Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CCDC73	493860	broad.mit.edu	37	11	32657319	32657319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:32657319C>T	ENST00000335185.5	-	14	1151	c.1108G>A	c.(1108-1110)Gaa>Aaa	p.E370K	CCDC73_ENST00000534415.1_5'UTR	NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	370										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					ATATGAGTTTCTTTAAGGGAT	0.254000													11	27					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48733332	48733332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48733332G>A	ENST00000285238.8	+	2	265	c.185G>A	c.(184-186)gGc>gAc	p.G62D	ABCC3_ENST00000427699.1_Missense_Mutation_p.G62D	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	62					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CATTGTCGTGGCTACATCATC	0.582000													15	48					0	0	1	0	0
MYEOV	26579	broad.mit.edu	37	11	69063588	69063588	+	Missense_Mutation	SNP	C	C	T	rs138762742	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:69063588C>T	ENST00000535407.1	+	2	1140	c.497C>T	c.(496-498)tCg>tTg	p.S166L	MYEOV_ENST00000308946.3_Missense_Mutation_p.S224L|MYEOV_ENST00000441339.2_Missense_Mutation_p.S224L			Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	224										endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|urinary_tract(1)	24	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		CTGGCAGAATCGAGCTGCCCT	0.637000													31	47					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755960	140755960	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140755960C>T	ENST00000517434.1	+	1	2310	c.2310C>T	c.(2308-2310)ttC>ttT	p.F770F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTGATTTTCCCCCAGCCCA	0.517000													32	120					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48703660	48703660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48703660C>T	ENST00000352832.5	+	34	6673	c.6301C>T	c.(6301-6303)Ctc>Ttc	p.L2101F	CACNA1G_ENST00000514717.1_Missense_Mutation_p.L2078F|CACNA1G_ENST00000515765.1_Missense_Mutation_p.L2172F|CACNA1G_ENST00000510366.1_Missense_Mutation_p.L2083F|CACNA1G_ENST00000512389.1_Missense_Mutation_p.L2124F|CACNA1G_ENST00000513964.1_Missense_Mutation_p.L2090F|CACNA1G_ENST00000513689.2_Missense_Mutation_p.L2138F|CACNA1G_ENST00000507609.1_Missense_Mutation_p.L2128F|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000507336.1_Missense_Mutation_p.L2217F|CACNA1G_ENST00000507510.2_Missense_Mutation_p.L2183F|CACNA1G_ENST00000442258.2_Missense_Mutation_p.L2094F|CACNA1G_ENST00000514181.1_Missense_Mutation_p.L2110F|CACNA1G_ENST00000429973.2_Missense_Mutation_p.L2117F|CACNA1G_ENST00000514079.1_Missense_Mutation_p.L2142F|CACNA1G_ENST00000515165.1_Missense_Mutation_p.L2135F|CACNA1G_ENST00000510115.1_Missense_Mutation_p.L2149F|CACNA1G_ENST00000503485.1_Missense_Mutation_p.L2101F|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000502264.1_Missense_Mutation_p.L2157F|CACNA1G_ENST00000359106.5_Missense_Mutation_p.L2228F|CACNA1G_ENST00000354983.4_Missense_Mutation_p.L2194F|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000515411.1_Missense_Mutation_p.L2165F|CACNA1G_ENST00000360761.4_Missense_Mutation_p.L2112F	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	2228					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TTCAGGAGACCTCCTGCCCCC	0.662000											OREG0024569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	50					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61562318	61562318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61562318G>A	ENST00000577647.1	+	1	135	c.90G>A	c.(88-90)gaG>gaA	p.E30E	ACE_ENST00000290863.6_Silent_p.E30E|ACE_ENST00000413513.3_Silent_p.E30E|ACE_ENST00000290866.4_Intron|ACE_ENST00000490216.2_Silent_p.E30E|ACE_ENST00000428043.1_Intron|ACE_ENST00000421982.2_5'UTR			P12821	ACE_HUMAN	angiotensin I converting enzyme	0	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CCAGCCAGGAGGCATCCCAAC	0.652000													6	12					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112720813	112720813	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:112720813G>A	ENST00000408903.3	-	2	682	c.267C>T	c.(265-267)tcC>tcT	p.S89S	CTD-2201G3.1_ENST00000416046.2_RNA	NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	0					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		AATCCTGAAAGGAAATCTTCC	0.448000													45	104					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247737658	247737658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247737658G>A	ENST00000366491.2	+	7	819	c.322G>A	c.(322-324)Gat>Aat	p.D108N	RP11-978I15.10_ENST00000446347.1_RNA|GCSAML_ENST00000527084.1_Missense_Mutation_p.D96N|GCSAML_ENST00000463359.1_Missense_Mutation_p.D96N|GCSAML_ENST00000366488.4_Missense_Mutation_p.D128N|RP11-978I15.10_ENST00000435333.1_RNA|GCSAML_ENST00000366489.1_Missense_Mutation_p.D108N|GCSAML_ENST00000527541.1_Missense_Mutation_p.D96N|GCSAML_ENST00000536561.1_Missense_Mutation_p.D108N					germinal center-associated, signaling and motility-like																		CCATGAGCATGATTATGAAGT	0.438000													32	72					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193201771	193201771	+	Silent	SNP	G	G	A	rs111773905	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:193201771G>A	ENST00000342695.4	-	8	1084	c.762C>T	c.(760-762)ctC>ctT	p.L254L	ATP13A4_ENST00000392443.3_Silent_p.L254L|ATP13A4_ENST00000295548.3_Silent_p.L254L	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	254					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GTGACTCGACGAGATGGTGGA	0.348000													48	63					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97852431	97852431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:97852431G>A	ENST00000447648.2	-	21	3098	c.2799C>T	c.(2797-2799)gcC>gcT	p.A933A	TECPR1_ENST00000379795.3_Silent_p.A935A|TECPR1_ENST00000479975.1_5'UTR			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	933						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CGTCCCTGAGGGCGATGGGGG	0.667000													3	8					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6925289	6925289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6925289C>T	ENST00000011653.4	+	6	933	c.675C>T	c.(673-675)ctC>ctT	p.L225L	CD4_ENST00000541982.1_3'UTR|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	225	Ig-like C2-type 2.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				CCTTCCCACTCGCCTTTACAG	0.562000													39	71					0	0	1	0	0
SRRM3	222183	broad.mit.edu	37	7	75894696	75894696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:75894696C>T	ENST00000388802.4	+	10	949	c.740C>T	c.(739-741)tCc>tTc	p.S247F	SRRM3_ENST00000326382.8_Missense_Mutation_p.S247F					serine/arginine repetitive matrix 3									p.S247Y(1)		NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)	8						CACACAGAGTCCCCAGGCCGG	0.642000													22	45					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21225528	21225528	+	Missense_Mutation	SNP	C	C	T	rs61743313	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21225528C>T	ENST00000233242.1	-	29	12893	c.12766G>A	c.(12766-12768)Gag>Aag	p.E4256K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4256					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCCTTAACTCGAAAGGAAGT	0.378000													38	106					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71740883	71740883	+	Missense_Mutation	SNP	G	G	A	rs146975565		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:71740883G>A	ENST00000269500.5	-	10	1453	c.1118C>T	c.(1117-1119)tCg>tTg	p.S373L	FBXO15_ENST00000580806.1_5'UTR|FBXO15_ENST00000419743.2_Missense_Mutation_p.S449L	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	373										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		TGTGGCAGGCGATCTCAGGCA	0.502000													55	197					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40815211	40815211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40815211G>A	ENST00000396617.3	-	12	1821	c.1231C>T	c.(1231-1233)Cca>Tca	p.P411S	MKL1_ENST00000407029.1_Missense_Mutation_p.P411S|MKL1_ENST00000355630.3_Missense_Mutation_p.P411S|MKL1_ENST00000402042.1_Missense_Mutation_p.P361S			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	411					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						CGGGCCGCTGGGAAGGCTACC	0.677000			T	RBM15	acute megakaryocytic leukemia								3	9					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62995971	62995971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62995971C>T	ENST00000306494.6	-	2	467	c.468G>A	c.(466-468)atG>atA	p.M156I	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A25_ENST00000403374.2_5'UTR	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	156					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CTCCCACCATCATTCCAGCCA	0.408000													17	84					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77799640	77799640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:77799640G>A	ENST00000407578.2	-	19	3053	c.2787C>T	c.(2785-2787)taC>taT	p.Y929Y	MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Silent_p.Y891Y|MYCBP2_ENST00000544440.2_Silent_p.Y891Y	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	891					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGCCTGGAGGGTATGTTGTGA	0.443000													38	84					0	0	1	0	0
MIR371B	100616185	broad.mit.edu	37	19	54290995	54290995	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54290995C>T	ENST00000595160.1	-	0	301				MIR371A_ENST00000362161.1_RNA	NR_029864.1|NR_029865.1|NR_039909.1																						TTGAGTGTTACCGCTTGAGAA	0.572000													10	27					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7173259	7173259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7173259C>T	ENST00000406697.1	+	10	1484	c.856C>T	c.(856-858)Cgc>Tgc	p.R286C	C1S_ENST00000328916.3_Missense_Mutation_p.R286C|C1S_ENST00000402681.3_Missense_Mutation_p.R119C|C1S_ENST00000360817.5_Missense_Mutation_p.R286C			P09871	C1S_HUMAN	complement component 1, s subcomponent	286	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	CTGGAAACTTCGCTATCATGG	0.433000													22	65					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57666645	57666645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57666645C>T	ENST00000554048.2	-	5	533	c.534G>A	c.(532-534)gaG>gaA	p.E178E		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	178						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CTTGCAGTCCCTCAGGAATCT	0.498000													5	81					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561313	9561313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9561313C>T	ENST00000378429.3	-	5	1015	c.469G>A	c.(469-471)Gat>Aat	p.D157N	PAK7_ENST00000378423.1_Missense_Mutation_p.D157N|PAK7_ENST00000353224.5_Missense_Mutation_p.D157N	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	157	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TAATACGGATCCAGATCATCT	0.483000													60	166					0	0	1	0	0
NR6A1	2649	broad.mit.edu	37	9	127302413	127302413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127302413C>T	ENST00000487099.2	-	5	652	c.495G>A	c.(493-495)gaG>gaA	p.E165E	NR6A1_ENST00000373584.3_Silent_p.E161E|NR6A1_ENST00000416460.2_Silent_p.E161E|NR6A1_ENST00000344523.4_Silent_p.E165E	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	165					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						AGTGATTGGCCTCTTCCTCAA	0.512000													27	140					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113285537	113285537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113285537G>A	ENST00000389385.4	+	5	617	c.120G>A	c.(118-120)caG>caA	p.Q40Q	RPH3A_ENST00000420983.2_Silent_p.Q40Q|RPH3A_ENST00000415485.3_Silent_p.Q40Q|RPH3A_ENST00000551052.1_Silent_p.Q36Q|RPH3A_ENST00000543106.2_Silent_p.Q40Q|RPH3A_ENST00000447659.2_Intron|RPH3A_ENST00000548866.1_Intron	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	40					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CCGGTGGTCAGCCTGACAGGC	0.532000													39	78					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30381660	30381660	+	Missense_Mutation	SNP	G	G	A	rs61754553	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30381660G>A	ENST00000340513.4	+	15	2155	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K	TPX2_ENST00000300403.6_Missense_Mutation_p.E507K			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	507					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GGAAGAGGACGAACCGGTAGT	0.433000													87	214					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31918627	31918627	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31918627G>A	ENST00000396184.3	-	5	611	c.407C>T	c.(406-408)gCt>gTt	p.A136V	PDE1C_ENST00000396191.1_Missense_Mutation_p.A136V|PDE1C_ENST00000321453.7_Missense_Mutation_p.A136V|PDE1C_ENST00000396193.1_Missense_Mutation_p.A196V|PDE1C_ENST00000396182.2_Missense_Mutation_p.A136V	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	136					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			AAATATCCCAGCCTGCACTGC	0.507000													25	134					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774626	121774626	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121774626G>A	ENST00000264808.3	-	3	487	c.247C>T	c.(247-249)Cgc>Tgc	p.R83C	PRDM5_ENST00000428209.2_Missense_Mutation_p.R83C|PRDM5_ENST00000515109.1_Missense_Mutation_p.R83C|PRDM5_ENST00000394435.2_Missense_Mutation_p.R83C	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	83	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGAACGAAGCGAAGCCAGTTG	0.468000													36	426					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49700992	49700992	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49700992G>A	ENST00000433368.2	-	6	575	c.506C>T	c.(505-507)tCt>tTt	p.S169F	CRISP3_ENST00000393666.1_Missense_Mutation_p.S146F|CRISP3_ENST00000423399.2_Missense_Mutation_p.S56F|CRISP3_ENST00000371159.4_Missense_Mutation_p.S177F|CRISP3_ENST00000263045.4_Missense_Mutation_p.S159F	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	146					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GAGGTATGAAGAGTACCAAAC	0.328000													61	129					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77677851	77677851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77677851G>A	ENST00000296043.6	+	8	5912	c.4959G>A	c.(4957-4959)aaG>aaA	p.K1653K		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1653					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GTTTAGAAAAGAAAGTCAGTC	0.493000													22	78					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	122018775	122018775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122018775G>A	ENST00000377071.4	-	1	114	c.42C>T	c.(40-42)ccC>ccT	p.P14P	KDM2B_ENST00000536437.1_5'UTR|RP13-941N14.1_ENST00000541574.1_lincRNA|KDM2B_ENST00000538046.2_Silent_p.P14P	NM_032590.4	NP_115979.3	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	14					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						TTTTTCGTGGGGGGTGATCCT	0.483000													38	135					0	0	1	0	0
NR0B2	8431	broad.mit.edu	37	1	27238395	27238395	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27238395G>A	ENST00000254227.3	-	2	740	c.715C>T	c.(715-717)Cct>Tct	p.P239S		NM_021969.2	NP_068804.1	Q15466	NR0B2_HUMAN	nuclear receptor subfamily 0, group B, member 2	239					cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity			NS(1)|large_intestine(1)|lung(3)	5		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		CCAATGATAGGGCGAAAGAAG	0.612000													30	116					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608361	4608361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4608361G>A	ENST00000312614.4	+	1	341	c.319G>A	c.(319-321)Gtg>Atg	p.V107M		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCCTCCTCGGTGGTACCCAA	0.488000													30	269					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179430142	179430142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179430142C>T	ENST00000589042.1	-	326	80941	c.80717G>A	c.(80716-80718)cGa>cAa	p.R26906Q	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R24338Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R25265Q|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R18033Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R17966Q|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R17841Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25265							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGTCTTGGTCGGCCTATAAC	0.383000													27	80					0	0	1	0	0
FABP12	646486	broad.mit.edu	37	8	82441730	82441730	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:82441730G>A	ENST00000360464.4	-	2	251	c.189C>T	c.(187-189)atC>atT	p.I63I	RP11-257P3.3_ENST00000523380.1_RNA	NM_001105281.1	NP_001098751.1	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	63							lipid binding|transporter activity			large_intestine(1)|lung(3)	4						GCTTAAAGGAGATCTCATTAT	0.428000													45	97					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40944474	40944474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40944474G>A	ENST00000373198.3	-	12	2263	c.2028C>T	c.(2026-2028)acC>acT	p.T676T	PTPRT_ENST00000373187.1_Silent_p.T676T|PTPRT_ENST00000373193.3_Silent_p.T676T|PTPRT_ENST00000373201.1_Silent_p.T676T|PTPRT_ENST00000373184.1_Silent_p.T676T|PTPRT_ENST00000356100.2_Silent_p.T676T|PTPRT_ENST00000373190.1_Silent_p.T676T	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	676	Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TAAATGGCTGGGTGACAGGCA	0.517000													52	90					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48414342	48414342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48414342G>A	ENST00000249598.1	-	2	685	c.526C>T	c.(526-528)Ctg>Ttg	p.L176L		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	176					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						GTTCCATCCAGAACATCATAA	0.522000													16	43					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875795	247875795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247875795C>T	ENST00000302084.2	-	1	310	c.263G>A	c.(262-264)aGa>aAa	p.R88K	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGTCTGACTTCTCCCCAGTAG	0.478000													33	79					0	0	1	0	0
FAM188A	80013	broad.mit.edu	37	10	15828640	15828640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15828640G>A	ENST00000378036.1	-	4	1327	c.151C>T	c.(151-153)Ctc>Ttc	p.L51F	FAM188A_ENST00000477891.1_5'UTR|FAM188A_ENST00000277632.3_Missense_Mutation_p.L346F			Q9H8M7	F188A_HUMAN	family with sequence similarity 188, member A	346					apoptosis	nucleus	calcium ion binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	22						TTCTTCATGAGATTTATACTA	0.328000													19	103					0	0	1	0	0
ALG13	79868	broad.mit.edu	37	X	110988108	110988108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:110988108C>T	ENST00000394780.3	+	24	2920	c.2908C>T	c.(2908-2910)Cca>Tca	p.P970S	ALG13_ENST00000251943.4_Intron|ALG13_ENST00000470971.1_3'UTR	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	970	Pro-rich.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						TTCCTGTGATCCAAGCGGCAG	0.463000													6	8					0	0	1	0	0
OR5K3	403277	broad.mit.edu	37	3	98110023	98110023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98110023C>T	ENST00000383695.1	+	1	514	c.514C>T	c.(514-516)Cat>Tat	p.H172Y	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005516.1	NP_001005516.1	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K, member 3	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|prostate(1)|skin(1)|urinary_tract(1)	27						CTGTGGGTCTCATCAAATCAA	0.388000													38	103					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70502256	70502256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70502256C>T	ENST00000310961.5	+	21	2556	c.2138C>T	c.(2137-2139)tCc>tTc	p.S713F	LRRC7_ENST00000035383.5_Missense_Mutation_p.S708F|LRRC7_ENST00000415775.2_Intron			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	708						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AAAGTGGGGTCCTTGCAGACA	0.448000													43	102					0	0	1	0	0
ENPP4	22875	broad.mit.edu	37	6	46107906	46107906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46107906G>A	ENST00000321037.4	+	2	816	c.586G>A	c.(586-588)Gga>Aga	p.G196R		NM_014936.4	NP_055751.1	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)	196						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	18						CCACAAATACGGACCTGAAGA	0.383000													43	89					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150948210	150948210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150948210G>A	ENST00000261800.5	-	1	295	c.283C>T	c.(283-285)Cta>Tta	p.L95L		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	95	Cadherin 1.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTATTCTTAGGAAGCAGAAG	0.512000													41	322					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36348748	36348748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36348748G>A	ENST00000360631.3	-	17	2358	c.2147C>T	c.(2146-2148)cCc>cTc	p.P716L	DCLK1_ENST00000379893.1_Missense_Mutation_p.P409L|DCLK1_ENST00000255448.4_3'UTR			O15075	DCLK1_HUMAN	doublecortin-like kinase 1	716					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GTTGAGTTCGGGAGGAGCTGG	0.552000													3	5					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813687	123813687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123813687G>A	ENST00000321252.2	-	1	893	c.859C>T	c.(859-861)Cca>Tca	p.P287S		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AAGATGAATGGGTTCAAGAGG	0.522000													26	227					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088532	94088532	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94088532G>A	ENST00000553484.1	+	31	5173	c.5019G>A	c.(5017-5019)acG>acA	p.T1673T	UNC79_ENST00000555664.1_Silent_p.T1651T|UNC79_ENST00000256339.4_Silent_p.T1474T|UNC79_ENST00000393151.2_Silent_p.T1651T			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1651						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AAGAGGAGACGATGAACCAAG	0.552000													35	91					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16026284	16026284	+	Missense_Mutation	SNP	C	C	T	rs13306549		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16026284C>T	ENST00000350896.3	-	4	510	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	MSR1_ENST00000381998.4_Missense_Mutation_p.E105K|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000262101.5_Missense_Mutation_p.E105K|MSR1_ENST00000445506.2_Missense_Mutation_p.E123K|MSR1_ENST00000355282.2_Missense_Mutation_p.E105K	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	105	Spacer (Probable).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTTCCTCTTCGCTGTCATTT	0.403000													99	94					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825276	4825276	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4825276G>A	ENST00000380382.1	-	1	571	c.572C>T	c.(571-573)tCt>tTt	p.S191F	MMP26_ENST00000477339.1_Intron|OR52R1_ENST00000356069.2_Missense_Mutation_p.S112F|MMP26_ENST00000380390.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGACTCCACAGAAGAAAAGGC	0.522000													27	98					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149499582	149499582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149499582G>A	ENST00000261799.4	-	19	3160	c.2691C>T	c.(2689-2691)ttC>ttT	p.F897F		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	897	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TACCCAAGGTGAAGATCTCCC	0.582000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								12	75					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1246031	1246031	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1246031C>T	ENST00000324642.3	+	12	1848	c.1725C>T	c.(1723-1725)tcC>tcT	p.S575S		NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	575					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGCTGCTGTCCTTGCTGCCCG	0.716000													13	22					0	0	1	0	0
RNF141	50862	broad.mit.edu	37	11	10555624	10555624	+	Nonsense_Mutation	SNP	G	G	A	rs144898917		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10555624G>A	ENST00000265981.2	-	2	224	c.82C>T	c.(82-84)Cga>Tga	p.R28*	RNF141_ENST00000528665.1_Nonsense_Mutation_p.R28*	NM_016422.3	NP_057506.2	Q8WVD5	RN141_HUMAN	ring finger protein 141	28							zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|urinary_tract(1)	9				all cancers(16;4.63e-08)|Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.064)		CCACTCTCTCGAACCAACGTA	0.383000													58	119					0	0	1	0	0
DGCR14	8220	broad.mit.edu	37	22	19125809	19125809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19125809G>A	ENST00000252137.6	-	7	887	c.844C>T	c.(844-846)Ccc>Tcc	p.P282S		NM_022719.2	NP_073210.1	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region gene 14	282					nervous system development	catalytic step 2 spliceosome				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	16	Colorectal(54;0.0993)					TTGCCATCGGGGCCCACCTTG	0.627000													10	28					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473672	19473672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:19473672G>A	ENST00000507958.1	-	15	3026	c.2036C>T	c.(2035-2037)cCt>cTt	p.P679L	CDH18_ENST00000510297.1_5'UTR|CDH18_ENST00000382275.1_Missense_Mutation_p.P679L|CDH18_ENST00000274170.4_Missense_Mutation_p.P679L			Q13634	CAD18_HUMAN	cadherin 18, type 2	679					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGCAGCAGAAGGATTCCTCAA	0.507000													51	97					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74468459	74468459	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74468459C>A	ENST00000249842.3	+	2	1617	c.1260C>A	c.(1258-1260)ctC>ctA	p.L420L	ISLR_ENST00000395118.1_Silent_p.L420L|RP11-665J16.1_ENST00000561647.1_RNA	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	420					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						AAAGCCTCCTCCTCTTCTTCT	0.637000													34	31					9.17885e-22	9.23614e-22	1	1	0
TMEM180	79847	broad.mit.edu	37	10	104230740	104230740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104230740C>T	ENST00000238936.4	+	5	807	c.570C>T	c.(568-570)tcC>tcT	p.S190S	TMEM180_ENST00000369931.3_Intron|TMEM180_ENST00000366277.2_Intron	NM_024789.3	NP_079065.2	Q14CX5	TM180_HUMAN	transmembrane protein 180	190						integral to membrane				breast(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|skin(1)	13		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		AGGATTTCTCCTCCTTCCGCG	0.617000													48	114					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7682521	7682521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7682521G>A	ENST00000446248.2	+	18	3600	c.3499G>A	c.(3499-3501)Gaa>Aaa	p.E1167K	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.E1140K	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	1140	CKK.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CAAGGTGAACGAACCGCAGAA	0.597000													11	35					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1095344	1095344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1095344C>T	ENST00000441003.2	+	32	6191	c.6164C>T	c.(6163-6165)cCt>cTt	p.P2055L	MUC2_ENST00000361558.6_Missense_Mutation_p.P193L|MUC2_ENST00000333592.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4417						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GACTTTGATCCTCCCAGACAG	0.682000													8	27					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543331	182543331	+	Missense_Mutation	SNP	G	G	A	rs147793698	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182543331G>A	ENST00000295108.3	-	2	714	c.257C>T	c.(256-258)cCc>cTc	p.P86L	CERKL_ENST00000479558.1_Intron|NEUROD1_ENST00000496876.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	86					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CTTCTTTTTGGGGCCGCGTCT	0.562000													7	35					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164783108	164783108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164783108G>A	ENST00000264382.3	-	7	810	c.748C>T	c.(748-750)Cgt>Tgt	p.R250C		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	250	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.R250C(2)		NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AAATCATGACGAAATCTCTTA	0.343000										HNSCC(35;0.089)			27	47					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142486068	142486068	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142486068C>T	ENST00000430863.1	-	0	1705					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GGGTCCCCAGCCCTGGTGCGT	0.602000													5	18					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52601976	52601976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:52601976G>A	ENST00000395961.3	-	7	1156	c.990C>T	c.(988-990)tcC>tcT	p.S330S	BCAS1_ENST00000371435.2_Silent_p.S330S|BCAS1_ENST00000371440.3_Silent_p.S375S|BCAS1_ENST00000434986.2_Silent_p.S88S	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	330						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			GGGTCTCCTGGGATGTAAAGT	0.493000													75	173					0	0	1	0	0
RP11-50E11.3	0	broad.mit.edu	37	10	52389396	52389396	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52389396C>T	ENST00000443374.1	+	0	89																											CCCCAAGCTCCTCTATCAGAG	0.547000													25	53					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50962182	50962182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50962182C>T	ENST00000357701.5	+	22	2565	c.2514C>T	c.(2512-2514)ccC>ccT	p.P838P		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	838	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CAGAGCCACCCAAGATCCGGC	0.667000													3	17					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707821	50707821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50707821G>A	ENST00000330943.4	-	4	618	c.447C>T	c.(445-447)ttC>ttT	p.F149F	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	149	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						TCTCCTCAGCGAAGTTCCCAG	0.617000													7	41					0	0	1	0	0
RSAD1	55316	broad.mit.edu	37	17	48559733	48559733	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48559733C>T	ENST00000258955.2	+	4	841	c.756C>T	c.(754-756)ctC>ctT	p.L252L		NM_018346.1	NP_060816.1	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing 1	252					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			ACCCGGAGCTCGCAGCTGAGA	0.647000											OREG0024567	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	79					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133894781	133894781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133894781C>T	ENST00000220616.4	+	7	853	c.813C>T	c.(811-813)ttC>ttT	p.F271F	TG_ENST00000377869.1_Silent_p.F271F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	271	Thyroglobulin type-1 3.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTTCCACCTTCACTGAAACCA	0.458000													21	228					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120984322	120984322	+	Missense_Mutation	SNP	G	G	A	rs150098939	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120984322G>A	ENST00000392793.1	+	6	956	c.685G>A	c.(685-687)Gag>Aag	p.E229K	TECTA_ENST00000264037.2_Missense_Mutation_p.E229K			O75443	TECTA_HUMAN	tectorin alpha	229	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AAGAACCCCCGAGATCGTGAA	0.478000													10	69					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51173447	51173447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51173447C>T	ENST00000440970.1	-	2	2826	c.2395G>A	c.(2395-2397)Gat>Aat	p.D799N	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.D896N	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	896					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GTCAGGACATCCCCCTCGATG	0.537000													17	53					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8530212	8530212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8530212C>T	ENST00000348943.3	+	6	675	c.443C>T	c.(442-444)cCt>cTt	p.P148L	HNRNPM_ENST00000325495.4_Missense_Mutation_p.P148L	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	148	RRM 1.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						TTTTAGGATCCTGATGGTGAA	0.463000													17	176					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765443	18765443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18765443C>T	ENST00000304081.4	-	5	902	c.802G>A	c.(802-804)Gag>Aag	p.E268K	NT5C1B_ENST00000359846.2_Missense_Mutation_p.E328K|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.E328K|NT5C1B_ENST00000600945.1_Missense_Mutation_p.E328K	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CCCTCTTGCTCGTAGATTTTC	0.552000													52	149					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48719832	48719832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48719832G>A	ENST00000316623.5	-	58	7591	c.7136C>T	c.(7135-7137)cCt>cTt	p.P2379L		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2379	TB 9.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCCCTGGAAAGGGCAGATCTC	0.527000													8	79					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29787322	29787322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29787322G>A	ENST00000269202.6	+	8	702	c.655G>A	c.(655-657)Gga>Aga	p.G219R	MEP1B_ENST00000581447.1_Missense_Mutation_p.G219R	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	219	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						ATTCCAAAATGGAACAGAGCC	0.393000													9	23					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122808458	122808458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122808458C>T	ENST00000194130.2	-	6	669	c.630G>A	c.(628-630)ggG>ggA	p.G210G	SLC13A1_ENST00000539873.1_Silent_p.G146G	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	210						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TTGAAATTTTCCCTGTATCAT	0.254000													16	78					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119033623	119033623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119033623G>A	ENST00000328252.3	+	9	3250	c.2881G>A	c.(2881-2883)Gac>Aac	p.D961N	PAPPA_ENST00000534838.1_5'UTR	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	961					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TGAACAATGCGACGACATGAA	0.448000													48	122					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40193564	40193564	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:40193564C>T	ENST00000360214.3	+	10	1590	c.1130C>T	c.(1129-1131)tCc>tTc	p.S377F	ETS2_ENST00000360938.3_Missense_Mutation_p.S377F	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	377					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TCAGACAAATCCTGCCAGTCA	0.547000													62	110					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89256747	89256747	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89256747C>T	ENST00000289746.2	+	8	1140	c.1075C>T	c.(1075-1077)Cag>Tag	p.Q359*		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	359	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		TGAGCGGGGCCAGGCCAAGGT	0.647000													9	20					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6007673	6007673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6007673C>T	ENST00000332249.4	-	1	542	c.488G>A	c.(487-489)gGa>gAa	p.G163E		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACCACCATTCCGATGCACCC	0.512000													6	85					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52579321	52579321	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52579321G>A	ENST00000313234.5	-	2	448	c.351C>T	c.(349-351)ttC>ttT	p.F117F	KRT80_ENST00000394815.2_Silent_p.F117F	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	117	Coil 1A.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		GGCCCTGCAGGAAGCTCCAGC	0.637000													7	43					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161123349	161123349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161123349G>A	ENST00000308192.9	+	1	76	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	PLG_ENST00000366924.2_Missense_Mutation_p.E5K|PLG_ENST00000462918.1_3'UTR	NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	5					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGAACATAAGGAAGTGGTTCT	0.368000													43	65					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39504228	39504228	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:39504228G>A	ENST00000518318.2	+	10	1953	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	POU6F2_ENST00000403058.1_Silent_p.E673E|POU6F2_ENST00000559001.1_Silent_p.E618E			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	673					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						AACAGCACGAGCCGGCCACGG	0.453000													8	10					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350174	51350174	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51350174G>A	ENST00000327536.5	-	3	882	c.783C>T	c.(781-783)ttC>ttT	p.F261F	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	261										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		GGGTGGAGAGGAACTCCACAT	0.517000													26	61					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16910720	16910720	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16910720G>A	ENST00000524140.2	+	17	3901	c.3483G>A	c.(3481-3483)ggG>ggA	p.G1161G	NWD1_ENST00000523826.1_Silent_p.G955G|NWD1_ENST00000379808.3_Silent_p.G1161G|NWD1_ENST00000552788.1_Silent_p.G1161G|NWD1_ENST00000339803.6_Silent_p.G1026G|NWD1_ENST00000549814.1_Intron	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1161							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAGAACAGGGGACCCTTCTGG	0.577000													20	46					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48556366	48556366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48556366C>T	ENST00000435803.1	+	52	13710	c.13686C>T	c.(13684-13686)tcC>tcT	p.S4562S	ABCA13_ENST00000544596.1_Silent_p.S292S	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4562					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GAATCTTTTCCAGTTCGGACG	0.388000													59	173					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1996226	1996226	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1996226C>T	ENST00000382722.5	-	7	1153	c.791G>A	c.(790-792)tGg>tAg	p.W264*	CACNA2D4_ENST00000585708.1_Nonsense_Mutation_p.W200*|CACNA2D4_ENST00000587995.1_Nonsense_Mutation_p.W264*|CACNA2D4_ENST00000586184.1_Nonsense_Mutation_p.W264*|CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000588077.1_Nonsense_Mutation_p.W200*	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	264						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity	p.W264*(1)		endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		ATCAGGTGTCCATTTTATACC	0.517000													3	11					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74659801	74659801	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74659801G>A	ENST00000268053.6	-	1	280	c.126C>T	c.(124-126)acC>acT	p.T42T	CYP11A1_ENST00000467407.1_5'UTR|CYP11A1_ENST00000541301.1_Silent_p.T42T	NM_000781.2	NP_000772.2	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	42					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GAGGACTGCGGGTGGAGATGC	0.622000													52	57					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117876	20117876	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20117876G>A	ENST00000397165.2	-	4	595	c.435C>T	c.(433-435)ttC>ttT	p.F145F	ZNF682_ENST00000595736.1_Silent_p.F69F|ZNF682_ENST00000597972.1_Silent_p.F151F|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000397162.1_Silent_p.F113F|ZNF682_ENST00000358523.5_Silent_p.F113F	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TATTATATGGGAAAATTTTGC	0.308000													20	44					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12384536	12384536	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12384536G>A	ENST00000356109.5	-	5	796	c.678C>T	c.(676-678)ttC>ttT	p.F226F	ZNF44_ENST00000355684.5_Silent_p.F178F	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		CAGGAGAACTGAAGGTTTTTC	0.413000													22	80					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47293917	47293917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47293917G>A	ENST00000225941.1	+	2	640	c.142G>A	c.(142-144)Gag>Aag	p.E48K	ABI3_ENST00000419580.2_Missense_Mutation_p.E48K	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	48					cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			GAAGGCGCTGGAGGAGACCAT	0.647000										HNSCC(55;0.14)			7	19					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328076	80328076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:80328076C>T	ENST00000358842.3	-	1	1296	c.1279G>A	c.(1279-1281)Gga>Aga	p.G427R		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	427					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						TTGGTCATTCCTCCATCTACC	0.418000													17	127					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117825450	117825450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117825450C>T	ENST00000350763.4	-	13	4190	c.3779G>A	c.(3778-3780)gGa>gAa	p.G1260E	TNC_ENST00000535648.1_Intron|TNC_ENST00000542877.1_Intron|TNC_ENST00000423613.2_Missense_Mutation_p.G1260E|TNC_ENST00000346706.3_Intron|TNC_ENST00000537320.1_Intron|TNC_ENST00000341037.4_Intron|TNC_ENST00000345230.3_Intron|TNC_ENST00000340094.3_Intron	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1260	Fibronectin type-III 8.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TGTGAGGTTTCCCATATCTGG	0.493000													14	33					0	0	1	0	0
DEAF1	10522	broad.mit.edu	37	11	688045	688045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:688045G>A	ENST00000382409.3	-	4	1014	c.530C>T	c.(529-531)cCt>cTt	p.P177L	DEAF1_ENST00000338675.6_Missense_Mutation_p.P177L	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	177					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		AGGGGTTGGAGGAGACTGAGG	0.572000													18	38					0	0	1	0	0
GAS2	2620	broad.mit.edu	37	11	22759280	22759280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:22759280C>T	ENST00000454584.2	+	5	744	c.439C>T	c.(439-441)Ctc>Ttc	p.L147F	GAS2_ENST00000433790.1_Missense_Mutation_p.L147F|GAS2_ENST00000278187.3_Missense_Mutation_p.L147F	NM_001143830.1	NP_001137302.1	O43903	GAS2_HUMAN	growth arrest-specific 2	147	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(4)|stomach(1)	24						AGAAGTGTGTCTCTGTCTGCT	0.488000													37	82					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89968486	89968486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89968486G>A	ENST00000405460.2	+	22	4972	c.4876G>A	c.(4876-4878)Gac>Aac	p.D1626N	GPR98_ENST00000450321.2_3'UTR	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1626	Calx-beta 11.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCTTGTTGATGACTTTGCTAA	0.403000													38	79					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30962216	30962216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30962216C>T	ENST00000311813.4	+	3	642	c.587C>T	c.(586-588)tCc>tTc	p.S196F	AQP1_ENST00000434909.2_Missense_Mutation_p.S256F|AQP1_ENST00000441328.2_Missense_Mutation_p.S113F|AQP1_ENST00000409899.1_Missense_Mutation_p.S81F|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Missense_Mutation_p.S145F|AQP1_ENST00000509504.1_Missense_Mutation_p.S373F	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				CCTGCTCGGTCCTTTGGCTCC	0.567000													97	263					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546350	11546350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11546350G>A	ENST00000389362.4	-	3	697	c.662C>T	c.(661-663)cCa>cTa	p.P221L	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGTCCTTGTGGCTTTCCTGG	0.612000													39	314					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34061368	34061368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34061368C>T	ENST00000397527.1	+	13	2099	c.1379C>T	c.(1378-1380)tCt>tTt	p.S460F	CEP250_ENST00000342580.4_Missense_Mutation_p.S460F	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	460					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAGGTGGACTCTCTCAGCAAG	0.597000													5	17					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10550730	10550730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10550730C>T	ENST00000583535.1	-	9	836	c.749G>A	c.(748-750)cGa>cAa	p.R250Q	MYH3_ENST00000226209.7_Missense_Mutation_p.R250Q	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	250	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.R250Q(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						AAAATGGATTCGGATGAACTT	0.483000													23	32					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87241866	87241866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87241866C>T	ENST00000297524.3	-	1	744	c.641G>A	c.(640-642)gGa>gAa	p.G214E	SLC7A13_ENST00000419776.2_Missense_Mutation_p.G214E|SLC7A13_ENST00000520624.1_Intron	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	214						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						TGCAAAATATCCTTGGAAGAT	0.363000													33	109					0	0	1	0	0
OR6C75	390323	broad.mit.edu	37	12	55759599	55759599	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55759599C>G	ENST00000343399.3	+	1	705	c.705C>G	c.(703-705)gcC>gcG	p.A235A		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	235			A -> D (in dbSNP:rs7976416).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						GGAAAAAAGCCTTTTCCACTT	0.393000													27	52					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47663777	47663777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47663777C>T	ENST00000273857.4	-	12	1685	c.1686G>A	c.(1684-1686)gaG>gaA	p.E562E	CORIN_ENST00000504584.1_Silent_p.E525E|CORIN_ENST00000502252.1_Silent_p.E495E|CORIN_ENST00000505909.1_Silent_p.E525E|CORIN_ENST00000508498.1_Silent_p.E423E	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	562	FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						CTGAATTTTCCTCTGGAAATT	0.413000													25	72					0	0	1	0	0
OPALIN	93377	broad.mit.edu	37	10	98105809	98105809	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98105809C>T	ENST00000419479.1	-	7	792	c.285G>A	c.(283-285)gtG>gtA	p.V95V	OPALIN_ENST00000536387.1_Silent_p.V95V|OPALIN_ENST00000371172.3_Silent_p.V105V|OPALIN_ENST00000393871.1_Silent_p.V82V|OPALIN_ENST00000393870.2_Silent_p.V94V	NM_001040103.1	NP_001035192.1	Q96PE5	OPALI_HUMAN	oligodendrocytic myelin paranodal and inner loop protein	105						Golgi apparatus|integral to membrane|plasma membrane				breast(1)|large_intestine(1)|lung(5)|prostate(2)	9						CTACAGTCTTCACATATATGT	0.453000													56	150					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298516	107298516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107298516G>A	ENST00000374781.2	-	1	621	c.579C>T	c.(577-579)gcC>gcT	p.A193A		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						GCAGTCTCATGGCAAGTAATG	0.433000													53	114					0	0	1	0	0
COG2	22796	broad.mit.edu	37	1	230798890	230798890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230798890C>T	ENST00000534989.1	+	4	462	c.127C>T	c.(127-129)Ctt>Ttt	p.L43F	COG2_ENST00000366668.3_Missense_Mutation_p.L102F|COG2_ENST00000366669.4_Missense_Mutation_p.L102F|COG2_ENST00000535166.1_5'UTR|COG2_ENST00000494371.1_3'UTR			Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	102					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TTTAAAGAGCCTTAGATCGTC	0.318000													9	64					0	0	1	0	0
SPARCL1	8404	broad.mit.edu	37	4	88415537	88415537	+	Missense_Mutation	SNP	C	C	T	rs140130359		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88415537C>T	ENST00000418378.1	-	5	986	c.415G>A	c.(415-417)Gat>Aat	p.D139N	SPARCL1_ENST00000503414.1_Missense_Mutation_p.D14N|SPARCL1_ENST00000282470.6_Missense_Mutation_p.D139N	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	139					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		GCCAAAAAATCAGTGTTCTCT	0.378000													51	119					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51189562	51189562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51189562C>T	ENST00000293441.1	-	20	2527	c.2509G>A	c.(2509-2511)Gaa>Aaa	p.E837K	SHANK1_ENST00000359082.3_Missense_Mutation_p.E828K|SHANK1_ENST00000391813.1_Missense_Mutation_p.E224K|SHANK1_ENST00000391814.1_Missense_Mutation_p.E845K	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	837					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CCAGGGCTTTCGCTTGCACTG	0.562000													26	57					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	601380	601380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:601380C>T	ENST00000219611.2	+	8	2508	c.2145C>T	c.(2143-2145)ccC>ccT	p.P715P	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		GCCTGCGCCCCCGGCATGCCT	0.677000													20	41					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914329	107914329	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107914329G>A	ENST00000280758.5	+	2	1729	c.1201G>A	c.(1201-1203)Gaa>Aaa	p.E401K	BTBD11_ENST00000420571.2_Missense_Mutation_p.E401K|BTBD11_ENST00000490090.2_Missense_Mutation_p.E401K	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	401						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CAAGCCAGGGGAACTGCCCAT	0.552000													16	126					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6078444	6078444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6078444G>A	ENST00000261405.5	-	45	7916	c.7662C>T	c.(7660-7662)gtC>gtT	p.V2554V		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2554					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GGCAGACAGGGACCTCCAGCT	0.617000													10	39					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141006949	141006949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:141006949C>T	ENST00000277549.5	+	40	5679	c.3110C>T	c.(3109-3111)cCc>cTc	p.P1037L	CACNA1B_ENST00000371357.1_Missense_Mutation_p.P1842L|CACNA1B_ENST00000371363.1_Missense_Mutation_p.P1841L|CACNA1B_ENST00000277551.2_Missense_Mutation_p.P1843L|CACNA1B_ENST00000371365.2_3'UTR|CACNA1B_ENST00000371355.4_Missense_Mutation_p.P1844L|CACNA1B_ENST00000371372.1_Missense_Mutation_p.P1843L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1843					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTGGTACCACCCCATAAGCGT	0.577000													15	28					0	0	1	0	0
ESM1	11082	broad.mit.edu	37	5	54277897	54277897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54277897C>T	ENST00000381405.4	-	2	524	c.379G>A	c.(379-381)Gga>Aga	p.G127R	ESM1_ENST00000598310.1_Intron|ESM1_ENST00000381403.4_Intron	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	127					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			AGGCATTTTCCCGTCCCCCTG	0.493000													49	109					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149883447	149883447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149883447G>A	ENST00000369146.3	-	3	1198	c.708C>T	c.(706-708)ctC>ctT	p.L236L	SV2A_ENST00000369145.1_Silent_p.L236L	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	236					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	AGAGCGAGATGAGCAGACACT	0.587000													15	51					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321852	78321852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78321852C>T	ENST00000582970.1	+	29	9860	c.9717C>T	c.(9715-9717)ccC>ccT	p.P3239P	RNF213_ENST00000508628.2_Silent_p.P3288P|RNF213_ENST00000336301.6_Silent_p.P1312P	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGCAGGGTCCCCGGGCCTTGA	0.617000													17	49					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81654595	81654595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81654595G>A	ENST00000558726.1	-	4	495	c.360C>T	c.(358-360)ttC>ttT	p.F120F	TMC3_ENST00000359440.5_Silent_p.F120F			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	120						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						CCCAGGGAATGAAGATGACCA	0.483000													12	19					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105405844	105405844	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105405844A>G	ENST00000333244.5	-	7	16063	c.15944T>C	c.(15943-15945)cTt>cCt	p.L5315P	AHNAK2_ENST00000557457.1_Missense_Mutation_p.L313P	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5315						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGTTTCTGGAAGCCTCATGCC	0.507000													19	31					0	0	1	0	0
PTCD2	79810	broad.mit.edu	37	5	71616244	71616244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71616244C>T	ENST00000380639.5	+	1	51	c.35C>T	c.(34-36)cCc>cTc	p.P12L	PTCD2_ENST00000543322.1_Missense_Mutation_p.P12L|PTCD2_ENST00000503868.1_Missense_Mutation_p.P12L|PTCD2_ENST00000536805.1_5'UTR	NM_024754.3	NP_079030.3	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	12										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(1)|skin(1)	11		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		GCATTTCGGCCCTCGAATCGA	0.622000													12	51					0	0	1	0	0
OR51F2	119694	broad.mit.edu	37	11	4842683	4842683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4842683C>T	ENST00000322110.5	+	1	133	c.68C>T	c.(67-69)cCt>cTt	p.P23L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTGCTGAGCCTCTGATCTTC	0.438000													115	272					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153661466	153661466	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153661466C>T	ENST00000368680.3	+	16	2927	c.2455C>T	c.(2455-2457)Cgc>Tgc	p.R819C		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	819					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CCTGCTGTCCCGCATGGAGCA	0.627000													38	156					0	0	1	0	0
PSTPIP2	9050	broad.mit.edu	37	18	43591154	43591154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43591154C>T	ENST00000409746.5	-	5	418	c.347G>A	c.(346-348)cGa>cAa	p.R116Q	PSTPIP2_ENST00000589328.1_Missense_Mutation_p.R116Q|PSTPIP2_ENST00000588801.1_5'UTR	NM_024430.3	NP_077748.3	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting protein 2	116						membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	17						AACCTTTTTTCGTTGTAGTTT	0.428000													16	198					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79290481	79290481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79290481C>T	ENST00000419573.3	-	20	3245	c.2971G>A	c.(2971-2973)Gag>Aag	p.E991K	RASGRF1_ENST00000558480.2_Missense_Mutation_p.E975K|RASGRF1_ENST00000394745.3_Missense_Mutation_p.E207K|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	993					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GTCAGGAGCTCCGGGTCGTGC	0.587000													29	150					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83221249	83221249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83221249C>T	ENST00000563800.1	-	8	2987	c.1262G>A	c.(1261-1263)cGa>cAa	p.R421Q	CPEB1_ENST00000398592.2_Missense_Mutation_p.R168Q|CPEB1_ENST00000261723.6_Missense_Mutation_p.R397Q|RP11-152F13.10_ENST00000562833.1_Missense_Mutation_p.E129K|CPEB1_ENST00000568757.1_Missense_Mutation_p.R319Q|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000562019.1_Missense_Mutation_p.R399Q|CPEB1_ENST00000398591.2_Missense_Mutation_p.R324Q|CPEB1_ENST00000568128.1_Missense_Mutation_p.R394Q|CPEB1_ENST00000450751.2_Missense_Mutation_p.R319Q|CPEB1_ENST00000423133.2_Missense_Mutation_p.R319Q|CPEB1_ENST00000564522.1_Missense_Mutation_p.R319Q			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	399	Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			GCGCATCCTTCGGCTGGACAT	0.502000													7	77					0	0	1	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186862233	186862233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186862233C>T	ENST00000367466.3	+	4	358	c.206C>T	c.(205-207)cCt>cTt	p.P69L	PLA2G4A_ENST00000442353.2_Missense_Mutation_p.P69L|PLA2G4A_ENST00000466600.1_3'UTR	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	69	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	GACATAAACCCTGTGTGGAAT	0.378000													68	217					0	0	1	0	0
HSF2BP	11077	broad.mit.edu	37	21	44949807	44949807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:44949807G>A	ENST00000291560.2	-	9	1163	c.832C>T	c.(832-834)Ctt>Ttt	p.L278F	HSF2BP_ENST00000542962.1_Missense_Mutation_p.L203F	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	278					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		GACTGGACAAGCCTCAGTACA	0.458000													24	49					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975912	20975912	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20975912C>T	ENST00000261383.3	-	53	9293	c.9294G>A	c.(9292-9294)gcG>gcA	p.A3098A	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3098	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.A3098A(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCAGTTTATTCGCCTTCTCCA	0.468000													43	107					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5457778	5457778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:5457778C>T	ENST00000296564.7	+	12	1247	c.1025C>T	c.(1024-1026)cCt>cTt	p.P342L		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	342	Pro-rich.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						CTTCCCCCTCCTCTTCTGTCA	0.463000													22	275					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064619	9064619	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9064619G>A	ENST00000397910.4	-	3	23030	c.22827C>T	c.(22825-22827)gcC>gcT	p.A7609A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7611	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGACAGAGGAGGCAGAAATCC	0.478000													22	65					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48248804	48248804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48248804G>A	ENST00000394747.1	-	8	1585	c.1236C>T	c.(1234-1236)ctC>ctT	p.L412L	ABCC11_ENST00000394748.1_Silent_p.L412L|ABCC11_ENST00000353782.5_Silent_p.L412L|ABCC11_ENST00000537808.1_Silent_p.L412L|ABCC11_ENST00000356608.2_Silent_p.L412L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	412	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TTGACGCTGTGAGTTTCAGCT	0.502000													18	41					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54153116	54153116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:54153116G>A	ENST00000404125.1	-	13	1693	c.1638C>T	c.(1636-1638)ttC>ttT	p.F546F	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	546					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ACTGTAAGACGAAATCCTCAA	0.363000													18	61					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38144728	38144728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38144728C>T	ENST00000379747.4	-	19	2375	c.2258G>A	c.(2257-2259)cGa>cAa	p.R753Q	POSTN_ENST00000379749.4_Missense_Mutation_p.R753Q|POSTN_ENST00000541481.1_Intron|POSTN_ENST00000541179.1_Missense_Mutation_p.R726Q|POSTN_ENST00000379743.4_Missense_Mutation_p.R726Q|POSTN_ENST00000379742.4_Missense_Mutation_p.R696Q|POSTN_ENST00000497145.1_5'UTR	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	753					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TGTAATGATTCGTTCTTCTCG	0.318000													17	88					0	0	1	0	0
DYX1C1	161582	broad.mit.edu	37	15	55727241	55727241	+	Silent	SNP	C	C	T	rs138026922		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:55727241C>T	ENST00000321149.3	-	8	1276	c.909G>A	c.(907-909)acG>acA	p.T303T	DYX1C1_ENST00000380679.1_Silent_p.T303T|DYX1C1_ENST00000448430.2_Silent_p.T303T|DYX1C1_ENST00000457155.2_Silent_p.T303T|DYX1C1-CCPG1_ENST00000565113.1_RNA|DYX1C1_ENST00000348518.3_Silent_p.T303T	NM_130810.3	NP_570722.2	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1	303					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		AATAGTTTTCCGTTGCAAACA	0.318000													18	62					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217124258	217124258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:217124258G>A	ENST00000273067.4	-	4	2776	c.1010C>T	c.(1009-1011)tCc>tTc	p.S337F		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	337						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GGTGGATGAGGAGGTCCGGGG	0.637000													11	29					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41594836	41594836	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41594836C>T	ENST00000330436.3	+	2	183	c.183C>T	c.(181-183)atC>atT	p.I61I		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	61					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	TCCAACAGATCAGTGAGCGCT	0.612000													20	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179553422	179553422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179553422C>T	ENST00000589042.1	-	126	32403	c.32179G>A	c.(32179-32181)Gaa>Aaa	p.E10727K	TTN_ENST00000342992.6_Missense_Mutation_p.E9483K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10410K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10410	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCGTGACTTCCACTCTTTGA	0.388000													34	53					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185902943	185902943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:185902943C>T	ENST00000271588.4	+	11	2044	c.1815C>T	c.(1813-1815)ttC>ttT	p.F605F	HMCN1_ENST00000367492.2_Silent_p.F605F	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	605	Ig-like C2-type 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTTCAGTTTTCCTCACAGTGC	0.398000													50	186					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43251399	43251399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43251399G>A	ENST00000259750.4	+	14	3004	c.2921G>A	c.(2920-2922)gGg>gAg	p.G974E		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	974						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GTGGAGGAGGGGGCCCGAGCG	0.687000													33	44					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23871841	23871841	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23871841C>T	ENST00000354639.3	+	24	3311	c.2847C>T	c.(2845-2847)ttC>ttT	p.F949F	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Silent_p.F949F|STK31_ENST00000355870.3_Silent_p.F972F|STK31_ENST00000428484.1_Silent_p.F949F	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	972	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CTGAATGTTTCTTGATGCCAA	0.353000													24	69					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222821	140222821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140222821G>A	ENST00000531613.1	+	1	1915	c.1915G>A	c.(1915-1917)Gaa>Aaa	p.E639K	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.E639K|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCCTGGACGAAGCGGACTC	0.647000													49	41					0	0	1	0	0
DPT	1805	broad.mit.edu	37	1	168698157	168698157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168698157C>T	ENST00000367817.3	-	1	345	c.256G>A	c.(256-258)Gaa>Aaa	p.E86K		NM_001937.4	NP_001928.2	Q07507	DERM_HUMAN	dermatopontin	86	2 X 53-55 AA tandem repeats.|3 X 6 AA repeats of D-R-[EQ]-W-[NQK]- [FY].				cell adhesion	extracellular space|proteinaceous extracellular matrix				kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					TCCGTGGGTTCCCCGAGGCTC	0.592000													36	65					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594625	140594625	+	Silent	SNP	C	C	T	rs150808997		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140594625C>T	ENST00000341948.4	+	1	1117	c.930C>T	c.(928-930)ttC>ttT	p.F310F		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		310	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.F310F(2)		NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTCGATTTCGAAAAACTTC	0.378000													74	147					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15061170	15061170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15061170C>T	ENST00000430939.2	-	9	1469	c.1340G>A	c.(1339-1341)gGg>gAg	p.G447E	SLC1A6_ENST00000221742.3_Missense_Mutation_p.G511E|SLC1A6_ENST00000600144.1_Missense_Mutation_p.G433E			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	511					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	AATTGAGTCCCCCAGTACGTT	0.567000													21	51					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74347430	74347430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:74347430G>A	ENST00000377044.4	-	7	1939	c.1400C>T	c.(1399-1401)cCt>cTt	p.P467L	TMEM2_ENST00000377066.5_Missense_Mutation_p.P404L	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	467						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CAGGAACTGAGGGGTTTCTGG	0.408000													22	35					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2967321	2967321	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:2967321C>T	ENST00000397461.1	+	12	1600	c.1216C>T	c.(1216-1218)Cca>Tca	p.P406S	CNTN4_ENST00000397459.2_Missense_Mutation_p.P78S|CNTN4_ENST00000418658.1_Missense_Mutation_p.P406S|CNTN4_ENST00000427331.1_Missense_Mutation_p.P406S|CNTN4_ENST00000448906.2_Missense_Mutation_p.P78S|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000358480.3_Missense_Mutation_p.P187S	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	406	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGCTGTAGGTCCAGATTTTTC	0.358000													33	125					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2900696	2900696	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:2900696G>A	ENST00000380698.4	-	2	239	c.150C>T	c.(148-150)acC>acT	p.T50T		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	50					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TCTGGGTTGCGGTGTTTCCCT	0.582000													67	130					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43777460	43777460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43777460C>T	ENST00000389420.3	-	31	4697	c.4698G>A	c.(4696-4698)gtG>gtA	p.V1566V		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1566	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTATTTCATTCACTTGTCTGA	0.368000													11	44					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811088	23811088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23811088G>A	ENST00000314520.3	+	1	635	c.159G>A	c.(157-159)agG>agA	p.R53R	MKRN3_ENST00000568252.1_Silent_p.R53R|MKRN3_ENST00000564592.1_Silent_p.R53R	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	53						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		ATGCGGCAAGGGGCTGGGCCC	0.687000													13	55					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124915205	124915205	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124915205G>A	ENST00000356219.3	-	10	1166	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000405201.1_Silent_p.F337F|NCOR2_ENST00000404621.1_Silent_p.F337F|NCOR2_ENST00000429285.2_Silent_p.F337F|NCOR2_ENST00000397355.1_Silent_p.F337F	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	337					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGATCTCAGGGAACTGCTTCT	0.677000													38	118					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43197462	43197462	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:43197462G>A	ENST00000522175.2	+	0	1215							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACTCAAAATGGATTTTAACGG	0.373000													38	99					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19752519	19752519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:19752519C>T	ENST00000400113.3	-	3	346	c.242G>A	c.(241-243)gGa>gAa	p.G81E		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	81					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CCTATAGGTTCCTGTGCGCAC	0.488000													31	79					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70543268	70543268	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70543268G>A	ENST00000323786.5	-	7	889	c.868C>T	c.(868-870)Cac>Tac	p.H290Y	COG4_ENST00000393612.4_Missense_Mutation_p.H286Y	NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	286					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				ATTGGCTGGTGGGTCTCCACA	0.473000													18	60					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48908153	48908153	+	Missense_Mutation	SNP	G	G	T	rs77698773		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48908153G>T	ENST00000263269.3	+	3	716	c.628G>T	c.(628-630)Ggt>Tgt	p.G210C		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	210						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GCTGACTGACGGTAGTCTGGT	0.662000													36	165					3.33393e-15	3.35151e-15	1	1	0
SEC14L5	9717	broad.mit.edu	37	16	5047039	5047039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:5047039G>A	ENST00000251170.7	+	8	1144	c.964G>A	c.(964-966)Gac>Aac	p.D322N		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	322	CRAL-TRIO.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						GCATTACCAGGACATAGGTGC	0.532000													5	18					0	0	1	0	0
SEPT8	23176	broad.mit.edu	37	5	132100089	132100089	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132100089G>A	ENST00000296873.7	-	3	457	c.174C>T	c.(172-174)tcC>tcT	p.S58S	SEPT8_ENST00000378701.1_Silent_p.S58S|SEPT8_ENST00000378706.1_Silent_p.S58S|SEPT8_ENST00000378719.2_Silent_p.S58S|SEPT8_ENST00000378721.4_Silent_p.S58S|SEPT8_ENST00000378699.2_5'UTR|SEPT8_ENST00000458488.2_Silent_p.S58S|SEPT8_ENST00000448933.1_5'UTR	NM_001098812.1|NM_015146.1	NP_001092282.1|NP_055961.1	Q92599	SEPT8_HUMAN	septin 8	58					cell cycle	septin complex	GTP binding|protein binding		SEPT8/AFF4(2)	kidney(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCATCAGTGTGGATTTGCCAA	0.587000													11	34					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032486	142032486	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142032486G>A	ENST00000547918.2	+	0	339																											AGCGCACACAGCAGGGGGACT	0.557000													12	18					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22157780	22157780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22157780G>A	ENST00000374695.3	-	84	11569	c.11490C>T	c.(11488-11490)atC>atT	p.I3830I		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3830	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CATGGAAGACGATCTCCTCGC	0.677000													17	71					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41496622	41496622	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41496622G>A	ENST00000313860.7	+	2	220	c.167_splice	c.e2+1	p.E56_splice	LIMCH1_ENST00000513024.1_5'UTR|LIMCH1_ENST00000512946.1_Splice_Site_p.E56_splice|LIMCH1_ENST00000512820.1_Splice_Site_p.E56_splice|LIMCH1_ENST00000508501.1_Splice_Site_p.E56_splice|LIMCH1_ENST00000509638.1_Intron|LIMCH1_ENST00000512632.1_Splice_Site_p.E56_splice	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	56	CH.				actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						CCTCCTCTGCGAGTAAGTATA	0.328000													18	45					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186045650	186045650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186045650C>T	ENST00000271588.4	+	54	8610	c.8381C>T	c.(8380-8382)cCc>cTc	p.P2794L	HMCN1_ENST00000367492.2_Missense_Mutation_p.P2794L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2794	Ig-like C2-type 26.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATCAACAATCCCATTTCTCTT	0.433000													33	67					0	0	1	0	0
PPP1R3C	5507	broad.mit.edu	37	10	93390138	93390138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:93390138C>T	ENST00000238994.5	-	2	584	c.500G>A	c.(499-501)cGa>cAa	p.R167Q		NM_005398.5	NP_005389.1	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory subunit 3C	167	CBM21.|Interaction with EPM2A.						protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(1)	12		Colorectal(252;0.235)				TGTCACTGTTCGCTCTTGCAA	0.413000													41	117					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78369603	78369603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78369603G>A	ENST00000278550.7	-	34	8272	c.7810C>T	c.(7810-7812)Cta>Tta	p.L2604L		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AGGTTCTCTAGGTAGTGGGCA	0.542000													12	28					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234855777	234855777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234855777G>A	ENST00000324695.4	+	8	960	c.920G>A	c.(919-921)gGa>gAa	p.G307E	AC005538.5_ENST00000455991.1_RNA|TRPM8_ENST00000433712.2_5'UTR	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	307						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TTTGCCCAAGGAGGTGGAAAA	0.368000													21	50					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13052931	13052931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:13052931G>A	ENST00000399002.2	+	3	605	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K	SPTLC3_ENST00000378194.4_Missense_Mutation_p.E111K	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	111					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	TCAAGACTTTGAAAATTTTTA	0.428000													66	154					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207644767	207644767	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207644767G>A	ENST00000367057.3	+	9	1682		c.e9-1		CR2_ENST00000367058.3_Splice_Site|CR2_ENST00000458541.2_Intron|CR2_ENST00000367059.3_Splice_Site	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2						complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TCTGTCTCTAGGTACAAGTTA	0.438000													55	125					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347469	91347469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91347469C>T	ENST00000358859.2	-	1	1484	c.1051G>A	c.(1051-1053)Gag>Aag	p.E351K	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		CCTCTCTGCTCGTTCTCCTCC	0.488000													26	75					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142237983	142237983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:142237983C>T	ENST00000389484.3	-	3	1296	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	109	LDL-receptor class A 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTACTCCTTCGTCATACCCA	0.413000										TSP Lung(27;0.18)			12	54					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175467	159175467	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159175467C>T	ENST00000537147.1	+	3	1081	c.238C>T	c.(238-240)Ctc>Ttc	p.L80F	DARC_ENST00000368122.2_Missense_Mutation_p.L80F|DARC_ENST00000368121.2_Missense_Mutation_p.L82F			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	80					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					CAGCACTGTCCTCTTCATGCT	0.592000													15	173					0	0	1	0	0
GNG2	54331	broad.mit.edu	37	14	52433336	52433336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52433336C>T	ENST00000335281.4	+	3	553	c.147C>T	c.(145-147)ccC>ccT	p.P49P	GNG2_ENST00000553432.1_Silent_p.P80P|GNG2_ENST00000556766.1_Silent_p.P49P|GNG2_ENST00000555472.1_Silent_p.P49P|GNG2_ENST00000554736.1_Silent_p.P49P|GNG2_ENST00000556752.1_Silent_p.P49P|GNG2_ENST00000557376.1_Silent_p.P88P|GNG2_ENST00000553299.1_3'UTR	NM_001243774.1	NP_001230703.1	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein), gamma 2	49					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity			lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	AGGAAGACCCCCTCCTGACCC	0.522000													43	136					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	95019472	95019472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:95019472G>A	ENST00000265627.5	-	3	205	c.195C>T	c.(193-195)atC>atT	p.I65I	PON1_ENST00000542556.1_Intron|PON3_ENST00000475439.1_5'UTR|PON3_ENST00000427422.1_Silent_p.I65I	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TCACACTGGAGATAAAAGCCA	0.403000													99	287					0	0	1	0	0
GAST	2520	broad.mit.edu	37	17	39872043	39872043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39872043G>A	ENST00000329402.3	+	3	292	c.225G>A	c.(223-225)aaG>aaA	p.K75K	JUP_ENST00000540235.1_Intron	NM_000805.4	NP_000796.1	P01350	GAST_HUMAN	gastrin	75		Cleavage.				extracellular region	hormone activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			CGTCCAAGAAGCAGGGACCAT	0.557000													38	50					0	0	1	0	0
ASAH2	56624	broad.mit.edu	37	10	52003004	52003004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52003004G>A	ENST00000395526.3	-	3	467	c.468C>T	c.(466-468)gtC>gtT	p.V156V	ASAH2_ENST00000329428.6_Silent_p.V137V|ASAH2_ENST00000447815.1_Silent_p.V156V	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	156					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(1)|lung(9)|urinary_tract(1)	11						TGTCGATGCTGACAAACACTG	0.473000													68	173					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50949255	50949255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50949255C>T	ENST00000357701.5	+	12	1303	c.1252C>T	c.(1252-1254)Cgc>Tgc	p.R418C		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	418	Ig-like C2-type 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GGACAGGGGTCGCTATCAGGT	0.597000													5	20					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004579	41004579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41004579G>A	ENST00000399564.4	-	37	4513	c.4063C>T	c.(4063-4065)Cac>Tac	p.H1355Y	MROH2B_ENST00000506092.2_Missense_Mutation_p.H910Y	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CGAGCTAGGTGATACAGGCCT	0.403000													28	64					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1407740	1407740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1407740C>T	ENST00000381524.3	+	6	618	c.432C>T	c.(430-432)gcC>gcT	p.A144A	CSF2RA_ENST00000355805.2_Silent_p.A144A|CSF2RA_ENST00000501036.2_Silent_p.A11A|CSF2RA_ENST00000417535.2_Silent_p.A144A|CSF2RA_ENST00000432318.2_Silent_p.A144A|CSF2RA_ENST00000361536.3_Silent_p.A144A|CSF2RA_ENST00000381500.1_Silent_p.A144A|CSF2RA_ENST00000381509.3_Silent_p.A144A|CSF2RA_ENST00000381529.3_Silent_p.A144A|CSF2RA_ENST00000355432.3_Silent_p.A144A			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	144						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GTCCGACGGCCCCCCGTGACG	0.473000													31	152					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904282	5904282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5904282G>A	ENST00000378961.4	+	4	1696	c.1492G>A	c.(1492-1494)Gaa>Aaa	p.E498K		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	498						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						AAACAGGGAGGAAGCTAGGTT	0.488000													28	62					0	0	1	0	0
HPCAL1	3241	broad.mit.edu	37	2	10560075	10560075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:10560075C>T	ENST00000381765.3	+	4	718	c.192C>T	c.(190-192)ttC>ttT	p.F64F	HPCAL1_ENST00000307845.3_Silent_p.F64F	NM_134421.2	NP_602293.1	P37235	HPCL1_HUMAN	hippocalcin-like 1	64	EF-hand 2.						calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		CTTCCAAGTTCGCCGAGCACG	0.617000													9	79					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73470747	73470747	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73470747C>T	ENST00000252034.7	+	20	1696	c.1297C>T	c.(1297-1299)Ccg>Tcg	p.P433S	ELN_ENST00000380576.5_Missense_Mutation_p.P433S|ELN_ENST00000458204.1_Missense_Mutation_p.P423S|ELN_ENST00000380575.4_Missense_Mutation_p.P423S|ELN_ENST00000320492.7_Intron|ELN_ENST00000414324.1_Missense_Mutation_p.P428S|ELN_ENST00000380553.4_Missense_Mutation_p.P316S|ELN_ENST00000357036.5_Missense_Mutation_p.P438S|ELN_ENST00000429192.1_Missense_Mutation_p.P438S|ELN_ENST00000380584.4_Missense_Mutation_p.P419S|ELN_ENST00000358929.4_Missense_Mutation_p.P433S|ELN_ENST00000445912.1_Missense_Mutation_p.P433S|ELN_ENST00000380562.4_Missense_Mutation_p.P433S|ELN_ENST00000320399.6_Missense_Mutation_p.P433S	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	433	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CGGAGGTGTCCCGGGAGTTGG	0.637000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						44	82					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762606	24762606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24762606G>A	ENST00000376451.2	+	2	710	c.450G>A	c.(448-450)gcG>gcA	p.A150A	KIAA1217_ENST00000307544.6_Silent_p.A150A|KIAA1217_ENST00000376452.3_Silent_p.A432A|KIAA1217_ENST00000458595.1_Silent_p.A432A|KIAA1217_ENST00000376462.1_Silent_p.A352A|KIAA1217_ENST00000430453.2_Silent_p.A353A|KIAA1217_ENST00000376454.3_Silent_p.A432A|KIAA1217_ENST00000396445.1_Silent_p.A150A|KIAA1217_ENST00000396446.1_Silent_p.A150A			Q5T5P2	SKT_HUMAN	KIAA1217	432					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TCCGGTCAGCGAGTGCTTATT	0.507000													22	69					0	0	1	0	0
ADAD2	161931	broad.mit.edu	37	16	84228059	84228059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84228059C>T	ENST00000268624.3	+	3	739	c.646C>T	c.(646-648)Ccc>Tcc	p.P216S	RP11-486L19.2_ENST00000565643.1_RNA|RP11-486L19.2_ENST00000536986.1_RNA|ADAD2_ENST00000315906.5_Missense_Mutation_p.P144S|RP11-486L19.2_ENST00000561900.1_RNA	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	144					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding	p.P216S(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						TCCCTGCTTCCCCTTCTCGGT	0.642000													7	11					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71797676	71797676	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:71797676G>A	ENST00000269500.5	-	4	657	c.322C>T	c.(322-324)Cca>Tca	p.P108S	FBXO15_ENST00000419743.2_Missense_Mutation_p.P184S	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	108										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		GTCTTAACTGGAAGGCCTGTG	0.433000													20	59					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77910348	77910348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77910348C>T	ENST00000302536.2	+	5	957	c.804C>T	c.(802-804)ccC>ccT	p.P268P	VAT1L_ENST00000563850.1_3'UTR	NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	268							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						TTCTCAAACCCCTGGGAACCT	0.473000													23	109					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652070	121652070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121652070C>T	ENST00000393386.2	+	12	3381	c.2970C>T	c.(2968-2970)ctC>ctT	p.L990L	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	990					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CTCATGCCCTCTCTGGTGATG	0.458000													59	129					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277055	114277055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114277055C>T	ENST00000357077.4	+	38	7334	c.7281C>T	c.(7279-7281)gaC>gaT	p.D2427D	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.D2394D|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2394					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGGCTGATGACTCATTAGCAG	0.502000													24	48					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196786849	196786849	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196786849T>C	ENST00000312428.6	-	24	3998	c.3898A>G	c.(3898-3900)Agg>Ggg	p.R1300G		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1300	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATAACCAGCCTAGGGGAATTA	0.343000													20	44					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55445082	55445082	+	Missense_Mutation	SNP	C	C	T	rs142522707	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55445082C>T	ENST00000588756.1	-	10	2983	c.2497G>A	c.(2497-2499)Gcc>Acc	p.A833T	NLRP7_ENST00000328092.5_Missense_Mutation_p.A805T|NLRP7_ENST00000340844.2_Missense_Mutation_p.A833T|NLRP7_ENST00000448121.2_Missense_Mutation_p.A805T|NLRP7_ENST00000590030.1_Missense_Mutation_p.A833T|NLRP7_ENST00000592784.1_Missense_Mutation_p.A833T|NLRP7_ENST00000446217.1_Missense_Mutation_p.A861T			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	833							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TTGCAACTGGCTTCTGTAAGA	0.468000													22	86					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21318838	21318838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:21318838G>A	ENST00000583088.1	+	3	1079	c.184G>A	c.(184-186)Gag>Aag	p.E62K	KCNJ12_ENST00000331718.5_Missense_Mutation_p.E62K	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CAACATGGACGAGAAGTCACA	0.592000										Prostate(3;0.18)			13	41					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1321317	1321317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1321317G>A	ENST00000381567.3	-	4	437	c.438C>T	c.(436-438)ctC>ctT	p.L146L	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Silent_p.L146L	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	146	Fibronectin type-III.					extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CCTCATAGAGGAGATCCCCGT	0.612000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								17	80					0	0	1	0	0
VSX2	338917	broad.mit.edu	37	14	74726416	74726416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74726416C>T	ENST00000261980.2	+	4	781	c.691C>T	c.(691-693)Ccc>Tcc	p.P231S		NM_182894.2	NP_878314.1	P58304	VSX2_HUMAN	visual system homeobox 2	231	CVC.				multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00154)		GCACTCCATCCCCCTGCCCGA	0.647000													21	62					0	0	1	0	0
RECK	8434	broad.mit.edu	37	9	36117063	36117063	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:36117063C>T	ENST00000377966.3	+	17	2708	c.2142C>T	c.(2140-2142)ctC>ctT	p.L714L		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	714	Kazal-like 2.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CAAGACAGCTCGCGTGTGACC	0.458000													21	64					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193166058	193166058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:193166058C>T	ENST00000342695.4	-	18	2411	c.2089G>A	c.(2089-2091)Gaa>Aaa	p.E697K	ATP13A4_ENST00000392443.3_Missense_Mutation_p.E678K	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	697					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TTTGTCTCTTCCTTCAATCGA	0.388000													33	45					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206050515	206050515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206050515C>T	ENST00000406610.2	+	14	2159	c.1952C>T	c.(1951-1953)gCc>gTc	p.A651V	PARD3B_ENST00000351153.1_Missense_Mutation_p.A651V|PARD3B_ENST00000462231.1_Missense_Mutation_p.A651V|PARD3B_ENST00000349953.3_Missense_Mutation_p.A651V|PARD3B_ENST00000358768.2_Missense_Mutation_p.A589V	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	651					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GACGGATGGGCCGAGAGTGAA	0.438000													40	94					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100841514	100841514	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:100841514C>T	ENST00000369208.3	-	11	2201	c.1419G>A	c.(1417-1419)gaG>gaA	p.E473E	SIM1_ENST00000262901.4_Silent_p.E473E			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	473	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		ACCTGCCTGCCTCACATCGGC	0.642000													9	73					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38968367	38968367	+	Silent	SNP	G	G	A	rs113831421		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38968367G>A	ENST00000355481.4	+	30	4442	c.4311G>A	c.(4309-4311)agG>agA	p.R1437R	RYR1_ENST00000359596.3_Silent_p.R1437R|RYR1_ENST00000360985.3_Silent_p.R1437R	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1437	6 X approximate repeats.|B30.2/SPRY 3.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACTCCGTGAGGGTCTTTGCTG	0.597000													11	45					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129875931	129875931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129875931C>T	ENST00000254667.3	+	19	2055	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F	PTPRE_ENST00000306042.5_Silent_p.F534F|PTPRE_ENST00000419012.2_Silent_p.F592F	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	592	Tyrosine-protein phosphatase 2.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				AGTTTCACTTCCACGGCTGGC	0.662000													7	47					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810368	123810368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123810368G>A	ENST00000307033.2	+	1	119	c.45G>A	c.(43-45)ctG>ctA	p.L15L		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTGTTCTACTGGGGCTCTCTC	0.418000													30	84					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87362036	87362036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87362036G>A	ENST00000327946.7	-	16	3109	c.3024C>T	c.(3022-3024)tcC>tcT	p.S1008S	GRID1_ENST00000552278.2_5'UTR|GRID1_ENST00000536331.1_Silent_p.S579S	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	1008						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GCAGTCAGATGGAGGTCCCGT	0.617000										Multiple Myeloma(13;0.14)			8	15					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96698548	96698548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96698548C>T	ENST00000260682.6	+	1	121	c.109C>T	c.(109-111)Cca>Tca	p.P37S	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	37					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	CACTCCTCTCCCAGTGATTGG	0.458000													47	129					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107266583	107266583	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107266583T>C	ENST00000334726.2	+	1	129	c.40T>C	c.(40-42)Ttc>Ctc	p.F14L		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						AGTATTTTTCTTCCTGGGATT	0.383000													10	70					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113464984	113464984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113464984C>T	ENST00000487903.1	+	5	473	c.385C>T	c.(385-387)Cct>Tct	p.P129S	ATP11A_ENST00000375645.3_Missense_Mutation_p.P129S|ATP11A_ENST00000375630.2_Missense_Mutation_p.P129S|ATP11A_ENST00000283558.8_Missense_Mutation_p.P129S			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	129					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GAACCAGTGTCCTGTTCATTT	0.473000													16	146					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4853129	4853129	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4853129G>A	ENST00000354582.6	+	55	7758	c.7408G>A	c.(7408-7410)Gaa>Aaa	p.E2470K	ITPR1_ENST00000456211.2_Missense_Mutation_p.E2422K|ITPR1_ENST00000443694.2_Missense_Mutation_p.E2470K|ITPR1_ENST00000463980.1_3'UTR|ITPR1_ENST00000544951.1_Missense_Mutation_p.E448K|ITPR1_ENST00000357086.4_Missense_Mutation_p.E2437K|ITPR1_ENST00000423119.2_Missense_Mutation_p.E2437K|ITPR1_ENST00000302640.8_Missense_Mutation_p.E2470K			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2485					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GCTGCCCAATGAAACAGCTGT	0.383000													27	81					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082505	9082505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9082505C>T	ENST00000397910.4	-	1	9513	c.9310G>A	c.(9310-9312)Gag>Aag	p.E3104K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3105	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGTTCCCTCTTCTTCTGCA	0.488000													82	212					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10155574	10155574	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10155574C>T	ENST00000343090.6	+	3	342	c.267C>T	c.(265-267)ccC>ccT	p.P89P	UBE4B_ENST00000253251.8_Silent_p.P89P|UBE4B_ENST00000377157.3_5'UTR	NM_001105562.2	NP_001099032.1	O95155	UBE4B_HUMAN	ubiquitination factor E4B	89					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GCAGCTCGCCCTCTAATAGCC	0.468000													8	101					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57132039	57132039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:57132039G>A	ENST00000296318.7	-	12	1780	c.1692C>T	c.(1690-1692)ttC>ttT	p.F564F	IL17RD_ENST00000427856.2_Silent_p.F540F|IL17RD_ENST00000463523.1_Silent_p.F420F|IL17RD_ENST00000320057.5_Silent_p.F420F	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	564						Golgi membrane|integral to membrane|plasma membrane	receptor activity	p.F420F(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		GGAAGGGAACGAACTGCTTTT	0.527000													10	42					0	0	1	0	0
HDGFRP3	50810	broad.mit.edu	37	15	83820065	83820065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83820065C>T	ENST00000299633.4	-	5	1111	c.508G>A	c.(508-510)Gac>Aac	p.D170N		NM_016073.3	NP_057157.1	Q9Y3E1	HDGR3_HUMAN		170					cell proliferation	nucleus	growth factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						TCTTTGCAGTCTTTGTCATCT	0.408000													16	133					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111156206	111156206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111156206C>T	ENST00000360467.5	+	44	4457	c.4151C>T	c.(4150-4152)aCt>aTt	p.T1384I	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1384	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GCCCCCGGGACTGTGGGAGCC	0.652000													20	73					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21876619	21876619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21876619G>A	ENST00000399982.2	-	12	2646	c.2582C>T	c.(2581-2583)cCc>cTc	p.P861L	CHD8_ENST00000430710.3_Missense_Mutation_p.P582L|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000557364.1_Missense_Mutation_p.P861L	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	861	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GACCAAGAAGGGACCATGGAT	0.468000													12	77					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69699102	69699102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69699102C>T	ENST00000194900.4	+	11	1903	c.1562C>T	c.(1561-1563)tCc>tTc	p.S521F	DLG3_ENST00000542398.1_Missense_Mutation_p.S20F|DLG3_ENST00000374360.3_Missense_Mutation_p.S503F|DLG3_ENST00000374355.3_Missense_Mutation_p.S166F			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	503	SH3.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					GAAAAGAGGTCCTTGTATGTC	0.493000													40	29					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158587369	158587369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158587369G>A	ENST00000368148.3	-	47	6738	c.6558C>T	c.(6556-6558)ctC>ctT	p.L2186L	SPTA1_ENST00000368147.3_Silent_p.L2183L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2186					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTGTTTCTTTGAGCAATGATC	0.343000													18	39					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884436	24884436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24884436C>T	ENST00000382554.3	+	9	3799	c.3481C>T	c.(3481-3483)Cgc>Tgc	p.R1161C		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1161					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GCTGCCCTTCCGCCTGGAGGT	0.647000													25	61					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83437738	83437738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83437738C>T	ENST00000334574.8	-	9	1628	c.1447G>A	c.(1447-1449)Gaa>Aaa	p.E483K	FSD2_ENST00000541889.1_Missense_Mutation_p.E438K			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	483	Fibronectin type-III 2.									breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						ACAGCCTCTTCACAGCTCCTT	0.493000													6	25					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111158873	111158873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111158873C>T	ENST00000360467.5	+	46	4820	c.4514C>T	c.(4513-4515)cCa>cTa	p.P1505L	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1505	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCCATGTGCCCAGTGGGCATG	0.652000													4	27					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921425	24921425	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24921425C>T	ENST00000329468.2	+	1	885	c.411C>T	c.(409-411)gcC>gcT	p.A137A		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CGGTCAAGGCCAGGAAGCCCA	0.622000													17	53					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940754	22940754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22940754C>T	ENST00000397104.3	-	5	1683	c.1684G>A	c.(1684-1686)Gaa>Aaa	p.E562K	ZNF99_ENST00000596209.1_Missense_Mutation_p.E653K					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTACCACATTCTTCACATTTG	0.383000													21	76					0	0	1	0	0
VDR	7421	broad.mit.edu	37	12	48240513	48240513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48240513G>A	ENST00000229022.3	-	9	1115	c.834C>T	c.(832-834)tcC>tcT	p.S278S	VDR_ENST00000549336.1_Silent_p.S278S|VDR_ENST00000550325.1_Silent_p.S328S|VDR_ENST00000395324.2_Silent_p.S278S|VDR_ENST00000535672.1_Silent_p.S246S	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	278	Ligand-binding.|Vitamin D3 binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CCATGGTGAAGGACTCATTGG	0.552000													27	67					0	0	1	0	0
ZIC3	7547	broad.mit.edu	37	X	136649320	136649320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:136649320C>T	ENST00000287538.5	+	1	1020	c.470C>T	c.(469-471)cCt>cTt	p.P157L	ZIC3_ENST00000370606.3_Missense_Mutation_p.P157L	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	157					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					CCCGAGCCCCCTAGCTACTTG	0.711000													20	7					0	0	1	0	0
ZNF431	170959	broad.mit.edu	37	19	21366005	21366005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21366005C>T	ENST00000311048.7	+	5	1043	c.899C>T	c.(898-900)tCc>tTc	p.S300F	ZNF431_ENST00000594425.1_Intron|ZNF431_ENST00000600692.1_3'UTR	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						TTCAACCGGTCCTCACACCTT	0.398000													22	86					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3681616	3681616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:3681616C>T	ENST00000404826.2	+	4	731	c.592C>T	c.(592-594)Cag>Tag	p.Q198*	SDK1_ENST00000389531.3_Nonsense_Mutation_p.Q198*	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	198	Ig-like C2-type 2.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGATACGGACCAGAGGAAAAC	0.468000													13	66					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113935433	113935433	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:113935433A>T	ENST00000348367.4	-	6	535	c.338T>A	c.(337-339)cTt>cAt	p.L113H	GPAM_ENST00000423155.1_Missense_Mutation_p.L113H|GPAM_ENST00000369425.1_Missense_Mutation_p.L113H			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	113					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TTGAATAAAAAGAACGTAAGA	0.443000													40	89					0	0	1	0	0
EFS	10278	broad.mit.edu	37	14	23828896	23828896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23828896G>A	ENST00000216733.3	-	4	1398	c.791C>T	c.(790-792)cCt>cTt	p.P264L	EFS_ENST00000429593.2_Missense_Mutation_p.P95L|EFS_ENST00000351354.3_Missense_Mutation_p.P171L	NM_005864.2	NP_005855.1	O43281	EFS_HUMAN	embryonal Fyn-associated substrate	264	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)	16	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		CTCTGGAGAAGGGGGAGCCTC	0.672000													22	44					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68244848	68244848	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:68244848G>A	ENST00000347230.4	-	24	4930	c.4792C>T	c.(4792-4794)Ctg>Ttg	p.L1598L	ZFYVE26_ENST00000555452.1_Silent_p.L1598L	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1598					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTTACTTGCAGAGCCTTGTCA	0.433000													10	168					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143853238	143853238	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:143853238G>A	ENST00000507359.2	+	3	1939	c.848G>A	c.(847-849)tGg>tAg	p.W283*	KCTD16_ENST00000512467.1_Nonsense_Mutation_p.W283*	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16	283						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			CCTTCCAGATGGTCACCCTCA	0.507000													24	69					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1658192	1658192	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1658192G>A	ENST00000252804.4	-	15	1976	c.1926C>T	c.(1924-1926)acC>acT	p.T642T		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	642					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AATGTGTTCGGGTTGAGTTTA	0.468000													6	46					0	0	1	0	0
SEC1P	653677	broad.mit.edu	37	19	49183940	49183940	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49183940G>A	ENST00000430145.2	+	0	1027					NR_004401.2																						TACCTGCAGCGGGCCCTGGAC	0.692000													3	3					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117691445	117691445	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117691445C>T	ENST00000317775.6	-	17	3331	c.2646G>A	c.(2644-2646)gtG>gtA	p.V882V	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.V916V	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	882	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTGCTCACCTCACATTGGCCA	0.557000													23	78					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123494522	123494522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123494522G>A	ENST00000280562.5	-	5	723	c.518C>T	c.(517-519)tCc>tTc	p.S173F	PITPNM2_ENST00000320201.4_Missense_Mutation_p.S173F|PITPNM2_ENST00000546049.1_Missense_Mutation_p.S173F|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Missense_Mutation_p.S173F			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	173					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CCAGTTCTCGGACAGGGGCCC	0.552000													72	138					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35827133	35827133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35827133G>A	ENST00000085219.5	+	4	673	c.607G>A	c.(607-609)Gag>Aag	p.E203K	CD22_ENST00000536635.2_Missense_Mutation_p.E203K|CD22_ENST00000270311.6_Missense_Mutation_p.E83K|CD22_ENST00000544992.2_Missense_Mutation_p.E203K|CD22_ENST00000594250.1_Missense_Mutation_p.E203K|CD22_ENST00000419549.2_Missense_Mutation_p.E31K|CD22_ENST00000341773.6_Missense_Mutation_p.E203K	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	203	Ig-like C2-type 1.		E -> K.		cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CACCCGGAGCGAGCTCAAGTT	0.557000													30	64					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110864539	110864539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110864539C>T	ENST00000265171.5	+	3	902	c.457C>T	c.(457-459)Ctt>Ttt	p.L153F	EGF_ENST00000502723.1_3'UTR|EGF_ENST00000509793.1_Missense_Mutation_p.L153F|EGF_ENST00000503392.1_Missense_Mutation_p.L153F	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	153					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TTCCCACATTCTTTTAAGTGC	0.308000													20	84					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101493479	101493479	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101493479C>T	ENST00000392979.3	+	21	2386	c.2025C>T	c.(2023-2025)ttC>ttT	p.F675F	ANO4_ENST00000392977.3_Silent_p.F710F|ANO4_ENST00000550015.1_Silent_p.F230F|ANO4_ENST00000299222.9_Silent_p.F230F	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	710						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						ATGGACTCTTCGATGAATACT	0.333000										HNSCC(74;0.22)			49	28					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026768	79026768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79026768C>T	ENST00000446378.2	+	2	2211	c.2180C>T	c.(2179-2181)tCt>tTt	p.S727F		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	727						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAAGGTGTTTCTGAGTACATG	0.453000													30	60					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1953644	1953644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1953644G>A	ENST00000382722.5	-	25	2756	c.2394C>T	c.(2392-2394)ttC>ttT	p.F798F	CACNA2D4_ENST00000585708.1_Silent_p.F734F|CACNA2D4_ENST00000585732.1_Silent_p.F659F|CACNA2D4_ENST00000586184.1_Silent_p.F798F|CACNA2D4_ENST00000588077.1_Silent_p.F734F|CACNA2D4_ENST00000539048.2_5'UTR|CACNA2D4_ENST00000587995.1_Silent_p.F773F	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	798						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		ACCACAGCGGGAAGCGGTCCA	0.612000													13	24					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8808164	8808164	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8808164G>A	ENST00000447110.1	-	5	466	c.342C>T	c.(340-342)acC>acT	p.T114T	PIK3R5_ENST00000584803.1_Silent_p.T114T|PIK3R5_ENST00000581552.1_Silent_p.T114T	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	114					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						GAACAGGCCAGGTCAGGAACC	0.577000													13	52					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126132589	126132589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126132589C>T	ENST00000373631.3	+	7	1258	c.1257C>T	c.(1255-1257)gtC>gtT	p.V419V	CRB2_ENST00000373629.2_Silent_p.V87V|CRB2_ENST00000359999.3_Silent_p.V419V	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	419	EGF-like 9.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						AGTCTGGGGTCCACAGTTACG	0.622000													8	41					0	0	1	0	0
SHD	56961	broad.mit.edu	37	19	4283066	4283066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4283066G>A	ENST00000543264.2	+	3	1882	c.419G>A	c.(418-420)gGg>gAg	p.G140E	SHD_ENST00000599689.1_Missense_Mutation_p.G140E	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	140										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGGCAGAGGGGTGCAGCTC	0.612000													6	57					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43866259	43866259	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43866259G>A	ENST00000378009.4	+	0	1262				CTC-490G23.4_ENST00000607109.1_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CCACCAAAATGAGCATTCAGG	0.557000													7	88					0	0	1	0	0
GP6	51206	broad.mit.edu	37	19	55543725	55543725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55543725G>A	ENST00000310373.3	-	3	134	c.107C>T	c.(106-108)tCc>tTc	p.S36F	GP6_ENST00000417454.1_Missense_Mutation_p.S36F|CTC-550B14.7_ENST00000586845.1_RNA|CTC-550B14.7_ENST00000593060.1_RNA|CTC-550B14.7_ENST00000586961.1_RNA|CTC-550B14.6_ENST00000585492.1_RNA|GP6_ENST00000333884.2_Missense_Mutation_p.S36F	NM_001083899.1	NP_001077368.1	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	36	Ig-like C2-type 1.				enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		GGGCACCAGGGAGCTGGGCAG	0.697000													7	24					0	0	1	0	0
STAU2	27067	broad.mit.edu	37	8	74600939	74600939	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:74600939A>G	ENST00000355780.5	-	4	346	c.128T>C	c.(127-129)cTt>cCt	p.L43P	STAU2_ENST00000522509.1_Missense_Mutation_p.L43P|STAU2_ENST00000522695.1_Missense_Mutation_p.L43P|STAU2_ENST00000517542.1_Missense_Mutation_p.L37P|RP11-463D19.1_ENST00000533978.1_lincRNA|STAU2_ENST00000523558.1_Intron|STAU2_ENST00000524104.1_Missense_Mutation_p.L43P|STAU2_ENST00000521451.1_Intron|STAU2_ENST00000521419.1_Missense_Mutation_p.L37P|STAU2_ENST00000521210.1_Intron|STAU2_ENST00000519961.1_Missense_Mutation_p.L75P|STAU2_ENST00000521727.1_Missense_Mutation_p.L55P|STAU2_ENST00000524300.1_Missense_Mutation_p.L75P|RP11-463D19.2_ENST00000358757.5_3'UTR|STAU2_ENST00000522962.1_5'UTR	NM_014393.2	NP_055208.2	Q9NUL3	STAU2_HUMAN	staufen double-stranded RNA binding protein 2	75	DRBM 1.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)	19	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TGGTTTGGGAAGCGTAGATTC	0.463000													40	205					0	0	1	0	0
FOXJ1	2302	broad.mit.edu	37	17	74134103	74134103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74134103G>A	ENST00000322957.6	-	3	951	c.597C>T	c.(595-597)ccC>ccT	p.P199P		NM_001454.3	NP_001445.2	Q92949	FOXJ1_HUMAN	forkhead box J1	199					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|liver(1)|pancreas(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(166;0.187)			CCGCGTACTGGGGGTCAATGC	0.622000													14	25					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2820047	2820047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2820047G>A	ENST00000520002.1	-	62	10127	c.9572C>T	c.(9571-9573)tCc>tTc	p.S3191F	CSMD1_ENST00000542608.1_Missense_Mutation_p.S3013F|CSMD1_ENST00000400186.3_Missense_Mutation_p.S3014F|CSMD1_ENST00000602557.1_Missense_Mutation_p.S3191F|CSMD1_ENST00000537824.1_Missense_Mutation_p.S3190F|CSMD1_ENST00000602723.1_Missense_Mutation_p.S3014F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3191	Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCTTCTGGAGGATCCCACGAG	0.502000													10	30					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29295045	29295045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29295045C>T	ENST00000331664.5	-	1	2082	c.2083G>A	c.(2083-2085)Gaa>Aaa	p.E695K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	695					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TTGCCTTGTTCGTCCTCAGGA	0.537000													25	103					0	0	1	0	0
C3orf18	51161	broad.mit.edu	37	3	50602982	50602982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50602982G>A	ENST00000357203.3	-	3	688	c.149C>T	c.(148-150)cCt>cTt	p.P50L	C3orf18_ENST00000441239.1_Missense_Mutation_p.P50L|C3orf18_ENST00000449241.1_Missense_Mutation_p.P50L|C3orf18_ENST00000426034.1_Missense_Mutation_p.P50L|C3orf18_ENST00000486175.1_Intron	NM_016210.4	NP_057294.2	Q9UK00	CC018_HUMAN	chromosome 3 open reading frame 18	50						integral to membrane				lung(1)|pancreas(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.0175)|Kidney(197;0.0207)		AGCTGCATCAGGGATTCTGGT	0.607000													15	38					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13770902	13770902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13770902G>A	ENST00000265104.4	-	56	9665	c.9561C>T	c.(9559-9561)ttC>ttT	p.F3187F	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3187	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTCCATATATGAACTTATAGC	0.458000									Kartagener syndrome				28	61					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183696240	183696240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183696240G>A	ENST00000511685.1	+	24	5361	c.5238G>A	c.(5236-5238)ttG>ttA	p.L1746L	TENM3_ENST00000406950.2_Silent_p.L1746L					teneurin transmembrane protein 3																		GTCAAAACTTGGTGGAATGGA	0.522000													25	61					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144856938	144856938	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:144856938G>A	ENST00000369359.4	-	43	6993	c.6955C>T	c.(6955-6957)Cac>Tac	p.H2319Y	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.H2183Y|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.H2077Y|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.H2268Y|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.H2183Y|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2183					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCATCAATGTGGCCAATGACA	0.517000			T	PDGFRB	MPD								8	66					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	114141204	114141204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:114141204C>T	ENST00000371950.3	+	6	1232	c.508C>T	c.(508-510)Cgt>Tgt	p.R170C	HTR2C_ENST00000371951.1_Silent_p.F201F|HTR2C_ENST00000276198.1_Silent_p.F201F	NM_001256761.1	NP_001243690.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	0					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	AAAAGGTGTTCGTGAACAACA	0.448000													70	53					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92088158	92088158	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92088158C>T	ENST00000298047.6	+	1	2897	c.2880C>T	c.(2878-2880)acC>acT	p.T960T	FAT3_ENST00000525166.1_Silent_p.T810T|FAT3_ENST00000409404.2_Silent_p.T960T|FAT3_ENST00000541502.1_Silent_p.T960T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	960	Cadherin 9.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGCTTGAGACCCATGATCCAG	0.463000										TCGA Ovarian(4;0.039)			29	77					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39022673	39022673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39022673C>T	ENST00000379907.4	+	9	918	c.791C>T	c.(790-792)tCt>tTt	p.S264F	ADAM32_ENST00000437682.2_Missense_Mutation_p.S271F|ADAM32_ENST00000519315.1_Missense_Mutation_p.S264F	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	264	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGGAAACAATCTTATCTTAAC	0.308000													19	38					0	0	1	0	0
MMP24	10893	broad.mit.edu	37	20	33842389	33842389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33842389G>A	ENST00000246186.6	+	4	734	c.649G>A	c.(649-651)Gag>Aag	p.E217K	EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000438751.1_RNA|MMP24-AS1_ENST00000433764.1_RNA|MMP24-AS1_ENST00000566203.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	217					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TGACCGGAAGGAGGCAGACAT	0.537000													63	230					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41021242	41021242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41021242G>A	ENST00000352632.3	+	15	2876	c.2790G>A	c.(2788-2790)atG>atA	p.M930I	SPTBN4_ENST00000598249.1_Missense_Mutation_p.M930I|SPTBN4_ENST00000595535.1_Missense_Mutation_p.M930I|SPTBN4_ENST00000344104.3_Missense_Mutation_p.M930I|SPTBN4_ENST00000338932.3_Missense_Mutation_p.M930I			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	930					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACCAAGAGATGAACAGCCTGA	0.562000													7	15					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32745514	32745514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32745514G>A	ENST00000333070.4	+	11	1304	c.1204G>A	c.(1204-1206)Gtg>Atg	p.V402M	LCK_ENST00000373564.3_Missense_Mutation_p.V379M|LCK_ENST00000336890.5_Missense_Mutation_p.V372M	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	372	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	CAACATTCTGGTGTCTGACAC	0.517000			T	TRB@	T-ALL								42	79					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594212	179594212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179594212C>T	ENST00000589042.1	-	64	18895	c.18671G>A	c.(18670-18672)gGa>gAa	p.G6224E	TTN_ENST00000342992.6_Missense_Mutation_p.G4980E|TTN_ENST00000591111.1_Missense_Mutation_p.G5907E|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5907	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGAGGTGTTCCCGTAACTTC	0.443000													27	104					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91348352	91348352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91348352G>A	ENST00000358859.2	-	1	601	c.168C>T	c.(166-168)ccC>ccT	p.P56P	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		ACTCGGTCTTGGGGCTATATC	0.642000													10	28					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153751848	153751848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153751848C>T	ENST00000271857.2	+	9	2918	c.2158C>T	c.(2158-2160)Cta>Tta	p.L720L	SLC27A3_ENST00000368661.3_Silent_p.L639L|SLC27A3_ENST00000484014.1_3'UTR			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	639					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AATGGCAGCCCTAGTTCTGCG	0.627000													31	80					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18889628	18889628	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18889628C>T	ENST00000380548.4	+	25	4864	c.4525C>T	c.(4525-4527)Cag>Tag	p.Q1509*	ADAMTSL1_ENST00000380545.5_Nonsense_Mutation_p.Q210*	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1509						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCGGGGGGTTCAGCAGCCCCG	0.607000													5	31					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11725780	11725780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11725780G>A	ENST00000262442.3	+	47	8944	c.8876G>A	c.(8875-8877)gGa>gAa	p.G2959E	DNAH9_ENST00000454412.2_Missense_Mutation_p.G2959E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2959	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCCCCTGTGGGAAACAAGCTA	0.542000													13	89					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166183422	166183422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166183422G>A	ENST00000357398.3	+	13	2367	c.2077G>A	c.(2077-2079)Gat>Aat	p.D693N	SCN2A_ENST00000375437.2_Missense_Mutation_p.D693N|SCN2A_ENST00000375427.2_Missense_Mutation_p.D693N|SCN2A_ENST00000283256.6_Missense_Mutation_p.D693N			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	693					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TGTTTCCATGGATTTATTGGA	0.373000													13	136					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173556803	173556803	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173556803C>T	ENST00000367714.3	-	5	946		c.e5+1		RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Splice_Site	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)						sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										ATGTGACATACCAATAGTTTT	0.318000													24	59					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167170	140167170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140167170C>T	ENST00000504120.2	+	1	1295	c.1295C>T	c.(1294-1296)tCg>tTg	p.S432L	PCDHA1_ENST00000378133.3_Missense_Mutation_p.S432L|PCDHA1_ENST00000394633.3_Missense_Mutation_p.S432L	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGGGGGCTCGCCTTCGCTG	0.632000													55	151					0	0	1	0	0
DRAXIN	374946	broad.mit.edu	37	1	11766354	11766354	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11766354C>T	ENST00000294485.5	+	2	174	c.39C>T	c.(37-39)ttC>ttT	p.F13F		NM_198545.3	NP_940947.3			dorsal inhibitory axon guidance protein																		CCATGCTGTTCCTCGTCCTCC	0.652000													10	22					0	0	1	0	0
DPPA3	359787	broad.mit.edu	37	12	7864234	7864234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7864234C>T	ENST00000345088.2	+	1	185	c.68C>T	c.(67-69)tCc>tTc	p.S23F		NM_199286.2	NP_954980.1	Q6W0C5	DPPA3_HUMAN	developmental pluripotency associated 3	23						cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)	8				Kidney(36;0.0887)		GAAGAAAATTCCCGGGACGAT	0.468000													19	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069056	9069056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9069056G>A	ENST00000397910.4	-	3	18593	c.18390C>T	c.(18388-18390)tcC>tcT	p.S6130S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6132	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAATGTCTGGGGACTTTGTTG	0.507000													6	29					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165559709	165559709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165559709G>A	ENST00000342193.4	-	9	1462	c.1247C>T	c.(1246-1248)tCc>tTc	p.S416F	COBLL1_ENST00000409184.3_Intron|COBLL1_ENST00000392717.2_Missense_Mutation_p.S454F|COBLL1_ENST00000375458.2_Intron|COBLL1_ENST00000194871.6_Missense_Mutation_p.S482F|COBLL1_ENST00000491126.2_Intron	NM_014900.3	NP_055715.3	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	454										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						CTCCTGACTGGAAAGCCCAGG	0.488000													13	121					0	0	1	0	0
CEP70	80321	broad.mit.edu	37	3	138219681	138219681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138219681G>A	ENST00000264982.3	-	14	1530	c.1264C>T	c.(1264-1266)Cct>Tct	p.P422S	CEP70_ENST00000481834.1_Missense_Mutation_p.P422S|CEP70_ENST00000484888.1_Missense_Mutation_p.P422S|CEP70_ENST00000542237.1_Missense_Mutation_p.P402S|CEP70_ENST00000489254.1_Missense_Mutation_p.P270S	NM_024491.2	NP_077817.2	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70kDa	422					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	24						TTAAGCCAAGGTACCAGTTCT	0.289000													18	88					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600269	29600269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29600269G>A	ENST00000431530.3	+	1	1522	c.1464G>A	c.(1462-1464)gaG>gaA	p.E488E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	478						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CTGTTGGAGAGAACAAGACGG	0.527000													17	52					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50964978	50964978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50964978G>A	ENST00000374103.4	-	3	304	c.219C>T	c.(217-219)ttC>ttT	p.F73F	OGDHL_ENST00000419399.1_Intron|OGDHL_ENST00000432695.1_Intron	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	73					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CTTCCCTGAAGAAGCTGTCCC	0.612000													17	61					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43753352	43753352	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:43753352T>G	ENST00000458276.2	+	4	781	c.658T>G	c.(658-660)Ttt>Gtt	p.F220V		NM_016006.4	NP_057090.2	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	220					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			kidney(3)|large_intestine(2)|liver(2)|lung(5)|ovary(1)|skin(1)	14		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		TGCAGGACCCTTTGGTGAGTG	0.403000													52	113					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210856647	210856647	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210856647C>T	ENST00000367007.4	-	11	3034	c.2865G>A	c.(2863-2865)gaG>gaA	p.E955E	KCNH1_ENST00000271751.4_Silent_p.E982E	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	982	CAD (involved in subunit assembly) (By similarity).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AAATGTCTCTCTCTGATTCTG	0.463000													16	241					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79365015	79365015	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79365015G>A	ENST00000444841.1	-	0	166																											TTTCTCAAGTGAACTCATATG	0.458000													3	5					0	0	1	0	0
HEYL	26508	broad.mit.edu	37	1	40092724	40092724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40092724G>A	ENST00000372852.3	-	5	761	c.442C>T	c.(442-444)Cgc>Tgc	p.R148C	HEYL_ENST00000535435.1_Missense_Mutation_p.R120C	NM_014571.3	NP_055386.1	Q9NQ87	HEYL_HUMAN	hes-related family bHLH transcription factor with YRPW motif-like	148	Orange.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAGAGAAGGCGAATCCGGACG	0.627000													18	48					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083611	9083611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9083611G>A	ENST00000397910.4	-	1	8407	c.8204C>T	c.(8203-8205)cCa>cTa	p.P2735L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2735	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTATTCCGTGGAGCAACAAT	0.463000													37	84					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129915067	129915067	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129915067G>A	ENST00000222481.4	+	6	620	c.565G>A	c.(565-567)Gca>Aca	p.A189T		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	189					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					ACAAGCTACGGCACTTTGGAC	0.502000													11	45					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242082349	242082349	+	Silent	SNP	G	G	A	rs145347607		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242082349G>A	ENST00000403638.3	-	2	190	c.99C>T	c.(97-99)acC>acT	p.T33T	PASK_ENST00000539818.1_Intron|PASK_ENST00000544142.1_5'UTR|PASK_ENST00000358649.4_Silent_p.T33T|PASK_ENST00000405260.1_Silent_p.T33T|PASK_ENST00000234040.4_Silent_p.T33T	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	33					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCTCAGCAGTGGTCTGTGCAG	0.597000													7	52					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154306661	154306661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154306661C>T	ENST00000368489.3	+	10	767	c.767C>T	c.(766-768)cCt>cTt	p.P256L	ATP8B2_ENST00000341822.2_Missense_Mutation_p.P242L|ATP8B2_ENST00000368487.3_Missense_Mutation_p.P223L|ATP8B2_ENST00000426445.1_3'UTR	NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	242					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AATAAGTTCCCTCTGAGCAAC	0.517000													30	327					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126705672	126705672	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:126705672G>A	ENST00000274473.6	+	6	657	c.390G>A	c.(388-390)tgG>tgA	p.W130*	MEGF10_ENST00000508365.1_Nonsense_Mutation_p.W130*|MEGF10_ENST00000418761.2_Nonsense_Mutation_p.W130*|MEGF10_ENST00000503335.2_Nonsense_Mutation_p.W130*	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	130	EGF-like 1.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGCCTGGCTGGGGAGGGACCA	0.507000													9	61					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33466326	33466326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33466326G>A	ENST00000379471.2	-	17	2276	c.2189C>T	c.(2188-2190)gCc>gTc	p.A730V	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000455041.2_Missense_Mutation_p.A678V			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	730					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CTCCACGTAGGCCGGACAGGG	0.612000											OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	97					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369669	56369669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56369669G>A	ENST00000301295.6	+	3	1332	c.910G>A	c.(910-912)Gag>Aag	p.E304K	NLRP4_ENST00000587891.1_Missense_Mutation_p.E229K|NLRP4_ENST00000346986.5_Missense_Mutation_p.E304K	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	304	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGGATTCAACGAGAGTGATAG	0.507000													25	63					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75900467	75900467	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:75900467G>A	ENST00000377636.3	-	10	2245	c.1899C>T	c.(1897-1899)tcC>tcT	p.S633S	TBC1D4_ENST00000431480.2_Silent_p.S633S|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000377625.2_Silent_p.S633S	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	633						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GAAACTGCGGGGAGTCGGAAT	0.582000													16	44					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40208396	40208396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:40208396G>A	ENST00000302541.6	+	6	952	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	MYRIP_ENST00000444716.1_Missense_Mutation_p.E204K|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Missense_Mutation_p.E115K|MYRIP_ENST00000539167.1_Missense_Mutation_p.E17K|MYRIP_ENST00000425621.1_Missense_Mutation_p.E204K	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	204	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GGCCATTGAGGAAGCAATTTC	0.552000													27	70					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450703	55450703	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55450703C>T	ENST00000588756.1	-	6	1970	c.1484G>A	c.(1483-1485)tGg>tAg	p.W495*	NLRP7_ENST00000328092.5_Nonsense_Mutation_p.W495*|NLRP7_ENST00000340844.2_Nonsense_Mutation_p.W495*|NLRP7_ENST00000448121.2_Nonsense_Mutation_p.W495*|NLRP7_ENST00000590030.1_Nonsense_Mutation_p.W495*|NLRP7_ENST00000592784.1_Nonsense_Mutation_p.W495*|NLRP7_ENST00000446217.1_Nonsense_Mutation_p.W523*			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	495							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CCCGATGTCCCAGGCGTGGCC	0.572000													7	96					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26343785	26343785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26343785C>T	ENST00000335473.7	+	36	5989	c.5739C>T	c.(5737-5739)ctC>ctT	p.L1913L	MYO18B_ENST00000536101.1_Silent_p.L1913L|MYO18B_ENST00000407587.2_Silent_p.L1914L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1913	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						ACAAGGACCTCATTGCTCAGG	0.537000													10	30					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70841825	70841825	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70841825G>A	ENST00000393567.2	-	86	15174	c.15024C>T	c.(15022-15024)ctC>ctT	p.L5008L		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	5008										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CTCCACCTGCGAGCGATGATA	0.587000													16	76					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707809	50707809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50707809C>T	ENST00000330943.4	-	4	630	c.459G>A	c.(457-459)atG>atA	p.M153I	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	153	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						GCTCACAGATCATCTCCTCAG	0.632000													10	31					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144917573	144917573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:144917573G>A	ENST00000529945.1	-	8	2459	c.2020C>T	c.(2020-2022)Ctt>Ttt	p.L674F	PDE4DIP_ENST00000313431.9_Missense_Mutation_p.L674F|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.L298F|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.L511F|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.L577F|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.L511F|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.L648F|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.L648F|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.L511F|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.L511F			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	511					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTCACAGCAAGACGAAGCTGG	0.448000			T	PDGFRB	MPD								19	491					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128509	152128509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152128509C>T	ENST00000316073.3	-	3	1130	c.1066G>A	c.(1066-1068)Gat>Aat	p.D356N		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	356	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding	p.D356N(1)		breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TTTGTCTGATCATAATGATAA	0.488000													323	732					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90020763	90020763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90020763C>T	ENST00000405460.2	+	46	9959	c.9863C>T	c.(9862-9864)tCt>tTt	p.S3288F		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3288					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGAAAATCATCTGTTACTGTT	0.294000													18	45					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145094856	145094856	+	Silent	SNP	C	C	T	rs60729674	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145094856C>T	ENST00000377470.3	+	2	360	c.258C>T	c.(256-258)ctC>ctT	p.L86L	SPATC1_ENST00000447830.2_Silent_p.L86L	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	86										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AACGAGTCCTCGAAGAAGTGG	0.642000													26	84					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39788323	39788323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:39788323C>T	ENST00000564288.1	+	32	4850	c.4073C>T	c.(4072-4074)tCg>tTg	p.S1358L	MACF1_ENST00000545844.1_Missense_Mutation_p.S1363L|MACF1_ENST00000539005.1_Missense_Mutation_p.S1363L|MACF1_ENST00000372915.3_Missense_Mutation_p.S1363L|MACF1_ENST00000361689.2_Missense_Mutation_p.S1363L|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000317713.7_Missense_Mutation_p.S1363L|MACF1_ENST00000567887.1_Missense_Mutation_p.S1395L			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	1363					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding	p.S1363L(1)		breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTGTGGAATCGCAGCAGAAA	0.463000													39	97					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49674630	49674630	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49674630C>T	ENST00000252826.5	+	7	939	c.813C>T	c.(811-813)atC>atT	p.I271I	TRPM4_ENST00000427978.2_Silent_p.I271I|TRPM4_ENST00000601347.1_3'UTR|TRPM4_ENST00000355712.5_5'UTR	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	271					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GAATTGACATCCCTGTCCTGC	0.562000													15	59					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160808825	160808825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160808825G>A	ENST00000368034.4	-	4	847	c.670C>T	c.(670-672)Ccg>Tcg	p.P224S	CD244_ENST00000368033.3_Missense_Mutation_p.P229S|CD244_ENST00000481677.1_5'UTR|CD244_ENST00000368032.2_Missense_Mutation_p.P224S|CD244_ENST00000322302.7_Missense_Mutation_p.P132S	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	229					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACCAAAAACGGCCAAAATCTG	0.522000													19	51					0	0	1	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187694567	187694567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:187694567G>A	ENST00000295131.2	-	8	1021	c.982C>T	c.(982-984)Ctc>Ttc	p.L328F		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	328					apoptosis		zinc ion binding	p.L328I(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ATCAGTTGGAGAGGCAGTGAT	0.393000													34	133					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121880150	121880150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121880150G>A	ENST00000377069.4	-	18	3293	c.2887C>T	c.(2887-2889)Ccg>Tcg	p.P963S	KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000377071.4_Missense_Mutation_p.P1032S|KDM2B_ENST00000542973.1_Missense_Mutation_p.P400S	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	1032					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CACTTGGGCGGGGACACGGAG	0.721000													3	11					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89854527	89854527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:89854527C>T	ENST00000287908.3	+	2	524	c.131C>T	c.(130-132)tCc>tTc	p.S44F	STEAP2_ENST00000402625.2_Missense_Mutation_p.S44F|STEAP2_ENST00000394622.2_Missense_Mutation_p.S44F|STEAP2_ENST00000394626.1_Missense_Mutation_p.S44F|STEAP2_ENST00000394632.1_Missense_Mutation_p.S44F|STEAP2_ENST00000394629.2_Missense_Mutation_p.S44F|STEAP2_ENST00000394621.2_Missense_Mutation_p.S44F	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	44					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					TTTGCCAAATCCTTGACCATT	0.388000													44	93					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35771777	35771777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35771777G>A	ENST00000440995.2	+	27	3853	c.3853G>A	c.(3853-3855)Gaa>Aaa	p.E1285K	SPEF2_ENST00000356031.3_Missense_Mutation_p.E1290K|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1290					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGACCCCAAAGAAAAATCTCC	0.398000													20	31					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73680076	73680076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73680076C>T	ENST00000264448.6	+	8	6530	c.6419C>T	c.(6418-6420)tCc>tTc	p.S2140F	ALMS1_ENST00000409009.1_Missense_Mutation_p.S2098F|ALMS1_ENST00000377715.1_Missense_Mutation_p.S2140F	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2140	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CTTCCTAGTTCCTTTTCACAT	0.413000													16	80					0	0	1	0	0
CD8B	926	broad.mit.edu	37	2	87085384	87085384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:87085384G>A	ENST00000390655.6	-	2	257	c.199C>T	c.(199-201)Cac>Tac	p.H67Y	CD8B_ENST00000431506.2_Intron|CD8B_ENST00000349455.3_Missense_Mutation_p.H67Y|CD8B_ENST00000393759.2_Missense_Mutation_p.H67Y|CD8B_ENST00000331469.2_Missense_Mutation_p.H67Y|CD8B_ENST00000393761.2_Missense_Mutation_p.H67Y	NM_004931.4	NP_004922.1	P10966	CD8B_HUMAN	CD8b molecule	67	Ig-like V-type.				immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	13						AGGAACTCGTGGTGACTGTCA	0.547000													7	89					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136597593	136597593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136597593G>A	ENST00000371872.4	-	3	719	c.462C>T	c.(460-462)ttC>ttT	p.F154F	SARDH_ENST00000371867.1_Silent_p.F65F|SARDH_ENST00000298628.5_Silent_p.F154F|SARDH_ENST00000422262.2_5'UTR|SARDH_ENST00000439388.1_Silent_p.F154F	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	154					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGGACGCGATGAAGAGGCCCC	0.672000													66	129					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20736568	20736568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20736568C>T	ENST00000427401.4	-	2	171	c.77G>A	c.(76-78)cGg>cAg	p.R26Q	ZNF737_ENST00000596797.1_Missense_Mutation_p.R26Q	NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	26					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						ATATAAATTCCGCTGTGCAGT	0.393000													19	225					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76450701	76450701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76450701G>A	ENST00000389840.5	-	64	10339	c.10215C>T	c.(10213-10215)ctC>ctT	p.L3405L	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.L3414L					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGTCGCTGGGGAGGCCCTGGT	0.642000													25	43					0	0	1	0	0
UBXN10	127733	broad.mit.edu	37	1	20517739	20517739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20517739G>A	ENST00000375099.3	+	2	769	c.685G>A	c.(685-687)Gaa>Aaa	p.E229K		NM_152376.3	NP_689589.1	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	229	UBX.									endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|skin(2)	14						TGCTGTGGCCGAACAGAAAAA	0.488000													38	76					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48866231	48866231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:48866231G>A	ENST00000314191.2	-	7	726	c.670C>T	c.(670-672)Ctg>Ttg	p.L224L	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Silent_p.L224L	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	224					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AACCCCTTCAGACATCCTGCC	0.388000								Non-homologous end-joining					6	20					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	141888927	141888927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141888927G>A	ENST00000306799.3	-	2	1238	c.585C>T	c.(583-585)atC>atT	p.I195I	RNF150_ENST00000515673.1_Silent_p.I195I|RNF150_ENST00000515057.1_5'UTR|RNF150_ENST00000507500.1_Silent_p.I195I|RNF150_ENST00000420921.2_Silent_p.I54I|RNF150_ENST00000379512.2_Silent_p.I54I	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150	195						integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					TCCGGGTTCCGATGGTGATGT	0.478000													55	162					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67664986	67664986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:67664986C>T	ENST00000335894.4	+	9	1357	c.1291C>T	c.(1291-1293)Cgc>Tgc	p.R431C	IQCH_ENST00000358767.3_Missense_Mutation_p.R258C|IQCH_ENST00000360277.4_Missense_Mutation_p.R183C|IQCH_ENST00000546225.1_Missense_Mutation_p.R179C	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	431										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		GGAGAATTTTCGCATTCGAGC	0.443000													52	174					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154667811	154667811	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:154667811G>A	ENST00000404039.1	+	20	2473		c.e20+1		DPP6_ENST00000427557.1_Splice_Site|DPP6_ENST00000377770.3_Splice_Site|DPP6_ENST00000332007.3_Splice_Site	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6						cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGGCCGTGCGGTGAGCACCCG	0.677000													4	18					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72993643	72993643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72993643G>A	ENST00000268489.5	-	2	1074	c.402C>T	c.(400-402)gtC>gtT	p.V134V	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	134					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CCGGCTGGTAGACGATCTCCC	0.711000													15	50					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356895	42356895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:42356895C>T	ENST00000554171.1	+	5	3499	c.1067C>T	c.(1066-1068)aCc>aTc	p.T356I	LRFN5_ENST00000554120.1_Missense_Mutation_p.T356I|LRFN5_ENST00000298119.4_Missense_Mutation_p.T356I			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	356	Ig-like.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GGTGCTTTTACCTGCATTGCT	0.393000										HNSCC(30;0.082)			43	91					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12649361	12649361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12649361C>T	ENST00000425538.1	+	9	1297	c.1097C>T	c.(1096-1098)cCa>cTa	p.P366L	MYOCD_ENST00000395988.1_Missense_Mutation_p.P270L|MYOCD_ENST00000343344.4_Missense_Mutation_p.P366L	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	366					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AAACCAGGCCCACTCCCACCT	0.408000													14	109					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158614085	158614085	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158614085C>T	ENST00000368148.3	-	30	4476	c.4296G>A	c.(4294-4296)ttG>ttA	p.L1432L	SPTA1_ENST00000368147.3_Silent_p.L1432L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1432					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTTCTTCATCAAAGCCTCCA	0.413000													31	64					0	0	1	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	521377	521377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:521377C>T	ENST00000262305.4	+	3	1279	c.891C>T	c.(889-891)ttC>ttT	p.F297F	RAB11FIP3_ENST00000457159.1_Silent_p.F297F	NM_014700.3	NP_055515.1	O75154	RFIP3_HUMAN	RAB11 family interacting protein 3 (class II)	297					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				TCGATGACTTCGTCACCTATG	0.602000													6	9					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149509362	149509362	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149509362G>A	ENST00000378016.2	+	0	9760							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGGAGCTGGGGGATGGGGTCC	0.701000													4	22					0	0	1	0	0
RP11-481J13.1	0	broad.mit.edu	37	2	56227922	56227922	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:56227922C>T	ENST00000606639.1	+	0	82				AC011306.2_ENST00000446139.1_lincRNA|MIR216B_ENST00000390186.2_RNA																							CAGAGATTTTCCAGTCTGCCA	0.363000													3	19					0	0	1	0	0
GADL1	339896	broad.mit.edu	37	3	30827849	30827849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:30827849C>T	ENST00000282538.5	-	13	1450	c.1300G>A	c.(1300-1302)Gaa>Aaa	p.E434K		NM_207359.2	NP_997242.2	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	434					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding			breast(2)|endometrium(3)|kidney(2)|lung(17)|upper_aerodigestive_tract(1)	25					Pyridoxal Phosphate(DB00114)	TCACTTACTTCCATCAGTAAC	0.299000													25	47					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47400205	47400205	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47400205G>A	ENST00000310638.4	-	7	848	c.817C>T	c.(817-819)Caa>Taa	p.Q273*	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Nonsense_Mutation_p.Q274*|CYP4A11_ENST00000371905.1_Nonsense_Mutation_p.Q273*|CYP4A11_ENST00000457840.2_Missense_Mutation_p.S117L	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	273					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	TTCTGTAGTTGAGCCTTCCTC	0.532000													31	93					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28667647	28667647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28667647C>T	ENST00000280904.6	-	6	1203	c.760G>A	c.(760-762)Gaa>Aaa	p.E254K	DSC2_ENST00000251081.6_Missense_Mutation_p.E254K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	254	Cadherin 2.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CTGCAATTTTCAAAAATTGTA	0.333000													39	78					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154072474	154072474	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154072474C>T	ENST00000368559.3	-	14	2036	c.1965_splice	c.e14+1	p.K655_splice	NUP210L_ENST00000271854.3_Splice_Site_p.K655_splice	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	655						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AATATCTTACCTTTAGGGGTT	0.408000													78	188					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679883	100679883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100679883C>T	ENST00000306151.4	+	3	5250	c.5186C>T	c.(5185-5187)tCa>tTa	p.S1729L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1729	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCCGTTCATCTCCTACA	0.507000													159	451					0	0	1	0	0
LYSMD1	388695	broad.mit.edu	37	1	151134286	151134286	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151134286G>A	ENST00000368908.5	-	2	1131	c.471C>T	c.(469-471)ttC>ttT	p.F157F	LYSMD1_ENST00000440902.2_Silent_p.F109F	NM_212551.4	NP_997716.1	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain containing 1	157					cell wall macromolecule catabolic process					endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCTTCTTAAGGAAATCAGAGG	0.507000													60	106					0	0	1	0	0
CER1	9350	broad.mit.edu	37	9	14722227	14722227	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14722227G>A	ENST00000380911.3	-	1	488	c.444C>T	c.(442-444)gtC>gtT	p.V148V		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	148					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		TGGGCAAGATGACCCCCTGAG	0.493000													9	79					0	0	1	0	0
SMIM8	57150	broad.mit.edu	37	6	88046769	88046769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88046769C>T	ENST00000392863.1	+	3	109	c.20C>T	c.(19-21)cCt>cTt	p.P7L	SMIM8_ENST00000229570.5_Missense_Mutation_p.P7L	NM_001042493.1	NP_001035958.1			small integral membrane protein 8																		GCACCTGAGCCTCCAACATTC	0.383000													16	66					0	0	1	0	0
EXO5	64789	broad.mit.edu	37	1	40980428	40980428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40980428C>T	ENST00000372703.1	+	2	1286	c.212C>T	c.(211-213)tCa>tTa	p.S71L	EXO5_ENST00000296380.4_Missense_Mutation_p.S71L|EXO5_ENST00000358527.2_Missense_Mutation_p.S71L|RP11-656D10.5_ENST00000453437.1_RNA					exonuclease 5																		GATATATTATCACCCATGGAG	0.428000													41	147					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49420128	49420128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49420128G>A	ENST00000374201.3	-	13	1782	c.1480C>T	c.(1480-1482)Cac>Tac	p.H494Y	FRMPD2_ENST00000407470.4_Missense_Mutation_p.H462Y|FRMPD2_ENST00000305531.3_Missense_Mutation_p.H469Y	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	494	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		TCTTCAACGTGAAAGTATGGC	0.517000													12	22					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085734	9085734	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9085734G>A	ENST00000397910.4	-	1	6284	c.6081C>T	c.(6079-6081)tcC>tcT	p.S2027S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2027	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AATATGGAGAGGATGTGCTGC	0.483000													17	71					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075287	9075287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9075287G>A	ENST00000397910.4	-	3	12362	c.12159C>T	c.(12157-12159)tcC>tcT	p.S4053S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4055	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCTCTTAGAGGAGGTAATTT	0.502000													42	144					0	0	1	0	0
CCDC64B	146439	broad.mit.edu	37	16	3080783	3080783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3080783C>T	ENST00000572449.1	-	4	591	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K	CCDC64B_ENST00000573514.1_5'UTR|CCDC64B_ENST00000389347.4_Missense_Mutation_p.E177K			A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	177										breast(1)|endometrium(2)|large_intestine(1)	4						GCGTCCAGTTCCCTCTGAAGT	0.642000													4	12					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188190	152188190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152188190C>T	ENST00000368801.2	-	3	5990	c.5915G>A	c.(5914-5916)gGg>gAg	p.G1972E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1972					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAAGACCACCCTGAGCCAGA	0.607000													69	1443					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958704	121958704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121958704G>A	ENST00000379692.4	-	4	948	c.422C>T	c.(421-423)tCc>tTc	p.S141F	NDNF_ENST00000506900.1_5'UTR	NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	141	Poly-Ser.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						ACCGGATGGGGAACTAGACGA	0.413000													40	95					0	0	1	0	0
UPF2	26019	broad.mit.edu	37	10	11978629	11978629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11978629G>A	ENST00000356352.2	-	18	3934	c.3461C>T	c.(3460-3462)cCc>cTc	p.P1154L	UPF2_ENST00000357604.5_Missense_Mutation_p.P1154L|UPF2_ENST00000397053.2_Missense_Mutation_p.P1154L			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	1154	Necessary for interaction with UPF1.|Sufficient for interaction with EIF4A1 and EIF1.|Sufficient for interaction with UPF1 C- terminus.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				TCCCAGTGGGGGCCCTTTCCT	0.463000													45	73					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84537277	84537277	+	Missense_Mutation	SNP	C	C	T	rs142898680	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84537277C>T	ENST00000262753.4	-	16	1841	c.1696G>A	c.(1696-1698)Gaa>Aaa	p.E566K	POF1B_ENST00000373145.3_Missense_Mutation_p.E566K	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	566							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						GGTATATATTCGTAGTCATCA	0.373000													17	17					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228509173	228509173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228509173G>A	ENST00000570156.2	+	66	17576	c.17502G>A	c.(17500-17502)gtG>gtA	p.V5834V	OBSCN_ENST00000366707.4_Silent_p.V2511V|OBSCN_ENST00000422127.1_Silent_p.V4877V|OBSCN_ENST00000284548.11_Silent_p.V4877V|OBSCN_ENST00000366709.4_Silent_p.V1996V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4877	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGCAGCTGTGAAGATCCAGG	0.597000													6	9					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90025464	90025464	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90025464C>T	ENST00000405460.2	+	50	10528	c.10432C>T	c.(10432-10434)Cag>Tag	p.Q3478*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3478					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGCAGGAGATCAGAATTCAAT	0.303000													5	21					0	0	1	0	0
KERA	11081	broad.mit.edu	37	12	91449884	91449884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91449884C>T	ENST00000266719.3	-	2	422	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	59	LRRNT.				response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						CCTCTATTTTCACAATATAAA	0.373000													31	79					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79240035	79240035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79240035G>A	ENST00000264895.6	+	18	2472	c.2032G>A	c.(2032-2034)Gaa>Aaa	p.E678K	FRAS1_ENST00000325942.6_Missense_Mutation_p.E678K|FRAS1_ENST00000264899.6_Missense_Mutation_p.E678K	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	678					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GAAGCCAGAGGAAGGACTGCA	0.527000													37	70					0	0	1	0	0
MAGEA11	4110	broad.mit.edu	37	X	148798216	148798216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:148798216G>A	ENST00000355220.5	+	5	1172	c.1070G>A	c.(1069-1071)aGg>aAg	p.R357K	MAGEA11_ENST00000333104.4_Missense_Mutation_p.R328K	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	357	MAGE.					cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GAGCCCAAGAGGCTCCTTACC	0.562000													102	78					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286023	48286023	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48286023T>A	ENST00000320048.1	+	1	611	c.611T>A	c.(610-612)aTc>aAc	p.I204N		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GGCGGCTCCATCTCCGTAGTC	0.552000													20	32					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565276	58565276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58565276C>T	ENST00000282326.1	+	6	1331	c.1084C>T	c.(1084-1086)Cca>Tca	p.P362S		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	362					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGAGTCCGTCCCACCCAGGGA	0.662000													16	29					0	0	1	0	0
SLC13A2	9058	broad.mit.edu	37	17	26821441	26821441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26821441C>T	ENST00000444914.3	+	9	1786	c.1366C>T	c.(1366-1368)Ctc>Ttc	p.L456F	SLC13A2_ENST00000545060.1_Missense_Mutation_p.L364F|SLC13A2_ENST00000537681.1_Missense_Mutation_p.L336F|SLC13A2_ENST00000314669.5_Missense_Mutation_p.L407F	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	407						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CCCTCTTGGCCTCCTCGACTG	0.567000											OREG0024276	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	49					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119934769	119934769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119934769G>A	ENST00000361035.4	+	7	1130	c.847G>A	c.(847-849)Ggg>Agg	p.G283R	HAO2_ENST00000325945.3_Missense_Mutation_p.G270R	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	270	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TGCTGTAAAGGGGAAAATTGA	0.488000													15	64					0	0	1	0	0
LGI3	203190	broad.mit.edu	37	8	22006104	22006104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22006104G>A	ENST00000306317.2	-	8	1505	c.1216C>T	c.(1216-1218)Cgc>Tgc	p.R406C	LGI3_ENST00000424267.2_Missense_Mutation_p.R382C	NM_139278.2	NP_644807.1	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	406					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	17				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		TTCTGGGTGCGACTCCACTGA	0.622000													10	28					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122287651	122287651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122287651C>T	ENST00000296161.4	+	3	904	c.715C>T	c.(715-717)Ccc>Tcc	p.P239S	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	239					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		TTTTGAAGTTCCCTTGCCTTA	0.398000													22	56					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25775392	25775392	+	Nonsense_Mutation	SNP	G	G	A	rs146140738	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:25775392G>A	ENST00000428257.1	-	8	1284	c.1177C>T	c.(1177-1179)Cga>Tga	p.R393*	NGLY1_ENST00000396649.3_Nonsense_Mutation_p.R411*|NGLY1_ENST00000417874.2_Nonsense_Mutation_p.R369*|NGLY1_ENST00000422724.2_3'UTR|NGLY1_ENST00000280700.5_Nonsense_Mutation_p.R411*|NGLY1_ENST00000467224.1_5'UTR	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	411					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding	p.R411*(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						ATAGTGTCTCGAAGTAATGCT	0.358000													21	88					0	0	1	0	0
AIM1L	55057	broad.mit.edu	37	1	26664512	26664512	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26664512C>T	ENST00000527815.1	-	7	925	c.876G>A	c.(874-876)ggG>ggA	p.G292G	AIM1L_ENST00000522993.1_5'UTR|AIM1L_ENST00000308182.5_Silent_p.G121G	NM_001039775.3	NP_001034864.2	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	121	Beta/gamma crystallin 'Greek key' 6.						sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|pancreas(1)|skin(2)	12		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CCCTGGGCTCCCCTGGCTTCT	0.577000													9	15					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87636987	87636987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:87636987G>A	ENST00000284262.2	+	1	477	c.235G>A	c.(235-237)Ggg>Agg	p.G79R		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	79	Gly-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		GGAGAGCAAGGGGAAGTGGGT	0.682000													9	7					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143034	55143034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55143034G>A	ENST00000396331.1	+	5	511	c.154G>A	c.(154-156)Ggc>Agc	p.G52S	LILRB1_ENST00000448689.1_Missense_Mutation_p.G52S|LILRB1_ENST00000434867.2_Missense_Mutation_p.G52S|LILRB1_ENST00000396332.4_Missense_Mutation_p.G52S|LILRB1_ENST00000427581.2_Missense_Mutation_p.G88S|LILRB1_ENST00000324602.7_Missense_Mutation_p.G52S|LILRB1_ENST00000418536.2_Missense_Mutation_p.G52S|LILRB1_ENST00000396317.1_Missense_Mutation_p.G52S|LILRB1_ENST00000396321.2_Missense_Mutation_p.G52S|LILRB1_ENST00000396315.1_Missense_Mutation_p.G52S|LILRB1_ENST00000396327.3_Missense_Mutation_p.G52S	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	52	Ig-like C2-type 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GTGTCAGGGGGGCCAGGAGAC	0.572000										HNSCC(37;0.09)			50	101					0	0	1	0	0
ICAM2	3384	broad.mit.edu	37	17	62082713	62082713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62082713C>T	ENST00000412356.1	-	4	436	c.82G>A	c.(82-84)Gag>Aag	p.E28K	ICAM2_ENST00000418105.1_Missense_Mutation_p.E28K|ICAM2_ENST00000578892.1_Missense_Mutation_p.E28K|ICAM2_ENST00000578379.1_5'UTR|ICAM2_ENST00000581417.1_5'UTR|ICAM2_ENST00000449662.2_Missense_Mutation_p.E28K|ICAM2_ENST00000579788.1_Missense_Mutation_p.E28K|ICAM2_ENST00000579687.1_Missense_Mutation_p.E28K	NM_001099786.1	NP_001093256.1	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2	28					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			large_intestine(1)|lung(2)|ovary(1)|skin(2)	6						ACGTGTACCTCGAATACCTTC	0.582000													6	47					0	0	1	0	0
BMP7	655	broad.mit.edu	37	20	55803379	55803379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:55803379C>T	ENST00000395863.3	-	2	1022	c.517G>A	c.(517-519)Gaa>Aaa	p.E173K	BMP7_ENST00000450594.2_Missense_Mutation_p.E173K|BMP7_ENST00000395864.3_Missense_Mutation_p.E173K	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7	173					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity	p.E173K(1)		endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			ATCCGGAATTCGGCTGCCGTG	0.537000													70	136					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51555737	51555737	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:51555737C>T	ENST00000358559.2	+	2	97	c.10C>T	c.(10-12)Ctc>Ttc	p.L4F	MSMB_ENST00000474170.1_3'UTR|MSMB_ENST00000298239.6_Missense_Mutation_p.L4F	NM_002443.3	NP_002434.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	4						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						ACAGAATGTTCTCCTGGGCAG	0.458000													17	40					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914895	46914895	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46914895C>T	ENST00000307522.3	-	1	1946	c.1173G>A	c.(1171-1173)caG>caA	p.Q391Q		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	391						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CCTCCGCCCTCTGATTATCTG	0.587000													39	190					0	0	1	0	0
DAND5	199699	broad.mit.edu	37	19	13084385	13084385	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13084385C>T	ENST00000317060.2	+	2	686	c.507C>T	c.(505-507)tcC>tcT	p.S169S	DAND5_ENST00000585548.1_3'UTR	NM_152654.2	NP_689867.1	Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	169	CTCK.					extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			GCTCAGCCTCCCGTCGACGGG	0.612000													37	84					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154139092	154139092	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:154139092T>A	ENST00000389740.2	-	3	1458	c.1359A>T	c.(1357-1359)aaA>aaT	p.K453N		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	453						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGATTTCTACTTTTATAGCAT	0.398000													53	203					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108070663	108070663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108070663G>A	ENST00000467562.1	+	4	247	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	HHLA2_ENST00000467761.1_Start_Codon_SNP_p.M1I|HHLA2_ENST00000357759.5_Start_Codon_SNP_p.M1I|HHLA2_ENST00000489514.2_Start_Codon_SNP_p.M1I|HHLA2_ENST00000491820.1_Start_Codon_SNP_p.M1I			Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	0						integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						CACAAGACATGAAGGCACAGA	0.358000													17	23					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19369408	19369408	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19369408C>T	ENST00000291481.7	-	4	804	c.741G>A	c.(739-741)ggG>ggA	p.G247G	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	247	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			TGCGCAGGCCCCCGTTGGCAT	0.697000													5	51					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42635205	42635205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42635205G>A	ENST00000358131.5	+	3	419	c.211G>A	c.(211-213)Gag>Aag	p.E71K	TOX2_ENST00000341197.3_Missense_Mutation_p.E62K|TOX2_ENST00000423191.1_Missense_Mutation_p.E20K|TOX2_ENST00000372999.1_Missense_Mutation_p.E20K	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CGGCCAGAGCGAGAACAACGA	0.547000													39	102					0	0	1	0	0
RFPL1S	10740	broad.mit.edu	37	22	29833658	29833658	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29833658C>T	ENST00000461286.2	-	0	4718					NR_002727.2																						GTGCCCCTTCCGCACAAGACC	0.522000													6	26					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97426937	97426937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97426937C>T	ENST00000377075.2	+	1	299	c.201C>T	c.(199-201)ttC>ttT	p.F67F		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	67					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GCATCATCTTCGTGTCCGAGG	0.647000													16	47					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5436228	5436228	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:5436228C>T	ENST00000345221.3	-	11	3764	c.3210G>A	c.(3208-3210)acG>acA	p.T1070T	NLRP1_ENST00000262467.5_Silent_p.T1074T|NLRP1_ENST00000577119.1_Silent_p.T1040T|NLRP1_ENST00000572272.1_Silent_p.T1070T|NLRP1_ENST00000269280.4_Silent_p.T1070T|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000354411.3_Silent_p.T1040T	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	1070					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				CCAAAGGCTTCGTATGCAGGT	0.577000													23	34					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28722112	28722112	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28722112C>T	ENST00000257197.3	-	9	1371	c.1110G>A	c.(1108-1110)gtG>gtA	p.V370V	DSC1_ENST00000257198.5_Silent_p.V370V|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	370	Cadherin 3.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GTAAAATCTCCACGTCAATTC	0.333000													19	82					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129070703	129070703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:129070703G>A	ENST00000274487.4	+	22	3518	c.3373G>A	c.(3373-3375)Gaa>Aaa	p.E1125K	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1125	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ACATGGAAATGAATGTTTTTC	0.418000													27	76					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31323334	31323334	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:31323334G>A	ENST00000542188.1	-	22	3343	c.3030C>T	c.(3028-3030)gtC>gtT	p.V1010V	TRPM1_ENST00000397795.2_Silent_p.V971V|RP11-348B17.1_ENST00000558755.1_RNA|RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000256552.6_Silent_p.V993V	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	971					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CCAGCATGATGACCACAAAGT	0.493000													34	78					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463744	25463744	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25463744G>A	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						GCATGTGCGGGAAGGGGGGTG	0.542000													110	216					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20582410	20582410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20582410C>T	ENST00000202677.6	-	16	2261	c.2119G>A	c.(2119-2121)Gaa>Aaa	p.E707K	RALGAPA2_ENST00000495793.1_5'UTR	NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	707					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						CGCATCGGTTCGGTCACATCT	0.478000													17	47					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91234063	91234063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:91234063G>A	ENST00000509176.1	+	3	1662	c.1374G>A	c.(1372-1374)agG>agA	p.R458R	CCSER1_ENST00000432775.2_Silent_p.R458R|CCSER1_ENST00000333691.8_Silent_p.R458R	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		TTATAGAGAGGAGACTGCGAT	0.348000													3	7					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896748	175896748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175896748C>T	ENST00000359240.3	+	5	742	c.72C>T	c.(70-72)caC>caT	p.H24H	ADAM29_ENST00000445694.1_Silent_p.H24H|ADAM29_ENST00000404450.4_Silent_p.H24H|ADAM29_ENST00000514159.1_Silent_p.H24H	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	24					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AGGATGAGCACCCCCAATATC	0.512000													19	56					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880658	142880658	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142880658C>T	ENST00000446620.1	+	1	147	c.147C>T	c.(145-147)atC>atT	p.I49I		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	49					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					TCATTGGTATCATTGCAAATG	0.408000													31	45					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71418430	71418430	+	Missense_Mutation	SNP	C	C	T	rs140473608	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:71418430C>T	ENST00000392650.3	-	15	2041	c.2041G>A	c.(2041-2043)Gag>Aag	p.E681K	SDK2_ENST00000388726.3_Missense_Mutation_p.E681K	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	681	Fibronectin type-III 1.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CCTCACCTCTCGGTGTCTTTG	0.607000													23	48					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79434665	79434665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:79434665G>A	ENST00000554719.1	+	11	2490	c.1999G>A	c.(1999-2001)Gga>Aga	p.G667R	NRXN3_ENST00000335750.5_Missense_Mutation_p.G667R	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TCATCGGAGCGGACAGATCGA	0.522000													23	52					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49407996	49407996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49407996C>T	ENST00000299191.3	+	1	263	c.146C>T	c.(145-147)cCc>cTc	p.P49L		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	49										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						AAACAAGCTCCCGAGGTGGGT	0.507000													18	62					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3784232	3784232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3784232C>T	ENST00000310132.6	-	5	650	c.252G>A	c.(250-252)aaG>aaA	p.K84K	MATK_ENST00000585778.1_Silent_p.K84K|MATK_ENST00000395045.2_Silent_p.K85K|MATK_ENST00000395040.2_Silent_p.K43K	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	84	SH3.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTACCAGCTCTTGTTCTGCC	0.697000													15	49					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10279981	10279981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:10279981G>A	ENST00000254976.2	+	7	684	c.473G>A	c.(472-474)gGg>gAg	p.G158E	SNAP25-AS1_ENST00000453544.1_RNA|SNAP25_ENST00000495883.1_3'UTR|SNAP25_ENST00000304886.2_Missense_Mutation_p.G158E|SNAP25-AS1_ENST00000421143.2_RNA	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	158	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	GGCATCATCGGGAACCTCCGT	0.502000													38	141					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43500853	43500853	+	Missense_Mutation	SNP	C	C	T	rs143974871	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43500853C>T	ENST00000300215.3	-	7	1500	c.1043G>A	c.(1042-1044)gGc>gAc	p.G348D	EPB42_ENST00000441366.2_Missense_Mutation_p.G318D|EPB42_ENST00000540029.1_Missense_Mutation_p.G240D			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	318					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GCCTCTCTGGCCTTCTCCGTT	0.587000													30	332					0	0	1	0	0
LMBR1	64327	broad.mit.edu	37	7	156619309	156619309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:156619309G>A	ENST00000353442.4	-	4	545	c.309C>T	c.(307-309)tcC>tcT	p.S103S	LMBR1_ENST00000540390.1_Silent_p.S82S|LMBR1_ENST00000354505.4_Silent_p.S103S	NM_022458.3	NP_071903.2	Q8WVP7	LMBR1_HUMAN	limb development membrane protein 1	103						integral to membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	18	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		CATGAATCAGGGAGCCATTTA	0.323000													8	8					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11964828	11964828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11964828C>T	ENST00000256720.2	+	20	2677	c.2584C>T	c.(2584-2586)Ccc>Tcc	p.P862S	LPIN1_ENST00000449576.2_Missense_Mutation_p.P947S|LPIN1_ENST00000396099.1_Missense_Mutation_p.P904S|LPIN1_ENST00000425416.2_Missense_Mutation_p.P868S|LPIN1_ENST00000396097.1_Missense_Mutation_p.P592S|LPIN1_ENST00000404113.2_Missense_Mutation_p.P363S	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	862					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		TTCAGACTTTCCCTGTTCGGA	0.473000													32	62					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19947154	19947154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:19947154C>T	ENST00000295824.9	-	6	1537	c.1376G>A	c.(1375-1377)cGa>cAa	p.R459Q	EFHB_ENST00000344838.4_Missense_Mutation_p.R329Q|EFHB_ENST00000498089.1_5'UTR	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	459					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						TGCCATGGCTCGTCCATCATT	0.383000													33	87					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113703756	113703756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113703756G>A	ENST00000374431.3	-	4	1121	c.738C>T	c.(736-738)ccC>ccT	p.P246P	LPAR1_ENST00000538760.1_Silent_p.P247P|LPAR1_ENST00000541779.1_Silent_p.P247P|LPAR1_ENST00000374430.2_Silent_p.P246P|LPAR1_ENST00000358883.4_Silent_p.P246P	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	246					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						GATTCCGCCGGGGTCCAGAAC	0.453000													23	55					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54955914	54955914	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54955914C>T	ENST00000173898.7	+	12	2869	c.2757C>T	c.(2755-2757)ttC>ttT	p.F919F	TRO_ENST00000375022.4_Intron|TRO_ENST00000375041.2_Silent_p.F522F|TRO_ENST00000399736.1_Intron|TRO_ENST00000420798.2_Silent_p.F450F|TRO_ENST00000319167.8_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	919	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GTATCTGCTTCGGTGGCTCTC	0.552000													16	22					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575565	136575565	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136575565C>T	ENST00000264162.2	-	6	1063	c.1053G>A	c.(1051-1053)acG>acA	p.T351T		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	351	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGAGGAGTCCGTGGTCTCGT	0.542000													30	77					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	101031041	101031041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101031041G>A	ENST00000284382.4	-	5	692	c.269C>T	c.(268-270)tCc>tTc	p.S90F	CERS3_ENST00000394113.1_Missense_Mutation_p.S90F|CERS3_ENST00000560944.1_Intron|CERS3_ENST00000538112.2_Missense_Mutation_p.S90F	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	90						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										TTGCCTTGTGGAATGTTTGAA	0.338000													13	65					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48541212	48541212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48541212C>T	ENST00000427954.2	+	10	1198	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	ACSF2_ENST00000300441.4_Silent_p.F360F|ACSF2_ENST00000541920.1_Silent_p.F200F|ACSF2_ENST00000502667.1_Silent_p.F347F|ACSF2_ENST00000504392.1_Silent_p.F317F			Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	360					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CCACGATGTTCGTGGACATTC	0.577000													46	97					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183721410	183721410	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183721410G>A	ENST00000511685.1	+	28	8129	c.8006G>A	c.(8005-8007)gGg>gAg	p.G2669E	TENM3_ENST00000406950.2_Missense_Mutation_p.G2669E					teneurin transmembrane protein 3																		GGCTACGACGGGTACTACGTA	0.692000													3	15					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17474704	17474704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17474704C>T	ENST00000302539.4	-	7	1263	c.1138G>A	c.(1138-1140)Gcc>Acc	p.A380T	ABCC8_ENST00000389817.3_Missense_Mutation_p.A380T	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	380	ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GTTTCAATGGCCACATAGTAG	0.418000													27	98					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58551861	58551861	+	Silent	SNP	C	C	T	rs147151087		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58551861C>T	ENST00000282326.1	+	4	661	c.414C>T	c.(412-414)ttC>ttT	p.F138F		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	138					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		ACTGGAGTTTCGGTGAGGAGG	0.612000													10	177					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671680	31671680	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31671680G>A	ENST00000375483.3	+	3	677	c.677_splice	c.e3+1	p.G226_splice		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	226	Gly-rich.					cytoplasm|extracellular region	lipid binding										GGCATCACGGGGTAAGGAGGG	0.622000													5	33					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122787290	122787290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122787290G>A	ENST00000194130.2	-	7	774	c.735C>T	c.(733-735)gcC>gcT	p.A245A	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	245						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TAGAAGAGTAGGCAATGCACA	0.413000													9	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065468	9065468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9065468G>A	ENST00000397910.4	-	3	22181	c.21978C>T	c.(21976-21978)atC>atT	p.I7326I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7328	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTGGGTCTTGATGGTCATTT	0.443000													5	59					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60785320	60785320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60785320C>T	ENST00000313421.7	+	11	1858	c.1672C>T	c.(1672-1674)Ccg>Tcg	p.P558S	CD6_ENST00000344028.5_Missense_Mutation_p.P526S|CD6_ENST00000452451.2_Missense_Mutation_p.P517S|CD6_ENST00000352009.5_Missense_Mutation_p.P526S|CD6_ENST00000346437.4_Missense_Mutation_p.P485S	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	558					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						TCAGTATCACCCGAGGAGCAA	0.552000													35	84					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155505308	155505308	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155505308G>A	ENST00000302053.3	-	6	2647	c.2569C>T	c.(2569-2571)Cgc>Tgc	p.R857C		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	857	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding	p.R857C(1)		NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ATTTTCATGCGAACAGCCCTG	0.473000													13	133					0	0	1	0	0
PLGLA	285189	broad.mit.edu	37	2	107004058	107004058	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107004058G>A	ENST00000484422.1	+	0	147																											TGTGATAATGGCTGAAAACAA	0.348000													54	190					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33588192	33588192	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33588192G>A	ENST00000262873.7	+	37	5096	c.5004G>A	c.(5002-5004)gaG>gaA	p.E1668E		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1626						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGAAGATGGAGGGTGACCTCA	0.657000													43	95					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114185980	114185980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:114185980G>A	ENST00000297405.5	-	4	924	c.680C>T	c.(679-681)tCg>tTg	p.S227L	CSMD3_ENST00000455883.2_Missense_Mutation_p.S227L|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Missense_Mutation_p.S187L|CSMD3_ENST00000352409.3_Missense_Mutation_p.S227L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	227	Sushi 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAAATCCCACGAAGCTGTATT	0.433000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	132					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848392	54848392	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54848392G>A	ENST00000291759.4	-	6	1031	c.975C>T	c.(973-975)tcC>tcT	p.S325S	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	325	Ig-like C2-type 4.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GCACTGAGAGGGAGGGTCTGT	0.607000													17	54					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774727	140774727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140774727G>A	ENST00000398604.2	+	1	2347	c.2347G>A	c.(2347-2349)Gag>Aag	p.E783K	PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCAGTCAGGAGGGCTGTGA	0.473000													27	120					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3638758	3638758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3638758G>A	ENST00000378295.4	+	5	758	c.603G>A	c.(601-603)agG>agA	p.R201R	TP73_ENST00000346387.4_Silent_p.R201R|TP73_ENST00000604074.1_Silent_p.R201R|TP73_ENST00000378280.1_Silent_p.R152R|TP73_ENST00000378290.4_Silent_p.R130R|TP73_ENST00000378285.1_Silent_p.R152R|TP73_ENST00000603362.1_Silent_p.R201R|TP73_ENST00000378288.4_Silent_p.R152R|TP73_ENST00000357733.3_Silent_p.R201R|TP73_ENST00000604479.1_Silent_p.R201R|TP73_ENST00000354437.4_Silent_p.R201R	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	201	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		AGCTCGGGAGGGACTTCAACG	0.662000													13	29					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73676650	73676650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73676650C>T	ENST00000264448.6	+	8	3104	c.2993C>T	c.(2992-2994)cCt>cTt	p.P998L	ALMS1_ENST00000409009.1_Missense_Mutation_p.P956L|ALMS1_ENST00000377715.1_Missense_Mutation_p.P998L	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	998	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CCAACAGTACCTTCAGGTTCC	0.453000													50	120					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53012211	53012211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53012211C>T	ENST00000305748.3	-	1	132	c.98G>A	c.(97-99)cGa>cAa	p.R33Q		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	33	Gly-rich.|Head.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCCCCTGCTCGGTAGGAGGA	0.637000													39	111					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67221470	67221470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67221470C>T	ENST00000314586.6	-	5	938	c.698G>A	c.(697-699)cGa>cAa	p.R233Q	EXOC3L1_ENST00000562887.1_Intron	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	233	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						GGGGGTTGTTCGTCCAGTCTC	0.687000													10	53					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12958036	12958036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:12958036G>A	ENST00000276297.4	-	9	2219	c.1810C>T	c.(1810-1812)Ccc>Tcc	p.P604S	DLC1_ENST00000512044.2_Missense_Mutation_p.P201S|DLC1_ENST00000520226.1_Missense_Mutation_p.P93S|DLC1_ENST00000358919.2_Missense_Mutation_p.P167S	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	604					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCGTGGCTGGGGAGGCTGCCA	0.672000													10	86					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058002	79058002	+	Silent	SNP	C	C	T	rs143941580		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79058002C>T	ENST00000388820.4	-	19	4461	c.4251G>A	c.(4249-4251)gcG>gcA	p.A1417A		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1417	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.A1417A(1)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						TCCAGTTTCCCGCTTGCCAGC	0.642000													40	94					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179408973	179408973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179408973C>T	ENST00000589042.1	-	345	96207	c.95983G>A	c.(95983-95985)Gaa>Aaa	p.E31995K	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E29427K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E30354K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E23122K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E23055K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E22930K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30354	Ig-like 142.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCGCTGTATTCGCTCATACCC	0.408000													27	52					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64649419	64649419	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:64649419C>T	ENST00000587624.1	+	0	1200																											CAAGAGGATCCTTCGCAGCAG	0.502000													23	71					0	0	1	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79629625	79629625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:79629625C>T	ENST00000263849.4	+	9	977	c.875C>T	c.(874-876)tCa>tTa	p.S292L		NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	292																	GAAGGACATTCACCTGGAAAC	0.383000													47	123					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38186485	38186485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38186485C>T	ENST00000373048.4	-	12	2177	c.2178G>A	c.(2176-2178)atG>atA	p.M726I	EPHA10_ENST00000540011.1_3'UTR|EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000330210.7_Missense_Mutation_p.M221I|EPHA10_ENST00000427468.2_Missense_Mutation_p.M726I	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	726	Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCCATGGCTCATGTACTCGG	0.572000													30	49					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25326463	25326463	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25326463C>T	ENST00000546682.1	+	0	71				SNORD116-15_ENST00000384445.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TATATACATTCCTTGGAAAGC	0.458000													76	197					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5892017	5892017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:5892017C>T	ENST00000581347.1	-	3	691	c.46G>A	c.(46-48)Gat>Aat	p.D16N	TMEM200C_ENST00000383490.2_Missense_Mutation_p.D16N|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	16						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						CGGAGTGGATCCTGCTTTCTG	0.612000													10	28					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33696629	33696629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33696629G>A	ENST00000253193.7	+	5	1155	c.953G>A	c.(952-954)gGg>gAg	p.G318E		NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	318	CUB 2.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					GGCGAGCGCGGGGACCGCCTG	0.711000													3	23					0	0	1	0	0
TREML1	340205	broad.mit.edu	37	6	41121769	41121769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41121769G>A	ENST00000373127.4	-	2	151	c.103C>T	c.(103-105)Ctg>Ttg	p.L35L	TREML1_ENST00000437044.2_Intron|TREML1_ENST00000426005.2_Silent_p.L35L	NM_001271807.1	NP_001258736.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	35	Ig-like V-type.				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					CACTGCACCAGAATGGAGCTT	0.617000													11	31					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36170360	36170360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:36170360G>A	ENST00000335119.2	+	1	972	c.861G>A	c.(859-861)caG>caA	p.Q287Q		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	287					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			TCGGTGGCCAGAAGGCCCACG	0.572000													10	74					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	652761	652761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:652761G>A	ENST00000255622.6	+	11	1465	c.1422G>A	c.(1420-1422)ggG>ggA	p.G474G	PDE6B_ENST00000429163.2_Silent_p.G195G|PDE6B_ENST00000496514.1_Silent_p.G474G	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	474					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						CGCGCCTGGGGAAGGAGCCTG	0.622000													12	56					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	91996156	91996156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91996156G>A	ENST00000450295.1	-	14	2328	c.1552C>T	c.(1552-1554)Ccc>Tcc	p.P518S	SEMA4D_ENST00000455551.2_Missense_Mutation_p.P518S|SEMA4D_ENST00000343780.4_Missense_Mutation_p.P518S|SEMA4D_ENST00000438547.2_Missense_Mutation_p.P518S|SEMA4D_ENST00000420987.1_Missense_Mutation_p.P518S|SEMA4D_ENST00000339861.4_Missense_Mutation_p.P518S|SEMA4D_ENST00000356444.2_Missense_Mutation_p.P518S|SEMA4D_ENST00000422704.2_Missense_Mutation_p.P518S			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	518	PSI.				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						GCGCAGTAGGGGTCCCGCGCC	0.687000													10	13					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55136093	55136093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55136093C>T	ENST00000314706.3	+	1	734	c.734C>T	c.(733-735)tCc>tTc	p.S245F		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						ATCCTGCTTTCCTATGGGGTC	0.428000													36	88					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88690576	88690576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88690576G>A	ENST00000394480.1	-	6	775	c.454C>T	c.(454-456)Ctt>Ttt	p.L152F	NTRK3_ENST00000542733.2_Missense_Mutation_p.L54F|NTRK3_ENST00000355254.2_Missense_Mutation_p.L152F|NTRK3_ENST00000317501.3_Missense_Mutation_p.L152F|NTRK3_ENST00000357724.2_Missense_Mutation_p.L152F|NTRK3_ENST00000540489.2_Missense_Mutation_p.L152F|NTRK3_ENST00000558676.1_Missense_Mutation_p.L152F|NTRK3_ENST00000360948.2_Missense_Mutation_p.L152F|NTRK3_ENST00000557856.1_Missense_Mutation_p.L152F	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	152					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.L152I(1)	ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AATTCCCGAAGACTCAGCGTC	0.478000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			19	61					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686806	68686806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:68686806G>A	ENST00000361320.4	+	2	710	c.132G>A	c.(130-132)atG>atA	p.M44I	CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	44	LRRNT.					integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						AAGGCAAAATGGTATATTGTG	0.443000													24	53					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114377567	114377567	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114377567C>T	ENST00000359785.5	-	14	1994	c.1859G>A	c.(1858-1860)tGg>tAg	p.W620*	PTPN22_ENST00000528414.1_Nonsense_Mutation_p.W565*|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000420377.2_Nonsense_Mutation_p.W620*|PTPN22_ENST00000525799.1_Nonsense_Mutation_p.W493*|PTPN22_ENST00000538253.1_Nonsense_Mutation_p.W376*	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	620			R -> W (confers susceptibility to systemic lupus erythematosus and type 1 diabetes mellitus; affects CSK kinase binding; dbSNP:rs2476601).		negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCAGGTGTCCATACAGGAAG	0.383000													13	193					0	0	1	0	0
OR1D2	4991	broad.mit.edu	37	17	2995949	2995949	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:2995949G>A	ENST00000331459.1	-	1	341	c.342C>T	c.(340-342)atC>atT	p.I114I		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	114					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						TCACAGCCAGGATGAGGTTGT	0.542000													52	65					0	0	1	0	0
MIR100	406892	broad.mit.edu	37	11	122023001	122023001	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:122023001G>A	ENST00000385259.1	-	0	15					NR_029515.1																						CGGATCTACGGGTTTGTGGCA	0.413000													21	48					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40363885	40363885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40363885C>T	ENST00000221347.6	-	31	14764	c.14757G>A	c.(14755-14757)gtG>gtA	p.V4919V		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4919	VWFD 12.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAGCTAGGCTCACAACCTGGC	0.607000													17	49					0	0	1	0	0
RHBDF2	79651	broad.mit.edu	37	17	74475819	74475819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74475819G>A	ENST00000591885.1	-	4	818	c.268C>T	c.(268-270)Cgc>Tgc	p.R90C	RHBDF2_ENST00000592378.1_Intron|RHBDF2_ENST00000389760.4_Missense_Mutation_p.R90C|RHBDF2_ENST00000313080.4_Missense_Mutation_p.R119C			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	119					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity	p.R119C(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						GCTCACTTGCGGATGCTCTGG	0.662000													6	21					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13910382	13910382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:13910382C>T	ENST00000294489.6	+	1	423	c.82C>T	c.(82-84)Ctc>Ttc	p.L28F	PDPN_ENST00000376057.4_Missense_Mutation_p.L28F			Q86YL7	PDPN_HUMAN	podoplanin	0					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		GGCACCCTCCCTCTCCGGGGC	0.647000													22	43					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047558	42047558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42047558G>A	ENST00000372584.1	-	3	3925	c.2911C>T	c.(2911-2913)Ctg>Ttg	p.L971L	HIVEP3_ENST00000429157.2_Silent_p.L971L|HIVEP3_ENST00000372583.1_Silent_p.L971L|HIVEP3_ENST00000247584.5_Silent_p.L971L	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	971	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGGTGCCCAGGGGTTTGGGG	0.617000													16	89					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166167071	166167071	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166167071C>T	ENST00000357398.3	+	7	1226	c.936C>T	c.(934-936)agC>agT	p.S312S	SCN2A_ENST00000375437.2_Silent_p.S312S|SCN2A_ENST00000375427.2_Silent_p.S312S|SCN2A_ENST00000283256.6_Silent_p.S312S			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	312					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GGACAGTGAGCATATTTAACT	0.289000													18	47					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491647	100491647	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100491647C>T	ENST00000302913.4	-	2	345	c.207G>A	c.(205-207)gcG>gcA	p.A69A	ACHE_ENST00000428317.1_Silent_p.A69A|ACHE_ENST00000412389.1_Silent_p.A69A|ACHE_ENST00000411582.1_Silent_p.A69A|ACHE_ENST00000241069.5_Silent_p.A69A|ACHE_ENST00000419336.2_Silent_p.A69A	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	69					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	TGGGTGGCTCCGCAAAGGGGA	0.652000													7	24					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43670062	43670062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43670062C>T	ENST00000564079.1	+	5	642	c.402C>T	c.(400-402)ccC>ccT	p.P134P	TUBGCP4_ENST00000260383.7_Silent_p.P134P|TUBGCP4_ENST00000399460.3_5'UTR	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	134					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		TTCTTTTTCCCTCTGTGATGG	0.323000													29	103					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74332987	74332987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:74332987G>A	ENST00000377044.4	-	13	2815	c.2276C>T	c.(2275-2277)cCt>cTt	p.P759L	TMEM2_ENST00000377066.5_Missense_Mutation_p.P696L	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	759						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		ATCCTGATGAGGTCGAAATCT	0.348000													13	103					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186106	127186106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:127186106C>T	ENST00000371124.3	-	1	276	c.80G>A	c.(79-81)gGa>gAa	p.G27E		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	27						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						TCCAATCTCTCCAGACAGGCC	0.443000													9	42					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54822693	54822693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54822693G>A	ENST00000301219.3	-	5	822	c.703C>T	c.(703-705)Ccg>Tcg	p.P235S	LILRA5_ENST00000346508.3_Missense_Mutation_p.P223S|AC008984.2_ENST00000507363.1_RNA|LILRA5_ENST00000446712.3_Missense_Mutation_p.P223S|LILRA5_ENST00000432233.3_Missense_Mutation_p.P235S	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	235					innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCTGAGACCGGAATCTCCAGG	0.567000													36	80					0	0	1	0	0
SHD	56961	broad.mit.edu	37	19	4284825	4284825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4284825G>A	ENST00000543264.2	+	4	2103	c.640G>A	c.(640-642)Gag>Aag	p.E214K	SHD_ENST00000599689.1_Missense_Mutation_p.E214K|SHD_ENST00000600475.1_3'UTR	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	214										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAGCCAAGGAGCTCCGGAG	0.617000													14	49					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57088760	57088760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57088760C>T	ENST00000330619.8	+	6	1649	c.963C>T	c.(961-963)ttC>ttT	p.F321F	ZNF470_ENST00000391709.3_Silent_p.F321F|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ATAAAGCATTCAGCCAGCTTG	0.448000													27	51					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86518066	86518066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:86518066G>A	ENST00000297814.2	-	4	1510	c.1367C>T	c.(1366-1368)tCa>tTa	p.S456L	KIF27_ENST00000334204.2_Missense_Mutation_p.S456L|KIF27_ENST00000413982.1_Missense_Mutation_p.S456L	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	456					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TCCTCGAAATGAGGTGAGGAC	0.463000													19	65					0	0	1	0	0
GPR55	9290	broad.mit.edu	37	2	231775112	231775112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231775112C>T	ENST00000392040.1	-	2	758	c.566G>A	c.(565-567)gGc>gAc	p.G189D	GPR55_ENST00000392039.2_Missense_Mutation_p.G189D	NM_005683.3	NP_005674.2	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	189					activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			endometrium(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		AAGGAGGAAGCCAAACACCTC	0.547000													31	121					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18674337	18674337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18674337C>T	ENST00000406451.3	+	8	1025	c.875C>T	c.(874-876)tCg>tTg	p.S292L	HDAC9_ENST00000401921.1_Missense_Mutation_p.S251L|HDAC9_ENST00000406072.1_Missense_Mutation_p.S279L|HDAC9_ENST00000417496.2_Missense_Mutation_p.S290L|HDAC9_ENST00000428307.2_Missense_Mutation_p.S248L|HDAC9_ENST00000456174.2_Missense_Mutation_p.S264L|HDAC9_ENST00000524023.1_Missense_Mutation_p.S215L|HDAC9_ENST00000441542.2_Missense_Mutation_p.S295L|HDAC9_ENST00000405010.3_Missense_Mutation_p.S292L|HDAC9_ENST00000432645.2_Missense_Mutation_p.S292L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	292	Interaction with MAPK10 (By similarity).				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	AATGAGACTTCGGTTTTGCCC	0.403000													5	10					0	0	1	0	0
MCMDC2	157777	broad.mit.edu	37	8	67803171	67803171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:67803171C>T	ENST00000422365.2	+	10	1316	c.1145C>T	c.(1144-1146)aCt>aTt	p.T382I	MCMDC2_ENST00000313616.5_Missense_Mutation_p.T382I|MCMDC2_ENST00000396592.3_Missense_Mutation_p.T382I|MCMDC2_ENST00000541540.1_Missense_Mutation_p.T319I	NM_173518.4	NP_775789.3	Q4G0Z9	CH045_HUMAN	minichromosome maintenance domain containing 2	382					DNA replication		ATP binding|DNA binding			endometrium(2)|kidney(2)|lung(5)	9						ATTTTTCCCACTCTATCCAGG	0.408000													34	108					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65234028	65234028	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65234028C>T	ENST00000389722.3	-	30	6315	c.6262G>A	c.(6262-6264)Gag>Aag	p.E2088K	SPTB_ENST00000556626.1_Missense_Mutation_p.E2088K|SPTB_ENST00000542895.1_Missense_Mutation_p.E2088K|SPTB_ENST00000389721.5_Missense_Mutation_p.E2088K|SPTB_ENST00000389720.3_Intron	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	2088					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CACCCAGTCTCCTCTGCGGGT	0.577000													59	246					0	0	1	0	0
GOT2	2806	broad.mit.edu	37	16	58757655	58757655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58757655G>A	ENST00000245206.5	-	2	369	c.241C>T	c.(241-243)Cgc>Tgc	p.R81C	GOT2_ENST00000434819.2_Missense_Mutation_p.R81C|GOT2_ENST00000564400.1_5'UTR	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	81					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTCACCTTGCGGACGCTAGGC	0.498000													20	204					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24509843	24509843	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:24509843C>T	ENST00000264463.4	-	7	1595	c.1088G>A	c.(1087-1089)gGa>gAa	p.G363E		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	363	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TTTAAATGGTCCTAGGTAATA	0.373000										HNSCC(23;0.051)			14	57					0	0	1	0	0
NCL	4691	broad.mit.edu	37	2	232320840	232320840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:232320840G>A	ENST00000322723.4	-	12	1953	c.1713C>T	c.(1711-1713)tcC>tcT	p.S571S		NM_005381.2	NP_005372.2	P19338	NUCL_HUMAN	nucleolin	571					angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ACAGAGTTTTGGATGGCTCTG	0.438000													16	50					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49211924	49211924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49211924C>T	ENST00000327979.2	-	16	2431	c.2020G>A	c.(2020-2022)Gca>Aca	p.A674T	FAM65C_ENST00000045083.2_Missense_Mutation_p.A674T|FAM65C_ENST00000535356.1_Missense_Mutation_p.A678T			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	674										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATGGATGTTGCCTTGCCGACC	0.552000													43	103					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6606396	6606396	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6606396C>T	ENST00000433363.2	-	5	842	c.609G>A	c.(607-609)agG>agA	p.R203R	SLC13A5_ENST00000293800.6_Silent_p.R186R|SLC13A5_ENST00000381074.4_Silent_p.R160R|SLC13A5_ENST00000573648.1_Silent_p.R203R	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	203						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						CCTTACACAACCTCTTCCGCT	0.627000													32	52					0	0	1	0	0
CSNK1D	1453	broad.mit.edu	37	17	80209291	80209291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80209291G>A	ENST00000314028.6	-	6	1198	c.849C>T	c.(847-849)tcC>tcT	p.S283S	CSNK1D_ENST00000578904.1_5'UTR|CSNK1D_ENST00000392334.2_Silent_p.S283S|CSNK1D_ENST00000398519.5_Silent_p.S283S	NM_001893.4	NP_001884.2	P48730	KC1D_HUMAN	casein kinase 1, delta	283					circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|large_intestine(2)|lung(7)	11	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			CGTAGTCATAGGAGAAGCCCT	0.532000													12	40					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156787340	156787340	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156787340C>T	ENST00000347377.6	+	25	3299	c.2868C>T	c.(2866-2868)ccC>ccT	p.P956P	CYFIP2_ENST00000541131.1_Silent_p.P881P|CYFIP2_ENST00000318218.6_Silent_p.P981P|CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000522463.1_Silent_p.P760P|CYFIP2_ENST00000521420.1_Silent_p.P930P|CYFIP2_ENST00000377576.3_Silent_p.P956P|CYFIP2_ENST00000435847.2_Silent_p.P655P	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	981					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGGTGATGCCCAAGATATGCC	0.527000													53	107					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1651957	1651957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1651957C>T	ENST00000252804.4	-	17	3645	c.3595G>A	c.(3595-3597)Gag>Aag	p.E1199K		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1199					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TTCAGTTTCTCCCGGATCTCA	0.517000													46	213					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109694813	109694813	+	Missense_Mutation	SNP	C	C	T	rs140162353	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:109694813C>T	ENST00000465301.2	+	3	1214	c.968C>T	c.(967-969)cCg>cTg	p.P323L	RGAG1_ENST00000540313.1_Missense_Mutation_p.P323L	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	323										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						ATGTCCACACCGCTACTGTCA	0.498000													11	240					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56757189	56757189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56757189C>T	ENST00000326855.2	+	1	843	c.801C>T	c.(799-801)tcC>tcT	p.S267S		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						CTAATAATTCCCAGGAAAATA	0.363000													29	64					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17692204	17692204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:17692204C>T	ENST00000399080.2	-	3	3370	c.3347G>A	c.(3346-3348)gGc>gAc	p.G1116D		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	1116	Interaction with RAD51.									endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TCTTGAAATGCCATGTGGAAA	0.323000													4	22					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933018	43933018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43933018C>T	ENST00000537548.1	-	4	737	c.493G>A	c.(493-495)Ggc>Agc	p.G165S	MATN4_ENST00000372751.4_Intron|MATN4_ENST00000353917.5_Missense_Mutation_p.G165S|MATN4_ENST00000342716.4_Missense_Mutation_p.G165S|MATN4_ENST00000372756.1_Missense_Mutation_p.G165S|MATN4_ENST00000360607.5_Missense_Mutation_p.G165S|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000372754.1_Missense_Mutation_p.G165S			O95460	MATN4_HUMAN	matrilin 4	165	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				ATTTCAATGCCGCGGGCGCGC	0.721000													5	22					0	0	1	0	0
IL36RN	26525	broad.mit.edu	37	2	113817030	113817030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113817030G>A	ENST00000393200.2	+	2	176	c.15G>A	c.(13-15)ggG>ggA	p.G5G	IL36RN_ENST00000346807.3_Silent_p.G5G	NM_012275.2	NP_036407.1	Q9UBH0	I36RA_HUMAN	interleukin 36 receptor antagonist	5						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						TCCTGAGTGGGGCGCTGTGCT	0.552000													16	54					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34770216	34770216	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34770216C>T	ENST00000338074.2	+	6	674	c.513C>T	c.(511-513)ttC>ttT	p.F171F	EPB41L1_ENST00000373946.3_Silent_p.F140F|EPB41L1_ENST00000373950.2_Silent_p.F74F|EPB41L1_ENST00000441639.1_Silent_p.F109F|EPB41L1_ENST00000202028.5_Silent_p.F109F|EPB41L1_ENST00000373941.1_Silent_p.F171F	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	171	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					ATTTTGCCTTCACAGTCAAGT	0.577000													27	61					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743149	26743149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26743149G>A	ENST00000396005.3	-	1	422	c.113C>T	c.(112-114)tCc>tTc	p.S38F	SLC5A12_ENST00000280467.6_Missense_Mutation_p.S38F	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	38					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GAACTCTCGGGAAGTTGCCTT	0.498000													80	38					0	0	1	0	0
HSD17B13	345275	broad.mit.edu	37	4	88243952	88243952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88243952G>A	ENST00000328546.4	-	1	106	c.42C>T	c.(40-42)atC>atT	p.I14I	RP11-529H2.2_ENST00000508163.1_RNA|HSD17B13_ENST00000302219.6_Silent_p.I14I	NM_178135.3	NP_835236.2	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	14						extracellular region	binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		AGGAGTAGATGATGGTGATCA	0.468000													19	47					0	0	1	0	0
LRRC2	79442	broad.mit.edu	37	3	46593050	46593050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46593050G>A	ENST00000395905.3	-	2	424	c.32C>T	c.(31-33)tCt>tTt	p.S11F	LRRC2_ENST00000496388.1_Intron|LRRC2_ENST00000296144.3_Missense_Mutation_p.S11F	NM_024512.4	NP_078788.2	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	11										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	17		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		TCTGATGACAGAAATGTCGAA	0.413000													42	90					0	0	1	0	0
CLIP4	79745	broad.mit.edu	37	2	29368177	29368177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29368177G>A	ENST00000320081.5	+	8	1220	c.965G>A	c.(964-966)gGa>gAa	p.G322E	CLIP4_ENST00000401605.1_Missense_Mutation_p.G322E|CLIP4_ENST00000401617.2_Missense_Mutation_p.G215E|CLIP4_ENST00000404424.1_Missense_Mutation_p.G322E	NM_024692.4	NP_078968.3	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family, member 4	322	CAP-Gly 1.									endometrium(4)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(1)	26	Acute lymphoblastic leukemia(172;0.155)					GAACCAGAAGGAAAAAATAAT	0.348000													17	68					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62738910	62738910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62738910C>T	ENST00000371153.4	-	3	2244	c.1866G>A	c.(1864-1866)aaG>aaA	p.K622K	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	622										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CCGGTGGCTCCTTGGGTGGGT	0.607000													23	41					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233348889	233348889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233348889C>T	ENST00000304546.1	-	7	1439	c.1229G>A	c.(1228-1230)aGt>aAt	p.S410N	ECEL1_ENST00000409941.1_Missense_Mutation_p.S410N	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	410					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CAGGTGTTCACTCAGGACCAC	0.647000													7	33					0	0	1	0	0
NOS1AP	9722	broad.mit.edu	37	1	162270444	162270444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:162270444G>A	ENST00000361897.5	+	4	694	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	NOS1AP_ENST00000530878.1_Missense_Mutation_p.E93K	NM_001164757.1|NM_014697.2	NP_001158229.1|NP_055512.1	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	98	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GCAGAAAAAGGAATGGACGTG	0.478000													32	97					0	0	1	0	0
GUCA1C	9626	broad.mit.edu	37	3	108626928	108626928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108626928C>T	ENST00000261047.3	-	4	703	c.571G>A	c.(571-573)Gag>Aag	p.E191K	GUCA1C_ENST00000393963.3_3'UTR	NM_005459.3	NP_005450.3	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	191					signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity			endometrium(2)|large_intestine(1)|liver(1)|lung(8)|pancreas(1)|skin(1)	14						GAGTCTGTCTCCATGTCTGGC	0.463000													4	60					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176947013	176947013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:176947013C>T	ENST00000308618.4	-	2	728	c.592G>A	c.(592-594)Gag>Aag	p.E198K		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	198						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GCGATCTGCTCGCGGGTGAAC	0.711000													4	19					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377343	55377343	+	Missense_Mutation	SNP	C	C	T	rs138402445		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55377343C>T	ENST00000326321.3	+	7	1117	c.1084C>T	c.(1084-1086)Cgc>Tgc	p.R362C	KIR3DL2_ENST00000270442.5_Missense_Mutation_p.R345C|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.R362C	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	362					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		tctcctTTATCGCTGGTGCTC	0.532000													13	43					0	0	1	0	0
DPH6	89978	broad.mit.edu	37	15	35742927	35742927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:35742927G>A	ENST00000256538.4	-	5	490	c.464C>T	c.(463-465)tCa>tTa	p.S155L		NM_080650.3	NP_542381.1			diphthamine biosynthesis 6																		AATGTTAGATGATATCATCTC	0.388000													32	85					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51752006	51752006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51752006C>T	ENST00000543196.2	-	8	1613	c.1408G>A	c.(1408-1410)Gaa>Aaa	p.E470K	GALNT6_ENST00000356317.3_Missense_Mutation_p.E470K			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	470					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TGCAGTTGTTCCCTCAGCTGC	0.463000													48	111					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222713440	222713440	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:222713440G>A	ENST00000343410.6	-	4	1420	c.1362C>T	c.(1360-1362)gaC>gaT	p.D454D		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	454					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		TCAAAATGAGGTCAACCTCTT	0.517000													45	112					0	0	1	0	0
PRODH	5625	broad.mit.edu	37	22	18909852	18909852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18909852G>A	ENST00000357068.6	-	7	1180	c.915C>T	c.(913-915)acC>acT	p.T305T	PRODH_ENST00000420436.1_Silent_p.T197T|PRODH_ENST00000334029.2_Silent_p.T197T	NM_016335.4	NP_057419.4	O43272	PROD_HUMAN	proline dehydrogenase (oxidase) 1	305					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)|endometrium(3)|lung(4)|upper_aerodigestive_tract(1)	9					L-Proline(DB00172)	ACACTCCCAGGGTCTCTGCCG	0.602000													7	31					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81056306	81056306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81056306C>T	ENST00000334512.5	+	13	1881	c.1309C>T	c.(1309-1311)Ccg>Tcg	p.P437S	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	437	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CCCCAACCCCCCGAGGCCACT	0.627000													66	118					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19236122	19236122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19236122C>T	ENST00000562034.1	+	5	4805	c.1007C>T	c.(1006-1008)cCc>cTc	p.P336L	SYT17_ENST00000568115.1_Missense_Mutation_p.P336L|SYT17_ENST00000562711.2_Missense_Mutation_p.P393L|SYT17_ENST00000568433.1_Missense_Mutation_p.P91L|SYT17_ENST00000355377.2_Missense_Mutation_p.P397L			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	397	C2 2.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						TTCAAAGTTCCCCAAGAAGAA	0.453000													24	75					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189612091	189612091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189612091C>T	ENST00000264731.3	+	14	1932	c.1843C>T	c.(1843-1845)Cat>Tat	p.H615Y	TP63_ENST00000449992.1_Missense_Mutation_p.H436Y|TP63_ENST00000320472.5_3'UTR|TP63_ENST00000456148.1_Missense_Mutation_p.H517Y|TP63_ENST00000382063.4_Missense_Mutation_p.H530Y|TP63_ENST00000354600.5_Missense_Mutation_p.H521Y|TP63_ENST00000440651.2_Missense_Mutation_p.H611Y	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	615	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CTCCCCTTCTCATCTCCTGCG	0.572000										HNSCC(45;0.13)			35	73					0	0	1	0	0
LTA4H	4048	broad.mit.edu	37	12	96421285	96421285	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:96421285G>A	ENST00000228740.2	-	3	489	c.348C>T	c.(346-348)ctC>ctT	p.L116L	RP11-256L6.2_ENST00000547346.1_RNA|LTA4H_ENST00000552789.1_Silent_p.L92L|LTA4H_ENST00000413268.2_Silent_p.L92L	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	116					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						TGAGCCACTGGAGAGCAGAAG	0.368000													14	78					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51411603	51411603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:51411603C>T	ENST00000319760.6	-	1	845	c.793G>A	c.(793-795)Gat>Aat	p.D265N		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				ATGAACTTATCAGTAGGAAAG	0.363000													21	73					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30982993	30982993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30982993C>T	ENST00000262519.8	+	13	3997	c.3311C>T	c.(3310-3312)cCa>cTa	p.P1104L		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	1104	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GCAGGCTCCCCAGTCACACCC	0.657000													14	39					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145439619	145439619	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145439619C>T	ENST00000511217.1	+	8	1798	c.1746C>T	c.(1744-1746)ctC>ctT	p.L582L	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Silent_p.L582L			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	582							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCCGCCCTCACGTGCATCA	0.622000													19	70					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50947861	50947861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50947861G>A	ENST00000374103.4	-	17	2250	c.2165C>T	c.(2164-2166)gCc>gTc	p.A722V	OGDHL_ENST00000419399.1_Missense_Mutation_p.A665V|OGDHL_ENST00000432695.1_Missense_Mutation_p.A513V	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	722					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						ATTGGGGCTGGCCATGGCATA	0.562000													17	37					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374045	27374045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27374045C>T	ENST00000395762.2	+	11	1631	c.1372C>T	c.(1372-1374)Ccc>Tcc	p.P458S	IL4R_ENST00000380922.3_Missense_Mutation_p.P443S|IL4R_ENST00000543915.2_Missense_Mutation_p.P458S|IL4R_ENST00000170630.2_Missense_Mutation_p.P458S	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	458	Required for IRS1 activation and IL4- induced cell growth.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GGAGGCACCTCCCTGGGGCAA	0.622000													17	69					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220356557	220356557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220356557G>A	ENST00000312358.7	+	39	9559	c.9427G>A	c.(9427-9429)Gac>Aac	p.D3143N	SPEG_ENST00000485813.1_3'UTR|AC053503.11_ENST00000429882.1_RNA	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	3143	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTCTGCCACGGACATCTGGGG	0.622000													10	27					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15688980	15688980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15688980C>T	ENST00000378076.3	-	12	1425	c.1072G>A	c.(1072-1074)Ggg>Agg	p.G358R		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	358					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TAGATTTGCCCTACTTCTCTG	0.507000													21	64					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8272584	8272584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8272584G>A	ENST00000396267.1	-	2	1932	c.1101C>T	c.(1099-1101)agC>agT	p.S367S	RP11-849F2.7_ENST00000582471.1_3'UTR|RP11-849F2.5_ENST00000580537.1_RNA|KRBA2_ENST00000331336.2_Silent_p.S449S|RP11-849F2.5_ENST00000583963.1_RNA			Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	449	Integrase catalytic.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(5)|stomach(1)|urinary_tract(1)	18						TGATCCAAAGGCTATTTTCTA	0.468000													56	84					0	0	1	0	0
C6orf201	404220	broad.mit.edu	37	6	4087912	4087912	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:4087912C>T	ENST00000380175.4	+	2	802	c.37C>T	c.(37-39)Ctg>Ttg	p.L13L	C6orf201_ENST00000430835.2_Silent_p.L13L|C6orf201_ENST00000360378.6_3'UTR|C6orf201_ENST00000333388.5_Intron	NM_001085401.2	NP_001078870.1	Q7Z4U5	CF201_HUMAN	chromosome 6 open reading frame 201	13										central_nervous_system(1)|endometrium(3)|lung(2)	6	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TCCGAATCACCTGATGGAGAC	0.488000													127	279					0	0	1	0	0
ZC4H2	55906	broad.mit.edu	37	X	64138976	64138976	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:64138976C>T	ENST00000545618.1	-	5	1055	c.492G>A	c.(490-492)agG>agA	p.R164R	ZC4H2_ENST00000374839.3_Silent_p.R169R|ZC4H2_ENST00000447788.2_Intron|ZC4H2_ENST00000337990.2_Silent_p.R146R|ZC4H2_ENST00000488608.1_5'UTR			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	169							metal ion binding|protein binding			endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TATCCTGCTTCCTAGCCACTT	0.597000													32	16					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4966352	4966352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:4966352G>A	ENST00000333703.4	+	5	1213	c.700G>A	c.(700-702)Gat>Aat	p.D234N	PCDH11Y_ENST00000362095.5_Missense_Mutation_p.D245N|PCDH11Y_ENST00000215473.6_Missense_Mutation_p.D245N	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	245	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GGAAGAGAAGGATACCTATGT	0.398000													61	102					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120438859	120438859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120438859G>A	ENST00000369400.1	-	1	259	c.101C>T	c.(100-102)cCt>cTt	p.P34L		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	34					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CTCCCCTTCAGGGTGAAAAAT	0.512000													10	55					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86089439	86089439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:86089439C>T	ENST00000330753.4	+	2	2348	c.1581C>T	c.(1579-1581)tcC>tcT	p.S527S	FLRT2_ENST00000554746.1_Silent_p.S527S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	527					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		ACACAGCGTCCAGCCATGAGC	0.587000													50	129					0	0	1	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307132	39307132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39307132G>A	ENST00000541347.1	-	2	1108	c.869C>T	c.(868-870)cCt>cTt	p.P290L	CX3CR1_ENST00000399220.2_Missense_Mutation_p.P290L|CX3CR1_ENST00000358309.3_Missense_Mutation_p.P322L|CX3CR1_ENST00000542107.1_Missense_Mutation_p.P290L	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	290					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		ATAGATGAGAGGATTCAGGCA	0.498000													41	87					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	432714	432714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:432714G>A	ENST00000256509.2	+	22	3305	c.2663G>A	c.(2662-2664)gGa>gAa	p.G888E	CHL1_ENST00000397491.2_Missense_Mutation_p.G872E	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	872	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGATTTTCAGGACAAAGAAAC	0.363000													31	69					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74708868	74708868	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:74708868G>A	ENST00000308807.7	-	10	1834	c.1371C>T	c.(1369-1371)ccC>ccT	p.P457P	MLKL_ENST00000306247.7_Silent_p.P249P	NM_152649.2	NP_689862.1	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like	457	Protein kinase.						ATP binding|protein binding|protein kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(6)|skin(1)|stomach(2)	19						CATCCACAGAGGGCCGCACAG	0.542000													24	55					0	0	1	0	0
SNORA71B	26776	broad.mit.edu	37	20	37053851	37053851	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:37053851G>A	ENST00000364546.1	-	0	128																											AGGCATGTACGAAAGCTCCAG	0.512000													37	78					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22310748	22310748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22310748C>T	ENST00000337107.6	+	6	585	c.566C>T	c.(565-567)tCc>tTc	p.S189F		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	189	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						GAACACTGCTCCAGGTGGAAC	0.607000													33	61					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3949556	3949556	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3949556G>A	ENST00000281228.8	-	0	653				FAM86EP_ENST00000313946.8_RNA																							GTCACCCTGGGGCCGTCTAAG	0.602000													8	54					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183446550	183446550	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183446550C>G	ENST00000305135.5	+	7	918	c.723C>G	c.(721-723)tcC>tcG	p.S241S		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	241	YEATS.				histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCCGAGGGTCCCGTAGAGAAC	0.413000													10	85					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76149896	76149896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76149896C>T	ENST00000298832.9	+	5	473	c.268C>T	c.(268-270)Cac>Tac	p.H90Y	TTLL5_ENST00000286650.5_Missense_Mutation_p.H90Y|TTLL5_ENST00000556977.1_Missense_Mutation_p.H90Y|TTLL5_ENST00000557636.1_Missense_Mutation_p.H90Y	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	90	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		CCCTCAGGTTCACCCAAGCAG	0.453000													28	83					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58063569	58063569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:58063569C>T	ENST00000339762.6	-	1	46	c.47G>A	c.(46-48)aGg>aAg	p.R16K	SLC35F4_ENST00000554729.1_5'UTR|SLC35F4_ENST00000556826.1_Intron|SLC35F4_ENST00000557430.1_Intron					solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGCCAGCTGCCTCCCACTGGT	0.413000													13	29					0	0	1	0	0
ANKRD6	22881	broad.mit.edu	37	6	90326361	90326361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:90326361G>A	ENST00000369408.5	+	8	1048	c.699G>A	c.(697-699)acG>acA	p.T233T	ANKRD6_ENST00000485637.1_Silent_p.T233T|ANKRD6_ENST00000447838.2_Silent_p.T233T|ANKRD6_ENST00000339746.4_Silent_p.T233T|ANKRD6_ENST00000520793.1_Silent_p.T200T|ANKRD6_ENST00000522441.1_Silent_p.T233T	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	233			T -> M (in dbSNP:rs2273238).				protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		GAGCAGATACGACCATTGTTA	0.473000													23	36					0	0	1	0	0
PEF1	553115	broad.mit.edu	37	1	32101117	32101117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32101117G>A	ENST00000373703.4	-	2	53	c.31C>T	c.(31-33)Cca>Tca	p.P11S	PEF1_ENST00000440872.2_Missense_Mutation_p.P11S|PEF1_ENST00000492061.1_5'UTR	NM_012392.3	NP_036524.1	Q9UBV8	PEF1_HUMAN	penta-EF-hand domain containing 1	11					response to calcium ion	cytoplasm|membrane	calcium ion binding|protein heterodimerization activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)	7		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)|all_neural(195;0.186)		STAD - Stomach adenocarcinoma(196;0.0546)		GCAGCTCCTGGGCAGCCCTGC	0.567000													8	17					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7611736	7611736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7611736G>A	ENST00000256861.6	-	12	2122	c.2044C>T	c.(2044-2046)Ccc>Tcc	p.P682S	ITIH5_ENST00000298441.6_Missense_Mutation_p.P468S|ITIH5_ENST00000446830.2_Missense_Mutation_p.P464S|ITIH5_ENST00000397146.2_Intron	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	682					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						ACAAAGTGGGGATCACCATCC	0.493000													6	25					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56544947	56544947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56544947C>T	ENST00000390649.3	+	9	2487	c.2487C>T	c.(2485-2487)ctC>ctT	p.L829L		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	829						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGCAGCACCTCTGGAGAATCG	0.488000													65	131					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139636053	139636053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139636053G>A	ENST00000263552.6	+	9	938	c.400G>A	c.(400-402)Gaa>Aaa	p.E134K	TBXAS1_ENST00000448866.1_Missense_Mutation_p.E133K|TBXAS1_ENST00000436047.2_Missense_Mutation_p.E134K|TBXAS1_ENST00000414508.2_Missense_Mutation_p.E134K|TBXAS1_ENST00000416849.2_Missense_Mutation_p.E134K|TBXAS1_ENST00000425687.1_Missense_Mutation_p.E66K|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000411653.1_Missense_Mutation_p.E133K|TBXAS1_ENST00000458722.1_Missense_Mutation_p.E133K|TBXAS1_ENST00000336425.5_Missense_Mutation_p.E133K	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	133					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CAAAAGATGGGAAGAGGTCAG	0.498000													78	180					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203197680	203197680	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203197680G>A	ENST00000367229.1	-	2	70	c.36C>T	c.(34-36)gtC>gtT	p.V12V	CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000535569.1_Silent_p.V22V|CHIT1_ENST00000255427.3_Silent_p.V12V	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	12					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						TCATCAGCAGGACCATGAAAC	0.562000													4	11					0	0	1	0	0
PRPF31	26121	broad.mit.edu	37	19	54626875	54626875	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54626875C>T	ENST00000321030.4	+	6	812	c.463C>T	c.(463-465)Ctg>Ttg	p.L155L	AC012314.8_ENST00000452097.1_RNA|PRPF31_ENST00000498612.1_3'UTR|PRPF31_ENST00000391755.1_Silent_p.L155L|PRPF31_ENST00000419967.1_Silent_p.L155L	NM_015629.3	NP_056444.3	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31	155					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)|urinary_tract(3)	12	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAATGAGAACCTGCAGCAGAT	0.612000													33	106					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776054	5776054	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5776054G>A	ENST00000317254.3	+	1	132	c.84G>A	c.(82-84)tgG>tgA	p.W28*	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CACAACTCTGGATTTCCTTCC	0.438000													27	69					0	0	1	0	0
PURG	29942	broad.mit.edu	37	8	30889533	30889533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30889533C>T	ENST00000475541.1	-	1	1698	c.766G>A	c.(766-768)Gat>Aat	p.D256N	PURG_ENST00000339382.2_Missense_Mutation_p.D256N	NM_013357.2	NP_037489.1	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G	256						nucleus	DNA binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		AGCGGGTCATCGTCTCCACCT	0.453000													26	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604077	179604077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179604077G>A	ENST00000589042.1	-	48	14107	c.13883C>T	c.(13882-13884)tCc>tTc	p.S4628F	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S4311F|TTN_ENST00000342175.6_Missense_Mutation_p.S4457F|TTN_ENST00000359218.5_Missense_Mutation_p.S4390F|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S4265F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4311	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTGTTATGGATGTTGTGAG	0.388000													7	51					0	0	1	0	0
DNAH14	127602	broad.mit.edu	37	1	225140444	225140444	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:225140444C>T	ENST00000430092.1	+	2	255	c.40C>T	c.(40-42)Caa>Taa	p.Q14*	DNAH14_ENST00000498360.1_3'UTR|DNAH14_ENST00000366849.1_Nonsense_Mutation_p.Q14*|DNAH14_ENST00000366850.3_Nonsense_Mutation_p.Q14*|DNAH14_ENST00000439375.2_Nonsense_Mutation_p.Q14*|DNAH14_ENST00000366848.1_Nonsense_Mutation_p.Q14*|DNAH14_ENST00000400952.3_Nonsense_Mutation_p.Q14*	NM_001373.1	NP_001364.1	Q0VDD8	DYH14_HUMAN	dynein, axonemal, heavy chain 14	191					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(2)|lung(2)|skin(2)|stomach(1)	27						AACTGAAAATCAAGAGATGGA	0.308000													7	21					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45353847	45353847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45353847G>A	ENST00000359271.2	+	2	422	c.172G>A	c.(172-174)Gct>Act	p.A58T		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	58						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				GCTCCTGGGGGCTCTCCTCGC	0.607000													15	43					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168104111	168104111	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168104111G>A	ENST00000409195.1	+	9	6298	c.6209G>A	c.(6208-6210)gGa>gAa	p.G2070E	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.G2070E|XIRP2_ENST00000409273.1_Missense_Mutation_p.G1848E|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1895					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATACTACAGGAGAACAGCAT	0.378000													13	76					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087032	92087032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92087032G>A	ENST00000298047.6	+	1	1771	c.1754G>A	c.(1753-1755)gGa>gAa	p.G585E	FAT3_ENST00000525166.1_Missense_Mutation_p.G435E|FAT3_ENST00000409404.2_Missense_Mutation_p.G585E|FAT3_ENST00000541502.1_Missense_Mutation_p.G585E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	585	Cadherin 6.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTTGCCAGGGAGTTATTTCA	0.428000										TCGA Ovarian(4;0.039)			14	29					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157772251	157772251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157772251C>T	ENST00000358292.3	-	4	574	c.523G>A	c.(523-525)Gag>Aag	p.E175K	FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.E175K|FCRL1_ENST00000368176.3_Missense_Mutation_p.E175K	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	175	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity	p.E175*(2)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GCATCACTCTCCCTCACTGAA	0.488000													28	72					0	0	1	0	0
PGBD5	79605	broad.mit.edu	37	1	230492691	230492691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230492691G>A	ENST00000321327.2	-	4	797	c.798C>T	c.(796-798)ctC>ctT	p.L266L	PGBD5_ENST00000391860.1_Silent_p.L121L|PGBD5_ENST00000525115.1_Silent_p.L167L			Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	167						integral to membrane				biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(2)|skin(1)	33	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		GCAGGGAGTCGAGGAAGGGCT	0.612000													20	67					0	0	1	0	0
SULT1C4	27233	broad.mit.edu	37	2	108998259	108998259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108998259G>A	ENST00000272452.2	+	2	537	c.211G>A	c.(211-213)Gaa>Aaa	p.E71K	SULT1C4_ENST00000409309.3_Missense_Mutation_p.E71K	NM_006588.2	NP_006579.2	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member 4	71					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						AATACAAAATGAAGGTGATGT	0.378000													20	51					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156476087	156476087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156476087C>T	ENST00000339252.3	-	4	1275	c.743G>A	c.(742-744)aGa>aAa	p.R248K	HAVCR1_ENST00000544197.1_Missense_Mutation_p.R248K|HAVCR1_ENST00000523175.1_Missense_Mutation_p.R248K|HAVCR1_ENST00000425854.1_Missense_Mutation_p.R248K|HAVCR1_ENST00000517644.1_5'UTR|HAVCR1_ENST00000522693.1_Missense_Mutation_p.R248K	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	243					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGGGTTCTCTCCTTATTGC	0.463000													39	86					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15132675	15132675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15132675C>T	ENST00000292574.3	+	6	1277	c.1195C>T	c.(1195-1197)Cgc>Tgc	p.R399C		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	399					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						ACCCCTGGTTCGCATGTACCA	0.637000													33	58					0	0	1	0	0
IFNA6	3443	broad.mit.edu	37	9	21350466	21350466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21350466G>A	ENST00000380210.1	-	1	911	c.421C>T	c.(421-423)Ctg>Ttg	p.L141L		NM_021002.2	NP_066282.1	P05013	IFNA6_HUMAN	interferon, alpha 6	141					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			large_intestine(3)|lung(7)|skin(1)	11				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		CTCACAGCCAGGATGGAGTCC	0.493000													46	335					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491646	100491646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100491646C>T	ENST00000302913.4	-	2	346	c.208G>A	c.(208-210)Gag>Aag	p.E70K	ACHE_ENST00000428317.1_Missense_Mutation_p.E70K|ACHE_ENST00000412389.1_Missense_Mutation_p.E70K|ACHE_ENST00000411582.1_Missense_Mutation_p.E70K|ACHE_ENST00000241069.5_Missense_Mutation_p.E70K|ACHE_ENST00000419336.2_Missense_Mutation_p.E70K	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	70					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	ATGGGTGGCTCCGCAAAGGGG	0.652000													8	24					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111195317	111195317	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:111195317G>A	ENST00000262839.2	-	2	1250	c.332C>T	c.(331-333)gCt>gTt	p.A111V		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	111					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAGCTCCACAGCGCCCACCAC	0.542000													17	74					0	0	1	0	0
ZNF317	57693	broad.mit.edu	37	19	9271434	9271434	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9271434C>T	ENST00000247956.6	+	7	1418	c.1113C>T	c.(1111-1113)ttC>ttT	p.F371F	ZNF317_ENST00000360385.3_Silent_p.F339F	NM_020933.4	NP_065984.3	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	27						GCAAAGCCTTCCGCTGGAAGT	0.537000													9	27					0	0	1	0	0
ABCC6P1	653190	broad.mit.edu	37	16	18603886	18603886	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:18603886C>T	ENST00000546162.2	+	0	1229					NR_003569.1																						TATTGGTGATCCCAAGCCTCC	0.562000													13	19					0	0	1	0	0
CNNM3	26505	broad.mit.edu	37	2	97494389	97494389	+	Nonsense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97494389T>G	ENST00000305510.3	+	6	1900	c.1872T>G	c.(1870-1872)taT>taG	p.Y624*	CNNM3_ENST00000480035.1_3'UTR|CNNM3_ENST00000377060.3_Nonsense_Mutation_p.Y576*|ANKRD23_ENST00000476975.1_Intron	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	624					ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						CATCTGCGTATTGTCCCGACT	0.592000													23	35					0	0	1	0	0
SLC29A3	55315	broad.mit.edu	37	10	73122030	73122030	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73122030C>T	ENST00000373189.5	+	6	1145	c.1093C>T	c.(1093-1095)Ctc>Ttc	p.L365F	SLC29A3_ENST00000469204.1_3'UTR	NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	365					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						TGGCCGGCAGCTCACCGCCTG	0.592000													66	208					0	0	1	0	0
GEMIN7	79760	broad.mit.edu	37	19	45593555	45593555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45593555C>T	ENST00000270257.4	+	3	430	c.183C>T	c.(181-183)gcC>gcT	p.A61A	GEMIN7_ENST00000591747.1_Silent_p.A61A|CTB-179K24.4_ENST00000586744.1_RNA|CTB-179K24.3_ENST00000586556.1_RNA|GEMIN7_ENST00000591607.1_Silent_p.A61A|GEMIN7_ENST00000391951.2_Silent_p.A61A	NM_001007269.1|NM_001007270.1|NM_024707.2	NP_001007270.1|NP_001007271.1|NP_078983.1	Q9H840	GEMI7_HUMAN	gem (nuclear organelle) associated protein 7	61					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			endometrium(1)|kidney(1)|lung(4)|ovary(1)	7		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		CACGAGCCGCCCTTCGGGAGC	0.627000													8	44					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207307839	207307839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207307839G>A	ENST00000367070.3	+	9	1369	c.1175G>A	c.(1174-1176)gGa>gAa	p.G392E		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	392	Sushi 6.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TATTTCTATGGAGATGAGATT	0.423000													43	133					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61940042	61940042	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61940042G>A	ENST00000422202.1	+	7	1013	c.945G>A	c.(943-945)gtG>gtA	p.V315V	COL20A1_ENST00000326996.6_Silent_p.V308V|COL20A1_ENST00000435874.1_Silent_p.V315V|COL20A1_ENST00000358894.6_Silent_p.V308V			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	308	VWFA.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					ACCTGGGCGTGAACGTCTTCG	0.657000													8	8					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17122442	17122442	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17122442G>A	ENST00000443236.1	-	4	565	c.534C>T	c.(532-534)ttC>ttT	p.F178F	CTD-2528A14.1_ENST00000595134.1_RNA|CPAMD8_ENST00000388925.4_Silent_p.F131F	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	131						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CCGTCTGGATGAATACAGAAG	0.657000													44	113					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52264053	52264053	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:52264053G>A	ENST00000354831.7	-	24	2865	c.2676C>T	c.(2674-2676)gcC>gcT	p.A892A	NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000539524.1_Silent_p.A760A|NRD1_ENST00000544028.1_Silent_p.A692A|RP4-657D16.3_ENST00000586761.1_RNA|RP4-657D16.3_ENST00000591675.1_RNA|NRD1_ENST00000352171.7_Silent_p.A824A|RP4-657D16.3_ENST00000588291.1_RNA	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	823					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TAGACCAACGGGCATATTCCA	0.403000													28	65					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51243806	51243806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51243806G>A	ENST00000245441.5	-	7	717	c.527C>T	c.(526-528)tCt>tTt	p.S176F	NIN_ENST00000530997.2_Missense_Mutation_p.S176F|NIN_ENST00000453196.1_Missense_Mutation_p.S176F|NIN_ENST00000382041.3_Missense_Mutation_p.S176F|NIN_ENST00000324330.9_Missense_Mutation_p.S176F|NIN_ENST00000389868.3_Missense_Mutation_p.S176F|NIN_ENST00000382043.4_Missense_Mutation_p.S176F	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	176					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					GGGAGGGGAAGATCCACTCTG	0.478000			T	PDGFRB	MPD								26	85					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175097744	175097744	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175097744C>T	ENST00000239462.4	+	15	3305	c.3192C>T	c.(3190-3192)ttC>ttT	p.F1064F		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1064	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GTGCCCGTTTCCCACACCCTT	0.537000													31	80					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47432807	47432807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47432807C>T	ENST00000285039.7	-	19	2695	c.2396G>A	c.(2395-2397)cGg>cAg	p.R799Q		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	799	IQ 2.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CAGGTGTCCCCGGCAGTACCT	0.582000													7	51					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36170723	36170723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:36170723G>A	ENST00000335119.2	+	1	1335	c.1224G>A	c.(1222-1224)aaG>aaA	p.K408K		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	408					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			TGGCAGGAAAGATGAGCATCC	0.547000													28	68					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18643341	18643341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:18643341G>A	ENST00000379989.3	+	18	2755	c.2470G>A	c.(2470-2472)Gag>Aag	p.E824K	CDKL5_ENST00000379996.3_Missense_Mutation_p.E824K	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	824					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					GTGGCGCCCCGAGAAGATCTC	0.547000													66	42					0	0	1	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103601679	103601679	+	Silent	SNP	C	C	T	rs146608837	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103601679C>T	ENST00000560869.1	+	12	2586	c.1947C>T	c.(1945-1947)tcC>tcT	p.S649S	TNFAIP2_ENST00000538222.1_Silent_p.S132S|TNFAIP2_ENST00000451723.2_Silent_p.S318S|TNFAIP2_ENST00000333007.1_Silent_p.S649S			Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	649					angiogenesis|cell differentiation	extracellular space				NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	11		Melanoma(154;0.155)	Epithelial(46;0.191)			CCCTATTTTCCCTTATAAAGG	0.597000													97	215					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123970966	123970966	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123970966G>A	ENST00000369005.1	+	9	7366	c.7026G>A	c.(7024-7026)tgG>tgA	p.W2342*	TACC2_ENST00000368999.1_Nonsense_Mutation_p.W420*|TACC2_ENST00000369004.3_Nonsense_Mutation_p.W420*|TACC2_ENST00000513429.1_Nonsense_Mutation_p.W488*|TACC2_ENST00000358010.1_Nonsense_Mutation_p.W488*|TACC2_ENST00000369000.1_Nonsense_Mutation_p.W46*|TACC2_ENST00000515603.1_Nonsense_Mutation_p.W2297*|TACC2_ENST00000369001.1_Nonsense_Mutation_p.W46*|TACC2_ENST00000334433.3_Nonsense_Mutation_p.W2342*|TACC2_ENST00000360561.3_Nonsense_Mutation_p.W420*|TACC2_ENST00000515273.1_Nonsense_Mutation_p.W2346*|TACC2_ENST00000453444.2_Nonsense_Mutation_p.W2346*|TACC2_ENST00000260733.3_Nonsense_Mutation_p.W420*	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2342	SPAZ.					microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTGACAAGTGGGATGACCCCA	0.463000													111	248					0	0	1	0	0
HIST1H3F	8968	broad.mit.edu	37	6	26250518	26250518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26250518C>T	ENST00000446824.2	-	1	317	c.316G>A	c.(316-318)Gag>Aag	p.E106K		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	106					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			lung(6)|urinary_tract(1)	7						TTGGTGTCCTCAAAGAGCCCC	0.602000											OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	147					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3658802	3658802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:3658802G>A	ENST00000404826.2	+	2	528	c.389G>A	c.(388-390)gGg>gAg	p.G130E	SDK1_ENST00000389531.3_Missense_Mutation_p.G130E	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	130	Ig-like C2-type 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTTGCCGAAGGGAGCTGGCCT	0.478000													9	53					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30973981	30973981	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:30973981G>A	ENST00000295055.8	-	11	1400	c.1224C>T	c.(1222-1224)ttC>ttT	p.F408F	CAPN13_ENST00000534090.2_Silent_p.F408F	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	408					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GAATCACTTGGAAATCGAGTG	0.473000													9	17					0	0	1	0	0
THSD1	55901	broad.mit.edu	37	13	52952628	52952628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52952628C>T	ENST00000349258.4	-	4	1862	c.1318G>A	c.(1318-1320)Ggc>Agc	p.G440S	THSD1_ENST00000258613.4_Missense_Mutation_p.G493S|THSD1_ENST00000544466.1_Missense_Mutation_p.G114S	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	493						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		AGAGGGATGCCTGTGTCCCCT	0.647000													21	69					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18436239	18436239	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:18436239G>A	ENST00000338745.6	-	7	2655	c.921C>T	c.(919-921)ctC>ctT	p.L307L	SATB1_ENST00000417717.2_Silent_p.L307L|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Silent_p.L307L	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	307					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						GTGTTGATACGAGCCCAGGGT	0.572000													22	99					0	0	1	0	0
TECTB	6975	broad.mit.edu	37	10	114061871	114061871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:114061871C>T	ENST00000369422.3	+	9	920	c.920C>T	c.(919-921)tCc>tTc	p.S307F	TECTB_ENST00000494328.1_3'UTR	NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	307						anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		AGGGGATTTTCCAGTCTCTAT	0.403000													49	112					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170103479	170103479	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170103479G>A	ENST00000263816.3	-	21	3211	c.2926C>T	c.(2926-2928)Caa>Taa	p.Q976*	LRP2_ENST00000443831.1_Nonsense_Mutation_p.Q839*	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	976	EGF-like 4.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGCGTGGGTTGATTACAGGCG	0.502000													8	34					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406335	55406335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55406335G>A	ENST00000314612.2	+	1	502	c.502G>A	c.(502-504)Ggc>Agc	p.G168S		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						ACCATTTTGTGGCCCAAATGA	0.388000													29	66					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39229826	39229826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39229826C>T	ENST00000340369.3	-	2	1339	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.E371K	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	371							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		ACCACTTCCTCCTTGGGTGGG	0.582000													72	177					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183944265	183944265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183944265C>T	ENST00000361927.4	-	3	829	c.458G>A	c.(457-459)cGa>cAa	p.R153Q	COLGALT2_ENST00000546159.1_Missense_Mutation_p.R153Q	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2									p.R153Q(1)									CCTCGCAGTTCGAAGGGCTGC	0.423000													32	86					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179437688	179437688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179437688G>A	ENST00000367618.3	+	17	2296	c.1909G>A	c.(1909-1911)Gaa>Aaa	p.E637K	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	637										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GGAAATAGATGAAAAAATTAA	0.353000													29	67					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157665230	157665230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157665230C>T	ENST00000368184.3	-	8	1591	c.1300G>A	c.(1300-1302)Gga>Aga	p.G434R	FCRL3_ENST00000368186.5_Missense_Mutation_p.G434R|RP11-367J7.3_ENST00000453692.1_RNA|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	434	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AAGGAGGCTCCTCCTCCAGAG	0.562000													45	150					0	0	1	0	0
PPT1	5538	broad.mit.edu	37	1	40555169	40555169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40555169G>A	ENST00000433473.3	-	5	913	c.449C>T	c.(448-450)cCt>cTt	p.P150L	PPT1_ENST00000449045.2_Missense_Mutation_p.P47L	NM_000310.3	NP_000301.1	P50897	PPT1_HUMAN	palmitoyl-protein thioesterase 1	150					brain development|cofactor metabolic process|cofactor transport|DNA fragmentation involved in apoptotic nuclear change|lysosomal lumen acidification|membrane raft organization|negative regulation of cell growth|negative regulation of neuron apoptosis|neuron development|pinocytosis|positive regulation of pinocytosis|positive regulation of receptor-mediated endocytosis|protein depalmitoylation|protein transport|receptor-mediated endocytosis|regulation of synapse structure and activity|sphingolipid catabolic process|visual perception	axon|cytosol|Golgi apparatus|lysosome|membrane fraction|membrane raft|nucleus|synaptic vesicle	palmitoyl-(protein) hydrolase activity|palmitoyl-CoA hydrolase activity	p.P150H(1)		endometrium(5)|large_intestine(1)|lung(3)|ovary(1)|stomach(1)	11	Lung NSC(20;3.43e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1e-18)|Epithelial(16;3.6e-17)|all cancers(16;1.1e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGGGCATCGAGGGAGTCCAAA	0.443000													18	68					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29390737	29390737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:29390737C>T	ENST00000558402.1	+	10	1895	c.1296C>T	c.(1294-1296)ttC>ttT	p.F432F	APBA2_ENST00000411764.1_Silent_p.F420F|APBA2_ENST00000558330.1_Silent_p.F420F|APBA2_ENST00000558259.1_Silent_p.F432F|APBA2_ENST00000561069.1_Silent_p.F432F			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	432	PID.				nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TGGACCTCTTCATTTCCACCC	0.443000													19	62					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21730468	21730468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21730468G>A	ENST00000328843.6	+	36	6062	c.6031G>A	c.(6031-6033)Gaa>Aaa	p.E2011K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E2004K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2011	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGGTCGAACCGAATTACCGGA	0.413000									Kartagener syndrome				31	195					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1734100	1734100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1734100C>T	ENST00000381241.3	+	1	207	c.8C>T	c.(7-9)tCc>tTc	p.S3F	ASMT_ENST00000381233.3_Missense_Mutation_p.S3F|ASMT_ENST00000381229.4_Missense_Mutation_p.S3F	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	3					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AAGATGGGATCCTCAGAGGAC	0.592000													5	10					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187840	152187840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152187840C>T	ENST00000368801.2	-	3	6340	c.6265G>A	c.(6265-6267)Ggt>Agt	p.G2089S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2089					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAAGACCGACCGGAGCCAGAC	0.622000													45	121					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87615822	87615822	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87615822C>T	ENST00000327946.7	-	7	1162	c.1077G>A	c.(1075-1077)tgG>tgA	p.W359*		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	359						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCCCACCATTCCATGGCTTAG	0.552000										Multiple Myeloma(13;0.14)			10	98					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168175434	168175434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168175434C>T	ENST00000519560.1	-	20	2562	c.2143G>A	c.(2143-2145)Gag>Aag	p.E715K	SLIT3_ENST00000332966.8_Missense_Mutation_p.E715K|SLIT3_ENST00000404867.3_Missense_Mutation_p.E715K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	715					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTACTCTCCTCGTTGCCTGTG	0.632000													8	49					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19544092	19544092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:19544092C>T	ENST00000507958.1	-	11	2266	c.1276G>A	c.(1276-1278)Gaa>Aaa	p.E426K	CDH18_ENST00000506372.1_Missense_Mutation_p.E426K|CDH18_ENST00000382275.1_Missense_Mutation_p.E426K|CDH18_ENST00000274170.4_Missense_Mutation_p.E426K|CDH18_ENST00000502796.1_Missense_Mutation_p.E426K|CDH18_ENST00000511273.1_Missense_Mutation_p.E426K			Q13634	CAD18_HUMAN	cadherin 18, type 2	426	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTGTCGTCTTCAACATTGTAG	0.343000													26	33					0	0	1	0	0
PKIA	5569	broad.mit.edu	37	8	79513998	79513998	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:79513998G>A	ENST00000396418.2	+	4	659	c.173G>A	c.(172-174)cGa>cAa	p.R58Q	PKIA_ENST00000352966.5_Missense_Mutation_p.R58Q|PKIA_ENST00000518467.1_Missense_Mutation_p.R58Q	NM_006823.3|NM_181839.2	NP_006814.1|NP_862822.1	P61925	IPKA_HUMAN	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	58							cAMP-dependent protein kinase inhibitor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	6						GATGCACAACGAAGTTCTACA	0.388000													7	31					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20676384	20676384	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20676384G>A	ENST00000525748.1	+	16	2637	c.2364G>A	c.(2362-2364)gtG>gtA	p.V788V	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	788					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	AACTGCCAGTGAAGGATTTGG	0.532000													64	143					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30318780	30318780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30318780G>A	ENST00000375377.1	-	3	398	c.297C>T	c.(295-297)ccC>ccT	p.P99P		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	99										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ATGCTGAGGGGGGTTGATTAC	0.512000													6	33					0	0	1	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032136	46032136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46032136C>T	ENST00000334662.2	+	1	141	c.119C>T	c.(118-120)tCc>tTc	p.S40F	TSPEAR_ENST00000323084.4_Intron	NM_198695.2	NP_941968.2	P60410	KR108_HUMAN	keratin associated protein 10-8	40	19 X 5 AA repeats of C-C-X(3).					keratin filament				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	17						ACTGGCTCCTCCTGGCAGGTG	0.642000													15	109					0	0	1	0	0
CSF3	1440	broad.mit.edu	37	17	38172548	38172548	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38172548C>T	ENST00000331769.2	+	2	462	c.246C>T	c.(244-246)atC>atT	p.I82I	CSF3_ENST00000394148.3_Intron|CSF3_ENST00000577675.1_Intron|CSF3_ENST00000225474.2_Silent_p.I89I|CSF3_ENST00000394149.3_Silent_p.I86I			P09919	CSF3_HUMAN	colony stimulating factor 3 (granulocyte)	89					cytokine-mediated signaling pathway|granulocyte differentiation|immune response|positive regulation of cell proliferation	extracellular space	cytokine activity|enzyme binding|granulocyte colony-stimulating factor receptor binding|growth factor activity			endometrium(1)|ovary(1)|prostate(1)	3	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CTCTGGGCATCCCCTGGGCTC	0.627000													5	5					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584424	1584424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1584424C>T	ENST00000381297.4	-	2	1238	c.1028G>A	c.(1027-1029)gGg>gAg	p.G343E		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	343						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCCCTCCATCCCTTCAGGGTG	0.711000			T	CRLF2	"""B-ALL, Downs associated ALL"""								33	81					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41142988	41142988	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41142988C>T	ENST00000263413.3	-	18	3008	c.2744G>A	c.(2743-2745)gGa>gAa	p.G915E	C6_ENST00000337836.5_Missense_Mutation_p.G915E	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	915	C5b-binding domain.|Complement control factor I module 2.|Kazal-like 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCTTATAGTTCCCACTTCACA	0.438000													30	72					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281792	152281792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152281792C>T	ENST00000368799.1	-	3	5605	c.5570G>A	c.(5569-5571)gGg>gAg	p.G1857E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1857	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGACTGCCCACGGGAGAC	0.542000									Ichthyosis				164	478					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313098	54313098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54313098G>A	ENST00000324134.6	-	3	1983	c.1815C>T	c.(1813-1815)acC>acT	p.T605T	NLRP12_ENST00000354278.3_Silent_p.T605T|NLRP12_ENST00000391772.1_Silent_p.T605T|NLRP12_ENST00000351894.4_Silent_p.T605T|NLRP12_ENST00000391775.3_Silent_p.T605T|NLRP12_ENST00000535162.1_Silent_p.T605T|NLRP12_ENST00000345770.5_Silent_p.T605T|NLRP12_ENST00000391773.1_Silent_p.T605T	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	605					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCTGCTGCAGGGTGGAGCCGT	0.577000													25	81					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97658696	97658696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:97658696C>T	ENST00000370192.3	-	20	2651	c.2551G>A	c.(2551-2553)Gga>Aga	p.G851R	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	851					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GGACTCTGTCCATCCCAGTCT	0.448000													32	62					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776262	5776262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5776262G>A	ENST00000317254.3	+	1	340	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TGGATTTGATGAATGCCTTGT	0.488000													25	78					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58036612	58036612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:58036612G>A	ENST00000556826.1	-	6	1256	c.1020C>T	c.(1018-1020)ttC>ttT	p.F340F	SLC35F4_ENST00000554729.1_Silent_p.F217F|SLC35F4_ENST00000339762.6_Silent_p.F376F	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGAAGGAGATGAAGATCAAAT	0.483000													4	12					0	0	1	0	0
DLL3	10683	broad.mit.edu	37	19	39998532	39998532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39998532C>T	ENST00000205143.4	+	8	1743	c.1736C>T	c.(1735-1737)gCt>gTt	p.A579V	DLL3_ENST00000356433.5_Missense_Mutation_p.A579V	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	579					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTCATATCTGCTCCTTCCATC	0.547000													17	58					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56203125	56203125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56203125C>T	ENST00000361673.3	-	5	4507	c.4294G>A	c.(4294-4296)Gaa>Aaa	p.E1432K	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1432							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TGACCCCCTTCTCTGGCGCCC	0.512000													17	91					0	0	1	0	0
IRF6	3664	broad.mit.edu	37	1	209961966	209961966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209961966C>T	ENST00000367021.3	-	9	1375	c.1203G>A	c.(1201-1203)atG>atA	p.M401I	IRF6_ENST00000542854.1_Missense_Mutation_p.M306I	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	401					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TCTCGTAGATCATCCGAGCCA	0.453000										HNSCC(57;0.16)			4	22					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71634886	71634886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71634886G>A	ENST00000356340.3	+	4	938	c.402G>A	c.(400-402)ggG>ggA	p.G134G	COL13A1_ENST00000517713.1_Silent_p.G134G|COL13A1_ENST00000398973.3_Silent_p.G134G|COL13A1_ENST00000398972.3_Silent_p.G134G|COL13A1_ENST00000357811.3_Silent_p.G134G|COL13A1_ENST00000398966.3_Silent_p.G134G|COL13A1_ENST00000522165.1_Silent_p.G134G|COL13A1_ENST00000398971.3_Silent_p.G134G|COL13A1_ENST00000520133.1_Intron|COL13A1_ENST00000520267.1_Intron|COL13A1_ENST00000398968.3_Silent_p.G134G|COL13A1_ENST00000398978.3_Silent_p.G134G|COL13A1_ENST00000398974.3_Intron|COL13A1_ENST00000398964.3_Intron|COL13A1_ENST00000354547.3_Silent_p.G134G|COL13A1_ENST00000398969.3_Intron			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	134	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	ATCATCAGGGGGACAAAGGTG	0.547000													12	33					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3322099	3322099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3322099C>T	ENST00000378398.3	+	9	1158	c.1076C>T	c.(1075-1077)tCg>tTg	p.S359L	PRDM16_ENST00000378391.2_Missense_Mutation_p.S358L|PRDM16_ENST00000442529.2_Missense_Mutation_p.S358L|PRDM16_ENST00000441472.2_Missense_Mutation_p.S358L|PRDM16_ENST00000514189.1_Missense_Mutation_p.S359L|PRDM16_ENST00000511072.1_Missense_Mutation_p.S359L|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Missense_Mutation_p.S358L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	358					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CACATCCGCTCGCAGCACGTG	0.682000			T	EVI1	"""MDS, AML"""								19	57					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105451060	105451060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105451060G>A	ENST00000337685.2	+	5	2420	c.1635G>A	c.(1633-1635)atG>atA	p.M545I	MUM1L1_ENST00000357175.2_Missense_Mutation_p.M545I|MUM1L1_ENST00000372552.1_Missense_Mutation_p.M545I	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	545										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						CTGACCGGATGAAGGCTGCTC	0.468000													9	9					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115220557	115220557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115220557C>T	ENST00000369538.3	-	8	1332	c.1285G>A	c.(1285-1287)Ggg>Agg	p.G429R	AMPD1_ENST00000353928.6_Missense_Mutation_p.G400R|AMPD1_ENST00000520113.2_Missense_Mutation_p.G433R	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	400					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AAATATTCCCCATTAATGTAA	0.433000													19	148					0	0	1	0	0
CLDN6	9074	broad.mit.edu	37	16	3065728	3065728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3065728G>A	ENST00000396925.1	-	3	723	c.295C>T	c.(295-297)Ctt>Ttt	p.L99F	CLDN6_ENST00000572154.1_Intron|CLDN6_ENST00000328796.4_Missense_Mutation_p.L99F			P56747	CLD6_HUMAN	claudin 6	99					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GCCCCAGCAAGGTAGACCAGC	0.612000													16	45					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1246138	1246138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1246138C>T	ENST00000324642.3	+	12	1955	c.1832C>T	c.(1831-1833)cCg>cTg	p.P611L		NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	611					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GACATGCGCCCGGACACGGAC	0.746000													4	8					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480155	73480155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73480155G>A	ENST00000523207.1	+	2	774	c.186G>A	c.(184-186)ggG>ggA	p.G62G		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	62					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CGCGCCTGGGGAAGCTTCGAG	0.552000													23	105					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79092829	79092829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79092829C>T	ENST00000388820.4	-	2	371	c.161G>A	c.(160-162)gGg>gAg	p.G54E	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	54					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GAAGGAGCCCCCCGCGTCGAC	0.672000													6	12					0	0	1	0	0
NRSN1	140767	broad.mit.edu	37	6	24134672	24134672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24134672C>T	ENST00000378491.4	+	3	418	c.117C>T	c.(115-117)gcC>gcT	p.A39A	NRSN1_ENST00000378478.1_Silent_p.A39A|NRSN1_ENST00000378475.1_Silent_p.A39A	NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	39					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						ACTGTACAGCCTCAATTTGGG	0.507000													28	51					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766216	77766216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77766216G>A	ENST00000521891.2	+	10	7507	c.7059G>A	c.(7057-7059)atG>atA	p.M2353I	ZFHX4_ENST00000455469.2_Missense_Mutation_p.M2308I|ZFHX4_ENST00000050961.6_Missense_Mutation_p.M2308I|ZFHX4_ENST00000518282.1_Missense_Mutation_p.M2327I	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2308	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAGACTCCATGGATGCCACTG	0.473000										HNSCC(33;0.089)			42	118					0	0	1	0	0
THOC6	79228	broad.mit.edu	37	16	3077236	3077236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3077236C>T	ENST00000326266.8	+	11	1061	c.765C>T	c.(763-765)ttC>ttT	p.F255F	THOC6_ENST00000253952.9_Silent_p.F255F|THOC6_ENST00000574549.1_Silent_p.F231F|THOC6_ENST00000575576.1_Silent_p.F231F	NM_024339.3	NP_077315.2	Q86W42	THOC6_HUMAN	THO complex 6 homolog (Drosophila)	255					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	13						CCACCATCTTCCCCATCCGGG	0.632000													25	93					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111432842	111432842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111432842C>T	ENST00000393934.3	+	3	1303	c.733C>T	c.(733-735)Ctc>Ttc	p.L245F	PLCXD2_ENST00000477665.1_Missense_Mutation_p.L245F|PLCXD2_ENST00000472215.1_3'UTR	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	245					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CAAACTAATCCTCTTCTTGGA	0.567000													32	72					0	0	1	0	0
PRB3	5544	broad.mit.edu	37	12	11420567	11420567	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11420567C>T	ENST00000381842.3	-	0	642				PRB3_ENST00000538488.1_RNA|PRB3_ENST00000440870.3_RNA|PRB3_ENST00000279573.6_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGGGGTGGTCCTTCTGGCTTT	0.632000													30	400					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37486341	37486341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37486341C>T	ENST00000374660.1	+	35	2937	c.2838C>T	c.(2836-2838)gcC>gcT	p.A946A	ANKRD30A_ENST00000361713.1_Silent_p.A827A|ANKRD30A_ENST00000602533.1_Silent_p.A827A			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	997						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TTTAGCCTGCCATTGAAATGC	0.308000													37	104					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202538	56202538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56202538C>T	ENST00000361673.3	-	5	5094	c.4881G>A	c.(4879-4881)atG>atA	p.M1627I		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1627							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TAGGTTCCTCCATTTTGTGGC	0.458000													24	86					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200971323	200971323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200971323C>T	ENST00000332129.2	-	9	1684	c.1368G>A	c.(1366-1368)atG>atA	p.M456I	KIF21B_ENST00000360529.5_Missense_Mutation_p.M456I|KIF21B_ENST00000461742.2_Missense_Mutation_p.M456I|KIF21B_ENST00000422435.2_Missense_Mutation_p.M456I	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	456					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CCTCCTGGCTCATGAGCTGGG	0.627000													27	58					0	0	1	0	0
TMPO	7112	broad.mit.edu	37	12	98941610	98941610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:98941610C>T	ENST00000556029.1	+	9	1695	c.1339C>T	c.(1339-1341)Cat>Tat	p.H447Y	TMPO_ENST00000393053.2_Missense_Mutation_p.H338Y|TMPO_ENST00000343315.5_Missense_Mutation_p.H407Y|TMPO_ENST00000548223.1_3'UTR	NM_001032283.2	NP_001027454.1	P42167	LAP2B_HUMAN	thymopoietin	447						integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TAATTTTCTTCATGTTGACCC	0.343000													51	115					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70956739	70956739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70956739G>A	ENST00000334414.6	-	16	4097	c.4053C>T	c.(4051-4053)gaC>gaT	p.D1351D	PTPRB_ENST00000550358.1_Silent_p.D1263D|PTPRB_ENST00000551525.1_Silent_p.D1350D|PTPRB_ENST00000261266.5_Silent_p.D1133D|PTPRB_ENST00000451516.2_Silent_p.D1043D|PTPRB_ENST00000538708.1_Silent_p.D1043D|PTPRB_ENST00000550857.1_Silent_p.D1043D	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1133	Fibronectin type-III 15.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGACTAGTGGGTCAACTTGAG	0.498000													17	75					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98189325	98189325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98189325G>A	ENST00000332650.5	+	1	1002	c.905G>A	c.(904-906)aGa>aAa	p.R302K		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGTGTCTTAAGAAAAATTCTG	0.294000													14	46					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111748289	111748289	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111748289A>T	ENST00000261726.6	+	15	1857	c.1703A>T	c.(1702-1704)aAa>aTa	p.K568I		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	568						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CAGCTGCTGAAACACAACATC	0.687000													35	80					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987912	50987912	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50987912C>T	ENST00000395676.2	+	1	1451	c.1317C>T	c.(1315-1317)ttC>ttT	p.F439F		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	439										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGGCACCTTCCCTGTGGCCC	0.652000													28	85					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11706749	11706749	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11706749T>C	ENST00000381486.2	+	4	721	c.421T>C	c.(421-423)Ttg>Ctg	p.L141L	GREB1_ENST00000263834.5_Silent_p.L141L|GREB1_ENST00000234142.5_Silent_p.L141L|GREB1_ENST00000389825.3_Silent_p.L31L|GREB1_ENST00000381483.2_Silent_p.L141L	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	141						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CAAGAGGTTCTTGCCAGATGA	0.577000													42	105					0	0	1	0	0
SLC16A11	162515	broad.mit.edu	37	17	6945458	6945458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6945458G>A	ENST00000308009.1	-	3	1380	c.1043C>T	c.(1042-1044)gCc>gTc	p.A348V	SLC16A11_ENST00000447225.1_Missense_Mutation_p.A316V	NM_153357.1	NP_699188.1	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	348						integral to membrane|plasma membrane	symporter activity			endometrium(2)|kidney(2)|lung(2)|ovary(1)|skin(2)	9						CAGCCCATAGGCCACAGCCGC	0.716000													7	5					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167786700	167786700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:167786700C>T	ENST00000397829.4	-	8	1105	c.938G>A	c.(937-939)gGa>gAa	p.G313E	TCP10_ENST00000366827.2_Intron	NM_004610.3	NP_004601.3	Q12799	TCP10_HUMAN	t-complex 10	340						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		GTGCAGAGCTCCTGGAAATTC	0.527000													12	92					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72667227	72667227	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72667227G>A	ENST00000261180.4	+	1	765	c.669G>A	c.(667-669)agG>agA	p.R223R	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	223					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TGCTGAATAGGACACTGGACG	0.557000													17	84					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27361019	27361019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27361019G>A	ENST00000335524.3	-	3	704	c.179C>T	c.(178-180)tCc>tTc	p.S60F		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	60	Pro-rich.									cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGAGGGGAGGAGGGACGACG	0.572000													7	28					0	0	1	0	0
SRSF11	9295	broad.mit.edu	37	1	70716379	70716379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70716379C>T	ENST00000370950.3	+	13	1428	c.1346C>T	c.(1345-1347)tCc>tTc	p.S449F	SRSF11_ENST00000370949.1_Missense_Mutation_p.S389F|SRSF11_ENST00000405432.1_Missense_Mutation_p.S449F|SRSF11_ENST00000370951.1_Missense_Mutation_p.S448F|SRSF11_ENST00000484162.1_3'UTR			Q05519	SRS11_HUMAN	serine/arginine-rich splicing factor 11	449					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			large_intestine(3)|ovary(2)|skin(1)	6						GAAACAGGTTCCCCTAAAACA	0.408000													11	69					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6711196	6711196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6711196C>T	ENST00000245907.6	-	12	1373	c.1281G>A	c.(1279-1281)aaG>aaA	p.K427K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	427					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GCTCCTGCTTCTTCGTGCGCA	0.607000													12	51					0	0	1	0	0
MSGN1	343930	broad.mit.edu	37	2	17997965	17997965	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:17997965C>T	ENST00000281047.3	+	1	203	c.180C>T	c.(178-180)ccC>ccT	p.P60P		NM_001105569.1	NP_001099039.1	A6NI15	MSGN1_HUMAN	mesogenin 1	60					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTTCTTCTCCCTGTCCAGCTG	0.657000													8	90					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56481389	56481389	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56481389G>A	ENST00000370765.6	-	24	6983	c.6876C>T	c.(6874-6876)ttC>ttT	p.F2292F	DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000244364.6_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1630					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGGGATTAGGGAAAACTCTTG	0.423000													39	88					0	0	1	0	0
TRGV8	6982	broad.mit.edu	37	7	38370508	38370508	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38370508G>A	ENST00000390343.2	-	0	28																											ACTCAACAAGGAAGTGATCCC	0.512000													9	24					0	0	1	0	0
IL20	50604	broad.mit.edu	37	1	207041867	207041867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207041867G>A	ENST00000367098.1	+	6	852	c.489G>A	c.(487-489)ggG>ggA	p.G163G	IL20_ENST00000367096.3_Silent_p.G163G|IL20_ENST00000391930.2_Silent_p.G138G			Q9NYY1	IL20_HUMAN	interleukin 20	163					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding			endometrium(2)|large_intestine(3)|lung(2)|pancreas(1)|urinary_tract(1)	9	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		AGGCTTTGGGGGAACTAGACA	0.473000													7	22					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46263989	46263989	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46263989G>A	ENST00000510861.1	-	9	1186	c.1013C>T	c.(1012-1014)aCc>aTc	p.T338I	GABRA2_ENST00000381620.4_Missense_Mutation_p.T338I|GABRA2_ENST00000507069.1_Missense_Mutation_p.T338I|GABRA2_ENST00000356504.1_Missense_Mutation_p.T338I|GABRA2_ENST00000514090.1_Missense_Mutation_p.T338I|GABRA2_ENST00000515082.1_Missense_Mutation_p.T338I|GABRA2_ENST00000540012.1_Missense_Mutation_p.T283I			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	338					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCCTCTTTTGGTGAAGTAATT	0.398000													34	108					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55838615	55838615	+	Missense_Mutation	SNP	G	G	A	rs79362849		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:55838615G>A	ENST00000302000.6	-	3	960	c.866C>T	c.(865-867)tCa>tTa	p.S289L	PYGO1_ENST00000563719.1_Missense_Mutation_p.S289L	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	289	Asn-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		AGTGCTACTTGAACGGCTGTT	0.423000													69	347					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47608979	47608979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47608979G>A	ENST00000371891.3	+	5	580	c.549G>A	c.(547-549)ctG>ctA	p.L183L	CYP4A22_ENST00000371890.3_Silent_p.L183L|CYP4A22_ENST00000294337.3_Silent_p.L183L|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000485117.1_3'UTR	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	183						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATTCCCCTCTGGAGGTCTTTC	0.547000													25	63					0	0	1	0	0
SLC5A3	6526	broad.mit.edu	37	21	35469468	35469468	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:35469468C>T	ENST00000381151.3	+	2	2483	c.1971C>T	c.(1969-1971)ttC>ttT	p.F657F	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	657						integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						ACTGGAAGTTCATAGACTGGT	0.463000													11	135					0	0	1	0	0
TIAL1	7073	broad.mit.edu	37	10	121336989	121336989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:121336989G>A	ENST00000369092.4	-	10	1650	c.342C>T	c.(340-342)ttC>ttT	p.F114F	TIAL1_ENST00000369093.2_Silent_p.F254F|TIAL1_ENST00000436547.2_Silent_p.F237F			Q01085	TIAR_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein-like 1	237	RRM 2.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(3)|ovary(1)	13		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		CCTTTTCTGGGAAAACTCTTA	0.318000													28	48					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81969958	81969958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81969958G>A	ENST00000359376.3	+	27	3241	c.3027G>A	c.(3025-3027)atG>atA	p.M1009I		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	1009	PI-PLC Y-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						GTTCTCAGATGGTGGCACTCA	0.567000													18	62					0	0	1	0	0
NEXN	91624	broad.mit.edu	37	1	78383885	78383885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:78383885G>A	ENST00000330010.8	+	4	479	c.182G>A	c.(181-183)cGa>cAa	p.R61Q	NEXN_ENST00000334785.7_Missense_Mutation_p.R125Q|NEXN_ENST00000457030.1_Missense_Mutation_p.R125Q|NEXN_ENST00000294624.8_Missense_Mutation_p.R125Q	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	125	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		GAGGAGGAACGAAAACGCAGA	0.363000													35	83					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154862651	154862651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:154862651C>T	ENST00000287907.2	+	1	618	c.42C>T	c.(40-42)acC>acT	p.T14T	AC093726.4_ENST00000493904.1_Intron|AC093726.4_ENST00000395731.2_Intron|AC093726.4_ENST00000543018.1_Intron	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	14						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CCCTCTCCACCCCCTCCCCTT	0.587000													49	131					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131519752	131519752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131519752C>T	ENST00000423981.1	+	2	217	c.107C>T	c.(106-108)cCc>cTc	p.P36L	AMER3_ENST00000321420.4_Missense_Mutation_p.P36L	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GGGACAGGCCCCTGGTCAGTC	0.622000													3	10					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46825075	46825075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46825075C>T	ENST00000339613.2	+	10	1274	c.1019C>T	c.(1018-1020)tCc>tTc	p.S340F	AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000300862.3_Missense_Mutation_p.S394F|HIF3A_ENST00000244303.6_Missense_Mutation_p.S327F|HIF3A_ENST00000420102.2_Missense_Mutation_p.S345F|HIF3A_ENST00000377670.4_Missense_Mutation_p.S396F|HIF3A_ENST00000472815.1_Missense_Mutation_p.S327F|HIF3A_ENST00000600383.1_Missense_Mutation_p.S327F			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CACCCGCCTTCCCTGAGCGAG	0.687000													21	101					0	0	1	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420022	56420022	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:56420022G>A	ENST00000407595.2	+	2	1189	c.687G>A	c.(685-687)gcG>gcA	p.A229A	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	229	His-rich.									breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AGCACCACGCGAGCAGTGGCA	0.682000													20	45					0	0	1	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79629673	79629673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:79629673C>T	ENST00000263849.4	+	9	1025	c.923C>T	c.(922-924)cCt>cTt	p.P308L		NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	308																	ACTAAATACCCTGTAGAATGG	0.368000													59	132					0	0	1	0	0
NDUFA9	4704	broad.mit.edu	37	12	4796131	4796131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4796131C>T	ENST00000266544.5	+	11	1011	c.991C>T	c.(991-993)Cac>Tac	p.H331Y	NDUFA9_ENST00000540688.1_Missense_Mutation_p.H90Y|RP11-234B24.6_ENST00000544741.2_Intron	NM_005002.4	NP_004993.1	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	331					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21					NADH(DB00157)	GAAATTGCCTCACCTGCCTGG	0.502000													15	33					0	0	1	0	0
ERRFI1	54206	broad.mit.edu	37	1	8073739	8073739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8073739G>A	ENST00000377482.5	-	4	1143	c.920C>T	c.(919-921)tCg>tTg	p.S307L	ERRFI1_ENST00000474874.1_Intron|ERRFI1_ENST00000467067.1_3'UTR	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	307					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		ATAGGTGCTCGAAGTAACTTC	0.507000													58	137					0	0	1	0	0
TUBG1	7283	broad.mit.edu	37	17	40766576	40766576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40766576C>T	ENST00000251413.3	+	10	1121	c.1059C>T	c.(1057-1059)ccC>ccT	p.P353P		NM_001070.4	NP_001061.2	P23258	TBG1_HUMAN	tubulin, gamma 1	353					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		CGTGGGGCCCCGCCAGCATCC	0.652000													40	40					0	0	1	0	0
RASD2	23551	broad.mit.edu	37	22	35947969	35947969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:35947969G>A	ENST00000216127.4	+	3	1333	c.691G>A	c.(691-693)Gtc>Atc	p.V231I		NM_014310.3	NP_055125.2	Q96D21	RHES_HUMAN	RASD family, member 2	231	Interaction with GNB1, GNB2 and GNB3.				locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	13						CTATGGCATGGTCTCGCCCTT	0.647000													18	53					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102709863	102709863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102709863C>T	ENST00000299855.5	-	7	1303	c.1047G>A	c.(1045-1047)aaG>aaA	p.K349K		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	349	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	AAACGAGGTCCTTGCTAGTAA	0.373000													52	74					0	0	1	0	0
ADD3	120	broad.mit.edu	37	10	111872536	111872536	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:111872536C>T	ENST00000277900.8	+	3	562	c.195_splice	c.e3-1	p.A66_splice	ADD3_ENST00000360162.3_Splice_Site_p.A66_splice|ADD3_ENST00000356080.4_Splice_Site_p.A66_splice|ADD3_ENST00000497125.1_3'UTR	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	66						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GTATTACAGGCCTTTCGGGAA	0.403000													33	92					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48745180	48745180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48745180G>A	ENST00000427699.1	+	12	1777	c.1697G>A	c.(1696-1698)aGg>aAg	p.R566K	ABCC3_ENST00000285238.8_Intron	NM_001144070.1	NP_001137542.1	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	0	ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GGCATGGCCAGGGCTCATTGG	0.622000													7	24					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113286461	113286461	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113286461C>T	ENST00000264852.4	+	3	1145	c.419C>T	c.(418-420)cCc>cTc	p.P140L	SIDT1_ENST00000393830.3_Missense_Mutation_p.P140L	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	140						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						GAGACGGGACCCTTGCAGCAA	0.493000													50	153					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111109730	111109730	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111109730C>T	ENST00000360467.5	+	21	1686	c.1380C>T	c.(1378-1380)ggC>ggT	p.G460G	COL4A2-AS2_ENST00000458403.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	460	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GAAGAGCAGGCTTCCCTGGGC	0.617000													11	42					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11468641	11468641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:11468641G>A	ENST00000423059.3	-	14	3427	c.3176C>T	c.(3175-3177)tCt>tTt	p.S1059F	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1059	TSP type-1 11.					integral to membrane		p.S1059F(1)		NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CAGCCATTTAGAACGAACCTT	0.507000										HNSCC(18;0.044)			97	284					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73065742	73065742	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73065742C>T	ENST00000429829.1	-	0	6846					NR_001564.2																						GAAAAGGGGCCTTGGTGATCA	0.512000													49	45					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13612089	13612089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13612089C>T	ENST00000404922.3	+	2	353	c.234C>T	c.(232-234)ttC>ttT	p.F78F	FBLN2_ENST00000535798.1_Silent_p.F104F|FBLN2_ENST00000492059.1_Silent_p.F78F|FBLN2_ENST00000295760.7_Silent_p.F78F	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	78	N.|Subdomain NA (Cys-rich).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGGGTGGCTTCGTGCGCGGCC	0.657000													3	7					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30433000	30433000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30433000G>A	ENST00000375978.3	-	1	420	c.346C>T	c.(346-348)Cgg>Tgg	p.R116W		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	116					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CCTGTCTGCCGGGTGAAGCGG	0.706000													10	32					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17743770	17743770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:17743770G>A	ENST00000380060.3	+	6	1819	c.1481G>A	c.(1480-1482)gGg>gAg	p.G494E	NHS_ENST00000398097.3_Missense_Mutation_p.G338E	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	494						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					AATAGAGGTGGGGATGCTGAG	0.512000													22	42					0	0	1	0	0
OR7C1	26664	broad.mit.edu	37	19	14910058	14910058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14910058C>T	ENST00000248073.2	-	1	965	c.891G>A	c.(889-891)atG>atA	p.M297I	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	297					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						GGGCCCTCTTCATGTCCGTGT	0.522000													43	96					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44131741	44131741	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44131741C>T	ENST00000262726.7	-	7	893	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	EFCAB6_ENST00000358439.4_Missense_Mutation_p.E108K|EFCAB6_ENST00000356087.4_Missense_Mutation_p.E108K|EFCAB6_ENST00000396231.2_Missense_Mutation_p.E62K	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GCTTACTTTTCGTATTCCTCG	0.443000													41	107					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494093	55494093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55494093G>A	ENST00000543010.1	+	6	1170	c.1027G>A	c.(1027-1029)Gac>Aac	p.D343N	NLRP2_ENST00000339757.7_Missense_Mutation_p.D321N|NLRP2_ENST00000391721.4_Missense_Mutation_p.D319N|NLRP2_ENST00000427260.2_Missense_Mutation_p.D320N|NLRP2_ENST00000538819.1_Missense_Mutation_p.D319N|NLRP2_ENST00000263437.6_Missense_Mutation_p.D340N|NLRP2_ENST00000537859.1_Missense_Mutation_p.D321N|NLRP2_ENST00000448584.2_Missense_Mutation_p.D343N	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	343	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGCCCTGAGGGACCTCCGGAT	0.627000													13	15					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347554	91347554	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91347554G>A	ENST00000358859.2	-	1	1399	c.966C>T	c.(964-966)gtC>gtT	p.V322V	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		cagcctcttcgacctcttctt	0.557000													9	31					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25257389	25257389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25257389G>A	ENST00000354454.3	+	19	1970	c.1141G>A	c.(1141-1143)Gaa>Aaa	p.E381K	LRMP_ENST00000548766.1_Missense_Mutation_p.E381K|LRMP_ENST00000547044.1_Missense_Mutation_p.E381K	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	437					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					AGAAAAATGTGAACTAAAGTA	0.403000													7	41					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70501234	70501234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70501234G>A	ENST00000260128.4	+	8	1309	c.592G>A	c.(592-594)Gag>Aag	p.E198K	SULF1_ENST00000419716.3_Missense_Mutation_p.E198K|SULF1_ENST00000458141.2_Missense_Mutation_p.E198K|SULF1_ENST00000402687.4_Missense_Mutation_p.E198K	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	198					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding	p.E198K(1)		breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AATCACTAACGAGAGCATTAA	0.428000													18	73					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112693694	112693694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112693694G>A	ENST00000471858.1	-	1	243	c.11C>T	c.(10-12)cCt>cTt	p.P4L	CD200R1_ENST00000308611.3_Missense_Mutation_p.P4L|CD200R1_ENST00000440122.2_Missense_Mutation_p.P4L|CD200R1_ENST00000295863.4_Missense_Mutation_p.P4L|CD200R1_ENST00000490004.1_Missense_Mutation_p.P4L	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	4					interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						AGTTCTCCAAGGGCAGAGCAT	0.463000													9	48					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77282723	77282723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77282723G>A	ENST00000376896.2	+	8	1629	c.1017G>A	c.(1015-1017)gtG>gtA	p.V339V	RORB_ENST00000396204.2_Silent_p.V350V	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	350	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.V339V(1)		breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						ATGACCTAGTGAATGAAGCAT	0.383000													33	72					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14287146	14287146	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:14287146G>A	ENST00000310358.7	+	0	2872				RP11-21L19.1_ENST00000534587.1_RNA			Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AACGTTACATGACTGTAAAGA	0.473000													15	20					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76490701	76490701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76490701G>A	ENST00000389840.5	-	40	6326	c.6202C>T	c.(6202-6204)Cgg>Tgg	p.R2068W	RP11-559N14.5_ENST00000591373.1_RNA|DNAH17_ENST00000585328.1_Missense_Mutation_p.R2077W					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCCGTTTCCGAGGCACGTCC	0.592000													40	139					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345121	20345121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20345121G>A	ENST00000298642.2	+	1	731	c.695G>A	c.(694-696)gGa>gAa	p.G232E		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTCCAGAGGATCATCTAAG	0.383000													56	142					0	0	1	0	0
TTLL2	83887	broad.mit.edu	37	6	167754787	167754787	+	Missense_Mutation	SNP	G	G	A	rs140708449		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:167754787G>A	ENST00000239587.5	+	3	1487	c.1399G>A	c.(1399-1401)Gag>Aag	p.E467K		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	467					protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		AATGTACAACGAGGATGACTC	0.498000													33	50					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43822140	43822140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43822140C>T	ENST00000389420.3	-	26	3848	c.3849G>A	c.(3847-3849)acG>acA	p.T1283T	ADAMTS20_ENST00000395541.2_Silent_p.T401T|ADAMTS20_ENST00000553158.1_Silent_p.T1283T	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1283						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ATGGCAAATTCGTGCTTAGAT	0.483000													14	50					0	0	1	0	0
LRRC23	10233	broad.mit.edu	37	12	7014914	7014914	+	Silent	SNP	C	C	T	rs116430099	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7014914C>T	ENST00000007969.8	+	2	337	c.117C>T	c.(115-117)ttC>ttT	p.F39F	LRRC23_ENST00000449039.1_3'UTR|LRRC23_ENST00000429740.1_Silent_p.F39F|LRRC23_ENST00000443597.2_Silent_p.F39F|LRRC23_ENST00000436789.1_Silent_p.F39F|LRRC23_ENST00000433346.1_Silent_p.F39F|LRRC23_ENST00000323702.5_Silent_p.F39F	NM_001135217.1|NM_201650.2	NP_001128689.1|NP_964013.1	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	39										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						gggaagagTTCCCTGAGGAAG	0.557000													20	51					0	0	1	0	0
TNFSF18	8995	broad.mit.edu	37	1	173013100	173013100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173013100C>T	ENST00000404377.3	-	2	232	c.232G>A	c.(232-234)Gag>Aag	p.E78K	RP1-15D23.2_ENST00000432694.1_RNA|TNFSF18_ENST00000239468.2_Missense_Mutation_p.E56K	NM_005092.3	NP_005083.2	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily, member 18	78					anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	9						ATACAGGGCTCCTTAGCAGTC	0.353000													39	78					0	0	1	0	0
EHBP1	23301	broad.mit.edu	37	2	63085637	63085637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:63085637C>T	ENST00000263991.5	+	8	1213	c.731C>T	c.(730-732)tCc>tTc	p.S244F	EHBP1_ENST00000431489.1_Intron|EHBP1_ENST00000405289.1_Intron|EHBP1_ENST00000354487.3_Intron|EHBP1_ENST00000405015.3_Intron	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	244						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TCAGCCAGTTCCTCTGAAGGT	0.408000													12	56					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154379625	154379625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:154379625G>A	ENST00000406326.1	+	6	1296	c.893G>A	c.(892-894)gGa>gAa	p.G298E	DPP6_ENST00000404039.1_Intron|DPP6_ENST00000427557.1_Intron|DPP6_ENST00000377770.3_Intron|DPP6_ENST00000332007.3_Intron			P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	0					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGAGTCCCAGGAGGCAGGACT	0.572000													31	127					0	0	1	0	0
MIR1269A	100302177	broad.mit.edu	37	4	67142634	67142634	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:67142634C>T	ENST00000408636.1	+	0	93					NR_031673.1																						tactggcttccctggtctcca	0.517000													6	36					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93518142	93518142	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93518142A>T	ENST00000394196.4	+	20	3607	c.2539A>T	c.(2539-2541)Aaa>Taa	p.K847*	CHD2_ENST00000557381.1_Nonsense_Mutation_p.K847*	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	847	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AGAAATCCGAAAACAGGCACT	0.438000													27	90					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45821601	45821601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45821601C>T	ENST00000397928.1	+	16	2804	c.2359C>T	c.(2359-2361)Cgc>Tgc	p.R787C	TRPM2_ENST00000300481.9_Missense_Mutation_p.R767C|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.R787C|TRPM2_ENST00000397932.2_Missense_Mutation_p.R787C	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	787						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCCCGCGGCCCGCGCCCGTGC	0.652000													39	95					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23219402	23219402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23219402C>T	ENST00000400191.3	+	7	1472	c.1454C>T	c.(1453-1455)gCc>gTc	p.A485V	EPHB2_ENST00000374632.3_Missense_Mutation_p.A485V|EPHB2_ENST00000374630.3_Missense_Mutation_p.A485V|EPHB2_ENST00000374627.1_Missense_Mutation_p.A480V|EPHB2_ENST00000465676.1_3'UTR	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	485	Fibronectin type-III 2.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		AACGCCACAGCCATAAAAAGC	0.602000													26	53					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	20884243	20884243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20884243G>A	ENST00000382152.2	-	2	318	c.151C>T	c.(151-153)Cct>Tct	p.P51S	KCNIP4_ENST00000382149.4_Intron|KCNIP4_ENST00000509207.1_Intron|KCNIP4_ENST00000382148.3_Intron|KCNIP4_ENST00000447367.2_Intron|KCNIP4_ENST00000359001.5_Intron|KCNIP4_ENST00000382150.4_Intron	NM_025221.5	NP_079497.2	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	51						plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				TGAATAGCAGGAGACGACGTT	0.443000													7	53					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155646	151155646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151155646G>A	ENST00000282466.3	-	6	6702	c.6703C>T	c.(6703-6705)Cca>Tca	p.P2235S	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2235	Ig-like C2-type 9.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTGATTAATGGAGGTTTAGAG	0.433000													44	108					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75065478	75065478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75065478C>T	ENST00000326665.5	-	11	1845	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	C1orf173_ENST00000420661.2_Missense_Mutation_p.E346K|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	543	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GTTTCACTCTCTTTTTCAGGG	0.408000													53	225					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2796226	2796226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2796226C>T	ENST00000520002.1	-	71	11134	c.10579G>A	c.(10579-10581)Gaa>Aaa	p.E3527K	CSMD1_ENST00000542608.1_Missense_Mutation_p.E3349K|CSMD1_ENST00000400186.3_Missense_Mutation_p.E3350K|CSMD1_ENST00000602557.1_Missense_Mutation_p.E3527K|CSMD1_ENST00000537824.1_Missense_Mutation_p.E3526K|CSMD1_ENST00000602723.1_Missense_Mutation_p.E3350K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3527						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTGCTGTTTTCATGCCCAGCA	0.403000													3	14					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133984069	133984069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133984069G>A	ENST00000220616.4	+	33	6046	c.6006G>A	c.(6004-6006)gcG>gcA	p.A2002A	TG_ENST00000542445.1_Silent_p.A372A|TG_ENST00000519543.1_Silent_p.A156A|TG_ENST00000377869.1_Silent_p.A1945A	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2002					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGTGCGATGCGGACCCATGCT	0.493000													17	64					0	0	1	0	0
SCNN1D	6339	broad.mit.edu	37	1	1222349	1222349	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1222349C>T	ENST00000338555.2	+	5	1765	c.621C>T	c.(619-621)ttC>ttT	p.F207F	SCNN1D_ENST00000379116.5_Silent_p.F371F|SCNN1D_ENST00000400928.3_Silent_p.F207F|SCNN1D_ENST00000325425.8_Silent_p.F273F					sodium channel, non-voltage-gated 1, delta subunit											lung(6)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GAGTGGGGTTCAGACTGGTGA	0.706000													16	36					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23543653	23543653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23543653C>T	ENST00000300619.7	-	4	2333	c.2128G>A	c.(2128-2130)Gga>Aga	p.G710R	ZNF91_ENST00000397082.2_Missense_Mutation_p.G678R|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	710						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTTTCTCTCCAGCATGTATT	0.318000													13	71					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8720369	8720369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:8720369G>A	ENST00000359865.3	+	4	374	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	SOGA2_ENST00000306285.7_5'UTR|SOGA2_ENST00000306329.11_Missense_Mutation_p.E438K|SOGA2_ENST00000400050.3_Missense_Mutation_p.E78K|SOGA2_ENST00000517570.1_Missense_Mutation_p.E78K	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	429								p.E78K(1)									ATTGCACCACGAACTTAAGAC	0.463000													26	76					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42231185	42231185	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42231185G>A	ENST00000221992.6	+	9	2172	c.2058G>A	c.(2056-2058)ggG>ggA	p.G686G	CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000398599.4_Silent_p.G685G|CEACAM5_ENST00000405816.1_Silent_p.G686G	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	686						anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TCTCAGCTGGGGCCACTGTCG	0.483000													150	386					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121498412	121498412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121498412C>T	ENST00000260197.7	+	47	6642	c.6513C>T	c.(6511-6513)gcC>gcT	p.A2171A	SORL1_ENST00000527934.1_Silent_p.A786A|SORL1_ENST00000525532.1_Silent_p.A1115A|SORL1_ENST00000532694.1_Silent_p.A1017A|SORL1_ENST00000534286.1_Silent_p.A1081A	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2171					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GCTTCACCGCCTTCGCCAACA	0.607000													14	37					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122839956	122839956	+	Silent	SNP	G	G	A	rs145044274		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122839956G>A	ENST00000194130.2	-	1	84	c.45C>T	c.(43-45)ttC>ttT	p.F15F		NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	15						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TGAAAACCACGAAGAGAAATC	0.428000													16	48					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226496869	226496869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226496869G>A	ENST00000328205.5	-	1	565	c.20C>T	c.(19-21)cCt>cTt	p.P7L	LIN9_ENST00000366801.1_5'UTR|LIN9_ENST00000481685.1_Missense_Mutation_p.P7L	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	0	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		CTTTTTCAAAGGCTGCCCGCC	0.672000													22	42					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129123158	129123158	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129123158C>T	ENST00000505956.1	-	7	1500	c.1338G>A	c.(1336-1338)aaG>aaA	p.K446K	EFCAB12_ENST00000326085.3_Silent_p.K446K	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		GAGAAAAGACCTTCCAGTCAG	0.572000													38	87					0	0	1	0	0
RIBC2	26150	broad.mit.edu	37	22	45813553	45813553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45813553C>T	ENST00000342894.3	+	3	478	c.64C>T	c.(64-66)Ctc>Ttc	p.L22F	RIBC2_ENST00000538017.1_Missense_Mutation_p.L90F			Q9H4K1	RIBC2_HUMAN	RIB43A domain with coiled-coils 2	22										NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|skin(2)|urinary_tract(1)	10		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TAGGAAAAATCTCTGTAGGGC	0.433000													18	60					0	0	1	0	0
CKLF	51192	broad.mit.edu	37	16	66599833	66599833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66599833C>T	ENST00000264001.4	+	4	527	c.378C>T	c.(376-378)gcC>gcT	p.A126A	CKLF_ENST00000563092.1_3'UTR|CKLF_ENST00000351137.4_Silent_p.A73A|CKLF_ENST00000417030.2_Intron|CKLF_ENST00000362093.4_Silent_p.A41A|CKLF_ENST00000345436.4_Silent_p.A94A|CKLF_ENST00000532838.1_Intron|CKLF-CMTM1_ENST00000527729.1_Intron	NM_016951.3	NP_058647.1			chemokine-like factor											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|upper_aerodigestive_tract(1)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0689)|Epithelial(162;0.217)		CCGACGGGGCCCTTATTTACC	0.438000													28	114					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34646010	34646010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34646010C>T	ENST00000537011.1	+	5	1394	c.1012C>T	c.(1012-1014)Cct>Tct	p.P338S	NUTM1_ENST00000333756.4_Missense_Mutation_p.P310S|NUTM1_ENST00000438749.3_Missense_Mutation_p.P328S					NUT midline carcinoma, family member 1																		GGGCCTGTCTCCTGCAACCCC	0.552000													38	85					0	0	1	0	0
LINC00842	643650	broad.mit.edu	37	10	47133601	47133601	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:47133601G>A	ENST00000422732.2	-	0	435					NR_033957.1																						ccaccaccacgactgccacca	0.483000													13	82					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189864086	189864086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189864086C>T	ENST00000304636.3	+	30	2268	c.2098C>T	c.(2098-2100)Ccc>Tcc	p.P700S	COL3A1_ENST00000317840.5_Missense_Mutation_p.P700S	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	700	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGAGCTGGTCCCCCTGGTCC	0.478000													4	16					0	0	1	0	0
RD3	343035	broad.mit.edu	37	1	211654713	211654713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:211654713C>T	ENST00000367002.4	-	2	1208	c.45G>A	c.(43-45)cgG>cgA	p.R15R	RD3_ENST00000484910.1_Intron	NM_001164688.1|NM_183059.2	NP_001158160.1|NP_898882.1	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	15					response to stimulus|visual perception					central_nervous_system(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		TGGTGGACAGCCGGGATGGGG	0.622000													8	72					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5363817	5363817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5363817C>T	ENST00000300773.2	-	1	992	c.938G>A	c.(937-939)tGa>tAa	p.*313*	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTGGAGATCAGGTTCCAAT	0.383000													7	71					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513213	78513213	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:78513213C>T	ENST00000397909.2	+	15	3410	c.3237C>T	c.(3235-3237)atC>atT	p.I1079I	NAV3_ENST00000228327.6_Silent_p.I1079I|NAV3_ENST00000536525.2_Silent_p.I1079I|NAV3_ENST00000266692.7_Silent_p.I1079I			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1079	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CTGCCATGATCACCAGCAGTG	0.498000										HNSCC(70;0.22)			6	72					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183888435	183888435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183888435C>T	ENST00000313143.3	+	15	2291	c.2043C>T	c.(2041-2043)gcC>gcT	p.A681A	EIF2B5_ENST00000444495.1_Intron|DVL3_ENST00000431765.1_Silent_p.A664A	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	681					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CCCCAGGAGCCCCTCCGGGCC	0.697000													15	19					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768756	117768756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117768756G>A	ENST00000317775.6	-	2	804	c.119C>T	c.(118-120)cCc>cTc	p.P40L	NOS1_ENST00000344089.3_Missense_Mutation_p.P40L|NOS1_ENST00000338101.4_Missense_Mutation_p.P40L	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	40	Interaction with NOSIP (By similarity).|PDZ.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GATGATCACGGGCGGCTTACT	0.587000													15	78					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1272354	1272354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1272354G>A	ENST00000310581.5	-	7	2385	c.2328C>T	c.(2326-2328)ttC>ttT	p.F776F	TERT_ENST00000296820.5_Intron|TERT_ENST00000508104.2_Intron|TERT_ENST00000334602.6_Silent_p.F776F	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	776	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGTGAGCCACGAACTGTCGCA	0.657000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				6	16					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135862086	135862086	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135862086G>A	ENST00000339463.3	+	6	840	c.21G>A	c.(19-21)gtG>gtA	p.V7V	GFI1B_ENST00000372122.1_Silent_p.V7V|GFI1B_ENST00000534944.1_Silent_p.V7V|GFI1B_ENST00000450530.1_Silent_p.V7V|GFI1B_ENST00000372124.1_Silent_p.V7V|GFI1B_ENST00000372123.1_Silent_p.V7V			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	7	Mediates repression of transcription.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		CCTTCCTGGTGAAGAGCAAGA	0.602000													7	20					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565172	20565172	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20565172C>T	ENST00000329697.6	-	5	835	c.667G>A	c.(667-669)Ggg>Agg	p.G223R	ACSM2B_ENST00000565322.1_Missense_Mutation_p.G144R|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G223R|ACSM2B_ENST00000565232.1_Missense_Mutation_p.G223R	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	223					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CCACTGGTCCCACTAGTGAAG	0.507000													16	85					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15931994	15931994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15931994G>A	ENST00000338282.6	-	2	222	c.116C>T	c.(115-117)cCc>cTc	p.P39L	MYH11_ENST00000576790.1_Missense_Mutation_p.P39L|MYH11_ENST00000396324.3_Missense_Mutation_p.P39L|MYH11_ENST00000452625.2_Missense_Mutation_p.P39L|MYH11_ENST00000300036.5_Missense_Mutation_p.P39L	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	39	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTTCTCCGAGGGGACCCAGAC	0.572000			T	CBFB	AML								23	142					0	0	1	0	0
SLC25A21	89874	broad.mit.edu	37	14	37180580	37180580	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:37180580G>A	ENST00000331299.5	-	7	1061	c.546C>T	c.(544-546)ttC>ttT	p.F182F	SLC25A21_ENST00000555449.1_Silent_p.F182F	NM_030631.3	NP_085134.1	Q9BQT8	ODC_HUMAN	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	182					lysine catabolic process	integral to membrane|mitochondrial inner membrane	alpha-ketoglutarate transmembrane transporter activity|binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|pancreas(1)|prostate(1)|skin(1)	9	Esophageal squamous(585;0.164)|Breast(36;0.179)|Hepatocellular(127;0.213)		Lung(8;2.16e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.0112)|all cancers(34;0.0274)|LUSC - Lung squamous cell carcinoma(13;0.149)	GBM - Glioblastoma multiforme(112;0.00204)		AAACCATGTTGAAAACTCCAT	0.383000													27	59					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13182884	13182884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13182884G>A	ENST00000379350.1	+	6	759	c.630G>A	c.(628-630)gaG>gaA	p.E210E	PHACTR1_ENST00000457702.2_Silent_p.E65E|PHACTR1_ENST00000379345.2_Silent_p.E65E|PHACTR1_ENST00000332995.7_Silent_p.E210E			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	210						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GCTCATATGAGGTGCTCCAAC	0.592000													7	94					0	0	1	0	0
SACM1L	22908	broad.mit.edu	37	3	45773594	45773594	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45773594C>T	ENST00000389061.5	+	13	1255	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	SACM1L_ENST00000541314.1_Nonsense_Mutation_p.R290*|SACM1L_ENST00000418611.1_Nonsense_Mutation_p.R248*	NM_014016.3	NP_054735.3	Q9NTJ5	SAC1_HUMAN	SAC1 suppressor of actin mutations 1-like (yeast)	351	SAC.					Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		GAGATGGGATCGACTAAGTAT	0.338000													47	133					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32370911	32370911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32370911G>A	ENST00000454136.3	-	3	514	c.510C>T	c.(508-510)ttC>ttT	p.F170F	BTNL2_ENST00000544175.1_Intron|BTNL2_ENST00000429232.2_Intron|BTNL2_ENST00000414363.1_Intron|BTNL2_ENST00000374993.1_Silent_p.F170F|BTNL2_ENST00000374995.3_Intron|BTNL2_ENST00000540315.1_Intron			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	170	Ig-like V-type 2.					integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						GGGGCTCTGGGAACCAGCCCC	0.592000													6	29					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024773	76024773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76024773C>T	ENST00000393004.2	-	5	996	c.775G>A	c.(775-777)Gaa>Aaa	p.E259K	FILIP1_ENST00000237172.7_Missense_Mutation_p.E259K|FILIP1_ENST00000370020.1_Missense_Mutation_p.E160K|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	259										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CCAAGTTGTTCAATGTGCATT	0.398000													58	105					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132207802	132207802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:132207802G>A	ENST00000360971.2	+	24	2565	c.2545G>A	c.(2545-2547)Gaa>Aaa	p.E849K		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	849	Nuclease.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTTGCACTGTGAAAACCTAGA	0.378000													28	40					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037470	75037470	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75037470C>T	ENST00000326665.5	-	14	4142	c.3924G>A	c.(3922-3924)gcG>gcA	p.A1308A	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1308	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TGTCCTGCATCGCTTCTGTCT	0.542000													68	144					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85266876	85266876	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:85266876A>T	ENST00000266682.5	-	7	1640	c.1099T>A	c.(1099-1101)Tgc>Agc	p.C367S	SLC6A15_ENST00000309283.7_Missense_Mutation_p.C75S|SLC6A15_ENST00000551388.1_5'UTR|SLC6A15_ENST00000552192.1_Missense_Mutation_p.C260S	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	367					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						TGTGTAATGCATTTCTCATTT	0.318000													23	67					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72049908	72049908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:72049908C>T	ENST00000305425.4	-	9	2372	c.1950G>A	c.(1948-1950)acG>acA	p.T650T	DACH1_ENST00000359684.2_Silent_p.T702T|DACH1_ENST00000313174.7_Silent_p.T502T|DACH1_ENST00000354591.4_Silent_p.T448T	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	700	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CACGCCGTTTCGTCTCAAACT	0.388000													84	196					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176946947	176946947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:176946947C>T	ENST00000308618.4	-	2	794	c.658G>A	c.(658-660)Gag>Aag	p.E220K		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	220						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GCGGCCAGCTCGCACCGGCGG	0.632000													8	25					0	0	1	0	0
A4GALT	53947	broad.mit.edu	37	22	43089886	43089886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43089886G>A	ENST00000401850.1	-	2	561	c.72C>T	c.(70-72)ttC>ttT	p.F24F	A4GALT_ENST00000249005.2_Silent_p.F24F|A4GALT_ENST00000381278.3_Silent_p.F24F			Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	24					glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			NS(1)|central_nervous_system(2)|large_intestine(6)|skin(1)|urinary_tract(1)	11						AGCCGATGATGAACAGGGTGC	0.597000													10	18					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112020	57112020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57112020G>A	ENST00000454682.1	-	3	3575	c.3294C>T	c.(3292-3294)tcC>tcT	p.S1098S	NACA_ENST00000548563.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CCCCTTTGGGGGATGGGGTAG	0.662000			T	BCL6	NHL								20	53					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36224722	36224722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36224722C>T	ENST00000420124.1	+	30	7108	c.7108C>T	c.(7108-7110)Ccc>Tcc	p.P2370S	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Missense_Mutation_p.P2370S																							TCCCCAGGTCCCCGATGGTCC	0.637000													19	40					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127379289	127379289	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127379289C>T	ENST00000342480.6	+	3	457	c.418C>T	c.(418-420)Cca>Tca	p.P140S		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	140					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						TCAAGAGCTGCCAAACCTCCC	0.498000													13	64					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50094243	50094243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50094243C>T	ENST00000376042.1	+	12	4262	c.3964C>T	c.(3964-3966)Ccc>Tcc	p.P1322S	CCNB3_ENST00000348603.2_Missense_Mutation_p.P218S|CCNB3_ENST00000276014.7_Missense_Mutation_p.P1322S|CCNB3_ENST00000376038.1_Missense_Mutation_p.P218S			Q8WWL7	CCNB3_HUMAN	cyclin B3	1322					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CTTCCAGGTTCCCTTCCTGGA	0.458000													62	37					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2718585	2718585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:2718585G>A	ENST00000382082.3	+	1	1084	c.846G>A	c.(844-846)gtG>gtA	p.V282V		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	282						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		TCAACACCGTGGAGGAGATGC	0.672000													3	16					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800647	21800647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21800647C>T	ENST00000443632.2	+	2	1835	c.1463C>T	c.(1462-1464)gCc>gTc	p.A488V	HIC2_ENST00000407598.2_Missense_Mutation_p.A488V|HIC2_ENST00000407464.2_Missense_Mutation_p.A488V			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	488					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GAGGAGGAGGCCGAGGACCTG	0.642000													11	43					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7618552	7618552	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7618552G>A	ENST00000256861.6	-	10	1920	c.1842C>T	c.(1840-1842)ttC>ttT	p.F614F	ITIH5_ENST00000298441.6_Silent_p.F400F|ITIH5_ENST00000446830.2_Silent_p.F396F|ITIH5_ENST00000397146.2_Silent_p.F614F|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Silent_p.F614F	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	614					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						AGGGAGTGAGGAAGCGGTAGC	0.667000													20	53					0	0	1	0	0
CNN3	1266	broad.mit.edu	37	1	95363566	95363566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:95363566G>A	ENST00000370206.4	-	7	1105	c.722C>T	c.(721-723)tCg>tTg	p.S241L	CNN3_ENST00000487539.1_5'UTR|CNN3_ENST00000545882.1_Missense_Mutation_p.S200L|CNN3_ENST00000538964.1_Missense_Mutation_p.S241L|CNN3_ENST00000394202.4_Missense_Mutation_p.S195L	NM_001839.3	NP_001830.1	Q15417	CNN3_HUMAN	calponin 3, acidic	241					actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|stomach(1)|urinary_tract(2)	18		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		GGAAATTGTCGAGTTGTCCAC	0.443000													45	126					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3424212	3424212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3424212C>T	ENST00000336727.3	+	11	3852	c.2948C>T	c.(2947-2949)tCc>tTc	p.S983F	RGS12_ENST00000538395.1_Missense_Mutation_p.S325F|RGS12_ENST00000344733.5_Missense_Mutation_p.S983F|RGS12_ENST00000306648.7_Missense_Mutation_p.S381F|RGS12_ENST00000338806.4_Missense_Mutation_p.S335F|RGS12_ENST00000382788.3_Missense_Mutation_p.S983F|RGS12_ENST00000508158.1_3'UTR	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	983	RBD 1.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCGGGCTTCTCCATCAAAGAC	0.632000													14	41					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4693861	4693861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4693861C>T	ENST00000354582.6	+	11	1260	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C	ITPR1_ENST00000456211.2_Missense_Mutation_p.R304C|ITPR1_ENST00000443694.2_Missense_Mutation_p.R304C|ITPR1_ENST00000423119.2_Missense_Mutation_p.R304C|ITPR1_ENST00000544951.1_Missense_Mutation_p.R304C|ITPR1_ENST00000357086.4_Missense_Mutation_p.R304C|ITPR1_ENST00000302640.8_Missense_Mutation_p.R304C			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	304	MIR 4.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CAGCCTTTTCCGTTTCAAGCA	0.522000													5	19					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22133973	22133973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22133973G>A	ENST00000408935.1	+	1	677	c.677G>A	c.(676-678)cGa>cAa	p.R226Q		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GTTTCTCTTCGAAAACACTCA	0.502000													30	60					0	0	1	0	0
OR7G1	125962	broad.mit.edu	37	19	9225552	9225552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9225552C>T	ENST00000293614.1	-	1	887	c.888G>A	c.(886-888)gaG>gaA	p.E296E	OR7G1_ENST00000541538.1_Silent_p.E296E			Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	20						CTTTCTTCATCTCCTTATTTC	0.413000													50	120					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111850537	111850537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:111850537G>A	ENST00000389811.4	+	18	1850	c.1626G>A	c.(1624-1626)agG>agA	p.R542R	ACOXL_ENST00000439055.1_Silent_p.R512R			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	542					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						CGAGGATCAGGAATCAGGTAA	0.458000													26	54					0	0	1	0	0
CD40LG	959	broad.mit.edu	37	X	135732492	135732492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135732492G>A	ENST00000370629.2	+	2	280	c.224G>A	c.(223-225)gGa>gAa	p.G75E	CD40LG_ENST00000370628.2_Missense_Mutation_p.G75E	NM_000074.2	NP_000065.1	P29965	CD40L_HUMAN	CD40 ligand	75					anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|skin(1)|stomach(1)	26	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	TGCAACACAGGAGAAAGATCC	0.343000									Immune Deficiency with Hyper-IgM				55	27					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72299376	72299376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72299376C>T	ENST00000263563.6	+	15	2034	c.1766C>T	c.(1765-1767)cCc>cTc	p.P589L		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		AGCGAGCCTCCCCCAGGCAAG	0.657000													19	50					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11631223	11631223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11631223C>T	ENST00000262442.3	+	28	5866	c.5798C>T	c.(5797-5799)tCa>tTa	p.S1933L	DNAH9_ENST00000454412.2_Missense_Mutation_p.S1933L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1933	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAGGTCTTGTCAGTGGTGGCA	0.493000													19	20					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374540	31374540	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31374540G>A	ENST00000268296.4	+	14	1676	c.1555G>A	c.(1555-1557)Ggt>Agt	p.G519S	ITGAX_ENST00000562522.1_Missense_Mutation_p.G519S	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	519					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CCACCCCTGGGGTCGCTTTGG	0.637000													56	100					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156230268	156230268	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156230268G>A	ENST00000361813.5	-	15	2401	c.2257C>T	c.(2257-2259)Cgg>Tgg	p.R753W	SMG5_ENST00000368267.4_Intron	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	753					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					AGCAGGGGCCGATCCGTGTCA	0.557000													16	142					0	0	1	0	0
MLLT1	4298	broad.mit.edu	37	19	6222145	6222145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6222145G>A	ENST00000252674.7	-	6	1260	c.1097C>T	c.(1096-1098)tCc>tTc	p.S366F		NM_005934.3	NP_005925.2	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	366					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						GGACTTGAAGGAGGCCTCGTC	0.642000			T	MLL	AL								7	22					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13538855	13538855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:13538855G>A	ENST00000341083.3	-	4	622	c.326C>T	c.(325-327)tCa>tTa	p.S109L	BEND7_ENST00000396898.2_Missense_Mutation_p.S174L|BEND7_ENST00000396900.2_Missense_Mutation_p.S161L|BEND7_ENST00000378605.3_Missense_Mutation_p.S122L	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	161							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						ACAGCAGTTTGATCCAGCTGA	0.378000													21	54					0	0	1	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152235965	152235965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152235965C>T	ENST00000243347.3	+	6	827	c.752C>T	c.(751-753)tCc>tTc	p.S251F		NM_007115.3	NP_009046.2	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	251					cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		GATCCTGTATCCAAATCCAGT	0.353000													36	123					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64746706	64746706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:64746706G>A	ENST00000543942.2	-	2	1009	c.383C>T	c.(382-384)cCa>cTa	p.P128L	RPS11P6_ENST00000535684.1_RNA|C12orf56_ENST00000333722.5_Missense_Mutation_p.P128L	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	128										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		ATGATGAAATGGAAATAGGAA	0.313000													15	46					0	0	1	0	0
HEXA	3073	broad.mit.edu	37	15	72638913	72638913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72638913G>A	ENST00000268097.5	-	11	1788	c.1285C>T	c.(1285-1287)Cct>Tct	p.P429S	RP11-106M3.3_ENST00000570175.1_RNA|HEXA_ENST00000567159.1_Missense_Mutation_p.P429S|RP11-106M3.2_ENST00000379915.4_RNA|HEXA_ENST00000457859.2_Intron|HEXA_ENST00000566304.1_Missense_Mutation_p.P440S|HEXA_ENST00000429918.2_Missense_Mutation_p.P256S	NM_000520.4	NP_000511.2	P06865	HEXA_HUMAN	hexosaminidase A (alpha polypeptide)	429					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(3)|kidney(3)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	24						TTCCAGTCAGGGCCATAGGAT	0.537000													111	206					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31907063	31907063	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31907063C>T	ENST00000456570.1	+	6	781	c.726C>T	c.(724-726)atC>atT	p.I242I	C2_ENST00000299367.5_Silent_p.I395I|C2_ENST00000452323.2_Silent_p.I181I|C2_ENST00000442278.2_Silent_p.I263I|C2_ENST00000469372.1_Silent_p.I149I|CFB_ENST00000477310.1_Silent_p.I213I|CFB_ENST00000556679.1_Silent_p.I242I			P00751	CFAB_HUMAN	complement factor B	408			I -> L (in AHUS4).		complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TCAGAGAGATCCTGAACATCA	0.463000													9	131					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124756397	124756397	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124756397G>A	ENST00000306534.3	-	16	3242	c.2757C>T	c.(2755-2757)ttC>ttT	p.F919F	ROBO4_ENST00000533054.1_Silent_p.F774F|RP11-664I21.5_ENST00000524453.1_RNA	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	919					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GCTCTAGACCGAAACCAAAGC	0.572000													29	54					0	0	1	0	0
FAM208A	23272	broad.mit.edu	37	3	56681165	56681165	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:56681165A>G	ENST00000431842.2	-	7	1336	c.412T>C	c.(412-414)Tct>Cct	p.S138P	FAM208A_ENST00000355628.5_Missense_Mutation_p.S534P|FAM208A_ENST00000493960.2_Missense_Mutation_p.S534P	NM_015224.3	NP_056039.2	Q9UK61	CC063_HUMAN	family with sequence similarity 208, member A	534										NS(1)|breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(11)|prostate(3)|skin(1)	32						TGAATCAAAGAAAATTGTAAA	0.338000													25	88					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51265502	51265502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51265502G>A	ENST00000266037.9	+	17	1653	c.1630G>A	c.(1630-1632)Gag>Aag	p.E544K		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	544	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGATATTCACGAGCTTTATGT	0.478000													18	31					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5947473	5947473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:5947473G>A	ENST00000378156.4	-	18	2623	c.2358C>T	c.(2356-2358)gtC>gtT	p.V786V	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	786					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTTGCCACGACCTCAAGCT	0.642000													16	47					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76491047	76491047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76491047C>T	ENST00000389840.5	-	39	6118	c.5994G>A	c.(5992-5994)tcG>tcA	p.S1998S	RP11-559N14.5_ENST00000591373.1_RNA|DNAH17_ENST00000585328.1_Silent_p.S2007S					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACACCTGCTTCGAGAGCAGCT	0.597000													6	19					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33289581	33289581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33289581G>A	ENST00000374542.5	-	2	326	c.122C>T	c.(121-123)tCc>tTc	p.S41F	DAXX_ENST00000477162.1_5'UTR|DAXX_ENST00000266000.6_Missense_Mutation_p.S41F|DAXX_ENST00000414083.2_Intron	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	41	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						AGGCTCAGAGGAGCTAGGGGC	0.587000			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								116	224					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64055334	64055334	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64055334C>T	ENST00000539851.1	+	4	1016	c.549C>T	c.(547-549)ttC>ttT	p.F183F	GPR137_ENST00000411458.1_Silent_p.F241F|GPR137_ENST00000438980.2_Silent_p.F183F|GPR137_ENST00000377702.4_Silent_p.F183F|GPR137_ENST00000313074.3_Silent_p.F183F	NM_001177358.1	NP_001170829.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	183						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						ACTCCCTGTTCGTCATCTGCG	0.662000													21	49					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018929	62018929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62018929G>A	ENST00000578147.1	-	24	4789	c.4713C>T	c.(4711-4713)ccC>ccT	p.P1571P	SCN4A_ENST00000435607.1_Silent_p.P1571P			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1571					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TGCCGATGGAGGGGTTGCCGC	0.577000													5	51					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15600127	15600127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15600127C>T	ENST00000378076.3	-	26	3065	c.2712G>A	c.(2710-2712)agG>agA	p.R904R		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	904					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CATCCCTCTTCCTGACAAGAT	0.498000													30	88					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39454590	39454590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39454590C>T	ENST00000280481.7	+	24	9392	c.9176C>T	c.(9175-9177)cCc>cTc	p.P3059L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	3059					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AGGAGCACACCCTCACTGGCA	0.537000													15	92					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53668167	53668167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53668167G>A	ENST00000600412.1	-	2	1496	c.1381C>T	c.(1381-1383)Cat>Tat	p.H461Y	ZNF665_ENST00000396424.3_Missense_Mutation_p.H526Y			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		AGGCTTGAATGAACACTAAAG	0.388000													44	127					0	0	1	0	0
JKAMP	51528	broad.mit.edu	37	14	59954436	59954436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:59954436G>A	ENST00000554271.1	+	3	709	c.183G>A	c.(181-183)caG>caA	p.Q61Q	JKAMP_ENST00000356057.5_Silent_p.Q55Q|JKAMP_ENST00000261247.9_Silent_p.Q47Q|RP11-701B16.2_ENST00000554253.1_RNA|JKAMP_ENST00000557560.1_3'UTR|JKAMP_ENST00000556985.1_Silent_p.Q47Q|JKAMP_ENST00000425728.2_Silent_p.Q41Q			Q9P055	JKAMP_HUMAN	JNK1/MAPK8-associated membrane protein	62					ER-associated protein catabolic process|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ubiquitin protein ligase binding			breast(1)|endometrium(1)|kidney(1)|lung(3)	6						AATATTGTCAGCCTTGCACAG	0.358000													88	193					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887508	9887508	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:9887508C>T	ENST00000306084.6	+	2	1231	c.1032C>T	c.(1030-1032)atC>atT	p.I344I	TXNDC2_ENST00000357775.4_Silent_p.I277I|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	344	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AGGGTGACATCCCCAAGTCCC	0.577000													68	133					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27949645	27949645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27949645C>T	ENST00000374005.3	-	4	525	c.237G>A	c.(235-237)gtG>gtA	p.V79V	FGR_ENST00000399173.1_Silent_p.V79V|FGR_ENST00000374004.1_Silent_p.V79V|FGR_ENST00000545953.1_Silent_p.V79V	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	79	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TGAACAGGGTCACCCCAATCC	0.562000													10	24					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25264840	25264840	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25264840T>A	ENST00000218548.6	+	7	1113	c.780T>A	c.(778-780)taT>taA	p.Y260*	ATP12A_ENST00000381946.3_Nonsense_Mutation_p.Y260*	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	260					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TCTGCTTCTATTCCACAACGT	0.547000													101	248					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72340461	72340461	+	Missense_Mutation	SNP	G	G	A	rs141653211		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72340461G>A	ENST00000389916.4	+	6	694	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	186	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CGGCATCACCGAAGTCTCCAC	0.632000													10	25					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519925	69519925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69519925G>A	ENST00000338206.5	-	5	1152	c.1143C>T	c.(1141-1143)atC>atT	p.I381I		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	381					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										TCGCCTCATAGATGCCATTGG	0.413000													62	224					0	0	1	0	0
TMEM150B	284417	broad.mit.edu	37	19	55824350	55824350	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55824350G>A	ENST00000326652.4	-	8	761	c.579C>T	c.(577-579)ttC>ttT	p.F193F	TMEM150B_ENST00000438693.1_Silent_p.F193F			A6NC51	T150B_HUMAN	transmembrane protein 150B	193						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						CGAAGAGCGCGAACAGCAGCA	0.682000													11	34					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41583305	41583305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41583305C>T	ENST00000396942.1	-	6	669	c.586G>A	c.(586-588)Gac>Aac	p.D196N	ANK1_ENST00000289734.7_Missense_Mutation_p.D196N|ANK1_ENST00000347528.4_Missense_Mutation_p.D196N|ANK1_ENST00000379758.2_Missense_Mutation_p.D196N|ANK1_ENST00000352337.4_Missense_Mutation_p.D196N|ANK1_ENST00000265709.8_Missense_Mutation_p.D229N|ANK1_ENST00000396945.1_Missense_Mutation_p.D196N			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	196	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGGTTGGGGTCGTTCTGCAGC	0.716000													7	13					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25042867	25042867	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:25042867C>T	ENST00000216336.2	-	5	780	c.744G>A	c.(742-744)ctG>ctA	p.L248L		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	248					immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		CCATCTGATCCAGCAGTTTGA	0.507000													67	289					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927205	130927205	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130927205C>T	ENST00000261655.4	-	8	804	c.640_splice	c.e8-1	p.G214_splice	RIMBP2_ENST00000536002.1_Splice_Site_p.G122_splice|RIMBP2_ENST00000535703.1_Splice_Site_p.G122_splice	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	214	SH3 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GAGGAGCTCTCCTGTTGGGTA	0.617000													5	35					0	0	1	0	0
SNRPN	6638	broad.mit.edu	37	15	25220525	25220525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25220525G>A	ENST00000444203.2	+	3	1075	c.36G>A	c.(34-36)aaG>aaA	p.K12K	SNRPN_ENST00000554227.2_Silent_p.K12K|SNRPN_ENST00000400100.1_Silent_p.K8K|SNRPN_ENST00000400098.1_Silent_p.K8K|SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000400097.1_Silent_p.K8K|SNRPN_ENST00000346403.6_Silent_p.K8K|SNRPN_ENST00000390687.4_Silent_p.K8K|SNRPN_ENST00000577565.1_Silent_p.K8K			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	8					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		AGAGTAGCAAGATGCTGCAGC	0.433000									Prader-Willi syndrome				29	96					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38538831	38538831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38538831G>A	ENST00000399017.2	+	33	7062	c.4315G>A	c.(4315-4317)Gga>Aga	p.G1439R	TTC3_ENST00000354749.2_Missense_Mutation_p.G1439R|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000355666.1_Missense_Mutation_p.G1439R	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1439					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TGAGCACTGTGGAAATTCTAA	0.423000													22	68					0	0	1	0	0
CAMK2A	815	broad.mit.edu	37	5	149627351	149627351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149627351G>A	ENST00000348628.6	-	12	1592	c.927C>T	c.(925-927)gcC>gcT	p.A309A	CAMK2A_ENST00000398376.3_Silent_p.A309A	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	309					interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTTCCTGGTGGCCAGCATCG	0.617000													4	12					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140627270	140627270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140627270C>T	ENST00000231173.3	+	1	2124	c.2124C>T	c.(2122-2124)ttC>ttT	p.F708F		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		708					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTCCTGTTCGTGGCAGTGC	0.677000													54	265					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56277733	56277733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56277733G>A	ENST00000225371.5	+	10	1795	c.1685G>A	c.(1684-1686)cGa>cAa	p.R562Q		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	562					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						AACATGCAACGAAGCCGGGAC	0.617000											OREG0024608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	70					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16992006	16992006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:16992006G>A	ENST00000377833.4	-	34	5139	c.5074C>T	c.(5074-5076)Ctc>Ttc	p.L1692F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1692	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTACCTCGGAGGGGCGCGTCT	0.463000													4	18					0	0	1	0	0
TMEM8B	51754	broad.mit.edu	37	9	35846306	35846306	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35846306G>A	ENST00000377988.2	+	8	1713	c.425G>A	c.(424-426)aGg>aAg	p.R142K	TMEM8B_ENST00000473947.1_3'UTR|TMEM8B_ENST00000439587.2_Missense_Mutation_p.R142K|TMEM8B_ENST00000377996.1_Missense_Mutation_p.R142K|TMEM8B_ENST00000377991.4_Missense_Mutation_p.R142K	NM_001042590.2	NP_001036055.1	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B	142					cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	7						AGGGTTGCCAGGCTGCGAATC	0.687000													10	69					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219875364	219875364	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219875364G>A	ENST00000341552.5	-	26	4295	c.4212C>T	c.(4210-4212)ggC>ggT	p.G1404G	CCDC108_ENST00000453220.1_Silent_p.G1404G|AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000441968.1_Silent_p.G1404G	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1404						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGGTTGTAGCCCACTCCCT	0.592000													7	14					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120876350	120876350	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120876350G>A	ENST00000273666.6	+	9	1024		c.e9-1		STXBP5L_ENST00000471454.1_Splice_Site|STXBP5L_ENST00000492541.1_Splice_Site|STXBP5L_ENST00000497029.1_Splice_Site|STXBP5L_ENST00000472879.1_Splice_Site	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like						exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		TATTTTATTAGGCTATTCATT	0.328000													15	49					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14492705	14492705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14492705C>T	ENST00000344204.4	+	49	7686	c.7662C>T	c.(7660-7662)tcC>tcT	p.S2554S	TRIO_ENST00000537187.1_Silent_p.S2378S|TRIO_ENST00000344135.5_Silent_p.S53S	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2554	SH3 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GCAACATCTCCACCATGTTGG	0.502000													17	39					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2824232	2824232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2824232C>T	ENST00000520002.1	-	59	9518	c.8963G>A	c.(8962-8964)gGa>gAa	p.G2988E	CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000400186.3_Intron|CSMD1_ENST00000602557.1_Missense_Mutation_p.G2988E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G2987E|CSMD1_ENST00000602723.1_Intron			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2988	Sushi 23.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACAATCATTCCGTTGGTGGG	0.527000													4	17					0	0	1	0	0
NSDHL	50814	broad.mit.edu	37	X	152034497	152034497	+	Silent	SNP	C	C	T	rs147293409	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:152034497C>T	ENST00000370274.3	+	6	872	c.678C>T	c.(676-678)ttC>ttT	p.F226F	NSDHL_ENST00000440023.1_Silent_p.F226F	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	226					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity	p.F226F(1)		NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	AGATGAAGTTCGTGATTGGGT	0.572000													47	38					0	0	1	0	0
CEACAM21	90273	broad.mit.edu	37	19	42082636	42082636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42082636C>T	ENST00000187608.9	+	1	50	c.10C>T	c.(10-12)Ccc>Tcc	p.P4S	CEACAM21_ENST00000407170.2_Intron|CEACAM21_ENST00000401445.2_Missense_Mutation_p.P4S|CEACAM21_ENST00000482870.2_Intron	NM_001098506.1|NM_033543.3	NP_001091976.1|NP_291021.2	Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	4						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						CATGGGGCCCCCCTCAGCTTG	0.622000													10	43					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82456472	82456472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:82456472G>A	ENST00000370728.1	+	25	4668	c.4023G>A	c.(4021-4023)aaG>aaA	p.K1341K	LPHN2_ENST00000370723.1_Silent_p.K1343K|LPHN2_ENST00000335786.5_Silent_p.K1298K|LPHN2_ENST00000370715.1_3'UTR|LPHN2_ENST00000370725.1_Silent_p.K1356K|LPHN2_ENST00000359929.3_Silent_p.K1285K|LPHN2_ENST00000394879.1_Silent_p.K1343K|LPHN2_ENST00000370727.1_Silent_p.K1313K|LPHN2_ENST00000370730.1_Silent_p.K1298K|LPHN2_ENST00000370717.2_Silent_p.K1356K|LPHN2_ENST00000319517.6_Silent_p.K1285K|LPHN2_ENST00000370713.1_3'UTR|LPHN2_ENST00000370721.1_Silent_p.K1266K|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000271029.4_Silent_p.K1313K			O95490	LPHN2_HUMAN	latrophilin 2	1341					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AACCCCAGAAGAAAGTGAAGT	0.517000													46	98					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150440092	150440092	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150440092C>T	ENST00000358647.3	+	3	1232	c.865C>T	c.(865-867)Cta>Tta	p.L289L	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTTTGTTTTTCTATTGTTGTG	0.398000													18	59					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933292	44933292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44933292C>T	ENST00000291187.4	-	6	1968	c.1646G>A	c.(1645-1647)cGg>cAg	p.R549Q	ZNF229_ENST00000588931.1_Missense_Mutation_p.R555Q|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	555					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GTCGGAGCTCCGGCCAAAGCT	0.532000													14	105					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46287520	46287520	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46287520G>A	ENST00000378966.3	+	2	668	c.252G>A	c.(250-252)cgG>cgA	p.R84R	SPERT_ENST00000310521.1_Silent_p.R120R			Q8NA61	SPERT_HUMAN	spermatid associated	120						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		ACCCGCCGCGGGTGCAGCTCA	0.627000													33	82					0	0	1	0	0
PRIMA1	145270	broad.mit.edu	37	14	94203587	94203587	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94203587C>T	ENST00000393140.1	-	4	461	c.359_splice	c.e4+1	p.R120_splice	PRIMA1_ENST00000316227.3_Splice_Site_p.R120_splice|PRIMA1_ENST00000393143.1_Splice_Site_p.R120_splice	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	120					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		GAGCACTCACCTTTTTATGGC	0.493000													16	42					0	0	1	0	0
XKR5	389610	broad.mit.edu	37	8	6679508	6679508	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:6679508G>A	ENST00000518724.1	-	0	840							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		TGCTGTCGATGATGTCACTCT	0.587000													8	7					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63676695	63676695	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63676695G>A	ENST00000402010.2	+	19	2932	c.2353G>A	c.(2353-2355)Gag>Aag	p.E785K	MARK2_ENST00000315032.8_Missense_Mutation_p.E776K|MARK2_ENST00000408948.3_Missense_Mutation_p.E688K|MARK2_ENST00000508192.1_Missense_Mutation_p.E721K|MARK2_ENST00000377809.4_Missense_Mutation_p.E770K|MARK2_ENST00000377810.3_Missense_Mutation_p.E688K|MARK2_ENST00000350490.7_Missense_Mutation_p.E706K|MARK2_ENST00000425897.2_Missense_Mutation_p.E696K|MARK2_ENST00000413835.2_Missense_Mutation_p.E731K|MARK2_ENST00000509502.2_Missense_Mutation_p.E742K|MARK2_ENST00000361128.5_Missense_Mutation_p.E716K|MARK2_ENST00000502399.3_Missense_Mutation_p.E775K|MARK2_ENST00000513765.2_Missense_Mutation_p.E752K	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	785	KA1.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						AATAGCCAACGAGCTGAAGCT	0.647000													21	56					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577226	14577226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14577226C>T	ENST00000544627.1	+	2	721	c.401C>T	c.(400-402)cCt>cTt	p.P134L	ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000536444.1_Missense_Mutation_p.P126L|ATF7IP_ENST00000543189.1_Missense_Mutation_p.P126L|ATF7IP_ENST00000540793.1_Missense_Mutation_p.P126L|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P126L			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	126					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TCTAAACTGCCTGCTGAACCA	0.473000													12	65					0	0	1	0	0
PAK4	10298	broad.mit.edu	37	19	39669068	39669068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39669068C>T	ENST00000599386.1	+	9	1347	c.1166C>T	c.(1165-1167)tCg>tTg	p.S389L	PAK4_ENST00000599470.1_Missense_Mutation_p.S389L|PAK4_ENST00000321944.4_Missense_Mutation_p.S452L|PAK4_ENST00000358301.3_Missense_Mutation_p.S542L|PAK4_ENST00000593690.1_Missense_Mutation_p.S542L|PAK4_ENST00000435673.2_Missense_Mutation_p.S542L|PAK4_ENST00000360442.3_Missense_Mutation_p.S542L	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	542	Protein kinase.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			CGACAGGTGTCGCCATCCCTG	0.672000													4	2					0	0	1	0	0
BBS7	55212	broad.mit.edu	37	4	122776679	122776679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122776679G>A	ENST00000264499.4	-	6	749	c.566C>T	c.(565-567)cCc>cTc	p.P189L	BBS7_ENST00000506636.1_Missense_Mutation_p.P189L	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	189					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						GACAGTAGGGGGTCCAGGAAC	0.348000									Bardet-Biedl syndrome				58	116					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504556	70504556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70504556G>A	ENST00000310961.5	+	22	3368	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K	LRRC7_ENST00000035383.5_Missense_Mutation_p.E979K|LRRC7_ENST00000415775.2_Missense_Mutation_p.E263K			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	979						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGGAAGCCACGAACGACCGGA	0.453000													21	70					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130341178	130341178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130341178G>A	ENST00000299164.2	+	7	1978	c.1978G>A	c.(1978-1980)Gat>Aat	p.D660N		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	660	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GGCTGGCTGTGATGGGAACCT	0.567000													9	54					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78347272	78347272	+	Missense_Mutation	SNP	G	G	A	rs35879437		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78347272G>A	ENST00000255189.3	-	5	611	c.583C>T	c.(583-585)Cct>Tct	p.P195S	DMGDH_ENST00000380311.4_Intron|DMGDH_ENST00000540686.1_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	195					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		AGAGAATAAGGATCAATGTGA	0.388000													41	98					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2910072	2910072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2910072G>A	ENST00000520002.1	-	51	8130	c.7575C>T	c.(7573-7575)ggC>ggT	p.G2525G	CSMD1_ENST00000542608.1_Silent_p.G2524G|CSMD1_ENST00000400186.3_Silent_p.G2525G|CSMD1_ENST00000602557.1_Silent_p.G2525G|CSMD1_ENST00000537824.1_Silent_p.G2524G|CSMD1_ENST00000602723.1_Silent_p.G2525G			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2525	Sushi 15.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAAGCTTGAAGCCCTCATGAC	0.507000													3	14					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2592604	2592604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2592604G>A	ENST00000155840.5	+	4	762	c.654G>A	c.(652-654)aaG>aaA	p.K218K	KCNQ1_ENST00000335475.5_Silent_p.K91K	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	218					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	TGGGCTCCAAGGGGCAGGTGT	0.682000													24	60					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954940	30954940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30954940G>A	ENST00000376296.3	+	2	1229	c.988G>A	c.(988-990)Gcc>Acc	p.A330T	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	330	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						GGCCAGCACAGCCACCAACTC	0.622000													26	335					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861734	52861734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52861734G>A	ENST00000343457.3	-	4	1460	c.1454C>T	c.(1453-1455)tCg>tTg	p.S485L		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	485						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						TGGGCTCTGCGAACTGCCAGG	0.557000													33	82					0	0	1	0	0
PPP3R2	5535	broad.mit.edu	37	9	104356906	104356906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104356906C>T	ENST00000374806.1	-	1	377	c.307G>A	c.(307-309)Gac>Aac	p.D103N	GRIN3A_ENST00000361820.3_Intron	NM_147180.2	NP_671709.1	Q96LZ3	CANB2_HUMAN	protein phosphatase 3, regulatory subunit B, beta	100	EF-hand 3.						calcium ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	TTATCCATGTCGTAAATGCTG	0.532000													29	114					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30938508	30938508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30938508C>T	ENST00000597505.1	-	24	3360	c.3361G>A	c.(3361-3363)Gaa>Aaa	p.E1121K	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Missense_Mutation_p.E200K			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TGTGAAGTTTCCTGCCAGGCA	0.418000													21	52					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935259	151935259	+	Missense_Mutation	SNP	G	G	A	rs35981027		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151935259G>A	ENST00000393902.3	-	3	1475	c.908C>T	c.(907-909)cCc>cTc	p.P303L	MAGEA3_ENST00000370278.3_Missense_Mutation_p.P303L			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	303	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CTCATGCAGGGGTGGGTAGGA	0.577000													21	128					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49219119	49219119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49219119G>A	ENST00000327979.2	-	13	1548	c.1137C>T	c.(1135-1137)atC>atT	p.I379I	FAM65C_ENST00000045083.2_Silent_p.I379I|FAM65C_ENST00000535356.1_Silent_p.I383I			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	379										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GGTAGCTGAGGATGGAGGTGG	0.647000													6	78					0	0	1	0	0
AHSP	51327	broad.mit.edu	37	16	31539877	31539877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31539877G>A	ENST00000302312.4	+	3	277	c.174G>A	c.(172-174)ggG>ggA	p.G58G	AHSP_ENST00000569954.1_3'UTR	NM_016633.2	NP_057717.1	Q9NZD4	AHSP_HUMAN	alpha hemoglobin stabilizing protein	58					hemoglobin metabolic process|hemopoiesis|protein folding|protein stabilization	hemoglobin complex	hemoglobin binding|unfolded protein binding			lung(2)	2						AGGTGACAGGGGAGCCCCAAG	0.532000													12	54					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20149272	20149272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:20149272C>T	ENST00000395530.2	+	6	2350	c.2142C>T	c.(2140-2142)gtC>gtT	p.V714V	SPECC1_ENST00000536879.1_Silent_p.V135V|AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000261503.5_Silent_p.V795V|SPECC1_ENST00000395527.4_Silent_p.V795V	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	795						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		CCTCTGAGGTCGATGCTGCTG	0.502000													22	38					0	0	1	0	0
LMOD1	25802	broad.mit.edu	37	1	201868737	201868737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201868737G>A	ENST00000367288.4	-	2	1650	c.1404C>T	c.(1402-1404)agC>agT	p.S468S	RP11-307B6.3_ENST00000458139.1_RNA|RP11-307B6.3_ENST00000414927.1_RNA	NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	468					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CCATGTTGCGGCTGAGCAGAT	0.572000													6	16					0	0	1	0	0
MTHFD2L	441024	broad.mit.edu	37	4	75167517	75167517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:75167517C>T	ENST00000395759.2	+	8	1062	c.1035C>T	c.(1033-1035)atC>atT	p.I345I	MTHFD2L_ENST00000325278.6_Silent_p.I287I	NM_001144978.1	NP_001138450.1	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	287					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			central_nervous_system(1)|endometrium(1)|lung(4)|ovary(2)	8			all cancers(17;0.0101)|Lung(101;0.196)			CTAAAAAAATCATTTACTAGA	0.363000													11	41					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148112693	148112693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148112693G>A	ENST00000361727.3	+	24	4497	c.3981G>A	c.(3979-3981)aaG>aaA	p.K1327K	CNTNAP2_ENST00000538075.1_Silent_p.K386K|CNTNAP2_ENST00000463592.2_3'UTR	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1327					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAGCAAAAAGGAATGGCTCA	0.522000										HNSCC(39;0.1)			31	48					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198948911	198948911	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:198948911C>T	ENST00000428675.1	+	2	1068	c.670C>T	c.(670-672)Cga>Tga	p.R224*	PLCL1_ENST00000437704.2_Nonsense_Mutation_p.R126*	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	224					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CCTGGTTTCTCGAAGTAAGCA	0.478000													33	85					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128492726	128492726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128492726G>A	ENST00000325888.8	+	36	6185	c.5924G>A	c.(5923-5925)aGc>aAc	p.S1975N	FLNC_ENST00000346177.6_Missense_Mutation_p.S1942N|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1975					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						AGTGATCTGAGCCAGCTGACC	0.647000													37	60					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599939	29599939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29599939C>T	ENST00000431530.3	+	1	1192	c.1134C>T	c.(1132-1134)ctC>ctT	p.L378L		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	368						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						ACAGTGACCTCCACCACCTTG	0.572000													9	31					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75500155	75500155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75500155G>A	ENST00000355774.2	-	7	3897	c.3682C>T	c.(3682-3684)Cat>Tat	p.H1228Y	MLH3_ENST00000556740.1_Missense_Mutation_p.H1228Y|MLH3_ENST00000544985.1_3'UTR|MLH3_ENST00000238662.7_Intron|MLH3_ENST00000556257.1_Intron|MLH3_ENST00000380968.2_Missense_Mutation_p.H174Y	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	1228					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding	p.H1228N(1)		breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		ATACGCTCATGGGCAGCGTGC	0.478000								Mismatch excision repair (MMR)					15	42					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14752260	14752260	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14752260G>A	ENST00000253673.5	-	10	1319	c.1219C>T	c.(1219-1221)Ctc>Ttc	p.L407F	EMR3_ENST00000599900.1_Missense_Mutation_p.L192F|EMR3_ENST00000344373.4_Missense_Mutation_p.L355F|EMR3_ENST00000443157.2_Missense_Mutation_p.L281F	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	407					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						ATCCCCACGAGGAAGAGGAGG	0.567000													20	74					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23915544	23915544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:23915544G>A	ENST00000382298.3	-	10	3059	c.2471C>T	c.(2470-2472)tCg>tTg	p.S824L	SACS_ENST00000402364.1_Missense_Mutation_p.S74L|SACS_ENST00000382292.3_Missense_Mutation_p.S824L	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	824				QTCVELIRLRIPSLVILDDES -> FLFDEDSNGKLKMVAV LITSC (in Ref. 3; CAE45964).	cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATGACTAACGATGGAATCCT	0.383000													36	82					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76900393	76900393	+	Missense_Mutation	SNP	G	G	A	rs111033214		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76900393G>A	ENST00000409709.3	+	28	3780	c.3508G>A	c.(3508-3510)Gag>Aag	p.E1170K	MYO7A_ENST00000409619.2_Missense_Mutation_p.E1159K|MYO7A_ENST00000458637.2_Missense_Mutation_p.E1170K	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1170	MyTH4 1.		E -> K (in USH1B).		actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCCCAGGGACGAGATCTACTG	0.642000													7	49					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759299	6759299	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6759299C>T	ENST00000378827.4	+	3	1973	c.754C>T	c.(754-756)Caa>Taa	p.Q252*		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	252					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GTCTTTGCACCAAGATGAACA	0.483000													10	31					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156834179	156834179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156834179G>A	ENST00000368196.3	+	2	366	c.246G>A	c.(244-246)ctG>ctA	p.L82L	NTRK1_ENST00000524377.1_Silent_p.L82L|NTRK1_ENST00000358660.3_Silent_p.L82L|NTRK1_ENST00000392302.2_Silent_p.L52L	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	82					activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGCAGCATCTGGAGCTCCGTG	0.617000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			14	36					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96916161	96916161	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96916161C>T	ENST00000267584.4	+	9	937	c.893C>T	c.(892-894)cCt>cTt	p.P298L		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	298					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		AATACTGGCCCTGGGAAAATC	0.353000													17	36					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13700828	13700828	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13700828C>T	ENST00000265104.4	-	78	13748	c.13644G>A	c.(13642-13644)agG>agA	p.R4548R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4548					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTTTCATGTTCCTCTTGTCCC	0.423000									Kartagener syndrome				84	186					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94731275	94731275	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94731275G>A	ENST00000304338.3	+	20	2342	c.2188G>A	c.(2188-2190)Gaa>Aaa	p.E730K		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	730						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TAAAATGTTTGAAAAGAAACG	0.313000													40	127					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83411176	83411176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:83411176G>A	ENST00000262752.2	-	3	172	c.165C>T	c.(163-165)atC>atT	p.I55I	RPS6KA6_ENST00000543399.1_Silent_p.I55I	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	55					axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						GAGTAATAGGGATTTCTTTAA	0.363000													8	11					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331568	70331568	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70331568C>T	ENST00000338508.4	-	32	4832	c.4833G>A	c.(4831-4833)gaG>gaA	p.E1611E	SHANK2_ENST00000423696.2_Silent_p.E1231E|SHANK2_ENST00000409161.1_Silent_p.E1014E|SHANK2_ENST00000449833.2_Silent_p.E1015E			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1231					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGCTTTTGATCTCTGTGACGT	0.592000													22	121					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55336670	55336670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:55336670C>T	ENST00000536015.1	-	18	2096	c.1977G>A	c.(1975-1977)aaG>aaA	p.K659K	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Silent_p.K659K|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	659			Missing (in PFIC1).		ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				CTTCAATTTCCTTGTAGCAAA	0.343000													12	49					0	0	1	0	0
PPP6C	5537	broad.mit.edu	37	9	127915924	127915924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127915924G>A	ENST00000451402.1	-	7	888	c.668C>T	c.(667-669)cCt>cTt	p.P223L	PPP6C_ENST00000373546.3_Missense_Mutation_p.P39L|PPP6C_ENST00000373547.4_Missense_Mutation_p.P186L|PPP6C_ENST00000415905.1_Missense_Mutation_p.P164L	NM_001123355.1	NP_001116827.1	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit	186					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						TCCTTTATGAGGAATTTCCTG	0.433000													5	58					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419274	130419274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130419274G>A	ENST00000370904.1	-	11	1429	c.519C>T	c.(517-519)gcC>gcT	p.A173A	IGSF1_ENST00000370910.1_Silent_p.A173A|IGSF1_ENST00000370903.3_Silent_p.A182A|IGSF1_ENST00000361420.3_Silent_p.A182A|IGSF1_ENST00000370900.1_Silent_p.A182A|IGSF1_ENST00000370901.4_Silent_p.A182A			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	182	Ig-like C2-type 2.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TGGAGAATATGGCCATTGTCC	0.517000													50	52					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150714977	150714977	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150714977C>T	ENST00000335244.4	-	6	786	c.657G>A	c.(655-657)cgG>cgA	p.R219R	SLC36A2_ENST00000521967.1_Silent_p.R219R	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	219					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCTGAGGTTCCGGATGAGGA	0.537000													14	80					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590255	140590255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140590255G>A	ENST00000239450.2	+	1	1965	c.1776G>A	c.(1774-1776)gtG>gtA	p.V592V	PCDHB12_ENST00000541609.1_Silent_p.V255V	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		592	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGGCGGTGGACGGTGACT	0.701000													15	301					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13397666	13397666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13397666C>T	ENST00000360228.5	-	20	3203	c.3204G>A	c.(3202-3204)atG>atA	p.M1068I	CACNA1A_ENST00000573710.2_Missense_Mutation_p.M1069I	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1069					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGTTGTTCTTCATGTTGTCAA	0.672000													11	27					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140277662	140277662	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140277662C>T	ENST00000458420.3	+	12	2194	c.2004C>T	c.(2002-2004)ttC>ttT	p.F668F		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	668					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						TGAGCACCTTCGCCAAAACCG	0.532000										HNSCC(16;0.037)			20	56					0	0	1	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206977	142206977	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142206977G>A	ENST00000426318.2	-	0	34																											TCCAGGGCAGGATCTTGTGTC	0.552000													15	25					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6093215	6093215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6093215C>T	ENST00000217289.4	-	4	1229	c.441G>A	c.(439-441)aaG>aaA	p.K147K	FERMT1_ENST00000536936.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	147	FERM.|Poly-Lys.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TCTTCTTCTTCTTAAAATAGT	0.299000													28	102					0	0	1	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140866223	140866223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140866223C>T	ENST00000306593.1	+	1	1483	c.1483C>T	c.(1483-1485)Ctg>Ttg	p.L495L	PCDHGA11_ENST00000518882.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACTCACTCCTGGAGCCCAG	0.522000													15	176					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6941024	6941024	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6941024G>A	ENST00000251761.8	+	0	1191				LEPREL2_ENST00000396725.2_RNA|LEPREL2_ENST00000538102.1_RNA|LEPREL2_ENST00000606935.1_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						CCCTGGGGGAGAAGAGGCAGC	0.612000													7	10					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12660110	12660110	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12660110G>A	ENST00000251849.4	-	2	550	c.111C>T	c.(109-111)ggC>ggT	p.G37G	RAF1_ENST00000542177.1_5'UTR|RAF1_ENST00000442415.2_Silent_p.G37G	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	37					activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	GGCGCTGATAGCCAAACTGCT	0.468000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				34	78					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20054963	20054963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20054963C>T	ENST00000245957.5	+	4	388	c.312C>T	c.(310-312)ttC>ttT	p.F104F	C20orf26_ENST00000377306.1_Silent_p.F104F|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000451767.2_Silent_p.F104F|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	104										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ATACGTTGTTCATGCACCTCT	0.507000													40	109					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59282476	59282476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59282476C>T	ENST00000329328.3	+	1	91	c.91C>T	c.(91-93)Ctg>Ttg	p.L31L		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						ATTTACCTTCCTGTTTTTGGT	0.433000													11	204					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683361	100683361	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100683361C>T	ENST00000306151.4	+	3	8728	c.8664C>T	c.(8662-8664)acC>acT	p.T2888T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2888	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.T2888T(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGGCTAGCACCCTTTCAACAA	0.483000													171	478					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139889761	139889761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139889761C>T	ENST00000297183.6	+	22	4223	c.4099C>T	c.(4099-4101)Cgc>Tgc	p.R1367C	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.R1367C|ANKHD1_ENST00000360839.2_Missense_Mutation_p.R1367C	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCAGCATTTCGCAAGGTAAT	0.388000													28	55					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55059688	55059688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55059688C>T	ENST00000371316.3	+	5	529	c.447C>T	c.(445-447)ttC>ttT	p.F149F	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000343744.2_Silent_p.F149F	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	149	Acyl coenzyme A hydrolase 1.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						TGGCCACCTTCGTGGCCCGCC	0.632000													6	57					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35183432	35183432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:35183432C>T	ENST00000381318.3	+	21	2761	c.2473C>T	c.(2473-2475)Ccc>Tcc	p.P825S	ITSN1_ENST00000399338.4_Missense_Mutation_p.P820S|ITSN1_ENST00000399355.2_Missense_Mutation_p.P825S|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000437442.2_Missense_Mutation_p.P820S|ITSN1_ENST00000399367.3_Missense_Mutation_p.P820S|ITSN1_ENST00000399352.1_Missense_Mutation_p.P820S|ITSN1_ENST00000399326.3_Missense_Mutation_p.P820S|ITSN1_ENST00000399349.1_Missense_Mutation_p.P820S|ITSN1_ENST00000399353.1_Missense_Mutation_p.P783S|ITSN1_ENST00000381291.4_Missense_Mutation_p.P825S|ITSN1_ENST00000379960.5_Missense_Mutation_p.P820S|ITSN1_ENST00000381285.4_Missense_Mutation_p.P825S	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	825					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						TGCCCCTGCCCCCAAACTGGC	0.552000													23	105					0	0	1	0	0
DNHD1	144132	broad.mit.edu	37	11	6532654	6532654	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6532654C>T	ENST00000254579.6	+	7	1951	c.1387C>T	c.(1387-1389)Cga>Tga	p.R463*	DNHD1_ENST00000527990.2_Nonsense_Mutation_p.R463*|DNHD1_ENST00000354685.3_Nonsense_Mutation_p.R463*	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	463					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ATCCATTCTTCGACTGGTAAG	0.517000													46	94					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141721479	141721479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141721479G>A	ENST00000475668.2	+	6	706	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K	MGAM_ENST00000549489.2_Missense_Mutation_p.E218K			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	218	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTACCAAGTTGAAATCTCCAG	0.438000													33	97					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24654769	24654769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24654769G>A	ENST00000354464.6	-	13	1350	c.1174C>T	c.(1174-1176)Ctg>Ttg	p.L392L	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	392					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		AGTGGGGGCAGCAGTCTGGAT	0.552000													25	57					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55444962	55444962	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55444962G>A	ENST00000588756.1	-	10	3103	c.2617C>T	c.(2617-2619)Cct>Tct	p.P873S	NLRP7_ENST00000328092.5_Missense_Mutation_p.P845S|NLRP7_ENST00000340844.2_Missense_Mutation_p.P873S|NLRP7_ENST00000448121.2_Missense_Mutation_p.P845S|NLRP7_ENST00000590030.1_Missense_Mutation_p.P873S|NLRP7_ENST00000592784.1_Missense_Mutation_p.P873S|NLRP7_ENST00000446217.1_Missense_Mutation_p.P901S			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	873							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TTACAATCAGGGTAACTCAAG	0.483000													15	53					0	0	1	0	0
TRAF2	7186	broad.mit.edu	37	9	139815663	139815663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139815663C>T	ENST00000359662.3	+	9	1335	c.1290C>T	c.(1288-1290)tcC>tcT	p.S430S	TRAF2_ENST00000536468.1_Silent_p.S378S|TRAF2_ENST00000247668.2_Silent_p.S378S			Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	378	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		CCATCTTCTCCCCAGGTGTGG	0.602000													16	41					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180335746	180335746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180335746G>A	ENST00000231229.4	+	2	444	c.210G>A	c.(208-210)ggG>ggA	p.G70G	BTNL8_ENST00000508408.1_Silent_p.G70G|BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000340184.4_Silent_p.G70G	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	70	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGGGACGGGAAGGACCAGC	0.532000													65	116					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165491	172165491	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172165491T>C	ENST00000241256.2	-	1	755	c.713A>G	c.(712-714)aAg>aGg	p.K238R	GHSR_ENST00000427970.1_Missense_Mutation_p.K238R	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	238					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CCGCCACAGCTTCCTGCCGAT	0.607000													17	42					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20801637	20801637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20801637G>A	ENST00000359062.3	+	13	2621	c.2581G>A	c.(2581-2583)Gat>Aat	p.D861N	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	861	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GCTATATAACGATCGTTCAGT	0.368000													39	107					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94650952	94650952	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94650952C>T	ENST00000260526.6	-	17	2048	c.1866G>A	c.(1864-1866)acG>acA	p.T622T	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	622					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity	p.T622T(1)		NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CCCTACATTTCGTGGGGGATC	0.398000													29	95					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53639522	53639522	+	Missense_Mutation	SNP	G	G	A	rs151332923	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:53639522G>A	ENST00000262135.4	-	24	3559	c.3466C>T	c.(3466-3468)Cgc>Tgc	p.R1156C	RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.R1202C|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.R1190C|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.R1236C	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	1236					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				ACGGTGAAGCGAAGGCTGGTA	0.517000													5	65					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539929	94539929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94539929G>A	ENST00000289495.5	+	1	720	c.504G>A	c.(502-504)ggG>ggA	p.G168G	PPP1R9A_ENST00000424654.1_Silent_p.G168G|PPP1R9A_ENST00000433360.1_Silent_p.G168G|PPP1R9A_ENST00000340694.4_Silent_p.G168G|PPP1R9A_ENST00000456331.2_Silent_p.G168G|PPP1R9A_ENST00000433881.1_Silent_p.G168G	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	168						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAGCTGGAGGGAGTGAACCTC	0.493000										HNSCC(28;0.073)			35	55					0	0	1	0	0
CYB561D1	284613	broad.mit.edu	37	1	110038505	110038505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110038505C>T	ENST00000420578.2	+	3	354	c.314C>T	c.(313-315)gCt>gTt	p.A105V	CYB561D1_ENST00000527072.1_3'UTR|CYB561D1_ENST00000369868.3_Missense_Mutation_p.A127V|CYB561D1_ENST00000310611.4_3'UTR|CYB561D1_ENST00000430195.2_3'UTR|CYB561D1_ENST00000393709.3_Missense_Mutation_p.A48V|CYB561D1_ENST00000528785.1_Missense_Mutation_p.A105V|CYB561D1_ENST00000496961.1_3'UTR|CYB561D1_ENST00000533024.1_3'UTR			Q8N8Q1	C56D1_HUMAN	cytochrome b561 family, member D1	105	Cytochrome b561.				electron transport chain|transport	integral to membrane	metal ion binding			breast(1)|large_intestine(3)|prostate(1)	5		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0422)|Epithelial(280;0.0655)|all cancers(265;0.0685)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		CTCTGTGCAGCTCTGGGCCTG	0.612000													57	131					0	0	1	0	0
MFNG	4242	broad.mit.edu	37	22	37882141	37882141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37882141C>T	ENST00000356998.3	-	1	298	c.75G>A	c.(73-75)cgG>cgA	p.R25R	MFNG_ENST00000416983.3_Silent_p.R25R	NM_002405.3	NP_002396.2	O00587	MFNG_HUMAN	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	25					pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			large_intestine(2)|lung(2)|skin(1)	5	Melanoma(58;0.0574)					TCAAGTGGTACCGCAGACACA	0.667000													18	44					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108339003	108339003	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:108339003G>A	ENST00000344440.6	-	26	3377	c.3378C>T	c.(3376-3378)atC>atT	p.I1126I	SORCS1_ENST00000263054.6_Intron|SORCS1_ENST00000369698.1_Silent_p.I661I	NM_001013031.2|NM_001206569.1|NM_001206571.1|NM_001206572.1	NP_001013049.1|NP_001193498.1|NP_001193500.1|NP_001193501.1	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	1126						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TAATCCCCGGGATCTTCCTAA	0.468000													41	168					0	0	1	0	0
FAM193B	54540	broad.mit.edu	37	5	176951947	176951947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176951947G>A	ENST00000329540.5	-	9	3242	c.413C>T	c.(412-414)cCt>cTt	p.P138L	FAM193B_ENST00000443375.2_Missense_Mutation_p.P479L|FAM193B_ENST00000514747.1_Missense_Mutation_p.P512L			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	188										kidney(1)|large_intestine(3)	4						TAGACTCTGAGGCTCAGGCTC	0.557000													20	18					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201521630	201521630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:201521630G>A	ENST00000374700.2	+	27	3382	c.3141G>A	c.(3139-3141)atG>atA	p.M1047I	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	1047					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GAATTGAAATGGGGCAGGGGG	0.433000													10	84					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669549	234669549	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234669549T>A	ENST00000360418.3	+	1	616	c.616T>A	c.(616-618)Ttc>Atc	p.F206I	UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A1_ENST00000305208.5_Missense_Mutation_p.F206I|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A10_ENST00000373445.1_Intron			P22309	UD11_HUMAN		206					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	TCACATGACCTTCCTGCAGCG	0.527000													54	192					0	0	1	0	0
SNRPA1	6627	broad.mit.edu	37	15	101833366	101833366	+	Missense_Mutation	SNP	G	G	A	rs138801817	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101833366G>A	ENST00000254193.6	-	2	166	c.94C>T	c.(94-96)Ccc>Tcc	p.P32S	SNRPA1_ENST00000560856.1_5'UTR	NM_003090.2	NP_003081.2	P09661	RU2A_HUMAN	small nuclear ribonucleoprotein polypeptide A'	32						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCAATGACGGGAATTTTATAC	0.348000													7	39					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57865728	57865728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57865728G>A	ENST00000228682.2	+	12	3296	c.3205G>A	c.(3205-3207)Ggc>Agc	p.G1069S	GLI1_ENST00000546141.1_Missense_Mutation_p.G1028S|GLI1_ENST00000543426.1_Missense_Mutation_p.G941S	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	1069					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			TGATCAGCGGGGCAGCTCTGG	0.572000													16	198					0	0	1	0	0
SERINC2	347735	broad.mit.edu	37	1	31896549	31896549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:31896549C>T	ENST00000373710.1	+	3	349	c.76C>T	c.(76-78)Ctc>Ttc	p.L26F	SERINC2_ENST00000373709.3_Missense_Mutation_p.L17F|SERINC2_ENST00000536859.1_Missense_Mutation_p.L21F|SERINC2_ENST00000536384.1_Missense_Mutation_p.L21F|SERINC2_ENST00000491976.1_3'UTR	NM_001199038.1	NP_001185967.1	Q96SA4	SERC2_HUMAN	serine incorporator 2	17						integral to membrane				cervix(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	12		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		GGCGTCCTGCCTCTGCGGCTC	0.672000													5	44					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216420478	216420478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216420478C>T	ENST00000366943.2	-	13	2644	c.2258G>A	c.(2257-2259)gGc>gAc	p.G753D	USH2A_ENST00000366942.3_Missense_Mutation_p.G753D|USH2A_ENST00000307340.3_Missense_Mutation_p.G753D			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	753	Laminin EGF-like 5.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTCACTGAGCCATGGAGGTT	0.428000										HNSCC(13;0.011)			13	145					0	0	1	0	0
PLCD1	5333	broad.mit.edu	37	3	38065836	38065836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38065836C>T	ENST00000463876.1	-	1	442	c.89G>A	c.(88-90)cGg>cAg	p.R30Q	PLCD1_ENST00000334661.4_Intron	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	0	PH.|Substrate binding (By similarity).				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		ACCCAGCCTCCGTCCATTGAG	0.667000													15	34					0	0	1	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24523833	24523833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:24523833G>A	ENST00000376862.3	+	2	733	c.100G>A	c.(100-102)Gag>Aag	p.E34K		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	34					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						CTTGATGGCCGAGAGCAGAGA	0.552000													28	88					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25235776	25235776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:25235776G>A	ENST00000219660.5	+	4	606	c.481G>A	c.(481-483)Gag>Aag	p.E161K	AQP8_ENST00000566125.1_Missense_Mutation_p.E155K	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	161					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		GTTGGTGGCAGAGATCATCCT	0.617000													14	50					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189065209	189065209	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189065209C>T	ENST00000332517.3	+	5	918	c.778C>T	c.(778-780)Cag>Tag	p.Q260*	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	260					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		ACTCTTGCTTCAGTGTCCAGA	0.552000													8	29					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152583269	152583269	+	Silent	SNP	G	G	A	rs138173087		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152583269G>A	ENST00000367255.5	-	101	19471	c.18870C>T	c.(18868-18870)tcC>tcT	p.S6290S	SYNE1_ENST00000448038.1_Silent_p.S6219S|SYNE1_ENST00000423061.1_Silent_p.S6219S|SYNE1_ENST00000265368.4_Silent_p.S6290S|SYNE1_ENST00000341594.5_Silent_p.S5902S|SYNE1_ENST00000356820.4_Silent_p.S814S	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6290					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGTCTTCAGCGGATGATTTCT	0.393000										HNSCC(10;0.0054)			23	41					0	0	1	0	0
CLEC5A	23601	broad.mit.edu	37	7	141645147	141645147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141645147C>T	ENST00000546910.1	-	3	329	c.133G>A	c.(133-135)Gga>Aga	p.G45R	CLEC5A_ENST00000439991.1_Missense_Mutation_p.M9I|CLEC5A_ENST00000551012.2_Missense_Mutation_p.G45R|CLEC5A_ENST00000470595.1_Intron|CLEC5A_ENST00000438351.1_Missense_Mutation_p.G45R	NM_013252.2	NP_037384.1	Q9NY25	CLC5A_HUMAN	C-type lectin domain family 5, member A	45					anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	10	Melanoma(164;0.0171)					TTACCTGTTCCATAGCTCCTG	0.458000													39	59					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961675	34961675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34961675C>T	ENST00000329357.5	+	1	763	c.727C>T	c.(727-729)Cgc>Tgc	p.R243C		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	243	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCCAGAGACTCGCGCATCTCA	0.647000													7	58					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23729755	23729755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23729755C>T	ENST00000304749.2	-	2	310	c.240G>A	c.(238-240)ggG>ggA	p.G80G	CST1_ENST00000398402.1_Silent_p.G80G	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	80						extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					AGTAATTCACCCCCCCAACGG	0.557000													34	185					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119727715	119727715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:119727715G>A	ENST00000327097.4	+	3	360	c.225G>A	c.(223-225)cgG>cgA	p.R75R	MARCO_ENST00000541757.1_5'UTR	NM_006770.3	NP_006761.1	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	75					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						CGCGGCTCCGGGTCCTGGAGA	0.562000													19	75					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101818647	101818647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101818647C>T	ENST00000375001.3	+	35	3721	c.3298C>T	c.(3298-3300)Ccc>Tcc	p.P1100S		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1100	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GCCACCGGGGCCCCCGGGGCC	0.622000													13	64					0	0	1	0	0
HRASLS5	117245	broad.mit.edu	37	11	63235883	63235883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63235883C>T	ENST00000540857.1	-	4	532	c.400G>A	c.(400-402)Gag>Aag	p.E134K	HRASLS5_ENST00000539221.1_Missense_Mutation_p.E144K|HRASLS5_ENST00000301790.4_Missense_Mutation_p.E144K	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201.1|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	144										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						GCCCAGTGCTCATAGCCAATT	0.408000													44	111					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117120290	117120290	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117120290G>A	ENST00000307564.4	-	12	2811	c.2650C>T	c.(2650-2652)Caa>Taa	p.Q884*	AKNA_ENST00000223791.3_Nonsense_Mutation_p.Q344*|AKNA_ENST00000374075.5_Nonsense_Mutation_p.Q803*|AKNA_ENST00000374088.3_Nonsense_Mutation_p.Q884*	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	884					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						ATACTACTTTGGTGGGATGCT	0.647000													19	57					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095234	69095234	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69095234C>T	ENST00000332644.5	-	8	848	c.686_splice	c.e8-1	p.K229_splice		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	229	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						AATTATTTTTCCTAGAGGACA	0.323000													16	56					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55012616	55012616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:55012616G>A	ENST00000371336.3	+	2	634	c.433G>A	c.(433-435)Gaa>Aaa	p.E145K	CASS4_ENST00000360314.3_Missense_Mutation_p.E145K|CASS4_ENST00000434344.1_Missense_Mutation_p.E145K	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	145					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						AATCATCTGTGAAAAGACTCT	0.537000													59	85					0	0	1	0	0
GJB6	10804	broad.mit.edu	37	13	20797319	20797319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:20797319C>T	ENST00000356192.6	-	5	921	c.301G>A	c.(301-303)Gaa>Aaa	p.E101K	GJB6_ENST00000400065.3_Missense_Mutation_p.E101K|GJB6_ENST00000241124.6_Missense_Mutation_p.E101K|GJB6_ENST00000400066.3_Missense_Mutation_p.E101K	NM_001110219.2	NP_001103689.1	O95452	CXB6_HUMAN	gap junction protein, beta 6, 30kDa	101					cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	9		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		CGAGTGGTTTCGTGCCTGTAG	0.552000													12	41					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171520495	171520495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:171520495G>A	ENST00000176763.5	-	9	1818	c.1475C>T	c.(1474-1476)aCc>aTc	p.T492I	STK10_ENST00000517775.1_5'UTR	NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	492							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCTCTCAGAGGTGCAGAGGCT	0.597000													51	147					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358346	10358346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10358346C>T	ENST00000255381.2	-	21	2457	c.2347G>A	c.(2347-2349)Gaa>Aaa	p.E783K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	783	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GCTAGCTTTTCATCTCGCATT	0.443000													28	44					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186015882	186015882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186015882C>T	ENST00000265022.3	-	4	820	c.281G>A	c.(280-282)gGa>gAa	p.G94E	DGKG_ENST00000344484.4_Missense_Mutation_p.G94E|DGKG_ENST00000544847.1_Missense_Mutation_p.G94E|DGKG_ENST00000382164.4_Missense_Mutation_p.G94E	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	94					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	GTTGCTGGCTCCCTCCGTCGG	0.617000													22	97					0	0	1	0	0
GK5	256356	broad.mit.edu	37	3	141944199	141944199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141944199G>A	ENST00000392993.2	-	1	250	c.99C>T	c.(97-99)tgC>tgT	p.C33C	GK5_ENST00000544571.1_Silent_p.C33C|GK5_ENST00000466685.3_5'UTR	NM_001039547.2	NP_001034636.1	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	33					glycerol metabolic process		ATP binding|glycerol kinase activity			kidney(1)|large_intestine(1)|lung(7)|urinary_tract(1)	10						CATAGACGTGGCAGCGGATCA	0.701000													5	6					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69727233	69727233	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:69727233C>T	ENST00000349945.1	+	14	4775	c.3223C>T	c.(3223-3225)Cag>Tag	p.Q1075*	NFAT5_ENST00000432919.1_Nonsense_Mutation_p.Q1169*|NFAT5_ENST00000567239.1_Nonsense_Mutation_p.Q1168*|NFAT5_ENST00000566899.1_Nonsense_Mutation_p.Q1075*|NFAT5_ENST00000354436.2_Nonsense_Mutation_p.Q1151*|NFAT5_ENST00000393742.2_Nonsense_Mutation_p.Q1075*	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1151					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GAATAATCTTCAGACTAACAC	0.428000													68	152					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76417042	76417042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76417042C>T	ENST00000357063.3	+	26	5503	c.4243C>T	c.(4243-4245)Cct>Tct	p.P1415S	LMO7_ENST00000377534.3_Missense_Mutation_p.P1415S|LMO7_ENST00000321797.8_Missense_Mutation_p.P1130S|LMO7_ENST00000526202.1_Missense_Mutation_p.P1007S|LMO7_ENST00000341547.4_Missense_Mutation_p.P1081S|LMO7_ENST00000465261.2_Missense_Mutation_p.P1130S			Q8WWI1	LMO7_HUMAN	LIM domain 7	1415						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AGGTTTTCTTCCTGGTGACAG	0.328000													35	85					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103310945	103310945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103310945G>A	ENST00000233969.2	+	6	1640	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K	SLC9A2_ENST00000469286.1_3'UTR	NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	500						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						AGCTGTCAGTGAAGAAATCTA	0.363000													15	67					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26689562	26689562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26689562C>T	ENST00000436292.1	-	5	1218	c.1098G>A	c.(1096-1098)caG>caA	p.Q366Q	ZNF683_ENST00000374204.1_Silent_p.Q366Q|ZNF683_ENST00000403843.1_Silent_p.Q366Q|ZNF683_ENST00000349618.3_Silent_p.Q366Q			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGTGGTGCTTCTGCAGGTGGG	0.577000													5	15					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15967683	15967683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:15967683C>T	ENST00000350896.3	-	9	1275	c.1078G>A	c.(1078-1080)Gaa>Aaa	p.E360K	MSR1_ENST00000262101.5_Missense_Mutation_p.E423K|MSR1_ENST00000445506.2_Missense_Mutation_p.E441K|MSR1_ENST00000355282.2_Missense_Mutation_p.E360K	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	423	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATAGATGATTCTCTCCCAAAA	0.373000													49	85					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51920657	51920657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51920657C>T	ENST00000353836.5	-	2	321	c.100G>A	c.(100-102)Ggc>Agc	p.G34S	SIGLEC10_ENST00000339313.5_Missense_Mutation_p.G34S|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.G34S|CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.G34S|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.G34S|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.G34S|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.G34S|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.G34S|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.G34S	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	34	Ig-like V-type.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		ATGCACAGGCCCTCCGGCACC	0.592000													22	69					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8000065	8000065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8000065G>A	ENST00000380149.1	-	15	2514	c.2484C>T	c.(2482-2484)atC>atT	p.I828I	ALOXE3_ENST00000448843.2_Silent_p.I672I|ALOXE3_ENST00000318227.3_Silent_p.I804I			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	672					leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						GGAAGGCGGCGATGCTCCGCC	0.622000													31	45					0	0	1	0	0
TMEM67	91147	broad.mit.edu	37	8	94822081	94822081	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:94822081C>T	ENST00000453321.3	+	26	2788	c.2730C>T	c.(2728-2730)ttC>ttT	p.F910F	TMEM67_ENST00000409623.3_Silent_p.F829F	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	910					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			GAATGGAATTCATGGAACCAA	0.299000													18	54					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531463	50531463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50531463G>A	ENST00000374144.3	+	3	1161	c.873G>A	c.(871-873)aaG>aaA	p.K291K	C10orf71_ENST00000323868.4_Silent_p.K291K			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	291										endometrium(1)	1						TGGAGAGAAAGGACACAGCTG	0.537000													12	23					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166152463	166152463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166152463G>A	ENST00000357398.3	+	2	420	c.130G>A	c.(130-132)Gag>Aag	p.E44K	SCN2A_ENST00000375437.2_Missense_Mutation_p.E44K|SCN2A_ENST00000375427.2_Missense_Mutation_p.E44K|SCN2A_ENST00000283256.6_Missense_Mutation_p.E44K			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	44					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	ACGCAAGGATGAGGATGATGA	0.463000													7	47					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204002981	204002981	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:204002981C>T	ENST00000449802.1	+	29	4908	c.4575C>T	c.(4573-4575)atC>atT	p.I1525I		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1525							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TAGTGCTGATCATACAGGACT	0.373000													27	74					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067218	190067218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190067218G>A	ENST00000367462.3	-	8	2462	c.2231C>T	c.(2230-2232)tCt>tTt	p.S744F	FAM5C_ENST00000534846.1_Missense_Mutation_p.S642F|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		744						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CTGCAGAGCAGATTGGATCCT	0.428000													47	109					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964202	70964202	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70964202C>T	ENST00000357250.6	-	25	1854	c.1696G>A	c.(1696-1698)Gat>Aat	p.D566N	COL9A1_ENST00000370499.4_Missense_Mutation_p.D323N|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000320755.7_Missense_Mutation_p.D323N	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	566	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AATCCTGCATCACCAGGAGGC	0.383000													8	69					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471630	61471630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61471630G>A	ENST00000398019.2	+	8	1229	c.904G>A	c.(904-906)Gaa>Aaa	p.E302K	SERPINB7_ENST00000336429.2_Missense_Mutation_p.E302K|SERPINB7_ENST00000546027.1_Missense_Mutation_p.E302K|SERPINB7_ENST00000540675.1_Missense_Mutation_p.E285K	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	302					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				TATCTTTGATGAATCCAAAGC	0.408000													26	55					0	0	1	0	0
TBC1D20	128637	broad.mit.edu	37	20	428611	428611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:428611G>A	ENST00000354200.4	-	2	325	c.178C>T	c.(178-180)Ctc>Ttc	p.L60F		NM_144628.2	NP_653229.1	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	60	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(17;0.228)|Breast(17;0.231)				TCAGTCAGGAGCCCTCCTTCA	0.527000													18	55					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45861601	45861601	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45861601C>T	ENST00000397928.1	+	32	4858	c.4413C>T	c.(4411-4413)gcC>gcT	p.A1471A	TRPM2_ENST00000300481.9_Silent_p.A1417A|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Silent_p.A1471A|TRPM2_ENST00000397932.2_Silent_p.A1521A	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1471	Nudix hydrolase.					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ACTCGGGGGCCTCCATCCGAT	0.652000													7	36					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107703405	107703405	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107703405C>T	ENST00000388781.3	-	23	3179	c.3096G>A	c.(3094-3096)atG>atA	p.M1032I	LAMB4_ENST00000205386.4_Missense_Mutation_p.M1032I|LAMB4_ENST00000388780.3_Missense_Mutation_p.M1032I	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1032	Laminin EGF-like 11.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GGGGACACTCCATGGGACTCA	0.532000													18	39					0	0	1	0	0
QRFPR	84109	broad.mit.edu	37	4	122250756	122250756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122250756C>T	ENST00000394427.2	-	6	1420	c.1009G>A	c.(1009-1011)Gaa>Aaa	p.E337K	QRFPR_ENST00000334383.5_3'UTR	NM_198179.2	NP_937822.2	Q96P65	QRFPR_HUMAN	pyroglutamylated RFamide peptide receptor	337						plasma membrane	neuropeptide Y receptor activity			endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(2)|skin(3)|stomach(1)	28						TTGAAGTTTTCATTCATAAAT	0.323000													13	46					0	0	1	0	0
RGL4	266747	broad.mit.edu	37	22	24036125	24036125	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24036125G>A	ENST00000290691.5	+	4	2046	c.876G>A	c.(874-876)agG>agA	p.R292R	RGL4_ENST00000401461.1_Silent_p.R156R	NM_153615.1	NP_705843.1	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation stimulator-like 4	292	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(3)	15						CCCGGGACAGGGCCAGGGTGG	0.592000													27	61					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003966	57003966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57003966C>T	ENST00000606794.1	-	1	709	c.513G>A	c.(511-513)ggG>ggA	p.G171G		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	171						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TCTCCAAGTCCCCGGTGGTGC	0.647000													18	45					0	0	1	0	0
FIZ1	84922	broad.mit.edu	37	19	56109072	56109072	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56109072G>A	ENST00000221665.3	-	2	249	c.160C>T	c.(160-162)Ccg>Tcg	p.P54S	FIZ1_ENST00000592585.1_Intron	NM_032836.2	NP_116225.2	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)	11			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CCGCAGCGCGGACATGCGTGG	0.657000													12	99					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74640034	74640034	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74640034T>A	ENST00000253159.8	+	25	4758	c.4560T>A	c.(4558-4560)tcT>tcA	p.S1520S	ZNF236_ENST00000320610.9_Silent_p.S1522S	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1520					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCTCGGGGTCTCCACAGGAAA	0.498000													6	48					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209782374	209782374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209782374G>A	ENST00000009105.1	+	8	930	c.685G>A	c.(685-687)Gag>Aag	p.E229K	CAMK1G_ENST00000494990.1_3'UTR|CAMK1G_ENST00000361322.2_Missense_Mutation_p.E229K			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	229	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		TAAGCTTTTCGAGAAGATCAA	0.493000													55	120					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79429952	79429952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79429952C>T	ENST00000264895.6	+	63	10012	c.9572C>T	c.(9571-9573)tCc>tTc	p.S3191F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3186					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						AAATCCCCCTCCCCAGGCTAC	0.542000													4	27					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119934770	119934770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119934770G>A	ENST00000361035.4	+	7	1131	c.848G>A	c.(847-849)gGg>gAg	p.G283E	HAO2_ENST00000325945.3_Missense_Mutation_p.G270E	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	270	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		GCTGTAAAGGGGAAAATTGAA	0.488000													15	65					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51693415	51693415	+	Silent	SNP	C	C	T	rs150740618	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51693415C>T	ENST00000267012.4	-	6	553	c.492G>A	c.(490-492)aaG>aaA	p.K164K	BIN2_ENST00000544402.1_Silent_p.K138K|BIN2_ENST00000452142.2_Silent_p.K132K|BIN2_ENST00000604560.1_Silent_p.K137K	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	164	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						CCTCATCTTTCTTCTTGGCAT	0.517000													73	142					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756558	248756558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248756558G>A	ENST00000330500.2	-	1	542	c.512C>T	c.(511-513)tCc>tTc	p.S171F		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AATCTCATGGGATCTGCAGAA	0.507000													28	117					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489273	237489273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:237489273C>T	ENST00000272928.3	+	2	475	c.165C>T	c.(163-165)ttC>ttT	p.F55F		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		TTTTCATCTTCGTCATCGGCA	0.522000													4	22					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42327846	42327846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42327846C>T	ENST00000262418.6	-	20	2871	c.2716G>A	c.(2716-2718)Gaa>Aaa	p.E906K		NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	906	Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		ATGGCCACTTCGTCGTATTCA	0.597000													17	21					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052500	15052500	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15052500C>G	ENST00000248072.3	+	1	200	c.200C>G	c.(199-201)tCc>tGc	p.S67C		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TCCAACCTGTCCTTTGCTGAC	0.483000													17	77					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275650	152275650	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152275650G>A	ENST00000368799.1	-	3	11747	c.11712C>T	c.(11710-11712)tcC>tcT	p.S3904S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3904	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGCGGTGAGAGGATCCGGGGT	0.502000									Ichthyosis				30	88					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189675740	189675740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189675740C>T	ENST00000319332.5	-	15	2285	c.2088G>A	c.(2086-2088)ggG>ggA	p.G696G	LEPREL1_ENST00000427335.2_Silent_p.G515G	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	696					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GTTCATGCTTCCCTTGCTGTT	0.313000											OREG0015985	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	92					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113163237	113163237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113163237G>A	ENST00000401783.2	-	40	10055	c.9719C>T	c.(9718-9720)tCt>tTt	p.S3240F	SVEP1_ENST00000374469.1_Missense_Mutation_p.S3217F|SVEP1_ENST00000297826.5_Missense_Mutation_p.S1166F	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3240	Sushi 31.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TTTCCCACAAGAAACTGGACT	0.388000													13	40					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13601076	13601076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13601076C>T	ENST00000606117.1	+	9	1048	c.752C>T	c.(751-753)tCc>tTc	p.S251F	SIRT5_ENST00000359782.3_Missense_Mutation_p.S233F|SIRT5_ENST00000397350.2_Missense_Mutation_p.S143F|SIRT5_ENST00000379262.4_Missense_Mutation_p.S251F	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	251	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	GTGGGCACTTCCTCTGTGGTG	0.537000													7	34					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	169780949	169780949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169780949C>T	ENST00000377360.4	+	1	459	c.69C>T	c.(67-69)atC>atT	p.I23I	KCNIP1_ENST00000518527.1_3'UTR	NM_001034838.2	NP_001030010.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	0					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTAAGCTCATCACTGGGACCC	0.557000													19	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579281	179579281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179579281C>T	ENST00000589042.1	-	91	26444	c.26220G>A	c.(26218-26220)aaG>aaA	p.K8740K	TTN_ENST00000342992.6_Silent_p.K7496K|TTN_ENST00000591111.1_Silent_p.K8423K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8423	Ig-like 70.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGAGCTTCTTCACAAATC	0.438000													11	29					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54914862	54914862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54914862C>T	ENST00000474759.1	+	21	1932	c.1884C>T	c.(1882-1884)ttC>ttT	p.F628F	CACNA2D3_ENST00000490478.1_Silent_p.F534F|CACNA2D3-AS1_ENST00000471265.1_RNA|CACNA2D3_ENST00000288197.5_Silent_p.F628F|CACNA2D3_ENST00000415676.2_Silent_p.F628F	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	628						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GGAAATATTTCTTCCGAGGGA	0.483000													94	239					0	0	1	0	0
BCL2L12	83596	broad.mit.edu	37	19	50170331	50170331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50170331C>T	ENST00000246785.3	+	3	673	c.415C>T	c.(415-417)Ccc>Tcc	p.P139S	BCL2L12_ENST00000441864.2_Missense_Mutation_p.P138S|BCL2L12_ENST00000246784.3_Intron	NM_001040668.1|NM_138639.1	NP_001035758.1|NP_619580.1	Q9HB09	B2L12_HUMAN	BCL2-like 12 (proline rich)	139					apoptosis					central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	8		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		AAGATGTCTTCCCTGCTCCCT	0.607000													28	68					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10435073	10435073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10435073C>T	ENST00000245503.5	-	22	2958	c.2574G>A	c.(2572-2574)atG>atA	p.M858I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.M858I|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	858					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ATTCTTCCTTCATGGTGGCCA	0.423000													39	51					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38921528	38921528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38921528G>A	ENST00000302328.3	-	19	3504	c.3306C>T	c.(3304-3306)atC>atT	p.I1102I	SCN11A_ENST00000456224.3_Silent_p.I1064I|SCN11A_ENST00000444237.2_Silent_p.I1102I|SCN11A_ENST00000450244.1_Silent_p.I1102I	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1102					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCATCTCCAGGATAAAAATAT	0.348000													17	34					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542092	55542092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55542092G>A	ENST00000220676.1	+	4	5798	c.5650G>A	c.(5650-5652)Gat>Aat	p.D1884N		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1884					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGTCTCTGATGATGCTATTAA	0.408000													30	80					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88423632	88423632	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88423632G>A	ENST00000394480.1	-	18	2482	c.2161C>T	c.(2161-2163)Cgc>Tgc	p.R721C	NTRK3_ENST00000355254.2_Missense_Mutation_p.R721C|NTRK3_ENST00000357724.2_Missense_Mutation_p.R727C|NTRK3_ENST00000360948.2_Missense_Mutation_p.R735C|NTRK3_ENST00000557856.1_Missense_Mutation_p.R713C	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	735	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.R721F(1)	ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGCATCCAGCGAATGGGGAGC	0.507000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			32	47					0	0	1	0	0
G3BP2	9908	broad.mit.edu	37	4	76571592	76571592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76571592C>T	ENST00000359707.4	-	11	1891	c.1106G>A	c.(1105-1107)gGa>gAa	p.G369E	G3BP2_ENST00000395719.3_Missense_Mutation_p.G369E|G3BP2_ENST00000357854.3_Missense_Mutation_p.G336E	NM_203505.2	NP_987101.1	Q9UN86	G3BP2_HUMAN	GTPase activating protein (SH3 domain) binding protein 2	369	RRM.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	27			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TGGAAGCTTTCCCCCAACACC	0.348000													68	176					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987944	50987944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50987944G>A	ENST00000395676.2	+	1	1483	c.1349G>A	c.(1348-1350)gGg>gAg	p.G450E		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	450										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCTGCCGTGGGGACATCTAC	0.672000													32	79					0	0	1	0	0
KCNE3	10008	broad.mit.edu	37	11	74168606	74168606	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74168606C>T	ENST00000310128.4	-	3	422	c.3G>A	c.(1-3)atG>atA	p.M1I	RP11-702H23.4_ENST00000533008.1_RNA|KCNE3_ENST00000525550.1_Start_Codon_SNP_p.M1I	NM_005472.4	NP_005463.1	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related family, member 3	1						integral to membrane	voltage-gated potassium channel activity			cervix(1)|large_intestine(1)|lung(1)|ovary(1)	4	Breast(11;2.86e-06)					TGGTAGTCTCCATAGCAACAG	0.542000													19	64					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674678	167674678	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167674678C>T	ENST00000519204.1	+	26	6489	c.6371C>T	c.(6370-6372)cCc>cTc	p.P2124L	TENM2_ENST00000545108.1_Missense_Mutation_p.P2244L|TENM2_ENST00000518659.1_Missense_Mutation_p.P2245L|TENM2_ENST00000520394.1_Missense_Mutation_p.P2006L|TENM2_ENST00000403607.2_Missense_Mutation_p.P2069L					teneurin transmembrane protein 2																		CGCCTCATGCCCTTGCGCTAT	0.557000													12	35					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	39966963	39966963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39966963G>A	ENST00000336649.4	+	1	206	c.206G>A	c.(205-207)cGg>cAg	p.R69Q	CACNA1I_ENST00000407673.1_Missense_Mutation_p.R69Q|CACNA1I_ENST00000404898.1_Missense_Mutation_p.R69Q|CACNA1I_ENST00000402142.3_Missense_Mutation_p.R69Q|CACNA1I_ENST00000401624.1_Missense_Mutation_p.R69Q|CACNA1I_ENST00000400164.3_Missense_Mutation_p.R69Q			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	69					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ACCAGCCCCCGGAACTGGTGC	0.637000													8	127					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74401595	74401595	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74401595G>A	ENST00000319380.7	-	2	541	c.477_splice	c.e2+1	p.T159_splice		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	159							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						CAGGACTCACGGTGGATCGCA	0.602000													4	10					0	0	1	0	0
MYCL	4610	broad.mit.edu	37	1	40363568	40363568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40363568C>T	ENST00000397332.2	-	3	785	c.661G>A	c.(661-663)Gtg>Atg	p.V221M	MYCL_ENST00000372816.2_Missense_Mutation_p.V191M|RP1-118J21.5_ENST00000418255.1_RNA	NM_001033081.2|NM_001033082.2	NP_001028253.1|NP_001028254.2			v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog																		TCTGCTCGCACCGTGATGGTG	0.502000													22	91					0	0	1	0	0
TNP2	7142	broad.mit.edu	37	16	11361859	11361859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11361859G>A	ENST00000312693.3	-	2	480	c.411C>T	c.(409-411)tcC>tcT	p.S137S	RMI2_ENST00000572173.1_Intron	NM_005425.4	NP_005416.1	Q05952	STP2_HUMAN	transition protein 2 (during histone to protamine replacement)	137					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding	p.0?(1)		large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6						CTCATTAGTTGGATTTCCATC	0.443000													8	12					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287790	16287790	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:16287790G>A	ENST00000343518.6	-	1	147	c.96C>T	c.(94-96)ttC>ttT	p.F32F		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	32										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TGCACCAGGCGAAGCAGTGGC	0.582000													93	264					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186006591	186006591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186006591G>A	ENST00000265022.3	-	6	991	c.452C>T	c.(451-453)tCt>tTt	p.S151F	DGKG_ENST00000344484.4_Missense_Mutation_p.S151F|DGKG_ENST00000544847.1_Missense_Mutation_p.S151F|DGKG_ENST00000382164.4_Missense_Mutation_p.S151F	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	151	Poly-Ser.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CGAGCTTGAAGACCGAGGGAC	0.552000													110	264					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75408420	75408420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75408420C>T	ENST00000394810.2	-	4	1139	c.990G>A	c.(988-990)acG>acA	p.T330T	SYNPO2L_ENST00000372873.4_Silent_p.T106T|SYNPO2L_ENST00000372872.4_Silent_p.T330T	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	330						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					CGGACTCACTCGTGGGGGGAA	0.607000													25	62					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36051420	36051420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36051420G>A	ENST00000262623.3	-	6	660	c.632C>T	c.(631-633)cCc>cTc	p.P211L		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	211					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GATGTCGGCGGGCACTCTGTC	0.627000													9	61					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119926576	119926576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119926576C>T	ENST00000327554.2	+	5	927	c.462C>T	c.(460-462)ttC>ttT	p.F154F	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	154										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		AGCCCCTCTTCCGCCAGCTCT	0.517000													23	55					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58207538	58207538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58207538G>A	ENST00000302572.2	-	1	108	c.87C>T	c.(85-87)ttC>ttT	p.F29F		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGATGAAAAGGAAGACTATGA	0.458000													25	89					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19206957	19206957	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19206957C>T	ENST00000318596.7	+	2	175	c.24C>T	c.(22-24)ggC>ggT	p.G8G		NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	8					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			TGAAGGAAGGCCCGGTGCGAT	0.612000													10	27					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139277969	139277969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139277969G>A	ENST00000395297.1	-	4	444	c.274C>T	c.(274-276)Cat>Tat	p.H92Y		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	92										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AAGAGTAAATGAACTCGGAAG	0.473000										HNSCC(54;0.14)			28	70					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935937	30935937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30935937G>A	ENST00000355537.3	+	2	1615	c.1468G>A	c.(1468-1470)Gga>Aga	p.G490R		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTCCCTCCTGGGATGCCTCAA	0.657000													26	54					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7169850	7169850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7169850C>T	ENST00000406697.1	+	6	705	c.77C>T	c.(76-78)cCt>cTt	p.P26L	C1S_ENST00000328916.3_Missense_Mutation_p.P26L|C1S_ENST00000402681.3_Intron|C1S_ENST00000360817.5_Missense_Mutation_p.P26L			P09871	C1S_HUMAN	complement component 1, s subcomponent	26	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	ATCCTGTCCCCTAACTATCCT	0.473000													17	83					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167039	140167039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140167039C>T	ENST00000504120.2	+	1	1164	c.1164C>T	c.(1162-1164)tcC>tcT	p.S388S	PCDHA1_ENST00000378133.3_Silent_p.S388S|PCDHA1_ENST00000394633.3_Silent_p.S388S	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACTTGCTCCTTAATGCCCC	0.567000													61	116					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55331371	55331371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55331371C>T	ENST00000391728.4	+	4	592	c.559C>T	c.(559-561)Ctt>Ttt	p.L187F	KIR3DL1_ENST00000541392.1_Missense_Mutation_p.L187F|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.L187F|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.L187F|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.L92F|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.L187F	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		TCCCATGATGCTTGCCCTTGC	0.547000													38	140					0	0	1	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240738	26240738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26240738G>A	ENST00000377745.2	+	1	178	c.85G>A	c.(85-87)Ggc>Agc	p.G29S		NM_003540.3	NP_003531.1	P62805	H4_HUMAN	histone cluster 1, H4f	29					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CAACATACAGGGCATCACGAA	0.557000													9	34					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56737280	56737280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56737280G>A	ENST00000314128.4	-	24	2472	c.2449C>T	c.(2449-2451)Ccg>Tcg	p.P817S	STAT2_ENST00000557235.1_Missense_Mutation_p.P813S|STAT2_ENST00000556539.1_5'UTR			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	817					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						TCACCATTCGGCATGATTTCT	0.507000													26	42					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37272064	37272064	+	Missense_Mutation	SNP	C	C	T	rs146292447		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37272064C>T	ENST00000397147.4	+	8	1181	c.997C>T	c.(997-999)Ccc>Tcc	p.P333S	NCF4_ENST00000248899.6_Intron	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	0					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						GCCTGTCACCCCCTTAGGGAC	0.617000													12	34					0	0	1	0	0
GABBR1	2550	broad.mit.edu	37	6	29595317	29595317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29595317G>A	ENST00000377034.4	-	6	938	c.603C>T	c.(601-603)agC>agT	p.S201S	GABBR1_ENST00000377012.4_Silent_p.S84S|GABBR1_ENST00000377016.4_Silent_p.S139S|GABBR1_ENST00000376977.3_Silent_p.S201S|GABBR1_ENST00000355973.3_Silent_p.S84S	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	201					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	TGTCCCTGCGGCTATTCACGT	0.677000													8	11					0	0	1	0	0
NAIF1	203245	broad.mit.edu	37	9	130825767	130825767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130825767G>A	ENST00000373078.4	-	2	1143	c.924C>T	c.(922-924)gcC>gcT	p.A308A	NAIF1_ENST00000488519.1_5'UTR	NM_197956.3	NP_931045.1	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	308					apoptosis|induction of apoptosis	nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CAGAGGCGGGGGCCGGGTTAG	0.627000													25	90					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634069	32634069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32634069G>A	ENST00000242310.4	-	1	1598	c.1509C>T	c.(1507-1509)atC>atT	p.I503I	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	503					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CATCCCAAATGATATTGTCCT	0.478000													36	130					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117977565	117977565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117977565G>A	ENST00000425217.1	-	10	1613	c.1559C>T	c.(1558-1560)tCc>tTc	p.S520F	KSR2_ENST00000302438.5_Missense_Mutation_p.S246F|KSR2_ENST00000339824.5_Missense_Mutation_p.S549F|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	549	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity	p.S581F(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCACTGTGGGGAAGGGTGTAG	0.642000													7	34					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133883780	133883780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133883780G>A	ENST00000220616.4	+	4	502	c.462G>A	c.(460-462)ctG>ctA	p.L154L	TG_ENST00000377869.1_Silent_p.L154L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	154	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCCGCCAGCTGGGGAGGCCAA	0.592000													13	20					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47876552	47876552	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47876552G>A	ENST00000289672.2	-	37	5960	c.5910C>T	c.(5908-5910)ctC>ctT	p.L1970L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1970					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CCAGGGCAGTGAGACACGCGT	0.602000													9	27					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788484	42788484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42788484C>T	ENST00000372980.3	-	2	1815	c.943G>A	c.(943-945)Gag>Aag	p.E315K		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	315					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CACTCGCCCTCGTAGCGGAGG	0.657000													20	33					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17230663	17230663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17230663G>A	ENST00000180173.5	-	2	145	c.111C>T	c.(109-111)ttC>ttT	p.F37F	MTMR7_ENST00000521857.1_Silent_p.F37F	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	37							protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		AATTTTCCACGAATATGACAT	0.403000													8	37					0	0	1	0	0
SCARF2	91179	broad.mit.edu	37	22	20779730	20779730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20779730G>A	ENST00000405555.3	-	11	2603	c.2533C>T	c.(2533-2535)Ccg>Tcg	p.P845S	SCARF2_ENST00000266214.5_Missense_Mutation_p.P850S	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	846	Pro-rich.				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TTGCGCGGCGGCTTCTGGATG	0.756000													5	16					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72889588	72889588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:72889588C>T	ENST00000264839.7	+	5	782	c.782C>T	c.(781-783)tCc>tTc	p.S261F	RIMS1_ENST00000348717.5_Missense_Mutation_p.S261F|RIMS1_ENST00000520567.1_Missense_Mutation_p.S261F|RIMS1_ENST00000517960.1_Missense_Mutation_p.S261F|RIMS1_ENST00000521978.1_Missense_Mutation_p.S261F|RIMS1_ENST00000522291.1_Missense_Mutation_p.S261F|RIMS1_ENST00000518273.1_Missense_Mutation_p.S261F|RIMS1_ENST00000491071.2_Missense_Mutation_p.S261F			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	261					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAGGCTTCATCCAGGTCTAGA	0.527000													6	11					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186059893	186059893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186059893C>T	ENST00000271588.4	+	64	9960	c.9731C>T	c.(9730-9732)cCt>cTt	p.P3244L	HMCN1_ENST00000367492.2_Missense_Mutation_p.P3244L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3244					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCCAAAGTTCCTCCAAGTGTT	0.358000													22	72					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208835	58208835	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58208835C>T	ENST00000377918.3	+	1	2181	c.2155C>T	c.(2155-2157)Ctc>Ttc	p.L719F		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	719					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CTCCATCATCCTCCTAGCGGC	0.607000													19	68					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5770965	5770965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5770965G>A	ENST00000381624.3	+	19	1706	c.1645G>A	c.(1645-1647)Gac>Aac	p.D549N	CATSPERD_ENST00000309164.7_3'UTR|CATSPERD_ENST00000381614.2_Missense_Mutation_p.D207N	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	549						integral to membrane											GGAATTCTACGACCCCGGCTT	0.547000													30	72					0	0	1	0	0
CKMT1A	548596	broad.mit.edu	37	15	43990917	43990917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43990917G>A	ENST00000413453.2	+	8	1614	c.1090G>A	c.(1090-1092)Ggc>Agc	p.G364S	CKMT1A_ENST00000434505.1_Missense_Mutation_p.G364S|STRC_ENST00000541030.1_Intron			P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1A	364	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity			lung(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	TGCTGCCACAGGCGGTGTCTT	0.502000													49	83					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54362336	54362336	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:54362336C>T	ENST00000306888.2	-	5	1167	c.916G>A	c.(916-918)Gat>Aat	p.D306N	LNX1_ENST00000263925.7_Missense_Mutation_p.D402N|FIP1L1_ENST00000507166.1_Intron	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	402	PDZ 1.					cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			CCAGGCTCATCCACCTTGCGC	0.522000													14	171					0	0	1	0	0
APOA5	116519	broad.mit.edu	37	11	116661629	116661629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:116661629G>A	ENST00000542499.1	-	4	388	c.316C>T	c.(316-318)Cgc>Tgc	p.R106C	APOA5_ENST00000227665.4_Missense_Mutation_p.R106C	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	106					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		GGCTGGAGGCGAGCCTTCACC	0.642000													29	79					0	0	1	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32713033	32713033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32713033G>A	ENST00000374940.3	+	2	282	c.180G>A	c.(178-180)gtG>gtA	p.V60V		NM_020056.4	NP_064440.1	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ alpha 2	60	Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			endometrium(2)|large_intestine(3)|lung(7)|skin(1)	13					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGTTCTATGTGGACCTGGAGA	0.483000													48	170					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1081113	1081113	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1081113A>G	ENST00000441003.2	+	11	1436	c.1409A>G	c.(1408-1410)gAg>gGg	p.E470G	MUC2_ENST00000359061.5_Missense_Mutation_p.E470G	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	470	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CTGCTCAACGAGCTGCAGGTG	0.667000													8	45					0	0	1	0	0
IGLV7-43	28776	broad.mit.edu	37	22	22749721	22749721	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22749721G>A	ENST00000390298.2	+	0	279																											ACCCCTGCCCGGTTCTCAGGC	0.547000													31	40					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	136969778	136969778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:136969778C>T	ENST00000508657.1	-	12	2016	c.1302G>A	c.(1300-1302)gcG>gcA	p.A434A	KLHL3_ENST00000541417.1_Intron|KLHL3_ENST00000506491.1_Silent_p.A384A|KLHL3_ENST00000506873.1_5'UTR|KLHL3_ENST00000309755.4_Silent_p.A466A	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	466						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		ATTCATTGGTCGCTGGGTTGT	0.552000													23	124					0	0	1	0	0
DOK4	55715	broad.mit.edu	37	16	57507918	57507918	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57507918G>A	ENST00000566936.1	-	6	930	c.633C>T	c.(631-633)ttC>ttT	p.F211F	DOK4_ENST00000340099.4_Silent_p.F211F|DOK4_ENST00000569548.1_Silent_p.F211F			Q8TEW6	DOK4_HUMAN	docking protein 4	211	IRS-type PTB.						insulin receptor binding			kidney(1)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	6						CTTGTGTCTGGAAGGTATAGA	0.572000													10	70					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84553916	84553916	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84553916C>T	ENST00000286744.5	+	10	1248	c.1024C>T	c.(1024-1026)Cag>Tag	p.Q342*	ADAMTSL3_ENST00000567476.1_Nonsense_Mutation_p.Q342*	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	342						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CATCAGTCATCAGTGGAGACA	0.468000													12	48					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24528491	24528491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24528491C>T	ENST00000342740.5	+	21	1793	c.1639C>T	c.(1639-1641)Ctg>Ttg	p.L547L	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	547										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		CCTGCAGTCACTGTCGGTGGC	0.647000													15	33					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1092130	1092130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1092130G>A	ENST00000441003.2	+	30	3976	c.3949G>A	c.(3949-3951)Ggc>Agc	p.G1317S	MUC2_ENST00000359061.5_Missense_Mutation_p.G1318S	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1317						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCCCAGCAGTGGCAGCGACGA	0.592000													9	21					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93499834	93499834	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93499834C>T	ENST00000394196.4	+	16	3023	c.1955C>T	c.(1954-1956)tCc>tTc	p.S652F	CHD2_ENST00000557381.1_Missense_Mutation_p.S652F	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	652	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CTTCAGAATTCCCTCAAAGAG	0.433000													47	138					0	0	1	0	0
FASTKD5	60493	broad.mit.edu	37	20	3128799	3128799	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3128799G>A	ENST00000380266.3	-	2	1239	c.918C>T	c.(916-918)atC>atT	p.I306I	UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000217173.2_Intron|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	306					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						TATATTTAAGGATCAATGATT	0.358000													34	88					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102815	22102815	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22102815G>A	ENST00000542433.1	-	1	281	c.184C>T	c.(184-186)Cgc>Tgc	p.R62C		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TACATGGGGCGAGCACAGAGC	0.512000													30	68					0	0	1	0	0
MAB21L3	126868	broad.mit.edu	37	1	116670241	116670241	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:116670241C>T	ENST00000369500.3	+	5	901	c.636C>T	c.(634-636)tcC>tcT	p.S212S	MAB21L3_ENST00000464946.1_3'UTR	NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	212										breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						GCTGGCCTTCCCAAGAGAGAG	0.587000													9	25					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25451449	25451449	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25451449G>A	ENST00000424208.1	+	0	2384				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA|SNORD115-20_ENST00000365099.1_RNA	NR_003305.1																						GAAGAGAGGTGATGACTTAAA	0.498000													96	425					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31463235	31463235	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31463235G>A	ENST00000261592.5	-	10	1993	c.1696C>T	c.(1696-1698)Cta>Tta	p.L566L	NOL4_ENST00000535475.1_Silent_p.L347L|NOL4_ENST00000269185.4_Silent_p.L350L|NOL4_ENST00000535384.1_Silent_p.L281L|NOL4_ENST00000538587.1_Silent_p.L492L|NOL4_ENST00000589544.1_Silent_p.L464L	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	566						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TTCAGATTTAGCAGACCCCCT	0.393000													80	194					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345431	33345431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33345431G>A	ENST00000374796.2	-	8	3690	c.1120C>T	c.(1120-1122)Cct>Tct	p.P374S	NCOA6_ENST00000359003.2_Missense_Mutation_p.P374S			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	374	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|Poly-Pro.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						GGATATGGAGGGGGAGGGTGG	0.562000													54	90					0	0	1	0	0
TAS2R20	259295	broad.mit.edu	37	12	11150314	11150314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11150314G>A	ENST00000538986.1	-	1	160	c.161C>T	c.(160-162)tCc>tTc	p.S54F	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176889.2	NP_795370.2	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	54					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						ACCAACTCTGGAGACTGCCAG	0.348000													34	68					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013021	73013021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73013021C>T	ENST00000308744.6	+	4	1159	c.1061C>T	c.(1060-1062)cCt>cTt	p.P354L	NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000358749.3_Missense_Mutation_p.P252L|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000395999.1_Missense_Mutation_p.P255L	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	354					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GCTGCAGTTCCTCACACAGGC	0.498000													28	64					0	0	1	0	0
TJP2	9414	broad.mit.edu	37	9	71833266	71833266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71833266C>T	ENST00000377245.4	+	4	541	c.333C>T	c.(331-333)gtC>gtT	p.V111V	TJP2_ENST00000539225.1_Silent_p.V142V|TJP2_ENST00000265384.7_Silent_p.V111V|TJP2_ENST00000453658.2_Silent_p.V88V|TJP2_ENST00000377259.1_Silent_p.V88V|TJP2_ENST00000348208.4_Silent_p.V111V|TJP2_ENST00000535702.1_Silent_p.V115V	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	111	PDZ 1.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						GTGGGAAGGTCGCTGCTATTG	0.433000													25	46					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8130997	8130997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8130997C>T	ENST00000600128.1	-	64	8650	c.8236G>A	c.(8236-8238)Gag>Aag	p.E2746K	FBN3_ENST00000601739.1_Missense_Mutation_p.E2746K|FBN3_ENST00000270509.2_Missense_Mutation_p.E2746K			Q75N90	FBN3_HUMAN	fibrillin 3	2746						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AAACCTTGCTCGTTTCCGCGG	0.687000													30	91					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2886878	2886878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2886878C>T	ENST00000520002.1	-	52	8376	c.7821G>A	c.(7819-7821)ggG>ggA	p.G2607G	CSMD1_ENST00000542608.1_Silent_p.G2606G|CSMD1_ENST00000400186.3_Silent_p.G2607G|CSMD1_ENST00000602557.1_Silent_p.G2607G|CSMD1_ENST00000537824.1_Silent_p.G2606G|CSMD1_ENST00000602723.1_Silent_p.G2607G			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2607	Sushi 16.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTTCCACGTCCCATTGGCCT	0.517000													5	24					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63174098	63174098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63174098G>A	ENST00000279178.3	+	7	1452	c.1203G>A	c.(1201-1203)ctG>ctA	p.L401L	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	401					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						CTTGGGCACTGAAATACATGA	0.483000													10	100					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062045	9062045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9062045G>A	ENST00000397910.4	-	3	25604	c.25401C>T	c.(25399-25401)ttC>ttT	p.F8467F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8469	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGATATGGTGAACTGATCAG	0.493000													48	185					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117929	20117929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20117929C>T	ENST00000397165.2	-	4	542	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	ZNF682_ENST00000593468.1_3'UTR|ZNF682_ENST00000595736.1_Missense_Mutation_p.E52K|ZNF682_ENST00000597972.1_Missense_Mutation_p.E134K|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000397162.1_Missense_Mutation_p.E96K|ZNF682_ENST00000358523.5_Missense_Mutation_p.E96K	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TTATAAATTTCTTTTTGATCC	0.328000													25	55					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6063514	6063514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6063514C>T	ENST00000379959.3	-	4	683	c.510G>A	c.(508-510)atG>atA	p.M170I	IL2RA_ENST00000379954.1_Intron|IL2RA_ENST00000256876.6_Missense_Mutation_p.M170I	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	170	Sushi 2.				cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TCCCGTGGGTCATTTTGCAGA	0.537000													54	144					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94048819	94048819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94048819G>A	ENST00000297268.6	+	34	2506	c.2035G>A	c.(2035-2037)Ggt>Agt	p.G679S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	679			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGGTGCTCCTGGTGCTGTAGG	0.453000										HNSCC(75;0.22)			23	56					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109779736	109779736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109779736C>T	ENST00000356711.2	+	31	3949	c.3823C>T	c.(3823-3825)Cct>Tct	p.P1275S	MYO16_ENST00000357550.2_Missense_Mutation_p.P1275S|MYO16_ENST00000457511.2_Missense_Mutation_p.P787S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1275					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CATCTGGTCTCCTTCGCTGCA	0.642000													9	18					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42830653	42830653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42830653G>A	ENST00000398600.2	+	19	2982	c.1957G>A	c.(1957-1959)Gct>Act	p.A653T	MX1_ENST00000455164.2_Missense_Mutation_p.A653T|MX1_ENST00000288383.6_Missense_Mutation_p.A630T|MX1_ENST00000398598.3_Missense_Mutation_p.A653T	NM_001144925.1	NP_001138397.1	P20591	MX1_HUMAN	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	653	GED.				induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GCTGACGCAGGCTCGGCGCCG	0.652000													8	54					0	0	1	0	0
C9orf173	441476	broad.mit.edu	37	9	140146307	140146307	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140146307G>A	ENST00000388931.3	+	2	254	c.228G>A	c.(226-228)caG>caA	p.Q76Q	C9orf173_ENST00000412566.1_Silent_p.Q76Q	NM_001004353.3|NM_001256699.1|NM_001256700.1|NM_001256701.1	NP_001004353.2|NP_001243628.1|NP_001243629.1|NP_001243630.1	Q8N7X2	CI173_HUMAN	chromosome 9 open reading frame 173	76										kidney(1)|large_intestine(1)|lung(5)|pancreas(1)	8						GCACCCCCCAGGAGTCCCTGC	0.647000													4	8					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76414572	76414572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76414572C>T	ENST00000357063.3	+	23	4939	c.3679C>T	c.(3679-3681)Caa>Taa	p.Q1227*	LMO7_ENST00000377534.3_Nonsense_Mutation_p.Q1227*|LMO7_ENST00000321797.8_Nonsense_Mutation_p.Q942*|LMO7_ENST00000526202.1_Nonsense_Mutation_p.Q819*|LMO7_ENST00000341547.4_Nonsense_Mutation_p.Q893*|LMO7_ENST00000465261.2_Nonsense_Mutation_p.Q942*			Q8WWI1	LMO7_HUMAN	LIM domain 7	1227						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GGTGTGGGATCAAGAGGAGGA	0.527000													14	32					0	0	1	0	0
PPP2R3B	28227	broad.mit.edu	37	X	295177	295177	+	Silent	SNP	G	G	A	rs148086983	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:295177G>A	ENST00000390665.3	-	13	1671	c.1653C>T	c.(1651-1653)ttC>ttT	p.F551F		NM_013239.4	NP_037371.2	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'', beta	551					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGGGCGCCTCGAAGAAGGGCC	0.711000													13	26					0	0	1	0	0
VGLL1	51442	broad.mit.edu	37	X	135618328	135618328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135618328G>A	ENST00000370634.3	+	2	319	c.149G>A	c.(148-150)aGc>aAc	p.S50N		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					AGAGCTCTGAGCAATATCAAG	0.527000													22	34					0	0	1	0	0
ANTXR2	118429	broad.mit.edu	37	4	80899252	80899252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:80899252G>A	ENST00000403729.2	-	15	1781	c.1256C>T	c.(1255-1257)cCt>cTt	p.P419L	ANTXR2_ENST00000307333.7_Missense_Mutation_p.P419L|ANTXR2_ENST00000404191.1_Missense_Mutation_p.P342L|ANTXR2_ENST00000346652.6_Missense_Mutation_p.P316L	NM_058172.5	NP_477520.2	P58335	ANTR2_HUMAN	anthrax toxin receptor 2	419						endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						TGTTTCTTCAGGAATCTTCAC	0.483000									Juvenile Hyaline Fibromatosis				26	60					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10080327	10080327	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10080327C>T	ENST00000264828.3	-	56	4107	c.4022G>A	c.(4021-4023)aGg>aAg	p.R1341K		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1341	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TGGACCCGTCCTCCCTGGGGG	0.682000													6	17					0	0	1	0	0
P4HA3	283208	broad.mit.edu	37	11	73980758	73980758	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73980758G>A	ENST00000331597.4	-	11	1451	c.1406C>T	c.(1405-1407)tCg>tTg	p.S469L	P4HA3_ENST00000427714.2_Missense_Mutation_p.S469L	NM_182904.3	NP_878907.1	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha polypeptide III	469	Fe2OG dioxygenase.					endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(1)	15	Breast(11;2.31e-05)					AGCTTCCACCGAGCTCAGCTA	0.547000													23	50					0	0	1	0	0
TPRG1	285386	broad.mit.edu	37	3	188956533	188956533	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:188956533G>A	ENST00000345063.3	+	4	481	c.314G>A	c.(313-315)tGg>tAg	p.W105*	TPRG1_ENST00000433971.1_Nonsense_Mutation_p.W105*|TPRG1-AS2_ENST00000425454.1_RNA	NM_198485.3	NP_940887.1	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	105										endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|skin(2)|urinary_tract(1)	16	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		ATAGACCACTGGAACAATGAG	0.413000													45	91					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38959949	38959949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38959949C>T	ENST00000355481.4	+	27	3692	c.3561C>T	c.(3559-3561)ttC>ttT	p.F1187F	RYR1_ENST00000359596.3_Silent_p.F1187F|RYR1_ENST00000360985.3_Silent_p.F1187F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1187	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	cACCAGGCTTCCTGCCCGTCT	0.647000													28	62					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903178	6903178	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:6903178C>T	ENST00000486284.1	+	1	377	c.103C>T	c.(103-105)Cag>Tag	p.Q35*	GRM7_ENST00000403881.1_Nonsense_Mutation_p.Q35*|GRM7_ENST00000389336.4_Nonsense_Mutation_p.Q35*|GRM7_ENST00000402647.2_Nonsense_Mutation_p.Q35*|GRM7_ENST00000357716.4_Nonsense_Mutation_p.Q35*	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	35					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GGCGCGCGGCCAGGAGATGTA	0.701000													3	4					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71054852	71054852	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71054852T>A	ENST00000283228.2	-	12	2086	c.1634A>T	c.(1633-1635)aAg>aTg	p.K545M	PTPRR_ENST00000537619.2_5'UTR|PTPRR_ENST00000549308.1_Missense_Mutation_p.K300M|PTPRR_ENST00000440835.2_Missense_Mutation_p.K300M|PTPRR_ENST00000342084.4_Missense_Mutation_p.K433M|PTPRR_ENST00000378778.1_Missense_Mutation_p.K339M	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	545	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CCAGTAATGCTTCACATGTTG	0.473000													10	21					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84520207	84520207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84520207G>A	ENST00000360700.4	+	6	1748	c.862G>A	c.(862-864)Gag>Aag	p.E288K	ZNF711_ENST00000373165.3_Missense_Mutation_p.E288K|ZNF711_ENST00000276123.3_Missense_Mutation_p.E288K|ZNF711_ENST00000395402.1_Missense_Mutation_p.E266K|ZNF711_ENST00000542798.1_Missense_Mutation_p.E84K			Q9Y462	ZN711_HUMAN	zinc finger protein 711	288					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						AATGCAGCGGGAGAAGATGGT	0.418000													41	29					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2908728	2908728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:2908728C>T	ENST00000254695.8	+	15	1356	c.1266C>T	c.(1264-1266)ttC>ttT	p.F422F	RAP1GAP2_ENST00000366401.4_Silent_p.F407F|RAP1GAP2_ENST00000540393.2_Silent_p.F403F|RAP1GAP2_ENST00000542807.1_Silent_p.F422F	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	422	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						CCCCCGTTTTCCAGAAGGTAG	0.572000													24	146					0	0	1	0	0
CREB3L3	84699	broad.mit.edu	37	19	4168353	4168353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4168353G>A	ENST00000078445.2	+	6	867	c.720G>A	c.(718-720)gaG>gaA	p.E240E	CREB3L3_ENST00000595923.1_Silent_p.E239E|CREB3L3_ENST00000252587.3_Silent_p.E180E|CREB3L3_ENST00000602257.1_Silent_p.E238E|CREB3L3_ENST00000602147.1_Intron	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	240					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCAGTACGAGGAGCGAGTGC	0.542000													8	48					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131466464	131466464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:131466464G>A	ENST00000261654.5	+	5	905	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	GPR133_ENST00000535015.1_Missense_Mutation_p.E148K	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	116					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GACACAAGGAGAACAGTCTAG	0.502000													14	83					0	0	1	0	0
MAP3K3	4215	broad.mit.edu	37	17	61735251	61735251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61735251C>T	ENST00000361357.3	+	6	776	c.458C>T	c.(457-459)tCc>tTc	p.S153F	MAP3K3_ENST00000579585.1_Missense_Mutation_p.S153F|MAP3K3_ENST00000577395.1_Missense_Mutation_p.S122F|MAP3K3_ENST00000361733.3_Missense_Mutation_p.S122F|MAP3K3_ENST00000584573.1_Missense_Mutation_p.S153F	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	122					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						TTGCTGTTGTCCCAGGACAGA	0.438000													20	61					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75022292	75022292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75022292G>A	ENST00000261978.4	-	4	1321	c.935C>T	c.(934-936)tCc>tTc	p.S312F	CTD-2207P18.1_ENST00000554552.1_lincRNA|LTBP2_ENST00000557425.1_Intron|LTBP2_ENST00000556690.1_Missense_Mutation_p.S312F	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	312					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CAGGGCGTTGGAAGAGAGCTG	0.657000													13	78					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155953	151155953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151155953G>A	ENST00000282466.3	-	6	6395	c.6396C>T	c.(6394-6396)gtC>gtT	p.V2132V	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2132	Ig-like C2-type 7.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGTTAAGTGGACCTTCATTT	0.443000													7	51					0	0	1	0	0
SLC23A1	9963	broad.mit.edu	37	5	138707942	138707942	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:138707942C>T	ENST00000353963.3	-	14	1600	c.1561_splice	c.e14-1	p.G521_splice	SLC23A1_ENST00000348729.3_Splice_Site_p.G517_splice	NM_152685.3	NP_689898.2	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 1	517					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(5)|ovary(1)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	CTCTGGGCTCCCTGGAAGAGG	0.537000													19	41					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89261523	89261523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89261523C>T	ENST00000289746.2	+	14	2470	c.2405C>T	c.(2404-2406)cCt>cTt	p.P802L		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	802					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGTCTTTCTCCTGGGGCACTG	0.687000													16	21					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65909276	65909276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:65909276C>T	ENST00000321892.4	+	13	5715	c.5654C>T	c.(5653-5655)cCt>cTt	p.P1885L	BPTF_ENST00000306378.6_Missense_Mutation_p.P1759L|BPTF_ENST00000424123.3_Missense_Mutation_p.P1746L|BPTF_ENST00000335221.5_Missense_Mutation_p.P1885L			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1885					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TATCCTTCTCCTAGACCGACC	0.373000													56	171					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204589039	204589039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204589039G>A	ENST00000367175.1	-	1	2294	c.82C>T	c.(82-84)Ccc>Tcc	p.P28S	LRRN2_ENST00000496057.1_5'UTR|LRRN2_ENST00000367176.3_Missense_Mutation_p.P28S|LRRN2_ENST00000367177.3_Missense_Mutation_p.P28S			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	28	LRRNT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GGGGGGCAGGGAACATGCCAG	0.647000													6	26					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224475603	224475603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:224475603G>A	ENST00000281701.6	-	14	1927	c.1668C>T	c.(1666-1668)ttC>ttT	p.F556F	NVL_ENST00000340871.4_Silent_p.F367F|NVL_ENST00000361463.3_Silent_p.F450F|NVL_ENST00000469075.1_Silent_p.F465F|NVL_ENST00000482491.1_Silent_p.F280F|NVL_ENST00000391875.2_Silent_p.F450F	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	556						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity	p.F556L(1)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		GAGCAACAATGAAATCATTCA	0.478000													25	56					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149129188	149129188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149129188G>A	ENST00000247930.4	-	6	2498	c.2175C>T	c.(2173-2175)ccC>ccT	p.P725P		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCTCGCACTCGGGGCACTTGA	0.672000													25	109					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52540748	52540748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52540748G>A	ENST00000321725.6	+	18	1947	c.1871G>A	c.(1870-1872)aGg>aAg	p.R624K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	624	FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCGCTGCAGAGGGTAGACGTG	0.692000													5	22					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111667826	111667826	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111667826G>A	ENST00000431670.2	+	10	2946	c.2535G>A	c.(2533-2535)acG>acA	p.T845T	PHLDB2_ENST00000412622.1_Silent_p.T802T|PHLDB2_ENST00000495180.1_Intron|PHLDB2_ENST00000481953.1_Silent_p.T802T|PHLDB2_ENST00000393925.3_Silent_p.T845T|PHLDB2_ENST00000393923.3_Silent_p.T829T	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	845						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GCAATTCCACGAATCTATCCC	0.478000													29	59					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119053036	119053036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119053036C>T	ENST00000409109.1	+	9	3175	c.2588C>T	c.(2587-2589)cCt>cTt	p.P863L	NLRX1_ENST00000409991.1_Missense_Mutation_p.P863L|NLRX1_ENST00000409265.4_Missense_Mutation_p.P863L|NLRX1_ENST00000292199.2_Missense_Mutation_p.P863L|NLRX1_ENST00000469103.2_3'UTR|NLRX1_ENST00000525863.1_Missense_Mutation_p.P863L			Q86UT6	NLRX1_HUMAN	NLR family member X1	863	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CGGGAGCACCCTTCCCTGGAA	0.637000													24	105					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46781659	46781659	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:46781659C>T	ENST00000394809.4	-	1	562	c.447G>A	c.(445-447)agG>agA	p.R149R	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	149					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GGCTGCCTCTCCTCCAGGGCA	0.667000													22	88					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100222168	100222168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:100222168G>A	ENST00000231461.5	-	3	692	c.382C>T	c.(382-384)Cta>Tta	p.L128L	ST8SIA4_ENST00000451528.2_Silent_p.L128L|ST8SIA4_ENST00000507360.2_5'UTR	NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	128					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		ACTTCAGGTAGGAGGCTATGT	0.438000													42	129					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325055	150325055	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150325055G>A	ENST00000328902.5	-	3	847	c.631C>T	c.(631-633)Caa>Taa	p.Q211*	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	211							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCTCGCAGTTGGGCCTCCTGC	0.537000													83	182					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81242165	81242165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81242165C>T	ENST00000599697.1	-	4	690	c.691G>A	c.(691-693)Gag>Aag	p.E231K	PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000337114.4_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	231	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AAGTAGGTCTCATCTGCTGCC	0.557000													9	70					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154841789	154841789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154841789C>T	ENST00000271915.3	-	1	967	c.652G>A	c.(652-654)Gag>Aag	p.E218K		NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	223						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			ATGACGATCTCCGGGGGGTTG	0.652000													31	58					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118969929	118969929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:118969929C>T	ENST00000515256.1	+	3	658	c.486C>T	c.(484-486)acC>acT	p.T162T				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	162						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						AAGAAGTGACCCTTTCTGAGG	0.517000													34	98					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100593733	100593733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100593733G>A	ENST00000471714.1	-	9	992	c.883C>T	c.(883-885)Cct>Tct	p.P295S	ABI3BP_ENST00000495063.1_Missense_Mutation_p.P295S|ABI3BP_ENST00000284322.5_Missense_Mutation_p.P295S			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	295						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						AGGGATGCAGGAAGTTTTACA	0.353000													7	14					0	0	1	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103599731	103599731	+	Silent	SNP	G	G	A	rs147415735	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103599731G>A	ENST00000560869.1	+	10	2217	c.1578G>A	c.(1576-1578)gtG>gtA	p.V526V	TNFAIP2_ENST00000538222.1_Silent_p.V9V|TNFAIP2_ENST00000451723.2_Silent_p.V195V|TNFAIP2_ENST00000333007.1_Silent_p.V526V			Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	526					angiogenesis|cell differentiation	extracellular space				NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	11		Melanoma(154;0.155)	Epithelial(46;0.191)			TGCACCTGGTGAAGGAGTACA	0.627000													18	62					0	0	1	0	0
C1orf85	112770	broad.mit.edu	37	1	156264762	156264762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156264762G>A	ENST00000362007.1	-	2	192	c.166C>T	c.(166-168)Ctg>Ttg	p.L56L	C1orf85_ENST00000368264.1_Intron|C1orf85_ENST00000472870.1_5'UTR	NM_001256604.1|NM_001256609.1|NM_144580.2	NP_001243533.1|NP_001243538.1|NP_653181.1	Q8WWB7	NCUG1_HUMAN	chromosome 1 open reading frame 85	56					positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(2)|prostate(2)|skin(3)	14	Hepatocellular(266;0.158)					ATATGAAGCAGGTTCTGCAGG	0.592000													6	42					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160431725	160431725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160431725C>T	ENST00000356956.1	+	4	569	c.421C>T	c.(421-423)Cct>Tct	p.P141S		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	141					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ATAGGGAACTCCTGAATTTGT	0.333000													21	34					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275341	71275341	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71275341T>A	ENST00000399575.2	+	3	470	c.296T>A	c.(295-297)tTt>tAt	p.F99Y	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	99	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				CCTCGACTCTTTCCGGGTTAT	0.418000													70	180					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175977	51175977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51175977G>A	ENST00000251020.4	-	2	189	c.156C>T	c.(154-156)ttC>ttT	p.F52F	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000440970.1_5'UTR	NM_002968.2	NP_002959.2	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	52					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ATAATTCAAAGAACTCGGCAC	0.453000													53	146					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092833	30092833	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30092833G>A	ENST00000567636.1	+	0	1208					NR_003558.1																						GGAGGGACGGGAAGTAGAGGA	0.423000													14	84					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926082	70926082	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70926082G>A	ENST00000603540.1	+	2	2124	c.1866G>A	c.(1864-1866)aaG>aaA	p.K622K	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Silent_p.K622K	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	622	Cys-rich.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCATCCATAAGAAGTGTGTCA	0.453000													12	90					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3740730	3740730	+	Silent	SNP	C	C	T	rs139746746	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3740730C>T	ENST00000541714.2	+	14	2274	c.1812C>T	c.(1810-1812)taC>taT	p.Y604Y	TJP3_ENST00000589378.1_Silent_p.Y613Y|TJP3_ENST00000539908.2_Silent_p.Y568Y|TJP3_ENST00000262968.9_Silent_p.Y637Y|TJP3_ENST00000382008.3_Silent_p.Y618Y|TJP3_ENST00000587686.1_Silent_p.Y623Y	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	618	Guanylate kinase-like.					tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGCCGCTACCCGCCCTACG	0.667000													12	32					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55614869	55614869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55614869C>T	ENST00000326258.1	+	1	61	c.61C>T	c.(61-63)Ccc>Tcc	p.P21S		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						TACAAACAACCCCGAGATGCA	0.373000													33	233					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138713209	138713209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138713209G>A	ENST00000389532.4	-	11	3362	c.3298C>T	c.(3298-3300)Cgt>Tgt	p.R1100C	CAMSAP1_ENST00000312405.6_Missense_Mutation_p.R822C|CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.R1111C	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	1100						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CTTCCGGAACGGGAATTCCGG	0.642000													15	37					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35801080	35801080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35801080C>T	ENST00000342694.2	+	7	1620	c.1365C>T	c.(1363-1365)acC>acT	p.T455T		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	455					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CACTTTCAACCCTGGCAATTG	0.507000													51	144					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854466	12854466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12854466G>A	ENST00000332296.7	+	3	793	c.690G>A	c.(688-690)gaG>gaA	p.E230E		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	230										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTGAAGGAGATGAAGAATC	0.418000													30	657					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107979316	107979316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:107979316C>T	ENST00000370068.1	+	7	2131	c.1285C>T	c.(1285-1287)Cat>Tat	p.H429Y	NTNG1_ENST00000370071.2_Intron|NTNG1_ENST00000370070.2_Intron|NTNG1_ENST00000370074.4_Intron|NTNG1_ENST00000370067.1_Intron|NTNG1_ENST00000370073.2_Missense_Mutation_p.H429Y|NTNG1_ENST00000370065.1_Intron|NTNG1_ENST00000542803.1_Missense_Mutation_p.H429Y|NTNG1_ENST00000370066.1_Intron|NTNG1_ENST00000370061.3_Missense_Mutation_p.H395Y|NTNG1_ENST00000370072.3_Intron			Q9Y2I2	NTNG1_HUMAN	netrin G1	429	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GGGCTCAATCCATGATCGTTG	0.478000													16	31					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84690161	84690161	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84690161G>A	ENST00000286744.5	+	26	4497		c.e26-1		ADAMTSL3_ENST00000567476.1_Splice_Site	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTTTCTGCAGAGCCTTTTTG	0.488000													13	206					0	0	1	0	0
TP53TG5	27296	broad.mit.edu	37	20	44004191	44004191	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44004191C>T	ENST00000372726.3	-	4	412	c.254_splice	c.e4-1	p.E86_splice	TP53TG5_ENST00000494455.1_5'UTR|SYS1-DBNDD2_ENST00000475242.1_Intron|SYS1-DBNDD2_ENST00000452133.1_Intron|SYS1_ENST00000426004.1_3'UTR|TP53TG5_ENST00000537995.1_Splice_Site_p.E70_splice	NM_014477.2	NP_055292.1	Q9Y2B4	T53G5_HUMAN	TP53 target 5	86					intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	12						GCACTGTTTTCCCTGGCAGGG	0.512000													52	144					0	0	1	0	0
MFGE8	4240	broad.mit.edu	37	15	89442993	89442993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89442993G>A	ENST00000539437.1	-	8	1032	c.896C>T	c.(895-897)gCc>gTc	p.A299V	MFGE8_ENST00000566497.1_Missense_Mutation_p.A307V|MFGE8_ENST00000542878.1_Missense_Mutation_p.A263V|MFGE8_ENST00000268151.7_Intron|MFGE8_ENST00000268150.8_Missense_Mutation_p.A307V			Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein	307	F5/8 type C 2.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	22	Lung NSC(78;0.0392)|all_lung(78;0.077)					AAAGTTACGGGCCCCCTGGGT	0.547000													28	41					0	0	1	0	0
IGLV3-22	28795	broad.mit.edu	37	22	23047198	23047198	+	RNA	SNP	G	G	A	rs149986188	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23047198G>A	ENST00000390307.2	+	0	300																											ATCCCTGAACGATTCTCTGGG	0.552000													9	46					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21235332	21235332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21235332G>A	ENST00000233242.1	-	26	4535	c.4408C>T	c.(4408-4410)Cat>Tat	p.H1470Y		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1470					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAGTCCAAATGAACTGAAGCA	0.403000													26	80					0	0	1	0	0
GATA2	2624	broad.mit.edu	37	3	128200709	128200709	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:128200709C>T	ENST00000341105.2	-	5	1427	c.1096G>A	c.(1096-1098)Ggg>Agg	p.G366R	GATA2_ENST00000489987.1_5'UTR|GATA2_ENST00000487848.1_Missense_Mutation_p.G366R|GATA2_ENST00000430265.2_Missense_Mutation_p.G352R	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	366					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		ACAGGGTCCCCGTTGGCGTTT	0.652000			Mis		AML(CML blast transformation)								19	49					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52942981	52942981	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52942981C>T	ENST00000354452.3	-	10	1269	c.658G>A	c.(658-660)Ggc>Agc	p.G220S	TCF4_ENST00000457482.3_Missense_Mutation_p.G60S|TCF4_ENST00000566279.1_Missense_Mutation_p.G160S|TCF4_ENST00000543082.1_Missense_Mutation_p.G178S|TCF4_ENST00000540999.1_Missense_Mutation_p.G196S|TCF4_ENST00000537856.3_Missense_Mutation_p.G90S|TCF4_ENST00000544241.2_Missense_Mutation_p.G149S|TCF4_ENST00000570287.2_Missense_Mutation_p.G60S|TCF4_ENST00000564403.2_Missense_Mutation_p.G226S|TCF4_ENST00000570177.2_Missense_Mutation_p.G90S|TCF4_ENST00000568740.1_Missense_Mutation_p.G195S|TCF4_ENST00000564228.1_Missense_Mutation_p.G149S|TCF4_ENST00000537578.1_Missense_Mutation_p.G196S|TCF4_ENST00000565018.2_Missense_Mutation_p.G220S|TCF4_ENST00000356073.4_Missense_Mutation_p.G220S|TCF4_ENST00000564999.1_Missense_Mutation_p.G220S|TCF4_ENST00000561992.1_Missense_Mutation_p.G90S|TCF4_ENST00000398339.1_Missense_Mutation_p.G322S|TCF4_ENST00000561831.3_Missense_Mutation_p.G60S|TCF4_ENST00000568673.1_Missense_Mutation_p.G196S|TCF4_ENST00000563760.1_5'UTR|TCF4_ENST00000566286.1_Missense_Mutation_p.G218S|TCF4_ENST00000567880.1_Missense_Mutation_p.G160S	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	220					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		CTGTGATGGCCATCTGTAAAG	0.463000													24	157					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50503243	50503243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50503243G>A	ENST00000301149.3	+	8	1223	c.991G>A	c.(991-993)Gag>Aag	p.E331K	GPD1_ENST00000548814.1_Missense_Mutation_p.E308K	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	331					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity	p.E331K(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	GGTGTGCTACGAGGGCCAGCC	0.572000													8	63					0	0	1	0	0
JMY	133746	broad.mit.edu	37	5	78608307	78608307	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78608307C>T	ENST00000396137.4	+	8	2512	c.2050C>T	c.(2050-2052)Cga>Tga	p.R684*	JMY_ENST00000412001.1_Intron	NM_152405.4	NP_689618.4	Q8N9B5	JMY_HUMAN	junction mediating and regulatory protein, p53 cofactor	684					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|urinary_tract(1)	16		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		GGATAGACTTCGAACATTTAA	0.303000													24	94					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37741779	37741779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37741779C>T	ENST00000400485.1	+	15	2189	c.2113C>T	c.(2113-2115)Ctt>Ttt	p.L705F	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	705					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						CCAGCTACTCCTTGTCACTGA	0.378000													25	76					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936978	15936978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:15936978G>A	ENST00000504595.1	+	4	1640	c.1159G>A	c.(1159-1161)Gag>Aag	p.E387K	FBXL7_ENST00000510662.1_Missense_Mutation_p.E340K|FBXL7_ENST00000329673.7_Missense_Mutation_p.E375K	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	387					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GAGGGGCTGCGAGGGCATCAC	0.617000													7	23					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118997857	118997857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:118997857C>T	ENST00000328252.3	+	7	3042	c.2673C>T	c.(2671-2673)gaC>gaT	p.D891D	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	891					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TGGTCCGGGACCCTCCTCTCC	0.502000													10	91					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600924	29600924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29600924G>A	ENST00000431530.3	+	1	2177	c.2119G>A	c.(2119-2121)Gag>Aag	p.E707K		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	697	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CAACCTCTATGAGAAATTCAA	0.542000													24	41					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89854724	89854724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:89854724G>A	ENST00000287908.3	+	2	721	c.328G>A	c.(328-330)Ggt>Agt	p.G110S	STEAP2_ENST00000402625.2_Missense_Mutation_p.G110S|STEAP2_ENST00000394622.2_Missense_Mutation_p.G110S|STEAP2_ENST00000394626.1_Missense_Mutation_p.G110S|STEAP2_ENST00000394632.1_Missense_Mutation_p.G110S|STEAP2_ENST00000394629.2_Missense_Mutation_p.G110S|STEAP2_ENST00000394621.2_Missense_Mutation_p.G110S	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	110					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					TCTGCTTGTGGGTAAAATCCT	0.378000													70	142					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32595760	32595760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32595760G>A	ENST00000286827.3	-	9	2428	c.1957C>T	c.(1957-1959)Cgc>Tgc	p.R653C	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Missense_Mutation_p.R653C	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	653					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						ATTCCAAGGCGGCCCATGGCC	0.483000													35	76					0	0	1	0	0
TEKT4	150483	broad.mit.edu	37	2	95540633	95540633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95540633G>A	ENST00000295201.4	+	4	963	c.826G>A	c.(826-828)Gac>Aac	p.D276N	AC097374.2_ENST00000568768.1_RNA	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	276					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						CATCCTTCGCGACACCTCCGA	0.687000													3	15					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386285	56386285	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56386285C>T	ENST00000355701.3	-	22	5218	c.4348G>A	c.(4348-4350)Ggt>Agt	p.G1450S	BZRAP1_ENST00000268893.6_Missense_Mutation_p.G1390S|BZRAP1_ENST00000343736.4_Missense_Mutation_p.G1450S	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1450						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGAGGCCACCCCTCTCCCGT	0.697000													23	45					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75157303	75157303	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:75157303A>T	ENST00000342232.4	-	4	1406	c.1366T>A	c.(1366-1368)Tat>Aat	p.Y456N		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	456					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CCTTTGCGATAAAAATGAGGA	0.483000													15	116					0	0	1	0	0
OLFML3	56944	broad.mit.edu	37	1	114523091	114523091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114523091C>T	ENST00000369551.1	+	3	480	c.192C>T	c.(190-192)tcC>tcT	p.S64S	OLFML3_ENST00000491700.1_3'UTR|OLFML3_ENST00000320334.4_Silent_p.S84S|OLFML3_ENST00000393300.2_Silent_p.S64S			Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3	84					multicellular organismal development	extracellular region				breast(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)|urinary_tract(1)	14	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACACCATCTCCGGGAGAGTGG	0.587000													14	79					0	0	1	0	0
LOC100505782	100505782	broad.mit.edu	37	17	39566079	39566079	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39566079C>T	ENST00000432258.1	+	0	1493				AC003958.2_ENST00000430006.1_RNA																							CACTTGGCTCCTTCCCATCCC	0.522000													5	23					0	0	1	0	0
PAX2	5076	broad.mit.edu	37	10	102584735	102584735	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102584735A>G	ENST00000370296.2	+	10	1717	c.1167A>G	c.(1165-1167)caA>caG	p.Q389Q	PAX2_ENST00000428433.1_Intron|PAX2_ENST00000556085.1_Intron|PAX2_ENST00000361791.3_Silent_p.Q366Q|PAX2_ENST00000355243.3_Intron			Q02962	PAX2_HUMAN	paired box 2	0					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CTTGTGTGCAACCCACTGTAT	0.617000													20	77					0	0	1	0	0
LAMP1	3916	broad.mit.edu	37	13	113973850	113973850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113973850C>T	ENST00000332556.4	+	5	823	c.629C>T	c.(628-630)cCc>cTc	p.P210L	LAMP1_ENST00000397181.3_Missense_Mutation_p.P157L	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	210	Hinge.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			AGCCCCTCGCCCTCACCCGTG	0.657000													19	51					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5069154	5069154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:5069154C>T	ENST00000381652.3	+	11	1953	c.1459C>T	c.(1459-1461)Cgc>Tgc	p.R487C	JAK2_ENST00000539801.1_Missense_Mutation_p.R487C|JAK2_ENST00000544510.1_Missense_Mutation_p.R338C	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	487					actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		GGAAACTGTTCGCTCAGACAA	0.338000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				26	46					0	0	1	0	0
PAX2	5076	broad.mit.edu	37	10	102584704	102584704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102584704G>A	ENST00000370296.2	+	10	1686	c.1136G>A	c.(1135-1137)aGg>aAg	p.R379K	PAX2_ENST00000428433.1_Intron|PAX2_ENST00000556085.1_Intron|PAX2_ENST00000361791.3_Missense_Mutation_p.R356K|PAX2_ENST00000355243.3_Intron			Q02962	PAX2_HUMAN	paired box 2	0					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		AAGCCGGGGAGGAAGCTTGCA	0.602000													36	78					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451910	138451910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138451910G>A	ENST00000344876.4	-	1	1719	c.1333C>T	c.(1333-1335)Ctc>Ttc	p.L445F	PCDH18_ENST00000507846.1_Missense_Mutation_p.L225F|PCDH18_ENST00000412923.2_Missense_Mutation_p.L445F|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	445	Cadherin 4.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ACTGTAGAGAGACTGGGTGTC	0.363000													53	124					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164733803	164733803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164733803G>A	ENST00000264382.3	-	32	3887	c.3825C>T	c.(3823-3825)ttC>ttT	p.F1275F		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1275	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GAAGGTCCTGGAATGCTTCAC	0.373000										HNSCC(35;0.089)			61	146					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204937936	204937936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204937936G>A	ENST00000367172.4	+	10	1157	c.829G>A	c.(829-831)Gac>Aac	p.D277N	NFASC_ENST00000513543.1_Missense_Mutation_p.D288N|NFASC_ENST00000338586.6_Missense_Mutation_p.D277N|NFASC_ENST00000367169.4_Missense_Mutation_p.D277N|NFASC_ENST00000360049.4_Missense_Mutation_p.D288N|NFASC_ENST00000367171.4_Missense_Mutation_p.D277N|NFASC_ENST00000401399.1_Missense_Mutation_p.D277N|NFASC_ENST00000539706.1_Missense_Mutation_p.D288N|NFASC_ENST00000403080.1_Missense_Mutation_p.D277N|NFASC_ENST00000367170.4_Missense_Mutation_p.D277N|NFASC_ENST00000339876.6_Missense_Mutation_p.D277N|NFASC_ENST00000404907.1_Missense_Mutation_p.D288N|NFASC_ENST00000404076.1_Missense_Mutation_p.D271N|NFASC_ENST00000338515.6_Missense_Mutation_p.D277N			O94856	NFASC_HUMAN	neurofascin	277	Ig-like C2-type 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCCAACACCAGACATCGCATG	0.493000													10	28					0	0	1	0	0
RORA	6095	broad.mit.edu	37	15	60919446	60919446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:60919446C>T	ENST00000261523.5	-	1	216	c.128G>A	c.(127-129)gGa>gAa	p.G43E	RORA_ENST00000309157.4_Missense_Mutation_p.G43E|RP11-219B17.1_ENST00000559824.1_RNA|RORA_ENST00000560004.1_Intron|RP11-219B17.1_ENST00000558235.1_RNA|RORA_ENST00000335670.6_Intron	NM_134260.2	NP_599022.1	P35398	RORA_HUMAN	RAR-related orphan receptor A	43	Modulating.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.G43K(1)		endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	21						ccttctggCTCCTTCACCTGC	0.537000													6	70					0	0	1	0	0
DYRK3	8444	broad.mit.edu	37	1	206821945	206821945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206821945C>T	ENST00000367106.1	+	4	1815	c.1342C>T	c.(1342-1344)Cgc>Tgc	p.R448C	DYRK3_ENST00000367108.3_Missense_Mutation_p.R448C|DYRK3_ENST00000367109.2_Missense_Mutation_p.R468C|DYRK3_ENST00000489878.1_Intron			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	468	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TGTGGGGGGTCGCTCACGTAG	0.522000													71	188					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72960115	72960115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:72960115G>A	ENST00000264839.7	+	13	2324	c.2324G>A	c.(2323-2325)gGa>gAa	p.G775E	RIMS1_ENST00000401910.3_Missense_Mutation_p.G249E|RIMS1_ENST00000348717.5_Missense_Mutation_p.G775E|RIMS1_ENST00000520567.1_Missense_Mutation_p.G775E|RIMS1_ENST00000523963.1_Missense_Mutation_p.G249E|RIMS1_ENST00000517960.1_Missense_Mutation_p.G775E|RIMS1_ENST00000521978.1_Missense_Mutation_p.G775E|RIMS1_ENST00000522291.1_Missense_Mutation_p.G775E|RIMS1_ENST00000517827.1_Missense_Mutation_p.G234E|RIMS1_ENST00000518273.1_Missense_Mutation_p.G775E|RIMS1_ENST00000491071.2_Missense_Mutation_p.G775E|RIMS1_ENST00000425662.2_Missense_Mutation_p.G168E			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	775	C2 1.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AGAGTAGATGGACGTCCTCGA	0.348000													9	19					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4925457	4925457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:4925457C>T	ENST00000333703.4	+	4	1073	c.560C>T	c.(559-561)cCt>cTt	p.P187L	PCDH11Y_ENST00000362095.5_Missense_Mutation_p.P198L|PCDH11Y_ENST00000215473.6_Missense_Mutation_p.P198L	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	198	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GCTGTTGATCCTGACGTAGGC	0.348000													42	29					0	0	1	0	0
ART1	417	broad.mit.edu	37	11	3681174	3681174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3681174G>A	ENST00000250693.1	+	3	526	c.425G>A	c.(424-426)cGg>cAg	p.R142Q		NM_004314.2	NP_004305.2	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1	142					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|skin(1)	8		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	GGCCGCTCCCGGGCCCACTAC	0.667000													26	49					0	0	1	0	0
ALKBH3	221120	broad.mit.edu	37	11	43923211	43923211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:43923211C>T	ENST00000302708.4	+	8	1016	c.605C>T	c.(604-606)cCc>cTc	p.P202L	ALKBH3_ENST00000532410.1_Intron	NM_139178.3	NP_631917.1	Q96Q83	ALKB3_HUMAN	alkB, alkylation repair homolog 3 (E. coli)	202	Fe2OG dioxygenase.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|kidney(1)|lung(4)|prostate(1)	8					Vitamin C(DB00126)	GGGAGGTGCCCCATTATTGCT	0.478000								Direct reversal of damage					33	46					0	0	1	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200819244	200819244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200819244C>T	ENST00000358823.2	+	11	3617	c.3347C>T	c.(3346-3348)tCc>tTc	p.S1116F	CAMSAP2_ENST00000236925.4_Missense_Mutation_p.S1127F|CAMSAP2_ENST00000413307.2_Missense_Mutation_p.S1100F	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	1127						cytoplasm|microtubule	protein binding										ATTGAAGTTTCCCTCTCAGAT	0.413000													63	115					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69027999	69027999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:69027999C>T	ENST00000288368.4	+	26	3435	c.3158C>T	c.(3157-3159)tCa>tTa	p.S1053L		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1053					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CTTCTGTCTTCAATAACATAT	0.338000													7	43					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35716442	35716442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:35716442C>T	ENST00000400445.3	+	18	2907	c.2373C>T	c.(2371-2373)ttC>ttT	p.F791F	NBEA_ENST00000310336.4_Silent_p.F791F|NBEA_ENST00000540320.1_Silent_p.F791F|NBEA_ENST00000379939.2_Silent_p.F791F	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	791						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATAGTCTTTTCACTCTTCTTG	0.368000													25	97					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179302048	179302048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179302048G>A	ENST00000356834.3	-	12	2077	c.2040C>T	c.(2038-2040)ccC>ccT	p.P680P	TBC1D9B_ENST00000355235.3_Silent_p.P680P	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	680	Rab-GAP TBC.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGCTCTCGAAGGGCATGACGC	0.607000													30	71					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183774774	183774774	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183774774C>T	ENST00000318351.1	+	5	535	c.501C>T	c.(499-501)ttC>ttT	p.F167F		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	167						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGGACATCTTCTACTTCCCTT	0.443000													18	271					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84778340	84778340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84778340C>T	ENST00000219473.7	+	4	366	c.253C>T	c.(253-255)Cct>Tct	p.P85S	USP10_ENST00000570191.1_Missense_Mutation_p.P89S|USP10_ENST00000562743.1_3'UTR	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	85	Interaction with p53/TP53.				DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						CACACTGAACCCTCAGGCCCC	0.463000													36	58					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769160	247769160	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247769160G>A	ENST00000320002.2	+	1	305	c.273G>A	c.(271-273)acG>acA	p.T91T	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CAAAGAAGACGATCACTTACG	0.463000													36	359					0	0	1	0	0
DNAJC3	5611	broad.mit.edu	37	13	96361519	96361519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:96361519C>T	ENST00000602402.1	+	2	238	c.121C>T	c.(121-123)Ctt>Ttt	p.L41F	DNAJC3_ENST00000376795.6_Missense_Mutation_p.L41F	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	41					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding			NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			TGAGAAACATCTTGAATTGGG	0.353000													24	78					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	871741	871741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:871741G>A	ENST00000316157.3	-	11	1235	c.1195C>T	c.(1195-1197)Cct>Tct	p.P399S		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	399							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						GAAGTCAGAGGAGACGCCGCA	0.468000													7	36					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331666	70331666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70331666G>A	ENST00000338508.4	-	32	4734	c.4735C>T	c.(4735-4737)Ccc>Tcc	p.P1579S	SHANK2_ENST00000423696.2_Missense_Mutation_p.P1199S|SHANK2_ENST00000409161.1_Missense_Mutation_p.P982S|SHANK2_ENST00000449833.2_Missense_Mutation_p.P983S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1199					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			gcgggcggggggATAACAAAG	0.572000													77	102					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55684615	55684615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55684615C>T	ENST00000370830.3	-	2	1219	c.521G>A	c.(520-522)cGa>cAa	p.R174Q	BMP5_ENST00000446683.2_Missense_Mutation_p.R174Q	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	174					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GTAATGCCTTCGCTGGTGAGA	0.378000													22	63					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106321130	106321130	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106321130C>T	ENST00000390559.2	-	0	858																											ATGCTGGCCTCACCCACGGCG	0.612000													10	28					0	0	1	0	0
IPMK	253430	broad.mit.edu	37	10	59956189	59956189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:59956189G>A	ENST00000373935.3	-	6	1221	c.899C>T	c.(898-900)tCc>tTc	p.S300F		NM_152230.4	NP_689416.1	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	300						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)	22						ATTAGCTGTGGAACTTAACAC	0.368000													27	123					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9014585	9014585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9014585C>T	ENST00000397910.4	-	31	38593	c.38390G>A	c.(38389-38391)gGc>gAc	p.G12797D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12799	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTTTGATGCCATTGGTCAG	0.557000													47	181					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16740853	16740853	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:16740853C>T	ENST00000381323.3	-	10	932	c.710_splice	c.e10-1	p.E238_splice	FAM49A_ENST00000406434.1_Splice_Site_p.E238_splice|FAM49A_ENST00000355549.2_Splice_Site_p.E238_splice	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	238						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			CTTCTGTACTCCCTGCAAGAG	0.502000													28	82					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136561642	136561642	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136561642C>T	ENST00000264162.2	-	11	4531	c.4521G>A	c.(4519-4521)gaG>gaA	p.E1507E		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1507	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGGTCTCATTCTCCCAGCCTC	0.517000													25	72					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137702101	137702101	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137702101G>A	ENST00000371817.3	+	44	3889	c.3474_splice	c.e44-1	p.G1159_splice		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1159	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTTCCCCTAGGGAGAGATCGG	0.567000													20	70					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36269678	36269678	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36269678C>T	ENST00000394571.2	+	6	816	c.816C>T	c.(814-816)ttC>ttT	p.F272F	PNPLA1_ENST00000388715.3_Silent_p.F177F|PNPLA1_ENST00000312917.5_Silent_p.F186F	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	272					lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						GAGTGATTTTCCCCCGGGTGG	0.517000											OREG0017382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	66					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160721144	160721144	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:160721144A>G	ENST00000274547.2	-	11	1700	c.1483T>C	c.(1483-1485)Ttc>Ctc	p.F495L	GABRB2_ENST00000517901.1_Missense_Mutation_p.F394L|GABRB2_ENST00000353437.6_Missense_Mutation_p.F457L|GABRB2_ENST00000517547.1_Missense_Mutation_p.F297L|GABRB2_ENST00000393959.1_Missense_Mutation_p.F495L|GABRB2_ENST00000520240.1_Missense_Mutation_p.F457L	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	495					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACCACTGGGAAGAATATGCGG	0.463000													30	73					0	0	1	0	0
WASF3	10810	broad.mit.edu	37	13	27256866	27256866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:27256866C>T	ENST00000361042.4	+	9	1322	c.1097C>T	c.(1096-1098)cCc>cTc	p.P366L	WASF3_ENST00000335327.5_Missense_Mutation_p.P369L			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	369					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CCCATGCAGCCCCCGTTCCCT	0.662000													8	126					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176675568	176675568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176675568G>A	ENST00000367662.3	+	10	4603	c.3439G>A	c.(3439-3441)Gaa>Aaa	p.E1147K		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1147					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGAGCTGGAGGAAGGTTTCAA	0.413000													16	48					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21607050	21607050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21607050C>T	ENST00000392288.2	+	4	1698	c.1589C>T	c.(1588-1590)tCa>tTa	p.S530L	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Missense_Mutation_p.S402L	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						AAACGATCTTCAACCCTTACT	0.348000													15	58					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46797278	46797278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46797278C>T	ENST00000230588.4	+	10	1123	c.1114C>T	c.(1114-1116)Cgc>Tgc	p.R372C		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	372	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			AGGCAATGTTCGCAAGTTGGT	0.488000													36	136					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	22078775	22078775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:22078775C>T	ENST00000382254.1	-	5	1097	c.11G>A	c.(10-12)aGg>aAg	p.R4K	CDH12_ENST00000504376.2_Missense_Mutation_p.R4K|CDH12_ENST00000522262.1_Missense_Mutation_p.R4K	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	4					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TAAACAGTTCCTTGTAAGCAT	0.463000										HNSCC(59;0.17)			31	28					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14769773	14769773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14769773G>A	ENST00000380881.4	-	28	5971	c.5156C>T	c.(5155-5157)aCc>aTc	p.T1719I	FREM1_ENST00000380894.1_Missense_Mutation_p.T254I|FREM1_ENST00000380880.3_Missense_Mutation_p.T1718I|FREM1_ENST00000486223.1_5'UTR|FREM1_ENST00000422223.2_Missense_Mutation_p.T1718I			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1718					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AAATTCCACGGTATCTGAATT	0.353000													15	12					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10753686	10753686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10753686G>A	ENST00000586078.1	+	22	2237	c.2128G>A	c.(2128-2130)Gag>Aag	p.E710K	SLC44A2_ENST00000335757.5_Intron|SLC44A2_ENST00000407327.4_Intron	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	0					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GGCAGAAGCCGAGGAGTAGAG	0.627000													8	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498050	179498050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179498050C>T	ENST00000589042.1	-	233	43174	c.42950G>A	c.(42949-42951)cGa>cAa	p.R14317Q	TTN_ENST00000342992.6_Missense_Mutation_p.R11749Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R12676Q|TTN_ENST00000342175.6_Missense_Mutation_p.R5444Q|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R5377Q|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R5252Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12676							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTATTAGTCGAGCTGAAAT	0.398000													13	170					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72363848	72363848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72363848C>T	ENST00000335666.4	+	1	252	c.204C>T	c.(202-204)ctC>ctT	p.L68L		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	68						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						GCTGGGACCTCCGAATAAGGC	0.552000													7	34					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10429970	10429970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10429970C>T	ENST00000397077.1	-	8	1473	c.898G>A	c.(898-900)Gac>Aac	p.D300N	ATP2B2_ENST00000383800.4_Missense_Mutation_p.D300N|ATP2B2_ENST00000360273.2_Missense_Mutation_p.D300N|ATP2B2_ENST00000352432.4_Missense_Mutation_p.D300N|ATP2B2_ENST00000343816.4_Missense_Mutation_p.D300N			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	300					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CCTTTTTTGTCTTTCTTCTCT	0.458000													31	232					0	0	1	0	0
SNAI1	6615	broad.mit.edu	37	20	48600619	48600619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:48600619C>T	ENST00000244050.2	+	2	402	c.341C>T	c.(340-342)tCc>tTc	p.S114F		NM_005985.3	NP_005976.2	O95863	SNAI1_HUMAN	snail family zinc finger 1	114					epithelial to mesenchymal transition|mesoderm formation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)	17			BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TCGTCCTTCTCCTCTACTTCA	0.632000													13	154					0	0	1	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27907940	27907940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27907940C>T	ENST00000326019.6	+	10	2194	c.1912C>T	c.(1912-1914)Cta>Tta	p.L638L		NM_018158.2	NP_060628.2	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger), member 1, adaptor protein	638						cytoplasm|nucleus	double-stranded RNA binding|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.155)					CCCTCCAACTCTAATGAGAAT	0.408000													17	103					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679639	100679639	+	Missense_Mutation	SNP	G	G	A	rs145386724		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100679639G>A	ENST00000306151.4	+	3	5006	c.4942G>A	c.(4942-4944)Gct>Act	p.A1648T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1648	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTCCTGAGGCTAGCACCCT	0.502000													131	515					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29407834	29407834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29407834C>T	ENST00000444197.2	+	1	752	c.42C>T	c.(40-42)ctC>ctT	p.L14L	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TTCTTCTTCTCGGCTTCTCCC	0.498000													8	75					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110835594	110835594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110835594G>A	ENST00000375820.4	-	27	2048	c.1927C>T	c.(1927-1929)Cct>Tct	p.P643S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	643	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGGTAAAGGAACAATTTTT	0.547000													6	29					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230589	36230589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36230589C>T	ENST00000303965.4	-	2	1009	c.520G>A	c.(520-522)Gac>Aac	p.D174N		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	174					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTAATATTGTCACTACCAAAT	0.363000													24	47					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2813223	2813223	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2813223G>A	ENST00000520002.1	-	65	10440	c.9885C>T	c.(9883-9885)ttC>ttT	p.F3295F	CSMD1_ENST00000542608.1_Silent_p.F3117F|CSMD1_ENST00000400186.3_Silent_p.F3118F|CSMD1_ENST00000602557.1_Silent_p.F3295F|CSMD1_ENST00000537824.1_Silent_p.F3294F|CSMD1_ENST00000602723.1_Silent_p.F3118F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3295	Sushi 28.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGGTGTAGCCGAAAGTAGGAA	0.502000													22	82					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39062705	39062705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39062705C>T	ENST00000355481.4	+	94	13909	c.13778C>T	c.(13777-13779)gCt>gTt	p.A4593V	RYR1_ENST00000359596.3_Missense_Mutation_p.A4598V|RYR1_ENST00000360985.3_Missense_Mutation_p.A4593V	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4598					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCTCAGCTGCTGGGGATGTG	0.602000													35	71					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60749489	60749489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60749489G>A	ENST00000303375.5	+	8	1839	c.1437G>A	c.(1435-1437)gaG>gaA	p.E479E		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	479	C-type lectin 2.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						ACAGTCTGGAGGACTGTGTCA	0.562000													40	101					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1255475	1255475	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1255475G>T	ENST00000310581.5	-	14	3141	c.3084C>A	c.(3082-3084)aaC>aaA	p.N1028K	TERT_ENST00000296820.5_3'UTR|TERT_ENST00000334602.6_Missense_Mutation_p.N965K	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	1028	CTE.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AAAATGTGGGGTTCTTCCAAA	0.557000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				8	48					1.06961e-07	1.07277e-07	1	1	0
TBC1D1	23216	broad.mit.edu	37	4	38091684	38091684	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:38091684A>T	ENST00000261439.4	+	13	2537	c.2182A>T	c.(2182-2184)Att>Ttt	p.I728F	TBC1D1_ENST00000508802.1_Missense_Mutation_p.I822F	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	728						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GCAAAAGGCTATTCTTCAACA	0.473000													11	135					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123301371	123301371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123301371G>A	ENST00000296513.2	+	3	332	c.147G>A	c.(145-147)atG>atA	p.M49I	ADAD1_ENST00000388725.2_Missense_Mutation_p.M31I|ADAD1_ENST00000388724.2_Missense_Mutation_p.M49I	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	49					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGTCCAAGATGGCATCCAAGG	0.453000													34	58					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38357230	38357230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38357230C>T	ENST00000379705.3	-	2	1098	c.241G>A	c.(241-243)Gag>Aag	p.E81K	TRPC4_ENST00000338947.5_Missense_Mutation_p.E81K|TRPC4_ENST00000358477.2_Missense_Mutation_p.E81K|TRPC4_ENST00000379681.3_Missense_Mutation_p.E81K|TRPC4_ENST00000447043.1_Missense_Mutation_p.E81K|TRPC4_ENST00000426868.2_Missense_Mutation_p.E81K|TRPC4_ENST00000379673.2_Missense_Mutation_p.E81K|TRPC4_ENST00000379679.1_Missense_Mutation_p.E81K|TRPC4_ENST00000355779.2_Missense_Mutation_p.E81K			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	81					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		tccaagttctcattttcaatt	0.373000													33	71					0	0	1	0	0
KRT16P4	339244	broad.mit.edu	37	17	18333049	18333049	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18333049G>A	ENST00000580052.1	+	0	43				KRT17P2_ENST00000326333.8_RNA																							GTGGAGATGGGCGCTGCCCCA	0.582000													21	17					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161049422	161049422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161049422G>A	ENST00000368012.3	-	2	699	c.397C>T	c.(397-399)Ccc>Tcc	p.P133S		NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	133	Ig-like V-type 1.				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTGCCGGCGGGGAAGGTGCTG	0.701000													11	18					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36564767	36564767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36564767G>A	ENST00000397799.1	-	4	739	c.515C>T	c.(514-516)cCt>cTt	p.P172L	COL8A2_ENST00000481785.1_Missense_Mutation_p.P107L|COL8A2_ENST00000303143.4_Missense_Mutation_p.P172L			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	172	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGTTTTCCAGGGATAGTAAT	0.716000													6	6					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23716293	23716293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23716293G>A	ENST00000256797.4	-	8	1077	c.909C>T	c.(907-909)ttC>ttT	p.F303F	ERN2_ENST00000457008.2_Silent_p.F255F	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	255					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GGAGGGCGAGGAAATGCAGAG	0.662000													15	66					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12343664	12343664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12343664C>T	ENST00000358136.3	+	21	5635	c.5505C>T	c.(5503-5505)atC>atT	p.I1835I	VPS13D_ENST00000356315.4_Silent_p.I1835I	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1835					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTTTTGGAATCGGCTCCACTG	0.483000													45	149					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41161881	41161881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41161881C>T	ENST00000263413.3	-	10	1636	c.1372G>A	c.(1372-1374)Gag>Aag	p.E458K	C6_ENST00000337836.5_Missense_Mutation_p.E458K|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	458	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTCCCTTTCTCCCATGCCAAA	0.428000													27	86					0	0	1	0	0
SNX5	27131	broad.mit.edu	37	20	17934726	17934726	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:17934726A>G	ENST00000377768.3	-	5	615	c.303T>C	c.(301-303)ggT>ggC	p.G101G	SNX5_ENST00000377759.4_Silent_p.G101G|SNX5_ENST00000483485.1_5'UTR	NM_152227.1	NP_689413.1	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	101	PX.|Phosphatidylinositol bisphosphate binding (By similarity).				cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	11						TCTCTCGAGGACCATCAAAGT	0.493000													62	174					0	0	1	0	0
OXTR	5021	broad.mit.edu	37	3	8794753	8794753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:8794753C>T	ENST00000316793.3	-	4	1704	c.1080G>A	c.(1078-1080)acG>acA	p.T360T	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	360					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	TGCTGGCACTCGTCTCTCCCA	0.622000													29	50					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057615	9057615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9057615G>A	ENST00000397910.4	-	3	30034	c.29831C>T	c.(29830-29832)tCc>tTc	p.S9944F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9946	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATGGATGAGGAAGAGAGCCT	0.453000													85	231					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2614040	2614040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2614040G>A	ENST00000399655.1	+	8	1411	c.1146G>A	c.(1144-1146)tgG>tgA	p.W382*	CACNA1C_ENST00000347598.4_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399591.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000480911.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000344100.3_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399597.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000335762.5_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399595.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399603.1_Intron|CACNA1C_ENST00000399617.1_Intron|CACNA1C_ENST00000399606.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399621.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399601.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399638.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399649.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399644.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399629.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000327702.7_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000399637.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000491104.1_Intron|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000402845.3_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399641.1_Intron	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	382					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACTGGCCCTGGATCTATTTTG	0.498000													8	29					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53930377	53930377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53930377C>T	ENST00000371445.3	+	3	873	c.818C>T	c.(817-819)cCc>cTc	p.P273L		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	273	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						ccactgccgccCCTTCCACCG	0.682000													27	46					0	0	1	0	0
SUSD3	203328	broad.mit.edu	37	9	95847007	95847007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95847007C>T	ENST00000375472.3	+	5	782	c.746C>T	c.(745-747)cCc>cTc	p.P249L	SUSD3_ENST00000375469.1_Missense_Mutation_p.P236L	NM_145006.2	NP_659443.1	Q96L08	SUSD3_HUMAN	sushi domain containing 3	249						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	13						CCACAACAGCCCGCAGCATAT	0.647000													26	80					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15567435	15567435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15567435G>A	ENST00000343625.6	-	10	1534	c.1454C>T	c.(1453-1455)aCt>aTt	p.T485I	RASAL3_ENST00000595098.1_5'UTR	NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	485	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						CAGCTCCGCAGTGCCCAGGTC	0.607000													7	17					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233514953	233514953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233514953C>T	ENST00000366624.3	+	9	2462	c.2201C>T	c.(2200-2202)gCt>gTt	p.A734V	MLK4_ENST00000366622.1_Missense_Mutation_p.A180V	NM_032435.2	NP_115811.2																					GCATCGGTGGCTCTGGGACTG	0.527000													25	70					0	0	1	0	0
SLC10A7	84068	broad.mit.edu	37	4	147227087	147227087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:147227087G>A	ENST00000432059.2	-	6	753	c.507C>T	c.(505-507)atC>atT	p.I169I	SLC10A7_ENST00000264986.3_3'UTR|SLC10A7_ENST00000335472.7_Silent_p.I182I|SLC10A7_ENST00000394062.3_Silent_p.I182I|SLC10A7_ENST00000507030.1_Silent_p.I182I			Q0GE19	NTCP7_HUMAN	solute carrier family 10, member 7	182						integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|skin(1)	16	all_hematologic(180;0.151)					CCTGTCCAATGATGAGAGGAA	0.358000													9	26					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30963185	30963185	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30963185G>A	ENST00000311813.4	+	4	806	c.751G>A	c.(751-753)Gag>Aag	p.E251K	AQP1_ENST00000434909.2_Missense_Mutation_p.E311K|AQP1_ENST00000441328.2_Missense_Mutation_p.E168K|AQP1_ENST00000409899.1_Missense_Mutation_p.E136K|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Missense_Mutation_p.E200K|AQP1_ENST00000509504.1_Missense_Mutation_p.E428K	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				CGGCCAGGTGGAGGAGTATGA	0.627000													8	23					0	0	1	0	0
ATXN7L3	56970	broad.mit.edu	37	17	42274671	42274671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42274671G>A	ENST00000389384.4	-	3	589	c.281C>T	c.(280-282)gCc>gTc	p.A94V	ATXN7L3_ENST00000593073.1_Intron|ATXN7L3_ENST00000454077.2_Missense_Mutation_p.A94V	NM_001098833.1	NP_001092303.1	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3	94					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCGGGAGGCGGCAATGCTGCG	0.597000													53	51					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1254125	1254125	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1254125C>T	ENST00000348261.5	+	10	2366	c.2118C>T	c.(2116-2118)gcC>gcT	p.A706A	CACNA1H_ENST00000565831.1_Silent_p.A706A|CACNA1H_ENST00000358590.4_Silent_p.A706A	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	706					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCACCCGTGCCCTGGAGGACC	0.672000													4	14					0	0	1	0	0
SCAMP3	10067	broad.mit.edu	37	1	155227093	155227093	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155227093G>T	ENST00000355379.3	-	6	962	c.684C>A	c.(682-684)atC>atA	p.I228I	SCAMP3_ENST00000302631.3_Silent_p.I254I|SCAMP3_ENST00000472397.1_5'UTR	NM_052837.2	NP_443069.1	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3	254					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(7)|ovary(4)|urinary_tract(1)	19	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCCAACCTGGGATACCAATGG	0.463000													8	23					1.76689e-08	1.77279e-08	1	1	0
PBX4	80714	broad.mit.edu	37	19	19681593	19681593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19681593G>A	ENST00000251203.8	-	3	529	c.243C>T	c.(241-243)ctC>ctT	p.L81L		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	81							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						CCAGCCTCAGGAGCTGGGCGT	0.572000													32	70					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804545	115804545	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115804545C>T	ENST00000369295.2	+	1	740	c.654C>T	c.(652-654)ttC>ttT	p.F218F		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	218	Agonist and antagonist binding (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	GCTGCGACTTCGTCACCAACC	0.662000													11	48					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43814059	43814059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43814059C>T	ENST00000382031.1	+	5	1133	c.1102C>T	c.(1102-1104)Cct>Tct	p.P368S	MAP1A_ENST00000399453.1_Missense_Mutation_p.P130S|MAP1A_ENST00000300231.5_Missense_Mutation_p.P130S			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	130	Lys-rich (basic).					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCTTATCTCTCCTGAGCTTGG	0.552000													30	67					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671263	39671263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39671263C>T	ENST00000398930.1	+	4	434	c.80C>T	c.(79-81)cCc>cTc	p.P27L	KCNJ15_ENST00000398938.2_Missense_Mutation_p.P27L|KCNJ15_ENST00000398932.1_Missense_Mutation_p.P27L|KCNJ15_ENST00000398934.1_Missense_Mutation_p.P27L|KCNJ15_ENST00000328656.3_Missense_Mutation_p.P27L			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	27					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						GCCAACAGACCCCGCGTCATG	0.552000													26	50					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94754660	94754660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94754660C>T	ENST00000554723.1	-	3	1493	c.1075G>A	c.(1075-1077)Gac>Aac	p.D359N	SERPINA10_ENST00000554173.1_Missense_Mutation_p.D319N|SERPINA10_ENST00000393096.1_Missense_Mutation_p.D319N|SERPINA10_ENST00000261994.4_Missense_Mutation_p.D319N			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	319					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TCCACCAAGTCTGTGGTCAGG	0.502000													11	94					0	0	1	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995648	57995648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57995648G>A	ENST00000316770.2	-	1	742	c.700C>T	c.(700-702)Cgt>Tgt	p.R234C		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				TCGGCAGAACGGATGCTCAGG	0.627000													20	47					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340778	121340778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121340778G>A	ENST00000338040.4	+	3	916	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	168					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		CAGTGTGGAGGAAATGGGAGG	0.488000													15	38					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57290234	57290234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:57290234C>T	ENST00000543872.2	+	4	2314	c.2050C>T	c.(2050-2052)Cct>Tct	p.P684S	CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.P684S|SMG8_ENST00000580498.1_3'UTR			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	684					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						AGAAAAAGAACCTCAAACCCA	0.468000													56	186					0	0	1	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39388084	39388084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39388084C>T	ENST00000402182.3	+	7	1119	c.1064C>T	c.(1063-1065)cCc>cTc	p.P355L	APOBEC3B-AS1_ENST00000513758.2_RNA|APOBEC3B_ENST00000333467.3_Missense_Mutation_p.P355L|APOBEC3B_ENST00000407298.3_Missense_Mutation_p.P330L			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	355					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					CAGGGATGTCCCTTCCAGCCC	0.617000													17	41					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879303	3879303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3879303C>T	ENST00000315677.3	-	4	1361	c.766G>A	c.(766-768)Gac>Aac	p.D256N	DLGAP1-AS3_ENST00000577649.1_RNA|DLGAP1_ENST00000581527.1_Missense_Mutation_p.D256N|DLGAP1_ENST00000515196.2_Missense_Mutation_p.D256N|DLGAP1_ENST00000584874.1_Missense_Mutation_p.D256N	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	256					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CACTTGACGTCGTTGTTGCTC	0.672000													17	51					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638207	234638207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234638207C>T	ENST00000482026.1	+	1	454	c.435C>T	c.(433-435)tcC>tcT	p.S145S	UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000373445.1_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		ATGCTACTTCCTTTGATGTGG	0.448000													90	232					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118969872	118969872	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:118969872G>A	ENST00000515256.1	+	3	601	c.429G>A	c.(427-429)tgG>tgA	p.W143*				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	143						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						CTGTCTCCTGGGAGACAGAGG	0.463000													36	67					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156430	70156430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70156430C>T	ENST00000335568.5	+	5	1213	c.1211C>T	c.(1210-1212)gCt>gTt	p.A404V	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	404					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GATAACATTGCTCACATGAAG	0.453000													21	85					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170897468	170897468	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170897468T>C	ENST00000272793.5	+	32	4683	c.4633T>C	c.(4633-4635)Tta>Cta	p.L1545L	UBR3_ENST00000418381.1_Silent_p.L1545L|UBR3_ENST00000392631.1_Silent_p.L366L			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1545					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						CATCCAGATCTTAATGATGCC	0.328000													8	75					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155506871	155506871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155506871G>A	ENST00000302053.3	-	5	1788	c.1710C>T	c.(1708-1710)ttC>ttT	p.F570F	FGA_ENST00000403106.3_Silent_p.F570F	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	570					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CACGGGAAGGGAATTCAGCTA	0.428000													39	89					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2539368	2539368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2539368G>A	ENST00000358864.1	+	3	364	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	117	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CCCAAAGAGGGAAAAGGAGAT	0.652000													4	25					0	0	1	0	0
GRINA	2907	broad.mit.edu	37	8	145066418	145066418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145066418C>T	ENST00000313269.5	+	5	977	c.699C>T	c.(697-699)gtC>gtT	p.V233V	GRINA_ENST00000395068.4_Silent_p.V233V	NM_000837.1	NP_000828.1	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	233						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	9	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCAGTCGGTCCTGACCGCCA	0.627000													18	41					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79842818	79842818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:79842818C>T	ENST00000261205.4	+	11	1840	c.1183C>T	c.(1183-1185)Ctg>Ttg	p.L395L	RP1-78O14.1_ENST00000550268.1_lincRNA|SYT1_ENST00000552744.1_Silent_p.L395L|SYT1_ENST00000393240.3_Silent_p.L395L|SYT1_ENST00000457153.2_Silent_p.L392L	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	395					detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						GTCAGACATGCTGGCCAACCC	0.547000													17	39					0	0	1	0	0
WHAMM	123720	broad.mit.edu	37	15	83499448	83499448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83499448C>T	ENST00000286760.4	+	9	1838	c.1739C>T	c.(1738-1740)tCc>tTc	p.S580F		NM_001080435.1	NP_001073904.1	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi membranes and microtubules	580						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding			endometrium(6)|large_intestine(5)|lung(1)|prostate(1)	13						TTGCCAGCTTCCCACGCGGTG	0.512000													16	197					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31337958	31337958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31337958G>A	ENST00000215862.4	-	9	1795	c.432C>T	c.(430-432)ctC>ctT	p.L144L	MORC2_ENST00000397641.2_Silent_p.L206L|MORC2_ENST00000469915.1_5'UTR	NM_014941.1	NP_055756.1	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	206							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						CATTATCCATGAGTTTGAGAT	0.498000													61	125					0	0	1	0	0
BMP10	27302	broad.mit.edu	37	2	69093153	69093153	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69093153C>T	ENST00000295379.1	-	2	1043	c.885G>A	c.(883-885)ggG>ggA	p.G295G		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	295					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						AAGCCTCTTCCCCAGGTCCAC	0.493000													18	65					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952897	119952897	+	Silent	SNP	C	C	T	rs145945905		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119952897C>T	ENST00000307142.4	+	4	3163	c.2967C>T	c.(2965-2967)ccC>ccT	p.P989P	SYNPO2_ENST00000429713.2_Silent_p.P989P|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Silent_p.P989P	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	989						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ATGGCCTCCCCCAGAAGTCAT	0.512000													5	60					0	0	1	0	0
ADCK2	90956	broad.mit.edu	37	7	140380881	140380881	+	Missense_Mutation	SNP	C	C	T	rs138501789		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:140380881C>T	ENST00000072869.4	+	4	1427	c.1249C>T	c.(1249-1251)Ccc>Tcc	p.P417S	ADCK2_ENST00000476491.1_Missense_Mutation_p.P417S	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	417	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					GGCAGGAATTCCCGTGGACTT	0.567000													5	53					0	0	1	0	0
SPIB	6689	broad.mit.edu	37	19	50926223	50926223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50926223G>A	ENST00000595883.1	+	4	293	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K	SPIB_ENST00000596074.1_Intron|SPIB_ENST00000439922.2_Intron|SPIB_ENST00000270632.7_Missense_Mutation_p.E90K|SPIB_ENST00000597855.1_Missense_Mutation_p.E90K	NM_001243999.1|NM_001244000.1|NM_003121.4	NP_001230928.1|NP_001230929.1|NP_003112.2	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	90					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)	14		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AGGGAACCTCGAACTGGCCCC	0.642000													35	116					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61828635	61828635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61828635C>T	ENST00000280772.1	-	37	12195	c.12004G>A	c.(12004-12006)Gga>Aga	p.G4002R	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4002					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCACTAATTCCCTTAAAATAT	0.433000													65	146					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15937163	15937163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:15937163C>T	ENST00000504595.1	+	4	1825	c.1344C>T	c.(1342-1344)atC>atT	p.I448I	FBXL7_ENST00000510662.1_Silent_p.I401I|FBXL7_ENST00000329673.7_Silent_p.I436I	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	448					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GCTTGCAGATCGTGGCCGCCA	0.627000													4	41					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115986838	115986838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115986838G>A	ENST00000251864.2	+	23	3336	c.3183G>A	c.(3181-3183)atG>atA	p.M1061I	TDRD1_ENST00000422662.1_Intron|TDRD1_ENST00000369281.2_Missense_Mutation_p.M947I|TDRD1_ENST00000369282.1_Intron|TDRD1_ENST00000369280.1_Intron	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	1061					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CAGGATTAATGGAATTGAATG	0.264000													5	16					0	0	1	0	0
PCDHB17P	54661	broad.mit.edu	37	5	140537091	140537091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140537091C>T	ENST00000539533.1	+	1	1515	c.1515C>T	c.(1513-1515)gtC>gtT	p.V505V																								CCTCCCTGGTCTCCATCAACA	0.652000													58	197					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104508525	104508525	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104508525G>A	ENST00000409874.4	+	34	4022		c.e34+1		TDRD9_ENST00000339063.5_Splice_Site	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9						cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				AGCTTTTAGGGTAAGCTGTGT	0.463000													20	34					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118865121	118865121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:118865121G>A	ENST00000295622.1	+	1	125	c.85G>A	c.(85-87)Ggc>Agc	p.G29S		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	29										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		CCACACTAAGGGCCAGGAAGA	0.567000													15	36					0	0	1	0	0
HCN3	57657	broad.mit.edu	37	1	155258222	155258222	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155258222C>T	ENST00000368358.3	+	8	2301	c.2293C>T	c.(2293-2295)Ccc>Tcc	p.P765S	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	765	Pro-rich.					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCCAGCCACACCCCGGGGTCT	0.587000													7	95					0	0	1	0	0
CCDC102A	92922	broad.mit.edu	37	16	57552561	57552561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57552561C>T	ENST00000258214.2	-	5	1260	c.1014G>A	c.(1012-1014)cgG>cgA	p.R338R		NM_033212.3	NP_149989.2	Q96A19	C102A_HUMAN	coiled-coil domain containing 102A	338										endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8						CGGCCATTTTCCGGTCCATGC	0.652000													8	27					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121492935	121492935	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121492935G>A	ENST00000260197.7	+	45	6258	c.6129G>A	c.(6127-6129)tgG>tgA	p.W2043*	SORL1_ENST00000527934.1_Nonsense_Mutation_p.W658*|SORL1_ENST00000525532.1_Nonsense_Mutation_p.W987*|SORL1_ENST00000532694.1_Nonsense_Mutation_p.W889*|SORL1_ENST00000534286.1_Nonsense_Mutation_p.W953*	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2043	Fibronectin type-III 6.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTCTGTTTTGGAAAAGCCTGG	0.353000													20	55					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905628	15905628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15905628C>T	ENST00000308940.8	+	1	868	c.770C>T	c.(769-771)tCc>tTc	p.S257F		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						GGCTTTGCCTCCGTCATTTAC	0.572000													18	51					0	0	1	0	0
CRCT1	54544	broad.mit.edu	37	1	152487946	152487946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152487946C>T	ENST00000368790.3	+	2	160	c.87C>T	c.(85-87)ccC>ccT	p.P29P		NM_019060.2	NP_061933.1	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	29										lung(1)|ovary(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ccccggcgcccaccccggcgc	0.716000													3	23					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973335	29973335	+	Nonsense_Mutation	SNP	C	C	T	rs144365564	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:29973335C>T	ENST00000378993.1	+	11	2162	c.1489C>T	c.(1489-1491)Cga>Tga	p.R497*	IL1RAPL1_ENST00000302196.4_Nonsense_Mutation_p.R497*	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	497	TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						AACCAGACTTCGAAATATGCT	0.443000													38	43					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197298127	197298127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197298127C>T	ENST00000260983.2	-	2	203	c.21G>A	c.(19-21)gaG>gaA	p.E7E		NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	7					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						AAAGCAGGTGCTCCCGGGCTG	0.522000													21	53					0	0	1	0	0
BZRAP1-AS1	100506779	broad.mit.edu	37	17	56408651	56408651	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56408651C>T	ENST00000579527.1	+	0	351				MIR142_ENST00000579003.1_RNA|BZRAP1-AS1_ENST00000580515.1_RNA|BZRAP1-AS1_ENST00000580633.1_RNA|BZRAP1-AS1_ENST00000578334.1_RNA|MIR142_ENST00000384835.1_RNA																							GTTAGTAGTGCTTTCTACTTT	0.587000													14	56					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197396914	197396914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197396914C>T	ENST00000367397.1	+	3	1460	c.602C>T	c.(601-603)tCt>tTt	p.S201F	CRB1_ENST00000544212.1_Missense_Mutation_p.S301F|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.S708F|CRB1_ENST00000535699.1_Missense_Mutation_p.S751F|CRB1_ENST00000367400.3_Missense_Mutation_p.S820F			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	820	EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATTTCTGCTTCTACGTGGAAA	0.373000													14	42					0	0	1	0	0
GH1	2688	broad.mit.edu	37	17	61994690	61994690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61994690C>T	ENST00000323322.5	-	5	675	c.633G>A	c.(631-633)gtG>gtA	p.V211V	GH1_ENST00000458650.2_Silent_p.V196V|GH1_ENST00000342364.4_Silent_p.V116V|GH1_ENST00000351388.4_Silent_p.V171V|CSHL1_ENST00000392824.4_Intron	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	211					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						AGCTGCCCTCCACAGAGCGGC	0.617000													20	41					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498290	179498290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179498290C>T	ENST00000589042.1	-	232	43020	c.42796G>A	c.(42796-42798)Ggt>Agt	p.G14266S	TTN_ENST00000342992.6_Missense_Mutation_p.G11698S|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G12625S|TTN_ENST00000342175.6_Missense_Mutation_p.G5393S|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G5326S|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G5201S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12625	Fibronectin type-III 3.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCTTCACCATCTTTGAAC	0.408000													20	45					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31656616	31656616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31656616G>A	ENST00000375494.3	+	10	986	c.986G>A	c.(985-987)gGg>gAg	p.G329E		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	329					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										CAGGCCCTGGGGAAGCTGCCC	0.582000													15	47					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665948	19665948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19665948G>A	ENST00000328041.6	+	12	1464	c.1267G>A	c.(1267-1269)Gag>Aag	p.E423K		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	423	Poly-Glu.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						gaatgatgaggaggaagagga	0.527000													14	54					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52000654	52000654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52000654C>T	ENST00000291707.3	-	6	1506	c.1451G>A	c.(1450-1452)gGa>gAa	p.G484E	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.G366E	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	484					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGCTCCAGCTCCCCCGAATGC	0.567000													37	100					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887076	3887076	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3887076C>T	ENST00000319331.3	+	2	1512	c.751C>T	c.(751-753)Ctg>Ttg	p.L251L	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	251						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TGATAACAAACTGGTTAAAGT	0.403000													53	142					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10106264	10106264	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10106264T>A	ENST00000264828.3	-	16	1648	c.1563A>T	c.(1561-1563)ggA>ggT	p.G521G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	521	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGCCAGGGGGTCCATGAGGTC	0.507000													14	37					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179429682	179429682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179429682C>T	ENST00000589042.1	-	326	81401	c.81177G>A	c.(81175-81177)ctG>ctA	p.L27059L	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Silent_p.L24491L|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Silent_p.L25418L|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Silent_p.L18186L|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.L18119L|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.L17994L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25418	Fibronectin type-III 97.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTAGAATCCAGTGGGGCAC	0.383000													40	129					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89733119	89733119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89733119C>T	ENST00000343435.5	-	5	945	c.409G>A	c.(409-411)Ggt>Agt	p.G137S	RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000370459.3_Missense_Mutation_p.G137S	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	137						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		TCGATAGCACCCTGATCAATT	0.453000													19	45					0	0	1	0	0
OR2V2	285659	broad.mit.edu	37	5	180582584	180582584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180582584C>T	ENST00000328275.1	+	1	642	c.642C>T	c.(640-642)atC>atT	p.I214I		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATTCTCCATCATCGTGGCCT	0.517000													27	205					0	0	1	0	0
NXPH1	30010	broad.mit.edu	37	7	8790865	8790865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:8790865C>T	ENST00000405863.1	+	3	1193	c.282C>T	c.(280-282)tcC>tcT	p.S94S	NXPH1_ENST00000497400.1_3'UTR|NXPH1_ENST00000602349.1_5'UTR	NM_152745.2	NP_689958.1	P58417	NXPH1_HUMAN	neurexophilin 1	94	II.					extracellular region				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|ovary(1)	17		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		TGAGGAACTCCACAGACCTTC	0.478000													20	65					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127235596	127235596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127235596C>T	ENST00000265825.5	+	2	599	c.380C>T	c.(379-381)tCc>tTc	p.S127F	FSCN3_ENST00000420086.2_5'UTR	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	127						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						TTTTGCACTTCCCACGTCCTC	0.572000													16	42					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113803686	113803686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113803686G>A	ENST00000260191.2	+	6	824	c.567G>A	c.(565-567)agG>agA	p.R189R	HTR3B_ENST00000537778.1_Silent_p.R178R	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	189					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CCTTTCTGAGGAGCCCAGAAG	0.483000													21	48					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71851671	71851671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71851671G>A	ENST00000373255.4	+	4	702	c.438G>A	c.(436-438)ggG>ggA	p.G146G		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	146	Lys-rich.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						AGAAGGGGGGGAAGAAATCCA	0.587000													18	56					0	0	1	0	0
GLT6D1	360203	broad.mit.edu	37	9	138518016	138518016	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138518016G>A	ENST00000371763.1	-	4	409	c.156C>T	c.(154-156)ctC>ctT	p.L52L		NM_182974.2	NP_892019.2	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	52					carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	15		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		GGACAGGAGCGAGCCAGTCTG	0.532000													16	66					0	0	1	0	0
CRYBG3	131544	broad.mit.edu	37	3	97596782	97596782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97596782C>T	ENST00000182096.4	+	1	964	c.900C>T	c.(898-900)tcC>tcT	p.S300S		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						AAAGTCATTCCTCAGAAAAAG	0.403000													9	98					0	0	1	0	0
CELA1	1990	broad.mit.edu	37	12	51736476	51736476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51736476G>A	ENST00000293636.1	-	4	249	c.209C>T	c.(208-210)aCt>aTt	p.T70I		NM_001971.5	NP_001962.3	Q9UNI1	CELA1_HUMAN	chymotrypsin-like elastase family, member 1	70	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15						CACGCGGAAAGTCTTCTGGCT	0.493000													11	37					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45829220	45829220	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:45829220G>A	ENST00000263736.4	-	3	145	c.83C>T	c.(82-84)tCa>tTa	p.S28L		NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	28					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGAGGCAGATGATCTAGAAGT	0.398000													36	92					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911020	230911020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230911020C>T	ENST00000295190.4	-	4	1280	c.822G>A	c.(820-822)agG>agA	p.R274R		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	274						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		ACATGTTCTTCCTGTGCCCGG	0.592000													42	92					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107038	121107038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:121107038C>T	ENST00000295228.3	+	2	858	c.812C>T	c.(811-813)tCg>tTg	p.S271L		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	271					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				GGCGAAGAGTCGCACCGGCCC	0.662000													17	94					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61843269	61843269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61843269C>T	ENST00000280772.1	-	33	4372	c.4181G>A	c.(4180-4182)aGa>aAa	p.R1394K	ANK3_ENST00000355288.2_Missense_Mutation_p.R528K|ANK3_ENST00000503366.1_Missense_Mutation_p.R1395K|ANK3_ENST00000373827.2_Missense_Mutation_p.R1388K	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1394					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AAATGGCAGTCTATTTTCTTT	0.303000													16	72					0	0	1	0	0
TRAV8-1	28685	broad.mit.edu	37	14	22265829	22265829	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22265829C>T	ENST00000390430.2	+	0	244																											AGCAGCCTCACTGGAGTTGGG	0.453000													23	179					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140615792	140615792	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140615792G>A	ENST00000526308.1	+	0	1855					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						GGACGCCAACGACAACTCGCC	0.711000													34	64					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155506994	155506994	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155506994G>A	ENST00000302053.3	-	5	1665	c.1587C>T	c.(1585-1587)ttC>ttT	p.F529F	FGA_ENST00000403106.3_Silent_p.F529F	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	529					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGAAACCTGGGAATGTTTTTC	0.473000													26	70					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184141	6184141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6184141C>T	ENST00000262450.3	-	31	4665	c.4566G>A	c.(4564-4566)ggG>ggA	p.G1522G	CHD5_ENST00000378021.1_Silent_p.G379G	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1522					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGCTGTACTTCCCGTTGACAT	0.632000													8	21					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37000603	37000603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:37000603C>T	ENST00000282516.8	+	12	3932	c.3433C>T	c.(3433-3435)Cgt>Tgt	p.R1145C	NIPBL_ENST00000448238.2_Missense_Mutation_p.R1145C	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1145					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGGTGGTGGTCGTTATCGAAA	0.463000													18	110					0	0	1	0	0
TMEM63C	57156	broad.mit.edu	37	14	77719701	77719701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77719701C>T	ENST00000298351.4	+	23	2346	c.2202C>T	c.(2200-2202)tcC>tcT	p.S734S		NM_020431.2	NP_065164.2	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	734						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(1)	23			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		GCAGCACCTCCTCCACGCCCA	0.617000													5	16					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134968307	134968307	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134968307C>T	ENST00000398015.3	+	15	3190	c.2820C>T	c.(2818-2820)ctC>ctT	p.L940L	EPHB1_ENST00000493838.1_Silent_p.L501L	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	940	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TCACCTCCCTCCAGCTGGTCA	0.547000													11	89					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102742658	102742658	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102742658C>T	ENST00000532855.1	-	0	471							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CCTCACGGTTCATGTCAGGTG	0.388000													9	22					0	0	1	0	0
NMNAT3	349565	broad.mit.edu	37	3	139346559	139346559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:139346559C>T	ENST00000413939.2	-	3	408	c.8G>A	c.(7-9)aGc>aAc	p.S3N	NMNAT3_ENST00000296202.7_Missense_Mutation_p.S3N|NMNAT3_ENST00000406824.1_5'UTR|NMNAT3_ENST00000406164.1_5'UTR|NMNAT3_ENST00000339837.5_Intron|NMNAT3_ENST00000511444.1_Intron|NMNAT3_ENST00000514703.1_Missense_Mutation_p.S3N|NMNAT3_ENST00000512391.1_Missense_Mutation_p.S3N	NM_001200047.1	NP_001186976.1	Q96T66	NMNA3_HUMAN	nicotinamide nucleotide adenylyltransferase 3	3					water-soluble vitamin metabolic process	cytosol|mitochondrion	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)	9						AGGTATTCGGCTCTTCATCTT	0.522000													3	15					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85260961	85260961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:85260961G>A	ENST00000266682.5	-	10	2048	c.1507C>T	c.(1507-1509)Ctt>Ttt	p.L503F	SLC6A15_ENST00000309283.7_Missense_Mutation_p.L211F|SLC6A15_ENST00000552192.1_Missense_Mutation_p.L396F	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	503					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						AATGCCAGAAGACAACAGATA	0.303000													25	63					0	0	1	0	0
S1PR3	1903	broad.mit.edu	37	9	91617111	91617111	+	Silent	SNP	C	C	T	rs138808274		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91617111C>T	ENST00000375846.3	+	1	5691	c.996C>T	c.(994-996)ctC>ctT	p.L332L	S1PR3_ENST00000358157.2_Silent_p.L332L			Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	332					anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(1)	34						AGCCTGCGCTCGACCCAAGCA	0.632000													12	44					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204043	9204043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9204043G>A	ENST00000429566.3	+	1	189	c.123G>A	c.(121-123)ggG>ggA	p.G41G		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TGGTCGTGGGGAACCTGCTCA	0.537000													37	100					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44596418	44596418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44596418C>T	ENST00000372299.3	+	3	1218	c.1160C>T	c.(1159-1161)gCt>gTt	p.A387V		NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	387					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					CCTCCTGCTGCTGGTCCTTAG	0.507000													8	72					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430251	135430251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135430251C>T	ENST00000394143.1	+	6	4677	c.4386C>T	c.(4384-4386)ttC>ttT	p.F1462F	GPR112_ENST00000370652.1_Silent_p.F1462F|GPR112_ENST00000394141.1_Silent_p.F1257F|GPR112_ENST00000412101.1_Silent_p.F1257F|GPR112_ENST00000287534.4_Silent_p.F1399F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1462					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CACAGACTTTCCCTGAGTCCT	0.423000													69	45					0	0	1	0	0
C2orf80	389073	broad.mit.edu	37	2	209045522	209045522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:209045522C>T	ENST00000341287.4	-	6	508	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	C2orf80_ENST00000453017.1_Missense_Mutation_p.E105K|C2orf80_ENST00000451346.1_Missense_Mutation_p.E86K	NM_001099334.2	NP_001092804.1	Q0P641	CB080_HUMAN	chromosome 2 open reading frame 80	105										endometrium(2)|large_intestine(3)|lung(6)|skin(2)	13						TTAAAGACTTCCTCAATCGGG	0.358000													29	84					0	0	1	0	0
DACT3	147906	broad.mit.edu	37	19	47151774	47151774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47151774G>A	ENST00000391916.2	-	4	1928	c.1855C>T	c.(1855-1857)Cgt>Tgt	p.R619C	DACT3_ENST00000300875.4_Missense_Mutation_p.R394C	NM_145056.2	NP_659493.2	Q96B18	DACT3_HUMAN	dishevelled-binding antagonist of beta-catenin 3	619										lung(1)	1		Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000173)|all cancers(93;0.000464)|Epithelial(262;0.02)|GBM - Glioblastoma multiforme(486;0.0325)		GAACCCGAACGGAAACGCAGT	0.577000													138	384					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130797667	130797667	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:130797667G>A	ENST00000509018.1	-	19	2800	c.2595C>T	c.(2593-2595)gcC>gcT	p.A865A	RAPGEF6_ENST00000308008.6_Silent_p.A865A|RAPGEF6_ENST00000507093.1_Silent_p.A865A|RAPGEF6_ENST00000296859.6_Silent_p.A865A|RAPGEF6_ENST00000512052.1_Silent_p.A580A|FNIP1_ENST00000514667.1_Silent_p.A915A|RAPGEF6_ENST00000307984.5_Silent_p.A870A	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	865	Ras-GEF.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		ACAGCTGGGTGGCCACCTCAA	0.403000													30	76					0	0	1	0	0
TMEM207	131920	broad.mit.edu	37	3	190147432	190147432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:190147432G>A	ENST00000354905.2	-	5	459	c.393C>T	c.(391-393)ggC>ggT	p.G131G		NM_207316.1	NP_997199.1	Q6UWW9	TM207_HUMAN	transmembrane protein 207	131						integral to membrane				endometrium(1)|large_intestine(2)|lung(4)	7	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)		AGCCTAAAGGGCCAAAACATG	0.408000													18	88					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169293	90169293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:90169293C>T	ENST00000333209.3	-	2	2487	c.1969G>A	c.(1969-1971)Gga>Aga	p.G657R		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	657										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGAGTGAGTCCTACCTGAGCA	0.577000													17	62					0	0	1	0	0
TCF3	6929	broad.mit.edu	37	19	1615524	1615524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1615524G>A	ENST00000395423.3	-	14	1621	c.1594C>T	c.(1594-1596)Cat>Tat	p.H532Y	TCF3_ENST00000453954.2_Intron|TCF3_ENST00000588136.1_Intron|TCF3_ENST00000262965.5_Intron|TCF3_ENST00000344749.5_Intron			P15923	TFE2_HUMAN	transcription factor 3	533					B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGGGCTATGGGGAGGGCGC	0.721000			T	"""PBX1, HLF, TFPT"""	pre B-ALL								29	64					0	0	1	0	0
FATE1	89885	broad.mit.edu	37	X	150891136	150891136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150891136G>A	ENST00000370350.3	+	5	542	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K		NM_033085.2	NP_149076.1	Q969F0	FATE1_HUMAN	fetal and adult testis expressed 1	153						endoplasmic reticulum|integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(6)|ovary(1)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CGCCCTGGAGGAACAGGGCGC	0.642000													38	23					0	0	1	0	0
GOLGA2P5	55592	broad.mit.edu	37	12	100564756	100564756	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100564756C>T	ENST00000397112.4	-	0	557					NR_036632.1															large_intestine(1)|lung(3)	4						TGGTGGCACTCTTTCTTTTCC	0.522000													32	119					0	0	1	0	0
BPIFB1	92747	broad.mit.edu	37	20	31878790	31878790	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31878790C>T	ENST00000253354.1	+	5	554	c.393C>T	c.(391-393)ttC>ttT	p.F131F		NM_033197.2	NP_149974.2	Q8TDL5	LPLC1_HUMAN	BPI fold containing family B, member 1	131						extracellular space	lipid binding										TCGTGGAGTTCCACATGACGA	0.647000													7	33					0	0	1	0	0
RBM19	9904	broad.mit.edu	37	12	114261086	114261086	+	Silent	SNP	G	G	A	rs140794490		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:114261086G>A	ENST00000545145.2	-	24	2904	c.2826C>T	c.(2824-2826)atC>atT	p.I942I	RBM19_ENST00000392561.3_Silent_p.I942I|RBM19_ENST00000261741.5_Silent_p.I942I	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	942					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GCTGCTCCAGGATCTCGTCCA	0.632000													8	55					0	0	1	0	0
UBE2F	140739	broad.mit.edu	37	2	238944540	238944540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238944540C>T	ENST00000272930.4	+	9	660	c.466C>T	c.(466-468)Cca>Tca	p.P156S	UBE2F_ENST00000409633.1_Intron|UBE2F-SCLY_ENST00000449191.1_Missense_Mutation_p.P102S|UBE2F_ENST00000409953.1_Missense_Mutation_p.P132S|UBE2F_ENST00000409332.1_Missense_Mutation_p.P134S|UBE2F_ENST00000414443.1_Missense_Mutation_p.P124S	NM_001278305.1|NM_080678.2	NP_001265234.1|NP_542409.1	Q969M7	UBE2F_HUMAN	ubiquitin-conjugating enzyme E2F (putative)	156					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding			endometrium(1)|large_intestine(1)	2		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;6.7e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|Kidney(56;3.53e-09)|KIRC - Kidney renal clear cell carcinoma(57;9.79e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000136)|Lung(119;0.0126)|LUSC - Lung squamous cell carcinoma(224;0.0301)		TTTTGATGATCCACTGAATAT	0.373000													15	44					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10788459	10788459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10788459G>A	ENST00000283025.2	-	1	343	c.272C>T	c.(271-273)cCc>cTc	p.P91L		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	91					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						CCAGTCGTGGGGGCTATAGCG	0.672000													16	68					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45795022	45795022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45795022C>T	ENST00000357450.4	-	6	1065	c.1066G>A	c.(1066-1068)Gaa>Aaa	p.E356K	SMC1B_ENST00000404354.3_Missense_Mutation_p.E356K	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	356					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		AAAATTTCTTCCTCAATCTGC	0.378000													23	192					0	0	1	0	0
CERS1	10715	broad.mit.edu	37	19	19004363	19004363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19004363G>A	ENST00000427170.2	-	2	342	c.271C>T	c.(271-273)Ctc>Ttc	p.L91F	CERS1_ENST00000429504.2_Missense_Mutation_p.L91F|CERS1_ENST00000542296.2_5'UTR|GDF1_ENST00000247005.6_5'UTR	NM_001492.4|NM_021267.3	NP_001483.3|NP_067090.1	P27544	CERS1_HUMAN	ceramide synthase 1	91					ceramide biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|microsome	sphingosine N-acyltransferase activity			endometrium(3)|lung(2)	5						CTGGGCTGGAGGCAGCACCGC	0.632000													5	10					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53907760	53907760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:53907760C>T	ENST00000396328.1	-	15	2882	c.2643G>A	c.(2641-2643)caG>caA	p.Q881Q	WDR72_ENST00000360509.5_Silent_p.Q881Q|WDR72_ENST00000559418.1_Silent_p.Q891Q|WDR72_ENST00000557913.1_Silent_p.Q878Q	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	881										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		GAATTCCAACCTGATTTGGAA	0.318000													22	67					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27456001	27456001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27456001C>T	ENST00000264705.4	+	19	3146	c.2984C>T	c.(2983-2985)tCt>tTt	p.S995F	CAD_ENST00000403525.1_Missense_Mutation_p.S932F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	995	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GATGAGATCTCTTTTGAGGTG	0.488000													16	34					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71003108	71003108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71003108C>T	ENST00000334414.6	-	4	764	c.720G>A	c.(718-720)gcG>gcA	p.A240A	PTPRB_ENST00000550358.1_Silent_p.A240A|PTPRB_ENST00000551525.1_Silent_p.A239A|PTPRB_ENST00000261266.5_Silent_p.A22A|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000451516.2_Silent_p.A22A|PTPRB_ENST00000538708.1_Silent_p.A22A|PTPRB_ENST00000550857.1_Silent_p.A22A	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	22	Fibronectin type-III 3.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCTCTGGCTCCGCCAGTCCAG	0.522000													5	56					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16745363	16745363	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:16745363C>T	ENST00000381323.3	-	5	413		c.e5-1		FAM49A_ENST00000406434.1_Splice_Site|FAM49A_ENST00000355549.2_Splice_Site	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A							intracellular		p.?(1)		breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TTTGAATTGCCTGCAAAAACA	0.373000													10	39					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162740180	162740180	+	Missense_Mutation	SNP	C	C	T	rs140710321	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:162740180C>T	ENST00000367922.2	+	13	1820	c.1382C>T	c.(1381-1383)tCa>tTa	p.S461L	DDR2_ENST00000367921.3_Missense_Mutation_p.S461L	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	461					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CGCTCCTCATCACCTAGTGAA	0.498000													55	117					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234891	21234891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21234891C>T	ENST00000233242.1	-	26	4976	c.4849G>A	c.(4849-4851)Gga>Aga	p.G1617R		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1617					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTAGTGATCCAGAAAGCAGG	0.423000													20	49					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324106	79324106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79324106C>T	ENST00000428286.1	-	8	3207	c.2007G>A	c.(2005-2007)ggG>ggA	p.G669G	PRUNE2_ENST00000376718.3_Silent_p.G1028G			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1028					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TGTCTAGGTTCCCAGGACCTG	0.448000													12	21					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74401596	74401596	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74401596G>A	ENST00000319380.7	-	2	540	c.477_splice	c.e2+1	p.T159_splice		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	159							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						AGGACTCACGGTGGATCGCAT	0.602000													4	10					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30915444	30915444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30915444C>T	ENST00000375712.3	+	7	2115	c.1948C>T	c.(1948-1950)Cgt>Tgt	p.R650C	KIF3B_ENST00000418717.2_Missense_Mutation_p.R276C	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	650	Globular.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CATGATGATTCGTCCAGAGGC	0.478000													21	76					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21840062	21840062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21840062G>A	ENST00000216297.2	-	3	639	c.301C>T	c.(301-303)Cct>Tct	p.P101S		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	101					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		GTGATGGCAGGGGCTCCATTA	0.383000													16	60					0	0	1	0	0
CHKB	1120	broad.mit.edu	37	22	51018247	51018247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:51018247G>A	ENST00000406938.2	-	9	1157	c.940C>T	c.(940-942)Cgt>Tgt	p.R314C	CHKB-CPT1B_ENST00000452668.1_5'UTR	NM_005198.4	NP_005189.2	Q9Y259	CHKB_HUMAN	choline kinase beta	314					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|ovary(3)|skin(1)|urinary_tract(1)	15		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	AGGTAATGACGAATAAAATGC	0.488000													58	119					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44800029	44800029	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44800029C>T	ENST00000309315.4	+	9	1200	c.1077C>T	c.(1075-1077)acC>acT	p.T359T	ZMIZ2_ENST00000441627.1_Silent_p.T359T|ZMIZ2_ENST00000433667.1_Silent_p.T327T|ZMIZ2_ENST00000413916.1_Silent_p.T301T|ZMIZ2_ENST00000265346.7_Silent_p.T333T	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	359	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TACAGCCTACCCGTTCCATCC	0.587000													7	73					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12837370	12837370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12837370C>T	ENST00000357726.4	+	3	1107	c.1080C>T	c.(1078-1080)atC>atT	p.I360I		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	360										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTGTGGGATCGTGGATTCCC	0.617000													50	138					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6926366	6926366	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6926366G>A	ENST00000011653.4	+	7	1284	c.1026G>A	c.(1024-1026)ttG>ttA	p.L342L		NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	342	Ig-like C2-type 3.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				TGCTGAGTTTGAAACTGGAGA	0.567000													7	21					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128491627	128491627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128491627C>T	ENST00000325888.8	+	35	6048	c.5787C>T	c.(5785-5787)atC>atT	p.I1929I	FLNC_ENST00000346177.6_Silent_p.I1896I|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1929					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ACAGCATCATCGTGCGCTTCG	0.587000													30	76					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56490890	56490890	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56490890G>A	ENST00000291971.3	+	9	3078	c.3007G>A	c.(3007-3009)Gag>Aag	p.E1003K	NLRP8_ENST00000590542.1_Missense_Mutation_p.E984K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	1003						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GACCTTGTGCGAGGCCTTCTC	0.478000													42	106					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420762	55420762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55420762C>T	ENST00000242994.3	+	2	917	c.539C>T	c.(538-540)tCt>tTt	p.S180F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	180					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						GGCCCTCAGTCTGTCCTCCTG	0.537000													26	68					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41160355	41160355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41160355G>A	ENST00000263413.3	-	11	1837	c.1573C>T	c.(1573-1575)Cca>Tca	p.P525S	C6_ENST00000337836.5_Missense_Mutation_p.P525S|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	525	EGF-like.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTAGGGCATGGAGCACACTGG	0.507000													45	126					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11596488	11596488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11596488C>T	ENST00000304391.6	+	5	701	c.583C>T	c.(583-585)Ctt>Ttt	p.L195F	PTCHD2_ENST00000389575.3_Silent_p.F1308F|PTCHD2_ENST00000294484.6_Silent_p.F1308F			Q9P2K9	PTHD2_HUMAN	patched domain containing 2	0					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TGCCCCTCTTCTTCTGCATCA	0.642000													23	65					0	0	1	0	0
ZMYND10	51364	broad.mit.edu	37	3	50380626	50380626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50380626C>T	ENST00000231749.3	-	6	1794	c.522G>A	c.(520-522)aaG>aaA	p.K174K	ZMYND10_ENST00000360165.3_Silent_p.K174K|ZMYND10-AS1_ENST00000440013.1_RNA	NM_015896.2	NP_056980.2	O75800	ZMY10_HUMAN	zinc finger, MYND-type containing 10	174						cytoplasm	protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|urinary_tract(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCTCTGCCTGCTTCTGCAGCT	0.577000										TSP Lung(30;0.18)			19	39					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049851	69049851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69049851C>T	ENST00000295381.3	+	10	1996	c.1577C>T	c.(1576-1578)tCc>tTc	p.S526F	ARHGAP25_ENST00000479844.1_Missense_Mutation_p.S220F|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.S487F|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.S520F|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.S519F|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.S527F	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	526					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						GCCTGTGACTCCAAGGGAGAT	0.527000													61	110					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84683354	84683354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84683354C>T	ENST00000286744.5	+	24	4258	c.4034C>T	c.(4033-4035)tCc>tTc	p.S1345F	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.S1345F	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1345	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGCAATGTTTCCTTGCTTTTC	0.428000													53	176					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7618780	7618780	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7618780C>T	ENST00000221249.6	+	22	2597	c.2166C>T	c.(2164-2166)ccC>ccT	p.P722P	PNPLA6_ENST00000600737.1_Silent_p.P760P|PNPLA6_ENST00000545201.2_Silent_p.P695P|PNPLA6_ENST00000450331.3_Silent_p.P722P|PNPLA6_ENST00000414982.3_Silent_p.P770P	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	761					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						TGGGTGTGCCCCCACACTCGG	0.582000													14	54					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23897778	23897778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23897778C>T	ENST00000355349.3	-	15	1671	c.1509G>A	c.(1507-1509)aaG>aaA	p.K503K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	503	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CGATGCCCTCCTTCTTGTACT	0.512000													33	112					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77377921	77377921	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77377921C>T	ENST00000451710.3	-	26	3903	c.3666G>A	c.(3664-3666)ctG>ctA	p.L1222L	TRPM6_ENST00000376864.4_Silent_p.L1222L|TRPM6_ENST00000361255.3_Silent_p.L1217L|TRPM6_ENST00000360774.1_Silent_p.L1222L|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Silent_p.L1217L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1222					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AAAGGACTTTCAGGGTATCCA	0.473000													24	80					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48438674	48438674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48438674C>T	ENST00000224605.2	-	1	302	c.37G>A	c.(37-39)Ggg>Agg	p.G13R		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	13					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						agcTGGGGCCCGGGTCCCGGG	0.726000													5	25					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30963132	30963132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30963132C>T	ENST00000311813.4	+	4	753	c.698C>T	c.(697-699)cCa>cTa	p.P233L	AQP1_ENST00000434909.2_Missense_Mutation_p.P293L|AQP1_ENST00000441328.2_Missense_Mutation_p.P150L|AQP1_ENST00000409899.1_Missense_Mutation_p.P118L|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Missense_Mutation_p.P182L|AQP1_ENST00000509504.1_Missense_Mutation_p.P410L	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				ATCCTGGCCCCACGCAGCAGT	0.597000													19	28					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5227059	5227059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5227059C>T	ENST00000334314.3	-	1	85	c.9G>A	c.(7-9)acG>acA	p.T3T	AKR1CL1_ENST00000445191.1_Intron					aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						GCTTCAGATCCGTCATCATCC	0.507000													20	43					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66478830	66478830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:66478830C>T	ENST00000256447.4	-	3	1998	c.1841G>A	c.(1840-1842)aGg>aAg	p.R614K		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	614	LRRCT.				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		CTTAACTCCCCTTAGAGATGG	0.413000													37	79					0	0	1	0	0
MOXD1	26002	broad.mit.edu	37	6	132693826	132693826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:132693826G>A	ENST00000367963.3	-	4	702	c.584C>T	c.(583-585)cCc>cTc	p.P195L	MOXD1_ENST00000336749.3_Missense_Mutation_p.P127L	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	195					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		GTTTGGGATGGGGACCTGTCT	0.373000													30	40					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28478849	28478849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28478849G>A	ENST00000261609.7	-	28	4420	c.4312C>T	c.(4312-4314)Cgc>Tgc	p.R1438C		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1438					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AACAACAAGCGACCGACCTCT	0.463000													29	67					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541199	55541199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55541199C>T	ENST00000220676.1	+	4	4905	c.4757C>T	c.(4756-4758)cCa>cTa	p.P1586L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1586					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATCAAAAGTCCAGTGACTTCT	0.403000													42	55					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121353122	121353122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121353122G>A	ENST00000314583.3	-	10	926	c.835C>T	c.(835-837)Cca>Tca	p.P279S	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.P242S	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	279					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		ACTGGCTGTGGAGCCTCAGGG	0.597000													23	64					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52595973	52595973	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52595973C>T	ENST00000395489.2	-	8	840	c.444G>A	c.(442-444)gaG>gaA	p.E148E	A1CF_ENST00000395495.1_Silent_p.E155E|A1CF_ENST00000373993.1_Silent_p.E155E|A1CF_ENST00000374001.1_Silent_p.E155E|A1CF_ENST00000373995.3_Silent_p.E163E|A1CF_ENST00000373997.3_Silent_p.E155E|A1CF_ENST00000282641.2_Silent_p.E155E	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	155	RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CCTTTTTCATCTCCGATAAGA	0.468000													29	131					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62675455	62675455	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62675455G>A	ENST00000498273.1	+	4	1304	c.1008_splice	c.e4-1	p.D337_splice		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	337										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						TAACTTTCAGGATAAAACCCT	0.294000													19	79					0	0	1	0	0
IGHA1	3493	broad.mit.edu	37	14	106173691	106173691	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106173691G>A	ENST00000390547.2	-	0	875																											TGGTCACAGCGAAGGTGGTGG	0.662000													17	81					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140985474	140985474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140985474C>T	ENST00000544766.1	+	5	1563	c.1036C>T	c.(1036-1038)Ccc>Tcc	p.P346S	MAGEC3_ENST00000298296.1_Silent_p.I596I|MAGEC3_ENST00000536088.1_Missense_Mutation_p.P346S|MAGEC3_ENST00000409007.1_Missense_Mutation_p.P346S|MAGEC3_ENST00000443323.2_Missense_Mutation_p.P266S	NM_177456.2	NP_803251.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	0	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGTATCATCCCTAGTGCCT	0.473000													64	41					0	0	1	0	0
MRPL4	51073	broad.mit.edu	37	19	10368915	10368915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10368915C>T	ENST00000393733.2	+	6	490	c.463C>T	c.(463-465)Ccc>Tcc	p.P155S	MRPL4_ENST00000588502.1_Missense_Mutation_p.P154S|CTD-2369P2.5_ENST00000592893.1_RNA|MRPL4_ENST00000590669.1_Missense_Mutation_p.P155S|MRPL4_ENST00000307422.5_Missense_Mutation_p.P155S|MRPL4_ENST00000253099.6_Missense_Mutation_p.P155S			Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4	155					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		TGCCCATGGCCCCCGGGGCCC	0.637000													5	39					0	0	1	0	0
CLEC2B	9976	broad.mit.edu	37	12	10010183	10010183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10010183G>A	ENST00000228438.2	-	3	1060	c.127C>T	c.(127-129)Caa>Taa	p.Q43*		NM_005127.2	NP_005118.2	Q92478	CLC2B_HUMAN	C-type lectin domain family 2, member B	43	C-type lectin.					integral to plasma membrane	sugar binding			endometrium(1)|large_intestine(3)|lung(1)	5						CATTTGTTTTGGAAACCAATC	0.318000													9	34					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370219	126370219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126370219C>T	ENST00000394329.3	+	9	8061	c.8048C>T	c.(8047-8049)tCc>tTc	p.S2683F	FAT4_ENST00000335110.5_Missense_Mutation_p.S981F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2683	Cadherin 26.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAAAACCTTTCCCCTCGAAAA	0.353000													73	174					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416045	178416045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178416045G>A	ENST00000231188.5	-	6	1423	c.1245C>T	c.(1243-1245)ctC>ctT	p.L415L	GRM6_ENST00000517717.1_Silent_p.L415L|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	415					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GCATGCTGTGGAGGGCGTGGG	0.632000													12	22					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141607771	141607771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141607771G>A	ENST00000389484.3	-	29	5810	c.4839C>T	c.(4837-4839)ttC>ttT	p.F1613F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1613					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGATGCATCGAAGTCTATCA	0.373000										TSP Lung(27;0.18)			31	79					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9027420	9027420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9027420C>T	ENST00000383836.3	-	22	3510	c.3083G>A	c.(3082-3084)aGc>aAc	p.S1028N	SRGAP3_ENST00000360413.3_Missense_Mutation_p.S1004N	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	1028					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GGAGCTGCTGCTGCGGCGCAT	0.726000			T	RAF1	pilocytic astrocytoma								28	41					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20668326	20668326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20668326G>A	ENST00000404938.2	+	4	776	c.124G>A	c.(124-126)Gga>Aga	p.G42R		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	695	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						CTTTGCTGATGGACTGGACAT	0.463000													7	36					0	0	1	0	0
FAM214B	80256	broad.mit.edu	37	9	35108046	35108046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35108046G>A	ENST00000378561.1	-	2	3281	c.226C>T	c.(226-228)Ccc>Tcc	p.P76S	FAM214B_ENST00000322813.5_Missense_Mutation_p.P76S|FAM214B_ENST00000488109.2_Missense_Mutation_p.P76S|FAM214B_ENST00000378554.2_Missense_Mutation_p.P76S|FAM214B_ENST00000603301.1_Missense_Mutation_p.P76S|FAM214B_ENST00000378557.1_Missense_Mutation_p.P76S|FAM214B_ENST00000378566.1_Intron|FAM214B_ENST00000605244.1_Missense_Mutation_p.P76S			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	76						nucleus											AGCTCCCGGGGACCCTCAGTG	0.637000													11	32					0	0	1	0	0
TMEM74	157753	broad.mit.edu	37	8	109797140	109797140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:109797140G>A	ENST00000297459.3	-	2	366	c.188C>T	c.(187-189)tCt>tTt	p.S63F	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	63					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			GGATGCTGGAGAAGAACTAAG	0.517000													12	131					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121328208	121328208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121328208C>T	ENST00000297848.3	+	40	4901	c.4631C>T	c.(4630-4632)cCa>cTa	p.P1544L	COL14A1_ENST00000309791.4_Missense_Mutation_p.P1544L|COL14A1_ENST00000247781.3_Missense_Mutation_p.P1449L	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1544	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GTTGGTTCACCAGGACGTGAT	0.502000													14	37					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71490409	71490409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71490409C>T	ENST00000296755.7	+	5	1525	c.1227C>T	c.(1225-1227)gtC>gtT	p.V409V		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	409						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTGATCCTGTCATTCTTTTCC	0.403000													26	104					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724491	138724491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138724491G>A	ENST00000383163.2	-	1	619	c.620C>T	c.(619-621)tCa>tTa	p.S207L		NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	207	Pro-rich.									endometrium(3)|kidney(1)|lung(7)	11						GTGTCCCTCTGAACTGGGGTT	0.652000													5	14					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75276414	75276414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75276414C>T	ENST00000325680.7	+	7	4977	c.4853C>T	c.(4852-4854)cCc>cTc	p.P1618L	YLPM1_ENST00000238571.3_Missense_Mutation_p.P1423L|YLPM1_ENST00000552421.1_Missense_Mutation_p.P912L	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		TCTTCCATTCCCCCTCCTGGC	0.483000													11	55					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147108974	147108974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:147108974C>T	ENST00000383075.3	-	4	1260	c.748G>A	c.(748-750)Gac>Aac	p.D250N	ZIC4_ENST00000525172.2_Missense_Mutation_p.D300N|ZIC4_ENST00000425731.3_Missense_Mutation_p.D288N|ZIC4_ENST00000491672.1_Missense_Mutation_p.D44N|ZIC4_ENST00000472749.2_5'UTR|ZIC4_ENST00000473123.1_Missense_Mutation_p.D250N|ZIC4_ENST00000484399.1_Missense_Mutation_p.D250N	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	250						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TTCTTACGGTCGCTGCTGTTG	0.612000													8	32					0	0	1	0	0
DHRS2	10202	broad.mit.edu	37	14	24108541	24108541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24108541G>A	ENST00000250383.6	+	3	770	c.294G>A	c.(292-294)gaG>gaA	p.E98E	DHRS2_ENST00000553896.1_3'UTR|DHRS2_ENST00000344777.7_Silent_p.E98E	NM_005794.3	NP_005785.1	Q13268	DHRS2_HUMAN	dehydrogenase/reductase (SDR family) member 2	76					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00659)		GGAAGGCTGAGGACCGGGAGC	0.652000													11	37					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815131	106815131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106815131G>A	ENST00000407775.2	+	8	3071	c.2821G>A	c.(2821-2823)Ggc>Agc	p.G941S	ZFPM2_ENST00000520492.1_Missense_Mutation_p.G809S|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.G672S|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.G809S|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	941					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AACCCTGCAAGGCTTGAAGGT	0.408000													10	28					0	0	1	0	0
AHCY	191	broad.mit.edu	37	20	32879235	32879235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32879235G>A	ENST00000538132.1	-	5	850	c.464C>T	c.(463-465)tCc>tTc	p.S155F	AHCY_ENST00000217426.2_Missense_Mutation_p.S183F	NM_001161766.1	NP_001155238.1	P23526	SAHH_HUMAN	adenosylhomocysteinase	183					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding			endometrium(6)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CTTGGTGACGGAGTCATTGAC	0.572000													44	96					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116067573	116067573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116067573C>T	ENST00000369271.3	-	10	1363	c.1063G>A	c.(1063-1065)Gag>Aag	p.E355K	AFAP1L2_ENST00000304129.4_Missense_Mutation_p.E355K|AFAP1L2_ENST00000545353.1_Missense_Mutation_p.E408K	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	355	PH 2.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		CTGGATGTCTCGAGGGACCTC	0.542000													15	54					0	0	1	0	0
MIOX	55586	broad.mit.edu	37	22	50927994	50927994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50927994C>T	ENST00000395732.3	+	9	692	c.670C>T	c.(670-672)Ccc>Tcc	p.P224S	MIOX_ENST00000395733.3_Intron|MIOX_ENST00000216075.6_Missense_Mutation_p.P224S			Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	224					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	13		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTCCTTCTACCCCTGGCACAC	0.677000													16	29					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961754	34961754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34961754C>T	ENST00000329357.5	+	1	842	c.806C>T	c.(805-807)tCc>tTc	p.S269F		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	269	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						ACTCTGGTGTCCAGTGTCCAC	0.627000													47	38					0	0	1	0	0
KLRC1	3821	broad.mit.edu	37	12	10603085	10603085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10603085G>A	ENST00000544822.1	-	4	668	c.281C>T	c.(280-282)cCc>cTc	p.P94L	KLRC1_ENST00000408006.3_Missense_Mutation_p.P94L|KLRC1_ENST00000347831.5_Missense_Mutation_p.P94L|KLRC1_ENST00000359151.3_Missense_Mutation_p.P94L|KLRC1_ENST00000536188.1_Missense_Mutation_p.P94L	NM_213658.2	NP_998823.1	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C, member 1	94					cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16						AGACTTACAGGGAATAACAAC	0.383000													25	100					0	0	1	0	0
PDCD7	10081	broad.mit.edu	37	15	65411101	65411101	+	Missense_Mutation	SNP	G	G	A	rs61756022	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65411101G>A	ENST00000204549.4	-	5	1466	c.1412C>T	c.(1411-1413)cCg>cTg	p.P471L		NM_005707.1	NP_005698.1	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	471					apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex				endometrium(4)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	7						GCTGGGGAGCGGGGGAAGGAC	0.498000													23	81					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1943501	1943501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1943501C>T	ENST00000543818.1	+	5	1569	c.727C>T	c.(727-729)Ccc>Tcc	p.P243S	CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000588077.1_Intron|LRTM2_ENST00000543730.1_3'UTR|LRTM2_ENST00000299194.1_Missense_Mutation_p.P243S|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000382722.5_Intron|LRTM2_ENST00000535041.1_Missense_Mutation_p.P243S	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	243	LRRCT.					integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GCGGATGGTCCCCATGGAGAT	0.602000													13	44					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14711407	14711407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14711407C>T	ENST00000284268.6	-	12	1708	c.1378G>A	c.(1378-1380)Gag>Aag	p.E460K	ANKH_ENST00000535119.1_Missense_Mutation_p.E262K	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	460					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						GACTCATTCTCCATCTTCTTT	0.532000													10	163					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11535948	11535948	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11535948T>A	ENST00000262442.3	+	8	1631	c.1563T>A	c.(1561-1563)gaT>gaA	p.D521E	DNAH9_ENST00000454412.2_Missense_Mutation_p.D521E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	521	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AAGTAGAAGATCTTGACCGAA	0.408000													36	76					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121786416	121786416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121786416G>A	ENST00000261367.7	+	12	3443	c.2015G>A	c.(2014-2016)gGa>gAa	p.G672E	SNCAIP_ENST00000261368.8_Missense_Mutation_p.G625E|SNCAIP_ENST00000414317.2_Missense_Mutation_p.G227E|SNCAIP_ENST00000542191.1_Missense_Mutation_p.G183E|SNCAIP_ENST00000379538.3_Missense_Mutation_p.G259E|CTC-210G5.1_ENST00000505546.1_RNA|CTC-210G5.1_ENST00000510972.1_RNA|CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000379536.2_Missense_Mutation_p.G565E|SNCAIP_ENST00000503116.2_3'UTR|SNCAIP_ENST00000504884.2_3'UTR|CTC-210G5.1_ENST00000503529.1_RNA|CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000379533.2_Missense_Mutation_p.G672E			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	625					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CAGTTATTGGGAAAGGAAATC	0.458000													23	59					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37251039	37251039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37251039C>T	ENST00000310758.4	-	13	1685	c.1038G>A	c.(1036-1038)gaG>gaA	p.E346E	ELMO1_ENST00000448602.1_Silent_p.E346E|ELMO1_ENST00000442504.1_Silent_p.E346E	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	346	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						ACTTGCGTTTCTCCATGCTGC	0.488000													21	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179505290	179505290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179505290C>T	ENST00000589042.1	-	221	40925	c.40701G>A	c.(40699-40701)agG>agA	p.R13567R	TTN_ENST00000342992.6_Silent_p.R10999R|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.R11926R|TTN_ENST00000342175.6_Silent_p.R4694R|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000418062.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.R4627R|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.R4502R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11926	Ig-like 92.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGGAATCTTCCTTTCCCTTT	0.323000													26	126					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4327185	4327185	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4327185G>A	ENST00000600324.1	-	8	766	c.699C>T	c.(697-699)ttC>ttT	p.F233F	STAP2_ENST00000597593.1_5'UTR|STAP2_ENST00000594605.1_Silent_p.F233F	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	233	SH2.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TATGCGACACGAAATAGTTGA	0.617000													8	56					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799175	45799175	+	Silent	SNP	G	G	A	rs146049499		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45799175G>A	ENST00000553795.1	-	4	1004	c.696C>T	c.(694-696)acC>acT	p.T232T	OR13A1_ENST00000536058.1_Silent_p.T232T|OR13A1_ENST00000374401.2_Silent_p.T232T	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						AGGACGCGATGGTCATCAGGA	0.572000													26	82					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69329484	69329484	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:69329484C>T	ENST00000260364.5	+	9	1552	c.1251C>T	c.(1249-1251)gcC>gcT	p.A417A	NOX5_ENST00000448182.3_Silent_p.A389A|NOX5_ENST00000530406.2_Silent_p.A407A|NOX5_ENST00000455873.3_Silent_p.A400A|NOX5_ENST00000388866.3_Silent_p.A435A			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	435	Ferric oxidoreductase.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						TGGAGAAGGCCATCGGACTGG	0.567000													35	97					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4348328	4348328	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4348328C>T	ENST00000355530.2	+	3	547	c.265_splice	c.e3-1	p.V89_splice	SPNS3_ENST00000576069.1_Intron|SPNS3_ENST00000333476.2_Intron	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	89					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						CTCCTTCAGTCTTCGTTAGCT	0.612000													67	160					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128365332	128365332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128365332G>A	ENST00000262462.4	+	9	2625	c.1615G>A	c.(1615-1617)Gaa>Aaa	p.E539K	SLC27A6_ENST00000506176.1_Missense_Mutation_p.E539K|SLC27A6_ENST00000395266.1_Missense_Mutation_p.E539K			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	539					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TTTAGATTTGGAAAAAGTTTA	0.303000													22	43					0	0	1	0	0
RANBP10	57610	broad.mit.edu	37	16	67763634	67763634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67763634G>A	ENST00000317506.3	-	9	1211	c.1096C>T	c.(1096-1098)Ccc>Tcc	p.P366S	RANBP10_ENST00000411657.2_Missense_Mutation_p.P249S|RANBP10_ENST00000602677.1_Missense_Mutation_p.P366S|RANBP10_ENST00000536251.1_Missense_Mutation_p.P137S|RANBP10_ENST00000448631.2_Missense_Mutation_p.P310S	NM_020850.1	NP_065901.1	Q6VN20	RBP10_HUMAN	RAN binding protein 10	366	Ser-rich.									endometrium(5)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		CTGAGGCTGGGGGAGCCAGGG	0.607000													22	71					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143412128	143412128	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:143412128C>T	ENST00000316549.6	-	5	763	c.555G>A	c.(553-555)gtG>gtA	p.V185V		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	185					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						TCATAGCCTTCACAAAACCAT	0.378000													28	81					0	0	1	0	0
ADRBK2	157	broad.mit.edu	37	22	26118352	26118352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26118352C>T	ENST00000324198.5	+	21	2194	c.2002C>T	c.(2002-2004)Cct>Tct	p.P668S		NM_005160.3	NP_005151.2	P35626	ARBK2_HUMAN	adrenergic, beta, receptor kinase 2	668							ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|skin(3)|stomach(2)	32					Adenosine triphosphate(DB00171)	CCTCAACAAACCTCGGTCAGG	0.552000													29	70					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884549	228884549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228884549G>A	ENST00000392056.3	-	7	1067	c.1021C>T	c.(1021-1023)Cca>Tca	p.P341S	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P341S	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	341						cytoplasm	protein binding	p.P341T(2)|p.P341K(2)		NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCATCTTTTGGAATATACAGT	0.423000													58	130					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88780987	88780987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88780987C>T	ENST00000418177.2	-	2	421	c.54G>A	c.(52-54)ggG>ggA	p.G18G	GRM5_ENST00000455756.2_Silent_p.G18G|GRM5_ENST00000305447.4_Silent_p.G18G|GRM5_ENST00000393297.1_Silent_p.G18G|GRM5_ENST00000305432.5_Silent_p.G18G|GRM5_ENST00000393294.3_Silent_p.G18G			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	18					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ACTGTGCACTCCCACGGACAT	0.468000													31	70					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368848	86368848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:86368848C>T	ENST00000400286.2	-	2	2394	c.1796G>A	c.(1795-1797)cGa>cAa	p.R599Q		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	599						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CGTAAGAGATCGTAAAATAGT	0.418000													38	119					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8752443	8752443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8752443G>A	ENST00000534127.1	-	6	779	c.394C>T	c.(394-396)Ctc>Ttc	p.L132F	ST5_ENST00000313726.6_Missense_Mutation_p.L132F|ST5_ENST00000530438.1_Intron|ST5_ENST00000357665.1_Missense_Mutation_p.L132F|ST5_ENST00000526757.1_Intron	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	132					positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		GCAAGGGGGAGGCAGGCAGCG	0.667000													16	75					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152737732	152737732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152737732G>A	ENST00000367255.5	-	41	6441	c.5840C>T	c.(5839-5841)tCc>tTc	p.S1947F	SYNE1_ENST00000448038.1_Missense_Mutation_p.S1954F|SYNE1_ENST00000423061.1_Missense_Mutation_p.S1954F|SYNE1_ENST00000265368.4_Missense_Mutation_p.S1947F|SYNE1_ENST00000341594.5_Missense_Mutation_p.S1984F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1947					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGCTCTGCAGGAAGTCCTTTG	0.502000										HNSCC(10;0.0054)			37	67					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80045076	80045076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80045076G>A	ENST00000306749.2	-	21	3495	c.3277C>T	c.(3277-3279)Cac>Tac	p.H1093Y		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1093					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CCGGAGATGTGGACGCCTCCG	0.667000													4	17					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9084665	9084665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9084665C>T	ENST00000397910.4	-	1	7353	c.7150G>A	c.(7150-7152)Gat>Aat	p.D2384N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2384	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTAGTGACATCCATAGTTGAA	0.473000													16	27					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110399131	110399131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110399131G>A	ENST00000360185.4	-	11	1103	c.939C>T	c.(937-939)gtC>gtT	p.V313V	GIT2_ENST00000338373.5_Silent_p.V313V|GIT2_ENST00000343646.5_Silent_p.V313V|GIT2_ENST00000547815.1_Silent_p.V313V|GIT2_ENST00000553118.1_Silent_p.V313V|GIT2_ENST00000551209.1_Silent_p.V312V|GIT2_ENST00000361006.5_Silent_p.V313V|TCHP_ENST00000550780.1_Intron|GIT2_ENST00000356259.4_Silent_p.V313V|GIT2_ENST00000355312.3_Silent_p.V313V|GIT2_ENST00000354574.4_Silent_p.V315V|GIT2_ENST00000320063.9_Silent_p.V313V|GIT2_ENST00000457474.2_Silent_p.V315V			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	313					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						GAAAGGGGACGACCGTTGTCT	0.517000													23	43					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588254	93588254	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93588254G>A	ENST00000329082.7	-	4	1598	c.1327C>T	c.(1327-1329)Ctg>Ttg	p.L443L	RGMA_ENST00000543599.1_Silent_p.L427L|RGMA_ENST00000538818.1_Silent_p.L334L|RGMA_ENST00000557420.1_3'UTR|RGMA_ENST00000425933.2_Silent_p.L427L|RGMA_ENST00000557301.1_Silent_p.L451L|RGMA_ENST00000556658.1_Silent_p.L334L|RGMA_ENST00000542321.2_Silent_p.L427L	NM_020211.2	NP_064596.2	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	443					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			AGCAGGGCCAGGAGCGGGACG	0.716000													13	14					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774191	40774191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:40774191G>A	ENST00000602553.1	-	5	1378	c.1084C>T	c.(1084-1086)Ctc>Ttc	p.L362F	ZNF658_ENST00000377626.3_Missense_Mutation_p.L362F|ZNF658_ENST00000441795.1_Missense_Mutation_p.L360F			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTCTGGTAGAGGGCATCTGTA	0.363000													89	195					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134991144	134991144	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:134991144C>T	ENST00000535938.1	+	13	1730	c.1563C>T	c.(1561-1563)tcC>tcT	p.S521S	SAGE1_ENST00000537770.1_Intron|SAGE1_ENST00000370709.3_Silent_p.S521S|SAGE1_ENST00000324447.3_Silent_p.S521S	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	521										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					GTATTCCATCCATGAGTACCA	0.403000													39	23					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76412312	76412312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76412312G>A	ENST00000357063.3	+	21	4847	c.3587G>A	c.(3586-3588)cGa>cAa	p.R1196Q	LMO7_ENST00000377534.3_Missense_Mutation_p.R1196Q|LMO7_ENST00000321797.8_Missense_Mutation_p.R911Q|LMO7_ENST00000526202.1_Missense_Mutation_p.R788Q|LMO7_ENST00000341547.4_Missense_Mutation_p.R862Q|LMO7_ENST00000465261.2_Missense_Mutation_p.R911Q			Q8WWI1	LMO7_HUMAN	LIM domain 7	1196						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TTAAAAAGGCGATCACAATTT	0.338000													9	40					0	0	1	0	0
WNT10B	7480	broad.mit.edu	37	12	49359997	49359997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49359997G>A	ENST00000301061.4	-	5	1399	c.1051C>T	c.(1051-1053)Cgt>Tgt	p.R351C	WNT10B_ENST00000403957.1_3'UTR|WNT10B_ENST00000407467.1_3'UTR	NM_003394.3	NP_003385.2	O00744	WN10B_HUMAN	wingless-type MMTV integration site family, member 10B	351					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|large_intestine(5)|lung(12)|prostate(1)|skin(4)	23						TTGTGCCCACGGCCACAGCAC	0.627000													5	59					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108819293	108819293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108819293G>A	ENST00000232603.5	-	5	367	c.285C>T	c.(283-285)ttC>ttT	p.F95F	MORC1_ENST00000483760.1_Silent_p.F95F	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	95					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						ATTGCCCTATGAACTTCAAGG	0.363000													54	134					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52822170	52822170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52822170C>T	ENST00000252245.5	-	7	1472	c.1252G>A	c.(1252-1254)Gag>Aag	p.E418K	RP11-1020M18.10_ENST00000548135.1_RNA	NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	418	Coil 2.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		TGCAGGGCCTCCTCAAGGTCC	0.597000													8	41					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324972	152324972	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152324972G>A	ENST00000388718.5	-	3	5362	c.5290C>T	c.(5290-5292)Cat>Tat	p.H1764Y	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1764							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTCTCATGAACTATGGAT	0.507000													93	254					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237037099	237037099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237037099C>T	ENST00000366577.5	+	23	2826	c.2432C>T	c.(2431-2433)cCa>cTa	p.P811L	MTR_ENST00000535889.1_Missense_Mutation_p.P760L	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	811	B12-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GTCATGACTCCATGTGATAAG	0.378000													27	84					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52472065	52472065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52472065G>A	ENST00000231721.2	-	14	1659	c.1660C>T	c.(1660-1662)Ctt>Ttt	p.L554F		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	554					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CGCTTGCCAAGGCTGGGGCGG	0.672000													9	32					0	0	1	0	0
RIOK3	8780	broad.mit.edu	37	18	21053552	21053552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21053552C>T	ENST00000339486.3	+	8	1592	c.975C>T	c.(973-975)atC>atT	p.I325I	RIOK3_ENST00000581585.1_Silent_p.I309I|RIOK3_ENST00000577501.1_Silent_p.I325I	NM_003831.3	NP_003822.2	O14730	RIOK3_HUMAN	RIO kinase 3	325	Protein kinase.			I -> H (in Ref. 1; AAC26080).	chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(2)	10	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GTAAGATCATCCGCATGTGGG	0.323000													7	50					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11000810	11000810	+	Silent	SNP	C	C	T	rs141202424	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11000810C>T	ENST00000324288.8	+	11	1594	c.1461C>T	c.(1459-1461)atC>atT	p.I487I	CIITA_ENST00000381835.5_Intron|CIITA_ENST00000537380.1_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	487	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						TCAGCCACATCTTGAAGAGAC	0.622000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								51	110					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37334448	37334448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37334448C>T	ENST00000262825.5	+	14	2833	c.2616C>T	c.(2614-2616)ccC>ccT	p.P872P	CSF2RB_ENST00000406230.1_Silent_p.P872P|CSF2RB_ENST00000403662.3_Silent_p.P866P|CSF2RB_ENST00000536485.1_Silent_p.P813P	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	866					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	AGGCTGTGCCCCAGGTGCCCG	0.592000													40	163					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	72431580	72431580	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:72431580C>T	ENST00000553530.1	+	2	279	c.72C>T	c.(70-72)atC>atT	p.I24I	RGS6_ENST00000556437.1_Silent_p.I24I|RGS6_ENST00000343854.6_Silent_p.I24I|RGS6_ENST00000402788.2_Silent_p.I24I|RGS6_ENST00000555571.1_Silent_p.I24I|RGS6_ENST00000406236.4_Silent_p.I24I|RGS6_ENST00000404301.2_Silent_p.I24I|RGS6_ENST00000553525.1_Silent_p.I24I|RGS6_ENST00000355512.6_Silent_p.I24I|RGS6_ENST00000407322.4_Silent_p.I24I	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	24					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAAACATGATCGTTTACTGCA	0.502000													23	64					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117663617	117663617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117663617G>A	ENST00000368508.3	-	28	4813	c.4615C>T	c.(4615-4617)Cct>Tct	p.P1539S	ROS1_ENST00000368507.3_Missense_Mutation_p.P1533S|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1539	Fibronectin type-III 6.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGTTCCAAAGGATCTGAATAA	0.333000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								6	49					0	0	1	0	0
SMTN	6525	broad.mit.edu	37	22	31489689	31489689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31489689C>T	ENST00000404574.1	+	1	346	c.256C>T	c.(256-258)Cca>Tca	p.P86S	SMTN_ENST00000333137.7_Intron|SMTN_ENST00000347557.2_Intron|SMTN_ENST00000358743.1_Intron			P53814	SMTN_HUMAN	smoothelin	209					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						GCTGGGGGTCCCACTTGTGTC	0.697000													4	11					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5708755	5708755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5708755C>T	ENST00000546188.1	-	21	2202	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	ANO2_ENST00000356134.5_Missense_Mutation_p.E711K|ANO2_ENST00000327087.8_Missense_Mutation_p.E710K			Q9NQ90	ANO2_HUMAN	anoctamin 2	715						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TCTCCAGCTTCGGTCTCATCT	0.453000													34	78					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71707097	71707097	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71707097G>A	ENST00000356340.3	+	36	2560	c.2025_splice	c.e36+1	p.R675_splice	COL13A1_ENST00000517713.1_Splice_Site_p.R626_splice|COL13A1_ENST00000398973.3_Splice_Site_p.R649_splice|COL13A1_ENST00000398972.3_Splice_Site_p.R661_splice|COL13A1_ENST00000357811.3_Splice_Site_p.R641_splice|COL13A1_ENST00000398966.3_Splice_Site_p.R653_splice|COL13A1_ENST00000522165.1_Splice_Site_p.R644_splice|COL13A1_ENST00000398971.3_Splice_Site_p.R660_splice|COL13A1_ENST00000520133.1_Splice_Site_p.R597_splice|COL13A1_ENST00000520267.1_Splice_Site_p.R603_splice|COL13A1_ENST00000398968.3_Splice_Site_p.R656_splice|COL13A1_ENST00000398978.3_Splice_Site_p.R675_splice|COL13A1_ENST00000398974.3_Splice_Site_p.R663_splice|COL13A1_ENST00000398964.3_Splice_Site_p.R646_splice|COL13A1_ENST00000354547.3_Splice_Site_p.R653_splice|COL13A1_ENST00000398969.3_Splice_Site_p.R603_splice			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	675	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AAGGGAAACCGGGTGAGTCTG	0.512000													10	44					0	0	1	0	0
NOMO1	23420	broad.mit.edu	37	16	14989431	14989431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:14989431G>A	ENST00000287667.7	+	31	3769	c.3598G>A	c.(3598-3600)Gca>Aca	p.A1200T		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	1200						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						GCTCGGCCAGGCAGCCTCTGA	0.537000													64	627					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70461399	70461399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:70461399C>T	ENST00000327305.6	-	6	1249	c.592G>A	c.(592-594)Gag>Aag	p.E198K	NETO1_ENST00000299430.2_Missense_Mutation_p.E197K|NETO1_ENST00000583169.1_Missense_Mutation_p.E198K	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	198	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TCAACAGCCTCGCTAGCAGTA	0.458000													18	143					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4835910	4835910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4835910G>A	ENST00000252318.2	+	2	761	c.424G>A	c.(424-426)Gac>Aac	p.D142N	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	142						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						GGCGGCCCAGGACCTCTTCCG	0.552000													21	49					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74276190	74276190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74276190G>A	ENST00000262765.5	-	12	4353	c.4174C>T	c.(4174-4176)Cgg>Tgg	p.R1392W		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1392							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						GATTTCCACCGATCCTCCAGC	0.672000													25	76					0	0	1	0	0
CRY1	1407	broad.mit.edu	37	12	107395596	107395596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107395596G>A	ENST00000008527.5	-	4	1408	c.541C>T	c.(541-543)Cct>Tct	p.P181S		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	181					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						TCAGACAGAGGAGTTGTGCAC	0.398000													45	139					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438833	179438833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179438833C>T	ENST00000589042.1	-	326	72250	c.72026G>A	c.(72025-72027)aGt>aAt	p.S24009N	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S21441N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S22368N|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S15136N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S15069N|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S14944N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22368	Fibronectin type-III 74.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATGGTGGACTGATGGCACC	0.418000													31	61					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36759570	36759570	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36759570C>T	ENST00000416516.2	-	4	2174	c.1684G>A	c.(1684-1686)Gag>Aag	p.E562K		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	562	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TTAAAGAGCTCGTCCTGGTCC	0.552000													32	225					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20658726	20658726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20658726C>T	ENST00000525748.1	+	12	2019	c.1746C>T	c.(1744-1746)acC>acT	p.T582T	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	582				T -> S (in Ref. 2; AAD27892).	synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	AGTTTGCCACCATCGAGACCA	0.493000													33	125					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57118354	57118354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57118354C>T	ENST00000263314.2	+	8	858	c.824C>T	c.(823-825)tCc>tTc	p.S275F		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	275					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity	p.S275Y(1)		endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						AGCAGCGTGTCCCCAGGCTAC	0.552000													17	74					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50850753	50850753	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:50850753C>T	ENST00000404971.1	-	7	2271	c.931_splice	c.e7-1	p.G311_splice	NRXN1_ENST00000402717.3_Splice_Site_p.R278_splice|NRXN1_ENST00000401669.2_Splice_Site_p.G278_splice|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Splice_Site_p.G278_splice|NRXN1_ENST00000405472.3_Splice_Site_p.G278_splice|NRXN1_ENST00000406859.3_Splice_Site_p.R278_splice	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	278	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TTCTTCTTTTCCTAGAGGAAA	0.363000													12	21					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473712	19473712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:19473712C>T	ENST00000507958.1	-	15	2986	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K	CDH18_ENST00000506372.1_3'UTR|CDH18_ENST00000510297.1_5'UTR|CDH18_ENST00000382275.1_Missense_Mutation_p.E666K|CDH18_ENST00000274170.4_Missense_Mutation_p.E666K|CDH18_ENST00000502796.1_3'UTR			Q13634	CAD18_HUMAN	cadherin 18, type 2	666					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TCTGTGTCTTCCTCTCCGCCT	0.507000													51	145					0	0	1	0	0
RPL10L	140801	broad.mit.edu	37	14	47120402	47120402	+	Missense_Mutation	SNP	C	C	T	rs61745038	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:47120402C>T	ENST00000298283.3	-	1	626	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	180					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome	p.E180K(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						TCTTCAAATTCGTCAGCATTA	0.517000													50	99					0	0	1	0	0
KLRG1	10219	broad.mit.edu	37	12	9144893	9144893	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9144893G>A	ENST00000266551.4	+	2	189	c.174G>A	c.(172-174)tgG>tgA	p.W58*	KLRG1_ENST00000538029.1_Intron|KLRG1_ENST00000356986.3_Nonsense_Mutation_p.W58*|RP11-259O18.4_ENST00000545706.1_RNA	NM_005810.3	NP_005801.3	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G, member 1	58			W -> R (in dbSNP:rs1805749).		cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			breast(1)|central_nervous_system(1)|kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8						TATACCAGTGGATCCTGTGCC	0.388000													78	170					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126732423	126732423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:126732423C>T	ENST00000274473.6	+	7	879	c.612C>T	c.(610-612)gaC>gaT	p.D204D	MEGF10_ENST00000508365.1_Silent_p.D204D|MEGF10_ENST00000418761.2_Silent_p.D204D|MEGF10_ENST00000503335.2_Silent_p.D204D	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	204	EGF-like 3.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CCACCTGCGACCACGTCACGG	0.637000													18	78					0	0	1	0	0
BMX	660	broad.mit.edu	37	X	15549483	15549483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:15549483G>A	ENST00000357607.2	+	11	1160	c.972G>A	c.(970-972)tcG>tcA	p.S324S	BMX_ENST00000342014.6_Silent_p.S324S|BMX_ENST00000348343.6_Silent_p.S324S			P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	324	SH2.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(14)|ovary(2)|urinary_tract(3)	30	Hepatocellular(33;0.183)					TTAGAAATTCGAGCCAAGTGG	0.323000													33	57					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30316198	30316198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:30316198G>A	ENST00000361371.4	-	23	4161	c.4011C>T	c.(4009-4011)tcC>tcT	p.S1337S	LTN1_ENST00000389194.2_Silent_p.S1383S	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	1337							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						CATTCTGAAAGGATGTTTCAG	0.358000													43	112					0	0	1	0	0
BAP1	8314	broad.mit.edu	37	3	52441424	52441424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52441424C>T	ENST00000460680.1	-	6	899	c.428G>A	c.(427-429)aGc>aAc	p.S143N	BAP1_ENST00000296288.5_Missense_Mutation_p.S143N	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	143					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CCTGGCATGGCTATTATGGGC	0.537000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							31	91					0	0	1	0	0
IGHV5-51	28388	broad.mit.edu	37	14	107034953	107034953	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107034953C>T	ENST00000390626.2	-	0	185																											TATCCAGAACCCTTACAGGAG	0.567000													10	30					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431164	56431164	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56431164G>A	ENST00000302969.2	+	1	27	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						TTGAAGCAATGGATAAAGAAA	0.398000													40	151					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124351444	124351444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124351444G>A	ENST00000360013.3	+	35	5481	c.5354G>A	c.(5353-5355)gGa>gAa	p.G1785E	KALRN_ENST00000428018.2_Missense_Mutation_p.G88E|KALRN_ENST00000393496.1_Missense_Mutation_p.G158E|KALRN_ENST00000291478.4_Missense_Mutation_p.G88E	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1785					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AAGGCAGATGGAAACATCAAA	0.552000													47	82					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310132	57310132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57310132G>A	ENST00000457912.1	+	2	71	c.71G>A	c.(70-72)gGg>gAg	p.G24E	SMTNL1_ENST00000399154.2_Missense_Mutation_p.G6E|SMTNL1_ENST00000527972.1_Missense_Mutation_p.G6E			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	6										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						CAGAAGGAAGGGAAGCTCTCT	0.602000													6	26					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860953	16860953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16860953C>T	ENST00000524140.2	+	6	1918	c.1500C>T	c.(1498-1500)ggC>ggT	p.G500G	NWD1_ENST00000523826.1_Silent_p.G294G|NWD1_ENST00000379808.3_Silent_p.G500G|NWD1_ENST00000552788.1_Silent_p.G500G|NWD1_ENST00000339803.6_Silent_p.G365G|NWD1_ENST00000549814.1_Silent_p.G500G	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	500	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAAACCAAGGCCAGCAGATGA	0.637000													9	83					0	0	1	0	0
SPAG4	6676	broad.mit.edu	37	20	34206880	34206880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34206880G>A	ENST00000374273.3	+	8	865	c.753G>A	c.(751-753)gaG>gaA	p.E251E		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	251					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity			NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GGCTGAATGAGGATTTTGTGC	0.592000													18	50					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634394	156634394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156634394G>A	ENST00000296518.7	+	7	1440	c.1231G>A	c.(1231-1233)Gat>Aat	p.D411N	GUCY1A3_ENST00000393832.3_Missense_Mutation_p.D153N|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.D411N|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.D411N|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.D411N|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.D411N|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.D411N			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	411					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity	p.R410>?(1)		central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TGCACTGAGGGATGTGGTCTT	0.517000													23	56					0	0	1	0	0
BSND	7809	broad.mit.edu	37	1	55473947	55473947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55473947G>A	ENST00000371265.4	+	4	863	c.609G>A	c.(607-609)atG>atA	p.M203I		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	203						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						ACCTGGACATGGACTCCAGTG	0.617000													16	39					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28992873	28992873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28992873C>T	ENST00000359747.4	+	15	2524	c.2495C>T	c.(2494-2496)tCt>tTt	p.S832F	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.S813F|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	813					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGAGTCGGGTCTCCCGTAGGC	0.428000													30	87					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992412	85992412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85992412C>T	ENST00000372105.3	-	4	1164	c.1143G>A	c.(1141-1143)agG>agA	p.R381R		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	381						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GGGGGACATGCCTGGCCACCA	0.607000													8	25					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1551584	1551584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1551584C>T	ENST00000381605.4	-	4	1015	c.951G>A	c.(949-951)gtG>gtA	p.V317V	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000262929.5_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	317	Ig-like C1-type 2.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CACAGGTGTTCACCAGGAGCC	0.552000													17	135					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578277	7578277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7578277G>A	ENST00000420246.2	-	6	704	c.572C>T	c.(571-573)cCt>cTt	p.P191L	TP53_ENST00000445888.2_Missense_Mutation_p.P191L|TP53_ENST00000269305.4_Missense_Mutation_p.P191L|TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.P191L|TP53_ENST00000455263.2_Missense_Mutation_p.P191L|TP53_ENST00000413465.2_Missense_Mutation_p.P191L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	191	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.P191del(7)|p.?(6)|p.P191delP(4)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.P191L(2)|p.P191R(2)|p.G187fs*16(2)|p.P59delP(2)|p.P98delP(2)|p.P191fs*56(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P191H(1)|p.P191_Q192delPQ(1)|p.D186_P191delDGLAPP(1)|p.P98_E105>Q(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.L188_P191del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAGATGCTGAGGAGGGGCCAG	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	22					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98413354	98413354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98413354G>A	ENST00000186436.5	-	27	3194	c.2966C>T	c.(2965-2967)tCc>tTc	p.S989F		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	989						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						AAAGCGTAAGGAGCTTCCTGG	0.423000													23	56					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110819517	110819517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110819517G>A	ENST00000375820.4	-	44	4058	c.3937C>T	c.(3937-3939)Cca>Tca	p.P1313S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1313	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TGAAATCCTGGAACTCCTGGA	0.527000													54	160					0	0	1	0	0
GLIPR1	11010	broad.mit.edu	37	12	75874745	75874745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:75874745G>A	ENST00000266659.3	+	1	286	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K		NM_006851.2	NP_006842.2	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1	29					cellular lipid metabolic process	extracellular region|integral to membrane		p.E29K(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	14						GCCAGATATCGAAAATGAAGA	0.403000													14	76					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647813	51647813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51647813C>T	ENST00000317643.6	+	2	653	c.584C>T	c.(583-585)tCc>tTc	p.S195F	SIGLEC7_ENST00000600577.1_Intron|SIGLEC7_ENST00000305628.7_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	195	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CTGCACCCCTCCACCACCCGC	0.667000													54	107					0	0	1	0	0
WDR45B	56270	broad.mit.edu	37	17	80579641	80579641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80579641G>A	ENST00000392325.4	-	6	656	c.462C>T	c.(460-462)tcC>tcT	p.S154S	WDR45B_ENST00000571835.1_5'UTR	NM_019613.3	NP_062559.2			WD repeat domain 45B																		AGGCCAGGAGGGAGTTGTTAC	0.572000													11	33					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12836064	12836064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12836064C>T	ENST00000357726.4	+	2	693	c.666C>T	c.(664-666)ttC>ttT	p.F222F		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	222										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTATAAGGTTCGCCCCTTACC	0.527000													62	126					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004453	41004453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41004453C>T	ENST00000399564.4	-	37	4639	c.4189G>A	c.(4189-4191)Gaa>Aaa	p.E1397K	MROH2B_ENST00000506092.2_Missense_Mutation_p.E952K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CTTACATCTTCAAAGAAGGTC	0.458000													50	96					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450355	158450355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158450355C>T	ENST00000368152.1	+	1	688	c.688C>T	c.(688-690)Ccc>Tcc	p.P230S	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					ACTTGTGGTTCCCTTTCTGTT	0.438000													35	140					0	0	1	0	0
OR3A4P	390756	broad.mit.edu	37	17	3213706	3213706	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3213706C>T	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							TTGTCATCTTCCTTCTTGCTT	0.527000													24	39					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27703020	27703020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27703020G>A	ENST00000438700.3	-	1	277	c.160C>T	c.(160-162)Ccc>Tcc	p.P54S		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	54					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GAGGGTTCGGGGGATTTCGGG	0.697000													35	82					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172834990	172834990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172834990C>T	ENST00000351008.3	-	2	715	c.532G>A	c.(532-534)Gta>Ata	p.V178I		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	178					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TTTAAGGCTACCTGAAGCCAT	0.438000													19	162					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82835440	82835440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82835440C>T	ENST00000265077.3	+	8	7183	c.6618C>T	c.(6616-6618)ttC>ttT	p.F2206F	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.F1219F|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2206	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CACATTTTTTCTTAGCTACTG	0.373000													35	98					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131750420	131750420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131750420C>T	ENST00000372577.2	+	24	2509	c.2488C>T	c.(2488-2490)Cct>Tct	p.P830S		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	830					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						GCTGAAACCTCCTTCTAATGT	0.498000													54	188					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248789634	248789634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248789634C>T	ENST00000330803.2	-	1	857	c.796G>A	c.(796-798)Gag>Aag	p.E266K		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGTCCTGCTCGGGGGTGTGG	0.502000													22	74					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179718276	179718276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179718276C>T	ENST00000420890.2	-	20	3253	c.3136G>A	c.(3136-3138)Gaa>Aaa	p.E1046K	CCDC141_ENST00000295723.5_Missense_Mutation_p.E471K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	471							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTCACAGCTTCCTTTGTCTTG	0.423000													33	80					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52604519	52604519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52604519C>T	ENST00000521776.2	+	2	2312	c.1579C>T	c.(1579-1581)Ccc>Tcc	p.P527S		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	527					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TAAGGAGCTTCCCAGACCTGT	0.468000													71	138					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879171	3879171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3879171C>T	ENST00000315677.3	-	4	1493	c.898G>A	c.(898-900)Gac>Aac	p.D300N	DLGAP1-AS3_ENST00000577649.1_RNA|DLGAP1_ENST00000581527.1_Missense_Mutation_p.D300N|DLGAP1_ENST00000515196.2_Missense_Mutation_p.D300N|DLGAP1_ENST00000584874.1_Missense_Mutation_p.D300N	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	300					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				ATGGCCTGGTCCATGTTCACC	0.592000													15	54					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139907193	139907193	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139907193G>A	ENST00000265662.5	-	31	5199	c.5052C>T	c.(5050-5052)ctC>ctT	p.L1684L	ABCA2_ENST00000371605.3_Silent_p.L1683L|ABCA2_ENST00000341511.6_Silent_p.L1684L			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1683					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGGAGGTGAAGAGCAGGTACT	0.672000													14	49					0	0	1	0	0
SYN3	8224	broad.mit.edu	37	22	32914070	32914070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32914070C>T	ENST00000358763.2	-	13	1812	c.1570G>A	c.(1570-1572)Gaa>Aaa	p.E524K	SYN3_ENST00000467095.1_5'UTR|SYN3_ENST00000332840.5_Missense_Mutation_p.E524K	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	524	J; Pro-rich linker.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						TTGGACTCTTCACCCTGCTGG	0.602000													32	71					0	0	1	0	0
MIR363	574031	broad.mit.edu	37	X	133303440	133303440	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:133303440C>T	ENST00000384840.1	-	0	42					NR_029852.1																						AATTTTTCTCCTATGATACTC	0.388000													23	31					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176762775	176762775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176762775G>A	ENST00000367662.3	+	20	6264	c.5100G>A	c.(5098-5100)ctG>ctA	p.L1700L		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1700	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CTGACACTCTGGAGCACTGGA	0.473000													24	66					0	0	1	0	0
OGFR	11054	broad.mit.edu	37	20	61444719	61444719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61444719C>T	ENST00000370461.1	+	5	3873	c.1596C>T	c.(1594-1596)ccC>ccT	p.P532P	OGFR_ENST00000290291.6_Silent_p.P584P|OGFR_ENST00000370468.3_Intron			Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	584	7 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]- [GR]-D-E-P-A-[EK].				regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity			endometrium(2)|kidney(1)|lung(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	17	Breast(26;3.65e-08)					CCCCAGGCCCCAGCCCGGCAG	0.746000													4	26					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62288742	62288742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62288742G>A	ENST00000378024.4	-	5	13421	c.13147C>T	c.(13147-13149)Ccc>Tcc	p.P4383S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4383					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GAGATTTTGGGGGCCTTGATG	0.483000													89	231					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735176	55735176	+	Missense_Mutation	SNP	G	G	A	rs142455941		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55735176G>A	ENST00000312345.2	-	1	814	c.764C>T	c.(763-765)cCa>cTa	p.P255L		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P255Q(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AAACTGATGTGGTTTGGGCTG	0.393000													20	43					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54578016	54578016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54578016C>T	ENST00000336470.4	+	11	1018	c.879C>T	c.(877-879)gtC>gtT	p.V293V	GNL3L_ENST00000360845.2_Silent_p.V293V	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	293	G.				ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						TGCAGGAGGTCTACCTGGACA	0.587000													6	23					0	0	1	0	0
SELPLG	6404	broad.mit.edu	37	12	109017754	109017754	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109017754C>T	ENST00000388962.3	-	2	489	c.330G>A	c.(328-330)ggG>ggA	p.G110G	SELPLG_ENST00000550948.1_Silent_p.G110G|SELPLG_ENST00000228463.6_Silent_p.G126G	NM_003006.4	NP_002997.2	Q14242	SELPL_HUMAN	selectin P ligand	110					blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(3)|skin(1)	12						TGGACAGGTTCCCCATGTTGG	0.607000													27	50					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97604280	97604280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97604280G>A	ENST00000371203.5	+	4	634	c.47G>A	c.(46-48)aGg>aAg	p.R16K	ENTPD1_ENST00000543964.1_Missense_Mutation_p.R46K|RP11-429G19.3_ENST00000433113.1_RNA|ENTPD1_ENST00000490659.1_3'UTR|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000539125.1_Missense_Mutation_p.R16K|ENTPD1_ENST00000371205.4_Missense_Mutation_p.R154K|ENTPD1_ENST00000371207.3_Missense_Mutation_p.R166K|ENTPD1_ENST00000453258.2_Missense_Mutation_p.R161K	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	154					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		GTGGTGGAGAGGAGCCTCAGC	0.458000													15	188					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	84025043	84025043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:84025043C>T	ENST00000369705.3	-	6	806	c.690G>A	c.(688-690)gaG>gaA	p.E230E	ME1_ENST00000543031.1_Silent_p.E155E|ME1_ENST00000541327.1_Silent_p.E64E	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	230					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AAGAAACTGCCTCCATGAATT	0.308000													34	67					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35803197	35803197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35803197C>T	ENST00000361922.4	+	11	1880	c.1730C>T	c.(1729-1731)tCt>tTt	p.S577F	MAG_ENST00000392213.3_Intron|MAG_ENST00000537831.2_Intron	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	0					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			AAAGAGGTTTCTACCCTGGAA	0.627000													49	107					0	0	1	0	0
B3GALT1	8708	broad.mit.edu	37	2	168725844	168725844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168725844G>A	ENST00000305861.1	+	2	646	c.295G>A	c.(295-297)Gag>Aag	p.E99K	B3GALT1_ENST00000392690.2_Missense_Mutation_p.E99K|AC016723.4_ENST00000436982.2_RNA|AC016723.4_ENST00000430546.1_RNA	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	99					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						GGCAATCAGAGAGACGTGGGG	0.463000													24	79					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67354558	67354558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67354558G>A	ENST00000304372.5	-	2	289	c.234C>T	c.(232-234)tcC>tcT	p.S78S	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	78						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CTGCACAACTGGAGAAGGAGA	0.478000													9	101					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6190872	6190872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6190872G>A	ENST00000530810.1	-	1	766	c.685C>T	c.(685-687)Cgt>Tgt	p.R229C	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGGCAAACGAAACACTGCT	0.478000													17	35					0	0	1	0	0
PIGV	55650	broad.mit.edu	37	1	27124182	27124182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27124182C>T	ENST00000374145.1	+	4	2011	c.1329C>T	c.(1327-1329)tcC>tcT	p.S443S	PIGV_ENST00000449950.2_Silent_p.S215S|PIGV_ENST00000078527.4_Silent_p.S443S	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	443					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CAGAGGACTCCCCACCAGGAC	0.478000													12	65					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40669560	40669560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40669560C>T	ENST00000454349.2	+	7	3308	c.3097C>T	c.(3097-3099)Cac>Tac	p.H1033Y	TNRC6B_ENST00000301923.9_Missense_Mutation_p.H286Y|TNRC6B_ENST00000335727.8_Missense_Mutation_p.H980Y|TNRC6B_ENST00000402203.1_Missense_Mutation_p.H286Y	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1033					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						TGCTTCCTCCCACAACTCAGC	0.552000													4	4					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113075045	113075045	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113075045C>T	ENST00000316851.7	+	2	135	c.135C>T	c.(133-135)ttC>ttT	p.F45F	NCAM1_ENST00000533760.1_5'UTR|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Silent_p.F54F	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	55	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TCTCCTGGTTCTCCCCCAATG	0.468000													8	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179457165	179457165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179457165G>A	ENST00000589042.1	-	301	59791	c.59567C>T	c.(59566-59568)tCt>tTt	p.S19856F	TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S17288F|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S18215F|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S10983F|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S10916F|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S10791F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18215	Ig-like 110.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGTTAAAGAATAAATTCC	0.358000													47	207					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33093395	33093395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33093395G>A	ENST00000307363.5	-	8	1038	c.894C>T	c.(892-894)gcC>gcT	p.A298A	GLB1_ENST00000399402.3_Silent_p.A268A|GLB1_ENST00000445488.2_Silent_p.A346A|GLB1_ENST00000307377.8_Silent_p.A167A	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	298					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				TCGCCCCACGGGCAAGTATAT	0.512000													21	65					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48258241	48258241	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48258241G>A	ENST00000394747.1	-	4	844	c.495C>T	c.(493-495)ttC>ttT	p.F165F	ABCC11_ENST00000394748.1_Silent_p.F165F|ABCC11_ENST00000353782.5_Silent_p.F165F|ABCC11_ENST00000537808.1_Silent_p.F165F|ABCC11_ENST00000356608.2_Silent_p.F165F	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	165	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GAAGTGCATCGAAAATCAACC	0.512000													25	53					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158259858	158259858	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158259858C>T	ENST00000368170.3	+	1	283	c.4C>T	c.(4-6)Ctg>Ttg	p.L2L		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	2					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					AAATGACATGCTGTTTCTGCA	0.438000													27	79					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101715232	101715232	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101715232G>A	ENST00000342239.3	-	4	2090	c.1999C>T	c.(1999-2001)Cgt>Tgt	p.R667C	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Missense_Mutation_p.R667C			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	667					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CAGGTAGGACGGTGTCGAGAT	0.597000													11	31					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53610870	53610870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:53610870G>A	ENST00000342160.3	-	41	5625	c.5168C>T	c.(5167-5169)cCt>cTt	p.P1723L	HUWE1_ENST00000262854.6_Missense_Mutation_p.P1723L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1723					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TAGGGCCAAAGGGGTATCTAT	0.438000													53	33					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67101751	67101751	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67101751G>A	ENST00000284425.2	-	20	2766	c.2592C>T	c.(2590-2592)atC>atT	p.I864I		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	864					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					GGAATATTGCGATTCCAAATA	0.274000													9	48					0	0	1	0	0
MAPK8IP2	23542	broad.mit.edu	37	22	51041867	51041867	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:51041867C>T	ENST00000329492.3	+	3	504	c.387C>T	c.(385-387)tcC>tcT	p.S129S	MAPK8IP2_ENST00000399908.2_5'UTR|MAPK8IP2_ENST00000341339.4_Intron|MAPK8IP2_ENST00000008876.5_Silent_p.S102S|MAPK8IP2_ENST00000399912.1_5'UTR|MAPK8IP2_ENST00000442429.2_Silent_p.S129S	NM_012324.3	NP_036456.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	129	JNK-binding domain (JBD).				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTCCCCTTCCGTGGAGGAGC	0.697000													6	9					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215848384	215848384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215848384C>T	ENST00000272895.7	-	29	4588	c.4369G>A	c.(4369-4371)Gag>Aag	p.E1457K	ABCA12_ENST00000389661.4_Missense_Mutation_p.E1139K	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1457	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTTACTTCCTCGTGGAGCTGC	0.433000													16	77					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	344285	344285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:344285G>A	ENST00000343164.4	-	7	854	c.802C>T	c.(802-804)Cca>Tca	p.P268S	SLC6A13_ENST00000445055.2_Missense_Mutation_p.P176S	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	268					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GTGAGGTTTGGGTACAGGTAA	0.557000													15	67					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48762861	48762861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48762861C>T	ENST00000316623.5	-	36	4884	c.4429G>A	c.(4429-4431)Gaa>Aaa	p.E1477K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1477	EGF-like 25; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CTGTCCAGTTCGTAGCCTATC	0.567000													28	60					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33152024	33152024	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33152024G>A	ENST00000341947.2	-	8	1244	c.1017C>T	c.(1015-1017)ccC>ccT	p.P339P	COL11A2_ENST00000374714.1_Silent_p.P313P|COL11A2_ENST00000361917.1_Intron|COL11A2_ENST00000395197.1_Intron|COL11A2_ENST00000374713.1_Silent_p.P292P|COL11A2_ENST00000374712.1_Intron|COL11A2_ENST00000374708.4_Intron|COL11A2_ENST00000357486.1_Silent_p.P318P	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	339	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GCCCTTCAGGGGGGTCTGTGC	0.612000													37	92					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12939479	12939479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12939479G>A	ENST00000393233.2	-	5	782	c.233C>T	c.(232-234)gCc>gTc	p.A78V	RTBDN_ENST00000322912.5_Silent_p.C151C|RTBDN_ENST00000458671.2_Silent_p.C119C|RTBDN_ENST00000589272.1_Silent_p.C151C|CTD-2265O21.3_ENST00000588469.1_RNA|RTBDN_ENST00000592204.1_Silent_p.C129C	NM_001270440.1	NP_001257369.1	Q9BSG5	RTBDN_HUMAN	retbindin	0						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						ACCAGGCCTGGCAGAGCTCCT	0.652000													9	35					0	0	1	0	0
IGLC7	28834	broad.mit.edu	37	22	23264783	23264783	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23264783C>T	ENST00000390331.1	+	0	18																											CAAGGCTGCCCCCTCGGTCAC	0.622000													17	60					0	0	1	0	0
RASA2	5922	broad.mit.edu	37	3	141292000	141292000	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141292000C>T	ENST00000286364.3	+	13	1331	c.1296C>T	c.(1294-1296)tcC>tcT	p.S432S	RASA2_ENST00000452898.1_Silent_p.S432S			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	432	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						TATGTGACTCCTCAAAATCCT	0.229000													6	61					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206225329	206225329	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206225329T>A	ENST00000367126.4	+	1	1354	c.889T>A	c.(889-891)Ttc>Atc	p.F297I		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	297					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CTGGGCTCCCTTCTTCAGTGT	0.552000													31	69					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66191487	66191487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66191487C>T	ENST00000311034.2	+	7	1302	c.1126C>T	c.(1126-1128)Ccc>Tcc	p.P376S		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	376					transcription, DNA-dependent		DNA binding|signal transducer activity	p.F375_P376>S(1)		breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CACCAGCTTCCCCAGTGCTCC	0.552000													81	188					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430867	43430867	+	RNA	SNP	C	C	T	rs145405049		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43430867C>T	ENST00000446844.3	-	0	800				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TGGGCAGCTTCGCTGTGTGAA	0.473000													59	282					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84564785	84564785	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84564785G>A	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							ATGCCCCACAGGAAGCCTGTG	0.498000													4	7					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140079372	140079372	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140079372G>A	ENST00000323927.2	-	4	1045	c.1041C>T	c.(1039-1041)atC>atT	p.I347I		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	347					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CACCTCGGACGATGCTGAAGA	0.677000													3	26					0	0	1	0	0
GCAT	23464	broad.mit.edu	37	22	38211196	38211196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38211196C>T	ENST00000323205.6	+	5	781	c.718C>T	c.(718-720)Ctg>Ttg	p.L240L	GCAT_ENST00000248924.6_Silent_p.L214L	NM_001171690.1	NP_001165161.1	O75600	KBL_HUMAN	glycine C-acetyltransferase	214					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	12	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CATCGCACCCCTGCAGGAGAT	0.602000													4	42					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43986097	43986097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43986097C>T	ENST00000262726.7	-	24	3142	c.2889G>A	c.(2887-2889)atG>atA	p.M963I	EFCAB6_ENST00000396231.2_Missense_Mutation_p.M811I	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	963					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GATGGCGGTCCATAAGCTTAT	0.383000													32	82					0	0	1	0	0
PLCB3	5331	broad.mit.edu	37	11	64026164	64026164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64026164C>T	ENST00000540288.1	+	11	1335	c.1232C>T	c.(1231-1233)tCc>tTc	p.S411F	PLCB3_ENST00000325234.5_Missense_Mutation_p.S344F|PLCB3_ENST00000279230.6_Missense_Mutation_p.S411F	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	411	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						GTCATCCTCTCCTTCGAGAAC	0.612000													32	53					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115947782	115947782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115947782G>A	ENST00000251864.2	+	2	345	c.192G>A	c.(190-192)aaG>aaA	p.K64K	TDRD1_ENST00000422662.1_5'UTR|TDRD1_ENST00000369281.2_Silent_p.K64K|TDRD1_ENST00000369282.1_Silent_p.K64K|TDRD1_ENST00000369280.1_Silent_p.K64K	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	64					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GAAATAAAAAGAACAATTTTT	0.388000													44	116					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247607993	247607993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247607993C>T	ENST00000366497.2	+	8	3490	c.2710C>T	c.(2710-2712)Ctt>Ttt	p.L904F	NLRP3_ENST00000391828.3_Missense_Mutation_p.L961F|NLRP3_ENST00000336119.3_Missense_Mutation_p.L961F|NLRP3_ENST00000391827.2_Missense_Mutation_p.L904F|NLRP3_ENST00000348069.2_Missense_Mutation_p.L847F|NLRP3_ENST00000366496.2_Missense_Mutation_p.L904F	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	961					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTGCTGGGATCTTTCCACACT	0.527000													22	49					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316036	30316036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30316036G>A	ENST00000375377.1	-	3	3142	c.3041C>T	c.(3040-3042)cCa>cTa	p.P1014L		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	1014										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CGCTTCACTTGGTTTCACAGA	0.567000													58	119					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940609	144940609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144940609G>A	ENST00000525985.1	-	2	6884	c.6813C>T	c.(6811-6813)ttC>ttT	p.F2271F				P58107	EPIPL_HUMAN	epiplakin 1	2271						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTCGATGACGAAGCCGGTGG	0.716000													4	48					0	0	1	0	0
PCCB	5096	broad.mit.edu	37	3	135975435	135975435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:135975435C>T	ENST00000471595.1	+	3	360	c.342C>T	c.(340-342)atC>atT	p.I114I	PCCB_ENST00000468777.1_Silent_p.I114I|PCCB_ENST00000469217.1_Silent_p.I114I|PCCB_ENST00000478469.1_Silent_p.I114I|PCCB_ENST00000483687.1_Silent_p.I114I|PCCB_ENST00000251654.4_Silent_p.I114I|PCCB_ENST00000482086.1_Intron|PCCB_ENST00000466072.1_Silent_p.I114I|PCCB_ENST00000490504.1_Silent_p.I114I|PCCB_ENST00000474833.1_Intron|PCCB_ENST00000462637.1_Intron			P05166	PCCB_HUMAN	propionyl CoA carboxylase, beta polypeptide	114	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	25					Biotin(DB00121)|L-Valine(DB00161)	GAGGCCGAATCAATGGAAGAT	0.393000													5	86					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123256123	123256123	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123256123C>T	ENST00000358487.5	-	13	2058	c.1786G>A	c.(1786-1788)Gag>Aag	p.E596K	FGFR2_ENST00000360144.3_Missense_Mutation_p.E508K|FGFR2_ENST00000478859.1_Missense_Mutation_p.E368K|FGFR2_ENST00000369059.1_Missense_Mutation_p.E482K|FGFR2_ENST00000351936.6_Missense_Mutation_p.E594K|FGFR2_ENST00000357555.5_Missense_Mutation_p.E507K|FGFR2_ENST00000369060.4_Missense_Mutation_p.E480K|FGFR2_ENST00000346997.2_Missense_Mutation_p.E594K|FGFR2_ENST00000356226.4_Missense_Mutation_p.E479K|FGFR2_ENST00000457416.2_Missense_Mutation_p.E597K|FGFR2_ENST00000369061.4_Missense_Mutation_p.E484K|FGFR2_ENST00000369056.1_Missense_Mutation_p.E597K	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	596	Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GTCATCTGCTCCTCAGGAACA	0.517000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				90	223					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82416146	82416146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:82416146C>T	ENST00000370728.1	+	9	2117	c.1472C>T	c.(1471-1473)cCa>cTa	p.P491L	LPHN2_ENST00000370723.1_Missense_Mutation_p.P491L|LPHN2_ENST00000335786.5_Missense_Mutation_p.P491L|LPHN2_ENST00000370715.1_Missense_Mutation_p.P491L|LPHN2_ENST00000370725.1_Missense_Mutation_p.P491L|LPHN2_ENST00000359929.3_Missense_Mutation_p.P491L|LPHN2_ENST00000394879.1_Missense_Mutation_p.P491L|LPHN2_ENST00000370727.1_Missense_Mutation_p.P491L|LPHN2_ENST00000370730.1_Missense_Mutation_p.P491L|LPHN2_ENST00000370717.2_Missense_Mutation_p.P491L|LPHN2_ENST00000319517.6_Missense_Mutation_p.P491L|LPHN2_ENST00000370713.1_Missense_Mutation_p.P491L|LPHN2_ENST00000370721.1_Missense_Mutation_p.P429L|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000271029.4_Missense_Mutation_p.P491L			O95490	LPHN2_HUMAN	latrophilin 2	491					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GTTGAACGACCATGCCCTAAG	0.378000													22	67					0	0	1	0	0
GFI1	2672	broad.mit.edu	37	1	92946183	92946183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92946183G>A	ENST00000370332.1	-	4	1079	c.761C>T	c.(760-762)tCc>tTc	p.S254F	GFI1_ENST00000294702.5_Missense_Mutation_p.S254F|GFI1_ENST00000427103.1_Missense_Mutation_p.S254F	NM_001127215.1	NP_001120687.1	Q99684	GFI1_HUMAN	growth factor independent 1 transcription repressor	254					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		GCACTTGTAGGAGCCGCCGCC	0.716000													6	7					0	0	1	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423832	33423832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33423832G>A	ENST00000395064.2	+	2	1223	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	319	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						AGGGGACACTGAAGGGAATGG	0.547000													15	96					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103057133	103057133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103057133C>T	ENST00000375735.2	+	42	6940	c.6796C>T	c.(6796-6798)Cct>Tct	p.P2266S	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.P2266S	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2266	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CATTCAGACTCCTGACATGCA	0.428000													32	40					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73096514	73096514	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73096514C>T	ENST00000450736.2	+	4	1171	c.756C>T	c.(754-756)ttC>ttT	p.F252F	SLC16A5_ENST00000580123.1_Silent_p.F252F|SLC16A5_ENST00000329783.4_Silent_p.F252F|SLC16A5_ENST00000538213.2_Silent_p.F292F			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	252					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity	p.F252L(2)		central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	TCCTGGGCTTCCCACTGCCAC	0.607000													11	46					0	0	1	0	0
ZDHHC11	79844	broad.mit.edu	37	5	843767	843767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:843767G>A	ENST00000283441.8	-	4	959	c.576C>T	c.(574-576)ctC>ctT	p.L192L	ZDHHC11_ENST00000511539.1_5'UTR|ZDHHC11_ENST00000424784.2_Silent_p.L192L	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	192						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GGTACTGGACGAGGACATACA	0.647000													9	37					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53930378	53930378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53930378C>T	ENST00000371445.3	+	3	874	c.819C>T	c.(817-819)ccC>ccT	p.P273P		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	273	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						cactgccgccCCTTCCACCGC	0.677000													27	46					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120922487	120922487	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120922487G>A	ENST00000263713.5	+	22	2176		c.e22+1		EPB41L5_ENST00000488691.1_Splice_Site|EPB41L5_ENST00000443902.2_Splice_Site|EPB41L5_ENST00000452780.1_Splice_Site	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5							cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TGCACCTCAGGTAAATATGCT	0.328000													25	67					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62763514	62763514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62763514C>T	ENST00000336232.2	-	6	1007	c.872G>A	c.(871-873)aGg>aAg	p.R291K	SLC22A8_ENST00000311438.8_Missense_Mutation_p.R291K|SLC22A8_ENST00000545207.1_Missense_Mutation_p.R200K|SLC22A8_ENST00000535878.1_Missense_Mutation_p.R168K|SLC22A8_ENST00000430500.2_Missense_Mutation_p.R291K	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	291					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CAAGCTGAGCCTTTCTCCCTC	0.587000													10	127					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163250956	163250956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163250956C>T	ENST00000332142.5	-	12	2752	c.2653G>A	c.(2653-2655)Gga>Aga	p.G885R		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	885					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CAGTTGTCTCCTTCTGAATCA	0.333000													25	68					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31587038	31587038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31587038C>T	ENST00000379416.3	-	24	2665	c.2617G>A	c.(2617-2619)Gat>Aat	p.D873N		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	873					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGAGAGAGATCCTGGGTGTTC	0.572000													17	51					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226483628	226483628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226483628C>T	ENST00000328205.5	-	4	772	c.227G>A	c.(226-228)cGa>cAa	p.R76Q	LIN9_ENST00000366801.1_Intron|LIN9_ENST00000481685.1_Intron	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	60	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		AAGTCGACTTCGTTTTGAATT	0.348000													5	83					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943463	72943463	+	Missense_Mutation	SNP	G	G	A	rs113286281		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72943463G>A	ENST00000328801.4	+	6	1513	c.1513G>A	c.(1513-1515)Ggc>Agc	p.G505S		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	505						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					GCTGGGCCAGGGCCTGCAGCG	0.647000													17	42					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118469492	118469492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:118469492C>T	ENST00000311085.8	+	12	1953	c.1873C>T	c.(1873-1875)Ctc>Ttc	p.L625F	DMXL1_ENST00000539542.1_Missense_Mutation_p.L625F	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	625										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTCTACTGTTCTCAGTATTTC	0.378000													25	147					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140301677	140301677	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:140301677G>A	ENST00000275884.6	-	2	938	c.521C>T	c.(520-522)tCg>tTg	p.S174L	DENND2A_ENST00000496613.1_Missense_Mutation_p.S174L|DENND2A_ENST00000492720.1_Missense_Mutation_p.S174L|DENND2A_ENST00000537639.1_Missense_Mutation_p.S174L			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	174										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					CAGCCCTGCCGACCCATCCTT	0.597000													10	80					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46826217	46826217	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46826217G>A	ENST00000283296.7	-	17	3711	c.3423C>T	c.(3421-3423)gcC>gcT	p.A1141A	GPR116_ENST00000456426.2_Silent_p.A999A|GPR116_ENST00000265417.7_Silent_p.A1141A|GPR116_ENST00000545669.1_Silent_p.A570A|GPR116_ENST00000362015.4_Silent_p.A1141A	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1141					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			TGACCGAGATGGCAAGTGGGC	0.552000													9	40					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3673312	3673312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3673312G>A	ENST00000344754.4	-	15	3885	c.3886C>T	c.(3886-3888)Cac>Tac	p.H1296Y	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.H1296Y	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1296	Ig-like C2-type 13.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CGACCGTTGTGGTACCAAGTA	0.647000													14	36					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702720	30702720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30702720C>T	ENST00000256246.2	-	1	3888	c.3814G>A	c.(3814-3816)Gat>Aat	p.D1272N		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1272										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ACATTTGAATCTAAGACTGAT	0.343000													17	64					0	0	1	0	0
AMICA1	120425	broad.mit.edu	37	11	118071269	118071269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118071269G>A	ENST00000292067.7	-	6	1242	c.801C>T	c.(799-801)atC>atT	p.I267I	AMICA1_ENST00000356289.5_Silent_p.I277I|AMICA1_ENST00000526620.1_Silent_p.I238I|AMICA1_ENST00000533261.1_Silent_p.I266I	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	277					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TTCCCACAATGATCACCAACT	0.512000													29	63					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42028729	42028729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42028729C>T	ENST00000219905.7	+	13	4448	c.4267C>T	c.(4267-4269)Cct>Tct	p.P1423S	MGA_ENST00000570161.1_Missense_Mutation_p.P1423S|MGA_ENST00000545763.1_Missense_Mutation_p.P1423S|MGA_ENST00000389936.4_Missense_Mutation_p.P1423S|MGA_ENST00000566586.1_Missense_Mutation_p.P1423S	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1423						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TCCATTGTCCCCTGGGAAAAT	0.463000													16	33					0	0	1	0	0
ICOSLG	23308	broad.mit.edu	37	21	45656834	45656834	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45656834C>T	ENST00000407780.3	-	3	449	c.322G>A	c.(322-324)Gag>Aag	p.E108K	ICOSLG_ENST00000344330.4_Missense_Mutation_p.E108K|ICOSLG_ENST00000400379.3_Missense_Mutation_p.E108K|ICOSLG_ENST00000400377.3_Intron			O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand	108	Ig-like V-type.				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding			endometrium(2)|lung(1)|stomach(1)|urinary_tract(1)	5				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		AACTTCTGCTCGTCCTGGGGG	0.602000													7	98					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61568741	61568741	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61568741C>T	ENST00000577647.1	+	8	1234	c.1190_splice	c.e8+1	p.R397_splice	ACE_ENST00000290863.6_Splice_Site_p.R397_splice|ACE_ENST00000413513.3_Splice_Site_p.R397_splice|ACE_ENST00000290866.4_Splice_Site_p.R971_splice|ACE_ENST00000490216.2_Splice_Site_p.R397_splice|ACE_ENST00000428043.1_Splice_Site_p.R971_splice|ACE_ENST00000421982.2_Splice_Site_p.R217_splice			P12821	ACE_HUMAN	angiotensin I converting enzyme	971	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CAAGGACTTCCGGTACATCCA	0.607000													36	57					0	0	1	0	0
NFIA	4774	broad.mit.edu	37	1	61824847	61824847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:61824847G>A	ENST00000403491.3	+	6	1331	c.847G>A	c.(847-849)Gat>Aat	p.D283N	NFIA_ENST00000371184.2_Intron|NFIA_ENST00000407417.3_Missense_Mutation_p.D275N|NFIA_ENST00000371185.2_Missense_Mutation_p.D261N|NFIA_ENST00000371189.4_Missense_Mutation_p.D328N|NFIA_ENST00000371191.1_Missense_Mutation_p.D306N|NFIA_ENST00000371187.3_Missense_Mutation_p.D283N|NFIA_ENST00000485903.2_Missense_Mutation_p.D283N|NFIA_ENST00000479364.1_3'UTR	NM_001134673.3|NM_005595.4	NP_001128145.1|NP_005586.1	Q12857	NFIA_HUMAN	nuclear factor I/A	283					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding		NFIA/EHF(2)	endometrium(1)|kidney(2)|large_intestine(8)|lung(20)|pancreas(1)|prostate(1)|skin(1)	34						GTCTGTGGAGGATGAAATGGA	0.512000													14	186					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003043	122003043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122003043C>T	ENST00000498619.1	+	7	2710	c.2272C>T	c.(2272-2274)Ccg>Tcg	p.P758S	CASR_ENST00000296154.5_Missense_Mutation_p.P748S|CASR_ENST00000490131.1_Missense_Mutation_p.P748S	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	748					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CACCGCGCCCCCGTCAAGCTA	0.592000													23	49					0	0	1	0	0
ELK4	2005	broad.mit.edu	37	1	205592886	205592886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205592886G>A	ENST00000357992.4	-	2	464	c.125C>T	c.(124-126)gCt>gTt	p.A42V	ELK4_ENST00000289703.4_Missense_Mutation_p.A42V|ELK4_ENST00000468523.1_5'UTR	NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CCAGAGACGAGCCACCTCTTC	0.468000			T	SLC45A3	prostate								71	161					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149513291	149513291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149513291G>A	ENST00000261799.4	-	6	1261	c.792C>T	c.(790-792)ttC>ttT	p.F264F		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	264	Ig-like C2-type 3.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TATCCAAGAGGAAGTCAGTCA	0.602000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								42	112					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31374319	31374319	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31374319A>T	ENST00000328111.2	+	5	639	c.318A>T	c.(316-318)cgA>cgT	p.R106R	DNMT3B_ENST00000443239.3_Intron|DNMT3B_ENST00000201963.3_Silent_p.R118R|DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000348286.2_Silent_p.R106R|DNMT3B_ENST00000344505.4_Silent_p.R106R|DNMT3B_ENST00000353855.2_Silent_p.R106R|DNMT3B_ENST00000375623.4_Intron	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	106	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCCGAACTCGAAATAACAACA	0.632000													18	55					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71483463	71483463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71483463G>A	ENST00000393539.2	-	6	1278	c.465C>T	c.(463-465)ctC>ctT	p.L155L	AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000564528.1_Silent_p.L97L|RP11-510M2.10_ENST00000576258.1_RNA|ZNF23_ENST00000417828.1_Silent_p.L155L|ZNF23_ENST00000497160.1_3'UTR|ZNF23_ENST00000428724.2_Silent_p.L97L|ZNF23_ENST00000357254.4_Silent_p.L155L|ZNF23_ENST00000539742.1_5'UTR	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		CATGCTTCACGAGTTTTGTAT	0.393000													27	91					0	0	1	0	0
INSL6	11172	broad.mit.edu	37	9	5185414	5185414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:5185414C>T	ENST00000381641.3	-	1	254	c.189G>A	c.(187-189)cgG>cgA	p.R63R		NM_007179.2	NP_009110.2	Q9Y581	INSL6_HUMAN	insulin-like 6	63						extracellular region	hormone activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(2)	15	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		GTGCAATCAACCGTGAGAAAG	0.572000													48	86					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74394620	74394620	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:74394620G>A	ENST00000429810.2	-	0	345																											CTCCACAGACGACCACCTGTG	0.582000													13	67					0	0	1	0	0
ANXA3	306	broad.mit.edu	37	4	79507429	79507429	+	Missense_Mutation	SNP	G	G	A	rs144530066	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79507429G>A	ENST00000264908.6	+	6	707	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	ANXA3_ENST00000503570.2_Missense_Mutation_p.E71K|ANXA3_ENST00000512884.1_Missense_Mutation_p.E71K	NM_005139.2	NP_005130.1	P12429	ANXA3_HUMAN	annexin A3	110					defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						GGGAACAAACGAAGATGCCTT	0.343000													28	100					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71485759	71485759	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:71485759C>T	ENST00000304743.2	+	12	3476	c.3030C>T	c.(3028-3030)gtC>gtT	p.V1010V	PCNX_ENST00000439984.3_Silent_p.V899V|PCNX_ENST00000238570.5_Silent_p.V1010V	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1010						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGTTAGCTGTCATCCTGGCTA	0.398000													49	130					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17927185	17927185	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:17927185G>A	ENST00000448223.2	-	3	298	c.29C>T	c.(28-30)tCc>tTc	p.S10F	SMC6_ENST00000351948.4_Missense_Mutation_p.S10F|SMC6_ENST00000402989.1_Missense_Mutation_p.S10F|SMC6_ENST00000381272.4_Missense_Mutation_p.S10F	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	10					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTTAGGAGAGGAAAAATTTTC	0.328000													7	25					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46946318	46946318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46946318G>A	ENST00000429979.1	-	3	897	c.293C>T	c.(292-294)tCc>tTc	p.S98F	KIAA0226L_ENST00000378784.4_Missense_Mutation_p.S31F|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.S98F|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.S98F|KIAA0226L_ENST00000534925.1_5'UTR|KIAA0226L_ENST00000409879.2_Intron|KIAA0226L_ENST00000480935.1_5'UTR|KIAA0226L_ENST00000322896.6_Intron|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.S98F|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.S98F	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	98	Ser-rich.									NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						CTCTGCCAGGGAGTCCCCGAG	0.572000													31	61					0	0	1	0	0
APOL3	80833	broad.mit.edu	37	22	36556853	36556853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36556853G>A	ENST00000349314.2	-	1	124	c.87C>T	c.(85-87)ttC>ttT	p.F29F	APOL3_ENST00000424878.2_Intron|APOL3_ENST00000397287.2_Intron|APOL3_ENST00000361710.2_Intron|APOL3_ENST00000397293.2_5'UTR	NM_145640.2	NP_663615.1	O95236	APOL3_HUMAN	apolipoprotein L, 3	29					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity			endometrium(2)|large_intestine(1)|lung(1)|stomach(1)	5						ACCCAAAAGGGAAAGTGAAAG	0.537000													24	49					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	946159	946159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:946159C>T	ENST00000264771.4	+	7	568	c.383C>T	c.(382-384)tCg>tTg	p.S128L	TMEM175_ENST00000508204.1_Missense_Mutation_p.S46L|TMEM175_ENST00000515740.1_Missense_Mutation_p.S12L|TMEM175_ENST00000504180.1_3'UTR	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	128						integral to membrane		p.S128L(1)		NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TAACAGTTTTCGTTAATGGTG	0.562000													27	140					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	185969700	185969700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185969700C>T	ENST00000265022.3	-	19	2148	c.1609G>A	c.(1609-1611)Ggg>Agg	p.G537R	DGKG_ENST00000344484.4_Missense_Mutation_p.G512R|DGKG_ENST00000544847.1_Missense_Mutation_p.G478R|DGKG_ENST00000382164.4_Missense_Mutation_p.G498R	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	537	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity	p.G537W(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AAGCTGCCCCCTTCATAACCT	0.527000													11	93					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004186	75004186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:75004186C>T	ENST00000373359.2	-	1	893	c.701G>A	c.(700-702)cGa>cAa	p.R234Q		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	234	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTCCAAGAATCGCATGCACAC	0.488000													25	26					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54687454	54687454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54687454G>A	ENST00000245615.1	-	5	923	c.443C>T	c.(442-444)tCc>tTc	p.S148F	MBOAT7_ENST00000338624.6_Missense_Mutation_p.S75F|MBOAT7_ENST00000431666.2_Missense_Mutation_p.S75F|MBOAT7_ENST00000474910.1_5'UTR|MBOAT7_ENST00000391754.1_Missense_Mutation_p.S148F	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	148					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CTCCATCAGGGAGGGCACGTC	0.617000													10	78					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17449365	17449365	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17449365C>T	ENST00000324894.8	+	4	474	c.406C>T	c.(406-408)Cga>Tga	p.R136*	GTPBP3_ENST00000361619.5_Nonsense_Mutation_p.R158*|GTPBP3_ENST00000598038.1_3'UTR|GTPBP3_ENST00000600625.1_Nonsense_Mutation_p.R136*|GTPBP3_ENST00000358792.7_Nonsense_Mutation_p.R136*	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	136					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						GCCAGGGCTTCGACCGGCGGA	0.652000													14	55					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47515712	47515712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47515712G>A	ENST00000371901.3	+	12	1646	c.1396G>A	c.(1396-1398)Gta>Ata	p.V466I	CYP4X1_ENST00000538609.1_Missense_Mutation_p.V465I	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	466						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						TGAGTTAAAGGTAACCATTGC	0.438000													55	120					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64263654	64263654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:64263654G>A	ENST00000261891.3	-	3	426	c.421C>T	c.(421-423)Cac>Tac	p.H141Y	DAPK2_ENST00000558069.1_Missense_Mutation_p.H141Y|DAPK2_ENST00000558482.1_5'UTR|DAPK2_ENST00000457488.1_Missense_Mutation_p.H141Y			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	141	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		TTCTTTGTGTGAAGGTAGTTC	0.483000													24	338					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70954525	70954525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70954525C>T	ENST00000334414.6	-	17	4402	c.4358G>A	c.(4357-4359)gGa>gAa	p.G1453E	PTPRB_ENST00000550358.1_Missense_Mutation_p.G1365E|PTPRB_ENST00000551525.1_Missense_Mutation_p.G1452E|PTPRB_ENST00000261266.5_Missense_Mutation_p.G1235E|PTPRB_ENST00000451516.2_Missense_Mutation_p.G1145E|PTPRB_ENST00000538708.1_Missense_Mutation_p.G1145E|PTPRB_ENST00000550857.1_Missense_Mutation_p.G1145E	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1235	Fibronectin type-III 17.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTACTTCCTTCCAGGAACAAG	0.498000													15	43					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41608021	41608021	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41608021G>A	ENST00000313860.7	+	6	540	c.486_splice	c.e6+1	p.K162_splice	LIMCH1_ENST00000513024.1_Splice_Site_p.K3_splice|LIMCH1_ENST00000512946.1_Splice_Site_p.K162_splice|LIMCH1_ENST00000512820.1_Splice_Site_p.K162_splice|LIMCH1_ENST00000508501.1_Splice_Site_p.K162_splice|LIMCH1_ENST00000509638.1_Splice_Site_p.K3_splice|LIMCH1_ENST00000503057.1_Splice_Site_p.K3_splice|LIMCH1_ENST00000512632.1_Splice_Site_p.K162_splice|LIMCH1_ENST00000511496.1_Splice_Site_p.K3_splice	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	162					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						AGATGCGAAAGGTAACTTGGC	0.433000													10	31					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825532	4825532	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4825532G>A	ENST00000380382.1	-	1	315	c.316C>T	c.(316-318)Cag>Tag	p.Q106*	MMP26_ENST00000477339.1_Intron|OR52R1_ENST00000356069.2_Nonsense_Mutation_p.Q27*|MMP26_ENST00000380390.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCCACAACTGGAAACTCTCC	0.498000													13	43					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155566292	155566292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:155566292G>A	ENST00000295101.2	+	2	1357	c.880G>A	c.(880-882)Gag>Aag	p.E294K	KCNJ3_ENST00000493505.1_3'UTR|KCNJ3_ENST00000544049.1_Intron	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	294					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	TGAACAGTTCGAGATTGTCGT	0.408000													17	67					0	0	1	0	0
GLT8D2	83468	broad.mit.edu	37	12	104387281	104387281	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104387281C>T	ENST00000360814.4	-	10	1174	c.767_splice	c.e10-1	p.E257_splice	GLT8D2_ENST00000548660.1_Splice_Site_p.E257_splice|GLT8D2_ENST00000546436.1_Splice_Site_p.E257_splice	NM_031302.3	NP_112592.1	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	257						integral to membrane	transferase activity, transferring glycosyl groups			kidney(3)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						TAGAGGTTTTCCCTAAGAAAT	0.438000													9	25					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159163754	159163754	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159163754G>A	ENST00000368125.4	+	5	772	c.615G>A	c.(613-615)gcG>gcA	p.A205A	CADM3_ENST00000368124.4_Silent_p.A239A	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	205	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity	p.A239A(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					ATGATGGGGCGAGCATCGTGT	0.502000													29	59					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760190	115760190	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:115760190C>T	ENST00000427548.1	-	0	1623							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										AGTATGGATTCTCTCATGATT	0.383000													17	28					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128680643	128680643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128680643G>A	ENST00000344954.6	+	9	1408	c.1020G>A	c.(1018-1020)ccG>ccA	p.P340P	FLI1_ENST00000429175.2_Silent_p.P373P|FLI1_ENST00000525560.1_Silent_p.P180P|FLI1_ENST00000281428.8_Silent_p.P307P|FLI1_ENST00000534087.1_Silent_p.P340P			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	373					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		AGCCACATCCGACCGAGTCGT	0.478000			T	EWSR1	Ewing sarcoma								10	40					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53664532	53664532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53664532C>T	ENST00000257934.4	+	5	1410	c.1319C>T	c.(1318-1320)gCc>gTc	p.A440V	ESPL1_ENST00000552462.1_Missense_Mutation_p.A440V	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	440					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						ATGCTGGAGGCCTTAGAGGGC	0.552000													33	76					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139216447	139216447	+	Silent	SNP	C	C	T	rs143306197		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139216447C>T	ENST00000274710.3	+	10	1660	c.1455C>T	c.(1453-1455)ttC>ttT	p.F485F		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	485					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity	p.F485F(1)		breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAAGTTCGGGACAGGCA	0.607000													36	71					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082977	9082977	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9082977C>T	ENST00000397910.4	-	1	9041	c.8838G>A	c.(8836-8838)aaG>aaA	p.K2946K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2947	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACTTATGGCCTTTGTGGAAG	0.498000													24	66					0	0	1	0	0
TMEM82	388595	broad.mit.edu	37	1	16069654	16069654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16069654C>T	ENST00000375782.1	+	3	439	c.301C>T	c.(301-303)Ctc>Ttc	p.L101F	TMEM82_ENST00000465575.1_3'UTR|RP11-169K16.4_ENST00000418525.1_RNA	NM_001013641.1	NP_001013663.1	A0PJX8	TMM82_HUMAN	transmembrane protein 82	101	Leu-rich.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|lung(5)|prostate(1)|skin(1)	13		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CGAGTTCTCCCTCCGGGCCGT	0.711000													13	26					0	0	1	0	0
KRTAP19-3	337970	broad.mit.edu	37	21	31864206	31864206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31864206C>T	ENST00000334063.4	-	1	69	c.70G>A	c.(70-72)Ggc>Agc	p.G24S		NM_181609.3	NP_853640.1	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	24						intermediate filament				large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	9						CAGCCATAGCCATAGCCCAGG	0.572000													81	225					0	0	1	0	0
RASL10B	91608	broad.mit.edu	37	17	34067503	34067503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34067503G>A	ENST00000268864.3	+	3	669	c.292G>A	c.(292-294)Gac>Aac	p.D98N		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	98	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGCTGCTTTGACAGCTTTGA	0.582000													33	57					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71977812	71977812	+	Silent	SNP	G	G	A	rs141274411		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71977812G>A	ENST00000266674.5	+	18	2333	c.2022G>A	c.(2020-2022)acG>acA	p.T674T	LGR5_ENST00000540815.2_Silent_p.T650T|LGR5_ENST00000536515.1_Silent_p.T602T			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	674						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						AATTTGAAACGAAAGCTCCAT	0.478000													42	168					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004535	75004535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:75004535G>A	ENST00000373359.2	-	1	544	c.352C>T	c.(352-354)Ctc>Ttc	p.L118F		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	118	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TACTCTCTGAGAAACTCCAGC	0.507000													12	19					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072667	17072667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17072667C>T	ENST00000359963.3	-	1	1033	c.774G>A	c.(772-774)acG>acA	p.T258T		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	258					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AAAGACGGGCCGTTGCTGGTG	0.507000													40	96					0	0	1	0	0
CEPT1	10390	broad.mit.edu	37	1	111724867	111724867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111724867C>T	ENST00000545121.1	+	6	981	c.773C>T	c.(772-774)aCc>aTc	p.T258I	CEPT1_ENST00000357172.4_Missense_Mutation_p.T258I|CEPT1_ENST00000467362.1_3'UTR	NM_001007794.1	NP_001007795.1	Q9Y6K0	CEPT1_HUMAN	choline/ethanolamine phosphotransferase 1	258						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	8		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	GTAGCAGGGACCATATTTTCC	0.338000													17	48					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77944600	77944600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77944600C>T	ENST00000393684.3	-	7	1310	c.919G>A	c.(919-921)Gac>Aac	p.D307N	ISM2_ENST00000429906.1_Missense_Mutation_p.D314N|ISM2_ENST00000342219.4_Missense_Mutation_p.D395N|ISM2_ENST00000493585.1_Silent_p.R279R|ISM2_ENST00000412904.1_Missense_Mutation_p.D314N			Q6H9L7	ISM2_HUMAN	isthmin 2	395						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						TCATGCATGTCCGTAGCATTG	0.602000													24	127					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80631636	80631636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:80631636G>A	ENST00000307624.3	-	12	1241	c.1213C>T	c.(1213-1215)Cgt>Tgt	p.R405C	ACOT12_ENST00000508234.1_5'UTR	NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	405	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		GACAAGAGACGATAAGCCAAA	0.348000													32	102					0	0	1	0	0
HDHD3	81932	broad.mit.edu	37	9	116136320	116136320	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116136320G>A	ENST00000238379.5	-	2	1212	c.315C>T	c.(313-315)ttC>ttT	p.F105F	HDHD3_ENST00000374180.3_Silent_p.F105F|HDHD3_ENST00000485934.1_5'UTR	NM_031219.2	NP_112496.1	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain containing 3	105							phosphoglycolate phosphatase activity|protein binding			large_intestine(2)|liver(1)	3						AGGGGTGGCTGAAGTCTTTAT	0.607000													32	115					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18807896	18807896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18807896C>T	ENST00000400664.1	+	1	473	c.421C>T	c.(421-423)Ccc>Tcc	p.P141S		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	141			P -> R (in dbSNP:rs2992755).			integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTTGCTGCCCCAGCCAGGA	0.642000													20	47					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48634378	48634378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48634378G>A	ENST00000435803.1	+	58	14737	c.14713G>A	c.(14713-14715)Gaa>Aaa	p.E4905K	ABCA13_ENST00000544596.1_Missense_Mutation_p.E635K	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4905	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGAGGTTCGGGAAGGCTGTGC	0.488000													43	97					0	0	1	0	0
NXPE2	120406	broad.mit.edu	37	11	114569186	114569186	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:114569186G>A	ENST00000375475.5	+	3	650	c.552G>A	c.(550-552)gaG>gaA	p.E184E	NXPE2_ENST00000389586.4_Silent_p.E184E					neurexophilin and PC-esterase domain family, member 2																		TGTTCTGGGAGGGCCAGGTTT	0.547000													8	36					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72324887	72324887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72324887G>A	ENST00000356056.5	-	3	1355	c.883C>T	c.(883-885)Cgt>Tgt	p.R295C	MYO9A_ENST00000424560.1_Missense_Mutation_p.R295C|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000564571.1_Missense_Mutation_p.R295C|MYO9A_ENST00000444904.1_Missense_Mutation_p.R295C|MYO9A_ENST00000566885.1_5'UTR|RP11-390D11.1_ENST00000568391.1_RNA	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	295	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTCCCAAAACGACTTGAATTG	0.333000													12	78					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999795	112999795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112999795C>T	ENST00000271277.6	+	6	1906	c.1681C>T	c.(1681-1683)Ccc>Tcc	p.P561S	CTTNBP2NL_ENST00000607039.1_3'UTR|RP4-671G15.3_ENST00000508462.1_RNA	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	561						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCCCTGAGCCCCCTGTCTCC	0.557000													29	89					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89949407	89949407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89949407C>T	ENST00000405460.2	+	20	4112	c.4016C>T	c.(4015-4017)aCt>aTt	p.T1339I		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1339					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCATTTGGGACTGTTAATCCA	0.448000													13	25					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71008381	71008381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71008381C>T	ENST00000354624.5	+	10	1600	c.1467C>T	c.(1465-1467)gcC>gcT	p.A489A	HKDC1_ENST00000395086.2_Silent_p.A489A|HKDC1_ENST00000488706.1_3'UTR	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	489					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						ACGTGCAGGCCAAGATGCGGG	0.667000													10	33					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656476	40656476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:40656476C>T	ENST00000406785.1	-	2	1134	c.945G>A	c.(943-945)agG>agA	p.R315R	SLC8A1_ENST00000542024.1_Silent_p.R315R|SLC8A1_ENST00000542756.1_Silent_p.R315R|SLC8A1_ENST00000332839.4_Silent_p.R315R|SLC8A1_ENST00000405901.3_Silent_p.R315R|SLC8A1_ENST00000403092.1_Silent_p.R315R|SLC8A1_ENST00000405269.1_Silent_p.R315R|SLC8A1_ENST00000402441.1_Silent_p.R315R|SLC8A1_ENST00000408028.2_Silent_p.R315R|SLC8A1_ENST00000406391.2_Silent_p.R315R			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	315					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CATCTTGGTCCCTCTCATCCA	0.408000													72	159					0	0	1	0	0
CYS1	192668	broad.mit.edu	37	2	10199021	10199021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:10199021C>T	ENST00000381813.4	-	3	623	c.436G>A	c.(436-438)Gag>Aag	p.E146K	CYS1_ENST00000477304.1_5'UTR	NM_001037160.2	NP_001032237.1	Q717R9	CYS1_HUMAN	cystin 1	146						cilium axoneme				large_intestine(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.166)|OV - Ovarian serous cystadenocarcinoma(76;0.227)		ATCAGCCCCTCTTCCGAGTGG	0.677000													8	5					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110478892	110478892	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110478892C>T	ENST00000378402.5	+	50	8603	c.8499C>T	c.(8497-8499)ttC>ttT	p.F2833F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2833					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCATTGGGTTCCCTGGATCAG	0.478000										HNSCC(38;0.096)			6	15					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36789956	36789956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36789956C>T	ENST00000361475.2	-	2	229	c.56G>A	c.(55-57)cGa>cAa	p.R19Q	TGM2_ENST00000536701.1_Missense_Mutation_p.R19Q|TGM2_ENST00000536724.1_Intron	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	19					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	GTGGTGGTCTCGGCCATTGGT	0.622000													38	94					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4391133	4391133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4391133G>A	ENST00000355530.2	+	12	1763	c.1483G>A	c.(1483-1485)Gac>Aac	p.D495N	SPNS3_ENST00000333476.2_Missense_Mutation_p.D368N	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	495					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GGACAGCAACGACCTGGAGAG	0.622000													59	68					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56086308	56086308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56086308C>T	ENST00000312711.1	+	1	526	c.526C>T	c.(526-528)Cat>Tat	p.H176Y		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					CGTCATTAGTCATTTCTACTG	0.358000													25	79					0	0	1	0	0
NCMAP	400746	broad.mit.edu	37	1	24921982	24921982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24921982G>A	ENST00000374392.2	+	2	127	c.61G>A	c.(61-63)Gga>Aga	p.G21R	NCMAP_ENST00000486262.1_3'UTR	NM_001010980.4	NP_001010980.1			noncompact myelin associated protein																		GACCACCAGGGGAGAAGACTT	0.473000													13	52					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12187389	12187389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12187389C>T	ENST00000439326.3	+	4	1629	c.1454C>T	c.(1453-1455)tCa>tTa	p.S485L	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	485					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						GTAAAGCCTTCATTTTTTCCA	0.448000													38	70					0	0	1	0	0
PYCR2	29920	broad.mit.edu	37	1	226108237	226108237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226108237G>A	ENST00000343818.6	-	7	1029	c.881C>T	c.(880-882)tCc>tTc	p.S294F	RP4-559A3.7_ENST00000432920.2_Intron|PYCR2_ENST00000478402.1_5'UTR	NM_013328.2	NP_037460.2	Q96C36	P5CR2_HUMAN	pyrroline-5-carboxylate reductase family, member 2	294					proline biosynthetic process	cytoplasm	binding|pyrroline-5-carboxylate reductase activity			kidney(1)|lung(3)	4	Breast(184;0.197)				L-Proline(DB00172)|NADH(DB00157)	GACTGTGGGGGATTCCAGCTT	0.572000													50	108					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69817442	69817442	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69817442G>A	ENST00000251566.4	-	1	67	c.37C>T	c.(37-39)Ctg>Ttg	p.L13L		NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	13						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AAGAGCTGCAGGAGCAGAAAT	0.468000													13	44					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86954832	86954832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86954832G>A	ENST00000234701.3	+	9	1687	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	CLCA1_ENST00000394711.1_Missense_Mutation_p.E446K			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	446	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TCAAGAACTAGAGGAGCTGTC	0.527000													7	44					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47225277	47225277	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47225277G>A	ENST00000391910.3	-	16	2529	c.2079C>T	c.(2077-2079)gcC>gcT	p.A693A	STRN4_ENST00000263280.6_Silent_p.A686A|STRN4_ENST00000539396.1_Silent_p.A567A			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	686						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		TGGGGTCCACGGCTAGGCAGG	0.632000													34	70					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12666919	12666919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12666919C>T	ENST00000425538.1	+	14	3119	c.2919C>T	c.(2917-2919)ctC>ctT	p.L973L	RP11-1090M7.1_ENST00000584772.1_RNA|MYOCD_ENST00000343344.4_Silent_p.L925L	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	925					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCACTGATCTCAATTTGAATT	0.522000													14	31					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15978098	15978098	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:15978098G>A	ENST00000262101.5	-	9	1172	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	MSR1_ENST00000445506.2_Nonsense_Mutation_p.R369*|MSR1_ENST00000355282.2_Intron|MSR1_ENST00000350896.3_Intron			P21757	MSRE_HUMAN	macrophage scavenger receptor 1	351	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity	p.R351R(1)		haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCGACCAGTCGAACTTTCGTA	0.453000													22	55					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76739023	76739023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76739023C>T	ENST00000287239.4	+	10	2646	c.2157C>T	c.(2155-2157)taC>taT	p.Y719Y	KAT6B_ENST00000372714.1_Silent_p.Y427Y|KAT6B_ENST00000490365.1_3'UTR|KAT6B_ENST00000372725.1_Silent_p.Y427Y|KAT6B_ENST00000372711.1_Silent_p.Y536Y|KAT6B_ENST00000372724.1_Silent_p.Y427Y	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	719	Catalytic.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										GTGGCCGGTACCCTTCTGTGA	0.388000													20	56					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79382659	79382659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79382659C>T	ENST00000419573.3	-	1	456	c.182G>A	c.(181-183)cGg>cAg	p.R61Q	RASGRF1_ENST00000558480.2_Missense_Mutation_p.R61Q	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	61	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CCCCGAGGGCCGCGAGCTCGA	0.637000													49	52					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105167206	105167206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105167206G>A	ENST00000428173.2	+	18	3013	c.2710G>A	c.(2710-2712)Gat>Aat	p.D904N	NRK_ENST00000243300.9_Missense_Mutation_p.D903N			Q7Z2Y5	NRK_HUMAN	Nik related kinase	903							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						CTTCCGGAATGATTGGTTAAC	0.428000										HNSCC(51;0.14)			24	24					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175463	143175463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143175463G>A	ENST00000408916.1	+	1	498	c.498G>A	c.(496-498)ggG>ggA	p.G166G	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	166					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					AATTTTCTGGGAACATGACCT	0.383000													17	49					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35587930	35587930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35587930C>T	ENST00000542713.1	-	4	529	c.372G>A	c.(370-372)tcG>tcA	p.S124S	FKBP5_ENST00000540787.1_Intron|FKBP5_ENST00000357266.4_Silent_p.S124S|FKBP5_ENST00000536438.1_Silent_p.S124S|FKBP5_ENST00000539068.1_Silent_p.S124S	NM_001145777.1	NP_001139249.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	124	PPIase FKBP-type 1.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						GAGTTGCATTCGAGGGAATTT	0.453000													33	83					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233410387	233410387	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233410387C>A	ENST00000389494.3	+	12	1536	c.1515C>A	c.(1513-1515)ttC>ttA	p.F505L	CHRNG_ENST00000389492.3_Missense_Mutation_p.F453L	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	505					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CCCTGCCATTCCCTGGAGATC	0.607000													8	80					0.00829132	0.00829501	1	1	0
PABPC4	8761	broad.mit.edu	37	1	40027429	40027429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40027429G>A	ENST00000372857.3	-	15	2668	c.1876C>T	c.(1876-1878)Cat>Tat	p.H626Y	PABPC4_ENST00000372862.3_Missense_Mutation_p.H597Y|PABPC4_ENST00000372856.3_Missense_Mutation_p.H613Y|PABPC4_ENST00000372858.3_Missense_Mutation_p.H642Y	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	626	PABC.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTGGCATGATGAGCCTGTAGA	0.502000													19	59					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124281801	124281801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124281801G>A	ENST00000360013.3	+	34	5168	c.5041G>A	c.(5041-5043)Gag>Aag	p.E1681K	KALRN_ENST00000393496.1_Missense_Mutation_p.E54K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1681	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.E1681*(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCGGCCCAGCGAGCGGCCTGG	0.657000													12	36					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2769796	2769796	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:2769796C>T	ENST00000320876.6	+	38	5162	c.4824C>T	c.(4822-4824)atC>atT	p.I1608I	SMCHD1_ENST00000261598.8_Silent_p.I1608I|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1608					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						AACCATATATCCTACCGTTCA	0.363000													5	10					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413721	72413721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72413721C>T	ENST00000395270.1	+	14	3435	c.2394C>T	c.(2392-2394)gtC>gtT	p.V798V	POM121_ENST00000358357.3_Silent_p.V798V|POM121_ENST00000257622.4_Silent_p.V798V|POM121_ENST00000446813.1_Silent_p.V798V|POM121_ENST00000434423.2_Silent_p.V1063V	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1063	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CCACTGCTGTCTTCTTCGGTG	0.662000													11	60					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154271117	154271117	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154271117G>A	ENST00000285873.7	-	26	4021	c.3946C>T	c.(3946-3948)Cag>Tag	p.Q1316*		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	1316					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCTAACTGCTGGCTTGGCTCA	0.517000													56	85					0	0	1	0	0
SLC1A7	6512	broad.mit.edu	37	1	53556411	53556411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53556411G>A	ENST00000371494.4	-	8	1226	c.1099C>T	c.(1099-1101)Cgc>Tgc	p.R367C	SLC1A7_ENST00000488036.1_5'UTR	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	367						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	AGCACGAAGCGAGCGATGCGC	0.622000													15	26					0	0	1	0	0
SDSL	113675	broad.mit.edu	37	12	113875773	113875773	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113875773C>T	ENST00000403593.4	+	8	1141	c.879C>T	c.(877-879)gcC>gcT	p.A293A	SDSL_ENST00000345635.4_Silent_p.A293A			Q96GA7	SDSL_HUMAN	serine dehydratase-like	293					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	GGCTCCAGGCCGAGGGCTGCC	0.607000													70	253					0	0	1	0	0
OLIG3	167826	broad.mit.edu	37	6	137815305	137815305	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:137815305C>T	ENST00000367734.2	-	1	226	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	1					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		AATCAGAATTCATTTTATTAC	0.493000													28	39					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178564819	178564819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178564819G>A	ENST00000251582.7	-	12	2003	c.1902C>T	c.(1900-1902)ttC>ttT	p.F634F		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	634	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CGCCGTGCTCGAAGTACAGGT	0.692000													3	8					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6467622	6467622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6467622C>T	ENST00000381480.2	-	23	2411	c.2299G>A	c.(2299-2301)Gaa>Aaa	p.E767K	DENND1C_ENST00000543576.1_Missense_Mutation_p.E723K	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	767						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GCTCCTGGTTCCTCCCGTGGC	0.622000													19	34					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117662894	117662894	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117662894G>A	ENST00000317775.6	-	25	4438	c.3753C>T	c.(3751-3753)ctC>ctT	p.L1251L	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.L1285L	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1251					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTGGTCCAACGAGGATGCAGG	0.572000													49	121					0	0	1	0	0
SCRN1	9805	broad.mit.edu	37	7	29980386	29980386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:29980386C>T	ENST00000426154.1	-	5	827	c.651G>A	c.(649-651)gaG>gaA	p.E217E	SCRN1_ENST00000416113.2_Intron|SCRN1_ENST00000242059.5_Silent_p.E217E|SCRN1_ENST00000409497.1_Silent_p.E217E	NM_001145513.1	NP_001138985.1	Q12765	SCRN1_HUMAN	secernin 1	217					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(2)|prostate(2)|skin(2)	25						TGAACTCGCCCTCTCCCGTCC	0.493000													56	156					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32017145	32017145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32017145G>A	ENST00000375244.3	-	28	9860	c.9659C>T	c.(9658-9660)aCc>aTc	p.T3220I	TNXB_ENST00000375247.2_Missense_Mutation_p.T3218I			P22105	TENX_HUMAN	tenascin XB	3265	Fibronectin type-III 24.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCCCCCCACGGTGACCTCGCT	0.687000													23	38					0	0	1	0	0
HBZ	3050	broad.mit.edu	37	16	202971	202971	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:202971G>A	ENST00000252951.2	+	1	286	c.63G>A	c.(61-63)caG>caA	p.Q21Q		NM_005332.2	NP_005323.1	P02008	HBAZ_HUMAN	hemoglobin, zeta	21						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;4.28e-07)|all_epithelial(16;2.09e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				TCTCCACGCAGGCCGACACCA	0.627000													5	29					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149456979	149456979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149456979G>A	ENST00000286301.3	-	6	1040	c.749C>T	c.(748-750)tCt>tTt	p.S250F	CSF1R_ENST00000543093.1_Missense_Mutation_p.S250F	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	250	Ig-like C2-type 3.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	ATGAAAGTCAGATTGTTGAGG	0.463000													46	130					0	0	1	0	0
ABHD2	11057	broad.mit.edu	37	15	89738534	89738534	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89738534C>T	ENST00000352732.5	+	11	1678	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F	ABHD2_ENST00000565973.1_Silent_p.F386F|ABHD2_ENST00000355100.3_Silent_p.F386F	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	386						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					CTGTGCTGTTCCCCGAGCCCC	0.572000													22	80					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263426	140263426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140263426C>T	ENST00000289272.2	+	1	1573	c.1573C>T	c.(1573-1575)Cac>Tac	p.H525Y	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.H525Y|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGTTGGACCACGAGGAGCT	0.682000													18	193					0	0	1	0	0
ACSM3	6296	broad.mit.edu	37	16	20803324	20803324	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20803324G>A	ENST00000289416.5	+	11	1802	c.1326_splice	c.e11-1	p.D443_splice	ERI2_ENST00000300005.3_Intron|ACSM3_ENST00000567387.1_3'UTR|ACSM3_ENST00000450120.2_Splice_Site_p.D435_splice	NM_005622.3	NP_005613.2	Q53FZ2	ACSM3_HUMAN	acyl-CoA synthetase medium-chain family member 3	443					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	21						TGTTTTGCAGGATAATCCTTC	0.368000													38	66					0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19378024	19378024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:19378024C>T	ENST00000550708.1	+	1	503	c.431C>T	c.(430-432)cCc>cTc	p.P144L		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCTGCCGTCCCTTGCTCTAT	0.448000													41	121					0	0	1	0	0
ALKBH4	54784	broad.mit.edu	37	7	102097929	102097929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:102097929G>A	ENST00000292566.3	-	3	860	c.821C>T	c.(820-822)tCg>tTg	p.S274L		NM_017621.3	NP_060091.1	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4 (E. coli)	274						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(5)|skin(2)	8						AAACTCAGCCGACAGCTCCCG	0.667000													14	37					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12125274	12125274	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:12125274C>T	ENST00000379388.2	+	4	5578	c.5246C>T	c.(5245-5247)tCc>tTc	p.S1749F		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1749					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGATGCTTTCCCCAGCAAAT	0.433000													14	85					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16757789	16757789	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16757789C>T	ENST00000375577.1	-	2	417	c.78G>A	c.(76-78)agG>agA	p.R26R	SPATA21_ENST00000466212.1_5'UTR|SPATA21_ENST00000335496.1_Intron|SPATA21_ENST00000540400.1_Intron			Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	27							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TTATGGTGATCCTCAGGCCAG	0.567000													13	30					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123687318	123687318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:123687318C>T	ENST00000334268.4	-	20	1600	c.1283G>A	c.(1282-1284)cGa>cAa	p.R428Q	TRDN_ENST00000398178.3_Missense_Mutation_p.R428Q			Q13061	TRDN_HUMAN	triadin	428					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		CTCTTTGGCTCGTTCAGTTTC	0.308000													8	14					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046475	73046475	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73046475G>A	ENST00000604411.1	+	0	34436				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GTAGGGTTTAGGGTTCTCATC	0.423000													72	54					0	0	1	0	0
SPTLC1	10558	broad.mit.edu	37	9	94809925	94809925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:94809925G>A	ENST00000262554.2	-	10	959	c.954C>T	c.(952-954)tgC>tgT	p.C318C		NM_006415.2	NP_006406.1	O15269	SPTC1_HUMAN	serine palmitoyltransferase, long chain base subunit 1	318						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACCTGCCACAGCAGAAACCTC	0.393000													7	32					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168112740	168112740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168112740C>T	ENST00000519560.1	-	31	3926	c.3507G>A	c.(3505-3507)gtG>gtA	p.V1169V	SLIT3_ENST00000332966.8_Silent_p.V1176V|SLIT3_ENST00000404867.3_Silent_p.V1169V	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1169	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGCCAGTTCCACGTAGGAGT	0.642000													22	58					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41648155	41648155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41648155C>T	ENST00000400454.1	-	11	2702	c.2225G>A	c.(2224-2226)cGa>cAa	p.R742Q		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	742	Ig-like C2-type 8.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AACTTGGATTCGGCCATTTAG	0.512000													27	39					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142574244	142574244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142574244C>T	ENST00000359396.3	-	6	924	c.679G>A	c.(679-681)Gac>Aac	p.D227N	RP11-114L10.2_ENST00000438839.1_RNA	NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	227					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					TGCAGGTGGTCCCCATGTCTG	0.572000													25	48					0	0	1	0	0
IL20RB	53833	broad.mit.edu	37	3	136708326	136708326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:136708326C>T	ENST00000329582.4	+	4	699	c.450C>T	c.(448-450)ttC>ttT	p.F150F	IL20RB_ENST00000309741.5_Silent_p.F103F|IL20RB_ENST00000484501.1_3'UTR	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	150	Fibronectin type-III 2.					integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						AAGATGGCTTCCACCTGGTTA	0.582000													17	58					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58129186	58129186	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58129186C>T	ENST00000257897.3	-	2	270	c.185G>A	c.(184-186)tGg>tAg	p.W62*	AGAP2_ENST00000547588.1_Nonsense_Mutation_p.W398*	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	398					axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						GCTCAAAGTCCATTCCTGGCT	0.592000													3	24					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038981	75038981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75038981G>A	ENST00000326665.5	-	14	2631	c.2413C>T	c.(2413-2415)Cat>Tat	p.H805Y	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	805	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGAGCCTCATGAACAGCTCCT	0.537000													47	123					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56712110	56712110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56712110G>A	ENST00000425394.2	-	25	3861	c.3485C>T	c.(3484-3486)tCt>tTt	p.S1162F	PAN2_ENST00000257931.5_Missense_Mutation_p.S1161F|PAN2_ENST00000440411.3_Missense_Mutation_p.S1158F|PAN2_ENST00000548043.1_Missense_Mutation_p.S1162F|PAN2_ENST00000549090.1_5'UTR	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	1162					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CTTGTGGAAAGACTCAGGCTC	0.512000													33	132					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50560661	50560661	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50560661G>A	ENST00000380984.4	-	10	1049	c.987C>T	c.(985-987)tgC>tgT	p.C329C	DDC_ENST00000431062.1_Intron|DDC_ENST00000357936.5_Intron|DDC_ENST00000426377.1_Intron|DDC_ENST00000444124.2_Intron	NM_001242890.1	NP_001229819.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CACTGACTAAGCAGGTTTTCT	0.557000													10	17					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38917344	38917344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38917344C>T	ENST00000359357.3	+	79	11849	c.11595C>T	c.(11593-11595)atC>atT	p.I3865I	DNAH8_ENST00000441566.1_Silent_p.I3829I|DNAH8_ENST00000449981.2_Silent_p.I4082I|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTTTACTTATCAGGTGAGAAC	0.363000													17	86					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38106446	38106446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38106446C>T	ENST00000406386.3	+	4	382	c.127C>T	c.(127-129)Cct>Tct	p.P43S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	43					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GCTCAGGAGCCCTTCAGGTGC	0.687000													14	26					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72338847	72338847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72338847G>A	ENST00000389916.4	+	4	448	c.310G>A	c.(310-312)Ggc>Agc	p.G104S		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	104	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CTTTGCCTATGGCCCCACAGG	0.592000													25	55					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605214	140605214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140605214C>T	ENST00000239449.4	+	1	2137	c.2137C>T	c.(2137-2139)Ctg>Ttg	p.L713L	PCDHB14_ENST00000515856.2_Silent_p.L560L	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		713					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGGTGCGGCTGTGCAGGAG	0.692000													46	245					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58240849	58240849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58240849G>A	ENST00000377918.3	+	3	2705	c.2679G>A	c.(2677-2679)ggG>ggA	p.G893G		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	893					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GTGGGCACGGGGACAGTGATC	0.448000													15	71					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41725472	41725472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41725472G>A	ENST00000400454.1	-	5	1331	c.854C>T	c.(853-855)cCc>cTc	p.P285L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	285	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGAGTCCGAGGGGCGAATGTT	0.537000													29	94					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95088716	95088716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95088716C>T	ENST00000553947.1	+	7	1919	c.1031C>T	c.(1030-1032)tCg>tTg	p.S344L	SERPINA3_ENST00000467132.1_Missense_Mutation_p.S319L|SERPINA3_ENST00000393080.4_Missense_Mutation_p.S319L|SERPINA3_ENST00000556388.1_3'UTR|SERPINA3_ENST00000482740.1_Missense_Mutation_p.S101L|SERPINA3_ENST00000393078.3_Missense_Mutation_p.S319L			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	319					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity	p.S319L(1)		NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TTTTCCATCTCGAGGGACTAT	0.498000													27	105					0	0	1	0	0
C21orf128	150147	broad.mit.edu	37	21	43524025	43524025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43524025G>A	ENST00000329015.2	-	2	359	c.208C>T	c.(208-210)Ccc>Tcc	p.P70S	UMODL1_ENST00000400427.1_Silent_p.G377G|UMODL1_ENST00000408989.2_Silent_p.G449G|UMODL1_ENST00000400424.1_Silent_p.G377G|UMODL1_ENST00000408910.2_Silent_p.G449G					chromosome 21 open reading frame 128											lung(4)	4						ACCGAAGTGGGAAGCTGAGAA	0.567000													40	100					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87912231	87912231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87912231G>A	ENST00000380079.4	-	3	810	c.709C>T	c.(709-711)Cgt>Tgt	p.R237C	AC003991.3_ENST00000595121.1_RNA|STEAP4_ENST00000414498.1_Missense_Mutation_p.R237C|AC003991.3_ENST00000434733.1_RNA|AC003991.3_ENST00000600908.1_RNA|AC003991.3_ENST00000447758.1_RNA|STEAP4_ENST00000301959.5_Intron	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	237					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					ATAGCCATACGAAATGTATTA	0.363000													31	99					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093066	30093066	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30093066C>T	ENST00000567636.1	+	0	1441					NR_003558.1																						TGGACCACCTCCAGGAGCTCC	0.582000													5	11					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207107939	207107939	+	Missense_Mutation	SNP	C	C	T	rs141320420	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207107939C>T	ENST00000356495.4	-	6	1714	c.1531G>A	c.(1531-1533)Gaa>Aaa	p.E511K		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	511	Ig-like V-type 5.					extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTGGGGCCTTCGTCTTGGCTG	0.577000													46	88					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54919034	54919034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54919034G>A	ENST00000545554.1	+	32	6368	c.6368G>A	c.(6367-6369)gGa>gAa	p.G2123E	UNC13C_ENST00000537900.1_Missense_Mutation_p.G2121E|UNC13C_ENST00000260323.11_Missense_Mutation_p.G2123E|UNC13C_ENST00000539562.2_Missense_Mutation_p.G44E			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2123	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.G2123E(2)		breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGCATTCTCGGAAAGGAAAAT	0.373000													8	35					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97170471	97170471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97170471G>A	ENST00000371247.2	-	10	1063	c.874C>T	c.(874-876)Cca>Tca	p.P292S	SORBS1_ENST00000277982.5_Missense_Mutation_p.P292S|SORBS1_ENST00000306402.6_Missense_Mutation_p.P169S|SORBS1_ENST00000361941.3_Missense_Mutation_p.P292S|SORBS1_ENST00000607232.1_Missense_Mutation_p.P137S|SORBS1_ENST00000371241.1_Missense_Mutation_p.P128S|SORBS1_ENST00000347291.4_Missense_Mutation_p.P160S|SORBS1_ENST00000354106.3_Missense_Mutation_p.P283S|SORBS1_ENST00000371245.3_Missense_Mutation_p.P223S|SORBS1_ENST00000371246.2_Missense_Mutation_p.P292S|SORBS1_ENST00000371227.4_Missense_Mutation_p.P292S|SORBS1_ENST00000371239.1_Missense_Mutation_p.P137S|SORBS1_ENST00000353505.5_Missense_Mutation_p.P223S|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000371249.2_Missense_Mutation_p.P260S|SORBS1_ENST00000393949.1_Missense_Mutation_p.P283S			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	292				PSVS -> SSEC (in Ref. 1; AAD27647 and 3; AAF22175).	focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CTAACTGATGGAAAGGCTTGG	0.428000													19	71					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84605985	84605985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84605985C>T	ENST00000344803.2	+	4	647	c.600C>T	c.(598-600)ctC>ctT	p.L200L		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CCTTAATTCTCTCACCTGACC	0.552000													44	75					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169698458	169698458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169698458G>A	ENST00000333360.7	-	7	1098	c.959C>T	c.(958-960)tCc>tTc	p.S320F	SELE_ENST00000367780.4_Missense_Mutation_p.S258F|SELE_ENST00000367781.4_Missense_Mutation_p.S320F|SELE_ENST00000367779.4_Missense_Mutation_p.S320F|SELE_ENST00000367782.4_Missense_Mutation_p.S320F|SELE_ENST00000367777.1_Missense_Mutation_p.S320F|SELE_ENST00000367775.1_Missense_Mutation_p.S258F|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367776.1_Missense_Mutation_p.S320F|SELE_ENST00000367774.1_Missense_Mutation_p.S320F	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	320	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TCCAGCAGGGGAATGGCTGCA	0.522000													10	37					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24529224	24529224	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24529224C>T	ENST00000342740.5	+	23	2068	c.1914C>T	c.(1912-1914)tcC>tcT	p.S638S	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	638										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GCGACATCTCCCAAGCCTATC	0.662000													32	129					0	0	1	0	0
VSX2	338917	broad.mit.edu	37	14	74711967	74711967	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74711967G>A	ENST00000261980.2	+	3	645	c.555G>A	c.(553-555)acG>acA	p.T185T		NM_182894.2	NP_878314.1	P58304	VSX2_HUMAN	visual system homeobox 2	185					multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00154)		CCATGAAAACGGAGCTGCCGG	0.577000													15	55					0	0	1	0	0
AMER2	219287	broad.mit.edu	37	13	25744230	25744230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25744230C>T	ENST00000357816.2	-	3	1646	c.1171G>A	c.(1171-1173)Gag>Aag	p.E391K	AMER2_ENST00000381853.3_Missense_Mutation_p.E391K|AMER2_ENST00000515384.1_Missense_Mutation_p.E510K					APC membrane recruitment protein 2																		TGCTCCTTCTCCGGGTGCTTG	0.652000													24	86					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685705	248685705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248685705G>A	ENST00000343414.4	+	1	790	c.758G>A	c.(757-759)gGg>gAg	p.G253E		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTTTCTATGGGACCATCATA	0.438000													14	96					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28120072	28120072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28120072C>T	ENST00000330236.6	+	5	869	c.685C>T	c.(685-687)Ctt>Ttt	p.L229F	ZKSCAN8_ENST00000457389.2_Missense_Mutation_p.L229F	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		GGCTGTGTCCCTTATTCGAGA	0.453000													36	147					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54556509	54556509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54556509G>A	ENST00000545554.1	+	8	3592	c.3592G>A	c.(3592-3594)Gaa>Aaa	p.E1198K	UNC13C_ENST00000537900.1_Missense_Mutation_p.E1196K|UNC13C_ENST00000260323.11_Missense_Mutation_p.E1198K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1198					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GATTTCTAAAGAAGATTTTGT	0.373000													6	10					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28877480	28877480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28877480C>T	ENST00000282397.4	-	30	4092	c.3841G>A	c.(3841-3843)Gag>Aag	p.E1281K	FLT1_ENST00000543394.1_Missense_Mutation_p.E304K|FLT1_ENST00000540678.1_Missense_Mutation_p.E499K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1281					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGCCCCGACTCCTTACTTTTA	0.443000													18	39					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1243834	1243834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1243834G>A	ENST00000324642.3	+	9	1419	c.1296G>A	c.(1294-1296)gtG>gtA	p.V432V	SLC6A18_ENST00000296821.4_Intron	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	432					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.V434fs*11(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGCTGGACGTGGGGGTCCTGC	0.652000													8	52					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19713778	19713778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:19713778G>A	ENST00000284885.3	-	13	1549	c.1516C>T	c.(1516-1518)Ctt>Ttt	p.L506F		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	506					proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity	p.L506I(1)		NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TCTGGATAAAGACTCCCATTG	0.383000													37	101					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155408848	155408848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155408848G>A	ENST00000368346.3	-	5	5737	c.5098C>T	c.(5098-5100)Ccc>Tcc	p.P1700S	ASH1L_ENST00000392403.3_Missense_Mutation_p.P1700S			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1700	Ser-rich.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTTCGAGAGGGAACTCCGTTT	0.413000													15	58					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38646359	38646359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38646359G>A	ENST00000413689.1	-	11	1572	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F	SCN5A_ENST00000423572.2_Missense_Mutation_p.S460F|SCN5A_ENST00000425664.1_Missense_Mutation_p.S460F|SCN5A_ENST00000333535.4_Missense_Mutation_p.S460F|SCN5A_ENST00000451551.2_Missense_Mutation_p.S460F|SCN5A_ENST00000455624.2_Missense_Mutation_p.S460F|SCN5A_ENST00000449557.2_Missense_Mutation_p.S460F|SCN5A_ENST00000450102.2_Missense_Mutation_p.S460F|SCN5A_ENST00000443581.1_Missense_Mutation_p.S460F|SCN5A_ENST00000414099.2_Missense_Mutation_p.S460F	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	460					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CATCTCCAAGGAGCTACGGGA	0.547000													9	22					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10104320	10104320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10104320C>T	ENST00000264828.3	-	18	1755	c.1670G>A	c.(1669-1671)gGg>gAg	p.G557E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	557	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			ACCAGGCAGCCCAGGGAGGCC	0.592000													18	58					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9943555	9943555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9943555C>T	ENST00000506583.1	-	8	926	c.709G>A	c.(709-711)Gag>Aag	p.E237K	SLC2A9_ENST00000309065.3_Missense_Mutation_p.E237K|SLC2A9_ENST00000264784.3_Missense_Mutation_p.E266K			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	266					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						GCTCTTGCCTCGTTGTGCTTC	0.582000													16	28					0	0	1	0	0
BSPRY	54836	broad.mit.edu	37	9	116132056	116132056	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116132056C>T	ENST00000374183.4	+	6	882	c.843C>T	c.(841-843)ttC>ttT	p.F281F	BSPRY_ENST00000462085.1_3'UTR	NM_017688.2	NP_060158.2	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	281	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						CCACCTCCTTCCAGAATGGGC	0.597000													22	45					0	0	1	0	0
RBMX2	51634	broad.mit.edu	37	X	129546525	129546525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:129546525C>T	ENST00000305536.6	+	6	736	c.672C>T	c.(670-672)ctC>ctT	p.L224L		NM_016024.2	NP_057108.2	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	224	Lys-rich.						nucleotide binding|RNA binding			breast(4)|endometrium(2)|large_intestine(1)|liver(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	19						GGCAGAAGCTCCCCAAATCCA	0.557000													37	14					0	0	1	0	0
DCAF5	8816	broad.mit.edu	37	14	69558597	69558597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:69558597G>A	ENST00000341516.5	-	6	820	c.673C>T	c.(673-675)Ctg>Ttg	p.L225L	DCAF5_ENST00000556847.1_Silent_p.L143L|DCAF5_ENST00000553293.1_5'UTR|DCAF5_ENST00000554215.1_Silent_p.L143L|DCAF5_ENST00000557386.1_Silent_p.L224L|DCAF5_ENST00000389997.6_Silent_p.L225L	NM_003861.2	NP_003852.1	Q96JK2	DCAF5_HUMAN	DDB1 and CUL4 associated factor 5	225						CUL4 RING ubiquitin ligase complex				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|upper_aerodigestive_tract(2)	29						CCATAGCGCAGGAGAGAACTG	0.542000													6	19					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128856489	128856489	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128856489G>A	ENST00000310343.9	-	13	1330	c.1331C>T	c.(1330-1332)tCc>tTc	p.S444F	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.S95F|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.S95F|ARHGAP32_ENST00000524655.1_Missense_Mutation_p.S370F	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	444	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CTTACATAGGGAACCCACAGA	0.468000													23	87					0	0	1	0	0
IFNA14	3448	broad.mit.edu	37	9	21239413	21239413	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21239413G>A	ENST00000380222.2	-	1	565	c.522C>T	c.(520-522)tcC>tcT	p.S174S		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	174					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AAAAAGAGAGGGATCTCATGA	0.388000													99	357					0	0	1	0	0
FUT4	2526	broad.mit.edu	37	11	94277911	94277911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94277911C>T	ENST00000358752.2	+	1	895	c.612C>T	c.(610-612)gcC>gcT	p.A204A		NM_002033.3	NP_002024.1	P22083	FUT4_HUMAN	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	204					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCGATAGCGCCCCGAGGCCGC	0.746000													3	8					0	0	1	0	0
SLC16A3	9123	broad.mit.edu	37	17	80195756	80195756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80195756G>A	ENST00000581287.1	+	3	3432	c.1110G>A	c.(1108-1110)ggG>ggA	p.G370G	SLC16A3_ENST00000392341.1_Silent_p.G370G|SLC16A3_ENST00000582743.1_Silent_p.G370G|SLC16A3_ENST00000392339.1_Silent_p.G370G	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	370					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	TGCTCGTCGGGCCCCCTTCGG	0.701000													14	25					0	0	1	0	0
RHBDL2	54933	broad.mit.edu	37	1	39381281	39381281	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:39381281C>A	ENST00000289248.2	-	3	1356	c.348G>T	c.(346-348)aaG>aaT	p.K116N	RHBDL2_ENST00000540558.1_Missense_Mutation_p.K116N|RP5-864K19.4_ENST00000433671.2_RNA|RHBDL2_ENST00000372985.3_Missense_Mutation_p.K196N|RHBDL2_ENST00000538156.1_Missense_Mutation_p.K183N|RHBDL2_ENST00000372990.1_Missense_Mutation_p.K116N			Q9NX52	RHBL2_HUMAN	rhomboid, veinlet-like 2 (Drosophila)	116					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	8	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CTTCCTCCCTCTTCTCAGGAC	0.453000													21	83					1.22574e-08	1.22991e-08	1	1	0
MIPOL1	145282	broad.mit.edu	37	14	37969339	37969339	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:37969339C>T	ENST00000327441.7	+	13	1724	c.1258C>T	c.(1258-1260)Caa>Taa	p.Q420*	MIPOL1_ENST00000537471.1_Nonsense_Mutation_p.Q420*|MIPOL1_ENST00000539062.2_Nonsense_Mutation_p.Q389*|MIPOL1_ENST00000545536.1_Nonsense_Mutation_p.Q389*|MIPOL1_ENST00000556451.1_Nonsense_Mutation_p.Q389*|MIPOL1_ENST00000396294.2_Nonsense_Mutation_p.Q420*|MIPOL1_ENST00000536774.1_Nonsense_Mutation_p.Q239*	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	420										breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		TGAAAAAGTTCAAAAGTAAGT	0.358000													8	39					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47422304	47422304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47422304C>T	ENST00000361866.3	+	32	2353	c.2239C>T	c.(2239-2241)Ccc>Tcc	p.P747S	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	747	C-terminal globular domain.|VWFA 2.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GCTCTGCAGCCCCGGCATCCA	0.701000													4	7					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21329770	21329770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21329770C>T	ENST00000256958.2	+	5	516	c.420C>T	c.(418-420)tcC>tcT	p.S140S		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	140					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CGACCTTATCCACTTGTTTAA	0.289000													23	94					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51516198	51516198	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:51516198C>T	ENST00000328188.1	+	1	917	c.917C>T	c.(916-918)tCa>tTa	p.S306L		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						AAGGACATTTCAGGTGACAAA	0.358000													21	39					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36563655	36563655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36563655C>T	ENST00000397799.1	-	4	1851	c.1627G>A	c.(1627-1629)Ggc>Agc	p.G543S	COL8A2_ENST00000481785.1_Missense_Mutation_p.G478S|COL8A2_ENST00000303143.4_Missense_Mutation_p.G543S			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	543	Nonhelical region (NC1).				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGGTGCAAGCCTGCGATGCCA	0.726000													8	20					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143921	55143921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55143921C>T	ENST00000396331.1	+	7	1025	c.668C>T	c.(667-669)tCt>tTt	p.S223F	LILRB1_ENST00000448689.1_Missense_Mutation_p.S223F|LILRB1_ENST00000434867.2_Missense_Mutation_p.S223F|LILRB1_ENST00000396332.4_Missense_Mutation_p.S223F|LILRB1_ENST00000427581.2_Missense_Mutation_p.S259F|LILRB1_ENST00000324602.7_Missense_Mutation_p.S223F|LILRB1_ENST00000418536.2_Missense_Mutation_p.S223F|LILRB1_ENST00000396317.1_Missense_Mutation_p.S223F|LILRB1_ENST00000396321.2_Missense_Mutation_p.S223F|LILRB1_ENST00000396315.1_Missense_Mutation_p.S223F|LILRB1_ENST00000396327.3_Missense_Mutation_p.S223F	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	223	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCAGGTGTTTCTAAGAAGCCA	0.557000										HNSCC(37;0.09)			34	80					0	0	1	0	0
BMP4	652	broad.mit.edu	37	14	54418878	54418878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:54418878C>T	ENST00000245451.4	-	3	456	c.63G>A	c.(61-63)gcG>gcA	p.A21A	BMP4_ENST00000558984.1_Silent_p.A21A|BMP4_ENST00000559087.1_Silent_p.A21A|BMP4_ENST00000417573.1_Silent_p.A21A	NM_001202.3	NP_001193.2	P12644	BMP4_HUMAN	bone morphogenetic protein 4	21					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(3)|urinary_tract(1)	19						TAGCATGGCTCGCGCCTCCTA	0.567000													23	64					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36093535	36093535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36093535C>T	ENST00000303965.4	-	28	4882	c.4393G>A	c.(4393-4395)Gat>Aat	p.D1465N		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1465	PH 5.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGAAACCCATCTCGTAAAACA	0.328000													23	69					0	0	1	0	0
TMEM214	54867	broad.mit.edu	37	2	27260509	27260509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27260509C>T	ENST00000238788.9	+	9	1153	c.1091C>T	c.(1090-1092)aCc>aTc	p.T364I	TMEM214_ENST00000404032.3_Missense_Mutation_p.T319I	NM_017727.4	NP_060197.4	Q6NUQ4	TM214_HUMAN	transmembrane protein 214	364						integral to membrane	protein binding			kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						ACCCTGCATACCTACTTCCCT	0.577000													49	113					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57828873	57828873	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57828873C>T	ENST00000309668.2	+	1	331	c.204C>T	c.(202-204)tcC>tcT	p.S68S	INHBC_ENST00000550133.1_Silent_p.S68S	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	68					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						GCCCTGTGTCCAGAGCTGCTT	0.572000													11	69					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8492966	8492966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8492966G>A	ENST00000381196.4	-	24	2906	c.2363C>T	c.(2362-2364)tCt>tTt	p.S788F	PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.S788F|PTPRD_ENST00000360074.4_Missense_Mutation_p.S775F|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.S766F|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.S788F|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000397606.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	788	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTGGAGCCCAGAAATGATCAT	0.493000										TSP Lung(15;0.13)			8	77					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468488	56468488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56468488C>T	ENST00000312153.1	+	1	625	c.625C>T	c.(625-627)Ccc>Tcc	p.P209S		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						TGTCATCTGCCCCGCAGTGCT	0.527000													13	215					0	0	1	0	0
FMO4	2329	broad.mit.edu	37	1	171310668	171310668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171310668G>A	ENST00000367749.3	+	10	1697	c.1367G>A	c.(1366-1368)aGa>aAa	p.R456K		NM_002022.1	NP_002013.1	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	456					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AAGGATCCCAGACTAGCTTGG	0.498000													12	75					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20226810	20226810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20226810C>T	ENST00000245957.5	+	19	2186	c.2110C>T	c.(2110-2112)Cca>Tca	p.P704S	C20orf26_ENST00000377293.1_Missense_Mutation_p.P60S|C20orf26_ENST00000377309.2_Missense_Mutation_p.P60S|C20orf26_ENST00000389656.3_Missense_Mutation_p.P60S	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	704										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TCATGGACTCCCAGGAAAAAA	0.348000													16	73					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587447	36587447	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36587447C>T	ENST00000332987.1	-	7	1142	c.720G>A	c.(718-720)gcG>gcA	p.A240A	APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000352371.1_Silent_p.A243A			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	244					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						GGACATCATTCGCAATCATTT	0.438000													23	37					0	0	1	0	0
DROSHA	29102	broad.mit.edu	37	5	31466345	31466345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31466345G>A	ENST00000511367.2	-	18	2654	c.2410C>T	c.(2410-2412)Cta>Tta	p.L804L	DROSHA_ENST00000513349.1_Silent_p.L767L|DROSHA_ENST00000344624.3_Silent_p.L804L|DROSHA_ENST00000442743.1_Silent_p.L767L	NM_013235.4	NP_037367.3	Q9NRR4	RNC_HUMAN	drosha, ribonuclease type III	804	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(19)|lung(33)|ovary(2)|skin(1)	66						CTATTTGCTAGGAGGTGGCGA	0.428000													19	89					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124594501	124594501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124594501C>T	ENST00000368904.1	-	9	2052	c.1103G>A	c.(1102-1104)gGa>gAa	p.G368E	CUZD1_ENST00000392790.1_Missense_Mutation_p.G368E|CUZD1_ENST00000545804.1_Missense_Mutation_p.G368E			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	368	ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		AGAATTATGTCCCATTTCACA	0.358000													19	70					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	51053097	51053097	+	Missense_Mutation	SNP	G	G	A	rs78088324		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:51053097G>A	ENST00000442544.2	+	28	4838	c.4222G>A	c.(4222-4224)Gag>Aag	p.E1408K	DCC_ENST00000581580.1_Missense_Mutation_p.E1041K|RP11-671P2.1_ENST00000582064.1_RNA	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1408					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGTGTCTGAGGAGAGCCACAA	0.483000													8	88					0	0	1	0	0
CHST9	83539	broad.mit.edu	37	18	24628466	24628466	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:24628466C>T	ENST00000284224.8	-	3	400	c.121_splice	c.e3-1	p.G41_splice	CHST9_ENST00000580774.1_Splice_Site_p.G41_splice|CHST9_ENST00000581714.1_Splice_Site_p.G41_splice|AQP4-AS1_ENST00000578701.1_RNA	NM_031422.5	NP_113610.2	Q7L1S5	CHST9_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9	41					carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|skin(3)	28	all_lung(6;0.0145)|Ovarian(20;0.124)					TCTCCACTCTCCCTGAAATGA	0.358000													18	60					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47605940	47605940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47605940C>T	ENST00000263774.4	+	7	784	c.702C>T	c.(700-702)gaC>gaT	p.D234D	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	234					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	GCAAATTTGACCTGAACAGCC	0.562000													64	93					0	0	1	0	0
LRRC6	23639	broad.mit.edu	37	8	133650208	133650208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133650208G>A	ENST00000519595.1	-	4	500	c.402C>T	c.(400-402)ttC>ttT	p.F134F	LRRC6_ENST00000250173.1_Silent_p.F134F|LRRC6_ENST00000520446.1_5'UTR|LRRC6_ENST00000518642.1_Silent_p.F134F			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	134	LRRCT.					cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTGCTACCACGAACTCCCTAT	0.418000													18	68					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922292	24922292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922292C>T	ENST00000329468.2	+	1	1752	c.1278C>T	c.(1276-1278)atC>atT	p.I426I		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CTTTGCCCATCCCTGACTTGG	0.547000													28	85					0	0	1	0	0
GRAMD4	23151	broad.mit.edu	37	22	47062746	47062746	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:47062746C>T	ENST00000406902.1	+	10	1047	c.834C>T	c.(832-834)atC>atT	p.I278I	GRAMD4_ENST00000361034.3_Silent_p.I278I			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	278					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		AGTGGAGCATCGTGCCCGAAG	0.617000													45	104					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8938378	8938378	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:8938378A>C	ENST00000256707.3	-	10	1134	c.953T>G	c.(952-954)gTg>gGg	p.V318G	KIDINS220_ENST00000473731.1_Missense_Mutation_p.V318G|KIDINS220_ENST00000418530.1_Missense_Mutation_p.V276G|KIDINS220_ENST00000319688.5_Missense_Mutation_p.V319G|KIDINS220_ENST00000427284.1_Missense_Mutation_p.V318G	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	318					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GATATCTCTCACCATTGTTGC	0.328000													24	44					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533858	92533858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92533858G>A	ENST00000298047.6	+	9	7696	c.7679G>A	c.(7678-7680)cGg>cAg	p.R2560Q	FAT3_ENST00000525166.1_Missense_Mutation_p.R2410Q|FAT3_ENST00000409404.2_Missense_Mutation_p.R2560Q			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2560	Cadherin 23.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGCTAGACCGGGAAAACCCT	0.473000										TCGA Ovarian(4;0.039)			11	27					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20556494	20556494	+	Silent	SNP	G	G	A	rs141823499		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20556494G>A	ENST00000329697.6	-	10	1434	c.1266C>T	c.(1264-1266)atC>atT	p.I422I	ACSM2B_ENST00000565322.1_Silent_p.I343I|ACSM2B_ENST00000567001.1_Silent_p.I422I|ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565232.1_Silent_p.I422I	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	422					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						AGCCAGAGAAGATGCCTATAG	0.517000													22	80					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88761443	88761443	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88761443C>T	ENST00000444431.1	+	0	2573				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										CGACAATATTCCTTGATGGCA	0.373000													62	134					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269468	30269468	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:30269468C>T	ENST00000378981.3	+	4	1179	c.858C>T	c.(856-858)ctC>ctT	p.L286L	MAGEB1_ENST00000397548.2_Silent_p.L286L|MAGEB1_ENST00000397550.1_Silent_p.L286L	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	286	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						TGAAAGTCCTCGAGTTTTTGG	0.507000													46	30					0	0	1	0	0
IFT80	57560	broad.mit.edu	37	3	159997081	159997081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159997081G>A	ENST00000326448.7	-	16	2168	c.1736C>T	c.(1735-1737)tCc>tTc	p.S579F	IFT80_ENST00000496589.1_Missense_Mutation_p.S442F|RP11-432B6.3_ENST00000483754.1_Missense_Mutation_p.S750F|IFT80_ENST00000483465.1_Missense_Mutation_p.S442F	NM_020800.2	NP_065851.1	Q9P2H3	IFT80_HUMAN	intraflagellar transport 80 homolog (Chlamydomonas)	579						cilium axoneme|microtubule basal body				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(12)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GTGAACCAGGGAGCCATCAGC	0.358000													26	55					0	0	1	0	0
SPRY1	10252	broad.mit.edu	37	4	124323283	124323283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:124323283C>T	ENST00000394339.2	+	2	877	c.537C>T	c.(535-537)ttC>ttT	p.F179F	SPRY1_ENST00000339241.1_Silent_p.F179F	NM_001258039.1|NM_005841.2	NP_001244968.1|NP_005832.1	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	179					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				NS(1)|large_intestine(4)|lung(2)|ovary(1)|skin(3)	11						AGCACAAGTTCATTTGTGAAC	0.527000													34	71					0	0	1	0	0
ALX3	257	broad.mit.edu	37	1	110612973	110612973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110612973C>T	ENST00000369792.4	-	1	349	c.262G>A	c.(262-264)Gag>Aag	p.E88K		NM_006492.2	NP_006483.2	O95076	ALX3_HUMAN	ALX homeobox 3	88						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6		all_cancers(81;2.35e-05)|all_epithelial(167;7.69e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.015)|all cancers(265;0.0706)|Epithelial(280;0.0758)|Colorectal(144;0.113)|LUSC - Lung squamous cell carcinoma(189;0.135)		GCGGGGCCCTCGTAGAAGTGG	0.731000													4	19					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611619	179611619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179611619G>A	ENST00000360870.5	-	46	15730	c.15508C>T	c.(15508-15510)Ccc>Tcc	p.P5170S	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	7087	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCATTGGGTGTACCAAAT	0.408000													55	111					0	0	1	0	0
METTL21C	196541	broad.mit.edu	37	13	103339317	103339317	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:103339317G>A	ENST00000267273.6	-	3	378	c.373C>T	c.(373-375)Ctt>Ttt	p.L125F		NM_001010977.1	NP_001010977.1	Q5VZV1	MT21C_HUMAN	methyltransferase like 21C	125							methyltransferase activity			breast(1)|large_intestine(3)|lung(2)|skin(1)	7						ATGGAAACAAGGCCTGGTCCG	0.388000													18	64					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3265439	3265439	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3265439A>G	ENST00000520002.1	-	15	2611	c.2056T>C	c.(2056-2058)Ttc>Ctc	p.F686L	CSMD1_ENST00000542608.1_Missense_Mutation_p.F685L|CSMD1_ENST00000400186.3_Missense_Mutation_p.F686L|CSMD1_ENST00000602557.1_Missense_Mutation_p.F686L|CSMD1_ENST00000537824.1_Missense_Mutation_p.F685L|CSMD1_ENST00000602723.1_Missense_Mutation_p.F686L|CSMD1_ENST00000539096.1_Missense_Mutation_p.F685L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	686	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGATGTTGAACCCTCTGCCA	0.448000													4	11					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71317926	71317926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71317926G>A	ENST00000338099.5	-	3	2234	c.1898C>T	c.(1897-1899)tCa>tTa	p.S633L	FTSJD1_ENST00000434935.2_Missense_Mutation_p.S633L			Q8IYT2	FTSJ1_HUMAN		633						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTCCCGCAATGAATGTAGAAG	0.403000													9	94					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23635600	23635600	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23635600G>A	ENST00000316902.7	-	2	1026	c.301C>T	c.(301-303)Ccc>Tcc	p.P101S	SLC7A8_ENST00000469263.1_Missense_Mutation_p.P101S	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	101					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CCAGATTTGGGGATGGTGACC	0.542000													87	186					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124172600	124172600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124172600C>T	ENST00000303372.5	+	7	895	c.767C>T	c.(766-768)tCc>tTc	p.S256F	TCTN2_ENST00000426174.2_Missense_Mutation_p.S255F	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	256					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		ATTTTCAGTTCCCCCAAACAG	0.368000													48	164					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62675662	62675662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62675662G>A	ENST00000498273.1	+	4	1511	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	406	Glu-rich.									breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						GCTggaggaggaggaggaaga	0.547000													19	47					0	0	1	0	0
ULK1	8408	broad.mit.edu	37	12	132400950	132400950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:132400950C>T	ENST00000321867.4	+	20	2237	c.1886C>T	c.(1885-1887)cCc>cTc	p.P629L		NM_003565.2	NP_003556.1	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	629					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TAGGCTGTGCCCTCCTTTGAC	0.692000													18	120					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	817443	817443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:817443C>T	ENST00000566549.1	+	15	1986	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F	MSLN_ENST00000382862.3_Silent_p.F531F|MSLN_ENST00000545450.2_Silent_p.F523F|MSLN_ENST00000563941.1_Silent_p.F523F			Q13421	MSLN_HUMAN	mesothelin	531					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				TGGCCACGTTCATGAAGCTGC	0.697000													32	83					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027304	37027304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37027304C>T	ENST00000358047.3	+	1	873	c.821C>T	c.(820-822)cCt>cTt	p.P274L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	274										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TACCTGGAGCCTCCTGGGACT	0.607000													47	16					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3679786	3679786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3679786G>A	ENST00000294600.2	+	7	1153	c.1069G>A	c.(1069-1071)Gga>Aga	p.G357R		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	357	Glu-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		GGGTGCCTGGGGAGGTGTGAG	0.672000													5	5					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43594369	43594369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43594369G>A	ENST00000395891.1	+	29	5294	c.4689G>A	c.(4687-4689)ggG>ggA	p.G1563G	HECW1_ENST00000453890.1_Silent_p.G1529G	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1563	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.G1542G(1)		NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						AGAAATGGGGGAAAATTACTT	0.527000													4	24					0	0	1	0	0
GNA14	9630	broad.mit.edu	37	9	80144023	80144023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:80144023C>T	ENST00000341700.6	-	2	784	c.271G>A	c.(271-273)Gac>Aac	p.D91N		NM_004297.3	NP_004288.1	O95837	GNA14_HUMAN	guanine nucleotide binding protein (G protein), alpha 14	91					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	24						CTTAGCGTGTCCATCGCTCTG	0.478000													39	185					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596633	179596633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179596633G>A	ENST00000589042.1	-	58	17193	c.16969C>T	c.(16969-16971)Ctg>Ttg	p.L5657L	TTN_ENST00000342992.6_Silent_p.L4413L|TTN_ENST00000591111.1_Silent_p.L5340L|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5340	Ig-like 37.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTCAGCCAGCAACATGACA	0.403000													28	103					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175360448	175360448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175360448G>A	ENST00000367674.1	-	7	2191	c.1483C>T	c.(1483-1485)Cct>Tct	p.P495S	TNR_ENST00000263525.2_Missense_Mutation_p.P495S	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	495	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GCCGAGGTAGGGGGGCTGCGG	0.557000													31	62					0	0	1	0	0
AMTN	401138	broad.mit.edu	37	4	71389609	71389609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71389609C>T	ENST00000339336.4	+	4	293	c.163C>T	c.(163-165)Cca>Tca	p.P55S	AMTN_ENST00000504451.1_Missense_Mutation_p.P54S	NM_212557.2	NP_997722.1	Q6UX39	AMTN_HUMAN	amelotin	55					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				NS(3)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)|skin(1)	19			Lung(101;0.235)			AAGTCTGATACCATTAACACA	0.388000													52	108					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508298	106508298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:106508298C>T	ENST00000359195.3	+	2	602	c.292C>T	c.(292-294)Ctg>Ttg	p.L98L	PIK3CG_ENST00000440650.2_Silent_p.L98L|PIK3CG_ENST00000496166.1_Silent_p.L98L	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	98					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						TCACTTCCTCCTGCTCTATCA	0.627000													9	30					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167678	140167678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140167678G>A	ENST00000504120.2	+	1	1803	c.1803G>A	c.(1801-1803)tcG>tcA	p.S601S	PCDHA1_ENST00000378133.3_Silent_p.S601S|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCCGACTCGGGCTACAACG	0.667000													45	94					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104032288	104032288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104032288G>A	ENST00000374874.3	+	3	629	c.190G>A	c.(190-192)Gaa>Aaa	p.E64K	LPPR1_ENST00000395056.2_Missense_Mutation_p.E64K	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		64						integral to membrane	catalytic activity										AGGGACAGAGGAAGAAAGCTT	0.463000													4	50					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28997319	28997319	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:28997319C>T	ENST00000322982.3	-	0	615				AC005013.5_ENST00000436594.1_lincRNA			Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GAGGTTGTTCCCCAGGTACAG	0.657000													4	11					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142572875	142572875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142572875C>T	ENST00000359396.3	-	9	1410	c.1165G>A	c.(1165-1167)Gag>Aag	p.E389K		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	389					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					GTCACCAGCTCCCCGACCAGC	0.562000													19	99					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111398053	111398053	+	Silent	SNP	C	C	T	rs146450390		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111398053C>T	ENST00000265162.5	+	1	825	c.483C>T	c.(481-483)ttC>ttT	p.F161F		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	161					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding	p.F161F(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GGAGGTGTTTCGAGTACAAAA	0.627000													54	143					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74644533	74644533	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:74644533G>A	ENST00000541184.1	-	7	1140	c.663C>T	c.(661-663)ctC>ctT	p.L221L	ZDHHC15_ENST00000373367.3_Silent_p.L230L|ZDHHC15_ENST00000373361.3_3'UTR	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	230						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						GGTAACCAAAGAGAATCACAA	0.383000													15	12					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78790148	78790148	+	Missense_Mutation	SNP	G	G	A	rs68105355		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78790148G>A	ENST00000376767.3	+	14	2515	c.2003G>A	c.(2002-2004)gGa>gAa	p.G668E	PCSK5_ENST00000376752.4_Intron|PCSK5_ENST00000545128.1_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						aaatggaatggaatgaaatgg	0.413000													4	11					0	0	1	0	0
TRAV40	28641	broad.mit.edu	37	14	22783078	22783078	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22783078G>A	ENST00000390467.3	+	0	44																											CCCCCTACAGGAGGAACCAGC	0.408000													19	24					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54901636	54901636	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54901636G>A	ENST00000293373.6	+	4	385		c.e4-1		NCKAP1L_ENST00000545638.2_Splice_Site	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like						actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TCCACCCCCAGGATCATGTAT	0.413000													51	163					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52395327	52395327	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52395327C>T	ENST00000420323.2	+	29	5094	c.4833C>T	c.(4831-4833)ctC>ctT	p.L1611L	DNAH1_ENST00000466628.1_3'UTR	NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1611	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTGACCAGCTCGACTTCATGG	0.607000													5	15					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325546	31325546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31325546C>T	ENST00000269197.5	+	12	5734	c.5734C>T	c.(5734-5736)Cat>Tat	p.H1912Y		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1912					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GAACCTATTTCATGTTGACAA	0.527000													30	133					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4935978	4935978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4935978C>T	ENST00000322013.3	-	1	944	c.916G>A	c.(916-918)Gat>Aat	p.D306N	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTCACTCGATCCCGGATCTGT	0.468000													8	33					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35242163	35242163	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:35242163C>T	ENST00000408931.3	-	8	1749	c.1223G>A	c.(1222-1224)gGg>gAg	p.G408E		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	408						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GGGGCCACTCCCTTGCATGGA	0.552000													7	29					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612740	20612740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20612740G>A	ENST00000333629.1	+	1	846	c.846G>A	c.(844-846)atG>atA	p.M282I		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TTCCTTTGATGAACCCTGTTA	0.413000													70	163					0	0	1	0	0
CDHR4	389118	broad.mit.edu	37	3	49836227	49836227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49836227C>T	ENST00000487256.1	-	4	549	c.527G>A	c.(526-528)aGg>aAg	p.R176K	CDHR4_ENST00000343366.4_3'UTR|CDHR4_ENST00000412678.2_Intron			A6H8M9	CDHR4_HUMAN	cadherin-related family member 4	0					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(3)	11						CACCCCCATCCTGTCACCCAC	0.592000													13	24					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76386875	76386875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76386875C>T	ENST00000370014.3	+	14	2370	c.1751C>T	c.(1750-1752)cCc>cTc	p.P584L	SENP6_ENST00000327284.8_Missense_Mutation_p.P577L|SENP6_ENST00000370010.2_Missense_Mutation_p.P577L|SENP6_ENST00000447266.2_Missense_Mutation_p.P584L|SENP6_ENST00000541192.1_Missense_Mutation_p.P180L	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	584					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				GCGAAAATTCCCTTTGAAGAA	0.343000													9	43					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940437	22940437	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22940437C>T	ENST00000397104.3	-	5	2000	c.2001G>A	c.(1999-2001)gaG>gaA	p.E667E	ZNF99_ENST00000596209.1_Silent_p.E758E					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGCAGGGTTTCTCTGCAGTAT	0.353000													6	86					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24245745	24245745	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:24245745G>A	ENST00000338315.4	+	10	1032	c.1032G>A	c.(1030-1032)ggG>ggA	p.G344G	MFSD2B_ENST00000406420.3_Silent_p.G344G			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	344					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						AGCGCTTTGGGAAGAAGACGT	0.632000													4	18					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57499062	57499062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57499062C>T	ENST00000420954.2	-	8	749	c.714G>A	c.(712-714)acG>acA	p.T238T	DAB1_ENST00000439789.2_Silent_p.T154T|DAB1_ENST00000371234.4_Intron|DAB1_ENST00000371231.1_Silent_p.T273T|DAB1_ENST00000371236.2_Intron|DAB1_ENST00000414851.2_Intron|DAB1_ENST00000485760.1_Intron			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	273					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCCTTACCTTCGTTGCCTCAA	0.413000													66	77					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2317866	2317866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2317866G>A	ENST00000222990.3	-	2	211	c.169C>T	c.(169-171)Ccg>Tcg	p.P57S		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	57					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		TTCCCCTGCGGCATCTGCATT	0.652000													20	45					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967301	41967301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41967301G>A	ENST00000298919.7	+	10	2328	c.1940G>A	c.(1939-1941)cGa>cAa	p.R647Q	PDZRN4_ENST00000539469.2_Missense_Mutation_p.R649Q|PDZRN4_ENST00000402685.2_Missense_Mutation_p.R907Q			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	907							ubiquitin-protein ligase activity|zinc ion binding	p.R649Q(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AGACCCGTGCGAGACCGAATC	0.517000													8	104					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248039742	248039742	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248039742C>T	ENST00000366481.3	+	6	1460	c.1412C>T	c.(1411-1413)tCc>tTc	p.S471F	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	471						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AATTGGGCATCCAGGGATCAT	0.463000													19	53					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164131	139164131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139164131G>A	ENST00000395297.1	-	13	2757	c.2587C>T	c.(2587-2589)Cct>Tct	p.P863S		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	863										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGCCATCAGGAAGACAGTGT	0.478000										HNSCC(54;0.14)			9	85					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102477362	102477362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102477362G>A	ENST00000260228.2	-	6	869	c.857C>T	c.(856-858)cCc>cTc	p.P286L	MMP20_ENST00000544938.1_5'UTR	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	286					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CTTGTGATGGGGGGCATGGGG	0.527000													22	61					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53303045	53303045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53303045G>A	ENST00000438150.2	-	2	2787	c.1894C>T	c.(1894-1896)Cat>Tat	p.H632Y	ZNF28_ENST00000457749.2_Missense_Mutation_p.H685Y|ZNF28_ENST00000360272.4_Missense_Mutation_p.H632Y|ZNF28_ENST00000414252.2_Missense_Mutation_p.H632Y			P17035	ZNF28_HUMAN	zinc finger protein 28	685					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TCTCCAGTATGAACTCTCTGA	0.408000													53	184					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908370	103908370	+	Missense_Mutation	SNP	G	G	A	rs145758335		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103908370G>A	ENST00000302259.3	+	1	1063	c.820G>A	c.(820-822)Gag>Aag	p.E274K	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	274					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GGCTTGTGCCGAGCGATGTAA	0.517000													40	104					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166152571	166152571	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166152571G>A	ENST00000357398.3	+	2	528	c.238G>A	c.(238-240)Gat>Aat	p.D80N	SCN2A_ENST00000375437.2_Missense_Mutation_p.D80N|SCN2A_ENST00000375427.2_Missense_Mutation_p.D80N|SCN2A_ENST00000283256.6_Missense_Mutation_p.D80N			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	80					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GCCCCTGGAGGATCTGGACCC	0.448000													14	64					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119958174	119958174	+	Silent	SNP	G	G	A	rs111333222	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119958174G>A	ENST00000543831.1	+	2	381	c.132G>A	c.(130-132)gaG>gaA	p.E44E	HSD3B2_ENST00000369416.3_Silent_p.E44E|HSD3B2_ENST00000471656.1_3'UTR	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	44					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	AATTGAGAGAGGAATTTTCTA	0.498000													41	102					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97852938	97852938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97852938C>T	ENST00000420699.2	+	31	2289	c.2045C>T	c.(2044-2046)tCt>tTt	p.S682F	ANKRD36_ENST00000461153.2_Missense_Mutation_p.S682F	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	682										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						TTTTCAGTGTCTTCTCAGAAA	0.323000													12	47					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39068823	39068823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39068823C>T	ENST00000355481.4	+	98	14459	c.14328C>T	c.(14326-14328)ttC>ttT	p.F4776F	RYR1_ENST00000359596.3_Silent_p.F4781F|RYR1_ENST00000360985.3_Silent_p.F4776F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4781					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.F4781F(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCTGGAAGTTCGGGGTCATCT	0.607000													5	34					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71906994	71906994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71906994C>T	ENST00000393679.1	+	5	983	c.547C>T	c.(547-549)Ccc>Tcc	p.P183S	FOLR1_ENST00000393676.3_Missense_Mutation_p.P183S|FOLR1_ENST00000312293.4_Missense_Mutation_p.P183S|RP11-807H22.7_ENST00000378140.3_RNA|FOLR1_ENST00000393681.2_Missense_Mutation_p.P183S			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	183					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						TTTCTACTTCCCCACACCCAC	0.547000													10	113					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105947179	105947179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105947179C>T	ENST00000357060.3	-	14	1874	c.1759G>A	c.(1759-1761)Gag>Aag	p.E587K	WDR96_ENST00000428666.1_Missense_Mutation_p.E588K|WDR96_ENST00000278064.2_Missense_Mutation_p.E518K	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	587										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AGAGCGTGCTCCAACTCATAC	0.403000													29	55					0	0	1	0	0
TIGD3	220359	broad.mit.edu	37	11	65124002	65124002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65124002C>T	ENST00000309880.5	+	2	930	c.723C>T	c.(721-723)atC>atT	p.I241I		NM_145719.2	NP_663771.1	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	241	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(3)|large_intestine(1)|lung(9)|prostate(2)|skin(2)	17						ACCTGGGCATCCCCTGGTTAG	0.657000													35	133					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	132110674	132110674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132110674C>T	ENST00000404460.1	+	7	559	c.505C>T	c.(505-507)Ccc>Tcc	p.P169S	PLEKHB2_ENST00000303908.3_Missense_Mutation_p.P169S			Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	0						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		ATGTTTTTTTCCCAGCGAATC	0.478000													7	27					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8234962	8234962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8234962C>T	ENST00000339754.5	+	1	156	c.78C>T	c.(76-78)gcC>gcT	p.A26A		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	26					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		CGCCCCGGGCCTCCAACCGCG	0.632000													5	23					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51382068	51382068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51382068G>A	ENST00000216392.7	-	11	1721	c.1389C>T	c.(1387-1389)atC>atT	p.I463I	PYGL_ENST00000532462.1_Silent_p.I463I|PYGL_ENST00000544180.2_Silent_p.I429I	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	463					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding	p.I463I(1)		NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TAGTCTTCACGATGTCTGAGT	0.473000													17	200					0	0	1	0	0
FZD6	8323	broad.mit.edu	37	8	104337524	104337524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:104337524G>A	ENST00000358755.4	+	4	1507	c.1190G>A	c.(1189-1191)cGa>cAa	p.R397Q	FZD6_ENST00000522566.1_Missense_Mutation_p.R397Q|FZD6_ENST00000523739.1_Missense_Mutation_p.R365Q|FZD6_ENST00000540287.1_Missense_Mutation_p.R92Q	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	397					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding	p.R397Q(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			AATCATGTTCGACAAGTCATA	0.413000													77	208					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110477348	110477348	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:110477348G>A	ENST00000260283.4	-	10	1185	c.901C>T	c.(901-903)Cga>Tga	p.R301*	ARHGAP20_ENST00000528829.1_Nonsense_Mutation_p.R265*|ARHGAP20_ENST00000524756.1_Nonsense_Mutation_p.R278*|ARHGAP20_ENST00000527598.1_Nonsense_Mutation_p.R265*|ARHGAP20_ENST00000533353.1_Nonsense_Mutation_p.R275*|ARHGAP20_ENST00000357139.3_Nonsense_Mutation_p.R275*	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	301					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TGCATCTCTCGGGGGAGCTGT	0.542000													94	200					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113510953	113510953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113510953G>A	ENST00000505019.1	-	11	3179	c.3054C>T	c.(3052-3054)ttC>ttT	p.F1018F	C4orf21_ENST00000309071.5_Silent_p.F1018F	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	1018										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ATTCTACCATGAAGTCTTCAT	0.383000													27	85					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887907	97887907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97887907C>T	ENST00000356526.2	+	1	364	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						GGCATATGATCGCTATGTAGC	0.378000													27	162					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46755035	46755035	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:46755035C>T	ENST00000394809.4	-	9	2100	c.1985_splice	c.e9+1	p.R662_splice	MYLK3_ENST00000536476.1_Splice_Site_p.R321_splice	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	662	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				ACCCCCTTACCTTCTGGCCAG	0.448000													15	136					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155720365	155720365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155720365C>T	ENST00000510397.1	+	4	1230	c.1051C>T	c.(1051-1053)Cct>Tct	p.P351S	RBM46_ENST00000281722.3_Missense_Mutation_p.P351S|RBM46_ENST00000514866.1_Missense_Mutation_p.P351S	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	351							nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				GCCAACTCTTCCTGCTCGTCT	0.423000													37	73					0	0	1	0	0
RBM38	55544	broad.mit.edu	37	20	55982841	55982841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:55982841C>T	ENST00000356208.5	+	4	834	c.659C>T	c.(658-660)cCc>cTc	p.P220L	RBM38_ENST00000371219.2_Missense_Mutation_p.P139L	NM_017495.5	NP_059965.2	Q9H0Z9	RBM38_HUMAN	RNA binding motif protein 38	220					3'-UTR-mediated mRNA stabilization|cell cycle|cell cycle arrest|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mRNA processing|negative regulation of cell proliferation|regulation of RNA splicing|RNA splicing	cytosol|nucleus	mRNA 3'-UTR binding|mRNA binding|nucleotide binding|RNA binding			large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Lung NSC(12;0.00242)|all_lung(29;0.00767)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.55e-12)|Epithelial(14;9.49e-09)|all cancers(14;5.01e-08)			GCCGCAGCACCCGCGGGCACC	0.672000													3	3					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115973129	115973129	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115973129G>A	ENST00000251864.2	+	15	2009	c.1856G>A	c.(1855-1857)tGg>tAg	p.W619*	TDRD1_ENST00000422662.1_Nonsense_Mutation_p.W223*|TDRD1_ENST00000369281.2_Nonsense_Mutation_p.W562*|TDRD1_ENST00000369282.1_Nonsense_Mutation_p.W619*|TDRD1_ENST00000369280.1_Nonsense_Mutation_p.W619*	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	619					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TTAGGAATTTGGACTCCAGAA	0.358000													19	93					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13613147	13613147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13613147G>A	ENST00000404922.3	+	2	1411	c.1292G>A	c.(1291-1293)aGa>aAa	p.R431K	FBLN2_ENST00000535798.1_Missense_Mutation_p.R457K|FBLN2_ENST00000492059.1_Missense_Mutation_p.R431K|FBLN2_ENST00000295760.7_Missense_Mutation_p.R431K	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	431	N.|Subdomain NB (Cys-free).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			TCTATCCCCAGAAGTAGCCCT	0.612000													7	15					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134670844	134670844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134670844G>A	ENST00000398015.3	+	3	1125	c.755G>A	c.(754-756)cGa>cAa	p.R252Q	EPHB1_ENST00000488154.1_Intron	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	252	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CCTATTGGGCGATGCACCTGC	0.577000													49	128					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62516686	62516686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62516686G>A	ENST00000371158.2	+	31	4195	c.4081G>A	c.(4081-4083)Gaa>Aaa	p.E1361K	INADL_ENST00000545929.1_Missense_Mutation_p.E34K|INADL_ENST00000316485.6_Missense_Mutation_p.E1361K|INADL_ENST00000543708.1_Missense_Mutation_p.E145K	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1361					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TGGCAGCGTCGAAGTTGGTAT	0.388000													13	36					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135480069	135480069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135480069G>A	ENST00000394143.1	+	20	8505	c.8214G>A	c.(8212-8214)gtG>gtA	p.V2738V	GPR112_ENST00000370652.1_Silent_p.V2738V|GPR112_ENST00000394141.1_Silent_p.V2533V|GPR112_ENST00000412101.1_Silent_p.V2533V|GPR112_ENST00000287534.4_Silent_p.V2491V	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2738					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGGATTCAGTGAATGAACAGA	0.403000													29	57					0	0	1	0	0
KLK7	5650	broad.mit.edu	37	19	51483734	51483734	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51483734G>A	ENST00000391807.1	-	4	332	c.231C>T	c.(229-231)acC>acT	p.T77T	KLK7_ENST00000595820.1_Silent_p.T77T|CTB-147C22.9_ENST00000594512.1_RNA|KLK7_ENST00000336317.4_5'UTR|KLK7_ENST00000597707.1_Silent_p.T5T	NM_139277.2	NP_644806.1	P49862	KLK7_HUMAN	kallikrein-related peptidase 7	77	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(2)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		CCAGGTGCACGGTGTACTCAC	0.582000													9	57					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85710914	85710914	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85710914G>A	ENST00000322366.6	-	22	4041	c.3634C>T	c.(3634-3636)Ctt>Ttt	p.L1212F	WDFY3_ENST00000295888.4_Missense_Mutation_p.L1212F			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1212						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCAATATAAAGGGCTGCAGTA	0.428000													32	91					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45670699	45670699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45670699G>A	ENST00000270172.3	-	10	1386	c.903C>T	c.(901-903)ttC>ttT	p.F301F	AP001059.5_ENST00000442785.1_RNA|DNMT3L_ENST00000418993.1_Silent_p.F301F	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	301					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		GCACCTCCAGGAAGCGAGATG	0.647000													30	92					0	0	1	0	0
GATSL3	652968	broad.mit.edu	37	22	30682303	30682303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30682303G>A	ENST00000407689.3	-	6	821	c.692C>T	c.(691-693)tCc>tTc	p.S231F	GATSL3_ENST00000459785.1_Intron|RP1-130H16.18_ENST00000447976.1_3'UTR|GATSL3_ENST00000404953.3_Intron	NM_001037666.2	NP_001032755.1			GATS protein-like 3											breast(1)|endometrium(1)|lung(1)	3						CTCGATGAGGGAGAAGGCAAA	0.592000													10	49					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35631136	35631136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:35631136G>A	ENST00000353139.5	-	9	1437	c.956C>T	c.(955-957)cCc>cTc	p.P319L	ACACA_ENST00000394406.2_Missense_Mutation_p.P282L|ACACA_ENST00000360679.3_Missense_Mutation_p.P224L|ACACA_ENST00000335166.5_Missense_Mutation_p.P204L	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	282	ATP-grasp.|Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TAGCTCCTGGGGAACATTTAA	0.413000													38	65					0	0	1	0	0
TRAV27	28655	broad.mit.edu	37	14	22616535	22616535	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22616535C>T	ENST00000390457.2	+	0	373																											ACAGTTCTCTCCACATCACTG	0.542000													23	60					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87489305	87489305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87489305G>A	ENST00000327946.7	-	9	1385	c.1300C>T	c.(1300-1302)Ctc>Ttc	p.L434F	GRID1_ENST00000536331.1_Missense_Mutation_p.L5F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	434						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AATCCTTGGAGGCGGCTGCCC	0.517000										Multiple Myeloma(13;0.14)			27	66					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777014	18777014	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18777014C>T	ENST00000380548.4	+	19	3126	c.2787C>T	c.(2785-2787)ttC>ttT	p.F929F		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	929	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TGGCCCCCTTCGGCTATCTCA	0.662000													23	56					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116744716	116744716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:116744716G>A	ENST00000375300.1	-	12	1489	c.1484C>T	c.(1483-1485)cCc>cTc	p.P495L	SIK3_ENST00000292055.4_Missense_Mutation_p.P437L|SIK3_ENST00000375288.1_5'UTR|SIK3_ENST00000542607.1_Missense_Mutation_p.P389L|SIK3_ENST00000434315.2_Missense_Mutation_p.P336L|SIK3_ENST00000446921.2_Missense_Mutation_p.P447L			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	437						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						TGGAGCCTGGGGGTTGACTCC	0.468000													31	100					0	0	1	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010549	24010549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:24010549G>A	ENST00000496398.1	+	4	1009	c.586G>A	c.(586-588)Gag>Aag	p.E196K	RP11-255H23.4_ENST00000599944.1_lincRNA|RP11-255H23.2_ENST00000471224.1_RNA|RPSAP58_ENST00000354585.4_Missense_Mutation_p.E196K																endometrium(1)|kidney(5)|lung(2)|prostate(1)|urinary_tract(1)	10						ACACCCATGGGAGGTCATGCC	0.522000													10	27					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	38997504	38997504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38997504C>T	ENST00000400482.3	-	4	1818	c.1229G>A	c.(1228-1230)aGa>aAa	p.R410K	KCNJ6_ENST00000288309.6_Missense_Mutation_p.R410K	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	410					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	ATCACCATTTCTTTCTGTTTG	0.478000													54	207					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56899349	56899349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56899349G>A	ENST00000438926.2	+	1	231	c.202G>A	c.(202-204)Gag>Aag	p.E68K	SLC12A3_ENST00000566786.1_Missense_Mutation_p.E68K|SLC12A3_ENST00000262502.5_Missense_Mutation_p.E68K|SLC12A3_ENST00000563236.1_Missense_Mutation_p.E68K	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	68			E -> K (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GCCCACATATGAGCACTATGC	0.592000													37	109					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233372723	233372723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233372723C>T	ENST00000258229.8	-	9	2460	c.2226G>A	c.(2224-2226)gaG>gaA	p.E742E	PCNXL2_ENST00000430153.1_Silent_p.E41E	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	742						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TGACCTGCATCTCTCTGAGGA	0.473000													14	52					0	0	1	0	0
DTNA	1837	broad.mit.edu	37	18	32459583	32459583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:32459583C>T	ENST00000283365.9	+	19	2161	c.1810C>T	c.(1810-1812)Ccc>Tcc	p.P604S	DTNA_ENST00000591182.1_Missense_Mutation_p.P309S|DTNA_ENST00000590831.2_Missense_Mutation_p.P87S|DTNA_ENST00000598142.1_Missense_Mutation_p.P604S|DTNA_ENST00000598334.1_Missense_Mutation_p.P601S|DTNA_ENST00000399121.5_Missense_Mutation_p.P608S|DTNA_ENST00000399113.3_Missense_Mutation_p.P661S|DTNA_ENST00000556414.3_Missense_Mutation_p.P313S|DTNA_ENST00000399097.3_Missense_Mutation_p.P309S|DTNA_ENST00000601125.1_Missense_Mutation_p.P283S|DTNA_ENST00000595022.1_Missense_Mutation_p.P601S|DTNA_ENST00000444659.1_Missense_Mutation_p.P661S|DTNA_ENST00000269190.7_Missense_Mutation_p.P662S|DTNA_ENST00000269192.7_Missense_Mutation_p.P370S	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	661					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						GGATCTTGTTCCCTCACCAAC	0.448000													12	49					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21227219	21227219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21227219G>A	ENST00000233242.1	-	28	12136	c.12009C>T	c.(12007-12009)tcC>tcT	p.S4003S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4003					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTACGGCTGGGGAGGCTGCTG	0.502000													17	88					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306412	54306412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54306412G>A	ENST00000545554.1	+	1	1312	c.1312G>A	c.(1312-1314)Gag>Aag	p.E438K	UNC13C_ENST00000537900.1_Missense_Mutation_p.E438K|UNC13C_ENST00000260323.11_Missense_Mutation_p.E438K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	438					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTCTACTCCAGAGCCAAAAAT	0.408000													39	71					0	0	1	0	0
SLC19A2	10560	broad.mit.edu	37	1	169446940	169446940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169446940G>A	ENST00000236137.5	-	2	496	c.260C>T	c.(259-261)cCt>cTt	p.P87L	SLC19A2_ENST00000367804.3_Intron|SLC19A2_ENST00000367802.3_Missense_Mutation_p.P87L	NM_006996.2	NP_008927.1	O60779	S19A2_HUMAN	solute carrier family 19 (thiamine transporter), member 2	87					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.208)					AAGGAACACAGGAAACAGTAG	0.403000													10	21					0	0	1	0	0
WDR75	84128	broad.mit.edu	37	2	190340087	190340087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:190340087G>A	ENST00000314761.4	+	21	2497	c.2437G>A	c.(2437-2439)Gaa>Aaa	p.E813K		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	813						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AAAATCTGAAGAAAAAGAACT	0.368000													9	50					0	0	1	0	0
NUCB2	4925	broad.mit.edu	37	11	17323410	17323410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17323410C>T	ENST00000529010.1	+	5	591	c.372C>T	c.(370-372)tcC>tcT	p.S124S	NUCB2_ENST00000458064.2_Silent_p.S124S|NUCB2_ENST00000323688.6_Silent_p.S124S	NM_005013.2	NP_005004.1	P80303	NUCB2_HUMAN	nucleobindin 2	124						cytosol|ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|plasma membrane	calcium ion binding|DNA binding			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						AGTTGGATTCCCTTCAAGGTA	0.378000													22	64					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87285691	87285691	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:87285691C>A	ENST00000304053.6	+	2	511	c.28C>A	c.(28-30)Ccc>Acc	p.P10T	NTRK2_ENST00000323115.4_Missense_Mutation_p.P10T|NTRK2_ENST00000376213.1_Missense_Mutation_p.P10T|NTRK2_ENST00000359847.3_Missense_Mutation_p.P10T|NTRK2_ENST00000277120.3_Missense_Mutation_p.P10T|NTRK2_ENST00000376208.1_Missense_Mutation_p.P10T|NTRK2_ENST00000395882.1_Missense_Mutation_p.P10T|NTRK2_ENST00000376214.1_Missense_Mutation_p.P10T	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	10					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						GTGGCATGGACCCGCCATGGC	0.677000										TSP Lung(25;0.17)			20	118					2.27731e-05	2.28137e-05	1	1	0
FAM90A1	55138	broad.mit.edu	37	12	8376712	8376712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8376712C>T	ENST00000538603.1	-	5	781	c.223G>A	c.(223-225)Gaa>Aaa	p.E75K	FAM90A1_ENST00000307435.6_Missense_Mutation_p.E75K	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	75							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		CCTTCCTTTTCCCCAAAGTTC	0.547000													27	138					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143388	55143388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55143388G>A	ENST00000396331.1	+	6	718	c.361G>A	c.(361-363)Gcc>Acc	p.A121T	LILRB1_ENST00000448689.1_Missense_Mutation_p.A121T|LILRB1_ENST00000434867.2_Missense_Mutation_p.A121T|LILRB1_ENST00000396332.4_Missense_Mutation_p.A121T|LILRB1_ENST00000427581.2_Missense_Mutation_p.A157T|LILRB1_ENST00000324602.7_Missense_Mutation_p.A121T|LILRB1_ENST00000418536.2_Missense_Mutation_p.A121T|LILRB1_ENST00000396317.1_Missense_Mutation_p.A121T|LILRB1_ENST00000396321.2_Missense_Mutation_p.A121T|LILRB1_ENST00000396315.1_Missense_Mutation_p.A121T|LILRB1_ENST00000396327.3_Missense_Mutation_p.A121T	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	121	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TCTCCTAGGAGCCTACATCAA	0.597000										HNSCC(37;0.09)			9	110					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21235486	21235486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21235486G>A	ENST00000233242.1	-	26	4381	c.4254C>T	c.(4252-4254)ttC>ttT	p.F1418F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1418				F -> S (in Ref. 5; CAA28420).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGATAGTGTGAACGTATTCT	0.348000													28	67					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21178778	21178778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21178778G>A	ENST00000377122.4	-	3	650	c.254C>T	c.(253-255)tCt>tTt	p.S85F	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron|NEBL_ENST00000377119.1_Missense_Mutation_p.S85F	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	85					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CCTTACCTCAGAAATAAAAGC	0.308000													25	58					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580592	140580592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580592C>T	ENST00000354757.3	+	1	1245	c.1245C>T	c.(1243-1245)gcC>gcT	p.A415A	PCDHB11_ENST00000536699.1_Silent_p.A50A	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		415	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGCACAGCCGAGTACAATA	0.493000													30	128					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46627726	46627726	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46627726G>A	ENST00000470495.1	-	2	2713	c.1266C>T	c.(1264-1266)atC>atT	p.I422I	HOXB-AS1_ENST00000508688.1_RNA|HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000490677.1_Silent_p.I288I|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000489475.1_Silent_p.I349I|HOXB3_ENST00000485909.2_Silent_p.I290I|HOXB3_ENST00000311626.4_Silent_p.I422I|HOXB3_ENST00000498678.1_Silent_p.I422I|HOXB3_ENST00000476342.1_Silent_p.I422I|HOXB3_ENST00000472863.1_Silent_p.I349I|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Silent_p.I290I			P14651	HXB3_HUMAN	homeobox B3	422					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						GCGCTTCTTGGATTCTACCCT	0.617000											OREG0024516	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	44					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7866409	7866409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:7866409G>A	ENST00000378789.3	-	6	967	c.916C>T	c.(916-918)Ctt>Ttt	p.L306F		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	306	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						TTGGCGCCAAGAGCCAGAGCT	0.488000													63	185					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62442615	62442615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:62442615C>T	ENST00000281156.4	-	7	1143	c.865G>A	c.(865-867)Gat>Aat	p.D289N		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding	p.D289N(1)		NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TAGCTGTTATCATAAGTCTCA	0.378000													29	90					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3267076	3267076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3267076C>T	ENST00000520002.1	-	14	2171	c.1616G>A	c.(1615-1617)cGg>cAg	p.R539Q	CSMD1_ENST00000542608.1_Missense_Mutation_p.R538Q|CSMD1_ENST00000400186.3_Missense_Mutation_p.R539Q|CSMD1_ENST00000602557.1_Missense_Mutation_p.R539Q|CSMD1_ENST00000537824.1_Missense_Mutation_p.R538Q|CSMD1_ENST00000602723.1_Missense_Mutation_p.R539Q|CSMD1_ENST00000539096.1_Missense_Mutation_p.R538Q			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	539	Sushi 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTGCCCGTCCGCTTCCCATA	0.493000													3	15					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501704	90501704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90501704C>T	ENST00000325643.5	+	4	2368	c.2302C>T	c.(2302-2304)Cat>Tat	p.H768Y		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCTGCAAATCCATCTGGCCAG	0.552000													18	56					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595640	140595640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140595640G>A	ENST00000341948.4	+	1	2132	c.1945G>A	c.(1945-1947)Gag>Aag	p.E649K		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		649	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACAATGGCGAGCCTCCGCG	0.726000													26	54					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102737049	102737049	+	RNA	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102737049T>C	ENST00000532855.1	-	0	1137							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	GAATTACCTTTAAAAAGAAAA	0.318000													2	8					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135392938	135392938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:135392938C>T	ENST00000354042.4	-	3	978	c.289G>A	c.(289-291)Gct>Act	p.A97T	AC091736.10_ENST00000378428.3_RNA	NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4	97						integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						TCCACGGCAGCCGCCACGCAG	0.612000													37	207					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233270846	233270846	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233270846G>A	ENST00000258229.8	-	21	3984	c.3750C>T	c.(3748-3750)ttC>ttT	p.F1250F	PCNXL2_ENST00000520463.1_5'UTR|PCNXL2_ENST00000488780.2_Silent_p.F383F	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1250						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGATGACAGTGAAGCTCAAGT	0.393000													32	58					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15646284	15646284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15646284C>T	ENST00000378076.3	-	20	2394	c.2041G>A	c.(2041-2043)Gaa>Aaa	p.E681K		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	681					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TATGCTCCTTCCCCTTCATTT	0.358000													29	60					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179732833	179732833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179732833C>T	ENST00000420890.2	-	16	2611	c.2494G>A	c.(2494-2496)Gaa>Aaa	p.E832K	CCDC141_ENST00000295723.5_Missense_Mutation_p.E257K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	257							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GCTTGCTTTTCCTGAGAGCAC	0.517000													26	64					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106109697	106109697	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106109697G>A	ENST00000390545.2	-	0	823																											GTCCAGCATGGGAGGTGTGGT	0.587000													72	187					0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161130934	161130934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161130934C>T	ENST00000368002.3	+	3	881	c.504C>T	c.(502-504)acC>acT	p.T168T	USP21_ENST00000289865.8_Silent_p.T168T|USP21_ENST00000368001.1_Silent_p.T168T	NM_001014443.2	NP_001014443.1	Q9UK80	UBP21_HUMAN	ubiquitin specific peptidase 21	168					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GACCCCCTACCCTGTTCAGCA	0.607000													25	65					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28305321	28305321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:28305321G>A	ENST00000284987.5	-	5	1853	c.1732C>T	c.(1732-1734)Cag>Tag	p.Q578*	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	578	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						CGAGAACACTGGCCCCAGGAT	0.483000													9	30					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65489537	65489537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65489537G>A	ENST00000261883.4	-	9	3253	c.3087C>T	c.(3085-3087)ccC>ccT	p.P1029P		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	1029					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						AGCTGCCCTGGGGGATGACCT	0.582000													18	88					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113231680	113231680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113231680C>T	ENST00000369644.1	+	4	1122	c.93C>T	c.(91-93)ttC>ttT	p.F31F	MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000413052.2_Silent_p.F87F|MOV10_ENST00000369645.1_Silent_p.F87F|MOV10_ENST00000357443.2_Silent_p.F87F			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	87					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		ACGTGCGGTTCCCAGAAAAGA	0.498000													20	42					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41151040	41151040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41151040C>T	ENST00000380588.4	+	5	845	c.742C>T	c.(742-744)Cca>Tca	p.P248S	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	248						integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				TATTAATATTCCAGGTGTATT	0.408000													25	112					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40114658	40114658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40114658G>A	ENST00000324616.5	+	13	1718	c.1564G>A	c.(1564-1566)Gaa>Aaa	p.E522K		NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	522										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						CAAAACCAAGGAAAAAATGAA	0.294000													24	88					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17422449	17422449	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17422449C>T	ENST00000375486.4	-	4	429	c.366G>A	c.(364-366)gtG>gtA	p.V122V	PADI2_ENST00000375481.1_Silent_p.V122V|PADI2_ENST00000444885.2_Silent_p.V122V	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	122					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	GGTCTGCGTCCACATCCAGGG	0.602000													50	109					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3256994	3256994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3256994G>A	ENST00000520002.1	-	17	2882	c.2327C>T	c.(2326-2328)cCa>cTa	p.P776L	CSMD1_ENST00000542608.1_Missense_Mutation_p.P775L|CSMD1_ENST00000400186.3_Missense_Mutation_p.P776L|CSMD1_ENST00000602557.1_Missense_Mutation_p.P776L|CSMD1_ENST00000537824.1_Missense_Mutation_p.P775L|CSMD1_ENST00000602723.1_Missense_Mutation_p.P776L|CSMD1_ENST00000539096.1_Missense_Mutation_p.P775L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	776	CUB 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATAATATCCTGGCCATCCAGG	0.388000													19	52					0	0	1	0	0
HCAR3	8843	broad.mit.edu	37	12	123200717	123200717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123200717C>T	ENST00000528880.2	-	1	722	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	HCAR1_ENST00000356987.2_Intron	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	190						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	AACATAGCTTCGTGCCACCGG	0.537000													22	74					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135757541	135757541	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:135757541G>A	ENST00000375845.3	-	4	310	c.280C>T	c.(280-282)Caa>Taa	p.Q94*	MAP3K19_ENST00000392917.3_Nonsense_Mutation_p.Q94*|MAP3K19_ENST00000392918.3_Nonsense_Mutation_p.Q94*|MAP3K19_ENST00000375844.3_Nonsense_Mutation_p.Q94*|MAP3K19_ENST00000358371.4_Intron|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392915.1_Nonsense_Mutation_p.Q111*	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		CTCATTTCTTGGGGAGGACTG	0.363000													9	104					0	0	1	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622025	234622025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234622025G>A	ENST00000373414.3	+	1	388	c.388G>A	c.(388-390)Gag>Aag	p.E130K	UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000373445.1_Intron	NM_019078.1	NP_061951.1														cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GTCTTGTGTGGAGCTACTGCA	0.438000													58	221					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23522956	23522956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:23522956G>A	ENST00000296682.3	+	8	1026	c.844G>A	c.(844-846)Gaa>Aaa	p.E282K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	282	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CCGAATTACAGAAGACGAAGA	0.552000										HNSCC(3;0.000094)			30	104					0	0	1	0	0
MYCT1	80177	broad.mit.edu	37	6	153043320	153043320	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:153043320C>T	ENST00000367245.5	+	2	648	c.640C>T	c.(640-642)Cga>Tga	p.R214*	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	214						nucleus				NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TAACAGTCTTCGAGTGGGCCT	0.512000													36	45					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77316575	77316575	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:77316575G>A	ENST00000255194.6	-	25	3108	c.2933C>T	c.(2932-2934)cCt>cTt	p.P978L	AP3B1_ENST00000519295.1_Missense_Mutation_p.P929L|AP3B1_ENST00000523204.1_5'UTR	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	978					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TTCTCCAACAGGTGGCTGAAT	0.338000									Hermansky-Pudlak syndrome				23	61					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42693486	42693486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42693486C>T	ENST00000372999.1	+	7	1017	c.823C>T	c.(823-825)Ctc>Ttc	p.L275F	TOX2_ENST00000435864.2_Missense_Mutation_p.L195F|TOX2_ENST00000341197.3_Missense_Mutation_p.L317F|TOX2_ENST00000358131.5_Intron|TOX2_ENST00000423191.1_Missense_Mutation_p.L275F	NM_032883.2	NP_116272.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCGGGCTAGCCTCGTCTCCAA	0.582000													37	92					0	0	1	0	0
GALR1	2587	broad.mit.edu	37	18	74968155	74968155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74968155G>A	ENST00000299727.3	+	2	708	c.708G>A	c.(706-708)aaG>aaA	p.K236K	GALR1_ENST00000582943.1_3'UTR	NM_001480.3	NP_001471.2	P47211	GALR1_HUMAN	galanin receptor 1	236					digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		ACATGTCAAAGAAGTCTGAAG	0.348000													25	74					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108124267	108124267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108124267G>A	ENST00000273353.3	-	34	4770	c.4714C>T	c.(4714-4716)Cat>Tat	p.H1572Y		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1572						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AGCTGGAAATGAAGAATCTTG	0.318000													8	42					0	0	1	0	0
HAUS4	54930	broad.mit.edu	37	14	23416931	23416931	+	Missense_Mutation	SNP	G	G	A	rs138593865	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23416931G>A	ENST00000206474.7	-	8	970	c.718C>T	c.(718-720)Cgc>Tgc	p.R240C	RP11-298I3.1_ENST00000548819.1_RNA|HAUS4_ENST00000554446.1_5'UTR|HAUS4_ENST00000342454.8_Missense_Mutation_p.R195C|HAUS4_ENST00000555367.1_Missense_Mutation_p.R195C|HAUS4_ENST00000541587.1_Missense_Mutation_p.R240C|RP11-298I3.1_ENST00000548322.1_RNA|HAUS4_ENST00000490506.1_Missense_Mutation_p.R116C|RP11-298I3.5_ENST00000555074.1_Missense_Mutation_p.P69L|HAUS4_ENST00000555986.1_Missense_Mutation_p.R195C|HAUS4_ENST00000347758.2_Missense_Mutation_p.R114C|HAUS4_ENST00000397409.4_Missense_Mutation_p.R114C			Q9H6D7	HAUS4_HUMAN	HAUS augmin-like complex, subunit 4	240					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|cervix(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)	14						GTGAGGCAGCGGAGAAGCACC	0.507000													27	76					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233898898	233898898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233898898G>A	ENST00000233840.3	+	2	274	c.274G>A	c.(274-276)Gac>Aac	p.D92N		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	92							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CCCCTTGTATGACGCGCAGAC	0.617000													56	95					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28841284	28841284	+	Silent	SNP	C	C	T	rs145751891		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28841284C>T	ENST00000336783.4	+	8	1106	c.939C>T	c.(937-939)atC>atT	p.I313I	ATXN2L_ENST00000564304.1_Silent_p.I313I|ATXN2L_ENST00000395547.2_Silent_p.I313I|ATXN2L_ENST00000382686.4_Silent_p.I313I|ATXN2L_ENST00000340394.8_Silent_p.I313I|ATXN2L_ENST00000570200.1_Silent_p.I313I|ATXN2L_ENST00000325215.6_Silent_p.I313I	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	313						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						GCCTACGGATCGCCATGGAGA	0.602000													10	42					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46216600	46216600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46216600C>T	ENST00000371374.1	-	3	450	c.259G>A	c.(259-261)Gac>Aac	p.D87N	RCAN2_ENST00000330430.6_Missense_Mutation_p.D41N|RCAN2_ENST00000405162.1_Missense_Mutation_p.D87N|RCAN2_ENST00000306764.7_Missense_Mutation_p.D87N	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	41					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						GTCACACAGTCATCATAAGTC	0.418000													5	61					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47746586	47746586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47746586G>A	ENST00000273857.4	-	5	631	c.632C>T	c.(631-633)cCc>cTc	p.P211L	CORIN_ENST00000504584.1_Missense_Mutation_p.P211L|CORIN_ENST00000502252.1_Missense_Mutation_p.P144L|CORIN_ENST00000505909.1_Missense_Mutation_p.P211L|CORIN_ENST00000508498.1_Missense_Mutation_p.P72L	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	211	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GGACCTACAGGGCAGGAGTCC	0.413000													48	126					0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5340055	5340055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5340055C>T	ENST00000396872.2	+	10	1373	c.1212C>T	c.(1210-1212)atC>atT	p.I404I	SLC29A4_ENST00000406453.3_Silent_p.I390I|SLC29A4_ENST00000439491.2_3'UTR|SLC29A4_ENST00000297195.4_Silent_p.I404I	NM_001040661.1|NM_153247.2	NP_001035751.1|NP_694979.2	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4	404					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		CTCTGCAGATCCTGGCAGCCC	0.667000													22	52					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166408691	166408691	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:166408691G>A	ENST00000402744.4	+	6	1355	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	359					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GACCTACTGGGAGGATAACAA	0.443000													18	56					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157557700	157557700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157557700C>T	ENST00000271532.1	-	4	652	c.517G>A	c.(517-519)Gag>Aag	p.E173K	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	173	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				ACATCATTCTCGTCTCCATAT	0.318000													13	18					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793279	29793279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29793279G>A	ENST00000269202.6	+	11	1383	c.1336G>A	c.(1336-1338)Gga>Aga	p.G446R	MEP1B_ENST00000581447.1_Missense_Mutation_p.G446R	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	446	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						CAGCCCAAATGGAACTCTGTA	0.408000													13	26					0	0	1	0	0
SDC3	9672	broad.mit.edu	37	1	31350044	31350044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:31350044G>A	ENST00000336798.7	-	1	1543	c.51C>T	c.(49-51)tcC>tcT	p.S17S	SDC3_ENST00000471567.1_Intron|SDC3_ENST00000339394.6_Intron			O75056	SDC3_HUMAN	syndecan 3	349						integral to membrane	cytoskeletal protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGAGCTAGGGAGCTGGGTG	0.577000													3	20					0	0	1	0	0
ABO	28	broad.mit.edu	37	9	136131040	136131040	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136131040C>T	ENST00000453660.2	-	0	1088							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		CTCCCAGAGCCCCTGGCAGCC	0.652000													5	5					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64880832	64880832	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64880832G>A	ENST00000169565.3	+	4	624	c.624G>A	c.(622-624)ctG>ctA	p.L208L	CACNG5_ENST00000307139.3_Intron|CACNG5_ENST00000533854.1_Intron			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	0				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CTGCCCCACTGAGCCGGGGAG	0.582000													11	110					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121976229	121976229	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121976229C>T	ENST00000498619.1	+	3	925	c.487C>T	c.(487-489)Ccc>Tcc	p.P163S	CASR_ENST00000296154.5_Missense_Mutation_p.P163S|CASR_ENST00000490131.1_Missense_Mutation_p.P163S	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	163					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity	p.P163S(1)		NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTTCTACATTCCCCAGGTACT	0.567000													17	69					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63852307	63852307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:63852307C>T	ENST00000279873.7	+	10	3495	c.3085C>T	c.(3085-3087)Cgg>Tgg	p.R1029W	ARID5B_ENST00000309334.5_Missense_Mutation_p.R786W	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1029					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding	p.R1029W(1)		NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					GAAAAAGGCCCGGGCAGTGTC	0.597000													29	112					0	0	1	0	0
MEGF9	1955	broad.mit.edu	37	9	123476144	123476144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123476144G>A	ENST00000373930.3	-	1	604	c.493C>T	c.(493-495)Ccg>Tcg	p.P165S	MEGF9_ENST00000426959.1_Missense_Mutation_p.P157S	NM_001080497.2	NP_001073966.2	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	165	Pro-rich.					integral to membrane	calcium ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	16						GTGGGCGCCGGTACGGTGGTC	0.726000													15	26					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347431	48347431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48347431C>T	ENST00000319856.4	+	1	960	c.939C>T	c.(937-939)acC>acT	p.T313T		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						TCATTTATACCCTGAGAAATG	0.323000													13	59					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6239766	6239766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6239766C>T	ENST00000400104.3	-	9	858	c.658G>A	c.(658-660)Gat>Aat	p.D220N	L3MBTL4_ENST00000400105.2_Missense_Mutation_p.D220N|L3MBTL4_ENST00000535782.1_Missense_Mutation_p.D33N|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.D220N|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.D220N			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	220					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				AGTAAGCGATCTTCAACAATA	0.403000													13	110					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79747293	79747293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:79747293G>A	ENST00000261205.4	+	9	1479	c.822G>A	c.(820-822)ttG>ttA	p.L274L	SYT1_ENST00000552744.1_Silent_p.L274L|SYT1_ENST00000393240.3_Silent_p.L274L|SYT1_ENST00000457153.2_Silent_p.L271L	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	274	Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						AAGAGAAATTGGGTGATATCT	0.373000													63	120					0	0	1	0	0
S100A3	6274	broad.mit.edu	37	1	153520173	153520173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153520173G>A	ENST00000368713.3	-	3	487	c.291C>T	c.(289-291)ccC>ccT	p.P97P	S100A3_ENST00000368712.1_Silent_p.P97P|S100A4_ENST00000368714.1_Intron	NM_002960.1	NP_002951.1	P33764	S10A3_HUMAN	S100 calcium binding protein A3	97							calcium ion binding|protein binding			breast(1)|liver(1)|lung(1)	3	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGAGCAGGGGGGCTCTGAGG	0.622000													17	91					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101844953	101844953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101844953C>T	ENST00000360264.3	+	18	2429	c.2409C>T	c.(2407-2409)ccC>ccT	p.P803P	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292535.7_Silent_p.P792P|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000556210.1_Silent_p.P634P|CUX1_ENST00000550008.2_Silent_p.P736P|CUX1_ENST00000549414.2_Silent_p.P770P|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Silent_p.P690P	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	792					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						AGGACGCCCCCGGGCTGGACC	0.667000													20	39					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378681	114378681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:114378681C>T	ENST00000312719.5	-	5	1969	c.781G>A	c.(781-783)Gaa>Aaa	p.E261K	HS3ST5_ENST00000411826.1_Missense_Mutation_p.E261K|RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000523087.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	261					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GGCAGAGGTTCCGTGATGAGG	0.433000													22	43					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29194715	29194715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:29194715G>A	ENST00000240100.2	-	4	1402	c.1013C>T	c.(1012-1014)tCc>tTc	p.S338F	DUSP4_ENST00000240101.2_Missense_Mutation_p.S247F	NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	338	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		CGCAGCACAGGACGTGGCCAG	0.662000													9	26					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41323603	41323603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41323603C>T	ENST00000551295.2	+	7	619	c.502C>T	c.(502-504)Ctt>Ttt	p.L168F	CNTN1_ENST00000547849.1_Missense_Mutation_p.L168F|CNTN1_ENST00000547702.1_Missense_Mutation_p.L168F|CNTN1_ENST00000348761.2_Missense_Mutation_p.L157F|CNTN1_ENST00000360099.3_Missense_Mutation_p.L168F|CNTN1_ENST00000347616.1_Missense_Mutation_p.L168F	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	168	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CCTAGATGATCTTAGCTATCG	0.338000													8	49					0	0	1	0	0
VGLL1	51442	broad.mit.edu	37	X	135618348	135618348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135618348G>A	ENST00000370634.3	+	2	339	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					GAGCCCCCAGGAATTGACCCC	0.537000													36	20					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664162	44664162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44664162G>A	ENST00000454036.1	+	3	412	c.336G>A	c.(334-336)aaG>aaA	p.K112K	SLC12A5_ENST00000243964.3_Silent_p.K89K|SLC12A5_ENST00000539566.1_Silent_p.K89K|SLC12A5_ENST00000372315.1_Silent_p.K89K	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	112					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTGGAAAAAAGAAGCCGGTGC	0.557000													18	42					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67283854	67283854	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67283854G>A	ENST00000392676.3	-	15	2005	c.1941C>T	c.(1939-1941)ccC>ccT	p.P647P	ABCA5_ENST00000588877.1_Silent_p.P647P|ABCA5_ENST00000392677.2_Silent_p.P647P			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	647	ABC transporter 1.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					GTCGAGAACAGGGGTCCATTC	0.413000													45	96					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44415559	44415559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44415559C>T	ENST00000372343.3	+	2	1217	c.555C>T	c.(553-555)taC>taT	p.Y185Y		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	185					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TACCCCAGTACCGCAAAGGCC	0.647000													6	16					0	0	1	0	0
MIR7162	102466227	broad.mit.edu	37	15	62539564	62539564	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:62539564C>T	ENST00000570077.1	-	0	218																											TGCAGATACTCGGCATACTGC	0.542000													13	28					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20329750	20329750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20329750G>A	ENST00000302555.5	-	7	1159	c.1010C>T	c.(1009-1011)tCc>tTc	p.S337F	GP2_ENST00000341642.5_Missense_Mutation_p.S190F|GP2_ENST00000381360.5_Missense_Mutation_p.S193F|GP2_ENST00000381362.4_Missense_Mutation_p.S340F|GP2_ENST00000573897.1_5'UTR			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	340	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GACGTTCAGGGAACTGAGAAA	0.468000													37	95					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467212	10467212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10467212C>T	ENST00000382483.3	-	4	4619	c.4396G>A	c.(4396-4398)Gag>Aag	p.E1466K		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1466					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTCTGCCTCTCGCTGGCACTT	0.657000													40	78					0	0	1	0	0
CLDN3	1365	broad.mit.edu	37	7	73184326	73184326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73184326C>T	ENST00000395145.2	-	1	274	c.54G>A	c.(52-54)ctG>ctA	p.L18L		NM_001306.3	NP_001297.1	O15551	CLD3_HUMAN	claudin 3	18					response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity			kidney(1)|lung(1)	2		Lung NSC(55;0.159)				CGATGGTGCCCAGCCAGCCCA	0.692000													10	18					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136568062	136568062	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136568062G>A	ENST00000371872.4	-	13	1901	c.1644C>T	c.(1642-1644)ttC>ttT	p.F548F	SARDH_ENST00000371868.1_5'UTR|SARDH_ENST00000422262.2_Silent_p.F380F|SARDH_ENST00000439388.1_Silent_p.F548F	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	548					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GCGGGAAGGCGAAGGTGTACT	0.662000													4	14					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135431120	135431120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135431120C>T	ENST00000394143.1	+	6	5546	c.5255C>T	c.(5254-5256)tCa>tTa	p.S1752L	GPR112_ENST00000370652.1_Missense_Mutation_p.S1752L|GPR112_ENST00000394141.1_Missense_Mutation_p.S1547L|GPR112_ENST00000412101.1_Missense_Mutation_p.S1547L|GPR112_ENST00000287534.4_Missense_Mutation_p.S1689L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1752					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AATATGCTTTCACCTACTCAT	0.413000													50	76					0	0	1	0	0
C16orf92	146378	broad.mit.edu	37	16	30035190	30035190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30035190C>T	ENST00000300575.2	+	2	294	c.273C>T	c.(271-273)atC>atT	p.I91I		NM_001109659.1|NM_001109660.1	NP_001103129.1|NP_001103130.1	Q96LL3	CP092_HUMAN	chromosome 16 open reading frame 92	91						integral to membrane				breast(3)|lung(3)	6						AGAAACCCATCGTGTTCATTA	0.557000													5	43					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513721	78513721	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:78513721C>T	ENST00000397909.2	+	15	3918	c.3745C>T	c.(3745-3747)Cga>Tga	p.R1249*	NAV3_ENST00000228327.6_Nonsense_Mutation_p.R1249*|NAV3_ENST00000536525.2_Nonsense_Mutation_p.R1249*|NAV3_ENST00000266692.7_Nonsense_Mutation_p.R1249*			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1249	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACCCACATTTCGAAGGTAAGG	0.403000										HNSCC(70;0.22)			7	54					0	0	1	0	0
CAMKK1	84254	broad.mit.edu	37	17	3772812	3772812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3772812G>A	ENST00000381771.2	-	15	1571	c.1424C>T	c.(1423-1425)tCa>tTa	p.S475L	CAMKK1_ENST00000381769.2_Missense_Mutation_p.S464L|CAMKK1_ENST00000158166.5_Missense_Mutation_p.S475L|CAMKK1_ENST00000348335.2_Missense_Mutation_p.S437L			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	437					synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		GAGCCTGACTGAGTTCTTAAC	0.622000													18	56					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785469	134785469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134785469G>A	ENST00000537858.1	-	2	361	c.161C>T	c.(160-162)tCc>tTc	p.S54F		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	54	FHA.									breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTGACGGCGGGAGAGGCGAGG	0.657000													6	64					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11738216	11738216	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11738216G>A	ENST00000262442.3	+	49	9575		c.e49+1		DNAH9_ENST00000454412.2_Splice_Site	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCTGAACAAGGTAGGAGGACT	0.562000													6	7					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47981665	47981665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47981665C>T	ENST00000318711.7	+	34	4222	c.4039C>T	c.(4039-4041)Cgt>Tgt	p.R1347C	DIP2A_ENST00000400274.1_Missense_Mutation_p.R1342C|DIP2A_ENST00000417564.2_Missense_Mutation_p.R1346C	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	1346					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TTTTAGGGTTCGTTTGGTAGA	0.458000													33	130					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262462	140262462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140262462G>A	ENST00000289272.2	+	1	609	c.609G>A	c.(607-609)gaG>gaA	p.E203E	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.E203E|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACAGAGAGGAAATTCAGG	0.448000													8	98					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95947900	95947900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95947900G>A	ENST00000317620.9	+	14	1787	c.1654G>A	c.(1654-1656)Gaa>Aaa	p.E552K	PROM2_ENST00000542147.1_Missense_Mutation_p.E552K|PROM2_ENST00000317668.4_Missense_Mutation_p.E552K|PROM2_ENST00000403131.2_Missense_Mutation_p.E552K	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	552						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						GCAGTGCAAGGAAGGGGCAGC	0.612000													9	24					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157667561	157667561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157667561G>A	ENST00000368184.3	-	5	738	c.447C>T	c.(445-447)atC>atT	p.I149I	FCRL3_ENST00000368186.5_Silent_p.I149I|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	149	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity	p.I149I(1)		autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AATTCACTGTGATCTTCTCTA	0.338000													51	118					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60184221	60184221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60184221G>A	ENST00000300187.6	+	5	2057	c.1780G>A	c.(1780-1782)Gag>Aag	p.E594K	MS4A14_ENST00000395005.2_Missense_Mutation_p.E577K|MS4A14_ENST00000531783.1_Missense_Mutation_p.E627K|MS4A14_ENST00000531787.1_Missense_Mutation_p.E482K	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	594	Gln-rich.					integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						GACTGATAAGGAGCAAAACTC	0.463000													14	33					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21992264	21992264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21992264C>T	ENST00000327430.3	-	2	1892	c.1598G>A	c.(1597-1599)gGc>gAc	p.G533D	SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron|SALL2_ENST00000450879.2_Missense_Mutation_p.G396D	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	533							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GATGGCTGAGCCCTCACTCCC	0.522000													7	66					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420498	55420498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55420498C>T	ENST00000242994.3	+	2	653	c.275C>T	c.(274-276)gCt>gTt	p.A92V		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	92					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						AGAGTCAAGGCTAATGCCAGA	0.502000													22	76					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114380799	114380799	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114380799G>A	ENST00000359785.5	-	13	1358	c.1223C>T	c.(1222-1224)cCt>cTt	p.P408L	PTPN22_ENST00000528414.1_Missense_Mutation_p.P353L|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000420377.2_Missense_Mutation_p.P408L|PTPN22_ENST00000525799.1_Missense_Mutation_p.P281L|PTPN22_ENST00000538253.1_Missense_Mutation_p.P164L	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	408					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCTGAAGAGGCTCCCCAAC	0.378000													6	99					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11450874	11450874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:11450874C>T	ENST00000423059.3	-	19	4009	c.3758G>A	c.(3757-3759)cGa>cAa	p.R1253Q	AC004538.3_ENST00000445839.1_RNA|AC004160.4_ENST00000425837.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1253	TSP type-1 12.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GCCATCACTTCGAACACAATC	0.403000										HNSCC(18;0.044)			20	48					0	0	1	0	0
C16orf82	162083	broad.mit.edu	37	16	27078298	27078298	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27078298C>T	ENST00000505035.1	+	0	271				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			ATTCAGAGGCCTCCCAGGGCC	0.547000													21	50					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186266028	186266028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186266028C>T	ENST00000445192.2	+	2	66	c.21C>T	c.(19-21)ccC>ccT	p.P7P	PRG4_ENST00000367483.4_Silent_p.P7P|PRG4_ENST00000367484.3_Silent_p.P7P|PRG4_ENST00000367485.4_Silent_p.P7P|PRG4_ENST00000367486.3_Silent_p.P7P	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	7					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						AAACACTTCCCATTTACCTGT	0.373000													21	44					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49168441	49168441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49168441C>T	ENST00000340334.7	-	20	2443	c.2075G>A	c.(2074-2076)gGa>gAa	p.G692E	FOLH1_ENST00000256999.2_Missense_Mutation_p.G707E|FOLH1_ENST00000343844.4_Missense_Mutation_p.G399E|FOLH1_ENST00000533034.1_Missense_Mutation_p.G661E|FOLH1_ENST00000356696.3_Missense_Mutation_p.G676E	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	707					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ATCATAAATTCCTGGGAATGA	0.443000													44	62					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88429746	88429746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:88429746G>A	ENST00000261304.2	-	10	1249	c.1143C>T	c.(1141-1143)acC>acT	p.T381T	GALC_ENST00000544807.2_Silent_p.T325T|GALC_ENST00000393568.4_Silent_p.T358T|GALC_ENST00000393569.2_Silent_p.T355T	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	381					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CAATGATGATGGTGAGGTTCC	0.368000													32	101					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162729659	162729659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:162729659C>T	ENST00000367922.2	+	9	1183	c.745C>T	c.(745-747)Cac>Tac	p.H249Y	DDR2_ENST00000367921.3_Missense_Mutation_p.H249Y	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	249					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CCATGAATACCACGTGTGGCC	0.532000													17	77					0	0	1	0	0
MIR99AHG	388815	broad.mit.edu	37	21	17912223	17912223	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:17912223C>T	ENST00000458468.1	+	0	579				MIRLET7C_ENST00000362160.1_RNA	NR_027790.1																						TTCTAGCTTTCCTTGGAGCAC	0.438000													15	70					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76556101	76556101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:76556101C>T	ENST00000307431.8	+	18	3084	c.2699C>T	c.(2698-2700)cCc>cTc	p.P900L	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.P828L|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.P852L|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.P904L|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	901	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AAGACACAGCCCGCCCCCGCT	0.493000													8	75					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41564759	41564759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41564759C>T	ENST00000263253.7	+	25	5279	c.4060C>T	c.(4060-4062)Cca>Tca	p.P1354S		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1354					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						AGAATCCTTTCCATACCGAAC	0.458000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				21	87					0	0	1	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24524132	24524132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:24524132C>T	ENST00000376862.3	+	2	1032	c.399C>T	c.(397-399)ttC>ttT	p.F133F		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	133					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						ATGGGAAGTTCATTGACCTCT	0.587000													51	117					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21739650	21739650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21739650C>T	ENST00000388958.3	+	19	2106	c.2105C>T	c.(2104-2106)tCc>tTc	p.S702F	OTOA_ENST00000388956.4_Missense_Mutation_p.S623F|OTOA_ENST00000388957.3_Missense_Mutation_p.S378F|OTOA_ENST00000286149.4_Missense_Mutation_p.S716F	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	716					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		AGGGGGATCTCCCCCAGGGCT	0.577000													18	54					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427572	135427572	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135427572G>A	ENST00000394143.1	+	6	1998	c.1707G>A	c.(1705-1707)gaG>gaA	p.E569E	GPR112_ENST00000370652.1_Silent_p.E569E|GPR112_ENST00000394141.1_Silent_p.E364E|GPR112_ENST00000412101.1_Silent_p.E364E|GPR112_ENST00000287534.4_Silent_p.E506E	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	569					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTGGGACTGAGAGTGTACAGA	0.428000													29	36					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181620505	181620505	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181620505G>A	ENST00000526775.1	+	7	1148	c.983G>A	c.(982-984)tGg>tAg	p.W328*	CACNA1E_ENST00000367570.1_Nonsense_Mutation_p.W328*|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000360108.3_Nonsense_Mutation_p.W328*|CACNA1E_ENST00000357570.5_Nonsense_Mutation_p.W279*|CACNA1E_ENST00000358338.5_Nonsense_Mutation_p.W279*|CACNA1E_ENST00000367573.2_Nonsense_Mutation_p.W328*	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	328					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.W328L(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ACCTGGAATTGGCTGTACTTC	0.428000													28	84					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152423746	152423746	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152423746C>T	ENST00000427231.2	-	114	18294	c.18092G>A	c.(18091-18093)tGg>tAg	p.W6031*	NEB_ENST00000604864.1_Nonsense_Mutation_p.W6031*|NEB_ENST00000603639.1_Nonsense_Mutation_p.W6031*|NEB_ENST00000172853.10_Nonsense_Mutation_p.W4330*|NEB_ENST00000397345.3_Nonsense_Mutation_p.W6031*|NEB_ENST00000409198.1_Nonsense_Mutation_p.W4330*	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	6028					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATGACACATCCATTGGTGCAA	0.428000													36	88					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1906950	1906950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1906950G>A	ENST00000399161.2	-	14	2681	c.1934C>T	c.(1933-1935)tCg>tTg	p.S645L	MYT1L_ENST00000428368.2_Missense_Mutation_p.S643L	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	645					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GTATTCAAACGAGGTCTTGGA	0.483000													27	59					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160802361	160802361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160802361C>T	ENST00000368034.4	-	8	1142	c.965G>A	c.(964-966)gGa>gAa	p.G322E	CD244_ENST00000368033.3_Missense_Mutation_p.G327E|CD244_ENST00000481677.1_5'UTR|CD244_ENST00000322302.7_Missense_Mutation_p.G230E	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	327					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTTCCTGGATCCAGACTAGAA	0.458000													24	57					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455093	84455093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:84455093G>A	ENST00000377084.2	-	1	1435	c.550C>T	c.(550-552)Ctc>Ttc	p.L184F		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	184						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTACCCCGGAGGTCGAGGTGG	0.532000													33	70					0	0	1	0	0
C19orf59	199675	broad.mit.edu	37	19	7742573	7742573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7742573G>A	ENST00000333598.3	+	2	599	c.145G>A	c.(145-147)Gac>Aac	p.D49N	C19orf59_ENST00000597445.1_Intron	NM_174918.2	NP_777578.2	Q8IX19	MCEM1_HUMAN	chromosome 19 open reading frame 59	49						integral to membrane				endometrium(1)|lung(2)|skin(1)|stomach(1)	5						CAAAAATCAGGACCATGCAAA	0.567000											OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	49					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44669131	44669131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44669131G>A	ENST00000454036.1	+	7	877	c.801G>A	c.(799-801)gtG>gtA	p.V267V	SLC12A5_ENST00000243964.3_Silent_p.V244V|SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000372315.1_Silent_p.V244V	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	267					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGGCCACTGTGGTGTTTGTGG	0.537000													23	44					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42236191	42236191	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42236191G>A	ENST00000541110.1	-	5	1706	c.1138C>T	c.(1138-1140)Cag>Tag	p.Q380*	TRERF1_ENST00000340840.2_Nonsense_Mutation_p.Q380*|TRERF1_ENST00000354325.2_Nonsense_Mutation_p.Q380*|TRERF1_ENST00000372917.4_Nonsense_Mutation_p.Q380*|TRERF1_ENST00000372922.4_Nonsense_Mutation_p.Q380*			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	380	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGGGGCTCCTGGTAGTAGTAC	0.597000													28	105					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488791	20488791	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20488791C>T	ENST00000555186.1	+	0	274					NR_038836.1																						AGAGACCTCTCTCATGAGAAC	0.413000													21	113					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26697485	26697485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26697485C>T	ENST00000272371.2	-	26	3310	c.3184G>A	c.(3184-3186)Gag>Aag	p.E1062K	OTOF_ENST00000403946.3_Missense_Mutation_p.E1062K|OTOF_ENST00000338581.6_Missense_Mutation_p.E315K|OTOF_ENST00000402415.3_Missense_Mutation_p.E372K|OTOF_ENST00000339598.3_Missense_Mutation_p.E315K	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1062					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGTACGCCTCGTCTGCCATC	0.612000													15	40					0	0	1	0	0
FGF6	2251	broad.mit.edu	37	12	4553315	4553315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4553315C>T	ENST00000228837.2	-	2	477	c.434G>A	c.(433-435)gGa>gAa	p.G145E		NM_020996.1	NP_066276.2	P10767	FGF6_HUMAN	fibroblast growth factor 6	145					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			GTACAATCTTCCTTTACTGTT	0.488000													17	38					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298450	107298450	+	Silent	SNP	G	G	A	rs138480673	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107298450G>A	ENST00000374781.2	-	1	687	c.645C>T	c.(643-645)ctC>ctT	p.L215L		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						AGGCCAGCTTGAGGACAGCTA	0.388000													33	119					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24185163	24185163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:24185163C>T	ENST00000396671.2	-	8	915	c.567G>A	c.(565-567)agG>agA	p.R189R	THRB_ENST00000280696.5_Silent_p.R204R|THRB_ENST00000356447.4_Silent_p.R189R|THRB_ENST00000416420.1_Silent_p.R189R	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	189					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	CTATCAGCTTCCTCTTGGCCA	0.562000													25	66					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158644199	158644199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158644199C>T	ENST00000368148.3	-	10	1450	c.1270G>A	c.(1270-1272)Gac>Aac	p.D424N	SPTA1_ENST00000368147.3_Missense_Mutation_p.D424N	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	424					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGAAATCGGTCATCGTAAGAG	0.448000													72	170					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38185201	38185201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38185201C>T	ENST00000373048.4	-	15	2640	c.2641G>A	c.(2641-2643)Gac>Aac	p.D881N	EPHA10_ENST00000540011.1_3'UTR|EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000330210.7_Missense_Mutation_p.D376N|EPHA10_ENST00000427468.2_Missense_Mutation_p.D881N	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	881	Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGCCAGCAGTCGAGCATTAGT	0.632000													9	50					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7909971	7909971	+	Silent	SNP	G	G	A	rs56056557		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7909971G>A	ENST00000254854.4	+	4	1467	c.1317G>A	c.(1315-1317)ggG>ggA	p.G439G		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	439					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TCCCGCGTGGGGGATCAGCAC	0.652000													3	12					0	0	1	0	0
ABHD15	116236	broad.mit.edu	37	17	27889807	27889807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:27889807G>A	ENST00000307201.4	-	2	1349	c.1179C>T	c.(1177-1179)ggC>ggT	p.G393G	RP11-68I3.2_ENST00000581474.1_RNA	NM_198147.2	NP_937790.2	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15	393						extracellular region	carboxylesterase activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	10						GGCGCAGGAAGCCACAGTGGC	0.592000													28	34					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729931	18729931	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18729931C>T	ENST00000440756.2	-	3	545	c.443G>A	c.(442-444)gGa>gAa	p.G148E	PSD3_ENST00000327040.8_Missense_Mutation_p.G148E|PSD3_ENST00000523619.1_Missense_Mutation_p.G83E			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	148					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTGTAATGTTCCGGAAATGAT	0.453000													21	154					0	0	1	0	0
HINFP	25988	broad.mit.edu	37	11	119003883	119003883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119003883C>T	ENST00000350777.2	+	9	1156	c.1093C>T	c.(1093-1095)Cgc>Tgc	p.R365C	HINFP_ENST00000527410.1_Missense_Mutation_p.R365C	NM_001243259.1|NM_015517.4|NM_198971.2	NP_001230188.1|NP_056332.2|NP_945322.1	Q9BQA5	HINFP_HUMAN	histone H4 transcription factor	365					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						CGTGCACCTTCGCAAGAAGCA	0.502000													42	139					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53241751	53241751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53241751C>T	ENST00000359499.4	-	2	220	c.209G>A	c.(208-210)cGa>cAa	p.R70Q	KRT78_ENST00000304620.4_Missense_Mutation_p.R180Q			Q8N1N4	K2C78_HUMAN	keratin 78	180	Gly-rich.|Head.					keratin filament	protein binding|structural molecule activity	p.R180L(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						CAGAGCCCCTCGTTCTCCCTG	0.607000													8	58					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819304	43819304	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43819304G>A	ENST00000382031.1	+	5	6378	c.6347G>A	c.(6346-6348)tGg>tAg	p.W2116*	MAP1A_ENST00000399453.1_Nonsense_Mutation_p.W1878*|MAP1A_ENST00000300231.5_Nonsense_Mutation_p.W1878*			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1878						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCCTTCTCTTGGGGCACAGCC	0.657000													13	34					0	0	1	0	0
CPPED1	55313	broad.mit.edu	37	16	12798716	12798716	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:12798716G>A	ENST00000381774.4	-	3	720	c.480C>T	c.(478-480)ttC>ttT	p.F160F	CPPED1_ENST00000261660.4_Intron|CPPED1_ENST00000433677.2_Intron	NM_018340.2	NP_060810.2	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain containing 1	160							hydrolase activity|metal ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						TGAGGACCAGGAACAGGACGC	0.617000													14	43					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35779419	35779419	+	Missense_Mutation	SNP	G	G	A	rs77036027	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35779419G>A	ENST00000440995.2	+	30	4403	c.4403G>A	c.(4402-4404)cGa>cAa	p.R1468Q	SPEF2_ENST00000356031.3_Missense_Mutation_p.R1473Q|SPEF2_ENST00000303129.4_5'UTR|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1473					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GACAGTCTTCGAGATCAGTTC	0.398000													11	83					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39159484	39159484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39159484C>T	ENST00000359534.3	-	5	1020	c.682G>A	c.(682-684)Gag>Aag	p.E228K		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	228					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						ATCCAGAGCTCCACGAAGTAG	0.577000													98	57					0	0	1	0	0
DYRK1A	1859	broad.mit.edu	37	21	38877616	38877616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38877616C>T	ENST00000339659.3	+	9	2713	c.1243C>T	c.(1243-1245)Cat>Tat	p.H415Y	DYRK1A_ENST00000338785.3_Missense_Mutation_p.H424Y|DYRK1A_ENST00000451934.1_Missense_Mutation_p.H424Y|DYRK1A_ENST00000398960.2_Missense_Mutation_p.H424Y|DYRK1A_ENST00000398956.2_Missense_Mutation_p.H424Y|DYRK1A_ENST00000321219.8_Missense_Mutation_p.H424Y|DYRK1A_ENST00000455387.2_Missense_Mutation_p.H196Y	NM_130436.2	NP_569120.1	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	424	Protein kinase.		Y -> F.		nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			breast(4)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						CCGTAAACTTCATAACATTCT	0.438000													36	55					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43327114	43327114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43327114G>A	ENST00000380486.3	-	10	1546	c.1305C>T	c.(1303-1305)tcC>tcT	p.S435S	C2CD2_ENST00000329623.7_Silent_p.S280S	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	435						cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						AGCTCAGCGGGGACGCCCTCC	0.582000													10	59					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685370	100685370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100685370C>T	ENST00000306151.4	+	3	10737	c.10673C>T	c.(10672-10674)cCa>cTa	p.P3558L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3558	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGTTCATCTCCAGCAACTCTT	0.478000													45	399					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106543539	106543539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:106543539G>A	ENST00000369096.4	+	3	575	c.341G>A	c.(340-342)gGa>gAa	p.G114E	PRDM1_ENST00000369091.2_Missense_Mutation_p.G78E	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	114	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACACGTTTTGGACCCCTAATA	0.368000			"""D, N, Mis, F, S"""		DLBCL								34	31					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238722307	238722307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238722307G>A	ENST00000316997.4	+	2	190	c.58G>A	c.(58-60)Gga>Aga	p.G20R	RBM44_ENST00000444524.2_3'UTR|RBM44_ENST00000409864.1_Missense_Mutation_p.G20R	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	19							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		CCACAGTAATGGAGGCAACCT	0.423000													16	47					0	0	1	0	0
AMN1	196394	broad.mit.edu	37	12	31850770	31850770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:31850770G>A	ENST00000281471.6	-	4	603	c.438C>T	c.(436-438)atC>atT	p.I146I	AMN1_ENST00000537562.1_Silent_p.I128I|AMN1_ENST00000542781.1_5'UTR|AMN1_ENST00000536761.1_Silent_p.I128I|AMN1_ENST00000541931.1_5'UTR	NM_001113402.1|NM_001278411.1|NM_001278412.1	NP_001106873.1|NP_001265340.1|NP_001265341.1	Q8IY45	AMN1_HUMAN	antagonist of mitotic exit network 1 homolog (S. cerevisiae)	146										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	7	all_cancers(9;7.41e-12)|all_epithelial(9;1.18e-11)|all_lung(12;1.14e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.162)		OV - Ovarian serous cystadenocarcinoma(6;0.0014)			CACCTAAATCGATGATCTTTA	0.423000													16	108					0	0	1	0	0
STEAP1B	256227	broad.mit.edu	37	7	22533207	22533207	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:22533207G>A	ENST00000404369.4	-	3	748	c.333C>T	c.(331-333)atC>atT	p.I111I	STEAP1B_ENST00000406890.2_Silent_p.I92I	NM_001164460.1	NP_001157932.1	Q6NZ63	STEAL_HUMAN	STEAP family member 1B	92						integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			endometrium(1)|kidney(1)|lung(2)	4						TGATGACCAGGATTGGAATTT	0.393000													19	97					0	0	1	0	0
IL36RN	26525	broad.mit.edu	37	2	113818501	113818501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113818501G>A	ENST00000393200.2	+	3	263	c.102G>A	c.(100-102)ggG>ggA	p.G34G	IL36RN_ENST00000346807.3_Silent_p.G34G	NM_012275.2	NP_036407.1	Q9UBH0	I36RA_HUMAN	interleukin 36 receptor antagonist	34						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						TGCATGCAGGGAAGGTCATTA	0.483000													11	43					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143960599	143960599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143960599C>T	ENST00000292427.4	-	2	276	c.244G>A	c.(244-246)Gac>Aac	p.D82N	CYP11B1_ENST00000517471.1_Missense_Mutation_p.D82N|CYP11B1_ENST00000377675.3_Missense_Mutation_p.D127N	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	82					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CCTCCCAAGTCGTACCTGTGG	0.637000									Familial Hyperaldosteronism type I				31	61					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91444808	91444808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91444808G>A	ENST00000261991.3	-	3	409	c.236C>T	c.(235-237)gCc>gTc	p.A79V	RPS6KA5_ENST00000418736.2_Missense_Mutation_p.A79V|RPS6KA5_ENST00000536315.2_5'UTR	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	79	Protein kinase 1.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		AACTTTCATGGCATACAGCTT	0.363000													21	52					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13762864	13762864	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13762864G>A	ENST00000265104.4	-	60	10352	c.10248C>T	c.(10246-10248)ttC>ttT	p.F3416F	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3416	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTATAGAAAAGAAGGAAGCCA	0.478000									Kartagener syndrome				24	70					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35709163	35709163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35709163G>A	ENST00000440995.2	+	19	2764	c.2764G>A	c.(2764-2766)Gaa>Aaa	p.E922K	SPEF2_ENST00000356031.3_Missense_Mutation_p.E927K|SPEF2_ENST00000509059.1_Missense_Mutation_p.E922K|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	927					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAAAGAGAAGGAAATTCATCA	0.428000													8	99					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111785346	111785346	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111785346G>A	ENST00000261726.6	+	22	3832	c.3678G>A	c.(3676-3678)gaG>gaA	p.E1226E		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1226						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TGCGCCGGGAGATGTTGGTGG	0.652000													36	128					0	0	1	0	0
C8orf4	56892	broad.mit.edu	37	8	40011025	40011025	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:40011025G>A	ENST00000315792.3	+	0	37					NM_020130.4	NP_064515.1	Q9NR00	CH004_HUMAN	chromosome 8 open reading frame 4						apoptosis					breast(1)|large_intestine(1)|ovary(1)	3	Ovarian(28;0.0173)	all_cancers(7;5.34e-21)|all_epithelial(6;1.04e-14)|Lung NSC(58;9.35e-06)|all_lung(54;1.39e-05)|Hepatocellular(245;0.00745)|Breast(189;0.0334)|Colorectal(162;0.0815)|Myeloproliferative disorder(644;0.116)|Esophageal squamous(32;0.141)	LUSC - Lung squamous cell carcinoma(45;0.000149)	KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		AAGCCTGGGAGCTGAATTCCG	0.493000													4	38					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39678528	39678528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39678528C>T	ENST00000265708.4	-	6	609	c.506G>A	c.(505-507)aGc>aAc	p.S169N	ADAM2_ENST00000523181.1_5'UTR|ADAM2_ENST00000379853.2_Missense_Mutation_p.S169N|ADAM2_ENST00000347580.4_Missense_Mutation_p.S169N|ADAM2_ENST00000521880.1_Missense_Mutation_p.S169N	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	169					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TACCTCTACGCTTTGTAATTT	0.294000													31	75					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205273430	205273430	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205273430C>T	ENST00000367157.3	-	7	1161	c.1035G>A	c.(1033-1035)gaG>gaA	p.E345E		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	345					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TGGCCCCATTCTCCAGGAGGG	0.667000													20	27					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34526853	34526853	+	Silent	SNP	C	C	T	rs17347322	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34526853C>T	ENST00000374012.3	+	16	2664	c.2535C>T	c.(2533-2535)cgC>cgT	p.R845R	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	845					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					AGAAGCCCCGCGCCTATTACC	0.632000													4	51					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54777751	54777751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54777751G>A	ENST00000218436.6	-	12	3444	c.3415C>T	c.(3415-3417)Cgc>Tgc	p.R1139C		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1139					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										AAGTAGGTGCGAGTCTGGTCC	0.592000													20	25					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167815251	167815251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167815251G>A	ENST00000367848.1	-	20	2909	c.2412C>T	c.(2410-2412)tcC>tcT	p.S804S	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.S896S|ADCY10_ENST00000545172.1_Silent_p.S743S			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	896					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TCAGAGACAAGGAACGATAGT	0.453000													11	99					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200957930	200957930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200957930G>A	ENST00000332129.2	-	22	3578	c.3262C>T	c.(3262-3264)Ccc>Tcc	p.P1088S	KIF21B_ENST00000360529.5_Missense_Mutation_p.P1088S|KIF21B_ENST00000461742.2_Missense_Mutation_p.P1088S|KIF21B_ENST00000422435.2_Missense_Mutation_p.P1088S	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1088					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TGCAGCTCGGGGTGAGCTTCA	0.627000													12	30					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64591999	64591999	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64591999G>A	ENST00000342711.5	-	37	4601	c.4602C>T	c.(4600-4602)gtC>gtT	p.V1534V		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1534					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GCCGTTCTGAGACCTGCAGGA	0.577000													9	56					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43034198	43034198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43034198G>A	ENST00000394056.2	+	6	1221	c.726G>A	c.(724-726)gaG>gaA	p.E242E	KLC4_ENST00000479388.1_Silent_p.E242E|KLC4_ENST00000259708.3_Silent_p.E260E|KLC4_ENST00000394058.1_Silent_p.E242E|KLC4_ENST00000458460.2_Silent_p.E242E|KLC4_ENST00000453940.2_Silent_p.E165E|KLC4_ENST00000347162.5_Silent_p.E242E			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	242						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			AGGACCTGGAGCGCACATCAG	0.592000													18	70					0	0	1	0	0
LGALS17A	400696	broad.mit.edu	37	19	40172135	40172135	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40172135G>A	ENST00000412609.1	+	0	124																											CAGGGACACCGATCATCCCTT	0.532000													35	35					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89660999	89660999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89660999C>T	ENST00000355754.6	-	3	441	c.344G>A	c.(343-345)gGc>gAc	p.G115D		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	115						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		ATCGCCCAGGCCCTCGGTGTC	0.512000													32	81					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451240	55451240	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55451240G>A	ENST00000588756.1	-	6	1433	c.947C>T	c.(946-948)cCg>cTg	p.P316L	NLRP7_ENST00000328092.5_Missense_Mutation_p.P316L|NLRP7_ENST00000340844.2_Missense_Mutation_p.P316L|NLRP7_ENST00000448121.2_Missense_Mutation_p.P316L|NLRP7_ENST00000590030.1_Missense_Mutation_p.P316L|NLRP7_ENST00000592784.1_Missense_Mutation_p.P316L|NLRP7_ENST00000446217.1_Missense_Mutation_p.P344L			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	316	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TACGTAGATCGGCTGCTGCGC	0.607000													19	37					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2321209	2321209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2321209C>T	ENST00000381458.5	+	13	2127	c.2064C>T	c.(2062-2064)tcC>tcT	p.S688S		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	688					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	CCATGTTGTCCATCGATGTAG	0.587000													24	75					0	0	1	0	0
SMAD9	4093	broad.mit.edu	37	13	37453613	37453613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:37453613G>A	ENST00000379826.4	-	2	556	c.214C>T	c.(214-216)Ccc>Tcc	p.P72S	SMAD9_ENST00000399275.2_Missense_Mutation_p.P72S|SMAD9_ENST00000350148.5_Missense_Mutation_p.P72S|SMAD9_ENST00000483941.1_5'UTR	NM_001127217.2	NP_001120689.1	O15198	SMAD9_HUMAN	SMAD family member 9	72	MH1.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)	18		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		AGGGAGCGGGGAATCGTGACG	0.627000													14	64					0	0	1	0	0
LINC00303	284573	broad.mit.edu	37	1	204006215	204006215	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204006215G>A	ENST00000367207.3	-	0	805																											agtgtttgctgaatagaGAGG	0.557000													12	27					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39792036	39792036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39792036C>T	ENST00000373272.2	+	9	1213	c.808C>T	c.(808-810)Cgc>Tgc	p.R270C	PLCG1_ENST00000373271.1_Missense_Mutation_p.R270C|PLCG1_ENST00000244007.3_Missense_Mutation_p.R270C	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	270					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				GGCTGTTGATCGCCTCCAGGT	0.602000													22	56					0	0	1	0	0
FAM110C	642273	broad.mit.edu	37	2	45964	45964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:45964C>T	ENST00000327669.4	-	1	421	c.422G>A	c.(421-423)gGa>gAa	p.G141E		NM_001077710.2	NP_001071178.2	Q1W6H9	F110C_HUMAN	family with sequence similarity 110, member C	141						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		GCCCTCGTCTCCCGTCCGGGG	0.736000													4	17					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45009750	45009750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:45009750G>A	ENST00000258787.7	-	10	1357	c.1221C>T	c.(1219-1221)ttC>ttT	p.F407F		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	407	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						AGAACTGCTCGAAACTGGGGG	0.547000													8	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9086464	9086464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9086464G>A	ENST00000397910.4	-	1	5554	c.5351C>T	c.(5350-5352)tCt>tTt	p.S1784F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1784	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTTGCTGAAGACTTGGAGAT	0.468000													25	47					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215910690	215910690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215910690C>T	ENST00000272895.7	-	7	962	c.743G>A	c.(742-744)aGa>aAa	p.R248K		NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	248					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGACAGCATTCTGACTATTTC	0.373000													22	64					0	0	1	0	0
XCL2	6846	broad.mit.edu	37	1	168511246	168511246	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168511246G>A	ENST00000367819.2	-	2	193	c.161C>T	c.(160-162)tCc>tTc	p.S54F		NM_003175.3	NP_003166.1	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2	54					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			large_intestine(1)|lung(6)|ovary(1)	8	all_hematologic(923;0.215)					TGCTCTCAAGGAGCCTTCCGT	0.512000													25	49					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50776819	50776819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50776819G>A	ENST00000216923.4	-	5	955	c.606C>T	c.(604-606)ccC>ccT	p.P202P	ZFP64_ENST00000361387.2_Silent_p.P202P|ZFP64_ENST00000346617.4_Silent_p.P148P|ZFP64_ENST00000371518.2_Silent_p.P202P|ZFP64_ENST00000371515.4_Silent_p.P200P|ZFP64_ENST00000477786.1_5'UTR	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TACACTTGTAGGGCTTCACGC	0.547000													51	104					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921784	78921784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78921784G>A	ENST00000261751.3	-	5	974	c.863C>T	c.(862-864)aCc>aTc	p.T288I	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	288					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						ATCGAGGGAGGTGGGTGGCAC	0.562000													22	71					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176524640	176524640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176524640C>T	ENST00000292408.4	+	18	2617	c.2372C>T	c.(2371-2373)tCc>tTc	p.S791F	FGFR4_ENST00000502906.1_Missense_Mutation_p.S791F|FGFR4_ENST00000393648.2_Missense_Mutation_p.S723F|FGFR4_ENST00000393637.1_Missense_Mutation_p.S751F|FGFR4_ENST00000292410.3_Missense_Mutation_p.S751F	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	791					insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CCATTGGGATCCAGCTCCTTC	0.642000										TSP Lung(9;0.080)			29	62					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422810	26422810	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26422810G>A	ENST00000335473.7	+	43	7120	c.6870G>A	c.(6868-6870)agG>agA	p.R2290R	MYO18B_ENST00000536101.1_Silent_p.R2290R|MYO18B_ENST00000407587.2_Silent_p.R2291R	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2290						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCACACTAAGGAGGGGCAGGG	0.637000													4	20					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102220766	102220766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102220766C>T	ENST00000227758.2	+	2	1580	c.181C>T	c.(181-183)Cct>Tct	p.P61S	BIRC2_ENST00000527910.1_3'UTR|BIRC2_ENST00000530675.1_Missense_Mutation_p.P12S|BIRC2_ENST00000532672.1_Missense_Mutation_p.P40S	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	61					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		CGCCGGGGTGCCTGTCTCAGA	0.428000													26	124					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52926959	52926959	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52926959G>A	ENST00000295213.4	+	3	579	c.205G>A	c.(205-207)Gat>Aat	p.D69N	SPATA18_ENST00000506829.1_Intron|SPATA18_ENST00000419395.2_Missense_Mutation_p.D69N	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	69					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AGGACGTAATGATGGTGTGGA	0.458000													9	74					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222294837	222294837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:222294837G>A	ENST00000281821.2	-	15	2572	c.2531C>T	c.(2530-2532)cCc>cTc	p.P844L	EPHA4_ENST00000409938.1_Missense_Mutation_p.P844L|EPHA4_ENST00000409854.1_Missense_Mutation_p.P844L|EPHA4_ENST00000392071.4_Missense_Mutation_p.P793L	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	844	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CATTGGAGGGGGTAACCGATA	0.522000													28	81					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716551	13716551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13716551C>T	ENST00000279593.3	-	13	3830	c.3621G>A	c.(3619-3621)gaG>gaA	p.E1207E		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1207					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGGACCGGTCCTCCCACTCCA	0.637000													30	75					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476430	57476430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57476430G>A	ENST00000371236.2	-	14	1869	c.1606C>T	c.(1606-1608)Cca>Tca	p.P536S	DAB1_ENST00000420954.2_Missense_Mutation_p.P534S|DAB1_ENST00000439789.2_Missense_Mutation_p.P450S|DAB1_ENST00000371234.4_Missense_Mutation_p.P536S|DAB1_ENST00000371231.1_Missense_Mutation_p.P569S|DAB1_ENST00000414851.2_Missense_Mutation_p.P518S|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	569					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TCACCAAATGGATCACTGTTG	0.438000													31	84					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35406890	35406890	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:35406890G>A	ENST00000287272.2	+	2	204	c.184G>A	c.(184-186)Gat>Aat	p.D62N	UNC5D_ENST00000416672.1_Missense_Mutation_p.D62N|UNC5D_ENST00000420357.1_Missense_Mutation_p.D62N|UNC5D_ENST00000404895.2_Missense_Mutation_p.D62N|UNC5D_ENST00000453357.2_Missense_Mutation_p.D57N			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	62	Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GGAGCCAGATGATGCTTATAT	0.483000													13	45					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75042611	75042611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75042611G>A	ENST00000326665.5	-	13	2404	c.2186C>T	c.(2185-2187)tCa>tTa	p.S729L	C1orf173_ENST00000433746.2_Intron	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	729	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TAATGGCAATGAATCCTTTCC	0.388000													13	36					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60069930	60069930	+	Splice_Site	SNP	C	C	T	rs11559108		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:60069930C>T	ENST00000267484.5	-	7	2564	c.2229_splice	c.e7+1	p.Q743_splice	RTN1_ENST00000342503.4_Splice_Site_p.Q175_splice|RTN1_ENST00000395090.1_Splice_Site_p.Q160_splice|RTN1_ENST00000557422.1_5'UTR	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	743	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity	p.Q743H(1)		central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TAGAACTTACCTGGTGCTTAA	0.318000													20	42					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152737851	152737851	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152737851C>T	ENST00000367255.5	-	41	6322	c.5721G>A	c.(5719-5721)aaG>aaA	p.K1907K	SYNE1_ENST00000448038.1_Silent_p.K1914K|SYNE1_ENST00000423061.1_Silent_p.K1914K|SYNE1_ENST00000265368.4_Silent_p.K1907K|SYNE1_ENST00000341594.5_Silent_p.K1944K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1907					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CATTGAGGTCCTTTTCTATCA	0.463000										HNSCC(10;0.0054)			25	30					0	0	1	0	0
LSS	4047	broad.mit.edu	37	21	47636337	47636337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47636337G>A	ENST00000397728.3	-	7	827	c.749C>T	c.(748-750)gCc>gTc	p.A250V	LSS_ENST00000464357.1_5'UTR|LSS_ENST00000457828.2_Missense_Mutation_p.A170V|LSS_ENST00000522411.1_Missense_Mutation_p.A239V|LSS_ENST00000356396.4_Missense_Mutation_p.A250V	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	250					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					GTCTTCCGCGGCACTCAGCCG	0.652000													14	57					0	0	1	0	0
SHQ1	55164	broad.mit.edu	37	3	72842128	72842128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:72842128G>A	ENST00000325599.8	-	10	1259	c.1120C>T	c.(1120-1122)Cca>Tca	p.P374S	SHQ1_ENST00000468371.1_5'UTR|SHQ1_ENST00000463369.1_Missense_Mutation_p.P346S	NM_018130.2	NP_060600.2	Q6PI26	SHQ1_HUMAN	SHQ1, H/ACA ribonucleoprotein assembly factor	374					ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		ATGTACGCTGGGTCATTTTCC	0.308000													9	89					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247597450	247597450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247597450C>T	ENST00000366497.2	+	6	3153	c.2373C>T	c.(2371-2373)tcC>tcT	p.S791S	NLRP3_ENST00000391828.3_Silent_p.S791S|NLRP3_ENST00000336119.3_Silent_p.S791S|NLRP3_ENST00000391827.2_Silent_p.S734S|NLRP3_ENST00000348069.2_Silent_p.S734S|NLRP3_ENST00000366496.2_Silent_p.S791S	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	848					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCGACATCTCCTTGGTCCTCA	0.567000													40	100					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125367398	125367398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125367398G>A	ENST00000431078.1	+	12	2138	c.1774G>A	c.(1774-1776)Gag>Aag	p.E592K		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	592	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCAATCCTGCGAGGTGTACAG	0.517000													16	77					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77748454	77748454	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:77748454G>A	ENST00000407578.2	-	37	5909	c.5643C>T	c.(5641-5643)ctC>ctT	p.L1881L	MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Silent_p.L1843L|MYCBP2_ENST00000544440.2_Silent_p.L1843L	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1843			A -> S (in dbSNP:rs35887505).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACCTATAGTAGAGTATCTGTG	0.433000													20	83					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23906980	23906980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:23906980G>A	ENST00000382298.3	-	10	11623	c.11035C>T	c.(11035-11037)Ctt>Ttt	p.L3679F	SACS_ENST00000402364.1_Missense_Mutation_p.L2929F|SACS_ENST00000382292.3_Missense_Mutation_p.L3679F	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3679					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AACTTTATAAGAGGAAGTGTT	0.408000													28	77					0	0	1	0	0
CERS6	253782	broad.mit.edu	37	2	169417815	169417815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169417815G>A	ENST00000305747.6	+	3	977	c.390G>A	c.(388-390)acG>acA	p.T130T	CERS6_ENST00000392687.4_Silent_p.T130T	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	130	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GCACGCTGACGAGGTTCTGTG	0.463000													39	112					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36260883	36260883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36260883C>T	ENST00000394571.2	+	3	484	c.484C>T	c.(484-486)Ccc>Tcc	p.P162S	PNPLA1_ENST00000388715.3_Missense_Mutation_p.P67S|PNPLA1_ENST00000312917.5_Missense_Mutation_p.P67S	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	162	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						TGGCCTCATCCCCCCGACTTA	0.652000													29	71					0	0	1	0	0
FAM50B	26240	broad.mit.edu	37	6	3850651	3850651	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:3850651G>A	ENST00000380274.1	+	1	1032	c.606G>A	c.(604-606)cgG>cgA	p.R202R	FAM50B_ENST00000380272.3_Silent_p.R202R			Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	202						nucleus				cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(3)|urinary_tract(3)	17	Ovarian(93;0.0925)	all_hematologic(90;0.108)				GCACGGTGCGGGTGCGCAAGG	0.672000													36	54					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29398864	29398864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:29398864G>A	ENST00000558402.1	+	13	2358	c.1759G>A	c.(1759-1761)Ggc>Agc	p.G587S	APBA2_ENST00000411764.1_Missense_Mutation_p.G575S|APBA2_ENST00000558330.1_Missense_Mutation_p.G575S|APBA2_ENST00000558259.1_Missense_Mutation_p.G587S|APBA2_ENST00000561069.1_Missense_Mutation_p.G587S			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	587	PDZ 1.				nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGTGGAGTCGGGCTGGGGCTC	0.652000													6	75					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7701593	7701593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7701593C>T	ENST00000572933.1	+	54	9809	c.8349C>T	c.(8347-8349)acC>acT	p.T2783T	DNAH2_ENST00000389173.2_Silent_p.T2783T			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2783	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACTACACCACCTTCCAGATCG	0.542000													30	33					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42821107	42821107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42821107G>A	ENST00000598766.1	+	11	964	c.964G>A	c.(964-966)Gag>Aag	p.E322K	TMEM145_ENST00000301204.3_Missense_Mutation_p.E298K			Q8NBT3	TM145_HUMAN	transmembrane protein 145	298						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				GCTCATCTACGAGGCGGAAGT	0.657000													11	29					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847485	123847485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123847485C>T	ENST00000531945.1	-	1	1003	c.914G>A	c.(913-915)cGg>cAg	p.R305Q		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTCCTTGTTCCGCAAAGTGTA	0.532000													54	89					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218683158	218683158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:218683158G>A	ENST00000171887.4	-	24	4037	c.3585C>T	c.(3583-3585)ttC>ttT	p.F1195F	TNS1_ENST00000430930.1_Silent_p.F1174F|TNS1_ENST00000419504.1_Silent_p.F1182F	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1195						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CCCGCCAGCCGAAGCCAGGAC	0.637000													37	66					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655306	46655306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46655306C>T	ENST00000253255.5	-	1	3913	c.3914G>A	c.(3913-3915)cGa>cAa	p.R1305Q		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1305	PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GCTAGGCGATCGACCCTCGTT	0.453000													16	105					0	0	1	0	0
HDGFL1	154150	broad.mit.edu	37	6	22570398	22570398	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:22570398C>T	ENST00000510882.2	+	1	604	c.594C>T	c.(592-594)ctC>ctT	p.L198L	HDGFL1_ENST00000230012.3_Silent_p.L198L			Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	198	Glu-rich.			L -> P (in Ref. 1; BAB71292).						kidney(1)|large_intestine(3)|lung(7)	11	Ovarian(93;0.163)					GTCCGTTCCTCGTGGCGGTGG	0.746000													3	6					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157244	22157244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22157244C>T	ENST00000397126.4	-	4	740	c.592G>A	c.(592-594)Gag>Aag	p.E198K	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAGGAATTCTCTCTAGTATAA	0.363000													28	58					0	0	1	0	0
DYDC2	84332	broad.mit.edu	37	10	82126582	82126582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:82126582C>T	ENST00000372199.1	+	6	1007	c.409C>T	c.(409-411)Cct>Tct	p.P137S	DYDC2_ENST00000256039.2_Missense_Mutation_p.P137S|DYDC2_ENST00000372198.1_Missense_Mutation_p.P151S|DYDC2_ENST00000444807.2_Missense_Mutation_p.P137S|DYDC2_ENST00000372197.1_Missense_Mutation_p.P137S			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	137							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			TCAACAGGTTCCTCCTTCAGA	0.473000													52	126					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108869898	108869898	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108869898G>A	ENST00000329106.2	+	3	399	c.399_splice	c.e3+1	p.K133_splice	SULT1C3_ENST00000376700.1_Splice_Site_p.K133_splice	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	133						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						AAAACTGCAAGGTATAAAGAG	0.338000													24	54					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7679435	7679435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7679435C>T	ENST00000256861.6	-	5	486	c.408G>A	c.(406-408)aaG>aaA	p.K136K	ITIH5_ENST00000446830.2_5'UTR|ITIH5_ENST00000397146.2_Silent_p.K136K|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Silent_p.K136K	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	136	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TTTCAGTCCCCTTCTCTCTGT	0.542000													7	78					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57088523	57088523	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57088523C>T	ENST00000330619.8	+	6	1412	c.726C>T	c.(724-726)acC>acT	p.T242T	ZNF470_ENST00000391709.3_Silent_p.T242T|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AAATCTCAACCCTTACTCTTC	0.373000													21	67					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54159206	54159206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:54159206G>A	ENST00000404125.1	-	10	1137	c.1082C>T	c.(1081-1083)cCa>cTa	p.P361L	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	361					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AACACTGTTTGGCAACCGCTG	0.423000													16	173					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218683210	218683210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:218683210G>A	ENST00000171887.4	-	24	3985	c.3533C>T	c.(3532-3534)cCt>cTt	p.P1178L	TNS1_ENST00000430930.1_Missense_Mutation_p.P1157L|TNS1_ENST00000419504.1_Missense_Mutation_p.P1165L	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1178						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GCGCGCCTGAGGGCTCCCAGG	0.642000													31	53					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388705	48388705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48388705C>T	ENST00000224600.4	-	1	2286	c.2173G>A	c.(2173-2175)Gag>Aag	p.E725K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	725	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	TAGGTGAGCTCCTCTGGAGAG	0.617000													23	34					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7698957	7698957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:7698957G>A	ENST00000507866.2	+	12	1733	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K	SORCS2_ENST00000329016.9_Missense_Mutation_p.E370K	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	542						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						GGAATATAAAGAAGAAATGTA	0.547000													3	11					0	0	1	0	0
INTS4P2	644619	broad.mit.edu	37	7	65160009	65160009	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:65160009C>T	ENST00000430126.2	+	0	1179																											GTGTCATCAGCTGTTTCTCCC	0.463000													23	39					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49663596	49663596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49663596C>T	ENST00000339139.4	-	9	793	c.557G>A	c.(556-558)gGa>gAa	p.G186E		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	186						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			ACAAGGTGTTCCTTGTTGGTA	0.338000													22	61					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871842	51871842	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51871842G>A	ENST00000371497.5	+	2	2732	c.1845G>A	c.(1843-1845)ggG>ggA	p.G615G	TSHZ2_ENST00000603338.2_Silent_p.G612G|TSHZ2_ENST00000329613.6_Silent_p.G612G	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	615					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AGGAGTGTGGGAAAGAAAGTC	0.507000													9	114					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110535021	110535021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110535021G>A	ENST00000378402.5	+	75	12336	c.12232G>A	c.(12232-12234)Gcc>Acc	p.A4078T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	4078					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCATCACGTGGCCTTCGTGTC	0.512000										HNSCC(38;0.096)			11	29					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900372	151900372	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151900372G>A	ENST00000393900.3	-	3	782	c.429C>T	c.(427-429)ttC>ttT	p.F143F	MAGEA12_ENST00000357916.4_Silent_p.F143F|MAGEA12_ENST00000393869.3_Silent_p.F143F|CSAG4_ENST00000361201.4_RNA	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	143	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					AGAAGTCCTGGAAATTTCTGA	0.507000													100	66					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204587210	204587210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204587210G>A	ENST00000367175.1	-	1	4123	c.1911C>T	c.(1909-1911)ctC>ctT	p.L637L	LRRN2_ENST00000367176.3_Silent_p.L637L|LRRN2_ENST00000367177.3_Silent_p.L637L			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	637					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GAAGGACAGCGAGAGCCAGGA	0.647000													12	23					0	0	1	0	0
TBC1D25	4943	broad.mit.edu	37	X	48419014	48419014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48419014C>T	ENST00000376771.4	+	6	2059	c.1718C>T	c.(1717-1719)cCc>cTc	p.P573L	TBC1D25_ENST00000537536.1_Missense_Mutation_p.P319L|TBC1D25_ENST00000427713.1_3'UTR	NM_002536.2	NP_002527.1	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	573						intracellular	Rab GTPase activator activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GAGGCCTCTCCCACTGGTGAT	0.577000													41	53					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216595578	216595578	+	Missense_Mutation	SNP	C	C	T	rs141672841	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216595578C>T	ENST00000366943.2	-	2	487	c.101G>A	c.(100-102)cGa>cAa	p.R34Q	USH2A_ENST00000366942.3_Missense_Mutation_p.R34Q|USH2A_ENST00000307340.3_Missense_Mutation_p.R34Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	34					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAAAAGACCTCGTGACTCAGT	0.453000										HNSCC(13;0.011)			30	73					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113421178	113421178	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113421178G>A	ENST00000297405.5	-	33	5723	c.5479C>T	c.(5479-5481)Ctg>Ttg	p.L1827L	CSMD3_ENST00000455883.2_Silent_p.L1723L|CSMD3_ENST00000343508.3_Silent_p.L1787L|CSMD3_ENST00000352409.3_Intron	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1827	CUB 10.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GAAGATAACAGAGAAGATTGC	0.418000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			37	130					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50610836	50610836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:50610836G>A	ENST00000371824.1	+	2	474	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	ELAVL4_ENST00000357083.4_Missense_Mutation_p.E90K|ELAVL4_ENST00000492299.1_3'UTR|ELAVL4_ENST00000371823.4_Missense_Mutation_p.E73K|ELAVL4_ENST00000371821.1_Missense_Mutation_p.E78K|ELAVL4_ENST00000448907.2_Missense_Mutation_p.E76K|ELAVL4_ENST00000371819.1_Missense_Mutation_p.E78K|ELAVL4_ENST00000371827.1_Missense_Mutation_p.E73K			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	73	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						TGGTGAAATAGAATCCTGCAA	0.413000													23	96					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54735313	54735313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54735313G>A	ENST00000306858.7	+	2	385	c.269G>A	c.(268-270)gGg>gAg	p.G90E		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	90										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTATCTTCAGGGACCTACTGG	0.443000													30	147					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4673781	4673781	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4673781G>A	ENST00000396952.5	+	2	675	c.25G>A	c.(25-27)Gaa>Aaa	p.E9K	OR51E1_ENST00000530215.1_Missense_Mutation_p.E9K	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	8			S -> N (in dbSNP:rs17224476).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAATGGCAATGAATCCAGTGC	0.488000													44	116					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95142932	95142932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95142932G>A	ENST00000027335.3	-	17	2444	c.2320C>T	c.(2320-2322)Cgg>Tgg	p.R774W	CDH17_ENST00000441892.2_Intron|CDH17_ENST00000450165.2_Missense_Mutation_p.R774W	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	774	Cadherin 7.					integral to membrane	calcium ion binding	p.R774W(1)		NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CCTGCTGGCCGGAAACAACTT	0.448000													15	34					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45279062	45279062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45279062C>T	ENST00000313237.5	-	13	1650	c.1500G>A	c.(1498-1500)acG>acA	p.T500T	PHF21B_ENST00000403565.1_Silent_p.T296T|PHF21B_ENST00000404079.2_Silent_p.T446T|PHF21B_ENST00000396103.3_Silent_p.T458T	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	500							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GGCTAGTGGTCGTCATGGTGA	0.701000													27	94					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147113688	147113688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:147113688C>T	ENST00000383075.3	-	3	1151	c.639G>A	c.(637-639)aaG>aaA	p.K213K	ZIC4_ENST00000525172.2_Silent_p.K263K|ZIC4_ENST00000425731.3_Silent_p.K251K|ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000473123.1_Silent_p.K213K|ZIC4_ENST00000484399.1_Silent_p.K213K	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	213						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TAGCAAAGACCTTCCCACACC	0.537000													41	100					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101777979	101777979	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101777979C>T	ENST00000334289.3	-	3	692		c.e3-1			NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5						signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		CTGAAGAGTCCTTTATATTAA	0.269000													6	10					0	0	1	0	0
HNF1A	6927	broad.mit.edu	37	12	121434128	121434128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121434128C>T	ENST00000257555.6	+	5	1245	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	HNF1A_ENST00000538626.1_Intron|HNF1A_ENST00000543427.1_Missense_Mutation_p.P223L|HNF1A_ENST00000402929.1_Missense_Mutation_p.P340L|HNF1A_ENST00000400024.2_Missense_Mutation_p.P340L|HNF1A_ENST00000541395.1_Missense_Mutation_p.P340L|HNF1A_ENST00000544413.1_Missense_Mutation_p.P340L			P20823	HNF1A_HUMAN	HNF1 homeobox A	340					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGCGGCGGTCCCTTAGTGACA	0.617000									Hepatic Adenoma, Familial Clustering of				43	114					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628478	173628478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173628478G>A	ENST00000333279.2	-	2	140	c.80C>T	c.(79-81)gCc>gTc	p.A27V		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	43										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						tggttcttgggcttcttcttc	0.438000													9	22					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020050	56020050	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56020050C>T	ENST00000303059.3	+	1	375	c.375C>T	c.(373-375)atC>atT	p.I125I		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TTTCATTTATCGGATGTGCAA	0.358000													60	167					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104042572	104042572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104042572G>A	ENST00000388887.2	+	10	1349	c.1145G>A	c.(1144-1146)gGa>gAa	p.G382E		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	382	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AAATGGCAAGGAAGGCTGACC	0.443000													38	83					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874348	36874348	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36874348G>A	ENST00000301807.6	-	21	6841	c.4944C>T	c.(4942-4944)ttC>ttT	p.F1648F	TRANK1_ENST00000429976.2_Silent_p.F2198F|TRANK1_ENST00000428977.2_Silent_p.F1648F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2198					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGATTTTAGGGAATACTTTTT	0.403000													18	42					0	0	1	0	0
CKAP4	10970	broad.mit.edu	37	12	106633295	106633295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:106633295G>A	ENST00000378026.4	-	2	1452	c.1316C>T	c.(1315-1317)tCc>tTc	p.S439F		NM_006825.3	NP_006816.2	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	439						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction				NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|pancreas(1)|urinary_tract(1)	20						CTGGCTCTTGGACAGGAGGGA	0.687000													9	79					0	0	1	0	0
KDM5D	8284	broad.mit.edu	37	Y	21903332	21903332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:21903332G>A	ENST00000541639.1	-	5	681	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C	KDM5D_ENST00000382806.2_Intron|KDM5D_ENST00000317961.4_Missense_Mutation_p.R132C	NM_001146705.1	NP_001140177.1	Q9BY66	KDM5D_HUMAN	lysine (K)-specific demethylase 5D	132	ARID.				chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(1)|large_intestine(9)|lung(6)|skin(1)	17					Vitamin C(DB00126)	GCCCACCGACGATCCTTGCAG	0.478000													10	16					0	0	1	0	0
TPSG1	25823	broad.mit.edu	37	16	1272059	1272059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1272059C>T	ENST00000234798.4	-	6	699	c.695G>A	c.(694-696)gGt>gAt	p.G232D		NM_012467.3	NP_036599.3	Q9NRR2	TRYG1_HUMAN	tryptase gamma 1	232	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			liver(1)|lung(2)|skin(1)	4		Hepatocellular(780;0.00369)				CACCCAGGCACCGTTCACCTG	0.667000													17	41					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8180457	8180457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8180457G>A	ENST00000600128.1	-	30	4194	c.3780C>T	c.(3778-3780)tcC>tcT	p.S1260S	FBN3_ENST00000601739.1_Silent_p.S1260S|FBN3_ENST00000270509.2_Silent_p.S1260S			Q75N90	FBN3_HUMAN	fibrillin 3	1260	EGF-like 18; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GGCAGACAAAGGAACCCTTCG	0.612000													12	43					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48239742	48239742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48239742G>A	ENST00000263277.3	+	5	1283	c.1032G>A	c.(1030-1032)ctG>ctA	p.L344L	EHD2_ENST00000538399.1_Silent_p.L208L|EHD2_ENST00000540884.1_3'UTR	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	344					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		AGATTCAGCTGGAACATCACA	0.527000													36	53					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11400787	11400787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:11400787G>A	ENST00000259089.4	+	2	646	c.54G>A	c.(52-54)aaG>aaA	p.K18K	BLK_ENST00000529894.1_Intron	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	18					intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TCAAAGAGAAGGACAAGGGCC	0.607000													18	59					0	0	1	0	0
SLC47A1	55244	broad.mit.edu	37	17	19480832	19480832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:19480832G>A	ENST00000270570.4	+	17	1765	c.1679G>A	c.(1678-1680)gGg>gAg	p.G560E	SLC47A1_ENST00000436810.2_3'UTR|RP11-1113L8.1_ENST00000574267.1_RNA|SLC47A1_ENST00000571335.1_Missense_Mutation_p.G306E|SLC47A1_ENST00000575023.1_Missense_Mutation_p.G258E|SLC47A1_ENST00000457293.1_Intron|SLC47A1_ENST00000395585.1_Intron	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	560						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TTGCTGGTGGGGATTTTAGTG	0.502000													41	76					0	0	1	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130674663	130674663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130674663G>A	ENST00000335791.5	-	4	770	c.495C>T	c.(493-495)acC>acT	p.T165T	ST6GALNAC4_ENST00000343609.2_Silent_p.T81T|ST6GALNAC4_ENST00000495983.1_5'UTR	NM_175039.3	NP_778204.1	Q9H4F1	SIA7D_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	165					glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7						GCGTGCGGTAGGTGCGGCCGC	0.632000													22	62					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239010604	239010604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239010604C>T	ENST00000343063.3	+	2	580	c.317C>T	c.(316-318)tCc>tTc	p.S106F	ESPNL_ENST00000409169.1_Missense_Mutation_p.S106F	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	106										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		TCGGGCGTCTCCCCGCTGCAC	0.706000													7	13					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60183867	60183867	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60183867G>A	ENST00000300187.6	+	5	1703	c.1426G>A	c.(1426-1428)Gaa>Aaa	p.E476K	MS4A14_ENST00000395005.2_Missense_Mutation_p.E459K|MS4A14_ENST00000531783.1_Missense_Mutation_p.E509K|MS4A14_ENST00000531787.1_Missense_Mutation_p.E364K	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	476	Gln-rich.					integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						ATCTGAGGAGGAACTCCATAG	0.383000													12	98					0	0	1	0	0
NAA35	60560	broad.mit.edu	37	9	88611379	88611379	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:88611379C>T	ENST00000361671.5	+	12	1076	c.943C>T	c.(943-945)Cga>Tga	p.R315*		NM_024635.3	NP_078911.3	Q5VZE5	NAA35_HUMAN	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	315					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	25						TACCTTCCCTCGATATGCAAA	0.313000													9	67					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98355350	98355350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98355350G>A	ENST00000339364.5	-	17	2521	c.2402C>T	c.(2401-2403)cCa>cTa	p.P801L	PIK3AP1_ENST00000371109.3_Missense_Mutation_p.P400L|PIK3AP1_ENST00000371110.2_Missense_Mutation_p.P623L	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	801	Pro-rich.					cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		TCCTCTGGGTGGAACAGGTGG	0.428000													18	42					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9036102	9036102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9036102G>A	ENST00000383836.3	-	19	2760	c.2333C>T	c.(2332-2334)tCg>tTg	p.S778L	SRGAP3_ENST00000360413.3_Missense_Mutation_p.S754L	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	778	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCAGTCCTCCGAGGCGCGGTG	0.587000			T	RAF1	pilocytic astrocytoma								29	80					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49776046	49776046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:49776046C>T	ENST00000492622.2	+	24	3403	c.3098C>T	c.(3097-3099)cCc>cTc	p.P1033L	FNDC3A_ENST00000541916.1_Missense_Mutation_p.P1033L|FNDC3A_ENST00000398316.3_Missense_Mutation_p.P977L	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1033	Fibronectin type-III 8.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		GGGGAAGGTCCCCTCTCCCAA	0.353000													27	83					0	0	1	0	0
NAT16	375607	broad.mit.edu	37	7	100817986	100817986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100817986C>T	ENST00000300303.2	-	2	341	c.103G>A	c.(103-105)Gag>Aag	p.E35K	NAT16_ENST00000455377.1_Missense_Mutation_p.E35K|NAT16_ENST00000443096.1_Missense_Mutation_p.E35K	NM_198571.2	NP_940973.2	Q8N8M0	CG052_HUMAN	N-acetyltransferase 16 (GCN5-related, putative)	35							N-acetyltransferase activity	p.E35K(1)									GCCTCCACCTCCTGTGGCCGG	0.637000													32	90					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19195292	19195292	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19195292G>A	ENST00000562034.1	+	3	4389	c.591G>A	c.(589-591)gaG>gaA	p.E197E	SYT17_ENST00000568115.1_Silent_p.E197E|SYT17_ENST00000562711.2_Silent_p.E254E|SYT17_ENST00000355377.2_Silent_p.E258E			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	258	C2 1.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						TGTTTGAGGAGCGCTACACCT	0.572000													19	137					0	0	1	0	0
RSAD2	91543	broad.mit.edu	37	2	7018127	7018127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:7018127C>T	ENST00000382040.3	+	1	332	c.196C>T	c.(196-198)Cct>Tct	p.P66S		NM_080657.4	NP_542388.2	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing 2	66					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)	20	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		GGAAGAGGACCCTCCTCTGCC	0.552000													23	57					0	0	1	0	0
TAF8	129685	broad.mit.edu	37	6	42034064	42034064	+	Silent	SNP	C	C	T	rs80150955	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42034064C>T	ENST00000372977.3	+	6	522	c.504C>T	c.(502-504)ccC>ccT	p.P168P	TAF8_ENST00000465926.1_Silent_p.P105P|TAF8_ENST00000456846.2_Silent_p.P168P|TAF8_ENST00000494547.1_Silent_p.P168P|TAF8_ENST00000372982.4_Silent_p.P168P	NM_138572.2	NP_612639.2	Q7Z7C8	TAF8_HUMAN	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa	168					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			ACCGTGAGCCCGTGTCAGACT	0.577000													15	32					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95680230	95680230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95680230C>T	ENST00000433389.2	+	10	1175	c.985C>T	c.(985-987)Cgc>Tgc	p.R329C	ESRP1_ENST00000358397.5_Missense_Mutation_p.R329C|ESRP1_ENST00000454170.2_Missense_Mutation_p.R329C|ESRP1_ENST00000423620.2_Missense_Mutation_p.R329C	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	329	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						AGTCATTGTCCGCATGCGGGG	0.483000													14	49					0	0	1	0	0
RNFT2	84900	broad.mit.edu	37	12	117271695	117271695	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117271695C>T	ENST00000257575.4	+	8	1214	c.981C>T	c.(979-981)tcC>tcT	p.S327S	RNFT2_ENST00000319176.7_Intron|RNFT2_ENST00000407967.3_Silent_p.S327S|RNFT2_ENST00000392549.2_Silent_p.S327S			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	327						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		ACGACTCCTCCAACAGCTACT	0.582000													8	24					0	0	1	0	0
SAMD12	401474	broad.mit.edu	37	8	119391794	119391794	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:119391794G>A	ENST00000314727.4	-	4	604	c.468C>T	c.(466-468)acC>acT	p.T156T	AC023590.1_ENST00000430457.1_Intron|SAMD12_ENST00000527515.1_Intron|SAMD12_ENST00000409003.4_Intron	NM_207506.2	NP_997389.2	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12	156										endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)	9	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			GAAGCAATAGGGTACCTTGTG	0.473000													17	62					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27744833	27744833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27744833G>A	ENST00000430629.2	-	4	571	c.356C>T	c.(355-357)cCt>cTt	p.P119L	WASF2_ENST00000536657.1_Missense_Mutation_p.P119L	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	119					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TTCTAAGACAGGCACTGGGAG	0.458000													33	91					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57060874	57060874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57060874C>T	ENST00000436936.1	+	6	2244	c.2019C>T	c.(2017-2019)ccC>ccT	p.P673P	NLRC5_ENST00000308149.7_Silent_p.P673P|NLRC5_ENST00000262510.6_Silent_p.P673P|NLRC5_ENST00000539144.1_Silent_p.P673P			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	673					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				ATGGCTGTCCCCTGGAGCCCC	0.597000													24	47					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47405691	47405691	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47405691G>A	ENST00000295454.3	+	7	1090	c.798G>A	c.(796-798)tgG>tgA	p.W266*	GABRB1_ENST00000538619.1_Nonsense_Mutation_p.W196*	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	266					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TGTCTTTTTGGATCAACTATG	0.383000													12	72					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625476	140625476	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140625476G>A	ENST00000231173.3	+	1	330	c.330G>A	c.(328-330)ctG>ctA	p.L110L		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		110	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGTGTTACTGAAAAAACCTT	0.438000													46	116					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833963	61833963	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61833963C>T	ENST00000280772.1	-	37	6867	c.6676G>A	c.(6676-6678)Gaa>Aaa	p.E2226K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2226					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TCATCTTCTTCACTACTGGCT	0.408000													31	136					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42237142	42237142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42237142C>T	ENST00000541110.1	-	5	755	c.187G>A	c.(187-189)Gat>Aat	p.D63N	TRERF1_ENST00000340840.2_Missense_Mutation_p.D63N|TRERF1_ENST00000354325.2_Missense_Mutation_p.D63N|TRERF1_ENST00000372917.4_Missense_Mutation_p.D63N|TRERF1_ENST00000372922.4_Missense_Mutation_p.D63N			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	63					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCCAGACCATCCCGTGTATCT	0.587000													28	108					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150648860	150648860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150648860G>A	ENST00000392968.2	-	5	2453	c.1333C>T	c.(1333-1335)Cgc>Tgc	p.R445C	KCNH2_ENST00000430723.3_Missense_Mutation_p.R541C|KCNH2_ENST00000262186.5_Missense_Mutation_p.R541C|KCNH2_ENST00000330883.4_Missense_Mutation_p.R201C			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	541					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TCTGAGTAGCGATCCAGCTTC	0.642000													7	32					0	0	1	0	0
SUCLA2	8803	broad.mit.edu	37	13	48571090	48571090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:48571090G>A	ENST00000378654.3	-	2	215	c.159C>T	c.(157-159)ctC>ctT	p.L53L	SUCLA2_ENST00000544100.1_5'UTR|SUCLA2_ENST00000497202.1_5'UTR|SUCLA2_ENST00000534875.1_5'UTR|SUCLA2_ENST00000543413.1_5'UTR	NM_003850.2	NP_003841.1	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	53					succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(4)	15		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	CATGTAGTGAGAGATTCCTTT	0.403000													29	59					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5662644	5662644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5662644G>A	ENST00000425013.2	-	17	2672	c.2448C>T	c.(2446-2448)ttC>ttT	p.F816F	RNF216_ENST00000469375.1_5'UTR|RNF216_ENST00000389902.3_Silent_p.F873F	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	816	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		GGAAGTTGTTGAACACAGGCC	0.652000													33	119					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176008478	176008478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176008478G>A	ENST00000510636.1	+	17	2227	c.1953G>A	c.(1951-1953)gaG>gaA	p.E651E	CDHR2_ENST00000261944.5_Silent_p.E651E|CDHR2_ENST00000506348.1_Silent_p.E651E	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	651	Cadherin 6.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TGGACAGAGAGGCCATCGACC	0.622000													18	50					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17250265	17250265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:17250265G>A	ENST00000285681.2	+	24	3415	c.3046G>A	c.(3046-3048)Gat>Aat	p.D1016N	USP25_ENST00000400183.2_Missense_Mutation_p.D1054N|USP25_ENST00000351097.5_Missense_Mutation_p.D379N|USP25_ENST00000285679.6_Missense_Mutation_p.D984N			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	984					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AGCTGTAGAAGATATGAGAAA	0.363000													13	59					0	0	1	0	0
CD3D	915	broad.mit.edu	37	11	118211092	118211092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118211092C>T	ENST00000300692.4	-	2	408	c.272G>A	c.(271-273)cGa>cAa	p.R91Q	CD3D_ENST00000392884.2_Missense_Mutation_p.R91Q|CD3D_ENST00000529594.1_Intron	NM_000732.4	NP_000723.1	P04234	CD3D_HUMAN	CD3d molecule, delta (CD3-TCR complex)	91					positive thymic T cell selection|T cell costimulation|T cell receptor signaling pathway	cytoplasm|integral to membrane	protein heterodimerization activity			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	9	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		GCACGTACTTCGATAATGAAC	0.463000													14	55					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086302	100086302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100086302C>T	ENST00000423930.1	+	4	1117	c.958C>T	c.(958-960)Cct>Tct	p.P320S	NYAP1_ENST00000454988.1_Missense_Mutation_p.P263S|NYAP1_ENST00000300179.2_Missense_Mutation_p.P320S			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	320	Pro-rich.																CAAGACCACTCCTTGTGAAAT	0.687000													48	102					0	0	1	0	0
CYP4V2	285440	broad.mit.edu	37	4	187131739	187131739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187131739C>T	ENST00000378802.4	+	11	1826	c.1522C>T	c.(1522-1524)Cgt>Tgt	p.R508C	CYP4V2_ENST00000502665.1_3'UTR	NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	508			R -> H (in BCD).		response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		GTTGATTCTTCGTCCAAGTAA	0.403000													22	76					0	0	1	0	0
SF3A1	10291	broad.mit.edu	37	22	30742481	30742481	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30742481G>A	ENST00000439242.1	-	3	344	c.213C>T	c.(211-213)atC>atT	p.I71I	SF3A1_ENST00000215793.7_Silent_p.I71I	NM_001005409.1	NP_001005409.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	71					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						CGTTCTGTCGGATCCTAGCTT	0.483000													44	92					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10792813	10792813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10792813C>T	ENST00000449870.1	+	12	1642	c.1325C>T	c.(1324-1326)tCa>tTa	p.S442L	ILF3_ENST00000589998.1_Missense_Mutation_p.S442L|ILF3_ENST00000588657.1_Missense_Mutation_p.S442L|ILF3_ENST00000407004.3_Missense_Mutation_p.S442L|ILF3_ENST00000590261.1_Missense_Mutation_p.S442L|ILF3_ENST00000592763.1_Missense_Mutation_p.S442L|ILF3_ENST00000420083.1_Missense_Mutation_p.S442L|ILF3_ENST00000318511.3_Missense_Mutation_p.S442L|ILF3_ENST00000250241.8_Missense_Mutation_p.S442L	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	442	DRBM 1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GATGGCAATTCATTCGAGGCC	0.557000													7	77					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241953905	241953905	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:241953905G>A	ENST00000366552.2	+	24	3081	c.2874G>A	c.(2872-2874)atG>atA	p.M958I	WDR64_ENST00000437684.2_Missense_Mutation_p.M791I	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	958										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			GGAGAAAAATGAGCTCAGTGT	0.388000													18	239					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46658501	46658501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46658501C>T	ENST00000544460.1	+	1	2890	c.2636C>T	c.(2635-2637)gCt>gTt	p.A879V	TDRD6_ENST00000316081.6_Missense_Mutation_p.A879V	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	879					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AAGGCACAGGCTTTTAGGTGC	0.328000													42	131					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179452434	179452434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179452434C>T	ENST00000589042.1	-	306	63826	c.63602G>A	c.(63601-63603)cGa>cAa	p.R21201Q	TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R18633Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R19560Q|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R12328Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R12261Q|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R12136Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19560	Fibronectin type-III 54.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGGGCTGGTCGTCCTCTCAC	0.478000													15	33					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118360862	118360862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118360862C>T	ENST00000534358.1	+	13	4617	c.4594C>T	c.(4594-4596)Cgc>Tgc	p.R1532C	KMT2A_ENST00000354520.4_Missense_Mutation_p.R1494C|KMT2A_ENST00000389506.5_Missense_Mutation_p.R1532C	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CAAGTGTGTTCGCTGTAAGAG	0.383000													14	52					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123593738	123593738	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123593738C>T	ENST00000340011.5	+	3	471	c.114C>T	c.(112-114)ttC>ttT	p.F38F	SPAM1_ENST00000460182.1_Silent_p.F38F|SPAM1_ENST00000439500.1_Silent_p.F38F|SPAM1_ENST00000223028.7_Silent_p.F38F|SPAM1_ENST00000402183.2_Silent_p.F38F	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	38					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	CTCTGAATTTCAGAGCACCTC	0.413000													6	58					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100730827	100730827	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100730827C>T	ENST00000306085.6	+	3	531	c.234C>T	c.(232-234)ttC>ttT	p.F78F		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	78					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAACTTCTTCGTCAATGGGC	0.692000													45	78					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95058564	95058564	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95058564G>A	ENST00000329597.7	+	6	1419	c.1209G>A	c.(1207-1209)gtG>gtA	p.V403V	SERPINA5_ENST00000553780.1_Silent_p.V403V|SERPINA3_ENST00000553947.1_Intron|SERPINA5_ENST00000554866.1_Silent_p.V403V|SERPINA5_ENST00000554276.1_Silent_p.V403V	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	403					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	TTGGCAAAGTGAACCGCCCCT	0.532000													117	258					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32172034	32172034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32172034C>T	ENST00000375023.3	-	19	3136	c.2998G>A	c.(2998-3000)Ggg>Agg	p.G1000R		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1000	EGF-like 25.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						CAGCGTAGCCCCACAAAGCCT	0.592000													20	47					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848336	123848336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123848336C>T	ENST00000531945.1	-	1	152	c.63G>A	c.(61-63)gtG>gtA	p.V21V		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AGTGGCTCACCACAGTCTGGT	0.488000													31	76					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184293694	184293694	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184293694C>T	ENST00000330394.2	+	4	1385	c.933C>T	c.(931-933)acC>acT	p.T311T	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	311	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCCGTACCACCTCCCCAGCCG	0.617000													37	118					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41729504	41729504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:41729504G>A	ENST00000242208.4	-	3	1271	c.1025C>T	c.(1024-1026)cCc>cTc	p.P342L	INHBA_ENST00000464515.1_5'UTR|INHBA_ENST00000442711.1_Missense_Mutation_p.P342L|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	342					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						ATAGCCAGAGGGAGCAATGAT	0.537000										TSP Lung(11;0.080)			30	103					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17007100	17007100	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17007100C>T	ENST00000443236.1	-	41	5485	c.5454G>A	c.(5452-5454)ggG>ggA	p.G1818G	CPAMD8_ENST00000597335.1_5'UTR	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1771						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CCAGGTCATCCCCGTAGGTGG	0.692000													11	22					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31282318	31282318	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31282318C>T	ENST00000544665.3	+	6	542	c.471C>T	c.(469-471)ggC>ggT	p.G157G	ITGAM_ENST00000287497.8_Silent_p.G157G	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	157	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TGATTGATGGCTCTGGTAGCA	0.458000													59	218					0	0	1	0	0
SMOX	54498	broad.mit.edu	37	20	4162831	4162831	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:4162831C>T	ENST00000305958.4	+	5	930	c.705C>T	c.(703-705)atC>atT	p.I235I	SMOX_ENST00000379460.2_Silent_p.I235I|SMOX_ENST00000346595.2_Intron|SMOX_ENST00000339123.6_Silent_p.I235I|SMOX_ENST00000278795.3_Silent_p.I235I	NM_175839.1	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	235					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	ACCACATCATCCCCTCGGGCT	0.647000													28	42					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25307511	25307511	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25307511C>T	ENST00000549804.2	+	0	397				SNORD116-5_ENST00000384462.1_RNA																							TAAAAACATTCCTTGGAAAAG	0.507000													35	192					0	0	1	0	0
C5orf20	140947	broad.mit.edu	37	5	134782265	134782265	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134782265C>T	ENST00000503143.2	-	1	773	c.534G>A	c.(532-534)ctG>ctA	p.L178L	TIFAB_ENST00000537858.1_3'UTR	NM_130848.2	NP_570900.1	Q8TF63	DCNP1_HUMAN	chromosome 5 open reading frame 20	178	Ser-rich.					nucleus				endometrium(1)|lung(1)|prostate(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTGATGATTTCAGTGATTTTC	0.488000													27	80					0	0	1	0	0
CAPN12	147968	broad.mit.edu	37	19	39228192	39228192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39228192C>T	ENST00000328867.4	-	9	1360	c.1052G>A	c.(1051-1053)gGg>gAg	p.G351E	CAPN12_ENST00000601953.1_Missense_Mutation_p.G202E	NM_144691.3	NP_653292.2	Q6ZSI9	CAN12_HUMAN	calpain 12	351	Domain III.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CCAGCCGCCCCCCTCCGGGCT	0.692000													17	32					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154624622	154624622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:154624622G>A	ENST00000260010.6	+	1	1971	c.563G>A	c.(562-564)aGc>aAc	p.S188N		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	188					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				GATCTACAGAGCTATGAGCCA	0.368000													38	48					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982054	7982054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7982054C>T	ENST00000328600.2	-	2	1266	c.1105G>A	c.(1105-1107)Gag>Aag	p.E369K		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	369	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTGCCTCTCTCCATCTGCCCC	0.527000													16	38					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101887979	101887979	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101887979T>A	ENST00000398181.2	-	15	2172	c.1859A>T	c.(1858-1860)aAc>aTc	p.N620I	PCSK6_ENST00000344273.2_Missense_Mutation_p.E635D|PCSK6_ENST00000348070.1_Intron|PCSK6_ENST00000358417.3_Intron|PCSK6_ENST00000561177.1_Intron	NM_138323.1|NM_138325.2	NP_612196.1|NP_612198.2	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	621	Homo B/P.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ttagtccaggttccctggaaa	0.512000													32	95					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31302255	31302255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31302255G>A	ENST00000265071.2	+	6	1114	c.849G>A	c.(847-849)ccG>ccA	p.P283P	CDH6_ENST00000514738.1_Silent_p.P228P	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	283	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CTTCTCCACCGGGGACACCAA	0.423000													14	39					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196682553	196682553	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196682553C>T	ENST00000312428.6	-	50	9392	c.9291_splice	c.e50-1	p.V3098_splice		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3098	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATAATGTTACCTATAAATGA	0.338000													4	22					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	100996191	100996191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:100996191G>A	ENST00000284382.4	-	12	1329	c.906C>T	c.(904-906)atC>atT	p.I302I	CERS3_ENST00000394113.1_Silent_p.I302I|CERS3_ENST00000560944.1_Intron|CERS3_ENST00000538112.2_Silent_p.I302I	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	302	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GGTTGAGGAAGATGTATGAAA	0.398000													19	90					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56368991	56368991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56368991G>A	ENST00000587891.1	+	1	181	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K	NLRP4_ENST00000301295.6_Intron|NLRP4_ENST00000346986.5_Intron			Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	0	DAPIN.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ATATATGCAGGAATGCTTAAC	0.453000													11	27					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9045944	9045944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9045944G>A	ENST00000397910.4	-	5	35890	c.35687C>T	c.(35686-35688)tCc>tTc	p.S11896F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11898	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACAGCAGGGGAAACAGTCAG	0.488000													7	119					0	0	1	0	0
CHI3L2	1117	broad.mit.edu	37	1	111781455	111781455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111781455C>T	ENST00000445067.2	+	10	1590	c.819C>T	c.(817-819)ttC>ttT	p.F273F	CHI3L2_ENST00000524472.1_Silent_p.F194F|CHI3L2_ENST00000369744.2_Silent_p.F263F|CHI3L2_ENST00000369748.4_Silent_p.F273F|CHI3L2_ENST00000466741.1_Silent_p.F194F			Q15782	CH3L2_HUMAN	chitinase 3-like 2	273					chitin catabolic process	extracellular space	cation binding|chitinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(1)	19		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		GGCACTCCTTCACACTGGCCT	0.562000													64	167					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505221	37505221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37505221G>A	ENST00000374660.1	+	38	3270	c.3171G>A	c.(3169-3171)aaG>aaA	p.K1057K	ANKRD30A_ENST00000361713.1_Silent_p.K938K|ANKRD30A_ENST00000602533.1_Silent_p.K938K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1060						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AAATGAAAAAGAAGTTTTGTG	0.338000													13	75					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21211172	21211172	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21211172C>T	ENST00000574002.1	-	16	2204	c.1722G>A	c.(1720-1722)caG>caA	p.Q574Q	ZP2_ENST00000219593.4_Silent_p.Q574Q|ZP2_ENST00000574091.1_Silent_p.Q565Q|AF001550.7_ENST00000572747.1_RNA			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	574	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		GGAAGGTGGTCTGGTAGTTGT	0.493000													15	66					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23865624	23865624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23865624G>A	ENST00000405093.3	-	20	2368	c.2298C>T	c.(2296-2298)ttC>ttT	p.F766F	MYH6_ENST00000356287.3_Silent_p.F766F	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	766	Actin-binding.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CTGCCTTGAAGAACACCTGCA	0.642000													11	34					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168176541	168176541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168176541C>T	ENST00000519560.1	-	19	2492	c.2073G>A	c.(2071-2073)caG>caA	p.Q691Q	SLIT3_ENST00000332966.8_Silent_p.Q691Q|SLIT3_ENST00000404867.3_Silent_p.Q691Q	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	691	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAATGGCTTCTGGCACCTAG	0.572000													38	81					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29275004	29275004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29275004C>T	ENST00000377160.2	+	1	602	c.538C>T	c.(538-540)Cct>Tct	p.P180S		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						CTGTGATGTTCCTCAGATGCT	0.453000													36	154					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227898144	227898144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227898144C>T	ENST00000396625.3	-	38	3766	c.3559G>A	c.(3559-3561)Gga>Aga	p.G1187R	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1187R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1187	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTTTAGTTCCTTTCTGACCT	0.512000											OREG0015250	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	38					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102309921	102309921	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:102309921C>T	ENST00000438793.3	+	14	1734	c.1264C>T	c.(1264-1266)Ctg>Ttg	p.L422L	PAM_ENST00000346918.2_Silent_p.L422L|PAM_ENST00000455264.2_Silent_p.L422L|PAM_ENST00000304400.7_Silent_p.L422L|PAM_ENST00000274392.9_Silent_p.L325L|PAM_ENST00000379787.4_5'UTR|PAM_ENST00000348126.2_Intron	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	422	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	AGAGTCAGACCTGGTAGCTGA	0.423000													17	73					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38835841	38835841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38835841C>T	ENST00000359357.3	+	46	6300	c.6046C>T	c.(6046-6048)Cat>Tat	p.H2016Y	DNAH8_ENST00000441566.1_Missense_Mutation_p.H1980Y|DNAH8_ENST00000449981.2_Missense_Mutation_p.H2233Y					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATCTCAGGTTCATTATGACTT	0.373000													21	75					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539691	94539691	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94539691G>A	ENST00000289495.5	+	1	482	c.266G>A	c.(265-267)gGg>gAg	p.G89E	PPP1R9A_ENST00000424654.1_Missense_Mutation_p.G89E|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.G89E|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.G89E|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.G89E|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.G89E	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	89	Actin-binding.					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAACAAGGGGGAAAGGTGGA	0.418000										HNSCC(28;0.073)			23	36					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66223165	66223165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:66223165C>T	ENST00000409699.2	-	11	1576	c.1404G>A	c.(1402-1404)aaG>aaA	p.K468K	MEGF11_ENST00000395625.2_Silent_p.K393K|MEGF11_ENST00000395614.1_5'UTR|MEGF11_ENST00000360698.4_Silent_p.K468K|MEGF11_ENST00000288745.3_Silent_p.K393K|MEGF11_ENST00000422354.1_Silent_p.K468K			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	468	EGF-like 8.					basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						CATTACCTTCCTTGCAGGTAC	0.587000													54	78					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100348997	100348997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100348997G>A	ENST00000437033.2	-	5	1000	c.497C>T	c.(496-498)cCt>cTt	p.P166L	ADH7_ENST00000209665.4_Missense_Mutation_p.P178L|ADH7_ENST00000482593.1_Missense_Mutation_p.P109L|ADH7_ENST00000476959.1_Missense_Mutation_p.P186L			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	178					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	GACTTTCTCAGGAGGAGCTGC	0.443000													15	62					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87970614	87970614	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:87970614C>G	ENST00000369577.3	+	8	7310	c.7267C>G	c.(7267-7269)Ctt>Gtt	p.L2423V	ZNF292_ENST00000339907.4_Missense_Mutation_p.L2418V	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ACACCGAAATCTTCTTATTGT	0.353000													7	11					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	619829	619829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:619829C>T	ENST00000255622.6	+	1	457	c.414C>T	c.(412-414)gtC>gtT	p.V138V	PDE6B_ENST00000496514.1_Silent_p.V138V	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	138	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						ACATCGGGGTCGTGGGCCACG	0.647000													6	9					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87040429	87040429	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87040429A>T	ENST00000370563.3	+	10	1716	c.1674A>T	c.(1672-1674)ggA>ggT	p.G558G	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	558						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GTATTCCAGGAACTGCAAAGG	0.383000													12	62					0	0	1	0	0
LOC101927958	101927958	broad.mit.edu	37	2	239141393	239141393	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239141393G>A	ENST00000456601.1	+	0	906																											GCCAGCCAGCGAAGCAGCCAG	0.532000													9	20					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161292786	161292786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:161292786C>T	ENST00000428797.2	+	5	602	c.247C>T	c.(247-249)Cat>Tat	p.H83Y	GABRA1_ENST00000023897.6_Missense_Mutation_p.H83Y|GABRA1_ENST00000437025.2_Missense_Mutation_p.H83Y|GABRA1_ENST00000420560.1_Missense_Mutation_p.H83Y|GABRA1_ENST00000444819.1_Missense_Mutation_p.H83Y|GABRA1_ENST00000393943.4_Missense_Mutation_p.H83Y	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	83					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CGTTTCAGACCATGATATGGT	0.388000													52	136					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175836	143175836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143175836C>T	ENST00000408916.1	+	1	871	c.871C>T	c.(871-873)Cga>Tga	p.R291*	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	291					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					CCTCAAGCTTCGAAGCGTGTT	0.502000													21	57					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72840925	72840925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72840925G>A	ENST00000377182.4	+	14	2655	c.2038G>A	c.(2038-2040)Gac>Aac	p.D680N	SMC5-AS1_ENST00000594708.1_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	680						endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						ATATTCTGAGGACTTAAATGA	0.274000													14	68					0	0	1	0	0
GSTA3	2940	broad.mit.edu	37	6	52764831	52764831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52764831C>T	ENST00000211122.3	-	5	380	c.315G>A	c.(313-315)atG>atA	p.M105I	GSTA3_ENST00000370968.1_Missense_Mutation_p.M55I	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	105	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	GAAGAAGGATCATTTCATTCA	0.383000													61	188					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55142266	55142266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55142266C>T	ENST00000370862.3	+	5	1187	c.851C>T	c.(850-852)tCc>tTc	p.S284F		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	284					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCAACGAAGTCCCGGATGAGC	0.502000													13	46					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25514967	25514967	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25514967G>A	ENST00000554726.1	+	0	47				SNHG14_ENST00000452731.1_RNA|SNORD115-48_ENST00000364764.1_RNA																							GAGAAATGATGACGTAAAAAT	0.423000													24	59					0	0	1	0	0
PTGIR	5739	broad.mit.edu	37	19	47124812	47124812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47124812G>A	ENST00000291294.2	-	3	1019	c.886C>T	c.(886-888)Cgc>Tgc	p.R296C	PTGIR_ENST00000597185.1_Missense_Mutation_p.R25C|PTGIR_ENST00000598865.1_Missense_Mutation_p.R84C|PTGIR_ENST00000594275.1_Missense_Mutation_p.R53C	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	296					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	ACAGCCTTGCGGAAAAGGATG	0.637000													22	64					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119045960	119045960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119045960C>T	ENST00000409109.1	+	6	2235	c.1648C>T	c.(1648-1650)Cct>Tct	p.P550S	NLRX1_ENST00000409991.1_Missense_Mutation_p.P550S|NLRX1_ENST00000409265.4_Missense_Mutation_p.P550S|NLRX1_ENST00000292199.2_Missense_Mutation_p.P550S|NLRX1_ENST00000525863.1_Missense_Mutation_p.P550S			Q86UT6	NLRX1_HUMAN	NLR family member X1	550	Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCGGGCTCTGCCTCTGCTCTT	0.627000													35	66					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36091363	36091363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:36091363G>A	ENST00000378660.1	+	4	486	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	CHDC2_ENST00000313548.4_Missense_Mutation_p.E100K					calponin homology domain containing 2																		TTCTCTTGAGGAAGGAACAAA	0.413000													40	46					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139113755	139113755	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139113755G>A	ENST00000358701.5	-	6	745	c.708C>T	c.(706-708)atC>atT	p.I236I		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	236					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		GGGTCACCACGATGCTTTCAT	0.512000													27	74					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17482038	17482038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17482038G>A	ENST00000302539.4	-	6	1133	c.1008C>T	c.(1006-1008)ccC>ccT	p.P336P	ABCC8_ENST00000389817.3_Silent_p.P336P	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	336	ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGCCTACCTTGGGCTGGAAGA	0.582000													42	109					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130765006	130765006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:130765006G>A	ENST00000276708.4	-	7	1663	c.782C>T	c.(781-783)tCa>tTa	p.S261L		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	261						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						ggtatgaaatgatggtagcaa	0.433000													7	80					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189705318	189705318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189705318C>T	ENST00000319332.5	-	5	1293	c.1096G>A	c.(1096-1098)Gag>Aag	p.E366K	LEPREL1_ENST00000427335.2_Missense_Mutation_p.E185K	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	366					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGTCTCACCTCTCTGGCCTCA	0.418000													18	30					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54798330	54798330	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54798330C>T	ENST00000474759.1	+	13	1380	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	CACNA2D3_ENST00000490478.1_Silent_p.I350I|CACNA2D3_ENST00000288197.5_Silent_p.I444I|CACNA2D3_ENST00000415676.2_Silent_p.I444I	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	444						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CCAAAGTCATCGACCAGGAGC	0.522000													40	86					0	0	1	0	0
MIP	4284	broad.mit.edu	37	12	56847477	56847477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56847477G>A	ENST00000257979.4	-	2	451	c.423C>T	c.(421-423)ttC>ttT	p.F141F	MIP_ENST00000555551.1_5'UTR	NM_012064.3	NP_036196.1	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	141					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	16						TGCAGAGCACGAACTGGAGCG	0.607000													19	27					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151156369	151156369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151156369G>A	ENST00000282466.3	-	6	5979	c.5980C>T	c.(5980-5982)Cac>Tac	p.H1994Y	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1994	Ig-like C2-type 6.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGGTAGACGTGGATCCAGCTG	0.458000													15	43					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49219042	49219042	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49219042G>A	ENST00000327979.2	-	13	1625	c.1214C>T	c.(1213-1215)tCc>tTc	p.S405F	FAM65C_ENST00000045083.2_Missense_Mutation_p.S405F|FAM65C_ENST00000535356.1_Missense_Mutation_p.S409F			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	405										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGAGCTGAAGGAGTCCATCTC	0.637000													20	67					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784685	9784685	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9784685C>T	ENST00000304374.2	+	1	1428	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	344					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TCGACGTCTTCGTCTGGTTCG	0.592000													19	138					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19516253	19516253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:19516253C>T	ENST00000341998.2	-	10	1945	c.1884G>A	c.(1882-1884)atG>atA	p.M628I	SLC24A2_ENST00000286344.3_Missense_Mutation_p.M611I	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	628					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGATTTTGTTCATTCGCCACT	0.502000													60	88					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166179783	166179783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166179783G>A	ENST00000357398.3	+	12	2079	c.1789G>A	c.(1789-1791)Gag>Aag	p.E597K	SCN2A_ENST00000375437.2_Missense_Mutation_p.E597K|SCN2A_ENST00000375427.2_Missense_Mutation_p.E597K|SCN2A_ENST00000283256.6_Missense_Mutation_p.E597K			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	597					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TGCTGATGATGAGCACAGCAC	0.547000													16	59					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124623552	124623552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124623552G>A	ENST00000278927.5	-	7	1292	c.1163C>T	c.(1162-1164)tCt>tTt	p.S388F	ESAM_ENST00000442070.2_Intron	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	388					blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		TCATACCAGAGAGCCAGCTTG	0.557000													27	49					0	0	1	0	0
MTRF1	9617	broad.mit.edu	37	13	41814411	41814411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:41814411G>A	ENST00000379480.4	-	6	956	c.856C>T	c.(856-858)Cct>Tct	p.P286S	MTRF1_ENST00000379477.1_Missense_Mutation_p.P286S|MTRF1_ENST00000430347.2_Missense_Mutation_p.P299S	NM_004294.2	NP_004285.2	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	286					regulation of translational termination	mitochondrion	translation release factor activity, codon specific			breast(1)|endometrium(4)|large_intestine(3)|lung(6)	14		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		TCTGGCTGAGGAAGGACAATA	0.532000													35	110					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28540967	28540967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28540967G>A	ENST00000452236.2	-	4	3316	c.2699C>T	c.(2698-2700)tCa>tTa	p.S900L		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	900					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						aagttgcaatgaaaaatactt	0.333000													19	61					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841080	13841080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13841080C>T	ENST00000265104.4	-	34	5748	c.5644G>A	c.(5644-5646)Gaa>Aaa	p.E1882K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1882	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTCACTCGTTCCGTGGAACTC	0.398000									Kartagener syndrome				17	84					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179583227	179583227	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179583227C>T	ENST00000589042.1	-	85	24830	c.24606G>A	c.(24604-24606)gtG>gtA	p.V8202V	TTN_ENST00000342992.6_Silent_p.V6958V|TTN_ENST00000591111.1_Silent_p.V7885V|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7885	Ig-like 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTATCCAGCTCACTGAGATTG	0.428000													8	58					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149882491	149882491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149882491G>A	ENST00000369146.3	-	4	1332	c.842C>T	c.(841-843)tCc>tTc	p.S281F	SV2A_ENST00000369145.1_Missense_Mutation_p.S281F	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	281					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CAGAAACTCGGAGAAATAGGA	0.527000													7	58					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032408	30032408	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30032408C>T	ENST00000328224.6	-	2	3051	c.1818G>A	c.(1816-1818)ggG>ggA	p.G606G		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	606						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CTGACTTGTCCCCCAGGGAAG	0.468000													29	57					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926258	70926258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70926258G>A	ENST00000603540.1	+	2	2300	c.2042G>A	c.(2041-2043)gGa>gAa	p.G681E	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Missense_Mutation_p.G681E	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	681					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCAAAGAGAGGAGTTTTTTTG	0.488000													23	34					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58231851	58231851	+	Nonstop_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58231851A>T	ENST00000317398.6	-	4	1698	c.1603T>A	c.(1603-1605)Taa>Aaa	p.*535K	ZNF671_ENST00000335820.3_Nonstop_Mutation_p.*437K|AC003006.7_ENST00000599221.1_Intron	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTACACTCTTAAAGCTTTTCT	0.483000													224	394					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74452068	74452068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74452068C>T	ENST00000394019.2	-	28	3542	c.3145G>A	c.(3145-3147)Gac>Aac	p.D1049N	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000359484.4_Missense_Mutation_p.D947N|SLC4A5_ENST00000358683.4_Missense_Mutation_p.D947N|SLC4A5_ENST00000357822.5_Missense_Mutation_p.D1065N|SLC4A5_ENST00000346834.4_Missense_Mutation_p.D968N|SLC4A5_ENST00000377634.4_Missense_Mutation_p.D1065N|SLC4A5_ENST00000377632.1_Missense_Mutation_p.D968N|SLC4A5_ENST00000423644.1_Missense_Mutation_p.R989Q|SLC4A5_ENST00000483195.1_5'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1065						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CAGGCCAGGTCGTGCTGGGAA	0.473000													28	81					0	0	1	0	0
SIGLEC14	100049587	broad.mit.edu	37	19	52146630	52146630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52146630C>T	ENST00000360844.6	-	7	1210	c.1169G>A	c.(1168-1170)aGc>aAc	p.S390N	SIGLEC5_ENST00000599649.1_Intron|SIGLEC5_ENST00000429354.3_Intron|SIGLEC5_ENST00000534261.2_Intron|SIGLEC5_ENST00000222107.4_Intron	NM_001098612.1	NP_001092082.1	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14	390					cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		CTCAGCCCTGCTCTGCTGGGG	0.607000													6	62					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140189125	140189125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140189125C>T	ENST00000530339.1	+	1	2353	c.2353C>T	c.(2353-2355)Cag>Tag	p.Q785*	PCDHA4_ENST00000512229.2_Nonsense_Mutation_p.Q785*|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Nonsense_Mutation_p.Q785*|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGAAGATCAGCTGCAGAC	0.468000													16	170					0	0	1	0	0
IFI27	3429	broad.mit.edu	37	14	94578046	94578046	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94578046C>T	ENST00000555744.1	+	2	206	c.18C>T	c.(16-18)ctC>ctT	p.L6L	IFI27_ENST00000298902.5_Silent_p.L6L|IFI27_ENST00000448882.1_Silent_p.L6L|IFI27_ENST00000557098.1_Intron|IFI27_ENST00000557634.1_Silent_p.L6L|IFI27_ENST00000444961.1_Silent_p.L6L			P40305	IFI27_HUMAN	interferon, alpha-inducible protein 27	6					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion				breast(1)|lung(3)	4				Epithelial(152;0.112)|all cancers(159;0.187)|COAD - Colon adenocarcinoma(157;0.206)		CCTCTGCTCTCACCTCATCAG	0.597000													11	74					0	0	1	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3395114	3395114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3395114G>A	ENST00000378378.4	+	12	2157	c.1752G>A	c.(1750-1752)caG>caA	p.Q584Q	ARHGEF16_ENST00000378373.1_Silent_p.Q296Q|ARHGEF16_ENST00000378371.2_Silent_p.Q296Q|ARHGEF16_ENST00000413250.2_Silent_p.Q288Q	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	584	PH.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		ACCCCTTCCAGGTGACCCTGC	0.672000													34	60					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233393	21233393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21233393C>T	ENST00000233242.1	-	26	6474	c.6347G>A	c.(6346-6348)gGa>gAa	p.G2116E		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2116	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGGAGTTTTCCCAGGGCTGC	0.383000													17	44					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086661	39086661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39086661C>T	ENST00000400482.3	-	3	1388	c.799G>A	c.(799-801)Ggg>Agg	p.G267R	KCNJ6_ENST00000288309.6_Missense_Mutation_p.G267R	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	267					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CGGTCATCCCCCGTGTAATAC	0.507000													46	98					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41748899	41748899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41748899G>A	ENST00000301178.4	+	11	1614	c.1424G>A	c.(1423-1425)cGa>cAa	p.R475Q	AXL_ENST00000359092.3_Missense_Mutation_p.R466Q|AXL_ENST00000593513.1_Missense_Mutation_p.R207Q	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	475						integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GTCCACCGGCGAAAGAAGGAG	0.607000													19	53					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982673	36982673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36982673G>A	ENST00000274963.8	+	8	1059	c.888G>A	c.(886-888)cgG>cgA	p.R296R		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	296					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						CCTAGGAGCGGCTGCAGGACC	0.642000													17	48					0	0	1	0	0
TLE2	7089	broad.mit.edu	37	19	3005791	3005791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3005791G>A	ENST00000262953.6	-	16	1938	c.1676C>T	c.(1675-1677)gCc>gTc	p.A559V	TLE2_ENST00000591529.1_Missense_Mutation_p.A573V|TLE2_ENST00000590536.1_Missense_Mutation_p.A560V|TLE2_ENST00000586422.1_Intron|TLE2_ENST00000455444.2_Missense_Mutation_p.A437V|TLE2_ENST00000447365.2_Missense_Mutation_p.A226V|TLE2_ENST00000443826.3_Missense_Mutation_p.A437V|TLE2_ENST00000426948.2_Missense_Mutation_p.A573V	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	559					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAAACCTTGGCGTCGGGGCT	0.637000													7	59					0	0	1	0	0
POC5	134359	broad.mit.edu	37	5	75008689	75008689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75008689G>A	ENST00000428202.2	-	2	263	c.74C>T	c.(73-75)tCg>tTg	p.S25L	POC5_ENST00000514838.2_Missense_Mutation_p.S25L|POC5_ENST00000380475.2_5'UTR	NM_001099271.1	NP_001092741.1	Q8NA72	POC5_HUMAN	POC5 centriolar protein	25					cell cycle	centriole				breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CTGAAGATTCGAAGAGACAGA	0.323000													5	19					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759682	6759682	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6759682G>A	ENST00000378827.4	+	3	2356	c.1137G>A	c.(1135-1137)aaG>aaA	p.K379K		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	379					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	AGAATGAAAAGGTTGTATTAA	0.373000													19	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179476172	179476172	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179476172C>T	ENST00000589042.1	-	269	51008	c.50784G>A	c.(50782-50784)gtG>gtA	p.V16928V	TTN_ENST00000342992.6_Silent_p.V14360V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.V15287V|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Silent_p.V8055V|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.V7988V|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V7863V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15287	Fibronectin type-III 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGACTGCTCTCACTCTCAGGA	0.418000													18	88					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347850	91347850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91347850C>T	ENST00000358859.2	-	1	1103	c.670G>A	c.(670-672)Gag>Aag	p.E224K	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		GGGGAGGCCTCGCCGCTCACC	0.622000													47	170					0	0	1	0	0
LACC1	144811	broad.mit.edu	37	13	44464388	44464388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:44464388C>T	ENST00000441843.1	+	6	1757	c.1272C>T	c.(1270-1272)ggC>ggT	p.G424G	LACC1_ENST00000325686.6_Silent_p.G424G	NM_001128303.1	NP_001121775.1	Q8IV20	CM031_HUMAN	laccase (multicopper oxidoreductase) domain containing 1	424																	CACAGATTGGCTTCATATCAA	0.438000													20	64					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104895	183104895	+	Missense_Mutation	SNP	C	C	T	rs145482728		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:183104895C>T	ENST00000435564.1	-	3	540	c.340G>A	c.(340-342)Gaa>Aaa	p.E114K	PDE1A_ENST00000536095.1_Missense_Mutation_p.E10K|PDE1A_ENST00000409365.1_Missense_Mutation_p.E98K|PDE1A_ENST00000456212.1_Missense_Mutation_p.E114K|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Missense_Mutation_p.E114K|PDE1A_ENST00000358139.2_Missense_Mutation_p.E114K|PDE1A_ENST00000351439.5_Missense_Mutation_p.E98K|PDE1A_ENST00000331935.6_Missense_Mutation_p.E114K|PDE1A_ENST00000346717.4_Missense_Mutation_p.E80K	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	114					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.E114K(1)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTTGGTTTTTCCTCAGGTTTC	0.418000													31	111					0	0	1	0	0
STK26	51765	broad.mit.edu	37	X	131202542	131202542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:131202542G>A	ENST00000394334.2	+	6	795	c.542G>A	c.(541-543)gGa>gAa	p.G181E	MST4_ENST00000496850.1_Missense_Mutation_p.G181E|MST4_ENST00000394335.2_Missense_Mutation_p.G104E|MST4_ENST00000354719.6_Missense_Mutation_p.G181E|MST4_ENST00000481105.1_Missense_Mutation_p.G203E	NM_016542.3	NP_057626.2	Q9P289	MST4_HUMAN		181	Protein kinase.				cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(192;0.000127)					ACCTTTGTGGGAACTCCATTT	0.378000													31	53					0	0	1	0	0
BABAM1	29086	broad.mit.edu	37	19	17382414	17382414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17382414C>T	ENST00000359435.4	+	3	487	c.294C>T	c.(292-294)tgC>tgT	p.C98C	BABAM1_ENST00000598188.1_Silent_p.C98C|BABAM1_ENST00000447614.2_Silent_p.C98C|CTD-2278I10.6_ENST00000596542.1_Intron|BABAM1_ENST00000601043.1_Silent_p.C98C|BABAM1_ENST00000448635.2_3'UTR|BABAM1_ENST00000595632.1_Silent_p.C98C	NM_001033549.1	NP_001028721.1	Q9NWV8	BABA1_HUMAN	BRISC and BRCA1 A complex member 1	98	VWFA-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|protein K63-linked deubiquitination|response to ionizing radiation	BRCA1-A complex|BRISC complex|cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5						AGATTATCTGCCTGGACCTGT	0.547000													9	21					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117609777	117609777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117609777C>T	ENST00000368508.3	-	43	7120	c.6922G>A	c.(6922-6924)Gaa>Aaa	p.E2308K	ROS1_ENST00000368507.3_Missense_Mutation_p.E2302K	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2308					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.E2308Q(2)	TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCATGTGGTTCCTTCTCTTCT	0.483000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								28	34					0	0	1	0	0
TSPAN12	23554	broad.mit.edu	37	7	120428804	120428804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120428804C>T	ENST00000222747.3	-	8	1367	c.760G>A	c.(760-762)Gag>Aag	p.E254K	TSPAN12_ENST00000415871.1_Missense_Mutation_p.E254K	NM_012338.3	NP_036470.1	O95859	TSN12_HUMAN	tetraspanin 12	254					angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction				endometrium(3)|kidney(1)|lung(4)|ovary(1)|skin(1)	10	all_neural(327;0.117)					GTCCCCGGCTCCCTTCTATCA	0.483000													29	81					0	0	1	0	0
GSX2	170825	broad.mit.edu	37	4	54966673	54966673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:54966673G>A	ENST00000326902.2	+	1	476	c.162G>A	c.(160-162)aaG>aaA	p.K54K	FIP1L1_ENST00000507166.1_Intron|GSX2_ENST00000503800.1_Silent_p.K54K	NM_133267.2	NP_573574.1	Q9BZM3	GSX2_HUMAN	GS homeobox 2	54						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(2)|lung(2)	6	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			CGTCCCGCAAGAGCGGCGCGT	0.716000													12	20					0	0	1	0	0
AGBL2	79841	broad.mit.edu	37	11	47721096	47721096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47721096G>A	ENST00000525123.1	-	8	881	c.596C>T	c.(595-597)cCa>cTa	p.P199L	AGBL2_ENST00000357610.3_Missense_Mutation_p.P199L|AGBL2_ENST00000298861.4_Missense_Mutation_p.P199L|AGBL2_ENST00000528244.1_Missense_Mutation_p.P161L|AGBL2_ENST00000529712.1_5'UTR	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	199					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						TGGTTGAGGTGGAGCCCACTC	0.303000													17	34					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316279	30316279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30316279C>T	ENST00000375377.1	-	3	2899	c.2798G>A	c.(2797-2799)gGc>gAc	p.G933D		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	933										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						GCGAAAGCGGCCCGGGGATGG	0.607000													10	72					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234106900	234106900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234106900C>T	ENST00000359570.5	+	27	2817	c.2817C>T	c.(2815-2817)tcC>tcT	p.S939S	INPP5D_ENST00000455936.2_Silent_p.S703S|INPP5D_ENST00000450745.1_Silent_p.S703S			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	951	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CCAAGGACTCCCCGCTGGGGC	0.647000													19	59					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164271863	164271863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164271863C>T	ENST00000515560.1	+	4	1960	c.438C>T	c.(436-438)ccC>ccT	p.P146P	NPY5R_ENST00000506953.1_Silent_p.P146P|NPY5R_ENST00000338566.3_Silent_p.P146P			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	146					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				TAAAACATCCCATATCTAATA	0.363000													70	174					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179452474	179452474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179452474C>T	ENST00000589042.1	-	306	63786	c.63562G>A	c.(63562-63564)Gca>Aca	p.A21188T	TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.A18620T|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.A19547T|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.A12315T|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.A12248T|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.A12123T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19547	Fibronectin type-III 53.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCATCCTGCTCTCACTATG	0.443000													12	36					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20140998	20140998	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20140998G>A	ENST00000375121.2	-	1	773	c.597C>T	c.(595-597)ctC>ctT	p.L199L	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	199						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGGTGCTGGGGAGACAGCAGA	0.592000													9	44					0	0	1	0	0
XKR8	55113	broad.mit.edu	37	1	28290032	28290032	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28290032G>A	ENST00000373884.5	+	2	926	c.318G>A	c.(316-318)ggG>ggA	p.G106G		NM_018053.2	NP_060523.2	Q9H6D3	XKR8_HUMAN	XK, Kell blood group complex subunit-related family, member 8	106						integral to membrane				endometrium(1)|large_intestine(2)|lung(1)	4		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;4.72e-24)|Colorectal(126;1.52e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00572)|READ - Rectum adenocarcinoma(331;0.0526)		TGCGGCAGGGGCTGCTGGTGT	0.602000													17	40					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26096140	26096140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26096140G>A	ENST00000313735.6	-	17	2130	c.1897C>T	c.(1897-1899)Cgg>Tgg	p.R633W		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	633	Flavodoxin-like.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GCGCAGAACCGAGGGTACATG	0.607000													4	22					0	0	1	0	0
SOX7	83595	broad.mit.edu	37	8	10583561	10583561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10583561G>A	ENST00000304501.1	-	2	932	c.854C>T	c.(853-855)tCc>tTc	p.S285F	SOX7_ENST00000554914.1_Missense_Mutation_p.S337F|SOX7_ENST00000553390.1_Missense_Mutation_p.S337F	NM_031439.2	NP_113627.1	Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	285	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding	p.S285F(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		GGTGGCCGGGGAGTAATAGGC	0.667000													15	29					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43045247	43045247	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43045247G>A	ENST00000267890.6	-	14	2305	c.2197C>T	c.(2197-2199)Cag>Tag	p.Q733*		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	733					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TGATCTATCTGAAGCCCCAAA	0.448000													18	204					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519762	69519762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69519762C>T	ENST00000338206.5	-	5	1315	c.1306G>A	c.(1306-1308)Gac>Aac	p.D436N		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	436					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CACACAGGGTCATTAATGACT	0.373000													69	165					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215852476	215852476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215852476G>A	ENST00000272895.7	-	27	4090	c.3871C>T	c.(3871-3873)Cct>Tct	p.P1291S	ABCA12_ENST00000389661.4_Missense_Mutation_p.P973S	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1291					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CAATAGGAAGGAAGAATTGGA	0.423000													6	33					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121356037	121356037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121356037C>T	ENST00000314583.3	-	7	612	c.521G>A	c.(520-522)gGa>gAa	p.G174E	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Intron	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	174					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		GTAGTCATATCCCAGAGCTGC	0.552000													7	122					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516601	140516601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140516601C>T	ENST00000231134.5	+	1	1802	c.1585C>T	c.(1585-1587)Cgc>Tgc	p.R529C		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		529	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding	p.R529C(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGAGTTCCGCGTGGGAGC	0.682000													55	88					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78380231	78380231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78380231C>T	ENST00000278550.7	-	32	7621	c.7159G>A	c.(7159-7161)Gag>Aag	p.E2387K		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		ATGTAGATCTCCCCATAGGCT	0.483000													4	32					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37903043	37903043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37903043G>A	ENST00000199447.4	+	8	805	c.433G>A	c.(433-435)Gaa>Aaa	p.E145K	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.E145K	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	145					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										AGTTAGTGAAGAATCACCATG	0.343000													24	105					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60193679	60193679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:60193679G>A	ENST00000267484.5	-	3	2058	c.1723C>T	c.(1723-1725)Cct>Tct	p.P575S		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	575					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GGGGCGCCAGGACCTAGAGGC	0.587000													12	12					0	0	1	0	0
POLR1E	64425	broad.mit.edu	37	9	37486584	37486584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37486584C>T	ENST00000377792.3	+	1	435	c.147C>T	c.(145-147)ttC>ttT	p.F49F	POLR1E_ENST00000442009.2_Intron|POLR1E_ENST00000377798.4_Intron			Q9GZS1	RPA49_HUMAN	polymerase (RNA) I polypeptide E, 53kDa	49					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding			autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|skin(1)|stomach(1)	12				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		ACCCGAGCTTCCTTGCCATCC	0.582000													11	11					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155018608	155018608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155018608G>A	ENST00000295542.1	+	12	1376	c.1280G>A	c.(1279-1281)cGg>cAg	p.R427Q	DCST1_ENST00000392480.1_Missense_Mutation_p.R427Q|DCST1_ENST00000368419.2_Missense_Mutation_p.R427Q|DCST1_ENST00000423025.2_Missense_Mutation_p.R402Q	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	427						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CAGGGCAAACGGACTCTGCTG	0.557000													22	74					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3888393	3888393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3888393G>A	ENST00000319331.3	+	2	2829	c.2068G>A	c.(2068-2070)Ggt>Agt	p.G690S	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	690						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCTCTGGGAAGGTGACAGCGA	0.423000													25	38					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176833426	176833426	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176833426C>T	ENST00000367654.2	-	23	3916	c.3903G>A	c.(3901-3903)gaG>gaA	p.E1301E	ASTN1_ENST00000367657.3_Intron|ASTN1_ENST00000361833.2_Silent_p.E1293E			O14525	ASTN1_HUMAN	astrotactin 1	1301					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GGTGCTAGATCTCTTTGCTGT	0.517000													60	131					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3047596	3047596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3047596C>T	ENST00000520002.1	-	35	5794	c.5239G>A	c.(5239-5241)Gag>Aag	p.E1747K	CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000542608.1_Missense_Mutation_p.E1746K|CSMD1_ENST00000400186.3_Missense_Mutation_p.E1747K|CSMD1_ENST00000602557.1_Missense_Mutation_p.E1747K|CSMD1_ENST00000537824.1_Missense_Mutation_p.E1746K|CSMD1_ENST00000602723.1_Missense_Mutation_p.E1747K|CSMD1_ENST00000539096.1_Missense_Mutation_p.E1746K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1747	Sushi 10.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TATCTGGGCTCGGGGACAGAG	0.557000													4	6					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12853596	12853596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12853596C>T	ENST00000332296.7	+	2	323	c.220C>T	c.(220-222)Cat>Tat	p.H74Y		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	74										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGACGCTTCATTTGGAGAC	0.557000													53	149					0	0	1	0	0
IFNA17	3451	broad.mit.edu	37	9	21227932	21227932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21227932G>A	ENST00000413767.2	-	1	289	c.241C>T	c.(241-243)Cat>Tat	p.H81Y		NM_021268.2	NP_067091.1	P01571	IFN17_HUMAN	interferon, alpha 17	81					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(2)|lung(4)|ovary(1)|skin(1)	9				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		ATCATCTCATGGAGGACAGAG	0.488000													51	111					0	0	1	0	0
SPATA4	132851	broad.mit.edu	37	4	177114160	177114160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:177114160C>T	ENST00000280191.2	-	3	524	c.416G>A	c.(415-417)gGa>gAa	p.G139E	SPATA4_ENST00000515234.1_5'UTR	NM_144644.2	NP_653245.2	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	139					apoptosis|spermatogenesis					NS(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)	22		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		TTCAGGCACTCCAGCTTTACA	0.284000													17	38					0	0	1	0	0
ATXN7	6314	broad.mit.edu	37	3	63967960	63967960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:63967960C>T	ENST00000398590.3	+	7	1404	c.851C>T	c.(850-852)tCc>tTc	p.S284F	ATXN7_ENST00000487717.1_Missense_Mutation_p.S284F|ATXN7_ENST00000295900.6_Missense_Mutation_p.S284F|ATXN7_ENST00000538065.1_Missense_Mutation_p.S284F|ATXN7_ENST00000488239.1_3'UTR|ATXN7_ENST00000484332.1_Missense_Mutation_p.S139F	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	284					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		ACTGTGAGTTCCTTAGTCAAG	0.517000													9	66					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47423320	47423320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47423320C>T	ENST00000361866.3	+	35	2594	c.2480C>T	c.(2479-2481)cCg>cTg	p.P827L	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	827	C-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	TTCTCCTCCCCGGCTGACATC	0.677000													7	62					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50366976	50366976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50366976G>A	ENST00000315520.5	+	1	357	c.20G>A	c.(19-21)gGg>gAg	p.G7E	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	7					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						GTGGAGCCAGGGGGACGTGGC	0.592000													8	43					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202400940	202400940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202400940G>A	ENST00000439140.1	-	13	1354	c.1310C>T	c.(1309-1311)cCt>cTt	p.P437L	ALS2CR11_ENST00000286195.3_Missense_Mutation_p.P437L|ALS2CR11_ENST00000450242.1_Missense_Mutation_p.P437L|ALS2CR11_ENST00000439802.1_Intron	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	437										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						TGTGGGTGAAGGTGTTGATTC	0.403000													58	114					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75036941	75036941	+	Missense_Mutation	SNP	C	C	T	rs139857791	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75036941C>T	ENST00000326665.5	-	14	4671	c.4453G>A	c.(4453-4455)Gaa>Aaa	p.E1485K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1485	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGACTCAATTCCCTCTCTCCC	0.542000													69	157					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167060583	167060583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167060583C>T	ENST00000375387.4	-	26	4999	c.4659G>A	c.(4657-4659)gtG>gtA	p.V1553V	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Silent_p.V1552V|SCN9A_ENST00000409672.1_Silent_p.V1541V|SCN9A_ENST00000303354.6_Silent_p.V1553V			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1552						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTATAAAAACCACATTTATCC	0.353000													5	57					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419919	130419919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130419919C>T	ENST00000370904.1	-	10	1084	c.174G>A	c.(172-174)aaG>aaA	p.K58K	IGSF1_ENST00000370910.1_Silent_p.K58K|IGSF1_ENST00000370903.3_Silent_p.K67K|IGSF1_ENST00000361420.3_Silent_p.K67K|IGSF1_ENST00000370900.1_Silent_p.K67K|IGSF1_ENST00000370901.4_Silent_p.K67K			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	67	Ig-like C2-type 1.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GCAGCAGGAACTTGCTTGATA	0.527000													48	55					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101344485	101344485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101344485G>A	ENST00000344327.3	-	7	2188	c.1764C>T	c.(1762-1764)ccC>ccT	p.P588P	TRPC6_ENST00000348423.4_Silent_p.P472P|TRPC6_ENST00000360497.4_Silent_p.P533P|TRPC6_ENST00000532133.1_Silent_p.P510P	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	588					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GAGGATCAGAGGGGTCCCACT	0.348000													54	98					0	0	1	0	0
ALPP	250	broad.mit.edu	37	2	233244485	233244485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233244485G>A	ENST00000392027.2	+	5	765	c.496G>A	c.(496-498)Gga>Aga	p.G166R	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	166						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GAAGTCAGTGGGAGTGGTAAC	0.632000													15	42					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79033081	79033081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79033081G>A	ENST00000446378.2	+	2	8524	c.8493G>A	c.(8491-8493)gtG>gtA	p.V2831V		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2831						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTAACGCAGTGAAGAAAAAAG	0.398000													18	44					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115829395	115829395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115829395G>A	ENST00000369512.2	-	3	190	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	8					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	GCTGTGATCAGAGTGTAGAAC	0.478000													34	80					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401432	77401432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77401432G>A	ENST00000282849.5	-	4	1102	c.684C>T	c.(682-684)tcC>tcT	p.S228S	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	228					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGTGACTTGGGGAGTAACCAG	0.517000													22	52					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34021740	34021740	+	Silent	SNP	C	C	T	rs146951838		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34021740C>T	ENST00000374372.1	-	4	1976	c.1473G>A	c.(1471-1473)gaG>gaA	p.E491E	GDF5OS_ENST00000374375.1_5'UTR|GDF5_ENST00000374369.3_Silent_p.E491E			P43026	GDF5_HUMAN	growth differentiation factor 5	491			E -> K (in SYM1).		cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CGACCATGTCCTCATACTGCT	0.587000													35	69					0	0	1	0	0
LDHD	197257	broad.mit.edu	37	16	75146541	75146541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:75146541C>T	ENST00000300051.4	-	10	1363	c.1317G>A	c.(1315-1317)gaG>gaA	p.E439E	LDHD_ENST00000450168.2_Silent_p.E416E	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	439							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding			endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						TGCCCAGTTCCTCGGCGTCAT	0.607000													16	36					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28861653	28861653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28861653C>T	ENST00000373833.6	+	8	818	c.533C>T	c.(532-534)gCc>gTc	p.A178V	RCC1_ENST00000429051.1_3'UTR|RCC1_ENST00000373831.3_Missense_Mutation_p.A209V|RCC1_ENST00000373832.1_Missense_Mutation_p.A178V|RCC1_ENST00000398958.2_Missense_Mutation_p.A178V			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	178					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GTAAAGGTGGCCTCAGGTGGG	0.582000													17	73					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154411258	154411258	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:154411258C>T	ENST00000414028.2	+	2	638	c.588C>T	c.(586-588)ctC>ctT	p.L196L	OPRM1_ENST00000428397.2_Silent_p.L196L|OPRM1_ENST00000229768.5_Silent_p.L196L|OPRM1_ENST00000435918.2_Silent_p.L196L|OPRM1_ENST00000522236.1_Silent_p.L96L|OPRM1_ENST00000524163.1_Silent_p.L196L|OPRM1_ENST00000452687.2_Silent_p.L196L|OPRM1_ENST00000330432.7_Silent_p.L196L|OPRM1_ENST00000360422.4_Silent_p.L196L|OPRM1_ENST00000434900.2_Silent_p.L289L|OPRM1_ENST00000520708.1_Silent_p.L96L|OPRM1_ENST00000337049.4_Silent_p.L196L|OPRM1_ENST00000518759.1_Silent_p.L115L|OPRM1_ENST00000419506.2_Silent_p.L196L|OPRM1_ENST00000522555.1_Silent_p.L96L	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	196					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	ACTGGATCCTCTCTTCAGCCA	0.473000													46	60					0	0	1	0	0
OTOR	56914	broad.mit.edu	37	20	16730641	16730641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:16730641G>A	ENST00000246081.2	+	3	393	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K	OTOR_ENST00000486129.1_3'UTR	NM_020157.2	NP_064542.1	Q9NRC9	OTOR_HUMAN	otoraplin	117					sensory perception of sound	extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|liver(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10						AGCTACCAAGGAAGTTCCCAC	0.488000													12	31					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18725187	18725187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18725187C>T	ENST00000440756.2	-	4	1733	c.1631G>A	c.(1630-1632)gGa>gAa	p.G544E	PSD3_ENST00000327040.8_Missense_Mutation_p.G544E|PSD3_ENST00000523619.1_Missense_Mutation_p.G479E			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	544	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CGAGTACCTTCCCCAGAAAGC	0.463000													19	51					0	0	1	0	0
LOC401127	401127	broad.mit.edu	37	4	39482942	39482942	+	RNA	SNP	A	A	C	rs10010309	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39482942A>C	ENST00000513652.1	+	0	949																											ACATCTGGAAACTTCAGACGA	0.453000													6	71					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106968913	106968913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:106968913C>T	ENST00000369066.3	+	2	3093	c.2606C>T	c.(2605-2607)tCc>tTc	p.S869F		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	869							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CAGAACGGTTCCCTATCTCAG	0.463000													34	58					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52842628	52842628	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52842628C>T	ENST00000449956.2	+	22	2610	c.2604C>T	c.(2602-2604)ttC>ttT	p.F868F	ITIH3_ENST00000416872.2_Silent_p.F676F	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	868					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TCTGCTGGTTCGTCCACAACA	0.532000													10	34					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386213	56386213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56386213G>A	ENST00000355701.3	-	22	5290	c.4420C>T	c.(4420-4422)Cgg>Tgg	p.R1474W	BZRAP1_ENST00000268893.6_Missense_Mutation_p.R1414W|BZRAP1_ENST00000343736.4_Missense_Mutation_p.R1474W	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1474						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGCACCTCCGGGAAGGGCCC	0.657000													13	26					0	0	1	0	0
HIATL1	84641	broad.mit.edu	37	9	97218585	97218585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:97218585C>T	ENST00000375344.3	+	10	1361	c.1092C>T	c.(1090-1092)gcC>gcT	p.A364A	HIATL1_ENST00000428393.2_Intron	NM_032558.2	NP_115947.2	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	364					transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	11		Acute lymphoblastic leukemia(62;0.136)				CAATCAGTGCCCTCGTCTCTC	0.582000													21	64					0	0	1	0	0
TOP2B	7155	broad.mit.edu	37	3	25674066	25674066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:25674066G>A	ENST00000435706.2	-	10	1323	c.1122C>T	c.(1120-1122)aaC>aaT	p.N374N	TOP2B_ENST00000264331.4_Silent_p.N379N			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa	379					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						CCCATATATGGTTTTTTACCT	0.299000													7	21					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45518302	45518302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45518302C>T	ENST00000291574.4	+	21	3408	c.3233C>T	c.(3232-3234)tCc>tTc	p.S1078F		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1078					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						AGAACAGGCTCCCTCTGCTCC	0.473000													56	159					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674183	4674183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4674183C>T	ENST00000396952.5	+	2	1077	c.427C>T	c.(427-429)Cgt>Tgt	p.R143C	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TACGTTGCCTCGTGTCACCAA	0.567000													33	72					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004702	52004702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52004702G>A	ENST00000291707.3	-	1	341	c.286C>T	c.(286-288)Ctt>Ttt	p.L96F		NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	96	Ig-like V-type 1.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGGTCCCCAAGGAGGTGGAAT	0.542000													39	161					0	0	1	0	0
ZNF8	7554	broad.mit.edu	37	19	58805736	58805736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58805736C>T	ENST00000196548.5	+	4	693	c.562C>T	c.(562-564)Cca>Tca	p.P188S	AC010642.1_ENST00000591325.1_3'UTR	NM_021089.2	NP_066575.2	P17098	ZNF8_HUMAN	zinc finger protein 8	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	19		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		GAGTTCAAGCCCAAATCCATT	0.448000													22	40					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3076448	3076448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3076448C>T	ENST00000397461.1	+	16	2300	c.1916C>T	c.(1915-1917)tCc>tTc	p.S639F	CNTN4_ENST00000397459.2_Missense_Mutation_p.S311F|CNTN4_ENST00000418658.1_Missense_Mutation_p.S639F|CNTN4_ENST00000427331.1_Missense_Mutation_p.S639F|CNTN4_ENST00000448906.2_Missense_Mutation_p.S311F|CNTN4_ENST00000358480.3_Missense_Mutation_p.S420F	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	639	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ACTCCATTCTCCGTGGGCTGG	0.537000													26	78					0	0	1	0	0
TRAV4	28689	broad.mit.edu	37	14	22204515	22204515	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22204515G>A	ENST00000390426.2	+	0	82																											GGCAAGTGGCGAGAGTGATCG	0.522000													5	11					0	0	1	0	0
CPA5	93979	broad.mit.edu	37	7	130007814	130007814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:130007814G>A	ENST00000485477.1	+	11	2235	c.1106G>A	c.(1105-1107)aGc>aAc	p.S369N	CPA5_ENST00000461828.1_Missense_Mutation_p.S369N|CPA5_ENST00000466363.2_Missense_Mutation_p.S369N|CPA5_ENST00000431780.2_Intron|CPA5_ENST00000474905.1_Missense_Mutation_p.S369N|CPA5_ENST00000393213.3_Missense_Mutation_p.S369N|CPA5_ENST00000355388.3_Missense_Mutation_p.S369N			Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5	369					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(2)|breast(2)|endometrium(2)|large_intestine(7)|lung(4)|ovary(3)|pancreas(1)|skin(2)	23	Melanoma(18;0.0435)					ATTTTTGGCAGCATCAGCACC	0.572000													20	53					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44843419	44843419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44843419C>T	ENST00000326047.4	+	13	1611	c.1462C>T	c.(1462-1464)Cgt>Tgt	p.R488C	KIF15_ENST00000425755.1_Missense_Mutation_p.R123C	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	488					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GGAGCAGGATCGTTTGCTCTC	0.378000													13	34					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86697680	86697680	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86697680G>A	ENST00000441037.2	+	3	239	c.144G>A	c.(142-144)aaG>aaA	p.K48K	AGBL1_ENST00000421325.2_Silent_p.K48K	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	48					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TTGGACGGAAGGCCCTAGAAT	0.448000													10	18					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68707096	68707096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68707096C>T	ENST00000255078.3	+	15	2990	c.2879C>T	c.(2878-2880)tCc>tTc	p.S960F		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	960					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding	p.S960F(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AAGAACGGATCCCTGGACCCA	0.657000													5	30					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21689995	21689995	+	Missense_Mutation	SNP	C	C	T	rs142656537	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21689995C>T	ENST00000261195.2	-	16	2259	c.2005G>A	c.(2005-2007)Gat>Aat	p.D669N		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	669					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TCTTCCTCATCGTATCTCTCA	0.483000													22	86					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8376633	8376633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8376633C>T	ENST00000538603.1	-	5	860	c.302G>A	c.(301-303)gGa>gAa	p.G101E	FAM90A1_ENST00000307435.6_Missense_Mutation_p.G101E	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	101							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		TTCCTTCTCTCCCTTATCCTT	0.537000													58	143					0	0	1	0	0
RBM23	55147	broad.mit.edu	37	14	23380554	23380554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23380554G>A	ENST00000359890.3	-	2	244	c.49C>T	c.(49-51)Ccc>Tcc	p.P17S	RBM23_ENST00000346528.5_Missense_Mutation_p.P17S|RBM23_ENST00000556984.1_5'UTR|RBM23_ENST00000555209.1_Intron|RBM23_ENST00000542016.2_5'UTR|RBM23_ENST00000399922.2_Missense_Mutation_p.P17S	NM_001077351.1	NP_001070819.1	Q86U06	RBM23_HUMAN	RNA binding motif protein 23	17					mRNA processing	nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|lung(3)|prostate(1)|skin(1)	10	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		TTTTTATAGGGAGCTTCCAGC	0.368000													49	207					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075259	76075259	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:76075259G>A	ENST00000395215.3	+	0	899																											GAGTTTGGAGGGAAAGCTCCA	0.577000													35	101					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735371	140735371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140735371C>T	ENST00000571252.1	+	1	604	c.604C>T	c.(604-606)Cgc>Tgc	p.R202C	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTCTAGATCGCGAGGAAGA	0.557000													11	16					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21306909	21306909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21306909G>A	ENST00000602326.1	-	8	847	c.264C>T	c.(262-264)ccC>ccT	p.P88P	EIF4G3_ENST00000356916.3_Silent_p.P92P|EIF4G3_ENST00000264211.8_Silent_p.P81P|EIF4G3_ENST00000374935.3_Silent_p.P81P|EIF4G3_ENST00000374937.3_Silent_p.P88P|EIF4G3_ENST00000374927.4_Silent_p.P81P|EIF4G3_ENST00000400422.1_Silent_p.P81P	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	81					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		ATTGTTGGGGGGGCCCAACAT	0.433000													9	29					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10927488	10927488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:10927488C>T	ENST00000283141.6	+	17	1624	c.1328C>T	c.(1327-1329)tCc>tTc	p.S443F	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	443						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GCAGAAGAATCCACTAACATG	0.448000													20	68					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784186	82784186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82784186G>A	ENST00000423517.2	-	2	2108	c.1771C>T	c.(1771-1773)Ctt>Ttt	p.L591F	PCLO_ENST00000333891.8_Missense_Mutation_p.L591F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	537	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTATTGCAAAGAGGACAGATG	0.453000													104	296					0	0	1	0	0
CACNG4	27092	broad.mit.edu	37	17	65026653	65026653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:65026653G>A	ENST00000262138.3	+	4	519	c.517G>A	c.(517-519)Gaa>Aaa	p.E173K		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	173					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			CAAGCGGGACGAAGACAAAAA	0.512000													43	110					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38925448	38925448	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38925448G>A	ENST00000274276.3	+	15	2589	c.2187G>A	c.(2185-2187)acG>acA	p.T729T		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	729	Fibronectin type-III 4.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					CTACGTTCACGAAGGTCACGA	0.433000													11	114					0	0	1	0	0
LCE2A	353139	broad.mit.edu	37	1	152671682	152671682	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152671682C>T	ENST00000368779.1	+	2	356	c.305C>T	c.(304-306)tCt>tTt	p.S102F		NM_178428.3	NP_848515.1	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	102	Cys-rich.				keratinization					breast(1)|large_intestine(1)|liver(2)|lung(4)	8	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCCACAGCTCTGGGGACTGC	0.602000													18	106					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24167407	24167407	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24167407G>A	ENST00000265769.4	+	3	261	c.150_splice	c.e3-1	p.E51_splice	ADAM28_ENST00000437154.2_Splice_Site_p.E51_splice|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_5'UTR|RP11-624C23.1_ENST00000523578.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	51					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATTTTTGCAGGAACAATTTGA	0.234000													17	112					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12725985	12725985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12725985C>T	ENST00000376221.1	+	4	463	c.463C>T	c.(463-465)Cct>Tct	p.P155S		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	155						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		CCGCAAGCTTCCTGACCACCA	0.522000													22	80					0	0	1	0	0
SKA3	221150	broad.mit.edu	37	13	21732064	21732064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:21732064G>A	ENST00000314759.5	-	7	1240	c.1116C>T	c.(1114-1116)ctC>ctT	p.L372L	SKA3_ENST00000400018.3_Silent_p.L372L	NM_145061.5	NP_659498.4	Q8IX90	SKA3_HUMAN	spindle and kinetochore associated complex subunit 3	372					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						AAATAACCTGGAGAATATCTT	0.313000													19	56					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28906923	28906923	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28906923C>T	ENST00000257192.4	+	3	383	c.171C>T	c.(169-171)gcC>gcT	p.A57A		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	57	Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TCGCAGCAGCCTGTCGTGAAG	0.398000													24	99					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25121451	25121451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25121451C>T	ENST00000332271.5	-	17	2484	c.2068G>A	c.(2068-2070)Gga>Aga	p.G690R	PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.G572R|PIWIL3_ENST00000533313.1_Missense_Mutation_p.G572R	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	690	Piwi.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						AGCTCTTCTCCTGTTTTCTGG	0.433000													9	137					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25341421	25341421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25341421G>A	ENST00000255324.5	+	2	194	c.142G>A	c.(142-144)Gaa>Aaa	p.E48K	RNF17_ENST00000255325.5_Missense_Mutation_p.E48K|RNF17_ENST00000255326.4_3'UTR|RNF17_ENST00000381921.1_Missense_Mutation_p.E48K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	48					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCACCATTGTGAACTTCAATG	0.358000													23	72					0	0	1	0	0
ZNF248	57209	broad.mit.edu	37	10	38127004	38127004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:38127004G>A	ENST00000395867.3	-	4	601	c.51C>T	c.(49-51)ttC>ttT	p.F17F	ZNF248_ENST00000374648.3_Silent_p.F17F|ZNF248_ENST00000357328.4_Silent_p.F17F|ZNF248_ENST00000494133.1_5'UTR	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						CTTCCTGAGTGAAGTCCACAC	0.383000													38	130					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150839020	150839020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150839020C>T	ENST00000397238.2	+	14	1840	c.1840C>T	c.(1840-1842)Ctc>Ttc	p.L614F	AGAP3_ENST00000463381.1_Missense_Mutation_p.L283F	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	578					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						GGTGGTGTCCCTCACTGGGCA	0.617000													8	94					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226026	158226026	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158226026C>T	ENST00000289429.5	+	3	1091	c.558C>T	c.(556-558)ttC>ttT	p.F186F		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	186	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GCCCACGTTTCATCTTGGGTC	0.463000													24	86					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156727806	156727806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156727806C>T	ENST00000347377.6	+	6	902	c.471C>T	c.(469-471)taC>taT	p.Y157Y	CYFIP2_ENST00000377576.3_Silent_p.Y157Y|CYFIP2_ENST00000318218.6_Silent_p.Y157Y|CYFIP2_ENST00000541131.1_Silent_p.Y82Y|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000521420.1_Silent_p.Y131Y|CYFIP2_ENST00000442283.2_5'UTR	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	157					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGAGGCCTACCTCCTGACCC	0.567000													13	25					0	0	1	0	0
CARS	833	broad.mit.edu	37	11	3040465	3040465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3040465G>A	ENST00000397114.3	-	12	1396	c.1020C>T	c.(1018-1020)gcC>gcT	p.A340A	CARS_ENST00000380525.4_Silent_p.A433A|CARS_ENST00000397111.5_Silent_p.A350A|CARS_ENST00000401769.3_Silent_p.A363A|CARS_ENST00000278224.9_Silent_p.A350A			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	350					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	TGCCTGCCATGGCCGAGCACT	0.597000			T	ALK	ALCL								34	128					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8421909	8421909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8421909G>A	ENST00000337907.3	-	18	2564	c.1930C>T	c.(1930-1932)Ctt>Ttt	p.L644F	RERE_ENST00000476556.1_Missense_Mutation_p.L90F|RERE_ENST00000377464.1_Missense_Mutation_p.L376F|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.L644F	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	644					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TTACTCTTAAGAGGGGAAGAG	0.552000													25	51					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899665	233899665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233899665C>T	ENST00000233840.3	+	2	1041	c.1041C>T	c.(1039-1041)tcC>tcT	p.S347S		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	347							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CTGATGGGTCCCCCTTGTTTG	0.587000													78	177					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314291	54314291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54314291C>T	ENST00000324134.6	-	3	790	c.622G>A	c.(622-624)Gag>Aag	p.E208K	NLRP12_ENST00000354278.3_Missense_Mutation_p.E208K|NLRP12_ENST00000391772.1_Missense_Mutation_p.E208K|NLRP12_ENST00000351894.4_Missense_Mutation_p.E208K|NLRP12_ENST00000391775.3_Missense_Mutation_p.E208K|NLRP12_ENST00000535162.1_Missense_Mutation_p.E208K|NLRP12_ENST00000345770.5_Missense_Mutation_p.E208K|NLRP12_ENST00000391773.1_Missense_Mutation_p.E208K	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	208					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CGCGGTGGCTCGGGGCGCTCC	0.647000													29	89					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234368445	234368445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234368445C>T	ENST00000264057.2	+	23	2749	c.2737C>T	c.(2737-2739)Cct>Tct	p.P913S	DGKD_ENST00000409813.3_Missense_Mutation_p.P869S	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	913					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	TGAGGGCGTGCCTGTGCAGGT	0.572000													19	33					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152193831	152193831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152193831C>T	ENST00000368801.2	-	3	349	c.274G>A	c.(274-276)Gat>Aat	p.D92N	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	92					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCAGTAATCTTTGCCAATG	0.413000													23	64					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21552453	21552453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:21552453G>A	ENST00000281523.2	-	4	857	c.339C>T	c.(337-339)gcC>gcT	p.A113A	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	113						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						TATTTTTCATGGCTTCCAGTG	0.468000													29	77					0	0	1	0	0
SH3RF3	344558	broad.mit.edu	37	2	110053528	110053528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:110053528C>T	ENST00000309415.6	+	7	1754	c.1754C>T	c.(1753-1755)tCg>tTg	p.S585L		NM_001099289.1	NP_001092759.1	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	585							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(5)|ovary(2)	18						CCCACAGCCTCGCCCCCAACA	0.682000													11	28					0	0	1	0	0
ANKRD13B	124930	broad.mit.edu	37	17	27935057	27935057	+	Missense_Mutation	SNP	C	C	T	rs148007819		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:27935057C>T	ENST00000394859.3	+	3	458	c.304C>T	c.(304-306)Cgg>Tgg	p.R102W	RP11-68I3.2_ENST00000581474.1_RNA	NM_152345.4	NP_689558.4	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	102										cervix(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	16						GCTGGTGCTTCGGTACCGGGA	0.682000													14	21					0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	354414	354414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:354414G>A	ENST00000262320.3	-	5	1515	c.1144C>T	c.(1144-1146)Cgc>Tgc	p.R382C	AXIN1_ENST00000354866.3_Missense_Mutation_p.R382C|AXIN1_ENST00000481769.1_5'UTR	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	382	Interaction with GSK3B (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.?(1)		biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GGCTCCACGCGGACCTCCTTC	0.632000													7	36					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46935494	46935494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46935494G>A	ENST00000313049.5	+	2	376	c.173G>A	c.(172-174)aGg>aAg	p.R58K	PTH1R_ENST00000430002.2_Missense_Mutation_p.R58K|PTH1R_ENST00000490109.1_3'UTR|PTH1R_ENST00000449590.1_Missense_Mutation_p.R58K|PTH1R_ENST00000418619.1_Missense_Mutation_p.R58K			Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	58						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						GTCCTGCAGAGGCCAGGTGGG	0.597000													5	31					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41465770	41465770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41465770G>A	ENST00000400454.1	-	21	4205	c.3728C>T	c.(3727-3729)tCg>tTg	p.S1243L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1243	Fibronectin type-III 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTAGGAAAACGAGTCGGGAGA	0.478000													19	49					0	0	1	0	0
FRRS1	391059	broad.mit.edu	37	1	100182983	100182983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100182983C>T	ENST00000414213.1	-	11	1820	c.1219G>A	c.(1219-1221)Gaa>Aaa	p.E407K	FRRS1_ENST00000287474.5_Missense_Mutation_p.E407K			Q6ZNA5	FRRS1_HUMAN	ferric-chelate reductase 1	407	Cytochrome b561.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	26		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		CAAGCTGCTTCACCAAGCAAG	0.403000													42	126					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103173923	103173923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103173923C>T	ENST00000375735.2	+	76	11341	c.11197C>T	c.(11197-11199)Cct>Tct	p.P3733S	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.P3740S	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3733	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GGGTGCTGATCCTTCTCAGGA	0.413000													14	46					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88853872	88853872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88853872G>A	ENST00000537554.1	-	2	4684	c.1122C>T	c.(1120-1122)ctC>ctT	p.L374L	CNR1_ENST00000549890.1_Silent_p.L374L|CNR1_ENST00000535130.1_Silent_p.L374L|CNR1_ENST00000369499.2_Silent_p.L374L|CNR1_ENST00000369501.2_Silent_p.L374L|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000428600.2_Silent_p.L374L|CNR1_ENST00000549716.1_Silent_p.L313L|CNR1_ENST00000468898.1_Silent_p.L341L	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	374					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CCGTCTTAATGAGCTTGTTCA	0.512000													31	52					0	0	1	0	0
RP11-407N17.3	0	broad.mit.edu	37	14	39717177	39717177	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:39717177C>T	ENST00000553728.1	+	4	1612	c.1399C>T	c.(1399-1401)Cct>Tct	p.P467S	MIA2_ENST00000280082.3_Missense_Mutation_p.P467S|MIA2_ENST00000556784.1_Missense_Mutation_p.P466S																							TTTTGACAACCCTTGGAACTT	0.323000													40	83					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724463	138724463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138724463G>A	ENST00000383163.2	-	1	647	c.648C>T	c.(646-648)ttC>ttT	p.F216F		NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	216	Pro-rich.									endometrium(3)|kidney(1)|lung(7)	11						ATTCCGGGTCGAAGAAGGGGC	0.662000													5	10					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43680132	43680132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43680132C>T	ENST00000404580.1	-	3	687	c.599G>A	c.(598-600)aGg>aAg	p.R200K	PSG5_ENST00000599812.1_Missense_Mutation_p.R293K|PSG5_ENST00000407356.1_Missense_Mutation_p.R200K|PSG5_ENST00000342951.6_Missense_Mutation_p.R200K|PSG5_ENST00000366175.3_Missense_Mutation_p.R200K|PSG5_ENST00000407568.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	200	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				AATGAGGATCCTGTTTTCAAT	0.507000													79	197					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42341730	42341730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42341730C>T	ENST00000217026.4	+	12	1935	c.1808C>T	c.(1807-1809)cCc>cTc	p.P603L	MYBL2_ENST00000396863.4_Missense_Mutation_p.P579L	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	603						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TCCACACTGCCCAAGTCTCTA	0.527000													11	16					0	0	1	0	0
OPRD1	4985	broad.mit.edu	37	1	29189342	29189342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:29189342C>T	ENST00000234961.2	+	3	908	c.666C>T	c.(664-666)ttC>ttT	p.F222F		NM_000911.3	NP_000902.3	P41143	OPRD_HUMAN	opioid receptor, delta 1	222					immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	TCTTCGCCTTCGTGGTGCCCA	0.647000													21	39					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135705	55135705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55135705G>A	ENST00000314706.3	+	1	346	c.346G>A	c.(346-348)Gag>Aag	p.E116K		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						CTTGCTCTCTGAGAAAAAGAC	0.403000													84	171					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400463	40400463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:40400463G>A	ENST00000338305.6	-	2	932	c.390C>T	c.(388-390)atC>atT	p.I130I		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	130						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGTTGTTCACGATAAGGTGCT	0.592000													12	44					0	0	1	0	0
PSMD9	5715	broad.mit.edu	37	12	122353804	122353804	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122353804C>T	ENST00000544724.1	+	3	2720	c.331C>T	c.(331-333)Cag>Tag	p.Q111*	RP11-87C12.2_ENST00000542602.1_Nonsense_Mutation_p.Q95*|PSMD9_ENST00000261817.2_Nonsense_Mutation_p.Q199*|PSMD9_ENST00000541212.1_Nonsense_Mutation_p.Q200*|RP11-87C12.2_ENST00000544911.1_3'UTR			O00233	PSMD9_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	200	PDZ.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of insulin secretion|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of insulin secretion|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	nucleus|proteasome regulatory particle	bHLH transcription factor binding|transcription coactivator activity			endometrium(1)|large_intestine(1)|lung(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000117)|Epithelial(86;0.000415)|BRCA - Breast invasive adenocarcinoma(302;0.231)		GGAAAAACACCAGCTTAGACT	0.468000													4	27					0	0	1	0	0
TM4SF20	79853	broad.mit.edu	37	2	228243815	228243815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228243815C>T	ENST00000304568.3	-	1	207	c.170G>A	c.(169-171)gGa>gAa	p.G57E		NM_024795.3	NP_079071.2	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	57						integral to membrane|plasma membrane		p.G57A(1)		breast(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(2)	10		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		CAGACCTGCTCCTATAATTCC	0.418000													26	82					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58118625	58118625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58118625C>T	ENST00000357272.4	+	26	4646	c.4481C>T	c.(4480-4482)tCa>tTa	p.S1494L	FLNB_ENST00000493452.1_Missense_Mutation_p.S1325L|FLNB_ENST00000490882.1_Missense_Mutation_p.S1525L|FLNB_ENST00000429972.2_Missense_Mutation_p.S1494L|FLNB_ENST00000419752.2_Missense_Mutation_p.S1325L|FLNB_ENST00000348383.5_Missense_Mutation_p.S1494L|FLNB_ENST00000295956.4_Missense_Mutation_p.S1494L|FLNB_ENST00000358537.3_Missense_Mutation_p.S1494L			O75369	FLNB_HUMAN	filamin B, beta	1494	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TACATGGTCTCAGTTAAATAT	0.512000													12	22					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868352	97868352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97868352G>A	ENST00000437310.1	+	1	183	c.123G>A	c.(121-123)ggG>ggA	p.G41G		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CCATCATGGGGAATCTTGGTC	0.403000													101	281					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783434	54783434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54783434G>A	ENST00000391748.1	-	5	551	c.424C>T	c.(424-426)Ctc>Ttc	p.L142F	LILRB2_ENST00000391746.1_Missense_Mutation_p.L142F|LILRB2_ENST00000314446.5_Missense_Mutation_p.L142F|LILRB2_ENST00000434421.1_Missense_Mutation_p.L26F|LILRB2_ENST00000391749.4_Missense_Mutation_p.L142F	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	142	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity	p.L142V(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACACTGGAGGGTCACCCTT	0.582000													39	107					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29587275	29587275	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:29587275A>T	ENST00000373779.3	+	7	1133	c.1004A>T	c.(1003-1005)cAc>cTc	p.H335L	PTPRU_ENST00000428026.2_Missense_Mutation_p.H335L|PTPRU_ENST00000460170.2_Missense_Mutation_p.H335L|PTPRU_ENST00000323874.8_Missense_Mutation_p.H335L|PTPRU_ENST00000345512.3_Missense_Mutation_p.H335L|PTPRU_ENST00000356870.3_Missense_Mutation_p.H335L	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	335	Fibronectin type-III 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GCTGAGGTGCACGCCGTCAGC	0.642000													24	44					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50235567	50235567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50235567C>T	ENST00000338821.5	-	20	2395	c.2131G>A	c.(2131-2133)Gag>Aag	p.E711K	ATP9A_ENST00000311637.5_Missense_Mutation_p.E575K|ATP9A_ENST00000402822.1_Missense_Mutation_p.E590K	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	711					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						AGGTGAGCCTCCCCGCGGTTG	0.592000													13	36					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74015056	74015056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74015056C>T	ENST00000301607.3	-	11	1476	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	EVPL_ENST00000586740.1_Missense_Mutation_p.R408Q	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	408	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GGGGTTTCTTCGCTGTGGCAG	0.682000													4	13					0	0	1	0	0
TRAV25	28658	broad.mit.edu	37	14	22580921	22580921	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22580921G>A	ENST00000390454.2	+	0	340																											AAGCAAAAAAGAACAGCTCCC	0.483000													12	20					0	0	1	0	0
CYP2S1	29785	broad.mit.edu	37	19	41704373	41704373	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41704373C>T	ENST00000310054.4	+	4	716	c.500C>T	c.(499-501)cCa>cTa	p.P167L	CYP2S1_ENST00000542619.1_Intron	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	167					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						CCAGGACGCCCATTCGATCCC	0.632000													59	135					0	0	1	0	0
SLC38A9	153129	broad.mit.edu	37	5	54929585	54929585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54929585G>A	ENST00000396865.2	-	14	2018	c.1427C>T	c.(1426-1428)cCt>cTt	p.P476L	SLC38A9_ENST00000416547.2_Missense_Mutation_p.P352L|SLC38A9_ENST00000512595.1_Missense_Mutation_p.P413L|SLC38A9_ENST00000539768.1_3'UTR|SLC38A9_ENST00000318672.3_Missense_Mutation_p.P476L|SLC38A9_ENST00000515629.1_Missense_Mutation_p.P413L	NM_173514.3	NP_775785.2	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	476					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				CCCTTACCTAGGATAAATGTC	0.458000													15	33					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50906815	50906815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50906815C>T	ENST00000440232.2	+	10	1256	c.1203C>T	c.(1201-1203)ttC>ttT	p.F401F	POLD1_ENST00000599857.1_Silent_p.F401F|POLD1_ENST00000595904.1_Silent_p.F401F	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	401					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding	p.F401F(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		TCCAGAACTTCGACCTTCCGT	0.627000								DNA polymerases (catalytic subunits)					61	135					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584900	1584900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1584900G>A	ENST00000381297.4	-	2	762	c.552C>T	c.(550-552)ctC>ctT	p.L184L		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	184						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCACGCTGGGGAGCATCGTCC	0.627000			T	CRLF2	"""B-ALL, Downs associated ALL"""								13	48					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674333	4674333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4674333G>A	ENST00000396952.5	+	2	1227	c.577G>A	c.(577-579)Gat>Aat	p.D193N	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D192Y(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTGGCCTGTGATGATATCCG	0.498000													73	125					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62288674	62288674	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62288674G>A	ENST00000378024.4	-	5	13489	c.13215C>T	c.(13213-13215)gtC>gtT	p.V4405V	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4405					nervous system development	nucleus	protein binding	p.V4405V(1)		NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGGGCAGAGAGACATCCACAT	0.468000													95	225					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24813411	24813411	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24813411G>A	ENST00000376451.2	+	8	1925	c.1665G>A	c.(1663-1665)gcG>gcA	p.A555A	KIAA1217_ENST00000307544.6_Silent_p.A555A|KIAA1217_ENST00000376452.3_Silent_p.A837A|KIAA1217_ENST00000458595.1_Silent_p.A837A|KIAA1217_ENST00000376462.1_Silent_p.A792A|KIAA1217_ENST00000430453.2_Intron|KIAA1217_ENST00000376454.3_Silent_p.A872A|KIAA1217_ENST00000396445.1_Silent_p.A555A|KIAA1217_ENST00000396446.1_Silent_p.A555A			Q5T5P2	SKT_HUMAN	KIAA1217	872					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTGGCGATGCGAAGTCGGAAG	0.642000													18	48					0	0	1	0	0
ZNF230	7773	broad.mit.edu	37	19	44514663	44514663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44514663C>T	ENST00000429154.2	+	5	700	c.472C>T	c.(472-474)Cct>Tct	p.P158S		NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	158	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				CTTTGATCCTCCTCAGCAGTT	0.438000													59	133					0	0	1	0	0
SH3GL1	6455	broad.mit.edu	37	19	4365544	4365544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4365544G>A	ENST00000269886.3	-	4	444	c.266C>T	c.(265-267)tCg>tTg	p.S89L	SH3GL1_ENST00000598564.1_Intron|SH3GL1_ENST00000417295.2_Intron	NM_003025.3	NP_003016.1	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	89	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			NS(1)|endometrium(2)|kidney(16)|large_intestine(3)|lung(2)|ovary(2)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		AAGCCCCTCCGACTGCGGGTA	0.652000			T	MLL	AL								37	99					0	0	1	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27788253	27788253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27788253C>T	ENST00000396319.2	+	2	198	c.110C>T	c.(109-111)aCc>aTc	p.T37I	TAX1BP1_ENST00000433216.2_5'UTR|TAX1BP1_ENST00000265393.6_Missense_Mutation_p.T37I|TAX1BP1_ENST00000409980.1_Missense_Mutation_p.T37I|TAX1BP1_ENST00000543117.1_Missense_Mutation_p.T37I	NM_006024.6	NP_006015.4	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I) binding protein 1	37					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(8)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31			GBM - Glioblastoma multiforme(3;0.0823)			TGTCATTACACCTTAACTCCA	0.368000													11	48					0	0	1	0	0
RAG2	5897	broad.mit.edu	37	11	36615272	36615272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:36615272C>T	ENST00000311485.3	-	2	608	c.447G>A	c.(445-447)ggG>ggA	p.G149G		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	149					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				CCATACTTTTCCCTCGGCTGT	0.453000									Familial Hemophagocytic Lymphohistiocytosis				45	79					0	0	1	0	0
IL13	3596	broad.mit.edu	37	5	131995954	131995954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131995954C>T	ENST00000304506.3	+	4	435	c.421C>T	c.(421-423)Cgc>Tgc	p.R141C	AC004041.2_ENST00000435042.1_RNA|IL13_ENST00000468334.1_3'UTR	NM_002188.2	NP_002179.2	P35225	IL13_HUMAN	interleukin 13	141					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			large_intestine(1)|lung(1)|ovary(1)|skin(3)	6		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAAACTTTTTCGCGAGGGACA	0.418000													18	60					0	0	1	0	0
LINC00639	283547	broad.mit.edu	37	14	39304962	39304962	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:39304962C>T	ENST00000553932.1	-	0	3600																											GAAGGCCTTTCGGCACAGCTT	0.552000													4	18					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117993048	117993048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117993048G>A	ENST00000425217.1	-	9	1411	c.1357C>T	c.(1357-1359)Cct>Tct	p.P453S	KSR2_ENST00000302438.5_Missense_Mutation_p.P179S|KSR2_ENST00000339824.5_Missense_Mutation_p.P482S|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	482					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCCGTAGAGGGTTGTTGATG	0.493000													11	21					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33549452	33549452	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33549452C>T	ENST00000504830.1	-	21	4497	c.4162G>A	c.(4162-4164)Gag>Aag	p.E1388K	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.E1303K	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1388	TSP type-1 6.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CACTGAATCTCGCGTATCTTG	0.562000										HNSCC(64;0.19)			19	119					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125875776	125875776	+	Missense_Mutation	SNP	G	G	A	rs145492265		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:125875776G>A	ENST00000392693.3	-	9	1856	c.1729C>T	c.(1729-1731)Cct>Tct	p.P577S	CDON_ENST00000263577.7_Missense_Mutation_p.P577S	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	577	Fibronectin type-III 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding	p.P577S(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		GGGGCATCAGGAACAGAGATG	0.562000													33	76					0	0	1	0	0
SLC24A4	123041	broad.mit.edu	37	14	92915537	92915537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92915537C>T	ENST00000532405.1	+	10	1083	c.857C>T	c.(856-858)cCt>cTt	p.P286L	SLC24A4_ENST00000531433.1_Intron|SLC24A4_ENST00000298877.1_Missense_Mutation_p.P269L|SLC24A4_ENST00000393265.2_Missense_Mutation_p.P222L|SLC24A4_ENST00000351924.5_Intron			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	286						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		TATGATGACCCTTCCGTGCCA	0.502000													16	40					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230877	39230877	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39230877C>T	ENST00000340369.3	-	2	288	c.60G>A	c.(58-60)gaG>gaA	p.E20E	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Silent_p.E20E	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	20	Interaction with VASP.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGGCAGGTCCTCTGCAGTTG	0.617000													20	35					0	0	1	0	0
SLC17A1	6568	broad.mit.edu	37	6	25811878	25811878	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25811878A>G	ENST00000244527.4	-	9	1133	c.1018T>C	c.(1018-1020)Ttc>Ctc	p.F340L	SLC17A1_ENST00000468082.1_Missense_Mutation_p.F286L|SLC17A1_ENST00000427328.1_Missense_Mutation_p.F286L|SLC17A1_ENST00000476801.1_Missense_Mutation_p.F340L	NM_005074.3	NP_005065.2	Q14916	NPT1_HUMAN	solute carrier family 17 (organic anion transporter), member 1	340					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	36						GCTGCTGTGAAGAGTTTCCGG	0.458000													14	90					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19337746	19337746	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19337746C>T	ENST00000252575.5	+	7	1567	c.1524C>T	c.(1522-1524)gcC>gcT	p.A508A		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	508					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			AGGCCAGCGCCCAGCCCCCCA	0.652000													17	28					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10223741	10223741	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10223741C>T	ENST00000418404.3	-	24	3347	c.3184G>A	c.(3184-3186)Gat>Aat	p.D1062N	MYH13_ENST00000570743.1_Missense_Mutation_p.D1062N|MYH13_ENST00000252172.4_Missense_Mutation_p.D1062N|RP11-401O9.3_ENST00000577743.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1062					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						ATTTTCAGATCTCCTTCCAGC	0.423000													7	7					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56276946	56276946	+	Missense_Mutation	SNP	G	G	A	rs149447728		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56276946G>A	ENST00000225371.5	+	9	1438	c.1328G>A	c.(1327-1329)cGg>cAg	p.R443Q		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	443					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						GGCAAGGCCCGGGCCAGGAGA	0.597000													37	48					0	0	1	0	0
DTX3	196403	broad.mit.edu	37	12	58000277	58000277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58000277C>T	ENST00000551632.1	+	3	140	c.5C>T	c.(4-6)cCa>cTa	p.P2L	DTX3_ENST00000548804.1_5'UTR|DTX3_ENST00000548198.1_5'UTR|DTX3_ENST00000337737.3_5'UTR			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	0					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					GCCTGCATGCCAATTCTAAGC	0.502000													9	21					0	0	1	0	0
CHST2	9435	broad.mit.edu	37	3	142840893	142840893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142840893C>T	ENST00000309575.3	+	2	2619	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	412					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						GCCCTGCAGCCCCCTGACTGG	0.617000													28	49					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20990797	20990797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20990797C>T	ENST00000261383.3	-	50	7930	c.7931G>A	c.(7930-7932)cGa>cAa	p.R2644Q	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2644	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GTTGTGTCTTCGAAGTTTGTT	0.478000													32	67					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884482	228884482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228884482C>T	ENST00000392056.3	-	7	1134	c.1088G>A	c.(1087-1089)aGa>aAa	p.R363K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.R363K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	363						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TAGGTTGCTTCTCTGCTCTGC	0.438000													34	101					0	0	1	0	0
ARG2	384	broad.mit.edu	37	14	68117433	68117433	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:68117433G>C	ENST00000261783.3	+	8	1041	c.859_splice	c.e8-1	p.G287_splice	VTI1B_ENST00000554659.1_3'UTR	NM_001172.3	NP_001163.1	P78540	ARGI2_HUMAN	arginase 2	287					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|ovary(1)|prostate(1)	11				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	TTCTTCCAGGGTTGCTATCAG	0.488000													7	64					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66859118	66859118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:66859118G>A	ENST00000359742.4	-	8	1049	c.809C>T	c.(808-810)tCg>tTg	p.S270L	GRIP1_ENST00000286445.7_Missense_Mutation_p.S270L|GRIP1_ENST00000398016.3_Missense_Mutation_p.S270L			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	270	PDZ 3.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		ACAGCACATCGAGGTAGTTAG	0.463000													35	76					0	0	1	0	0
KRTAP24-1	643803	broad.mit.edu	37	21	31654819	31654819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31654819G>A	ENST00000340345.4	-	1	457	c.432C>T	c.(430-432)acC>acT	p.T144T		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	144						keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						CGTTGCGGAGGGTTTGGCAGG	0.498000													36	122					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2718589	2718589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:2718589G>A	ENST00000382082.3	+	1	1088	c.850G>A	c.(850-852)Gag>Aag	p.E284K		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	284						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		CACCGTGGAGGAGATGCAGCA	0.672000													5	16					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95274346	95274346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95274346C>T	ENST00000344604.5	-	5	1266	c.1117G>A	c.(1117-1119)Gat>Aat	p.D373N	CENPP_ENST00000375587.3_Intron|ECM2_ENST00000444490.2_Missense_Mutation_p.D351N	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	373					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						TTACTCAGATCAAGCCTTTCC	0.393000													25	59					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40078519	40078519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40078519G>A	ENST00000336649.4	+	38	5701	c.5701G>A	c.(5701-5703)Gag>Aag	p.E1901K	CACNA1I_ENST00000407673.1_Missense_Mutation_p.E1860K|CACNA1I_ENST00000404898.1_Missense_Mutation_p.E1860K|CACNA1I_ENST00000402142.3_Missense_Mutation_p.E1895K|CACNA1I_ENST00000401624.1_Missense_Mutation_p.E1895K|CACNA1I_ENST00000400164.3_Missense_Mutation_p.E1860K			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1895					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGACCCACCTGAGCCCATGCG	0.607000													47	96					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87229949	87229949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87229949G>A	ENST00000297524.3	-	3	1032	c.929C>T	c.(928-930)tCa>tTa	p.S310L	SLC7A13_ENST00000419776.2_Missense_Mutation_p.S301L|SLC7A13_ENST00000520624.1_5'UTR	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	310						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						TGGTCTCGATGATTTAAATAT	0.383000													52	153					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24773215	24773215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24773215C>T	ENST00000221166.5	+	2	1960	c.1178C>T	c.(1177-1179)gCt>gTt	p.A393V	NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000433454.2_Missense_Mutation_p.A17V|NEFM_ENST00000437366.2_Missense_Mutation_p.A393V|NEFM_ENST00000518131.1_Missense_Mutation_p.A393V			P07197	NFM_HUMAN	neurofilament, medium polypeptide	393	Coil 2B.|Rod.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GTCAAGATGGCTCTGGATATA	0.547000													22	37					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222802183	222802183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:222802183C>T	ENST00000344922.5	+	4	1646	c.1621C>T	c.(1621-1623)Cac>Tac	p.H541Y	MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344441.6_Missense_Mutation_p.H541Y|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	541					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		AGGAATGCTCCACGAAGAAAA	0.413000													16	146					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15131471	15131471	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15131471G>A	ENST00000292574.3	+	3	956	c.874_splice	c.e3+1	p.A292_splice		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	292					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						CTATAACCCAGGTAGGAGTCC	0.602000													8	25					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373317	126373317	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126373317C>T	ENST00000394329.3	+	9	11159	c.11146C>T	c.(11146-11148)Cgt>Tgt	p.R3716C	FAT4_ENST00000335110.5_Missense_Mutation_p.R2014C	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3716					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R3716C(4)		NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CATCTTACTTCGTCTCGGCGT	0.468000													16	166					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7673916	7673916	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7673916C>T	ENST00000572933.1	+	26	5600	c.4140C>T	c.(4138-4140)ctC>ctT	p.L1380L	DNAH2_ENST00000389173.2_Silent_p.L1380L			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1380	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGACTCAGCTCGACATAGTAC	0.542000													29	47					0	0	1	0	0
SOHLH1	402381	broad.mit.edu	37	9	138586200	138586200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138586200G>A	ENST00000298466.5	-	7	1039	c.979C>T	c.(979-981)Ccc>Tcc	p.P327S	SOHLH1_ENST00000425225.1_Intron	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1	327					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		GCTTACGCGGGGGGACCAGCC	0.647000													12	34					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130897787	130897787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130897787C>T	ENST00000392984.3	-	4	1890	c.1147G>A	c.(1147-1149)Gag>Aag	p.E383K	CCDC74B_ENST00000310463.6_Missense_Mutation_p.E281K|CCDC74B_ENST00000409943.3_Missense_Mutation_p.E215K			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	281										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					TTCCACAGCTCGCGGATGAGC	0.682000													19	67					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68968189	68968189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68968189C>T	ENST00000288368.4	+	10	1495	c.1218C>T	c.(1216-1218)ttC>ttT	p.F406F	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	406	DEP 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TGACTACGTTCCCTAAATGCT	0.393000													29	86					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48699373	48699373	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:48699373G>A	ENST00000236495.5	+	10	1205	c.1155G>A	c.(1153-1155)ggG>ggA	p.G385G	SLC5A9_ENST00000438567.2_Silent_p.G360G|SLC5A9_ENST00000533824.1_Silent_p.G381G|SLC5A9_ENST00000420136.2_3'UTR	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	360						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						GAATCTGTGGGGCCCGAGTGG	0.562000													6	31					0	0	1	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435978	5435978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5435978G>A	ENST00000380419.3	-	4	880	c.843C>T	c.(841-843)ccC>ccT	p.P281P	TUBAL3_ENST00000479328.1_Silent_p.P241P	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	281					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						CAGAGACGATGGGGGCGAAGG	0.517000													39	107					0	0	1	0	0
FGL1	2267	broad.mit.edu	37	8	17726125	17726125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17726125C>T	ENST00000398056.2	-	9	1526	c.711G>A	c.(709-711)tgG>tgA	p.W237*	FGL1_ENST00000398054.1_Nonsense_Mutation_p.W237*|FGL1_ENST00000522444.1_Nonsense_Mutation_p.W237*|FGL1_ENST00000518650.1_Nonsense_Mutation_p.W237*|FGL1_ENST00000381840.2_Nonsense_Mutation_p.W237*|FGL1_ENST00000427924.1_Nonsense_Mutation_p.W237*|FGL1_ENST00000381841.2_Nonsense_Mutation_p.W237*			Q08830	FGL1_HUMAN	fibrinogen-like 1	237	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)	13				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		GATCTCTGTCCCACGTGCTGA	0.463000													58	131					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9489635	9489635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9489635C>T	ENST00000402466.1	+	16	2522	c.1754C>T	c.(1753-1755)tCa>tTa	p.S585L	SETD5_ENST00000488236.1_3'UTR|SETD5_ENST00000406341.1_Missense_Mutation_p.S683L|SETD5_ENST00000402198.1_Missense_Mutation_p.S683L|SETD5_ENST00000407969.1_Missense_Mutation_p.S702L|SETD5_ENST00000302463.6_Missense_Mutation_p.S585L			Q9C0A6	SETD5_HUMAN	SET domain containing 5	683										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		ACTGTGGTGTCAATTACTGGA	0.453000													10	20					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238726810	238726810	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238726810C>T	ENST00000316997.4	+	3	1383	c.1251C>T	c.(1249-1251)atC>atT	p.I417I	RBM44_ENST00000444524.2_Intron|RBM44_ENST00000409864.1_Silent_p.I417I	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	416							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		TACCAAAGATCGCAGTCAGAG	0.373000													17	38					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13183510	13183510	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:13183510G>A	ENST00000319217.7	-	19	2803	c.2556C>T	c.(2554-2556)atC>atT	p.I852I	MPDZ_ENST00000381015.4_Silent_p.I852I|MPDZ_ENST00000447879.1_Silent_p.I852I|MPDZ_ENST00000381022.2_Silent_p.I852I|MPDZ_ENST00000541718.1_Silent_p.I852I|MPDZ_ENST00000536827.1_Silent_p.I852I|MPDZ_ENST00000546205.1_Silent_p.I852I	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	852					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		GAGTAGAGTAGATGCTGTCAT	0.403000													5	27					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33590564	33590564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33590564G>A	ENST00000404816.2	+	31	5058	c.4705G>A	c.(4705-4707)Gat>Aat	p.D1569N	LTBP1_ENST00000404525.1_Missense_Mutation_p.D1190N|LTBP1_ENST00000402934.1_Missense_Mutation_p.D1188N|LTBP1_ENST00000272273.5_Missense_Mutation_p.D467N|LTBP1_ENST00000390003.4_Missense_Mutation_p.D1244N|LTBP1_ENST00000418533.2_Missense_Mutation_p.D1201N|LTBP1_ENST00000407925.1_Missense_Mutation_p.D1243N|LTBP1_ENST00000354476.3_Missense_Mutation_p.D1570N			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1569	TB 4.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCCCCTGAAGGATTCAGGTGA	0.542000													24	36					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128324336	128324336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128324336G>A	ENST00000262462.4	+	3	1739	c.729G>A	c.(727-729)agG>agA	p.R243R	SLC27A6_ENST00000506176.1_Silent_p.R243R|SLC27A6_ENST00000395266.1_Silent_p.R243R			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	243					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGGTTTTAAGGGGTTCTGCTG	0.393000													53	126					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177249597	177249597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177249597G>A	ENST00000361539.4	+	8	1597	c.1285G>A	c.(1285-1287)Gaa>Aaa	p.E429K	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		429						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CTACTGTGGGGAAAGCACCTT	0.542000													32	81					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177226448	177226448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177226448C>T	ENST00000361539.4	+	4	909	c.597C>T	c.(595-597)gcC>gcT	p.A199A	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		199						extracellular region		p.A199A(1)		breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AGCTGGCCGCCTCCTACTTCA	0.582000													12	38					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374046	27374046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27374046C>T	ENST00000395762.2	+	11	1632	c.1373C>T	c.(1372-1374)cCc>cTc	p.P458L	IL4R_ENST00000380922.3_Missense_Mutation_p.P443L|IL4R_ENST00000543915.2_Missense_Mutation_p.P458L|IL4R_ENST00000170630.2_Missense_Mutation_p.P458L	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	458	Required for IRS1 activation and IL4- induced cell growth.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GAGGCACCTCCCTGGGGCAAG	0.622000													17	69					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43214476	43214476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43214476C>T	ENST00000259750.4	+	2	161	c.78C>T	c.(76-78)gcC>gcT	p.A26A		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	26						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TCCTGCCGGCCAACTACGTGG	0.642000													13	34					0	0	1	0	0
TEKT1	83659	broad.mit.edu	37	17	6716194	6716194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6716194C>T	ENST00000338694.2	-	6	937	c.808G>A	c.(808-810)Gat>Aat	p.D270N	TEKT1_ENST00000535086.1_Missense_Mutation_p.D124N	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	270					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				TCCTTTGTATCCTTCAGCCCA	0.537000													49	75					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26165032	26165032	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26165032G>A	ENST00000335473.7	+	4	1399	c.1149G>A	c.(1147-1149)ggG>ggA	p.G383G	MYO18B_ENST00000536101.1_Silent_p.G383G|MYO18B_ENST00000407587.2_Silent_p.G383G	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	383						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCACGACTGGGAAGGCAGGTG	0.582000													11	20					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167863177	167863177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167863177G>A	ENST00000367848.1	-	8	963	c.466C>T	c.(466-468)Ctc>Ttc	p.L156F	ADCY10_ENST00000367851.4_Missense_Mutation_p.L248F|ADCY10_ENST00000545172.1_Missense_Mutation_p.L95F			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	248	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AGCCTCAGGAGGTCTAAGAAG	0.502000													9	28					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60635212	60635212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60635212C>T	ENST00000278853.5	+	1	178	c.178C>T	c.(178-180)Ctc>Ttc	p.L60F		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	60					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix		p.L60F(1)		breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						AGGCCAGACTCTCCGCTTCAA	0.677000													14	19					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8111504	8111504	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:8111504G>A	ENST00000379328.3	+	5	1561	c.993G>A	c.(991-993)agG>agA	p.R331R	GATA3_ENST00000346208.3_Silent_p.R330R|GATA3_ENST00000461472.1_3'UTR	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	330					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						TCTGGAGGAGGAATGCCAATG	0.557000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						41	80					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135384291	135384291	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:135384291C>T	ENST00000354042.4	-	8	1406	c.717G>A	c.(715-717)aaG>aaA	p.K239K		NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4	239						integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						GGACTTGTGGCTTTTCCTAAC	0.542000													17	47					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51839476	51839476	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51839476G>A	ENST00000251076.5	-	7	984	c.697C>T	c.(697-699)Cga>Tga	p.R233*	DMXL2_ENST00000543779.2_Nonsense_Mutation_p.R233*|DMXL2_ENST00000449909.3_Nonsense_Mutation_p.R233*	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	233						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		GTCACAGCTCGGGGATGTGCC	0.383000													28	82					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605356	140605356	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140605356G>A	ENST00000239449.4	+	1	2279	c.2279G>A	c.(2278-2280)gGg>gAg	p.G760E	PCDHB14_ENST00000515856.2_Missense_Mutation_p.G607E	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		760					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGTTCCGGGACAAATGAG	0.512000													43	122					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221230	161221230	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161221230G>A	ENST00000327928.4	+	4	934	c.934G>A	c.(934-936)Gac>Aac	p.D312N		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	312	Collagen-like 3.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						GCCGAAGGGTGACATTGGCAA	0.582000													8	23					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45821719	45821719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45821719C>T	ENST00000397928.1	+	16	2922	c.2477C>T	c.(2476-2478)tCc>tTc	p.S826F	TRPM2_ENST00000300481.9_Missense_Mutation_p.S806F|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.S826F|TRPM2_ENST00000397932.2_Missense_Mutation_p.S826F	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	826						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCTGTGCCCTCCTGGTGCGAG	0.632000													113	255					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166012313	166012313	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166012313G>A	ENST00000360093.3	-	10	1623	c.1132C>T	c.(1132-1134)Cga>Tga	p.R378*	SCN3A_ENST00000283254.7_Nonsense_Mutation_p.R378*|SCN3A_ENST00000409101.3_Nonsense_Mutation_p.R378*	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	378						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R378*(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GTCATGAGTCGAAATAGAGAC	0.413000													27	76					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31736914	31736914	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31736914G>A	ENST00000375686.3	-	10	1621	c.1384C>T	c.(1384-1386)Cct>Tct	p.P462S	VWA7_ENST00000447450.1_Missense_Mutation_p.P462S|VWA7_ENST00000467576.1_5'UTR|VWA7_ENST00000375688.4_Missense_Mutation_p.P462S	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	462						extracellular region											AAACGCAGAGGGGACAAGATC	0.537000													16	67					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142723368	142723368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142723368G>A	ENST00000350513.2	-	1	914	c.852C>T	c.(850-852)ttC>ttT	p.F284F		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					GAGTAAAGATGAAAGGATTCA	0.438000													33	85					0	0	1	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37964343	37964343	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37964343C>T	ENST00000249014.4	+	3	1112	c.692C>T	c.(691-693)cCc>cTc	p.P231L		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	231	8 X 7 AA tandem repeats of [PT]-[AT]-A- [ENT]-[PT]-[PTS]-[AG].				positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					GCTGCAAACCCCCCAGCCCCT	0.667000													11	33					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99634720	99634720	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99634720G>A	ENST00000393483.3	-	20	2859	c.2015C>T	c.(2014-2016)tCa>tTa	p.S672L	TSGA10_ENST00000355053.4_Missense_Mutation_p.S672L|TSGA10_ENST00000410001.1_Missense_Mutation_p.S672L|TSGA10_ENST00000539964.1_Missense_Mutation_p.S672L	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	672	Interaction with HIF1A (By similarity).				spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						ACGTTCTGGTGAATGACATTT	0.418000													18	63					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13922279	13922279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13922279G>A	ENST00000265104.4	-	5	701	c.597C>T	c.(595-597)ttC>ttT	p.F199F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	199	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGGAGCTCAAGAACTCCTGGC	0.542000									Kartagener syndrome				17	34					0	0	1	0	0
HEPN1	641654	broad.mit.edu	37	11	124789726	124789726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124789726G>A	ENST00000408930.5	+	1	581	c.80G>A	c.(79-81)gGa>gAa	p.G27E	HEPACAM_ENST00000298251.4_3'UTR	NM_001037558.2	NP_001032647.2	Q6WQI6	HEPN1_HUMAN	hepatocellular carcinoma, down-regulated 1	27						cytoplasm				large_intestine(1)|lung(1)|stomach(1)	3	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		GGGATGCAAGGACCCTTGGAG	0.507000													5	68					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15826454	15826454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15826454C>T	ENST00000338282.6	-	27	3724	c.3618G>A	c.(3616-3618)gaG>gaA	p.E1206E	MYH11_ENST00000576790.1_Silent_p.E1206E|MYH11_ENST00000396324.3_Silent_p.E1213E|MYH11_ENST00000452625.2_Silent_p.E1213E|MYH11_ENST00000300036.5_Silent_p.E1206E|AF001548.5_ENST00000574212.1_RNA	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1206					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTGTGAGCTCCTCCACCGCCT	0.527000			T	CBFB	AML								39	151					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743056	26743056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26743056C>T	ENST00000396005.3	-	1	515	c.206G>A	c.(205-207)gGg>gAg	p.G69E	SLC5A12_ENST00000280467.6_Missense_Mutation_p.G69E	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	69					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						AGAAGGGGTCCCCAGGACCGT	0.527000													20	55					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24388527	24388527	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24388527C>T	ENST00000330966.7	-	33	4014	c.3852G>A	c.(3850-3852)ctG>ctA	p.L1284L	MYOM3_ENST00000338909.5_Silent_p.L174L|MYOM3_ENST00000374434.3_Silent_p.L1281L|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1281										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CTTTGGGGTCCAGGATGTGAA	0.522000													57	188					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41686444	41686444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41686444G>A	ENST00000313860.7	+	22	2778	c.2724G>A	c.(2722-2724)ggG>ggA	p.G908G	LIMCH1_ENST00000513024.1_Silent_p.G761G|LIMCH1_ENST00000396595.3_Silent_p.G753G|LIMCH1_ENST00000381753.4_Silent_p.G741G|LIMCH1_ENST00000512946.1_Silent_p.G908G|LIMCH1_ENST00000514096.1_Silent_p.G748G|LIMCH1_ENST00000509277.1_Silent_p.G741G|LIMCH1_ENST00000512820.1_Silent_p.G920G|LIMCH1_ENST00000508501.1_Silent_p.G907G|LIMCH1_ENST00000503057.1_Silent_p.G1292G|LIMCH1_ENST00000512632.1_Silent_p.G831G|LIMCH1_ENST00000511496.1_Silent_p.G748G	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	908					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						CTCATTCTGGGAACCCTGTAT	0.473000													20	75					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	91034604	91034604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91034604C>T	ENST00000268182.5	+	34	4412	c.4288C>T	c.(4288-4290)Cgt>Tgt	p.R1430C	IQGAP1_ENST00000560738.1_Missense_Mutation_p.R858C	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1430	C2.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			ACGTGCTATCCGTGATGCCAA	0.408000													13	83					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37262241	37262241	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37262241C>T	ENST00000310758.4	-	10	1406	c.759G>A	c.(757-759)aaG>aaA	p.K253K	ELMO1_ENST00000448602.1_Silent_p.K253K|ELMO1_ENST00000442504.1_Silent_p.K253K	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	253					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						CATCAGGAGCCTTCAGGAAAA	0.418000													30	82					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23927219	23927219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23927219G>A	ENST00000402377.3	-	4	1274	c.1133C>T	c.(1132-1134)tCc>tTc	p.S378F	ZNF681_ENST00000395385.3_Missense_Mutation_p.S309F	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AAGGTGTGAGGACTGCCTAAA	0.408000													35	92					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842311	5842311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5842311C>T	ENST00000317037.2	+	1	768	c.746C>T	c.(745-747)tCc>tTc	p.S249F	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	249			S -> A (in dbSNP:rs8181529).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACATGTGTTCCATTGTGATC	0.428000													11	117					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178565851	178565851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:178565851C>T	ENST00000286063.5	-	14	2559	c.2242G>A	c.(2242-2244)Gag>Aag	p.E748K	PDE11A_ENST00000358450.4_Missense_Mutation_p.E498K|PDE11A_ENST00000409504.1_Missense_Mutation_p.E390K|PDE11A_ENST00000449286.2_Missense_Mutation_p.E390K|AC012499.1_ENST00000450227.1_RNA|AC012499.1_ENST00000412133.1_RNA|PDE11A_ENST00000389683.3_Missense_Mutation_p.E304K|PDE11A_ENST00000497003.1_5'UTR	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	748	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GCCTGTACCTCACTTTGAAGG	0.502000									Primary Pigmented Nodular Adrenocortical Disease, Familial				7	27					0	0	1	0	0
KHSRP	8570	broad.mit.edu	37	19	6421694	6421694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6421694G>A	ENST00000398148.3	-	3	444	c.352C>T	c.(352-354)Ccg>Tcg	p.P118S		NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	118	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						TTGCTCTCCGGTTGATCTGGG	0.582000													32	109					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	4107730	4107730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4107730C>T	ENST00000300737.4	+	11	2067	c.1498C>T	c.(1498-1500)Cgg>Tgg	p.R500W	STIM1_ENST00000533977.1_Missense_Mutation_p.R327W|STIM1_ENST00000527651.1_Missense_Mutation_p.R500W	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	500					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		GAGCAGTGTTCGGCAGCGCCT	0.592000													11	42					0	0	1	0	0
UPB1	51733	broad.mit.edu	37	22	24896103	24896103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24896103G>A	ENST00000326010.5	+	2	477	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	UPB1_ENST00000382760.2_Missense_Mutation_p.E45K|UPB1_ENST00000413389.2_Intron	NM_016327.2	NP_057411.1	Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	45					pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					GGAAGCTTTCGAAGCTGCCTC	0.522000													41	86					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57189311	57189311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57189311C>T	ENST00000343433.6	-	17	2004	c.1924G>A	c.(1924-1926)Gaa>Aaa	p.E642K		NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	642										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CTGTTCTTTTCTAAGTTTTGC	0.313000													14	38					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88761427	88761427	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88761427C>T	ENST00000444431.1	+	0	2557				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										CAATACAGCTCGTGTTCGACA	0.388000													68	133					0	0	1	0	0
ELOVL6	79071	broad.mit.edu	37	4	110972698	110972698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110972698G>A	ENST00000394607.3	-	5	757	c.594C>T	c.(592-594)atC>atT	p.I198I	ELOVL6_ENST00000302274.3_Silent_p.I198I			Q9H5J4	ELOV6_HUMAN	ELOVL fatty acid elongase 6	198					fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	8				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		GGGACAAGGTGATGAACATGG	0.517000													31	63					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46766894	46766894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46766894C>T	ENST00000230588.4	+	5	247	c.238C>T	c.(238-240)Cct>Tct	p.P80S		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	80	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			GTTCCCCATTCCTTACATCTT	0.438000													29	104					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27516588	27516588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27516588G>A	ENST00000301904.3	+	5	921	c.901G>A	c.(901-903)Gta>Ata	p.V301I	SCARA3_ENST00000337221.4_Missense_Mutation_p.V301I	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	301					response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		GCACGACCTGGTACTCCAGGT	0.562000													20	42					0	0	1	0	0
KLC2	64837	broad.mit.edu	37	11	66026257	66026257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66026257C>T	ENST00000417856.1	+	2	435	c.192C>T	c.(190-192)tcC>tcT	p.S64S	KLC2_ENST00000421552.1_Silent_p.S64S|KLC2_ENST00000394067.2_Silent_p.S64S|KLC2_ENST00000394066.2_Silent_p.S64S|KLC2_ENST00000316924.5_Silent_p.S64S|KLC2_ENST00000394078.1_Silent_p.S64S	NM_001134775.1	NP_001128247.1	Q9H0B6	KLC2_HUMAN	kinesin light chain 2	64					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						TGCGTCGCTCCCTGGAAGCCA	0.662000											OREG0021097	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	38					0	0	1	0	0
PMP2	5375	broad.mit.edu	37	8	82357107	82357107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:82357107G>A	ENST00000256103.2	-	2	327	c.191C>T	c.(190-192)tCc>tTc	p.S64F	PMP2_ENST00000519260.1_Intron|RP11-157I4.4_ENST00000524085.2_RNA	NM_002677.3	NP_002668.1	P02689	MYP2_HUMAN	peripheral myelin protein 2	64						cytoplasm	cholesterol binding|fatty acid binding|transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			Epithelial(68;0.186)			TAGCTTGAAGGAGATTTCTGT	0.388000													9	77					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41143071	41143071	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41143071C>T	ENST00000263413.3	-	18	2925	c.2661G>A	c.(2659-2661)caG>caA	p.Q887Q	C6_ENST00000337836.5_Silent_p.Q887Q	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	887	C5b-binding domain.|Complement control factor I module 2.|Kazal-like 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CCTTGAAGCACTGTGGGGGCA	0.433000													25	51					0	0	1	0	0
LRRC28	123355	broad.mit.edu	37	15	99828126	99828126	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:99828126G>A	ENST00000301981.3	+	5	595	c.355G>A	c.(355-357)Gct>Act	p.A119T	LRRC28_ENST00000422500.2_Missense_Mutation_p.A119T|LRRC28_ENST00000442993.2_Missense_Mutation_p.A119T|LRRC28_ENST00000447360.2_Missense_Mutation_p.A119T|LRRC28_ENST00000331450.5_Intron|LRRC28_ENST00000559399.1_3'UTR|LRRC28_ENST00000558879.1_Intron	NM_144598.2	NP_653199.2	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	119										endometrium(2)|large_intestine(3)|lung(6)|prostate(1)	12	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			TCTTCGATTAGCTAATAACCA	0.368000													26	160					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103324856	103324856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103324856G>A	ENST00000233969.2	+	12	2489	c.2347G>A	c.(2347-2349)Gaa>Aaa	p.E783K		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	783						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CAGTTTGACTGAAGGCATCCC	0.577000													36	119					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79428193	79428193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79428193C>T	ENST00000307745.7	+	30	6504	c.6504C>T	c.(6502-6504)ttC>ttT	p.F2168F	RP11-1055B8.8_ENST00000572590.1_RNA																							ACGCGCCCTTCGTCGGGGGGA	0.721000													4	12					0	0	1	0	0
APOL1	8542	broad.mit.edu	37	22	36661548	36661548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36661548G>A	ENST00000319136.4	+	7	981	c.714G>A	c.(712-714)ggG>ggA	p.G238G	APOL1_ENST00000397279.4_Silent_p.G222G|APOL1_ENST00000440669.2_3'UTR|APOL1_ENST00000422706.1_Silent_p.G222G|APOL1_ENST00000347595.7_Silent_p.G101G|APOL1_ENST00000426053.1_Silent_p.G204G|APOL1_ENST00000397278.3_Silent_p.G222G	NM_145343.2	NP_663318.1	O14791	APOL1_HUMAN	apolipoprotein L, 1	222					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	14						CTTTGACCGGGATTACCAGCA	0.557000													24	99					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70841800	70841800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70841800G>A	ENST00000393567.2	-	86	15199	c.15049C>T	c.(15049-15051)Ctc>Ttc	p.L5017F		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	5017										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ATTCCAAAGAGGGGGATGATA	0.537000													31	69					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872953	55872953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55872953C>T	ENST00000313503.1	+	1	435	c.435C>T	c.(433-435)atC>atT	p.I145I		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TCGCTCTCATCACTGGGCCTT	0.448000										HNSCC(53;0.14)			71	199					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62739693	62739693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62739693C>T	ENST00000371153.4	-	3	1461	c.1083G>A	c.(1081-1083)gaG>gaA	p.E361E	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	361										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GTGCCAGTTCCTCGGTTCTTC	0.567000													25	103					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90528592	90528592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90528592G>A	ENST00000282146.4	+	1	484	c.43G>A	c.(43-45)Gag>Aag	p.E15K		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	15						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CCACCTGAACGAGGACAACGC	0.756000													3	20					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169562877	169562877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169562877G>A	ENST00000263686.6	-	14	2410	c.2373C>T	c.(2371-2373)ctC>ctT	p.L791L	SELP_ENST00000458599.2_Silent_p.L607L|SELP_ENST00000367792.2_Silent_p.L607L|SELP_ENST00000367794.2_Silent_p.L729L|SELP_ENST00000367786.2_Silent_p.L729L|SELP_ENST00000367791.2_Silent_p.L605L|SELP_ENST00000367788.2_Silent_p.L729L|SELP_ENST00000367793.2_Silent_p.L729L	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	791					platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GCAAAGCCAGGAGCGTCCCAC	0.413000													9	58					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20651245	20651245	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20651245G>A	ENST00000428453.1	-	0	2392																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						AACTGTGGCAGAAGCACCTTG	0.502000													18	44					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92278668	92278668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92278668C>T	ENST00000435962.2	-	3	612	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K	TC2N_ENST00000556018.1_Missense_Mutation_p.E97K|TC2N_ENST00000360594.5_Missense_Mutation_p.E97K|TC2N_ENST00000340892.5_Missense_Mutation_p.E97K	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	97						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		TCAAGTTCTTCCAGATGTGAA	0.303000													13	36					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78853912	78853912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78853912G>A	ENST00000545128.1	+	23	3442	c.2904G>A	c.(2902-2904)gaG>gaA	p.E968E		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	664					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity	p.E968E(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						ACCAGGGAGAGTGTGGAGATA	0.527000													8	12					0	0	1	0	0
CUBNP3	100421634	broad.mit.edu	37	10	45644317	45644317	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45644317G>A	ENST00000427229.2	+	0	488																											TACCTAGAAAGTCACCAAGAC	0.338000													10	33					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82578909	82578909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82578909G>A	ENST00000423517.2	-	6	11332	c.10995C>T	c.(10993-10995)ccC>ccT	p.P3665P	PCLO_ENST00000437081.1_Silent_p.P385P|PCLO_ENST00000333891.8_Silent_p.P3665P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3596					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GACTTGCTGGGGGAACTTTAG	0.478000													27	284					0	0	1	0	0
PHYHD1	254295	broad.mit.edu	37	9	131702715	131702715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131702715C>T	ENST00000308941.5	+	9	923	c.503C>T	c.(502-504)tCg>tTg	p.S168L	PHYHD1_ENST00000372592.3_Silent_p.I175I|PHYHD1_ENST00000487504.1_3'UTR|PHYHD1_ENST00000421063.2_Silent_p.I154I|PHYHD1_ENST00000353176.5_Silent_p.I154I	NM_174933.3	NP_777593.2			phytanoyl-CoA dioxygenase domain containing 1											central_nervous_system(1)|endometrium(2)|large_intestine(3)|skin(1)|stomach(3)	10						GCGTGTGGATCGCAGTGGAGG	0.647000													23	77					0	0	1	0	0
IGHA1	3493	broad.mit.edu	37	14	106174793	106174793	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106174793C>T	ENST00000390547.2	-	0	209																											CCGGCAGGGTCAGCTGGCTGC	0.637000													13	54					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93629424	93629424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:93629424G>A	ENST00000375754.4	+	7	1006	c.858G>A	c.(856-858)gcG>gcA	p.A286A	SYK_ENST00000375746.1_Silent_p.A286A|SYK_ENST00000375751.4_Intron|SYK_ENST00000375747.1_Intron	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	286	Linker.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity	p.A286A(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						CTTGGTCAGCGGGTGGAATAA	0.443000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								25	76					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231264925	231264925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231264925G>A	ENST00000243810.6	+	15	1281	c.1281G>A	c.(1279-1281)gaG>gaA	p.E427E	SP140L_ENST00000415673.2_Silent_p.E427E|SP140L_ENST00000444636.1_Silent_p.E427E|SP140L_ENST00000396563.4_Silent_p.E392E			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	427						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						TCTTCCATGAGGACTGCCACA	0.512000													25	66					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50959019	50959019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50959019G>A	ENST00000374103.4	-	7	847	c.762C>T	c.(760-762)ttC>ttT	p.F254F	OGDHL_ENST00000419399.1_Silent_p.F197F|OGDHL_ENST00000432695.1_Silent_p.F45F	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	254					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TCCGGGCCAGGAAGTCTTCAA	0.567000													4	10					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57326923	57326923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57326923G>A	ENST00000326441.9	-	10	3250	c.2887C>T	c.(2887-2889)Cgc>Tgc	p.R963C	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.R839C|PEG3_ENST00000593695.1_Missense_Mutation_p.R837C|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.R963C	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	963					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R963C(2)		NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCTCGAGGGCGAAATGTTTGT	0.473000													60	163					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57395136	57395136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57395136G>A	ENST00000543257.1	-	13	2127	c.1561C>T	c.(1561-1563)Cct>Tct	p.P521S	C8B_ENST00000371237.4_Missense_Mutation_p.P573S|C8B_ENST00000535057.1_Missense_Mutation_p.P511S	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	573	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						CCATTTTGAGGAGGTGGATTG	0.483000													24	57					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110764073	110764073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:110764073G>A	ENST00000451085.1	+	4	2291	c.1245G>A	c.(1243-1245)atG>atA	p.M415I	IMMP2L_ENST00000489381.1_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.M415I|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000331762.3_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.M415I|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000447215.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	415	LRRCT.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TCAGGGACATGATGGAAATTT	0.443000													27	88					0	0	1	0	0
WFDC10B	280664	broad.mit.edu	37	20	44333618	44333618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44333618C>T	ENST00000335769.2	-	1	40	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	WFDC10B_ENST00000330523.5_5'UTR|WFDC13_ENST00000305479.2_Intron	NM_172131.2	NP_742143.1	Q8IUB3	WF10B_HUMAN	WAP four-disulfide core domain 10B	0						extracellular region	peptidase inhibitor activity			lung(2)|ovary(1)|stomach(1)	4		Myeloproliferative disorder(115;0.0122)				GCCCTCCTTTCACAAGACACC	0.488000													38	147					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337514	102337514	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:102337514G>A	ENST00000369138.1	+	11	2014		c.e11-1		GRIK2_ENST00000413795.1_Splice_Site|GRIK2_ENST00000369134.4_Splice_Site|GRIK2_ENST00000369137.3_Splice_Site|GRIK2_ENST00000318991.6_Splice_Site|GRIK2_ENST00000421544.1_Splice_Site	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2						glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TCTGTCTACAGAAAGCTGACC	0.318000													9	43					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73569208	73569208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73569208C>T	ENST00000392550.3	+	20	2691	c.2574C>T	c.(2572-2574)gaC>gaT	p.D858D	LLGL2_ENST00000167462.5_Silent_p.D858D|LLGL2_ENST00000577200.1_Silent_p.D858D	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	858					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			GAGCCGAGGACTACGGGGAGC	0.657000													17	42					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554157	140554157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140554157G>A	ENST00000231137.3	+	1	1915	c.1741G>A	c.(1741-1743)Gag>Aag	p.E581K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		581	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGCGGCCGAGCCGGGCTA	0.711000													37	119					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112172609	112172609	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112172609G>A	ENST00000412145.1	-	10	3560	c.1007C>T	c.(1006-1008)tCc>tTc	p.S336F	PTPN3_ENST00000446349.1_Missense_Mutation_p.S291F|PTPN3_ENST00000394827.3_5'UTR|PTPN3_ENST00000262539.3_Missense_Mutation_p.S313F|PTPN3_ENST00000374541.2_Missense_Mutation_p.S467F	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	467					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						AGGTGAGCAGGAGCCTGGAGC	0.537000													43	82					0	0	1	0	0
B3GALT1	8708	broad.mit.edu	37	2	168726366	168726366	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168726366C>T	ENST00000305861.1	+	2	1168	c.817C>T	c.(817-819)Cga>Tga	p.R273*	B3GALT1_ENST00000392690.2_Nonsense_Mutation_p.R273*|AC016723.4_ENST00000436982.2_RNA|AC016723.4_ENST00000430546.1_RNA	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	273					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						ACTGTGTCTTCGAAAGCTGGG	0.463000													26	64					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713060	46713060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46713060C>T	ENST00000318962.4	-	25	2782	c.2699G>A	c.(2698-2700)gGa>gAa	p.G900E	ALS2CL_ENST00000415953.1_Missense_Mutation_p.G900E|ALS2CL_ENST00000383742.3_Missense_Mutation_p.G247E	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	900	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GATCTCGGCTCCCAGGTGCTG	0.617000													14	65					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32065162	32065162	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32065162A>T	ENST00000375244.3	-	3	669	c.468T>A	c.(466-468)tgT>tgA	p.C156*	TNXB_ENST00000375247.2_Nonsense_Mutation_p.C156*|TNXB_ENST00000479795.1_Nonsense_Mutation_p.C156*			P22105	TENX_HUMAN	tenascin XB	156	EGF-like 1; incomplete.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCTCACAGGAACAGGTGCAGC	0.622000													12	39					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38855747	38855747	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38855747C>T	ENST00000409235.3	+	22	2718	c.2603C>T	c.(2602-2604)cCc>cTc	p.P868L	CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Missense_Mutation_p.P828L	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	868					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						CACCTGGGGCCCCATATGCAA	0.602000													29	69					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986446	51986446	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51986446C>T	ENST00000396477.4	+	4	870	c.849C>T	c.(847-849)ctC>ctT	p.L283L	CEACAM18_ENST00000451626.1_Silent_p.L344L	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	344						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGATGAACCTCTCGAGTCTTG	0.532000													37	112					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6096664	6096664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6096664G>A	ENST00000217289.4	-	3	967	c.179C>T	c.(178-180)gCt>gTt	p.A60V	FERMT1_ENST00000536936.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	60					cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						CCACCAAAGAGCAAAGTCTGA	0.493000													15	37					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89971131	89971131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89971131C>T	ENST00000405460.2	+	24	5278	c.5182C>T	c.(5182-5184)Cca>Tca	p.P1728S	GPR98_ENST00000450321.2_3'UTR	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1728					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGCAGCGTTCCACATATCAC	0.547000													11	19					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151304071	151304071	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151304071G>A	ENST00000370323.4	-	4	338	c.22C>T	c.(22-24)Cag>Tag	p.Q8*	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Nonsense_Mutation_p.Q8*	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	8										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ATGCAGCGCTGACGCTTTGGA	0.602000													41	39					0	0	1	0	0
OASL	8638	broad.mit.edu	37	12	121469298	121469298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121469298G>A	ENST00000257570.5	-	3	874	c.604C>T	c.(604-606)Cgg>Tgg	p.R202W	OASL_ENST00000339275.5_Missense_Mutation_p.R202W	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	202					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTAGTTGGCCGATGTTTCACG	0.587000													30	76					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97851872	97851872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97851872G>A	ENST00000354565.2	+	1	331	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						TGTAACCACGGAATGTTTTCT	0.408000													94	220					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6832117	6832117	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6832117C>T	ENST00000304076.2	+	15	1508	c.1414C>T	c.(1414-1416)Ctc>Ttc	p.L472F	VAV1_ENST00000596764.1_Missense_Mutation_p.L440F|VAV1_ENST00000539284.1_Missense_Mutation_p.L375F|VAV1_ENST00000599806.1_Missense_Mutation_p.L417F|VAV1_ENST00000602142.1_Missense_Mutation_p.L472F	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	472	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CCACATGTTCCTCCTGATCGA	0.567000													16	36					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99153491	99153491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:99153491G>A	ENST00000370992.4	-	4	591	c.480C>T	c.(478-480)tcC>tcT	p.S160S	RRP12_ENST00000414986.1_Intron|RRP12_ENST00000315563.6_Intron	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	160						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GGGACTCCGGGGACTCCACTG	0.527000													18	60					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32065163	32065163	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32065163C>T	ENST00000375244.3	-	3	668	c.467G>A	c.(466-468)tGt>tAt	p.C156Y	TNXB_ENST00000375247.2_Missense_Mutation_p.C156Y|TNXB_ENST00000479795.1_Missense_Mutation_p.C156Y			P22105	TENX_HUMAN	tenascin XB	156	EGF-like 1; incomplete.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CTCACAGGAACAGGTGCAGCG	0.617000													12	40					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61310809	61310809	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61310809C>T	ENST00000341074.5	-	2	118	c.3G>A	c.(1-3)atG>atA	p.M1I	SERPINB4_ENST00000356424.6_Start_Codon_SNP_p.M1I	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TGAGTGAATTCATGGTGAACT	0.373000													46	194					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100380631	100380631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100380631C>T	ENST00000262233.6	+	14	1749	c.1610C>T	c.(1609-1611)cCc>cTc	p.P537L	EML1_ENST00000327921.9_Missense_Mutation_p.P525L|EML1_ENST00000334192.4_Missense_Mutation_p.P556L	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	537						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GACTTCACACCCATTACTCAG	0.493000													27	72					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140746018	140746018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140746018C>T	ENST00000518069.1	+	1	2121	c.2121C>T	c.(2119-2121)ttC>ttT	p.F707F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGGCCTTCGTCATCGTGC	0.602000													28	293					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6439002	6439002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6439002G>A	ENST00000162749.2	-	9	1298	c.999C>T	c.(997-999)ccC>ccT	p.P333P	TNFRSF1A_ENST00000540022.1_Silent_p.P290P	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	333					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						GGTTGGGGATGGGGTCGGAGG	0.667000													5	6					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55905119	55905119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55905119G>A	ENST00000301529.1	-	1	75	c.76C>T	c.(76-78)Ccc>Tcc	p.P26S		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AGGAAGAGGGGAATCTGGAGC	0.493000													41	132					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128661	126128661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:126128661G>A	ENST00000299308.3	+	6	1470	c.1462G>A	c.(1462-1464)Gaa>Aaa	p.E488K	TMEM132B_ENST00000535886.1_5'UTR	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	488						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAATGGGAAGGAAATGAAGAG	0.483000													22	62					0	0	1	0	0
C14orf105	55195	broad.mit.edu	37	14	57947410	57947410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:57947410C>T	ENST00000216445.3	-	5	694	c.558G>A	c.(556-558)agG>agA	p.R186R	C14orf105_ENST00000422976.2_Silent_p.R185R|C14orf105_ENST00000534126.1_Silent_p.R185R	NM_018168.2	NP_060638.2	Q9NVL8	CN105_HUMAN	chromosome 14 open reading frame 105	186										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)	11						CTTTATGGTCCCTTGGACTTT	0.418000													50	121					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25994397	25994397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:25994397G>A	ENST00000435504.4	-	6	709	c.416C>T	c.(415-417)tCc>tTc	p.S139F	ASXL2_ENST00000336112.4_Missense_Mutation_p.S111F|ASXL2_ENST00000404843.1_5'UTR|ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	139	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACTGCGGGGAGGACGACGA	0.463000													12	41					0	0	1	0	0
ZNF112	7665	broad.mit.edu	37	19	44833552	44833552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44833552G>A	ENST00000354340.4	-	4	809	c.758C>T	c.(757-759)cCa>cTa	p.P253L	ZNF112_ENST00000536500.1_Missense_Mutation_p.P276L|ZNF112_ENST00000337401.4_Missense_Mutation_p.P259L	NM_013380.3	NP_037512.3			zinc finger protein 112																		CCCAGTACATGGATAGGGCTT	0.428000													36	106					0	0	1	0	0
BOD1L2	284257	broad.mit.edu	37	18	54814709	54814709	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:54814709C>T	ENST00000585477.1	+	1	417	c.166C>T	c.(166-168)Cgc>Tgc	p.R56C		NM_001257964.1	NP_001244893.1			biorientation of chromosomes in cell division 1-like 2																		TGACAGCTTCCGCCGGGACTG	0.592000													4	9					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17721594	17721594	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17721594G>A	ENST00000434762.2	+	0	1536							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	ACAAGAATGAGGGCAAAAAGG	0.512000													34	90					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769799	140769799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140769799C>T	ENST00000519479.1	+	1	2348	c.2348C>T	c.(2347-2349)tCt>tTt	p.S783F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGATTCATCTGGGGCCTTA	0.388000													36	237					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520981	131520981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131520981G>A	ENST00000423981.1	+	2	1446	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	AMER3_ENST00000321420.4_Missense_Mutation_p.E446K	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GTGCGTGTCTGAGAGTCTGTC	0.662000													21	48					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1092112	1092112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1092112G>A	ENST00000441003.2	+	30	3958	c.3931G>A	c.(3931-3933)Gag>Aag	p.E1311K	MUC2_ENST00000359061.5_Missense_Mutation_p.E1312K	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1311						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CTGGATCAATGAGGACCACCC	0.592000													10	17					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20525739	20525739	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20525739C>T	ENST00000504154.1	+	14	1629	c.1377C>T	c.(1375-1377)agC>agT	p.S459S	SLIT2_ENST00000273739.5_Silent_p.S463S|SLIT2_ENST00000503823.1_Silent_p.S459S|SLIT2_ENST00000503837.1_Silent_p.S463S	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	459	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GTTGCACCAGCCCCCGCCGCC	0.488000													47	197					0	0	1	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176768298	176768298	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:176768298G>A	ENST00000430069.1	-	6	787	c.528C>T	c.(526-528)gcC>gcT	p.A176A	TBL1XR1_ENST00000457928.2_Silent_p.A176A			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	176					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			CAGGGTTCCAGGCACAGATAA	0.363000													8	28					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179720208	179720208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179720208G>A	ENST00000420890.2	-	19	3043	c.2926C>T	c.(2926-2928)Cca>Tca	p.P976S	CCDC141_ENST00000295723.5_Missense_Mutation_p.P401S	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	401							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTATCACTTGGATAATTTAAG	0.294000													21	47					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46263977	46263977	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46263977C>T	ENST00000510861.1	-	9	1198	c.1025G>A	c.(1024-1026)tGg>tAg	p.W342*	GABRA2_ENST00000381620.4_Nonsense_Mutation_p.W342*|GABRA2_ENST00000507069.1_Nonsense_Mutation_p.W342*|GABRA2_ENST00000356504.1_Nonsense_Mutation_p.W342*|GABRA2_ENST00000514090.1_Nonsense_Mutation_p.W342*|GABRA2_ENST00000515082.1_Nonsense_Mutation_p.W342*|GABRA2_ENST00000540012.1_Nonsense_Mutation_p.W287*			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	342					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATCCCAAGCCCATCCTCTTTT	0.383000													33	111					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160141071	160141071	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160141071C>T	ENST00000368081.4	+	11	1993	c.1522C>T	c.(1522-1524)Cag>Tag	p.Q508*		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	508					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGACAGCTCCCAGACCCACGT	0.517000													42	117					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57732829	57732829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57732829G>A	ENST00000360716.3	+	4	492	c.271G>A	c.(271-273)Gag>Aag	p.E91K	CCDC135_ENST00000394337.4_Missense_Mutation_p.E91K|RP11-405F3.4_ENST00000563062.1_RNA|CCDC135_ENST00000336825.8_Missense_Mutation_p.E91K			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	91						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						CACACCCAAGGAGGAACACCT	0.572000													51	166					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141093193	141093193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141093193G>A	ENST00000389484.3	-	78	13078	c.12107C>T	c.(12106-12108)cCt>cTt	p.P4036L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4036					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCTCTTTTAGGATTTACTGC	0.378000										TSP Lung(27;0.18)			36	94					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190234049	190234049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190234049C>T	ENST00000367462.3	-	4	795	c.564G>A	c.(562-564)agG>agA	p.R188R	FAM5C_ENST00000534846.1_Silent_p.R86R|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		188						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGGTGCTGTCCCTGTCAATGA	0.443000													43	99					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480105	73480105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73480105C>T	ENST00000523207.1	+	2	724	c.136C>T	c.(136-138)Cac>Tac	p.H46Y		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	46					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GGGCCTCAACCACGAAGTCCT	0.572000													42	79					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996466	140996466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140996466G>A	ENST00000285879.4	+	4	3562	c.3276G>A	c.(3274-3276)aaG>aaA	p.K1092K	MAGEC1_ENST00000406005.2_Silent_p.K159K	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1092	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCATGCTAAAGAATACCGTCC	0.453000										HNSCC(15;0.026)			85	61					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57340662	57340662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57340662G>A	ENST00000361249.3	+	3	308	c.212G>A	c.(211-213)gGa>gAa	p.G71E		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	71	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						AAGTTTGGGGGAACCATCTGC	0.473000													14	31					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713053	46713053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46713053C>T	ENST00000318962.4	-	25	2789	c.2706G>A	c.(2704-2706)gaG>gaA	p.E902E	ALS2CL_ENST00000415953.1_Silent_p.E902E|ALS2CL_ENST00000383742.3_Silent_p.E249E	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	902	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TCAGGTGGATCTCGGCTCCCA	0.612000													15	67					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66192132	66192132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66192132C>T	ENST00000311034.2	+	7	1947	c.1771C>T	c.(1771-1773)Cta>Tta	p.L591L		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	591					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GCTCTTGGCCCTAGCCCAGCT	0.587000													28	109					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41689912	41689912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41689912C>T	ENST00000313860.7	+	24	3046	c.2992C>T	c.(2992-2994)Cct>Tct	p.P998S	LIMCH1_ENST00000513024.1_Intron|LIMCH1_ENST00000396595.3_Intron|LIMCH1_ENST00000381753.4_Intron|LIMCH1_ENST00000512946.1_Intron|LIMCH1_ENST00000514096.1_Intron|LIMCH1_ENST00000509277.1_Missense_Mutation_p.P831S|LIMCH1_ENST00000512820.1_Intron|LIMCH1_ENST00000508501.1_Intron|LIMCH1_ENST00000503057.1_Missense_Mutation_p.P1382S|LIMCH1_ENST00000512632.1_Intron|LIMCH1_ENST00000511496.1_Intron	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	998					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TTCTCCCACCCCTCCCGGTCA	0.483000													24	82					0	0	1	0	0
MMP24	10893	broad.mit.edu	37	20	33851599	33851599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33851599G>A	ENST00000246186.6	+	5	908	c.823G>A	c.(823-825)Gac>Aac	p.D275N	EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000453892.1_RNA|MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000438751.1_RNA|MMP24-AS1_ENST00000433764.1_RNA|MMP24-AS1_ENST00000566203.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	275					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CACAGGGAACGACCTCTTCCT	0.627000													8	9					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	119986065	119986065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119986065G>A	ENST00000341846.5	-	8	2106	c.1685C>T	c.(1684-1686)tCt>tTt	p.S562F	TRIM29_ENST00000529044.1_Missense_Mutation_p.S301F|TRIM29_ENST00000525887.1_5'UTR|TRIM29_ENST00000524816.3_Missense_Mutation_p.S128F|TRIM29_ENST00000528870.1_Missense_Mutation_p.S95F|TRIM29_ENST00000541857.1_Missense_Mutation_p.S295F	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	562					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CTGCTTGCCAGATTTCCAAGT	0.612000													9	24					0	0	1	0	0
OR10H1	26539	broad.mit.edu	37	19	15918200	15918200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15918200G>A	ENST00000334920.2	-	1	736	c.648C>T	c.(646-648)ctC>ctT	p.L216L		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						CATAGGAGAGGAGGATGAGGA	0.577000													21	66					0	0	1	0	0
MECP2	4204	broad.mit.edu	37	X	153296314	153296314	+	Missense_Mutation	SNP	G	G	A	rs63749747		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153296314G>A	ENST00000303391.6	-	4	1214	c.965C>T	c.(964-966)cCc>cTc	p.P322L	MECP2_ENST00000453960.2_Missense_Mutation_p.P334L	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	322			P -> A (in RTT).|P -> L (in RTT).|P -> S (in MRXS13).		negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACCAGCAGGGGCTTCACCAC	0.597000													42	27					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159784074	159784074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159784074G>A	ENST00000321935.6	+	9	1246	c.1160G>A	c.(1159-1161)aGg>aAg	p.R387K	FCRL6_ENST00000392235.3_Missense_Mutation_p.R285K|FCRL6_ENST00000339348.5_Missense_Mutation_p.R380K|FCRL6_ENST00000368106.3_Missense_Mutation_p.R380K			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	380						integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					ACCTCAAAGAGGAGTGAAGGT	0.438000													23	45					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22157590	22157590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:22157590G>A	ENST00000389398.5	+	27	2860	c.2764G>A	c.(2764-2766)Gag>Aag	p.E922K	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	922						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		GACGCCCAGGGAGATGGAGGT	0.587000													3	24					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25296628	25296628	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25296628C>T	ENST00000549804.2	+	0	98				SNHG14_ENST00000547292.1_RNA|SNORD116-1_ENST00000384335.1_RNA|SNHG14_ENST00000552781.1_RNA																							GTGCTTGGATCGATGATGAGT	0.473000													53	126					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205306568	205306568	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205306568G>A	ENST00000367156.3	-	9	1828	c.1012C>T	c.(1012-1014)Ctg>Ttg	p.L338L	KLHDC8A_ENST00000460687.1_Silent_p.L204L|KLHDC8A_ENST00000539253.1_Silent_p.L338L|KLHDC8A_ENST00000537168.1_Silent_p.L225L|KLHDC8A_ENST00000367155.3_Silent_p.L338L	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	338										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCGTCACTCAGACCCTGGTTG	0.577000													32	112					0	0	1	0	0
TRGV3	6976	broad.mit.edu	37	7	38398396	38398396	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38398396C>T	ENST00000390346.2	-	0	253																											CTTCGTTCTCCCTTCCAAGTT	0.438000													19	105					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121577399	121577399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:121577399G>A	ENST00000275159.6	-	16	1765	c.1766C>T	c.(1765-1767)tCg>tTg	p.S589L	TBC1D32_ENST00000398212.2_Missense_Mutation_p.S589L					TBC1 domain family, member 32																		AAGTTTTTTCGAAAACTGGGC	0.338000													12	22					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	86068206	86068206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:86068206G>A	ENST00000373131.1	+	8	1587	c.1424G>A	c.(1423-1425)cGa>cAa	p.R475Q	DACH2_ENST00000508860.1_Missense_Mutation_p.R321Q|DACH2_ENST00000373125.4_Missense_Mutation_p.R488Q|DACH2_ENST00000510272.1_Missense_Mutation_p.R269Q|DACH2_ENST00000477378.2_3'UTR	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	488	DACHbox-C.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						AAGGAGCTGCGACTGGAGCTC	0.413000													15	7					0	0	1	0	0
RAB3IL1	5866	broad.mit.edu	37	11	61672252	61672252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61672252G>A	ENST00000394836.2	-	6	917	c.760C>T	c.(760-762)Ccc>Tcc	p.P254S	RAB3IL1_ENST00000301773.5_Missense_Mutation_p.P228S	NM_013401.2	NP_037533.2	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	254							protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(4)|skin(3)|urinary_tract(1)	14						TCCAGGCAGGGGCCCACGTCC	0.662000													12	7					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327538	57327538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57327538C>T	ENST00000326441.9	-	10	2635	c.2272G>A	c.(2272-2274)Gaa>Aaa	p.E758K	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.E634K|PEG3_ENST00000593695.1_Missense_Mutation_p.E632K|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.E758K	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	758					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCTGGTTTTCATAGGGGTTA	0.413000													75	194					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477162	128477162	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128477162G>A	ENST00000322313.4	-	16	2595	c.2437C>T	c.(2437-2439)Cct>Tct	p.P813S		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	813					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GGAGGGTGAGGTCCTCTCATC	0.617000													12	40					0	0	1	0	0
IKZF4	64375	broad.mit.edu	37	12	56417497	56417497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56417497C>T	ENST00000262032.5	+	6	497	c.130C>T	c.(130-132)Cct>Tct	p.P44S	IKZF4_ENST00000548601.1_Intron|IKZF4_ENST00000547167.1_Missense_Mutation_p.P44S|IKZF4_ENST00000547791.1_Intron|IKZF4_ENST00000431367.2_Intron			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	44					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGATTTCTTGCCTCAGGCCCA	0.448000													10	31					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50279643	50279643	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50279643C>T	ENST00000284509.6	-	10	834	c.693G>A	c.(691-693)ctG>ctA	p.L231L	ATP8B4_ENST00000559829.1_Silent_p.L231L|ATP8B4_ENST00000558959.1_5'UTR	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	231					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGCAGCCTCTCAGGATTATCT	0.448000													29	98					0	0	1	0	0
LHX5	64211	broad.mit.edu	37	12	113907014	113907014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113907014C>T	ENST00000261731.3	-	2	883	c.310G>A	c.(310-312)Gag>Aag	p.E104K		NM_022363.2	NP_071758.1	Q9H2C1	LHX5_HUMAN	LIM homeobox 5	104	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	10						ACGTAGAGCTCCTCGCCGGTG	0.572000													21	48					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76372279	76372279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76372279G>A	ENST00000407242.2	-	3	600	c.358C>T	c.(358-360)Ctg>Ttg	p.L120L	AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000404995.1_Silent_p.L120L|LRRC32_ENST00000464145.1_Intron|LRRC32_ENST00000260061.5_Silent_p.L120L	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	120						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						AGGGGGCCCAGGCCACCAGCA	0.692000													16	41					0	0	1	0	0
GALNT12	79695	broad.mit.edu	37	9	101608265	101608265	+	Missense_Mutation	SNP	G	G	A	rs137917376		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101608265G>A	ENST00000375011.3	+	9	1465	c.1465G>A	c.(1465-1467)Gag>Aag	p.E489K		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	489	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				TTAGTTTTTCGAGTACACGTC	0.478000													5	36					0	0	1	0	0
CD97	976	broad.mit.edu	37	19	14512561	14512561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14512561C>T	ENST00000242786.5	+	11	1252	c.1172C>T	c.(1171-1173)gCc>gTc	p.A391V	CD97_ENST00000358600.3_Missense_Mutation_p.A298V|CD97_ENST00000357355.3_Missense_Mutation_p.A342V	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	391					cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GCAGCTGGAGCCGAGGATCCA	0.607000													4	26					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471756	47471756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:47471756G>A	ENST00000266581.4	-	2	1496	c.1030C>T	c.(1030-1032)Cac>Tac	p.H344Y	AMIGO2_ENST00000429635.1_Missense_Mutation_p.H344Y|AMIGO2_ENST00000550413.1_Missense_Mutation_p.H344Y|AMIGO2_ENST00000321382.3_Missense_Mutation_p.H344Y	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	344	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CTTCCATTGTGAAACACGTAA	0.423000													72	119					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038664	75038664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75038664G>A	ENST00000326665.5	-	14	2948	c.2730C>T	c.(2728-2730)gcC>gcT	p.A910A	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	910	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCAAGTTCAGGGCTGCTGCTT	0.542000													77	227					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20996624	20996624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20996624G>A	ENST00000261383.3	-	48	7439	c.7440C>T	c.(7438-7440)gtC>gtT	p.V2480V	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2480	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGGCCACACCGACCTGCAGTA	0.493000													28	20					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103068524	103068524	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103068524G>A	ENST00000264260.2	+	12	2272	c.1683G>A	c.(1681-1683)gtG>gtA	p.V561V	IL18RAP_ENST00000409369.1_Silent_p.V419V	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	561	TIR.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						ACATGCCTGTGAAAAACTCTC	0.473000													71	144					0	0	1	0	0
ZNF77	58492	broad.mit.edu	37	19	2936611	2936611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2936611G>A	ENST00000314531.4	-	3	314	c.222C>T	c.(220-222)ttC>ttT	p.F74F		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CACTTCCTGTGAACTTTACAA	0.413000													33	61					0	0	1	0	0
TNNT2	7139	broad.mit.edu	37	1	201332429	201332429	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201332429G>A	ENST00000509001.1	-	11	851	c.565C>T	c.(565-567)Cag>Tag	p.Q189*	TNNT2_ENST00000460780.1_5'UTR|TNNT2_ENST00000367317.4_Nonsense_Mutation_p.Q189*|TNNT2_ENST00000360372.4_Nonsense_Mutation_p.Q184*|TNNT2_ENST00000458432.2_Nonsense_Mutation_p.Q201*|TNNT2_ENST00000236918.7_Nonsense_Mutation_p.Q194*|TNNT2_ENST00000367315.2_Nonsense_Mutation_p.Q189*|TNNT2_ENST00000367320.2_Nonsense_Mutation_p.Q159*|TNNT2_ENST00000421663.2_Nonsense_Mutation_p.Q191*|TNNT2_ENST00000367318.5_Nonsense_Mutation_p.Q189*|TNNT2_ENST00000367322.1_Nonsense_Mutation_p.Q189*	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	199			S -> F (in CMH2).		ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						CCTACCTTCTGGATGTAACCC	0.552000													32	224					0	0	1	0	0
ANKRD7	56311	broad.mit.edu	37	7	117876926	117876926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117876926G>A	ENST00000357099.4	+	6	891	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K	ANKRD7_ENST00000433239.1_Missense_Mutation_p.E167K|ANKRD7_ENST00000417525.1_Missense_Mutation_p.E167K|ANKRD7_ENST00000265224.4_Missense_Mutation_p.E220K|ANKRD7_ENST00000477532.1_3'UTR			Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	220					male gonad development					breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)	29						ATTATGTTACGAAGGTATTGT	0.393000													73	210					0	0	1	0	0
CPSF6	11052	broad.mit.edu	37	12	69652691	69652691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:69652691C>T	ENST00000435070.2	+	6	1126	c.1016C>T	c.(1015-1017)cCt>cTt	p.P339L	CPSF6_ENST00000456847.3_Missense_Mutation_p.P266L|CPSF6_ENST00000266679.8_Missense_Mutation_p.P376L|CPSF6_ENST00000551516.1_Intron	NM_007007.2	NP_008938.2	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6, 68kDa	339	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(7)|lung(8)	16	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			ACACTAGCTCCTCCTCCGCAT	0.627000													41	172					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580008	140580008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580008C>T	ENST00000354757.3	+	1	661	c.661C>T	c.(661-663)Ccc>Tcc	p.P221S	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		221	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGGTCCCCTCCCAGGTCTGG	0.512000													37	100					0	0	1	0	0
ZNF136	7695	broad.mit.edu	37	19	12297482	12297482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12297482C>T	ENST00000343979.4	+	4	429	c.289C>T	c.(289-291)Cct>Tct	p.P97S	ZNF136_ENST00000398616.2_Missense_Mutation_p.P31S	NM_003437.3	NP_003428.1	P52737	ZN136_HUMAN	zinc finger protein 136	97					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			NS(1)|biliary_tract(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	18						CAAGAAAATCCCTGGAGTGAA	0.403000													23	73					0	0	1	0	0
CA3	761	broad.mit.edu	37	8	86358415	86358415	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:86358415C>T	ENST00000285381.2	+	6	635	c.552C>T	c.(550-552)ttC>ttT	p.F184F	RP11-317J10.2_ENST00000517697.1_RNA|RP11-317J10.2_ENST00000521761.1_RNA	NM_005181.3	NP_005172.1	P07451	CAH3_HUMAN	carbonic anhydrase III, muscle specific	184					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						CCTGCCTGTTCCCGGCATGCC	0.607000													8	20					0	0	1	0	0
BFSP2	8419	broad.mit.edu	37	3	133119161	133119161	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133119161C>T	ENST00000302334.2	+	1	323	c.234C>T	c.(232-234)ctC>ctT	p.L78L		NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	78	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						GCCGGGCCCTCGGCATCAGCA	0.647000													19	71					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120601056	120601056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120601056G>A	ENST00000300648.6	-	19	1868	c.1856C>T	c.(1855-1857)cCc>cTc	p.P619L		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	619					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGCCTCTAAGGGCAGCACCTG	0.572000													14	33					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327800	85327800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85327800C>T	ENST00000299927.3	+	1	1916	c.1894C>T	c.(1894-1896)Ctg>Ttg	p.L632L	ZNF592_ENST00000560079.2_Silent_p.L632L			Q92610	ZN592_HUMAN	zinc finger protein 592	632					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAAGTGCAGCCTGCTCCGGCA	0.592000													33	78					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179431928	179431928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179431928G>A	ENST00000589042.1	-	326	79155	c.78931C>T	c.(78931-78933)Cca>Tca	p.P26311S	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P23743S|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P24670S|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P17438S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P17371S|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P17246S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24670	Fibronectin type-III 91.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTGAAGTGGTGGAGACCAT	0.448000													47	158					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189025997	189025997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189025997C>T	ENST00000512729.1	-	2	503	c.129G>A	c.(127-129)atG>atA	p.M43I	TRIML2_ENST00000536972.1_Missense_Mutation_p.M93I|TRIML2_ENST00000326754.3_Missense_Mutation_p.M43I	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	43							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TGACCTGAATCATCGCCATTC	0.358000													35	103					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165179969	165179969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165179969G>A	ENST00000342310.3	-	6	1096	c.714C>T	c.(712-714)gtC>gtT	p.V238V	LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Silent_p.V238V|LMX1A_ENST00000367893.4_Silent_p.V238V|RP11-38C18.2_ENST00000457106.1_RNA	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	238						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.V238V(1)		NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					ACACCTGGACGACACGGACAC	0.483000													18	35					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78943275	78943275	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:78943275C>T	ENST00000286627.5	-	5	1664	c.712G>A	c.(712-714)Gat>Aat	p.D238N	KCNMA1_ENST00000372440.1_Missense_Mutation_p.D238N|KCNMA1_ENST00000354353.5_Missense_Mutation_p.D238N|KCNMA1_ENST00000404857.1_Missense_Mutation_p.D238N|KCNMA1_ENST00000406533.3_Missense_Mutation_p.D238N|KCNMA1_ENST00000286628.8_Missense_Mutation_p.D238N|KCNMA1_ENST00000404771.3_Missense_Mutation_p.D238N|KCNMA1_ENST00000372443.1_Missense_Mutation_p.D238N	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	238					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CACAATTTATCGTTGGCTGCA	0.428000													7	24					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170235640	170235640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:170235640G>A	ENST00000518525.1	+	9	1180	c.716G>A	c.(715-717)cGg>cAg	p.R239Q	GABRP_ENST00000519385.1_Missense_Mutation_p.R239Q|GABRP_ENST00000265294.4_Missense_Mutation_p.R239Q|GABRP_ENST00000519598.1_Missense_Mutation_p.R239Q			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	239						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTTGAGCTTCGGAGGAATGTT	0.423000													21	59					0	0	1	0	0
NR5A1	2516	broad.mit.edu	37	9	127262850	127262850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127262850G>A	ENST00000373588.4	-	4	585	c.389C>T	c.(388-390)cCg>cTg	p.P130L		NM_004959.4	NP_004950.2	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	130					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			lung(1)|upper_aerodigestive_tract(1)	2						AGGGGGCGGCGGGGGCACCCC	0.701000													5	25					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104948865	104948865	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:104948865G>A	ENST00000507740.1	+	10	2074	c.1838G>A	c.(1837-1839)cGa>cAa	p.R613Q	RIMS2_ENST00000262231.10_Missense_Mutation_p.R660Q|RIMS2_ENST00000406091.3_Missense_Mutation_p.R821Q|RIMS2_ENST00000436393.2_Missense_Mutation_p.R599Q	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	883					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.R613Q(3)|p.R888Q(3)|p.R599Q(3)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCAGTCCACCGAAGAGAATTT	0.388000										HNSCC(12;0.0054)			36	123					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242757862	242757862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242757862G>A	ENST00000391969.2	+	5	1654	c.943G>A	c.(943-945)Gaa>Aaa	p.E315K	NEU4_ENST00000405370.1_Missense_Mutation_p.E315K|NEU4_ENST00000404257.1_Missense_Mutation_p.E327K|NEU4_ENST00000407683.1_Missense_Mutation_p.E315K|NEU4_ENST00000325935.6_Missense_Mutation_p.E328K	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	315	Pro-rich.					lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		TGGAGTCCACGAACCCCCAGA	0.716000													3	21					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70229978	70229978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:70229978G>A	ENST00000342771.4	+	8	1776	c.1455G>A	c.(1453-1455)ggG>ggA	p.G485G	AUTS2_ENST00000406775.2_Silent_p.G485G	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	485										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		ACCCGGCCGGGAGCACTTACT	0.627000													10	45					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153749612	153749612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153749612C>T	ENST00000271857.2	+	3	2096	c.1336C>T	c.(1336-1338)Cac>Tac	p.H446Y	SLC27A3_ENST00000368661.3_Missense_Mutation_p.H365Y|SLC27A3_ENST00000484014.1_3'UTR			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	365					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTGTGGTGTCCACCAGGAAGA	0.587000													36	105					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126531810	126531810	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126531810G>A	ENST00000373624.2	-	4	366	c.165C>T	c.(163-165)ttC>ttT	p.F55F	DENND1A_ENST00000373618.1_Intron|DENND1A_ENST00000394215.2_Silent_p.F25F|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000373620.3_Silent_p.F55F|DENND1A_ENST00000394219.3_Silent_p.F23F	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	55	UDENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CATAGAAGGGGAAACAAAACT	0.338000													35	90					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9100069	9100069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9100069C>T	ENST00000383836.3	-	7	1316	c.889G>A	c.(889-891)Gaa>Aaa	p.E297K	SRGAP3_ENST00000433332.3_5'UTR|SRGAP3_ENST00000360413.3_Missense_Mutation_p.E297K	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	297					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCCAGCCCTTCGTGGCGAGAG	0.552000			T	RAF1	pilocytic astrocytoma								54	116					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202704705	202704705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202704705G>A	ENST00000367265.3	-	22	4439	c.3275C>T	c.(3274-3276)cCt>cTt	p.P1092L	KDM5B_ENST00000367264.2_Missense_Mutation_p.P1128L	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1092					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						ATCACATCGAGGACACAGCAC	0.388000													29	49					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18258340	18258340	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18258340G>A	ENST00000286479.3	+	2	934	c.827G>A	c.(826-828)gGg>gAg	p.G276E	NAT2_ENST00000520116.1_Missense_Mutation_p.G146E	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	276					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		ATTTCCTTGGGGAGAAATCTC	0.358000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				21	56					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94032059	94032059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94032059G>A	ENST00000282020.4	+	4	948	c.690G>A	c.(688-690)gcG>gcA	p.A230A	GRID2_ENST00000510992.1_Silent_p.A135A|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	230					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TTAGGCGAGCGATCCTTGTTA	0.383000													24	100					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19571806	19571806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:19571806C>T	ENST00000507958.1	-	10	2125	c.1135G>A	c.(1135-1137)Gaa>Aaa	p.E379K	CDH18_ENST00000506372.1_Missense_Mutation_p.E379K|CDH18_ENST00000382275.1_Missense_Mutation_p.E379K|CDH18_ENST00000274170.4_Missense_Mutation_p.E379K|CDH18_ENST00000502796.1_Missense_Mutation_p.E379K|CDH18_ENST00000511273.1_Missense_Mutation_p.E379K			Q13634	CAD18_HUMAN	cadherin 18, type 2	379	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGTGGTGGTTCATCTACATCC	0.428000													19	69					0	0	1	0	0
DLL3	10683	broad.mit.edu	37	19	39994874	39994874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39994874C>T	ENST00000205143.4	+	5	823	c.816C>T	c.(814-816)gtC>gtT	p.V272V	DLL3_ENST00000356433.5_Silent_p.V272V	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	272					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GATGCCTTGTCCCTGGGCCTG	0.642000													22	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179629027	179629027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179629027G>A	ENST00000589042.1	-	43	10215	c.9991C>T	c.(9991-9993)Cca>Tca	p.P3331S	TTN_ENST00000342992.6_Missense_Mutation_p.P3331S|TTN_ENST00000360870.5_Missense_Mutation_p.P3331S|TTN_ENST00000591111.1_Missense_Mutation_p.P3331S|TTN_ENST00000342175.6_Missense_Mutation_p.P3285S|TTN_ENST00000359218.5_Missense_Mutation_p.P3285S|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P3285S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3056							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAACTTCTGGAACTAAAGAA	0.448000													14	31					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66811188	66811188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66811188G>A	ENST00000393946.2	+	8	1863	c.701G>A	c.(700-702)aGc>aAc	p.S234N	SYT12_ENST00000527043.1_Missense_Mutation_p.S234N|SYT12_ENST00000525457.1_Missense_Mutation_p.S234N			Q8IV01	SYT12_HUMAN	synaptotagmin XII	234	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						GAGGAGAAGAGCCTGCGGTTT	0.557000													36	70					0	0	1	0	0
DMRT1	1761	broad.mit.edu	37	9	916880	916880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:916880C>T	ENST00000382276.3	+	4	1089	c.940C>T	c.(940-942)Ccc>Tcc	p.P314S	DMRT1_ENST00000569227.1_Missense_Mutation_p.P156S	NM_021951.2	NP_068770.2	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor 1	314					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(10)|ovary(1)	13		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		TGAGGATGCTCCCTCTTACCC	0.557000													8	79					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13323499	13323499	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13323499C>T	ENST00000360228.5	-	41	5995	c.5996G>A	c.(5995-5997)gGg>gAg	p.G1999E	CACNA1A_ENST00000573710.2_Missense_Mutation_p.G2000E	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	2000					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCCAGGTCCCCCTTCCTGCGT	0.687000													6	8					0	0	1	0	0
KHDC1L	100129128	broad.mit.edu	37	6	73935101	73935101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73935101C>T	ENST00000370388.3	-	1	74	c.31G>A	c.(31-33)Gag>Aag	p.E11K	KHDC1L_ENST00000471312.1_5'UTR|RP11-257K9.8_ENST00000423730.3_Silent_p.R113R	NM_001126063.2	NP_001119535.1	Q5JSQ8	KHDCL_HUMAN	KH homology domain containing 1-like	11										breast(1)|endometrium(1)|kidney(1)|lung(3)|skin(1)	7						CACCACGGCTCCTTGCTGAGA	0.537000													8	48					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130911970	130911970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130911970G>A	ENST00000409031.1	-	16	2804	c.1656C>T	c.(1654-1656)ttC>ttT	p.F552F	SMPD4_ENST00000426662.2_Silent_p.F188F|SMPD4_ENST00000351288.6_Silent_p.F523F|SMPD4_ENST00000453750.1_Silent_p.F301F|SMPD4_ENST00000431183.2_Silent_p.F450F|SMPD4_ENST00000339679.7_Silent_p.F410F|SMPD4_ENST00000443958.2_Silent_p.F216F|SMPD4_ENST00000452225.2_Silent_p.F293F	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	513					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	AGGGTGACAGGAAGCTCCCAG	0.607000													6	11					0	0	1	0	0
OR5V1	81696	broad.mit.edu	37	6	29323644	29323644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29323644G>A	ENST00000377154.1	-	4	628	c.329C>T	c.(328-330)tCa>tTa	p.S110L	OR5V1_ENST00000543825.1_Missense_Mutation_p.S110L			Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V, member 1	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(3)|large_intestine(3)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GAGACACTCTGATCCTACAAA	0.403000													28	68					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99564686	99564686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99564686G>A	ENST00000292401.4	-	4	973	c.837C>T	c.(835-837)tcC>tcT	p.S279S	AZGP1_ENST00000411734.1_3'UTR|AZGP1_ENST00000483612.1_5'UTR	NM_001185.3	NP_001176.1	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	279	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					GCACGTGGCAGGAGTAGGGGG	0.622000													35	106					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89251666	89251666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89251666G>A	ENST00000289746.2	+	5	653	c.588G>A	c.(586-588)caG>caA	p.Q196Q		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	196	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		TCCTGCAGCAGGGCAGCCCCG	0.667000													3	7					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74863238	74863238	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:74863238C>T	ENST00000358399.3	+	14	1438	c.1345C>T	c.(1345-1347)Ccg>Tcg	p.P449S	GDA_ENST00000238018.4_Missense_Mutation_p.P449S|GDA_ENST00000376986.1_Missense_Mutation_p.P371S|GDA_ENST00000376989.3_Missense_Mutation_p.P388S|GDA_ENST00000545168.1_Missense_Mutation_p.P375S	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	449					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GCAGGTGGTTCCGTTTTCCAG	0.448000													24	97					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34102044	34102044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34102044C>T	ENST00000373381.4	-	30	5061	c.4885G>A	c.(4885-4887)Gaa>Aaa	p.E1629K	CSMD2_ENST00000373380.1_Missense_Mutation_p.E502K|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1589	CUB 10.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCTCAACTTCGTAGCCCCCG	0.622000													12	29					0	0	1	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474889	20474889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20474889C>T	ENST00000375102.3	+	5	733	c.631C>T	c.(631-633)Ccc>Tcc	p.P211S		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	168					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CCCCGCCCCTCCCTAGAGCCT	0.657000													9	48					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233273254	233273254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233273254C>T	ENST00000295453.3	+	7	879	c.827C>T	c.(826-828)tCc>tTc	p.S276F		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	276					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CTGCAGGCTTCCCTGGACCCG	0.652000													35	98					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599756	29599756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29599756G>A	ENST00000431530.3	+	1	1009	c.951G>A	c.(949-951)gaG>gaA	p.E317E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	307						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GAAAGGGAGAGGCCAAGCTGG	0.502000													17	28					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46243823	46243823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:46243823C>T	ENST00000334344.6	+	15	2089	c.1917C>T	c.(1915-1917)atC>atT	p.I639I	ARID2_ENST00000422737.1_Silent_p.I490I|ARID2_ENST00000444670.1_Silent_p.I249I|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	639					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTTCAGGAATCCCTCATGGAT	0.338000			"""N, S, F"""		hepatocellular carcinoma								36	54					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27963289	27963289	+	Silent	SNP	G	G	A	rs150233755	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:27963289G>A	ENST00000269033.3	-	14	2029	c.1878C>T	c.(1876-1878)tcC>tcT	p.S626S	SSH2_ENST00000540801.1_Silent_p.S653S|RP11-68I3.2_ENST00000581474.1_RNA	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	626					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CAGGATCAGGGGACATGGGGG	0.478000													8	72					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123267179	123267179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123267179C>T	ENST00000451558.1	+	11	1234	c.713C>T	c.(712-714)gCt>gTt	p.A238V	ASB15_ENST00000434204.1_Missense_Mutation_p.A238V|ASB15_ENST00000451215.1_Missense_Mutation_p.A238V|ASB15_ENST00000275699.3_Missense_Mutation_p.A238V|ASB15_ENST00000540573.1_Missense_Mutation_p.A238V			Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box containing 15	238					intracellular signal transduction					breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(3)	12						GATGTGCTTGCTTTGGCGGAT	0.507000													20	107					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94993239	94993239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94993239C>T	ENST00000265627.5	-	6	641	c.631G>A	c.(631-633)Gag>Aag	p.E211K	PON1_ENST00000542556.1_Intron|PON3_ENST00000427422.1_Missense_Mutation_p.E211K	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			ACTTTAACCTCCCTTGGGCTG	0.438000													79	196					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48713025	48713025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:48713025G>A	ENST00000236495.5	+	15	1981	c.1931G>A	c.(1930-1932)gGa>gAa	p.G644E	SLC5A9_ENST00000471020.1_3'UTR|SLC5A9_ENST00000438567.2_Missense_Mutation_p.G619E|SLC5A9_ENST00000533824.1_Missense_Mutation_p.G640E	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	619						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						AGGTCCTGGGGAAAGTTGCTC	0.557000													9	26					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657106	143657106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143657106C>T	ENST00000392899.1	+	1	80	c.43C>T	c.(43-45)Ctc>Ttc	p.L15F		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					ATTTATTCTCCTCGGCCTGTC	0.453000													59	136					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	8009922	8009922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8009922C>T	ENST00000318888.4	-	15	1456	c.585G>A	c.(583-585)aaG>aaA	p.K195K	ABLIM2_ENST00000296372.8_Silent_p.K461K|ABLIM2_ENST00000428004.2_Silent_p.K420K|ABLIM2_ENST00000514025.1_Silent_p.K195K|ABLIM2_ENST00000546334.1_Silent_p.K419K|ABLIM2_ENST00000361737.5_Silent_p.K419K|ABLIM2_ENST00000361581.5_Silent_p.K460K|ABLIM2_ENST00000545242.1_Silent_p.K460K|ABLIM2_ENST00000341937.5_Silent_p.K460K|ABLIM2_ENST00000505872.1_Silent_p.K408K|ABLIM2_ENST00000407564.3_Silent_p.K409K|ABLIM2_ENST00000447017.2_Silent_p.K494K			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	460	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						GCCAGCTGCTCTTCTGCTGAA	0.512000													13	68					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51258589	51258589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:51258589C>T	ENST00000395542.2	-	4	827	c.643G>A	c.(643-645)Gag>Aag	p.E215K	COBL_ENST00000441453.1_Missense_Mutation_p.E215K|COBL_ENST00000265136.7_Missense_Mutation_p.E215K|COBL_ENST00000395540.2_Missense_Mutation_p.E215K			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	215										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					ATCCCGAGCTCGTTCAGGGAC	0.592000													8	35					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148406911	148406911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148406911G>A	ENST00000538184.1	-	7	1913	c.1025C>T	c.(1024-1026)tCc>tTc	p.S342F	SH3TC2_ENST00000512049.1_Missense_Mutation_p.S788F|SH3TC2_ENST00000515425.1_Missense_Mutation_p.S795F|SH3TC2_ENST00000394358.2_Missense_Mutation_p.S680F			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	795							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACTCAAAGGATTCCTGCTC	0.567000													11	89					0	0	1	0	0
ITPRIPL1	150771	broad.mit.edu	37	2	96992898	96992898	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96992898C>T	ENST00000361124.4	+	1	964	c.553C>T	c.(553-555)Caa>Taa	p.Q185*	ITPRIPL1_ENST00000536814.1_Nonsense_Mutation_p.Q169*|ITPRIPL1_ENST00000439118.2_Nonsense_Mutation_p.Q177*|ITPRIPL1_ENST00000542887.1_Nonsense_Mutation_p.Q169*	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	177						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ACACTATGTCCAAAATGCCAT	0.547000													49	129					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198126	20198126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20198126C>T	ENST00000400331.5	-	5	2166	c.1858G>A	c.(1858-1860)Gag>Aag	p.E620K	MACC1_ENST00000332878.4_Missense_Mutation_p.E620K|MACC1_ENST00000589011.1_Missense_Mutation_p.E620K	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	620					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						ATTACTTGCTCCTTTGAAATC	0.358000													54	163					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79750470	79750470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79750470C>T	ENST00000305428.3	+	2	2056	c.1981C>T	c.(1981-1983)Ccc>Tcc	p.P661S		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	661						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CAGTGCCTCTCCCCGGATGTT	0.527000													108	132					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138978066	138978066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138978066C>T	ENST00000288561.8	+	16	3758	c.3509C>T	c.(3508-3510)cCt>cTt	p.P1170L	UBN2_ENST00000473989.2_Missense_Mutation_p.P1253L	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1253	Ser-rich.									NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						AATGTGACTCCTTTTGGGATG	0.488000													46	89					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987862	50987862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50987862C>T	ENST00000395676.2	+	1	1401	c.1267C>T	c.(1267-1269)Ccg>Tcg	p.P423S		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	423										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTGCTACGACCCGCGAACAGA	0.687000													24	109					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49386169	49386169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49386169G>A	ENST00000374201.3	-	22	3118	c.2816C>T	c.(2815-2817)tCa>tTa	p.S939L	FRMPD2_ENST00000407470.4_Missense_Mutation_p.S907L|FRMPD2_ENST00000305531.3_Missense_Mutation_p.S914L|FRMPD2_ENST00000463706.1_5'UTR	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	939					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		TTCTGGAGGTGATGGAGGACA	0.423000													12	27					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191051	6191051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6191051G>A	ENST00000530810.1	-	1	587	c.506C>T	c.(505-507)cCc>cTc	p.P169L	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGGCAGAAGGGCAGCCGCTT	0.502000													4	36					0	0	1	0	0
VOPP1	81552	broad.mit.edu	37	7	55565375	55565375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55565375G>A	ENST00000285279.5	-	3	322	c.122C>T	c.(121-123)tCc>tTc	p.S41F	VOPP1_ENST00000454227.1_Intron|VOPP1_ENST00000428097.1_5'UTR|VOPP1_ENST00000453256.1_5'UTR|VOPP1_ENST00000418904.1_Missense_Mutation_p.S24F|VOPP1_ENST00000428648.1_5'UTR|VOPP1_ENST00000471168.1_5'UTR|VOPP1_ENST00000433959.1_Missense_Mutation_p.S32F|VOPP1_ENST00000427700.1_Missense_Mutation_p.S39F|VOPP1_ENST00000545390.1_Missense_Mutation_p.S38F	NM_030796.3	NP_110423.3	Q96AW1	VOPP1_HUMAN	vesicular, overexpressed in cancer, prosurvival protein 1	41					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity			endometrium(1)|lung(4)	5						GTCCTCGTAGGAGCGGCATCT	0.592000													25	51					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100530112	100530112	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100530112C>T	ENST00000457717.1	+	13	2003	c.1747C>T	c.(1747-1749)Cta>Tta	p.L583L	MTTP_ENST00000511045.1_Silent_p.L610L|MTTP_ENST00000265517.5_Silent_p.L583L|RP11-766F14.1_ENST00000508578.1_RNA	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	583	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TCAAGACATCCTACGTTTTGA	0.403000													30	110					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566685	136566685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136566685C>T	ENST00000264162.2	-	8	3242	c.3232G>A	c.(3232-3234)Gaa>Aaa	p.E1078K		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1078	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGGGGAAATTCCCCTGAGCCA	0.507000													16	28					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646362	57646362	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57646362C>T	ENST00000269834.1	-	5	1728	c.1343G>A	c.(1342-1344)gGa>gAa	p.G448E		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCAGAACATCCATAAGGTTT	0.408000													51	165					0	0	1	0	0
TBC1D15	64786	broad.mit.edu	37	12	72316862	72316862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72316862C>T	ENST00000550746.1	+	18	2018	c.1954C>T	c.(1954-1956)Cct>Tct	p.P652S	TBC1D15_ENST00000319106.8_Missense_Mutation_p.P643S|TBC1D15_ENST00000393309.3_Missense_Mutation_p.P406S|TBC1D15_ENST00000485960.2_Missense_Mutation_p.P635S	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	652							protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGTCATGACTCCTTGTCCTAC	0.473000													49	121					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220353814	220353814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220353814G>A	ENST00000312358.7	+	35	8320	c.8188G>A	c.(8188-8190)Gac>Aac	p.D2730N	SPEG_ENST00000485813.1_3'UTR|AC053503.11_ENST00000429882.1_RNA	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2730	Fibronectin type-III 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGGCATCCCCGACTGTTACTA	0.632000													43	71					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121228689	121228689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121228689G>A	ENST00000297848.3	+	14	1967	c.1697G>A	c.(1696-1698)cGa>cAa	p.R566Q	COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.R566Q|COL14A1_ENST00000247781.3_Missense_Mutation_p.R471Q	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	566	Fibronectin type-III 4.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATGGTTATCGAATTGTATAT	0.403000													37	91					0	0	1	0	0
FBXW9	84261	broad.mit.edu	37	19	12802014	12802014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12802014G>A	ENST00000380339.3	-	5	885	c.849C>T	c.(847-849)acC>acT	p.T283T	FBXW9_ENST00000393261.3_Silent_p.T283T|FBXW9_ENST00000587955.1_Silent_p.T273T|FBXW9_ENST00000544494.1_Silent_p.T21T			Q5XUX1	FBXW9_HUMAN	F-box and WD repeat domain containing 9	283							protein binding			cervix(1)|lung(4)|ovary(1)|prostate(1)	7						TCTTGTCATAGGTGCCAGTCA	0.607000													39	112					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769146	57769146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57769146G>A	ENST00000371030.2	+	1	3072	c.3072G>A	c.(3070-3072)ggG>ggA	p.G1024G		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1024						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AGTTGGGGGGGGACAAGGGGG	0.682000													10	17					0	0	1	0	0
NPHP1	4867	broad.mit.edu	37	2	110901148	110901148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:110901148G>A	ENST00000316534.4	-	16	1741	c.1668C>T	c.(1666-1668)tcC>tcT	p.S556S	NPHP1_ENST00000393272.3_Silent_p.S555S|NPHP1_ENST00000355301.4_Silent_p.S437S|NPHP1_ENST00000417665.1_Silent_p.S499S|NPHP1_ENST00000445609.2_Silent_p.S500S			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	555					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						TTCTGTTCAAGGATCTCAGTT	0.413000													7	100					0	0	1	0	0
TPTEP1	387590	broad.mit.edu	37	22	17119611	17119611	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17119611C>T	ENST00000426585.1	+	0	423																											GGATGTTCTTCTTCGAGTATT	0.358000													21	48					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56244352	56244352	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56244352T>C	ENST00000332836.2	-	2	872	c.845A>G	c.(844-846)aAa>aGa	p.K282R		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	282	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AAAATAGTGTTTTTGCATAGC	0.403000													28	71					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055529	75055529	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75055529C>T	ENST00000326665.5	-	12	2180	c.1962G>A	c.(1960-1962)gtG>gtA	p.V654V	C1orf173_ENST00000420661.2_Silent_p.V457V|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	654	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GCTTGGTCTCCACATCTGCTT	0.398000													21	95					0	0	1	0	0
C11orf74	119710	broad.mit.edu	37	11	36654959	36654959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:36654959C>T	ENST00000446510.2	+	3	361	c.262C>T	c.(262-264)Cgt>Tgt	p.R88C	C11orf74_ENST00000334307.5_Missense_Mutation_p.R88C|C11orf74_ENST00000347206.4_Intron|C11orf74_ENST00000534635.1_Intron			Q86VG3	CK074_HUMAN	chromosome 11 open reading frame 74	88										breast(1)|kidney(1)|large_intestine(1)|lung(5)	8	all_lung(20;0.226)	all_hematologic(20;0.0118)				CATCTTTCTTCGTACTTCATC	0.308000													10	37					0	0	1	0	0
TLK2	11011	broad.mit.edu	37	17	60631029	60631029	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60631029C>T	ENST00000582809.1	+	10	889	c.186C>T	c.(184-186)gaC>gaT	p.D62D	TLK2_ENST00000326270.9_Silent_p.D211D|TLK2_ENST00000542523.1_Silent_p.D179D|TLK2_ENST00000343388.7_Silent_p.D179D|TLK2_ENST00000346027.5_Silent_p.D211D			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	211					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						TGTAGTCCGACCTCACAATAG	0.348000													22	76					0	0	1	0	0
GPRC5C	55890	broad.mit.edu	37	17	72443165	72443165	+	Nonstop_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72443165T>G	ENST00000392627.1	+	4	2585	c.1459T>G	c.(1459-1461)Tga>Gga	p.*487G	GPRC5C_ENST00000342648.5_Nonstop_Mutation_p.*127G|GPRC5C_ENST00000392629.2_Nonstop_Mutation_p.*454G|GPRC5C_ENST00000582873.1_3'UTR|GPRC5C_ENST00000481232.1_3'UTR	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	0						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						CGTGTGGGACTGAGTCAGCGG	0.667000													30	84					0	0	1	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6529206	6529206	+	Silent	SNP	C	C	T	rs79066520	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6529206C>T	ENST00000377748.1	-	20	2873	c.2376G>A	c.(2374-2376)gaG>gaA	p.E792E	PLEKHG5_ENST00000544978.1_Silent_p.E715E|PLEKHG5_ENST00000537245.1_Silent_p.E794E|PLEKHG5_ENST00000377737.2_Silent_p.E715E|PLEKHG5_ENST00000400913.1_Silent_p.E715E|PLEKHG5_ENST00000377725.1_Silent_p.E715E|PLEKHG5_ENST00000535355.1_Silent_p.E784E|PLEKHG5_ENST00000377728.3_Silent_p.E715E|PLEKHG5_ENST00000377740.3_Silent_p.E792E|PLEKHG5_ENST00000377732.1_Silent_p.E752E|PLEKHG5_ENST00000340850.5_Silent_p.E715E|PLEKHG5_ENST00000400915.3_Silent_p.E771E	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	771					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		cctcctcctcctcttcctcct	0.637000													17	72					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9101810	9101810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9101810G>A	ENST00000377414.3	-	5	672	c.605C>T	c.(604-606)cCc>cTc	p.P202L	SLC2A5_ENST00000377424.4_Intron|SLC2A5_ENST00000536305.1_Intron|SLC2A5_ENST00000535586.1_Intron	NM_001135585.1	NP_001129057.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	35				P -> G (in Ref. 2; AAB60641).	carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGGTGAAGGGGTGGGGGTG	0.542000													11	47					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44640922	44640922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44640922G>A	ENST00000372330.3	+	7	1163	c.1144G>A	c.(1144-1146)Gac>Aac	p.D382N		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	382	Fibronectin type-II 3.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CTTTGACAGCGACAAGAAGTG	0.667000													36	83					0	0	1	0	0
PI16	221476	broad.mit.edu	37	6	36930864	36930864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36930864C>T	ENST00000373674.3	+	5	1074	c.746C>T	c.(745-747)tCa>tTa	p.S249L	PI16_ENST00000491324.1_Intron	NM_001199159.1|NM_153370.2	NP_001186088.1|NP_699201.2	Q6UXB8	PI16_HUMAN	peptidase inhibitor 16	249						extracellular region|integral to membrane	peptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACAGAGGTCTCAGGCTCCCTG	0.577000													9	155					0	0	1	0	0
GPR162	27239	broad.mit.edu	37	12	6933226	6933226	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6933226C>T	ENST00000311268.3	+	2	949	c.162C>T	c.(160-162)ttC>ttT	p.F54F	GPR162_ENST00000382315.3_Intron|GPR162_ENST00000428545.2_Intron|GPR162_ENST00000541431.1_3'UTR	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	54						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						TGCTCTGCTTCCTAGCGGGCA	0.612000													6	38					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38592720	38592720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38592720C>T	ENST00000413689.1	-	28	5336	c.5143G>A	c.(5143-5145)Ggc>Agc	p.G1715S	SCN5A_ENST00000423572.2_Missense_Mutation_p.G1714S|SCN5A_ENST00000425664.1_Missense_Mutation_p.G1697S|SCN5A_ENST00000333535.4_Missense_Mutation_p.G1715S|SCN5A_ENST00000451551.2_Missense_Mutation_p.G1661S|SCN5A_ENST00000455624.2_Missense_Mutation_p.G1682S|SCN5A_ENST00000449557.2_Missense_Mutation_p.G1661S|SCN5A_ENST00000450102.2_Missense_Mutation_p.G1661S|SCN5A_ENST00000443581.1_Missense_Mutation_p.G1714S|SCN5A_ENST00000414099.2_Missense_Mutation_p.G1697S	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1715					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CTGAGGAGGCCATCCCAGCCG	0.642000													38	108					0	0	1	0	0
NRM	11270	broad.mit.edu	37	6	30658642	30658642	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30658642C>T	ENST00000259953.4	-	2	461	c.110G>A	c.(109-111)gGg>gAg	p.G37E	NRM_ENST00000376420.5_Missense_Mutation_p.G37E|NRM_ENST00000470733.1_5'UTR|NRM_ENST00000376421.5_Missense_Mutation_p.G37E	NM_001270707.1	NP_001257636.1	Q8IXM6	NRM_HUMAN	nurim (nuclear envelope membrane protein)	37						integral to membrane|nuclear inner membrane				large_intestine(1)|lung(2)	3						CTCCGGGATCCCTCCAAGAAG	0.632000													35	164					0	0	1	0	0
UBL3	5412	broad.mit.edu	37	13	30351346	30351346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:30351346G>A	ENST00000380680.4	-	2	1227	c.82C>T	c.(82-84)Cct>Tct	p.P28S		NM_007106.3	NP_009037.1	O95164	UBL3_HUMAN	ubiquitin-like 3	28	Ubiquitin-like.			P -> H (in Ref. 5; AAH44582).		intracellular|plasma membrane				large_intestine(3)|lung(1)	4		Lung SC(185;0.0281)		all cancers(112;0.0598)|GBM - Glioblastoma multiforme(144;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.147)		GAATCGTTAGGAGAAAACAGG	0.318000													8	80					0	0	1	0	0
TAL1	6886	broad.mit.edu	37	1	47685725	47685725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47685725C>T	ENST00000371883.3	-	4	1245	c.669G>A	c.(667-669)aaG>aaA	p.K223K	TAL1_ENST00000459729.1_5'UTR|TAL1_ENST00000371884.2_Silent_p.K221K|TAL1_ENST00000294339.3_Silent_p.K221K			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	221	Helix-loop-helix motif.				basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						TGCTGAGCTTCTTGTCCGGGG	0.597000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								13	68					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7091658	7091658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7091658G>A	ENST00000299481.4	+	11	3463	c.3117G>A	c.(3115-3117)aaG>aaA	p.K1039K		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	1039					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AAGTCTTGAAGTCTCCTAAGT	0.388000													35	60					0	0	1	0	0
GJA10	84694	broad.mit.edu	37	6	90604284	90604284	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:90604284C>T	ENST00000369352.1	+	1	97	c.97C>T	c.(97-99)Cga>Tga	p.R33*		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	33					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		CTTCATCTTCCGAATGCTGGT	0.507000													54	58					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29056049	29056049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29056049C>T	ENST00000257189.4	+	16	2909	c.2826C>T	c.(2824-2826)tcC>tcT	p.S942S		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	942					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTTCTGGTTCCCTCGTGCAAC	0.507000													31	106					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4201467	4201467	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4201467C>T	ENST00000404826.2	+	32	4918	c.4779C>T	c.(4777-4779)tcC>tcT	p.S1593S	SDK1_ENST00000389531.3_Silent_p.S1593S	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1593	Fibronectin type-III 10.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACACCACGTCCTCTGTCCTGA	0.562000													44	116					0	0	1	0	0
ATP8B5P	158381	broad.mit.edu	37	9	35449604	35449604	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35449604C>T	ENST00000430846.1	+	0	2468																											AGACATACTTCCCTTCCTTTC	0.353000													3	7					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507520	74507520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:74507520C>T	ENST00000354431.4	-	7	1286	c.1095G>A	c.(1093-1095)aaG>aaA	p.K365K	LRRIQ3_ENST00000395089.1_Silent_p.K365K	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	365										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						CTGCATTATTCTTCAATGAAC	0.338000													22	72					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119892174	119892174	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119892174C>T	ENST00000464295.1	-	9	1522	c.1077G>A	c.(1075-1077)gaG>gaA	p.E359E	GPR156_ENST00000461057.1_Silent_p.E355E|GPR156_ENST00000315843.3_Silent_p.E359E			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	359						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		TGAGGAGCCTCTCCATGGAGC	0.527000													21	54					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92102891	92102891	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92102891G>A	ENST00000256343.3	-	17	1776	c.1620C>T	c.(1618-1620)gcC>gcT	p.A540A		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	540					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TGTGCTGTGGGGCAAGCGCAG	0.378000													18	55					0	0	1	0	0
DGKE	8526	broad.mit.edu	37	17	54925375	54925375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54925375G>A	ENST00000284061.3	+	5	1017	c.837G>A	c.(835-837)ggG>ggA	p.G279G		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	279	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					TTTGTGGAGGGGATGGGACTG	0.398000													16	77					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149878254	149878254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149878254C>T	ENST00000369146.3	-	11	2323	c.1833G>A	c.(1831-1833)ggG>ggA	p.G611G	SV2A_ENST00000369145.1_Silent_p.G611G	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	611				G -> R (in Ref. 3; BAC11645).	neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ACACGATATTCCCAGGAAGCA	0.577000													17	75					0	0	1	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153312970	153312970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153312970G>A	ENST00000368739.3	-	7	1057	c.699C>T	c.(697-699)atC>atT	p.I233I	PGLYRP4_ENST00000359650.5_Silent_p.I237I			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	237					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGTGGATAATGATGCCATACT	0.597000													25	65					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3782725	3782725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:3782725C>T	ENST00000440314.2	-	7	1031	c.558G>A	c.(556-558)ctG>ctA	p.L186L	EFCAB4B_ENST00000444507.1_Silent_p.L186L|EFCAB4B_ENST00000252322.1_Silent_p.L186L	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	186					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			CCTCCTTCTTCAGCTGCAACC	0.493000													33	69					0	0	1	0	0
PPP1R1A	5502	broad.mit.edu	37	12	54971195	54971195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54971195C>T	ENST00000547431.1	-	6	466	c.439G>A	c.(439-441)Gac>Aac	p.D147N	PDE1B_ENST00000243052.3_Intron|PDE1B_ENST00000550620.1_Intron|PDE1B_ENST00000394277.3_Intron|PDE1B_ENST00000538346.1_Intron			Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1A	21	Interaction with PPP1R15A.		G -> D (in dbSNP:rs34376731).		glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			lung(2)	2						GTTGGGTCGTCTCTGGGCTCC	0.542000													84	190					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671554	39671554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39671554C>T	ENST00000398930.1	+	4	725	c.371C>T	c.(370-372)tCc>tTc	p.S124F	KCNJ15_ENST00000398938.2_Missense_Mutation_p.S124F|KCNJ15_ENST00000398932.1_Missense_Mutation_p.S124F|KCNJ15_ENST00000398934.1_Missense_Mutation_p.S124F|KCNJ15_ENST00000328656.3_Missense_Mutation_p.S124F			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	124					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						TCCCTGGAATCCCAGACAACC	0.498000													31	101					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35700677	35700677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35700677C>T	ENST00000440995.2	+	16	2206	c.2206C>T	c.(2206-2208)Ctt>Ttt	p.L736F	SPEF2_ENST00000356031.3_Missense_Mutation_p.L741F|SPEF2_ENST00000509059.1_Missense_Mutation_p.L736F|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	741					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGAAGAAGCTCTTACAGGCTG	0.398000													20	61					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50530608	50530608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50530608G>A	ENST00000374144.3	+	3	306	c.18G>A	c.(16-18)aaG>aaA	p.K6K	C10orf71_ENST00000323868.4_Silent_p.K6K			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	6										endometrium(1)	1						AAGGAAATAAGAAGTGCACAG	0.537000													4	13					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38750845	38750845	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38750845C>T	ENST00000359357.3	+	15	1928	c.1674C>T	c.(1672-1674)tcC>tcT	p.S558S	DNAH8_ENST00000441566.1_Silent_p.S558S|DNAH8_ENST00000449981.2_Silent_p.S775S					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACAAGATCTCCTATGTGCTGG	0.403000													24	55					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47532341	47532341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47532341C>T	ENST00000300527.4	+	3	668	c.564C>T	c.(562-564)ttC>ttT	p.F188F	COL6A2_ENST00000310645.5_Silent_p.F188F|COL6A2_ENST00000357838.4_Silent_p.F188F|COL6A2_ENST00000409416.1_Silent_p.F188F|COL6A2_ENST00000460886.1_3'UTR|COL6A2_ENST00000397763.1_Silent_p.F188F	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	188	Nonhelical region.|VWFA 1.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TCCGGCTCTTCGCCGTGGCCC	0.706000													5	20					0	0	1	0	0
CYTH1	9267	broad.mit.edu	37	17	76705812	76705812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76705812G>A	ENST00000446868.3	-	2	95	c.25C>T	c.(25-27)Ccc>Tcc	p.P9S	CYTH1_ENST00000589297.1_5'UTR|CYTH1_ENST00000585509.1_5'UTR|CYTH1_ENST00000591455.1_Missense_Mutation_p.P9S|CYTH1_ENST00000361101.4_Missense_Mutation_p.P9S|CYTH1_ENST00000589296.1_Missense_Mutation_p.P9S			Q15438	CYH1_HUMAN	cytohesin 1	9					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	19						AGGTCACTGGGAACTACAAAA	0.468000													23	71					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264273	155264273	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155264273C>T	ENST00000392414.3	-	6	985	c.872_splice	c.e6+1	p.R291_splice	PKLR_ENST00000342741.4_Splice_Site_p.R322_splice	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	322					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CAAGCCTCACCTCTTCACGCC	0.577000													27	60					0	0	1	0	0
AVIL	10677	broad.mit.edu	37	12	58196037	58196037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58196037C>T	ENST00000537081.1	-	16	2035	c.2036G>A	c.(2035-2037)cGa>cAa	p.R679Q	TSFM_ENST00000543727.1_Intron|TSFM_ENST00000550559.1_Missense_Mutation_p.R218W|TSFM_ENST00000548851.1_Intron|AVIL_ENST00000257861.3_Missense_Mutation_p.R686Q			O75366	AVIL_HUMAN	advillin	686	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GTCGGGATCTCGGCCGCTGGG	0.557000													19	26					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800940	185800940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185800940G>A	ENST00000302277.6	+	4	1411	c.817G>A	c.(817-819)Gag>Aag	p.E273K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	273						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GAGTTCTGAGGAGAAAACTAA	0.393000													26	103					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72004417	72004417	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72004417G>A	ENST00000294053.3	-	17	2291	c.2118C>T	c.(2116-2118)acC>acT	p.T706T	CLPB_ENST00000340729.5_Silent_p.T647T|CLPB_ENST00000538021.1_Silent_p.T314T|CLPB_ENST00000543042.1_Silent_p.T505T|CLPB_ENST00000538039.1_Silent_p.T676T|CLPB_ENST00000437826.2_Silent_p.T661T	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	706					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						GCTGCTAGATGGTGTTGCACA	0.592000													23	35					0	0	1	0	0
TIGD2	166815	broad.mit.edu	37	4	90035004	90035004	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:90035004C>T	ENST00000317005.2	+	1	1037	c.879C>T	c.(877-879)ttC>ttT	p.F293F		NM_145715.2	NP_663761.1	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	293	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	14		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		TTTTAGATTTCCCCCCAGCAC	0.393000													35	83					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18707817	18707817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18707817C>T	ENST00000392386.3	-	5	933	c.740G>A	c.(739-741)gGg>gAg	p.G247E		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	247	Fibronectin type-III 2.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						CTCCAGGCCCCCGACGCGGCT	0.662000													4	39					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878979	24878979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24878979C>T	ENST00000382554.3	+	4	2297	c.1979C>T	c.(1978-1980)tCc>tTc	p.S660F		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	660					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCTGCAGCTTCCAAAGCACCT	0.567000													4	22					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947463	237947463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237947463G>A	ENST00000366574.2	+	90	12768	c.12451G>A	c.(12451-12453)Gaa>Aaa	p.E4151K	RYR2_ENST00000542537.1_Missense_Mutation_p.E4135K|RYR2_ENST00000360064.6_Missense_Mutation_p.E4157K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4151					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTCTATTTTGAAATCAGTGA	0.498000													60	96					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306010	54306010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54306010G>A	ENST00000545554.1	+	1	910	c.910G>A	c.(910-912)Gac>Aac	p.D304N	UNC13C_ENST00000537900.1_Missense_Mutation_p.D304N|UNC13C_ENST00000260323.11_Missense_Mutation_p.D304N			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	304					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGAAACTAGAGACATCCATGA	0.428000													42	141					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127642053	127642053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127642053C>T	ENST00000405109.1	+	2	616	c.149C>T	c.(148-150)gCt>gTt	p.A50V	KBTBD12_ENST00000407609.3_Intron|KBTBD12_ENST00000405256.1_Missense_Mutation_p.A50V			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	50	BTB.									endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						CTGGTCCTGGCTGCATTTAGC	0.393000													21	47					0	0	1	0	0
SLC39A4	55630	broad.mit.edu	37	8	145642042	145642042	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145642042C>T	ENST00000301305.3	-	1	237	c.132G>A	c.(130-132)ctG>ctA	p.L44L		NM_130849.2	NP_570901.2	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter), member 4	44						cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	14	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			ACAGGCCGCCCAGAGCCTCTT	0.677000													5	17					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72775173	72775173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:72775173C>T	ENST00000299687.5	+	8	5496	c.5496C>T	c.(5494-5496)agC>agT	p.S1832S		NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1832					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGACAGACAGCCCCTTCACCG	0.622000													45	166					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	8987935	8987935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:8987935G>A	ENST00000344836.4	-	31	3427	c.3229C>T	c.(3229-3231)Cta>Tta	p.L1077L	USP7_ENST00000381886.4_Silent_p.L1061L|USP7_ENST00000535863.1_Silent_p.L978L	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	1077					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						TCGAGCCCTAGCCAAGGCCGA	0.522000													35	117					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156812901	156812901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156812901G>A	ENST00000368195.3	-	17	3417	c.3021C>T	c.(3019-3021)tcC>tcT	p.S1007S	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	1007	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCACGGGTGTGGACTCCTCTC	0.572000													16	52					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134125848	134125848	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134125848G>A	ENST00000220616.4	+	44	7794		c.e44+1		TG_ENST00000542445.1_Splice_Site|TG_ENST00000519543.1_Splice_Site|TG_ENST00000377869.1_Splice_Site	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin						hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ATGCCACCCGGTAAGCTAAGC	0.532000													7	16					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155649647	155649647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155649647C>T	ENST00000496455.1	+	13	1989	c.1654C>T	c.(1654-1656)Cgc>Tgc	p.R552C	GMPS_ENST00000295920.7_Missense_Mutation_p.R453C	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	552					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCTTATACCTCGCATGTGTCA	0.438000			T	MLL	AML								56	171					0	0	1	0	0
LOC100505782	100505782	broad.mit.edu	37	17	39580838	39580838	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39580838G>A	ENST00000432258.1	+	0	3427																											CACTGAGACTGAAGCCTCCTC	0.572000													9	10					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114186370	114186370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114186370C>T	ENST00000369615.1	+	11	2034	c.1972C>T	c.(1972-1974)Cct>Tct	p.P658S	MAGI3_ENST00000369611.4_Missense_Mutation_p.P658S|MAGI3_ENST00000307546.9_Missense_Mutation_p.P658S|MAGI3_ENST00000369617.4_Missense_Mutation_p.P683S	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	683	PDZ 3.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTAAGGTCCTCCTTCACCAAC	0.393000													36	98					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26163834	26163834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:26163834G>A	ENST00000381655.2	+	24	2350	c.2208G>A	c.(2206-2208)ttG>ttA	p.L736L	ATP8A2_ENST00000491840.1_3'UTR|ATP8A2_ENST00000255283.8_Silent_p.L696L	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	696					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGGACTCTTTGGATGTAAGTA	0.363000													30	90					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964887	70964887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70964887C>T	ENST00000357250.6	-	23	1735	c.1577G>A	c.(1576-1578)gGa>gAa	p.G526E	COL9A1_ENST00000370499.4_Missense_Mutation_p.G283E|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000320755.7_Missense_Mutation_p.G283E	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	526	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						ACCAGGAATTCCTCTAGCACC	0.438000													55	90					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2375859	2375859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2375859C>T	ENST00000202625.2	+	3	262	c.201C>T	c.(199-201)gcC>gcT	p.A67A	TGM6_ENST00000381423.1_Silent_p.A67A|TGM6_ENST00000477505.1_Intron	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	67					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CTTCTGAGGCCCTCCACACCA	0.587000													8	27					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44685808	44685808	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44685808G>A	ENST00000454036.1	+	25	3270		c.e25-1		SLC12A5_ENST00000243964.3_Splice_Site	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5						potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCTGCCGCAGGAACCAGTCC	0.627000													10	61					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584754	1584754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1584754C>T	ENST00000381297.4	-	2	908	c.698G>A	c.(697-699)aGg>aAg	p.R233K		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	233						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACCGCGCGCCTCCGCTGCTC	0.662000			T	CRLF2	"""B-ALL, Downs associated ALL"""								11	18					0	0	1	0	0
TPSB2	64499	broad.mit.edu	37	16	1279235	1279235	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1279235C>T	ENST00000430512.2	-	0	505				TPSB2_ENST00000339687.6_RNA|TPSB2_ENST00000445910.1_RNA	NM_024164.5	NP_077078.5	P20231	TRYB2_HUMAN	tryptase beta 2 (gene/pseudogene)						proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			lung(1)|upper_aerodigestive_tract(1)	2		Hepatocellular(780;0.00369)				GCACGGCATCCCCGGGGGGGA	0.682000													6	9					0	0	1	0	0
ZPBP	11055	broad.mit.edu	37	7	50097645	50097645	+	Missense_Mutation	SNP	C	C	T	rs148913753		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50097645C>T	ENST00000046087.2	-	4	496	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	ZPBP_ENST00000419417.1_Missense_Mutation_p.E142K	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	143					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					GGTTTATATTCGAGGAAACAT	0.328000													19	64					0	0	1	0	0
IGSF3	3321	broad.mit.edu	37	1	117122373	117122373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:117122373G>A	ENST00000369486.3	-	10	3740	c.2975C>T	c.(2974-2976)tCc>tTc	p.S992F	IGSF3_ENST00000318837.6_Missense_Mutation_p.S1012F|IGSF3_ENST00000369483.1_Missense_Mutation_p.S1012F	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	992	Ig-like C2-type 8.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AGTCCTCAGGGAATACCAGGC	0.612000													15	39					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75408259	75408259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75408259G>A	ENST00000394810.2	-	4	1300	c.1151C>T	c.(1150-1152)tCt>tTt	p.S384F	SYNPO2L_ENST00000372873.4_Missense_Mutation_p.S160F|SYNPO2L_ENST00000372872.4_Missense_Mutation_p.S384F	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	384						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					CCCTCGCCCAGAGACCTCACT	0.647000													19	88					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45484726	45484726	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45484726C>T	ENST00000334940.6	+	7	697	c.563C>T	c.(562-564)tCc>tTc	p.S188F	RASSF4_ENST00000374417.2_3'UTR|RASSF4_ENST00000340258.4_Missense_Mutation_p.S179F|RASSF4_ENST00000472561.1_3'UTR			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	179	Ras-associating.				cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						GTACAGACCTCCGTGTTTACT	0.547000													14	37					0	0	1	0	0
LMOD1	25802	broad.mit.edu	37	1	201869723	201869723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201869723C>T	ENST00000367288.4	-	2	664	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K		NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	140					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CCACCAGCTTCATCTCTGTCT	0.562000													67	206					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71602146	71602146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71602146G>A	ENST00000355962.4	-	12	1399	c.1266C>T	c.(1264-1266)gtC>gtT	p.V422V	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	422					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	TCACCTCGGGGACTGTGATGA	0.512000													5	50					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155450997	155450997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155450997G>A	ENST00000461783.3	+	6	1913	c.640G>A	c.(640-642)Gcc>Acc	p.A214T	TIAM2_ENST00000318981.5_Missense_Mutation_p.A214T|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000529824.2_Missense_Mutation_p.A214T|TIAM2_ENST00000360366.4_Missense_Mutation_p.A214T|TIAM2_ENST00000456144.1_Missense_Mutation_p.A214T			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	214					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGTGCCTGAAGCCAGGAGGGG	0.637000													24	26					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7607462	7607462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7607462C>T	ENST00000221249.6	+	14	1582	c.1151C>T	c.(1150-1152)cCc>cTc	p.P384L	PNPLA6_ENST00000600737.1_Missense_Mutation_p.P423L|PNPLA6_ENST00000545201.2_Missense_Mutation_p.P384L|PNPLA6_ENST00000450331.3_Missense_Mutation_p.P384L|PNPLA6_ENST00000414982.3_Missense_Mutation_p.P432L	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	423					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						CAGGGTGGCCCCCGCTCCGAC	0.607000													9	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179631337	179631337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179631337G>A	ENST00000589042.1	-	41	9698	c.9474C>T	c.(9472-9474)gtC>gtT	p.V3158V	TTN_ENST00000342992.6_Silent_p.V3158V|TTN_ENST00000360870.5_Silent_p.V3158V|TTN_ENST00000591111.1_Silent_p.V3158V|TTN_ENST00000342175.6_Silent_p.V3112V|TTN_ENST00000359218.5_Silent_p.V3112V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V3112V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2893							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTCTCAATGACCTGTTGAT	0.368000													14	43					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116049295	116049295	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116049295C>T	ENST00000603594.1	+	12	2490	c.2169C>T	c.(2167-2169)ccC>ccT	p.P723P	VWA2_ENST00000392982.3_Intron	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	0	EGF-like 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		ATGGCAGGCCCTCAGCCTGAG	0.597000													16	38					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024624	76024624	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76024624C>T	ENST00000393004.2	-	5	1145	c.924G>A	c.(922-924)tcG>tcA	p.S308S	FILIP1_ENST00000237172.7_Silent_p.S308S|FILIP1_ENST00000370020.1_Silent_p.S209S|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	308										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GAGAAAACCTCGAAGCCTTGT	0.418000													40	60					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057714	63057714	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63057714C>T	ENST00000332793.6	+	1	79	c.77C>T	c.(76-78)cCc>cTc	p.P26L	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	26						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTTATTCTTCCCTCTCTCATG	0.458000													26	49					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36259149	36259149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36259149C>T	ENST00000394571.2	+	2	258	c.258C>T	c.(256-258)ttC>ttT	p.F86F	PNPLA1_ENST00000388715.3_5'UTR|PNPLA1_ENST00000312917.5_5'UTR	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	86	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						AGAAATCCTTCCTGGGGCCCT	0.592000													19	51					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121428052	121428052	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121428052C>T	ENST00000260197.7	+	19	2730	c.2601C>T	c.(2599-2601)ctC>ctT	p.L867L		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	867					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ACTTCCGACTCACAATCGTCA	0.527000													34	106					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6702214	6702214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6702214C>T	ENST00000245907.6	-	19	2456	c.2364G>A	c.(2362-2364)acG>acA	p.T788T		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	788					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding	p.T788T(1)		breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TCATGAGCTTCGTAGAGATTC	0.512000													14	60					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57013143	57013143	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:57013143C>T	ENST00000370706.4	+	10	2504	c.2260C>T	c.(2260-2262)Cgc>Tgc	p.R754C	RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Missense_Mutation_p.R754C|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.R754C|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	754					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ACTGTGGTTTCGCTGCAGTTT	0.413000													6	33					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111616007	111616007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:111616007G>A	ENST00000261486.5	-	3	494	c.218C>T	c.(217-219)cCt>cTt	p.P73L		NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	73	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		GGTTTTTGCAGGATCCAGCCA	0.333000													42	228					0	0	1	0	0
TMEM56	148534	broad.mit.edu	37	1	95657146	95657146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:95657146G>A	ENST00000370203.4	+	7	805	c.514G>A	c.(514-516)Gct>Act	p.A172T	RP11-57H12.6_ENST00000604534.1_Intron|RP11-57H12.3_ENST00000421762.1_RNA|RP11-57H12.3_ENST00000419846.1_RNA	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56	172	TLC.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		GTTTTCTAAAGCTATCGTTAT	0.368000													51	123					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121996	38121996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38121996G>A	ENST00000406386.3	+	7	3688	c.3433G>A	c.(3433-3435)Gag>Aag	p.E1145K	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1145					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GGCCAGCACAGAGAGCCTTGT	0.642000													45	128					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156635959	156635959	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156635959G>A	ENST00000422843.3	+	2	350	c.198G>A	c.(196-198)gtG>gtA	p.V66V	CTB-4E7.1_ENST00000519375.1_RNA	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	66	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGAGATTGTGAAAAGTGACA	0.463000			T	SYK	peripheral T-cell lymphoma								8	54					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28378638	28378638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28378638C>T	ENST00000337532.5	-	13	1361	c.1085G>A	c.(1084-1086)cGa>cAa	p.R362Q	MPP7_ENST00000445954.2_Missense_Mutation_p.R237Q|MPP7_ENST00000540098.1_Missense_Mutation_p.R362Q|MPP7_ENST00000375719.3_Missense_Mutation_p.R362Q|MPP7_ENST00000375732.1_Missense_Mutation_p.R362Q	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	362					establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						ATTAGTTTGTCGCCGATACGG	0.388000													73	215					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111748007	111748007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111748007G>A	ENST00000261726.6	+	15	1575	c.1421G>A	c.(1420-1422)cGg>cAg	p.R474Q		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	474	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R474Q(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GACGGCACTCGGACTTTCTCG	0.697000													4	12					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170406	58170406	+	Silent	SNP	C	C	T	rs141530938		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58170406C>T	ENST00000309403.2	-	1	476	c.477G>A	c.(475-477)ggG>ggA	p.G159G		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G159G(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TAAATGTGTCCCCAGTGTGGA	0.453000													26	134					0	0	1	0	0
TATDN2	9797	broad.mit.edu	37	3	10291286	10291286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10291286C>T	ENST00000287652.4	+	2	1453	c.402C>T	c.(400-402)gcC>gcT	p.A134A	RP11-438J1.1_ENST00000450534.1_Silent_p.A77A|TATDN2_ENST00000448281.2_Silent_p.A134A	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	134						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						AGGAGGAAGCCTGCAGCCTTA	0.562000													13	52					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101839977	101839977	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101839977C>T	ENST00000360264.3	+	15	1339	c.1319C>T	c.(1318-1320)cCc>cTc	p.P440L	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292535.7_Missense_Mutation_p.P429L|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000556210.1_Intron|CUX1_ENST00000550008.2_Missense_Mutation_p.P429L|CUX1_ENST00000549414.2_Missense_Mutation_p.P429L|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Intron	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	429					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TTGCCGGCCCCCCCTCCTTCT	0.567000													34	87					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107019950	107019950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:107019950G>A	ENST00000369063.3	-	9	1577	c.1112C>T	c.(1111-1113)cCt>cTt	p.P371L	RTN4IP1_ENST00000498091.1_5'UTR|RTN4IP1_ENST00000539449.1_3'UTR	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	371						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		TTTAGAAAAAGGAAAGGTTTG	0.378000													24	46					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31474869	31474869	+	Silent	SNP	C	C	T	rs143678527	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31474869C>T	ENST00000252229.6	+	4	763	c.684C>T	c.(682-684)tcC>tcT	p.S228S	MICB_ENST00000399150.3_Silent_p.S185S|MICB_ENST00000538442.1_Silent_p.S196S	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	228	Ig-like C1-type.				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						GCAGGGCTTCCAGCTTCTATC	0.577000													15	51					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62774377	62774377	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62774377G>A	ENST00000400873.3	-	0	1019					NR_026899.1																						CGCGGCTGGGGAGAGGGAGCT	0.612000													3	9					0	0	1	0	0
EMC2	9694	broad.mit.edu	37	8	109498750	109498750	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:109498750C>T	ENST00000220853.3	+	11	852	c.817C>T	c.(817-819)Cga>Tga	p.R273*	EMC2_ENST00000520294.1_3'UTR	NM_014673.3	NP_055488.1			ER membrane protein complex subunit 2									p.R273*(1)									GTTTGCAGGTCGAAGTAAGAA	0.333000													14	36					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814347	242814347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242814347G>A	ENST00000343216.3	+	2	668	c.640G>A	c.(640-642)Gac>Aac	p.D214N		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	214						integral to membrane											TACCAGCAATGACCAGGTGCC	0.667000													19	31					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80419559	80419559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:80419559C>T	ENST00000265080.4	+	16	2636	c.2569C>T	c.(2569-2571)Cgg>Tgg	p.R857W		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	857					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CTCAACTCCTCGGCACCTCCG	0.532000													17	48					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2890665	2890665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:2890665C>T	ENST00000380698.4	-	7	952	c.863G>A	c.(862-864)gGa>gAa	p.G288E		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	288					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				ATCAACAATTCCCAAATGCCG	0.463000													37	111					0	0	1	0	0
DUSP10	11221	broad.mit.edu	37	1	221912437	221912437	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:221912437G>A	ENST00000366899.3	-	2	888	c.650C>T	c.(649-651)tCc>tTc	p.S217F	DUSP10_ENST00000323825.3_Intron	NM_007207.4	NP_009138.1	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10	217	Rhodanese.				inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			NS(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(131;0.0103)		TTCCCTACAGGAAATCAAGTC	0.468000													17	71					0	0	1	0	0
NRN1L	123904	broad.mit.edu	37	16	67920138	67920138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67920138C>T	ENST00000576147.1	+	2	548	c.254C>T	c.(253-255)cCt>cTt	p.P85L	NRN1L_ENST00000339176.3_Silent_p.A158A|CTC-479C5.10_ENST00000572067.1_RNA			Q496H8	NRN1L_HUMAN	neuritin 1-like	0						anchored to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		TGGCTCTGGCCTACCTCCTGA	0.682000													5	16					0	0	1	0	0
TRBV30	28557	broad.mit.edu	37	7	142510528	142510528	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142510528C>T	ENST00000417977.2	-	0	189																											GCACCAGGGTCGCTGGCCATT	0.577000													4	13					0	0	1	0	0
CCDC146	57639	broad.mit.edu	37	7	76908153	76908153	+	Missense_Mutation	SNP	C	C	T	rs144226591	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76908153C>T	ENST00000285871.4	+	12	1652	c.1525C>T	c.(1525-1527)Cgg>Tgg	p.R509W	CCDC146_ENST00000431197.1_Missense_Mutation_p.R223W|CCDC146_ENST00000415740.2_3'UTR	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	509										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TGAAATTTATCGGAGGTAAAG	0.303000													5	31					0	0	1	0	0
TRAV26-2	28656	broad.mit.edu	37	14	22671253	22671253	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22671253C>T	ENST00000390460.1	+	0	318																											ACTACTGCATCCTGAGAGACC	0.527000													4	35					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185146729	185146729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185146729C>T	ENST00000265026.3	+	2	694	c.360C>T	c.(358-360)ttC>ttT	p.F120F	MAP3K13_ENST00000535426.1_Intron|MAP3K13_ENST00000446828.1_Intron|MAP3K13_ENST00000443863.1_Intron|MAP3K13_ENST00000424227.1_Silent_p.F120F	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	120					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGATTCAGTTCAGCAGGTCAG	0.488000													22	63					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45711070	45711070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45711070C>T	ENST00000291582.5	+	8	1099	c.972C>T	c.(970-972)tcC>tcT	p.S324S	AIRE_ENST00000329347.4_Silent_p.S117S|AIRE_ENST00000355347.4_Silent_p.S117S	NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	324					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		CCTGCCTGTCCCCTCCGCTCC	0.682000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				10	30					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46365631	46365631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:46365631G>A	ENST00000359930.4	-	3	1082	c.231C>T	c.(229-231)caC>caT	p.H77H	SULF2_ENST00000478766.1_5'UTR|SULF2_ENST00000484875.1_Silent_p.H77H|SULF2_ENST00000361612.4_Silent_p.H77H|SULF2_ENST00000467815.1_Silent_p.H77H	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	77					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CGTTGATGAAGTGCGCCCCGC	0.597000													7	75					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67039548	67039548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:67039548G>A	ENST00000315962.4	+	1	418	c.45G>A	c.(43-45)caG>caA	p.Q15Q	TRIM55_ENST00000350034.4_Silent_p.Q15Q|TRIM55_ENST00000353317.5_Silent_p.Q15Q|TRIM55_ENST00000276573.7_Silent_p.Q15Q	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	15						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			AAGAGCAGCAGACCATGGATA	0.502000													26	103					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88764104	88764104	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88764104C>T	ENST00000444431.1	+	0	2646				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GATACATCATCATATCACGGA	0.373000													100	235					0	0	1	0	0
CXCR2	3579	broad.mit.edu	37	2	219000422	219000422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219000422G>A	ENST00000318507.2	+	3	1325	c.898G>A	c.(898-900)Gag>Aag	p.E300K		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	300					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						GGATGCCACCGAGATTCTGGG	0.567000													31	104					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97150338	97150338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:97150338C>T	ENST00000524981.3	+	24	3296	c.3296C>T	c.(3295-3297)tCa>tTa	p.S1099L				Q6ZTY8	CL063_HUMAN		1073										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GATCAAAACTCAGGGTAAAAA	0.383000													6	18					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284537	52284537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52284537C>T	ENST00000301190.6	+	5	1034	c.807C>T	c.(805-807)ctC>ctT	p.L269L	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Silent_p.L144L|ANKRD33_ENST00000538991.1_Silent_p.L75L	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	144										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		TGTCCGGGCTCGTggcccagg	0.677000													6	18					0	0	1	0	0
UBE3D	90025	broad.mit.edu	37	6	83728787	83728787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:83728787G>A	ENST00000369747.3	-	8	1037	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_198920.1	NP_944602.1	Q7Z6J8	UB2CB_HUMAN	ubiquitin protein ligase E3D	305						cytoplasm	ligase activity										CCAACAAGGGGAATTTTTTGA	0.378000													29	38					0	0	1	0	0
PRKG2	5593	broad.mit.edu	37	4	82027083	82027083	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:82027083G>A	ENST00000395578.1	-	16	2063	c.1947C>T	c.(1945-1947)ccC>ccT	p.P649P	PRKG2_ENST00000418486.2_Silent_p.P620P|PRKG2_ENST00000264399.1_Silent_p.P649P|PRKG2_ENST00000509169.1_5'UTR|PRKG2_ENST00000545647.1_Silent_p.P229P			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	649	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						CCCCAGAAAAGGGTGGGCTAG	0.398000													22	53					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55177268	55177268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55177268C>T	ENST00000391736.1	+	9	1075	c.760C>T	c.(760-762)Ctg>Ttg	p.L254L	LILRB4_ENST00000270452.2_Silent_p.L254L|LILRB4_ENST00000391734.3_Silent_p.L254L|LILRB4_ENST00000391733.3_Silent_p.L254L|LILRB4_ENST00000430952.2_Silent_p.L254L	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	254						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CGCCCAAGGTCTGAGAAGGCA	0.537000													4	10					0	0	1	0	0
MTERFD2	130916	broad.mit.edu	37	2	242039285	242039285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242039285G>A	ENST00000391980.2	-	2	104	c.46C>T	c.(46-48)Ccc>Tcc	p.P16S	MTERFD2_ENST00000495694.1_Missense_Mutation_p.P16S|MTERFD2_ENST00000407095.3_Missense_Mutation_p.P16S|MTERFD2_ENST00000406593.1_Intron	NM_182501.3	NP_872307.2	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	16										endometrium(3)|large_intestine(6)|lung(5)|ovary(1)|skin(2)|urinary_tract(3)	20		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		CAGGTGAGGGGGATCAGGCGG	0.498000													14	33					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42992800	42992800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42992800C>T	ENST00000253408.5	-	1	120	c.55G>A	c.(55-57)Gag>Aag	p.E19K	GFAP_ENST00000435360.2_Missense_Mutation_p.E19K|GFAP_ENST00000586793.1_Missense_Mutation_p.E19K|GFAP_ENST00000591327.1_5'UTR|GFAP_ENST00000588735.1_Missense_Mutation_p.E19K	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	19	Head.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				ACCATCATCTCCCCTGAGGAG	0.667000													6	9					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113285641	113285641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113285641G>A	ENST00000389385.4	+	5	721	c.224G>A	c.(223-225)cGa>cAa	p.R75Q	RPH3A_ENST00000420983.2_Missense_Mutation_p.R75Q|RPH3A_ENST00000415485.3_Missense_Mutation_p.R75Q|RPH3A_ENST00000551052.1_Missense_Mutation_p.R71Q|RPH3A_ENST00000543106.2_Missense_Mutation_p.R75Q|RPH3A_ENST00000447659.2_Intron|RPH3A_ENST00000548866.1_Intron	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	75	RabBD.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding	p.R71Q(1)		breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GAGCAGGAGCGAATCGGGTGA	0.562000													10	23					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108138014	108138014	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108138014C>T	ENST00000278616.4	+	17	2968	c.2583C>T	c.(2581-2583)taC>taT	p.Y861Y	ATM_ENST00000452508.2_Silent_p.Y861Y	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	861					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTAACGATTACCCTGATAGTA	0.368000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			22	66					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55268104	55268104	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55268104C>T	ENST00000275493.2	+	24	3121	c.2944C>T	c.(2944-2946)Cag>Tag	p.Q982*	EGFR_ENST00000454757.2_Nonsense_Mutation_p.Q929*|EGFR_ENST00000455089.1_Nonsense_Mutation_p.Q937*|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	982					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCTTGTCATTCAGGTACAAAT	0.522000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			19	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179542591	179542591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179542591C>T	ENST00000589042.1	-	146	34272	c.34048G>A	c.(34048-34050)Gaa>Aaa	p.E11350K	TTN_ENST00000342992.6_Missense_Mutation_p.E10106K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E11033K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11033	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATAGAACTTCCTCTTCCTGA	0.393000													49	88					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2716282	2716282	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2716282C>T	ENST00000399655.1	+	26	3607	c.3342C>T	c.(3340-3342)ttC>ttT	p.F1114F	CACNA1C_ENST00000347598.4_Silent_p.F1134F|CACNA1C_ENST00000399591.1_Silent_p.F1114F|CACNA1C_ENST00000480911.1_Silent_p.F1114F|CACNA1C_ENST00000344100.3_Silent_p.F1114F|CACNA1C_ENST00000399597.1_Silent_p.F1114F|CACNA1C_ENST00000335762.5_Silent_p.F1139F|CACNA1C_ENST00000399595.1_Silent_p.F1114F|CACNA1C_ENST00000399603.1_Silent_p.F1114F|CACNA1C_ENST00000399617.1_Silent_p.F1114F|CACNA1C_ENST00000399606.1_Silent_p.F1134F|CACNA1C_ENST00000399621.1_Silent_p.F1114F|CACNA1C_ENST00000399601.1_Silent_p.F1114F|CACNA1C-AS3_ENST00000543559.1_RNA|CACNA1C_ENST00000399638.1_Silent_p.F1114F|CACNA1C_ENST00000399649.1_Silent_p.F1114F|CACNA1C_ENST00000399644.1_Silent_p.F1114F|CACNA1C_ENST00000399629.1_Silent_p.F1114F|CACNA1C_ENST00000327702.7_Silent_p.F1114F|CACNA1C_ENST00000399634.1_Silent_p.F1114F|CACNA1C_ENST00000399637.1_Silent_p.F1114F|CACNA1C_ENST00000406454.3_Silent_p.F1114F|CACNA1C_ENST00000402845.3_Silent_p.F1114F|CACNA1C_ENST00000399641.1_Silent_p.F1114F	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1134	Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCTCCACCTTCGAAGGGTGGC	0.537000													6	18					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147381070	147381070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:147381070G>A	ENST00000240986.4	+	2	1041	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	GJA8_ENST00000369235.1_Missense_Mutation_p.E330K	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	330					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					GGGGGCACAAGAAGTGGAGGG	0.617000													3	17					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46746655	46746655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:46746655G>A	ENST00000394809.4	-	10	2134	c.2019C>T	c.(2017-2019)ttC>ttT	p.F673F	MYLK3_ENST00000536476.1_Silent_p.F332F	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	673	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity	p.F673F(1)|p.F752F(1)		central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CAGGAGTGCCGAAGTTCACCT	0.547000													15	45					0	0	1	0	0
MFSD11	79157	broad.mit.edu	37	17	74772585	74772585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74772585G>A	ENST00000588460.1	+	12	3189	c.1147G>A	c.(1147-1149)Gac>Aac	p.D383N	MFSD11_ENST00000336509.4_Missense_Mutation_p.D383N|MFSD11_ENST00000355954.3_Missense_Mutation_p.D331N|MFSD11_ENST00000590070.1_3'UTR|MFSD11_ENST00000590514.1_Missense_Mutation_p.D383N|MFSD11_ENST00000586622.1_Missense_Mutation_p.D383N|MFSD11_ENST00000593181.1_Missense_Mutation_p.D331N	NM_001242534.1	NP_001229463.1	O43934	MFS11_HUMAN	major facilitator superfamily domain containing 11	383						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)	17						GTATTCTGAAGACAGCGCCCC	0.453000													48	169					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36122792	36122792	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:36122792G>A	ENST00000378660.1	+	8	1217	c.1029G>A	c.(1027-1029)tgG>tgA	p.W343*	CHDC2_ENST00000313548.4_Nonsense_Mutation_p.W343*					calponin homology domain containing 2																		ATGTGATATGGAAAAACTGTC	0.328000													7	34					0	0	1	0	0
NDST2	8509	broad.mit.edu	37	10	75567892	75567892	+	Silent	SNP	G	G	A	rs138811491		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75567892G>A	ENST00000309979.6	-	3	811	c.255C>T	c.(253-255)ccC>ccT	p.P85P	NDST2_ENST00000299641.4_5'UTR			P52849	NDST2_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	85	Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30	Prostate(51;0.0112)					CAAGGACCACGGGTTCAGTTC	0.602000													20	34					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089917	9089917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9089917G>A	ENST00000397910.4	-	1	2101	c.1898C>T	c.(1897-1899)tCa>tTa	p.S633L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	633	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCTCAGATGATGCTGTGGC	0.577000													20	80					0	0	1	0	0
PLIN3	10226	broad.mit.edu	37	19	4839365	4839365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4839365G>A	ENST00000221957.4	-	8	1320	c.1144C>T	c.(1144-1146)Ctg>Ttg	p.L382L	PLIN3_ENST00000592528.1_Silent_p.L370L|PLIN3_ENST00000585479.1_Silent_p.L381L	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	382					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	CTGCTGGACAGGTCCTGGAAG	0.647000													13	57					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182885	140182885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140182885C>T	ENST00000522353.2	+	1	2103	c.2103C>T	c.(2101-2103)atC>atT	p.I701I	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Silent_p.I701I|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACTTGATCGTCGCCATCT	0.662000													13	151					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40702463	40702463	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40702463C>T	ENST00000372771.4	+	8	2116	c.2089C>T	c.(2089-2091)Caa>Taa	p.Q697*		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	697					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AGCTGAACACCAAAATAATGA	0.388000													32	95					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227967505	227967505	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227967505C>T	ENST00000396625.3	-	15	1137	c.930_splice	c.e15+1	p.R310_splice	COL4A4_ENST00000329662.7_Splice_Site_p.R310_splice	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	310	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGATGCTTACCCGAGGCCCTG	0.398000													41	100					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70672748	70672748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70672748G>A	ENST00000322773.4	+	11	1114	c.1012G>A	c.(1012-1014)Gaa>Aaa	p.E338K		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	338	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CAGCAAAGGAGAAACTGGTGA	0.284000													17	42					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157931196	157931196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157931196G>A	ENST00000389413.3	-	7	1025	c.922C>T	c.(922-924)Cat>Tat	p.H308Y	PTPRN2_ENST00000409483.1_Missense_Mutation_p.H270Y|PTPRN2_ENST00000404321.2_Missense_Mutation_p.H331Y|PTPRN2_ENST00000389416.4_Missense_Mutation_p.H291Y|PTPRN2_ENST00000389418.4_Missense_Mutation_p.H308Y	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	308						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGGAGGGTATGAATCCGTGCT	0.617000													21	61					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50472794	50472794	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50472794C>A	ENST00000266182.6	-	9	1018	c.1019G>T	c.(1018-1020)cGg>cTg	p.R340L	TTLL8_ENST00000440475.1_Missense_Mutation_p.R324L					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		ACCTCGGCCCCGGGACTTGGC	0.602000													5	41					0.00198382	0.00198538	1	1	0
TLR5	7100	broad.mit.edu	37	1	223285897	223285897	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:223285897G>A	ENST00000540964.1	-	4	938	c.477C>T	c.(475-477)agC>agT	p.S159S	TLR5_ENST00000342210.6_Silent_p.S159S			O60602	TLR5_HUMAN	toll-like receptor 5	159					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		GAAGGTAAAGGCTACGAATCT	0.378000													25	103					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57871033	57871033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57871033C>T	ENST00000393797.2	-	8	1181	c.989G>A	c.(988-990)gGg>gAg	p.G330E	ARHGAP9_ENST00000550288.1_Missense_Mutation_p.G338E|ARHGAP9_ENST00000550454.1_5'UTR|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.G259E|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.G75E|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.G259E|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.G259E			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	259	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			GGTCTGTGTCCCCTCCATGGA	0.542000													8	50					0	0	1	0	0
NKX2-1	7080	broad.mit.edu	37	14	36987098	36987098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:36987098G>A	ENST00000518149.1	-	3	1106	c.501C>T	c.(499-501)ctC>ctT	p.L167L	NKX2-1_ENST00000498187.2_Silent_p.L167L|RP11-896J10.3_ENST00000521945.1_RNA|NKX2-1_ENST00000354822.5_Silent_p.L197L|NKX2-1_ENST00000522719.2_Silent_p.L167L			P43699	NKX21_HUMAN	NK2 homeobox 1	167					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		CCTGCGAGAAGAGCACCCGGC	0.672000			A		NSCLC								7	15					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188460	7188460	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7188460G>A	ENST00000542285.1	-	11	1487	c.1338C>T	c.(1336-1338)ctC>ctT	p.L446L				P00736	C1R_HUMAN	complement component 1, r subcomponent	498	Sushi 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGGCAGCTGTGAGGATCCAGC	0.607000													5	39					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55087397	55087397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55087397G>A	ENST00000251377.3	+	7	1209	c.1076G>A	c.(1075-1077)gGg>gAg	p.G359E	LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.G359E|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391737.1_Missense_Mutation_p.G347E|LILRA2_ENST00000391738.3_Missense_Mutation_p.G359E					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		ACCAAGGAGGGGGCAGGCCAT	0.617000													32	62					0	0	1	0	0
LRCH4	4034	broad.mit.edu	37	7	100176357	100176357	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100176357G>A	ENST00000310300.6	-	5	703	c.651C>T	c.(649-651)tcC>tcT	p.S217S	LRCH4_ENST00000497245.1_5'UTR	NM_002319.3	NP_002310.2	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 4	217					nervous system development	PML body	protein binding			NS(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	23	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGGGATTCGGGAGACGCGGT	0.622000													7	68					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367179	107367179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107367179G>A	ENST00000542196.1	-	1	772	c.730C>T	c.(730-732)Cat>Tat	p.H244Y		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ACAGTCAGATGGGCTGAACAG	0.413000													33	61					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66423280	66423280	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66423280G>A	ENST00000341529.3	+	5	784	c.636G>A	c.(634-636)acG>acA	p.T212T	CDH5_ENST00000563425.2_Silent_p.T212T	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	212	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		TCACAATAACGAAAAGCTTGG	0.567000													26	65					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118957062	118957062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118957062C>T	ENST00000334549.1	+	1	63	c.63C>T	c.(61-63)ttC>ttT	p.F21F		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	21						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		GAAAGCTCTTCCCTGGCCTCT	0.632000													24	48					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659603	24659603	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24659603C>T	ENST00000414583.2	+	0	3128					NR_003714.1																						CGAAGGCTGCCTTCAGTGCCT	0.652000													3	10					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10602081	10602081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10602081C>T	ENST00000547195.1	-	19	2643	c.2143G>A	c.(2143-2145)Gaa>Aaa	p.E715K	LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000541483.1_Missense_Mutation_p.E600K|MRVI1_ENST00000421747.1_Missense_Mutation_p.E797K|MRVI1_ENST00000423302.2_Missense_Mutation_p.E806K|MRVI1_ENST00000436272.1_Missense_Mutation_p.E779K|MRVI1_ENST00000534266.2_Missense_Mutation_p.E491K|MRVI1-AS1_ENST00000529979.1_RNA|MRVI1_ENST00000424001.1_Missense_Mutation_p.E491K|MRVI1_ENST00000531107.1_Missense_Mutation_p.E798K|MRVI1_ENST00000527509.2_Missense_Mutation_p.E715K|MRVI1_ENST00000558540.1_Missense_Mutation_p.E491K|MRVI1_ENST00000552103.1_Missense_Mutation_p.E715K|MRVI1-AS1_ENST00000529829.1_RNA|MRVI1_ENST00000545852.1_Missense_Mutation_p.E491K	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	779					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTCTGTTCTTCCTCCTCCTCC	0.493000													72	184					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674013	167674013	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167674013G>A	ENST00000519204.1	+	26	5824	c.5706G>A	c.(5704-5706)ggG>ggA	p.G1902G	TENM2_ENST00000545108.1_Silent_p.G2022G|TENM2_ENST00000518659.1_Silent_p.G2023G|TENM2_ENST00000520394.1_Silent_p.G1784G|TENM2_ENST00000403607.2_Silent_p.G1847G					teneurin transmembrane protein 2																		ACAAGTATGGGAAACTCTCCA	0.507000													35	85					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756783	71756783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71756783G>A	ENST00000318442.5	-	2	1031	c.541C>T	c.(541-543)Cac>Tac	p.H181Y		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		AGGCCCGGGTGGACTTTGGGG	0.662000													46	118					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100675256	100675256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100675256C>T	ENST00000306151.4	+	3	623	c.559C>T	c.(559-561)Cct>Tct	p.P187S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	187	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TATGAGCACACCTCTGACCAC	0.428000													57	277					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140201489	140201489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140201489C>T	ENST00000529859.1	+	1	129	c.129C>T	c.(127-129)ttC>ttT	p.F43F	PCDHA5_ENST00000529619.1_Silent_p.F43F|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000378126.3_Silent_p.F43F|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGAACCTTCGTTGGCCGCA	0.667000													28	127					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58232411	58232411	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58232411T>A	ENST00000317398.6	-	4	1138	c.1043A>T	c.(1042-1044)aAa>aTa	p.K348I	ZNF671_ENST00000335820.3_Missense_Mutation_p.K250I|AC003006.7_ENST00000599221.1_Intron	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCTAAAGAATTTCCCACATTC	0.448000													9	89					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43318761	43318761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43318761G>A	ENST00000331495.3	+	14	1681	c.1345G>A	c.(1345-1347)Gaa>Aaa	p.E449K	FMNL1_ENST00000587489.1_Missense_Mutation_p.E27K|CTD-2020K17.3_ENST00000587534.1_RNA|FMNL1_ENST00000328118.3_Missense_Mutation_p.E449K	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	449	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						GCGCTTCAGCGAATCGACCGC	0.687000													3	4					0	0	1	0	0
FEZF2	55079	broad.mit.edu	37	3	62358297	62358297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:62358297C>T	ENST00000283268.3	-	2	541	c.247G>A	c.(247-249)Gtg>Atg	p.V83M	FEZF2_ENST00000475839.1_Missense_Mutation_p.V83M|FEZF2_ENST00000486811.1_Missense_Mutation_p.V83M	NM_018008.3	NP_060478.3	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	83					transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|lung(8)|skin(1)	20		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		TTTGACGGCACCTCGTAGCCT	0.706000													18	46					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120817749	120817749	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:120817749G>A	ENST00000369144.3	-	12	1823	c.1696C>T	c.(1696-1698)Cag>Tag	p.Q566*	EIF3A_ENST00000541549.1_Nonsense_Mutation_p.Q532*|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	566					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AGGATCCGCTGGTGCTCTTTT	0.433000													7	20					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55839341	55839341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:55839341G>A	ENST00000302000.6	-	3	234	c.140C>T	c.(139-141)cCt>cTt	p.P47L	PYGO1_ENST00000563719.1_Missense_Mutation_p.P47L	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	47	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		AGGGAAAGAAGGTCCCTGAAA	0.363000													10	60					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233231504	233231504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233231504G>A	ENST00000258229.8	-	22	4177	c.3943C>T	c.(3943-3945)Cct>Tct	p.P1315S		NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1315						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGGATACGAGGAATGGCAAAG	0.448000													6	11					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38941495	38941495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38941495G>A	ENST00000302328.3	-	13	2110	c.1912C>T	c.(1912-1914)Cgc>Tgc	p.R638C	SCN11A_ENST00000456224.3_Missense_Mutation_p.R638C|SCN11A_ENST00000444237.2_Missense_Mutation_p.R638C|SCN11A_ENST00000450244.1_Missense_Mutation_p.R638C	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	638					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CAGCCTCGGCGAAAGTAGTGG	0.423000													14	51					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30134964	30134964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30134964G>A	ENST00000376694.4	+	2	862	c.393G>A	c.(391-393)agG>agA	p.R131R	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	131					mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						ATCGTCTCAGGAGTCGACTGG	0.468000													16	70					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20492183	20492183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20492183G>A	ENST00000573854.1	+	12	1563	c.1449G>A	c.(1447-1449)atG>atA	p.M483I	ACSM2A_ENST00000417235.2_Missense_Mutation_p.M404I|ACSM2A_ENST00000536134.1_Missense_Mutation_p.M255I|ACSM2A_ENST00000396104.2_Missense_Mutation_p.M483I|ACSM2A_ENST00000219054.6_Missense_Mutation_p.M483I|ACSM2A_ENST00000575690.1_Missense_Mutation_p.M483I|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	483					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						ATGCACTGATGGAGCACCCTG	0.567000													27	53					0	0	1	0	0
HTATIP2	10553	broad.mit.edu	37	11	20404709	20404709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20404709C>T	ENST00000451739.2	+	5	1128	c.687C>T	c.(685-687)gcC>gcT	p.A229A	HTATIP2_ENST00000443524.2_Silent_p.A229A|HTATIP2_ENST00000421577.2_Silent_p.A229A|HTATIP2_ENST00000531058.1_Silent_p.A183A|HTATIP2_ENST00000419348.2_Silent_p.A263A	NM_001098522.1	NP_001091992.1	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa	229					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity			large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						AGAACAAGGCCATCCATGACC	0.493000													7	25					0	0	1	0	0
HOXB4	3214	broad.mit.edu	37	17	46654296	46654296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46654296G>A	ENST00000332503.5	-	2	2335	c.544C>T	c.(544-546)Cac>Tac	p.H182Y	HOXB3_ENST00000489475.1_Intron|HOXB3_ENST00000465120.3_Intron|HOXB3_ENST00000552000.2_Intron|HOXB3_ENST00000498678.1_Intron|HOXB3_ENST00000476342.1_Intron|HOXB3_ENST00000472863.1_Intron|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Intron	NM_024015.4	NP_076920.1	P17483	HXB4_HUMAN	homeobox B4	182						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	9						CGGTTGTAGTGAAATTCCTTC	0.632000													60	58					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23020050	23020050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23020050G>A	ENST00000327968.5	+	1	1964	c.1876G>A	c.(1876-1878)Gag>Aag	p.E626K	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	626						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						AAGACGCAAGGAGTTTTATTT	0.363000													15	13					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5247968	5247968	+	Missense_Mutation	SNP	G	G	A	rs33930476		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5247968G>A	ENST00000335295.3	-	2	329	c.154C>T	c.(154-156)Cct>Tct	p.P52S		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	52			P -> R (in Willamette; O(2) affinity up; unstable).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	ACAGCATCAGGAGTGGACAGA	0.537000									Sickle Cell Trait				37	115					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	86996206	86996206	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:86996206G>A	ENST00000398399.2	-	4	1312	c.949C>T	c.(949-951)Caa>Taa	p.Q317*		NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CTCTTGTCTTGATGCTGTAGA	0.378000													10	92					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17507464	17507464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17507464G>A	ENST00000381869.3	-	12	3703	c.3230C>T	c.(3229-3231)cCt>cTt	p.P1077L	MTUS1_ENST00000262102.6_Missense_Mutation_p.P1131L|MTUS1_ENST00000518713.1_5'UTR|MTUS1_ENST00000297488.6_Missense_Mutation_p.P297L|MTUS1_ENST00000381861.3_Missense_Mutation_p.P378L|MTUS1_ENST00000400046.1_Missense_Mutation_p.P203L|MTUS1_ENST00000519263.1_Missense_Mutation_p.P1077L|MTUS1_ENST00000544260.1_Missense_Mutation_p.P276L	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	1131						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		CATGATCTGAGGATTTTTCTG	0.353000													34	84					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675169	81675169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81675169C>T	ENST00000550584.2	-	26	3374	c.3079G>A	c.(3079-3081)Gaa>Aaa	p.E1027K	RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000549396.1_Missense_Mutation_p.E1027K|PPFIA2_ENST00000541570.2_Missense_Mutation_p.E563K|PPFIA2_ENST00000548586.1_Missense_Mutation_p.E1021K|PPFIA2_ENST00000552948.1_Missense_Mutation_p.E1006K|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Missense_Mutation_p.E1012K|PPFIA2_ENST00000550359.2_Missense_Mutation_p.E874K|PPFIA2_ENST00000407050.4_Missense_Mutation_p.E926K|PPFIA2_ENST00000333447.7_Missense_Mutation_p.E1012K|PPFIA2_ENST00000443686.3_Missense_Mutation_p.E922K|PPFIA2_ENST00000541017.1_Missense_Mutation_p.E213K	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	926								p.E1027K(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GGAAGCCATTCATTTCCAATC	0.393000													29	81					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31317955	31317955	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31317955G>A	ENST00000265071.2	+	11	2071	c.1806G>A	c.(1804-1806)gcG>gcA	p.A602A	CDH6_ENST00000514738.1_Silent_p.A547A	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	602	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CCTGCCATGCGGAGGCGCTCA	0.572000													19	48					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19786502	19786502	+	Silent	SNP	C	C	T	rs144667976		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:19786502C>T	ENST00000341998.2	-	1	424	c.363G>A	c.(361-363)ccG>ccA	p.P121P	SLC24A2_ENST00000286344.3_Silent_p.P121P	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	121					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		AGATGTCTTTCGGGTAGTCTC	0.428000													9	92					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646505	57646505	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57646505G>A	ENST00000269834.1	-	5	1585	c.1200C>T	c.(1198-1200)ttC>ttT	p.F400F		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTTCTGAAAGAAGGCTTTTC	0.378000													69	170					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652734	121652734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121652734C>T	ENST00000393386.2	+	12	4045	c.3634C>T	c.(3634-3636)Ccc>Tcc	p.P1212S	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1212					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GGTTGAAACCCCCAAAGTTGA	0.388000													56	172					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18770674	18770674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18770674C>T	ENST00000380548.4	+	17	2631	c.2292C>T	c.(2290-2292)ttC>ttT	p.F764F		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	764						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		ATGGCAGCTTCCTGGAGCTTC	0.527000													6	25					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924844	188924844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:188924844C>T	ENST00000326866.4	+	4	1291	c.883C>T	c.(883-885)Cac>Tac	p.H295Y	ZFP42_ENST00000509524.1_Missense_Mutation_p.H295Y	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	295					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		CCTGAAAGCCCACATCCTAAC	0.463000													10	42					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087344	9087344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9087344G>A	ENST00000397910.4	-	1	4674	c.4471C>T	c.(4471-4473)Cct>Tct	p.P1491S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1491	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGACATAGGTGGAAAAATA	0.428000													18	203					0	0	1	0	0
STMN3	50861	broad.mit.edu	37	20	62275220	62275220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62275220G>A	ENST00000370053.1	-	3	261	c.180C>T	c.(178-180)tcC>tcT	p.S60S	STMN3_ENST00000540534.1_Silent_p.S49S	NM_001276310.1|NM_015894.2	NP_001263239.1|NP_056978.2	Q9NZ72	STMN3_HUMAN	stathmin-like 3	60					cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)	8	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			GGTCAGAAGGGGACTTGAGGA	0.617000													41	100					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74154189	74154189	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74154189G>A	ENST00000443185.2	-	3	1139	c.822C>T	c.(820-822)ttC>ttT	p.F274F	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		AGCCGTGGTCGAAGGAGCCCC	0.647000													14	31					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34506728	34506728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34506728C>T	ENST00000242317.4	+	13	1338	c.1167C>T	c.(1165-1167)ctC>ctT	p.L389L		NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	389					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		TCATGTGTCTCGACATCCACG	0.577000									Kartagener syndrome				27	47					0	0	1	0	0
IGLV2-33	28811	broad.mit.edu	37	22	22930884	22930884	+	RNA	SNP	C	C	T	rs112677281		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22930884C>T	ENST00000390302.2	+	0	137																											GACTCAGCCTCCTTTTGTGTC	0.567000													98	218					0	0	1	0	0
AAAS	8086	broad.mit.edu	37	12	53702957	53702957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53702957G>A	ENST00000209873.4	-	9	1084	c.919C>T	c.(919-921)Cct>Tct	p.P307S	AAAS_ENST00000394384.3_Missense_Mutation_p.P274S|AAAS_ENST00000550286.1_Missense_Mutation_p.P183S	NM_015665.5	NP_056480.1	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency, alacrimia	307					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	20						ACAGCTGAAGGAGTGGTAGCC	0.582000													76	159					0	0	1	0	0
TNRC6C	57690	broad.mit.edu	37	17	76046247	76046247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76046247C>T	ENST00000335749.4	+	3	1673	c.1104C>T	c.(1102-1104)gtC>gtT	p.V368V	TNRC6C_ENST00000588847.1_Silent_p.V368V|TNRC6C_ENST00000588061.1_Silent_p.V368V|TNRC6C_ENST00000541771.1_Silent_p.V368V|TNRC6C_ENST00000544502.1_Silent_p.V368V|TNRC6C_ENST00000301624.4_Silent_p.V368V	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	368	Gly-rich.|Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GTCCTAGTGTCACCAGCCAGA	0.527000													19	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056435	9056435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9056435G>A	ENST00000397910.4	-	3	31214	c.31011C>T	c.(31009-31011)ttC>ttT	p.F10337F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10339	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTGGTAGTGAAGGTTGAAG	0.522000													28	69					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6939120	6939120	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6939120G>A	ENST00000251761.8	+	0	629				LEPREL2_ENST00000396725.2_RNA|LEPREL2_ENST00000606935.1_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						AAGTACAGACGAATGTCGGGA	0.592000													15	101					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54673325	54673325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54673325G>A	ENST00000376591.4	-	3	516	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	TMC4_ENST00000301187.4_Missense_Mutation_p.R123W|TMC4_ENST00000476013.2_5'UTR	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	129						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TTGGACCTCCGAAGTAGCCGC	0.592000													42	82					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45798932	45798932	+	Missense_Mutation	SNP	C	C	T	rs138507862		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45798932C>T	ENST00000397928.1	+	8	1512	c.1067C>T	c.(1066-1068)tCg>tTg	p.S356L	TRPM2_ENST00000300481.9_Missense_Mutation_p.S356L|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.S356L|TRPM2_ENST00000397932.2_Missense_Mutation_p.S356L	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	356						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GTGGAGGGCTCGGGCCGCGTG	0.642000													40	77					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10401081	10401081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10401081G>A	ENST00000226207.5	-	31	4429	c.4335C>T	c.(4333-4335)gcC>gcT	p.A1445A	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1445			A -> T (in a breast cancer sample; somatic mutation).			muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTTTGTCCAGGGCGGCACAGG	0.453000													41	62					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74548880	74548880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:74548880G>A	ENST00000263665.6	-	2	139	c.112C>T	c.(112-114)Cct>Tct	p.P38S		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	38	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GAACCAACAGGGAAAATGCTG	0.363000													11	125					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18257552	18257552	+	Silent	SNP	G	G	A	rs138099497		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18257552G>A	ENST00000286479.3	+	2	146	c.39G>A	c.(37-39)aaG>aaA	p.K13K	NAT2_ENST00000520116.1_Intron	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	13					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		TTGGCTATAAGAACTCTAGGA	0.373000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				56	167					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221429	161221429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161221429G>A	ENST00000327928.4	+	4	1133	c.1133G>A	c.(1132-1134)gGg>gAg	p.G378E		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	378	C1q.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						CCTGTCACTGGGAAGTTTAAC	0.448000													11	29					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40689277	40689277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40689277C>T	ENST00000298910.7	+	23	2985	c.2927C>T	c.(2926-2928)tCt>tTt	p.S976F	LRRK2_ENST00000343742.2_Missense_Mutation_p.S976F	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	976					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGCATTTCTTCTCTGGCTTCT	0.338000													17	61					0	0	1	0	0
C19orf33	64073	broad.mit.edu	37	19	38795318	38795318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38795318G>A	ENST00000591889.1	+	5	455	c.455G>A	c.(454-456)gGa>gAa	p.G152E	C19orf33_ENST00000588605.1_Silent_p.R84R|C19orf33_ENST00000301246.5_Missense_Mutation_p.D65N																							TTCGGACACGGATGTGAAGGT	0.692000													17	32					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86493638	86493638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86493638G>A	ENST00000394720.2	+	5	1711	c.1534G>A	c.(1534-1536)Gga>Aga	p.G512R	GRM3_ENST00000546348.1_Silent_p.R461R|GRM3_ENST00000361669.2_Silent_p.R869R|GRM3_ENST00000439827.1_Missense_Mutation_p.G514R|GRM3_ENST00000536043.1_Silent_p.R741R			Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	0				P -> A (in Ref. 3; AAH22496).	synaptic transmission	integral to plasma membrane		p.R869R(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCAATGGGCGGGAAGTCCTCG	0.473000													39	136					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135779312	135779312	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:135779312G>A	ENST00000375845.3	-	2	141	c.111C>T	c.(109-111)atC>atT	p.I37I	MAP3K19_ENST00000392917.3_Silent_p.I37I|MAP3K19_ENST00000392918.3_Silent_p.I37I|MAP3K19_ENST00000375844.3_Silent_p.I37I|MAP3K19_ENST00000358371.4_Silent_p.I37I|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392915.1_Silent_p.I54I	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		TTTGCAAGATGATGTTTTGAT	0.373000													18	35					0	0	1	0	0
BIRC3	330	broad.mit.edu	37	11	102201741	102201741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102201741G>A	ENST00000263464.3	+	6	3843	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K	BIRC3_ENST00000532808.1_Missense_Mutation_p.E365K	NM_001165.4	NP_001156.1	Q13489	BIRC3_HUMAN	baculoviral IAP repeat containing 3	365					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|ovary(3)|skin(1)	21	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TATCCATTTTGAACCTGGAGA	0.328000			T	MALT1	MALT								26	55					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150349343	150349343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150349343G>A	ENST00000218316.3	+	2	1357	c.1288G>A	c.(1288-1290)Ggt>Agt	p.G430S		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	430	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					GCCTGCCTCTGGTCACCCCAA	0.547000													145	100					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152708338	152708338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152708338G>A	ENST00000367255.5	-	54	8957	c.8356C>T	c.(8356-8358)Cac>Tac	p.H2786Y	SYNE1_ENST00000448038.1_Missense_Mutation_p.H2793Y|SYNE1_ENST00000423061.1_Missense_Mutation_p.H2793Y|SYNE1_ENST00000265368.4_Missense_Mutation_p.H2786Y|SYNE1_ENST00000341594.5_Missense_Mutation_p.H2825Y	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2786					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTCTCGTGTGATCTTCTGCC	0.493000										HNSCC(10;0.0054)			47	76					0	0	1	0	0
MESP1	55897	broad.mit.edu	37	15	90293986	90293986	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90293986G>A	ENST00000300057.4	-	1	555	c.477C>T	c.(475-477)tcC>tcT	p.S159S	MESP1_ENST00000559894.1_Intron	NM_018670.3	NP_061140.1	Q9BRJ9	MESP1_HUMAN	mesoderm posterior 1 homolog (mouse)	159					cardiac atrium formation|cardiac cell fate determination|cardiac vascular smooth muscle cell differentiation|cardiac ventricle formation|cardioblast anterior-lateral migration|cardioblast migration to the midline involved in heart field formation|endothelial cell differentiation|gastrulation|growth involved in heart morphogenesis|heart looping|lateral mesoderm development|negative regulation of endodermal cell fate specification|negative regulation of mesodermal cell fate specification|negative regulation of transcription, DNA-dependent|neurogenesis|Notch signaling pathway|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|positive regulation of hepatocyte differentiation|positive regulation of Notch signaling pathway|positive regulation of striated muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|secondary heart field specification|sinoatrial node cell differentiation|sinus venosus morphogenesis		sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|kidney(1)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			AGCCCCGAGGGGACCCCGCGT	0.736000													4	12					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25376587	25376587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25376587G>A	ENST00000255324.5	+	14	1879	c.1827G>A	c.(1825-1827)atG>atA	p.M609I	RNF17_ENST00000255325.5_Missense_Mutation_p.M610I|RNF17_ENST00000381921.1_Missense_Mutation_p.M609I	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	609					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTGTTTCAATGAAAGTTTTTA	0.363000													37	84					0	0	1	0	0
HBD	3045	broad.mit.edu	37	11	5254020	5254020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5254020C>T	ENST00000292901.3	-	3	373	c.324G>A	c.(322-324)aaG>aaA	p.K108K				P02042	HBD_HUMAN	hemoglobin, delta	108					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGAACCTTCTTACACACCT	0.393000													13	17					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42529856	42529856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:42529856G>A	ENST00000282030.5	+	4	847	c.551G>A	c.(550-552)aGg>aAg	p.R184K		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	184						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCTTACGAGAGGCCCCAGAAA	0.483000									Schinzel-Giedion syndrome				16	38					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065578	55065578	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55065578C>T	ENST00000526016.1	-	0	130					NR_038174.2																						ATGTTGTCTCCTTGCATTTAG	0.493000													12	29					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633707	116633707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:116633707G>A	ENST00000260210.4	-	4	621	c.598C>T	c.(598-600)Cct>Tct	p.P200S	BUD13_ENST00000375445.3_Missense_Mutation_p.P200S	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	200	Arg-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGGGGAGAAGGATCTGGAGAA	0.567000													45	127					0	0	1	0	0
GPC1	2817	broad.mit.edu	37	2	241401948	241401948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241401948C>T	ENST00000264039.2	+	3	914	c.666C>T	c.(664-666)tcC>tcT	p.S222S		NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	222					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		CTGCTCGCTCCTTTGTGCAGG	0.711000													14	36					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41333221	41333221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41333221C>T	ENST00000551295.2	+	12	1430	c.1313C>T	c.(1312-1314)cCt>cTt	p.P438L	CNTN1_ENST00000547849.1_Missense_Mutation_p.P438L|CNTN1_ENST00000547702.1_Missense_Mutation_p.P438L|CNTN1_ENST00000348761.2_Missense_Mutation_p.P427L|CNTN1_ENST00000360099.3_Missense_Mutation_p.P438L|CNTN1_ENST00000347616.1_Missense_Mutation_p.P438L	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	438	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GAATGCAAACCTAAAGCTGCA	0.398000													24	41					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31533831	31533831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31533831C>T	ENST00000215885.3	-	4	1183	c.931G>A	c.(931-933)Ggg>Agg	p.G311R		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	311					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						TGTGGTGGCCCCTTCCGAAGG	0.647000													59	138					0	0	1	0	0
RGAG4	340526	broad.mit.edu	37	X	71349761	71349761	+	Nonsense_Mutation	SNP	G	G	A	rs12401231		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:71349761G>A	ENST00000545866.1	-	1	1997	c.1630C>T	c.(1630-1632)Cga>Tga	p.R544*	RGAG4_ENST00000479991.1_Nonsense_Mutation_p.R544*|NHSL2_ENST00000540800.1_Intron			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	544										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					GGGCGTCTTCGAACTTGGCGT	0.602000													7	20					0	0	1	0	0
CD80	941	broad.mit.edu	37	3	119263605	119263605	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119263605C>T	ENST00000264246.3	-	3	572	c.210G>A	c.(208-210)aaG>aaA	p.K70K	CD80_ENST00000383668.3_Silent_p.K70K|CD80_ENST00000478182.1_Silent_p.K70K|CD80_ENST00000383669.3_Silent_p.K70K	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	70	Ig-like V-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding	p.K70N(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	GCACCATTTTCTTCTCCTTTT	0.458000													24	86					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75408412	75408412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75408412G>A	ENST00000394810.2	-	4	1147	c.998C>T	c.(997-999)tCc>tTc	p.S333F	SYNPO2L_ENST00000372873.4_Missense_Mutation_p.S109F|SYNPO2L_ENST00000372872.4_Missense_Mutation_p.S333F	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	333						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					GTCCAGCTCGGACTCACTCGT	0.627000													16	63					0	0	1	0	0
CBLN3	643866	broad.mit.edu	37	14	24898065	24898065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24898065C>T	ENST00000267406.6	-	1	666	c.196G>A	c.(196-198)Gag>Aag	p.E66K	CBLN3_ENST00000555436.1_Intron	NM_001039771.2	NP_001034860.1	Q6UW01	CBLN3_HUMAN	cerebellin 3 precursor	66						cell junction|extracellular region|synapse				central_nervous_system(1)|lung(3)	4				GBM - Glioblastoma multiforme(265;0.00159)		GGGGGTGCCTCTCCCAGGGCT	0.692000													3	14					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55419267	55419267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55419267G>A	ENST00000312422.2	+	1	888	c.888G>A	c.(886-888)atG>atA	p.M296I		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				AGAATGCAATGAAGAAACTGT	0.358000													78	214					0	0	1	0	0
OR6B2	389090	broad.mit.edu	37	2	240969787	240969787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:240969787G>A	ENST00000402971.2	-	1	119	c.60C>T	c.(58-60)gcC>gcT	p.A20A		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GCAGCCCTGGGGCCGTGGGGA	0.582000													6	58					0	0	1	0	0
CNTLN	54875	broad.mit.edu	37	9	17332635	17332635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:17332635C>T	ENST00000380647.3	+	10	1635	c.1551C>T	c.(1549-1551)tcC>tcT	p.S517S	CNTLN_ENST00000425824.1_Silent_p.S517S|CNTLN_ENST00000262360.5_Silent_p.S517S			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	517						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		GGTCTTTGTCCCCAAAGAGCT	0.398000													31	58					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47337533	47337533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47337533C>T	ENST00000400314.1	+	11	1045	c.707C>T	c.(706-708)cCt>cTt	p.P236L	PCBP3_ENST00000449640.1_Missense_Mutation_p.P236L|PCBP3_ENST00000468429.1_3'UTR|PCBP3_ENST00000400308.1_Missense_Mutation_p.P211L|PCBP3_ENST00000400310.1_Missense_Mutation_p.P236L|PCBP3_ENST00000400304.1_Missense_Mutation_p.P227L|PCBP3_ENST00000400309.1_Missense_Mutation_p.P236L			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	236					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TATGCCATCCCTCACCCGGAT	0.527000													36	77					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3658803	3658803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:3658803G>A	ENST00000404826.2	+	2	529	c.390G>A	c.(388-390)ggG>ggA	p.G130G	SDK1_ENST00000389531.3_Silent_p.G130G	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	130	Ig-like C2-type 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTGCCGAAGGGAGCTGGCCTT	0.478000													9	54					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46787381	46787381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46787381G>A	ENST00000230588.4	+	7	505	c.496G>A	c.(496-498)Gag>Aag	p.E166K		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	166	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			ATTTTACCACGAGCAGTCAAG	0.478000													72	150					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95053750	95053750	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95053750C>T	ENST00000329597.7	+	3	261	c.51C>T	c.(49-51)gcC>gcT	p.A17A	SERPINA5_ENST00000553780.1_Silent_p.A17A|SERPINA5_ENST00000554866.1_Silent_p.A17A|SERPINA5_ENST00000554276.1_Silent_p.A17A	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	17					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CTCAGGGGGCCTCCCTTCACC	0.592000													39	92					0	0	1	0	0
SLC22A4	6583	broad.mit.edu	37	5	131670542	131670542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131670542G>A	ENST00000200652.3	+	7	1352	c.1178G>A	c.(1177-1179)cGa>cAa	p.R393Q	AC034220.3_ENST00000437091.1_RNA|AC034220.3_ENST00000417795.1_RNA	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	393					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CTGCTATTGCGAACCCTGCCC	0.473000													60	223					0	0	1	0	0
BDKRB2	624	broad.mit.edu	37	14	96707226	96707226	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96707226C>T	ENST00000542454.2	+	3	3568	c.480C>T	c.(478-480)ctC>ctT	p.L160L	BDKRB2_ENST00000306005.3_Silent_p.L187L|RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000554311.1_Silent_p.L187L|BDKRB2_ENST00000539359.1_Silent_p.L160L			P30411	BKRB2_HUMAN	bradykinin receptor B2	187					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		GTACGCTGCTCCTGAGCTCAC	0.612000													21	72					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17692205	17692205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:17692205C>T	ENST00000399080.2	-	3	3369	c.3346G>A	c.(3346-3348)Ggc>Agc	p.G1116S		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	1116	Interaction with RAD51.									endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTTGAAATGCCATGTGGAAAG	0.323000													4	23					0	0	1	0	0
CDCA8	55143	broad.mit.edu	37	1	38173996	38173996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38173996C>T	ENST00000373055.1	+	10	1074	c.801C>T	c.(799-801)aaC>aaT	p.N267N	CDCA8_ENST00000327331.2_Silent_p.N267N	NM_001256875.1|NM_018101.3	NP_001243804.1|NP_060571.1	Q53HL2	BOREA_HUMAN	cell division cycle associated 8	267					cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(1)|stomach(1)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTTTTTAGAACCGTCTCGCCC	0.507000													24	59					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184039162	184039162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184039162C>T	ENST00000342981.4	+	9	1204	c.790C>T	c.(790-792)Ccg>Tcg	p.P264S	EIF4G1_ENST00000352767.3_Missense_Mutation_p.P271S|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000350481.5_Missense_Mutation_p.P100S|EIF4G1_ENST00000414031.1_Missense_Mutation_p.P224S|EIF4G1_ENST00000435046.2_Missense_Mutation_p.P68S|EIF4G1_ENST00000427845.1_Missense_Mutation_p.P177S|EIF4G1_ENST00000434061.2_Missense_Mutation_p.P68S|EIF4G1_ENST00000392537.2_Missense_Mutation_p.P177S|EIF4G1_ENST00000441154.1_Missense_Mutation_p.P100S|EIF4G1_ENST00000382330.3_Missense_Mutation_p.P271S|EIF4G1_ENST00000411531.1_Missense_Mutation_p.P224S|EIF4G1_ENST00000346169.2_Missense_Mutation_p.P264S|EIF4G1_ENST00000424196.1_Missense_Mutation_p.P271S|EIF4G1_ENST00000319274.6_Missense_Mutation_p.P264S	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	264					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GTCGCCTTCTCCGACCCCATC	0.567000													29	86					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65627693	65627693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65627693G>A	ENST00000327987.4	-	4	872	c.621C>T	c.(619-621)ttC>ttT	p.F207F		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	207	Ig-like C2-type 2.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCACACAGTGGAAGATGCCAC	0.597000													64	67					0	0	1	0	0
GPR78	27201	broad.mit.edu	37	4	8583216	8583216	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8583216C>T	ENST00000382487.4	+	1	924	c.507C>T	c.(505-507)ttC>ttT	p.F169F	GPR78_ENST00000509216.1_Intron	NM_080819.4	NP_543009.2	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	169					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|kidney(4)|large_intestine(1)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26						GTCCGCGCTTCGCAGCCTTCA	0.697000													4	8					0	0	1	0	0
ZNF197	10168	broad.mit.edu	37	3	44684449	44684449	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44684449C>T	ENST00000396058.1	+	5	1994	c.1827C>T	c.(1825-1827)ttC>ttT	p.F609F	RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron|ZNF197_ENST00000383744.4_Intron|ZNF197_ENST00000344387.4_Silent_p.F609F			O14709	ZN197_HUMAN	zinc finger protein 197	609					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		AGTCAAACTTCATTGACCATA	0.408000													30	53					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26885831	26885831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:26885831C>T	ENST00000231021.4	-	11	1946	c.1774G>A	c.(1774-1776)Gat>Aat	p.D592N		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	592	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.D592N(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CCTTGATTATCGCAGGCACAC	0.478000													9	19					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908361	164908361	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164908361C>A	ENST00000475390.1	-	2	701	c.258G>T	c.(256-258)agG>agT	p.R86S	SLITRK3_ENST00000241274.3_Missense_Mutation_p.R86S			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	86						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TCATAGAATTCCTCTGCAGAT	0.348000										HNSCC(40;0.11)			33	68					4.02929e-09	4.04425e-09	1	1	0
CHST15	51363	broad.mit.edu	37	10	125805533	125805533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:125805533C>T	ENST00000346248.5	-	2	838	c.196G>A	c.(196-198)Gaa>Aaa	p.E66K	CHST15_ENST00000421115.1_Missense_Mutation_p.E66K|CHST15_ENST00000435907.1_Missense_Mutation_p.E66K|CHST15_ENST00000462406.1_5'UTR	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	66					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						CCCCAGTTTTCGTTCCCTTCA	0.463000													9	81					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1953695	1953695	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1953695C>T	ENST00000382722.5	-	25	2705	c.2342_splice	c.e25-1	p.R781_splice	CACNA2D4_ENST00000585708.1_Splice_Site_p.R717_splice|CACNA2D4_ENST00000585732.1_Splice_Site_p.R642_splice|CACNA2D4_ENST00000586184.1_Splice_Site_p.R781_splice|CACNA2D4_ENST00000588077.1_Splice_Site_p.R717_splice|CACNA2D4_ENST00000539048.2_5'UTR|CACNA2D4_ENST00000587995.1_Splice_Site_p.R756_splice	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	781						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TCAGGAACTTCCTGCAAGGAG	0.562000													8	38					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75022211	75022211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75022211G>A	ENST00000261978.4	-	4	1402	c.1016C>T	c.(1015-1017)cCc>cTc	p.P339L	CTD-2207P18.1_ENST00000554552.1_lincRNA|LTBP2_ENST00000557425.1_Intron|LTBP2_ENST00000556690.1_Missense_Mutation_p.P339L	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	339					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTTACCCCAGGGGGATGAGGG	0.622000													21	128					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64633642	64633642	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64633642C>T	ENST00000498707.1	-	11	2026	c.1684G>A	c.(1684-1686)Gat>Aat	p.D562N	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.D534N	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	562	Disintegrin.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TCCGTCCCATCGGCCCAGGGT	0.522000													30	117					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29040886	29040886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29040886G>A	ENST00000257189.4	+	7	858	c.775G>A	c.(775-777)Gat>Aat	p.D259N		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	259	Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TAAAGTGAAAGATGTCAACGA	0.353000													20	40					0	0	1	0	0
GP9	2815	broad.mit.edu	37	3	128780787	128780787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:128780787G>A	ENST00000307395.4	+	3	427	c.205G>A	c.(205-207)Gga>Aga	p.G69R		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	69					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	CGTGCCCCCGGGAGCCTTTGA	0.682000													16	40					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22846811	22846811	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22846811C>T	ENST00000456783.2	+	4	584	c.340C>T	c.(340-342)Caa>Taa	p.Q114*		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				CAAAATATTTCAATGTGACAA	0.313000													8	20					0	0	1	0	0
PHYH	5264	broad.mit.edu	37	10	13325819	13325819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:13325819G>A	ENST00000396920.3	-	7	1052	c.648C>T	c.(646-648)ttC>ttT	p.F216F	PHYH_ENST00000396913.2_Silent_p.F133F|PHYH_ENST00000263038.4_Silent_p.F233F			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	233					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	GGATCCCGTGGAACATTTTGT	0.478000													39	427					0	0	1	0	0
CCK	885	broad.mit.edu	37	3	42299704	42299704	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42299704G>A	ENST00000396169.2	-	5	1139	c.234C>T	c.(232-234)tcC>tcT	p.S78S	CCK_ENST00000434608.1_Silent_p.S78S|CCK_ENST00000334681.5_Silent_p.S78S	NM_000729.4	NP_000720.1	P06307	CCKN_HUMAN	cholecystokinin	78					axonogenesis|eating behavior|neuron migration		neuropeptide hormone activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6		Ovarian(412;0.0728)		KIRC - Kidney renal clear cell carcinoma(284;0.219)		TCTTAACGATGGACATTCGTC	0.517000													26	60					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21205029	21205029	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21205029G>A	ENST00000381541.3	+	10	1396		c.e10-1		SLCO1B7_ENST00000554957.1_Splice_Site|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Splice_Site|SLCO1B3_ENST00000553473.1_Intron																							TATATTTTCAGAAATAGTCCA	0.388000													15	48					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201507489	201507489	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:201507489G>A	ENST00000374700.2	+	25	3053	c.2812G>A	c.(2812-2814)Gaa>Aaa	p.E938K	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	938					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TTGTATCACGGAAGTTGCAGC	0.512000													7	98					0	0	1	0	0
CCR8	1237	broad.mit.edu	37	3	39374734	39374734	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39374734G>A	ENST00000326306.4	+	2	1050	c.912G>A	c.(910-912)ggG>ggA	p.G304G	CCR8_ENST00000414803.1_3'UTR|CCR8_ENST00000545843.1_Silent_p.G221G	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	304					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CTTTTGTTGGGGAGAAGTTCA	0.418000													38	83					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209797190	209797190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209797190G>A	ENST00000391911.1	-	14	2521	c.2132C>T	c.(2131-2133)cCt>cTt	p.P711L	LAMB3_ENST00000356082.4_Missense_Mutation_p.P711L|LAMB3_ENST00000367030.3_Missense_Mutation_p.P711L	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	711	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CTCACCTGAAGGATCAGCACT	0.557000													38	73					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	352969	352969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:352969G>A	ENST00000343164.4	-	3	265	c.213C>T	c.(211-213)ttC>ttT	p.F71F	SLC6A13_ENST00000445055.2_Intron	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	71					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GGTAGGGGATGAAGAAGGCAC	0.527000													23	45					0	0	1	0	0
SCN4B	6330	broad.mit.edu	37	11	118015828	118015828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118015828C>T	ENST00000324727.4	-	2	324	c.178G>A	c.(178-180)Ggc>Agc	p.G60S	SCN4B_ENST00000529878.1_Intron	NM_001142349.1|NM_174934.3	NP_001135821.1|NP_777594.1	Q8IWT1	SCN4B_HUMAN	sodium channel, voltage-gated, type IV, beta subunit	60	Ig-like C2-type.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.33e-05)|Epithelial(105;0.00126)		TCCTCGAAGCCAAAGCAGCTG	0.562000											OREG0021380	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	164					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122551490	122551490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:122551490G>A	ENST00000264357.5	+	11	2030	c.1738G>A	c.(1738-1740)Gaa>Aaa	p.E580K	GRIA3_ENST00000542149.1_Missense_Mutation_p.E580K|GRIA3_ENST00000371256.5_Missense_Mutation_p.E580K|GRIA3_ENST00000371251.1_Missense_Mutation_p.E580K|GRIA3_ENST00000541091.1_Missense_Mutation_p.E564K	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	580					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CAGTCCTTATGAATGGCACTT	0.418000													41	149					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208390835	208390835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:208390835G>A	ENST00000367033.3	-	2	1190	c.433C>T	c.(433-435)Ctc>Ttc	p.L145F		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	145	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		AGGATGAAGAGGTCATCCAGC	0.572000													27	148					0	0	1	0	0
XAF1	54739	broad.mit.edu	37	17	6663021	6663021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6663021C>T	ENST00000361842.3	+	3	448	c.209C>T	c.(208-210)tCg>tTg	p.S70L	XAF1_ENST00000346752.4_Intron|XAF1_ENST00000438512.1_Missense_Mutation_p.S70L|XAF1_ENST00000441631.1_Intron	NM_017523.3	NP_059993.2	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1	70					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding			large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	6						CAGAAGTCCTCGCTGGAGTTT	0.517000													17	62					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233296076	233296076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233296076G>A	ENST00000258229.8	-	19	3704	c.3470C>T	c.(3469-3471)tCa>tTa	p.S1157L	PCNXL2_ENST00000520463.1_5'UTR|PCNXL2_ENST00000488780.2_Missense_Mutation_p.S290L	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1157						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AATGGGGTGTGAAATCCACAT	0.443000													23	47					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52211401	52211401	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52211401C>T	ENST00000282588.6	+	15	2423	c.1965C>T	c.(1963-1965)ggC>ggT	p.G655G		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	655					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				CTATTGGGGGCCTTGGTGGTG	0.468000													62	114					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19746500	19746500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19746500G>A	ENST00000203556.4	-	14	1495	c.1358C>T	c.(1357-1359)tCg>tTg	p.S453L	GMIP_ENST00000587238.1_Intron|GMIP_ENST00000445806.2_Intron	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	453					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GCCTGTGGACGAAGCCTTCAC	0.597000													33	159					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21236046	21236046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21236046G>A	ENST00000233242.1	-	25	4329	c.4202C>T	c.(4201-4203)tCc>tTc	p.S1401F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1401					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CACATTGTAGGAAAGCAGGTC	0.547000													51	107					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113920	94113920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94113920G>A	ENST00000243673.2	-	4	838	c.667C>T	c.(667-669)Ctc>Ttc	p.L223F	GPR83_ENST00000539203.2_Missense_Mutation_p.L181F	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	223						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GGCAGGCAGAGGGAGCGCACA	0.557000													13	40					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17488851	17488851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17488851C>T	ENST00000400588.1	-	1	261	c.154G>A	c.(154-156)Gag>Aag	p.E52K	GAB4_ENST00000523144.1_5'UTR	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	52	PH.									breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AGCTTCTTCTCGGGGGGCGAC	0.687000													6	14					0	0	1	0	0
SRPK1	6732	broad.mit.edu	37	6	35837432	35837432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35837432G>A	ENST00000373825.2	-	11	1523	c.1238C>T	c.(1237-1239)tCt>tTt	p.S413F	SRPK1_ENST00000423325.2_Missense_Mutation_p.S397F|SRPK1_ENST00000373822.1_Missense_Mutation_p.S306F			Q96SB4	SRPK1_HUMAN	SRSF protein kinase 1	413	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.S413Y(1)		endometrium(2)|large_intestine(10)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21						AGGTGTACAAGAGTCTGTTTC	0.418000													15	44					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47422305	47422305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47422305C>T	ENST00000361866.3	+	32	2354	c.2240C>T	c.(2239-2241)cCc>cTc	p.P747L	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	747	C-terminal globular domain.|VWFA 2.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CTCTGCAGCCCCGGCATCCAG	0.701000													4	6					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101765820	101765820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101765820G>A	ENST00000375001.3	+	8	1574	c.1151G>A	c.(1150-1152)gGa>gAa	p.G384E		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	384	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CCCACCGGGGGACCAACCCTC	0.597000													37	54					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875780	247875780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247875780G>A	ENST00000302084.2	-	1	325	c.278C>T	c.(277-279)tCa>tTa	p.S93L	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GCTTGTAAATGATATGGTCTG	0.483000													18	86					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15795653	15795653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15795653G>A	ENST00000550308.1	+	8	1326	c.946G>A	c.(946-948)Gag>Aag	p.E316K	CYP4F12_ENST00000324632.9_Missense_Mutation_p.E316K	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ATTGTCAGATGAGGATATAAG	0.493000													18	80					0	0	1	0	0
VN1R2	317701	broad.mit.edu	37	19	53762792	53762792	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53762792C>T	ENST00000341702.3	+	1	1248	c.1164C>T	c.(1162-1164)ttC>ttT	p.F388F	VN1R2_ENST00000598458.1_Intron	NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	388					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		ATAGACGATTCTTTCATGATT	0.438000													38	100					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97485261	97485261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:97485261G>A	ENST00000376705.2	+	2	1249	c.1225G>A	c.(1225-1227)Gag>Aag	p.E409K		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	409						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					GCAGCTTTACGAGTATGCAAA	0.572000													38	98					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187670	140187670	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140187670G>A	ENST00000530339.1	+	1	898	c.898G>A	c.(898-900)Gga>Aga	p.G300R	PCDHA4_ENST00000512229.2_Missense_Mutation_p.G300R|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.G300R|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1												p.G300*(2)		breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAATTACTGGACAAATTAT	0.358000													26	124					0	0	1	0	0
TRAV3	28690	broad.mit.edu	37	14	22192542	22192542	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22192542C>T	ENST00000390425.2	+	0	493																											AGCGACTCCGCTTTGTACTTC	0.478000													17	27					0	0	1	0	0
ABCF3	55324	broad.mit.edu	37	3	183907661	183907661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183907661C>T	ENST00000429586.2	+	14	1518	c.1333C>T	c.(1333-1335)Cgc>Tgc	p.R445C	EIF2B5_ENST00000444495.1_Intron|ABCF3_ENST00000292808.5_Missense_Mutation_p.R439C	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	445							ATP binding|ATPase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGACCGGTTTCGCTACAATGC	0.557000													12	61					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39008129	39008129	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39008129C>T	ENST00000355481.4	+	66	9947	c.9816C>T	c.(9814-9816)atC>atT	p.I3272I	RYR1_ENST00000359596.3_Silent_p.I3272I|RYR1_ENST00000360985.3_Silent_p.I3272I	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3272					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCATCGAGATCACGCTGCCCA	0.697000													23	33					0	0	1	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187692815	187692815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:187692815C>T	ENST00000295131.2	-	9	1837	c.1798G>A	c.(1798-1800)Gaa>Aaa	p.E600K		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	600					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CGTGTAATTTCCCCCATACAG	0.343000													22	46					0	0	1	0	0
PNLDC1	154197	broad.mit.edu	37	6	160239672	160239672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160239672G>A	ENST00000275275.5	+	16	1381	c.1210G>A	c.(1210-1212)Ggg>Agg	p.G404R	PNLDC1_ENST00000392167.3_Missense_Mutation_p.G415R	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1	404						integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CATCCGAGCGGGGGTCCCAAA	0.572000													6	36					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772291	4772291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:4772291C>T	ENST00000378191.4	+	2	742	c.361C>T	c.(361-363)Cca>Tca	p.P121S	AJAP1_ENST00000378190.3_Missense_Mutation_p.P121S	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	121					cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GGCCAAGCCCCCAGCTGCTGC	0.726000													5	9					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7110510	7110510	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7110510C>T	ENST00000306904.5	+	1	346	c.159C>T	c.(157-159)ttC>ttT	p.F53F		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	53	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTTCGCGTTCGTCACCTTTG	0.592000													6	19					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15262451	15262451	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15262451C>T	ENST00000256953.2	-	5	529	c.192_splice	c.e5-1	p.E65_splice	RERG_ENST00000546331.1_Splice_Site_p.E46_splice|RERG_ENST00000538313.1_Splice_Site_p.E65_splice|RERG_ENST00000536465.1_Splice_Site_p.E65_splice	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	65					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						ATGGTATCTTCCTGTTGGCAA	0.443000													78	299					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45292968	45292968	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:45292968G>A	ENST00000447098.2	-	16	2396	c.2385C>T	c.(2383-2385)gcC>gcT	p.A795A	PTCH2_ENST00000372192.3_Silent_p.A795A	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	795					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					CCTGGTCAAAGGCAGCCTGGA	0.637000									Basal Cell Nevus syndrome				14	88					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152468714	152468714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152468714G>A	ENST00000427231.2	-	78	11993	c.11791C>T	c.(11791-11793)Ctg>Ttg	p.L3931L	NEB_ENST00000604864.1_Silent_p.L3931L|NEB_ENST00000603639.1_Silent_p.L3931L|NEB_ENST00000172853.10_Silent_p.L3688L|NEB_ENST00000397345.3_Silent_p.L3931L|NEB_ENST00000409198.1_Silent_p.L3688L	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3931					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCATTGTCAGGGCATTATTC	0.458000													11	53					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50546582	50546582	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50546582G>A	ENST00000262794.5	+	4	543	c.460G>A	c.(460-462)Gga>Aga	p.G154R	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Missense_Mutation_p.G154R|MOV10L1_ENST00000545383.1_Missense_Mutation_p.G154R|MOV10L1_ENST00000540615.1_Missense_Mutation_p.G134R|MOV10L1_ENST00000475190.1_3'UTR	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	154					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding	p.G154R(1)		breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GCCCTGCAAGGGAGACTGGGT	0.532000													11	28					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76454647	76454647	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76454647C>T	ENST00000389840.5	-	62	10059	c.9935_splice	c.e62+1	p.R3312_splice	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Splice_Site_p.R3321_splice					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GAGCTGATACCTGTTCGCCAG	0.562000													41	76					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68597661	68597661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68597661C>T	ENST00000570495.1	+	5	1263	c.971C>T	c.(970-972)tCc>tTc	p.S324F	ZFP90_ENST00000563169.2_Missense_Mutation_p.S324F|ZFP90_ENST00000398253.2_Missense_Mutation_p.S324F|RP11-615I2.7_ENST00000571720.1_RNA			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	324					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CGCAGCTCCTCCCTTGTTCAA	0.502000													23	52					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39606906	39606906	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39606906G>A	ENST00000265708.4	-	18	2042	c.1939C>T	c.(1939-1941)Caa>Taa	p.Q647*	ADAM2_ENST00000379853.2_Nonsense_Mutation_p.Q491*|ADAM2_ENST00000347580.4_Nonsense_Mutation_p.Q628*|ADAM2_ENST00000521880.1_Nonsense_Mutation_p.Q584*	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	647					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		AGATCTGATTGAACTGAGCAA	0.383000													36	120					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42048690	42048690	+	Silent	SNP	G	G	A	rs35586296		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42048690G>A	ENST00000372584.1	-	3	2793	c.1779C>T	c.(1777-1779)atC>atT	p.I593I	HIVEP3_ENST00000429157.2_Silent_p.I593I|HIVEP3_ENST00000372583.1_Silent_p.I593I|HIVEP3_ENST00000247584.5_Silent_p.I593I	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	593	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AAGGTAATTCGATTGCCGGCT	0.582000													29	88					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13029625	13029625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:13029625C>T	ENST00000399002.2	+	2	424	c.150C>T	c.(148-150)ctC>ctT	p.L50L	SPTLC3_ENST00000378194.4_Silent_p.L50L|SPTLC3_ENST00000476791.1_3'UTR	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	50					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	ATGATAAGCTCATTGTTGAAT	0.358000													62	182					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129137225	129137225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129137225G>A	ENST00000505956.1	-	3	715	c.553C>T	c.(553-555)Cct>Tct	p.P185S	EFCAB12_ENST00000326085.3_Missense_Mutation_p.P185S	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		GACAGGGCAGGGGGCTCGGGC	0.602000													11	30					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62542622	62542622	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:62542622C>T	ENST00000512091.1	+	5	1095	c.348C>T	c.(346-348)taC>taT	p.Y116Y	LPHN3_ENST00000504896.1_Silent_p.Y116Y|LPHN3_ENST00000545650.1_Silent_p.Y116Y|LPHN3_ENST00000507164.1_Silent_p.Y184Y|LPHN3_ENST00000514157.1_Silent_p.Y116Y|LPHN3_ENST00000511324.1_Silent_p.Y184Y|LPHN3_ENST00000508693.1_Silent_p.Y184Y|LPHN3_ENST00000506746.1_Silent_p.Y184Y|LPHN3_ENST00000506700.1_Silent_p.Y116Y|LPHN3_ENST00000514591.1_Silent_p.Y116Y|LPHN3_ENST00000506720.1_Silent_p.Y184Y|LPHN3_ENST00000509896.1_Silent_p.Y184Y|LPHN3_ENST00000507625.1_Silent_p.Y184Y|LPHN3_ENST00000508946.1_Silent_p.Y116Y|LPHN3_ENST00000514996.1_Silent_p.Y116Y			Q9HAR2	LPHN3_HUMAN	latrophilin 3	116	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CCTATAAATACCTTGAAGTGC	0.398000													47	194					0	0	1	0	0
POU2F3	25833	broad.mit.edu	37	11	120169044	120169044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120169044G>A	ENST00000260264.4	+	4	243	c.209G>A	c.(208-210)gGa>gAa	p.G70E	POU2F3_ENST00000543440.2_Missense_Mutation_p.G68E	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	68					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		CTGAGTCAAGGACCTGCCATG	0.522000													105	161					0	0	1	0	0
KLF11	8462	broad.mit.edu	37	2	10186390	10186390	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:10186390T>A	ENST00000535335.1	+	2	321	c.105T>A	c.(103-105)gtT>gtA	p.V35V	KLF11_ENST00000305883.1_Silent_p.V52V|KLF11_ENST00000540845.1_Silent_p.V35V	NM_001177718.1	NP_001171189.1	O14901	KLF11_HUMAN	Kruppel-like factor 11	52					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		AGGCTCTTGTTTGTATGAGCT	0.537000													31	51					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21954013	21954013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21954013C>T	ENST00000261200.4	-	38	4614	c.4615G>A	c.(4615-4617)Gga>Aga	p.G1539R		NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1539	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCAAATACTCCATTTTCCTGA	0.378000													17	56					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3730588	3730588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3730588G>A	ENST00000541714.2	+	5	959	c.497G>A	c.(496-498)gGt>gAt	p.G166D	TJP3_ENST00000589378.1_Missense_Mutation_p.G175D|TJP3_ENST00000539908.2_Missense_Mutation_p.G130D|TJP3_ENST00000262968.9_Missense_Mutation_p.G185D|TJP3_ENST00000382008.3_Missense_Mutation_p.G166D|TJP3_ENST00000587686.1_Missense_Mutation_p.G185D	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	166						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGAGCCCAGGTGGTGGCTCT	0.706000													16	59					0	0	1	0	0
PTTG2	10744	broad.mit.edu	37	4	37962103	37962103	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:37962103C>T	ENST00000504686.1	+	1	48	c.48C>T	c.(46-48)acC>acT	p.T16T	TBC1D1_ENST00000261439.4_Intron|TBC1D1_ENST00000508802.1_Intron	NM_006607.2	NP_006598.2	Q9NZH5	PTTG2_HUMAN	pituitary tumor-transforming 2	16					chromosome organization|DNA metabolic process	cytoplasm|nucleus	SH3 domain binding			breast(1)|endometrium(1)|lung(4)|skin(1)	7						AACCAGGCACCCGTGTGGCTG	0.463000													4	55					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24372859	24372859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24372859G>A	ENST00000005284.3	+	4	1825	c.623G>A	c.(622-624)cGa>cAa	p.R208Q		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	208					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CAGCAGTTACGAGCCAAATCC	0.488000													29	103					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88669548	88669548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88669548G>A	ENST00000394480.1	-	13	1671	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F	NTRK3_ENST00000542733.2_Silent_p.F352F|NTRK3_ENST00000355254.2_Silent_p.F450F|NTRK3_ENST00000317501.3_Silent_p.F450F|NTRK3_ENST00000357724.2_Silent_p.F442F|NTRK3_ENST00000540489.2_Silent_p.F450F|NTRK3_ENST00000558306.1_Intron|NTRK3_ENST00000558676.1_Silent_p.F442F|NTRK3_ENST00000360948.2_Silent_p.F450F|NTRK3_ENST00000557856.1_Silent_p.F442F	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	450					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGATCATGACGAAGAGAACCA	0.453000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			22	58					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224437953	224437953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:224437953G>A	ENST00000281701.6	-	19	2509	c.2250C>T	c.(2248-2250)ccC>ccT	p.P750P	NVL_ENST00000340871.4_Silent_p.P561P|NVL_ENST00000361463.3_3'UTR|NVL_ENST00000469075.1_Silent_p.P659P|NVL_ENST00000482491.1_Silent_p.P474P|NVL_ENST00000391875.2_Silent_p.P644P	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	750						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		GATCTGCAGGGGGCGGTAAAC	0.398000													22	80					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100458845	100458845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100458845C>T	ENST00000354161.3	+	10	1429	c.1304C>T	c.(1303-1305)tCc>tTc	p.S435F	SLC12A9_ENST00000415287.1_Missense_Mutation_p.S346F|SLC12A9_ENST00000275729.3_Missense_Mutation_p.S346F|SLC12A9_ENST00000540482.1_Missense_Mutation_p.S435F|SLC12A9_ENST00000428758.1_Missense_Mutation_p.S435F	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	435						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					GTGGACCTGTCCTGCCTGAGC	0.632000													42	121					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135382142	135382142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135382142C>T	ENST00000442011.2	+	4	578	c.417C>T	c.(415-417)acC>acT	p.T139T	TGFBI_ENST00000305126.8_Silent_p.T139T	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	139	FAS1 1.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCAGCTTCACCATCTTCGCCC	0.622000													9	24					0	0	1	0	0
FAM189A2	9413	broad.mit.edu	37	9	72000820	72000820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72000820C>T	ENST00000257515.8	+	9	1233	c.813C>T	c.(811-813)acC>acT	p.T271T	FAM189A2_ENST00000469179.1_3'UTR|FAM189A2_ENST00000455972.1_Silent_p.T271T|FAM189A2_ENST00000303068.7_Silent_p.T106T	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	271						integral to membrane				endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CCTTGAGGACCAGGTCGAAGA	0.547000													10	33					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19483563	19483563	+	Missense_Mutation	SNP	G	G	A	rs142982513		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19483563G>A	ENST00000396229.2	+	11	2685	c.1936G>A	c.(1936-1938)Gag>Aag	p.E646K	TMC5_ENST00000219821.5_Missense_Mutation_p.E400K|TMC5_ENST00000542583.2_Missense_Mutation_p.E646K|TMC5_ENST00000541464.1_Intron|TMC5_ENST00000381414.4_Missense_Mutation_p.E646K|TMC5_ENST00000561503.1_Missense_Mutation_p.E287K|TMC5_ENST00000564959.1_Missense_Mutation_p.E329K	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	646						integral to membrane		p.E400K(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GTACAACTTAGAGGTAACCAA	0.562000													21	39					0	0	1	0	0
PRTN3	5657	broad.mit.edu	37	19	841055	841055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:841055C>T	ENST00000234347.5	+	1	93	c.47C>T	c.(46-48)gCc>gTc	p.A16V		NM_002777.3	NP_002768.3	P24158	PRTN3_HUMAN	proteinase 3	16					collagen catabolic process|positive regulation of cell proliferation|proteolysis		protein binding|serine-type endopeptidase activity			lung(1)|ovary(2)|urinary_tract(1)	4		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCTGCTGGCCTTGCTGCTG	0.652000													7	18					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155234488	155234488	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155234488G>A	ENST00000368361.4	-	9	1326	c.1011C>T	c.(1009-1011)caC>caT	p.H337H	CLK2_ENST00000361168.5_Silent_p.H336H|CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000536801.1_Silent_p.H337H|CLK2_ENST00000355560.4_Silent_p.H335H			P49760	CLK2_HUMAN	CDC-like kinase 2	337	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGTGCTATGGTGCTCATGGT	0.547000								Other conserved DNA damage response genes					28	73					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111156291	111156291	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111156291C>T	ENST00000360467.5	+	44	4542	c.4236C>T	c.(4234-4236)ccC>ccT	p.P1412P	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1412	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGCGAGGCCCCCCTGGGGCAC	0.736000													5	55					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51347726	51347726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51347726G>A	ENST00000266037.9	+	28	3009	c.2986G>A	c.(2986-2988)Gac>Aac	p.D996N		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	996						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CTTCCCTCGGGACTGGATGGT	0.463000													5	17					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34129929	34129929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34129929C>T	ENST00000389232.4	+	89	11818	c.11748C>T	c.(11746-11748)ttC>ttT	p.F3916F	RYR3_ENST00000415757.3_Silent_p.F3911F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3916					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGACATGTTCTTGAAACTTA	0.393000													11	16					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436483	56436483	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:56436483C>T	ENST00000327381.5	+	3	1750	c.1650C>T	c.(1648-1650)tcC>tcT	p.S550S		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	550						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			GGTCCATCTCCAACAACCGCA	0.592000													12	77					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17668875	17668875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17668875C>T	ENST00000375448.4	+	8	939	c.913C>T	c.(913-915)Ccg>Tcg	p.P305S	AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	305					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CACCCAGCCCCCGCAGGAGGT	0.642000													5	57					0	0	1	0	0
DAO	1610	broad.mit.edu	37	12	109283259	109283259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109283259G>A	ENST00000228476.3	+	4	528	c.324G>A	c.(322-324)aaG>aaA	p.K108K	DAO_ENST00000551281.1_Intron	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	108					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						CTTCCTGGAAGGACACAGTTC	0.537000													18	65					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31497190	31497190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31497190C>T	ENST00000330498.3	+	4	463	c.444C>T	c.(442-444)ttC>ttT	p.F148F		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	148					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						TCTCCCTTTTCCTGTACATCT	0.602000													13	54					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729932	18729932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18729932C>T	ENST00000440756.2	-	3	544	c.442G>A	c.(442-444)Gga>Aga	p.G148R	PSD3_ENST00000327040.8_Missense_Mutation_p.G148R|PSD3_ENST00000523619.1_Missense_Mutation_p.G83R			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	148					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TGTAATGTTCCGGAAATGATT	0.453000													21	156					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834305	101834305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101834305C>T	ENST00000506729.1	-	1	415	c.244G>A	c.(244-246)Gat>Aat	p.D82N	SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.D82N|SLCO6A1_ENST00000379810.1_Missense_Mutation_p.D82N|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.D82N|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.D82N			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	82						integral to membrane|plasma membrane	transporter activity	p.D82H(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AAACTGTCATCCACTTCTCCC	0.493000													53	114					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	163581	163581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:163581C>T	ENST00000283426.6	+	11	2376	c.2326C>T	c.(2326-2328)Ccc>Tcc	p.P776S		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	776					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TGCCAGGAGCCCCCCGGTCAC	0.652000													15	34					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17599924	17599924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17599924C>T	ENST00000375460.3	+	10	1177	c.1137C>T	c.(1135-1137)ttC>ttT	p.F379F		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	379					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGCAGGATTTCCCTTACAAAA	0.617000													21	34					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141509	133141509	+	Nonstop_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133141509T>G	ENST00000388996.4	-	15	3039	c.2619A>C	c.(2617-2619)taA>taC	p.*873Y	KCNQ3_ENST00000519445.1_Nonstop_Mutation_p.*861Y|KCNQ3_ENST00000521134.1_Nonstop_Mutation_p.*753Y	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	0					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTGACCTCTTTTAAATGGGCT	0.532000													14	51					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117803253	117803253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117803253C>T	ENST00000350763.4	-	19	5770	c.5359G>A	c.(5359-5361)Gaa>Aaa	p.E1787K	TNC_ENST00000535648.1_Missense_Mutation_p.E1332K|TNC_ENST00000542877.1_Missense_Mutation_p.E1424K|TNC_ENST00000423613.2_Missense_Mutation_p.E1514K|TNC_ENST00000346706.3_Missense_Mutation_p.E1241K|TNC_ENST00000537320.1_Missense_Mutation_p.E1150K|TNC_ENST00000341037.4_Missense_Mutation_p.E1605K|TNC_ENST00000345230.3_Missense_Mutation_p.E1150K|TNC_ENST00000340094.3_Missense_Mutation_p.E1423K	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1787	Fibronectin type-III 13.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GGTTCACTTTCCTCAAAGCCC	0.498000													29	80					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183097158	183097158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183097158C>T	ENST00000328913.3	-	3	499	c.202G>A	c.(202-204)Gag>Aag	p.E68K	MCF2L2_ENST00000414362.2_Missense_Mutation_p.E68K|MCF2L2_ENST00000447025.2_Missense_Mutation_p.E68K|MCF2L2_ENST00000473233.1_Missense_Mutation_p.E68K	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	68	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CCCGAAAACTCTGGGAACGTG	0.532000													12	26					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42149979	42149979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42149979C>T	ENST00000401548.3	+	17	1920	c.1880C>T	c.(1879-1881)tCc>tTc	p.S627F	MEI1_ENST00000300398.4_5'UTR|MEI1_ENST00000540833.1_Missense_Mutation_p.S367F|MEI1_ENST00000540880.1_Intron|MEI1_ENST00000400107.1_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	627							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CAGGTGTGTTCCAATTTCCTC	0.448000													41	61					0	0	1	0	0
SYNGR3	9143	broad.mit.edu	37	16	2042728	2042728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2042728G>A	ENST00000562045.1	+	2	1180	c.164G>A	c.(163-165)gGg>gAg	p.G55E	SYNGR3_ENST00000248121.2_Silent_p.G143G			O43761	SNG3_HUMAN	synaptogyrin 3	0	MARVEL.				positive regulation of transporter activity	cell junction|integral to plasma membrane|synaptic vesicle				endometrium(1)|lung(2)	3						CGCAGGCGGGGGACGCGGCGC	0.716000													7	7					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117103972	117103972	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117103972G>A	ENST00000307564.4	-	21	4069	c.3908C>T	c.(3907-3909)tCt>tTt	p.S1303F	AKNA_ENST00000223791.3_Missense_Mutation_p.S763F|AKNA_ENST00000374079.4_Missense_Mutation_p.S248F|AKNA_ENST00000374075.5_Missense_Mutation_p.S1222F|AKNA_ENST00000492875.1_5'UTR|AKNA_ENST00000374088.3_Missense_Mutation_p.S1303F	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1303			S -> P (in dbSNP:rs2250242).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GGGAGTTGAAGATGCTTTTCT	0.622000													16	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179456479	179456479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179456479C>T	ENST00000589042.1	-	303	60291	c.60067G>A	c.(60067-60069)Gac>Aac	p.D20023N	TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D17455N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D18382N|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D11150N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D11083N|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D10958N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18382	Fibronectin type-III 45.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAATCCAGTCCTGGGTGCCT	0.413000													39	99					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45461956	45461956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:45461956C>T	ENST00000303230.4	-	3	1060	c.1003G>A	c.(1003-1005)Gaa>Aaa	p.E335K		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	335						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ACAACCATTTCATTTAAAGAC	0.398000													15	33					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152490375	152490375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152490375G>A	ENST00000427231.2	-	65	9409	c.9207C>T	c.(9205-9207)atC>atT	p.I3069I	NEB_ENST00000604864.1_Silent_p.I3069I|NEB_ENST00000603639.1_Silent_p.I3069I|NEB_ENST00000172853.10_Intron|NEB_ENST00000397345.3_Silent_p.I3069I|NEB_ENST00000409198.1_Intron	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3069					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTCACTCTGGATCTTGGCTA	0.502000													110	330					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118105316	118105316	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:118105316G>A	ENST00000425217.1	-	5	1101	c.1047C>T	c.(1045-1047)tcC>tcT	p.S349S	KSR2_ENST00000302438.5_Silent_p.S75S|KSR2_ENST00000339824.5_Silent_p.S378S|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	378					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGGAGGGGTGGAAGGCAGGA	0.627000													3	14					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37346323	37346323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:37346323G>A	ENST00000373091.3	-	3	478	c.462C>T	c.(460-462)ccC>ccT	p.P154P	GRIK3_ENST00000373093.4_Silent_p.P154P	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	154					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AGGCGTAGTCGGGGTAGAGGT	0.607000													48	118					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606135	21606135	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:21606135C>T	ENST00000281523.2	-	3	725	c.207G>A	c.(205-207)ggG>ggA	p.G69G	ZNF385D-AS1_ENST00000412369.1_RNA|ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	69						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						GAAGAGGAACCCCGAATGTAT	0.343000													24	84					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46267842	46267842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:46267842C>T	ENST00000372004.3	+	14	2819	c.2603C>T	c.(2602-2604)cCt>cTt	p.P868L	NCOA3_ENST00000371997.3_Missense_Mutation_p.P878L|NCOA3_ENST00000371998.3_Missense_Mutation_p.P868L|NCOA3_ENST00000341724.6_Intron	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	868					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GGCTCAAGTCCTCCAGTAAAA	0.433000													36	81					0	0	1	0	0
MMP19	4327	broad.mit.edu	37	12	56235010	56235010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56235010C>T	ENST00000322569.4	-	3	275	c.184G>A	c.(184-186)Gaa>Aaa	p.E62K	MMP19_ENST00000409200.3_Missense_Mutation_p.E62K|MMP19_ENST00000547487.1_5'UTR|MMP19_ENST00000548629.1_Missense_Mutation_p.E62K	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	62					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						TCAGATGCTTCCTGAAAAGCT	0.527000													22	55					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68688074	68688074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68688074C>T	ENST00000283916.6	-	10	1336	c.1238G>A	c.(1237-1239)aGg>aAg	p.R413K	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11D_ENST00000545541.1_Missense_Mutation_p.R296K	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	413	Peptidase S1.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						AGTTTGTTGCCTAATCCAGTC	0.463000													13	214					0	0	1	0	0
SWAP70	23075	broad.mit.edu	37	11	9715787	9715787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:9715787C>T	ENST00000318950.6	+	2	297	c.194C>T	c.(193-195)tCc>tTc	p.S65F	SWAP70_ENST00000447399.2_Missense_Mutation_p.S65F	NM_015055.2	NP_055870.2	Q9UH65	SWP70_HUMAN	SWAP switching B-cell complex 70kDa subunit	65						cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	11				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		GGTCCAGTGTCCAACCAGGGC	0.453000													25	107					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145095669	145095669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145095669C>T	ENST00000377470.3	+	3	1069	c.967C>T	c.(967-969)Ccc>Tcc	p.P323S	SPATC1_ENST00000447830.2_Missense_Mutation_p.P323S	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	323										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			tgcatctgtccccacctcccc	0.662000													6	18					0	0	1	0	0
SULT1C4	27233	broad.mit.edu	37	2	108999633	108999633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108999633G>A	ENST00000272452.2	+	4	804	c.478G>A	c.(478-480)Gga>Aga	p.G160R	SULT1C4_ENST00000409309.3_Intron	NM_006588.2	NP_006579.2	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member 4	160					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						TCCTGCTCCAGGAACATGGGA	0.413000													52	93					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52556489	52556489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52556489G>A	ENST00000261839.7	-	9	1106	c.945C>T	c.(943-945)ttC>ttT	p.F315F	MYO5C_ENST00000443683.2_Silent_p.F258F|MYO5C_ENST00000541028.1_5'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	315	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AATCCTCCTTGAAACCTAAAA	0.443000													11	31					0	0	1	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261887	21261887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21261887G>A	ENST00000311620.5	+	2	1073	c.1000G>A	c.(1000-1002)Gat>Aat	p.D334N		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	334								p.D334N(1)		NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		GTGGGATGACGATGAAGTGGA	0.517000													17	32					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6912853	6912853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6912853C>T	ENST00000299459.2	-	1	977	c.879G>A	c.(877-879)aaG>aaA	p.K293K		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K293K(1)		breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCTTCACATCCTTGTTTCTCA	0.458000													23	62					0	0	1	0	0
CST4	1472	broad.mit.edu	37	20	23667831	23667831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23667831C>T	ENST00000217423.3	-	2	306	c.236G>A	c.(235-237)gGg>gAg	p.G79E		NM_001899.2	NP_001890.1	P01036	CYTS_HUMAN	cystatin S	79						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	16	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					ATTCACCCCCCCAAAGGTCTG	0.552000													45	186					0	0	1	0	0
GCLC	2729	broad.mit.edu	37	6	53364951	53364951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:53364951G>A	ENST00000229416.6	-	15	2077	c.1594C>T	c.(1594-1596)Cct>Tct	p.P532S		NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	532					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	ATCAGTCCAGGAAACACACCT	0.478000													20	108					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153221832	153221832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153221832G>A	ENST00000310441.7	-	16	3632	c.2666C>T	c.(2665-2667)aCc>aTc	p.T889I	HCFC1_ENST00000369984.4_Missense_Mutation_p.T889I|HCFC1_ENST00000354233.3_Missense_Mutation_p.T820I	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	889	Interaction with GABP2.|Interaction with ZBTB17.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGTGGAGACGGTGCCTGTCAC	0.642000													10	48					0	0	1	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33016598	33016598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33016598G>A	ENST00000357505.6	-	7	2135	c.2031C>T	c.(2029-2031)tcC>tcT	p.S677S	N4BP2L2_ENST00000399396.3_Silent_p.S692S|N4BP2L2_ENST00000504114.1_Silent_p.S677S|N4BP2L2_ENST00000380121.3_5'UTR|N4BP2L2_ENST00000446957.2_Silent_p.S595S	NM_001278432.1	NP_001265361.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	0										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GTAGCTCAAGGGAACGGTAGT	0.393000													7	22					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50339780	50339780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50339780C>T	ENST00000376020.2	-	9	4422	c.4397G>A	c.(4396-4398)cGa>cAa	p.R1466Q	SHROOM4_ENST00000460112.3_Missense_Mutation_p.R1350Q|SHROOM4_ENST00000289292.7_Missense_Mutation_p.R1466Q	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1466	ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					CTCCAGCTCTCGCTGTTCAAT	0.502000													21	17					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57866755	57866755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57866755C>T	ENST00000443917.2	+	3	616	c.277C>T	c.(277-279)Cct>Tct	p.P93S	ZNF304_ENST00000598744.1_Intron|ZNF304_ENST00000391705.3_Intron|ZNF304_ENST00000282286.5_Intron			Q9HCX3	ZN304_HUMAN	zinc finger protein 304	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		AGGGCATGGCCCTGCTGAATG	0.522000													13	50					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8235340	8235340	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8235340G>A	ENST00000520004.1	-	3	843	c.579C>T	c.(577-579)ccC>ccT	p.P193P	SGK223_ENST00000330777.4_Silent_p.P193P			Q86YV5	SG223_HUMAN		193							ATP binding|non-membrane spanning protein tyrosine kinase activity										AAGGAAATGAGGGTTTTTCTT	0.617000													30	90					0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223226	35223226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35223226G>A	ENST00000338513.1	+	2	468	c.295G>A	c.(295-297)Gag>Aag	p.E99K		NM_005268.3	NP_005259.1	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	99					cell communication|epidermis development	connexon complex|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				GGCCTACCGGGAGGTTCAGGA	0.612000													26	77					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369416	56369416	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56369416C>T	ENST00000301295.6	+	3	1079	c.657C>T	c.(655-657)atC>atT	p.I219I	NLRP4_ENST00000587891.1_Silent_p.I144I|NLRP4_ENST00000346986.5_Silent_p.I219I	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	219	NACHT.						ATP binding	p.I219I(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TAACAGAGATCGTGTCTCAAC	0.537000													38	84					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155212010	155212010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155212010C>T	ENST00000460012.1	-	17	2369	c.2012G>A	c.(2011-2013)cGa>cAa	p.R671Q	PLCH1_ENST00000414191.1_Missense_Mutation_p.R671Q|PLCH1_ENST00000340059.7_Missense_Mutation_p.R689Q|PLCH1_ENST00000334686.6_Missense_Mutation_p.R671Q|PLCH1_ENST00000447496.2_Missense_Mutation_p.R689Q|PLCH1_ENST00000494598.1_Missense_Mutation_p.R689Q			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	689	PI-PLC Y-box.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CTGCATCATTCGTCCTTCAGA	0.418000													21	73					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47400029	47400029	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47400029C>T	ENST00000457840.2	-	7	743	c.440G>A	c.(439-441)tGg>tAg	p.W147*	CYP4A11_ENST00000475477.1_Intron|CYP4A11_ENST00000310638.4_Missense_Mutation_p.G303R|CYP4A11_ENST00000371904.4_Missense_Mutation_p.G304R|CYP4A11_ENST00000371905.1_Missense_Mutation_p.G303R			Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	0					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	AAGATGCTCCCATTCTCCATC	0.532000													19	24					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39913526	39913526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39913526C>T	ENST00000425673.1	+	16	2070	c.1745C>T	c.(1744-1746)cCa>cTa	p.P582L	PLEKHG2_ENST00000458508.2_Missense_Mutation_p.P552L|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.P611L|PLEKHG2_ENST00000409797.2_Intron			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	611					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGCCTTCCCCACTCCACGTC	0.562000													15	47					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14816850	14816850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14816850C>T	ENST00000380881.4	-	16	3384	c.2569G>A	c.(2569-2571)Gaa>Aaa	p.E857K	FREM1_ENST00000380880.3_Missense_Mutation_p.E856K|FREM1_ENST00000422223.2_Missense_Mutation_p.E856K			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	856					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		tgaagaacttcagttccatca	0.428000													3	2					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913201	6913201	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6913201G>A	ENST00000299459.2	-	1	629	c.531C>T	c.(529-531)ttC>ttT	p.F177F		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCTCACAAAAGAAATGAGCAA	0.493000													9	54					0	0	1	0	0
CD74	972	broad.mit.edu	37	5	149792299	149792299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149792299C>T	ENST00000353334.6	-	1	193	c.14G>A	c.(13-15)aGa>aAa	p.R5K	CD74_ENST00000377795.3_Missense_Mutation_p.R5K|CD74_ENST00000009530.7_Missense_Mutation_p.R5K|CD74_ENST00000524315.1_Missense_Mutation_p.R5K	NM_001025159.2|NM_004355.3	NP_001020330.1|NP_004346.1	P04233	HG2A_HUMAN	CD74 molecule, major histocompatibility complex, class II invariant chain	5					antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTCCTGCTTCTCCTCCTGTG	0.607000			T	ROS1	NSCLC								97	222					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56910937	56910937	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:56910937G>A	ENST00000520220.2	+	11	1294	c.1020G>A	c.(1018-1020)aaG>aaA	p.K340K	LYN_ENST00000519728.1_Silent_p.K361K|LYN_ENST00000420292.1_3'UTR	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	361	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			TCGAGCGGAAGAACTACATTC	0.448000													16	48					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43936011	43936011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43936011G>A	ENST00000262726.7	-	28	4128	c.3875C>T	c.(3874-3876)cCc>cTc	p.P1292L	EFCAB6_ENST00000461800.1_5'UTR|EFCAB6_ENST00000396231.2_Missense_Mutation_p.P1140L	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				ACTCACACAGGGGTGGCTCTG	0.612000													12	57					0	0	1	0	0
GLS2	27165	broad.mit.edu	37	12	56868895	56868895	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56868895C>T	ENST00000311966.4	-	10	1208		c.e10-1		GLS2_ENST00000476991.1_Splice_Site	NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)						cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TGACTGGAATCTGAAGCAAAC	0.468000													66	133					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51890209	51890209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51890209C>T	ENST00000371117.3	-	32	4674	c.4399G>A	c.(4399-4401)Ggg>Agg	p.G1467R	PKHD1_ENST00000340994.4_Missense_Mutation_p.G1467R	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1467	IPT/TIG 9.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTGGTTAGCCCATTGACCAGG	0.537000													18	33					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39724454	39724454	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39724454C>T	ENST00000246662.4	-	6	1419	c.1354G>A	c.(1354-1356)Gag>Aag	p.E452K	KRT9_ENST00000588431.1_Missense_Mutation_p.E219K	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	452	Coil 2.|Rod.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				TGGTAGGTCTCGATTTCCTTC	0.552000													20	24					0	0	1	0	0
NKX6-1	4825	broad.mit.edu	37	4	85419214	85419214	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85419214G>A	ENST00000295886.4	-	1	389	c.168C>T	c.(166-168)tcC>tcT	p.S56S		NM_006168.2	NP_006159.2	P78426	NKX61_HUMAN	NK6 homeobox 1	56	Poly-Ser.				detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	15		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)		gcgacgaggaggacgacgacg	0.746000													4	4					0	0	1	0	0
BBC3	27113	broad.mit.edu	37	19	47725025	47725025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47725025G>A	ENST00000449228.1	-	4	882	c.719C>T	c.(718-720)tCg>tTg	p.S240L	BBC3_ENST00000439096.2_3'UTR|BBC3_ENST00000300880.7_Missense_Mutation_p.S80L|BBC3_ENST00000341983.4_3'UTR	NM_001127240.2	NP_001120712.1	Q9BXH1	BBC3_HUMAN	BCL2 binding component 3	0					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to hypoxia|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of growth|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|positive regulation of thymocyte apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|reduction of endoplasmic reticulum calcium ion concentration|release of cytochrome c from mitochondria|release of sequestered calcium ion into cytosol	cytosol|mitochondrial outer membrane	protein binding			endometrium(1)|lung(2)|skin(1)	4		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.000179)|OV - Ovarian serous cystadenocarcinoma(262;0.00029)|Epithelial(262;0.0103)|GBM - Glioblastoma multiforme(486;0.0234)		CCTGCCCCCCGAGTCCCTGAC	0.672000													9	15					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103471421	103471421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103471421C>T	ENST00000358392.2	-	18	2171	c.1854G>A	c.(1852-1854)ccG>ccA	p.P618P	COL11A1_ENST00000512756.1_Silent_p.P490P|COL11A1_ENST00000461720.1_5'UTR|COL11A1_ENST00000353414.4_Silent_p.P567P|COL11A1_ENST00000370096.3_Silent_p.P606P	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	606	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.P606P(2)|p.P618P(2)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGCAGACCCGGAAGTCCAT	0.358000													22	123					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1496876	1496876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1496876G>A	ENST00000421627.2	+	2	151	c.17G>A	c.(16-18)gGa>gAa	p.G6E		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	85					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GGCCTTTCCGGAAGTCGGACC	0.692000													4	14					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32752402	32752402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32752402G>A	ENST00000380250.3	+	21	3006	c.2510G>A	c.(2509-2511)aGc>aAc	p.S837N		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	837					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GATGTGAAAAGCCCTTCCCAT	0.512000													13	131					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018171	62018171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62018171C>T	ENST00000578147.1	-	24	5547	c.5471G>A	c.(5470-5472)gGg>gAg	p.G1824E	SCN4A_ENST00000435607.1_Missense_Mutation_p.G1824E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1824					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CACAGTCTGCCCTGGGGGAGG	0.682000													5	63					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024332	76024332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76024332C>T	ENST00000393004.2	-	5	1437	c.1216G>A	c.(1216-1218)Gaa>Aaa	p.E406K	FILIP1_ENST00000237172.7_Missense_Mutation_p.E406K|FILIP1_ENST00000370020.1_Missense_Mutation_p.E307K|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	406										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TTCCTCAATTCCCTACACTGG	0.423000													14	143					0	0	1	0	0
FAM45B	55855	broad.mit.edu	37	X	129629752	129629752	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:129629752G>A	ENST00000458525.1	-	0	1015				FAM45B_ENST00000592932.1_RNA																							GTGTGGCACCGACAGGACTGG	0.537000													18	36					0	0	1	0	0
VGLL2	245806	broad.mit.edu	37	6	117586980	117586980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117586980C>T	ENST00000326274.5	+	1	244	c.54C>T	c.(52-54)ttC>ttT	p.F18F	VGLL2_ENST00000352536.3_Silent_p.F18F	NM_182645.2	NP_872586.1	Q8N8G2	VGLL2_HUMAN	vestigial like 2 (Drosophila)	18					transcription, DNA-dependent	nucleus				central_nervous_system(1)|kidney(1)|lung(3)	5				GBM - Glioblastoma multiforme(226;0.0254)|all cancers(137;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.0757)		AGCCCTACTTCGCAGCCGCCT	0.577000													11	21					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22291883	22291883	+	Nonsense_Mutation	SNP	C	C	T	rs146341538		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:22291883C>T	ENST00000324559.8	+	18	2241	c.1924C>T	c.(1924-1926)Cga>Tga	p.R642*		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	642						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTGGAGACGCCGAAAAGCTCG	0.418000													22	81					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172674507	172674507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172674507G>A	ENST00000351008.3	-	6	1224	c.1041C>T	c.(1039-1041)ttC>ttT	p.F347F		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	347					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GAGTTTTTGTGAAAGCATCTT	0.333000													18	43					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155486985	155486985	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155486985G>A	ENST00000302068.4	+	2	203	c.140G>A	c.(139-141)cGa>cAa	p.R47Q	FGB_ENST00000502545.1_3'UTR|FGB_ENST00000509493.1_Intron	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	47	Beta-chain polymerization, binding distal domain of another fibrin.		Missing (in New York-1).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CGTGGTCATCGACCCCTTGAC	0.522000													7	56					0	0	1	0	0
GABRA5	2558	broad.mit.edu	37	15	27128577	27128577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:27128577C>T	ENST00000335625.5	+	6	1258	c.370C>T	c.(370-372)Ctt>Ttt	p.L124F	GABRB3_ENST00000541819.2_Intron|GABRA5_ENST00000557449.1_Intron|GABRA5_ENST00000355395.5_Missense_Mutation_p.L124F|GABRA5_ENST00000400081.3_Missense_Mutation_p.L124F	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	124					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAACAACCTCCTTGCCAGCAA	0.547000													23	80					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220503474	220503474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220503474C>T	ENST00000358055.3	+	19	3418	c.2906C>T	c.(2905-2907)tCg>tTg	p.S969L	SLC4A3_ENST00000373762.3_Missense_Mutation_p.S996L|SLC4A3_ENST00000273063.6_Missense_Mutation_p.S996L|SLC4A3_ENST00000373760.2_Missense_Mutation_p.S969L|SLC4A3_ENST00000317151.3_Missense_Mutation_p.S969L			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	969	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GATAAGCGCTCGTGGTTCATC	0.602000													18	53					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	57016149	57016149	+	Splice_Site	SNP	C	C	T	rs111642444		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57016149C>T	ENST00000200676.3	+	14	1451	c.1321_splice	c.e14+1	p.R441_splice	CETP_ENST00000566128.1_Splice_Site_p.R376_splice|CETP_ENST00000379780.2_Splice_Site_p.R381_splice	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	441					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						GGTCATGTCTCGTAAGTGTGG	0.592000													16	55					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140235691	140235691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140235691C>T	ENST00000307360.5	+	1	58	c.58C>T	c.(58-60)Ctc>Ttc	p.L20F	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.L20F|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTCTTCTCCTCGCAGCCTG	0.592000													18	51					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111342415	111342415	+	Missense_Mutation	SNP	G	G	A	rs138877502		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111342415G>A	ENST00000308208.5	+	11	1608	c.1366G>A	c.(1366-1368)Gac>Aac	p.D456N	CCDC63_ENST00000552694.1_Missense_Mutation_p.D377N|CCDC63_ENST00000545036.1_Missense_Mutation_p.D416N	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	456								p.D456N(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GAAGACCAACGACCTGCTGCT	0.597000													32	90					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70118404	70118404	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70118404C>T	ENST00000253925.7	+	2	341	c.126C>T	c.(124-126)tcC>tcT	p.S42S	PPFIA1_ENST00000389547.3_Silent_p.S42S	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	42					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGATGGTCTCCATGCTAGAAG	0.532000													20	104					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94100891	94100891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94100891G>A	ENST00000553484.1	+	33	5961	c.5807G>A	c.(5806-5808)gGa>gAa	p.G1936E	UNC79_ENST00000555664.1_Intron|UNC79_ENST00000256339.4_Missense_Mutation_p.G1737E|UNC79_ENST00000393151.2_Missense_Mutation_p.G1914E			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1914						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ATGAAAAGGGGATCCCTGGGA	0.468000													31	78					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94134036	94134036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94134036G>A	ENST00000243673.2	-	1	549	c.378C>T	c.(376-378)ccC>ccT	p.P126P	GPR83_ENST00000539203.2_Silent_p.P126P	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	126						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCAAAGTGAAGGGGGTGTTGA	0.577000													12	25					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79028721	79028721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79028721C>T	ENST00000446378.2	+	2	4164	c.4133C>T	c.(4132-4134)tCt>tTt	p.S1378F		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1378						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ACAGATTCATCTCTTATCACT	0.393000													16	30					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348411	140348411	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348411T>C	ENST00000289269.5	+	1	2592	c.2060T>C	c.(2059-2061)aTc>aCc	p.I687T	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		687	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTCCAAAATCCTCCCTGAC	0.443000													21	61					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92928218	92928218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:92928218G>A	ENST00000373079.3	-	1	349	c.86C>T	c.(85-87)tCt>tTt	p.S29F	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	29	Ser-rich.				nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TTCTTCCCCAGAATCACTAGT	0.557000													19	21					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42161469	42161469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42161469G>A	ENST00000444063.1	+	9	1203	c.1071G>A	c.(1069-1071)atG>atA	p.M357I	L3MBTL1_ENST00000427442.2_Missense_Mutation_p.M425I|L3MBTL1_ENST00000373134.1_Missense_Mutation_p.M357I|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.M357I|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.M425I			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	357					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						TTGACCGCATGAACCCGTCCC	0.587000													17	212					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36361338	36361338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36361338C>T	ENST00000405275.2	+	3	250	c.7C>T	c.(7-9)Cgg>Tgg	p.R3W	CTNNBL1_ENST00000361383.6_Missense_Mutation_p.R30W			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	30					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				GAAGATGCGTCGGAAACAAAC	0.478000													20	62					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19981479	19981479	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19981479C>T	ENST00000255006.6	+	12	2883	c.2734C>T	c.(2734-2736)Cga>Tga	p.R912*	RIN2_ENST00000484638.1_3'UTR|RIN2_ENST00000440354.2_Nonsense_Mutation_p.R430*	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	863					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						GCTGCACAGCCGACCACAGCC	0.522000													13	64					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62045598	62045598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62045598C>T	ENST00000578147.1	-	6	897	c.821G>A	c.(820-822)gGa>gAa	p.G274E	SCN4A_ENST00000435607.1_Missense_Mutation_p.G274E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	274					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CCTCAGGTTTCCCATGAAGAG	0.562000													31	84					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665909	19665909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19665909G>A	ENST00000328041.6	+	12	1425	c.1228G>A	c.(1228-1230)Gaa>Aaa	p.E410K		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	410						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGCTGGCAACGAAACAgagaa	0.537000													20	44					0	0	1	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170165	20170165	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20170165G>A	ENST00000338912.5	-	0	106																											GATCCTCACTGAGGCCCCAGG	0.572000													32	57					0	0	1	0	0
LOC653786	653786	broad.mit.edu	37	16	22558274	22558274	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:22558274C>T	ENST00000550753.1	+	0	1256					NR_003676.2																						TGGTTATTATCTCTTTTTAGA	0.433000													10	80					0	0	1	0	0
KLRD1	3824	broad.mit.edu	37	12	10462072	10462072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10462072G>A	ENST00000381908.3	+	2	353	c.93G>A	c.(91-93)ttG>ttA	p.L31L	KLRD1_ENST00000538997.1_Intron|KLRD1_ENST00000381907.4_Silent_p.L31L|KLRD1_ENST00000350274.5_Intron|KLRD1_ENST00000336164.4_Silent_p.L31L|KLRD1_ENST00000543777.1_Silent_p.L31L|KLRD1_ENST00000543420.1_Silent_p.L31L			Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D, member 1	31					cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	10						GAATTTTGTTGAAAAATTGTA	0.328000													21	39					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537083	5537083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5537083C>T	ENST00000380184.1	-	1	852	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	197								p.E197*(1)		endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		TCTAGATGTTCTGAAATGAAC	0.493000													52	134					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378682	114378682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:114378682C>T	ENST00000312719.5	-	5	1968	c.780G>A	c.(778-780)acG>acA	p.T260T	HS3ST5_ENST00000411826.1_Silent_p.T260T|RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000523087.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	260					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GCAGAGGTTCCGTGATGAGGC	0.428000													22	45					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80223044	80223044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:80223044G>A	ENST00000392959.1	-	4	1216	c.605C>T	c.(604-606)tCc>tTc	p.S202F	LCA5_ENST00000369846.4_Missense_Mutation_p.S202F|LCA5_ENST00000467898.2_Missense_Mutation_p.S202F	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	202					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TTTCTGTAAGGAAAATTTTGT	0.378000													42	44					0	0	1	0	0
C6orf15	29113	broad.mit.edu	37	6	31079453	31079453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31079453C>T	ENST00000259870.3	-	2	686	c.683G>A	c.(682-684)gGa>gAa	p.G228E		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	228	Gly-rich.									endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						GGGCCTCGTTCCCCAACCAGT	0.592000													8	65					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8976750	8976750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8976750G>A	ENST00000397910.4	-	73	42519	c.42316C>T	c.(42316-42318)Ctt>Ttt	p.L14106F	MUC16_ENST00000380951.5_Missense_Mutation_p.L747F|MUC16_ENST00000596956.1_5'UTR	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14137	SEA 14.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGTGCTGAAGGACCCCCTCG	0.552000													11	33					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16822601	16822601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:16822601C>T	ENST00000355661.3	-	17	2339	c.2329G>A	c.(2329-2331)Gaa>Aaa	p.E777K	PLEKHA7_ENST00000448080.2_Missense_Mutation_p.E777K|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.E777K|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	777					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TTCAGGTATTCGTTCCAAGCA	0.498000													48	174					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179599149	179599149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179599149G>A	ENST00000589042.1	-	52	15626	c.15402C>T	c.(15400-15402)atC>atT	p.I5134I	TTN_ENST00000342992.6_Silent_p.I3890I|TTN_ENST00000591111.1_Silent_p.I4817I|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4817	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAACGAAAAGATCTCCAGAC	0.383000													52	162					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157931073	157931073	+	Nonsense_Mutation	SNP	G	G	A	rs142009346	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157931073G>A	ENST00000389413.3	-	7	1148	c.1045C>T	c.(1045-1047)Cga>Tga	p.R349*	PTPRN2_ENST00000409483.1_Nonsense_Mutation_p.R311*|PTPRN2_ENST00000404321.2_Nonsense_Mutation_p.R372*|PTPRN2_ENST00000389416.4_Nonsense_Mutation_p.R332*|PTPRN2_ENST00000389418.4_Nonsense_Mutation_p.R349*	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	349						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGGCTGCCTCGAGCTACTCCA	0.672000													33	80					0	0	1	0	0
TUBBP1	92755	broad.mit.edu	37	8	30210064	30210064	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30210064G>A	ENST00000518096.1	+	0	676																											CACCGTGATCGAGTCCTACAA	0.498000													21	40					0	0	1	0	0
LIMS1	3987	broad.mit.edu	37	2	109276206	109276206	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:109276206G>T	ENST00000393310.1	+	2	309	c.142G>T	c.(142-144)Gga>Tga	p.G48*	LIMS1_ENST00000409441.1_Nonsense_Mutation_p.G85*|LIMS1_ENST00000338045.3_Nonsense_Mutation_p.G48*|LIMS1_ENST00000544547.1_Nonsense_Mutation_p.G60*|LIMS1_ENST00000332345.6_Nonsense_Mutation_p.G48*|LIMS1_ENST00000410093.1_Nonsense_Mutation_p.G52*|LIMS1_ENST00000393314.2_Nonsense_Mutation_p.G110*|LIMS1_ENST00000462817.1_3'UTR|LIMS1_ENST00000542845.1_Nonsense_Mutation_p.G110*	NM_001193488.1	NP_001180417.1	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	48	LIM zinc-binding 1.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	10						GTTCCCAGAAGGACTCTTCTA	0.577000													23	92					5.35356e-11	5.37529e-11	1	1	0
PTPRH	5794	broad.mit.edu	37	19	55699491	55699491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55699491C>T	ENST00000376350.3	-	13	2452	c.2430G>A	c.(2428-2430)agG>agA	p.R810R	PTPRH_ENST00000263434.5_Silent_p.R632R	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	810					apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TCTCATTCTTCCTGACGTGGT	0.572000													55	112					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256043	140256043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140256043C>T	ENST00000398631.2	+	1	986	c.986C>T	c.(985-987)tCc>tTc	p.S329F	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGATTCCTTCCATGGCAGGT	0.433000													27	67					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106740156	106740156	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:106740156C>T	ENST00000299045.3	+	10	1582	c.1408C>T	c.(1408-1410)Cag>Tag	p.Q470*		NM_152772.1	NP_689985.1	Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	470										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						AGCTGTCATTCAGCAGGAGCT	0.428000													10	33					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73477983	73477983	+	Missense_Mutation	SNP	G	G	A	rs34852121		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73477983G>A	ENST00000252034.7	+	29	2350	c.1951G>A	c.(1951-1953)Gga>Aga	p.G651R	ELN_ENST00000380576.5_Missense_Mutation_p.G632R|ELN_ENST00000458204.1_Missense_Mutation_p.G641R|ELN_ENST00000380575.4_Missense_Mutation_p.G622R|ELN_ENST00000320492.7_Missense_Mutation_p.G570R|ELN_ENST00000414324.1_Missense_Mutation_p.G627R|ELN_ENST00000380553.4_Missense_Mutation_p.G515R|ELN_ENST00000357036.5_Missense_Mutation_p.G656R|ELN_ENST00000429192.1_Missense_Mutation_p.G637R|ELN_ENST00000380584.4_Missense_Mutation_p.G603R|ELN_ENST00000358929.4_Missense_Mutation_p.G719R|ELN_ENST00000445912.1_Missense_Mutation_p.G651R|ELN_ENST00000380562.4_Missense_Mutation_p.G657R|ELN_ENST00000320399.6_Missense_Mutation_p.G684R	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	713	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CGGAGGACTCGGAGTCGGAGG	0.587000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						18	109					0	0	1	0	0
CPN2	1370	broad.mit.edu	37	3	194062985	194062985	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:194062985G>A	ENST00000323830.3	-	2	536	c.447C>T	c.(445-447)tcC>tcT	p.S149S	CPN2_ENST00000429275.1_Silent_p.S149S	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	149					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GCAGGTGGAGGGACTCCAGGG	0.627000													15	30					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27375502	27375502	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27375502C>T	ENST00000376087.4	-	5	840	c.675G>A	c.(673-675)agG>agA	p.R225R	ANKRD26_ENST00000436985.2_Silent_p.R225R	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	225						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						GTTTAGGTATCCTTTCTTCTT	0.264000													27	83					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136600940	136600940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136600940C>T	ENST00000531224.1	-	3	317	c.65G>A	c.(64-66)cGa>cAa	p.R22Q	BCLAF1_ENST00000527536.1_Missense_Mutation_p.R22Q|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R22Q|BCLAF1_ENST00000392348.2_Missense_Mutation_p.R22Q|BCLAF1_ENST00000530767.1_Missense_Mutation_p.R22Q|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R22Q	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	22					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGATCTTGATCGAGAACTAGA	0.323000													4	56					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85478726	85478726	+	Missense_Mutation	SNP	G	G	A	rs147369428	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85478726G>A	ENST00000394573.1	+	15	1760	c.1558G>A	c.(1558-1560)Ggc>Agc	p.G520S	SLC28A1_ENST00000537624.1_Missense_Mutation_p.G520S|SLC28A1_ENST00000537216.1_Missense_Mutation_p.G520S|SLC28A1_ENST00000538177.1_Intron|SLC28A1_ENST00000286749.3_Missense_Mutation_p.G520S	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	520					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGAGTGGGTCGGCGACAGGAA	0.622000													24	212					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081516	152081516	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152081516G>A	ENST00000368804.1	-	2	4176	c.4177C>T	c.(4177-4179)Ctt>Ttt	p.L1393F		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1393	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCCTTAAGGAATTTTCTC	0.587000													20	166					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33895456	33895456	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33895456C>T	ENST00000389232.4	+	18	2125	c.2055C>T	c.(2053-2055)gcC>gcT	p.A685A	RYR3_ENST00000415757.3_Silent_p.A685A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	685	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGGCTGGGCCTCTTCTTCAG	0.567000													61	183					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41963935	41963935	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:41963935C>T	ENST00000454645.1	-	0	660					NR_003670.1																						TCCTGATTTCCATGATATCTG	0.408000													14	135					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228560541	228560541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228560541C>T	ENST00000570156.2	+	105	25007	c.24933C>T	c.(24931-24933)ccC>ccT	p.P8311P	OBSCN_ENST00000366707.4_Silent_p.P4988P|OBSCN_ENST00000422127.1_Silent_p.P7354P	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7354					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCACGTGGCCCTGGCCAGGTG	0.657000													9	9					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767661	105767661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:105767661G>A	ENST00000374798.3	+	5	818	c.748G>A	c.(748-750)Gat>Aat	p.D250N	CYLC2_ENST00000487798.1_Missense_Mutation_p.D250N	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	250	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				TGGAAAAAAAGATGCAAACAA	0.368000													10	48					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88695234	88695234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:88695234C>T	ENST00000301011.5	+	16	2738	c.2538C>T	c.(2536-2538)gcC>gcT	p.A846A	ZC3H18_ENST00000452588.2_Silent_p.A870A	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	846						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CTCCTCCAGCCAAGCGGCCCA	0.642000													31	111					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956481	18956481	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18956481C>T	ENST00000302797.3	-	0	75				MRGPRX1_ENST00000526914.1_Intron	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1						acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						gaataagtcacctatcaaaag	0.473000													5	16					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96315551	96315551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:96315551C>T	ENST00000231368.5	+	2	1421	c.729C>T	c.(727-729)atC>atT	p.I243I	LNPEP_ENST00000395770.3_Silent_p.I229I	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	243					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		ATGGACAGATCGCCATTGTTG	0.408000													5	78					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28895627	28895627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28895627C>T	ENST00000282397.4	-	23	3398	c.3147G>A	c.(3145-3147)aaG>aaA	p.K1049K	FLT1_ENST00000543394.1_Silent_p.K72K|FLT1_ENST00000540678.1_Silent_p.K267K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1049	Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AATCGGGGTTCTTATAAATAT	0.383000													35	76					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68606139	68606139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68606139C>T	ENST00000423218.2	-	23	2955	c.2860G>A	c.(2860-2862)Gag>Aag	p.E954K	ITGA11_ENST00000315757.7_Missense_Mutation_p.E954K			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	954					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	ACGTCAGCCTCGTATTTGAGG	0.637000													7	32					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55202097	55202097	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:55202097G>A	ENST00000396834.1	+	11	1672	c.1176G>A	c.(1174-1176)acG>acA	p.T392T	IL31RA_ENST00000396836.2_Silent_p.T411T|IL31RA_ENST00000490985.1_Silent_p.T269T|IL31RA_ENST00000354961.4_Silent_p.T392T|IL31RA_ENST00000359040.5_Silent_p.T411T|IL31RA_ENST00000297015.3_Silent_p.T269T|IL31RA_ENST00000447346.2_Silent_p.T411T	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	379	Fibronectin type-III 4.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				CTCAGGCCACGAACTGGACGA	0.498000													19	38					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7582885	7582885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7582885G>A	ENST00000379802.3	+	24	5731	c.5390G>A	c.(5389-5391)aGg>aAg	p.R1797K	DSP_ENST00000418664.2_Missense_Mutation_p.R1198K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1797	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCATCTAATAGGATTCAGGAA	0.373000													28	75					0	0	1	0	0
CHRNA3	1136	broad.mit.edu	37	15	78888958	78888958	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78888958C>T	ENST00000326828.5	-	6	1890	c.1506G>A	c.(1504-1506)agG>agA	p.R502R	CHRNA3_ENST00000348639.3_Intron	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	502					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						ATGCATCTTCCCTGGCCATCA	0.493000													21	71					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594170	64594170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64594170C>T	ENST00000342711.5	-	35	4485	c.4486G>A	c.(4486-4488)Gaa>Aaa	p.E1496K		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1496					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						CCGAGGCCTTCGCTGCCCATG	0.677000													4	2					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028738	37028738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37028738C>T	ENST00000358047.3	+	1	2307	c.2255C>T	c.(2254-2256)cCa>cTa	p.P752L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	752								p.P752Q(2)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGTCTCCGCCCAGAGCCTCTT	0.622000													25	38					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70992650	70992650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70992650C>T	ENST00000354624.5	+	3	490	c.357C>T	c.(355-357)atC>atT	p.I119I	HKDC1_ENST00000395086.2_Silent_p.I119I	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	119					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						ATGAAATCATCCGCGGGAACG	0.587000													39	134					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127961109	127961109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:127961109C>T	ENST00000335247.7	-	2	147	c.17G>A	c.(16-18)aGa>aAa	p.R6K	CYP27C1_ENST00000409327.1_Missense_Mutation_p.R6K	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	6						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		AATTCTTTGTCTCAATACGCT	0.398000													24	187					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15234791	15234791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:15234791G>A	ENST00000395930.1	-	3	298	c.112C>T	c.(112-114)Ccc>Tcc	p.P38S	TEKT3_ENST00000338696.2_Missense_Mutation_p.P38S	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	38					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TTGGAGTGGGGAAAGCGGTCC	0.537000													18	33					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287591	16287591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:16287591C>T	ENST00000343518.6	-	1	346	c.295G>A	c.(295-297)Ggc>Agc	p.G99S		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	99								p.G99C(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CACCACTTGCCCATCTTGCTC	0.602000													88	396					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85525463	85525463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85525463C>T	ENST00000295887.5	+	2	608	c.185C>T	c.(184-186)cCa>cTa	p.P62L		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	62					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		CCGGAAATTCCACCATCCTCA	0.343000													38	76					0	0	1	0	0
FLAD1	80308	broad.mit.edu	37	1	154960885	154960885	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154960885C>T	ENST00000368433.1	+	2	1020	c.677C>T	c.(676-678)tCt>tTt	p.S226F	FLAD1_ENST00000315144.10_Missense_Mutation_p.S129F|FLAD1_ENST00000368432.1_Missense_Mutation_p.S129F|FLAD1_ENST00000292180.3_Missense_Mutation_p.S226F|FLAD1_ENST00000487371.1_3'UTR|FLAD1_ENST00000295530.2_5'UTR|FLAD1_ENST00000405236.2_Missense_Mutation_p.S127F|FLAD1_ENST00000368431.3_Missense_Mutation_p.S127F			Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	226					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTGCCCTCCTCTGCCCGCCTG	0.567000													29	54					0	0	1	0	0
PRPF4	9128	broad.mit.edu	37	9	116053831	116053831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116053831C>T	ENST00000374199.4	+	14	1858	c.1457C>T	c.(1456-1458)aCt>aTt	p.T486I	PRPF4_ENST00000374198.4_Missense_Mutation_p.T487I			O43172	PRP4_HUMAN	pre-mRNA processing factor 4	487						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	23						CCGCTGAAGACTCTGGCTGGC	0.522000													10	103					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49459684	49459684	+	Missense_Mutation	SNP	C	C	T	rs143814415		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49459684C>T	ENST00000374201.3	-	2	378	c.76G>A	c.(76-78)Gaa>Aaa	p.E26K	FRMPD2_ENST00000407470.4_Missense_Mutation_p.E17K|FRMPD2_ENST00000305531.3_Missense_Mutation_p.E24K	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	26	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GACAGAGCTTCACCCCTGACC	0.572000													23	53					0	0	1	0	0
CRYAA	1409	broad.mit.edu	37	21	44590729	44590729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:44590729G>A	ENST00000291554.2	+	2	384	c.292G>A	c.(292-294)Gga>Aga	p.G98R	CRYAA_ENST00000398133.1_Missense_Mutation_p.G78R|CRYAA_ENST00000398132.1_Missense_Mutation_p.G61R|CRYAA_ENST00000482775.1_3'UTR	NM_000394.2	NP_000385.1	P02489	CRYAA_HUMAN	crystallin, alpha A	98					anti-apoptosis|negative regulation of intracellular transport|protein homooligomerization|response to heat|visual perception	cytoplasm|nucleus	structural constituent of eye lens|unfolded protein binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	11						GGAGATCCACGGAAAGCACAA	0.642000													13	53					0	0	1	0	0
SBK1	388228	broad.mit.edu	37	16	28331753	28331753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28331753C>T	ENST00000341901.4	+	4	1575	c.786C>T	c.(784-786)ttC>ttT	p.F262F		NM_001024401.2	NP_001019572.1	Q52WX2	SBK1_HUMAN	SH3 domain binding kinase 1	262	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			kidney(1)|lung(3)|ovary(1)	5						CCGACGCCTTCTTCGAGGAGT	0.716000													13	27					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18657714	18657714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18657714G>A	ENST00000380548.4	+	8	1251	c.912G>A	c.(910-912)acG>acA	p.T304T	ADAMTSL1_ENST00000380566.4_Silent_p.T304T|ADAMTSL1_ENST00000276935.6_Silent_p.T304T|ADAMTSL1_ENST00000327883.7_Silent_p.T304T	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	304						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GGAGGGAGACGGATTTCTTTC	0.463000													7	36					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086734	92086734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92086734C>T	ENST00000298047.6	+	1	1473	c.1456C>T	c.(1456-1458)Cca>Tca	p.P486S	FAT3_ENST00000525166.1_Missense_Mutation_p.P336S|FAT3_ENST00000409404.2_Missense_Mutation_p.P486S|FAT3_ENST00000541502.1_Missense_Mutation_p.P486S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	486	Cadherin 5.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAAAGTGTCCCAGTGGGAAC	0.413000										TCGA Ovarian(4;0.039)			6	52					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28273976	28273976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28273976G>A	ENST00000305242.5	-	4	639	c.547C>T	c.(547-549)Ctc>Ttc	p.L183F	ARMC4_ENST00000239715.3_Missense_Mutation_p.L40F	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	183							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GAATGATTGAGGAGGTGCAGA	0.373000													5	22					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264286	155264286	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155264286C>T	ENST00000392414.3	-	6	972	c.859G>A	c.(859-861)Gaa>Aaa	p.E287K	PKLR_ENST00000342741.4_Missense_Mutation_p.E318K	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	318			F -> V (in PKRD).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	TTCACGCCTTCGTGGTTCTCA	0.582000													22	62					0	0	1	0	0
PMVK	10654	broad.mit.edu	37	1	154897656	154897656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154897656G>A	ENST00000368467.3	-	5	833	c.528C>T	c.(526-528)cgC>cgT	p.R176R		NM_006556.3	NP_006547.1	Q15126	PMVK_HUMAN	phosphomevalonate kinase	176					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCTCCTCCAGGCGCTGTTCAA	0.547000													54	236					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921522	24921522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24921522G>A	ENST00000329468.2	+	1	982	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GGTGCAGATCGAAGGGGAGGA	0.617000													15	33					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75210016	75210016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:75210016C>T	ENST00000413679.2	+	17	2362	c.2059C>T	c.(2059-2061)Ctg>Ttg	p.L687L	SEC14L1_ENST00000430767.4_Silent_p.L687L|SEC14L1_ENST00000436233.4_Silent_p.L687L|SEC14L1_ENST00000443798.4_Silent_p.L687L|SEC14L1_ENST00000585618.1_Silent_p.L687L|SEC14L1_ENST00000431431.2_Silent_p.L653L|SEC14L1_ENST00000591437.1_Silent_p.L653L|SEC14L1_ENST00000392476.2_Silent_p.L687L	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	687					transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						CATGACGAGCCTGGAGTCCAG	0.667000													13	148					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778337	31778337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31778337C>T	ENST00000375654.4	-	2	1602	c.1413G>A	c.(1411-1413)agG>agA	p.R471R	HSPA1L_ENST00000417199.3_Silent_p.R471R	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	471					response to unfolded protein		ATP binding	p.R471R(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						GAGGAACTCCCCTGGGTGCTG	0.557000													43	104					0	0	1	0	0
ZDHHC22	283576	broad.mit.edu	37	14	77600103	77600103	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77600103C>T	ENST00000319374.4	-	3	917	c.715G>A	c.(715-717)Gga>Aga	p.G239R	RP11-463C8.4_ENST00000557752.1_Intron	NM_174976.2	NP_777636.2	Q8N966	ZDH22_HUMAN	zinc finger, DHHC-type containing 22	239						integral to membrane	acyltransferase activity|zinc ion binding			kidney(1)|lung(1)|urinary_tract(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		CACCTCTTTCCGAAGACCTCT	0.602000													18	34					0	0	1	0	0
CIB3	117286	broad.mit.edu	37	19	16275561	16275561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16275561C>T	ENST00000269878.4	-	5	559	c.510G>A	c.(508-510)caG>caA	p.Q170Q	CIB3_ENST00000541493.1_5'UTR|CIB3_ENST00000379859.3_Silent_p.Q121Q	NM_054113.2	NP_473454.1	Q96Q77	CIB3_HUMAN	calcium and integrin binding family member 3	170	EF-hand 3.						calcium ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16						GGATCATGTTCTGGAAATCTT	0.587000													10	53					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10470832	10470832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10470832G>A	ENST00000382483.3	-	4	999	c.776C>T	c.(775-777)cCg>cTg	p.P259L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	259					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GATCACACTCGGCTTGGTCTT	0.602000													29	59					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158725176	158725176	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158725176A>T	ENST00000368144.2	+	1	667	c.571A>T	c.(571-573)Att>Ttt	p.I191F		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					GATTGCATGGATTTCCACCTT	0.483000													35	70					0	0	1	0	0
ZNF18	7566	broad.mit.edu	37	17	11881712	11881712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11881712G>A	ENST00000322748.3	-	9	1816	c.1212C>T	c.(1210-1212)gcC>gcT	p.A404A	ZNF18_ENST00000580613.1_Intron|ZNF18_ENST00000454073.3_Silent_p.A403A|ZNF18_ENST00000580306.1_Silent_p.A404A	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	404					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		GGAGCTTCTGGGCCATGGGGG	0.507000													6	64					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103109210	103109210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:103109210G>A	ENST00000374902.4	-	3	835	c.659C>T	c.(658-660)tCt>tTt	p.S220F	TEX10_ENST00000537512.1_Missense_Mutation_p.S155F|TEX10_ENST00000535814.1_Missense_Mutation_p.S223F	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	220						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CCATTGCTGAGAAGTGAGTCT	0.438000													16	79					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050262	42050262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42050262G>A	ENST00000372584.1	-	3	1221	c.207C>T	c.(205-207)ggC>ggT	p.G69G	HIVEP3_ENST00000429157.2_Silent_p.G69G|HIVEP3_ENST00000372583.1_Silent_p.G69G|HIVEP3_ENST00000247584.5_Silent_p.G69G	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	69					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding	p.G69G(1)		NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TCTCCTGAGAGCCTTCCCTAA	0.637000													70	162					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166896371	166896371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:166896371C>T	ENST00000271417.3	-	7	982	c.927G>A	c.(925-927)atG>atA	p.M309I	ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000525740.1_Missense_Mutation_p.M182I|ILDR2_ENST00000526687.1_Missense_Mutation_p.M201I|ILDR2_ENST00000469934.2_Missense_Mutation_p.M309I|ILDR2_ENST00000529071.1_Missense_Mutation_p.M290I|ILDR2_ENST00000528703.1_Missense_Mutation_p.M250I	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	309						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						ACAGGACCTTCATGGAGTCTC	0.463000													62	107					0	0	1	0	0
MATN3	4148	broad.mit.edu	37	2	20205896	20205896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:20205896G>A	ENST00000407540.3	-	2	461	c.399C>T	c.(397-399)atC>atT	p.I133I	MATN3_ENST00000421259.2_Silent_p.I133I	NM_002381.4	NP_002372.1	O15232	MATN3_HUMAN	matrilin 3	133	VWFA.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTGGAACTCGATCTTCACAG	0.547000													15	25					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131831414	131831414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131831414C>T	ENST00000359827.3	-	28	5872	c.4910G>A	c.(4909-4911)cGg>cAg	p.R1637Q	PLXNA4_ENST00000321063.4_Missense_Mutation_p.R1637Q			Q9HCM2	PLXA4_HUMAN	plexin A4	1637						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CATAGGTGTCCGTGAGCGGAG	0.602000													62	180					0	0	1	0	0
HGFAC	3083	broad.mit.edu	37	4	3445789	3445789	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3445789G>A	ENST00000382774.3	+	5	614	c.499G>A	c.(499-501)Ggc>Agc	p.G167S	HGFAC_ENST00000511533.1_Missense_Mutation_p.G167S	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	167	EGF-like 1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CTGTGCCTCCGGCCCCTGCCT	0.662000													27	50					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140011718	140011718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140011718G>A	ENST00000302014.6	-	2	1480	c.851C>T	c.(850-852)tCg>tTg	p.S284L	CD14_ENST00000401743.2_Missense_Mutation_p.S284L	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	284					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCAGCGAACGACAGATTGAG	0.617000													20	65					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30680738	30680738	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30680738G>A	ENST00000376406.3	-	5	1628	c.981C>T	c.(979-981)atC>atT	p.I327I	MDC1_ENST00000376405.2_Silent_p.I327I|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	327	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TGTCGCTGTCGATGAAGCCAA	0.532000								Other conserved DNA damage response genes					18	169					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151835361	151835361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:151835361C>T	ENST00000535741.1	-	9	1620	c.1147G>A	c.(1147-1149)Ggc>Agc	p.G383S	LRBA_ENST00000510413.1_Missense_Mutation_p.G383S|LRBA_ENST00000507224.1_Missense_Mutation_p.G383S|LRBA_ENST00000357115.3_Missense_Mutation_p.G383S			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	383						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TATCCCAGGCCCAACTGATAA	0.393000													36	156					0	0	1	0	0
LCE3D	84648	broad.mit.edu	37	1	152552347	152552347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152552347G>A	ENST00000368787.3	-	2	122	c.66C>T	c.(64-66)ccC>ccT	p.P22P		NM_032563.1	NP_115952.1	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	22					keratinization					breast(1)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|stomach(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GGCTCTTTGGGGGACACTTGG	0.607000													24	151					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189587118	189587118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189587118C>T	ENST00000264731.3	+	9	1224	c.1135C>T	c.(1135-1137)Cgt>Tgt	p.R379C	TP63_ENST00000392461.3_Missense_Mutation_p.R285C|TP63_ENST00000418709.2_Missense_Mutation_p.R379C|TP63_ENST00000449992.1_Missense_Mutation_p.R200C|TP63_ENST00000437221.1_Missense_Mutation_p.R285C|TP63_ENST00000320472.5_Missense_Mutation_p.R379C|TP63_ENST00000392463.2_Missense_Mutation_p.R285C|TP63_ENST00000392460.3_Missense_Mutation_p.R379C|TP63_ENST00000456148.1_Missense_Mutation_p.R281C|TP63_ENST00000382063.4_Missense_Mutation_p.R294C|TP63_ENST00000354600.5_Missense_Mutation_p.R285C|TP63_ENST00000440651.2_Missense_Mutation_p.R375C	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	379	Interaction with HIPK2.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R379C(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCAGCGTTTCGTCAGAACAC	0.363000										HNSCC(45;0.13)			13	53					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38860616	38860616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38860616C>T	ENST00000409235.3	+	27	3140	c.3025C>T	c.(3025-3027)Ctc>Ttc	p.L1009F	CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Missense_Mutation_p.L969F	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	1009					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						TTGCAGGTGGCTCTGTCTGGA	0.512000													68	154					0	0	1	0	0
TMEM19	55266	broad.mit.edu	37	12	72092798	72092798	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72092798C>T	ENST00000266673.5	+	5	1350	c.756C>T	c.(754-756)gcC>gcT	p.A252A	TMEM19_ENST00000549735.1_Silent_p.A252A	NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	252						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		ACATTTCTGCCCCGCAGTGGC	0.453000													46	78					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175087870	175087870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175087870G>A	ENST00000239462.4	+	11	2673	c.2560G>A	c.(2560-2562)Ggc>Agc	p.G854S		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	854	Fibronectin type-III 7.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGTCCTGACGGGCCTGAGGCC	0.607000													28	91					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66802194	66802194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66802194G>A	ENST00000393946.2	+	6	1275	c.113G>A	c.(112-114)aGc>aAc	p.S38N	SYT12_ENST00000526281.1_Intron|SYT12_ENST00000527043.1_Missense_Mutation_p.S38N|SYT12_ENST00000525457.1_Missense_Mutation_p.S38N			Q8IV01	SYT12_HUMAN	synaptotagmin XII	38						cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						GCAGCTGTGAGCCTGTGGAAG	0.632000													22	61					0	0	1	0	0
ETV5	2119	broad.mit.edu	37	3	185766484	185766484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185766484G>A	ENST00000306376.5	-	13	1723	c.1477C>T	c.(1477-1479)Ctc>Ttc	p.L493F	ETV5_ENST00000480706.1_5'UTR|ETV5_ENST00000434744.1_Missense_Mutation_p.L493F|ETV5_ENST00000537818.1_Missense_Mutation_p.L535F	NM_004454.2	NP_004445.1	P41161	ETV5_HUMAN	ets variant 5	493					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|cervix(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	28	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			ATGTCCAGGAGGTAAGCGGGG	0.602000			T	"""TMPRSS2, SCL45A3"""	Prostate								22	48					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52827873	52827873	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52827873G>A	ENST00000252245.5	-	1	436	c.216C>T	c.(214-216)tcC>tcT	p.S72S		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	72	Gly-rich.|Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		ACCCATTGATGGAGACCCGCT	0.622000													34	67					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631943	32631943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32631943G>A	ENST00000242310.4	-	1	3724	c.3635C>T	c.(3634-3636)gCc>gTc	p.A1212V		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1212					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GCGCACATAGGCATCAATGAC	0.448000													61	94					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21548335	21548335	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21548335C>T	ENST00000415912.2	-	18	2118	c.1992_splice	c.e18-1	p.A665_splice	ECE1_ENST00000436918.2_Intron|ECE1_ENST00000264205.6_Splice_Site_p.A678_splice|ECE1_ENST00000374893.6_Splice_Site_p.A681_splice|ECE1_ENST00000357071.4_Splice_Site_p.A669_splice	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	681					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TTCTGGTAAGCCTGGGAGGAG	0.597000													54	100					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803905	23803905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:23803905C>T	ENST00000264867.2	-	11	2202	c.2083G>A	c.(2083-2085)Gac>Aac	p.D695N	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	695	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TCAAAACGGTCCCTCAGTTCT	0.458000													13	119					0	0	1	0	0
SLC45A3	85414	broad.mit.edu	37	1	205632659	205632659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205632659G>A	ENST00000367145.3	-	3	555	c.260C>T	c.(259-261)cCc>cTc	p.P87L		NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	87					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			CCAGATGAAGGGCCGGCGGCG	0.662000			T	"""ETV1, ETV5, ELK4, ERG"""	prostate								19	44					0	0	1	0	0
LRRC15	131578	broad.mit.edu	37	3	194080213	194080213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:194080213G>A	ENST00000347624.3	-	2	1645	c.1560C>T	c.(1558-1560)acC>acT	p.T520T	LRRC15_ENST00000428839.1_Silent_p.T526T|LRRC15_ENST00000439944.2_Silent_p.T526T	NM_130830.4	NP_570843.2	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15	520						integral to membrane				biliary_tract(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(20)|ovary(4)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TGACCTGAATGGTAGTCAGAT	0.572000													9	31					0	0	1	0	0
TMCC3	57458	broad.mit.edu	37	12	94975597	94975597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:94975597C>T	ENST00000261226.4	-	2	927	c.796G>A	c.(796-798)Gac>Aac	p.D266N	TMCC3_ENST00000551457.1_Missense_Mutation_p.D235N	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	266						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						CCGTTACTGTCGGCCGAGCCT	0.597000													32	98					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39613254	39613254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39613254G>A	ENST00000265708.4	-	16	1893	c.1790C>T	c.(1789-1791)tCa>tTa	p.S597L	ADAM2_ENST00000379853.2_Missense_Mutation_p.S441L|ADAM2_ENST00000347580.4_Missense_Mutation_p.S578L|ADAM2_ENST00000521880.1_Intron	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	597	Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TACCTTATTTGAACCACAAGA	0.398000													12	28					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907650	12907650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12907650C>T	ENST00000317869.6	-	2	718	c.493G>A	c.(493-495)Gga>Aga	p.G165R		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						CCCCGCTTTCCACTCTTAGAA	0.488000													92	478					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541302	40541302	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40541302A>G	ENST00000434248.1	-	5	1529	c.1464T>C	c.(1462-1464)ctT>ctC	p.L488L	ZNF780B_ENST00000221355.6_Silent_p.L340L	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGTCGAGCAAGCTGTGTCA	0.403000													32	103					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57967220	57967220	+	Missense_Mutation	SNP	G	G	A	rs146505887	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57967220G>A	ENST00000574161.1	+	12	1377	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	GCOM1_ENST00000380560.2_Missense_Mutation_p.E351K|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000587652.1_Missense_Mutation_p.E420K|GCOM1_ENST00000572390.1_Missense_Mutation_p.E392K|GCOM1_ENST00000380561.2_Missense_Mutation_p.E361K|MYZAP_ENST00000380565.4_Missense_Mutation_p.E392K|GCOM1_ENST00000396180.1_Missense_Mutation_p.E389K|GCOM1_ENST00000380569.2_Missense_Mutation_p.E420K|GCOM1_ENST00000380568.3_Missense_Mutation_p.E420K|MYZAP_ENST00000267853.5_Missense_Mutation_p.E420K	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		420					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GGCCAAGACTGAAGTGGAAAC	0.378000													7	67					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158139206	158139206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:158139206G>A	ENST00000313708.6	-	14	1787	c.1505C>T	c.(1504-1506)tCc>tTc	p.S502F	EBF1_ENST00000380654.4_Missense_Mutation_p.S471F|EBF1_ENST00000517373.1_Intron|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	502	Pro/Ser/Thr-rich.				multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAAGGTGGGGGAGCCGCCCAA	0.567000			T	HMGA2	lipoma								4	27					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45708297	45708297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45708297G>A	ENST00000291582.5	+	5	735	c.608G>A	c.(607-609)cGa>cAa	p.R203Q		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	203	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		CCGGGAGCCCGAGGGGCCGTG	0.632000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				33	59					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95718849	95718849	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95718849C>T	ENST00000480546.1	-	0	2448					NR_002319.2																						ATCTTCTCTTCCTCAGTCATA	0.532000													18	38					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44624560	44624560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:44624560G>A	ENST00000332990.5	-	6	730	c.714C>T	c.(712-714)atC>atT	p.I238I		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	238						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						ACCAGCCAATGATGACCAGGG	0.453000													13	37					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398577	89398577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89398577G>A	ENST00000439576.2	+	12	3135	c.2761G>A	c.(2761-2763)Ggg>Agg	p.G921R	ACAN_ENST00000352105.7_Missense_Mutation_p.G921R|ACAN_ENST00000559004.1_Missense_Mutation_p.G921R|ACAN_ENST00000561243.1_Missense_Mutation_p.G921R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	921					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			ACTACCCTCAGGGGATGAAGA	0.587000													29	33					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52732463	52732463	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:52732463G>C	ENST00000287727.3	+	6	2587	c.2415G>C	c.(2413-2415)gtG>gtC	p.V805V	ZFYVE9_ENST00000371591.1_Silent_p.V805V|ZFYVE9_ENST00000357206.2_Intron	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	805	SBD.				endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						CTCCCACTGTGATGGTACCTG	0.507000													24	57					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226490	23226490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23226490C>T	ENST00000300061.2	+	13	1793	c.1650C>T	c.(1648-1650)atC>atT	p.I550I		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	550					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TCGAGATCATCGAGGTCTTCT	0.557000													15	64					0	0	1	0	0
SLC25A37	51312	broad.mit.edu	37	8	23429132	23429132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:23429132C>T	ENST00000519973.1	+	4	979	c.781C>T	c.(781-783)Ctt>Ttt	p.L261F		NM_016612.2	NP_057696.2	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 37	261					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		CTGTAAGACCCTTCTGAACAC	0.677000													10	22					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	92027859	92027859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92027859C>T	ENST00000265742.3	+	20	3242	c.2866C>T	c.(2866-2868)Cct>Tct	p.P956S		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	956							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATCTAGTGATCCTGACTCAGC	0.493000													46	97					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561352	9561352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9561352C>T	ENST00000378429.3	-	5	976	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	PAK7_ENST00000378423.1_Missense_Mutation_p.E144K|PAK7_ENST00000353224.5_Missense_Mutation_p.E144K	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	144	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity	p.E144K(1)		NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CTGTACTTTTCGGTCGTGTAG	0.512000													41	190					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975411	20975411	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20975411G>A	ENST00000261383.3	-	53	9794	c.9795C>T	c.(9793-9795)tcC>tcT	p.S3265S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3265	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCACTTTGGAGGAGGACAGAA	0.468000													43	135					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32065044	32065044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32065044G>A	ENST00000375244.3	-	3	787	c.586C>T	c.(586-588)Cgc>Tgc	p.R196C	TNXB_ENST00000375247.2_Missense_Mutation_p.R196C|TNXB_ENST00000479795.1_Missense_Mutation_p.R196C			P22105	TENX_HUMAN	tenascin XB	196	EGF-like 2.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CGGACACAGCGACCCTGATCA	0.667000													5	15					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36166626	36166626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36166626C>T	ENST00000303965.4	-	11	2572	c.2083G>A	c.(2083-2085)Gaa>Aaa	p.E695K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	695	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTGTTGGATTCATTGAACCAA	0.433000													6	79					0	0	1	0	0
C7orf26	79034	broad.mit.edu	37	7	6641744	6641744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:6641744C>T	ENST00000344417.5	+	5	1388	c.1121C>T	c.(1120-1122)aCc>aTc	p.T374I	C7orf26_ENST00000359073.5_Missense_Mutation_p.T277I|C7orf26_ENST00000472693.1_3'UTR	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	374										endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		GACCTGAGAACCTTGTGCTCC	0.502000											OREG0017863	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	67					0	0	1	0	0
TTLL11	158135	broad.mit.edu	37	9	124752002	124752002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:124752002G>A	ENST00000321582.5	-	4	1198	c.1011C>T	c.(1009-1011)atC>atT	p.I337I	TTLL11_ENST00000373776.3_Silent_p.I337I|TTLL11_ENST00000474723.1_5'UTR	NM_001139442.1	NP_001132914.1	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	337	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity	p.I337I(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						CAGGTTTCACGATAAAAGTGG	0.532000													44	172					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123163094	123163094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123163094C>T	ENST00000349780.4	-	35	5556	c.5377G>A	c.(5377-5379)Gcc>Acc	p.A1793T	CDK5RAP2_ENST00000480467.1_5'UTR|CDK5RAP2_ENST00000360190.4_Missense_Mutation_p.A1714T|CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.A1752T|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.A1761T	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1793	Interaction with PCNT and AKAP9.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						CGCCTGTAGGCCTCTTCCAGG	0.587000													15	57					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42729691	42729691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42729691C>T	ENST00000287777.4	+	2	1310	c.1210C>T	c.(1210-1212)Ctc>Ttc	p.L404F		NM_152393.2	NP_689606.2			kelch-like family member 40																		GCCCCGCTGCCTCTTTGGCCT	0.642000													21	55					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249706	52249706	+	Missense_Mutation	SNP	G	G	A	rs146075164		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52249706G>A	ENST00000595042.1	-	3	683	c.542C>T	c.(541-543)tCg>tTg	p.S181L	FPR1_ENST00000304748.4_Missense_Mutation_p.S181L	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	181					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity	p.S181L(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GGTCCAGGGCGAAAAGTTAAA	0.527000													29	75					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158272456	158272456	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158272456C>A	ENST00000264192.3	-	8	934	c.813G>T	c.(811-813)agG>agT	p.R271S	CYTIP_ENST00000540637.1_Missense_Mutation_p.R165S	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	271	Ser-rich.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						TGAAGGCACCCCTGCTGGAGT	0.532000													28	57					1.75199e-13	1.76061e-13	1	1	0
FLNB	2317	broad.mit.edu	37	3	58155415	58155415	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58155415C>T	ENST00000295956.4	+	45	7681	c.7516C>T	c.(7516-7518)Ccc>Tcc	p.P2506S	FLNB_ENST00000493452.1_Missense_Mutation_p.P2313S|FLNB_ENST00000490882.1_Missense_Mutation_p.P2537S|FLNB_ENST00000429972.2_Missense_Mutation_p.P2495S|FLNB_ENST00000419752.2_Missense_Mutation_p.P2326S|FLNB_ENST00000348383.5_Missense_Mutation_p.P2465S|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000358537.3_Missense_Mutation_p.P2482S|FLNB-AS1_ENST00000488720.1_RNA|FLNB_ENST00000484981.1_3'UTR	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2506	Hinge 2 (By similarity).|Interaction with INPPL1.|Self-association site, tail (By similarity).				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TAGCGCCATTCCCAAGGCATC	0.587000													49	101					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34180243	34180243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:34180243C>T	ENST00000262622.3	+	2	834	c.76C>T	c.(76-78)Ctc>Ttc	p.L26F	CHST8_ENST00000434302.1_Missense_Mutation_p.L26F|CHST8_ENST00000604556.1_Missense_Mutation_p.L26F|CHST8_ENST00000438847.2_Missense_Mutation_p.L26F	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	26					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					TGCAGGCCTCCTCCTCTTCAT	0.642000													24	119					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	618098	618098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:618098C>T	ENST00000358353.3	-	15	2296	c.1974G>A	c.(1972-1974)tcG>tcA	p.S658S	CDHR5_ENST00000349570.7_Silent_p.S464S|CDHR5_ENST00000397542.2_Silent_p.S658S			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	658					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GCTTGTCCTCCGAGGGGCCGC	0.652000													4	42					0	0	1	0	0
FOXJ1	2302	broad.mit.edu	37	17	74134004	74134004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74134004G>A	ENST00000322957.6	-	3	1050	c.696C>T	c.(694-696)ccC>ccT	p.P232P		NM_001454.3	NP_001445.2	Q92949	FOXJ1_HUMAN	forkhead box J1	232					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|liver(1)|pancreas(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(166;0.187)			GGACAGCGCTGGGCTCCTGCG	0.726000													3	7					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76756929	76756929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76756929G>A	ENST00000536229.3	+	3	3604	c.2895G>A	c.(2893-2895)gcG>gcA	p.A965A	SALL3_ENST00000575389.2_Silent_p.A1098A|SALL3_ENST00000537592.2_Silent_p.A1170A			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		ACGCCCCCGCGAGACGCGGCC	0.627000													10	24					0	0	1	0	0
IGLV3-9	28804	broad.mit.edu	37	22	23162132	23162132	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23162132G>A	ENST00000390316.2	+	0	340																											GGCCCTCTGGGATCCCTGAGC	0.572000													28	56					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57843625	57843625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57843625C>T	ENST00000309668.2	+	2	1006	c.879C>T	c.(877-879)tcC>tcT	p.S293S	INHBC_ENST00000550133.1_Intron	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	293					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						TTGCTGCCTCCTTTCACACTG	0.602000													6	67					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17235032	17235032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:17235032G>A	ENST00000261381.6	-	7	1649	c.1565C>T	c.(1564-1566)tCc>tTc	p.S522F		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	522					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAGGGTGTAGGAGTAGAACTG	0.478000													36	313					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166246007	166246007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166246007G>A	ENST00000357398.3	+	27	5981	c.5691G>A	c.(5689-5691)acG>acA	p.T1897T	SCN2A_ENST00000375437.2_Silent_p.T1897T|SCN2A_ENST00000375427.2_Silent_p.T1897T|SCN2A_ENST00000283256.6_Silent_p.T1897T			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1897					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	AGCCCATTACGACCACGTTGA	0.448000													28	53					0	0	1	0	0
TFCP2L1	29842	broad.mit.edu	37	2	122007186	122007186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:122007186C>T	ENST00000263707.5	-	3	349	c.252G>A	c.(250-252)aaG>aaA	p.K84K		NM_014553.2	NP_055368.1	Q9NZI6	TF2L1_HUMAN	transcription factor CP2-like 1	84					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)|pancreas(2)|skin(1)|stomach(1)	22	Renal(3;0.01)					AGTCTCCCAGCTTCCGATTCT	0.458000													30	75					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8182167	8182167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8182167C>T	ENST00000600128.1	-	28	3886	c.3472G>A	c.(3472-3474)Gaa>Aaa	p.E1158K	FBN3_ENST00000601739.1_Missense_Mutation_p.E1158K|FBN3_ENST00000270509.2_Missense_Mutation_p.E1158K			Q75N90	FBN3_HUMAN	fibrillin 3	1158	EGF-like 16; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ACCCGGCATTCGTTGATGTCT	0.642000													7	29					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11218112	11218112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11218112G>A	ENST00000558518.1	+	6	1049	c.862G>A	c.(862-864)Gaa>Aaa	p.E288K	LDLR_ENST00000545707.1_Missense_Mutation_p.E161K|LDLR_ENST00000558013.1_Missense_Mutation_p.E288K|LDLR_ENST00000535915.1_Missense_Mutation_p.E247K|LDLR_ENST00000455727.2_Missense_Mutation_p.E120K|LDLR_ENST00000557933.1_Missense_Mutation_p.E288K	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	288	LDL-receptor class A 7.		E -> K (in FH; German patient).		cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	TCACAGCGGCGAATGCATCAC	0.562000													11	52					0	0	1	0	0
HEXB	3074	broad.mit.edu	37	5	73981299	73981299	+	Missense_Mutation	SNP	C	C	T	rs147155126	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:73981299C>T	ENST00000261416.7	+	1	331	c.214C>T	c.(214-216)Ctc>Ttc	p.L72F	HEXB_ENST00000511181.1_Intron	NM_000521.3	NP_000512.1	P07686	HEXB_HUMAN	hexosaminidase B (beta polypeptide)	72					cell death	lysosome	cation binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(3)|large_intestine(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.72e-57)		CCTGCTGCATCTCGCCCCGGA	0.706000													4	37					0	0	1	0	0
ANKS3	124401	broad.mit.edu	37	16	4776692	4776692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4776692G>A	ENST00000304283.4	-	5	753	c.459C>T	c.(457-459)ttC>ttT	p.F153F	ANKS3_ENST00000450067.2_Intron|ANKS3_ENST00000592711.1_Intron|ANKS3_ENST00000446014.2_Silent_p.F24F|ANKS3_ENST00000585773.1_Silent_p.F80F	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	153										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						TGTCCAAGAGGAACCTGACCA	0.552000													27	44					0	0	1	0	0
RBM28	55131	broad.mit.edu	37	7	127950857	127950857	+	Missense_Mutation	SNP	T	T	C	rs148028531	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127950857T>C	ENST00000223073.1	-	19	2387	c.2273A>G	c.(2272-2274)gAt>gGt	p.D758G	RBM28_ENST00000481788.1_5'UTR|RBM28_ENST00000415472.2_Missense_Mutation_p.D617G	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	758					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						TCATCAACTATCAAACCATTT	0.502000													10	191					0	0	1	0	0
PLBD2	196463	broad.mit.edu	37	12	113825664	113825664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113825664C>T	ENST00000280800.3	+	11	1586	c.1555C>T	c.(1555-1557)Ccc>Tcc	p.P519S	PLBD2_ENST00000545182.2_Missense_Mutation_p.P487S	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	519					lipid catabolic process	lysosomal lumen	hydrolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						TGGCTCCTACCCCTTCCAGGC	0.637000													60	219					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157771953	157771953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157771953C>T	ENST00000358292.3	-	5	689	c.638G>A	c.(637-639)aGg>aAg	p.R213K	FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.R213K|FCRL1_ENST00000368176.3_Missense_Mutation_p.R213K	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	213	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCTGGGAGCCCTGAGCATGAG	0.567000													28	44					0	0	1	0	0
SGCA	6442	broad.mit.edu	37	17	48245758	48245758	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48245758G>A	ENST00000262018.3	+	5	445	c.409G>A	c.(409-411)Gag>Aag	p.E137K	SGCA_ENST00000344627.6_Missense_Mutation_p.E137K|SGCA_ENST00000451235.2_Missense_Mutation_p.E35K|SGCA_ENST00000543315.1_Missense_Mutation_p.E137K|SGCA_ENST00000513942.1_3'UTR	NM_000023.2	NP_000014.1	Q16586	SGCA_HUMAN	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	137			E -> G (in LGMD2D; associated with P-G-A- Q-P-136 ins; dbSNP:rs28933694).|E -> K (in LGMD2D).		muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(2)|skin(1)	14						ATACCAAGCCGAGTTCCTGGT	0.677000													3	8					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113740500	113740500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113740500C>T	ENST00000397030.1	+	21	2446	c.2409C>T	c.(2407-2409)tcC>tcT	p.S803S	MCF2L_ENST00000535094.2_Silent_p.S770S|MCF2L_ENST00000442652.2_Silent_p.S800S|MCF2L_ENST00000375608.3_Silent_p.S800S|MCF2L_ENST00000434480.2_Silent_p.S776S|MCF2L_ENST00000375597.4_Silent_p.S768S|MCF2L_ENST00000421756.1_Silent_p.S774S|MCF2L_ENST00000375604.2_Silent_p.S827S|MCF2L_ENST00000423482.2_Silent_p.S768S|MCF2L_ENST00000375601.3_Silent_p.S774S			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	800	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CGCTGAGCTCCATCCTGGGCA	0.637000													15	32					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28764623	28764623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:28764623C>T	ENST00000422425.2	+	13	901	c.857C>T	c.(856-858)tCc>tTc	p.S286F	PLB1_ENST00000327757.5_Missense_Mutation_p.S275F	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	275	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GAGCAGGAGTCCTTCACCGTG	0.592000													18	38					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47279210	47279210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47279210G>A	ENST00000271153.4	+	5	588	c.552G>A	c.(550-552)gtG>gtA	p.V184V	CYP4B1_ENST00000371923.4_Silent_p.V184V|CYP4B1_ENST00000371919.4_Silent_p.V169V|CYP4B1_ENST00000452782.2_Silent_p.V21V			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	184					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TCTGCGATGTGGGTCACATGG	0.582000													19	67					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10265703	10265703	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10265703C>T	ENST00000418404.3	-	3	485	c.322G>A	c.(322-324)Gag>Aag	p.E108K	MYH13_ENST00000570743.1_Missense_Mutation_p.E108K|MYH13_ENST00000252172.4_Missense_Mutation_p.E108K			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	108	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GCATAGCGCTCTTTGAGGTTG	0.443000													60	81					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089883	9089883	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9089883C>T	ENST00000397910.4	-	1	2135	c.1932G>A	c.(1930-1932)acG>acA	p.T644T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	644	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGACACCGTTCGTGGCCAGAG	0.567000													34	94					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39425979	39425979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39425979G>A	ENST00000280481.7	+	11	7115	c.6899G>A	c.(6898-6900)gGa>gAa	p.G2300E		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2300	Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCCACCTCTGGAGAAGACTAC	0.527000													17	43					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123019089	123019089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123019089C>T	ENST00000462833.1	-	15	3990	c.2778G>A	c.(2776-2778)caG>caA	p.Q926Q	ADCY5_ENST00000309879.5_Silent_p.Q576Q|ADCY5_ENST00000491190.1_Silent_p.Q559Q	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	926					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TGCAGCTGATCTGCAGGAACA	0.637000													13	28					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507303	74507303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:74507303C>T	ENST00000354431.4	-	7	1503	c.1312G>A	c.(1312-1314)Gaa>Aaa	p.E438K	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.E438K	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	438								p.E438K(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						CTTACTTTTTCTTTATGGTAT	0.343000													47	107					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46653509	46653509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46653509C>T	ENST00000253255.5	-	1	5710	c.5711G>A	c.(5710-5712)aGc>aAc	p.S1904N		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1904					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CAGCCAATTGCTTTCTTGAAG	0.398000													34	89					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74274418	74274418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74274418C>T	ENST00000295897.4	+	4	467	c.378C>T	c.(376-378)ttC>ttT	p.F126F	ALB_ENST00000415165.2_Intron|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000401494.3_Intron|ALB_ENST00000509063.1_Silent_p.F126F|ALB_ENST00000503124.1_Intron	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	126	Albumin 1.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	ATGAATGCTTCTTGCAACACA	0.423000													20	36					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48288033	48288033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48288033C>T	ENST00000435803.1	+	14	1881	c.1857C>T	c.(1855-1857)gtC>gtT	p.V619V		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	619					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ACCAGCTTGTCTCCACAGTGT	0.443000													65	124					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271747	59271747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59271747G>A	ENST00000313253.1	+	1	699	c.699G>A	c.(697-699)agG>agA	p.R233R		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						GAGGGGGCAGGAGGAAAGCCA	0.552000													81	166					0	0	1	0	0
GBP1P1	400759	broad.mit.edu	37	1	89886716	89886716	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89886716G>A	ENST00000513638.1	+	0	494					NR_003133.2																						AATAGCATAGGAACCATTAAC	0.522000													21	65					0	0	1	0	0
ABCA11P	79963	broad.mit.edu	37	4	420538	420538	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:420538G>A	ENST00000451020.2	-	0	500					NR_002451.2																						TTGTTGAAAAGCAACTTTCTT	0.393000													16	29					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174630	51174630	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51174630C>T	ENST00000440970.1	-	2	1643	c.1212G>A	c.(1210-1212)gaG>gaA	p.E404E	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.E501E	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	501					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GAGGGTATTTCTCTTTGTGGC	0.517000													30	87					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44560392	44560392	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44560392C>T	ENST00000289547.4	-	14	3163	c.3108G>A	c.(3106-3108)gtG>gtA	p.V1036V	NPC1L1_ENST00000381160.3_Silent_p.V1036V|NPC1L1_ENST00000546276.1_Silent_p.V990V	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1036					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AAGTCAAGTTCACAGAGGTGC	0.577000													24	88					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16000416	16000416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16000416G>A	ENST00000221700.5	-	7	830	c.735C>T	c.(733-735)ttC>ttT	p.F245F	CYP4F2_ENST00000592328.1_Silent_p.F245F|CYP4F2_ENST00000011989.7_Silent_p.F96F	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	245					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATAATACAGGAAGTCAATAT	0.552000													70	150					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32378891	32378891	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32378891C>T	ENST00000375200.1	+	15	2498	c.2133C>T	c.(2131-2133)ttC>ttT	p.F711F	RP4-553F4.6_ENST00000423074.1_RNA|ZNF341_ENST00000342427.2_Silent_p.F704F|RP4-553F4.6_ENST00000443171.1_RNA|RP4-553F4.6_ENST00000439444.1_RNA			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	711					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						ACTACAAGTTCCGCTGTGCTG	0.622000													23	45					0	0	1	0	0
FOXR1	283150	broad.mit.edu	37	11	118849510	118849510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118849510G>A	ENST00000317011.3	+	2	305	c.80G>A	c.(79-81)cGa>cAa	p.R27Q		NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1	27					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.R27Q(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TATAAACTCCGAATTGTTAAG	0.448000													46	132					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43813610	43813610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43813610G>A	ENST00000382031.1	+	5	684	c.653G>A	c.(652-654)gGa>gAa	p.G218E	MAP1A_ENST00000399453.1_5'UTR|MAP1A_ENST00000300231.5_5'UTR			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	0						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGCCACCTGGGATTATCCAGT	0.547000													16	80					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	18021541	18021541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18021541C>T	ENST00000262608.8	+	14	1835	c.1835C>T	c.(1834-1836)cCa>cTa	p.P612L	CECR2_ENST00000400573.4_Missense_Mutation_p.P611L|CECR2_ENST00000400585.2_Missense_Mutation_p.P470L	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	653	Poly-Ser.				chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		CCAGCAGTACCAGGAACATTT	0.542000													24	38					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204939816	204939816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204939816G>A	ENST00000367172.4	+	11	1404	c.1076G>A	c.(1075-1077)cGa>cAa	p.R359Q	NFASC_ENST00000513543.1_Missense_Mutation_p.R370Q|NFASC_ENST00000338586.6_Missense_Mutation_p.R359Q|NFASC_ENST00000367169.4_Missense_Mutation_p.R359Q|NFASC_ENST00000360049.4_Missense_Mutation_p.R370Q|NFASC_ENST00000367171.4_Missense_Mutation_p.R359Q|NFASC_ENST00000401399.1_Missense_Mutation_p.R359Q|NFASC_ENST00000539706.1_Missense_Mutation_p.R370Q|NFASC_ENST00000403080.1_Missense_Mutation_p.R359Q|NFASC_ENST00000367170.4_Missense_Mutation_p.R359Q|NFASC_ENST00000339876.6_Missense_Mutation_p.R359Q|NFASC_ENST00000404907.1_Missense_Mutation_p.R370Q|NFASC_ENST00000404076.1_Missense_Mutation_p.R353Q|NFASC_ENST00000338515.6_Missense_Mutation_p.R359Q			O94856	NFASC_HUMAN	neurofascin	359	Ig-like C2-type 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTGGTGTGTCGAGCCAATGGA	0.542000													21	68					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26689615	26689615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26689615G>A	ENST00000436292.1	-	5	1165	c.1045C>T	c.(1045-1047)Cca>Tca	p.P349S	ZNF683_ENST00000374204.1_Missense_Mutation_p.P349S|ZNF683_ENST00000403843.1_Missense_Mutation_p.P349S|ZNF683_ENST00000349618.3_Missense_Mutation_p.P349S			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		CACTGGAATGGACGCTCTCCA	0.602000													5	15					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76381981	76381981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76381981G>A	ENST00000357063.3	+	11	2978	c.1718G>A	c.(1717-1719)cGa>cAa	p.R573Q	LMO7_ENST00000377534.3_Missense_Mutation_p.R573Q|LMO7_ENST00000321797.8_Missense_Mutation_p.R288Q|LMO7_ENST00000526202.1_Intron|LMO7_ENST00000341547.4_Intron|LMO7_ENST00000465261.2_Missense_Mutation_p.R288Q			Q8WWI1	LMO7_HUMAN	LIM domain 7	573						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		ATTGTTCGCCGAATTCCAGCA	0.453000													11	125					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120007815	120007815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:120007815C>T	ENST00000371311.3	-	2	1089	c.835G>A	c.(835-837)Gaa>Aaa	p.E279K		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	279										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TCTTTCTCTTCCTCGCCTGCA	0.458000													210	149					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216405294	216405294	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216405294C>T	ENST00000366943.2	-	14	3380		c.e14+1		USH2A_ENST00000366942.3_Splice_Site|USH2A_ENST00000307340.3_Splice_Site			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)						maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAAAGATGTACCTTCCAGTCT	0.363000										HNSCC(13;0.011)			34	179					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56140423	56140423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56140423G>A	ENST00000319441.4	+	10	1596	c.1432G>A	c.(1432-1434)Gac>Aac	p.D478N	PCK1_ENST00000543666.1_Missense_Mutation_p.D161N|PCK1_ENST00000535860.1_3'UTR	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	478					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CATCATGCATGACCCCTTTGC	0.502000													35	80					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33412138	33412138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33412138G>A	ENST00000404816.2	+	6	1770	c.1417G>A	c.(1417-1419)Gga>Aga	p.G473R	LTBP1_ENST00000404525.1_Missense_Mutation_p.G147R|LTBP1_ENST00000402934.1_Missense_Mutation_p.G147R|LTBP1_ENST00000390003.4_Missense_Mutation_p.G147R|LTBP1_ENST00000418533.2_Missense_Mutation_p.G147R|LTBP1_ENST00000407925.1_Missense_Mutation_p.G147R|LTBP1_ENST00000354476.3_Missense_Mutation_p.G473R			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	473					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAGCCAGCAAGGAGTCAAAGG	0.527000													15	55					0	0	1	0	0
PPP1R32	220004	broad.mit.edu	37	11	61257301	61257301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61257301G>A	ENST00000338608.2	+	12	1216	c.1091G>A	c.(1090-1092)cGa>cAa	p.R364Q	PPP1R32_ENST00000366212.4_5'UTR|PPP1R32_ENST00000538185.1_Missense_Mutation_p.R41Q|PPP1R32_ENST00000432063.2_Missense_Mutation_p.R344Q	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	364																	GGCTGGACTCGAGGTGGCATC	0.642000													14	34					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27228254	27228254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27228254C>T	ENST00000380036.4	+	22	3693	c.3251C>T	c.(3250-3252)tCa>tTa	p.S1084L	TEK_ENST00000519097.1_Missense_Mutation_p.S936L|TEK_ENST00000406359.4_Missense_Mutation_p.S1041L	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	1084	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GAGAGGCCATCATTTGCCCAG	0.413000													16	109					0	0	1	0	0
SEMA4B	10509	broad.mit.edu	37	15	90768248	90768248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90768248C>T	ENST00000411539.2	+	10	1503	c.1243C>T	c.(1243-1245)Ctc>Ttc	p.L415F	SEMA4B_ENST00000332496.6_Missense_Mutation_p.L415F|SEMA4B_ENST00000379122.3_Missense_Mutation_p.L410F	NM_198925.2	NP_945119.1			sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B											NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)	12	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			ATCCCTGCAGCTCCCAGACCG	0.627000													27	96					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269471	150269471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150269471C>T	ENST00000255945.2	+	3	488	c.313C>T	c.(313-315)Cgc>Tgc	p.R105C	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Missense_Mutation_p.R119C	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	105							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAGATTATTCGCTGCATTCT	0.522000													16	64					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169910	207169910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207169910G>A	ENST00000374423.3	+	5	1044	c.658G>A	c.(658-660)Gac>Aac	p.D220N		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	220							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TAGCAAATGTGACCCAAACAA	0.408000													6	37					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88767368	88767368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88767368G>A	ENST00000497649.2	+	6	1654	c.1276G>A	c.(1276-1278)Gaa>Aaa	p.E426K	MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000560249.1_Missense_Mutation_p.E337K|MEPE_ENST00000424957.3_Missense_Mutation_p.E450K|MEPE_ENST00000540395.1_Missense_Mutation_p.E337K|MEPE_ENST00000395102.4_Missense_Mutation_p.E481K|MEPE_ENST00000361056.3_Missense_Mutation_p.E450K			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	450					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AATCAAAAACGAAATGGATTC	0.378000													13	64					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45284519	45284519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45284519G>A	ENST00000270279.3	+	3	619	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K	CBLC_ENST00000341505.4_Missense_Mutation_p.E186K	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	186	Cbl-PTB.|EF-hand-like.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				CCACCCTGTGGAACCAGGCTG	0.642000			M		AML								26	67					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38748773	38748773	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38748773G>A	ENST00000449082.2	-	25	4382	c.4383C>T	c.(4381-4383)ccC>ccT	p.P1461P		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1461					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGCTCACCAGGGGCCGTGGGA	0.547000													27	72					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150489234	150489234	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150489234G>A	ENST00000447204.2	-	6	1002	c.630C>T	c.(628-630)ttC>ttT	p.F210F	TMEM176B_ENST00000492607.1_Silent_p.F210F|TMEM176B_ENST00000450753.2_Silent_p.F173F|TMEM176B_ENST00000326442.5_Silent_p.F210F|TMEM176B_ENST00000434545.1_Silent_p.F210F|TMEM176B_ENST00000429904.2_Silent_p.F210F	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	210					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGACAGCCAGGAACAGGGCAC	0.522000													15	61					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12945613	12945613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12945613G>A	ENST00000589272.1	-	2	393	c.64C>T	c.(64-66)Ctc>Ttc	p.L22F	MAST1_ENST00000591495.1_Intron|RTBDN_ENST00000393233.2_5'UTR|RTBDN_ENST00000322912.5_Missense_Mutation_p.L22F			Q9BSG5	RTBDN_HUMAN	retbindin	0						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						AAGGTGGGGAGGGATTCTGTA	0.582000													16	58					0	0	1	0	0
SLC5A4	6527	broad.mit.edu	37	22	32650159	32650159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32650159G>A	ENST00000266086.4	-	2	188	c.177C>T	c.(175-177)ttC>ttT	p.F59F	RP1-90G24.10_ENST00000434942.1_RNA	NM_014227.2	NP_055042.1	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (glucose activated ion channel), member 4	59					carbohydrate transport|sodium ion transport	integral to membrane	symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|pancreas(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GACCAGCGAGGAAGAAGCCTC	0.532000													25	47					0	0	1	0	0
DDX54	79039	broad.mit.edu	37	12	113603608	113603608	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113603608G>A	ENST00000314045.7	-	13	1671	c.1645_splice	c.e13+1	p.F548_splice	DDX54_ENST00000306014.5_Splice_Site_p.F548_splice	NM_001111322.1	NP_001104792.1	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	548					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AGGACTCACTGAAGAGGGGGT	0.642000													10	29					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234915531	234915531	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234915531G>A	ENST00000324695.4	+	23	3205	c.3165G>A	c.(3163-3165)tgG>tgA	p.W1055*	TRPM8_ENST00000433712.2_Nonsense_Mutation_p.W633*	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	1055						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTCTGGCATGGGAGGGTGTCA	0.398000													13	30					0	0	1	0	0
NPPB	4879	broad.mit.edu	37	1	11918354	11918354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11918354C>T	ENST00000376468.3	-	2	402	c.305G>A	c.(304-306)cGa>cAa	p.R102Q		NM_002521.2	NP_002512.1	P16860	ANFB_HUMAN	natriuretic peptide B	102					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	CTTGGGGCTTCGTGGTGCCCG	0.642000													15	36					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88780705	88780705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88780705G>A	ENST00000418177.2	-	2	703	c.336C>T	c.(334-336)ttC>ttT	p.F112F	GRM5_ENST00000455756.2_Silent_p.F112F|GRM5_ENST00000305447.4_Silent_p.F112F|GRM5_ENST00000393297.1_Silent_p.F112F|GRM5_ENST00000305432.5_Silent_p.F112F|GRM5_ENST00000393294.3_Silent_p.F112F			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	112					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.F112L(2)		NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AATCTCTTATGAACTCAATGC	0.527000													28	36					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21327590	21327590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21327590C>T	ENST00000256958.2	+	4	402	c.306C>T	c.(304-306)ttC>ttT	p.F102F		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	102					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TCGGTTGTTTCATTATGGGAA	0.343000													14	70					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38131207	38131207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38131207C>T	ENST00000406386.3	+	9	5119	c.4864C>T	c.(4864-4866)Cct>Tct	p.P1622S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1622					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AAACGATGTCCCTGAGCAGGA	0.677000											OREG0026548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	67					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103124664	103124664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103124664C>T	ENST00000295269.4	+	5	1782	c.1325C>T	c.(1324-1326)cCt>cTt	p.P442L		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	442					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TTTTTGCTTCCTCTGTCTCTT	0.378000													31	60					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	31952984	31952984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31952984C>T	ENST00000432498.1	+	7	994	c.601C>T	c.(601-603)Cgt>Tgt	p.R201C	SFI1_ENST00000540643.1_Missense_Mutation_p.R177C|SFI1_ENST00000400288.2_Missense_Mutation_p.R201C|SFI1_ENST00000400289.1_Missense_Mutation_p.R119C|SFI1_ENST00000414585.1_Intron|SFI1_ENST00000443326.1_Missense_Mutation_p.R119C|SFI1_ENST00000443011.1_Intron	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	201					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						CGTGGTTGTTCGTAGGACCAA	0.468000													20	57					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24681389	24681389	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:24681389G>T	ENST00000396475.2	+	4	471	c.172G>T	c.(172-174)Gaa>Taa	p.E58*	MPP6_ENST00000222644.4_Nonsense_Mutation_p.E58*|MPP6_ENST00000409761.1_5'UTR	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	58	L27 2.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						CAATAACTTGGAATTAGTCAA	0.338000													32	79					2.08457e-15	2.09563e-15	1	1	0
SPNS3	201305	broad.mit.edu	37	17	4337325	4337325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4337325C>T	ENST00000355530.2	+	1	343	c.63C>T	c.(61-63)tcC>tcT	p.S21S	SPNS3_ENST00000576069.1_3'UTR|SPNS3_ENST00000333476.2_5'UTR	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	21					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						AGGGCCAGTCCCCAGGGCCAG	0.701000													11	21					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86010709	86010709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:86010709C>T	ENST00000383699.3	+	8	1509	c.882C>T	c.(880-882)ttC>ttT	p.F294F	CADM2_ENST00000407528.2_Silent_p.F285F|CADM2_ENST00000405615.2_Silent_p.F287F	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	285	Ig-like C2-type 2.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ACATTCTTTTCCTGAACAAAA	0.433000													42	111					0	0	1	0	0
C8orf47	203111	broad.mit.edu	37	8	99101747	99101747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:99101747G>A	ENST00000318528.3	+	2	861	c.502G>A	c.(502-504)Gac>Aac	p.D168N	C8orf47_ENST00000545282.1_Intron	NM_173549.2	NP_775820.2	Q6P6B1	CH047_HUMAN	chromosome 8 open reading frame 47	168										kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(2)	13	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			AGTAGAGAAGGACTCTCTCAG	0.517000													5	47					0	0	1	0	0
C1orf158	93190	broad.mit.edu	37	1	12820790	12820790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12820790C>T	ENST00000288048.5	+	4	707	c.491C>T	c.(490-492)tCa>tTa	p.S164L	C1orf158_ENST00000376210.3_Missense_Mutation_p.S126L	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	164										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		ACTTATACTTCATCCTACCCC	0.567000													34	86					0	0	1	0	0
NPPB	4879	broad.mit.edu	37	1	11918493	11918493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11918493C>T	ENST00000376468.3	-	2	263	c.166G>A	c.(166-168)Gag>Aag	p.E56K		NM_002521.2	NP_002512.1	P16860	ANFB_HUMAN	natriuretic peptide B	56					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	ACCTGCAGCTCCGACAGTTTG	0.657000													17	31					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	3040238	3040238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3040238G>A	ENST00000398052.4	+	15	2024	c.1681G>A	c.(1681-1683)Ggg>Agg	p.G561R	GRK4_ENST00000398051.4_Intron|GRK4_ENST00000345167.6_Missense_Mutation_p.G529R|GRK4_ENST00000504933.1_Intron|GRK4_ENST00000509545.1_3'UTR	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	561						cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTTCAGAAGAGGGGTAAAAAG	0.373000													19	84					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18330167	18330167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18330167C>T	ENST00000355502.3	-	12	1714	c.843G>A	c.(841-843)gaG>gaA	p.E281E	PDE4C_ENST00000594465.2_Silent_p.E281E|PDE4C_ENST00000262805.11_Silent_p.E249E|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000539010.1_Silent_p.E50E|PDE4C_ENST00000447275.2_Silent_p.E175E|PDE4C_ENST00000594617.2_Silent_p.E281E			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	281					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GTGGGGCCTCCTCAGCGGTCA	0.652000													10	49					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6457306	6457306	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6457306G>A	ENST00000358945.3	-	13	2249	c.1809C>T	c.(1807-1809)ttC>ttT	p.F603F	SCNN1A_ENST00000540037.1_Silent_p.F281F|SCNN1A_ENST00000396966.2_3'UTR|SCNN1A_ENST00000360168.3_Silent_p.F640F|SCNN1A_ENST00000228916.2_Silent_p.F581F|SCNN1A_ENST00000543768.1_Silent_p.F604F			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	581					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	GCAGCATGAGGAACATGATGA	0.617000													23	38					0	0	1	0	0
NFS1	9054	broad.mit.edu	37	20	34257603	34257603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34257603G>A	ENST00000374092.4	-	13	1385	c.1315C>T	c.(1315-1317)Ctc>Ttc	p.L439F	NFS1_ENST00000374085.1_Missense_Mutation_p.L379F|NFS1_ENST00000541387.1_Missense_Mutation_p.L388F|NFS1_ENST00000540053.1_Missense_Mutation_p.L237F|NFS1_ENST00000498084.1_5'UTR|NFS1_ENST00000397425.1_Missense_Mutation_p.L379F	NM_021100.4	NP_066923.3	Q9Y697	NFS1_HUMAN	NFS1 cysteine desulfurase	439					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	18	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	ATCTCCCAGAGAGGGCTGCCA	0.527000													35	72					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084376	53084376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:53084376C>T	ENST00000276480.7	-	10	1728	c.1045G>A	c.(1045-1047)Gga>Aga	p.G349R		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	349						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ATTTGTCTTCCACCCATGTCG	0.378000													43	125					0	0	1	0	0
PRSS22	64063	broad.mit.edu	37	16	2903927	2903927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2903927C>T	ENST00000161006.3	-	5	721	c.656G>A	c.(655-657)gGa>gAa	p.G219E	PRSS22_ENST00000571228.1_Missense_Mutation_p.G109E	NM_022119.3	NP_071402.1	Q9GZN4	BSSP4_HUMAN	protease, serine, 22	219	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|skin(2)	10						AGTGATGGGTCCCTGTCCTGC	0.637000													20	48					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67053896	67053896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:67053896G>A	ENST00000295568.4	+	3	558	c.427G>A	c.(427-429)Gat>Aat	p.D143N	KBTBD8_ENST00000469661.1_Intron|KBTBD8_ENST00000417314.2_Missense_Mutation_p.D169N|KBTBD8_ENST00000460576.1_Intron	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	169										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		GGAACTCGGAGATCGATCAAA	0.383000													20	79					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133795854	133795854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:133795854G>A	ENST00000321016.8	-	14	2044	c.1814C>T	c.(1813-1815)cCt>cTt	p.P605L	IGSF9B_ENST00000533871.2_Missense_Mutation_p.P605L			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	605						integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		AGTTGTAATAGGGAATGCTGC	0.647000													3	5					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54605263	54605263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54605263C>T	ENST00000371330.1	-	4	2127	c.1280G>A	c.(1279-1281)gGa>gAa	p.G427E	CDCP2_ENST00000530059.1_Intron	NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	427						extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						TCTTAGGGGTCCCGAGAGTGG	0.582000													16	31					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	336757	336757	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:336757G>C	ENST00000343164.4	-	8	961	c.909C>G	c.(907-909)taC>taG	p.Y303*	SLC6A13_ENST00000445055.2_Nonsense_Mutation_p.Y211*	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	303					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GGTACTTGTTGTAGCTGCCCA	0.562000													17	39					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129147903	129147903	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:129147903C>T	ENST00000540052.1	+	3	1199	c.1155C>T	c.(1153-1155)acC>acT	p.T385T	BCORL1_ENST00000218147.7_Silent_p.T385T|BCORL1_ENST00000359304.2_Silent_p.T385T|BCORL1_ENST00000303743.5_Silent_p.T385T	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	385	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						ctgcacccaccccagccccca	0.642000													5	0					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37707082	37707082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37707082C>T	ENST00000248901.6	+	10	1049	c.862C>T	c.(862-864)Ctc>Ttc	p.L288F		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	288	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CGACAACTGCCTCTACTACTT	0.627000													48	128					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16282772	16282772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16282772C>T	ENST00000205557.7	-	13	1724	c.1695G>A	c.(1693-1695)gaG>gaA	p.E565E	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	565	ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CAAAGGCTTTCTCTGCATTCA	0.582000													17	46					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94495007	94495007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94495007G>A	ENST00000370225.3	-	30	4619	c.4533C>T	c.(4531-4533)ccC>ccT	p.P1511P		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1511					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GTACCTGGGGGGGCGGGAGGC	0.627000													6	5					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886742	23886742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23886742G>A	ENST00000355349.3	-	31	4485	c.4323C>T	c.(4321-4323)gcC>gcT	p.A1441A		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1441					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCTTGTCCAGGGCTGCAGCAG	0.612000													42	121					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79029900	79029900	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79029900C>T	ENST00000446378.2	+	2	5343	c.5312C>T	c.(5311-5313)cCa>cTa	p.P1771L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1771						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAAATAGGCCCATTACCACCA	0.408000													31	70					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104703895	104703895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:104703895C>T	ENST00000334877.4	+	5	818	c.284C>T	c.(283-285)cCt>cTt	p.P95L	KMT2E_ENST00000311117.3_Missense_Mutation_p.P95L|KMT2E_ENST00000476671.1_Missense_Mutation_p.P95L|KMT2E_ENST00000257745.4_Missense_Mutation_p.P95L|KMT2E_ENST00000334914.7_5'UTR					lysine (K)-specific methyltransferase 2E																		TTTACCACTCCTAATTTTGAT	0.438000													37	101					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272640	52272640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52272640C>T	ENST00000598776.1	+	2	1501	c.729C>T	c.(727-729)ctC>ctT	p.L243L	FPR2_ENST00000340023.6_Silent_p.L243L|FPR2_ENST00000598953.1_Silent_p.L243L	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	243					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						TACGGGTCCTCACTGCTGTGG	0.498000													26	48					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211158482	211158482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211158482C>T	ENST00000352451.3	-	5	668	c.521G>A	c.(520-522)gGt>gAt	p.G174D	MYL1_ENST00000341685.4_Missense_Mutation_p.G130D|MYL1_ENST00000496436.1_5'UTR	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	174	EF-hand 3.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GTCTTCTTGACCTGCCATCAG	0.428000													51	216					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47786986	47786986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47786986C>T	ENST00000359568.5	+	15	3204	c.3097C>T	c.(3097-3099)Cac>Tac	p.H1033Y	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1033					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					TGTGCGGGACCACCTGCGAAC	0.587000													28	81					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96788538	96788538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96788538G>A	ENST00000359933.4	-	18	3683	c.2790C>T	c.(2788-2790)atC>atT	p.I930I		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	930										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GAGAATTGCTGATTGCTTTAT	0.333000													30	50					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35823538	35823538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35823538G>A	ENST00000085219.5	+	3	189	c.123G>A	c.(121-123)tgG>tgA	p.W41*	CD22_ENST00000536635.2_Nonsense_Mutation_p.W41*|CD22_ENST00000595419.1_3'UTR|CD22_ENST00000270311.6_5'UTR|CD22_ENST00000544992.2_Nonsense_Mutation_p.W41*|CD22_ENST00000594250.1_Nonsense_Mutation_p.W41*|CD22_ENST00000419549.2_5'UTR|CD22_ENST00000341773.6_Nonsense_Mutation_p.W41*	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	41	Ig-like V-type.				cell adhesion		protein binding|sugar binding	p.W41*(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CCTGCGTCTGGATCCCCTGCA	0.502000													30	81					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218700808	218700808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:218700808G>A	ENST00000171887.4	-	18	3211	c.2759C>T	c.(2758-2760)tCc>tTc	p.S920F	TNS1_ENST00000430930.1_Missense_Mutation_p.S920F|TNS1_ENST00000419504.1_Missense_Mutation_p.S920F	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	920						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CTGGACAGGGGAGCGAACCCC	0.622000													37	66					0	0	1	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862608	25862608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25862608C>T	ENST00000397060.4	-	3	265	c.156G>A	c.(154-156)acG>acA	p.T52T	SLC17A3_ENST00000361703.6_Silent_p.T52T|SLC17A3_ENST00000360657.3_Silent_p.T52T	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	52					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						TTTGTGCTATCGTTGTGAAAT	0.413000													28	119					0	0	1	0	0
OR1I1	126370	broad.mit.edu	37	19	15198561	15198561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15198561C>T	ENST00000209540.2	+	1	771	c.685C>T	c.(685-687)Cct>Tct	p.P229S		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						CTTTAAGATCCCTTCTACTCG	0.517000													22	61					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115335717	115335717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115335717C>T	ENST00000537906.1	+	5	413	c.251C>T	c.(250-252)tCa>tTa	p.S84L	HABP2_ENST00000351270.3_Silent_p.F95F|HABP2_ENST00000542051.1_Silent_p.F69F|HABP2_ENST00000541666.1_Silent_p.F95F			Q14520	HABP2_HUMAN	hyaluronan binding protein 2	0	EGF-like 1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		GGAGCACCTTCACATGCAGCT	0.527000													39	145					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155774872	155774872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155774872G>A	ENST00000437809.1	-	11	1635	c.1513C>T	c.(1513-1515)Ccc>Tcc	p.P505S	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Missense_Mutation_p.P505S|GON4L_ENST00000368331.1_Missense_Mutation_p.P505S|GON4L_ENST00000271883.5_Missense_Mutation_p.P505S			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	505					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGGCCCAGGGGAACATCTTTC	0.498000													41	101					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595335	179595335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179595335G>A	ENST00000589042.1	-	61	18149	c.17925C>T	c.(17923-17925)ttC>ttT	p.F5975F	TTN_ENST00000342992.6_Silent_p.F4731F|TTN_ENST00000591111.1_Silent_p.F5658F|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5658	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATTTCCAAGAAGGCAGTAT	0.453000													24	114					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38840443	38840443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38840443G>A	ENST00000359357.3	+	48	6725	c.6471G>A	c.(6469-6471)atG>atA	p.M2157I	DNAH8_ENST00000441566.1_Missense_Mutation_p.M2121I|DNAH8_ENST00000449981.2_Missense_Mutation_p.M2374I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AAATGCGAATGAATCCAAAAG	0.453000													27	73					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42747230	42747230	+	Silent	SNP	C	C	T	rs138017620		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42747230C>T	ENST00000372980.3	-	3	2075	c.1203G>A	c.(1201-1203)gcG>gcA	p.A401A		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	401	Ala-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGGCCTGTTCCGCTGCCTCAG	0.617000													33	149					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52131192	52131192	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52131192T>A	ENST00000222107.4	-	5	1030	c.892A>T	c.(892-894)Atc>Ttc	p.I298F	SIGLEC5_ENST00000599649.1_Missense_Mutation_p.I298F|SIGLEC5_ENST00000429354.3_Missense_Mutation_p.I298F|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.I298F|SIGLEC5_ENST00000534261.2_Missense_Mutation_p.I298F			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	298	Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		AGCTCCAAGATCCCGGTATTG	0.597000													37	103					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54903692	54903692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54903692G>A	ENST00000293373.6	+	7	737	c.658G>A	c.(658-660)Gag>Aag	p.E220K	NCKAP1L_ENST00000552211.1_3'UTR|NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E170K	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	220					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CCAGGGGGCTGAGCAGTGGCG	0.507000													69	131					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32891138	32891138	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32891138C>T	ENST00000330048.5	-	0	2925					NR_003083.2																						ATGGAGAGATCAATGACAAAG	0.597000													25	104					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358358	10358358	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10358358C>T	ENST00000255381.2	-	21	2445	c.2335G>A	c.(2335-2337)Gaa>Aaa	p.E779K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	779	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TCTCGCATTTCCTCTAGAGTT	0.418000													28	41					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150731895	150731895	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150731895C>T	ENST00000358849.4	+	5	837	c.744C>T	c.(742-744)tcC>tcT	p.S248S	ABCB8_ENST00000356058.4_Silent_p.S285S|ABCB8_ENST00000297504.6_Silent_p.S265S|ABCB8_ENST00000477719.1_Silent_p.S248S|ABCB8_ENST00000477092.1_Silent_p.S248S|ABCB8_ENST00000542328.1_Silent_p.S160S|ABCB8_ENST00000498578.1_Silent_p.S248S	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	265	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.S248S(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTAAGTCATCCTTCAAGCTTG	0.572000													10	44					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072128	9072128	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9072128G>A	ENST00000397910.4	-	3	15521	c.15318C>T	c.(15316-15318)gcC>gcT	p.A5106A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5108	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTTTAGAAGTGGCCAGTATCT	0.428000													45	96					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31652321	31652321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31652321C>T	ENST00000375494.3	+	7	711	c.711C>T	c.(709-711)ctC>ctT	p.L237L		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	237	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										CATTGCCTCTCATCTCCAACC	0.587000													11	44					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173883494	173883494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:173883494G>A	ENST00000264111.6	+	22	2303	c.2116G>A	c.(2116-2118)Gag>Aag	p.E706K	RAPGEF4_ENST00000538974.1_Missense_Mutation_p.E536K|RAPGEF4_ENST00000535187.1_Missense_Mutation_p.E487K|RAPGEF4_ENST00000539331.1_Missense_Mutation_p.E554K|RAPGEF4_ENST00000540783.1_Missense_Mutation_p.E554K|RAPGEF4_ENST00000397081.3_Missense_Mutation_p.E707K|RAPGEF4_ENST00000409036.1_Missense_Mutation_p.E707K|RAPGEF4_ENST00000397087.3_Missense_Mutation_p.E563K			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	707					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GGGCTCCGGGGAGGGCCTGAT	0.502000													19	100					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139905714	139905714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139905714G>A	ENST00000265662.5	-	38	5994	c.5847C>T	c.(5845-5847)ttC>ttT	p.F1949F	ABCA2_ENST00000371605.3_Silent_p.F1948F|ABCA2_ENST00000341511.6_Silent_p.F1949F			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1948					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGTAGTTGGGGAAAATGAGGA	0.617000													5	36					0	0	1	0	0
BFAR	51283	broad.mit.edu	37	16	14738443	14738443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:14738443C>T	ENST00000426842.2	+	1	299	c.61C>T	c.(61-63)Ccc>Tcc	p.P21S	BFAR_ENST00000563971.1_Silent_p.F80F|BFAR_ENST00000261658.2_Silent_p.F80F			Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	0					anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						GGGAAGGTTTCCCCAAAGTCA	0.408000													39	108					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25965266	25965266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:25965266G>A	ENST00000435504.4	-	13	4233	c.3940C>T	c.(3940-3942)Ccg>Tcg	p.P1314S	ASXL2_ENST00000336112.4_Missense_Mutation_p.P1286S|ASXL2_ENST00000404843.1_Missense_Mutation_p.P797S|ASXL2_ENST00000272341.4_Missense_Mutation_p.P797S			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	1314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACAACTTCGGGGTTTGCAGG	0.557000													5	10					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087437	92087437	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92087437G>A	ENST00000298047.6	+	1	2176	c.2159G>A	c.(2158-2160)aGa>aAa	p.R720K	FAT3_ENST00000525166.1_Missense_Mutation_p.R570K|FAT3_ENST00000409404.2_Missense_Mutation_p.R720K|FAT3_ENST00000541502.1_Missense_Mutation_p.R720K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	720					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.R720I(2)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCAATTAATAGACAGGGACCA	0.403000										TCGA Ovarian(4;0.039)			63	183					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241528843	241528843	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241528843C>T	ENST00000391984.2	+	2	421	c.225C>T	c.(223-225)ttC>ttT	p.F75F	CAPN10_ENST00000404753.3_Silent_p.F75F|CAPN10_ENST00000270364.7_Silent_p.F75F|CAPN10_ENST00000354082.4_Silent_p.F75F|CAPN10_ENST00000391982.2_Silent_p.F75F|CAPN10_ENST00000352879.4_Intron	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	75	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		ATTGCTGGTTCCTGTGTGCCT	0.602000													51	120					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97082687	97082687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:97082687G>A	ENST00000335456.7	-	6	1146	c.1126C>T	c.(1126-1128)Ccc>Tcc	p.P376S	NUTM2F_ENST00000253262.4_Missense_Mutation_p.P391S|NUTM2F_ENST00000341207.4_Missense_Mutation_p.P376S					NUT family member 2F																		ACTTCAGGGGGGATCTCCTCA	0.662000													46	70					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152647133	152647133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152647133G>A	ENST00000367255.5	-	80	15999	c.15398C>T	c.(15397-15399)tCg>tTg	p.S5133L	SYNE1_ENST00000448038.1_Missense_Mutation_p.S5062L|SYNE1_ENST00000423061.1_Missense_Mutation_p.S5062L|SYNE1_ENST00000265368.4_Missense_Mutation_p.S5133L|SYNE1_ENST00000341594.5_Intron	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5133					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGACTAGACGAAGTCTTCAA	0.348000										HNSCC(10;0.0054)			22	28					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947903	237947903	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237947903C>T	ENST00000366574.2	+	90	13208	c.12891C>T	c.(12889-12891)ttC>ttT	p.F4297F	RYR2_ENST00000542537.1_Silent_p.F4281F|RYR2_ENST00000360064.6_Silent_p.F4303F	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4297					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTTGCACTTCGTGGCCAGCG	0.463000													16	39					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107601054	107601054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107601054G>A	ENST00000393561.1	-	16	2406	c.2222C>T	c.(2221-2223)aCc>aTc	p.T741I	LAMB1_ENST00000222399.6_Missense_Mutation_p.T717I|LAMB1_ENST00000393560.1_Missense_Mutation_p.T717I			P07942	LAMB1_HUMAN	laminin, beta 1	717	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCTCCCACGGTGAAGATGTC	0.493000													17	59					0	0	1	0	0
CCDC138	165055	broad.mit.edu	37	2	109489954	109489954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:109489954C>T	ENST00000295124.4	+	14	1801	c.1741C>T	c.(1741-1743)Cgt>Tgt	p.R581C	CCDC138_ENST00000412964.2_Intron	NM_144978.1	NP_659415.1	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	581										endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	14						TTTATTTTTTCGTACTTGCTC	0.368000													42	87					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81929530	81929530	+	Silent	SNP	G	G	A	rs149315555	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81929530G>A	ENST00000359376.3	+	13	1405	c.1191G>A	c.(1189-1191)tcG>tcA	p.S397S		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	397	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						TTGTTACCTCGAGGTCAGTTG	0.542000													56	67					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38765020	38765020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38765020C>T	ENST00000449082.2	-	18	3252	c.3253G>A	c.(3253-3255)Gag>Aag	p.E1085K		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1085					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTGCTGCCCTCAGAGGAGCTT	0.597000													4	13					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130841476	130841476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130841476C>T	ENST00000245255.3	+	13	1690	c.1418C>T	c.(1417-1419)cCa>cTa	p.P473L		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	473					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GATTACAATCCACAATTTGCA	0.368000													35	33					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98514412	98514412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:98514412C>T	ENST00000268042.6	+	8	1416	c.1252C>T	c.(1252-1254)Ctc>Ttc	p.L418F	ARRDC4_ENST00000538249.1_Missense_Mutation_p.L331F	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	418					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TTCCTTCATTCTCTGAACGTA	0.398000													12	177					0	0	1	0	0
ANKRD7	56311	broad.mit.edu	37	7	117874902	117874902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117874902G>A	ENST00000357099.4	+	4	675	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K	ANKRD7_ENST00000433239.1_Missense_Mutation_p.E95K|ANKRD7_ENST00000417525.1_Missense_Mutation_p.E95K|ANKRD7_ENST00000265224.4_Missense_Mutation_p.E148K|ANKRD7_ENST00000477532.1_3'UTR			Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	148					male gonad development					breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)	29						GCTTGAATACGAAGCTGATCT	0.333000													10	45					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77415255	77415255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77415255G>A	ENST00000451710.3	-	17	2390	c.2153C>T	c.(2152-2154)cCc>cTc	p.P718L	TRPM6_ENST00000376864.4_Missense_Mutation_p.P718L|TRPM6_ENST00000361255.3_Missense_Mutation_p.P713L|TRPM6_ENST00000360774.1_Missense_Mutation_p.P718L|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Missense_Mutation_p.P713L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	718					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TGAAACAAAGGGTCGTAATCC	0.463000													16	56					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108380691	108380691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108380691C>T	ENST00000265843.4	-	6	5653	c.5543G>A	c.(5542-5544)aGa>aAa	p.R1848K	EXPH5_ENST00000428840.1_Missense_Mutation_p.R1772K|EXPH5_ENST00000443411.1_Missense_Mutation_p.R1660K|EXPH5_ENST00000525344.1_Missense_Mutation_p.R1841K	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1848					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AGATCTGAATCTTCGACTGTA	0.458000													22	41					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43441229	43441229	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43441229G>A	ENST00000446844.3	-	0	89				PSG7_ENST00000471557.1_RNA|PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GGGGCCCCATGGTCTCTGCTC	0.577000													20	139					0	0	1	0	0
INO80E	283899	broad.mit.edu	37	16	30016748	30016748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30016748C>T	ENST00000563197.1	+	7	1737	c.720C>T	c.(718-720)atC>atT	p.I240I	INO80E_ENST00000567705.1_Silent_p.I223I|INO80E_ENST00000304516.7_Silent_p.I201I	NM_173618.1	NP_775889.1	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	240					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	6						ACCTGGTGATCGACATCCCGG	0.662000											OREG0023725	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	11					0	0	1	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77310494	77310494	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77310494G>A	ENST00000558012.1	+	2	531	c.42G>A	c.(40-42)agG>agA	p.R14R	PSTPIP1_ENST00000379595.3_Silent_p.R14R|PSTPIP1_ENST00000559295.1_Silent_p.R14R|PSTPIP1_ENST00000267939.5_Silent_p.R13R	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	14	FCH.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						CACAGTGCAGGGACTTCACAG	0.607000													3	6					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15132462	15132462	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15132462G>A	ENST00000292574.3	+	5	1158	c.1076G>A	c.(1075-1077)gGa>gAa	p.G359E		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	359					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						CTGATGAGGGGAACTATCCTC	0.582000													7	65					0	0	1	0	0
MYL2	4633	broad.mit.edu	37	12	111353546	111353546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111353546C>T	ENST00000228841.8	-	3	189	c.142G>A	c.(142-144)Gat>Aat	p.D48N	MYL2_ENST00000548438.1_Intron	NM_000432.3	NP_000423.2	P10916	MLRV_HUMAN	myosin, light chain 2, regulatory, cardiac, slow	48	EF-hand 1.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle	p.D48Y(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	12						TCTCTCAGATCGTTCTTGTCA	0.527000													59	128					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43413171	43413171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43413171G>A	ENST00000310826.5	-	3	1217	c.1034C>T	c.(1033-1035)tCg>tTg	p.S345L	ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398511.3_Missense_Mutation_p.S345L|ZBTB21_ENST00000398499.1_Missense_Mutation_p.S345L|ZBTB21_ENST00000398505.3_Missense_Mutation_p.S345L	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		GCTATCCATCGACAATGACCG	0.478000													25	52					0	0	1	0	0
EIF3F	8665	broad.mit.edu	37	11	8014500	8014500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8014500C>T	ENST00000533626.1	+	6	1208	c.582C>T	c.(580-582)gcC>gcT	p.A194A	EIF3F_ENST00000309828.4_Silent_p.A194A|EIF3F_ENST00000449102.2_Silent_p.A45A|EIF3F_ENST00000537635.1_Silent_p.A209A			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	194	MPN.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCCGAGAGGCCCCCAACCCCA	0.562000													26	109					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121694075	121694075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121694075C>T	ENST00000393386.2	+	26	6775	c.6364C>T	c.(6364-6366)Cct>Tct	p.P2122S	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.P1255S	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2122	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GGTTATGATTCCTGATGGCCA	0.428000													54	123					0	0	1	0	0
PRR5	55615	broad.mit.edu	37	22	45128160	45128160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45128160C>T	ENST00000403581.1	+	8	1122	c.513C>T	c.(511-513)gcC>gcT	p.A171A	PRR5-ARHGAP8_ENST00000361473.5_Intron|ARHGAP8_ENST00000517296.3_Silent_p.A148A|PRR5_ENST00000336985.6_Silent_p.A148A|PRR5_ENST00000477331.1_3'UTR|PRR5-ARHGAP8_ENST00000352766.7_Silent_p.A148A|ARHGAP8_ENST00000389773.5_Intron	NM_001198721.1	NP_001185650.1			proline rich 5 (renal)											central_nervous_system(1)|endometrium(2)|lung(6)|prostate(1)|skin(1)	11		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		GCCAGCTGGCCCTGCTGCACT	0.672000													13	43					0	0	1	0	0
DTL	51514	broad.mit.edu	37	1	212276201	212276201	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:212276201C>T	ENST00000366991.4	+	15	2426	c.2112C>T	c.(2110-2112)agC>agT	p.S704S	DTL_ENST00000542077.1_Silent_p.S662S|DTL_ENST00000475419.1_3'UTR	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	704					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		TCACGCCCAGCTCCATGAGGA	0.388000													20	43					0	0	1	0	0
ARMC1	55156	broad.mit.edu	37	8	66517673	66517673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:66517673G>A	ENST00000276569.3	-	5	810	c.566C>T	c.(565-567)tCa>tTa	p.S189L	ARMC1_ENST00000458464.2_Missense_Mutation_p.S87L	NM_018120.4	NP_060590.1	Q9NVT9	ARMC1_HUMAN	armadillo repeat containing 1	189					metal ion transport		metal ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(8)|skin(1)	14			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			TTTCAAATCTGAACGGATTCG	0.333000													20	78					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72050250	72050250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72050250G>A	ENST00000355327.3	+	15	2559	c.2425G>A	c.(2425-2427)Gag>Aag	p.E809K	THSD4_ENST00000261862.6_Missense_Mutation_p.E809K|THSD4_ENST00000357769.4_Missense_Mutation_p.E449K|THSD4_ENST00000567838.1_3'UTR			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	809	TSP type-1 4.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GTGCTCAGCGGAGTGTGGGGC	0.612000													20	74					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	20998468	20998468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20998468G>A	ENST00000247986.2	-	12	2995	c.2685C>T	c.(2683-2685)atC>atT	p.I895I	KIF17_ENST00000400463.3_Silent_p.I895I|KIF17_ENST00000490034.1_5'UTR|KIF17_ENST00000375044.1_Silent_p.I795I			Q9P2E2	KIF17_HUMAN	kinesin family member 17	895					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CGGGATGTGGGATCTTCCAGA	0.572000													14	103					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59182605	59182605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:59182605G>A	ENST00000380516.2	-	15	2041	c.1954C>T	c.(1954-1956)Cgt>Tgt	p.R652C	AC025918.2_ENST00000452467.1_RNA|SLTM_ENST00000536328.1_Missense_Mutation_p.R221C	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	652	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCCCGTTCACGAATTATTCTA	0.433000													52	105					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174260	51174260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51174260C>T	ENST00000440970.1	-	2	2013	c.1582G>A	c.(1582-1584)Gaa>Aaa	p.E528K	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.E625K	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	625					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCACTCTCTTCGCTTTTGCCA	0.642000													11	49					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12711222	12711222	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12711222G>A	ENST00000376221.1	+	2	249	c.249G>A	c.(247-249)aaG>aaA	p.K83K		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	83						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GAATTAAAAAGGACCCTGAAC	0.483000													45	114					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234549	21234549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21234549C>T	ENST00000233242.1	-	26	5318	c.5191G>A	c.(5191-5193)Gtc>Atc	p.V1731I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1731					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCTTGACTGACCTTGAAGTTG	0.448000													75	274					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121694076	121694076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121694076C>T	ENST00000393386.2	+	26	6776	c.6365C>T	c.(6364-6366)cCt>cTt	p.P2122L	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.P1255L	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2122	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GTTATGATTCCTGATGGCCAA	0.428000													54	123					0	0	1	0	0
IFNA21	3452	broad.mit.edu	37	9	21166096	21166096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21166096C>T	ENST00000380225.1	-	1	563	c.516G>A	c.(514-516)atG>atA	p.M172I		NM_002175.2	NP_002166.2	P01568	IFN21_HUMAN	interferon, alpha 21	172					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)	14				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGAAGGATCTCATGATTTCTG	0.383000													33	314					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159783292	159783292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159783292C>T	ENST00000321935.6	+	8	1130	c.1044C>T	c.(1042-1044)tcC>tcT	p.S348S	FCRL6_ENST00000392235.3_Silent_p.S246S|FCRL6_ENST00000339348.5_Silent_p.S341S|FCRL6_ENST00000368106.3_Silent_p.S341S			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	341						integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					CCCTTCCATCCCAGATACCAC	0.557000													22	86					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106552875	106552875	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:106552875C>T	ENST00000369096.4	+	5	1074	c.840C>T	c.(838-840)ctC>ctT	p.L280L	PRDM1_ENST00000369091.2_Silent_p.L244L|PRDM1_ENST00000369089.3_Silent_p.L146L	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	280					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		AAAAGGACCTCGATGACTTTA	0.507000			"""D, N, Mis, F, S"""		DLBCL								44	199					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573155	38573155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38573155C>T	ENST00000222345.6	+	3	1459	c.950C>T	c.(949-951)tCc>tTc	p.S317F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	317					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCTGGGCGTTCCCCGGGGGAG	0.687000													4	20					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72324234	72324234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72324234G>A	ENST00000263563.6	+	19	2645	c.2377G>A	c.(2377-2379)Gcc>Acc	p.A793T		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CCTGGAGAAGGCCGACTCCTG	0.642000													49	134					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44468071	44468071	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44468071G>A	ENST00000372310.3	-	8	1041	c.876C>T	c.(874-876)gcC>gcT	p.A292A	SLC6A9_ENST00000372306.3_Silent_p.A292A|SLC6A9_ENST00000537678.1_Silent_p.A227A|SLC6A9_ENST00000475075.2_Silent_p.A181A|SLC6A9_ENST00000360584.2_Silent_p.A365A|SLC6A9_ENST00000372307.3_Silent_p.A227A|SLC6A9_ENST00000357730.2_Silent_p.A311A	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	365						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	AGATCTGGGAGGCAGCATCAC	0.627000													14	98					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176708836	176708836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176708836G>A	ENST00000367662.3	+	13	5037	c.3873G>A	c.(3871-3873)gaG>gaA	p.E1291E		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1291					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTCCCGGAGAGCATCAGCAGC	0.458000													36	64					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12856145	12856145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12856145G>A	ENST00000332296.7	+	4	1528	c.1425G>A	c.(1423-1425)taG>taA	p.*475*	PRAMEF1_ENST00000400814.3_Silent_p.*230*	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	0										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTTGCTGCTAGGGAAGGCGTG	0.517000													17	137					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256006	15256006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15256006C>T	ENST00000378116.4	-	8	1587	c.1581G>A	c.(1579-1581)gaG>gaA	p.E527E		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	527						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GCTGTTCTTTCTCAGGTGATG	0.537000													28	225					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400661	85400661	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85400661C>T	ENST00000258888.5	+	6	3465	c.3298C>T	c.(3298-3300)Ctg>Ttg	p.L1100L		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1100					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCCACCTTCCTGCCCTCTGA	0.627000													22	77					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24832642	24832642	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24832642G>A	ENST00000376451.2	+	14	3752	c.3492G>A	c.(3490-3492)gaG>gaA	p.E1164E	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000376454.3_Silent_p.E1481E|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000396446.1_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1481					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						aaaagatagaggaggaggaag	0.448000													6	51					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2752230	2752230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2752230G>A	ENST00000312371.4	+	7	1583	c.1215G>A	c.(1213-1215)aaG>aaA	p.K405K	AMZ1_ENST00000489665.1_Intron|AMZ1_ENST00000407112.1_3'UTR	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	405							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		AGGCCATCAAGGAGCATGAAC	0.687000													6	13					0	0	1	0	0
STRIP1	85369	broad.mit.edu	37	1	110596312	110596312	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110596312C>T	ENST00000369795.3	+	21	2314	c.2292C>T	c.(2290-2292)ttC>ttT	p.F764F	STRIP1_ENST00000369796.1_Silent_p.F669F	NM_033088.2	NP_149079.2			striatin interacting protein 1																		CTTGGGACTTCCAGGCAGAGG	0.582000											OREG0013647	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	68					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27157863	27157863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27157863C>T	ENST00000380036.4	+	2	529	c.87C>T	c.(85-87)atC>atT	p.I29I	TEK_ENST00000519097.1_Intron|TEK_ENST00000406359.4_Silent_p.I29I	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	29					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TGATCTTGATCAATTCCCTAC	0.463000													83	163					0	0	1	0	0
SNORD114-3	767579	broad.mit.edu	37	14	101419695	101419695	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101419695G>A	ENST00000364969.1	+	0	10					NR_003195.1																						ATGGACCAATGATGACCACTG	0.478000													16	108					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149490673	149490673	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149490673G>A	ENST00000378016.2	+	0	6047							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTGGTGGAGGGGACGGGAGAA	0.642000													16	29					0	0	1	0	0
SP6	80320	broad.mit.edu	37	17	45925633	45925633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45925633G>A	ENST00000536300.1	-	2	494	c.163C>T	c.(163-165)Ctc>Ttc	p.L55F	SP6_ENST00000342234.2_Missense_Mutation_p.L55F	NM_001258248.1	NP_001245177.1	Q3SY56	SP6_HUMAN	Sp6 transcription factor	55					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(5)|prostate(1)|skin(1)	8						CCCAGCGGGAGGCTCTGCAGC	0.692000													10	16					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45679538	45679538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45679538C>T	ENST00000270172.3	-	4	691	c.208G>A	c.(208-210)Gga>Aga	p.G70R	DNMT3L_ENST00000418993.1_Missense_Mutation_p.G70R	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	70	ADD.				DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		CAGATCCCTCCCTCAAACAGA	0.552000													7	25					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34090712	34090712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34090712G>A	ENST00000373381.4	-	34	5615	c.5439C>T	c.(5437-5439)atC>atT	p.I1813I	CSMD2_ENST00000373380.1_Silent_p.I686I|CSMD2_ENST00000373377.1_5'UTR|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1773	CUB 11.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGAGGCACTCGATCTCTGGCG	0.657000													27	66					0	0	1	0	0
LRRC58	116064	broad.mit.edu	37	3	120053973	120053973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120053973G>A	ENST00000295628.3	-	3	738	c.643C>T	c.(643-645)Cgt>Tgt	p.R215C		NM_001099678.1	NP_001093148.1	Q96CX6	LRC58_HUMAN	leucine rich repeat containing 58	215										large_intestine(2)|lung(5)	7				GBM - Glioblastoma multiforme(114;0.147)		CTTAGGGAACGAAGTGAATGT	0.343000													15	51					0	0	1	0	0
C16orf46	123775	broad.mit.edu	37	16	81095509	81095509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81095509C>T	ENST00000378611.4	-	3	560	c.445G>A	c.(445-447)Gac>Aac	p.D149N	C16orf46_ENST00000444657.3_5'UTR|C16orf46_ENST00000299578.5_Missense_Mutation_p.D149N|RP11-303E16.8_ENST00000564536.1_RNA	NM_001100873.1	NP_001094343.1	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46	149										NS(1)|endometrium(2)|large_intestine(3)|lung(9)|prostate(1)|stomach(1)|urinary_tract(1)	18						AAGCAGATGTCGCTAATTGCC	0.557000													55	229					0	0	1	0	0
TMEM9	252839	broad.mit.edu	37	1	201115881	201115881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201115881G>A	ENST00000367330.1	-	3	770	c.254C>T	c.(253-255)aCc>aTc	p.T85I	TMEM9_ENST00000367333.1_Missense_Mutation_p.T88I|TMEM9_ENST00000367334.5_Missense_Mutation_p.T85I|TMEM9_ENST00000367329.1_Missense_Mutation_p.T85I|TMEM9_ENST00000367332.1_Missense_Mutation_p.T88I			Q9P0T7	TMEM9_HUMAN	transmembrane protein 9	85					transport	integral to membrane|late endosome membrane|lysosomal membrane				liver(1)|lung(1)|stomach(1)	3		Breast(1374;0.000301)				GATGGTGGTGGTGCTGCGCTC	0.592000													18	97					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823763	38823763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38823763G>A	ENST00000303592.3	-	2	633	c.375C>T	c.(373-375)ttC>ttT	p.F125F		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	125					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					CCGAGAACAGGAAGGCACCCA	0.697000													30	99					0	0	1	0	0
C4orf26	152816	broad.mit.edu	37	4	76489459	76489459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76489459C>T	ENST00000311623.4	+	2	238	c.203C>T	c.(202-204)cCc>cTc	p.P68L	C4orf26_ENST00000435974.2_Missense_Mutation_p.P83S	NM_001257072.1|NM_178497.3	NP_001244001.1|NP_848592.2	Q17RF5	CD026_HUMAN	chromosome 4 open reading frame 26	68						extracellular region				kidney(1)|large_intestine(4)|stomach(1)	6			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ACAAAGACACCCAGGTGTCCC	0.522000													31	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073656	9073656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9073656G>A	ENST00000397910.4	-	3	13993	c.13790C>T	c.(13789-13791)tCc>tTc	p.S4597F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4599	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTCAGGGAGGATGTTGGCTC	0.512000													19	36					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222037	140222037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140222037C>T	ENST00000531613.1	+	1	1131	c.1131C>T	c.(1129-1131)ctC>ctT	p.L377L	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Silent_p.L377L|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACCTCGATTCAGGTG	0.517000													53	112					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4861673	4861673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4861673G>A	ENST00000321919.9	-	14	1489	c.1413C>T	c.(1411-1413)atC>atT	p.I471I	GLYR1_ENST00000591451.1_Silent_p.I465I|GLYR1_ENST00000436648.5_Silent_p.I390I|GLYR1_ENST00000381983.3_Silent_p.I454I	NM_032569.3	NP_115958.2	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	471					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						CCTGATTGAGGATGTCCAAGA	0.542000													8	35					0	0	1	0	0
MED9	55090	broad.mit.edu	37	17	17394729	17394729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:17394729C>T	ENST00000268711.3	+	2	417	c.361C>T	c.(361-363)Ctc>Ttc	p.L121F		NM_018019.2	NP_060489.1	Q9NWA0	MED9_HUMAN	mediator complex subunit 9	121					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GCTGCAGAGCCTCCGGGAGCA	0.557000													30	53					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458484	248458484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248458484G>A	ENST00000317996.1	-	1	396	c.397C>T	c.(397-399)Ctc>Ttc	p.L133F		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CAGCTCATGAGAGTGGGATAT	0.602000													15	49					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171494075	171494075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171494075C>T	ENST00000367742.3	+	10	1413	c.1171C>T	c.(1171-1173)Ccc>Tcc	p.P391S	PRRC2C_ENST00000426496.2_Missense_Mutation_p.P389S|PRRC2C_ENST00000338920.4_Missense_Mutation_p.P389S|PRRC2C_ENST00000392078.3_Missense_Mutation_p.P391S|PRRC2C_ENST00000476522.1_3'UTR			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	389							protein C-terminus binding										AGCAAAAGTTCCCTATGGGAA	0.373000													8	30					0	0	1	0	0
MS4A2	2206	broad.mit.edu	37	11	59857212	59857212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59857212C>T	ENST00000278888.3	+	2	206	c.104C>T	c.(103-105)tCa>tTa	p.S35L		NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2	35					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	GAAGTATCTTCAGGCAGACTA	0.468000													36	77					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31572557	31572557	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31572557G>A	ENST00000379416.3	-	26	3012	c.2964C>T	c.(2962-2964)ttC>ttT	p.F988F		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	988					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTTACTTGTTGAACTTGTCAA	0.458000													57	121					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121358776	121358776	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121358776G>A	ENST00000260197.7	+	4	693	c.564G>A	c.(562-564)tgG>tgA	p.W188*	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	188					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGTACCTCTGGATCACGTTTG	0.517000													133	335					0	0	1	0	0
RAB25	57111	broad.mit.edu	37	1	156038175	156038175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156038175C>T	ENST00000361084.5	+	3	595	c.354C>T	c.(352-354)atC>atT	p.I118I	RAB25_ENST00000487325.1_3'UTR	NM_020387.2	NP_065120.2	P57735	RAB25_HUMAN	RAB25, member RAS oncogene family	118					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	Hepatocellular(266;0.158)|all_neural(408;0.195)					AAGCCACGATCGTCGTCATGC	0.592000													22	91					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21563423	21563423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:21563423G>A	ENST00000382592.4	-	4	901	c.496C>T	c.(496-498)Cca>Tca	p.P166S	LATS2_ENST00000542899.1_Missense_Mutation_p.P166S|LATS2_ENST00000472754.1_5'UTR	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	166					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CGCGTCACTGGGGTTGGCATG	0.607000													22	47					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48506595	48506595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48506595G>A	ENST00000435803.1	+	44	12882	c.12858G>A	c.(12856-12858)cgG>cgA	p.R4286R	ABCA13_ENST00000544596.1_Intron	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4286					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGCTTCTGCGGAAGTTTAGAG	0.478000													28	90					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53945699	53945699	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53945699C>T	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		TACTGATAATCTCAAGGAGGC	0.423000													15	53					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70260694	70260694	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70260694C>T	ENST00000301843.8	+	6	544	c.338C>T	c.(337-339)tCg>tTg	p.S113L	CTTN_ENST00000376561.3_Missense_Mutation_p.S113L|CTTN_ENST00000346329.3_Missense_Mutation_p.S113L	NM_005231.3	NP_005222.2	Q14247	SRC8_HUMAN	cortactin	113						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		AAGCACTGCTCGCAGGTGGAC	0.552000													28	97					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57761237	57761237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57761237G>A	ENST00000360716.3	+	16	2333	c.2112G>A	c.(2110-2112)gaG>gaA	p.E704E	CCDC135_ENST00000394337.4_Silent_p.E704E|CCDC135_ENST00000336825.8_Silent_p.E639E			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	704						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						AGCTTCGAGAGGAAGAGGAGG	0.547000													8	140					0	0	1	0	0
NR4A3	8013	broad.mit.edu	37	9	102607113	102607113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:102607113C>T	ENST00000330847.1	+	5	1514	c.1470C>T	c.(1468-1470)gtC>gtT	p.V490V	NR4A3_ENST00000395097.2_Silent_p.V479V			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	479	Ligand-binding (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				AGCTGTTTGTCCTCAGACTTT	0.393000			T	EWSR1	extraskeletal myxoid chondrosarcoma								16	36					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87757920	87757920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87757920C>T	ENST00000398204.4	+	9	1005	c.682C>T	c.(682-684)Cgt>Tgt	p.R228C	ADAM22_ENST00000398201.4_Missense_Mutation_p.R228C|ADAM22_ENST00000398209.3_Missense_Mutation_p.R228C|ADAM22_ENST00000315984.7_Missense_Mutation_p.R228C|ADAM22_ENST00000439864.1_Missense_Mutation_p.R228C|ADAM22_ENST00000265727.7_Missense_Mutation_p.R228C	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	228					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GTTACAGCTTCGTCGATATCC	0.368000													38	80					0	0	1	0	0
TCL1A	8115	broad.mit.edu	37	14	96178115	96178115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96178115G>A	ENST00000402399.1	-	3	451	c.322C>T	c.(322-324)Ctc>Ttc	p.L108F	TCL1A_ENST00000555202.1_Missense_Mutation_p.L108F|TCL1A_ENST00000554012.1_Missense_Mutation_p.L108F|TCL1A_ENST00000556450.1_Missense_Mutation_p.L108F|RP11-164H13.1_ENST00000553445.1_RNA|RP11-164H13.1_ENST00000547644.2_RNA	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	108					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		AGCAGCTCGAGAAGCATGTCC	0.562000			T	TRA@	T-CLL								8	19					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209452	140209452	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140209452G>A	ENST00000529310.1	+	1	1890	c.1776G>A	c.(1774-1776)gcG>gcA	p.A592A	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGTGGTGGCGAAGGTGCGCG	0.687000													27	97					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6422908	6422908	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6422908G>A	ENST00000449001.2	+	2	650	c.156G>A	c.(154-156)ggG>ggA	p.G52G	PLEKHG6_ENST00000396988.3_Silent_p.G84G|PLEKHG6_ENST00000011684.7_Silent_p.G84G|PLEKHG6_ENST00000536531.1_Silent_p.G84G	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	84					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						AGAGGCACGGGGGCCATGTGG	0.642000													7	61					0	0	1	0	0
ABCA11P	79963	broad.mit.edu	37	4	420330	420330	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:420330G>A	ENST00000451020.2	-	0	708					NR_002451.2																						CAGTACCCAAGAACTTGAGGC	0.488000													31	77					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60366656	60366656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60366656G>A	ENST00000371204.3	-	8	1354	c.1311C>T	c.(1309-1311)gcC>gcT	p.A437A	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	437					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					AAGGCATAAAGGCTTCCCTTT	0.522000													10	84					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23893247	23893247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23893247C>T	ENST00000355349.3	-	23	2953	c.2791G>A	c.(2791-2793)Gag>Aag	p.E931K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	931			E -> K (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCATTCATCTCCTCCTCATCC	0.527000													37	137					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22890774	22890774	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22890774C>T	ENST00000543184.1	-	5	2107	c.1245G>A	c.(1243-1245)ggG>ggA	p.G415G	PRAME_ENST00000398743.2_Silent_p.G415G|PRAME_ENST00000402697.1_Silent_p.G415G|PRAME_ENST00000398741.1_Silent_p.G415G|PRAME_ENST00000405655.3_Silent_p.G415G|PRAME_ENST00000539862.1_Silent_p.G399G|PRAME_ENST00000424204.2_Silent_p.G399G	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	415					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		AGATGGAATTCCCGTAGAAGC	0.547000													16	50					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116692388	116692388	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:116692388C>T	ENST00000357780.3	-	3	500	c.386G>A	c.(385-387)cGa>cAa	p.R129Q		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		ctgaagctctcgcaggttgtc	0.662000													3	12					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284432	159284432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159284432G>A	ENST00000332217.5	-	1	17	c.18C>T	c.(16-18)tcC>tcT	p.S6S		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					TCACAAAAGTGGAATTTAGCT	0.438000													65	162					0	0	1	0	0
ACO1	48	broad.mit.edu	37	9	32405519	32405519	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32405519C>T	ENST00000379923.1	+	3	221	c.15C>T	c.(13-15)ttC>ttT	p.F5F	ACO1_ENST00000541043.1_5'UTR|ACO1_ENST00000309951.5_Silent_p.F5F	NM_001278352.1	NP_001265281.1	P21399	ACOC_HUMAN	aconitase 1, soluble	5					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding	p.F5F(1)		breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		GCAACCCATTCGCACACCTTG	0.398000													13	55					0	0	1	0	0
NPM2	10361	broad.mit.edu	37	8	21891760	21891760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:21891760C>T	ENST00000397940.1	+	6	1520	c.505C>T	c.(505-507)Ccc>Tcc	p.P169S	NPM2_ENST00000289820.6_Missense_Mutation_p.P169S|NPM2_ENST00000518119.1_Missense_Mutation_p.P169S|NPM2_ENST00000521157.1_Missense_Mutation_p.P169S|NPM2_ENST00000381530.5_Intron			Q86SE8	NPM2_HUMAN	nucleophosmin/nucleoplasmin 2	169					chromatin remodeling|embryo development|oocyte differentiation|positive regulation of meiosis|regulation of exit from mitosis|single fertilization	cytoplasmic chromatin|nuclear chromatin	histone binding|nucleic acid binding			large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		AAGGCTGGTGCCCCAGAAGCA	0.562000													22	42					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833793	61833793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61833793G>A	ENST00000280772.1	-	37	7037	c.6846C>T	c.(6844-6846)tcC>tcT	p.S2282S	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2282					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GATCCCGCCCGGACTGAAAGG	0.498000													14	189					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121414256	121414256	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121414256G>A	ENST00000260197.7	+	13	1814		c.e13-1		SORL1_ENST00000532451.1_Splice_Site	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing						cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CATTTGGGCAGATACAGTACC	0.473000													32	93					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45459065	45459065	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45459065C>T	ENST00000548424.1	+	0	448																											TCGTTTCCTTCCTTGAGAATC	0.468000													14	27					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26204076	26204076	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26204076G>A	ENST00000264712.3	-	1	1290	c.711C>T	c.(709-711)atC>atT	p.I237I	KIF3C_ENST00000405914.1_Silent_p.I237I	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	237	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCCCACTCGGATGTGGTCCT	0.627000													27	47					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31322871	31322871	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31322871G>A	ENST00000269197.5	+	12	3059	c.3059G>A	c.(3058-3060)gGg>gAg	p.G1020E		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1020					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TCCAAAATTGGGCCACCTTTT	0.453000													7	36					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45388060	45388060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45388060G>A	ENST00000389039.6	-	30	4431	c.4046C>T	c.(4045-4047)tCc>tTc	p.S1349F	DUOX2_ENST00000603300.1_Missense_Mutation_p.S1349F			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1349	FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GCCCTTTGGGGATGAGTAGAT	0.632000													7	47					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131792787	131792787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131792787G>A	ENST00000286355.5	-	18	5697	c.3605C>T	c.(3604-3606)tCc>tTc	p.S1202F	ADCY8_ENST00000377928.3_Missense_Mutation_p.S1071F	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1202					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CCTATTGAGGGACTGGACAAG	0.537000										HNSCC(32;0.087)			43	60					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29231382	29231382	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29231382G>A	ENST00000441381.1	+	0	79																											ACAGGACAGGGGGAAAGTATC	0.478000													52	118					0	0	1	0	0
TMEM198	130612	broad.mit.edu	37	2	220413939	220413939	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220413939G>A	ENST00000344458.2	+	5	1393	c.808G>A	c.(808-810)Gag>Aag	p.E270K	TMEM198_ENST00000373883.3_Missense_Mutation_p.E270K			Q66K66	TM198_HUMAN	transmembrane protein 198	270	Arg-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGATCGCAAGGAGAAAAGGCG	0.637000													14	177					0	0	1	0	0
GPATCH2	55105	broad.mit.edu	37	1	217783509	217783509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:217783509G>A	ENST00000366934.3	-	6	1234	c.1124C>T	c.(1123-1125)cCc>cTc	p.P375L	GPATCH2_ENST00000366935.3_Intron			Q9NW75	GPTC2_HUMAN	G patch domain containing 2	0						intracellular	nucleic acid binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)	35				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		GGTTTATAGGGGAATCTCACT	0.373000													4	5					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051295	17051295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:17051295C>T	ENST00000418129.2	+	2	544	c.79C>T	c.(79-81)Cgc>Tgc	p.R27C	PLCL2_ENST00000396755.2_Missense_Mutation_p.R27C|PLCL2_ENST00000460467.1_3'UTR|PLCL2_ENST00000432376.1_Missense_Mutation_p.R27C	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	153	Gly-rich.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						CAAAAAGGTTCGCTCCAACTC	0.418000													21	66					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999996	46999996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46999996G>A	ENST00000374314.4	+	1	2071	c.1116G>A	c.(1114-1116)ctG>ctA	p.L372L	GPRIN2_ENST00000374317.1_Silent_p.L372L			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	372										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GGTCCAGCCTGGAGGAGGTGC	0.672000													16	111					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132952778	132952778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:132952778C>T	ENST00000254624.5	+	2	268	c.43C>T	c.(43-45)Cgc>Tgc	p.R15C	EFR3A_ENST00000334503.4_Missense_Mutation_p.R15C|EFR3A_ENST00000519656.1_5'UTR	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	15						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTTGCGTCCTCGCTACAAACG	0.408000													13	13					0	0	1	0	0
WIPF3	644150	broad.mit.edu	37	7	29924036	29924036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:29924036C>T	ENST00000409290.1	+	4	926	c.926C>T	c.(925-927)cCc>cTc	p.P309L	WIPF3_ENST00000409123.1_Missense_Mutation_p.P309L|WIPF3_ENST00000242140.5_Missense_Mutation_p.P309L	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	309								p.P309H(1)		breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						GCTTCTTTGCCCGCGCCCCCT	0.682000													5	7					0	0	1	0	0
C5orf48	389320	broad.mit.edu	37	5	125971753	125971753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:125971753C>T	ENST00000357147.3	+	3	238	c.225C>T	c.(223-225)ggC>ggT	p.G75G		NM_207408.1	NP_997291.1	Q6ZNM6	CE048_HUMAN	chromosome 5 open reading frame 48	75										large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	7						TCCATACTGGCCCTTTAGAAG	0.383000													30	178					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39496022	39496022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39496022C>T	ENST00000265707.5	+	10	911	c.866C>T	c.(865-867)cCt>cTt	p.P289L	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.P265L	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	289	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding	p.P289L(1)|p.P289F(1)		NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			GCAACATTTCCTGGCACTGTA	0.279000													12	59					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	39910311	39910311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39910311G>A	ENST00000350221.3	-	11	1533	c.1324C>T	c.(1324-1326)Ccc>Tcc	p.P442S		NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	442										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		GAAAGCTGGGGGAACACAGGT	0.378000													45	95					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466958	56466958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56466958G>A	ENST00000291971.3	+	3	1605	c.1534G>A	c.(1534-1536)Gaa>Aaa	p.E512K	NLRP8_ENST00000590542.1_Missense_Mutation_p.E512K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	512	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GACTTTTCAGGAATTTTTTGC	0.468000													64	209					0	0	1	0	0
NUTM2D	728130	broad.mit.edu	37	10	89127097	89127097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:89127097C>T	ENST00000412718.1	+	7	2188	c.1642C>T	c.(1642-1644)Cct>Tct	p.P548S						NUT family member 2D																		GTAGGGAGCCCCTTCAGATGC	0.632000													11	26					0	0	1	0	0
DUT	1854	broad.mit.edu	37	15	48624484	48624484	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48624484C>T	ENST00000331200.3	+	2	393	c.300C>T	c.(298-300)ccC>ccT	p.P100P	DUT_ENST00000559935.1_Silent_p.P15P|DUT_ENST00000558813.1_5'UTR|DUT_ENST00000455976.2_Silent_p.P12P|DUT_ENST00000559540.1_Silent_p.P12P|DUT_ENST00000559416.1_Silent_p.P15P	NM_001025248.1|NM_001025249.1	NP_001020419.1|NP_001020420.1	P33316	DUT_HUMAN	deoxyuridine triphosphatase	100			P -> S (in dbSNP:rs28381104).		DNA replication|dUTP metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process	mitochondrion|nucleoplasm	dUTP diphosphatase activity|protein binding			kidney(2)	2		all_lung(180;0.00265)		all cancers(107;2.66e-09)|GBM - Glioblastoma multiforme(94;6.76e-07)		CCATTTCACCCAGTAAGCGGG	0.721000								Modulation of nucleotide pools					10	42					0	0	1	0	0
FIGF	2277	broad.mit.edu	37	X	15376196	15376196	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:15376196G>A	ENST00000297904.3	-	3	850	c.421C>T	c.(421-423)Cga>Tga	p.R141*		NM_004469.4	NP_004460.1	O43915	VEGFD_HUMAN	c-fos induced growth factor (vascular endothelial growth factor D)	141					angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17	Hepatocellular(33;0.183)					CCACCACATCGGAACACGTTC	0.517000													76	70					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53058065	53058065	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53058065C>T	ENST00000359798.4	+	5	2076	c.1896C>T	c.(1894-1896)ttC>ttT	p.F632F		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		ACACAGCTTTCACGTGGAATT	0.408000													15	72					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104641424	104641424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104641424G>A	ENST00000315264.7	+	11	2260	c.1882G>A	c.(1882-1884)Gac>Aac	p.D628N	KIF26A_ENST00000423312.2_Missense_Mutation_p.D767N			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	767	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCTGGACCCCGACCGCACGCC	0.726000													4	15					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155200508	155200508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155200508C>T	ENST00000460012.1	-	23	3574	c.3217G>A	c.(3217-3219)Ggt>Agt	p.G1073S	PLCH1_ENST00000414191.1_Missense_Mutation_p.G1073S|PLCH1_ENST00000340059.7_Missense_Mutation_p.G1111S|PLCH1_ENST00000334686.6_Missense_Mutation_p.G1073S|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000494598.1_Intron			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1111					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCAGGATTACCCTTTTCCTTG	0.473000													43	91					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55032589	55032589	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55032589G>A	ENST00000417545.2	+	2	344	c.258G>A	c.(256-258)ttG>ttA	p.L86L		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	70						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ACATTCGATTGAAGAAGATGG	0.438000													29	26					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23191528	23191528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23191528G>A	ENST00000400191.3	+	5	1144	c.1126G>A	c.(1126-1128)Ggg>Agg	p.G376R	EPHB2_ENST00000374632.3_Missense_Mutation_p.G376R|EPHB2_ENST00000544305.1_Missense_Mutation_p.G376R|EPHB2_ENST00000374630.3_Missense_Mutation_p.G376R|EPHB2_ENST00000374627.1_Missense_Mutation_p.G370R|EPHB2_ENST00000465676.1_3'UTR	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	376	Fibronectin type-III 1.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CACCCGCTGCGGGGACAATGT	0.637000													39	85					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13695737	13695737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:13695737G>A	ENST00000202816.1	-	14	2447	c.2340C>T	c.(2338-2340)ttC>ttT	p.F780F		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	780	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTGTTTTCTTGAAATTGGGAT	0.388000													42	106					0	0	1	0	0
KDM3A	55818	broad.mit.edu	37	2	86678279	86678279	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:86678279C>T	ENST00000409556.1	+	5	761	c.396C>T	c.(394-396)cgC>cgT	p.R132R	KDM3A_ENST00000409064.1_Silent_p.R132R|KDM3A_ENST00000312912.5_Silent_p.R132R|KDM3A_ENST00000542128.1_Silent_p.R80R			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	132					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						CTTCTGTTCGCTTTCTGGGAG	0.358000													30	72					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158618317	158618317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158618317G>A	ENST00000368148.3	-	26	3876	c.3696C>T	c.(3694-3696)ctC>ctT	p.L1232L	SPTA1_ENST00000368147.3_Silent_p.L1232L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1232					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCAGGGGTACGAGGTCCCTTT	0.498000													56	51					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10466660	10466660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10466660C>T	ENST00000382483.3	-	4	5171	c.4948G>A	c.(4948-4950)Gag>Aag	p.E1650K		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1650					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCCTCCGCCTCCTCGCCCAGC	0.677000													15	49					0	0	1	0	0
IFNL1	282618	broad.mit.edu	37	19	39787205	39787205	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39787205G>A	ENST00000333625.2	+	1	241	c.144G>A	c.(142-144)gcG>gcA	p.A48A		NM_172140.1	NP_742152.1			interferon, lambda 1																		AGGAGCTAGCGAGCTTCAAGA	0.582000													11	27					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107417675	107417675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107417675C>T	ENST00000394872.2	-	31	3367	c.3136G>A	c.(3136-3138)Gaa>Aaa	p.E1046K	COL4A6_ENST00000372216.4_Missense_Mutation_p.E1046K|COL4A6_ENST00000545689.1_Missense_Mutation_p.E1045K|COL4A6_ENST00000334504.7_Missense_Mutation_p.E1045K|COL4A6_ENST00000538570.1_Missense_Mutation_p.E1045K			Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1046	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						CTTACACTTTCTCCTGGCATT	0.552000									Alport syndrome with Diffuse Leiomyomatosis				18	16					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095033	69095033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69095033C>T	ENST00000332644.5	-	8	1049	c.888G>A	c.(886-888)atG>atA	p.M296I		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	296	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						CTGAGAGCTTCATTTTGGCTT	0.378000													37	80					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7528297	7528297	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7528297G>A	ENST00000313599.3	-	10	2742	c.2686_splice	c.e10+1	p.S895_splice	CD163L1_ENST00000544331.1_5'UTR|CD163L1_ENST00000396630.1_Splice_Site_p.S895_splice|CD163L1_ENST00000416109.2_Splice_Site_p.S905_splice			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	895	SRCR 8.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						AAATCTCACGGGAACAGACAA	0.463000													22	67					0	0	1	0	0
PRKAB2	5565	broad.mit.edu	37	1	146638497	146638497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:146638497G>A	ENST00000254101.3	-	4	483	c.345C>T	c.(343-345)atC>atT	p.I115I	PRKAB2_ENST00000425272.2_Silent_p.I33I	NM_005399.3	NP_005390.1	O43741	AAKB2_HUMAN	protein kinase, AMP-activated, beta 2 non-catalytic subunit	115					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				NS(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	GGAGGTCCAGGATGGCAACAA	0.438000													9	43					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29275106	29275106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29275106C>T	ENST00000377160.2	+	1	704	c.640C>T	c.(640-642)Ctc>Ttc	p.L214F		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						CTCCATTGTGCTCTCCTACAT	0.468000													64	136					0	0	1	0	0
MAOA	4128	broad.mit.edu	37	X	43571145	43571145	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:43571145C>T	ENST00000338702.3	+	4	456	c.333C>T	c.(331-333)gcC>gcT	p.A111A	MAOA_ENST00000497485.1_3'UTR|MAOA_ENST00000542639.1_5'UTR	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	111					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	TTCGGGGCGCCTTTCCACCAG	0.363000													38	43					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1367606	1367606	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:1367606T>G	ENST00000446702.2	+	9	1681	c.1054T>G	c.(1054-1056)Tta>Gta	p.L352V	CNTN6_ENST00000539053.1_Missense_Mutation_p.L280V|CNTN6_ENST00000350110.2_Missense_Mutation_p.L352V			Q9UQ52	CNTN6_HUMAN	contactin 6	352	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GTATACATGGTTAAAAAATGG	0.363000													34	58					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322672	55322672	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55322672T>C	ENST00000314644.2	+	1	890	c.890T>C	c.(889-891)aTt>aCt	p.I297T		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GGATCTCACATTGCTGTTGTG	0.433000										HNSCC(20;0.049)			46	151					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69798419	69798419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69798419C>T	ENST00000251566.4	-	3	953	c.923G>A	c.(922-924)gGg>gAg	p.G308E	UGT2A3_ENST00000420231.2_Missense_Mutation_p.G19E	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	308						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AAACAGTGACCCCAGAGAAAA	0.388000													52	200					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278576	36278576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36278576C>T	ENST00000007510.4	+	21	3253	c.3109C>T	c.(3109-3111)Ccc>Tcc	p.P1037S	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.P873S|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.P876S			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1037					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CTCCCCAGCCCCCAGGGAGTG	0.697000													49	89					0	0	1	0	0
TMPPE	643853	broad.mit.edu	37	3	33134649	33134649	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33134649G>A	ENST00000342462.4	-	2	1229	c.1039C>T	c.(1039-1041)Cat>Tat	p.H347Y	GLB1_ENST00000399402.3_Intron|GLB1_ENST00000445488.2_Intron|GLB1_ENST00000307363.5_Intron|GLB1_ENST00000307377.8_Intron|TMPPE_ENST00000416695.2_Missense_Mutation_p.H210Y	NM_001039770.2	NP_001034859.2	Q6ZT21	TMPPE_HUMAN	transmembrane protein with metallophosphoesterase domain	347				H -> R (in Ref. 1; BAC87349).		integral to membrane	metal ion binding			breast(1)|large_intestine(5)|lung(6)|prostate(1)	13						TCCATGCCATGGCCAGAGTAG	0.592000													39	131					0	0	1	0	0
PTF1A	256297	broad.mit.edu	37	10	23482809	23482809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:23482809G>A	ENST00000376504.3	+	2	1165	c.961G>A	c.(961-963)Gaa>Aaa	p.E321K		NM_178161.2	NP_835455.1	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	321					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						CATAGAAAACGAACCACCATT	0.398000													38	132					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082626	9082626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9082626C>T	ENST00000397910.4	-	1	9392	c.9189G>A	c.(9187-9189)agG>agA	p.R3063R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3064	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTTGGGCTGCCTTGCCATGG	0.483000													44	129					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163279938	163279938	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163279938G>A	ENST00000332142.5	-	9	2161	c.2062C>T	c.(2062-2064)Cgc>Tgc	p.R688C	KCNH7_ENST00000328032.4_Missense_Mutation_p.R681C	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	688					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGGTGAAAGCGAATGAACTCT	0.438000													26	189					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31709925	31709925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31709925G>A	ENST00000261592.5	-	2	621	c.324C>T	c.(322-324)ttC>ttT	p.F108F	NOL4_ENST00000535475.1_5'UTR|NOL4_ENST00000269185.4_5'UTR|NOL4_ENST00000538587.1_Silent_p.F34F|NOL4_ENST00000589544.1_Silent_p.F108F	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	108						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TAATGTCAAAGAAATCTTCAA	0.393000													30	81					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41743987	41743987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41743987C>T	ENST00000301178.4	+	7	1112	c.922C>T	c.(922-924)Cgc>Tgc	p.R308C	AXL_ENST00000359092.3_Missense_Mutation_p.R308C|AXL_ENST00000593513.1_Missense_Mutation_p.R40C	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	308	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						TTATCACATCCGCGTGGCATG	0.647000													51	151					0	0	1	0	0
LYNX1	66004	broad.mit.edu	37	8	143846155	143846155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143846155G>A	ENST00000335822.5	-	5	891	c.264C>T	c.(262-264)gtC>gtT	p.V88V	LYNX1_ENST00000523332.1_Intron|LYNX1_ENST00000317543.7_Silent_p.V54V|RP11-706C16.7_ENST00000523657.1_RNA	NM_023946.2	NP_076435.1	Q86SR0	SLUR2_HUMAN	Ly6/neurotoxin 1	54	UPAR/Ly6.					extracellular region				endometrium(1)|lung(2)|skin(1)	4	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGTTGCTGAGGACCCCTGAGT	0.622000													20	43					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17104380	17104380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17104380G>A	ENST00000443236.1	-	12	1284	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	CPAMD8_ENST00000388925.4_Missense_Mutation_p.P371L	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	371						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GCTGCCATCGGGGTAGGATAG	0.532000													15	55					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73662134	73662134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73662134C>T	ENST00000339764.1	+	1	771	c.20C>T	c.(19-21)tCt>tTt	p.S7F		NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	7	J.				apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					GATTATTACTCTGTGCTCGGG	0.587000													15	26					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409675	59409675	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:59409675G>A	ENST00000301645.3	-	3	533	c.396C>T	c.(394-396)acC>acT	p.T132T		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	132					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GGCCCTGCAGGGTTTTGATGA	0.458000									Neonatal Giant Cell Hepatitis				36	89					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821097	43821097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43821097C>T	ENST00000417669.1	+	2	550	c.106C>T	c.(106-108)Cgg>Tgg	p.R36W	MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000443721.1_Missense_Mutation_p.R36W|MPPED1_ENST00000542779.1_Missense_Mutation_p.R36W|MPPED1_ENST00000538182.1_Missense_Mutation_p.R69W			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	36							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				GATGGCCGCTCGGCGGCACCA	0.662000													23	36					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46656397	46656397	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46656397C>T	ENST00000544460.1	+	1	786	c.532C>T	c.(532-534)Cgc>Tgc	p.R178C	TDRD6_ENST00000316081.6_Missense_Mutation_p.R178C	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	178					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding	p.R178C(1)		NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GCTGCTCCATCGCCTGGTCCT	0.682000													22	75					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68950480	68950480	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68950480G>T	ENST00000288368.4	+	7	1069	c.792G>T	c.(790-792)gtG>gtT	p.V264V	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	264	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AAGAACGGGTGTTTTTTCTTT	0.403000													26	54					2.41591e-17	2.42948e-17	1	1	0
ZBTB7C	201501	broad.mit.edu	37	18	45566511	45566511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:45566511C>T	ENST00000588982.1	-	3	1469	c.968G>A	c.(967-969)gGa>gAa	p.G323E	ZBTB7C_ENST00000586438.1_Missense_Mutation_p.G323E|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.G323E|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.G323E|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.G323E			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	323	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CTTGATGGGTCCCAGAGGCCC	0.632000													29	71					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149260061	149260061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:149260061C>T	ENST00000407073.1	+	13	5317	c.4320C>T	c.(4318-4320)gtC>gtT	p.V1440V	MBD5_ENST00000404807.1_Silent_p.V1673V	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1440	PWWP.					chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ACAGCCGTGTCCGGAAAAGGA	0.408000													9	41					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40433119	40433119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40433119C>T	ENST00000221347.6	-	2	1157	c.1150G>A	c.(1150-1152)Gag>Aag	p.E384K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	384	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCACAGCCTCCCAGGTGAGC	0.617000													25	47					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161139349	161139349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161139349C>T	ENST00000308192.9	+	8	874	c.811C>T	c.(811-813)Ccc>Tcc	p.P271S		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	271					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATCTTCTGGTCCCACCTACCA	0.512000													43	55					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508751	37508751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37508751G>A	ENST00000374660.1	+	40	4399	c.4300G>A	c.(4300-4302)Gag>Aag	p.E1434K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1315K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1315K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1371						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AGAGAAAAATGAGGAGATATT	0.269000													7	22					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123759877	123759877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123759877G>A	ENST00000223642.1	-	21	2767	c.2738C>T	c.(2737-2739)tCa>tTa	p.S913L		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	913					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	AGTCTCCAGTGAAAAATTGAT	0.393000													14	71					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78210729	78210729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78210729C>T	ENST00000361193.3	+	8	1019	c.739C>T	c.(739-741)Cgc>Tgc	p.R247C	SLC26A11_ENST00000572725.1_Missense_Mutation_p.R247C|SLC26A11_ENST00000546047.2_Missense_Mutation_p.R247C|SLC26A11_ENST00000411502.3_Missense_Mutation_p.R247C	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	247						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TCTCCTAGCTCGCAACGCCCT	0.632000													71	166					0	0	1	0	0
COA6	388753	broad.mit.edu	37	1	234509379	234509379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:234509379C>T	ENST00000366615.4	+	1	178	c.167C>T	c.(166-168)tCc>tTc	p.S56F		NM_001206641.1	NP_001193570.1			cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)																		GTGACAGTTTCCTCCCGTCGA	0.687000													17	153					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902233	51902233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:51902233G>A	ENST00000268919.4	+	1	1995	c.1839G>A	c.(1837-1839)ggG>ggA	p.G613G		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	613					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CAATTTCAGGGAAGGGATCTA	0.423000													25	95					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113538213	113538213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113538213C>T	ENST00000416899.2	+	9	1456	c.1330C>T	c.(1330-1332)Ccc>Tcc	p.P444S	MUSK_ENST00000374448.4_Missense_Mutation_p.P444S|MUSK_ENST00000189978.5_Missense_Mutation_p.P444S|MUSK_ENST00000374438.1_Missense_Mutation_p.P35L			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	444	FZ.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						GCATTGGGACCCCACGGCCTG	0.488000													14	210					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81657081	81657081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81657081G>A	ENST00000550584.2	-	30	3939	c.3644C>T	c.(3643-3645)tCc>tTc	p.S1215F	PPFIA2_ENST00000549396.1_Missense_Mutation_p.S1215F|PPFIA2_ENST00000541570.2_Missense_Mutation_p.S751F|PPFIA2_ENST00000548586.1_Missense_Mutation_p.S1209F|PPFIA2_ENST00000552948.1_Missense_Mutation_p.S1194F|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Missense_Mutation_p.S1200F|PPFIA2_ENST00000550359.2_Missense_Mutation_p.S1062F|PPFIA2_ENST00000407050.4_Missense_Mutation_p.S1114F|PPFIA2_ENST00000333447.7_Missense_Mutation_p.S1203F|PPFIA2_ENST00000443686.3_Missense_Mutation_p.S1110F|PPFIA2_ENST00000541017.1_Missense_Mutation_p.S401F	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	1114										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TGTTTCTGAGGACCCAGGCAT	0.458000													12	21					0	0	1	0	0
ACOX1	51	broad.mit.edu	37	17	73949573	73949573	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73949573G>A	ENST00000537812.1	-	7	1437	c.789C>T	c.(787-789)atC>atT	p.I263I	ACOX1_ENST00000301608.4_Silent_p.I301I|ACOX1_ENST00000293217.5_Silent_p.I301I	NM_001185039.1	NP_001171968.1	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	301					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						CGCTGTATCGGATGGCAATGG	0.532000													22	65					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76073015	76073015	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:76073015G>A	ENST00000395215.3	+	0	404																											AAGCACAGATGGAGCAGTTAG	0.473000													16	123					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50249977	50249977	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50249977C>T	ENST00000246801.3	-	6	824	c.742G>A	c.(742-744)Gag>Aag	p.E248K	TSKS_ENST00000358830.3_Missense_Mutation_p.E48K	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	248							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		tcctgcttctcctccggctcc	0.697000													7	15					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111409812	111409812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111409812G>A	ENST00000265162.5	+	2	1102	c.760G>A	c.(760-762)Gga>Aga	p.G254R		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	254					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CAAAGAATACGGAGCACTTTC	0.383000													28	70					0	0	1	0	0
ZNF490	57474	broad.mit.edu	37	19	12692196	12692196	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12692196G>A	ENST00000311437.6	-	5	815	c.693C>T	c.(691-693)ttC>ttT	p.F231F		NM_020714.2	NP_065765.1	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	18						AGAGAAATGCGAAGGCTTTGC	0.423000													42	83					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95549901	95549901	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95549901C>T	ENST00000371418.4	+	5	737	c.477C>T	c.(475-477)ttC>ttT	p.F159F	LGI1_ENST00000371413.3_Silent_p.F159F|LGI1_ENST00000542308.1_Silent_p.F111F	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	159					axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				AAGATATTTTCAAAGGCCTGG	0.333000													24	64					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12954498	12954498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12954498G>A	ENST00000235347.4	-	3	864	c.785C>T	c.(784-786)cCa>cTa	p.P262L		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	262										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGAGGAATGGAGAGTCCAA	0.473000													23	286					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12313762	12313762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12313762C>T	ENST00000256186.2	+	2	338	c.47C>T	c.(46-48)tCg>tTg	p.S16L		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	16	Ser-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cttccttcatcgtcttcccat	0.493000													15	44					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370099	240370099	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240370099G>A	ENST00000319653.9	+	5	2217	c.1986_splice	c.e5-1	p.E663_splice		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	663					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.E806K(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CGCCCTTCAGGAAGTTGTTGA	0.393000													9	38					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479935	4479935	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4479935C>T	ENST00000237837.1	-	3	475	c.330G>A	c.(328-330)ccG>ccA	p.P110P		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	110					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity	p.P110P(1)		NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			TGCAGTTCTCCGGGTCGAAAT	0.607000													15	85					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458788	248458788	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248458788G>A	ENST00000317996.1	-	1	92	c.93C>T	c.(91-93)gcC>gcT	p.A31A		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TCAAAACGGTGGCCAGAAGCA	0.493000													19	176					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169141143	169141143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169141143G>A	ENST00000256935.8	+	18	1851	c.1771G>A	c.(1771-1773)Ggg>Agg	p.G591R	DOCK2_ENST00000540750.1_5'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.G83R	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	591	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGTGTTGGGGGGCTTTCTGT	0.547000													22	49					0	0	1	0	0
ATP8B5P	158381	broad.mit.edu	37	9	35449850	35449850	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35449850G>A	ENST00000430846.1	+	0	2700																											ATGCTATAAAGAACATCTTCA	0.423000													10	34					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600303	92600303	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92600303G>T	ENST00000298047.6	+	21	12072	c.12055G>T	c.(12055-12057)Gtg>Ttg	p.V4019L	FAT3_ENST00000525166.1_Missense_Mutation_p.V3869L|FAT3_ENST00000533797.1_Missense_Mutation_p.V354L|FAT3_ENST00000409404.2_Missense_Mutation_p.V4019L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4019					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTGGGCTGCGTGCTCTATCC	0.657000										TCGA Ovarian(4;0.039)			3	3					0.115264	0.115272	1	1	0
PCDH9	5101	broad.mit.edu	37	13	67205501	67205501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:67205501C>T	ENST00000544246.1	-	4	3872	c.3181G>A	c.(3181-3183)Gaa>Aaa	p.E1061K	PCDH9_ENST00000328454.5_Missense_Mutation_p.E1027K|PCDH9_ENST00000377865.2_Missense_Mutation_p.E1061K|PCDH9_ENST00000456367.1_Missense_Mutation_p.E1027K	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1061					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CTGCAGCTTTCCTGGGAGCCA	0.517000													27	40					0	0	1	0	0
PMPCA	23203	broad.mit.edu	37	9	139313499	139313499	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139313499C>T	ENST00000371717.3	+	11	1213	c.1204C>T	c.(1204-1206)Cga>Tga	p.R402*	PMPCA_ENST00000399219.3_Nonsense_Mutation_p.R271*|PMPCA_ENST00000462616.1_3'UTR	NM_015160.1	NP_055975.1	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	402					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|urinary_tract(1)	14		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		TTCGCAGGTTCGAGAAATGGT	0.567000													18	96					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78340139	78340139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78340139C>T	ENST00000255189.3	-	6	1010	c.982G>A	c.(982-984)Gga>Aga	p.G328R	DMGDH_ENST00000380311.4_Missense_Mutation_p.G127R|DMGDH_ENST00000540686.1_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	328					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		GGAGGAACTCCATTGGTGACC	0.458000													41	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9000453	9000453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9000453G>A	ENST00000397910.4	-	54	40734	c.40531C>T	c.(40531-40533)Ctt>Ttt	p.L13511F	MUC16_ENST00000380951.5_Missense_Mutation_p.L152F	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13513	SEA 10.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGACCCTGAAGGACTCTCTCC	0.488000													21	75					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3788206	3788206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:3788206G>A	ENST00000440314.2	-	6	872	c.399C>T	c.(397-399)gcC>gcT	p.A133A	EFCAB4B_ENST00000444507.1_Silent_p.A133A|EFCAB4B_ENST00000252322.1_Silent_p.A133A	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	133					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			CATGGCGCTGGGCCACCTGTT	0.557000													15	95					0	0	1	0	0
OR4D6	219983	broad.mit.edu	37	11	59224523	59224523	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59224523C>T	ENST00000300127.2	+	1	113	c.90C>T	c.(88-90)gtC>gtT	p.V30V		NM_001004708.1	NP_001004708.1	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D, member 6	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	34						TGTTTGTGGTCTTCTTTGCTG	0.463000													41	120					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	20959375	20959375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20959375G>A	ENST00000298925.5	+	11	1278	c.1125G>A	c.(1123-1125)cgG>cgA	p.R375R	NELL1_ENST00000357134.5_Silent_p.R347R|NELL1_ENST00000325319.5_Silent_p.R290R|NELL1_ENST00000532434.1_Silent_p.R347R			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	347	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						AAGGCCAGCGGATTTTAACCA	0.408000													29	78					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73043525	73043525	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73043525C>T	ENST00000604411.1	+	0	31486				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TTTTCCATCTCCTCAATCAGG	0.408000													42	87					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580471	140580471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580471C>T	ENST00000354757.3	+	1	1124	c.1124C>T	c.(1123-1125)tCt>tTt	p.S375F	PCDHB11_ENST00000536699.1_Missense_Mutation_p.S10F	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		375	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATATAGACTCTGGGGACAAC	0.428000													32	110					0	0	1	0	0
WDR43	23160	broad.mit.edu	37	2	29135488	29135488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29135488C>T	ENST00000407426.3	+	4	574	c.518C>T	c.(517-519)tCc>tTc	p.S173F		NM_015131.1	NP_055946.1	Q15061	WDR43_HUMAN	WD repeat domain 43	173						nucleolus				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	20	Acute lymphoblastic leukemia(172;0.155)					AGTGTCAGTTCCCTATGTATC	0.398000													32	59					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4829654	4829654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4829654G>A	ENST00000354582.6	+	51	6944	c.6594G>A	c.(6592-6594)atG>atA	p.M2198I	ITPR1_ENST00000456211.2_Missense_Mutation_p.M2150I|ITPR1_ENST00000443694.2_Missense_Mutation_p.M2198I|ITPR1_ENST00000423119.2_Missense_Mutation_p.M2165I|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.M2165I|ITPR1_ENST00000302640.8_Missense_Mutation_p.M2198I			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2213					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ACCGAACAATGGAACAGATAG	0.383000													6	20					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55032413	55032413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55032413G>A	ENST00000417545.2	+	2	168	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	12						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						CTTCCAGAGGGAACTCACCTG	0.483000													89	67					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114202624	114202624	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:114202624C>T	ENST00000434316.2	+	12	2136	c.1777C>T	c.(1777-1779)Ctg>Ttg	p.L593L	TMCO3_ENST00000375391.1_Intron	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	593						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GCAGTTTCTCCTGGCGGCGCT	0.557000													18	64					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79693265	79693265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:79693265G>A	ENST00000261205.4	+	8	1401	c.744G>A	c.(742-744)atG>atA	p.M248I	SYT1_ENST00000552744.1_Missense_Mutation_p.M248I|SYT1_ENST00000393240.3_Missense_Mutation_p.M248I|SYT1_ENST00000457153.2_Missense_Mutation_p.M245I	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	248	Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						AAGTCCCTATGAACACAGTGG	0.418000													39	125					0	0	1	0	0
TMEM202	338949	broad.mit.edu	37	15	72698948	72698948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72698948C>T	ENST00000341689.3	+	3	397	c.343C>T	c.(343-345)Ctc>Ttc	p.L115F	TMEM202_ENST00000567679.1_Silent_p.I29I	NM_001080462.1	NP_001073931.1	A6NGA9	TM202_HUMAN	transmembrane protein 202	115						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	18						TGCAGATTATCTCCAATATTC	0.453000													17	123					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28648063	28648063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28648063C>T	ENST00000280904.6	-	16	3067	c.2624G>A	c.(2623-2625)cGa>cAa	p.R875Q	DSC2_ENST00000251081.6_3'UTR	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	875					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTCTTCTTGTCGTTCACTGCA	0.413000													33	79					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762058	92762058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92762058C>T	ENST00000318238.4	-	5	4443	c.3227G>A	c.(3226-3228)aGa>aAa	p.R1076K	SAMD9L_ENST00000411955.1_Missense_Mutation_p.R1076K|SAMD9L_ENST00000437805.1_Missense_Mutation_p.R1076K	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1076										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGGGAATCGTCTACTTCCTGC	0.428000													56	132					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4883992	4883992	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:4883992G>A	ENST00000298375.7	+	7	767	c.696G>A	c.(694-696)ctG>ctA	p.L232L	AKR1E2_ENST00000525281.1_Intron|AKR1E2_ENST00000532248.1_Intron|AKR1E2_ENST00000334019.4_Intron|AKR1E2_ENST00000345253.5_Intron	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	232						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						GGGTTGACCTGATAGACAACC	0.517000													9	23					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809042	18809042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18809042C>T	ENST00000400664.1	+	1	1619	c.1567C>T	c.(1567-1569)Cgc>Tgc	p.R523C		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	523						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCGCTGGCTCGCATGCCCCC	0.672000													38	100					0	0	1	0	0
PKP3	11187	broad.mit.edu	37	11	397183	397183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:397183G>A	ENST00000331563.2	+	3	758	c.682G>A	c.(682-684)Ggg>Agg	p.G228R		NM_007183.2	NP_009114.1	Q9Y446	PKP3_HUMAN	plakophilin 3	228					cell adhesion	desmosome|nucleus	binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGGGCAGGGGGGCTGGACTG	0.711000													21	31					0	0	1	0	0
GPX3	2878	broad.mit.edu	37	5	150404937	150404937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150404937G>A	ENST00000388825.4	+	2	216	c.124G>A	c.(124-126)Gag>Aag	p.E42K	GPX3_ENST00000521722.1_3'UTR|GPX3_ENST00000517973.1_Intron	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	42					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CACCATTTACGAGTACGGAGC	0.512000													26	74					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123504887	123504887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123504887C>T	ENST00000392770.2	-	5	1414	c.612G>A	c.(610-612)gaG>gaA	p.E204E	SCN3B_ENST00000530277.1_Silent_p.E204E|SCN3B_ENST00000299333.3_Silent_p.E204E	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	204					axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		TCTCCTTGTTCTCAGATGGGA	0.537000													18	42					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139629193	139629193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139629193C>T	ENST00000303045.6	-	54	4280	c.3834G>A	c.(3832-3834)aaG>aaA	p.K1278K	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Silent_p.K1258K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1278	Collagen-like 12.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTGTGTGTCCCTTGAAGCCCT	0.587000										HNSCC(7;0.00092)			15	69					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117245	20117245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20117245G>A	ENST00000397165.2	-	4	1226	c.1066C>T	c.(1066-1068)Ctt>Ttt	p.L356F	ZNF682_ENST00000595736.1_Missense_Mutation_p.L280F|ZNF682_ENST00000597972.1_Missense_Mutation_p.L362F|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000397162.1_Missense_Mutation_p.L324F|ZNF682_ENST00000358523.5_Missense_Mutation_p.L324F	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TGTTCAGTAAGAATTGATGAT	0.368000													21	55					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124352006	124352006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124352006G>A	ENST00000338354.3	+	20	2501	c.2395G>A	c.(2395-2397)Gat>Aat	p.D799N	DMBT1_ENST00000344338.3_Missense_Mutation_p.D789N|DMBT1_ENST00000368955.3_Missense_Mutation_p.D789N|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368909.3_Missense_Mutation_p.D799N			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	799	SRCR 6.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGTTCTGGATGATGTGCGCTG	0.607000													25	231					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94933697	94933697	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94933697G>A	ENST00000337425.5	-	3	779	c.705C>T	c.(703-705)caC>caT	p.H235H	SERPINA9_ENST00000448305.2_Silent_p.H137H|SERPINA9_ENST00000424550.2_Silent_p.H86H|SERPINA9_ENST00000546329.1_Silent_p.H199H|SERPINA9_ENST00000380365.3_Silent_p.H217H|SERPINA9_ENST00000298845.7_Silent_p.H135H	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	217					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TATATTCAGGGTGAAAGGGCT	0.468000													15	35					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129470130	129470130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:129470130C>T	ENST00000421865.2	+	7	965	c.916C>T	c.(916-918)Cgc>Tgc	p.R306C		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	306	Laminin EGF-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTAGAAATCTCGCTGTGAGTG	0.418000													35	58					0	0	1	0	0
IGHV3-30	28439	broad.mit.edu	37	14	106791008	106791008	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106791008C>T	ENST00000390613.2	-	0	427																											CTGTGTCTCTCGCACAGTAAT	0.562000													73	551					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130934774	130934774	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130934774C>T	ENST00000261655.4	-	6	664	c.501G>A	c.(499-501)ggG>ggA	p.G167G	RIMBP2_ENST00000536002.1_Silent_p.G75G|RIMBP2_ENST00000535703.1_Silent_p.G75G	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	167	SH3 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGTGGACCTTCCCCGAGTATC	0.562000													4	25					0	0	1	0	0
LCE3E	353145	broad.mit.edu	37	1	152538680	152538680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152538680G>A	ENST00000368789.1	-	2	60	c.5C>T	c.(4-6)tCc>tTc	p.S2F		NM_178435.2	NP_848522.1	Q5T5B0	LCE3E_HUMAN	late cornified envelope 3E	2					keratinization					lung(6)|ovary(1)	7	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		Lung(1;0.000294)|LUAD - Lung adenocarcinoma(1;0.00527)|LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)		CTGCTGGCAGGACATCTTGGC	0.542000													23	55					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38156645	38156645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38156645G>A	ENST00000379747.4	-	10	1367	c.1250C>T	c.(1249-1251)aCt>aTt	p.T417I	POSTN_ENST00000379749.4_Missense_Mutation_p.T417I|POSTN_ENST00000541481.1_Missense_Mutation_p.T417I|POSTN_ENST00000541179.1_Missense_Mutation_p.T417I|POSTN_ENST00000379743.4_Missense_Mutation_p.T417I|POSTN_ENST00000379742.4_Missense_Mutation_p.T417I	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	417	FAS1 3.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CATGCTGAGAGTATCATCTGT	0.333000													15	52					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5754219	5754219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5754219C>T	ENST00000381624.3	+	13	1302	c.1241C>T	c.(1240-1242)tCg>tTg	p.S414L	CATSPERD_ENST00000309164.7_3'UTR|CATSPERD_ENST00000381614.2_Missense_Mutation_p.S72L	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	414						integral to membrane											TTGACTGCTTCGTTGATACCC	0.453000													64	138					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53519078	53519078	+	Silent	SNP	G	G	A	rs138040011		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:53519078G>A	ENST00000370905.3	-	2	1133	c.993C>T	c.(991-993)tcC>tcT	p.S331S	KLHL31_ENST00000407079.1_Silent_p.S331S	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					CTCTGCTAAGGGACTTCTCAG	0.488000													41	89					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8486289	8486289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8486289C>T	ENST00000447869.1	-	3	1338	c.420G>A	c.(418-420)acG>acA	p.T140T	STK33_ENST00000396673.1_Silent_p.T140T|STK33_ENST00000315204.1_Silent_p.T140T|STK33_ENST00000396672.1_Silent_p.T140T|STK33_ENST00000358872.3_5'UTR|STK33_ENST00000534493.1_Silent_p.T99T			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	140	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		TTGCCCACTTCGTTTCTGTTT	0.413000													51	84					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153652206	153652206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153652206C>T	ENST00000368680.3	+	1	1094	c.622C>T	c.(622-624)Cgc>Tgc	p.R208C		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	208					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CATGCGGGTCCGCGACCGCCT	0.657000													4	18					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76900452	76900452	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76900452C>T	ENST00000409709.3	+	28	3839	c.3567C>T	c.(3565-3567)gcC>gcT	p.A1189A	MYO7A_ENST00000409619.2_Silent_p.A1178A|MYO7A_ENST00000458637.2_Silent_p.A1189A	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1189	MyTH4 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCAGCTATGCCCGGGGCTGGA	0.622000													29	55					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64595811	64595811	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:64595811C>T	ENST00000536360.1	-	10	2184		c.e10+1					Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		AGATTACTTACTCTAGAAAGC	0.413000													23	57					0	0	1	0	0
STAC3	246329	broad.mit.edu	37	12	57642935	57642935	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57642935C>T	ENST00000332782.2	-	3	424	c.223G>A	c.(223-225)Gag>Aag	p.E75K	STAC3_ENST00000554578.1_Missense_Mutation_p.E36K|STAC3_ENST00000546246.2_Intron	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	75	Poly-Glu.				intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						GGTGGctcctcctcctcctct	0.552000													30	64					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73405711	73405711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73405711G>A	ENST00000224721.6	+	12	1284	c.1279G>A	c.(1279-1281)Gag>Aag	p.E427K	CDH23_ENST00000299366.7_Missense_Mutation_p.E467K|CDH23_ENST00000398809.4_Missense_Mutation_p.E422K|CDH23_ENST00000461841.3_Missense_Mutation_p.E467K|CDH23_ENST00000398842.3_Missense_Mutation_p.E422K	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	422	Cadherin 4.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACTGGACTACGAGACCGTGGA	0.592000													22	50					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160843796	160843796	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160843796G>A	ENST00000283243.7	-	12	2114	c.1908C>T	c.(1906-1908)caC>caT	p.H636H	PLA2R1_ENST00000392771.1_Silent_p.H636H	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	636	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						TTGCCTTAAAGTGCCGACAGT	0.483000													7	40					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83933329	83933329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83933329C>T	ENST00000345382.2	-	4	759	c.674G>A	c.(673-675)gGa>gAa	p.G225E	BNC1_ENST00000569704.1_Missense_Mutation_p.G218E|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	225					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						GCTGGGGTTTCCTTTGTCCAC	0.498000													51	153					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38990558	38990558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38990558G>A	ENST00000355481.4	+	45	7356	c.7225G>A	c.(7225-7227)Gaa>Aaa	p.E2409K	RYR1_ENST00000359596.3_Missense_Mutation_p.E2409K|RYR1_ENST00000360985.3_Missense_Mutation_p.E2409K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2409	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTTTGGTGAGGAACCGCCTGA	0.632000													36	93					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11648272	11648272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11648272C>T	ENST00000262442.3	+	31	6338	c.6270C>T	c.(6268-6270)ttC>ttT	p.F2090F	DNAH9_ENST00000454412.2_Silent_p.F2090F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2090					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCCCATCTTCATGGGCCTGA	0.572000													19	23					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109284406	109284406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109284406G>A	ENST00000370017.3	+	12	2459	c.2182G>A	c.(2182-2184)Ggg>Agg	p.G728R	FNDC7_ENST00000271311.2_Missense_Mutation_p.G729R	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	729						extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GATTTATAGAGGGAAGAGAAA	0.348000													13	44					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51375642	51375642	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51375642G>A	ENST00000216392.7	-	18	2541	c.2209C>T	c.(2209-2211)Cca>Tca	p.P737S	PYGL_ENST00000544180.2_Missense_Mutation_p.P703S|PYGL_ENST00000532462.1_Missense_Mutation_p.P737S	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	737					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TTCAGCTCTGGAAGTGCCTCA	0.418000													37	113					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98299547	98299547	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98299547G>A	ENST00000264193.2	-	7	1563	c.1345C>T	c.(1345-1347)Cca>Tca	p.P449S		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	449						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CAGTCCCTTGGATGGCGTAGA	0.512000													17	45					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21992957	21992957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21992957G>A	ENST00000327430.3	-	2	1199	c.905C>T	c.(904-906)cCt>cTt	p.P302L	SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron|SALL2_ENST00000450879.2_Missense_Mutation_p.P165L	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	302							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GGCTGGGGAAGGGGCAGGGGT	0.612000													15	29					0	0	1	0	0
CA5A	763	broad.mit.edu	37	16	87936081	87936081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:87936081C>T	ENST00000309893.2	-	4	570	c.505G>A	c.(505-507)Gaa>Aaa	p.E169K		NM_001739.1	NP_001730.1	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial	169					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding			large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(80;0.0513)		ACGACAGCTTCCTTGTAATTT	0.393000													26	49					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61623180	61623180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61623180G>A	ENST00000583023.1	+	14	2913	c.2902G>A	c.(2902-2904)Gaa>Aaa	p.E968K	KCNH6_ENST00000581784.1_Missense_Mutation_p.E879K|KCNH6_ENST00000456941.2_Missense_Mutation_p.E879K|KCNH6_ENST00000314672.5_Missense_Mutation_p.E932K	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	968					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CTCCCTCCCTGAACACCTTGG	0.562000													32	77					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10468411	10468411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10468411G>A	ENST00000529370.1	-	17	2825	c.2495C>T	c.(2494-2496)cCc>cTc	p.P832L	TYK2_ENST00000264818.6_Intron|TYK2_ENST00000525621.1_Intron|TYK2_ENST00000524462.1_Intron			P29597	TYK2_HUMAN	tyrosine kinase 2	0	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCCCACTGCGGGGAGGGCCCA	0.612000													6	5					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759380	121759380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121759380G>A	ENST00000261367.7	+	6	2517	c.1089G>A	c.(1087-1089)ctG>ctA	p.L363L	SNCAIP_ENST00000261368.8_Silent_p.L316L|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000379536.2_Silent_p.L316L|SNCAIP_ENST00000503116.2_Silent_p.L363L|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000379533.2_Silent_p.L363L			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	316					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GTGAGTATCTGAAAAAAGTGA	0.443000													13	96					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43753252	43753252	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:43753252C>T	ENST00000458276.2	+	4	681	c.558C>T	c.(556-558)gaC>gaT	p.D186D		NM_016006.4	NP_057090.2	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	186					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			kidney(3)|large_intestine(2)|liver(2)|lung(5)|ovary(1)|skin(1)	14		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		AACGACCAGACCTTGCTGATC	0.453000													46	103					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108175647	108175647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108175647G>A	ENST00000273353.3	-	20	2220	c.2164C>T	c.(2164-2166)Cca>Tca	p.P722S	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	722	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AGTCGGTTTGGAAAACCTTCA	0.438000													13	178					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156498719	156498719	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156498719G>A	ENST00000361170.2	-	35	4570	c.4560C>T	c.(4558-4560)gcC>gcT	p.A1520A		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1520					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGAGTCGGGGGCCAGGTGGT	0.572000													17	69					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169539934	169539934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169539934C>T	ENST00000340806.6	+	1	225	c.225C>T	c.(223-225)gtC>gtT	p.V75V		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	75										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ACATCAGGGTCCTCTACCTGG	0.502000													40	82					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113637901	113637901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113637901G>A	ENST00000374431.3	-	5	1278	c.895C>T	c.(895-897)Ctt>Ttt	p.L299F	LPAR1_ENST00000538760.1_Missense_Mutation_p.L300F|LPAR1_ENST00000541779.1_Missense_Mutation_p.L300F|LPAR1_ENST00000374430.2_Missense_Mutation_p.L299F|LPAR1_ENST00000358883.4_Missense_Mutation_p.L299F	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	299					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						AATTCAGCAAGGAGAAGGAAG	0.502000													38	87					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43757787	43757787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43757787C>T	ENST00000270077.3	-	6	1351	c.1255G>A	c.(1255-1257)Gga>Aga	p.G419R	PSG9_ENST00000593948.1_Missense_Mutation_p.G326R|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000443718.3_Missense_Mutation_p.G326R|PSG9_ENST00000291752.5_Missense_Mutation_p.G233R	NM_002784.3	NP_002775.3	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	419					female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				gtcaggtctccatggcaggga	0.453000													7	105					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94845910	94845910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94845910C>T	ENST00000448921.1	-	6	1528	c.956G>A	c.(955-957)gGa>gAa	p.G319E	SERPINA1_ENST00000393088.4_Missense_Mutation_p.G319E|SERPINA1_ENST00000437397.1_Missense_Mutation_p.G319E|SERPINA1_ENST00000355814.4_Missense_Mutation_p.G319E|SERPINA1_ENST00000404814.4_Missense_Mutation_p.G319E|SERPINA1_ENST00000393087.4_Missense_Mutation_p.G319E|SERPINA1_ENST00000402629.1_Missense_Mutation_p.G319E|SERPINA1_ENST00000449399.3_Missense_Mutation_p.G319E|SERPINA1_ENST00000440909.1_Missense_Mutation_p.G319E	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	319					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity	p.G319V(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	ATCATAGGTTCCAGTAATGGA	0.522000													13	137					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110788861	110788861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110788861C>T	ENST00000327908.3	+	3	869	c.105C>T	c.(103-105)gtC>gtT	p.V35V	LRIT3_ENST00000594814.1_Silent_p.V218V|LRIT3_ENST00000409621.2_Silent_p.V35V|LRIT3_ENST00000379920.3_Silent_p.V173V			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	173						integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TGTCAAAGGTCGTTGACCCTG	0.443000													26	78					0	0	1	0	0
IFLTD1	160492	broad.mit.edu	37	12	25699359	25699359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25699359G>A	ENST00000539744.1	-	4	565	c.86C>T	c.(85-87)aCt>aTt	p.T29I	IFLTD1_ENST00000445693.1_Missense_Mutation_p.T63I|IFLTD1_ENST00000458174.2_Missense_Mutation_p.T147I|IFLTD1_ENST00000413632.2_Missense_Mutation_p.T147I|IFLTD1_ENST00000282881.6_Missense_Mutation_p.T126I	NM_001256266.1	NP_001243195.1	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	126						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					GTATTTTAAAGTTTTCTGAGT	0.363000													23	61					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75265490	75265490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75265490C>T	ENST00000325680.7	+	5	3614	c.3490C>T	c.(3490-3492)Cgt>Tgt	p.R1164C	YLPM1_ENST00000238571.3_Missense_Mutation_p.R969C|YLPM1_ENST00000552421.1_Intron	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	969	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck		p.R969C(1)|p.R1164C(1)		breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGATTTTGGTCGTGATAGAGG	0.542000													8	55					0	0	1	0	0
WDR75	84128	broad.mit.edu	37	2	190328438	190328438	+	Missense_Mutation	SNP	G	G	A	rs144965982		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:190328438G>A	ENST00000314761.4	+	10	1016	c.956G>A	c.(955-957)cGa>cAa	p.R319Q		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	319						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			ATTATTCACCGAAACCTTGAA	0.368000													38	81					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167045758	167045758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167045758C>T	ENST00000392766.2	-	11	1174	c.834G>A	c.(832-834)aaG>aaA	p.K278K	ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Silent_p.K249K|ZBBX_ENST00000455345.2_Silent_p.K278K|ZBBX_ENST00000392767.2_Silent_p.K278K|ZBBX_ENST00000307529.5_Silent_p.K278K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	278						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AATTCTGTTTCTTGTTGTCAT	0.418000													50	91					0	0	1	0	0
TGFB2	7042	broad.mit.edu	37	1	218609363	218609363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:218609363C>T	ENST00000366929.4	+	6	1357	c.890C>T	c.(889-891)tCc>tTc	p.S297F	TGFB2_ENST00000479322.1_3'UTR|TGFB2_ENST00000366930.4_Missense_Mutation_p.S269F	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	269					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		ACTATAAAGTCCACTAGGAAA	0.423000													39	77					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27204092	27204092	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:27204092G>A	ENST00000429845.2	-	32	3232	c.2869_splice	c.e32-1	p.A957_splice	NEK10_ENST00000498182.1_Intron|NEK10_ENST00000383771.4_Splice_Site_p.A269_splice|NEK10_ENST00000357467.2_Splice_Site_p.A354_splice|NEK10_ENST00000383770.3_Intron|NEK10_ENST00000295720.6_Splice_Site_p.A269_splice			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	957							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AGGCAGCAAAGCTGAAGAAAT	0.418000													17	58					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71631932	71631932	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71631932C>T	ENST00000356340.3	+	3	901	c.364_splice	c.e3-1	p.A122_splice	COL13A1_ENST00000517713.1_Intron|COL13A1_ENST00000398973.3_Intron|COL13A1_ENST00000398972.3_Intron|COL13A1_ENST00000357811.3_Intron|COL13A1_ENST00000398966.3_Splice_Site_p.A122_splice|COL13A1_ENST00000522165.1_Intron|COL13A1_ENST00000398971.3_Splice_Site_p.A122_splice|COL13A1_ENST00000520133.1_Intron|COL13A1_ENST00000520267.1_Intron|COL13A1_ENST00000398968.3_Splice_Site_p.A122_splice|COL13A1_ENST00000398978.3_Intron|COL13A1_ENST00000398974.3_Splice_Site_p.A122_splice|COL13A1_ENST00000398964.3_Splice_Site_p.A122_splice|COL13A1_ENST00000354547.3_Intron|COL13A1_ENST00000398969.3_Intron			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	122	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	CGTCACTCTTCATTTCAGGGT	0.483000													13	39					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99917221	99917221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99917221G>A	ENST00000332397.6	+	9	1564	c.1380G>A	c.(1378-1380)gaG>gaA	p.E460E	SPDYE3_ENST00000437326.2_Silent_p.E83E	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	460										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						AGGACGACGAGGCCCCCAAAC	0.552000													48	90					0	0	1	0	0
RASL11A	387496	broad.mit.edu	37	13	27847352	27847352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:27847352C>T	ENST00000241463.4	+	4	1068	c.450C>T	c.(448-450)gaC>gaT	p.D150D	RASL11A_ENST00000480803.1_3'UTR	NM_206827.1	NP_996563.1	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	150	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	10		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		ACAAGGGGGACCTTTTGCATG	0.532000													19	42					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45242109	45242109	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45242109G>A	ENST00000279027.4	-	2	385	c.367C>T	c.(367-369)Cag>Tag	p.Q123*	SLC13A3_ENST00000472148.1_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000396360.1_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000372121.1_Nonsense_Mutation_p.Q123*|SLC13A3_ENST00000495082.1_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000339636.3_Nonsense_Mutation_p.Q123*|SLC13A3_ENST00000417157.2_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000435032.1_5'UTR|SLC13A3_ENST00000290317.5_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000413164.2_Nonsense_Mutation_p.Q123*	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	123						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CTGGCCGGCTGGACTCCAACA	0.562000													19	49					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46832728	46832728	+	Missense_Mutation	SNP	C	C	T	rs140829009		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46832728C>T	ENST00000339613.2	+	12	1792	c.1537C>T	c.(1537-1539)Cgg>Tgg	p.R513W	AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000300862.3_Missense_Mutation_p.R567W|HIF3A_ENST00000244303.6_Missense_Mutation_p.R500W|HIF3A_ENST00000420102.2_Missense_Mutation_p.R518W|HIF3A_ENST00000377670.4_Missense_Mutation_p.R569W|HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000600383.1_Missense_Mutation_p.R500W			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	569	ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GGCTGGGGCTCGGAAGAGGTG	0.652000													6	10					0	0	1	0	0
FITM1	161247	broad.mit.edu	37	14	24600934	24600934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24600934C>T	ENST00000558325.1	+	3	724	c.724C>T	c.(724-726)Cct>Tct	p.242_242insS	FITM1_ENST00000267426.5_Silent_p.R54R																							GCTTACGGCGCCTCTACCATG	0.617000													22	58					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255615	15255615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15255615G>A	ENST00000378116.4	-	8	1978	c.1972C>T	c.(1972-1974)Cct>Tct	p.P658S		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	658						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GCGTTCTGAGGGCTCCACTCC	0.607000													19	71					0	0	1	0	0
CORO2A	7464	broad.mit.edu	37	9	100890474	100890474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:100890474C>T	ENST00000343933.5	-	10	1406	c.1149G>A	c.(1147-1149)gaG>gaA	p.E383E	CORO2A_ENST00000375077.4_Silent_p.E383E	NM_003389.3	NP_003380.3	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	383					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|skin(4)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				CGCTGAGCCACTCCTGGGCCG	0.592000													96	271					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237791147	237791147	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237791147G>A	ENST00000366574.2	+	41	6524	c.6207G>A	c.(6205-6207)tgG>tgA	p.W2069*	RYR2_ENST00000542537.1_Nonsense_Mutation_p.W2053*|RYR2_ENST00000360064.6_Nonsense_Mutation_p.W2067*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2069	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGTCCGATGGGCTCAGGAGT	0.493000													6	25					0	0	1	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841548	8841548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8841548C>T	ENST00000324060.2	+	1	233	c.158C>T	c.(157-159)tCc>tTc	p.S53F		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CGTGTGGACTCCCGGCTCCAT	0.547000													44	114					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15290705	15290705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15290705G>A	ENST00000378116.4	-	5	693	c.687C>T	c.(685-687)ccC>ccT	p.P229P	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	229						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GCGTGGCCAGGGGCACAGTGA	0.602000													26	83					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17405782	17405782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17405782G>A	ENST00000375486.4	-	11	1350	c.1287C>T	c.(1285-1287)atC>atT	p.I429I	PADI2_ENST00000466151.1_5'UTR|PADI2_ENST00000375481.1_Silent_p.I429I|PADI2_ENST00000444885.2_Silent_p.I313I	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	429					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TCCCGATGAGGATGCGGCCAA	0.582000													14	51					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101295478	101295478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101295478G>A	ENST00000538618.1	+	4	413	c.413G>A	c.(412-414)cGa>cAa	p.R138Q	ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000392977.3_5'UTR|ANO4_ENST00000299222.9_5'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CATCAACGGCGAAGTGTGGCA	0.498000										HNSCC(74;0.22)			24	49					0	0	1	0	0
TRBV11-2	28581	broad.mit.edu	37	7	142198025	142198025	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142198025G>A	ENST00000471935.1	-	0	44																											GTCAGGGAAGGATGGGAGCTT	0.577000													21	58					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25766052	25766052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:25766052G>A	ENST00000520164.1	-	7	1108	c.571C>T	c.(571-573)Ctc>Ttc	p.L191F	EBF2_ENST00000408929.3_Missense_Mutation_p.L43F	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	191					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TTGCACTTGAGGAAAAATTTT	0.363000													7	66					0	0	1	0	0
CDK9	1025	broad.mit.edu	37	9	130550648	130550648	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130550648C>T	ENST00000373265.2	+	5	939	c.939C>T	c.(937-939)ccC>ccT	p.P313P	CDK9_ENST00000480353.1_3'UTR|CDK9_ENST00000373264.4_Silent_p.P196P			P50750	CDK9_HUMAN	cyclin-dependent kinase 9	196	Protein kinase.				cell proliferation|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription elongation factor complex	ATP binding|cyclin-dependent protein kinase activity|DNA binding|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(1)	1						GGTACCGGCCCCCGGAGCTGT	0.667000													6	17					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36212573	36212573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36212573C>T	ENST00000420124.1	+	3	2324	c.2324C>T	c.(2323-2325)gCc>gTc	p.A775V	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Missense_Mutation_p.A775V																							CTGGAAAAAGCCCGGATTGCG	0.607000													6	25					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156811288	156811288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156811288G>A	ENST00000368195.3	-	21	3956	c.3560C>T	c.(3559-3561)aCc>aTc	p.T1187I	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	1187	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTCTGCCAGGGTCACAATCTC	0.612000													29	58					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36122870	36122870	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36122870C>T	ENST00000303965.4	-	23	4314	c.3825G>A	c.(3823-3825)acG>acA	p.T1275T		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1275	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTTGTCCCTTCGTTTGAAACA	0.338000													7	87					0	0	1	0	0
SLC35G2	80723	broad.mit.edu	37	3	136573671	136573671	+	Silent	SNP	G	G	A	rs142918857	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:136573671G>A	ENST00000446465.2	+	2	997	c.369G>A	c.(367-369)agG>agA	p.R123R	RP11-85F14.5_ENST00000474250.1_RNA|RP11-85F14.5_ENST00000470236.1_RNA|RP11-85F14.5_ENST00000461864.1_RNA|SLC35G2_ENST00000393079.3_Silent_p.R123R	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	123	DUF6 1.					Golgi apparatus|integral to membrane											TTATCACTAGGCTTGTTTCTG	0.393000													63	184					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69337234	69337234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69337234C>T	ENST00000305363.4	+	5	447	c.383C>T	c.(382-384)aCt>aTt	p.T128I		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	128	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TTTCACTCTACTGAGGATCCT	0.373000													87	234					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93098047	93098047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:93098047C>T	ENST00000359558.2	-	8	854	c.555G>A	c.(553-555)ctG>ctA	p.L185L	CALCR_ENST00000394441.1_Silent_p.L167L|CALCR_ENST00000421592.1_Silent_p.L167L|CALCR_ENST00000360249.4_Silent_p.L167L|CALCR_ENST00000426151.1_Silent_p.L167L	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	167					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CGAAAATCCCCAGGGAAATCA	0.383000													13	63					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632266	122632266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122632266G>A	ENST00000195173.4	-	17	2586	c.2283C>T	c.(2281-2283)ttC>ttT	p.F761F	SEMA5B_ENST00000451055.2_Silent_p.F816F|SEMA5B_ENST00000357599.3_Silent_p.F762F			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	762	TSP type-1 2.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		TGCACGTCTTGAACTCCTGCG	0.726000													5	10					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53663157	53663157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53663157C>T	ENST00000257934.4	+	3	522	c.431C>T	c.(430-432)gCt>gTt	p.A144V	ESPL1_ENST00000552462.1_Missense_Mutation_p.A144V	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	144					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						GAGGCCGTGGCTCGGGGCAGC	0.622000													35	48					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122853810	122853810	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122853810C>T	ENST00000264811.5	-	1	802	c.384G>A	c.(382-384)gcG>gcA	p.A128A	TRPC3_ENST00000379645.3_Silent_p.A201A|TRPC3_ENST00000513531.1_Silent_p.A128A	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	116					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCTTGCTGGCCGCGAAGCCAG	0.637000													7	35					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057917	63057917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63057917C>T	ENST00000332793.6	+	1	282	c.280C>T	c.(280-282)Ccc>Tcc	p.P94S	SLC22A10_ENST00000526800.1_Missense_Mutation_p.P42S|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_5'UTR	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	94						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTTTGTCCATCCCCAGTGGCA	0.488000													57	112					0	0	1	0	0
GIT1	28964	broad.mit.edu	37	17	27909760	27909760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:27909760G>A	ENST00000225394.3	-	4	609	c.361C>T	c.(361-363)Ccc>Tcc	p.P121S	GIT1_ENST00000581348.1_Missense_Mutation_p.P121S|GIT1_ENST00000394869.3_Missense_Mutation_p.P121S|RP11-68I3.2_ENST00000581474.1_RNA|GIT1_ENST00000579937.1_Missense_Mutation_p.P121S	NM_014030.3	NP_054749.2	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 1	121	Arf-GAP.			P -> S (in Ref. 1; AAD28046).	regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding			large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		TCCCGGCAGGGAAGCTTGTGC	0.587000													15	21					0	0	1	0	0
NENF	29937	broad.mit.edu	37	1	212619322	212619322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:212619322C>T	ENST00000366988.3	+	4	550	c.493C>T	c.(493-495)Cat>Tat	p.H165Y	NENF_ENST00000473900.1_3'UTR	NM_013349.4	NP_037481.1	Q9UMX5	NENF_HUMAN	neudesin neurotrophic factor	165						extracellular space	heme binding			endometrium(1)|kidney(1)|large_intestine(2)	4				all cancers(67;0.00967)|OV - Ovarian serous cystadenocarcinoma(81;0.0108)|GBM - Glioblastoma multiforme(131;0.0325)|Epithelial(68;0.132)		AGACCAGCCCCATTTTGACAT	0.522000													18	73					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60758262	60758262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60758262G>A	ENST00000303375.5	+	17	2977	c.2575G>A	c.(2575-2577)Gag>Aag	p.E859K		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	859	C-type lectin 5.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GTTCCAGGCCGAGCTGACCTC	0.642000													12	28					0	0	1	0	0
OR5AN1	390195	broad.mit.edu	37	11	59132522	59132522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59132522G>A	ENST00000313940.2	+	1	638	c.591G>A	c.(589-591)caG>caA	p.Q197Q		NM_001004729.1	NP_001004729.1	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN, member 1	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	21						TCTTTGTACAGGTCATGACTG	0.408000													55	113					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	122075625	122075625	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:122075625C>T	ENST00000265922.3	-	2	470	c.9G>A	c.(7-9)tgG>tgA	p.W3*	DBC1_ENST00000373964.2_Nonsense_Mutation_p.W3*	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		3					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CAACAAACCTCCAGTTCATGC	0.463000													10	41					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873228	55873228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55873228C>T	ENST00000313503.1	+	1	710	c.710C>T	c.(709-711)gCt>gTt	p.A237V		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					AAGCAGAAAGCTTTCTCTACT	0.388000										HNSCC(53;0.14)			26	101					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350254	51350254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51350254C>T	ENST00000327536.5	-	3	802	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	235										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		TGCACCAGTTCATGCACCAGG	0.552000													19	40					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169511128	169511128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169511128G>A	ENST00000367796.3	-	13	3416	c.3215C>T	c.(3214-3216)tCg>tTg	p.S1072L	F5_ENST00000367797.3_Missense_Mutation_p.S1067L			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1067	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AAGCACCAACGAATGCTTAAG	0.438000													63	298					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54299171	54299171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54299171C>T	ENST00000324134.6	-	9	3208	c.3040G>A	c.(3040-3042)Ggt>Agt	p.G1014S	NLRP12_ENST00000354278.3_Intron|NLRP12_ENST00000391772.1_Intron|NLRP12_ENST00000351894.4_Missense_Mutation_p.G902S|NLRP12_ENST00000391775.3_Missense_Mutation_p.G957S|NLRP12_ENST00000535162.1_Intron|NLRP12_ENST00000345770.5_Intron|NLRP12_ENST00000391773.1_Missense_Mutation_p.G1015S	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	1014					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGTCGGACACCTGTGTCCCCT	0.557000													10	47					0	0	1	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65714447	65714447	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65714447G>A	ENST00000532620.1	+	0	475							Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein											endometrium(2)|kidney(3)|lung(9)	14						CAAGCCCAGGGGCCAGAGCAA	0.612000													29	71					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73179425	73179425	+	Missense_Mutation	SNP	G	G	A	rs150168072		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73179425G>A	ENST00000286657.4	-	12	1750	c.1714C>T	c.(1714-1716)Cgt>Tgt	p.R572C		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	572	TSP type-1 1.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTTCTGAAACGAACACCAGTT	0.393000													13	43					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031330	79031330	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79031330G>A	ENST00000446378.2	+	2	6773	c.6742G>A	c.(6742-6744)Gaa>Aaa	p.E2248K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2248						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AACTGCTGATGAACCCAGAGG	0.348000													39	86					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488152	24488152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:24488152C>T	ENST00000264463.4	-	12	2494	c.1987G>A	c.(1987-1989)Gga>Aga	p.G663R	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	663					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G663*(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TCCTCCTCTCCACCACCCTCA	0.453000										HNSCC(23;0.051)			34	95					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3746449	3746449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3746449G>A	ENST00000378230.3	-	14	2273	c.1949C>T	c.(1948-1950)cCa>cTa	p.P650L		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	650						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						GCTGTCGTCTGGAGGAAGGTA	0.488000													22	171					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68424575	68424575	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68424575G>A	ENST00000265404.2	+	1	130	c.48G>A	c.(46-48)caG>caA	p.Q16Q	STAP1_ENST00000396225.1_Silent_p.Q16Q	NM_012108.2	NP_036240.1	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	16					cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						GGATCTTCCAGGAAAGGTTAA	0.423000													50	121					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447414	24447414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24447414G>A	ENST00000270800.1	-	7	1644	c.1606C>T	c.(1606-1608)Ctt>Ttt	p.L536F		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	536						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GGACACACAAGGGACTCCAGC	0.617000													6	77					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96051383	96051383	+	Silent	SNP	C	C	T	rs143402775		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96051383C>T	ENST00000297954.4	+	20	4458	c.4458C>T	c.(4456-4458)ctC>ctT	p.L1486L	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Silent_p.L1098L|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_Silent_p.L1061L|WNK2_ENST00000395477.2_Silent_p.L1449L			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1486					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TGCAGCCCCTCGTGGTGGGCC	0.677000													3	5					0	0	1	0	0
AQP9	366	broad.mit.edu	37	15	58430866	58430866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:58430866C>T	ENST00000219919.4	+	1	472	c.102C>T	c.(100-102)ttC>ttT	p.F34F	AQP9_ENST00000558772.1_Intron|ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000536493.1_Silent_p.F34F|AQP9_ENST00000559443.1_3'UTR	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9	34					cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		TGGGCACGTTCATCTTGATTG	0.453000													11	80					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975383	20975383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20975383C>T	ENST00000261383.3	-	53	9822	c.9823G>A	c.(9823-9825)Gag>Aag	p.E3275K	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3275	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTCTGTTTCTCTGAGATCTCT	0.478000													48	132					0	0	1	0	0
TPCN2	219931	broad.mit.edu	37	11	68835021	68835021	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68835021T>C	ENST00000294309.3	+	8	878	c.777T>C	c.(775-777)ccT>ccC	p.P259P	TPCN2_ENST00000542467.1_Silent_p.P259P|TPCN2_ENST00000442692.2_3'UTR	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	259					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AGAACCTGCCTGAGTCTCTGA	0.652000													28	78					0	0	1	0	0
HNRNPKP3	399881	broad.mit.edu	37	11	43283595	43283595	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:43283595G>A	ENST00000511537.1	-	0	1340					NR_033868.1																						TTTTTAAACAGAAGCAAATGT	0.388000													4	1					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71394475	71394475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:71394475G>A	ENST00000392650.3	-	23	3187	c.3187C>T	c.(3187-3189)Ccc>Tcc	p.P1063S	SDK2_ENST00000388726.3_Missense_Mutation_p.P1063S	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1063	Fibronectin type-III 5.				cell adhesion	integral to membrane		p.P1063S(1)		breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CAGGTGAAGGGGTTGAGGTCG	0.637000													23	82					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238277716	238277716	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238277716G>A	ENST00000295550.4	-	10	4842	c.4390C>T	c.(4390-4392)Cga>Tga	p.R1464*	COL6A3_ENST00000353578.4_Nonsense_Mutation_p.R1258*|COL6A3_ENST00000409809.1_Nonsense_Mutation_p.R1258*|COL6A3_ENST00000472056.1_Nonsense_Mutation_p.R857*|COL6A3_ENST00000346358.4_Nonsense_Mutation_p.R1264*|COL6A3_ENST00000347401.3_Nonsense_Mutation_p.R1263*	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1464	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.R1464*(1)		breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTGAGTCTTCGAACAATCCTG	0.473000													20	36					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933793	44933793	+	Missense_Mutation	SNP	C	C	T	rs148444351	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44933793C>T	ENST00000291187.4	-	6	1467	c.1145G>A	c.(1144-1146)cGa>cAa	p.R382Q	ZNF229_ENST00000588931.1_Missense_Mutation_p.R388Q|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GTTTGAACTTCGACCAAATGC	0.478000													13	175					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848367	73848367	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73848367G>A	ENST00000523207.1	+	3	1365	c.777G>A	c.(775-777)tgG>tgA	p.W259*		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	259					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CAAATAAATGGAAGTTCTTCA	0.453000													26	81					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155119159	155119159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:155119159G>A	ENST00000286448.6	+	2	195	c.30G>A	c.(28-30)agG>agA	p.R10R	VAMP7_ENST00000262640.6_Silent_p.R10R|VAMP7_ENST00000460621.1_Silent_p.R10R|VAMP7_ENST00000479687.1_3'UTR	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	10	Longin.				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTGTTGCCAGGGGGACCACTA	0.403000													46	112					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2022195	2022195	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2022195C>T	ENST00000382722.5	-	3	782	c.420G>A	c.(418-420)gcG>gcA	p.A140A	CACNA2D4_ENST00000585708.1_Silent_p.A76A|CACNA2D4_ENST00000587995.1_Silent_p.A140A|CACNA2D4_ENST00000586184.1_Silent_p.A140A|CACNA2D4_ENST00000585732.1_Silent_p.A140A|CACNA2D4_ENST00000588077.1_Silent_p.A76A	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	140						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GTACCTGGACCGCCTCGACTT	0.597000													4	19					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64390363	64390363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64390363G>A	ENST00000265459.6	-	21	4496	c.4035C>T	c.(4033-4035)tcC>tcT	p.S1345S	NRXN2_ENST00000377551.1_Silent_p.S1345S|NRXN2_ENST00000409571.1_Silent_p.S1338S|NRXN2_ENST00000377559.3_Silent_p.S1275S|NRXN2_ENST00000301894.2_Silent_p.S299S	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1345	Laminin G-like 6.				cell adhesion	integral to membrane	metal ion binding	p.S1345S(1)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TGAGCAGCACGGACGGCCCCT	0.672000													10	16					0	0	1	0	0
ZGPAT	84619	broad.mit.edu	37	20	62367218	62367218	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62367218C>A	ENST00000328969.5	+	7	1670	c.1543C>A	c.(1543-1545)Ctg>Atg	p.L515M	ZGPAT_ENST00000448100.1_Missense_Mutation_p.L495M|ZGPAT_ENST00000357119.4_Missense_Mutation_p.L486M|ZGPAT_ENST00000490623.1_3'UTR|ZGPAT_ENST00000355969.6_Missense_Mutation_p.L495M|ZGPAT_ENST00000369967.3_Missense_Mutation_p.L495M	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	515					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					GGAAGCCGGCCTGCAGCAGGA	0.652000													26	37					2.12542e-12	2.13544e-12	1	1	0
PHF20L1	51105	broad.mit.edu	37	8	133811053	133811053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133811053C>T	ENST00000395386.2	+	5	675	c.376C>T	c.(376-378)Cgt>Tgt	p.R126C	PHF20L1_ENST00000315808.10_Missense_Mutation_p.R126C|PHF20L1_ENST00000220847.7_5'UTR|PHF20L1_ENST00000337920.4_Missense_Mutation_p.R126C|PHF20L1_ENST00000395390.2_Missense_Mutation_p.R126C|PHF20L1_ENST00000395376.1_Missense_Mutation_p.R126C|PHF20L1_ENST00000395379.1_Missense_Mutation_p.R126C|PHF20L1_ENST00000395382.3_5'UTR|PHF20L1_ENST00000395383.1_Missense_Mutation_p.R126C	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	126	Tudor 2.						nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGGAGTAATTCGTTGTTTAAA	0.373000													8	22					0	0	1	0	0
MAPK10	5602	broad.mit.edu	37	4	87080462	87080462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:87080462C>T	ENST00000395169.3	-	4	831	c.111G>A	c.(109-111)caG>caA	p.Q37Q	MAPK10_ENST00000361569.2_Silent_p.Q75Q|MAPK10_ENST00000449047.2_5'UTR|MAPK10_ENST00000395161.2_Silent_p.Q75Q|MAPK10_ENST00000395166.1_Silent_p.Q37Q|MAPK10_ENST00000359221.3_Silent_p.Q75Q|RP11-778J15.1_ENST00000511917.1_RNA|MAPK10_ENST00000513839.1_5'UTR	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	75					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding	p.Q75H(1)		breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		AAACTATGCCCTGAGCCCCAG	0.448000													36	119					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46318912	46318912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46318912G>A	ENST00000245934.7	-	27	3975	c.3731C>T	c.(3730-3732)cCc>cTc	p.P1244L	SYMPK_ENST00000598155.1_5'UTR	NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	1244					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GAGGGTCTGGGGGCTCCGCTC	0.692000													5	17					0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138394383	138394383	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138394383G>A	ENST00000310018.2	-	21	2697	c.2415C>T	c.(2413-2415)gcC>gcT	p.A805A	ATP6V0A4_ENST00000353492.4_Silent_p.A805A|ATP6V0A4_ENST00000393054.1_Silent_p.A805A	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	805					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GCAGTCGCAGGGCGTGCAGGA	0.552000													83	212					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340705	121340705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121340705G>A	ENST00000338040.4	+	3	843	c.429G>A	c.(427-429)atG>atA	p.M143I		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	143					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		CCTTGAAAATGGTGGAACTTT	0.507000													11	34					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54554694	54554694	+	Missense_Mutation	SNP	C	C	T	rs147285202	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54554694C>T	ENST00000338372.2	-	4	539	c.364G>A	c.(364-366)Gat>Aat	p.D122N	VSTM1_ENST00000366170.2_Missense_Mutation_p.D34N|VSTM1_ENST00000425006.2_Missense_Mutation_p.D122N|VSTM1_ENST00000376626.1_Missense_Mutation_p.D122N	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	122						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TCAAGTTCATCGTGTTTATCT	0.393000													14	27					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156589787	156589787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156589787G>A	ENST00000302938.4	-	2	1584	c.1489C>T	c.(1489-1491)Cgc>Tgc	p.R497C		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	497						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGCTCTTGCGAGAGGAGCCA	0.502000													13	148					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95604975	95604975	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95604975G>A	ENST00000343958.4	-	2	308	c.85C>T	c.(85-87)Cct>Tct	p.P29S	FGD6_ENST00000546711.1_Missense_Mutation_p.P29S|FGD6_ENST00000549499.1_Missense_Mutation_p.P29S	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	29					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						GGTGCAATAGGAGGTGGGGCT	0.428000													89	163					0	0	1	0	0
PTAFR	5724	broad.mit.edu	37	1	28477113	28477113	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28477113G>A	ENST00000373857.3	-	2	1054	c.420C>T	c.(418-420)gtC>gtT	p.V140V	PTAFR_ENST00000305392.3_Silent_p.V140V|PTAFR_ENST00000539896.1_Silent_p.V140V	NM_000952.4|NM_001164722.2|NM_001164723.2	NP_000943.1|NP_001158194.1|NP_001158195.1	P25105	PTAFR_HUMAN	platelet-activating factor receptor	140					chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|stomach(1)	15		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCCAGATGACCAAGGACA	0.577000													29	86					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66883549	66883549	+	Silent	SNP	G	G	A	rs142750568		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66883549G>A	ENST00000269080.2	-	23	3260	c.3123C>T	c.(3121-3123)ttC>ttT	p.F1041F	ABCA8_ENST00000586539.1_Silent_p.F1081F|ABCA8_ENST00000430352.2_Silent_p.F1081F	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1041						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					ATATAAAAACGAAGACCAAGA	0.413000													53	210					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	71535217	71535217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71535217C>T	ENST00000355327.3	+	5	828	c.694C>T	c.(694-696)Cgc>Tgc	p.R232C	THSD4_ENST00000261862.6_Missense_Mutation_p.R232C			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	232	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CAGTGGCCCTCGCTCTGGACT	0.577000													22	99					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201351789	201351789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201351789C>T	ENST00000391967.2	-	8	1766	c.1465G>A	c.(1465-1467)Gac>Aac	p.D489N	LAD1_ENST00000367313.3_Missense_Mutation_p.D503N	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	489						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						ACCTGGGGGTCCTGATCTCCA	0.542000													9	13					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39880407	39880407	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39880407G>C	ENST00000260356.5	+	9	1624	c.1459G>C	c.(1459-1461)Gac>Cac	p.D487H		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	487	TSP type-1 2.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CTGCAAGAAAGACGCCTGCCC	0.612000													22	44					0	0	1	0	0
POU2F3	25833	broad.mit.edu	37	11	120188070	120188070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120188070C>T	ENST00000260264.4	+	12	1308	c.1274C>T	c.(1273-1275)tCa>tTa	p.S425L	POU2F3_ENST00000543440.2_Missense_Mutation_p.S423L	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	423	Ser-rich.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		TTTAACTCTTCAGGGTAAGGT	0.532000													28	78					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81697726	81697726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81697726C>T	ENST00000372292.3	-	8	1050	c.1010G>A	c.(1009-1011)tGg>tAg	p.W337*		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	337	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CCCTGGGGCCCAGTTGGAATA	0.547000													75	212					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080195	54080195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54080195G>A	ENST00000253144.9	+	7	1714	c.381G>A	c.(379-381)aaG>aaA	p.K127K	ZNF331_ENST00000512387.1_Silent_p.K127K|ZNF331_ENST00000511593.2_Silent_p.K127K|ZNF331_ENST00000511154.1_Silent_p.K127K|ZNF331_ENST00000449416.1_Silent_p.K127K|ZNF331_ENST00000513265.1_Intron|ZNF331_ENST00000513999.1_Silent_p.K127K|ZNF331_ENST00000411977.2_Silent_p.K127K	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GACATCATAAGGAGAATTCCT	0.423000			T	?	follicular thyroid adenoma								36	85					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12639525	12639525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12639525G>A	ENST00000425538.1	+	6	663	c.463G>A	c.(463-465)Gag>Aag	p.E155K	MYOCD_ENST00000395988.1_Missense_Mutation_p.E59K|MYOCD_ENST00000343344.4_Missense_Mutation_p.E155K	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	155	HDAC5-binding (By similarity).				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TGCCTTTGAAGAGGACAGCAG	0.547000													88	130					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075177	106075177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106075177G>A	ENST00000278071.2	-	3	1085	c.633C>T	c.(631-633)ttC>ttT	p.F211F	ITPRIP_ENST00000358187.2_Silent_p.F211F|ITPRIP_ENST00000337478.1_Silent_p.F211F	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	211						plasma membrane		p.F211F(1)		breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						TGAAGGGCACGAAAAGGTGGC	0.637000													34	62					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756582	15756582	+	Silent	SNP	C	C	T	rs148575704	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15756582C>T	ENST00000221307.7	+	3	300	c.252C>T	c.(250-252)ttC>ttT	p.F84F	CYP4F3_ENST00000586182.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000591058.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	84					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding	p.F84F(1)		endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CATGCACCTTCGGTGATATGT	0.557000													34	76					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838180	112838180	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:112838180C>A	ENST00000280155.2	+	1	1391	c.426C>A	c.(424-426)atC>atA	p.I142I		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	127					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	TGTGCGCCATCAGCCTGGACC	0.602000													11	37					1.61879e-10	1.62525e-10	1	1	0
CSF2RB	1439	broad.mit.edu	37	22	37334447	37334447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37334447C>T	ENST00000262825.5	+	14	2832	c.2615C>T	c.(2614-2616)cCc>cTc	p.P872L	CSF2RB_ENST00000406230.1_Missense_Mutation_p.P872L|CSF2RB_ENST00000403662.3_Missense_Mutation_p.P866L|CSF2RB_ENST00000536485.1_Missense_Mutation_p.P813L	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	866					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CAGGCTGTGCCCCAGGTGCCC	0.592000													43	162					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149129189	149129189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149129189G>A	ENST00000247930.4	-	6	2497	c.2174C>T	c.(2173-2175)cCc>cTc	p.P725L		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CTCGCACTCGGGGCACTTGAA	0.677000													25	108					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21153424	21153424	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21153424A>T	ENST00000269228.5	-	2	726	c.172T>A	c.(172-174)Tta>Ata	p.L58I	NPC1_ENST00000540608.1_Intron	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	58					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ACCTGCACTAAGTCATATCCA	0.423000													58	141					0	0	1	0	0
IL17A	3605	broad.mit.edu	37	6	52052496	52052496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52052496C>T	ENST00000340057.1	+	2	168	c.123C>T	c.(121-123)ttC>ttT	p.F41F		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	41					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity	p.F41F(1)		endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					ACAAGAACTTCCCCCGGACTG	0.498000													16	203					0	0	1	0	0
ENKUR	219670	broad.mit.edu	37	10	25279504	25279504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25279504C>T	ENST00000331161.4	-	4	701	c.482G>A	c.(481-483)cGa>cAa	p.R161Q	ENKUR_ENST00000376363.1_Missense_Mutation_p.R161Q	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	161						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						TTCCTCGTTTCGCTTACATAT	0.358000													12	59					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36124361	36124361	+	Missense_Mutation	SNP	G	G	A	rs139182630		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36124361G>A	ENST00000296603.4	-	7	1216	c.754C>T	c.(754-756)Cgt>Tgt	p.R252C		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	252						integral to membrane		p.R252C(1)		breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTCACTTTACGAACCTCCTAT	0.279000													15	43					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128840283	128840283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128840283G>A	ENST00000310343.9	-	22	4782	c.4783C>T	c.(4783-4785)Cgc>Tgc	p.R1595C	ARHGAP32_ENST00000392657.3_Missense_Mutation_p.R1246C|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.R1246C	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1595	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GGAACAGAGCGAATCATGGAA	0.542000													20	43					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120430	94120430	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:94120430G>A	ENST00000369303.4	-	3	805	c.621C>T	c.(619-621)tcC>tcT	p.S207S	EPHA7_ENST00000369297.1_Silent_p.S207S	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	207	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TCTCAATAATGGACCAGCACT	0.438000													5	55					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50534736	50534736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50534736G>A	ENST00000267845.3	-	12	2112	c.1710C>T	c.(1708-1710)ttC>ttT	p.F570F	HDC_ENST00000543581.1_Silent_p.F537F	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	570					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ACAAGTAACTGAACAGGAAGG	0.537000													53	152					0	0	1	0	0
MYBPH	4608	broad.mit.edu	37	1	203144855	203144855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203144855G>A	ENST00000255416.4	-	1	86	c.29C>T	c.(28-30)cCt>cTt	p.P10L		NM_004997.2	NP_004988.2	Q13203	MYBPH_HUMAN	myosin binding protein H	10					cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle			endometrium(5)|large_intestine(6)|lung(7)|skin(1)|urinary_tract(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		ACTGCAGGCAGGGCCCTCGGA	0.627000													39	86					0	0	1	0	0
LHFPL3	375612	broad.mit.edu	37	7	104377342	104377342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:104377342G>A	ENST00000535008.1	+	4	790	c.666G>A	c.(664-666)ctG>ctA	p.L222L	LHFPL3_ENST00000401970.2_Silent_p.L208L|LHFPL3_ENST00000543266.1_Silent_p.L222L|LHFPL3_ENST00000424859.1_Silent_p.L208L			Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	208						integral to membrane				kidney(1)|large_intestine(2)|lung(6)	9						CAGAGGAACTGAAGGCAGAAA	0.418000													6	12					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159778902	159778902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159778902G>A	ENST00000321935.6	+	5	578	c.492G>A	c.(490-492)caG>caA	p.Q164Q	FCRL6_ENST00000392235.3_Intron|FCRL6_ENST00000339348.5_Silent_p.Q157Q|FCRL6_ENST00000368106.3_Silent_p.Q157Q			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	157	Ig-like C2-type 2.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					ACACCTTGCAGGACAGGGGCC	0.617000													15	65					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233085	21233085	+	Missense_Mutation	SNP	G	G	A	rs141641980		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21233085G>A	ENST00000233242.1	-	26	6782	c.6655C>T	c.(6655-6657)Cgt>Tgt	p.R2219C		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2219					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAATTTACACGGATATGATAG	0.254000													12	49					0	0	1	0	0
AQP12B	653437	broad.mit.edu	37	2	241622226	241622226	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241622226A>T	ENST00000407834.3	-	1	91	c.29T>A	c.(28-30)tTc>tAc	p.F10Y		NM_001102467.1	NP_001095937.1	A6NM10	AQ12B_HUMAN	aquaporin 12B	10						integral to membrane	transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|lung(8)|ovary(1)	13		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GGCAAAGAAGAAGGAGAGGGA	0.667000													29	75					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112770107	112770107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:112770107G>A	ENST00000390666.3	-	1	621	c.430C>T	c.(430-432)Ctt>Ttt	p.L144F	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000416046.2_RNA|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	144	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TCCTTGTCAAGGAGAAGGTTG	0.547000													30	41					0	0	1	0	0
MAP3K11	4296	broad.mit.edu	37	11	65373509	65373509	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65373509G>A	ENST00000309100.3	-	7	2132	c.1647C>T	c.(1645-1647)ccC>ccT	p.P549P	MAP3K11_ENST00000532507.1_5'UTR|MAP3K11_ENST00000534432.1_5'UTR|MAP3K11_ENST00000530153.1_Silent_p.P292P	NM_002419.3	NP_002410.1	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase 11	549					activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(14)|skin(1)	24						CCAGACGTCGGGGGGACTGGC	0.607000													8	21					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	174096	174096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:174096C>T	ENST00000283426.6	+	16	3267	c.3217C>T	c.(3217-3219)Cgc>Tgc	p.R1073C		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	1073	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GATTTGGTTTCGCAGGCGGCG	0.562000													5	12					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22149821	22149821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:22149821G>A	ENST00000389398.5	+	22	2376	c.2280G>A	c.(2278-2280)ctG>ctA	p.L760L	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	760						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CCGTCCCCCTGGGGGCCAGAA	0.527000													4	34					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17235031	17235031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:17235031G>A	ENST00000261381.6	-	7	1650	c.1566C>T	c.(1564-1566)tcC>tcT	p.S522S		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	522					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GCAGGGTGTAGGAGTAGAACT	0.478000													38	316					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107113782	107113782	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107113782G>A	ENST00000392842.1	+	12	1597	c.1183G>A	c.(1183-1185)Gag>Aag	p.E395K	RP11-482D24.3_ENST00000552415.1_RNA|RFX4_ENST00000357881.4_Missense_Mutation_p.E404K|RFX4_ENST00000229387.5_Missense_Mutation_p.E301K|RP11-144F15.1_ENST00000551505.1_Intron	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	395	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GTCTCCCATCGAGTCCTACAT	0.527000													31	76					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203188883	203188883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203188883G>A	ENST00000367229.1	-	8	858	c.824C>T	c.(823-825)tCc>tTc	p.S275F	CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000535569.1_Missense_Mutation_p.S266F|CHIT1_ENST00000255427.3_Missense_Mutation_p.S256F	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	275					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						GTCTGATGAGGAGGCCAGTGT	0.602000													34	60					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878721	24878721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24878721G>A	ENST00000382554.3	+	4	2039	c.1721G>A	c.(1720-1722)cGa>cAa	p.R574Q		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	574					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCTACATCTCGAATGATGCTG	0.527000													8	23					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25415724	25415724	+	RNA	SNP	C	C	T	rs77022855	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25415724C>T	ENST00000549301.1	+	0	238				SNHG14_ENST00000553149.1_RNA																							CCCAATGGCCCTCGGCCAGTG	0.617000													9	26					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33648129	33648129	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33648129C>T	ENST00000374316.5	+	33	5308	c.4248C>T	c.(4246-4248)ttC>ttT	p.F1416F	ITPR3_ENST00000605930.1_Silent_p.F1416F			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1416					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						ATGTGAACTTCGTGAACCACT	0.602000													14	38					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100488880	100488880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100488880C>T	ENST00000302913.4	-	4	1771	c.1633G>A	c.(1633-1635)Gac>Aac	p.D545N	ACHE_ENST00000428317.1_Missense_Mutation_p.D545N|ACHE_ENST00000412389.1_Missense_Mutation_p.D545N|ACHE_ENST00000411582.1_Missense_Mutation_p.D545N|ACHE_ENST00000241069.5_Missense_Mutation_p.D545N|ACHE_ENST00000419336.2_Missense_Mutation_p.D457N	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	545					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GGCCGCAGGTCCAGACTAACG	0.687000													18	33					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81664975	81664975	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81664975G>A	ENST00000558726.1	-	2	328	c.193C>T	c.(193-195)Cgc>Tgc	p.R65C	TMC3_ENST00000359440.5_Missense_Mutation_p.R65C			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	65						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						GGTCTGCAGCGAATGTTTGCC	0.463000													35	135					0	0	1	0	0
IL26	55801	broad.mit.edu	37	12	68619245	68619245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:68619245C>T	ENST00000229134.4	-	2	271	c.207G>A	c.(205-207)aaG>aaA	p.K69K	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	69					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTTTTGTTTTCTTTTTTAATA	0.279000													9	36					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85715876	85715876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85715876G>A	ENST00000322366.6	-	21	3690	c.3283C>T	c.(3283-3285)Cct>Tct	p.P1095S	WDFY3_ENST00000295888.4_Missense_Mutation_p.P1095S			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1095						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GAGGGAGGAGGGAAGAATCTT	0.343000													16	41					0	0	1	0	0
HAS1	3036	broad.mit.edu	37	19	52220383	52220383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52220383C>T	ENST00000540069.2	-	3	823	c.763G>A	c.(763-765)Gag>Aag	p.E255K	HAS1_ENST00000594621.1_Missense_Mutation_p.E110K|HAS1_ENST00000601714.1_Missense_Mutation_p.E263K|HAS1_ENST00000222115.1_Missense_Mutation_p.E256K			Q92839	HAS1_HUMAN	hyaluronan synthase 1	256					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CGGGGGTCCTCGTCCAGTACC	0.622000													30	89					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31914886	31914886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31914886G>A	ENST00000456570.1	+	15	1962	c.1907G>A	c.(1906-1908)gGt>gAt	p.G636D	CFB_ENST00000425368.2_Missense_Mutation_p.G134D|CFB_ENST00000477310.1_Missense_Mutation_p.G485D|CFB_ENST00000556679.1_Missense_Mutation_p.G636D			P00751	CFAB_HUMAN	complement factor B	134	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TGCTATGACGGTTACACTCTC	0.557000													33	82					0	0	1	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280812	105280812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105280812G>A	ENST00000327674.4	-	1	573	c.238C>T	c.(238-240)Ctt>Ttt	p.L80F	SERPINA7_ENST00000372563.1_Missense_Mutation_p.L80F			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	80					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	CCAAAGGAAAGCATAACCAAA	0.498000													30	30					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40916996	40916996	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40916996C>T	ENST00000346991.5	+	11	5002	c.4612C>T	c.(4612-4614)Caa>Taa	p.Q1538*	CASC5_ENST00000399668.2_Nonsense_Mutation_p.Q1512*			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1538					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		GGAAAATATTCAAACAACTAA	0.383000													19	35					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995918	140995918	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140995918G>A	ENST00000285879.4	+	4	3014	c.2728G>A	c.(2728-2730)Gaa>Aaa	p.E910K	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	910	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TACACTGGATGAAAAGGTGGA	0.468000										HNSCC(15;0.026)			86	75					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16638370	16638370	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:16638370C>T	ENST00000443444.2	+	12	2925	c.2785C>T	c.(2785-2787)Caa>Taa	p.Q929*	CCDC144A_ENST00000456009.1_Nonsense_Mutation_p.Q649*|RP11-219A15.1_ENST00000448331.3_Nonsense_Mutation_p.Q929*|CCDC144A_ENST00000360524.8_Nonsense_Mutation_p.Q929*|CCDC144A_ENST00000399273.1_Nonsense_Mutation_p.Q929*			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	929																	TGACTGTGATCAAAGTCAGAC	0.408000													14	12					0	0	1	0	0
TMEM27	57393	broad.mit.edu	37	X	15657812	15657812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:15657812G>A	ENST00000380342.3	-	5	640	c.385C>T	c.(385-387)Cct>Tct	p.P129S		NM_020665.4	NP_065716.1	Q9HBJ8	TMM27_HUMAN	transmembrane protein 27	129					proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			endometrium(3)|lung(4)|ovary(1)	8	Hepatocellular(33;0.183)					AGTGTGGAAGGGATTTTTAAA	0.348000													58	52					0	0	1	0	0
NKAIN3	286183	broad.mit.edu	37	8	63659578	63659578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:63659578C>T	ENST00000523211.1	+	4	493	c.361C>T	c.(361-363)Ccc>Tcc	p.P121S	NKAIN3_ENST00000519049.1_3'UTR|NKAIN3_ENST00000328472.5_Missense_Mutation_p.P121S	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	121						integral to membrane|plasma membrane				kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				AGTGCTGCCTCCCTCAGCCCA	0.517000													13	23					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961398	1961398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1961398G>A	ENST00000217305.2	-	4	561	c.336C>T	c.(334-336)ctC>ctT	p.L112L	RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Silent_p.L112L|PDYN_ENST00000539905.1_Silent_p.L112L	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	112					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGATACTTGGGAGAAACTTGC	0.552000													38	72					0	0	1	0	0
TAS2R42	353164	broad.mit.edu	37	12	11338854	11338854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11338854C>T	ENST00000334266.1	-	1	689	c.690G>A	c.(688-690)agG>agA	p.R230R		NM_181429.1	NP_852094.1	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	230					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(2)|lung(4)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			TCATGGCCCTCCTATGGGCCT	0.408000													23	98					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287712	16287712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:16287712C>T	ENST00000343518.6	-	1	225	c.174G>A	c.(172-174)agG>agA	p.R58R		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	58										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CCATCTTGCTCCTGAGTGTCT	0.607000													65	368					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57432321	57432321	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57432321G>A	ENST00000442789.2	-	18	1922	c.1635C>T	c.(1633-1635)tcC>tcT	p.S545S	MYO1A_ENST00000544473.1_Silent_p.S383S|MYO1A_ENST00000476795.1_5'UTR|MYO1A_ENST00000300119.3_Silent_p.S545S	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	545	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						CAGGAAACAAGGACCGAAGGA	0.532000													26	100					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42754805	42754805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42754805C>T	ENST00000310232.6	-	14	1805	c.1722G>A	c.(1720-1722)gtG>gtA	p.V574V		NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	574										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						TGCTCTCCTCCACCCTGGTGA	0.602000													11	116					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122769437	122769437	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122769437C>T	ENST00000194130.2	-	9	1070	c.1031_splice	c.e9+1	p.R344_splice	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	344						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	tttgtCTTACCTTATTGGCCC	0.413000													13	61					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111779604	111779604	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111779604G>A	ENST00000261726.6	+	21	3560	c.3406G>A	c.(3406-3408)Ggc>Agc	p.G1136S		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1136						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						ACGTCGCTATGGCCTCATCAG	0.642000													46	84					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1719914	1719914	+	Silent	SNP	C	C	T	rs150074892		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1719914C>T	ENST00000313871.3	+	5	1711	c.1515C>T	c.(1513-1515)gcC>gcT	p.A505A		NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	505					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						ACCCAGAGGCCGACGGCGCTC	0.716000													4	6					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248790279	248790279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248790279G>A	ENST00000330803.2	-	1	212	c.151C>T	c.(151-153)Cgc>Tgc	p.R51C		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGTGGAGGCGAGAGTCCACC	0.498000													25	78					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5485338	5485338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:5485338C>T	ENST00000345221.3	-	3	1047	c.493G>A	c.(493-495)Gac>Aac	p.D165N	NLRP1_ENST00000262467.5_Missense_Mutation_p.D165N|NLRP1_ENST00000577119.1_Missense_Mutation_p.D165N|NLRP1_ENST00000572272.1_Missense_Mutation_p.D165N|NLRP1_ENST00000269280.4_Missense_Mutation_p.D165N|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000354411.3_Missense_Mutation_p.D165N	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	165					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GACTCATGGTCTGGGGAGCTT	0.522000													8	18					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6055780	6055780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6055780G>A	ENST00000409021.3	-	13	2252	c.1803C>T	c.(1801-1803)ctC>ctT	p.L601L	JAKMIP1_ENST00000410077.2_Silent_p.L436L|JAKMIP1_ENST00000409831.1_Silent_p.L601L|JAKMIP1_ENST00000409371.3_Silent_p.L416L|JAKMIP1_ENST00000282924.5_Silent_p.L601L	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	601	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding	p.L601L(2)		NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTCTTACTTCGAGTTCTAGCA	0.403000													65	162					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10579331	10579331	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:10579331T>A	ENST00000334534.5	+	5	427	c.247T>A	c.(247-249)Ttt>Att	p.F83I		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		AGGTTATGGCTTTCAAATCAC	0.453000													8	58					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51957554	51957554	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51957554C>T	ENST00000321424.3	-	6	1230	c.1164G>A	c.(1162-1164)agG>agA	p.R388R	SIGLEC8_ENST00000340550.5_Silent_p.R295R|SIGLEC8_ENST00000430817.1_Silent_p.R279R	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	388			R -> G (in dbSNP:rs3829659).		cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CCGATTTCTTCCTGCAGGACC	0.587000													32	83					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220792011	220792011	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:220792011C>T	ENST00000402574.1	+	9	1420	c.418C>T	c.(418-420)Cgt>Tgt	p.R140C	MARK1_ENST00000366918.4_Missense_Mutation_p.R253C|MARK1_ENST00000366917.4_Missense_Mutation_p.R275C	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	275	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		AGGGAAGTACCGTATTCCCTT	0.353000													10	109					0	0	1	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113661321	113661321	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113661321C>T	ENST00000393544.2	+	0	1369																											TGAAGGAGTTCGTCTTTGATG	0.493000													63	69					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149840229	149840229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:149840229G>A	ENST00000435030.1	+	15	2033	c.1665G>A	c.(1663-1665)ttG>ttA	p.L555L	KIF5C_ENST00000397413.1_Silent_p.L323L|KIF5C_ENST00000414838.2_Silent_p.L460L|KIF5C_ENST00000464066.1_3'UTR			O60282	KIF5C_HUMAN	kinesin family member 5C	555					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		ATTTGCTGTTGAAAGATCTGG	0.453000													15	35					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63883877	63883877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63883877G>A	ENST00000246841.3	+	2	1181	c.138G>A	c.(136-138)acG>acA	p.T46T	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	18	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity	p.T46T(1)		breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CCTTCCTGACGGAGGTCATCG	0.637000													11	35					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943142	72943142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72943142G>A	ENST00000328801.4	+	6	1192	c.1192G>A	c.(1192-1194)Ggg>Agg	p.G398R		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	398						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					AGCCATACACGGGCTGGAGGA	0.607000													18	41					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228479639	228479639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228479639G>A	ENST00000570156.2	+	44	11741	c.11667G>A	c.(11665-11667)gaG>gaA	p.E3889E	OBSCN_ENST00000366707.4_Silent_p.E579E|OBSCN_ENST00000422127.1_Silent_p.E3460E|OBSCN_ENST00000284548.11_Silent_p.E3460E|OBSCN_ENST00000366709.4_Silent_p.E579E|OBSCN_ENST00000359599.6_Silent_p.E2307E	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2926					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGAATGAAGAGGCCGTGGAAG	0.587000													14	32					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14650966	14650966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14650966C>T	ENST00000544627.1	+	15	4116	c.3796C>T	c.(3796-3798)Cct>Tct	p.P1266S	ATF7IP_ENST00000536444.1_Missense_Mutation_p.P1257S|ATF7IP_ENST00000540793.1_Missense_Mutation_p.P1258S|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P1258S			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	1258	Interaction with MBD1.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TTTCTGTGATCCTCAGTCAAC	0.408000													52	288					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68947229	68947229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:68947229G>A	ENST00000456315.2	-	9	1943	c.1829C>T	c.(1828-1830)cCc>cTc	p.P610L	RP4-694A7.2_ENST00000425820.1_RNA|DEPDC1_ENST00000370966.5_Missense_Mutation_p.P326L	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	610	Interaction with ZNF224.				intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		ATTTGGTGGGGGAAGTAACAA	0.413000													14	21					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99013074	99013074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99013074C>T	ENST00000393504.1	+	8	1858	c.1441C>T	c.(1441-1443)Cgc>Tgc	p.R481C	CNGA3_ENST00000436404.2_Missense_Mutation_p.R463C|CNGA3_ENST00000272602.2_Missense_Mutation_p.R481C|CNGA3_ENST00000409937.1_Missense_Mutation_p.R485C	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	481					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						GAAGAAGGTTCGCATCTTCCA	0.567000													13	22					0	0	1	0	0
REM2	161253	broad.mit.edu	37	14	23353973	23353973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23353973G>A	ENST00000267396.4	+	2	317	c.194G>A	c.(193-195)cGa>cAa	p.R65Q	REM2_ENST00000536884.1_Missense_Mutation_p.R65Q	NM_173527.2	NP_775798.2	Q8IYK8	REM2_HUMAN	RAS (RAD and GEM)-like GTP binding 2	65					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			breast(1)|central_nervous_system(1)|large_intestine(2)|ovary(1)	5	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		GCCCCCAGACGAAGAGGCAGT	0.577000													24	42					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41439581	41439581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:41439581G>A	ENST00000301831.4	-	35	4129	c.3667C>T	c.(3667-3669)Ctc>Ttc	p.L1223F		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	1223							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		ATTCTTCTGAGAATCCTTAAC	0.478000													35	100					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64535205	64535205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64535205G>A	ENST00000377390.3	-	10	1517	c.1180C>T	c.(1180-1182)Ccc>Tcc	p.P394S	SF1_ENST00000377387.1_Missense_Mutation_p.P519S|SF1_ENST00000433274.2_Missense_Mutation_p.P368S|SF1_ENST00000422298.2_Missense_Mutation_p.P279S|SF1_ENST00000334944.5_Missense_Mutation_p.P394S|SF1_ENST00000227503.9_Missense_Mutation_p.P394S|SF1_ENST00000377394.3_Missense_Mutation_p.P394S	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	394	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						AAGCTGTGGGGGCCACCTCCG	0.647000											OREG0004010|OREG0021062	type=REGULATORY REGION|Gene=LOC476031|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	39					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10465203	10465203	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10465203G>A	ENST00000525621.1	-	19	3181	c.2700C>T	c.(2698-2700)atC>atT	p.I900I	TYK2_ENST00000264818.6_Silent_p.I900I|TYK2_ENST00000524462.1_Silent_p.I715I	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	900	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCAGATCTCGGATCTTTTTCA	0.557000													34	73					0	0	1	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047149	46047149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46047149G>A	ENST00000397911.3	+	1	110	c.61G>A	c.(61-63)Gac>Aac	p.D21N	KRTAP10-9_ENST00000484861.1_3'UTR|TSPEAR_ENST00000323084.4_Intron	NM_198690.2	NP_941963.2	P60411	KR109_HUMAN	keratin associated protein 10-9	21						keratin filament				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9						GCAGGTGGACGACTGCCCAGA	0.687000													39	75					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27458232	27458232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27458232C>T	ENST00000264705.4	+	24	4068	c.3906C>T	c.(3904-3906)gcC>gcT	p.A1302A	CAD_ENST00000403525.1_Silent_p.A1239A	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1302	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	ACCTCAAGGCCATGCTAAGCA	0.582000													44	88					0	0	1	0	0
SLC5A5	6528	broad.mit.edu	37	19	18004539	18004539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18004539C>T	ENST00000222248.3	+	15	2132	c.1785C>T	c.(1783-1785)ccC>ccT	p.P595P		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	595					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						AAGAACTCCCCACTGGAAACA	0.582000													10	32					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94983447	94983447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94983447C>T	ENST00000357742.4	+	17	2128	c.2128C>T	c.(2128-2130)Ccc>Tcc	p.P710S	MCTP2_ENST00000451018.3_Intron	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	710					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			ATATATGATCCCCTTGGCATT	0.413000													47	355					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31593296	31593296	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31593296G>A	ENST00000379416.3	-	18	1953	c.1905C>T	c.(1903-1905)ttC>ttT	p.F635F		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	635					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CAGCGGAAATGAAACAAACAA	0.438000													10	50					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637430	248637430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248637430C>T	ENST00000359594.2	+	1	804	c.779C>T	c.(778-780)tCc>tTc	p.S260F		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCGGTGCTTCCTTCTACACC	0.557000													103	363					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32498033	32498033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32498033G>A	ENST00000266088.4	+	13	1724	c.1474G>A	c.(1474-1476)Gga>Aga	p.G492R	SLC5A1_ENST00000543737.1_Missense_Mutation_p.G365R	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	492					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						ACTGATCCTAGGACTTCTGAT	0.483000													26	58					0	0	1	0	0
TTLL13P	440307	broad.mit.edu	37	15	90794047	90794047	+	Missense_Mutation	SNP	C	C	T	rs144811975		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90794047C>T	ENST00000561573.1	+	2	449	c.185C>T	c.(184-186)cCg>cTg	p.P62L	TTLL13_ENST00000339615.5_Missense_Mutation_p.P62L|TTLL13_ENST00000438251.1_Missense_Mutation_p.P62L																							ACAAAAATTCCGAAGAAAGTC	0.478000													103	139					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24823824	24823824	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:24823824C>T	ENST00000424834.2	+	5	2336	c.1863C>T	c.(1861-1863)gaC>gaT	p.D621D	SPATA13_ENST00000382095.4_5'UTR|SPATA13_ENST00000382108.3_Silent_p.D621D			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	0	C-terminal tail.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		TGGACGAGGACCCCCAGGCAA	0.607000													37	136					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29230478	29230478	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29230478C>T	ENST00000441381.1	+	0	79																											ACTCCTTATTCCTTAGTGGGA	0.413000													18	38					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983508	123983508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:123983508G>A	ENST00000306315.5	-	4	3004	c.2569C>T	c.(2569-2571)Cat>Tat	p.H857Y	ZNF608_ENST00000504926.1_Missense_Mutation_p.H430Y	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	857						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TTGTTGAGATGATCCTTTAAA	0.498000													22	169					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78778131	78778131	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78778131T>C	ENST00000258886.8	+	13	1807	c.1658T>C	c.(1657-1659)gTt>gCt	p.V553A		NM_004136.2	NP_004127.1	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	553							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AGTGGGATGGTTACACATTAC	0.403000													149	151					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58330267	58330267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58330267G>A	ENST00000371015.1	+	4	856	c.389G>A	c.(388-390)gGa>gAa	p.G130E	PHACTR3_ENST00000395639.4_Missense_Mutation_p.G89E|PHACTR3_ENST00000361300.4_Missense_Mutation_p.G89E|PHACTR3_ENST00000359926.3_Missense_Mutation_p.G127E|PHACTR3_ENST00000541461.1_Missense_Mutation_p.G89E|PHACTR3_ENST00000395636.2_Missense_Mutation_p.G89E|PHACTR3_ENST00000355648.4_Missense_Mutation_p.G89E	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	130						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			AACCCCGATGGAGGACCCCGA	0.577000													16	49					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50528136	50528136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50528136G>A	ENST00000267842.5	+	10	1938	c.1706G>A	c.(1705-1707)gGa>gAa	p.G569E	SLC27A2_ENST00000544960.1_Missense_Mutation_p.G334E|SLC27A2_ENST00000380902.4_Missense_Mutation_p.G516E	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	569					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GAGATCACTGGAACTTTTAAA	0.428000													17	149					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33632886	33632886	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33632886C>T	ENST00000374316.5	+	14	2365	c.1305C>T	c.(1303-1305)ccC>ccT	p.P435P	ITPR3_ENST00000605930.1_Silent_p.P435P			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	435					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						TGTCAGTGCCCGTGTCTGAGA	0.612000													25	123					0	0	1	0	0
STX4	6810	broad.mit.edu	37	16	31045633	31045633	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31045633C>T	ENST00000394998.1	+	4	556	c.213C>T	c.(211-213)ccC>ccT	p.P71P	STX4_ENST00000493902.1_3'UTR|STX4_ENST00000313843.3_Silent_p.P73P	NM_001272096.1	NP_001259025.1	Q12846	STX4_HUMAN	syntaxin 4	73					intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity			NS(2)|breast(1)|large_intestine(3)|lung(3)	9						TGGCCACGCCCCTTCCCGAGG	0.602000													41	74					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61562572	61562572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61562572C>T	ENST00000457692.1	+	4	576	c.243C>T	c.(241-243)ttC>ttT	p.F81F	SERPINB2_ENST00000482254.1_3'UTR|SERPINB2_ENST00000299502.4_Silent_p.F81F	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	81					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	GCTGTGGGTTCATGCAGCAGA	0.433000													70	135					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36869813	36869813	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36869813G>A	ENST00000301807.6	-	23	8978	c.7081C>T	c.(7081-7083)Cgg>Tgg	p.R2361W	TRANK1_ENST00000429976.2_Missense_Mutation_p.R2911W|TRANK1_ENST00000428977.2_Missense_Mutation_p.R2361W	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2911					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CTTCTAGGCCGAAGCTCACCA	0.443000													10	20					0	0	1	0	0
CLCN7	1186	broad.mit.edu	37	16	1497080	1497080	+	Missense_Mutation	SNP	G	G	A	rs140032494		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1497080G>A	ENST00000382745.4	-	24	2863	c.2258C>T	c.(2257-2259)tCg>tTg	p.S753L	CLCN7_ENST00000448525.1_Missense_Mutation_p.S729L|CLCN7_ENST00000262318.8_Silent_p.V729V	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	753	CBS 2.					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				CCGTGGGAGCGACGCCTCCTG	0.716000													5	10					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60063501	60063501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:60063501G>A	ENST00000267484.5	-	9	2628	c.2293C>T	c.(2293-2295)Cag>Tag	p.Q765*	RTN1_ENST00000342503.4_Nonsense_Mutation_p.Q197*|RTN1_ENST00000395090.1_Nonsense_Mutation_p.Q182*|RTN1_ENST00000557422.1_5'UTR	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	765	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		ATTTTAGCCTGAATCCTAAAA	0.398000													32	83					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20649578	20649578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20649578G>A	ENST00000525748.1	+	9	1721	c.1448G>A	c.(1447-1449)gGa>gAa	p.G483E		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	483					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	GCTGCATGGGGAGGCCTGATC	0.473000													19	93					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57918040	57918040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57918040C>T	ENST00000574161.1	+	5	594	c.475C>T	c.(475-477)Cgt>Tgt	p.R159C	GCOM1_ENST00000380561.2_Missense_Mutation_p.R128C|GCOM1_ENST00000572390.1_Missense_Mutation_p.R159C|GCOM1_ENST00000380560.2_Intron|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Missense_Mutation_p.R159C|GCOM1_ENST00000587652.1_Missense_Mutation_p.R159C|GCOM1_ENST00000396180.1_Missense_Mutation_p.R128C|MYZAP_ENST00000267853.5_Missense_Mutation_p.R159C|GCOM1_ENST00000380568.3_Missense_Mutation_p.R159C|MYZAP_ENST00000380565.4_Missense_Mutation_p.R159C	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		159					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						TGCCCTGGATCGTTTTAATGC	0.483000													23	43					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35390870	35390870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35390870G>A	ENST00000426836.1	-	6	956	c.584C>T	c.(583-585)tCa>tTa	p.S195L	DSN1_ENST00000373745.3_Missense_Mutation_p.S195L|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000373750.4_Missense_Mutation_p.S195L|DSN1_ENST00000448110.1_Missense_Mutation_p.S179L|DSN1_ENST00000373734.4_Missense_Mutation_p.S88L|DSN1_ENST00000373740.3_Missense_Mutation_p.S123L	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	195					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TTACCCATTTGAATCTTCAAA	0.423000													13	41					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52790732	52790732	+	Missense_Mutation	SNP	C	C	T	rs142616498	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52790732C>T	ENST00000257974.2	-	6	1080	c.1003G>A	c.(1003-1005)Gag>Aag	p.E335K	RP3-416H24.4_ENST00000547174.1_RNA	NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	335	Coil 2.|Rod.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		TCCAGGATCTCGTTCTTACGG	0.557000													13	37					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661734	77661734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77661734C>T	ENST00000296043.6	+	5	3361	c.2408C>T	c.(2407-2409)tCt>tTt	p.S803F		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	803					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GTGGGCGGCTCTGGTTTTGGC	0.552000													21	65					0	0	1	0	0
ZNF280A	129025	broad.mit.edu	37	22	22868820	22868820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22868820G>A	ENST00000302097.3	-	2	1387	c.1135C>T	c.(1135-1137)Ctc>Ttc	p.L379F		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TGTTGTAAGAGGACCTGATCT	0.473000													9	144					0	0	1	0	0
CSNK1E	1454	broad.mit.edu	37	22	38690525	38690525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38690525G>A	ENST00000396832.1	-	8	1161	c.901C>T	c.(901-903)Ccc>Tcc	p.P301S	CSNK1E_ENST00000359867.3_Missense_Mutation_p.P301S|CSNK1E_ENST00000403904.1_Missense_Mutation_p.P301S|CSNK1E_ENST00000400206.2_Missense_Mutation_p.P301S	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	301					DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					ACATCCTCGGGATTCCGGGCT	0.692000													5	8					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97464925	97464925	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97464925C>T	ENST00000377075.2	+	4	1911	c.1813C>T	c.(1813-1815)Cga>Tga	p.R605*	CNNM4_ENST00000540067.1_Nonsense_Mutation_p.R92*|CNNM4_ENST00000496186.1_3'UTR	NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	605					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						CCTGTACACCCGAAATAAGCC	0.577000													21	79					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390532	8390532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8390532C>T	ENST00000471889.1	+	5	1364	c.979C>T	c.(979-981)Ccg>Tcg	p.P327S	SLC45A1_ENST00000377479.2_Missense_Mutation_p.P361S|SLC45A1_ENST00000481265.1_3'UTR|SLC45A1_ENST00000289877.8_Missense_Mutation_p.P327S			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	327					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CGACAGCCTCCCGTCGCACAC	0.711000													10	42					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92702991	92702991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92702991C>T	ENST00000257068.2	+	1	106	c.100C>T	c.(100-102)Cct>Tct	p.P34S		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	34					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CTCCAGGACCCCTCGACCTCC	0.716000													4	7					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915242	119915242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:119915242G>A	ENST00000331113.4	+	1	1521	c.556G>A	c.(556-558)Gtg>Atg	p.V186M		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	186					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GATGGCCCTGGTGTTCTACTA	0.577000													12	55					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96698514	96698514	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96698514G>A	ENST00000260682.6	+	1	87	c.75G>A	c.(73-75)ggG>ggA	p.G25G	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	25					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	AGAGCTCTGGGAGAGGAAAAC	0.453000													12	184					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385829	33385829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33385829G>A	ENST00000541274.1	-	5	615	c.166C>T	c.(166-168)Cgc>Tgc	p.R56C	AQP7_ENST00000377425.4_Silent_p.F130F|AQP7_ENST00000537089.1_Silent_p.F95F|AQP7_ENST00000539936.1_Silent_p.F187F			O14520	AQP7_HUMAN	aquaporin 7	294					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCGTGATGGCGAAGAGACACA	0.627000													9	68					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3723942	3723942	+	Missense_Mutation	SNP	G	G	C	rs146515319	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3723942G>C	ENST00000324932.7	-	23	3683	c.3263C>G	c.(3262-3264)cCg>cGg	p.P1088R	NUP98_ENST00000359171.4_Missense_Mutation_p.P1088R|NUP98_ENST00000355260.3_Missense_Mutation_p.P1088R	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1105					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TGTTTTCAACGGAACCTCAGG	0.512000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								14	41					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162683579	162683579	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:162683579G>A	ENST00000366898.1	-	3	492	c.390C>T	c.(388-390)gaC>gaT	p.D130D	PARK2_ENST00000366894.1_Intron|PARK2_ENST00000338468.3_5'UTR|PARK2_ENST00000366897.1_Silent_p.D130D|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000366892.1_Silent_p.D130D	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	130					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CTGGTGGTGAGTCCTTCCTGC	0.532000													27	37					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872882	55872882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55872882C>T	ENST00000313503.1	+	1	364	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R122C(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					GGCCCATGATCGCTATGCAGC	0.458000										HNSCC(53;0.14)			67	256					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30887889	30887889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30887889C>T	ENST00000392772.2	-	10	958	c.681G>A	c.(679-681)acG>acA	p.T227T	RP4-539M6.14_ENST00000442126.1_RNA|SEC14L4_ENST00000381982.3_Silent_p.T281T|SEC14L4_ENST00000255858.7_Silent_p.T281T|SEC14L4_ENST00000540456.1_Silent_p.T266T			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	281	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	CCACGGACCTCGTGTGCTCAT	0.622000													17	36					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742538	23742538	+	RNA	SNP	C	C	T	rs743353	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23742538C>T	ENST00000255890.4	-	0	671																											GGCCCACCCTCGGAGCACAGG	0.627000													4	18					0	0	1	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38413338	38413338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:38413338G>A	ENST00000377694.1	-	3	605	c.583C>T	c.(583-585)Cct>Tct	p.P195S		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	195	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		GTGCCCTCAGGGGACTTCGTG	0.577000													12	56					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115950740	115950740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:115950740G>A	ENST00000238256.3	-	13	1322	c.1205C>T	c.(1204-1206)cCt>cTt	p.P402L		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	402					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						AGTCACCACAGGCTGCCCACC	0.567000													8	77					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167293777	167293777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167293777C>T	ENST00000308378.3	-	4	720	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	WDR49_ENST00000453925.2_Missense_Mutation_p.E192K|WDR49_ENST00000479765.1_Missense_Mutation_p.E480K	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	139										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TTGCTGGCTTCACTTTTCATT	0.408000													69	158					0	0	1	0	0
PTGIR	5739	broad.mit.edu	37	19	47124807	47124807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47124807C>T	ENST00000291294.2	-	3	1024	c.891G>A	c.(889-891)aaG>aaA	p.K297K	PTGIR_ENST00000597185.1_Silent_p.K26K|PTGIR_ENST00000598865.1_Silent_p.K85K|PTGIR_ENST00000594275.1_Silent_p.K54K	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	297					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GGAAGACAGCCTTGCGGAAAA	0.632000													7	81					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810843	31810843	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:31810843G>A	ENST00000446923.2	+	7	2923	c.2532G>A	c.(2530-2532)gtG>gtA	p.V844V	ZEB1_ENST00000560721.2_Silent_p.V840V|ZEB1_ENST00000361642.5_Silent_p.V861V|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000542815.3_Silent_p.V793V|ZEB1_ENST00000320985.10_Silent_p.V860V	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	860					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CCTTGAAAGTGATCCAGCCAA	0.418000													23	53					0	0	1	0	0
HORMAD1	84072	broad.mit.edu	37	1	150672595	150672595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150672595C>T	ENST00000368993.2	-	14	1202	c.1097G>A	c.(1096-1098)gGg>gAg	p.G366E	HORMAD1_ENST00000368995.4_Missense_Mutation_p.G286E|HORMAD1_ENST00000361824.2_Missense_Mutation_p.G366E|HORMAD1_ENST00000322343.7_Missense_Mutation_p.G359E			Q86X24	HORM1_HUMAN	HORMA domain containing 1	366					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TACTATTCTCCCAGATTCATG	0.289000													8	39					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207140439	207140439	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207140439C>T	ENST00000324852.4	-	3	601	c.127G>A	c.(127-129)Gga>Aga	p.G43R	FCAMR_ENST00000450945.2_Missense_Mutation_p.G43R|FCAMR_ENST00000400962.3_Missense_Mutation_p.G43R	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	342						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						ATTTTCCATCCCGCCCTCCTG	0.527000													5	51					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135206752	135206752	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135206752G>T	ENST00000372169.2	-	8	1104	c.922C>A	c.(922-924)Ctt>Att	p.L308I	SETX_ENST00000393220.1_Missense_Mutation_p.L308I|SETX_ENST00000224140.5_Missense_Mutation_p.L308I			Q7Z333	SETX_HUMAN	senataxin	308					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GGATCCATAAGTTGACCCCAG	0.433000													16	62					4.14922e-12	4.16807e-12	1	1	0
C8orf34	116328	broad.mit.edu	37	8	69358714	69358714	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:69358714C>T	ENST00000523686.1	+	3	417	c.368C>T	c.(367-369)tCa>tTa	p.S123L	C8orf34_ENST00000539993.1_Intron|C8orf34_ENST00000518698.1_Intron|C8orf34_ENST00000337103.4_Intron|C8orf34_ENST00000348340.2_Intron|C8orf34_ENST00000349492.3_Intron			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	450					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			GTCTCTTATTCAAATGCTATT	0.328000													14	40					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114503831	114503831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114503831C>T	ENST00000394779.3	-	7	1034	c.790G>A	c.(790-792)Gaa>Aaa	p.E264K	C9orf84_ENST00000318737.4_Missense_Mutation_p.E303K|C9orf84_ENST00000374287.3_Missense_Mutation_p.E303K|C9orf84_ENST00000374283.5_Missense_Mutation_p.E367K|C9orf84_ENST00000394777.4_Missense_Mutation_p.E264K	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	303										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTAGCTGATTCTTCAGCAGTA	0.254000													21	55					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23862712	23862712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23862712C>T	ENST00000405093.3	-	23	3014	c.2944G>A	c.(2944-2946)Gag>Aag	p.E982K	MYH6_ENST00000356287.3_Missense_Mutation_p.E982K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	982					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCCATCTCCTCTGTTAGGTTC	0.532000													93	205					0	0	1	0	0
CLU	1191	broad.mit.edu	37	8	27457323	27457323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27457323C>T	ENST00000316403.10	-	7	1543	c.1138G>A	c.(1138-1140)Gac>Aac	p.D380N	CLU_ENST00000523500.1_Missense_Mutation_p.D380N|CLU_ENST00000546343.1_Missense_Mutation_p.D391N|CLU_ENST00000560366.1_Missense_Mutation_p.D432N|CLU_ENST00000405140.3_Missense_Mutation_p.D380N			P10909	CLUS_HUMAN	clusterin	380					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TAGTACTGGTCTTCGCCTTGC	0.602000													3	19					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115375563	115375563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115375563C>T	ENST00000369358.4	-	27	3254	c.3010G>A	c.(3010-3012)Gaa>Aaa	p.E1004K	NRAP_ENST00000360478.3_Missense_Mutation_p.E961K|NRAP_ENST00000359988.3_Missense_Mutation_p.E996K|NRAP_ENST00000369360.3_Missense_Mutation_p.E969K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	996						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TCTCCTTGTTCCCTGTATAAT	0.493000													8	18					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41759219	41759219	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:41759219C>T	ENST00000301831.4	-	23	2918		c.e23+1			NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4								ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTCCAATTTACCCAGGATTCG	0.453000													19	68					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411529	126411529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126411529C>T	ENST00000394329.3	+	17	13565	c.13552C>T	c.(13552-13554)Ctc>Ttc	p.L4518F	FAT4_ENST00000335110.5_Missense_Mutation_p.L2759F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4518					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CGTCTTGGCCCTCCTGGTCCT	0.557000													21	45					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136661589	136661589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136661589G>A	ENST00000371851.1	-	10	1304	c.979C>T	c.(979-981)Ccc>Tcc	p.P327S	VAV2_ENST00000406606.3_Missense_Mutation_p.P327S|VAV2_ENST00000371850.3_Missense_Mutation_p.P332S			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	332	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CTCTGCATGGGGACCACCAGC	0.612000													7	29					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44555716	44555716	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44555716C>T	ENST00000289547.4	-	18	3736	c.3681G>A	c.(3679-3681)agG>agA	p.R1227R	NPC1L1_ENST00000381160.3_Silent_p.R1200R|NPC1L1_ENST00000546276.1_Silent_p.R1154R	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1227					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	CCTCTTTGGCCCTCTCCAGCC	0.627000													6	11					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49006253	49006253	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49006253C>T	ENST00000600059.1	-	6	785	c.557_splice	c.e6-1	p.R186_splice	LMTK3_ENST00000270238.3_Splice_Site_p.R215_splice					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GCTGCAGGCTCCTGTGGAGTG	0.587000													4	28					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	57003538	57003538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57003538G>A	ENST00000200676.3	+	4	514	c.384G>A	c.(382-384)caG>caA	p.Q128Q	CETP_ENST00000566128.1_Silent_p.Q63Q|CETP_ENST00000379780.2_Silent_p.Q128Q|CETP_ENST00000569082.1_3'UTR	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	128					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						GTATTGATCAGTCCATTGACT	0.572000													10	78					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31040194	31040194	+	Missense_Mutation	SNP	C	C	T	rs142812385		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:31040194C>T	ENST00000355537.3	+	4	3815	c.3668C>T	c.(3667-3669)tCa>tTa	p.S1223L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGACTGGTCTCACCTTTATCC	0.662000													26	42					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37603235	37603235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37603235C>T	ENST00000399151.3	+	14	2238	c.2153C>T	c.(2152-2154)tCg>tTg	p.S718L		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	718					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CCATCGTCTTCGCCCAGCAGC	0.552000													20	44					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75508211	75508211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75508211C>T	ENST00000228027.7	+	6	903	c.643C>T	c.(643-645)Cct>Tct	p.P215S	DGAT2_ENST00000376262.3_Missense_Mutation_p.P172S	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	215					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					AGGTATCTGCCCTGTCAGCCG	0.542000													47	101					0	0	1	0	0
APCS	325	broad.mit.edu	37	1	159558247	159558247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159558247G>A	ENST00000255040.2	+	2	518	c.421G>A	c.(421-423)Ggt>Agt	p.G141S		NM_001639.3	NP_001630.1	P02743	SAMP_HUMAN	amyloid P component, serum	141	Pentaxin.		G -> S (in a breast cancer sample; somatic mutation).		acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding	p.G141S(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_hematologic(112;0.0429)					TCTGCGACAGGGTTACTTTGT	0.517000													10	50					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278458	50278458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:50278458C>T	ENST00000442544.2	+	2	742	c.126C>T	c.(124-126)ttC>ttT	p.F42F		NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	42	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CACTGCGCTTCCTCTCAGAAC	0.483000													15	44					0	0	1	0	0
AARD	441376	broad.mit.edu	37	8	117950651	117950651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:117950651G>A	ENST00000378279.3	+	1	214	c.169G>A	c.(169-171)Gag>Aag	p.E57K		NM_001025357.2	NP_001020528.1	Q4LEZ3	AARD_HUMAN	alanine and arginine rich domain containing protein	57																	CCCGCTGCTGGAGGACCTCAG	0.741000													7	20					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27169628	27169628	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27169628G>A	ENST00000380036.4	+	4	1070		c.e4+1		TEK_ENST00000519097.1_Splice_Site|TEK_ENST00000406359.4_Splice_Site	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial						angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ATAGTCCGGAGTAAGTGATGG	0.478000													28	59					0	0	1	0	0
TWSG1	57045	broad.mit.edu	37	18	9396289	9396289	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:9396289C>T	ENST00000262120.5	+	4	426	c.235C>T	c.(235-237)Cct>Tct	p.P79S	TWSG1_ENST00000581641.1_Missense_Mutation_p.P79S	NM_020648.5	NP_065699.1	Q9GZX9	TWSG1_HUMAN	twisted gastrulation BMP signaling modulator 1	79										breast(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|pancreas(2)	10						TATGTGTAATCCTCGAAATTA	0.418000													16	53					0	0	1	0	0
TRAV8-3	28683	broad.mit.edu	37	14	22321054	22321054	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22321054C>T	ENST00000390435.1	+	0	212																											AAGTACTTTTCAGGAGACACT	0.478000													9	27					0	0	1	0	0
CD19	930	broad.mit.edu	37	16	28944296	28944296	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28944296C>T	ENST00000538922.1	+	3	482	c.420C>T	c.(418-420)tcC>tcT	p.S140S	CD19_ENST00000567541.1_Silent_p.S140S|CD19_ENST00000324662.3_Silent_p.S140S	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	140					cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						AGAACAGGTCCTCAGAGGGCC	0.617000													3	14					0	0	1	0	0
RFPL1	5988	broad.mit.edu	37	22	29837733	29837733	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29837733G>A	ENST00000354373.2	+	2	785	c.576G>A	c.(574-576)tgG>tgA	p.W192*	RFPL1S_ENST00000539579.1_RNA|RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	192	B30.2/SPRY.						zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						GCACAGAATGGGACCTGGGAG	0.567000													44	129					0	0	1	0	0
KRTAP10-7	386675	broad.mit.edu	37	21	46021459	46021459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46021459C>T	ENST00000380102.2	+	1	963	c.938C>T	c.(937-939)tCc>tTc	p.S313F	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	313	30 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						CCCTCCTCCTCCGTGTCCCTC	0.692000													10	118					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30398934	30398934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30398934G>A	ENST00000333027.3	+	9	951	c.623G>A	c.(622-624)aGt>aAt	p.S208N	MTMR3_ENST00000401950.2_Missense_Mutation_p.S208N|MTMR3_ENST00000323630.5_Missense_Mutation_p.S72N|MTMR3_ENST00000406629.1_Missense_Mutation_p.S208N|MTMR3_ENST00000351488.3_Missense_Mutation_p.S208N	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	208	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			GAACTGGAAAGTGTATCAAGT	0.507000													37	77					0	0	1	0	0
LHFPL1	340596	broad.mit.edu	37	X	111914257	111914257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:111914257C>T	ENST00000371968.3	-	2	601	c.362G>A	c.(361-363)gGa>gAa	p.G121E	LHFPL1_ENST00000536453.1_Missense_Mutation_p.G121E|LHFPL1_ENST00000478229.1_Intron	NM_178175.3	NP_835469.1	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1	121						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)	13						CTGCGCTGCTCCCATGCAACG	0.577000													26	14					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183895291	183895291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183895291G>A	ENST00000304685.3	+	19	2738	c.2277G>A	c.(2275-2277)gtG>gtA	p.V759V	RGL1_ENST00000360851.3_Silent_p.V724V|RGL1_ENST00000536277.1_Silent_p.V722V|RGL1_ENST00000367531.1_Silent_p.V759V|RGL1_ENST00000539189.1_Silent_p.V695V	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	724					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						ACAGCCAAGTGAACTTTGACT	0.453000													45	124					0	0	1	0	0
SIX1	6495	broad.mit.edu	37	14	61115508	61115508	+	Missense_Mutation	SNP	T	T	C	rs80356460		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:61115508T>C	ENST00000247182.6	-	1	672	c.400A>G	c.(400-402)Aag>Gag	p.K134E	SIX1_ENST00000554986.1_Intron	NM_005982.3	NP_005973.1	Q15475	SIX1_HUMAN	SIX homeobox 1	134					branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		CCCCTCGACTTCTCCTTGAAG	0.662000													31	55					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31533801	31533801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31533801G>A	ENST00000215885.3	-	4	1213	c.961C>T	c.(961-963)Ccc>Tcc	p.P321S		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	321					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						GCTTTGCTGGGGCGCTTGGAC	0.652000													69	162					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066331	9066331	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9066331A>T	ENST00000397910.4	-	3	21318	c.21115T>A	c.(21115-21117)Tct>Act	p.S7039T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7041	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGAGGTAGACCCAGAAGGA	0.483000													52	140					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69669255	69669255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69669255C>T	ENST00000194900.4	+	4	850	c.509C>T	c.(508-510)cCc>cTc	p.P170L	DLG3_ENST00000374360.3_Missense_Mutation_p.P152L			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	152	PDZ 1.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					ATCGACAATCCCCATGTCCCT	0.567000													29	20					0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77456024	77456024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:77456024C>T	ENST00000299543.7	+	3	593	c.446C>T	c.(445-447)aCc>aTc	p.T149I	CTDP1_ENST00000075430.7_Missense_Mutation_p.T149I	NM_001202504.1|NM_004715.4	NP_001189433.1|NP_004706.3	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	149					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		TCCACGGCGACCGTGTCCATG	0.622000													10	27					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77702316	77702316	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:77702316G>A	ENST00000534064.1	-	2	118	c.84C>T	c.(82-84)ctC>ctT	p.L28L	INTS4_ENST00000529807.1_Silent_p.L28L|INTS4_ENST00000527522.1_Silent_p.L28L	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	28					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TTGTTAGTCGGAGTTTCTTAG	0.428000													42	92					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153884264	153884264	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:153884264C>T	ENST00000511601.1	+	8	1199	c.1011C>T	c.(1009-1011)ctC>ctT	p.L337L	FHDC1_ENST00000260008.3_Silent_p.L337L			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	337	FH2.				actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GGATGAATCTCCTGCACTTTG	0.438000													48	99					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50324451	50324451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50324451C>T	ENST00000394697.2	+	3	595	c.255C>T	c.(253-255)gtC>gtT	p.V85V	ADCY7_ENST00000537579.1_Silent_p.V85V|ADCY7_ENST00000538642.1_Silent_p.V85V|ADCY7_ENST00000254235.3_Silent_p.V85V|ADCY7_ENST00000564044.1_Intron|ADCY7_ENST00000566433.2_Silent_p.V85V			P51828	ADCY7_HUMAN	adenylate cyclase 7	85					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TGATGTACGTCGAGTGTCTCC	0.642000													29	52					0	0	1	0	0
STAC3	246329	broad.mit.edu	37	12	57643365	57643365	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57643365G>A	ENST00000332782.2	-	2	256	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W	STAC3_ENST00000554578.1_Intron|STAC3_ENST00000546246.2_Intron	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	19					intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						CCACTTTGCCGAGTCTCTGCT	0.522000													27	67					0	0	1	0	0
CHAT	1103	broad.mit.edu	37	10	50857597	50857597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50857597G>A	ENST00000395562.2	+	11	1649	c.1180G>A	c.(1180-1182)Gag>Aag	p.E394K	CHAT_ENST00000395559.2_Missense_Mutation_p.E358K|CHAT_ENST00000455728.2_Missense_Mutation_p.E358K|CHAT_ENST00000337653.2_Missense_Mutation_p.E476K|CHAT_ENST00000351556.3_Missense_Mutation_p.E358K|CHAT_ENST00000339797.1_Missense_Mutation_p.E358K	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	476					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CTCCGTCAGCGAGCTCCCCGC	0.617000													16	68					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28755047	28755047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:28755047C>T	ENST00000422425.2	+	9	585	c.541C>T	c.(541-543)Ccc>Tcc	p.P181S	PLB1_ENST00000327757.5_Missense_Mutation_p.P181S	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	181	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TTACCTGTGCCCCTCTGCTCA	0.478000													33	158					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134916263	134916263	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134916263G>A	ENST00000607359.1	+	14	2478	c.2478G>A	c.(2476-2478)agG>agA	p.R826R	GPR123_ENST00000392606.2_Silent_p.R9R|GPR123_ENST00000392607.3_Silent_p.R106R			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	106						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		TGACCGCCAGGAACATCTACA	0.622000													5	28					0	0	1	0	0
OR14I1	401994	broad.mit.edu	37	1	248845324	248845324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248845324G>A	ENST00000342623.3	-	1	305	c.282C>T	c.(280-282)ggC>ggT	p.G94G		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G94G(1)		NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						GAGCCACACAGCCAAGATAAG	0.488000													8	40					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145894735	145894735	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145894735C>T	ENST00000311104.2	-	1	1018	c.942G>A	c.(940-942)agG>agA	p.R314R		NM_194251.2	NP_919227.2	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	314						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAAGCCTTCCCTGAACTCTT	0.468000													10	45					0	0	1	0	0
CSTF1	1477	broad.mit.edu	37	20	54978716	54978716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:54978716C>T	ENST00000217109.4	+	6	1581	c.1229C>T	c.(1228-1230)cCc>cTc	p.P410L	CSTF1_ENST00000493039.1_3'UTR	NM_001033521.1|NM_001324.2	NP_001028693.1|NP_001315.1	Q05048	CSTF1_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa	410					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	15			Colorectal(105;0.202)			CCCACCAACCCCGGGTTCATG	0.577000													30	98					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172504301	172504301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172504301C>T	ENST00000417960.1	+	18	2225	c.1748C>T	c.(1747-1749)gCt>gTt	p.A583V	ECT2_ENST00000232458.5_Missense_Mutation_p.A584V|ECT2_ENST00000427830.1_Missense_Mutation_p.A584V|ECT2_ENST00000392692.3_Missense_Mutation_p.A615V|ECT2_ENST00000441497.2_Missense_Mutation_p.A584V|ECT2_ENST00000540509.1_Missense_Mutation_p.A615V	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	584	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AAGCATACAGCTGATGAAAAT	0.318000													9	38					0	0	1	0	0
UIMC1	51720	broad.mit.edu	37	5	176378527	176378527	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176378527G>A	ENST00000377219.2	-	9	1557	c.1391C>T	c.(1390-1392)cCa>cTa	p.P464L	UIMC1_ENST00000377227.4_Missense_Mutation_p.P464L|UIMC1_ENST00000503273.1_5'UTR|UIMC1_ENST00000506128.1_Missense_Mutation_p.P298L|UIMC1_ENST00000511320.1_Missense_Mutation_p.P464L	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	464	Necessary for interaction with NR6A1 C- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTGCTACCTGGAGAGACTTC	0.353000													94	281					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54872769	54872769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54872769G>A	ENST00000391743.3	-	2	344	c.64C>T	c.(64-66)Ccc>Tcc	p.P22S	LAIR1_ENST00000391742.2_Missense_Mutation_p.P40S|LAIR1_ENST00000474878.1_Missense_Mutation_p.P39S|LAIR1_ENST00000434277.2_Missense_Mutation_p.P39S|LAIR1_ENST00000313038.6_Missense_Mutation_p.P33S|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000348231.4_Missense_Mutation_p.P40S			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	40						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		CTCCCCAGGGGGATCACGGTG	0.577000													54	151					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22915379	22915379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22915379C>T	ENST00000166244.3	+	5	1067	c.995C>T	c.(994-996)cCa>cTa	p.P332L	EPHA8_ENST00000374644.4_Missense_Mutation_p.P332L|EPHA8_ENST00000538803.1_Missense_Mutation_p.P332L	NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	332	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCCTCGGCACCAGTGAACCTG	0.587000													22	48					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238277483	238277483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238277483G>A	ENST00000295550.4	-	10	5075	c.4623C>T	c.(4621-4623)ccC>ccT	p.P1541P	COL6A3_ENST00000353578.4_Silent_p.P1335P|COL6A3_ENST00000409809.1_Silent_p.P1335P|COL6A3_ENST00000472056.1_Silent_p.P934P|COL6A3_ENST00000346358.4_Silent_p.P1341P|COL6A3_ENST00000347401.3_Silent_p.P1340P	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1541	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCAGGTGTTGGGGCACCCCGT	0.572000													40	88					0	0	1	0	0
FGF14	2259	broad.mit.edu	37	13	102378965	102378965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:102378965C>T	ENST00000376131.4	-	4	714	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	FGF14_ENST00000376143.4_Missense_Mutation_p.E202K	NM_175929.2	NP_787125.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	202					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TACTCACCTTCCAATGGCTTG	0.358000													12	121					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688164	60688164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:60688164G>A	ENST00000335712.6	-	4	2110	c.1883C>T	c.(1882-1884)tCg>tTg	p.S628L	BCL11A_ENST00000538214.1_Missense_Mutation_p.S594L|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000356842.4_Missense_Mutation_p.S628L|BCL11A_ENST00000537768.1_Missense_Mutation_p.S297L|BCL11A_ENST00000358510.4_Missense_Mutation_p.S594L	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	628					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GGGGCTCAGCGAGCTGGGGCT	0.662000			T	IGH@	B-CLL								18	35					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59323895	59323895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:59323895C>T	ENST00000348370.4	+	2	1307	c.874C>T	c.(874-876)Ccc>Tcc	p.P292S	RNF111_ENST00000559209.1_Missense_Mutation_p.P292S|RNF111_ENST00000557998.1_Missense_Mutation_p.P292S|RNF111_ENST00000561186.1_Missense_Mutation_p.P292S|RNF111_ENST00000434298.1_Missense_Mutation_p.P292S	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	292	Interaction with AXIN1.|Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		TCCAGCTGTTCCCTCAGGTAA	0.368000													37	92					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61819614	61819614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61819614G>A	ENST00000373827.2	-	40	5059	c.4889C>T	c.(4888-4890)cCt>cTt	p.P1630L	ANK3_ENST00000355288.2_Missense_Mutation_p.P770L|RP11-388P9.2_ENST00000414383.1_RNA|ANK3_ENST00000503366.1_Missense_Mutation_p.P1637L|ANK3_ENST00000280772.1_Intron	NM_001204403.1	NP_001191332.1	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3687	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCCCTGGGAAGGCACTAGCCC	0.478000													29	125					0	0	1	0	0
NCALD	83988	broad.mit.edu	37	8	102731543	102731543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:102731543G>A	ENST00000395923.1	-	4	774	c.315C>T	c.(313-315)ttC>ttT	p.F105F	NCALD_ENST00000519508.2_Silent_p.F105F|NCALD_ENST00000521599.1_Silent_p.F105F|NCALD_ENST00000311028.3_Silent_p.F105F|NCALD_ENST00000220931.6_Silent_p.F105F|NCALD_ENST00000522951.1_Silent_p.F105F	NM_001040627.1|NM_001040628.1|NM_001040629.1|NM_001040630.1	NP_001035717.1|NP_001035718.1|NP_001035719.1|NP_001035720.1	P61601	NCALD_HUMAN	neurocalcin delta	105	EF-hand 3.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)	8	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			CGTACATGCTGAAGGCCCATT	0.478000													47	134					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11186751	11186751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11186751G>A	ENST00000361445.4	-	46	6530	c.6454C>T	c.(6454-6456)Cgc>Tgc	p.R2152C	MTOR_ENST00000376838.1_Missense_Mutation_p.R357C	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2152					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GACTGAATGCGAATGATTGGC	0.493000													34	74					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167301376	167301376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167301376C>T	ENST00000409855.1	-	12	1648	c.1522G>A	c.(1522-1524)Gat>Aat	p.D508N		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	508					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						AGGAAAAGATCAGTAAATGGT	0.328000													12	31					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76118722	76118722	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76118722G>A	ENST00000590602.1	-	10	1350	c.1191C>T	c.(1189-1191)tcC>tcT	p.S397S	TMC6_ENST00000591436.1_Silent_p.S36S|TMC6_ENST00000306591.7_Silent_p.S397S|TMC6_ENST00000322933.4_Silent_p.S36S|TMC6_ENST00000322914.3_Silent_p.S397S|TMC6_ENST00000589553.1_Silent_p.S170S|TMC6_ENST00000392467.3_Silent_p.S397S|TMC6_ENST00000592076.1_5'UTR			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	397						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GCTGGAGGCGGGAGGCCCGCT	0.662000													6	18					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130763803	130763803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:130763803C>T	ENST00000276708.4	-	10	1809	c.928G>A	c.(928-930)Gaa>Aaa	p.E310K		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	310						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CAGAAGGGTTCCTCTATTCTT	0.478000													33	80					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18702854	18702854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18702854G>A	ENST00000251296.1	+	7	1449	c.1066G>A	c.(1066-1068)Ggg>Agg	p.G356R	IGSF21_ENST00000473951.1_3'UTR	NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	356	Ig-like 2.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		AGCCCGGGTAGGGGACACAGT	0.587000													61	189					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169337945	169337945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169337945G>A	ENST00000511577.1	-	20	2861	c.2614C>T	c.(2614-2616)Cat>Tat	p.H872Y	DDX60L_ENST00000505890.1_Missense_Mutation_p.H872Y|DDX60L_ENST00000260184.7_Missense_Mutation_p.H872Y			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	872	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CCAAGATAATGGACCTAGTAA	0.328000													14	57					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183014925	183014925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183014925G>A	ENST00000328913.3	-	12	1633	c.1336C>T	c.(1336-1338)Ctc>Ttc	p.L446F	B3GNT5_ENST00000462559.1_3'UTR|MCF2L2_ENST00000414362.2_Missense_Mutation_p.L446F|MCF2L2_ENST00000447025.2_Missense_Mutation_p.L446F|MCF2L2_ENST00000473233.1_Missense_Mutation_p.L446F	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	446					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.L446I(1)		breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GAAGCCAAGAGGTAGATTCCT	0.532000													12	64					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48755478	48755478	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48755478C>T	ENST00000285238.8	+	25	3683	c.3603C>T	c.(3601-3603)ttC>ttT	p.F1201F		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1201	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GAGTGGAGTTCGTGGGGAACT	0.602000													55	55					0	0	1	0	0
GIPC1	10755	broad.mit.edu	37	19	14593559	14593559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14593559G>A	ENST00000393033.4	-	4	499	c.230C>T	c.(229-231)aCc>aTc	p.T77I	GIPC1_ENST00000586027.1_Missense_Mutation_p.T77I|GIPC1_ENST00000393028.1_Intron|GIPC1_ENST00000591349.1_Intron|GIPC1_ENST00000393029.3_Intron|GIPC1_ENST00000345425.2_Missense_Mutation_p.T77I	NM_005716.3	NP_005707.1	O14908	GIPC1_HUMAN	GIPC PDZ domain containing family, member 1	77					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						CTTGACGTTGGTGAAGCCCTC	0.677000													9	25					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538718	55538718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55538718G>A	ENST00000220676.1	+	4	2424	c.2276G>A	c.(2275-2277)aGa>aAa	p.R759K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	759					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AATTTCCATAGAAATAAATTA	0.299000													9	29					0	0	1	0	0
MIP	4284	broad.mit.edu	37	12	56847402	56847402	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56847402G>A	ENST00000257979.4	-	2	526	c.498C>T	c.(496-498)ttC>ttT	p.F166F	MIP_ENST00000555551.1_5'UTR	NM_012064.3	NP_036196.1	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	166					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	16						GGGCAAGGGAGAAGCCAACGG	0.567000													27	62					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15885110	15885110	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15885110G>A	ENST00000587443.2	-	0	312					NR_033864.1																						AGGGCTTCAGGAACCTGATGG	0.577000													44	83					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100796698	100796698	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:100796698C>T	ENST00000358544.2	+	43	8121	c.8010C>T	c.(8008-8010)tcC>tcT	p.S2670S	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Silent_p.S2645S	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2670					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTCACAAATCCCCACAGGTAT	0.468000													25	105					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24454272	24454272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24454272C>T	ENST00000230036.1	-	14	1416	c.1306G>A	c.(1306-1308)Gag>Aag	p.E436K		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	436						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						CTGTGGGCCTCCTTGTCCAGG	0.562000													7	112					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34235964	34235964	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34235964G>A	ENST00000587132.1	-	0	2063																											TTTGGATGCTGAGCCTGGTTC	0.478000													26	38					0	0	1	0	0
LYPD3	27076	broad.mit.edu	37	19	43965559	43965559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43965559G>A	ENST00000244333.3	-	5	1073	c.985C>T	c.(985-987)Ccc>Tcc	p.P329S		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	329						anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				CCAGCTGTGGGAGCCACACAG	0.602000													12	29					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54793667	54793667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54793667G>A	ENST00000293379.4	-	26	2969	c.2708C>T	c.(2707-2709)tCc>tTc	p.S903F	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	903					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						AGGTCCCGAGGAAGCAGAGCT	0.552000											OREG0021897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	120					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18039118	18039118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18039118G>A	ENST00000205890.5	+	13	4914	c.4576G>A	c.(4576-4578)Gcc>Acc	p.A1526T		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1526	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CCTGCAGAAGGCCATCACCTT	0.592000													4	22					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6635479	6635479	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6635479C>T	ENST00000315579.5	+	20	3307	c.2508C>T	c.(2506-2508)ccC>ccT	p.P836P	NCAPD2_ENST00000545962.1_Silent_p.P791P|NCAPD2_ENST00000542492.1_3'UTR	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	836					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						GTCACCCCCCCTTCCGGCTGC	0.567000													34	73					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15063777	15063777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15063777C>T	ENST00000430939.2	-	8	1399	c.1270G>A	c.(1270-1272)Gaa>Aaa	p.E424K	SLC1A6_ENST00000221742.3_Missense_Mutation_p.E488K|SLC1A6_ENST00000600144.1_Missense_Mutation_p.E410K			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	488					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	GTGATGTCTTCCGTGGGCAAG	0.602000													52	116					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118506066	118506066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:118506066C>T	ENST00000311085.8	+	24	5660	c.5580C>T	c.(5578-5580)acC>acT	p.T1860T	DMXL1_ENST00000539542.1_Silent_p.T1860T	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1860										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TATTTTTTACCACTGCCAGTG	0.368000													11	41					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45281206	45281206	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45281206C>T	ENST00000270279.3	+	1	81	c.18C>T	c.(16-18)gcC>gcT	p.A6A	CBLC_ENST00000341505.4_Silent_p.A6A	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	6					cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				TGGCGGTGGCCCCGTGGGGGC	0.716000			M		AML								9	15					0	0	1	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135758808	135758808	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135758808C>T	ENST00000250617.6	-	18	3125	c.1920G>A	c.(1918-1920)tcG>tcA	p.S640S	ARHGEF6_ENST00000535227.1_Silent_p.S513S|ARHGEF6_ENST00000370622.1_Silent_p.S486S|ARHGEF6_ENST00000370620.1_Silent_p.S486S	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	640					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.S640S(1)		cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					ATTCCTCCTCCGATGGTTTTC	0.323000													22	11					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91469768	91469768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:91469768C>T	ENST00000416354.1	+	5	508	c.436C>T	c.(436-438)Cgt>Tgt	p.R146C	KIF20B_ENST00000394289.2_Missense_Mutation_p.R146C|KIF20B_ENST00000371728.3_Missense_Mutation_p.R146C|KIF20B_ENST00000260753.4_Missense_Mutation_p.R146C			Q96Q89	KI20B_HUMAN	kinesin family member 20B	146	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						AGGACAGAGTCGTCTGATTTT	0.353000													58	105					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196749452	196749452	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196749452G>A	ENST00000312428.6	-	35	5720	c.5620C>T	c.(5620-5622)Cga>Tga	p.R1874*		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1874					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATTAGTTCTCGAAGAATCTTA	0.383000													28	51					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62329940	62329940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62329940G>A	ENST00000371158.2	+	20	2584	c.2470G>A	c.(2470-2472)Gaa>Aaa	p.E824K	INADL_ENST00000316485.6_Missense_Mutation_p.E824K	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	824					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TTTTAAAGAAGAACTTGTGGA	0.373000													15	75					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9864374	9864374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:9864374C>T	ENST00000380913.3	+	4	2516	c.2426C>T	c.(2425-2427)cCc>cTc	p.P809L		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	809					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				AAACCTGTTCCCCAGAGGCCT	0.602000													31	13					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435691	158435691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158435691C>T	ENST00000289451.2	+	1	420	c.340C>T	c.(340-342)Ctg>Ttg	p.L114L		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TCACTCCTTCCTGCTGGCAGC	0.527000													38	176					0	0	1	0	0
RAX	30062	broad.mit.edu	37	18	56939816	56939816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56939816C>T	ENST00000334889.3	-	2	506	c.320G>A	c.(319-321)gGg>gAg	p.G107E	RAX_ENST00000256852.7_Intron	NM_013435.2	NP_038463.2	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	107				G -> W (in Ref. 1; AAD23438).	visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)		CCGTGCCTCCCCGGGCTCCTT	0.701000													16	56					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088013	86088013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:86088013G>A	ENST00000330753.4	+	2	922	c.155G>A	c.(154-156)cGa>cAa	p.R52Q	FLRT2_ENST00000554746.1_Missense_Mutation_p.R52Q	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	52	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGTAATGAGCGAAGCTTGACC	0.517000													45	103					0	0	1	0	0
LRRC4B	94030	broad.mit.edu	37	19	51020884	51020884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51020884C>T	ENST00000599957.1	-	3	2283	c.2086G>A	c.(2086-2088)Gaa>Aaa	p.E696K	LRRC4B_ENST00000389201.3_Missense_Mutation_p.E696K			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	696						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AGCAGAGGTTCGTGGATGGAG	0.697000													10	25					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153554	5153554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5153554G>A	ENST00000307388.1	-	1	318	c.319C>T	c.(319-321)Cac>Tac	p.H107Y		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGAATGAGTGAATAAGCCAC	0.448000													6	56					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141473643	141473643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141473643G>A	ENST00000389484.3	-	37	6893	c.5922C>T	c.(5920-5922)ttC>ttT	p.F1974F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1974					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAATTAAGTTGAAACCATGAT	0.333000										TSP Lung(27;0.18)			36	116					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118203949	118203949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118203949C>T	ENST00000369230.3	+	4	526	c.380C>T	c.(379-381)tCa>tTa	p.S127L		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	127					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		ATCAACGGTTCACGGGAATAC	0.333000													43	69					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174230	51174230	+	Missense_Mutation	SNP	G	G	A	rs61731136	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51174230G>A	ENST00000440970.1	-	2	2043	c.1612C>T	c.(1612-1614)Ccg>Tcg	p.P538S	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.P635S	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	635					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTCGCCGTCGGGACTGAGTTG	0.632000													24	47					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670757	131670757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131670757C>T	ENST00000259324.5	+	3	1837	c.1314C>T	c.(1312-1314)atC>atT	p.I438I	LRRC8A_ENST00000372600.4_Silent_p.I438I|LRRC8A_ENST00000372599.3_Silent_p.I438I	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	438					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						TCAGTGGCATCCCTGACACTG	0.612000													9	26					0	0	1	0	0
AMN	81693	broad.mit.edu	37	14	103396997	103396997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103396997G>A	ENST00000299155.5	+	12	1375	c.1342G>A	c.(1342-1344)Ggg>Agg	p.G448R		NM_030943.3	NP_112205.2	Q9BXJ7	AMNLS_HUMAN	amnion associated transmembrane protein	448					lipid metabolic process|lipoprotein metabolic process|multicellular organismal development	integral to membrane|plasma membrane				kidney(2)|large_intestine(1)|lung(2)|skin(1)	6				Colorectal(3;0.00739)|READ - Rectum adenocarcinoma(2;0.0336)|Epithelial(152;0.0363)|all cancers(159;0.147)	Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCTGTTCGCCGGGGCCGAGGC	0.716000													6	11					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9352995	9352995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9352995G>A	ENST00000378501.2	+	8	646	c.631G>A	c.(631-633)Gaa>Aaa	p.E211K	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.E211K|PLCB4_ENST00000278655.4_Missense_Mutation_p.E211K|PLCB4_ENST00000378493.1_Missense_Mutation_p.E211K|PLCB4_ENST00000334005.3_Missense_Mutation_p.E211K|PLCB4_ENST00000378473.3_Missense_Mutation_p.E211K	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	211					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AAAGTTCTATGAACTGACACA	0.338000													13	83					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70079799	70079799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70079799C>T	ENST00000446444.1	-	1	650	c.642G>A	c.(640-642)atG>atA	p.M214I	RP11-704M14.1_ENST00000505646.1_RNA|RP11-704M14.1_ENST00000504301.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	214					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						GCACATAGATCATATTTTTTA	0.343000													23	57					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8660990	8660990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8660990G>A	ENST00000270328.4	-	10	1570	c.1304C>T	c.(1303-1305)tCc>tTc	p.S435F	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.S435F			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	435	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						ACGGCTGCAGGATGACCACAC	0.597000													51	97					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7042193	7042193	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:7042193G>A	ENST00000389658.3	-	9	1305	c.1212C>T	c.(1210-1212)tcC>tcT	p.S404S		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	404	Laminin EGF-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGAACTGAGGGACCCCACAG	0.448000													10	30					0	0	1	0	0
C2orf43	60526	broad.mit.edu	37	2	20939734	20939734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:20939734G>A	ENST00000237822.3	-	5	779	c.700C>T	c.(700-702)Ctt>Ttt	p.L234F	C2orf43_ENST00000541941.1_Missense_Mutation_p.L104F|C2orf43_ENST00000435420.2_Missense_Mutation_p.L186F|C2orf43_ENST00000403006.2_Missense_Mutation_p.L104F|C2orf43_ENST00000381090.3_Missense_Mutation_p.L234F|C2orf43_ENST00000440866.2_Intron	NM_021925.2	NP_068744.1	Q9H6V9	CB043_HUMAN	chromosome 2 open reading frame 43	234										endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTTACCAAGGCAGAATGGT	0.348000													16	78					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219254613	219254613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219254613C>T	ENST00000233202.6	+	9	1156	c.816C>T	c.(814-816)gcC>gcT	p.A272A	SLC11A1_ENST00000539932.1_Silent_p.A154A	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	272					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGACCGGGCCCGCCGAGCAG	0.537000													15	26					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152433	18152433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18152433G>A	ENST00000375406.1	+	3	736	c.520G>A	c.(520-522)Gag>Aag	p.E174K		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	174						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CAAGACGCTGGAGTTCGCCGG	0.617000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	26					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65684548	65684548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65684548G>A	ENST00000352385.2	-	11	2255	c.2046C>T	c.(2044-2046)ggC>ggT	p.G682G		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	682	Fibronectin type-III 3.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GGTCTCCACGGCCCCCTGGCA	0.647000													23	77					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43376150	43376150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43376150C>T	ENST00000244296.2	-	3	615	c.478G>A	c.(478-480)Gag>Aag	p.E160K	PSG1_ENST00000312439.6_Missense_Mutation_p.E160K|PSG1_ENST00000436291.2_Missense_Mutation_p.E160K|PSG1_ENST00000403380.3_Intron|PSG1_ENST00000595124.1_Intron|PSG1_ENST00000595356.1_Missense_Mutation_p.E160K	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				TCCATGGTCTCCCTGGGATTT	0.537000													81	200					0	0	1	0	0
DAK	26007	broad.mit.edu	37	11	61106811	61106811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61106811C>T	ENST00000394900.3	+	5	619	c.390C>T	c.(388-390)atC>atT	p.I130I		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	130	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						CTGAAGGCATCCCGGTGGAGA	0.652000													14	113					0	0	1	0	0
GTF3C5	9328	broad.mit.edu	37	9	135919191	135919191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135919191C>T	ENST00000372097.5	+	3	773	c.450C>T	c.(448-450)ctC>ctT	p.L150L	GTF3C5_ENST00000372099.6_Silent_p.L141L|GTF3C5_ENST00000372108.5_Silent_p.L150L|GTF3C5_ENST00000342018.8_Silent_p.L150L|GTF3C5_ENST00000485692.1_3'UTR|GTF3C5_ENST00000372095.5_Silent_p.L25L	NM_012087.3	NP_036219.2	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5, 63kDa	150						transcription factor TFIIIC complex	DNA binding|protein binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		ACAAGGTGCTCATGCTCCGGC	0.582000													14	114					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53070861	53070861	+	Silent	SNP	G	G	A	rs137978741		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53070861G>A	ENST00000252244.3	-	6	1294	c.1236C>T	c.(1234-1236)atC>atT	p.I412I		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	412	Coil 2.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						TGACATTGTCGATTTCAGATC	0.453000													38	43					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111969148	111969148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111969148G>A	ENST00000369732.3	-	3	226	c.171C>T	c.(169-171)gcC>gcT	p.A57A	OVGP1_ENST00000540696.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	57					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TTGAGGCAAAGGCAAATATCA	0.483000													17	82					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20482391	20482391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20482391C>T	ENST00000504154.1	+	6	772	c.520C>T	c.(520-522)Ctc>Ttc	p.L174F	SLIT2_ENST00000273739.5_Missense_Mutation_p.L174F|SLIT2_ENST00000503823.1_Missense_Mutation_p.L174F|SLIT2_ENST00000503837.1_Missense_Mutation_p.L174F	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	174					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ATTCAGGGCTCTCCGGGACCT	0.448000													27	111					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38051357	38051357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38051357C>T	ENST00000357436.4	+	18	2085	c.1772C>T	c.(1771-1773)cCc>cTc	p.P591L	SH3BP1_ENST00000599616.1_Intron|Z83844.1_ENST00000456099.1_RNA	NM_018957.3	NP_061830.3	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	591					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					CCAGCCCCGCCCTTGCCCCCT	0.741000													6	8					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71153328	71153328	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71153328C>T	ENST00000355527.3	-	5	669	c.393G>A	c.(391-393)gaG>gaA	p.E131E	DHCR7_ENST00000407721.2_Silent_p.E131E	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	131					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	TCACGGCCCCCTCCTGGATGC	0.602000									Smith-Lemli-Opitz syndrome				5	11					0	0	1	0	0
AK5	26289	broad.mit.edu	37	1	77984380	77984380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:77984380G>A	ENST00000344720.5	+	11	2227	c.1201G>A	c.(1201-1203)Gac>Aac	p.D401N	AK5_ENST00000354567.2_Missense_Mutation_p.D427N	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	427					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						ATTGATCAGAGACATTATGGA	0.468000													13	48					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30936219	30936219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30936219C>T	ENST00000355537.3	+	2	1897	c.1750C>T	c.(1750-1752)Cac>Tac	p.H584Y		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGATTTGGTTCACAGCACTAA	0.517000													23	77					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72346877	72346877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:72346877C>T	ENST00000299687.5	+	1	3902	c.3902C>T	c.(3901-3903)cCc>cTc	p.P1301L	ZNF407_ENST00000309902.6_Missense_Mutation_p.P1301L|ZNF407_ENST00000582337.1_Missense_Mutation_p.P1301L|ZNF407_ENST00000577538.1_Missense_Mutation_p.P1301L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CAAGAAGATCCCGTTCTGGGG	0.448000													6	32					0	0	1	0	0
SPATA19	219938	broad.mit.edu	37	11	133714141	133714141	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:133714141C>T	ENST00000299140.3	-	4	413	c.359_splice	c.e4+1	p.S120_splice	SPATA19_ENST00000532889.1_Splice_Site_p.S120_splice	NM_174927.1	NP_777587.1	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19	120					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane				cervix(1)|endometrium(2)|large_intestine(2)|lung(5)|prostate(1)	11	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GACACCTTACCTCCATCTTAT	0.527000													29	87					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74592677	74592677	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74592677C>T	ENST00000361874.3	-	25	3311	c.2994G>A	c.(2992-2994)ctG>ctA	p.L998L	DCTN1_ENST00000407639.2_Silent_p.L864L|DCTN1_ENST00000409567.3_Silent_p.L978L|DCTN1_ENST00000394003.3_Silent_p.L991L|DCTN1_ENST00000409438.1_Silent_p.L864L|DCTN1_ENST00000409240.1_Silent_p.L961L|DCTN1_ENST00000409868.1_Silent_p.L981L	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	998					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						GGGTCTCCTCCAGCCGAGTCT	0.577000													12	43					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3844784	3844784	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3844784G>A	ENST00000309890.7	-	13	1860	c.1710C>T	c.(1708-1710)ccC>ccT	p.P570P	ATP2A3_ENST00000352011.3_Silent_p.P570P|ATP2A3_ENST00000359983.3_Silent_p.P570P|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397041.3_Silent_p.P570P|ATP2A3_ENST00000397035.3_Silent_p.P570P|ATP2A3_ENST00000397043.3_Silent_p.P570P	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	570					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCTTCCTTGGGGGCGCGTCCC	0.647000													28	77					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102477166	102477166	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102477166C>T	ENST00000360184.4	+	32	6659	c.6495C>T	c.(6493-6495)ttC>ttT	p.F2165F		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2165					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CGGACGTGTTCCCTGGAGTCC	0.532000													25	107					0	0	1	0	0
GHRHR	2692	broad.mit.edu	37	7	31008470	31008470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31008470G>A	ENST00000326139.2	+	2	125	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K		NM_000823.3	NP_000814.2	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	27					activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			biliary_tract(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35					Sermorelin(DB00010)	CATGCACCCAGAATGTGACTT	0.547000													12	48					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128454708	128454708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128454708C>T	ENST00000297788.4	+	15	3147	c.2780C>T	c.(2779-2781)aCc>aTc	p.T927I	CCDC136_ENST00000471729.1_3'UTR|CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000487361.1_Intron|CCDC136_ENST00000464832.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	927						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GAACTGCAGACCAAGCTGCGG	0.587000													12	32					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218940147	218940147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:218940147G>A	ENST00000374155.3	+	8	1402	c.992G>A	c.(991-993)gGg>gAg	p.G331E	RUFY4_ENST00000344321.7_Missense_Mutation_p.G311E|RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000463872.1_3'UTR			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	311							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GAGGTGATAGGGATGGAGGCT	0.572000													6	19					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13386683	13386683	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13386683G>A	ENST00000360228.5	-	24	3969	c.3970C>T	c.(3970-3972)Ctg>Ttg	p.L1324L	CACNA1A_ENST00000573710.2_Silent_p.L1325L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1325					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AAGGCTACCAGGGCCCCACTG	0.562000													12	28					0	0	1	0	0
OR51I2	390064	broad.mit.edu	37	11	5475583	5475583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5475583C>T	ENST00000341449.2	+	1	946	c.865C>T	c.(865-867)Cct>Tct	p.P289S	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTGCTCAACCCTCTCATTTA	0.463000													48	148					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52603813	52603813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52603813C>T	ENST00000395489.2	-	6	544	c.148G>A	c.(148-150)Gaa>Aaa	p.E50K	A1CF_ENST00000395495.1_Missense_Mutation_p.E57K|A1CF_ENST00000373993.1_Missense_Mutation_p.E57K|A1CF_ENST00000374001.1_Missense_Mutation_p.E57K|A1CF_ENST00000373995.3_Missense_Mutation_p.E65K|A1CF_ENST00000373997.3_Missense_Mutation_p.E57K|A1CF_ENST00000282641.2_Missense_Mutation_p.E57K	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	57					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ATAAAAATTTCACAGCCCCTT	0.428000													30	115					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48370644	48370644	+	Missense_Mutation	SNP	G	G	A	rs138519620	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48370644G>A	ENST00000395702.2	+	2	339	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	ZNF488_ENST00000494156.1_Missense_Mutation_p.E38K|ZNF488_ENST00000586537.1_5'UTR			Q96MN9	ZN488_HUMAN	zinc finger protein 488	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						GCGACTTAGCGAACCTGAGCT	0.667000													38	92					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77389943	77389943	+	Missense_Mutation	SNP	G	G	A	rs149929752		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77389943G>A	ENST00000282849.5	-	9	1772	c.1354C>T	c.(1354-1356)Ccc>Tcc	p.P452S		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	452	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.P452S(2)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTTCTGCAGGGATTCCCTTCT	0.428000													41	65					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182412572	182412572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182412572C>T	ENST00000410087.3	-	9	1236	c.1136G>A	c.(1135-1137)aGg>aAg	p.R379K	CERKL_ENST00000409440.3_Missense_Mutation_p.R361K|CERKL_ENST00000374969.2_Missense_Mutation_p.R266K|CERKL_ENST00000374970.2_Missense_Mutation_p.R310K|CERKL_ENST00000339098.5_Missense_Mutation_p.R405K|CERKL_ENST00000479558.1_5'UTR	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	405					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity	p.R405M(1)|p.R379M(1)		NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TCCCTGTGCCCTCCTAAAAGA	0.393000													62	129					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105509965	105509965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:105509965G>A	ENST00000276654.5	-	5	923	c.815C>T	c.(814-816)tCt>tTt	p.S272F	LRP12_ENST00000424843.2_Missense_Mutation_p.S253F	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	272	CUB 2.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding	p.S272F(1)		NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATAATTGGGAGAATTAAAAGT	0.398000													26	53					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880393	74880393	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74880393C>T	ENST00000289575.5	+	5	1019	c.624C>T	c.(622-624)ccC>ccT	p.P208P	SLCO2B1_ENST00000532236.1_Silent_p.P92P|SLCO2B1_ENST00000525650.1_Silent_p.P64P|SLCO2B1_ENST00000526660.1_Intron|SLCO2B1_ENST00000341411.4_Intron|SLCO2B1_ENST00000454962.2_Intron|SLCO2B1_ENST00000531756.1_Intron|SLCO2B1_ENST00000428359.2_Silent_p.P186P	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	208					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	CCATTCAGCCCTTTGGCATCT	0.597000													21	78					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833228	24833228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24833228G>A	ENST00000376451.2	+	14	4338	c.4078G>A	c.(4078-4080)Gaa>Aaa	p.E1360K	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000376454.3_Missense_Mutation_p.E1677K|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000396446.1_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1677					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TAAACAGCTCGAAAATACAAT	0.433000													24	60					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177247899	177247899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177247899C>T	ENST00000361539.4	+	7	1525	c.1213C>T	c.(1213-1215)Cgc>Tgc	p.R405C	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		405						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						TCGCCAGCCTCGCTTCCGCCT	0.617000													21	65					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	711134	711134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:711134C>T	ENST00000382303.1	+	7	1020	c.368C>T	c.(367-369)cCc>cTc	p.P123L	KANK1_ENST00000382297.2_Missense_Mutation_p.P123L|KANK1_ENST00000382293.3_5'UTR|KANK1_ENST00000489369.1_3'UTR	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	123					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		AAGCCACCTCCCCCTCTGGAG	0.502000													54	57					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54687453	54687453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54687453G>A	ENST00000245615.1	-	5	924	c.444C>T	c.(442-444)tcC>tcT	p.S148S	MBOAT7_ENST00000338624.6_Silent_p.S75S|MBOAT7_ENST00000431666.2_Silent_p.S75S|MBOAT7_ENST00000474910.1_5'UTR|MBOAT7_ENST00000391754.1_Silent_p.S148S	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	148					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCTCCATCAGGGAGGGCACGT	0.612000													7	78					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20636224	20636224	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20636224G>A	ENST00000525748.1	+	6	1258		c.e6-1			NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5						synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CTCCTAAACAGATTCCTGTGT	0.393000													38	105					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42880627	42880627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42880627C>T	ENST00000334370.4	+	41	8672	c.8037C>T	c.(8035-8037)ccC>ccT	p.P2679P	MEGF8_ENST00000378073.4_Silent_p.P340P|MEGF8_ENST00000251268.6_Silent_p.P2746P	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2746						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CCTGGGGACCCATGGGAGGGG	0.726000													6	4					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89671687	89671687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89671687C>T	ENST00000264344.5	-	15	2035	c.1828G>A	c.(1828-1830)Gaa>Aaa	p.E610K	FAM13A_ENST00000508369.1_Missense_Mutation_p.E284K|FAM13A_ENST00000513837.1_Missense_Mutation_p.E256K|FAM13A_ENST00000395002.2_Missense_Mutation_p.E284K|FAM13A_ENST00000503556.1_Missense_Mutation_p.E270K|FAM13A_ENST00000511976.1_Missense_Mutation_p.E196K	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	610					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TCGCTGTCTTCGTCCAGCAGC	0.602000													30	97					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123345767	123345767	+	Silent	SNP	C	C	T	rs141649592	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123345767C>T	ENST00000360772.3	-	31	5361	c.4983G>A	c.(4981-4983)caG>caA	p.Q1661Q	MYLK_ENST00000360304.3_Silent_p.Q1712Q|MYLK_ENST00000354792.5_Silent_p.Q512Q|MYLK_ENST00000475616.1_Silent_p.Q1712Q|MYLK-AS1_ENST00000463408.1_RNA|MYLK_ENST00000346322.5_Silent_p.Q1643Q|MYLK-AS1_ENST00000470449.1_RNA|MYLK_ENST00000359169.1_Silent_p.Q1661Q|MYLK-AS1_ENST00000485162.1_RNA			Q15746	MYLK_HUMAN	myosin light chain kinase	1712	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCTGAAGGCACTGCGTGCAGT	0.507000													11	63					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10893725	10893725	+	Missense_Mutation	SNP	C	C	T	rs145607989	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10893725C>T	ENST00000314646.5	+	6	942	c.778C>T	c.(778-780)Ctc>Ttc	p.L260F	DNM2_ENST00000359692.6_Missense_Mutation_p.L260F|DNM2_ENST00000389253.4_Missense_Mutation_p.L260F|DNM2_ENST00000355667.6_Missense_Mutation_p.L260F|DNM2_ENST00000408974.4_Missense_Mutation_p.L260F|DNM2_ENST00000585892.1_Missense_Mutation_p.L260F			P50570	DYN2_HUMAN	dynamin 2	260					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GAAGTTCTTCCTCTCCCACCC	0.587000			"""F, N, Splice, Mis, O"""		ETP ALL								22	53					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42289183	42289183	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42289183C>T	ENST00000361204.4	+	12	2437	c.2271C>T	c.(2269-2271)tcC>tcT	p.S757S	SREBF2_ENST00000491541.1_3'UTR	NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	757					cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TTCCTGACTCCCTGCGCTGGC	0.602000													27	100					0	0	1	0	0
MMRN2	79812	broad.mit.edu	37	10	88702482	88702482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88702482C>T	ENST00000372027.4	-	6	2132	c.2059G>A	c.(2059-2061)Gag>Aag	p.E687K		NM_024756.2	NP_079032.2	Q9H8L6	MMRN2_HUMAN	multimerin 2	687						extracellular space				breast(1)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|stomach(1)	19						GCGGCCTCCTCGCGGCCCGCG	0.771000													4	2					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207669671	207669671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207669671C>T	ENST00000367049.4	+	1	59	c.59C>T	c.(58-60)cCc>cTc	p.P20L	CR1_ENST00000367050.4_3'UTR|CR1_ENST00000400960.2_Missense_Mutation_p.P20L|CR1_ENST00000367052.1_Missense_Mutation_p.P20L|CR1_ENST00000367053.1_Missense_Mutation_p.P20L|CR1_ENST00000367051.1_Missense_Mutation_p.P20L	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	20					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCCGGTCTCCCCTTCTGCTGC	0.682000													17	28					0	0	1	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35928300	35928300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35928300G>A	ENST00000325722.3	-	8	1450	c.1216C>T	c.(1216-1218)Cgg>Tgg	p.R406W	KIAA0319L_ENST00000485551.1_5'UTR	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	406						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATGGGGGGCCGATTCTTACGG	0.448000													23	64					0	0	1	0	0
ADCK1	57143	broad.mit.edu	37	14	78353570	78353570	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:78353570C>T	ENST00000238561.5	+	5	659	c.560C>T	c.(559-561)tCg>tTg	p.S187L	ADCK1_ENST00000341211.5_Missense_Mutation_p.S119L	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	194	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GCTCAGAGCTCGAAGGACATT	0.617000													25	75					0	0	1	0	0
PSG11	5680	broad.mit.edu	37	19	43519322	43519322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43519322G>A	ENST00000401740.1	-	4	1013	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C	PSG11_ENST00000403486.1_Missense_Mutation_p.R182C|PSG11_ENST00000320078.7_Missense_Mutation_p.R304C|PSG11_ENST00000306322.7_Missense_Mutation_p.R182C			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	304	Ig-like C2-type 2.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				GCTGAGTTACGAGCAGAGCAA	0.458000													119	120					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69536328	69536328	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69536328C>T	ENST00000338206.5	-	1	18	c.9G>A	c.(7-9)ctG>ctA	p.L3L		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	3					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										ACGTCCATTTCAGAGACATCC	0.398000													88	342					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7807996	7807996	+	Missense_Mutation	SNP	C	C	T	rs11465393	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7807996C>T	ENST00000315599.7	-	7	1166	c.1144G>A	c.(1144-1146)Gcc>Acc	p.A382T	CD209_ENST00000601951.1_Missense_Mutation_p.A358T|CD209_ENST00000301357.8_Missense_Mutation_p.A246T|CD209_ENST00000315591.8_Missense_Mutation_p.A358T|CD209_ENST00000204801.8_Missense_Mutation_p.A338T|CD209_ENST00000602261.1_Missense_Mutation_p.A290T|CD209_ENST00000394161.5_Missense_Mutation_p.A146T|CD209_ENST00000593660.1_Missense_Mutation_p.A312T|CD209_ENST00000354397.6_Missense_Mutation_p.A376T|CD209_ENST00000593821.1_Missense_Mutation_p.A246T|CD209_ENST00000394173.4_Missense_Mutation_p.A221T	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	382			A -> S (in dbSNP:rs11465393).		cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.A382T(2)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GAGCAGGAGGCTGCGGACTTT	0.522000													74	165					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141526869	141526869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141526869C>T	ENST00000389484.3	-	35	6642	c.5671G>A	c.(5671-5673)Gga>Aga	p.G1891R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1891					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGAGGTATTCCCCTGATTCCT	0.408000										TSP Lung(27;0.18)			16	84					0	0	1	0	0
GHDC	84514	broad.mit.edu	37	17	40344692	40344692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40344692G>A	ENST00000301671.8	-	4	897	c.456C>T	c.(454-456)gcC>gcT	p.A152A	GHDC_ENST00000587427.1_Silent_p.A152A|GHDC_ENST00000428494.2_Silent_p.A113A|GHDC_ENST00000414034.3_Silent_p.A152A|GHDC_ENST00000593209.1_Silent_p.A152A|GHDC_ENST00000436923.2_Silent_p.A152A			Q8N2G8	GHDC_HUMAN	GH3 domain containing	152						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GCGTCACACGGGCAGTGCGTC	0.637000													20	36					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891892	2891892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:2891892G>A	ENST00000254528.3	+	4	1926	c.1767G>A	c.(1765-1767)acG>acA	p.T589T		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	589					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		TCAACGACACGATGCACAGGA	0.448000													23	34					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108682331	108682331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108682331C>T	ENST00000232603.5	-	27	2811	c.2729G>A	c.(2728-2730)aGa>aAa	p.R910K	MORC1_ENST00000483760.1_Missense_Mutation_p.R889K	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	910					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AGAGATTTTTCTTTTATTTTC	0.328000													34	144					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17415876	17415876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17415876C>T	ENST00000470360.1	+	10	1502	c.1385C>T	c.(1384-1386)tCt>tTt	p.S462F	SLC7A2_ENST00000398090.3_Missense_Mutation_p.S462F|SLC7A2_ENST00000522656.1_Missense_Mutation_p.S423F|SLC7A2_ENST00000494857.1_Missense_Mutation_p.S423F|SLC7A2_ENST00000004531.10_Missense_Mutation_p.S463F			P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	423					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	ATGGCCTACTCTCTGGTGGCA	0.532000													6	69					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600263	92600263	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92600263C>T	ENST00000298047.6	+	21	12032	c.12015C>T	c.(12013-12015)ttC>ttT	p.F4005F	FAT3_ENST00000525166.1_Silent_p.F3855F|FAT3_ENST00000533797.1_Silent_p.F340F|FAT3_ENST00000409404.2_Silent_p.F4005F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4005	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCAGCAGCTTCGCGGAGGTGG	0.662000										TCGA Ovarian(4;0.039)			3	6					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106717498	106717498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:106717498G>A	ENST00000428048.2	-	6	574	c.517C>T	c.(517-519)Cct>Tct	p.P173S	UXS1_ENST00000540130.1_Intron|UXS1_ENST00000409501.3_Intron|UXS1_ENST00000283148.7_Intron|UXS1_ENST00000409032.1_Intron			Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	0					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						CAGAGTGGAGGGAGAGGAGCA	0.532000													26	67					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62417456	62417456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62417456G>A	ENST00000528405.1	-	4	286	c.278C>T	c.(277-279)cCc>cTc	p.P93L	INTS5_ENST00000330574.2_Silent_p.S32S																							TGATTTCCTGGGACAGCTCCT	0.493000													15	55					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172001634	172001634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:172001634C>T	ENST00000358155.4	+	5	858	c.682C>T	c.(682-684)Cgc>Tgc	p.R228C	DNM3_ENST00000367733.2_Missense_Mutation_p.R228C|DNM3_ENST00000367731.1_Missense_Mutation_p.R228C|DNM3_ENST00000520906.1_Missense_Mutation_p.R228C|DNM3_ENST00000355305.5_Missense_Mutation_p.R228C	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	228					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GTTGCCTCTTCGCAGGGGTAA	0.393000													26	73					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46727042	46727042	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46727042G>A	ENST00000318962.4	-	7	842	c.759C>T	c.(757-759)ctC>ctT	p.L253L	ALS2CL_ENST00000415953.1_Silent_p.L253L	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	253					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CATCATCAAAGAGCAGCACAC	0.617000													9	30					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385766	33385766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33385766G>A	ENST00000541274.1	-	5	678	c.229C>T	c.(229-231)Cct>Tct	p.P77S	AQP7_ENST00000377425.4_Silent_p.I151I|AQP7_ENST00000537089.1_Silent_p.I116I|AQP7_ENST00000539936.1_Silent_p.I208I			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		TGACCACGAGGATGCCTATCA	0.602000													30	79					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133883997	133883997	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:133883997A>T	ENST00000285928.2	+	14	1640	c.1571A>T	c.(1570-1572)tAt>tTt	p.Y524F		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	524	Guanylate kinase-like.						ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						AAATATTCCTATTTTGAGCCT	0.353000													17	127					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74975996	74975996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74975996G>A	ENST00000261978.4	-	22	3734	c.3348C>T	c.(3346-3348)tcC>tcT	p.S1116S	LTBP2_ENST00000556690.1_Silent_p.S1116S	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1116	Cys-rich.|EGF-like 10; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGTCCTTGCAGGAGAAGGAGC	0.642000													31	100					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55481539	55481539	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55481539G>A	ENST00000543010.1	+	2	299	c.156G>A	c.(154-156)ggG>ggA	p.G52G	NLRP2_ENST00000339757.7_Silent_p.G52G|NLRP2_ENST00000391721.4_Silent_p.G52G|NLRP2_ENST00000427260.2_Intron|NLRP2_ENST00000538819.1_Silent_p.G52G|NLRP2_ENST00000263437.6_Silent_p.G52G|NLRP2_ENST00000537859.1_Silent_p.G52G|NLRP2_ENST00000448584.2_Silent_p.G52G	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	52	DAPIN.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AGGCTGATGGGAAGCAACTGG	0.527000													16	63					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174906	51174906	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51174906G>A	ENST00000440970.1	-	2	1367	c.936C>T	c.(934-936)atC>atT	p.I312I	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.I409I	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	409					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CAGTTGTTCCGATGTTGGGCA	0.478000													37	106					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38537884	38537884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38537884C>T	ENST00000399017.2	+	33	6115	c.3368C>T	c.(3367-3369)cCc>cTc	p.P1123L	TTC3_ENST00000354749.2_Missense_Mutation_p.P1123L|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000355666.1_Missense_Mutation_p.P1123L	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1123					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				GAACATGGTCCCTTGGACATG	0.338000													79	170					0	0	1	0	0
SLC20A2	6575	broad.mit.edu	37	8	42302216	42302216	+	Silent	SNP	G	G	A	rs116687117	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42302216G>A	ENST00000342228.3	-	6	1047	c.678C>T	c.(676-678)ttC>ttT	p.F226F	SLC20A2_ENST00000520179.1_Silent_p.F226F|SLC20A2_ENST00000520262.1_Silent_p.F226F	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	226					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CAAAAAAAGCGAACAGGAGGG	0.493000													31	55					0	0	1	0	0
SUCNR1	56670	broad.mit.edu	37	3	151597688	151597688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151597688G>A	ENST00000362032.4	+	2	113	c.8G>A	c.(7-9)gGg>gAg	p.G3E	RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_033050.4	NP_149039.2	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	3						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	GACATGCTGGGGATCATGGTA	0.343000													16	67					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092435	151092435	+	Missense_Mutation	SNP	C	C	T	rs140138379		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151092435C>T	ENST00000370340.3	+	3	566	c.299C>T	c.(298-300)cCt>cTt	p.P100L	MAGEA4_ENST00000393920.1_Missense_Mutation_p.P100L|MAGEA4_ENST00000393921.1_Missense_Mutation_p.P100L|MAGEA4_ENST00000370337.4_Missense_Mutation_p.P100L|MAGEA4_ENST00000276344.2_Missense_Mutation_p.P100L|MAGEA4_ENST00000360243.2_Missense_Mutation_p.P100L|MAGEA4_ENST00000370335.1_Missense_Mutation_p.P100L			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	100							protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AGCACCTCGCCTGACGCAGAG	0.557000													29	49					0	0	1	0	0
MPV17L2	84769	broad.mit.edu	37	19	18304780	18304780	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18304780C>T	ENST00000599612.2	+	2	394	c.294C>T	c.(292-294)gtC>gtT	p.V98V	MPV17L2_ENST00000534474.2_Silent_p.V98V	NM_032683.2	NP_116072.2	Q567V2	M17L2_HUMAN	MPV17 mitochondrial membrane protein-like 2	98						integral to membrane				large_intestine(1)|lung(2)|urinary_tract(1)	4						TCCCAAATGTCCTCAAGAAGG	0.577000													21	30					0	0	1	0	0
C12orf68	387856	broad.mit.edu	37	12	48578415	48578415	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48578415G>A	ENST00000316554.3	+	1	1050	c.510G>A	c.(508-510)ggG>ggA	p.G170G		NM_001013635.3	NP_001013657.3	Q52MB2	CL068_HUMAN	chromosome 12 open reading frame 68	170						cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)	4						TCCTTGGGGGGGACGGGCCAC	0.652000													4	7					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62718868	62718868	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62718868C>T	ENST00000371153.4	-	8	2931	c.2553G>A	c.(2551-2553)gtG>gtA	p.V851V	KANK4_ENST00000354381.3_Silent_p.V223V|KANK4_ENST00000317477.4_5'UTR|KANK4_ENST00000371150.1_Silent_p.V207V	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	851										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						TCTGATGGTCCACATTGCAGA	0.537000													27	87					0	0	1	0	0
SIX3	6496	broad.mit.edu	37	2	45169955	45169955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:45169955G>A	ENST00000260653.3	+	1	1054	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_005413.3	NP_005404.1	O95343	SIX3_HUMAN	SIX homeobox 3	238					visual perception	nucleus				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|skin(1)	11		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAAGAAACGCGAACTGGCGCA	0.637000													14	69					0	0	1	0	0
SETD7	80854	broad.mit.edu	37	4	140439176	140439176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:140439176G>A	ENST00000274031.3	-	7	1419	c.783C>T	c.(781-783)gcC>gcT	p.A261A	SETD7_ENST00000506866.2_Silent_p.A261A	NM_030648.2	NP_085151.1	Q8WTS6	SETD7_HUMAN	SET domain containing (lysine methyltransferase) 7	261	SET.				peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	8	all_hematologic(180;0.156)					TCCCATTAAGGGCCCAGTCCC	0.488000													8	33					0	0	1	0	0
SYVN1	84447	broad.mit.edu	37	11	64899785	64899785	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64899785G>A	ENST00000526060.1	-	6	657	c.465C>T	c.(463-465)ttC>ttT	p.F155F	SYVN1_ENST00000294256.8_Silent_p.F155F|SYVN1_ENST00000526121.1_5'UTR|SYVN1_ENST00000307289.6_Intron|SYVN1_ENST00000377190.3_Silent_p.F155F			Q86TM6	SYVN1_HUMAN	synovial apoptosis inhibitor 1, synoviolin	155					ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding	p.F155F(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						CGTGGCTGACGAAGAGGAAGT	0.592000													30	70					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141310388	141310388	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141310388C>T	ENST00000325617.5	-	15	2263	c.1823G>A	c.(1822-1824)cGa>cAa	p.R608Q	CLGN_ENST00000414773.1_Missense_Mutation_p.R608Q|CLGN_ENST00000537281.1_Missense_Mutation_p.R608Q	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	608					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					TTAGTCCTTTCGTACTCTTCT	0.373000													30	68					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54186144	54186144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54186144C>T	ENST00000259782.4	+	3	565	c.469C>T	c.(469-471)Cgt>Tgt	p.R157C	TINAG_ENST00000370864.3_Missense_Mutation_p.R139C|TINAG_ENST00000370869.3_Missense_Mutation_p.R153C|TINAG_ENST00000486436.1_3'UTR	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	157					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			ATGCCTTGTTCGTTCAGAATT	0.378000													13	39					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179544834	179544834	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179544834C>T	ENST00000367615.4	-	1	234	c.166G>A	c.(166-168)Gag>Aag	p.E56K	NPHS2_ENST00000367616.4_Missense_Mutation_p.E56K	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	56					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GCTCGGGGCTCCCCCGGGGTC	0.771000													8	8					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204425	56204425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56204425G>A	ENST00000361673.3	-	5	3207	c.2994C>T	c.(2992-2994)tgC>tgT	p.C998C	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	998							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TCGCTTGAAAGCACTCATTAT	0.488000													46	68					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76471470	76471470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76471470C>T	ENST00000389840.5	-	54	8483	c.8359G>A	c.(8359-8361)Ggg>Agg	p.G2787R	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.G2796R					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCGCCCACCCCCACCAGCAGG	0.612000													25	81					0	0	1	0	0
BATF	10538	broad.mit.edu	37	14	76013005	76013005	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76013005C>G	ENST00000286639.6	+	3	627	c.369C>G	c.(367-369)ttC>ttG	p.F123L	BATF_ENST00000555795.1_3'UTR|BATF_ENST00000555504.1_Intron	NM_006399.3	NP_006390.1	Q16520	BATF_HUMAN	basic leucine zipper transcription factor, ATF-like	123						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.028)		CCCCGCGCTTCCAGCCCTGAG	0.697000													6	14					0	0	1	0	0
CLPP	8192	broad.mit.edu	37	19	6364601	6364601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6364601C>T	ENST00000245816.4	+	4	629	c.506C>T	c.(505-507)tCg>tTg	p.S169L	CLPP_ENST00000596605.1_Intron|CLPP_ENST00000596149.1_Missense_Mutation_p.S82L	NM_006012.2	NP_006003.1	Q16740	CLPP_HUMAN	caseinolytic mitochondrial matrix peptidase proteolytic subunit	169					proteolysis	mitochondrial matrix	ATP binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|ovary(2)	6						ATGCGCCACTCGCTCCCCAAC	0.657000													23	36					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	362409	362409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:362409C>T	ENST00000342640.4	-	8	973	c.931G>A	c.(931-933)Gac>Aac	p.D311N	THEG_ENST00000346878.2_Missense_Mutation_p.D287N	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	311					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCACTTGTCCGACTGAGCT	0.592000													38	83					0	0	1	0	0
NRBP1	29959	broad.mit.edu	37	2	27656267	27656267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27656267C>T	ENST00000233557.3	+	3	959	c.127C>T	c.(127-129)Cca>Tca	p.P43S	NRBP1_ENST00000379863.3_Missense_Mutation_p.P43S|NRBP1_ENST00000379852.3_Missense_Mutation_p.P43S			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	43					ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					AGCTGCTTCCCCAGAGGAAGA	0.522000													13	80					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24309442	24309442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:24309442G>A	ENST00000357002.4	+	4	755	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	ZNF254_ENST00000342944.6_Missense_Mutation_p.E129K	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	214					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				CAAATGTAAAGAATGTGGAAA	0.303000													23	106					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72903596	72903596	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72903596G>A	ENST00000339594.4	-	6	1157	c.819C>T	c.(817-819)gtC>gtT	p.V273V	BAZ1B_ENST00000404251.1_Silent_p.V273V	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	273	Mediates the tyrosine-protein kinase activity.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding	p.V273V(1)		NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				CATCTTCTACGACCCAAGGTG	0.423000													24	105					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281220	152281220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152281220C>T	ENST00000368799.1	-	3	6177	c.6142G>A	c.(6142-6144)Gag>Aag	p.E2048K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2048	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAATGTCCCTCACTGTCACTG	0.562000									Ichthyosis				232	548					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47958661	47958661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47958661G>A	ENST00000426837.2	-	8	794	c.707C>T	c.(706-708)cCc>cTc	p.P236L	MAP4_ENST00000383737.4_Missense_Mutation_p.P219L|MAP4_ENST00000360240.6_Missense_Mutation_p.P219L|MAP4_ENST00000395734.3_Missense_Mutation_p.P219L			P27816	MAP4_HUMAN	microtubule-associated protein 4	219					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TAGCTCTAAGGGAACTAAATT	0.413000													37	109					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43411806	43411806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43411806C>T	ENST00000187910.2	-	4	972	c.907G>A	c.(907-909)Gaa>Aaa	p.E303K	PSG6_ENST00000292125.2_Missense_Mutation_p.E303K|PSG6_ENST00000402603.4_Intron	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				GGTCCTGTTTCATTTCTCGTG	0.493000													105	248					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107956543	107956543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:107956543C>T	ENST00000285311.3	-	1	911	c.206G>A	c.(205-207)gGc>gAc	p.G69D	DKK2_ENST00000513208.1_Intron|DKK2_ENST00000510463.1_Intron	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	69					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CAGGTTTTTGCCCTTCTTACT	0.577000													11	77					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11071021	11071021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11071021C>T	ENST00000287766.4	+	12	1727	c.1306C>T	c.(1306-1308)Ctc>Ttc	p.L436F	SLC6A1_ENST00000536032.1_Missense_Mutation_p.L258F	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	436					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCTGATCGGTCTCTCTAACAT	0.592000													9	43					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070509	9070509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9070509G>A	ENST00000397910.4	-	3	17140	c.16937C>T	c.(16936-16938)tCc>tTc	p.S5646F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5648	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATGTGGAGGAAACAGGAGA	0.517000													12	21					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118456684	118456684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:118456684C>T	ENST00000311085.8	+	9	1032	c.952C>T	c.(952-954)Cgt>Tgt	p.R318C	DMXL1_ENST00000539542.1_Missense_Mutation_p.R318C	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	318										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GAGACATTTTCGTAGAGGTCG	0.398000													12	141					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193080175	193080175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:193080175C>T	ENST00000342358.4	-	5	648	c.531G>A	c.(529-531)gaG>gaA	p.E177E		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	177					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CCTACCTGACCTCTTGCTCTT	0.418000													19	43					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142480031	142480031	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142480031G>A	ENST00000603901.1	+	0	163					NR_001296.3																						CCTCATCAGCGAACAGTGGGT	0.577000													48	140					0	0	1	0	0
HTRA3	94031	broad.mit.edu	37	4	8305930	8305930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8305930G>A	ENST00000307358.2	+	8	1324	c.1120G>A	c.(1120-1122)Gcc>Acc	p.A374T		NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	374	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						TGAGCTGAAGGCCAGCAACCC	0.587000													12	35					0	0	1	0	0
SDR16C5	195814	broad.mit.edu	37	8	57221519	57221519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57221519G>A	ENST00000396721.2	-	3	531	c.401C>T	c.(400-402)tCa>tTa	p.S134L	SDR16C5_ENST00000303749.3_Missense_Mutation_p.S178L|SDR16C5_ENST00000522671.1_Missense_Mutation_p.S178L			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	178					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						TAATCCAGCTGAACTTGAAAT	0.333000													28	51					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230928654	230928654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230928654G>A	ENST00000354537.1	+	16	1854	c.1772G>A	c.(1771-1773)cGg>cAg	p.R591Q	RP11-99J16__A.2_ENST00000452640.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA|CAPN9_ENST00000366666.2_Missense_Mutation_p.R554Q|RP11-99J16__A.2_ENST00000428480.1_RNA|CAPN9_ENST00000271971.2_Missense_Mutation_p.R617Q|CAPN9_ENST00000480004.1_3'UTR	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	617	Domain IV.|EF-hand 2.|EF-hand 3.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TATGAACTACGGACTGCACTG	0.527000													65	119					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554173	135554173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135554173C>T	ENST00000372146.4	+	2	1731	c.1167C>T	c.(1165-1167)agC>agT	p.S389S	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	389					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GTAGTTGCAGCTTAGTAGTGG	0.443000													56	123					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77951244	77951244	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77951244G>A	ENST00000342219.4	-	2	216	c.160C>T	c.(160-162)Cct>Tct	p.P54S	ISM2_ENST00000429906.1_Intron|ISM2_ENST00000493585.1_Missense_Mutation_p.P54S|ISM2_ENST00000393684.3_5'UTR|ISM2_ENST00000412904.1_Missense_Mutation_p.P54S	NM_199296.2	NP_954993.1	Q6H9L7	ISM2_HUMAN	isthmin 2	54						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						AGAGGCCTAGGATCTGGGGAG	0.607000													7	73					0	0	1	0	0
UBE3A	7337	broad.mit.edu	37	15	25585356	25585356	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25585356G>A	ENST00000232165.3	-	12	3030	c.2374C>T	c.(2374-2376)Cat>Tat	p.H792Y	UBE3A_ENST00000397954.2_Missense_Mutation_p.H795Y|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000566215.1_Missense_Mutation_p.H772Y|UBE3A_ENST00000438097.1_Missense_Mutation_p.H772Y|UBE3A_ENST00000428984.2_Missense_Mutation_p.H772Y	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	795	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GTAAATGAATGAACGATTTCC	0.368000													30	86					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	39980049	39980049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:39980049G>A	ENST00000308666.3	-	7	1832	c.1697C>T	c.(1696-1698)tCa>tTa	p.S566L		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	566	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						ATCATCCACTGAATCAGGGTA	0.388000													30	46					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68905294	68905294	+	Silent	SNP	G	G	A	rs114379164	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:68905294G>A	ENST00000262340.5	-	7	728	c.675C>T	c.(673-675)atC>atT	p.I225I		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	225					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						ATTGTACAACGATCTCTGACT	0.363000													27	102					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131859669	131859669	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131859669C>T	ENST00000286355.5	-	11	4595		c.e11+1		ADCY8_ENST00000377928.3_Intron	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TAAATAAATACCTCTGGGTAG	0.423000										HNSCC(32;0.087)			13	21					0	0	1	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78316640	78316640	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78316640A>C	ENST00000409931.3	-	6	1399	c.1328T>G	c.(1327-1329)cTc>cGc	p.L443R	TBC1D2B_ENST00000300584.3_Missense_Mutation_p.L443R			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	443						intracellular	protein binding|Rab GTPase activator activity			breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GGTCTCCATGAGCATTCCCAG	0.602000													27	78					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2820382	2820382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2820382C>T	ENST00000301740.8	+	13	8600	c.8051C>T	c.(8050-8052)tCc>tTc	p.S2684F		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2684	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CCAATAGACTCCCTCAGGGAC	0.652000													3	13					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43771281	43771281	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43771281G>A	ENST00000389420.3	-	32	4881	c.4882C>T	c.(4882-4884)Cga>Tga	p.R1628*		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1628	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GGCCGAAGTCGATGGAGCTTA	0.408000													8	32					0	0	1	0	0
AVPR1A	552	broad.mit.edu	37	12	63541245	63541245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:63541245C>T	ENST00000299178.2	-	2	1256	c.1151G>A	c.(1150-1152)aGa>aAa	p.R384K		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	384					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	AAAAGTCTGTCTTCTGCTCAT	0.403000													23	117					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60904229	60904229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60904229G>A	ENST00000252999.3	-	33	4266	c.4200C>T	c.(4198-4200)ttC>ttT	p.F1400F		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1400	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTGGCTGATGAAGTCATAGG	0.632000													26	71					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13746268	13746268	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:13746268G>C	ENST00000383314.2	+	9	1429	c.1189G>C	c.(1189-1191)Gaa>Caa	p.E397Q	RNMT_ENST00000589866.1_Missense_Mutation_p.E397Q|RNMT_ENST00000592764.1_Missense_Mutation_p.E397Q|RNMT_ENST00000543302.2_Missense_Mutation_p.E397Q|RNMT_ENST00000535051.1_Missense_Mutation_p.E155Q|RNMT_ENST00000262173.3_Missense_Mutation_p.E397Q			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	397					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						AACATTTCTGGAATTCTACGA	0.308000													32	84					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37948651	37948651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37948651C>T	ENST00000377707.3	-	5	1892	c.1327G>A	c.(1327-1329)Gac>Aac	p.D443N	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	443	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		AGGGAGTAGTCATGCTTGCTG	0.627000													6	56					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74635414	74635414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74635414G>A	ENST00000358632.4	-	5	1115	c.420C>T	c.(418-420)taC>taT	p.Y140Y	CYP11A1_ENST00000419019.2_Silent_p.Y140Y|CYP11A1_ENST00000268053.6_Silent_p.Y298Y|CYP11A1_ENST00000541301.1_3'UTR	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	298					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GGATGCCACGGTAATCGTGGT	0.512000													81	82					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85530629	85530629	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85530629C>T	ENST00000295887.5	+	3	716	c.293C>T	c.(292-294)tCg>tTg	p.S98L		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	98					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		ACTATGATCTCGTTGTTTTTC	0.348000													49	103					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209200558	209200558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:209200558C>T	ENST00000264380.4	+	26	4456	c.4298C>T	c.(4297-4299)tCt>tTt	p.S1433F	PIKFYVE_ENST00000474721.1_3'UTR	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1433					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						AGACTTGCATCTTTGAAAACT	0.308000													7	86					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75108826	75108826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75108826C>T	ENST00000309664.5	+	3	528	c.389C>T	c.(388-390)tCg>tTg	p.S130L	LMAN1L_ENST00000379709.3_Missense_Mutation_p.S130L	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	130	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding	p.S130L(1)		NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGGCTGGCTTCGTGGGACGGC	0.667000													94	67					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278255	36278255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36278255C>T	ENST00000007510.4	+	21	2932	c.2788C>T	c.(2788-2790)Ccc>Tcc	p.P930S	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.P794S|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.P769S			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	930					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						TTCCCAATCCCCCTTCCACCG	0.701000													10	53					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241329	126241329	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126241329G>A	ENST00000394329.3	+	1	3776	c.3763G>A	c.(3763-3765)Gaa>Aaa	p.E1255K		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1255	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGGAAATGAAGAAAGACAGTT	0.373000													11	49					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49433990	49433990	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49433990G>A	ENST00000301067.7	-	31	7562	c.7563C>T	c.(7561-7563)tcC>tcT	p.S2521S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCGTCCCAGGGGACCGGACAA	0.672000													5	41					0	0	1	0	0
TNFRSF18	8784	broad.mit.edu	37	1	1139585	1139585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1139585G>A	ENST00000379268.2	-	4	549	c.430C>T	c.(430-432)Cct>Tct	p.P144S	TNFRSF18_ENST00000486728.1_Missense_Mutation_p.P72S|TNFRSF18_ENST00000379265.5_Missense_Mutation_p.P144S|TNFRSF18_ENST00000328596.6_Intron	NM_004195.2|NM_148902.1	NP_004186.1|NP_683700.1	Q9Y5U5	TNR18_HUMAN	tumor necrosis factor receptor superfamily, member 18	144					anti-apoptosis|apoptosis	extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTGTTCCCAGGGAACACAGTG	0.682000													3	15					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24210737	24210737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24210737C>T	ENST00000345044.6	+	3	458	c.190C>T	c.(190-192)Ctg>Ttg	p.L64L	SLC2A11_ENST00000316185.8_Silent_p.L67L|SLC2A11_ENST00000467660.1_3'UTR|AP000350.10_ENST00000433835.3_Silent_p.L29L|SLC2A11_ENST00000398356.2_Silent_p.L71L|SLC2A11_ENST00000405847.1_Silent_p.L64L|SLC2A11_ENST00000403208.3_Silent_p.L64L			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	64						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						TCACCTAGTCCTGCTTATGTG	0.562000													16	94					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172007471	172007471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:172007471C>T	ENST00000358155.4	+	7	1038	c.862C>T	c.(862-864)Cac>Tac	p.H288Y	DNM3_ENST00000367733.2_Missense_Mutation_p.H288Y|DNM3_ENST00000367731.1_Missense_Mutation_p.H288Y|DNM3_ENST00000520906.1_Missense_Mutation_p.H288Y|DNM3_ENST00000355305.5_Missense_Mutation_p.H288Y	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	288					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						ACTTACCAACCACATTCGGGA	0.378000													17	53					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8819105	8819105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:8819105C>T	ENST00000359865.3	+	13	3146	c.3004C>T	c.(3004-3006)Ccg>Tcg	p.P1002S	SOGA2_ENST00000306285.7_Missense_Mutation_p.P327S|SOGA2_ENST00000306329.11_Missense_Mutation_p.P1321S|SOGA2_ENST00000400050.3_Missense_Mutation_p.P961S|SOGA2_ENST00000518815.1_Missense_Mutation_p.P327S|SOGA2_ENST00000517570.1_Missense_Mutation_p.P961S	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1312																	TGACTCCATCCCGTTTGAAGA	0.597000													25	66					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141325255	141325255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141325255C>T	ENST00000231484.3	-	4	4456	c.3246G>A	c.(3244-3246)gaG>gaA	p.E1082E		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	1082					neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTTGGCTCCTCCGTGGCTG	0.632000													25	77					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57257945	57257945	+	Missense_Mutation	SNP	C	C	T	rs147103664		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57257945C>T	ENST00000343433.6	-	2	621	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	181								p.E181K(1)		NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TTCCTGGGTTCCTCTGGAGTA	0.488000													10	126					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160961164	160961164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160961164C>T	ENST00000447678.1	-	37	5766	c.5646G>A	c.(5644-5646)gtG>gtA	p.V1882V	LPA_ENST00000484276.1_5'UTR|LPA_ENST00000316300.5_Silent_p.V1882V	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4390	Kringle 17.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATTCGAGGTTCACTTCTTGGT	0.473000													39	43					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31342525	31342525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31342525C>T	ENST00000544665.3	+	29	3390	c.3319C>T	c.(3319-3321)Ctg>Ttg	p.L1107L	ITGAM_ENST00000287497.8_Silent_p.L1106L	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1106					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CCCCAACCCCCTGCCGCTCAT	0.677000													23	42					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4944978	4944978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4944978G>A	ENST00000321961.2	-	1	659	c.592C>T	c.(592-594)Cac>Tac	p.H198Y	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATAGATGTGATTGACAATG	0.532000													7	94					0	0	1	0	0
BRD7	29117	broad.mit.edu	37	16	50388763	50388763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50388763G>A	ENST00000394688.3	-	3	488	c.329C>T	c.(328-330)cCt>cTt	p.P110L	BRD7_ENST00000401491.3_5'UTR|BRD7_ENST00000394689.2_Missense_Mutation_p.P110L			Q9NPI1	BRD7_HUMAN	bromodomain containing 7	110					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				TAATCTCACAGGGGCGTGACA	0.443000													28	116					0	0	1	0	0
NOX1	27035	broad.mit.edu	37	X	100125744	100125744	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:100125744C>T	ENST00000372966.3	-	2	310	c.105G>A	c.(103-105)aaG>aaA	p.K35K	NOX1_ENST00000372960.4_Silent_p.K35K|NOX1_ENST00000372964.1_Silent_p.K35K|NOX1_ENST00000217885.5_Silent_p.K35K	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	35					angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						ATTTGTCGGCCTTCTCATATT	0.378000													38	42					0	0	1	0	0
GJB2	2706	broad.mit.edu	37	13	20763336	20763336	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:20763336C>T	ENST00000382844.1	-	1	583	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K	GJB2_ENST00000382848.4_Missense_Mutation_p.E129K			P29033	CXB2_HUMAN	gap junction protein, beta 2, 26kDa	129			E -> K (in DFNB1A).		cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane				breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		AGGGAGCCTTCGATGCGGACC	0.507000									Keratitis, Ichthyosis and Deafness syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	68					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177041212	177041212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:177041212G>A	ENST00000393643.2	+	4	754	c.502G>A	c.(502-504)Ggt>Agt	p.G168S	WDR17_ENST00000508596.1_Missense_Mutation_p.G168S|WDR17_ENST00000280190.4_Missense_Mutation_p.G192S|WDR17_ENST00000507824.2_Missense_Mutation_p.G192S	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	192										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		AGTTGTGTTTGGTCATATTGA	0.323000													29	153					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17578719	17578719	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17578719C>T	ENST00000319363.6	+	3	329	c.196C>T	c.(196-198)Cga>Tga	p.R66*	IL17RA_ENST00000477874.1_3'UTR	NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	66					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity	p.R66*(1)		endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		GATTCACCCTCGAAACCTGAC	0.577000													21	48					0	0	1	0	0
ARHGAP4	393	broad.mit.edu	37	X	153174589	153174589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153174589G>A	ENST00000370028.3	-	22	2719	c.2662C>T	c.(2662-2664)Ccc>Tcc	p.P888S	ARHGAP4_ENST00000350060.5_Missense_Mutation_p.P848S|ARHGAP4_ENST00000393721.1_Missense_Mutation_p.P670S|ARHGAP4_ENST00000537206.1_Missense_Mutation_p.P825S|ARHGAP4_ENST00000370016.1_Missense_Mutation_p.P827S	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	848					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGTCCAGAGGGTCCCATGGCC	0.642000													19	9					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10713796	10713796	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10713796G>A	ENST00000377022.3	-	11	2635	c.2318C>T	c.(2317-2319)tCg>tTg	p.S773L	RP4-734G22.3_ENST00000606802.1_RNA|CASZ1_ENST00000344008.5_Missense_Mutation_p.S773L	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	773					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CAGCAGCCCCGAGATCTTGCT	0.701000													19	39					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86394822	86394822	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86394822G>A	ENST00000361669.2	+	2	1460	c.361G>A	c.(361-363)Gat>Aat	p.D121N	GRM3_ENST00000394720.2_Missense_Mutation_p.D119N|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Missense_Mutation_p.D121N|GRM3_ENST00000536043.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	121					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GACAAAAGTGGATGAAGCTGA	0.438000													46	146					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24671403	24671403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24671403G>A	ENST00000361548.4	+	12	1666	c.1436G>A	c.(1435-1437)gGa>gAa	p.G479E	GRHL3_ENST00000350501.5_Missense_Mutation_p.G479E|GRHL3_ENST00000356046.2_Missense_Mutation_p.G433E|GRHL3_ENST00000342072.4_Missense_Mutation_p.G386E|GRHL3_ENST00000236255.4_Missense_Mutation_p.G484E	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	479					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CCCTCGGCAGGACCCAGCAGC	0.597000													15	52					0	0	1	0	0
GGT7	2686	broad.mit.edu	37	20	33433180	33433180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33433180G>A	ENST00000336431.5	-	15	1984	c.1940C>T	c.(1939-1941)gCt>gTt	p.A647V	GGT7_ENST00000469018.1_5'UTR	NM_178026.2	NP_821158.2	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	647					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			NS(2)|breast(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	20						GTCCTTAACAGCGATGATGAA	0.577000													21	43					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509747	106509747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:106509747G>A	ENST00000359195.3	+	2	2051	c.1741G>A	c.(1741-1743)Gaa>Aaa	p.E581K	PIK3CG_ENST00000440650.2_Missense_Mutation_p.E581K|PIK3CG_ENST00000496166.1_Missense_Mutation_p.E581K	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	581					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						TTTTAGATACGAAAGCCTTAA	0.453000													39	71					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54606840	54606840	+	Missense_Mutation	SNP	C	C	T	rs141787724		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54606840C>T	ENST00000371330.1	-	3	1541	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K		NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	232	CUB 2.					extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						ACCTGCAGTTCGTGGCCCAGA	0.637000													18	61					0	0	1	0	0
TNP2	7142	broad.mit.edu	37	16	11363045	11363045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11363045G>A	ENST00000312693.3	-	1	144	c.75C>T	c.(73-75)acC>acT	p.T25T	RMI2_ENST00000572173.1_Intron	NM_005425.4	NP_005416.1	Q05952	STP2_HUMAN	transition protein 2 (during histone to protamine replacement)	25					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding	p.0?(1)		large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6						GGCGGGTGCAGGTGCGGCTTT	0.632000													38	154					0	0	1	0	0
OR51I2	390064	broad.mit.edu	37	11	5474840	5474840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5474840G>A	ENST00000341449.2	+	1	203	c.122G>A	c.(121-123)gGa>gAa	p.G41E	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCCTTGGGGGAAATACAGTG	0.572000													28	52					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157805787	157805787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157805787C>T	ENST00000368174.4	-	3	310	c.214G>A	c.(214-216)Gga>Aga	p.G72R	CD5L_ENST00000484609.1_5'UTR	NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	72	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTAGGGGTTCCGCTGGCAGCT	0.542000													29	247					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	123988176	123988176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123988176C>T	ENST00000392744.4	+	2	1334	c.6C>T	c.(4-6)tcC>tcT	p.S2S	VWA5A_ENST00000361352.5_Intron|VWA5A_ENST00000360334.4_Intron|VWA5A_ENST00000392748.1_Intron|VWA5A_ENST00000449321.1_Intron|VWA5A_ENST00000456829.2_Intron			O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	0	VIT.									autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						CCAACATGTCCTCTGTTTGTG	0.433000													6	58					0	0	1	0	0
FAM83A	84985	broad.mit.edu	37	8	124219654	124219654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124219654C>T	ENST00000518448.1	+	5	3045	c.1031C>T	c.(1030-1032)cCc>cTc	p.P344L	FAM83A_ENST00000318462.6_Missense_Mutation_p.P344L|FAM83A_ENST00000276699.6_Missense_Mutation_p.P344L|FAM83A_ENST00000546351.1_Missense_Mutation_p.P288L|FAM83A_ENST00000536633.1_Missense_Mutation_p.P344L|FAM83A_ENST00000522648.1_Missense_Mutation_p.P288L			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	344	Ser-rich.									breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GGCAGCCACCCCGGTACCCGA	0.726000													9	22					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416761	29416761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29416761G>A	ENST00000389048.3	-	29	5098	c.4192C>T	c.(4192-4194)Ccg>Tcg	p.P1398S	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1398					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TATTCTATCGGCAAAGCGGTG	0.468000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				5	52					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886187	9886187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:9886187G>A	ENST00000306084.6	+	1	215	c.16G>A	c.(16-18)Gaa>Aaa	p.E6K	TXNDC2_ENST00000357775.4_Intron|TXNDC2_ENST00000536353.2_Intron|TXNDC2_ENST00000584255.1_Intron|TXNDC2_ENST00000426718.3_Missense_Mutation_p.E6K	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	6					cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						TGTAGACAAGGAACTAGGAAT	0.428000													6	28					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093446	30093446	+	RNA	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30093446T>G	ENST00000567636.1	+	0	1821					NR_003558.1																						CCACCCGGCTTGATTCAGCGA	0.542000													91	154					0	0	1	0	0
AP1M2	10053	broad.mit.edu	37	19	10685646	10685646	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10685646C>T	ENST00000590923.1	-	10	1196	c.1113G>A	c.(1111-1113)gaG>gaA	p.E371E	AP1M2_ENST00000250244.6_Silent_p.E369E			Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	369	MHD.				cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			endometrium(4)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	9			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			GGCCCTCCACCTCTTCCTTTT	0.617000													4	16					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115341822	115341822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115341822C>T	ENST00000351270.3	+	9	1122	c.1026C>T	c.(1024-1026)ccC>ccT	p.P342P	HABP2_ENST00000542051.1_Silent_p.P316P|HABP2_ENST00000541666.1_Intron	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	342	Peptidase S1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		TCTCCATGCCCCAGGGCCACT	0.642000													14	32					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49654453	49654453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49654453C>T	ENST00000249601.4	-	10	2374	c.2078G>A	c.(2077-2079)gGt>gAt	p.G693D	ARHGAP22_ENST00000417912.2_Missense_Mutation_p.G709D|ARHGAP22_ENST00000477708.2_Missense_Mutation_p.G526D|ARHGAP22_ENST00000374170.1_Missense_Mutation_p.G534D|ARHGAP22_ENST00000417247.2_Missense_Mutation_p.G603D|ARHGAP22_ENST00000374172.1_Missense_Mutation_p.G584D|ARHGAP22_ENST00000435790.2_Missense_Mutation_p.G699D	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	693					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GGCCCTGGCACCTTTTGCCCC	0.542000													20	85					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33954784	33954784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33954784G>A	ENST00000389232.4	+	35	5123	c.5053G>A	c.(5053-5055)Gag>Aag	p.E1685K	RYR3_ENST00000415757.3_Missense_Mutation_p.E1685K	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1685	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCAGAGCCCCGAGATTCCCTT	0.592000													33	85					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19566052	19566052	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:19566052C>T	ENST00000409832.3	+	6	1148	c.1096C>T	c.(1096-1098)Cta>Tta	p.L366L	CTD-2311B13.5_ENST00000548748.1_lincRNA	NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	366										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						AAAACAGATGCTAAAAGTCTC	0.308000													12	161					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140265500	140265500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140265500G>A	ENST00000458420.3	+	10	1841	c.1651G>A	c.(1651-1653)Gaa>Aaa	p.E551K		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	551					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						TAATTCCTTGGAAAGCCTTGG	0.557000										HNSCC(16;0.037)			11	21					0	0	1	0	0
TFCP2	7024	broad.mit.edu	37	12	51504689	51504689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51504689G>A	ENST00000307660.4	-	5	1255	c.535C>T	c.(535-537)Cct>Tct	p.P179S	TFCP2_ENST00000549867.1_Missense_Mutation_p.P179S|TFCP2_ENST00000257915.5_Missense_Mutation_p.P179S|TFCP2_ENST00000548115.1_Missense_Mutation_p.P179S	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	179	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						CTCTTTGCAGGGTCCCACAGG	0.403000													41	138					0	0	1	0	0
RPUSD4	84881	broad.mit.edu	37	11	126074205	126074205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:126074205C>T	ENST00000298317.4	-	6	868	c.815G>A	c.(814-816)cGa>cAa	p.R272Q	RPUSD4_ENST00000533628.1_Missense_Mutation_p.R241Q	NM_032795.2	NP_116184.2	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	272					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		CAAGTGAACTCGAAGCTGATG	0.413000													15	65					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13214675	13214675	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:13214675C>T	ENST00000378694.1	+	4	577	c.502C>T	c.(502-504)Cag>Tag	p.Q168*	MCM10_ENST00000378714.3_Nonsense_Mutation_p.Q168*|MCM10_ENST00000484800.2_Nonsense_Mutation_p.Q169*			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	169					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						TCAGAGAATTCAGGAGTCAAC	0.468000													8	108					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49687651	49687651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49687651G>A	ENST00000374172.1	-	3	358	c.104C>T	c.(103-105)cCt>cTt	p.P35L	ARHGAP22_ENST00000417912.2_Missense_Mutation_p.P160L|ARHGAP22_ENST00000249601.4_Intron|ARHGAP22_ENST00000374170.1_Intron|ARHGAP22_ENST00000417247.2_Intron|ARHGAP22_ENST00000435790.2_Intron			Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	151					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GGGTTCTAGAGGGTGGGCATG	0.637000													8	19					0	0	1	0	0
DHRS3	9249	broad.mit.edu	37	1	12638970	12638970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12638970G>A	ENST00000376223.2	-	4	857	c.474C>T	c.(472-474)ttC>ttT	p.F158F		NM_004753.4	NP_004744.2	O75911	DHRS3_HUMAN	dehydrogenase/reductase (SDR family) member 3	158					retinol metabolic process|visual perception	integral to membrane	electron carrier activity|NADP-retinol dehydrogenase activity|nucleotide binding			cervix(1)|large_intestine(4)|lung(2)|prostate(1)|skin(1)	9	Ovarian(185;0.249)	Lung NSC(185;4.11e-05)|all_lung(284;4.58e-05)|Renal(390;0.000147)|Colorectal(325;0.000585)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;9.25e-07)|COAD - Colon adenocarcinoma(227;0.000326)|BRCA - Breast invasive adenocarcinoma(304;0.000344)|Kidney(185;0.00235)|KIRC - Kidney renal clear cell carcinoma(229;0.00656)|STAD - Stomach adenocarcinoma(313;0.00798)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	TACGTGGCAGGAAGGCCTTGG	0.622000													7	34					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68398989	68398989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68398989C>T	ENST00000219334.5	-	4	1933	c.1330G>A	c.(1330-1332)Gtg>Atg	p.V444M	SMPD3_ENST00000566009.1_5'UTR|SMPD3_ENST00000563226.1_Missense_Mutation_p.V444M|SMPD3_ENST00000568373.1_Missense_Mutation_p.V444M	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	444					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	GTGCTTCCCACCTGCACCTGG	0.617000													12	35					0	0	1	0	0
NPFFR1	64106	broad.mit.edu	37	10	72026113	72026113	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72026113G>A	ENST00000277942.5	-	2	49	c.42C>T	c.(40-42)ccC>ccT	p.P14P		NM_022146.4	NP_071429.1	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1	14						integral to membrane|plasma membrane	neuropeptide receptor activity			endometrium(2)|lung(1)	3						TCTGACTTAGGGGCCAACTGC	0.537000													8	15					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97192238	97192238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97192238G>A	ENST00000371247.2	-	6	457	c.268C>T	c.(268-270)Cct>Tct	p.P90S	SORBS1_ENST00000277982.5_Missense_Mutation_p.P90S|SORBS1_ENST00000306402.6_Missense_Mutation_p.P90S|SORBS1_ENST00000361941.3_Missense_Mutation_p.P90S|SORBS1_ENST00000607232.1_Missense_Mutation_p.P58S|SORBS1_ENST00000371241.1_Missense_Mutation_p.P58S|SORBS1_ENST00000347291.4_Missense_Mutation_p.P90S|SORBS1_ENST00000354106.3_Missense_Mutation_p.P90S|SORBS1_ENST00000371245.3_Missense_Mutation_p.P90S|SORBS1_ENST00000371246.2_Missense_Mutation_p.P90S|SORBS1_ENST00000371227.4_Missense_Mutation_p.P90S|SORBS1_ENST00000371239.1_Missense_Mutation_p.P58S|SORBS1_ENST00000353505.5_Missense_Mutation_p.P90S|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000371249.2_Missense_Mutation_p.P58S|SORBS1_ENST00000393949.1_Missense_Mutation_p.P90S			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	90					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GTTTCCTGAGGGCTCGCAGGG	0.572000													26	119					0	0	1	0	0
SYT7	9066	broad.mit.edu	37	11	61290624	61290624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61290624C>T	ENST00000263846.4	-	8	1357	c.1030G>A	c.(1030-1032)Gag>Aag	p.E344K	SYT7_ENST00000535826.1_Missense_Mutation_p.E463K|SYT7_ENST00000542836.1_Missense_Mutation_p.E388K|SYT7_ENST00000542670.1_Missense_Mutation_p.E552K|SYT7_ENST00000539008.1_Missense_Mutation_p.E627K|SYT7_ENST00000540677.1_Missense_Mutation_p.E419K	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	344	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CTCAGCTTCTCCGTGGGGATA	0.547000													30	94					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18762339	18762339	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18762339C>T	ENST00000396170.1	-	8	1894	c.629_splice	c.e8-1	p.R210_splice	PTPN5_ENST00000396171.4_Splice_Site_p.R242_splice|PTPN5_ENST00000396167.2_Splice_Site_p.R210_splice|PTPN5_ENST00000358540.2_Splice_Site_p.R242_splice|PTPN5_ENST00000477854.1_Splice_Site_p.R46_splice|PTPN5_ENST00000496201.2_5'UTR|PTPN5_ENST00000396168.1_Splice_Site_p.R218_splice	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	242						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						TGGAACCCCTCCTGGAAGGAC	0.627000													9	30					0	0	1	0	0
HERC3	8916	broad.mit.edu	37	4	89574082	89574082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89574082C>T	ENST00000402738.1	+	6	765	c.526C>T	c.(526-528)Ccc>Tcc	p.P176S	HERC3_ENST00000407637.1_Missense_Mutation_p.P176S|HERC3_ENST00000264345.3_Missense_Mutation_p.P176S	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	176					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		GAAGGAGTTCCCCTCCCAAGC	0.562000													15	36					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323749	44323749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:44323749C>T	ENST00000354250.2	+	3	696	c.627C>T	c.(625-627)acC>acT	p.T209T	NDUFV3_ENST00000340344.3_Intron|NDUFV3_ENST00000460259.1_3'UTR	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	40					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	AAGAGAAAACCTTGCTGCAGA	0.522000													14	119					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6953077	6953077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6953077G>A	ENST00000229264.3	+	9	1039	c.634G>A	c.(634-636)Gat>Aat	p.D212N	GNB3_ENST00000435982.2_Missense_Mutation_p.D211N	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	212					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						CAAGCTCTGGGATGTGCGAGA	0.577000													27	77					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63059015	63059015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63059015G>A	ENST00000332793.6	+	2	408	c.406G>A	c.(406-408)Gac>Aac	p.D136N	SLC22A10_ENST00000526800.1_Missense_Mutation_p.D84N|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_5'UTR	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	136						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTTCCAGTGGGACCTGGTATG	0.463000													16	45					0	0	1	0	0
PITX1	5307	broad.mit.edu	37	5	134364788	134364788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134364788G>A	ENST00000265340.7	-	3	1042	c.626C>T	c.(625-627)tCg>tTg	p.S209L	PITX1_ENST00000506438.1_Missense_Mutation_p.S209L	NM_002653.4	NP_002644.4	P78337	PITX1_HUMAN	paired-like homeodomain 1	209	Interacts with PIT-1 (By similarity).					nucleolus	sequence-specific DNA binding			central_nervous_system(1)|cervix(3)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		GGACTGCGACGACAGCGGGCT	0.652000													16	80					0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77457903	77457903	+	Missense_Mutation	SNP	G	G	A	rs138457062	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:77457903G>A	ENST00000299543.7	+	4	683	c.536G>A	c.(535-537)cGa>cAa	p.R179Q	CTDP1_ENST00000075430.7_Missense_Mutation_p.R179Q	NM_001202504.1|NM_004715.4	NP_001189433.1|NP_004706.3	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	179	FCP1 homology.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CGACTGCACCGAAACCGGAAG	0.473000													20	42					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156834207	156834207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156834207G>A	ENST00000368196.3	+	2	394	c.274G>A	c.(274-276)Gag>Aag	p.E92K	NTRK1_ENST00000524377.1_Missense_Mutation_p.E92K|NTRK1_ENST00000358660.3_Missense_Mutation_p.E92K|NTRK1_ENST00000392302.2_Missense_Mutation_p.E62K	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	92					activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GGGCCTGGGGGAGCTGAGAAA	0.637000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			12	29					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27681043	27681043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27681043G>A	ENST00000260570.3	-	27	3028	c.2925C>T	c.(2923-2925)atC>atT	p.I975I		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	975					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GGGCCTGAGTGATGTATAGCA	0.552000													11	121					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559734	140559734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140559734C>T	ENST00000239444.2	+	1	2364	c.2119C>T	c.(2119-2121)Ctc>Ttc	p.L707F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		707					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTCTCGGTGCTCCTGTTCGT	0.672000													46	200					0	0	1	0	0
KIAA0825	285600	broad.mit.edu	37	5	93856513	93856513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:93856513G>A	ENST00000513200.3	-	4	482	c.410C>T	c.(409-411)tCt>tTt	p.S137F	KIAA0825_ENST00000427991.2_Missense_Mutation_p.S137F|KIAA0825_ENST00000329378.7_Missense_Mutation_p.S137F|KIAA0825_ENST00000312498.7_Missense_Mutation_p.S137F	NM_001145678.1	NP_001139150.1	Q8IV33	K0825_HUMAN	KIAA0825	137										breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|pancreas(1)|prostate(1)|skin(1)	13						GAAATGGAAAGATGTTCCACT	0.413000													13	42					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233655986	233655986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233655986C>T	ENST00000373566.3	+	13	1375	c.1178C>T	c.(1177-1179)cCc>cTc	p.P393L	GIGYF2_ENST00000409480.1_Missense_Mutation_p.P393L|GIGYF2_ENST00000409547.1_Missense_Mutation_p.P371L|GIGYF2_ENST00000452341.2_Missense_Mutation_p.P202L|GIGYF2_ENST00000409451.3_Missense_Mutation_p.P392L|GIGYF2_ENST00000409196.3_Missense_Mutation_p.P365L|GIGYF2_ENST00000373563.4_Missense_Mutation_p.P371L			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	371					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GAGGAAACTCCCCAGACCTCA	0.438000													36	78					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38424437	38424437	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38424437G>A	ENST00000356264.2	-	21	2285	c.2070C>T	c.(2068-2070)ttC>ttT	p.F690F	AMPH_ENST00000428293.2_Silent_p.F648F|AMPH_ENST00000325590.5_Silent_p.F648F	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	690	SH3.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						AGCGTCGGGTGAAGTTCTCTG	0.458000													29	101					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169747	57169747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57169747G>A	ENST00000371244.4	+	7	958	c.892G>A	c.(892-894)Gaa>Aaa	p.E298K		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	298					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						AGAAGTGTGTGAAAAATTTGA	0.383000													77	179					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52799986	52799986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52799986G>A	ENST00000257974.2	-	1	153	c.76C>T	c.(76-78)Cgg>Tgg	p.R26W		NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	26	Head.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		GTGACCATCCGGGGCATGACA	0.622000													4	32					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56233058	56233058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56233058C>T	ENST00000268912.5	+	1	565	c.544C>T	c.(544-546)Ccc>Tcc	p.P182S		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						CTGTGATGTTCCCCAAGTACT	0.517000													46	113					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10379965	10379965	+	Silent	SNP	C	C	T	rs141820572		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10379965C>T	ENST00000397077.1	-	21	3755	c.3180G>A	c.(3178-3180)ccG>ccA	p.P1060P	ATP2B2_ENST00000383800.4_Silent_p.P1060P|ATP2B2_ENST00000360273.2_Silent_p.P1105P|ATP2B2_ENST00000352432.4_Silent_p.P1105P|ATP2B2_ENST00000343816.4_Silent_p.P1091P			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	1105					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GCTCCTCCTCCGGGATCTCCT	0.632000													18	98					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367098	142367098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142367098C>T	ENST00000377741.3	-	2	1016	c.926G>A	c.(925-927)cGa>cAa	p.R309Q		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	309						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			GAAGAGGCCTCGGACGGTGGC	0.637000													8	53					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148951279	148951279	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148951279A>G	ENST00000335870.2	+	5	1389	c.1261A>G	c.(1261-1263)Agg>Ggg	p.R421G		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			CATCCCTTGGAGGAAAAGCCG	0.622000													15	33					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69472489	69472489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69472489C>T	ENST00000303714.4	+	18	1889	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	523	Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						ccactgccctcccccgccccc	0.701000									Familial Infantile Hemangioma				4	7					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369377	56369377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56369377C>T	ENST00000301295.6	+	3	1040	c.618C>T	c.(616-618)tcC>tcT	p.S206S	NLRP4_ENST00000587891.1_Silent_p.S131S|NLRP4_ENST00000346986.5_Silent_p.S206S	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	206	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ACTTGATTTCCAGAGAGTGGC	0.532000													12	137					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15197632	15197632	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:15197632G>A	ENST00000379554.3	+	3	589	c.543_splice	c.e3+1	p.E181_splice	INSC_ENST00000528567.1_Splice_Site_p.E134_splice|INSC_ENST00000525218.1_Splice_Site_p.E134_splice|INSC_ENST00000424273.1_Splice_Site_p.E134_splice|INSC_ENST00000379556.3_Splice_Site_p.E134_splice|INSC_ENST00000530161.1_Splice_Site_p.E134_splice	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	181					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						AAATGGGCGAGGTCAGCTGCC	0.557000													3	1					0	0	1	0	0
C5orf46	389336	broad.mit.edu	37	5	147281256	147281256	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147281256G>A	ENST00000515291.1	-	2	187	c.151C>T	c.(151-153)Ctc>Ttc	p.L51F	C5orf46_ENST00000510432.1_5'UTR|C5orf46_ENST00000318315.4_Missense_Mutation_p.L51F			Q6UWT4	CE046_HUMAN	chromosome 5 open reading frame 46	51						extracellular region				NS(1)|lung(1)|prostate(1)	3						GTGCCCAGGAGGCTTAGGAAT	0.493000													10	58					0	0	1	0	0
PRRX1	5396	broad.mit.edu	37	1	170688909	170688909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:170688909G>A	ENST00000239461.6	+	2	597	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	PRRX1_ENST00000497230.2_Missense_Mutation_p.R95Q|PRRX1_ENST00000367760.3_Missense_Mutation_p.R95Q	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	95						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGAAAGCAGCGAAGGAATAGG	0.458000													9	29					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212798992	212798992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:212798992C>T	ENST00000294829.3	+	1	1204	c.773C>T	c.(772-774)tCc>tTc	p.S258F	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	258										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CTCAATGCATCCATCCCCAAA	0.552000													53	125					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29650615	29650615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:29650615C>T	ENST00000318184.5	-	1	4	c.5G>A	c.(4-6)gGc>gAc	p.G2D		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	2					proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GGCCAGCAGGCCCATAGCCTC	0.652000													9	54					0	0	1	0	0
OAT	4942	broad.mit.edu	37	10	126092381	126092381	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:126092381A>G	ENST00000368845.5	-	6	849	c.757T>C	c.(757-759)Tgc>Cgc	p.C253R	OAT_ENST00000539214.1_Missense_Mutation_p.C115R|OAT_ENST00000467675.1_5'UTR	NM_000274.3	NP_000265.1	P04181	OAT_HUMAN	ornithine aminotransferase	253					cellular amino acid biosynthetic process|visual perception	mitochondrial matrix	ornithine-oxo-acid transaminase activity|protein binding|pyridoxal phosphate binding			endometrium(2)|large_intestine(1)|lung(2)	5		all_lung(145;0.0271)|Lung NSC(174;0.0436)|Colorectal(57;0.102)|all_neural(114;0.116)			L-Ornithine(DB00129)|Pyridoxal Phosphate(DB00114)	TGCCTGGTGCAGAGCTCTCGC	0.517000											OREG0020605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	38					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831698	61831698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61831698C>T	ENST00000280772.1	-	37	9132	c.8941G>A	c.(8941-8943)Gaa>Aaa	p.E2981K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2981					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCCGACTGTTCACAAAAACCA	0.438000													28	61					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124761637	124761637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124761637C>T	ENST00000306534.3	-	11	2094	c.1609G>A	c.(1609-1611)Gac>Aac	p.D537N	ROBO4_ENST00000533054.1_Missense_Mutation_p.D392N|RP11-664I21.6_ENST00000524433.1_Intron	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	537					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CTGCTCAGGTCCCGAGAGCCA	0.647000													16	32					0	0	1	0	0
IGHV3-53	28420	broad.mit.edu	37	14	107048762	107048762	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107048762G>A	ENST00000390627.2	-	0	478																											TGGAGATGGTGAATCGGCCCT	0.542000													52	393					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130162345	130162345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130162345G>A	ENST00000265379.6	+	36	7007	c.6513G>A	c.(6511-6513)ccG>ccA	p.P2171P	COL6A5_ENST00000432398.2_Silent_p.P2171P			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2171	Nonhelical region.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						ACCCACCACCGATGCTTGAGG	0.373000													22	52					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80633209	80633209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80633209G>A	ENST00000458043.2	+	10	1021	c.1015G>A	c.(1015-1017)Gat>Aat	p.D339N	OTOGL_ENST00000547103.1_Missense_Mutation_p.D339N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CTGTGTTAATGATCTTTGCAA	0.353000													23	73					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4808358	4808358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4808358G>A	ENST00000354582.6	+	44	5994	c.5644G>A	c.(5644-5646)Gat>Aat	p.D1882N	ITPR1_ENST00000456211.2_Missense_Mutation_p.D1834N|ITPR1_ENST00000443694.2_Missense_Mutation_p.D1882N|ITPR1_ENST00000423119.2_Missense_Mutation_p.D1849N|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.D1849N|ITPR1_ENST00000302640.8_Missense_Mutation_p.D1882N			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1897					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AAAGAAAGACGATGAGGTAGA	0.438000													21	37					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168180991	168180991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168180991G>A	ENST00000519560.1	-	17	2126	c.1707C>T	c.(1705-1707)atC>atT	p.I569I	SLIT3_ENST00000332966.8_Silent_p.I569I|SLIT3_ENST00000404867.3_Silent_p.I569I	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	569					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCACCTCCTTGATCTTATTGT	0.547000													8	11					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62582306	62582306	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62582306G>A	ENST00000371158.2	+	36	4872	c.4758G>A	c.(4756-4758)gaG>gaA	p.E1586E	INADL_ENST00000543708.1_Silent_p.E400E	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1586	PDZ 9.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TGAATGGGGAGGACATGAGAA	0.512000													10	60					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87145863	87145863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87145863G>A	ENST00000265724.3	-	25	3463	c.3046C>T	c.(3046-3048)Cct>Tct	p.P1016S	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Missense_Mutation_p.P952S	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1016					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCAATCAAAGGGGTTTTTTCA	0.448000													31	107					0	0	1	0	0
NPS	594857	broad.mit.edu	37	10	129347818	129347818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129347818C>T	ENST00000398023.1	+	2	94	c.74C>T	c.(73-75)cCa>cTa	p.P25L		NM_001030013.1	NP_001025184.1	P0C0P6	NPS_HUMAN	neuropeptide S	25					neuropeptide signaling pathway	extracellular region				haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						TGGTGTTATCCAGTTCCATCT	0.343000													22	66					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62293078	62293078	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62293078A>G	ENST00000378024.4	-	5	9085	c.8811T>C	c.(8809-8811)gtT>gtC	p.V2937V	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2937					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTTCAATGTTAACATCAGGGC	0.517000													117	243					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45958907	45958907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45958907C>T	ENST00000402984.3	+	16	2030	c.1927C>T	c.(1927-1929)Cgc>Tgc	p.R643C	FBLN1_ENST00000348697.2_Intron|FBLN1_ENST00000327858.6_Intron|FBLN1_ENST00000442170.2_Intron|FBLN1_ENST00000262722.7_Missense_Mutation_p.R605C			P23142	FBLN1_HUMAN	fibulin 1	618					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GGTGGTTTTCCGCATGGGCCC	0.617000													67	172					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367863	107367863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107367863C>T	ENST00000542196.1	-	1	88	c.46G>A	c.(46-48)Gga>Aga	p.G16R		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CCAGAAAGTCCCTTCAGAAAA	0.368000													16	77					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84796646	84796646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84796646C>T	ENST00000219473.7	+	9	1719	c.1606C>T	c.(1606-1608)Cat>Tat	p.H536Y	USP10_ENST00000570191.1_Missense_Mutation_p.H540Y	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	536					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						AAATGGACTTCATGAGGAAAT	0.408000													38	137					0	0	1	0	0
AGBL4	84871	broad.mit.edu	37	1	49052746	49052746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:49052746G>A	ENST00000371839.1	-	11	1313	c.1197C>T	c.(1195-1197)acC>acT	p.T399T	AGBL4_ENST00000334103.7_Silent_p.T132T	NM_032785.3	NP_116174.3	Q5VU57	CBPC6_HUMAN	ATP/GTP binding protein-like 4	399					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15				Colorectal(2;0.00349)|COAD - Colon adenocarcinoma(2;0.0037)		AGACCTCTAGGGTGTAGCAAT	0.562000													4	2					0	0	1	0	0
AMPD2	271	broad.mit.edu	37	1	110163726	110163726	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110163726T>C	ENST00000256578.3	+	1	451	c.91T>C	c.(91-93)Ttg>Ctg	p.L31L	AMPD2_ENST00000526301.1_Intron|AMPD2_ENST00000358729.4_5'UTR|AMPD2_ENST00000528667.1_Silent_p.L31L|AMPD2_ENST00000342115.4_Intron	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	31					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		GAGGAAGGGGTTGGATGTGGC	0.672000													4	16					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602718	96602718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96602718C>T	ENST00000371321.3	+	7	1168	c.1086C>T	c.(1084-1086)atC>atT	p.I362I	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	362					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TCGACCTCATCCCCACCAGCC	0.537000													44	139					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56435862	56435862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:56435862C>T	ENST00000327381.5	+	3	1129	c.1029C>T	c.(1027-1029)ctC>ctT	p.L343L		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	343						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			CAGCTTCCCTCGTGTCCCTGG	0.572000													12	16					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074292	106074292	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106074292G>A	ENST00000278071.2	-	3	1970	c.1518C>T	c.(1516-1518)ttC>ttT	p.F506F	ITPRIP_ENST00000358187.2_Silent_p.F506F|ITPRIP_ENST00000337478.1_Silent_p.F506F	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	506						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						GCTGCAGGACGAAGGGCCGGA	0.587000													24	89					0	0	1	0	0
DEFB118	117285	broad.mit.edu	37	20	29960755	29960755	+	Nonsense_Mutation	SNP	C	C	T	rs34328728		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:29960755C>T	ENST00000253381.2	+	2	187	c.154C>T	c.(154-156)Cga>Tga	p.R52*		NM_054112.2	NP_473453.1	Q96PH6	DB118_HUMAN	defensin, beta 118	52					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CAAAAATCTTCGAGCTTGCTG	0.438000													40	80					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925636	27925636	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:27925636C>T	ENST00000244623.1	+	1	618	c.618C>T	c.(616-618)ttC>ttT	p.F206F		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GTGAGCTCTTCCATCTAATAC	0.423000													63	206					0	0	1	0	0
FOXR1	283150	broad.mit.edu	37	11	118850327	118850327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118850327G>A	ENST00000317011.3	+	4	785	c.560G>A	c.(559-561)aGa>aAa	p.R187K		NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1	187					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CTGGCATTAAGAAACAGTTCC	0.637000													44	111					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42196398	42196398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42196398G>A	ENST00000541110.1	-	18	3916	c.3348C>T	c.(3346-3348)ttC>ttT	p.F1116F	TRERF1_ENST00000340840.2_Silent_p.F1025F|TRERF1_ENST00000354325.2_Silent_p.F1013F|TRERF1_ENST00000372917.4_Silent_p.F1025F|TRERF1_ENST00000372922.4_Silent_p.F1096F			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1096	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TTTTGATCTTGAAGAAGACTC	0.468000													159	344					0	0	1	0	0
LPCAT1	79888	broad.mit.edu	37	5	1474126	1474126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1474126G>A	ENST00000283415.3	-	11	1257	c.1125C>T	c.(1123-1125)tcC>tcT	p.S375S		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	375					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		GGACTTCCAGGGAGGCGGCAA	0.532000													19	34					0	0	1	0	0
YTHDF2	51441	broad.mit.edu	37	1	29070059	29070059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:29070059C>T	ENST00000373812.3	+	4	1639	c.1277C>T	c.(1276-1278)tCc>tTc	p.S426F	YTHDF2_ENST00000542507.1_Missense_Mutation_p.S426F|YTHDF2_ENST00000541996.1_Missense_Mutation_p.S376F|YTHDF2_ENST00000478283.1_3'UTR	NM_016258.2	NP_057342.2	Q9Y5A9	YTHD2_HUMAN	YTH domain family, member 2	426	YTH.				humoral immune response					NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		ATTCACCGTTCCATTAAGTAT	0.423000													9	104					0	0	1	0	0
MSH5-SAPCD1	100532732	broad.mit.edu	37	6	31728484	31728484	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31728484C>T	ENST00000493662.2	+	20	1937	c.1881C>T	c.(1879-1881)ttC>ttT	p.F627F	MSH5_ENST00000375740.3_Silent_p.F627F|MSH5_ENST00000375750.3_Silent_p.F610F|MSH5_ENST00000375755.3_Silent_p.F610F|MSH5_ENST00000375742.3_Silent_p.F627F|MSH5_ENST00000534153.4_Silent_p.F627F|MSH5_ENST00000395853.1_Silent_p.F284F|MSH5_ENST00000431848.2_Silent_p.F309F|MSH5_ENST00000375703.3_Silent_p.F610F																							TGATCACATTCATGGCCCTGG	0.557000													44	99					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62039787	62039787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62039787C>T	ENST00000354587.3	-	16	2066	c.1890G>A	c.(1888-1890)cgG>cgA	p.R630R	KCNQ2_ENST00000357249.2_Silent_p.R604R|KCNQ2_ENST00000344462.3_Silent_p.R618R|KCNQ2_ENST00000359125.2_Silent_p.R622R|KCNQ2_ENST00000370224.1_Silent_p.R630R|KCNQ2_ENST00000370226.1_Silent_p.R592R|KCNQ2_ENST00000360480.3_Silent_p.R594R|KCNQ2_ENST00000359689.1_Silent_p.R622R|KCNQ2_ENST00000430658.1_Silent_p.R591R			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	622					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CCTTCCCGAGCCGTCCCATCA	0.706000													6	19					0	0	1	0	0
OR6C70	390327	broad.mit.edu	37	12	55863470	55863470	+	Silent	SNP	G	G	A	rs147384913		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55863470G>A	ENST00000327335.4	-	1	452	c.453C>T	c.(451-453)ttC>ttT	p.F151F	RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA	NM_001005499.1	NP_001005499.1	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C, member 70	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F151F(1)		autonomic_ganglia(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	18						AAATGATCAGGAATCCAGTTA	0.368000													24	60					0	0	1	0	0
SERPINA11	256394	broad.mit.edu	37	14	94909498	94909498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94909498G>A	ENST00000334708.3	-	4	1046	c.982C>T	c.(982-984)Ccc>Tcc	p.P328S	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	328					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		CCAATTTGGGGAAGTATGTCT	0.438000													33	88					0	0	1	0	0
TMEM190	147744	broad.mit.edu	37	19	55889357	55889357	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55889357G>A	ENST00000291934.3	+	5	338	c.320G>A	c.(319-321)cGg>cAg	p.R107Q	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	107						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GCCAAGCGCCGGGACGTGCTG	0.711000													13	35					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	375943	375943	+	Missense_Mutation	SNP	C	C	T	rs141910884		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:375943C>T	ENST00000342640.4	-	1	70	c.28G>A	c.(28-30)Ggg>Agg	p.G10R	THEG_ENST00000346878.2_Missense_Mutation_p.G10R	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	10					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGTTCCCGAGTGACCTT	0.692000													12	62					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656605	19656605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19656605C>T	ENST00000586018.1	+	8	3371	c.3269C>T	c.(3268-3270)tCc>tTc	p.S1090F	CILP2_ENST00000291495.4_Missense_Mutation_p.S1084F			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1084						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						TTTGATGGTTCCTCTGACGGC	0.627000													9	14					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774681	121774681	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121774681C>T	ENST00000264808.3	-	3	432	c.192G>A	c.(190-192)aaG>aaA	p.K64K	PRDM5_ENST00000428209.2_Silent_p.K64K|PRDM5_ENST00000515109.1_Silent_p.K64K|PRDM5_ENST00000394435.2_Silent_p.K64K	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	64	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AAACTTCTCCCTTACTCCCAC	0.448000													28	338					0	0	1	0	0
CLDN8	9073	broad.mit.edu	37	21	31587956	31587956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31587956C>T	ENST00000399899.1	-	1	435	c.288G>A	c.(286-288)atG>atA	p.M96I	CLDN8_ENST00000286809.1_Missense_Mutation_p.M96I	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	96					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						GGATGGCCATCATGAAAGCCA	0.522000													17	49					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230902211	230902211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230902211G>A	ENST00000295190.4	-	5	1876	c.1418C>T	c.(1417-1419)tCc>tTc	p.S473F		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	473						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TATGTAGAAGGAAAAATCATA	0.323000													20	47					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165602	151165602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151165602C>T	ENST00000282466.3	-	4	2166	c.2167G>A	c.(2167-2169)Gaa>Aaa	p.E723K		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	723					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGTGTTAATTCCCGATAGTTG	0.493000													28	46					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67260957	67260957	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67260957A>G	ENST00000392676.3	-	24	3298	c.3234T>C	c.(3232-3234)ttT>ttC	p.F1078F	ABCA5_ENST00000588877.1_Silent_p.F1078F|ABCA5_ENST00000392677.2_Silent_p.F1079F			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	1078					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					TAAGAATGATAAAAAATAAGG	0.308000													26	95					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35832673	35832673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35832673C>T	ENST00000085219.5	+	9	1906	c.1840C>T	c.(1840-1842)Ctg>Ttg	p.L614L	CD22_ENST00000536635.2_Silent_p.L526L|CD22_ENST00000270311.6_Silent_p.L494L|CD22_ENST00000544992.2_Silent_p.L614L|CD22_ENST00000594250.1_Silent_p.L437L|CD22_ENST00000419549.2_Silent_p.L442L|CD22_ENST00000341773.6_Silent_p.L437L	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	614	Ig-like C2-type 6.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GAGTGCAACCCTGACCTGTGA	0.617000													14	46					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105833949	105833949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105833949C>T	ENST00000353479.5	-	6	662	c.372G>A	c.(370-372)aaG>aaA	p.K124K	COL17A1_ENST00000369733.3_Silent_p.K124K|COL17A1_ENST00000393211.3_Silent_p.K124K	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	124	Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TACCAAATTCCTTCCGAGGGT	0.488000													52	117					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61659025	61659025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:61659025G>A	ENST00000381103.2	+	14	1565	c.1080G>A	c.(1078-1080)agG>agA	p.R360R	KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000506857.1_Silent_p.R334R|KIF2A_ENST00000407818.3_Silent_p.R380R|KIF2A_ENST00000401507.3_Silent_p.R380R	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	380	Kinesin-motor.				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		TGCTAAACAGGAAAACAAAAT	0.378000													4	13					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248039286	248039286	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248039286G>A	ENST00000366481.3	+	6	1004	c.956G>A	c.(955-957)tGg>tAg	p.W319*	OR2W3_ENST00000537741.1_5'UTR	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	319	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGAGAACCATGGAGGGATGTC	0.582000													21	33					0	0	1	0	0
REEP3	221035	broad.mit.edu	37	10	65379551	65379551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:65379551C>T	ENST00000373758.4	+	7	885	c.702C>T	c.(700-702)ggC>ggT	p.G234G	REEP3_ENST00000298249.4_Silent_p.G219G	NM_001001330.2	NP_001001330.1	Q6NUK4	REEP3_HUMAN	receptor accessory protein 3	234						integral to membrane				endometrium(1)|large_intestine(2)|lung(3)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCACCAAAGGCCGCAAAGAGG	0.398000													4	13					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25684929	25684929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25684929G>A	ENST00000376351.3	+	3	1457	c.1098G>A	c.(1096-1098)gtG>gtA	p.V366V		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	366						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TCTTACCAGTGAACAACTTTC	0.358000													13	37					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541132	55541132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55541132C>T	ENST00000361760.1	+	1	219	c.219C>T	c.(217-219)ttC>ttT	p.F73F		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TGACAGACTTCTGTTTTTCCA	0.388000													39	110					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45410212	45410212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45410212C>T	ENST00000332700.6	-	4	1048	c.877G>A	c.(877-879)Gag>Aag	p.E293K		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	293						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GGAGAATTCTCCCTCCATCTT	0.498000													34	77					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170076982	170076982	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170076982G>C	ENST00000263816.3	-	34	5915	c.5630C>G	c.(5629-5631)aCt>aGt	p.T1877S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1877					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGGATCAACAGTTATGCCAAT	0.418000													20	47					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172062837	172062837	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:172062837G>A	ENST00000355305.5	+	14	1704	c.1545_splice	c.e14-1	p.G516_splice	DNM3_ENST00000367733.2_Intron|DNM3_ENST00000367731.1_Intron|DNM3_ENST00000520906.1_Intron|DNM3_ENST00000358155.4_Intron			Q9UQ16	DYN3_HUMAN	dynamin 3	516	PH.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CTATTTCAGGGAACCAATCTT	0.333000													19	77					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52496389	52496389	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52496389C>T	ENST00000216286.5	-	10	2276	c.2277G>A	c.(2275-2277)ccG>ccA	p.P759P	NID2_ENST00000541773.1_Silent_p.P706P	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	759	EGF-like 2.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					AAGGATTCCCCGGAGTGGGGT	0.517000													8	40					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58260778	58260778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58260778G>A	ENST00000300896.4	-	31	4065	c.3871C>T	c.(3871-3873)Cgg>Tgg	p.R1291W	USP32_ENST00000592339.1_Missense_Mutation_p.R961W	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1291					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TTTATCCACCGACCATTTACA	0.378000													35	80					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45664637	45664637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45664637C>T	ENST00000322157.4	+	9	1259	c.1022C>T	c.(1021-1023)tCa>tTa	p.S341L	NPEPPS_ENST00000544660.1_Missense_Mutation_p.S261L|NPEPPS_ENST00000525037.1_3'UTR|NPEPPS_ENST00000530173.1_Missense_Mutation_p.S337L	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	341					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						TCCTGTTCTTCATCCCGCCAG	0.353000													3	13					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178682	65178682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:65178682G>A	ENST00000310045.7	-	2	4667	c.3194C>T	c.(3193-3195)cCa>cTa	p.P1065L	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1055						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				TAAATGCTCTGGTACATTCTT	0.358000													26	50					0	0	1	0	0
COX4I1	1327	broad.mit.edu	37	16	85840354	85840354	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:85840354C>T	ENST00000562336.1	+	5	577	c.384C>T	c.(382-384)ccC>ccT	p.P128P	COX4I1_ENST00000568794.1_3'UTR|COX4I1_ENST00000564903.1_3'UTR|COX4I1_ENST00000561569.1_Silent_p.P128P|COX4I1_ENST00000253452.2_Silent_p.P128P			P13073	COX41_HUMAN	cytochrome c oxidase subunit IV isoform 1	128					respiratory electron transport chain	mitochondrial inner membrane|nucleus	cytochrome-c oxidase activity|protein binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9		Renal(780;0.228)				TGTACGGCCCCCTCCCGCAAA	0.542000													22	64					0	0	1	0	0
DPYSL3	1809	broad.mit.edu	37	5	146785234	146785234	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:146785234G>A	ENST00000343218.5	-	8	1289	c.1092C>T	c.(1090-1092)ctC>ctT	p.L364L	DPYSL3_ENST00000534907.1_Intron|DPYSL3_ENST00000398514.3_Silent_p.L250L	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	250					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTGACGTAGAGAGGGCAAT	0.498000													102	224					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32020753	32020753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32020753G>A	ENST00000375244.3	-	26	9010	c.8809C>T	c.(8809-8811)Ccc>Tcc	p.P2937S	TNXB_ENST00000375247.2_Missense_Mutation_p.P2935S			P22105	TENX_HUMAN	tenascin XB	2982	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GTGGGGGCGGGAGTTTCTTCC	0.642000													18	53					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43508587	43508587	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43508587G>A	ENST00000300215.3	-	2	622	c.165C>T	c.(163-165)gcC>gcT	p.A55A	EPB42_ENST00000441366.2_Silent_p.A25A|EPB42_ENST00000540029.1_Silent_p.A25A			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	25					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GGGAGCTGAGGGCCTTGGTGT	0.562000													9	95					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170964646	170964646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:170964646G>A	ENST00000367759.4	+	13	1465	c.1311G>A	c.(1309-1311)ctG>ctA	p.L437L	MROH9_ENST00000367758.3_Silent_p.L437L	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		ACAGTGAGCTGAAACCGATAC	0.458000													27	70					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22061092	22061092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:22061092G>A	ENST00000261200.4	-	9	1373	c.1374C>T	c.(1372-1374)gtC>gtT	p.V458V	ABCC9_ENST00000261201.4_Silent_p.V458V|ABCC9_ENST00000345162.2_Silent_p.V458V	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	458	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGCTGCACCGACCAATGCAC	0.413000													21	40					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7776939	7776939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7776939G>A	ENST00000358415.4	+	15	2008	c.1842G>A	c.(1840-1842)caG>caA	p.Q614Q	ITIH2_ENST00000379587.4_Silent_p.Q603Q	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	614					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CGATCCTGCAGATGTCTCTAG	0.552000													34	94					0	0	1	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940552	67940552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:67940552G>A	ENST00000357461.2	-	3	498	c.89C>T	c.(88-90)gCc>gTc	p.A30V	TMEM229B_ENST00000557006.1_Missense_Mutation_p.A30V	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	30						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						GAACTCCCAGGCCGCTGTGAA	0.627000													8	21					0	0	1	0	0
PELO	53918	broad.mit.edu	37	5	52096834	52096834	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52096834A>T	ENST00000274311.2	+	2	1591	c.606A>T	c.(604-606)gtA>gtT	p.V202V	ITGA1_ENST00000282588.6_Intron|PELO_ENST00000506949.1_Intron|ITGA1_ENST00000504086.1_Intron	NM_015946.4	NP_057030.3	Q9BRX2	PELO_HUMAN	pelota homolog (Drosophila)	202					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	11		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				TTGATGTTGTAAAGTGCATCC	0.517000													41	78					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45015121	45015121	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45015121G>A	ENST00000454753.1	-	0	1983							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				TTGGCACAGTGGAGACCAATC	0.493000													15	41					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159650906	159650906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159650906C>T	ENST00000297267.9	+	10	1440	c.1240C>T	c.(1240-1242)Cct>Tct	p.P414S	FNDC1_ENST00000340366.6_Intron	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	414	Fibronectin type-III 4.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CCTCACCTATCCTGGAGACAC	0.507000													29	232					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155171642	155171642	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:155171642G>A	ENST00000262640.6	+	7	705	c.622G>A	c.(622-624)Gat>Aat	p.D208N	VAMP7_ENST00000460621.1_3'UTR|VAMP7_ENST00000286448.6_3'UTR	NM_001185183.1	NP_001172112.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	0					calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATTAACCAAGGATATGAGAGA	0.408000													11	47					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064875	7064875	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7064875C>T	ENST00000299481.4	+	4	1964	c.1618C>T	c.(1618-1620)Cga>Tga	p.R540*		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	540					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GAATGAAGATCGAGTAAAACA	0.348000													31	89					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54612349	54612349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:54612349G>A	ENST00000302287.3	+	2	520	c.114G>A	c.(112-114)gcG>gcA	p.A38A	VSTM2A_ENST00000407838.3_Silent_p.A38A|VSTM2A_ENST00000402026.2_Silent_p.A37A|VSTM2A_ENST00000402613.3_Silent_p.A38A|VSTM2A_ENST00000404951.1_Silent_p.A38A			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	38	Ig-like V-type.					extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			ACGTGACGGCGACCGAGGGGC	0.577000													17	55					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567106	45567106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:45567106C>T	ENST00000588982.1	-	3	874	c.373G>A	c.(373-375)Gag>Aag	p.E125K	ZBTB7C_ENST00000586438.1_Missense_Mutation_p.E125K|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.E125K|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.E125K|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.E125K			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	125	Glu-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						TCCATGATCTCCAGGCACACG	0.592000													4	33					0	0	1	0	0
TUBG1	7283	broad.mit.edu	37	17	40762196	40762196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40762196C>T	ENST00000251413.3	+	2	182	c.120C>T	c.(118-120)ttC>ttT	p.F40F	FAM134C_ENST00000585894.1_Intron	NM_001070.4	NP_001061.2	P23258	TBG1_HUMAN	tubulin, gamma 1	40					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TGGAGGAGTTCGCCACCGAGG	0.657000													45	76					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176210	57176210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57176210G>A	ENST00000537055.2	-	2	588	c.357C>T	c.(355-357)ttC>ttT	p.F119F		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						AACAGTAGCTGAAGGCCTTCC	0.632000													12	123					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151085969	151085969	+	Silent	SNP	G	G	A	rs146195573		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151085969G>A	ENST00000474524.1	+	23	3413	c.3375G>A	c.(3373-3375)gcG>gcA	p.A1125A	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Silent_p.A985A	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1125					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGCCTGGGGCGAGAATGACAT	0.517000													9	54					0	0	1	0	0
ABO	28	broad.mit.edu	37	9	136131706	136131706	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136131706C>T	ENST00000453660.2	-	0	422							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		AAGTGCTTCTCCGCCGTCTCC	0.692000													24	66					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79028820	79028820	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79028820C>T	ENST00000446378.2	+	2	4263	c.4232C>T	c.(4231-4233)tCa>tTa	p.S1411L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1411						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GATGAACATTCAGTTCTTGCA	0.408000													9	27					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106976817	106976817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106976817G>A	ENST00000369701.3	+	19	2898	c.2671G>A	c.(2671-2673)Gtg>Atg	p.V891M	SORCS3_ENST00000369699.4_Missense_Mutation_p.V177M	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	891	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GATCTTCCAGGTGACAGCCTA	0.532000													27	54					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120288	38120288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38120288C>T	ENST00000406386.3	+	7	1980	c.1725C>T	c.(1723-1725)ccC>ccT	p.P575P	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	575					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GAGACAACCCCAGAACATCCT	0.582000													31	179					0	0	1	0	0
RILP	83547	broad.mit.edu	37	17	1549859	1549859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:1549859G>A	ENST00000301336.6	-	8	1355	c.1083C>T	c.(1081-1083)agC>agT	p.S361S		NM_031430.2	NP_113618.2	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	361					endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(4)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGGGTGCAGGGCTGCTGGTCT	0.592000													58	61					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115574931	115574931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:115574931G>A	ENST00000371900.4	+	5	717	c.629G>A	c.(628-630)gGg>gAg	p.G210E		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	210					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	TATCAGCCAGGGCAGCTTCCC	0.328000													31	30					0	0	1	0	0
SYNM	23336	broad.mit.edu	37	15	99670140	99670140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:99670140C>T	ENST00000336292.6	+	5	1692	c.1572C>T	c.(1570-1572)ttC>ttT	p.F524F	SYNM_ENST00000560674.1_Silent_p.F239F|RP11-6O2.4_ENST00000566974.1_RNA|SYNM_ENST00000561323.1_3'UTR|SYNM_ENST00000328642.7_Silent_p.F524F	NM_145728.2	NP_663780.2	O15061	SYNEM_HUMAN	synemin, intermediate filament protein	525	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(6)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	29						AGAAAATGTTCGATTCTAAAG	0.448000													21	21					0	0	1	0	0
TAB2	23118	broad.mit.edu	37	6	149720247	149720247	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:149720247T>C	ENST00000367456.1	+	7	2443	c.1866T>C	c.(1864-1866)caT>caC	p.H622H	TAB2_ENST00000536230.1_Silent_p.H590H|TAB2_ENST00000286332.5_Silent_p.H622H|TAB2_ENST00000538427.1_Silent_p.H622H			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2	622					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						CAGGACCACATTTTAACCCCA	0.303000													15	22					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663471	34663471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34663471C>T	ENST00000488417.1	+	2	1086	c.966C>T	c.(964-966)tcC>tcT	p.S322S	C1orf94_ENST00000373374.3_Silent_p.S132S	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	132							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AGATCTGTTCCAAGCCCAAGG	0.612000													18	35					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123615708	123615708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:123615708C>T	ENST00000422452.2	-	22	3886	c.3823G>A	c.(3823-3825)Gag>Aag	p.E1275K	TENM1_ENST00000371130.3_Missense_Mutation_p.E1268K|TENM1_ENST00000461429.1_5'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TCTTTCGTCTCCACAAGAGAT	0.458000													20	72					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23065152	23065152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23065152C>T	ENST00000246006.4	-	1	1825	c.1678G>A	c.(1678-1680)Gag>Aag	p.E560K		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	560					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCTGCAGGCTCCTGGGGGCCA	0.617000													34	69					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681346	100681346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100681346G>A	ENST00000306151.4	+	3	6713	c.6649G>A	c.(6649-6651)Gaa>Aaa	p.E2217K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2217	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAAGGAAGCAC	0.507000													235	563					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871891	51871891	+	Missense_Mutation	SNP	G	G	A	rs141129077		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51871891G>A	ENST00000371497.5	+	2	2781	c.1894G>A	c.(1894-1896)Gat>Aat	p.D632N	TSHZ2_ENST00000603338.2_Missense_Mutation_p.D629N|TSHZ2_ENST00000329613.6_Missense_Mutation_p.D629N	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	632					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CAGTGAGGGCGATTCTTTCCG	0.512000													21	75					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886286	123886286	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123886286C>T	ENST00000320891.4	+	1	5	c.5C>T	c.(4-6)tCc>tTc	p.S2F		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GAAGAAATGTCCAACGCCAGC	0.512000													17	100					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110535020	110535020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110535020G>A	ENST00000378402.5	+	75	12335	c.12231G>A	c.(12229-12231)gtG>gtA	p.V4077V		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	4077					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCATCACGTGGCCTTCGTGT	0.512000										HNSCC(38;0.096)			11	29					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10468807	10468807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10468807G>A	ENST00000382483.3	-	4	3024	c.2801C>T	c.(2800-2802)cCc>cTc	p.P934L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	934					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTGCCCCTGGGGGCCTCCCCC	0.657000													15	39					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82834819	82834819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82834819C>T	ENST00000265077.3	+	8	6562	c.5997C>T	c.(5995-5997)ttC>ttT	p.F1999F	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.F1012F|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1999	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTTCAGCCTTCCCCTGGGAAG	0.512000													22	54					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328049	126328049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126328049C>T	ENST00000394329.3	+	3	5335	c.5322C>T	c.(5320-5322)ctC>ctT	p.L1774L	FAT4_ENST00000335110.5_Silent_p.L72L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1774	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAAATGCTCTCGTCACATACA	0.433000													31	104					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724711	49724711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49724711C>T	ENST00000551245.1	+	13	2194	c.2083C>T	c.(2083-2085)Cca>Tca	p.P695S	TROAP_ENST00000257909.3_Missense_Mutation_p.P695S|TROAP_ENST00000547923.1_Missense_Mutation_p.P374S			Q12815	TROAP_HUMAN	trophinin associated protein	695					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						TTTGAGACCCCCAGCAGGCCA	0.607000													44	163					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60230367	60230367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:60230367C>T	ENST00000269499.5	+	9	2094	c.1676C>T	c.(1675-1677)tCg>tTg	p.S559L	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.S238L	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	559					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						TGTGTGACCTCGGCTGACCAG	0.428000													23	76					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6634900	6634900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6634900G>A	ENST00000333172.6	+	3	901	c.708G>A	c.(706-708)ggG>ggA	p.G236G	TAS1R1_ENST00000351136.3_Intron|TAS1R1_ENST00000328191.4_Silent_p.G236G	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	236					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTCAGGGGATCTGCATTG	0.622000													34	55					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35802590	35802590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35802590C>T	ENST00000342694.2	+	11	2056	c.1801C>T	c.(1801-1803)Cgt>Tgt	p.R601C		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	601	Protein kinase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ATACTGTCCTCGTGGGAGTTT	0.488000													22	65					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28465784	28465784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28465784G>A	ENST00000261609.7	-	37	5767	c.5659C>T	c.(5659-5661)Cct>Tct	p.P1887S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1887	MIB/HERC2.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CCTGGAGGAGGCCCATCCTGA	0.582000													34	90					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129251120	129251120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129251120C>T	ENST00000296271.3	+	3	651	c.557C>T	c.(556-558)tCg>tTg	p.S186L		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	186			S -> P (in RP4).		protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	CTGCAGTGCTCGTGTGGAATC	0.572000													23	62					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33141495	33141495	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33141495C>T	ENST00000341947.2	-	35	2838	c.2611G>A	c.(2611-2613)Ggg>Agg	p.G871R	COL11A2_ENST00000374714.1_Missense_Mutation_p.G845R|COL11A2_ENST00000361917.1_Missense_Mutation_p.G764R|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000395197.1_Missense_Mutation_p.G811R|COL11A2_ENST00000374713.1_Missense_Mutation_p.G824R|COL11A2_ENST00000374712.1_Missense_Mutation_p.G790R|COL11A2_ENST00000374708.4_Missense_Mutation_p.G785R|COL11A2_ENST00000357486.1_Missense_Mutation_p.G850R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	871	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCAGGGGGCCCATGGGGGCCA	0.627000													10	19					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175833	140175833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140175833G>A	ENST00000526136.1	+	1	1284	c.1284G>A	c.(1282-1284)cgG>cgA	p.R428R	PCDHA2_ENST00000378132.1_Silent_p.R428R|PCDHA2_ENST00000520672.2_Silent_p.R428R|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACCGCACGGGACGGGGGCT	0.632000													70	124					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64825409	64825409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64825409C>T	ENST00000358658.3	-	3	445	c.418G>A	c.(418-420)Gag>Aag	p.E140K	NAALADL1_ENST00000339885.2_Missense_Mutation_p.E140K|NAALADL1_ENST00000355721.3_Missense_Mutation_p.E140K|NAALADL1_ENST00000356632.3_Missense_Mutation_p.E140K|NAALADL1_ENST00000355369.2_Missense_Mutation_p.E140K|NAALADL1_ENST00000340252.4_Missense_Mutation_p.E140K	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	140					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CCCCCTTGCTCCCCGGTCACG	0.647000													37	83					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176314494	176314494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176314494G>A	ENST00000292432.5	-	11	1649	c.1558C>T	c.(1558-1560)Cgc>Tgc	p.R520C		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	520	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCAGCATGCGAAGGGAGGAG	0.652000													16	29					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85399759	85399759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85399759G>A	ENST00000258888.5	+	6	2563	c.2396G>A	c.(2395-2397)aGa>aAa	p.R799K		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	799					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GAGGATGGGAGAACATCTGCT	0.517000													47	76					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49688217	49688217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49688217C>T	ENST00000296452.4	+	4	1805	c.1691C>T	c.(1690-1692)cCt>cTt	p.P564L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	564					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTGGGCCAGCCTTCAGGCCCC	0.687000													28	208					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8601135	8601135	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8601135C>T	ENST00000338257.8	-	19	2311		c.e19+1			NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF							unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						AACACACTCACCGACTCTGGG	0.567000													16	102					0	0	1	0	0
MAOA	4128	broad.mit.edu	37	X	43571967	43571967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:43571967C>T	ENST00000338702.3	+	5	550	c.427C>T	c.(427-429)Ccc>Tcc	p.P143S	MAOA_ENST00000497485.1_3'UTR|MAOA_ENST00000542639.1_Missense_Mutation_p.P10S	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	143					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	AACTGATGCACCCTGGGAGGC	0.453000													17	13					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27801613	27801613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27801613G>A	ENST00000408964.2	+	1	2225	c.2174G>A	c.(2173-2175)gGg>gAg	p.G725E		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	725										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					TTACAAGTAGGGACTGACTTC	0.428000													37	88					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82595399	82595399	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82595399G>A	ENST00000423517.2	-	4	4042	c.3705C>T	c.(3703-3705)ctC>ctT	p.L1235L	PCLO_ENST00000333891.8_Silent_p.L1235L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1174					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTCTTCTAGGAGTGGCTTTT	0.388000													94	281					0	0	1	0	0
TAF1A	9015	broad.mit.edu	37	1	222737456	222737456	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:222737456C>T	ENST00000350027.4	-	8	1059	c.906G>A	c.(904-906)caG>caA	p.Q302Q	TAF1A_ENST00000391882.1_Silent_p.Q188Q|TAF1A_ENST00000352967.4_Silent_p.Q302Q|TAF1A_ENST00000366890.1_Silent_p.Q188Q	NM_001201536.1	NP_001188465.1	Q15573	TAF1A_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	302					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding			kidney(3)|large_intestine(3)|lung(11)|urinary_tract(1)	18				GBM - Glioblastoma multiforme(131;0.0186)		ATGGTACAATCTGATACAAAA	0.279000													29	79					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22155533	22155533	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22155533T>C	ENST00000397126.4	-	4	2451	c.2303A>G	c.(2302-2304)aAg>aGg	p.K768R	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATGAATTTTCTTATGATAACT	0.353000													16	59					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104031898	104031898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104031898G>A	ENST00000388887.2	+	8	1018	c.814G>A	c.(814-816)Ggc>Agc	p.G272S		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	272	EGF-like 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CCGTGGGGATGGCCAAGTGTG	0.498000													39	67					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669801	158669801	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158669801G>A	ENST00000359610.2	-	1	685	c.642C>T	c.(640-642)ctC>ctT	p.L214L		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					ACATGAAGATGAGCATCACAG	0.493000													46	80					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139727187	139727187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139727187G>A	ENST00000263549.3	-	10	2390	c.1517C>T	c.(1516-1518)tCc>tTc	p.S506F		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	506	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					CTCTTCCGAGGAAGAACTAAG	0.448000													43	100					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100933186	100933186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100933186G>A	ENST00000325455.5	-	4	3657	c.2204C>T	c.(2203-2205)tCa>tTa	p.S735L	PGR_ENST00000263463.5_Intron|PGR_ENST00000534013.1_Missense_Mutation_p.S141L	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	735	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	ACCTGGCAATGATTTAGACCA	0.328000													28	112					0	0	1	0	0
RHOT1	55288	broad.mit.edu	37	17	30526555	30526555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:30526555C>T	ENST00000358365.3	+	13	1313	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F	RHOT1_ENST00000333942.6_Silent_p.F362F|RHOT1_ENST00000581094.1_Silent_p.F362F|RHOT1_ENST00000583994.1_Silent_p.F235F|RHOT1_ENST00000545287.2_Silent_p.F362F|RHOT1_ENST00000354266.3_Silent_p.F341F|RHOT1_ENST00000394692.2_Silent_p.F362F	NM_001033568.1	NP_001028740.1	Q8IXI2	MIRO1_HUMAN	ras homolog family member T1	362					apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			NS(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				ACCAGGGATTCCTTTCCCAGT	0.378000													29	42					0	0	1	0	0
FKRP	79147	broad.mit.edu	37	19	47258815	47258815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47258815C>T	ENST00000318584.5	+	4	405	c.108C>T	c.(106-108)gcC>gcT	p.A36A	FKRP_ENST00000600646.1_Intron|FKRP_ENST00000391909.3_Silent_p.A36A	NM_001039885.2|NM_024301.4	NP_001034974.1|NP_077277.1	Q9H9S5	FKRP_HUMAN	fukutin related protein	36						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			NS(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		ATTCCCGGGCCCGGGGGCCCC	0.677000													3	16					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	271138	271138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:271138C>T	ENST00000538872.1	+	8	2608	c.2490C>T	c.(2488-2490)atC>atT	p.I830I	IQSEC3_ENST00000382841.2_Silent_p.I527I|IQSEC3_ENST00000326261.4_Silent_p.I830I			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	830	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TGGTAGGCATCTATGAGAGGA	0.577000													5	18					0	0	1	0	0
HIBADH	11112	broad.mit.edu	37	7	27582693	27582693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27582693G>A	ENST00000265395.2	-	5	717	c.511C>T	c.(511-513)Ctc>Ttc	p.L171F		NM_152740.3	NP_689953.1	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase	171					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(4)|kidney(2)|lung(3)|ovary(2)|prostate(1)	12			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	ATAAACGTGAGGTTCCCAGAT	0.458000													24	42					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139192923	139192923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139192923G>A	ENST00000274710.3	+	3	606	c.401G>A	c.(400-402)cGg>cAg	p.R134Q		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	134					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGATGTGCGGGATGGCTTC	0.612000													25	99					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85438259	85438259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85438259C>T	ENST00000394573.1	+	6	568	c.366C>T	c.(364-366)ttC>ttT	p.F122F	SLC28A1_ENST00000338602.2_Silent_p.F122F|SLC28A1_ENST00000537624.1_Silent_p.F122F|SLC28A1_ENST00000537703.1_Silent_p.F44F|SLC28A1_ENST00000537216.1_Silent_p.F122F|SLC28A1_ENST00000538177.1_Silent_p.F122F|SLC28A1_ENST00000286749.3_Silent_p.F122F	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	122					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCCTCACCTTCCTGGGCCACC	0.622000													10	167					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38320156	38320156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38320156C>T	ENST00000264645.7	+	7	1434	c.1208C>T	c.(1207-1209)tCc>tTc	p.S403F		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	403	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						GAGAAGAAATCCTATTCCCGG	0.567000													19	119					0	0	1	0	0
C9orf139	401563	broad.mit.edu	37	9	139929438	139929438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139929438G>A	ENST00000314330.2	+	3	2019	c.505G>A	c.(505-507)Ggg>Agg	p.G169R		NM_207511.1	NP_997394.1	Q6ZV77	CI139_HUMAN	chromosome 9 open reading frame 139	169										cervix(1)|lung(2)	3	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		GGAAAGAAAAGGGCATGAGTC	0.622000													13	114					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132177606	132177606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:132177606G>A	ENST00000374786.1	+	4	1029	c.550G>A	c.(550-552)Gaa>Aaa	p.E184K	NTM_ENST00000539799.1_Missense_Mutation_p.E184K|NTM_ENST00000374784.1_Missense_Mutation_p.E184K|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000374791.3_Missense_Mutation_p.E184K|NTM_ENST00000425719.2_Missense_Mutation_p.E184K|NTM_ENST00000427481.2_Missense_Mutation_p.E175K	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	184	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane		p.E184K(2)|p.E184*(2)		breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						GAGTGAAGACGAATACTTGGA	0.493000													23	59					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99441317	99441317	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:99441317C>T	ENST00000287042.4	+	2	1460	c.1110C>T	c.(1108-1110)gtC>gtT	p.V370V	KCNS2_ENST00000521839.1_Silent_p.V370V	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	370						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GGGCTACCGTCAGTATGACCA	0.617000													23	51					0	0	1	0	0
CHST12	55501	broad.mit.edu	37	7	2473276	2473276	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2473276C>T	ENST00000258711.6	+	2	1137	c.1002C>T	c.(1000-1002)atC>atT	p.I334I		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	334					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CGTGCCAGATCGACTACGACT	0.657000													7	58					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101710325	101710325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:101710325G>A	ENST00000251127.6	-	43	5070	c.4989C>T	c.(4987-4989)ccC>ccT	p.P1663P	NALCN-AS1_ENST00000457843.1_RNA	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1663						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATTTCCTCTGGGGTTTCCCTG	0.562000													18	62					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32010529	32010529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:32010529G>A	ENST00000438447.1	+	6	1736	c.1348G>A	c.(1348-1350)Gaa>Aaa	p.E450K	PDZD2_ENST00000282493.3_Missense_Mutation_p.E450K			O15018	PDZD2_HUMAN	PDZ domain containing 2	450					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GACTGATAACGAAGACCAGGA	0.522000													18	91					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714363	70714363	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70714363C>T	ENST00000530196.1	-	0	155					NR_003951.1																						ACACTAGGGTCCCATCCACTG	0.527000													50	103					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134990687	134990687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:134990687G>A	ENST00000535938.1	+	12	1519	c.1352G>A	c.(1351-1353)cGa>cAa	p.R451Q	SAGE1_ENST00000537770.1_Intron|SAGE1_ENST00000370709.3_Missense_Mutation_p.R451Q|SAGE1_ENST00000324447.3_Missense_Mutation_p.R451Q	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	451								p.R451Q(1)		breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					AATGGCCAACGAAAACAGGAT	0.428000													77	70					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	124097438	124097438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:124097438C>T	ENST00000422452.2	-	1	228	c.165G>A	c.(163-165)atG>atA	p.M55I	TENM1_ENST00000371130.3_Missense_Mutation_p.M55I	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TATTGTAATTCATCCTCAGCT	0.373000													106	82					0	0	1	0	0
VPS45	11311	broad.mit.edu	37	1	150065671	150065671	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150065671C>T	ENST00000369130.3	+	13	1966	c.1420C>T	c.(1420-1422)Ctg>Ttg	p.L474L	VPS45_ENST00000535106.1_Silent_p.L405L|VPS45_ENST00000369128.5_Silent_p.L369L	NM_007259.3	NP_009190.2	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45 homolog (S. cerevisiae)	474					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACATGAAACCCTGGATCATCT	0.373000													43	89					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38319978	38319978	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38319978A>T	ENST00000264645.7	+	7	1256	c.1030A>T	c.(1030-1032)Aag>Tag	p.K344*		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	344					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						TGAGACTGTTAAGCATGAGAT	0.547000													85	90					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77286708	77286708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77286708G>A	ENST00000376896.2	+	9	1727	c.1115G>A	c.(1114-1116)cGa>cAa	p.R372Q	RORB_ENST00000396204.2_Missense_Mutation_p.R383Q	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	383	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						TCATCAGACCGAGCCTGGCTT	0.408000													18	52					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85985238	85985238	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85985238G>T	ENST00000372113.4	-	1	44	c.39C>A	c.(37-39)gtC>gtA	p.V13V	LRIT2_ENST00000538192.1_Silent_p.V13V	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	13						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						TATCCAGAAAGACCAGAACTA	0.478000													13	34					3.27435e-08	3.28482e-08	1	1	0
PIWIL3	440822	broad.mit.edu	37	22	25145731	25145731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25145731C>T	ENST00000332271.5	-	10	1561	c.1145G>A	c.(1144-1146)aGa>aAa	p.R382K	PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.R273K|PIWIL3_ENST00000533313.1_Missense_Mutation_p.R273K	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	382	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CTTTTTCCATCTGCCCTGGCT	0.463000													20	58					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101117834	101117834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:101117834G>A	ENST00000394095.2	-	6	601	c.548C>T	c.(547-549)cCa>cTa	p.P183L	SENP7_ENST00000314261.7_Missense_Mutation_p.P117L|SENP7_ENST00000358203.3_Intron|SENP7_ENST00000394091.1_Intron|SENP7_ENST00000348610.3_Missense_Mutation_p.P150L|SENP7_ENST00000394094.2_Intron	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	183					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AGTTACAGGTGGGGTCCTTAT	0.403000													33	75					0	0	1	0	0
GPAT2	150763	broad.mit.edu	37	2	96691678	96691678	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96691678C>T	ENST00000434632.1	-	13	1697	c.1238_splice	c.e13+1	p.C413_splice	GPAT2_ENST00000453542.1_Splice_Site_p.C342_splice|GPAT2_ENST00000359548.4_Splice_Site_p.C413_splice|GPAT2_ENST00000377137.3_Splice_Site_p.C413_splice			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	413					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						GTGCCCCTACCATTGGCCCAG	0.607000													20	48					0	0	1	0	0
TCAIM	285343	broad.mit.edu	37	3	44402978	44402978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44402978C>T	ENST00000342649.4	+	4	714	c.287C>T	c.(286-288)tCc>tTc	p.S96F	TCAIM_ENST00000417237.1_Missense_Mutation_p.S96F	NM_173826.3	NP_776187.2			T cell activation inhibitor, mitochondrial																		GACCAGAGTTCCTCCGATGGC	0.383000													11	76					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671604	39671604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39671604C>T	ENST00000398930.1	+	4	775	c.421C>T	c.(421-423)Cat>Tat	p.H141Y	KCNJ15_ENST00000398938.2_Missense_Mutation_p.H141Y|KCNJ15_ENST00000398932.1_Missense_Mutation_p.H141Y|KCNJ15_ENST00000398934.1_Missense_Mutation_p.H141Y|KCNJ15_ENST00000328656.3_Missense_Mutation_p.H141Y			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	141					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						GGAATGTCCTCATGCCATCTT	0.502000													30	86					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113348734	113348734	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113348734C>T	ENST00000458497.1	+	9	987	c.708C>T	c.(706-708)tcC>tcT	p.S236S	ALPK1_ENST00000177648.9_Silent_p.S236S|ALPK1_ENST00000504176.2_Silent_p.S158S	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	236							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AGGGCCTCTCCACGTCGCTAG	0.383000													6	69					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230928655	230928655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230928655G>A	ENST00000354537.1	+	16	1855	c.1773G>A	c.(1771-1773)cgG>cgA	p.R591R	RP11-99J16__A.2_ENST00000452640.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA|CAPN9_ENST00000366666.2_Silent_p.R554R|RP11-99J16__A.2_ENST00000428480.1_RNA|CAPN9_ENST00000271971.2_Silent_p.R617R|CAPN9_ENST00000480004.1_3'UTR	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	617	Domain IV.|EF-hand 2.|EF-hand 3.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				ATGAACTACGGACTGCACTGA	0.527000													64	115					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38990708	38990708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:38990708C>T	ENST00000318792.1	+	2	512	c.502C>T	c.(502-504)Cct>Tct	p.P168S		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	168										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		CCTCTCAGATCCTCTGGGGGT	0.527000													12	13					0	0	1	0	0
MYL10	93408	broad.mit.edu	37	7	101256771	101256771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101256771C>T	ENST00000223167.4	-	8	842	c.665G>A	c.(664-666)gGt>gAt	p.G222D		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	222	EF-hand 3.					mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						CTTCTCTTCACCGTGAGTGAT	0.547000													14	91					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074624	106074624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106074624G>A	ENST00000278071.2	-	3	1638	c.1186C>T	c.(1186-1188)Cta>Tta	p.L396L	ITPRIP_ENST00000358187.2_Silent_p.L396L|ITPRIP_ENST00000337478.1_Silent_p.L396L	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	396						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						AGTGCCTTTAGTGTCGTCCTG	0.642000													16	63					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210557911	210557911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:210557911C>T	ENST00000360351.4	+	7	1523	c.1017C>T	c.(1015-1017)ccC>ccT	p.P339P	MAP2_ENST00000361559.4_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Silent_p.P335P|MAP2_ENST00000199940.6_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	339					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AAACATCGCCCTTTGCCCCTG	0.438000													30	81					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717552	13717552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13717552C>T	ENST00000279593.3	-	13	2829	c.2620G>A	c.(2620-2622)Ggg>Agg	p.G874R		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	874					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATCGCCACCCCATGGATGCAG	0.527000													37	114					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112018759	112018759	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112018759C>T	ENST00000374566.3	-	8	1271	c.752_splice	c.e8-1	p.G252_splice	EPB41L4B_ENST00000374557.4_Splice_Site_p.G252_splice	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	252	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGGCTCTTTCCCCTTAGAAAA	0.473000													18	76					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92459677	92459677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:92459677C>T	ENST00000318445.6	+	2	849	c.635C>T	c.(634-636)tCg>tTg	p.S212L	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.S212L	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	212					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			AAGGACTCCTCGCTCTATATA	0.587000													3	22					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69387775	69387775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:69387775G>A	ENST00000193403.6	-	3	671	c.288C>T	c.(286-288)gcC>gcT	p.A96A	ACTN1_ENST00000538545.2_Silent_p.A96A|ACTN1_ENST00000376839.3_Silent_p.A31A|ACTN1_ENST00000438964.2_Silent_p.A96A|ACTN1_ENST00000394419.4_Silent_p.A96A	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	96	Actin-binding.|CH 1.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TGAAATCCAGGGCCTTGTTGA	0.547000													30	100					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10697863	10697863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:10697863C>T	ENST00000302079.6	-	41	6370	c.6371G>A	c.(6370-6372)cGa>cAa	p.R2124Q	PIEZO2_ENST00000538948.1_Missense_Mutation_p.R81Q|PIEZO2_ENST00000285141.4_5'UTR|PIEZO2_ENST00000580640.1_Missense_Mutation_p.R2149Q|PIEZO2_ENST00000503781.3_Missense_Mutation_p.R2124Q			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2124	Ser-rich.					integral to membrane	ion channel activity										ACTGCTGTTTCGGGTGCTTGT	0.403000													4	33					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004741	52004741	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52004741G>A	ENST00000291707.3	-	1	302	c.247C>T	c.(247-249)Cga>Tga	p.R83*		NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	83	Ig-like V-type 1.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGCACTGCTCGAGCTGGGTTG	0.572000													47	128					0	0	1	0	0
MIR329-1	574408	broad.mit.edu	37	14	101493187	101493187	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101493187C>T	ENST00000385028.1	+	0	66					NR_029967.1																						CCTGGTTAACCTCTTTTCCAG	0.463000													52	118					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49700328	49700328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49700328G>A	ENST00000296452.4	+	7	10851	c.10737G>A	c.(10735-10737)gaG>gaA	p.E3579E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3579					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TGGGCCAGGAGGAGACGGACT	0.612000													25	75					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38935268	38935268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38935268C>T	ENST00000355481.4	+	7	713	c.582C>T	c.(580-582)ttC>ttT	p.F194F	RYR1_ENST00000359596.3_Silent_p.F194F|RYR1_ENST00000360985.3_Silent_p.F194F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	194	MIR 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACGCTTCCTTCATGCAGACAC	0.622000													10	19					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129663406	129663406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129663406G>A	ENST00000358303.4	-	8	1262	c.1178C>T	c.(1177-1179)cCa>cTa	p.P393L	RP11-306G20.1_ENST00000587038.1_RNA|ZC3HC1_ENST00000360708.5_Intron|RP11-306G20.1_ENST00000480018.1_RNA|ZC3HC1_ENST00000311873.5_Missense_Mutation_p.P372L|ZC3HC1_ENST00000481503.1_Missense_Mutation_p.P350L	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	393					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					AGGGCTAGATGGTACCTCCAG	0.607000													47	116					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116224391	116224391	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116224391A>G	ENST00000374140.2	+	4	534	c.325A>G	c.(325-327)Agc>Ggc	p.S109G	RGS3_ENST00000350696.5_Missense_Mutation_p.S109G	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	109					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GGAGTGGCTAAGCCCTGATAT	0.557000													11	109					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104898241	104898241	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:104898241G>A	ENST00000507740.1	+	2	1074	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K	RIMS2_ENST00000262231.10_Missense_Mutation_p.E280K|RIMS2_ENST00000406091.3_Missense_Mutation_p.E472K|RIMS2_ENST00000436393.2_Missense_Mutation_p.E250K	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	503					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AACAAAACGGGAAAAAATGGA	0.448000										HNSCC(12;0.0054)			14	45					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40030130	40030130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40030130G>A	ENST00000372856.3	-	10	2217	c.1418C>T	c.(1417-1419)gCc>gTc	p.A473V	PABPC4_ENST00000372862.3_Intron|PABPC4_ENST00000372858.3_Missense_Mutation_p.A473V|PABPC4_ENST00000372857.3_Intron	NM_001135654.1	NP_001129126.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	486					blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCCACGAGAGGCCGGAGCATT	0.562000													49	120					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122853693	122853693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122853693C>T	ENST00000264811.5	-	1	919	c.501G>A	c.(499-501)gcG>gcA	p.A167A	TRPC3_ENST00000379645.3_Silent_p.A240A|TRPC3_ENST00000513531.1_Silent_p.A167A	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	155					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GGCAGTGCGCCGCCAGGATGA	0.617000													15	65					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188164	140188164	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140188164G>A	ENST00000530339.1	+	1	1392	c.1392G>A	c.(1390-1392)gtG>gtA	p.V464V	PCDHA4_ENST00000512229.2_Silent_p.V464V|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.V464V|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGTTCGTGAAGGAGAACA	0.642000													36	72					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456549	5456549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5456549C>T	ENST00000222033.4	+	1	1124	c.1047C>T	c.(1045-1047)ccC>ccT	p.P349P		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	349						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GCTCCTGCCCCGTGTGCAAAC	0.642000													13	119					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377318	55377318	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55377318C>T	ENST00000326321.3	+	7	1092	c.1059C>T	c.(1057-1059)atC>atT	p.I353I	KIR3DL2_ENST00000270442.5_Silent_p.I336I|KIR3DL1_ENST00000402254.2_Silent_p.I353I	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	353					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		tcctcttcatcctcctcctct	0.498000													24	58					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179306689	179306689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179306689G>A	ENST00000356834.3	-	8	1392	c.1355C>T	c.(1354-1356)tCc>tTc	p.S452F	TBC1D9B_ENST00000355235.3_Missense_Mutation_p.S452F	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	452						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGGCCCTGGGATGCGGTTGG	0.672000													49	97					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61597340	61597340	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61597340G>A	ENST00000238508.3	+	6	611	c.552G>A	c.(550-552)gtG>gtA	p.V184V		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				TGATTCTGGTGAACGCCCTAT	0.388000													7	91					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818577	159818577	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159818577G>A	ENST00000497452.1	-	0	517																											GGCCCGGACCGGAAGCGGCGC	0.776000													7	23					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	107823108	107823108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:107823108C>T	ENST00000375915.2	-	3	1252	c.1114G>A	c.(1114-1116)Gat>Aat	p.D372N		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	372						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						TCTGGTTCATCATTGGTTAGA	0.443000													16	43					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78444657	78444657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:78444657G>A	ENST00000370767.1	-	1	119	c.32C>T	c.(31-33)tCt>tTt	p.S11F	FUBP1_ENST00000436586.2_Missense_Mutation_p.S11F|FUBP1_ENST00000370768.2_Missense_Mutation_p.S11F			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	11					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						TGAGCCAGAAGAGGGGGGAGG	0.562000			"""F, N"""		oligodendroglioma								16	37					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42607562	42607562	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42607562G>A	ENST00000359486.3	-	1	3886	c.3750C>T	c.(3748-3750)ccC>ccT	p.P1250P	TCF20_ENST00000335626.4_Silent_p.P1250P	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						TCATGATTAAGGGGTTTTGAG	0.463000													6	96					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059153	152059153	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152059153T>C	ENST00000368806.1	-	3	1069	c.1005A>G	c.(1003-1005)gaA>gaG	p.E335E		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	335							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CCTTTCCTGGTTCTTGAGTGT	0.448000													79	310					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55284800	55284800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55284800C>T	ENST00000336077.6	+	3	126	c.86C>T	c.(85-87)cCt>cTt	p.P29L	KIR2DL1_ENST00000291633.7_Missense_Mutation_p.P29L|KIR3DL1_ENST00000541392.1_Intron|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL4_ENST00000396284.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	29					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		CACAGAAAACCTTCCCTCCTG	0.507000													13	121					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44151644	44151644	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44151644C>T	ENST00000223357.3	+	16	2337	c.2032C>T	c.(2032-2034)Cag>Tag	p.Q678*	AEBP1_ENST00000450684.2_Nonsense_Mutation_p.Q253*	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	678	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						GGTGGCAGCGCAGATGGTGGG	0.657000													16	28					0	0	1	0	0
MAP7	9053	broad.mit.edu	37	6	136709639	136709639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136709639C>T	ENST00000354570.3	-	5	828	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	MAP7_ENST00000454590.1_Missense_Mutation_p.E162K|MAP7_ENST00000432797.2_5'UTR|MAP7_ENST00000544465.1_Missense_Mutation_p.E125K|MAP7_ENST00000438100.2_Missense_Mutation_p.E162K	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	140					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		ACAACAGCTTCGTGGCGTTCC	0.493000													33	66					0	0	1	0	0
A4GALT	53947	broad.mit.edu	37	22	43089247	43089247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43089247G>A	ENST00000401850.1	-	2	1200	c.711C>T	c.(709-711)ttC>ttT	p.F237F	A4GALT_ENST00000249005.2_Silent_p.F237F|A4GALT_ENST00000381278.3_Silent_p.F237F			Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	237					glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			NS(1)|central_nervous_system(2)|large_intestine(6)|skin(1)|urinary_tract(1)	11						AGTGGTCCACGAAGTCCCGCA	0.657000													7	23					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113544905	113544905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113544905C>T	ENST00000546530.1	-	16	1942	c.1657G>A	c.(1657-1659)Gaa>Aaa	p.E553K	RASAL1_ENST00000261729.5_Missense_Mutation_p.E552K|RASAL1_ENST00000548055.1_Missense_Mutation_p.E552K|RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000446861.3_Missense_Mutation_p.E552K	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	551					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						AACTCACCTTCATCCCCATCC	0.597000													23	54					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55224310	55224310	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55224310C>T	ENST00000275493.2	+	9	1268	c.1091C>T	c.(1090-1092)tCc>tTc	p.S364F	EGFR_ENST00000420316.2_Missense_Mutation_p.S364F|EGFR_ENST00000454757.2_Missense_Mutation_p.S311F|EGFR_ENST00000455089.1_Missense_Mutation_p.S319F|EGFR_ENST00000442591.1_Missense_Mutation_p.S364F|EGFR_ENST00000344576.2_Missense_Mutation_p.S364F|EGFR_ENST00000342916.3_Missense_Mutation_p.S364F	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	364					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AACTGCACCTCCATCAGTGGC	0.413000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			17	83					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537102	5537102	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5537102G>A	ENST00000380184.1	-	1	833	c.570C>T	c.(568-570)ttC>ttT	p.F190F	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	190										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		ACTGCCACATGAACTCCATGT	0.473000													66	105					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54610467	54610467	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:54610467C>T	ENST00000302287.3	+	1	450	c.44C>T	c.(43-45)tCc>tTc	p.S15F	VSTM2A_ENST00000407838.3_Missense_Mutation_p.S15F|VSTM2A_ENST00000402026.2_Missense_Mutation_p.S14F|VSTM2A_ENST00000402613.3_Missense_Mutation_p.S15F|VSTM2A_ENST00000404951.1_Missense_Mutation_p.S15F			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	15						extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			GTTTTCTTTTCCGTTTTATAT	0.413000													48	101					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106322213	106322213	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106322213G>A	ENST00000390559.2	-	0	110																											AGAAAGTGATGGAGTCGGGAA	0.597000													5	21					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632215	122632215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122632215C>T	ENST00000195173.4	-	17	2637	c.2334G>A	c.(2332-2334)tgG>tgA	p.W778*	SEMA5B_ENST00000451055.2_Nonsense_Mutation_p.W833*|SEMA5B_ENST00000357599.3_Nonsense_Mutation_p.W779*			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	779					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GCCACGGCGTCCAGGGGGTGT	0.716000													4	9					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66112422	66112422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:66112422G>A	ENST00000503581.1	-	7	1670	c.1133C>T	c.(1132-1134)cCt>cTt	p.P378L	EYS_ENST00000393380.2_Missense_Mutation_p.P378L|EYS_ENST00000370616.2_Missense_Mutation_p.P378L|EYS_ENST00000370618.3_Missense_Mutation_p.P378L|EYS_ENST00000370621.3_Missense_Mutation_p.P378L|EYS_ENST00000342421.5_Missense_Mutation_p.P378L	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	378	EGF-like 5.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						ATTCCTCAAAGGAAATGACTC	0.279000													13	95					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57089547	57089547	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57089547C>T	ENST00000330619.8	+	6	2436	c.1750C>T	c.(1750-1752)Cag>Tag	p.Q584*	ZNF470_ENST00000391709.3_Nonsense_Mutation_p.Q584*|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	584				Q -> P (in Ref. 1; AAS64219).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TGTTCAACATCAGAGACTCCA	0.453000													34	104					0	0	1	0	0
HK1	3098	broad.mit.edu	37	10	71103627	71103627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71103627C>T	ENST00000448642.2	+	7	602	c.213C>T	c.(211-213)ctC>ctT	p.L71L	HK1_ENST00000494253.1_3'UTR|HK1_ENST00000360289.2_Silent_p.L24L|HK1_ENST00000404387.2_Silent_p.L40L|HK1_ENST00000359426.6_Silent_p.L36L|HK1_ENST00000298649.3_Silent_p.L35L			P19367	HXK1_HUMAN	hexokinase 1	36	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						ATGAAACTCTCATAGATATCA	0.502000													58	141					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119750052	119750052	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:119750052G>A	ENST00000541757.1	+	16	1398	c.1018_splice	c.e16+1	p.G340_splice	MARCO_ENST00000327097.4_Splice_Site_p.G418_splice			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	418	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGGTGAAAGAGGTAATCACTA	0.413000													10	45					0	0	1	0	0
TGIF2	60436	broad.mit.edu	37	20	35219337	35219337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35219337C>T	ENST00000373874.2	+	3	416	c.217C>T	c.(217-219)Cgg>Tgg	p.R73W	TGIF2-C20orf24_ENST00000558530.1_Intron|RP5-977B1.11_ENST00000561134.1_RNA|TGIF2_ENST00000373872.4_Missense_Mutation_p.R73W	NM_001199514.1|NM_001199515.1	NP_001186443.1|NP_001186444.1	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	73						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(3)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CATCAATGCCCGGCGGCGGCT	0.522000													41	348					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100118719	100118719	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100118719G>A	ENST00000330710.5	+	2	512	c.414G>A	c.(412-414)ctG>ctA	p.L138L	HHIPL1_ENST00000357223.2_Silent_p.L138L	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	138					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				TCTGGGCGCTGGAGGGCAACC	0.602000													12	58					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25890627	25890627	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:25890627A>T	ENST00000520164.1	-	6	1062	c.525T>A	c.(523-525)acT>acA	p.T175T	EBF2_ENST00000408929.3_Silent_p.T27T	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	175					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GGTCCGATGGAGTCTCATTTC	0.388000													7	119					0	0	1	0	0
DPRX	503834	broad.mit.edu	37	19	54140117	54140117	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54140117C>T	ENST00000376650.1	+	3	502	c.451C>T	c.(451-453)Cat>Tat	p.H151Y		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	151						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		CAGAATAGTCCATTTTGGCTG	0.522000													61	135					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099726	168099726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168099726C>T	ENST00000409195.1	+	9	1913	c.1824C>T	c.(1822-1824)atC>atT	p.I608I	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Silent_p.I608I|XIRP2_ENST00000409273.1_Silent_p.I386I|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	433					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATCAAGAAATCATTGCTGGTG	0.423000													26	82					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230008	21230008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21230008C>T	ENST00000233242.1	-	26	9859	c.9732G>A	c.(9730-9732)agG>agA	p.R3244R		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3244					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTGAAAGGTCCTGGGGAGCT	0.393000													15	49					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167786823	167786823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:167786823G>A	ENST00000397829.4	-	8	982	c.815C>T	c.(814-816)tCc>tTc	p.S272F	TCP10_ENST00000366827.2_Intron	NM_004610.3	NP_004601.3	Q12799	TCP10_HUMAN	t-complex 10	299						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		TATTTCCAGGGAAGATGGTGG	0.488000													6	88					0	0	1	0	0
SRC	6714	broad.mit.edu	37	20	36030030	36030030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36030030G>A	ENST00000373578.2	+	11	1414	c.1065G>A	c.(1063-1065)ggG>ggA	p.G355G	SRC_ENST00000358208.4_Silent_p.G355G|SRC_ENST00000360723.4_Silent_p.G361G|SRC_ENST00000373558.2_Silent_p.G361G|SRC_ENST00000477066.1_3'UTR|SRC_ENST00000373567.2_Silent_p.G355G|SRC_ENST00000445403.1_Silent_p.G355G	NM_198291.1	NP_938033.1	P12931	SRC_HUMAN	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	355	Protein kinase.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(16)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	TTCTCAAGGGGGAGACAGGCA	0.622000													21	79					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956173	18956173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18956173G>A	ENST00000302797.3	-	1	383	c.159C>T	c.(157-159)ggC>ggT	p.G53G	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	53					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GCATGCGGCAGCCCAGGAGCC	0.562000													61	140					0	0	1	0	0
MYL10	93408	broad.mit.edu	37	7	101256829	101256829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101256829G>A	ENST00000223167.4	-	8	784	c.607C>T	c.(607-609)Ccc>Tcc	p.P203S		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	203	EF-hand 3.					mitochondrion	calcium ion binding	p.P203S(1)		breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						ACATCTGGGGGAAATGCTGCA	0.557000													33	94					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55027359	55027359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:55027359G>A	ENST00000324000.3	+	4	3028	c.994G>A	c.(994-996)Gaa>Aaa	p.E332K		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	332					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CAACACAAGGGAAGATCTTCC	0.463000													19	57					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130282158	130282158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130282158C>T	ENST00000358511.6	+	2	342	c.311C>T	c.(310-312)tCc>tTc	p.S104F	COL6A6_ENST00000453409.2_Missense_Mutation_p.S104F	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	104	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ATTGGCGGGTCCCTGCAGATA	0.493000													9	39					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54647986	54647986	+	Missense_Mutation	SNP	C	C	T	rs138688054	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54647986C>T	ENST00000406403.1	+	6	2004	c.401C>T	c.(400-402)aCg>aTg	p.T134M	CNOT3_ENST00000221232.5_Missense_Mutation_p.T134M|CNOT3_ENST00000358389.3_5'UTR			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	134					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACCATCGACACGCTCAACATG	0.562000													17	28					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124989840	124989840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124989840G>A	ENST00000522917.1	+	10	1260	c.1054G>A	c.(1054-1056)Gga>Aga	p.G352R	FER1L6_ENST00000399018.1_Missense_Mutation_p.G352R	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	352						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CGAACAGGATGGAGACAAAGG	0.473000													12	25					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289451	107289451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107289451G>A	ENST00000277216.3	-	1	39	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						AGTCCCAGAAGAATGAATTCT	0.398000													10	100					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99631479	99631479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99631479C>T	ENST00000324306.6	+	6	1585	c.1351C>T	c.(1351-1353)Cat>Tat	p.H451Y	ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.H415Y|ZKSCAN1_ENST00000535170.1_Missense_Mutation_p.H238Y	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	451					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TCTCATCCTCCATCAGCGCAT	0.512000													81	202					0	0	1	0	0
GPR27	2850	broad.mit.edu	37	3	71803815	71803815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:71803815C>T	ENST00000304411.2	+	1	615	c.615C>T	c.(613-615)ctC>ctT	p.L205L	EIF4E3_ENST00000421769.2_5'UTR	NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	205						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		TCCGCCTGCTCTTCTTCATCC	0.761000													3	11					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394441	164394441	+	Missense_Mutation	SNP	C	C	T	rs147436359		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164394441C>T	ENST00000280605.3	-	1	606	c.446G>A	c.(445-447)cGg>cAg	p.R149Q		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	149						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GCAGAACACCCGGTAGCTGGC	0.532000													20	85					0	0	1	0	0
APOF	319	broad.mit.edu	37	12	56755842	56755842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56755842G>A	ENST00000398189.3	-	2	225	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S	APOF_ENST00000541105.1_Missense_Mutation_p.P32S	NM_001638.2	NP_001629.1	Q13790	APOF_HUMAN	apolipoprotein F	50					cholesterol metabolic process	high-density lipoprotein particle|low-density lipoprotein particle	cholesterol binding|lipid transporter activity|receptor binding			breast(1)|lung(3)|prostate(1)|stomach(1)	6						AAGGACAAGGGAAAGTGCATC	0.517000													23	118					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15734690	15734690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15734690G>A	ENST00000281171.4	+	23	3540	c.3210G>A	c.(3208-3210)gaG>gaA	p.E1070E	PTPRO_ENST00000542557.1_Silent_p.E231E|PTPRO_ENST00000348962.2_Silent_p.E1042E|PTPRO_ENST00000442921.2_Silent_p.E259E|PTPRO_ENST00000445537.2_Silent_p.E259E|PTPRO_ENST00000544244.1_Silent_p.E231E	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	1070	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TGATTTCAGAGGAAGAGCAGG	0.498000													28	60					0	0	1	0	0
DPP7	29952	broad.mit.edu	37	9	140006426	140006426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140006426G>A	ENST00000371579.2	-	10	1110	c.1106C>T	c.(1105-1107)cCg>cTg	p.P369L		NM_013379.2	NP_037511.2	Q9UHL4	DPP2_HUMAN	dipeptidyl-peptidase 7	369						cytoplasmic membrane-bounded vesicle|extracellular region|lysosome	aminopeptidase activity|protein binding|serine-type peptidase activity			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;4.25e-05)|Epithelial(140;0.000633)		GGGCAGGTCCGGGAACATATC	0.667000													6	40					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32972621	32972621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32972621C>T	ENST00000544455.1	+	27	10198	c.9971C>T	c.(9970-9972)cCa>cTa	p.P3324L	BRCA2_ENST00000380152.3_Missense_Mutation_p.P3324L	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3324					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAGATGACTCCATTTAAAAAA	0.383000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			21	53					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24435081	24435081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24435081G>A	ENST00000330966.7	-	2	208	c.46C>T	c.(46-48)Ccc>Tcc	p.P16S	MYOM3_ENST00000329601.7_Missense_Mutation_p.P16S|MYOM3_ENST00000374434.3_Missense_Mutation_p.P16S			Q5VTT5	MYOM3_HUMAN	myomesin 3	16										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		ATGGCCTGGGGGGGCCGGGGG	0.667000													4	5					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11504555	11504555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11504555G>A	ENST00000379237.1	-	15	2766	c.2372C>T	c.(2371-2373)tCa>tTa	p.S791L	USP6NL_ENST00000277575.5_Missense_Mutation_p.S808L	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	791						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						TGCGGCCGGTGAAGCTTTATA	0.532000													40	138					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577496	14577496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14577496C>T	ENST00000544627.1	+	2	991	c.671C>T	c.(670-672)cCt>cTt	p.P224L	ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000536444.1_Missense_Mutation_p.P216L|ATF7IP_ENST00000543189.1_Missense_Mutation_p.P216L|ATF7IP_ENST00000540793.1_Missense_Mutation_p.P216L|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P216L			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	216					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						GAACCGGTCCCTGTTGAACCC	0.522000													39	115					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2290852	2290852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2290852G>A	ENST00000381458.5	+	3	273	c.210G>A	c.(208-210)acG>acA	p.T70T		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	70					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	CGGCCATGACGAAGGCTGTGT	0.532000													32	149					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32037621	32037621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32037621C>T	ENST00000375244.3	-	15	5497	c.5296G>A	c.(5296-5298)Gat>Aat	p.D1766N	TNXB_ENST00000375247.2_Missense_Mutation_p.D1766N			P22105	TENX_HUMAN	tenascin XB	1848	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCAGTATCATCCATAGCACTC	0.602000													9	27					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55277722	55277722	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55277722A>T	ENST00000358193.3	+	6	676	c.622A>T	c.(622-624)Agt>Tgt	p.S208C	C1orf177_ENST00000371273.3_Missense_Mutation_p.S208C	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	208										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						GCTCTAGGGGAGTGGTCTGGG	0.622000													26	124					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38758068	38758068	+	Missense_Mutation	SNP	G	G	A	rs145862170		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38758068G>A	ENST00000359357.3	+	18	2271	c.2017G>A	c.(2017-2019)Gaa>Aaa	p.E673K	DNAH8_ENST00000441566.1_Missense_Mutation_p.E673K|DNAH8_ENST00000449981.2_Missense_Mutation_p.E890K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTTCTAGGTGGAATCTGTGTT	0.353000													19	139					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	77004407	77004407	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:77004407G>A	ENST00000257626.7	-	11	831	c.753C>T	c.(751-753)ccC>ccT	p.P251P		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		ATATGTCCAAGGGTACTTCAA	0.318000													11	40					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46230641	46230641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:46230641C>T	ENST00000334344.6	+	8	1062	c.890C>T	c.(889-891)tCc>tTc	p.S297F	ARID2_ENST00000422737.1_Missense_Mutation_p.S148F|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	297					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AGAAATCTTTCCTTTGAGGAG	0.398000			"""N, S, F"""		hepatocellular carcinoma								45	85					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41000874	41000874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41000874C>T	ENST00000352632.3	+	6	744	c.658C>T	c.(658-660)Cac>Tac	p.H220Y	SPTBN4_ENST00000598249.1_Missense_Mutation_p.H220Y|SPTBN4_ENST00000595535.1_Missense_Mutation_p.H220Y|SPTBN4_ENST00000344104.3_Missense_Mutation_p.H220Y|SPTBN4_ENST00000338932.3_Missense_Mutation_p.H220Y			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	220	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGCCCTCATTCACCGGCACAG	0.572000													21	42					0	0	1	0	0
PRLHR	2834	broad.mit.edu	37	10	120354453	120354453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:120354453G>A	ENST00000239032.2	-	2	442	c.304C>T	c.(304-306)Ctg>Ttg	p.L102L	PRLHR_ENST00000369169.1_Silent_p.L102L	NM_004248.2	NP_004239.1	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	102					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GACAAGGCCAGGTTGCCGATG	0.687000													29	58					0	0	1	0	0
QSER1	79832	broad.mit.edu	37	11	32955532	32955532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:32955532C>T	ENST00000399302.2	+	4	2676	c.2341C>T	c.(2341-2343)Cat>Tat	p.H781Y	QSER1_ENST00000527788.1_Missense_Mutation_p.H542Y	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	781	Gln-rich.									breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					CAATGGTGATCATTCTCAGCA	0.403000													33	108					0	0	1	0	0
ZFP57	346171	broad.mit.edu	37	6	29640975	29640975	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29640975G>A	ENST00000376883.1	-	6	1264	c.853C>T	c.(853-855)Cag>Tag	p.Q285*	ZFP57_ENST00000376881.3_Nonsense_Mutation_p.Q285*|ZFP57_ENST00000488757.1_Nonsense_Mutation_p.Q305*			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	221					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						ATGGGTGTCTGGAATTCAGCC	0.542000													53	132					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874097	36874097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36874097G>A	ENST00000301807.6	-	21	7092	c.5195C>T	c.(5194-5196)tCc>tTc	p.S1732F	TRANK1_ENST00000429976.2_Missense_Mutation_p.S2282F|TRANK1_ENST00000428977.2_Missense_Mutation_p.S1732F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2282					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CAGGTCTGTGGATTCCCGGCG	0.483000													19	42					0	0	1	0	0
NEXN	91624	broad.mit.edu	37	1	78392180	78392180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:78392180G>A	ENST00000330010.8	+	6	676	c.379G>A	c.(379-381)Gat>Aat	p.D127N	NEXN_ENST00000334785.7_Missense_Mutation_p.D191N|NEXN_ENST00000457030.1_Missense_Mutation_p.D177N	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	191	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		GAATTTTGAGGATCTAGAAAA	0.318000													9	97					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069208	6069208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:6069208G>A	ENST00000381095.3	-	2	927	c.300C>T	c.(298-300)atC>atT	p.I100I	NLGN4X_ENST00000469740.1_5'UTR|NLGN4X_ENST00000275857.6_Silent_p.I100I|NLGN4X_ENST00000538097.1_Silent_p.I100I|NLGN4X_ENST00000381093.2_Silent_p.I100I|NLGN4X_ENST00000381092.1_Silent_p.I100I	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	100					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						TAGTATTTCGGATGCCAGTCC	0.572000													24	48					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32012969	32012969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32012969C>T	ENST00000375244.3	-	32	10942	c.10741G>A	c.(10741-10743)Ggc>Agc	p.G3581S	TNXB_ENST00000451343.1_Missense_Mutation_p.G10S|TNXB_ENST00000375247.2_Missense_Mutation_p.G3579S			P22105	TENX_HUMAN	tenascin XB	3626					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCAAAGGGGCCCTGGGCCACG	0.647000													15	40					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795252	142795252	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142795252G>A	ENST00000370498.1	-	2	1179	c.426C>T	c.(424-426)gaC>gaT	p.D142D		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	142										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCAGATGAGTCCAGGTCTT	0.522000													36	215					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155450702	155450702	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155450702C>T	ENST00000461783.3	+	6	1618	c.345C>T	c.(343-345)ggC>ggT	p.G115G	TIAM2_ENST00000318981.5_Silent_p.G115G|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000529824.2_Silent_p.G115G|TIAM2_ENST00000360366.4_Silent_p.G115G|TIAM2_ENST00000456144.1_Silent_p.G115G			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	115					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTGAGAATGGCTTCCACTCTG	0.542000													17	19					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39871124	39871124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39871124G>A	ENST00000502986.2	+	10	1041	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	IDO2_ENST00000389060.4_Missense_Mutation_p.E254K|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	254					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						GCTGATGTATGAAGGAGTTTC	0.483000													18	77					0	0	1	0	0
HSF2BP	11077	broad.mit.edu	37	21	45012194	45012194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45012194G>A	ENST00000291560.2	-	8	1039	c.708C>T	c.(706-708)tcC>tcT	p.S236S	HSF2BP_ENST00000542962.1_Silent_p.S161S	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	236					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		CATTGTATAGGGACATCAGCA	0.418000													21	56					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510379	56510379	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56510379G>A	ENST00000302957.3	-	1	908	c.909C>T	c.(907-909)ctC>ctT	p.L303L		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGCTATAGATGAGAGGGTTGA	0.433000													37	92					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28617510	28617510	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28617510G>A	ENST00000395609.1	-	9	1400	c.642C>T	c.(640-642)tcC>tcT	p.S214S	SULT1A1_ENST00000350842.4_Silent_p.S136S|SULT1A1_ENST00000395607.1_Silent_p.S214S|SULT1A1_ENST00000569554.1_Silent_p.S214S|SULT1A1_ENST00000314752.7_Silent_p.S214S			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	214					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						CCTCTGGCAGGGAGCGCCCCA	0.547000													26	134					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213014	9213014	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9213014C>T	ENST00000305456.2	-	1	968	c.969G>A	c.(967-969)agG>agA	p.R323R		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						CTATGAACTTCCTCAAGGTTC	0.443000													19	60					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2608837	2608837	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2608837C>T	ENST00000155840.5	+	9	1274	c.1166C>T	c.(1165-1167)tCc>tTc	p.S389F	KCNQ1_ENST00000335475.5_Missense_Mutation_p.S262F	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	389					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	AACCCCGACTCCTCCACCTGG	0.642000													46	99					0	0	1	0	0
NIPSNAP1	8508	broad.mit.edu	37	22	29956781	29956781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29956781C>T	ENST00000216121.7	-	8	902	c.648G>A	c.(646-648)gaG>gaA	p.E216E		NM_001202502.1|NM_003634.3	NP_001189431.1|NP_003625.2	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1 (C. elegans)	216								p.?(1)		large_intestine(2)|lung(2)|skin(1)	5						CGCCCACTGCCTCCTGGTTCT	0.557000													51	128					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187509969	187509969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187509969G>A	ENST00000441802.2	-	27	13753	c.13544C>T	c.(13543-13545)cCc>cTc	p.P4515L		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4515					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGGGGCATGGGGTTCTCTACA	0.517000										HNSCC(5;0.00058)			20	57					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45678478	45678478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45678478G>A	ENST00000270172.3	-	6	927	c.444C>T	c.(442-444)tcC>tcT	p.S148S	DNMT3L_ENST00000418993.1_Silent_p.S148S	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	148	ADD.				DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		CGCTTCGGGAGGACGGCAGGC	0.662000													6	26					0	0	1	0	0
OR1L3	26735	broad.mit.edu	37	9	125437455	125437455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125437455G>A	ENST00000304820.2	+	1	141	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						ATTCTCTTGGGACTCTCCTCT	0.423000													37	118					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642421	57642421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57642421G>A	ENST00000254181.4	+	4	2832	c.2378G>A	c.(2377-2379)gGa>gAa	p.G793E	USP29_ENST00000598197.1_Missense_Mutation_p.G793E	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	793					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GACAACCCAGGAAACAAAAAC	0.468000													6	27					0	0	1	0	0
C16orf54	283897	broad.mit.edu	37	16	29755651	29755651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29755651C>T	ENST00000329410.3	-	2	717	c.622G>A	c.(622-624)Gag>Aag	p.E208K		NM_175900.3	NP_787096.2	Q6UWD8	CP054_HUMAN	chromosome 16 open reading frame 54	208						integral to membrane				breast(1)|central_nervous_system(1)|lung(2)|prostate(1)|urinary_tract(1)	6						GAGATCTGCTCCAAGGTGACC	0.667000													5	22					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602719	96602719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96602719C>T	ENST00000371321.3	+	7	1169	c.1087C>T	c.(1087-1089)Ccc>Tcc	p.P363S	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	363					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CGACCTCATCCCCACCAGCCT	0.532000													44	142					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45312480	45312480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45312480G>A	ENST00000313237.5	-	4	394	c.244C>T	c.(244-246)Ctc>Ttc	p.L82F	PHF21B_ENST00000403565.1_5'UTR|PHF21B_ENST00000404079.2_Missense_Mutation_p.L70F|PHF21B_ENST00000447824.3_Missense_Mutation_p.L70F|PHF21B_ENST00000396103.3_Missense_Mutation_p.L82F	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	82							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GCAACGGGGAGGCTGTCTGGA	0.657000													32	53					0	0	1	0	0
HIBCH	26275	broad.mit.edu	37	2	191117026	191117026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:191117026G>A	ENST00000392332.3	-	8	664	c.525C>T	c.(523-525)ttC>ttT	p.F175F	HIBCH_ENST00000359678.5_Silent_p.F175F			Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-CoA hydrolase	175					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding	p.F175L(1)		NS(1)|breast(2)|endometrium(1)|large_intestine(1)|lung(5)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			CCACATCAGGGAACAGTCCTG	0.363000													15	38					0	0	1	0	0
ZNF474	133923	broad.mit.edu	37	5	121488406	121488406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121488406C>T	ENST00000296600.4	+	2	1104	c.721C>T	c.(721-723)Ccc>Tcc	p.P241S	CTC-441N14.2_ENST00000504829.1_RNA|ZNF474_ENST00000514925.1_Intron	NM_207317.1	NP_997200.1	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	241						intracellular	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|stomach(1)	21		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		TATTCATGAGCCCAAATGCCT	0.527000													30	107					0	0	1	0	0
TRBC2	28638	broad.mit.edu	37	7	142499852	142499852	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142499852C>T	ENST00000466254.1	+	0	469																											GGGAAGGCCACCTTGTATGCC	0.557000													13	42					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	66878844	66878844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:66878844C>T	ENST00000544246.1	-	5	4348	c.3657G>A	c.(3655-3657)ctG>ctA	p.L1219L	PCDH9-AS1_ENST00000430861.1_RNA|PCDH9_ENST00000328454.5_Silent_p.L1185L|PCDH9_ENST00000377865.2_Silent_p.L1219L|PCDH9_ENST00000456367.1_Silent_p.L1185L	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1219					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TATAAGACTTCAGATTTGCCA	0.438000													20	65					0	0	1	0	0
TTC39B	158219	broad.mit.edu	37	9	15203859	15203859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:15203859C>T	ENST00000355694.2	-	7	757	c.523G>A	c.(523-525)Gag>Aag	p.E175K	TTC39B_ENST00000297615.5_Missense_Mutation_p.E172K|TTC39B_ENST00000380850.4_Missense_Mutation_p.E241K|TTC39B_ENST00000512701.1_Missense_Mutation_p.E241K|TTC39B_ENST00000507993.1_Missense_Mutation_p.E76K|TTC39B_ENST00000541445.1_Missense_Mutation_p.E175K|TTC39B_ENST00000507285.1_Missense_Mutation_p.E76K	NM_001168339.1|NM_152574.2	NP_001161811.1|NP_689787.2	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	175							binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)	21						AGGAGACACTCGGCATAACAG	0.388000													11	27					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	484774	484774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:484774C>T	ENST00000264938.3	-	5	802	c.793G>A	c.(793-795)Ggg>Agg	p.G265R	SLC9A3_ENST00000514375.1_Missense_Mutation_p.G265R	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	265						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AAGACCACCCCCACCAGCGTG	0.642000													29	66					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124269	142124269	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142124269G>A	ENST00000390376.2	-	0	208																											AGTACCAGCAGCAGCTGAGTA	0.517000													42	174					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161954026	161954026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161954026G>A	ENST00000294794.3	-	8	2115	c.1692C>T	c.(1690-1692)atC>atT	p.I564I	OLFML2B_ENST00000367938.1_Silent_p.I47I|OLFML2B_ENST00000367940.2_Silent_p.I565I	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	564	Olfactomedin-like.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGCCTGTGCCGATCCAGCTGT	0.582000													19	73					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48678422	48678422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48678422C>T	ENST00000352832.5	+	18	4105	c.3733C>T	c.(3733-3735)Ctg>Ttg	p.L1245L	CACNA1G_ENST00000514717.1_Silent_p.L1245L|CACNA1G_ENST00000515765.1_Silent_p.L1268L|CACNA1G_ENST00000510366.1_Silent_p.L1268L|CACNA1G_ENST00000512389.1_Silent_p.L1268L|CACNA1G_ENST00000513964.1_Silent_p.L1268L|CACNA1G_ENST00000513689.2_Silent_p.L1268L|CACNA1G_ENST00000507609.1_Silent_p.L1268L|CACNA1G_ENST00000505165.1_Silent_p.L1268L|CACNA1G_ENST00000507336.1_Silent_p.L1268L|CACNA1G_ENST00000507510.2_Silent_p.L1268L|CACNA1G_ENST00000442258.2_Silent_p.L1245L|CACNA1G_ENST00000514181.1_Silent_p.L1268L|CACNA1G_ENST00000429973.2_Silent_p.L1268L|CACNA1G_ENST00000514079.1_Silent_p.L1268L|CACNA1G_ENST00000515165.1_Silent_p.L1268L|CACNA1G_ENST00000510115.1_Silent_p.L1245L|CACNA1G_ENST00000503485.1_Silent_p.L1268L|CACNA1G_ENST00000358244.5_Silent_p.L1245L|CACNA1G_ENST00000502264.1_Silent_p.L1245L|CACNA1G_ENST00000416767.4_Silent_p.L1268L|CACNA1G_ENST00000359106.5_Silent_p.L1268L|CACNA1G_ENST00000354983.4_Silent_p.L1245L|CACNA1G_ENST00000507896.1_Silent_p.L1268L|CACNA1G_ENST00000515411.1_Silent_p.L1268L|CACNA1G_ENST00000360761.4_Silent_p.L1245L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1268					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTTCCGCCTCCTGTGTCACCG	0.622000													55	87					0	0	1	0	0
SLC45A3	85414	broad.mit.edu	37	1	205632186	205632186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205632186G>A	ENST00000367145.3	-	3	1028	c.733C>T	c.(733-735)Cgg>Tgg	p.R245W		NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	245					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			AAGCGGGCCCGGCATGGACAG	0.716000			T	"""ETV1, ETV5, ELK4, ERG"""	prostate								11	22					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400298	85400298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85400298G>A	ENST00000258888.5	+	6	3102	c.2935G>A	c.(2935-2937)Gag>Aag	p.E979K		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	979					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGATCTGAGGAGGCAGTAGT	0.542000													56	171					0	0	1	0	0
LRRC37BP1	147172	broad.mit.edu	37	17	28958810	28958810	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:28958810C>T	ENST00000412831.1	+	0	38				SMURF2P1_ENST00000578265.1_RNA																							AAGGAGCATTCATGAAGATGT	0.463000													86	109					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50118201	50118201	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50118201G>A	ENST00000281631.5	+	17	1985	c.1827G>A	c.(1825-1827)ctG>ctA	p.L609L	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505554.1_Silent_p.L588L|PARP8_ENST00000503750.2_Silent_p.L567L|PARP8_ENST00000514342.2_Silent_p.L320L|PARP8_ENST00000505697.2_Silent_p.L609L|PARP8_ENST00000514067.2_Silent_p.L567L	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	609						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				TGAAAGCACTGGATAGCATAA	0.323000													43	103					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102509599	102509599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:102509599C>T	ENST00000321521.9	+	21	3025	c.2452C>T	c.(2452-2454)Cgt>Tgt	p.R818C	PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.R818C|PPIP5K2_ENST00000358359.3_Missense_Mutation_p.R818C			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	818					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						ACGTCATGTTCGTACTAGATT	0.333000													21	100					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24576801	24576801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24576801C>T	ENST00000535378.1	-	11	2144	c.1502G>A	c.(1501-1503)gGa>gAa	p.G501E	KIAA0319_ENST00000543707.1_Missense_Mutation_p.G510E|KIAA0319_ENST00000430948.2_Missense_Mutation_p.G465E|KIAA0319_ENST00000378214.3_Missense_Mutation_p.G510E|KIAA0319_ENST00000537886.1_Missense_Mutation_p.G510E	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	510	PKD 2.				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GTTAGTGGCTCCGTCCGAGTC	0.488000													32	314					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081132	152081132	+	Missense_Mutation	SNP	C	C	T	rs71585886		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152081132C>T	ENST00000368804.1	-	2	4560	c.4561G>A	c.(4561-4563)Gaa>Aaa	p.E1521K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1521	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGCTGTTCCTCCTCGAGG	0.607000													25	128					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292792	4292792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4292792C>T	ENST00000301272.2	-	5	698	c.653G>A	c.(652-654)gGc>gAc	p.G218D	TMIGD2_ENST00000600349.1_Missense_Mutation_p.G46D|TMIGD2_ENST00000600114.1_Missense_Mutation_p.G98D|TMIGD2_ENST00000595645.1_Missense_Mutation_p.G214D	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	218						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		AATGCTCTGGCCCCTCTGGTC	0.647000													23	88					0	0	1	0	0
OSBPL8	114882	broad.mit.edu	37	12	76780412	76780412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:76780412G>A	ENST00000261183.3	-	13	1860	c.1381C>T	c.(1381-1383)Cgt>Tgt	p.R461C	OSBPL8_ENST00000393250.4_Missense_Mutation_p.R419C|OSBPL8_ENST00000393249.2_Missense_Mutation_p.R419C	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	461					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						TTCTTCAAACGGAAATAAGGA	0.274000													13	121					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92307812	92307812	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:92307812C>T	ENST00000276609.3	+	4	597	c.358C>T	c.(358-360)Cct>Tct	p.P120S	SLC26A7_ENST00000523719.1_Missense_Mutation_p.P120S|SLC26A7_ENST00000309536.2_Missense_Mutation_p.P120S	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	120						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			ACGGATTGTCCCTCAGAACAT	0.458000													31	89					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059983	152059983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152059983G>A	ENST00000368806.1	-	3	239	c.175C>T	c.(175-177)Ctt>Ttt	p.L59F		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	59	EF-hand.						calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ATATTCAGAAGATTTGAATTT	0.363000													32	48					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21631159	21631159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21631159C>T	ENST00000328843.6	+	14	2662	c.2631C>T	c.(2629-2631)atC>atT	p.I877I	DNAH11_ENST00000409508.3_Silent_p.I877I			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	877	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ACAAGTTAATCCAAGGAGATG	0.443000									Kartagener syndrome				35	74					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29007989	29007989	+	Silent	SNP	C	C	T	rs56405013	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29007989C>T	ENST00000282397.4	-	6	1031	c.780G>A	c.(778-780)acG>acA	p.T260T	FLT1_ENST00000541932.1_Silent_p.T260T|FLT1_ENST00000539099.1_Silent_p.T260T	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	260	Ig-like C2-type 3.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TTTGAACTCTCGTGTTCAAGG	0.433000													40	84					0	0	1	0	0
GNL1	2794	broad.mit.edu	37	6	30521163	30521163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30521163G>A	ENST00000376621.3	-	6	1742	c.772C>T	c.(772-774)Cct>Tct	p.P258S		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	258					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						GGGTCCCGAGGAAAAGAGGTG	0.572000													52	166					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20790154	20790154	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20790154G>A	ENST00000359062.3	+	9	2162	c.2122G>A	c.(2122-2124)Ggc>Agc	p.G708S	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	708					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AAGAAAATGTGGCCGTATTCT	0.338000													9	32					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507732	155507732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155507732C>T	ENST00000302053.3	-	5	927	c.849G>A	c.(847-849)acG>acA	p.T283T	FGA_ENST00000403106.3_Silent_p.T283T	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	283					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TGGGGCTTTCCGTCTCTGATC	0.542000													53	133					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47219479	47219479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47219479G>A	ENST00000300404.2	+	3	537	c.478G>A	c.(478-480)Gac>Aac	p.D160N	B4GALNT2_ENST00000393354.2_Missense_Mutation_p.D100N|B4GALNT2_ENST00000504681.1_Missense_Mutation_p.D74N	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	160					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TGGCCAGAGCGACCTCCCAGC	0.498000													38	100					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	825636	825636	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:825636C>T	ENST00000293892.3	-	5	1124	c.1125G>A	c.(1123-1125)ggG>ggA	p.G375G	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	103					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						TCGGGTCATCCCCACGGCCAC	0.716000													17	13					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3304454	3304454	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3304454C>T	ENST00000219596.1	-	2	653	c.614G>A	c.(613-615)aGa>aAa	p.R205K	MEFV_ENST00000541159.1_Intron|MEFV_ENST00000536379.1_Intron|MEFV_ENST00000339854.4_Intron	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	205					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	GCTGGCGTTTCTGCGCAGCCG	0.756000													10	21					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37354527	37354527	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37354527C>T	ENST00000310758.4	-	4	767		c.e4-1		ELMO1_ENST00000448602.1_Splice_Site|ELMO1_ENST00000442504.1_Splice_Site	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1						actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						AAGAGACCACCTTAAAAATAC	0.343000													7	30					0	0	1	0	0
FEZ2	9637	broad.mit.edu	37	2	36810533	36810533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:36810533G>A	ENST00000379245.4	-	3	503	c.455C>T	c.(454-456)tCc>tTc	p.S152F	FEZ2_ENST00000305852.7_5'UTR|FEZ2_ENST00000405912.3_Missense_Mutation_p.S152F	NM_001042548.1	NP_001036013.1	Q9UHY8	FEZ2_HUMAN	fasciculation and elongation protein zeta 2 (zygin II)	152					axon guidance|signal transduction		protein binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	7		all_hematologic(82;0.21)				ATTAACACAGGAGACGATGAT	0.443000													29	77					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999549	46999549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46999549C>T	ENST00000374314.4	+	1	1624	c.669C>T	c.(667-669)acC>acT	p.T223T	GPRIN2_ENST00000374317.1_Silent_p.T223T			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	223										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						AGCTGGCTACCACCACCTGCC	0.637000													13	39					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55378071	55378071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55378071C>T	ENST00000326321.3	+	9	1286	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	KIR3DL2_ENST00000270442.5_Missense_Mutation_p.P401L|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.P418L	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	418					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		TCTCAGAGGCCCAAGACACCC	0.522000													34	393					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674097	167674097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167674097G>A	ENST00000519204.1	+	26	5908	c.5790G>A	c.(5788-5790)atG>atA	p.M1930I	TENM2_ENST00000545108.1_Missense_Mutation_p.M2050I|TENM2_ENST00000518659.1_Missense_Mutation_p.M2051I|TENM2_ENST00000520394.1_Missense_Mutation_p.M1812I|TENM2_ENST00000403607.2_Missense_Mutation_p.M1875I					teneurin transmembrane protein 2																		TCTTGAAGATGGTCAACCTCC	0.527000													32	72					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56220307	56220307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56220307C>T	ENST00000332836.2	-	9	2974	c.2947G>A	c.(2947-2949)Gaa>Aaa	p.E983K	CTD-2611O12.8_ENST00000596293.1_RNA	NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	983						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ATCTTGTATTCCTCGTCAATC	0.488000													26	83					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158549183	158549183	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158549183G>A	ENST00000368150.1	-	1	506	c.507C>T	c.(505-507)ttC>ttT	p.F169F		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F169F(1)		breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					GAGAGATAAAGAAGCCTGCAG	0.468000													17	35					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56757193	56757193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56757193G>A	ENST00000326855.2	+	1	847	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E269K(1)		breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						TAATTCCCAGGAAAATATGAA	0.353000													30	59					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92844872	92844872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92844872C>T	ENST00000394468.2	-	3	634	c.557G>A	c.(556-558)gGg>gAg	p.G186E	HEPACAM2_ENST00000341723.4_Missense_Mutation_p.G174E|HEPACAM2_ENST00000453812.2_Missense_Mutation_p.G209E|HEPACAM2_ENST00000440868.1_Missense_Mutation_p.G174E	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	186	Ig-like C2-type 1.					integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						GACAGGTCTCCCATTTTTTAG	0.507000													22	81					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111154921	111154921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111154921C>T	ENST00000280325.4	+	3	275	c.128C>T	c.(127-129)cCc>cTc	p.P43L		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	43										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		AAGCCGTTTCCCTGTGAGTCC	0.572000													62	175					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595095	179595095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179595095G>A	ENST00000589042.1	-	62	18256	c.18032C>T	c.(18031-18033)cCc>cTc	p.P6011L	TTN_ENST00000342992.6_Missense_Mutation_p.P4767L|TTN_ENST00000591111.1_Missense_Mutation_p.P5694L|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5694	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAGTAAGGGGGTTCTGAGGT	0.353000													6	16					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53326422	53326422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:53326422C>T	ENST00000395631.2	-	14	1954	c.1738G>A	c.(1738-1740)Ggc>Agc	p.G580S	FERMT2_ENST00000343279.4_Missense_Mutation_p.G587S|FERMT2_ENST00000557255.1_5'UTR|FERMT2_ENST00000553373.1_Missense_Mutation_p.G587S|FERMT2_ENST00000399304.3_Missense_Mutation_p.G587S|FERMT2_ENST00000341590.3_Missense_Mutation_p.G580S			Q96AC1	FERM2_HUMAN	fermitin family member 2	580	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					TCTTTTTTGCCCCCTTGGAAC	0.398000													7	27					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208200648	208200648	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:208200648C>T	ENST00000367033.3	-	32	6382	c.5625G>A	c.(5623-5625)cgG>cgA	p.R1875R	PLXNA2_ENST00000483048.1_5'UTR	NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1875					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GCCGCTGCCGCCGTGCCTGCT	0.547000													29	85					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56467449	56467449	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56467449C>T	ENST00000291971.3	+	3	2096	c.2025C>T	c.(2023-2025)agC>agT	p.S675S	NLRP8_ENST00000590542.1_Silent_p.S675S	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	675						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TCAGCTCCAGCTCCCATCCTG	0.547000													28	78					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540021	94540021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94540021C>T	ENST00000289495.5	+	1	812	c.596C>T	c.(595-597)tCc>tTc	p.S199F	PPP1R9A_ENST00000424654.1_Missense_Mutation_p.S199F|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.S199F|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.S199F|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.S199F|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.S199F	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	199						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GAGGCTGTCTCCCCAACTGTG	0.502000										HNSCC(28;0.073)			17	44					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455863	5455863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5455863G>A	ENST00000222033.4	+	1	438	c.361G>A	c.(361-363)Ggc>Agc	p.G121S		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	121						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GGCGCTGTTCGGCGTCCCCCT	0.687000													18	112					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332550	100332550	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:100332550G>A	ENST00000341853.1	-	0	1641				AC090825.1_ENST00000408584.1_RNA	NR_003260.1																						GGCCGTCGGAGGGACCTCAGC	0.582000													14	132					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11067975	11067975	+	Silent	SNP	C	C	T	rs144261418		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11067975C>T	ENST00000287766.4	+	10	1429	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	SLC6A1_ENST00000536032.1_Silent_p.F158F	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	336					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCGCAGGATTCGTCATCTTCT	0.592000													35	103					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611058	179611058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179611058G>A	ENST00000360870.5	-	46	16291	c.16069C>T	c.(16069-16071)Cca>Tca	p.P5357S	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8870	Ig-like 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCATATTTGGATCTACAAAA	0.333000													26	49					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390946	197390946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197390946C>T	ENST00000367397.1	+	2	989	c.131C>T	c.(130-132)tCa>tTa	p.S44L	CRB1_ENST00000544212.1_Missense_Mutation_p.S144L|CRB1_ENST00000538660.1_Missense_Mutation_p.S663L|CRB1_ENST00000367399.2_Missense_Mutation_p.S551L|CRB1_ENST00000543483.1_Missense_Mutation_p.H293Y|CRB1_ENST00000535699.1_Missense_Mutation_p.S594L|CRB1_ENST00000367400.3_Missense_Mutation_p.S663L			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	663	EGF-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TCTGGCTCATCATTAAATGTC	0.443000													17	162					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189586379	189586379	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189586379C>T	ENST00000264731.3	+	8	1092	c.1003C>T	c.(1003-1005)Ctg>Ttg	p.L335L	TP63_ENST00000392461.3_Silent_p.L241L|TP63_ENST00000418709.2_Silent_p.L335L|TP63_ENST00000449992.1_Silent_p.L156L|TP63_ENST00000437221.1_Silent_p.L241L|TP63_ENST00000320472.5_Silent_p.L335L|TP63_ENST00000392463.2_Silent_p.L241L|TP63_ENST00000392460.3_Silent_p.L335L|TP63_ENST00000456148.1_Silent_p.L241L|TP63_ENST00000382063.4_Silent_p.L250L|TP63_ENST00000354600.5_Silent_p.L241L|TP63_ENST00000440651.2_Silent_p.L335L	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	335					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGGGCAAGTCCTGGGCCGACG	0.488000										HNSCC(45;0.13)			21	58					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68597784	68597784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68597784C>T	ENST00000570495.1	+	5	1386	c.1094C>T	c.(1093-1095)cCc>cTc	p.P365L	ZFP90_ENST00000563169.2_Missense_Mutation_p.P365L|ZFP90_ENST00000398253.2_Missense_Mutation_p.P365L|RP11-615I2.7_ENST00000571720.1_RNA			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	365					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		GGAGAGAAGCCCTTCCAGTGT	0.473000													13	46					0	0	1	0	0
REEP3	221035	broad.mit.edu	37	10	65379552	65379552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:65379552C>T	ENST00000373758.4	+	7	886	c.703C>T	c.(703-705)Cgc>Tgc	p.R235C	REEP3_ENST00000298249.4_Missense_Mutation_p.R220C	NM_001001330.2	NP_001001330.1	Q6NUK4	REEP3_HUMAN	receptor accessory protein 3	235						integral to membrane				endometrium(1)|large_intestine(2)|lung(3)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CACCAAAGGCCGCAAAGAGGT	0.398000													4	12					0	0	1	0	0
TRIM22	10346	broad.mit.edu	37	11	5730807	5730807	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5730807C>T	ENST00000379965.3	+	8	1703	c.1426C>T	c.(1426-1428)Cga>Tga	p.R476*	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	476	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TCGCTTTTCTCGACCTGCTTA	0.473000													53	176					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23543378	23543378	+	Missense_Mutation	SNP	T	T	G	rs1821843		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23543378T>G	ENST00000300619.7	-	4	2608	c.2403A>C	c.(2401-2403)gaA>gaC	p.E801D	ZNF91_ENST00000397082.2_Missense_Mutation_p.E769D|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	801						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGCCACATTCTTCACATTTGT	0.393000													27	106					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157485638	157485638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157485638C>T	ENST00000361835.3	-	16	2995	c.2838G>A	c.(2836-2838)agG>agA	p.R946R	FCRL5_ENST00000461387.1_5'UTR|FCRL5_ENST00000356953.4_Silent_p.R946R	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	946						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TCACCTTGTTCCTGAGATGCC	0.602000													26	55					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36751979	36751979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36751979C>T	ENST00000354618.5	+	4	372	c.148C>T	c.(148-150)Cgt>Tgt	p.R50C	THRAP3_ENST00000469141.2_Missense_Mutation_p.R50C	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	50	Arg-rich.|Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTCTAGGTCTCGTTCCAGATC	0.398000			T	USP6	aneurysmal bone cysts								50	93					0	0	1	0	0
BMP15	9210	broad.mit.edu	37	X	50653837	50653837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50653837C>T	ENST00000252677.3	+	1	54	c.54C>T	c.(52-54)ttC>ttT	p.F18F		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	18					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					TCGTGCTTTTCATGGAACACA	0.493000													5	14					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95719456	95719456	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95719456C>T	ENST00000480546.1	-	0	1841					NR_002319.2																						TGATCTTGCCCTTGGGTTGGA	0.532000													14	26					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60557857	60557857	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60557857C>T	ENST00000308287.1	+	2	145	c.49C>T	c.(49-51)Cca>Tca	p.P17S		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	17						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						TAGGGGGCTCCCATCATGGCA	0.617000													30	86					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111964021	111964021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111964021G>A	ENST00000369732.3	-	8	835	c.780C>T	c.(778-780)atC>atT	p.I260I	OVGP1_ENST00000540696.1_Intron|OVGP1_ENST00000481495.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	260					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CATAGGTGGGGATCCCCATGA	0.512000													32	97					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22846939	22846939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22846939C>T	ENST00000283645.4	+	8	944	c.814C>T	c.(814-816)Cgg>Tgg	p.R272W	TUBGCP5_ENST00000453949.2_Missense_Mutation_p.R272W	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	272					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TCAGGTTATTCGGGAAACCCT	0.353000													17	72					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100378688	100378688	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100378688G>A	ENST00000273352.3	+	14	2247		c.e14+1		GPR128_ENST00000481506.1_Splice_Site|GPR128_ENST00000475887.1_Splice_Site	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						ACCTGACAAGGTAAGATTCCC	0.428000													16	45					0	0	1	0	0
PISD	23761	broad.mit.edu	37	22	32017780	32017780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32017780G>A	ENST00000382151.2	-	4	730	c.311C>T	c.(310-312)cCc>cTc	p.P104L	PISD_ENST00000478893.1_5'UTR|PISD_ENST00000266095.5_Missense_Mutation_p.P104L|PISD_ENST00000439502.2_Missense_Mutation_p.P138L|PISD_ENST00000336566.4_Missense_Mutation_p.P138L|PISD_ENST00000397500.1_Missense_Mutation_p.P104L			Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	138					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(3)|endometrium(2)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12					Phosphatidylserine(DB00144)	GCTGTAGACGGGCCTGCGCAG	0.617000													39	53					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2026852	2026852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2026852G>A	ENST00000262113.4	+	12	1441	c.1300G>A	c.(1300-1302)Gat>Aat	p.D434N	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	434	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GCAGTGCAATGATGCACCGGT	0.428000													45	179					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98039469	98039469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:98039469C>T	ENST00000370192.3	-	11	1286	c.1186G>A	c.(1186-1188)Gtt>Att	p.V396I		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	396					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TTTACTATAACCTTCCGTGGG	0.388000													24	74					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55069580	55069580	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55069580C>T	ENST00000371316.3	+	11	1204	c.1122C>T	c.(1120-1122)ccC>ccT	p.P374P	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000343744.2_Silent_p.P374P	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	374					fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						CAGAGGTGCCCCTCTCCGTCC	0.577000													33	76					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57117373	57117373	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57117373G>A	ENST00000263314.2	+	7	739		c.e7+1			NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3						positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						GGCGCGCACGGTGAGGACCTA	0.637000											OREG0020966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	30					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073281	134073281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:134073281C>T	ENST00000264360.4	+	1	2812	c.1986C>T	c.(1984-1986)gaC>gaT	p.D662D		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	662	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		AGGTGCGCGACCATGGGCAGC	0.726000													6	36					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766120	77766120	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77766120C>T	ENST00000521891.2	+	10	7411	c.6963C>T	c.(6961-6963)ttC>ttT	p.F2321F	ZFHX4_ENST00000455469.2_Silent_p.F2276F|ZFHX4_ENST00000050961.6_Silent_p.F2276F|ZFHX4_ENST00000518282.1_Silent_p.F2295F	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2276						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATGTGGTTTTCCCCAGGATCT	0.393000										HNSCC(33;0.089)			20	41					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124528957	124528957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:124528957C>T	ENST00000408936.3	+	9	1827	c.1645C>T	c.(1645-1647)Cgc>Tgc	p.R549C	DAB2IP_ENST00000309989.1_Missense_Mutation_p.R425C|DAB2IP_ENST00000259371.2_Missense_Mutation_p.R521C			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	549	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						CCGCACTGCCCGCACCCTCAC	0.627000													25	184					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562537	140562537	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140562537G>A	ENST00000361016.2	+	1	1558	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		135					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATGTTCACTGAAAAGGAAAT	0.378000													18	49					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121301912	121301912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121301912G>A	ENST00000297848.3	+	34	4413	c.4143G>A	c.(4141-4143)aaG>aaA	p.K1381K	COL14A1_ENST00000309791.4_Silent_p.K1381K|COL14A1_ENST00000247781.3_Silent_p.K1286K	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1381	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGGTGAGAAGGCAATGAACG	0.438000													36	67					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38768370	38768370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38768370G>A	ENST00000449082.2	-	16	2813	c.2814C>T	c.(2812-2814)ttC>ttT	p.F938F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	938					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGGGCTGGGGGAATGGGCAGG	0.602000													27	83					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18715676	18715676	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18715676G>A	ENST00000433979.1	+	26	3623	c.3507G>A	c.(3505-3507)ttG>ttA	p.L1169L	PIK3C2G_ENST00000266497.5_Silent_p.L1169L|PIK3C2G_ENST00000538779.1_Silent_p.L1210L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1169	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CTGTTAAATTGAATAACTTGA	0.383000													4	18					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177686749	177686749	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:177686749C>T	ENST00000390654.3	-	12	1060		c.e12-1		COL23A1_ENST00000407622.1_Splice_Site	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1							collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CAGGCTCACCCTGGGGGAGGC	0.607000													52	165					0	0	1	0	0
IFI27L1	122509	broad.mit.edu	37	14	94563264	94563264	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94563264C>T	ENST00000553664.1	+	3	173	c.48C>T	c.(46-48)caC>caT	p.H16H	IFI27L1_ENST00000557066.1_5'UTR|IFI27L1_ENST00000557218.1_5'UTR|IFI27L1_ENST00000554544.1_5'UTR|IFI27L1_ENST00000553350.1_3'UTR|IFI27L1_ENST00000393115.3_5'UTR|IFI27L1_ENST00000556381.1_5'UTR|IFI27L1_ENST00000554562.1_5'UTR|IFI27L1_ENST00000555523.1_5'UTR			Q96BM0	I27L1_HUMAN	interferon, alpha-inducible protein 27-like 1	0						integral to membrane				lung(2)	2						TGGAGGCTCACCGAGGCGAAG	0.507000													6	19					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133502261	133502261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:133502261C>T	ENST00000253861.4	+	11	1727	c.1698C>T	c.(1696-1698)acC>acT	p.T566T	EXOC4_ENST00000460346.1_3'UTR|EXOC4_ENST00000539845.1_Silent_p.T465T|EXOC4_ENST00000545148.1_Silent_p.T176T	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	566					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				ACGCAGACACCATGAAGGTGC	0.413000													9	45					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40033909	40033909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40033909G>A	ENST00000373233.3	-	37	7649	c.7472C>T	c.(7471-7473)cCc>cTc	p.P2491L	CHD6_ENST00000480022.1_5'UTR	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2491					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CCCGGTGAGGGGGATGCCTGG	0.562000													8	91					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143027960	143027960	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143027960C>T	ENST00000343257.2	+	8	1036	c.949C>T	c.(949-951)Cga>Tga	p.R317*	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	317			R -> Q (in THD).		muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CTTTGTGTTTCGAGTGCTGGC	0.517000													38	88					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21157582	21157582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21157582G>A	ENST00000255882.6	-	13	1574	c.1488C>T	c.(1486-1488)ttC>ttT	p.F496F	PI4KA_ENST00000572273.1_Silent_p.F438F	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	438					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCACCACCGGGAACCTCTCGC	0.587000													27	67					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138169253	138169253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:138169253G>A	ENST00000409968.1	+	14	2948	c.2770G>A	c.(2770-2772)Gat>Aat	p.D924N	THSD7B_ENST00000272643.3_Missense_Mutation_p.D924N|THSD7B_ENST00000413152.2_Missense_Mutation_p.D893N|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATGTCCTTGTGATGAATTTAT	0.453000													48	87					0	0	1	0	0
NCAPH	23397	broad.mit.edu	37	2	97033013	97033013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97033013C>T	ENST00000455200.1	+	15	2162	c.1867C>T	c.(1867-1869)Cac>Tac	p.H623Y	NCAPH_ENST00000427946.1_Missense_Mutation_p.H498Y|NCAPH_ENST00000240423.4_Missense_Mutation_p.H634Y			Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	634					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(717;0.0221)				AATTGAAATTCACTATGCCAA	0.388000													35	87					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121747930	121747930	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:121747930G>A	ENST00000452319.1	+	14	4500	c.4440G>A	c.(4438-4440)caG>caA	p.Q1480Q	GLI2_ENST00000361492.4_Silent_p.Q1480Q|GLI2_ENST00000314490.11_Intron			P10070	GLI2_HUMAN	GLI family zinc finger 2	1480					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				AGGCCTGTCAGGACAGCATCC	0.632000													34	100					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34002691	34002691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34002691C>T	ENST00000373381.4	-	62	9986	c.9810G>A	c.(9808-9810)ccG>ccA	p.P3270P		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3126						integral to membrane|plasma membrane	protein binding	p.P3126P(1)		NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGTCAGGGTCGGATCTGGAT	0.517000													23	57					0	0	1	0	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727181	25727181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25727181C>T	ENST00000274764.2	+	1	45	c.45C>T	c.(43-45)ggC>ggT	p.G15G		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	15					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						CCAAGAAGGGCTTTAAGAAAG	0.453000													30	77					0	0	1	0	0
GPR114	221188	broad.mit.edu	37	16	57604336	57604336	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57604336C>T	ENST00000340339.4	+	10	1620	c.1097C>T	c.(1096-1098)cCa>cTa	p.P366L	GPR114_ENST00000394361.4_Intron|GPR114_ENST00000349457.3_Missense_Mutation_p.P366L	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	366					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						TCAGGGGCCCCAGCCCTCCTG	0.627000													14	57					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769732	57769732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57769732G>A	ENST00000371030.2	+	1	3658	c.3658G>A	c.(3658-3660)Ggt>Agt	p.G1220S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1220						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CCGAGATGAGGGTCCCAATGG	0.627000													11	19					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204950989	204950989	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204950989G>A	ENST00000367172.4	+	21	2639	c.2311G>A	c.(2311-2313)Gag>Aag	p.E771K	NFASC_ENST00000513543.1_Missense_Mutation_p.E767K|NFASC_ENST00000338586.6_Missense_Mutation_p.E771K|NFASC_ENST00000367169.4_Missense_Mutation_p.E771K|NFASC_ENST00000360049.4_Missense_Mutation_p.E767K|NFASC_ENST00000367171.4_Missense_Mutation_p.E756K|NFASC_ENST00000401399.1_Missense_Mutation_p.E771K|NFASC_ENST00000539706.1_Missense_Mutation_p.E767K|NFASC_ENST00000367170.4_Missense_Mutation_p.E771K|NFASC_ENST00000339876.6_Missense_Mutation_p.E771K|NFASC_ENST00000404907.1_Missense_Mutation_p.E767K|NFASC_ENST00000404076.1_Missense_Mutation_p.E750K|NFASC_ENST00000338515.6_Missense_Mutation_p.E771K			O94856	NFASC_HUMAN	neurofascin	771	Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GAGGCGGAGAGAGACTCGAGA	0.622000													18	53					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65141095	65141095	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:65141095G>A	ENST00000371073.2	+	20	2739	c.2739G>A	c.(2737-2739)acG>acA	p.T913T	CACHD1_ENST00000290039.5_Silent_p.T862T|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	913					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GGGATTTGACGAACCTTGTGC	0.468000											OREG0013544	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	73					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6750959	6750959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6750959C>T	ENST00000378827.4	+	2	1405	c.186C>T	c.(184-186)ggC>ggT	p.G62G		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	62					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GCATGTTCGGCCTGAAACAGA	0.682000													7	27					0	0	1	0	0
LOC647264	647264	broad.mit.edu	37	13	64321066	64321066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:64321066G>A	ENST00000453638.2	+	1	133	c.133G>A	c.(133-135)Ggc>Agc	p.G45S																	endometrium(2)|lung(1)|urinary_tract(1)	4						ctgtggctatggctgtggcta	0.557000													11	29					0	0	1	0	0
AZU1	566	broad.mit.edu	37	19	828354	828354	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:828354C>T	ENST00000233997.2	+	2	204	c.183C>T	c.(181-183)ttC>ttT	p.F61F		NM_001700.3	NP_001691.1	P20160	CAP7_HUMAN	azurocidin 1	61	Hydrophobic.|Peptidase S1.|Possesses antibiotic activity.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			NS(1)|endometrium(1)|kidney(1)|lung(4)|pancreas(1)|upper_aerodigestive_tract(2)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGCCCGCTTCGTGATGACCG	0.672000													17	82					0	0	1	0	0
HBG2	3048	broad.mit.edu	37	11	5275656	5275656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5275656C>T	ENST00000380259.2	-	7	1421	c.181G>A	c.(181-183)Gtc>Atc	p.V61I	HBG2_ENST00000380252.1_Missense_Mutation_p.V51I|HBG2_ENST00000336906.4_Missense_Mutation_p.V61I					hemoglobin, gamma G											endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	13		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTGCCTTGACTTTGGGGTTG	0.537000													27	102					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117232173	117232173	+	Missense_Mutation	SNP	C	C	T	rs143723757		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117232173C>T	ENST00000332958.2	+	7	764	c.748C>T	c.(748-750)Ctt>Ttt	p.L250F	RFX6_ENST00000471966.1_3'UTR	NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	250					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						CGCTCAACACCTTGTATACCA	0.373000													28	82					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62658387	62658387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62658387C>T	ENST00000535781.1	+	15	2072	c.1961C>T	c.(1960-1962)gCc>gTc	p.A654V	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	694					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					ATCAGGGCAGCCCAAGATCTG	0.572000													27	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179393620	179393620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179393620C>T	ENST00000589042.1	-	360	107082	c.106858G>A	c.(106858-106860)Gaa>Aaa	p.E35620K	TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E33052K|TTN-AS1_ENST00000587944.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E33979K|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E26747K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E26680K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E26555K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	33979							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTGACCTTCGTTTATGCTC	0.418000													22	47					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497306	1497306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1497306C>T	ENST00000421627.2	+	2	581	c.447C>T	c.(445-447)atC>atT	p.I149I		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	228					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CCGGGCGGATCCGCCACCTGG	0.687000													3	10					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206166389	206166389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206166389G>A	ENST00000406610.2	+	18	2801	c.2594G>A	c.(2593-2595)aGg>aAg	p.R865K	PARD3B_ENST00000351153.1_Missense_Mutation_p.R796K|PARD3B_ENST00000462231.1_Missense_Mutation_p.R865K|PARD3B_ENST00000349953.3_Missense_Mutation_p.R865K|PARD3B_ENST00000358768.2_Missense_Mutation_p.R803K	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	865	Lys-rich.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		gatccagaaaggaaaataaag	0.418000													12	29					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65811104	65811104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65811104G>A	ENST00000312006.4	-	3	451	c.170C>T	c.(169-171)tCg>tTg	p.S57L	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.S57L	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	57					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GCGCGGCGGCGAGTTCCGCAG	0.652000													12	33					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1893043	1893043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1893043C>T	ENST00000399161.2	-	16	3237	c.2490G>A	c.(2488-2490)agG>agA	p.R830R	MYT1L_ENST00000428368.2_Silent_p.R828R	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	830					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CCTCGTCTATCCTCCGGGGTT	0.537000													24	72					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20525740	20525740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20525740C>T	ENST00000504154.1	+	14	1630	c.1378C>T	c.(1378-1380)Ccc>Tcc	p.P460S	SLIT2_ENST00000273739.5_Missense_Mutation_p.P464S|SLIT2_ENST00000503823.1_Missense_Mutation_p.P460S|SLIT2_ENST00000503837.1_Missense_Mutation_p.P464S	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	460	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TTGCACCAGCCCCCGCCGCCT	0.488000													47	198					0	0	1	0	0
FAAH	2166	broad.mit.edu	37	1	46871292	46871292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46871292C>T	ENST00000243167.8	+	5	695	c.611C>T	c.(610-612)aCc>aTc	p.T204I	FAAH_ENST00000493735.1_3'UTR	NM_001441.2	NP_001432.2	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	204					fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	22	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	TTTGGCCAGACCGTGAACCCA	0.662000													46	171					0	0	1	0	0
FBLIM1	54751	broad.mit.edu	37	1	16091602	16091602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16091602C>T	ENST00000375766.3	+	3	764	c.124C>T	c.(124-126)Ccc>Tcc	p.P42S	FBLIM1_ENST00000441801.2_Missense_Mutation_p.P42S|FBLIM1_ENST00000400773.1_Missense_Mutation_p.P42S|FBLIM1_ENST00000375771.1_Missense_Mutation_p.P42S|FBLIM1_ENST00000332305.5_Missense_Mutation_p.P42S	NM_017556.2	NP_060026.2	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	42	Filamin-binding.|Pro-rich.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		GCGTGGCCGCCCCTGGGAGGC	0.706000													25	51					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31355448	31355448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:31355448G>A	ENST00000542188.1	-	7	1202	c.889C>T	c.(889-891)Cct>Tct	p.P297S	TRPM1_ENST00000397795.2_Missense_Mutation_p.P258S|TRPM1_ENST00000256552.6_Missense_Mutation_p.P280S	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	258					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		ACCACGTTAGGGCCCCCCTCC	0.612000													41	108					0	0	1	0	0
ADAM33	80332	broad.mit.edu	37	20	3654066	3654066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3654066G>A	ENST00000356518.2	-	11	1309	c.1068C>T	c.(1066-1068)gaC>gaT	p.D356D	ADAM33_ENST00000466620.1_5'UTR|ADAM33_ENST00000350009.2_Silent_p.D356D|ADAM33_ENST00000379861.4_Silent_p.D356D	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	356	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						AGCCGTCGGGGTCGTGGCTGA	0.766000													5	5					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104312939	104312939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104312939C>T	ENST00000389120.3	+	10	1234	c.1144C>T	c.(1144-1146)Cgc>Tgc	p.R382C		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	382					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		TCCAGAATATCGCTGCATGCA	0.507000													83	124					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85566375	85566375	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85566375G>A	ENST00000295887.5	+	12	1576	c.1152_splice	c.e12-1	p.D385_splice		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	385					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GTTTCTAAAGGATTTTGCAAA	0.338000													23	63					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039377	11039377	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039377C>T	ENST00000470054.1	-	0	826									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAGACATTTTCATTTCTTCAC	0.338000													28	311					0	0	1	0	0
RRH	10692	broad.mit.edu	37	4	110763652	110763652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110763652C>T	ENST00000317735.4	+	6	782	c.748C>T	c.(748-750)Ctg>Ttg	p.L250L		NM_006583.2	NP_006574.1	O14718	OPSX_HUMAN	retinal pigment epithelium-derived rhodopsin homolog	250					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	12		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		CTGCATGTTTCTGGTGGCATG	0.398000													39	135					0	0	1	0	0
CYBRD1	79901	broad.mit.edu	37	2	172409859	172409859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:172409859C>T	ENST00000321348.4	+	3	604	c.406C>T	c.(406-408)Ctt>Ttt	p.L136F	CYBRD1_ENST00000409484.1_Missense_Mutation_p.L78F|CYBRD1_ENST00000375252.3_Missense_Mutation_p.S66F	NM_024843.3	NP_079119.3	Q53TN4	CYBR1_HUMAN	cytochrome b reductase 1	136	Cytochrome b561.				cellular iron ion homeostasis|electron transport chain|transmembrane transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|liver(2)|lung(3)	10						TGTTTAGCTTCTTTCAGGTTT	0.328000													22	70					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904769	55904769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55904769G>A	ENST00000301529.1	-	1	425	c.426C>T	c.(424-426)ctC>ctT	p.L142L		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					ACACCAGCAGGAGGCAGAGCC	0.473000													25	108					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579753	44579753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44579753G>A	ENST00000289547.4	-	2	298	c.243C>T	c.(241-243)ctC>ctT	p.L81L	NPC1L1_ENST00000546276.1_Silent_p.L81L|NPC1L1_ENST00000423141.1_Silent_p.L81L|NPC1L1_ENST00000381160.3_Silent_p.L81L	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	81					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GGCCGGTGTAGAGGCGGGGGC	0.612000													12	31					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116758449	116758449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116758449C>T	ENST00000331677.3	+	7	3262	c.2818C>T	c.(2818-2820)Ctc>Ttc	p.L940F	DSE_ENST00000537543.1_Missense_Mutation_p.L959F|DSE_ENST00000452085.3_Missense_Mutation_p.L940F|DSE_ENST00000359564.2_Missense_Mutation_p.L940F			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	940					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TGCAGTTCTTCTCATAGATAG	0.388000													18	56					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21251345	21251345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21251345G>A	ENST00000233242.1	-	13	1810	c.1683C>T	c.(1681-1683)gcC>gcT	p.A561A	APOB_ENST00000399256.4_Silent_p.A561A	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	561	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACATAAGATAGGCAGCCAGTC	0.443000													23	130					0	0	1	0	0
SNX15	29907	broad.mit.edu	37	11	64803081	64803081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64803081C>T	ENST00000377244.3	+	6	740	c.610C>T	c.(610-612)Cga>Tga	p.R204*	SNX15_ENST00000301886.3_3'UTR	NM_013306.4|NM_147777.3	NP_037438.2|NP_680086.2	Q9NRS6	SNX15_HUMAN	sorting nexin 15	204					cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14						TTCCCCTGCCCGAGGCCCCCT	0.637000													54	147					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24581180	24581180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24581180C>T	ENST00000535378.1	-	8	1868	c.1226G>A	c.(1225-1227)gGa>gAa	p.G409E	KIAA0319_ENST00000543707.1_Missense_Mutation_p.G418E|KIAA0319_ENST00000430948.2_Missense_Mutation_p.G373E|KIAA0319_ENST00000378214.3_Missense_Mutation_p.G418E|KIAA0319_ENST00000537886.1_Missense_Mutation_p.G418E	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	418	PKD 1.				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						ATTGACAAATCCTTCTCCAAA	0.393000											OREG0017229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	139					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117243663	117243663	+	Missense_Mutation	SNP	C	C	T	rs121909034	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117243663C>T	ENST00000003084.6	+	17	2867	c.2735C>T	c.(2734-2736)tCg>tTg	p.S912L	CFTR_ENST00000454343.1_Missense_Mutation_p.S851L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	912	ABC transmembrane type-1 2.		S -> L.		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AGCACCAGTTCGTATTATGTG	0.418000									Cystic Fibrosis				9	109					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12955431	12955431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12955431C>T	ENST00000235347.4	-	2	327	c.248G>A	c.(247-249)aGg>aAg	p.R83K		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	83										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATCAAGTCCCCTCAGGACAGC	0.612000													17	47					0	0	1	0	0
LYZL4	131375	broad.mit.edu	37	3	42445550	42445550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42445550C>T	ENST00000287748.3	-	4	634	c.359G>A	c.(358-360)gGg>gAg	p.G120E	LYZL4_ENST00000470991.1_5'UTR|LYZL4_ENST00000441172.1_Missense_Mutation_p.G120E	NM_144634.2	NP_653235.1	Q96KX0	LYZL4_HUMAN	lysozyme-like 4	120					cell wall macromolecule catabolic process	extracellular region	lysozyme activity	p.G120V(1)		central_nervous_system(1)|endometrium(1)|lung(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.222)		TGCTCCCATCCCTTCTTTTCC	0.383000													17	47					0	0	1	0	0
NUDT21	11051	broad.mit.edu	37	16	56480599	56480599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56480599G>A	ENST00000300291.5	-	3	492	c.320C>T	c.(319-321)cCt>cTt	p.P107L		NM_007006.2	NP_008937.1	O43809	CPSF5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 21	107	Necessary for RNA-binding.|Necessary for interactions with PAPOLA and PABPN1.|Nudix hydrolase.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	centrosome|mRNA cleavage factor complex|paraspeckles	AU-rich element binding|histone deacetylase binding|hydrolase activity|mRNA binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)	7						TTCACCACCAGGTCTGTATAA	0.318000													9	68					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	109001422	109001422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:109001422C>T	ENST00000276659.5	-	3	765	c.145G>A	c.(145-147)Gac>Aac	p.D49N	RSPO2_ENST00000378439.2_Intron|RSPO2_ENST00000517939.1_5'UTR|RSPO2_ENST00000517781.1_Intron	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	49					Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CACCCATTGTCCTTTGAACAA	0.403000													22	55					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121942283	121942283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121942283G>A	ENST00000442488.2	-	4	1263	c.1196C>T	c.(1195-1197)cCt>cTt	p.P399L	FEZF1_ENST00000331178.4_Missense_Mutation_p.P395L|FEZF1_ENST00000427185.2_Missense_Mutation_p.P349L	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	399					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						GCAGGTGAAAGGCTTCTTGTC	0.567000													9	181					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151123530	151123530	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151123530G>A	ENST00000370328.3	-	9	1217	c.1164C>T	c.(1162-1164)gcC>gcT	p.A388A	GABRE_ENST00000483564.1_5'UTR|GABRE_ENST00000370325.1_3'UTR	NM_004961.3	NP_004952.2	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	388					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CACGGGTACGGGCATGGGCAC	0.542000													3	6					0	0	1	0	0
CD276	80381	broad.mit.edu	37	15	73996202	73996202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73996202C>T	ENST00000318443.5	+	5	1238	c.936C>T	c.(934-936)gcC>gcT	p.A312A	CD276_ENST00000537340.2_Silent_p.A166A|CD276_ENST00000564751.1_Intron|CD276_ENST00000318424.5_Intron|CD276_ENST00000561213.1_Silent_p.A312A	NM_001024736.1	NP_001019907.1	Q5ZPR3	CD276_HUMAN	CD276 molecule	312	Ig-like V-type 2.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						ACCGCACGGCCCTCTTCCCGG	0.642000													17	55					0	0	1	0	0
KCNJ14	3770	broad.mit.edu	37	19	48967571	48967571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48967571C>T	ENST00000391884.1	+	2	1324	c.848C>T	c.(847-849)cCt>cTt	p.P283L	KCNJ14_ENST00000342291.2_Missense_Mutation_p.P283L			Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 14	283						voltage-gated potassium channel complex	inward rectifier potassium channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(2)|urinary_tract(1)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		TCTGCCAGTCCTCTGTATGAG	0.577000													7	12					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238725807	238725807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238725807C>T	ENST00000316997.4	+	3	380	c.248C>T	c.(247-249)tCa>tTa	p.S83L	RBM44_ENST00000444524.2_Intron|RBM44_ENST00000409864.1_Missense_Mutation_p.S83L	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	82							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		CCATTTTTTTCAGTGAGTCAA	0.333000													28	61					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286115	48286115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48286115C>T	ENST00000320048.1	+	1	703	c.703C>T	c.(703-705)Ctc>Ttc	p.L235F		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GCACAAGGCCCTCTCCACCTG	0.537000													44	40					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123695634	123695634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:123695634C>T	ENST00000422452.2	-	14	2384	c.2321G>A	c.(2320-2322)cGa>cAa	p.R774Q	TENM1_ENST00000371130.3_Missense_Mutation_p.R774Q	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1									p.R776Q(1)									CAGGGTACATCGTCCATTTCC	0.473000													40	28					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97143773	97143773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97143773G>A	ENST00000371247.2	-	17	1696	c.1507C>T	c.(1507-1509)Cgc>Tgc	p.R503C	SORBS1_ENST00000277982.5_Missense_Mutation_p.R525C|SORBS1_ENST00000306402.6_Missense_Mutation_p.R334C|SORBS1_ENST00000361941.3_Missense_Mutation_p.R503C|SORBS1_ENST00000607232.1_Missense_Mutation_p.R292C|SORBS1_ENST00000371241.1_Missense_Mutation_p.R293C|SORBS1_ENST00000347291.4_Missense_Mutation_p.R371C|SORBS1_ENST00000354106.3_Missense_Mutation_p.R473C|SORBS1_ENST00000371245.3_Missense_Mutation_p.R388C|SORBS1_ENST00000371246.2_Missense_Mutation_p.R525C|SORBS1_ENST00000371227.4_Missense_Mutation_p.R457C|SORBS1_ENST00000371239.1_Missense_Mutation_p.R302C|SORBS1_ENST00000353505.5_Missense_Mutation_p.R388C|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000371249.2_Missense_Mutation_p.R425C|SORBS1_ENST00000393949.1_Missense_Mutation_p.R473C			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	503					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GAGGAAGAGCGGGCTGGGAGG	0.517000													33	87					0	0	1	0	0
ANKRD30BP3	338579	broad.mit.edu	37	10	45652289	45652289	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45652289C>T	ENST00000427229.2	+	0	1803																											CCTGACATGGCTGAAAGCTTG	0.473000													10	34					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69472590	69472590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69472590C>T	ENST00000303714.4	+	18	1990	c.1668C>T	c.(1666-1668)tcC>tcT	p.S556S		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	556	Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						ctcctccctcccgccctcctc	0.622000									Familial Infantile Hemangioma				7	43					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109859092	109859092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109859092C>T	ENST00000356711.2	+	35	5611	c.5485C>T	c.(5485-5487)Cca>Tca	p.P1829S	MYO16_ENST00000357550.2_Missense_Mutation_p.P1829S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1829					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GGTGCCTCCCCCACCACCTTG	0.607000													4	58					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134183896	134183896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:134183896G>A	ENST00000431683.2	+	17	1641	c.1641G>A	c.(1639-1641)ctG>ctA	p.L547L		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	547					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TCTATTCCCTGGAGATGAAAA	0.483000													4	20					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92470044	92470044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92470044C>T	ENST00000370389.2	+	17	3167	c.2243C>T	c.(2242-2244)tCc>tTc	p.S748F	BRDT_ENST00000394530.3_Missense_Mutation_p.S775F|BRDT_ENST00000362005.3_Missense_Mutation_p.S821F|BRDT_ENST00000402388.1_Missense_Mutation_p.S821F|BRDT_ENST00000399546.2_Missense_Mutation_p.S821F	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	821					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GTAATGAAATCCTCAGATGAG	0.358000													43	104					0	0	1	0	0
SLC37A1	54020	broad.mit.edu	37	21	43982259	43982259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43982259C>T	ENST00000352133.2	+	12	2035	c.1053C>T	c.(1051-1053)ccC>ccT	p.P351P	SLC37A1_ENST00000398341.3_Silent_p.P351P			P57057	GLPT_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 1	351					carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						TCTGGCTGCCCCTGTACATCA	0.507000													30	106					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44560656	44560656	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44560656C>T	ENST00000289547.4	-	13	3070	c.3015G>A	c.(3013-3015)gtG>gtA	p.V1005V	NPC1L1_ENST00000381160.3_Silent_p.V1005V|NPC1L1_ENST00000546276.1_Silent_p.V959V	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1005					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GGAACTGCTCCACCGAGGGCC	0.567000													45	163					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563900	176563900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176563900G>A	ENST00000367662.3	+	3	2324	c.1160G>A	c.(1159-1161)aGc>aAc	p.S387N	PAPPA2_ENST00000367661.3_Missense_Mutation_p.S387N	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	387					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CAGGTGGCTAGCAGTCTAGAC	0.577000													25	62					0	0	1	0	0
RHOH	399	broad.mit.edu	37	4	40245409	40245409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40245409G>A	ENST00000381799.4	+	3	1127	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K	RHOH_ENST00000505618.1_Missense_Mutation_p.E135K	NM_001278363.1|NM_001278365.1|NM_004310.3	NP_001265292.1|NP_001265294.1|NP_004301.1	Q15669	RHOH_HUMAN	ras homolog family member H	135					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			kidney(1)|large_intestine(3)|lung(7)|ovary(1)	12						CAATGCCATGGAAGGGAAGAA	0.612000													20	46					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994983	140994983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140994983G>A	ENST00000285879.4	+	4	2079	c.1793G>A	c.(1792-1794)aGc>aAc	p.S598N	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	598							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCTCAGAGCCCTCCTCAG	0.587000										HNSCC(15;0.026)			215	160					0	0	1	0	0
PSKH2	85481	broad.mit.edu	37	8	87076221	87076221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87076221C>T	ENST00000276616.2	-	2	899	c.825G>A	c.(823-825)ctG>ctA	p.L275L		NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	275	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			ATTTGCCTTTCAGAATCTTCC	0.403000													10	42					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206224524	206224524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206224524C>T	ENST00000367126.4	+	1	549	c.84C>T	c.(82-84)ggC>ggT	p.G28G		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	28					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCTGGCTGGGCCGGGATGAGG	0.672000													88	257					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173352339	173352339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:173352339C>T	ENST00000375221.2	+	17	2545	c.2342C>T	c.(2341-2343)cCt>cTt	p.P781L	ITGA6_ENST00000264106.6_Missense_Mutation_p.P781L|ITGA6_ENST00000409532.1_Missense_Mutation_p.P623L|ITGA6_ENST00000409080.1_Missense_Mutation_p.P742L|AC093818.1_ENST00000442417.1_RNA|ITGA6_ENST00000343713.4_Missense_Mutation_p.P737L|ITGA6_ENST00000264107.7_Missense_Mutation_p.P742L			P23229	ITA6_HUMAN	integrin, alpha 6	781					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CTCGGAAATCCTTTTAAAAGA	0.408000													17	57					0	0	1	0	0
HOMER1	9456	broad.mit.edu	37	5	78672008	78672008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78672008G>A	ENST00000334082.6	-	9	2331	c.889C>T	c.(889-891)Cgg>Tgg	p.R297W	HOMER1_ENST00000282260.6_Missense_Mutation_p.R167W|HOMER1_ENST00000535690.1_Missense_Mutation_p.R123W|HOMER1_ENST00000508576.1_3'UTR	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)	297					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		TCTTTGTTCCGAATTTCTACT	0.368000													43	109					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170037998	170037998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170037998C>T	ENST00000263816.3	-	52	10414	c.10129G>A	c.(10129-10131)Gat>Aat	p.D3377N	LRP2_ENST00000461418.1_5'UTR	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3377					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TAGAGTAGATCATTGGTGTAA	0.418000													22	78					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3265542	3265542	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3265542G>A	ENST00000520002.1	-	15	2508	c.1953C>T	c.(1951-1953)gtC>gtT	p.V651V	CSMD1_ENST00000542608.1_Silent_p.V650V|CSMD1_ENST00000400186.3_Silent_p.V651V|CSMD1_ENST00000602557.1_Silent_p.V651V|CSMD1_ENST00000537824.1_Silent_p.V650V|CSMD1_ENST00000602723.1_Silent_p.V651V|CSMD1_ENST00000539096.1_Silent_p.V650V			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	651	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAGTACCCAGGACAGTTATGT	0.463000													5	36					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37744553	37744553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37744553C>T	ENST00000539465.1	+	16	3117	c.2524C>T	c.(2524-2526)Cta>Tta	p.L842L	FRMPD1_ENST00000377765.3_Silent_p.L842L|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	842						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		AAGGTCTTTCCTACAGACCGA	0.557000													28	52					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94652133	94652133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94652133G>A	ENST00000260526.6	-	16	1884	c.1702C>T	c.(1702-1704)Cca>Tca	p.P568S	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	568					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GGTGTTCGTGGAAGTTTTCGA	0.373000													68	138					0	0	1	0	0
NXPE4	54827	broad.mit.edu	37	11	114451014	114451014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:114451014G>A	ENST00000375478.3	-	5	1119	c.939C>T	c.(937-939)tcC>tcT	p.S313S	NXPE4_ENST00000424261.2_Silent_p.S29S	NM_001077639.1	NP_001071107.1			neurexophilin and PC-esterase domain family, member 4																		TGGGGATTGTGGATGTCATTC	0.413000													29	94					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103061833	103061833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103061833C>T	ENST00000306312.3	-	3	390	c.129G>A	c.(127-129)gcG>gcA	p.A43A	SLC26A5_ENST00000393730.1_Silent_p.A43A|SLC26A5_ENST00000432958.2_Silent_p.A43A|SLC26A5_ENST00000393729.1_Silent_p.A43A|SLC26A5_ENST00000356767.4_Silent_p.A43A|SLC26A5_ENST00000339444.6_Silent_p.A43A|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000393727.1_Silent_p.A43A|SLC26A5_ENST00000393735.2_Silent_p.A43A|SLC26A5_ENST00000393723.1_Silent_p.A43A	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	43					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						TCAGCTTATCCGCAATGGAAT	0.433000													10	49					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18876381	18876381	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18876381G>A	ENST00000447925.2	-	4	494	c.225C>T	c.(223-225)ttC>ttT	p.F75F	PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000435379.1_Intron|PLCZ1_ENST00000266505.7_Silent_p.F77F|RP11-361I14.2_ENST00000536931.1_RNA	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	77					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AATATGTGTTGAAAATCTCAA	0.348000													23	52					0	0	1	0	0
TXLNB	167838	broad.mit.edu	37	6	139564197	139564197	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:139564197G>A	ENST00000358430.3	-	10	1753	c.1521C>T	c.(1519-1521)ttC>ttT	p.F507F	RP1-225E12.3_ENST00000585874.1_RNA	NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	507						cytoplasm		p.F507F(1)		breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		GAATTATCATGAAGGCTGTGG	0.512000													50	122					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31309784	31309784	+	Silent	SNP	C	C	T	rs11542984	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:31309784C>T	ENST00000380490.3	+	1	140	c.42C>T	c.(40-42)atC>atT	p.I14I		NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	14					cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		TGTTGGCCATCGTCACCCTCA	0.517000													15	38					0	0	1	0	0
TFPI	7035	broad.mit.edu	37	2	188349653	188349653	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:188349653C>T	ENST00000233156.3	-	5	714	c.420G>A	c.(418-420)agG>agA	p.R140R	AC007319.1_ENST00000453517.1_RNA|TFPI_ENST00000339091.4_Silent_p.R140R|AC007319.1_ENST00000412276.1_RNA|TFPI_ENST00000409676.1_Silent_p.R140R|TFPI_ENST00000392365.1_Silent_p.R140R	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	140	BPTI/Kunitz inhibitor 2.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	TATAAAAATACCTGGTAATAT	0.343000													7	63					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11078587	11078587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11078587C>T	ENST00000287766.4	+	16	2156	c.1735C>T	c.(1735-1737)Cgc>Tgc	p.R579C	SLC6A1_ENST00000536032.1_Missense_Mutation_p.R401C	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	579					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	AGACATCGTTCGCCCAGAGAA	0.637000													29	72					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164534538	164534538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164534538C>T	ENST00000503008.1	-	5	1146	c.170G>A	c.(169-171)aGc>aAc	p.S57N	MARCH1_ENST00000274056.7_Missense_Mutation_p.S57N|MARCH1_ENST00000514618.1_Missense_Mutation_p.S57N|MARCH1_ENST00000339875.5_Missense_Mutation_p.S40N	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	57	Responsible for low stability (By similarity).				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGTTGTTGGGCTGCTTGCCTG	0.403000													37	84					0	0	1	0	0
REN	5972	broad.mit.edu	37	1	204124159	204124159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204124159G>A	ENST00000367195.2	-	9	1240	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	REN_ENST00000272190.8_Silent_p.F402F			P00797	RENI_HUMAN	renin	402					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGGCCAAGGCGAAGCCAATGC	0.632000													18	49					0	0	1	0	0
GMCL1	64395	broad.mit.edu	37	2	70096880	70096880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70096880C>T	ENST00000282570.3	+	12	1499	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F		NM_178439.3	NP_848526.1	Q96IK5	GMCL1_HUMAN	germ cell-less, spermatogenesis associated 1	416					cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	15						GTTTTAACTTCGGCTTCGACC	0.358000													22	111					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18691869	18691869	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18691869C>T	ENST00000251296.1	+	6	1076	c.693C>T	c.(691-693)ctC>ctT	p.L231L		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	231						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CACTGTCCCTCCTGGACGCCG	0.652000													40	111					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70635117	70635117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70635117G>A	ENST00000381269.2	-	2	776	c.23C>T	c.(22-24)cCt>cTt	p.P8L	SLC8A3_ENST00000528359.1_Missense_Mutation_p.P8L|SLC8A3_ENST00000357887.3_Missense_Mutation_p.P8L|SLC8A3_ENST00000534137.1_Missense_Mutation_p.P8L|SLC8A3_ENST00000356921.2_Missense_Mutation_p.P8L	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	8					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGAGGTGAGAGGCTGCAACCT	0.537000													14	31					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56370026	56370026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56370026G>A	ENST00000301295.6	+	3	1689	c.1267G>A	c.(1267-1269)Ggg>Agg	p.G423R	NLRP4_ENST00000587891.1_Missense_Mutation_p.G348R|NLRP4_ENST00000346986.5_Missense_Mutation_p.G423R	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	423	NACHT.						ATP binding	p.G423W(2)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCGGAGAAATGGGGTTGTTGA	0.562000													53	99					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124253036	124253036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124253036G>A	ENST00000375013.2	-	1	222	c.204C>T	c.(202-204)ttC>ttT	p.F68F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGAGATCAATGAAGGAGAGAT	0.408000													51	142					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108861132	108861132	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:108861132G>A	ENST00000356922.4	-	2	2757	c.2485C>T	c.(2485-2487)Ctg>Ttg	p.L829L	LIG4_ENST00000442234.1_Silent_p.L829L|LIG4_ENST00000405925.1_Silent_p.L829L	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	829	BRCT 2.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TTGGTACTCAGGTCATTAATA	0.428000								Non-homologous end-joining					18	79					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76492029	76492029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76492029C>T	ENST00000389840.5	-	38	5913	c.5789G>A	c.(5788-5790)gGt>gAt	p.G1930D	RP11-559N14.5_ENST00000591373.1_RNA|DNAH17_ENST00000585328.1_Missense_Mutation_p.G1939D					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GATGAAGATACCGACGGTGGG	0.527000													16	59					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149516467	149516467	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149516467C>T	ENST00000378016.2	+	0	11870							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCGTGGGAACCTTGCTCCCGC	0.701000													4	21					0	0	1	0	0
HOXB1	3211	broad.mit.edu	37	17	46608058	46608058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46608058G>A	ENST00000239174.6	-	1	301	c.209C>T	c.(208-210)tCg>tTg	p.S70L	HOXB1_ENST00000577092.1_Missense_Mutation_p.S70L	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	70						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCCCAGGGTCGAAGGCGGCTG	0.682000													16	47					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43400359	43400359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43400359C>T	ENST00000244533.3	+	1	871	c.512C>T	c.(511-513)gCt>gTt	p.A171V	ABCC10_ENST00000443426.2_Intron|ABCC10_ENST00000372530.4_Missense_Mutation_p.A214V	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	214						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CCTGAGGTGGCTGAAGATGGG	0.637000													41	100					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16411595	16411595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:16411595C>T	ENST00000334133.4	-	6	1290	c.1018G>A	c.(1018-1020)Gga>Aga	p.G340R	RFTN1_ENST00000432519.1_Missense_Mutation_p.G304R|RFTN1_ENST00000483671.1_5'UTR	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	340						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						TTCACTATTCCAAGGTAGAAG	0.493000													24	111					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45960781	45960781	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45960781G>A	ENST00000348697.2	+	15	1862	c.1715G>A	c.(1714-1716)gGa>gAa	p.G572E	FBLN1_ENST00000327858.6_Intron|FBLN1_ENST00000442170.2_Missense_Mutation_p.G572E			P23142	FBLN1_HUMAN	fibulin 1	571	EGF-like 9; calcium-binding.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TCCAAGAAGGGAAGGCAGAAC	0.527000													6	76					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177063141	177063141	+	Nonsense_Mutation	SNP	C	C	T	rs142589281		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:177063141C>T	ENST00000393643.2	+	11	1702	c.1450C>T	c.(1450-1452)Cga>Tga	p.R484*	WDR17_ENST00000508596.1_Nonsense_Mutation_p.R484*|WDR17_ENST00000280190.4_Nonsense_Mutation_p.R508*|WDR17_ENST00000507824.2_Nonsense_Mutation_p.R491*	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	508										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TAGTATTATTCGAACAATTGA	0.274000													44	89					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917519	48917519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48917519G>A	ENST00000311378.4	+	2	1398	c.870G>A	c.(868-870)cgG>cgA	p.R290R	WFIKKN2_ENST00000426127.1_Silent_p.R197R|RP11-506D12.5_ENST00000572491.2_RNA	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	290	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCACGGCCCGGAACGTGGCTG	0.622000													19	56					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2017126	2017126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2017126G>A	ENST00000382722.5	-	5	926	c.564C>T	c.(562-564)ctC>ctT	p.L188L	CACNA2D4_ENST00000585708.1_Silent_p.L124L|CACNA2D4_ENST00000587995.1_Silent_p.L188L|CACNA2D4_ENST00000586184.1_Silent_p.L188L|CACNA2D4_ENST00000585732.1_Silent_p.L188L|CACNA2D4_ENST00000588077.1_Silent_p.L124L	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	188						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TGGACTCCAGGAGGAACTCGG	0.597000													8	36					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645340	52645340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:52645340C>T	ENST00000395961.3	-	4	480	c.314G>A	c.(313-315)gGa>gAa	p.G105E	BCAS1_ENST00000371435.2_Missense_Mutation_p.G105E|BCAS1_ENST00000371440.3_Missense_Mutation_p.G105E|BCAS1_ENST00000411563.1_Missense_Mutation_p.G8E	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	105						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TCCGGTACGTCCTGGTACAGG	0.522000													10	53					0	0	1	0	0
COLEC12	81035	broad.mit.edu	37	18	480750	480750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:480750G>A	ENST00000400256.3	-	2	222	c.15C>T	c.(13-15)ttC>ttT	p.F5F		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	5					carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CCTCCTCTGCGAAGTCGTCTG	0.552000													23	81					0	0	1	0	0
JMJD6	23210	broad.mit.edu	37	17	74720088	74720088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74720088G>A	ENST00000445478.2	-	3	774	c.571C>T	c.(571-573)Ctg>Ttg	p.L191L	JMJD6_ENST00000397625.4_Silent_p.L191L|JMJD6_ENST00000585429.1_Silent_p.L191L	NM_001081461.1	NP_001074930.1	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6	191	JmjC.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			endometrium(2)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|skin(2)	16						CTGGTTCCCAGAGGGTCGATG	0.527000													34	115					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158490620	158490620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:158490620C>T	ENST00000355585.4	+	14	1930	c.1855C>T	c.(1855-1857)Cat>Tat	p.H619Y	SYNJ2_ENST00000367122.2_Missense_Mutation_p.H619Y|SYNJ2_ENST00000367121.3_Missense_Mutation_p.H619Y	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	619							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CTCACGCTCTCATAGATACAT	0.453000													26	27					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663071	22663071	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22663071C>T	ENST00000426066.1	+	0	510					NR_027293.1																						GCCTGATTTTCGGATAGCTGC	0.303000													5	22					0	0	1	0	0
ADAM33	80332	broad.mit.edu	37	20	3655674	3655674	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3655674C>T	ENST00000356518.2	-	4	574	c.333_splice	c.e4+1	p.T111_splice	ADAM33_ENST00000350009.2_Splice_Site_p.T111_splice|ADAM33_ENST00000379861.4_Splice_Site_p.T111_splice	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	111					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						AGCATCTCACCGTGTGGTTGG	0.622000													6	34					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28409123	28409123	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28409123C>T	ENST00000337532.5	-	11	1163	c.887_splice	c.e11+1	p.R296_splice	MPP7_ENST00000445954.2_Splice_Site_p.R171_splice|MPP7_ENST00000540098.1_Splice_Site_p.R296_splice|MPP7_ENST00000375719.3_Splice_Site_p.R296_splice|MPP7_ENST00000375732.1_Splice_Site_p.R296_splice	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	296	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						AGCAGCTCACCTTTCCTGGAA	0.443000													15	65					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14772190	14772190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14772190C>T	ENST00000261170.3	-	24	2966	c.2830G>A	c.(2830-2832)Gga>Aga	p.G944R	RP11-695J4.2_ENST00000542401.1_RNA|RP11-695J4.2_ENST00000545424.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	944	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						ACCGTATCTCCAAATAGACAA	0.478000													27	69					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30365209	30365209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:30365209G>A	ENST00000389194.2	-	1	61	c.56C>T	c.(55-57)tCt>tTt	p.S19F	LTN1_ENST00000361371.4_5'UTR|LTN1_ENST00000389195.2_Missense_Mutation_p.S19F			O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	0							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						GGCGGCGGAAGAGGACACCCT	0.632000													6	9					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3757657	3757657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:3757657C>T	ENST00000252322.1	-	11	1637	c.1169G>A	c.(1168-1170)gGg>gAg	p.G390E	EFCAB4B_ENST00000444507.1_Intron|EFCAB4B_ENST00000440314.2_Intron	NM_032680.3	NP_116069.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	390					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TCCTTCCGACCCCAGGCTTCT	0.592000													16	47					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284411	52284411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52284411C>T	ENST00000301190.6	+	5	908	c.681C>T	c.(679-681)gcC>gcT	p.A227A	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Silent_p.A102A|ANKRD33_ENST00000538991.1_Silent_p.A33A	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	102										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GCAAGACGGCCCTGGAATGGG	0.622000													8	27					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134158754	134158754	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:134158754G>A	ENST00000389887.5	+	7	3195	c.699G>A	c.(697-699)aaG>aaA	p.K233K	GLB1L3_ENST00000431683.2_Silent_p.K233K			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	233					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CATTCAATAAGGATAAAACAT	0.498000													3	24					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170805230	170805230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170805230G>A	ENST00000436636.2	-	24	3131	c.2787C>T	c.(2785-2787)ctC>ctT	p.L929L	TNIK_ENST00000470834.1_Silent_p.L892L|TNIK_ENST00000369326.5_Silent_p.L907L|TNIK_ENST00000475336.1_Silent_p.L837L|TNIK_ENST00000538048.1_Silent_p.L881L|TNIK_ENST00000357327.5_Silent_p.L900L|TNIK_ENST00000488470.1_Silent_p.L874L|TNIK_ENST00000284483.8_Silent_p.L921L|TNIK_ENST00000460047.1_Silent_p.L866L|TNIK_ENST00000341852.6_Silent_p.L845L	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	929	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CCAGGTCAGGGAGGTTGATGT	0.592000													26	83					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54185403	54185403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54185403G>A	ENST00000259782.4	+	2	478	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	TINAG_ENST00000370864.3_Missense_Mutation_p.E110K|TINAG_ENST00000370869.3_Missense_Mutation_p.E124K|TINAG_ENST00000486436.1_3'UTR	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	128					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TCAACATTATGAAGAGGGATC	0.303000													31	109					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15677785	15677785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15677785C>T	ENST00000281171.4	+	11	2259	c.1929C>T	c.(1927-1929)ttC>ttT	p.F643F	PTPRO_ENST00000348962.2_Silent_p.F643F	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	643	Fibronectin type-III 7.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TGGAATATTTCAACAGTCTGT	0.408000													27	68					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8665652	8665652	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:8665652G>A	ENST00000378641.3	+	10	1411	c.936G>A	c.(934-936)ctG>ctA	p.L312L	PLCB1_ENST00000338037.6_Silent_p.L312L|PLCB1_ENST00000378637.2_Silent_p.L312L	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	312					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CTGAGAAACTGGATTTGAATG	0.413000													72	153					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733833	50733833	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50733833A>T	ENST00000300589.2	+	2	613	c.508A>T	c.(508-510)Atc>Ttc	p.I170F	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	170	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				ATGTGATGAAATCAGGTTGCC	0.552000													8	45					0	0	1	0	0
GRWD1	83743	broad.mit.edu	37	19	48953984	48953984	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48953984C>T	ENST00000253237.5	+	5	977	c.744C>T	c.(742-744)ggC>ggT	p.G248G		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	248						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		CGGACGGCGGCTCCTGGCACG	0.637000													12	25					0	0	1	0	0
GNAZ	2781	broad.mit.edu	37	22	23438219	23438219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23438219C>T	ENST00000248996.4	+	2	1003	c.337C>T	c.(337-339)Ccc>Tcc	p.P113S	RTDR1_ENST00000216036.4_Intron	NM_002073.2	NP_002064.1	P19086	GNAZ_HUMAN	guanine nucleotide binding protein (G protein), alpha z polypeptide	113						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(5)|urinary_tract(1)	19	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		GCTGACGGGCCCCGCTGAGAG	0.692000													38	122					0	0	1	0	0
WISP1	8840	broad.mit.edu	37	8	134232995	134232995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134232995G>A	ENST00000250160.6	+	3	627	c.521G>A	c.(520-522)aGc>aAc	p.S174N	WISP1_ENST00000220856.6_Intron|WISP1_ENST00000377863.2_Intron|WISP1_ENST00000519433.1_Intron|WISP1_ENST00000517423.1_Intron	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	174	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CGGCGCGTGAGCATACCTGGC	0.677000													17	52					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78440509	78440509	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78440509G>A	ENST00000278550.7	-	22	3780	c.3318C>T	c.(3316-3318)ttC>ttT	p.F1106F		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GGGCTGCAGCGAACCACTTCC	0.557000													6	9					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255485	15255485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15255485G>A	ENST00000378116.4	-	8	2108	c.2102C>T	c.(2101-2103)cCg>cTg	p.P701L		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	701						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GTGCGGAAGCGGCTTCCCACC	0.577000													31	84					0	0	1	0	0
AVIL	10677	broad.mit.edu	37	12	58197165	58197165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58197165C>T	ENST00000537081.1	-	15	1805	c.1806G>A	c.(1804-1806)caG>caA	p.Q602Q	AVIL_ENST00000550083.1_5'UTR|TSFM_ENST00000548851.1_Intron|AVIL_ENST00000257861.3_Silent_p.Q609Q			O75366	AVIL_HUMAN	advillin	609	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CTAGGATTTCCTGCTGAAGTC	0.438000											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	66	125					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53201524	53201524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53201524C>T	ENST00000551956.1	-	7	1742	c.1250G>A	c.(1249-1251)cGa>cAa	p.R417Q	KRT4_ENST00000458244.2_Missense_Mutation_p.R397Q|KRT4_ENST00000293774.4_Missense_Mutation_p.R491Q			B4DRS2	B4DRS2_HUMAN	keratin 4	417						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						ACGCAGCATTCGTGCCAGCTC	0.597000													62	87					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131487353	131487353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:131487353G>A	ENST00000376682.4	+	1	310	c.55G>A	c.(55-57)Gat>Aat	p.D19N	GPR133_ENST00000535015.1_Intron|GPR133_ENST00000261654.5_Intron			Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	0					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ACCTGGGGGCGATCAGCCCCT	0.642000													6	19					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4231306	4231306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4231306C>T	ENST00000221847.5	+	2	239	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	62	Fibronectin type-III 1.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGTGTCCTTCATTGCCACGT	0.652000													12	20					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135447811	135447811	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135447811G>A	ENST00000343036.2	+	7	925	c.877G>A	c.(877-879)Gat>Aat	p.D293N	C9orf171_ENST00000393216.2_Missense_Mutation_p.D257N	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	293										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						CACGGAGGCCGATCGCCAGAG	0.622000													34	57					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087792	47087792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:47087792G>A	ENST00000374312.1	+	3	1428	c.1009G>A	c.(1009-1011)Gtg>Atg	p.V337M	NPY4R_ENST00000395716.1_Missense_Mutation_p.V337M	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		CAAGGCCCTGGTGCTGACTTG	0.562000													18	120					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196723513	196723513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196723513C>T	ENST00000312428.6	-	43	7852	c.7752G>A	c.(7750-7752)atG>atA	p.M2584I		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2584	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATCTCTTTTTCATTTTCATTA	0.368000													38	118					0	0	1	0	0
DDB2	1643	broad.mit.edu	37	11	47256474	47256474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47256474C>T	ENST00000256996.4	+	6	1064	c.869C>T	c.(868-870)cCt>cTt	p.P290L	DDB2_ENST00000378603.3_Missense_Mutation_p.P226L|DDB2_ENST00000378601.3_Intron|DDB2_ENST00000378600.3_Intron	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	290					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						CACAGGCATCCTGTCAACGCA	0.562000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				16	17					0	0	1	0	0
QSOX1	5768	broad.mit.edu	37	1	180166062	180166062	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:180166062C>A	ENST00000367602.3	+	12	2208	c.2134C>A	c.(2134-2136)Ctc>Atc	p.L712I	QSOX1_ENST00000367600.5_Intron			O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1	712					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						GGACATCAGCCTCTGTGTGGG	0.647000													22	42					1.64293e-13	1.65114e-13	1	1	0
CEP128	145508	broad.mit.edu	37	14	81251861	81251861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81251861G>A	ENST00000555265.1	-	15	1964	c.1589C>T	c.(1588-1590)aCc>aTc	p.T530I	CEP128_ENST00000281129.3_Missense_Mutation_p.T530I			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	530						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						ATACAGCTGGGTTTTCAATTC	0.368000													5	15					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55421032	55421032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55421032C>T	ENST00000242994.3	+	2	1187	c.809C>T	c.(808-810)tCt>tTt	p.S270F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	270					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						CAAGATGGGTCTCCTGACCTA	0.522000													50	172					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71532512	71532512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71532512C>T	ENST00000265382.3	+	9	1125	c.820C>T	c.(820-822)Cat>Tat	p.H274Y	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.H274Y	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	274	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		GTTGGGAATTCATTTCCTGGA	0.473000													99	295					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57598915	57598915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57598915C>T	ENST00000243077.3	+	73	11684	c.11218C>T	c.(11218-11220)Cac>Tac	p.H3740Y		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3740	LDL-receptor class A 31.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCACACCACCCACTGCAAAGA	0.612000													23	66					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37602897	37602897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37602897G>A	ENST00000328544.3	-	2	1479	c.946C>T	c.(946-948)Ctc>Ttc	p.L316F	SSTR3_ENST00000402501.1_Missense_Mutation_p.L316F	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	316					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						CGGTAGGAGAGGAAGCCATAA	0.657000													29	75					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106918708	106918708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106918708G>A	ENST00000369701.3	+	11	1915	c.1688G>A	c.(1687-1689)aGa>aAa	p.R563K		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	563						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCCTCAGGAAGAATCTCTAGC	0.418000													36	65					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233297093	233297093	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233297093C>T	ENST00000258229.8	-	18	3524	c.3290G>A	c.(3289-3291)tGg>tAg	p.W1097*	PCNXL2_ENST00000488780.2_Nonsense_Mutation_p.W230*	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1097						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GATGAGATCCCATTTTAAGAC	0.473000													5	23					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8518118	8518118	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8518118G>A	ENST00000381196.4	-	18	1816	c.1273C>T	c.(1273-1275)Cag>Tag	p.Q425*	PTPRD_ENST00000397611.3_Nonsense_Mutation_p.Q422*|PTPRD_ENST00000397617.3_Nonsense_Mutation_p.Q415*|PTPRD_ENST00000540109.1_Nonsense_Mutation_p.Q425*|PTPRD_ENST00000360074.4_Nonsense_Mutation_p.Q412*|PTPRD_ENST00000537002.1_Nonsense_Mutation_p.Q422*|PTPRD_ENST00000358503.5_Nonsense_Mutation_p.Q412*|PTPRD_ENST00000486161.1_Nonsense_Mutation_p.Q425*|PTPRD_ENST00000356435.5_Nonsense_Mutation_p.Q425*|PTPRD_ENST00000355233.5_Nonsense_Mutation_p.Q425*|PTPRD_ENST00000397606.3_Nonsense_Mutation_p.Q415*	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	425	Fibronectin type-III 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATTCGTGCCTGGACATCCCTC	0.502000										TSP Lung(15;0.13)			55	93					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155508777	155508777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155508777C>T	ENST00000302053.3	-	4	475	c.397G>A	c.(397-399)Gat>Aat	p.D133N	FGA_ENST00000403106.3_Missense_Mutation_p.D133N	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	133					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CTTCTCAGATCCTCTGACACT	0.393000													30	87					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348709	140348709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348709C>T	ENST00000289269.5	+	1	2890	c.2358C>T	c.(2356-2358)tcC>tcT	p.S786S	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		786					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAATGGCTCCCTCACCAAGA	0.512000													20	54					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145109544	145109544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145109544G>A	ENST00000426825.1	-	19	2687	c.2606C>T	c.(2605-2607)cCc>cTc	p.P869L	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	869							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GGTGGAGTGGGGGGGCATGGA	0.642000													6	38					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11052823	11052823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11052823G>A	ENST00000295082.1	+	1	761	c.271G>A	c.(271-273)Gag>Aag	p.E91K		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	91						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GTGTGTCATCGAGGTGTACTA	0.562000													19	40					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122774533	122774533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122774533G>A	ENST00000194130.2	-	8	902	c.863C>T	c.(862-864)tCc>tTc	p.S288F	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	288						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	AGCTGGGAAGGAAAACGTAAA	0.433000													21	58					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45295117	45295117	+	Missense_Mutation	SNP	G	G	A	rs56126236		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:45295117G>A	ENST00000447098.2	-	9	1183	c.1172C>T	c.(1171-1173)tCt>tTt	p.S391F	PTCH2_ENST00000372192.3_Missense_Mutation_p.S391F	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	391					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					ACTGACTTCAGAGAACGCATG	0.622000									Basal Cell Nevus syndrome				36	100					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108006601	108006601	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108006601G>A	ENST00000280758.5	+	6	2382	c.1854G>A	c.(1852-1854)gcG>gcA	p.A618A	BTBD11_ENST00000420571.2_Silent_p.A618A|RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000490090.2_Silent_p.A618A|BTBD11_ENST00000357167.4_Silent_p.A155A	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	618						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GGGACGAGGCGATGGTTCAGA	0.602000													7	22					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47406492	47406492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47406492C>T	ENST00000361866.3	+	4	595	c.481C>T	c.(481-483)Ccc>Tcc	p.P161S		NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	161	N-terminal globular domain.|VWFA 1.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CGACGGGCACCCCCTGGAGGG	0.617000													3	6					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65264471	65264471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65264471C>T	ENST00000389722.3	-	9	1211	c.1158G>A	c.(1156-1158)ggG>ggA	p.G386G	SPTB_ENST00000556626.1_Silent_p.G386G|SPTB_ENST00000542895.1_Silent_p.G386G|SPTB_ENST00000389721.5_Silent_p.G386G|SPTB_ENST00000389720.3_Silent_p.G386G	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	386					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		ACACTAGTTTCCCATCGTGGG	0.443000													38	147					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66873806	66873806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66873806C>T	ENST00000269080.2	-	31	4070	c.3933G>A	c.(3931-3933)ggG>ggA	p.G1311G	ABCA8_ENST00000586539.1_Silent_p.G1351G|ABCA8_ENST00000430352.2_Silent_p.G1351G	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1311	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					CTCCACCGCTCCCTTTCAGTA	0.557000													31	90					0	0	1	0	0
CCDC172	374355	broad.mit.edu	37	10	118084563	118084563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118084563G>A	ENST00000333254.3	+	2	291	c.40G>A	c.(40-42)Gag>Aag	p.E14K	CCDC172_ENST00000497093.1_3'UTR	NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		CATCTTCACCGAGCATCAGGC	0.522000													21	70					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588020	247588020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247588020G>A	ENST00000366497.2	+	4	2055	c.1275G>A	c.(1273-1275)caG>caA	p.Q425Q	NLRP3_ENST00000391828.3_Silent_p.Q425Q|NLRP3_ENST00000336119.3_Silent_p.Q425Q|NLRP3_ENST00000391827.2_Silent_p.Q425Q|NLRP3_ENST00000348069.2_Silent_p.Q425Q|NLRP3_ENST00000366496.2_Silent_p.Q425Q|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	425	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGAAACAGCAGATGGAGAGTG	0.587000													24	59					0	0	1	0	0
ASB14	142686	broad.mit.edu	37	3	57312513	57312513	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:57312513C>T	ENST00000487349.1	-	8	1443	c.1323G>A	c.(1321-1323)ctG>ctA	p.L441L	ASB14_ENST00000389601.3_Silent_p.L441L	NM_001142733.2|NM_130387.5	NP_001136205.2|NP_569058.1	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box containing 14	441					intracellular signal transduction					central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		ACCCATAGTTCAGCAGCATCC	0.438000													38	118					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113520119	113520119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113520119G>A	ENST00000284601.3	-	4	1096	c.1028C>T	c.(1027-1029)tCa>tTa	p.S343L		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	343					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TGGATCTGTTGAAAATGTATT	0.353000													50	142					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86905850	86905850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86905850G>A	ENST00000370565.4	+	8	1385	c.1223G>A	c.(1222-1224)gGa>gAa	p.G408E		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	408	VWFA.				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AAACTGAATGGAAAAGCTTAT	0.393000													51	139					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196053	207196053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207196053C>T	ENST00000359470.5	-	4	1305	c.1056G>A	c.(1054-1056)gaG>gaA	p.E352E	C1orf116_ENST00000461135.2_Silent_p.E106E	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	352						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					GCCCCAGCTTCTCTAGAGCTT	0.572000													13	89					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111096	55111096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55111096C>T	ENST00000314721.2	+	1	470	c.420C>T	c.(418-420)atC>atT	p.I140I		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						TGGTTTGCATCCTTCTGTTGG	0.468000													59	122					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177250629	177250629	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177250629C>T	ENST00000361539.4	+	8	2629	c.2317C>T	c.(2317-2319)Cct>Tct	p.P773S	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		773						extracellular region		p.P773A(1)		breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						GCTGCCAAACCCTGTGGAATA	0.532000													26	87					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29142318	29142318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29142318G>A	ENST00000377167.2	+	1	1008	c.906G>A	c.(904-906)gcG>gcA	p.A302A		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						AAGGGGCAGCGAAGAGACTAT	0.453000													18	71					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106526580	106526580	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:106526580G>A	ENST00000359195.3	+	10	3183	c.2872_splice	c.e10-1	p.G958_splice	PIK3CG_ENST00000440650.2_Splice_Site_p.G958_splice|PIK3CG_ENST00000496166.1_Splice_Site_p.G958_splice	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	958	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						TTCTCTTAAGGAAACCTATTT	0.373000													13	45					0	0	1	0	0
IGHV2-5	28457	broad.mit.edu	37	14	106494237	106494237	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106494237C>T	ENST00000390597.2	-	0	274																											TGAGCCTGCTCTTCAGAGATG	0.532000													15	96					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183096487	183096487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183096487C>T	ENST00000258341.4	+	17	3328	c.3071C>T	c.(3070-3072)tCt>tTt	p.S1024F	LAMC1_ENST00000466964.1_3'UTR	NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	1024	Laminin EGF-like 11.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACAATCGGTCTTGGCCTGGC	0.463000													29	70					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98744738	98744738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98744738C>T	ENST00000477737.1	+	6	943	c.739C>T	c.(739-741)Cct>Tct	p.P247S	VWA3B_ENST00000451075.2_Missense_Mutation_p.P97S|VWA3B_ENST00000435344.1_Missense_Mutation_p.P247S	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	247										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGGGGATGTTCCTGAAGAATC	0.498000													47	108					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417464	150417464	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150417464C>T	ENST00000307194.5	+	3	512	c.372C>T	c.(370-372)ttC>ttT	p.F124F		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGTCGGTTCACCGCCCAGG	0.627000													16	39					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3656589	3656589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3656589C>T	ENST00000263087.4	-	14	1761	c.1663G>A	c.(1663-1665)Gag>Aag	p.E555K		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	555					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CCCACCTGCTCGCTGAGACGG	0.572000													6	12					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433410	140433410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140433410G>A	ENST00000306549.3	+	1	2432	c.2355G>A	c.(2353-2355)ggG>ggA	p.G785G		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		785					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGCCACTGGGGAGATAAAAA	0.453000													40	106					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101592853	101592853	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101592853C>T	ENST00000310954.6	-	8	1721	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	479					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GCAAATGGCTCATTTTCACAT	0.328000													23	56					0	0	1	0	0
POMGNT1	55624	broad.mit.edu	37	1	46659974	46659974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46659974G>A	ENST00000371992.1	-	9	1501	c.851C>T	c.(850-852)cCc>cTc	p.P284L	POMGNT1_ENST00000371984.3_Missense_Mutation_p.P284L|POMGNT1_ENST00000396420.3_3'UTR|POMGNT1_ENST00000371986.3_Missense_Mutation_p.P284L|POMGNT1_ENST00000535522.1_Missense_Mutation_p.P262L	NM_001243766.1	NP_001230695.1	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	284					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					GATGGGTGTGGGGTCCTTGCA	0.602000													21	60					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045554	53045554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53045554C>T	ENST00000309680.3	-	1	394	c.373G>A	c.(373-375)Ggt>Agt	p.G125S		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	125	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		cccccaaaacctccaaagcgg	0.617000													9	29					0	0	1	0	0
UCHL1	7345	broad.mit.edu	37	4	41263915	41263915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41263915C>T	ENST00000284440.4	+	6	578	c.434C>T	c.(433-435)gCc>gTc	p.A145V	UCHL1_ENST00000503431.1_Missense_Mutation_p.A145V|UCHL1_ENST00000512788.1_Missense_Mutation_p.A145V|UCHL1_ENST00000508768.1_Intron|UCHL1_ENST00000504818.1_3'UTR	NM_004181.4	NP_004172.2	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	145					cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|skin(2)	8						GCCCATGATGCCGTGGCACAG	0.458000													6	42					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35778739	35778739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:35778739G>A	ENST00000187397.4	+	16	1985	c.1529G>A	c.(1528-1530)cGa>cAa	p.R510Q	ARPP21_ENST00000458225.1_Missense_Mutation_p.R476Q|ARPP21_ENST00000417925.1_Missense_Mutation_p.R476Q|ARPP21_ENST00000444190.1_Missense_Mutation_p.R456Q|ARPP21_ENST00000337271.5_Missense_Mutation_p.R456Q	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	510	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CAGCCCCTGCGAAGCGCCATG	0.612000													68	70					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40123361	40123361	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40123361T>A	ENST00000261435.6	+	9	4046	c.3630T>A	c.(3628-3630)acT>acA	p.T1210T		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1210						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						GAGCTGTCACTCCTGAAAACC	0.423000													40	73					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183711395	183711395	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183711395C>T	ENST00000304685.3	+	2	564	c.103C>T	c.(103-105)Cga>Tga	p.R35*	RGL1_ENST00000536277.1_Nonsense_Mutation_p.R35*|RGL1_ENST00000367531.1_Nonsense_Mutation_p.R35*	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	0					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						AGATCATGTTCGAATATGGGA	0.423000													32	132					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64216856	64216856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64216856G>A	ENST00000205948.6	-	5	457	c.420C>T	c.(418-420)atC>atT	p.I140I		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	140	Sushi 3.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			GAGGGCAGATGATGGCTGGGA	0.368000													30	72					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39159080	39159080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39159080C>T	ENST00000359534.3	-	5	1424	c.1086G>A	c.(1084-1086)ctG>ctA	p.L362L		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	362					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						CTTTGCTCCTCAGTGTCTGTG	0.632000													13	38					0	0	1	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89416832	89416832	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89416832G>A	ENST00000490686.1	-	0	378																											AACACTGTGGGAGGGTAACTA	0.522000													31	110					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74153399	74153399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74153399G>A	ENST00000443185.2	-	3	1929	c.1612C>T	c.(1612-1614)Cgc>Tgc	p.R538C	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	538					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CGCGCGCGGCGATGCACGCGT	0.701000													14	19					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24835206	24835206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24835206G>A	ENST00000376454.3	+	21	5815	c.5785G>A	c.(5785-5787)Gga>Aga	p.G1929R	KIAA1217_ENST00000376452.3_Missense_Mutation_p.G1360R|KIAA1217_ENST00000458595.1_Missense_Mutation_p.G1335R|KIAA1217_ENST00000376462.1_Missense_Mutation_p.G1250R|KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000396445.1_3'UTR	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1929					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGCACAGAATGGAAGTTCAAG	0.483000													26	61					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124355019	124355019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124355019C>T	ENST00000409039.3	+	43	7297	c.7272C>T	c.(7270-7272)ttC>ttT	p.F2424F		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2424	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGAGGAAATTCATCAACATCC	0.438000													9	29					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6262879	6262879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6262879G>A	ENST00000379936.2	+	5	1251	c.1136G>A	c.(1135-1137)gGa>gAa	p.G379E	CNGA4_ENST00000533426.1_Missense_Mutation_p.G148E	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	379					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCGCAAAGGAGACATTGGC	0.552000													54	205					0	0	1	0	0
KBTBD13	390594	broad.mit.edu	37	15	65370431	65370431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65370431G>A	ENST00000432196.2	+	1	1278	c.1278G>A	c.(1276-1278)gaG>gaA	p.E426E		NM_001101362.2	NP_001094832.1	C9JR72	KBTBD_HUMAN	kelch repeat and BTB (POZ) domain containing 13	426						cytoplasm				lung(1)|prostate(1)|skin(1)	3						TGCTCAGGGAGAAAGCCGGCT	0.647000													5	16					0	0	1	0	0
PDCD10	11235	broad.mit.edu	37	3	167437899	167437899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167437899G>A	ENST00000392750.2	-	3	464	c.47C>T	c.(46-48)tCc>tTc	p.S16F	PDCD10_ENST00000470131.1_Missense_Mutation_p.S16F|PDCD10_ENST00000492396.1_Intron|PDCD10_ENST00000471885.1_Missense_Mutation_p.S16F|PDCD10_ENST00000461494.1_Missense_Mutation_p.S16F|PDCD10_ENST00000473645.2_Missense_Mutation_p.S16F|PDCD10_ENST00000497056.2_Missense_Mutation_p.S16F|PDCD10_ENST00000487947.2_Missense_Mutation_p.S16F	NM_007217.3	NP_009148.2	Q9BUL8	PDC10_HUMAN	programmed cell death 10	16					angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			central_nervous_system(1)|kidney(1)|lung(8)|urinary_tract(2)	12						AGAAACCATGGATGTGGTCTC	0.398000													30	76					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71144021	71144021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71144021G>A	ENST00000344870.4	-	2	271	c.239C>T	c.(238-240)tCg>tTg	p.S80L	LARP6_ENST00000299213.8_Intron|LARP6_ENST00000560052.1_5'UTR	NM_197958.1	NP_932062.1	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	0					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						tacaatgaacgaagcaagcat	0.443000													33	57					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62265794	62265794	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62265794G>A	ENST00000258991.3	-	5	2263	c.2179C>T	c.(2179-2181)Ccc>Tcc	p.P727S	TEX2_ENST00000584379.1_Intron|TEX2_ENST00000583097.1_Intron			Q8IWB9	TEX2_HUMAN	testis expressed 2	724				PGLLP -> LRAFA (in Ref. 2; CAH10519).	signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AAGAAGACGGGGGCTATTCAC	0.493000													14	54					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19460865	19460865	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19460865G>A	ENST00000396229.2	+	5	1709	c.958_splice	c.e5-1	p.V320_splice	TMC5_ENST00000542583.2_Splice_Site_p.V320_splice|TMC5_ENST00000541464.1_Splice_Site_p.V320_splice|TMC5_ENST00000381414.4_Splice_Site_p.V320_splice	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	320						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TCCCTCCAGTGAACCCTGCTT	0.463000													31	122					0	0	1	0	0
GMPR2	51292	broad.mit.edu	37	14	24702446	24702446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24702446C>T	ENST00000557854.1	+	1	318	c.41C>T	c.(40-42)cCg>cTg	p.P14L	GMPR2_ENST00000559104.1_Missense_Mutation_p.P14L|GMPR2_ENST00000355299.4_5'UTR|GMPR2_ENST00000399440.2_5'UTR|GMPR2_ENST00000348719.7_5'UTR|GMPR2_ENST00000420554.2_Missense_Mutation_p.P14L|GMPR2_ENST00000456667.3_5'UTR|GMPR2_ENST00000559836.1_5'UTR|GMPR2_ENST00000559910.1_5'UTR			Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2	0					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			large_intestine(4)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(265;0.0181)		ATCGCTACCCCGAGGCTAAGC	0.527000													95	231					0	0	1	0	0
DDX42	11325	broad.mit.edu	37	17	61886222	61886222	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61886222C>T	ENST00000578681.1	+	11	1667	c.1066C>T	c.(1066-1068)Cga>Tga	p.R356*	DDX42_ENST00000583590.1_Nonsense_Mutation_p.R356*|DDX42_ENST00000359353.5_Nonsense_Mutation_p.R237*|DDX42_ENST00000457800.2_Nonsense_Mutation_p.R356*|DDX42_ENST00000389924.2_Nonsense_Mutation_p.R356*	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	356	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						ATATAATCTTCGATCAGTGGC	0.443000													29	119					0	0	1	0	0
BLVRB	645	broad.mit.edu	37	19	40953902	40953902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40953902G>A	ENST00000263368.4	-	5	666	c.515C>T	c.(514-516)cCc>cTc	p.P172L	BLVRB_ENST00000595483.1_Missense_Mutation_p.P129L	NM_000713.2	NP_000704.1	P30043	BLVRB_HUMAN	biliverdin reductase B (flavin reductase (NADPH))	172					heme catabolic process	cytosol	biliverdin reductase activity|binding|flavin reductase activity			large_intestine(3)|lung(3)	6			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)		NADH(DB00157)|Riboflavin(DB00140)	GACCCTTGAGGGCCCTCGTCC	0.562000													15	50					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124401103	124401103	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124401103C>T	ENST00000409039.3	+	62	10493	c.10468C>T	c.(10468-10470)Cct>Tct	p.P3490S		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3490	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATACATCGATCCTGTGATTGA	0.433000													14	73					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241172	126241172	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126241172T>G	ENST00000394329.3	+	1	3619	c.3606T>G	c.(3604-3606)gaT>gaG	p.D1202E		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1202	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ACATGAAGGATATAAATGATA	0.418000													22	64					0	0	1	0	0
ZNF696	79943	broad.mit.edu	37	8	144378535	144378535	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144378535C>T	ENST00000330143.3	+	3	1099	c.690C>T	c.(688-690)acC>acT	p.T230T		NM_030895.2	NP_112157.2	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			ACCGCCGCACCCACACCGGGG	0.726000													3	17					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46375487	46375487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46375487G>A	ENST00000302177.2	+	2	421	c.224G>A	c.(223-225)gGg>gAg	p.G75E		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	75					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		GCCCCCCTGGGGCCCACTTTC	0.711000													11	42					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33941323	33941323	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33941323C>T	ENST00000389232.4	+	31	4099	c.4029C>T	c.(4027-4029)gtC>gtT	p.V1343V	RYR3_ENST00000415757.3_Silent_p.V1343V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1343	4 X approximate repeats.|B30.2/SPRY 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CATCCTGTGTCTGGGTCGGAT	0.542000													47	121					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3614674	3614674	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3614674G>A	ENST00000301749.7	-	0	669				NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000359128.5_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GCAGGAGGGAGGCCAGCCTGT	0.706000													4	16					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7340402	7340402	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:7340402C>T	ENST00000486284.1	+	3	1042	c.768C>T	c.(766-768)atC>atT	p.I256I	GRM7_ENST00000403881.1_Silent_p.I256I|GRM7_ENST00000389336.4_Silent_p.I256I|GRM7_ENST00000402647.2_Silent_p.I256I|GRM7_ENST00000357716.4_Silent_p.I256I	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	256					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CCGTGAGAATCCCCCAGGAAC	0.473000													33	63					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135485428	135485428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135485428C>T	ENST00000394143.1	+	22	8892	c.8601C>T	c.(8599-8601)atC>atT	p.I2867I	GPR112_ENST00000370652.1_Silent_p.I2867I|GPR112_ENST00000394141.1_Silent_p.I2662I|GPR112_ENST00000412101.1_Silent_p.I2662I|GPR112_ENST00000287534.4_Silent_p.I2620I	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2867					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGGTGGCAATCACAGTCAGTG	0.502000													12	39					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20825709	20825709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20825709G>A	ENST00000328879.4	-	3	477	c.321C>T	c.(319-321)ttC>ttT	p.F107F	KLHL22_ENST00000440659.2_Intron	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	107	BTB.				cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AGGTGTATATGAAATGTAGGA	0.512000													45	84					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4929324	4929324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4929324C>T	ENST00000359350.4	+	1	725	c.725C>T	c.(724-726)tCc>tTc	p.S242F	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACCTGTGTCTCCCACATCTGT	0.468000													71	166					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537225	5537225	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5537225G>A	ENST00000380184.1	-	1	710	c.447C>T	c.(445-447)gcC>gcT	p.A149A	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	149										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CCACAAAGTGGGCCAGTTCCA	0.527000													9	95					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030033	95030033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95030033G>A	ENST00000557004.1	+	2	635	c.214G>A	c.(214-216)Ggg>Agg	p.G72R	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Missense_Mutation_p.G72R|SERPINA4_ENST00000298841.5_Missense_Mutation_p.G72R			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	72					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		GGAGACCCCGGGGAAGAACAT	0.607000													32	74					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121942288	121942288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121942288C>T	ENST00000442488.2	-	4	1258	c.1191G>A	c.(1189-1191)aaG>aaA	p.K397K	FEZF1_ENST00000331178.4_Silent_p.K393K|FEZF1_ENST00000427185.2_Silent_p.K347K	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	397					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						TGAAAGGCTTCTTGTCGTTGT	0.562000													50	135					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108013935	108013935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108013935G>A	ENST00000280758.5	+	11	3153	c.2625G>A	c.(2623-2625)gcG>gcA	p.A875A	BTBD11_ENST00000420571.2_Silent_p.A756A|BTBD11_ENST00000490090.2_Silent_p.A875A|BTBD11_ENST00000357167.4_Silent_p.A412A	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	875						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TCCTGAAAGCGAGCAAGGTAT	0.507000													9	77					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56343630	56343630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56343630C>T	ENST00000262290.4	+	11	1952	c.1636C>T	c.(1636-1638)Cat>Tat	p.H546Y	LPO_ENST00000421678.2_Missense_Mutation_p.H463Y|LPO_ENST00000543544.1_Missense_Mutation_p.H487Y|LPO_ENST00000582328.1_Missense_Mutation_p.H463Y	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	546					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						TCACAGGATCCATGGCTTTGA	0.532000													4	44					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86468644	86468644	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86468644C>T	ENST00000361669.2	+	4	2913	c.1814C>T	c.(1813-1815)cCc>cTc	p.P605L	GRM3_ENST00000394720.2_Intron|GRM3_ENST00000546348.1_Missense_Mutation_p.P197L|GRM3_ENST00000439827.1_Intron|GRM3_ENST00000536043.1_Missense_Mutation_p.P477L	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	605					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AACAACACACCCTTGGTCAAA	0.483000													23	85					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101593663	101593663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101593663G>A	ENST00000310954.6	-	7	1543	c.1257C>T	c.(1255-1257)ttC>ttT	p.F419F		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	419					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GAGTAGCTGCGAAGCTGGATG	0.294000													9	80					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495309	71495309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71495309G>A	ENST00000296755.7	+	5	6425	c.6127G>A	c.(6127-6129)Gag>Aag	p.E2043K		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2043						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ATACTGTTACGAGACTGCAGA	0.448000													37	131					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20974808	20974808	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20974808G>A	ENST00000261383.3	-	53	10397	c.10398C>T	c.(10396-10398)ttC>ttT	p.F3466F	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3466					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATCCTTGAGAGAACTTCCAAG	0.522000													5	55					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181764142	181764142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181764142C>T	ENST00000526775.1	+	44	6149	c.5984C>T	c.(5983-5985)tCc>tTc	p.S1995F	CACNA1E_ENST00000367570.1_Missense_Mutation_p.S2014F|CACNA1E_ENST00000367567.4_Missense_Mutation_p.S1621F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.S2038F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.S2008F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.S1946F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.S2057F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2057					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TACCACTCCTCCTTGCGGCTG	0.542000													10	41					0	0	1	0	0
DUSP26	78986	broad.mit.edu	37	8	33449694	33449694	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:33449694C>T	ENST00000256261.4	-	4	990	c.473G>A	c.(472-474)cGa>cAa	p.R158Q	DUSP26_ENST00000523956.1_Missense_Mutation_p.R158Q	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	158	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		GGTGGCGGATCGGCTCACGCC	0.577000													9	18					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40061891	40061891	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40061891C>T	ENST00000336649.4	+	26	4002	c.4002C>T	c.(4000-4002)ttC>ttT	p.F1334F	CACNA1I_ENST00000407673.1_Silent_p.F1293F|CACNA1I_ENST00000404898.1_Silent_p.F1293F|CACNA1I_ENST00000402142.3_Silent_p.F1328F|CACNA1I_ENST00000401624.1_Silent_p.F1328F|CACNA1I_ENST00000400164.3_Silent_p.F1293F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1328					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding	p.F1328L(1)|p.F1293L(1)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCCAGCTCTTCAAGGGCAAGT	0.567000													43	104					0	0	1	0	0
QRFP	347148	broad.mit.edu	37	9	133768912	133768912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133768912C>T	ENST00000343079.1	-	1	313	c.314G>A	c.(313-315)gGg>gAg	p.G105E		NM_198180.1	NP_937823.1	P83859	OX26_HUMAN	pyroglutamylated RFamide peptide	105					locomotory behavior|neuropeptide signaling pathway|positive regulation of blood pressure|regulation of feeding behavior	extracellular region	neuropeptide hormone activity|orexigenic neuropeptide QRFP receptor binding			cervix(1)|endometrium(3)|lung(1)|skin(2)	7	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.17e-05)|Epithelial(140;0.000267)		GGTCTTCTCCCCCGCAGCAGG	0.647000													36	106					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447684	226447684	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:226447684C>T	ENST00000272907.6	+	4	1964	c.1551C>T	c.(1549-1551)ctC>ctT	p.L517L	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	517																	TGACCAGCCTCTTCTCCTCCG	0.697000													9	19					0	0	1	0	0
BBOX1	8424	broad.mit.edu	37	11	27077035	27077035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:27077035C>T	ENST00000263182.3	+	3	426	c.58C>T	c.(58-60)Ctc>Ttc	p.L20F	BBOX1_ENST00000528583.1_Missense_Mutation_p.L20F|RP11-1L12.3_ENST00000526061.1_RNA|BBOX1_ENST00000527505.1_3'UTR|BBOX1_ENST00000529202.1_Missense_Mutation_p.L20F|BBOX1_ENST00000525090.1_Missense_Mutation_p.L20F	NM_003986.2	NP_003977.1	O75936	BODG_HUMAN	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	20					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	23					Succinic acid(DB00139)|Vitamin C(DB00126)	GATGCAGATCCTCTGGTATGA	0.498000													26	60					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999223	27999223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27999223C>T	ENST00000441525.1	-	1	343	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	77	Glu-rich.									NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						TCGACGTCTTCACTTGAACTT	0.488000													40	39					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141609344	141609344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141609344G>A	ENST00000389484.3	-	28	5559	c.4588C>T	c.(4588-4590)Cct>Tct	p.P1530S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1530					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCTGCACAAGGATTGGGAGCT	0.453000										TSP Lung(27;0.18)			35	100					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539793	94539793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94539793G>A	ENST00000289495.5	+	1	584	c.368G>A	c.(367-369)cGa>cAa	p.R123Q	PPP1R9A_ENST00000424654.1_Missense_Mutation_p.R123Q|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.R123Q|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.R123Q|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.R123Q|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.R123Q	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	123	Actin-binding.					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GTTTCTGAACGAATTAGTAGA	0.403000										HNSCC(28;0.073)			39	109					0	0	1	0	0
LIMD1	8994	broad.mit.edu	37	3	45637408	45637408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45637408C>T	ENST00000273317.4	+	1	1058	c.1037C>T	c.(1036-1038)tCc>tTc	p.S346F	LIMD1_ENST00000465039.1_Intron|LIMD1_ENST00000440097.1_Missense_Mutation_p.S346F	NM_014240.2	NP_055055.1	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	346					cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		TCTTACCTTTCCAGTTCTGCC	0.612000													16	73					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96294492	96294492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96294492C>T	ENST00000277165.6	+	10	1984	c.1790C>T	c.(1789-1791)cCg>cTg	p.P597L	FAM120A_ENST00000333936.5_Missense_Mutation_p.P625L|FAM120A_ENST00000340893.4_Missense_Mutation_p.P597L|FAM120A_ENST00000475933.1_3'UTR	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	597						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GACCTGCCTCCGGCCGCTCTG	0.418000													47	171					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655984	40655984	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:40655984G>A	ENST00000406785.1	-	2	1626	c.1437C>T	c.(1435-1437)atC>atT	p.I479I	SLC8A1_ENST00000542024.1_Silent_p.I479I|SLC8A1_ENST00000542756.1_Silent_p.I479I|SLC8A1_ENST00000332839.4_Silent_p.I479I|SLC8A1_ENST00000405901.3_Silent_p.I479I|SLC8A1_ENST00000403092.1_Silent_p.I479I|SLC8A1_ENST00000405269.1_Silent_p.I479I|SLC8A1_ENST00000402441.1_Silent_p.I479I|SLC8A1_ENST00000408028.2_Silent_p.I479I|SLC8A1_ENST00000406391.2_Silent_p.I479I			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	479	Calx-beta 1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CATCATCTATGATACCCACTC	0.423000													32	59					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181705452	181705452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181705452G>A	ENST00000526775.1	+	21	3412	c.3247G>A	c.(3247-3249)Gca>Aca	p.A1083T	CACNA1E_ENST00000367570.1_Missense_Mutation_p.A1102T|CACNA1E_ENST00000367567.4_Missense_Mutation_p.A709T|CACNA1E_ENST00000360108.3_Missense_Mutation_p.A1083T|CACNA1E_ENST00000357570.5_Missense_Mutation_p.A1053T|CACNA1E_ENST00000358338.5_Missense_Mutation_p.A1034T|CACNA1E_ENST00000367573.2_Missense_Mutation_p.A1102T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1102					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTGAAGGAGGCAGAGATCAG	0.498000													9	13					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45706614	45706614	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45706614G>A	ENST00000291582.5	+	2	434	c.307_splice	c.e2+1	p.D103_splice		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	103	HSR.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		CTTCCCCAAAGGTGGGTCCTG	0.637000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				23	68					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628755	3628755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3628755C>T	ENST00000325418.4	+	1	1545	c.1526C>T	c.(1525-1527)gCc>gTc	p.A509V	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	509	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										ACACCCGTAGCCATAAAAATC	0.443000													32	33					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003810	57003810	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57003810G>A	ENST00000606794.1	-	1	865	c.669C>T	c.(667-669)ttC>ttT	p.F223F		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	223						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TTTGGGCGATGAAGAAGTAAC	0.627000													20	66					0	0	1	0	0
GAA	2548	broad.mit.edu	37	17	78084546	78084546	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78084546C>T	ENST00000302262.3	+	10	1677	c.1458C>T	c.(1456-1458)gcC>gcT	p.A486A	GAA_ENST00000390015.3_Silent_p.A486A	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	486					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGTCCACTGCCTTCCCCGACT	0.647000													6	78					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97081904	97081904	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:97081904G>A	ENST00000335456.7	-	7	1451	c.1431C>T	c.(1429-1431)acC>acT	p.T477T	NUTM2F_ENST00000253262.4_Silent_p.T492T|NUTM2F_ENST00000341207.4_Silent_p.T477T					NUT family member 2F																		CCTGGGCAAGGGTGAGTCCTT	0.612000													66	111					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57938654	57938654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57938654G>A	ENST00000564448.1	-	26	2660	c.2600C>T	c.(2599-2601)tCt>tTt	p.S867F	CNGB1_ENST00000251102.8_Missense_Mutation_p.S873F			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	873					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GATCATCACAGAGAAAGCAAA	0.572000													17	150					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39978721	39978721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39978721C>T	ENST00000373257.3	+	7	877	c.786C>T	c.(784-786)tcC>tcT	p.S262S		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	262					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				GGCCCGAGTCCTCAGTGGTCC	0.627000													3	11					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31608171	31608171	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31608171T>G	ENST00000170150.3	+	12	1313	c.1118T>G	c.(1117-1119)gTg>gGg	p.V373G		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	373						extracellular region	lipid binding										GTGTCCAAGGTGAAGCTTCAG	0.612000													17	61					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11177099	11177099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11177099G>A	ENST00000361445.4	-	50	7054	c.6978C>T	c.(6976-6978)gtC>gtT	p.V2326V	MTOR_ENST00000376838.1_Silent_p.V531V	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2326	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CCATTGACATGACCGCTAAAG	0.378000													49	116					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533134	169533134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169533134C>T	ENST00000449804.2	+	1	218	c.173C>T	c.(172-174)aCc>aTc	p.T58I	FOXI1_ENST00000306268.6_Missense_Mutation_p.T58I	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	58	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TATGGGGCCACCCCCAACCCC	0.682000									Pendred syndrome				9	19					0	0	1	0	0
CD81	975	broad.mit.edu	37	11	2415403	2415403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2415403C>T	ENST00000263645.5	+	3	516	c.260C>T	c.(259-261)tCc>tTc	p.S87F	CD81_ENST00000381036.3_Missense_Mutation_p.S125F|CD81_ENST00000492627.1_Missense_Mutation_p.S16F|CD81_ENST00000526072.1_Missense_Mutation_p.S16F|CD81_ENST00000524805.1_3'UTR|CD81_ENST00000481687.1_Missense_Mutation_p.S93F	NM_004356.3	NP_004347.1	P60033	CD81_HUMAN	CD81 molecule	87					activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding			endometrium(1)|lung(3)|skin(1)	5		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		ATCCAGGAATCCCAGTGCCTG	0.677000													7	40					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4909091	4909091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4909091C>T	ENST00000396658.4	+	4	1201	c.498C>T	c.(496-498)acC>acT	p.T166T	UBN1_ENST00000262376.6_Silent_p.T166T|UBN1_ENST00000590769.1_Silent_p.T166T|UBN1_ENST00000545171.1_Silent_p.T166T	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	166	Sufficient for interaction with HIRA.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						ACTCGGGAACCCTGCAGTTTA	0.388000													13	105					0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	56000536	56000536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56000536C>T	ENST00000313264.4	-	1	201	c.126G>A	c.(124-126)atG>atA	p.M42I		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TGACATTCTTCATGTTGAAAT	0.358000													28	61					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178417660	178417660	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178417660G>A	ENST00000231188.5	-	4	1123	c.945C>T	c.(943-945)ccC>ccT	p.P315P	GRM6_ENST00000517717.1_Silent_p.P315P	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	315					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GGCTCAAGATGGGTGAGGTCT	0.667000													3	15					0	0	1	0	0
GZMH	2999	broad.mit.edu	37	14	25076911	25076911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:25076911C>T	ENST00000216338.4	-	3	290	c.246G>A	c.(244-246)caG>caA	p.Q82Q	RP11-104E19.1_ENST00000557736.1_RNA|RP11-104E19.1_ENST00000555300.1_RNA|GZMH_ENST00000557220.2_Intron|GZMH_ENST00000382548.4_Silent_p.Q82Q	NM_033423.3	NP_219491.1	P20718	GRAH_HUMAN	granzyme H (cathepsin G-like 2, protein h-CCPX)	82	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)	12				GBM - Glioblastoma multiforme(265;0.0267)		GGGTCCGCTCCTGTTCCTTGA	0.542000													56	151					0	0	1	0	0
C6orf223	221416	broad.mit.edu	37	6	43968437	43968437	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43968437G>A	ENST00000336600.5	+	1	101	c.81_splice	c.e1+1	p.R27_splice	RP5-1120P11.1_ENST00000607590.1_RNA|C6orf223_ENST00000439969.2_Splice_Site_p.R27_splice|C6orf223_ENST00000448947.2_3'UTR|RP5-1120P11.1_ENST00000422059.1_RNA	NM_001171992.1|NM_153246.4	NP_001165463.1|NP_694978.2	Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	27										central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			TTCTGCGGAGGGTGAGACTGA	0.632000													3	8					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29278138	29278138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29278138G>A	ENST00000266943.6	-	5	1612	c.1243C>T	c.(1243-1245)Cct>Tct	p.P415S	SLC46A3_ENST00000380814.4_Missense_Mutation_p.P415S|SLC46A3_ENST00000475385.1_5'UTR	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	415					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		GTGAAGCCAGGGTACCAAGCA	0.408000													17	51					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50159027	50159027	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50159027G>A	ENST00000371564.3	-	1	231	c.12C>T	c.(10-12)ccC>ccT	p.P4P	NFATC2_ENST00000414705.1_Intron|NFATC2_ENST00000396009.3_Silent_p.P4P	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	4					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GCTGCCGCTCGGGGGCGTTCA	0.751000													3	11					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106320527	106320527	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106320527G>A	ENST00000390559.2	-	0	1282																											CTTGTCCACGGTCCTCTCGGT	0.627000													27	70					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68748123	68748123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68748123C>T	ENST00000309106.3	-	1	332	c.333G>A	c.(331-333)gtG>gtA	p.V111V		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	111						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGCTCAGGCCCACTGTGTAGG	0.592000													7	53					0	0	1	0	0
RGS5	8490	broad.mit.edu	37	1	163122409	163122409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:163122409G>A	ENST00000313961.5	-	4	592	c.315C>T	c.(313-315)tcC>tcT	p.S105S	RGS5_ENST00000527988.1_5'UTR|RGS5_ENST00000367903.3_Silent_p.S125S|RGS5_ENST00000530507.1_Silent_p.S105S	NM_001254749.1|NM_003617.3	NP_001241678.1|NP_003608.1	O15539	RGS5_HUMAN	regulator of G-protein signaling 5	105	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity	p.S105S(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20			LUSC - Lung squamous cell carcinoma(543;0.187)			TCTTGGCAGGGGACTTGATCT	0.448000													72	272					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183710474	183710474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183710474G>A	ENST00000511685.1	+	25	5656	c.5533G>A	c.(5533-5535)Gga>Aga	p.G1845R	TENM3_ENST00000406950.2_Missense_Mutation_p.G1845R					teneurin transmembrane protein 3																		AGATTATGACGGACAGGGGAG	0.478000													10	22					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28273189	28273189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28273189C>T	ENST00000305242.5	-	5	698	c.606G>A	c.(604-606)aaG>aaA	p.K202K	ARMC4_ENST00000239715.3_Silent_p.K59K	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	202							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CTATATCCTTCTTCACCGTCA	0.338000													54	119					0	0	1	0	0
DEDD2	162989	broad.mit.edu	37	19	42713887	42713887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42713887G>A	ENST00000595337.1	-	4	641	c.554C>T	c.(553-555)cCc>cTc	p.P185L	DEDD2_ENST00000598727.1_Missense_Mutation_p.P185L|DEDD2_ENST00000593804.1_5'UTR|DEDD2_ENST00000596251.1_Missense_Mutation_p.P185L|DEDD2_ENST00000336034.4_Missense_Mutation_p.P180L	NM_001270614.1	NP_001257543.1	Q8WXF8	DEDD2_HUMAN	death effector domain containing 2	185					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(2)	5		Prostate(69;0.0704)				AGGTCTGGCGGGCTCTGACTG	0.672000													41	109					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632771	122632771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122632771C>T	ENST00000195173.4	-	15	2369	c.2066G>A	c.(2065-2067)cGa>cAa	p.R689Q	SEMA5B_ENST00000451055.2_Missense_Mutation_p.R743Q|SEMA5B_ENST00000357599.3_Missense_Mutation_p.R689Q			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	689	TSP type-1 1.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GCTGCAACTTCGCTGGCGGAC	0.682000													30	60					0	0	1	0	0
TSNAXIP1	55815	broad.mit.edu	37	16	67854817	67854817	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67854817C>T	ENST00000388833.3	+	3	438	c.61C>T	c.(61-63)Cga>Tga	p.R21*	TSNAXIP1_ENST00000561639.1_Nonsense_Mutation_p.R75*|TSNAXIP1_ENST00000562321.1_Intron|TSNAXIP1_ENST00000415766.3_Intron	NM_018430.2	NP_060900.2	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein 1	21					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|soft_tissue(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		TTTGCAAAATCGAAAACCCTG	0.582000													74	229					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37002154	37002154	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37002154G>A	ENST00000379242.3	+	9	1048	c.746G>A	c.(745-747)aGg>aAg	p.R249K	VIT_ENST00000401530.1_Missense_Mutation_p.R249K|VIT_ENST00000379241.3_Intron|VIT_ENST00000404084.1_Intron|VIT_ENST00000389975.3_Missense_Mutation_p.R249K|VIT_ENST00000497382.1_5'UTR	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	249						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				GGTATCCAAAGGCAAGATCCT	0.507000													25	33					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836195	142836195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142836195C>T	ENST00000291009.3	+	3	269	c.229C>T	c.(229-231)Cct>Tct	p.P77S		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	77						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		TAGCAGCATCCCTCTACAAGG	0.428000													30	90					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20782881	20782881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20782881C>T	ENST00000359062.3	+	6	1620	c.1580C>T	c.(1579-1581)tCc>tTc	p.S527F	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	527					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TCGCCCTGCTCCTCACCTCTC	0.453000													39	104					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159831822	159831822	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:159831822G>A	ENST00000297151.4	-	14	1845	c.1458C>T	c.(1456-1458)ctC>ctT	p.L486L		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	486					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTACCTCCATGAGGGTTTGAG	0.363000													4	45					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400019	89400019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89400019G>A	ENST00000439576.2	+	12	4577	c.4203G>A	c.(4201-4203)gaG>gaA	p.E1401E	ACAN_ENST00000352105.7_Silent_p.E1401E|ACAN_ENST00000559004.1_Silent_p.E1401E|ACAN_ENST00000561243.1_Silent_p.E1401E	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1401					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AAGTTCTAGAGACTACTGCCC	0.542000													104	165					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3236042	3236042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3236042C>T	ENST00000217939.6	-	6	5834	c.5680G>A	c.(5680-5682)Gct>Act	p.A1894T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1894	Ig-like C2-type 3.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTCATAAGAGCTCCTGGAGAA	0.408000													14	14					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167085308	167085308	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167085308G>A	ENST00000375387.4	-	22	4442	c.4102C>T	c.(4102-4104)Cgt>Tgt	p.R1368C	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1367C|SCN9A_ENST00000409672.1_Missense_Mutation_p.R1356C|SCN9A_ENST00000303354.6_Missense_Mutation_p.R1368C			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1367						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CATTCGGAACGATTTGGAACT	0.403000													54	205					0	0	1	0	0
CCDC113	29070	broad.mit.edu	37	16	58312481	58312481	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58312481C>T	ENST00000219299.4	+	8	1066	c.987C>T	c.(985-987)atC>atT	p.I329I	CCDC113_ENST00000443128.2_Silent_p.I275I	NM_014157.3	NP_054876.2	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113	329						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						GGGAGAAGATCTTAAATGCGG	0.572000													19	45					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284387	52284387	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52284387G>A	ENST00000301190.6	+	5	884	c.657G>A	c.(655-657)gtG>gtA	p.V219V	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Silent_p.V94V|ANKRD33_ENST00000538991.1_Silent_p.V25V	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	94										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		TGACAGCAGTGGACCCTGTTC	0.617000													8	16					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189012603	189012603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189012603G>A	ENST00000512729.1	-	7	1462	c.1088C>T	c.(1087-1089)cCa>cTa	p.P363L	TRIML2_ENST00000326754.3_Missense_Mutation_p.P388L	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	363	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GTCTCCATTTGGGATACAGAG	0.453000													17	104					0	0	1	0	0
BSND	7809	broad.mit.edu	37	1	55474208	55474208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55474208G>A	ENST00000371265.4	+	4	1124	c.870G>A	c.(868-870)aaG>aaA	p.K290K		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	290						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						AACCTGAGAAGGAAGAGGAAG	0.582000													21	73					0	0	1	0	0
DENND6A	201627	broad.mit.edu	37	3	57620487	57620487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:57620487G>A	ENST00000311128.5	-	13	1212	c.1142C>T	c.(1141-1143)cCt>cTt	p.P381L	RP11-755B10.2_ENST00000470427.1_RNA	NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		AACCTGCTTAGGAATTTCACC	0.254000													7	21					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55929392	55929392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55929392C>T	ENST00000244728.5	-	24	2553	c.2156G>A	c.(2155-2157)gGa>gAa	p.G719E	COL21A1_ENST00000535941.1_Missense_Mutation_p.G719E|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.G119E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G716E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	719	Collagen-like 4.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CCCTGGAATTCCCTGTCTTCC	0.323000													4	11					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114181785	114181785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:114181785G>A	ENST00000393081.1	+	16	1775	c.1468G>A	c.(1468-1470)Gaa>Aaa	p.E490K	ACSL5_ENST00000433418.1_Missense_Mutation_p.E490K|ACSL5_ENST00000356116.1_Missense_Mutation_p.E546K|ACSL5_ENST00000354273.4_Missense_Mutation_p.E490K|ACSL5_ENST00000369410.3_Missense_Mutation_p.E272K|ACSL5_ENST00000354655.4_Missense_Mutation_p.E490K	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	490					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		AGTGAATAATGAAGGAGAGGT	0.473000													28	59					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39535000	39535000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39535000G>A	ENST00000265707.5	+	15	1621	c.1576G>A	c.(1576-1578)Gaa>Aaa	p.E526K	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.E502K	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	526	Cys-rich.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TTCTCTGCATGAAAGATCTGA	0.308000													16	56					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	31144214	31144214	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:31144214C>T	ENST00000543491.1	+	3	3511	c.3511C>T	c.(3511-3513)Cag>Tag	p.Q1171*				O60245	PCDH7_HUMAN	protocadherin 7	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						GAAGAAGAGCCAGCCTAAACT	0.562000													48	119					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74644535	74644535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:74644535G>A	ENST00000541184.1	-	7	1138	c.661C>T	c.(661-663)Ctc>Ttc	p.L221F	ZDHHC15_ENST00000373367.3_Missense_Mutation_p.L230F|ZDHHC15_ENST00000373361.3_3'UTR	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	230						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						TAACCAAAGAGAATCACAAGG	0.378000													15	13					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167247009	167247009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167247009G>A	ENST00000308378.3	-	10	1486	c.1181C>T	c.(1180-1182)tCa>tTa	p.S394L	WDR49_ENST00000453925.2_Missense_Mutation_p.S458L|WDR49_ENST00000479765.1_Intron|WDR49_ENST00000476376.1_Missense_Mutation_p.S219L	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	394										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TCCTCCACATGATACCAGGTT	0.383000													27	48					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663181	34663181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34663181G>A	ENST00000488417.1	+	2	796	c.676G>A	c.(676-678)Ggc>Agc	p.G226S	C1orf94_ENST00000373374.3_Missense_Mutation_p.G36S	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	36							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AGAGGACAGGGGCCGCATCCT	0.542000													21	57					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711165	41711165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41711165C>T	ENST00000400454.1	-	7	1865	c.1388G>A	c.(1387-1389)gGg>gAg	p.G463E		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	463	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GACCACGTTCCCCTCCGACGT	0.612000													27	54					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2193006	2193006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2193006G>A	ENST00000381178.1	-	1	29	c.11C>T	c.(10-12)cCc>cTc	p.P4L	TH_ENST00000352909.3_Missense_Mutation_p.P4L|TH_ENST00000381175.1_Missense_Mutation_p.P4L|TH_ENST00000333684.5_Missense_Mutation_p.P4L	NM_199292.2	NP_954986.2	P07101	TY3H_HUMAN	tyrosine hydroxylase	4					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(7)|skin(1)	11		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	GGTGGCGTCGGGGGTGGGCAT	0.662000													16	35					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60902947	60902947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60902947G>A	ENST00000252999.3	-	36	4838	c.4772C>T	c.(4771-4773)cCc>cTc	p.P1591L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1591	Laminin EGF-like 15.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCTGTGAGGGGGTCACACAC	0.662000													27	45					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133899584	133899584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133899584C>T	ENST00000220616.4	+	9	2007	c.1967C>T	c.(1966-1968)cCa>cTa	p.P656L	TG_ENST00000377869.1_Missense_Mutation_p.P656L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	656	Thyroglobulin type-1 5.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGTGGACAGCCAAGGTGCCCC	0.547000													17	47					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28586965	28586965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28586965G>A	ENST00000434452.1	-	12	1950	c.1796C>T	c.(1795-1797)cCt>cTt	p.P599L	DSC3_ENST00000360428.4_Missense_Mutation_p.P599L	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	599	Cadherin 5.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			AGGTTCATCAGGATCAACAGC	0.368000													28	45					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43610138	43610138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43610138C>T	ENST00000360835.3	-	16	2137	c.2011G>A	c.(2011-2013)Ggg>Agg	p.G671R		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	671					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				AGACCAAGCCCGTCGCTGCTG	0.647000													14	30					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	140781	140781	+	Missense_Mutation	SNP	G	G	A	rs143686104	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140781G>A	ENST00000283426.6	+	1	409	c.359G>A	c.(358-360)gGg>gAg	p.G120E		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	120					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CAAGCTGTGGGGACCCCAAAC	0.662000													11	27					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72301234	72301234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72301234G>A	ENST00000263563.6	+	17	2333	c.2065G>A	c.(2065-2067)Ggt>Agt	p.G689S		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CCCCGAGGTGGGTGAGGAGGA	0.632000													8	24					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127686617	127686617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127686617C>T	ENST00000508053.1	-	27	3729	c.2755G>A	c.(2755-2757)Gaa>Aaa	p.E919K	FBN2_ENST00000262464.4_Missense_Mutation_p.E919K|FBN2_ENST00000508989.1_Missense_Mutation_p.E886K			P35556	FBN2_HUMAN	fibrillin 2	919	TB 4.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCACAGCATTCAGATTTCAGA	0.552000													28	80					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170863617	170863617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170863617C>T	ENST00000272793.5	+	28	4197	c.4147C>T	c.(4147-4149)Cct>Tct	p.P1383S	UBR3_ENST00000418381.1_Missense_Mutation_p.P1383S|UBR3_ENST00000392631.1_Missense_Mutation_p.P204S			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1383					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						GGAAAATAACCCTTGGCAACG	0.483000													11	40					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26673526	26673526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26673526C>T	ENST00000288710.2	+	13	1740	c.1666C>T	c.(1666-1668)Cac>Tac	p.H556Y		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		ATATCGAGCTCACCGTTTATC	0.383000													27	111					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42693479	42693479	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42693479G>A	ENST00000372999.1	+	7	1010	c.816G>A	c.(814-816)cgG>cgA	p.R272R	TOX2_ENST00000435864.2_Silent_p.R192R|TOX2_ENST00000341197.3_Silent_p.R314R|TOX2_ENST00000358131.5_Intron|TOX2_ENST00000423191.1_Silent_p.R272R	NM_032883.2	NP_116272.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CAGCCTACCGGGCTAGCCTCG	0.562000													31	105					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34029359	34029359	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:34029359G>A	ENST00000346562.2	+	4	479	c.405G>A	c.(403-405)caG>caA	p.Q135Q	NPAS3_ENST00000357798.5_Silent_p.Q154Q|NPAS3_ENST00000548645.1_Silent_p.Q137Q|NPAS3_ENST00000547068.1_Silent_p.Q63Q|NPAS3_ENST00000551008.1_Silent_p.Q65Q|NPAS3_ENST00000341321.4_Silent_p.Q167Q|NPAS3_ENST00000356141.4_Silent_p.Q167Q|NPAS3_ENST00000551492.1_Silent_p.Q172Q	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CACTAAATCAGGAAGGAAAAT	0.338000													23	56					0	0	1	0	0
NRL	4901	broad.mit.edu	37	14	24552052	24552052	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24552052G>A	ENST00000561028.1	-	2	325	c.6C>T	c.(4-6)gcC>gcT	p.A2A	NRL_ENST00000397002.2_Silent_p.A2A|NRL_ENST00000396997.1_Silent_p.A2A			P54845	NRL_HUMAN	neural retina leucine zipper	2					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding			lung(2)	2				GBM - Glioblastoma multiforme(265;0.0181)		TGGGGGGCAGGGCCATTCTGG	0.602000													10	46					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7621800	7621800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7621800G>A	ENST00000256861.6	-	9	1414	c.1336C>T	c.(1336-1338)Ctg>Ttg	p.L446L	ITIH5_ENST00000298441.6_Silent_p.L232L|ITIH5_ENST00000446830.2_Silent_p.L228L|ITIH5_ENST00000397146.2_Silent_p.L446L|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Silent_p.L446L	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	446	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.L446L(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TTCTCCAGCAGCCTGAAGTCC	0.617000													21	58					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150647458	150647458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150647458C>T	ENST00000392968.2	-	7	3028	c.1908G>A	c.(1906-1908)ctG>ctA	p.L636L	KCNH2_ENST00000430723.3_Silent_p.L732L|KCNH2_ENST00000262186.5_Silent_p.L732L|KCNH2_ENST00000330883.4_Silent_p.L392L			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	732					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GTGAGCGGTTCAGGTGCAGGC	0.657000													28	55					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400660	85400660	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85400660C>T	ENST00000258888.5	+	6	3464	c.3297C>T	c.(3295-3297)ttC>ttT	p.F1099F		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1099					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGCCACCTTCCTGCCCTCTG	0.622000													22	76					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7011416	7011416	+	Silent	SNP	C	C	T	rs148253534		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:7011416C>T	ENST00000389658.3	-	25	3663	c.3570G>A	c.(3568-3570)acG>acA	p.T1190T		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1190	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCCCTCGGTCGTGCCCCTCA	0.597000													4	8					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408205	29408205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29408205G>A	ENST00000444197.2	+	1	1123	c.413G>A	c.(412-414)cGg>cAg	p.R138Q	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	138			R -> W (in dbSNP:rs17177646).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CTGAGCCACCGGGTGTGTCTA	0.637000													23	51					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873661	36873661	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36873661C>T	ENST00000301807.6	-	21	7528	c.5631G>A	c.(5629-5631)tgG>tgA	p.W1877*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.W2427*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.W1877*	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2427					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TGACATTCTTCCAGAGGCGGG	0.522000													36	100					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12704715	12704715	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12704715C>T	ENST00000376221.1	+	1	150	c.150C>T	c.(148-150)ttC>ttT	p.F50F		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	50						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		ATTGCATATTCCTCTACCTGG	0.507000													58	174					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990484	63990484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:63990484C>T	ENST00000370658.5	-	5	584	c.551G>A	c.(550-552)aGa>aAa	p.R184K	LGSN_ENST00000370657.4_Silent_p.K324K	NM_001143940.1|NM_016571.2	NP_001137412.1|NP_057655.2	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	348					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	ACATGTTTTTCTTCCTATCGA	0.453000													12	76					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449242	104449242	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104449242G>A	ENST00000361820.3	-	2	1540	c.940C>T	c.(940-942)Cag>Tag	p.Q314*		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	314					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTCTCAAGCTGGATCTGTAGG	0.488000													26	50					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116930318	116930318	+	Silent	SNP	C	C	T	rs148339655		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116930318C>T	ENST00000356083.3	+	3	874	c.483C>T	c.(481-483)ctC>ctT	p.L161L		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	161	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						ACCTGGCCCTCGAGCTCCGAG	0.701000													14	37					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104099448	104099448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104099448C>T	ENST00000388887.2	+	37	4143	c.3939C>T	c.(3937-3939)ttC>ttT	p.F1313F		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1313					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CCTCCTATTTCATGGGAAGAC	0.403000													14	46					0	0	1	0	0
FAM71D	161142	broad.mit.edu	37	14	67664956	67664956	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:67664956G>A	ENST00000556046.1	+	3	302	c.78G>A	c.(76-78)ccG>ccA	p.P26P				Q8N9W8	FA71D_HUMAN	family with sequence similarity 71, member D	26										breast(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(1)	13		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		CCCATGATCCGAGAGATCTTC	0.428000													55	116					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188426	7188426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7188426C>T	ENST00000542285.1	-	11	1521	c.1372G>A	c.(1372-1374)Gaa>Aaa	p.E458K				P00736	C1R_HUMAN	complement component 1, r subcomponent	510					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTTTGCGCTTCGTGTTCCTTG	0.612000													12	56					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114279872	114279872	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114279872C>T	ENST00000357077.4	+	38	10151	c.10098C>T	c.(10096-10098)acC>acT	p.T3366T	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.T3333T|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3333					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCTAGACACCTCTGTCCAGA	0.458000													13	128					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90020813	90020813	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90020813G>A	ENST00000268122.4	-	7	1115	c.1047C>T	c.(1045-1047)atC>atT	p.I349I	RHCG_ENST00000544600.1_Silent_p.I349I	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	349					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					TGCCGCCTATGATGCCAGGAA	0.582000													6	73					0	0	1	0	0
AKNAD1	254268	broad.mit.edu	37	1	109377600	109377600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109377600C>T	ENST00000370001.3	-	8	1883	c.1615G>A	c.(1615-1617)Ggg>Agg	p.G539R	AKNAD1_ENST00000357393.4_Missense_Mutation_p.G246R|AKNAD1_ENST00000369995.3_Missense_Mutation_p.G539R|AKNAD1_ENST00000369994.1_Intron	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	539										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						TCCTGCGGCCCTCCTTGGGGT	0.657000													27	68					0	0	1	0	0
MCU	90550	broad.mit.edu	37	10	74619011	74619011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74619011C>T	ENST00000536019.1	+	3	595	c.150C>T	c.(148-150)ttC>ttT	p.F50F	MCU_ENST00000357157.6_Silent_p.F99F|MCU_ENST00000373053.3_Silent_p.F99F	NM_001270680.1	NP_001257609.1	Q8NE86	MCU_HUMAN	mitochondrial calcium uniporter	99					elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	14						GCTGTCAGTTCACACTCAAGC	0.438000													64	153					0	0	1	0	0
CLEC1A	51267	broad.mit.edu	37	12	10241809	10241809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10241809G>A	ENST00000315330.4	-	2	190	c.128C>T	c.(127-129)cCc>cTc	p.P43L	CLEC1A_ENST00000457018.2_Intron|CLEC1A_ENST00000420265.2_Intron	NM_016511.2	NP_057595.2	Q8NC01	CLC1A_HUMAN	C-type lectin domain family 1, member A	43					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	23						CGTTGAAGAGGGAGCCCTGTG	0.527000													8	40					0	0	1	0	0
SRP68	6730	broad.mit.edu	37	17	74044000	74044000	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74044000G>A	ENST00000307877.2	-	10	1290	c.1129C>T	c.(1129-1131)Caa>Taa	p.Q377*	SRP68_ENST00000542536.2_5'UTR|SRP68_ENST00000602720.1_Nonsense_Mutation_p.Q38*|SRP68_ENST00000539137.1_Nonsense_Mutation_p.Q339*|SRP68_ENST00000355113.5_Nonsense_Mutation_p.Q276*	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	377					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						TGCAAGTATTGAAGATTAGAC	0.284000													35	111					0	0	1	0	0
LUZP2	338645	broad.mit.edu	37	11	25004683	25004683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:25004683G>A	ENST00000533227.1	+	9	638	c.351G>A	c.(349-351)atG>atA	p.M117I	LUZP2_ENST00000336930.6_Missense_Mutation_p.M203I	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	203						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						AGTCACAGATGAAAGCAATGA	0.408000													60	138					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176659540	176659540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176659540C>T	ENST00000367662.3	+	5	3569	c.2405C>T	c.(2404-2406)cCg>cTg	p.P802L	PAPPA2_ENST00000367661.3_Missense_Mutation_p.P802L	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	802					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CCAGGGGCTCCGTTCACCAAC	0.567000													12	103					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069754	9069754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9069754G>A	ENST00000397910.4	-	3	17895	c.17692C>T	c.(17692-17694)Cca>Tca	p.P5898S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5900	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGAGTGTGGAAATCTCTGA	0.517000													26	92					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189852856	189852856	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189852856C>T	ENST00000304636.3	+	6	748	c.578C>T	c.(577-579)tCc>tTc	p.S193F	COL3A1_ENST00000317840.5_Missense_Mutation_p.S193F	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	193	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CATCCTGGTTCCCCTGTAAGT	0.398000													39	96					0	0	1	0	0
OR6C3	254786	broad.mit.edu	37	12	55726102	55726102	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55726102C>T	ENST00000379667.1	+	1	618	c.618C>T	c.(616-618)ttC>ttT	p.F206F		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						CTTTGCTGTTCACTTTGGCAT	0.368000													43	156					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125856770	125856770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125856770G>A	ENST00000393434.2	-	10	1459	c.1110C>T	c.(1108-1110)ggC>ggT	p.G370G	ALDH1L1_ENST00000393431.2_Silent_p.G370G|ALDH1L1_ENST00000472186.1_Silent_p.G370G|ALDH1L1_ENST00000452905.2_Silent_p.G269G|ALDH1L1_ENST00000273450.3_Silent_p.G380G	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	370	Acyl carrier.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CTAACTCCAGGCCATCACACA	0.567000													20	60					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801196	140801196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140801196C>T	ENST00000398587.2	+	1	435	c.402C>T	c.(400-402)ttC>ttT	p.F134F	PCDHGA11_ENST00000518882.1_Silent_p.F134F|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCCAGCTTCCAGGAGGACG	0.473000													7	19					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42127274	42127274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42127274C>T	ENST00000382448.4	+	3	334	c.325C>T	c.(325-327)Ctg>Ttg	p.L109L	JMJD7_ENST00000397299.4_Silent_p.L109L|JMJD7-PLA2G4B_ENST00000476036.1_3'UTR|JMJD7-PLA2G4B_ENST00000342159.4_Silent_p.L109L|JMJD7-PLA2G4B_ENST00000542534.1_Silent_p.L109L|JMJD7_ENST00000408047.1_Silent_p.L10L	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		0					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						CCGCCTGCCCCTGAGCTTCGT	0.652000													47	98					0	0	1	0	0
PANX2	56666	broad.mit.edu	37	22	50615914	50615914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50615914C>T	ENST00000395842.2	+	2	773	c.773C>T	c.(772-774)aCc>aTc	p.T258I	PANX2_ENST00000159647.5_Missense_Mutation_p.T258I	NM_052839.3	NP_443071.2	Q96RD6	PANX2_HUMAN	pannexin 2	258					protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)	7		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		AACGAGTTCACCTGCGCGCTG	0.692000													4	9					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72300277	72300277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72300277C>T	ENST00000334456.5	-	12	1126	c.881G>A	c.(880-882)gGa>gAa	p.G294E	PDE2A_ENST00000540345.1_Missense_Mutation_p.G285E|PDE2A_ENST00000418754.2_Missense_Mutation_p.G179E|PDE2A_ENST00000444035.2_Missense_Mutation_p.G285E|PDE2A_ENST00000544570.1_Missense_Mutation_p.G287E|PDE2A_ENST00000376450.3_Intron	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	294	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GCCCAGGCATCCTGTCAACTA	0.577000													6	17					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135015029	135015029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:135015029G>A	ENST00000304613.3	+	17	3035	c.3014G>A	c.(3013-3015)aGg>aAg	p.R1005K	KNDC1_ENST00000368572.2_Missense_Mutation_p.R1007K|KNDC1_ENST00000368571.2_Missense_Mutation_p.R940K			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1005					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GCCATGGCCAGGACCAGCAGC	0.627000													49	110					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20682893	20682893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20682893G>A	ENST00000404938.2	+	6	1053	c.401G>A	c.(400-402)cGa>cAa	p.R134Q		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	318	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						ACTGCAGCACGACAGACCAAG	0.418000													15	27					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159900508	159900508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159900508C>T	ENST00000368094.1	-	14	1984	c.1787G>A	c.(1786-1788)aGc>aAc	p.S596N	IGSF9_ENST00000493195.1_5'UTR|IGSF9_ENST00000361509.3_Missense_Mutation_p.S580N	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	596	Fibronectin type-III 1.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GACGATTTCGCTGAAGGGACC	0.602000													4	59					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57924639	57924639	+	Missense_Mutation	SNP	C	C	T	rs138018355	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57924639C>T	ENST00000574161.1	+	7	805	c.686C>T	c.(685-687)tCg>tTg	p.S229L	GCOM1_ENST00000380561.2_Missense_Mutation_p.S198L|GCOM1_ENST00000572390.1_Missense_Mutation_p.S229L|GCOM1_ENST00000380560.2_Missense_Mutation_p.S160L|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Missense_Mutation_p.S229L|GCOM1_ENST00000587652.1_Missense_Mutation_p.S229L|GCOM1_ENST00000396180.1_Missense_Mutation_p.S198L|MYZAP_ENST00000267853.5_Missense_Mutation_p.S229L|GCOM1_ENST00000380568.3_Missense_Mutation_p.S229L|MYZAP_ENST00000380565.4_Missense_Mutation_p.S229L	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		229					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						TAGGTGGAATCGTCCCAAGAA	0.517000													43	113					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16138400	16138400	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16138400C>T	ENST00000399408.2	+	8	1078	c.903C>T	c.(901-903)atC>atT	p.I301I	ABCC1_ENST00000349029.5_Silent_p.I301I|ABCC1_ENST00000345148.5_Silent_p.I301I|ABCC1_ENST00000346370.5_Silent_p.I301I|ABCC1_ENST00000399410.3_Silent_p.I301I|ABCC1_ENST00000351154.5_Silent_p.I301I			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	301					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AGGCTTTGATCGTCAAGTCCC	0.532000													24	62					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707846	50707846	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50707846G>A	ENST00000330943.4	-	4	593	c.422C>T	c.(421-423)cCc>cTc	p.P141L	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	141	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						GTGCTTCCTGGGAAACTCCAC	0.602000													7	58					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961518	73961518	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73961518G>A	ENST00000373468.1	-	3	3525	c.2874C>T	c.(2872-2874)ctC>ctT	p.L958L	KIAA2022_ENST00000055682.5_Silent_p.L958L			Q5QGS0	K2022_HUMAN	KIAA2022	958					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						CATCAGATGGGAGTTGGGTAT	0.423000													13	105					0	0	1	0	0
FFAR1	2864	broad.mit.edu	37	19	35843221	35843221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35843221C>T	ENST00000246553.2	+	1	777	c.767C>T	c.(766-768)tCc>tTc	p.S256F		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	256					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	CTAGGAGGCTCCTGGCGGAAG	0.642000													2	0					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603770	5603770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5603770G>A	ENST00000423158.3	+	2	641	c.429G>A	c.(427-429)gcG>gcA	p.A143A	NTF3_ENST00000331010.6_Silent_p.A130A|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	130					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						CCGTGGTGGCGAACAGAACAT	0.602000													20	82					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600189	92600189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92600189G>A	ENST00000298047.6	+	21	11958	c.11941G>A	c.(11941-11943)Ggc>Agc	p.G3981S	FAT3_ENST00000525166.1_Missense_Mutation_p.G3831S|FAT3_ENST00000533797.1_Missense_Mutation_p.G316S|FAT3_ENST00000409404.2_Missense_Mutation_p.G3981S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3981	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGTGCTCAGCGGCTTCCAGGG	0.617000										TCGA Ovarian(4;0.039)			4	6					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141370273	141370273	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:141370273A>C	ENST00000389328.4	-	9	1679	c.1665T>G	c.(1663-1665)gcT>gcG	p.A555A	TRAPPC9_ENST00000389327.3_Silent_p.A448A|TRAPPC9_ENST00000438773.2_Silent_p.A457A	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	457					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						TCTGGACCGCAGCCCAGCCTC	0.512000													22	36					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43668391	43668391	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43668391C>T	ENST00000564079.1	+	2	414	c.174C>T	c.(172-174)ttC>ttT	p.F58F	TUBGCP4_ENST00000570081.1_3'UTR|TUBGCP4_ENST00000260383.7_Silent_p.F58F	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	58					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton	p.F58L(1)		breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		TCACTGAGTTCATTGAACAGT	0.542000											OREG0023088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	89					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39549961	39549961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:39549961G>A	ENST00000567887.1	+	1	228	c.71G>A	c.(70-72)cGa>cAa	p.R24Q	MACF1_ENST00000484793.1_Missense_Mutation_p.R24Q|MACF1_ENST00000602421.1_Missense_Mutation_p.R24Q|MACF1_ENST00000545844.1_Missense_Mutation_p.R24Q|MACF1_ENST00000539005.1_Missense_Mutation_p.R24Q|MACF1_ENST00000372915.3_Missense_Mutation_p.R24Q|MACF1_ENST00000361689.2_Missense_Mutation_p.R24Q|MACF1_ENST00000317713.7_Missense_Mutation_p.R24Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	24	Actin-binding.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CGGAGTGAGCGATCTTACAGG	0.627000													24	59					0	0	1	0	0
WNT10A	80326	broad.mit.edu	37	2	219754737	219754737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219754737C>T	ENST00000258411.3	+	3	1041	c.408C>T	c.(406-408)atC>atT	p.I136I	WNT10A_ENST00000483911.1_3'UTR	NM_025216.2	NP_079492.2	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family, member 10A	136					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|cervix(1)|endometrium(2)|lung(6)|skin(2)	12		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTACGCCATCGCAGCAGCTG	0.617000													12	88					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169539941	169539941	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169539941C>T	ENST00000340806.6	+	1	232	c.232C>T	c.(232-234)Ctg>Ttg	p.L78L		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	78										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						GGTCCTCTACCTGGATAAGAA	0.512000													43	93					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929783	121929783	+	Missense_Mutation	SNP	C	C	T	rs145920249		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:121929783C>T	ENST00000265922.3	-	8	2326	c.1865G>A	c.(1864-1866)cGg>cAg	p.R622Q	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		622					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						TAGCCGAGTCCGACTACGTAG	0.532000													62	103					0	0	1	0	0
DIRC2	84925	broad.mit.edu	37	3	122598136	122598136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122598136C>T	ENST00000261038.5	+	9	1746	c.1348C>T	c.(1348-1350)Ccc>Tcc	p.P450S		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	450					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		CTGGTGCCTTCCCGGGTCGTG	0.458000													136	268					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29938169	29938169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:29938169G>A	ENST00000378993.1	+	8	1688	c.1015G>A	c.(1015-1017)Gga>Aga	p.G339R	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.G339R	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	339	Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TGTTGAAAATGGAAATGGACG	0.433000													42	25					0	0	1	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45971094	45971094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45971094G>A	ENST00000391621.1	-	1	294	c.248C>T	c.(247-249)tCt>tTt	p.S83F	KRTAP10-2_ENST00000498210.1_Intron|TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198693.2	NP_941966.1	P60368	KR102_HUMAN	keratin associated protein 10-2	83	22 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|lung(4)|skin(1)	6						CTGGCAGCTAGACTGCTGGCA	0.692000													15	149					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7802241	7802241	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:7802241G>A	ENST00000420658.1	-	10	1466	c.1194C>T	c.(1192-1194)atC>atT	p.I398I	AFAP1_ENST00000358461.2_Silent_p.I398I|AFAP1_ENST00000360265.4_Silent_p.I398I|AFAP1_ENST00000382543.3_Silent_p.I398I	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	398	PH 2.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						CCAAACCCGGGATCACCTCGC	0.542000													21	33					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432383	104432383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104432383C>T	ENST00000361820.3	-	3	2911	c.2311G>A	c.(2311-2313)Gag>Aag	p.E771K		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	771					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TAGATCTTCTCACCTACCATG	0.383000													39	71					0	0	1	0	0
CHFR	55743	broad.mit.edu	37	12	133428221	133428221	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:133428221C>G	ENST00000266880.7	-	13	1571	c.1508G>C	c.(1507-1509)cGt>cCt	p.R503P	CHFR_ENST00000537522.1_Missense_Mutation_p.R126P|CHFR_ENST00000315585.7_Missense_Mutation_p.R463P|CHFR_ENST00000443047.2_Missense_Mutation_p.R412P|CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000450056.2_Missense_Mutation_p.R492P|CHFR_ENST00000432561.2_Missense_Mutation_p.R504P			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	504					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		AGGGGCGACACGCGGGTCCTG	0.657000													58	93					0	0	1	0	0
ZRSR1	7310	broad.mit.edu	37	5	112227676	112227676	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:112227676G>A	ENST00000391338.1	+	1	364	c.340G>A	c.(340-342)Gaa>Aaa	p.E114K	REEP5_ENST00000379638.4_Intron|REEP5_ENST00000513339.1_Intron|SRP19_ENST00000512790.1_3'UTR|REEP5_ENST00000474542.2_Intron|REEP5_ENST00000545426.1_Intron|REEP5_ENST00000504247.1_Intron	NM_001204199.1	NP_001191128.1			zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1											breast(1)|skin(1)|stomach(2)	4						aaagttaaaggaacaatggaa	0.428000													9	32					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15535087	15535087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15535087G>A	ENST00000389282.4	-	9	4916	c.4703C>T	c.(4702-4704)cCa>cTa	p.P1568L	WIZ_ENST00000263381.6_Missense_Mutation_p.P711L|WIZ_ENST00000545156.1_Missense_Mutation_p.P882L|WIZ_ENST00000599686.2_Missense_Mutation_p.P752L|WIZ_ENST00000599910.1_Missense_Mutation_p.P885L			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1568						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						GACTCGGGGTGGGGGTTGCCG	0.647000													10	30					0	0	1	0	0
MTSS1	9788	broad.mit.edu	37	8	125565696	125565696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125565696C>T	ENST00000518547.1	-	14	2278	c.1805G>A	c.(1804-1806)gGa>gAa	p.G602E	NDUFB9_ENST00000522532.1_Intron|MTSS1_ENST00000524090.1_Missense_Mutation_p.G492E|MTSS1_ENST00000523587.1_5'UTR|MTSS1_ENST00000325064.5_Missense_Mutation_p.G606E|MTSS1_ENST00000431961.2_Missense_Mutation_p.G320E|MTSS1_ENST00000378017.3_Missense_Mutation_p.G577E|MTSS1_ENST00000354184.4_Missense_Mutation_p.G320E|MTSS1_ENST00000395508.2_Missense_Mutation_p.G376E	NM_014751.4	NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	602					actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TCCAATGGTTCCCCGGCGGAC	0.627000													18	35					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31779004	31779004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31779004C>T	ENST00000375654.4	-	2	935	c.746G>A	c.(745-747)aGg>aAg	p.R249K	HSPA1L_ENST00000417199.3_Missense_Mutation_p.R249K	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	249					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TTTGTGTTTCCTCTTGAACTC	0.592000													39	97					0	0	1	0	0
CHST5	23563	broad.mit.edu	37	16	75563854	75563854	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:75563854G>A	ENST00000336257.3	-	3	1823	c.429C>T	c.(427-429)ttC>ttT	p.F143F	RP11-77K12.7_ENST00000460606.1_3'UTR|CHST5_ENST00000541075.1_Silent_p.F149F	NM_024533.4	NP_078809.2	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	143					N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)	24						TTGCCCAGTTGAAAAAGGCGG	0.607000													33	72					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40594355	40594355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40594355C>T	ENST00000260402.3	-	6	737	c.488G>A	c.(487-489)gGg>gAg	p.G163E	PLCB2_ENST00000543785.2_Missense_Mutation_p.G163E|PLCB2_ENST00000456256.2_Missense_Mutation_p.G163E|PLCB2_ENST00000557821.1_Missense_Mutation_p.G163E	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	163					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CGGAATCTTCCCTTCAGAGTT	0.612000													16	216					0	0	1	0	0
OR51F1	256892	broad.mit.edu	37	11	4790832	4790832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4790832G>A	ENST00000380383.1	-	1	336	c.337C>T	c.(337-339)Ctt>Ttt	p.L113F	MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Missense_Mutation_p.L106F|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	106						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		AATCCATGAAGAAAAAACATC	0.443000													11	41					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227886796	227886796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227886796C>T	ENST00000396625.3	-	44	4391	c.4184G>A	c.(4183-4185)gGg>gAg	p.G1395E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1392E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1395	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCCAGGGAGCCCCATGGCTCC	0.522000													56	172					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19758335	19758335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19758335G>A	ENST00000357324.6	-	21	2822	c.2796C>T	c.(2794-2796)gaC>gaT	p.D932D	ATP13A1_ENST00000291503.5_Silent_p.D814D	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	932					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGCTCAGGCGGTCCTGCAGGG	0.637000													10	20					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106153205	106153205	+	Missense_Mutation	SNP	G	G	A	rs61732088	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106153205G>A	ENST00000369704.3	+	11	1780	c.1646G>A	c.(1645-1647)cGa>cAa	p.R549Q		NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	549								p.R549Q(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GAACAGCAGCGAATAGAAAAG	0.453000													14	33					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25448201	25448201	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25448201G>A	ENST00000424208.1	+	0	2047				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CAGCGCTGGAGGAGGACTTGT	0.647000													4	27					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179639748	179639748	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179639748G>A	ENST00000589042.1	-	29	6914	c.6690C>T	c.(6688-6690)ttC>ttT	p.F2230F	TTN_ENST00000342992.6_Silent_p.F2230F|TTN_ENST00000360870.5_Silent_p.F2230F|TTN_ENST00000591111.1_Silent_p.F2230F|TTN_ENST00000342175.6_Silent_p.F2184F|TTN_ENST00000359218.5_Silent_p.F2184F|TTN_ENST00000460472.2_Silent_p.F2184F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1966	Ig-like 11.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTATGGAGAGGAAGTGAACCT	0.388000													23	74					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72691309	72691309	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72691309C>T	ENST00000326165.6	-	7	910	c.799G>A	c.(799-801)Ggc>Agc	p.G267S	CD300LF_ENST00000469092.1_3'UTR|CD300LF_ENST00000343125.4_3'UTR|CD300LF_ENST00000301573.9_3'UTR|CD300LF_ENST00000464910.1_Missense_Mutation_p.G270S|RAB37_ENST00000340415.3_Intron|RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000583937.1_Missense_Mutation_p.G282S|CD300LF_ENST00000361254.4_3'UTR	NM_139018.3	NP_620587.2	Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	267						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						CTGAGGTGGCCCATGTTGCAG	0.607000													23	51					0	0	1	0	0
SP1	6667	broad.mit.edu	37	12	53775537	53775537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53775537C>T	ENST00000426431.2	+	2	141	c.81C>T	c.(79-81)gcC>gcT	p.A27A	SP1_ENST00000327443.4_Silent_p.A34A	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	34	Repressor domain.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GTGGTGGTGCCTTTTCACAGG	0.478000											OREG0021870	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	76					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154562857	154562857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154562857G>A	ENST00000368474.4	-	7	2498	c.2299C>T	c.(2299-2301)Cgc>Tgc	p.R767C	ADAR_ENST00000292205.5_Missense_Mutation_p.R810C|ADAR_ENST00000368471.3_Missense_Mutation_p.R472C	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	767	DRBM 3.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GGGAACCAGCGACCCCCAACT	0.522000													27	74					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243354563	243354563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:243354563G>A	ENST00000366542.1	-	8	916	c.865C>T	c.(865-867)Cca>Tca	p.P289S	CEP170_ENST00000366544.1_Missense_Mutation_p.P289S|CEP170_ENST00000366543.1_Missense_Mutation_p.P289S	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	289						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			ACCTTCCCTGGGGTACTGTCA	0.438000													4	20					0	0	1	0	0
STAM	8027	broad.mit.edu	37	10	17730032	17730032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:17730032C>T	ENST00000377524.3	+	5	519	c.304C>T	c.(304-306)Cct>Tct	p.P102S	STAM_ENST00000540523.1_5'UTR	NM_003473.3	NP_003464.1	Q92783	STAM1_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	102	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	26						ACAGGGTCATCCTAAAGTATG	0.294000													34	96					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655520	46655520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46655520C>T	ENST00000253255.5	-	1	3699	c.3700G>A	c.(3700-3702)Gtg>Atg	p.V1234M		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1234	PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AAAATAGTCACCAAGTAGCAT	0.443000													52	104					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640355	99640355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:99640355C>T	ENST00000547776.2	-	13	2043	c.2044G>A	c.(2044-2046)Gaa>Aaa	p.E682K	ANKS1B_ENST00000329257.7_Missense_Mutation_p.E682K|ANKS1B_ENST00000550833.1_5'UTR|ANKS1B_ENST00000547010.1_Missense_Mutation_p.E262K	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	682						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GTATGGTTTTCGAGTTGGTTG	0.428000													4	28					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44951664	44951664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44951664G>A	ENST00000296125.4	+	11	1478	c.1410G>A	c.(1408-1410)gaG>gaA	p.E470E		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	470					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CTGTAAAAGAGAACTTTCTTC	0.478000													34	68					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	89998001	89998001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:89998001G>A	ENST00000428670.3	-	16	3021	c.2565C>T	c.(2563-2565)ttC>ttT	p.F855F	ATP2B1_ENST00000261173.2_Silent_p.F855F|ATP2B1_ENST00000359142.3_Silent_p.F855F|ATP2B1_ENST00000348959.3_Silent_p.F855F|ATP2B1_ENST00000393164.2_Silent_p.F598F			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	855					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						GGAACTGAAGGAATTTTGAGA	0.383000													22	52					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42344686	42344686	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42344686C>T	ENST00000217026.4	+	14	2189	c.2062C>T	c.(2062-2064)Ctg>Ttg	p.L688L	MYBL2_ENST00000396863.4_Silent_p.L664L	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	688						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCTGGGCCGCCTGAAGCCCAG	0.627000													13	273					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63517538	63517538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63517538C>T	ENST00000377819.5	+	4	2760	c.2606C>T	c.(2605-2607)tCc>tTc	p.S869F	RTN3_ENST00000540798.1_Missense_Mutation_p.S757F|RTN3_ENST00000339997.4_Missense_Mutation_p.S850F|RTN3_ENST00000341307.2_Missense_Mutation_p.S73F|RTN3_ENST00000356000.3_Missense_Mutation_p.S92F|RTN3_ENST00000354497.4_Missense_Mutation_p.S73F|RTN3_ENST00000537981.1_Missense_Mutation_p.S73F	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	869	Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						ATGCTGCTTTCCCTGGCAGCT	0.468000													12	42					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151166599	151166599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151166599C>T	ENST00000282466.3	-	4	1169	c.1170G>A	c.(1168-1170)agG>agA	p.R390R		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	390					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAAGTGGCTCCTTTCTAGTA	0.413000													28	34					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39798741	39798741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39798741G>A	ENST00000248668.4	-	2	1847	c.1848C>T	c.(1846-1848)gcC>gcT	p.A616A		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	616						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CGACGGCGGGGGCAGCCTGGG	0.751000													4	15					0	0	1	0	0
RHBDL3	162494	broad.mit.edu	37	17	30648243	30648243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:30648243C>T	ENST00000269051.4	+	9	1224	c.1210C>T	c.(1210-1212)Ccc>Tcc	p.P404S	RHBDL3_ENST00000538145.1_Missense_Mutation_p.P396S|RHBDL3_ENST00000536287.1_Missense_Mutation_p.P306S	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	404					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				GCCGCCTCCCCCCTGAGGGCT	0.602000													20	18					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135202	156135202	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156135202G>A	ENST00000329476.3	+	2	600	c.111G>A	c.(109-111)gaG>gaA	p.E37E	NPY2R_ENST00000506608.1_Silent_p.E37E	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	37					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CTGACCCTGAGCCAGAGCTTA	0.483000													20	67					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108202275	108202275	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108202275C>T	ENST00000278616.4	+	51	8005	c.7620C>T	c.(7618-7620)gtC>gtT	p.V2540V	ATM_ENST00000452508.2_Silent_p.V2540V|C11orf65_ENST00000525729.1_Intron	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2540	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTCATGAAGTCCTCAATAATG	0.313000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			19	65					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533860	92533860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92533860G>A	ENST00000298047.6	+	9	7698	c.7681G>A	c.(7681-7683)Gaa>Aaa	p.E2561K	FAT3_ENST00000525166.1_Missense_Mutation_p.E2411K|FAT3_ENST00000409404.2_Missense_Mutation_p.E2561K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2561	Cadherin 23.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTAGACCGGGAAAACCCTCT	0.468000										TCGA Ovarian(4;0.039)			11	26					0	0	1	0	0
CASQ2	845	broad.mit.edu	37	1	116311050	116311050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:116311050G>A	ENST00000261448.5	-	1	352	c.113C>T	c.(112-114)tCc>tTc	p.S38F	CASQ2_ENST00000456138.2_Missense_Mutation_p.S38F	NM_001232.3	NP_001223.2	O14958	CASQ2_HUMAN	calsequestrin 2 (cardiac muscle)	38					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	18	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GTTCTTCTCGGAAAGACTTAC	0.438000													92	61					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764208	92764208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92764208C>T	ENST00000318238.4	-	5	2293	c.1077G>A	c.(1075-1077)cgG>cgA	p.R359R	SAMD9L_ENST00000411955.1_Silent_p.R359R|SAMD9L_ENST00000437805.1_Silent_p.R359R	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	359										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AATCTACATCCCGTTGCTTGG	0.368000													33	211					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545533	186545533	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186545533C>T	ENST00000431808.1	-	14	1601	c.1038G>A	c.(1036-1038)cgG>cgA	p.R346R	SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000355634.5_Silent_p.R446R|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000418609.1_Silent_p.R250R|SORBS2_ENST00000284776.7_Silent_p.R346R			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	346						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TTGGTGAGTCCCGAGGGACAT	0.502000													25	69					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7847480	7847480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7847480G>A	ENST00000328375.1	-	1	39	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AACCCCAAAAGAGTAAACTCT	0.343000													6	59					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51696896	51696896	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51696896C>T	ENST00000267012.4	-	3	253	c.192G>A	c.(190-192)ctG>ctA	p.L64L	BIN2_ENST00000544402.1_Silent_p.L38L|BIN2_ENST00000452142.2_Silent_p.L64L|BIN2_ENST00000604560.1_Silent_p.L37L	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	64	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						GGAAGTTCTTCAGGTCCTTGT	0.438000													22	104					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56953494	56953494	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56953494G>A	ENST00000504904.3	-	7	1589	c.870C>T	c.(868-870)ttC>ttT	p.F290F	ZNF667_ENST00000292069.6_Silent_p.F290F|ZNF667_ENST00000342634.3_Silent_p.F418F|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		ATTTCTTTTTGAAGCCTCTCC	0.358000													13	135					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3318208	3318208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3318208C>T	ENST00000336727.3	+	2	1215	c.311C>T	c.(310-312)tCc>tTc	p.S104F	RGS12_ENST00000543385.1_Missense_Mutation_p.S104F|RGS12_ENST00000382788.3_Missense_Mutation_p.S104F|RGS12_ENST00000344733.5_Missense_Mutation_p.S104F	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	104						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CGCTTCGAATCCTGTTCCAGT	0.473000													25	84					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48677180	48677180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48677180C>T	ENST00000352832.5	+	16	3953	c.3581C>T	c.(3580-3582)cCc>cTc	p.P1194L	CACNA1G_ENST00000514717.1_Missense_Mutation_p.P1194L|CACNA1G_ENST00000515765.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000510366.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000512389.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000513964.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000513689.2_Missense_Mutation_p.P1217L|CACNA1G_ENST00000507609.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000505165.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000507336.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000507510.2_Missense_Mutation_p.P1217L|CACNA1G_ENST00000442258.2_Missense_Mutation_p.P1194L|CACNA1G_ENST00000514181.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000429973.2_Missense_Mutation_p.P1217L|CACNA1G_ENST00000514079.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000515165.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000510115.1_Missense_Mutation_p.P1194L|CACNA1G_ENST00000503485.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000358244.5_Missense_Mutation_p.P1194L|CACNA1G_ENST00000502264.1_Missense_Mutation_p.P1194L|CACNA1G_ENST00000416767.4_Missense_Mutation_p.P1217L|CACNA1G_ENST00000359106.5_Missense_Mutation_p.P1217L|CACNA1G_ENST00000354983.4_Missense_Mutation_p.P1194L|CACNA1G_ENST00000507896.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000515411.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000360761.4_Missense_Mutation_p.P1194L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1217					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGATGACCCCCCACTGGAT	0.667000													5	33					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51330299	51330299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51330299C>T	ENST00000326856.4	-	4	442	c.313G>A	c.(313-315)Gac>Aac	p.D105N	KLK15_ENST00000416184.1_Missense_Mutation_p.D106N|KLK15_ENST00000596931.1_Missense_Mutation_p.D105N|KLK15_ENST00000598239.1_Missense_Mutation_p.D106N|KLK15_ENST00000301421.2_Missense_Mutation_p.D106N	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	106	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.D106N(1)		breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		AACATGATGTCGTTGCGGTGG	0.687000													20	61					0	0	1	0	0
ARID3C	138715	broad.mit.edu	37	9	34627700	34627700	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34627700G>A	ENST00000378909.2	-	1	404	c.312C>T	c.(310-312)ttC>ttT	p.F104F		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CTACCTGCTTGAATTGTTCCT	0.622000													9	64					0	0	1	0	0
ZNF546	339327	broad.mit.edu	37	19	40520580	40520580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40520580C>T	ENST00000347077.4	+	7	1619	c.1403C>T	c.(1402-1404)cCc>cTc	p.P468L	ZNF546_ENST00000600094.1_Missense_Mutation_p.P442L|ZNF546_ENST00000596894.1_Intron	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GGTGAGAAACCCTATGAATGT	0.408000													27	85					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145567885	145567885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:145567885G>A	ENST00000296575.3	+	1	713	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K	HHIP-AS1_ENST00000512359.1_RNA|HHIP_ENST00000434550.2_Missense_Mutation_p.E20K	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	20						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GGGCTTCTTTGAAGGAGATGC	0.597000													21	84					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138208520	138208520	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:138208520T>C	ENST00000409968.1	+	15	3243	c.3065T>C	c.(3064-3066)aTt>aCt	p.I1022T	THSD7B_ENST00000272643.3_Missense_Mutation_p.I1022T|THSD7B_ENST00000413152.2_Missense_Mutation_p.I991T|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGAGTGAGAATTCGATCCAAA	0.403000													8	16					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9333638	9333638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9333638G>A	ENST00000261336.2	-	15	1808	c.1780C>T	c.(1780-1782)Cgt>Tgt	p.R594C	PZP_ENST00000381997.2_Missense_Mutation_p.R463C	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TCCACAGCACGAAGGGCACAG	0.587000													12	35					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66358116	66358116	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66358116C>G	ENST00000333861.3	-	1	2438	c.2371G>C	c.(2371-2373)Gag>Cag	p.E791Q		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	791										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						AAGATTAACTCTATCTCCTCC	0.517000													64	162					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51143224	51143224	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:51143224C>T	ENST00000414786.2	+	15	2015	c.1788C>T	c.(1786-1788)ctC>ctT	p.L596L	SHANK3_ENST00000445220.2_Silent_p.L611L|SHANK3_ENST00000262795.3_Silent_p.L626L			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	626										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		TGCAGTATCTCGAGTCGGTGG	0.667000													5	22					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488505	1488505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1488505C>T	ENST00000345913.4	+	9	1567	c.1476C>T	c.(1474-1476)ttC>ttT	p.F492F	TPO_ENST00000497517.2_3'UTR|TPO_ENST00000349624.3_Silent_p.F319F|TPO_ENST00000382198.1_Silent_p.F319F|TPO_ENST00000337415.3_Silent_p.F492F|TPO_ENST00000382201.3_Silent_p.F492F|TPO_ENST00000329066.4_Silent_p.F492F|TPO_ENST00000346956.3_Silent_p.F492F	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	492					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCTTCCGCTTCGGCCATGCCA	0.652000													12	51					0	0	1	0	0
CCR5	1234	broad.mit.edu	37	3	46414494	46414494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46414494C>T	ENST00000343801.4	+	3	458	c.101C>T	c.(100-102)cCt>cTt	p.P34L	CCR5_ENST00000445772.1_Missense_Mutation_p.P34L|CCR5_ENST00000292303.4_Missense_Mutation_p.P34L|RP11-24F11.2_ENST00000451485.1_RNA	NM_000579.3	NP_000570.1	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5 (gene/pseudogene)	34			P -> L (in TZCCR5-179).		cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			central_nervous_system(1)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	CGCCTCCTGCCTCCGCTCTAC	0.453000													48	144					0	0	1	0	0
CLRN2	645104	broad.mit.edu	37	4	17528621	17528621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:17528621G>A	ENST00000511148.2	+	3	717	c.615G>A	c.(613-615)gtG>gtA	p.V205V		NM_001079827.2	NP_001073296.1	A0PK11	CLRN2_HUMAN	clarin 2	205						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|upper_aerodigestive_tract(1)	15						ACTTGGTCGTGGTGGCGATCA	0.507000													30	80					0	0	1	0	0
ZNF512	84450	broad.mit.edu	37	2	27844028	27844028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27844028C>T	ENST00000355467.4	+	14	1487	c.1404C>T	c.(1402-1404)ttC>ttT	p.F468F	RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000413371.2_Silent_p.F391F|ZNF512_ENST00000556601.1_Silent_p.F337F|ZNF512_ENST00000379717.1_Silent_p.F467F|ZNF512_ENST00000416005.2_Silent_p.F439F			Q96ME7	ZN512_HUMAN	zinc finger protein 512	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F468F(2)		breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					AGGACTGGTTCGTTGTAAACC	0.418000													22	74					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52827674	52827674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52827674C>T	ENST00000252245.5	-	1	635	c.415G>A	c.(415-417)Gac>Aac	p.D139N		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	139	Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		ATGGTGGGGTCGATTTGCAGG	0.592000													49	102					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62675554	62675554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62675554G>A	ENST00000498273.1	+	4	1403	c.1108G>A	c.(1108-1110)Gag>Aag	p.E370K		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	370	Glu-rich.									breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						TAAGCCAGAGGAGATGAAAAA	0.438000													31	137					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883252	228883252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228883252G>A	ENST00000392056.3	-	7	2364	c.2318C>T	c.(2317-2319)cCa>cTa	p.P773L	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P773L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	773						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ATTGCTAAGTGGAGAGCTGCT	0.502000													53	130					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129833610	129833610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:129833610G>A	ENST00000421865.2	+	63	9009	c.8960G>A	c.(8959-8961)gGa>gAa	p.G2987E		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2987	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AAAATGGATGGAATGGGTATT	0.388000													58	106					0	0	1	0	0
SUSD5	26032	broad.mit.edu	37	3	33249379	33249379	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33249379G>A	ENST00000309558.3	-	3	747	c.330C>T	c.(328-330)atC>atT	p.I110I		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	110	Link.				cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CAGCTCTCATGATTTGCTGTT	0.418000													30	71					0	0	1	0	0
ART3	419	broad.mit.edu	37	4	77003470	77003470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77003470C>T	ENST00000355810.4	+	3	682	c.563C>T	c.(562-564)tCa>tTa	p.S188L	ART3_ENST00000349321.3_Missense_Mutation_p.S188L|ART3_ENST00000341029.5_Missense_Mutation_p.S188L|ART3_ENST00000513494.1_3'UTR	NM_001130016.2	NP_001123488.1	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3	188					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|stomach(1)	16			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTGGCATATTCAGCCAAACCT	0.423000													15	25					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64535070	64535070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64535070G>A	ENST00000377390.3	-	10	1652	c.1315C>T	c.(1315-1317)Cct>Tct	p.P439S	SF1_ENST00000377387.1_Missense_Mutation_p.P564S|SF1_ENST00000433274.2_Missense_Mutation_p.P413S|SF1_ENST00000422298.2_Missense_Mutation_p.P324S|SF1_ENST00000334944.5_Missense_Mutation_p.P439S|SF1_ENST00000227503.9_Missense_Mutation_p.P439S|SF1_ENST00000377394.3_Missense_Mutation_p.P439S	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	439	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						TGGTGCCCAGGAGGGTGGGGG	0.607000											OREG0021062	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	100					0	0	1	0	0
BHLHE22	27319	broad.mit.edu	37	8	65494180	65494180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:65494180G>A	ENST00000321870.1	+	1	1367	c.833G>A	c.(832-834)cGa>cAa	p.R278Q	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	278	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						CCCTCGGTGCGAAAGCTCTCC	0.647000													8	17					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360043	27360043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27360043G>A	ENST00000335524.3	-	3	1680	c.1155C>T	c.(1153-1155)gtC>gtT	p.V385V		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	385										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGGTAGTGACCTGTTTTG	0.582000													32	83					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64821816	64821816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64821816C>T	ENST00000358658.3	-	6	925	c.898G>A	c.(898-900)Gga>Aga	p.G300R	NAALADL1_ENST00000339885.2_Missense_Mutation_p.G300R|NAALADL1_ENST00000355721.3_Missense_Mutation_p.G259R|NAALADL1_ENST00000356632.3_Intron|NAALADL1_ENST00000355369.2_Missense_Mutation_p.G300R|NAALADL1_ENST00000340252.4_Missense_Mutation_p.G300R	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	300	NAALADase.				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						GCCAAAGTTCCGTTGAGGTTA	0.637000													15	40					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29848378	29848378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29848378G>A	ENST00000399218.4	-	6	2139	c.2084C>T	c.(2083-2085)cCc>cTc	p.P695L	GAREM_ENST00000269209.6_Missense_Mutation_p.P696L	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		GGCTGACTTGGGACAACCAGA	0.547000													42	80					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62687998	62687998	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:62687998C>T	ENST00000281156.4	-	4	734	c.456G>A	c.(454-456)ttG>ttA	p.L152L		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TAATCTCTTCCAATGCATGAC	0.373000													29	97					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117968808	117968808	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117968808C>T	ENST00000425217.1	-	12	1707	c.1653G>A	c.(1651-1653)ccG>ccA	p.P551P	KSR2_ENST00000302438.5_Silent_p.P277P|KSR2_ENST00000339824.5_Silent_p.P580P|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	580					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCTCCGGCACCGGCACCACAT	0.552000													48	119					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52568891	52568891	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52568891G>A	ENST00000389534.4	-	7	2703	c.2244C>T	c.(2242-2244)tcC>tcT	p.S748S	ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000359973.2_Intron|ZNF841_ENST00000594295.1_Silent_p.S748S|ZNF841_ENST00000426391.2_Silent_p.S632S	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	632				L -> P (in Ref. 1; BAC04190).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						GGGTTGTAGTGGAGTTAAAGA	0.428000													12	17					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47350726	47350726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47350726G>A	ENST00000400314.1	+	13	1161	c.823G>A	c.(823-825)Gaa>Aaa	p.E275K	PCBP3_ENST00000449640.1_Missense_Mutation_p.E275K|PRED62_ENST00000593412.1_Intron|PCBP3_ENST00000468429.1_3'UTR|PCBP3_ENST00000400308.1_Missense_Mutation_p.E249K|PCBP3_ENST00000400310.1_Intron|PCBP3_ENST00000400304.1_Missense_Mutation_p.E265K|PCBP3_ENST00000400309.1_Missense_Mutation_p.E274K			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	275					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		acactcctccgaagaagctca	0.522000													14	42					0	0	1	0	0
CASD1	64921	broad.mit.edu	37	7	94185045	94185045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94185045C>T	ENST00000297273.4	+	18	2656	c.2369C>T	c.(2368-2370)tCc>tTc	p.S790F		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	790						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			ATCTTATCATCCATTCAAGAT	0.338000													34	81					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76395539	76395539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76395539C>T	ENST00000357063.3	+	15	3850	c.2590C>T	c.(2590-2592)Cct>Tct	p.P864S	LMO7_ENST00000377534.3_Missense_Mutation_p.P864S|LMO7_ENST00000321797.8_Missense_Mutation_p.P579S|LMO7_ENST00000526202.1_Missense_Mutation_p.P429S|LMO7_ENST00000341547.4_Missense_Mutation_p.P530S|LMO7_ENST00000465261.2_Missense_Mutation_p.P579S			Q8WWI1	LMO7_HUMAN	LIM domain 7	864						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AATTCAGCTTCCTTCTCAAAG	0.443000													8	128					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164584	139164584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139164584C>T	ENST00000395297.1	-	13	2304	c.2134G>A	c.(2134-2136)Gaa>Aaa	p.E712K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	712										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGCAAGACTTCCCGATCACTG	0.552000										HNSCC(54;0.14)			9	27					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47300925	47300925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:47300925G>A	ENST00000319190.5	+	20	2808	c.2440G>A	c.(2440-2442)Gag>Aag	p.E814K	TTC7A_ENST00000394850.2_Missense_Mutation_p.E838K|CALM2_ENST00000422269.1_Intron|TTC7A_ENST00000409245.1_Missense_Mutation_p.E780K|TTC7A_ENST00000263737.6_Missense_Mutation_p.E460K	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	814							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TACGTGCCACGAGGCGTGGCA	0.662000													30	50					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110835662	110835662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110835662C>T	ENST00000296632.3	-	6	674	c.540G>A	c.(538-540)atG>atA	p.M180I	STARD4_ENST00000512160.1_3'UTR	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	180	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		ACTGAGGAATCATCCCACGCA	0.413000													50	97					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226564933	226564933	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226564933G>A	ENST00000366794.5	-	13	1960	c.1817C>T	c.(1816-1818)tCc>tTc	p.S606F		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	606					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		ATCCTCCTTGGACGGCATCTG	0.473000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					112	313					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43625192	43625192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43625192G>A	ENST00000405006.4	-	29	4496	c.4145C>T	c.(4144-4146)aCc>aTc	p.T1382I	THADA_ENST00000330266.7_Intron|THADA_ENST00000485353.1_5'UTR|THADA_ENST00000415080.2_Missense_Mutation_p.T1063I|THADA_ENST00000405975.2_Missense_Mutation_p.T1382I	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1382							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AGTTCGAATGGTATTAGGAAT	0.483000													37	84					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897566	153897566	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:153897566C>T	ENST00000511601.1	+	12	3311	c.3123C>T	c.(3121-3123)gcC>gcT	p.A1041A	FHDC1_ENST00000260008.3_Silent_p.A1041A			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1041					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					ACACAGTGGCCTCCTCCTCTC	0.637000													35	93					0	0	1	0	0
CORO6	84940	broad.mit.edu	37	17	27943157	27943157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:27943157G>A	ENST00000345068.5	-	10	1312	c.1099C>T	c.(1099-1101)Cca>Tca	p.P367S	CORO6_ENST00000445145.2_Missense_Mutation_p.P367S|CORO6_ENST00000577909.1_5'UTR|CORO6_ENST00000584969.1_Missense_Mutation_p.P367S|CORO6_ENST00000580212.1_Missense_Mutation_p.P327S|CORO6_ENST00000388767.3_Missense_Mutation_p.P367S|CORO6_ENST00000456796.3_Missense_Mutation_p.P133S|RP11-68I3.2_ENST00000581474.1_RNA			Q6QEF8	CORO6_HUMAN	coronin 6	367					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						TCCGGGCCTGGCGTATCCGGG	0.662000													18	14					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52023386	52023386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52023386C>T	ENST00000346477.3	-	7	1332	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	SIGLEC6_ENST00000391797.3_3'UTR|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.E386K|SIGLEC6_ENST00000474054.1_5'UTR|CTD-3073N11.9_ENST00000598220.1_RNA|SIGLEC6_ENST00000359982.4_3'UTR|SIGLEC6_ENST00000343300.4_3'UTR|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.E438K	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	438					cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		ACCTTTGGTTCCTGAGGTTGC	0.498000													59	146					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54894350	54894350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54894350G>A	ENST00000293373.6	+	3	326	c.247G>A	c.(247-249)Gag>Aag	p.E83K	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E33K	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	83					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity	p.E83K(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TGAAAAAGCCGAGATAATTAG	0.383000													46	174					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15349239	15349239	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15349239G>C	ENST00000263377.2	-	20	4259	c.4038C>G	c.(4036-4038)gaC>gaG	p.D1346E		NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	1346					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GGAAATTCATGTCAATGGTAG	0.468000			T	C15orf55	lethal midline carcinoma of young people								24	88					0	0	1	0	0
TMEM205	374882	broad.mit.edu	37	19	11456054	11456054	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11456054G>A	ENST00000354882.5	-	2	564	c.138C>T	c.(136-138)ttC>ttT	p.F46F	TMEM205_ENST00000589555.1_Silent_p.F46F|CCDC159_ENST00000588790.1_5'UTR|TMEM205_ENST00000447337.1_Silent_p.F46F|RAB3D_ENST00000589655.1_Intron|TMEM205_ENST00000593256.2_Silent_p.F46F|TMEM205_ENST00000588560.1_Silent_p.F46F|TMEM205_ENST00000587948.1_Silent_p.F46F|TMEM205_ENST00000586218.1_5'UTR|TMEM205_ENST00000586590.1_Silent_p.F46F|CCDC159_ENST00000587100.1_3'UTR|TMEM205_ENST00000586956.1_Silent_p.F46F			Q6UW68	TM205_HUMAN	transmembrane protein 205	46						integral to membrane				endometrium(1)|lung(1)	2						GCACTAGTCCGAAGGTATGTC	0.552000													10	58					0	0	1	0	0
DEFB112	245915	broad.mit.edu	37	6	50016297	50016297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:50016297G>A	ENST00000322246.4	-	1	67	c.68C>T	c.(67-69)tCc>tTc	p.S23F		NM_001037498.1	NP_001032587.1	Q30KQ8	DB112_HUMAN	defensin, beta 112	23					defense response to bacterium	extracellular region				central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.042)					AAATATTGTGGAAGATGTATT	0.333000													13	60					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51749298	51749298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51749298C>T	ENST00000395052.3	+	4	1743	c.1509C>T	c.(1507-1509)ccC>ccT	p.P503P	GRM2_ENST00000442933.2_Intron|GRM2_ENST00000475478.1_3'UTR	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	503					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCAGTGAGCCCTGCCTCCAGA	0.622000													14	25					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143513864	143513864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:143513864G>A	ENST00000316549.6	-	4	720	c.512C>T	c.(511-513)gCc>gTc	p.A171V		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	171					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						GCAGGAGATGGCAGTTCCCAA	0.413000													35	77					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155148391	155148391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155148391G>A	ENST00000392451.2	+	3	436	c.353G>A	c.(352-354)cGa>cAa	p.R118Q	TRIM46_ENST00000545012.1_5'UTR|TRIM46_ENST00000543729.1_Missense_Mutation_p.R125Q|TRIM46_ENST00000368383.3_Missense_Mutation_p.R118Q|TRIM46_ENST00000334634.4_Missense_Mutation_p.R118Q|TRIM46_ENST00000368382.1_Missense_Mutation_p.R95Q|TRIM46_ENST00000368385.4_Missense_Mutation_p.R118Q|TRIM46_ENST00000468878.1_3'UTR			Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	118						intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGGAGGAAGCGAGGTGCTTTG	0.582000													90	192					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538757	55538757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55538757G>A	ENST00000220676.1	+	4	2463	c.2315G>A	c.(2314-2316)gGa>gAa	p.G772E		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	772					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGTTCAAGGACTTTTAACC	0.294000													6	46					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407199	38407199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38407199C>T	ENST00000322350.5	+	8	1444	c.1098C>T	c.(1096-1098)ggC>ggT	p.G366G	EGFLAM_ENST00000336740.6_Silent_p.G132G|EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000354891.3_Silent_p.G366G	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	366	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					CCTGGGGGGGCTCGCGATGCC	0.537000													22	50					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19184088	19184088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19184088C>T	ENST00000355377.2	+	2	420	c.22C>T	c.(22-24)Cca>Tca	p.P8S	SYT17_ENST00000562034.1_5'UTR|SYT17_ENST00000568115.1_Intron|SYT17_ENST00000562711.2_Missense_Mutation_p.P4S|CTD-2349B8.1_ENST00000564808.2_3'UTR	NM_016524.2	NP_057608.2	Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	8						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						GCAGTTGGAACCATTAAACGA	0.433000													14	59					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98744710	98744710	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98744710C>T	ENST00000477737.1	+	6	915	c.711C>T	c.(709-711)tcC>tcT	p.S237S	VWA3B_ENST00000451075.2_Silent_p.S87S|VWA3B_ENST00000435344.1_Silent_p.S237S	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	237										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AGATTGAATCCATTTACTACT	0.478000													45	125					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94204131	94204131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94204131C>T	ENST00000515393.1	-	17	2342	c.2343G>A	c.(2341-2343)atG>atA	p.M781I	MCTP1_ENST00000505208.1_Missense_Mutation_p.M560I|MCTP1_ENST00000429576.2_Missense_Mutation_p.M514I|MCTP1_ENST00000505078.1_Missense_Mutation_p.M297I|MCTP1_ENST00000312216.8_Missense_Mutation_p.M560I	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	781					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		CACAACGTTTCATTCTGATAA	0.358000													8	30					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624786	123624786	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123624786C>T	ENST00000327930.2	-	1	467	c.441G>A	c.(439-441)tgG>tgA	p.W147*		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGCCCACCACCCAGGAGCTCA	0.512000													21	83					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43708284	43708284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43708284G>A	ENST00000405312.3	-	2	421	c.184C>T	c.(184-186)Ctt>Ttt	p.L62F	PSG4_ENST00000433626.2_Missense_Mutation_p.L62F|PSG4_ENST00000244295.9_Missense_Mutation_p.L62F	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	62	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				TAGCCAGCAAGATTCTGGGGC	0.448000													29	364					0	0	1	0	0
FOXJ2	55810	broad.mit.edu	37	12	8196618	8196618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8196618C>T	ENST00000162391.3	+	5	1694	c.549C>T	c.(547-549)gcC>gcT	p.A183A	FOXJ2_ENST00000428177.2_Silent_p.A183A	NM_018416.2	NP_060886.1	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	183					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		GTGGAGAAGCCTCACTGCCTC	0.547000													31	88					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76565478	76565478	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76565478C>T	ENST00000389840.5	-	8	1300	c.1176G>A	c.(1174-1176)gtG>gtA	p.V392V	DNAH17_ENST00000585328.1_Silent_p.V392V					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCTTCATGTTCACGCAGCAGA	0.522000													7	12					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136481641	136481641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136481641C>T	ENST00000264160.4	+	26	3449	c.3079C>T	c.(3079-3081)Cgt>Tgt	p.R1027C	R3HDM1_ENST00000329971.3_Missense_Mutation_p.R898C|R3HDM1_ENST00000410054.1_Missense_Mutation_p.R972C|R3HDM1_ENST00000409478.1_Missense_Mutation_p.R899C|R3HDM1_ENST00000409606.1_Missense_Mutation_p.R1028C	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	1027							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		CCAACCACGTCGTCACCCCCT	0.557000													32	85					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826247	43826247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43826247C>T	ENST00000389420.3	-	21	2955	c.2956G>A	c.(2956-2958)Gaa>Aaa	p.E986K	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.E140K|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E986K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	986	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CGAGACCTTTCCCCTCCTCCA	0.368000													17	83					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121785550	121785550	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121785550G>A	ENST00000261367.7	+	11	3172	c.1744G>A	c.(1744-1746)Gaa>Aaa	p.E582K	SNCAIP_ENST00000261368.8_Missense_Mutation_p.E535K|SNCAIP_ENST00000414317.2_Missense_Mutation_p.E137K|SNCAIP_ENST00000542191.1_Missense_Mutation_p.E93K|SNCAIP_ENST00000379538.3_Missense_Mutation_p.E169K|CTC-210G5.1_ENST00000505546.1_RNA|CTC-210G5.1_ENST00000510972.1_RNA|CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E475K|SNCAIP_ENST00000503116.2_3'UTR|SNCAIP_ENST00000504884.2_3'UTR|CTC-210G5.1_ENST00000503529.1_RNA|CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E582K			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	535					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACAAACAGTAGAACGTGTCAC	0.413000													44	148					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285576	48285576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48285576C>T	ENST00000320048.1	+	1	164	c.164C>T	c.(163-165)tCc>tTc	p.S55F		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S55F(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GTGCTCACCTCCCCCATGTAT	0.478000													23	36					0	0	1	0	0
PPM1K	152926	broad.mit.edu	37	4	89199393	89199393	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89199393G>A	ENST00000295908.6	-	2	732	c.343C>T	c.(343-345)Cag>Tag	p.Q115*	PPM1K_ENST00000315194.4_Nonsense_Mutation_p.Q115*|PPM1K_ENST00000513546.2_5'UTR|PPM1K_ENST00000506423.1_Nonsense_Mutation_p.Q115*	NM_152542.3	NP_689755.3	Q8N3J5	PPM1K_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1K	115	PP2C-like.				protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	13		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		TCTGTCAGCTGAGCGAAGTCA	0.463000													17	19					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43501528	43501528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43501528C>T	ENST00000300215.3	-	6	1323	c.866G>A	c.(865-867)cGa>cAa	p.R289Q	EPB42_ENST00000441366.2_Missense_Mutation_p.R259Q|EPB42_ENST00000540029.1_Missense_Mutation_p.R181Q			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	259					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		AGGTCGGCCTCGGCCGGTGAG	0.672000													6	57					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	51948359	51948359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:51948359G>A	ENST00000311234.4	-	15	2561	c.2089C>T	c.(2089-2091)Ctt>Ttt	p.L697F	INTS6_ENST00000463928.1_3'UTR|INTS6_ENST00000497989.1_Missense_Mutation_p.L519F|INTS6_ENST00000398119.2_Missense_Mutation_p.L684F|INTS6_ENST00000425000.1_Missense_Mutation_p.L265F|INTS6_ENST00000490542.1_Missense_Mutation_p.L381F	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	697					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		TGAAGAGGAAGAGGTTTAATA	0.358000													51	136					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11384820	11384820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:11384820C>T	ENST00000304623.8	-	7	1323	c.1134G>A	c.(1132-1134)gaG>gaA	p.E378E	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Intron|CTNND2_ENST00000511377.1_Silent_p.E287E|CTNND2_ENST00000458100.2_Intron|CTNND2_ENST00000359640.2_Silent_p.E378E	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	378					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGGCATACAGCTCCTGCGAGT	0.692000													7	12					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331897	70331897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70331897C>T	ENST00000338508.4	-	32	4503	c.4504G>A	c.(4504-4506)Gac>Aac	p.D1502N	SHANK2_ENST00000423696.2_Missense_Mutation_p.D1122N|SHANK2_ENST00000409161.1_Missense_Mutation_p.D905N|SHANK2_ENST00000449833.2_Missense_Mutation_p.D906N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1122					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AGGTGGTGGTCGCTGCTACTC	0.582000													37	24					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46086047	46086047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46086047C>T	ENST00000295452.4	-	3	444	c.277G>A	c.(277-279)Gat>Aat	p.D93N		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	93					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		ACATAAACATCAGTTTCAATT	0.299000													9	13					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154516910	154516910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154516910C>T	ENST00000368482.4	+	10	1552	c.714C>T	c.(712-714)ccC>ccT	p.P238P	TDRD10_ENST00000479937.1_3'UTR|TDRD10_ENST00000368480.3_Silent_p.P238P	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	238	Tudor.						nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCAGCAGCCCTACCTGGAGG	0.637000													4	11					0	0	1	0	0
NGRN	51335	broad.mit.edu	37	15	90814604	90814604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90814604C>T	ENST00000379095.3	+	3	468	c.460C>T	c.(460-462)Cgg>Tgg	p.R154W	NGRN_ENST00000331497.3_3'UTR|RP11-697E2.6_ENST00000561573.1_3'UTR	NM_001033088.1	NP_001028260.2	Q9NPE2	NGRN_HUMAN	neugrin, neurite outgrowth associated	154					neuron differentiation	extracellular region|nucleus				kidney(2)|large_intestine(4)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GCAGCACCTCCGGGGCTCTGG	0.493000													20	94					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	119996563	119996563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119996563G>A	ENST00000341846.5	-	4	1590	c.1169C>T	c.(1168-1170)cCc>cTc	p.P390L	TRIM29_ENST00000529044.1_Missense_Mutation_p.P129L|TRIM29_ENST00000541857.1_Missense_Mutation_p.P123L	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	390					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CAGGGGTGGGGGGAGAGAGTA	0.537000													25	63					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41559131	41559131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41559131C>T	ENST00000396942.1	-	22	2481	c.2398G>A	c.(2398-2400)Gat>Aat	p.D800N	ANK1_ENST00000289734.7_Missense_Mutation_p.D800N|ANK1_ENST00000347528.4_Missense_Mutation_p.D800N|ANK1_ENST00000379758.2_Missense_Mutation_p.D800N|ANK1_ENST00000352337.4_Missense_Mutation_p.D800N|ANK1_ENST00000265709.8_Missense_Mutation_p.D833N|ANK1_ENST00000396945.1_Missense_Mutation_p.D800N			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	800	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CGATGCTTATCACTGACTAAC	0.483000											OREG0018740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	63					0	0	1	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142542441	142542441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142542441C>T	ENST00000295992.3	-	7	1188	c.882G>A	c.(880-882)gtG>gtA	p.V294V	PCOLCE2_ENST00000485766.1_Intron	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	294						extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						GACACAAGGCCACGGTGGGTT	0.358000													32	73					0	0	1	0	0
IFLTD1	160492	broad.mit.edu	37	12	25679772	25679772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25679772C>T	ENST00000539744.1	-	5	734	c.255G>A	c.(253-255)gtG>gtA	p.V85V	IFLTD1_ENST00000445693.1_Silent_p.V119V|IFLTD1_ENST00000458174.2_Silent_p.V203V|IFLTD1_ENST00000413632.2_Silent_p.V203V|IFLTD1_ENST00000282881.6_Silent_p.V182V	NM_001256266.1	NP_001243195.1	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	182						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TTTGTCCATTCACATTTTGCT	0.368000													30	59					0	0	1	0	0
HAS1	3036	broad.mit.edu	37	19	52220436	52220436	+	Missense_Mutation	SNP	G	G	A	rs143266369	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52220436G>A	ENST00000540069.2	-	3	770	c.710C>T	c.(709-711)tCg>tTg	p.S237L	HAS1_ENST00000594621.1_Missense_Mutation_p.S92L|HAS1_ENST00000601714.1_Missense_Mutation_p.S245L|HAS1_ENST00000222115.1_Missense_Mutation_p.S238L			Q92839	HAS1_HUMAN	hyaluronan synthase 1	238					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CCTTGTGTCCGAGTCACAGAC	0.617000													20	46					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99439496	99439496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99439496G>A	ENST00000397899.2	-	7	1571	c.1240C>T	c.(1240-1242)Ccc>Tcc	p.P414S		NM_207362.2	NP_997245.2			KIAA1211-like																		TCAGTCTCGGGGGGAGTCGTG	0.721000													6	14					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110882049	110882049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110882049C>T	ENST00000265171.5	+	7	1538	c.1093C>T	c.(1093-1095)Cat>Tat	p.H365Y	EGF_ENST00000509793.1_Missense_Mutation_p.H323Y|EGF_ENST00000503392.1_Missense_Mutation_p.H365Y	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	365	EGF-like 2; calcium-binding (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TTTTTGGAATCATGGCTGTAC	0.388000													16	69					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1755118	1755118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1755118G>A	ENST00000397196.2	+	5	1012	c.780G>A	c.(778-780)aaG>aaA	p.K260K	WNT5B_ENST00000310594.3_Silent_p.K260K|WNT5B_ENST00000545747.1_3'UTR|WNT5B_ENST00000537031.1_Silent_p.K260K	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	260					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			TCACCCGCAAGGGCCGGCTGG	0.682000													17	32					0	0	1	0	0
CPT1A	1374	broad.mit.edu	37	11	68571514	68571514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68571514G>A	ENST00000265641.5	-	5	663	c.509C>T	c.(508-510)tCg>tTg	p.S170L	CPT1A_ENST00000539743.1_Missense_Mutation_p.S170L|CPT1A_ENST00000540367.1_Missense_Mutation_p.S170L|CPT1A_ENST00000376618.2_Missense_Mutation_p.S170L	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	170					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GCGAGGCAGCGATGTCTGGAA	0.498000													25	56					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81719638	81719638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81719638C>T	ENST00000550584.2	-	21	2855	c.2560G>A	c.(2560-2562)Gag>Aag	p.E854K	PPFIA2_ENST00000549396.1_Missense_Mutation_p.E854K|PPFIA2_ENST00000541570.2_Missense_Mutation_p.E421K|PPFIA2_ENST00000548586.1_Missense_Mutation_p.E854K|PPFIA2_ENST00000552948.1_Missense_Mutation_p.E854K|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Missense_Mutation_p.E836K|PPFIA2_ENST00000550359.2_Missense_Mutation_p.E701K|PPFIA2_ENST00000407050.4_Missense_Mutation_p.E780K|PPFIA2_ENST00000333447.7_Missense_Mutation_p.E836K|PPFIA2_ENST00000443686.3_Missense_Mutation_p.E755K|PPFIA2_ENST00000541017.1_Missense_Mutation_p.E71K	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	780										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GCTTCAGTCTCCATAAAGCCT	0.423000													9	36					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620296	7620296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:7620296G>A	ENST00000486284.1	+	8	1977	c.1703G>A	c.(1702-1704)aGg>aAg	p.R568K	GRM7_ENST00000403881.1_Missense_Mutation_p.R568K|GRM7_ENST00000389336.4_Missense_Mutation_p.R568K|GRM7_ENST00000402647.2_Missense_Mutation_p.R568K|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000357716.4_Missense_Mutation_p.R568K	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	568					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TATGACCAGAGGCCCAATGAA	0.522000													53	97					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179732796	179732796	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179732796G>A	ENST00000420890.2	-	16	2648	c.2531C>T	c.(2530-2532)gCc>gTc	p.A844V	CCDC141_ENST00000295723.5_Missense_Mutation_p.A269V	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	269	Ig-like.						protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TAAGGAAAGGGCCAGTCTGTG	0.522000													16	72					0	0	1	0	0
KLRD1	3824	broad.mit.edu	37	12	10464155	10464155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10464155C>T	ENST00000381908.3	+	4	516	c.256C>T	c.(256-258)Cgg>Tgg	p.R86W	KLRD1_ENST00000538997.1_3'UTR|KLRD1_ENST00000381907.4_Missense_Mutation_p.R86W|KLRD1_ENST00000350274.5_Missense_Mutation_p.R55W|KLRD1_ENST00000336164.4_Missense_Mutation_p.R86W|KLRD1_ENST00000543777.1_Missense_Mutation_p.R65W|KLRD1_ENST00000543420.1_Missense_Mutation_p.R86W			Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D, member 1	86	C-type lectin.				cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	10						GAACGAAAGTCGGCATCTCTG	0.438000													19	82					0	0	1	0	0
CA6	765	broad.mit.edu	37	1	9027799	9027799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9027799C>T	ENST00000377443.2	+	6	657	c.653C>T	c.(652-654)tCa>tTa	p.S218L	CA6_ENST00000377442.2_Missense_Mutation_p.S158L|CA6_ENST00000476083.1_3'UTR|CA6_ENST00000377436.3_Missense_Mutation_p.S218L	NM_001215.3	NP_001206.2	P23280	CAH6_HUMAN	carbonic anhydrase VI	218					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		TACCATGGCTCACTCACCACG	0.527000													32	70					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48124510	48124510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:48124510C>T	ENST00000244043.4	-	10	1479	c.1450G>A	c.(1450-1452)Ggt>Agt	p.G484S	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	484					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TGCATCAGACCGAAGCCGTAC	0.597000													13	38					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640665	34640665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34640665C>T	ENST00000537011.1	+	3	978	c.596C>T	c.(595-597)cCc>cTc	p.P199L	NUTM1_ENST00000333756.4_Missense_Mutation_p.P171L|NUTM1_ENST00000438749.3_Missense_Mutation_p.P189L					NUT midline carcinoma, family member 1																		CAACTGGTCCCCATTGTGCCC	0.602000													14	30					0	0	1	0	0
ZNF20	7568	broad.mit.edu	37	19	12243696	12243696	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12243696G>A	ENST00000334213.5	-	4	1529	c.1305C>T	c.(1303-1305)ttC>ttT	p.F435F	ZNF20_ENST00000600335.1_Intron|ZNF625-ZNF20_ENST00000430024.1_3'UTR	NM_001203250.1|NM_021143.3	NP_001190179.1|NP_066966.2	P17024	ZNF20_HUMAN	zinc finger protein 20	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|lung(6)	8						GCAAGGAAGAGAAATACCTGA	0.408000													21	68					0	0	1	0	0
FAM135A	57579	broad.mit.edu	37	6	71269569	71269569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:71269569C>T	ENST00000418814.2	+	22	5107	c.4493C>T	c.(4492-4494)tCg>tTg	p.S1498L	FAM135A_ENST00000505769.1_Missense_Mutation_p.S1078L|FAM135A_ENST00000361499.3_Missense_Mutation_p.S1302L|FAM135A_ENST00000370479.3_Missense_Mutation_p.S1285L|FAM135A_ENST00000457062.2_Missense_Mutation_p.S1285L	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	1498										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						GTTCTTGATTCGGAAATATTT	0.373000													20	22					0	0	1	0	0
WFDC8	90199	broad.mit.edu	37	20	44184463	44184463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44184463C>T	ENST00000357199.4	-	4	400	c.322G>A	c.(322-324)Gca>Aca	p.A108T	WFDC8_ENST00000289953.2_Missense_Mutation_p.A108T	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	108	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				CAGCGCTGTGCCTCATGATTA	0.463000													26	76					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2705137	2705137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2705137G>A	ENST00000399655.1	+	20	3026	c.2761G>A	c.(2761-2763)Gac>Aac	p.D921N	CACNA1C_ENST00000347598.4_Missense_Mutation_p.D921N|CACNA1C_ENST00000399591.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000480911.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000344100.3_Missense_Mutation_p.D921N|CACNA1C_ENST00000399597.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000335762.5_Missense_Mutation_p.D946N|CACNA1C_ENST00000399595.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399603.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399617.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399606.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399621.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399601.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399638.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399649.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399644.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399629.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000327702.7_Missense_Mutation_p.D921N|CACNA1C_ENST00000399634.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399637.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000406454.3_Missense_Mutation_p.D921N|CACNA1C_ENST00000402845.3_Missense_Mutation_p.D921N|CACNA1C_ENST00000399641.1_Missense_Mutation_p.D921N	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	921					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGCTGCTGAGGACCCGGTCCA	0.572000													21	70					0	0	1	0	0
LCN9	392399	broad.mit.edu	37	9	138556088	138556088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138556088C>T	ENST00000277526.3	+	2	177	c.177C>T	c.(175-177)ttC>ttT	p.F59F	LCN9_ENST00000430290.2_3'UTR	NM_001001676.1	NP_001001676.1	Q8WX39	LCN9_HUMAN	lipocalin 9	59						extracellular region	pheromone binding|transporter activity			kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	6		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		TGAGGGTCTTCGTCCGGAATA	0.468000													18	75					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72975151	72975151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:72975151C>T	ENST00000521978.1	+	21	3253	c.3253C>T	c.(3253-3255)Cat>Tat	p.H1085Y	RIMS1_ENST00000401910.3_Intron|RIMS1_ENST00000538414.1_Intron|RIMS1_ENST00000348717.5_Intron|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000264839.7_Intron|RIMS1_ENST00000517960.1_Intron|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000518273.1_Intron|RIMS1_ENST00000491071.2_Intron|RIMS1_ENST00000425662.2_Intron	NM_014989.5	NP_055804.2	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1085					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.H1085N(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CATTTCCCTTCATCATGAATG	0.323000													5	46					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039053	11039053	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039053C>T	ENST00000470054.1	-	0	1150									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGAGTCCATCAATCCAGTAG	0.383000													35	740					0	0	1	0	0
RAB9BP1	9366	broad.mit.edu	37	5	104435182	104435182	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:104435182G>A	ENST00000522464.1	-	0	68				RP11-6N13.1_ENST00000503650.1_lincRNA																							TTAACGGCAGGAAAATCATCA	0.358000													10	35					0	0	1	0	0
PGC	5225	broad.mit.edu	37	6	41704679	41704679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41704679G>A	ENST00000373025.3	-	9	1140	c.1078C>T	c.(1078-1080)Ctg>Ttg	p.L360L		NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	360					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			AGGATCCACAGGGGCTGGCCG	0.562000													20	57					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10755639	10755639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10755639G>A	ENST00000416569.2	-	3	1775	c.1749C>T	c.(1747-1749)ccC>ccT	p.P583P	XKR6_ENST00000304437.2_Silent_p.P304P	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	583						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		TCTTAATGAGGGGCCCTTCTG	0.512000													13	39					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53839141	53839141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53839141C>T	ENST00000288139.3	+	46	5895	c.5777C>T	c.(5776-5778)cCa>cTa	p.P1926L	CACNA1D_ENST00000422281.2_Missense_Mutation_p.P1882L|CACNA1D_ENST00000544977.1_Missense_Mutation_p.P285L|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P1906L	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1906					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CGGAGATCTCCAAGGAGACGC	0.572000													46	84					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35806986	35806986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35806986G>A	ENST00000440995.2	+	35	5173	c.5173G>A	c.(5173-5175)Ggg>Agg	p.G1725R	SPEF2_ENST00000356031.3_Missense_Mutation_p.G1730R|SPEF2_ENST00000303129.4_Missense_Mutation_p.G527R|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1730					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTGTTCAAAGGGGGAAGTGA	0.393000													26	58					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43547321	43547321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43547321G>A	ENST00000400427.1	+	18	4063	c.3667G>A	c.(3667-3669)Gac>Aac	p.D1223N	UMODL1_ENST00000400423.2_3'UTR|UMODL1_ENST00000408989.2_Missense_Mutation_p.D1295N|UMODL1_ENST00000400424.1_Missense_Mutation_p.D1095N|UMODL1_ENST00000408910.2_Missense_Mutation_p.D1167N	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	1167	ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CAACGCCCGGGACCCCATCAC	0.567000													16	65					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142231686	142231686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142231686G>A	ENST00000519067.1	-	2	570	c.267C>T	c.(265-267)ggC>ggT	p.G89G	SLC45A4_ENST00000024061.3_Silent_p.G89G|SLC45A4_ENST00000433583.2_Silent_p.G82G|SLC45A4_ENST00000517878.1_Silent_p.G140G			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	140					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CGATGGCAGAGCCGTTAAGGA	0.607000													20	65					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87082389	87082389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87082389G>A	ENST00000265723.4	-	6	518	c.407C>T	c.(406-408)tCa>tTa	p.S136L	ABCB4_ENST00000359206.3_Missense_Mutation_p.S136L|ABCB4_ENST00000545634.1_Missense_Mutation_p.S136L|ABCB4_ENST00000358400.3_Missense_Mutation_p.S136L|ABCB4_ENST00000453593.1_Missense_Mutation_p.S136L	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	136	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGTCCAAAATGAAACTTGTAT	0.388000													35	90					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71200008	71200008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:71200008G>A	ENST00000554752.2	-	11	2077	c.2078C>T	c.(2077-2079)tCa>tTa	p.S693L	MAP3K9_ENST00000555993.2_Missense_Mutation_p.S707L|MAP3K9_ENST00000553414.1_Missense_Mutation_p.S426L|MAP3K9_ENST00000381250.4_Missense_Mutation_p.S670L|MAP3K9_ENST00000554146.1_Missense_Mutation_p.S421L			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	693					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		ctggctgggtgaatgctgtag	0.552000													10	24					0	0	1	0	0
C14orf159	80017	broad.mit.edu	37	14	91647573	91647573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91647573G>A	ENST00000518868.1	+	11	1464	c.774G>A	c.(772-774)atG>atA	p.M258I	C14orf159_ENST00000412671.2_Missense_Mutation_p.M258I|C14orf159_ENST00000520328.1_Missense_Mutation_p.M241I|C14orf159_ENST00000525393.2_Missense_Mutation_p.M129I|C14orf159_ENST00000523816.1_Missense_Mutation_p.M253I|C14orf159_ENST00000523771.1_Missense_Mutation_p.M253I|C14orf159_ENST00000521077.2_Missense_Mutation_p.M258I|C14orf159_ENST00000428926.2_Missense_Mutation_p.M253I|C14orf159_ENST00000256324.10_Missense_Mutation_p.M258I|C14orf159_ENST00000522322.1_Missense_Mutation_p.M253I			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	253						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		GCACAGTTATGACTGACCTGA	0.542000													20	35					0	0	1	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206950	142206950	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142206950C>T	ENST00000426318.2	-	0	61																											GAAGAAGAGCCTGGTGCCCAT	0.552000													13	39					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683514	159683514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159683514G>A	ENST00000255030.5	-	2	579	c.476C>T	c.(475-477)tCc>tTc	p.S159F	CRP_ENST00000368110.1_Intron|CRP_ENST00000473196.1_5'UTR|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000437342.1_5'UTR|CRP_ENST00000368111.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	159	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	CCCACCGAAGGAATCCTGCTC	0.522000													125	339					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	130984529	130984529	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130984529G>A	ENST00000341179.7	+	7	995	c.903G>A	c.(901-903)caG>caA	p.Q301Q	DNM1_ENST00000393594.3_Silent_p.Q301Q|DNM1_ENST00000475805.1_Silent_p.Q301Q|DNM1_ENST00000372923.3_Silent_p.Q301Q|DNM1_ENST00000486160.1_Silent_p.Q301Q	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	301					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						ACAAGCTGCAGAGCCAGCTAC	0.597000													26	90					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149460541	149460541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149460541C>T	ENST00000286301.3	-	3	387	c.96G>A	c.(94-96)gtG>gtA	p.V32V	CSF1R_ENST00000543093.1_Silent_p.V32V	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	32	Ig-like C2-type 1.		V -> G (in dbSNP:rs56048668).		cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CTCCTGGCTTCACGACCAGCT	0.602000													10	13					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7576563	7576563	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7576563G>A	ENST00000379802.3	+	19	3008	c.2667G>A	c.(2665-2667)agG>agA	p.R889R	DSP_ENST00000418664.2_Silent_p.R889R	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	889	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGCAATTGAGGAATTATCGTG	0.373000													32	71					0	0	1	0	0
VILL	50853	broad.mit.edu	37	3	38045833	38045833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38045833C>T	ENST00000283713.6	+	16	2159	c.1893C>T	c.(1891-1893)ttC>ttT	p.F631F	VILL_ENST00000383759.2_Silent_p.F631F|VILL_ENST00000465644.1_Silent_p.F349F			O15195	VILL_HUMAN	villin-like	631					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AAGTGGGGTTCTTCAGCCAGG	0.622000											OREG0015475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	44					0	0	1	0	0
OR5M11	219487	broad.mit.edu	37	11	56310108	56310108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56310108G>A	ENST00000528616.2	-	1	649	c.626C>T	c.(625-627)tCc>tTc	p.S209F		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						GATGGTGAGGGAGCTGGAGAG	0.502000													6	59					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51054558	51054558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51054558C>T	ENST00000441560.2	+	3	525	c.44C>T	c.(43-45)tCg>tTg	p.S15L	ATL1_ENST00000358385.6_Missense_Mutation_p.S15L|ATL1_ENST00000556478.2_3'UTR|ATL1_ENST00000354525.4_Missense_Mutation_p.S15L|ATL1_ENST00000357032.3_Missense_Mutation_p.S15L	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	15					axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						GGTGGATTTTCGGAAAAGACA	0.433000													26	61					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15410457	15410457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:15410457C>T	ENST00000341776.2	+	3	428	c.184C>T	c.(184-186)Ctc>Ttc	p.L62F	JARID2_ENST00000541660.1_Missense_Mutation_p.L24F|JARID2_ENST00000397311.3_5'UTR	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	62					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				ACCTGTAGGGCTCCTTGGTAA	0.463000													33	82					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34554765	34554765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34554765G>A	ENST00000373381.4	-	2	393	c.217C>T	c.(217-219)Ccc>Tcc	p.P73S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	33	CUB 1.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTCCCATTGGGACCGTGCAGT	0.532000													14	31					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120474838	120474838	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:120474838C>T	ENST00000355622.6	+	3	533	c.432C>T	c.(430-432)ttC>ttT	p.F144F	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.F104F	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	144					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TAGAGAACTTCCCCATTGGAC	0.408000													30	74					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55381392	55381392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55381392G>A	ENST00000398661.2	-	5	528	c.397C>T	c.(397-399)Cac>Tac	p.H133Y	HMGCLL1_ENST00000308161.4_Intron|HMGCLL1_ENST00000508459.1_Intron|HMGCLL1_ENST00000274901.4_Missense_Mutation_p.H103Y|HMGCLL1_ENST00000428842.1_Intron|HMGCLL1_ENST00000370850.2_Intron	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	133							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACTTCAGTGTGATCAGCCATC	0.363000													22	83					0	0	1	0	0
MRAP	56246	broad.mit.edu	37	21	33684082	33684082	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:33684082G>A	ENST00000399784.2	+	5	481	c.294G>A	c.(292-294)agG>agA	p.R98R	URB1_ENST00000382751.3_3'UTR|MRAP_ENST00000497833.1_3'UTR|MRAP_ENST00000339944.4_Intron|MRAP_ENST00000399786.3_Intron|MRAP_ENST00000303645.5_Silent_p.R98R	NM_178817.3	NP_848932.1	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	98					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			endometrium(1)|large_intestine(2)|lung(3)	6						CGTGCCACAGGGAACCCCTGG	0.632000													41	63					0	0	1	0	0
DGCR5	26220	broad.mit.edu	37	22	18979327	18979327	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18979327C>T	ENST00000438934.1	+	0	2678				DGCR5_ENST00000440005.2_RNA																							TTCTTGACCTCAGGCTGCCTC	0.547000													3	7					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450029	105450029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105450029G>A	ENST00000337685.2	+	5	1389	c.604G>A	c.(604-606)Gat>Aat	p.D202N	MUM1L1_ENST00000357175.2_Missense_Mutation_p.D202N|MUM1L1_ENST00000372552.1_Missense_Mutation_p.D202N	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	202										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						ACTTTCGGAAGATAATGATGA	0.383000													4	12					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14819258	14819258	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14819258C>T	ENST00000380881.4	-	15	3338	c.2523G>A	c.(2521-2523)tgG>tgA	p.W841*	FREM1_ENST00000380880.3_Nonsense_Mutation_p.W840*|FREM1_ENST00000422223.2_Nonsense_Mutation_p.W840*			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	840					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GGAGATCGCCCCAAGAAAATG	0.428000													16	30					0	0	1	0	0
DEF6	50619	broad.mit.edu	37	6	35289050	35289050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35289050C>T	ENST00000316637.5	+	11	1764	c.1759C>T	c.(1759-1761)Cgc>Tgc	p.R587C	DEF6_ENST00000542066.1_Missense_Mutation_p.R332C	NM_022047.3	NP_071330.3	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog (mouse)	587						cytoplasm|nucleus|plasma membrane				cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	15						GCGCCTGACCCGCTGGGGATC	0.642000													57	140					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331606	70331606	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70331606G>A	ENST00000338508.4	-	32	4794	c.4795C>T	c.(4795-4797)Cag>Tag	p.Q1599*	SHANK2_ENST00000423696.2_Nonsense_Mutation_p.Q1219*|SHANK2_ENST00000409161.1_Nonsense_Mutation_p.Q1002*|SHANK2_ENST00000449833.2_Nonsense_Mutation_p.Q1003*			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1219					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GTCCTTGGCTGGAGAACCTTG	0.577000													34	108					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72023549	72023549	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72023549G>A	ENST00000355327.3	+	10	1757	c.1623G>A	c.(1621-1623)agG>agA	p.R541R	THSD4_ENST00000261862.6_Silent_p.R541R|THSD4_ENST00000357769.4_Silent_p.R181R|THSD4_ENST00000567838.1_3'UTR			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	541						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CACCCCACAGGAGACCAGGTA	0.557000											OREG0023247	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	76					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89735049	89735049	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89735049C>T	ENST00000343435.5	-	3	726	c.190_splice	c.e3+1	p.G64_splice	RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000370459.3_Splice_Site_p.G64_splice	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	64						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		TACCACTCACCCTTGTTCTTC	0.507000													49	113					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104164979	104164979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104164979G>A	ENST00000020673.5	-	13	2884	c.2358C>T	c.(2356-2358)ttC>ttT	p.F786F	PSD_ENST00000406432.1_Silent_p.F786F	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	786	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGATCCCGTGGAAGCTCTTCC	0.667000													41	57					0	0	1	0	0
HFE2	148738	broad.mit.edu	37	1	145415632	145415632	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145415632G>A	ENST00000336751.5	+	3	689	c.451G>A	c.(451-453)Gaa>Aaa	p.E151K	HFE2_ENST00000475797.1_Intron|HFE2_ENST00000497365.1_Intron|HFE2_ENST00000357836.5_Missense_Mutation_p.E38K	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	151					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTGTGACTATGAAGGCCGGTT	0.697000													8	35					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170148796	170148796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170148796C>T	ENST00000263816.3	-	7	1021	c.736G>A	c.(736-738)Gac>Aac	p.D246N	LRP2_ENST00000443831.1_Missense_Mutation_p.D246N	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	246	LDL-receptor class A 6.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCTTTACAGTCATCTTCTCCA	0.438000													27	85					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587646	55587646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55587646G>A	ENST00000333976.4	+	1	561	c.541G>A	c.(541-543)Gag>Aag	p.E181K		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CTTCTTCTGTGAGTTCTCCTC	0.428000													46	135					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132277224	132277224	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132277224C>T	ENST00000438378.2	+	0	2293					NR_026922.1																						TCCTTACGCCCCTGGGGCGGT	0.622000													6	23					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64589979	64589979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64589979G>A	ENST00000498707.1	-	24	3845	c.3503C>T	c.(3502-3504)cCc>cTc	p.P1168L	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.P1140L	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1168					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGCAGCTGGGGGAGGATGACA	0.478000													33	68					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32751184	32751184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32751184C>T	ENST00000333070.4	+	13	1587	c.1487C>T	c.(1486-1488)cCa>cTa	p.P496L	LCK_ENST00000373564.3_Missense_Mutation_p.P473L|LCK_ENST00000336890.5_Missense_Mutation_p.P466L	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	466	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GACAACTGTCCAGAGGAGCTG	0.592000			T	TRB@	T-ALL								15	74					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971650	96971650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96971650C>T	ENST00000341686.3	+	6	896	c.771C>T	c.(769-771)ctC>ctT	p.L257L	C10orf129_ENST00000394005.3_Silent_p.L257L|C10orf129_ENST00000430183.1_Silent_p.L102L	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	257					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GGATGGATCTCCAGCCAACAG	0.473000													18	37					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50713817	50713817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50713817C>T	ENST00000440075.2	+	2	242	c.195C>T	c.(193-195)ttC>ttT	p.F65F	MYH14_ENST00000262269.8_Silent_p.F65F|MYH14_ENST00000596571.1_Silent_p.F65F|MYH14_ENST00000598205.1_Silent_p.F65F|MYH14_ENST00000601313.1_Silent_p.F65F|MYH14_ENST00000376970.2_Silent_p.F65F|MYH14_ENST00000425460.1_Silent_p.F65F			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	65	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		TTCACGGGTTCGAGGCGGCGG	0.761000													4	6					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74011530	74011530	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74011530C>T	ENST00000301607.3	-	15	2143		c.e15+1		EVPL_ENST00000586740.1_Splice_Site	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin						keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						AGAGCACTCACTTCTCCCCGT	0.667000													11	82					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99514879	99514879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:99514879G>A	ENST00000261037.3	+	5	2514	c.2134G>A	c.(2134-2136)Gac>Aac	p.D712N	COL8A1_ENST00000273342.4_Missense_Mutation_p.D712N	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	712	C1q.|Nonhelical region (NC1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						CAGGCCCGGAGACCGGGTGTT	0.537000													20	42					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141542669	141542669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:141542669G>A	ENST00000220592.5	-	18	2429	c.2317C>T	c.(2317-2319)Cgt>Tgt	p.R773C	AGO2_ENST00000519980.1_Missense_Mutation_p.R739C	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		GAGGAGAAACGATTGTCGTCC	0.517000													21	42					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110418764	110418764	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110418764C>T	ENST00000360185.4	-	7	875	c.711G>A	c.(709-711)agG>agA	p.R237R	GIT2_ENST00000338373.5_Silent_p.R237R|GIT2_ENST00000343646.5_Silent_p.R237R|GIT2_ENST00000547815.1_Silent_p.R237R|GIT2_ENST00000553118.1_Silent_p.R237R|GIT2_ENST00000551209.1_Silent_p.R237R|GIT2_ENST00000361006.5_Silent_p.R237R|TCHP_ENST00000550780.1_3'UTR|GIT2_ENST00000356259.4_Silent_p.R237R|GIT2_ENST00000355312.3_Silent_p.R237R|GIT2_ENST00000354574.4_Silent_p.R237R|GIT2_ENST00000320063.9_Silent_p.R237R|GIT2_ENST00000457474.2_Silent_p.R237R			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	237					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						CACCTGGTTTCCTGCCACAGA	0.488000													70	254					0	0	1	0	0
SEPW1	6415	broad.mit.edu	37	19	48284381	48284381	+	Missense_Mutation	SNP	C	C	T	rs11551813		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48284381C>T	ENST00000601048.1	+	4	339	c.125C>T	c.(124-126)cCc>cTc	p.P42L	SEPW1_ENST00000601419.1_3'UTR|SEPW1_ENST00000595615.1_Missense_Mutation_p.P42L|SEPW1_ENST00000509570.2_Missense_Mutation_p.P43L|SEPW1_ENST00000593892.1_Missense_Mutation_p.P42L	NM_003009.2	NP_003000.1	P63302	SELW_HUMAN	selenoprotein W, 1	42					cell redox homeostasis	cytoplasm	selenium binding			endometrium(1)|kidney(1)|lung(2)	4		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		all cancers(93;0.000291)|OV - Ovarian serous cystadenocarcinoma(262;0.000305)|Epithelial(262;0.0146)|GBM - Glioblastoma multiforme(486;0.0273)		GAGGGAACTCCCCAGGCCACC	0.572000													39	227					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132534831	132534831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132534831C>T	ENST00000265342.7	-	16	2734	c.2485G>A	c.(2485-2487)Ggt>Agt	p.G829S	CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	829						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCTTTATACCTGACACCTCA	0.592000													11	43					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141535653	141535653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141535653C>T	ENST00000264952.2	+	4	1560	c.1423C>T	c.(1423-1425)Cct>Tct	p.P475S		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	475	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						TGTGCCAGACCCTTCAGTGGT	0.428000													49	219					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38889214	38889214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38889214C>T	ENST00000302328.3	-	26	4545	c.4347G>A	c.(4345-4347)ttG>ttA	p.L1449L	SCN11A_ENST00000456224.3_Silent_p.L1411L|SCN11A_ENST00000450244.1_Silent_p.L1449L	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1449					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCTGATTTTCCAAGGTAGAAA	0.502000													4	36					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725888	140725888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140725888C>T	ENST00000253812.6	+	1	2288	c.2288C>T	c.(2287-2289)tCg>tTg	p.S763L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCGGACTCGCGGAAGAGC	0.612000													39	206					0	0	1	0	0
TRAPPC8	22878	broad.mit.edu	37	18	29493334	29493334	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29493334G>A	ENST00000283351.4	-	5	1104	c.769C>T	c.(769-771)Cag>Tag	p.Q257*	TRAPPC8_ENST00000582539.1_Nonsense_Mutation_p.Q203*|TRAPPC8_ENST00000582513.1_Nonsense_Mutation_p.Q257*	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	257					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ACATATACCTGGTTTTGAATA	0.294000													8	61					0	0	1	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142537228	142537228	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142537228G>A	ENST00000295992.3	-	9	1503	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	PCOLCE2_ENST00000485766.1_3'UTR	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	399	NTR.					extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						TCTTGGTCTTGAACATCATGA	0.378000													32	84					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85540643	85540643	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85540643C>T	ENST00000295887.5	+	5	960	c.537C>T	c.(535-537)ctC>ctT	p.L179L		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	179					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		TTCAGTTCCTCATTCGCTACC	0.313000													18	86					0	0	1	0	0
GLTPD1	80772	broad.mit.edu	37	1	1262938	1262938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1262938C>T	ENST00000343938.4	+	3	851	c.440C>T	c.(439-441)gCc>gTc	p.A147V	GLTPD1_ENST00000464957.1_3'UTR	NM_001029885.1	NP_001025056.1	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	147						cytoplasm	glycolipid binding|glycolipid transporter activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCCTCGCTGGCCGCCTACCAC	0.721000													3	10					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25150797	25150797	+	Missense_Mutation	SNP	G	G	A	rs142590557		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25150797G>A	ENST00000332271.5	-	7	1143	c.727C>T	c.(727-729)Cgc>Tgc	p.R243C	PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.R134C|PIWIL3_ENST00000533313.1_Missense_Mutation_p.R134C	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	243					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding	p.R243C(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TAATAGTTGCGACCAACTTGT	0.348000													32	98					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37406712	37406712	+	Nonsense_Mutation	SNP	G	G	A	rs147099571		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37406712G>A	ENST00000535679.1	-	4	417	c.418C>T	c.(418-420)Cga>Tga	p.R140*	SULT6B1_ENST00000407963.1_Nonsense_Mutation_p.R102*|SULT6B1_ENST00000260637.3_Nonsense_Mutation_p.R102*|SULT6B1_ENST00000379149.2_Intron			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	140						cytoplasm	sulfotransferase activity	p.R102>?(1)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				TTAGGGTTTCGAAATATCACC	0.358000													49	87					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936779	15936779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:15936779G>A	ENST00000504595.1	+	4	1441	c.960G>A	c.(958-960)gtG>gtA	p.V320V	FBXL7_ENST00000510662.1_Silent_p.V273V|FBXL7_ENST00000329673.7_Silent_p.V308V	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	320					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GCTACCTGGTGATCTACTGCG	0.672000													8	25					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37494459	37494459	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37494459C>A	ENST00000381792.2	-	3	473	c.333G>T	c.(331-333)aaG>aaT	p.K111N	TMPRSS6_ENST00000442782.2_Missense_Mutation_p.K120N|TMPRSS6_ENST00000406725.1_Missense_Mutation_p.K111N|TMPRSS6_ENST00000346753.3_Missense_Mutation_p.K120N|TMPRSS6_ENST00000406856.1_Missense_Mutation_p.K111N			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	120					angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						TTCCTACCATCTTCTGGGCTT	0.557000													121	283					4.38229e-66	4.4139e-66	1	1	0
MYO7B	4648	broad.mit.edu	37	2	128324308	128324308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128324308C>T	ENST00000389524.4	+	5	429	c.376C>T	c.(376-378)Cat>Tat	p.H126Y	MYO7B_ENST00000428314.1_Missense_Mutation_p.H126Y|MYO7B_ENST00000409816.2_Missense_Mutation_p.H126Y			Q6PIF6	MYO7B_HUMAN	myosin VIIB	126	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTACAGCCGCCATATGGGCGA	0.582000													7	24					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7846792	7846792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7846792G>A	ENST00000328375.1	-	1	727	c.728C>T	c.(727-729)tCc>tTc	p.S243F	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGTGAGGTGGGAGGTGCAGGT	0.507000													22	88					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642485	57642485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57642485G>A	ENST00000254181.4	+	4	2896	c.2442G>A	c.(2440-2442)gtG>gtA	p.V814V	USP29_ENST00000598197.1_Silent_p.V814V	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	814					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAAGAAACGTGAAGATGGGGG	0.478000													16	29					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229772297	229772297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:229772297C>T	ENST00000258243.2	+	4	2073	c.1937C>T	c.(1936-1938)tCg>tTg	p.S646L		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	646						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						AACCTCCCTTCGTTGCTCCCA	0.478000													79	255					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231077635	231077635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231077635G>A	ENST00000258381.6	-	4	501	c.424C>T	c.(424-426)Cca>Tca	p.P142S	SP110_ENST00000338556.3_5'UTR|SP110_ENST00000392048.3_Missense_Mutation_p.P142S|SP110_ENST00000540870.1_Missense_Mutation_p.P148S|SP110_ENST00000258382.5_Missense_Mutation_p.P142S|SP110_ENST00000358662.4_Missense_Mutation_p.P142S	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	142					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		GGGGGTTGTGGTGGGGGCAGC	0.577000													35	120					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54914924	54914924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54914924G>A	ENST00000293373.6	+	18	1859	c.1780G>A	c.(1780-1782)Ggt>Agt	p.G594S	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.G544S	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	594					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CAAGAACCATGGTCTTCACCA	0.537000													12	108					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50781389	50781389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50781389C>T	ENST00000440075.2	+	30	3922	c.3875C>T	c.(3874-3876)tCc>tTc	p.S1292F	MYH14_ENST00000425460.1_Missense_Mutation_p.S1259F|MYH14_ENST00000262269.8_Missense_Mutation_p.S1292F|MYH14_ENST00000376970.2_Missense_Mutation_p.S1284F|MYH14_ENST00000598205.1_Missense_Mutation_p.S1259F|MYH14_ENST00000596571.1_Missense_Mutation_p.S1251F|MYH14_ENST00000601313.1_Missense_Mutation_p.S1292F			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1251					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCCGAGGTGTCCGAGCTGCGG	0.647000													6	29					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62943454	62943454	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:62943454C>A	ENST00000393630.3	+	24	3154	c.2763C>A	c.(2761-2763)tcC>tcA	p.S921S	MON2_ENST00000552115.1_Silent_p.S920S|MON2_ENST00000393632.2_Silent_p.S920S|MON2_ENST00000552738.1_Silent_p.S897S|MON2_ENST00000280379.6_Silent_p.S921S|MON2_ENST00000393629.2_Silent_p.S920S|MON2_ENST00000546600.1_Silent_p.S920S	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	921					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TCAGAGAATCCTTGATACGAA	0.378000													14	103					1.15088e-07	1.15416e-07	1	1	0
SLC22A25	387601	broad.mit.edu	37	11	62996844	62996844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62996844G>A	ENST00000306494.6	-	1	280	c.281C>T	c.(280-282)cCc>cTc	p.P94L	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	94					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CTTCCACTGGGGATGGACAAA	0.542000													15	82					0	0	1	0	0
FAM133A	286499	broad.mit.edu	37	X	92964696	92964696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:92964696G>A	ENST00000538690.1	+	5	839	c.278G>A	c.(277-279)aGa>aAa	p.R93K	FAM133A_ENST00000332647.4_Missense_Mutation_p.R93K|FAM133A_ENST00000322139.4_Missense_Mutation_p.R93K|FAM133A_ENST00000355813.5_Missense_Mutation_p.R93K	NM_001171110.1	NP_001164581.1	Q8N9E0	F133A_HUMAN	family with sequence similarity 133, member A	93	Lys-rich.|Ser-rich.									breast(2)|endometrium(2)|large_intestine(8)|lung(7)|upper_aerodigestive_tract(1)	20						aaaagagaaagaaagaaaaag	0.318000													11	9					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32562460	32562460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:32562460C>T	ENST00000345122.3	+	2	2900	c.2585C>T	c.(2584-2586)tCg>tTg	p.S862L	ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.S862L|ARHGAP5_ENST00000539826.2_Missense_Mutation_p.S862L|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000556611.1_Missense_Mutation_p.S862L	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	862					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CGGAAAGCTTCGATGGGAATG	0.378000													17	52					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14792844	14792844	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14792844G>A	ENST00000261170.3	-	19	2245	c.2109C>T	c.(2107-2109)ccC>ccT	p.P703P		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	703	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CTGGGCGGAAGGGTTTCATTC	0.368000													7	125					0	0	1	0	0
DUS3L	56931	broad.mit.edu	37	19	5785466	5785466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5785466G>A	ENST00000309061.7	-	12	1904	c.1808C>T	c.(1807-1809)cCc>cTc	p.P603L	DUS3L_ENST00000320699.8_Missense_Mutation_p.P361L|CTB-54O9.9_ENST00000586012.1_Missense_Mutation_p.P25L	NM_020175.2	NP_064560.2	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like (S. cerevisiae)	603					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(2)	14						CAGGTAGTAGGGCGGCCGCTC	0.682000													4	5					0	0	1	0	0
FAM9A	171482	broad.mit.edu	37	X	8763148	8763148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:8763148C>T	ENST00000543214.1	-	7	937	c.802G>A	c.(802-804)Gaa>Aaa	p.E268K	FAM9A_ENST00000381003.3_Missense_Mutation_p.E268K	NM_001171186.1	NP_001164657.1	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	268	Glu-rich.					nucleolus				endometrium(11)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	18		Hepatocellular(5;0.219)				tcttcttcttcttcctcttcc	0.418000													11	9					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135561028	135561028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135561028C>T	ENST00000513104.1	-	10	2559	c.2277G>A	c.(2275-2277)caG>caA	p.Q759Q	TRPC7_ENST00000426057.2_Silent_p.Q643Q|TRPC7_ENST00000355180.3_Silent_p.Q698Q	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	759					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCATGCCAGCCTGGTAGCGAG	0.453000													10	18					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544548	186544548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186544548C>T	ENST00000431808.1	-	14	2586	c.2023G>A	c.(2023-2025)Gaa>Aaa	p.E675K	SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.E775K|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.E579K|SORBS2_ENST00000284776.7_Missense_Mutation_p.E675K			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	675						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CTGGCTCTTTCGTGTTTTAAC	0.542000													23	162					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814350	60814350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60814350C>T	ENST00000544856.2	-	7	1254	c.876G>A	c.(874-876)gaG>gaA	p.E292E	MARCH10_ENST00000583600.1_Silent_p.E331E|RP11-156L14.1_ENST00000577270.1_RNA|RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000456609.2_Silent_p.E293E|MARCH10_ENST00000311269.5_Silent_p.E293E			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	293							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						ACTGGGTTTCCTCTTCAGTGT	0.478000													37	431					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57115230	57115230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:57115230C>T	ENST00000439986.4	-	7	797	c.760G>A	c.(760-762)Ggc>Agc	p.G254S	CCBE1_ENST00000398179.2_Silent_p.G29G	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	254	Collagen-like 1.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				GGGCCCTGGCCCCCAGGCAGG	0.582000													39	90					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56031521	56031521	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56031521C>T	ENST00000309675.2	+	1	878	c.846C>T	c.(844-846)atC>atT	p.I282I		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						ACACAGTCATCACACCCATGC	0.582000													17	69					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124117716	124117716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124117716G>A	ENST00000360013.3	+	13	2465	c.2338G>A	c.(2338-2340)Gag>Aag	p.E780K	KALRN_ENST00000240874.3_Missense_Mutation_p.E780K|KALRN_ENST00000460856.1_Missense_Mutation_p.E780K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	780					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GTACACCATCGAGGTAGCAGG	0.592000													5	55					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15571068	15571068	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15571068C>T	ENST00000343625.6	-	6	688	c.606_splice	c.e6-1	p.G203_splice		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	203	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						CTTGAGCAACCCCTGTGGGGA	0.572000													5	13					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085580	9085580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9085580C>T	ENST00000397910.4	-	1	6438	c.6235G>A	c.(6235-6237)Ggg>Agg	p.G2079R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2079	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.G2079W(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTGAAACCCCAGAATGGCCT	0.473000													54	113					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23600749	23600749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23600749G>A	ENST00000316902.7	-	8	1759	c.1034C>T	c.(1033-1035)gCc>gTc	p.A345V	SLC7A8_ENST00000529705.2_Missense_Mutation_p.A240V|SLC7A8_ENST00000469263.1_Intron|SLC7A8_ENST00000453702.1_Missense_Mutation_p.A142V|SLC7A8_ENST00000422941.2_Missense_Mutation_p.A121V	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	345					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	GCCCTCTCGGGCTCCAGCGAA	0.602000													10	35					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15586491	15586491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15586491G>A	ENST00000292609.4	-	2	1119	c.990C>T	c.(988-990)tcC>tcT	p.S330S	PGLYRP2_ENST00000340880.4_Silent_p.S330S			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	330					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GGGCCAGGATGGAGGCTGAAG	0.617000													16	40					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398676	89398676	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89398676C>T	ENST00000439576.2	+	12	3234	c.2860C>T	c.(2860-2862)Ctc>Ttc	p.L954F	ACAN_ENST00000352105.7_Missense_Mutation_p.L954F|ACAN_ENST00000559004.1_Missense_Mutation_p.L954F|ACAN_ENST00000561243.1_Missense_Mutation_p.L954F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	954					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTTGGGGATCTCAGTGGACT	0.557000													75	108					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417474	150417474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150417474G>A	ENST00000307194.5	+	3	522	c.382G>A	c.(382-384)Gac>Aac	p.D128N		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACCGCCCAGGACCAGCAGGC	0.647000													7	53					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9488924	9488924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9488924C>T	ENST00000402466.1	+	15	2189	c.1421C>T	c.(1420-1422)tCa>tTa	p.S474L	SETD5_ENST00000406341.1_Missense_Mutation_p.S572L|SETD5_ENST00000402198.1_Missense_Mutation_p.S572L|SETD5_ENST00000407969.1_Missense_Mutation_p.S591L|SETD5_ENST00000302463.6_Missense_Mutation_p.S474L			Q9C0A6	SETD5_HUMAN	SET domain containing 5	572										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AACTCTGTTTCAAATGTTACC	0.458000													61	139					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839623	15839623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15839623C>T	ENST00000305899.3	+	1	790	c.770C>T	c.(769-771)tCt>tTt	p.S257F		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GGCTTTGCCTCTGTCATCTAC	0.562000													29	111					0	0	1	0	0
CXCR2P1	3580	broad.mit.edu	37	2	218925373	218925373	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:218925373G>A	ENST00000439871.1	-	0	1007					NR_002712.1																						AGGAAAATGAGGACAACAGCA	0.547000													8	75					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	549866	549866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:549866C>T	ENST00000239830.4	+	11	1304	c.1125C>T	c.(1123-1125)gcC>gcT	p.A375A	CCDC77_ENST00000422000.1_Silent_p.A343A|CCDC77_ENST00000540180.1_Silent_p.A343A|CCDC77_ENST00000412006.2_Silent_p.A343A	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	375						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			AAGAACTTGCCCGAATTCGTG	0.433000													20	67					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687851	68687851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:68687851C>T	ENST00000361320.4	+	2	1755	c.1177C>T	c.(1177-1179)Ccc>Tcc	p.P393S	CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	393						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TGAGAGCAAACCCCCTTTGCC	0.597000													23	74					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36054167	36054167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36054167C>T	ENST00000262623.3	-	3	188	c.160G>A	c.(160-162)Gac>Aac	p.D54N		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	54					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AGCTGGTGGTCGTTCTGTGTG	0.652000													69	188					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95480886	95480886	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95480886C>T	ENST00000432432.2	-	0	2474					NR_040113.1																						TGATCACATTCATTCATTAGC	0.323000													40	116					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57670611	57670611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57670611G>A	ENST00000554048.2	-	3	215	c.216C>T	c.(214-216)ttC>ttT	p.F72F		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	72						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		GTCTTTTCTGGAATCCGTGCC	0.418000													29	95					0	0	1	0	0
KRT84	3890	broad.mit.edu	37	12	52775247	52775247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52775247G>A	ENST00000257951.3	-	5	1041	c.975C>T	c.(973-975)agC>agT	p.S325S	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	325	Linker 12.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCAGGTCACGGCTGTTGTCCA	0.557000													85	162					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33703677	33703677	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33703677C>T	ENST00000336934.5	-	5	1253	c.1137G>A	c.(1135-1137)ggG>ggA	p.G379G	STARD13_ENST00000255486.4_Silent_p.G371G|STARD13_ENST00000399365.3_Silent_p.G261G	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	379					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GGCTTTGGTCCCCTGCATCCG	0.547000													22	104					0	0	1	0	0
USP38	84640	broad.mit.edu	37	4	144133528	144133528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:144133528C>T	ENST00000307017.4	+	8	2061	c.1555C>T	c.(1555-1557)Ccc>Tcc	p.P519S	USP38_ENST00000510377.1_Missense_Mutation_p.P519S	NM_032557.5	NP_115946.2	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	519					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					ATGGTTTACTCCCAGATCACA	0.378000													23	93					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46244896	46244896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46244896G>A	ENST00000296140.3	-	2	1034	c.909C>T	c.(907-909)ttC>ttT	p.F303F	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	303					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		TCTCACCAACGAAGGCGTAGA	0.582000													17	30					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21727167	21727167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21727167G>A	ENST00000261195.2	-	4	843	c.589C>T	c.(589-591)Cct>Tct	p.P197S		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	197					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GTGGCAATAGGAAGTTTCCTG	0.418000													14	84					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155451384	155451384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155451384G>A	ENST00000368346.3	-	3	1916	c.1277C>T	c.(1276-1278)gCc>gTc	p.A426V	ASH1L_ENST00000548830.1_3'UTR|ASH1L_ENST00000392403.3_Missense_Mutation_p.A426V			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	426					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CAGTGCTTCGGCTTTAAGGTT	0.418000													46	81					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31793040	31793040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31793040C>T	ENST00000396193.1	-	19	2861	c.2268G>A	c.(2266-2268)atG>atA	p.M756I	PDE1C_ENST00000396191.1_Missense_Mutation_p.M696I|PDE1C_ENST00000321453.7_Missense_Mutation_p.M696I	NM_001191058.1	NP_001177987.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	696					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GAATCTTTTTCATTTTGATCC	0.468000													102	284					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187333	123187333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123187333C>T	ENST00000328880.5	-	1	557	c.498G>A	c.(496-498)aaG>aaA	p.K166K	RP11-324E6.6_ENST00000543611.1_lincRNA|HCAR1_ENST00000356987.2_Intron	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	166					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	GGATCGGCATCTTCTTCTTCA	0.537000													23	66					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158746540	158746540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158746540C>T	ENST00000339258.1	-	1	885	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					TTAATGATTTCCTTGTTACGA	0.408000													42	174					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56574793	56574793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56574793G>A	ENST00000394023.3	-	11	1154	c.1049C>T	c.(1048-1050)cCc>cTc	p.P350L	RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Missense_Mutation_p.P350L|SMARCC2_ENST00000347471.4_Missense_Mutation_p.P350L|SMARCC2_ENST00000267064.4_Missense_Mutation_p.P350L	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	350					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TTCTACATTGGGGACTGGTGA	0.557000													31	181					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20915772	20915772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20915772C>T	ENST00000375071.3	+	1	332	c.150C>T	c.(148-150)ttC>ttT	p.F50F	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	50					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	GGAGAATCTTCAAAGGTAAAG	0.622000													12	36					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90503081	90503081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90503081G>A	ENST00000325643.5	+	4	3745	c.3679G>A	c.(3679-3681)Gcc>Acc	p.A1227T		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GACCTCTGAAGCCAGTGGGAG	0.597000													4	26					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141619083	141619083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141619083G>A	ENST00000548136.1	+	1	467	c.408G>A	c.(406-408)atG>atA	p.M136I	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					ACATCATTATGAACAGACACA	0.458000													77	157					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118147569	118147569	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:118147569G>A	ENST00000456015.2	+	1	3	c.3G>A	c.(1-3)atG>atA	p.M1I	SLC30A8_ENST00000521243.1_Intron|SLC30A8_ENST00000427715.2_5'UTR|SLC30A8_ENST00000521035.1_3'UTR|SLC30A8_ENST00000519688.1_5'UTR	NM_173851.2	NP_776250.2	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	1					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity	p.M1I(1)		breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TGGCCGTCATGGAGTTTCTTG	0.413000													46	135					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272747	81272747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81272747C>T	ENST00000520547.2	+	1	391	c.342C>T	c.(340-342)ctC>ctT	p.L114L		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	114					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			ACCTTCGTCTCCCTGAGGGAG	0.547000													25	137					0	0	1	0	0
OR13C9	286362	broad.mit.edu	37	9	107380046	107380046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107380046C>T	ENST00000259362.1	-	1	439	c.440G>A	c.(439-441)gGg>gAg	p.G147E		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						AAACCAGGACCCAACAGCCAT	0.453000													51	91					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35550838	35550838	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35550838C>T	ENST00000262626.2	+	6	1176	c.351C>T	c.(349-351)ttC>ttT	p.F117F	HPN_ENST00000600675.1_3'UTR|HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Intron|HPN_ENST00000392226.1_Silent_p.F117F	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	117	SRCR.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	CGTCGGGCTTCTTCTGTGTGG	0.697000													6	13					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263334	39263334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39263334C>T	ENST00000280481.7	+	1	2069	c.1853C>T	c.(1852-1854)cCc>cTc	p.P618L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	618					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ACTCACCCTCCCCATGAGAAG	0.522000													5	78					0	0	1	0	0
NMUR1	10316	broad.mit.edu	37	2	232393203	232393203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:232393203G>A	ENST00000305141.4	-	2	662	c.529C>T	c.(529-531)Cat>Tat	p.H177Y		NM_006056.4	NP_006047.3	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	177					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(12)|pancreas(1)|skin(1)	24		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CGGCGCACATGGGCCCGCGTC	0.682000													21	45					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80044354	80044354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80044354G>A	ENST00000306749.2	-	22	3726	c.3508C>T	c.(3508-3510)Ccc>Tcc	p.P1170S		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1170					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGGTCCCGGGGGATCTGGGCC	0.687000													12	31					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37462938	37462938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37462938C>T	ENST00000381792.2	-	18	2384	c.2244G>A	c.(2242-2244)gaG>gaA	p.E748E	TMPRSS6_ENST00000406725.1_Silent_p.E726E|TMPRSS6_ENST00000346753.3_Silent_p.E735E|TMPRSS6_ENST00000406856.1_Silent_p.E748E			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	735	Peptidase S1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						AGCGATAGACCTCGCTGCACA	0.607000													16	29					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114275491	114275491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114275491C>T	ENST00000357077.4	+	38	5770	c.5717C>T	c.(5716-5718)cCt>cTt	p.P1906L	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.P1873L|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1873	Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCTGTTTCGCCTTCAGGCAAA	0.488000													22	67					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176998797	176998797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176998797G>A	ENST00000367654.2	-	5	1106	c.1093C>T	c.(1093-1095)Cct>Tct	p.P365S	ASTN1_ENST00000424564.2_Missense_Mutation_p.P365S|ASTN1_ENST00000367657.3_Missense_Mutation_p.P365S|ASTN1_ENST00000361833.2_Missense_Mutation_p.P365S|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	365					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CTCCTTGAAGGATCCGTGTAA	0.552000													7	34					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640348	179640348	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179640348G>A	ENST00000589042.1	-	28	6467	c.6243C>T	c.(6241-6243)ttC>ttT	p.F2081F	TTN_ENST00000342992.6_Silent_p.F2081F|TTN_ENST00000360870.5_Silent_p.F2081F|TTN_ENST00000591111.1_Silent_p.F2081F|TTN_ENST00000342175.6_Silent_p.F2035F|TTN_ENST00000359218.5_Silent_p.F2035F|TTN_ENST00000460472.2_Silent_p.F2035F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1844	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.F2035L(3)|p.F2081L(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGATTCTTTCGAAGATTTTTG	0.453000													29	73					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28537606	28537606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:28537606G>A	ENST00000401766.2	-	10	1888	c.1376C>T	c.(1375-1377)gCc>gTc	p.A459V	SLC6A4_ENST00000261707.3_Missense_Mutation_p.A459V			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	459					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CCGGCGCTTGGCCCAGACGTG	0.592000													8	72					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711301	20711301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20711301G>A	ENST00000315409.2	+	1	404	c.351G>A	c.(349-351)ctG>ctA	p.L117L		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		TCTTTTCACTGGGAACAACTG	0.463000													21	95					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100055656	100055656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:100055656G>A	ENST00000258428.3	-	6	848	c.620C>T	c.(619-621)tCt>tTt	p.S207F	REV1_ENST00000393445.3_Missense_Mutation_p.S207F|REV1_ENST00000465835.1_5'UTR	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	207					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCTTCCCGGAGAGGTCTGCTC	0.418000								Direct reversal of damage					11	49					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36348040	36348040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36348040C>T	ENST00000360202.5	+	1	217	c.19C>T	c.(19-21)Ccc>Tcc	p.P7S	NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000586102.2_Missense_Mutation_p.P7S|KIRREL2_ENST00000347900.6_Missense_Mutation_p.P7S|KIRREL2_ENST00000262625.7_Missense_Mutation_p.P7S|KIRREL2_ENST00000592409.1_Missense_Mutation_p.P7S	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	7					cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GATGCGGGTCCCCGCCCTCCT	0.632000													20	47					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1268686	1268686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1268686G>A	ENST00000447027.1	+	31	10643	c.10585G>A	c.(10585-10587)Ggg>Agg	p.G3529R	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.G3526R			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3526	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCTTCTCCAGGGACGACCAC	0.687000													25	101					0	0	1	0	0
MYOZ1	58529	broad.mit.edu	37	10	75399765	75399765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75399765G>A	ENST00000359322.4	-	2	375	c.11C>T	c.(10-12)tCa>tTa	p.S4L		NM_021245.3	NP_067068.1	Q9NP98	MYOZ1_HUMAN	myozenin 1	4					myofibril assembly	nucleus|pseudopodium	FATZ binding			central_nervous_system(1)|large_intestine(5)|lung(2)|ovary(2)|skin(2)	12	Prostate(51;0.0112)					CGGGGTTCCTGAGAGCGGCAT	0.542000													14	98					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110301041	110301041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110301041G>A	ENST00000369805.3	-	8	846	c.617C>T	c.(616-618)tCc>tTc	p.S206F	EPS8L3_ENST00000494151.1_5'UTR|EPS8L3_ENST00000361965.4_Missense_Mutation_p.S205F|RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361852.4_Missense_Mutation_p.S205F	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	205	Pro-rich.					cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GGGCCTTGGGGATGGTGGGAG	0.597000													15	185					0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41033272	41033272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41033272C>T	ENST00000380620.3	+	5	1378	c.786C>T	c.(784-786)tcC>tcT	p.S262S	AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000343118.4_Silent_p.S262S|B3GALT5_ENST00000380618.1_Silent_p.S262S|B3GALT5_ENST00000398714.2_Silent_p.S262S			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	262					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				AGCTCCACTCCCAGCCGACCT	0.532000													58	96					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17657536	17657536	+	Silent	SNP	C	C	T	rs77182432	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17657536C>T	ENST00000375448.4	+	2	191	c.165C>T	c.(163-165)ggC>ggT	p.G55G	PADI4_ENST00000375453.1_Silent_p.G55G|AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	55			G -> S (in dbSNP:rs11203366).		chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	TTGCCCACGGCCCTCCAGCCA	0.602000													23	45					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183710312	183710312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183710312G>A	ENST00000511685.1	+	25	5494	c.5371G>A	c.(5371-5373)Gac>Aac	p.D1791N	TENM3_ENST00000406950.2_Missense_Mutation_p.D1791N					teneurin transmembrane protein 3																		GATCTATGACGACCACCGTAA	0.453000													5	16					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37975632	37975632	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37975632C>T	ENST00000330173.1	+	5	1637	c.1108C>T	c.(1108-1110)Cgt>Tgt	p.R370C	ZNF570_ENST00000388801.3_Missense_Mutation_p.R167C|ZNF570_ENST00000586475.1_Missense_Mutation_p.R426C	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTTAGCCTTCGTGCATACCT	0.428000													8	96					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430764	135430764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135430764G>A	ENST00000394143.1	+	6	5190	c.4899G>A	c.(4897-4899)atG>atA	p.M1633I	GPR112_ENST00000370652.1_Missense_Mutation_p.M1633I|GPR112_ENST00000394141.1_Missense_Mutation_p.M1428I|GPR112_ENST00000412101.1_Missense_Mutation_p.M1428I|GPR112_ENST00000287534.4_Missense_Mutation_p.M1570I	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1633					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTACAGAAATGATAGAGGCAC	0.448000													66	53					0	0	1	0	0
FAM19A4	151647	broad.mit.edu	37	3	68802034	68802034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:68802034G>A	ENST00000295569.7	-	4	758	c.266C>T	c.(265-267)gCt>gTt	p.A89V		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	89						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		AGAAGGTTGAGCCCGAGTTGT	0.517000													28	85					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33565900	33565900	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33565900G>A	ENST00000262873.7	+	3	309		c.e3+1			NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta							membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CCATGGGACGGTAAGTGGAGA	0.602000													15	52					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43926790	43926790	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43926790G>A	ENST00000282406.4	+	8	803	c.693G>A	c.(691-693)atG>atA	p.M231I		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	231						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTCTAGAAATGGAAATTCCAG	0.368000													23	54					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95518576	95518576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95518576C>T	ENST00000371418.4	+	2	535	c.275C>T	c.(274-276)tCg>tTg	p.S92L	LGI1_ENST00000371413.3_Missense_Mutation_p.S92L|LGI1_ENST00000478763.1_3'UTR|LGI1_ENST00000542308.1_Missense_Mutation_p.S92L	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	92					axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				TTCACGCCATCGCTGCAGCTC	0.313000													30	52					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3675457	3675457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3675457C>T	ENST00000344754.4	-	11	2796	c.2797G>A	c.(2797-2799)Gat>Aat	p.D933N	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.D933N	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	933	Ig-like C2-type 9.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGCTGGCCATCCCGATACCAA	0.617000													26	56					0	0	1	0	0
LCN9	392399	broad.mit.edu	37	9	138555222	138555222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138555222G>A	ENST00000277526.3	+	1	55	c.55G>A	c.(55-57)Gat>Aat	p.D19N	LCN9_ENST00000430290.2_3'UTR	NM_001001676.1	NP_001001676.1	Q8WX39	LCN9_HUMAN	lipocalin 9	19						extracellular region	pheromone binding|transporter activity			kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	6		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		CCAGGAGTTCGATCCCCACAC	0.627000													14	56					0	0	1	0	0
BDH1	622	broad.mit.edu	37	3	197239115	197239115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:197239115G>A	ENST00000392379.1	-	8	1084	c.683C>T	c.(682-684)cCc>cTc	p.P228L	BDH1_ENST00000358186.2_Missense_Mutation_p.P228L|BDH1_ENST00000392378.2_Missense_Mutation_p.P228L|BDH1_ENST00000441275.1_Missense_Mutation_p.P141L	NM_203314.2	NP_976059.1	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	228					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	CACGCCCAGGGGGTACATCTC	0.622000													19	25					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125109512	125109512	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125109512G>A	ENST00000522917.1	+	36	4902	c.4695_splice	c.e36-1	p.G1566_splice	FER1L6_ENST00000399018.1_Splice_Site_p.G1566_splice|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1566						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTTAACAAGGGCCGCCTGCA	0.453000													10	113					0	0	1	0	0
LCP2	3937	broad.mit.edu	37	5	169720347	169720347	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169720347C>T	ENST00000046794.5	-	2	723	c.108G>A	c.(106-108)gtG>gtA	p.V36V		NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	36	SAM.				immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		GGTACTTCTTCACTGCCTTCT	0.522000													10	15					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141619380	141619380	+	Silent	SNP	G	G	A	rs143629932		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141619380G>A	ENST00000548136.1	+	1	764	c.705G>A	c.(703-705)agG>agA	p.R235R	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R235R(1)		NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					CTGGCCGGAGGAAATCCTTCT	0.502000													45	105					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111215776	111215776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111215776G>A	ENST00000369769.2	-	1	1879	c.1656C>T	c.(1654-1656)tcC>tcT	p.S552S		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	552						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGGTGGCAGTGGAATTGCCCG	0.463000													37	128					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107923951	107923951	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107923951C>T	ENST00000328300.6	+	45	4229	c.3985C>T	c.(3985-3987)Cct>Tct	p.P1329S	COL4A5_ENST00000361603.2_Missense_Mutation_p.P1323S	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1323	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GAAAGGAGATCCTGGTCTCCC	0.428000									Alport syndrome with Diffuse Leiomyomatosis				23	13					0	0	1	0	0
PATL1	219988	broad.mit.edu	37	11	59423479	59423479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59423479G>A	ENST00000300146.9	-	7	847	c.763C>T	c.(763-765)Cct>Tct	p.P255S		NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	255	Pro-rich.|Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						AGAACAGGAGGAACACTAGGA	0.428000													5	13					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003641	34003641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34003641G>A	ENST00000374181.3	-	8	2415	c.2246C>T	c.(2245-2247)tCg>tTg	p.S749L	GRM4_ENST00000455714.2_Missense_Mutation_p.S609L|GRM4_ENST00000535756.1_Missense_Mutation_p.S616L|GRM4_ENST00000544773.1_Missense_Mutation_p.S580L|GRM4_ENST00000545715.1_Missense_Mutation_p.S441L|GRM4_ENST00000374177.3_Missense_Mutation_p.S633L|GRM4_ENST00000538487.1_Missense_Mutation_p.S749L	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	749					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CGACAGGTCCGAGATGTCACA	0.617000													12	66					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46122066	46122066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46122066G>A	ENST00000374366.3	-	8	1448	c.983C>T	c.(982-984)gCt>gTt	p.A328V	ZFAND4_ENST00000374370.1_5'UTR|ZFAND4_ENST00000374371.2_Intron|ZFAND4_ENST00000344646.5_Missense_Mutation_p.A402V			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	402							zinc ion binding										TGCAAATGAAGCCAGTGAGCC	0.433000													45	103					0	0	1	0	0
SLC22A17	51310	broad.mit.edu	37	14	23817773	23817773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23817773C>T	ENST00000354772.3	-	5	1137	c.634G>A	c.(634-636)Gat>Aat	p.D212N	SLC22A17_ENST00000474057.1_Intron|SLC22A17_ENST00000397260.3_Missense_Mutation_p.D101N|SLC22A17_ENST00000397267.1_Missense_Mutation_p.D212N|SLC22A17_ENST00000206544.8_Missense_Mutation_p.D212N	NM_016609.3	NP_057693.3	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17	212					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		AATCGCCAATCCTTAGAGACA	0.587000													43	112					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150647386	150647386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150647386C>T	ENST00000392968.2	-	7	3100	c.1980G>A	c.(1978-1980)atG>atA	p.M660I	KCNH2_ENST00000430723.3_Missense_Mutation_p.M756I|KCNH2_ENST00000262186.5_Missense_Mutation_p.M756I|KCNH2_ENST00000330883.4_Missense_Mutation_p.M416I			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	756					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TCTTGAACTTCATGGCCAGGG	0.637000													8	85					0	0	1	0	0
ZNF200	7752	broad.mit.edu	37	16	3274129	3274129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3274129G>A	ENST00000431561.3	-	5	1563	c.951C>T	c.(949-951)ttC>ttT	p.F317F	ZNF200_ENST00000396870.4_Silent_p.F316F|ZNF200_ENST00000575948.1_Silent_p.F316F|AJ003147.9_ENST00000576468.1_RNA|ZNF200_ENST00000396868.3_Silent_p.F316F|ZNF200_ENST00000414144.2_Silent_p.F317F|ZNF200_ENST00000396871.4_Silent_p.F316F	NM_001145447.1|NM_003454.3	NP_001138919.1|NP_003445.2	P98182	ZN200_HUMAN	zinc finger protein 200	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	17						AATTCTGACGGAAGTTTTTTC	0.393000													118	81					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34064165	34064165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34064165G>A	ENST00000389232.4	+	63	8931	c.8861G>A	c.(8860-8862)cGa>cAa	p.R2954Q	RYR3_ENST00000415757.3_Missense_Mutation_p.R2954Q	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2954					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTGGGTTACGAGCATTCTTT	0.443000													7	20					0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048030	6048030	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6048030C>T	ENST00000316650.5	-	1	941	c.905G>A	c.(904-906)cGg>cAg	p.R302Q		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTTTGGTCCGAACCCCATA	0.448000													8	82					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62887153	62887153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:62887153G>A	ENST00000281156.4	-	2	434	c.156C>T	c.(154-156)gtC>gtT	p.V52V		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	52					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TGTTGCTGATGACATCAAGAT	0.328000													14	32					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10464881	10464881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10464881C>T	ENST00000382483.3	-	4	6950	c.6727G>A	c.(6727-6729)Gga>Aga	p.G2243R		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2243					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TGAGTTTCTCCTTCTGACTCT	0.602000													45	146					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146673593	146673593	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:146673593A>T	ENST00000392299.2	+	5	1864	c.1394A>T	c.(1393-1395)gAg>gTg	p.E465V	GRM1_ENST00000355289.4_Missense_Mutation_p.E465V|GRM1_ENST00000492807.2_Missense_Mutation_p.E465V|GRM1_ENST00000282753.1_Missense_Mutation_p.E465V|GRM1_ENST00000507907.1_Missense_Mutation_p.E465V|GRM1_ENST00000361719.2_Missense_Mutation_p.E465V			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	465					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GTATCTGGAGAGGAGGTGTGG	0.522000													45	126					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62398592	62398592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62398592G>A	ENST00000346178.4	-	11	1141	c.1126C>T	c.(1126-1128)Cgc>Tgc	p.R376C	GANAB_ENST00000534779.1_Missense_Mutation_p.R262C|GANAB_ENST00000356638.3_Missense_Mutation_p.R354C|GANAB_ENST00000540933.1_Missense_Mutation_p.R257C	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	354					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GACATCCAGCGAACATCTGTC	0.537000													78	285					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242383356	242383356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:242383356G>A	ENST00000442594.2	-	6	902	c.393C>T	c.(391-393)ttC>ttT	p.F131F	PLD5_ENST00000427495.1_Silent_p.F161F|PLD5_ENST00000536534.1_Silent_p.F223F	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	223						integral to membrane	catalytic activity	p.F223L(1)|p.F131L(1)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CCACGATCCAGAAGGAGGACT	0.522000													8	62					0	0	1	0	0
HOXC10	3226	broad.mit.edu	37	12	54379110	54379110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54379110G>A	ENST00000303460.4	+	1	141	c.67G>A	c.(67-69)Gag>Aag	p.E23K	HOXC-AS3_ENST00000514702.1_RNA	NM_017409.3	NP_059105.2	Q9NYD6	HXC10_HUMAN	homeobox C10	23					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(14)|pancreas(1)	20						CGGCGGAGGAGAGCGCTATAG	0.587000													46	100					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058360	9058360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9058360C>T	ENST00000397910.4	-	3	29289	c.29086G>A	c.(29086-29088)Gga>Aga	p.G9696R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9698	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGAAAGTCCTTGAGACATA	0.493000													17	54					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13769225	13769225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13769225C>T	ENST00000265104.4	-	58	9845	c.9741G>A	c.(9739-9741)atG>atA	p.M3247I	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3247	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCTGTGCTTTCATTGTCACTT	0.418000									Kartagener syndrome				93	222					0	0	1	0	0
MAPK4	5596	broad.mit.edu	37	18	48255634	48255634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:48255634G>A	ENST00000400384.2	+	6	2210	c.1174G>A	c.(1174-1176)Gac>Aac	p.D392N	MAPK4_ENST00000540640.1_Missense_Mutation_p.D181N|MAPK4_ENST00000592595.1_3'UTR	NM_002747.3	NP_002738.2	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	392					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(3)|upper_aerodigestive_tract(1)	8		Colorectal(6;0.0297)		Colorectal(21;0.156)		ACTGGCTGAGGACGTGCAGGT	0.701000													8	26					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32198639	32198639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32198639G>A	ENST00000373658.3	-	26	3899	c.3558C>T	c.(3556-3558)ctC>ctT	p.L1186L	BAI2_ENST00000398556.3_Silent_p.L1101L|BAI2_ENST00000257070.4_Silent_p.L1153L|BAI2_ENST00000465256.1_5'UTR|BAI2_ENST00000398538.1_Silent_p.L1174L|BAI2_ENST00000527361.1_Silent_p.L1153L|BAI2_ENST00000440175.2_Silent_p.L795L|BAI2_ENST00000398542.1_Silent_p.L1086L|BAI2_ENST00000398547.1_Silent_p.L1119L|BAI2_ENST00000373655.2_Silent_p.L1186L	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1186					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		AGACAGCAAAGAGGGCCTGGA	0.647000													5	6					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445109	49445109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49445109G>A	ENST00000301067.7	-	10	2356	c.2357C>T	c.(2356-2358)cCa>cTa	p.P786L		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGACAAGTGTGGCTCCTCAGG	0.657000													17	32					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36370284	36370284	+	Missense_Mutation	SNP	G	G	A	rs147200750		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36370284G>A	ENST00000221891.4	+	17	2089	c.1897G>A	c.(1897-1899)Gaa>Aaa	p.E633K	APLP1_ENST00000537454.2_Missense_Mutation_p.E593K|APLP1_ENST00000586861.1_Missense_Mutation_p.E626K	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	632					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCAGCTCCGCGAACTGCAGCG	0.672000													30	96					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215807923	215807923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215807923G>A	ENST00000366943.2	-	70	15561	c.15175C>T	c.(15175-15177)Ctg>Ttg	p.L5059L	USH2A_ENST00000307340.3_Silent_p.L5059L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5059					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATCAGGGACAGAAAAATGGCC	0.438000										HNSCC(13;0.011)			7	113					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66258726	66258726	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66258726C>T	ENST00000532677.1	+	7	1128	c.727C>T	c.(727-729)Cct>Tct	p.P243S	DPP3_ENST00000541961.1_Missense_Mutation_p.P224S|DPP3_ENST00000531863.1_Missense_Mutation_p.P244S|DPP3_ENST00000360510.2_Missense_Mutation_p.P224S|DPP3_ENST00000530165.1_Missense_Mutation_p.P194S|DPP3_ENST00000453114.1_Missense_Mutation_p.P224S	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	224					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TTCCCCAGAGCCTTCCCTGGA	0.552000											OREG0021109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	161					0	0	1	0	0
APOL3	80833	broad.mit.edu	37	22	36538042	36538042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36538042C>T	ENST00000397293.2	-	4	549	c.202G>A	c.(202-204)Gaa>Aaa	p.E68K	APOL3_ENST00000424878.2_5'UTR|APOL3_ENST00000397287.2_5'UTR|APOL3_ENST00000349314.2_Missense_Mutation_p.E139K|APOL3_ENST00000361710.2_5'UTR|APOL3_ENST00000487423.1_5'UTR			O95236	APOL3_HUMAN	apolipoprotein L, 3	139					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity			endometrium(2)|large_intestine(1)|lung(1)|stomach(1)	5						TGCACATATTCGTCCTCAATA	0.438000													30	62					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64136112	64136112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:64136112G>A	ENST00000395254.3	+	2	440	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	ZNF365_ENST00000466727.1_Intron|ZNF365_ENST00000395255.3_Missense_Mutation_p.E54K|ZNF365_ENST00000410046.3_Missense_Mutation_p.E54K	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					TCACAGCTACGAAGAAAGAAC	0.498000													8	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179443794	179443794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179443794C>T	ENST00000589042.1	-	320	68187	c.67963G>A	c.(67963-67965)Gaa>Aaa	p.E22655K	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E20087K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E21014K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E13782K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E13715K|TTN-AS1_ENST00000592600.1_RNA|RP11-171I2.2_ENST00000603521.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E13590K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21014	Fibronectin type-III 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTGACTTCATCAAATTTG	0.453000													25	36					0	0	1	0	0
SLC16A13	201232	broad.mit.edu	37	17	6940077	6940077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6940077C>T	ENST00000308027.6	+	2	539	c.231C>T	c.(229-231)ttC>ttT	p.F77F		NM_201566.2	NP_963860.1	Q7RTY0	MOT13_HUMAN	solute carrier family 16, member 13	77						integral to membrane|plasma membrane	symporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						GCACGAAGTTCGGGCCCAGGC	0.632000													15	112					0	0	1	0	0
TBC1D13	54662	broad.mit.edu	37	9	131559401	131559401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131559401C>T	ENST00000372648.5	+	7	601	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	TBC1D13_ENST00000539497.1_5'UTR|TBC1D13_ENST00000223865.8_Missense_Mutation_p.P151S|TBC1D13_ENST00000466056.1_3'UTR	NM_018201.3	NP_060671.3	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	151	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	6						CATCCTGGACCCCCAGAATGA	0.517000													29	108					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120802039	120802039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:120802039G>A	ENST00000369144.3	-	19	3120	c.2993C>T	c.(2992-2994)cCc>cTc	p.P998L	EIF3A_ENST00000541549.1_Missense_Mutation_p.P964L|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	998	25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].|Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AATTCGTCTGGGAGGCCTGTC	0.572000													19	208					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121485641	121485641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121485641G>A	ENST00000260197.7	+	41	5610	c.5481G>A	c.(5479-5481)ggG>ggA	p.G1827G	SORL1_ENST00000527934.1_Silent_p.G442G|SORL1_ENST00000525532.1_Silent_p.G771G|SORL1_ENST00000532694.1_Silent_p.G673G|SORL1_ENST00000534286.1_Silent_p.G737G	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1827	Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CTGACTTGGGGGATAGCCCTC	0.512000													47	107					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50266392	50266392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50266392C>T	ENST00000246801.3	-	1	195	c.113G>A	c.(112-114)aGg>aAg	p.R38K		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	38							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GCTGGTCACCCTCCGGGGAGC	0.622000													46	101					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158500435	158500435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:158500435C>T	ENST00000313708.6	-	6	805	c.523G>A	c.(523-525)Gag>Aag	p.E175K	EBF1_ENST00000380654.4_Intron|EBF1_ENST00000517373.1_Missense_Mutation_p.E175K|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	175					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAGGGAGTCTCATTTCGGTTG	0.418000			T	HMGA2	lipoma								60	115					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55534823	55534823	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55534823A>T	ENST00000220676.1	+	3	910	c.762A>T	c.(760-762)ggA>ggT	p.G254G		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	254					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACCCCAAGGGAAATGCAAAGT	0.413000													23	63					0	0	1	0	0
OR2H2	7932	broad.mit.edu	37	6	29555752	29555752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29555752C>T	ENST00000383640.2	+	1	70	c.31C>T	c.(31-33)Ctc>Ttc	p.L11F	GABBR1_ENST00000355973.3_Intron	NM_007160.3	NP_009091.3	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H, member 2	11					defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	14						ACCGGGCTTCCTCCTTCTGGG	0.512000													58	150					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111060399	111060399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111060399C>T	ENST00000369771.2	-	1	1398	c.1011G>A	c.(1009-1011)ctG>ctA	p.L337L		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	337						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TCAGGATGGCCAGGGACATGT	0.547000													43	142					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106918652	106918652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106918652C>T	ENST00000369701.3	+	11	1859	c.1632C>T	c.(1630-1632)ccC>ccT	p.P544P		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	544						integral to membrane	neuropeptide receptor activity	p.P544P(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CATTTTAGCCCTTCTGTTCCT	0.478000													21	72					0	0	1	0	0
PRKCH	5583	broad.mit.edu	37	14	61924237	61924237	+	Missense_Mutation	SNP	G	G	A	rs61740172	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:61924237G>A	ENST00000332981.5	+	9	1503	c.1118G>A	c.(1117-1119)aGa>aAa	p.R373K	PRKCH_ENST00000555082.1_Missense_Mutation_p.R212K	NM_006255.3	NP_006246.2	P24723	KPCL_HUMAN	protein kinase C, eta	373	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		ATGCTTGCAAGAGTAAAAGAA	0.488000													15	193					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86814879	86814879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86814879G>A	ENST00000441037.2	+	14	1974	c.1879G>A	c.(1879-1881)Gag>Aag	p.E627K	AGBL1_ENST00000389298.3_Missense_Mutation_p.E358K|AGBL1_ENST00000421325.2_Missense_Mutation_p.E627K	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	627					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TTCTGTGAAGGAGGCTCTTCT	0.443000													22	126					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345675	92345675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:92345675C>T	ENST00000377067.3	+	3	932	c.560C>T	c.(559-561)tCc>tTc	p.S187F		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	187						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ACTGACAGTTCCCTGGAATAC	0.473000													85	114					0	0	1	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698666	111698666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:111698666C>T	ENST00000340433.2	+	1	940	c.710C>T	c.(709-711)tCc>tTc	p.S237F		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	237							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						TTGTTGGCTTCCTTGATCCAA	0.532000													94	78					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48134543	48134543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48134543C>T	ENST00000405493.2	-	21	2196	c.1987G>A	c.(1987-1989)Gag>Aag	p.E663K	RAPGEF3_ENST00000548919.1_Missense_Mutation_p.E614K|RAPGEF3_ENST00000449771.2_Missense_Mutation_p.E705K|RP1-197B17.3_ENST00000547799.1_lincRNA|RAPGEF3_ENST00000549151.1_Missense_Mutation_p.E663K|RAPGEF3_ENST00000389212.3_Missense_Mutation_p.E705K|RAPGEF3_ENST00000171000.4_Missense_Mutation_p.E663K	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	663					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		ATGAAGCGCTCCAGGTTGGCG	0.657000													18	57					0	0	1	0	0
MPZL2	10205	broad.mit.edu	37	11	118134847	118134847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118134847G>A	ENST00000278937.2	-	1	150	c.22C>T	c.(22-24)Cgt>Tgt	p.R8C	MPZL2_ENST00000525647.1_5'UTR|MPZL2_ENST00000438295.2_Missense_Mutation_p.R8C	NM_005797.3	NP_005788.1	O60487	MPZL2_HUMAN	myelin protein zero-like 2	8					anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|skin(1)	11	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		AGCACCGCACGAGTAGAGCTC	0.577000													6	71					0	0	1	0	0
NOX4	50507	broad.mit.edu	37	11	89166025	89166025	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:89166025C>T	ENST00000535633.1	-	7	714		c.e7-1		NOX4_ENST00000534731.1_Splice_Site|NOX4_ENST00000527956.1_Splice_Site|NOX4_ENST00000424319.1_Splice_Site|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000263317.4_Splice_Site|NOX4_ENST00000542487.1_Splice_Site|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000528341.1_Splice_Site|NOX4_ENST00000527626.1_Splice_Site|NOX4_ENST00000525196.1_Splice_Site|NOX4_ENST00000343727.5_Splice_Site|NOX4_ENST00000532825.1_Splice_Site|NOX4_ENST00000413594.2_Splice_Site	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AGGCCAGGAACTATAAAAATG	0.353000													7	36					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891236	18891236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18891236G>A	ENST00000317658.3	+	1	192	c.34G>A	c.(34-36)Gaa>Aaa	p.E12K		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	12					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				GAAGGACAAGGAAAGAGTAAT	0.423000													8	91					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101892274	101892274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101892274C>T	ENST00000360264.3	+	24	4523	c.4503C>T	c.(4501-4503)cgC>cgT	p.R1501R	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292535.7_Silent_p.R1490R|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000556210.1_Silent_p.R1332R|CUX1_ENST00000550008.2_Silent_p.R1434R|CUX1_ENST00000549414.2_Silent_p.R1468R|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Silent_p.R1388R	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	1490					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCATCCACCGCCTGGAGAAGG	0.706000													5	14					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965258	88965258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:88965258G>A	ENST00000333190.4	+	4	3571	c.2962G>A	c.(2962-2964)Gag>Aag	p.E988K		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	988						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTATGCAAGTGAGAGCAGAAA	0.398000										HNSCC(36;0.09)			38	71					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182347137	182347137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182347137G>A	ENST00000397033.2	+	8	1321	c.891G>A	c.(889-891)atG>atA	p.M297I		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	297					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TACATGAAATGAAAGGTAAAA	0.313000													26	74					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33507692	33507692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33507692G>A	ENST00000268876.5	+	18	2473	c.2376G>A	c.(2374-2376)aaG>aaA	p.K792K	UNC45B_ENST00000433649.1_Silent_p.K790K|UNC45B_ENST00000591048.1_Silent_p.K711K|UNC45B_ENST00000378449.1_Silent_p.K711K|UNC45B_ENST00000394570.2_Silent_p.K790K	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	792					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				TGCTCCACAAGGAGGTGAGGC	0.602000													11	23					0	0	1	0	0
GOLGA2P5	55592	broad.mit.edu	37	12	100550758	100550758	+	RNA	SNP	G	G	A	rs150859784	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100550758G>A	ENST00000397112.4	-	0	2063					NR_036632.1															large_intestine(1)|lung(3)	4						TCATCAGCAGGGTTCTGGGCA	0.632000													15	49					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043327	117043327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117043327G>A	ENST00000371876.1	-	4	3571	c.1150C>T	c.(1150-1152)Cac>Tac	p.H384Y	KLHL13_ENST00000262820.3_Missense_Mutation_p.H435Y|KLHL13_ENST00000371878.1_Missense_Mutation_p.H384Y|KLHL13_ENST00000371882.1_Missense_Mutation_p.H384Y|KLHL13_ENST00000541812.1_Missense_Mutation_p.H419Y|KLHL13_ENST00000545703.1_Missense_Mutation_p.H393Y|KLHL13_ENST00000469946.1_Missense_Mutation_p.H384Y|KLHL13_ENST00000539496.1_Missense_Mutation_p.H438Y|KLHL13_ENST00000540167.1_Missense_Mutation_p.H419Y			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	435					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GCACTTAGGTGGAAGAAGGTG	0.398000													18	16					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029801	150029801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150029801C>T	ENST00000394243.1	+	3	3070	c.2696C>T	c.(2695-2697)tCt>tTt	p.S899F	SYNPO_ENST00000519664.1_Missense_Mutation_p.S655F|SYNPO_ENST00000522122.1_Missense_Mutation_p.S899F|SYNPO_ENST00000307662.4_Missense_Mutation_p.S655F	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	899	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGGCGTGGTCTCCCCGAGCC	0.667000													37	124					0	0	1	0	0
TRAV2	28691	broad.mit.edu	37	14	22180969	22180969	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22180969G>A	ENST00000390424.2	+	0	251																											TTCTCAGCAGGGACGATACAA	0.502000													73	192					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55307294	55307294	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55307294G>A	ENST00000358193.3	+	10	1244	c.1190G>A	c.(1189-1191)aGg>aAg	p.R397K	C1orf177_ENST00000371273.3_Intron	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	397										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CTTAGAATCAGGCTGTTTTgt	0.428000													29	77					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39331857	39331857	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39331857C>T	ENST00000263408.4	-	5	631	c.536G>A	c.(535-537)gGa>gAa	p.G179E	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	179	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GTTACAGAGTCCATTGTAGAA	0.438000													48	147					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38858489	38858489	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38858489G>A	ENST00000359357.3	+	56	8138	c.7884G>A	c.(7882-7884)atG>atA	p.M2628I	DNAH8_ENST00000441566.1_Missense_Mutation_p.M2592I|DNAH8_ENST00000449981.2_Missense_Mutation_p.M2845I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TATGTGAGATGATTGTGAATT	0.358000													43	97					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179604982	179604982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179604982G>A	ENST00000444136.1	+	9	1730	c.1480G>A	c.(1480-1482)Gat>Aat	p.D494N	TDRD5_ENST00000367614.1_Missense_Mutation_p.D494N|TDRD5_ENST00000294848.8_Missense_Mutation_p.D494N	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	494					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CTATAGCAGGGATTCGTCAGA	0.408000													30	57					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50464087	50464087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:50464087C>T	ENST00000404971.1	-	19	4845	c.3506G>A	c.(3505-3507)aGc>aAc	p.S1169N	NRXN1_ENST00000342183.5_Missense_Mutation_p.S94N|NRXN1_ENST00000402717.3_Missense_Mutation_p.S1121N|NRXN1_ENST00000401669.2_Missense_Mutation_p.S1129N|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401710.1_Missense_Mutation_p.S147N|NRXN1_ENST00000406316.2_Missense_Mutation_p.S1129N|NRXN1_ENST00000405472.3_Missense_Mutation_p.S1121N|NRXN1_ENST00000406859.3_Missense_Mutation_p.S1129N	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1129	Laminin G-like 6.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.S94I(1)|p.S1170I(1)|p.S1129I(1)|p.S1169I(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACCACCTTTGCTAAAGATATA	0.413000													35	76					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686769	54686769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54686769C>T	ENST00000540264.2	-	2	1020	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	NFE2_ENST00000312156.4_Missense_Mutation_p.E171K|NFE2_ENST00000435572.2_Missense_Mutation_p.E171K|RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000553070.1_Missense_Mutation_p.E171K			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	171	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						TCTACATATTCGCTGCGCCGC	0.562000													16	104					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6833264	6833264	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6833264C>T	ENST00000304076.2	+	16	1672	c.1578C>T	c.(1576-1578)acC>acT	p.T526T	VAV1_ENST00000596764.1_Silent_p.T494T|VAV1_ENST00000539284.1_Silent_p.T429T|VAV1_ENST00000599806.1_Silent_p.T471T|VAV1_ENST00000602142.1_Silent_p.T526T	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	526					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						TTGAGGAGACCACATCCTGCA	0.498000													8	50					0	0	1	0	0
TMCO1	54499	broad.mit.edu	37	1	165697266	165697266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165697266G>A	ENST00000367881.5	-	7	989	c.714C>T	c.(712-714)ttC>ttT	p.F238F	TMCO1_ENST00000464650.1_Silent_p.F103F|TMCO1_ENST00000392129.6_Silent_p.F187F|TMCO1_ENST00000580248.1_Silent_p.F103F			Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	187						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GAGTTCAAGAGAACTTCCCAG	0.473000													28	90					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535791	69535791	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69535791C>T	ENST00000338206.5	-	1	555	c.546G>A	c.(544-546)gaG>gaA	p.E182E		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	182					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CACCATTCTTCTCAAATGTGT	0.398000													86	214					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220156210	220156210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220156210G>A	ENST00000295718.2	-	20	2951	c.2711C>T	c.(2710-2712)cCc>cTc	p.P904L	PTPRN_ENST00000497977.1_5'UTR|PTPRN_ENST00000409251.3_Missense_Mutation_p.P875L|PTPRN_ENST00000423636.2_Missense_Mutation_p.P814L	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	904	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CACGATGATGGGGCAGGAGCG	0.592000													14	39					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201185871	201185871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201185871G>A	ENST00000335211.4	+	16	9715	c.9585G>A	c.(9583-9585)gtG>gtA	p.V3195V	IGFN1_ENST00000295591.8_Silent_p.V355V	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGATATTGGTGGCTCCTGAGG	0.652000													20	53					0	0	1	0	0
GOLT1A	127845	broad.mit.edu	37	1	204172074	204172074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204172074G>A	ENST00000308302.3	-	2	252	c.67C>T	c.(67-69)Ctc>Ttc	p.L23F		NM_198447.1	NP_940849.1	Q6ZVE7	GOT1A_HUMAN	golgi transport 1A	23					protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane				kidney(1)|lung(2)|urinary_tract(1)	4	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			GTTCCAAAGAGGATGAAGAAG	0.567000													18	51					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56400068	56400068	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56400068G>A	ENST00000355701.3	-	9	2134	c.1264C>T	c.(1264-1266)Cgc>Tgc	p.R422C	BZRAP1_ENST00000268893.6_Missense_Mutation_p.R362C|BZRAP1_ENST00000343736.4_Missense_Mutation_p.R422C	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	422						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGGCTCTTGCGAAGGGCTGAG	0.657000													21	48					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94696948	94696948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94696948G>A	ENST00000304338.3	+	4	473	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K	PPP4R4_ENST00000555690.1_3'UTR	NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	107						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TGCAGGAGTGGAAATGCAGTT	0.393000													18	68					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103557528	103557528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103557528C>T	ENST00000424685.2	-	2	490	c.331G>A	c.(331-333)Gga>Aga	p.G111R	RELN_ENST00000343529.5_Missense_Mutation_p.G111R|RELN_ENST00000428762.1_Missense_Mutation_p.G111R			P78509	RELN_HUMAN	reelin	111	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.G111R(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTACCAAATCCGAAAGCACTG	0.388000													39	98					0	0	1	0	0
DIEXF	27042	broad.mit.edu	37	1	210001478	210001478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210001478C>T	ENST00000491415.2	+	1	127	c.70C>T	c.(70-72)Ctt>Ttt	p.L24F		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	24					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						GAAGAAACATCTTCGAGATTT	0.547000											OREG0014221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	61					0	0	1	0	0
TUBB3	10381	broad.mit.edu	37	16	90001895	90001895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:90001895C>T	ENST00000304984.5	+	3	3115	c.820C>T	c.(820-822)Ccc>Tcc	p.P274S	TUBB3_ENST00000555576.1_Intron|TUBB3_ENST00000556922.1_Missense_Mutation_p.P693S|TUBB3_ENST00000554444.1_Missense_Mutation_p.P274S|TUBB3_ENST00000315491.7_Missense_Mutation_p.P346S			Q13509	TBB3_HUMAN	tubulin, beta 3 class III	346					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGAGTGGATCCCCAACAACGT	0.612000													51	177					0	0	1	0	0
TIPARP	25976	broad.mit.edu	37	3	156395585	156395585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:156395585C>T	ENST00000461166.1	+	2	687	c.99C>T	c.(97-99)atC>atT	p.I33I	TIPARP_ENST00000486483.1_Silent_p.I33I|TIPARP_ENST00000295924.7_Silent_p.I33I|TIPARP_ENST00000542783.1_Silent_p.I33I	NM_001184717.1	NP_001171646.1	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	33							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CTGAGAAGATCACTCCATTGA	0.433000													20	147					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148921717	148921717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148921717C>T	ENST00000262085.3	+	8	2099	c.1994C>T	c.(1993-1995)cCg>cTg	p.P665L	ZNF282_ENST00000479907.1_3'UTR	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	665					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CGGCAGCTCCCGCCGCCTCCT	0.736000													4	10					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688457	60688457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:60688457C>T	ENST00000335712.6	-	4	1817	c.1590G>A	c.(1588-1590)cgG>cgA	p.R530R	BCL11A_ENST00000538214.1_Silent_p.R496R|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000356842.4_Silent_p.R530R|BCL11A_ENST00000537768.1_Silent_p.R199R|BCL11A_ENST00000358510.4_Silent_p.R496R	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	530					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CGACCGCGCCCCGCGAGCTGT	0.697000			T	IGH@	B-CLL								6	12					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29598859	29598859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29598859G>A	ENST00000431530.3	+	1	112	c.54G>A	c.(52-54)aaG>aaA	p.K18K		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	8						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TGGCTCCTAAGAAATCATGTT	0.448000													22	90					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43683251	43683251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43683251C>T	ENST00000599812.1	-	3	584	c.489G>A	c.(487-489)gaG>gaA	p.E163E	PSG5_ENST00000407356.1_Intron|PSG5_ENST00000404580.1_Intron|PSG5_ENST00000342951.6_Intron|PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407568.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	163	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				AGATCACAGCCTCCATGGCCT	0.527000													81	272					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100354555	100354555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100354555C>T	ENST00000273352.3	+	5	750	c.482C>T	c.(481-483)tCt>tTt	p.S161F	GPR128_ENST00000475887.1_5'UTR	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	161					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.S161F(1)		NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						AATAACATTTCTTCTGAAGTC	0.368000													18	88					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281892	49281892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:49281892G>A	ENST00000282018.3	+	1	942	c.939G>A	c.(937-939)aaG>aaA	p.K313K		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	313					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	AGAATTTTAAGGACAGACTAA	0.443000													34	67					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4833673	4833673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4833673C>T	ENST00000268231.8	-	6	870	c.607G>A	c.(607-609)Gag>Aag	p.E203K	SEPT12_ENST00000396693.5_Missense_Mutation_p.E157K	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	203					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						GCCTCTCGCTCCTCCATGGTC	0.687000													26	46					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237753151	237753151	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237753151G>A	ENST00000366574.2	+	30	3974	c.3657G>A	c.(3655-3657)aaG>aaA	p.K1219K	RYR2_ENST00000542537.1_Silent_p.K1203K|RYR2_ENST00000360064.6_Silent_p.K1217K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1219	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACTTTGGAAAGGATGTCAGCA	0.408000													14	45					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31374318	31374318	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31374318G>T	ENST00000328111.2	+	5	638	c.317G>T	c.(316-318)cGa>cTa	p.R106L	DNMT3B_ENST00000443239.3_Intron|DNMT3B_ENST00000201963.3_Missense_Mutation_p.R118L|DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000348286.2_Missense_Mutation_p.R106L|DNMT3B_ENST00000344505.4_Missense_Mutation_p.R106L|DNMT3B_ENST00000353855.2_Missense_Mutation_p.R106L|DNMT3B_ENST00000375623.4_Intron	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	106	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTCCGAACTCGAAATAACAAC	0.632000													18	54					1.87028e-06	1.87439e-06	1	1	0
USP11	8237	broad.mit.edu	37	X	47100963	47100963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:47100963C>T	ENST00000377107.2	+	9	1398	c.1044C>T	c.(1042-1044)tcC>tcT	p.S348S	USP11_ENST00000218348.3_Silent_p.S391S			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	391					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						ATTTTGCATCCCAATTTCTGG	0.547000													59	30					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19635037	19635037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19635037G>A	ENST00000235835.3	-	2	419	c.398C>T	c.(397-399)cCc>cTc	p.P133L		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	133					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTCCACTTGGGGACACTGCAG	0.602000													13	72					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143048907	143048907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143048907C>T	ENST00000343257.2	+	23	2903	c.2816C>T	c.(2815-2817)cCt>cTt	p.P939L		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	939					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CCAGAGCCCCCTCTCTCCCTG	0.647000													25	48					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110730466	110730466	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110730466C>T	ENST00000282356.4	+	5	843	c.445C>T	c.(445-447)Ctg>Ttg	p.L149L	CAMK4_ENST00000512453.1_Silent_p.L149L	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	149	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TAAACAAATCCTGGAGGCAGT	0.398000													30	39					0	0	1	0	0
DEFA6	1671	broad.mit.edu	37	8	6782352	6782352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:6782352G>A	ENST00000297436.2	-	2	331	c.291C>T	c.(289-291)ttC>ttT	p.F97F		NM_001926.3	NP_001917.1	Q01524	DEF6_HUMAN	defensin, alpha 6, Paneth cell-specific	97					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				lung(4)	4			STAD - Stomach adenocarcinoma(24;0.0322)	COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		AGAGGCAGCAGAATCTGTGGT	0.418000													7	82					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491720	100491720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100491720C>T	ENST00000302913.4	-	2	272	c.134G>A	c.(133-135)gGg>gAg	p.G45E	ACHE_ENST00000428317.1_Missense_Mutation_p.G45E|ACHE_ENST00000412389.1_Missense_Mutation_p.G45E|ACHE_ENST00000411582.1_Missense_Mutation_p.G45E|ACHE_ENST00000241069.5_Missense_Mutation_p.G45E|ACHE_ENST00000419336.2_Missense_Mutation_p.G45E	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	45					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CAGCCGGCCCCCACGCACCGT	0.692000													3	15					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81239646	81239646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81239646C>T	ENST00000552864.1	-	4	548	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	116	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						CCAAGGCCTTCATCAGTCTTT	0.458000													28	47					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159166837	159166837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159166837C>T	ENST00000368125.4	+	7	1096	c.939C>T	c.(937-939)acC>acT	p.T313T	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000497636.1_3'UTR|CADM3_ENST00000368124.4_Silent_p.T347T	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	313	Ig-like C2-type 2.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					CCTACTACACCCTCAATGTTA	0.488000													27	73					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108214637	108214637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108214637G>A	ENST00000273353.3	-	8	817	c.761C>T	c.(760-762)tCc>tTc	p.S254F		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	254	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AAAACGAGAGGAGTTGTCATT	0.338000													7	26					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95608714	95608714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95608714G>A	ENST00000395505.2	-	3	2339	c.2247C>T	c.(2245-2247)ttC>ttT	p.F749F	ZNF484_ENST00000332591.6_Silent_p.F749F|ZNF484_ENST00000375495.3_Silent_p.F785F|ZNF484_ENST00000395506.3_Silent_p.F787F|ANKRD19P_ENST00000473204.1_RNA	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	785					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						ATCTGATGGTGAAGGCCTTTC	0.398000													69	141					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585738	179585738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179585738C>T	ENST00000589042.1	-	79	23232	c.23008G>A	c.(23008-23010)Gaa>Aaa	p.E7670K	TTN_ENST00000342992.6_Missense_Mutation_p.E6426K|TTN_ENST00000591111.1_Missense_Mutation_p.E7353K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7353	Ig-like 59.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACTAGCTTCATTGATCGTA	0.433000													32	78					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109318451	109318451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109318451C>T	ENST00000356711.2	+	2	306	c.180C>T	c.(178-180)ctC>ctT	p.L60L	MYO16_ENST00000357550.2_Silent_p.L60L|MYO16_ENST00000251041.5_Silent_p.L60L	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	60					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACTTCAACCTCACGGACATGC	0.433000													8	24					0	0	1	0	0
FSCN2	25794	broad.mit.edu	37	17	79495959	79495959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79495959C>T	ENST00000417245.2	+	1	538	c.402C>T	c.(400-402)caC>caT	p.H134H	FSCN2_ENST00000334850.7_Silent_p.H134H	NM_001077182.2|NM_012418.3	NP_001070650.1|NP_036550.1	O14926	FSCN2_HUMAN	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	134					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging			endometrium(1)|lung(1)|prostate(1)|urinary_tract(1)	4	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GGACCGTGCACCTGGCCATCC	0.711000													3	8					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73434899	73434899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73434899G>A	ENST00000224721.6	+	14	1500	c.1495G>A	c.(1495-1497)Gaa>Aaa	p.E499K	CDH23_ENST00000299366.7_Missense_Mutation_p.E539K	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	494	Cadherin 5.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CACCTTTGGGGAAGTCAGCTA	0.572000													10	34					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202593359	202593359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202593359G>A	ENST00000264276.6	-	15	3089	c.2717C>T	c.(2716-2718)tCc>tTc	p.S906F	ALS2_ENST00000457679.2_Missense_Mutation_p.S218F	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	906	PH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						CTTCCTCAAGGAATCCTGGAA	0.383000													24	54					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890533	23890533	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23890533G>C	ENST00000532292.1	-	1	642	c.548C>G	c.(547-549)tCc>tGc	p.S183C		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GACACTTGAGGAGGGAGCAAA	0.587000													5	56					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152325619	152325619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152325619C>T	ENST00000388718.5	-	3	4715	c.4643G>A	c.(4642-4644)gGa>gAa	p.G1548E	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1548							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGGTATCTCCTGTCTGTCC	0.473000													72	368					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123244952	123244952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123244952C>T	ENST00000358487.5	-	16	2424	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	FGFR2_ENST00000360144.3_Missense_Mutation_p.E630K|FGFR2_ENST00000478859.1_Missense_Mutation_p.E490K|FGFR2_ENST00000369059.1_Missense_Mutation_p.E604K|FGFR2_ENST00000351936.6_Missense_Mutation_p.E716K|FGFR2_ENST00000357555.5_Missense_Mutation_p.E629K|FGFR2_ENST00000369060.4_Missense_Mutation_p.E602K|FGFR2_ENST00000346997.2_Missense_Mutation_p.E716K|FGFR2_ENST00000356226.4_Missense_Mutation_p.E601K|FGFR2_ENST00000457416.2_Missense_Mutation_p.E719K|FGFR2_ENST00000369061.4_Missense_Mutation_p.E606K|FGFR2_ENST00000369056.1_Missense_Mutation_p.E719K	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	718	Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CTGTGTCCTTCCTTCAGCAGC	0.537000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				50	118					0	0	1	0	0
AADACL2	344752	broad.mit.edu	37	3	151474779	151474779	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151474779G>A	ENST00000356517.3	+	5	712		c.e5-1		RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2							extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TATATTTTCAGGTGCAGAATG	0.303000													26	52					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168621	142168621	+	RNA	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142168621T>A	ENST00000454561.2	-	0	302																											CTTGCTGTCCTCTCGTTTTGA	0.547000													20	84					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547747	63547747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:63547747G>A	ENST00000397968.2	+	12	2401	c.1975G>A	c.(1975-1977)Gga>Aga	p.G659R	CDH7_ENST00000323011.3_Missense_Mutation_p.G659R	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	659					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				CGAGGGCGGGGGAGAGGAGGA	0.478000													23	70					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55939061	55939061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55939061G>A	ENST00000244728.5	-	20	2331	c.1934C>T	c.(1933-1935)tCa>tTa	p.S645L	COL21A1_ENST00000535941.1_Missense_Mutation_p.S645L|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.S45L|COL21A1_ENST00000370819.1_Missense_Mutation_p.S642L	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	645	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTGGCCTGGTGAGCCATTGCT	0.333000													20	112					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149453010	149453010	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149453010C>T	ENST00000286301.3	-	7	1227	c.936G>A	c.(934-936)gaG>gaA	p.E312E	CSF1R_ENST00000543093.1_Intron	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	312	Ig-like C2-type 4.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CCACGGTCACCTCCTGGATGA	0.532000													44	116					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130509442	130509442	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130509442G>A	ENST00000314830.8	-	6	1361	c.1248C>T	c.(1246-1248)tcC>tcT	p.S416S	SH2D3C_ENST00000420366.1_Silent_p.S258S|SH2D3C_ENST00000373274.3_Silent_p.S256S|SH2D3C_ENST00000373276.3_Silent_p.S348S|SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Silent_p.S259S|SH2D3C_ENST00000429553.1_Silent_p.S62S	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	416					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGTAGGCAGGGGAGCTAGGGC	0.597000													16	88					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588598	247588598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247588598C>T	ENST00000366497.2	+	4	2633	c.1853C>T	c.(1852-1854)gCt>gTt	p.A618V	NLRP3_ENST00000391828.3_Missense_Mutation_p.A618V|NLRP3_ENST00000336119.3_Missense_Mutation_p.A618V|NLRP3_ENST00000391827.2_Missense_Mutation_p.A618V|NLRP3_ENST00000348069.2_Missense_Mutation_p.A618V|NLRP3_ENST00000366496.2_Missense_Mutation_p.A618V|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	618					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding	p.A618V(1)		NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AAAGCCAAAGCTAAAAAGCTG	0.483000													16	51					0	0	1	0	0
C9orf152	401546	broad.mit.edu	37	9	112963360	112963360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112963360G>A	ENST00000400613.4	-	2	1197	c.588C>T	c.(586-588)ttC>ttT	p.F196F	C9orf152_ENST00000473442.1_Intron	NM_001012993.2	NP_001013011.2	Q5JTZ5	CI152_HUMAN	chromosome 9 open reading frame 152	196										NS(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						ATTGAGTGCTGAATTTTAAGC	0.502000													12	85					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92102845	92102845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92102845G>A	ENST00000256343.3	-	17	1822	c.1666C>T	c.(1666-1668)Cct>Tct	p.P556S		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	556					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TCGTTCTCAGGTACATATGCA	0.413000													15	76					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157959797	157959797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157959797G>A	ENST00000389413.3	-	6	839	c.736C>T	c.(736-738)Ctc>Ttc	p.L246F	PTPRN2_ENST00000409483.1_Missense_Mutation_p.L208F|PTPRN2_ENST00000404321.2_Missense_Mutation_p.L269F|PTPRN2_ENST00000389416.4_Missense_Mutation_p.L229F|PTPRN2_ENST00000389418.4_Missense_Mutation_p.L246F	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	246						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TAGGCACTGAGGGCCGCCATC	0.667000													5	29					0	0	1	0	0
ZNF850	342892	broad.mit.edu	37	19	37240729	37240729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37240729G>A	ENST00000591344.1	-	5	1371	c.1213C>T	c.(1213-1215)Cgc>Tgc	p.R405C	ZNF850_ENST00000589390.1_Intron	NM_001193552.1|NM_001267779.1	NP_001180481.1|NP_001254708.1	A8MQ14	ZN850_HUMAN	zinc finger protein 850	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										AACCCTGAGCGAAAAGTAAAA	0.383000													9	9					0	0	1	0	0
INPP5J	27124	broad.mit.edu	37	22	31524554	31524554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31524554C>T	ENST00000331075.5	+	9	2156	c.2107C>T	c.(2107-2109)Ctc>Ttc	p.L703F	INPP5J_ENST00000400294.2_Missense_Mutation_p.L336F|INPP5J_ENST00000402238.1_Missense_Mutation_p.L68F|INPP5J_ENST00000401755.1_Missense_Mutation_p.L68F|INPP5J_ENST00000412277.2_Missense_Mutation_p.L636F|INPP5J_ENST00000405300.1_Missense_Mutation_p.L336F|INPP5J_ENST00000404453.1_Missense_Mutation_p.L68F|INPP5J_ENST00000404390.3_Missense_Mutation_p.L335F			Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J	703	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	12						GAGCCACCGACTCCAGGTGAC	0.607000													27	53					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102707	22102707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22102707G>A	ENST00000542433.1	-	1	389	c.292C>T	c.(292-294)Ccg>Tcg	p.P98S		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CCACCAAACGGGATAGCCTTG	0.498000													20	36					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125555862	125555862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125555862C>T	ENST00000431078.1	+	19	3543	c.3179C>T	c.(3178-3180)tCt>tTt	p.S1060F		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1060	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		AATTCTTCTTCTCAGGACTTC	0.498000													7	49					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72937552	72937552	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72937552G>A	ENST00000328801.4	+	2	138	c.138G>A	c.(136-138)aaG>aaA	p.K46K		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	46						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CCCCGGAGAAGGAGAACCGAG	0.642000													6	15					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154067584	154067584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154067584C>T	ENST00000368559.3	-	15	2085	c.2014G>A	c.(2014-2016)Gaa>Aaa	p.E672K	NUP210L_ENST00000271854.3_Missense_Mutation_p.E672K	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	672						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AATACCATTTCCTTCACAGAC	0.408000													21	40					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66204583	66204583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:66204583C>T	ENST00000503581.1	-	4	1258	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	EYS_ENST00000393380.2_Missense_Mutation_p.E241K|EYS_ENST00000370616.2_Missense_Mutation_p.E241K|EYS_ENST00000370618.3_Missense_Mutation_p.E241K|EYS_ENST00000370621.3_Missense_Mutation_p.E241K|EYS_ENST00000342421.5_Missense_Mutation_p.E241K	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	241	EGF-like 2.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CAGACACATTCATATGCTTGC	0.299000													5	9					0	0	1	0	0
GDF11	10220	broad.mit.edu	37	12	56137461	56137461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56137461G>A	ENST00000257868.5	+	1	398	c.361G>A	c.(361-363)Ggc>Agc	p.G121S		NM_005811.3	NP_005802.1	O95390	GDF11_HUMAN	growth differentiation factor 11	121					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|urinary_tract(1)	12						CGACTTCCAGGGCGACGCGCT	0.667000													16	19					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189868140	189868140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189868140C>T	ENST00000304636.3	+	37	2727	c.2557C>T	c.(2557-2559)Cct>Tct	p.P853S	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	853	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CATATAGGGTCCTCCTGGTCC	0.383000													14	43					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508103	37508103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37508103G>A	ENST00000374660.1	+	40	3751	c.3652G>A	c.(3652-3654)Gaa>Aaa	p.E1218K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1099K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1099K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1170						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ACTGAAAGAGGAATCATTAAC	0.338000													69	167					0	0	1	0	0
ASZ1	136991	broad.mit.edu	37	7	117021086	117021086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117021086C>T	ENST00000284629.2	-	9	986	c.924G>A	c.(922-924)atG>atA	p.M308I		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	308	SAM.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CATCTTCCCTCATGGTCAAAA	0.308000													48	240					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158627485	158627485	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158627485C>T	ENST00000368148.3	-	19	2768		c.e19-1		SPTA1_ENST00000368147.3_Splice_Site	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GCAAAGTGTCCTATGGAGTAA	0.413000													31	88					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38516566	38516566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38516566G>A	ENST00000356264.2	-	6	615	c.400C>T	c.(400-402)Cgc>Tgc	p.R134C	AMPH_ENST00000428293.2_Missense_Mutation_p.R134C|AMPH_ENST00000325590.5_Missense_Mutation_p.R134C	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	134	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						TTGGCGATGCGATTCTGTCAA	0.522000													19	60					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17943349	17943349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17943349G>A	ENST00000458235.1	-	19	2758	c.2659C>T	c.(2659-2661)Cgt>Tgt	p.R887C	JAK3_ENST00000534444.1_Missense_Mutation_p.R887C|JAK3_ENST00000527670.1_Missense_Mutation_p.R887C	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	887	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.R887C(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						CTGACACCACGATACTTGACA	0.547000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								21	108					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38991718	38991718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38991718C>T	ENST00000302328.3	-	1	334	c.136G>A	c.(136-138)Gaa>Aaa	p.E46K	SCN11A_ENST00000456224.3_Missense_Mutation_p.E46K|SCN11A_ENST00000444237.2_Missense_Mutation_p.E46K|SCN11A_ENST00000450244.1_Missense_Mutation_p.E46K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	46					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGGGGTACTTCTCCTGTCTGG	0.527000													85	143					0	0	1	0	0
PAOX	196743	broad.mit.edu	37	10	135197711	135197711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:135197711C>T	ENST00000278060.5	+	4	1199	c.1116C>T	c.(1114-1116)gcC>gcT	p.A372A	PAOX_ENST00000368539.4_3'UTR|PAOX_ENST00000480071.2_Intron|PAOX_ENST00000357296.3_Silent_p.A372A|PAOX_ENST00000368535.2_3'UTR	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	510					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TCCTGCCTGCCTTTGCGTACG	0.587000													39	95					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102645	22102645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22102645G>A	ENST00000542433.1	-	1	451	c.354C>T	c.(352-354)ttC>ttT	p.F118F		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AGGTGTAGAGGAAGCACTGGG	0.502000													10	22					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112969698	112969698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112969698C>T	ENST00000485230.1	+	4	1019	c.394C>T	c.(394-396)Cct>Tct	p.P132S	BOC_ENST00000355385.3_Intron|BOC_ENST00000495514.1_Intron|BOC_ENST00000273395.4_Intron|BOC_ENST00000484034.1_Missense_Mutation_p.P132S			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	834	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			TGCTCCTTTGCCTCCCTGCCA	0.602000													11	21					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19136816	19136816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19136816G>A	ENST00000601879.1	-	3	638	c.341C>T	c.(340-342)tCt>tTt	p.S114F	SUGP2_ENST00000598202.1_5'UTR|SUGP2_ENST00000600377.1_Missense_Mutation_p.S128F|SUGP2_ENST00000456085.2_Missense_Mutation_p.L16F|SUGP2_ENST00000452918.2_Missense_Mutation_p.S114F|SUGP2_ENST00000337018.6_Missense_Mutation_p.S114F			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	114					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						ATCAGAGTGAGAAAATTCCAG	0.502000													44	73					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540322	133540322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133540322G>A	ENST00000409261.1	-	14	4435	c.4062C>T	c.(4060-4062)agC>agT	p.S1354S	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Silent_p.S1354S	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1354							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						AGCTGCCTGAGCTCCCCAGGG	0.617000													14	31					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233769	21233769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21233769C>T	ENST00000233242.1	-	26	6098	c.5971G>A	c.(5971-5973)Gaa>Aaa	p.E1991K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1991					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGCTGTATTCATTGTTGTTA	0.463000													31	95					0	0	1	0	0
FAM3B	54097	broad.mit.edu	37	21	42694776	42694776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42694776G>A	ENST00000398646.3	+	1	30	c.15G>A	c.(13-15)agG>agA	p.R5R	FAM3B_ENST00000398652.3_Intron|FAM3B_ENST00000479810.2_Intron|FAM3B_ENST00000357985.2_Intron|FAM3B_ENST00000398647.3_Intron			P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	0					apoptosis|insulin secretion	extracellular space	cytokine activity			central_nervous_system(2)|endometrium(1)|lung(2)	5		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				AAAGCCACAGGGGGGATGGGG	0.647000													12	17					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5457844	5457844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:5457844C>T	ENST00000296564.7	+	12	1313	c.1091C>T	c.(1090-1092)tCa>tTa	p.S364L		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	364	Pro-rich.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						TTACCGTCTTCATTTGCACCT	0.463000													80	250					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299400	58299400	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58299400G>A	ENST00000377918.3	+	4	3478	c.3452G>A	c.(3451-3453)gGa>gAa	p.G1151E		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1151					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GACTGCCGGGGAAACGACCCT	0.448000													14	157					0	0	1	0	0
CHAMP1	283489	broad.mit.edu	37	13	115090016	115090016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:115090016C>T	ENST00000361283.1	+	3	1008	c.699C>T	c.(697-699)ttC>ttT	p.F233F		NM_001164144.1|NM_001164145.1|NM_032436.2	NP_001157616.1|NP_001157617.1|NP_115812.1	Q96JM3	ZN828_HUMAN	chromosome alignment maintaining phosphoprotein 1	233	Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding										AGTCTCATTTCCCGGAAACAT	0.532000													9	156					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947048	237947048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237947048G>A	ENST00000366574.2	+	90	12353	c.12036G>A	c.(12034-12036)atG>atA	p.M4012I	RYR2_ENST00000542537.1_Missense_Mutation_p.M3996I|RYR2_ENST00000360064.6_Missense_Mutation_p.M4018I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4012					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGTGGAGATGATTCTCAAAT	0.383000													6	21					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12939536	12939536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12939536G>A	ENST00000393233.2	-	5	725	c.176C>T	c.(175-177)gCt>gTt	p.A59V	RTBDN_ENST00000322912.5_Silent_p.R132R|RTBDN_ENST00000458671.2_Silent_p.R100R|RTBDN_ENST00000589272.1_Silent_p.R132R|CTD-2265O21.3_ENST00000588469.1_RNA|RTBDN_ENST00000592204.1_Silent_p.R110R	NM_001270440.1	NP_001257369.1	Q9BSG5	RTBDN_HUMAN	retbindin	0						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						GCAGGCGGAAGCGACTGCGAA	0.652000													15	88					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36888828	36888828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36888828C>T	ENST00000301807.6	-	15	5012	c.3115G>A	c.(3115-3117)Gaa>Aaa	p.E1039K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E1589K|TRANK1_ENST00000463984.1_5'UTR|TRANK1_ENST00000428977.2_Missense_Mutation_p.E1039K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1589					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ATCTTCCATTCCTTATAAGCC	0.443000													6	28					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7059991	7059991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7059991G>A	ENST00000299481.4	+	2	520	c.174G>A	c.(172-174)ctG>ctA	p.L58L		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	58	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GGGAGGACCTGGCCAATTTGA	0.458000													18	82					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13660436	13660436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13660436G>A	ENST00000404922.3	+	7	2091	c.1972G>A	c.(1972-1974)Gag>Aag	p.E658K	FBLN2_ENST00000535798.1_Missense_Mutation_p.E684K|FBLN2_ENST00000492059.1_Missense_Mutation_p.E658K|FBLN2_ENST00000295760.7_Missense_Mutation_p.E658K	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	658						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGCCCCACAGGAGCCTGCACT	0.602000													6	25					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192950	132192950	+	Missense_Mutation	SNP	G	G	A	rs141998123		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:132192950G>A	ENST00000359827.3	-	2	1465	c.503C>T	c.(502-504)tCa>tTa	p.S168L	PLXNA4_ENST00000423507.2_Missense_Mutation_p.S168L|PLXNA4_ENST00000321063.4_Missense_Mutation_p.S168L|PLXNA4_ENST00000378539.5_Missense_Mutation_p.S168L			Q9HCM2	PLXA4_HUMAN	plexin A4	168	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCCAAAGACTGAGCCGCTCTC	0.542000													21	68					0	0	1	0	0
C8orf86	389649	broad.mit.edu	37	8	38370085	38370085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:38370085G>A	ENST00000437935.2	-	2	338	c.319C>T	c.(319-321)Ccg>Tcg	p.P107S	C8orf86_ENST00000358138.1_Silent_p.L164L			Q6ZUL3	CH086_HUMAN	chromosome 8 open reading frame 86	0										breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						gaggactgcggaggcttgaga	0.537000													7	76					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40076668	40076668	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40076668G>A	ENST00000324616.5	+	8	1096	c.942G>A	c.(940-942)agG>agA	p.R314R	C12orf40_ENST00000398716.1_Silent_p.R237R|C12orf40_ENST00000405531.3_Silent_p.R314R	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	314								p.R314R(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						ATGAGCAAAGGATAAAGAAAA	0.328000													18	56					0	0	1	0	0
SNX1	6642	broad.mit.edu	37	15	64404804	64404804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:64404804C>T	ENST00000353874.4	+	2	228	c.192C>T	c.(190-192)tcC>tcT	p.S64S	SNX1_ENST00000261889.5_Silent_p.S64S|SNX1_ENST00000561026.1_Silent_p.S64S|SNX1_ENST00000560829.1_5'UTR|SNX1_ENST00000559844.1_Silent_p.S64S			Q13596	SNX1_HUMAN	sorting nexin 1	64					cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13						TAACTACATCCCTTCTTCCCA	0.393000													8	124					0	0	1	0	0
OR52N5	390075	broad.mit.edu	37	11	5798909	5798909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5798909C>T	ENST00000317093.2	-	1	988	c.956G>A	c.(955-957)gGt>gAt	p.G319D	TRIM5_ENST00000380027.1_Intron	NM_001001922.2	NP_001001922.2	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N, member 5	319					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(1)|lung(17)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ACCCTTATCACCCTGGAAGAA	0.343000													40	25					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26694976	26694976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26694976C>T	ENST00000529632.2	+	5	1385	c.1189C>T	c.(1189-1191)Cgc>Tgc	p.R397C	SEZ6L_ENST00000360929.3_Missense_Mutation_p.R397C|SEZ6L_ENST00000402979.1_Missense_Mutation_p.R170C|SEZ6L_ENST00000404234.3_Missense_Mutation_p.R397C|SEZ6L_ENST00000343706.4_Missense_Mutation_p.R397C|SEZ6L_ENST00000403121.1_Missense_Mutation_p.R170C|SEZ6L_ENST00000248933.6_Missense_Mutation_p.R397C	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	397	Sushi 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CAACTTTCCCCGCCGGCCTGA	0.582000													20	49					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	62038627	62038627	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:62038627C>T	ENST00000280772.1	-	4	510	c.319G>A	c.(319-321)Gga>Aga	p.G107R	ANK3_ENST00000503366.1_Missense_Mutation_p.G90R|ANK3_ENST00000373827.2_Missense_Mutation_p.G101R	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	107					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCTGTGTTTCCTTTCTGTGAA	0.383000													35	105					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55266508	55266508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55266508C>T	ENST00000275493.2	+	23	2977	c.2800C>T	c.(2800-2802)Cct>Tct	p.P934S	EGFR_ENST00000454757.2_Missense_Mutation_p.P881S|EGFR_ENST00000455089.1_Missense_Mutation_p.P889S|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	934	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGAACGCCTCCCTCAGCCACC	0.542000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			15	58					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29142037	29142037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29142037C>T	ENST00000377167.2	+	1	727	c.625C>T	c.(625-627)Ctc>Ttc	p.L209F		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CATTTTTGTTCTCATACCTCT	0.468000													34	114					0	0	1	0	0
SERPINA11	256394	broad.mit.edu	37	14	94915077	94915077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94915077C>T	ENST00000334708.3	-	2	99	c.35G>A	c.(34-36)gGg>gAg	p.G12E	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	12					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		GGCCAGGATCCCTGTTCCCAG	0.522000													30	91					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39409223	39409223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39409223C>T	ENST00000257408.4	+	1	751	c.654C>T	c.(652-654)ttC>ttT	p.F218F		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	218	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						TAGATATCTTCAATGACTATG	0.393000													41	107					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	13357153	13357153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:13357153C>T	ENST00000276297.4	-	2	837	c.428G>A	c.(427-429)gGa>gAa	p.G143E	DLC1_ENST00000511869.1_Missense_Mutation_p.G143E|DLC1_ENST00000316609.5_Missense_Mutation_p.G143E	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	143					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GGAGCCTGCTCCTTGGATCAT	0.408000													79	149					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55948773	55948773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55948773C>T	ENST00000263923.4	-	28	3987	c.3692G>A	c.(3691-3693)aGc>aAc	p.S1231N	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1231					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACAGGCCGGCTCTTTCGCTT	0.358000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			20	112					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179486330	179486330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179486330C>T	ENST00000589042.1	-	245	45445	c.45221G>A	c.(45220-45222)gGa>gAa	p.G15074E	TTN_ENST00000342992.6_Missense_Mutation_p.G12506E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G13433E|TTN_ENST00000342175.6_Missense_Mutation_p.G6201E|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G6134E|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G6009E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13433	Fibronectin type-III 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATATCTTCCTGTTTCAAT	0.443000													33	72					0	0	1	0	0
SLC30A2	7780	broad.mit.edu	37	1	26365705	26365705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26365705C>T	ENST00000374278.3	-	7	1134	c.918G>A	c.(916-918)gaG>gaA	p.E306E	SLC30A2_ENST00000374276.3_Silent_p.E355E	NM_032513.3	NP_115902.1	Q9BRI3	ZNT2_HUMAN	solute carrier family 30 (zinc transporter), member 2	306					positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity			cervix(1)|endometrium(2)|kidney(1)|lung(8)|stomach(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		CCGAGTAGTCCTCGATCTGGA	0.612000													4	35					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935849	30935849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30935849G>A	ENST00000355537.3	+	2	1527	c.1380G>A	c.(1378-1380)atG>atA	p.M460I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGCTGCCCATGAAGGAGAAGG	0.642000													15	55					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64603064	64603064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64603064C>T	ENST00000342711.5	-	15	1787	c.1788G>A	c.(1786-1788)ggG>ggA	p.G596G		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	596					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GGGGTCCCATCCCGTTGGTCT	0.667000													20	94					0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132912248	132912248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132912248C>T	ENST00000409867.1	-	4	850	c.601G>A	c.(601-603)Gat>Aat	p.D201N	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like											endometrium(1)|kidney(3)	4						TTAAACTTATCAACTGCATTT	0.308000													3	17					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	91994072	91994072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91994072G>A	ENST00000450295.1	-	16	2912	c.2136C>T	c.(2134-2136)atC>atT	p.I712I	SEMA4D_ENST00000455551.2_Intron|SEMA4D_ENST00000343780.4_Intron|SEMA4D_ENST00000438547.2_Silent_p.I712I|SEMA4D_ENST00000420987.1_Intron|SEMA4D_ENST00000339861.4_Intron|SEMA4D_ENST00000356444.2_Silent_p.I712I|SEMA4D_ENST00000422704.2_Silent_p.I712I			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	712					anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						TGTTGATGACGATCTTTGGTT	0.597000													8	60					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38891888	38891888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38891888C>T	ENST00000359357.3	+	71	10515	c.10261C>T	c.(10261-10263)Cct>Tct	p.P3421S	DNAH8_ENST00000441566.1_Missense_Mutation_p.P3385S|RP1-207H1.3_ENST00000418399.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.P3638S|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACGGAAAATTCCTTTCACAGA	0.363000													7	91					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131976432	131976432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131976432C>T	ENST00000356920.5	+	1	551	c.457C>T	c.(457-459)Ccc>Tcc	p.P153S	PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_Missense_Mutation_p.P153S	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	153							ATP binding	p.P153S(2)									GGGTAAAGTCCCCAGAAAGGA	0.572000													36	194					0	0	1	0	0
CD300C	10871	broad.mit.edu	37	17	72540779	72540779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72540779G>A	ENST00000330793.1	-	2	729	c.369C>T	c.(367-369)ccC>ccT	p.P123P		NM_006678.3	NP_006669.1	Q08708	CLM6_HUMAN	CD300c molecule	123	Ig-like V-type.|Pro-rich.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						CCTCGACAATGGGATCATGAA	0.577000													15	53					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26636735	26636735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:26636735G>A	ENST00000381340.3	-	42	6324	c.5908C>T	c.(5908-5910)Ctg>Ttg	p.L1970L		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1970					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					AACAGGCCCAGGCCACCGGTT	0.468000													23	176					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1444083	1444083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:1444083G>A	ENST00000446702.2	+	22	3526	c.2899G>A	c.(2899-2901)Gaa>Aaa	p.E967K	CNTN6_ENST00000539053.1_Missense_Mutation_p.E895K|CNTN6_ENST00000350110.2_Missense_Mutation_p.E967K			Q9UQ52	CNTN6_HUMAN	contactin 6	967	Fibronectin type-III 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GGTTCCATTTGAAGAAGACTA	0.368000													16	73					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77950759	77950759	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77950759G>A	ENST00000393684.3	-	4	661	c.270C>T	c.(268-270)ccC>ccT	p.P90P	ISM2_ENST00000429906.1_Silent_p.P97P|ISM2_ENST00000342219.4_Silent_p.P178P|ISM2_ENST00000493585.1_Silent_p.P178P|ISM2_ENST00000412904.1_Intron			Q6H9L7	ISM2_HUMAN	isthmin 2	178						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						CCTGGGTCCTGGGAGGCGTGG	0.592000													10	105					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176798994	176798994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176798994C>T	ENST00000408923.3	+	15	1807	c.1619C>T	c.(1618-1620)tCc>tTc	p.S540F	RGS14_ENST00000506944.1_3'UTR	NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	540					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGCCCAGCTCCGAGGAGACC	0.632000													35	344					0	0	1	0	0
GSPT2	23708	broad.mit.edu	37	X	51487060	51487060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:51487060C>T	ENST00000340438.4	+	1	580	c.338C>T	c.(337-339)tCc>tTc	p.S113F		NM_018094.4	NP_060564.2	Q8IYD1	ERF3B_HUMAN	G1 to S phase transition 2	113					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Ovarian(276;0.236)					GTGGAACCTTCCCGAGAGGAA	0.572000													7	4					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15262433	15262433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15262433C>T	ENST00000256953.2	-	5	547	c.211G>A	c.(211-213)Gag>Aag	p.E71K	RERG_ENST00000546331.1_Missense_Mutation_p.E52K|RERG_ENST00000538313.1_Missense_Mutation_p.E71K|RERG_ENST00000536465.1_Missense_Mutation_p.E71K	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	71					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						ATGTGCCCCTCCCTCTGAATG	0.463000													84	371					0	0	1	0	0
FAM107A	11170	broad.mit.edu	37	3	58552332	58552332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58552332C>T	ENST00000394481.1	-	5	976	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	FAM107A_ENST00000360997.2_Missense_Mutation_p.E140K|FAM107A_ENST00000474531.1_Missense_Mutation_p.E171K|FAM107A_ENST00000464064.1_3'UTR|FAM107A_ENST00000447756.2_Missense_Mutation_p.E168K	NM_007177.2	NP_009108.1	O95990	F107A_HUMAN	family with sequence similarity 107, member A	140					regulation of cell growth	nucleus	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(55;0.000189)|Kidney(10;0.000536)|KIRC - Kidney renal clear cell carcinoma(10;0.000716)|OV - Ovarian serous cystadenocarcinoma(275;0.154)		TCTCTCTCTTCGCTGGTCAGT	0.602000													10	103					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32891130	32891130	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32891130G>A	ENST00000330048.5	-	0	2925					NR_003083.2																						CAGTCACCATGGAGAGATCAA	0.597000													26	101					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834206	101834206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101834206G>A	ENST00000506729.1	-	1	514	c.343C>T	c.(343-345)Ctg>Ttg	p.L115L	SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000379807.3_Silent_p.L115L|SLCO6A1_ENST00000379810.1_Silent_p.L115L|SLCO6A1_ENST00000389019.3_Silent_p.L115L|SLCO6A1_ENST00000513675.1_Silent_p.L115L			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	115	Cys-rich.					integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CATATGAGCAGGATGCAGTAG	0.572000													21	49					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74536339	74536339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74536339C>T	ENST00000398814.3	+	2	466	c.35C>T	c.(34-36)cCa>cTa	p.P12L	CCDC33_ENST00000321288.5_Intron	NM_025055.3	NP_079331.3	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	215							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						ACTGAAGACCCAGAGGAGCCC	0.557000													20	153					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69472591	69472591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69472591C>T	ENST00000303714.4	+	18	1991	c.1669C>T	c.(1669-1671)Cgc>Tgc	p.R557C		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	557	Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						tcctccctcccgccctcctcc	0.622000									Familial Infantile Hemangioma				7	42					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819707	50819707	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50819707C>T	ENST00000374115.3	+	1	1361	c.921C>T	c.(919-921)ttC>ttT	p.F307F	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	307					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						CCCTCGCCTTCCTCGAACCCA	0.637000													48	77					0	0	1	0	0
SP3	6670	broad.mit.edu	37	2	174783444	174783444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:174783444G>A	ENST00000310015.6	-	5	2239	c.1709C>T	c.(1708-1710)aCc>aTc	p.T570I	SP3_ENST00000418194.2_Missense_Mutation_p.T502I|SP3_ENST00000455789.2_Missense_Mutation_p.T517I	NM_001172712.1|NM_003111.4	NP_001166183.1|NP_003102.1	Q02447	SP3_HUMAN	Sp3 transcription factor	570	Repressor domain.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	NS(2)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TAGGTCATTGGTATTCAAGGT	0.428000													44	113					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56349080	56349080	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56349080G>A	ENST00000340482.3	-	10	2238	c.2062C>T	c.(2062-2064)Cgc>Tgc	p.R688C	MPO_ENST00000225275.3_Missense_Mutation_p.R656C			P05164	PERM_HUMAN	myeloperoxidase	656					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GGGCCCACGCGGCCTTTGCGC	0.632000													13	36					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130845791	130845791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130845791G>A	ENST00000245255.3	+	15	2004	c.1732G>A	c.(1732-1734)Gat>Aat	p.D578N		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	578	Piwi.|RNA-binding (By similarity).				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CCTGTGTACAGATTGCCCTAC	0.433000													21	31					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26586932	26586932	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26586932C>T	ENST00000436318.2	-	2	688	c.555G>A	c.(553-555)gtG>gtA	p.V185V	ANO3_ENST00000537978.1_Intron|MUC15_ENST00000281268.8_Silent_p.V185V|ANO3_ENST00000256737.3_Intron|MUC15_ENST00000527569.1_Silent_p.V185V|MUC15_ENST00000455601.2_Silent_p.V158V|ANO3_ENST00000525139.1_Intron|MUC15_ENST00000529533.1_Silent_p.V185V|ANO3_ENST00000531568.1_Intron			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	158						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						CAGGAGTTTTCACGGTGTCAT	0.448000													49	120					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40944253	40944253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40944253C>T	ENST00000346991.5	+	22	6833	c.6443C>T	c.(6442-6444)aCc>aTc	p.T2148I	CASC5_ENST00000399668.2_Missense_Mutation_p.T2122I			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	2148	Necessary for kinetochore localization and for interaction with NSL1 and DSN1.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		GCTGTATTCACCTTTGTTTAT	0.358000													12	61					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032617	30032617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30032617C>T	ENST00000328224.6	-	2	2842	c.1609G>A	c.(1609-1611)Ggc>Agc	p.G537S		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	537						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						ACAATCTTGCCCCCTACAGTG	0.498000													9	66					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56403666	56403666	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56403666C>T	ENST00000355701.3	-	3	1428	c.558G>A	c.(556-558)acG>acA	p.T186T	BZRAP1-AS1_ENST00000579527.1_RNA|BZRAP1_ENST00000268893.6_Silent_p.T186T|BZRAP1_ENST00000343736.4_Silent_p.T186T	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	186						mitochondrion	benzodiazepine receptor binding	p.T186T(2)		cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCTCAGGTTCGTTTCCTGCA	0.632000													23	51					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113312259	113312259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113312259G>A	ENST00000401783.2	-	2	993	c.657C>T	c.(655-657)ttC>ttT	p.F219F	SVEP1_ENST00000374469.1_Silent_p.F196F|SVEP1_ENST00000374461.1_Silent_p.F196F|SVEP1_ENST00000302728.8_Silent_p.F219F|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	219	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TGCCAAAAGTGAAGATCTCCA	0.458000													13	54					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51370588	51370588	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51370588G>A	ENST00000266037.9	+	35	3538		c.e35-1			NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCCACCAATAGCCTGCTGGAG	0.522000													20	80					0	0	1	0	0
KIAA1328	57536	broad.mit.edu	37	18	34740344	34740344	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:34740344G>A	ENST00000591619.1	+	8	2188	c.1402_splice	c.e8+1	p.G468_splice	KIAA1328_ENST00000435985.2_Splice_Site_p.G224_splice|KIAA1328_ENST00000543923.1_Splice_Site_p.G364_splice|KIAA1328_ENST00000280020.5_Splice_Site_p.G472_splice|KIAA1328_ENST00000586135.1_Splice_Site_p.G224_splice			Q86T90	K1328_HUMAN	KIAA1328	472										central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	14				COAD - Colon adenocarcinoma(74;0.195)		ACCCCAAAGAGGTAAGTTTAA	0.408000													11	39					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869840	4869840	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4869840G>C	ENST00000322101.2	-	1	674	c.599C>G	c.(598-600)gCt>gGt	p.A200G	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCACCCCAAGCTTCTGGGCA	0.532000													32	91					0	0	1	0	0
LINC00842	643650	broad.mit.edu	37	10	47133588	47133588	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:47133588C>T	ENST00000422732.2	-	0	435					NR_033957.1																						gccaccatatccaccaccacc	0.483000													13	98					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185018422	185018422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:185018422C>T	ENST00000296741.2	-	7	1234	c.1093G>A	c.(1093-1095)Ggc>Agc	p.G365S		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	365					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		AGGAAGATGCCCCGCATGTCC	0.592000													15	80					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41137716	41137716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41137716G>A	ENST00000380588.4	+	3	458	c.355G>A	c.(355-357)Ggg>Agg	p.G119R	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	119	Ig-like V-type 1.					integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				CAGTGATTCGGGGAACATCAG	0.542000													15	21					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169780299	169780299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169780299C>T	ENST00000263817.6	-	28	3923	c.3799G>A	c.(3799-3801)Ggt>Agt	p.G1267S		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1267	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CAGGTCCGACCCTCTCTGGCT	0.527000													10	37					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927586	92927586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:92927586C>T	ENST00000373079.3	-	1	981	c.718G>A	c.(718-720)Gac>Aac	p.D240N	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	240	Glu-rich.				nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TCCATACAGTCTTTAGAATCT	0.418000													67	43					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899666	233899666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233899666C>T	ENST00000233840.3	+	2	1042	c.1042C>T	c.(1042-1044)Ccc>Tcc	p.P348S		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	348							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		TGATGGGTCCCCCTTGTTTGG	0.587000													78	181					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37536457	37536457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:37536457G>A	ENST00000299824.1	+	9	1096	c.907G>A	c.(907-909)Gag>Aag	p.E303K	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.E261K	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	303					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				AGACCTGTGCGAGGAGGAAGA	0.592000													32	58					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168180021	168180021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168180021C>T	ENST00000519560.1	-	18	2331	c.1912G>A	c.(1912-1914)Gac>Aac	p.D638N	SLIT3_ENST00000332966.8_Missense_Mutation_p.D638N|SLIT3_ENST00000404867.3_Missense_Mutation_p.D638N	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	638					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCCGATTGTCATAGAGGGAC	0.572000													12	37					0	0	1	0	0
OXCT2	64064	broad.mit.edu	37	1	40236066	40236066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40236066C>T	ENST00000327582.5	-	1	954	c.862G>A	c.(862-864)Gaa>Aaa	p.E288K	BMP8B_ENST00000372827.3_Intron|BMP8B_ENST00000397360.2_Intron	NM_022120.1	NP_071403.1	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2	288					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|pancreas(1)|upper_aerodigestive_tract(1)	6	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	TCTCCATCTTCCTCTTTCAGG	0.517000											OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	241					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61525396	61525396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61525396G>A	ENST00000266070.4	-	12	3048	c.2723C>T	c.(2722-2724)cCt>cTt	p.P908L	DIDO1_ENST00000395340.1_Missense_Mutation_p.P908L|DIDO1_ENST00000395343.1_Missense_Mutation_p.P908L|DIDO1_ENST00000395335.2_Missense_Mutation_p.P908L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	908					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GGCAACTTCAGGCACAGCCTC	0.532000													47	89					0	0	1	0	0
ANKRD13A	88455	broad.mit.edu	37	12	110463607	110463607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110463607G>A	ENST00000261739.4	+	8	1028	c.862G>A	c.(862-864)Gag>Aag	p.E288K		NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	288										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						TCTGACCGAGGAGGAAAAAAA	0.408000													43	94					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104341555	104341555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104341555C>T	ENST00000361820.3	-	7	3454	c.2854G>A	c.(2854-2856)Gag>Aag	p.E952K		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	952	PPP2CB binding site (By similarity).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ACTATGTGCTCACCAATGGTG	0.478000													8	44					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3313082	3313082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3313082G>A	ENST00000378398.3	+	6	686	c.604G>A	c.(604-606)Gag>Aag	p.E202K	PRDM16_ENST00000378391.2_Missense_Mutation_p.E201K|PRDM16_ENST00000442529.2_Missense_Mutation_p.E201K|PRDM16_ENST00000441472.2_Missense_Mutation_p.E201K|PRDM16_ENST00000514189.1_Missense_Mutation_p.E202K|PRDM16_ENST00000511072.1_Missense_Mutation_p.E202K|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Missense_Mutation_p.E201K			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	201	SET.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TAAGGACATTGAGCCAGGTGA	0.572000			T	EVI1	"""MDS, AML"""								5	13					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39149936	39149936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:39149936G>A	ENST00000297668.6	-	10	1589	c.1516C>T	c.(1516-1518)Ccc>Tcc	p.P506S	CNTNAP3_ENST00000377656.2_Missense_Mutation_p.P506S|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.P418S|CNTNAP3_ENST00000323947.7_Intron|CNTNAP3_ENST00000377659.1_Missense_Mutation_p.P506S	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	506	Laminin G-like 2.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CCTCCCAGGGGGCTTTTACAT	0.493000													15	48					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62257019	62257019	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62257019G>A	ENST00000371158.2	+	9	1182		c.e9-1		INADL_ENST00000316485.6_Splice_Site	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)						intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TTTCCTTTTAGGACAGTTCTC	0.338000													7	63					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74017761	74017761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74017761G>A	ENST00000301607.3	-	8	1162	c.909C>T	c.(907-909)ccC>ccT	p.P303P	EVPL_ENST00000586740.1_Silent_p.P303P	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	303	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						gcaccTGGATGGGCCCCACCG	0.721000													4	14					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28272835	28272835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28272835C>T	ENST00000305242.5	-	6	848	c.756G>A	c.(754-756)gtG>gtA	p.V252V	ARMC4_ENST00000239715.3_Silent_p.V109V	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	252							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CGTGAGGTTTCACCAGCACAT	0.393000													27	57					0	0	1	0	0
SLC22A12	116085	broad.mit.edu	37	11	64368270	64368270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64368270C>T	ENST00000377574.1	+	9	2205	c.1458C>T	c.(1456-1458)gtC>gtT	p.V486V	SLC22A12_ENST00000377567.2_Silent_p.V378V|SLC22A12_ENST00000473690.1_Silent_p.V265V|SLC22A12_ENST00000377572.1_Silent_p.V378V|SLC22A12_ENST00000336464.7_Silent_p.V452V	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	486					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						GGCCTCTGGTCCGGCTGCTGG	0.657000													24	60					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57383352	57383352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57383352C>T	ENST00000361249.3	+	11	1814	c.1718C>T	c.(1717-1719)tCg>tTg	p.S573L		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	573	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGAGGGGCCTCGTGTCCAGGG	0.582000													21	55					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40719431	40719431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40719431C>T	ENST00000253055.3	+	9	2133	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	615					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						CAGAGGAGTTCGCGGAGGCAG	0.706000													8	37					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11067176	11067176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11067176C>T	ENST00000287766.4	+	8	1177	c.756C>T	c.(754-756)atC>atT	p.I252I	SLC6A1_ENST00000536032.1_Silent_p.I74I	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	252					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCATGCTGATCATCCTGTTCT	0.572000													22	35					0	0	1	0	0
TRBV11-1	28582	broad.mit.edu	37	7	142223992	142223992	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142223992C>T	ENST00000390367.3	-	0	191																											GGGCCCTGTCCCAGGATCTGC	0.488000													23	65					0	0	1	0	0
LRRC14	9684	broad.mit.edu	37	8	145745326	145745326	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145745326C>A	ENST00000292524.1	+	2	363	c.217C>A	c.(217-219)Cgt>Agt	p.R73S	LRRC14_ENST00000529022.1_Missense_Mutation_p.R73S	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	73										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCACTGCAGCCGTGCCCTCCT	0.627000													16	68					2.35188e-11	2.36167e-11	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	79878690	79878690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79878690C>T	ENST00000466387.1	+	6	732	c.8C>T	c.(7-9)tCg>tTg	p.S3L	CTNNA2_ENST00000409266.1_Missense_Mutation_p.S3L|CTNNA2_ENST00000402739.4_Missense_Mutation_p.S3L|CTNNA2_ENST00000361291.4_Missense_Mutation_p.S37L|CTNNA2_ENST00000496558.1_Missense_Mutation_p.S3L|CTNNA2_ENST00000540488.1_Missense_Mutation_p.S3L|CTNNA2_ENST00000541047.1_Missense_Mutation_p.S3L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	3					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AGCATGACTTCGGCAACTTCA	0.403000													26	69					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16816494	16816494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:16816494C>T	ENST00000355661.3	-	18	2491	c.2481G>A	c.(2479-2481)gaG>gaA	p.E827E	PLEKHA7_ENST00000448080.2_Silent_p.E827E|PLEKHA7_ENST00000531066.1_Silent_p.E827E|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	827					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TTCTGAAGTTCTCTTTATTTG	0.483000													73	171					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189012653	189012653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189012653G>A	ENST00000512729.1	-	7	1412	c.1038C>T	c.(1036-1038)tcC>tcT	p.S346S	TRIML2_ENST00000326754.3_Silent_p.S371S	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	346	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AGGCGCAATGGGAGAAATTGT	0.478000													51	105					0	0	1	0	0
PROK2	60675	broad.mit.edu	37	3	71821914	71821914	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:71821914C>T	ENST00000353065.3	-	3	441	c.288G>A	c.(286-288)cgG>cgA	p.R96R	PROK2_ENST00000295619.3_Silent_p.R117R	NM_021935.3	NP_068754.1	Q9HC23	PROK2_HUMAN	prokineticin 2	117					activation of MAPK activity|angiogenesis|anti-apoptosis|cell proliferation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response|neuropeptide signaling pathway|positive regulation of smooth muscle contraction|sensory perception of pain|spermatogenesis	extracellular region	G-protein-coupled receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.89e-05)|Epithelial(33;0.000173)|LUSC - Lung squamous cell carcinoma(21;0.00168)|Lung(16;0.00306)		TAAATGAAGTCCGTAAACAGG	0.418000													28	82					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111158883	111158883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111158883G>A	ENST00000360467.5	+	46	4830	c.4524G>A	c.(4522-4524)atG>atA	p.M1508I	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1508	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAGTGGGCATGAACAAACTCT	0.657000													12	15					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23898557	23898557	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23898557C>T	ENST00000355349.3	-	13	1301		c.e13-1			NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta						adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTGTCAGCCTCTGGAAGGAAA	0.557000													26	50					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103573705	103573705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103573705C>T	ENST00000358392.2	-	1	347	c.30G>A	c.(28-30)acG>acA	p.T10T	COL11A1_ENST00000512756.1_Silent_p.T10T|COL11A1_ENST00000353414.4_Silent_p.T10T|COL11A1_ENST00000370096.3_Silent_p.T10T	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	10					collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCCACCGTTTCGTTTTCCACC	0.522000													18	43					0	0	1	0	0
NAIP	4671	broad.mit.edu	37	5	70308413	70308413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:70308413C>T	ENST00000517649.1	-	4	620	c.330G>A	c.(328-330)acG>acA	p.T110T	NAIP_ENST00000503719.2_Intron|NAIP_ENST00000523981.1_Intron|NAIP_ENST00000508426.2_Silent_p.T110T|NAIP_ENST00000194097.4_Silent_p.T110T	NM_004536.2	NP_004527.2	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein	110					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		TGGGGAGTCTCGTGAGGCCGG	0.493000													26	113					0	0	1	0	0
MS4A3	932	broad.mit.edu	37	11	59830030	59830030	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59830030C>T	ENST00000278865.3	+	3	319	c.246C>T	c.(244-246)ttC>ttT	p.F82F	MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000534744.1_Intron|MS4A3_ENST00000358152.2_Intron	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	82	Poly-Phe.					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				AAAAGCACTTCTTTTTCTTCA	0.453000													53	116					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155340754	155340754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155340754G>A	ENST00000368346.3	-	11	7007	c.6368C>T	c.(6367-6369)tCc>tTc	p.S2123F	ASH1L_ENST00000392403.3_Missense_Mutation_p.S2118F			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2123	AWS.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			AGTGTTGGGGGAACACTCAGC	0.393000													20	50					0	0	1	0	0
KLHL30	377007	broad.mit.edu	37	2	239049585	239049585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239049585G>A	ENST00000409223.1	+	2	297	c.190G>A	c.(190-192)Ggt>Agt	p.G64S	KLHL30_ENST00000305959.4_Missense_Mutation_p.G46S			Q0D2K2	KLH30_HUMAN	kelch-like family member 30	64	BTB.									lung(4)	4		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CATGTTTGCGGGTGACTTCGC	0.682000													9	175					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43945658	43945658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43945658C>T	ENST00000389420.3	-	1	66	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E23K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	23						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAGTCAACTTCCCAAGACCTG	0.652000													22	83					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33623571	33623571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33623571C>T	ENST00000374316.5	+	4	1249	c.189C>T	c.(187-189)aaC>aaT	p.N63N	ITPR3_ENST00000605930.1_Silent_p.N63N			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	63					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GCCCCATGAACCGCTACTCGG	0.582000													5	48					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53012266	53012266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53012266C>T	ENST00000305748.3	-	1	77	c.43G>A	c.(43-45)Ggg>Agg	p.G15R		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	15	Gly-rich.|Head.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTGAAGCCCCCCTTGGCAGCA	0.617000													21	79					0	0	1	0	0
EEF1DP3	196549	broad.mit.edu	37	13	32526950	32526950	+	RNA	SNP	C	C	T	rs151166105	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32526950C>T	ENST00000428783.1	+	0	650																											ACAGCGAGCTCGTCGTCCGGA	0.637000													8	20					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107811990	107811990	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107811990G>A	ENST00000328300.6	+	6	567	c.321_splice	c.e6-1	p.G108_splice	COL4A5_ENST00000361603.2_Splice_Site_p.G108_splice	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	108	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TTTTCAAAGGGAATGCCAGGC	0.423000									Alport syndrome with Diffuse Leiomyomatosis				17	78					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92346066	92346066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:92346066G>A	ENST00000377067.3	+	3	1323	c.951G>A	c.(949-951)ctG>ctA	p.L317L		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	317						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ACGTGCTGCTGAACTTTCACT	0.453000													32	111					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39906027	39906027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39906027G>A	ENST00000425673.1	+	4	752	c.427G>A	c.(427-429)Gag>Aag	p.E143K	PLEKHG2_ENST00000458508.2_Missense_Mutation_p.E84K|PLEKHG2_ENST00000378550.1_Missense_Mutation_p.E143K|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.E143K|PLEKHG2_ENST00000409797.2_Missense_Mutation_p.E143K			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	143	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCTGAGCGTGGAGCAGGTGGG	0.647000													22	42					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28714076	28714076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28714076G>A	ENST00000257197.3	-	13	2155	c.1894C>T	c.(1894-1896)Cgt>Tgt	p.R632C	DSC1_ENST00000257198.5_Missense_Mutation_p.R632C|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	632	Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TGCCGTTGACGAAGAATGGCA	0.353000													33	79					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94993217	94993217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94993217C>T	ENST00000265627.5	-	6	663	c.653G>A	c.(652-654)gGa>gAa	p.G218E	PON1_ENST00000542556.1_Intron|PON3_ENST00000427422.1_Missense_Mutation_p.G218E	NM_000940.2	NP_000931.1			paraoxonase 3									p.G218E(1)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			ACTACAAAATCCTTTGGCCAC	0.428000													81	184					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410237	105410237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105410237G>A	ENST00000333244.5	-	7	11670	c.11551C>T	c.(11551-11553)Ctc>Ttc	p.L3851F	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3851						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGAATGCTGAGGTCAGTGGTC	0.632000													84	180					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105412371	105412371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:105412371G>A	ENST00000264122.4	-	13	2342	c.2021C>T	c.(2020-2022)cCt>cTt	p.P674L	CBLB_ENST00000394027.3_Missense_Mutation_p.P696L|CBLB_ENST00000403724.1_Missense_Mutation_p.P674L|CBLB_ENST00000405772.1_Missense_Mutation_p.P674L	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	674	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						AACTGGAGGAGGAGGAGAAAG	0.413000			Mis S		AML								20	32					0	0	1	0	0
NDOR1	27158	broad.mit.edu	37	9	140109069	140109069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140109069C>T	ENST00000371521.4	+	7	853	c.770C>T	c.(769-771)gCc>gTc	p.A257V	NDOR1_ENST00000458322.2_Missense_Mutation_p.A257V|NDOR1_ENST00000344894.5_Missense_Mutation_p.A257V|NDOR1_ENST00000427047.2_Missense_Mutation_p.A223V	NM_001144026.1	NP_001137498.1	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	257	FAD-binding FR-type.				cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding			breast(1)|endometrium(5)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		AACTCGGCTGCCCATGTCCAG	0.662000													11	39					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29005439	29005439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29005439C>T	ENST00000282397.4	-	7	1073	c.822G>A	c.(820-822)aaG>aaA	p.K274K	FLT1_ENST00000541932.1_Silent_p.K274K|FLT1_ENST00000539099.1_Silent_p.K274K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	274	Ig-like C2-type 3.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CGGAAGCTCTCTTATTTTTCT	0.338000													21	41					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44449850	44449850	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:44449850G>C	ENST00000360029.3	-	1	974	c.691C>G	c.(691-693)Cgt>Ggt	p.R231G		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	231						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CGCGCCACACGCCGGAATTTG	0.711000										HNSCC(17;0.042)			5	10					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436215	248436215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248436215C>T	ENST00000318021.2	-	1	923	c.902G>A	c.(901-903)cGg>cAg	p.R301Q		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCCCAGCCACCGTTTCAGGGC	0.438000													100	207					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108863374	108863374	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:108863374G>A	ENST00000356922.4	-	2	515	c.243C>T	c.(241-243)gcC>gcT	p.A81A	LIG4_ENST00000442234.1_Silent_p.A81A|LIG4_ENST00000405925.1_Silent_p.A81A	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	81					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TAATTCCATAGGCCATTCTCT	0.353000								Non-homologous end-joining					38	125					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130877816	130877816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130877816C>T	ENST00000357462.5	-	1	366	c.273G>A	c.(271-273)atG>atA	p.M91I	POTEF_ENST00000360967.5_Missense_Mutation_p.M91I|POTEF_ENST00000409914.2_Missense_Mutation_p.M91I|POTEF_ENST00000361163.4_Missense_Mutation_p.M91I			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	91						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TGAGTGTCTTCATAGCAGAGT	0.617000													38	340					0	0	1	0	0
PURG	29942	broad.mit.edu	37	8	30889982	30889982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30889982G>A	ENST00000475541.1	-	1	1249	c.317C>T	c.(316-318)aCc>aTc	p.T106I	PURG_ENST00000339382.2_Missense_Mutation_p.T106I	NM_013357.2	NP_037489.1	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G	106						nucleus	DNA binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CAGGGAGAGGGTCAGTTTACT	0.577000													24	61					0	0	1	0	0
PAK4	10298	broad.mit.edu	37	19	39660289	39660289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39660289C>T	ENST00000599386.1	+	3	277	c.96C>T	c.(94-96)ttC>ttT	p.F32F	PAK4_ENST00000599470.1_Silent_p.F32F|PAK4_ENST00000321944.4_Silent_p.F32F|PAK4_ENST00000358301.3_Silent_p.F32F|PAK4_ENST00000593690.1_Silent_p.F32F|PAK4_ENST00000435673.2_Silent_p.F32F|PAK4_ENST00000360442.3_Silent_p.F32F	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	32	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			AGCAGAAGTTCACGGGGCTGC	0.677000													20	61					0	0	1	0	0
TPSB2	64499	broad.mit.edu	37	16	1279691	1279691	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1279691C>T	ENST00000430512.2	-	0	160				TPSB2_ENST00000339687.6_RNA|TPSB2_ENST00000445910.1_RNA	NM_024164.5	NP_077078.5	P20231	TRYB2_HUMAN	tryptase beta 2 (gene/pseudogene)						proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			lung(1)|upper_aerodigestive_tract(1)	2		Hepatocellular(780;0.00369)				CTCCTGGGGGCCTCCTGACCC	0.701000													14	56					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26725395	26725395	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26725395C>T	ENST00000396005.3	-	5	934	c.625G>A	c.(625-627)Gga>Aga	p.G209R	SLC5A12_ENST00000280467.6_Missense_Mutation_p.G209R	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	209					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						TTGTGGAATCCCCCAGCATGA	0.398000													62	169					0	0	1	0	0
TTC38	55020	broad.mit.edu	37	22	46685431	46685431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46685431C>T	ENST00000381031.3	+	12	1291	c.1215C>T	c.(1213-1215)atC>atT	p.I405I	TTC38_ENST00000445282.2_Silent_p.I347I	NM_017931.2	NP_060401.2	Q5R3I4	TTC38_HUMAN	tetratricopeptide repeat domain 38	405							binding			endometrium(4)|large_intestine(3)|lung(4)|ovary(1)	12						GCTACCGGATCGTCCAGCTCG	0.721000													8	25					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22202044	22202044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:22202044C>T	ENST00000344041.6	-	13	1252	c.940G>A	c.(940-942)Gaa>Aaa	p.E314K	RAPGEF5_ENST00000401957.2_Missense_Mutation_p.E164K	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	164					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						TGTTCATCTTCAGGTAACCAG	0.343000													21	61					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20790053	20790053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20790053C>T	ENST00000359062.3	+	9	2061	c.2021C>T	c.(2020-2022)cCc>cTc	p.P674L	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	674					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ATTCTTGCTCCCGAACCTCTT	0.333000													18	36					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204289	9204289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9204289C>T	ENST00000429566.3	+	1	435	c.369C>T	c.(367-369)ttC>ttT	p.F123F		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						ATGACCGGTTCGTGGCCATCT	0.552000													30	60					0	0	1	0	0
WISP2	8839	broad.mit.edu	37	20	43355922	43355922	+	Missense_Mutation	SNP	C	C	T	rs144332553	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43355922C>T	ENST00000372868.2	+	5	1070	c.727C>T	c.(727-729)Cgc>Tgc	p.R243C	RP11-445H22.4_ENST00000445420.1_RNA|WISP2_ENST00000471629.1_3'UTR|RP11-445H22.4_ENST00000427598.1_RNA|WISP2_ENST00000190983.4_Missense_Mutation_p.R243C|WISP2_ENST00000372865.4_Silent_p.V160V|RP11-445H22.4_ENST00000427303.1_RNA			O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	243					cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CTCCAGGGGTCGCAGTCCACA	0.682000													9	32					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70672746	70672746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70672746G>A	ENST00000322773.4	+	11	1112	c.1010G>A	c.(1009-1011)gGa>gAa	p.G337E		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	337	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GGCAGCAAAGGAGAAACTGGT	0.274000													17	43					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60463381	60463381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60463381C>T	ENST00000371201.3	-	11	1487	c.1380G>A	c.(1378-1380)gtG>gtA	p.V460V	C1orf87_ENST00000486478.1_5'UTR|C1orf87_ENST00000395552.1_Silent_p.V94V|C1orf87_ENST00000450089.2_Silent_p.V231V	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	460							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CAGCTGGATTCACGAAGGGCT	0.502000													22	53					0	0	1	0	0
RABEP1	9135	broad.mit.edu	37	17	5241338	5241338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:5241338C>T	ENST00000262477.6	+	5	777	c.553C>T	c.(553-555)Cgg>Tgg	p.R185W	RABEP1_ENST00000546142.2_Missense_Mutation_p.R185W|RABEP1_ENST00000341923.6_Missense_Mutation_p.R185W|RABEP1_ENST00000537505.1_Missense_Mutation_p.R142W|RABEP1_ENST00000408982.2_Missense_Mutation_p.R185W	NM_004703.4	NP_004694.2	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	185					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	8						TGAGAAACTTCGGTCCGTTGT	0.398000													48	63					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588319	93588319	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93588319G>A	ENST00000329082.7	-	4	1533	c.1262C>T	c.(1261-1263)cCa>cTa	p.P421L	RGMA_ENST00000543599.1_Missense_Mutation_p.P405L|RGMA_ENST00000538818.1_Missense_Mutation_p.P312L|RGMA_ENST00000557420.1_3'UTR|RGMA_ENST00000425933.2_Missense_Mutation_p.P405L|RGMA_ENST00000557301.1_Missense_Mutation_p.P429L|RGMA_ENST00000556658.1_Missense_Mutation_p.P312L|RGMA_ENST00000542321.2_Missense_Mutation_p.P405L	NM_020211.2	NP_064596.2	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	421					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			CGCCCTGCCTGGCAGGTCCCG	0.647000													6	5					0	0	1	0	0
RASL11A	387496	broad.mit.edu	37	13	27847178	27847178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:27847178C>T	ENST00000241463.4	+	4	894	c.276C>T	c.(274-276)ctC>ctT	p.L92L	RASL11A_ENST00000480803.1_3'UTR	NM_206827.1	NP_996563.1	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	92	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	10		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		AAGACAGCCTCCCCCAGGTCG	0.488000													25	66					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30998884	30998884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:30998884C>T	ENST00000295055.8	-	4	475	c.299G>A	c.(298-300)gGa>gAa	p.G100E	CAPN13_ENST00000465960.2_5'UTR|CAPN13_ENST00000534090.2_Missense_Mutation_p.G100E	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	100	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AGTCAAGGATCCCAGTGCTGC	0.527000													17	33					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72020966	72020966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72020966G>A	ENST00000355327.3	+	9	1570	c.1436G>A	c.(1435-1437)gGg>gAg	p.G479E	THSD4_ENST00000261862.6_Missense_Mutation_p.G479E|THSD4_ENST00000357769.4_Missense_Mutation_p.G119E|THSD4_ENST00000567838.1_3'UTR			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	479						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GAGGGCGGAGGGACCATGTTC	0.512000													20	238					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128186496	128186496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128186496G>A	ENST00000453608.2	+	8	1533	c.1525G>A	c.(1525-1527)Gcc>Acc	p.A509T	PROC_ENST00000409048.1_Missense_Mutation_p.A488T|PROC_ENST00000422777.3_Missense_Mutation_p.A454T|PROC_ENST00000234071.3_Missense_Mutation_p.A454T			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	454					blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	AGACAAGGAAGCCCCCCAGAA	0.577000													10	115					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84188309	84188309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84188309G>A	ENST00000378553.5	+	4	604	c.480G>A	c.(478-480)atG>atA	p.M160I	DNAAF1_ENST00000334315.5_Missense_Mutation_p.M160I	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	160					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						TCTTGCAAATGAACTTGCTCC	0.463000													35	80					0	0	1	0	0
GALNT12	79695	broad.mit.edu	37	9	101585705	101585705	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101585705G>T	ENST00000375011.3	+	2	539	c.539G>T	c.(538-540)aGa>aTa	p.R180I		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	180	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.R180I(1)		breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				TACAGTGATAGAGGTGAGTCC	0.537000													12	54					0.00185496	0.00185674	1	1	0
TMEM255A	55026	broad.mit.edu	37	X	119419520	119419520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:119419520G>A	ENST00000309720.5	-	6	578	c.455C>T	c.(454-456)tCc>tTc	p.S152F	TMEM255A_ENST00000371369.4_Intron|TMEM255A_ENST00000440464.1_Intron|TMEM255A_ENST00000371352.1_Intron	NM_017938.3	NP_060408.3			transmembrane protein 255A																		AACCCTCGTGGAAGGAGAATT	0.448000													22	27					0	0	1	0	0
CPNE6	9362	broad.mit.edu	37	14	24544463	24544463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24544463G>A	ENST00000397016.2	+	9	1066	c.755G>A	c.(754-756)gGg>gAg	p.G252E	CPNE6_ENST00000216775.2_Missense_Mutation_p.G252E|CPNE6_ENST00000537691.1_Missense_Mutation_p.G307E			O95741	CPNE6_HUMAN	copine VI (neuronal)	252					lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		ATGCAGGAAGGGACGGCAAAC	0.572000													42	119					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78466040	78466040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78466040C>T	ENST00000258873.4	-	13	2189	c.1984G>A	c.(1984-1986)Gaa>Aaa	p.E662K	ACSBG1_ENST00000560817.1_Missense_Mutation_p.E420K|ACSBG1_ENST00000541759.1_Missense_Mutation_p.E420K	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	662					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						ATCCCCTCTTCGATGGCCTGG	0.582000													11	110					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22389807	22389807	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:22389807G>A	ENST00000334304.5	-	19	3756	c.3487C>T	c.(3487-3489)Cga>Tga	p.R1163*	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	1163					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				ACATTTGTTCGAAACTGAACT	0.448000													26	60					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42747236	42747236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42747236C>T	ENST00000372980.3	-	3	2069	c.1197G>A	c.(1195-1197)gaG>gaA	p.E399E		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	399	Ala-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GTTCCGCTGCCTCAGCTTTGG	0.607000													56	126					0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5331432	5331432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5331432C>T	ENST00000396872.2	+	5	685	c.524C>T	c.(523-525)aCc>aTc	p.T175I	SLC29A4_ENST00000406453.3_Missense_Mutation_p.P163S|SLC29A4_ENST00000297195.4_Missense_Mutation_p.T175I	NM_001040661.1|NM_153247.2	NP_001035751.1|NP_694979.2	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4	175					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GCTGTGGGCACCGTGGCCTTC	0.647000													11	82					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535616	27535616	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27535616G>A	ENST00000574842.1	+	0	255																											ATGGGTCTCAGAGCAGTCCAT	0.493000													48	209					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113353798	113353798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113353798G>A	ENST00000297405.5	-	42	6804	c.6560C>T	c.(6559-6561)cCa>cTa	p.P2187L	CSMD3_ENST00000455883.2_Missense_Mutation_p.P2083L|CSMD3_ENST00000343508.3_Missense_Mutation_p.P2147L|CSMD3_ENST00000352409.3_Missense_Mutation_p.P2117L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2187	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TAAGGAAGATGGTATTTGAGG	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			24	70					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110495667	110495667	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:110495667G>A	ENST00000324068.1	-	5	734	c.567C>T	c.(565-567)ttC>ttT	p.F189F	CAPN6_ENST00000541758.1_Intron	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	189	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						ATGTGCCCGTGAAGTCCACAA	0.423000													32	26					0	0	1	0	0
TAS2R8	50836	broad.mit.edu	37	12	10958981	10958981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10958981G>A	ENST00000240615.2	-	1	911	c.599C>T	c.(598-600)tCa>tTa	p.S200L		NM_023918.1	NP_076407.1	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	200					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						AAGGAAAAATGATATCAGTGA	0.378000													42	66					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13717553	13717553	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13717553G>A	ENST00000265104.4	-	73	12680	c.12576C>T	c.(12574-12576)caC>caT	p.H4192H		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4192	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGACAGTGGAGTGCAGGAAAG	0.547000									Kartagener syndrome				14	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179414035	179414035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179414035C>T	ENST00000589042.1	-	339	92542	c.92318G>A	c.(92317-92319)cGa>cAa	p.R30773Q	RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R28205Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R29132Q|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R21900Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R21833Q|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R21708Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29132	Fibronectin type-III 124.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGATTGGTCGTTTGCTGAT	0.428000													30	84					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28285047	28285047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28285047G>A	ENST00000373894.3	+	8	1257	c.1066G>A	c.(1066-1068)Gag>Aag	p.E356K	SMPDL3B_ENST00000549094.1_Missense_Mutation_p.E308K|RP11-460I13.2_ENST00000448015.1_RNA	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	356					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		GCCGCGCTGGGAGCTCGAGTA	0.627000													8	76					0	0	1	0	0
CYP3A43	64816	broad.mit.edu	37	7	99459391	99459391	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99459391G>A	ENST00000354829.2	+	11	1285	c.1182G>A	c.(1180-1182)gtG>gtA	p.V394V	CYP3A43_ENST00000312017.5_Silent_p.V394V|CYP3A43_ENST00000444905.1_Silent_p.V141V|CYP3A43_ENST00000477658.1_3'UTR|CYP3A43_ENST00000415413.1_Silent_p.V183V|CYP3A43_ENST00000342499.4_Silent_p.V254V|CYP3A43_ENST00000417625.1_Silent_p.V284V|CYP3A43_ENST00000222382.5_Silent_p.V394V	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	394			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	GGTTAGCAGTGATGGTTCCAA	0.458000													40	82					0	0	1	0	0
ABCD3	5825	broad.mit.edu	37	1	94964161	94964161	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94964161C>T	ENST00000370214.4	+	17	1414	c.1390C>T	c.(1390-1392)Cga>Tga	p.R464*	ABCD3_ENST00000484213.1_3'UTR|ABCD3_ENST00000536817.1_Nonsense_Mutation_p.R391*|ABCD3_ENST00000394233.2_Nonsense_Mutation_p.R354*|ABCD3_ENST00000454898.2_Nonsense_Mutation_p.R488*	NM_002858.3	NP_002849.1	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D (ALD), member 3	464	ABC transporter.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTTTCAGGTTCGATCTGGGGC	0.338000													12	59					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159086542	159086542	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159086542C>T	ENST00000297239.9	+	4	420	c.226C>T	c.(226-228)Cgg>Tgg	p.R76W	SYTL3_ENST00000367081.3_5'UTR|SYTL3_ENST00000360448.3_Missense_Mutation_p.R76W			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	76	RabBD.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		CCTGCTGCACCGGGGCGCCGT	0.662000													8	2					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57745930	57745930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57745930G>A	ENST00000281282.5	+	7	2182	c.2104G>A	c.(2104-2106)Gat>Aat	p.D702N		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	702						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TGAGATCAGGGATCTCCAGGA	0.537000													5	27					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18768348	18768348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18768348C>T	ENST00000359846.2	-	3	289	c.212G>A	c.(211-213)gGa>gAa	p.G71E	NT5C1B_ENST00000460052.1_Intron|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.G71E|NT5C1B_ENST00000600945.1_Missense_Mutation_p.G71E|NT5C1B_ENST00000304081.4_Intron	NM_001002006.2|NM_001199086.1|NM_001199087.1|NM_001199088.1	NP_001002006.1|NP_001186015.1|NP_001186016.1|NP_001186017.1			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AAGGGCTGTTCCCTCAGCTGC	0.537000													18	34					0	0	1	0	0
TRIM60	166655	broad.mit.edu	37	4	165962504	165962504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:165962504C>T	ENST00000512596.1	+	3	1496	c.1280C>T	c.(1279-1281)tCc>tTc	p.S427F	TRIM60_ENST00000508504.1_Missense_Mutation_p.S427F|TRIM60_ENST00000341062.5_Missense_Mutation_p.S427F	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	427	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		GGTGATCTTTCCTTTTATAAT	0.378000													36	81					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5036231	5036231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:5036231G>A	ENST00000574788.1	+	13	2452	c.222G>A	c.(220-222)acG>acA	p.T74T	USP6_ENST00000332776.4_Silent_p.T74T|USP6_ENST00000572429.1_3'UTR|USP6_ENST00000304328.5_5'UTR|USP6_ENST00000250066.6_Silent_p.T74T			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	74					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TGACACGAACGAGCAAGTGGA	0.527000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								19	179					0	0	1	0	0
CCNB1IP1	57820	broad.mit.edu	37	14	20781668	20781668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20781668G>A	ENST00000398169.3	-	6	1206	c.590C>T	c.(589-591)cCa>cTa	p.P197L	CCNB1IP1_ENST00000398163.2_Missense_Mutation_p.P197L|CCNB1IP1_ENST00000398160.2_Missense_Mutation_p.P197L|CCNB1IP1_ENST00000353689.4_Missense_Mutation_p.P197L|CCNB1IP1_ENST00000358932.4_Missense_Mutation_p.P197L|CCNB1IP1_ENST00000437553.2_Missense_Mutation_p.P197L			Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1, E3 ubiquitin protein ligase	197						chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	9	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		AATCATGGATGGTTCAAGGGT	0.418000			T	HMGA2	leiomyoma								27	115					0	0	1	0	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959264	45959264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45959264G>A	ENST00000400375.1	-	1	814	c.770C>T	c.(769-771)tCc>tTc	p.S257F	TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	257	24 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						GGCCTGGCAGGAGGAGGCAGG	0.726000													18	50					0	0	1	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6374257	6374257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6374257C>T	ENST00000335585.5	-	5	641	c.618G>A	c.(616-618)agG>agA	p.R206R	PPP2R2C_ENST00000382599.4_Silent_p.R206R|PPP2R2C_ENST00000515571.1_Silent_p.R189R|PPP2R2C_ENST00000314348.8_5'UTR|PPP2R2C_ENST00000506140.1_Silent_p.R199R|PPP2R2C_ENST00000507294.1_Silent_p.R199R	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	206					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						TACTGAAGCTCCTGTCGGTGA	0.577000													27	57					0	0	1	0	0
PARPBP	55010	broad.mit.edu	37	12	102569432	102569432	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102569432C>T	ENST00000327680.2	+	8	1213	c.750C>T	c.(748-750)atC>atT	p.I250I	PARPBP_ENST00000541394.1_Silent_p.I408I|PARPBP_ENST00000543784.1_Intron|PARPBP_ENST00000378128.3_Intron|PARPBP_ENST00000392911.2_Silent_p.I250I|PARPBP_ENST00000358383.5_Silent_p.I331I|PARPBP_ENST00000535811.1_Intron	NM_017915.3	NP_060385.3	Q9NWS1	PR1BP_HUMAN	PARP1 binding protein	331					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding			endometrium(1)|lung(8)|urinary_tract(2)	11						CCACTGACATCAGTCCTGCTC	0.318000													18	41					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123508947	123508947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123508947C>T	ENST00000392770.2	-	4	1333	c.531G>A	c.(529-531)atG>atA	p.M177I	SCN3B_ENST00000530277.1_Missense_Mutation_p.M177I|SCN3B_ENST00000299333.3_Missense_Mutation_p.M177I	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	177					axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		AGCAATATATCATCTCGATGA	0.453000													15	57					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4832520	4832520	+	Silent	SNP	C	C	T	rs151154079		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:4832520C>T	ENST00000378191.4	+	4	1479	c.1098C>T	c.(1096-1098)ccC>ccT	p.P366P	AJAP1_ENST00000378190.3_Silent_p.P366P	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	366	Targeting signals.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CATCTGTGCCCGTGTACACCG	0.592000													15	28					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5941682	5941682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5941682G>A	ENST00000546188.1	-	5	783	c.712C>T	c.(712-714)Cca>Tca	p.P238S	ANO2_ENST00000356134.5_Missense_Mutation_p.P238S|ANO2_ENST00000327087.8_Missense_Mutation_p.P237S			Q9NQ90	ANO2_HUMAN	anoctamin 2	242						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CTGTGTTCTGGAACTCGGGGC	0.507000													20	50					0	0	1	0	0
ABCG2	9429	broad.mit.edu	37	4	89036161	89036161	+	Silent	SNP	G	G	A	rs144639395		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89036161G>A	ENST00000237612.3	-	8	1436	c.891C>T	c.(889-891)atC>atT	p.I297I	ABCG2_ENST00000515655.1_Silent_p.I297I	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	297					cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	CTCCATTAATGATGTCCAAGA	0.383000													13	63					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79341864	79341864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79341864C>T	ENST00000419573.3	-	4	872	c.598G>A	c.(598-600)Gac>Aac	p.D200N	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.D200N	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	200					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ATGTCGCTGTCTTCATCGTTG	0.547000													15	65					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47569694	47569694	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47569694G>A	ENST00000253048.5	-	15	3868	c.3831C>T	c.(3829-3831)gcC>gcT	p.A1277A	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1277							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CACCCTCGCGGGCCGGACTGT	0.637000													5	1					0	0	1	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44420688	44420688	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44420688G>A	ENST00000372622.3	+	1	113	c.45G>A	c.(43-45)ggG>ggA	p.G15G		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	15						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				GACCTAGCGGGGCCGAGAGGG	0.751000													6	11					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11700964	11700964	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11700964C>T	ENST00000262442.3	+	43	8342	c.8274C>T	c.(8272-8274)caC>caT	p.H2758H	DNAH9_ENST00000454412.2_Silent_p.H2758H	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2758					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGTATTGTCACTTTGCAAATG	0.493000													17	32					0	0	1	0	0
PRSS55	203074	broad.mit.edu	37	8	10387029	10387029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10387029G>A	ENST00000328655.3	+	2	207	c.167G>A	c.(166-168)aGa>aAa	p.R56K	PRSS51_ENST00000523024.1_RNA|PRSS55_ENST00000522210.1_Missense_Mutation_p.R56K	NM_198464.3	NP_940866.2	Q6UWB4	PRS55_HUMAN	protease, serine, 55	56					proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						TGTGGTGACAGATCTATTTTC	0.532000													42	124					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40677882	40677882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40677882C>T	ENST00000298910.7	+	19	2505	c.2447C>T	c.(2446-2448)tCt>tTt	p.S816F	LRRK2_ENST00000343742.2_Missense_Mutation_p.S816F	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	816					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTTGAACCTTCTTGGCTTGGT	0.368000													10	97					0	0	1	0	0
KDM7A	80853	broad.mit.edu	37	7	139826473	139826473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139826473G>A	ENST00000397560.2	-	6	949	c.852C>T	c.(850-852)gaC>gaT	p.D284D	JHDM1D_ENST00000006967.5_Silent_p.D284D	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		284	JmjC.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					TTCCACCGAAGTCAATGTGGA	0.398000													53	113					0	0	1	0	0
C16orf90	646174	broad.mit.edu	37	16	3544772	3544772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3544772C>T	ENST00000437192.3	-	2	154	c.152G>A	c.(151-153)gGa>gAa	p.G51E	LA16c-306E5.3_ENST00000574423.2_RNA	NM_001080524.1	NP_001073993.1	A8MZG2	CP090_HUMAN	chromosome 16 open reading frame 90	41										large_intestine(1)	1						GGGCTTGCTTCCCTGGGCACT	0.716000													7	10					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439455	150439455	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150439455G>A	ENST00000358647.3	+	3	595	c.228G>A	c.(226-228)agG>agA	p.R76R	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAACGGGAGGAAAGTCCTGG	0.582000													28	48					0	0	1	0	0
TRBV10-1	28585	broad.mit.edu	37	7	142232051	142232051	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142232051C>T	ENST00000390364.3	-	0	39																											TCTTGTGTCTCCCAGCCCTGC	0.577000													7	35					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541145	40541145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40541145G>A	ENST00000434248.1	-	5	1686	c.1621C>T	c.(1621-1623)Cac>Tac	p.H541Y	ZNF780B_ENST00000221355.6_Missense_Mutation_p.H393Y	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	541					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGTTGTAGGTGAAGTCTAAAA	0.418000													13	106					0	0	1	0	0
LSM14A	26065	broad.mit.edu	37	19	34699853	34699853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:34699853C>T	ENST00000544216.3	+	4	512	c.435C>T	c.(433-435)tcC>tcT	p.S145S	LSM14A_ENST00000433627.5_Silent_p.S145S|LSM14A_ENST00000540746.2_Intron	NM_015578.2	NP_056393.2	Q8ND56	LS14A_HUMAN	LSM14A, SCD6 homolog A (S. cerevisiae)	145					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					CTTTGACATCCTTTGGAACAG	0.328000													8	27					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51287566	51287566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:51287566G>A	ENST00000395542.2	-	2	301	c.117C>T	c.(115-117)ccC>ccT	p.P39P	COBL_ENST00000441453.1_Silent_p.P39P|COBL_ENST00000265136.7_Silent_p.P39P|COBL_ENST00000395540.2_Silent_p.P39P			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	39										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CATCGTGGGGGGGCTTCTGGT	0.607000													25	58					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40392512	40392512	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40392512G>A	ENST00000221347.6	-	16	7999	c.7992C>T	c.(7990-7992)ctC>ctT	p.L2664L		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2664	VWFD 6.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCTGGAGAGGAGCCCACAGA	0.627000													10	89					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38406338	38406338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38406338G>A	ENST00000322350.5	+	7	1169	c.823G>A	c.(823-825)Gag>Aag	p.E275K	EGFLAM_ENST00000336740.6_Missense_Mutation_p.E41K|EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000354891.3_Missense_Mutation_p.E275K	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	275						cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TATTTCCTTTGAGGAGGTAAC	0.428000													12	33					0	0	1	0	0
C8orf74	203076	broad.mit.edu	37	8	10555134	10555134	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10555134G>A	ENST00000304519.5	+	3	296	c.267G>A	c.(265-267)acG>acA	p.T89T	RP1L1_ENST00000329335.3_Intron	NM_001040032.1	NP_001035121.1	Q6P047	CH074_HUMAN	chromosome 8 open reading frame 74	89										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	13				COAD - Colon adenocarcinoma(149;0.0811)		AGGCTGTGACGATCCTGGGGA	0.587000													12	142					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203029380	203029380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203029380C>T	ENST00000367240.2	+	21	3083	c.2556C>T	c.(2554-2556)gcC>gcT	p.A852A	PPFIA4_ENST00000414050.2_Silent_p.A580A|PPFIA4_ENST00000599966.1_Silent_p.A367A|PPFIA4_ENST00000447715.2_Silent_p.A851A|PPFIA4_ENST00000295706.4_Silent_p.A367A|PPFIA4_ENST00000272198.6_Silent_p.A367A			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	367					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						ATGTGGCAGCCTGCCGGGCCA	0.617000													14	41					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872836	55872836	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55872836C>T	ENST00000313503.1	+	1	318	c.318C>T	c.(316-318)ttC>ttT	p.F106F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TTTTTGCCTTCTTGGGTACTG	0.448000										HNSCC(53;0.14)			146	370					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870920	13870920	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13870920T>G	ENST00000265104.4	-	24	3894	c.3790A>C	c.(3790-3792)Agg>Cgg	p.R1264R	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1264	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGCTCCTCCCTTATTTCTTTC	0.328000									Kartagener syndrome				16	57					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140397412	140397412	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140397412C>T	ENST00000286349.3	+	1	532	c.341_splice	c.e1+1	p.S114_splice		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	114						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ATCCATACCTCGTAAGTGCCA	0.562000													8	18					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113352918	113352918	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113352918C>T	ENST00000458497.1	+	11	2494	c.2215C>T	c.(2215-2217)Caa>Taa	p.Q739*	ALPK1_ENST00000177648.9_Nonsense_Mutation_p.Q739*|ALPK1_ENST00000504176.2_Nonsense_Mutation_p.Q661*	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	739							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TCCTTCAGTCCAAAAAGAAGA	0.443000													37	64					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38565541	38565541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38565541C>T	ENST00000287675.5	+	6	891	c.795C>T	c.(793-795)ttC>ttT	p.F265F	EXOG_ENST00000422077.2_Silent_p.F215F|EXOG_ENST00000358249.2_Intron	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	265						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						TAACTGAATTCCAAGTGAGCC	0.512000													24	111					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90049587	90049587	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90049587C>A	ENST00000405460.2	+	54	11414	c.11318C>A	c.(11317-11319)cCt>cAt	p.P3773H		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3773					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATGACTCACCTTTTGGCTTG	0.428000													5	26					0.000602214	0.000602896	1	1	0
PCDH18	54510	broad.mit.edu	37	4	138452406	138452406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138452406C>T	ENST00000344876.4	-	1	1223	c.837G>A	c.(835-837)ggG>ggA	p.G279G	PCDH18_ENST00000507846.1_Silent_p.G59G|PCDH18_ENST00000412923.2_Silent_p.G279G|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	279	Cadherin 3.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ATACAATTTTCCCATTAGCGC	0.398000													27	79					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92564840	92564840	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92564840C>T	ENST00000298047.6	+	13	9551	c.9534C>T	c.(9532-9534)ttC>ttT	p.F3178F	FAT3_ENST00000525166.1_Silent_p.F3028F|FAT3_ENST00000409404.2_Silent_p.F3178F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3178	Cadherin 29.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGGGTCTTCTCCATTGACA	0.557000										TCGA Ovarian(4;0.039)			4	29					0	0	1	0	0
SELL	6402	broad.mit.edu	37	1	169677869	169677869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169677869C>T	ENST00000236147.4	-	3	360	c.200G>A	c.(199-201)aGa>aAa	p.R67K	SELL_ENST00000463108.1_5'UTR|C1orf112_ENST00000498289.1_Intron	NM_000655.4	NP_000646.2	P14151	LYAM1_HUMAN	selectin L	54	C-type lectin.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	15	all_hematologic(923;0.208)					GCAGAATCTTCTAGCCCTTTG	0.438000													9	15					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11651035	11651035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11651035G>A	ENST00000262442.3	+	32	6630	c.6562G>A	c.(6562-6564)Gat>Aat	p.D2188N	DNAH9_ENST00000454412.2_Missense_Mutation_p.D2188N	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2188	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGTCACAAATGATGAGCTCTT	0.522000													21	38					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108380669	108380669	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108380669G>A	ENST00000265843.4	-	6	5675	c.5565C>T	c.(5563-5565)ctC>ctT	p.L1855L	EXPH5_ENST00000428840.1_Silent_p.L1779L|EXPH5_ENST00000443411.1_Silent_p.L1667L|EXPH5_ENST00000525344.1_Silent_p.L1848L	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1855					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CACAGGAGGGGAGTTCAGAAA	0.448000													15	56					0	0	1	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77317640	77317640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77317640C>T	ENST00000558012.1	+	4	717	c.228C>T	c.(226-228)tcC>tcT	p.S76S	PSTPIP1_ENST00000379595.3_Silent_p.S76S|PSTPIP1_ENST00000559295.1_Silent_p.S76S|PSTPIP1_ENST00000267939.5_Silent_p.S75S	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	76	FCH.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						TGAGGGCCTCCTTTGACTCCT	0.617000													31	98					0	0	1	0	0
ZNF214	7761	broad.mit.edu	37	11	7022292	7022292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7022292C>T	ENST00000278314.4	-	3	937	c.622G>A	c.(622-624)Gac>Aac	p.D208N	ZNF214_ENST00000536068.1_Missense_Mutation_p.D208N	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		CTCAGTAGGTCTTCTTGACAT	0.388000													19	85					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61028342	61028342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61028342C>T	ENST00000373867.3	-	9	1129	c.664G>A	c.(664-666)Gaa>Aaa	p.E222K	FAM13C_ENST00000422313.2_Missense_Mutation_p.E305K|FAM13C_ENST00000435852.2_Missense_Mutation_p.E305K|FAM13C_ENST00000468840.2_Missense_Mutation_p.E222K|FAM13C_ENST00000442566.3_Missense_Mutation_p.E326K|FAM13C_ENST00000419214.2_Missense_Mutation_p.E305K|FAM13C_ENST00000373868.2_Missense_Mutation_p.E305K|FAM13C_ENST00000277705.6_Missense_Mutation_p.E326K	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	305										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TCAAATTTTTCTTCAAATTTC	0.493000													19	55					0	0	1	0	0
VWA1	64856	broad.mit.edu	37	1	1374575	1374575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1374575C>T	ENST00000476993.1	+	3	824	c.746C>T	c.(745-747)cCc>cTc	p.P249L	VWA1_ENST00000404702.3_Missense_Mutation_p.P37L|VWA1_ENST00000338660.5_3'UTR	NM_022834.4	NP_073745.2	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	249	Fibronectin type-III 1.					basement membrane				NS(1)|breast(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GAGCTGGTGCCCAGCGCCCAG	0.701000													3	25					0	0	1	0	0
WDR27	253769	broad.mit.edu	37	6	170068224	170068224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:170068224G>A	ENST00000333572.6	-	5	1033	c.514C>T	c.(514-516)Cca>Tca	p.P172S	WDR27_ENST00000423258.1_Intron|WDR27_ENST00000448612.1_Missense_Mutation_p.P172S|WDR27_ENST00000420344.2_Intron			A2RRH5	WDR27_HUMAN	WD repeat domain 27	152										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GTCGGTGGTGGGACTTTGTGG	0.517000													22	29					0	0	1	0	0
SP7	121340	broad.mit.edu	37	12	53723042	53723042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53723042C>T	ENST00000536324.2	-	3	467	c.184G>A	c.(184-186)Gat>Aat	p.D62N	SP7_ENST00000537210.2_Missense_Mutation_p.D44N|SP7_ENST00000303846.3_Missense_Mutation_p.D62N	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	62					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						GGATAAGCATCCCCCATGGTT	0.552000													44	139					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42510865	42510865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42510865C>T	ENST00000262895.3	-	15	1968	c.1969G>A	c.(1969-1971)Gac>Aac	p.D657N	GRIK5_ENST00000301218.4_Missense_Mutation_p.D657N|GRIK5_ENST00000593562.1_Missense_Mutation_p.D657N	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	657						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TCTGCCAGGTCATCGGCCGAC	0.617000													11	36					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230425	140230425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140230425C>T	ENST00000378122.3	+	1	3069	c.2345C>T	c.(2344-2346)tCt>tTt	p.S782F	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.S782F|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCTGGATCTACAGAGCGA	0.488000													45	42					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101348213	101348213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101348213G>A	ENST00000534062.1	-	1	2971	c.2913C>T	c.(2911-2913)gtC>gtT	p.V971V		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	971										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						AGAAGAAGAAGACCCAATGCC	0.552000													34	134					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8610561	8610561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8610561G>A	ENST00000338257.8	-	13	1596	c.1329C>T	c.(1327-1329)gtC>gtT	p.V443V		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	443	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GGTCACAGACGACCTTGTTGT	0.572000													71	321					0	0	1	0	0
MSANTD2	79684	broad.mit.edu	37	11	124637184	124637184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124637184G>A	ENST00000526629.1	-	3	2325	c.878C>T	c.(877-879)cCc>cTc	p.P293L	MSANTD2_ENST00000374979.3_Missense_Mutation_p.P523L|MSANTD2_ENST00000239614.4_Missense_Mutation_p.P471L			Q6P1R3	CK061_HUMAN	Myb/SANT-like DNA-binding domain containing 2	523																	GATGGATTTGGGGGAAACTCC	0.408000													45	105					0	0	1	0	0
DMC1	11144	broad.mit.edu	37	22	38962607	38962607	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38962607C>T	ENST00000216024.2	-	4	507	c.231G>A	c.(229-231)gcG>gcA	p.A77A	DMC1_ENST00000428462.2_Silent_p.A77A	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	77					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					TTAGTTTGTTCGCTGCCTCTT	0.378000								Homologous recombination					17	51					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107041010	107041010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107041010G>A	ENST00000409886.3	-	20	3500	c.3413C>T	c.(3412-3414)tCt>tTt	p.S1138F	RGPD3_ENST00000304514.7_Missense_Mutation_p.S1138F	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1138	RanBD1 1.				intracellular transport		binding	p.S1138Y(2)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						ATCACCATCAGAGAAATCACT	0.448000													84	127					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41327598	41327598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41327598G>A	ENST00000551295.2	+	9	1020	c.903G>A	c.(901-903)caG>caA	p.Q301Q	CNTN1_ENST00000547849.1_Silent_p.Q301Q|CNTN1_ENST00000547702.1_Silent_p.Q301Q|CNTN1_ENST00000348761.2_Silent_p.Q290Q|CNTN1_ENST00000360099.3_Silent_p.Q301Q|CNTN1_ENST00000347616.1_Silent_p.Q301Q	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	301	Ig-like C2-type 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TCAATATTCAGCTAGAAGATG	0.408000													19	68					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34487474	34487474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34487474C>T	ENST00000374012.3	+	10	1594	c.1465C>T	c.(1465-1467)Ccg>Tcg	p.P489S	PHF20_ENST00000439301.1_3'UTR|PHF20_ENST00000481202.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					AGAAGAGAGCCCGGGAAAGAG	0.512000													19	56					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32376538	32376538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32376538C>T	ENST00000298386.2	+	18	2332	c.2261C>T	c.(2260-2262)tCc>tTc	p.S754F	RXFP2_ENST00000380314.1_Missense_Mutation_p.S730F	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	754						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		AAACCAGTTTCCTAGCAATCA	0.403000													88	204					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27690811	27690811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27690811G>A	ENST00000374040.3	-	3	815	c.555C>T	c.(553-555)ggC>ggT	p.G185G	MAP3K6_ENST00000357582.2_Silent_p.G193G|MAP3K6_ENST00000493901.1_Silent_p.G193G			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	193					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CCCGCAGAAGGCCTGCATCAC	0.662000													33	94					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52382951	52382951	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52382951C>T	ENST00000420323.2	+	13	2415	c.2154C>T	c.(2152-2154)tcC>tcT	p.S718S		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	718	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGCTGGAGTCCGTGGGCCTTC	0.617000													37	96					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89156784	89156784	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89156784G>A	ENST00000452230.1	-	0	39				IGKC_ENST00000390237.2_RNA|AC096579.7_ENST00000430694.1_RNA																							ACCGCAATAGGGGTAGGTCCC	0.522000													4	14					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248437015	248437015	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248437015C>T	ENST00000318021.2	-	1	123	c.102G>A	c.(100-102)ttG>ttA	p.L34L		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACAGGGAGGTCAAAACGATAC	0.493000													24	90					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481976	123481976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123481976G>A	ENST00000280562.5	-	10	1573	c.1368C>T	c.(1366-1368)ttC>ttT	p.F456F	PITPNM2_ENST00000320201.4_Silent_p.F456F|PITPNM2_ENST00000392428.1_Silent_p.F177F|PITPNM2_ENST00000542749.1_Silent_p.F456F			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	456					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGACGGTGTCGAACACGTTGG	0.672000													33	86					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118629401	118629401	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:118629401G>A	ENST00000336338.5	-	12	1569	c.1504C>T	c.(1504-1506)Cat>Tat	p.H502Y		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	502						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AATATGTCATGAAGATTCTAT	0.388000													35	88					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30971164	30971164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:30971164C>T	ENST00000399914.1	-	8	1713	c.1192G>A	c.(1192-1194)Gaa>Aaa	p.E398K	GRIK1_ENST00000399907.1_Missense_Mutation_p.E398K|GRIK1_ENST00000399913.1_Missense_Mutation_p.E398K|GRIK1_ENST00000389125.3_Missense_Mutation_p.E398K|GRIK1-AS2_ENST00000333765.4_Intron|GRIK1_ENST00000399909.1_Missense_Mutation_p.E398K|GRIK1_ENST00000327783.4_Missense_Mutation_p.E398K|BACH1_ENST00000462262.1_Intron|GRIK1_ENST00000535441.1_Missense_Mutation_p.E400K|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000389124.2_Missense_Mutation_p.E398K|GRIK1_ENST00000309434.7_Missense_Mutation_p.E400K			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	398					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TCAGTTCCTTCCTCTTTGAGA	0.368000													32	84					0	0	1	0	0
SCN2B	6327	broad.mit.edu	37	11	118037788	118037788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118037788C>T	ENST00000278947.5	-	4	703	c.462G>A	c.(460-462)cgG>cgA	p.R154R		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	154	Ig-like C2-type.				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		CCGTGGAGTCCCGCTCAGGGG	0.617000													21	48					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10554890	10554890	+	Silent	SNP	G	G	A	rs148322984		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10554890G>A	ENST00000583535.1	-	5	531	c.444C>T	c.(442-444)cgC>cgT	p.R148R	MYH3_ENST00000226209.7_Silent_p.R148R	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	148	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GGGCCTCCTGGCGCTTTTTGC	0.577000													95	113					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8807901	8807901	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8807901C>T	ENST00000324436.3	-	1	1271	c.1151G>A	c.(1150-1152)gGc>gAc	p.G384D		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	384						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						CAGGATGGAGCCCCCGATCCA	0.647000													14	44					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111962889	111962889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111962889G>A	ENST00000305815.5	-	11	1484	c.1232C>T	c.(1231-1233)aCc>aTc	p.T411I	SLC9C1_ENST00000487372.1_Missense_Mutation_p.T363I	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	411					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										GACAACAAGGGTTATTAGGCA	0.308000													18	65					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60637186	60637186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60637186C>T	ENST00000278853.5	+	3	495	c.495C>T	c.(493-495)ctC>ctT	p.L165L		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	165					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						TTTCCTTCCTCCCCACCTCTG	0.617000													16	33					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79059007	79059007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79059007C>T	ENST00000388820.4	-	19	3456	c.3246G>A	c.(3244-3246)gaG>gaA	p.E1082E		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1082					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GATCGGGCTCCTCAGAGGGCC	0.632000													7	51					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94740655	94740655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94740655G>A	ENST00000289495.5	+	2	1696	c.1480G>A	c.(1480-1482)Gaa>Aaa	p.E494K	PPP1R9A_ENST00000424654.1_Missense_Mutation_p.E494K|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.E494K|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.E494K|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.E494K|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.E494K	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	494	Interacts with protein phosphatase 1 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GTATGAACTTGAAAAACGTGT	0.403000										HNSCC(28;0.073)			18	45					0	0	1	0	0
ZNF384	171017	broad.mit.edu	37	12	6781694	6781694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6781694G>A	ENST00000396801.3	-	8	1123	c.916C>T	c.(916-918)Cac>Tac	p.H306Y	ZNF384_ENST00000355772.4_Intron|ZNF384_ENST00000361959.3_Missense_Mutation_p.H306Y|ZNF384_ENST00000396795.1_Intron|ZNF384_ENST00000319770.3_Intron|ZNF384_ENST00000396799.2_Intron	NM_001135734.2	NP_001129206.1	Q8TF68	ZN384_HUMAN	zinc finger protein 384	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						ATCTTGGAGTGGATCCTGCCG	0.607000			T	"""EWSR1, TAF15 """	ALL								14	31					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31864570	31864570	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31864570G>A	ENST00000396184.3	-	14	1521	c.1317C>T	c.(1315-1317)ttC>ttT	p.F439F	PDE1C_ENST00000396191.1_Silent_p.F439F|PDE1C_ENST00000321453.7_Silent_p.F439F|PDE1C_ENST00000396193.1_Silent_p.F499F|PDE1C_ENST00000396182.2_Silent_p.F439F	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	439	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			TAAGCACAGTGAAGGTGGGTT	0.473000													49	95					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157514069	157514069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157514069G>A	ENST00000361835.3	-	5	984	c.827C>T	c.(826-828)tCc>tTc	p.S276F	FCRL5_ENST00000368189.3_Missense_Mutation_p.S276F|FCRL5_ENST00000368190.3_Missense_Mutation_p.S276F|FCRL5_ENST00000356953.4_Missense_Mutation_p.S276F|FCRL5_ENST00000368191.3_Missense_Mutation_p.S191F	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	276						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CTGTATCCAGGATCTCGGGCT	0.507000													26	155					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128342409	128342409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128342409C>T	ENST00000389524.4	+	14	1664	c.1611C>T	c.(1609-1611)gcC>gcT	p.A537A	MYO7B_ENST00000428314.1_Silent_p.A537A|MYO7B_ENST00000409816.2_Silent_p.A537A			Q6PIF6	MYO7B_HUMAN	myosin VIIB	537	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACAACAAGGCCTTCCTACAGC	0.557000													23	110					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50090851	50090851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50090851C>T	ENST00000281631.5	+	12	1186	c.1028C>T	c.(1027-1029)tCc>tTc	p.S343F	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505554.1_Missense_Mutation_p.S322F|PARP8_ENST00000503750.2_Missense_Mutation_p.S343F|PARP8_ENST00000514342.2_Missense_Mutation_p.S96F|PARP8_ENST00000505697.2_Missense_Mutation_p.S343F|PARP8_ENST00000514067.2_Missense_Mutation_p.S343F	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	343						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				TTTGGCCGCTCCTTGTCCAGC	0.517000													29	85					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8417209	8417209	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8417209G>A	ENST00000360416.3	-	22	2646	c.2508C>T	c.(2506-2508)gcC>gcT	p.A836A	MYH10_ENST00000396239.1_Silent_p.A826A|MYH10_ENST00000269243.4_Silent_p.A805A|MYH10_ENST00000379980.4_Silent_p.A821A	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	805					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TCTTGGCAAAGGCCCTGAAGA	0.453000													5	12					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65325929	65325929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:65325929G>A	ENST00000342505.4	-	9	1441	c.1193C>T	c.(1192-1194)tCc>tTc	p.S398F		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	398	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		CTCCTCGTGGGAAGAGAGCTT	0.542000			Mis		ALL								18	52					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6055729	6055729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6055729G>A	ENST00000282924.5	-	13	2339	c.1854C>T	c.(1852-1854)ctC>ctT	p.L618L	JAKMIP1_ENST00000410077.2_Silent_p.L453L|JAKMIP1_ENST00000409831.1_Silent_p.L618L|JAKMIP1_ENST00000409021.3_Intron|JAKMIP1_ENST00000409371.3_Intron	NM_144720.3	NP_653321.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	618	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TGGGTTCAAAGAGAATGTCTG	0.373000													44	147					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92532058	92532058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92532058G>A	ENST00000298047.6	+	9	5896	c.5879G>A	c.(5878-5880)gGa>gAa	p.G1960E	FAT3_ENST00000525166.1_Missense_Mutation_p.G1810E|FAT3_ENST00000409404.2_Missense_Mutation_p.G1960E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1960	Cadherin 17.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGTCTGATGGAAAGTTCTAC	0.413000										TCGA Ovarian(4;0.039)			45	79					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2983188	2983188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2983188G>A	ENST00000342628.2	-	2	570	c.457C>T	c.(457-459)Cct>Tct	p.P153S	FOXM1_ENST00000361953.3_Missense_Mutation_p.P153S|FOXM1_ENST00000359843.3_Missense_Mutation_p.P153S|FOXM1_ENST00000537018.1_5'UTR	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	153					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GGTGGTCTAGGAAGATTCACA	0.557000													16	123					0	0	1	0	0
RAC2	5880	broad.mit.edu	37	22	37627425	37627425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37627425G>A	ENST00000249071.6	-	5	415	c.294C>T	c.(292-294)ttC>ttT	p.F98F	RAC2_ENST00000405484.1_Silent_p.F91F|RAC2_ENST00000406508.1_Silent_p.F54F	NM_002872.3	NP_002863.1	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	98					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)	12						GCACTTCTGGGAACCACTGGG	0.627000													21	51					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89346988	89346988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89346988G>A	ENST00000301030.4	-	9	6422	c.5962C>T	c.(5962-5964)Ccc>Tcc	p.P1988S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1988S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1988	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGGGACTCGGGGAATCTCTGT	0.692000													5	57					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064667	9064667	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9064667G>A	ENST00000397910.4	-	3	22982	c.22779C>T	c.(22777-22779)tcC>tcT	p.S7593S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7595	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGACATTGTGGACTGCTCAG	0.488000													35	80					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232561550	232561550	+	Missense_Mutation	SNP	G	G	A	rs150962063		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:232561550G>A	ENST00000366630.1	-	17	4773	c.4415C>T	c.(4414-4416)tCg>tTg	p.S1472L	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.S1472L|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.S546L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1472					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity	p.S1472L(1)		NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCCATAGAACGAAAACTAGGG	0.507000													7	26					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116429583	116429583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:116429583G>A	ENST00000281928.3	-	17	3382	c.3176C>T	c.(3175-3177)aCt>aTt	p.T1059I		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1059					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		ACCTCTGGGAGTTCTTGGGGT	0.612000													24	75					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43623872	43623872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43623872C>T	ENST00000372806.3	+	6	762	c.667C>T	c.(667-669)Cct>Tct	p.P223S	STK4_ENST00000499879.2_Missense_Mutation_p.P168S|STK4_ENST00000372801.1_Missense_Mutation_p.P223S|STK4_ENST00000396731.4_Missense_Mutation_p.P223S	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	223	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				AGGAAAGCCCCCTTATGCTGA	0.448000													22	68					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9391729	9391729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9391729C>T	ENST00000378501.2	+	21	2024	c.2009C>T	c.(2008-2010)tCg>tTg	p.S670L	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.S682L|PLCB4_ENST00000278655.4_Missense_Mutation_p.S670L|PLCB4_ENST00000378493.1_Missense_Mutation_p.S670L|PLCB4_ENST00000334005.3_Missense_Mutation_p.S670L|PLCB4_ENST00000378473.3_Missense_Mutation_p.S682L	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	670	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity	p.S670L(1)		NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TATAATGGATCGTGCGGGTGA	0.363000													33	58					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349739	100349739	+	RNA	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100349739T>A	ENST00000542585.1	+	0	2159				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GACCACCACCTCCATGGAAGA	0.522000													25	68					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20387405	20387405	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20387405G>A	ENST00000302451.4	-	4	776	c.528C>T	c.(526-528)atC>atT	p.I176I		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	176					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						AGAAGCCAACGATGACCAAGG	0.522000													15	45					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67691229	67691229	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:67691229C>T	ENST00000545606.1	+	5	971	c.534C>T	c.(532-534)acC>acT	p.T178T		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	178					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		CAATTCTGACCTGTCTACTTC	0.393000													74	176					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73447448	73447448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73447448C>T	ENST00000224721.6	+	18	2051	c.2046C>T	c.(2044-2046)ttC>ttT	p.F682F	CDH23_ENST00000299366.7_Silent_p.F722F	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	677	Cadherin 7.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CCGCCTACTTCGTCTCCGTGG	0.627000													21	17					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3155824	3155824	+	Silent	SNP	C	C	T	rs140382547		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3155824C>T	ENST00000262958.3	+	5	876	c.618C>T	c.(616-618)atC>atT	p.I206I		NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	206					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		CCTGTAGGATCGTGGACGTCG	0.557000													19	46					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857197	9857197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9857197G>A	ENST00000396573.2	-	14	4513	c.4204C>T	c.(4204-4206)Cgg>Tgg	p.R1402W	GRIN2A_ENST00000535259.1_3'UTR|GRIN2A_ENST00000404927.2_3'UTR|GRIN2A_ENST00000562109.1_3'UTR|GRIN2A_ENST00000330684.3_Missense_Mutation_p.R1402W|GRIN2A_ENST00000396575.2_Missense_Mutation_p.R1402W	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1402					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.R1402W(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAGGACGACCGAAGATAGCTG	0.522000													17	65					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112758801	112758801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:112758801C>T	ENST00000295408.4	+	11	1885	c.1628C>T	c.(1627-1629)tCt>tTt	p.S543F	MERTK_ENST00000409780.1_Missense_Mutation_p.S367F|MERTK_ENST00000421804.2_Missense_Mutation_p.S543F			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	543					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						GAGGAGGATTCTGAATTAGTG	0.403000													33	51					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7531715	7531715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7531715G>A	ENST00000313599.3	-	9	2287	c.2230C>T	c.(2230-2232)Cat>Tat	p.H744Y	CD163L1_ENST00000544331.1_Intron|CD163L1_ENST00000396630.1_Missense_Mutation_p.H744Y|CD163L1_ENST00000416109.2_Missense_Mutation_p.H754Y			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	744	SRCR 7.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TCTGTGAAATGAGGCTCTCTG	0.478000													29	121					0	0	1	0	0
KCNK15	60598	broad.mit.edu	37	20	43378995	43378995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43378995C>T	ENST00000372861.3	+	2	640	c.509C>T	c.(508-510)aCc>aTc	p.T170I		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	170						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				TGTGCCGCCACCCTGGCCCTC	0.687000													12	18					0	0	1	0	0
CLIP4	79745	broad.mit.edu	37	2	29354130	29354130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29354130C>T	ENST00000320081.5	+	3	395	c.140C>T	c.(139-141)tCt>tTt	p.S47F	CLIP4_ENST00000401617.2_5'UTR|CLIP4_ENST00000401605.1_Missense_Mutation_p.S47F|CLIP4_ENST00000404424.1_Missense_Mutation_p.S47F	NM_024692.4	NP_078968.3	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family, member 4	47										endometrium(4)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(1)	26	Acute lymphoblastic leukemia(172;0.155)					TCAGAATTTTCTTTCTTTGAT	0.274000													16	36					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47463690	47463690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47463690C>T	ENST00000285039.7	-	15	2129	c.1830G>A	c.(1828-1830)tcG>tcA	p.S610S		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	610	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CGCTGATCTTCGAAGATGACC	0.532000													25	72					0	0	1	0	0
SERPINB5	5268	broad.mit.edu	37	18	61154191	61154191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61154191G>A	ENST00000382771.4	+	3	473	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	SERPINB5_ENST00000489441.1_Missense_Mutation_p.E61K	NM_002639.4	NP_002630.2	P36952	SPB5_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 5	61					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						TCTTCATTTTGAAAATGTCAA	0.388000													34	79					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33195256	33195256	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:33195256C>T	ENST00000242067.6	+	4	791	c.270C>T	c.(268-270)acC>acT	p.T90T	BBS9_ENST00000396127.2_Silent_p.T90T|BBS9_ENST00000354265.4_Silent_p.T90T|BBS9_ENST00000425508.2_Silent_p.T45T|BBS9_ENST00000355070.2_Silent_p.T90T|BBS9_ENST00000350941.3_Silent_p.T90T	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	90					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			TCAGAGGTACCGAAATGCTAC	0.289000									Bardet-Biedl syndrome				9	32					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97329689	97329689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97329689C>T	ENST00000389672.5	+	13	2603	c.2565C>T	c.(2563-2565)tcC>tcT	p.S855S	EPHA6_ENST00000514100.1_Silent_p.S247S|EPHA6_ENST00000502694.1_Silent_p.S247S|EPHA6_ENST00000442602.2_Silent_p.S221S	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	760	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CCCTAGACTCCTTTTTGCGGG	0.333000													22	61					0	0	1	0	0
CYP26B1	56603	broad.mit.edu	37	2	72360181	72360181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:72360181G>A	ENST00000001146.2	-	5	1320	c.1117C>T	c.(1117-1119)Cgc>Tgc	p.R373C	CYP26B1_ENST00000412253.1_Missense_Mutation_p.R182C|CYP26B1_ENST00000546307.1_Missense_Mutation_p.R298C	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	373					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						AGCACAGTGCGGTAGCCGCCG	0.682000													21	54					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39436236	39436236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39436236G>A	ENST00000257408.4	+	2	1329	c.1232G>A	c.(1231-1233)cGa>cAa	p.R411Q		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	411	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						AACAACCCTCGAATCTTGATT	0.428000													41	111					0	0	1	0	0
ARSG	22901	broad.mit.edu	37	17	66339821	66339821	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66339821C>T	ENST00000448504.2	+	3	1091	c.295C>T	c.(295-297)Cgc>Tgc	p.R99C	ARSG_ENST00000452479.2_5'UTR	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	99					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GCTTGGCCTTCGCAATGGAGT	0.607000													17	53					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78212139	78212139	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78212139C>T	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TCTTCTCTTCCTTTAATGTTC	0.552000													57	364					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807307	143807307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143807307C>T	ENST00000408979.2	+	1	701	c.632C>T	c.(631-633)tCc>tTc	p.S211F		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					GGGCCTCTTTCCTTGATTCTG	0.527000													61	169					0	0	1	0	0
C11orf65	160140	broad.mit.edu	37	11	108256664	108256664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108256664G>A	ENST00000525729.1	-	6	692	c.623C>T	c.(622-624)tCt>tTt	p.S208F	C11orf65_ENST00000393084.1_Missense_Mutation_p.S257F|C11orf65_ENST00000529391.1_Missense_Mutation_p.S257F|C11orf65_ENST00000526725.1_Intron			Q8NCR3	CK065_HUMAN	chromosome 11 open reading frame 65	257										endometrium(1)|large_intestine(3)|lung(4)|ovary(2)	10		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		GTTAGCCGAAGAGTTGCTTGT	0.338000													17	215					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21122984	21122984	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21122984G>A	ENST00000261383.3	-	14	2061	c.2062C>T	c.(2062-2064)Caa>Taa	p.Q688*	DNAH3_ENST00000415178.1_Nonsense_Mutation_p.Q688*	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	688	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACTTGGAATTGAATCAGATGG	0.433000													27	95					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94519661	94519661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:94519661C>T	ENST00000375708.3	-	3	554	c.356G>A	c.(355-357)cGa>cAa	p.R119Q	ROR2_ENST00000375715.1_5'UTR|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	119	Ig-like C2-type.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GATTCGCAGTCGTGAACCATA	0.587000													39	136					0	0	1	0	0
SPINK4	27290	broad.mit.edu	37	9	33248459	33248459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33248459G>A	ENST00000379725.1	+	5	442	c.320G>A	c.(319-321)gGc>gAc	p.G107D	SPINK4_ENST00000379723.1_Missense_Mutation_p.G107D|SPINK4_ENST00000379721.3_Missense_Mutation_p.G84D			O60575	ISK4_HUMAN	serine peptidase inhibitor, Kazal type 4	84						extracellular region	serine-type endopeptidase inhibitor activity			lung(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			ATGAAAGATGGCAAATGCTGA	0.483000													13	25					0	0	1	0	0
OASL	8638	broad.mit.edu	37	12	121458439	121458439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121458439C>T	ENST00000257570.5	-	6	1740	c.1470G>A	c.(1468-1470)ggG>ggA	p.G490G	OASL_ENST00000339275.5_3'UTR	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	490	Ubiquitin-like 2.				interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGCCATAGATCCCCAGACCCA	0.517000													22	51					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77642739	77642739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:77642739G>A	ENST00000407578.2	-	70	12398	c.12132C>T	c.(12130-12132)ttC>ttT	p.F4044F	MYCBP2_ENST00000357337.6_Silent_p.F4006F|MYCBP2_ENST00000544440.2_Silent_p.F4006F	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4006					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GAAGCAGCGAGAAGAGATCCT	0.473000													10	28					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604650	179604650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179604650C>T	ENST00000589042.1	-	48	13534	c.13310G>A	c.(13309-13311)aGa>aAa	p.R4437K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R4120K|TTN_ENST00000342175.6_Missense_Mutation_p.R4266K|TTN_ENST00000359218.5_Missense_Mutation_p.R4199K|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R4074K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4120	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATGATGTGTCTGGGCTCTTG	0.458000													33	112					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760970	62760970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62760970C>T	ENST00000336232.2	-	10	1590	c.1455G>A	c.(1453-1455)ggG>ggA	p.G485G	SLC22A8_ENST00000311438.8_Silent_p.G485G|SLC22A8_ENST00000545207.1_Silent_p.G394G|SLC22A8_ENST00000535878.1_Silent_p.G362G|SLC22A8_ENST00000430500.2_Silent_p.G485G	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	485					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CAGCACTGCCCCCGAGGAGGG	0.597000													15	120					0	0	1	0	0
HTR3D	200909	broad.mit.edu	37	3	183756207	183756207	+	Silent	SNP	C	C	T	rs139778852		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183756207C>T	ENST00000382489.3	+	7	930	c.930C>T	c.(928-930)ttC>ttT	p.F310F	HTR3D_ENST00000428798.2_Silent_p.F260F|HTR3D_ENST00000334128.2_Silent_p.F135F|HTR3D_ENST00000453435.1_Silent_p.F89F	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	310						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GTGTCTACTTCGCCCTGTGCC	0.587000													29	77					0	0	1	0	0
SIT1	27240	broad.mit.edu	37	9	35650207	35650207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35650207C>T	ENST00000259608.3	-	4	417	c.331G>A	c.(331-333)Gat>Aat	p.D111N	SIT1_ENST00000474403.1_5'UTR	NM_014450.2	NP_055265.1	Q9Y3P8	SIT1_HUMAN	signaling threshold regulating transmembrane adaptor 1	111					regulation of T cell activation|signal transduction	integral to plasma membrane	kinase binding|SH2 domain binding			endometrium(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	9			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGAGTTGGATCCTGCTGGTCT	0.617000													21	45					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540263	133540263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133540263G>A	ENST00000409261.1	-	14	4494	c.4121C>T	c.(4120-4122)cCa>cTa	p.P1374L	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.P1374L	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1374							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTCAGACTTTGGAGGGATCCT	0.617000													24	50					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51412231	51412231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:51412231G>A	ENST00000319760.6	-	1	217	c.165C>T	c.(163-165)tcC>tcT	p.S55S		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	55				GSP -> CSA (in Ref. 1; BAC05754).	sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				AATACATTGGGGAACCCAAGG	0.403000													18	55					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71092118	71092118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71092118C>T	ENST00000283228.2	-	8	1658	c.1206G>A	c.(1204-1206)atG>atA	p.M402I	PTPRR_ENST00000549308.1_Missense_Mutation_p.M157I|PTPRR_ENST00000440835.2_Missense_Mutation_p.M157I|PTPRR_ENST00000342084.4_Missense_Mutation_p.M290I|PTPRR_ENST00000378778.1_Missense_Mutation_p.M196I	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	402	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CCACAAAGTTCATTGGTATTT	0.338000													19	56					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57423014	57423014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57423014G>A	ENST00000442789.2	-	28	3194	c.2907C>T	c.(2905-2907)ttC>ttT	p.F969F	MYO1A_ENST00000544473.1_Silent_p.F807F|MYO1A_ENST00000300119.3_Silent_p.F969F	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	969					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TGACCAGCAGGAAGTCCCCCT	0.512000													33	68					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	14066290	14066290	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:14066290C>T	ENST00000217246.4	+	3	582	c.187C>T	c.(187-189)Cag>Tag	p.Q63*	MACROD2_ENST00000310348.4_Nonsense_Mutation_p.Q63*	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	63	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				GGAAACATCCCAGGTGAAGAA	0.303000													19	61					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42683086	42683086	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42683086C>T	ENST00000358131.5	+	5	1034	c.826C>T	c.(826-828)Cag>Tag	p.Q276*	TOX2_ENST00000435864.2_Nonsense_Mutation_p.Q145*|TOX2_ENST00000341197.3_Nonsense_Mutation_p.Q267*|TOX2_ENST00000423191.1_Nonsense_Mutation_p.Q225*|TOX2_ENST00000372999.1_Nonsense_Mutation_p.Q225*	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CATCAAGGGTCAGAACCCCAG	0.562000													8	57					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497619	1497619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1497619C>T	ENST00000421627.2	+	2	894	c.760C>T	c.(760-762)Ccc>Tcc	p.P254S		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	333					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GCTGCAGAGCCCCTTCGGGGA	0.662000													14	112					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735502	140735502	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140735502C>T	ENST00000571252.1	+	1	735	c.735C>T	c.(733-735)ccC>ccT	p.P245P	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCACTCAGCCCGAGTACCACG	0.532000													15	26					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307236	14307236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:14307236G>A	ENST00000378053.3	-	2	1173	c.917C>T	c.(916-918)cCc>cTc	p.P306L	FLRT3_ENST00000341420.4_Missense_Mutation_p.P306L|MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	306	LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GCAATACCAGGGATTGTTGCG	0.438000													37	77					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98408551	98408551	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98408551G>A	ENST00000339364.5	-	7	1169	c.1050C>T	c.(1048-1050)aaC>aaT	p.N350N	PIK3AP1_ENST00000468783.1_5'UTR|PIK3AP1_ENST00000371110.2_Silent_p.N172N	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	350						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		AGGCAGTGAGGTTCTTCAGTC	0.507000													10	38					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16910772	16910772	+	Missense_Mutation	SNP	C	C	T	rs140495987		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16910772C>T	ENST00000524140.2	+	17	3953	c.3535C>T	c.(3535-3537)Cgc>Tgc	p.R1179C	NWD1_ENST00000523826.1_Missense_Mutation_p.R973C|NWD1_ENST00000379808.3_Missense_Mutation_p.R1179C|NWD1_ENST00000552788.1_Missense_Mutation_p.R1179C|NWD1_ENST00000339803.6_Missense_Mutation_p.R1044C|NWD1_ENST00000549814.1_Intron	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1179							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CCTGCTGGCCCGCGGCGGGGC	0.622000													17	63					0	0	1	0	0
SPATA19	219938	broad.mit.edu	37	11	133714162	133714162	+	Missense_Mutation	SNP	C	C	T	rs138223153		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:133714162C>T	ENST00000299140.3	-	4	392	c.338G>A	c.(337-339)cGa>cAa	p.R113Q	SPATA19_ENST00000532889.1_Missense_Mutation_p.R113Q	NM_174927.1	NP_777587.1	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19	113					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane				cervix(1)|endometrium(2)|large_intestine(2)|lung(5)|prostate(1)	11	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GAACTGGATTCGTGTTCTCTC	0.537000													30	95					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71796724	71796724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:71796724G>A	ENST00000269500.5	-	5	808	c.473C>T	c.(472-474)cCa>cTa	p.P158L	FBXO15_ENST00000419743.2_Missense_Mutation_p.P234L	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	158										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		TGCTAGGCATGGCCATTTTTT	0.373000													15	37					0	0	1	0	0
KLHL24	54800	broad.mit.edu	37	3	183381334	183381334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183381334C>T	ENST00000454652.1	+	5	1395	c.1009C>T	c.(1009-1011)Cct>Tct	p.P337S	KLHL24_ENST00000242810.6_Missense_Mutation_p.P337S|KLHL24_ENST00000476808.1_Missense_Mutation_p.P337S			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	337						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GTGCTACGATCCTGTAACAGG	0.413000													41	121					0	0	1	0	0
TNNT3	7140	broad.mit.edu	37	11	1955049	1955049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1955049C>T	ENST00000381558.1	+	9	525	c.246C>T	c.(244-246)gtC>gtT	p.V82V	TNNT3_ENST00000360603.3_Silent_p.V84V|TNNT3_ENST00000381549.3_Silent_p.V82V|TNNT3_ENST00000381579.3_Silent_p.V82V|TNNT3_ENST00000446240.1_Silent_p.V71V|TNNT3_ENST00000397301.1_Silent_p.V101V|TNNT3_ENST00000278317.6_Silent_p.V90V|TNNT3_ENST00000397304.2_Silent_p.V71V|TNNT3_ENST00000381589.3_Silent_p.V88V|TNNT3_ENST00000381561.4_Silent_p.V93V|TNNT3_ENST00000381548.3_Silent_p.V92V			P45378	TNNT3_HUMAN	troponin T type 3 (skeletal, fast)	101					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(4)|stomach(1)	19		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		AGGAGCTGGTCGCTCTCAAAG	0.597000													18	68					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911199	230911199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230911199C>T	ENST00000295190.4	-	4	1101	c.643G>A	c.(643-645)Ggt>Agt	p.G215S		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	215						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		GGGTTTTTACCAGGAGAGAGG	0.552000													43	81					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577796	9577796	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9577796G>A	ENST00000301480.4	-	10	2040	c.1827C>T	c.(1825-1827)ttC>ttT	p.F609F		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	609					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						AGCGTTCTGTGAAGGCTTTTC	0.423000													47	143					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56480866	56480866	+	Missense_Mutation	SNP	G	G	A	rs140472004		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56480866G>A	ENST00000370765.6	-	24	7506	c.7399C>T	c.(7399-7401)Cgt>Tgt	p.R2467C	DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000244364.6_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1763					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AAATTTCTACGGGAGGCTTTT	0.493000													13	136					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123249380	123249380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123249380C>T	ENST00000264501.4	+	66	11490	c.11117C>T	c.(11116-11118)tCa>tTa	p.S3706L	KIAA1109_ENST00000388738.3_Missense_Mutation_p.S3706L			Q2LD37	K1109_HUMAN	KIAA1109	3706					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GGAGGCTTTTCACCAGGCATT	0.443000													48	107					0	0	1	0	0
OR6C74	254783	broad.mit.edu	37	12	55641666	55641666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55641666C>T	ENST00000343870.4	+	1	685	c.595C>T	c.(595-597)Ctc>Ttc	p.L199F		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						AATGATGCTTCTCTCAGCCAT	0.393000													26	74					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14533190	14533190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14533190G>A	ENST00000358970.5	-	5	924	c.925C>T	c.(925-927)Ctc>Ttc	p.L309F	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	309										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GCAAGTATGAGGGCAGTTCTA	0.343000													28	97					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934842	113934842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113934842G>A	ENST00000335953.4	+	2	1200	c.820G>A	c.(820-822)Gaa>Aaa	p.E274K	ZBTB16_ENST00000392996.2_Missense_Mutation_p.E274K	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	274					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding	p.E274*(1)		central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CAAGGTTGAGGAAAGAGGCAA	0.627000													19	31					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48685383	48685383	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48685383G>A	ENST00000544264.1	-	21	7315	c.7035C>T	c.(7033-7035)gcC>gcT	p.A2345A	CELSR3_ENST00000164024.4_Silent_p.A2340A			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2340					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTAGCGACGGGCCCCCCGGG	0.632000													43	150					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221131	161221131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161221131C>T	ENST00000327928.4	+	4	835	c.835C>T	c.(835-837)Cgt>Tgt	p.R279C		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	279	Collagen-like 3.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						CAAAAGCGGCCGTAATGGTCT	0.537000													6	8					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74825080	74825080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74825080C>T	ENST00000256362.4	+	2	1835	c.1594C>T	c.(1594-1596)Cgc>Tgc	p.R532C		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	532					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CTTCCGCCTCCGCTACCCCAG	0.647000													52	148					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61463559	61463559	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61463559G>A	ENST00000398019.2	+	5	721	c.396G>A	c.(394-396)acG>acA	p.T132T	SERPINB7_ENST00000336429.2_Silent_p.T132T|SERPINB7_ENST00000546027.1_Silent_p.T132T|SERPINB7_ENST00000540675.1_Silent_p.T115T	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	132					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity	p.T132T(1)		central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				TTGACTTTACGAATCATTTAG	0.333000													21	62					0	0	1	0	0
GPATCH2L	55668	broad.mit.edu	37	14	76647109	76647109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76647109C>T	ENST00000261530.7	+	8	1176	c.1110C>T	c.(1108-1110)ttC>ttT	p.F370F	GPATCH2L_ENST00000312858.5_Silent_p.F365F	NM_017926.2	NP_060396.2			G patch domain containing 2-like																		TCCTGCAGTTCAATCCCCTGT	0.438000													22	217					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48451736	48451736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48451736G>A	ENST00000358536.4	-	31	5843	c.5574C>T	c.(5572-5574)ctC>ctT	p.L1858L	PLXNB1_ENST00000296440.6_Silent_p.L1858L|PLXNB1_ENST00000358459.4_Silent_p.L1675L|PLXNB1_ENST00000456774.1_Silent_p.L1675L|PLXNB1_ENST00000448774.2_Silent_p.L469L	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1858					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTTTTCCCGGAGCACATGCT	0.632000													9	37					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458559	45458559	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45458559G>A	ENST00000548424.1	+	0	448																											AGGTCCAGAGGGACCATCAAC	0.473000													15	38					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50682527	50682527	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50682527G>A	ENST00000403097.1	-	11	1797	c.1017C>T	c.(1015-1017)ttC>ttT	p.F339F	GRB10_ENST00000402497.1_Silent_p.F287F|GRB10_ENST00000439599.1_Silent_p.F339F|GRB10_ENST00000398812.2_Silent_p.F345F|GRB10_ENST00000401949.1_Silent_p.F345F|GRB10_ENST00000407526.1_Silent_p.F287F|GRB10_ENST00000402578.1_Silent_p.F287F|GRB10_ENST00000335866.3_Silent_p.F287F|GRB10_ENST00000398810.2_Silent_p.F287F|GRB10_ENST00000357271.5_Silent_p.F299F|GRB10_ENST00000406641.1_Silent_p.F287F			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	345	PH.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CGATCAGGGAGAAGATGTTGC	0.572000									Russell-Silver syndrome				27	113					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156785878	156785878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156785878C>T	ENST00000392306.2	-	2	182	c.43G>A	c.(43-45)Gaa>Aaa	p.E15K	NTRK1_ENST00000392302.2_Intron|SH2D2A_ENST00000368199.3_Missense_Mutation_p.E15K|SH2D2A_ENST00000495306.1_5'UTR|SH2D2A_ENST00000368198.3_Intron	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	15					angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ATGGGGGCTTCGTGACTCCCT	0.612000													4	29					0	0	1	0	0
UBQLN4	56893	broad.mit.edu	37	1	156018388	156018388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156018388G>A	ENST00000368309.3	-	5	896	c.804C>T	c.(802-804)gcC>gcT	p.A268A	UBQLN4_ENST00000472638.1_5'UTR|UBQLN4_ENST00000368307.1_Intron	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	268						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					GGTTGCTCAGGGCCCGGTCCT	0.582000													28	52					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881311	228881311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228881311G>A	ENST00000392056.3	-	7	4305	c.4259C>T	c.(4258-4260)tCa>tTa	p.S1420L	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S1420L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1420						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CGAGCAAAGTGATCGCCTTTT	0.458000													52	106					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26694975	26694975	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26694975C>T	ENST00000529632.2	+	5	1384	c.1188C>T	c.(1186-1188)ccC>ccT	p.P396P	SEZ6L_ENST00000360929.3_Silent_p.P396P|SEZ6L_ENST00000402979.1_Silent_p.P169P|SEZ6L_ENST00000404234.3_Silent_p.P396P|SEZ6L_ENST00000343706.4_Silent_p.P396P|SEZ6L_ENST00000403121.1_Silent_p.P169P|SEZ6L_ENST00000248933.6_Silent_p.P396P	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	396	Sushi 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GCAACTTTCCCCGCCGGCCTG	0.587000													20	49					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813469	106813469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106813469C>T	ENST00000407775.2	+	8	1409	c.1159C>T	c.(1159-1161)Cct>Tct	p.P387S	ZFPM2_ENST00000520492.1_Missense_Mutation_p.P255S|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.P118S|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.P255S|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	387					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GCTCCATGTCCCTAGCGGCAA	0.512000													60	95					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45817476	45817476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45817476G>A	ENST00000358525.4	-	4	474	c.359C>T	c.(358-360)cCc>cTc	p.P120L	SLC6A20_ENST00000353278.4_Missense_Mutation_p.P120L|SLC6A20_ENST00000456124.2_Missense_Mutation_p.P120L	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	120					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CCACGGCAGGGGATCCTGTGG	0.582000													33	60					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71532629	71532629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71532629G>A	ENST00000265382.3	+	9	1242	c.937G>A	c.(937-939)Ggt>Agt	p.G313S	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.G313S	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	313	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		ATCTATCCAGGGTCCAGGGAA	0.527000													24	94					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996099	140996099	+	Missense_Mutation	SNP	C	C	T	rs143297640		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140996099C>T	ENST00000285879.4	+	4	3195	c.2909C>T	c.(2908-2910)cCt>cTt	p.P970L	MAGEC1_ENST00000406005.2_Missense_Mutation_p.P37L	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	970	MAGE.						protein binding	p.P970H(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGTGGACCCTGATGACTCC	0.478000										HNSCC(15;0.026)			75	60					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53007622	53007622	+	Silent	SNP	G	G	A	rs143904861		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53007622G>A	ENST00000305748.3	-	5	868	c.834C>T	c.(832-834)atC>atT	p.I278I	RP11-641A6.2_ENST00000552364.1_RNA|RP11-641A6.2_ENST00000549180.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	278	Coil 1B.|Rod.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTGGGACTGGATCTGAGCAG	0.567000													31	92					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114379287	114379287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:114379287G>A	ENST00000312719.5	-	5	1363	c.175C>T	c.(175-177)Cgc>Tgc	p.R59C	HS3ST5_ENST00000411826.1_Missense_Mutation_p.R59C|RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000523087.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	59					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TGCAGGGCGCGAAGTGGGAAT	0.577000													12	20					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120389297	120389297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120389297C>T	ENST00000283871.5	-	4	718	c.259G>A	c.(259-261)Gaa>Aaa	p.E87K	HGD_ENST00000488183.1_5'UTR	NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	87					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		GGATCAACTTCATCCCAGTTG	0.423000													33	111					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78917448	78917448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78917448C>T	ENST00000412074.2	-	5	656	c.545G>A	c.(544-546)gGa>gAa	p.G182E	CHRNB4_ENST00000261751.3_3'UTR	NM_001256567.1	NP_001243496.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	0					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CCACTCACATCCTCTCACCCC	0.597000													33	119					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103294589	103294589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103294589C>T	ENST00000424685.2	-	13	1664	c.1505G>A	c.(1504-1506)gGa>gAa	p.G502E	RELN_ENST00000343529.5_Missense_Mutation_p.G502E|RELN_ENST00000428762.1_Missense_Mutation_p.G502E			P78509	RELN_HUMAN	reelin	502					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTCTTTTCTTCCTTCAATTTT	0.398000													28	79					0	0	1	0	0
C20orf85	128602	broad.mit.edu	37	20	56735761	56735761	+	Silent	SNP	C	C	T	rs61749694	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56735761C>T	ENST00000371168.3	+	4	358	c.297C>T	c.(295-297)atC>atT	p.I99I		NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85	99			I -> V (in dbSNP:rs17440813).							kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			AGGGCTTCATCGGCTGGAGAT	0.577000													7	43					0	0	1	0	0
ELF4	2000	broad.mit.edu	37	X	129205174	129205174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:129205174G>A	ENST00000308167.5	-	7	1029	c.650C>T	c.(649-651)gCt>gTt	p.A217V	ELF4_ENST00000335997.7_Missense_Mutation_p.A217V	NM_001421.3	NP_001412.1	Q99607	ELF4_HUMAN	E74-like factor 4 (ets domain transcription factor)	217					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						TTGCAGAAGAGCCAGGAGGAA	0.597000			T	ERG	AML								45	27					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78443370	78443370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78443370C>T	ENST00000278550.7	-	21	3591	c.3129G>A	c.(3127-3129)ccG>ccA	p.P1043P		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CCTGAATTTCCGGCACAATGG	0.517000													16	39					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4835915	4835915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4835915C>T	ENST00000252318.2	+	2	766	c.429C>T	c.(427-429)ctC>ctT	p.L143L	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	143						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CCCAGGACCTCTTCCGGAAGT	0.557000													13	57					0	0	1	0	0
C9orf43	257169	broad.mit.edu	37	9	116175776	116175776	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116175776G>A	ENST00000288462.4	+	2	449	c.3G>A	c.(1-3)atG>atA	p.M1I	C9orf43_ENST00000490544.1_3'UTR|C9orf43_ENST00000374165.1_Start_Codon_SNP_p.M1I	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	1										breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						TTCTAGCTATGGACTTGCCAG	0.498000													17	27					0	0	1	0	0
ABTB2	25841	broad.mit.edu	37	11	34218898	34218898	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:34218898G>A	ENST00000435224.2	-	3	1642	c.1218C>T	c.(1216-1218)ccC>ccT	p.P406P	ABTB2_ENST00000530814.1_5'UTR|ABTB2_ENST00000298992.2_Silent_p.P220P	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	220							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				TCATTCTCGGGGGGTCCAGGT	0.587000													28	30					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018323	1018323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1018323C>T	ENST00000398484.2	+	7	1523	c.943C>T	c.(943-945)Ccc>Tcc	p.P315S	FGFRL1_ENST00000264748.6_Missense_Mutation_p.P315S|FGFRL1_ENST00000510644.1_Missense_Mutation_p.P315S|FGFRL1_ENST00000504138.1_Missense_Mutation_p.P315S			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	315	Ig-like C2-type 3.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GTGGTCGCGGCCCGACGGCTC	0.647000													18	74					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5968191	5968191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:5968191C>T	ENST00000399933.3	-	3	2039	c.2040G>A	c.(2038-2040)atG>atA	p.M680I	KIAA2026_ENST00000381461.2_Missense_Mutation_p.M680I	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	680	Lys-rich.									breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTTTTGCCCTCATTTTAGTTA	0.343000													3	20					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118500911	118500911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:118500911C>T	ENST00000311085.8	+	21	4986	c.4906C>T	c.(4906-4908)Cct>Tct	p.P1636S	DMXL1_ENST00000539542.1_Missense_Mutation_p.P1636S	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1636										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AAAGAATGATCCTTTAGATGC	0.289000													23	73					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242151616	242151616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242151616G>A	ENST00000274979.8	+	16	1934	c.1831G>A	c.(1831-1833)Ggc>Agc	p.G611S	ANO7_ENST00000402430.3_Missense_Mutation_p.G610S	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	611						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						CTTCTTCAAGGGCAGGTTGGT	0.582000													20	60					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209358274	209358274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:209358274G>A	ENST00000272847.2	+	13	1756	c.1543G>A	c.(1543-1545)Gaa>Aaa	p.E515K	PTH2R_ENST00000413482.1_3'UTR|AC019185.4_ENST00000424628.1_RNA	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	515						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GGAGACCAAGGAAGATAGTGG	0.522000													19	50					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53459007	53459007	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:53459007T>A	ENST00000331173.4	-	1	348	c.303A>T	c.(301-303)ttA>ttT	p.L101F	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	101					mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		CAAGGCTCTTTAACTCCTCCT	0.552000													67	143					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995889	140995889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140995889G>A	ENST00000285879.4	+	4	2985	c.2699G>A	c.(2698-2700)aGc>aAc	p.S900N	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	900							protein binding	p.S900I(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTGATAGAGAGCGAGCCCTTG	0.473000										HNSCC(15;0.026)			82	82					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57910260	57910260	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57910260C>T	ENST00000574161.1	+	3	311	c.192C>T	c.(190-192)acC>acT	p.T64T	GCOM1_ENST00000380561.2_Silent_p.T64T|GCOM1_ENST00000572390.1_Silent_p.T64T|GCOM1_ENST00000380560.2_Silent_p.T64T|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Silent_p.T64T|GCOM1_ENST00000587652.1_Silent_p.T64T|GCOM1_ENST00000396180.1_Silent_p.T64T|MYZAP_ENST00000267853.5_Silent_p.T64T|GCOM1_ENST00000380568.3_Silent_p.T64T|MYZAP_ENST00000380565.4_Silent_p.T64T	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		64					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GAGAACCTACCAGGAAACTTC	0.433000													20	83					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739797	38739797	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38739797G>A	ENST00000449082.2	-	27	4913	c.4914C>T	c.(4912-4914)atC>atT	p.I1638I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1638					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACATGTCGTCGATGCCAGCCT	0.552000													48	125					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192701300	192701300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:192701300G>A	ENST00000304141.4	-	2	956	c.627C>T	c.(625-627)ccC>ccT	p.P209P		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	209						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CCTCATCGTGGGGCAAATCAT	0.522000													32	101					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37707063	37707063	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37707063C>T	ENST00000248901.6	+	10	1030	c.843C>T	c.(841-843)ttC>ttT	p.F281F		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	281	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						GGCGCTGGTTCATCCTGACCG	0.627000													58	126					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50679123	50679123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50679123G>A	ENST00000355832.5	-	17	3046	c.2968C>T	c.(2968-2970)Cca>Tca	p.P990S	ERCC6_ENST00000542458.1_Missense_Mutation_p.P360S|RP11-123B3.2_ENST00000423283.1_RNA	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	990	Helicase C-terminal.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CTTTGTTTTGGGTCTTTTAGC	0.348000								Direct reversal of damage;Nucleotide excision repair (NER)					24	119					0	0	1	0	0
P2RY12	64805	broad.mit.edu	37	3	151056190	151056190	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151056190G>A	ENST00000302632.3	-	3	743	c.444C>T	c.(442-444)atC>atT	p.I148I	MED12L_ENST00000491549.1_Intron|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	148					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	TGAATGCCCAGATGACAACAG	0.438000													31	84					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22155537	22155537	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22155537G>A	ENST00000397126.4	-	4	2447	c.2299C>T	c.(2299-2301)Cat>Tat	p.H767Y	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTTTCTTATGATAACTAAGG	0.358000													30	43					0	0	1	0	0
MAGEA11	4110	broad.mit.edu	37	X	148796219	148796219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:148796219G>A	ENST00000355220.5	+	3	277	c.175G>A	c.(175-177)Gat>Aat	p.D59N	MAGEA11_ENST00000333104.4_Missense_Mutation_p.D30N	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	59						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GTGGTCCCAGGATCTGCCAAG	0.532000													16	3					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	160994281	160994281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160994281C>T	ENST00000283249.2	-	10	1561	c.1324G>A	c.(1324-1326)Gat>Aat	p.D442N	ITGB6_ENST00000409872.1_Missense_Mutation_p.D442N|ITGB6_ENST00000428609.2_Missense_Mutation_p.D400N|ITGB6_ENST00000409967.2_Missense_Mutation_p.D442N			P18564	ITB6_HUMAN	integrin, beta 6	442					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						TCCAGGGCATCCCCCAGCCCC	0.493000													7	75					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66204690	66204690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:66204690G>A	ENST00000503581.1	-	4	1151	c.614C>T	c.(613-615)cCa>cTa	p.P205L	EYS_ENST00000393380.2_Missense_Mutation_p.P205L|EYS_ENST00000370616.2_Missense_Mutation_p.P205L|EYS_ENST00000370618.3_Missense_Mutation_p.P205L|EYS_ENST00000370621.3_Missense_Mutation_p.P205L|EYS_ENST00000342421.5_Missense_Mutation_p.P205L	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	205	EGF-like 1.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						TCCAGAAAATGGAGGCTGGCA	0.393000													16	45					0	0	1	0	0
IGSF11	152404	broad.mit.edu	37	3	118621455	118621455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:118621455G>A	ENST00000354673.2	-	9	1585	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	IGSF11_ENST00000491903.1_Missense_Mutation_p.S375F|IGSF11_ENST00000489689.1_Missense_Mutation_p.S379F|IGSF11_ENST00000441144.2_Missense_Mutation_p.S378F|IGSF11_ENST00000425327.2_Missense_Mutation_p.S402F|IGSF11_ENST00000393775.2_Missense_Mutation_p.S403F	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	403					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GATGGTGTAGGAATGAGTGTG	0.547000													37	89					0	0	1	0	0
TMEM35	59353	broad.mit.edu	37	X	100349772	100349772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:100349772C>T	ENST00000372930.4	+	2	614	c.331C>T	c.(331-333)Cct>Tct	p.P111S	TMEM35_ENST00000478351.1_3'UTR	NM_021637.2	NP_067650.1	Q53FP2	TMM35_HUMAN	transmembrane protein 35	111						cytoplasmic membrane-bounded vesicle|integral to membrane|peroxisomal membrane				NS(1)|large_intestine(3)|liver(1)|skin(1)|urinary_tract(1)	7						GGTCGGTGATCCTCTCAAACG	0.567000													45	46					0	0	1	0	0
SEC1P	653677	broad.mit.edu	37	19	49183691	49183691	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49183691G>A	ENST00000430145.2	+	0	778					NR_004401.2																						GCCACATCCCGGGGCGCTGTG	0.657000													18	31					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160147345	160147345	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160147345T>G	ENST00000368081.4	+	18	3098	c.2627T>G	c.(2626-2628)tTt>tGt	p.F876C	ATP1A4_ENST00000470705.1_Missense_Mutation_p.F12C|ATP1A4_ENST00000418334.1_3'UTR	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	876					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTTACCTACTTTGTAATCCTG	0.522000													29	87					0	0	1	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090203	238090203	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:238090203G>A	ENST00000450451.1	+	0	1709					NR_027247.2																						TGCTGGGGACGATGCCCCCCA	0.602000													6	19					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275274	71275274	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71275274C>T	ENST00000399575.2	+	3	403	c.229C>T	c.(229-231)Cga>Tga	p.R77*	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	77	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				TTCTTTCTCTCGATTTAGCCA	0.458000													76	204					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5540495	5540495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5540495G>A	ENST00000382368.3	-	3	1528	c.1405C>T	c.(1405-1407)Ccc>Tcc	p.P469S	FBXL18_ENST00000453700.3_Missense_Mutation_p.P469S	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	469									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GAGGGCTGGGGGCACGCCTGG	0.667000													14	20					0	0	1	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176752	142176752	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142176752G>A	ENST00000390369.2	-	0	38																											CTGTCCCTAGGAAACCCAGGA	0.507000													42	86					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157771	26157771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:26157771G>A	ENST00000325250.1	+	2	856	c.669G>A	c.(667-669)atG>atA	p.M223I		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	223	MAGE.						protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						GGGAAATTATGAATATGATGG	0.473000													6	6					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10073501	10073501	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10073501C>T	ENST00000264828.3	-	65	4930	c.4845G>A	c.(4843-4845)ggG>ggA	p.G1615G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1615	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCACCTTCTTCCCTCGACGGA	0.552000													11	15					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248031355	248031355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248031355G>A	ENST00000366481.3	+	5	909	c.861G>A	c.(859-861)agG>agA	p.R287R	OR2W3_ENST00000537741.1_5'UTR	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	287	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGCTCTTAAGGAAGTTCCAAG	0.507000													3	15					0	0	1	0	0
MAGEA5	4104	broad.mit.edu	37	X	151284190	151284190	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151284190G>A	ENST00000509345.2	-	0	221																											GGCCTCCTGGGGATCCTCTGG	0.532000													11	11					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41066305	41066305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41066305C>T	ENST00000352632.3	+	27	5997	c.5911C>T	c.(5911-5913)Ccc>Tcc	p.P1971S	SPTBN4_ENST00000392025.1_Missense_Mutation_p.P714S|SPTBN4_ENST00000598249.1_Missense_Mutation_p.P1971S|SPTBN4_ENST00000392023.1_Missense_Mutation_p.P647S|SPTBN4_ENST00000595535.1_Missense_Mutation_p.P1971S|SPTBN4_ENST00000338932.3_Missense_Mutation_p.P1971S			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1971					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGCCGACAAGCCCAGGTGCCC	0.657000													36	45					0	0	1	0	0
OR56A4	120793	broad.mit.edu	37	11	6023314	6023314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6023314C>T	ENST00000330728.4	-	1	1110	c.1065G>A	c.(1063-1065)aaG>aaA	p.K355K		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K355N(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGATTCCCTGCTTGATCTCCT	0.433000													31	53					0	0	1	0	0
EAF2	55840	broad.mit.edu	37	3	121591511	121591511	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121591511C>T	ENST00000273668.2	+	5	683	c.612C>T	c.(610-612)tcC>tcT	p.S204S	EAF2_ENST00000451944.2_Silent_p.S204S	NM_018456.4	NP_060926.2	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	204	Necessary for transactivation activity.|Ser-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding	p.S204S(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)	9				GBM - Glioblastoma multiforme(114;0.0972)		ATTGCAAATCCTCTACTTCTG	0.393000													21	125					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7759687	7759687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7759687G>A	ENST00000358415.4	+	6	732	c.566G>A	c.(565-567)aGg>aAg	p.R189K	ITIH2_ENST00000480387.1_3'UTR|ITIH2_ENST00000379587.4_Missense_Mutation_p.R178K	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	189					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						GTGAAGTGGAGGAAGCTGGGC	0.522000													51	144					0	0	1	0	0
NECAB3	63941	broad.mit.edu	37	20	32258570	32258570	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32258570G>A	ENST00000246190.6	-	3	238	c.183C>T	c.(181-183)ttC>ttT	p.F61F	NECAB3_ENST00000375238.4_Silent_p.F61F	NM_031232.3	NP_112509.3	Q96P71	NECA3_HUMAN	N-terminal EF-hand calcium binding protein 3	61	EF-hand.				antibiotic biosynthetic process|protein metabolic process|protein secretion|regulation of amyloid precursor protein biosynthetic process	endoplasmic reticulum membrane|Golgi cis cisterna|nucleus	calcium ion binding|oxidoreductase activity|protein binding			large_intestine(3)|lung(5)|skin(2)	10						AGTAATTCTGGAATTCCTCAA	0.592000													13	40					0	0	1	0	0
TUSC2	11334	broad.mit.edu	37	3	50363574	50363574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50363574G>A	ENST00000232496.4	-	3	454	c.311C>T	c.(310-312)cCt>cTt	p.P104L	TUSC2_ENST00000462137.1_Intron	NM_007275.1	NP_009206.1	O75896	TUSC2_HUMAN	tumor suppressor candidate 2	104					cell cycle|cell proliferation|cell-cell signaling		protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GAGGATCACAGGGAAATCCAC	0.577000													3	12					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520385	33520385	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33520385C>T	ENST00000297307.5	-	1	1027	c.942G>A	c.(940-942)ggG>ggA	p.G314G		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	314	DUF6 2.					integral to membrane											CCAGCACAACCCCTGCCGCCA	0.562000													47	74					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86808051	86808051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86808051G>A	ENST00000441037.2	+	10	1606	c.1511G>A	c.(1510-1512)cGa>cAa	p.R504Q	AGBL1_ENST00000389298.3_Missense_Mutation_p.R235Q|AGBL1_ENST00000421325.2_Missense_Mutation_p.R504Q	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	504					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						ATGTTGGAACGAAAATGTGGA	0.443000													35	56					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73464833	73464833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73464833G>A	ENST00000224721.6	+	24	2919	c.2914G>A	c.(2914-2916)Gcc>Acc	p.A972T	CDH23_ENST00000299366.7_Missense_Mutation_p.A1012T	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	967	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCGGGTGGTGGCCAGTGATGC	0.667000													27	41					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124591827	124591827	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124591827T>C	ENST00000368904.1	-	11	2740	c.1791A>G	c.(1789-1791)gcA>gcG	p.A597A	CUZD1_ENST00000392790.1_Silent_p.A597A|CUZD1_ENST00000545804.1_Silent_p.A597A			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	597					cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		ATTTGTAGTCTGCCCGTTGAT	0.448000													21	215					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6937593	6937593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6937593G>A	ENST00000312053.4	+	20	2626	c.2589G>A	c.(2587-2589)acG>acA	p.T863T	EMR1_ENST00000381407.5_Silent_p.T722T|EMR1_ENST00000381404.4_Silent_p.T844T|EMR1_ENST00000250572.8_Silent_p.T798T|EMR1_ENST00000450315.3_Silent_p.T686T	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	863					cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CTGGGAAGACGAAGCCCAGCT	0.557000													29	131					0	0	1	0	0
GRIN3B	116444	broad.mit.edu	37	19	1005273	1005273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1005273C>T	ENST00000234389.3	+	3	1792	c.1773C>T	c.(1771-1773)ttC>ttT	p.F591F	GRIN3B_ENST00000588335.1_3'UTR	NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	591					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity			breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCGCGCTCTTCCTCACCGTGT	0.667000													22	72					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299207	58299207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58299207G>A	ENST00000377918.3	+	4	3285	c.3259G>A	c.(3259-3261)Gac>Aac	p.D1087N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1087					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCAACCAAGAGACCCTCCCTT	0.532000													38	102					0	0	1	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32713809	32713809	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32713809G>A	ENST00000374940.3	+	3	675	c.573G>A	c.(571-573)gtG>gtA	p.V191V		NM_020056.4	NP_064440.1	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ alpha 2	191	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			endometrium(2)|large_intestine(3)|lung(7)|skin(1)	13					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACTGCAAGGTGGAGCACTGGG	0.473000													15	216					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5672668	5672668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5672668C>T	ENST00000546188.1	-	26	2868	c.2797G>A	c.(2797-2799)Gac>Aac	p.D933N	ANO2_ENST00000356134.5_Missense_Mutation_p.D933N|ANO2_ENST00000327087.8_Missense_Mutation_p.D932N			Q9NQ90	ANO2_HUMAN	anoctamin 2	937						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TTGATCTGGTCGCTGATGTCC	0.527000													11	63					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129148439	129148439	+	Missense_Mutation	SNP	C	C	T	rs144104600		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:129148439C>T	ENST00000540052.1	+	3	1735	c.1691C>T	c.(1690-1692)cCa>cTa	p.P564L	BCORL1_ENST00000218147.7_Missense_Mutation_p.P564L|BCORL1_ENST00000359304.2_Missense_Mutation_p.P564L|BCORL1_ENST00000303743.5_Missense_Mutation_p.P564L	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	564	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CTTCCAACTCCACAGCCTCTG	0.637000													31	60					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203691724	203691724	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203691724C>G	ENST00000357681.5	+	18	4054	c.2931C>G	c.(2929-2931)aaC>aaG	p.N977K	ATP2B4_ENST00000391954.2_Missense_Mutation_p.N977K|ATP2B4_ENST00000367219.3_Missense_Mutation_p.N965K|ATP2B4_ENST00000341360.2_Missense_Mutation_p.N977K|ATP2B4_ENST00000367218.3_Missense_Mutation_p.N977K	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	977					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATGAAATCAACTCCCGAAAGA	0.463000													22	90					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210970944	210970944	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210970944G>A	ENST00000367007.4	-	9	1909	c.1740C>T	c.(1738-1740)ctC>ctT	p.L580L	KCNH1_ENST00000271751.4_Silent_p.L607L	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	607					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CATGGTAGATGAGGTCCCCTG	0.602000													43	77					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96163655	96163655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:96163655G>A	ENST00000453304.1	-	7	1381	c.1033C>T	c.(1033-1035)Ccc>Tcc	p.P345S	UNC5C_ENST00000506749.1_Missense_Mutation_p.P345S	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	345	TSP type-1 2.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CCATTCTTGGGGGCTGGCGCC	0.567000													12	25					0	0	1	0	0
MAP1S	55201	broad.mit.edu	37	19	17838113	17838113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17838113C>T	ENST00000324096.4	+	5	2071	c.1920C>T	c.(1918-1920)tcC>tcT	p.S640S	MAP1S_ENST00000597681.1_3'UTR|MAP1S_ENST00000544059.2_Silent_p.S614S	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	640	Necessary for the microtubule-organizing center localization.|Pro-rich.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						GCACACCCTCCCCTGAGTCCC	0.726000													5	8					0	0	1	0	0
BCL2L15	440603	broad.mit.edu	37	1	114424416	114424416	+	Silent	SNP	G	G	A	rs114942995	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114424416G>A	ENST00000393316.3	-	3	624	c.453C>T	c.(451-453)ttC>ttT	p.F151F	BCL2L15_ENST00000488450.1_5'UTR|BCL2L15_ENST00000471267.1_Intron|AP4B1-AS1_ENST00000419536.1_RNA|BCL2L15_ENST00000393320.3_Intron	NM_001010922.2	NP_001010922.1	Q5TBC7	B2L15_HUMAN	BCL2-like 15	151					apoptosis					breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(3)|ovary(1)	9	Lung SC(450;0.184)	all_cancers(81;3.95e-08)|all_epithelial(167;9.95e-08)|all_lung(203;1.31e-05)|Lung NSC(69;2.46e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCCCTGGATGAACTCCCGGA	0.493000													6	25					0	0	1	0	0
PATL1	219988	broad.mit.edu	37	11	59406585	59406585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59406585G>A	ENST00000300146.9	-	18	2311	c.2227C>T	c.(2227-2229)Cta>Tta	p.L743L	AP000442.1_ENST00000531108.1_RNA|AP000442.1_ENST00000531311.1_RNA	NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	743	Region C.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						AGGGACACTAGGTTTGTAGGT	0.488000													13	48					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099642	168099642	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168099642C>T	ENST00000409195.1	+	9	1829	c.1740C>T	c.(1738-1740)atC>atT	p.I580I	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Silent_p.I580I|XIRP2_ENST00000409273.1_Silent_p.I358I|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	405					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTAGATGGATCTTTGAGAATC	0.408000													20	65					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55582700	55582700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55582700C>T	ENST00000361849.3	-	34	5186	c.4792G>A	c.(4792-4794)Gat>Aat	p.D1598N	PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.D1527N|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.D1573N|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.D1556N|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.D1593N|PCDH15_ENST00000320301.6_Missense_Mutation_p.D1596N|PCDH15_ENST00000395438.1_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1596					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.D1596Y(1)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCTGCAGATCTATGATCTCT	0.468000										HNSCC(58;0.16)			16	173					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717183	222717183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:222717183G>A	ENST00000343410.6	-	2	728	c.670C>T	c.(670-672)Cat>Tat	p.H224Y		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	224					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		TCCCCAGCATGGACCATGGAG	0.642000													26	39					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433101	140433101	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140433101A>G	ENST00000306549.3	+	1	2123	c.2046A>G	c.(2044-2046)agA>agG	p.R682R		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		682					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCATTCTAGAAAGGTAAATC	0.438000													59	195					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6678261	6678261	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6678261G>A	ENST00000245907.6	-	40	4844	c.4752C>T	c.(4750-4752)ttC>ttT	p.F1584F	C3_ENST00000599668.1_5'UTR	NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1584	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGGGGCTGATGAACGTGCGCT	0.592000													21	34					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791924	95791924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95791924C>T	ENST00000260766.3	+	2	1755	c.1121C>T	c.(1120-1122)cCt>cTt	p.P374L	PLCE1_ENST00000371380.2_Missense_Mutation_p.P374L	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	374					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				CCCTTACTGCCTTGTGGGAGA	0.483000													20	66					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93964487	93964487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:93964487C>T	ENST00000369303.4	-	14	2594	c.2410G>A	c.(2410-2412)Gca>Aca	p.A804T		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	804	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GCTTCGGGTGCTGTCCACCTT	0.353000													13	23					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480413	140480413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140480413C>T	ENST00000231130.2	+	1	180	c.180C>T	c.(178-180)gcC>gcT	p.A60A	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		60	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGAACTGGCCGCGAGGGGGG	0.507000													35	79					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743739	81743739	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81743739C>T	ENST00000555447.1	-	6	2328	c.1916G>A	c.(1915-1917)tGg>tAg	p.W639*	STON2_ENST00000267540.2_Nonsense_Mutation_p.W639*	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	639	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GAGCTTGATCCACTTTGTGGT	0.527000													16	45					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109103343	109103343	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:109103343C>T	ENST00000261483.4	+	6	1995	c.943C>T	c.(943-945)Cat>Tat	p.H315Y		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	315					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		CCAGAGAGTTCATTATGCAGT	0.423000													62	139					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757986	8757986	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8757986C>T	ENST00000229335.6	-	3	355	c.252G>A	c.(250-252)tgG>tgA	p.W84*	AICDA_ENST00000537228.1_Nonsense_Mutation_p.W84*	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	84					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					AGCAGGGGCTCCAGGAGGTGA	0.617000													22	51					0	0	1	0	0
DYDC1	143241	broad.mit.edu	37	10	82098192	82098192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:82098192G>A	ENST00000421924.2	-	6	946	c.535C>T	c.(535-537)Cgt>Tgt	p.R179C	DYDC1_ENST00000372204.3_Intron|DYDC1_ENST00000372202.1_Intron			Q8WWB3	DYDC1_HUMAN	DPY30 domain containing 1	0										kidney(1)|large_intestine(3)|skin(1)	5			Colorectal(32;0.229)			aaacaaaaacGAGTTTTTTCA	0.383000													15	47					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112029769	112029769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112029769G>A	ENST00000374566.3	-	4	1034	c.517C>T	c.(517-519)Cgt>Tgt	p.R173C	EPB41L4B_ENST00000374557.4_Missense_Mutation_p.R173C	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	173	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AACTCCTCACGAAGGTTGTTT	0.443000													37	64					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54856251	54856251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:54856251C>T	ENST00000333896.5	+	13	2326	c.1941C>T	c.(1939-1941)atC>atT	p.I647I	SPTBN1_ENST00000356805.4_Silent_p.I660I	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	660					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			AGGAGAAGATCCTGTCCTCGG	0.627000													37	87					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622675	38622675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38622675G>A	ENST00000413689.1	-	17	3168	c.2975C>T	c.(2974-2976)cCc>cTc	p.P992L	SCN5A_ENST00000423572.2_Missense_Mutation_p.P992L|SCN5A_ENST00000425664.1_Missense_Mutation_p.P992L|SCN5A_ENST00000333535.4_Missense_Mutation_p.P992L|SCN5A_ENST00000451551.2_Missense_Mutation_p.P992L|SCN5A_ENST00000455624.2_Missense_Mutation_p.P992L|SCN5A_ENST00000449557.2_Missense_Mutation_p.P992L|SCN5A_ENST00000450102.2_Missense_Mutation_p.P992L|SCN5A_ENST00000443581.1_Missense_Mutation_p.P992L|SCN5A_ENST00000414099.2_Missense_Mutation_p.P992L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	992					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AAGGGCTGCGGGCTTCTGAGG	0.692000													6	14					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167141089	167141089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167141089C>T	ENST00000375387.4	-	12	2191	c.1851G>A	c.(1849-1851)ggG>ggA	p.G617G	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Silent_p.G616G|SCN9A_ENST00000409672.1_Silent_p.G616G|SCN9A_ENST00000303354.6_Silent_p.G617G			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	616						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGTGCATTTTCCCGTTCACCG	0.587000													20	51					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201460056	201460056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:201460056G>A	ENST00000374700.2	+	3	406	c.165G>A	c.(163-165)atG>atA	p.M55I		NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	55	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTACAGTGATGATATCACGAT	0.398000													14	31					0	0	1	0	0
AKR1B15	441282	broad.mit.edu	37	7	134256361	134256361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:134256361G>A	ENST00000457545.2	+	6	701	c.441G>A	c.(439-441)ggG>ggA	p.G147G	AKR1B15_ENST00000423958.1_Silent_p.G119G	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	147							oxidoreductase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						TACAGACTGGGGATGACTTTT	0.418000													10	106					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34174801	34174801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34174801G>A	ENST00000373381.4	-	22	3640	c.3464C>T	c.(3463-3465)cCt>cTt	p.P1155L	CSMD2_ENST00000373380.1_Missense_Mutation_p.P28L|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1115	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTAGTTCACAGGAAAGTTGGG	0.483000													19	56					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993665	140993665	+	Missense_Mutation	SNP	C	C	T	rs74966399		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140993665C>T	ENST00000285879.4	+	4	761	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	159							protein binding	p.P159S(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGGGTTTTCCCCAGTCTGT	0.488000										HNSCC(15;0.026)			87	65					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103091352	103091352	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103091352C>T	ENST00000375735.2	+	57	9091	c.8946_splice	c.e57-1	p.P2983_splice	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Splice_Site_p.P2983_splice	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2983	Stalk (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCTCTTTTAGCCTTTAGTCAA	0.303000													38	91					0	0	1	0	0
ASPG	374569	broad.mit.edu	37	14	104571689	104571689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104571689G>A	ENST00000551177.1	+	10	1167	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K	ASPG_ENST00000549809.1_3'UTR|ASPG_ENST00000546892.2_Missense_Mutation_p.E359K|ASPG_ENST00000455920.2_Missense_Mutation_p.E359K	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	359					lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						CCTTCGGGGGGAGATGACGCC	0.677000													5	32					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580505	140580505	+	Silent	SNP	G	G	A	rs57445845	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580505G>A	ENST00000354757.3	+	1	1158	c.1158G>A	c.(1156-1158)ccG>ccA	p.P386P	PCDHB11_ENST00000536699.1_Silent_p.P21P	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		386	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCCATTCCGGAAGACCTCC	0.448000													32	114					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96909112	96909112	+	Missense_Mutation	SNP	G	G	A	rs112200493		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96909112G>A	ENST00000267584.4	+	7	780	c.736G>A	c.(736-738)Gga>Aga	p.G246R		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	246					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TTTTGGCGATGGAACAAATGT	0.423000													60	137					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152861154	152861154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152861154C>T	ENST00000367255.5	-	4	671	c.70G>A	c.(70-72)Gag>Aag	p.E24K	SYNE1_ENST00000466159.2_Missense_Mutation_p.E24K|SYNE1_ENST00000413186.2_Missense_Mutation_p.E24K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E24K|SYNE1_ENST00000367253.4_Missense_Mutation_p.E24K|SYNE1_ENST00000367248.3_Missense_Mutation_p.E24K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E24K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E24K|SYNE1_ENST00000341594.5_Missense_Mutation_p.E24K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	24	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATCTCTTGCTCATCTAGAAGG	0.343000										HNSCC(10;0.0054)			25	48					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447223	226447223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:226447223C>T	ENST00000272907.6	+	4	1503	c.1090C>T	c.(1090-1092)Ccc>Tcc	p.P364S	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	364	Pro-rich.																CACGAAGCTTCCCGTGCTGGA	0.637000													18	31					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26115908	26115908	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26115908G>A	ENST00000313735.6	-	4	478	c.245C>T	c.(244-246)cCa>cTa	p.P82L		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	82					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CACATGCCGTGGGGAGGACAA	0.532000													61	69					0	0	1	0	0
RPL13AP3	645683	broad.mit.edu	37	14	56233097	56233097	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:56233097G>A	ENST00000554458.1	+	0	75				RPL13AP3_ENST00000494676.1_RNA																							AACCCTTTTCGAAGCGCCTAC	0.572000													7	18					0	0	1	0	0
C15orf54	400360	broad.mit.edu	37	15	39544521	39544521	+	Missense_Mutation	SNP	C	C	T	rs140379180	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39544521C>T	ENST00000318578.3	+	2	553	c.185C>T	c.(184-186)cCt>cTt	p.P62L	RP11-624L4.1_ENST00000560484.1_RNA|RP11-624L4.1_ENST00000561058.1_RNA|RP11-624L4.1_ENST00000558209.1_RNA|C15orf54_ENST00000561223.1_Missense_Mutation_p.P62L	NM_207445.2	NP_997328.1	Q8N8G6	CO054_HUMAN	chromosome 15 open reading frame 54	62										NS(1)|haematopoietic_and_lymphoid_tissue(2)|lung(2)	5		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		ACGGAGCTCCCTCTCAGGTTC	0.443000													109	289					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1994036	1994036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1994036G>A	ENST00000382722.5	-	11	1532	c.1170C>T	c.(1168-1170)gcC>gcT	p.A390A	CACNA2D4_ENST00000585708.1_Silent_p.A326A|CACNA2D4_ENST00000587995.1_Silent_p.A390A|CACNA2D4_ENST00000586184.1_Silent_p.A390A|CACNA2D4_ENST00000585732.1_Silent_p.A306A|CACNA2D4_ENST00000588077.1_Silent_p.A326A	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	390	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TTCCTTGCTTGGCCTCTTGGA	0.617000													10	29					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169566	113169566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113169566C>T	ENST00000401783.2	-	38	8650	c.8314G>A	c.(8314-8316)Gcc>Acc	p.A2772T	SVEP1_ENST00000374469.1_Missense_Mutation_p.A2749T|SVEP1_ENST00000297826.5_Missense_Mutation_p.A698T	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2772	Sushi 22.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CATGAAATGGCTTCACAGCGT	0.463000													38	86					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24581994	24581994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24581994C>T	ENST00000358321.3	+	9	1611	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	450	VWFD.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						CCTCCGCCTTCGGAGACCCAC	0.652000													12	24					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142021110	142021110	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142021110G>A	ENST00000390381.3	+	0	399																											CAAGATATCTGATCAAAACGA	0.547000													12	40					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10251308	10251308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10251308C>T	ENST00000256458.4	+	4	550	c.460C>T	c.(460-462)Ctc>Ttc	p.L154F		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	154					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						GCCGGCCTTTCTCCAGCCTCC	0.602000													116	232					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43243836	43243836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43243836C>T	ENST00000255226.6	+	11	2254	c.1438C>T	c.(1438-1440)Cac>Tac	p.H480Y	SLC14A2_ENST00000586448.1_Missense_Mutation_p.H480Y	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	480						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GAGTGTATTTCACATCGAGTG	0.582000													11	26					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47925324	47925324	+	Silent	SNP	C	C	T	rs141356808		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47925324C>T	ENST00000289672.2	-	18	3215	c.3165G>A	c.(3163-3165)gaG>gaA	p.E1055E		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1055	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GCTGACTTCTCTCAGAGCGGC	0.587000													32	89					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579609	140579609	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140579609G>A	ENST00000354757.3	+	1	262	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		88	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCTTAAGTGAAACACTAGA	0.493000													49	96					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27720202	27720202	+	Missense_Mutation	SNP	G	G	A	rs148289865		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27720202G>A	ENST00000264717.2	+	2	215	c.152G>A	c.(151-153)cGa>cAa	p.R51Q	GCKR_ENST00000424318.2_5'UTR	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	51					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					AACATTGTTCGACTGCTAGGG	0.517000													30	50					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168103420	168103420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168103420G>A	ENST00000409195.1	+	9	5607	c.5518G>A	c.(5518-5520)Gat>Aat	p.D1840N	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D1840N|XIRP2_ENST00000409273.1_Missense_Mutation_p.D1618N|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1665					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TATAAAAGGTGATTTGACATC	0.388000													37	107					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112770152	112770152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:112770152C>T	ENST00000390666.3	-	1	576	c.385G>A	c.(385-387)Gac>Aac	p.D129N	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000416046.2_RNA|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	129	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		ACGTCCAGGTCGTGGCAGTAC	0.562000													10	55					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126134603	126134603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126134603G>A	ENST00000373631.3	+	9	2585	c.2584G>A	c.(2584-2586)Gtc>Atc	p.V862I	CRB2_ENST00000373629.2_Missense_Mutation_p.V530I|CRB2_ENST00000359999.3_Missense_Mutation_p.V862I	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	862						extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						GTGTGAGGAGGTCCCTGATGG	0.617000													15	64					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4841445	4841445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4841445G>A	ENST00000399583.3	-	12	2868	c.2681C>T	c.(2680-2682)cCc>cTc	p.P894L	RADIL_ENST00000536091.1_3'UTR|RADIL_ENST00000538469.1_Missense_Mutation_p.P654L	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	894	Pro-rich.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGTGTGCGGGGGGCCAGCCTG	0.726000													12	14					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18331249	18331249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18331249C>T	ENST00000355502.3	-	10	1543	c.672G>A	c.(670-672)caG>caA	p.Q224Q	PDE4C_ENST00000594465.2_Silent_p.Q224Q|PDE4C_ENST00000262805.11_Silent_p.Q192Q|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000539010.1_5'UTR|PDE4C_ENST00000447275.2_Silent_p.Q118Q|PDE4C_ENST00000594617.2_Silent_p.Q224Q			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	224					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	AGTGCCGGGTCTGCAGCGTCT	0.652000													16	41					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32630909	32630909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32630909G>A	ENST00000242310.4	-	1	4758	c.4669C>T	c.(4669-4671)Cca>Tca	p.P1557S		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1557	Bromo 2.				male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TAATAATCTGGAACAAACTTC	0.388000													32	69					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164732947	164732947	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164732947G>A	ENST00000264382.3	-	33	4025	c.3963C>T	c.(3961-3963)gtC>gtT	p.V1321V		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1321	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTGGCCATTTGACAAAGACAT	0.303000										HNSCC(35;0.089)			18	61					0	0	1	0	0
MIXL1	83881	broad.mit.edu	37	1	226413318	226413318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226413318G>A	ENST00000366810.5	+	2	568	c.504G>A	c.(502-504)acG>acA	p.T168T	MIXL1_ENST00000542034.1_Silent_p.T176T|MIXL1_ENST00000557734.1_3'UTR			Q9H2W2	MIXL1_HUMAN	Mix paired-like homeobox	168					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.109)		GAACTGAAACGAAATGTCTGA	0.557000													37	70					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25423794	25423794	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25423794C>T	ENST00000441592.2	+	0	365																											AGCTCAAGCCCTTCCTGGTGC	0.617000													39	33					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32595859	32595859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32595859G>A	ENST00000286827.3	-	9	2329	c.1858C>T	c.(1858-1860)Cgt>Tgt	p.R620C	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Missense_Mutation_p.R620C	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	620					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CAGCGGAAACGAAACAGGTCC	0.478000													27	76					0	0	1	0	0
FIGN	55137	broad.mit.edu	37	2	164467888	164467888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:164467888G>A	ENST00000333129.3	-	3	768	c.454C>T	c.(454-456)Cct>Tct	p.P152S	FIGN_ENST00000409634.1_Intron|FIGN_ENST00000482917.1_5'UTR	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	152						nuclear matrix	ATP binding|nucleoside-triphosphatase activity	p.P152A(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						GCTACCCCAGGAGAGCTTCCT	0.512000													14	104					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18871008	18871008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:18871008G>A	ENST00000446231.2	-	27	4235	c.3823C>T	c.(3823-3825)Cct>Tct	p.P1275S	SMG1_ENST00000389467.3_Missense_Mutation_p.P1275S			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	1275	FAT.|Interaction with SMG8 and SMG9.		P -> R.		DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AACATGTTAGGAAGCAGTTTT	0.313000													21	40					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128483850	128483850	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128483850G>A	ENST00000325888.8	+	19	3073	c.2811_splice	c.e19-1	p.G938_splice	FLNC_ENST00000346177.6_Splice_Site_p.G938_splice	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	938					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TACCCAACAGGGCAACATGGC	0.527000													76	100					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61652454	61652454	+	Missense_Mutation	SNP	C	C	T	rs141770995		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61652454C>T	ENST00000397985.2	+	6	951	c.695C>T	c.(694-696)cCc>cTc	p.P232L	SERPINB8_ENST00000397988.3_Missense_Mutation_p.P232L|SERPINB8_ENST00000353706.2_Missense_Mutation_p.P232L|SERPINB8_ENST00000493661.1_3'UTR|SERPINB8_ENST00000542677.1_Missense_Mutation_p.P50L	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	232					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				ATTCTGCTTCCCGATGACAAC	0.507000													14	51					0	0	1	0	0
N4BP1	9683	broad.mit.edu	37	16	48580147	48580147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48580147G>A	ENST00000262384.3	-	6	2480	c.2244C>T	c.(2242-2244)ttC>ttT	p.F748F	N4BP1_ENST00000565423.1_Intron	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	748					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				TGTCCCCCACGAACGTGTACT	0.517000													6	87					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103566713	103566713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103566713C>T	ENST00000380069.3	+	1	233	c.157C>T	c.(157-159)Ctg>Ttg	p.L53L		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	53										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CCTGGGCTCCCTGAGGCAGGC	0.657000													7	12					0	0	1	0	0
GBP6	163351	broad.mit.edu	37	1	89844102	89844102	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89844102G>A	ENST00000370456.4	+	5	648	c.555G>A	c.(553-555)ctG>ctA	p.L185L	GBP6_ENST00000535065.1_Silent_p.L55L	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	185							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ATTTCACTCTGGAGCTGAAGT	0.483000													31	102					0	0	1	0	0
B3GALT4	8705	broad.mit.edu	37	6	33246057	33246057	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33246057C>T	ENST00000451237.1	+	1	1141	c.861C>T	c.(859-861)ctC>ctT	p.L287L		NM_003782.3	NP_003773.1	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	287					protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	13						CACCCCTTCTCCCATTAGAGG	0.627000													25	57					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56934979	56934979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56934979C>T	ENST00000333201.9	+	5	1162	c.952C>T	c.(952-954)Cat>Tat	p.H318Y	ZNF583_ENST00000585612.1_3'UTR|ZNF583_ENST00000291598.7_Missense_Mutation_p.H318Y	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		TCAGAGAGTTCATACTGGAGA	0.413000													18	133					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24447200	24447200	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24447200C>T	ENST00000230036.1	-	18	1796	c.1686G>A	c.(1684-1686)ctG>ctA	p.L562L		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	562						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						CCTCCACGTTCAGTTTTTCTA	0.453000													24	72					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149263071	149263071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149263071C>T	ENST00000255266.5	-	17	2175	c.2056G>A	c.(2056-2058)Gat>Aat	p.D686N		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	686					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TTAGACTGATCCACGATCTTT	0.443000													5	55					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8637897	8637897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:8637897C>T	ENST00000378641.3	+	8	1136	c.661C>T	c.(661-663)Cct>Tct	p.P221S	PLCB1_ENST00000338037.6_Missense_Mutation_p.P221S|PLCB1_ENST00000378637.2_Missense_Mutation_p.P221S	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	221				P -> L (in Ref. 2; AAF86613).	activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CAACCTTTGCCCTCGACCTGA	0.393000													15	131					0	0	1	0	0
NHLH2	4808	broad.mit.edu	37	1	116380921	116380921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:116380921C>T	ENST00000369506.1	-	1	5617	c.73G>A	c.(73-75)Ggc>Agc	p.G25S	NHLH2_ENST00000320238.3_Missense_Mutation_p.G25S			Q02577	HEN2_HUMAN	nescient helix loop helix 2	25					cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			prostate(1)	1	Lung SC(450;0.184)	all_cancers(81;1.75e-06)|all_epithelial(167;1.16e-06)|all_lung(203;9.55e-06)|Lung NSC(69;5.83e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TCCGTGCCGCCCAGGGACTCC	0.677000													7	20					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18745386	18745386	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18745386C>T	ENST00000304081.4	-	9	1430		c.e9-1		NT5C1B_ENST00000359846.2_Splice_Site|NT5C1B-RDH14_ENST00000532967.1_Splice_Site|NT5C1B_ENST00000600945.1_Splice_Site	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TTAGGGGACCCTGTAAAAGGA	0.388000													26	81					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217279704	217279704	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:217279704C>T	ENST00000357276.4	+	3	607	c.277C>T	c.(277-279)Cag>Tag	p.Q93*	SMARCAL1_ENST00000358207.5_Nonsense_Mutation_p.Q93*	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	93					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCACAGTTTTCAGGCAAAGGG	0.483000									Schimke Immuno-Osseous Dysplasia				20	46					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26695000	26695000	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26695000C>T	ENST00000396005.3	-	14	1965	c.1656G>A	c.(1654-1656)aaG>aaA	p.K552K		NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	552					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GTGTTTTGTACTTCTTAGACC	0.383000													59	140					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1189698	1189698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:1189698G>A	ENST00000446702.2	+	2	633	c.6G>A	c.(4-6)agG>agA	p.R2R	CNTN6_ENST00000539053.1_Intron|CNTN6_ENST00000350110.2_Silent_p.R2R			Q9UQ52	CNTN6_HUMAN	contactin 6	2					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TGGAAATGAGGTTGCTATGGA	0.348000													16	134					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75111623	75111623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75111623C>T	ENST00000379709.3	+	6	730	c.728C>T	c.(727-729)cCc>cTc	p.P243L	LMAN1L_ENST00000309664.5_Intron			Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	255	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGTGAGGATCCCACTGGACAG	0.572000													43	165					0	0	1	0	0
SLAIN1	122060	broad.mit.edu	37	13	78335025	78335025	+	Nonsense_Mutation	SNP	C	C	T	rs142633526		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:78335025C>T	ENST00000466548.1	+	7	1437	c.1411C>T	c.(1411-1413)Cga>Tga	p.R471*	SLAIN1_ENST00000358679.3_Nonsense_Mutation_p.R208*|SLAIN1_ENST00000351546.3_Nonsense_Mutation_p.R208*|SLAIN1_ENST00000314070.5_Nonsense_Mutation_p.R94*|SLAIN1_ENST00000418532.1_Nonsense_Mutation_p.R252*|SLAIN1_ENST00000267219.8_Nonsense_Mutation_p.R252*|SLAIN1_ENST00000488699.1_Nonsense_Mutation_p.R329*	NM_001242868.1	NP_001229797.1	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1	471								p.R252*(1)		breast(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		AGTGTCTATCCGACAGCCTCT	0.478000													37	109					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992447	85992447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85992447C>T	ENST00000372105.3	-	4	1129	c.1108G>A	c.(1108-1110)Gaa>Aaa	p.E370K		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	370						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GCAGCAGCTTCCCCTCCGCCA	0.577000													6	16					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760570	19760570	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19760570G>A	ENST00000357324.6	-	18	2541	c.2515C>T	c.(2515-2517)Cgt>Tgt	p.R839C	ATP13A1_ENST00000291503.5_Missense_Mutation_p.R721C	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	839					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGAGCCACACGGGCGAACACC	0.672000													19	56					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10243554	10243554	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10243554C>T	ENST00000418404.3	-	17	2132	c.1968_splice	c.e17-1	p.E657_splice	MYH13_ENST00000570743.1_Splice_Site_p.E657_splice|MYH13_ENST00000252172.4_Splice_Site_p.E657_splice|RP11-401O9.3_ENST00000577743.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	657	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TTTAAATTTTCCTGGGACATA	0.433000													16	18					0	0	1	0	0
SCP2D1	140856	broad.mit.edu	37	20	18794508	18794508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:18794508C>T	ENST00000377428.2	+	1	139	c.49C>T	c.(49-51)Cct>Tct	p.P17S	C20orf78_ENST00000278779.4_Intron	NM_178483.2	NP_848578.1			SCP2 sterol-binding domain containing 1																		AGAGGATGGACCTCTGGTGGG	0.522000													11	49					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155157067	155157067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155157067C>T	ENST00000357232.3	-	25	7371	c.7372G>A	c.(7372-7374)Gga>Aga	p.G2458R		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2458	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGAATGACTCCATCAATACCA	0.378000													43	108					0	0	1	0	0
PARM1	25849	broad.mit.edu	37	4	75937790	75937790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:75937790C>T	ENST00000307428.7	+	2	411	c.199C>T	c.(199-201)Cca>Tca	p.P67S	RP11-44F21.2_ENST00000513770.1_RNA|PARM1_ENST00000513238.1_Intron	NM_015393.3	NP_056208.2	Q6UWI2	PARM1_HUMAN	prostate androgen-regulated mucin-like protein 1	67					positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						CTCGGTGCTCCCAGTTACAGC	0.517000													19	72					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176520672	176520672	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176520672C>G	ENST00000292408.4	+	11	1660	c.1415C>G	c.(1414-1416)cCc>cGc	p.P472R	FGFR4_ENST00000502906.1_Missense_Mutation_p.P472R|FGFR4_ENST00000393648.2_Missense_Mutation_p.P404R|FGFR4_ENST00000393637.1_Missense_Mutation_p.P432R|FGFR4_ENST00000292410.3_Missense_Mutation_p.P432R	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	472	Protein kinase.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CTTGGGAAGCCCCTAGGCGAG	0.667000										TSP Lung(9;0.080)			14	56					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	131781525	131781525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:131781525G>A	ENST00000374786.1	+	1	629	c.150G>A	c.(148-150)ggG>ggA	p.G50G	NTM_ENST00000539799.1_Silent_p.G50G|NTM_ENST00000374784.1_Silent_p.G50G|NTM_ENST00000374791.3_Silent_p.G50G|NTM_ENST00000425719.2_Silent_p.G50G|NTM_ENST00000427481.2_Silent_p.G41G	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	50	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						TCCGGCAGGGGGAGAGCGCCA	0.612000											OREG0021537	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	89					0	0	1	0	0
USP19	10869	broad.mit.edu	37	3	49146461	49146461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49146461G>A	ENST00000434032.2	-	27	4401	c.4190C>T	c.(4189-4191)aCc>aTc	p.T1397I	USP19_ENST00000398896.1_Intron|USP19_ENST00000398888.2_Missense_Mutation_p.T1296I|USP19_ENST00000398898.2_Intron|USP19_ENST00000398892.3_Missense_Mutation_p.T1336I|USP19_ENST00000453664.1_Intron|USP19_ENST00000417901.1_Intron	NM_001199160.1	NP_001186089.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	1296					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGCCGCCACGGTGCCCAGGAC	0.662000													4	17					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75072303	75072303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75072303C>T	ENST00000326665.5	-	10	1689	c.1471G>A	c.(1471-1473)Gaa>Aaa	p.E491K	C1orf173_ENST00000420661.2_Missense_Mutation_p.E294K|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	491	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AAAGTATTTTCCTGGTCGTCT	0.358000													12	181					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6623959	6623959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6623959C>T	ENST00000315579.5	+	9	1659	c.860C>T	c.(859-861)cCc>cTc	p.P287L	NCAPD2_ENST00000545962.1_Missense_Mutation_p.P242L	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	287	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						CAAAAGTGTCCCCAAGAGCTG	0.478000													23	71					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35616947	35616947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:35616947C>T	ENST00000287272.2	+	13	2086	c.2066C>T	c.(2065-2067)cCc>cTc	p.P689L	UNC5D_ENST00000416672.1_Missense_Mutation_p.P763L|UNC5D_ENST00000420357.1_Missense_Mutation_p.P691L|UNC5D_ENST00000404895.2_Missense_Mutation_p.P758L|UNC5D_ENST00000453357.2_Missense_Mutation_p.P753L|UNC5D_ENST00000449677.1_Missense_Mutation_p.P334L			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	758					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTTGATATTCCCCCATTCCTC	0.448000													39	155					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53269757	53269757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53269757C>T	ENST00000338230.3	-	3	1519	c.1252G>A	c.(1252-1254)Gaa>Aaa	p.E418K		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		TTCCCACATTCATTACACTTG	0.358000													27	121					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178418886	178418886	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178418886G>A	ENST00000231188.5	-	2	881	c.703C>T	c.(703-705)Cag>Tag	p.Q235*	GRM6_ENST00000517717.1_Nonsense_Mutation_p.Q235*	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	235					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CGGGAGATCTGAACGAAGGCC	0.617000													11	26					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	66980196	66980196	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66980196C>T	ENST00000340001.4	-	35	4711		c.e35+1		ABCA9_ENST00000370732.2_Splice_Site|ABCA9_ENST00000453985.2_Splice_Site	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9						transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					CAGGCACTCACCTCAGCCTTC	0.592000													45	80					0	0	1	0	0
PPP1CA	5499	broad.mit.edu	37	11	67166500	67166500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67166500C>T	ENST00000376745.4	-	5	806	c.658G>A	c.(658-660)Gac>Aac	p.D220N	PPP1CA_ENST00000312989.7_Missense_Mutation_p.D231N|PPP1CA_ENST00000532446.1_5'UTR|PPP1CA_ENST00000358239.4_Missense_Mutation_p.D176N	NM_001008709.1|NM_002708.3	NP_001008709.1|NP_002699.1	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha isozyme	220					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			ACGCCACGGTCGTTCTCGCCC	0.627000													23	86					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528889	20528889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20528889C>T	ENST00000315683.1	+	1	686	c.686C>T	c.(685-687)tCa>tTa	p.S229L		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		CCAAAAAAATCATCACATGGG	0.438000													49	133					0	0	1	0	0
CHSY1	22856	broad.mit.edu	37	15	101718571	101718571	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101718571G>A	ENST00000254190.3	-	3	1906	c.1431C>T	c.(1429-1431)ttC>ttT	p.F477F	CHSY1_ENST00000543813.1_5'UTR	NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	477					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGATTTTGCTGAAAGTCTGCT	0.488000													40	33					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84559348	84559348	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84559348C>T	ENST00000262753.4	-	14	1712		c.e14+1		POF1B_ENST00000373145.3_Splice_Site	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B								actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TCCTTTTATACCTCTGACTGA	0.403000													26	43					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8375235	8375235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8375235G>A	ENST00000538603.1	-	7	1136	c.578C>T	c.(577-579)tCc>tTc	p.S193F	FAM90A1_ENST00000307435.6_Missense_Mutation_p.S193F	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	193							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		ACTTGAGGAGGAGCTCAGACT	0.597000													23	90					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71150068	71150068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71150068C>T	ENST00000355527.3	-	7	964	c.688G>A	c.(688-690)Ggg>Agg	p.G230R	DHCR7_ENST00000407721.2_Missense_Mutation_p.G230R	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	230					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	AACCACTTCCCGATCCGAGGG	0.473000									Smith-Lemli-Opitz syndrome				21	50					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133895173	133895173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133895173C>T	ENST00000220616.4	+	8	1044	c.1004C>T	c.(1003-1005)cCc>cTc	p.P335L	TG_ENST00000377869.1_Missense_Mutation_p.P335L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	335	Thyroglobulin type-1 4.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ACGGAAGGGCCCTGCTGGTGT	0.607000													19	32					0	0	1	0	0
EPHX2	2053	broad.mit.edu	37	8	27348760	27348760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27348760G>A	ENST00000521400.1	+	1	465	c.35G>A	c.(34-36)gGg>gAg	p.G12E	EPHX2_ENST00000518379.1_Missense_Mutation_p.G12E|EPHX2_ENST00000517536.1_Missense_Mutation_p.G12E|EPHX2_ENST00000380476.3_5'UTR|EPHX2_ENST00000520666.1_3'UTR|EPHX2_ENST00000521780.1_5'UTR	NM_001979.5	NP_001970.2	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	12	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	27		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GACCTTGACGGGGTGCTGGCG	0.741000													5	8					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335524	20335524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20335524G>A	ENST00000302555.5	-	3	298	c.149C>T	c.(148-150)gCt>gTt	p.A50V	GP2_ENST00000341642.5_Intron|GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.A50V			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	50						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GGTGCCAGGAGCTCCGCAGTC	0.547000													12	57					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699764	48699764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48699764G>A	ENST00000544264.1	-	1	584	c.304C>T	c.(304-306)Cct>Tct	p.P102S	CELSR3_ENST00000164024.4_Missense_Mutation_p.P102S			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	102					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCTGCTCAGGGGGCCCTCGA	0.657000													65	160					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83129493	83129493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:83129493G>A	ENST00000329312.4	+	4	1814	c.1777G>A	c.(1777-1779)Gaa>Aaa	p.E593K		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	593					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TGAAAAAGGGGAAAAAGCAAG	0.423000													26	21					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46607818	46607818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:46607818C>T	ENST00000263734.3	+	12	2517	c.2007C>T	c.(2005-2007)ccC>ccT	p.P669P		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	669					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CGTTGGGGCCCCCTGTCTCTC	0.587000													45	118					0	0	1	0	0
SPATA8	145946	broad.mit.edu	37	15	97327486	97327486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:97327486G>A	ENST00000328504.3	+	2	460	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	SPATA8_ENST00000558553.1_Missense_Mutation_p.G24E	NM_173499.3	NP_775770.1	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	65										large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			GCCTGCAAAGGAAGGTAAGTA	0.577000													15	76					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22892266	22892266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22892266C>T	ENST00000543184.1	-	4	1697	c.835G>A	c.(835-837)Gag>Aag	p.E279K	PRAME_ENST00000398743.2_Missense_Mutation_p.E279K|PRAME_ENST00000402697.1_Missense_Mutation_p.E279K|PRAME_ENST00000398741.1_Missense_Mutation_p.E279K|PRAME_ENST00000405655.3_Missense_Mutation_p.E279K|PRAME_ENST00000539862.1_Missense_Mutation_p.E263K|PRAME_ENST00000424204.2_Missense_Mutation_p.E263K	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	279					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		TCTTCCTTCTCCGGGGAAATG	0.507000													34	81					0	0	1	0	0
CLLU1	574028	broad.mit.edu	37	12	92818597	92818597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:92818597G>A	ENST00000378485.1	+	1	863	c.141G>A	c.(139-141)ctG>ctA	p.L47L	CLLU1_ENST00000472839.2_Intron|CLLU1OS_ENST00000538965.1_Intron|CLLU1OS_ENST00000378487.2_Intron|RP11-693J15.4_ENST00000508671.1_RNA	NM_001025233.1	NP_001020404.1			chronic lymphocytic leukemia up-regulated 1											NS(1)|breast(1)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	7						TAAATAAGCTGATTATTTATT	0.313000													13	35					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79387423	79387423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:79387423C>T	ENST00000370742.3	-	9	1195	c.1132G>A	c.(1132-1134)Gat>Aat	p.D378N		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	378	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTCATGGTATCAGGTGAGTAA	0.403000													14	99					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1616936	1616936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1616936C>T	ENST00000381580.1	-	3	726	c.547G>A	c.(547-549)Gac>Aac	p.D183N	SIRPG_ENST00000303415.3_Missense_Mutation_p.D216N|RP11-77C3.3_ENST00000456177.1_RNA|SIRPG_ENST00000216927.4_Missense_Mutation_p.D216N|SIRPG_ENST00000344103.4_Intron|SIRPG_ENST00000381583.2_Missense_Mutation_p.D216N			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	216	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						TCCCAGGGGTCCAGTACCACC	0.597000													34	86					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172479429	172479429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172479429G>A	ENST00000417960.1	+	8	1095	c.618G>A	c.(616-618)atG>atA	p.M206I	ECT2_ENST00000232458.5_Missense_Mutation_p.M207I|ECT2_ENST00000427830.1_Missense_Mutation_p.M207I|ECT2_ENST00000392692.3_Missense_Mutation_p.M238I|ECT2_ENST00000441497.2_Missense_Mutation_p.M207I|ECT2_ENST00000540509.1_Missense_Mutation_p.M238I	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	207	BRCT 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CTCCAATTATGAAGCCAGAAT	0.323000													38	93					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180569	124180569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124180569G>A	ENST00000357821.2	-	1	164	c.94C>T	c.(94-96)Ctg>Ttg	p.L32L		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TAGATTCCCAGGAACAGGAGG	0.483000													18	137					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51382663	51382663	+	Silent	SNP	G	G	A	rs151022264		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51382663G>A	ENST00000216392.7	-	10	1451	c.1119C>T	c.(1117-1119)ttC>ttT	p.F373F	PYGL_ENST00000532462.1_Silent_p.F373F|PYGL_ENST00000544180.2_Silent_p.F339F	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	373					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TGGTGTAGGCGAAGGTCTTCT	0.592000													11	60					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76811167	76811167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76811167G>A	ENST00000286719.7	-	5	716	c.360C>T	c.(358-360)tcC>tcT	p.S120S		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	120			S -> R.		detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GGAGTGGGAAGGAGAGGCGTG	0.522000													53	145					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269763	150269763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150269763G>A	ENST00000255945.2	+	3	780	c.605G>A	c.(604-606)aGg>aAg	p.R202K	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Missense_Mutation_p.R216K	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	202							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGGCCCAGAGGGCACAGTTG	0.547000													27	97					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1634338	1634338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1634338G>A	ENST00000426508.2	-	11	1602	c.1239C>T	c.(1237-1239)ttC>ttT	p.F413F	IFT140_ENST00000439987.2_5'UTR|LA16c-395F10.2_ENST00000563162.1_RNA	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	413										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				CTTGCTGGTGGAAGTGTGACG	0.607000													6	13					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39525587	39525587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39525587G>A	ENST00000265707.5	+	14	1442	c.1397G>A	c.(1396-1398)gGa>gAa	p.G466E	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.G442E	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	466	Disintegrin.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TACTGCAATGGAACCTCTAGT	0.393000													61	125					0	0	1	0	0
TMEFF2	23671	broad.mit.edu	37	2	193059173	193059173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:193059173G>A	ENST00000409056.3	-	1	77	c.78C>T	c.(76-78)ccC>ccT	p.P26P	TMEFF2_ENST00000392314.1_Silent_p.P26P|TMEFF2_ENST00000272771.5_Silent_p.P26P			Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two follistatin-like domains 2	26						extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			GTAGCATGACGGGCAGCAGCA	0.597000													27	72					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46096167	46096167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46096167C>T	ENST00000252934.5	+	4	662	c.397C>T	c.(397-399)Cgc>Tgc	p.R133C	ATXN10_ENST00000498009.1_3'UTR|ATXN10_ENST00000381061.4_Missense_Mutation_p.R69C	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	133					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		CTTAGCTTTTCGCTGTGGCCT	0.313000													15	32					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	336800	336800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:336800G>A	ENST00000343164.4	-	8	918	c.866C>T	c.(865-867)tCc>tTc	p.S289F	SLC6A13_ENST00000445055.2_Missense_Mutation_p.S197F	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	289					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GATGGCGAAGGAGAAGAATAT	0.567000													17	36					0	0	1	0	0
UBL4B	164153	broad.mit.edu	37	1	110655414	110655414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110655414G>A	ENST00000334179.3	+	1	353	c.258G>A	c.(256-258)caG>caA	p.Q86Q		NM_203412.1	NP_981957.1	Q8N7F7	UBL4B_HUMAN	ubiquitin-like 4B	86						cytoplasm				endometrium(1)|kidney(1)|large_intestine(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	7		all_cancers(81;1.14e-05)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0236)|all cancers(265;0.0823)|Epithelial(280;0.0917)|Colorectal(144;0.109)|LUSC - Lung squamous cell carcinoma(189;0.134)		ACCAGCCGCAGACCCAGCCCC	0.582000													21	110					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103126831	103126831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103126831G>A	ENST00000428762.1	-	61	9955	c.9796C>T	c.(9796-9798)Ccc>Tcc	p.P3266S	RELN_ENST00000424685.2_Missense_Mutation_p.P3266S|RELN_ENST00000343529.5_Missense_Mutation_p.P3266S|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3266					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATATAACTGGGAAGGTCGTGA	0.463000													23	53					0	0	1	0	0
S100Z	170591	broad.mit.edu	37	5	76173582	76173582	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76173582C>T	ENST00000317593.4	+	4	457	c.225C>T	c.(223-225)ttC>ttT	p.F75F	S100Z_ENST00000513010.1_Silent_p.F75F	NM_130772.3	NP_570128.2	Q8WXG8	S100Z_HUMAN	S100 calcium binding protein Z	75	EF-hand 2.						calcium ion binding			large_intestine(1)|ovary(1)	2		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;8.91e-51)|Epithelial(54;5.43e-45)|all cancers(79;1.82e-40)		TTAATGAATTCGTGGTCATGG	0.378000													7	75					0	0	1	0	0
HBM	3042	broad.mit.edu	37	16	216426	216426	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:216426G>A	ENST00000356815.3	+	2	272	c.252G>A	c.(250-252)gcG>gcA	p.A84A	HBM_ENST00000472539.1_3'UTR	NM_001003938.3	NP_001003938.1	Q6B0K9	HBM_HUMAN	hemoglobin, mu	84						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;1.62e-06)|all_epithelial(16;4.01e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				GCCCGCTGGCGGACCTGCACG	0.746000													4	7					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28996799	28996799	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:28996799C>T	ENST00000322982.3	-	0	1135							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GCTGGCTCAGCCGATTACCCT	0.692000													3	16					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28649024	28649024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28649024C>T	ENST00000280904.6	-	15	2787	c.2344G>A	c.(2344-2346)Gag>Aag	p.E782K	DSC2_ENST00000251081.6_Missense_Mutation_p.E782K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	782					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCGATGGTCTCCTGACCTCCG	0.567000													23	48					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18869133	18869133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18869133G>A	ENST00000406451.3	+	19	2569	c.2419G>A	c.(2419-2421)Gac>Aac	p.D807N	HDAC9_ENST00000401921.1_Missense_Mutation_p.D766N|HDAC9_ENST00000441542.2_Missense_Mutation_p.D810N|HDAC9_ENST00000432645.2_Missense_Mutation_p.D807N	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	807	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	ATACTTGAGAGACCAACTAAA	0.378000													26	48					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57611049	57611049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57611049G>A	ENST00000371236.2	-	3	384	c.121C>T	c.(121-123)Cgg>Tgg	p.R41W	DAB1_ENST00000420954.2_Missense_Mutation_p.R41W|DAB1_ENST00000439789.2_Missense_Mutation_p.R41W|DAB1_ENST00000371234.4_Missense_Mutation_p.R41W|DAB1_ENST00000371231.1_Missense_Mutation_p.R41W|DAB1_ENST00000414851.2_Missense_Mutation_p.R41W|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371230.1_Missense_Mutation_p.R41W			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	41	PID.				cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCTTTGTACCGGACCCCTTCA	0.443000													36	99					0	0	1	0	0
SFXN2	118980	broad.mit.edu	37	10	104495636	104495636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104495636C>T	ENST00000369893.4	+	11	1006	c.839C>T	c.(838-840)cCa>cTa	p.P280L		NM_178858.4	NP_849189.1	Q96NB2	SFXN2_HUMAN	sideroflexin 2	280					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|prostate(1)	13		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		TTCATGGTGCCAGTGGCGTGT	0.542000													11	130					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124739717	124739717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124739717G>A	ENST00000311127.4	-	4	1238	c.1171C>T	c.(1171-1173)Cca>Tca	p.P391S		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	391						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						TCATCCCCTGGATTCCCAGTT	0.448000													19	52					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107267485	107267485	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107267485C>T	ENST00000334726.2	+	1	1031	c.942C>T	c.(940-942)ttC>ttT	p.F314F		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATACTGCCTTCATTTCCATCC	0.338000													17	52					0	0	1	0	0
PRNT	149830	broad.mit.edu	37	20	4713310	4713310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:4713310G>A	ENST00000326539.2	-	2	950	c.13C>T	c.(13-15)Ctt>Ttt	p.L5F	PRNT_ENST00000418528.1_Missense_Mutation_p.L5F|PRNT_ENST00000423718.2_Missense_Mutation_p.L5F														p.L5F(2)		endometrium(2)|lung(5)	7						aagaaaacaagactatgctgc	0.488000													6	12					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55432786	55432786	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55432786C>T	ENST00000314259.3	+	1	173	c.144C>T	c.(142-144)atC>atT	p.I48I		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TAACTATTATCACAAGTCAGA	0.408000													23	219					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70355236	70355236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70355236G>A	ENST00000305107.6	-	3	969	c.923C>T	c.(922-924)tCt>tTt	p.S308F	UGT2B4_ENST00000512583.1_Missense_Mutation_p.S308F|UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000381096.3_Missense_Mutation_p.S172F	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	308					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						CGACCCCAGAGAAAACACCAC	0.393000													83	209					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130286178	130286178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130286178G>A	ENST00000257359.6	-	4	1850	c.1144C>T	c.(1144-1146)Ctc>Ttc	p.L382F		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	382	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GGCCCGAAGAGCCGTGTGCAG	0.672000													3	6					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404038	20404038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20404038C>T	ENST00000285600.4	+	1	272	c.213C>T	c.(211-213)atC>atT	p.I71I		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TCATTGATATCTGTCAGTCTA	0.393000													53	127					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156937867	156937867	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156937867G>A	ENST00000368194.3	-	11	1914	c.875C>T	c.(874-876)cCt>cTt	p.P292L	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.P252L	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	252					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGAGGTTCGAGGACTGTCTAG	0.567000													30	31					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143018840	143018840	+	Missense_Mutation	SNP	C	C	T	rs143506735		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143018840C>T	ENST00000343257.2	+	5	682	c.595C>T	c.(595-597)Cgt>Tgt	p.R199C	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	199					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GACAATACTTCGTGGGGTTGT	0.507000													21	58					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784745	30784745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30784745G>A	ENST00000246229.4	-	3	1265	c.1001C>T	c.(1000-1002)tCc>tTc	p.S334F		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	334						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTGAGCTGGGGAAGAGATAGG	0.557000													14	143					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922597	24922597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922597C>T	ENST00000329468.2	+	1	2057	c.1583C>T	c.(1582-1584)tCc>tTc	p.S528F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCTCCTCTTTCCTTCCTGACT	0.532000													81	213					0	0	1	0	0
GTPBP10	85865	broad.mit.edu	37	7	90007497	90007497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:90007497C>T	ENST00000222511.6	+	8	815	c.749C>T	c.(748-750)gCt>gTt	p.A250V	GTPBP10_ENST00000257659.8_Missense_Mutation_p.A171V	NM_033107.3	NP_149098.2	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 (putative)	250					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(4)	10						TACAGGACAGCTTTTGAAACC	0.323000													19	34					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38775237	38775237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:38775237C>T	ENST00000308973.4	-	4	2580	c.1975G>A	c.(1975-1977)Gaa>Aaa	p.E659K	TLR10_ENST00000508334.1_Missense_Mutation_p.E659K|TLR10_ENST00000361424.2_Missense_Mutation_p.E659K|TLR10_ENST00000506111.1_Missense_Mutation_p.E659K	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	659	TIR.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						GAACCATCTTCCTTCTCTAGA	0.368000													26	71					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23080766	23080766	+	Missense_Mutation	SNP	G	G	A	rs138556206		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23080766G>A	ENST00000219689.7	-	16	2659	c.2660C>T	c.(2659-2661)tCg>tTg	p.S887L	USP31_ENST00000567975.1_Missense_Mutation_p.S180L	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	887	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GTGAATTGGCGAATCCCCTGA	0.517000													4	33					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58598338	58598338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58598338C>T	ENST00000240727.6	-	5	1079	c.680G>A	c.(679-681)gGg>gAg	p.G227E	ZSCAN18_ENST00000600404.1_Missense_Mutation_p.G283E|ZSCAN18_ENST00000601144.1_Missense_Mutation_p.G227E|ZSCAN18_ENST00000421612.2_Missense_Mutation_p.G92E	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	227					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCCCCACTCCCCCAGGTGCTG	0.642000													10	48					0	0	1	0	0
CHST13	166012	broad.mit.edu	37	3	126261247	126261247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126261247C>T	ENST00000319340.2	+	3	902	c.852C>T	c.(850-852)tcC>tcT	p.S284S		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	284					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		CGGGCGCATCCGACCTGAGCT	0.746000													5	7					0	0	1	0	0
SPACA1	81833	broad.mit.edu	37	6	88769219	88769219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88769219G>A	ENST00000237201.1	+	5	640	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K	SPACA1_ENST00000462690.1_3'UTR	NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	175						integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		AGTACGCAAGGAAAGTCACCC	0.343000													9	44					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78432425	78432425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:78432425G>A	ENST00000370767.1	-	7	513	c.426C>T	c.(424-426)ggC>ggT	p.G142G	FUBP1_ENST00000436586.2_Silent_p.G163G|FUBP1_ENST00000370768.2_Silent_p.G142G			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	142	KH 1.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						TTTCTGGAAGGCCACCACTGT	0.323000			"""F, N"""		oligodendroglioma								20	43					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1235690	1235690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1235690C>T	ENST00000324642.3	+	4	657	c.534C>T	c.(532-534)tcC>tcT	p.S178S	SLC6A18_ENST00000296821.4_Silent_p.S178S	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	178					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACAGTGGCTCCATCCAGTGGT	0.572000													40	95					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43777406	43777406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43777406C>T	ENST00000389420.3	-	31	4751	c.4752G>A	c.(4750-4752)agG>agA	p.R1584R		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1584	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAGGAGGGTTCCTGCAATTCT	0.378000													7	29					0	0	1	0	0
BNIP3P1	319138	broad.mit.edu	37	14	28733809	28733809	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:28733809C>T	ENST00000550043.1	+	0	214																											CTGCAGGGCTCCTGGGTAGAA	0.587000													5	36					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77415293	77415293	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77415293C>T	ENST00000451710.3	-	17	2352	c.2115G>A	c.(2113-2115)tcG>tcA	p.S705S	TRPM6_ENST00000376864.4_Silent_p.S705S|TRPM6_ENST00000361255.3_Silent_p.S700S|TRPM6_ENST00000360774.1_Silent_p.S705S|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Silent_p.S700S			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	705					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TAAGGCAGGTCGAATTGCTCC	0.512000													20	59					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60886272	60886272	+	Missense_Mutation	SNP	C	C	T	rs112963711	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60886272C>T	ENST00000252999.3	-	73	10100	c.10034G>A	c.(10033-10035)gGt>gAt	p.G3345D		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3345	Laminin G-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACAGGGAACCCCCAAACTG	0.701000													14	52					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111769563	111769563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111769563G>A	ENST00000452346.2	+	9	1139	c.1136G>A	c.(1135-1137)gGg>gAg	p.G379E	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.G253E			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	379	CUB 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GGCTTTGAAGGGAAAATTTCA	0.403000													79	213					0	0	1	0	0
CSAD	51380	broad.mit.edu	37	12	53552405	53552405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53552405G>A	ENST00000267085.4	-	17	1686	c.1453C>T	c.(1453-1455)Cac>Tac	p.H485Y	CSAD_ENST00000379846.1_Missense_Mutation_p.H311Y|CSAD_ENST00000453446.2_Missense_Mutation_p.H458Y|CSAD_ENST00000379843.3_Missense_Mutation_p.H311Y|CSAD_ENST00000444623.1_Missense_Mutation_p.H458Y	NM_001244706.1|NM_015989.4	NP_001231635.1|NP_057073.4	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	458					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(4)	14					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CGGGTCCCGTGGGGCTGGTAG	0.612000													9	28					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65621788	65621788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65621788C>T	ENST00000327987.4	-	13	2396	c.2145G>A	c.(2143-2145)aaG>aaA	p.K715K		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	715										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GCTCCAGCTCCTTCATATCCA	0.657000													88	130					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41161795	41161795	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41161795C>T	ENST00000263413.3	-	10	1722	c.1458_splice	c.e10+1	p.E486_splice	C6_ENST00000337836.5_Splice_Site_p.E486_splice|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	486	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTACTCTTACCTCAAAGTCAA	0.398000													25	92					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229372	140229372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140229372G>A	ENST00000378122.3	+	1	2016	c.1292G>A	c.(1291-1293)gGc>gAc	p.G431D	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.G431D|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGACGGGGGCTCGCCTTCA	0.632000													14	87					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995875	19995875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:19995875C>T	ENST00000391403.2	-	1	2003	c.1900G>A	c.(1900-1902)Gat>Aat	p.D634N		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	634						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TCTTTGGTATCATTTCTACTG	0.433000													88	229					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40254023	40254023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40254023C>T	ENST00000263791.5	+	7	825	c.782C>T	c.(781-783)tCt>tTt	p.S261F	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.S261F|EIF2AK4_ENST00000559624.1_Missense_Mutation_p.S261F	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	261					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGTGAAGATTCTCCTGGCTCT	0.323000													31	75					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25718530	25718530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:25718530C>T	ENST00000349320.3	-	6	929	c.541G>A	c.(541-543)Gat>Aat	p.D181N	RHCE_ENST00000455194.1_Intron|RHCE_ENST00000425135.1_Missense_Mutation_p.D197N|RHCE_ENST00000374352.2_Missense_Mutation_p.D181N|RHCE_ENST00000413854.1_Missense_Mutation_p.D197N|RHCE_ENST00000346452.4_Intron|RHCE_ENST00000349438.4_Missense_Mutation_p.D197N|RHCE_ENST00000340849.4_Intron|RHCE_ENST00000243186.6_Missense_Mutation_p.D197N|RHCE_ENST00000294413.7_Missense_Mutation_p.D197N			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	197						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		TGATCATTATCCTCCGTTCCC	0.537000													39	104					0	0	1	0	0
HOOK1	51361	broad.mit.edu	37	1	60330893	60330893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60330893C>T	ENST00000371208.3	+	18	1977	c.1720C>T	c.(1720-1722)Ctt>Ttt	p.L574F	HOOK1_ENST00000395561.2_Missense_Mutation_p.L532F|HOOK1_ENST00000465876.1_Intron	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1	574					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					CATTGAAGATCTTCAGCCAGA	0.373000													19	60					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113549986	113549986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113549986C>T	ENST00000416899.2	+	12	1897	c.1771C>T	c.(1771-1773)Ccc>Tcc	p.P591S	MUSK_ENST00000374448.4_Missense_Mutation_p.P599S|MUSK_ENST00000189978.5_Missense_Mutation_p.P599S|MUSK_ENST00000374438.1_Missense_Mutation_p.P115S			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	599	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						AGGCTTACTTCCCTATGAACC	0.443000													9	23					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	12989982	12989982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:12989982G>A	ENST00000399002.2	+	1	341	c.67G>A	c.(67-69)Ggc>Agc	p.G23S	SPTLC3_ENST00000378194.4_Missense_Mutation_p.G23S|SPTLC3_ENST00000476791.1_3'UTR	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	23					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	ACAGAGCAATGGCTCACAAAG	0.483000													17	85					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83023654	83023654	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83023654C>T	ENST00000307792.3	-	13	1926	c.1458_splice	c.e13-1	p.D487_splice	SEMA3E_ENST00000427262.1_Splice_Site_p.D427_splice	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	487	Sema.				axon guidance	extracellular space|membrane	receptor activity	p.D487Y(1)		breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GGAACTGGATCCTGAAATTTT	0.318000													16	38					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89157152	89157152	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89157152C>T	ENST00000452230.1	-	0	39				IGKC_ENST00000390237.2_RNA|AC096579.7_ENST00000430694.1_RNA																							TTCAACTGCTCATCAGATGGC	0.488000													6	12					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113512583	113512583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113512583C>T	ENST00000487903.1	+	22	2734	c.2646C>T	c.(2644-2646)ctC>ctT	p.L882L	ATP11A_ENST00000375645.3_Silent_p.L882L|ATP11A_ENST00000375630.2_Silent_p.L882L|ATP11A_ENST00000283558.8_Silent_p.L882L			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	882					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCTCTGAGCTCGTGCAGTACT	0.507000													12	55					0	0	1	0	0
BEND2	139105	broad.mit.edu	37	X	18192171	18192171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:18192171C>T	ENST00000380033.4	-	12	2092	c.1960G>A	c.(1960-1962)Gag>Aag	p.E654K	BEND2_ENST00000380030.3_Missense_Mutation_p.E563K	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	654										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						CCAGGTTCCTCTGGATTATCA	0.378000													20	13					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7677065	7677065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7677065G>A	ENST00000446248.2	+	13	1868	c.1767G>A	c.(1765-1767)gtG>gtA	p.V589V	CAMSAP3_ENST00000160298.4_Silent_p.V562V	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	562					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						ACTCCGAGGTGAAAATGACCA	0.672000													7	13					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67912443	67912443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67912443C>T	ENST00000358933.5	+	10	1332	c.1093C>T	c.(1093-1095)Cct>Tct	p.P365S	EDC4_ENST00000574770.1_3'UTR	NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	365					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TTGCAGTGTCCCTTTCTGGAG	0.562000													35	84					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115168320	115168320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115168320C>T	ENST00000393274.1	-	4	911	c.286G>A	c.(286-288)Gaa>Aaa	p.E96K	DENND2C_ENST00000393277.1_Missense_Mutation_p.E96K|DENND2C_ENST00000393276.3_Missense_Mutation_p.E96K	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	96										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCTTATTTTCATTCTCACTT	0.343000													35	98					0	0	1	0	0
C10orf137	26098	broad.mit.edu	37	10	127409777	127409777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:127409777C>T	ENST00000337623.3	+	2	218	c.113C>T	c.(112-114)tCa>tTa	p.S38L	C10orf137_ENST00000356792.4_Missense_Mutation_p.S38L	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AATTAGGGATCAGCTTTATTT	0.398000													35	97					0	0	1	0	0
CPNE1	8904	broad.mit.edu	37	20	34215285	34215285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34215285G>A	ENST00000317619.3	-	16	1547	c.1153C>T	c.(1153-1155)Ctc>Ttc	p.L385F	CPNE1_ENST00000397443.1_Missense_Mutation_p.L385F|CPNE1_ENST00000397445.1_Missense_Mutation_p.L385F|CPNE1_ENST00000397446.1_Missense_Mutation_p.L385F|CPNE1_ENST00000352393.4_Missense_Mutation_p.L385F|CPNE1_ENST00000397442.1_Missense_Mutation_p.L385F|CPNE1_ENST00000317677.5_Missense_Mutation_p.L390F			Q99829	CPNE1_HUMAN	copine I	385	VWFA.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GGGCCATAGAGGCGAACTTGG	0.577000													25	64					0	0	1	0	0
DOK5	55816	broad.mit.edu	37	20	53266970	53266970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:53266970G>A	ENST00000262593.5	+	8	1223	c.873G>A	c.(871-873)ctG>ctA	p.L291L	DOK5_ENST00000395939.1_Silent_p.L183L	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	291							insulin receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			CCAGCCCTCTGAAGCTTCATC	0.393000													22	44					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711904	20711904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20711904G>A	ENST00000315409.2	+	1	1007	c.954G>A	c.(952-954)atG>atA	p.M318I		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	318					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		TGTTTGGAATGAGAATTCGTC	0.393000													27	54					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763148	92763148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92763148C>T	ENST00000318238.4	-	5	3353	c.2137G>A	c.(2137-2139)Gac>Aac	p.D713N	SAMD9L_ENST00000411955.1_Missense_Mutation_p.D713N|SAMD9L_ENST00000437805.1_Missense_Mutation_p.D713N	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	713										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TCATAACTGTCCCTTTTAACA	0.343000													43	72					0	0	1	0	0
NLRP6	171389	broad.mit.edu	37	11	284265	284265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:284265G>A	ENST00000534750.1	+	6	2439	c.2234G>A	c.(2233-2235)cGa>cAa	p.R745Q	NLRP6_ENST00000312165.5_Missense_Mutation_p.R746Q	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	746						cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCGGTCTGCCGAGACCTTTCT	0.632000													11	31					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143958475	143958475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143958475C>T	ENST00000292427.4	-	3	591	c.559G>A	c.(559-561)Gac>Aac	p.D187N	CYP11B1_ENST00000517471.1_Missense_Mutation_p.D187N|CYP11B1_ENST00000377675.3_Missense_Mutation_p.D258N	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	187					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GGCTGGACGTCCAGGGTCAGG	0.637000									Familial Hyperaldosteronism type I				9	19					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241468740	241468740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241468740G>A	ENST00000391987.1	-	5	766	c.400C>T	c.(400-402)Ctc>Ttc	p.L134F	ANKMY1_ENST00000405002.1_Intron|ANKMY1_ENST00000272972.3_Missense_Mutation_p.L134F|ANKMY1_ENST00000462004.1_Intron|ANKMY1_ENST00000361678.4_Intron|ANKMY1_ENST00000536462.1_Intron|ANKMY1_ENST00000403283.1_Intron|ANKMY1_ENST00000373318.2_Intron|ANKMY1_ENST00000401804.1_Missense_Mutation_p.L223F|ANKMY1_ENST00000406958.1_Intron|ANKMY1_ENST00000373320.4_Intron|ANKMY1_ENST00000405523.3_Intron			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	134							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TCTTCTGAGAGGCTGATCCTG	0.542000													16	46					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129921147	129921147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129921147G>A	ENST00000368654.3	-	4	660	c.285C>T	c.(283-285)ttC>ttT	p.F95F	MKI67_ENST00000368653.3_Silent_p.F95F	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	95					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTACCTACCTGAAGGAACGAT	0.353000													8	44					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8221758	8221758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8221758G>A	ENST00000361926.3	+	10	1868	c.1758G>A	c.(1756-1758)aaG>aaA	p.K586K	AC135178.7_ENST00000458568.1_RNA|ARHGEF15_ENST00000421050.1_Silent_p.K586K	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	586	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						ATGCCCAGAAGGCCCTGGGTG	0.632000													45	48					0	0	1	0	0
STMN2	11075	broad.mit.edu	37	8	80567198	80567198	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:80567198C>T	ENST00000220876.7	+	4	763	c.381C>T	c.(379-381)ttC>ttT	p.F127F	STMN2_ENST00000518491.1_Silent_p.F116F|STMN2_ENST00000518111.1_Silent_p.F127F	NM_001199214.1|NM_007029.3	NP_001186143.1|NP_008960.2	Q93045	STMN2_HUMAN	stathmin-like 2	127					intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			ACAACAACTTCAGCAAGATGG	0.478000													20	43					0	0	1	0	0
FUT9	10690	broad.mit.edu	37	6	96651377	96651377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:96651377G>A	ENST00000302103.5	+	3	672	c.346G>A	c.(346-348)Gat>Aat	p.D116N		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	116					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CATCAGTTGGGATCTGACAAA	0.463000													16	30					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573667	140573667	+	Silent	SNP	C	C	T	rs17844573		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140573667C>T	ENST00000239446.4	+	1	1726	c.1542C>T	c.(1540-1542)ttC>ttT	p.F514F		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		514	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCACCTGTTCGCCCTCAGGT	0.701000													51	316					0	0	1	0	0
CHST11	50515	broad.mit.edu	37	12	105151002	105151002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:105151002C>T	ENST00000303694.5	+	3	919	c.480C>T	c.(478-480)aaC>aaT	p.N160N	CHST11_ENST00000549260.1_Silent_p.N155N	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	160					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						TCTCCGCCAACCTGAAGACCC	0.582000													17	54					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88474181	88474181	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:88474181A>G	ENST00000324166.5	+	2	1938	c.247A>G	c.(247-249)Aga>Gga	p.R83G	THNSL2_ENST00000343544.4_Missense_Mutation_p.R83G|THNSL2_ENST00000358591.2_Missense_Mutation_p.R83G|THNSL2_ENST00000377254.3_Missense_Mutation_p.R83G|THNSL2_ENST00000449349.1_Missense_Mutation_p.R51G|THNSL2_ENST00000402102.1_Missense_Mutation_p.R83G	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	83					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						AGCCTTCAGCAGATTCCGTCA	0.517000													33	85					0	0	1	0	0
TMEM74B	55321	broad.mit.edu	37	20	1162161	1162161	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1162161C>A	ENST00000381894.3	-	2	773	c.102G>T	c.(100-102)aaG>aaT	p.K34N	TMEM74B_ENST00000481747.1_5'UTR	NM_018354.1	NP_060824.1	Q9NUR3	CT046_HUMAN	transmembrane protein 74B	34						integral to membrane	protein binding										TGCTCAGTGTCTTCAGTTCCA	0.587000													4	52					0.00024832	0.000248652	1	1	0
MYO3A	53904	broad.mit.edu	37	10	26434399	26434399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26434399C>T	ENST00000265944.5	+	22	2607	c.2441C>T	c.(2440-2442)tCa>tTa	p.S814L	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	814	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AACCTGAAATCACAATACTTC	0.323000													11	49					0	0	1	0	0
SERINC5	256987	broad.mit.edu	37	5	79441966	79441966	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79441966G>A	ENST00000507668.2	-	11	1335	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F	SERINC5_ENST00000512972.2_Silent_p.F395F|SERINC5_ENST00000509193.1_Silent_p.F393F|SERINC5_ENST00000512721.1_Silent_p.F395F	NM_001174071.1|NM_178276.5	NP_001167542.1|NP_840060.1	Q86VE9	SERC5_HUMAN	serine incorporator 5	395					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|kidney(1)|lung(3)|ovary(1)	8		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GGAAGAACACGAAGTGGAAGT	0.488000													25	173					0	0	1	0	0
SLC17A9	63910	broad.mit.edu	37	20	61588800	61588800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61588800G>A	ENST00000370349.3	+	4	451	c.247G>A	c.(247-249)Ggt>Agt	p.G83S	SLC17A9_ENST00000370351.4_Missense_Mutation_p.G89S|SLC17A9_ENST00000488738.1_3'UTR			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	89					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						CAGGATTGGGGGTGAGAAGGT	0.642000													25	55					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810761	65810761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65810761G>A	ENST00000312006.4	-	3	794	c.513C>T	c.(511-513)gcC>gcT	p.A171A	GAL3ST3_ENST00000527878.1_Silent_p.A171A	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	171					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						CGCGCCGGAAGGCCGGGCAGT	0.662000													6	25					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104835967	104835967	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104835967C>T	ENST00000369878.3	+	7	2482	c.2358C>T	c.(2356-2358)ctC>ctT	p.L786L	CNNM2_ENST00000475511.1_3'UTR|CNNM2_ENST00000433628.2_Silent_p.L764L|CNNM2_ENST00000457502.2_Silent_p.L544L	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	786					ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ATTCTTCGCTCCTCCAAGTCT	0.537000													6	13					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57032929	57032929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57032929G>A	ENST00000262030.3	-	9	1500	c.1450C>T	c.(1450-1452)Ctg>Ttg	p.L484L	ATP5B_ENST00000552919.1_Silent_p.L473L	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	484					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GTCTCCTTCAGGGGTACCAGC	0.483000													69	108					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40689437	40689437	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40689437G>A	ENST00000298910.7	+	23	3145	c.3087G>A	c.(3085-3087)caG>caA	p.Q1029Q	LRRK2_ENST00000343742.2_Silent_p.Q1029Q	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1029					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTCCACAACAGCTATGTGAAG	0.338000													19	27					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54147547	54147547	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:54147547C>T	ENST00000265572.3	-	3	679	c.382G>A	c.(382-384)Gat>Aat	p.D128N	RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000524278.1_Missense_Mutation_p.D39N|OPRK1_ENST00000520287.1_Missense_Mutation_p.D128N	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	128					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CACAGCACATCCCCAAAAGGC	0.438000													42	77					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794844	126794844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126794844C>T	ENST00000373615.4	+	5	1818	c.1079C>T	c.(1078-1080)cCc>cTc	p.P360L		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	360						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						TCGCTCAGCCCCTCCAGCACG	0.657000													15	37					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169390881	169390881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169390881G>A	ENST00000545005.1	-	4	1295	c.788C>T	c.(787-789)tCt>tTt	p.S263F	CCDC181_ENST00000367805.3_Missense_Mutation_p.S263F|CCDC181_ENST00000491570.1_5'UTR|CCDC181_ENST00000367806.3_Missense_Mutation_p.S263F					coiled-coil domain containing 181																		GCCACTGACAGAGGAGTTGGA	0.458000													27	198					0	0	1	0	0
NOC2L	26155	broad.mit.edu	37	1	888594	888594	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:888594G>A	ENST00000327044.6	-	9	1012	c.963C>T	c.(961-963)tgC>tgT	p.C321C		NM_015658.3	NP_056473.2	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog (S. cerevisiae)	321						nucleolus	protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	16	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		TCTTGTGCCGGCAGACTCTGC	0.582000													4	43					0	0	1	0	0
CYP2F1	1572	broad.mit.edu	37	19	41628764	41628764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41628764C>T	ENST00000331105.2	+	7	932	c.860C>T	c.(859-861)aCc>aTc	p.T287I		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	287					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						CACATGGATACCCTGCTGATG	0.562000													15	45					0	0	1	0	0
GH2	2689	broad.mit.edu	37	17	61958450	61958450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61958450G>A	ENST00000332800.7	-	3	363	c.230C>T	c.(229-231)tCc>tTc	p.S77F	GH2_ENST00000449787.2_Missense_Mutation_p.S62F|GH2_ENST00000423893.2_Missense_Mutation_p.S77F|GH2_ENST00000456543.2_Missense_Mutation_p.S77F	NM_002059.4|NM_022557.3|NM_022558.3	NP_002050.1|NP_072051.1|NP_072052.1	P01242	SOM2_HUMAN	growth hormone 2	77						extracellular region	hormone activity			breast(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	24						GAAGCAGAGGGAGGTCTGGGG	0.532000													108	285					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20915652	20915652	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20915652G>A	ENST00000375071.3	+	1	212	c.30G>A	c.(28-30)ctG>ctA	p.L10L	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	10					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	CCTGCACCCTGAAGCCTGAGT	0.652000													13	72					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53679563	53679563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:53679563G>A	ENST00000262135.4	-	17	2750	c.2657C>T	c.(2656-2658)tCg>tTg	p.S886L	RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.S886L|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.S886L|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.S886L	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	886					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				ATGTGCCAACGAAATCAGAGG	0.328000													15	40					0	0	1	0	0
HAMP	57817	broad.mit.edu	37	19	35773543	35773543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35773543G>A	ENST00000598398.1	+	2	359	c.63G>A	c.(61-63)ctG>ctA	p.L21L	HAMP_ENST00000222304.3_Silent_p.L21L	NM_021175.2	NP_066998.1	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide	21					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TCGCCAGCCTGACCAGTGGCT	0.642000													64	125					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38451424	38451424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38451424G>A	ENST00000322350.5	+	19	2897	c.2551G>A	c.(2551-2553)Gga>Aga	p.G851R	EGFLAM_ENST00000397210.3_5'UTR|EGFLAM_ENST00000336740.6_Missense_Mutation_p.G617R|EGFLAM_ENST00000514476.1_5'UTR|EGFLAM_ENST00000506135.1_5'UTR|EGFLAM_ENST00000397202.2_Missense_Mutation_p.G217R|EGFLAM_ENST00000354891.3_Missense_Mutation_p.G859R	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	859	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					CAGGGTGTCAGGATCAAGATC	0.473000													46	170					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110413787	110413787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110413787C>T	ENST00000378402.5	+	14	1447	c.1343C>T	c.(1342-1344)tCa>tTa	p.S448L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	448					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACACAAAGATCAGATGATATT	0.333000										HNSCC(38;0.096)			8	37					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916090	42916090	+	Missense_Mutation	SNP	G	G	A	rs150584658		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42916090G>A	ENST00000316161.4	-	1	1543	c.1219C>T	c.(1219-1221)Cgc>Tgc	p.R407C	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Missense_Mutation_p.R407C|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	407					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		TTGAGGAAGCGATCGTACTTG	0.557000													66	186					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81969801	81969801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81969801C>T	ENST00000359376.3	+	27	3084	c.2870C>T	c.(2869-2871)tCc>tTc	p.S957F		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	957	PI-PLC Y-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						GAAATCCGCTCCTTTGTGGAG	0.483000													6	56					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81372178	81372178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81372178G>A	ENST00000398636.3	+	4	421	c.283G>A	c.(283-285)Ggc>Agc	p.G95S	SFTPA1_ENST00000428376.2_Missense_Mutation_p.G95S|SFTPA1_ENST00000372308.3_Missense_Mutation_p.G95S|SFTPA1_ENST00000419470.2_Missense_Mutation_p.G110S|SFTPA1_ENST00000372313.5_Missense_Mutation_p.G36S	NM_001164644.1|NM_001164646.1|NM_005411.4	NP_001158116.1|NP_001158118.1|NP_005402.3	Q8IWL2	SFTA1_HUMAN	surfactant protein A1	95	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TGGCGAGAGGGGCCCTCCAGG	0.612000													103	72					0	0	1	0	0
OTOS	150677	broad.mit.edu	37	2	241078664	241078664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241078664C>T	ENST00000391989.2	-	5	423	c.193G>A	c.(193-195)Gac>Aac	p.D65N	OTOS_ENST00000319460.1_Missense_Mutation_p.D65N			Q8NHW6	OTOSP_HUMAN	otospiralin	65						extracellular region				endometrium(2)|large_intestine(1)|lung(3)	6		all_epithelial(40;2.79e-15)|Breast(86;3.04e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|Hepatocellular(293;0.148)|all_hematologic(139;0.158)|Melanoma(123;0.16)		Epithelial(32;2.56e-30)|all cancers(36;7.18e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.37e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.07e-06)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		CGGGCCATGTCCTCGATCTGG	0.637000													29	77					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23116264	23116264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:23116264C>T	ENST00000397677.1	+	8	1628	c.980C>T	c.(979-981)gCt>gTt	p.A327V	CHMP7_ENST00000313219.7_Missense_Mutation_p.A327V|CHMP7_ENST00000520102.1_3'UTR	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	327					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GCCTACCAGGCTGGGGTAGGA	0.463000													7	29					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78400326	78400326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:78400326C>T	ENST00000397909.2	+	8	1181	c.1008C>T	c.(1006-1008)tcC>tcT	p.S336S	NAV3_ENST00000228327.6_Silent_p.S336S|NAV3_ENST00000536525.2_Silent_p.S336S|NAV3_ENST00000266692.7_Silent_p.S336S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	336						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.S336S(1)		NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GCAGCAAGTCCATGAATGTCA	0.562000										HNSCC(70;0.22)			29	64					0	0	1	0	0
IGHA2	3494	broad.mit.edu	37	14	106053911	106053911	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106053911G>A	ENST00000390539.2	-	0	607																											GATGTTGGCGGTTAGTGGGGT	0.612000													20	45					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120572392	120572392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120572392G>A	ENST00000300648.6	-	52	7159	c.7147C>T	c.(7147-7149)Ccc>Tcc	p.P2383S		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2383					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGAAGAGGGGGTCCACCTTA	0.627000													27	49					0	0	1	0	0
SENP8	123228	broad.mit.edu	37	15	72432292	72432292	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72432292C>T	ENST00000544411.1	+	3	815	c.328C>T	c.(328-330)Caa>Taa	p.Q110*	SENP8_ENST00000542035.2_Nonsense_Mutation_p.Q110*|SENP8_ENST00000340912.4_Nonsense_Mutation_p.Q110*|SENP8_ENST00000544171.1_Nonsense_Mutation_p.Q110*	NM_001172109.1|NM_001172110.1	NP_001165580.1|NP_001165581.1	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	110	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			breast(1)|kidney(2)|lung(1)|ovary(1)|skin(1)	6						GGTCTACCTCCAAGATAAAAA	0.443000													23	99					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8168563	8168563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8168563C>T	ENST00000600128.1	-	39	5236	c.4822G>A	c.(4822-4824)Gaa>Aaa	p.E1608K	FBN3_ENST00000601739.1_Missense_Mutation_p.E1608K|FBN3_ENST00000270509.2_Missense_Mutation_p.E1608K			Q75N90	FBN3_HUMAN	fibrillin 3	1608	EGF-like 25; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTGGAGCATTCGTCAATATCT	0.562000													13	35					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100686297	100686297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100686297C>T	ENST00000306151.4	+	3	11664	c.11600C>T	c.(11599-11601)tCa>tTa	p.S3867L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3867						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ATACGTATTTCAATTACCAGT	0.478000													51	92					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38764987	38764987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38764987C>T	ENST00000449082.2	-	18	3285	c.3286G>A	c.(3286-3288)Gaa>Aaa	p.E1096K		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1096					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ctcaggatttcctcaggatct	0.592000													11	31					0	0	1	0	0
MEOX2	4223	broad.mit.edu	37	7	15666539	15666539	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:15666539G>A	ENST00000262041.5	-	2	931	c.522C>T	c.(520-522)tcC>tcT	p.S174S		NM_005924.4	NP_005915.2	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	174					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TTCCTTCCTGGGAGTCTGAAA	0.363000													27	72					0	0	1	0	0
PLEK	5341	broad.mit.edu	37	2	68607929	68607929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:68607929C>T	ENST00000234313.7	+	3	452	c.273C>T	c.(271-273)gcC>gcT	p.A91A		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	91	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGAGAGATGCCTGGGTTCGGG	0.468000													68	143					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32189084	32189084	+	Missense_Mutation	SNP	C	C	T	rs149758111		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32189084C>T	ENST00000375023.3	-	4	608	c.470G>A	c.(469-471)cGg>cAg	p.R157Q		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	157	EGF-like 4.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						ACAGAAGTCCCGAAGCTGGCA	0.577000													20	34					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55145563	55145563	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55145563G>A	ENST00000414150.2	+	13	2504		c.e13-1		MROH7_ENST00000409996.1_Splice_Site|MROH7_ENST00000339553.5_Splice_Site|MROH7_ENST00000454855.2_Splice_Site|MROH7_ENST00000545244.1_Splice_Site|MROH7_ENST00000395690.2_Splice_Site|MROH7_ENST00000421030.2_Splice_Site					maestro heat-like repeat family member 7																		CTGTGCCCCAGATCCCAGAAA	0.657000													60	158					0	0	1	0	0
PPARA	5465	broad.mit.edu	37	22	46615854	46615854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46615854C>T	ENST00000396000.2	+	6	919	c.654C>T	c.(652-654)ttC>ttT	p.F218F	PPARA_ENST00000434345.2_Intron|PPARA_ENST00000402126.1_Silent_p.F218F|PPARA_ENST00000262735.5_Silent_p.F218F|PPARA_ENST00000407236.1_Silent_p.F218F			Q07869	PPARA_HUMAN	peroxisome proliferator-activated receptor alpha	218					fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	15		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	TGAAGAACTTCAACATGAACA	0.453000													4	40					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24460566	24460566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24460566C>T	ENST00000230036.1	-	12	1059	c.949G>A	c.(949-951)Gac>Aac	p.D317N		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	317						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						ATATTCCTGTCAACACTTTCA	0.373000													18	184					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211639	38211639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38211639C>T	ENST00000379705.3	-	11	3192	c.2335G>A	c.(2335-2337)Gaa>Aaa	p.E779K	TRPC4_ENST00000338947.5_Missense_Mutation_p.E606K|TRPC4_ENST00000358477.2_Missense_Mutation_p.E779K|TRPC4_ENST00000379681.3_Missense_Mutation_p.E784K|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379673.2_Missense_Mutation_p.E714K|TRPC4_ENST00000379679.1_Missense_Mutation_p.E606K|TRPC4_ENST00000355779.2_Intron			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	779	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TCACTCTTTTCATCTGAGTCT	0.423000													31	100					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37546855	37546855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:37546855G>A	ENST00000299824.1	+	11	1439	c.1250G>A	c.(1249-1251)cGa>cAa	p.R417Q	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.R375Q	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	417					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding	p.R417Q(1)		biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				AAGATCCCACGAGGTGAACTG	0.572000													46	184					0	0	1	0	0
NOMO2	283820	broad.mit.edu	37	16	18544465	18544465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:18544465G>A	ENST00000330537.6	-	12	1427	c.1257C>T	c.(1255-1257)ttC>ttT	p.F419F	NOMO2_ENST00000381474.3_Silent_p.F419F|NOMO2_ENST00000543392.1_Silent_p.F252F	NM_173614.2	NP_775885.1	Q5JPE7	NOMO2_HUMAN	NODAL modulator 2	419						endoplasmic reticulum membrane|integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(3)|lung(5)|ovary(3)|prostate(1)|skin(1)	20						CGGTGTCCGGGAAGCGAATGA	0.453000													35	154					0	0	1	0	0
LCN9	392399	broad.mit.edu	37	9	138557709	138557709	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138557709C>T	ENST00000277526.3	+	6	478	c.478C>T	c.(478-480)Ccc>Tcc	p.P160S	LCN9_ENST00000430290.2_3'UTR	NM_001001676.1	NP_001001676.1	Q8WX39	LCN9_HUMAN	lipocalin 9	160						extracellular region	pheromone binding|transporter activity			kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	6		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		CCTTCCAGATCCCTGCTACTC	0.692000													6	19					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52781677	52781677	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52781677G>A	ENST00000245457.5	+	1	565	c.411G>A	c.(409-411)tcG>tcA	p.S137S	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	137						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	GCTACCTCTCGATCGGGCACC	0.652000													14	140					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6125817	6125817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6125817G>A	ENST00000261405.5	-	30	5430	c.5176C>T	c.(5176-5178)Cgt>Tgt	p.R1726C		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1726	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding	p.R1726S(1)		NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TGAGTGAGACGAGGCCCTAAA	0.527000													22	68					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112358111	112358111	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112358111C>T	ENST00000206423.3	-	2	1595	c.642G>A	c.(640-642)ctG>ctA	p.L214L	CCDC80_ENST00000439685.2_Silent_p.L214L	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	214										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						GGCTAGGGTCCAGGGGCTGCT	0.582000													19	136					0	0	1	0	0
PIFO	128344	broad.mit.edu	37	1	111889590	111889590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111889590C>T	ENST00000369738.4	+	2	443	c.78C>T	c.(76-78)ttC>ttT	p.F26F	PIFO_ENST00000369737.4_Silent_p.F26F|PIFO_ENST00000484512.1_3'UTR	NM_181643.4	NP_857594.2			primary cilia formation																		TTCCTCACTTCCATCCCCCGA	0.493000													25	70					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75248565	75248565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75248565C>T	ENST00000325680.7	+	4	1943	c.1819C>T	c.(1819-1821)Cca>Tca	p.P607S	YLPM1_ENST00000238571.3_Intron|YLPM1_ENST00000552421.1_Missense_Mutation_p.P607S	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGTTCTTCCCCCACCATCTCT	0.597000													71	129					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515443	140515443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140515443C>T	ENST00000231134.5	+	1	644	c.427C>T	c.(427-429)Cca>Tca	p.P143S		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		143	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTAAAAATCCCAGAGAGCAC	0.443000													20	87					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140358575	140358575	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140358575G>A	ENST00000532602.1	+	2	3469	c.2436G>A	c.(2434-2436)ctG>ctA	p.L812L	PCDHA4_ENST00000512229.2_Silent_p.L809L|PCDHA5_ENST00000529859.1_Silent_p.L798L|PCDHA6_ENST00000529310.1_Silent_p.L812L|PCDHA7_ENST00000525929.1_Silent_p.L799L|PCDHA8_ENST00000531613.1_Silent_p.L812L|PCDHA5_ENST00000529619.1_Silent_p.L798L|PCDHA4_ENST00000530339.1_Silent_p.L809L|PCDHA6_ENST00000527624.1_Silent_p.L548L|PCDHAC2_ENST00000289269.5_Silent_p.L869L|PCDHA12_ENST00000398631.2_Silent_p.L803L|PCDHAC1_ENST00000253807.2_Silent_p.L825L|PCDHA10_ENST00000506939.2_Silent_p.L547L|PCDHA10_ENST00000307360.5_Silent_p.L810L|PCDHA1_ENST00000504120.2_Silent_p.L812L|PCDHA11_ENST00000398640.2_Silent_p.L811L|PCDHA13_ENST00000289272.2_Silent_p.L812L|PCDHA13_ENST00000409494.1_Silent_p.L812L|PCDHA3_ENST00000522353.2_Silent_p.L812L|PCDHA1_ENST00000394633.3_Silent_p.L548L|PCDHA2_ENST00000526136.1_Silent_p.L810L	NM_031857.1	NP_114063.1												p.L812L(6)|p.L810L(2)|p.L809L(1)|p.L547L(1)|p.L825L(1)|p.L799L(1)|p.L811L(1)|p.L803L(1)|p.L798L(1)|p.L869L(1)		breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCCTCCCTGAGAGCAGGCA	0.468000													15	73					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19654261	19654261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19654261C>T	ENST00000328041.6	+	9	927	c.730C>T	c.(730-732)Ctt>Ttt	p.L244F		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	244						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GTCTTTAGTCCTTGTGCTGAT	0.353000													23	59					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11231096	11231096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11231096C>T	ENST00000558518.1	+	14	2225	c.2038C>T	c.(2038-2040)Ctg>Ttg	p.L680L	LDLR_ENST00000545707.1_Intron|LDLR_ENST00000558013.1_Silent_p.L680L|LDLR_ENST00000535915.1_Silent_p.L639L|LDLR_ENST00000455727.2_Silent_p.L512L|LDLR_ENST00000557933.1_Silent_p.L680L	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	680	EGF-like 3.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CTGCCAGTATCTGTGCCTCCC	0.622000													15	72					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566468	136566468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136566468G>A	ENST00000264162.2	-	8	3459	c.3449C>T	c.(3448-3450)tCc>tTc	p.S1150F		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1150	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCAGCCCAGGGAGAACTGCAG	0.562000													39	60					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33840369	33840369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33840369C>T	ENST00000389232.4	+	9	849	c.779C>T	c.(778-780)gCc>gTc	p.A260V	RYR3_ENST00000415757.3_Missense_Mutation_p.A260V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	260	MIR 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGGACTCGAGCCAGGTCTCTT	0.512000													4	24					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167142880	167142880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167142880C>T	ENST00000375387.4	-	11	1911	c.1571G>A	c.(1570-1572)cGa>cAa	p.R524Q	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Missense_Mutation_p.R523Q|SCN9A_ENST00000409672.1_Missense_Mutation_p.R523Q|SCN9A_ENST00000303354.6_Missense_Mutation_p.R524Q			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	523						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R523L(1)		NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTCATGTGCTCGCCTATGCCC	0.438000													71	262					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131107735	131107735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131107735C>T	ENST00000300456.3	+	3	580	c.463C>T	c.(463-465)Ctc>Ttc	p.L155F	SLC27A4_ENST00000372870.1_Intron	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	155					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						GGAGGCAGCCCTCATCAACAC	0.647000													4	18					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27802752	27802752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27802752G>A	ENST00000408964.2	+	1	3364	c.3313G>A	c.(3313-3315)Gat>Aat	p.D1105N		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1105										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					AATACCCCCCGATGTGCCTCC	0.453000													24	103					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3142167	3142167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3142167G>A	ENST00000252463.2	-	2	469	c.382C>T	c.(382-384)Cga>Tga	p.R128*	ZSCAN10_ENST00000575108.1_5'UTR|ZSCAN10_ENST00000538082.2_Intron|ZSCAN10_ENST00000572548.1_Intron	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	128	Pro-rich.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						GGCTGGGGTCGGGGAGGCTCA	0.652000													15	39					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27134413	27134413	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27134413C>T	ENST00000343060.4	-	2	715	c.652_splice	c.e2-1	p.G218_splice	HOXA1_ENST00000355633.5_3'UTR	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	218						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CTCCAACTTTCCCTGGGGCAA	0.493000													26	42					0	0	1	0	0
FASLG	356	broad.mit.edu	37	1	172628472	172628472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:172628472G>A	ENST00000367721.2	+	1	315	c.131G>A	c.(130-132)aGg>aAg	p.R44K	FASLG_ENST00000340030.3_Missense_Mutation_p.R44K	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	44	Pro-rich.				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						GGTCAAAGGAGGccaccacca	0.657000													10	20					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6267018	6267018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6267018C>T	ENST00000264870.3	-	4	609	c.344G>A	c.(343-345)gGa>gAa	p.G115E		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	115					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GATGTAGGTTCCCTTGTTCTC	0.463000													59	124					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169632887	169632887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169632887G>A	ENST00000335742.7	+	10	1988	c.631G>A	c.(631-633)Ggc>Agc	p.G211S	PALLD_ENST00000261509.6_Missense_Mutation_p.G593S|PALLD_ENST00000512127.1_Missense_Mutation_p.G211S|PALLD_ENST00000505667.1_Missense_Mutation_p.G593S			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	593					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCCTGAGTTAGGCCTGAGCAG	0.512000									Pancreatic Cancer, Familial Clustering of				26	42					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73679476	73679476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73679476C>T	ENST00000339764.1	+	6	1444	c.693C>T	c.(691-693)ttC>ttT	p.F231F	RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000543947.1_Silent_p.F56F|DNAJB13_ENST00000537753.1_Silent_p.F56F	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	231					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					ACAACCTCTTCTTCGTGAACC	0.592000													16	32					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25005324	25005324	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25005324C>A	ENST00000382114.4	-	8	1572	c.1387G>T	c.(1387-1389)Ggg>Tgg	p.G463W		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	463						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				GTCATGGCCCCCCGGGATGGA	0.502000													53	186					1.38658e-30	1.3959e-30	1	1	0
COL5A3	50509	broad.mit.edu	37	19	10088273	10088273	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10088273G>A	ENST00000264828.3	-	42	3208	c.3123C>T	c.(3121-3123)tcC>tcT	p.S1041S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1041	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CACTTACCCGGGACCCCTTCT	0.642000													6	26					0	0	1	0	0
R3HCC1L	27291	broad.mit.edu	37	10	99968552	99968552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:99968552C>T	ENST00000298999.3	+	5	984	c.681C>T	c.(679-681)gtC>gtT	p.V227V	R3HCC1L_ENST00000314594.5_5'UTR|R3HCC1L_ENST00000370586.2_Intron|R3HCC1L_ENST00000370584.3_Silent_p.V227V	NM_014472.4	NP_055287.4			R3H domain and coiled-coil containing 1-like																		TTAGTTCTGTCATGAAACCTG	0.353000													33	59					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43749275	43749275	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43749275G>A	ENST00000263801.3	-	12	1768	c.1516C>T	c.(1516-1518)Cta>Tta	p.L506L	TP53BP1_ENST00000450115.2_Silent_p.L511L|TP53BP1_ENST00000382039.3_Silent_p.L511L|TP53BP1_ENST00000382044.4_Silent_p.L511L	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	506					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTCAAAGATAGCCCAAGATCC	0.403000								Other conserved DNA damage response genes					25	70					0	0	1	0	0
INPP5A	3632	broad.mit.edu	37	10	134579348	134579348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134579348C>T	ENST00000368594.3	+	12	1252	c.975C>T	c.(973-975)ccC>ccT	p.P325P	INPP5A_ENST00000368593.3_Silent_p.P325P	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	325					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CGTTCCCTCCCAGGTATGGAA	0.498000													19	55					0	0	1	0	0
DGCR6	8214	broad.mit.edu	37	22	18897764	18897764	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18897764G>A	ENST00000331444.6	+	3	503	c.351G>A	c.(349-351)gcG>gcA	p.A117A	DGCR6_ENST00000436645.1_3'UTR|DGCR6_ENST00000413981.1_5'UTR	NM_005675.4	NP_005666.2	Q14129	DGCR6_HUMAN	DiGeorge syndrome critical region gene 6	117			A -> V (in dbSNP:rs16983281).		cell adhesion|organ morphogenesis	nucleus|proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|upper_aerodigestive_tract(1)	3						TGCTTCAGGCGGCTCAGCAGC	0.672000													4	15					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29121194	29121194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29121194G>A	ENST00000261590.8	+	13	2127	c.1918G>A	c.(1918-1920)Ggc>Agc	p.G640S		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	640					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TTGCGGAAAGGGCGCCAAAGG	0.428000													27	71					0	0	1	0	0
RBM48	84060	broad.mit.edu	37	7	92164170	92164170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92164170C>T	ENST00000481551.1	+	4	944	c.903C>T	c.(901-903)aaC>aaT	p.N301N	RBM48_ENST00000265732.5_Silent_p.N301N			Q5RL73	CG064_HUMAN	RNA binding motif protein 48	301							nucleotide binding										TTCAAACAAACCCAACTGGTA	0.413000													18	40					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686601	54686601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54686601C>T	ENST00000540264.2	-	2	1188	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	NFE2_ENST00000312156.4_Missense_Mutation_p.E227K|NFE2_ENST00000435572.2_Missense_Mutation_p.E227K|RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000553070.1_Missense_Mutation_p.E227K			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	227					blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						GCCCGACGTTCATCCCGACTC	0.577000													14	24					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6476061	6476061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:6476061G>A	ENST00000297056.6	-	3	520	c.351C>T	c.(349-351)gcC>gcT	p.A117A	DAGLB_ENST00000428902.2_Intron|DAGLB_ENST00000425398.2_Silent_p.A117A|DAGLB_ENST00000479922.2_5'UTR|DAGLB_ENST00000421761.2_Intron|DAGLB_ENST00000436575.1_Silent_p.A76A	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta	117					lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CTGCCACCCAGGCAGCCCCCA	0.542000													66	120					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50290710	50290710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50290710G>A	ENST00000338821.5	-	11	1283	c.1019C>T	c.(1018-1020)tCc>tTc	p.S340F	ATP9A_ENST00000311637.5_Missense_Mutation_p.S204F|ATP9A_ENST00000402822.1_Missense_Mutation_p.S219F	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	340					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GATGATGTTGGAAAACAAGAG	0.512000													15	60					0	0	1	0	0
ACAP3	116983	broad.mit.edu	37	1	1230858	1230858	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1230858G>A	ENST00000354700.5	-	19	1984	c.1782C>T	c.(1780-1782)ttC>ttT	p.F594F	ACAP3_ENST00000353662.3_Silent_p.F552F	NM_030649.2	NP_085152.2	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	594					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			endometrium(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	14						CCCCTGCGTCGAAGTAGGAGA	0.667000													4	54					0	0	1	0	0
CDC42EP3	10602	broad.mit.edu	37	2	37873403	37873403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37873403G>A	ENST00000295324.3	-	2	1328	c.328C>T	c.(328-330)Ccg>Tcg	p.P110S	AC006369.2_ENST00000419425.1_RNA	NM_001270436.1|NM_001270437.1|NM_001270438.1|NM_006449.3	NP_001257365.1|NP_001257366.1|NP_001257367.1|NP_006440.2	Q9UKI2	BORG2_HUMAN	CDC42 effector protein (Rho GTPase binding) 3	110					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding			endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	11		all_hematologic(82;0.172)				CCAATGGTCGGGAGGGAGATG	0.547000													18	151					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38357943	38357943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38357943C>T	ENST00000273173.4	+	9	1752	c.1661C>T	c.(1660-1662)tCc>tTc	p.S554F	SLC22A14_ENST00000448498.1_Missense_Mutation_p.S554F	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	554						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GTGGCCTTTTCCCTCTCCTCC	0.612000													17	37					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26446395	26446395	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26446395C>T	ENST00000265944.5	+	26	3116	c.2950C>T	c.(2950-2952)Cga>Tga	p.R984*	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	984	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.R984*(3)		NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGCAAGAATTCGAAGACTAGG	0.363000													39	101					0	0	1	0	0
CHST2	9435	broad.mit.edu	37	3	142840921	142840921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142840921G>A	ENST00000309575.3	+	2	2647	c.1263G>A	c.(1261-1263)ctG>ctA	p.L421L		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	421					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						GCCACTACCTGGTGGTGCGGT	0.587000													7	59					0	0	1	0	0
ELOVL7	79993	broad.mit.edu	37	5	60067763	60067763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:60067763G>A	ENST00000505959.1	-	6	709	c.183C>T	c.(181-183)ttC>ttT	p.F61F	ELOVL7_ENST00000425382.1_Silent_p.F74F|ELOVL7_ENST00000438340.1_Silent_p.F74F|ELOVL7_ENST00000508821.1_Silent_p.F74F			A1L3X0	ELOV7_HUMAN	ELOVL fatty acid elongase 7	74					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	9		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				AGAGTACTATGAAAAAATTGT	0.358000													14	30					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233323688	233323688	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233323688G>A	ENST00000295463.3	+	11	1496	c.1419G>A	c.(1417-1419)gaG>gaA	p.E473E		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	473					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GTGTGCAGGAGCAGAGCTTCG	0.711000													6	14					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140434525	140434525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:140434525G>A	ENST00000288602.6	-	18	2233	c.2173C>T	c.(2173-2175)Cac>Tac	p.H725Y		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	725					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GCACTGCGGTGAATTTTTGGC	0.393000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				57	143					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10916776	10916776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10916776C>T	ENST00000254488.2	+	6	953	c.887C>T	c.(886-888)cCc>cTc	p.P296L		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	296					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CTCTCCGACCCCCAGGTAAGA	0.592000													9	73					0	0	1	0	0
GRB2	2885	broad.mit.edu	37	17	73322082	73322082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73322082G>A	ENST00000392562.1	-	4	978	c.196C>T	c.(196-198)Ccc>Tcc	p.P66S	GRB2_ENST00000578961.1_Missense_Mutation_p.P66S|GRB2_ENST00000316615.5_Intron|GRB2_ENST00000462266.1_5'UTR|GRB2_ENST00000392563.1_Intron|GRB2_ENST00000392564.1_Missense_Mutation_p.P66S|GRB2_ENST00000316804.5_Missense_Mutation_p.P66S			P62993	GRB2_HUMAN	growth factor receptor-bound protein 2	66	SH2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	17	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	TTGGCTCTGGGGATTTTGCCA	0.507000													34	77					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594352	140594352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140594352C>T	ENST00000341948.4	+	1	844	c.657C>T	c.(655-657)ggC>ggT	p.G219G		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		219	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGATGGTGGCTCTCCGCCCA	0.532000													36	142					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663602	169663602	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169663602G>A	ENST00000483289.2	-	0	3692				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						AGAGGGGAAAGACCACTCTTC	0.423000													5	16					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207758215	207758215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207758215C>T	ENST00000367049.4	+	33	5524	c.5524C>T	c.(5524-5526)Cgt>Tgt	p.R1842C	CR1_ENST00000400960.2_Missense_Mutation_p.R1392C|CR1_ENST00000367052.1_Missense_Mutation_p.R1392C|CR1_ENST00000367053.1_Missense_Mutation_p.R1392C|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367051.1_Missense_Mutation_p.R1392C|RP11-78B10.2_ENST00000597497.1_RNA	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1392	Sushi 28.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ACTTTCTGTTCGTGCTGGTCA	0.488000													41	86					0	0	1	0	0
OR10W1	81341	broad.mit.edu	37	11	58035215	58035215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58035215G>A	ENST00000395079.2	-	1	517	c.116C>T	c.(115-117)tCc>tTc	p.S39F		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				TGTGTGAATGGACACCACAAT	0.488000													22	60					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130789705	130789705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:130789705C>T	ENST00000276708.4	-	2	1010	c.129G>A	c.(127-129)aaG>aaA	p.K43K		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	43						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						AACGAGAATCCTTCTTCTTTC	0.393000													40	85					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475396	120475396	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:120475396C>T	ENST00000355622.6	+	3	1091	c.990C>T	c.(988-990)ttC>ttT	p.F330F	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.F290F	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	330					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity	p.F330F(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CTTATAATTTCGGATGGCAAC	0.323000													20	77					0	0	1	0	0
OR1F1	4992	broad.mit.edu	37	16	3255061	3255061	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3255061C>T	ENST00000304646.2	+	1	815	c.815C>T	c.(814-816)aCt>aTt	p.T272I	AJ003147.9_ENST00000576468.1_RNA	NM_012360.1	NP_036492.1	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F, member 1	272					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(7)	11						GAGAAAGACACTATGGCTACT	0.468000													40	144					0	0	1	0	0
ODAM	54959	broad.mit.edu	37	4	71068536	71068536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71068536G>A	ENST00000396094.2	+	9	760	c.712G>A	c.(712-714)Gga>Aga	p.G238R		NM_017855.3	NP_060325.3	A1E959	ODAM_HUMAN	odontogenic, ameloblast asssociated	238					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(3)|skin(2)	20						TGACAGTGCAGGAGTTTTCAT	0.413000													24	78					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31498855	31498855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31498855C>T	ENST00000330498.3	+	7	679	c.660C>T	c.(658-660)ttC>ttT	p.F220F	AC026471.6_ENST00000565137.1_RNA	NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	220					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						CGGCAGCCTTCCACGAGGTGG	0.667000													28	87					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159409	18159409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18159409C>T	ENST00000396275.2	+	3	1021	c.660C>T	c.(658-660)ctC>ctT	p.L220L		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	220						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						CCATCCTCCTCACAGTGCTGG	0.552000													28	77					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207642028	207642028	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207642028G>A	ENST00000367057.3	+	3	791	c.602G>A	c.(601-603)gGa>gAa	p.G201E	CR2_ENST00000367058.3_Missense_Mutation_p.G201E|CR2_ENST00000485707.1_3'UTR|CR2_ENST00000458541.2_Missense_Mutation_p.G201E|CR2_ENST00000367059.3_Missense_Mutation_p.G201E	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	201	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TTGTCTTCGGGAAAATGGAGT	0.418000													55	160					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13185135	13185135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13185135C>T	ENST00000379345.2	+	5	575	c.334C>T	c.(334-336)Cct>Tct	p.P112S	PHACTR1_ENST00000457702.2_Intron|PHACTR1_ENST00000379350.1_Intron|PHACTR1_ENST00000332995.7_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	51						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TGCTGCTTTCCCTGGAGACCA	0.577000													29	99					0	0	1	0	0
WNT6	7475	broad.mit.edu	37	2	219738374	219738374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219738374C>T	ENST00000233948.3	+	4	1122	c.905C>T	c.(904-906)tCc>tTc	p.S302F		NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	302					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCACCGGCTCCCCCGGCACG	0.761000													9	18					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13829732	13829732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13829732G>A	ENST00000265104.4	-	38	6435	c.6331C>T	c.(6331-6333)Cgt>Tgt	p.R2111C		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2111	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATAATCTGACGGTCAGGCACC	0.463000									Kartagener syndrome				25	83					0	0	1	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1629548	1629548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1629548C>T	ENST00000399685.1	-	1	145	c.68G>A	c.(67-69)gGc>gAc	p.G23D		NM_001012708.2	NP_001012726.1	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	23						keratin filament				endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	8		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		GGAGCCACAGCCCCCACAGCT	0.662000													67	142					0	0	1	0	0
DDAH1	23576	broad.mit.edu	37	1	85817238	85817238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85817238G>A	ENST00000284031.8	-	3	522	c.428C>T	c.(427-429)tCc>tTc	p.S143F	DDAH1_ENST00000539042.1_Missense_Mutation_p.S143F|DDAH1_ENST00000535924.2_Missense_Mutation_p.S40F|DDAH1_ENST00000542148.1_Missense_Mutation_p.S43F|DDAH1_ENST00000426972.3_Missense_Mutation_p.S50F|RP11-131L23.1_ENST00000427819.1_RNA|DDAH1_ENST00000483110.1_5'UTR|RP11-131L23.1_ENST00000426125.1_RNA	NM_012137.3	NP_036269.1	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	143					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|skin(1)	5				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	TGTCCTTTTGGAAAGGCCCAC	0.363000													12	105					0	0	1	0	0
NUBP2	10101	broad.mit.edu	37	16	1838710	1838710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1838710C>T	ENST00000262302.9	+	7	931	c.811C>T	c.(811-813)Ccc>Tcc	p.P271S	NUBP2_ENST00000565987.1_Missense_Mutation_p.P211S|NUBP2_ENST00000568706.1_Missense_Mutation_p.P130S|NUBP2_ENST00000543305.1_Missense_Mutation_p.P130S	NM_012225.2	NP_036357.1	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2	271						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						CGCGTGCCTCCCCTGACTAAG	0.662000													5	23					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61844389	61844389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61844389C>T	ENST00000280772.1	-	32	4236	c.4045G>A	c.(4045-4047)Gag>Aag	p.E1349K	ANK3_ENST00000355288.2_Missense_Mutation_p.E483K|ANK3_ENST00000503366.1_Missense_Mutation_p.E1350K|ANK3_ENST00000373827.2_Missense_Mutation_p.E1343K	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1349					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCGACTTCCTCAAAATTCTCT	0.363000													46	128					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189065014	189065014	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189065014G>A	ENST00000332517.3	+	4	898	c.758_splice	c.e4+1	p.R253_splice	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	253					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GCCCTGGAAAGGTAGGCTTTC	0.493000													48	199					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327814	85327814	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85327814C>T	ENST00000299927.3	+	1	1930	c.1908C>T	c.(1906-1908)gcC>gcT	p.A636A	ZNF592_ENST00000560079.2_Silent_p.A636A			Q92610	ZN592_HUMAN	zinc finger protein 592	636					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCCGGCACGCCCGTGACCACA	0.597000													20	84					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3655168	3655168	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3655168C>T	ENST00000263087.4	-	15	1767	c.1668_splice	c.e15-1	p.D557_splice		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	557					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		AAAGAACCATCCTGTAAAGCA	0.597000													25	29					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78547309	78547309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78547309G>A	ENST00000545128.1	+	2	745	c.207G>A	c.(205-207)aaG>aaA	p.K69K	PCSK5_ENST00000376752.4_Silent_p.K69K|PCSK5_ENST00000376767.3_Silent_p.K69K	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	69					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GGGCCCTGAAGGACTACTACC	0.408000													22	46					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96698454	96698454	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96698454G>A	ENST00000260682.6	+	1	27	c.15G>A	c.(13-15)gtG>gtA	p.V5V	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	5					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	ATTCTCTTGTGGTCCTTGTGC	0.493000													94	239					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233137405	233137405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233137405G>A	ENST00000258229.8	-	29	5209	c.4975C>T	c.(4975-4977)Ctc>Ttc	p.L1659F	PCNXL2_ENST00000344698.2_Missense_Mutation_p.L311F	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1659						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGGACATGGAGGCCATACAGG	0.433000													5	11					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1395328	1395328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1395328G>A	ENST00000324385.5	+	22	2282	c.2124G>A	c.(2122-2124)agG>agA	p.R708R	BAIAP3_ENST00000426824.3_Silent_p.R673R|BAIAP3_ENST00000397488.2_Silent_p.R690R|BAIAP3_ENST00000421665.2_Silent_p.R637R|BAIAP3_ENST00000397489.1_Silent_p.R690R|BAIAP3_ENST00000562208.1_Silent_p.R650R|BAIAP3_ENST00000568887.1_Silent_p.R645R	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	708	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				AAGTGCTGAGGGACCAGGCCA	0.672000													21	32					0	0	1	0	0
EVL	51466	broad.mit.edu	37	14	100551165	100551165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100551165C>T	ENST00000544450.2	+	2	448	c.165C>T	c.(163-165)gtC>gtT	p.V55V	EVL_ENST00000402714.2_Silent_p.V49V|EVL_ENST00000392920.3_Silent_p.V51V|EVL_ENST00000555048.1_3'UTR			Q9UI08	EVL_HUMAN	Enah/Vasp-like	49	WH1.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				CCTTCAGAGTCGTTGGAGTCA	0.527000													10	87					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2884530	2884530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:2884530C>T	ENST00000254695.8	+	10	807	c.717C>T	c.(715-717)gtC>gtT	p.V239V	RAP1GAP2_ENST00000366401.4_Silent_p.V224V|RAP1GAP2_ENST00000540393.2_Silent_p.V220V|RAP1GAP2_ENST00000542807.1_Silent_p.V239V	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	239					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						TCAATCCTGTCCTGTACCCCA	0.527000													8	10					0	0	1	0	0
EPT1	85465	broad.mit.edu	37	2	26607905	26607905	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26607905C>T	ENST00000260585.7	+	8	929	c.810C>T	c.(808-810)ttC>ttT	p.F270F		NM_033505.2	NP_277040.1	Q9C0D9	EPT1_HUMAN	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	270					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding										GCTTGCTGTTCATTTTGTCTA	0.358000													14	48					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156631840	156631840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156631840C>T	ENST00000296518.7	+	6	732	c.523C>T	c.(523-525)Cat>Tat	p.H175Y	GUCY1A3_ENST00000393832.3_5'UTR|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.H175Y|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.H175Y|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.H175Y|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.H175Y|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.H175Y			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	175				VIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLK QSSHCQEAGKRGR -> LSKNLLVKRFLKYVTRKMKTSLGW LEAPLKIFKQLQYPSETEQPLPRSRKKGQ (in Ref. 1).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ACAGAGCAGCCATTGCCAAGA	0.433000													29	57					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50213657	50213657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50213657C>T	ENST00000392518.4	+	15	2019	c.1647C>T	c.(1645-1647)tcC>tcT	p.S549S	CPT1C_ENST00000405931.2_Silent_p.S538S|CPT1C_ENST00000323446.5_Silent_p.S549S|CPT1C_ENST00000354199.5_Silent_p.S549S|CPT1C_ENST00000598293.1_Silent_p.S549S	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	549					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTCCATTCTCCCTATTTGGCA	0.557000													17	87					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234458964	234458964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:234458964G>A	ENST00000366618.3	+	8	1593	c.1448G>A	c.(1447-1449)aGa>aAa	p.R483K	SLC35F3_ENST00000366617.3_Missense_Mutation_p.R414K	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	414					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			AAGAACAGAAGAGCCCGCCCT	0.577000											OREG0014330	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	46					0	0	1	0	0
ADRA1B	147	broad.mit.edu	37	5	159344514	159344514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:159344514C>T	ENST00000306675.3	+	1	725	c.602C>T	c.(601-603)cCc>cTc	p.P201L		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	201					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	ACCGAAGAACCCTTCTATGCC	0.567000													46	109					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597445	136597445	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136597445C>T	ENST00000531224.1	-	5	1470	c.1218G>A	c.(1216-1218)gaG>gaA	p.E406E	BCLAF1_ENST00000527536.1_Silent_p.E406E|BCLAF1_ENST00000527759.1_Silent_p.E404E|BCLAF1_ENST00000392348.2_Silent_p.E404E|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000353331.4_Silent_p.E404E	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	406					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GTCTATAATCCTCTGTCTCCT	0.428000													32	522					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95610021	95610021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95610021G>A	ENST00000395505.2	-	3	1032	c.940C>T	c.(940-942)Cat>Tat	p.H314Y	ZNF484_ENST00000332591.6_Missense_Mutation_p.H314Y|ZNF484_ENST00000375495.3_Missense_Mutation_p.H350Y|ZNF484_ENST00000395506.3_Missense_Mutation_p.H352Y|ANKRD19P_ENST00000473204.1_RNA	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						TCTCCAGAATGAATTCTCTGG	0.368000													15	42					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368424	86368424	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:86368424C>T	ENST00000400286.2	-	2	2818	c.2220G>A	c.(2218-2220)acG>acA	p.T740T		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	740						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TTGATTGGTTCGTGGTTTTGT	0.368000													85	302					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196709789	196709789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196709789C>T	ENST00000312428.6	-	47	8982	c.8882G>A	c.(8881-8883)cGa>cAa	p.R2961Q		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2961	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATTCCAAGTTCGAATTGTCAC	0.363000													8	43					0	0	1	0	0
VOPP1	81552	broad.mit.edu	37	7	55560108	55560108	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55560108G>A	ENST00000285279.5	-	4	395	c.195C>T	c.(193-195)ttC>ttT	p.F65F	VOPP1_ENST00000454227.1_Silent_p.F2F|VOPP1_ENST00000428097.1_5'UTR|VOPP1_ENST00000453256.1_5'UTR|VOPP1_ENST00000418904.1_Silent_p.F48F|VOPP1_ENST00000428648.1_5'UTR|VOPP1_ENST00000433959.1_Silent_p.F56F|VOPP1_ENST00000427700.1_Silent_p.F63F|VOPP1_ENST00000545390.1_Silent_p.F62F	NM_030796.3	NP_110423.3	Q96AW1	VOPP1_HUMAN	vesicular, overexpressed in cancer, prosurvival protein 1	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity			endometrium(1)|lung(4)	5						TCATCAGAAGGAACCTGAGGA	0.632000													5	19					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502112	90502112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90502112G>A	ENST00000325643.5	+	4	2776	c.2710G>A	c.(2710-2712)Gga>Aga	p.G904R		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GAATGGTCCAGGAGACAACAG	0.597000													10	60					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18725192	18725192	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18725192G>A	ENST00000440756.2	-	4	1728	c.1626C>T	c.(1624-1626)ttC>ttT	p.F542F	PSD3_ENST00000327040.8_Silent_p.F542F|PSD3_ENST00000523619.1_Silent_p.F477F			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	542	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACCTTCCCCAGAAAGCAATCT	0.458000													6	67					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103568562	103568562	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103568562T>C	ENST00000380069.3	+	2	578	c.502T>C	c.(502-504)Ttt>Ctt	p.F168L		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	168										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CTCGCGCACCTTTGAGCAGGA	0.662000													5	7					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67124879	67124879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67124879G>A	ENST00000284425.2	-	8	1174	c.1000C>T	c.(1000-1002)Ctc>Ttc	p.L334F		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	334					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AGGGTAAGGAGAAACACAACC	0.408000													25	117					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	167020477	167020477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:167020477C>T	ENST00000061240.2	+	20	3352	c.2705C>T	c.(2704-2706)tCa>tTa	p.S902L	TLL1_ENST00000507499.1_Missense_Mutation_p.S925L	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	902	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GATCTGTACTCACATGCTCAG	0.443000													70	145					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58342391	58342391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58342391C>T	ENST00000371015.1	+	5	1159	c.692C>T	c.(691-693)cCc>cTc	p.P231L	PHACTR3_ENST00000395639.4_Intron|PHACTR3_ENST00000361300.4_Intron|PHACTR3_ENST00000359926.3_Missense_Mutation_p.P228L|PHACTR3_ENST00000541461.1_Missense_Mutation_p.P190L|PHACTR3_ENST00000395636.2_Missense_Mutation_p.P190L|PHACTR3_ENST00000355648.4_Missense_Mutation_p.P190L	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	231	Pro-rich.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CTCCCCAGCCCCCCACTGCTG	0.592000													18	38					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173915704	173915704	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173915704G>A	ENST00000367696.2	-	17	3222	c.2871C>T	c.(2869-2871)ccC>ccT	p.P957P	RC3H1_ENST00000367694.2_Silent_p.P957P|RC3H1_ENST00000258349.4_Silent_p.P957P			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	957					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						CAGATGGAAGGGGTTTTCCAT	0.413000													20	94					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59283076	59283076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59283076G>A	ENST00000329328.3	+	1	691	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						TCACACTGGGGAAGGCAGGAG	0.502000													26	262					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39316095	39316095	+	Missense_Mutation	SNP	C	C	T	rs148389506		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39316095C>T	ENST00000263408.4	-	6	747	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	218	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ATTTGTTCTTCGTAATGTTCG	0.303000													15	43					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101190431	101190431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:101190431G>A	ENST00000294728.2	+	4	1014	c.913G>A	c.(913-915)Gaa>Aaa	p.E305K	VCAM1_ENST00000347652.2_Missense_Mutation_p.E305K|VCAM1_ENST00000370115.1_Missense_Mutation_p.E305K|VCAM1_ENST00000370119.4_Missense_Mutation_p.E243K	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	305	Ig-like C2-type 3.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AAAAGAGGTGGAATTAATTGT	0.373000													10	62					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8890460	8890460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:8890460G>A	ENST00000256707.3	-	24	3377	c.3196C>T	c.(3196-3198)Cgt>Tgt	p.R1066C	KIDINS220_ENST00000427284.1_Missense_Mutation_p.R1066C|KIDINS220_ENST00000418530.1_Missense_Mutation_p.R1024C|KIDINS220_ENST00000473731.1_Missense_Mutation_p.R1066C	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1066					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTGGCAGCACGAACATCTGAA	0.512000													9	25					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064729	78064729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:78064729C>T	ENST00000299642.4	+	3	697	c.612C>T	c.(610-612)atC>atT	p.I204I	CLEC3A_ENST00000575655.1_Silent_p.I195I|CLEC3A_ENST00000565808.1_3'UTR|RP11-281J9.2_ENST00000563114.1_RNA	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	195					skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						AGTTCACCATCCCTCAATAGG	0.423000													5	42					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834355	101834355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101834355C>T	ENST00000506729.1	-	1	365	c.194G>A	c.(193-195)cGa>cAa	p.R65Q	SLCO6A1_ENST00000379807.3_Missense_Mutation_p.R65Q|SLCO6A1_ENST00000379810.1_Missense_Mutation_p.R65Q|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.R65Q|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.R65Q			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	65						integral to membrane|plasma membrane	transporter activity	p.R65Q(2)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TTTCCTTTTTCGGAAACCGCC	0.542000													80	215					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64152334	64152334	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:64152334C>T	ENST00000395391.1	+	3	1390	c.15C>T	c.(13-15)ccC>ccT	p.P5P	ZNF107_ENST00000344930.3_Silent_p.P5P|ZNF107_ENST00000423627.1_Silent_p.P5P			Q9UII5	ZN107_HUMAN	zinc finger protein 107	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TAGCCAAACCCCCAGGTAGGT	0.398000													23	144					0	0	1	0	0
DCD	117159	broad.mit.edu	37	12	55039011	55039011	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55039011C>T	ENST00000456047.2	-	4	424	c.235G>A	c.(235-237)Gga>Aga	p.G79R	DCD_ENST00000293371.6_Missense_Mutation_p.G79R			P81605	DCD_HUMAN	dermcidin	79					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			large_intestine(2)|lung(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(1001;0.0255)				TTTCCGAGTCCCCCCACAGCT	0.478000													33	87					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73636011	73636011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73636011G>A	ENST00000261917.3	-	2	1917	c.924C>T	c.(922-924)atC>atT	p.I308I		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	308					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GGACCAAGTCGATGAGGAAGA	0.488000													10	58					0	0	1	0	0
P2RX5	5026	broad.mit.edu	37	17	3595104	3595104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3595104C>T	ENST00000552050.1	-	1	192	c.14G>A	c.(13-15)cGg>cAg	p.R5Q	P2RX5_ENST00000225328.5_Intron|RP11-48B14.2_ENST00000550383.1_Intron|P2RX5_ENST00000547178.1_Intron|P2RX5_ENST00000551178.1_Intron|P2RX5_ENST00000552276.1_Intron|P2RX5_ENST00000435558.1_Intron|P2RX5_ENST00000345901.3_Intron			Q93086	P2RX5_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 5	0					nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						GGAAGGGGGCCGGTACGTGGG	0.602000													14	83					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114290925	114290925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:114290925C>T	ENST00000297405.5	-	3	654	c.410G>A	c.(409-411)gGa>gAa	p.G137E	CSMD3_ENST00000455883.2_Missense_Mutation_p.G137E|CSMD3_ENST00000343508.3_Missense_Mutation_p.G97E|CSMD3_ENST00000352409.3_Missense_Mutation_p.G137E	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	137	CUB 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAGATGGAATCCTGTTAACCT	0.308000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	67					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091388	9091388	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9091388C>T	ENST00000397910.4	-	1	630	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	143	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.E143K(2)|p.E143Q(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTAGATGCTTCTTTGGTAAAA	0.488000													31	55					0	0	1	0	0
NANOS3	342977	broad.mit.edu	37	19	13988354	13988354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13988354G>A	ENST00000397555.2	+	2	235	c.235G>A	c.(235-237)Gag>Aag	p.E79K	NANOS3_ENST00000591727.1_Intron|NANOS3_ENST00000591161.1_Intron|NANOS3_ENST00000339133.5_Missense_Mutation_p.E98K	NM_001098622.2	NP_001092092.1	P60323	NANO3_HUMAN	nanos homolog 3 (Drosophila)	79					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding	p.E98K(1)		breast(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	7			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GCTGAAGGACGAGGCTGGCAG	0.662000													10	36					0	0	1	0	0
SHISA3	152573	broad.mit.edu	37	4	42403225	42403225	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42403225C>T	ENST00000319234.4	+	2	692	c.474C>T	c.(472-474)ccC>ccT	p.P158P		NM_001080505.1	NP_001073974.1	A0PJX4	SHSA3_HUMAN	shisa family member 3	158					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	12						CCAGGGCACCCTCCCGGCAGT	0.667000													64	162					0	0	1	0	0
ZNF619	285267	broad.mit.edu	37	3	40529675	40529675	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:40529675C>T	ENST00000447116.2	+	6	2101	c.1794C>T	c.(1792-1794)ctC>ctT	p.L598L	ZNF619_ENST00000432264.2_Silent_p.L558L|ZNF619_ENST00000521353.1_Silent_p.L598L|ZNF619_ENST00000456778.1_Silent_p.L514L|ZNF619_ENST00000429348.2_Silent_p.L558L|ZNF619_ENST00000314686.5_Silent_p.L542L|ZNF619_ENST00000520737.1_3'UTR|ZNF619_ENST00000522736.1_Silent_p.L549L	NM_001145082.2	NP_001138554.1	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619	598					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TTCAGGATCTCGCTTTTCCTG	0.498000													98	78					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29012409	29012409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29012409G>A	ENST00000282397.4	-	4	713	c.462C>T	c.(460-462)ctC>ctT	p.L154L	FLT1_ENST00000541932.1_Silent_p.L154L|FLT1_ENST00000539099.1_Silent_p.L154L	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	154	Ig-like C2-type 2.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGGGAATGACGAGCTCCCTTC	0.388000													41	20					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628876	71628876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71628876C>T	ENST00000377276.2	-	1	163	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	45	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CTGAGCCGTTCGAACTGATCC	0.602000													13	55					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325311	150325311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150325311G>A	ENST00000493969.1	-	3	328	c.151C>T	c.(151-153)Cgt>Tgt	p.R51C	GIMAP6_ENST00000328902.5_Silent_p.A125A	NM_001244071.1	NP_001231000.1	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	0							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCAGGAGCACGGCGTGGGGCC	0.622000													32	68					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7651534	7651534	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7651534C>T	ENST00000359156.4	-	4	910	c.708G>A	c.(706-708)tgG>tgA	p.W236*	CD163_ENST00000541972.1_Nonsense_Mutation_p.W224*|CD163_ENST00000396620.3_Nonsense_Mutation_p.W236*|CD163_ENST00000432237.2_Nonsense_Mutation_p.W236*	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	236	SRCR 2.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GTTTGCAGTTCCAGAGAGCTG	0.433000													55	172					0	0	1	0	0
GPR171	29909	broad.mit.edu	37	3	150916563	150916563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:150916563C>T	ENST00000309180.5	-	3	841	c.611G>A	c.(610-612)cGa>cAa	p.R204Q	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_013308.3	NP_037440.3	O14626	GP171_HUMAN	G protein-coupled receptor 171	204						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(4)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	15			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTAGAGCTGTCGAATTACAAG	0.328000													19	45					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3645678	3645678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3645678G>A	ENST00000294008.3	-	9	2581	c.1941C>T	c.(1939-1941)ccC>ccT	p.P647P		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	647	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						GAAGGCCGCCGGGCACCACGT	0.622000								Direct reversal of damage					14	38					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43547729	43547729	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43547729G>A	ENST00000395891.1	+	23	4470	c.3866_splice	c.e23+1	p.G1289_splice	HECW1_ENST00000453890.1_Splice_Site_p.G1255_splice	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1289	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TGGAGAGGAGGGGTGAGGCAC	0.532000													6	46					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241659339	241659339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241659339G>A	ENST00000498729.2	-	46	5119	c.4873C>T	c.(4873-4875)Ccg>Tcg	p.P1625S	KIF1A_ENST00000320389.7_Missense_Mutation_p.P1524S	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1524	PH.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CAGGGCTGCGGGGTCCTGGGA	0.682000													7	24					0	0	1	0	0
HEXA	3073	broad.mit.edu	37	15	72638914	72638914	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72638914G>A	ENST00000268097.5	-	11	1787	c.1284C>T	c.(1282-1284)ggC>ggT	p.G428G	RP11-106M3.3_ENST00000570175.1_RNA|HEXA_ENST00000567159.1_Silent_p.G428G|RP11-106M3.2_ENST00000379915.4_RNA|HEXA_ENST00000457859.2_Intron|HEXA_ENST00000566304.1_Silent_p.G439G|HEXA_ENST00000429918.2_Silent_p.G255G	NM_000520.4	NP_000511.2	P06865	HEXA_HUMAN	hexosaminidase A (alpha polypeptide)	428					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(3)|kidney(3)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	24						TCCAGTCAGGGCCATAGGATA	0.537000													113	204					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15990683	15990683	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15990683G>A	ENST00000221700.5	-	10	1235	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F	CYP4F2_ENST00000592328.1_Silent_p.F380F	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	380					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACATGGTCAGGAAGGGCAAAT	0.577000													59	129					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	53989385	53989385	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:53989385G>A	ENST00000514921.1	+	3	447	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	MLIP_ENST00000370877.2_Missense_Mutation_p.E60K|MLIP_ENST00000370876.2_Missense_Mutation_p.E50K|MLIP_ENST00000358276.5_Missense_Mutation_p.E106K|MLIP_ENST00000509997.1_Missense_Mutation_p.E60K|MLIP_ENST00000274897.5_Missense_Mutation_p.E112K|MLIP_ENST00000502396.1_Missense_Mutation_p.E123K|MLIP_ENST00000511744.1_3'UTR			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	112						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						AAGGGAATTCGAAGCAAACAA	0.453000													34	95					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171055856	171055856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171055856G>A	ENST00000334231.6	+	2	168	c.168G>A	c.(166-168)aaG>aaA	p.K56K	MYO3B_ENST00000409044.3_Silent_p.K47K|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000408978.4_Silent_p.K47K			Q8WXR4	MYO3B_HUMAN	myosin IIIB	47	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						TAACTAACAAGAGAGATGGGA	0.418000													9	48					0	0	1	0	0
TRAK2	66008	broad.mit.edu	37	2	202245709	202245709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202245709G>A	ENST00000332624.3	-	16	2730	c.2302C>T	c.(2302-2304)Cct>Tct	p.P768S		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	768				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						AGGGATTTAGGGAGAGGCTGG	0.512000													16	169					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002110	98002110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98002110C>T	ENST00000355273.2	+	1	379	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						GGCATATGATCGCTATGTAGC	0.378000													9	125					0	0	1	0	0
EPS8L2	64787	broad.mit.edu	37	11	724744	724744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:724744C>T	ENST00000533256.1	+	17	1850	c.1475C>T	c.(1474-1476)gCc>gTc	p.A492V	EPS8L2_ENST00000526198.1_Missense_Mutation_p.A508V|EPS8L2_ENST00000318562.8_Missense_Mutation_p.A492V|EPS8L2_ENST00000530636.1_Missense_Mutation_p.A492V|AP006621.9_ENST00000527021.2_RNA			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	492	SH3.					cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCAACACCAGCCATGGCCAAG	0.617000													20	41					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60899610	60899610	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60899610C>T	ENST00000252999.3	-	42	5596	c.5529_splice	c.e42-1	p.E1844_splice		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1844	Laminin EGF-like 16; second part.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGCACATTCCTGAGGGTGT	0.627000													9	11					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114276620	114276620	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114276620C>T	ENST00000357077.4	+	38	6899	c.6846C>T	c.(6844-6846)acC>acT	p.T2282T	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.T2249T|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2249					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCCCACGACCAAAGACATTA	0.483000													12	39					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48650406	48650406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48650406G>A	ENST00000352832.5	+	7	1444	c.1072G>A	c.(1072-1074)Gac>Aac	p.D358N	CACNA1G_ENST00000514717.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000515765.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000510366.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000512389.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000513964.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000513689.2_Missense_Mutation_p.D358N|CACNA1G_ENST00000507609.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000505165.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000507336.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000507510.2_Missense_Mutation_p.D358N|CACNA1G_ENST00000442258.2_Missense_Mutation_p.D358N|CACNA1G_ENST00000514181.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000429973.2_Missense_Mutation_p.D358N|CACNA1G_ENST00000514079.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000515165.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000510115.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000503485.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000358244.5_Missense_Mutation_p.D358N|CACNA1G_ENST00000502264.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000416767.4_Missense_Mutation_p.D358N|CACNA1G_ENST00000359106.5_Missense_Mutation_p.D358N|CACNA1G_ENST00000354983.4_Missense_Mutation_p.D358N|CACNA1G_ENST00000507896.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000515411.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000360761.4_Missense_Mutation_p.D358N	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	358					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGGCTGGGTCGACATCATGTA	0.552000													4	8					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102611376	102611376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:102611376G>A	ENST00000251808.3	+	8	1433	c.1095G>A	c.(1093-1095)gcG>gcA	p.A365A	GRHL2_ENST00000395927.1_Silent_p.A349A	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	365						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATGAAGAGGCGAAGGTGAGTG	0.378000													15	26					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3200901	3200901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3200901G>A	ENST00000520002.1	-	24	4104	c.3549C>T	c.(3547-3549)atC>atT	p.I1183I	CSMD1_ENST00000542608.1_Silent_p.I1182I|CSMD1_ENST00000400186.3_Silent_p.I1183I|CSMD1_ENST00000602557.1_Silent_p.I1183I|CSMD1_ENST00000537824.1_Silent_p.I1182I|CSMD1_ENST00000602723.1_Silent_p.I1183I|CSMD1_ENST00000539096.1_Silent_p.I1182I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1183	CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCTGTTTAGGATCAGCCCCA	0.448000													19	63					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40900930	40900930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40900930C>T	ENST00000324001.7	-	7	3599	c.3329G>A	c.(3328-3330)gGg>gAg	p.G1110E	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1110	Glu-rich (acidic).				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTCTGCCCTCCCTTCCTCCTG	0.667000													22	62					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24689299	24689299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:24689299G>A	ENST00000396475.2	+	5	638	c.339G>A	c.(337-339)atG>atA	p.M113I	MPP6_ENST00000222644.4_Missense_Mutation_p.M113I|MPP6_ENST00000409761.1_Start_Codon_SNP_p.M1I	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	113					protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						GCCCAGAAATGAATAATTCTT	0.383000													24	84					0	0	1	0	0
ZNF467	168544	broad.mit.edu	37	7	149468110	149468110	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149468110G>A	ENST00000302017.3	-	2	425	c.12C>T	c.(10-12)acC>acT	p.T4T	ZNF467_ENST00000484747.1_Silent_p.T4T	NM_207336.1	NP_997219.1	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|urinary_tract(1)	13	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGGCCTCCAAGGTCTCTCTCA	0.542000													31	91					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21051370	21051370	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21051370G>A	ENST00000381545.3	+	14	1902	c.1682_splice	c.e14-1	p.K561_splice	SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000540229.1_Splice_Site_p.K561_splice|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Splice_Site_p.K561_splice|SLCO1B3_ENST00000553473.1_Splice_Site_p.K561_splice	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	561					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					CATATTTCAGGATTGTTCAAC	0.299000													16	71					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71795107	71795107	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71795107C>T	ENST00000258104.3	+	25	2815	c.2538C>T	c.(2536-2538)gcC>gcT	p.A846A	DYSF_ENST00000410041.1_Silent_p.A864A|DYSF_ENST00000429174.2_Silent_p.A846A|DYSF_ENST00000409744.1_Silent_p.A833A|DYSF_ENST00000410020.3_Silent_p.A864A|DYSF_ENST00000394120.2_Silent_p.A847A|DYSF_ENST00000409366.1_Silent_p.A847A|DYSF_ENST00000409582.3_Silent_p.A863A|DYSF_ENST00000413539.2_Silent_p.A877A|DYSF_ENST00000409651.1_Silent_p.A878A|DYSF_ENST00000409762.1_Silent_p.A863A	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	846						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TGCCTGGCGCCCGGATGCCAG	0.572000													35	65					0	0	1	0	0
HLA-V	352962	broad.mit.edu	37	6	29761626	29761626	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29761626C>T	ENST00000457107.1	+	0	852																											tccccttgtcctgttgtaagt	0.502000													8	19					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197890486	197890486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197890486G>A	ENST00000367390.3	+	4	430	c.403G>A	c.(403-405)Gag>Aag	p.E135K	LHX9_ENST00000367391.1_Missense_Mutation_p.E135K|LHX9_ENST00000367387.4_Missense_Mutation_p.E144K|LHX9_ENST00000337020.2_Missense_Mutation_p.E144K|LHX9_ENST00000561173.1_Missense_Mutation_p.E150K	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	144	LIM zinc-binding 2.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding	p.E144*(1)|p.E135*(1)		endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						TTCCGCCTCGGAGATGGTCAT	0.572000													23	65					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24924372	24924372	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24924372C>T	ENST00000329468.2	+	1	3832	c.3358C>T	c.(3358-3360)Caa>Taa	p.Q1120*		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TCCTGCTTTTCAACAGTGCAT	0.468000													75	115					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42331169	42331169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42331169C>T	ENST00000217026.4	+	8	1118	c.991C>T	c.(991-993)Cct>Tct	p.P331S	MYBL2_ENST00000396863.4_Missense_Mutation_p.P307S	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	331						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ATTTGACCTCCCTGAGGAACC	0.522000													20	215					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47405400	47405400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47405400C>T	ENST00000285039.7	-	24	3490	c.3191G>A	c.(3190-3192)cGa>cAa	p.R1064Q	MYO5B_ENST00000324581.6_Missense_Mutation_p.R205Q	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1064					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GTACCGGGATCGCTCCTCCTC	0.468000													23	60					0	0	1	0	0
ABCG1	9619	broad.mit.edu	37	21	43708058	43708058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43708058C>T	ENST00000398437.1	+	10	1619	c.1471C>T	c.(1471-1473)Cgg>Tgg	p.R491W	ABCG1_ENST00000340588.4_Missense_Mutation_p.R453W|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000398449.3_Missense_Mutation_p.R345W|ABCG1_ENST00000343687.3_Missense_Mutation_p.R356W|ABCG1_ENST00000398457.2_Missense_Mutation_p.R347W|ABCG1_ENST00000361802.2_Missense_Mutation_p.R345W|ABCG1_ENST00000347800.2_Missense_Mutation_p.R342W			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	345	ABC transmembrane type-2.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	GAGAGCGGTTCGGGAGGGCAT	0.602000													46	218					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43610524	43610524	+	Silent	SNP	C	C	T	rs138052948		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43610524C>T	ENST00000372806.3	+	4	395	c.300C>T	c.(298-300)atC>atT	p.I100I	STK4_ENST00000499879.2_Silent_p.I100I|STK4_ENST00000372801.1_Silent_p.I100I|STK4_ENST00000396731.4_Silent_p.I100I	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	100	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding	p.I100I(1)		NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				ACTTATGGATCGTTATGGAGT	0.363000													32	54					0	0	1	0	0
GARS	2617	broad.mit.edu	37	7	30671904	30671904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30671904G>A	ENST00000389266.3	+	16	2186	c.1945G>A	c.(1945-1947)Gat>Aat	p.D649N		NM_002047.2	NP_002038.2	P41250	SYG_HUMAN	glycyl-tRNA synthetase	649					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	24					Glycine(DB00145)	CAAAGTAGACGATTCCTCTGG	0.448000													26	72					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56646657	56646657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56646657G>A	ENST00000267116.7	-	12	1329	c.1208C>T	c.(1207-1209)tCa>tTa	p.S403L		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	403							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						ATTGCTGAGTGAAGACACAAT	0.512000													7	14					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96745809	96745809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96745809C>T	ENST00000260682.6	+	8	1181	c.1169C>T	c.(1168-1170)tCc>tTc	p.S390F		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	390					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	ATATTAATTTCCCTGACTTCT	0.378000													47	134					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995902	140995902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140995902C>T	ENST00000285879.4	+	4	2998	c.2712C>T	c.(2710-2712)ttC>ttT	p.F904F	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	904							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AGCCCTTGTTCACTTATACAC	0.478000										HNSCC(15;0.026)			84	77					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71411594	71411594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71411594G>A	ENST00000302628.4	+	4	363	c.286G>A	c.(286-288)Gag>Aag	p.E96K	CALB2_ENST00000349553.5_Missense_Mutation_p.E96K	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	96	EF-hand 2.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				GCCAACCGAAGAGAACTTCCT	0.552000													21	71					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101546431	101546431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101546431G>A	ENST00000353234.4	-	4	963	c.916C>T	c.(916-918)Cag>Tag	p.Q306*	ANKS6_ENST00000375018.1_Nonsense_Mutation_p.Q306*|ANKS6_ENST00000375019.2_Nonsense_Mutation_p.Q5*|ANKS6_ENST00000540940.1_Nonsense_Mutation_p.Q111*			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	306										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				TTGACCAGCTGGAAGTTTCCT	0.557000													13	29					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7769021	7769021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7769021G>A	ENST00000358415.4	+	10	1259	c.1093G>A	c.(1093-1095)Gct>Act	p.A365T	ITIH2_ENST00000379587.4_Missense_Mutation_p.A354T	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	365	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TTTAATTTCAGCTACAAAAAC	0.423000													21	65					0	0	1	0	0
SLAMF7	57823	broad.mit.edu	37	1	160719701	160719701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160719701G>A	ENST00000368043.3	+	3	504	c.467G>A	c.(466-468)gGg>gAg	p.G156E	SLAMF7_ENST00000441662.2_Intron|SLAMF7_ENST00000458602.2_Missense_Mutation_p.G49E|SLAMF7_ENST00000458104.2_Missense_Mutation_p.G49E|SLAMF7_ENST00000444090.2_Intron|SLAMF7_ENST00000368042.3_Missense_Mutation_p.G49E|SLAMF7_ENST00000359331.4_Missense_Mutation_p.G156E	NM_021181.3	NP_067004.3	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	156	Ig-like C2-type.				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATGGAACATGGGGAAGAGGAT	0.522000													41	108					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29142344	29142344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29142344G>A	ENST00000377167.2	+	1	1034	c.932G>A	c.(931-933)gGg>gAg	p.G311E		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TGGGAGTGGGGGAAGTGACAG	0.423000													24	45					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47286726	47286726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:47286726C>T	ENST00000311191.6	+	15	1877	c.1648C>T	c.(1648-1650)Cga>Tga	p.R550*	LRCH1_ENST00000389797.3_Nonsense_Mutation_p.R550*|LRCH1_ENST00000389798.3_Nonsense_Mutation_p.R550*	NM_001164213.1	NP_001157685.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	550										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CCTGAAGCCTCGATCAGGTAA	0.423000													63	130					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48451735	48451735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48451735G>A	ENST00000358536.4	-	31	5844	c.5575C>T	c.(5575-5577)Cgg>Tgg	p.R1859W	PLXNB1_ENST00000296440.6_Missense_Mutation_p.R1859W|PLXNB1_ENST00000358459.4_Missense_Mutation_p.R1676W|PLXNB1_ENST00000456774.1_Missense_Mutation_p.R1676W|PLXNB1_ENST00000448774.2_Missense_Mutation_p.R470W	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1859					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGGTTTTCCCGGAGCACATGC	0.627000													9	38					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9119182	9119182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:9119182C>T	ENST00000382496.5	-	15	2518	c.1853G>A	c.(1852-1854)cGg>cAg	p.R618Q		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	618	TSP type-1 2.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GGAGCGCTGCCGCACCTGGAA	0.652000													8	25					0	0	1	0	0
SCARB1	949	broad.mit.edu	37	12	125270724	125270724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125270724G>A	ENST00000415380.2	-	11	1705	c.1580C>T	c.(1579-1581)tCt>tTt	p.S527F	SCARB1_ENST00000339570.5_Intron|SCARB1_ENST00000540495.1_Missense_Mutation_p.S490F|SCARB1_ENST00000546215.1_Intron|SCARB1_ENST00000261693.6_Intron|SCARB1_ENST00000376788.1_Intron|SCARB1_ENST00000541205.1_Missense_Mutation_p.S486F|SCARB1_ENST00000535005.1_Intron|SCARB1_ENST00000544327.1_Missense_Mutation_p.S473F			Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1	527					adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	GCATGCAAAAGACGCAAGCGT	0.642000													8	9					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19753537	19753537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:19753537C>T	ENST00000400113.3	-	2	274	c.170G>A	c.(169-171)gGa>gAa	p.G57E		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	57					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CTTGCCAGCTCCAGTCTCACT	0.562000													29	108					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46962038	46962038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46962038C>T	ENST00000374323.3	-	7	1944	c.1357G>A	c.(1357-1359)Gag>Aag	p.E453K	RP11-38L15.3_ENST00000506914.1_RNA|SYT15_ENST00000374325.3_Intron|SYT15_ENST00000374321.4_Missense_Mutation_p.E400K|SYT15_ENST00000503753.1_Intron			Q9BQS2	SYT15_HUMAN	synaptotagmin XV	400						integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						CTGAGCATCTCGTCCCAGTGC	0.677000													20	79					0	0	1	0	0
MIR7162	102466227	broad.mit.edu	37	15	62539576	62539576	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:62539576C>T	ENST00000570077.1	-	0	206																											GCATACTGCTCTCTCTCCATT	0.567000													14	19					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925084	54925084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54925084G>A	ENST00000293373.6	+	23	2626	c.2547G>A	c.(2545-2547)atG>atA	p.M849I	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.M799I	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	849					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CCTATGGCATGAAGTTCCTGA	0.507000													18	221					0	0	1	0	0
SRCRB4D	136853	broad.mit.edu	37	7	76027102	76027102	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76027102G>A	ENST00000275560.3	-	6	948	c.601C>T	c.(601-603)Cga>Tga	p.R201*	ZP3_ENST00000336517.4_5'UTR	NM_080744.1	NP_542782.1	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain containing, group B (4 domains)	201	SRCR 2.					extracellular region|membrane	scavenger receptor activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(9)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21						ATCTCCACTCGGCCCTGACAC	0.711000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604980	179604980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179604980G>A	ENST00000589042.1	-	48	13204	c.12980C>T	c.(12979-12981)tCc>tTc	p.S4327F	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S4010F|TTN_ENST00000342175.6_Missense_Mutation_p.S4156F|TTN_ENST00000359218.5_Missense_Mutation_p.S4089F|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S3964F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4010	Ig-like 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAATCTTAAGGACTTGCCTTC	0.433000													36	88					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52514231	52514231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52514231C>T	ENST00000345716.4	+	13	1582	c.1448C>T	c.(1447-1449)cCc>cTc	p.P483L	NISCH_ENST00000420808.2_Missense_Mutation_p.P483L|NISCH_ENST00000488380.1_Missense_Mutation_p.P483L|NISCH_ENST00000479054.1_Missense_Mutation_p.P483L	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	483	Interaction with PAK1 (By similarity).|Necessary for homooligomerization and targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TCAGCTGCCCCCTGCATCAGA	0.617000													25	82					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87679347	87679347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87679347G>A	ENST00000320005.5	-	6	705	c.658C>T	c.(658-660)Ctg>Ttg	p.L220L		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	220					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AAGAGCCACAGGAGATAGAGT	0.448000													9	31					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98807467	98807467	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98807467G>A	ENST00000266058.4	-	16	1859	c.1614C>T	c.(1612-1614)atC>atT	p.I538I	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.I538I	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	538	LRRNT 3.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TGGACTGGGGGATGCGCTCAG	0.627000													29	71					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239025621	239025621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239025621G>A	ENST00000343063.3	+	5	1196	c.933G>A	c.(931-933)gcG>gcA	p.A311A	ESPNL_ENST00000409169.1_Intron	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	311										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CAGACCTGGCGGAGTACCATG	0.677000													10	17					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3638194	3638194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3638194G>A	ENST00000263087.4	-	21	2670	c.2572C>T	c.(2572-2574)Cta>Tta	p.L858L	ITGAE_ENST00000571185.1_5'UTR	NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	858					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GAGTTAGTTAGGTTAATGTTC	0.463000													23	167					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47222299	47222299	+	Silent	SNP	C	C	T	rs151317740	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:47222299C>T	ENST00000319190.5	+	8	1394	c.1026C>T	c.(1024-1026)atC>atT	p.I342I	TTC7A_ENST00000394850.2_Silent_p.I342I|TTC7A_ENST00000409245.1_Silent_p.I308I|TTC7A_ENST00000263737.6_5'UTR|TTC7A_ENST00000461601.1_3'UTR	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	342							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			AGGACAACATCGAGGAAGCCC	0.597000													15	35					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169494601	169494601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169494601G>A	ENST00000256935.8	+	45	4635	c.4555G>A	c.(4555-4557)Gat>Aat	p.D1519N	DOCK2_ENST00000540750.1_Missense_Mutation_p.D580N|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.D1011N	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1519	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTACCAGAGTGATGAGACCCT	0.493000													29	106					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110842035	110842035	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110842035C>A	ENST00000296632.3	-	3	282	c.148G>T	c.(148-150)Gga>Tga	p.G50*	STARD4_ENST00000502322.1_Nonsense_Mutation_p.G50*|STARD4_ENST00000511569.1_5'UTR|STARD4_ENST00000512160.1_Nonsense_Mutation_p.G50*|STARD4_ENST00000509887.1_Nonsense_Mutation_p.G50*	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	50	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		TACAGATATCCATTAAATTCT	0.303000													8	24					1.58986e-06	1.59347e-06	1	1	0
ALOX5	240	broad.mit.edu	37	10	45877960	45877960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45877960G>A	ENST00000374391.2	+	2	233	c.180G>A	c.(178-180)gaG>gaA	p.E60E	ALOX5_ENST00000542434.1_Silent_p.E60E	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	60	PLAT.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CTGTGGACGAGGAACTGGGCG	0.542000													18	48					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97251363	97251363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97251363C>T	ENST00000389672.5	+	11	2400	c.2362C>T	c.(2362-2364)Cgc>Tgc	p.R788C	EPHA6_ENST00000514100.1_Missense_Mutation_p.R180C|EPHA6_ENST00000502694.1_Missense_Mutation_p.R180C|EPHA6_ENST00000442602.2_Missense_Mutation_p.R154C	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	693	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AAACATCATTCGCCTAGAAGG	0.378000													14	51					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135980	156135980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156135980G>A	ENST00000329476.3	+	2	1378	c.889G>A	c.(889-891)Gtc>Atc	p.V297I	NPY2R_ENST00000506608.1_Missense_Mutation_p.V297I	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	297					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				TGACAGCCAGGTCCTGGACCT	0.522000													13	55					0	0	1	0	0
KRT6B	3854	broad.mit.edu	37	12	52844213	52844213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52844213G>A	ENST00000252252.3	-	2	779	c.732C>T	c.(730-732)gaC>gaT	p.D244D		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	244	Coil 1B.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		CCTCCACCAGGTCCTGCATGT	0.542000													15	173					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35450246	35450246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35450246G>A	ENST00000404801.1	-	4	899	c.513C>T	c.(511-513)ttC>ttT	p.F171F	ZNF792_ENST00000605484.1_Silent_p.F104F	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGTTTGCACTGAACTCAGAGC	0.507000													122	219					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155254414	155254414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155254414G>A	ENST00000357232.3	-	9	1448	c.1449C>T	c.(1447-1449)acC>acT	p.T483T	DCHS2_ENST00000339452.1_Silent_p.T982T|DCHS2_ENST00000507542.1_5'UTR	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	483	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCTCATCCGAGGTCCTGAGGA	0.607000													29	64					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060837	9060837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9060837G>A	ENST00000397910.4	-	3	26812	c.26609C>T	c.(26608-26610)tCc>tTc	p.S8870F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8872	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGATGGTGTGGAATAAAGTGG	0.502000													38	83					0	0	1	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228600	57228600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57228600C>T	ENST00000396721.2	-	2	437	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K	SDR16C5_ENST00000303749.3_Missense_Mutation_p.E103K|SDR16C5_ENST00000522671.1_Missense_Mutation_p.E103K			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	103					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						TACACTCCTTCCTTTTGGCTG	0.448000													35	113					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606458	55606458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55606458C>T	ENST00000378396.1	+	1	231	c.231C>T	c.(229-231)tcC>tcT	p.S77S		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				GCTATTCCTCCATCATTGCTC	0.398000													90	231					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41725476	41725476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41725476G>A	ENST00000400454.1	-	5	1327	c.850C>T	c.(850-852)Cgc>Tgc	p.R284C		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	284	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCCGAGGGGCGAATGTTCTCA	0.542000													26	84					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85926837	85926837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:85926837G>A	ENST00000304195.3	-	8	944	c.738C>T	c.(736-738)gtC>gtT	p.V246V	FRMD3_ENST00000376438.1_Silent_p.V246V|FRMD3_ENST00000376434.1_Silent_p.V52V	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	246	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						TTCCCTGAAAGACCACAAAGC	0.353000													21	61					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	30054429	30054429	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:30054429G>T	ENST00000431530.3	+	8	3415	c.3357G>T	c.(3355-3357)gaG>gaT	p.E1119D	MTUS2_ENST00000542829.1_5'UTR|MTUS2_ENST00000380808.2_Missense_Mutation_p.E88D|MTUS2-AS1_ENST00000323380.4_RNA	NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	1109	Localization to the growing distal tip of microtubules.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TGCAATTCGAGGCGGAAATGG	0.657000													2	2					0.0784	0.0784081	1	1	0
PALD1	27143	broad.mit.edu	37	10	72297607	72297607	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72297607G>A	ENST00000263563.6	+	11	1536	c.1268G>A	c.(1267-1269)tGg>tAg	p.W423*		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		AGGGCGCTGTGGAGCCTGGAG	0.607000													20	76					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67028325	67028325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67028325C>T	ENST00000340001.4	-	10	1580	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K	ABCA9_ENST00000370732.2_Missense_Mutation_p.E457K|ABCA9_ENST00000453985.2_Missense_Mutation_p.E457K	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	457					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GAATCTGTTTCATTCTCAAGG	0.413000													36	74					0	0	1	0	0
TMEM26	219623	broad.mit.edu	37	10	63173294	63173294	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:63173294C>T	ENST00000399298.3	-	5	974		c.e5-1		TMEM26_ENST00000507507.1_5'UTR	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26							integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					AGGACTATTCCTAGAATACAG	0.363000													19	43					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64056670	64056670	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64056670C>T	ENST00000411458.1	+	9	1289	c.1261C>T	c.(1261-1263)Ccc>Tcc	p.P421S	GPR137_ENST00000539851.1_3'UTR|GPR137_ENST00000438980.2_3'UTR|GPR137_ENST00000377702.4_3'UTR|GPR137_ENST00000313074.3_Missense_Mutation_p.P363S	NM_001170726.1	NP_001164197.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	363						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						CAGACGTGATCCCCCTCCCTC	0.647000													30	76					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6948179	6948179	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6948179C>T	ENST00000251761.8	+	0	1954				LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						GGTGCGTCCTCGCTGTGGGCG	0.657000													10	26					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54604068	54604068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54604068G>A	ENST00000474759.1	+	8	873	c.825G>A	c.(823-825)gcG>gcA	p.A275A	CACNA2D3_ENST00000490478.1_Silent_p.A181A|CACNA2D3_ENST00000288197.5_Silent_p.A275A|CACNA2D3_ENST00000415676.2_Silent_p.A275A	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	275	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGACTATCGCGAAGCAAACAG	0.473000													51	108					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5222727	5222727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5222727G>A	ENST00000372412.4	-	18	3312	c.3079C>T	c.(3079-3081)Cgc>Tgc	p.R1027C	PTPRS_ENST00000588012.1_Missense_Mutation_p.R1004C|PTPRS_ENST00000357368.4_Missense_Mutation_p.R1026C|PTPRS_ENST00000353284.2_Intron|PTPRS_ENST00000348075.2_Missense_Mutation_p.R1004C|PTPRS_ENST00000592099.1_Intron|PTPRS_ENST00000588552.1_Intron|PTPRS_ENST00000587303.1_Missense_Mutation_p.R1026C|PTPRS_ENST00000262963.6_Missense_Mutation_p.R1022C			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1026	Fibronectin type-III 7.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GTCCGGTAGCGGACGGGGGGG	0.746000													5	21					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220494888	220494888	+	Missense_Mutation	SNP	C	C	T	rs139813777		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220494888C>T	ENST00000358055.3	+	6	1137	c.625C>T	c.(625-627)Cgg>Tgg	p.R209W	SLC4A3_ENST00000373762.3_Missense_Mutation_p.R236W|SLC4A3_ENST00000273063.6_Missense_Mutation_p.R236W|SLC4A3_ENST00000497589.1_Intron|SLC4A3_ENST00000373760.2_Missense_Mutation_p.R209W|SLC4A3_ENST00000317151.3_Missense_Mutation_p.R209W			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	209					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCAGCCCCCGGGCCCGGGC	0.697000													3	14					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176022630	176022630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176022630G>A	ENST00000510636.1	+	32	4164	c.3890G>A	c.(3889-3891)gGg>gAg	p.G1297E	CDHR2_ENST00000261944.5_Missense_Mutation_p.G1297E|CDHR2_ENST00000506348.1_Missense_Mutation_p.G1297E	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	1297					homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding	p.G1297E(1)		breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CAGCTGGAGGGGCCATCCTAC	0.642000													45	104					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155171641	155171641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:155171641G>A	ENST00000262640.6	+	7	704	c.621G>A	c.(619-621)aaG>aaA	p.K207K	VAMP7_ENST00000460621.1_3'UTR|VAMP7_ENST00000286448.6_3'UTR	NM_001185183.1	NP_001172112.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	0					calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CATTAACCAAGGATATGAGAG	0.413000													11	48					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19195023	19195023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19195023G>A	ENST00000562034.1	+	3	4120	c.322G>A	c.(322-324)Gac>Aac	p.D108N	SYT17_ENST00000568115.1_Missense_Mutation_p.D108N|SYT17_ENST00000562711.2_Missense_Mutation_p.D165N|SYT17_ENST00000355377.2_Missense_Mutation_p.D169N			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	169						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						CTCCAACAGCGACGATGTGGA	0.562000													17	56					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15726098	15726098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15726098G>A	ENST00000378076.3	-	4	826	c.473C>T	c.(472-474)aCt>aTt	p.T158I		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	158					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CGGTTTAAGAGTTCTCCAGTG	0.408000													5	69					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130286841	130286841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130286841C>T	ENST00000257359.6	-	3	1796	c.1090G>A	c.(1090-1092)Gaa>Aaa	p.E364K		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	364	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TTACCTAGTTCATGGGCCAGG	0.572000													75	166					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70946800	70946800	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70946800C>T	ENST00000334414.6	-	21	5188	c.5143_splice	c.e21-1	p.G1715_splice	PTPRB_ENST00000550358.1_Splice_Site_p.G1627_splice|PTPRB_ENST00000261266.5_Splice_Site_p.G1497_splice|PTPRB_ENST00000451516.2_Intron|PTPRB_ENST00000538708.1_Splice_Site_p.G1407_splice|PTPRB_ENST00000550857.1_Splice_Site_p.G1407_splice	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1497	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCATCACTGCCTGGAGGAGA	0.468000													32	128					0	0	1	0	0
AMZ2	51321	broad.mit.edu	37	17	66251903	66251903	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66251903C>T	ENST00000359904.3	+	6	1945	c.813C>T	c.(811-813)ctC>ctT	p.L271L	AMZ2_ENST00000580753.1_Silent_p.L271L|AMZ2_ENST00000585050.1_Intron|AMZ2_ENST00000577985.1_Silent_p.L271L|AMZ2_ENST00000577273.1_Intron|AMZ2_ENST00000392720.2_Silent_p.L271L|AMZ2_ENST00000577866.1_Silent_p.L271L|AMZ2_ENST00000359783.4_Silent_p.L213L	NM_016627.4	NP_057711.3	Q86W34	AMZ2_HUMAN	archaelysin family metallopeptidase 2	271							metallopeptidase activity|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	9	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTGCATGCCTCATGCAAGGCT	0.498000													42	84					0	0	1	0	0
APMAP	57136	broad.mit.edu	37	20	24959427	24959427	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:24959427G>A	ENST00000217456.2	-	3	594	c.304C>T	c.(304-306)Ccg>Tcg	p.P102S	APMAP_ENST00000447138.1_Missense_Mutation_p.P102S	NM_020531.2	NP_065392.1			adipocyte plasma membrane associated protein																		ATGGACTCCGGTCCAACAAGT	0.537000													25	59					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21235097	21235097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21235097G>A	ENST00000233242.1	-	26	4770	c.4643C>T	c.(4642-4644)tCt>tTt	p.S1548F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1548					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGCAGATCAGAGGTGGAGGT	0.433000													25	89					0	0	1	0	0
DMBX1	127343	broad.mit.edu	37	1	46978120	46978120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46978120C>T	ENST00000371956.4	+	4	1118	c.1103C>T	c.(1102-1104)gCc>gTc	p.A368V	DMBX1_ENST00000360032.3_Missense_Mutation_p.A363V	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	368					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					CGGCTCCGGGCCAAGCAGCAC	0.637000													12	119					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139221945	139221945	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139221945C>T	ENST00000274710.3	+	15	2407	c.2202C>T	c.(2200-2202)gcC>gcT	p.A734A		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	734					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGGCTGGCCACTCTGGAAG	0.552000													22	61					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342998	29342998	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29342998G>A	ENST00000396806.3	-	1	70	c.67C>T	c.(67-69)Cct>Tct	p.P23S	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						AAGAAGAAAGGCTGCAGCTCC	0.393000													23	48					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31540725	31540725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31540725C>T	ENST00000454783.1	+	3	378	c.120C>T	c.(118-120)ctC>ctT	p.L40L	LTA_ENST00000418386.2_Silent_p.L40L	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	40					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	GTGTTGGCCTCACACCTTCAG	0.607000													5	51					0	0	1	0	0
FBXO2	26232	broad.mit.edu	37	1	11710068	11710068	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11710068G>A	ENST00000354287.4	-	3	796	c.455C>T	c.(454-456)cCt>cTt	p.P152L		NM_012168.5	NP_036300.2	Q9UK22	FBX2_HUMAN	F-box protein 2	152	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity			kidney(1)|large_intestine(1)|lung(4)	6	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		ACTGTCTCCAGGCAGCTCCTC	0.612000													14	196					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156269057	156269057	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156269057C>T	ENST00000311277.4	-	14	2085	c.1821_splice	c.e14-1	p.E608_splice	AC097467.2_ENST00000601977.1_RNA|MAP9_ENST00000515654.1_Splice_Site_p.E584_splice|AC097467.2_ENST00000595229.1_RNA|AC097467.2_ENST00000597939.1_RNA|AC097467.2_ENST00000593387.1_RNA|AC097467.2_ENST00000598252.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	608					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TCCTTATTTTCCTAAAGAGAA	0.328000													3	7					0	0	1	0	0
GOLGA8IP	283796	broad.mit.edu	37	15	23261824	23261824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23261824G>A	ENST00000450802.3	+	12	1034	c.936G>A	c.(934-936)agG>agA	p.R312R																								AGCACCTGAGGAAGGAACTAG	0.577000													18	92					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65129479	65129479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:65129479C>T	ENST00000371073.2	+	14	2053	c.2053C>T	c.(2053-2055)Ctc>Ttc	p.L685F	CACHD1_ENST00000290039.5_Missense_Mutation_p.L634F|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	685					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CACCGCCTATCTCAGCGACAA	0.587000													34	163					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38964208	38964208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38964208G>A	ENST00000355481.4	+	28	4088	c.3957G>A	c.(3955-3957)gaG>gaA	p.E1319E	RYR1_ENST00000359596.3_Silent_p.E1319E|RYR1_ENST00000360985.3_Silent_p.E1319E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1319	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCCCGCCGAGGACGAGGCCC	0.692000													3	3					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176787	140176787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140176787G>A	ENST00000526136.1	+	1	2238	c.2238G>A	c.(2236-2238)ggG>ggA	p.G746G	PCDHA2_ENST00000378132.1_Silent_p.G746G|PCDHA2_ENST00000520672.2_Silent_p.G746G|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCCGTGGGGAGCTGGTCTT	0.672000													35	67					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24835007	24835007	+	Silent	SNP	G	G	A	rs78374720		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24835007G>A	ENST00000376454.3	+	21	5616	c.5586G>A	c.(5584-5586)ttG>ttA	p.L1862L	KIAA1217_ENST00000376452.3_Silent_p.L1293L|KIAA1217_ENST00000458595.1_Silent_p.L1268L|KIAA1217_ENST00000376462.1_Silent_p.L1183L|KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000396445.1_3'UTR	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1862	Ser-rich.				embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						ATGGCTCTTTGAAGTTTCAGA	0.502000													52	113					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34312544	34312544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34312544C>T	ENST00000373381.4	-	6	1150	c.974G>A	c.(973-975)cGa>cAa	p.R325Q		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	285						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GAAGTGCAGTCGCAGCCAGTT	0.612000													21	47					0	0	1	0	0
CD3D	915	broad.mit.edu	37	11	118211307	118211307	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118211307C>T	ENST00000300692.4	-	2	193	c.55_splice	c.e2-1	p.V19_splice	CD3D_ENST00000392884.2_Splice_Site_p.V19_splice|CD3D_ENST00000529594.1_Intron	NM_000732.4	NP_000723.1	P04234	CD3D_HUMAN	CD3d molecule, delta (CD3-TCR complex)	19					positive thymic T cell selection|T cell costimulation|T cell receptor signaling pathway	cytoplasm|integral to membrane	protein heterodimerization activity			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	9	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		TGAAGGGGCTCACTAAAGGGG	0.463000													8	23					0	0	1	0	0
ATHL1	80162	broad.mit.edu	37	11	291051	291051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:291051C>T	ENST00000409548.2	+	4	959	c.844C>T	c.(844-846)Cct>Tct	p.P282S	ATHL1_ENST00000409479.1_Missense_Mutation_p.P282S|ATHL1_ENST00000409655.1_Missense_Mutation_p.P105S	NM_025092.4	NP_079368.3	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1 (yeast)	282					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|skin(3)	17		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		TGGCCTCAGTCCTGGGGGCCT	0.662000													23	34					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69949067	69949067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:69949067C>T	ENST00000370598.1	+	20	3584	c.2763C>T	c.(2761-2763)atC>atT	p.I921I	BAI3_ENST00000238918.8_Silent_p.I127I	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	921					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GCCTGTCTATCATCTCATCCA	0.353000													48	97					0	0	1	0	0
GPCPD1	56261	broad.mit.edu	37	20	5528378	5528378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5528378G>A	ENST00000379019.4	-	20	2160	c.1948C>T	c.(1948-1950)Ccc>Tcc	p.P650S	GPCPD1_ENST00000481038.1_5'UTR	NM_019593.3	NP_062539.1	Q9NPB8	GPCP1_HUMAN	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	650					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)	16						AAAGATGAGGGAACAAAGCGG	0.458000													66	132					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13830199	13830199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13830199G>A	ENST00000265104.4	-	37	6289	c.6185C>T	c.(6184-6186)tCt>tTt	p.S2062F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2062	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AAAGATAAAAGACTTTTTGTG	0.383000									Kartagener syndrome				13	56					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151167023	151167023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151167023G>A	ENST00000282466.3	-	4	745	c.746C>T	c.(745-747)cCc>cTc	p.P249L		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	249	LRRCT.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGCACTAGAGGGACTTCTATC	0.398000													29	63					0	0	1	0	0
CHAD	1101	broad.mit.edu	37	17	48545818	48545818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48545818G>A	ENST00000508540.1	-	1	509	c.357C>T	c.(355-357)ttC>ttT	p.F119F	ACSF2_ENST00000300441.4_Intron|ACSF2_ENST00000506085.1_Intron|ACSF2_ENST00000541920.1_Intron|CHAD_ENST00000258969.4_Silent_p.F119F|ACSF2_ENST00000502667.1_Intron|ACSF2_ENST00000504392.1_Intron|ACSF2_ENST00000427954.2_Intron	NM_001267.2	NP_001258.2	O15335	CHAD_HUMAN	chondroadherin	119					regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(2)|ovary(2)	15	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TCAGGTCGTCGAAGGCACCTG	0.617000													8	83					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54647985	54647985	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54647985A>T	ENST00000406403.1	+	6	2003	c.400A>T	c.(400-402)Acg>Tcg	p.T134S	CNOT3_ENST00000221232.5_Missense_Mutation_p.T134S|CNOT3_ENST00000358389.3_De_novo_Start_InFrame			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	134					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TACCATCGACACGCTCAACAT	0.557000													17	28					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12726382	12726382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12726382C>T	ENST00000376221.1	+	4	860	c.860C>T	c.(859-861)cCt>cTt	p.P287L		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	287						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TGGCTCAGCCCTGACAACATC	0.512000													47	106					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69758135	69758135	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:69758135G>A	ENST00000370598.1	+	14	2987	c.2166G>A	c.(2164-2166)atG>atA	p.M722I		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	722					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.M722I(1)		NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ACTTTCCAATGAAAGGACGGA	0.368000													36	62					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21196326	21196326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21196326C>T	ENST00000381541.3	+	7	851	c.786C>T	c.(784-786)ttC>ttT	p.F262F	SLCO1B7_ENST00000554957.1_Silent_p.F262F|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Silent_p.F215F|SLCO1B3_ENST00000553473.1_Intron																							GGCTTGGTTTCCTTGTGTCTG	0.353000													54	173					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965048	88965048	+	Missense_Mutation	SNP	G	G	A	rs144693443	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:88965048G>A	ENST00000333190.4	+	4	3361	c.2752G>A	c.(2752-2754)Gga>Aga	p.G918R		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	918						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CACTGCAGAAGGAGAGAGGAC	0.423000										HNSCC(36;0.09)			25	120					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98743903	98743903	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98743903C>T	ENST00000286067.2	+	1	2863	c.2756C>T	c.(2755-2757)tCa>tTa	p.S919L		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	919										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TATCCCAGTTCACTACAGGCT	0.468000													38	84					0	0	1	0	0
KRT33B	3884	broad.mit.edu	37	17	39522755	39522755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39522755C>T	ENST00000251646.3	-	3	604	c.555G>A	c.(553-555)gaG>gaA	p.E185E		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	185	Coil 1B.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				ACAGCAGCTCCTCCTTCAGGG	0.567000													6	76					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54841886	54841886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54841886G>A	ENST00000545554.1	+	27	5874	c.5874G>A	c.(5872-5874)ctG>ctA	p.L1958L	UNC13C_ENST00000537900.1_Silent_p.L1956L|UNC13C_ENST00000260323.11_Silent_p.L1958L			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1958	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TATCCAAACTGAAGGTAATAA	0.358000													41	83					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128957988	128957988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128957988G>A	ENST00000274487.4	+	10	1844	c.1699G>A	c.(1699-1701)Gaa>Aaa	p.E567K	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	567	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CACTGCTGATGAACAATGCCA	0.463000													20	60					0	0	1	0	0
THNSL1	79896	broad.mit.edu	37	10	25313252	25313252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25313252C>T	ENST00000524413.1	+	3	1447	c.1100C>T	c.(1099-1101)cCa>cTa	p.P367L	THNSL1_ENST00000376356.4_Missense_Mutation_p.P367L			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	367					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	CACTGTATCCCACCAAGTTGC	0.388000													36	114					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64668705	64668705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:64668705G>A	ENST00000543942.2	-	11	2186	c.1560C>T	c.(1558-1560)tcC>tcT	p.S520S	RPS11P6_ENST00000535684.1_RNA|C12orf56_ENST00000536975.1_5'UTR|C12orf56_ENST00000333722.5_Silent_p.S360S	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	523										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		TTTGTAGAAAGGACATTATCC	0.353000													18	72					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42145615	42145615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42145615G>A	ENST00000502486.1	-	3	1463	c.884C>T	c.(883-885)tCc>tTc	p.S295F	BEND4_ENST00000504360.1_Missense_Mutation_p.S291F	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	295										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						CGTTGCTGGGGAAGTCCAGCC	0.552000													5	13					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169701980	169701980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169701980G>A	ENST00000333360.7	-	3	336	c.197C>T	c.(196-198)tCa>tTa	p.S66L	SELE_ENST00000367780.4_Missense_Mutation_p.S66L|SELE_ENST00000367781.4_Missense_Mutation_p.S66L|SELE_ENST00000367779.4_Missense_Mutation_p.S66L|SELE_ENST00000367782.4_Missense_Mutation_p.S66L|SELE_ENST00000367777.1_Missense_Mutation_p.S66L|SELE_ENST00000367775.1_Missense_Mutation_p.S66L|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367776.1_Missense_Mutation_p.S66L|SELE_ENST00000367774.1_Missense_Mutation_p.S66L	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	66	C-type lectin.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					ATAACTTGGTGAATAGCTCAA	0.428000													23	79					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152804	18152804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18152804C>T	ENST00000375406.1	+	3	1107	c.891C>T	c.(889-891)gcC>gcT	p.A297A		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	297						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		ACGTGATGGCCTGCGGGGGCA	0.647000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	66					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144994716	144994716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:144994716G>A	ENST00000369356.4	-	1	306	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369347.4_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.R6C	NM_001198834.2|NM_014644.4	NP_001185763.2|NP_055459.4	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	6					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GACAGAGTGCGATATCCATTA	0.567000			T	PDGFRB	MPD								11	125					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119942978	119942978	+	Silent	SNP	G	G	A	rs141348508	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119942978G>A	ENST00000327554.2	+	7	1218	c.753G>A	c.(751-753)caG>caA	p.Q251Q	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	251										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCTCTCCCCAGAGCAGCATGA	0.557000													69	147					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55815961	55815961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55815961G>A	ENST00000309383.1	+	14	1667	c.1390G>A	c.(1390-1392)Gag>Aag	p.E464K	BRSK1_ENST00000326848.7_Missense_Mutation_p.E159K|BRSK1_ENST00000590333.1_Missense_Mutation_p.E480K|BRSK1_ENST00000588584.1_3'UTR	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	464					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GGCTGGAGATGAGGCTCGAGG	0.672000													11	14					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10534239	10534239	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10534239C>T	ENST00000396560.2	+	6	1341	c.1114C>T	c.(1114-1116)Caa>Taa	p.Q372*	ATF7IP2_ENST00000396559.1_Nonsense_Mutation_p.Q372*|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000356427.2_Nonsense_Mutation_p.Q372*|ATF7IP2_ENST00000324570.5_Nonsense_Mutation_p.Q372*	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						AGCAAAACTTCAAAGACGTAT	0.299000													4	32					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22171710	22171710	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22171710C>T	ENST00000397126.4	-	2	153	c.3_splice	c.e2-1	p.G2_splice	ZNF208_ENST00000599916.1_Splice_Site_p.G2_splice|ZNF208_ENST00000597040.1_5'UTR|ZNF208_ENST00000601773.1_Splice_Site_p.G2_splice	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGTCAATGATCCCTGGAAAAC	0.403000													52	156					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6065875	6065875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6065875C>T	ENST00000217289.4	-	12	2219	c.1431G>A	c.(1429-1431)atG>atA	p.M477I	FERMT1_ENST00000478194.1_5'UTR|FERMT1_ENST00000536936.1_Missense_Mutation_p.M220I	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	477	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						AGCTGTCTGCCATGGTTTTGC	0.493000													17	64					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25228723	25228723	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:25228723G>A	ENST00000219660.5	+	2	342	c.217G>A	c.(217-219)Ggg>Agg	p.G73R	AQP8_ENST00000566125.1_Missense_Mutation_p.G67R	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	73					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		CCTGGCCCACGGGCTGGCTTT	0.607000													12	197					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56092314	56092314	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56092314C>T	ENST00000257880.7	-	8	1396	c.1177G>A	c.(1177-1179)Gaa>Aaa	p.E393K	ITGA7_ENST00000347027.6_Missense_Mutation_p.E349K|ITGA7_ENST00000394230.2_Missense_Mutation_p.E353K|ITGA7_ENST00000452168.2_Missense_Mutation_p.E256K|ITGA7_ENST00000553804.1_Missense_Mutation_p.E353K|ITGA7_ENST00000555728.1_Missense_Mutation_p.E393K|ITGA7_ENST00000394229.2_Missense_Mutation_p.E349K|ITGA7_ENST00000257879.6_Missense_Mutation_p.E349K			Q13683	ITA7_HUMAN	integrin, alpha 7	393					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCCAGCTCTTCTTGGCGCTCA	0.612000													38	71					0	0	1	0	0
PRIMA1	145270	broad.mit.edu	37	14	94203637	94203637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94203637G>A	ENST00000393140.1	-	4	411	c.309C>T	c.(307-309)tcC>tcT	p.S103S	PRIMA1_ENST00000316227.3_Silent_p.S103S|PRIMA1_ENST00000393143.1_Silent_p.S103S	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	103					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		GAAACACCAGGGAGGCACAGC	0.537000													13	44					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104122736	104122736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104122736C>T	ENST00000388887.2	+	48	5249	c.5045C>T	c.(5044-5046)tCc>tTc	p.S1682F		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1682	FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AATGCTACTTCCCTCCAAGGA	0.498000													32	83					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41581076	41581076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41581076C>T	ENST00000396942.1	-	8	870	c.787G>A	c.(787-789)Gcc>Acc	p.A263T	ANK1_ENST00000289734.7_Missense_Mutation_p.A263T|ANK1_ENST00000347528.4_Missense_Mutation_p.A263T|ANK1_ENST00000379758.2_Missense_Mutation_p.A263T|ANK1_ENST00000352337.4_Missense_Mutation_p.A263T|ANK1_ENST00000265709.8_Missense_Mutation_p.A296T|ANK1_ENST00000396945.1_Missense_Mutation_p.A263T			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	263	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTATCTGGGCTCCCCGATCC	0.652000													22	100					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821061	43821061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43821061G>A	ENST00000417669.1	+	2	514	c.70G>A	c.(70-72)Ggc>Agc	p.G24S	MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000443721.1_Missense_Mutation_p.G24S|MPPED1_ENST00000542779.1_Missense_Mutation_p.G24S|MPPED1_ENST00000538182.1_Missense_Mutation_p.G57S			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	24							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				CTGCGGCCTGGGCATGGCATT	0.701000													18	19					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73554625	73554625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73554625C>T	ENST00000392550.3	+	5	405	c.288C>T	c.(286-288)agC>agT	p.S96S	LLGL2_ENST00000578363.1_Silent_p.S96S|LLGL2_ENST00000375227.4_Silent_p.S96S|LLGL2_ENST00000167462.5_Silent_p.S96S|LLGL2_ENST00000577200.1_Silent_p.S96S	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	96					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			ATGACAACAGCCTGCACCTTT	0.622000													12	14					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106118213	106118213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106118213G>A	ENST00000369704.3	+	2	258	c.124G>A	c.(124-126)Gaa>Aaa	p.E42K	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	42										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ATTTCGGATTGAATATGAGAG	0.388000													16	53					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35786520	35786520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35786520C>T	ENST00000361922.4	+	4	201	c.51C>T	c.(49-51)tcC>tcT	p.S17S	MAG_ENST00000392213.3_Silent_p.S17S|MAG_ENST00000537831.2_5'UTR|MAG_ENST00000597035.1_Silent_p.S17S	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	17					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCGCAGCCTCCCGAGGGGGTC	0.687000													25	47					0	0	1	0	0
FAM149A	25854	broad.mit.edu	37	4	187086556	187086556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187086556C>T	ENST00000356371.5	+	11	1975	c.1975C>T	c.(1975-1977)Ccc>Tcc	p.P659S	FAM149A_ENST00000389354.5_Missense_Mutation_p.P368S|FAM149A_ENST00000227065.4_Missense_Mutation_p.P368S|FAM149A_ENST00000503432.1_Missense_Mutation_p.P368S|FAM149A_ENST00000502970.1_Missense_Mutation_p.P368S|FAM149A_ENST00000514153.1_Missense_Mutation_p.P368S			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	659										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		GAGCAGGTTCCCCCCGCTAGT	0.537000													19	60					0	0	1	0	0
NR4A3	8013	broad.mit.edu	37	9	102609857	102609857	+	Silent	SNP	C	C	T	rs145134236	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:102609857C>T	ENST00000330847.1	+	6	1670	c.1626C>T	c.(1624-1626)atC>atT	p.I542I	NR4A3_ENST00000395097.2_Silent_p.I531I			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	531					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				ACCTTGATATCCAAGCCTTAG	0.483000			T	EWSR1	extraskeletal myxoid chondrosarcoma								7	79					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729258	62729258	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62729258C>T	ENST00000349451.3	+	5	749	c.337C>T	c.(337-339)Ctg>Ttg	p.L113L	OPRL1_ENST00000336866.2_Silent_p.L113L|OPRL1_ENST00000355631.4_Silent_p.L113L	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	113					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GGACATCCTCCTGGGCTTCTG	0.532000													60	103					0	0	1	0	0
CDAN1	146059	broad.mit.edu	37	15	43026533	43026533	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43026533T>C	ENST00000356231.3	-	7	1171	c.1148A>G	c.(1147-1149)aAc>aGc	p.N383S		NM_138477.2	NP_612486.2	Q8IWY9	CDAN1_HUMAN	codanin 1	383						integral to membrane	protein binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	24		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		TTTGTCCAGGTTGGAAAGAAC	0.557000													15	43					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219483369	219483369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219483369G>A	ENST00000450993.2	+	4	588	c.249G>A	c.(247-249)gaG>gaA	p.E83E	PLCD4_ENST00000432688.1_Silent_p.E83E|PLCD4_ENST00000417849.1_Silent_p.E83E	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	83	PH.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GCCTGGCAGAGGAGCTCCCCC	0.557000													18	38					0	0	1	0	0
OCM	654231	broad.mit.edu	37	7	5925699	5925699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5925699C>T	ENST00000242104.5	+	4	401	c.309C>T	c.(307-309)ttC>ttT	p.F103F	OCM_ENST00000416608.1_Silent_p.F103F	NM_001097622.1	NP_001091091.1	P0CE72	ONCO_HUMAN	oncomodulin	103	EF-hand 2.						calcium ion binding			endometrium(1)|large_intestine(3)|lung(2)	6		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		TTCTAGAATTCCAGGAAATGG	0.493000													23	52					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332825	70332825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70332825C>T	ENST00000338508.4	-	32	3575	c.3576G>A	c.(3574-3576)gcG>gcA	p.A1192A	SHANK2_ENST00000423696.2_Silent_p.A812A|SHANK2_ENST00000409161.1_Silent_p.A595A|SHANK2_ENST00000449833.2_Silent_p.A596A			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	812					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding	p.A596A(1)|p.A1192A(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGCCGCTGCTCGCGGAGGGCA	0.706000													19	64					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120795706	120795706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:120795706G>A	ENST00000369144.3	-	22	4121	c.3994C>T	c.(3994-3996)Ccc>Tcc	p.P1332S	EIF3A_ENST00000541549.1_Missense_Mutation_p.P1298S|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1332					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AGAGCTGGGGGAGGAACTCGA	0.463000													20	100					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238272008	238272008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238272008C>T	ENST00000295550.4	-	14	6403	c.5951G>A	c.(5950-5952)cGa>cAa	p.R1984Q	COL6A3_ENST00000353578.4_Missense_Mutation_p.R1778Q|COL6A3_ENST00000409809.1_Missense_Mutation_p.R1778Q|COL6A3_ENST00000472056.1_Missense_Mutation_p.R1377Q|COL6A3_ENST00000346358.4_Missense_Mutation_p.R1784Q|COL6A3_ENST00000347401.3_Missense_Mutation_p.R1783Q	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1984	Nonhelical region.|VWFA 10.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTTGACCACTCGTTCAAGGCC	0.478000													16	69					0	0	1	0	0
TTLL13	440307	broad.mit.edu	37	15	90799405	90799405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90799405G>A	ENST00000438251.1	+	6	871	c.581G>A	c.(580-582)cGa>cAa	p.R194Q	RP11-697E2.6_ENST00000561573.1_Intron|TTLL13_ENST00000339615.5_Missense_Mutation_p.R194Q			A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	194	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	16	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GGTCGTCAGCGAAAAGCCCGC	0.557000													29	135					0	0	1	0	0
CDH19	28513	broad.mit.edu	37	18	64202268	64202268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:64202268C>T	ENST00000262150.2	-	8	1583	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K	CDH19_ENST00000540086.1_Missense_Mutation_p.E431K	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	431	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				GCACTGATTTCACGATCCAGT	0.328000													14	66					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23901876	23901876	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23901876G>A	ENST00000355349.3	-	5	636	c.474C>T	c.(472-474)tcC>tcT	p.S158S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	158	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGGCGTTGTCGGAGATGGAGA	0.607000													76	141					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111766711	111766711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111766711C>T	ENST00000452346.2	+	7	859	c.856C>T	c.(856-858)Cgt>Tgt	p.R286C	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.R160C			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	286	CUB 1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CTACCTGATTCGTCTCTCAAT	0.527000													27	43					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24834974	24834974	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24834974C>T	ENST00000376454.3	+	21	5583	c.5553C>T	c.(5551-5553)gcC>gcT	p.A1851A	KIAA1217_ENST00000376452.3_Silent_p.A1282A|KIAA1217_ENST00000458595.1_Silent_p.A1257A|KIAA1217_ENST00000376462.1_Silent_p.A1172A|KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000396445.1_3'UTR	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1851	Ser-rich.				embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTCACTCTGCCTCCCTCATCC	0.493000													29	144					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394269	233394269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233394269C>T	ENST00000258229.8	-	5	1573	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	447						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CCATTGCCTTCGGGACAGGGA	0.567000													55	93					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52604151	52604151	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52604151T>A	ENST00000591504.1	-	6	658	c.384A>T	c.(382-384)agA>agT	p.R128S	CCDC68_ENST00000337363.4_Missense_Mutation_p.R128S|CCDC68_ENST00000432185.1_Missense_Mutation_p.R128S	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	128										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		GGGCCACGTTTCTCAGAGCTG	0.428000													9	82					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98209632	98209632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:98209632G>A	ENST00000430669.2	-	23	4293	c.3708C>T	c.(3706-3708)ccC>ccT	p.P1236P	PTCH1_ENST00000421141.1_Silent_p.P1151P|PTCH1_ENST00000331920.6_Silent_p.P1302P|PTCH1_ENST00000429896.2_Silent_p.P1151P|PTCH1_ENST00000418258.1_Silent_p.P1151P|PTCH1_ENST00000375274.2_Silent_p.P1301P|PTCH1_ENST00000437951.1_Silent_p.P1236P			Q13635	PTC1_HUMAN	patched 1	1302					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.P1302H(2)		NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GGTCCCTGCGGGGCTGCTGGC	0.632000													27	69					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17588655	17588655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17588655G>A	ENST00000375460.3	+	3	341	c.301G>A	c.(301-303)Gag>Aag	p.E101K		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	101					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CTCCAGCCATGAGCCTCTGCC	0.547000													15	29					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47777887	47777887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47777887C>T	ENST00000398545.4	-	4	858	c.741G>A	c.(739-741)gcG>gcA	p.A247A		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	247										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GCAGCTGTGTCGCCTGCCTTT	0.557000													28	66					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1891351	1891351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1891351G>A	ENST00000399161.2	-	17	3298	c.2551C>T	c.(2551-2553)Cta>Tta	p.L851L	MYT1L_ENST00000428368.2_Silent_p.L849L	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	851					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTTTCTTCTAGAGCCTCCTGG	0.527000													27	140					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69682041	69682041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69682041G>A	ENST00000265403.7	+	1	331	c.304G>A	c.(304-306)Gat>Aat	p.D102N	UGT2B10_ENST00000458688.2_Missense_Mutation_p.D102N	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	102					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						AATTCAAAAAGATACATTTTG	0.289000													28	97					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27197330	27197330	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27197330G>A	ENST00000380036.4	+	12	2084	c.1642G>A	c.(1642-1644)Ggt>Agt	p.G548S	TEK_ENST00000519097.1_Missense_Mutation_p.G401S|TEK_ENST00000406359.4_Missense_Mutation_p.G505S	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	548	Fibronectin type-III 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TCCTCCAAGAGGTCTAAATCT	0.398000													32	86					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30966408	30966408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:30966408G>A	ENST00000295055.8	-	13	1462	c.1286C>T	c.(1285-1287)tCg>tTg	p.S429L	CAPN13_ENST00000534090.2_Missense_Mutation_p.S429L	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	429					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GTTTCTGAACGAGGAAAAAAA	0.473000													10	88					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739037	38739037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38739037C>T	ENST00000449082.2	-	27	5673	c.5674G>A	c.(5674-5676)Gaa>Aaa	p.E1892K		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1892					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACAAAACCTTCATCTGGGAGT	0.502000													53	94					0	0	1	0	0
LILRA6	79168	broad.mit.edu	37	19	54746066	54746066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54746066C>T	ENST00000440558.2	-	3	239	c.191G>A	c.(190-192)gGa>gAa	p.G64E	LILRA6_ENST00000270464.5_Missense_Mutation_p.G64E|LILRA6_ENST00000245621.5_Missense_Mutation_p.G64E|LILRA6_ENST00000396365.2_Missense_Mutation_p.G64E|LILRA6_ENST00000419410.2_Missense_Mutation_p.G64E|LILRB3_ENST00000407860.2_Missense_Mutation_p.G64E|LILRA6_ENST00000391735.3_Missense_Mutation_p.G64E					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTCTGGGCTTCCCTCTTTATC	0.587000													79	355					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102175092	102175092	+	Missense_Mutation	SNP	G	G	A	rs149996665		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:102175092G>A	ENST00000306176.1	+	4	531	c.431G>A	c.(430-432)gGa>gAa	p.G144E	ZPLD1_ENST00000466937.1_Missense_Mutation_p.G128E|ZPLD1_ENST00000491959.1_Missense_Mutation_p.G128E	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	128	ZP.					integral to membrane		p.G144E(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GTGCAAGTAGGAAATATTTCA	0.358000													48	102					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43627933	43627933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:43627933C>T	ENST00000378069.4	-	14	1525	c.1378G>A	c.(1378-1380)Gat>Aat	p.D460N	MAOB_ENST00000536181.1_Missense_Mutation_p.D444N|MAOB_ENST00000538942.1_Missense_Mutation_p.G411E	NM_000898.4	NP_000889.3	P27338	AOFB_HUMAN	monoamine oxidase B	460					xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(2)|skin(5)	21					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	CAGATTTCATCCTCTGGAATC	0.398000													23	18					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234072440	234072440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234072440C>T	ENST00000359570.5	+	14	1292	c.1292C>T	c.(1291-1293)cCc>cTc	p.P431L	INPP5D_ENST00000538935.1_Missense_Mutation_p.P430L|INPP5D_ENST00000455936.2_Missense_Mutation_p.P195L|INPP5D_ENST00000450745.1_Missense_Mutation_p.P195L			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	443					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GACTACATCCCCCATGACATT	0.557000													31	138					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48055274	48055274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48055274C>T	ENST00000316364.5	+	9	1159	c.720C>T	c.(718-720)atC>atT	p.I240I	SEMA6D_ENST00000558014.1_Silent_p.I240I|SEMA6D_ENST00000389432.2_Silent_p.I240I|SEMA6D_ENST00000389428.3_Silent_p.I240I|SEMA6D_ENST00000358066.4_Silent_p.I240I|SEMA6D_ENST00000536845.2_Silent_p.I240I|SEMA6D_ENST00000537942.1_Silent_p.I240I|SEMA6D_ENST00000354744.4_Silent_p.I240I|SEMA6D_ENST00000389433.2_Silent_p.I240I|SEMA6D_ENST00000558816.1_Silent_p.I240I|SEMA6D_ENST00000389425.3_Silent_p.I240I|SEMA6D_ENST00000355997.3_Silent_p.I240I	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	240	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTCGAGAAATCGCTGTCGAAC	0.358000													4	34					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33374802	33374802	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:33374802C>T	ENST00000303296.4	+	17	3641	c.3336C>T	c.(3334-3336)ctC>ctT	p.L1112L	HIPK3_ENST00000525975.1_Silent_p.L1091L|HIPK3_ENST00000456517.1_Silent_p.L1091L|HIPK3_ENST00000379016.3_Silent_p.L1091L	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	1112					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						ATACACACCTCGGAGGACAGC	0.507000													16	87					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8483425	8483425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8483425C>T	ENST00000447869.1	-	4	1403	c.485G>A	c.(484-486)cGa>cAa	p.R162Q	STK33_ENST00000396673.1_Missense_Mutation_p.R162Q|STK33_ENST00000315204.1_Missense_Mutation_p.R162Q|STK33_ENST00000396672.1_Missense_Mutation_p.R162Q|STK33_ENST00000358872.3_5'UTR|STK33_ENST00000534493.1_Missense_Mutation_p.R121Q			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	162	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		GTTCACCTCTCGTTCAAGTAA	0.363000													33	84					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115544823	115544823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:115544823G>A	ENST00000310836.6	+	2	1309	c.787G>A	c.(787-789)Gga>Aga	p.G263R	UGT8_ENST00000394511.3_Missense_Mutation_p.G263R	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	263					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TTATGTAGGAGGAATCCTAAC	0.423000													33	72					0	0	1	0	0
TMEM109	79073	broad.mit.edu	37	11	60689298	60689298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60689298C>T	ENST00000227525.3	+	4	796	c.393C>T	c.(391-393)ttC>ttT	p.F131F	RP11-881M11.4_ENST00000543907.1_RNA|TMEM109_ENST00000536171.1_Silent_p.F131F	NM_024092.2	NP_076997.1	Q9BVC6	TM109_HUMAN	transmembrane protein 109	131						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8						TCCAGACCTTCCTGCTGTGGG	0.632000													54	108					0	0	1	0	0
ATG13	9776	broad.mit.edu	37	11	46686987	46686987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:46686987C>T	ENST00000434074.1	+	12	1644	c.955C>T	c.(955-957)Cat>Tat	p.H319Y	ATG13_ENST00000312040.4_Missense_Mutation_p.H319Y|ATG13_ENST00000524625.1_Missense_Mutation_p.H282Y|ATG13_ENST00000529655.1_Missense_Mutation_p.H282Y|ATG13_ENST00000451945.1_Missense_Mutation_p.H282Y|ATG13_ENST00000528494.1_Missense_Mutation_p.H352Y|ATG13_ENST00000526508.1_Missense_Mutation_p.H319Y|ATG13_ENST00000359513.4_Missense_Mutation_p.H319Y|ATG13_ENST00000530500.1_Missense_Mutation_p.H203Y	NM_001205120.1	NP_001192049.1	O75143	ATG13_HUMAN	autophagy related 13	319					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	15						CCAGCCTGTCCATGGTACCCA	0.562000													25	45					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100330034	100330034	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100330034T>C	ENST00000294724.4	+	5	1031	c.553T>C	c.(553-555)Ttt>Ctt	p.F185L	AGL_ENST00000370163.3_Missense_Mutation_p.F185L|AGL_ENST00000370161.2_Missense_Mutation_p.F169L|AGL_ENST00000361302.3_Missense_Mutation_p.F169L|AGL_ENST00000361522.4_Missense_Mutation_p.F168L|AGL_ENST00000361915.3_Missense_Mutation_p.F185L|AGL_ENST00000370165.3_Missense_Mutation_p.F185L	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	185					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		AAATCCTGACTTTTCAAGACC	0.363000													28	116					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179643967	179643967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179643967G>A	ENST00000589042.1	-	23	4176	c.3952C>T	c.(3952-3954)Cca>Tca	p.P1318S	RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P1318S|TTN_ENST00000360870.5_Missense_Mutation_p.P1318S|TTN_ENST00000591111.1_Missense_Mutation_p.P1318S|TTN_ENST00000342175.6_Missense_Mutation_p.P1272S|TTN_ENST00000359218.5_Missense_Mutation_p.P1272S|TTN_ENST00000460472.2_Missense_Mutation_p.P1272S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1318	Ig-like 5.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTAATGGATATCCAGAC	0.303000													20	48					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275666	130275666	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130275666G>T	ENST00000257359.6	-	9	3163	c.2457C>A	c.(2455-2457)agC>agA	p.S819R		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	819	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CTCTCTCTTTGCTGCTCTGCA	0.577000													63	191					7.55815e-43	7.61189e-43	1	1	0
CD93	22918	broad.mit.edu	37	20	23066017	23066017	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23066017G>T	ENST00000246006.4	-	1	960	c.813C>A	c.(811-813)tgC>tgA	p.C271*		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	271	EGF-like 1.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					AGTCCTGGTGGCAGCCCCCAT	0.627000													39	114					5.43694e-19	5.46898e-19	1	1	0
CTAG2	30848	broad.mit.edu	37	X	153880896	153880896	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153880896C>T	ENST00000247306.4	-	2	342	c.279G>A	c.(277-279)acG>acA	p.T93T	CTAG2_ENST00000369585.3_Silent_p.T93T	NM_020994.3	NP_066274.1	O75638	CTAG2_HUMAN	cancer/testis antigen 2	93						centrosome				central_nervous_system(1)|endometrium(1)|lung(6)|ovary(1)|pancreas(1)	10	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGAAAGGCATCGTGATGTGCC	0.642000													23	19					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628475	71628475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71628475C>T	ENST00000377276.2	-	1	564	c.534G>A	c.(532-534)caG>caA	p.Q178Q		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	178	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						GCAGGTAGCCCTGCTGGTCGA	0.632000													7	25					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	650775	650775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:650775G>A	ENST00000255622.6	+	9	1263	c.1220G>A	c.(1219-1221)gGg>gAg	p.G407E	PDE6B_ENST00000429163.2_Missense_Mutation_p.G128E|PDE6B_ENST00000496514.1_Missense_Mutation_p.G407E	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	407	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						AGGAAAGACGGGAAGCCCTTT	0.587000													26	51					0	0	1	0	0
NDUFV1	4723	broad.mit.edu	37	11	67379625	67379625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67379625C>T	ENST00000322776.6	+	9	1350	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	NDUFV1_ENST00000415352.2_Silent_p.F392F|NDUFV1_ENST00000529927.1_Silent_p.F390F|NDUFV1_ENST00000532303.1_Silent_p.F298F	NM_001166102.1|NM_007103.3	NP_001159574.1|NP_009034.2	P49821	NDUV1_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	399					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	16					NADH(DB00157)	TGGCACGTTTCGTGAGGGGGG	0.622000													49	102					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119911838	119911838	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119911838T>A	ENST00000464295.1	-	5	867	c.422A>T	c.(421-423)aAg>aTg	p.K141M	GPR156_ENST00000461057.1_Missense_Mutation_p.K141M|GPR156_ENST00000315843.3_Missense_Mutation_p.K141M			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	141						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		TCGCCAGCTCTTTCCCAGAAT	0.512000													20	84					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902356	51902356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:51902356G>A	ENST00000268919.4	+	1	2118	c.1962G>A	c.(1960-1962)gaG>gaA	p.E654E		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	654					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CTCTGACCGAGATCCAAAAGA	0.448000													12	50					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13185134	13185134	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13185134C>T	ENST00000379345.2	+	5	574	c.333C>T	c.(331-333)ttC>ttT	p.F111F	PHACTR1_ENST00000457702.2_Intron|PHACTR1_ENST00000379350.1_Intron|PHACTR1_ENST00000332995.7_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	50						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CTGCTGCTTTCCCTGGAGACC	0.577000													9	119					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150715859	150715859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150715859G>A	ENST00000605938.1	-	6	1641	c.1566C>T	c.(1564-1566)ccC>ccT	p.P522P	ATG9B_ENST00000377974.2_Silent_p.P522P|ATG9B_ENST00000444312.1_Intron|ATG9B_ENST00000494791.1_5'UTR	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	522					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCGTGCGCAGGGGCGCGGGGG	0.741000													3	6					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26586715	26586715	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26586715T>A	ENST00000436318.2	-	2	905	c.772A>T	c.(772-774)Aaa>Taa	p.K258*	ANO3_ENST00000537978.1_Intron|MUC15_ENST00000281268.8_Nonsense_Mutation_p.K258*|ANO3_ENST00000256737.3_Intron|MUC15_ENST00000527569.1_Nonsense_Mutation_p.K258*|MUC15_ENST00000455601.2_Nonsense_Mutation_p.K231*|ANO3_ENST00000525139.1_Intron|MUC15_ENST00000529533.1_Nonsense_Mutation_p.K258*|ANO3_ENST00000531568.1_Intron			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	231						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						TATTTACCTTTTTGGGGATCT	0.338000													23	105					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15600105	15600105	+	Missense_Mutation	SNP	C	C	T	rs138187704		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15600105C>T	ENST00000378076.3	-	26	3087	c.2734G>A	c.(2734-2736)Gaa>Aaa	p.E912K		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	912					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CTGTGGAATTCGACCACATGT	0.498000													33	101					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140227901	140227901	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140227901G>A	ENST00000378122.3	+	0	545				PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_De_novo_Start_OutOfFrame|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTTGCCGCGATGTTCTCTC	0.393000													11	4					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87678058	87678058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:87678058C>T	ENST00000284262.2	+	2	819	c.577C>T	c.(577-579)Cgc>Tgc	p.R193C		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	193					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		GGCCGTGTCCCGCGGGGGCTT	0.687000													32	62					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199156	118199156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:118199156G>A	ENST00000425217.1	-	4	613	c.559C>T	c.(559-561)Ccc>Tcc	p.P187S	KSR2_ENST00000339824.5_Missense_Mutation_p.P216S	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	216	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGGCCCCGGGAGTGGGGCTG	0.706000													12	22					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25789932	25789932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25789932C>T	ENST00000399878.3	-	13	2253	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	SEL1L3_ENST00000502949.1_Missense_Mutation_p.E558K|SEL1L3_ENST00000264868.5_Missense_Mutation_p.E676K	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	711						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						ATTGCTGCTTCGGGATTCTTG	0.463000													40	115					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184104544	184104544	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184104544G>A	ENST00000204604.1	+	16	2442		c.e16+1		EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000545352.1_Intron|CHRD_ENST00000348986.3_Splice_Site|CHRD_ENST00000450923.1_Splice_Site	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin						BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CACCTGCCAGGTAGGAGGTCC	0.657000													4	10					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39358846	39358846	+	Missense_Mutation	SNP	G	G	A	rs121434355		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39358846G>A	ENST00000280481.7	+	6	6136	c.5920G>A	c.(5920-5922)Gag>Aag	p.E1974K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1974	Calx-beta 2.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTACGAGGAGGAGGAAACCTT	0.498000													35	59					0	0	1	0	0
FOXD4L5	653427	broad.mit.edu	37	9	70177179	70177179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:70177179G>A	ENST00000377420.1	-	1	1636	c.805C>T	c.(805-807)Cgc>Tgc	p.R269C		NM_001126334.1	NP_001119806.1	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	269					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|lung(2)	7						AGTAGGTAGCGAAGAGGATGC	0.706000													8	26					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185698093	185698093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:185698093G>A	ENST00000515030.1	-	6	847	c.522C>T	c.(520-522)atC>atT	p.I174I	ACSL1_ENST00000507295.1_Silent_p.I140I|ACSL1_ENST00000504900.1_Silent_p.I174I|ACSL1_ENST00000504342.1_Silent_p.I174I|ACSL1_ENST00000454703.2_Silent_p.I3I|ACSL1_ENST00000437665.3_Silent_p.I3I|ACSL1_ENST00000281455.2_Silent_p.I174I|ACSL1_ENST00000513317.1_Silent_p.I174I			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	174					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AAAGTGGAACGATCACCATCG	0.388000													4	46					0	0	1	0	0
TBX6	6911	broad.mit.edu	37	16	30097955	30097955	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30097955T>C	ENST00000395224.2	-	8	1034	c.975A>G	c.(973-975)gaA>gaG	p.E325E	TBX6_ENST00000279386.2_Silent_p.E325E	NM_004608.3	NP_004599.2	O95947	TBX6_HUMAN	T-box 6	325					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						CTGGGGCCTGTTCTGGATCTG	0.662000													3	11					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6239815	6239815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6239815C>T	ENST00000400104.3	-	9	809	c.609G>A	c.(607-609)agG>agA	p.R203R	L3MBTL4_ENST00000400105.2_Silent_p.R203R|L3MBTL4_ENST00000535782.1_Silent_p.R16R|L3MBTL4_ENST00000284898.6_Silent_p.R203R|L3MBTL4_ENST00000317931.7_Silent_p.R203R			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	203					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				AAGGGTTCTTCCTGTCCACGG	0.463000													24	68					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933907	44933907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44933907C>T	ENST00000291187.4	-	6	1353	c.1031G>A	c.(1030-1032)aGa>aAa	p.R344K	ZNF229_ENST00000588931.1_Missense_Mutation_p.R350K|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GACATCACATCTATAGGGCAT	0.507000													12	124					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28711559	28711559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28711559C>T	ENST00000257197.3	-	15	2746	c.2485G>A	c.(2485-2487)Gaa>Aaa	p.E829K	RP11-408H20.3_ENST00000582307.1_RNA|DSC1_ENST00000257198.5_Missense_Mutation_p.E829K|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	829					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GAACTTACTTCGCCAAGCCGA	0.453000													24	96					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99308381	99308381	+	Missense_Mutation	SNP	C	C	T	rs147031398		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99308381C>T	ENST00000336374.2	-	10	1002	c.1000G>A	c.(1000-1002)Gaa>Aaa	p.E334K		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	334					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					GTATCAATTTCCTTCTGCACT	0.453000													22	69					0	0	1	0	0
TRBV5-7	28608	broad.mit.edu	37	7	142111471	142111471	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142111471G>A	ENST00000390378.1	-	0	264																											CTATAGTTAGGGAACTGGTGA	0.517000													52	88					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57872937	57872937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57872937C>T	ENST00000393797.2	-	5	658	c.466G>A	c.(466-468)Gag>Aag	p.E156K	ARHGAP9_ENST00000550288.1_Missense_Mutation_p.E164K|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.E85K|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.E85K|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.E85K			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	85					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			ATGGATTCCTCTATCATATAG	0.557000													10	118					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626490	49626490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49626490G>A	ENST00000371571.4	-	2	671	c.386C>T	c.(385-387)aCc>aTc	p.T129I	RP5-955M13.4_ENST00000424566.1_RNA|KCNG1_ENST00000396017.3_Missense_Mutation_p.T129I	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	129						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GCGCAGGAAGGTCAGGATAGT	0.632000													23	61					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79399106	79399106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79399106G>A	ENST00000264895.6	+	55	8429	c.7989G>A	c.(7987-7989)gcG>gcA	p.A2663A		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2658	Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCACCCAGGCGAAGGTCATTA	0.458000													5	23					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117221501	117221501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:117221501G>A	ENST00000355044.3	+	22	3499	c.3373G>A	c.(3373-3375)Gat>Aat	p.D1125N	ATRNL1_ENST00000303745.7_Intron|ATRNL1_ENST00000423111.2_Missense_Mutation_p.D176N	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1125						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ACAGGAAGATGATCGCCACCA	0.323000													11	72					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43918417	43918417	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43918417G>A	ENST00000336086.6	-	4	2752	c.516C>T	c.(514-516)ctC>ctT	p.L172L	URGCP_ENST00000447717.3_Silent_p.L172L|URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000402306.3_Silent_p.L206L|URGCP_ENST00000453200.1_Silent_p.L215L|URGCP_ENST00000443736.1_Silent_p.L172L|RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000223341.7_Silent_p.L172L			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	215					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CAGGCAACACGAGTGGGAGTG	0.562000													11	29					0	0	1	0	0
ANKZF1	55139	broad.mit.edu	37	2	220099597	220099597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220099597G>A	ENST00000323348.5	+	10	1428	c.1254G>A	c.(1252-1254)gtG>gtA	p.V418V	ANKZF1_ENST00000409849.1_Silent_p.V208V|ANKZF1_ENST00000410034.3_Silent_p.V418V	NM_018089.2	NP_060559.2	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing 1	418						intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	23		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGAGCTAGTGGAGTTGACTG	0.498000													17	64					0	0	1	0	0
SH2D3A	10045	broad.mit.edu	37	19	6760821	6760821	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6760821C>T	ENST00000245908.6	-	3	516	c.247G>A	c.(247-249)Gag>Aag	p.E83K	SH2D3A_ENST00000437152.3_Intron|SH2D3A_ENST00000599563.1_5'UTR	NM_005490.2	NP_005481.2	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	83	SH2.				JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|urinary_tract(1)	24						GGGAATTGCTCATCCTCCAGT	0.637000													20	54					0	0	1	0	0
SOX7	83595	broad.mit.edu	37	8	10583582	10583582	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10583582G>A	ENST00000304501.1	-	2	911	c.833C>T	c.(832-834)cCc>cTc	p.P278L	SOX7_ENST00000554914.1_Missense_Mutation_p.P330L|SOX7_ENST00000553390.1_Missense_Mutation_p.P330L	NM_031439.2	NP_113627.1	Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	278	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		AGGAGATGGGGGACAGCCGGG	0.677000													16	27					0	0	1	0	0
TNPO3	23534	broad.mit.edu	37	7	128615975	128615975	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128615975G>T	ENST00000393245.1	-	17	2551	c.2178C>A	c.(2176-2178)taC>taA	p.Y726*	TNPO3_ENST00000471166.1_Nonsense_Mutation_p.Y726*|TNPO3_ENST00000265388.5_Nonsense_Mutation_p.Y692*|TNPO3_ENST00000482320.1_Nonsense_Mutation_p.Y626*|TNPO3_ENST00000471234.1_Nonsense_Mutation_p.Y628*	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	692					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						GATGTACGTGGTACACATTCA	0.458000													19	49					1.28384e-07	1.28746e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179407830	179407830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179407830C>T	ENST00000589042.1	-	347	97094	c.96870G>A	c.(96868-96870)gaG>gaA	p.E32290E	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Silent_p.E29722E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Silent_p.E30649E|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Silent_p.E23417E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.E23350E|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.E23225E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30649	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTGACAGTCTCTCTTGGTT	0.368000													95	207					0	0	1	0	0
NOMO3	408050	broad.mit.edu	37	16	16349589	16349589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16349589G>A	ENST00000399336.4	+	10	1148	c.976G>A	c.(976-978)Gtc>Atc	p.V326I	NOMO3_ENST00000538468.1_Missense_Mutation_p.V159I|NOMO3_ENST00000263012.6_Missense_Mutation_p.V326I	NM_001004067.3	NP_001004067.1	P69849	NOMO3_HUMAN	NODAL modulator 3	326						integral to membrane	carbohydrate binding|carboxypeptidase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	8				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CGTGTTCCACGTCATGGGATT	0.557000													20	55					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146720077	146720077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:146720077C>T	ENST00000392299.2	+	8	2372	c.1902C>T	c.(1900-1902)atC>atT	p.I634I	GRM1_ENST00000355289.4_Silent_p.I634I|GRM1_ENST00000492807.2_Silent_p.I634I|GRM1_ENST00000282753.1_Silent_p.I634I|GRM1_ENST00000507907.1_Silent_p.I634I|GRM1_ENST00000361719.2_Silent_p.I634I			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	634					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GCTACATCATCCTAGCTGGCA	0.522000													81	97					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5540286	5540286	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5540286G>A	ENST00000382368.3	-	3	1737	c.1614C>T	c.(1612-1614)ctC>ctT	p.L538L	FBXL18_ENST00000453700.3_Silent_p.L538L	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	538									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GCAGCTGTGCGAGCGTCAGGT	0.687000													11	19					0	0	1	0	0
AP3M2	10947	broad.mit.edu	37	8	42015560	42015560	+	Silent	SNP	C	C	T	rs113481990		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42015560C>T	ENST00000518421.1	+	4	666	c.375C>T	c.(373-375)acC>acT	p.T125T	AP3M2_ENST00000174653.3_Silent_p.T125T|AP3M2_ENST00000520685.1_Intron|AP3M2_ENST00000396926.3_Silent_p.T125T|AP3M2_ENST00000517922.1_Silent_p.T125T	NM_001134296.1	NP_001127768.1	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	125					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus				endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|stomach(1)	17	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			CATTGGCTACCGAGTCGAACA	0.428000													15	114					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78758726	78758726	+	Missense_Mutation	SNP	G	G	A	rs143720317		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78758726G>A	ENST00000258886.8	+	5	673	c.524G>A	c.(523-525)cGa>cAa	p.R175Q	IREB2_ENST00000559427.1_3'UTR|IREB2_ENST00000560440.1_Missense_Mutation_p.R175Q	NM_004136.2	NP_004127.1	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	175							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		ACTACCTGCCGAGGATCTTGT	0.498000													46	60					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47571021	47571021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47571021G>A	ENST00000253048.5	-	15	2541	c.2504C>T	c.(2503-2505)tCa>tTa	p.S835L	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	835							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CTCCCCAACTGAAGCCGGGGG	0.652000													3	13					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2040160	2040160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2040160G>A	ENST00000250896.3	-	13	1371	c.1127C>T	c.(1126-1128)aCc>aTc	p.T376I	MKNK2_ENST00000588014.1_Missense_Mutation_p.T120I|MKNK2_ENST00000591588.1_Missense_Mutation_p.T120I|MKNK2_ENST00000591601.1_Missense_Mutation_p.T376I|MKNK2_ENST00000591142.1_Missense_Mutation_p.T120I|MKNK2_ENST00000541165.1_Missense_Mutation_p.T245I|MKNK2_ENST00000309340.7_Missense_Mutation_p.T376I	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	376	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTGGGCAAGGTGTTCTCCGG	0.677000													3	8					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64427844	64427844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64427844C>T	ENST00000265459.6	-	11	2810	c.2349G>A	c.(2347-2349)ctG>ctA	p.L783L	NRXN2_ENST00000377551.1_Silent_p.L783L|NRXN2_ENST00000409571.1_Silent_p.L776L|NRXN2_ENST00000377559.3_Silent_p.L752L	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	783	Laminin G-like 4.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CATCCAGCTCCAGGCGTAGGG	0.617000													9	72					0	0	1	0	0
C10orf62	414157	broad.mit.edu	37	10	99349560	99349560	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:99349560G>A	ENST00000370640.3	+	0	111				PI4K2A_ENST00000370649.3_Intron|HOGA1_ENST00000370647.4_Intron|PI4K2A_ENST00000555577.1_Intron|HOGA1_ENST00000370646.4_Intron	NM_001009997.2	NP_001009997.2	Q5T681	CJ062_HUMAN	chromosome 10 open reading frame 62								protein binding			endometrium(2)|kidney(1)|lung(1)	4		Colorectal(252;0.162)		Epithelial(162;9.58e-11)|all cancers(201;8.62e-09)		CTGCCTGCCTGGTGTAGGGTC	0.592000													6	41					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20801753	20801753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20801753C>T	ENST00000359062.3	+	13	2737	c.2697C>T	c.(2695-2697)ttC>ttT	p.F899F	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	899	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ATTTCCGTTTCCTTGTCATTG	0.403000													24	102					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169362547	169362547	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169362547G>A	ENST00000511577.1	-	10	1482	c.1235C>T	c.(1234-1236)tCt>tTt	p.S412F	DDX60L_ENST00000505890.1_Missense_Mutation_p.S412F|DDX60L_ENST00000260184.7_Missense_Mutation_p.S412F			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	412							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CAGAGGAAAAGACTTTCCAAC	0.373000													20	95					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55012584	55012584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:55012584C>T	ENST00000371336.3	+	2	602	c.401C>T	c.(400-402)cCc>cTc	p.P134L	CASS4_ENST00000360314.3_Missense_Mutation_p.P134L|CASS4_ENST00000434344.1_Missense_Mutation_p.P134L	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	134					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						TATGAATTCCCCGACCCTCCC	0.572000													53	115					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29275126	29275126	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29275126C>T	ENST00000377160.2	+	1	724	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						TTCGCATCTTCTCTACAGTGC	0.468000													51	160					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919520	4919520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4919520C>T	ENST00000433855.1	+	1	1179	c.313C>T	c.(313-315)Cgc>Tgc	p.R105C	KCNA6_ENST00000280684.3_Missense_Mutation_p.R105C	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	105						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GTCTGGGGGCCGCCTGCGGAG	0.657000										HNSCC(72;0.22)			45	68					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27465590	27465590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27465590C>T	ENST00000264705.4	+	41	6487	c.6325C>T	c.(6325-6327)Ctg>Ttg	p.L2109L	CAD_ENST00000403525.1_Silent_p.L2046L	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	2109	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	ACCTCCCAGCCTGCGCATGCC	0.652000													6	72					0	0	1	0	0
BZW2	28969	broad.mit.edu	37	7	16714053	16714053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:16714053C>T	ENST00000433922.2	+	3	253	c.75C>T	c.(73-75)ttC>ttT	p.F25F	BZW2_ENST00000258761.3_Silent_p.F25F|BZW2_ENST00000405202.1_5'UTR|BZW2_ENST00000452975.2_Silent_p.F25F	NM_001159767.1	NP_001153239.1	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	25					cell differentiation|nervous system development|RNA metabolic process		protein binding	p.F25F(1)		cervix(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	15	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		AAGAGAAATTCGAACCCACAG	0.333000													37	102					0	0	1	0	0
SIM2	6493	broad.mit.edu	37	21	38098611	38098611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38098611G>A	ENST00000290399.6	+	6	1348	c.735G>A	c.(733-735)ctG>ctA	p.L245L	SIM2_ENST00000430056.3_Silent_p.L245L	NM_005069.3	NP_005060.1	Q14190	SIM2_HUMAN	single-minded family bHLH transcription factor 2	245	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(2)	16						TGATATTCCTGGATTCCAGGT	0.562000													9	21					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117310547	117310547	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117310547C>T	ENST00000321322.6	-	22	4149	c.4148G>A	c.(4147-4149)tGg>tAg	p.W1383*	DSCAML1_ENST00000527706.1_Nonsense_Mutation_p.W1113*	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1323	Fibronectin type-III 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTCCTTGGTCCACTTCACAGC	0.567000													45	186					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3328402	3328402	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3328402C>T	ENST00000378398.3	+	10	1726	c.1644C>T	c.(1642-1644)ctC>ctT	p.L548L	PRDM16_ENST00000378391.2_Silent_p.L547L|PRDM16_ENST00000442529.2_Silent_p.L547L|PRDM16_ENST00000441472.2_Silent_p.L547L|PRDM16_ENST00000514189.1_Silent_p.L548L|PRDM16_ENST00000511072.1_Silent_p.L548L|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Silent_p.L547L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	547	Pro-rich.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ACGCCAAGCTCCCCAGTCCCC	0.682000			T	EVI1	"""MDS, AML"""								47	105					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196718101	196718101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196718101G>A	ENST00000312428.6	-	46	8847	c.8747C>T	c.(8746-8748)gCt>gTt	p.A2916V		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2916					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCGAGGTAAGCAACCACTCC	0.507000													6	59					0	0	1	0	0
WNT16	51384	broad.mit.edu	37	7	120979048	120979048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120979048G>A	ENST00000222462.2	+	4	1037	c.747G>A	c.(745-747)ttG>ttA	p.L249L	WNT16_ENST00000361301.2_Silent_p.L239L	NM_057168.1	NP_476509.1	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family, member 16	249					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)	18	all_neural(327;0.117)					GCCATTTGTTGAAGGATAAAT	0.413000													22	44					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102270432	102270432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:102270432G>A	ENST00000370103.4	-	6	952	c.739C>T	c.(739-741)Cgt>Tgt	p.R247C	OLFM3_ENST00000338858.5_Missense_Mutation_p.R267C|OLFM3_ENST00000536598.1_3'UTR|OLFM3_ENST00000462354.1_5'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	267	Olfactomedin-like.					extracellular region		p.R267S(1)|p.R247S(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TTGTATTCACGAACAATTTTA	0.378000													30	68					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8619417	8619417	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8619417C>T	ENST00000338257.8	-	4	537	c.270G>A	c.(268-270)acG>acA	p.T90T		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	90	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						ACATGTTGTCCGTGAGGGCGT	0.622000													35	123					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940519	113940519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113940519G>A	ENST00000245796.6	+	2	681	c.486G>A	c.(484-486)caG>caA	p.Q162Q	PSD4_ENST00000441564.2_Silent_p.Q162Q|PSD4_ENST00000465917.1_3'UTR	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	162					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCATCCTGCAGGCCCAGATGT	0.617000													6	84					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32187941	32187941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32187941G>A	ENST00000375023.3	-	7	1418	c.1280C>T	c.(1279-1281)cCc>cTc	p.P427L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	427	EGF-like 10.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GTGGCAGGTGGGCCCCGAATA	0.612000													15	39					0	0	1	0	0
TRAV30	28652	broad.mit.edu	37	14	22636798	22636798	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22636798C>T	ENST00000557168.1	+	0	251																											ATATCTGCTTCATTTAATGAA	0.468000													22	47					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45949718	45949718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45949718C>T	ENST00000323084.4	-	5	818	c.753G>A	c.(751-753)ggG>ggA	p.G251G	TSPEAR_ENST00000397916.1_Silent_p.G183G	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	251					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CTTCTGGCTTCCCCGTGAGAG	0.642000													30	54					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87457444	87457444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:87457444G>A	ENST00000268616.4	-	4	618	c.401C>T	c.(400-402)tCc>tTc	p.S134F		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	134					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CACTTCAGAGGAAGATTTGGT	0.368000													31	61					0	0	1	0	0
FBXO28	23219	broad.mit.edu	37	1	224340893	224340893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:224340893C>T	ENST00000366862.5	+	4	609	c.566C>T	c.(565-567)gCc>gTc	p.A189V	FBXO28_ENST00000424254.2_Intron	NM_015176.3	NP_055991.1	Q9NVF7	FBX28_HUMAN	F-box protein 28	189										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(2)|skin(1)	10	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		TCTACCAGAGCCCCTCAACGA	0.323000													22	81					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32636195	32636195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:32636195C>T	ENST00000335185.5	-	16	1712	c.1669G>A	c.(1669-1671)Gga>Aga	p.G557R		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	557										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					ACATCTAATCCTCTGGTTCTT	0.294000													11	30					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96952164	96952164	+	Silent	SNP	G	G	A	rs143175658		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96952164G>A	ENST00000323853.5	-	29	3965	c.3888C>T	c.(3886-3888)ccC>ccT	p.P1296P	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1296						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CGGTTGGAGGGGGGTACTTCT	0.502000													32	101					0	0	1	0	0
ZNF736	728927	broad.mit.edu	37	7	63809132	63809132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:63809132C>T	ENST00000355095.4	+	5	1213	c.891C>T	c.(889-891)ttC>ttT	p.F297F	ZNF736_ENST00000423484.1_Silent_p.F297F	NM_001170905.1	NP_001164376.1	B4DX44	ZN736_HUMAN	zinc finger protein 736	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|stomach(1)|urinary_tract(1)	9						ATAGGTGGTTCTCAGACCTTG	0.378000													7	19					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94574247	94574247	+	Nonsense_Mutation	SNP	G	G	A	rs61748531		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94574247G>A	ENST00000370225.3	-	4	414	c.328C>T	c.(328-330)Caa>Taa	p.Q110*	ABCA4_ENST00000535735.1_Nonsense_Mutation_p.Q110*	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	110					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AGGAGTTCTTGAAAATCTCGA	0.418000													24	46					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124740999	124740999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124740999C>T	ENST00000397801.1	+	7	1315	c.1123C>T	c.(1123-1125)Cca>Tca	p.P375S	ROBO3_ENST00000538940.1_Missense_Mutation_p.P353S	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	375	Ig-like C2-type 4.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		AGGAAACCCCCCACCTGCCAT	0.632000													11	53					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10404786	10404786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10404786C>T	ENST00000226207.5	-	27	3473	c.3379G>A	c.(3379-3381)Gag>Aag	p.E1127K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1127						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CGCTCTGCCTCGATTTCCTCC	0.542000													30	32					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74357718	74357718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74357718G>A	ENST00000226355.3	+	8	1066	c.973G>A	c.(973-975)Gat>Aat	p.D325N		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	325	Albumin 2.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TAGACCAAAGGATTTATCTCT	0.378000													36	92					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207751310	207751310	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207751310C>T	ENST00000367049.4	+	29	4698	c.4698C>T	c.(4696-4698)acC>acT	p.T1566T	CR1_ENST00000400960.2_Silent_p.T1116T|CR1_ENST00000367052.1_Silent_p.T1116T|CR1_ENST00000367053.1_Silent_p.T1116T|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367051.1_Silent_p.T1116T|RP11-78B10.2_ENST00000597497.1_RNA	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1116	Sushi 24.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TATACTGCACCAGCAATGACG	0.493000													53	119					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74429805	74429805	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74429805G>A	ENST00000376332.3	-	2	651	c.155C>T	c.(154-156)cCa>cTa	p.P52L	CHRDL2_ENST00000263671.5_Missense_Mutation_p.P52L|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	52	VWFC 1.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					CAGGCCTTGTGGCTCCAAGTA	0.577000													8	25					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216896	21216896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21216896C>T	ENST00000380216.1	-	1	414	c.409G>A	c.(409-411)Gag>Aag	p.E137K		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	137					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		ATGGAGTCCTCATTCATCAGG	0.468000													31	294					0	0	1	0	0
PMEPA1	56937	broad.mit.edu	37	20	56234689	56234689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56234689G>A	ENST00000341744.3	-	2	493	c.174C>T	c.(172-174)atC>atT	p.I58I	PMEPA1_ENST00000472841.1_5'UTR|PMEPA1_ENST00000395814.1_Silent_p.I8I|PMEPA1_ENST00000395816.3_Silent_p.I8I|PMEPA1_ENST00000265626.4_Silent_p.I8I|PMEPA1_ENST00000347215.4_Silent_p.I23I	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	58					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GCAGGCACGTGatcaccacca	0.577000													3	12					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477323	88477323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:88477323G>A	ENST00000267549.3	+	2	690	c.132G>A	c.(130-132)aaG>aaA	p.K44K	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	44					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TGCAAGCAAAGAAGGAAAGTG	0.368000													11	123					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56388240	56388240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:56388240G>A	ENST00000423270.1	-	9	1685	c.1686C>T	c.(1684-1686)ccC>ccT	p.P562P	RFX7_ENST00000317318.6_Silent_p.P562P|RFX7_ENST00000559447.2_Silent_p.P465P|RFX7_ENST00000422057.1_Silent_p.P465P	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	465					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TAGGTGTCTGGGGAGCTTTAG	0.473000													6	16					0	0	1	0	0
SULT1B1	27284	broad.mit.edu	37	4	70620411	70620411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70620411G>A	ENST00000310613.2	-	3	551	c.254C>T	c.(253-255)aCt>aTt	p.T85I		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1	85					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol				breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						TCCAGGGAGAGTCATTTCCAA	0.303000													46	133					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	108518795	108518795	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:108518795G>A	ENST00000375915.2	-	1	288	c.150C>T	c.(148-150)gtC>gtT	p.V50V		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	50						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CAGAGAGCAGGACTGTGAAAA	0.597000													48	135					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192190	211192190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:211192190C>T	ENST00000271751.4	-	6	994	c.967G>A	c.(967-969)Ggt>Agt	p.G323S	KCNH1_ENST00000367007.4_Intron			O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	323					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCTGGATCACCCATAAAGGCA	0.468000													38	129					0	0	1	0	0
SPATA9	83890	broad.mit.edu	37	5	94994441	94994441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94994441C>T	ENST00000274432.8	-	5	792	c.651G>A	c.(649-651)ccG>ccA	p.P217P	RFESD_ENST00000508206.1_Intron|SPATA9_ENST00000477047.2_Intron	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	217					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		CTGGCTTCTCCGGCAATGACC	0.403000													29	51					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53232924	53232924	+	Silent	SNP	C	C	T	rs140251181		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53232924C>T	ENST00000359499.4	-	9	1217	c.1206G>A	c.(1204-1206)tcG>tcA	p.S402S	KRT78_ENST00000304620.4_Silent_p.S512S			Q8N1N4	K2C78_HUMAN	keratin 78	512	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						TCTTCAGACTCGACTCAACTG	0.582000													9	16					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126219690	126219690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126219690C>T	ENST00000290868.2	-	11	1046	c.993G>A	c.(991-993)acG>acA	p.T331T	UROC1_ENST00000383579.3_Silent_p.T391T	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	331					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		ACTCCCCCGTCGTGTCCAATT	0.647000													12	47					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103629630	103629630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103629630G>A	ENST00000424685.2	-	1	333	c.174C>T	c.(172-174)tcC>tcT	p.S58S	RELN_ENST00000343529.5_Silent_p.S58S|RELN_ENST00000428762.1_Silent_p.S58S			P78509	RELN_HUMAN	reelin	58	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAATATGCAGGGAAATGAGCA	0.652000													15	60					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3188392	3188392	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3188392C>T	ENST00000355072.5	+	38	5080	c.4935C>T	c.(4933-4935)tcC>tcT	p.S1645S		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1645					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCCCTTCCTCCCTCCGTCCGG	0.468000													69	174					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141597566	141597566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141597566G>A	ENST00000389484.3	-	31	6174	c.5203C>T	c.(5203-5205)Cca>Tca	p.P1735S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1735					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTACCAACTGGCTCCTTCTGA	0.328000										TSP Lung(27;0.18)			6	28					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169374	90169374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:90169374C>T	ENST00000333209.3	-	2	2406	c.1888G>A	c.(1888-1890)Gcc>Acc	p.A630T		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	630										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		CGTGGGCTGGCTTTGACGGAG	0.582000													40	83					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76712688	76712688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76712688G>A	ENST00000369950.3	-	12	1427	c.1238C>T	c.(1237-1239)cCt>cTt	p.P413L	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	413					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTCAACAGGAGGAAGTTCTGG	0.423000													11	38					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57970781	57970781	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57970781G>A	ENST00000302592.6	-	1	872	c.873C>T	c.(871-873)ttC>ttT	p.F291F		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				TCACCACAGTGAATAGGACAG	0.453000													60	123					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102376371	102376371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:102376371C>T	ENST00000369138.1	+	13	2439	c.1949C>T	c.(1948-1950)tCg>tTg	p.S650L	GRIK2_ENST00000413795.1_Missense_Mutation_p.S650L|GRIK2_ENST00000369134.4_Missense_Mutation_p.S601L|GRIK2_ENST00000369137.3_Missense_Mutation_p.S574L|GRIK2_ENST00000318991.6_Missense_Mutation_p.S650L|GRIK2_ENST00000421544.1_Missense_Mutation_p.S650L	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	650					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	ATCATTTCTTCGTATACTGCT	0.448000													29	31					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105361807	105361807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105361807G>A	ENST00000369774.4	-	15	3444	c.3168C>T	c.(3166-3168)tcC>tcT	p.S1056S	SH3PXD2A_ENST00000355946.2_Silent_p.S1028S|SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000538130.1_Silent_p.S891S|SH3PXD2A_ENST00000540321.1_Silent_p.S923S|SH3PXD2A_ENST00000427662.2_Intron			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	1056					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GGCGCACAGGGGACACGGGTA	0.627000													52	129					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47942791	47942791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47942791C>T	ENST00000402813.3	-	9	1002	c.860G>A	c.(859-861)cGa>cAa	p.R287Q	CNGA1_ENST00000514170.1_Missense_Mutation_p.R218Q|CNGA1_ENST00000544810.1_Missense_Mutation_p.R218Q|CNGA1_ENST00000420489.2_Missense_Mutation_p.R218Q|CNGA1_ENST00000358519.4_Missense_Mutation_p.R218Q			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	218					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity	p.R218Q(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						TGTCCTTGTTCGTACAAACAT	0.294000													22	57					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423464	56423464	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56423464G>A	ENST00000588751.1	-	5	1743	c.1719C>T	c.(1717-1719)gtC>gtT	p.V573V	NLRP13_ENST00000342929.3_Silent_p.V573V			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	573							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TGTCAAGCAAGACGTGTTGCA	0.418000													40	109					0	0	1	0	0
TJP2	9414	broad.mit.edu	37	9	71864319	71864319	+	Missense_Mutation	SNP	G	G	A	rs150494393		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71864319G>A	ENST00000377245.4	+	20	3117	c.2909G>A	c.(2908-2910)cGa>cAa	p.R970Q	TJP2_ENST00000539225.1_Missense_Mutation_p.R1001Q|TJP2_ENST00000453658.2_Intron|TJP2_ENST00000348208.4_Intron|TJP2_ENST00000535702.1_Intron	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	970					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						CCAGAGCCACGAGCTCAGATG	0.542000													8	21					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66942707	66942707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:66942707G>A	ENST00000374690.3	+	7	3012	c.2488G>A	c.(2488-2490)Gaa>Aaa	p.E830K	AR_ENST00000396044.3_Intron|AR_ENST00000396043.2_Missense_Mutation_p.E298K	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	829	Interaction with MYST2.|Ligand-binding.		L -> P (in prostate cancer).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	ATTCTTTGATGAACTTCGAAT	0.443000									Androgen Insensitivity Syndrome				4	16					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30551997	30551997	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30551997C>T	ENST00000326195.8	+	13	1243	c.1131C>T	c.(1129-1131)gtC>gtT	p.V377V	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Silent_p.V339V	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	377	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						CACCAGCAGTCCAGGCTGTTC	0.552000													6	65					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34004285	34004285	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34004285C>T	ENST00000374181.3	-	8	1771	c.1602G>A	c.(1600-1602)aaG>aaA	p.K534K	GRM4_ENST00000455714.2_Silent_p.K394K|GRM4_ENST00000535756.1_Silent_p.K401K|GRM4_ENST00000544773.1_Silent_p.K365K|GRM4_ENST00000545715.1_Silent_p.K226K|GRM4_ENST00000374177.3_Silent_p.K418K|GRM4_ENST00000538487.1_Silent_p.K534K	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	534					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	AAGGCATGCCCTTCACTGTCT	0.642000													18	47					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10408708	10408708	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10408708G>A	ENST00000226207.5	-	20	2389	c.2295C>T	c.(2293-2295)acC>acT	p.T765T	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	765	Actin-binding (By similarity).|Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						ATATTACCTTGGTGTGACCAA	0.408000													44	81					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111156379	111156379	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111156379G>A	ENST00000280325.4	+	4	458	c.309_splice	c.e4-1	p.R104_splice		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	104										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		TCTCCTCAGAGGGACTCATGG	0.587000													9	69					0	0	1	0	0
DPAGT1	1798	broad.mit.edu	37	11	118967876	118967876	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118967876G>A	ENST00000409993.2	-	10	2688	c.1137C>T	c.(1135-1137)ctC>ctT	p.L379L	DPAGT1_ENST00000432443.2_Silent_p.L272L|DPAGT1_ENST00000354202.4_Silent_p.L379L			Q9H3H5	GPT_HUMAN	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	379					dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	17	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		GGAGCAATGTGAGGTTTCTCT	0.473000													65	137					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41012789	41012789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41012789C>T	ENST00000399564.4	-	30	3481	c.3031G>A	c.(3031-3033)Gaa>Aaa	p.E1011K	MROH2B_ENST00000506092.2_Missense_Mutation_p.E566K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TCCAGCATTTCCTCTAGGAAC	0.458000													25	81					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	57005376	57005376	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57005376G>A	ENST00000179765.5	-	8	1760	c.1561C>T	c.(1561-1563)Cgt>Tgt	p.R521C	BAZ2A_ENST00000551812.1_Missense_Mutation_p.R553C|BAZ2A_ENST00000549884.1_Missense_Mutation_p.R551C|BAZ2A_ENST00000379441.3_Missense_Mutation_p.R523C			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	553					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						AGGGGAAGACGAACTTCTTCT	0.418000													12	29					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655781	19655781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19655781C>T	ENST00000586018.1	+	8	2547	c.2445C>T	c.(2443-2445)gtC>gtT	p.V815V	CILP2_ENST00000291495.4_Silent_p.V809V			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	809						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						CCGCCCTGGTCACCGCCACCC	0.746000													8	15					0	0	1	0	0
SPARCL1	8404	broad.mit.edu	37	4	88415108	88415108	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88415108A>T	ENST00000418378.1	-	5	1415	c.844T>A	c.(844-846)Tcg>Acg	p.S282T	SPARCL1_ENST00000503414.1_Missense_Mutation_p.S157T|SPARCL1_ENST00000282470.6_Missense_Mutation_p.S282T	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	282					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TTGACGTTCGATGCATTTTCC	0.413000													125	316					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585475	82585475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82585475C>T	ENST00000423517.2	-	5	5131	c.4794G>A	c.(4792-4794)aaG>aaA	p.K1598K	PCLO_ENST00000333891.8_Silent_p.K1598K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1529					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGCCTTTTCCCTTTGTTTCTT	0.433000													52	173					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76735651	76735651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76735651C>T	ENST00000287239.4	+	8	2045	c.1556C>T	c.(1555-1557)cCc>cTc	p.P519L	KAT6B_ENST00000372714.1_Intron|KAT6B_ENST00000372725.1_Intron|KAT6B_ENST00000372711.1_Intron|KAT6B_ENST00000372724.1_Intron	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	519	Negatively regulates HAT activity.|Ser-rich.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										TCTCCCTCTCCCCAGAGTTCT	0.547000													35	86					0	0	1	0	0
CCKBR	887	broad.mit.edu	37	11	6290997	6290997	+	Missense_Mutation	SNP	C	C	T	rs148924129		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6290997C>T	ENST00000525462.1	+	2	253	c.250C>T	c.(250-252)Cgc>Tgc	p.R84C	CCKBR_ENST00000531712.1_3'UTR|CCKBR_ENST00000525014.1_Missense_Mutation_p.R84C|CCKBR_ENST00000334619.2_Missense_Mutation_p.R84C|CCKBR_ENST00000532715.1_Intron			P32239	GASR_HUMAN	cholecystokinin B receptor	84					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	ACTGAGCCGCCGCCTGAGGAC	0.552000													30	84					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77671544	77671544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:77671544C>T	ENST00000461745.1	+	23	4621	c.3721C>T	c.(3721-3723)Cct>Tct	p.P1241S	ROBO2_ENST00000487694.3_Missense_Mutation_p.P1257S|ROBO2_ENST00000332191.8_Missense_Mutation_p.P1241S	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1241					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GGACCAGACTCCTGGATCCAG	0.448000													19	43					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105174832	105174832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105174832C>T	ENST00000369797.3	+	12	1536	c.1442C>T	c.(1441-1443)cCt>cTt	p.P481L		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	481	S1 motif 5.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GGCCTGGTACCTCCCATGCAC	0.537000													22	44					0	0	1	0	0
LOXL3	84695	broad.mit.edu	37	2	74763927	74763927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74763927C>T	ENST00000264094.3	-	5	892	c.821G>A	c.(820-822)gGg>gAg	p.G274E	LOXL3_ENST00000409986.1_Intron|LOXL3_ENST00000409549.1_Missense_Mutation_p.G274E|LOXL3_ENST00000393937.2_Intron|LOXL3_ENST00000409249.1_Missense_Mutation_p.G274E	NM_032603.2	NP_115992.1	P58215	LOXL3_HUMAN	lysyl oxidase-like 3	274	SRCR 2.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity			endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30						TGCAGGGCCCCCCCCAGGGCA	0.642000													44	95					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519885	69519885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69519885G>A	ENST00000338206.5	-	5	1192	c.1183C>T	c.(1183-1185)Ccc>Tcc	p.P395S		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	395					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										GCAAACAAGGGAATGCCCACC	0.463000													27	254					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43771241	43771241	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43771241G>A	ENST00000389420.3	-	32	4921	c.4922C>T	c.(4921-4923)cCt>cTt	p.P1641L		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1641	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGAGAGGAAGGCACCACAGG	0.408000													5	35					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61498026	61498026	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61498026C>T	ENST00000424789.2	+	25	4687	c.4683C>T	c.(4681-4683)ccC>ccT	p.P1561P	TANC2_ENST00000389520.4_Silent_p.P1571P|RP11-269G24.3_ENST00000583552.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1561							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CTGGTTCACCCGTGCGCTATC	0.582000													10	29					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45561771	45561771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45561771C>T	ENST00000415258.1	+	18	2416	c.2275C>T	c.(2275-2277)Ctc>Ttc	p.L759F	LARS2_ENST00000467936.1_3'UTR|LARS2_ENST00000265537.3_Missense_Mutation_p.L759F|LARS2_ENST00000414984.1_Missense_Mutation_p.L716F			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	759					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	GCTGATGGGACTCAGCAATGC	0.493000													13	98					0	0	1	0	0
NTN5	126147	broad.mit.edu	37	19	49167855	49167855	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49167855G>A	ENST00000270235.4	-	3	896	c.801C>T	c.(799-801)ttC>ttT	p.F267F	SEC1P_ENST00000430145.2_RNA	NM_145807.1	NP_665806.1	Q8WTR8	NET5_HUMAN	netrin 5	267	Laminin EGF-like 2.					extracellular region		p.F267L(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	10						CCCTGCGGCTGAAGATAGGCT	0.682000													9	39					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332551	100332551	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:100332551G>A	ENST00000341853.1	-	0	1640				AC090825.1_ENST00000408584.1_RNA	NR_003260.1																						GCCGTCGGAGGGACCTCAGCG	0.582000													14	129					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153430313	153430313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153430313C>T	ENST00000368723.3	-	3	385	c.275G>A	c.(274-276)gGa>gAa	p.G92E	S100A7_ENST00000368722.1_Missense_Mutation_p.G92E	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	92					angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGCGCTGCTCCATGGCTCTG	0.517000													33	86					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66482982	66482982	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:66482982C>T	ENST00000359626.5	+	6	877	c.713C>T	c.(712-714)tCc>tTc	p.S238F		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	238					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				AAGTTCATCTCCCAGCTGCAG	0.547000													19	32					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77300426	77300426	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77300426G>C	ENST00000376896.2	+	10	1884	c.1272G>C	c.(1270-1272)ggG>ggC	p.G424G	RORB_ENST00000396204.2_Silent_p.G435G	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	435	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						ACTTGCACGGGGAGAAGCTGC	0.478000													41	125					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052768	15052768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15052768C>T	ENST00000248072.3	+	1	468	c.468C>T	c.(466-468)tcC>tcT	p.S156S		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TCATGGGTTCCTTGCTTGAGA	0.522000													78	172					0	0	1	0	0
HAPLN3	145864	broad.mit.edu	37	15	89430486	89430486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89430486G>A	ENST00000359595.3	-	2	258	c.44C>T	c.(43-45)tCc>tTc	p.S15F	HAPLN3_ENST00000562889.1_Missense_Mutation_p.S77F	NM_178232.2	NP_839946.1	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	15					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	17	Lung NSC(78;0.0392)|all_lung(78;0.077)					CAGTCCGTAGGAGCCGGGCAG	0.642000													41	55					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53222763	53222763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53222763G>A	ENST00000394729.2	+	15	1771	c.1443G>A	c.(1441-1443)ctG>ctA	p.L481L	PRKCD_ENST00000330452.3_Silent_p.L481L	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	481	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		ATGTGCTGCTGGACCGGGATG	0.557000													44	62					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531962	42531962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:42531962C>T	ENST00000282030.5	+	4	2953	c.2657C>T	c.(2656-2658)tCa>tTa	p.S886L		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	886						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GAGAAGAGCTCAGAATCCCGA	0.582000									Schinzel-Giedion syndrome				7	33					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348866	220348866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220348866G>A	ENST00000312358.7	+	30	6813	c.6681G>A	c.(6679-6681)aaG>aaA	p.K2227K	SPEG_ENST00000485813.1_3'UTR|AC053503.11_ENST00000429882.1_RNA	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2227	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GAGCCTCCAAGCCTGCACCAC	0.667000													13	54					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17452296	17452296	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17452296C>T	ENST00000324894.8	+	9	1331	c.1263C>T	c.(1261-1263)gaC>gaT	p.D421D	GTPBP3_ENST00000361619.5_Silent_p.D443D|GTPBP3_ENST00000598038.1_3'UTR|GTPBP3_ENST00000600625.1_Silent_p.D400D|GTPBP3_ENST00000358792.7_Silent_p.D453D	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	421					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						GGTGTGGGGACCCGTCCACAG	0.557000													21	64					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105423001	105423001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105423001G>A	ENST00000333244.5	-	4	358	c.239C>T	c.(238-240)tCt>tTt	p.S80F		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	80						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTCCCAGCAGAACCTTGCCT	0.617000													36	92					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440346	40440346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40440346C>T	ENST00000319592.4	-	4	1274	c.565G>A	c.(565-567)Gac>Aac	p.D189N	RBM47_ENST00000381793.2_Missense_Mutation_p.D189N|RBM47_ENST00000381795.6_Missense_Mutation_p.D189N|RBM47_ENST00000295971.7_Missense_Mutation_p.D189N|RBM47_ENST00000514014.1_Missense_Mutation_p.D151N|RBM47_ENST00000515809.1_Intron			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	189	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						TTCATCTTGTCGGCCGCGCTG	0.647000													41	70					0	0	1	0	0
TXNDC15	79770	broad.mit.edu	37	5	134229308	134229308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134229308C>T	ENST00000358387.4	+	3	1343	c.718C>T	c.(718-720)Ctt>Ttt	p.L240F	TXNDC15_ENST00000546290.1_Missense_Mutation_p.L217F	NM_024715.3	NP_078991.3	Q96J42	TXD15_HUMAN	thioredoxin domain containing 15	240	Thioredoxin.				cell redox homeostasis	integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATTTCCAGCTCTTCACTTTTT	0.522000													48	141					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64748576	64748576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:64748576G>A	ENST00000536360.1	-	5	1614	c.801C>T	c.(799-801)ggC>ggT	p.G267G				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	267	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TGTCTTTGCGGCCATGGTAGC	0.378000													39	111					0	0	1	0	0
ZNF618	114991	broad.mit.edu	37	9	116811507	116811507	+	Missense_Mutation	SNP	C	C	T	rs141487834	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116811507C>T	ENST00000288466.7	+	14	1745	c.1646C>T	c.(1645-1647)tCg>tTg	p.S549L	ZNF618_ENST00000470105.1_3'UTR|ZNF618_ENST00000374126.5_Missense_Mutation_p.S642L	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	642					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						GCCTTGAACTCGGTGGTGCAG	0.642000													7	57					0	0	1	0	0
ACTR3C	653857	broad.mit.edu	37	7	149986573	149986573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149986573G>A	ENST00000539352.1	-	4	514	c.263C>T	c.(262-264)cCt>cTt	p.P88L	ACTR3C_ENST00000252071.4_Missense_Mutation_p.P88L	NM_001164458.1	NP_001157930.1	Q9C0K3	ARP3C_HUMAN	ARP3 actin-related protein 3 homolog C (yeast)	88					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding										TGACTGCTCAGGAGGGATTCC	0.483000													4	20					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53932330	53932330	+	Missense_Mutation	SNP	G	G	A	rs141793483	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53932330G>A	ENST00000371445.3	+	4	1079	c.1024G>A	c.(1024-1026)Gac>Aac	p.D342N		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	342					sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						GGAGCAGTCCGACTAGGCCCC	0.567000													96	199					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26915838	26915838	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:26915838C>T	ENST00000231021.4	-	3	595	c.423G>A	c.(421-423)ccG>ccA	p.P141P		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	141	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						ATTCCGATTCCGGTTCCACCT	0.398000													68	186					0	0	1	0	0
SYT8	90019	broad.mit.edu	37	11	1856416	1856416	+	Silent	SNP	C	C	T	rs144532203	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1856416C>T	ENST00000535046.1	+	2	537	c.537C>T	c.(535-537)gtC>gtT	p.V179V	SYT8_ENST00000341958.3_Silent_p.V27V|SYT8_ENST00000381968.3_Silent_p.V41V|SYT8_ENST00000436964.2_Silent_p.V27V			Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	41	C2 1.					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CAGACCTTGTCGCCGGGACCC	0.622000													26	46					0	0	1	0	0
CLDN14	23562	broad.mit.edu	37	21	37833526	37833526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37833526C>T	ENST00000399137.1	-	3	1334	c.468G>A	c.(466-468)atG>atA	p.M156I	AP000695.4_ENST00000428667.1_RNA|CLDN14_ENST00000342108.2_Missense_Mutation_p.M156I|CLDN14_ENST00000399139.1_Missense_Mutation_p.M156I|CLDN14_ENST00000399136.1_Missense_Mutation_p.M156I|AP000695.6_ENST00000429588.1_RNA|CLDN14_ENST00000399135.1_Missense_Mutation_p.M156I	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	156					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						TCTCAAACTTCATGCCGCTGG	0.622000													28	64					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72724649	72724649	+	Missense_Mutation	SNP	G	G	A	rs146519251		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72724649G>A	ENST00000377182.4	+	4	1051	c.434G>A	c.(433-435)gGt>gAt	p.G145D	MAMDC2-AS1_ENST00000591368.1_RNA|MAMDC2-AS1_ENST00000414515.3_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	145	MAM 1.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						TTAATAGAAGGTGTACTAGGA	0.403000													23	154					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42375933	42375933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42375933C>T	ENST00000290472.3	-	7	610	c.516G>A	c.(514-516)ggG>ggA	p.G172G		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	172					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		CAGCGGTGCTCCCTGTGCTGT	0.627000													55	101					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97475240	97475240	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97475240G>A	ENST00000377075.2	+	7	2412	c.2314G>A	c.(2314-2316)Gag>Aag	p.E772K	CNNM4_ENST00000540067.1_3'UTR	NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	772					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						AGCCTCCCACGAGAATGCCAT	0.612000													14	28					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111430622	111430622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:111430622G>A	ENST00000428084.1	-	31	3478	c.3206C>T	c.(3205-3207)cCc>cTc	p.P1069L	DOCK4_ENST00000437633.1_Missense_Mutation_p.P1069L			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1069					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TTCTAGGAAGGGGCCAATCAG	0.403000													4	37					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20141519	20141519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20141519G>A	ENST00000375121.2	-	1	252	c.76C>T	c.(76-78)Cct>Tct	p.P26S	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	26						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCCAGCAGGGGCCACAGCG	0.652000													36	68					0	0	1	0	0
C15orf43	145645	broad.mit.edu	37	15	45249110	45249110	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45249110G>A	ENST00000340827.3	+	2	98	c.81G>A	c.(79-81)acG>acA	p.T27T		NM_152448.2	NP_689661.1	Q8NHR7	CO043_HUMAN	chromosome 15 open reading frame 43	27										NS(1)|breast(2)|large_intestine(1)|lung(2)|skin(2)	8		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		AAGGGGGAACGATCAGTGACC	0.587000													9	70					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13206217	13206217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13206217C>T	ENST00000379350.1	+	7	964	c.835C>T	c.(835-837)Ctg>Ttg	p.L279L	PHACTR1_ENST00000457702.2_Silent_p.L134L|PHACTR1_ENST00000379345.2_Intron|PHACTR1_ENST00000332995.7_Silent_p.L279L			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	279						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CCACACTGTCCTGCCCTCCCA	0.662000													29	57					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25255689	25255689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25255689G>A	ENST00000400358.4	+	9	865	c.808G>A	c.(808-810)Gac>Aac	p.D270N	SGSM1_ENST00000400359.4_Missense_Mutation_p.D270N	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	270						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						GCAGAGGGACGACATGGAGGC	0.562000													20	57					0	0	1	0	0
ZNF221	7638	broad.mit.edu	37	19	44470696	44470696	+	Missense_Mutation	SNP	C	C	T	rs150319141	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44470696C>T	ENST00000251269.5	+	6	1370	c.1042C>T	c.(1042-1044)Cgt>Tgt	p.R348C	ZNF221_ENST00000592350.1_Missense_Mutation_p.R348C|ZNF221_ENST00000587682.1_Missense_Mutation_p.R348C	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				CAAGAACTTTCGTCAGAGATC	0.408000													37	190					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12384283	12384283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12384283G>A	ENST00000356109.5	-	5	1049	c.931C>T	c.(931-933)Cct>Tct	p.P311S	ZNF44_ENST00000355684.5_Missense_Mutation_p.P263S	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		CTGTAATCAGGGAAGGCTTTA	0.408000													59	169					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33475234	33475234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:33475234C>T	ENST00000265371.4	-	15	2770	c.2245G>A	c.(2245-2247)Gat>Aat	p.D749N	NRP1_ENST00000395995.1_Missense_Mutation_p.D749N|NRP1_ENST00000374867.2_Missense_Mutation_p.D749N			O14786	NRP1_HUMAN	neuropilin 1	749	MAM.			D -> H (in Ref. 2; AAC12921).	axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	ACCAGCTGATCGTACTCCTCT	0.542000													20	50					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21793124	21793124	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21793124C>A	ENST00000206660.6	+	14	2110	c.2110C>A	c.(2110-2112)Cac>Aac	p.H704N	RPGRIP1_ENST00000557771.1_Missense_Mutation_p.H666N|RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000307974.4_Missense_Mutation_p.H63N|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.H704N|RPGRIP1_ENST00000553500.1_Intron|RPGRIP1_ENST00000382933.4_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	704					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GCTTGACATACACCAGGCCAT	0.532000													51	127					4.44712e-29	4.47673e-29	1	1	0
UHRF1BP1	54887	broad.mit.edu	37	6	34789448	34789448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34789448C>T	ENST00000192788.5	+	2	234	c.63C>T	c.(61-63)tcC>tcT	p.S21S	UHRF1BP1_ENST00000452449.2_Silent_p.S21S	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	21										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						AGAATCTTTCCCCAGACAAAA	0.443000													5	60					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6511995	6511995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6511995C>T	ENST00000377828.1	+	10	2332	c.2164C>T	c.(2164-2166)Ccc>Tcc	p.P722S	ESPN_ENST00000461727.1_Missense_Mutation_p.P156S|ESPN_ENST00000416731.1_Missense_Mutation_p.P156S|ESPN_ENST00000475228.1_3'UTR	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	722	Pro-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding	p.P722S(1)		NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		AAGCTTGGTTCCCGTGCCGCC	0.672000													3	15					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197403884	197403884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197403884G>A	ENST00000367397.1	+	5	1892	c.1034G>A	c.(1033-1035)aGa>aAa	p.R345K	CRB1_ENST00000544212.1_Missense_Mutation_p.R445K|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.R852K|CRB1_ENST00000535699.1_Missense_Mutation_p.R940K|CRB1_ENST00000367400.3_Missense_Mutation_p.R964K			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	964	EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATATTATTCAGAAGCAATGGG	0.323000													38	87					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140926196	140926196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140926196C>T	ENST00000298296.1	+	1	95	c.95C>T	c.(94-96)tCc>tTc	p.S32F		NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	32										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					TATGCCTTATCCCCAGTGGTG	0.562000													60	38					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48565282	48565282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48565282G>A	ENST00000354276.3	-	14	1557	c.1230C>T	c.(1228-1230)ttC>ttT	p.F410F	PLA2G4C_ENST00000413144.2_Silent_p.F410F|CTD-2265M8.2_ENST00000596552.1_RNA|PLA2G4C_ENST00000596510.1_5'UTR|CTD-2265M8.2_ENST00000601548.1_RNA|CTD-2265M8.2_ENST00000601950.1_RNA|PLA2G4C_ENST00000599921.1_Silent_p.F410F|PLA2G4C_ENST00000599111.1_Silent_p.F420F	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	410	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CACTGAAGTCGAAGGAGAGGA	0.622000													49	104					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170503	58170503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58170503G>A	ENST00000309403.2	-	1	379	c.380C>T	c.(379-381)cCc>cTc	p.P127L		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTAATGTAGGGGTTTGCACAC	0.498000													46	104					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36130237	36130237	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36130237C>T	ENST00000303965.4	-	21	4047	c.3558G>A	c.(3556-3558)acG>acA	p.T1186T		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1186	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TCAACACAGCCGTCACATCTT	0.388000													20	56					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121631514	121631514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121631514G>A	ENST00000515109.1	-	13	1755	c.1499C>T	c.(1498-1500)cCt>cTt	p.P500L	PRDM5_ENST00000428209.2_Silent_p.L529L|PRDM5_ENST00000506065.1_5'UTR|PRDM5_ENST00000264808.3_Silent_p.L560L			Q9NQX1	PRDM5_HUMAN	PR domain containing 5	0					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGCTCATCCAGGCCTCGCTTC	0.473000													17	35					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735888	41735888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41735888C>T	ENST00000352645.4	+	10	1142	c.885C>T	c.(883-885)ttC>ttT	p.F295F	ZC3H7B_ENST00000351589.4_Silent_p.F295F	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	311					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						TACCCGTGTTCCCCGGCGGGA	0.667000													29	101					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21856193	21856193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21856193G>A	ENST00000328843.6	+	65	10493	c.10462G>A	c.(10462-10464)Gaa>Aaa	p.E3488K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E3481K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3488	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AATGTCCACCGAAAATGCCGC	0.493000									Kartagener syndrome				15	27					0	0	1	0	0
SLC22A5	6584	broad.mit.edu	37	5	131729429	131729429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131729429C>T	ENST00000245407.3	+	9	1733	c.1512C>T	c.(1510-1512)atC>atT	p.I504I	SLC22A5_ENST00000435065.2_Silent_p.I528I	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	504					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TGACAGCCATCCTCACCTTGT	0.552000													86	183					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979817	12979817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12979817G>A	ENST00000361079.2	+	4	1092	c.1009G>A	c.(1009-1011)Gag>Aag	p.E337K						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTTCAGCCCTGAGCCCCTCAC	0.582000													10	99					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118764380	118764380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118764380G>A	ENST00000292174.4	+	2	303	c.127G>A	c.(127-129)Ggg>Agg	p.G43R		NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	43					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TGCCACAGAGGGGCCCCTCAT	0.597000													30	102					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38307601	38307601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38307601C>T	ENST00000311856.4	+	1	299	c.250C>T	c.(250-252)Ctc>Ttc	p.L84F	SLC22A13_ENST00000450935.2_Missense_Mutation_p.L43F	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	84						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		AGAGCCCTGCCTCATGTTCCG	0.592000													5	36					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48267435	48267435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48267435G>A	ENST00000225964.5	-	36	2604	c.2486C>T	c.(2485-2487)cCt>cTt	p.P829L		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	829	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	AGCATCACCAGGTTCGCCTTT	0.657000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						29	65					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178936259	178936259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:178936259G>A	ENST00000286063.5	-	1	1223	c.906C>T	c.(904-906)gcC>gcT	p.A302A	PDE11A_ENST00000358450.4_Intron	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	302	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CTACCTGGTAGGCATCAGGAA	0.512000									Primary Pigmented Nodular Adrenocortical Disease, Familial				10	141					0	0	1	0	0
CDK14	5218	broad.mit.edu	37	7	90355918	90355918	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:90355918G>A	ENST00000406263.1	+	2	465	c.23G>A	c.(22-24)gGa>gAa	p.G8E	CDK14_ENST00000496279.1_3'UTR|CDK14_ENST00000436577.2_5'UTR|CDK14_ENST00000380050.3_Missense_Mutation_p.G54E|CDK14_ENST00000265741.3_Missense_Mutation_p.G36E			O94921	CDK14_HUMAN	cyclin-dependent kinase 14	54				Q -> R (in Ref. 3; BAG60284).	cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(12)|ovary(1)|skin(4)	32						AACTGCCAGGGAATGGACTCA	0.408000													8	79					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	114009781	114009781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:114009781C>T	ENST00000375430.4	-	3	243	c.197G>A	c.(196-198)cGg>cAg	p.R66Q	GRTP1-AS1_ENST00000423246.1_RNA|GRTP1-AS1_ENST00000419199.1_RNA|GRTP1_ENST00000375431.4_Missense_Mutation_p.R66Q			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	66						intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GACCCCTTTCCGGACATAGCG	0.657000													3	25					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907641	12907641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12907641C>T	ENST00000317869.6	-	2	727	c.502G>A	c.(502-504)Gga>Aga	p.G168R		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TTGGAAGATCCCCGCTTTCCA	0.478000													102	508					0	0	1	0	0
ZNF567	163081	broad.mit.edu	37	19	37211306	37211306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37211306C>T	ENST00000585696.1	+	3	2817	c.1587C>T	c.(1585-1587)tcC>tcT	p.S529S	ZNF567_ENST00000536254.2_Silent_p.S560S|ZNF567_ENST00000392163.2_Silent_p.S529S|ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000588311.1_Silent_p.S529S|ZNF567_ENST00000360729.4_Silent_p.S529S			Q8N184	ZN567_HUMAN	zinc finger protein 567	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GCCAGAAATCCTATGAATGTC	0.413000													11	114					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97918838	97918838	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97918838C>T	ENST00000534948.1	+	0	3616							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		ATGCAGAGTCCACTTTTAAAT	0.333000													5	52					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915535	119915535	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:119915535G>A	ENST00000331113.4	+	1	1814	c.849G>A	c.(847-849)gaG>gaA	p.E283E		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	283					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CAGACAATGAGGACGTCAGCG	0.537000													17	38					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61941113	61941113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61941113C>T	ENST00000280772.1	-	18	2349	c.2158G>A	c.(2158-2160)Ggg>Agg	p.G720R	ANK3_ENST00000503366.1_Missense_Mutation_p.G703R|ANK3_ENST00000373827.2_Missense_Mutation_p.G714R	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	720					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACATGAGCCCCTTGGTTTACG	0.498000													36	143					0	0	1	0	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95374429	95374429	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:95374429G>A	ENST00000494840.1	-	0	1432					NR_077228.1																						AAGCATTGCAGATCTTTCTCT	0.398000													23	90					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	42080468	42080468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42080468G>A	ENST00000400454.1	-	2	750	c.273C>T	c.(271-273)ttC>ttT	p.F91F		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	91	Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTAAGGTACTGAAGCTTGAAG	0.498000													41	109					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167056312	167056312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167056312G>A	ENST00000375387.4	-	27	5180	c.4840C>T	c.(4840-4842)Cgt>Tgt	p.R1614C	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1613C|SCN9A_ENST00000409672.1_Missense_Mutation_p.R1602C|SCN9A_ENST00000303354.6_Missense_Mutation_p.R1614C			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1613						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CTGGCAAGACGGATCACTCGG	0.428000													47	133					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90179560	90179560	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:90179560T>C	ENST00000370454.4	+	3	1686	c.1431T>C	c.(1429-1431)tgT>tgC	p.C477C	LRRC8C_ENST00000479252.1_Intron|RP11-302M6.4_ENST00000370453.5_Intron	NM_032270.4	NP_115646.2	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	477						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		TGCACCAGTGTTCTGTCAAAA	0.463000													36	86					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13737473	13737473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13737473G>A	ENST00000265104.4	-	66	11447	c.11343C>T	c.(11341-11343)ctC>ctT	p.L3781L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3781	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCACGACAATGAGACTTTCAT	0.453000									Kartagener syndrome				45	119					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537328	55537328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55537328C>T	ENST00000220676.1	+	4	1034	c.886C>T	c.(886-888)Cct>Tct	p.P296S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	296					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCTTTTGTTCCTGAAAAGTA	0.318000													17	55					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153652232	153652232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153652232C>T	ENST00000368680.3	+	1	1120	c.648C>T	c.(646-648)gaC>gaT	p.D216D		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	216					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TTACGGTGGACCACCTGGAGT	0.652000													4	10					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5758549	5758549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5758549C>T	ENST00000317121.3	+	1	869	c.803C>T	c.(802-804)tCa>tTa	p.S268L	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GTAGTGATTTCAGTGACTCAT	0.443000													107	276					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169842736	169842736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169842736C>T	ENST00000263817.6	-	10	1091	c.967G>A	c.(967-969)Gga>Aga	p.G323R		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	323	ABC transmembrane type-1 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GTAAAGAATCCCATCACTATT	0.443000													12	112					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140494159	140494159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:140494159G>A	ENST00000288602.6	-	8	1149	c.1089C>T	c.(1087-1089)tcC>tcT	p.S363S		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	363					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GAGCTGATGAGGATCGGTCTC	0.408000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				33	93					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772551	4772551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:4772551C>T	ENST00000378191.4	+	2	1002	c.621C>T	c.(619-621)tcC>tcT	p.S207S	AJAP1_ENST00000378190.3_Silent_p.S207S	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	207	Thr-rich.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CCACGGTCTCCATCCTACAAA	0.637000													8	21					0	0	1	0	0
OR10W1	81341	broad.mit.edu	37	11	58034458	58034458	+	Silent	SNP	G	G	A	rs146836599		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58034458G>A	ENST00000395079.2	-	1	1274	c.873C>T	c.(871-873)gcC>gcT	p.A291A		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				CTCTCCCTACGGCCCCTTTCA	0.517000													34	82					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20534356	20534356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:20534356C>T	ENST00000377252.3	+	13	2236	c.1395C>T	c.(1393-1395)ctC>ctT	p.L465L	PLXDC2_ENST00000377238.2_3'UTR|PLXDC2_ENST00000377242.3_Silent_p.L416L	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	465						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						TCCTGGTCCTCATTGTAGCCA	0.473000													60	149					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14775702	14775702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:14775702G>A	ENST00000403951.2	-	5	705	c.286C>T	c.(286-288)Cca>Tca	p.P96S	DGKB_ENST00000444700.2_Missense_Mutation_p.P89S|DGKB_ENST00000402815.1_Missense_Mutation_p.P96S|DGKB_ENST00000406247.3_Missense_Mutation_p.P96S|DGKB_ENST00000399322.3_Missense_Mutation_p.P96S|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Missense_Mutation_p.P96S|DGKB_ENST00000407950.1_Missense_Mutation_p.P89S			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	96					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TTTACCATTGGACTAGAATGA	0.348000													4	14					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283671	40283671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40283671C>T	ENST00000325157.6	-	2	332	c.82G>A	c.(82-84)Gac>Aac	p.D28N		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	28	ENTH.							p.D28N(1)|p.D28Y(1)		breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					CCCCAAGGGTCGTTAGAAGTT	0.393000													51	100					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256493	63256493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:63256493C>T	ENST00000323865.3	-	1	1287	c.1054G>A	c.(1054-1056)Ggc>Agc	p.G352S	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	352					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ATGAAGGTGCCCATGATGATG	0.592000													21	156					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96055276	96055276	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96055276C>T	ENST00000356055.3	+	23	5522	c.615_splice	c.e23-1	p.S206_splice	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Silent_p.F1492F|WNK2_ENST00000427277.2_Silent_p.F1455F|WNK2_ENST00000395477.2_Silent_p.F1843F|WNK2_ENST00000297954.4_Silent_p.F1880F			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1879	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CCACCGCCTTCCTGCAGAGGC	0.692000													8	20					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14747004	14747004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14747004C>T	ENST00000380881.4	-	35	6873	c.6058G>A	c.(6058-6060)Gga>Aga	p.G2020R	FREM1_ENST00000380894.1_Missense_Mutation_p.G555R|FREM1_ENST00000380880.3_Missense_Mutation_p.G2019R|FREM1_ENST00000422223.2_Missense_Mutation_p.G2019R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	2019					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TGGAAGAGTCCCTTTAATTCC	0.468000													6	23					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	22005007	22005007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22005007C>T	ENST00000327430.3	-	1	343	c.49G>A	c.(49-51)Gaa>Aaa	p.E17K	SALL2_ENST00000317492.5_Missense_Mutation_p.E17K	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	17							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CTGGGACCTTCGCAGTCCGAG	0.632000													24	45					0	0	1	0	0
DHDH	27294	broad.mit.edu	37	19	49442727	49442727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49442727C>T	ENST00000221403.2	+	4	428	c.388C>T	c.(388-390)Cct>Tct	p.P130S	DHDH_ENST00000522614.1_Missense_Mutation_p.P130S|DHDH_ENST00000523250.1_Intron	NM_014475.3	NP_055290.1	Q9UQ10	DHDH_HUMAN	dihydrodiol dehydrogenase (dimeric)	130					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			central_nervous_system(1)|large_intestine(3)|lung(3)|ovary(1)|soft_tissue(1)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		CCGCTTCTTTCCTGCCTCCGA	0.567000													59	101					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052800	15052800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15052800C>T	ENST00000248072.3	+	1	500	c.500C>T	c.(499-501)tCc>tTc	p.S167F		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TTGAGGCTGTCCTTCTGCACA	0.488000													96	182					0	0	1	0	0
DPPA5	340168	broad.mit.edu	37	6	74063623	74063623	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:74063623C>T	ENST00000370370.3	-	2	314	c.245G>A	c.(244-246)tGg>tAg	p.W82*		NM_001025290.2	NP_001020461.1	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	82	KH; atypical.				multicellular organismal development	cytoplasm	RNA binding			NS(1)|endometrium(1)|lung(5)	7						CTGGAGCATCCACTTGGTCCG	0.627000													7	31					0	0	1	0	0
DPH7	92715	broad.mit.edu	37	9	140468793	140468793	+	Silent	SNP	G	G	A	rs140349182	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140468793G>A	ENST00000277540.2	-	5	664	c.507C>T	c.(505-507)tcC>tcT	p.S169S	DPH7_ENST00000479650.1_5'UTR	NM_138778.2	NP_620133.1			diphthamide biosynthesis 7																		GCTGCCCTGTGGAGTCACTGC	0.567000													9	109					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216737577	216737577	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216737577C>T	ENST00000391890.3	-	7	1315	c.798G>A	c.(796-798)tgG>tgA	p.W266*	ESRRG_ENST00000463665.1_Nonsense_Mutation_p.W220*|ESRRG_ENST00000366937.1_Nonsense_Mutation_p.W294*|ESRRG_ENST00000361395.2_Nonsense_Mutation_p.W259*|ESRRG_ENST00000360012.3_Nonsense_Mutation_p.W259*|ESRRG_ENST00000493603.1_Nonsense_Mutation_p.W259*|ESRRG_ENST00000366938.2_Nonsense_Mutation_p.W259*|ESRRG_ENST00000359162.2_Nonsense_Mutation_p.W259*|ESRRG_ENST00000366940.2_Nonsense_Mutation_p.W259*|ESRRG_ENST00000361525.3_Nonsense_Mutation_p.W259*|ESRRG_ENST00000493748.1_Nonsense_Mutation_p.W259*|ESRRG_ENST00000408911.3_Nonsense_Mutation_p.W282*|ESRRG_ENST00000487276.1_Nonsense_Mutation_p.W259*	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	282					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TATGCTTCGCCCATCCAATGA	0.423000													28	60					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238445	3238445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3238445C>T	ENST00000217939.6	-	5	5435	c.5281G>A	c.(5281-5283)Gag>Aag	p.E1761K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1761						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACTTTTCTCTCTCTCATTACT	0.507000													18	11					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26228957	26228957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26228957C>T	ENST00000335473.7	+	16	3303	c.3053C>T	c.(3052-3054)cCc>cTc	p.P1018L	MYO18B_ENST00000536101.1_Missense_Mutation_p.P1018L|MYO18B_ENST00000407587.2_Missense_Mutation_p.P1018L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1018	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GATCAAAATCCCTCTCAGGTA	0.498000													27	69					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327454	57327454	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57327454C>T	ENST00000326441.9	-	10	2719	c.2356G>A	c.(2356-2358)Gaa>Aaa	p.E786K	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.E662K|PEG3_ENST00000593695.1_Missense_Mutation_p.E660K|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.E786K	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	786					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCTGAGCTTCCACAGAGGCT	0.433000													85	204					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52591936	52591936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:52591936C>T	ENST00000395961.3	-	8	1340	c.1174G>A	c.(1174-1176)Gag>Aag	p.E392K	BCAS1_ENST00000371435.2_Missense_Mutation_p.E392K|BCAS1_ENST00000371440.3_Intron|BCAS1_ENST00000434986.2_Intron	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	392						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			ACATTCTCCTCCGCACCTGTG	0.413000													11	33					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183498122	183498122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183498122C>T	ENST00000367537.3	+	8	934	c.739C>T	c.(739-741)Cct>Tct	p.P247S	SMG7_ENST00000347615.2_Missense_Mutation_p.P218S|SMG7_ENST00000456731.2_Missense_Mutation_p.P176S|SMG7_ENST00000515829.2_Missense_Mutation_p.P218S|SMG7_ENST00000507469.1_Missense_Mutation_p.P218S|SMG7_ENST00000508461.1_Missense_Mutation_p.P176S|SMG7_ENST00000507406.1_3'UTR			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	218					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TGTGAAGTTCCCTTTCCCAGC	0.418000													37	104					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8214429	8214429	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8214429C>T	ENST00000539824.1	+	4	395	c.19_splice	c.e4-1	p.D7_splice	SH3TC1_ENST00000245105.3_Splice_Site_p.D83_splice			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	83							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						CCCCTCCAGACCTGACCCTGC	0.652000													11	15					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42298192	42298192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42298192G>A	ENST00000399518.3	-	4	1007	c.521C>T	c.(520-522)cCg>cTg	p.P174L	PLA2G4E_ENST00000413860.2_Missense_Mutation_p.P145L	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	156					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		ACCCACCTGCGGGTTGAGTGG	0.522000													11	47					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40357727	40357727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40357727C>T	ENST00000221347.6	-	34	15593	c.15586G>A	c.(15586-15588)Gag>Aag	p.E5196K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5196	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAACAGCGCTCGCTGCAGTCT	0.587000													16	38					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138999	126138999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:126138999C>T	ENST00000299308.3	+	9	2988	c.2980C>T	c.(2980-2982)Cat>Tat	p.H994Y	TMEM132B_ENST00000535886.1_Missense_Mutation_p.H506Y	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	994						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAAGACTTTTCATAGTCAACT	0.448000													13	27					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932393	83932393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83932393G>A	ENST00000345382.2	-	4	1695	c.1610C>T	c.(1609-1611)tCc>tTc	p.S537F	BNC1_ENST00000569704.1_Missense_Mutation_p.S530F|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	537					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						GGACTTCCTGGATTTCTTCTT	0.463000													14	145					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113999136	113999136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113999136C>T	ENST00000429538.3	-	7	963	c.769G>A	c.(769-771)Ggc>Agc	p.G257S	AC016683.6_ENST00000451179.1_RNA|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000333145.5_RNA|PAX8_ENST00000348715.5_Missense_Mutation_p.G257S|PAX8_ENST00000263335.7_Missense_Mutation_p.G257S|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000397647.3_Missense_Mutation_p.G257S|PAX8_ENST00000263334.5_Missense_Mutation_p.G257S|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000422956.1_RNA	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	257					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						ACCTGCTCGCCTTTGGTGTGG	0.617000			T	PPARG	follicular thyroid		Thyroid dysgenesis						6	4					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18188342	18188342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18188342C>T	ENST00000600835.1	-	6	836	c.533G>A	c.(532-534)aGc>aAc	p.S178N	IL12RB1_ENST00000593993.1_Missense_Mutation_p.S178N|IL12RB1_ENST00000430026.2_Missense_Mutation_p.S178N|IL12RB1_ENST00000322153.6_Missense_Mutation_p.S178N			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	178	Fibronectin type-III 2.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCATGGGCTGCTGGGTGTCCG	0.597000													8	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179599285	179599285	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179599285C>T	ENST00000589042.1	-	52	15490	c.15266G>A	c.(15265-15267)gGa>gAa	p.G5089E	TTN_ENST00000342992.6_Missense_Mutation_p.G3845E|TTN_ENST00000591111.1_Missense_Mutation_p.G4772E|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4772	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCATTTGTTCCTCTCACTAT	0.363000													30	134					0	0	1	0	0
SAFB2	9667	broad.mit.edu	37	19	5612564	5612564	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5612564G>A	ENST00000252542.4	-	6	885	c.621C>T	c.(619-621)tcC>tcT	p.S207S		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GCTCCAAAAGGGATTCTTCAA	0.338000													6	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179635143	179635143	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179635143C>T	ENST00000589042.1	-	35	8600	c.8376G>A	c.(8374-8376)gtG>gtA	p.V2792V	TTN_ENST00000342992.6_Silent_p.V2792V|TTN_ENST00000360870.5_Silent_p.V2792V|TTN_ENST00000591111.1_Silent_p.V2792V|TTN_ENST00000342175.6_Silent_p.V2746V|TTN_ENST00000359218.5_Silent_p.V2746V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V2746V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2530							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTACTCTCCACGTGCAGTC	0.438000													23	77					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179554594	179554594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179554594C>T	ENST00000589042.1	-	122	32016	c.31792G>A	c.(31792-31794)Gaa>Aaa	p.E10598K	TTN_ENST00000342992.6_Missense_Mutation_p.E9354K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10281K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10281	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTTTCTTCAGGGACAGGT	0.403000													75	218					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117553124	117553124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117553124C>T	ENST00000374045.4	-	4	477	c.364G>A	c.(364-366)Gaa>Aaa	p.E122K	TNFSF15_ENST00000374044.1_Missense_Mutation_p.E45K	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	122					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						AGGCCTAGTTCATGTTCCCAG	0.448000													21	66					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222729	140222729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140222729C>T	ENST00000531613.1	+	1	1823	c.1823C>T	c.(1822-1824)tCg>tTg	p.S608L	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.S608L|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1												p.S608L(4)		NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGGCTTTCGTATGAGCTG	0.682000													20	29					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117079486	117079486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117079486C>T	ENST00000262820.3	-	2	1060	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K	KLHL13_ENST00000371878.1_5'UTR|KLHL13_ENST00000371882.1_5'UTR|KLHL13_ENST00000541812.1_Missense_Mutation_p.E35K|KLHL13_ENST00000545703.1_Missense_Mutation_p.E9K|KLHL13_ENST00000469946.1_5'UTR|KLHL13_ENST00000371876.1_5'UTR|KLHL13_ENST00000539496.1_Missense_Mutation_p.E54K|KLHL13_ENST00000540167.1_Missense_Mutation_p.E35K	NM_033495.3	NP_277030.2	Q9P2N7	KLH13_HUMAN	kelch-like family member 13	51					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AGGCCCATTTCGCTGCCTCCA	0.433000													14	23					0	0	1	0	0
AGPAT9	84803	broad.mit.edu	37	4	84519293	84519293	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:84519293C>T	ENST00000395226.2	+	11	1304	c.1086C>T	c.(1084-1086)atC>atT	p.I362I	AGPAT9_ENST00000264409.4_Silent_p.I362I	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	362					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				GCTGGGCCATCGTCTGTGACG	0.448000													31	76					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212180634	212180634	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:212180634G>A	ENST00000366994.3	-	6	818	c.714C>T	c.(712-714)ttC>ttT	p.F238F	INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000366992.3_Silent_p.F238F|INTS7_ENST00000440600.2_Silent_p.F189F|INTS7_ENST00000366993.3_Silent_p.F238F	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	238					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CAAGCAGAGTGAAAGTGTGCA	0.398000													22	42					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36150108	36150108	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36150108G>A	ENST00000303965.4	-	17	3408	c.2919C>T	c.(2917-2919)atC>atT	p.I973I		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	973	PH 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGGGTAAGTAGATCTCAAAGA	0.328000													15	42					0	0	1	0	0
COQ3	51805	broad.mit.edu	37	6	99819417	99819417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:99819417G>A	ENST00000254759.3	-	6	800	c.776C>T	c.(775-777)tCc>tTc	p.S259F	COQ3_ENST00000369242.1_Missense_Mutation_p.S31F|COQ3_ENST00000369240.1_Missense_Mutation_p.S31F	NM_017421.3	NP_059117.3	Q9NZJ6	COQ3_HUMAN	coenzyme Q3 methyltransferase	259					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			cervix(1)|lung(5)|upper_aerodigestive_tract(2)	8		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		CAAGGCATAGGAAAGTTGTGT	0.338000													23	30					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155198856	155198856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155198856G>A	ENST00000460012.1	-	23	5226	c.4869C>T	c.(4867-4869)caC>caT	p.H1623H	PLCH1_ENST00000414191.1_Silent_p.H1623H|PLCH1_ENST00000340059.7_Silent_p.H1661H|PLCH1_ENST00000334686.6_Silent_p.H1623H|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000494598.1_Intron			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1661					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CGTGGCCATAGTGAAGAGCCG	0.507000													24	28					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106456510	106456510	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106456510G>A	ENST00000520492.1	+	0	374				ZFPM2_ENST00000407775.2_Missense_Mutation_p.D68N			Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2						blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TTTTCCAGGTGATGATGAAGG	0.463000													6	16					0	0	1	0	0
SLC25A38	54977	broad.mit.edu	37	3	39433010	39433010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39433010C>T	ENST00000273158.4	+	4	732	c.355C>T	c.(355-357)Cat>Tat	p.H119Y		NM_017875.2	NP_060345.2	Q96DW6	S2538_HUMAN	solute carrier family 25, member 38	119					erythrocyte differentiation|heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CTTGCGAGGCCATCCCCCAAC	0.532000													28	341					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254708	51254708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:51254708G>A	ENST00000404971.1	-	2	2043	c.704C>T	c.(703-705)tCc>tTc	p.S235F	NRXN1_ENST00000405581.1_Missense_Mutation_p.S235F|NRXN1_ENST00000402717.3_Missense_Mutation_p.S235F|NRXN1_ENST00000401669.2_Missense_Mutation_p.S235F|NRXN1_ENST00000406316.2_Missense_Mutation_p.S235F|NRXN1_ENST00000405472.3_Missense_Mutation_p.S235F|NRXN1_ENST00000406859.3_Missense_Mutation_p.S235F	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	235	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GTCCACCACGGAGCACACACC	0.726000													15	19					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166959017	166959017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:166959017G>A	ENST00000367872.4	+	2	420	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	MAEL_ENST00000367870.2_Intron	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	59					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						GAAATGGCTCGAGAATGGAGG	0.527000													11	32					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43927322	43927322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43927322C>T	ENST00000282406.4	+	8	1335	c.1225C>T	c.(1225-1227)Cct>Tct	p.P409S		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	409						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CACCCCAAGCCCTATTTTGAC	0.423000													35	94					0	0	1	0	0
RDH8	50700	broad.mit.edu	37	19	10132058	10132058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10132058C>T	ENST00000591589.1	+	5	913	c.724C>T	c.(724-726)Cca>Tca	p.P242S	RDH8_ENST00000171214.1_Missense_Mutation_p.P222S			Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	222					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			endometrium(3)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|prostate(1)	21			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	CCTCTATCTCCCAGCCTCCAG	0.587000													33	103					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85971439	85971439	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85971439G>A	ENST00000372117.3	+	14	1624	c.1521G>A	c.(1519-1521)gtG>gtA	p.V507V	CDHR1_ENST00000332904.3_Silent_p.V507V|CDHR1_ENST00000440770.2_Silent_p.V211V	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	507	Cadherin 5.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						GGGGCGAAGTGAAATATTCCA	0.572000													64	145					0	0	1	0	0
ACTG2	72	broad.mit.edu	37	2	74141990	74141990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74141990C>T	ENST00000409624.1	+	8	1440	c.797C>T	c.(796-798)tCc>tTc	p.S266F	ACTG2_ENST00000345517.3_Missense_Mutation_p.S266F|ACTG2_ENST00000409731.3_Missense_Mutation_p.S223F			P63267	ACTH_HUMAN	actin, gamma 2, smooth muscle, enteric	266					muscle contraction	cytoskeleton|cytosol	ATP binding			large_intestine(3)|lung(14)|skin(1)	18						TTCCAGCCTTCCTTTATTGGT	0.577000													20	61					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26089961	26089961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26089961G>A	ENST00000313735.6	-	22	2896	c.2663C>T	c.(2662-2664)tCc>tTc	p.S888F		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	888	FAD-binding FR-type.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CACCCGCAGGGACGGGAACTC	0.572000													5	7					0	0	1	0	0
FFAR1	2864	broad.mit.edu	37	19	35842810	35842810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35842810G>A	ENST00000246553.2	+	1	366	c.356G>A	c.(355-357)aGg>aAg	p.R119K		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	119					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GCCTTCCGGAGGCCGTGCTAT	0.672000													22	51					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422713	26422713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26422713G>A	ENST00000335473.7	+	43	7023	c.6773G>A	c.(6772-6774)cGg>cAg	p.R2258Q	MYO18B_ENST00000536101.1_Missense_Mutation_p.R2258Q|MYO18B_ENST00000407587.2_Missense_Mutation_p.R2259Q	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2258						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GAAGGGCTCCGGAGGAAGAGA	0.627000													12	17					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29364623	29364623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29364623C>T	ENST00000383555.2	+	1	208	c.147C>T	c.(145-147)tcC>tcT	p.S49S	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						TTGTCATCTCCGATCCTAGAC	0.458000													23	97					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46782321	46782321	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46782321G>A	ENST00000262738.3	-	19	6716	c.6717C>T	c.(6715-6717)ttC>ttT	p.F2239F		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2239					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGACGATGACGAAGGGCCGCA	0.677000													6	10					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110456078	110456078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110456078G>A	ENST00000378402.5	+	37	4842	c.4738G>A	c.(4738-4740)Gaa>Aaa	p.E1580K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1580	IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AACAGTAAATGAACTAATAAC	0.328000										HNSCC(38;0.096)			49	64					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28909943	28909943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28909943C>T	ENST00000257192.4	+	5	673	c.461C>T	c.(460-462)cCt>cTt	p.P154L		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	154	Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AATGACAACCCTCCAGTGTTT	0.433000													23	98					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648700	62648700	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:62648700G>A	ENST00000337910.5	-	6	1063	c.726C>T	c.(724-726)gtC>gtT	p.V242V	RHOBTB1_ENST00000357917.4_Silent_p.V242V	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	242					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					GAATTTTGATGACCGGTGGAG	0.498000													19	169					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192327	132192327	+	Missense_Mutation	SNP	G	G	A	rs151233036		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:132192327G>A	ENST00000359827.3	-	2	2088	c.1126C>T	c.(1126-1128)Cgg>Tgg	p.R376W	PLXNA4_ENST00000423507.2_Missense_Mutation_p.R376W|PLXNA4_ENST00000321063.4_Missense_Mutation_p.R376W|PLXNA4_ENST00000378539.5_Missense_Mutation_p.R376W			Q9HCM2	PLXA4_HUMAN	plexin A4	376	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCCTCGCCCCGGTAACAAGAC	0.587000													7	87					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236908011	236908011	+	Silent	SNP	C	C	T	rs34785693	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236908011C>T	ENST00000366578.4	+	12	1507	c.1341C>T	c.(1339-1341)ttC>ttT	p.F447F	ACTN2_ENST00000542672.1_Silent_p.F447F|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_5'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	447					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			ACGAGGCGTTCGAGAGCGACC	0.637000													40	21					0	0	1	0	0
TRAV6	6956	broad.mit.edu	37	14	22237162	22237162	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22237162G>A	ENST00000390428.3	+	0	246																											CAAGATCCAGGAAGAGGCCCT	0.453000													28	69					0	0	1	0	0
C4BPB	725	broad.mit.edu	37	1	207262917	207262917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207262917G>A	ENST00000243611.5	+	1	335	c.41G>A	c.(40-42)cGa>cAa	p.R14Q	C4BPB_ENST00000367078.3_Missense_Mutation_p.R14Q|C4BPB_ENST00000367076.3_Missense_Mutation_p.R14Q|C4BPB_ENST00000451804.2_Missense_Mutation_p.R5Q|C4BPB_ENST00000391923.1_Missense_Mutation_p.R14Q	NM_000716.3	NP_000707.1	P20851	C4BPB_HUMAN	complement component 4 binding protein, beta	14					blood coagulation|complement activation, classical pathway|innate immune response	extracellular region				breast(2)|lung(1)|ovary(1)	4						GTTGCGTGGCGAGTTTCTGCT	0.478000													17	43					0	0	1	0	0
ZNF490	57474	broad.mit.edu	37	19	12691844	12691844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12691844G>A	ENST00000311437.6	-	5	1167	c.1045C>T	c.(1045-1047)Ctt>Ttt	p.L349F		NM_020714.2	NP_065765.1	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	18						TGTTTTCGAAGGCTTGAGTGA	0.448000													27	108					0	0	1	0	0
PPP1R1A	5502	broad.mit.edu	37	12	54976578	54976578	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54976578G>A	ENST00000257905.8	-	4	355	c.183_splice	c.e4-1	p.S62_splice	PPP1R1A_ENST00000547431.1_Intron	NM_006741.3	NP_006732.3	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1A	62					glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			lung(2)	2						TGCCAAAGTGGACTGTGAAGG	0.597000													25	43					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8657649	8657649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8657649C>T	ENST00000270328.4	-	12	1851	c.1585G>A	c.(1585-1587)Ggg>Agg	p.G529R	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.G529R			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	529	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GCGCTCACCCCCTTGTCGATG	0.682000													3	14					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98209620	98209620	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:98209620G>A	ENST00000430669.2	-	23	4305	c.3720C>T	c.(3718-3720)ccC>ccT	p.P1240P	PTCH1_ENST00000421141.1_Silent_p.P1155P|PTCH1_ENST00000331920.6_Silent_p.P1306P|PTCH1_ENST00000429896.2_Silent_p.P1155P|PTCH1_ENST00000418258.1_Silent_p.P1155P|PTCH1_ENST00000375274.2_Silent_p.P1305P|PTCH1_ENST00000437951.1_Silent_p.P1240P			Q13635	PTC1_HUMAN	patched 1	1306					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CTTCTCTGGGGGGGTCCCTGC	0.647000													28	63					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32698944	32698944	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32698944C>T	ENST00000380250.3	+	7	1144	c.648C>T	c.(646-648)ccC>ccT	p.P216P		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACCTTGGTCCCAACACTGGCA	0.428000													14	149					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37602816	37602816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37602816C>T	ENST00000328544.3	-	2	1560	c.1027G>A	c.(1027-1029)Ggg>Agg	p.G343R	SSTR3_ENST00000402501.1_Missense_Mutation_p.G343R	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	343					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						TCCGGGGGCCCCACAGTGGGC	0.672000													18	66					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3174071	3174071	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3174071C>T	ENST00000355072.5	+	30	4034	c.3889C>T	c.(3889-3891)Ctg>Ttg	p.L1297L		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1297					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCTAGGATACCTGAAATCCTG	0.408000													11	126					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14799050	14799050	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14799050C>T	ENST00000253697.3	+	13	2565	c.2113C>T	c.(2113-2115)Cga>Tga	p.R705*	C3orf20_ENST00000435614.1_Nonsense_Mutation_p.R583*|C3orf20_ENST00000412910.1_Nonsense_Mutation_p.R583*	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	705						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GTTGGCGCCCCGAGACCCCAG	0.602000													16	40					0	0	1	0	0
APBB2	323	broad.mit.edu	37	4	40946922	40946922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40946922G>A	ENST00000295974.8	-	7	1630	c.1001C>T	c.(1000-1002)tCa>tTa	p.S334L	APBB2_ENST00000506352.1_Missense_Mutation_p.S334L|APBB2_ENST00000508593.1_Missense_Mutation_p.S335L|APBB2_ENST00000513140.1_Missense_Mutation_p.S334L	NM_001166050.1|NM_004307.1	NP_001159522.1|NP_004298.1	Q92870	APBB2_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 2	334					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(3)|skin(2)|urinary_tract(1)	34						AGAACTAAGTGACCCTTTCCT	0.493000													20	87					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181549743	181549743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181549743G>A	ENST00000526775.1	+	6	947	c.782G>A	c.(781-783)gGa>gAa	p.G261E	CACNA1E_ENST00000367570.1_Missense_Mutation_p.G261E|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000360108.3_Missense_Mutation_p.G261E|CACNA1E_ENST00000357570.5_Missense_Mutation_p.G212E|CACNA1E_ENST00000358338.5_Missense_Mutation_p.G212E|CACNA1E_ENST00000367573.2_Missense_Mutation_p.G261E	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	261					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ATTCTAGAAGGATTTGACCCC	0.507000													50	135					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47228866	47228866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47228866G>A	ENST00000391910.3	-	10	1759	c.1309C>T	c.(1309-1311)Ccc>Tcc	p.P437S	STRN4_ENST00000263280.6_Missense_Mutation_p.P430S|STRN4_ENST00000539396.1_Missense_Mutation_p.P311S|STRN4_ENST00000594357.2_5'UTR			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	430						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GTGAACTTGGGGTTCCACGTC	0.602000													14	39					0	0	1	0	0
OR7A17	26333	broad.mit.edu	37	19	14991526	14991526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14991526G>A	ENST00000327462.2	-	1	738	c.642C>T	c.(640-642)atC>atT	p.I214I		NM_030901.1	NP_112163.1	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A, member 17	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12	Ovarian(108;0.203)					AAGAGCAAAGGATCCCCACAA	0.488000													44	124					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202114	140202114	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140202114G>A	ENST00000529859.1	+	1	754	c.754G>A	c.(754-756)Gaa>Aaa	p.E252K	PCDHA5_ENST00000529619.1_Missense_Mutation_p.E252K|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.E252K|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATTGTTGGAAAATGCACC	0.363000													25	104					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189065004	189065004	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189065004G>A	ENST00000332517.3	+	4	888	c.748G>A	c.(748-750)Gcc>Acc	p.A250T	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	250					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGTGAGAGGAGCCCTGGAAAG	0.478000													69	193					0	0	1	0	0
WBSCR16	81554	broad.mit.edu	37	7	74470049	74470049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:74470049G>A	ENST00000503250.2	-	9	1259	c.1190C>T	c.(1189-1191)tCc>tTc	p.S397F	WBSCR16_ENST00000329959.4_Missense_Mutation_p.S397F			Q96I51	WBS16_HUMAN	Williams-Beuren syndrome chromosome region 16	397										kidney(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						TCGGATGCGGGAAACCTGGAT	0.537000													26	67					0	0	1	0	0
ARGFX	503582	broad.mit.edu	37	3	121304974	121304974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121304974C>T	ENST00000334384.3	+	4	485	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	159						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		GCCCACCTCCCCCAGAACATC	0.493000													52	85					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248486965	248486965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248486965C>T	ENST00000317965.2	-	1	934	c.906G>A	c.(904-906)atG>atA	p.M302I		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M302I(1)		breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTAAGATTTTCATTAATGCTC	0.403000													25	60					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	184003362	184003362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184003362C>T	ENST00000402825.3	+	10	1599	c.1599C>T	c.(1597-1599)acC>acT	p.T533T	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000359140.4_Silent_p.T386T|ECE2_ENST00000404464.3_Silent_p.T415T|ECE2_ENST00000357474.5_Silent_p.T461T	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	533	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCTGGAGACCCTCTATGGCA	0.512000													10	79					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10906962	10906962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10906962C>T	ENST00000298232.7	-	23	1912	c.1545G>A	c.(1543-1545)gtG>gtA	p.V515V	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.V495V|TPTE_ENST00000361285.4_Silent_p.V533V	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	533	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAAGTATCTCCACGGCAAAAT	0.353000													7	82					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104075163	104075163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104075163C>T	ENST00000374874.3	+	6	1159	c.720C>T	c.(718-720)ttC>ttT	p.F240F	LPPR1_ENST00000395056.2_Silent_p.F240F	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		240						integral to membrane	catalytic activity										GCACAGCCTTCCTGACAGGCC	0.547000													28	111					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106431506	106431506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106431506G>A	ENST00000407775.2	+	2	425	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	ZFPM2_ENST00000520492.1_5'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	59					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAGCTGCGAAGAAGTGGAATA	0.358000													24	90					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38813452	38813452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38813452G>A	ENST00000359357.3	+	34	4551	c.4297G>A	c.(4297-4299)Gga>Aga	p.G1433R	DNAH8_ENST00000441566.1_Missense_Mutation_p.G1433R|DNAH8_ENST00000449981.2_Missense_Mutation_p.G1650R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGCATTTAAGGGAAAAGGAGA	0.418000													17	126					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7289621	7289621	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7289621C>T	ENST00000537408.1	+	6	1699	c.1161C>T	c.(1159-1161)acC>acT	p.T387T	CLSTN3_ENST00000266546.6_Silent_p.T375T			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	375					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						ACCACTTCACCCTGTCCTTCT	0.587000													28	47					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9197355	9197355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:9197355G>A	ENST00000382496.5	-	10	1658	c.993C>T	c.(991-993)ttC>ttT	p.F331F		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	331	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						AGGGCCCAGAGAAGGCCTGCG	0.602000													41	92					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126208158	126208158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126208158C>T	ENST00000290868.2	-	17	1722	c.1669G>A	c.(1669-1671)Gag>Aag	p.E557K	UROC1_ENST00000383579.3_Missense_Mutation_p.E617K	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	557					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		TTGGAGGTCTCCCTAAAGGGG	0.498000													38	142					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72462204	72462204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72462204C>T	ENST00000309731.7	-	2	131	c.118G>A	c.(118-120)Gag>Aag	p.E40K		NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	40						integral to membrane				cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						TCCGGGGGCTCCTCAACTCTG	0.507000													91	91					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113833	94113833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94113833G>A	ENST00000243673.2	-	4	925	c.754C>T	c.(754-756)Ctc>Ttc	p.L252F	GPR83_ENST00000539203.2_Missense_Mutation_p.L210F	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	252						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATGATGAGGAGGGGCAGGATG	0.567000													13	39					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43433789	43433789	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43433789C>T	ENST00000446844.3	-	0	603				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCTGGAGTCTCAGGATCACAG	0.527000													119	295					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131671830	131671830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:131671830C>T	ENST00000368648.3	-	8	739	c.667G>A	c.(667-669)Ggc>Agc	p.G223S	EBF3_ENST00000355311.5_Missense_Mutation_p.G223S	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	223					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AGCACGTGGCCGTCCACGTTG	0.527000													12	36					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10914373	10914373	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10914373C>T	ENST00000298232.7	-	20	1659	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.G411E|TPTE_ENST00000361285.4_Missense_Mutation_p.G449E	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	449	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CGAACATTTTCCTAATGAAAT	0.318000													6	55					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33589863	33589863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33589863G>A	ENST00000262873.7	+	42	6007	c.5915G>A	c.(5914-5916)cGg>cAg	p.R1972Q		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1930						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CTGCGGGCACGGACCCGGGAC	0.647000											OREG0025884	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	41					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77406945	77406945	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77406945G>A	ENST00000560626.2	-	7	5269	c.4794C>T	c.(4792-4794)ctC>ctT	p.L1598L	PEAK1_ENST00000312493.4_Silent_p.L1598L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1598	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TCTCATAGATGAGGATGCCTG	0.542000													32	87					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104440363	104440363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:104440363G>A	ENST00000372582.1	+	3	1045	c.289G>A	c.(289-291)Gag>Aag	p.E97K	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E97K	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	97	Ig-like C2-type 1.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GATGAGCAAAGAGGAAGATTC	0.448000													35	24					0	0	1	0	0
GLYATL2	219970	broad.mit.edu	37	11	58604639	58604639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58604639C>T	ENST00000287275.1	-	5	715	c.325G>A	c.(325-327)Ggc>Agc	p.G109S	GLYATL2_ENST00000533636.1_5'UTR|GLYATL2_ENST00000532258.1_Missense_Mutation_p.G109S	NM_145016.3	NP_659453.3	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	109						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TCATCCAAGCCCTCTTGGCAA	0.393000													51	131					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66944318	66944318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66944318G>A	ENST00000299752.4	-	15	2205	c.2012C>T	c.(2011-2013)cCc>cTc	p.P671L	CDH16_ENST00000570262.1_Missense_Mutation_p.P591L|CDH16_ENST00000565796.1_Intron|CDH16_ENST00000568632.1_Missense_Mutation_p.P574L|CDH16_ENST00000394055.3_Missense_Mutation_p.P649L	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	671	Ectodomain G.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTATTGGGAGGGCACAGGGGC	0.632000													28	81					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	40998146	40998146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40998146C>T	ENST00000253799.3	+	1	1530	c.1503C>T	c.(1501-1503)ctC>ctT	p.L501L	AOC2_ENST00000452774.2_Silent_p.L501L	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	501					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		AGGAGGGCCTCCTCTTTGGGA	0.567000													32	56					0	0	1	0	0
CEP63	80254	broad.mit.edu	37	3	134256003	134256003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134256003C>T	ENST00000337090.3	+	6	621	c.448C>T	c.(448-450)Cgt>Tgt	p.R150C	CEP63_ENST00000354446.3_Missense_Mutation_p.R150C|CEP63_ENST00000332047.5_Missense_Mutation_p.R150C|CEP63_ENST00000606977.1_Missense_Mutation_p.R150C|CEP63_ENST00000383229.3_Missense_Mutation_p.R150C|CEP63_ENST00000513612.2_Missense_Mutation_p.R150C			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	150					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TCAGGAATTCCGTCAGAAATC	0.458000													19	84					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127648455	127648455	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127648455C>T	ENST00000508053.1	-	43	5724	c.4750G>A	c.(4750-4752)Gga>Aga	p.G1584R	FBN2_ENST00000262464.4_Missense_Mutation_p.G1584R			P35556	FBN2_HUMAN	fibrillin 2	1584	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCTCGAGGTCCAAACTTCAGG	0.537000													30	326					0	0	1	0	0
HSPB8	26353	broad.mit.edu	37	12	119631578	119631578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119631578C>T	ENST00000281938.2	+	3	1177	c.506C>T	c.(505-507)cCc>cTc	p.P169L	HSPB8_ENST00000542496.1_3'UTR	NM_014365.2	NP_055180.1	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	169					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	14	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ATCGAAGCTCCCCAGGTCCCT	0.517000													36	81					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45923856	45923856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45923856G>A	ENST00000348697.2	+	4	598	c.451G>A	c.(451-453)Gga>Aga	p.G151R	FBLN1_ENST00000402984.3_Missense_Mutation_p.G189R|FBLN1_ENST00000327858.6_Missense_Mutation_p.G151R|FBLN1_ENST00000340923.5_Missense_Mutation_p.G151R|FBLN1_ENST00000442170.2_Missense_Mutation_p.G151R|FBLN1_ENST00000262722.7_Missense_Mutation_p.G151R			P23142	FBLN1_HUMAN	fibulin 1	151					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCAGGAGACCGGAGATTTGGA	0.572000													22	87					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031883	32031883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:32031883C>T	ENST00000360311.4	+	2	1861	c.1312C>T	c.(1312-1314)Cgt>Tgt	p.R438C		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						TTTTAGACGTCGTTCATATCT	0.378000													18	68					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23619259	23619259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23619259G>A	ENST00000261584.4	-	12	3428	c.3276C>T	c.(3274-3276)ctC>ctT	p.L1092L	CTD-2196E14.3_ENST00000561764.1_RNA	NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	1092	Interaction with RAD51 and BRCA2.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		TAATCACAATGAGCTGAAACA	0.483000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					14	56					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114120263	114120263	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114120263C>T	ENST00000357077.4	+	4	435	c.382C>T	c.(382-384)Cag>Tag	p.Q128*	ANK2_ENST00000264366.6_Nonsense_Mutation_p.Q128*|ANK2_ENST00000506722.1_Nonsense_Mutation_p.Q107*|ANK2_ENST00000394537.3_Nonsense_Mutation_p.Q128*	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	128					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGCACAGTCTCAGGTATTCCA	0.358000													19	52					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711531	192711531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:192711531C>T	ENST00000304141.4	-	1	450	c.121G>A	c.(121-123)Ggg>Agg	p.G41R	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	41						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCTGTGTTCCCTAGGTTCAGG	0.612000													19	76					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129909563	129909563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129909563C>T	ENST00000222481.4	+	3	263	c.208C>T	c.(208-210)Ccc>Tcc	p.P70S		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	70					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					CGTCCGAGTTCCCTTCGTCAA	0.498000													17	98					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206480313	206480313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206480313C>T	ENST00000406610.2	+	23	3601	c.3394C>T	c.(3394-3396)Ctc>Ttc	p.L1132F	PARD3B_ENST00000351153.1_Missense_Mutation_p.L1063F|PARD3B_ENST00000349953.3_Missense_Mutation_p.L1031F|PARD3B_ENST00000358768.2_Missense_Mutation_p.L1070F|PARD3B_ENST00000488622.1_3'UTR	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	1132					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CCCCACAGAGCTCAGGGTGGC	0.617000													30	106					0	0	1	0	0
NLGN1	22871	broad.mit.edu	37	3	173322869	173322869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:173322869C>T	ENST00000457714.1	+	3	910	c.481C>T	c.(481-483)Ccg>Tcg	p.P161S	NLGN1_ENST00000401917.3_Missense_Mutation_p.P161S|NLGN1_ENST00000361589.4_Missense_Mutation_p.P161S|NLGN1_ENST00000545397.1_Missense_Mutation_p.P161S	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	161					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity	p.P161T(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TATATATGTCCCGACTGAGGA	0.338000													8	127					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138400170	138400170	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:138400170G>A	ENST00000409968.1	+	21	4090	c.3912G>A	c.(3910-3912)tgG>tgA	p.W1304*	THSD7B_ENST00000272643.3_Nonsense_Mutation_p.W1307*|THSD7B_ENST00000413152.2_Nonsense_Mutation_p.W1276*|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCTACAGCTGGGTCCTTGGCA	0.488000													33	76					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454751	84454751	+	Missense_Mutation	SNP	G	G	A	rs146746846		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:84454751G>A	ENST00000377084.2	-	1	1777	c.892C>T	c.(892-894)Cat>Tat	p.H298Y		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	298						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GGTGTGGCATGATCCTCTTGC	0.562000													16	47					0	0	1	0	0
TACR1	6869	broad.mit.edu	37	2	75347872	75347872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:75347872G>A	ENST00000305249.4	-	2	1177	c.412C>T	c.(412-414)Ctc>Ttc	p.L138F	TACR1_ENST00000497764.1_5'UTR|TACR1_ENST00000409848.3_Missense_Mutation_p.L138F	NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1	138					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	CGGGGCTGGAGGGGATGTATG	0.517000													17	45					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27390186	27390186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:27390186G>A	ENST00000379214.4	-	18	2527	c.2084C>T	c.(2083-2085)cCa>cTa	p.P695L	LGR4_ENST00000389858.4_Missense_Mutation_p.P671L	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	695						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						TGTAGGAAATGGCAAACAAAG	0.428000													20	84					0	0	1	0	0
CLEC10A	10462	broad.mit.edu	37	17	6979059	6979059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6979059C>T	ENST00000576617.1	-	7	854	c.585G>A	c.(583-585)agG>agA	p.R195R	CLEC10A_ENST00000416562.2_Silent_p.R195R|CLEC10A_ENST00000571664.1_Silent_p.R198R|CLEC10A_ENST00000254868.4_Silent_p.R222R			Q8IUN9	CLC10_HUMAN	C-type lectin domain family 10, member A	222	C-type lectin.				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						CCTGCTCCTCCCTGGAGTTGA	0.537000													28	37					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1437209	1437209	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1437209G>A	ENST00000345913.4	+	4	270		c.e4-1		TPO_ENST00000337415.3_Splice_Site|TPO_ENST00000382269.3_Splice_Site|TPO_ENST00000497517.2_Intron|TPO_ENST00000346956.3_Splice_Site|TPO_ENST00000349624.3_Splice_Site|TPO_ENST00000382201.3_Splice_Site|TPO_ENST00000329066.4_Splice_Site|TPO_ENST00000382198.1_Splice_Site|TPO_ENST00000539820.1_Splice_Site	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase						cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ATGTGCCATAGAAACCTCAAG	0.363000													10	79					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690487	33690487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33690487G>A	ENST00000394566.1	-	4	612	c.340C>T	c.(340-342)Cct>Tct	p.P114S	SLFN11_ENST00000308377.4_Missense_Mutation_p.P114S	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	114						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCAGGGAAAGGGCCACTGCTC	0.458000													11	56					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583862	88583862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88583862G>A	ENST00000339673.6	+	6	1031	c.932G>A	c.(931-933)aGa>aAa	p.R311K	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.R295K|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	311					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CAACCCAGGAGAGACAGCAAG	0.517000													8	76					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24918476	24918476	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24918476G>A	ENST00000347898.3	+	12	1867	c.1245G>A	c.(1243-1245)aaG>aaA	p.K415K	SLC5A11_ENST00000569071.1_Silent_p.K259K|SLC5A11_ENST00000545376.1_Silent_p.K345K|SLC5A11_ENST00000565769.1_Silent_p.K351K|SLC5A11_ENST00000449109.2_Silent_p.K259K|SLC5A11_ENST00000539472.1_Silent_p.K351K|SLC5A11_ENST00000424767.2_Silent_p.K380K|SLC5A11_ENST00000568579.1_Silent_p.K345K|SLC5A11_ENST00000567758.1_Silent_p.K380K	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	415					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		CATCTGAGAAGGAGCTCATGA	0.602000													25	125					0	0	1	0	0
SLC22A17	51310	broad.mit.edu	37	14	23817804	23817804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23817804G>A	ENST00000354772.3	-	5	1106	c.603C>T	c.(601-603)ttC>ttT	p.F201F	SLC22A17_ENST00000474057.1_Intron|SLC22A17_ENST00000397260.3_Silent_p.F90F|SLC22A17_ENST00000397267.1_Silent_p.F201F|SLC22A17_ENST00000206544.8_Silent_p.F201F	NM_016609.3	NP_057693.3	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17	201					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CCAGGAACAGGAAGTGCCCTC	0.597000													30	124					0	0	1	0	0
AOC1	26	broad.mit.edu	37	7	150554705	150554705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150554705C>T	ENST00000493429.1	+	4	1731	c.1147C>T	c.(1147-1149)Cat>Tat	p.H383Y	AOC1_ENST00000467291.1_Missense_Mutation_p.H383Y|AOC1_ENST00000416793.2_Missense_Mutation_p.H383Y|AOC1_ENST00000360937.4_Missense_Mutation_p.H383Y					amine oxidase, copper containing 1																		CAGCGTCACTCATGAGTTAGC	0.617000													36	112					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32525063	32525063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32525063C>T	ENST00000286827.3	-	20	3728	c.3257G>A	c.(3256-3258)gGa>gAa	p.G1086E	TIAM1_ENST00000541036.1_Missense_Mutation_p.G1026E	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1086	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CGTTAAATTTCCAAAAAGCAC	0.333000													15	46					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73964163	73964163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73964163G>A	ENST00000373468.1	-	3	880	c.229C>T	c.(229-231)Ccg>Tcg	p.P77S	KIAA2022_ENST00000055682.5_Missense_Mutation_p.P77S			Q5QGS0	K2022_HUMAN	KIAA2022	77					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GGAGAGGGCGGGCTCTGCATA	0.537000													31	21					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43038186	43038186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43038186G>A	ENST00000267890.6	-	15	3650	c.3542C>T	c.(3541-3543)tCg>tTg	p.S1181L		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1181	Ser-rich.				cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		ATGTGGGGACGAACTCCTCTG	0.592000													26	69					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46306722	46306722	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46306722G>A	ENST00000357422.2	+	4	616	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	CCR3_ENST00000395942.2_Missense_Mutation_p.E25K|CCR3_ENST00000545097.1_Missense_Mutation_p.E46K|CCR3_ENST00000541018.1_Missense_Mutation_p.E25K|CCR3_ENST00000395940.2_Missense_Mutation_p.E25K			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	25					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CCTGCTCTGTGAAAAAGCTGA	0.502000													17	41					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301398	11301398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11301398G>A	ENST00000397056.1	+	3	866	c.675G>A	c.(673-675)gaG>gaA	p.E225E	HRH1_ENST00000431010.2_Silent_p.E225E|HRH1_ENST00000438284.2_Silent_p.E225E	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	225					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	AGCACCGGGAGCTCATCAATA	0.542000													32	71					0	0	1	0	0
MCOLN2	255231	broad.mit.edu	37	1	85397184	85397184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85397184G>A	ENST00000370608.3	-	12	1470	c.1403C>T	c.(1402-1404)aCc>aTc	p.T468I	MCOLN2_ENST00000284027.5_Missense_Mutation_p.T440I	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	468						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TTGGGCAAAGGTTGCAAACAT	0.388000													6	107					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25701497	25701497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25701497G>A	ENST00000377961.2	+	11	933	c.765G>A	c.(763-765)gtG>gtA	p.V255V	SCGN_ENST00000334979.6_3'UTR	NM_006998.3	NP_008929.2	O76038	SEGN_HUMAN	secretagogin, EF-hand calcium binding protein	255	EF-hand 6.					extracellular region|transport vesicle membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						ACTGCGACGTGAACAAGGATG	0.488000													27	94					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90897934	90897934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90897934C>T	ENST00000354377.3	+	2	228	c.42C>T	c.(40-42)caC>caT	p.H14H	ZNF774_ENST00000379090.5_Silent_p.H14H|ZNF774_ENST00000558115.1_Intron	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	14	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TACCTGGACACTGCTTAGAGA	0.458000													8	26					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169388371	169388371	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169388371C>T	ENST00000545005.1	-	5	1602	c.1095G>A	c.(1093-1095)gaG>gaA	p.E365E	CCDC181_ENST00000367805.3_Silent_p.E365E|CCDC181_ENST00000491570.1_5'UTR|CCDC181_ENST00000367806.3_Silent_p.E365E					coiled-coil domain containing 181																		TTTTTTCTTTCTCTTCTTCTA	0.323000													5	58					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7572486	7572486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:7572486G>A	ENST00000399429.3	-	2	161	c.21C>T	c.(19-21)gtC>gtT	p.V7V		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	7					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGAGATAGAAGACAAAATATC	0.348000													46	94					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39112006	39112006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39112006G>A	ENST00000379907.4	+	18	2103	c.1976G>A	c.(1975-1977)gGa>gAa	p.G659E	ADAM32_ENST00000437682.2_Missense_Mutation_p.G560E|ADAM32_ENST00000519315.1_Missense_Mutation_p.G553E	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	659					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.G658V(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CGTTCCAAAGGATTTTCCATA	0.343000													7	9					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5841957	5841957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5841957C>T	ENST00000317037.2	+	1	414	c.392C>T	c.(391-393)cCc>cTc	p.P131L	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCTGCTACCCCTTACGCTAT	0.552000													21	87					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70007780	70007780	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70007780C>T	ENST00000355303.5	+	18	2138	c.1833C>T	c.(1831-1833)ttC>ttT	p.F611F	ANO1_ENST00000398543.2_Silent_p.F465F|ANO1_ENST00000538023.1_Silent_p.F611F|ANO1_ENST00000530676.1_Silent_p.F465F|ANO1_ENST00000531349.1_Silent_p.F320F|ANO1_ENST00000316296.5_Silent_p.F553F	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	611					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TCAAGGCTTTCCTGCTGAAGT	0.537000													25	142					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126219633	126219633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126219633G>A	ENST00000290868.2	-	11	1103	c.1050C>T	c.(1048-1050)ttC>ttT	p.F350F	UROC1_ENST00000383579.3_Silent_p.F410F	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	350					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		AGCCGCCATTGAACGGGTTGT	0.617000													37	79					0	0	1	0	0
OR51F1	256892	broad.mit.edu	37	11	4790452	4790452	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4790452G>A	ENST00000380383.1	-	1	716	c.717C>T	c.(715-717)tcC>tcT	p.S239S	MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Silent_p.S232S|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	232						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		ATTCTTCAGGGGAGGCAATTC	0.458000													54	108					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25284986	25284986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25284986C>T	ENST00000218548.6	+	21	3305	c.2972C>T	c.(2971-2973)tCc>tTc	p.S991F	ATP12A_ENST00000381946.3_Missense_Mutation_p.S985F	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	985					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CTGATCCTCTCCTATGGCCTC	0.498000													26	41					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20915648	20915648	+	Missense_Mutation	SNP	C	C	T	rs140821931		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20915648C>T	ENST00000375071.3	+	1	208	c.26C>T	c.(25-27)aCc>aTc	p.T9I	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	9					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	CCTGCCTGCACCCTGAAGCCT	0.657000													13	74					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17029467	17029467	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17029467C>T	ENST00000492551.1	-	0	898					NR_026567.1																						GCTGGAAAGCCCTGGGGAGGC	0.577000													6	36					0	0	1	0	0
EEF1A2	1917	broad.mit.edu	37	20	62126344	62126344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62126344C>T	ENST00000217182.3	-	4	600	c.435G>A	c.(433-435)gtG>gtA	p.V145V	EEF1A2_ENST00000298049.7_Silent_p.V145V	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	145						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			TGAGCTGCTTCACACCCAGCG	0.622000													31	93					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205896725	205896725	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205896725G>A	ENST00000367135.3	-	10	1223	c.1110C>T	c.(1108-1110)atC>atT	p.I370I	SLC26A9_ENST00000367134.2_Silent_p.I370I|SLC26A9_ENST00000340781.4_Silent_p.I370I	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	370						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGCCGAGAGCGATCATCTCCT	0.552000													10	30					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118969873	118969873	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:118969873G>A	ENST00000515256.1	+	3	602	c.430G>A	c.(430-432)Gag>Aag	p.E144K				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	144						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						TGTCTCCTGGGAGACAGAGGA	0.468000													35	67					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161753803	161753803	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161753803C>T	ENST00000367942.3	+	4	338	c.271C>T	c.(271-273)Cag>Tag	p.Q91*		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	91	Transcription activation.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GGCAGAACCTCAGCCACTTTC	0.398000													42	164					0	0	1	0	0
ZNF596	169270	broad.mit.edu	37	8	192971	192971	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:192971C>T	ENST00000398612.1	+	3	480	c.97C>T	c.(97-99)Caa>Taa	p.Q33*	ZNF596_ENST00000320552.2_Nonsense_Mutation_p.Q33*|ZNF596_ENST00000522866.1_3'UTR|ZNF596_ENST00000308811.4_Nonsense_Mutation_p.Q33*	NM_001042415.1|NM_001042416.1	NP_001035880.1|NP_001035881.1	Q8TC21	ZN596_HUMAN	zinc finger protein 596	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(5)	14		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		AAAGCTGTTTCAAGATGTGAT	0.393000													31	46					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39050237	39050237	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:39050237G>T	ENST00000295373.6	-	17	3315	c.3189C>A	c.(3187-3189)ccC>ccA	p.P1063P		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1063							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TCACATCCACGGGCAGAGAGG	0.463000													24	76					1.10923e-09	1.11347e-09	1	1	0
DDX31	64794	broad.mit.edu	37	9	135487526	135487526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135487526G>A	ENST00000372159.3	-	19	2408	c.2257C>T	c.(2257-2259)Ccc>Tcc	p.P753S	DDX31_ENST00000372153.1_Missense_Mutation_p.P680S|DDX31_ENST00000438527.3_Missense_Mutation_p.P624S	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	753						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		AGATTCCTGGGGGCATCTCTT	0.552000													32	131					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12316366	12316366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12316366C>T	ENST00000256186.2	+	3	1679	c.1388C>T	c.(1387-1389)cCt>cTt	p.P463L		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	463	Poly-Pro.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcctcctcctcctcctcct	0.577000													13	14					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212149950	212149950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:212149950G>A	ENST00000366994.3	-	12	1686	c.1582C>T	c.(1582-1584)Cgt>Tgt	p.R528C	INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000366992.3_Missense_Mutation_p.R528C|INTS7_ENST00000440600.2_Missense_Mutation_p.R479C|INTS7_ENST00000366993.3_Missense_Mutation_p.R528C	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	528					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CTGGCAATACGGTATACAGTC	0.408000													43	91					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57931689	57931689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57931689C>T	ENST00000574161.1	+	10	1184	c.1065C>T	c.(1063-1065)caC>caT	p.H355H	GCOM1_ENST00000380561.2_Silent_p.H324H|GCOM1_ENST00000572390.1_Silent_p.H355H|GCOM1_ENST00000380560.2_Silent_p.H286H|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Silent_p.H355H|GCOM1_ENST00000587652.1_Silent_p.H355H|GCOM1_ENST00000396180.1_Silent_p.H324H|MYZAP_ENST00000267853.5_Silent_p.H355H|GCOM1_ENST00000380568.3_Silent_p.H355H|MYZAP_ENST00000380565.4_Silent_p.H355H	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		355					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GGATCAGACACCTAGATGACA	0.498000													8	47					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54570741	54570741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54570741G>A	ENST00000251636.5	-	15	2673	c.2525C>T	c.(2524-2526)cCt>cTt	p.P842L	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	842							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GATTTTATGAGGATTCATGTA	0.358000													54	154					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042300	74042300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74042300G>A	ENST00000409561.1	+	3	1071	c.950G>A	c.(949-951)aGc>aAc	p.S317N		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	317										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TCCTTCAGTAGCAGAAATACC	0.468000													17	53					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169145710	169145710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169145710G>A	ENST00000256935.8	+	22	2262	c.2182G>A	c.(2182-2184)Gag>Aag	p.E728K	DOCK2_ENST00000540750.1_5'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.E220K	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	728					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGCAGAGGGGAGCAATGTGA	0.383000													31	60					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95347184	95347184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95347184C>T	ENST00000371483.4	+	4	1008	c.952C>T	c.(952-954)Ctc>Ttc	p.L318F	FFAR4_ENST00000371481.4_Missense_Mutation_p.L302F|FFAR4_ENST00000604414.1_Intron	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		CTGGCCGTCCCTCTTCTTCTG	0.488000													60	255					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76395507	76395507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76395507G>A	ENST00000357063.3	+	15	3818	c.2558G>A	c.(2557-2559)aGa>aAa	p.R853K	LMO7_ENST00000377534.3_Missense_Mutation_p.R853K|LMO7_ENST00000321797.8_Missense_Mutation_p.R568K|LMO7_ENST00000526202.1_Missense_Mutation_p.R418K|LMO7_ENST00000341547.4_Missense_Mutation_p.R519K|LMO7_ENST00000465261.2_Missense_Mutation_p.R568K			Q8WWI1	LMO7_HUMAN	LIM domain 7	853						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TTTGCAAAAAGAGAGGACCGT	0.443000													36	90					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102441875	102441875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102441875C>T	ENST00000413150.2	+	5	456	c.401C>T	c.(400-402)tCc>tTc	p.S134F	MAP4K4_ENST00000302217.5_Missense_Mutation_p.S134F|MAP4K4_ENST00000347699.4_Missense_Mutation_p.S134F|MAP4K4_ENST00000425019.1_Missense_Mutation_p.S134F|MAP4K4_ENST00000350878.4_Missense_Mutation_p.S114F|MAP4K4_ENST00000456652.1_Missense_Mutation_p.S134F|MAP4K4_ENST00000350198.4_Missense_Mutation_p.S134F|MAP4K4_ENST00000324219.4_Missense_Mutation_p.S134F	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	134	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GCTTACATCTCCAGAGAAATC	0.478000													9	34					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238249231	238249231	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238249231C>T	ENST00000295550.4	-	38	8780	c.8328G>A	c.(8326-8328)agG>agA	p.R2776R	COL6A3_ENST00000353578.4_Silent_p.R2570R|COL6A3_ENST00000409809.1_Silent_p.R2570R|COL6A3_ENST00000472056.1_Silent_p.R2169R|COL6A3_ENST00000346358.4_Silent_p.R2576R|COL6A3_ENST00000347401.3_Silent_p.R2575R	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2776	Nonhelical region.|VWFA 12.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGTTCACCTTCCTGCCAATGC	0.562000													34	77					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47401285	47401285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47401285G>A	ENST00000310638.4	-	5	576	c.545C>T	c.(544-546)cCt>cTt	p.P182L	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Missense_Mutation_p.P182L|CYP4A11_ENST00000371905.1_Missense_Mutation_p.P182L|CYP4A11_ENST00000457840.2_Missense_Mutation_p.P78L	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	182					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	GACCTCCAGAGGGGAATCCTG	0.542000													12	59					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33624341	33624341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33624341C>T	ENST00000504830.1	-	14	2473	c.2138G>A	c.(2137-2139)gGa>gAa	p.G713E	ADAMTS12_ENST00000352040.3_Intron|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	713	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						ATTACCAGATCCTTCCTTCTG	0.443000										HNSCC(64;0.19)			34	115					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151671950	151671950	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:151671950G>A	ENST00000402676.2	+	4	2664	c.2424G>A	c.(2422-2424)aaG>aaA	p.K808K	AKAP12_ENST00000359755.5_Silent_p.K703K|AKAP12_ENST00000354675.6_Silent_p.K710K|AKAP12_ENST00000253332.1_Silent_p.K808K	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	808	AKAP 3.				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TCTCAATCAAGAAGTTTATTC	0.498000													37	68					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29346369	29346369	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:29346369G>C	ENST00000558402.1	+	5	881	c.282G>C	c.(280-282)gaG>gaC	p.E94D	APBA2_ENST00000411764.1_Missense_Mutation_p.E94D|APBA2_ENST00000558330.1_Missense_Mutation_p.E94D|APBA2_ENST00000558259.1_Missense_Mutation_p.E94D|APBA2_ENST00000561069.1_Missense_Mutation_p.E94D			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	94	Poly-Glu.				nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CTGAGGAGGAGGAGGGCATCA	0.607000													24	124					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637121	248637121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248637121G>A	ENST00000359594.2	+	1	495	c.470G>A	c.(469-471)gGa>gAa	p.G157E		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGGTTTTGGGAATGGTTGAT	0.522000													10	33					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21215530	21215530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21215530G>A	ENST00000574002.1	-	10	1275	c.793C>T	c.(793-795)Cct>Tct	p.P265S	ZP2_ENST00000219593.4_Missense_Mutation_p.P265S|ZP2_ENST00000574091.1_Missense_Mutation_p.P265S|AF001550.7_ENST00000572747.1_RNA			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	265					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		CAGGTCACAGGATCTAGAAGG	0.468000													21	75					0	0	1	0	0
AZGP1P1	646282	broad.mit.edu	37	7	99580912	99580912	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99580912G>A	ENST00000425474.1	+	0	233					NR_036679.1																						TGGGACCATGGAGACATGCGG	0.542000													15	24					0	0	1	0	0
GJA9	81025	broad.mit.edu	37	1	39341152	39341152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:39341152C>T	ENST00000454994.2	-	2	895	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	MYCBP_ENST00000489803.1_5'UTR|RP5-864K19.4_ENST00000456813.1_RNA|RP5-864K19.4_ENST00000443161.1_RNA|RP5-864K19.4_ENST00000433671.2_RNA|GJA9_ENST00000360786.3_Missense_Mutation_p.E207K|GJA9_ENST00000357771.3_Missense_Mutation_p.E207K			P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	207					cell communication	connexon complex|integral to membrane				breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			ATTGTCTTTTCTGTTGGTCTT	0.338000													29	57					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128186115	128186115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128186115G>A	ENST00000453608.2	+	8	1152	c.1144G>A	c.(1144-1146)Gag>Aag	p.E382K	PROC_ENST00000409048.1_Missense_Mutation_p.E361K|PROC_ENST00000422777.3_Missense_Mutation_p.E327K|PROC_ENST00000234071.3_Missense_Mutation_p.E327K			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	327	Peptidase S1.				blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	CGGCCTTGCAGAGCGCGAGCT	0.657000													45	136					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62658388	62658388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62658388C>T	ENST00000535781.1	+	15	2073	c.1962C>T	c.(1960-1962)gcC>gcT	p.A654A	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	694					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TCAGGGCAGCCCAAGATCTGT	0.572000													27	51					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719138	140719138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140719138G>A	ENST00000394576.2	+	1	600	c.600G>A	c.(598-600)ctG>ctA	p.L200L	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGCTCTCTGGACCGCGAGG	0.587000													29	61					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27465619	27465619	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27465619C>T	ENST00000264705.4	+	41	6516	c.6354C>T	c.(6352-6354)ttC>ttT	p.F2118F	CAD_ENST00000403525.1_Silent_p.F2055F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	2118	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TGCGGGCCTTCGTGGCCTCCC	0.657000													24	45					0	0	1	0	0
NSMF	26012	broad.mit.edu	37	9	140344095	140344095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140344095G>A	ENST00000371475.3	-	15	1682	c.1451C>T	c.(1450-1452)cCt>cTt	p.P484L	NSMF_ENST00000371482.1_Missense_Mutation_p.P148L|NSMF_ENST00000437259.1_Missense_Mutation_p.P461L|NSMF_ENST00000339554.3_Missense_Mutation_p.P281L|NSMF_ENST00000371474.3_Missense_Mutation_p.P459L|NSMF_ENST00000371472.2_Missense_Mutation_p.P482L|NSMF_ENST00000541195.1_Missense_Mutation_p.P281L|NSMF_ENST00000371473.3_Missense_Mutation_p.P454L|NSMF_ENST00000265663.7_Missense_Mutation_p.P482L|NSMF_ENST00000392812.4_Missense_Mutation_p.P461L|NSMF_ENST00000484316.1_5'UTR	NM_001130969.1	NP_001124441.1			NMDA receptor synaptonuclear signaling and neuronal migration factor																		GACCCTATAAGGAGTCATGAG	0.637000													6	13					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76980987	76980987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76980987C>T	ENST00000315938.4	-	7	669	c.419G>A	c.(418-420)aGg>aAg	p.R140K	GDPD4_ENST00000376217.2_Missense_Mutation_p.R140K	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	140					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						ATGTGTCATCCTGTATCTTCT	0.333000													9	31					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41754721	41754721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41754721G>A	ENST00000301178.4	+	14	1897	c.1707G>A	c.(1705-1707)atG>atA	p.M569I	AXL_ENST00000359092.3_Missense_Mutation_p.M560I|AXL_ENST00000593513.1_Missense_Mutation_p.M301I	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	569	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						TGAAGACGATGAAGAGTGAGT	0.547000													15	39					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37731005	37731005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37731005G>A	ENST00000539465.1	+	9	1356	c.763G>A	c.(763-765)Gac>Aac	p.D255N	FRMPD1_ENST00000377765.3_Missense_Mutation_p.D255N|FRMPD1_ENST00000541302.1_Missense_Mutation_p.D124N|FRMPD1_ENST00000536622.1_Missense_Mutation_p.D77N|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	255	FERM.					cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GGAGTCACATGACTACCGCTG	0.502000													17	56					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62798036	62798036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:62798036C>T	ENST00000280377.5	+	22	2885	c.2827C>T	c.(2827-2829)Cct>Tct	p.P943S	USP15_ENST00000353364.3_Missense_Mutation_p.P914S|USP15_ENST00000393654.3_Missense_Mutation_p.P918S	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	943					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TGGCTTTTTTCCTCTTGACCG	0.378000													42	171					0	0	1	0	0
BCAR3	8412	broad.mit.edu	37	1	94140254	94140254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94140254G>A	ENST00000370244.1	-	4	521	c.233C>T	c.(232-234)tCc>tTc	p.S78F	BCAR3_ENST00000260502.6_Missense_Mutation_p.S78F|BCAR3_ENST00000370243.1_Missense_Mutation_p.S78F	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	78					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CTGCCGTGGGGATTTGGAGTG	0.552000													10	37					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8234014	8234014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8234014G>A	ENST00000520004.1	-	3	2169	c.1905C>T	c.(1903-1905)tgC>tgT	p.C635C	SGK223_ENST00000330777.4_Silent_p.C635C			Q86YV5	SG223_HUMAN		635							ATP binding|non-membrane spanning protein tyrosine kinase activity										CCTCTATCCGGCACTGACGAC	0.602000													17	53					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89949527	89949527	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89949527G>A	ENST00000405460.2	+	20	4232	c.4136G>A	c.(4135-4137)gGa>gAa	p.G1379E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1379					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GACGGTAATGGAAGCATCTAC	0.408000													4	19					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55953808	55953808	+	Missense_Mutation	SNP	G	G	A	rs11540507		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55953808G>A	ENST00000263923.4	-	27	3923	c.3628C>T	c.(3628-3630)Ccc>Tcc	p.P1210S	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1210					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TGGAATTTGGGGTCACATACT	0.507000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			17	58					0	0	1	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077314	19077314	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:19077314G>A	ENST00000329773.2	-	2	723	c.636C>T	c.(634-636)ggC>ggT	p.G212G		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	212					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						GACCCCTGGAGCCACAGAGGA	0.547000													26	43					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42485934	42485934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42485934G>A	ENST00000545399.1	-	10	1434	c.1281C>T	c.(1279-1281)atC>atT	p.I427I	ATP1A3_ENST00000302102.5_Silent_p.I414I|ATP1A3_ENST00000602133.1_Silent_p.I384I|ATP1A3_ENST00000543770.1_Silent_p.I425I	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	414					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						AGAGCCCAGCGATGTGAGACA	0.622000													20	52					0	0	1	0	0
ACP6	51205	broad.mit.edu	37	1	147122011	147122011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:147122011G>A	ENST00000369238.5	-	8	1359	c.912C>T	c.(910-912)ttC>ttT	p.F304F	ACP6_ENST00000460583.1_5'UTR	NM_016361.3	NP_057445.4	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic	304					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(4)|prostate(1)	16	all_hematologic(923;0.0276)					GGATGTGGAGGAATGGGCCTA	0.522000													23	45					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23397352	23397352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23397352G>A	ENST00000324366.8	-	3	521	c.298C>T	c.(298-300)Cgc>Tgc	p.R100C	PRMT5_ENST00000397440.4_Missense_Mutation_p.R83C|PRMT5_ENST00000553641.1_5'UTR|PRMT5_ENST00000553897.1_Intron|PRMT5_ENST00000538452.1_5'UTR|PRMT5_ENST00000216350.8_Intron|PRMT5_ENST00000397441.2_Missense_Mutation_p.R83C	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	100					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GAGTTCCTGCGAATCTTCTCC	0.498000													7	102					0	0	1	0	0
PPCS	79717	broad.mit.edu	37	1	42925347	42925347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42925347C>T	ENST00000372561.3	+	3	693	c.686C>T	c.(685-687)tCc>tTc	p.S229F	PPCS_ENST00000455780.1_Missense_Mutation_p.S56F|PPCS_ENST00000372556.3_3'UTR|PPCS_ENST00000472013.1_3'UTR|PPCS_ENST00000372562.1_Missense_Mutation_p.S56F	NM_024664.2	NP_078940.2	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase	229					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|skin(3)	12	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TTTATAATTTCCTTTAAGTTG	0.388000													11	125					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194118751	194118751	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:194118751G>A	ENST00000401815.1	-	1	332	c.261C>T	c.(259-261)tcC>tcT	p.S87S	GP5_ENST00000323007.3_Silent_p.S87S			P40197	GPV_HUMAN	glycoprotein V (platelet)	87					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GGGCAACGGCGGAAATGTGGC	0.587000													41	62					0	0	1	0	0
C10orf62	414157	broad.mit.edu	37	10	99350007	99350007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:99350007C>T	ENST00000370640.3	+	1	558	c.353C>T	c.(352-354)tCc>tTc	p.S118F	PI4K2A_ENST00000370649.3_Intron|HOGA1_ENST00000370647.4_Intron|PI4K2A_ENST00000555577.1_Intron|HOGA1_ENST00000370646.4_Intron	NM_001009997.2	NP_001009997.2	Q5T681	CJ062_HUMAN	chromosome 10 open reading frame 62	118							protein binding			endometrium(2)|kidney(1)|lung(1)	4		Colorectal(252;0.162)		Epithelial(162;9.58e-11)|all cancers(201;8.62e-09)		AAAGCCCCATCCACTGATGAG	0.627000													26	48					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106066431	106066431	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106066431C>T	ENST00000577108.1	-	0	115				IGHE_ENST00000576077.1_RNA																							AGACACCGCTCGCTGGACGGT	0.607000													43	128					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713226	70713226	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70713226C>T	ENST00000530196.1	-	0	1292					NR_003951.1																						AGGTGGTCTTCATAAAATCAG	0.413000													60	145					0	0	1	0	0
CHRNA3	1136	broad.mit.edu	37	15	78911186	78911186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78911186G>A	ENST00000326828.5	-	2	538	c.154C>T	c.(154-156)Cct>Tct	p.P52S	CHRNA3_ENST00000348639.3_Missense_Mutation_p.P52S	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	52					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TTGGCTACAGGCCGGATGATC	0.572000											OREG0023334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	109					0	0	1	0	0
PAFAH1B2	5049	broad.mit.edu	37	11	117038270	117038270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117038270C>T	ENST00000527958.1	+	6	704	c.545C>T	c.(544-546)tCg>tTg	p.S182L	PAFAH1B2_ENST00000529887.2_Intron|PAFAH1B2_ENST00000530272.1_Intron|PAFAH1B2_ENST00000419197.2_Intron|PAFAH1B2_ENST00000526888.1_Intron	NM_002572.3	NP_002563.1	P68402	PA1B2_HUMAN	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	182					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity			kidney(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;1.68e-05)|Epithelial(105;0.000162)|all cancers(92;0.00111)		TTTGTGCACTCGGACGGTGCC	0.537000			T	IGH@	MLCLS								8	55					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196964899	196964899	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196964899G>A	ENST00000367414.5	+	5	788	c.732G>A	c.(730-732)aaG>aaA	p.K244K	CFHR5_ENST00000256785.4_Silent_p.K220K	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	220	Sushi 4.				complement activation, alternative pathway	extracellular region		p.K220N(1)		NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						GTGAAGTTAAGGAGATAAGAA	0.338000													24	63					0	0	1	0	0
FAM19A2	338811	broad.mit.edu	37	12	62104181	62104181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:62104181C>T	ENST00000551449.1	-	3	302	c.124G>A	c.(124-126)Gag>Aag	p.E42K	FAM19A2_ENST00000550003.1_3'UTR|FAM19A2_ENST00000551619.1_3'UTR|FAM19A2_ENST00000416284.3_3'UTR			Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	0						cytoplasm				endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	15			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		CTTGATTTCTCCTGGGTTAAT	0.333000													51	133					0	0	1	0	0
IRAK3	11213	broad.mit.edu	37	12	66641931	66641931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:66641931G>A	ENST00000261233.4	+	12	2192	c.1771G>A	c.(1771-1773)Gaa>Aaa	p.E591K	IRAK3_ENST00000457197.2_Missense_Mutation_p.E530K	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	591					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		GGATGAATATGAACAGTACAA	0.418000													26	54					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837421	82837421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82837421G>A	ENST00000265077.3	+	8	9164	c.8599G>A	c.(8599-8601)Gaa>Aaa	p.E2867K	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.E1880K|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2867	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTCTTTTAAGGAAATTCATGT	0.458000													32	108					0	0	1	0	0
SLC29A1	2030	broad.mit.edu	37	6	44198553	44198553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44198553C>T	ENST00000393841.1	+	9	1184	c.693C>T	c.(691-693)ttC>ttT	p.F231F	SLC29A1_ENST00000371755.3_Silent_p.F231F|SLC29A1_ENST00000371740.5_Silent_p.F231F|SLC29A1_ENST00000472176.1_3'UTR|SLC29A1_ENST00000393844.1_Silent_p.F231F|SLC29A1_ENST00000313248.7_Silent_p.F310F|SLC29A1_ENST00000371731.1_Silent_p.F231F|SLC29A1_ENST00000371724.1_Silent_p.F231F|SLC29A1_ENST00000371713.1_Silent_p.F231F|SLC29A1_ENST00000427851.2_Silent_p.F231F|SLC29A1_ENST00000371708.1_Silent_p.F231F	NM_001078177.1	NP_001071645.1	Q99808	S29A1_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 1	231					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	17	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	GATAGGAATTCTACCGCTACT	0.547000													29	82					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179577424	179577424	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179577424C>T	ENST00000589042.1	-	94	27552	c.27328_splice	c.e94+1	p.A9110_splice	TTN_ENST00000342992.6_Splice_Site_p.A7866_splice|TTN_ENST00000591111.1_Splice_Site_p.A8793_splice|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8793	Ig-like 74.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGACAAACCTTTTATGTAG	0.338000													32	82					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5486048	5486048	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:5486048C>T	ENST00000345221.3	-	2	944	c.390G>A	c.(388-390)caG>caA	p.Q130Q	NLRP1_ENST00000262467.5_Silent_p.Q130Q|NLRP1_ENST00000577119.1_Silent_p.Q130Q|NLRP1_ENST00000572272.1_Silent_p.Q130Q|NLRP1_ENST00000269280.4_Silent_p.Q130Q|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000354411.3_Silent_p.Q130Q	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	130					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				TCTCTGAGCCCTGGGTGCACC	0.632000													12	10					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256254	15256254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15256254C>T	ENST00000378116.4	-	8	1339	c.1333G>A	c.(1333-1335)Gat>Aat	p.D445N	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	445						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GTGAGGTTATCAAAGGAGATC	0.498000													23	51					0	0	1	0	0
KHK	3795	broad.mit.edu	37	2	27322557	27322557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27322557G>A	ENST00000260599.6	+	8	1349	c.836G>A	c.(835-837)aGa>aAa	p.R279K	CGREF1_ENST00000452318.2_3'UTR|CGREF1_ENST00000402550.1_3'UTR|KHK_ENST00000490823.1_3'UTR|KHK_ENST00000260598.5_Missense_Mutation_p.R279K	NM_000221.2	NP_000212.1	P50053	KHK_HUMAN	ketohexokinase (fructokinase)	279					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAGCACTGAGATTCGGGTGC	0.617000													15	32					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141025	143141025	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143141025C>T	ENST00000332690.1	+	1	480	c.480C>T	c.(478-480)ttC>ttT	p.F160F	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	160					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					TTCTATTTTTCATAGGCAACC	0.453000													55	170					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3312936	3312936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3312936G>A	ENST00000252032.9	-	11	1121	c.1054C>T	c.(1054-1056)Cct>Tct	p.P352S	C20orf194_ENST00000453730.2_Missense_Mutation_p.P91S	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	352										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						CCCAAGTAAGGAACATGAGTA	0.383000													9	17					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31386389	31386389	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31386389C>T	ENST00000328111.2	+	15	1935	c.1614C>T	c.(1612-1614)cgC>cgT	p.R538R	DNMT3B_ENST00000443239.3_Silent_p.R476R|DNMT3B_ENST00000201963.3_Silent_p.R530R|DNMT3B_ENST00000456297.2_Silent_p.R442R|DNMT3B_ENST00000348286.2_Silent_p.R518R|DNMT3B_ENST00000344505.4_Silent_p.R518R|DNMT3B_ENST00000353855.2_Silent_p.R518R|DNMT3B_ENST00000375623.4_3'UTR	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	538	ADD.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCCTGCGGCGCCGGAAGGACT	0.637000													26	43					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46375450	46375450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46375450G>A	ENST00000302177.2	+	2	384	c.187G>A	c.(187-189)Gga>Aga	p.G63R		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	63					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		ACTGCCCTCAGGACCCCTGGC	0.706000													20	53					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110029765	110029765	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110029765C>T	ENST00000369870.3	+	4	450	c.435C>T	c.(433-435)tcC>tcT	p.S145S		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	145										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CGAAAACCTCCTCCAGGGAGA	0.622000													3	18					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70949081	70949081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70949081G>A	ENST00000334414.6	-	20	5046	c.5002C>T	c.(5002-5004)Cct>Tct	p.P1668S	PTPRB_ENST00000550358.1_Missense_Mutation_p.P1580S|PTPRB_ENST00000261266.5_Missense_Mutation_p.P1450S|PTPRB_ENST00000451516.2_Missense_Mutation_p.P1360S|PTPRB_ENST00000538708.1_Missense_Mutation_p.P1360S|PTPRB_ENST00000550857.1_Missense_Mutation_p.P1360S	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1450					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGGGGTGGAGGAGGGGGGCCT	0.483000													4	14					0	0	1	0	0
DNAJB6	10049	broad.mit.edu	37	7	157160088	157160088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157160088C>T	ENST00000262177.4	+	5	462	c.257C>T	c.(256-258)cCa>cTa	p.P86L	DNAJB6_ENST00000452797.2_Missense_Mutation_p.P37L|DNAJB6_ENST00000443280.1_Missense_Mutation_p.P86L|DNAJB6_ENST00000429029.2_Missense_Mutation_p.P86L	NM_058246.3	NP_490647.1	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	86	Gly/Phe-rich.|Interaction with HSP70.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			central_nervous_system(1)|lung(1)|ovary(2)|stomach(1)	5	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		TTTGACAGTCCATTTGAATTT	0.363000													19	177					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145095248	145095248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145095248C>T	ENST00000377470.3	+	2	752	c.650C>T	c.(649-651)cCc>cTc	p.P217L	SPATC1_ENST00000447830.2_Missense_Mutation_p.P217L	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	217										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGGCCAACCCCATGAGCAAC	0.682000													14	62					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940669	113940669	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113940669G>A	ENST00000245796.6	+	2	831	c.636G>A	c.(634-636)ggG>ggA	p.G212G	PSD4_ENST00000441564.2_Silent_p.G212G	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	212					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AAGACTCAGGGGAAGACAGCA	0.637000													8	35					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	6925673	6925673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6925673C>T	ENST00000409757.4	+	2	681	c.557C>T	c.(556-558)tCc>tTc	p.S186F	TBC1D14_ENST00000448507.1_Missense_Mutation_p.S186F	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	186						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						ACGAGCAGCTCCAGTGCCATT	0.552000													11	28					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	39966858	39966858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39966858C>T	ENST00000336649.4	+	1	101	c.101C>T	c.(100-102)tCc>tTc	p.S34F	CACNA1I_ENST00000407673.1_Missense_Mutation_p.S34F|CACNA1I_ENST00000404898.1_Missense_Mutation_p.S34F|CACNA1I_ENST00000402142.3_Missense_Mutation_p.S34F|CACNA1I_ENST00000401624.1_Missense_Mutation_p.S34F|CACNA1I_ENST00000400164.3_Missense_Mutation_p.S34F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	34					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCCCCATCCTCCCCGCCAGGC	0.682000													17	27					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61962829	61962829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61962829G>A	ENST00000280772.1	-	12	1514	c.1323C>T	c.(1321-1323)gcC>gcT	p.A441A	ANK3_ENST00000503366.1_Silent_p.A424A|ANK3_ENST00000373827.2_Silent_p.A435A	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	441					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCCCCATGAAGGCAGCAACAT	0.443000													29	51					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169656228	169656228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169656228G>A	ENST00000428432.2	+	9	1664	c.1275G>A	c.(1273-1275)atG>atA	p.M425I	SAMD7_ENST00000335556.3_Missense_Mutation_p.M425I	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	425										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GTGATACAATGAACATTTTTT	0.388000													21	40					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158262543	158262543	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158262543T>C	ENST00000368170.3	+	4	1047	c.768T>C	c.(766-768)ccT>ccC	p.P256P		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	256	Ig-like.				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					ATATTCTTCCTAATGCTGATG	0.527000													44	95					0	0	1	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31813035	31813035	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31813035G>A	ENST00000334067.3	+	1	439	c.390G>A	c.(388-390)agG>agA	p.R130R		NM_181623.1	NP_853654.1	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	130						intermediate filament				kidney(1)|large_intestine(3)|lung(6)|skin(1)	11						TTTCATCCAGGAATTTCCAGG	0.453000													44	119					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230687	147230687	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:147230687G>A	ENST00000271348.2	-	2	821	c.660C>T	c.(658-660)ctC>ctT	p.L220L	GJA5_ENST00000369237.1_Silent_p.L220L	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	220					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CCAGGCTAAGGAGGAGGGACA	0.562000													19	24					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3601144	3601144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:3601144C>T	ENST00000302006.3	+	4	1485	c.1433C>T	c.(1432-1434)cCg>cTg	p.P478L		NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	478						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GCAGCCCTCCCGTCCGCCTGA	0.587000													9	59					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37289169	37289169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37289169G>A	ENST00000233099.5	-	11	1704	c.1609C>T	c.(1609-1611)Ctt>Ttt	p.L537F	HEATR5B_ENST00000354531.2_Missense_Mutation_p.L537F	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	537							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				GTTCGTAAAAGATCTTCAGCA	0.343000													24	59					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155774885	155774885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155774885G>A	ENST00000437809.1	-	11	1622	c.1500C>T	c.(1498-1500)ccC>ccT	p.P500P	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Silent_p.P500P|GON4L_ENST00000368331.1_Silent_p.P500P|GON4L_ENST00000271883.5_Silent_p.P500P			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	500					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CATCTTTCAGGGGCATCTTAG	0.483000													31	94					0	0	1	0	0
TMEM203	94107	broad.mit.edu	37	9	140099732	140099732	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140099732G>A	ENST00000343666.5	-	1	358	c.135C>T	c.(133-135)tcC>tcT	p.S45S	TMEM203_ENST00000537254.1_Silent_p.S45S	NM_053045.1	NP_444273.1	Q969S6	TM203_HUMAN	transmembrane protein 203	45						integral to membrane				central_nervous_system(1)|kidney(1)	2	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CGTTCCACCAGGAGAGGCCCG	0.622000													5	22					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215802311	215802311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215802311G>A	ENST00000272895.7	-	51	7684	c.7465C>T	c.(7465-7467)Cac>Tac	p.H2489Y	ABCA12_ENST00000389661.4_Missense_Mutation_p.H2171Y|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2489	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTCTTCAAGTGAACTTTGACA	0.368000													21	64					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100157211	100157211	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:100157211G>A	ENST00000370575.4	-	6	564	c.516C>T	c.(514-516)gcC>gcT	p.A172A	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	172							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						GAGGGTCAATGGCTAATGCCA	0.587000													21	55					0	0	1	0	0
OR4F15	390649	broad.mit.edu	37	15	102358521	102358521	+	Silent	SNP	C	C	T	rs143311907		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:102358521C>T	ENST00000332238.4	+	1	156	c.132C>T	c.(130-132)gtC>gtT	p.V44V		NM_001001674.1	NP_001001674.1	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F, member 15	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(10)	19	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			GAAACCTTGTCATTGTATTCA	0.413000													24	384					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402395	248402395	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248402395C>T	ENST00000306687.1	+	1	165	c.165C>T	c.(163-165)ctC>ctT	p.L55L		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGAAACAGCTCCACACCCCCA	0.483000													77	184					0	0	1	0	0
SLC26A6	65010	broad.mit.edu	37	3	48669750	48669750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48669750G>A	ENST00000358747.6	-	4	700	c.450C>T	c.(448-450)atC>atT	p.I150I	SLC26A6_ENST00000420764.2_Silent_p.I171I|SLC26A6_ENST00000455886.2_Intron|SLC26A6_ENST00000337000.8_Intron|SLC26A6_ENST00000383733.3_Silent_p.I171I|SLC26A6_ENST00000395550.2_Silent_p.I171I|SLC26A6_ENST00000482282.1_5'UTR	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CTGTCTCATTGATCATGGAGT	0.592000													26	27					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86940712	86940712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86940712C>T	ENST00000441037.2	+	17	2447	c.2352C>T	c.(2350-2352)ctC>ctT	p.L784L	AGBL1_ENST00000389298.3_Silent_p.L515L|AGBL1_ENST00000421325.2_Silent_p.L784L	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	784					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TGGCTAGGCTCTTGAGGGAAA	0.517000													32	138					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60754776	60754776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60754776C>T	ENST00000303375.5	+	12	2383	c.1981C>T	c.(1981-1983)Ccc>Tcc	p.P661S		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	661					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GGGGCCAGATCCCACGCCCAG	0.672000													7	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179666989	179666989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179666989G>A	ENST00000589042.1	-	3	395	c.171C>T	c.(169-171)tcC>tcT	p.S57S	TTN_ENST00000342992.6_Silent_p.S57S|TTN_ENST00000360870.5_Silent_p.S57S|TTN_ENST00000591111.1_Silent_p.S57S|TTN_ENST00000342175.6_Silent_p.S57S|TTN_ENST00000359218.5_Silent_p.S57S|TTN_ENST00000460472.2_Silent_p.S57S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	57	Ig-like 1.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCGCTAAAGGAGATCTGCA	0.527000													23	61					0	0	1	0	0
PPP1R12A	4659	broad.mit.edu	37	12	80182511	80182511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80182511G>A	ENST00000450142.2	-	21	2985	c.2719C>T	c.(2719-2721)Cgc>Tgc	p.R907C	PPP1R12A_ENST00000261207.5_Missense_Mutation_p.R907C|PPP1R12A_ENST00000550107.1_Missense_Mutation_p.R851C|PPP1R12A_ENST00000437004.2_Missense_Mutation_p.R907C|PPP1R12A_ENST00000546369.1_Missense_Mutation_p.R820C	NM_002480.2	NP_002471.1	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory subunit 12A	907						contractile fiber	protein binding|signal transducer activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|liver(1)|lung(4)|ovary(2)|skin(1)	29						GATCCAGAGCGACCCAGCAAG	0.353000													7	23					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187416366	187416366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:187416366G>A	ENST00000358241.1	-	2	1026	c.598C>T	c.(598-600)Cgc>Tgc	p.R200C		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	200					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding	p.R200C(1)		large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		AGGCACCAGCGAAGAGACAAG	0.592000													16	72					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	858969	858969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:858969C>T	ENST00000314167.4	-	23	3217	c.3107G>A	c.(3106-3108)gGa>gAa	p.G1036E	GAK_ENST00000511163.1_Missense_Mutation_p.G957E|GAK_ENST00000509566.1_5'UTR	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	1036					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GGCAGCCCATCCTCCCAGCAG	0.632000													24	32					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508413	37508413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37508413G>A	ENST00000374660.1	+	40	4061	c.3962G>A	c.(3961-3963)aGg>aAg	p.R1321K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.R1202K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.R1202K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1258						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GAAGCTCAAAGGAAATCCAAA	0.363000													13	54					0	0	1	0	0
ATP1A1	476	broad.mit.edu	37	1	116937852	116937852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:116937852C>T	ENST00000537345.1	+	13	2144	c.1781C>T	c.(1780-1782)cCt>cTt	p.P594L	ATP1A1_ENST00000295598.5_Missense_Mutation_p.P594L|ATP1A1_ENST00000369496.4_Missense_Mutation_p.P563L	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	594					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	ATGATTGACCCTCCACGGGCG	0.522000													16	130					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105330779	105330779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105330779G>A	ENST00000369780.4	+	2	645	c.236G>A	c.(235-237)aGc>aAc	p.S79N	NEURL_ENST00000369777.2_Missense_Mutation_p.S62N	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		79	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ATGGACCTCAGCCACAAGGCT	0.647000													17	120					0	0	1	0	0
OR7D4	125958	broad.mit.edu	37	19	9324872	9324872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9324872G>A	ENST00000308682.2	-	1	670	c.642C>T	c.(640-642)atC>atT	p.I214I		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						AGGAGAAGAGGATCCCAGCTA	0.527000													25	76					0	0	1	0	0
C14orf119	55017	broad.mit.edu	37	14	23566953	23566953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23566953C>T	ENST00000319074.4	+	2	942	c.86C>T	c.(85-87)cCt>cTt	p.P29L	C14orf119_ENST00000554203.1_Missense_Mutation_p.P29L	NM_017924.3	NP_060394.1	Q9NWQ9	CN119_HUMAN	chromosome 14 open reading frame 119	29										central_nervous_system(1)|endometrium(1)|lung(1)	3	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00649)		CCTTCCCCTCCTCTGATGTCT	0.483000													82	200					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75601358	75601358	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:75601358C>T	ENST00000549446.1	-	2	1086	c.406G>A	c.(406-408)Gag>Aag	p.E136K	KCNC2_ENST00000341669.3_Missense_Mutation_p.E136K|KCNC2_ENST00000548513.1_Missense_Mutation_p.E136K|KCNC2_ENST00000550433.1_Missense_Mutation_p.E136K|KCNC2_ENST00000393288.2_Missense_Mutation_p.E136K|KCNC2_ENST00000350228.2_Missense_Mutation_p.E136K|KCNC2_ENST00000540018.1_Missense_Mutation_p.E136K|KCNC2_ENST00000298972.1_Missense_Mutation_p.E136K	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	136					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						GCCAGCTCCTCCTCGAAGAGC	0.662000													20	42					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	56996002	56996002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56996002C>T	ENST00000200676.3	+	1	241	c.111C>T	c.(109-111)ctC>ctT	p.L37L	CETP_ENST00000379780.2_Silent_p.L37L|CETP_ENST00000569082.1_3'UTR	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	37					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						AGCCTGCCCTCCTGGTGTGTA	0.622000													12	43					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107041545	107041545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107041545C>T	ENST00000409886.3	-	20	2965	c.2878G>A	c.(2878-2880)Ggt>Agt	p.G960S	RGPD3_ENST00000304514.7_Missense_Mutation_p.G960S	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	960					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						AAAATCACACCACGGCCCTTC	0.403000													78	284					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91692774	91692774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91692774C>T	ENST00000375835.4	-	3	896	c.590G>A	c.(589-591)gGa>gAa	p.G197E	SHC3_ENST00000375830.1_5'UTR	NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	197	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						CTTGAAGGCTCCCTTCGCACC	0.483000													27	80					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167625888	167625888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167625888C>T	ENST00000519204.1	+	15	2686	c.2568C>T	c.(2566-2568)tcC>tcT	p.S856S	TENM2_ENST00000545108.1_Silent_p.S977S|TENM2_ENST00000518659.1_Silent_p.S977S|TENM2_ENST00000520394.1_Silent_p.S745S|TENM2_ENST00000403607.2_Silent_p.S801S					teneurin transmembrane protein 2																		GAGGTGCTTCCTTGACTCTAC	0.547000													23	98					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25343562	25343562	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25343562G>A	ENST00000354189.5	-	2	216	c.181C>T	c.(181-183)Ccc>Tcc	p.P61S	CASC1_ENST00000545133.1_Intron|CASC1_ENST00000537577.1_Intron|CASC1_ENST00000395987.3_Missense_Mutation_p.P3S|CASC1_ENST00000395990.2_5'UTR|CASC1_ENST00000320267.9_Intron|CASC1_ENST00000557684.1_Intron	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	0	Glu-rich.									breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TTTGCTTTGGGACCCTAAAAG	0.244000													19	48					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72022776	72022776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72022776G>A	ENST00000378743.3	-	20	4226	c.3868C>T	c.(3868-3870)Cca>Tca	p.P1290S		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1290					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CAAAACTTTGGCTTCCACTTT	0.308000													10	42					0	0	1	0	0
TRBV6-9	28598	broad.mit.edu	37	7	142104366	142104366	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142104366C>T	ENST00000390379.1	-	0	98																											TCTGTCCTGTCTTCAGGATGT	0.532000													11	115					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89259965	89259965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89259965G>A	ENST00000289746.2	+	12	2008	c.1943G>A	c.(1942-1944)cGa>cAa	p.R648Q		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	648					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GACGACCTTCGAGACAATGTC	0.672000													12	15					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748099	143748099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143748099C>T	ENST00000408906.2	+	1	639	c.605C>T	c.(604-606)gCt>gTt	p.A202V		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	202			A -> S (in dbSNP:rs6464573).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					ATCTTTGCTGCTTCAGTGTTC	0.582000													37	219					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112686832	112686832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:112686832C>T	ENST00000295408.4	+	2	454	c.197C>T	c.(196-198)tCa>tTa	p.S66L	MERTK_ENST00000409780.1_Intron|MERTK_ENST00000421804.2_Missense_Mutation_p.S66L			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	66					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TTGATGTTTTCACCAACCCAG	0.557000													13	40					0	0	1	0	0
NDC1	55706	broad.mit.edu	37	1	54272177	54272177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54272177G>A	ENST00000371429.3	-	9	1503	c.905C>T	c.(904-906)cCt>cTt	p.P302L	NDC1_ENST00000537333.1_5'UTR|NDC1_ENST00000540001.1_Missense_Mutation_p.P302L|NDC1_ENST00000234725.8_Missense_Mutation_p.P187L	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin									p.P302H(1)									TGGTTGAACAGGAAACACATG	0.348000													21	72					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711077	140711077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140711077G>A	ENST00000517417.1	+	1	826	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.E276K	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCAATGGGGAAGTAACGTA	0.438000													19	51					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103474059	103474059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103474059G>A	ENST00000358392.2	-	15	1996	c.1679C>T	c.(1678-1680)tCa>tTa	p.S560L	COL11A1_ENST00000512756.1_Missense_Mutation_p.S432L|COL11A1_ENST00000353414.4_Missense_Mutation_p.S509L|COL11A1_ENST00000370096.3_Missense_Mutation_p.S548L	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	548	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGCCCCAGATGAACCAGGCCC	0.373000													44	81					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20370265	20370265	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20370265C>T	ENST00000593655.1	-	0	199																											GTAATGCTTTCTTTTTTCTTT	0.418000													10	33					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166221716	166221716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166221716G>A	ENST00000357398.3	+	18	3753	c.3463G>A	c.(3463-3465)Gaa>Aaa	p.E1155K	SCN2A_ENST00000375437.2_Missense_Mutation_p.E1155K|SCN2A_ENST00000375427.2_Missense_Mutation_p.E1155K|SCN2A_ENST00000283256.6_Missense_Mutation_p.E1155K			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1155					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CGCCGAGGGAGAACAGCCTGA	0.413000													23	77					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151171418	151171418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151171418G>A	ENST00000282466.3	-	3	468	c.469C>T	c.(469-471)Ctg>Ttg	p.L157L		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	157					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGTGCACCAGGCGGAGAAAG	0.413000													34	85					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3683150	3683150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3683150G>A	ENST00000294600.2	+	9	1588	c.1504G>A	c.(1504-1506)Gaa>Aaa	p.E502K		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	502										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		GGGGCTCATTGAAAAGGACAA	0.507000													5	54					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62026817	62026817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62026817C>T	ENST00000578147.1	-	15	3001	c.2925G>A	c.(2923-2925)gaG>gaA	p.E975E	SCN4A_ENST00000435607.1_Silent_p.E975E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	975					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CCTCAGGGTCCTCCTCGGGGG	0.642000													8	9					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481366	123481366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123481366G>A	ENST00000280562.5	-	11	1769	c.1564C>T	c.(1564-1566)Ccc>Tcc	p.P522S	PITPNM2_ENST00000320201.4_Missense_Mutation_p.P522S|PITPNM2_ENST00000392428.1_Missense_Mutation_p.P243S|PITPNM2_ENST00000542749.1_Missense_Mutation_p.P522S			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	522					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGGTACTGGGGGGAGGAGGTG	0.617000													24	75					0	0	1	0	0
BMI1	648	broad.mit.edu	37	10	22616968	22616968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:22616968G>A	ENST00000376663.3	+	6	911	c.406G>A	c.(406-408)Gaa>Aaa	p.E136K	COMMD3-BMI1_ENST00000602390.1_Missense_Mutation_p.E279K	NM_005180.8	NP_005171.4			BMI1 polycomb ring finger oncogene											breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|urinary_tract(1)	12						CTTATCCATTGAATTCTTTGA	0.299000													28	79					0	0	1	0	0
KLRG1	10219	broad.mit.edu	37	12	9161639	9161639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9161639G>A	ENST00000266551.4	+	4	441	c.426G>A	c.(424-426)agG>agA	p.R142R	KLRG1_ENST00000538029.1_3'UTR|KLRG1_ENST00000356986.3_Silent_p.R142R	NM_005810.3	NP_005801.3	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G, member 1	142	C-type lectin.				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			breast(1)|central_nervous_system(1)|kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8						CTGGCTGGAGGTGGGAAGATG	0.448000													9	63					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54661819	54661819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54661819C>T	ENST00000474759.1	+	10	1017	c.969C>T	c.(967-969)ttC>ttT	p.F323F	CACNA2D3_ENST00000490478.1_Silent_p.F229F|CACNA2D3_ENST00000288197.5_Silent_p.F323F|CACNA2D3_ENST00000415676.2_Silent_p.F323F	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	323	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTCAGCACTTCAGGGAGCATC	0.418000													8	14					0	0	1	0	0
OR5AN1	390195	broad.mit.edu	37	11	59131945	59131945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59131945G>A	ENST00000313940.2	+	1	61	c.14G>A	c.(13-15)gGa>gAa	p.G5E		NM_001004729.1	NP_001004729.1	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN, member 1	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	21						ACTGGGGGAGGAAATATTACA	0.398000													18	50					0	0	1	0	0
TRBV10-1	28585	broad.mit.edu	37	7	142232050	142232050	+	RNA	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142232050T>G	ENST00000390364.3	-	0	40																											ATCTTGTGTCTCCCAGCCCTG	0.577000													7	35					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990859	39990859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39990859C>T	ENST00000332312.3	-	4	1542	c.1350G>A	c.(1348-1350)agG>agA	p.R450R		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	450						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				GACAGCATCCCCTTGCTCCAC	0.632000													66	111					0	0	1	0	0
ANKLE1	126549	broad.mit.edu	37	19	17394451	17394451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17394451C>T	ENST00000394458.3	+	5	1154	c.878C>T	c.(877-879)tCc>tTc	p.S293F	ANKLE1_ENST00000404085.1_Missense_Mutation_p.S315F|ANKLE1_ENST00000598347.1_Missense_Mutation_p.S293F|ANKLE1_ENST00000594072.1_Missense_Mutation_p.S282F|ANKLE1_ENST00000433424.2_Missense_Mutation_p.S347F	NM_152363.4	NP_689576.4	Q8NAG6	ANKL1_HUMAN	ankyrin repeat and LEM domain containing 1	293						nuclear envelope				large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	7						TCCTCCCCTTCCTCCATGCCT	0.622000													23	79					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901282	51901282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:51901282G>A	ENST00000268919.4	+	1	1044	c.888G>A	c.(886-888)atG>atA	p.M296I		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	296	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GCAAGGGCATGGCCACCTGCT	0.552000													26	74					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505354	159505354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159505354G>A	ENST00000334857.2	-	1	488	c.444C>T	c.(442-444)tcC>tcT	p.S148S		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					CAATGCCAAAGGACCCACACA	0.502000													26	72					0	0	1	0	0
PLAA	9373	broad.mit.edu	37	9	26928394	26928394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:26928394G>A	ENST00000397292.3	-	3	773	c.356C>T	c.(355-357)tCa>tTa	p.S119L	PLAA_ENST00000520884.1_Missense_Mutation_p.S119L	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	119					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TTTTCCAGATGATAGACTACA	0.358000													5	48					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87448052	87448052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:87448052G>A	ENST00000268616.4	-	10	1377	c.1160C>T	c.(1159-1161)cCc>cTc	p.P387L		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	387					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CGACTGCACGGGCCCGACGTG	0.672000													13	43					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181482	128181482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:128181482C>T	ENST00000469083.1	-	2	3164	c.607G>A	c.(607-609)Ggg>Agg	p.G203R	DNAJB8_ENST00000319153.3_Missense_Mutation_p.G203R			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	203					protein folding		heat shock protein binding|unfolded protein binding	p.G203W(1)		kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		CGCTCCTGCCCGTTCTCCACG	0.612000													43	97					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44624497	44624497	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:44624497C>T	ENST00000332990.5	-	6	793	c.777G>A	c.(775-777)caG>caA	p.Q259Q		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	259						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						CAAGAAGCTGCTGTCCTTCCA	0.448000													6	31					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98289599	98289599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:98289599C>T	ENST00000322128.3	-	1	577	c.474G>A	c.(472-474)agG>agA	p.R158R		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	158					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CCTGAGGCCCCCTCCCCGCGG	0.642000													49	113					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95423541	95423541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95423541G>A	ENST00000336148.5	-	4	431	c.307C>T	c.(307-309)Cat>Tat	p.H103Y		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding	p.H103D(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			GGAGCCGAATGAACTACAATT	0.313000								Direct reversal of damage;Homologous recombination					26	39					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71496142	71496142	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71496142C>G	ENST00000296755.7	+	5	7258	c.6960C>G	c.(6958-6960)acC>acG	p.T2320T		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2320						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ACAAGGAGACCAAGAATGCTG	0.507000													43	99					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628411	173628411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173628411C>T	ENST00000333279.2	-	2	207	c.147G>A	c.(145-147)gaG>gaA	p.E49E		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	65										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						TCTGCAAACCCTCTACATCCC	0.453000													20	34					0	0	1	0	0
RNFT2	84900	broad.mit.edu	37	12	117191865	117191865	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117191865G>A	ENST00000257575.4	+	5	860	c.627_splice	c.e5+1	p.K209_splice	RNFT2_ENST00000319176.7_Splice_Site_p.K209_splice|RNFT2_ENST00000407967.3_Splice_Site_p.K209_splice|RNFT2_ENST00000392549.2_Splice_Site_p.K209_splice			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	209						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		TCTCACTGAAGGTGAGTCACT	0.542000													21	52					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565115	20565115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20565115C>T	ENST00000329697.6	-	5	892	c.724G>A	c.(724-726)Gcc>Acc	p.A242T	ACSM2B_ENST00000565322.1_Missense_Mutation_p.A163T|ACSM2B_ENST00000567001.1_Missense_Mutation_p.A242T|ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565232.1_Missense_Mutation_p.A242T	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	242					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TCCATCTTGGCCTTGAGGCCC	0.517000													45	92					0	0	1	0	0
CELF2	10659	broad.mit.edu	37	10	11363309	11363309	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11363309C>T	ENST00000379261.4	+	11	1307	c.1215C>T	c.(1213-1215)agC>agT	p.S405S	CELF2_ENST00000537122.1_Silent_p.S300S|CELF2_ENST00000417956.2_Silent_p.S385S|CELF2_ENST00000354440.2_Silent_p.S387S|CELF2_ENST00000399850.3_Silent_p.S387S|CELF2_ENST00000542579.1_Silent_p.S418S|CELF2_ENST00000427450.1_Silent_p.S387S|CELF2_ENST00000354897.3_Silent_p.S399S|CELF2_ENST00000416382.2_Silent_p.S405S|CELF2_ENST00000315874.3_Silent_p.S387S|CELF2_ENST00000450189.1_Silent_p.S418S	NM_001025077.2	NP_001020248.1	O95319	CELF2_HUMAN	CUGBP, Elav-like family member 2	405	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	16						ACAGCCAGAGCCTGCTGCAGC	0.657000													18	41					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55568937	55568937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55568937C>T	ENST00000395445.1	-	36	5267	c.4873G>A	c.(4873-4875)Gaa>Aaa	p.E1625K	PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395440.1_Missense_Mutation_p.E559K|PCDH15_ENST00000395446.1_Missense_Mutation_p.E821K|PCDH15_ENST00000395442.1_Missense_Mutation_p.E490K|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395438.1_3'UTR	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GACTCAGATTCCTCTTCTGTA	0.458000										HNSCC(58;0.16)			31	50					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100451917	100451917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100451917G>A	ENST00000279907.7	-	14	3350	c.3138C>T	c.(3136-3138)atC>atT	p.I1046I	UHRF1BP1L_ENST00000545232.2_Silent_p.I696I	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1046										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						CAGCTTTAAAGATGGACTCTA	0.358000													30	81					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46308272	46308272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46308272C>T	ENST00000221538.3	-	3	1033	c.891G>A	c.(889-891)ggG>ggA	p.G297G	RSPH6A_ENST00000597055.1_Silent_p.G297G|RSPH6A_ENST00000600188.1_Silent_p.G33G	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	297						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						CTGGTGTCTCCCCCTGCGCAG	0.582000													8	55					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56139555	56139555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56139555C>T	ENST00000319441.4	+	8	1368	c.1204C>T	c.(1204-1206)Ccc>Tcc	p.P402S	PCK1_ENST00000543666.1_Missense_Mutation_p.P85S|PCK1_ENST00000535860.1_Missense_Mutation_p.P299L	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	402					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TTGTGCCCACCCCAACTCGAG	0.592000													34	95					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	56089453	56089453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:56089453G>A	ENST00000373965.2	-	7	1002	c.608C>T	c.(607-609)aCc>aTc	p.T203I	PCDH15_ENST00000395445.1_Missense_Mutation_p.T203I|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.T203I|PCDH15_ENST00000361849.3_Missense_Mutation_p.T203I|PCDH15_ENST00000373957.3_Missense_Mutation_p.T181I|PCDH15_ENST00000395433.1_Missense_Mutation_p.T181I|PCDH15_ENST00000395432.2_Intron|PCDH15_ENST00000395440.1_Missense_Mutation_p.T203I|PCDH15_ENST00000395446.1_Missense_Mutation_p.T203I|PCDH15_ENST00000395442.1_Missense_Mutation_p.T203I|PCDH15_ENST00000373955.1_Missense_Mutation_p.T203I|PCDH15_ENST00000414778.1_Missense_Mutation_p.T208I|PCDH15_ENST00000395430.1_Missense_Mutation_p.T203I|PCDH15_ENST00000320301.6_Missense_Mutation_p.T203I|PCDH15_ENST00000395438.1_Missense_Mutation_p.T203I	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	203	Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AATTTCAAAGGTGTCATTGGA	0.328000										HNSCC(58;0.16)			64	135					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88201751	88201751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:88201751G>A	ENST00000357081.3	-	22	3172	c.3028C>T	c.(3028-3030)Ccc>Tcc	p.P1010S	AGTPBP1_ENST00000432218.1_Intron|AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000376083.3_Missense_Mutation_p.P970S|AGTPBP1_ENST00000376109.3_Missense_Mutation_p.P1022S			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1010					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						CTTACCAAGGGTAAACGCTTC	0.373000													21	85					0	0	1	0	0
CST9	128822	broad.mit.edu	37	20	23584308	23584308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23584308C>T	ENST00000376971.3	-	2	330	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K		NM_001008693.2	NP_001008693.2	Q5W186	CST9_HUMAN	cystatin 9 (testatin)	107						extracellular region	cysteine-type endopeptidase inhibitor activity			central_nervous_system(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Colorectal(13;0.0993)					ATGTCATCTTCAAATTTCCTA	0.473000													15	221					0	0	1	0	0
DDX17	10521	broad.mit.edu	37	22	38884037	38884037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38884037G>A	ENST00000396821.3	-	12	1630	c.1531C>T	c.(1531-1533)Cgt>Tgt	p.R511C	DDX17_ENST00000381633.3_Missense_Mutation_p.R434C|DDX17_ENST00000444597.1_5'UTR	NM_001098504.1|NM_006386.4	NP_001091974.1|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	432					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					TTGGTGCTACGGGCTGTTCGG	0.483000													48	129					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61585240	61585240	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61585240C>T	ENST00000238508.3	+	4	335	c.276C>T	c.(274-276)ttC>ttT	p.F92F		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				ACTCTGATTTCCAAACACTTA	0.353000													22	71					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700713	136700713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:136700713G>A	ENST00000445907.2	+	3	1629	c.1101G>A	c.(1099-1101)aaG>aaA	p.K367K	AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000397608.3_Silent_p.K367K|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000320658.5_Silent_p.K367K|CHRM2_ENST00000402486.3_Silent_p.K367K|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000453373.1_Silent_p.K367K|AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000401861.1_Silent_p.K367K	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	367					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	AGATTGTGAAGATGACTAAGC	0.473000													33	58					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55761768	55761768	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55761768A>G	ENST00000278409.1	-	1	333	c.334T>C	c.(334-336)Tgc>Cgc	p.C112R		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					AAGAGGATGCATTCGGTTGTC	0.473000													44	127					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81702588	81702588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81702588G>A	ENST00000372292.3	-	3	287	c.247C>T	c.(247-249)Cca>Tca	p.P83S		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	83	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			GGCCCAACTGGGCCAGCTTGT	0.577000													41	87					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28136867	28136867	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28136867G>A	ENST00000316334.3	-	5	1036	c.907C>T	c.(907-909)Ctt>Ttt	p.L303F		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	303	PDZ 1.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		GGCTGGGAAAGGACAGCTCGG	0.453000													9	127					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24775148	24775148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24775148G>A	ENST00000221166.5	+	3	2562	c.1780G>A	c.(1780-1782)Gaa>Aaa	p.E594K	NEFM_ENST00000521540.1_Intron|NEFM_ENST00000433454.2_Missense_Mutation_p.E218K|NEFM_ENST00000437366.2_Missense_Mutation_p.E594K|NEFM_ENST00000518131.1_Intron			P07197	NFM_HUMAN	neurofilament, medium polypeptide	594	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		aaagagtgaggaagTGGCTAC	0.488000													11	26					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35255033	35255033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:35255033G>A	ENST00000360310.1	-	14	2348	c.1781C>T	c.(1780-1782)cCc>cTc	p.P594L	BAZ1A_ENST00000382422.2_Missense_Mutation_p.P594L|BAZ1A_ENST00000358716.4_Missense_Mutation_p.P562L	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	594					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CACTAGACTGGGATTGCTCAA	0.428000													12	125					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207872548	207872548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207872548G>A	ENST00000508064.2	+	8	1217	c.1157G>A	c.(1156-1158)gGc>gAc	p.G386D	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	386	Sushi 6.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CAATTAAAAGGCAGCTCTGCT	0.423000											OREG0014195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	93					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98764462	98764462	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98764462G>A	ENST00000266058.4	-	33	3943	c.3698C>T	c.(3697-3699)tCt>tTt	p.S1233F	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Missense_Mutation_p.S1233F	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1233	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GTAGATGGCAGAGCTGGGGTA	0.597000													17	56					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7110373	7110373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7110373G>A	ENST00000306904.5	+	1	209	c.22G>A	c.(22-24)Ggg>Agg	p.G8R		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	8	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGATCGCCCGGGGAAGCTGTT	0.632000													7	31					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197890485	197890485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197890485G>A	ENST00000367390.3	+	4	429	c.402G>A	c.(400-402)tcG>tcA	p.S134S	LHX9_ENST00000367391.1_Silent_p.S134S|LHX9_ENST00000367387.4_Silent_p.S143S|LHX9_ENST00000337020.2_Silent_p.S143S|LHX9_ENST00000561173.1_Silent_p.S149S	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	143	LIM zinc-binding 2.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						TTTCCGCCTCGGAGATGGTCA	0.577000													24	64					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	32109934	32109934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:32109934G>A	ENST00000396184.3	-	2	276	c.72C>T	c.(70-72)atC>atT	p.I24I	PDE1C_ENST00000396191.1_Silent_p.I24I|PDE1C_ENST00000321453.7_Silent_p.I24I|PDE1C_ENST00000396193.1_Intron|PDE1C_ENST00000396182.2_Silent_p.I24I	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	24					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			AGATTTTCTCGATCTGTTCCG	0.512000													18	135					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44777202	44777202	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44777202G>A	ENST00000391958.2	+	5	516	c.389G>A	c.(388-390)aGg>aAg	p.R130K	ZNF235_ENST00000589799.1_Intron|ZNF233_ENST00000592581.1_3'UTR|ZNF233_ENST00000334152.1_Intron	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				CAAGGCAAGAGGTCCAAGTTG	0.383000													20	88					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21489199	21489199	+	Silent	SNP	C	C	T	rs142459106		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21489199C>T	ENST00000313654.9	+	55	7339	c.7098C>T	c.(7096-7098)atC>atT	p.I2366I	LAMA3_ENST00000587184.1_Silent_p.I701I|LAMA3_ENST00000399516.3_Silent_p.I2310I|LAMA3_ENST00000269217.6_Silent_p.I757I|LAMA3_ENST00000588770.1_3'UTR	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2366	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGGAAACATCTCTGACAACA	0.458000													28	86					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6731807	6731807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:6731807G>A	ENST00000405858.1	-	5	1307	c.766C>T	c.(766-768)Ctc>Ttc	p.L256F	ZNF12_ENST00000404360.1_Missense_Mutation_p.L182F|AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000342651.5_Missense_Mutation_p.L218F	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	256					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TGTACAGTGAGGTCCGACATC	0.388000													18	52					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50534694	50534694	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50534694G>A	ENST00000267845.3	-	12	2154	c.1752C>T	c.(1750-1752)tcC>tcT	p.S584S	HDC_ENST00000543581.1_Silent_p.S551S	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	584					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TGCAACTGAGGGAGCGCACCG	0.542000													75	228					0	0	1	0	0
ELF1	1997	broad.mit.edu	37	13	41508052	41508052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:41508052G>A	ENST00000239882.3	-	9	1683	c.1369C>T	c.(1369-1371)Cca>Tca	p.P457S	ELF1_ENST00000498824.1_5'UTR|ELF1_ENST00000442101.1_Missense_Mutation_p.P433S	NM_172373.3	NP_758961.1	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription factor)	457					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		CCTGCTGATGGATCTGTGCTG	0.443000													26	271					0	0	1	0	0
DIO3	1735	broad.mit.edu	37	14	102028226	102028226	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102028226G>A	ENST00000510508.4	+	1	539	c.393G>A	c.(391-393)gaG>gaA	p.E131E	DIO3_ENST00000359323.3_Silent_p.E105E			P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	105					cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(3)|skin(1)	22		all_neural(303;0.185)				AGGCGCACGAGGGCGGTCCGG	0.647000													38	58					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71744131	71744131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71744131C>T	ENST00000258104.3	+	9	1145	c.868C>T	c.(868-870)Cgt>Tgt	p.R290C	DYSF_ENST00000410041.1_Missense_Mutation_p.R322C|DYSF_ENST00000429174.2_Missense_Mutation_p.R290C|DYSF_ENST00000409744.1_Missense_Mutation_p.R291C|DYSF_ENST00000410020.3_Missense_Mutation_p.R322C|DYSF_ENST00000394120.2_Missense_Mutation_p.R291C|DYSF_ENST00000409366.1_Missense_Mutation_p.R291C|DYSF_ENST00000409582.3_Missense_Mutation_p.R321C|DYSF_ENST00000413539.2_Missense_Mutation_p.R321C|DYSF_ENST00000409651.1_Missense_Mutation_p.R322C|DYSF_ENST00000409762.1_Missense_Mutation_p.R321C	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	290	C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GGTAGACTCTCGTTCTCTCAG	0.498000													29	102					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71256160	71256160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71256160C>T	ENST00000260382.5	+	9	1070	c.810C>T	c.(808-810)tcC>tcT	p.S270S	LRRC49_ENST00000544974.2_Silent_p.S260S|LRRC49_ENST00000560691.1_5'UTR|LRRC49_ENST00000443425.2_Silent_p.S226S|LRRC49_ENST00000560369.1_Silent_p.S275S|LRRC49_ENST00000560158.2_Intron|LRRC49_ENST00000436542.2_3'UTR	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	270						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						ACTCTTCTTCCCTCTCGGACA	0.433000													53	332					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47247066	47247066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47247066G>A	ENST00000300404.2	+	11	1736	c.1677G>A	c.(1675-1677)aaG>aaA	p.K559K	B4GALNT2_ENST00000393354.2_Silent_p.K499K|B4GALNT2_ENST00000504681.1_Silent_p.K473K	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	559					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			ACTACTTCAAGAACCATCTCC	0.522000													9	40					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105330819	105330819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105330819C>T	ENST00000369780.4	+	2	685	c.276C>T	c.(274-276)gcC>gcT	p.A92A	NEURL_ENST00000369777.2_Silent_p.A75A	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		92	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TCTGCAACGCCATCACCTTCA	0.662000													22	57					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158590148	158590148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158590148C>T	ENST00000368148.3	-	44	6409	c.6229G>A	c.(6229-6231)Gaa>Aaa	p.E2077K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E2074K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2077					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGCCGAATTTCATTCAGGGAG	0.473000													21	42					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42378415	42378415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42378415G>A	ENST00000290472.3	-	4	477	c.383C>T	c.(382-384)cCc>cTc	p.P128L		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	128					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		ACCCACCTGGGGACTCTGGGA	0.577000													3	4					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154207104	154207104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154207104C>T	ENST00000428931.1	+	5	484	c.317C>T	c.(316-318)tCa>tTa	p.S106L	UBAP2L_ENST00000343815.6_Missense_Mutation_p.S106L|UBAP2L_ENST00000361546.2_Missense_Mutation_p.S106L|UBAP2L_ENST00000271877.7_Missense_Mutation_p.S106L	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	106					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AAGGGAGTCTCAGGCCAGAAG	0.502000													14	51					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38766521	38766521	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38766521G>A	ENST00000310301.4	-	28	2526	c.2472C>T	c.(2470-2472)ccC>ccT	p.P824P	VPS41_ENST00000395969.2_Silent_p.P799P	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	824					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						TGCTGGGCATGGGCAGGCACT	0.512000													21	88					0	0	1	0	0
AKAP3	10566	broad.mit.edu	37	12	4736418	4736418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4736418G>A	ENST00000545990.2	-	5	2174	c.1650C>T	c.(1648-1650)ttC>ttT	p.F550F	AKAP3_ENST00000228850.1_Silent_p.F550F	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	550					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						CAGCTTCAACGAAGCTCCGTG	0.532000													17	40					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30749772	30749772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30749772C>T	ENST00000262518.4	+	34	8796	c.8411C>T	c.(8410-8412)cCc>cTc	p.P2804L	SRCAP_ENST00000344771.4_Missense_Mutation_p.P2646L|SRCAP_ENST00000395059.2_Missense_Mutation_p.P2742L	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2804	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCCTCCCCTCCCATTGGTGGG	0.642000													7	101					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57522848	57522848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57522848G>A	ENST00000420713.1	+	3	348	c.236G>A	c.(235-237)aGa>aAa	p.R79K		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						AATATAAAGAGAAATGAGATG	0.398000													21	125					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99124001	99124001	+	Silent	SNP	C	C	T	rs148650223		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99124001C>T	ENST00000394170.2	+	6	1589	c.1338C>T	c.(1336-1338)atC>atT	p.I446I	ZKSCAN5_ENST00000451158.1_Silent_p.I446I|ZKSCAN5_ENST00000326775.5_Silent_p.I446I	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	446					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CGCATCTGATCGAACACCTAA	0.507000													91	232					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22079283	22079283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22079283C>T	ENST00000454243.2	-	5	1150	c.576G>A	c.(574-576)acG>acA	p.T192T	PHYHIP_ENST00000321613.3_Silent_p.T192T	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	192										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		GGGGCTGGCCCGTGTTGAACT	0.627000													5	10					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33881335	33881335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33881335G>A	ENST00000504830.1	-	2	713	c.378C>T	c.(376-378)ctC>ctT	p.L126L	ADAMTS12_ENST00000352040.3_Silent_p.L126L|ADAMTS12_ENST00000515401.1_Silent_p.L126L	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	126					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.L126L(2)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TAACATGGGAGAGGTTCCCAT	0.502000										HNSCC(64;0.19)			28	86					0	0	1	0	0
IGHV3-21	28444	broad.mit.edu	37	14	106692191	106692191	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106692191C>T	ENST00000390607.2	-	0	12																											GCTAAGGCTCCTCTCTCAGAG	0.527000													23	71					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169535588	169535588	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169535588C>T	ENST00000449804.2	+	2	870	c.825C>T	c.(823-825)ctC>ctT	p.L275L	FOXI1_ENST00000306268.6_Silent_p.L370L	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	370					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTGGTGTCCTCTACCCCAGGG	0.577000									Pendred syndrome				33	85					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107408046	107408046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107408046C>T	ENST00000340010.5	-	20	2433	c.2249G>A	c.(2248-2250)gGa>gAa	p.G750E	SLC26A3_ENST00000422236.2_Missense_Mutation_p.G637E	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	750					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						ATTACGTAATCCTCCATTTGT	0.333000													13	26					0	0	1	0	0
ABCG5	64240	broad.mit.edu	37	2	44052128	44052128	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:44052128G>A	ENST00000260645.1	-	7	943	c.804C>T	c.(802-804)ttC>ttT	p.F268F	ABCG5_ENST00000405322.1_Intron|ABCG5_ENST00000543989.1_Intron	NM_022436.2	NP_071881.1	Q9H222	ABCG5_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 5	268	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCAGCTCTCCGAAGCTCAGGA	0.458000													13	34					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10228227	10228227	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10228227C>T	ENST00000377157.3	+	23	3558	c.2497C>T	c.(2497-2499)Cag>Tag	p.Q833*	UBE4B_ENST00000253251.8_Nonsense_Mutation_p.Q949*|UBE4B_ENST00000343090.6_Nonsense_Mutation_p.Q1078*	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	1078					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TCAGCTTGCTCAGGATGAGCG	0.587000													12	37					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2865964	2865964	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:2865964G>A	ENST00000254695.8	+	5	292	c.201_splice	c.e5-1	p.G68_splice	RAP1GAP2_ENST00000366401.4_Intron|RAP1GAP2_ENST00000540393.2_Splice_Site_p.G49_splice|CTD-3060P21.1_ENST00000574885.1_RNA|RAP1GAP2_ENST00000542807.1_Splice_Site_p.G68_splice	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	68					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GTTTCTATAGGGGATCAAGCT	0.567000													3	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179654826	179654826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179654826C>T	ENST00000589042.1	-	12	2041	c.1817G>A	c.(1816-1818)aGg>aAg	p.R606K	TTN_ENST00000342992.6_Missense_Mutation_p.R606K|TTN_ENST00000360870.5_Missense_Mutation_p.R606K|TTN_ENST00000591111.1_Missense_Mutation_p.R606K|TTN_ENST00000342175.6_Missense_Mutation_p.R560K|TTN_ENST00000359218.5_Missense_Mutation_p.R560K|TTN_ENST00000460472.2_Missense_Mutation_p.R560K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	606							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTGTTTTCCTAGTTTCCTT	0.313000													19	49					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363270	22363270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22363270C>T	ENST00000397121.2	-	3	1566	c.1249G>A	c.(1249-1251)Gga>Aga	p.G417R		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G417*(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GGTTTCTCTCCAGTATGAATT	0.433000													40	117					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87487804	87487804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87487804C>T	ENST00000327946.7	-	10	1426	c.1341G>A	c.(1339-1341)gaG>gaA	p.E447E	GRID1_ENST00000536331.1_Silent_p.E18E	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	447						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCACGAAAGGCTCTTCCTGAG	0.448000										Multiple Myeloma(13;0.14)			46	108					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31743967	31743967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31743967G>A	ENST00000375686.3	-	3	524	c.287C>T	c.(286-288)tCt>tTt	p.S96F	VWA7_ENST00000447450.1_Missense_Mutation_p.S96F|VWA7_ENST00000467576.1_5'UTR|VWA7_ENST00000375688.4_Missense_Mutation_p.S96F	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	96						extracellular region											CCGCCGAGAAGAACCAGGTCC	0.592000													34	91					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117122238	117122238	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117122238G>A	ENST00000307564.4	-	10	2390	c.2229C>T	c.(2227-2229)ccC>ccT	p.P743P	AKNA_ENST00000223791.3_Silent_p.P203P|AKNA_ENST00000374075.5_Silent_p.P662P|AKNA_ENST00000312033.3_Silent_p.P743P|AKNA_ENST00000374088.3_Silent_p.P743P	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	743					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GTCGGGCCAGGGGGTCCTGTG	0.632000													21	37					0	0	1	0	0
HPGDS	27306	broad.mit.edu	37	4	95220653	95220653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:95220653C>T	ENST00000295256.5	-	6	668	c.578G>A	c.(577-579)cGa>cAa	p.R193Q		NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	193	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	TTGGGGCCTTCGTTTTATCCA	0.478000													35	57					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57252863	57252863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57252863G>A	ENST00000343433.6	-	4	1018	c.938C>T	c.(937-939)tCc>tTc	p.S313F	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	313										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TGGAGACAGGGAGCCCTCTTC	0.483000													39	66					0	0	1	0	0
CABYR	26256	broad.mit.edu	37	18	21739707	21739707	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21739707G>A	ENST00000399496.3	+	5	978	c.813G>A	c.(811-813)caG>caA	p.Q271Q	CABYR_ENST00000327201.6_Silent_p.Q173Q|CABYR_ENST00000581397.1_Silent_p.Q271Q|RP11-799B12.4_ENST00000583267.1_lincRNA|CABYR_ENST00000399499.1_Silent_p.Q271Q|CABYR_ENST00000415309.2_Intron	NM_012189.2|NM_153769.1	NP_036321.2|NP_722453.1	O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	0					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					AGGAAGCACAGGGATGGAAAC	0.458000													24	88					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16012579	16012579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16012579G>A	ENST00000350896.3	-	6	1089	c.892C>T	c.(892-894)Cca>Tca	p.P298S	MSR1_ENST00000381998.4_Missense_Mutation_p.P298S|MSR1_ENST00000536385.1_Missense_Mutation_p.P72S|MSR1_ENST00000262101.5_Missense_Mutation_p.P298S|MSR1_ENST00000445506.2_Missense_Mutation_p.P316S|MSR1_ENST00000355282.2_Missense_Mutation_p.P298S	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	298	Collagen-like.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATACCTATTGGACCTGGAAAT	0.398000													20	40					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207176205	207176205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207176205G>A	ENST00000374423.3	+	5	7339	c.6953G>A	c.(6952-6954)gGt>gAt	p.G2318D		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2318							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CGACAGAAAGGTCCTTCTACA	0.483000													17	16					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659107	196659107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196659107C>T	ENST00000312428.6	-	57	10771	c.10671G>A	c.(10669-10671)atG>atA	p.M3557I	DNAH7_ENST00000409063.1_Missense_Mutation_p.M40I	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3557	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGATCGGGTCCATGAGGTATG	0.458000													45	109					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19997289	19997289	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:19997289C>T	ENST00000391403.2	-	1	589	c.486G>A	c.(484-486)atG>atA	p.M162I		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	162						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TCTTGAAGGTCATTTTGGCTT	0.378000													73	140					0	0	1	0	0
RC3H2	54542	broad.mit.edu	37	9	125622214	125622214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125622214G>A	ENST00000373670.1	-	10	2431	c.1831C>T	c.(1831-1833)Cca>Tca	p.P611S	RC3H2_ENST00000423239.2_Missense_Mutation_p.P611S|RC3H2_ENST00000357244.2_Missense_Mutation_p.P611S			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	611	Pro-rich.					cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GGGTACTGTGGGACTTCAAAG	0.353000													33	223					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135140051	135140051	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135140051G>A	ENST00000372169.2	-	27	7878	c.7696C>T	c.(7696-7698)Cag>Tag	p.Q2566*	SETX_ENST00000393220.1_Nonsense_Mutation_p.Q2504*|SETX_ENST00000477049.1_5'UTR|SETX_ENST00000224140.5_Nonsense_Mutation_p.Q2537*			Q7Z333	SETX_HUMAN	senataxin	2537					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CGTGGGTCCTGAAGTTGGTCA	0.502000													14	107					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7231040	7231040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7231040C>T	ENST00000379938.2	+	10	3245	c.2708C>T	c.(2707-2709)tCg>tTg	p.S903L	RREB1_ENST00000334984.6_Missense_Mutation_p.S903L|RREB1_ENST00000379933.3_Missense_Mutation_p.S903L|RREB1_ENST00000349384.6_Missense_Mutation_p.S903L	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	903					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CTGGACTTCTCGCAGAAGGGC	0.597000													33	79					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123699017	123699017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:123699017C>T	ENST00000334268.4	-	17	1530	c.1213G>A	c.(1213-1215)Gaa>Aaa	p.E405K	TRDN_ENST00000398178.3_Missense_Mutation_p.E405K			Q13061	TRDN_HUMAN	triadin	405					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		TTACCTGGTTCCACATGTTTT	0.249000													8	5					0	0	1	0	0
NPAT	4863	broad.mit.edu	37	11	108032498	108032498	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108032498G>A	ENST00000278612.8	-	17	3420	c.3315C>T	c.(3313-3315)tcC>tcT	p.S1105S		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	1105					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		GTTTTAAGGTGGAGGACACAT	0.433000													26	66					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19319212	19319212	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:19319212G>A	ENST00000461366.1	+	14	1835	c.1620G>A	c.(1618-1620)acG>acA	p.T540T		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	540							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						ACTCCTACACGATGCGCTTCT	0.657000													17	18					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77455005	77455005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77455005C>T	ENST00000451710.3	-	5	716	c.479G>A	c.(478-480)aGc>aAc	p.S160N	TRPM6_ENST00000376864.4_Missense_Mutation_p.S160N|TRPM6_ENST00000361255.3_Missense_Mutation_p.S155N|TRPM6_ENST00000360774.1_Missense_Mutation_p.S160N|TRPM6_ENST00000376871.3_Missense_Mutation_p.S160N|TRPM6_ENST00000376872.3_Missense_Mutation_p.S160N|TRPM6_ENST00000449912.2_Missense_Mutation_p.S155N|TRPM6_ENST00000359047.2_Missense_Mutation_p.S160N			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	160					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CAAACCTTGGCTGAAAATCTC	0.453000													19	102					0	0	1	0	0
PRPF3	9129	broad.mit.edu	37	1	150316934	150316934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150316934C>T	ENST00000324862.6	+	12	1716	c.1551C>T	c.(1549-1551)gcC>gcT	p.A517A	PRPF3_ENST00000467329.1_3'UTR|PRPF3_ENST00000543398.1_3'UTR|PRPF3_ENST00000414970.2_Silent_p.A468A	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	517					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		CCAACGCTGCCCGAAAACTCA	0.468000													7	133					0	0	1	0	0
MSX2	4488	broad.mit.edu	37	5	174156247	174156247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:174156247C>T	ENST00000239243.6	+	2	592	c.465C>T	c.(463-465)ctC>ctT	p.L155L	MSX2_ENST00000507785.1_3'UTR	NM_002449.4	NP_002440.2	P35548	MSX2_HUMAN	msh homeobox 2	155					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCCAGCTCCTCGCCCTGGAGC	0.552000													18	45					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87556463	87556463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:87556463G>A	ENST00000436978.1	+	2	534	c.54G>A	c.(52-54)gaG>gaA	p.E18E	PTPN13_ENST00000502971.1_Silent_p.E18E|PTPN13_ENST00000511467.1_Silent_p.E18E|PTPN13_ENST00000427191.2_Silent_p.E18E|PTPN13_ENST00000316707.6_Silent_p.E18E|PTPN13_ENST00000411767.2_Silent_p.E18E	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	18	KIND.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CACTTCAGGAGGAAGAAATAT	0.453000													6	9					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72969065	72969065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72969065G>A	ENST00000261180.4	+	11	2123	c.2027G>A	c.(2026-2028)gGa>gAa	p.G676E	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	676					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTGGACAAAGGAAGCTGGCTG	0.333000													25	57					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51758030	51758030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51758030G>A	ENST00000543196.2	-	5	1129	c.924C>T	c.(922-924)ttC>ttT	p.F308F	GALNT6_ENST00000356317.3_Silent_p.F308F			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	308					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CGGGCTTGGCGAACTCAAAAG	0.582000													17	38					0	0	1	0	0
SH3BGR	6450	broad.mit.edu	37	21	40834415	40834415	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:40834415C>T	ENST00000333634.4	+	2	427	c.349C>T	c.(349-351)Cct>Tct	p.P117S	SH3BGR_ENST00000380637.3_Missense_Mutation_p.P6S|SH3BGR_ENST00000380634.1_Missense_Mutation_p.P6S|SH3BGR_ENST00000380631.1_Missense_Mutation_p.P6S|SH3BGR_ENST00000458295.1_Missense_Mutation_p.P6S	NM_007341.2	NP_031367.1	P55822	SH3BG_HUMAN	SH3 domain binding glutamic acid-rich protein	117					protein complex assembly	cytosol	SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(2)	8		all_cancers(19;1.16e-23)|all_epithelial(19;1.22e-20)|Prostate(19;2.55e-06)|Breast(209;0.0133)		STAD - Stomach adenocarcinoma(101;0.00151)		AGAGAATGTTCCTGGAGAGAA	0.418000													23	50					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62036634	62036634	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62036634G>A	ENST00000578147.1	-	12	2086	c.2010C>T	c.(2008-2010)tcC>tcT	p.S670S	SCN4A_ENST00000435607.1_Silent_p.S670S			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	670					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CCAGACGGAAGGAGCGTAGCA	0.597000													17	49					0	0	1	0	0
C5orf22	55322	broad.mit.edu	37	5	31541450	31541450	+	Silent	SNP	C	C	T	rs142007850	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31541450C>T	ENST00000325366.9	+	6	1060	c.933C>T	c.(931-933)ttC>ttT	p.F311F	C5orf22_ENST00000355907.3_5'UTR	NM_018356.2	NP_060826.2	Q49AR2	CE022_HUMAN	chromosome 5 open reading frame 22	311										kidney(3)|large_intestine(2)|lung(10)|ovary(2)|skin(1)	18						AAGCCACTTTCGCTGATTTGT	0.358000													7	72					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447461	226447461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:226447461G>A	ENST00000272907.6	+	4	1741	c.1328G>A	c.(1327-1329)gGg>gAg	p.G443E	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	443	Pro-rich.																GTCAGCATGGGGAGGTCCCTG	0.632000													25	44					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606746	55606746	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55606746C>T	ENST00000378396.1	+	1	519	c.519C>T	c.(517-519)ttC>ttT	p.F173F		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TTCATGGTTTCAACACAATCA	0.438000													8	63					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90650927	90650927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90650927C>T	ENST00000282146.4	+	2	1248	c.807C>T	c.(805-807)gtC>gtT	p.V269V		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	269						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				TCATGGGTGTCTGCTGCATCT	0.532000													36	88					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106285	55106285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55106285G>A	ENST00000453777.1	+	4	396	c.226G>A	c.(226-228)Gag>Aag	p.E76K	LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.E76K|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	76	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity	p.E76K(1)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GATCCCACAGGAGATTGTGAA	0.557000													47	106					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13867921	13867921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13867921G>A	ENST00000265104.4	-	25	4119	c.4015C>T	c.(4015-4017)Ctc>Ttc	p.L1339F	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1339	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CAATCTTGGAGGAATACCTCC	0.448000									Kartagener syndrome				39	92					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77631416	77631416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77631416G>A	ENST00000296043.6	+	3	1384	c.431G>A	c.(430-432)gGg>gAg	p.G144E	SHROOM3_ENST00000473602.1_3'UTR	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	144					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TGGTCAGGAGGGGTTAAACTT	0.567000													17	46					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26165144	26165144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26165144G>A	ENST00000335473.7	+	4	1511	c.1261G>A	c.(1261-1263)Gag>Aag	p.E421K	MYO18B_ENST00000536101.1_Missense_Mutation_p.E421K|MYO18B_ENST00000407587.2_Missense_Mutation_p.E421K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	421						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGCCCCAAAGGAGGTGAGCAC	0.607000													6	18					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66044946	66044946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:66044946C>T	ENST00000503581.1	-	11	2230	c.1693G>A	c.(1693-1695)Gaa>Aaa	p.E565K	EYS_ENST00000393380.2_Missense_Mutation_p.E565K|EYS_ENST00000370616.2_Missense_Mutation_p.E565K|EYS_ENST00000370618.3_Missense_Mutation_p.E565K|EYS_ENST00000370621.3_Missense_Mutation_p.E565K|EYS_ENST00000342421.5_Missense_Mutation_p.E565K	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	565					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GTTGTATTTTCCAGATACATG	0.358000													40	72					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75290181	75290181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75290181G>A	ENST00000339859.4	-	13	1648	c.1548C>T	c.(1546-1548)atC>atT	p.I516I	USP54_ENST00000428547.1_Silent_p.I366I|USP54_ENST00000497106.1_5'UTR|USP54_ENST00000319786.7_Silent_p.I516I|USP54_ENST00000408019.1_Silent_p.I516I|USP54_ENST00000394811.2_5'UTR			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	516					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					GTCTGTTATGGATCATATTGC	0.502000													17	65					0	0	1	0	0
MMP17	4326	broad.mit.edu	37	12	132334539	132334539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:132334539C>T	ENST00000360564.1	+	9	1499	c.1397C>T	c.(1396-1398)cCc>cTc	p.P466L	MMP17_ENST00000535004.1_Missense_Mutation_p.P6L|MMP17_ENST00000535291.1_Missense_Mutation_p.P382L	NM_016155.4	NP_057239.4	Q9ULZ9	MMP17_HUMAN	matrix metallopeptidase 17 (membrane-inserted)	466	Hemopexin-like 3.				proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CCCGGCTACCCCGCCCAGAGC	0.657000													30	44					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82467539	82467539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82467539C>T	ENST00000423517.2	-	15	14554	c.14217G>A	c.(14215-14217)ggG>ggA	p.G4739G	PCLO_ENST00000426442.2_5'UTR|PCLO_ENST00000333891.8_Silent_p.G4739G	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4610	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTTACCCTCTCCCTGGAAGAA	0.328000													8	18					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9730691	9730691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9730691C>T	ENST00000296003.4	+	16	1480	c.1358C>T	c.(1357-1359)tCc>tTc	p.S453F	MTMR14_ENST00000353332.5_Missense_Mutation_p.S453F|MTMR14_ENST00000351233.5_Missense_Mutation_p.S453F|MTMR14_ENST00000420925.1_Missense_Mutation_p.S207F	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	453						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					ATGGAGAGTTCCCCAGGAGCC	0.602000													31	72					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639261	7639261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7639261C>T	ENST00000359156.4	-	10	2494	c.2292G>A	c.(2290-2292)gaG>gaA	p.E764E	CD163_ENST00000541972.1_Silent_p.E752E|CD163_ENST00000396620.3_Silent_p.E797E|CD163_ENST00000432237.2_Silent_p.E764E	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	764	SRCR 7.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CATTAATGGCCTCTCCACAGC	0.532000													60	186					0	0	1	0	0
PLA2G2E	30814	broad.mit.edu	37	1	20249114	20249114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20249114C>T	ENST00000375116.3	-	2	232	c.175G>A	c.(175-177)Gac>Aac	p.D59N		NM_014589.1	NP_055404.1	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE	59					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCACCAGTCAGTCTGGTCC	0.627000													25	59					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187260	140187260	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140187260G>A	ENST00000530339.1	+	1	488	c.488G>A	c.(487-489)gGg>gAg	p.G163E	PCDHA4_ENST00000512229.2_Missense_Mutation_p.G163E|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.G163E|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1												p.G163V(2)		breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGATATCGGGGAGAACGCC	0.522000													31	88					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48603616	48603616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48603616G>A	ENST00000323776.5	+	14	2448	c.2286G>A	c.(2284-2286)gaG>gaA	p.E762E	MYCBPAP_ENST00000436259.2_Silent_p.E725E	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	725					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TCTGCTTGGAGGACTTCAGAA	0.577000													19	153					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849739	98849739	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:98849739G>A	ENST00000554295.1	-	0	1184					NR_033801.1																						TGATTCCACAGAAAAGGACAG	0.498000													16	119					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51696508	51696508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51696508C>T	ENST00000267012.4	-	4	335	c.274G>A	c.(274-276)Gag>Aag	p.E92K	BIN2_ENST00000544402.1_Missense_Mutation_p.E66K|BIN2_ENST00000452142.2_Missense_Mutation_p.E92K|BIN2_ENST00000604560.1_Missense_Mutation_p.E65K	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	92	BAR.					cytoplasm	protein binding	p.E92K(1)		NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						CCGTCCCACTCGCTGCTGTAG	0.473000													69	182					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91657096	91657096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91657096G>A	ENST00000375835.4	-	10	1511	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	SHC3_ENST00000375830.1_5'UTR	NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	402	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						GATGTCCGAGGACCCTGCAAC	0.547000													26	114					0	0	1	0	0
SAMD4A	23034	broad.mit.edu	37	14	55168827	55168827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:55168827C>T	ENST00000251091.5	+	2	549	c.244C>T	c.(244-246)Ctc>Ttc	p.L82F	SAMD4A_ENST00000554335.1_Missense_Mutation_p.L82F|SAMD4A_ENST00000357634.3_Missense_Mutation_p.L81F|SAMD4A_ENST00000555112.1_3'UTR|SAMD4A_ENST00000392067.3_Missense_Mutation_p.L82F	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	82					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						AGTGATTTCCCTCCTGTTAAC	0.423000													15	65					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68280418	68280418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:68280418G>A	ENST00000433211.1	-	11	1662	c.1488C>T	c.(1486-1488)gcC>gcT	p.A496A	CTNNA3_ENST00000373744.4_Silent_p.A496A	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	496					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TGTCATCTACGGCTTCAGTGA	0.358000													41	77					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1536177	1536177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1536177G>A	ENST00000447419.2	-	3	1225	c.1200C>T	c.(1198-1200)tcC>tcT	p.S400S	PTX4_ENST00000293922.1_Silent_p.S395S|PTX4_ENST00000440447.2_3'UTR			Q96A99	PTX4_HUMAN	pentraxin 4, long	400	Pentaxin.					extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						CCAGCACGAGGGACCCTCCGG	0.682000													14	35					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370417	126370417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126370417G>A	ENST00000394329.3	+	9	8259	c.8246G>A	c.(8245-8247)gGg>gAg	p.G2749E	FAT4_ENST00000335110.5_Missense_Mutation_p.G1047E	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2749	Cadherin 26.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCAGACAAAGGGTCCCCGTCT	0.373000													44	99					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56138689	56138689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56138689G>A	ENST00000319441.4	+	6	1031	c.867G>A	c.(865-867)ggG>ggA	p.G289G	PCK1_ENST00000543666.1_Intron|PCK1_ENST00000535860.1_Silent_p.G157G	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	289					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GCGCCTGCGGGAAGACCAACC	0.547000													47	84					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	67022482	67022482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67022482C>T	ENST00000529006.2	+	21	3891	c.3445C>T	c.(3445-3447)Ctc>Ttc	p.L1149F	KDM2A_ENST00000398645.2_3'UTR|KDM2A_ENST00000530342.1_Missense_Mutation_p.L710F|KDM2A_ENST00000308783.5_Missense_Mutation_p.L607F|KDM2A_ENST00000526258.1_3'UTR	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	1149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						CATCAACAGCCTCTACTGCCT	0.532000													3	12					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422852	26422852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26422852G>A	ENST00000335473.7	+	43	7162	c.6912G>A	c.(6910-6912)agG>agA	p.R2304R	MYO18B_ENST00000536101.1_Silent_p.R2304R|MYO18B_ENST00000407587.2_Silent_p.R2305R	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2304						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TCTCGCTGAGGGTTGGGGCAA	0.607000													13	26					0	0	1	0	0
PTPRA	5786	broad.mit.edu	37	20	3002768	3002768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3002768C>T	ENST00000216877.6	+	14	1603	c.1203C>T	c.(1201-1203)gaC>gaT	p.D401D	PTPRA_ENST00000356147.3_Silent_p.D401D|PTPRA_ENST00000380393.3_Silent_p.D410D|PTPRA_ENST00000425918.2_Silent_p.D421D|PTPRA_ENST00000399903.2_Silent_p.D410D|PTPRA_ENST00000318266.5_Silent_p.D401D|PTPRA_ENST00000358719.4_Silent_p.D266D	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	410	Tyrosine-protein phosphatase 1.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GCTGGCCAGACTTTGGGGTGC	0.562000													32	94					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236902625	236902625	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236902625G>A	ENST00000366578.4	+	10	1066	c.900G>A	c.(898-900)acG>acA	p.T300T	ACTN2_ENST00000542672.1_Silent_p.T300T|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_Intron	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	300					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding	p.T300T(1)		endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TTCGTCGCACGATCCCCTGGC	0.532000													61	141					0	0	1	0	0
MIOX	55586	broad.mit.edu	37	22	50927995	50927995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50927995C>T	ENST00000395732.3	+	9	693	c.671C>T	c.(670-672)cCc>cTc	p.P224L	MIOX_ENST00000395733.3_Intron|MIOX_ENST00000216075.6_Missense_Mutation_p.P224L			Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	224					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	13		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCTTCTACCCCTGGCACACG	0.682000													16	28					0	0	1	0	0
MRAP	56246	broad.mit.edu	37	21	33684189	33684189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:33684189G>A	ENST00000399784.2	+	5	588	c.401G>A	c.(400-402)gGg>gAg	p.G134E	URB1_ENST00000382751.3_3'UTR|MRAP_ENST00000497833.1_3'UTR|MRAP_ENST00000339944.4_Intron|MRAP_ENST00000399786.3_Intron|MRAP_ENST00000303645.5_Missense_Mutation_p.G134E	NM_178817.3	NP_848932.1	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	134					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			endometrium(1)|large_intestine(2)|lung(3)	6						TTGCCCCTCGGGGGTTTCCAG	0.662000													21	44					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141722084	141722084	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141722084G>T	ENST00000475668.2	+	7	781	c.727G>T	c.(727-729)Ggg>Tgg	p.G243W	MGAM_ENST00000549489.2_Missense_Mutation_p.G243W			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	243	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTCGAGCATTGGGCCCCTACT	0.522000													12	60					2.27111e-07	2.27712e-07	1	1	0
GPR98	84059	broad.mit.edu	37	5	89938713	89938713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89938713G>A	ENST00000405460.2	+	13	2504	c.2408G>A	c.(2407-2409)gGg>gAg	p.G803E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	803					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CGATCAAGGGGGTCCCTTGTT	0.408000													40	107					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179597799	179597799	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:179597799G>A	ENST00000467460.1	-	5	753	c.423C>T	c.(421-423)gcC>gcT	p.A141A	PEX5L_ENST00000472994.1_Silent_p.A82A|PEX5L_ENST00000468741.1_5'UTR|PEX5L_ENST00000464614.1_Intron|PEX5L_ENST00000392649.3_Intron|PEX5L_ENST00000263962.8_Silent_p.A139A|PEX5L_ENST00000485199.1_Silent_p.A106A|PEX5L_ENST00000476138.1_Silent_p.A98A|PEX5L_ENST00000467440.2_Intron|PEX5L-AS1_ENST00000466064.1_RNA|PEX5L_ENST00000465751.1_Silent_p.A117A	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	141					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CAGATCCATCGGCCTTTTTCT	0.517000													19	74					0	0	1	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337041	22337041	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22337041G>A	ENST00000390436.2	+	0	22																											GGAAGAACAAGGATGACATCC	0.423000													16	30					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65499330	65499330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65499330C>T	ENST00000261883.4	-	4	380	c.214G>A	c.(214-216)Gag>Aag	p.E72K		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	72					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TCCAGCCGCTCATAGTCGCCC	0.612000													21	21					0	0	1	0	0
CIDEA	1149	broad.mit.edu	37	18	12274239	12274239	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:12274239G>A	ENST00000320477.9	+	4	543	c.478G>A	c.(478-480)Gac>Aac	p.D160N	CIDEA_ENST00000521296.1_3'UTR	NM_001279.3	NP_001270.1	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a	160					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity	p.D194N(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)	13						CGTGTCCTACGACATCCGGTG	0.587000													26	67					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69171531	69171531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:69171531C>T	ENST00000420581.2	-	1	186	c.7G>A	c.(7-9)Gag>Aag	p.E3K	LMOD3_ENST00000475434.1_Missense_Mutation_p.E3K|LMOD3_ENST00000489031.1_Missense_Mutation_p.E3K	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	3						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		CTGCTGTGCTCTGACATTATT	0.333000													11	21					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237246931	237246931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:237246931G>A	ENST00000409907.3	-	17	2325	c.2051C>T	c.(2050-2052)cCc>cTc	p.P684L	IQCA1_ENST00000309507.5_Missense_Mutation_p.P681L|IQCA1_ENST00000431676.2_Missense_Mutation_p.P643L			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	684							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						AGCATCGAAGGGACGCCGTGT	0.488000													22	48					0	0	1	0	0
CRYBB2	1415	broad.mit.edu	37	22	25620922	25620922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25620922C>T	ENST00000398215.2	+	3	263	c.92C>T	c.(91-93)tCg>tTg	p.S31L		NM_000496.2	NP_000487.1	P43320	CRBB2_HUMAN	crystallin, beta B2	31	Beta/gamma crystallin 'Greek key' 1.				response to stimulus|visual perception		structural constituent of eye lens			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	10						CAAGGCCACTCGCATGAGCTC	0.547000													24	43					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23410745	23410745	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23410745C>T	ENST00000379361.4	+	3	1970	c.1110C>T	c.(1108-1110)gaC>gaT	p.D370D		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	370	SSD.				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TCTATGCAGACTCCATGCTCT	0.468000													17	42					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46930755	46930755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46930755C>T	ENST00000264318.3	-	9	2134	c.1152G>A	c.(1150-1152)ttG>ttA	p.L384L		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	384					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTCTCATGTTCAAATTGGCAT	0.318000													16	43					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61505556	61505556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:61505556G>A	ENST00000398571.2	-	40	5355	c.5279C>T	c.(5278-5280)gCc>gTc	p.A1760V		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1760					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TCTTGCCAAGGCATCTAAGTC	0.269000													11	20					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13112081	13112081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:13112081G>A	ENST00000319217.7	-	43	5913	c.5666C>T	c.(5665-5667)cCt>cTt	p.P1889L	MPDZ_ENST00000381015.4_Missense_Mutation_p.P1889L|MPDZ_ENST00000538841.1_Missense_Mutation_p.P748L|MPDZ_ENST00000447879.1_Missense_Mutation_p.P1856L|MPDZ_ENST00000381022.2_Missense_Mutation_p.P1860L|MPDZ_ENST00000541718.1_Missense_Mutation_p.P1860L|MPDZ_ENST00000541093.1_Missense_Mutation_p.P123L|MPDZ_ENST00000536827.1_Missense_Mutation_p.P1827L|MPDZ_ENST00000546205.1_Missense_Mutation_p.P1903L	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1889	PDZ 12.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		AATAAATATAGGCACATCACC	0.473000													14	23					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018992	161018992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161018992C>T	ENST00000368013.3	-	12	2139	c.1819G>A	c.(1819-1821)Gaa>Aaa	p.E607K	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.E607K|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.E430K	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	607					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AGGAAAACTTCCTCCCCATTT	0.572000													68	153					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027525	37027525	+	Missense_Mutation	SNP	G	G	A	rs139443110		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37027525G>A	ENST00000358047.3	+	1	1094	c.1042G>A	c.(1042-1044)Gag>Aag	p.E348K		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	348										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGAGCCTCCCGAGACTGGAGT	0.627000													61	48					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171254565	171254565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171254565G>A	ENST00000354841.4	+	8	1612	c.1481G>A	c.(1480-1482)cGa>cAa	p.R494Q	FMO1_ENST00000402921.2_Missense_Mutation_p.R431Q|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.R494Q			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	494					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGTGGGACCGAACATTCAAG	0.478000													46	37					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10555862	10555862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10555862C>T	ENST00000583535.1	-	4	310	c.223G>A	c.(223-225)Gag>Aag	p.E75K	MYH3_ENST00000226209.7_Missense_Mutation_p.E75K	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	75	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TACACATCCTCTGGTTTGACC	0.463000													34	51					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160851014	160851014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160851014G>A	ENST00000326245.3	-	5	609	c.494C>T	c.(493-495)tCc>tTc	p.S165F	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	165	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCTCAGCAGGGAGCTGTTTCT	0.567000													48	90					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169086465	169086465	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169086465G>A	ENST00000359299.3	+	6	654	c.468G>A	c.(466-468)atG>atA	p.M156I		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	156							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		ATACTCTCATGAACTTGGTCC	0.323000													46	72					0	0	1	0	0
TBC1D5	9779	broad.mit.edu	37	3	17279774	17279774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:17279774G>A	ENST00000253692.7	-	17	3133	c.1469C>T	c.(1468-1470)tCc>tTc	p.S490F	TBC1D5_ENST00000446818.2_Missense_Mutation_p.S490F|TBC1D5_ENST00000429924.2_Missense_Mutation_p.S442F|TBC1D5_ENST00000429383.4_Missense_Mutation_p.S490F|TBC1D5_ENST00000414318.2_5'UTR	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	490						intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						AACAGAGGAGGAGCTACTGCT	0.512000													14	55					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10273996	10273996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10273996G>A	ENST00000396573.2	-	3	582	c.273C>T	c.(271-273)tcC>tcT	p.S91S	GRIN2A_ENST00000404927.2_Silent_p.S91S|GRIN2A_ENST00000562109.1_Silent_p.S91S|GRIN2A_ENST00000330684.3_Silent_p.S91S|GRIN2A_ENST00000396575.2_Silent_p.S91S	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	91					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGCGTGCCCCGGACATGAGGT	0.637000													27	110					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347137	57347137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57347137G>A	ENST00000361249.3	+	5	580	c.484G>A	c.(484-486)Gaa>Aaa	p.E162K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	162	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CCTGACCCAGGAAGATGCTCA	0.458000													37	93					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36459857	36459857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:36459857G>A	ENST00000265748.2	+	11	2170	c.1949G>A	c.(1948-1950)aGa>aAa	p.R650K	ANLN_ENST00000396068.2_Missense_Mutation_p.R613K	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	650	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						AAATTCCAAAGAACTCGTGTC	0.433000													27	82					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529546	57529546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57529546G>A	ENST00000420713.1	+	4	1491	c.1379G>A	c.(1378-1380)gGa>gAa	p.G460E		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						ATTCATACTGGAGAGAAACCC	0.358000													8	10					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32089063	32089063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32089063G>A	ENST00000375201.4	-	6	577	c.532C>T	c.(532-534)Ctc>Ttc	p.L178F	ATF6B_ENST00000375203.3_Missense_Mutation_p.L181F			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	181					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						TCGGCTGAGAGCAGGGAGGCC	0.537000													5	22					0	0	1	0	0
TMEM57	55219	broad.mit.edu	37	1	25812187	25812187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:25812187C>T	ENST00000374343.4	+	8	1576	c.1397C>T	c.(1396-1398)gCc>gTc	p.A466V	TMEM57_ENST00000399766.3_Missense_Mutation_p.A239V|TMEM57_ENST00000399763.3_Missense_Mutation_p.A108V	NM_018202.4	NP_060672.2	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	466						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part				breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCAGGAAGCCCGAAGTTTT	0.428000													28	119					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210595031	210595031	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:210595031C>T	ENST00000360351.4	+	15	5900	c.5394C>T	c.(5392-5394)tcC>tcT	p.S1798S	MAP2_ENST00000361559.4_Silent_p.S442S|MAP2_ENST00000392194.1_Silent_p.S442S|MAP2_ENST00000447185.1_Silent_p.S1794S|MAP2_ENST00000199940.6_Silent_p.S530S	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1798					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GCAATGTCTCCTCGTCTGGAA	0.547000													11	50					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216348787	216348787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216348787G>A	ENST00000366943.2	-	21	4820	c.4434C>T	c.(4432-4434)atC>atT	p.I1478I	USH2A_ENST00000366942.3_Silent_p.I1478I|USH2A_ENST00000307340.3_Silent_p.I1478I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1478					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGTGCTGTTGATTCCTTTAA	0.418000										HNSCC(13;0.011)			17	49					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50744969	50744969	+	Missense_Mutation	SNP	G	G	A	rs104895477		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50744969G>A	ENST00000300589.2	+	4	1252	c.1147G>A	c.(1147-1149)Gag>Aag	p.E383K		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	383	NACHT.		E -> K (in BS).		activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TGGCTTTGACGAGTTCAAGTT	0.542000													24	55					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33584242	33584242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33584242G>A	ENST00000262873.7	+	27	3255	c.3163G>A	c.(3163-3165)Gcc>Acc	p.A1055T		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1013						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CCACCAACAGGCCCTGGGTGA	0.657000													18	17					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61747817	61747817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:61747817C>T	ENST00000577390.1	-	10	2536	c.1582G>A	c.(1582-1584)Gga>Aga	p.G528R	CDH8_ENST00000577730.1_Missense_Mutation_p.G528R|CDH8_ENST00000299345.6_Missense_Mutation_p.G528R|CDH8_ENST00000580044.1_5'UTR	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	528	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AAATAATGTCCGTTTTTGGGA	0.378000													44	35					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45817280	45817280	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45817280G>A	ENST00000358525.4	-	4	670	c.555C>T	c.(553-555)atC>atT	p.I185I	SLC6A20_ENST00000353278.4_Silent_p.I185I|SLC6A20_ENST00000456124.2_Silent_p.I185I	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	185					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		TGCCACGCAGGATGCACAGGT	0.657000													31	73					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59545008	59545008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59545008C>T	ENST00000393853.4	+	5	702	c.539C>T	c.(538-540)cCc>cTc	p.P180L	TBX4_ENST00000240335.1_Missense_Mutation_p.P180L			P57082	TBX4_HUMAN	T-box 4	180					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CACCTGGACCCCTTTGGCCAT	0.602000													27	73					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409179	105409179	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105409179C>T	ENST00000333244.5	-	7	12728	c.12609G>A	c.(12607-12609)gaG>gaA	p.E4203E	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4203						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCAGGGGGCCCTCCGGGAGTT	0.652000													81	190					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167164253	167164253	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167164253C>T	ENST00000476257.1	-	9	1366	c.1068G>A	c.(1066-1068)gtG>gtA	p.V356V	SERPINI2_ENST00000264677.4_Silent_p.V356V|SERPINI2_ENST00000471111.1_Silent_p.V356V|SERPINI2_ENST00000461846.1_Silent_p.V356V			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	356					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						GACTCATGATCACAGGGATGT	0.318000													24	106					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28971146	28971146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28971146G>A	ENST00000359747.4	+	7	819	c.790G>A	c.(790-792)Gat>Aat	p.D264N	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.D264N|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	264	Cadherin 2.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGACGTCAACGATAATTTCCC	0.388000													29	72					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53327118	53327118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:53327118C>T	ENST00000395631.2	-	13	1884	c.1668G>A	c.(1666-1668)atG>atA	p.M556I	FERMT2_ENST00000343279.4_Missense_Mutation_p.M563I|FERMT2_ENST00000557255.1_5'UTR|FERMT2_ENST00000553373.1_Missense_Mutation_p.M563I|FERMT2_ENST00000399304.3_Missense_Mutation_p.M563I|FERMT2_ENST00000341590.3_Missense_Mutation_p.M556I			Q96AC1	FERM2_HUMAN	fermitin family member 2	556	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					GAATAAATCTCATCTTGGCTT	0.403000													9	54					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160049500	160049500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:160049500C>T	ENST00000327245.5	-	14	2559	c.1713G>A	c.(1711-1713)aaG>aaA	p.K571K	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	571					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAGGGAAGCCTTGGCAGGTC	0.522000													29	58					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26222391	26222391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26222391G>A	ENST00000335473.7	+	14	2961	c.2711G>A	c.(2710-2712)gGa>gAa	p.G904E	MYO18B_ENST00000536101.1_Missense_Mutation_p.G904E|MYO18B_ENST00000407587.2_Missense_Mutation_p.G904E	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	904	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AAGATGACAGGAGTGGACTGT	0.562000													29	83					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451179	138451179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138451179C>T	ENST00000344876.4	-	1	2450	c.2064G>A	c.(2062-2064)atG>atA	p.M688I	PCDH18_ENST00000507846.1_Missense_Mutation_p.M468I|PCDH18_ENST00000412923.2_Missense_Mutation_p.M688I|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	688	Cadherin 6.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TTACTGAAGTCATTGCTGTAC	0.408000													70	170					0	0	1	0	0
LDHA	3939	broad.mit.edu	37	11	18425294	18425294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18425294C>T	ENST00000422447.3	+	6	919	c.646C>T	c.(646-648)Cca>Tca	p.P216S	LDHA_ENST00000540430.1_Missense_Mutation_p.P245S|LDHA_ENST00000379412.5_Missense_Mutation_p.P216S|LDHA_ENST00000396222.2_Missense_Mutation_p.P216S|LDHA_ENST00000227157.4_Missense_Mutation_p.P216S|LDHA_ENST00000430553.2_Missense_Mutation_p.P158S|LDHA_ENST00000542179.1_Missense_Mutation_p.P216S	NM_001135239.1|NM_005566.3	NP_001128711.1|NP_005557.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	216					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	GACTCTGCACCCAGATTTAGG	0.383000													11	111					0	0	1	0	0
NACC2	138151	broad.mit.edu	37	9	138903368	138903368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138903368G>A	ENST00000371753.1	-	5	1816	c.1758C>T	c.(1756-1758)acC>acT	p.T586T	NACC2_ENST00000277554.2_Silent_p.T586T			Q96BF6	NACC2_HUMAN	NACC family member 2, BEN and BTB (POZ) domain containing	586					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization	nuclear body				endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5						CCGCTTACAAGGTCCCTGCAT	0.647000													30	48					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68021793	68021793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68021793G>A	ENST00000412757.2	-	11	1833	c.1168C>T	c.(1168-1170)Cgt>Tgt	p.R390C	DPEP2_ENST00000393847.1_Missense_Mutation_p.R390C|DPEP2_ENST00000572888.1_Missense_Mutation_p.R390C			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	390					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		AGGTTTCCACGAAGGACACCC	0.562000													31	179					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135205499	135205499	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135205499G>A	ENST00000372169.2	-	10	1668	c.1486C>T	c.(1486-1488)Cct>Tct	p.P496S	SETX_ENST00000393220.1_Missense_Mutation_p.P496S|SETX_ENST00000224140.5_Missense_Mutation_p.P496S			Q7Z333	SETX_HUMAN	senataxin	496					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCAGTGGTAGGAAGCTTGGCA	0.428000													19	91					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16272764	16272764	+	Missense_Mutation	SNP	C	C	T	rs57794451	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16272764C>T	ENST00000205557.7	-	18	2335	c.2306G>A	c.(2305-2307)aGa>aAa	p.R769K		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	769	ABC transporter 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		AGCTGCCTTTCTGTATACAGC	0.602000													17	48					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124317829	124317829	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124317829G>C	ENST00000409039.3	+	26	4385	c.4360G>C	c.(4360-4362)Ggg>Cgg	p.G1454R		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1454	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGATTTGTGGGGCCTTTTCT	0.433000													3	31					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7656797	7656797	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7656797C>G	ENST00000299492.4	+	14	1597	c.1209C>G	c.(1207-1209)aaC>aaG	p.N403K	PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000533792.1_Missense_Mutation_p.N245K|PPFIBP2_ENST00000528883.1_Missense_Mutation_p.N291K|PPFIBP2_ENST00000530181.1_Missense_Mutation_p.N260K	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	403					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGGATGGGAACCAGCCCTTCC	0.418000													14	87					0	0	1	0	0
TRIM22	10346	broad.mit.edu	37	11	5730827	5730827	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5730827C>T	ENST00000379965.3	+	8	1723	c.1446C>T	c.(1444-1446)ttC>ttT	p.F482F	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	482	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		ATCCGTATTTCAATCCTTGGA	0.483000													35	178					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56954746	56954746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56954746C>T	ENST00000497933.1	+	2	965	c.818C>T	c.(817-819)cCt>cTt	p.P273L		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	243						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						TGCCGGGGCCCTCCTGAAGTC	0.592000													37	127					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46060385	46060385	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46060385C>T	ENST00000295452.4	-	7	932	c.763_splice	c.e7-1	p.G255_splice		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	255					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TAACATAATCCCCTGTAAGAA	0.279000													22	54					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21546459	21546459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21546459C>T	ENST00000415912.2	-	19	2379	c.2254G>A	c.(2254-2256)Gaa>Aaa	p.E752K	ECE1_ENST00000436918.2_Missense_Mutation_p.E736K|ECE1_ENST00000264205.6_Missense_Mutation_p.E765K|ECE1_ENST00000374893.6_Missense_Mutation_p.E768K|ECE1_ENST00000357071.4_Missense_Mutation_p.E756K	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	768					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TACCAGACTTCGCACTTGTGA	0.617000													23	54					0	0	1	0	0
ATP5S	27109	broad.mit.edu	37	14	50789441	50789441	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:50789441A>T	ENST00000426751.2	+	3	1002	c.365A>T	c.(364-366)aAc>aTc	p.N122I	ATP5S_ENST00000358473.1_Intron|ATP5S_ENST00000245448.6_Intron|ATP5S_ENST00000311459.7_Intron|ATP5S_ENST00000554438.1_Intron	NM_015684.3	NP_056499.2	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)	0					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			breast(2)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)|stomach(1)	12	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)		CACATGGGTAACTACCCTATC	0.433000													6	65					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28233854	28233854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28233854G>A	ENST00000305242.5	-	11	1516	c.1424C>T	c.(1423-1425)tCa>tTa	p.S475L	ARMC4_ENST00000537576.1_Missense_Mutation_p.S167L|ARMC4_ENST00000545014.1_5'UTR|ARMC4_ENST00000480504.1_5'UTR	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	475							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						ATCCCTCATTGAACACAACGC	0.448000													42	82					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138738312	138738312	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138738312C>T	ENST00000242351.5	-	12	2650	c.2334G>A	c.(2332-2334)atG>atA	p.M778I	ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.M900I	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	778	PARP catalytic.				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						CTTCTTCCTTCATCTGCGATT	0.388000													30	98					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	132888043	132888043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:132888043C>T	ENST00000370818.3	-	3	943	c.498G>A	c.(496-498)atG>atA	p.M166I	GPC3_ENST00000543339.1_Missense_Mutation_p.M112I|GPC3_ENST00000394299.2_Missense_Mutation_p.M166I	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	166						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					ATTCATTGACCATGTCATCTA	0.458000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				84	56					0	0	1	0	0
OR1K1	392392	broad.mit.edu	37	9	125562841	125562841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125562841G>A	ENST00000277309.2	+	1	472	c.440G>A	c.(439-441)gGa>gAa	p.G147E		NM_080859.1	NP_543135.1	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K, member 1	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(8)|lung(2)|ovary(1)|skin(4)|stomach(1)	17						GCCCTGGTGGGAATGGCATGG	0.617000													23	63					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179609144	179609144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179609144G>A	ENST00000444136.1	+	10	1941	c.1691G>A	c.(1690-1692)gGa>gAa	p.G564E	TDRD5_ENST00000367614.1_Missense_Mutation_p.G564E|TDRD5_ENST00000294848.8_Missense_Mutation_p.G564E	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	564	Tudor.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CCAGACTTTGGAAATATTGGA	0.393000													62	170					0	0	1	0	0
PNLDC1	154197	broad.mit.edu	37	6	160240299	160240299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160240299C>T	ENST00000275275.5	+	18	1585	c.1414C>T	c.(1414-1416)Ctg>Ttg	p.L472L	PNLDC1_ENST00000392167.3_Silent_p.L483L	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1	472						integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GCGGAACATCCTGAAGGAGTA	0.602000													17	24					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242383335	242383335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:242383335G>A	ENST00000442594.2	-	6	923	c.414C>T	c.(412-414)caC>caT	p.H138H	PLD5_ENST00000427495.1_Silent_p.H168H|PLD5_ENST00000536534.1_Silent_p.H230H	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	230						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CGATATACACGTGCTGTTTGT	0.527000													16	49					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78071053	78071053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78071053G>A	ENST00000397545.4	+	19	3058	c.3031G>A	c.(3031-3033)Gag>Aag	p.E1011K		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1011					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GGCCACCGATGAGTGCACCAA	0.572000													20	80					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66067164	66067164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:66067164C>T	ENST00000349533.6	+	9	1269	c.1084C>T	c.(1084-1086)Ccc>Tcc	p.P362S	LEPR_ENST00000371058.1_Missense_Mutation_p.P362S|LEPR_ENST00000371059.3_Missense_Mutation_p.P362S|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371060.3_Missense_Mutation_p.P362S|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000344610.8_Missense_Mutation_p.P362S	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	362	Ig-like.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CAAGATTGTTCCCTCAAAAGA	0.348000													10	79					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123797160	123797160	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123797160A>C	ENST00000223642.1	-	5	534	c.505T>G	c.(505-507)Tca>Gca	p.S169A		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	169					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCAACTTCTGATCCTTCAGGA	0.299000													6	29					0	0	1	0	0
TM6SF1	53346	broad.mit.edu	37	15	83781639	83781639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83781639C>T	ENST00000322019.9	+	2	457	c.183C>T	c.(181-183)gaC>gaT	p.D61D	TM6SF1_ENST00000565774.1_Silent_p.D61D|TM6SF1_ENST00000564988.1_3'UTR|TM6SF1_ENST00000379386.4_Silent_p.D61D|TM6SF1_ENST00000379390.6_Silent_p.D61D			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	61						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						CACCCCGGGACCCACTGTTCT	0.478000													23	143					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12845054	12845054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12845054G>A	ENST00000456430.2	+	2	177	c.136G>A	c.(136-138)Gag>Aag	p.E46K	CAND2_ENST00000295989.5_Missense_Mutation_p.E46K	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	46					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CGAGGACAGCGAGCGCAAGGT	0.602000													10	52					0	0	1	0	0
ZDHHC3	51304	broad.mit.edu	37	3	44974644	44974644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44974644G>A	ENST00000296127.3	-	5	849	c.576C>T	c.(574-576)ttC>ttT	p.F192F	ZDHHC3_ENST00000342790.4_Silent_p.F226F|ZDHHC3_ENST00000424952.2_Silent_p.F192F	NM_016598.2	NP_057682.1	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3	192						Golgi membrane|integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		GCAGGAAGTGGAATCCCACCA	0.522000													19	71					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12300456	12300456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:12300456G>A	ENST00000261349.4	-	15	3317	c.3241C>T	c.(3241-3243)Cct>Tct	p.P1081S	LRP6_ENST00000543091.1_Missense_Mutation_p.P1081S	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1081	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TCAATTTTAGGAGACCTTTCC	0.408000													47	160					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94697645	94697645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94697645G>A	ENST00000304338.3	+	5	663	c.509G>A	c.(508-510)cGg>cAg	p.R170Q		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	170						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GAAACCCTACGGCATGAGGTA	0.338000													33	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575520	179575520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179575520C>T	ENST00000589042.1	-	98	28528	c.28304G>A	c.(28303-28305)aGa>aAa	p.R9435K	TTN_ENST00000342992.6_Missense_Mutation_p.R8191K|TTN_ENST00000591111.1_Missense_Mutation_p.R9118K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9118	Ig-like 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCGTATTTCTCTGCTGTCTTT	0.507000													20	70					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8651042	8651042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8651042C>T	ENST00000270328.4	-	21	2890	c.2624G>A	c.(2623-2625)aGg>aAg	p.R875K	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.R875K|ADAMTS10_ENST00000595838.1_Missense_Mutation_p.R362K			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	875	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GGCGCGCTGCCTTTTGGGCAG	0.662000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	28					0	0	1	0	0
C22orf29	79680	broad.mit.edu	37	22	19838896	19838896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19838896G>A	ENST00000405640.1	-	2	1557	c.889C>T	c.(889-891)Ccc>Tcc	p.P297S	GNB1L_ENST00000405009.1_Intron|C22orf29_ENST00000407472.1_Missense_Mutation_p.P297S|C22orf29_ENST00000484072.1_Intron|GNB1L_ENST00000403325.1_Intron|GNB1L_ENST00000460402.1_Intron|GNB1L_ENST00000329517.6_Intron|C22orf29_ENST00000328554.4_Missense_Mutation_p.P297S			Q7L3V2	CV029_HUMAN	chromosome 22 open reading frame 29	297	Pro-rich.									NS(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	7	Colorectal(54;0.0993)					ACAGGTGTGGGGGCTGCCTCC	0.612000													22	37					0	0	1	0	0
CXCL12	6387	broad.mit.edu	37	10	44871439	44871439	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:44871439C>T	ENST00000374426.2	-	4	345	c.308G>A	c.(307-309)gGa>gAa	p.G103E	CXCL12_ENST00000395795.4_Intron|CXCL12_ENST00000395793.3_Intron|CXCL12_ENST00000374429.2_Intron	NM_001033886.2	NP_001029058.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	0					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	CTTCTTTTTTCCTATCTTTTC	0.408000													31	103					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70255709	70255709	+	Silent	SNP	C	C	T	rs149150723		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:70255709C>T	ENST00000342771.4	+	19	3828	c.3507C>T	c.(3505-3507)tcC>tcT	p.S1169S	AUTS2_ENST00000406775.2_Silent_p.S1145S	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	1169	His-rich.									breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GGCTCCACTCCGTGCACCCCG	0.701000													15	56					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43907535	43907535	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43907535C>T	ENST00000314537.5	+	6	735	c.510C>T	c.(508-510)ttC>ttT	p.F170F	CRHR1_ENST00000293493.7_5'UTR|CRHR1_ENST00000352855.5_Silent_p.F130F|CRHR1_ENST00000339069.5_Silent_p.F69F|CRHR1_ENST00000398285.3_Silent_p.F199F|CRHR1_ENST00000577353.1_Silent_p.F170F	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	199					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		CCACCTGGTTCGTGGTCCAGC	0.632000													25	34					0	0	1	0	0
PSPN	5623	broad.mit.edu	37	19	6375600	6375600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6375600C>T	ENST00000245810.1	-	2	175	c.176G>A	c.(175-177)cGc>cAc	p.R59H	PSPN_ENST00000597721.1_Silent_p.A87A	NM_004158.2	NP_004149.1	O60542	PSPN_HUMAN	persephin	59					axon guidance|central nervous system development		growth factor activity			lung(1)|ovary(1)|skin(1)	3						CAGGGCTCGGCGCAGGCGGGC	0.662000													5	11					0	0	1	0	0
TATDN2	9797	broad.mit.edu	37	3	10291178	10291178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10291178C>T	ENST00000287652.4	+	2	1345	c.294C>T	c.(292-294)tcC>tcT	p.S98S	RP11-438J1.1_ENST00000450534.1_Silent_p.S41S|TATDN2_ENST00000448281.2_Silent_p.S98S	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	98						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						GGGCCGCCTCCAAAGGCTGCC	0.612000													60	174					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54305292	54305292	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54305292G>A	ENST00000545554.1	+	1	192	c.192G>A	c.(190-192)aaG>aaA	p.K64K	UNC13C_ENST00000537900.1_Silent_p.K64K|UNC13C_ENST00000260323.11_Silent_p.K64K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	64					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCACTGTAAAGAAGATTGCAA	0.423000													12	56					0	0	1	0	0
CXorf67	340602	broad.mit.edu	37	X	51150631	51150631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:51150631C>T	ENST00000342995.2	+	1	865	c.763C>T	c.(763-765)Cct>Tct	p.P255S						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						TCATCTAGACCCTGCTCGTCT	0.682000													10	6					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	13984545	13984545	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:13984545G>A	ENST00000310358.7	+	0	632							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		CTTCTCCGACGAGACCCTGGA	0.711000													4	4					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87069667	87069667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87069667C>T	ENST00000265723.4	-	13	1519	c.1408G>A	c.(1408-1410)Gaa>Aaa	p.E470K	ABCB4_ENST00000359206.3_Missense_Mutation_p.E470K|ABCB4_ENST00000545634.1_Missense_Mutation_p.E470K|ABCB4_ENST00000358400.3_Missense_Mutation_p.E470K|ABCB4_ENST00000453593.1_Missense_Mutation_p.E470K	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	470	ABC transporter 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CCAATGATTTCCCTCAGATAG	0.358000													28	50					0	0	1	0	0
ELMOD1	55531	broad.mit.edu	37	11	107506466	107506466	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:107506466C>T	ENST00000265840.7	+	6	660	c.395C>T	c.(394-396)cCc>cTc	p.P132L	ELMOD1_ENST00000443271.2_Missense_Mutation_p.P132L|ELMOD1_ENST00000531234.1_Missense_Mutation_p.P126L	NM_018712.3	NP_061182.3	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1	132					phagocytosis	cytoskeleton	GTPase activator activity			endometrium(2)|large_intestine(5)|liver(2)|lung(7)|pancreas(2)|prostate(1)	19		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		TCTGATAATCCCCAACATGAA	0.458000													9	32					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241494457	241494457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241494457G>A	ENST00000401804.1	-	3	300	c.162C>T	c.(160-162)gcC>gcT	p.A54A	ANKMY1_ENST00000405002.1_5'UTR|ANKMY1_ENST00000272972.3_5'UTR|ANKMY1_ENST00000462004.1_5'UTR|ANKMY1_ENST00000361678.4_Silent_p.A54A|ANKMY1_ENST00000536462.1_Silent_p.A7A|ANKMY1_ENST00000403283.1_Silent_p.A133A|ANKMY1_ENST00000373318.2_Silent_p.A54A|ANKMY1_ENST00000391987.1_5'UTR|ANKMY1_ENST00000406958.1_Silent_p.A54A|ANKMY1_ENST00000373320.4_5'UTR|ANKMY1_ENST00000405523.3_Silent_p.A54A			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	0							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CCTTCTCAGGGGCTGCTGAAA	0.602000													56	77					0	0	1	0	0
RPN2	6185	broad.mit.edu	37	20	35860728	35860728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35860728C>T	ENST00000237530.6	+	14	1922	c.1611C>T	c.(1609-1611)ccC>ccT	p.P537P	RPN2_ENST00000373622.5_Silent_p.P505P|RPN2_ENST00000470352.1_Intron	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	537					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				AGAAGAGGCCCCCCACCGTGG	0.572000													39	179					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30507767	30507767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30507767G>A	ENST00000356798.6	+	15	1892	c.1712G>A	c.(1711-1713)gGg>gAg	p.G571E	ITGAL_ENST00000358164.5_Missense_Mutation_p.G488E|ITGAL_ENST00000433423.2_Intron	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	571					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CGGATAGAAGGGACCCAAGTG	0.577000													13	129					0	0	1	0	0
ARMC9	80210	broad.mit.edu	37	2	232127033	232127033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:232127033C>T	ENST00000349938.4	+	12	1235	c.1041C>T	c.(1039-1041)tcC>tcT	p.S347S	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	347							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TGACCACATCCCATCCTGGAG	0.478000													32	115					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189873680	189873680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189873680C>T	ENST00000304636.3	+	48	3726	c.3556C>T	c.(3556-3558)Cct>Tct	p.P1186S	COL3A1_ENST00000317840.5_Missense_Mutation_p.P883S	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1186	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GCAACCAGGCCCTCCTGGACC	0.557000													25	90					0	0	1	0	0
NHSL2	340527	broad.mit.edu	37	X	71360216	71360216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:71360216G>A	ENST00000373677.1	+	2	2982	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	NHSL2_ENST00000510661.1_Missense_Mutation_p.E709K|NHSL2_ENST00000540800.1_Missense_Mutation_p.E940K|NHSL2_ENST00000535692.1_Missense_Mutation_p.E574K			F5H593	F5H593_HUMAN	NHS-like 2	940										NS(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(10)|lung(7)|stomach(1)	28	Renal(35;0.156)					AAGCCCAGGGGAGTCAACAGC	0.542000													18	12					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2595311	2595311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2595311C>T	ENST00000399655.1	+	6	1064	c.799C>T	c.(799-801)Ccc>Tcc	p.P267S	CACNA1C_ENST00000347598.4_Missense_Mutation_p.P267S|CACNA1C_ENST00000399591.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000480911.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000344100.3_Missense_Mutation_p.P267S|CACNA1C_ENST00000399597.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000335762.5_Missense_Mutation_p.P267S|CACNA1C_ENST00000399595.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399603.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399617.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399606.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399621.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399601.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399638.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399649.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399644.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399629.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000327702.7_Missense_Mutation_p.P267S|CACNA1C_ENST00000399634.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399637.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000406454.3_Missense_Mutation_p.P267S|CACNA1C_ENST00000402845.3_Missense_Mutation_p.P267S|CACNA1C_ENST00000399641.1_Missense_Mutation_p.P267S	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	267					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGCCATGGTCCCCCTGCTGCA	0.562000													5	21					0	0	1	0	0
OGT	8473	broad.mit.edu	37	X	70787583	70787583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70787583C>T	ENST00000373719.3	+	20	3040	c.2823C>T	c.(2821-2823)acC>acT	p.T941T	OGT_ENST00000373701.3_Silent_p.T931T	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	941					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					GGGCAGGGACCCCCATGGTGA	0.507000													13	10					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15565261	15565261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15565261G>A	ENST00000343625.6	-	13	2151	c.2071C>T	c.(2071-2073)Ccc>Tcc	p.P691S		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	691					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						TAACCACTGGGGGCAGCATCC	0.557000											OREG0025322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	38					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53741697	53741697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53741697C>T	ENST00000333952.4	-	5	448	c.283G>A	c.(283-285)Gac>Aac	p.D95N	ZNF677_ENST00000598513.1_Missense_Mutation_p.D95N			Q86XU0	ZN677_HUMAN	zinc finger protein 677	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.D95N(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		TCCTTGAGGTCAAAATTGTTG	0.353000													29	122					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84530438	84530438	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84530438C>T	ENST00000527857.1	+	0	460					NR_026851.1																						CGACTGCTGTCTTGGGAGTCC	0.532000													4	41					0	0	1	0	0
TUBA3E	112714	broad.mit.edu	37	2	130952776	130952776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130952776C>T	ENST00000312988.7	-	3	351	c.251G>A	c.(250-252)aGg>aAg	p.R84K		NM_207312.2	NP_997195.1	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	84					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					GAAGAGCTGCCTGTAGGTCCC	0.507000													42	149					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128840353	128840353	+	Silent	SNP	G	G	A	rs150340160		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128840353G>A	ENST00000310343.9	-	22	4712	c.4713C>T	c.(4711-4713)ccC>ccT	p.P1571P	ARHGAP32_ENST00000392657.3_Silent_p.P1222P|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Silent_p.P1222P	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1571	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GAATGTCTTCGGGGTAACAGG	0.547000													18	45					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39247057	39247057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:39247057C>T	ENST00000518318.2	+	4	391	c.349C>T	c.(349-351)Ctc>Ttc	p.L117F	POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_Missense_Mutation_p.L117F|POU6F2_ENST00000559001.1_Missense_Mutation_p.L109F			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	117					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						CCCCCCAGCCCTCAACCAGCC	0.577000													58	156					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117250683	117250683	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117250683C>T	ENST00000003084.6	+	19	3231	c.3099C>T	c.(3097-3099)ttC>ttT	p.F1033F	AC000111.6_ENST00000456270.1_RNA|CFTR_ENST00000454343.1_Silent_p.F972F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1033	ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GAGCATATTTCCTCCAAACCT	0.388000									Cystic Fibrosis				6	65					0	0	1	0	0
FFAR1	2864	broad.mit.edu	37	19	35842700	35842700	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35842700C>T	ENST00000246553.2	+	1	256	c.246C>T	c.(244-246)ttC>ttT	p.F82F		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	82					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GCCCCGTCTTCGCGGTGGCCC	0.701000													4	10					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205308499	205308499	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205308499C>T	ENST00000367156.3	-	7	1396	c.580G>A	c.(580-582)Gtc>Atc	p.V194I	KLHDC8A_ENST00000460687.1_Missense_Mutation_p.V60I|KLHDC8A_ENST00000539253.1_Missense_Mutation_p.V194I|KLHDC8A_ENST00000537168.1_Missense_Mutation_p.V81I|KLHDC8A_ENST00000367155.3_Missense_Mutation_p.V194I	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	194										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ATGTCAAAGACCTCGAAAGCG	0.567000													5	29					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170062006	170062006	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170062006G>A	ENST00000263816.3	-	41	7983	c.7698C>T	c.(7696-7698)taC>taT	p.Y2566Y		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2566					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CATCCACCCAGTAGAGAAGGT	0.483000													20	95					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073721	9073721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9073721C>T	ENST00000397910.4	-	3	13928	c.13725G>A	c.(13723-13725)ggG>ggA	p.G4575G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4577	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAAGAGCGTCCCCCATGCTGG	0.532000													15	45					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7621837	7621837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7621837G>A	ENST00000256861.6	-	9	1377	c.1299C>T	c.(1297-1299)atC>atT	p.I433I	ITIH5_ENST00000298441.6_Silent_p.I219I|ITIH5_ENST00000446830.2_Silent_p.I215I|ITIH5_ENST00000397146.2_Silent_p.I433I|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Silent_p.I433I	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	433	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CAATGGTGAAGATGCAGACTT	0.617000													27	67					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45670725	45670725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45670725C>T	ENST00000270172.3	-	10	1360	c.877G>A	c.(877-879)Gaa>Aaa	p.E293K	AP001059.5_ENST00000442785.1_RNA|DNMT3L_ENST00000418993.1_Missense_Mutation_p.E293K	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	293					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		TCCAGGTCTTCCTTGTTCAGC	0.642000													19	69					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100813667	100813667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100813667C>T	ENST00000323346.5	+	12	1813	c.1500C>T	c.(1498-1500)gtC>gtT	p.V500V	SLC17A8_ENST00000392989.3_Silent_p.V450V|SLC17A8_ENST00000552697.1_3'UTR	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	500					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TCTATGGGGTCTTTGCTTCTG	0.463000													27	69					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13919431	13919431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13919431C>T	ENST00000265104.4	-	7	933	c.829G>A	c.(829-831)Gaa>Aaa	p.E277K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	277	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCATCCGCTTCCTTCAGCAGC	0.483000									Kartagener syndrome				23	274					0	0	1	0	0
PSKH1	5681	broad.mit.edu	37	16	67942812	67942812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67942812G>A	ENST00000291041.5	+	2	330	c.160G>A	c.(160-162)Gca>Aca	p.A54T		NM_006742.2	NP_006733.1	P11801	KPSH1_HUMAN	protein serine kinase H1	54						endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|pancreas(1)	12		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)		CGGGTTCCCAGCAGCAAGTCA	0.602000													10	31					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333646	70333646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70333646C>T	ENST00000338508.4	-	32	2754	c.2755G>A	c.(2755-2757)Ggg>Agg	p.G919R	SHANK2_ENST00000423696.2_Missense_Mutation_p.G539R|SHANK2_ENST00000409161.1_Missense_Mutation_p.G322R|SHANK2_ENST00000449833.2_Missense_Mutation_p.G323R			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	539					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding	p.G919R(1)|p.G323R(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTAATCGTCCCGTAGACTCTT	0.607000													14	23					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45059290	45059290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45059290C>T	ENST00000429094.2	-	13	1925	c.1421G>A	c.(1420-1422)aGa>aAa	p.R474K	NELL2_ENST00000395487.2_Missense_Mutation_p.R473K|NELL2_ENST00000333837.4_Missense_Mutation_p.R497K|NELL2_ENST00000551601.1_Missense_Mutation_p.R473K|NELL2_ENST00000549027.1_Missense_Mutation_p.R473K|NELL2_ENST00000452445.2_Missense_Mutation_p.R474K|NELL2_ENST00000437801.2_Missense_Mutation_p.R524K	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	474	EGF-like 2; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		ATCATCAATTCTGATGTATCC	0.348000													25	38					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116931269	116931269	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116931269C>T	ENST00000356083.3	+	3	1825	c.1434C>T	c.(1432-1434)acC>acT	p.T478T		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	478	Pro-rich.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						GCACCAGCACCCACAAACCTC	0.562000													48	206					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54778665	54778665	+	Missense_Mutation	SNP	G	G	A	rs150493192	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54778665G>A	ENST00000391748.1	-	14	1793	c.1666C>T	c.(1666-1668)Ccc>Tcc	p.P556S	LILRB2_ENST00000391746.1_3'UTR|LILRB2_ENST00000314446.5_Missense_Mutation_p.P556S|LILRB2_ENST00000434421.1_Missense_Mutation_p.P441S|LILRB2_ENST00000391749.4_Missense_Mutation_p.P557S	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	557					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACATCCTGGGGGGCTTCAGAT	0.637000													29	67					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45134824	45134824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45134824G>A	ENST00000296129.1	-	6	1706	c.1572C>T	c.(1570-1572)ttC>ttT	p.F524F		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	524	CUB.					extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CCTCTTGTTGGAAGCTGGGGG	0.547000													32	74					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862802	10862802	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10862802C>T	ENST00000559480.1	+	0	98																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GTGAAGAAGCCTGGGGCCTCA	0.572000													33	197					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25308672	25308672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25308672G>A	ENST00000400358.4	+	22	2938	c.2881G>A	c.(2881-2883)Gga>Aga	p.G961R	SGSM1_ENST00000400359.4_Missense_Mutation_p.G1016R	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	1016	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						CTTCCCCCACGGAGGCGCCAT	0.512000													4	39					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16535241	16535241	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:16535241G>A	ENST00000334133.4	-	2	408	c.136C>T	c.(136-138)Ctg>Ttg	p.L46L		NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	46						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						CCAGCACTCAGAGTCGTGAAC	0.547000													70	207					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90321118	90321118	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90321118C>T	ENST00000469640.2	+	27	3582	c.3207C>T	c.(3205-3207)gtC>gtT	p.V1069V	DAPK1_ENST00000358077.5_Silent_p.V1044V|DAPK1_ENST00000408954.3_Silent_p.V1044V|DAPK1_ENST00000472284.1_Silent_p.V1044V|DAPK1_ENST00000491893.1_Silent_p.V978V			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1044					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						GCACAAACGTCCTGGGGAAGT	0.627000									Chronic Lymphocytic Leukemia, Familial Clustering of				10	40					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189526084	189526084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189526084C>T	ENST00000264731.3	+	4	437	c.348C>T	c.(346-348)ctC>ctT	p.L116L	TP63_ENST00000392461.3_Silent_p.L22L|TP63_ENST00000418709.2_Silent_p.L116L|TP63_ENST00000449992.1_Intron|TP63_ENST00000437221.1_Silent_p.L22L|TP63_ENST00000320472.5_Silent_p.L116L|TP63_ENST00000392463.2_Silent_p.L22L|TP63_ENST00000392460.3_Silent_p.L116L|TP63_ENST00000456148.1_Silent_p.L22L|TP63_ENST00000382063.4_Intron|TP63_ENST00000354600.5_Silent_p.L22L|TP63_ENST00000440651.2_Silent_p.L116L	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	116					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCTGGGGCTCCTGAACAGCA	0.572000										HNSCC(45;0.13)			39	82					0	0	1	0	0
FAIM3	9214	broad.mit.edu	37	1	207085271	207085271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207085271C>T	ENST00000367091.3	-	4	657	c.514G>A	c.(514-516)Gtc>Atc	p.V172I	FAIM3_ENST00000528654.1_Intron|FAIM3_ENST00000442471.2_Missense_Mutation_p.V60I|FAIM3_ENST00000420007.2_Missense_Mutation_p.V172I	NM_005449.4	NP_005440.1	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3	172					anti-apoptosis|cellular defense response	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(84;0.201)					ACTGGAGGGACCTTGCCCCTT	0.542000											OREG0014185	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	30					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42204020	42204020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42204020G>A	ENST00000541110.1	-	16	3617	c.3049C>T	c.(3049-3051)Ccc>Tcc	p.P1017S	TRERF1_ENST00000340840.2_Missense_Mutation_p.P914S|TRERF1_ENST00000354325.2_Missense_Mutation_p.P914S|TRERF1_ENST00000372917.4_Missense_Mutation_p.P914S|TRERF1_ENST00000372922.4_Missense_Mutation_p.P997S			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	997	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCCTCCGTGGGAGCCAGGACG	0.627000													6	21					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133475156	133475156	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133475156C>T	ENST00000402696.3	+	6	1151	c.666C>T	c.(664-666)gcC>gcT	p.A222A	TF_ENST00000264998.3_Silent_p.A95A	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	222	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GGGATGTGGCCTTTGTCAAGC	0.517000													3	25					0	0	1	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51770657	51770657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51770657G>A	ENST00000316401.7	+	5	822	c.441G>A	c.(439-441)aaG>aaA	p.K147K	SIGLECL1_ENST00000597824.1_Silent_p.K53K|SIGLECL1_ENST00000593968.1_3'UTR|CTD-3187F8.2_ENST00000597569.1_RNA	NM_173635.1	NP_775906.1			SIGLEC family like 1																		AGCAGGCGAAGAAAGCTGCAG	0.468000													58	115					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15614330	15614330	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15614330G>A	ENST00000378076.3	-	25	2870	c.2517C>T	c.(2515-2517)atC>atT	p.I839I		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	839					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CCACCTCCAGGATGGTGTCAC	0.443000													39	92					0	0	1	0	0
CCT6B	10693	broad.mit.edu	37	17	33266229	33266229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33266229G>A	ENST00000314144.5	-	10	1301	c.1186C>T	c.(1186-1188)Cgt>Tgt	p.R396C	CCT6B_ENST00000421975.3_Missense_Mutation_p.R359C|CCT6B_ENST00000436961.3_Missense_Mutation_p.R351C	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	396					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding	p.R396C(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				TTGATAGCACGAAGTCCATCT	0.363000													61	94					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20554463	20554463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20554463G>A	ENST00000329697.6	-	11	1571	c.1403C>T	c.(1402-1404)tCc>tTc	p.S468F	ACSM2B_ENST00000565322.1_Missense_Mutation_p.S389F|ACSM2B_ENST00000567001.1_Missense_Mutation_p.S468F|ACSM2B_ENST00000565232.1_Missense_Mutation_p.S468F	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	468					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TCACCCGCTGGAGTTAATGAT	0.512000													68	385					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100686794	100686794	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100686794A>T	ENST00000306151.4	+	3	12161	c.12097A>T	c.(12097-12099)Aca>Tca	p.T4033S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4033						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TGCAACCAGTACACCTCACAC	0.527000													62	173					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45108503	45108503	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45108503C>T	ENST00000429094.2	-	10	1520	c.1016G>A	c.(1015-1017)cGa>cAa	p.R339Q	NELL2_ENST00000395487.2_Missense_Mutation_p.R338Q|NELL2_ENST00000333837.4_Missense_Mutation_p.R362Q|NELL2_ENST00000551601.1_Missense_Mutation_p.R338Q|NELL2_ENST00000549027.1_Missense_Mutation_p.R338Q|NELL2_ENST00000452445.2_Missense_Mutation_p.R339Q|NELL2_ENST00000437801.2_Missense_Mutation_p.R389Q	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	339	VWFC 2.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		AAAGTAGGTTCGTCCTTGAAA	0.348000													19	59					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275758	71275758	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71275758G>A	ENST00000399575.2	+	3	887	c.713G>A	c.(712-714)aGt>aAt	p.S238N		NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	238					regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				GCCTTTAAAAGTTTTTGGCAA	0.368000													25	68					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905667	15905667	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15905667A>T	ENST00000308940.8	+	1	907	c.809A>T	c.(808-810)gAa>gTa	p.E270V		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CAGTCTCCGGAAGGAGACACC	0.567000													30	53					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73905021	73905021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73905021G>A	ENST00000342056.2	+	15	3138	c.2740G>A	c.(2740-2742)Gaa>Aaa	p.E914K	KCNQ5_ENST00000355635.3_Missense_Mutation_p.E896K|KCNQ5_ENST00000355194.4_Missense_Mutation_p.E895K|KCNQ5_ENST00000370398.1_Missense_Mutation_p.E895K|KCNQ5_ENST00000414165.2_Missense_Mutation_p.E785K|KCNQ5_ENST00000403813.2_Missense_Mutation_p.E886K|KCNQ5_ENST00000402622.2_Missense_Mutation_p.E905K	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	895					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GCCTGCCAGGGAAGCTGCCTT	0.507000													11	140					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71842984	71842984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:71842984C>T	ENST00000373545.3	-	18	2373	c.1935G>A	c.(1933-1935)atG>atA	p.M645I	PHKA1_ENST00000541944.1_Missense_Mutation_p.M645I|PHKA1_ENST00000373539.3_Missense_Mutation_p.M645I|PHKA1_ENST00000339490.3_Missense_Mutation_p.M645I|PHKA1_ENST00000373542.4_Missense_Mutation_p.M645I			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	645					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CATAATCATTCATCCAGTTGC	0.418000													42	28					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15753742	15753742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:15753742G>A	ENST00000285667.3	-	2	215	c.148C>T	c.(148-150)Cct>Tct	p.P50S	HSPA13_ENST00000544452.1_5'UTR|HSPA13_ENST00000478035.1_5'UTR	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	50						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						CCTGTGCCAGGAAAAAACACC	0.423000													25	58					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105763016	105763016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105763016C>T	ENST00000369755.3	+	9	2625	c.2080C>T	c.(2080-2082)Cct>Tct	p.P694S	SLK_ENST00000335753.4_Missense_Mutation_p.P694S	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	694					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TAAAAAAGAGCCTGAAGTTAC	0.368000													30	95					0	0	1	0	0
NANOGP1	404635	broad.mit.edu	37	12	8051682	8051682	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8051682C>T	ENST00000607111.1	+	0	902																				kidney(1)|lung(4)|prostate(1)	6						AGAGAGGTTTCTTTCTTTTTT	0.388000													3	5					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31421725	31421725	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31421725T>C	ENST00000389202.2	+	11	1142	c.1093T>C	c.(1093-1095)Ttc>Ctc	p.F365L		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	365					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGATGGCCTCTTCCTGGGGGC	0.572000													46	86					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128432	83128432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:83128432C>T	ENST00000329312.4	+	4	753	c.716C>T	c.(715-717)tCa>tTa	p.S239L		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	239					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity	p.S238*(1)|p.S239*(1)		NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						GAGATTTGCTCAGAAAATAGT	0.333000													8	28					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26917478	26917478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:26917478G>A	ENST00000539517.2	-	5	1528	c.1211C>T	c.(1210-1212)cCc>cTc	p.P404L	NOVA1_ENST00000465357.2_Missense_Mutation_p.P380L|NOVA1_ENST00000267422.7_Missense_Mutation_p.P282L	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	407	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		GGCAGCTAGGGGAGAAGCAGC	0.502000													20	52					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289148	107289148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107289148G>A	ENST00000277216.3	-	1	342	c.343C>T	c.(343-345)Ctt>Ttt	p.L115F		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						ATCATGCCAAGGAGGAAACAT	0.438000													68	123					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003771	122003771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122003771G>A	ENST00000498619.1	+	7	3438	c.3000G>A	c.(2998-3000)agG>agA	p.R1000R	CASR_ENST00000296154.5_Silent_p.R990R|CASR_ENST00000490131.1_Silent_p.R990R	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	990					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGGCCCACAGGAATTCTACGC	0.577000													15	43					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81697756	81697756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81697756G>A	ENST00000372292.3	-	8	1020	c.980C>T	c.(979-981)cCc>cTc	p.P327L		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	327	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CTCTCCTGTGGGGTAGGTGAA	0.572000													75	196					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61978179	61978179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61978179C>T	ENST00000370263.4	-	6	2016	c.1795G>A	c.(1795-1797)Gac>Aac	p.D599N	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	599					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AAGATGCGGTCGATGACCATG	0.657000													30	59					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183721183	183721183	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183721183C>T	ENST00000511685.1	+	28	7902	c.7779C>T	c.(7777-7779)ttC>ttT	p.F2593F	TENM3_ENST00000406950.2_Silent_p.F2593F					teneurin transmembrane protein 3																		CGCGCAGGTTCGCGGACGTGG	0.692000													8	6					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109124642	109124642	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:109124642C>T	ENST00000261483.4	+	11	2820	c.1768C>T	c.(1768-1770)Cat>Tat	p.H590Y		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	590					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		CAGACTTTTTCATTCGTTAAT	0.303000													17	66					0	0	1	0	0
TBC1D16	125058	broad.mit.edu	37	17	77984429	77984429	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:77984429G>A	ENST00000310924.2	-	3	424	c.309C>T	c.(307-309)tcC>tcT	p.S103S		NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	103						intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			TGCGAACGGGGGAGCTCTCGG	0.701000													6	21					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53418997	53418997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:53418997C>T	ENST00000377942.3	-	3	3114	c.2911G>A	c.(2911-2913)Ggg>Agg	p.G971R	PCDH8_ENST00000338862.4_Missense_Mutation_p.G874R	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	971					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding	p.G971W(2)		breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GCGTTGGGCCCGCTGCAGGAT	0.577000													10	36					0	0	1	0	0
ZNF296	162979	broad.mit.edu	37	19	45579435	45579435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45579435G>A	ENST00000303809.2	-	1	411	c.197C>T	c.(196-198)cCc>cTc	p.P66L		NM_145288.1	NP_660331.1	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	66					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|lung(3)|prostate(1)|urinary_tract(2)	7						GGAGTGGTGGGGTTCGCCGCC	0.741000													3	17					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348302	140348302	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348302G>A	ENST00000289269.5	+	1	2483	c.1951G>A	c.(1951-1953)Gag>Aag	p.E651K	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		651	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGGGAGATGAGAGTGGTAG	0.498000													21	49					0	0	1	0	0
NECAB2	54550	broad.mit.edu	37	16	84024144	84024144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84024144C>T	ENST00000565691.1	+	4	978	c.256C>T	c.(256-258)Ctc>Ttc	p.L86F	NECAB2_ENST00000305202.4_Missense_Mutation_p.L169F			Q7Z6G3	NECA2_HUMAN	N-terminal EF-hand calcium binding protein 2	169	EF-hand 1.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19						GACCCGCTTCCTCCTGAAGGA	0.587000													26	54					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27455079	27455079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27455079C>T	ENST00000264705.4	+	17	2794	c.2632C>T	c.(2632-2634)Ctt>Ttt	p.L878F	CAD_ENST00000403525.1_Missense_Mutation_p.L815F|CAD_ENST00000464159.1_3'UTR	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	878	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	ACAGATTGCCCTTGCAGTTCT	0.567000													22	79					0	0	1	0	0
CCDC81	60494	broad.mit.edu	37	11	86123537	86123537	+	Missense_Mutation	SNP	G	G	A	rs148008941	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:86123537G>A	ENST00000278487.3	+	10	1611	c.532G>A	c.(532-534)Gaa>Aaa	p.E178K	CCDC81_ENST00000354755.1_Missense_Mutation_p.E353K|CCDC81_ENST00000528728.1_Missense_Mutation_p.E178K|CCDC81_ENST00000445632.2_Missense_Mutation_p.E443K			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	443										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				ACAGGAAAACGAAATAAAGCA	0.453000													36	65					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481105	140481105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140481105C>T	ENST00000231130.2	+	1	872	c.872C>T	c.(871-873)aCt>aTt	p.T291I	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		291	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTCGCAAAACTTTTCAGCTA	0.373000													26	55					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44064780	44064780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44064780C>T	ENST00000262726.7	-	16	2039	c.1786G>A	c.(1786-1788)Gaa>Aaa	p.E596K	EFCAB6_ENST00000396231.2_Missense_Mutation_p.E444K	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TGCTGCTGTTCATCTTTTTGT	0.388000													13	134					0	0	1	0	0
TAF2	6873	broad.mit.edu	37	8	120809247	120809247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:120809247G>A	ENST00000378164.2	-	8	1372	c.1074C>T	c.(1072-1074)ttC>ttT	p.F358F		NM_003184.3	NP_003175.1	Q6P1X5	TAF2_HUMAN	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	358					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTCTAGATATGAAACAACCAA	0.383000													21	63					0	0	1	0	0
SEC23B	10483	broad.mit.edu	37	20	18529400	18529400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:18529400C>T	ENST00000336714.3	+	16	2323	c.1891C>T	c.(1891-1893)Cat>Tat	p.H631Y	SEC23B_ENST00000377475.3_Missense_Mutation_p.H631Y|SEC23B_ENST00000377465.1_Missense_Mutation_p.H631Y|SEC23B_ENST00000262544.2_Missense_Mutation_p.H631Y	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	631					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						TTACTCCTTTCATGGGCCACC	0.448000													8	72					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74460664	74460664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74460664G>A	ENST00000394019.2	-	23	2857	c.2460C>T	c.(2458-2460)ttC>ttT	p.F820F	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000359484.4_Silent_p.F718F|SLC4A5_ENST00000358683.4_Silent_p.F718F|SLC4A5_ENST00000357822.5_Silent_p.F820F|SLC4A5_ENST00000346834.4_Silent_p.F820F|SLC4A5_ENST00000377634.4_Silent_p.F820F|SLC4A5_ENST00000377632.1_Silent_p.F820F|SLC4A5_ENST00000423644.1_Silent_p.F820F|SLC4A5_ENST00000483195.1_5'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	820						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGGGGGCCACGAACCAGCCTC	0.622000													11	28					0	0	1	0	0
HMGCR	3156	broad.mit.edu	37	5	74643088	74643088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:74643088C>T	ENST00000287936.4	+	6	666	c.510C>T	c.(508-510)ctC>ctT	p.L170L	HMGCR_ENST00000511206.1_Silent_p.L170L|HMGCR_ENST00000343975.5_Silent_p.L170L	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	170					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CGTTTACCCTCGATGCTCTTG	0.378000													92	225					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169116292	169116292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169116292C>T	ENST00000256935.8	+	9	878	c.798C>T	c.(796-798)ttC>ttT	p.F266F		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	266					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCGGGGCTTCCCTAAGGAGA	0.522000													17	56					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70526179	70526179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:70526179G>A	ENST00000327305.6	-	4	1008	c.351C>T	c.(349-351)ttC>ttT	p.F117F	NETO1_ENST00000299430.2_Silent_p.F116F|NETO1_ENST00000580049.1_5'UTR|NETO1_ENST00000583169.1_Silent_p.F117F|NETO1_ENST00000397929.1_Silent_p.F116F	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	117	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GTTGTCCACAGAAACGTCCAA	0.378000													28	73					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49244174	49244174	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49244174C>T	ENST00000332955.2	-	10	1591	c.1044G>A	c.(1042-1044)agG>agA	p.R348R		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	348					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TTTATTGTTGCCTCGAATCTG	0.512000													18	33					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39666958	39666958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39666958C>T	ENST00000265708.4	-	7	644	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	ADAM2_ENST00000379853.2_Intron|ADAM2_ENST00000347580.4_Intron|ADAM2_ENST00000521880.1_Missense_Mutation_p.E181K	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	181	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ACATGCATTTCTATATACTTT	0.259000													6	29					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43171060	43171060	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:43171060G>A	ENST00000522175.2	+	0	795							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GACATCAGAGGAAGAGCCACA	0.284000													17	53					0	0	1	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157267	65157267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65157267C>T	ENST00000323544.4	+	6	781	c.653C>T	c.(652-654)cCt>cTt	p.P218L	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	218	Pro-rich.									NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						ACCACCAGCCCTGGTGACAGG	0.622000													20	175					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52200089	52200089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52200089G>A	ENST00000354534.5	+	27	4997	c.4819G>A	c.(4819-4821)Gag>Aag	p.E1607K	SCN8A_ENST00000545061.1_Missense_Mutation_p.E1566K	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1607					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AGATATAATTGAGAAATACTT	0.433000													62	160					0	0	1	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940337	67940337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:67940337G>A	ENST00000357461.2	-	3	713	c.304C>T	c.(304-306)Ccc>Tcc	p.P102S	TMEM229B_ENST00000557006.1_Missense_Mutation_p.P102S	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	102						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						TAGTCCCAGGGGCAGGCGTTG	0.627000													4	8					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2297749	2297749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2297749G>A	ENST00000381458.5	+	6	768	c.705G>A	c.(703-705)ggG>ggA	p.G235G	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	235					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	TGCTTGCTGGGAATTGGAGCG	0.532000													31	110					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111394212	111394212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111394212C>T	ENST00000393934.3	+	1	690	c.120C>T	c.(118-120)ccC>ccT	p.P40P	PLCXD2_ENST00000477665.1_Silent_p.P40P	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	40					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CCTCGCTCCCCCCTCACCTCC	0.542000													35	105					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762729	24762729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24762729C>T	ENST00000376451.2	+	2	833	c.573C>T	c.(571-573)gcC>gcT	p.A191A	KIAA1217_ENST00000307544.6_Silent_p.A191A|KIAA1217_ENST00000376452.3_Silent_p.A473A|KIAA1217_ENST00000458595.1_Silent_p.A473A|KIAA1217_ENST00000376462.1_Silent_p.A393A|KIAA1217_ENST00000430453.2_Silent_p.A394A|KIAA1217_ENST00000376454.3_Silent_p.A473A|KIAA1217_ENST00000396445.1_Silent_p.A191A|KIAA1217_ENST00000396446.1_Silent_p.A191A			Q5T5P2	SKT_HUMAN	KIAA1217	473					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CACCCCCTGCCTCTCCTCACA	0.532000													38	84					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50376884	50376884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50376884G>A	ENST00000376020.2	-	4	2214	c.2189C>T	c.(2188-2190)cCa>cTa	p.P730L	SHROOM4_ENST00000460112.3_Missense_Mutation_p.P614L|SHROOM4_ENST00000289292.7_Missense_Mutation_p.P730L	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	730					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					ATTATGCTCTGGAGACCATCT	0.552000													3	21					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219294035	219294035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219294035G>A	ENST00000248444.5	+	7	683	c.595G>A	c.(595-597)Gac>Aac	p.D199N	VIL1_ENST00000440053.1_Missense_Mutation_p.D199N|VIL1_ENST00000392114.2_Intron	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	199	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGATCCGAGACCAGGAGCG	0.617000													34	76					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24197023	24197023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24197023G>A	ENST00000265769.4	+	15	1722	c.1612G>A	c.(1612-1614)Ggg>Agg	p.G538R	RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_Missense_Mutation_p.G285R|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	538	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		GAATGAAGGTGGGTCAAAGTA	0.458000													3	24					0	0	1	0	0
VPS51	738	broad.mit.edu	37	11	64876153	64876153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64876153C>T	ENST00000279281.3	+	5	1302	c.1210C>T	c.(1210-1212)Cgc>Tgc	p.R404C	VPS51_ENST00000527646.1_3'UTR	NM_013265.2	NP_037397.2			vacuolar protein sorting 51 homolog (S. cerevisiae)																		ACGAGTGGCCCGCGAGCGCCT	0.751000													6	6					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38596017	38596017	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38596017G>A	ENST00000413689.1	-	27	4759	c.4566C>T	c.(4564-4566)ttC>ttT	p.F1522F	SCN5A_ENST00000423572.2_Silent_p.F1521F|SCN5A_ENST00000425664.1_Silent_p.F1504F|SCN5A_ENST00000333535.4_Silent_p.F1522F|SCN5A_ENST00000464652.1_5'UTR|SCN5A_ENST00000451551.2_Silent_p.F1468F|SCN5A_ENST00000455624.2_Silent_p.F1521F|SCN5A_ENST00000449557.2_Silent_p.F1468F|SCN5A_ENST00000450102.2_Silent_p.F1468F|SCN5A_ENST00000443581.1_Silent_p.F1521F|SCN5A_ENST00000414099.2_Silent_p.F1504F	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1522					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCACAATGTCGAATATGAAGC	0.502000													44	85					0	0	1	0	0
TDRD3	81550	broad.mit.edu	37	13	61102816	61102816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:61102816C>T	ENST00000196169.3	+	11	1966	c.1178C>T	c.(1177-1179)cCt>cTt	p.P393L	TDRD3_ENST00000377881.2_Missense_Mutation_p.P393L|TDRD3_ENST00000377894.2_Missense_Mutation_p.P393L|TDRD3_ENST00000535286.1_Missense_Mutation_p.P486L	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	393					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		ACTTCATATCCTTTAGGTTCT	0.373000													23	91					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57535160	57535160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57535160C>T	ENST00000243077.3	+	3	660	c.194C>T	c.(193-195)cCa>cTa	p.P65L	LRP1_ENST00000554174.1_Missense_Mutation_p.P65L|LRP1_ENST00000553277.1_Missense_Mutation_p.P65L|LRP1_ENST00000338962.4_Missense_Mutation_p.P65L	NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	65	LDL-receptor class A 1.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCTCAGGTCCACAGAGTAAG	0.577000													14	38					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20434538	20434538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20434538C>T	ENST00000222573.3	+	8	1760	c.1076C>T	c.(1075-1077)cCa>cTa	p.P359L	ITGB8_ENST00000537992.1_Missense_Mutation_p.P224L	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	359	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						CCCCTCTTGCCAGGCACCATT	0.328000													8	63					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40251444	40251444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:40251444G>A	ENST00000302541.6	+	11	2107	c.1765G>A	c.(1765-1767)Gag>Aag	p.E589K	MYRIP_ENST00000444716.1_Missense_Mutation_p.E589K|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Missense_Mutation_p.E500K|MYRIP_ENST00000539167.1_Missense_Mutation_p.E402K|MYRIP_ENST00000425621.1_Missense_Mutation_p.E589K	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	589	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CAGGCTGTACGAGTTAGCAAT	0.493000													32	72					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41316121	41316121	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41316121C>T	ENST00000551295.2	+	5	408	c.291C>T	c.(289-291)aaC>aaT	p.N97N	CNTN1_ENST00000547849.1_Silent_p.N97N|CNTN1_ENST00000547702.1_Silent_p.N97N|CNTN1_ENST00000348761.2_Silent_p.N86N|CNTN1_ENST00000360099.3_Silent_p.N97N|CNTN1_ENST00000347616.1_Silent_p.N97N	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	97	Ig-like C2-type 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TAGGAGGAAACCTTGTTATCA	0.408000													17	74					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50976922	50976922	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:50976922G>A	ENST00000442544.2	+	23	3898	c.3282G>A	c.(3280-3282)aaG>aaA	p.K1094K	DCC_ENST00000581580.1_Silent_p.K729K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1094					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTCCTCAGAAGAACAGCAACC	0.532000													28	56					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55224589	55224589	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55224589C>T	ENST00000413439.1	+	0	1769																											CTTGGTCCACCATCCCCAGCC	0.612000													12	37					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41689911	41689911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41689911C>T	ENST00000313860.7	+	24	3045	c.2991C>T	c.(2989-2991)acC>acT	p.T997T	LIMCH1_ENST00000513024.1_Intron|LIMCH1_ENST00000396595.3_Intron|LIMCH1_ENST00000381753.4_Intron|LIMCH1_ENST00000512946.1_Intron|LIMCH1_ENST00000514096.1_Intron|LIMCH1_ENST00000509277.1_Silent_p.T830T|LIMCH1_ENST00000512820.1_Intron|LIMCH1_ENST00000508501.1_Intron|LIMCH1_ENST00000503057.1_Silent_p.T1381T|LIMCH1_ENST00000512632.1_Intron|LIMCH1_ENST00000511496.1_Intron	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	997					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						GTTCTCCCACCCCTCCCGGTC	0.483000													24	82					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144359486	144359486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:144359486C>T	ENST00000262995.4	+	4	1355	c.928C>T	c.(928-930)Cct>Tct	p.P310S	GAB1_ENST00000262994.4_Missense_Mutation_p.P310S|GAB1_ENST00000505913.1_Missense_Mutation_p.P207S	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	310					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					TTATGACATTCCTCCAACACC	0.413000													31	84					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125281525	125281525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125281525C>T	ENST00000340750.1	+	1	106	c.106C>T	c.(106-108)Ctg>Ttg	p.L36L		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						GGGCATGTACCTGATCACGGT	0.572000													32	167					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16878368	16878368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:16878368G>A	ENST00000377833.4	-	63	10111	c.10046C>T	c.(10045-10047)tCa>tTa	p.S3349L		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3349	CUB 25.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTGAAATCTTGAATTTCCGTG	0.378000													28	83					0	0	1	0	0
TEX37	200523	broad.mit.edu	37	2	88825180	88825180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:88825180C>T	ENST00000303254.3	+	2	160	c.18C>T	c.(16-18)taC>taT	p.Y6Y		NM_152670.2	NP_689883.1			testis expressed 37																		GTGTGAAATACCCGGGACAGG	0.547000													59	155					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7751449	7751449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7751449C>T	ENST00000254846.5	+	11	2232	c.1843C>T	c.(1843-1845)Cac>Tac	p.H615Y	KDM6B_ENST00000448097.2_Missense_Mutation_p.H615Y	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	615	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						TTCCTCCTGCCACCAAAATAC	0.697000													48	53					0	0	1	0	0
VWA1	64856	broad.mit.edu	37	1	1374645	1374645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1374645C>T	ENST00000476993.1	+	3	894	c.816C>T	c.(814-816)ggC>ggT	p.G272G	VWA1_ENST00000404702.3_Silent_p.G60G|VWA1_ENST00000338660.5_3'UTR	NM_022834.4	NP_073745.2	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	272	Fibronectin type-III 1.					basement membrane				NS(1)|breast(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCTGGGCCGGCCTCGACCCGG	0.706000													5	18					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998538	27998538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27998538G>A	ENST00000441525.1	-	1	1028	c.914C>T	c.(913-915)tCa>tTa	p.S305L		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	305										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						ATCTTCACCTGAAGTGAGGAA	0.483000													21	25					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90177088	90177088	+	Silent	SNP	C	C	T	rs141497185		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90177088C>T	ENST00000394412.3	-	12	2497	c.2421G>A	c.(2419-2421)acG>acA	p.T807T		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	807					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CCAGCCGCTCCGTAGCCTGCT	0.637000													14	78					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105769081	105769081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:105769081G>A	ENST00000393127.2	+	7	1259	c.813G>A	c.(811-813)atG>atA	p.M271I	GRIA4_ENST00000530497.1_Missense_Mutation_p.M271I|GRIA4_ENST00000428631.2_Missense_Mutation_p.M271I|GRIA4_ENST00000525187.1_Missense_Mutation_p.M271I|GRIA4_ENST00000282499.5_Missense_Mutation_p.M271I|GRIA4_ENST00000393125.2_Missense_Mutation_p.M271I	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	271					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATACACCTATGGTAATCAAAC	0.353000													21	54					0	0	1	0	0
DYRK4	8798	broad.mit.edu	37	12	4705365	4705365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4705365G>A	ENST00000540757.2	+	5	493	c.333G>A	c.(331-333)ggG>ggA	p.G111G	DYRK4_ENST00000010132.5_Silent_p.G111G|DYRK4_ENST00000543431.1_Silent_p.G111G	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	111	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			AGACAATCGGGAAGGGGTCCT	0.547000													55	96					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13418631	13418631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13418631C>T	ENST00000360228.5	-	15	1950	c.1951G>A	c.(1951-1953)Gat>Aat	p.D651N	CACNA1A_ENST00000573710.2_Missense_Mutation_p.D652N	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	652					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGAAAAGTATCGAAGTTGGTG	0.557000													22	84					0	0	1	0	0
TEKT4	150483	broad.mit.edu	37	2	95540699	95540699	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95540699G>A	ENST00000295201.4	+	4	1029	c.892G>A	c.(892-894)Gag>Aag	p.E298K	AC097374.2_ENST00000568768.1_RNA	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	298					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						CCGCTGTGAGGAGCTGGAGGA	0.682000													7	19					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8176141	8176141	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8176141G>A	ENST00000520004.1	-	6	4008	c.3744C>T	c.(3742-3744)ttC>ttT	p.F1248F	SGK223_ENST00000330777.4_Silent_p.F1248F			Q86YV5	SG223_HUMAN		1248	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity										GGAACTCATCGAACTTGCGGT	0.642000													19	41					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19974856	19974856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:19974856G>A	ENST00000295824.9	-	1	816	c.655C>T	c.(655-657)Ccc>Tcc	p.P219S	EFHB_ENST00000344838.4_Missense_Mutation_p.P89S|EFHB_ENST00000498089.1_5'UTR	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	219					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						TGGCATTGGGGAGGTTCTATC	0.502000													33	86					0	0	1	0	0
KRTAP10-12	386685	broad.mit.edu	37	21	46117623	46117623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46117623C>T	ENST00000400365.3	+	1	537	c.507C>T	c.(505-507)gcC>gcT	p.A169A	TSPEAR_ENST00000323084.4_Intron	NM_198699.1	NP_941972.1	P60413	KR10C_HUMAN	keratin associated protein 10-12	169	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|lung(8)	9						GCTCTGGGGCCTCCTCTCTGT	0.647000													63	275					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119737589	119737589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119737589G>A	ENST00000313400.4	-	10	1887	c.1787C>T	c.(1786-1788)cCt>cTt	p.P596L	ASTN2_ENST00000361209.2_Missense_Mutation_p.P545L|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.P592L			O75129	ASTN2_HUMAN	astrotactin 2	596						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TTTGCTGACAGGAAGCCAGAG	0.552000													15	47					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934998	28934998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28934998C>T	ENST00000257192.4	+	15	3051	c.2839C>T	c.(2839-2841)Cac>Tac	p.H947Y	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG1_ENST00000462981.2_Missense_Mutation_p.H306Y|RP11-534N16.1_ENST00000581856.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	947					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding	p.H947N(1)		NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AGCCAATGCCCACAATGTCAT	0.507000													79	198					0	0	1	0	0
SYTL5	94122	broad.mit.edu	37	X	37935888	37935888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37935888G>A	ENST00000357972.5	+	6	1169	c.623G>A	c.(622-624)cGg>cAg	p.R208Q	TM4SF2_ENST00000465127.1_Intron|SYTL5_ENST00000456733.2_Missense_Mutation_p.R208Q|SYTL5_ENST00000297875.2_Missense_Mutation_p.R208Q			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	208					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						GACACTGGGCGGAGCTATAGC	0.388000													38	30					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117232120	117232120	+	Silent	SNP	C	C	T	rs121908777		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117232120C>T	ENST00000003084.6	+	14	2031	c.1899C>T	c.(1897-1899)ctC>ctT	p.L633L	CFTR_ENST00000454343.1_Silent_p.L572L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	633	ABC transporter 1.		L -> P (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTTCAGAACTCCAAAATCTAC	0.348000									Cystic Fibrosis				40	93					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16882980	16882980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:16882980G>A	ENST00000377833.4	-	61	9795	c.9730C>T	c.(9730-9732)Cct>Tct	p.P3244S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3244	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAGATAAAAGGAGCAGGTACT	0.388000													25	70					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680293	114680293	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114680293G>A	ENST00000393296.1	-	3	972	c.895C>T	c.(895-897)Cac>Tac	p.H299Y	SYT6_ENST00000369547.1_Missense_Mutation_p.H214Y			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	299	C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGGGAAGTGGAAGTTCTCA	0.557000													28	57					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4834515	4834515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:4834515C>T	ENST00000378191.4	+	5	1573	c.1192C>T	c.(1192-1194)Cct>Tct	p.P398S	AJAP1_ENST00000378190.3_Missense_Mutation_p.P398S	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	398	Targeting signals.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GCATCTTATTCCTGTGGCCTT	0.532000													12	117					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101906464	101906464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101906464C>T	ENST00000348070.1	-	14	1791	c.1792G>A	c.(1792-1794)Gaa>Aaa	p.E598K	PCSK6_ENST00000331826.7_Missense_Mutation_p.E433K|PCSK6_ENST00000344273.2_Missense_Mutation_p.E598K|PCSK6_ENST00000398181.2_Missense_Mutation_p.E598K|PCSK6_ENST00000358417.3_Missense_Mutation_p.E598K|PCSK6_ENST00000561177.1_5'UTR	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	599	Homo B/P.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CACTGCCCTTCAGCCTTTTCT	0.502000													26	26					0	0	1	0	0
GLP2R	9340	broad.mit.edu	37	17	9783763	9783763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:9783763C>T	ENST00000262441.5	+	11	1727	c.1214C>T	c.(1213-1215)aCt>aTt	p.T405I	GLP2R_ENST00000574745.1_Missense_Mutation_p.T225I	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	405					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	TCTTTCATCACTGATGATCAA	0.383000													64	93					0	0	1	0	0
AMELX	265	broad.mit.edu	37	X	11316365	11316365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:11316365C>T	ENST00000380712.3	+	5	222	c.154C>T	c.(154-156)Cct>Tct	p.P52S	ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000413512.3_Intron|ARHGAP6_ENST00000380736.1_Intron|AMELX_ENST00000380714.3_Missense_Mutation_p.P38S|ARHGAP6_ENST00000380732.3_Intron|AMELX_ENST00000348912.4_Missense_Mutation_p.P22S|ARHGAP6_ENST00000337414.4_Intron	NM_182680.1	NP_872621.1	Q99217	AMELX_HUMAN	amelogenin, X-linked	38					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel			endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						GGTGCTTACCCCTTTGAAGTG	0.353000													68	117					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16861084	16861084	+	Missense_Mutation	SNP	G	G	A	rs148029259	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16861084G>A	ENST00000524140.2	+	6	2049	c.1631G>A	c.(1630-1632)cGg>cAg	p.R544Q	NWD1_ENST00000523826.1_Missense_Mutation_p.R338Q|NWD1_ENST00000379808.3_Missense_Mutation_p.R544Q|NWD1_ENST00000552788.1_Missense_Mutation_p.R544Q|NWD1_ENST00000339803.6_Missense_Mutation_p.R409Q|NWD1_ENST00000549814.1_Missense_Mutation_p.R544Q	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	544	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAGGAAGCCCGGAAATGGGCC	0.662000													18	43					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35579437	35579437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35579437C>T	ENST00000373330.1	+	11	2180	c.2006C>T	c.(2005-2007)tCa>tTa	p.S669L	ZMYM1_ENST00000359858.4_Missense_Mutation_p.S669L|ZMYM1_ENST00000373329.1_3'UTR			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	669						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCACAAAAATCATCAAAGGCT	0.368000													21	51					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99724046	99724046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:99724046C>T	ENST00000345514.2	-	2	455	c.189G>A	c.(187-189)atG>atA	p.M63I	BCL11B_ENST00000357195.3_Missense_Mutation_p.M63I|BCL11B_ENST00000443726.2_Intron	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	0						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		AGGGGAAGTTCATTTGACACT	0.577000			T	TLX3	T-ALL								27	56					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104174648	104174648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104174648C>T	ENST00000020673.5	-	4	1622	c.1096G>A	c.(1096-1098)Gag>Aag	p.E366K	PSD_ENST00000406432.1_Missense_Mutation_p.E366K	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	366					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TCAAACACCTCGTCGTCCACA	0.657000													36	91					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10265791	10265791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10265791G>A	ENST00000418404.3	-	3	397	c.234C>T	c.(232-234)ttC>ttT	p.F78F	MYH13_ENST00000570743.1_Silent_p.F78F|MYH13_ENST00000252172.4_Silent_p.F78F			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	78	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GGTTCATGGGGAAGACCTGGT	0.483000													47	83					0	0	1	0	0
USP45	85015	broad.mit.edu	37	6	99885165	99885165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:99885165G>A	ENST00000327681.6	-	17	2803	c.2271C>T	c.(2269-2271)tcC>tcT	p.S757S	USP45_ENST00000500704.2_Silent_p.S757S|USP45_ENST00000539675.1_Silent_p.S50S|USP45_ENST00000369233.2_Silent_p.S709S|USP45_ENST00000392738.2_Silent_p.S437S	NM_001080481.1	NP_001073950.1	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	757					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(2)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	22		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		ATAATTTCCTGGAGGGTGTTC	0.388000													18	62					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59190271	59190271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59190271C>T	ENST00000302040.4	-	1	178	c.156G>A	c.(154-156)atG>atA	p.M52I		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						GGTGAGAGTCCATCTTAATGA	0.488000													11	82					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594940	179594940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179594940C>T	ENST00000589042.1	-	62	18411	c.18187G>A	c.(18187-18189)Gat>Aat	p.D6063N	TTN_ENST00000342992.6_Missense_Mutation_p.D4819N|TTN_ENST00000591111.1_Missense_Mutation_p.D5746N|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5746	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGTGTCATCCTTCCAAACT	0.468000													18	25					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135073590	135073590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135073590C>T	ENST00000393229.3	+	3	1227	c.451C>T	c.(451-453)Ctg>Ttg	p.L151L	NTNG2_ENST00000372179.3_Silent_p.L151L|NTNG2_ENST00000393228.4_Silent_p.L151L|NTNG2_ENST00000360670.3_Silent_p.L151L	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	151	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GGTCATGGTCCTGGAGAAGTC	0.652000													14	39					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56140524	56140524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56140524C>T	ENST00000319441.4	+	10	1697	c.1533C>T	c.(1531-1533)atC>atT	p.I511I	PCK1_ENST00000543666.1_Silent_p.I194I|PCK1_ENST00000535860.1_3'UTR	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	511					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TGCCCAAGATCTTCCATGTCA	0.562000													19	58					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82940393	82940393	+	Silent	SNP	G	G	A	rs113269048	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82940393G>A	ENST00000274341.4	-	4	1414	c.564C>T	c.(562-564)atC>atT	p.I188I		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	188	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CGAAGGAGGCGATCACAGCAT	0.582000													16	45					0	0	1	0	0
VLDLR	7436	broad.mit.edu	37	9	2646354	2646354	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:2646354T>C	ENST00000382100.2	+	11	1861	c.1505T>C	c.(1504-1506)gTt>gCt	p.V502A	VLDLR_ENST00000478776.1_3'UTR|VLDLR_ENST00000382099.2_Missense_Mutation_p.V502A	NM_003383.3	NP_003374.3	P98155	VLDLR_HUMAN	very low density lipoprotein receptor	502					cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		GATGACAAGGTTGGTAGACAT	0.393000													35	45					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130832813	130832813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130832813C>T	ENST00000357462.5	-	15	2325	c.2232G>A	c.(2230-2232)atG>atA	p.M744I	POTEF_ENST00000409914.2_Missense_Mutation_p.M744I			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	744	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GCATGCCCCCCATCATGCCCT	0.622000													39	77					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17017874	17017874	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17017874G>A	ENST00000443236.1	-	30	4087	c.4056C>T	c.(4054-4056)ccC>ccT	p.P1352P		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1305						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CCATGGCCAGGGGCGCAGCAG	0.662000													8	18					0	0	1	0	0
KRT77	374454	broad.mit.edu	37	12	53097069	53097069	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53097069C>T	ENST00000341809.3	-	1	178	c.150G>A	c.(148-150)ggG>ggA	p.G50G	KRT77_ENST00000537195.1_5'UTR	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	50	Head.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TTCCATGGATCCCATATCCAC	0.547000													19	42					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68250149	68250149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:68250149G>A	ENST00000347230.4	-	21	3858	c.3720C>T	c.(3718-3720)tcC>tcT	p.S1240S	ZFYVE26_ENST00000555452.1_Silent_p.S1240S	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1240					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GGCTTTGCCGGGATGAGCAAA	0.592000													40	69					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247751996	247751996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247751996C>T	ENST00000320065.1	+	1	335	c.335C>T	c.(334-336)tCc>tTc	p.S112F	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCCCTGGGATCCACTGAGTGC	0.522000													50	129					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196801382	196801382	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196801382G>A	ENST00000312428.6	-	20	3313	c.3213C>T	c.(3211-3213)ttC>ttT	p.F1071F		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1071	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACAAAAAAAAGAATCTGGGGA	0.328000													26	53					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49362255	49362255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49362255G>A	ENST00000263265.6	-	8	1389	c.834C>T	c.(832-834)gtC>gtT	p.V278V	PLEKHA4_ENST00000596713.1_5'UTR|PLEKHA4_ENST00000355496.5_Silent_p.V278V	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	278	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GAGGAGGTCGGACATCAATGC	0.706000													11	30					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97082625	97082625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:97082625C>T	ENST00000335456.7	-	6	1208	c.1188G>A	c.(1186-1188)ggG>ggA	p.G396G	NUTM2F_ENST00000253262.4_Silent_p.G411G|NUTM2F_ENST00000341207.4_Silent_p.G396G					NUT family member 2F																		CCCCTGTGTCCCCAGGGTGAG	0.622000													11	97					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79364271	79364271	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79364271C>T	ENST00000444841.1	-	0	285																											CATCTCATATCAGCCACTGAA	0.507000													5	13					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176740250	176740250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176740250C>T	ENST00000367662.3	+	17	5813	c.4649C>T	c.(4648-4650)aCc>aTc	p.T1550I		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1550	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GACGTGGGCACCATCTGCAAA	0.488000													24	50					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125148925	125148925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125148925G>A	ENST00000362012.2	+	9	1215	c.1210G>A	c.(1210-1212)Gag>Aag	p.E404K	PTGS1_ENST00000223423.4_Intron|PTGS1_ENST00000540753.1_Intron|AL162424.1_ENST00000600713.1_Missense_Mutation_p.R2C|PTGS1_ENST00000373698.5_Missense_Mutation_p.E295K	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	404					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity	p.E404K(1)		large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	GTACAGCTACGAGCAGTTCTT	0.577000													26	106					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36035837	36035837	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36035837C>T	ENST00000282507.3	-	7	1636	c.1535G>A	c.(1534-1536)tGg>tAg	p.W512*	UGT3A2_ENST00000513300.1_Nonsense_Mutation_p.W478*|UGT3A2_ENST00000545528.1_Nonsense_Mutation_p.W210*	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	512						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACGCAGCCACCAGACAGCCAT	0.587000													14	53					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15789950	15789950	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15789950C>T	ENST00000359621.4	+	5	451	c.426C>T	c.(424-426)ctC>ctT	p.L142L		NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	142	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						TGGCCTGCCTCCCTCCTGCCG	0.627000													40	72					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53225195	53225195	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53225195C>T	ENST00000330553.5	-	2	727	c.693G>A	c.(691-693)aaG>aaA	p.K231K		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	231	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CTCACTTGTTCTTGAAGTCCT	0.642000													35	107					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220480833	220480833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220480833C>T	ENST00000456909.1	+	25	3275	c.3185C>T	c.(3184-3186)gCc>gTc	p.A1062V	STK11IP_ENST00000295641.10_Missense_Mutation_p.A1073V			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	1073					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCCTGCTTGCCTGGATCCGG	0.622000													5	24					0	0	1	0	0
FOXJ1	2302	broad.mit.edu	37	17	74133578	74133578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74133578C>T	ENST00000322957.6	-	3	1476	c.1122G>A	c.(1120-1122)gaG>gaA	p.E374E		NM_001454.3	NP_001445.2	Q92949	FOXJ1_HUMAN	forkhead box J1	374					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|liver(1)|pancreas(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(166;0.187)			CCAGGAAGGTCTCATCGAAGT	0.682000													4	3					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389662	20389662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20389662G>A	ENST00000315915.4	+	1	922	c.897G>A	c.(895-897)agG>agA	p.R299R		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGCCGTAAGGAAAATTGTGA	0.383000													46	111					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38493843	38493843	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38493843G>A	ENST00000263409.4	-	14	2092	c.1930C>T	c.(1930-1932)Ctc>Ttc	p.L644F	LIFR_ENST00000503088.1_5'UTR|LIFR_ENST00000453190.2_Missense_Mutation_p.L644F	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	644	Fibronectin type-III 5.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					CAGGTGAGGAGAATCCCCTTT	0.413000			T	PLAG1	salivary adenoma								28	84					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151400505	151400505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151400505G>A	ENST00000271715.2	-	7	1186	c.872C>T	c.(871-873)cCc>cTc	p.P291L	POGZ_ENST00000491586.1_Missense_Mutation_p.P238L|POGZ_ENST00000409503.1_Intron|POGZ_ENST00000531094.1_Intron|POGZ_ENST00000361398.3_Missense_Mutation_p.P238L|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000392723.1_Missense_Mutation_p.P238L|POGZ_ENST00000368863.2_Missense_Mutation_p.P196L	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	291					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGGTGGAGAGGGGAAGGAGGG	0.517000													21	82					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48697087	48697087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48697087C>T	ENST00000354983.4	+	32	6095	c.5723C>T	c.(5722-5724)tCc>tTc	p.S1908F	CACNA1G_ENST00000514717.1_Intron|CACNA1G_ENST00000515765.1_Missense_Mutation_p.S1931F|CACNA1G_ENST00000510366.1_Intron|CACNA1G_ENST00000512389.1_Intron|CACNA1G_ENST00000513964.1_Intron|CACNA1G_ENST00000513689.2_Missense_Mutation_p.S1897F|CACNA1G_ENST00000507609.1_Intron|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000507336.1_Missense_Mutation_p.S1931F|CACNA1G_ENST00000507510.2_Missense_Mutation_p.S1942F|CACNA1G_ENST00000442258.2_Intron|CACNA1G_ENST00000514181.1_Intron|CACNA1G_ENST00000429973.2_Intron|CACNA1G_ENST00000352832.5_Intron|CACNA1G_ENST00000514079.1_Intron|CACNA1G_ENST00000515165.1_Intron|CACNA1G_ENST00000510115.1_Missense_Mutation_p.S1908F|CACNA1G_ENST00000503485.1_Intron|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000502264.1_Intron|CACNA1G_ENST00000359106.5_Missense_Mutation_p.S1942F|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000515411.1_Missense_Mutation_p.S1924F|CACNA1G_ENST00000360761.4_Intron	NM_198396.2	NP_938406.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1942					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	ATCCAGGGCTCCCTGGAGTGG	0.682000													4	18					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94888394	94888394	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94888394G>A	ENST00000357742.4	+	7	1005		c.e7+1		MCTP2_ENST00000543482.1_Splice_Site|MCTP2_ENST00000451018.3_Splice_Site|MCTP2_ENST00000331706.4_Splice_Site	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TGCCAGCAAGGTAAATATACT	0.338000													8	55					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4967979	4967979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4967979G>A	ENST00000380373.2	-	1	377	c.352C>T	c.(352-354)Ctg>Ttg	p.L118L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACATGATCAGGAGGACTGAG	0.443000													48	288					0	0	1	0	0
STXBP3	6814	broad.mit.edu	37	1	109302685	109302685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109302685C>T	ENST00000370008.3	+	6	466	c.416C>T	c.(415-417)tCc>tTc	p.S139F	STXBP3_ENST00000485167.1_3'UTR	NM_007269.2	NP_009200.2	O00186	STXB3_HUMAN	syntaxin binding protein 3	139	Mediates interaction with DOC2B (By similarity).				negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(3)|urinary_tract(1)	13		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		ATAAATATTTCCTTCATTCCA	0.289000													55	148					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74729435	74729435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:74729435C>T	ENST00000308807.7	-	2	684	c.221G>A	c.(220-222)gGg>gAg	p.G74E	MLKL_ENST00000306247.7_Missense_Mutation_p.G74E	NM_152649.2	NP_689862.1	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like	74							ATP binding|protein binding|protein kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(6)|skin(1)|stomach(2)	19						TTCTATCTCCCCATTAGCCTC	0.498000													14	104					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70048889	70048889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70048889G>A	ENST00000330891.5	-	10	2031	c.1805C>T	c.(1804-1806)tCc>tTc	p.S602F	BEST3_ENST00000488961.1_Missense_Mutation_p.S389F|BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Missense_Mutation_p.S496F	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	602						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GTTTCCCAGGGAAGTGTGGCT	0.498000													24	37					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58149057	58149057	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58149057G>A	ENST00000295956.4	+	43	7363	c.7198_splice	c.e43+1	p.G2400_splice	FLNB_ENST00000493452.1_Splice_Site_p.G2207_splice|FLNB_ENST00000490882.1_Splice_Site_p.G2431_splice|FLNB_ENST00000429972.2_Splice_Site_p.G2389_splice|FLNB_ENST00000419752.2_Splice_Site_p.G2220_splice|FLNB_ENST00000348383.5_Splice_Site_p.G2359_splice|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000358537.3_Splice_Site_p.G2376_splice|FLNB-AS1_ENST00000488720.1_RNA	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2400	Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGGCACCACAGGTAACCCACT	0.572000													21	37					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072209	17072209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17072209C>T	ENST00000359963.3	-	1	1491	c.1232G>A	c.(1231-1233)gGa>gAa	p.G411E		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	411					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GGCCCCAGCTCCTGGAATCAG	0.562000													28	54					0	0	1	0	0
TMEM155	132332	broad.mit.edu	37	4	122682721	122682721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122682721G>A	ENST00000337677.5	-	5	742	c.184C>T	c.(184-186)Cgc>Tgc	p.R62C	TMEM155_ENST00000394394.1_Missense_Mutation_p.R62C|TMEM155_ENST00000394396.1_Missense_Mutation_p.R62C	NM_152399.2	NP_689612.2	Q4W5P6	TM155_HUMAN	transmembrane protein 155	62						extracellular region				breast(1)|lung(5)	6						CCCTGCAAGCGAACCAAAAAC	0.378000													21	59					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6639129	6639129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6639129C>T	ENST00000333172.6	+	6	2204	c.2011C>T	c.(2011-2013)Cac>Tac	p.H671Y	TAS1R1_ENST00000351136.3_Missense_Mutation_p.H417Y|TAS1R1_ENST00000328191.4_3'UTR	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	671					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TACATTCTACCACGCCTGGGT	0.517000													23	112					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875172	247875172	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247875172C>T	ENST00000302084.2	-	1	933	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E296K(1)		breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCTCTTACTTCCTTATTACGA	0.428000													61	148					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74825433	74825433	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74825433G>A	ENST00000256362.4	+	2	2188	c.1947G>A	c.(1945-1947)acG>acA	p.T649T		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	649					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TCGCTACCACGAAGTTCAAGG	0.612000													22	51					0	0	1	0	0
FOXRED1	55572	broad.mit.edu	37	11	126143269	126143269	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:126143269C>T	ENST00000263578.5	+	4	530	c.456C>T	c.(454-456)ctC>ctT	p.L152L	FOXRED1_ENST00000442061.2_5'UTR|FOXRED1_ENST00000532125.1_Silent_p.L138L|FOXRED1_ENST00000534011.1_3'UTR	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	152						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		CCCTGGACCTCCGGTTCAACC	0.557000													31	120					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2573002	2573002	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2573002C>T	ENST00000358864.1	+	8	896	c.881C>T	c.(880-882)cCt>cTt	p.P294L		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	294						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						AAGACAGTGCCTCGGGCTGAG	0.438000													17	142					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	40034005	40034005	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40034005C>T	ENST00000350221.3	-	6	865		c.e6+1		FSIP1_ENST00000559692.1_Splice_Site	NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1											NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TTTAAATATACCTTTATTGAG	0.328000													13	31					0	0	1	0	0
FILIP1L	11259	broad.mit.edu	37	3	99568383	99568383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:99568383C>T	ENST00000331335.5	-	5	2607	c.2137G>A	c.(2137-2139)Ggg>Agg	p.G713R	CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000354552.3_Missense_Mutation_p.G713R|FILIP1L_ENST00000476723.1_Intron|FILIP1L_ENST00000487087.1_Missense_Mutation_p.G289R|FILIP1L_ENST00000471562.1_Missense_Mutation_p.G473R|FILIP1L_ENST00000383694.2_Missense_Mutation_p.G473R|CMSS1_ENST00000496116.1_Intron	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	713						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						GAGAGGTGCCCTGACTTAGCT	0.408000													11	144					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703632	4703632	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4703632G>A	ENST00000396950.3	-	2	549	c.310C>T	c.(310-312)Cat>Tat	p.H104Y		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GAGAGGGCATGAATAAAGAAC	0.517000													17	46					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72005678	72005678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72005678G>A	ENST00000294053.3	-	14	1809	c.1636C>T	c.(1636-1638)Cgc>Tgc	p.R546C	CLPB_ENST00000340729.5_Missense_Mutation_p.R487C|CLPB_ENST00000538021.1_Missense_Mutation_p.R154C|CLPB_ENST00000543042.1_Missense_Mutation_p.R345C|CLPB_ENST00000538039.1_Missense_Mutation_p.R516C|CLPB_ENST00000437826.2_Missense_Mutation_p.R501C	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	546					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						AGGATAGGGCGAATCACATTC	0.468000													48	120					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120197765	120197765	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120197765G>A	ENST00000019103.5	-	13	1518	c.1251C>T	c.(1249-1251)gcC>gcT	p.A417A		NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	417					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	TGCTGAAGGAGGCCACGGGGT	0.637000													5	25					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169511239	169511239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169511239C>T	ENST00000367796.3	-	13	3305	c.3104G>A	c.(3103-3105)cGa>cAa	p.R1035Q	F5_ENST00000367797.3_Missense_Mutation_p.R1030Q			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1030	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTTCTTTTTTCGTGTCTTAAT	0.408000													114	243					0	0	1	0	0
XRN2	22803	broad.mit.edu	37	20	21314251	21314251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:21314251C>T	ENST00000377191.3	+	10	1023	c.928C>T	c.(928-930)Cgt>Tgt	p.R310C	XRN2_ENST00000430571.2_Missense_Mutation_p.R234C|XRN2_ENST00000539513.1_Missense_Mutation_p.R256C	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	310					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						TAATGTTCTTCGTGAGGTATG	0.403000													66	165					0	0	1	0	0
CIB3	117286	broad.mit.edu	37	19	16280507	16280507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16280507G>A	ENST00000269878.4	-	3	181	c.132C>T	c.(130-132)ctC>ctT	p.L44L	CIB3_ENST00000541493.1_Intron|CIB3_ENST00000379859.3_Intron	NM_054113.2	NP_473454.1	Q96Q77	CIB3_HUMAN	calcium and integrin binding family member 3	44							calcium ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16						TGGTATAGTCGAGGGGCACGA	0.587000													6	35					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93742422	93742422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:93742422C>T	ENST00000265990.6	+	18	2435	c.2127C>T	c.(2125-2127)tcC>tcT	p.S709S	BTAF1_ENST00000471217.1_3'UTR	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	709					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				CAGCTGAATCCCTGGGCCAGT	0.408000													34	84					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114292282	114292282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:114292282G>A	ENST00000393500.3	+	15	1714	c.894G>A	c.(892-894)ttG>ttA	p.L298L	FOXP2_ENST00000390668.3_Silent_p.L397L|FOXP2_ENST00000403559.4_Silent_p.L390L|FOXP2_ENST00000393494.2_Silent_p.L373L|FOXP2_ENST00000393498.2_Silent_p.L352L|FOXP2_ENST00000360232.4_Silent_p.L373L|FOXP2_ENST00000408937.3_Silent_p.L398L|FOXP2_ENST00000393489.3_Silent_p.L281L|FOXP2_ENST00000393491.3_Silent_p.L281L|FOXP2_ENST00000350908.4_Silent_p.L373L			O15409	FOXP2_HUMAN	forkhead box P2	373				DLTTNNSSSTTSSNT -> EEFPVQGPAAVCAGL (in Ref. 10; AAB91439).	camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						AACACGCATTGGATGACCGAA	0.408000													11	59					0	0	1	0	0
TOP1MT	116447	broad.mit.edu	37	8	144416946	144416946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144416946G>A	ENST00000329245.4	-	1	120	c.86C>T	c.(85-87)cCg>cTg	p.P29L	TOP1MT_ENST00000523676.1_5'UTR|TOP1MT_ENST00000521193.1_Intron|TOP1MT_ENST00000519148.1_Intron	NM_052963.2	NP_443195.1	Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	29					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	GCGCGAGCCCGGGACACCCCG	0.741000													8	33					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24171030	24171030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24171030G>A	ENST00000265769.4	+	6	623	c.513G>A	c.(511-513)atG>atA	p.M171I	ADAM28_ENST00000437154.2_Missense_Mutation_p.M171I|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_Intron|RP11-624C23.1_ENST00000523578.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	171					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CCTGTGGGATGGATGGTGTGT	0.433000													39	142					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79343150	79343150	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79343150C>T	ENST00000264895.6	+	34	5114	c.4674C>T	c.(4672-4674)ttC>ttT	p.F1558F	FRAS1_ENST00000325942.6_Silent_p.F1558F	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1557					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CCTTCTCGTTCGCTGGTAATG	0.567000													51	124					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107034	121107034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:121107034G>A	ENST00000295228.3	+	2	854	c.808G>A	c.(808-810)Gag>Aag	p.E270K		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	270					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				CCCAGGCGAAGAGTCGCACCG	0.672000													36	81					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414089	20414089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:20414089G>A	ENST00000380338.4	-	5	1041	c.755C>T	c.(754-756)gCc>gTc	p.A252V	MLLT3_ENST00000429426.2_Missense_Mutation_p.A249V|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TTCCTTGAAGGCCATCTTAGG	0.403000			T	MLL	ALL								108	211					0	0	1	0	0
PA2G4	5036	broad.mit.edu	37	12	56504387	56504387	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56504387C>T	ENST00000303305.6	+	9	1172	c.753C>T	c.(751-753)ccC>ccT	p.P251P	RP11-603J24.17_ENST00000548595.1_RNA|PA2G4_ENST00000552766.1_Silent_p.P251P	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	251					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AACGAGACCCCTCTAAACAGT	0.433000													29	66					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51981872	51981872	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51981872C>T	ENST00000451626.1	+	2	159	c.159C>T	c.(157-159)ctC>ctT	p.L53L				A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	53						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGGGACCCCTCCTCCTGGAGG	0.627000													4	21					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10419894	10419894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10419894C>T	ENST00000226207.5	-	3	160	c.66G>A	c.(64-66)agG>agA	p.R22R	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	22	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CAATTCGCTCCCTTTCAGACT	0.507000													45	88					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15990197	15990197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15990197C>T	ENST00000221700.5	-	12	1451	c.1356G>A	c.(1354-1356)gaG>gaA	p.E452E	CYP4F2_ENST00000592328.1_Silent_p.E452E	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	452					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GAGGTGACCTCTCCTTGATGT	0.602000													65	186					0	0	1	0	0
KPTN	11133	broad.mit.edu	37	19	47986450	47986450	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47986450G>A	ENST00000338134.3	-	4	524	c.417C>T	c.(415-417)ctC>ctT	p.L139L	KPTN_ENST00000536339.1_5'UTR|KPTN_ENST00000595484.1_5'UTR	NM_007059.2	NP_008990.2	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	139					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			breast(1)|lung(3)|ovary(2)|pancreas(2)	8		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		GAGTGAACTGGAGCTCCAGGT	0.612000													81	177					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49742868	49742868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:49742868C>T	ENST00000492622.2	+	10	1462	c.1157C>T	c.(1156-1158)tCa>tTa	p.S386L	FNDC3A_ENST00000541916.1_Missense_Mutation_p.S386L|FNDC3A_ENST00000398316.3_Missense_Mutation_p.S330L	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	386	Fibronectin type-III 2.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ACCAAAAATTCACTCACTTTG	0.398000													55	156					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106704939	106704939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:106704939C>T	ENST00000546625.1	+	2	245	c.86C>T	c.(85-87)tCg>tTg	p.S29L	TCP11L2_ENST00000299045.3_Missense_Mutation_p.S29L|TCP11L2_ENST00000547153.1_Missense_Mutation_p.S29L			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	29	Ser-rich.									endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						AGCATGGCTTCGCTCAGTGAC	0.542000													7	83					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102711167	102711167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102711167G>A	ENST00000299855.5	-	5	1039	c.783C>T	c.(781-783)tcC>tcT	p.S261S		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	261					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CACCATAGAGGGACTGAATGC	0.418000													35	67					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188210	32188210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32188210G>A	ENST00000375023.3	-	6	1269	c.1131C>T	c.(1129-1131)ttC>ttT	p.F377F		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	377	EGF-like 9; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity	p.F377L(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						AGAGGCAGGAGAAAGAGCCCA	0.607000													37	136					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90024714	90024714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90024714G>A	ENST00000405460.2	+	49	10486	c.10390G>A	c.(10390-10392)Gat>Aat	p.D3464N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3464					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTCAGCCAATGATATTTACCT	0.353000													15	28					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719696	140719696	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140719696C>T	ENST00000394576.2	+	1	1158	c.1158C>T	c.(1156-1158)ctC>ctT	p.L386L	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGTTCACTCCCCGAGGATC	0.433000													40	92					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446685	10446685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:10446685G>A	ENST00000326756.3	-	3	1706	c.1268C>T	c.(1267-1269)cCt>cTt	p.P423L		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						CTGAACTGAAGGTTGAAAACT	0.343000													57	129					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109629448	109629448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109629448C>T	ENST00000338432.7	+	14	2294	c.2175C>T	c.(2173-2175)tcC>tcT	p.S725S	ACACB_ENST00000377848.3_Silent_p.S725S|ACACB_ENST00000377854.5_Silent_p.S725S			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	725	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGGAACTGTCCATCCGAGGCG	0.488000													16	82					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3784165	3784165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3784165C>T	ENST00000310132.6	-	5	717	c.319G>A	c.(319-321)Gag>Aag	p.E107K	MATK_ENST00000585778.1_Missense_Mutation_p.E107K|MATK_ENST00000395045.2_Missense_Mutation_p.E108K|MATK_ENST00000395040.2_Missense_Mutation_p.E66K	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	107	SH3.			ER -> DG (in Ref. 1; AAA16703).	cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCCCGCTCCCGCAGCGCC	0.677000													17	56					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432962	104432962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104432962C>T	ENST00000361820.3	-	3	2332	c.1732G>A	c.(1732-1734)Gga>Aga	p.G578R		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	578					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ATGCAATATCCATAGCAGCAC	0.418000													37	51					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68115441	68115441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68115441C>T	ENST00000294304.7	+	2	324	c.218C>T	c.(217-219)tCc>tTc	p.S73F		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	73	Beta-propeller 1.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTCCAGTTTTCCAAGGGAGCC	0.657000													24	101					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136320692	136320692	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136320692C>T	ENST00000371929.3	+	25	3979	c.3535C>T	c.(3535-3537)Ctg>Ttg	p.L1179L	ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000356589.2_Intron|ADAMTS13_ENST00000485925.1_Intron|ADAMTS13_ENST00000355699.2_Intron	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	1179					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TCGGCGGCTCCTGCCCGGGCC	0.672000													23	77					0	0	1	0	0
KDM1B	221656	broad.mit.edu	37	6	18160191	18160191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:18160191C>T	ENST00000388870.2	+	3	306	c.65C>T	c.(64-66)cCt>cTt	p.P22L	KDM1B_ENST00000546309.2_Intron|KDM1B_ENST00000397244.1_Missense_Mutation_p.P22L|KDM1B_ENST00000297792.5_Missense_Mutation_p.P22L			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	22					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						GATAGCCTTCCTTTGAGGAGC	0.403000													16	32					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160853249	160853249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160853249C>T	ENST00000326245.3	-	3	241	c.126G>A	c.(124-126)aaG>aaA	p.K42K		NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	42	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTTTGATTTCCTTGCAGCTTC	0.443000													37	119					0	0	1	0	0
AMDHD1	144193	broad.mit.edu	37	12	96354255	96354255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:96354255G>A	ENST00000266736.2	+	5	773	c.667G>A	c.(667-669)Gaa>Aaa	p.E223K		NM_152435.2	NP_689648.2	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	223					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|skin(1)	22						CAGAAATGGGGAAATACACGT	0.418000													9	83					0	0	1	0	0
ATP5F1	515	broad.mit.edu	37	1	111996918	111996918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111996918C>T	ENST00000369722.3	+	3	769	c.163C>T	c.(163-165)Cgt>Tgt	p.R55C	ATP5F1_ENST00000369721.4_Intron|ATP5F1_ENST00000483994.1_Intron	NM_001688.4	NP_001679.2	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1	55					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding	p.R55C(1)		breast(1)|cervix(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGGAAAAGTTCGTTATGGACT	0.438000													50	97					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566094	136566094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136566094C>T	ENST00000264162.2	-	8	3833	c.3823G>A	c.(3823-3825)Gga>Aga	p.G1275R		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1275	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGCCCCACTCCGTTTTCGGTG	0.502000													75	169					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160869799	160869799	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160869799G>A	ENST00000283243.7	-	10	1845	c.1639C>T	c.(1639-1641)Cct>Tct	p.P547S	PLA2R1_ENST00000392771.1_Missense_Mutation_p.P547S	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	547	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						ACAAGTGCAGGAGGACAGTAA	0.383000													19	56					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1422039	1422039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1422039G>A	ENST00000270349.9	-	5	871	c.744C>T	c.(742-744)atC>atT	p.I248I	SLC6A3_ENST00000453492.2_Silent_p.I248I	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	248					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGAGCAGCACGATGACCAGCA	0.647000													26	90					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95557267	95557267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95557267G>A	ENST00000371418.4	+	8	1641	c.1381G>A	c.(1381-1383)Gga>Aga	p.G461R	LGI1_ENST00000371413.3_Intron|LGI1_ENST00000542308.1_Missense_Mutation_p.G413R	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	461					axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				CATGAAATGGGGAGGCTCCTC	0.443000													21	72					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226549171	226549171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226549171G>A	ENST00000366794.5	-	23	3178	c.3035C>T	c.(3034-3036)tCc>tTc	p.S1012F	PARP1_ENST00000490921.1_5'UTR	NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	1012	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TTACCACAGGGAGGTCTTAAA	0.478000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					5	38					0	0	1	0	0
EDDM3B	64184	broad.mit.edu	37	14	21238679	21238679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21238679G>A	ENST00000326783.3	+	2	468	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K		NM_022360.4	NP_071755.1	P56851	EP3B_HUMAN	epididymal protein 3B	124					spermatid development	extracellular region				central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						CAACTACATTGAATTCCATTG	0.413000													12	93					0	0	1	0	0
ALPL	249	broad.mit.edu	37	1	21903920	21903920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21903920G>A	ENST00000374840.3	+	12	1604	c.1354G>A	c.(1354-1356)Gag>Aag	p.E452K	ALPL_ENST00000539907.1_Missense_Mutation_p.E375K|ALPL_ENST00000540617.1_Missense_Mutation_p.E397K|ALPL_ENST00000374829.1_Missense_Mutation_p.E98K|ALPL_ENST00000425315.2_Missense_Mutation_p.E452K|ALPL_ENST00000374830.1_Missense_Mutation_p.E98K|ALPL_ENST00000374832.1_Missense_Mutation_p.E452K	NM_000478.4	NP_000469.3	P05186	PPBT_HUMAN	alkaline phosphatase, liver/bone/kidney	452			E -> K (in HOPS).		response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	26		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	CCTGCGCCACGAGACCCACGG	0.687000													26	38					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143057231	143057231	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143057231T>A	ENST00000443739.2	-	2	188	c.40A>T	c.(40-42)Att>Ttt	p.I14F	FAM131B_ENST00000409578.1_Missense_Mutation_p.I14F|FAM131B_ENST00000409222.3_5'UTR|FAM131B_ENST00000409408.1_5'UTR|FAM131B_ENST00000409346.1_5'UTR	NM_001031690.2|NM_001278297.1	NP_001026860.2|NP_001265226.1	Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	0										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					TCCACTGCAATCACCTCATTC	0.617000													7	20					0	0	1	0	0
DDX31	64794	broad.mit.edu	37	9	135487632	135487632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135487632G>A	ENST00000372159.3	-	19	2302	c.2151C>T	c.(2149-2151)tcC>tcT	p.S717S	DDX31_ENST00000372153.1_Silent_p.S644S|DDX31_ENST00000438527.3_Silent_p.S588S	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	717						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		CTTGGATGAAGGACTGCAGAG	0.562000													9	54					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124181467	124181467	+	Missense_Mutation	SNP	G	G	A	rs139954729	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124181467G>A	ENST00000360013.3	+	25	4139	c.4012G>A	c.(4012-4014)Gat>Aat	p.D1338N	KALRN_ENST00000240874.3_Missense_Mutation_p.D1338N|KALRN_ENST00000460856.1_Missense_Mutation_p.D1329N	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1338	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGAGATCTACGATTTCCATAA	0.483000													10	40					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98288962	98288962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:98288962C>T	ENST00000322128.3	-	1	1214	c.1111G>A	c.(1111-1113)Gaa>Aaa	p.E371K		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	371					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding	p.E371Q(1)		cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CACAATTCTTCGTTGATTATC	0.468000													63	216					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109840831	109840831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109840831C>T	ENST00000357155.1	-	2	243	c.194G>A	c.(193-195)cGg>cAg	p.R65Q	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	65	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CCCAACCTTCCGGATGTAGGT	0.522000													24	125					0	0	1	0	0
NR1H4	9971	broad.mit.edu	37	12	100926317	100926317	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100926317G>A	ENST00000548884.1	+	5	1068	c.527G>A	c.(526-528)cGa>cAa	p.R176Q	NR1H4_ENST00000551379.1_Missense_Mutation_p.R186Q|NR1H4_ENST00000392986.3_Missense_Mutation_p.R176Q|NR1H4_ENST00000188403.7_Missense_Mutation_p.R186Q|NR1H4_ENST00000549996.1_Intron	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	186					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						ATGTACATGCGAAGAAAGTGT	0.408000													28	75					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848369	123848369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123848369C>T	ENST00000531945.1	-	1	119	c.30G>A	c.(28-30)atG>atA	p.M10I		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTGTCATGGTCATCTTCTCAC	0.468000													44	81					0	0	1	0	0
SPN	6693	broad.mit.edu	37	16	29675707	29675707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29675707G>A	ENST00000360121.3	+	2	750	c.658G>A	c.(658-660)Gga>Aga	p.G220R	AC009133.19_ENST00000449759.1_Intron|SPN_ENST00000395389.2_Missense_Mutation_p.G220R	NM_001030288.2|NM_003123.4	NP_001025459.1|NP_003114.1	P16150	LEUK_HUMAN	sialophorin	220					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|stomach(1)	15						CGGGGCCAGTGGACCCCAGGT	0.567000													14	125					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201778347	201778347	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201778347C>T	ENST00000367296.4	+	21	4683	c.4263C>T	c.(4261-4263)ctC>ctT	p.L1421L	NAV1_ENST00000367300.3_Silent_p.L1361L|NAV1_ENST00000367297.4_Silent_p.L1413L|NAV1_ENST00000367295.1_Silent_p.L1027L|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000295624.6_Silent_p.L1418L|NAV1_ENST00000367302.1_Silent_p.L1374L	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1421					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						AAGTGACCCTCCGGGTGGTGG	0.512000													49	158					0	0	1	0	0
OR4F17	81099	broad.mit.edu	37	19	110706	110706	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:110706C>T	ENST00000585993.1	+	2	167	c.28C>T	c.(28-30)Ctc>Ttc	p.L10F	OR4F17_ENST00000318050.3_Missense_Mutation_p.L10F			Q8NGA8	O4F17_HUMAN	olfactory receptor, family 4, subfamily F, member 17	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(2)	2		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTTCTGGGTCTCTCTGATTC	0.393000													69	507					0	0	1	0	0
AKR1C3	8644	broad.mit.edu	37	10	5147850	5147850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5147850C>T	ENST00000380554.3	+	8	1562	c.910C>T	c.(910-912)Cac>Tac	p.H304Y	AKR1C3_ENST00000605149.1_Missense_Mutation_p.H281Y|AKR1C3_ENST00000439082.2_Missense_Mutation_p.H185Y	NM_001253908.1|NM_003739.5	NP_001240837.1|NP_003730.4	P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3	304					prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	CAGAAATCTCCACTATTTTAA	0.358000													13	35					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97920070	97920070	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97920070C>T	ENST00000534948.1	+	0	4848							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		GCGGCTTTTCCCTTTTAGTTC	0.393000													27	54					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117171115	117171115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117171115C>T	ENST00000003084.6	+	4	568	c.436C>T	c.(436-438)Cat>Tat	p.H146Y	CFTR_ENST00000454343.1_Missense_Mutation_p.H146Y	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	146	ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTTTGGCCTTCATCACATTGG	0.418000									Cystic Fibrosis				8	56					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103717	52103717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52103717G>A	ENST00000361781.2	-	7	1117	c.158C>T	c.(157-159)tCc>tTc	p.S53F	SGMS1_ENST00000361543.2_Missense_Mutation_p.S53F|SGMS1_ENST00000429490.1_Intron	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	59	SAM.				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						ATTGTCAGAGGAGACTCGGCA	0.517000													36	61					0	0	1	0	0
TRIM61	391712	broad.mit.edu	37	4	165891019	165891019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:165891019C>T	ENST00000329314.5	-	3	748	c.136G>A	c.(136-138)Gat>Aat	p.D46N		NM_001012414.2	NP_001012414.1	Q5EBN2	TRI61_HUMAN	tripartite motif containing 61	46						intracellular	zinc ion binding			NS(1)|kidney(1)|liver(1)|skin(1)|upper_aerodigestive_tract(1)	5	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.155)		TCATGTAGATCCTTCCAGGAC	0.463000													27	116					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6692287	6692287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6692287G>A	ENST00000309577.6	-	26	4300	c.4137C>T	c.(4135-4137)ctC>ctT	p.L1379L	CHD4_ENST00000544040.1_Intron|RP5-940J5.6_ENST00000501075.2_RNA|CHD4_ENST00000540960.1_Intron|CHD4_ENST00000544484.1_Silent_p.L1376L|CHD4_ENST00000357008.2_Intron			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1353					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						AATCTGGAGGGAGAGAGGGCA	0.607000													13	123					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18892399	18892399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18892399C>T	ENST00000380548.4	+	26	4995	c.4656C>T	c.(4654-4656)acC>acT	p.T1552T	ADAMTSL1_ENST00000380545.5_Silent_p.T253T	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1552	TSP type-1 8.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GGATGGTGACCTCCTGGTCTG	0.612000													6	10					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33234287	33234287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33234287C>T	ENST00000401073.2	+	4	567	c.497C>T	c.(496-498)tCc>tTc	p.S166F	KIAA1522_ENST00000294521.3_Missense_Mutation_p.S107F|KIAA1522_ENST00000373481.3_Missense_Mutation_p.S118F|KIAA1522_ENST00000373480.1_Missense_Mutation_p.S107F	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	107										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GACAACATCTCCTTCTGCAGT	0.562000													13	55					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71742858	71742858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71742858G>A	ENST00000258104.3	+	7	1046	c.769G>A	c.(769-771)Gga>Aga	p.G257R	DYSF_ENST00000410041.1_Missense_Mutation_p.G289R|DYSF_ENST00000429174.2_Missense_Mutation_p.G257R|DYSF_ENST00000409744.1_Missense_Mutation_p.G258R|DYSF_ENST00000410020.3_Missense_Mutation_p.G289R|DYSF_ENST00000394120.2_Missense_Mutation_p.G258R|DYSF_ENST00000409366.1_Missense_Mutation_p.G258R|DYSF_ENST00000409582.3_Missense_Mutation_p.G288R|DYSF_ENST00000413539.2_Missense_Mutation_p.G288R|DYSF_ENST00000409651.1_Missense_Mutation_p.G289R|DYSF_ENST00000409762.1_Missense_Mutation_p.G288R	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	257	C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GATCCACAAGGGAAACAGCCC	0.612000													17	54					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62286063	62286063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62286063G>A	ENST00000378024.4	-	5	16100	c.15826C>T	c.(15826-15828)Ccc>Tcc	p.P5276S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5276					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GAAACATCGGGCCCTTCGAGC	0.537000													20	71					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84473122	84473122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84473122C>T	ENST00000416219.2	+	13	1290	c.1201C>T	c.(1201-1203)Cgt>Tgt	p.R401C	ATP2C2_ENST00000262429.4_Missense_Mutation_p.R401C|ATP2C2_ENST00000420010.2_3'UTR			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	401					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						AGATGGGCTTCGTGCCGAGGT	0.493000													49	108					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7581370	7581370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7581370G>A	ENST00000379802.3	+	23	5288	c.4947G>A	c.(4945-4947)agG>agA	p.R1649R	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1649	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAAAGCAGAGGACCCAGGAAG	0.572000													35	73					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4153693	4153693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4153693G>A	ENST00000404826.2	+	25	3749	c.3610G>A	c.(3610-3612)Ggg>Agg	p.G1204R	SDK1_ENST00000389531.3_Missense_Mutation_p.G1204R	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1204	Fibronectin type-III 6.				cell adhesion	integral to membrane		p.G1204R(1)		NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCAGTACAACGGGAACCCCGA	0.587000													17	38					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049251	42049251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42049251G>A	ENST00000372584.1	-	3	2232	c.1218C>T	c.(1216-1218)ccC>ccT	p.P406P	HIVEP3_ENST00000429157.2_Silent_p.P406P|HIVEP3_ENST00000372583.1_Silent_p.P406P|HIVEP3_ENST00000247584.5_Silent_p.P406P	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	406	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Ser-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGTGTTTGGGGGGCTGACCT	0.592000													17	99					0	0	1	0	0
ZNF813	126017	broad.mit.edu	37	19	53994932	53994932	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53994932C>T	ENST00000396403.4	+	4	1574	c.1446C>T	c.(1444-1446)ctC>ctT	p.L482L	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	482					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TTTCAGCCCTCGTAATTCATA	0.403000													18	68					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20466293	20466293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:20466293C>T	ENST00000377252.3	+	9	1857	c.1016C>T	c.(1015-1017)tCt>tTt	p.S339F	PLXDC2_ENST00000377238.2_3'UTR|PLXDC2_ENST00000377242.3_Missense_Mutation_p.S290F	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	339	PSI.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						CCCTGTGTATCTTCTCAGATT	0.348000													47	133					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142569571	142569571	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142569571G>A	ENST00000359396.3	-	15	2312	c.2067C>T	c.(2065-2067)tcC>tcT	p.S689S		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	689					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					CACTGCTGCGGGAGGTACTTC	0.572000													12	54					0	0	1	0	0
CTD-2090I13.1	0	broad.mit.edu	37	1	227618340	227618340	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:227618340G>A	ENST00000445817.1	+	0	1575																											GCTGTGGGTCGAAGATATGCT	0.502000													15	51					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168845770	168845770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168845770G>A	ENST00000464456.1	-	4	1328	c.128C>T	c.(127-129)cCa>cTa	p.P43L	MECOM_ENST00000433243.2_Missense_Mutation_p.P43L|MECOM_ENST00000472280.1_Missense_Mutation_p.P43L|MECOM_ENST00000392736.3_Missense_Mutation_p.P43L|MECOM_ENST00000494292.1_Missense_Mutation_p.P231L|MECOM_ENST00000468789.1_Missense_Mutation_p.P43L|MECOM_ENST00000264674.3_Missense_Mutation_p.P107L|MECOM_ENST00000460814.1_Missense_Mutation_p.P43L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						AGTACTGCATGGAAACTTTTG	0.438000													59	147					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	782337	782337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:782337G>A	ENST00000540986.1	-	7	1989	c.554C>T	c.(553-555)tCc>tTc	p.S185F	NARFL_ENST00000251588.2_Missense_Mutation_p.S287F|NARFL_ENST00000562862.1_5'UTR|NARFL_ENST00000301694.5_3'UTR|NARFL_ENST00000568545.1_Missense_Mutation_p.S185F			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	287					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				GTCGGGGAGGGAGACGCCCTC	0.527000													65	156					0	0	1	0	0
RNF169	254225	broad.mit.edu	37	11	74500681	74500681	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74500681C>T	ENST00000299563.4	+	2	526	c.513C>T	c.(511-513)ttC>ttT	p.F171F		NM_001098638.1	NP_001092108.1	Q8NCN4	RN169_HUMAN	ring finger protein 169	171							zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	15						ACTTTATATTCAGAGCACCAA	0.343000													11	137					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37936686	37936686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37936686G>A	ENST00000199447.4	+	17	2131	c.1759G>A	c.(1759-1761)Gaa>Aaa	p.E587K	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.E587K	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	587	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										GGATCCTGAGGAAAACTAAAG	0.353000													14	41					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180566	124180566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124180566C>T	ENST00000357821.2	-	1	167	c.97G>A	c.(97-99)Gga>Aga	p.G33R		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ACATAGATTCCCAGGAACAGG	0.483000													45	106					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3779070	3779070	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3779070G>A	ENST00000310132.6	-	12	1515	c.1117C>T	c.(1117-1119)Ctg>Ttg	p.L373L	MATK_ENST00000585778.1_Silent_p.L373L|MATK_ENST00000395045.2_Silent_p.L374L|MATK_ENST00000395040.2_Silent_p.L332L	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	373	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTTGGCCAGGCCAAAGTCG	0.637000													10	30					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183777966	183777966	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183777966G>A	ENST00000318351.1	+	9	1204	c.1170G>A	c.(1168-1170)ggG>ggA	p.G390G		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	390						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGTTAGCAGGGAAGAAGCTGG	0.607000													13	36					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20490544	20490544	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20490544G>A	ENST00000555186.1	+	0	524					NR_038836.1																						TGGATCCAAAGGCATGTTTTA	0.438000													14	305					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503381	140503381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140503381C>T	ENST00000194152.1	+	1	1801	c.1801C>T	c.(1801-1803)Ctg>Ttg	p.L601L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		601	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAACGCCTGGCTGTCGTACCA	0.731000													39	89					0	0	1	0	0
SLC17A4	10050	broad.mit.edu	37	6	25769328	25769328	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25769328C>T	ENST00000377905.4	+	3	326	c.207C>T	c.(205-207)gcC>gcT	p.A69A	SLC17A4_ENST00000397076.2_Silent_p.A15A|SLC17A4_ENST00000439485.2_Silent_p.A69A	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	69					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ACAACACAGCCCCACCTAGCC	0.468000													27	80					0	0	1	0	0
YBX3	8531	broad.mit.edu	37	12	10856655	10856655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10856655G>A	ENST00000228251.4	-	7	1073	c.873C>T	c.(871-873)taC>taT	p.Y291Y	YBX3_ENST00000279550.7_Silent_p.Y222Y|YBX3_ENST00000546164.1_Intron	NM_003651.4	NP_003642.3			Y box binding protein 3																		CATACCTACGGTACCTTGGGC	0.478000													11	73					0	0	1	0	0
TRAV38-2DV8	28643	broad.mit.edu	37	14	22749540	22749540	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22749540G>A	ENST00000390465.2	+	0	304																											GTTTCTCTGTGAACTTCCAGA	0.468000													22	38					0	0	1	0	0
TRIM6	117854	broad.mit.edu	37	11	5625954	5625954	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5625954G>A	ENST00000507320.1	+	0	388				TRIM6_ENST00000445329.1_Intron|AC015691.13_ENST00000394793.2_RNA|TRIM6_ENST00000506134.1_Intron|TRIM6-TRIM34_ENST00000354852.5_Intron|TRIM6_ENST00000515022.1_Intron|TRIM6_ENST00000380097.3_Intron|TRIM6_ENST00000380107.1_Intron|TRIM6_ENST00000278302.5_Intron|HBG2_ENST00000380259.2_Intron					tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		TCTGTCCTCTGATGCCATGAC	0.488000													3	9					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502502	91502502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91502502G>A	ENST00000266718.4	-	2	709	c.255C>T	c.(253-255)gcC>gcT	p.A85A	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	85					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						CATTCTCAAAGGCCTTTTCAT	0.378000													21	45					0	0	1	0	0
HEXIM2	124790	broad.mit.edu	37	17	43246863	43246863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43246863G>A	ENST00000307275.3	+	4	984	c.548G>A	c.(547-549)cGa>cAa	p.R183Q	RP13-890H12.2_ENST00000589796.1_RNA|HEXIM2_ENST00000592695.1_Missense_Mutation_p.R183Q|HEXIM2_ENST00000591576.1_Missense_Mutation_p.R183Q	NM_144608.1	NP_653209.1	Q96MH2	HEXI2_HUMAN	hexamethylene bis-acetamide inducible 2	183					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			endometrium(1)|large_intestine(3)|lung(1)	5						GGGCGGGGCCGAGCGCACGGT	0.652000													9	9					0	0	1	0	0
NPIPB15	440348	broad.mit.edu	37	16	74425514	74425514	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:74425514C>A	ENST00000429990.1	+	7	964	c.868C>A	c.(868-870)Ctt>Att	p.L290I						nuclear pore complex interacting protein family, member B15																		TCTTGCTCCTCTTCCACCCTC	0.502000													21	311					2.65835e-16	2.67254e-16	1	1	0
UNC13A	23025	broad.mit.edu	37	19	17768936	17768936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17768936G>A	ENST00000428389.2	-	10	965	c.966C>T	c.(964-966)ggC>ggT	p.G322G	UNC13A_ENST00000551649.1_Silent_p.G234G|UNC13A_ENST00000552293.1_Silent_p.G234G|UNC13A_ENST00000252773.7_Silent_p.G234G|UNC13A_ENST00000519716.2_Silent_p.G234G|UNC13A_ENST00000550896.1_Silent_p.G234G			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	234	Glu-rich.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						ACTCCCGGGAGCCCAGGGGTG	0.582000													10	28					0	0	1	0	0
LIM2	3982	broad.mit.edu	37	19	51890686	51890686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51890686G>A	ENST00000221973.3	-	2	54	c.12C>T	c.(10-12)ttC>ttT	p.F4F	LIM2_ENST00000596399.1_Silent_p.F4F	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	4					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		CACCACCCATGAAGCTGTACA	0.607000													20	45					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35453185	35453185	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35453185G>A	ENST00000357182.4	-	16	3725	c.3498C>T	c.(3496-3498)ttC>ttT	p.F1166F	ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000373340.2_Intron|ZMYM6_ENST00000487874.1_Intron	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	1166					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AAAATGAAGggaacatgtcat	0.333000													17	38					0	0	1	0	0
LRP10	26020	broad.mit.edu	37	14	23344336	23344336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23344336C>T	ENST00000359591.4	+	4	979	c.288C>T	c.(286-288)tcC>tcT	p.S96S	LRP10_ENST00000546834.1_Silent_p.S96S	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	96	CUB 1.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		CACTGATCTCCCTGTGTGAGG	0.622000													13	49					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135975712	135975712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135975712G>A	ENST00000393160.3	-	17	2700	c.2347C>T	c.(2347-2349)Ctg>Ttg	p.L783L	RALGDS_ENST00000542690.1_Silent_p.L909L|RALGDS_ENST00000372050.3_Silent_p.L838L|RALGDS_ENST00000372062.3_Silent_p.L809L|RALGDS_ENST00000372047.3_Silent_p.L826L|RALGDS_ENST00000393157.3_Silent_p.L837L|RALGDS_ENST00000469972.1_5'UTR	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	838					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		TCCTCCTCCAGGTTGTGTTTG	0.597000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								122	200					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240637445	240637445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240637445G>A	ENST00000319653.9	+	18	5390	c.5160G>A	c.(5158-5160)atG>atA	p.M1720I	FMN2_ENST00000545751.1_Missense_Mutation_p.M316I|FMN2_ENST00000543681.1_Missense_Mutation_p.M40I|FMN2_ENST00000496950.1_3'UTR|AL646016.1_ENST00000596886.1_Intron	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1720					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AGATAAGCATGAAAACTTGAA	0.338000													7	32					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116605816	116605816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116605816C>T	ENST00000369248.4	+	9	1508	c.1173C>T	c.(1171-1173)ttC>ttT	p.F391F	FAM160B1_ENST00000369250.3_Silent_p.F391F	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	391										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						AAAGATTTTTCATTGGTGTTA	0.338000													51	213					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82836319	82836319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82836319C>T	ENST00000265077.3	+	8	8062	c.7497C>T	c.(7495-7497)tcC>tcT	p.S2499S	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.S1512S|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2499	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACAAAAGCTCCCCTGATCCAA	0.463000													12	76					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42113243	42113243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42113243C>T	ENST00000457542.2	+	23	2981	c.2695C>T	c.(2695-2697)Ctt>Ttt	p.L899F	MAPKBP1_ENST00000514566.1_Missense_Mutation_p.L899F|MAPKBP1_ENST00000260357.7_Missense_Mutation_p.L738F|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.L782F|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.L905F	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	905										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GCAGGAGGCCCTTGAGACTTC	0.612000													15	72					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71423699	71423699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71423699C>T	ENST00000302628.4	+	11	824	c.747C>T	c.(745-747)tcC>tcT	p.S249S	CALB2_ENST00000349553.5_3'UTR	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	249	EF-hand 6.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				GCGTCATGTCCTTGGCAGAGG	0.562000													39	201					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424692	125424692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125424692G>A	ENST00000373686.1	+	1	848	c.848G>A	c.(847-849)gGa>gAa	p.G283E				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G283A(1)		breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TCAGCTGCTGGAAAGCGTAAA	0.428000													77	160					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22624383	22624383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:22624383G>A	ENST00000333957.4	-	20	2563	c.2308C>T	c.(2308-2310)Ctt>Ttt	p.L770F	C2CD5_ENST00000536386.1_Missense_Mutation_p.L772F|C2CD5_ENST00000446597.1_Missense_Mutation_p.L770F|C2CD5_ENST00000545552.1_Missense_Mutation_p.L783F|C2CD5_ENST00000396028.2_Missense_Mutation_p.L761F|C2CD5_ENST00000544930.1_Missense_Mutation_p.L585F|C2CD5_ENST00000542676.1_Missense_Mutation_p.L770F	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		ACATGGCAAAGGCAGCAGGGG	0.284000													38	69					0	0	1	0	0
ATG4A	115201	broad.mit.edu	37	X	107393513	107393513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107393513C>T	ENST00000372232.3	+	10	1105	c.946C>T	c.(946-948)Cct>Tct	p.P316S	ATG4A_ENST00000345734.3_Missense_Mutation_p.P254S|COL4A6_ENST00000418180.1_Intron|ATG4A_ENST00000489247.1_3'UTR|ATG4A_ENST00000372254.3_Missense_Mutation_p.P292S|ATG4A_ENST00000545696.1_Missense_Mutation_p.P177S	NM_052936.3	NP_443168.2	Q8WYN0	ATG4A_HUMAN	autophagy related 4A, cysteine peptidase	316					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						AAACCTGGATCCTTCAGTTGC	0.488000													22	104					0	0	1	0	0
CARF	79800	broad.mit.edu	37	2	203834641	203834641	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:203834641G>A	ENST00000320443.8	+	10	1996		c.e10-1		CARF_ENST00000414439.1_Splice_Site|WDR12_ENST00000477723.1_Intron|CARF_ENST00000456821.2_Splice_Site|CARF_ENST00000402905.2_Splice_Site|CARF_ENST00000428585.1_Splice_Site|CARF_ENST00000545253.1_Splice_Site|CARF_ENST00000545262.1_Splice_Site|CARF_ENST00000438828.2_Splice_Site					calcium responsive transcription factor																		CTTGTATAAAGGATTTACATT	0.294000													13	40					0	0	1	0	0
KDM5D	8284	broad.mit.edu	37	Y	21878326	21878326	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:21878326G>C	ENST00000541639.1	-	16	2250	c.1963C>G	c.(1963-1965)Cgc>Ggc	p.R655G	KDM5D_ENST00000382806.2_Missense_Mutation_p.R567G|KDM5D_ENST00000317961.4_Missense_Mutation_p.R624G	NM_001146705.1	NP_001140177.1	Q9BY66	KDM5D_HUMAN	lysine (K)-specific demethylase 5D	624					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(1)|large_intestine(9)|lung(6)|skin(1)	17					Vitamin C(DB00126)	CGGAGCCGGCGGTAGTGTTCA	0.527000													25	14					0	0	1	0	0
MPP4	58538	broad.mit.edu	37	2	202549867	202549867	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202549867C>T	ENST00000409474.3	-	7	701	c.492_splice	c.e7-1	p.G165_splice	MPP4_ENST00000428900.2_Splice_Site_p.G165_splice|MPP4_ENST00000409143.1_Splice_Site_p.G138_splice|MPP4_ENST00000396886.3_Splice_Site_p.G121_splice|MPP4_ENST00000447335.2_Splice_Site_p.G165_splice|MPP4_ENST00000315506.7_Splice_Site_p.G165_splice|MPP4_ENST00000359962.5_Splice_Site_p.G165_splice	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	165	PDZ.					cytoplasm	protein binding			kidney(1)|lung(11)	12						GATGGTGGCTCCCTGAAGAGA	0.542000													3	16					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051521	17051521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:17051521C>T	ENST00000418129.2	+	2	770	c.305C>T	c.(304-306)tCa>tTa	p.S102L	PLCL2_ENST00000396755.2_Missense_Mutation_p.S102L|PLCL2_ENST00000460467.1_3'UTR|PLCL2_ENST00000432376.1_Missense_Mutation_p.S102L	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	228					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						AATTATGAGTCACTGGATTTG	0.403000													58	147					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4879714	4879714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:4879714G>A	ENST00000298375.7	+	5	594	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K	AKR1E2_ENST00000525281.1_3'UTR|AKR1E2_ENST00000532248.1_Missense_Mutation_p.E175K|AKR1E2_ENST00000334019.4_Missense_Mutation_p.E175K|AKR1E2_ENST00000345253.5_Intron	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	175						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						CTTCAACCATGAACAGCTTGA	0.507000													19	46					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94586593	94586593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94586593G>A	ENST00000370225.3	-	1	95	c.9C>T	c.(7-9)ttC>ttT	p.F3F	ABCA4_ENST00000535735.1_Silent_p.F3F	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	3					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTGTCTCACGAAGCCCATGC	0.507000													37	71					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56031306	56031306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56031306C>T	ENST00000309675.2	+	1	663	c.631C>T	c.(631-633)Ccc>Tcc	p.P211S		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						CATTATGATCCCCTTCTCTCT	0.557000													38	106					0	0	1	0	0
CREB3L2	64764	broad.mit.edu	37	7	137570244	137570244	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:137570244G>A	ENST00000330387.6	-	9	1399	c.1048C>T	c.(1048-1050)Ctc>Ttc	p.L350F	CREB3L2_ENST00000456390.1_Missense_Mutation_p.L350F	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	350	Leucine-zipper.				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						TGCTGAAGGAGAGTCCTGCCA	0.532000			T	FUS	fibromyxoid sarcoma								25	63					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124252337	124252337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124252337C>T	ENST00000375013.2	-	1	921	c.903G>A	c.(901-903)agG>agA	p.R301R		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TCAGAGCTTTCCTCAGTGCAA	0.348000													32	85					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238436	104238436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104238436G>A	ENST00000374851.1	-	4	2086	c.939C>T	c.(937-939)ttC>ttT	p.F313F	RP11-490D19.6_ENST00000431507.1_RNA|TMEM246_ENST00000374847.1_Silent_p.F313F|RP11-490D19.6_ENST00000450109.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374848.3_Silent_p.F313F			Q9BRR3	CI125_HUMAN	transmembrane protein 246	313						integral to membrane											GCAGTTCCAGGAAATAGTGCC	0.607000													48	78					0	0	1	0	0
TELO2	9894	broad.mit.edu	37	16	1556972	1556972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1556972C>T	ENST00000262319.6	+	18	2425	c.2146C>T	c.(2146-2148)Ctc>Ttc	p.L716F		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	716						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				GACCTTCGACCTCTTGGGAGA	0.657000													4	26					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740201	37740201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37740201C>T	ENST00000539465.1	+	15	2269	c.1676C>T	c.(1675-1677)cCt>cTt	p.P559L	FRMPD1_ENST00000377765.3_Missense_Mutation_p.P559L|FRMPD1_ENST00000541302.1_Missense_Mutation_p.P428L|FRMPD1_ENST00000536622.1_Missense_Mutation_p.P381L|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	559						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GAGGAGCAGCCTCCTGGGAAC	0.632000													13	61					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44432665	44432665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44432665C>T	ENST00000372343.3	+	18	3249	c.2587C>T	c.(2587-2589)Cgt>Tgt	p.R863C	IPO13_ENST00000372339.3_Missense_Mutation_p.R81C	NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	863					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GGAAGACGGTCGTATGCTGCT	0.612000													24	59					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24242028	24242028	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24242028G>A	ENST00000256412.4	+	1	231	c.11G>A	c.(10-12)gGg>gAg	p.G4E	RP11-624C23.1_ENST00000523700.1_RNA|ADAMDEC1_ENST00000522298.1_5'UTR|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000538205.1_5'UTR	NM_014479.3	NP_055294.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	4					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		ATGCTGCGTGGGATCTCCCAG	0.468000													12	18					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542276	55542276	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55542276A>G	ENST00000220676.1	+	4	5982	c.5834A>G	c.(5833-5835)aAt>aGt	p.N1945S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1945					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GATATTGAAAATTTCTTGGGT	0.353000													23	93					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57335973	57335973	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57335973G>A	ENST00000326441.9	-	4	414	c.51C>T	c.(49-51)gcC>gcT	p.A17A	PEG3_ENST00000594706.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Intron|PEG3_ENST00000593695.1_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Silent_p.A17A	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	17					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACAGATTTGGGGCCCAGGACT	0.453000													32	73					0	0	1	0	0
PPA2	27068	broad.mit.edu	37	4	106317465	106317465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:106317465G>A	ENST00000341695.5	-	9	840	c.810C>T	c.(808-810)tcC>tcT	p.S270S	PPA2_ENST00000380004.2_Silent_p.S252S|PPA2_ENST00000354147.3_Silent_p.S104S|PPA2_ENST00000357415.4_Silent_p.S285S|PPA2_ENST00000348706.5_Silent_p.S241S|PPA2_ENST00000432483.2_Silent_p.S168S	NM_176869.2	NP_789845.1	Q9H2U2	IPYR2_HUMAN	pyrophosphatase (inorganic) 2	270					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	11		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)		ATTGATGAGTGGATTTAATAA	0.294000													41	112					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108010940	108010940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108010940C>T	ENST00000280758.5	+	8	2604	c.2076C>T	c.(2074-2076)ctC>ctT	p.L692L	BTBD11_ENST00000420571.2_Silent_p.L692L|RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000490090.2_Silent_p.L692L|BTBD11_ENST00000357167.4_Silent_p.L229L	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	692						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AAACACCCCTCCAGCTGGCAG	0.587000													17	106					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921487	24921487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24921487G>A	ENST00000329468.2	+	1	947	c.473G>A	c.(472-474)aGa>aAa	p.R158K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GAAGGGCCCAGAAGAGTGAAG	0.617000													12	37					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	71535177	71535177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71535177C>T	ENST00000355327.3	+	5	788	c.654C>T	c.(652-654)gtC>gtT	p.V218V	THSD4_ENST00000261862.6_Silent_p.V218V			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	218	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CCCACCAGGTCCCCCAACATG	0.602000													34	85					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228155603	228155603	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228155603G>A	ENST00000396578.3	+	37	3372		c.e37+1		AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)						activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGGACCAACGGTATATAGGCC	0.478000													5	21					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41008721	41008721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41008721G>A	ENST00000399564.4	-	33	4045	c.3595C>T	c.(3595-3597)Cca>Tca	p.P1199S	MROH2B_ENST00000506092.2_Missense_Mutation_p.P754S	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B									p.P1199S(1)									CAGGGGTCTGGGATCTGCTGC	0.567000													26	47					0	0	1	0	0
SLC25A32	81034	broad.mit.edu	37	8	104412716	104412716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:104412716G>A	ENST00000297578.4	-	7	1037	c.871C>T	c.(871-873)Cca>Tca	p.P291S	SLC25A32_ENST00000543107.1_Missense_Mutation_p.P159S	NM_030780.3	NP_110407.2	Q9H2D1	MFTC_HUMAN	solute carrier family 25 (mitochondrial folate carrier), member 32	291					folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	9			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	CAGCAGGCTGGAGTCACTCTA	0.368000													13	140					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	169985283	169985283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169985283G>A	ENST00000263816.3	-	79	14143	c.13858C>T	c.(13858-13860)Cct>Tct	p.P4620S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4620					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGCTTAGCAGGGAGCGAAGGT	0.453000													46	129					0	0	1	0	0
GPM6A	2823	broad.mit.edu	37	4	176556167	176556167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:176556167C>T	ENST00000280187.7	-	8	771	c.726G>A	c.(724-726)gtG>gtA	p.V242V	GPM6A_ENST00000506219.1_5'UTR|GPM6A_ENST00000506894.1_Silent_p.V231V|GPM6A_ENST00000515090.1_Silent_p.V235V|GPM6A_ENST00000393658.2_Silent_p.V242V	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	242			V -> L (in dbSNP:rs1049820).			cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		AGGCGTCTTTCACATAGGCCC	0.433000													16	43					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42344708	42344708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42344708G>A	ENST00000217026.4	+	14	2211	c.2084G>A	c.(2083-2085)cGg>cAg	p.R695Q	MYBL2_ENST00000396863.4_Missense_Mutation_p.R671Q	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	695						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CACACATCTCGGACCCTCATC	0.607000													54	210					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12225853	12225853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12225853C>T	ENST00000256194.4	+	4	609	c.321C>T	c.(319-321)taC>taT	p.Y107Y	MICAL2_ENST00000527195.1_3'UTR|MICAL2_ENST00000379612.3_Silent_p.Y107Y|MICAL2_ENST00000342902.5_Silent_p.Y107Y|MICAL2_ENST00000527546.1_Silent_p.Y107Y|MICAL2_ENST00000537344.1_Silent_p.Y107Y	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	107						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		AACTTGCCTACCTGGGAGCCA	0.567000													10	56					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624347	123624347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123624347C>T	ENST00000327930.2	-	1	906	c.880G>A	c.(880-882)Gag>Aag	p.E294K		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CCCTTCACCTCCTTGTTTCTA	0.403000													57	142					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74013916	74013916	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74013916C>T	ENST00000301607.3	-	14	1867	c.1614G>A	c.(1612-1614)ctG>ctA	p.L538L	EVPL_ENST00000586740.1_Silent_p.L560L	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	538	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CTATCTGTCCCAGGTCTCCAT	0.672000													21	53					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111866190	111866190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111866190G>A	ENST00000440460.2	+	17	1885	c.1588G>A	c.(1588-1590)Gat>Aat	p.D530N	DIXDC1_ENST00000389821.4_3'UTR|DIXDC1_ENST00000315253.5_Missense_Mutation_p.D319N	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	531					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		CAGTGGCCACGATCCTCAGCA	0.542000													28	66					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89068470	89068470	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:89068470T>G	ENST00000286614.6	-	8	1540	c.1259A>C	c.(1258-1260)cAa>cCa	p.Q420P		NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	420	Hemopexin-like 2.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GTAACCAGGTTGAAGAGTTGT	0.363000													33	67					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169127034	169127034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169127034G>A	ENST00000256935.8	+	13	1229	c.1149G>A	c.(1147-1149)atG>atA	p.M383I		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	383					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGTGACCATGAAGATGCTGG	0.582000													46	177					0	0	1	0	0
TMPRSS12	283471	broad.mit.edu	37	12	51237684	51237684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51237684G>A	ENST00000551456.1	+	2	292	c.247G>A	c.(247-249)Gaa>Aaa	p.E83K	TMPRSS12_ENST00000398458.3_Missense_Mutation_p.E83K			Q86WS5	TMPSC_HUMAN	transmembrane (C-terminal) protease, serine 12	83	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	18						AGGGGGCACCGAAGCACAAGC	0.473000													6	6					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6243300	6243300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6243300G>A	ENST00000400104.3	-	7	653	c.453C>T	c.(451-453)atC>atT	p.I151I	L3MBTL4_ENST00000400105.2_Silent_p.I151I|L3MBTL4_ENST00000284898.6_Silent_p.I151I|L3MBTL4_ENST00000317931.7_Silent_p.I151I			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	151					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TACCCTTAGGGATGTGCAGTT	0.368000													26	88					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18896805	18896805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18896805C>T	ENST00000542601.2	-	12	1749	c.1360G>A	c.(1360-1362)Gtg>Atg	p.V454M	COMP_ENST00000425807.1_Missense_Mutation_p.V434M|COMP_ENST00000222271.2_Missense_Mutation_p.V487M			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	487					anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						GGGTTAGGCACCAGGCGGCAG	0.716000													6	27					0	0	1	0	0
IGHV4-59	28392	broad.mit.edu	37	14	107083658	107083658	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107083658G>A	ENST00000455737.1	-	0	67																											GCTGCCACCAGGAGAAGGAAG	0.507000													18	71					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52902752	52902752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52902752G>A	ENST00000356971.3	-	4	630	c.141C>T	c.(139-141)aaC>aaT	p.N47N	ICK_ENST00000350082.5_Silent_p.N47N	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	47	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					CCTCCCGAAGGTTCATGCATT	0.299000													22	47					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102494353	102494353	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102494353C>T	ENST00000360184.4	+	48	9507	c.9343C>T	c.(9343-9345)Ctg>Ttg	p.L3115L		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3115	AAA 4 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TAAGATGGATCTGGAGAAGCC	0.478000													15	234					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833794	61833794	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61833794G>A	ENST00000280772.1	-	37	7036	c.6845C>T	c.(6844-6846)tCc>tTc	p.S2282F	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2282					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATCCCGCCCGGACTGAAAGGC	0.493000													14	188					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23762076	23762076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:23762076C>T	ENST00000397312.2	-	2	431	c.157G>A	c.(157-159)Gag>Aag	p.E53K	ELAVL2_ENST00000544538.1_Missense_Mutation_p.E53K|ELAVL2_ENST00000380117.1_Missense_Mutation_p.E53K|ELAVL2_ENST00000380110.4_Missense_Mutation_p.E82K|ELAVL2_ENST00000223951.6_Missense_Mutation_p.E53K	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	53	RRM 1.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TTTAGTTCCTCCTGTGTCATG	0.398000													19	112					0	0	1	0	0
LGALS3BP	3959	broad.mit.edu	37	17	76967691	76967691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76967691G>A	ENST00000262776.3	-	6	2033	c.1725C>T	c.(1723-1725)ccC>ccT	p.P575P	LGALS3BP_ENST00000591778.1_3'UTR	NM_005567.3	NP_005558.1	Q08380	LG3BP_HUMAN	lectin, galactoside-binding, soluble, 3 binding protein	575					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(5)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			TCAGGTAGAAGGGGCGGATGA	0.647000											OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	34					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2025692	2025692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2025692C>T	ENST00000568546.1	+	10	1096	c.968C>T	c.(967-969)tCc>tTc	p.S323F		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	323					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						GAGGCTCGCTCCCTGCGGCTG	0.667000													11	44					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76912528	76912528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76912528G>A	ENST00000409709.3	+	36	5160	c.4888G>A	c.(4888-4890)Gga>Aga	p.G1630R	MYO7A_ENST00000409619.2_Missense_Mutation_p.G1581R|MYO7A_ENST00000458637.2_Missense_Mutation_p.G1592R	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1630	SH3.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CTTTGCCAAGGGAGACCTCAT	0.597000													15	29					0	0	1	0	0
ERP27	121506	broad.mit.edu	37	12	15090925	15090925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15090925G>A	ENST00000266397.2	-	2	729	c.156C>T	c.(154-156)ttC>ttT	p.F52F		NM_152321.2	NP_689534.1	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27	52	Thioredoxin.		F -> L (in dbSNP:rs35030722).			endoplasmic reticulum lumen				breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(3)|prostate(2)|skin(1)	19						TGGCAGCAATGAATTCCATGG	0.522000													12	154					0	0	1	0	0
PTBP2	58155	broad.mit.edu	37	1	97236339	97236339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:97236339C>T	ENST00000236228.6	+	5	446	c.364C>T	c.(364-366)Cgt>Tgt	p.R122C	PTBP2_ENST00000541987.1_Missense_Mutation_p.R91C|PTBP2_ENST00000370198.1_Missense_Mutation_p.R122C|PTBP2_ENST00000482253.1_3'UTR|PTBP2_ENST00000426398.2_Missense_Mutation_p.R122C|PTBP2_ENST00000394184.3_Missense_Mutation_p.R133C|PTBP2_ENST00000370197.1_Missense_Mutation_p.R122C	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	122	RRM 1.						nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		ACCTCATCTTCGTAACCAACC	0.338000													20	115					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2818707	2818707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2818707C>T	ENST00000520002.1	-	63	10216	c.9661G>A	c.(9661-9663)Ggt>Agt	p.G3221S	CSMD1_ENST00000542608.1_Missense_Mutation_p.G3043S|CSMD1_ENST00000400186.3_Missense_Mutation_p.G3044S|CSMD1_ENST00000602557.1_Missense_Mutation_p.G3221S|CSMD1_ENST00000537824.1_Missense_Mutation_p.G3220S|CSMD1_ENST00000602723.1_Missense_Mutation_p.G3044S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3221	Sushi 27.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTGGCGTACCAGGGTCTGGG	0.353000													8	28					0	0	1	0	0
USO1	8615	broad.mit.edu	37	4	76650013	76650013	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76650013C>A	ENST00000538159.1	+	1	10	c.10C>A	c.(10-12)Ctc>Atc	p.L4I	USO1_ENST00000514213.2_Missense_Mutation_p.L4I			O60763	USO1_HUMAN	USO1 vesicle transport factor	4	Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GATGAATTTCCTCCGCGGGGT	0.642000													6	41					0.00307968	0.003082	1	1	0
TRAV13-1	28671	broad.mit.edu	37	14	22337337	22337337	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22337337C>T	ENST00000390436.2	+	0	151																											ATCAAGTGTACTTATTCAGAC	0.438000													53	103					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573509	140573509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140573509G>A	ENST00000239446.4	+	1	1568	c.1384G>A	c.(1384-1386)Gag>Aag	p.E462K		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		462	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGTCCGCGAGAACAACAG	0.627000													65	185					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584053	179584053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179584053C>T	ENST00000589042.1	-	83	24288	c.24064G>A	c.(24064-24066)Gga>Aga	p.G8022R	TTN_ENST00000342992.6_Missense_Mutation_p.G6778R|TTN_ENST00000591111.1_Missense_Mutation_p.G7705R|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7705	Ig-like 62.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCATTTCCATCCTGAAAC	0.512000													61	123					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90435980	90435980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90435980G>A	ENST00000394375.3	+	10	1046	c.933G>A	c.(931-933)ggG>ggA	p.G311G	LIPF_ENST00000238983.4_Silent_p.G301G|LIPF_ENST00000355843.2_Silent_p.G268G|LIPF_ENST00000496797.1_3'UTR	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	301					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		TTAAGTCTGGGAAATTCCAAG	0.308000													12	51					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135203728	135203728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135203728G>A	ENST00000372169.2	-	10	3439	c.3257C>T	c.(3256-3258)tCa>tTa	p.S1086L	SETX_ENST00000393220.1_Missense_Mutation_p.S1086L|SETX_ENST00000224140.5_Missense_Mutation_p.S1086L			Q7Z333	SETX_HUMAN	senataxin	1086					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CACTTCAGATGAACTTTCAAA	0.348000													14	103					0	0	1	0	0
CRTAM	56253	broad.mit.edu	37	11	122738187	122738187	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:122738187C>T	ENST00000227348.4	+	8	935	c.888C>T	c.(886-888)ttC>ttT	p.F296F	CRTAM_ENST00000533709.1_Silent_p.F97F	NM_019604.2	NP_062550.2	O95727	CRTAM_HUMAN	cytotoxic and regulatory T cell molecule	296					cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TGGTGTCCTTCCTCATTTTCA	0.438000													12	43					0	0	1	0	0
OR5B2	390190	broad.mit.edu	37	11	58190468	58190468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58190468G>A	ENST00000302581.2	-	1	318	c.267C>T	c.(265-267)gtC>gtT	p.V89V		NM_001005566.2	NP_001005566.1	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B, member 2	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGTAGGAGATGACCTTGTCTC	0.488000													45	122					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109696929	109696929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:109696929C>T	ENST00000465301.2	+	3	3330	c.3084C>T	c.(3082-3084)tcC>tcT	p.S1028S	RGAG1_ENST00000540313.1_Silent_p.S1028S	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1028										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						GAGCAAGGTCCACATCATTTA	0.498000													61	47					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731956	140731956	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140731956G>T	ENST00000523390.1	+	1	2129	c.2129G>T	c.(2128-2130)cGc>cTc	p.R710L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGCCCTGCGCCTGCGACGT	0.612000													38	185					2.35968e-33	2.37621e-33	1	1	0
GRIA1	2890	broad.mit.edu	37	5	153026600	153026600	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153026600G>A	ENST00000285900.5	+	3	676	c.333G>A	c.(331-333)ccG>ccA	p.P111P	GRIA1_ENST00000518142.1_Intron|GRIA1_ENST00000518862.1_3'UTR|GRIA1_ENST00000518783.1_Silent_p.P121P|GRIA1_ENST00000521843.2_Silent_p.P42P|GRIA1_ENST00000448073.4_Silent_p.P121P|GRIA1_ENST00000340592.5_Silent_p.P111P	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	111					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCATTACGCCGAGCTTTCCCG	0.493000													47	116					0	0	1	0	0
NCAPH2	29781	broad.mit.edu	37	22	50956060	50956060	+	Silent	SNP	C	C	T	rs150150677		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50956060C>T	ENST00000395701.3	+	4	415	c.321C>T	c.(319-321)agC>agT	p.S107S	NCAPH2_ENST00000420993.2_Silent_p.S107S|NCAPH2_ENST00000299821.11_Silent_p.S107S|NCAPH2_ENST00000395698.3_Silent_p.S107S			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	107					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		GGGTTGCCAGCTCCGGGGTCC	0.652000													26	74					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60370618	60370618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60370618C>T	ENST00000371204.3	-	7	1159	c.1116G>A	c.(1114-1116)atG>atA	p.M372I	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	372					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					TGATGTTGCCCATTCTCTGCA	0.557000													34	85					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160459991	160459991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160459991G>A	ENST00000368059.3	-	5	862	c.793C>T	c.(793-795)Ccc>Tcc	p.P265S	SLAMF6_ENST00000368055.1_Missense_Mutation_p.P154S|SLAMF6_ENST00000368057.3_Missense_Mutation_p.P265S	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	265						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TGCTCACCGGGGCCCTGTGTT	0.478000													35	120					0	0	1	0	0
HEXA	3073	broad.mit.edu	37	15	72640430	72640430	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72640430G>A	ENST00000268097.5	-	9	1535	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F	RP11-106M3.3_ENST00000570175.1_RNA|HEXA_ENST00000567159.1_Silent_p.F344F|RP11-106M3.2_ENST00000379915.4_RNA|HEXA_ENST00000457859.2_Silent_p.F152F|HEXA_ENST00000566304.1_Silent_p.F355F|HEXA_ENST00000429918.2_Silent_p.F171F	NM_000520.4	NP_000511.2	P06865	HEXA_HUMAN	hexosaminidase A (alpha polypeptide)	344					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(3)|kidney(3)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	24						AGTCCTCACCGAAGCCTTTCT	0.517000													21	82					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67629324	67629324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:67629324G>A	ENST00000335894.4	+	5	465	c.399G>A	c.(397-399)tcG>tcA	p.S133S	IQCH_ENST00000358767.3_5'UTR|IQCH_ENST00000546225.1_5'UTR	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	133										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		TAAAGGTTTCGAAGTTAATCA	0.343000													45	74					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150817106	150817106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150817106G>A	ENST00000370357.4	+	9	894	c.649G>A	c.(649-651)Gga>Aga	p.G217R		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	217						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTCAAAGAGGACACACTAG	0.408000													92	57					0	0	1	0	0
STAT6	6778	broad.mit.edu	37	12	57496103	57496103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57496103G>A	ENST00000300134.3	-	13	1807	c.1482C>T	c.(1480-1482)caC>caT	p.H494H	STAT6_ENST00000556155.1_Silent_p.H494H|STAT6_ENST00000538913.2_Silent_p.H384H|STAT6_ENST00000537215.2_Silent_p.H384H|STAT6_ENST00000543873.2_Silent_p.H494H|STAT6_ENST00000454075.3_Silent_p.H494H	NM_001178078.1|NM_003153.4	NP_001171549.1|NP_003144.3	P42226	STAT6_HUMAN	signal transducer and activator of transcription 6, interleukin-4 induced	494					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	28						ACACAGAACGGTGCTGGAAGG	0.597000													54	126					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18865911	18865911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18865911C>T	ENST00000447925.2	-	6	842	c.573G>A	c.(571-573)gtG>gtA	p.V191V	PLCZ1_ENST00000538330.1_5'UTR|PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000435379.1_Intron|PLCZ1_ENST00000541695.1_Silent_p.V56V|PLCZ1_ENST00000266505.7_Silent_p.V193V	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	193	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					GGCATCCTTTCACAAGGGCAC	0.348000													22	55					0	0	1	0	0
OR2B3	442184	broad.mit.edu	37	6	29054214	29054214	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29054214C>T	ENST00000377173.2	-	1	876	c.812G>A	c.(811-813)gGa>gAa	p.G271E		NM_001005226.2	NP_001005226.1			olfactory receptor, family 2, subfamily B, member 3											breast(1)|endometrium(1)|kidney(2)|lung(17)|prostate(1)|skin(2)	24						AACCATCTTTCCCCAGTCCTT	0.443000													9	63					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118293378	118293378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:118293378G>A	ENST00000425217.1	-	3	294	c.240C>T	c.(238-240)atC>atT	p.I80I	KSR2_ENST00000339824.5_Silent_p.I109I	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	109					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCCGGGGGAGATTTCCTAGA	0.602000													9	30					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3334455	3334455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3334455G>A	ENST00000378398.3	+	12	2837	c.2755G>A	c.(2755-2757)Ggc>Agc	p.G919S	PRDM16_ENST00000378391.2_Missense_Mutation_p.G919S|PRDM16_ENST00000442529.2_Missense_Mutation_p.G918S|PRDM16_ENST00000441472.2_Missense_Mutation_p.G918S|PRDM16_ENST00000514189.1_Missense_Mutation_p.G919S|PRDM16_ENST00000511072.1_Missense_Mutation_p.G920S|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Missense_Mutation_p.G919S			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	919	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GGCGGACTCGGGCAGCTCCCT	0.602000			T	EVI1	"""MDS, AML"""								38	112					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74978059	74978059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74978059C>T	ENST00000261978.4	-	19	3303	c.2917G>A	c.(2917-2919)Gaa>Aaa	p.E973K	LTBP2_ENST00000556690.1_Missense_Mutation_p.E973K	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	973	Cys-rich.|EGF-like 7; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TGACGGCATTCGTTGATATCT	0.572000													33	89					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660591	77660591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77660591C>T	ENST00000296043.6	+	5	2218	c.1265C>T	c.(1264-1266)tCc>tTc	p.S422F		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	422					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TCTTTAGGCTCCCTGAAGTCT	0.552000													25	56					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36897082	36897082	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36897082C>T	ENST00000301807.6	-	12	4246	c.2349G>A	c.(2347-2349)ggG>ggA	p.G783G	TRANK1_ENST00000429976.2_Silent_p.G1333G|TRANK1_ENST00000428977.2_Silent_p.G783G	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1333					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ACCGTTTCCTCCCTAATTTCT	0.428000													43	110					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99655719	99655719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:99655719C>T	ENST00000370597.3	-	10	1595	c.1240G>A	c.(1240-1242)Gga>Aga	p.G414R	CRTAC1_ENST00000298819.4_Missense_Mutation_p.G414R|CRTAC1_ENST00000370591.2_Missense_Mutation_p.G414R	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	414						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		ATCCCGTCTCCGTCGAAGTCG	0.582000													6	68					0	0	1	0	0
GSR	2936	broad.mit.edu	37	8	30560722	30560722	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30560722G>A	ENST00000221130.5	-	5	618	c.528C>T	c.(526-528)ttC>ttT	p.F176F	GSR_ENST00000414019.1_Silent_p.F133F|GSR_ENST00000541648.1_Silent_p.F176F|GSR_ENST00000546342.1_Silent_p.F176F|GSR_ENST00000537535.1_Silent_p.F176F	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	176					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	GATCACTCGTGAAGGCTGCAT	0.483000													38	88					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24392293	24392293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24392293C>T	ENST00000329601.7	-	30	3790	c.3628G>A	c.(3628-3630)Ggg>Agg	p.G1210R	MYOM3_ENST00000338909.5_Intron|MYOM3_ENST00000374434.3_Intron|RP11-293P20.2_ENST00000439239.2_RNA|MYOM3_ENST00000330966.7_Intron			Q5VTT5	MYOM3_HUMAN	myomesin 3	0										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		agcctcggccctgCCCTGACT	0.498000													4	30					0	0	1	0	0
OVCH2	341277	broad.mit.edu	37	11	7723765	7723765	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7723765G>A	ENST00000454689.1	-	0	401				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GTTTCTTGGTGGAGAAATGTG	0.418000													16	19					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28537605	28537605	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:28537605G>A	ENST00000401766.2	-	10	1889	c.1377C>T	c.(1375-1377)gcC>gcT	p.A459A	SLC6A4_ENST00000261707.3_Silent_p.A459A			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	459					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CCCGGCGCTTGGCCCAGACGT	0.587000													8	73					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870386	51870386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51870386C>T	ENST00000371497.5	+	2	1276	c.389C>T	c.(388-390)gCc>gTc	p.A130V	TSHZ2_ENST00000603338.2_Missense_Mutation_p.A127V|TSHZ2_ENST00000329613.6_Missense_Mutation_p.A127V	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	130					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			GCTGTCTACGCCAACATCCTG	0.527000													19	50					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228137704	228137704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228137704G>A	ENST00000396578.3	+	26	1960	c.1798G>A	c.(1798-1800)Gat>Aat	p.D600N	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	600	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TCCTCCAGGGGATCCTGGCTC	0.567000													22	58					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306918	54306918	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54306918G>A	ENST00000545554.1	+	1	1818	c.1818G>A	c.(1816-1818)ttG>ttA	p.L606L	UNC13C_ENST00000537900.1_Silent_p.L606L|UNC13C_ENST00000260323.11_Silent_p.L606L			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	606					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ACCAGCATTTGAATGGAGGTG	0.502000													16	99					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125175031	125175031	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125175031A>G	ENST00000431078.1	+	4	757	c.393A>G	c.(391-393)ggA>ggG	p.G131G		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	131	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCTTTGCAGGAAACATGAATG	0.488000													8	26					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175576	143175576	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143175576T>A	ENST00000408916.1	+	1	611	c.611T>A	c.(610-612)aTt>aAt	p.I204N	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	204					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					ATGCTGTTAATTAATTCTCTG	0.463000													24	51					0	0	1	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242741358	242741358	+	Silent	SNP	C	C	T	rs140456342		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242741358C>T	ENST00000192314.6	+	3	413	c.282C>T	c.(280-282)taC>taT	p.Y94Y		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	94					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		ACCTGGGCTACCCCTGGCTCT	0.657000													23	49					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333557	70333557	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70333557C>T	ENST00000338508.4	-	32	2843	c.2844G>A	c.(2842-2844)gaG>gaA	p.E948E	SHANK2_ENST00000423696.2_Silent_p.E568E|SHANK2_ENST00000409161.1_Silent_p.E351E|SHANK2_ENST00000449833.2_Silent_p.E352E			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	568					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACATCCCCTTCTCCCTCATCA	0.577000													21	39					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57078909	57078909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57078909G>A	ENST00000316981.3	-	5	1875	c.1396C>T	c.(1396-1398)Cct>Tct	p.P466S	PLAG1_ENST00000429357.2_Missense_Mutation_p.P466S|PLAG1_ENST00000423799.2_Missense_Mutation_p.P384S	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	466	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Massively activates transcription.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GTGTTTGCAGGATCCTGAAGA	0.498000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								25	165					0	0	1	0	0
NARS2	79731	broad.mit.edu	37	11	78147847	78147847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78147847G>A	ENST00000281038.5	-	14	1678	c.1303C>T	c.(1303-1305)Cgt>Tgt	p.R435C	RP11-452H21.1_ENST00000534168.1_RNA|NARS2_ENST00000528850.1_Missense_Mutation_p.R208C	NM_001243251.1|NM_024678.5	NP_001230180.1|NP_078954.4	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial (putative)	435					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding	p.R435C(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)	27	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CCAAATCGACGAAGGTCCAGA	0.358000													68	171					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51562352	51562352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:51562352G>A	ENST00000298239.6	+	3	223	c.191G>A	c.(190-192)aGa>aAa	p.R64K	MSMB_ENST00000358559.2_Silent_p.E99E	NM_138634.2	NP_619540.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	0						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						TCGTGGTGGAGAAGAAGGACC	0.463000													59	130					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254947	51254947	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:51254947G>A	ENST00000404971.1	-	2	1804	c.465C>T	c.(463-465)gtC>gtT	p.V155V	NRXN1_ENST00000405581.1_Silent_p.V155V|NRXN1_ENST00000402717.3_Silent_p.V155V|NRXN1_ENST00000401669.2_Silent_p.V155V|NRXN1_ENST00000406316.2_Silent_p.V155V|NRXN1_ENST00000405472.3_Silent_p.V155V|NRXN1_ENST00000406859.3_Silent_p.V155V	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	155	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCAGCCCCCCGACGAAAAGGC	0.662000													10	24					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443930	5443930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5443930G>A	ENST00000300778.4	+	1	590	c.500G>A	c.(499-501)cGa>cAa	p.R167Q	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTACTCAAGCGACTGCCTTTC	0.517000													106	226					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49918253	49918253	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49918253G>A	ENST00000447857.3	+	17	1579	c.1374_splice	c.e17+1	p.T458_splice		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	458						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						GCCAGGTCACGGTAGGCAGTC	0.592000													11	17					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126132960	126132960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126132960C>T	ENST00000393425.1	+	4	262	c.163C>T	c.(163-165)Cac>Tac	p.H55Y	CCDC37_ENST00000510833.1_Missense_Mutation_p.H55Y|CCDC37_ENST00000352312.1_Missense_Mutation_p.H55Y|CCDC37_ENST00000505024.1_Missense_Mutation_p.H55Y			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	55										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		GAACCCTTTCCACTTATCTGG	0.567000													90	300					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432511	140432511	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140432511C>T	ENST00000306549.3	+	1	1533	c.1456C>T	c.(1456-1458)Caa>Taa	p.Q486*		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		486	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAGAATGCCCAAATAACATA	0.423000													13	55					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075418	76075418	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:76075418G>A	ENST00000395215.3	+	0	1058																											GAGGCTTCGGGAGCAGCAGAA	0.607000													146	174					0	0	1	0	0
RRP9	9136	broad.mit.edu	37	3	51969369	51969369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51969369G>A	ENST00000232888.6	-	10	1033	c.960C>T	c.(958-960)ttC>ttT	p.F320F		NM_004704.3	NP_004695.1	O43818	U3IP2_HUMAN	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	320					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|skin(1)	21				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		GGTGGCCATAGAAGACAAGCT	0.652000													15	26					0	0	1	0	0
BARX2	8538	broad.mit.edu	37	11	129321287	129321287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:129321287C>T	ENST00000281437.4	+	4	926	c.830C>T	c.(829-831)cCa>cTa	p.P277L	BARX2_ENST00000526127.1_Missense_Mutation_p.P132L|BARX2_ENST00000531946.1_Missense_Mutation_p.P155L	NM_003658.4	NP_003649.2	Q9UMQ3	BARX2_HUMAN	BARX homeobox 2	277										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	20	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		GAACCCCCACCATTAAGCTAA	0.542000													25	65					0	0	1	0	0
RASL12	51285	broad.mit.edu	37	15	65347440	65347440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65347440C>T	ENST00000220062.4	-	5	874	c.598G>A	c.(598-600)Gag>Aag	p.E200K	RASL12_ENST00000434605.2_Missense_Mutation_p.E189K|RASL12_ENST00000421977.3_Missense_Mutation_p.E181K	NM_016563.2	NP_057647.1	Q9NYN1	RASLC_HUMAN	RAS-like, family 12	200					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			lung(1)|ovary(1)|skin(1)|urinary_tract(1)	4						GCCCTCTCCTCGGAGATGAAG	0.662000													12	21					0	0	1	0	0
DCST2	127579	broad.mit.edu	37	1	155004051	155004051	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155004051G>A	ENST00000368424.3	-	4	796	c.739_splice	c.e4+1	p.S246_splice	DCST2_ENST00000295536.5_Splice_Site_p.S246_splice	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	246						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTTTCTCACGGCTGGCAAGTC	0.602000													26	59					0	0	1	0	0
KATNAL2	83473	broad.mit.edu	37	18	44584634	44584634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44584634C>T	ENST00000245121.5	+	4	339	c.145C>T	c.(145-147)Ccc>Tcc	p.P49S	KATNAL2_ENST00000356157.7_Missense_Mutation_p.P121S|KATNAL2_ENST00000592005.1_Intron	NM_031303.2	NP_112593.2	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	121	LisH.					cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			central_nervous_system(2)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	27						TCAAAATCTTCCCAAGATCAA	0.458000													32	71					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52591937	52591937	+	Silent	SNP	C	C	T	rs139421363		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:52591937C>T	ENST00000395961.3	-	8	1339	c.1173G>A	c.(1171-1173)gcG>gcA	p.A391A	BCAS1_ENST00000371435.2_Silent_p.A391A|BCAS1_ENST00000371440.3_Intron|BCAS1_ENST00000434986.2_Intron	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	391						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CATTCTCCTCCGCACCTGTGG	0.413000													11	32					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56549453	56549453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56549453C>T	ENST00000390649.3	+	10	2678	c.2678C>T	c.(2677-2679)tCc>tTc	p.S893F		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	893						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTTACGACCTCCCCCAGCCTG	0.552000													12	59					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75325210	75325210	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75325210T>G	ENST00000556489.2	-	2	1312	c.1313A>C	c.(1312-1314)gAg>gCg	p.E438A	PROX2_ENST00000556084.2_Intron|PROX2_ENST00000445876.1_Splice_Site_p.E438_splice	NM_001243007.1	NP_001229936.1	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	438					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GTTTAGACCCTCCTGGATTTA	0.383000													7	7					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189912956	189912956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189912956C>T	ENST00000374866.3	-	45	3454	c.3180G>A	c.(3178-3180)cgG>cgA	p.R1060R		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1060					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CAGCACCATCCCGTCCTGGGG	0.348000													22	55					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15973617	15973617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:15973617G>A	ENST00000268712.3	-	31	4632	c.4375C>T	c.(4375-4377)Ctt>Ttt	p.L1459F	NCOR1_ENST00000395851.1_Missense_Mutation_p.L1475F|NCOR1_ENST00000395857.3_Missense_Mutation_p.L43F	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1459	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTGGACCTAAGAACGGAGGGG	0.522000													46	113					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30704350	30704350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30704350C>T	ENST00000256246.2	-	1	2258	c.2184G>A	c.(2182-2184)ggG>ggA	p.G728G		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	728										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTTCCATCTCCCCGTTATCAA	0.388000													16	129					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28284008	28284008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28284008C>T	ENST00000305242.5	-	2	156	c.64G>A	c.(64-66)Gaa>Aaa	p.E22K		NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	22							binding	p.E22K(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GGGGTGATTTCGAGGATTCCA	0.453000													19	53					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110454763	110454763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110454763C>T	ENST00000506538.2	+	17	2590	c.2017C>T	c.(2017-2019)Cct>Tct	p.P673S	WDR36_ENST00000513710.2_Missense_Mutation_p.P673S	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	673					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TTCTATGTCTCCTACTGGAGA	0.373000													56	142					0	0	1	0	0
IL5RA	3568	broad.mit.edu	37	3	3118303	3118303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3118303C>T	ENST00000446632.2	-	10	1577	c.1003G>A	c.(1003-1005)Gaa>Aaa	p.E335K	IL5RA_ENST00000256452.3_Missense_Mutation_p.E335K|IL5RA_ENST00000438560.1_Missense_Mutation_p.E335K|IL5RA_ENST00000445864.2_Missense_Mutation_p.E126K|IL5RA_ENST00000418488.2_Missense_Mutation_p.E240K	NM_175726.3	NP_783853.1	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha	335					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	24				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		GGCTTGTGTTCATCATTTCCT	0.373000													8	51					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38959746	38959746	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38959746C>T	ENST00000355481.4	+	26	3653	c.3522C>T	c.(3520-3522)tcC>tcT	p.S1174S	RYR1_ENST00000359596.3_Silent_p.S1174S|RYR1_ENST00000360985.3_Silent_p.S1174S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1174	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACTCAGGCTCCGAAACAGCCT	0.562000													24	65					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15646222	15646222	+	Silent	SNP	G	G	A	rs45604340		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15646222G>A	ENST00000378076.3	-	20	2456	c.2103C>T	c.(2101-2103)atC>atT	p.I701I	ITGA8_ENST00000477064.1_5'UTR	NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	701					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	p.I701I(1)		NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TGTTGCGTTCGATTCCAACAT	0.378000													32	85					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634267	70634267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70634267C>T	ENST00000381269.2	-	2	1626	c.873G>A	c.(871-873)atG>atA	p.M291I	SLC8A3_ENST00000528359.1_Missense_Mutation_p.M291I|SLC8A3_ENST00000357887.3_Missense_Mutation_p.M291I|SLC8A3_ENST00000534137.1_Missense_Mutation_p.M291I|SLC8A3_ENST00000356921.2_Missense_Mutation_p.M291I	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	291					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GGGAATTCATCATTTTCCCAT	0.478000													28	45					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066477	73066477	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73066477G>A	ENST00000429829.1	-	0	6111					NR_001564.2																						GGTCTTATGGGGTGGGCACTT	0.468000													31	17					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872865	55872865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55872865C>T	ENST00000313503.1	+	1	347	c.347C>T	c.(346-348)tCc>tTc	p.S116F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TACCTTCTCTCCTCAATGGCC	0.463000										HNSCC(53;0.14)			103	299					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13092387	13092387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:13092387C>T	ENST00000506447.1	+	34	6195	c.6115C>T	c.(6115-6117)Ccc>Tcc	p.P2039S	CEP192_ENST00000430049.2_Missense_Mutation_p.P1564S|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000325971.8_Missense_Mutation_p.P1443S	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1634										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ATATGATCTTCCCCAACGACC	0.308000													18	49					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159660564	159660564	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159660564C>T	ENST00000297267.9	+	14	4396	c.4196C>T	c.(4195-4197)cCc>cTc	p.P1399L	FNDC1_ENST00000340366.6_Missense_Mutation_p.P1336L	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1399						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GAAGGGACCCCCGTGGTGAGT	0.483000													4	6					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89524656	89524656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89524656C>T	ENST00000370473.4	-	5	718	c.499G>A	c.(499-501)Gat>Aat	p.D167N		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	167					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCAGCTGAATCCTCAACCTCA	0.453000													40	74					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096686	167096686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167096686G>A	ENST00000361200.2	+	6	2484	c.2318G>A	c.(2317-2319)gGa>gAa	p.G773E	DUSP27_ENST00000443333.1_Missense_Mutation_p.G773E|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.G773E			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	773					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						ATGCTTAGTGGACACAGCAGC	0.577000													15	84					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104025408	104025408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104025408G>A	ENST00000388887.2	+	6	724	c.520G>A	c.(520-522)Gga>Aga	p.G174R		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	174	EGF-like 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTGCAACAGTGGACTAGATGG	0.488000													39	153					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62178649	62178649	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62178649G>A	ENST00000217188.1	-	1	208	c.168C>T	c.(166-168)ttC>ttT	p.F56F		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	56	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			AGAGCGCAAGGAAGAGCTGAG	0.701000													6	20					0	0	1	0	0
ASRGL1	80150	broad.mit.edu	37	11	62123837	62123837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62123837G>A	ENST00000415229.2	+	3	446	c.231G>A	c.(229-231)atG>atA	p.M77I	ASRGL1_ENST00000535727.1_Intron|ASRGL1_ENST00000301776.5_Missense_Mutation_p.M77I	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	77					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	AGGTTGAAATGGATGCTAGTA	0.448000													40	111					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28474625	28474625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28474625G>A	ENST00000261609.7	-	33	5209	c.5101C>T	c.(5101-5103)Cct>Tct	p.P1701S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1701					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATTCCCTCAGGAATAAGTCTT	0.383000													45	106					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38830179	38830179	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38830179C>T	ENST00000359357.3	+	42	5858	c.5604C>T	c.(5602-5604)gtC>gtT	p.V1868V	DNAH8_ENST00000441566.1_Silent_p.V1868V|DNAH8_ENST00000449981.2_Silent_p.V2085V					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AATATGTGGTCGTGTTCAATT	0.423000													43	129					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361655	107361655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107361655G>A	ENST00000374779.2	-	1	133	c.40C>T	c.(40-42)Ctg>Ttg	p.L14L		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						AGTCCCTTCAGAAAAAATTCC	0.383000													24	91					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72286851	72286851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72286851G>A	ENST00000356056.5	-	10	2018	c.1546C>T	c.(1546-1548)Cat>Tat	p.H516Y	MYO9A_ENST00000424560.1_Missense_Mutation_p.H516Y|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000564571.1_Missense_Mutation_p.H516Y|MYO9A_ENST00000444904.1_Missense_Mutation_p.H497Y|MYO9A_ENST00000566885.1_Missense_Mutation_p.H111Y|RP11-390D11.1_ENST00000568391.1_RNA	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	516	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AGAAGTGCATGATTAATTCGA	0.338000													52	123					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	63974589	63974589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:63974589G>A	ENST00000324472.4	-	19	1936	c.1753C>T	c.(1753-1755)Cgt>Tgt	p.R585C	DPY19L2_ENST00000413230.2_Missense_Mutation_p.R32C	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	585					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TTCTCAAAACGAACTCTGCGA	0.358000													13	59					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18767566	18767566	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18767566T>G	ENST00000304081.4	-	3	312	c.212A>C	c.(211-213)aAg>aCg	p.K71T	NT5C1B_ENST00000460052.1_5'UTR|NT5C1B_ENST00000359846.2_Missense_Mutation_p.K131T|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.K131T|NT5C1B_ENST00000600945.1_Missense_Mutation_p.K131T	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GGATGGAGCCTTGGTGGATGG	0.468000													30	89					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5744379	5744379	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5744379G>A	ENST00000546188.1	-	17	1829	c.1758C>T	c.(1756-1758)ctC>ctT	p.L586L	ANO2_ENST00000356134.5_Silent_p.L586L|ANO2_ENST00000327087.8_Silent_p.L585L			Q9NQ90	ANO2_HUMAN	anoctamin 2	590						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GGATGACCACGAGGTTGATGA	0.532000													5	18					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11216169	11216169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11216169C>T	ENST00000558518.1	+	4	774	c.587C>T	c.(586-588)cCc>cTc	p.P196L	LDLR_ENST00000545707.1_Intron|LDLR_ENST00000558013.1_Missense_Mutation_p.P196L|LDLR_ENST00000535915.1_Missense_Mutation_p.P155L|LDLR_ENST00000455727.2_Intron|LDLR_ENST00000557933.1_Missense_Mutation_p.P196L	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	196	LDL-receptor class A 5.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GACAGTAGCCCCTGCTCGGCC	0.617000													26	50					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7847181	7847181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7847181G>A	ENST00000328375.1	-	1	338	c.339C>T	c.(337-339)ttC>ttT	p.F113F	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAGCCAGCAGGAAGCACTCGG	0.547000													38	111					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13701506	13701506	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13701506C>T	ENST00000265104.4	-	77	13482	c.13378G>A	c.(13378-13380)Gaa>Aaa	p.E4460K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4460					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCTATAAGTTCAGTAAACCAG	0.393000									Kartagener syndrome				16	109					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63851848	63851848	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:63851848C>T	ENST00000279873.7	+	10	3036	c.2626C>T	c.(2626-2628)Caa>Taa	p.Q876*	ARID5B_ENST00000309334.5_Nonsense_Mutation_p.Q633*	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	876					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CCACAGACACCAAGAAAAGCT	0.483000													37	113					0	0	1	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998398	8998398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8998398G>A	ENST00000310455.3	-	2	914	c.764C>T	c.(763-765)tCc>tTc	p.S255F	PPP1R3B_ENST00000519699.1_Missense_Mutation_p.S255F	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	255					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		CTGGTCAAAGGATATTCCCAA	0.498000													12	70					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256494	63256494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:63256494C>T	ENST00000323865.3	-	1	1286	c.1053G>A	c.(1051-1053)atG>atA	p.M351I	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	351					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGAAGGTGCCCATGATGATGC	0.597000													21	155					0	0	1	0	0
S100A3	6274	broad.mit.edu	37	1	153520175	153520175	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153520175G>A	ENST00000368713.3	-	3	485	c.289C>T	c.(289-291)Ccc>Tcc	p.P97S	S100A3_ENST00000368712.1_Missense_Mutation_p.P97S|S100A4_ENST00000368714.1_Intron	NM_002960.1	NP_002951.1	P33764	S10A3_HUMAN	S100 calcium binding protein A3	97							calcium ion binding|protein binding			breast(1)|liver(1)|lung(1)	3	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGCAGGGGGGCTCTGAGGGG	0.622000													27	83					0	0	1	0	0
WDR5	11091	broad.mit.edu	37	9	137007496	137007496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137007496C>T	ENST00000358625.3	+	6	567	c.396C>T	c.(394-396)gtC>gtT	p.V132V	WDR5_ENST00000425041.1_Silent_p.V132V	NM_017588.2	NP_060058.1	P61964	WDR5_HUMAN	WD repeat domain 5	132					histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	9		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		GTAATTATGTCTTTTGCTGCA	0.468000													30	74					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962038	10962038	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10962038G>A	ENST00000240691.2	-	1	729	c.637C>T	c.(637-639)Cga>Tga	p.R213*		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	213					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GCATGCAGTCGAATCTGCTTG	0.488000													19	51					0	0	1	0	0
IQCF1	132141	broad.mit.edu	37	3	51928921	51928921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51928921G>A	ENST00000310914.5	-	4	665	c.603C>T	c.(601-603)ttC>ttT	p.F201F		NM_152397.2	NP_689610.2	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	201										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCTTTATTGAGAAGGGAATAC	0.483000													14	61					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219423367	219423367	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219423367G>A	ENST00000258399.3	-	4	422	c.10C>T	c.(10-12)Ctg>Ttg	p.L4L	USP37_ENST00000338465.5_Silent_p.L4L|USP37_ENST00000415516.1_Intron|USP37_ENST00000418019.1_Silent_p.L4L|USP37_ENST00000454775.1_Silent_p.L4L	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	4					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TGTATCTTCAGAGGAGACATA	0.323000													50	113					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43918846	43918846	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43918846G>A	ENST00000261488.6	-	9	1441	c.864C>T	c.(862-864)tcC>tcT	p.S288S	ENOX1_ENST00000540032.1_Silent_p.S101S|ENOX1_ENST00000412891.1_Silent_p.S288S	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	288					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GTTCAATCCAGGAAAGCAGCA	0.458000													18	104					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10242054	10242054	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10242054G>A	ENST00000256458.4	+	3	369	c.277_splice	c.e3-1	p.W93_splice		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	93	Death.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						TGTTTTCAGGGAAACCGGCTC	0.478000													42	145					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40030593	40030593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40030593C>T	ENST00000336649.4	+	7	604	c.604C>T	c.(604-606)Ctc>Ttc	p.L202F	CACNA1I_ENST00000407673.1_Missense_Mutation_p.L202F|CACNA1I_ENST00000404898.1_Missense_Mutation_p.L202F|CACNA1I_ENST00000402142.3_Missense_Mutation_p.L202F|CACNA1I_ENST00000401624.1_Missense_Mutation_p.L202F|CACNA1I_ENST00000400164.3_Missense_Mutation_p.L202F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	202					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGTGAACCTGCTCCTGGACAC	0.567000													61	209					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14748569	14748569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14748569G>A	ENST00000380881.4	-	32	6444	c.5629C>T	c.(5629-5631)Ctg>Ttg	p.L1877L	FREM1_ENST00000380894.1_Silent_p.L412L|FREM1_ENST00000380880.3_Silent_p.L1876L|FREM1_ENST00000422223.2_Silent_p.L1876L			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1876					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GGGGGCAGCAGATGCCAAATG	0.527000													51	164					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214727255	214727255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:214727255G>A	ENST00000331683.5	+	11	1212	c.1117G>A	c.(1117-1119)Gac>Aac	p.D373N	SPAG16_ENST00000374309.3_Missense_Mutation_p.D279N	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	373					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTGTGGCGAGGACCGACTCTG	0.502000													31	79					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102089764	102089764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102089764C>T	ENST00000318222.3	-	1	479	c.97G>A	c.(97-99)Ggg>Agg	p.G33R	PKD2L1_ENST00000353274.3_Missense_Mutation_p.G33R|PKD2L1_ENST00000338519.3_Missense_Mutation_p.G33R	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	33					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CTCAGCGTCCCGTGTGGGGAA	0.632000													39	73					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102290667	102290667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:102290667C>T	ENST00000370103.4	-	4	720	c.507G>A	c.(505-507)gaG>gaA	p.E169E	OLFM3_ENST00000359814.3_Silent_p.E189E|OLFM3_ENST00000338858.5_Silent_p.E189E|OLFM3_ENST00000536598.1_Silent_p.E94E|OLFM3_ENST00000462354.1_5'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	189						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CACCAATTTCCTCCTGAATAC	0.438000													9	52					0	0	1	0	0
LIN52	91750	broad.mit.edu	37	14	74562682	74562682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74562682C>T	ENST00000555028.1	+	3	305	c.138C>T	c.(136-138)ttC>ttT	p.F46F	LIN52_ENST00000554076.1_3'UTR	NM_001024674.2	NP_001019845.1	Q52LA3	LIN52_HUMAN	lin-52 homolog (C. elegans)	46										breast(1)|endometrium(2)|lung(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.00471)		CAGCTTCCTTCAAAAGTGTAA	0.313000													11	27					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72344498	72344498	+	Missense_Mutation	SNP	C	C	T	rs77006793	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:72344498C>T	ENST00000299687.5	+	1	1523	c.1523C>T	c.(1522-1524)cCt>cTt	p.P508L	ZNF407_ENST00000309902.6_Missense_Mutation_p.P508L|ZNF407_ENST00000582337.1_Missense_Mutation_p.P508L|ZNF407_ENST00000577538.1_Missense_Mutation_p.P508L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGTGCCCGTCCTCCGGACTCC	0.572000													37	95					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141734499	141734499	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141734499G>A	ENST00000475668.2	+	16	1871	c.1817G>A	c.(1816-1818)aGa>aAa	p.R606K	MGAM_ENST00000549489.2_Missense_Mutation_p.R606K			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	606	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.R606T(3)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTAATAAGAGAAGCTTCATT	0.502000													9	32					0	0	1	0	0
ZNF200	7752	broad.mit.edu	37	16	3274511	3274511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3274511G>A	ENST00000431561.3	-	5	1181	c.569C>T	c.(568-570)tCc>tTc	p.S190F	ZNF200_ENST00000396870.4_Missense_Mutation_p.S189F|ZNF200_ENST00000575948.1_Missense_Mutation_p.S189F|AJ003147.9_ENST00000576468.1_RNA|ZNF200_ENST00000396868.3_Missense_Mutation_p.S189F|ZNF200_ENST00000414144.2_Missense_Mutation_p.S190F|ZNF200_ENST00000396871.4_Missense_Mutation_p.S189F	NM_001145447.1|NM_003454.3	NP_001138919.1|NP_003445.2	P98182	ZN200_HUMAN	zinc finger protein 200	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	17						AGAGACCAAGGAAGAATCCAT	0.398000													33	60					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647772	51647772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51647772G>A	ENST00000317643.6	+	2	612	c.543G>A	c.(541-543)atG>atA	p.M181I	SIGLEC7_ENST00000600577.1_Intron|SIGLEC7_ENST00000305628.7_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	181	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CGCCCCCTATGATCTCCTGGA	0.652000													45	165					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105353206	105353206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105353206C>T	ENST00000453495.1	+	12	2861	c.2633C>T	c.(2632-2634)cCc>cTc	p.P878L	CEP170B_ENST00000414716.3_Missense_Mutation_p.P877L|CEP170B_ENST00000556508.1_Missense_Mutation_p.P807L|CEP170B_ENST00000418279.1_Missense_Mutation_p.P807L					centrosomal protein 170B																		GCCAGTGGTCCCCCAGCGCCC	0.677000													15	47					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565171	20565171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20565171C>T	ENST00000329697.6	-	5	836	c.668G>A	c.(667-669)gGg>gAg	p.G223E	ACSM2B_ENST00000565322.1_Missense_Mutation_p.G144E|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G223E|ACSM2B_ENST00000565232.1_Missense_Mutation_p.G223E	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	223					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						ACCACTGGTCCCACTAGTGAA	0.512000													11	89					0	0	1	0	0
MMP19	4327	broad.mit.edu	37	12	56235011	56235011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56235011C>T	ENST00000322569.4	-	3	274	c.183G>A	c.(181-183)caG>caA	p.Q61Q	MMP19_ENST00000409200.3_Silent_p.Q61Q|MMP19_ENST00000547487.1_5'UTR|MMP19_ENST00000548629.1_Silent_p.Q61Q	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	61					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						CAGATGCTTCCTGAAAAGCTC	0.527000													22	57					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73068427	73068427	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73068427G>A	ENST00000429829.1	-	0	4161					NR_001564.2																						CCTTTCTAATGGACAGGACTC	0.433000													9	5					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634419	70634419	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70634419A>G	ENST00000381269.2	-	2	1474	c.721T>C	c.(721-723)Ttt>Ctt	p.F241L	SLC8A3_ENST00000528359.1_Missense_Mutation_p.F241L|SLC8A3_ENST00000357887.3_Missense_Mutation_p.F241L|SLC8A3_ENST00000534137.1_Missense_Mutation_p.F241L|SLC8A3_ENST00000356921.2_Missense_Mutation_p.F241L	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	241					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CACACTGGAAAGAAGAAGAGA	0.483000													18	42					0	0	1	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44420687	44420687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44420687G>A	ENST00000372622.3	+	1	112	c.44G>A	c.(43-45)gGg>gAg	p.G15E		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	15						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				GGACCTAGCGGGGCCGAGAGG	0.756000													4	11					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238256999	238256999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238256999C>T	ENST00000295550.4	-	30	7411	c.6959G>A	c.(6958-6960)gGa>gAa	p.G2320E	COL6A3_ENST00000353578.4_Missense_Mutation_p.G2114E|COL6A3_ENST00000409809.1_Missense_Mutation_p.G2114E|COL6A3_ENST00000472056.1_Missense_Mutation_p.G1713E|COL6A3_ENST00000346358.4_Missense_Mutation_p.G2120E|COL6A3_ENST00000347401.3_Missense_Mutation_p.G2119E	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2320	Collagen-like 5.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TACCTTTGGTCCTGGGTATCC	0.363000													36	98					0	0	1	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72958208	72958208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72958208G>A	ENST00000421285.3	+	16	1782	c.1782G>A	c.(1780-1782)caG>caA	p.Q594Q		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	594										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						GGCTGGCCCAGAAGGAGGAGG	0.627000													45	272					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132471171	132471171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:132471171C>T	ENST00000333577.4	+	7	2259	c.2150C>T	c.(2149-2151)tCc>tTc	p.S717F	EP400_ENST00000330386.6_Missense_Mutation_p.S681F|EP400_ENST00000389562.2_Missense_Mutation_p.S680F|EP400_ENST00000332482.4_Missense_Mutation_p.S644F|EP400_ENST00000389561.2_Missense_Mutation_p.S681F			Q96L91	EP400_HUMAN	E1A binding protein p400	717					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCAGGACCCTCCCCTGCTCGA	0.652000													41	55					0	0	1	0	0
C19orf57	79173	broad.mit.edu	37	19	14001207	14001207	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14001207G>A	ENST00000454313.1	-	6	520	c.462C>T	c.(460-462)ccC>ccT	p.P154P	C19orf57_ENST00000346736.2_Silent_p.P154P|C19orf57_ENST00000591586.1_Intron|C19orf57_ENST00000586783.1_Silent_p.P154P			Q0VDD7	CS057_HUMAN	chromosome 19 open reading frame 57	154					multicellular organismal development		protein binding			breast(2)|kidney(1)|lung(3)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CCTCCTGGAGGGGGACCCCCA	0.682000													22	48					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530017	140530017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140530017C>T	ENST00000231136.1	+	1	179	c.179C>T	c.(178-180)tCg>tTg	p.S60L	PCDHB6_ENST00000543635.1_Intron	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		60	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCTGGCTTCGCGGGGCGCT	0.507000													49	109					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176915071	176915071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176915071C>T	ENST00000367654.2	-	13	2277	c.2264G>A	c.(2263-2265)gGa>gAa	p.G755E	ASTN1_ENST00000424564.2_Missense_Mutation_p.G747E|ASTN1_ENST00000367657.3_Missense_Mutation_p.G747E|ASTN1_ENST00000361833.2_Missense_Mutation_p.G747E|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	755					cell migration|neuron cell-cell adhesion	integral to membrane		p.Q743fs*11(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CCTGAATGTTCCTTTCAGCAC	0.438000													61	133					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227192761	227192761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:227192761G>A	ENST00000366769.3	-	34	6095	c.4804C>T	c.(4804-4806)Cca>Tca	p.P1602S	CDC42BPA_ENST00000366766.2_Missense_Mutation_p.P1637S|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.P1664S|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.P1574S|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.P1582S|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.P1521S|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.P1615S	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1615					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				GTGATAGATGGAATACTGACT	0.517000													28	99					0	0	1	0	0
PLOD2	5352	broad.mit.edu	37	3	145806495	145806495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:145806495G>A	ENST00000282903.5	-	9	1060	c.883C>T	c.(883-885)Cat>Tat	p.H295Y	PLOD2_ENST00000360060.3_Missense_Mutation_p.H295Y|RP11-274H2.2_ENST00000480247.1_RNA|PLOD2_ENST00000494950.1_Missense_Mutation_p.H240Y	NM_182943.2	NP_891988.1	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	295					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29					Vitamin C(DB00126)	ACGTTTGGATGGACCTTTGTT	0.308000													9	52					0	0	1	0	0
KDM5C	8242	broad.mit.edu	37	X	53223912	53223912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:53223912G>A	ENST00000452825.3	-	21	3778	c.3246C>T	c.(3244-3246)gcC>gcT	p.A1082A	KDM5C_ENST00000375379.3_Silent_p.A1149A|KDM5C_ENST00000404049.3_Silent_p.A1148A|KDM5C_ENST00000375401.3_Silent_p.A1149A|KDM5C_ENST00000375383.3_Silent_p.A1108A	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	1149					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CCTCCTTGAAGGCCACGATCT	0.612000			"""N, F, S"""		clear cell renal carcinoma								10	12					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23892849	23892849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23892849G>A	ENST00000355349.3	-	24	3168	c.3006C>T	c.(3004-3006)gcC>gcT	p.A1002A		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1002					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCTGTTGGTGGGCCTCTTGCA	0.537000													64	169					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681286	100681286	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100681286G>A	ENST00000306151.4	+	3	6653	c.6589G>A	c.(6589-6591)Gaa>Aaa	p.E2197K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2197	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAATTCTACTGAAGCCCGTTC	0.498000													205	508					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84456240	84456240	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84456240C>T	ENST00000416219.2	+	9	869	c.780C>T	c.(778-780)gtC>gtT	p.V260V	ATP2C2_ENST00000262429.4_Silent_p.V260V|ATP2C2_ENST00000420010.2_3'UTR			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	260					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						CACAGGGGGTCGTGATTGGAA	0.567000													47	245					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337662	102337662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:102337662C>T	ENST00000369138.1	+	11	2162	c.1672C>T	c.(1672-1674)Cct>Tct	p.P558S	GRIK2_ENST00000413795.1_Missense_Mutation_p.P558S|GRIK2_ENST00000369134.4_Missense_Mutation_p.P509S|GRIK2_ENST00000369137.3_Intron|GRIK2_ENST00000318991.6_Missense_Mutation_p.P558S|GRIK2_ENST00000421544.1_Missense_Mutation_p.P558S	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	558					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CTTCCTGAATCCTCTCTCCCC	0.448000													62	119					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83935804	83935804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83935804G>A	ENST00000345382.2	-	3	304	c.219C>T	c.(217-219)atC>atT	p.I73I	BNC1_ENST00000569704.1_Silent_p.I66I|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	73					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						ACATGGGGGGGATCCTTAGCT	0.423000													13	43					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168108280	168108280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168108280G>A	ENST00000409195.1	+	9	10467	c.10378G>A	c.(10378-10380)Gat>Aat	p.D3460N	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D3460N|XIRP2_ENST00000409273.1_Missense_Mutation_p.D3238N|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3285					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AACCTATGAGGATGTCATTGC	0.398000													16	44					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500731	90500731	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90500731C>T	ENST00000325643.5	+	4	1395	c.1329C>T	c.(1327-1329)ctC>ctT	p.L443L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		TCTGGGACCTCCCCTCTCTCA	0.562000													23	182					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96795611	96795611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96795611G>A	ENST00000342380.2	-	8	825	c.826C>T	c.(826-828)Ctc>Ttc	p.L276F		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	276					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						TAGAGTTTGAGGACCCGGGTG	0.647000													9	70					0	0	1	0	0
PDIA4	9601	broad.mit.edu	37	7	148703040	148703040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148703040G>A	ENST00000286091.4	-	8	1469	c.1237C>T	c.(1237-1239)Ccc>Tcc	p.P413S		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	413					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			ACCACCAGGGGGCGCCTGGTG	0.627000											OREG0018420	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	52					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37187987	37187987	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37187987C>T	ENST00000425901.2	+	0	1829					NR_033753.2																						GGTTGTAGCTCAACCTCCTGT	0.498000													10	24					0	0	1	0	0
ZNF155	7711	broad.mit.edu	37	19	44500820	44500820	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44500820C>T	ENST00000270014.2	+	5	939	c.811C>T	c.(811-813)Cat>Tat	p.H271Y	ZNF155_ENST00000590615.1_Missense_Mutation_p.H271Y|ZNF155_ENST00000407951.2_Missense_Mutation_p.H282Y	NM_001260487.1|NM_198089.2	NP_001247416.1|NP_932355.2	Q12901	ZN155_HUMAN	zinc finger protein 155	271						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				GGCCTTCATTCATGATTCCCA	0.393000													71	173					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218274	130218274	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130218274C>A	ENST00000276211.5	+	5	986	c.641C>A	c.(640-642)cCa>cAa	p.P214Q	ARHGAP36_ENST00000370921.1_Missense_Mutation_p.P78Q|ARHGAP36_ENST00000370922.1_Missense_Mutation_p.P202Q	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	214					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						ATTTCCTTTCCAATTGGCCAA	0.498000													4	38					0.00909568	0.00909849	1	1	0
PRDM8	56978	broad.mit.edu	37	4	81123333	81123333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:81123333C>T	ENST00000339711.4	+	10	1948	c.717C>T	c.(715-717)ccC>ccT	p.P239P	PRDM8_ENST00000504452.1_Silent_p.P239P|PRDM8_ENST00000415738.2_Silent_p.P239P	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	239	Gly-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						ACCCATCCCCCTCCCCGGAAA	0.667000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	33					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87967765	87967765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:87967765C>T	ENST00000369577.3	+	8	4461	c.4418C>T	c.(4417-4419)tCt>tTt	p.S1473F	ZNF292_ENST00000339907.4_Missense_Mutation_p.S1468F	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TTTCCTCGATCTGGTGTGACT	0.403000													7	34					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32256892	32256892	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32256892C>T	ENST00000360482.2	-	16	3092	c.2962_splice	c.e16-1	p.G988_splice	SPOCD1_ENST00000533231.1_Intron|SPOCD1_ENST00000373648.2_3'UTR|RP11-84A19.3_ENST00000527035.1_RNA|SPOCD1_ENST00000257100.3_Intron	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	988					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		AGCCCAAAGGCCTGCGGGGAA	0.582000													6	24					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33944535	33944535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33944535G>A	ENST00000379238.1	-	14	1490	c.1373C>T	c.(1372-1374)tCc>tTc	p.S458F	UBAP2_ENST00000379225.1_Missense_Mutation_p.S91F|UBAP2_ENST00000539807.1_Missense_Mutation_p.S213F|UBAP2_ENST00000418786.2_Missense_Mutation_p.S405F|UBAP2_ENST00000449054.1_Missense_Mutation_p.S458F|UBAP2_ENST00000379239.4_Missense_Mutation_p.S191F|UBAP2_ENST00000360802.1_Missense_Mutation_p.S458F			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	458										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GGAAGGAAAGGACTCCAAACC	0.512000													20	38					0	0	1	0	0
HLTF	6596	broad.mit.edu	37	3	148792128	148792128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:148792128G>A	ENST00000310053.5	-	4	596	c.403C>T	c.(403-405)Cct>Tct	p.P135S	HLTF_ENST00000494055.1_Missense_Mutation_p.P135S|HLTF_ENST00000392912.2_Missense_Mutation_p.P135S|HLTF_ENST00000465259.1_Missense_Mutation_p.P135S	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	135					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GCACCAAAAGGAACTACCCTA	0.338000													23	64					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234553868	234553868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:234553868G>A	ENST00000040877.1	-	22	3666	c.3667C>T	c.(3667-3669)Cct>Tct	p.P1223S		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1223					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			AGAAATTGAGGGAATTTATGA	0.284000													7	26					0	0	1	0	0
SLC35G1	159371	broad.mit.edu	37	10	95660812	95660812	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95660812C>T	ENST00000371408.3	+	3	721	c.660C>T	c.(658-660)caC>caT	p.H220H	SLC35G1_ENST00000427197.1_Silent_p.H221H			Q2M3R5	TMM20_HUMAN	solute carrier family 35, member G1	221						integral to membrane											ATTCAGGCCACCTTAAGGGAA	0.443000													36	56					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36181711	36181711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36181711C>T	ENST00000357641.6	+	8	2790	c.2537C>T	c.(2536-2538)tCc>tTc	p.S846F	BRPF3_ENST00000543502.1_Intron|BRPF3_ENST00000534694.1_Intron|BRPF3_ENST00000443324.2_Intron|BRPF3_ENST00000339717.7_Intron|BRPF3_ENST00000534400.1_Missense_Mutation_p.S846F	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	846					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						CCTGCACCTTCCTTGTCTGAG	0.493000													15	148					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64644340	64644340	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:64644340C>T	ENST00000371079.1	+	9	2991	c.2616C>T	c.(2614-2616)ccC>ccT	p.P872P	ROR1_ENST00000545203.1_Silent_p.P323P	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	872	Ser/Thr-rich.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						CTAGCTTGCCCTCATCAGGAT	0.507000													13	52					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53345298	53345298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:53345298C>T	ENST00000226067.5	+	2	775	c.302C>T	c.(301-303)cCa>cTa	p.P101L	HLF_ENST00000430986.2_Missense_Mutation_p.P16L|HLF_ENST00000573945.1_Missense_Mutation_p.P16L|HLF_ENST00000575345.1_Missense_Mutation_p.P16L	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	101					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						CCCCCCAGCCCATCTCAGCAT	0.577000			T	TCF3	ALL								58	145					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27460569	27460569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27460569C>T	ENST00000337929.3	+	9	2055	c.1582C>T	c.(1582-1584)Ccg>Tcg	p.P528S	IL21R_ENST00000564089.1_Missense_Mutation_p.P528S|IL21R-AS1_ENST00000563191.1_RNA|IL21R_ENST00000395755.1_Missense_Mutation_p.P528S|IL21R_ENST00000395754.4_Missense_Mutation_p.P528S	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	528					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						GGTCATTCCTCCGCCACTTTC	0.652000			T	BCL6	NHL								14	49					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27943722	27943722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27943722C>T	ENST00000374005.3	-	6	802	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	FGR_ENST00000399173.1_Missense_Mutation_p.E172K|FGR_ENST00000374004.1_Missense_Mutation_p.E172K|FGR_ENST00000545953.1_Intron	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	172	SH2.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GTCTCGCTTTCCCGAATGAGA	0.592000													30	61					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96609693	96609693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96609693C>T	ENST00000371321.3	+	8	1251	c.1169C>T	c.(1168-1170)tCc>tTc	p.S390F	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	390					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	ATATTAACTTCCCTCACTTCT	0.393000													78	166					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86124798	86124798	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86124798C>T	ENST00000394518.2	+	7	3594	c.3499C>T	c.(3499-3501)Cac>Tac	p.H1167Y	AKAP13_ENST00000361243.2_Missense_Mutation_p.H1167Y	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1167					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GGGAGCAGACCACAGCTGTAC	0.547000													46	55					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38924684	38924684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38924684G>A	ENST00000274276.3	+	14	2433	c.2031G>A	c.(2029-2031)aaG>aaA	p.K677K		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	677	Fibronectin type-III 4.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					GATTTGAAAAGGCAGTTCTTT	0.363000													43	115					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180003	124180003	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124180003G>A	ENST00000357821.2	-	1	730	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TGTAGAGGATGAAGGCATAGG	0.507000													16	32					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7473344	7473344	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7473344G>A	ENST00000399422.4	+	6	993	c.945G>A	c.(943-945)acG>acA	p.T315T		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	315					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						ATCCCATCACGACCCTGTGCA	0.463000													8	27					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135781419	135781419	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135781419G>A	ENST00000298552.3	-	15	1767	c.1546C>T	c.(1546-1548)Cag>Tag	p.Q516*	TSC1_ENST00000545250.1_Nonsense_Mutation_p.Q465*|TSC1_ENST00000440111.2_Nonsense_Mutation_p.Q516*	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	516					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.Q516*(2)|p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GTCTTCCGCTGAGAACCTGGG	0.567000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				14	39					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55733486	55733486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55733486G>A	ENST00000379906.2	+	11	1765	c.1510G>A	c.(1510-1512)Gac>Aac	p.D504N	SLC6A2_ENST00000414754.3_Missense_Mutation_p.D504N|SLC6A2_ENST00000561820.1_Missense_Mutation_p.D504N|SLC6A2_ENST00000568943.1_Missense_Mutation_p.D504N|SLC6A2_ENST00000566163.1_Missense_Mutation_p.D459N|SLC6A2_ENST00000567238.1_Missense_Mutation_p.D399N|SLC6A2_ENST00000219833.8_Missense_Mutation_p.D504N	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	504					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GTTCAGCAACGACATCCAGCA	0.592000													5	49					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50534962	50534962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50534962C>T	ENST00000267845.3	-	12	1886	c.1484G>A	c.(1483-1485)aGg>aAg	p.R495K	HDC_ENST00000543581.1_Missense_Mutation_p.R462K	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	495					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TCTGGCACCCCTGATTTGGGA	0.572000													16	42					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165948992	165948992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165948992C>T	ENST00000360093.3	-	27	5070	c.4579G>A	c.(4579-4581)Gtc>Atc	p.V1527I	SCN3A_ENST00000540861.1_Missense_Mutation_p.V10I|SCN3A_ENST00000283254.7_Missense_Mutation_p.V1527I|SCN3A_ENST00000409101.3_Missense_Mutation_p.V1478I|SCN3A_ENST00000465043.1_5'UTR	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1527						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ATATCAAAGACTTGTCTGGTT	0.383000													20	46					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24527904	24527904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24527904G>A	ENST00000342740.5	+	18	1562	c.1408G>A	c.(1408-1410)Gcc>Acc	p.A470T	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	470										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		TTCAGCGGGAGCCCAAGCCTT	0.592000											OREG0022615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	43					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46888190	46888190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46888190C>T	ENST00000359759.4	+	2	1407	c.1386C>T	c.(1384-1386)ctC>ctT	p.L462L	COL18A1_ENST00000355480.5_Silent_p.L227L|COL18A1_ENST00000400337.2_Silent_p.L47L			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	462	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TGCTGCAGCTCCTTGGGGACC	0.672000													29	71					0	0	1	0	0
THNSL1	79896	broad.mit.edu	37	10	25312259	25312259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25312259C>T	ENST00000524413.1	+	3	454	c.107C>T	c.(106-108)aCc>aTc	p.T36I	THNSL1_ENST00000376356.4_Missense_Mutation_p.T36I			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	36					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	CTTTCAAGAACCTTTGCACTT	0.388000													36	99					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168266990	168266990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168266990C>T	ENST00000367821.3	+	4	683	c.632C>T	c.(631-633)cCt>cTt	p.P211L		NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	211					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					AAGTACAATCCTTTTGCCAAA	0.338000													22	26					0	0	1	0	0
EXOSC10	5394	broad.mit.edu	37	1	11150690	11150690	+	Missense_Mutation	SNP	G	G	A	rs146582265	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11150690G>A	ENST00000544779.1	-	6	684	c.679C>T	c.(679-681)Cgt>Tgt	p.R227C	EXOSC10_ENST00000304457.7_Missense_Mutation_p.R227C|EXOSC10_ENST00000376936.4_Missense_Mutation_p.R227C			Q01780	EXOSX_HUMAN	exosome component 10	227					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		TCCTCAGGACGATCCTGTGGG	0.517000													14	32					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57070091	57070091	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57070091G>A	ENST00000532437.1	-	6	4836	c.4525C>T	c.(4525-4527)Ccg>Tcg	p.P1509S	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.P1509S			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1509	Acidic.|Tankyrase-binding.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				TCAGGCTGCGGCCTCCAGGAG	0.672000													4	26					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49176654	49176654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49176654G>A	ENST00000307885.4	-	1	1258	c.564C>T	c.(562-564)gcC>gcT	p.A188A	ADCY6_ENST00000357869.3_Silent_p.A188A|ADCY6_ENST00000550422.1_Silent_p.A188A	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	188					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CGAACAGGGCGGCGGCACAGG	0.667000													4	56					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63011984	63011984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:63011984C>T	ENST00000561311.1	+	24	3126	c.2896C>T	c.(2896-2898)Cct>Tct	p.P966S	TLN2_ENST00000306829.6_Missense_Mutation_p.P966S			Q9Y4G6	TLN2_HUMAN	talin 2	966	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TGATCACATCCCTCAGCTGGT	0.547000													23	15					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21478757	21478757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21478757G>A	ENST00000313654.9	+	45	5910	c.5669G>A	c.(5668-5670)gGc>gAc	p.G1890D	LAMA3_ENST00000587184.1_Missense_Mutation_p.G281D|LAMA3_ENST00000399516.3_Missense_Mutation_p.G1890D|LAMA3_ENST00000269217.6_Missense_Mutation_p.G281D|LAMA3_ENST00000588770.1_3'UTR	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1890	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAATAGAAGGCCTGGAAAGA	0.348000													25	92					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151259552	151259552	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151259552T>A	ENST00000368879.2	+	2	883	c.785T>A	c.(784-786)tTc>tAc	p.F262Y		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	262	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGGGTGCCCTTCTTCAAGCAG	0.622000													31	124					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117297532	117297532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:117297532G>A	ENST00000369478.3	+	2	449	c.341G>A	c.(340-342)gGa>gAa	p.G114E	CD2_ENST00000369477.1_Missense_Mutation_p.G114E	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	114	Ig-like V-type.|LFA-3 (CD58) binding region 2.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GATACAAAAGGAAAAAATGTG	0.308000													7	45					0	0	1	0	0
LCOR	84458	broad.mit.edu	37	10	98715483	98715483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98715483C>T	ENST00000540664.1	+	8	1649	c.1106C>T	c.(1105-1107)tCc>tTc	p.S369F	LCOR_ENST00000498444.1_Intron|LCOR_ENST00000356016.3_Missense_Mutation_p.S369F|LCOR_ENST00000371103.3_Missense_Mutation_p.S369F|LCOR_ENST00000371097.4_Missense_Mutation_p.S369F	NM_001170765.1|NM_001170766.1	NP_001164236.1|NP_001164237.1			ligand dependent nuclear receptor corepressor											endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|urinary_tract(1)	13		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		ATGAGTGTTTCCAAAGCTCAG	0.438000													26	40					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22364037	22364037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22364037C>T	ENST00000397121.2	-	3	799	c.482G>A	c.(481-483)aGa>aAa	p.R161K		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGTATAAATTCTTTCATGTTG	0.338000													32	84					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136620245	136620245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136620245G>A	ENST00000264156.2	-	8	1212	c.1152C>T	c.(1150-1152)acC>acT	p.T384T	MCM6_ENST00000492091.1_5'UTR	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	384	MCM.			PKTTGEGTSLR -> SKDNRRRDLSS (in Ref. 2; AAC50766).	cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CTCGAAGAGAGGTCCCTTCTC	0.453000													52	116					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76342274	76342274	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76342274C>T	ENST00000312916.7	+	6	1355	c.973C>T	c.(973-975)Cat>Tat	p.H325Y		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	325					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		AATAGGCATTCATCACAAAAA	0.358000													17	215					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44378052	44378052	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44378052C>T	ENST00000587539.1	-	3	313	c.314G>A	c.(313-315)gGa>gAa	p.G105E	ZNF404_ENST00000324394.6_Missense_Mutation_p.G103E	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				ACTAAAACATCCCACTTTAGG	0.328000													40	148					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79341870	79341870	+	Missense_Mutation	SNP	C	C	T	rs150981409	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79341870C>T	ENST00000419573.3	-	4	866	c.592G>A	c.(592-594)Gat>Aat	p.D198N	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.D198N	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	198					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CTGTCTTCATCGTTGGGGGCG	0.557000													13	69					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104075171	104075171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104075171G>A	ENST00000374874.3	+	6	1167	c.728G>A	c.(727-729)gGc>gAc	p.G243D	LPPR1_ENST00000395056.2_Missense_Mutation_p.G243D	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		243						integral to membrane	catalytic activity										TTCCTGACAGGCCTCAACCGG	0.547000													28	115					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141770881	141770881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141770881C>T	ENST00000475668.2	+	44	5203	c.5149C>T	c.(5149-5151)Ctg>Ttg	p.L1717L	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1717	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGGCTACATCCTGCCCTGGCA	0.493000													18	34					0	0	1	0	0
P2RX7	5027	broad.mit.edu	37	12	121593886	121593886	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121593886A>T	ENST00000546057.1	+	3	442	c.299A>T	c.(298-300)aAc>aTc	p.N100I	P2RX7_ENST00000328963.5_5'UTR|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000535250.1_Missense_Mutation_p.N10I|P2RX7_ENST00000377162.2_Missense_Mutation_p.N100I|P2RX7_ENST00000541446.1_5'UTR	NM_002562.5	NP_002553.3	A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	100						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCACAGGGGAACTCTTTCTTC	0.473000													39	95					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181752865	181752865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181752865C>T	ENST00000526775.1	+	39	5523	c.5358C>T	c.(5356-5358)ttC>ttT	p.F1786F	CACNA1E_ENST00000367570.1_Silent_p.F1805F|CACNA1E_ENST00000367567.4_Silent_p.F1412F|CACNA1E_ENST00000360108.3_Silent_p.F1786F|CACNA1E_ENST00000357570.5_Silent_p.F1756F|CACNA1E_ENST00000358338.5_Silent_p.F1737F|CACNA1E_ENST00000367573.2_Silent_p.F1805F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1805					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CGGTCCACTTCACCTCCACAC	0.443000													15	50					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88414169	88414169	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:88414169G>A	ENST00000261304.2	-	13	1498	c.1392C>T	c.(1390-1392)ttC>ttT	p.F464F	GALC_ENST00000544807.2_Silent_p.F408F|GALC_ENST00000393568.4_Silent_p.F441F|GALC_ENST00000393569.2_Silent_p.F438F	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	464					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TGGTGAGTGTGAACAGCTCAT	0.488000													23	73					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39510025	39510025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:39510025G>A	ENST00000537403.1	-	14	2649	c.1447C>T	c.(1447-1449)Ctg>Ttg	p.L483L	SEC23A_ENST00000307712.6_Silent_p.L685L|SEC23A_ENST00000536508.1_Silent_p.L583L|SEC23A_ENST00000545328.2_Silent_p.L656L			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	685					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		GGGGCTTGCAGAAGGTGGCGG	0.418000													22	89					0	0	1	0	0
ING3	54556	broad.mit.edu	37	7	120608053	120608053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120608053C>T	ENST00000315870.5	+	8	770	c.622C>T	c.(622-624)Ctg>Ttg	p.L208L	ING3_ENST00000431467.1_Silent_p.L193L	NM_019071.2	NP_061944.2	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3	208					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			NS(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	12	all_neural(327;0.117)					CTCCCAACCTCTGGGATCCTA	0.428000													25	55					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23239966	23239966	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23239966G>T	ENST00000400191.3	+	16	2882	c.2864G>T	c.(2863-2865)cGg>cTg	p.R955L	EPHB2_ENST00000374632.3_Missense_Mutation_p.R956L|EPHB2_ENST00000374630.3_Missense_Mutation_p.R955L|EPHB2_ENST00000374627.1_3'UTR	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	955	SAM.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GACATTCTCCGGGTTGGGGTC	0.552000													6	38					2.0095e-06	2.01364e-06	1	1	0
DMGDH	29958	broad.mit.edu	37	5	78328593	78328593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78328593C>T	ENST00000255189.3	-	9	1462	c.1434G>A	c.(1432-1434)ctG>ctA	p.L478L	DMGDH_ENST00000380311.4_Silent_p.L277L|DMGDH_ENST00000540686.1_Silent_p.L98L	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	478					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		ACTTAGACTCCAGCCTTTGAT	0.493000													35	191					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17449891	17449891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17449891G>A	ENST00000302539.4	-	14	2110	c.1985C>T	c.(1984-1986)cCa>cTa	p.P662L	ABCC8_ENST00000389817.3_Missense_Mutation_p.P662L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	662					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GCTCTGCAGTGGGCCGGTGAG	0.662000													31	91					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57367553	57367553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57367553G>A	ENST00000403558.1	+	2	721	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K	SERPING1_ENST00000278407.4_Missense_Mutation_p.E85K|SERPING1_ENST00000378324.2_Missense_Mutation_p.E33K|SERPING1_ENST00000340687.6_Missense_Mutation_p.E85K|SERPING1_ENST00000378323.4_Missense_Mutation_p.E90K	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	85	7 X 4 AA tandem repeats of [QE]-P-T-[TQ].		Missing (in HAE; type 2).		blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						taccactgatgaacccaccac	0.527000													6	27					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135369385	135369385	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:135369385C>T	ENST00000368517.3	-	10	648	c.510G>A	c.(508-510)ctG>ctA	p.L170L	SPRN_ENST00000541506.1_Intron|SYCE1_ENST00000432597.2_Silent_p.L170L|SYCE1_ENST00000343131.5_Silent_p.L206L	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	206					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TCACGTCTTCCAGTGTCGCCT	0.607000													17	30					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144944640	144944640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144944640C>T	ENST00000525985.1	-	2	2853	c.2782G>A	c.(2782-2784)Ggc>Agc	p.G928S				P58107	EPIPL_HUMAN	epiplakin 1	928						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTCCCAGGCCGCACAGGTAC	0.682000													7	28					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204944445	204944445	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204944445G>A	ENST00000367172.4	+	15	1933	c.1605G>A	c.(1603-1605)agG>agA	p.R535R	NFASC_ENST00000513543.1_Silent_p.R546R|NFASC_ENST00000338586.6_Silent_p.R535R|NFASC_ENST00000367169.4_Silent_p.R535R|NFASC_ENST00000360049.4_Silent_p.R546R|NFASC_ENST00000367171.4_Silent_p.R535R|NFASC_ENST00000401399.1_Silent_p.R535R|NFASC_ENST00000539706.1_Silent_p.R546R|NFASC_ENST00000403080.1_Silent_p.R535R|NFASC_ENST00000367170.4_Silent_p.R535R|NFASC_ENST00000339876.6_Silent_p.R535R|NFASC_ENST00000404907.1_Silent_p.R546R|NFASC_ENST00000404076.1_Silent_p.R529R|NFASC_ENST00000338515.6_Silent_p.R535R			O94856	NFASC_HUMAN	neurofascin	535	Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGGCCAGAAGGGGCACCACGG	0.622000											OREG0014142	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	104					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74414831	74414831	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:74414831G>A	ENST00000263665.6	-	8	996	c.969C>T	c.(967-969)ctC>ctT	p.L323L		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	323	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CATCCTTTATGAGTTGAACCC	0.398000													74	234					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48165182	48165182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48165182C>T	ENST00000320031.8	+	24	3324	c.2994C>T	c.(2992-2994)gcC>gcT	p.A998A	ITGA3_ENST00000007722.7_Silent_p.A998A	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	998					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						TGCTGGTGGCCGTGGGTGCAG	0.642000													7	11					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131283082	131283082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:131283082C>T	ENST00000512055.1	-	15	3165	c.1039G>A	c.(1039-1041)Gag>Aag	p.E347K	CPNE4_ENST00000512332.1_Missense_Mutation_p.E365K|CPNE4_ENST00000502818.1_Missense_Mutation_p.E365K|CPNE4_ENST00000429747.1_Missense_Mutation_p.E347K|CPNE4_ENST00000511604.1_Missense_Mutation_p.E347K			Q96A23	CPNE4_HUMAN	copine IV	347	VWFA.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						TGGCAAATCTCCCCCACAGCT	0.502000													37	72					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848186	215848186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215848186G>A	ENST00000366943.2	-	63	13453	c.13067C>T	c.(13066-13068)cCa>cTa	p.P4356L	USH2A_ENST00000307340.3_Missense_Mutation_p.P4356L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4356	Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GACTTCTGATGGAGCAGCCTC	0.498000										HNSCC(13;0.011)			15	82					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21478756	21478756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21478756G>A	ENST00000313654.9	+	45	5909	c.5668G>A	c.(5668-5670)Ggc>Agc	p.G1890S	LAMA3_ENST00000587184.1_Missense_Mutation_p.G281S|LAMA3_ENST00000399516.3_Missense_Mutation_p.G1890S|LAMA3_ENST00000269217.6_Missense_Mutation_p.G281S|LAMA3_ENST00000588770.1_3'UTR	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1890	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAAATAGAAGGCCTGGAAAG	0.348000													25	91					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804214	115804214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115804214G>A	ENST00000369295.2	+	1	409	c.323G>A	c.(322-324)gGg>gAg	p.G108E		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	108					positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	CTGGTCATGGGGCTGCTGGTG	0.657000													38	75					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64825982	64825982	+	Silent	SNP	C	C	T	rs142141446		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64825982C>T	ENST00000358658.3	-	1	39	c.12G>A	c.(10-12)acG>acA	p.T4T	NAALADL1_ENST00000339885.2_Silent_p.T4T|NAALADL1_ENST00000355721.3_Silent_p.T4T|NAALADL1_ENST00000356632.3_Silent_p.T4T|NAALADL1_ENST00000355369.2_Silent_p.T4T|NAALADL1_ENST00000340252.4_Silent_p.T4T	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	4					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CCAACACCTTCGTCCACTGCA	0.592000													7	15					0	0	1	0	0
SHKBP1	92799	broad.mit.edu	37	19	41086272	41086272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41086272C>T	ENST00000291842.5	+	7	492	c.443C>T	c.(442-444)cCt>cTt	p.P148L	SHKBP1_ENST00000600733.1_Missense_Mutation_p.P148L	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	148						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTAGTGGGGCCTCAGCAGCTA	0.582000													13	41					0	0	1	0	0
CD226	10666	broad.mit.edu	37	18	67540457	67540457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:67540457G>A	ENST00000280200.4	-	5	1021	c.753C>T	c.(751-753)ctC>ctT	p.L251L	CD226_ENST00000577287.1_Silent_p.L96L|CD226_ENST00000582621.1_Silent_p.L251L|CD226_ENST00000581982.1_Silent_p.L96L	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	251					cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				CAGCCACAAAGAGGGTATATT	0.363000													63	137					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703723	4703723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4703723G>A	ENST00000396950.3	-	2	458	c.219C>T	c.(217-219)tcC>tcT	p.S73S		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGTGGATGTGGATAAGGCCA	0.502000													24	70					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142500312	142500312	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142500312C>T	ENST00000430863.1	-	0	682					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CACCACCCGCCACGAGTGCCT	0.652000													8	32					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103571339	103571339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103571339G>A	ENST00000380069.3	+	6	1472	c.1396G>A	c.(1396-1398)Gct>Act	p.A466T		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	466										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						GTTTGAAAAGGCTTTTCTGGC	0.657000											OREG0022947	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	60					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237863598	237863598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237863598G>A	ENST00000366574.2	+	65	9515	c.9198G>A	c.(9196-9198)gaG>gaA	p.E3066E	RYR2_ENST00000542537.1_Silent_p.E3050E|RYR2_ENST00000360064.6_Silent_p.E3064E	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3066					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGCTGCAGAGGATCTGGAGA	0.483000													4	9					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59878805	59878805	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59878805G>A	ENST00000259008.2	-	8	1216	c.949C>T	c.(949-951)Cat>Tat	p.H317Y	BRIP1_ENST00000577598.1_Missense_Mutation_p.H317Y	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	317	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						CTAATTTTATGAACTCCATGA	0.368000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					21	165					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43314241	43314241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43314241C>T	ENST00000321925.4	+	5	576	c.344C>T	c.(343-345)tCa>tTa	p.S115L	SLC14A1_ENST00000586142.1_Missense_Mutation_p.S115L|SLC14A1_ENST00000502059.2_Missense_Mutation_p.S7L|RP11-116O18.3_ENST00000586213.1_RNA|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000436407.3_Missense_Mutation_p.S171L|SLC14A1_ENST00000415427.3_Missense_Mutation_p.S171L|SLC14A1_ENST00000535474.1_5'UTR|SLC14A1_ENST00000402943.2_Missense_Mutation_p.S10L|SLC14A1_ENST00000589700.1_Missense_Mutation_p.S115L|SLC14A1_ENST00000591943.1_3'UTR	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	115						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						CCCCACAGGTCATTAATAGCA	0.463000													48	112					0	0	1	0	0
RINT1	60561	broad.mit.edu	37	7	105190518	105190518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:105190518C>T	ENST00000257700.2	+	8	1244	c.1013C>T	c.(1012-1014)gCt>gTt	p.A338V		NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	338	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						TGGTACTTGGCTCAAGTACTT	0.348000													24	63					0	0	1	0	0
SH3BP2	6452	broad.mit.edu	37	4	2829023	2829023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:2829023C>T	ENST00000442312.2	+	6	758	c.579C>T	c.(577-579)tcC>tcT	p.S193S	SH3BP2_ENST00000452765.2_Silent_p.S165S|SH3BP2_ENST00000511747.1_Silent_p.S165S|SH3BP2_ENST00000435136.2_Silent_p.S165S|SH3BP2_ENST00000503393.2_Silent_p.S222S|SH3BP2_ENST00000515183.1_3'UTR|SH3BP2_ENST00000356331.5_Silent_p.S165S	NM_001145855.1	NP_001139327.1	P78314	3BP2_HUMAN	SH3-domain binding protein 2	165					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		TCAGCCTTTCCCCGTACCCCA	0.627000									Cherubism				23	58					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66075971	66075971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:66075971C>T	ENST00000349533.6	+	14	2172	c.1987C>T	c.(1987-1989)Ctt>Ttt	p.L663F	LEPR_ENST00000371058.1_Missense_Mutation_p.L663F|LEPR_ENST00000371059.3_Missense_Mutation_p.L663F|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371060.3_Missense_Mutation_p.L663F|LEPR_ENST00000344610.8_Missense_Mutation_p.L663F	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	663	Fibronectin type-III 3.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGTCACTTTACTTTGGAAGGT	0.284000													7	50					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198687314	198687314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:198687314C>T	ENST00000367376.2	+	14	1707	c.1536C>T	c.(1534-1536)ccC>ccT	p.P512P	PTPRC_ENST00000352140.3_Silent_p.P464P|PTPRC_ENST00000348564.6_Silent_p.P353P|PTPRC_ENST00000442510.2_Silent_p.P514P|PTPRC_ENST00000594404.1_Silent_p.P351P	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	512	Fibronectin type-III 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GTAATGGCCCCCATGAACGTT	0.428000													19	55					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92150276	92150276	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92150276C>T	ENST00000256343.3	-	11	1032	c.876G>A	c.(874-876)gtG>gtA	p.V292V		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	292					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GTTTTCCTTTCACATAGTCAA	0.259000													31	86					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42482862	42482862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42482862G>A	ENST00000545399.1	-	12	1718	c.1565C>T	c.(1564-1566)tCc>tTc	p.S522F	ATP1A3_ENST00000302102.5_Missense_Mutation_p.S509F|ATP1A3_ENST00000602133.1_Missense_Mutation_p.S479F|ATP1A3_ENST00000543770.1_Missense_Mutation_p.S520F	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	509					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CAGGATGGTGGAGCAGCGGTC	0.627000													43	86					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28260212	28260212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28260212C>T	ENST00000305242.5	-	8	1059	c.967G>A	c.(967-969)Gaa>Aaa	p.E323K	ARMC4_ENST00000537576.1_Missense_Mutation_p.E15K|ARMC4_ENST00000545014.1_Intron|ARMC4_ENST00000239715.3_Missense_Mutation_p.E180K|ARMC4_ENST00000480504.1_5'UTR	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	323							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TGATCCTTTTCCTTTTGCTGG	0.388000													21	53					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60702830	60702830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60702830C>T	ENST00000005286.4	+	10	2099	c.1946C>T	c.(1945-1947)tCg>tTg	p.S649L	TMEM132A_ENST00000453848.2_Missense_Mutation_p.S648L	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	648	Binds to HSPA5/GRP78 (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						ATGGGCATCTCGCTGACCTTG	0.662000													7	26					0	0	1	0	0
FBXW2	26190	broad.mit.edu	37	9	123550268	123550268	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123550268A>C	ENST00000373926.3	-	3	456	c.269T>G	c.(268-270)gTg>gGg	p.V90G	FBXW2_ENST00000340778.5_Missense_Mutation_p.V90G	NM_012164.3	NP_036296.2	Q9UKT8	FBXW2_HUMAN	F-box and WD repeat domain containing 2	90	F-box.				proteolysis		protein binding|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	4						GGCACTTATCACCTTATTCCA	0.443000													37	108					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68780337	68780337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68780337C>T	ENST00000508048.1	-	9	1096	c.1061G>A	c.(1060-1062)gGa>gAa	p.G354E	TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.G355E|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.G358E			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	358	Peptidase S1.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TTCCATATATCCGGCACAGAA	0.368000													53	129					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89381960	89381960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89381960C>T	ENST00000439576.2	+	3	511	c.137C>T	c.(136-138)tCc>tTc	p.S46F	ACAN_ENST00000558207.1_Missense_Mutation_p.S46F|ACAN_ENST00000352105.7_Missense_Mutation_p.S46F|ACAN_ENST00000559004.1_Missense_Mutation_p.S46F|ACAN_ENST00000561243.1_Missense_Mutation_p.S46F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	46					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGGGACCTCCCTCACCATC	0.622000													37	118					0	0	1	0	0
CD8A	925	broad.mit.edu	37	2	87013055	87013055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:87013055C>T	ENST00000409511.2	-	9	1726	c.696G>A	c.(694-696)gcG>gcA	p.A232A	CD8A_ENST00000352580.3_Silent_p.A195A|CD8A_ENST00000409781.1_Silent_p.A195A|CD8A_ENST00000456996.2_Silent_p.A195A|CD8A_ENST00000283635.3_Silent_p.A232A|CD8A_ENST00000538832.1_Silent_p.A273A	NM_001145873.1	NP_001139345.1	P01732	CD8A_HUMAN	CD8a molecule	232					antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	8						AGACGTATCTCGCCGAAAGGC	0.507000													60	168					0	0	1	0	0
LINC00661	126536	broad.mit.edu	37	19	16131426	16131426	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16131426C>T	ENST00000549354.1	+	0	257				AC004790.3_ENST00000592886.1_lincRNA	NR_026828.1																						CATCAGTGCCCTGGAAGTGAA	0.627000													12	29					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130511741	130511741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130511741G>A	ENST00000314830.8	-	5	1001	c.888C>T	c.(886-888)ctC>ctT	p.L296L	SH2D3C_ENST00000420366.1_Silent_p.L138L|SH2D3C_ENST00000373274.3_Silent_p.L136L|SH2D3C_ENST00000373276.3_Silent_p.L228L|SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Silent_p.L139L|SH2D3C_ENST00000429553.1_5'UTR	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	296	SH2.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GATAGCGCACGAGGGCGGGCA	0.587000													7	59					0	0	1	0	0
STXBP4	252983	broad.mit.edu	37	17	53120603	53120603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:53120603C>T	ENST00000376352.2	+	11	1069	c.862C>T	c.(862-864)Cct>Tct	p.P288S	STXBP4_ENST00000299341.4_Missense_Mutation_p.P213S|STXBP4_ENST00000434978.2_Missense_Mutation_p.P288S|STXBP4_ENST00000398391.2_Missense_Mutation_p.P213S|STXBP4_ENST00000405898.1_Missense_Mutation_p.P288S	NM_178509.5	NP_848604.3	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	288						cytoplasm	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19						ATAGCTTCTTCCTTGTGATTC	0.323000													7	22					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89521887	89521887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89521887C>T	ENST00000370473.4	-	8	1399	c.1180G>A	c.(1180-1182)Gac>Aac	p.D394N		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	394					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TTACAAAAGTCATCCCGCTTT	0.393000													45	140					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113388767	113388767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113388767C>T	ENST00000228928.7	+	7	1823	c.1644C>T	c.(1642-1644)gcC>gcT	p.A548A	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	548	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						TGCTGCCTGCCTTCGATGCTG	0.597000													6	45					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52942138	52942138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52942138C>T	ENST00000332323.6	+	4	1525	c.1464C>T	c.(1462-1464)ttC>ttT	p.F488F	ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Silent_p.F475F|ZNF534_ENST00000301085.4_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						GCAAGGTCTTCAGTCAGAATT	0.418000													9	19					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55175726	55175726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55175726G>A	ENST00000421030.2	+	24	4123	c.3838G>A	c.(3838-3840)Ggg>Agg	p.G1280R	MROH7_ENST00000414150.2_Intron|MROH7_ENST00000409996.1_Missense_Mutation_p.G848R|MROH7_ENST00000454855.2_Missense_Mutation_p.G798R	NM_001039464.2	NP_001034553.2			maestro heat-like repeat family member 7																		GCTGCCGCACGGGAACTCATG	0.617000													9	50					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34004133	34004133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34004133G>A	ENST00000374181.3	-	8	1923	c.1754C>T	c.(1753-1755)tCg>tTg	p.S585L	GRM4_ENST00000455714.2_Missense_Mutation_p.S445L|GRM4_ENST00000535756.1_Missense_Mutation_p.S452L|GRM4_ENST00000544773.1_Missense_Mutation_p.S416L|GRM4_ENST00000545715.1_Missense_Mutation_p.S277L|GRM4_ENST00000374177.3_Missense_Mutation_p.S469L|GRM4_ENST00000538487.1_Missense_Mutation_p.S585L	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	585					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	GGCCCAGGGCGAGCCCCACTC	0.637000													12	20					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801863	185801863	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185801863A>C	ENST00000302277.6	+	4	2334	c.1740A>C	c.(1738-1740)atA>atC	p.I580I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	580						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						ACAACAAAATAAGGTTGAAAG	0.289000													24	65					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60359414	60359414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60359414G>A	ENST00000371204.3	-	9	1461	c.1418C>T	c.(1417-1419)cCc>cTc	p.P473L	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	473					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					ATTGTTTGGGGGCCTGAAGGT	0.463000													121	315					0	0	1	0	0
LGALS9	3965	broad.mit.edu	37	17	25967717	25967717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:25967717C>T	ENST00000395473.2	+	3	1719	c.251C>T	c.(250-252)cCc>cTc	p.P84L	LGALS9_ENST00000302228.5_Missense_Mutation_p.P84L|AC015688.3_ENST00000584605.1_3'UTR|LGALS9_ENST00000448970.2_3'UTR|LGALS9_ENST00000413914.2_Missense_Mutation_p.P27L|LGALS9_ENST00000313648.6_Missense_Mutation_p.P84L|LGALS9_ENST00000310394.5_Missense_Mutation_p.P84L	NM_009587.2	NP_033665.1	O00182	LEG9_HUMAN	lectin, galactoside-binding, soluble, 9	84	Beta-galactoside binding 1.|Galectin 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity			endometrium(3)|large_intestine(2)|lung(12)|skin(1)	18	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		AGCTGGGGGCCCGAGGAGAGG	0.547000													49	56					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37324718	37324718	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:37324718G>A	ENST00000373091.3	-	7	1111	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	GRIK3_ENST00000462621.1_5'UTR|GRIK3_ENST00000373093.4_Silent_p.F365F	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	365					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCTCCTTGATGAAGTTCATGA	0.617000													18	94					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7949293	7949293	+	Missense_Mutation	SNP	C	C	T	rs148940548	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7949293C>T	ENST00000309838.2	-	1	916	c.917G>A	c.(916-918)cGa>cAa	p.R306Q		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CACTCGCCTTCGCCATAATTT	0.373000													45	100					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145583669	145583669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145583669C>T	ENST00000532887.1	+	3	1100	c.517C>T	c.(517-519)Ccg>Tcg	p.P173S	SLC52A2_ENST00000540505.1_Missense_Mutation_p.P85S|SLC52A2_ENST00000329994.2_Missense_Mutation_p.P173S|SLC52A2_ENST00000402965.1_Missense_Mutation_p.P173S|SLC52A2_ENST00000527078.1_Missense_Mutation_p.P173S|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000530047.1_Missense_Mutation_p.P173S			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	173						integral to plasma membrane	receptor activity|riboflavin transporter activity										CCTCGAGTGCCCGCCAGCCCC	0.667000													21	100					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196636412	196636412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196636412G>A	ENST00000312428.6	-	61	11505	c.11405C>T	c.(11404-11406)tCg>tTg	p.S3802L	DNAH7_ENST00000409063.1_Missense_Mutation_p.S285L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3802					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATTTACGCACGAATCTCTTAT	0.358000													40	156					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148801858	148801858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148801858G>A	ENST00000378061.2	-	4	1237	c.1105C>T	c.(1105-1107)Cgg>Tgg	p.R369W		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	369					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GCAGCCTTCCGGGAGAAGCTC	0.577000													32	102					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26463032	26463032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26463032C>T	ENST00000265944.5	+	30	4005	c.3839C>T	c.(3838-3840)tCc>tTc	p.S1280F	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1280					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AATGAGACTTCCTTTAAAAAA	0.398000													16	40					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9560965	9560965	+	Silent	SNP	G	G	A	rs142086015		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9560965G>A	ENST00000378429.3	-	5	1363	c.817C>T	c.(817-819)Ctg>Ttg	p.L273L	PAK7_ENST00000378423.1_Silent_p.L273L|PAK7_ENST00000353224.5_Silent_p.L273L	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	273	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GTCTGATTCAGGTACGAAGAC	0.567000													35	90					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130511630	130511630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130511630G>A	ENST00000314830.8	-	5	1112	c.999C>T	c.(997-999)ggC>ggT	p.G333G	SH2D3C_ENST00000420366.1_Silent_p.G175G|SH2D3C_ENST00000373274.3_Silent_p.G173G|SH2D3C_ENST00000373276.3_Silent_p.G265G|SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Silent_p.G176G|SH2D3C_ENST00000429553.1_5'UTR	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	333					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCTGTCCCAGGCCATAGCTGG	0.647000													5	63					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347305	57347305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57347305G>A	ENST00000361249.3	+	5	748	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	218	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GTACCACTTTGAAGTAAGTCT	0.473000													36	85					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919003	21919003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21919003C>T	ENST00000240662.2	-	3	1274	c.929G>A	c.(928-930)cGa>cAa	p.R310Q	RP11-59N23.1_ENST00000542489.1_RNA	NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	310						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	GTAGGAGGTTCGTGCTTGTGT	0.483000													21	76					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43048468	43048468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43048468G>A	ENST00000316099.3	+	7	933	c.844G>A	c.(844-846)Gat>Aat	p.D282N	HNF4A_ENST00000415691.1_Missense_Mutation_p.D282N|HNF4A_ENST00000457232.1_Missense_Mutation_p.D260N|HNF4A_ENST00000443598.2_Missense_Mutation_p.D282N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	282					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCTGCAGATCGATGACAATGA	0.567000													28	84					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152786560	152786560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152786560C>T	ENST00000367255.5	-	18	2366	c.1765G>A	c.(1765-1767)Gaa>Aaa	p.E589K	SYNE1_ENST00000466159.2_Missense_Mutation_p.E589K|SYNE1_ENST00000413186.2_Missense_Mutation_p.E589K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E596K|SYNE1_ENST00000367253.4_Missense_Mutation_p.E589K|SYNE1_ENST00000367248.3_Missense_Mutation_p.E579K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E596K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E589K|SYNE1_ENST00000341594.5_Missense_Mutation_p.E596K|SYNE1_ENST00000495090.2_Missense_Mutation_p.E156K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	589					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCGGTGGTTTCATTCATGAAT	0.398000										HNSCC(10;0.0054)			19	19					0	0	1	0	0
C6orf58	352999	broad.mit.edu	37	6	127901570	127901570	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:127901570G>A	ENST00000329722.7	+	3	561	c.549G>A	c.(547-549)atG>atA	p.M183I		NM_001010905.1	NP_001010905.1	Q6P5S2	CF058_HUMAN	chromosome 6 open reading frame 58	183						extracellular region				kidney(3)|large_intestine(3)|liver(1)|lung(7)|pancreas(1)	15				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		CTGAGACAATGAACAAGTGGA	0.398000													32	62					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112194227	112194227	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:112194227G>A	ENST00000455480.2	+	22	3400	c.3223G>A	c.(3223-3225)Gag>Aag	p.E1075K	ACAD10_ENST00000313698.4_Missense_Mutation_p.E1044K|RP11-162P23.2_ENST00000546840.2_Intron	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	1044							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CGGCCCTGACGAGGTGCACCG	0.647000													4	11					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104896	183104896	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:183104896C>T	ENST00000435564.1	-	3	539	c.339G>A	c.(337-339)gaG>gaA	p.E113E	PDE1A_ENST00000536095.1_Silent_p.E9E|PDE1A_ENST00000409365.1_Silent_p.E97E|PDE1A_ENST00000456212.1_Silent_p.E113E|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Silent_p.E113E|PDE1A_ENST00000358139.2_Silent_p.E113E|PDE1A_ENST00000351439.5_Silent_p.E97E|PDE1A_ENST00000331935.6_Silent_p.E113E|PDE1A_ENST00000346717.4_Silent_p.E79E	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	113					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTGGTTTTTCCTCAGGTTTCT	0.418000													31	112					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222307703	222307703	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:222307703G>A	ENST00000281821.2	-	11	1961	c.1920C>T	c.(1918-1920)ctC>ctT	p.L640L	EPHA4_ENST00000409938.1_Silent_p.L640L|EPHA4_ENST00000409854.1_Silent_p.L640L|EPHA4_ENST00000392071.4_Silent_p.L589L	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	640	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CAGGCACTTTGAGACGCCCAC	0.443000													42	104					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87025895	87025895	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87025895C>T	ENST00000370563.3	+	3	344	c.300_splice	c.e3-1	p.A101_splice	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	101						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CATTCTCAGGCTGATGTTATA	0.353000													31	81					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82580119	82580119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82580119G>A	ENST00000423517.2	-	6	10122	c.9785C>T	c.(9784-9786)tCt>tTt	p.S3262F	PCLO_ENST00000333891.8_Missense_Mutation_p.S3262F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3193					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.S3262Y(2)|p.S3193Y(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGCTTCATAGACTGCAGCTC	0.478000													13	135					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89256788	89256788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89256788C>T	ENST00000289746.2	+	8	1181	c.1116C>T	c.(1114-1116)ccC>ccT	p.P372P		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	372	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CCAACGAGCCCCCCGTGTTCC	0.677000													5	20					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65678963	65678963	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65678963G>A	ENST00000352385.2	-	17	3086	c.2877C>T	c.(2875-2877)atC>atT	p.I959I		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	959						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						CACCCACGATGATGCCCGTGA	0.637000											OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	18					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120510351	120510351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120510351C>T	ENST00000397558.2	+	6	1126	c.1126C>T	c.(1126-1128)Cgc>Tgc	p.R376C	CCDC64_ENST00000446727.2_Intron|CCDC64_ENST00000257583.4_Missense_Mutation_p.R25C	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	376					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGCCAGGTTCGCTATCTGTG	0.522000													16	99					0	0	1	0	0
VEZT	55591	broad.mit.edu	37	12	95694267	95694267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95694267C>T	ENST00000436874.1	+	12	2263	c.2158C>T	c.(2158-2160)Ccc>Tcc	p.P720S	VEZT_ENST00000356859.4_3'UTR|VEZT_ENST00000261219.6_Missense_Mutation_p.P672S	NM_017599.3	NP_060069.3	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane protein	720						acrosomal vesicle|adherens junction|integral to membrane|nucleus				endometrium(2)|kidney(3)|large_intestine(1)|lung(14)|ovary(2)|upper_aerodigestive_tract(1)	23						CTCATTACAGCCCTCCATTAA	0.507000													13	38					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67555523	67555523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:67555523G>A	ENST00000335894.4	+	3	304	c.238G>A	c.(238-240)Gag>Aag	p.E80K	IQCH_ENST00000358767.3_5'UTR|IQCH_ENST00000512104.1_Missense_Mutation_p.E80K|IQCH_ENST00000546225.1_5'UTR	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	80										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		TGTTAATGATGAGAGCTTATA	0.323000													19	77					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12123311	12123311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:12123311C>T	ENST00000379388.2	+	4	3615	c.3283C>T	c.(3283-3285)Ctt>Ttt	p.L1095F		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1095					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CCATATTCACCTTGTTGCCAG	0.463000													10	50					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156742096	156742096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156742096C>T	ENST00000347377.6	+	13	1781	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F	CYFIP2_ENST00000377576.3_Silent_p.F450F|CYFIP2_ENST00000318218.6_Silent_p.F450F|CYFIP2_ENST00000541131.1_Silent_p.F375F|CYFIP2_ENST00000522463.1_Silent_p.F254F|CYFIP2_ENST00000521420.1_Silent_p.F424F|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Silent_p.F124F	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	450					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AATTTGCCTTCGTTGAGGTAG	0.527000													8	21					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70526220	70526220	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:70526220G>A	ENST00000327305.6	-	4	967	c.310C>T	c.(310-312)Cga>Tga	p.R104*	NETO1_ENST00000299430.2_Nonsense_Mutation_p.R103*|NETO1_ENST00000580049.1_5'UTR|NETO1_ENST00000583169.1_Nonsense_Mutation_p.R104*|NETO1_ENST00000397929.1_Nonsense_Mutation_p.R103*	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	104	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GGTCCATCTCGAACTTCAATA	0.378000													29	67					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802259	185802259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185802259G>A	ENST00000302277.6	+	4	2730	c.2136G>A	c.(2134-2136)ggG>ggA	p.G712G		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	712						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TACATTCTGGGAAACATAATT	0.308000													26	71					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743045	26743045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26743045C>T	ENST00000396005.3	-	1	526	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	SLC5A12_ENST00000280467.6_Missense_Mutation_p.E73K	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	73					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						CGGTAGACTTCAGAAGGGGTC	0.512000													23	59					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57719770	57719770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57719770G>A	ENST00000333493.4	+	11	1633	c.1472G>A	c.(1471-1473)gGg>gAg	p.G491E	GPR97_ENST00000327655.6_Missense_Mutation_p.G281E|RP11-405F3.4_ENST00000563062.1_RNA|GPR97_ENST00000450388.3_Missense_Mutation_p.G371E	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	491					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GTGACATGGGGGTTGGCCATC	0.612000													21	56					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71850804	71850804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71850804G>A	ENST00000445078.2	+	5	858	c.787G>A	c.(787-789)Gag>Aag	p.E263K	FOLR3_ENST00000456237.1_Missense_Mutation_p.E265K|FOLR3_ENST00000442948.2_Missense_Mutation_p.E222K			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	221					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	CAACCCCAATGAGGAGGTGGC	0.572000													18	42					0	0	1	0	0
ALKBH5	54890	broad.mit.edu	37	17	18087711	18087711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18087711C>T	ENST00000399138.4	+	1	159	c.154C>T	c.(154-156)Cct>Tct	p.P52S	RP11-258F1.1_ENST00000583062.1_RNA|ALKBH5_ENST00000541285.1_Intron|RP11-258F1.1_ENST00000577847.1_RNA	NM_017758.3	NP_060228.3	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5 (E. coli)	52						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|skin(1)	10	all_neural(463;0.228)					cgAACCTTACCCTGTGTCCGG	0.711000													3	4					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27802836	27802836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27802836C>T	ENST00000408964.2	+	1	3448	c.3397C>T	c.(3397-3399)Cat>Tat	p.H1133Y		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1133										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					ACTTAATTGCCATCATAAATT	0.493000													69	151					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88476368	88476368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88476368C>T	ENST00000394480.1	-	16	2085	c.1764G>A	c.(1762-1764)gaG>gaA	p.E588E	NTRK3_ENST00000542733.2_Silent_p.E490E|NTRK3_ENST00000355254.2_Silent_p.E588E|NTRK3_ENST00000357724.2_Silent_p.E580E|NTRK3_ENST00000558676.1_Silent_p.E580E|NTRK3_ENST00000360948.2_Silent_p.E588E|NTRK3_ENST00000557856.1_Silent_p.E580E	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	588	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCAGCTCGGCCTCCCTCTGGA	0.562000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			11	84					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105161027	105161027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:105161027C>T	ENST00000436393.2	+	23	3580	c.3339C>T	c.(3337-3339)atC>atT	p.I1113I	RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000507740.1_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	541					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGTAGCTATCGTTGGTCTGT	0.483000										HNSCC(12;0.0054)			25	56					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325254	158325254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158325254C>T	ENST00000444681.2	+	2	516	c.223C>T	c.(223-225)Cgc>Tgc	p.R75C	CD1E_ENST00000368157.1_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368165.3_Intron|CD1E_ENST00000368163.3_Missense_Mutation_p.R174C|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.R172C|CD1E_ENST00000368167.3_Missense_Mutation_p.R174C|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000368161.3_Missense_Mutation_p.R174C|CD1E_ENST00000368160.3_Missense_Mutation_p.R174C|CD1E_ENST00000368166.3_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	174					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					AGTGCTCAATCGCTACCTAGA	0.507000													31	67					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	88123744	88123744	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88123744G>A	ENST00000327946.7	-	2	274	c.189C>T	c.(187-189)tcC>tcT	p.S63S		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	63						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TGACCTTGATGGAGTAGGTGA	0.612000										Multiple Myeloma(13;0.14)			26	65					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870966	13870966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13870966C>T	ENST00000265104.4	-	24	3848	c.3744G>A	c.(3742-3744)aaG>aaA	p.K1248K	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1248	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CATCTAGGTCCTTAATTGGAC	0.373000									Kartagener syndrome				21	73					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142238075	142238075	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:142238075G>A	ENST00000389484.3	-	3	1204	c.233C>T	c.(232-234)cCc>cTc	p.P78L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	78	LDL-receptor class A 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTGATTCAAGGGGCACTTGAT	0.408000										TSP Lung(27;0.18)			14	107					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230572	21230572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21230572C>T	ENST00000233242.1	-	26	9295	c.9168G>A	c.(9166-9168)ttG>ttA	p.L3056L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3056					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACGAACTTTCAAATTCCCTT	0.393000													24	70					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12711243	12711243	+	Silent	SNP	C	C	T	rs140616597		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12711243C>T	ENST00000376221.1	+	2	270	c.270C>T	c.(268-270)acC>acT	p.T90T		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	90						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TTGTGGTGACCGACCTGCGTT	0.502000													44	107					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180053204	180053204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180053204C>T	ENST00000261937.6	-	9	1243	c.1165G>A	c.(1165-1167)Gtg>Atg	p.V389M	FLT4_ENST00000393347.3_Missense_Mutation_p.V389M|FLT4_ENST00000502649.1_Missense_Mutation_p.V389M|FLT4_ENST00000424276.2_5'UTR	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	389	Ig-like C2-type 4.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GCCTCTGTCACCTCCTTGAGC	0.627000													37	80					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104878	183104878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:183104878C>T	ENST00000435564.1	-	3	557	c.357G>A	c.(355-357)cgG>cgA	p.R119R	PDE1A_ENST00000536095.1_Silent_p.R15R|PDE1A_ENST00000409365.1_Silent_p.R103R|PDE1A_ENST00000456212.1_Silent_p.R119R|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Silent_p.R119R|PDE1A_ENST00000358139.2_Silent_p.R119R|PDE1A_ENST00000351439.5_Silent_p.R103R|PDE1A_ENST00000331935.6_Silent_p.R119R|PDE1A_ENST00000346717.4_Silent_p.R85R	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	119					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			GCACAATGCTCCGAAATTTTG	0.418000													31	113					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232651033	232651033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:232651033G>A	ENST00000366630.1	-	2	411	c.53C>T	c.(52-54)tCt>tTt	p.S18F	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.S18F			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	18					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GAACTTTGAAGAGGCTCTGCC	0.453000													8	66					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151128379	151128379	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151128379G>A	ENST00000370325.1	-	6	769	c.716C>T	c.(715-717)tCc>tTc	p.S239F	GABRE_ENST00000370328.3_Missense_Mutation_p.S239F|GABRE_ENST00000393914.3_Missense_Mutation_p.S46F			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	239					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GAGCTTCCAGGAGTTCTTCTC	0.433000													32	39					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190250839	190250839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190250839C>T	ENST00000367462.3	-	3	509	c.278G>A	c.(277-279)aGa>aAa	p.R93K	FAM5C_ENST00000534846.1_Intron|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000484105.1_Intron	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		93						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GAAATTTCTTCTCTCAACTGC	0.398000													20	91					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925570	54925570	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54925570C>T	ENST00000293373.6	+	25	2821	c.2742C>T	c.(2740-2742)atC>atT	p.I914I	NCKAP1L_ENST00000545638.2_Silent_p.I864I	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	914					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TTGGGGTTATCCTCAGTTTCA	0.493000													20	48					0	0	1	0	0
AGK	55750	broad.mit.edu	37	7	141336797	141336797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141336797C>T	ENST00000355413.4	+	11	966	c.706C>T	c.(706-708)Cac>Tac	p.H236Y	AGK_ENST00000473247.1_Missense_Mutation_p.H208Y|AGK_ENST00000535825.1_Missense_Mutation_p.H233Y	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase	236					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					CAAAGCAGCCCACTTTTTCAG	0.313000													10	50					0	0	1	0	0
TRAV12-2	28673	broad.mit.edu	37	14	22356412	22356412	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22356412G>A	ENST00000390437.2	+	0	175																											CCAACAGAAGGAGGTGGAGCA	0.498000													18	58					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100334587	100334587	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100334587C>T	ENST00000542585.1	+	0	557				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCTGCTGCTGCTCTCGGGTGA	0.652000													4	10					0	0	1	0	0
CETN1	1068	broad.mit.edu	37	18	580894	580894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:580894C>T	ENST00000327228.3	+	1	528	c.486C>T	c.(484-486)ttC>ttT	p.F162F		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	162	EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						AGGAGGAGTTCCTTCGGATCA	0.532000													20	45					0	0	1	0	0
PPP1R17	10842	broad.mit.edu	37	7	31735138	31735138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31735138G>A	ENST00000342032.3	+	3	766	c.138G>A	c.(136-138)aaG>aaA	p.K46K	PPP1R17_ENST00000409146.3_Intron	NM_006658.4	NP_006649.2	O96001	GSUB_HUMAN	protein phosphatase 1, regulatory subunit 17	46					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction											AGCCTAGAAAGGGAAAAAATG	0.388000													31	98					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128335798	128335798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128335798G>A	ENST00000389524.4	+	9	993	c.940G>A	c.(940-942)Gag>Aag	p.E314K	MYO7B_ENST00000428314.1_Missense_Mutation_p.E314K|MYO7B_ENST00000409816.2_Missense_Mutation_p.E314K			Q6PIF6	MYO7B_HUMAN	myosin VIIB	314	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTCCGACTCCGAGAGCTGGGA	0.607000													10	32					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200943915	200943915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200943915C>T	ENST00000332129.2	-	33	5018	c.4702G>A	c.(4702-4704)Ggt>Agt	p.G1568S	KIF21B_ENST00000360529.5_Missense_Mutation_p.G1568S|KIF21B_ENST00000461742.2_Missense_Mutation_p.G1581S|KIF21B_ENST00000422435.2_Missense_Mutation_p.G1581S	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1581					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TTGATCTCACCGATGGGTGTG	0.612000													42	82					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5731072	5731072	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:5731072C>T	ENST00000382674.2	+	3	523	c.339C>T	c.(337-339)ttC>ttT	p.F113F	EVC_ENST00000264956.6_Silent_p.F113F|EVC_ENST00000509451.1_Silent_p.F113F			P57679	EVC_HUMAN	Ellis van Creveld syndrome	113					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				TCACAGCATTCGCCCTGAAGG	0.483000													7	85					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14823176	14823176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14823176C>T	ENST00000380881.4	-	14	3137	c.2322G>A	c.(2320-2322)gtG>gtA	p.V774V	FREM1_ENST00000380880.3_Silent_p.V773V|FREM1_ENST00000422223.2_Silent_p.V773V			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	773					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CTTGATTGTCCACTGGGAGGA	0.413000													7	56					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27802502	27802502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27802502G>A	ENST00000408964.2	+	1	3114	c.3063G>A	c.(3061-3063)ggG>ggA	p.G1021G		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1021										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CATGTGCAGGGGGCCAGCTTC	0.438000													16	92					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19822367	19822367	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19822367G>A	ENST00000344099.3	-	4	1861	c.1723C>T	c.(1723-1725)Cga>Tga	p.R575*		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R575*(1)		breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				TCATGCATTCGAAATTTACTG	0.403000													24	64					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104071293	104071293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104071293G>A	ENST00000388887.2	+	25	2913	c.2709G>A	c.(2707-2709)ggG>ggA	p.G903G		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	903	EGF-like 8.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTTGGACAGGGAATGGGAGAG	0.572000													30	103					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018324	1018324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1018324C>T	ENST00000398484.2	+	7	1524	c.944C>T	c.(943-945)cCc>cTc	p.P315L	FGFRL1_ENST00000264748.6_Missense_Mutation_p.P315L|FGFRL1_ENST00000510644.1_Missense_Mutation_p.P315L|FGFRL1_ENST00000504138.1_Missense_Mutation_p.P315L			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	315	Ig-like C2-type 3.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TGGTCGCGGCCCGACGGCTCC	0.647000													18	74					0	0	1	0	0
TEX33	339669	broad.mit.edu	37	22	37397962	37397962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37397962C>T	ENST00000405091.2	-	4	656	c.405G>A	c.(403-405)acG>acA	p.T135T	TEX33_ENST00000402860.3_Silent_p.T50T|TEX33_ENST00000381821.1_Silent_p.T135T			O43247	EAN57_HUMAN	testis expressed 33	135																	CCTTCTGGTTCGTGGGCGTGC	0.622000													4	25					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94502778	94502778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94502778G>A	ENST00000370225.3	-	25	3822	c.3736C>T	c.(3736-3738)Ctt>Ttt	p.L1246F		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1246					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTCTGAAAAGGCTGGCATAT	0.483000													16	110					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15376433	15376433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15376433G>A	ENST00000263377.2	-	5	802	c.581C>T	c.(580-582)tCc>tTc	p.S194F	BRD4_ENST00000360016.5_Missense_Mutation_p.S194F|BRD4_ENST00000371835.4_Missense_Mutation_p.S194F	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	194					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TGGTACCGTGGAAACGCCAGG	0.567000			T	C15orf55	lethal midline carcinoma of young people								69	178					0	0	1	0	0
CALHM1	255022	broad.mit.edu	37	10	105215432	105215432	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105215432T>A	ENST00000329905.5	-	2	764	c.628A>T	c.(628-630)Acg>Tcg	p.T210S	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	210						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						GCGGCCTGCGTGAAGCAGGGC	0.612000													9	62					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7262416	7262416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7262416G>A	ENST00000361972.4	-	11	1377	c.1287C>T	c.(1285-1287)tcC>tcT	p.S429S	SFMBT2_ENST00000397167.1_Silent_p.S429S	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	429					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						CACTCACAACGGAGGCCACAC	0.517000													101	216					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43858479	43858479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43858479G>A	ENST00000389420.3	-	10	1423	c.1424C>T	c.(1423-1425)cCt>cTt	p.P475L	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.P475L	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	475	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAGTTCTGAAGGCAGATTATA	0.383000													11	70					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48371472	48371472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48371472G>A	ENST00000395702.2	+	2	1167	c.940G>A	c.(940-942)Gaa>Aaa	p.E314K	ZNF488_ENST00000494156.1_3'UTR|ZNF488_ENST00000586537.1_Missense_Mutation_p.E207K			Q96MN9	ZN488_HUMAN	zinc finger protein 488	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						GAAGCGGAGAGAAGAGGCCCT	0.597000													38	91					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62859106	62859106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62859106G>A	ENST00000584306.1	-	10	3614	c.3084C>T	c.(3082-3084)ctC>ctT	p.L1028L	LRRC37A3_ENST00000339474.5_Silent_p.L146L|LRRC37A3_ENST00000334962.5_Silent_p.L5L|LRRC37A3_ENST00000319651.5_Silent_p.L1028L|LRRC37A3_ENST00000400877.3_Silent_p.L66L	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1028						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TAAATTGGCAGAGGCAGCAGG	0.453000													96	217					0	0	1	0	0
CTAGE6	340307	broad.mit.edu	37	7	143453470	143453470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143453470C>T	ENST00000470691.2	-	1	1319	c.1282G>A	c.(1282-1284)Gaa>Aaa	p.E428K		NM_178561.4	NP_848656.2			CTAGE family, member 6													Melanoma(164;0.0903)					TCCAGCTGTTCAGTGGCACGG	0.383000													41	325					0	0	1	0	0
CCRL2	9034	broad.mit.edu	37	3	46450311	46450311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46450311C>T	ENST00000399036.3	+	2	1093	c.741C>T	c.(739-741)ttC>ttT	p.F247F	ACKR5_ENST00000400882.2_Silent_p.F247F|ACKR5_ENST00000357392.4_Silent_p.F259F|ACKR5_ENST00000400880.3_Silent_p.F247F	NM_003965.4	NP_003956.2																					TGGTAGTCTTCCTTCTGATGT	0.403000													144	384					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	87917351	87917351	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87917351G>A	ENST00000518476.1	+	3	252	c.201G>A	c.(199-201)atG>atA	p.M67I		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	67										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						ATACATTTATGAAGCAATATC	0.358000													8	24					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614802	247614802	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247614802G>A	ENST00000318749.6	-	1	506	c.483C>T	c.(481-483)ttC>ttT	p.F161F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCACCTGCACGAAGGAGTTGC	0.602000													9	40					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55874926	55874926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55874926G>A	ENST00000388975.3	-	8	959	c.843C>T	c.(841-843)ttC>ttT	p.F281F		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	281					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GGAGCTTAACGAAGTCACAGT	0.328000													26	56					0	0	1	0	0
TMEM9	252839	broad.mit.edu	37	1	201115880	201115880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201115880G>A	ENST00000367330.1	-	3	771	c.255C>T	c.(253-255)acC>acT	p.T85T	TMEM9_ENST00000367333.1_Silent_p.T88T|TMEM9_ENST00000367334.5_Silent_p.T85T|TMEM9_ENST00000367329.1_Silent_p.T85T|TMEM9_ENST00000367332.1_Silent_p.T88T			Q9P0T7	TMEM9_HUMAN	transmembrane protein 9	85					transport	integral to membrane|late endosome membrane|lysosomal membrane				liver(1)|lung(1)|stomach(1)	3		Breast(1374;0.000301)				TGATGGTGGTGGTGCTGCGCT	0.592000													19	99					0	0	1	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273370	26273370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26273370C>T	ENST00000377733.2	+	1	227	c.167C>T	c.(166-168)tCg>tTg	p.S56L		NM_003525.2	NP_003516.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	56					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			central_nervous_system(1)|cervix(2)|endometrium(3)|large_intestine(1)|lung(8)|urinary_tract(1)	16						ACCGGCATCTCGTCCAAGGCT	0.567000													104	261					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10261405	10261405	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10261405C>T	ENST00000256458.4	+	8	1035	c.945C>T	c.(943-945)atC>atT	p.I315I		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	315	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						GTGTCAGCATCTGCTCAGGGC	0.567000													17	30					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29821054	29821054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:29821054C>T	ENST00000375398.2	-	11	2335	c.1886G>A	c.(1885-1887)gGt>gAt	p.G629D	SVIL_ENST00000355867.4_Missense_Mutation_p.G629D|SVIL_ENST00000375400.3_Intron			O95425	SVIL_HUMAN	supervillin	629					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CCGTTCCACACCGGTGGGCAA	0.488000													33	79					0	0	1	0	0
C10orf113	387638	broad.mit.edu	37	10	21414770	21414770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21414770C>T	ENST00000534331.1	-	2	500	c.450G>A	c.(448-450)ctG>ctA	p.L150L	NEBL_ENST00000417816.2_Intron|C10orf113_ENST00000529198.1_3'UTR|C10orf113_ENST00000377118.4_Silent_p.L140L	NM_001010896.2	NP_001010896.2	Q5VZT2	CJ113_HUMAN	chromosome 10 open reading frame 113	150										endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|pancreas(1)	7						AAGTCATTTTCAGCACCTTCT	0.393000													51	163					0	0	1	0	0
RBM6	10180	broad.mit.edu	37	3	50099460	50099460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50099460C>T	ENST00000443081.1	+	15	3028	c.2109C>T	c.(2107-2109)ccC>ccT	p.P703P	RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000539992.1_Silent_p.P177P|RBM6_ENST00000266022.4_Silent_p.P835P|RBM6_ENST00000422955.1_Silent_p.P313P|RBM6_ENST00000442092.1_Silent_p.P313P			P78332	RBM6_HUMAN	RNA binding motif protein 6	835					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AAAAAAAACCCACCAGTCAAG	0.418000													19	63					0	0	1	0	0
VNN3	55350	broad.mit.edu	37	6	133047941	133047941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:133047941G>A	ENST00000367927.5	-	4	820	c.748C>T	c.(748-750)Cct>Tct	p.P250S	VNN3_ENST00000423615.2_Intron|VNN3_ENST00000414302.2_3'UTR|VNN3_ENST00000427187.2_Intron|VNN3_ENST00000519686.2_3'UTR|VNN3_ENST00000509351.1_Intron|VNN3_ENST00000425515.2_3'UTR|VNN3_ENST00000392393.3_3'UTR|VNN3_ENST00000417437.2_Intron|VNN3_ENST00000275223.3_Intron|VNN3_ENST00000207771.3_Missense_Mutation_p.P249L|VNN3_ENST00000450865.2_Silent_p.S128S					vanin 3											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	8	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00242)|GBM - Glioblastoma multiforme(226;0.0168)		TGAATGGAAGGGAACAGCCGA	0.542000													31	50					0	0	1	0	0
SPRED1	161742	broad.mit.edu	37	15	38591722	38591722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:38591722C>T	ENST00000299084.4	+	2	1041	c.181C>T	c.(181-183)Cgt>Tgt	p.R61C	SPRED1_ENST00000561205.1_3'UTR	NM_152594.2	NP_689807.1	Q7Z699	SPRE1_HUMAN	sprouty-related, EVH1 domain containing 1	61	WH1.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			kidney(6)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CTTTTTTATCCGTGGAGAGCG	0.383000									Legius syndrome				25	65					0	0	1	0	0
TCP10L	140290	broad.mit.edu	37	21	33956525	33956525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:33956525C>T	ENST00000300258.3	-	2	203	c.90G>A	c.(88-90)aaG>aaA	p.K30K		NM_144659.5	NP_653260.1			t-complex 10-like											breast(1)|central_nervous_system(1)|liver(1)|skin(1)	4						CCACAGCTGTCTTCTCCATGA	0.632000													29	65					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158291210	158291210	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158291210C>T	ENST00000264192.3	-	2	345	c.224_splice	c.e2+1	p.R75_splice	CYTIP_ENST00000540637.1_5'UTR|CYTIP_ENST00000497432.1_5'UTR	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	75					regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						ATCTCTTTACCTTTGAGACCA	0.378000													8	28					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188077	7188077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7188077C>T	ENST00000542285.1	-	11	1870	c.1721G>A	c.(1720-1722)gGa>gAa	p.G574E				P00736	C1R_HUMAN	complement component 1, r subcomponent	626	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCTATTCTTTCCCCGGAGCCA	0.542000													12	26					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63726872	63726872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:63726872G>A	ENST00000421025.1	+	5	1130	c.861G>A	c.(859-861)aaG>aaA	p.K287K	ZNF679_ENST00000255746.4_Silent_p.K287K	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						CTAACCACAAGAGAATTCATA	0.428000													24	52					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146805352	146805352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:146805352G>A	ENST00000361727.3	+	5	1180	c.664G>A	c.(664-666)Gaa>Aaa	p.E222K		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	222	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.E222Q(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTCTGAAAGTGAAGGAGTAAT	0.398000										HNSCC(39;0.1)			23	34					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200880878	200880878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200880878C>T	ENST00000367342.4	+	9	1712	c.1512C>T	c.(1510-1512)gtC>gtT	p.V504V	C1orf106_ENST00000413687.2_Silent_p.V419V	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	504										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						GAGAGCTGGTCGCCCACCACC	0.701000													41	45					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48607739	48607739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48607739G>A	ENST00000328333.8	-	97	7516	c.7409C>T	c.(7408-7410)cCc>cTc	p.P2470L	COL7A1_ENST00000454817.1_Missense_Mutation_p.P2438L	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2470	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCGCCTCGGGGCCCAGGCAG	0.622000													23	72					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31318615	31318615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31318615C>T	ENST00000269197.5	+	11	1247	c.1247C>T	c.(1246-1248)cCt>cTt	p.P416L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TCTCCAGAGCCTGGTTTCTGT	0.453000													17	38					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919144	12919144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12919144C>T	ENST00000240189.2	+	2	367	c.280C>T	c.(280-282)Cgc>Tgc	p.R94C		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	94										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACAGAAGGATCGCCCCAGGTG	0.552000													95	308					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432527	30432527	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30432527G>A	ENST00000375978.3	-	1	893	c.819C>T	c.(817-819)gcC>gcT	p.A273A		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	273					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CAGGGGAGGGGGCTGCTGAGG	0.652000													9	16					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190194	209190194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:209190194C>T	ENST00000264380.4	+	20	2817	c.2659C>T	c.(2659-2661)Cct>Tct	p.P887S		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	887					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						AATGCAAAACCCTTCATTCCA	0.468000													34	90					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1278759	1278759	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1278759G>A	ENST00000310581.5	-	6	2340	c.2283C>T	c.(2281-2283)agC>agT	p.S761S	TERT_ENST00000296820.5_Silent_p.S761S|TERT_ENST00000508104.2_Silent_p.S761S|TERT_ENST00000334602.6_Silent_p.S761S	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	761	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACCTTACGTGGCTCTTGAAGG	0.552000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				152	308					0	0	1	0	0
C16orf46	123775	broad.mit.edu	37	16	81095106	81095106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81095106G>A	ENST00000378611.4	-	3	963	c.848C>T	c.(847-849)tCc>tTc	p.S283F	C16orf46_ENST00000299578.5_Missense_Mutation_p.S283F|RP11-303E16.8_ENST00000564536.1_RNA	NM_001100873.1	NP_001094343.1	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46	283										NS(1)|endometrium(2)|large_intestine(3)|lung(9)|prostate(1)|stomach(1)|urinary_tract(1)	18						GGCCGCTGGGGAAGGGGAGGA	0.577000													44	186					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148258	34148258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34148258G>A	ENST00000346193.3	-	1	2189	c.2138C>T	c.(2137-2139)cCt>cTt	p.P713L		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	713										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GTCAATCAAAGGTTCATCACT	0.423000													53	37					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55578978	55578978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55578978C>T	ENST00000333973.2	+	1	125	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TGGCTGAGTTCATTCTCCTTG	0.423000													71	196					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673597	186673597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:186673597G>A	ENST00000343098.5	+	17	19831	c.19831G>A	c.(19831-19833)Gtt>Att	p.V6611I	FSIP2_ENST00000424728.1_Missense_Mutation_p.V6522I	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AATTAAAATAGTTCCACATGT	0.303000													10	67					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107677897	107677897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107677897C>T	ENST00000388781.3	-	30	4698	c.4615G>A	c.(4615-4617)Gaa>Aaa	p.E1539K	LAMB4_ENST00000205386.4_Missense_Mutation_p.E1539K|LAMB4_ENST00000483484.1_5'UTR|LAMB4_ENST00000388780.3_Missense_Mutation_p.E1539K	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1539	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						AACCTGTTTTCATCTGTCCTG	0.388000													77	252					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155127867	155127867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:155127867C>T	ENST00000286448.6	+	4	461	c.296C>T	c.(295-297)cCa>cTa	p.P99L	VAMP7_ENST00000262640.6_Missense_Mutation_p.P99L|VAMP7_ENST00000460621.1_Missense_Mutation_p.P58L|VAMP7_ENST00000479687.1_3'UTR	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	99	Longin.				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACAGCACTTCCATATGCCATG	0.393000													58	116					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48624743	48624743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48624743G>A	ENST00000328333.8	-	23	3126	c.3019C>T	c.(3019-3021)Cca>Tca	p.P1007S	COL7A1_ENST00000454817.1_Missense_Mutation_p.P1007S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1007	Fibronectin type-III 9.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GAGATCCCTGGAAGTGTCTGC	0.597000													5	6					0	0	1	0	0
PTGFR	5737	broad.mit.edu	37	1	78958579	78958579	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:78958579C>T	ENST00000370756.3	+	2	388	c.151C>T	c.(151-153)Ctc>Ttc	p.L51F	PTGFR_ENST00000370758.1_Missense_Mutation_p.L51F|PTGFR_ENST00000370757.3_Missense_Mutation_p.L51F	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	51					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CATCGCCATTCTCATGAAGGC	0.443000													58	108					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185798354	185798354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185798354G>A	ENST00000302277.6	+	3	874	c.280G>A	c.(280-282)Gaa>Aaa	p.E94K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	94						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GAAACAAAGGGAATTTGCTCG	0.358000													24	66					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31697609	31697609	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:31697609C>T	ENST00000357033.4	-	53	7961	c.7755G>A	c.(7753-7755)tgG>tgA	p.W2585*	DMD_ENST00000378707.3_Nonsense_Mutation_p.W125*|DMD_ENST00000378677.2_Nonsense_Mutation_p.W2581*|DMD_ENST00000359836.1_Nonsense_Mutation_p.W125*|DMD_ENST00000541735.1_Nonsense_Mutation_p.W125*|DMD_ENST00000474231.1_Nonsense_Mutation_p.W125*|DMD_ENST00000343523.2_Nonsense_Mutation_p.W125*	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2585					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TAGCTTCCAGCCATTGTGTTG	0.443000													20	16					0	0	1	0	0
CRTC1	23373	broad.mit.edu	37	19	18856637	18856637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18856637C>T	ENST00000338797.6	+	4	321	c.296C>T	c.(295-297)cCc>cTc	p.P99L	CRTC1_ENST00000601916.1_Missense_Mutation_p.P8L|CRTC1_ENST00000321949.8_Missense_Mutation_p.P83L|CRTC1_ENST00000594658.1_Missense_Mutation_p.P42L	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	83					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						CCCCAGACCCCCTTCCAATCC	0.662000													34	149					0	0	1	0	0
SF3B3	23450	broad.mit.edu	37	16	70605012	70605012	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70605012C>T	ENST00000302516.5	+	25	3634	c.3423C>T	c.(3421-3423)ttC>ttT	p.F1141F		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	1141					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				ATGACTTCTTCCAGCATGTGG	0.498000													51	136					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2622120	2622120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2622120G>A	ENST00000399655.1	+	9	1625	c.1360G>A	c.(1360-1362)Gaa>Aaa	p.E454K	CACNA1C_ENST00000347598.4_Missense_Mutation_p.E454K|CACNA1C_ENST00000399591.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000480911.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000344100.3_Missense_Mutation_p.E454K|CACNA1C_ENST00000399597.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000335762.5_Missense_Mutation_p.E454K|CACNA1C_ENST00000399595.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399603.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399617.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399606.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399621.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399601.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399638.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399649.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399644.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399629.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000327702.7_Missense_Mutation_p.E454K|CACNA1C_ENST00000399634.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399637.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000406454.3_Missense_Mutation_p.E454K|CACNA1C_ENST00000402845.3_Missense_Mutation_p.E454K|CACNA1C_ENST00000399641.1_Missense_Mutation_p.E454K	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	454					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GAATGAGGACGAAGGCATGGA	0.552000													5	7					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110819735	110819735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110819735G>A	ENST00000282356.4	+	11	1391	c.993G>A	c.(991-993)aaG>aaA	p.K331K	CAMK4_ENST00000512453.1_Silent_p.K331K|CAMK4_ENST00000512890.1_3'UTR	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	331	Calmodulin-binding (Potential).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		CAGCGGTGAAGGCTGTGGTGG	0.557000													15	35					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141128297	141128297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141128297C>T	ENST00000389484.3	-	71	11961	c.10990G>A	c.(10990-10992)Gaa>Aaa	p.E3664K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3664	LDL-receptor class A 29.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTTCTCTTCATCACTGCCA	0.393000										TSP Lung(27;0.18)			111	229					0	0	1	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21929377	21929377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21929377C>T	ENST00000542643.2	-	21	1838	c.1536G>A	c.(1534-1536)acG>acA	p.T512T	RAP1GAP_ENST00000374763.2_Silent_p.T571T|RAP1GAP_ENST00000374765.4_Silent_p.T486T|RAP1GAP_ENST00000374761.2_Silent_p.T517T|RAP1GAP_ENST00000290101.4_Silent_p.T550T	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	487					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		ACTTCTTCCTCGTGGGGCTCT	0.647000													4	47					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125281491	125281491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125281491G>A	ENST00000340750.1	+	1	72	c.72G>A	c.(70-72)caG>caA	p.Q24Q		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Q24H(1)		large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						CAGAGCAGCAGGCTGTGTTCT	0.557000													28	128					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	19062482	19062482	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19062482C>T	ENST00000375375.3	+	8	2110	c.1512C>T	c.(1510-1512)tcC>tcT	p.S504S	PAX7_ENST00000420770.2_Intron|PAX7_ENST00000400661.3_Silent_p.S502S	NM_002584.2|NM_013945.2	NP_002575.1|NP_039236.1	P23759	PAX7_HUMAN	paired box 7	504					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		ggggaatgtccatttcacaga	0.542000			T	FOXO1A	alveolar rhabdomyosarcoma								11	12					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123901226	123901226	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123901226G>A	ENST00000431524.1	+	1	930	c.897G>A	c.(895-897)ttG>ttA	p.L299L		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AAGCTCTGTTGAAGCTGAAAG	0.458000													30	81					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149882467	149882467	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149882467C>T	ENST00000369146.3	-	4	1356	c.866G>A	c.(865-867)cGa>cAa	p.R289Q	SV2A_ENST00000369145.1_Missense_Mutation_p.R289Q	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	289					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ATGCTCCCCTCGTTTCTCCTG	0.527000													8	44					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118357408	118357408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118357408G>A	ENST00000528052.1	+	7	714	c.643G>A	c.(643-645)Gac>Aac	p.D215N	PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.D215N|PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.D215N			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	215					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		CTCTGATGCTGACTTTGTTGA	0.478000													32	68					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14478466	14478466	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14478466C>T	ENST00000581457.1	-	0	1442					NR_024076.1																						TCGTATTTTTCTTCTCTGCGC	0.438000													6	7					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166976277	166976277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:166976277G>A	ENST00000061240.2	+	13	2221	c.1574G>A	c.(1573-1575)gGa>gAa	p.G525E	TLL1_ENST00000507499.1_Missense_Mutation_p.G548E	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	525	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GTTAGAGATGGAACCAGTGAA	0.338000													30	83					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74695422	74695422	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74695422G>A	ENST00000373032.3	-	4	633	c.541C>T	c.(541-543)Cag>Tag	p.Q181*		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	181					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					GCTGCCCGCTGACTATTCATA	0.507000													34	70					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	628806	628806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:628806C>T	ENST00000321878.5	+	6	1250	c.1091C>T	c.(1090-1092)cCc>cTc	p.P364L	PIGQ_ENST00000544860.1_3'UTR|PIGQ_ENST00000409527.2_Missense_Mutation_p.P364L|PIGQ_ENST00000026218.5_Missense_Mutation_p.P364L	NM_004204.3	NP_004195.2	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	364	Leu-rich.				C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				CTCATGTCCCCCTTCGTGGAG	0.657000													44	66					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241727533	241727533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241727533C>T	ENST00000498729.2	-	4	544	c.298G>A	c.(298-300)Ggt>Agt	p.G100S	KIF1A_ENST00000320389.7_Missense_Mutation_p.G100S	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	100	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TTGCCGGCACCCGTCTGCCCA	0.642000													4	10					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678521	88678521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88678521C>T	ENST00000394480.1	-	10	1336	c.1015G>A	c.(1015-1017)Ggg>Agg	p.G339R	NTRK3_ENST00000542733.2_Missense_Mutation_p.G241R|NTRK3_ENST00000355254.2_Missense_Mutation_p.G339R|NTRK3_ENST00000317501.3_Missense_Mutation_p.G339R|NTRK3_ENST00000357724.2_Missense_Mutation_p.G339R|NTRK3_ENST00000540489.2_Missense_Mutation_p.G339R|NTRK3_ENST00000558676.1_Missense_Mutation_p.G339R|NTRK3_ENST00000360948.2_Missense_Mutation_p.G339R|NTRK3_ENST00000557856.1_Missense_Mutation_p.G339R	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	339	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGAGGCTGCCCATTGTGCAGC	0.592000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			16	107					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	861007	861007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:861007G>A	ENST00000316157.3	-	15	1739	c.1699C>T	c.(1699-1701)Ctc>Ttc	p.L567F	LARP4B_ENST00000469487.1_5'UTR	NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	567							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						TCTGCACTGAGGGTCTGAAAC	0.592000													17	39					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594815	64594815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64594815G>A	ENST00000342711.5	-	33	4205	c.4206C>T	c.(4204-4206)ttC>ttT	p.F1402F		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1402					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						TCTTGGTGCGGAACAGCTGGC	0.652000													27	121					0	0	1	0	0
ZFP1	162239	broad.mit.edu	37	16	75203605	75203605	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:75203605C>T	ENST00000393430.2	+	4	721	c.597C>T	c.(595-597)ctC>ctT	p.L199L	ZFP1_ENST00000568079.1_3'UTR|ZFP1_ENST00000332307.4_Silent_p.L166L|ZFP1_ENST00000570010.1_Silent_p.L199L|ZFP1_ENST00000464850.1_3'UTR			Q6P2D0	ZFP1_HUMAN	ZFP1 zinc finger protein	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	12						AGTCACTCCTCATTAGTCATA	0.358000													13	44					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19451867	19451867	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19451867C>T	ENST00000396229.2	+	3	1256	c.507C>T	c.(505-507)aaC>aaT	p.N169N	TMC5_ENST00000542583.2_Silent_p.N169N|TMC5_ENST00000541464.1_Silent_p.N169N|TMC5_ENST00000381414.4_Silent_p.N169N	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	169						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CTCAGAGCAACTCTGATCATC	0.478000													43	144					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78474955	78474955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78474955C>T	ENST00000258873.4	-	7	952	c.747G>A	c.(745-747)atG>atA	p.M249I	ACSBG1_ENST00000560817.1_Missense_Mutation_p.M7I|ACSBG1_ENST00000541759.1_Missense_Mutation_p.M7I	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	249					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						TGAATTCCTCCATCTGTAGCC	0.607000													23	86					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39884771	39884771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39884771G>A	ENST00000260356.5	+	17	2700	c.2535G>A	c.(2533-2535)ctG>ctA	p.L845L		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	845					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TCTTTCAGCTGGACTCTGACT	0.433000													5	13					0	0	1	0	0
TOP2B	7155	broad.mit.edu	37	3	25665215	25665215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:25665215G>A	ENST00000435706.2	-	21	2704	c.2503C>T	c.(2503-2505)Cct>Tct	p.P835S	TOP2B_ENST00000264331.4_Missense_Mutation_p.P840S			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa	840					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						TCCACAGCAGGAAAAAGTAGC	0.333000													9	25					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180338372	180338372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180338372G>A	ENST00000231229.4	+	3	665	c.431G>A	c.(430-432)gGa>gAa	p.G144E	BTNL8_ENST00000505126.1_5'UTR|BTNL8_ENST00000508408.1_Missense_Mutation_p.G144E|BTNL8_ENST00000511704.1_Missense_Mutation_p.G28E|BTNL8_ENST00000533815.2_5'UTR|BTNL8_ENST00000400707.3_Missense_Mutation_p.G19E|BTNL8_ENST00000340184.4_Missense_Mutation_p.G144E	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	144	Ig-like V-type 2.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCATCACGGGATATGTTGAT	0.522000													38	399					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64159417	64159417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:64159417G>A	ENST00000395254.3	+	5	1373	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K	ZNF365_ENST00000466727.1_3'UTR|ZNF365_ENST00000395255.3_Intron|ZNF365_ENST00000410046.3_Intron	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					GGCCATTCACGAACAGGCTGA	0.547000													22	180					0	0	1	0	0
SMCP	4184	broad.mit.edu	37	1	152856947	152856947	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152856947C>T	ENST00000368765.3	+	2	199	c.49C>T	c.(49-51)Caa>Taa	p.Q17*		NM_030663.2	NP_109588.2	P49901	MCSP_HUMAN	sperm mitochondria-associated cysteine-rich protein	17	7 X 7 (OR 8) AA approximate repeats.				penetration of zona pellucida|sperm motility	mitochondrial membrane				breast(1)|cervix(1)|endometrium(1)|lung(4)|urinary_tract(1)	8	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAAAGGCAATCAATGCTGCCC	0.458000													16	95					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43322721	43322721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43322721G>A	ENST00000331495.3	+	22	3166	c.2830G>A	c.(2830-2832)Gag>Aag	p.E944K	FMNL1_ENST00000587489.1_Missense_Mutation_p.E522K|CTD-2020K17.4_ENST00000420431.2_RNA|FMNL1_ENST00000328118.3_Missense_Mutation_p.E944K	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	944	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						GGTGCTCAAGGAGTTCCTGAG	0.632000													34	39					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112524985	112524985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112524985C>T	ENST00000369697.1	-	1	433	c.364G>A	c.(364-366)Ggc>Agc	p.G122S	KCND3_ENST00000315987.2_Missense_Mutation_p.G122S|KCND3_ENST00000302127.4_Missense_Mutation_p.G122S			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	122						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGGAGGATGCCGTAGAAGGCC	0.617000													10	71					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	136111119	136111119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136111119G>A	ENST00000401392.1	-	4	472	c.260C>T	c.(259-261)cCt>cTt	p.P87L	ZRANB3_ENST00000264159.6_Missense_Mutation_p.P87L|ZRANB3_ENST00000536680.1_Missense_Mutation_p.P87L			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	87	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		CAGAGACGAAGGGACCACTAT	0.358000													17	36					0	0	1	0	0
SLC39A1	27173	broad.mit.edu	37	1	153932929	153932929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153932929G>A	ENST00000368623.3	-	3	1379	c.620C>T	c.(619-621)gCc>gTc	p.A207V	SLC39A1_ENST00000310483.6_Missense_Mutation_p.A207V|SLC39A1_ENST00000537590.1_Missense_Mutation_p.A105V|SLC39A1_ENST00000356205.4_Missense_Mutation_p.A207V|SLC39A1_ENST00000368621.1_Missense_Mutation_p.A207V			Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter), member 1	207						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		CAGCTCCATGGCCCGAGCCCG	0.662000													15	34					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40554830	40554830	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:40554830G>A	ENST00000297737.6	-	4	429	c.283C>T	c.(283-285)Caa>Taa	p.Q95*	ZMAT4_ENST00000315769.7_Nonsense_Mutation_p.Q95*	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	95						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			ATTTTGCCTTGATAATGGGAA	0.517000													43	123					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212798854	212798854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:212798854G>A	ENST00000294829.3	+	1	1066	c.635G>A	c.(634-636)gGa>gAa	p.G212E	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	212										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		AACCTTCAAGGAAAGGGGGAT	0.562000													38	96					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62547881	62547881	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:62547881G>A	ENST00000430451.2	+	4	1520	c.1323G>A	c.(1321-1323)cgG>cgA	p.R441R		NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	441	C2 1.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		ACGCTGCCCGGAAGATGACCC	0.567000													11	31					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47371532	47371532	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47371532C>T	ENST00000232766.5	+	4	513	c.493C>T	c.(493-495)Cag>Tag	p.Q165*	KLHL18_ENST00000455924.2_Nonsense_Mutation_p.Q53*	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	165	BACK.									endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CTTCATCCACCAGCACTTTGT	0.532000													29	88					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89391820	89391820	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:89391820G>A	ENST00000532352.1	+	0	436							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TGCACGAACTGAAGACTTCTT	0.368000													13	27					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73522254	73522254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73522254C>T	ENST00000418310.1	+	9	1311	c.1209C>T	c.(1207-1209)ttC>ttT	p.F403F	LIMK1_ENST00000336180.2_Silent_p.F373F|LIMK1_ENST00000538333.3_Silent_p.F339F			P53667	LIMK1_HUMAN	LIM domain kinase 1	373	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding	p.F373F(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				TGATCCGGTTCGACGAGGAGA	0.582000													3	4					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513509	99513509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:99513509G>A	ENST00000261037.3	+	5	1144	c.764G>A	c.(763-765)gGg>gAg	p.G255E	COL8A1_ENST00000273342.4_Missense_Mutation_p.G255E	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	255	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGTGTAAAGGGGCCTCCAGGG	0.647000													40	72					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115526432	115526432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115526432C>T	ENST00000361048.1	+	4	506	c.179C>T	c.(178-180)tCc>tTc	p.S60F	PLEKHS1_ENST00000369312.4_5'UTR|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.S54F	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		TTTAGTCTTTCCTATTATAAA	0.338000													32	86					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701923	56701923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56701923C>T	ENST00000586855.2	-	5	1074	c.761G>A	c.(760-762)gGg>gAg	p.G254E	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.G254E			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	254					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GGGTTCCTTCCCCTCCTTTGC	0.483000													38	81					0	0	1	0	0
SIRPB2	284759	broad.mit.edu	37	20	1459186	1459186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1459186C>T	ENST00000359801.3	-	3	554	c.518G>A	c.(517-519)gGa>gAa	p.G173E	SIRPB2_ENST00000537284.1_Missense_Mutation_p.G35E|SIRPB2_ENST00000381630.1_Missense_Mutation_p.G75E|SIRPB2_ENST00000444444.1_Missense_Mutation_p.G75E	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	173	Ig-like V-type 2.					integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GACAGTGTCTCCAGTGGTCCC	0.577000													19	50					0	0	1	0	0
OR11A1	26531	broad.mit.edu	37	6	29395302	29395302	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29395302G>A	ENST00000377149.1	-	5	589	c.117C>T	c.(115-117)ttC>ttT	p.F39F	OR11A1_ENST00000377147.2_Silent_p.F39F|OR11A1_ENST00000377148.1_Silent_p.F39F|OR5V1_ENST00000377154.1_Intron			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						CTATGATGATGAAGACATAGA	0.403000													32	53					0	0	1	0	0
FCN3	8547	broad.mit.edu	37	1	27700886	27700886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27700886G>A	ENST00000270879.4	-	2	153	c.148C>T	c.(148-150)Cca>Tca	p.P50S	FCN3_ENST00000354982.2_Missense_Mutation_p.P50S	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3	50	Collagen-like.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GGACTTCCTGGAGCTCCGGGA	0.617000													12	52					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176708876	176708876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176708876C>T	ENST00000367662.3	+	13	5077	c.3913C>T	c.(3913-3915)Cgt>Tgt	p.R1305C		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1305					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GACCGATGTCCGTGGAAGCAA	0.493000													25	59					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77409717	77409717	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:77409717G>A	ENST00000308488.6	-	7	2832	c.2530C>T	c.(2530-2532)Cga>Tga	p.R844*	RSF1_ENST00000360355.2_Nonsense_Mutation_p.R813*|RSF1_ENST00000480887.1_Nonsense_Mutation_p.R592*			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	844					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding	p.R844*(1)		breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CCAGTCCATCGAACTTTGCCT	0.368000													38	154					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46129491	46129491	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46129491C>T	ENST00000371383.2	-	5	1267		c.e5-1		ENPP5_ENST00000230565.3_Splice_Site			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)							extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						TGGTTGCCTACTGTAAAGAGA	0.353000													51	222					0	0	1	0	0
ZNF763	284390	broad.mit.edu	37	19	12089447	12089447	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12089447C>T	ENST00000343949.5	+	4	872	c.717C>T	c.(715-717)tcC>tcT	p.S239S	ZNF763_ENST00000358987.3_Silent_p.S236S|ZNF763_ENST00000545530.1_Silent_p.S114S|ZNF763_ENST00000590798.1_Silent_p.S256S|ZNF763_ENST00000538752.1_Silent_p.S256S	NM_001012753.1	NP_001012771.1			zinc finger protein 763											central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)	15						GTGTTAAATCCTTTAGTTATT	0.378000													28	84					0	0	1	0	0
HAP1	9001	broad.mit.edu	37	17	39890852	39890852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39890852C>T	ENST00000393939.2	-	1	44	c.35G>A	c.(34-36)gGg>gAg	p.G12E	HAP1_ENST00000310778.5_Missense_Mutation_p.G12E|HAP1_ENST00000347901.4_Missense_Mutation_p.G12E|HAP1_ENST00000341193.5_Missense_Mutation_p.G12E|JUP_ENST00000540235.1_Intron			P54257	HAP1_HUMAN	huntingtin-associated protein 1	12					brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			GAGCCGGCTCCCCGCGCAGCA	0.736000													3	5					0	0	1	0	0
SSX3	10214	broad.mit.edu	37	X	48206962	48206962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48206962C>T	ENST00000298396.2	-	7	596	c.544G>A	c.(544-546)Gat>Aat	p.D182N	SSX3_ENST00000376895.1_Missense_Mutation_p.D94N	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						TCCTCAGGATCGCTGATCTCT	0.483000													166	125					0	0	1	0	0
C4orf17	84103	broad.mit.edu	37	4	100463110	100463110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100463110G>A	ENST00000326581.4	+	9	1286	c.924G>A	c.(922-924)atG>atA	p.M308I		NM_032149.2	NP_115525.2	Q53FE4	CD017_HUMAN	chromosome 4 open reading frame 17	308										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		GAAATAATATGAAAATACCTG	0.388000													18	39					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47364527	47364527	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47364527G>A	ENST00000505841.1	-	0	309					NR_002788.2																						TGTCTTTTCAGGAGAATCTTG	0.478000													39	70					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649612	75649612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:75649612C>T	ENST00000361470.2	+	1	1567	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	430						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						TCCAAGTGTTCCCTTGTTTTG	0.572000													10	20					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175046902	175046902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175046902G>A	ENST00000239462.4	+	2	461	c.348G>A	c.(346-348)gaG>gaA	p.E116E		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	116					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix		p.E116D(1)		NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGAAGCTGGAGGAAGAGATGG	0.552000													12	37					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86542418	86542418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86542418C>T	ENST00000450689.2	-	14	2019	c.1834G>A	c.(1834-1836)Gaa>Aaa	p.E612K	KIAA1324L_ENST00000416314.1_Missense_Mutation_p.E445K|KIAA1324L_ENST00000444627.1_Intron|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.E372K|KIAA1324L_ENST00000490995.1_5'UTR	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	612						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					CCCGACTGTTCAGAACCGAGG	0.517000													12	58					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150267064	150267064	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150267064T>A	ENST00000461940.1	+	2	158	c.75T>A	c.(73-75)agT>agA	p.S25R	GIMAP4_ENST00000494750.1_Intron|GIMAP4_ENST00000255945.2_Intron			Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	20							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGCATTCAGTGCTCCCCAGA	0.592000													10	54					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105344435	105344435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105344435G>A	ENST00000369780.4	+	4	1201	c.792G>A	c.(790-792)gaG>gaA	p.E264E	NEURL_ENST00000369777.2_Silent_p.E247E	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		264					nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ACGGCGACGAGGCCGCGCCGG	0.761000													3	7					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195490982	195490982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:195490982G>A	ENST00000463781.3	-	11	14437	c.13978C>T	c.(13978-13980)Ctc>Ttc	p.L4660F	MUC4_ENST00000475231.1_Missense_Mutation_p.L4608F|MUC4_ENST00000349607.4_Missense_Mutation_p.L373F|MUC4_ENST00000346145.4_Missense_Mutation_p.L424F	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1417					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGGCACAGAGGTAGGGCTTG	0.657000													4	6					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20846357	20846357	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20846357G>A	ENST00000262715.5	-	39	5587	c.5547C>T	c.(5545-5547)gcC>gcT	p.A1849A	TEP1_ENST00000556935.1_Silent_p.A1741A|TEP1_ENST00000545983.1_Silent_p.A187A	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1849					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GCACATTGAAGGCCAAGGTAC	0.617000													31	77					0	0	1	0	0
JADE3	9767	broad.mit.edu	37	X	46913813	46913813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:46913813C>T	ENST00000218343.4	+	9	1524	c.1226C>T	c.(1225-1227)tCc>tTc	p.S409F	PHF16_ENST00000397189.1_Missense_Mutation_p.S409F	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		409					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						GAGTTCTATTCCTTGGTACGA	0.532000													23	21					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73545474	73545474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73545474G>A	ENST00000224721.6	+	43	5819	c.5814G>A	c.(5812-5814)gaG>gaA	p.E1938E		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1933	Cadherin 18.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACAACCCGGAGAATCCACGCA	0.612000													5	16					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	609451	609451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:609451C>T	ENST00000264555.5	+	14	4123	c.3995C>T	c.(3994-3996)tCg>tTg	p.S1332L	PHRF1_ENST00000533464.1_Missense_Mutation_p.S1328L|PHRF1_ENST00000416188.2_Missense_Mutation_p.S1331L|PHRF1_ENST00000413872.2_Missense_Mutation_p.S1330L	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1332							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						GAAGACCCTTCGCAGCCCCCA	0.672000													6	26					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146807307	146807307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:146807307G>A	ENST00000508784.1	-	4	1497	c.1270C>T	c.(1270-1272)Cat>Tat	p.H424Y	ZNF827_ENST00000379448.4_Missense_Mutation_p.H424Y|ZNF827_ENST00000513320.1_Missense_Mutation_p.H74Y			Q17R98	ZN827_HUMAN	zinc finger protein 827	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TGGTGCTGATGAACCTGACGG	0.502000													7	17					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3002618	3002618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3002618C>T	ENST00000381127.1	+	6	962	c.741C>T	c.(739-741)ctC>ctT	p.L247L	ARSF_ENST00000359361.2_Silent_p.L247L|ARSF_ENST00000537104.1_Silent_p.L247L	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	247						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACTGCCTCCTCATGCGGGGGC	0.507000													36	25					0	0	1	0	0
GRK5	2869	broad.mit.edu	37	10	121189921	121189921	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:121189921C>T	ENST00000392870.2	+	7	897	c.568C>T	c.(568-570)Cga>Tga	p.R190*	GRK5_ENST00000369108.3_Nonsense_Mutation_p.R85*	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	190	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		CAGGCAGTATCGAGTGCTAGG	0.458000													49	108					0	0	1	0	0
ARGLU1	55082	broad.mit.edu	37	13	107220265	107220265	+	Translation_Start_Site	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:107220265C>A	ENST00000400198.3	-	1	247	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_018011.3	NP_060481.3	Q9NWB6	ARGL1_HUMAN	arginine and glutamate rich 1	1										large_intestine(1)|lung(5)|pancreas(1)	7	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					GAGACCGGCCCATCCTTCCGG	0.697000													10	34					0.000978159	0.000979233	1	1	0
EPHA8	2046	broad.mit.edu	37	1	22927862	22927862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22927862C>T	ENST00000166244.3	+	16	2871	c.2799C>T	c.(2797-2799)ctC>ctT	p.L933L		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	933	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GTGGGGGCCTCACCGTGGGGG	0.677000													15	63					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32636038	32636038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:32636038C>T	ENST00000335185.5	-	16	1869	c.1826G>A	c.(1825-1827)gGg>gAg	p.G609E		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	609										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					TTCTCGAGTCCCTGGAAGCAA	0.333000													14	36					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003736	34003736	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34003736C>T	ENST00000374181.3	-	8	2320	c.2151G>A	c.(2149-2151)tgG>tgA	p.W717*	GRM4_ENST00000455714.2_Nonsense_Mutation_p.W577*|GRM4_ENST00000535756.1_Nonsense_Mutation_p.W584*|GRM4_ENST00000544773.1_Nonsense_Mutation_p.W548*|GRM4_ENST00000545715.1_Nonsense_Mutation_p.W409*|GRM4_ENST00000374177.3_Nonsense_Mutation_p.W601*|GRM4_ENST00000538487.1_Nonsense_Mutation_p.W717*	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	717					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CCACCACAAACCACACACAGA	0.642000													18	109					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27684701	27684701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27684701G>A	ENST00000374040.3	-	20	3122	c.2862C>T	c.(2860-2862)tgC>tgT	p.C954C	MAP3K6_ENST00000357582.2_Silent_p.C962C|MAP3K6_ENST00000493901.1_Silent_p.C962C			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	962					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CATAACTGAGGCAGCGCTTCG	0.607000											OREG0013282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	50					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474657	140474657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140474657G>A	ENST00000194155.4	+	1	431	c.283G>A	c.(283-285)Gag>Aag	p.E95K		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		95	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTGGACCGGGAGGAGCTGTG	0.512000													28	96					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234094533	234094533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234094533G>A	ENST00000359570.5	+	23	2284	c.2284G>A	c.(2284-2286)Ggg>Agg	p.G762R	INPP5D_ENST00000455936.2_Missense_Mutation_p.G526R|INPP5D_ENST00000450745.1_Missense_Mutation_p.G526R			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	774					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AGGAAGTGAGGGGGAGCTGGT	0.458000													7	23					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47841689	47841689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47841689G>A	ENST00000371764.4	+	6	655	c.646G>A	c.(646-648)Gaa>Aaa	p.E216K	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	216						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCAGTACGATGAAAACCTCTC	0.418000													37	120					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47628967	47628967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:47628967C>T	ENST00000546455.1	+	4	852	c.121C>T	c.(121-123)Cgc>Tgc	p.R41C	PCED1B_ENST00000432328.1_Missense_Mutation_p.R41C					PC-esterase domain containing 1B																		GCAGAAGGACCGCCTGCTCAC	0.597000													5	37					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211624	38211624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38211624C>T	ENST00000379705.3	-	11	3207	c.2350G>A	c.(2350-2352)Gaa>Aaa	p.E784K	TRPC4_ENST00000338947.5_Missense_Mutation_p.E611K|TRPC4_ENST00000358477.2_Missense_Mutation_p.E784K|TRPC4_ENST00000379681.3_Missense_Mutation_p.E789K|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379673.2_Missense_Mutation_p.E719K|TRPC4_ENST00000379679.1_Missense_Mutation_p.E611K|TRPC4_ENST00000355779.2_Intron			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	784	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CTATTACCTTCGCTATCACTC	0.413000													39	92					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294157	25294157	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25294157G>A	ENST00000400358.4	+	19	2298	c.2241G>A	c.(2239-2241)acG>acA	p.T747T	SGSM1_ENST00000400359.4_Silent_p.T802T	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	802	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						ACACCCCCACGGTGCTGCGAC	0.627000													13	66					0	0	1	0	0
ATRIP	84126	broad.mit.edu	37	3	48501206	48501206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48501206C>T	ENST00000412052.1	+	7	1129	c.667C>T	c.(667-669)Ctc>Ttc	p.L223F	ATRIP_ENST00000320211.3_Missense_Mutation_p.L316F|ATRIP_ENST00000346691.4_Missense_Mutation_p.L316F|ATRIP_ENST00000357105.6_Missense_Mutation_p.L189F	NM_001271023.1	NP_001257952.1	Q8WXE1	ATRIP_HUMAN	ATR interacting protein	316					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)	22				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GATAAACCTGCTCCTGAAGCA	0.507000								Other conserved DNA damage response genes					49	210					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168096465	168096465	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168096465G>A	ENST00000409195.1	+	6	1048	c.959G>A	c.(958-960)gGa>gAa	p.G320E	XIRP2_ENST00000409605.1_Missense_Mutation_p.G98E|XIRP2_ENST00000409728.1_Missense_Mutation_p.G353E|XIRP2_ENST00000420519.1_Missense_Mutation_p.G353E|XIRP2_ENST00000295237.9_Missense_Mutation_p.G320E|XIRP2_ENST00000409273.1_Missense_Mutation_p.G98E|XIRP2_ENST00000409756.2_Missense_Mutation_p.G320E|XIRP2_ENST00000409043.1_Missense_Mutation_p.G320E	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	145					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATGTTCATGGAACAGAAATG	0.388000													22	35					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70933760	70933760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70933760C>T	ENST00000334414.6	-	24	5681	c.5637G>A	c.(5635-5637)agG>agA	p.R1879R	PTPRB_ENST00000550358.1_Silent_p.R1791R|PTPRB_ENST00000261266.5_Silent_p.R1661R|PTPRB_ENST00000451516.2_Silent_p.R1571R|PTPRB_ENST00000538708.1_Silent_p.R1571R|PTPRB_ENST00000550857.1_Silent_p.R1571R	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1661	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.R1661S(2)|p.R1879S(1)		breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATGGTCGATCCCTACGAATGC	0.408000													16	36					0	0	1	0	0
TRBV25-1	28562	broad.mit.edu	37	7	142378908	142378908	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142378908G>A	ENST00000390398.3	+	0	213																											CAAGATCCAGGAATGGAACTA	0.438000													49	110					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624553	123624553	+	Missense_Mutation	SNP	C	C	T	rs140203672	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123624553C>T	ENST00000327930.2	-	1	700	c.674G>A	c.(673-675)cGa>cAa	p.R225Q		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGAAGGAATTCGTAGGATTGC	0.473000													38	76					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13920608	13920608	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13920608C>T	ENST00000265104.4	-	6	883	c.779G>A	c.(778-780)tGg>tAg	p.W260*		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	260	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTGTTTGATCCATACTTTCAT	0.398000									Kartagener syndrome				32	100					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17422640	17422640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17422640G>A	ENST00000470360.1	+	14	2196	c.2079G>A	c.(2077-2079)aaG>aaA	p.K693K	SLC7A2_ENST00000398090.3_Silent_p.K693K|SLC7A2_ENST00000522656.1_Silent_p.K654K|SLC7A2_ENST00000494857.1_Silent_p.K654K|SLC7A2_ENST00000004531.10_Silent_p.K694K			P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	654					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	TCCATGAAAAGACAAGTGAAT	0.433000													13	26					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29008201	29008201	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29008201G>A	ENST00000282397.4	-	5	921	c.670C>T	c.(670-672)Cga>Tga	p.R224*	FLT1_ENST00000541932.1_Nonsense_Mutation_p.R224*|FLT1_ENST00000539099.1_Nonsense_Mutation_p.R224*	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	224					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TTACTTTGTCGATGTGTGAGA	0.353000													24	77					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189863437	189863437	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189863437G>A	ENST00000304636.3	+	29	2185	c.2015G>A	c.(2014-2016)gGa>gAa	p.G672E	COL3A1_ENST00000317840.5_Missense_Mutation_p.G672E	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	672	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGAGCTCCAGGAGGCAAGGTA	0.383000													21	41					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254511	30254511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:30254511C>T	ENST00000361644.2	+	5	1207	c.470C>T	c.(469-471)tCt>tTt	p.S157F	MAGEB3_ENST00000378986.1_Missense_Mutation_p.S157F	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	157	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						AAAAAAGCTTCTTTCAACATG	0.373000													52	20					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46125901	46125901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46125901G>A	ENST00000295452.4	-	1	197	c.30C>T	c.(28-30)tcC>tcT	p.S10S		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	10					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		GAAGAAAAGGGGAGAAGAGAA	0.473000													6	48					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113496530	113496530	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113496530G>A	ENST00000416899.2	+	6	754		c.e6-1		MUSK_ENST00000374448.4_Splice_Site|MUSK_ENST00000189978.5_Splice_Site			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						CTTCCTAACAGTTTTTGCCAG	0.507000													5	17					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45387767	45387767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45387767C>T	ENST00000389039.6	-	31	4492	c.4107G>A	c.(4105-4107)gaG>gaA	p.E1369E	DUOX2_ENST00000603300.1_Silent_p.E1369E			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1369	FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CCTGATGGCCCTCTCCAAACG	0.562000													23	60					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759414	121759414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121759414G>A	ENST00000261367.7	+	6	2551	c.1123G>A	c.(1123-1125)Gaa>Aaa	p.E375K	SNCAIP_ENST00000261368.8_Missense_Mutation_p.E328K|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E328K|SNCAIP_ENST00000503116.2_Missense_Mutation_p.E375K|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E375K			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	328					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CATTGTTAAAGAAGGACAGAT	0.408000													20	71					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38723748	38723748	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38723748G>A	ENST00000359357.3	+	8	1011	c.756_splice	c.e8-1	p.V253_splice	DNAH8_ENST00000441566.1_Splice_Site_p.V253_splice|DNAH8_ENST00000449981.2_Splice_Site_p.V470_splice					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TCAATGTTAGGTTTCCATGGC	0.303000													23	52					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922361	24922361	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922361A>G	ENST00000329468.2	+	1	1821	c.1347A>G	c.(1345-1347)aaA>aaG	p.K449K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCACACCAAAAATGGATGAGA	0.507000													55	113					0	0	1	0	0
ELAVL3	1995	broad.mit.edu	37	19	11567934	11567934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11567934C>T	ENST00000359227.3	-	6	1167	c.743G>A	c.(742-744)gGc>gAc	p.G248D	ELAVL3_ENST00000438662.2_Missense_Mutation_p.G248D	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	248				G -> A (in Ref. 4; BAA21838).	cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						CCTCTTGACGCCGTAGGCCAT	0.647000													3	15					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48119606	48119606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48119606G>A	ENST00000311303.3	-	27	4071	c.3726C>T	c.(3724-3726)ctC>ctT	p.L1242L	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000532355.1_5'UTR|ABCC12_ENST00000448542.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1242	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				ATTTTTCTGGGAGTTTCATTA	0.408000													28	129					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105252525	105252525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:105252525C>T	ENST00000306107.5	+	5	1038	c.538C>T	c.(538-540)Ctt>Ttt	p.L180F	ALCAM_ENST00000486979.2_Missense_Mutation_p.L129F|ALCAM_ENST00000472644.2_Missense_Mutation_p.L180F|ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000389927.4_5'UTR	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	180	Ig-like V-type 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						GCTACATCCCCTTGAAGGAGG	0.448000													29	90					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38884057	38884057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38884057G>A	ENST00000274276.3	+	5	949	c.547G>A	c.(547-549)Ggg>Agg	p.G183R	OSMR_ENST00000502536.1_Missense_Mutation_p.G183R	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	183					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TTATTTGGAAGGGAAACAGAT	0.363000													28	106					0	0	1	0	0
MED1	5469	broad.mit.edu	37	17	37580070	37580070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37580070G>A	ENST00000300651.6	-	12	1079	c.856C>T	c.(856-858)Cct>Tct	p.P286S	MED1_ENST00000394287.3_Missense_Mutation_p.P286S	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	286	Interaction with ESR1.|Interaction with the Mediator complex and THRA.|Interaction with the Mediator complex.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GAGAAGGAAGGGGTCCTTCAA	0.403000										HNSCC(31;0.082)			28	29					0	0	1	0	0
PIK3C3	5289	broad.mit.edu	37	18	39542544	39542544	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:39542544C>T	ENST00000262039.4	+	3	434	c.348C>T	c.(346-348)ccC>ccT	p.P116P	PIK3C3_ENST00000586545.1_Silent_p.P116P|PIK3C3_ENST00000398870.3_Silent_p.P53P	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	116					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						TGTATGGTCCCGGAAAAGCAG	0.483000										TSP Lung(28;0.18)			22	83					0	0	1	0	0
GDPGP1	390637	broad.mit.edu	37	15	90784905	90784905	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90784905C>T	ENST00000558017.1	+	4	1185	c.765C>T	c.(763-765)ttC>ttT	p.F255F	GDPGP1_ENST00000329600.6_Silent_p.F255F	NM_001013657.2	NP_001013679.2	Q6ZNW5	VTC2_HUMAN	GDP-D-glucose phosphorylase 1	255					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity										CTCCTGGCTTCCTCTTTTACA	0.577000													12	72					0	0	1	0	0
RSL1D1	26156	broad.mit.edu	37	16	11931783	11931783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11931783G>A	ENST00000571133.1	-	9	1406	c.1334C>T	c.(1333-1335)tCg>tTg	p.S445L	RSL1D1_ENST00000542106.1_Missense_Mutation_p.S225L	NM_015659.2	NP_056474.2	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	445					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	15						tttccccagcgaaggactttt	0.478000													151	281					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69796941	69796941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69796941C>T	ENST00000251566.4	-	4	1046	c.1016G>A	c.(1015-1017)gGa>gAa	p.G339E	UGT2A3_ENST00000420231.2_Missense_Mutation_p.G50E	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	339						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TGGTTTTTTTCCTTTGTACCT	0.358000													24	51					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94674845	94674845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94674845C>T	ENST00000304338.3	+	3	390	c.236C>T	c.(235-237)cCa>cTa	p.P79L	PPP4R4_ENST00000328839.3_Missense_Mutation_p.P79L|PPP4R4_ENST00000555690.1_3'UTR	NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	79						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GCAAATCTCCCATTTTTGATG	0.378000													15	51					0	0	1	0	0
RAB2B	84932	broad.mit.edu	37	14	21930572	21930572	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21930572G>A	ENST00000397762.1	-	7	580	c.480C>T	c.(478-480)ttC>ttT	p.F160F	RAB2B_ENST00000461909.1_5'UTR	NM_001163380.1|NM_032846.3	NP_001156852.1|NP_116235.2	Q8WUD1	RAB2B_HUMAN	RAB2B, member RAS oncogene family	160					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		CTGTGTTAATGAAGGCCTGAA	0.358000													42	107					0	0	1	0	0
UPK1B	7348	broad.mit.edu	37	3	118909895	118909895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:118909895G>A	ENST00000264234.3	+	5	561	c.412G>A	c.(412-414)Gat>Aat	p.D138N	UPK1B_ENST00000460625.1_Missense_Mutation_p.D130N|UPK1B_ENST00000497685.1_Missense_Mutation_p.D58N	NM_006952.3	NP_008883.2	O75841	UPK1B_HUMAN	uroplakin 1B	138					epithelial cell differentiation	integral to membrane	structural molecule activity			breast(1)|endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	14				GBM - Glioblastoma multiforme(114;0.222)		TCCAAACAATGATGACCAGTG	0.478000													122	255					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73535261	73535261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73535261C>T	ENST00000418310.1	+	15	1855	c.1753C>T	c.(1753-1755)Cgc>Tgc	p.R585C	LIMK1_ENST00000336180.2_Missense_Mutation_p.R555C|LIMK1_ENST00000538333.3_Missense_Mutation_p.R521C			P53667	LIMK1_HUMAN	LIM domain kinase 1	555	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				CTACCTGCCCCGCACCATGGA	0.647000													74	130					0	0	1	0	0
ZC3H11A	9877	broad.mit.edu	37	1	203798606	203798606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203798606C>T	ENST00000545588.1	+	5	4153	c.326C>T	c.(325-327)cCa>cTa	p.P109L	ZC3H11A_ENST00000367214.1_Missense_Mutation_p.P109L|ZC3H11A_ENST00000367212.3_Missense_Mutation_p.P109L|ZC3H11A_ENST00000332127.4_Missense_Mutation_p.P109L|ZC3H11A_ENST00000367210.1_Missense_Mutation_p.P109L	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	109							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTGAGTCACCAGAAGAGGAA	0.448000													31	80					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50366977	50366977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50366977G>A	ENST00000315520.5	+	1	358	c.21G>A	c.(19-21)ggG>ggA	p.G7G	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	7					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						TGGAGCCAGGGGGACGTGGCT	0.592000													8	43					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55144467	55144467	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55144467G>A	ENST00000396331.1	+	8	1316	c.958_splice	c.e8-1	p.G320_splice	LILRB1_ENST00000448689.1_Splice_Site_p.G320_splice|LILRB1_ENST00000434867.2_Splice_Site_p.G320_splice|LILRB1_ENST00000396332.4_Splice_Site_p.G320_splice|LILRB1_ENST00000427581.2_Splice_Site_p.G356_splice|LILRB1_ENST00000324602.7_Splice_Site_p.G320_splice|LILRB1_ENST00000418536.2_Splice_Site_p.G320_splice|LILRB1_ENST00000396317.1_Splice_Site_p.G320_splice|LILRB1_ENST00000396321.2_Splice_Site_p.G320_splice|LILRB1_ENST00000396315.1_Splice_Site_p.G320_splice|LILRB1_ENST00000396327.3_Splice_Site_p.G320_splice	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	320	Ig-like C2-type 4.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TTCTCTCCAGGACAGTTCTAT	0.607000										HNSCC(37;0.09)			14	87					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40746003	40746003	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40746003C>T	ENST00000216194.7	+	2	377	c.321C>T	c.(319-321)caC>caT	p.H107H	ADSL_ENST00000342312.6_Silent_p.H107H|ADSL_ENST00000454266.2_Silent_p.H107H	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	107					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						GCATTATTCACCTTGGTGCTA	0.423000													21	88					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187206877	187206877	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187206877C>T	ENST00000264692.4	+	12	1567	c.1234C>T	c.(1234-1236)Caa>Taa	p.Q412*	F11_ENST00000403665.2_Nonsense_Mutation_p.Q464*			P03951	FA11_HUMAN	coagulation factor XI	464	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	CTTTGGGGTTCAAGAAATAAT	0.378000													56	92					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49697935	49697935	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49697935C>T	ENST00000296452.4	+	6	8771	c.8657C>T	c.(8656-8658)cCc>cTc	p.P2886L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2886					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCGTTGCCACCCAACAGCCTG	0.657000													40	141					0	0	1	0	0
SPATA31A3	727830	broad.mit.edu	37	9	40702809	40702809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:40702809G>A	ENST00000356699.5	+	4	495	c.466G>A	c.(466-468)Gat>Aat	p.D156N	SPATA31A3_ENST00000463536.1_3'UTR	NM_001083124.1	NP_001076593.1			SPATA31 subfamily A, member 3									p.D156N(2)									AGCTTCCCCGGATCCTCAAGC	0.597000													56	260					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620855	7620855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:7620855C>T	ENST00000486284.1	+	8	2536	c.2262C>T	c.(2260-2262)ctC>ctT	p.L754L	GRM7_ENST00000403881.1_Silent_p.L754L|GRM7_ENST00000389336.4_Silent_p.L754L|GRM7_ENST00000402647.2_Silent_p.L754L|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000357716.4_Silent_p.L754L	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	754					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TTACAGATCTCCAAATCATTT	0.443000													39	79					0	0	1	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3392325	3392325	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:3392325C>G	ENST00000324266.5	+	2	1126	c.931C>G	c.(931-933)Ctt>Gtt	p.L311V	TRAPPC12_ENST00000382110.2_Missense_Mutation_p.L311V	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	311							binding										CGACGCCTGGCTTCCCGGCGA	0.672000													10	32					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16060702	16060702	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16060702G>A	ENST00000322107.1	+	1	885	c.885G>A	c.(883-885)agG>agA	p.R295R		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						TCAGCCTAAGGAACAAGGAGC	0.438000													69	104					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158581078	158581078	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158581078G>A	ENST00000368148.3	-	52	7416	c.7236C>T	c.(7234-7236)ttC>ttT	p.F2412F	SPTA1_ENST00000368147.3_Silent_p.F2409F	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2412				GRSHLSGYDYVGFTNSYFGN -> VEAISLAMTTLASPIPT LATNKQLLVDRRKS (in Ref. 1; AAA60577/ AAA60994).	actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGGAATTGGTGAAGCCAACGT	0.483000													15	45					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86537848	86537848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86537848C>T	ENST00000450689.2	-	17	2556	c.2371G>A	c.(2371-2373)Gaa>Aaa	p.E791K	KIAA1324L_ENST00000416314.1_Missense_Mutation_p.E624K|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.E720K|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.E551K	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	791						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					AATGTGGTTTCAACTGTGACT	0.289000													34	63					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12496026	12496026	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:12496026C>T	ENST00000535902.1	-	2	786	c.223_splice	c.e2+1	p.G75_splice	MANSC1_ENST00000396349.3_Splice_Site_p.G41_splice			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	75	MANSC.					integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CACTATTTACCTGATATGTTT	0.418000													37	78					0	0	1	0	0
C1GALT1	56913	broad.mit.edu	37	7	7283191	7283191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:7283191C>T	ENST00000436587.2	+	4	1148	c.925C>T	c.(925-927)Cac>Tac	p.H309Y	C1GALT1_ENST00000223122.2_Missense_Mutation_p.H309Y	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	309					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		AGTTTCTTTTCACTATGTTGA	0.358000													34	160					0	0	1	0	0
SMAD6	4091	broad.mit.edu	37	15	67073803	67073803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:67073803C>T	ENST00000288840.5	+	4	2452	c.1421C>T	c.(1420-1422)cCc>cTc	p.P474L	SMAD6_ENST00000338426.4_Missense_Mutation_p.P213L	NM_005585.4	NP_005576.3	O43541	SMAD6_HUMAN	SMAD family member 6	474	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			lung(1)|skin(1)	2						GGCTGGGGGCCCTGCTACTCC	0.716000													7	32					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75289544	75289544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75289544G>A	ENST00000339859.4	-	14	2054	c.1954C>T	c.(1954-1956)Ccc>Tcc	p.P652S	USP54_ENST00000428547.1_Missense_Mutation_p.P502S|USP54_ENST00000497106.1_5'UTR|USP54_ENST00000319786.7_Missense_Mutation_p.P652S|USP54_ENST00000408019.1_Missense_Mutation_p.P652S|USP54_ENST00000394811.2_5'UTR			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	652					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					ATTAGTCGGGGGTGCTGCTCT	0.557000											OREG0020266	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	199					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38963059	38963059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38963059G>A	ENST00000357387.3	-	17	1515	c.1485C>T	c.(1483-1485)gaC>gaT	p.D495D	RICTOR_ENST00000296782.5_Silent_p.D495D	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	495					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					GAATAATGTGGTCTAAATGAA	0.393000													27	86					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161132108	161132108	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161132108G>C	ENST00000308192.9	+	4	355		c.e4-1		PLG_ENST00000366924.2_Splice_Site|PLG_ENST00000462918.1_Splice_Site	NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen						extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CTTCCCTTCAGTGTATCTCTC	0.453000													20	24					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18788727	18788727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18788727G>A	ENST00000406451.3	+	14	2150	c.2000G>A	c.(1999-2001)cGa>cAa	p.R667Q	HDAC9_ENST00000401921.1_Missense_Mutation_p.R626Q|HDAC9_ENST00000441542.2_Missense_Mutation_p.R670Q|HDAC9_ENST00000432645.2_Missense_Mutation_p.R667Q	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	667	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity	p.R670L(2)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	ATCTGGTCACGACTGCAAGAA	0.438000													7	16					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8807902	8807902	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8807902C>T	ENST00000324436.3	-	1	1270	c.1150G>A	c.(1150-1152)Ggc>Agc	p.G384S		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	384						cytoplasm|cytoskeleton		p.G384S(1)		NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						AGGATGGAGCCCCCGATCCAT	0.652000													14	44					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82644813	82644813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:82644813C>T	ENST00000533655.1	+	6	2645	c.2433C>T	c.(2431-2433)ttC>ttT	p.F811F	C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000329143.3_Silent_p.F510F|C11orf82_ENST00000430323.2_Silent_p.F811F|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	811					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TAAGGATTTTCCCTGAAAATG	0.368000													14	32					0	0	1	0	0
HSD11B1	3290	broad.mit.edu	37	1	209879200	209879200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209879200G>A	ENST00000367028.2	+	3	302	c.133G>A	c.(133-135)Ggg>Agg	p.G45R	HSD11B1_ENST00000367027.3_Missense_Mutation_p.G45R|HSD11B1_ENST00000261465.1_Missense_Mutation_p.G45R|RP1-28O10.1_ENST00000441672.1_RNA	NM_001206741.1	NP_001193670.1	P28845	DHI1_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1	45					glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	16				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	GGCCAGCAAAGGGATCGGAAG	0.502000													34	69					0	0	1	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51768752	51768752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51768752G>A	ENST00000316401.7	+	3	534	c.153G>A	c.(151-153)atG>atA	p.M51I	SIGLECL1_ENST00000597824.1_Intron|SIGLECL1_ENST00000593968.1_Intron|CTD-3187F8.2_ENST00000597569.1_RNA	NM_173635.1	NP_775906.1			SIGLEC family like 1																		TGGATGGCATGGATGGCAGCC	0.572000													32	56					0	0	1	0	0
SMAD7	4092	broad.mit.edu	37	18	46447991	46447991	+	Silent	SNP	G	G	A	rs143946125	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:46447991G>A	ENST00000262158.2	-	4	1318	c.1032C>T	c.(1030-1032)tcC>tcT	p.S344S	SMAD7_ENST00000591805.1_Silent_p.S129S|SMAD7_ENST00000585986.1_5'UTR|SMAD7_ENST00000589634.1_Silent_p.S343S	NM_001190821.1|NM_005904.3	NP_001177750.1|NP_005895.1	O15105	SMAD7_HUMAN	SMAD family member 7	344	MH2.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	10	Colorectal(1;0.0518)					CCAGTGTGGCGGACTTGATGA	0.582000													13	29					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182497	100182497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100182497G>A	ENST00000554176.1	+	4	1075	c.409G>A	c.(409-411)Gag>Aag	p.E137K	CYP46A1_ENST00000423126.2_Missense_Mutation_p.E193K|CYP46A1_ENST00000261835.3_Missense_Mutation_p.E290K			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	290					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCAGGACGACGAGGGTCTGCT	0.522000													21	89					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272723	81272723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81272723G>A	ENST00000520547.2	+	1	367	c.318G>A	c.(316-318)ggG>ggA	p.G106G		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	106					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			AGGACAGCGGGGAGGTACCAG	0.532000													9	99					0	0	1	0	0
C1orf192	257177	broad.mit.edu	37	1	161334873	161334873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161334873C>T	ENST00000367974.1	-	5	421	c.416G>A	c.(415-417)cGa>cAa	p.R139Q		NM_001013625.2	NP_001013647.2	Q5VTH2	CA192_HUMAN	chromosome 1 open reading frame 192	139										endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10	all_cancers(52;4.64e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GGTTGGACTTCGTGCTTGTTG	0.488000													32	87					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50750524	50750524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50750524G>A	ENST00000300589.2	+	5	2594	c.2489G>A	c.(2488-2490)cGa>cAa	p.R830Q		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	830					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				ATCTCAGACCGAGGCATCTGC	0.428000													17	28					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055528	75055528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75055528C>T	ENST00000326665.5	-	12	2181	c.1963G>A	c.(1963-1965)Gag>Aag	p.E655K	C1orf173_ENST00000420661.2_Missense_Mutation_p.E458K|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	655	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGCTTGGTCTCCACATCTGCT	0.403000													22	95					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921933	24921933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24921933C>T	ENST00000329468.2	+	1	1393	c.919C>T	c.(919-921)Cct>Tct	p.P307S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TGATGAGAAGCCTTTCTGTAT	0.587000													25	78					0	0	1	0	0
TTC12	54970	broad.mit.edu	37	11	113221964	113221964	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113221964C>T	ENST00000393020.1	+	15	1656	c.1251C>T	c.(1249-1251)ttC>ttT	p.F417F	TTC12_ENST00000483239.2_Silent_p.F423F|TTC12_ENST00000529221.1_Silent_p.F417F|TTC12_ENST00000314756.3_Silent_p.F417F|TTC12_ENST00000478125.1_3'UTR			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	417							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TCAACAGATTCCAAGTCTGGT	0.423000													14	45					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314000	54314000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54314000C>T	ENST00000324134.6	-	3	1081	c.913G>A	c.(913-915)Gat>Aat	p.D305N	NLRP12_ENST00000354278.3_Missense_Mutation_p.D305N|NLRP12_ENST00000391772.1_Missense_Mutation_p.D305N|NLRP12_ENST00000351894.4_Missense_Mutation_p.D305N|NLRP12_ENST00000391775.3_Missense_Mutation_p.D305N|NLRP12_ENST00000535162.1_Missense_Mutation_p.D305N|NLRP12_ENST00000345770.5_Missense_Mutation_p.D305N|NLRP12_ENST00000391773.1_Missense_Mutation_p.D305N	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	305	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCCTGAGGATCGTGGAAAGAA	0.582000													6	66					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531100	50531100	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50531100G>A	ENST00000374144.3	+	3	798	c.510G>A	c.(508-510)ctG>ctA	p.L170L	C10orf71_ENST00000323868.4_Silent_p.L170L			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	170										endometrium(1)	1						CTCCGGCTCTGAAAAATCCTC	0.498000													11	35					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256431	140256431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140256431C>T	ENST00000398631.2	+	1	1374	c.1374C>T	c.(1372-1374)ccC>ccT	p.P458P	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGCGCAGCCCGAGTACACAG	0.657000													31	152					0	0	1	0	0
RAB30	27314	broad.mit.edu	37	11	82693265	82693265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:82693265G>A	ENST00000533486.1	-	6	838	c.554C>T	c.(553-555)tCa>tTa	p.S185L	RAB30_ENST00000260056.2_Missense_Mutation_p.S185L|RAB30_ENST00000527633.1_Missense_Mutation_p.S185L|RP11-659G9.3_ENST00000527550.1_RNA|RAB30_ENST00000534141.1_3'UTR	NM_014488.3	NP_055303.2	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	185					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						AGGTAAGGGTGAGGATACATT	0.448000													45	93					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751506	140751506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140751506C>T	ENST00000576222.1	+	1	1676	c.1545C>T	c.(1543-1545)ttC>ttT	p.F515F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGTGTTCGCGCAGCGAG	0.672000													14	70					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646787	57646787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57646787G>A	ENST00000269834.1	-	5	1303	c.918C>T	c.(916-918)ccC>ccT	p.P306P		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TACATTGAAAGGGTTTTTGTC	0.383000													45	149					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208940	140208940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140208940G>A	ENST00000529310.1	+	1	1378	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.E422K|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCGGCCTATGAGTTGGTGGT	0.617000													73	214					0	0	1	0	0
GPR22	2845	broad.mit.edu	37	7	107115332	107115332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107115332G>A	ENST00000304402.4	+	3	2170	c.827G>A	c.(826-828)gGt>gAt	p.G276D	COG5_ENST00000347053.3_Intron|COG5_ENST00000475638.2_Intron|COG5_ENST00000297135.3_Intron|COG5_ENST00000393603.2_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	276						integral to plasma membrane	G-protein coupled receptor activity			large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						CAAAGCAGTGGTGGGAGAAAT	0.433000													26	69					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110662232	110662232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110662232C>T	ENST00000394634.2	-	13	1776	c.1569G>A	c.(1567-1569)ggG>ggA	p.G523G	CFI_ENST00000512148.1_Silent_p.G516G|CFI_ENST00000394635.3_Silent_p.G531G	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	523	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CTCCAGAGTCCCCTTTACAGG	0.463000													86	204					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152695833	152695833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152695833G>A	ENST00000360283.6	-	13	1521	c.1264C>T	c.(1264-1266)Cta>Tta	p.L422L	CACNB4_ENST00000427385.1_Silent_p.L437L|CACNB4_ENST00000534999.1_Silent_p.L421L|CACNB4_ENST00000201943.5_Silent_p.L393L|CACNB4_ENST00000539935.1_Silent_p.L455L|CACNB4_ENST00000397327.2_Silent_p.L408L			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	455					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GAGGTCATTAGACTTCGTCTT	0.418000													46	103					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6472810	6472810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6472810C>T	ENST00000263125.5	-	17	2026	c.1927G>A	c.(1927-1929)Gaa>Aaa	p.E643K	PRKCQ_ENST00000539722.1_Missense_Mutation_p.E518K|PRKCQ_ENST00000397176.2_Missense_Mutation_p.E580K	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	643	AGC-kinase C-terminal.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TCCTTCCGTTCAAGTTCCTCC	0.602000													23	68					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41976634	41976634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:41976634C>T	ENST00000372584.1	-	8	7720	c.6706G>A	c.(6706-6708)Gag>Aag	p.E2236K	HIVEP3_ENST00000429157.2_Missense_Mutation_p.E2236K|HIVEP3_ENST00000372583.1_Missense_Mutation_p.E2237K|HIVEP3_ENST00000247584.5_Missense_Mutation_p.E2237K|HIVEP3_ENST00000460604.1_5'UTR	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	2237					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TCCTGGGCCTCCCGGGCCCCT	0.697000													14	52					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40746004	40746004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40746004C>T	ENST00000216194.7	+	2	378	c.322C>T	c.(322-324)Ctt>Ttt	p.L108F	ADSL_ENST00000342312.6_Missense_Mutation_p.L108F|ADSL_ENST00000454266.2_Missense_Mutation_p.L108F	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	108					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						CATTATTCACCTTGGTGCTAC	0.423000													21	88					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71906323	71906323	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71906323G>A	ENST00000258104.3	+	52	6181	c.5904G>A	c.(5902-5904)tgG>tgA	p.W1968*	DYSF_ENST00000410041.1_Nonsense_Mutation_p.W1986*|DYSF_ENST00000429174.2_Nonsense_Mutation_p.W1989*|DYSF_ENST00000409744.1_Nonsense_Mutation_p.W1976*|DYSF_ENST00000410020.3_Nonsense_Mutation_p.W2007*|DYSF_ENST00000394120.2_Nonsense_Mutation_p.W1969*|DYSF_ENST00000409366.1_Nonsense_Mutation_p.W1990*|DYSF_ENST00000409582.3_Nonsense_Mutation_p.W2006*|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Nonsense_Mutation_p.W1999*|DYSF_ENST00000409651.1_Nonsense_Mutation_p.W2000*|DYSF_ENST00000409762.1_Nonsense_Mutation_p.W1985*	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1968						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TGAAGGGCTGGTGGCCCTGTG	0.522000													15	48					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103444462	103444462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103444462C>T	ENST00000358392.2	-	34	3016	c.2699G>A	c.(2698-2700)cGa>cAa	p.R900Q	COL11A1_ENST00000512756.1_Missense_Mutation_p.R772Q|COL11A1_ENST00000353414.4_Missense_Mutation_p.R849Q|COL11A1_ENST00000370096.3_Missense_Mutation_p.R888Q	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	888	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCTTGAACCTCGAGGACCCTG	0.388000													24	90					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4153782	4153782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4153782G>A	ENST00000404826.2	+	25	3838	c.3699G>A	c.(3697-3699)ctG>ctA	p.L1233L	SDK1_ENST00000389531.3_Silent_p.L1233L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1233	Fibronectin type-III 6.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTGACCGGCTGGAGAGAGAAT	0.612000													12	42					0	0	1	0	0
FMR1	2332	broad.mit.edu	37	X	147026416	147026416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:147026416C>T	ENST00000218200.8	+	14	1665	c.1436C>T	c.(1435-1437)tCt>tTt	p.S479F	FMR1_ENST00000370470.1_Intron|FMR1_ENST00000439526.2_Missense_Mutation_p.S477F|FMR1_ENST00000440235.2_Missense_Mutation_p.S147F|FMR1_ENST00000370471.3_Intron|FMR1_ENST00000370475.4_Missense_Mutation_p.S500F|FMR1_ENST00000370477.1_Intron	NM_001185076.1|NM_001185082.1	NP_001172005.1|NP_001172011.1	Q06787	FMR1_HUMAN	fragile X mental retardation 1	500	Interaction with RANBP9.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			NS(1)|breast(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	35	Acute lymphoblastic leukemia(192;6.56e-05)					TCAAATGCTTCTGAAACAGAA	0.428000									Fragile X syndrome				4	23					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767500	105767500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:105767500C>T	ENST00000374798.3	+	5	657	c.587C>T	c.(586-588)tCa>tTa	p.S196L	CYLC2_ENST00000487798.1_Missense_Mutation_p.S196L	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	196	3 X approximate tandem repeats.|31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				aaaaaggaTTCAAACAAAGGC	0.373000													6	30					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96059665	96059665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:96059665C>T	ENST00000343702.4	-	9	2119	c.1671G>A	c.(1669-1671)ctG>ctA	p.L557L	NTN4_ENST00000344911.4_Silent_p.L520L|NTN4_ENST00000553059.1_Silent_p.L534L|NTN4_ENST00000538383.1_Silent_p.L520L|PGAM1P5_ENST00000552554.1_RNA	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	557	NTR.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						GGAAAATCTTCAGTTTGGTAG	0.363000													19	70					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24669185	24669185	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24669185G>A	ENST00000361548.4	+	10	1438	c.1206_splice	c.e10-1	p.G403_splice	GRHL3_ENST00000350501.5_Splice_Site_p.G403_splice|GRHL3_ENST00000356046.2_Splice_Site_p.G357_splice|GRHL3_ENST00000342072.4_Splice_Site_p.G310_splice|GRHL3_ENST00000236255.4_Splice_Site_p.G408_splice	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	403					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CCCCTGCAGGGAGCTGAGAGG	0.587000													39	112					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76503739	76503739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76503739G>A	ENST00000389840.5	-	28	4497	c.4373C>T	c.(4372-4374)tCc>tTc	p.S1458F	DNAH17_ENST00000585328.1_Missense_Mutation_p.S1459F					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGGTACTTGGACATCATCAG	0.607000													5	34					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220333389	220333389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220333389G>A	ENST00000312358.7	+	11	3364	c.3232G>A	c.(3232-3234)Ggc>Agc	p.G1078S	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1078	Ig-like 5.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GGTGTTGGAGGGCCGAGCTGC	0.637000													31	53					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149502526	149502526	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149502526C>T	ENST00000378016.2	+	0	8339							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCTGGACTTCCTGGTCCTCC	0.667000													27	42					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	31086160	31086160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:31086160C>T	ENST00000597505.1	-	18	2446	c.2447G>A	c.(2446-2448)aGt>aAt	p.S816N	DCDC1_ENST00000437348.1_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GTTGCTGGCACTTTCTTGCAG	0.413000													33	36					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123264747	123264747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123264747C>T	ENST00000451558.1	+	10	1097	c.576C>T	c.(574-576)atC>atT	p.I192I	ASB15_ENST00000434204.1_Silent_p.I192I|ASB15_ENST00000451215.1_Silent_p.I192I|RP11-390E23.3_ENST00000429396.1_RNA|RP11-390E23.3_ENST00000440504.1_RNA|ASB15_ENST00000275699.3_Silent_p.I192I|RP11-390E23.3_ENST00000418409.1_RNA|ASB15_ENST00000540573.1_Silent_p.I192I			Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box containing 15	192					intracellular signal transduction					breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(3)	12						GAAAAGATATCGTAGCTCTGC	0.517000											OREG0018282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	84					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53165672	53165672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53165672C>T	ENST00000332411.2	-	6	1299	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	416	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTGACATTTTCAATCTCAGCC	0.552000													15	173					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21217225	21217225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21217225G>A	ENST00000380216.1	-	1	85	c.80C>T	c.(79-81)cCt>cTt	p.P27L		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	27					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GTGAGTCTGAGGCAGATCACA	0.488000													30	113					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150886928	150886928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150886928C>T	ENST00000261800.5	-	22	12316	c.12304G>A	c.(12304-12306)Gag>Aag	p.E4102K		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	4102					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTTGAGCTCGATGGCAGGC	0.567000													20	89					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100131594	100131594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100131594C>T	ENST00000394897.1	-	4	410	c.328G>A	c.(328-330)Ggc>Agc	p.G110S	RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000407820.2_5'UTR|ADH6_ENST00000237653.7_Missense_Mutation_p.G110S|ADH6_ENST00000394899.2_Missense_Mutation_p.G110S			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	110					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	CAAAAATTGCCCTCAGAATTC	0.303000													32	91					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28499611	28499611	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28499611C>T	ENST00000412168.2	+	3	387	c.298C>T	c.(298-300)Ccc>Tcc	p.P100S	GPX5_ENST00000442674.2_3'UTR|GPX5_ENST00000469384.1_Intron	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	100					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	GTTGGGCTTTCCCTGCAACCA	0.468000													63	227					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55145099	55145099	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55145099G>A	ENST00000414150.2	+	12	2491	c.2213G>A	c.(2212-2214)aGg>aAg	p.R738K	MROH7_ENST00000409996.1_Missense_Mutation_p.R306K|MROH7_ENST00000339553.5_Missense_Mutation_p.R738K|MROH7_ENST00000454855.2_Missense_Mutation_p.R256K|MROH7_ENST00000545244.1_Missense_Mutation_p.R306K|MROH7_ENST00000395690.2_Missense_Mutation_p.R738K|MROH7_ENST00000421030.2_Missense_Mutation_p.R738K					maestro heat-like repeat family member 7																		TACCGCCACAGGGCGCTGGAG	0.657000													11	40					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16060099	16060099	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16060099C>T	ENST00000322107.1	+	1	282	c.282C>T	c.(280-282)acC>acT	p.T94T		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						ATTCCATCACCTTTGTGGCTT	0.512000													97	304					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149075934	149075934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:149075934G>A	ENST00000355292.3	-	5	2507	c.2145C>T	c.(2143-2145)atC>atT	p.I715I	NR3C2_ENST00000344721.4_Silent_p.I711I|NR3C2_ENST00000342437.4_Intron|NR3C2_ENST00000503313.1_5'UTR|NR3C2_ENST00000511528.1_Silent_p.I715I|NR3C2_ENST00000512865.1_Intron|NR3C2_ENST00000358102.3_Silent_p.I711I|RP11-76G10.1_ENST00000514843.1_RNA			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	711	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TTGCAGGAGCGATGTACGTTG	0.577000													45	102					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77283313	77283313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77283313C>T	ENST00000388914.3	-	12	2138	c.1986G>A	c.(1984-1986)gtG>gtA	p.V662V		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	662										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						TACTTGTTTTCACCTCATTTA	0.418000													33	90					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61848064	61848064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61848064C>T	ENST00000280772.1	-	29	3572	c.3381G>A	c.(3379-3381)acG>acA	p.T1127T	ANK3_ENST00000355288.2_Silent_p.T261T|ANK3_ENST00000503366.1_Silent_p.T1128T|ANK3_ENST00000373827.2_Silent_p.T1121T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1127					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGAAATCTTTCGTGATAATCC	0.438000													29	98					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81654598	81654598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81654598G>A	ENST00000558726.1	-	4	492	c.357C>T	c.(355-357)atC>atT	p.I119I	TMC3_ENST00000359440.5_Silent_p.I119I			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	119						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						AGGGAATGAAGATGACCACAA	0.483000													14	18					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139940249	139940249	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139940249G>A	ENST00000357560.4	-	11	1450	c.1007C>T	c.(1006-1008)tCt>tTt	p.S336F	APBB3_ENST00000508496.2_Missense_Mutation_p.S113F|APBB3_ENST00000511201.2_Intron|APBB3_ENST00000412920.3_Missense_Mutation_p.S334F|APBB3_ENST00000354402.5_Missense_Mutation_p.S343F|APBB3_ENST00000356738.2_Missense_Mutation_p.S341F|APBB3_ENST00000358580.5_Intron	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	336	PID 2.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCATGAGAGAGTCAGACAC	0.607000													11	42					0	0	1	0	0
RBBP5	5929	broad.mit.edu	37	1	205068928	205068928	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205068928G>A	ENST00000264515.6	-	9	1060	c.919C>T	c.(919-921)Cga>Tga	p.R307*	RBBP5_ENST00000367164.1_Nonsense_Mutation_p.R307*	NM_001193273.1|NM_005057.3	NP_001180202.1|NP_005048.2	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	307					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			ATGATGGGTCGAACAGGATGC	0.363000													50	135					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70049347	70049347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70049347C>T	ENST00000370598.1	+	26	4231	c.3410C>T	c.(3409-3411)tCa>tTa	p.S1137L	BAI3_ENST00000546190.1_Missense_Mutation_p.S101L|BAI3_ENST00000238918.8_Missense_Mutation_p.S343L	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1137					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GTGTTTGATTCATTGCAAGGC	0.443000													69	118					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54971065	54971065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54971065C>T	ENST00000243052.3	+	15	2000	c.1564C>T	c.(1564-1566)Cca>Tca	p.P522S	PPP1R1A_ENST00000547431.1_3'UTR|PDE1B_ENST00000550620.1_Missense_Mutation_p.P502S|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Missense_Mutation_p.P481S	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	522					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						AGAGGCCCCCCCATCCCCTGC	0.567000													63	128					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44044528	44044528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44044528G>A	ENST00000359947.4	+	7	956	c.616G>A	c.(616-618)Gag>Aag	p.E206K	PTPRF_ENST00000372413.3_Missense_Mutation_p.E206K|PTPRF_ENST00000372414.3_Missense_Mutation_p.E206K|PTPRF_ENST00000438120.1_Missense_Mutation_p.E206K	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	206	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGCAAGTACGAGTGTGTGGC	0.602000													14	51					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166944732	166944732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:166944732C>T	ENST00000510118.1	-	5	701	c.361G>A	c.(361-363)Gcc>Acc	p.A121T	RPS6KA2_ENST00000405189.3_Missense_Mutation_p.A7T|RPS6KA2_ENST00000481261.2_Missense_Mutation_p.A7T|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.A96T|RPS6KA2_ENST00000366863.2_5'UTR|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.A104T			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	96	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TTTAGGGTGGCTTTCTTAAGG	0.478000													37	93					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804617	115804617	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115804617C>T	ENST00000369295.2	+	1	812	c.726C>T	c.(724-726)ttC>ttT	p.F242F		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	242					positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	TCATGGCCTTCGTGTACCTGC	0.657000													5	51					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77619947	77619947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77619947C>T	ENST00000521891.2	+	3	3205	c.2757C>T	c.(2755-2757)gcC>gcT	p.A919A	ZFHX4_ENST00000455469.2_Silent_p.A893A|ZFHX4_ENST00000050961.6_Silent_p.A893A|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Silent_p.A893A	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	893						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTGGAGGCCCTAAGTGTGC	0.507000										HNSCC(33;0.089)			6	40					0	0	1	0	0
PTCD1	26024	broad.mit.edu	37	7	99021527	99021527	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99021527G>A	ENST00000292478.4	-	7	2041	c.1791C>T	c.(1789-1791)gcC>gcT	p.A597A	ATP5J2-PTCD1_ENST00000413834.1_Silent_p.A646A|PTCD1_ENST00000555673.1_Silent_p.A646A	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1									p.A597A(1)		endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GCTTCCTGATGGCCGCGTTGA	0.527000													6	80					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159654305	159654305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159654305C>T	ENST00000297267.9	+	11	2961	c.2761C>T	c.(2761-2763)Cgg>Tgg	p.R921W	FNDC1_ENST00000340366.6_Missense_Mutation_p.R858W	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	921						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CAGCCTGCATCGGAAGGAACC	0.602000													8	28					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703277	4703277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4703277C>T	ENST00000396950.3	-	2	904	c.665G>A	c.(664-666)cGa>cAa	p.R222Q		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAGAACCGTTCGTATTATCAG	0.488000													29	59					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56300731	56300731	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56300731G>A	ENST00000443188.1	-	10	3258	c.2548C>T	c.(2548-2550)Caa>Taa	p.Q850*	NLRP11_ENST00000589093.1_Nonsense_Mutation_p.Q850*|NLRP11_ENST00000592953.1_Nonsense_Mutation_p.Q751*|NLRP11_ENST00000360133.3_Nonsense_Mutation_p.Q796*|NLRP11_ENST00000589824.2_Nonsense_Mutation_p.Q796*	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	850							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GCAATATATTGACAGATATCG	0.418000													38	143					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561350	9561350	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9561350T>A	ENST00000378429.3	-	5	978	c.432A>T	c.(430-432)gaA>gaT	p.E144D	PAK7_ENST00000378423.1_Missense_Mutation_p.E144D|PAK7_ENST00000353224.5_Missense_Mutation_p.E144D	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	144	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CCCTGTACTTTTCGGTCGTGT	0.512000													80	153					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21419872	21419872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21419872G>A	ENST00000313654.9	+	27	3556	c.3315G>A	c.(3313-3315)ggG>ggA	p.G1105G	LAMA3_ENST00000399516.3_Silent_p.G1105G	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1105	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCTTCCTGGGGTCACCTTGA	0.488000													29	68					0	0	1	0	0
QPRT	23475	broad.mit.edu	37	16	29706093	29706093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29706093C>T	ENST00000395384.4	+	2	283	c.122C>T	c.(121-123)cCc>cTc	p.P41L	AC009133.19_ENST00000449759.1_Missense_Mutation_p.80_80insS|QPRT_ENST00000219771.7_Intron|QPRT_ENST00000562473.1_Intron	NM_014298.3	NP_055113.2	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	41					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9					Niacin(DB00627)	GGGGCAGGCCCCTCGCAGGCG	0.652000													19	73					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44986361	44986361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44986361G>A	ENST00000372227.1	-	3	712	c.172C>T	c.(172-174)Ctc>Ttc	p.L58F	SLC35C2_ENST00000543605.1_Missense_Mutation_p.L87F|SLC35C2_ENST00000317734.8_Missense_Mutation_p.L58F|SLC35C2_ENST00000372230.5_Missense_Mutation_p.L58F|SLC35C2_ENST00000372229.1_Intron|SLC35C2_ENST00000243896.2_Missense_Mutation_p.L58F			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	58					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				GCGGAGAAGAGGAAGATCACG	0.617000													18	58					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87373167	87373167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87373167C>T	ENST00000327946.7	-	15	2683	c.2598G>A	c.(2596-2598)aaG>aaA	p.K866K	GRID1_ENST00000536331.1_Silent_p.K437K	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	866						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TGCTGACCTCCTTGGGGGTCT	0.612000										Multiple Myeloma(13;0.14)			9	23					0	0	1	0	0
TRBV19	28568	broad.mit.edu	37	7	142326879	142326879	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142326879G>A	ENST00000390393.3	+	0	385																											AGGACCCAGGGCAAGGGCTGA	0.473000													44	136					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155161724	155161724	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155161724C>T	ENST00000357232.3	-	23	5958	c.5959G>A	c.(5959-5961)Gat>Aat	p.D1987N		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1987	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGTGGATTATCATTGACATCC	0.393000													20	45					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50719833	50719833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50719833G>A	ENST00000449103.1	-	22	3758	c.3618C>T	c.(3616-3618)atC>atT	p.I1206I	PLXNB2_ENST00000359337.4_Silent_p.I1206I			O15031	PLXB2_HUMAN	plexin B2	1206					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCATGGGCACGATGACCAGCG	0.677000													6	19					0	0	1	0	0
DOLK	22845	broad.mit.edu	37	9	131708608	131708608	+	Silent	SNP	G	G	A	rs149462670		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131708608G>A	ENST00000372586.3	-	1	1290	c.975C>T	c.(973-975)tcC>tcT	p.S325S	RP11-101E3.5_ENST00000482796.1_Intron	NM_014908.3	NP_055723.1	Q9UPQ8	DOLK_HUMAN	dolichol kinase	325					dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity			breast(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	11						TCTTGGACTCGGAAGATGACC	0.572000													66	150					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134617989	134617989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:134617989C>T	ENST00000361388.2	+	5	935	c.469C>T	c.(469-471)Caa>Taa	p.Q157*	CALD1_ENST00000361675.2_Nonsense_Mutation_p.Q157*|CALD1_ENST00000422748.1_Nonsense_Mutation_p.Q157*|CALD1_ENST00000543443.1_Nonsense_Mutation_p.Q162*|CALD1_ENST00000393118.2_Nonsense_Mutation_p.Q151*|CALD1_ENST00000424922.1_Nonsense_Mutation_p.Q151*|CALD1_ENST00000495522.1_Nonsense_Mutation_p.Q151*|CALD1_ENST00000417172.1_Nonsense_Mutation_p.Q157*|CALD1_ENST00000361901.2_Nonsense_Mutation_p.Q157*	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	370	Myosin and calmodulin-binding (By similarity).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						TGAAAGTCGCCAAGAAAGATA	0.403000													9	20					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847869	123847869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123847869G>A	ENST00000531945.1	-	1	619	c.530C>T	c.(529-531)aCc>aTc	p.T177I		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CAGGCGGAAGGTGAGGGAGGT	0.557000													8	67					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41450887	41450887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41450887C>T	ENST00000400454.1	-	26	4915	c.4438G>A	c.(4438-4440)Gag>Aag	p.E1480K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1480	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGCTCCTGCTCCTTTGAGAAC	0.572000													6	29					0	0	1	0	0
GP6	51206	broad.mit.edu	37	19	55525594	55525594	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55525594C>T	ENST00000310373.3	-	8	1746	c.1719G>A	c.(1717-1719)agG>agA	p.R573R	GP6_ENST00000417454.1_3'UTR|CTC-550B14.7_ENST00000586845.1_RNA|CTC-550B14.7_ENST00000593060.1_RNA|GP6_ENST00000333884.2_3'UTR	NM_001083899.1	NP_001077368.1	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	0					enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		acctcagccccctgagttgct	0.522000													4	12					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41476499	41476499	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41476499G>A	ENST00000314992.5	-	10	1365	c.1175C>T	c.(1174-1176)cCt>cTt	p.P392L	EXD1_ENST00000458580.2_Missense_Mutation_p.P450L	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	392					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						TAGATGTTGAGGATTTGTAGC	0.393000													19	205					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130162359	130162359	+	Missense_Mutation	SNP	C	C	T	rs150604117	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130162359C>T	ENST00000265379.6	+	36	7021	c.6527C>T	c.(6526-6528)gCc>gTc	p.A2176V	COL6A5_ENST00000432398.2_Missense_Mutation_p.A2176V			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2176	Nonhelical region.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						CTTGAGGATGCCTGTAGACTC	0.368000													18	55					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092811	151092811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151092811G>A	ENST00000370340.3	+	3	942	c.675G>A	c.(673-675)gaG>gaA	p.E225E	MAGEA4_ENST00000393920.1_Silent_p.E225E|MAGEA4_ENST00000393921.1_Silent_p.E225E|MAGEA4_ENST00000370337.4_Silent_p.E225E|MAGEA4_ENST00000276344.2_Silent_p.E225E|MAGEA4_ENST00000360243.2_Silent_p.E225E|MAGEA4_ENST00000370335.1_Silent_p.E225E			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	225	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCTGGGAGGAGCTGGGTGTGA	0.537000													56	53					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141408672	141408672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141408672C>T	ENST00000397541.2	+	1	520	c.114C>T	c.(112-114)agC>agT	p.S38S	WEE2-AS1_ENST00000488785.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	38					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					AGGCTTCGAGCCAAACCCCAG	0.468000													58	198					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77662359	77662359	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77662359G>A	ENST00000296043.6	+	5	3986	c.3033G>A	c.(3031-3033)ctG>ctA	p.L1011L		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1011	ASD1.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GCCGGCGCCTGACTCCCGAGC	0.726000													6	16					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188202397	188202397	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:188202397C>T	ENST00000312675.4	+	4	457	c.211C>T	c.(211-213)Cca>Tca	p.P71S	LPP_ENST00000448637.1_Missense_Mutation_p.P71S|LPP_ENST00000543006.1_Missense_Mutation_p.P71S	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	71	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TCTTCCACCCCCACCTCCACC	0.413000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								51	157					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51960961	51960961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51960961C>T	ENST00000321424.3	-	2	553	c.487G>A	c.(487-489)Ggg>Agg	p.G163R	SIGLEC8_ENST00000340550.5_Intron|SIGLEC8_ENST00000430817.1_Intron	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	163	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TCTAGGGTCCCTAGGATGAGG	0.602000													29	71					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14339441	14339441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:14339441C>T	ENST00000571589.1	+	11	1308	c.1136C>T	c.(1135-1137)cCt>cTt	p.P379L	MKL2_ENST00000574045.1_Missense_Mutation_p.P379L|MKL2_ENST00000318282.5_Missense_Mutation_p.P379L|MKL2_ENST00000341243.5_Missense_Mutation_p.P368L	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	368					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AATGCCACACCTAACACACCA	0.378000													30	118					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110740790	110740790	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110740790C>T	ENST00000331565.4	+	12	2393	c.1908C>T	c.(1906-1908)ttC>ttT	p.F636F		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	636					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CTGTGGTGTTCGTCCTGCGGC	0.607000													12	30					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132160519	132160519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:132160519C>T	ENST00000511190.1	-	6	2199	c.1730G>A	c.(1729-1731)cGa>cAa	p.R577Q	USP26_ENST00000370832.1_Missense_Mutation_p.R577Q|USP26_ENST00000406273.1_Missense_Mutation_p.R577Q	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	577					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					AGTCATCTTTCGAATAACTTT	0.398000													38	22					0	0	1	0	0
HRASLS2	54979	broad.mit.edu	37	11	63325900	63325900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63325900C>T	ENST00000255695.1	-	3	409	c.351G>A	c.(349-351)gtG>gtA	p.V117V		NM_017878.1	NP_060348.1	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	117					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6						GCAGATGGTTCACGAAGTGCT	0.597000													23	61					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149477052	149477052	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149477052C>T	ENST00000378016.2	+	0	1229							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGCAGGTTTCCCCTGCTGAG	0.582000													11	8					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587558	55587558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55587558C>T	ENST00000333976.4	+	1	473	c.453C>T	c.(451-453)gcC>gcT	p.A151A		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				GATCCTATGCCTGGGGAGTCT	0.478000													25	165					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233925273	233925273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233925273C>T	ENST00000359570.5	+	1	85	c.85C>T	c.(85-87)Ctc>Ttc	p.L29F	INPP5D_ENST00000538935.1_Missense_Mutation_p.L29F			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	29	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CGGGAGCTTCCTCGTGCGTGC	0.642000													12	32					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62041900	62041900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62041900C>T	ENST00000578147.1	-	9	1456	c.1380G>A	c.(1378-1380)gaG>gaA	p.E460E	SCN4A_ENST00000435607.1_Silent_p.E460E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	460					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TCTCCTTATCCTCGGCCAGGG	0.532000													13	41					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151773863	151773863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:151773863G>A	ENST00000535741.1	-	23	3472	c.2999C>T	c.(2998-3000)tCa>tTa	p.S1000L	LRBA_ENST00000510413.1_Missense_Mutation_p.S1000L|LRBA_ENST00000507224.1_Missense_Mutation_p.S1000L|LRBA_ENST00000357115.3_Missense_Mutation_p.S1000L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1000						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AGATTCTAGTGAACTTGTCTT	0.378000													22	76					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43625229	43625229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:43625229G>A	ENST00000332857.6	-	4	3486	c.3458C>T	c.(3457-3459)cCt>cTt	p.P1153L		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		TACTGAAGGAGGCTGTTTCTT	0.453000													13	114					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148916196	148916196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:148916196C>T	ENST00000264613.6	-	9	1933	c.1671G>A	c.(1669-1671)atG>atA	p.M557I	CP_ENST00000462336.1_5'UTR	NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	557	F5/8 type A 2.|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TGCATATTTTCATTGGCCCAA	0.378000													31	77					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152329710	152329710	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152329710G>A	ENST00000388718.5	-	3	624	c.552C>T	c.(550-552)tcC>tcT	p.S184S	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	184	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCACAGCTGGACCTGTGGT	0.468000													68	154					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086942	100086942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100086942C>T	ENST00000423930.1	+	4	1757	c.1598C>T	c.(1597-1599)tCc>tTc	p.S533F	NYAP1_ENST00000454988.1_Missense_Mutation_p.S476F|NYAP1_ENST00000300179.2_Missense_Mutation_p.S533F			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	533																	TGCCTGGCCTCCCCCCACAGC	0.697000													8	8					0	0	1	0	0
ACR	49	broad.mit.edu	37	22	51177731	51177731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:51177731C>T	ENST00000216139.5	+	2	150	c.110C>T	c.(109-111)cCa>cTa	p.P37L	ACR_ENST00000529621.1_Missense_Mutation_p.P37L	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	37					acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		AGGCAAAACCCACAGGGTGGT	0.597000													4	17					0	0	1	0	0
PSMG2	56984	broad.mit.edu	37	18	12706668	12706668	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:12706668T>G	ENST00000317615.6	+	2	859	c.177T>G	c.(175-177)aaT>aaG	p.N59K	RP11-973H7.2_ENST00000585331.1_RNA|PSMG2_ENST00000590217.1_Missense_Mutation_p.N59K	NM_020232.4|NM_147163.1	NP_064617.2|NP_671692.1	Q969U7	PSMG2_HUMAN	proteasome (prosome, macropain) assembly chaperone 2	59					proteasome assembly	nucleus	protein binding			lung(1)|prostate(2)|skin(1)	4						TTGGAAACAATCCATATGCGA	0.368000													14	98					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5758568	5758568	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5758568G>A	ENST00000317121.3	+	1	888	c.822G>A	c.(820-822)gaG>gaA	p.E274E	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	274					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		ATCTGACAGAGATGAAGGCTA	0.433000													83	348					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120241121	120241121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120241121G>A	ENST00000392521.2	-	10	1239	c.1184C>T	c.(1183-1185)tCg>tTg	p.S395L	CIT_ENST00000261833.7_Missense_Mutation_p.S395L	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	395	AGC-kinase C-terminal.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGAAACCCACGAATTCTTCTC	0.522000													42	98					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51165482	51165482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51165482G>A	ENST00000293441.1	-	23	6244	c.6226C>T	c.(6226-6228)Ctc>Ttc	p.L2076F	SHANK1_ENST00000359082.3_Missense_Mutation_p.L2067F|SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000391813.1_Missense_Mutation_p.L1463F|SHANK1_ENST00000391814.1_Missense_Mutation_p.L2084F	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2076					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GTCGGTGAGAGGGAGCGCGAG	0.682000													6	42					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82578963	82578963	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82578963G>A	ENST00000423517.2	-	6	11278	c.10941C>T	c.(10939-10941)ctC>ctT	p.L3647L	PCLO_ENST00000437081.1_Silent_p.L367L|PCLO_ENST00000333891.8_Silent_p.L3647L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3578					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TATCATCAGGGAGGGGTTTTT	0.473000													59	182					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3228264	3228264	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3228264G>A	ENST00000217939.6	-	7	8134	c.7980C>T	c.(7978-7980)acC>acT	p.T2660T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2660	Ig-like C2-type 11.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCCCGGGAGGGGTGCAGGGGA	0.592000													38	31					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744773	140744773	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140744773C>T	ENST00000518069.1	+	1	876	c.876C>T	c.(874-876)ttC>ttT	p.F292F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGAGACTTTCCAACTTGATT	0.463000													12	36					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193002904	193002904	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:193002904C>T	ENST00000342358.4	-	27	3142	c.3023_splice	c.e27-1	p.E1009_splice	ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1009					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AGAAAACACTCACTACAAAAG	0.318000													15	54					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73721613	73721613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:73721613G>A	ENST00000427855.1	+	14	1616	c.1514G>A	c.(1513-1515)cGg>cAg	p.R505Q	PAPLN_ENST00000340738.5_Missense_Mutation_p.R478Q|PAPLN_ENST00000381166.3_Missense_Mutation_p.R505Q|PAPLN_ENST00000554301.1_Missense_Mutation_p.R505Q|PAPLN_ENST00000555445.1_Missense_Mutation_p.R505Q			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	505	TSP type-1 5.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding	p.R478Q(1)|p.R505Q(1)		NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		TCGGGCACTCGGAGGCGACAG	0.657000													11	46					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11060364	11060364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11060364C>T	ENST00000287766.4	+	5	872	c.451C>T	c.(451-453)Ctg>Ttg	p.L151L	SLC6A1_ENST00000536032.1_5'UTR|SLC6A1-AS1_ENST00000414969.2_RNA	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	151					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CATTTACTACCTGTACAACTC	0.582000													13	36					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242383365	242383365	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:242383365C>T	ENST00000442594.2	-	6	893	c.384G>A	c.(382-384)caG>caA	p.Q128Q	PLD5_ENST00000427495.1_Silent_p.Q158Q|PLD5_ENST00000536534.1_Silent_p.Q220Q	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	220						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AGAAGGAGGACTGCAGCCGGC	0.547000													16	55					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100155362	100155362	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100155362C>T	ENST00000263174.4	+	7	1921	c.1546C>T	c.(1546-1548)Cct>Tct	p.P516S	PALMD_ENST00000605497.1_Missense_Mutation_p.P516S	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	516					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CTTAGGCAGCCCTGTCCACCA	0.428000													25	68					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16033188	16033188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16033188G>A	ENST00000326742.7	-	7	972	c.971C>T	c.(970-972)aCc>aTc	p.T324I	CYP4F11_ENST00000402119.3_Missense_Mutation_p.T324I|CYP4F11_ENST00000248041.7_Missense_Mutation_p.T324I			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	324					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						AAACATGAAGGTGTCAGCTTC	0.527000													59	163					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753258	76753258	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76753258C>T	ENST00000536229.3	+	1	1577	c.868C>T	c.(868-870)Cgc>Tgc	p.R290C	SALL3_ENST00000575389.2_Missense_Mutation_p.R423C|SALL3_ENST00000537592.2_Missense_Mutation_p.R423C			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCACAAATGCCGCTTCTGCGC	0.642000													8	15					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50658827	50658827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50658827G>A	ENST00000439308.2	-	16	4453	c.3961C>T	c.(3961-3963)Ctg>Ttg	p.L1321L	TUBGCP6_ENST00000248846.5_Silent_p.L1321L|TUBGCP6_ENST00000491449.1_5'UTR	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1321					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCTACAGGCAGCCGTGGCCCA	0.682000													11	33					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649546	75649546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:75649546C>T	ENST00000361470.2	+	1	1501	c.1223C>T	c.(1222-1224)cCt>cTt	p.P408L		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	408	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CTGCCTAACCCTGGTGAGGGC	0.627000													4	16					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78056580	78056580	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:78056580G>A	ENST00000299642.4	+	1	169	c.84G>A	c.(82-84)caG>caA	p.Q28Q	CLEC3A_ENST00000575655.1_Silent_p.Q19Q|RP11-281J9.2_ENST00000563114.1_RNA	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	19					skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						TCCTGGACCAGACCACCAGCC	0.507000													5	56					0	0	1	0	0
SFXN2	118980	broad.mit.edu	37	10	104488271	104488271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104488271C>T	ENST00000369893.4	+	4	583	c.416C>T	c.(415-417)tCc>tTc	p.S139F		NM_178858.4	NP_849189.1	Q96NB2	SFXN2_HUMAN	sideroflexin 2	139					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|prostate(1)	13		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		AATGCGGCTTCCCCCACATCA	0.567000													37	72					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27448833	27448833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27448833G>A	ENST00000337929.3	+	4	650	c.177G>A	c.(175-177)aaG>aaA	p.K59K	IL21R_ENST00000564089.1_Silent_p.K59K|IL21R_ENST00000395755.1_Silent_p.K59K|IL21R_ENST00000395754.4_Silent_p.K59K	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	59					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						AAGAGCTGAAGGACGAGGCCA	0.612000			T	BCL6	NHL								20	55					0	0	1	0	0
NSUN7	79730	broad.mit.edu	37	4	40778245	40778245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40778245G>A	ENST00000381782.2	+	7	1500	c.1005G>A	c.(1003-1005)ttG>ttA	p.L335L	NSUN7_ENST00000316607.5_Silent_p.L335L	NM_024677.4	NP_078953.3			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						ATCCTGACTTGAAGACCCTTT	0.308000													28	92					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117188502	117188502	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117188502C>T	ENST00000362057.3	-	4	1323	c.1155G>A	c.(1153-1155)gcG>gcA	p.A385A	DFNB31_ENST00000265134.6_Silent_p.A2A	NM_001173425.1|NM_015404.3	NP_001166896.1|NP_056219.3	Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	385					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTGCCGAGTTCGCCATGGTCT	0.632000													15	22					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6058963	6058963	+	Missense_Mutation	SNP	G	G	A	rs62643643		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6058963G>A	ENST00000261405.5	-	51	8496	c.8242C>T	c.(8242-8244)Cac>Tac	p.H2748Y		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2748	CTCK.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding	p.H2748N(1)		NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TGGCAGTAGTGGATATCCACC	0.522000													25	90					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205197795	205197795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205197795C>T	ENST00000358024.3	+	1	492	c.103C>T	c.(103-105)Cct>Tct	p.P35S		NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	35						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGACCTCCGGCCTGGGGAGAC	0.677000													17	27					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35829246	35829246	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35829246C>T	ENST00000085219.5	+	6	1227	c.1161C>T	c.(1159-1161)ctC>ctT	p.L387L	CD22_ENST00000536635.2_Intron|CD22_ENST00000270311.6_Silent_p.L267L|CD22_ENST00000544992.2_Silent_p.L387L|CD22_ENST00000594250.1_Intron|CD22_ENST00000419549.2_Silent_p.L215L|CD22_ENST00000341773.6_Intron	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	387	Ig-like C2-type 3.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CAAAGATCCTCCCCTGGCACG	0.527000													29	80					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124594553	124594553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124594553C>T	ENST00000368904.1	-	9	2000	c.1051G>A	c.(1051-1053)Gaa>Aaa	p.E351K	CUZD1_ENST00000392790.1_Missense_Mutation_p.E351K|CUZD1_ENST00000545804.1_Missense_Mutation_p.E351K			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	351	ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GTGATCACTTCAGAAGTTGAG	0.338000													30	74					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32505269	32505269	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:32505269C>T	ENST00000520502.2	+	1	33	c.33C>T	c.(31-33)gtC>gtT	p.V11V	NRG1_ENST00000287840.5_Intron|NRG1_ENST00000520407.1_Intron|NRG1_ENST00000405005.2_Intron|NRG1_ENST00000341377.5_Intron|NRG1_ENST00000287845.5_Intron|NRG1_ENST00000287842.3_Intron|NRG1_ENST00000338921.4_Intron|NRG1_ENST00000523079.1_Intron|NRG1_ENST00000356819.4_Intron|NRG1_ENST00000521670.1_Intron|NRG1_ENST00000519301.1_Intron	NM_013959.3	NP_039253.1	Q02297	NRG1_HUMAN	neuregulin 1	0					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGTCTGAGGTCGCCGCCGAGA	0.612000													8	57					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74630995	74630995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74630995G>A	ENST00000358632.4	-	8	1572	c.877C>T	c.(877-879)Cgg>Tgg	p.R293W	CYP11A1_ENST00000419019.2_Missense_Mutation_p.R293W|CYP11A1_ENST00000268053.6_Missense_Mutation_p.R451W	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	451					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CCCAAGTTCCGGAAGTAGGTG	0.557000													85	102					0	0	1	0	0
F11R	50848	broad.mit.edu	37	1	160970835	160970835	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160970835G>A	ENST00000368026.6	-	3	490	c.216C>T	c.(214-216)ctC>ctT	p.L72L	F11R_ENST00000289779.3_3'UTR|F11R_ENST00000537746.1_Silent_p.L72L|F11R_ENST00000472573.1_5'UTR	NM_016946.4	NP_058642.1	Q9Y624	JAM1_HUMAN	F11 receptor	72	Ig-like V-type 1.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)	12	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			TATAGCAAACGAGTCTGGTGG	0.493000													22	41					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215820886	215820886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215820886G>A	ENST00000366943.2	-	67	15155	c.14769C>T	c.(14767-14769)atC>atT	p.I4923I	USH2A_ENST00000307340.3_Silent_p.I4923I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4923	Fibronectin type-III 34.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTGAAACTGATCCACTCGG	0.532000										HNSCC(13;0.011)			24	42					0	0	1	0	0
MVD	4597	broad.mit.edu	37	16	88723893	88723893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:88723893G>A	ENST00000301012.3	-	4	383	c.354C>T	c.(352-354)ttC>ttT	p.F118F	MVD_ENST00000568709.1_5'UTR	NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	118					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CAGCCGTGGGGAAGTTGTTCA	0.701000													6	13					0	0	1	0	0
C22orf43	51233	broad.mit.edu	37	22	23956368	23956368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23956368G>A	ENST00000317749.5	-	9	872	c.575C>T	c.(574-576)tCa>tTa	p.S192L		NM_016449.3	NP_057533.2	Q6PGQ1	CV043_HUMAN	chromosome 22 open reading frame 43	192	Asp-rich.									endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						GTGTCTCAGTGAGCATCTTAA	0.443000													17	110					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61761051	61761051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:61761051C>T	ENST00000577390.1	-	9	2437	c.1483G>A	c.(1483-1485)Gaa>Aaa	p.E495K	CDH8_ENST00000577730.1_Missense_Mutation_p.E495K|CDH8_ENST00000299345.6_Missense_Mutation_p.E495K|CDH8_ENST00000584337.1_Missense_Mutation_p.E495K	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	495	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GATGCGAATTCAGGGGCGTTG	0.393000													60	137					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46888191	46888191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46888191C>T	ENST00000359759.4	+	2	1408	c.1387C>T	c.(1387-1389)Ctt>Ttt	p.L463F	COL18A1_ENST00000355480.5_Missense_Mutation_p.L228F|COL18A1_ENST00000400337.2_Missense_Mutation_p.L48F			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	463	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GCTGCAGCTCCTTGGGGACCC	0.672000													28	71					0	0	1	0	0
OR52A1	23538	broad.mit.edu	37	11	5173285	5173285	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5173285G>A	ENST00000380367.1	-	2	732	c.315C>T	c.(313-315)ttC>ttT	p.F105F	OR52A1_ENST00000328942.1_Silent_p.F105F			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	105					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGTGTGGATGAACCACATTT	0.443000													11	26					0	0	1	0	0
METTL22	79091	broad.mit.edu	37	16	8738571	8738571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:8738571C>T	ENST00000381920.3	+	10	1426	c.1168C>T	c.(1168-1170)Ctc>Ttc	p.L390F	METTL22_ENST00000561758.1_Missense_Mutation_p.L334F|METTL22_ENST00000568967.1_3'UTR	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	390							methyltransferase activity			large_intestine(5)|lung(4)	9						TTACGAGCGCCTCCAGCAACT	0.632000													11	33					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047963	9047963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9047963G>A	ENST00000397910.4	-	5	33871	c.33668C>T	c.(33667-33669)tCa>tTa	p.S11223L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11225	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTTAGATTTGAAAACGCACT	0.478000													14	27					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101336183	101336183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101336183G>A	ENST00000392979.3	+	4	582	c.221G>A	c.(220-222)gGa>gAa	p.G74E	ANO4_ENST00000392977.3_Missense_Mutation_p.G109E|ANO4_ENST00000538618.1_Missense_Mutation_p.G275E|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	109						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						AAATCAAATGGACTTTACTTT	0.368000										HNSCC(74;0.22)			24	105					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922608	37922608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37922608G>A	ENST00000346872.3	-	8	1026	c.965C>T	c.(964-966)cCc>cTc	p.P322L	IKZF3_ENST00000439167.2_Missense_Mutation_p.P249L|IKZF3_ENST00000350532.3_Missense_Mutation_p.P283L|IKZF3_ENST00000583368.1_Missense_Mutation_p.P75L|IKZF3_ENST00000377958.2_Missense_Mutation_p.P235L|IKZF3_ENST00000467757.1_Missense_Mutation_p.P266L|IKZF3_ENST00000351680.3_Missense_Mutation_p.P283L|IKZF3_ENST00000377952.2_Missense_Mutation_p.P101L|IKZF3_ENST00000346243.3_Missense_Mutation_p.P244L|IKZF3_ENST00000377944.3_Missense_Mutation_p.P179L|IKZF3_ENST00000535189.1_Missense_Mutation_p.P288L|IKZF3_ENST00000394189.2_Missense_Mutation_p.P140L|IKZF3_ENST00000439016.2_Missense_Mutation_p.P227L|IKZF3_ENST00000377945.3_Missense_Mutation_p.P188L	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	322					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTGGACCAAGGGGCGCAGGGC	0.557000													31	39					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123279501	123279501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123279501C>T	ENST00000358487.5	-	7	1203	c.931G>A	c.(931-933)Gtt>Att	p.V311I	FGFR2_ENST00000360144.3_Missense_Mutation_p.V222I|FGFR2_ENST00000478859.1_Missense_Mutation_p.V83I|FGFR2_ENST00000369059.1_Missense_Mutation_p.V196I|FGFR2_ENST00000351936.6_Missense_Mutation_p.V311I|FGFR2_ENST00000357555.5_Missense_Mutation_p.V222I|FGFR2_ENST00000369060.4_Missense_Mutation_p.V311I|FGFR2_ENST00000346997.2_Missense_Mutation_p.V311I|FGFR2_ENST00000356226.4_Missense_Mutation_p.V196I|FGFR2_ENST00000457416.2_Missense_Mutation_p.V311I|FGFR2_ENST00000369061.4_Intron|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000369056.1_Missense_Mutation_p.V311I	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	311	Ig-like C2-type 3.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	ACCTTGAGAACCTTGAGGTAG	0.522000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				29	60					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060232	54060232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54060232C>T	ENST00000312233.2	-	3	910	c.344G>A	c.(343-345)gGc>gAc	p.G115D		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	115					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						CTTGGAAGGGCCCCCCAGATC	0.647000													10	51					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38192815	38192815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38192815G>A	ENST00000373048.4	-	8	1730	c.1731C>T	c.(1729-1731)ctC>ctT	p.L577L	EPHA10_ENST00000540011.1_Silent_p.L72L|EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000330210.7_Silent_p.L72L|EPHA10_ENST00000427468.2_Silent_p.L577L	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	577						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGCCCAGGACGAGGAGGGCCG	0.617000													25	42					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10782145	10782145	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10782145G>A	ENST00000416569.2	-	2	986	c.961_splice	c.e2+1	p.P320_splice	XKR6_ENST00000304437.2_Splice_Site_p.P41_splice	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	320						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		ggcACTCACAGGGCAGGGTCT	0.692000													9	67					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167666689	167666689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167666689G>A	ENST00000367854.3	+	6	1159	c.828G>A	c.(826-828)ccG>ccA	p.P276P	RCSD1_ENST00000537350.1_Silent_p.P246P	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	276	RCSD.									NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					GCCAGCACCCGGCCCAAGAGG	0.632000													5	13					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739306	55739306	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55739306G>A	ENST00000370830.3	-	1	1056	c.358C>T	c.(358-360)Ccc>Tcc	p.P120S	BMP5_ENST00000446683.2_Missense_Mutation_p.P120S	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	120					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TACCCATTGGGAGAGGCTGGG	0.517000													42	106					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45810908	45810908	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45810908G>A	ENST00000397928.1	+	10	1885	c.1440_splice	c.e10+1	p.K480_splice	TRPM2_ENST00000300481.9_Splice_Site_p.K480_splice|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Splice_Site_p.K480_splice|TRPM2_ENST00000397932.2_Splice_Site_p.K480_splice	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	480						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GGCAGTGGAAGGTAAGTCTTC	0.577000													21	64					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48628970	48628970	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48628970C>G	ENST00000328333.8	-	12	1670	c.1563G>C	c.(1561-1563)ggG>ggC	p.G521G	COL7A1_ENST00000454817.1_Silent_p.G521G	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	521	Fibronectin type-III 4.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCACCCGCTGCCCGGGCAGCT	0.662000													16	120					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5434069	5434069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:5434069G>A	ENST00000341928.2	-	7	997	c.657C>T	c.(655-657)ccC>ccT	p.P219P	EPB41L3_ENST00000540638.2_Silent_p.P219P|EPB41L3_ENST00000342933.3_Silent_p.P219P|EPB41L3_ENST00000544123.1_Silent_p.P219P|EPB41L3_ENST00000400111.3_Silent_p.P219P|EPB41L3_ENST00000542652.2_5'UTR	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	219	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						CAAAGGAGCAGGGCAGCCTTC	0.527000													23	94					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52853451	52853451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52853451G>A	ENST00000266041.4	-	17	2131	c.2035C>T	c.(2035-2037)Cct>Tct	p.P679S	ITIH4_ENST00000485816.1_Missense_Mutation_p.P684S|ITIH4_ENST00000406595.1_Missense_Mutation_p.P649S|ITIH4_ENST00000346281.5_Missense_Mutation_p.P649S|ITIH4_ENST00000434759.3_3'UTR	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	679					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GCATGGTCAGGAACATCAGGA	0.602000													27	87					0	0	1	0	0
TRIM69	140691	broad.mit.edu	37	15	45050878	45050878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45050878C>T	ENST00000558173.1	+	2	4772	c.27C>T	c.(25-27)ttC>ttT	p.F9F	TRIM69_ENST00000329464.4_Silent_p.F213F|TRIM69_ENST00000561043.1_Intron|TRIM69_ENST00000559390.1_Silent_p.F213F|TRIM69_ENST00000338264.4_Silent_p.F54F|TRIM69_ENST00000558329.1_Silent_p.F9F|TRIM69_ENST00000560442.1_Silent_p.F9F			Q86WT6	TRI69_HUMAN	tripartite motif containing 69	213	Necessary for nuclear localization (By similarity).				apoptosis	nuclear speck	zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(9)|skin(1)	20		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		TGCATCAGTTCCTGCACAGCA	0.458000													20	51					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54307795	54307795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54307795G>A	ENST00000545554.1	+	1	2695	c.2695G>A	c.(2695-2697)Gat>Aat	p.D899N	UNC13C_ENST00000537900.1_Missense_Mutation_p.D899N|UNC13C_ENST00000260323.11_Missense_Mutation_p.D899N			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	899					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TACTGAAACAGATGAACAAAT	0.378000													31	100					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800866	185800866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185800866G>A	ENST00000302277.6	+	4	1337	c.743G>A	c.(742-744)aGa>aAa	p.R248K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	248						intracellular	zinc ion binding	p.R248I(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GGATTTAGCAGAAAAAGTAGA	0.428000													45	138					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101684039	101684039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101684039C>T	ENST00000261637.4	+	7	896	c.722C>T	c.(721-723)tCc>tTc	p.S241F		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	241					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						ATGTTTCACTCCTGTACAGGC	0.393000													10	40					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50099865	50099865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50099865C>T	ENST00000418929.2	+	4	2285	c.2273C>T	c.(2272-2274)gCc>gTc	p.A758V		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	466							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GAGCTGGGGGCCTTCTTGCAA	0.687000													9	19					0	0	1	0	0
WDPCP	51057	broad.mit.edu	37	2	63631777	63631777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:63631777G>A	ENST00000409120.1	-	4	3815	c.265C>T	c.(265-267)Cgc>Tgc	p.R89C	WDPCP_ENST00000409562.3_Missense_Mutation_p.R281C|WDPCP_ENST00000409835.1_5'UTR|WDPCP_ENST00000398544.3_Missense_Mutation_p.R122C|WDPCP_ENST00000409199.1_Missense_Mutation_p.R89C|WDPCP_ENST00000272321.7_Missense_Mutation_p.R281C			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	281					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						CATTCTGTGCGGACAGAACTC	0.433000													43	83					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813462	106813462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106813462C>T	ENST00000407775.2	+	8	1402	c.1152C>T	c.(1150-1152)ctC>ctT	p.L384L	ZFPM2_ENST00000520492.1_Silent_p.L252L|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Silent_p.L115L|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Silent_p.L252L|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	384					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ACCAGGAGCTCCATGTCCCTA	0.507000													25	141					0	0	1	0	0
AMTN	401138	broad.mit.edu	37	4	71396858	71396858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71396858C>T	ENST00000339336.4	+	8	590	c.460C>T	c.(460-462)Cca>Tca	p.P154S	AMTN_ENST00000504451.1_Missense_Mutation_p.P153S	NM_212557.2	NP_997722.1	Q6UX39	AMTN_HUMAN	amelotin	154					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				NS(3)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)|skin(1)	19			Lung(101;0.235)			TGGAAGCCTTCCAGCAGGAGG	0.592000													22	43					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932503	83932503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83932503C>T	ENST00000345382.2	-	4	1585	c.1500G>A	c.(1498-1500)gaG>gaA	p.E500E	BNC1_ENST00000569704.1_Silent_p.E493E|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	500					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						TGTTTGCTACCTCGGCAGGCG	0.527000													33	62					0	0	1	0	0
KLHL12	59349	broad.mit.edu	37	1	202861773	202861773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202861773G>A	ENST00000367261.3	-	12	1813	c.1595C>T	c.(1594-1596)tCc>tTc	p.S532F	KLHL12_ENST00000367259.1_Missense_Mutation_p.P203S|KLHL12_ENST00000435533.3_Missense_Mutation_p.S570F	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	532	Interaction with DVL3.				Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			ACTTAGCAGGGAATTACCATC	0.488000													14	58					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873207	55873207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55873207C>T	ENST00000313503.1	+	1	689	c.689C>T	c.(688-690)tCc>tTc	p.S230F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					AAAATTAATTCCACTTCAGGA	0.373000										HNSCC(53;0.14)			41	91					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232941087	232941087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:232941087C>T	ENST00000418460.1	+	1	445	c.318C>T	c.(316-318)atC>atT	p.I106I		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		TTCCGCAAATCTCGCGAGATA	0.602000													15	56					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36759506	36759506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36759506G>A	ENST00000416516.2	-	4	2238	c.1748C>T	c.(1747-1749)tCt>tTt	p.S583F		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	583	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						CTCACCATCAGAGATATTGTC	0.552000													64	134					0	0	1	0	0
DBF4B	80174	broad.mit.edu	37	17	42825720	42825720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42825720C>T	ENST00000315005.3	+	13	1214	c.1076C>T	c.(1075-1077)tCc>tTc	p.S359F	DBF4B_ENST00000393547.2_Missense_Mutation_p.S359F	NM_145663.2	NP_663696.1	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B (S. cerevisiae)	359					cell cycle	nucleus	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)	7		Prostate(33;0.0322)				TGGTCAGGTTCCCCAGCTTCT	0.592000													48	101					0	0	1	0	0
PHF14	9678	broad.mit.edu	37	7	11068332	11068332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:11068332C>T	ENST00000403050.3	+	7	1794	c.1342C>T	c.(1342-1344)Cgc>Tgc	p.R448C	PHF14_ENST00000445996.2_Missense_Mutation_p.R163C	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	448							zinc ion binding	p.R448C(1)		NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		TGAAGACCCTCGCTTTGCTAG	0.433000													18	35					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9804648	9804648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9804648C>T	ENST00000256460.3	-	5	556	c.379G>A	c.(379-381)Gat>Aat	p.D127N	OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	127	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TTCACAGCATCCAGCACCTGG	0.607000													15	42					0	0	1	0	0
PARN	5073	broad.mit.edu	37	16	14711453	14711453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:14711453G>A	ENST00000437198.2	-	6	523	c.382C>T	c.(382-384)Cga>Tga	p.R128*	PARN_ENST00000566021.1_Intron|PARN_ENST00000341484.7_Nonsense_Mutation_p.R67*|PARN_ENST00000539279.1_Intron|PARN_ENST00000420015.2_Nonsense_Mutation_p.R82*	NM_001134477.2|NM_002582.3	NP_001127949.1|NP_002573.1	O95453	PARN_HUMAN	poly(A)-specific ribonuclease	128					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding	p.R128*(2)		cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|urinary_tract(1)	21						TTACCATTTCGAAAAACTTTA	0.358000													11	42					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60168850	60168850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:60168850C>T	ENST00000261187.4	+	4	938	c.774C>T	c.(772-774)ttC>ttT	p.F258F	SLC16A7_ENST00000543448.1_Silent_p.F159F|SLC16A7_ENST00000552024.1_Silent_p.F258F|SLC16A7_ENST00000547379.1_Silent_p.F258F|SLC16A7_ENST00000552432.1_Silent_p.F258F	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	258						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TCATTATGTTCCTAGGTTTTT	0.363000													8	107					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113218404	113218404	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113218404G>A	ENST00000295872.4	-	4	432	c.173C>T	c.(172-174)tCg>tTg	p.S58L		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	58					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						TCTATTCTTCGATTTGTGTAT	0.368000													15	29					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43351577	43351577	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43351577C>T	ENST00000395891.1	+	4	848	c.243C>T	c.(241-243)ctC>ctT	p.L81L	HECW1_ENST00000453890.1_Silent_p.L81L	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	81					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GCTCCACGCTCATGGTCAGCA	0.612000													21	73					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154886389	154886389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:154886389C>T	ENST00000460393.1	+	19	2009	c.1889C>T	c.(1888-1890)tCc>tTc	p.S630F	MME_ENST00000462745.1_Missense_Mutation_p.S630F|MME_ENST00000493237.1_Missense_Mutation_p.S630F|MME_ENST00000492661.1_Missense_Mutation_p.S630F|MME-AS1_ENST00000484721.1_RNA|MME_ENST00000360490.2_Missense_Mutation_p.S630F	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	630					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GGAAACTTTTCCTGGGACCTG	0.403000													38	101					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5222750	5222750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5222750G>A	ENST00000372412.4	-	18	3289	c.3056C>T	c.(3055-3057)cCt>cTt	p.P1019L	PTPRS_ENST00000588012.1_Missense_Mutation_p.P996L|PTPRS_ENST00000357368.4_Missense_Mutation_p.P1018L|PTPRS_ENST00000353284.2_Intron|PTPRS_ENST00000348075.2_Missense_Mutation_p.P996L|PTPRS_ENST00000592099.1_Intron|PTPRS_ENST00000588552.1_Intron|PTPRS_ENST00000587303.1_Missense_Mutation_p.P1018L|PTPRS_ENST00000262963.6_Missense_Mutation_p.P1014L			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1018	Fibronectin type-III 7.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GAAGGGGCCAGGGCCCCGGCG	0.746000													8	29					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40655966	40655966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40655966C>T	ENST00000267889.3	+	2	347	c.260C>T	c.(259-261)cCc>cTc	p.P87L		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	87					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCATCCAGCCCCTTGGCCCCT	0.652000													24	86					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115349528	115349528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115349528G>A	ENST00000369358.4	-	41	5253	c.5009C>T	c.(5008-5010)aCc>aTc	p.T1670I	NRAP_ENST00000360478.3_Missense_Mutation_p.T1627I|NRAP_ENST00000359988.3_Missense_Mutation_p.T1662I|NRAP_ENST00000369360.3_Missense_Mutation_p.T1635I			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1662						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		AACACCTCTGGTCAGGTTCAA	0.542000													28	94					0	0	1	0	0
CLSPN	63967	broad.mit.edu	37	1	36202572	36202572	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36202572G>A	ENST00000251195.5	-	24	3948	c.3852C>T	c.(3850-3852)gtC>gtT	p.V1284V	CLSPN_ENST00000318121.3_Silent_p.V1284V|CLSPN_ENST00000520551.1_Silent_p.V1231V|CLSPN_ENST00000466308.1_5'UTR|CLSPN_ENST00000373220.3_Silent_p.V1220V			Q9HAW4	CLSPN_HUMAN	claspin	1284					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTGTATGAAAGACAAAGTTTC	0.468000													49	93					0	0	1	0	0
NSMF	26012	broad.mit.edu	37	9	140347008	140347008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140347008G>A	ENST00000371475.3	-	11	1393	c.1162C>T	c.(1162-1164)Ctt>Ttt	p.L388F	NSMF_ENST00000371482.1_Missense_Mutation_p.L52F|NSMF_ENST00000437259.1_Missense_Mutation_p.L365F|NSMF_ENST00000339554.3_Missense_Mutation_p.L185F|NSMF_ENST00000371474.3_Missense_Mutation_p.L363F|NSMF_ENST00000371472.2_Missense_Mutation_p.L386F|NSMF_ENST00000541195.1_Missense_Mutation_p.L185F|NSMF_ENST00000371473.3_Missense_Mutation_p.L358F|NSMF_ENST00000265663.7_Missense_Mutation_p.L386F|NSMF_ENST00000392812.4_Missense_Mutation_p.L365F|NSMF_ENST00000484316.1_5'UTR|NSMF_ENST00000371468.1_3'UTR	NM_001130969.1	NP_001124441.1			NMDA receptor synaptonuclear signaling and neuronal migration factor																		CACATACCAAGGATGTCCTCG	0.657000													8	40					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9001395	9001395	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9001395C>T	ENST00000299698.7	+	16	2093	c.1913C>T	c.(1912-1914)cCa>cTa	p.P638L	A2ML1_ENST00000539547.1_Missense_Mutation_p.P147L	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	482						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						GTGTCTGGCCCATGGGACTTT	0.552000													42	226					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31342524	31342524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31342524C>T	ENST00000544665.3	+	29	3389	c.3318C>T	c.(3316-3318)ccC>ccT	p.P1106P	ITGAM_ENST00000287497.8_Silent_p.P1105P	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1105					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TCCCCAACCCCCTGCCGCTCA	0.672000													23	39					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100831	93100831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:93100831G>A	ENST00000544406.2	+	2	690	c.424G>A	c.(424-426)Gaa>Aaa	p.E142K	C12orf74_ENST00000397833.3_Missense_Mutation_p.E142K			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	142										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						GCCTGTCAATGAAGGGTCCCT	0.587000													27	53					0	0	1	0	0
PCDHB17P	54661	broad.mit.edu	37	5	140536603	140536603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140536603G>A	ENST00000539533.1	+	1	1027	c.1027G>A	c.(1027-1029)Gac>Aac	p.D343N																								GGATATAAACGACAACGCACC	0.448000													4	6					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267675	71267675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:71267675G>A	ENST00000554752.2	-	2	528	c.529C>T	c.(529-531)Cct>Tct	p.P177S	MAP3K9_ENST00000555993.2_Missense_Mutation_p.P177S|MAP3K9_ENST00000381250.4_Missense_Mutation_p.P177S			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	177	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TCCTCATCAGGGTCGTGGCGA	0.537000													15	142					0	0	1	0	0
C2orf76	130355	broad.mit.edu	37	2	120097505	120097505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120097505G>A	ENST00000409466.2	-	3	552	c.31C>T	c.(31-33)Cgc>Tgc	p.R11C	C2orf76_ENST00000409877.1_Missense_Mutation_p.R11C|C2orf76_ENST00000409523.1_Missense_Mutation_p.R11C|C2orf76_ENST00000334816.7_Missense_Mutation_p.R11C|C2orf76_ENST00000498049.1_5'UTR			Q3KRA6	CB076_HUMAN	chromosome 2 open reading frame 76	11										large_intestine(1)|lung(3)|pancreas(1)	5						CGGATGAGGCGAACTGTGATG	0.433000													17	60					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89925205	89925205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89925205G>A	ENST00000405460.2	+	9	1784	c.1688G>A	c.(1687-1689)gGa>gAa	p.G563E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	563					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATTCCTGCTGGAGCTGTGGAC	0.403000													11	57					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62415387	62415387	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62415387G>A	ENST00000330574.2	-	2	2217	c.2165C>T	c.(2164-2166)tCt>tTt	p.S722F		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	722					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						AGAAGCCAAAGAAGCTGAAAC	0.537000													10	69					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6590866	6590866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6590866G>A	ENST00000433363.2	-	11	1790	c.1557C>T	c.(1555-1557)caC>caT	p.H519H	SLC13A5_ENST00000293800.6_Silent_p.H502H|SLC13A5_ENST00000381074.4_Silent_p.H476H|SLC13A5_ENST00000573648.1_Intron	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	519						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						CAACCTTGAGGTGCCCATAGG	0.498000													36	66					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160793318	160793318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160793318C>T	ENST00000263285.5	+	8	1592	c.1562C>T	c.(1561-1563)cCc>cTc	p.P521L	LY9_ENST00000368035.1_Missense_Mutation_p.P159L|LY9_ENST00000368041.2_Missense_Mutation_p.P391L|LY9_ENST00000341032.4_Missense_Mutation_p.P417L|LY9_ENST00000368040.1_Missense_Mutation_p.P159L	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	521					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTGGACACTCCCCTCAGGCCT	0.557000													19	37					0	0	1	0	0
TRBV4-1	28617	broad.mit.edu	37	7	142013265	142013265	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142013265G>A	ENST00000390357.3	+	0	149																											AGAAGTCTTTGAAATGTGAAC	0.438000													33	78					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121350818	121350818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121350818C>T	ENST00000314583.3	-	14	1427	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.E409K	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	446	SH3.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		AAGGAAAGCTCATCACTTCCC	0.517000													48	132					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30585176	30585176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30585176G>A	ENST00000217299.3	+	3	1830	c.1656G>A	c.(1654-1656)gaG>gaA	p.E552E		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	552						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGGCACTGGAGTACTCCTCAC	0.602000													22	98					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149430317	149430317	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149430317C>T	ENST00000255992.10	+	18	2670	c.2271C>T	c.(2269-2271)ctC>ctT	p.L757L	KRBA1_ENST00000319551.8_Silent_p.L697L|KRBA1_ENST00000485033.2_Silent_p.L697L|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	758	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGAGGCTGCTCCCCCAGGGCC	0.642000													47	186					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38897326	38897326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38897326G>A	ENST00000359357.3	+	73	10761	c.10507G>A	c.(10507-10509)Gag>Aag	p.E3503K	RP1-207H1.3_ENST00000453417.1_RNA|DNAH8_ENST00000441566.1_Missense_Mutation_p.E3467K|RP1-207H1.3_ENST00000418399.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.E3720K|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CACACACTTGGAGGACAGCCT	0.408000													68	152					0	0	1	0	0
C1orf111	284680	broad.mit.edu	37	1	162344300	162344300	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:162344300C>T	ENST00000367935.4	-	3	403	c.324G>A	c.(322-324)gaG>gaA	p.E108E	C1orf111_ENST00000493255.1_5'UTR|RP11-565P22.6_ENST00000431696.1_Intron	NM_182581.3	NP_872387.2	Q5T0L3	CA111_HUMAN	chromosome 1 open reading frame 111	108										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11	all_hematologic(112;0.15)		BRCA - Breast invasive adenocarcinoma(70;0.0938)			CCAGCTGGCTCTCTTTGTCTG	0.572000													64	178					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3085322	3085322	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3085322C>T	ENST00000397461.1	+	22	3129	c.2745C>T	c.(2743-2745)tcC>tcT	p.S915S	CNTN4_ENST00000397459.2_Silent_p.S587S|CNTN4_ENST00000418658.1_Silent_p.S915S|CNTN4_ENST00000427331.1_Silent_p.S915S|CNTN4_ENST00000448906.2_Silent_p.S587S|CNTN4-AS1_ENST00000442749.2_RNA|CNTN4_ENST00000358480.3_Silent_p.S696S	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	915	Fibronectin type-III 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CATCAGACTCCAAAATTATCC	0.368000													23	67					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104643604	104643604	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104643604C>T	ENST00000315264.7	+	11	4440	c.4062C>T	c.(4060-4062)ccC>ccT	p.P1354P	KIF26A_ENST00000423312.2_Silent_p.P1493P			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1493					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCCCCAAGCCCCCTGTTGGTG	0.706000													5	10					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76990361	76990361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76990361G>A	ENST00000315938.4	-	3	387	c.137C>T	c.(136-138)tCa>tTa	p.S46L	GDPD4_ENST00000527489.1_Intron|GDPD4_ENST00000376217.2_Missense_Mutation_p.S46L	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	46					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						CAACAGCAATGAAGAGTAGGC	0.428000													14	36					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20585753	20585753	+	Missense_Mutation	SNP	C	C	T	rs150087607		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20585753C>T	ENST00000315543.4	+	1	188	c.188C>T	c.(187-189)tCg>tTg	p.S63L		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GCCCTCTTCTCGGTTATCTAT	0.408000													102	288					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4554475	4554475	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4554475G>A	ENST00000586582.1	-	9	1006	c.696C>T	c.(694-696)gtC>gtT	p.V232V	SEMA6B_ENST00000301293.3_Silent_p.V232V|SEMA6B_ENST00000586965.1_Silent_p.V232V	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	232	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCGCATGGACAAAGTAAG	0.547000													11	30					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56035641	56035641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56035641G>A	ENST00000244728.5	-	5	1229	c.832C>T	c.(832-834)Cct>Tct	p.P278S	COL21A1_ENST00000535941.1_Missense_Mutation_p.P278S|COL21A1_ENST00000370819.1_Missense_Mutation_p.P278S	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	278	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TATGATGGAGGAAGACCTTCT	0.358000													5	25					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170549	207170549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207170549G>A	ENST00000374423.3	+	5	1683	c.1297G>A	c.(1297-1299)Gaa>Aaa	p.E433K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	433							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CCTTTCCAAGGAAGTACGTAC	0.353000													29	66					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17450006	17450006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17450006C>T	ENST00000324894.8	+	6	807	c.739C>T	c.(739-741)Cgc>Tgc	p.R247C	GTPBP3_ENST00000361619.5_Missense_Mutation_p.R269C|GTPBP3_ENST00000598038.1_3'UTR|GTPBP3_ENST00000600625.1_Missense_Mutation_p.R247C|GTPBP3_ENST00000358792.7_Missense_Mutation_p.R279C	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	247					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						GCAGAGGCTCCGCTCAGGGGT	0.662000													19	30					0	0	1	0	0
ACVR2B	93	broad.mit.edu	37	3	38520723	38520723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38520723C>T	ENST00000352511.3	+	6	1243	c.771C>T	c.(769-771)ctC>ctT	p.L257L		NM_001106.3	NP_001097.2	Q13705	AVR2B_HUMAN	activin A receptor, type IIB	257	Protein kinase.				activin receptor signaling pathway|anterior/posterior pattern formation|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|regulation of transcription, DNA-dependent	cell surface|cytoplasm|integral to plasma membrane	activin receptor activity|ATP binding|growth factor binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			lung(1)	1	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0565)|Kidney(284;0.071)		GCTCCAACCTCGAAGTAGAGC	0.557000													62	144					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11199665	11199665	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11199665G>A	ENST00000361445.4	-	35	4999	c.4923C>T	c.(4921-4923)tcC>tcT	p.S1641S	MTOR_ENST00000495435.1_5'UTR	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1641	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TGACCACAAGGGACCGCACCA	0.502000													60	154					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189898822	189898822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189898822C>T	ENST00000374866.3	-	54	4748	c.4474G>A	c.(4474-4476)Gaa>Aaa	p.E1492K		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1492	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGCCCAATTTCAACGCCGAAT	0.463000													30	53					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21628917	21628917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21628917G>A	ENST00000328843.6	+	12	2096	c.2065G>A	c.(2065-2067)Gaa>Aaa	p.E689K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E689K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	689	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TATCTATAATGAATGGAAAAG	0.343000									Kartagener syndrome				10	75					0	0	1	0	0
KIZ-AS1	101929591	broad.mit.edu	37	20	21143493	21143493	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:21143493C>T	ENST00000591761.1	-	0	5085				PLK1S1_ENST00000457464.1_RNA|RP5-872K7.7_ENST00000425746.2_RNA																							ACTTGCAGATCATCTTGCTCA	0.443000													10	24					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69665943	69665943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:69665943C>T	ENST00000370598.1	+	7	2044	c.1223C>T	c.(1222-1224)tCg>tTg	p.S408L		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	408	TSP type-1 3.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GAGTGGAGTTCGTGGAGCCAG	0.527000													13	30					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55021669	55021669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:55021669C>T	ENST00000324000.3	+	2	2250	c.216C>T	c.(214-216)ttC>ttT	p.F72F		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	72					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		ACCCGTCATTCGTGCCCATTA	0.498000													29	164					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138633243	138633243	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:138633243T>A	ENST00000218099.2	+	6	550	c.543T>A	c.(541-543)gtT>gtA	p.V181V	F9_ENST00000394090.2_Silent_p.V143V	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	181					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GTGGAAGAGTTTCTGTTTCAC	0.348000													28	17					0	0	1	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79854699	79854699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79854699G>A	ENST00000338682.3	-	5	1812	c.1140C>T	c.(1138-1140)acC>acT	p.T380T		NM_001004441.2	NP_001004441.2	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	380						cytoplasm|nucleus				NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	28		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		AAGTTGGAGGGGTAAGGCCAG	0.428000													24	53					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4787833	4787833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4787833C>T	ENST00000299320.5	+	3	640	c.162C>T	c.(160-162)ttC>ttT	p.F54F	C16orf71_ENST00000590191.1_Silent_p.F54F|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	54										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						TGTTCATCTTCCAGCGAAACC	0.597000													27	66					0	0	1	0	0
ASIC5	51802	broad.mit.edu	37	4	156757929	156757929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156757929G>A	ENST00000537611.2	-	8	1193	c.1147C>T	c.(1147-1149)Ccg>Tcg	p.P383S		NM_017419.2	NP_059115.1	Q9NY37	ACCN5_HUMAN	acid-sensing (proton-gated) ion channel family member 5	383						integral to membrane|plasma membrane											ATAGTGGCCGGGTATTCTATT	0.363000													43	97					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167494	140167494	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140167494G>A	ENST00000458420.3	+	6	1111	c.921G>A	c.(919-921)ggG>ggA	p.G307G		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	307					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						ATTACATTGGGAAGGGTTGTG	0.483000										HNSCC(16;0.037)			22	119					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3658723	3658723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:3658723C>T	ENST00000404826.2	+	2	449	c.310C>T	c.(310-312)Cca>Tca	p.P104S	SDK1_ENST00000389531.3_Missense_Mutation_p.P104S	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	104	Ig-like C2-type 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGATGTTGCTCCATATTTTAA	0.398000													6	18					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479590	4479590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4479590C>T	ENST00000237837.1	-	3	820	c.675G>A	c.(673-675)ggG>ggA	p.G225G		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	225					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CCCTGACCACCCCTAATGGGT	0.697000													14	43					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18462396	18462396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:18462396C>T	ENST00000338745.6	-	2	1798	c.64G>A	c.(64-66)Gat>Aat	p.D22N	SATB1_ENST00000493952.2_Missense_Mutation_p.D22N|SATB1_ENST00000417717.2_Missense_Mutation_p.D22N|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Missense_Mutation_p.D22N	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	22					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						CCCTTCGGATCACTCACATTG	0.498000													64	122					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169539831	169539831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169539831C>T	ENST00000340806.6	+	1	122	c.122C>T	c.(121-123)cCt>cTt	p.P41L		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	41										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ACTGCCATTCCTTTGGAGATC	0.383000													35	84					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38610501	38610501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38610501G>A	ENST00000222345.6	+	9	3356	c.2847G>A	c.(2845-2847)agG>agA	p.R949R		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	949					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGACATAAGGGAGATAGTGC	0.532000													12	37					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141598235	141598235	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141598235T>A	ENST00000442267.2	-	6	946	c.872A>T	c.(871-873)aAg>aTg	p.K291M		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	291						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TCTCTCACTCTTTGCCCTGGC	0.423000													46	95					0	0	1	0	0
IRF6	3664	broad.mit.edu	37	1	209961772	209961772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209961772G>A	ENST00000367021.3	-	9	1569	c.1397C>T	c.(1396-1398)cCc>cTc	p.P466L	IRF6_ENST00000542854.1_Missense_Mutation_p.P371L	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	466					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CAATTACTGGGGAGGCAGGGC	0.458000										HNSCC(57;0.16)			16	43					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173787010	173787010	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:173787010G>A	ENST00000397081.3	+	6	662	c.517_splice	c.e6-1	p.R173_splice	RAPGEF4_ENST00000538974.1_Splice_Site_p.R20_splice|RAPGEF4_ENST00000473043.1_3'UTR|RAPGEF4_ENST00000539331.1_Splice_Site_p.R20_splice|RAPGEF4_ENST00000540783.1_Splice_Site_p.R20_splice|RAPGEF4_ENST00000409036.1_Splice_Site_p.R173_splice|RAPGEF4_ENST00000397087.3_Splice_Site_p.R29_splice|RAPGEF4_ENST00000264111.6_Intron	NM_007023.3	NP_008954.2	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	173					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CTCCTTTAGGGATTCCTGACA	0.368000													82	207					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543236	28543236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28543236C>T	ENST00000452236.2	-	3	1863	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	416	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TGTGCAACTTCCGTAGGCCTT	0.388000													21	62					0	0	1	0	0
TFPI	7035	broad.mit.edu	37	2	188332533	188332533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:188332533C>T	ENST00000233156.3	-	7	1049	c.755G>A	c.(754-756)gGa>gAa	p.G252E	AC007319.1_ENST00000453517.1_RNA|AC007319.1_ENST00000412276.1_RNA|TFPI_ENST00000392365.1_Missense_Mutation_p.G252E	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	252	BPTI/Kunitz inhibitor 3.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	GTTTTCATTTCCCCCACATCC	0.393000													41	118					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510576	56510576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56510576G>A	ENST00000302957.3	-	1	711	c.712C>T	c.(712-714)Ctg>Ttg	p.L238L		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AGGATAGCCAGGAGGATGTTG	0.478000													10	97					0	0	1	0	0
FCER1G	2207	broad.mit.edu	37	1	161188701	161188701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161188701G>A	ENST00000289902.1	+	5	254	c.229G>A	c.(229-231)Gag>Aag	p.E77K	FCER1G_ENST00000490414.1_3'UTR|FCER1G_ENST00000367992.3_Intron	NM_004106.1	NP_004097.1	P30273	FCERG_HUMAN	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	77	ITAM.				platelet activation	integral to plasma membrane				endometrium(1)|lung(5)	6	all_cancers(52;1.35e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Benzylpenicilloyl Polylysine(DB00895)	GGAGACTTACGAGACTCTGAA	0.542000													26	82					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52822481	52822481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52822481C>T	ENST00000252245.5	-	6	1302	c.1082G>A	c.(1081-1083)cGa>cAa	p.R361Q		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	361	Coil 2.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		TTTGGTGTTTCGAAGGTCATC	0.527000													12	79					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167802338	167802338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167802338G>A	ENST00000367848.1	-	25	3701	c.3204C>T	c.(3202-3204)ctC>ctT	p.L1068L	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.L1160L|ADCY10_ENST00000545172.1_Silent_p.L1007L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1160					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTCGGTTGAGGAGCTTCAGTG	0.453000													101	246					0	0	1	0	0
OLFM4	10562	broad.mit.edu	37	13	53603060	53603060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:53603060C>T	ENST00000219022.2	+	1	167	c.89C>T	c.(88-90)cCc>cTc	p.P30L		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	30					cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CCTCCAATTCCCAGCCCCGGC	0.602000													46	191					0	0	1	0	0
SCGB1D4	404552	broad.mit.edu	37	11	62065000	62065000	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62065000C>T	ENST00000358585.1	-	2	239	c.186G>A	c.(184-186)gtG>gtA	p.V62V		NM_206998.1	NP_996881.1	Q6XE38	SG1D4_HUMAN	secretoglobin, family 1D, member 4	62						extracellular region	binding			lung(1)|prostate(1)	2						TGCAGTGCTTCACTTCCAACT	0.428000													97	261					0	0	1	0	0
CIB1	10519	broad.mit.edu	37	15	90775465	90775465	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90775465G>A	ENST00000328649.6	-	3	342	c.181C>T	c.(181-183)Ctt>Ttt	p.L61F		NM_006384.3	NP_006375.2	Q99828	CIB1_HUMAN	calcium and integrin binding 1 (calmyrin)	61					apoptosis|cell adhesion|double-strand break repair	apical plasma membrane|endoplasmic reticulum|filopodium|nucleoplasm	calcium ion binding|protein binding			lung(1)|prostate(1)	2	Melanoma(11;0.00551)|Lung NSC(78;0.0141)|all_lung(78;0.0303)		BRCA - Breast invasive adenocarcinoma(143;0.00269)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			AGCTCTGGAAGGCTGAGAATC	0.597000													29	122					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51464870	51464870	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51464870C>T	ENST00000298355.3	-	7	2622	c.1501G>A	c.(1501-1503)Gat>Aat	p.D501N	TRIM9_ENST00000338969.5_Missense_Mutation_p.D497N|TRIM9_ENST00000360392.4_Missense_Mutation_p.D501N	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	501	Fibronectin type-III.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					TGAAGACCATCCACAGTGCAC	0.552000													21	67					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125836936	125836936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125836936G>A	ENST00000393434.2	-	17	2243	c.1894C>T	c.(1894-1896)Ctg>Ttg	p.L632L	ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000472186.1_Silent_p.L632L|ALDH1L1_ENST00000452905.2_Silent_p.L531L|ALDH1L1_ENST00000273450.3_Silent_p.L642L	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	632	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TGGCCGACCAGGGAGCCTGTG	0.627000													4	34					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73563112	73563112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73563112G>A	ENST00000224721.6	+	54	7827	c.7822G>A	c.(7822-7824)Gac>Aac	p.D2608N	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Missense_Mutation_p.D363N	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2603	Cadherin 24.		R -> H (in DFNB12).		calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GGAGGTCATCGACGTCAATGA	0.622000													3	11					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68882034	68882034	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:68882034C>T	ENST00000303786.3	+	3	928	c.508C>T	c.(508-510)Ctg>Ttg	p.L170L	PROKR1_ENST00000394342.2_Silent_p.L170L			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	170						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TGTCCATCCGCTGAGACCACG	0.498000													46	96					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92532279	92532279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92532279G>A	ENST00000298047.6	+	9	6117	c.6100G>A	c.(6100-6102)Gtc>Atc	p.V2034I	FAT3_ENST00000525166.1_Missense_Mutation_p.V1884I|FAT3_ENST00000409404.2_Missense_Mutation_p.V2034I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2034	Cadherin 18.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TACCTCAGGGGTCATTCAGAC	0.463000										TCGA Ovarian(4;0.039)			22	51					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131231365	131231365	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:131231365C>T	ENST00000298542.4	-	4	388	c.213G>A	c.(211-213)aaG>aaA	p.K71K	FRMD7_ENST00000464296.1_Intron	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	71	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					AAACAATCTCCTTAGGATCTT	0.388000													18	106					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79514186	79514186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79514186G>A	ENST00000537152.1	-	5	1994	c.1469C>T	c.(1468-1470)cCc>cTc	p.P490L	C17orf70_ENST00000425898.2_Missense_Mutation_p.P290L|C17orf70_ENST00000327787.8_Missense_Mutation_p.P641L	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	641					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CCTGCTCAGGGGCAGGCAAAC	0.692000													21	88					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203019	140203019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140203019C>T	ENST00000529859.1	+	1	1659	c.1659C>T	c.(1657-1659)ttC>ttT	p.F553F	PCDHA5_ENST00000529619.1_Silent_p.F553F|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000378126.3_Silent_p.F553F|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGTGTTCGTGCTGGACG	0.706000													31	77					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76368516	76368516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76368516C>T	ENST00000298832.9	+	31	3977	c.3772C>T	c.(3772-3774)Ctc>Ttc	p.L1258F		NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1258					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		GCTGAATGGACTCCAGAGCAG	0.572000													19	88					0	0	1	0	0
BCORP1	286554	broad.mit.edu	37	Y	21635879	21635879	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:21635879C>T	ENST00000441139.1	-	0	663					NR_002923.2																						GTTTCTCTTTCATGATATCAC	0.493000													7	4					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855782	12855782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12855782C>T	ENST00000332296.7	+	4	1165	c.1062C>T	c.(1060-1062)ctC>ctT	p.L354L	PRAMEF1_ENST00000400814.3_Silent_p.L109L	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	354										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAAAACCCTCATCTTGGAGG	0.537000													63	357					0	0	1	0	0
PXK	54899	broad.mit.edu	37	3	58382778	58382778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58382778C>T	ENST00000463280.1	+	8	827	c.736C>T	c.(736-738)Ctt>Ttt	p.L246F	PXK_ENST00000536660.1_Missense_Mutation_p.L142F|PXK_ENST00000479241.1_Missense_Mutation_p.L262F|PXK_ENST00000484288.1_Missense_Mutation_p.L279F|PXK_ENST00000383716.3_Missense_Mutation_p.L246F|PXK_ENST00000383715.4_Missense_Mutation_p.L262F|PXK_ENST00000356151.2_Missense_Mutation_p.L279F|PXK_ENST00000302779.5_Missense_Mutation_p.L262F			Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	279	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		ACTGAAGTTTCTTCATGACAA	0.398000													52	119					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77257047	77257047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77257047G>A	ENST00000251089.2	-	9	1871	c.1759C>T	c.(1759-1761)Cgc>Tgc	p.R587C	ANGEL1_ENST00000557179.1_Missense_Mutation_p.R152C	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	587										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		ACCTCTGGGCGGCCACGCTGG	0.512000													4	42					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20691984	20691984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20691984G>A	ENST00000315519.2	+	1	194	c.116G>A	c.(115-117)aGg>aAg	p.R39K		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		CATGGTCAAAGGGAGATGCAG	0.463000													52	155					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4835838	4835838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4835838C>T	ENST00000252318.2	+	2	689	c.352C>T	c.(352-354)Ctc>Ttc	p.L118F	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	118						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CCAAATGAAACTCTTCCCACA	0.507000													11	26					0	0	1	0	0
ACTL6B	51412	broad.mit.edu	37	7	100244607	100244607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100244607G>A	ENST00000160382.5	-	10	1029	c.923C>T	c.(922-924)cCc>cTc	p.P308L		NM_016188.4	NP_057272.1	O94805	ACL6B_HUMAN	actin-like 6B	308					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GACGTTCGAGGGATCAAACAG	0.622000													7	55					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64664000	64664000	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64664000G>A	ENST00000421419.2	-	39	5481	c.5367C>T	c.(5365-5367)gcC>gcT	p.A1789A	ATG2A_ENST00000377264.3_Silent_p.A1787A			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1787							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						AGCCAAAGGAGGCAGCCCCTC	0.637000											OREG0004026	type=REGULATORY REGION|Gene=BC027481|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	14	29					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313046	54313046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54313046C>T	ENST00000324134.6	-	3	2035	c.1867G>A	c.(1867-1869)Gag>Aag	p.E623K	NLRP12_ENST00000354278.3_Missense_Mutation_p.E623K|NLRP12_ENST00000391772.1_Missense_Mutation_p.E623K|NLRP12_ENST00000351894.4_Missense_Mutation_p.E623K|NLRP12_ENST00000391775.3_Missense_Mutation_p.E623K|NLRP12_ENST00000535162.1_Missense_Mutation_p.E623K|NLRP12_ENST00000345770.5_Missense_Mutation_p.E623K|NLRP12_ENST00000391773.1_Missense_Mutation_p.E623K	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	623					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		ATAAACTCCTCCTCCTGGATC	0.567000													23	65					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136562429	136562429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136562429G>A	ENST00000264162.2	-	10	4382	c.4372C>T	c.(4372-4374)Cct>Tct	p.P1458S		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1458	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GTTCCATCAGGGAGGATGCGA	0.562000													20	37					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13397555	13397555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13397555G>A	ENST00000360228.5	-	20	3314	c.3315C>T	c.(3313-3315)ccC>ccT	p.P1105P	CACNA1A_ENST00000573710.2_Silent_p.P1106P	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1106			G -> S (in dbSNP:rs16027).		cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGGCCAGCATGGGGCCGGGGT	0.726000													6	18					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63525115	63525115	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:63525115C>T	ENST00000536984.2	+	8	1993	c.1299C>T	c.(1297-1299)gtC>gtT	p.V433V	CDH7_ENST00000323011.3_Silent_p.V433V|CDH7_ENST00000397968.2_Silent_p.V433V			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	433	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				ACAGTGGGGTCATCACAACTG	0.388000													28	114					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22157999	22157999	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22157999G>A	ENST00000374695.3	-	83	11488	c.11409C>T	c.(11407-11409)gaC>gaT	p.D3803D		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3803	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGGCACCATAGTCAGGATAGC	0.627000													14	66					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26691277	26691277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26691277G>A	ENST00000436292.1	-	4	880	c.760C>T	c.(760-762)Ctt>Ttt	p.L254F	ZNF683_ENST00000374204.1_Missense_Mutation_p.L254F|ZNF683_ENST00000403843.1_Missense_Mutation_p.L254F|ZNF683_ENST00000349618.3_Missense_Mutation_p.L254F			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGGTAGGGAAGCAGGGTCTCC	0.652000													34	43					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175334294	175334294	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175334294C>T	ENST00000367674.1	-	12	3147	c.2439G>A	c.(2437-2439)gaG>gaA	p.E813E	TNR_ENST00000263525.2_Silent_p.E813E	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	813	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TCTCTTCCTCCTCATCCCTGG	0.527000													25	46					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118343602	118343602	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118343602C>T	ENST00000534358.1	+	3	1751	c.1728C>T	c.(1726-1728)tcC>tcT	p.S576S	KMT2A_ENST00000354520.4_Silent_p.S576S|KMT2A_ENST00000389506.5_Silent_p.S576S	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AGCCAGCCTCCAGTATCTCTG	0.532000													38	84					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21245915	21245915	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21245915C>T	ENST00000233242.1	-	18	2732		c.e18-1			NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B						cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGCCTGCATCTATAAGTCAG	0.473000													29	72					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54959231	54959231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54959231G>A	ENST00000273286.5	-	2	181	c.19C>T	c.(19-21)Ctg>Ttg	p.L7L	CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_5'UTR|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	7						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		CTGGAAAACAGGAGCAGTTCA	0.463000													10	37					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23884842	23884842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23884842G>A	ENST00000355349.3	-	35	5315	c.5153C>T	c.(5152-5154)tCc>tTc	p.S1718F	CTD-2201G16.1_ENST00000557368.1_RNA	NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1718					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCTCACCTGGGAATGCAGCAG	0.597000													23	54					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725003	140725003	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140725003G>A	ENST00000253812.6	+	1	1403	c.1403G>A	c.(1402-1404)gGa>gAa	p.G468E	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1												p.G468E(1)		breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCCCAGAGGAGCCTCCATC	0.537000													33	245					0	0	1	0	0
KCNK17	89822	broad.mit.edu	37	6	39267378	39267378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39267378G>A	ENST00000373231.4	-	5	1056	c.824C>T	c.(823-825)tCc>tTc	p.S275F	KCNK17_ENST00000453413.2_3'UTR	NM_031460.3	NP_113648.2	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	275						integral to membrane	potassium channel activity|voltage-gated ion channel activity	p.S275F(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)	14						GTGGCAGCAGGAACATACCCT	0.562000													27	58					0	0	1	0	0
FBXL13	222235	broad.mit.edu	37	7	102665589	102665589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:102665589C>T	ENST00000393772.2	-	6	842	c.416G>A	c.(415-417)cGa>cAa	p.R139Q	FBXL13_ENST00000379305.3_Missense_Mutation_p.R139Q|FBXL13_ENST00000379306.3_Missense_Mutation_p.R139Q|FBXL13_ENST00000313221.4_Missense_Mutation_p.R139Q|FBXL13_ENST00000471074.1_5'UTR|FBXL13_ENST00000456695.1_Missense_Mutation_p.R139Q|FBXL13_ENST00000455112.2_Missense_Mutation_p.R139Q|FBXL13_ENST00000436908.1_Missense_Mutation_p.R139Q|FBXL13_ENST00000379308.3_Missense_Mutation_p.R139Q			Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13	139										NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|skin(3)|stomach(1)	27						AGAAGAACTTCGTTCAGGAAA	0.318000													7	44					0	0	1	0	0
KHDC3L	154288	broad.mit.edu	37	6	74073386	74073386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:74073386G>A	ENST00000370367.3	+	3	510	c.457G>A	c.(457-459)Gag>Aag	p.E153K		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		GGAGGTCCGGGAGGCCGGGAC	0.677000													26	33					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137716508	137716508	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137716508C>T	ENST00000371817.3	+	62	5175	c.4761C>T	c.(4759-4761)atC>atT	p.I1587I		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1587	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGCGGAACATCGACGCCAGCC	0.642000													13	41					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123485474	123485474	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123485474T>A	ENST00000529750.1	+	16	2147	c.1820T>A	c.(1819-1821)aTc>aAc	p.I607N	GRAMD1B_ENST00000322282.7_Missense_Mutation_p.I607N|GRAMD1B_ENST00000456860.2_Missense_Mutation_p.I614N|GRAMD1B_ENST00000450171.2_Missense_Mutation_p.I298N	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	607						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		ACGCGGCATATCCCGGAGGAC	0.547000													9	25					0	0	1	0	0
FAM76B	143684	broad.mit.edu	37	11	95521709	95521709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:95521709G>A	ENST00000358780.5	-	2	418	c.106C>T	c.(106-108)Cct>Tct	p.P36S	FAM76B_ENST00000538047.1_5'UTR|FAM76B_ENST00000536839.1_Missense_Mutation_p.P36S	NM_144664.4	NP_653265.3	Q5HYJ3	FA76B_HUMAN	family with sequence similarity 76, member B	36										breast(1)|kidney(1)|lung(1)	3		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTTACAATAGGATGTGCAATC	0.343000													9	59					0	0	1	0	0
MTERFD1	51001	broad.mit.edu	37	8	97258141	97258141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:97258141G>A	ENST00000523821.1	-	6	963	c.844C>T	c.(844-846)Cgt>Tgt	p.R282C	MTERFD1_ENST00000522822.1_Missense_Mutation_p.R161C|MTERFD1_ENST00000524341.1_Missense_Mutation_p.R92C|MTERFD1_ENST00000287025.3_Missense_Mutation_p.R282C			Q96E29	MTER1_HUMAN	MTERF domain containing 1	282					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	24	Breast(36;5.16e-05)					CTTGGGAGACGAACTACCAGA	0.363000													25	88					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31653928	31653928	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:31653928C>T	ENST00000395934.2	+	7	910	c.903C>T	c.(901-903)atC>atT	p.I301I	ELP4_ENST00000350638.5_Silent_p.I301I|ELP4_ENST00000379163.5_Silent_p.I302I			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	301					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					CCTGCATCATCACAATGCCAA	0.398000													43	74					0	0	1	0	0
CD300E	342510	broad.mit.edu	37	17	72619772	72619772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72619772C>T	ENST00000392619.1	-	1	105	c.70G>A	c.(70-72)Gga>Aga	p.G24R	CD300E_ENST00000328630.3_5'UTR|CD300E_ENST00000426295.2_Missense_Mutation_p.G38R	NM_181449.2	NP_852114.2	Q496F6	CLM2_HUMAN	CD300e molecule	0	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			breast(1)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	19						TTCCTGTCTCCTTGGCTTCCG	0.537000													40	82					0	0	1	0	0
CLDN4	1364	broad.mit.edu	37	7	73246037	73246037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73246037C>T	ENST00000435050.1	+	2	3186	c.506C>T	c.(505-507)gCc>gTc	p.A169V	CLDN4_ENST00000431918.1_Missense_Mutation_p.A169V|CLDN4_ENST00000340958.2_Missense_Mutation_p.A169V			O14493	CLD4_HUMAN	claudin 4	169					calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity			kidney(2)|lung(4)|urinary_tract(1)	7		Lung NSC(55;0.159)				GTCGGCTGGGCCGCCTCCGGC	0.642000													16	56					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	157999191	157999191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:157999191G>A	ENST00000264428.4	+	2	285	c.15G>A	c.(13-15)ttG>ttA	p.L5L	GLRB_ENST00000541722.1_Silent_p.L5L|GLRB_ENST00000512619.1_Silent_p.L5L|GLRB_ENST00000509282.1_Silent_p.L5L	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	5					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	AGTTTTTATTGACAACTGCCT	0.313000													7	43					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451765	55451765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55451765C>T	ENST00000588756.1	-	6	908	c.422G>A	c.(421-423)gGa>gAa	p.G141E	NLRP7_ENST00000328092.5_Missense_Mutation_p.G141E|NLRP7_ENST00000340844.2_Missense_Mutation_p.G141E|NLRP7_ENST00000448121.2_Missense_Mutation_p.G141E|NLRP7_ENST00000590030.1_Missense_Mutation_p.G141E|NLRP7_ENST00000592784.1_Missense_Mutation_p.G141E|NLRP7_ENST00000446217.1_Missense_Mutation_p.G169E			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	141							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GTCAATGTCTCCTTGCCAAAA	0.463000													178	453					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45945563	45945563	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45945563A>G	ENST00000323084.4	-	8	1374	c.1309T>C	c.(1309-1311)Ttc>Ctc	p.F437L	C21orf90_ENST00000465978.1_Intron|TSPEAR_ENST00000397916.1_Missense_Mutation_p.F369L	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	437					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						ACCGCCAGGAAGTGCTCCCCA	0.602000													47	119					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64461881	64461881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:64461881C>T	ENST00000358025.3	+	23	3131	c.2901C>T	c.(2899-2901)atC>atT	p.I967I	SYNE2_ENST00000344113.4_Silent_p.I967I|SYNE2_ENST00000554584.1_Silent_p.I967I|SYNE2_ENST00000357395.3_5'UTR	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	967					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGAAACTTATCCGTAGAGGAA	0.294000													11	46					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23808660	23808660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23808660G>A	ENST00000354639.3	+	12	1858	c.1394G>A	c.(1393-1395)gGa>gAa	p.G465E	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Missense_Mutation_p.G488E|STK31_ENST00000355870.3_Missense_Mutation_p.G488E|STK31_ENST00000428484.1_Missense_Mutation_p.G465E	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	488							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GCCAAAGAAGGAGCAAATTCT	0.358000													41	120					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54792345	54792345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54792345G>A	ENST00000545554.1	+	20	5129	c.5129G>A	c.(5128-5130)gGa>gAa	p.G1710E	UNC13C_ENST00000537900.1_Missense_Mutation_p.G1708E|UNC13C_ENST00000260323.11_Missense_Mutation_p.G1710E			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1710	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTCCTTCATGGAGCACTGGGA	0.353000													6	24					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159174755	159174755	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159174755G>A	ENST00000537147.1	+	2	849	c.6G>A	c.(4-6)ggG>ggA	p.G2G	DARC_ENST00000368122.2_Silent_p.G2G			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	2					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					GTGCCATGGGGAACTGTCTGC	0.572000													25	70					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62632583	62632583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62632583C>T	ENST00000535781.1	+	9	1288	c.1177C>T	c.(1177-1179)Ctt>Ttt	p.L393F	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	393					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GAAGCGGGTTCTTCGGAAAGG	0.587000													23	39					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55184358	55184358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:55184358C>T	ENST00000337714.3	+	2	1766	c.1533C>T	c.(1531-1533)ttC>ttT	p.F511F	AKAP1_ENST00000571629.1_Silent_p.F511F|AKAP1_ENST00000572557.1_Silent_p.F511F|AKAP1_ENST00000314126.3_Silent_p.F511F|AKAP1_ENST00000539273.1_Silent_p.F511F	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	511					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					CAGATTCTTTCAGCACTTCAG	0.567000													68	185					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326001	152326001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152326001C>T	ENST00000388718.5	-	3	4333	c.4261G>A	c.(4261-4263)Gga>Aga	p.G1421R	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1421							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCCAGATCCCCTTCTTCCA	0.527000													139	340					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77376986	77376986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77376986C>T	ENST00000451710.3	-	26	4838	c.4601G>A	c.(4600-4602)aGg>aAg	p.R1534K	TRPM6_ENST00000376864.4_Missense_Mutation_p.R1534K|TRPM6_ENST00000361255.3_Missense_Mutation_p.R1529K|TRPM6_ENST00000360774.1_Missense_Mutation_p.R1534K|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Missense_Mutation_p.R1529K			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1534					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AGCGAAGGGCCTGTATCTGCG	0.413000													13	75					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784321	9784321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9784321G>A	ENST00000304374.2	+	1	1064	c.668G>A	c.(667-669)cGa>cAa	p.R223Q		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	223					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.R223Q(1)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	AGCCTGAATCGAACCTACGCC	0.582000													31	91					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113170685	113170685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113170685G>A	ENST00000401783.2	-	38	7531	c.7195C>T	c.(7195-7197)Cat>Tat	p.H2399Y	SVEP1_ENST00000374469.1_Missense_Mutation_p.H2376Y|SVEP1_ENST00000297826.5_Missense_Mutation_p.H325Y	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2399	Sushi 17.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTTCCAAAATGAAGAGCAGAA	0.458000													9	26					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13823467	13823467	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13823467C>T	ENST00000265104.4	-	40	6696	c.6592G>A	c.(6592-6594)Gaa>Aaa	p.E2198K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2198					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AACAAGGGTTCATCCTCATCA	0.368000									Kartagener syndrome				27	89					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86277262	86277262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:86277262G>A	ENST00000314673.3	-	5	627	c.451C>T	c.(451-453)Ccg>Tcg	p.P151S	SNX14_ENST00000505648.1_Missense_Mutation_p.P99S|SNX14_ENST00000369627.2_Missense_Mutation_p.P151S|SNX14_ENST00000346348.3_Intron|RP11-321N4.5_ENST00000503906.1_3'UTR|SNX14_ENST00000513865.1_Missense_Mutation_p.P151S|SNX14_ENST00000508980.1_5'UTR	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	151	PXA.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CTGTACCACGGATAAACAAAG	0.274000													21	60					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111145995	111145995	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111145995C>T	ENST00000485317.1	-	3	2083	c.1410G>A	c.(1408-1410)gaG>gaA	p.E470E	KCNA2_ENST00000440270.1_Silent_p.E470E|KCNA2_ENST00000316361.4_Silent_p.E470E|KCNA2_ENST00000369770.3_Intron			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	470						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CTCTAAAGTCCTCATTACTGT	0.388000													21	131					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541680	133541680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133541680C>T	ENST00000409261.1	-	14	3077	c.2704G>A	c.(2704-2706)Gag>Aag	p.E902K	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.E902K	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	902							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TCACTAGACTCAATGGCAGGC	0.647000													18	55					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44250212	44250212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44250212C>T	ENST00000371505.4	-	4	1053	c.931G>A	c.(931-933)Gag>Aag	p.E311K	TCTE1_ENST00000371504.1_Intron|TMEM151B_ENST00000438774.2_Intron|TCTE1_ENST00000371503.3_Intron	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	311										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AAGTCCAGCTCCTCGAGGACT	0.567000													8	96					0	0	1	0	0
MEDAG	84935	broad.mit.edu	37	13	31495738	31495738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:31495738G>A	ENST00000380482.4	+	4	867	c.542G>A	c.(541-543)gGa>gAa	p.G181E	TEX26-AS1_ENST00000588726.1_RNA|TEX26-AS1_ENST00000592950.1_RNA|TEX26-AS1_ENST00000590344.1_RNA|TEX26-AS1_ENST00000451495.2_RNA|TEX26-AS1_ENST00000593246.1_RNA|TEX26-AS1_ENST00000586973.1_RNA|TEX26-AS1_ENST00000590721.1_RNA|TEX26-AS1_ENST00000585870.1_RNA|TEX26-AS1_ENST00000586464.1_RNA	NM_032849.3	NP_116238.2			mesenteric estrogen-dependent adipogenesis																		TTCCCCCCAGGAAATGAAGTG	0.358000													33	77					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72146332	72146332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72146332C>T	ENST00000268482.3	+	27	4129	c.3620C>T	c.(3619-3621)cCa>cTa	p.P1207L	PMFBP1_ENST00000537792.1_3'UTR|DHX38_ENST00000536867.1_Missense_Mutation_p.P519L	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1207					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				ATCTACACTCCAGGCCGGAAA	0.627000													42	74					0	0	1	0	0
NCAM2	4685	broad.mit.edu	37	21	22790820	22790820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:22790820G>A	ENST00000400546.1	+	11	1660	c.1411G>A	c.(1411-1413)Gga>Aga	p.G471R	NCAM2_ENST00000284894.7_Missense_Mutation_p.G329R	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	471	Ig-like C2-type 5.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CAATGACTTTGGACGCTATAA	0.318000													19	162					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109365066	109365066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109365066C>T	ENST00000356711.2	+	3	410	c.284C>T	c.(283-285)tCc>tTc	p.S95F	MYO16_ENST00000357550.2_Missense_Mutation_p.S95F|MYO16_ENST00000251041.5_Missense_Mutation_p.S95F	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	95					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCGGGAGGGTCCCTGCTCCAT	0.562000													36	95					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263316	248263316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248263316C>T	ENST00000366478.2	+	3	976	c.639C>T	c.(637-639)atC>atT	p.I213I	OR2L13_ENST00000358120.2_Silent_p.I213I	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TCATTGGCATCACTTCTTCCT	0.428000													26	82					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102965001	102965001	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:102965001C>T	ENST00000504592.1	+	15	2279	c.1861C>T	c.(1861-1863)Caa>Taa	p.Q621*	BANK1_ENST00000322953.4_Nonsense_Mutation_p.Q636*|BANK1_ENST00000444316.2_Nonsense_Mutation_p.Q606*|BANK1_ENST00000428908.1_Nonsense_Mutation_p.Q503*|BANK1_ENST00000508653.1_Nonsense_Mutation_p.Q503*			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	636					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TACAGTGTTTCAACAAAAGAC	0.328000													73	153					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196619103	196619103	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196619103C>T	ENST00000312428.6	-	63	11822	c.11722G>A	c.(11722-11724)Gaa>Aaa	p.E3908K	DNAH7_ENST00000409063.1_Missense_Mutation_p.E391K	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3908					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCATCACTTCATAGTCAAAC	0.463000													11	80					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739229	55739229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55739229G>A	ENST00000370830.3	-	1	1133	c.435C>T	c.(433-435)ctC>ctT	p.L145L	BMP5_ENST00000446683.2_Silent_p.L145L	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	145					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TGGTATCATGGAGGCTGGCTA	0.453000													22	107					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213872121	213872121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:213872121G>A	ENST00000457361.1	-	8	1712	c.1544C>T	c.(1543-1545)tCa>tTa	p.S515L	IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000451136.2_Missense_Mutation_p.S443L|IKZF2_ENST00000342002.2_Missense_Mutation_p.S521L|IKZF2_ENST00000374327.4_Missense_Mutation_p.S370L|IKZF2_ENST00000421754.2_Missense_Mutation_p.S441L|IKZF2_ENST00000434687.1_Missense_Mutation_p.S515L|IKZF2_ENST00000374319.4_Missense_Mutation_p.S489L	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		AATGTGTGATGAAAACTCATA	0.483000													25	105					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160710199	160710199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160710199C>T	ENST00000263636.4	-	19	2632	c.2605G>A	c.(2605-2607)Gat>Aat	p.D869N	LY75-CD302_ENST00000504764.1_Missense_Mutation_p.D869N|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.D869N|LY75_ENST00000553424.1_Missense_Mutation_p.D869N|LY75_ENST00000554112.1_Missense_Mutation_p.D869N	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TTCTGTCCATCACCAGATATC	0.363000													48	118					0	0	1	0	0
BHMT2	23743	broad.mit.edu	37	5	78376586	78376586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78376586G>A	ENST00000255192.3	+	4	401	c.335G>A	c.(334-336)gGg>gAg	p.G112E	BHMT2_ENST00000521567.1_Intron|DMGDH_ENST00000520388.1_Intron	NM_017614.4	NP_060084.2	Q9H2M3	BHMT2_HUMAN	betaine--homocysteine S-methyltransferase 2	112	Hcy-binding.				methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	15		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	GTAGCAGGGGGGATCTGCCAG	0.453000													35	97					0	0	1	0	0
TSHB	7252	broad.mit.edu	37	1	115576077	115576077	+	Missense_Mutation	SNP	G	G	A	rs121918669		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115576077G>A	ENST00000256592.1	+	2	162	c.94G>A	c.(94-96)Gaa>Aaa	p.E32K	TSHB_ENST00000369517.1_Missense_Mutation_p.E32K	NM_000549.3|NM_001277991.1	NP_000540.2|NP_001264920.1	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta	32					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity	p.E32K(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		AATGCACATCGAAAGGAGAGA	0.423000													42	139					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31302378	31302378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31302378C>T	ENST00000265071.2	+	6	1237	c.972C>T	c.(970-972)acC>acT	p.T324T	CDH6_ENST00000514738.1_Silent_p.T269T	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	324	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ACCAGGAAACCCAGGAAGGGA	0.463000													18	50					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136562369	136562369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136562369C>T	ENST00000264162.2	-	10	4442	c.4432G>A	c.(4432-4434)Gat>Aat	p.D1478N		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1478	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGCAGTGTATCGATGAGCCTC	0.587000													13	34					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38774898	38774898	+	Nonsense_Mutation	SNP	G	G	A	rs145139818	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:38774898G>A	ENST00000308973.4	-	4	2919	c.2314C>T	c.(2314-2316)Cga>Tga	p.R772*	TLR10_ENST00000508334.1_Nonsense_Mutation_p.R772*|TLR10_ENST00000361424.2_Nonsense_Mutation_p.R772*|TLR10_ENST00000506111.1_Nonsense_Mutation_p.R772*	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	772	TIR.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						ATAGCAGCTCGAAGGTTTGCC	0.418000													33	97					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595313	55595313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55595313G>A	ENST00000378397.1	+	1	619	c.619G>A	c.(619-621)Gag>Aag	p.E207K		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				CACTTTGAATGAGAGTGTTAC	0.473000										HNSCC(27;0.073)			60	155					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287329	16287329	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:16287329C>T	ENST00000343518.6	-	1	608	c.557G>A	c.(556-558)tGg>tAg	p.W186*		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	186										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						GACTTTACCCCACCAGGCAGC	0.557000													26	107					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149274851	149274851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149274851G>A	ENST00000255266.5	-	13	1742	c.1623C>T	c.(1621-1623)gcC>gcT	p.A541A		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	541					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ACCGCACCAGGGCCTGTGAAC	0.542000													23	67					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52522226	52522226	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52522226C>T	ENST00000345716.4	+	16	2852	c.2718C>T	c.(2716-2718)atC>atT	p.I906I	NISCH_ENST00000479054.1_Silent_p.I906I	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	906					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CCGCCGCCATCCCCTACTGGC	0.642000													21	68					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735935	41735935	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41735935C>T	ENST00000352645.4	+	10	1189	c.932C>T	c.(931-933)cCt>cTt	p.P311L	ZC3H7B_ENST00000351589.4_Missense_Mutation_p.P311L	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	327					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						GGCTCCATCCCTGTCTCCAGC	0.692000													37	57					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124045738	124045738	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124045738G>C	ENST00000368994.2	+	5	614	c.363G>C	c.(361-363)ctG>ctC	p.L121L	BTBD16_ENST00000260723.4_Silent_p.L120L			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	120										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CACACCCCCTGAGGGAGCTGG	0.602000													35	96					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14852240	14852240	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14852240C>T	ENST00000358984.4	+	36	4120	c.3940C>T	c.(3940-3942)Cga>Tga	p.R1314*		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1399										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TAGGTGGCTTCGACAGCAATT	0.348000													3	4					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111936872	111936872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111936872C>T	ENST00000374566.3	-	26	3182	c.2665G>A	c.(2665-2667)Gag>Aag	p.E889K		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	889						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ATCATCTTCTCTCTCTCCAGT	0.448000													5	53					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42718224	42718224	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:42718224G>A	ENST00000230882.4	+	9	1135		c.e9+1		GHR_ENST00000357703.3_Splice_Site|GHR_ENST00000513625.1_Splice_Site|GHR_ENST00000537449.1_Splice_Site	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor						2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TCTCCTCAAGGTAACTAATAA	0.328000													29	66					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71549884	71549884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71549884C>T	ENST00000265382.3	+	13	1585	c.1280C>T	c.(1279-1281)tCa>tTa	p.S427L	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.S427L	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	427						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		ATTGTGTCCTCAATTAGCCAG	0.433000													20	73					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182780880	182780880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182780880C>T	ENST00000431877.2	+	11	2692	c.2513C>T	c.(2512-2514)cCa>cTa	p.P838L	SSFA2_ENST00000320370.7_Missense_Mutation_p.P838L|SSFA2_ENST00000428267.2_Missense_Mutation_p.P685L|SSFA2_ENST00000409136.1_Missense_Mutation_p.P347L|SSFA2_ENST00000409001.1_Missense_Mutation_p.P838L	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	838						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			GCTCCACCACCAATGTCTCAG	0.547000													32	98					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6521698	6521698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6521698G>A	ENST00000377782.3	-	10	1144	c.1077C>T	c.(1075-1077)ttC>ttT	p.F359F	TNFRSF25_ENST00000356876.3_Silent_p.F350F|TNFRSF25_ENST00000351748.3_Silent_p.F167F|TNFRSF25_ENST00000348333.3_Silent_p.F305F|TNFRSF25_ENST00000351959.5_Silent_p.F313F	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	350	Death.				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GCGTGCGCACGAACTCCTTCC	0.697000													7	21					0	0	1	0	0
SLC25A24	29957	broad.mit.edu	37	1	108735132	108735132	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:108735132G>A	ENST00000370041.4	-	1	308	c.112C>T	c.(112-114)Cta>Tta	p.L38L	SLC25A24_ENST00000565488.1_Intron	NM_213651.2	NP_998816.1	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	57	EF-hand 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		GCTTCCTCTAGAGATTGAATG	0.522000													108	238					0	0	1	0	0
SULT1E1	6783	broad.mit.edu	37	4	70713498	70713498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70713498G>A	ENST00000226444.3	-	6	621	c.509C>T	c.(508-510)tCc>tTc	p.S170F		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	170					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						TTTATACCAGGAACCATAAGG	0.368000													25	83					0	0	1	0	0
GJC3	349149	broad.mit.edu	37	7	99526588	99526588	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99526588C>T	ENST00000312891.2	-	1	655	c.656G>A	c.(655-657)tGg>tAg	p.W219*		NM_181538.2	NP_853516.1	Q8NFK1	CXG3_HUMAN	gap junction protein, gamma 3, 30.2kDa	219						connexon complex|integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CCAGGTCCTCCACCATCTCCC	0.458000													24	53					0	0	1	0	0
GFI1	2672	broad.mit.edu	37	1	92948963	92948963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92948963G>A	ENST00000370332.1	-	2	400	c.82C>T	c.(82-84)Cgt>Tgt	p.R28C	GFI1_ENST00000294702.5_Missense_Mutation_p.R28C|GFI1_ENST00000483490.1_5'UTR|GFI1_ENST00000427103.1_Missense_Mutation_p.R28C	NM_001127215.1	NP_001120687.1	Q99684	GFI1_HUMAN	growth factor independent 1 transcription repressor	28					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		TTCTCTAAACGGAGGGAATAG	0.647000													4	26					0	0	1	0	0
MFAP3L	9848	broad.mit.edu	37	4	170912825	170912825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:170912825G>A	ENST00000361618.3	-	3	1241	c.934C>T	c.(934-936)Cct>Tct	p.P312S	RP11-6E9.4_ENST00000508955.1_RNA|MFAP3L_ENST00000393704.3_Missense_Mutation_p.P209S	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	312						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		ATTTGCTGAGGTTGCTCGTGC	0.552000													5	49					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197404312	197404312	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197404312C>T	ENST00000367397.1	+	5	2320	c.1462C>T	c.(1462-1464)Ctc>Ttc	p.L488F	CRB1_ENST00000544212.1_Missense_Mutation_p.L588F|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.L995F|CRB1_ENST00000535699.1_Missense_Mutation_p.L1083F|CRB1_ENST00000367400.3_Missense_Mutation_p.L1107F			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1107	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGGCATTTATCTCTCTTACTT	0.368000													28	97					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41496173	41496173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41496173C>T	ENST00000400454.1	-	20	4122	c.3645G>A	c.(3643-3645)ctG>ctA	p.L1215L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1215	Fibronectin type-III 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGATGCCGTTCAGCTTGAGAG	0.567000													23	156					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117691541	117691541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117691541G>A	ENST00000317775.6	-	17	3235	c.2550C>T	c.(2548-2550)ttC>ttT	p.F850F	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.F884F	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	850	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGACGCTGTTGAATCGGACCT	0.542000													10	69					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284448	159284448	+	Splice_Site	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159284448A>C	ENST00000332217.5	-	1	1	c.0_splice	c.e1-1	p.M1_splice		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					TAGCTTTGGCATCAAGGTAGG	0.423000													40	173					0	0	1	0	0
KRT39	390792	broad.mit.edu	37	17	39118816	39118816	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39118816C>T	ENST00000355612.2	-	4	744		c.e4-1		AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39							intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				AATTGATTTCCTAAGGAAAGA	0.403000													34	73					0	0	1	0	0
UPK3B	80761	broad.mit.edu	37	7	76140314	76140314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76140314C>T	ENST00000419923.2	+	1	570	c.345C>T	c.(343-345)ttC>ttT	p.F115F	UPK3B_ENST00000334348.3_Silent_p.F60F|UPK3B_ENST00000448265.3_Silent_p.F115F|UPK3B_ENST00000257632.5_Silent_p.F115F|UPK3B_ENST00000443097.2_Silent_p.F60F|UPK3B_ENST00000394849.1_Silent_p.F60F			Q9BT76	UPK3B_HUMAN	uroplakin 3B	115					negative regulation of gene expression	integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(1)|skin(2)	8		Myeloproliferative disorder(862;0.204)				GCTGTGTCTTCGATGGGCTTG	0.632000													5	4					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130504133	130504133	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130504133C>T	ENST00000314830.8	-	9	2135	c.2022G>A	c.(2020-2022)gaG>gaA	p.E674E	SH2D3C_ENST00000420366.1_Silent_p.E516E|SH2D3C_ENST00000373274.3_Silent_p.E514E|SH2D3C_ENST00000373276.3_Silent_p.E606E|SH2D3C_ENST00000373277.4_Silent_p.E517E|SH2D3C_ENST00000429553.1_Silent_p.E320E	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	674	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCCCCCGCAGCTCGGCCGCCA	0.662000													27	42					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118147626	118147626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:118147626C>T	ENST00000456015.2	+	1	60	c.60C>T	c.(58-60)ttC>ttT	p.F20F	SLC30A8_ENST00000521243.1_Intron|SLC30A8_ENST00000427715.2_5'UTR|SLC30A8_ENST00000521035.1_3'UTR|SLC30A8_ENST00000519688.1_5'UTR	NM_173851.2	NP_776250.2	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	20					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TGTATGCTTTCACACTAGAAA	0.403000													40	152					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219884425	219884425	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219884425C>T	ENST00000341552.5	-	20	3359	c.3276G>A	c.(3274-3276)gaG>gaA	p.E1092E	CCDC108_ENST00000453220.1_Silent_p.E1092E|CCDC108_ENST00000441968.1_Silent_p.E1092E	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1092						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTCCTGCTTCTCCCCAGCCT	0.622000													6	27					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21876620	21876620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21876620G>A	ENST00000399982.2	-	12	2645	c.2581C>T	c.(2581-2583)Ccc>Tcc	p.P861S	CHD8_ENST00000430710.3_Missense_Mutation_p.P582S|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000557364.1_Missense_Mutation_p.P861S	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	861	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ACCAAGAAGGGACCATGGATG	0.468000													11	76					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012823	29012823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29012823C>T	ENST00000377175.1	-	1	194	c.130G>A	c.(130-132)Gcc>Acc	p.A44T		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						AGAATGATGGCTGTGTTACCC	0.403000													48	102					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616431	248616431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248616431G>A	ENST00000342927.3	+	1	355	c.333G>A	c.(331-333)ggG>ggA	p.G111G		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGATTGGAGGGGAATTCTTCC	0.542000													45	244					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10032366	10032366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:10032366C>T	ENST00000378380.3	+	7	2028	c.1699C>T	c.(1699-1701)Cat>Tat	p.H567Y	ANKEF1_ENST00000488991.1_3'UTR|ANKEF1_ENST00000378392.1_Missense_Mutation_p.H567Y|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000603542.1_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		TTTTGCATGCCATGCAGGCCA	0.368000													18	68					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19070842	19070842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19070842C>T	ENST00000569532.1	+	15	2262	c.2132C>T	c.(2131-2133)tCa>tTa	p.S711L	TMC7_ENST00000421369.3_Intron|TMC7_ENST00000304381.5_Intron			Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	0						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						TCCAGAGGGTCATGGCTGGGG	0.517000													22	48					0	0	1	0	0
PIK3R1	5295	broad.mit.edu	37	5	67576471	67576471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:67576471C>T	ENST00000521381.1	+	6	1366	c.750C>T	c.(748-750)ctC>ctT	p.L250L	PIK3R1_ENST00000396611.1_Silent_p.L250L|PIK3R1_ENST00000274335.5_Silent_p.L250L|PIK3R1_ENST00000521657.1_Silent_p.L250L	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	250	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TCTTCAAGCTCTCTCAAACCT	0.388000			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			55	151					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104472813	104472813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104472813C>T	ENST00000409874.4	+	16	1849	c.1801C>T	c.(1801-1803)Ctt>Ttt	p.L601F	TDRD9_ENST00000339063.5_Missense_Mutation_p.L601F	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	601					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				TTTAGCCCAACTTCCTGTAAA	0.378000													28	64					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36117840	36117840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36117840G>A	ENST00000296603.4	-	10	1761	c.1299C>T	c.(1297-1299)atC>atT	p.I433I		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	433						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AACTGACCTCGATATAAATAT	0.333000													14	24					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59189838	59189838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59189838C>T	ENST00000302040.4	-	1	611	c.589G>A	c.(589-591)Gag>Aag	p.E197K		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						GTCACCACCTCGCTGGTGAAG	0.478000													32	46					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11344004	11344004	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11344004G>A	ENST00000294618.7	-	22	2604	c.2593C>T	c.(2593-2595)Cgt>Tgt	p.R865C	DOCK6_ENST00000319867.7_Missense_Mutation_p.R169C	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	865					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CCAGAGCCACGGGCCAGTGTG	0.642000													11	30					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7329010	7329010	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7329010G>A	ENST00000333870.3	+	1	77	c.3G>A	c.(1-3)atG>atA	p.M1I	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Start_Codon_SNP_p.M1I	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	1						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				CCCCCTCCATGGAAAACCAGC	0.607000													7	62					0	0	1	0	0
ODF1	4956	broad.mit.edu	37	8	103564014	103564014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:103564014G>A	ENST00000285402.3	+	1	215	c.59G>A	c.(58-60)aGa>aAa	p.R20K		NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	20					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			AAGGTGGACAGAGAACTAAGG	0.483000													14	119					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207564458	207564458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207564458C>T	ENST00000452335.2	-	7	828	c.712G>A	c.(712-714)Gga>Aga	p.G238R	DYTN_ENST00000477734.1_5'UTR	NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	238						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TACCTGAGTCCCGTGATTGGG	0.527000													4	42					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128478853	128478853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128478853G>A	ENST00000325888.8	+	8	1668	c.1407G>A	c.(1405-1407)tcG>tcA	p.S469S	FLNC_ENST00000346177.6_Silent_p.S469S	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	469					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TCCATGTGTCGGAAGGTAAGG	0.637000													30	60					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013088	107013088	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107013088G>A	ENST00000390625.2	-	0	286																											TGCTTCTAATGAAACCTACCC	0.507000													40	99					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101018320	101018320	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101018320T>A	ENST00000360863.6	-	16	2573	c.2379A>T	c.(2377-2379)gaA>gaT	p.E793D	RGS22_ENST00000523437.1_Missense_Mutation_p.E781D|RGS22_ENST00000519421.1_5'UTR|RGS22_ENST00000523287.1_Missense_Mutation_p.E612D	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	793					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ACTGTCGAGTTTCTTCCACCA	0.373000													18	47					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66254783	66254783	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66254783C>T	ENST00000532677.1	+	5	1001	c.600C>T	c.(598-600)gcC>gcT	p.A200A	DPP3_ENST00000541961.1_Silent_p.A181A|DPP3_ENST00000531863.1_Silent_p.A201A|DPP3_ENST00000360510.2_Silent_p.A181A|DPP3_ENST00000530165.1_Silent_p.A151A|DPP3_ENST00000453114.1_Silent_p.A181A	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	181					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TGGAAGATGCCAAATTGGCCC	0.542000													20	62					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56030715	56030715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56030715C>T	ENST00000309675.2	+	1	72	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						TGAATTCCTCCTTCTGGGATT	0.522000													42	88					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1441598	1441598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1441598G>A	ENST00000270349.9	-	3	421	c.294C>T	c.(292-294)ttC>ttT	p.F98F	SLC6A3_ENST00000453492.2_Silent_p.F98F	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	98					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGGGGACCAGGAAGGCACCTG	0.597000													13	36					0	0	1	0	0
TMEM61	199964	broad.mit.edu	37	1	55457675	55457675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55457675G>A	ENST00000371268.3	+	3	806	c.532G>A	c.(532-534)Gag>Aag	p.E178K	RP11-12C17.2_ENST00000436960.1_RNA	NM_182532.1	NP_872338.1	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	178						integral to membrane				endometrium(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	4						ACCCAGCTATGAGAGCATCAG	0.622000													17	131					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179520386	179520386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179520386C>T	ENST00000367615.4	-	8	1142	c.1074G>A	c.(1072-1074)caG>caA	p.Q358Q	AXDND1_ENST00000367618.3_Intron|NPHS2_ENST00000367616.4_Silent_p.Q290Q	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	358					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GGAGGCTTCCCTGAGTTCTGT	0.478000													34	92					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953566	140953566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140953566G>A	ENST00000277549.5	+	31	4666	c.2097G>A	c.(2095-2097)ctG>ctA	p.L699L	CACNA1B_ENST00000371357.1_Silent_p.L1504L|CACNA1B_ENST00000371363.1_Silent_p.L1503L|CACNA1B_ENST00000277551.2_Silent_p.L1503L|CACNA1B_ENST00000371355.4_Silent_p.L1504L|CACNA1B_ENST00000371372.1_Silent_p.L1503L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1503					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGCTGATGCTGAAATGCCTGA	0.542000													6	18					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39782184	39782184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:39782184C>T	ENST00000564288.1	+	28	4348	c.3571C>T	c.(3571-3573)Cat>Tat	p.H1191Y	MACF1_ENST00000545844.1_Missense_Mutation_p.H1196Y|MACF1_ENST00000539005.1_Missense_Mutation_p.H1196Y|MACF1_ENST00000372915.3_Missense_Mutation_p.H1196Y|MACF1_ENST00000361689.2_Missense_Mutation_p.H1196Y|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000317713.7_Missense_Mutation_p.H1196Y|MACF1_ENST00000567887.1_Missense_Mutation_p.H1228Y			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	1196					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCTGGAGGCCCATTGGTCGAC	0.443000													43	120					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144995895	144995895	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144995895G>A	ENST00000322810.4	-	32	8674	c.8505C>T	c.(8503-8505)atC>atT	p.I2835I	PLEC_ENST00000356346.3_Silent_p.I2684I|PLEC_ENST00000357649.2_Silent_p.I2702I|PLEC_ENST00000436759.2_Silent_p.I2725I|PLEC_ENST00000527096.1_Silent_p.I2721I|PLEC_ENST00000398774.2_Silent_p.I2666I|PLEC_ENST00000345136.3_Silent_p.I2698I|PLEC_ENST00000354589.3_Silent_p.I2698I|PLEC_ENST00000354958.2_Silent_p.I2676I	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2835	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ACAGCCCTGCGATACTGCTGC	0.672000													11	42					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36130328	36130328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36130328G>A	ENST00000303965.4	-	21	3956	c.3467C>T	c.(3466-3468)cCt>cTt	p.P1156L		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1156	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TATATGCAAAGGATCACCATT	0.328000													16	55					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2436319	2436319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2436319C>T	ENST00000419816.2	+	22	4192	c.3918C>T	c.(3916-3918)ctC>ctT	p.L1306L	PLCH2_ENST00000378488.3_Silent_p.L1270L|PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000449969.1_3'UTR|PLCH2_ENST00000378486.3_Silent_p.L1306L			O75038	PLCH2_HUMAN	phospholipase C, eta 2	1306					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TGCGCTGGCTCACTGTCTTCC	0.711000													7	9					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110882722	110882722	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110882722A>G	ENST00000369784.3	+	1	1595	c.695A>G	c.(694-696)aAg>aGg	p.K232R	RBM15_ENST00000487146.2_Missense_Mutation_p.K232R|RBM15_ENST00000602849.1_Missense_Mutation_p.K232R	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	232	RRM 1.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGGGCGGCCAAGCATGCCAGA	0.597000			T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	73					0	0	1	0	0
PCIF1	63935	broad.mit.edu	37	20	44569769	44569769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44569769C>T	ENST00000372409.3	+	7	960	c.596C>T	c.(595-597)cCc>cTc	p.P199L		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	199						nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						CCCCCGCATCCCGAAGTGGAA	0.622000													18	45					0	0	1	0	0
BEST4	266675	broad.mit.edu	37	1	45250845	45250845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:45250845C>T	ENST00000372207.3	-	6	846	c.847G>A	c.(847-849)Gac>Aac	p.D283N		NM_153274.2	NP_695006.1	Q8NFU0	BEST4_HUMAN	bestrophin 4	283						chloride channel complex|plasma membrane	chloride channel activity			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)					ATGTCCGGGTCTCCCAGGGCT	0.627000													18	80					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40191557	40191557	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:40191557C>T	ENST00000360214.3	+	9	1402	c.942C>T	c.(940-942)ttC>ttT	p.F314F	ETS2_ENST00000360938.3_Silent_p.F314F	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	314					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TCGAGAGCTTCGAAGATGACT	0.547000													14	34					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	97990571	97990571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97990571C>T	ENST00000224337.5	-	4	324	c.183G>A	c.(181-183)gaG>gaA	p.E61E	BLNK_ENST00000371176.2_Silent_p.E61E|BLNK_ENST00000413476.2_Silent_p.E61E|BLNK_ENST00000427367.2_Silent_p.E61E	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	61					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ACCACTGCTCCTCTTCGTCAG	0.542000													4	13					0	0	1	0	0
IGHV3-33	28434	broad.mit.edu	37	14	106815979	106815979	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106815979G>A	ENST00000390615.2	-	0	173																											CTCCCAGGCTGGACCACGCCT	0.577000													19	76					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6948775	6948775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:6948775C>T	ENST00000383032.1	+	14	1605	c.958C>T	c.(958-960)Ccc>Tcc	p.P320S	TBL1Y_ENST00000346432.3_Missense_Mutation_p.P320S|TBL1Y_ENST00000355162.2_Missense_Mutation_p.P320S	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	320					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						TGCTGCAGCCCCCGCCCTTGA	0.507000													28	21					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9018484	9018484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9018484G>A	ENST00000397910.4	-	24	37893	c.37690C>T	c.(37690-37692)Cct>Tct	p.P12564S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12566	SEA 4.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGGAGCCAGGGCGATGCATG	0.542000													49	151					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154158558	154158558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:154158558C>T	ENST00000360256.4	-	14	3707	c.3507G>A	c.(3505-3507)gtG>gtA	p.V1169V		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1169	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCCTACTACCACTTTGTTTT	0.403000													54	31					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474538	140474538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140474538G>A	ENST00000194155.4	+	1	312	c.164G>A	c.(163-165)gGg>gAg	p.G55E		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		55	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAGACCTGGGGCTGGAGATA	0.512000													14	64					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62739945	62739945	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62739945G>A	ENST00000371153.4	-	3	1209	c.831C>T	c.(829-831)ttC>ttT	p.F277F	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	277	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						AGCCAGGGGTGAACAACACCT	0.542000													13	15					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32954042	32954042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:32954042C>T	ENST00000321639.5	+	3	1022	c.694C>T	c.(694-696)Ccc>Tcc	p.P232S		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	232						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CTCCTCCTCGCCCTCCAGCCC	0.597000													13	49					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659194	196659194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196659194G>A	ENST00000312428.6	-	57	10684	c.10584C>T	c.(10582-10584)ttC>ttT	p.F3528F	DNAH7_ENST00000409063.1_Silent_p.F11F	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3528	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTGACACAGGGAAATTTGGAG	0.418000													41	98					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119027100	119027100	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119027100G>A	ENST00000307417.3	+	7	1112	c.748G>A	c.(748-750)Ggc>Agc	p.G250S	ABCG4_ENST00000531739.1_Missense_Mutation_p.G250S|ABCG4_ENST00000449422.2_Missense_Mutation_p.G250S	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	250	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGCACAGGGGGGCCGTACCAT	0.587000													66	163					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885060	29885060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29885060G>A	ENST00000310624.6	+	4	1464	c.1431G>A	c.(1429-1431)gaG>gaA	p.E477E		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	477	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						aggagaaagaggccaaagagg	0.507000													13	20					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25281188	25281188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25281188G>A	ENST00000218548.6	+	16	2548	c.2215G>A	c.(2215-2217)Gga>Aga	p.G739R	ATP12A_ENST00000381946.3_Missense_Mutation_p.G733R	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	733					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GACCGGGGATGGAGTTAATGA	0.557000													14	46					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37325588	37325588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:37325588G>A	ENST00000373091.3	-	6	833	c.817C>T	c.(817-819)Cgc>Tgc	p.R273C	GRIK3_ENST00000373093.4_Missense_Mutation_p.R273C	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	273					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCTGAGTAGCGGTAGGGCTCC	0.572000													17	73					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44685809	44685809	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44685809G>A	ENST00000454036.1	+	25	3271	c.3194_splice	c.e25-1	p.L1065_splice	SLC12A5_ENST00000243964.3_Splice_Site_p.L1042_splice	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	1065					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCTGCCGCAGGAACCAGTCCA	0.632000													11	62					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66937361	66937361	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:66937361C>T	ENST00000374690.3	+	5	2739	c.2215C>T	c.(2215-2217)Cag>Tag	p.Q739*	AR_ENST00000396044.3_Intron|AR_ENST00000396043.2_Nonsense_Mutation_p.Q207*	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	738	Interaction with MYST2.|Ligand-binding.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GGCTGTCATTCAGTACTCCTG	0.542000									Androgen Insensitivity Syndrome				17	13					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219664	67219664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67219664C>T	ENST00000312457.2	-	1	536	c.532G>A	c.(532-534)Gac>Aac	p.D178N		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	178						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			ATGACCAGGTCGTACCACCAG	0.662000													42	74					0	0	1	0	0
KRT34	3885	broad.mit.edu	37	17	39538306	39538306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39538306C>T	ENST00000394001.1	-	1	349	c.319G>A	c.(319-321)Gac>Aac	p.D107N		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	107	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				GCCAGGCGGTCGTTCAGGAAC	0.612000													17	109					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595213	55595213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55595213G>A	ENST00000378397.1	+	1	519	c.519G>A	c.(517-519)gtG>gtA	p.V173V		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V173V(1)		breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				GATCTAATGTGATTAACCACT	0.478000										HNSCC(27;0.073)			78	227					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147040970	147040970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147040970C>T	ENST00000265272.5	-	3	635	c.168G>A	c.(166-168)aaG>aaA	p.K56K	JAKMIP2_ENST00000507386.1_Silent_p.K56K|JAKMIP2_ENST00000333010.6_Silent_p.K14K	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	56						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGAATCCTCTTCGCTTCTT	0.507000													55	116					0	0	1	0	0
PCSK7	9159	broad.mit.edu	37	11	117100449	117100449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117100449G>A	ENST00000320934.3	-	3	742	c.112C>T	c.(112-114)Ctg>Ttg	p.L38L		NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	38					peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		GTCCCTGCCAGGCCCATGACC	0.652000			T	IGH@	MLCLS								11	29					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671187	31671187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31671187C>T	ENST00000375483.3	+	3	184	c.184C>T	c.(184-186)Ccc>Tcc	p.P62S		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	62						cytoplasm|extracellular region	lipid binding										TGGTGATATTCCCTACAATGA	0.507000													39	122					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177225145	177225145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177225145G>A	ENST00000361539.4	+	3	672	c.360G>A	c.(358-360)cgG>cgA	p.R120R		NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		120						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AGTTTATCCGGAACATTCGCC	0.483000											OREG0014006	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	79					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99661607	99661607	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:99661607G>A	ENST00000373034.4	-	1	3664	c.1989C>T	c.(1987-1989)tcC>tcT	p.S663S	PCDH19_ENST00000255531.7_Silent_p.S663S|PCDH19_ENST00000420881.2_Silent_p.S663S	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	663	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CGAGAGCAGGGGACAAGTAGA	0.522000													6	14					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1096345	1096345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1096345G>A	ENST00000441003.2	+	34	6397	c.6370G>A	c.(6370-6372)Gac>Aac	p.D2124N	MUC2_ENST00000361558.6_Missense_Mutation_p.D262N|MUC2_ENST00000333592.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4486						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGGCTGGGGCGACCCGCACTA	0.662000													10	38					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731166	21731166	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:21731166C>T	ENST00000584755.1	+	2	865	c.468C>T	c.(466-468)ttC>ttT	p.F156F	UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Silent_p.F156F|UBBP4_ENST00000583708.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						TGCAGATCTTCGTGAAGACCC	0.537000													28	34					0	0	1	0	0
DENND6A	201627	broad.mit.edu	37	3	57631445	57631445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:57631445G>A	ENST00000311128.5	-	11	1050	c.980C>T	c.(979-981)cCt>cTt	p.P327L	RP11-755B10.2_ENST00000470427.1_RNA	NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		AGTGAAATAAGGTCGGAAATC	0.338000													8	96					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11732253	11732253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:11732253C>T	ENST00000304623.8	-	2	358	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K	CTNND2_ENST00000458100.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.E57K	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	57					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TCTACCTGTTCTTTGACTGAG	0.418000													12	137					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16032807	16032807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16032807G>A	ENST00000350896.3	-	3	303	c.106C>T	c.(106-108)Cct>Tct	p.P36S	MSR1_ENST00000381998.4_Missense_Mutation_p.P36S|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000262101.5_Missense_Mutation_p.P36S|MSR1_ENST00000445506.2_Missense_Mutation_p.P54S|MSR1_ENST00000355282.2_Missense_Mutation_p.P36S	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	36					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CTGTTTTTAGGATCTAATAAA	0.388000													11	56					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30934539	30934539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30934539C>T	ENST00000355537.3	+	2	217	c.70C>T	c.(70-72)Ccc>Tcc	p.P24S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCTGAGTGGCCCCGTCCTCAA	0.622000													45	135					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67223019	67223019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67223019G>A	ENST00000314586.6	-	3	351	c.111C>T	c.(109-111)gcC>gcT	p.A37A	EXOC3L1_ENST00000562887.1_5'UTR	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	37	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						AGATGCCTGAGGCCCACTTGA	0.682000													5	14					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45945569	45945569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45945569C>T	ENST00000323084.4	-	8	1368	c.1303G>A	c.(1303-1305)Gag>Aag	p.E435K	C21orf90_ENST00000465978.1_Intron|TSPEAR_ENST00000397916.1_Missense_Mutation_p.E367K	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	435					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						AGGAAGTGCTCCCCATCCACC	0.592000													53	128					0	0	1	0	0
ADI1	55256	broad.mit.edu	37	2	3504690	3504690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:3504690G>A	ENST00000382093.5	-	3	3134	c.297C>T	c.(295-297)ttC>ttT	p.F99F	ADI1_ENST00000327435.6_Silent_p.F105F			Q9BV57	MTND_HUMAN	acireductone dioxygenase 1	105					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus|plasma membrane	acireductone dioxygenase (Ni2+-requiring) activity|metal ion binding|protein binding			breast(2)|large_intestine(2)|lung(4)|ovary(1)|stomach(1)	10	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0729)|Epithelial(75;0.173)|all cancers(51;0.228)		CCCTCACATCGAAGTACCCAC	0.537000													14	60					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50731719	50731719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:50731719C>T	ENST00000442544.2	+	10	2323	c.1707C>T	c.(1705-1707)tcC>tcT	p.S569S	DCC_ENST00000581580.1_Silent_p.S224S|DCC_ENST00000412726.1_Silent_p.S417S	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	569	Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTGAGGTGTCCACAGGAAAAG	0.473000													44	144					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81236166	81236166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81236166G>A	ENST00000599697.1	-	6	1081	c.1082C>T	c.(1081-1083)cCt>cTt	p.P361L	PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000337114.4_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	361					neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CTGGCAGAGAGGGCCGGCTCC	0.567000													12	88					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55961753	55961753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55961753G>A	ENST00000263923.4	-	20	3103	c.2808C>T	c.(2806-2808)gtC>gtT	p.V936V		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	936	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCTTGTAGGGGACAAATTCAT	0.423000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			22	64					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181732562	181732562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181732562C>T	ENST00000526775.1	+	33	4818	c.4653C>T	c.(4651-4653)ttC>ttT	p.F1551F	CACNA1E_ENST00000367570.1_Silent_p.F1570F|CACNA1E_ENST00000367567.4_Silent_p.F1177F|CACNA1E_ENST00000360108.3_Silent_p.F1551F|CACNA1E_ENST00000357570.5_Silent_p.F1521F|CACNA1E_ENST00000358338.5_Silent_p.F1502F|CACNA1E_ENST00000367573.2_Silent_p.F1570F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1570					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCAGTGGCTTCAATATGAGCT	0.433000													7	79					0	0	1	0	0
CHRM1	1128	broad.mit.edu	37	11	62677545	62677545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62677545G>A	ENST00000306960.3	-	2	1569	c.1028C>T	c.(1027-1029)cCc>cTc	p.P343L	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	343					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	CTTTCCACGGGGCTTCTGGCC	0.627000													14	41					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65500011	65500011	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65500011C>T	ENST00000261883.4	-	3	319	c.154_splice	c.e3+1	p.E51_splice		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	51					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						ACAACTCACTCTCCAGGGTGT	0.592000													27	25					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27167664	27167664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27167664C>T	ENST00000288699.6	+	12	1739	c.1581C>T	c.(1579-1581)gaC>gaT	p.D527D	DPYSL5_ENST00000401478.1_Silent_p.D527D	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	527					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCATGAGGGACCTTCACGAAT	0.622000													28	69					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55362421	55362421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:55362421C>T	ENST00000536015.1	-	10	1041	c.922G>A	c.(922-924)Ggc>Agc	p.G308S	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.G308S|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	308			G -> D (in BRIC1; dbSNP:rs28939685).|G -> V (in PFIC1; dbSNP:rs28939685).		ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				ATGACTAAGCCGTGGCAGAAA	0.383000													29	57					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75708675	75708675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75708675C>T	ENST00000370855.5	-	8	480	c.367G>A	c.(367-369)Gaa>Aaa	p.E123K	SLC44A5_ENST00000370859.3_Missense_Mutation_p.E123K|SLC44A5_ENST00000535611.1_5'UTR|SLC44A5_ENST00000469525.1_5'UTR	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	123						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						AAAAATTTTTCTGGGCACTTG	0.398000													7	106					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711218	140711218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140711218G>A	ENST00000517417.1	+	1	967	c.967G>A	c.(967-969)Gat>Aat	p.D323N	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.D323N	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAAGCCCAGGATGGTGCGGG	0.393000													25	73					0	0	1	0	0
MAN1A1	4121	broad.mit.edu	37	6	119623257	119623257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:119623257C>T	ENST00000368468.3	-	4	1153	c.712G>A	c.(712-714)Gga>Aga	p.G238R	MAN1A1_ENST00000368466.2_Missense_Mutation_p.G261R	NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	238					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		ATAGTTGCTCCTTTGATGTTA	0.289000													7	15					0	0	1	0	0
MIR31HG	554202	broad.mit.edu	37	9	21455665	21455665	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21455665C>A	ENST00000304425.3	-	0	720					NR_027054.1																						ACTTCAGATTCCCCCAGGAGA	0.502000													10	14					7.48243e-07	7.50068e-07	1	1	0
OR2L3	391192	broad.mit.edu	37	1	248224134	248224134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248224134G>A	ENST00000359959.3	+	1	151	c.151G>A	c.(151-153)Gac>Aac	p.D51N	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CATCTTCTTGGACACCCATCT	0.413000													159	416					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73479976	73479976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73479976G>A	ENST00000523207.1	+	2	595	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	3					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CAAAATGGCAGAAAAGGCTCC	0.512000													42	90					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952916	54952916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54952916C>T	ENST00000273286.5	-	3	770	c.608G>A	c.(607-609)gGa>gAa	p.G203E	CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.G127E|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	203	LRRCT.					integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		GTCTGTTAGTCCCCCTTTAAA	0.453000													5	38					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151835975	151835975	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151835975G>A	ENST00000355193.2	-	59	14938	c.14720C>T	c.(14719-14721)tCg>tTg	p.S4907L	KMT2C_ENST00000262189.6_Missense_Mutation_p.S4850L|KMT2C_ENST00000485655.2_Missense_Mutation_p.S55L					lysine (K)-specific methyltransferase 2C																		AGGTGCACACGAATGGTTGAT	0.398000													32	118					0	0	1	0	0
PDK2	5164	broad.mit.edu	37	17	48182768	48182768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48182768C>T	ENST00000503176.1	+	3	455	c.294C>T	c.(292-294)ttC>ttT	p.F98F	PDK2_ENST00000007708.3_Silent_p.F34F	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	98					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						TCATGGAGTTCCTGGACAAGG	0.637000									Autosomal Dominant Polycystic Kidney Disease				10	23					0	0	1	0	0
PAOX	196743	broad.mit.edu	37	10	135193892	135193892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:135193892G>A	ENST00000278060.5	+	2	654	c.571G>A	c.(571-573)Gaa>Aaa	p.E191K	PAOX_ENST00000368539.4_Intron|PAOX_ENST00000480071.2_Missense_Mutation_p.E191K|PAOX_ENST00000357296.3_Missense_Mutation_p.E191K|PAOX_ENST00000368535.2_3'UTR	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	329					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		CTTCAACCTGGAATGCTGTGT	0.597000													8	36					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8602908	8602908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8602908C>T	ENST00000360986.4	+	3	354	c.180C>T	c.(178-180)acC>acT	p.T60T	CPZ_ENST00000506287.1_3'UTR|CPZ_ENST00000382480.2_5'UTR|CPZ_ENST00000315782.6_Silent_p.T49T	NM_001014447.2	NP_001014447.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	60	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACCACACCACCTTCCCCAACC	0.642000													16	49					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128489559	128489559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128489559C>T	ENST00000325888.8	+	30	5387	c.5126C>T	c.(5125-5127)cCc>cTc	p.P1709L	FLNC_ENST00000346177.6_Missense_Mutation_p.P1709L	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1709					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TACACAGCGCCCGAGCCGGGC	0.582000													25	42					0	0	1	0	0
CDSN	1041	broad.mit.edu	37	6	31084467	31084467	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31084467G>A	ENST00000376288.2	-	2	951	c.925C>T	c.(925-927)Cca>Tca	p.P309S	PSORS1C1_ENST00000259881.9_Intron|PSORS1C1_ENST00000467107.1_3'UTR	NM_001264.4	NP_001255.3	Q15517	CDSN_HUMAN	corneodesmosin	309	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)	10						GTCATGCCTGGAACCAGATAA	0.547000													6	61					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233388106	233388106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233388106C>T	ENST00000258229.8	-	7	2356	c.2122G>A	c.(2122-2124)Gaa>Aaa	p.E708K	PCNXL2_ENST00000430153.1_Missense_Mutation_p.E7K	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	708						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TCACCATGTTCATCAATGAAG	0.418000													18	54					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179535872	179535872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179535872G>A	ENST00000589042.1	-	156	35477	c.35253C>T	c.(35251-35253)atC>atT	p.I11751I	TTN_ENST00000342992.6_Silent_p.I10450I|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.I11377I|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9869	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTGGAGGGATGATTTTCT	0.353000													14	37					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64824920	64824920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64824920C>T	ENST00000358658.3	-	4	553	c.526G>A	c.(526-528)Gag>Aag	p.E176K	NAALADL1_ENST00000339885.2_Missense_Mutation_p.E176K|NAALADL1_ENST00000355721.3_Intron|NAALADL1_ENST00000356632.3_Missense_Mutation_p.E176K|NAALADL1_ENST00000355369.2_Missense_Mutation_p.E176K|NAALADL1_ENST00000340252.4_Missense_Mutation_p.E176K	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	176					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						GTCTGTAGCTCCTTAAAGTCT	0.607000													22	49					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32752501	32752501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32752501C>T	ENST00000380250.3	+	21	3105	c.2609C>T	c.(2608-2610)cCc>cTc	p.P870L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AAGCACTGCCCCACAGCCCTC	0.562000													47	139					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21033937	21033937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21033937G>A	ENST00000381545.3	+	12	1699	c.1480G>A	c.(1480-1482)Ggt>Agt	p.G494S	SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000540229.1_Missense_Mutation_p.G494S|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G494S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.G494S	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	494	Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATCCTCAAGTGGTATTAAAAA	0.358000													47	119					0	0	1	0	0
GFRA2	2675	broad.mit.edu	37	8	21563492	21563492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:21563492G>A	ENST00000524240.1	-	5	1506	c.856C>T	c.(856-858)Cct>Tct	p.P286S	GFRA2_ENST00000517328.1_Missense_Mutation_p.P286S|GFRA2_ENST00000518077.1_Missense_Mutation_p.P153S|GFRA2_ENST00000400782.4_Missense_Mutation_p.P181S	NM_001495.4	NP_001486.4	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2	286						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|prostate(1)|skin(1)	7				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		TTGTCCGCAGGGCAGCTGGTG	0.587000													4	7					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39579060	39579060	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39579060C>T	ENST00000225550.3	-	3	701	c.702G>A	c.(700-702)gaG>gaA	p.E234E	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	234	Coil 1B.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				GGGAGAGCTGCTCCTCCTTCA	0.692000													18	22					0	0	1	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6527981	6527981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6527981G>A	ENST00000377748.1	-	21	3643	c.3146C>T	c.(3145-3147)cCc>cTc	p.P1049L	PLEKHG5_ENST00000544978.1_Intron|PLEKHG5_ENST00000537245.1_Missense_Mutation_p.P1051L|PLEKHG5_ENST00000377737.2_Missense_Mutation_p.P972L|PLEKHG5_ENST00000400913.1_Missense_Mutation_p.P972L|PLEKHG5_ENST00000377725.1_Intron|PLEKHG5_ENST00000535355.1_Missense_Mutation_p.P1041L|PLEKHG5_ENST00000377728.3_Missense_Mutation_p.P972L|PLEKHG5_ENST00000377740.3_Intron|PLEKHG5_ENST00000377732.1_Missense_Mutation_p.P1009L|PLEKHG5_ENST00000340850.5_Missense_Mutation_p.P972L|PLEKHG5_ENST00000400915.3_Missense_Mutation_p.P1028L	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	1028					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CCCTGGTGGGGGCTCAGGCTG	0.672000													5	8					0	0	1	0	0
BIVM-ERCC5	100533467	broad.mit.edu	37	13	103510682	103510682	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:103510682C>T	ENST00000602836.1	+	14	1862	c.1862C>T	c.(1861-1863)cCt>cTt	p.P621L	ERCC5_ENST00000535557.1_Silent_p.L196L|ERCC5_ENST00000355739.4_Silent_p.L196L	NM_001204425.1	NP_001191354.1	Q59FZ7	Q59FZ7_HUMAN		0					nucleotide-excision repair	nucleus	endonuclease activity|single-stranded DNA binding										CTTCAGCAGCCTGCCCCCTGA	0.388000													41	87					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190068213	190068213	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190068213C>T	ENST00000367462.3	-	8	1467	c.1236G>A	c.(1234-1236)gaG>gaA	p.E412E	FAM5C_ENST00000534846.1_Silent_p.E310E|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		412						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGAGGCCGTTCTCATTGCAGT	0.488000													13	27					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96790332	96790332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96790332G>A	ENST00000359933.4	-	16	3334	c.2441C>T	c.(2440-2442)tCg>tTg	p.S814L		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	814										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TTCCTGGAACGATCCTAAAAA	0.398000													12	43					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169696913	169696913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169696913C>T	ENST00000333360.7	-	9	1574	c.1435G>A	c.(1435-1437)Gga>Aga	p.G479R	SELE_ENST00000367780.4_Missense_Mutation_p.G354R|SELE_ENST00000367781.4_Missense_Mutation_p.G416R|SELE_ENST00000367779.4_Intron|SELE_ENST00000367782.4_Intron|SELE_ENST00000367777.1_Intron|SELE_ENST00000367775.1_Missense_Mutation_p.G354R|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367776.1_Missense_Mutation_p.G416R|SELE_ENST00000367774.1_Intron	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	479	Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					GTCCATTGTCCCTGAGATGTG	0.428000													30	118					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	134041097	134041097	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134041097C>T	ENST00000398844.2	+	17	2809	c.2521C>T	c.(2521-2523)Caa>Taa	p.Q841*		NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	841					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGCTGATGTTCAAGCAATTTC	0.353000													17	134					0	0	1	0	0
SDC4	6385	broad.mit.edu	37	20	43959189	43959189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43959189G>A	ENST00000372733.3	-	4	301	c.262C>T	c.(262-264)Cat>Tat	p.H88Y	SDC4_ENST00000537976.1_Missense_Mutation_p.H16Y	NM_002999.3	NP_002990.2	P31431	SDC4_HUMAN	syndecan 4	88						extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity		SDC4/ROS1(7)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)	5		Myeloproliferative disorder(115;0.0122)				TCAGGGATATGGTTATCTAGA	0.542000			T	ROS1	NSCLC								15	30					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35624433	35624433	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:35624433C>A	ENST00000287272.2	+	14	2140	c.2120C>A	c.(2119-2121)tCc>tAc	p.S707Y	UNC5D_ENST00000416672.1_Missense_Mutation_p.S781Y|UNC5D_ENST00000420357.1_Missense_Mutation_p.S709Y|UNC5D_ENST00000404895.2_Missense_Mutation_p.S776Y|UNC5D_ENST00000453357.2_Missense_Mutation_p.S771Y|UNC5D_ENST00000449677.1_Missense_Mutation_p.S352Y			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	776	Interaction with DCC (By similarity).				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GTCCCGTTCTCCCGCGTGTGG	0.562000													9	44					0.00621372	0.00621734	1	1	0
CELSR3	1951	broad.mit.edu	37	3	48684207	48684207	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48684207G>A	ENST00000544264.1	-	22	7579	c.7299C>T	c.(7297-7299)cgC>cgT	p.R2433R	CELSR3_ENST00000164024.4_Silent_p.R2428R			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2428					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGGCACCTCGGCGTTCTGCCT	0.597000													8	30					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73072163	73072163	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73072163G>A	ENST00000429829.1	-	0	425					NR_001564.2																						AGGTATCCACGGCCCCGTTGG	0.438000													8	4					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247151348	247151348	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247151348G>A	ENST00000339986.7	-	4	616	c.469C>T	c.(469-471)Caa>Taa	p.Q157*	ZNF695_ENST00000498046.2_Intron|ZNF695_ENST00000487338.2_Intron	NM_020394.4	NP_065127.4	Q8IW36	ZN695_HUMAN	zinc finger protein 695	157					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTATTGCATTGAAAGTTTTTG	0.358000													52	226					0	0	1	0	0
TNFRSF10C	8794	broad.mit.edu	37	8	22972217	22972217	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22972217G>A	ENST00000540813.1	+	0	309				TNFRSF10C_ENST00000356864.3_Missense_Mutation_p.G72S|TNFRSF10C_ENST00000520607.1_3'UTR			O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain						apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(6)|lung(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		GTGCACAGAGGGTGTGGATTA	0.478000													44	89					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73474369	73474369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73474369G>A	ENST00000252034.7	+	23	1967	c.1568G>A	c.(1567-1569)gGa>gAa	p.G523E	ELN_ENST00000380576.5_Missense_Mutation_p.G504E|ELN_ENST00000458204.1_Missense_Mutation_p.G513E|ELN_ENST00000380575.4_Missense_Mutation_p.G494E|ELN_ENST00000320492.7_Missense_Mutation_p.G442E|ELN_ENST00000414324.1_Missense_Mutation_p.G499E|ELN_ENST00000380553.4_Missense_Mutation_p.G387E|ELN_ENST00000357036.5_Missense_Mutation_p.G528E|ELN_ENST00000429192.1_Missense_Mutation_p.G509E|ELN_ENST00000380584.4_Missense_Mutation_p.G490E|ELN_ENST00000358929.4_Missense_Mutation_p.G558E|ELN_ENST00000445912.1_Missense_Mutation_p.G523E|ELN_ENST00000380562.4_Missense_Mutation_p.G529E|CTB-51J22.1_ENST00000435932.1_RNA|ELN_ENST00000320399.6_Missense_Mutation_p.G523E	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	552	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	GGCCCTGGTGGAGTTGCAGGT	0.642000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						10	113					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34400213	34400213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:34400213G>A	ENST00000374789.3	-	25	4280	c.3955C>T	c.(3955-3957)Ccc>Tcc	p.P1319S	PARD3_ENST00000374790.3_Missense_Mutation_p.P1259S|PARD3_ENST00000374794.3_Missense_Mutation_p.P1207S|PARD3_ENST00000545260.1_Missense_Mutation_p.P1229S|PARD3_ENST00000545693.1_Missense_Mutation_p.P1303S|PARD3_ENST00000374788.3_Missense_Mutation_p.P1316S|PARD3_ENST00000346874.4_Missense_Mutation_p.P1282S|PARD3_ENST00000350537.4_Missense_Mutation_p.P1273S	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1319					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				GCGTAACTGGGGTCCTGGACT	0.597000													15	61					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701623	56701623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56701623G>A	ENST00000586855.2	-	5	1374	c.1061C>T	c.(1060-1062)cCc>cTc	p.P354L	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.P354L			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	354					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ACATGCAAAGGGCGGCAGGGC	0.527000													29	82					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640889	3640889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3640889G>A	ENST00000294008.3	-	12	3390	c.2750C>T	c.(2749-2751)gCc>gTc	p.A917V		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	917	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CCAGGTGGTGGCGGCCTCATC	0.652000								Direct reversal of damage					29	117					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90119263	90119263	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90119263C>T	ENST00000405460.2	+	76	16314	c.16218C>T	c.(16216-16218)gtC>gtT	p.V5406V	GPR98_ENST00000425867.2_Silent_p.V1067V	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5406					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGTCAAGGTCTTTTGGCGAG	0.463000													24	59					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72992967	72992967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72992967G>A	ENST00000268489.5	-	2	1750	c.1078C>T	c.(1078-1080)Ccc>Tcc	p.P360S	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	360					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CTGTGTCCGGGGCCTATGAGG	0.522000													50	78					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5153839	5153839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5153839C>T	ENST00000252321.3	+	1	755	c.526C>T	c.(526-528)Ctc>Ttc	p.L176F		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	176						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						CGACGGTATCCTCTACTACTA	0.652000													8	73					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525760	176525760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176525760G>A	ENST00000367662.3	+	2	1466	c.302G>A	c.(301-303)gGa>gAa	p.G101E	PAPPA2_ENST00000367661.3_Missense_Mutation_p.G101E	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	101					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.G101E(2)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GACACTGAAGGAAATGCTGTG	0.567000													70	159					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440515	124440515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124440515C>T	ENST00000284287.3	+	1	623	c.551C>T	c.(550-552)cCc>cTc	p.P184L		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		TTAAAACTGCCCTATTGTGAG	0.483000													30	77					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21641163	21641163	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21641163C>T	ENST00000328843.6	+	18	3606	c.3575C>T	c.(3574-3576)cCt>cTt	p.P1192L	DNAH11_ENST00000409508.3_Missense_Mutation_p.P1192L			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1192	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CTCTTTGAACCTCTAAAAGAA	0.418000									Kartagener syndrome				5	35					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56350260	56350260	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56350260G>A	ENST00000340482.3	-	9	1913	c.1737C>T	c.(1735-1737)ctC>ctT	p.L579L	MPO_ENST00000225275.3_Silent_p.L547L			P05164	PERM_HUMAN	myeloperoxidase	547					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	TGAGGCCCCGGAGGATGGGGT	0.572000													59	182					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102900631	102900631	+	Missense_Mutation	SNP	C	C	T	rs150165045		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102900631C>T	ENST00000359520.7	+	9	1703	c.1477C>T	c.(1477-1479)Cct>Tct	p.P493S	TECPR2_ENST00000558678.1_Missense_Mutation_p.P493S	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	493							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CTCCGAATTTCCTGGGGACAG	0.507000													26	68					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936761	4936761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4936761G>A	ENST00000322013.3	-	1	161	c.133C>T	c.(133-135)Ccg>Tcg	p.P45S	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGTTGCCCGGGATGGAAACC	0.502000													17	79					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102036332	102036332	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102036332G>A	ENST00000549145.1	+	10	865	c.765G>A	c.(763-765)aaG>aaA	p.K255K	MYBPC1_ENST00000360610.2_Silent_p.K242K|MYBPC1_ENST00000541119.1_Silent_p.K230K|MYBPC1_ENST00000536007.1_Silent_p.K223K|MYBPC1_ENST00000553190.1_Silent_p.K242K|MYBPC1_ENST00000547509.1_Silent_p.K228K|MYBPC1_ENST00000547405.1_Silent_p.K216K|MYBPC1_ENST00000545503.2_Silent_p.K242K|MYBPC1_ENST00000441232.1_Silent_p.K242K|MYBPC1_ENST00000392934.3_Silent_p.K229K|MYBPC1_ENST00000361685.2_Silent_p.K267K|MYBPC1_ENST00000361466.2_Silent_p.K267K|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000551300.1_Silent_p.K143K|MYBPC1_ENST00000550270.1_Silent_p.K242K|MYBPC1_ENST00000452455.2_Silent_p.K242K			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	242	Ig-like C2-type 2.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						AGCGACTCAAGCGCATGCGCA	0.617000													7	16					0	0	1	0	0
PDK4	5166	broad.mit.edu	37	7	95221348	95221348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:95221348C>T	ENST00000005178.5	-	6	843	c.646G>A	c.(646-648)Gat>Aat	p.D216N		NM_002612.3	NP_002603.1	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase, isozyme 4	216	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			TAATACTGATCACAGAGCATC	0.313000													59	134					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114154743	114154743	+	Silent	SNP	G	G	A	rs138653304	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:114154743G>A	ENST00000393081.1	+	2	346	c.39G>A	c.(37-39)ccG>ccA	p.P13P	ACSL5_ENST00000433418.1_Silent_p.P13P|ACSL5_ENST00000479936.1_3'UTR|ACSL5_ENST00000356116.1_Silent_p.P69P|ACSL5_ENST00000354273.4_Silent_p.P13P|ACSL5_ENST00000354655.4_Silent_p.P13P	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	13					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		CCCCACTTCCGACCCCGGCGT	0.428000													64	143					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34014926	34014926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34014926G>A	ENST00000389232.4	+	44	6700	c.6630G>A	c.(6628-6630)gtG>gtA	p.V2210V	RYR3_ENST00000415757.3_Silent_p.V2210V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2210	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTGAGAGTGTGGAAGAAAACG	0.542000													40	104					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43039885	43039885	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43039885C>T	ENST00000394056.2	+	13	1875	c.1379_splice	c.e13-1	p.S460_splice	KLC4_ENST00000479388.1_Splice_Site_p.S460_splice|KLC4_ENST00000259708.3_Splice_Site_p.S478_splice|KLC4_ENST00000394058.1_Splice_Site_p.S460_splice|KLC4_ENST00000453940.2_Splice_Site_p.S383_splice|KLC4_ENST00000347162.5_Splice_Site_p.S460_splice			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	460						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			CTCACCACAGCCCCACAGTGA	0.483000													9	124					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41798316	41798316	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41798316C>A	ENST00000392006.3	+	8	1339	c.1166C>A	c.(1165-1167)cCc>cAc	p.P389H	HNRNPUL1_ENST00000378215.4_Missense_Mutation_p.P275H|HNRNPUL1_ENST00000595018.1_Missense_Mutation_p.P289H|HNRNPUL1_ENST00000593587.1_Missense_Mutation_p.P289H|HNRNPUL1_ENST00000602130.1_Missense_Mutation_p.P389H|HNRNPUL1_ENST00000352456.3_Missense_Mutation_p.P289H|HNRNPUL1_ENST00000263367.3_Missense_Mutation_p.P300H	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	389	Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						AGAGCAGAGCCCTACTGTTCT	0.557000													34	84					6.50621e-10	6.5315e-10	1	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140773318	140773318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140773318C>T	ENST00000398604.2	+	1	938	c.938C>T	c.(937-939)tCa>tTa	p.S313L	PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGAATGTTCATTTTATGAA	0.358000													38	153					0	0	1	0	0
APBB1	322	broad.mit.edu	37	11	6432347	6432347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6432347G>A	ENST00000389906.2	-	2	330	c.231C>T	c.(229-231)ctC>ctT	p.L77L	APBB1_ENST00000533407.1_Intron|APBB1_ENST00000299402.6_Silent_p.L77L|APBB1_ENST00000311051.3_Silent_p.L77L	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	77					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CGGCCCGCCGGAGCTGGTTCT	0.677000													36	131					0	0	1	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32503507	32503507	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32503507G>T	ENST00000327300.7	+	6	1144	c.977G>T	c.(976-978)gGt>gTt	p.G326V	KHDRBS1_ENST00000307714.8_3'UTR|KHDRBS1_ENST00000492989.1_Missense_Mutation_p.G287V	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	326	Arg/Gly-rich.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ATCACCAGAGGTGCCACTGTG	0.577000													66	143					7.59065e-32	7.6425e-32	1	1	0
PCNXL4	64430	broad.mit.edu	37	14	60592362	60592362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:60592362C>T	ENST00000406854.1	+	10	3642	c.3088C>T	c.(3088-3090)Ctg>Ttg	p.L1030L	PCNXL4_ENST00000535349.1_Silent_p.L237L|PCNXL4_ENST00000404681.2_Silent_p.L1030L|PCNXL4_ENST00000317623.4_Silent_p.L796L|PCNXL4_ENST00000406949.1_Silent_p.L796L					pecanex-like 4 (Drosophila)																		TAGGTATACTCTGAAACTAAT	0.294000													5	4					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54573724	54573724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:54573724G>A	ENST00000064571.2	-	3	1795	c.495C>T	c.(493-495)gtC>gtT	p.V165V		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	165	C1q.					cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			GGTAGAGCAGGACACCATTCG	0.423000													44	78					0	0	1	0	0
OR2K2	26248	broad.mit.edu	37	9	114090533	114090533	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114090533A>G	ENST00000374428.1	-	1	267	c.268T>C	c.(268-270)Tta>Cta	p.L90L	OR2K2_ENST00000302681.1_Silent_p.L61L			Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K, member 2	90					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)	20						CCAAGGAATAAGTACATGGGG	0.413000													21	86					0	0	1	0	0
ZNF480	147657	broad.mit.edu	37	19	52825556	52825556	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52825556C>T	ENST00000595962.1	+	5	1119	c.1053C>T	c.(1051-1053)gcC>gcT	p.A351A	CTD-2525I3.6_ENST00000594379.1_RNA|ZNF480_ENST00000335090.6_Silent_p.A274A|ZNF480_ENST00000490272.1_3'UTR|ZNF480_ENST00000334564.7_Silent_p.A308A	NM_144684.2	NP_653285.2	Q8WV37	ZN480_HUMAN	zinc finger protein 480	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		GTGGCAAGGCCTTCTATAGGA	0.378000													29	68					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052332	44052332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:44052332C>T	ENST00000306006.6	-	2	1848	c.1196G>A	c.(1195-1197)gGa>gAa	p.G399E	ZNF239_ENST00000374446.2_Missense_Mutation_p.G399E|ZNF239_ENST00000535642.1_Missense_Mutation_p.G399E|ZNF239_ENST00000426961.1_Missense_Mutation_p.G399E	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GGGCTTCTCTCCAGTGTGGAC	0.522000													25	51					0	0	1	0	0
GATM	2628	broad.mit.edu	37	15	45656180	45656180	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45656180G>A	ENST00000396659.3	-	8	1416	c.1077C>T	c.(1075-1077)tcC>tcT	p.S359S	GATM_ENST00000558336.1_Silent_p.S359S	NM_001482.2	NP_001473.1	P50440	GATM_HUMAN	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	359					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	15		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	AGACATTCATGGAAAGCCATT	0.358000													33	68					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65145865	65145865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:65145865C>T	ENST00000381210.3	-	12	1127	c.1017G>A	c.(1015-1017)aaG>aaA	p.K339K	TECRL_ENST00000507440.1_Intron	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	339					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						TCTTATGTTTCTTTTGTGCCC	0.254000													13	37					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178942511	178942511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:178942511C>T	ENST00000263967.3	+	16	2475	c.2318C>T	c.(2317-2319)tCc>tTc	p.S773F		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	773					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CGAATTATGTCCTCTGCAAAA	0.328000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			31	95					0	0	1	0	0
SLA	6503	broad.mit.edu	37	8	134057256	134057256	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134057256G>A	ENST00000338087.5	-	7	1276	c.457C>T	c.(457-459)Ctg>Ttg	p.L153L	TG_ENST00000542445.1_Intron|SLA_ENST00000524345.1_Silent_p.L45L|TG_ENST00000220616.4_Intron|TG_ENST00000519543.1_Intron|TG_ENST00000377869.1_Intron|SLA_ENST00000427060.2_Silent_p.L193L|SLA_ENST00000517648.1_Intron|SLA_ENST00000395352.3_Silent_p.L170L	NM_001045556.2	NP_001039021.1	Q13239	SLAP1_HUMAN	Src-like-adaptor	153	SH2.					endosome	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(6)|prostate(1)|skin(1)	17	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			AGGTCCTCCAGGCACTGGAAG	0.512000													18	50					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72539488	72539488	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72539488C>T	ENST00000299290.1	-	5	677	c.288G>A	c.(286-288)ggG>ggA	p.G96G	TBATA_ENST00000456372.2_Silent_p.G96G|TBATA_ENST00000545575.1_Silent_p.G86G	NM_152710.2	NP_689923.2			thymus, brain and testes associated																		AGACAGGCTTCCCGGTGAGAT	0.562000													16	42					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134188628	134188628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:134188628C>T	ENST00000431683.2	+	19	1883	c.1883C>T	c.(1882-1884)cCa>cTa	p.P628L		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	628					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TGGCTTCATCCAGAAGACAAT	0.408000													4	16					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42853768	42853768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42853768C>T	ENST00000334370.4	+	13	2850	c.2215C>T	c.(2215-2217)Cag>Tag	p.Q739*	MEGF8_ENST00000251268.6_Nonsense_Mutation_p.Q806*	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	806						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				AGTAGAGATCCAGGGCCAGCT	0.652000													5	52					0	0	1	0	0
MIR492	574449	broad.mit.edu	37	12	95228202	95228202	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95228202G>A	ENST00000385303.1	+	0	29					NR_030171.1																						CAGGACCATCGAGGACCTGCG	0.552000													12	41					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2740325	2740325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2740325C>T	ENST00000312371.4	+	2	608	c.240C>T	c.(238-240)ttC>ttT	p.F80F	AMZ1_ENST00000407112.1_Silent_p.F80F	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	80							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		TCCAGACCTTCCACGCCTCCC	0.667000													35	90					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64630177	64630177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:64630177C>T	ENST00000357395.3	+	90	16656	c.5512C>T	c.(5512-5514)Ctg>Ttg	p.L1838L	ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000344113.4_Silent_p.L5453L|SYNE2_ENST00000554584.1_Silent_p.L5370L|SYNE2_ENST00000555002.1_Silent_p.L2087L|SYNE2_ENST00000358025.3_Silent_p.L5453L|SYNE2_ENST00000394768.2_Silent_p.L1838L			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5453					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTCCAGTGTCCTGGATCGACT	0.527000													19	80					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41900269	41900269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41900269G>A	ENST00000298919.7	+	4	463	c.75G>A	c.(73-75)aaG>aaA	p.K25K	PDZRN4_ENST00000539469.2_Silent_p.K27K|PDZRN4_ENST00000402685.2_Silent_p.K285K			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	285							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCAATGGGAAGGATCTTTCAA	0.438000													11	59					0	0	1	0	0
EID2B	126272	broad.mit.edu	37	19	40023290	40023290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40023290G>A	ENST00000326282.4	-	1	204	c.153C>T	c.(151-153)gcC>gcT	p.A51A	CTB-60E11.9_ENST00000594676.1_RNA|EID2B_ENST00000601837.1_Intron	NM_152361.1	NP_689574.1	Q96D98	EID2B_HUMAN	EP300 interacting inhibitor of differentiation 2B	51					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				endometrium(1)|lung(1)|urinary_tract(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCGCAGCTTCGGCCACTGGGC	0.756000													6	13					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57107002	57107002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:57107002G>A	ENST00000439986.4	-	8	859	c.822C>T	c.(820-822)ggC>ggT	p.G274G	CCBE1_ENST00000398179.2_Intron	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	274	Collagen-like 1.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				GCCCAGGAGGGCCTGGCATAC	0.602000													16	54					0	0	1	0	0
KRT85	3891	broad.mit.edu	37	12	52756698	52756698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52756698G>A	ENST00000257901.3	-	6	1092	c.1017C>T	c.(1015-1017)atC>atT	p.I339I	KRT85_ENST00000544265.1_Silent_p.I127I	NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	339	Coil 2.|Rod.				epidermis development	keratin filament	protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCAGCTCGTTGATCTCCTCCT	0.582000													27	61					0	0	1	0	0
LMO2	4005	broad.mit.edu	37	11	33880946	33880946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:33880946C>T	ENST00000257818.2	-	6	1469	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	LMO2_ENST00000395833.3_Missense_Mutation_p.E145K	NM_005574.3	NP_005565.2	P25791	RBTN2_HUMAN	LIM domain only 2 (rhombotin-like 1)	145					multicellular organismal development	nucleus	protein binding|zinc ion binding	p.E145K(1)		NS(1)|endometrium(2)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)|urinary_tract(1)	14						ATGTCCTGTTCGCACACTATG	0.502000			T	TRD@	T-ALL								12	37					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45555787	45555787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:45555787C>T	ENST00000588982.1	-	4	2205	c.1704G>A	c.(1702-1704)agG>agA	p.R568R	ZBTB7C_ENST00000586438.1_Silent_p.R568R|ZBTB7C_ENST00000535628.2_Silent_p.R568R|ZBTB7C_ENST00000590800.1_Silent_p.R568R|ZBTB7C_ENST00000332053.2_Silent_p.R568R			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	568						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CCCCCGCGTTCCTCTCAGCCT	0.736000													5	10					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71319397	71319397	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71319397G>T	ENST00000338099.5	-	3	763	c.427C>A	c.(427-429)Ctt>Att	p.L143I	FTSJD1_ENST00000434935.2_Missense_Mutation_p.L143I			Q8IYT2	FTSJ1_HUMAN		143						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCTTCACAAAGGTGTAGAGAA	0.413000													21	113					7.41877e-09	7.44479e-09	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79328522	79328522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79328522C>T	ENST00000376718.3	-	7	995	c.872G>A	c.(871-873)cGa>cAa	p.R291Q	PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	291					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AGCAATCTGTCGTCTCGGCTG	0.502000													3	9					0	0	1	0	0
HOXB2	3212	broad.mit.edu	37	17	46620486	46620486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46620486C>T	ENST00000330070.4	-	2	2182	c.1015G>A	c.(1015-1017)Gaa>Aaa	p.E339K	HOXB2_ENST00000504772.3_5'UTR	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	339					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						TCCAGCTCTTCCTCGGAAAAA	0.597000													39	76					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735154	55735154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55735154C>T	ENST00000312345.2	-	1	836	c.786G>A	c.(784-786)ggG>ggA	p.G262G		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AAATCAGTTTCCCCATCCTTT	0.373000													15	44					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28598107	28598107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28598107C>T	ENST00000434452.1	-	9	1347	c.1193G>A	c.(1192-1194)gGa>gAa	p.G398E	DSC3_ENST00000360428.4_Missense_Mutation_p.G398E	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	398	Cadherin 3.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ATTTTCATTTCCCTTTAAAAT	0.318000													29	96					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61570356	61570356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61570356C>T	ENST00000457692.1	+	9	1398	c.1065C>T	c.(1063-1065)ttC>ttT	p.F355F	SERPINB2_ENST00000299502.4_Silent_p.F355F	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	355					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CTGAAGTGTTCCACCAAGCCA	0.542000													27	83					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11630225	11630225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:11630225G>A	ENST00000423059.3	-	4	1566	c.1315C>T	c.(1315-1317)Cct>Tct	p.P439S		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	439	TSP type-1 4.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTGAGCAAAGGGTCCACACGG	0.537000										HNSCC(18;0.044)			5	26					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98916675	98916675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98916675G>A	ENST00000477737.1	+	25	3620	c.3416G>A	c.(3415-3417)cGg>cAg	p.R1139Q	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1139										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TGTAACAACCGGAGAGTAAGT	0.448000													44	105					0	0	1	0	0
PRB3	5544	broad.mit.edu	37	12	11420578	11420578	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11420578C>T	ENST00000381842.3	-	0	642				PRB3_ENST00000538488.1_RNA|PRB3_ENST00000440870.3_RNA|PRB3_ENST00000279573.6_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TTCTGGCTTTCCCGGACGAGG	0.627000													58	363					0	0	1	0	0
CDK8	1024	broad.mit.edu	37	13	26974631	26974631	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:26974631C>T	ENST00000381527.3	+	10	1478	c.975C>T	c.(973-975)acC>acT	p.T325T	CDK8_ENST00000480323.1_3'UTR|CDK8_ENST00000536792.1_3'UTR	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	325	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGCGAATTACCTCAGAACAGG	0.423000													17	204					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584536	7584536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7584536C>T	ENST00000379802.3	+	24	7382	c.7041C>T	c.(7039-7041)atC>atT	p.I2347I	DSP_ENST00000418664.2_Silent_p.I1748I	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2347	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CAGGAAACATCATCTCTTTGT	0.473000													15	68					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19337321	19337321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19337321G>A	ENST00000252575.5	+	7	1142	c.1099G>A	c.(1099-1101)Gac>Aac	p.D367N		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	367					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			ACAACATGGAGACCTAGAGAC	0.577000													13	91					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31645925	31645925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:31645925G>A	ENST00000357033.4	-	55	8288	c.8082C>T	c.(8080-8082)ttC>ttT	p.F2694F	DMD_ENST00000378707.3_Silent_p.F234F|DMD_ENST00000378677.2_Silent_p.F2690F|DMD_ENST00000359836.1_Silent_p.F234F|DMD_ENST00000541735.1_Silent_p.F234F|DMD_ENST00000474231.1_Silent_p.F234F|DMD_ENST00000343523.2_Silent_p.F234F	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2694					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGTCCAGGGGGAACTGTTGCA	0.453000													10	11					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169939973	169939973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169939973C>T	ENST00000327239.4	+	6	1952	c.448C>T	c.(448-450)Cct>Tct	p.P150S	DHRS9_ENST00000428522.1_Missense_Mutation_p.P150S|DHRS9_ENST00000421653.1_Missense_Mutation_p.P3S|DHRS9_ENST00000412271.1_Missense_Mutation_p.P150S|DHRS9_ENST00000602501.1_Missense_Mutation_p.P150S|DHRS9_ENST00000436483.2_Missense_Mutation_p.P150S|DHRS9_ENST00000357546.2_Missense_Mutation_p.P150S|DHRS9_ENST00000432060.2_Missense_Mutation_p.P210S	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	150					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						AAATATGCTTCCTTTGGTCAA	0.483000													39	115					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76757136	76757136	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76757136C>T	ENST00000536229.3	+	3	3811	c.3102C>T	c.(3100-3102)ccC>ccT	p.P1034P	SALL3_ENST00000575389.2_Silent_p.P1167P|SALL3_ENST00000537592.2_Silent_p.P1239P			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCGGCATCCCCCAGCTCCCCG	0.617000													35	161					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10934538	10934538	+	Missense_Mutation	SNP	C	C	T	rs121909095		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10934538C>T	ENST00000314646.5	+	17	2020	c.1856C>T	c.(1855-1857)tCg>tTg	p.S619L	DNM2_ENST00000359692.6_Missense_Mutation_p.S615L|DNM2_ENST00000389253.4_Missense_Mutation_p.S619L|DNM2_ENST00000355667.6_Missense_Mutation_p.S619L|DNM2_ENST00000408974.4_Missense_Mutation_p.S615L|DNM2_ENST00000585892.1_Missense_Mutation_p.S619L			P50570	DYN2_HUMAN	dynamin 2	619	PH.		S -> L (in ADCNM; severe).|S -> W (in ADCNM; severe).		G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TGGAAGGCCTCGTTCCTCCGA	0.677000			"""F, N, Splice, Mis, O"""		ETP ALL								23	60					0	0	1	0	0
LCE1E	353135	broad.mit.edu	37	1	152760099	152760099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152760099G>A	ENST00000368770.3	+	2	377	c.324G>A	c.(322-324)ggG>ggA	p.G108G	LCE1E_ENST00000368771.1_Silent_p.G108G	NM_178353.1	NP_848130.1	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	108	Cys-rich.				keratinization					lung(5)|stomach(1)	6	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGTGGAGGGGGCAGCGGCC	0.617000													43	130					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189868721	189868721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189868721C>T	ENST00000304636.3	+	39	2845	c.2675C>T	c.(2674-2676)cCc>cTc	p.P892L	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	892	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AACCCAGGACCCCCAGGTCCC	0.428000													4	25					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2800046	2800046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2800046G>A	ENST00000520002.1	-	70	11041	c.10486C>T	c.(10486-10488)Cct>Tct	p.P3496S	CSMD1_ENST00000542608.1_Missense_Mutation_p.P3318S|CSMD1_ENST00000400186.3_Missense_Mutation_p.P3319S|CSMD1_ENST00000602557.1_Missense_Mutation_p.P3496S|CSMD1_ENST00000537824.1_Missense_Mutation_p.P3495S|CSMD1_ENST00000602723.1_Missense_Mutation_p.P3319S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3496						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCAAAGAAAGGAACCAGAATG	0.418000													5	14					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502575	90502575	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90502575G>A	ENST00000325643.5	+	4	3239	c.3173G>A	c.(3172-3174)gGa>gAa	p.G1058E		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCAAGTTCGGGAAGTGTTCAG	0.597000													16	88					0	0	1	0	0
PRKCSH	5589	broad.mit.edu	37	19	11558330	11558330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11558330C>T	ENST00000252455.2	+	11	1262	c.926C>T	c.(925-927)tCg>tTg	p.S309L	PRKCSH_ENST00000412601.1_Missense_Mutation_p.S309L|PRKCSH_ENST00000587327.1_Missense_Mutation_p.S309L|PRKCSH_ENST00000589838.1_Missense_Mutation_p.S309L|PRKCSH_ENST00000591462.1_Missense_Mutation_p.S309L|PRKCSH_ENST00000592741.1_Missense_Mutation_p.S309L	NM_002743.2	NP_002734.2	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H	309					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(3)	19						CCAGTGCCCTCGTCGCCCACA	0.667000													12	28					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32813968	32813968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32813968C>T	ENST00000380250.3	+	46	7133	c.6637C>T	c.(6637-6639)Cat>Tat	p.H2213Y		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TCGATACCTTCATGAAGCATA	0.428000													15	68					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176915162	176915162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176915162C>T	ENST00000367654.2	-	13	2186	c.2173G>A	c.(2173-2175)Gag>Aag	p.E725K	ASTN1_ENST00000424564.2_Missense_Mutation_p.E717K|ASTN1_ENST00000367657.3_Missense_Mutation_p.E717K|ASTN1_ENST00000361833.2_Missense_Mutation_p.E717K|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	725					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						ATGGGAAGCTCCCTGCTTTCC	0.532000													31	90					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47767944	47767944	+	Missense_Mutation	SNP	G	G	A	rs147160336	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47767944G>A	ENST00000360380.3	-	5	590	c.227C>T	c.(226-228)tCg>tTg	p.S76L	STIL_ENST00000371877.3_Missense_Mutation_p.S76L|STIL_ENST00000396221.2_Missense_Mutation_p.S76L|STIL_ENST00000337817.5_Missense_Mutation_p.S76L|STIL_ENST00000243182.6_Missense_Mutation_p.S76L			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	76					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				AAAGCATGACGAATTTTTTTT	0.413000													21	66					0	0	1	0	0
FCER2	2208	broad.mit.edu	37	19	7754151	7754151	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7754151C>T	ENST00000346664.5	-	11	1106	c.894G>A	c.(892-894)gaG>gaA	p.E298E	FCER2_ENST00000360067.4_Silent_p.E297E|FCER2_ENST00000597921.1_Silent_p.E298E	NM_001220500.1|NM_002002.4	NP_001207429.1|NP_001993.2	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor for (CD23)	298					positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10						GTCCCATGGACTCCGCGGAAC	0.672000													8	20					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14107221	14107221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:14107221C>T	ENST00000235372.7	+	8	3787	c.2931C>T	c.(2929-2931)ccC>ccT	p.P977P	PRDM2_ENST00000343137.4_Silent_p.P776P|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000413440.1_Silent_p.P776P|PRDM2_ENST00000311066.5_Silent_p.P977P|PRDM2_ENST00000505823.1_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	977	Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CACCCTGTCCCCCGGTATTAA	0.607000													18	179					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33875446	33875446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33875446G>A	ENST00000374408.3	-	4	1232	c.1136C>T	c.(1135-1137)tCg>tTg	p.S379L		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	379										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			ACCCAGGGACGAGGACACCAC	0.632000													11	25					0	0	1	0	0
PUS7L	83448	broad.mit.edu	37	12	44148716	44148716	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:44148716G>A	ENST00000416848.2	-	2	821	c.333C>T	c.(331-333)atC>atT	p.I111I	PUS7L_ENST00000553166.1_Silent_p.I111I|PUS7L_ENST00000431332.3_Intron|PUS7L_ENST00000344862.5_Silent_p.I111I|PUS7L_ENST00000551923.1_Silent_p.I111I	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	111					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TTCCATCAACGATAGTATCTT	0.348000													26	63					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63883878	63883878	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63883878G>A	ENST00000246841.3	+	2	1182	c.139G>A	c.(139-141)Gag>Aag	p.E47K	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	19	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CTTCCTGACGGAGGTCATCGA	0.637000													13	35					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98351872	98351872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98351872G>A	ENST00000264972.5	+	10	1457	c.1242G>A	c.(1240-1242)atG>atA	p.M414I	ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000442208.1_Missense_Mutation_p.M288I|ZAP70_ENST00000451498.2_Missense_Mutation_p.M107I	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	414	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						TGCTGGTCATGGAGATGGCTG	0.677000													25	152					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116858451	116858451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116858451G>A	ENST00000374118.3	-	6	598	c.361C>T	c.(361-363)Cct>Tct	p.P121S	KIF12_ENST00000473174.1_Intron	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	254	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						CCACCAACAGGGGGCTCCCCA	0.597000													7	55					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42221651	42221651	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42221651C>T	ENST00000221992.6	+	5	1350	c.1237_splice	c.e5+1	p.L412_splice	CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000398599.4_Splice_Site_p.L411_splice|CEACAM5_ENST00000405816.1_Splice_Site_p.L412_splice	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	412	Ig-like 4.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TGAATGTCCTCTGTGAGTATC	0.512000													66	154					0	0	1	0	0
RPS5	6193	broad.mit.edu	37	19	58906062	58906062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58906062C>T	ENST00000596046.1	+	5	1409	c.560C>T	c.(559-561)tCc>tTc	p.S187F	RPS5_ENST00000598098.1_Missense_Mutation_p.S117F|RPS5_ENST00000601521.1_Missense_Mutation_p.S187F|RPS5_ENST00000598495.1_Missense_Mutation_p.S208F|RPS5_ENST00000196551.3_Missense_Mutation_p.S187F			P46782	RS5_HUMAN	ribosomal protein S5	187					endocrine pancreas development|regulation of translational fidelity|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|structural constituent of ribosome			cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4		all_cancers(17;1.71e-22)|all_epithelial(17;1.69e-16)|Lung NSC(17;2.25e-06)|all_lung(17;9.97e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Breast(46;0.0194)|Ovarian(87;0.0443)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.171)|GBM - Glioblastoma multiforme(193;0.0323)|Lung(386;0.0543)|LUSC - Lung squamous cell carcinoma(496;0.176)		TCCTCGAACTCCTATGCCATT	0.567000													46	124					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112998264	112998264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112998264C>T	ENST00000495514.1	+	12	2686	c.1982C>T	c.(1981-1983)cCa>cTa	p.P661L	BOC_ENST00000355385.3_Missense_Mutation_p.P661L|BOC_ENST00000273395.4_Missense_Mutation_p.P662L			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	661	Fibronectin type-III 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			GCCATCCCCCCATCGCGGCTG	0.627000													12	55					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118520021	118520021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:118520021G>A	ENST00000359236.5	-	3	851	c.575C>T	c.(574-576)tCg>tTg	p.S192L		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	192	Ig-like C2-type 2.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						GAGGTTTGGCGATATCAGTAA	0.517000													20	76					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111861848	111861848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111861848G>A	ENST00000369740.1	+	10	1125	c.1022G>A	c.(1021-1023)aGc>aAc	p.S341N	CHIA_ENST00000353665.6_Missense_Mutation_p.S180N|CHIA_ENST00000343320.6_Missense_Mutation_p.S341N|CHIA_ENST00000430615.1_Missense_Mutation_p.S233N|CHIA_ENST00000451398.2_Missense_Mutation_p.S180N|CHIA_ENST00000483391.1_Missense_Mutation_p.S180N|RP5-1125M8.2_ENST00000426321.1_RNA	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	341					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		AACATCAAGAGCTTCGATATT	0.478000													27	71					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45412651	45412651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45412651C>T	ENST00000331493.2	+	5	531	c.120C>T	c.(118-120)atC>atT	p.I40I	ITGB3_ENST00000560629.1_3'UTR|EFCAB13_ENST00000520802.1_Intron|EFCAB13_ENST00000517484.1_Silent_p.I40I|ITGB3_ENST00000435993.2_3'UTR	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		AGAAATACATCAAGTTTTCTA	0.318000													45	67					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39793585	39793585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39793585C>T	ENST00000373272.2	+	13	1635	c.1230C>T	c.(1228-1230)atC>atT	p.I410I	PLCG1_ENST00000373271.1_Silent_p.I410I|PLCG1_ENST00000244007.3_Silent_p.I410I	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	410	PI-PLC X-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				ACCCAGTCATCCTGTCCATTG	0.547000													27	48					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38858758	38858758	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38858758C>T	ENST00000409235.3	+	26	3116	c.3001C>T	c.(3001-3003)Cac>Tac	p.H1001Y	CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Missense_Mutation_p.H961Y	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	1001					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						CATCATGTCCCACGAGAGCCC	0.602000													40	85					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83456109	83456109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83456109C>T	ENST00000334574.8	-	2	215	c.34G>A	c.(34-36)Gac>Aac	p.D12N	FSD2_ENST00000541889.1_Missense_Mutation_p.D12N			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	12										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						GTAGACCTGTCCAGCCCCAGT	0.468000													64	63					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15113846	15113846	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15113846G>A	ENST00000378217.3	+	8	971	c.784G>A	c.(784-786)Gga>Aga	p.G262R	OLAH_ENST00000485251.1_Intron|OLAH_ENST00000378228.3_Missense_Mutation_p.G209R	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	209					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						ATGTTTTGTTGGATCTGAAGA	0.323000													42	98					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87678484	87678484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:87678484G>A	ENST00000284262.2	+	2	1245	c.1003G>A	c.(1003-1005)Gag>Aag	p.E335K		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	335					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CACCAAGGAGGAGGGCAAGTA	0.662000													15	52					0	0	1	0	0
LBP	3929	broad.mit.edu	37	20	36979297	36979297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36979297C>T	ENST00000217407.2	+	3	484	c.323C>T	c.(322-324)tCc>tTc	p.S108F		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	108					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				ATCTCCGACTCCTCCATCCGG	0.612000													29	69					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65124444	65124444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:65124444G>A	ENST00000371073.2	+	13	1839	c.1839G>A	c.(1837-1839)gtG>gtA	p.V613V	CACHD1_ENST00000290039.5_Silent_p.V562V|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	613					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						AAATACCTGTGAAACAACTGA	0.448000													8	11					0	0	1	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77515942	77515942	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:77515942G>A	ENST00000477717.1	+	4	906		c.e4-1			NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5						protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						GTTCCTTCCAGGAAGATATCC	0.423000													11	175					0	0	1	0	0
CNN3	1266	broad.mit.edu	37	1	95368697	95368697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:95368697G>A	ENST00000370206.4	-	3	610	c.227C>T	c.(226-228)tCc>tTc	p.S76F	CNN3_ENST00000487539.1_5'UTR|CNN3_ENST00000545882.1_Missense_Mutation_p.S35F|CNN3_ENST00000538964.1_Missense_Mutation_p.S76F|CNN3_ENST00000394202.4_Missense_Mutation_p.S76F	NM_001839.3	NP_001830.1	Q15417	CNN3_HUMAN	calponin 3, acidic	76	CH.				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|stomach(1)|urinary_tract(2)	18		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		GTTCAGTGAGGACTCGTTGAC	0.403000													25	47					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113418951	113418951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113418951G>A	ENST00000297405.5	-	35	5855	c.5611C>T	c.(5611-5613)Cct>Tct	p.P1871S	CSMD3_ENST00000455883.2_Missense_Mutation_p.P1767S|CSMD3_ENST00000343508.3_Missense_Mutation_p.P1831S|CSMD3_ENST00000352409.3_Missense_Mutation_p.P1801S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1871						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTTGTTCTAGGAACAGCTGTG	0.318000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			41	56					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25834646	25834646	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25834646G>A	ENST00000399878.3	-	5	1191	c.1069C>T	c.(1069-1071)Cga>Tga	p.R357*	SEL1L3_ENST00000502949.1_Nonsense_Mutation_p.R204*|SEL1L3_ENST00000264868.5_Nonsense_Mutation_p.R322*	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	357						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						ATATCCAGTCGAAACCACTCC	0.393000													29	71					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328875	88328875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:88328875C>T	ENST00000325089.6	+	2	1451	c.1232C>T	c.(1231-1233)cCc>cTc	p.P411L	SLITRK5_ENST00000400028.3_Missense_Mutation_p.P170L	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	411						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCCTACAATCCCAAGAAAATG	0.557000													10	25					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075173	9075173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9075173C>T	ENST00000397910.4	-	3	12476	c.12273G>A	c.(12271-12273)atG>atA	p.M4091I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4093	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.M4091I(4)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGCAAGGATCATTCCTCCAG	0.527000													27	61					0	0	1	0	0
GALNT5	11227	broad.mit.edu	37	2	158142628	158142628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158142628G>A	ENST00000259056.4	+	3	2208	c.1723G>A	c.(1723-1725)Gga>Aga	p.G575R		NM_014568.1	NP_055383.1	Q7Z7M9	GALT5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	575	Catalytic subdomain A.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(4)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	56						CAGGCTGGCAGGAGCACAGAA	0.343000													20	66					0	0	1	0	0
OPHN1	4983	broad.mit.edu	37	X	67293003	67293003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:67293003C>T	ENST00000355520.5	-	20	2466	c.1825G>A	c.(1825-1827)Gaa>Aaa	p.E609K	OPHN1_ENST00000540071.1_Missense_Mutation_p.E609K|OPHN1_ENST00000484842.1_5'UTR	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	609					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						CCTTCGCTTTCATCCAGGGAA	0.483000													9	2					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058091	79058091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79058091C>T	ENST00000388820.4	-	19	4372	c.4162G>A	c.(4162-4164)Gtc>Atc	p.V1388I		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1388					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GTCTCAGGGACTCTGTGGCTG	0.682000													7	75					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110468503	110468503	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110468503C>T	ENST00000378402.5	+	46	6991	c.6887C>T	c.(6886-6888)cCt>cTt	p.P2296L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2296	G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGCCTGTTCCTGTGACCTGG	0.363000										HNSCC(38;0.096)			3	28					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84592779	84592779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84592779C>T	ENST00000286744.5	+	17	2335	c.2111C>T	c.(2110-2112)cCc>cTc	p.P704L	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.P704L	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	704	TSP type-1 5.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GAGCCCTGTCCCCCCAGGTAT	0.542000													9	43					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16877459	16877459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:16877459G>A	ENST00000355661.3	-	5	318	c.308C>T	c.(307-309)cCg>cTg	p.P103L	PLEKHA7_ENST00000448080.2_Missense_Mutation_p.P103L|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.P103L|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	103					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						ATGTGGATTCGGCCTGTGAGG	0.532000													55	160					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30732918	30732918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30732918C>T	ENST00000217315.5	+	7	966	c.626C>T	c.(625-627)tCg>tTg	p.S209L	TM9SF4_ENST00000398022.2_Missense_Mutation_p.S226L			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	226						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GAGAAGAGTTCGTGCACTCTG	0.562000													23	52					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48428946	48428946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48428946G>A	ENST00000224605.2	-	2	1205	c.940C>T	c.(940-942)Cac>Tac	p.H314Y		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	314					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						TGCTGTGCGTGGGCGCGCGGC	0.716000													9	14					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23826227	23826227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23826227C>T	ENST00000354639.3	+	19	2770	c.2306C>T	c.(2305-2307)cCa>cTa	p.P769L	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Missense_Mutation_p.P792L|STK31_ENST00000355870.3_Missense_Mutation_p.P792L|STK31_ENST00000428484.1_Missense_Mutation_p.P769L	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	792	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GGGTTACTGCCATTGATATTC	0.378000													25	81					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87966146	87966146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87966146G>A	ENST00000327946.7	-	3	580	c.495C>T	c.(493-495)ttC>ttT	p.F165F		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	165						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AGAACATGACGAACTTCTGCC	0.617000										Multiple Myeloma(13;0.14)			6	58					0	0	1	0	0
CD38	952	broad.mit.edu	37	4	15826515	15826515	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:15826515G>A	ENST00000226279.2	+	3	512	c.375G>A	c.(373-375)tgG>tgA	p.W125*		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	125					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						TTCTTCTTTGGAGCAGAATAA	0.388000													19	86					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54798336	54798336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54798336G>A	ENST00000474759.1	+	13	1386	c.1338G>A	c.(1336-1338)caG>caA	p.Q446Q	CACNA2D3_ENST00000490478.1_Silent_p.Q352Q|CACNA2D3_ENST00000288197.5_Silent_p.Q446Q|CACNA2D3_ENST00000415676.2_Silent_p.Q446Q	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	446						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TCATCGACCAGGAGCATGATG	0.512000													39	74					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152521994	152521994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152521994C>T	ENST00000427231.2	-	42	5293	c.5091G>A	c.(5089-5091)gaG>gaA	p.E1697E	NEB_ENST00000604864.1_Silent_p.E1697E|NEB_ENST00000603639.1_Silent_p.E1697E|NEB_ENST00000172853.10_Silent_p.E1697E|NEB_ENST00000397345.3_Silent_p.E1697E|NEB_ENST00000409198.1_Silent_p.E1697E	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1697					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTCCAGGGACTCTATGGGCA	0.448000													7	14					0	0	1	0	0
OR8D4	338662	broad.mit.edu	37	11	123777308	123777308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123777308C>T	ENST00000321355.2	+	1	200	c.170C>T	c.(169-171)aCc>aTc	p.T57I		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		CAACTTCATACCCCCATGTAC	0.403000													42	147					0	0	1	0	0
GRAP2	9402	broad.mit.edu	37	22	40351840	40351840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40351840G>A	ENST00000344138.4	+	3	359	c.96G>A	c.(94-96)gaG>gaA	p.E32E	GRAP2_ENST00000407075.3_Silent_p.E32E|GRAP2_ENST00000543252.1_Silent_p.E32E|GRAP2_ENST00000540310.1_Intron|GRAP2_ENST00000478445.1_3'UTR|GRAP2_ENST00000399090.2_Intron|GRAP2_ENST00000544756.1_Intron	NM_004810.2	NP_004801.1	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	32	SH3 1.				cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						GTAACCAAGAGGAGTGGTTTA	0.458000													6	60					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48736830	48736830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48736830C>T	ENST00000316623.5	-	49	6400	c.5945G>A	c.(5944-5946)aGa>aAa	p.R1982K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1982	EGF-like 34; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGCACATTTTCTGGGTTCTAG	0.398000													49	106					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52250020	52250020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52250020G>A	ENST00000595042.1	-	3	369	c.228C>T	c.(226-228)tcC>tcT	p.S76S	FPR1_ENST00000304748.4_Silent_p.S76S	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	76					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	ATGGCAAAGTGGAGGTGAAAC	0.522000													34	60					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027077	37027077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37027077C>T	ENST00000358047.3	+	1	646	c.594C>T	c.(592-594)ctC>ctT	p.L198L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	198										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TGTCCTGTCTCCCCCCGGAGC	0.642000													21	15					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47650329	47650329	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47650329C>T	ENST00000398742.2	+	5	1879	c.1830C>T	c.(1828-1830)ttC>ttT	p.F610F	GPR111_ENST00000507065.1_Silent_p.F610F|GPR111_ENST00000296862.1_Silent_p.F678F			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	678					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						CCCTGGCCTTCCACATTATCT	0.478000													20	49					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55912872	55912872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55912872G>A	ENST00000373965.2	-	15	2187	c.1793C>T	c.(1792-1794)cCt>cTt	p.P598L	PCDH15_ENST00000395445.1_Missense_Mutation_p.P598L|PCDH15_ENST00000409834.1_Missense_Mutation_p.P202L|PCDH15_ENST00000437009.1_Missense_Mutation_p.P591L|PCDH15_ENST00000361849.3_Missense_Mutation_p.P591L|PCDH15_ENST00000373957.3_Missense_Mutation_p.P569L|PCDH15_ENST00000395433.1_Missense_Mutation_p.P569L|PCDH15_ENST00000395432.2_Missense_Mutation_p.P554L|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395446.1_Missense_Mutation_p.P591L|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373955.1_Missense_Mutation_p.P591L|PCDH15_ENST00000414778.1_Missense_Mutation_p.P596L|PCDH15_ENST00000395430.1_Missense_Mutation_p.P591L|PCDH15_ENST00000320301.6_Missense_Mutation_p.P591L|PCDH15_ENST00000395438.1_Missense_Mutation_p.P591L	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	591	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCGCTCTGCAGGAGGAGCATT	0.453000										HNSCC(58;0.16)			14	54					0	0	1	0	0
DIO3	1735	broad.mit.edu	37	14	102027848	102027848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102027848C>T	ENST00000510508.4	+	1	161	c.15C>T	c.(13-15)gcC>gcT	p.A5A	DIO3_ENST00000359323.3_5'UTR			P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	0					cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(3)|skin(1)	22		all_neural(303;0.185)				CTCGCCAGGCCACGTCGCGGT	0.667000													9	11					0	0	1	0	0
PGA5	5222	broad.mit.edu	37	11	61015963	61015963	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61015963G>A	ENST00000312403.5	+	6	914	c.729G>A	c.(727-729)tgG>tgA	p.W243*	PGA5_ENST00000451616.2_Nonsense_Mutation_p.W89*|PGA4_ENST00000422676.2_Nonsense_Mutation_p.W243*|CTD-2331C18.5_ENST00000537594.1_RNA	NM_014224.2	NP_055039.1	P00790	PEPA_HUMAN	pepsinogen 5, group I (pepsinogen A)	243					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			large_intestine(1)|skin(1)	2						GTCTGAACTGGGTGCCTGTTA	0.547000													81	206					0	0	1	0	0
MKNK1	8569	broad.mit.edu	37	1	47042299	47042299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47042299G>A	ENST00000371946.4	-	5	425	c.262C>T	c.(262-264)Cgg>Tgg	p.R88W	MKNK1_ENST00000371944.4_Silent_p.V17V|MKNK1_ENST00000371945.4_Missense_Mutation_p.R88W|MKNK1_ENST00000545730.1_Missense_Mutation_p.R88W|MKNK1_ENST00000428112.2_Missense_Mutation_p.R88W|MKNK1_ENST00000341183.5_Missense_Mutation_p.R88W	NM_003684.5	NP_003675.2	Q9BUB5	MKNK1_HUMAN	MAP kinase interacting serine/threonine kinase 1	88	Protein kinase.				intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	13	Acute lymphoblastic leukemia(166;0.155)					ACCCTACTCCGACTGTGCCCT	0.522000													36	103					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10428434	10428434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10428434G>A	ENST00000293677.6	-	12	2137	c.2056C>T	c.(2056-2058)Ccg>Tcg	p.P686S	CTD-2369P2.12_ENST00000586529.1_Missense_Mutation_p.P87S	NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	513						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GACCCCAGCGGGGAAGAGCCG	0.692000													4	14					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848668	73848668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73848668G>A	ENST00000523207.1	+	3	1666	c.1078G>A	c.(1078-1080)Gaa>Aaa	p.E360K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	360					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TGAGAAGGATGAAGATGCTAC	0.438000													40	182					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153431438	153431438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153431438G>A	ENST00000368723.3	-	2	162	c.52C>T	c.(52-54)Cac>Tac	p.H18Y	S100A7_ENST00000368722.1_Missense_Mutation_p.H18Y	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	18	EF-hand 1.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTGTATTTGTGAAACATGTCG	0.438000													54	144					0	0	1	0	0
USP44	84101	broad.mit.edu	37	12	95927254	95927254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95927254G>A	ENST00000258499.3	-	2	1067	c.779C>T	c.(778-780)tCc>tTc	p.S260F	USP44_ENST00000552440.1_Missense_Mutation_p.S260F|USP44_ENST00000393091.2_Missense_Mutation_p.S260F|USP44_ENST00000537435.2_Missense_Mutation_p.S260F	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	260					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						TTTAACTGAGGAGTCACTGAC	0.393000													23	98					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157737078	157737078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157737078C>T	ENST00000361516.3	-	6	1153	c.1105G>A	c.(1105-1107)Gag>Aag	p.E369K	FCRL2_ENST00000368181.4_Intron|FCRL2_ENST00000469986.1_Missense_Mutation_p.E116K|FCRL2_ENST00000392274.3_Missense_Mutation_p.E369K	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	369	Ig-like C2-type 4.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTGTTGGCCTCACAGGAGTAG	0.567000													30	129					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79364219	79364219	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79364219G>A	ENST00000444841.1	-	0	285																											AAGTAGATTGGAAAGTTTTGG	0.483000													3	10					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742556	23742556	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23742556G>A	ENST00000255890.4	-	0	653																											AGGGGCTGCAGGGCCACGTAG	0.642000													7	15					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70375179	70375179	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70375179C>T	ENST00000374051.3	+	4	955	c.633C>T	c.(631-633)atC>atT	p.I211I	NLGN3_ENST00000536169.1_Silent_p.I191I|NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000358741.3_Silent_p.I231I	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	231					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					GCAATGTCATCGTCATCACCC	0.542000													36	30					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76891507	76891507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76891507G>A	ENST00000409709.3	+	22	2946	c.2674G>A	c.(2674-2676)Gag>Aag	p.E892K	MYO7A_ENST00000409619.2_Missense_Mutation_p.E881K|MYO7A_ENST00000409893.1_Missense_Mutation_p.E892K|MYO7A_ENST00000458637.2_Missense_Mutation_p.E892K	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	892					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GGCCAAGGAGGAGGCCGAGCG	0.612000													6	22					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134886335	134886335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134886335C>T	ENST00000607359.1	+	3	369	c.369C>T	c.(367-369)ttC>ttT	p.F123F				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	505						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CCTCAGGGTTCTTGGGACCTG	0.582000													8	18					0	0	1	0	0
RAB37	326624	broad.mit.edu	37	17	72740483	72740483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72740483G>A	ENST00000340415.3	+	6	1391	c.382G>A	c.(382-384)Gac>Aac	p.D128N	RAB37_ENST00000392615.5_Missense_Mutation_p.D103N|RAB37_ENST00000392614.4_Missense_Mutation_p.D140N|RAB37_ENST00000392613.5_Missense_Mutation_p.D135N|RAB37_ENST00000392612.3_Missense_Mutation_p.D98N|RAB37_ENST00000392610.1_Missense_Mutation_p.D135N|RAB37_ENST00000528438.1_Missense_Mutation_p.D108N|RAB37_ENST00000402449.4_Missense_Mutation_p.D128N	NM_175738.4	NP_783865.1	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family	135					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	12						TGCCCAGAGGGACGTGGTGAT	0.612000											OREG0024716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	85					0	0	1	0	0
ABCF2	10061	broad.mit.edu	37	7	150915701	150915701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150915701G>A	ENST00000287844.2	-	10	1282	c.1173C>T	c.(1171-1173)atC>atT	p.I391I	ABCF2_ENST00000222388.2_Silent_p.I391I|ABCF2_ENST00000473874.1_5'UTR	NM_007189.1	NP_009120.1	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 2	391						ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(15)|ovary(1)|skin(2)	24			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGGTGGAGGGATCTTGCCAC	0.478000													10	67					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370509	38370509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38370509G>A	ENST00000322350.5	+	6	1003	c.657G>A	c.(655-657)atG>atA	p.M219I	EGFLAM_ENST00000354891.3_Missense_Mutation_p.M219I	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	219	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TGAGGGCAATGAATTCCCATG	0.562000													8	43					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7675417	7675417	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7675417C>T	ENST00000446248.2	+	8	998	c.897C>T	c.(895-897)ctC>ctT	p.L299L	CAMSAP3_ENST00000160298.4_Silent_p.L272L	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	272	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						ACCTCCAGCTCGTGCAGGATT	0.612000													53	158					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15582830	15582830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15582830C>T	ENST00000292609.4	-	3	1343	c.1214G>A	c.(1213-1215)gGa>gAa	p.G405E	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.G405E			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	405					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GTACAAGAATCCCAGCGGCAG	0.672000													13	38					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15843464	15843464	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:15843464C>T	ENST00000217246.4	+	9	1115	c.720C>T	c.(718-720)ttC>ttT	p.F240F	MACROD2_ENST00000310348.4_Silent_p.F240F|MACROD2_ENST00000378058.3_Silent_p.F5F|MACROD2_ENST00000402914.1_Silent_p.F5F	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	240	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				ATGAGTTTTTCTCCGTAGGTG	0.363000													9	33					0	0	1	0	0
KIF4A	24137	broad.mit.edu	37	X	69622482	69622482	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69622482A>T	ENST00000374403.3	+	23	2638	c.2556A>T	c.(2554-2556)caA>caT	p.Q852H	KIF4A_ENST00000374388.3_Missense_Mutation_p.Q852H	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	852	Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						GACCAAAACAACGCTGGGAGA	0.468000													14	17					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114380964	114380964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114380964G>A	ENST00000359785.5	-	13	1193	c.1058C>T	c.(1057-1059)tCc>tTc	p.S353F	PTPN22_ENST00000528414.1_Missense_Mutation_p.S298F|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000420377.2_Missense_Mutation_p.S353F|PTPN22_ENST00000525799.1_Missense_Mutation_p.S226F|PTPN22_ENST00000538253.1_Missense_Mutation_p.S109F	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	353					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGTCAAAGGAAGAAGATTC	0.348000													12	28					0	0	1	0	0
C7orf62	219557	broad.mit.edu	37	7	88423588	88423588	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:88423588G>A	ENST00000297203.2	-	2	854	c.669C>T	c.(667-669)ttC>ttT	p.F223F	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	223										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						CCGGGTCCATGAATTCTTCGG	0.438000													33	69					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230669	36230669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36230669G>A	ENST00000303965.4	-	2	929	c.440C>T	c.(439-441)tCt>tTt	p.S147F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	147					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTTAGGAGGAGACAGCTTATC	0.413000													26	62					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94052354	94052354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94052354G>A	ENST00000297268.6	+	40	2960	c.2489G>A	c.(2488-2490)cGa>cAa	p.R830Q		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	830			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCAGTTGGCCGAACTGGAGAA	0.562000										HNSCC(75;0.22)			40	92					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81181901	81181901	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81181901G>A	ENST00000525539.1	-	0	4814				PKD1L2_ENST00000533478.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GGTTGATGGGGAACATGAGGA	0.552000													15	39					0	0	1	0	0
WBP1	23559	broad.mit.edu	37	2	74687629	74687629	+	Missense_Mutation	SNP	G	G	A	rs143637433	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74687629G>A	ENST00000393972.3	+	5	936	c.733G>A	c.(733-735)Gac>Aac	p.D245N	WBP1_ENST00000494741.1_3'UTR|WBP1_ENST00000409737.1_Missense_Mutation_p.D208N|WBP1_ENST00000233615.2_Missense_Mutation_p.D211N			Q96G27	WBP1_HUMAN	WW domain binding protein 1	211							WW domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	8						TTTAACTGGCGACTCCGGTAT	0.652000													76	150					0	0	1	0	0
NR5A1	2516	broad.mit.edu	37	9	127262788	127262788	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127262788C>A	ENST00000373588.4	-	4	647	c.451G>T	c.(451-453)Ggc>Tgc	p.G151C		NM_004959.4	NP_004950.2	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	151					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			lung(1)|upper_aerodigestive_tract(1)	2						GCGGCCAGGCCCTTGGGCTCA	0.741000													15	17					1.99824e-07	2.0038e-07	1	1	0
SEPT5	5413	broad.mit.edu	37	22	19709226	19709226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19709226C>T	ENST00000438754.2	+	8	1088	c.808C>T	c.(808-810)Cgg>Tgg	p.R270W	SEPT5_ENST00000455784.2_Missense_Mutation_p.R261W|SEPT5_ENST00000383045.3_Missense_Mutation_p.R270W|SEPT5_ENST00000406395.1_Missense_Mutation_p.R261W	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	261					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					GCAGCGGGTCCGGGGCCGACT	0.677000													42	65					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176520147	176520147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176520147C>T	ENST00000292408.4	+	9	1311	c.1066C>T	c.(1066-1068)Ccc>Tcc	p.P356S	FGFR4_ENST00000502906.1_Missense_Mutation_p.P356S|FGFR4_ENST00000393648.2_Missense_Mutation_p.P356S|FGFR4_ENST00000393637.1_Intron|FGFR4_ENST00000292410.3_Intron	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	356					insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	AGAGGAGGACCCCACATGGAC	0.652000										TSP Lung(9;0.080)			18	43					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10221747	10221747	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10221747C>T	ENST00000428358.1	+	12	1500	c.1328C>T	c.(1327-1329)tCc>tTc	p.S443F	PPAN-P2RY11_ENST00000393796.4_Intron|PPAN_ENST00000253107.7_Missense_Mutation_p.S443F|PPAN_ENST00000556468.1_Intron|PPAN_ENST00000393793.1_Missense_Mutation_p.S390F	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		443					RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			AAGGACAAGTCCCAGGGAGCC	0.687000													20	36					0	0	1	0	0
ENDOV	284131	broad.mit.edu	37	17	78399335	78399335	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78399335C>T	ENST00000518137.1	+	7	657	c.629C>T	c.(628-630)tCc>tTc	p.S210F	ENDOV_ENST00000518901.1_Missense_Mutation_p.S16F|ENDOV_ENST00000517295.2_Missense_Mutation_p.S138F|ENDOV_ENST00000323854.5_Missense_Mutation_p.S165F|ENDOV_ENST00000517795.1_Missense_Mutation_p.S16F|ENDOV_ENST00000518907.1_Missense_Mutation_p.S16F|ENDOV_ENST00000520367.1_Missense_Mutation_p.S165F|ENDOV_ENST00000520284.1_Missense_Mutation_p.S16F|ENDOV_ENST00000522751.1_Missense_Mutation_p.S16F	NM_173627.3	NP_775898.2	Q8N8Q3	ENDOV_HUMAN	endonuclease V	210					DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding			endometrium(1)|lung(1)|pancreas(1)|prostate(1)	4						CTCTACATCTCCGTGGGCCAC	0.692000								Direct reversal of damage					5	6					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153696708	153696708	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153696708C>T	ENST00000369682.3	+	23	4201	c.4026C>T	c.(4024-4026)ttC>ttT	p.F1342F		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1342					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCGCGCGTTCGTGCTTACCT	0.697000													14	10					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28193390	28193390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:28193390C>T	ENST00000302326.4	-	1	4096	c.3142G>A	c.(3142-3144)Gag>Aag	p.E1048K		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	1048							binding	p.E1048K(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						GTGCTCACCTCGTCCGAGGCG	0.627000			T	ETV6	"""AML, meningioma"""								7	98					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129704356	129704356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:129704356G>A	ENST00000421865.2	+	35	5098	c.5049G>A	c.(5047-5049)aaG>aaA	p.K1683K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1683	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AATTCATTAAGGAGCTTGCCC	0.458000													10	16					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16217068	16217068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:16217068C>T	ENST00000339732.5	+	1	913	c.410C>T	c.(409-411)gCt>gTt	p.A137V	GALNT15_ENST00000470031.1_3'UTR|GALNT15_ENST00000437509.1_Missense_Mutation_p.A137V	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		GACTGGGGGGCTGATGAGGAC	0.637000													16	22					0	0	1	0	0
OR51V1	283111	broad.mit.edu	37	11	5221755	5221755	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5221755C>T	ENST00000321255.1	-	1	175	c.176G>A	c.(175-177)tGg>tAg	p.W59*		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCTCAGTCCATATCACATG	0.532000													27	77					0	0	1	0	0
IER5L	389792	broad.mit.edu	37	9	131939645	131939645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131939645G>A	ENST00000372491.2	-	1	895	c.687C>T	c.(685-687)ccC>ccT	p.P229P	RP11-247A12.8_ENST00000599172.2_RNA|RP11-247A12.2_ENST00000372490.3_RNA	NM_203434.2	NP_982258.2	Q5T953	IER5L_HUMAN	immediate early response 5-like	229	Ala-rich.												Ovarian(14;0.0448)|Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		gggaggaggcgggggccgggg	0.771000													8	14					0	0	1	0	0
LHX3	8022	broad.mit.edu	37	9	139089520	139089520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139089520G>A	ENST00000371746.3	-	6	978	c.860C>T	c.(859-861)gCc>gTc	p.A287V	LHX3_ENST00000371748.5_Missense_Mutation_p.A282V	NM_014564.3	NP_055379.1	Q9UBR4	LHX3_HUMAN	LIM homeobox 3	282					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	8		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		CCGGCCCAAGGCCTGGGTGGG	0.677000													4	15					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580724	140580724	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580724C>T	ENST00000354757.3	+	1	1377	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	PCDHB11_ENST00000536699.1_Silent_p.F94F	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		459	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.587000													62	223					0	0	1	0	0
SLC22A3	6581	broad.mit.edu	37	6	160857870	160857870	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160857870C>T	ENST00000392145.1	+	6	1061	c.1034C>T	c.(1033-1035)cCc>cTc	p.P345L	SLC22A3_ENST00000275300.2_Missense_Mutation_p.P345L			O75751	S22A3_HUMAN	solute carrier family 22 (organic cation transporter), member 3	345						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		GTGAGAACTCCCCAAATGAGG	0.343000													26	25					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10083645	10083645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10083645G>A	ENST00000264828.3	-	51	3809	c.3724C>T	c.(3724-3726)Ccc>Tcc	p.P1242S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1242	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TTGCCTGGGGGTCCAGCAGCT	0.612000													5	25					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33579405	33579405	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:33579405G>A	ENST00000228567.3	-	2	473	c.177C>T	c.(175-177)gtC>gtT	p.V59V	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	59						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					AGCTGACAACGACAGCTAACA	0.363000													16	17					0	0	1	0	0
CPB1	1360	broad.mit.edu	37	3	148577674	148577674	+	Missense_Mutation	SNP	G	G	A	rs144356818		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:148577674G>A	ENST00000491148.1	+	12	1473	c.1139G>A	c.(1138-1140)cGa>cAa	p.R380Q	CPB1_ENST00000498639.1_3'UTR|CPB1_ENST00000282957.4_Missense_Mutation_p.R380Q|RP11-680B3.2_ENST00000488190.1_RNA			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	380					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TTTGAACTTCGAGATACAGGC	0.498000													28	88					0	0	1	0	0
TRIM6	117854	broad.mit.edu	37	11	5626711	5626711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5626711G>A	ENST00000380097.3	+	4	990	c.748G>A	c.(748-750)Gat>Aat	p.D250N	TRIM6_ENST00000445329.1_Missense_Mutation_p.D47N|AC015691.13_ENST00000394793.2_RNA|TRIM6_ENST00000507320.1_Missense_Mutation_p.D47N|TRIM6_ENST00000506134.1_Missense_Mutation_p.D47N|TRIM6-TRIM34_ENST00000354852.5_Missense_Mutation_p.D250N|TRIM6_ENST00000515022.1_Missense_Mutation_p.D47N|TRIM6_ENST00000380107.1_Missense_Mutation_p.D196N|TRIM6_ENST00000278302.5_Missense_Mutation_p.D222N|HBG2_ENST00000380259.2_Intron	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		GGCTGAGAATGATCTGGTCCA	0.522000											OREG0003723	type=REGULATORY REGION|Gene=TRIM6|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	20	56					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532323	40532323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:40532323C>T	ENST00000297737.6	-	5	623	c.477G>A	c.(475-477)atG>atA	p.M159I	ZMAT4_ENST00000315769.7_Intron	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	159						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			GTTGCTGGGCCATCAGAGGGT	0.493000													46	204					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540842	55540842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55540842C>T	ENST00000220676.1	+	4	4548	c.4400C>T	c.(4399-4401)tCt>tTt	p.S1467F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1467					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GAATTGGAATCTTTTGAAGAA	0.378000													14	70					0	0	1	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967526	142967526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142967526G>A	ENST00000370494.1	+	1	354	c.324G>A	c.(322-324)tcG>tcA	p.S108S		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	108							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					TTCTGCTATCGATCCAGGCCT	0.423000													70	47					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128797335	128797335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128797335G>A	ENST00000274487.4	+	2	759	c.614G>A	c.(613-615)gGg>gAg	p.G205E		NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	205	Pro-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GGCCCCACGGGGGCAGCATCC	0.701000													12	29					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71747977	71747977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71747977G>A	ENST00000258104.3	+	11	1273	c.996G>A	c.(994-996)ggG>ggA	p.G332G	DYSF_ENST00000410041.1_Silent_p.G364G|DYSF_ENST00000429174.2_Silent_p.G332G|DYSF_ENST00000409744.1_Silent_p.G333G|DYSF_ENST00000410020.3_Silent_p.G364G|DYSF_ENST00000394120.2_Silent_p.G333G|DYSF_ENST00000409366.1_Silent_p.G333G|DYSF_ENST00000409582.3_Silent_p.G363G|DYSF_ENST00000413539.2_Silent_p.G363G|DYSF_ENST00000409651.1_Silent_p.G364G|DYSF_ENST00000409762.1_Silent_p.G363G	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	332						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TCTCTGCTGGGGCCAGAGGCT	0.572000													27	92					0	0	1	0	0
GCM2	9247	broad.mit.edu	37	6	10876198	10876198	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:10876198C>T	ENST00000379491.4	-	4	655	c.508G>A	c.(508-510)Gct>Act	p.A170T	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	170					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				CTTCTTCTAGCTTCTGTCTCT	0.453000													32	83					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803443	23803443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:23803443C>T	ENST00000264867.2	-	12	2322	c.2203G>A	c.(2203-2205)Gga>Aga	p.G735R	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	735	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				AAAGTGTATCCATTTTCAAGA	0.408000													4	49					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118969759	118969759	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:118969759G>A	ENST00000328252.3	+	3	1872	c.1503G>A	c.(1501-1503)ctG>ctA	p.L501L	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	501	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TTAATGAGCTGAAGAACATTC	0.413000													22	72					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059419	248059419	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248059419C>T	ENST00000537741.1	+	3	788	c.531C>T	c.(529-531)ttC>ttT	p.F177F	OR2W3_ENST00000360358.3_Silent_p.F177F			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGGACCACTTCCTGCGTGAGA	0.647000													18	94					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997965	115997965	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:115997965C>T	ENST00000264363.2	-	2	906	c.228G>A	c.(226-228)acG>acA	p.T76T		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	76	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CAGTAGGGTCCGTTTTGGATG	0.418000													41	81					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72351061	72351061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72351061C>T	ENST00000389916.4	+	19	2985	c.2847C>T	c.(2845-2847)ctC>ctT	p.L949L		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	949					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						AAGTCAAACTCCCTCCAAGCC	0.612000													3	7					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1657262	1657262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1657262G>A	ENST00000426508.2	-	3	369	c.6C>T	c.(4-6)gcC>gcT	p.A2A	IFT140_ENST00000439987.2_5'UTR|LA16c-395F10.2_ENST00000563162.1_RNA	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	2										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				CATAATAGAGGGCCATGACGG	0.468000													27	80					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120969584	120969584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120969584C>T	ENST00000273666.6	+	15	1686	c.1415C>T	c.(1414-1416)tCa>tTa	p.S472L	STXBP5L_ENST00000471454.1_Missense_Mutation_p.S472L|STXBP5L_ENST00000492541.1_Missense_Mutation_p.S472L|STXBP5L_ENST00000497029.1_Missense_Mutation_p.S472L|STXBP5L_ENST00000472879.1_Missense_Mutation_p.S472L	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	472					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		GCAGATGGATCAATAAAATTT	0.294000													12	33					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52554257	52554257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52554257G>A	ENST00000321725.6	+	52	5526	c.5450G>A	c.(5449-5451)cGa>cAa	p.R1817Q		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1817	FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGCCCACTTCGAACCATGCAT	0.622000													11	154					0	0	1	0	0
IL1B	3553	broad.mit.edu	37	2	113588899	113588899	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113588899C>T	ENST00000263341.2	-	6	777	c.567G>A	c.(565-567)ttG>ttA	p.L189L	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	189					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	TATCATCTTTCAACACGCAGG	0.468000													69	166					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54894327	54894327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54894327G>A	ENST00000293373.6	+	3	303	c.224G>A	c.(223-225)gGa>gAa	p.G75E	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.G25E	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	75					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CAACATTTAGGACCAGTACAT	0.373000													57	139					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15547702	15547702	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15547702G>A	ENST00000389282.4	-	4	2724	c.2511C>T	c.(2509-2511)ttC>ttT	p.F837F	WIZ_ENST00000263381.6_Silent_p.F148F|WIZ_ENST00000595214.2_5'UTR			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	837						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						GGGAGGTCAGGAAGCTGCCAG	0.682000													7	29					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1387776	1387776	+	Missense_Mutation	SNP	C	C	T	rs144852834	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1387776C>T	ENST00000378785.2	+	3	1179	c.184C>T	c.(184-186)Cgt>Tgt	p.R62C		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	62							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGAAGGATTCCGTGCCTTTGT	0.577000													33	85					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24902212	24902212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24902212G>A	ENST00000347898.3	+	9	1309	c.687G>A	c.(685-687)atG>atA	p.M229I	SLC5A11_ENST00000569071.1_Intron|SLC5A11_ENST00000545376.1_Missense_Mutation_p.M159I|SLC5A11_ENST00000565769.1_Missense_Mutation_p.M165I|SLC5A11_ENST00000449109.2_Intron|SLC5A11_ENST00000539472.1_Missense_Mutation_p.M165I|SLC5A11_ENST00000424767.2_Missense_Mutation_p.M194I|SLC5A11_ENST00000568579.1_Missense_Mutation_p.M159I|SLC5A11_ENST00000567758.1_Missense_Mutation_p.M194I	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	229					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		TTGGTGGGATGGAAGGACTGA	0.547000													53	164					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41949551	41949551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41949551C>T	ENST00000298919.7	+	7	962	c.574C>T	c.(574-576)Cgg>Tgg	p.R192W	PDZRN4_ENST00000539469.2_Missense_Mutation_p.R194W|PDZRN4_ENST00000402685.2_Missense_Mutation_p.R452W			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	452							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AGAAGGGGATCGGATTTTGCA	0.408000													19	106					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48312324	48312324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48312324C>T	ENST00000435803.1	+	17	3085	c.3061C>T	c.(3061-3063)Ctt>Ttt	p.L1021F		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1021					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AGCAGAGGTTCTTGGGGGAAT	0.343000													9	18					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16894480	16894480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16894480C>T	ENST00000430580.2	-	24	3547	c.2660G>A	c.(2659-2661)gGt>gAt	p.G887D	NBPF1_ENST00000432949.1_Silent_p.R290R|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	887	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCACCTGGGACCTGTTGCCTC	0.438000													39	487					0	0	1	0	0
LUC7L3	51747	broad.mit.edu	37	17	48823102	48823102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48823102G>A	ENST00000505658.1	+	8	904	c.715G>A	c.(715-717)Gaa>Aaa	p.E239K	LUC7L3_ENST00000544170.1_Missense_Mutation_p.E163K|LUC7L3_ENST00000393227.2_Missense_Mutation_p.E239K|LUC7L3_ENST00000240304.1_Missense_Mutation_p.E239K			O95232	LC7L3_HUMAN	LUC7-like 3 (S. cerevisiae)	239	Arg/Ser-rich.|Glu-rich.				apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	12						GAAAAGAACCGAAGAACCTGA	0.348000													6	49					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120385964	120385964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120385964G>A	ENST00000331113.4	+	5	2563	c.1598G>A	c.(1597-1599)cGa>cAa	p.R533Q		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	533					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TGTTCACGACGACACAAAAAA	0.448000													35	84					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201687649	201687649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201687649C>T	ENST00000367296.4	+	3	1412	c.992C>T	c.(991-993)cCc>cTc	p.P331L	NAV1_ENST00000367300.3_Missense_Mutation_p.P331L|NAV1_ENST00000367297.4_Missense_Mutation_p.P331L|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000295624.6_Missense_Mutation_p.P331L|NAV1_ENST00000367302.1_Missense_Mutation_p.P344L	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	331					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						GGTGACGCGCCCTCTGTGGGT	0.697000													13	26					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885322	24885322	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24885322G>A	ENST00000382554.3	+	9	4685	c.4367G>A	c.(4366-4368)tGg>tAg	p.W1456*		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1456					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GGGCAGTGGTGGAGTTTGCCA	0.602000													25	40					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065620	55065620	+	RNA	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55065620G>C	ENST00000526016.1	-	0	88					NR_038174.2																						TGTCTTGCCAGTTGAGGTAGA	0.493000													15	47					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5664387	5664387	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5664387G>A	ENST00000354852.5	+	14	2150	c.1977G>A	c.(1975-1977)ctG>ctA	p.L659L	TRIM34_ENST00000495668.1_3'UTR|HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000514226.1_Silent_p.L305L|TRIM6-TRIM34_ENST00000457787.2_Silent_p.L305L|TRIM34_ENST00000429814.2_Silent_p.L305L	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		659						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		ATGTCACACTGAATTCAGTCA	0.318000													6	14					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48598515	48598515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48598515C>T	ENST00000323776.5	+	8	1252	c.1090C>T	c.(1090-1092)Cgg>Tgg	p.R364W	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.R327W	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	327					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CACCTGGGATCGGAGTCTGTT	0.567000													10	20					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108813853	108813853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108813853C>T	ENST00000232603.5	-	7	568	c.486G>A	c.(484-486)caG>caA	p.Q162Q	MORC1_ENST00000483760.1_Silent_p.Q162Q	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	162					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTGCAAATTTCTGGGGATCAT	0.323000													17	54					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60785797	60785797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60785797C>T	ENST00000313421.7	+	12	2060	c.1874C>T	c.(1873-1875)tCc>tTc	p.S625F	CD6_ENST00000344028.5_Missense_Mutation_p.S593F|CD6_ENST00000452451.2_Intron|CD6_ENST00000352009.5_Intron|CD6_ENST00000346437.4_Missense_Mutation_p.S552F	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	625					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						AGCACCTCATCCGGGGAGTGG	0.622000													8	19					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14791399	14791399	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14791399G>A	ENST00000358984.4	+	16	1914		c.e16-1		ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Splice_Site	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B											breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ACTTTTAACAGAGTCCCTGTG	0.299000													13	72					0	0	1	0	0
PRTFDC1	56952	broad.mit.edu	37	10	25226182	25226182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25226182C>T	ENST00000320152.6	-	3	298	c.270G>A	c.(268-270)aaG>aaA	p.K90K	PRTFDC1_ENST00000376376.3_Silent_p.K90K|PRTFDC1_ENST00000376378.1_Silent_p.K90K	NM_020200.5	NP_064585.1	Q9NRG1	PRDC1_HUMAN	phosphoribosyl transferase domain containing 1	90					adenine salvage|central nervous system neuron development|cerebral cortex neuron differentiation|cytolysis|dendrite morphogenesis|GMP salvage|grooming behavior|hypoxanthine metabolic process|IMP salvage|lymphocyte proliferation|positive regulation of dopamine metabolic process|purine ribonucleoside salvage|response to amphetamine|striatum development	cytosol	hypoxanthine phosphoribosyltransferase activity|magnesium ion binding|nucleotide binding|protein homodimerization activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	9						GGCTGATGTTCTTAAGGTGTT	0.373000													36	83					0	0	1	0	0
IPO9	55705	broad.mit.edu	37	1	201840306	201840306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201840306C>T	ENST00000361565.4	+	19	2496	c.2427C>T	c.(2425-2427)ttC>ttT	p.F809F		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	809					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						TCATGGTGTTCGCTCATCTGG	0.483000													55	134					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179737040	179737040	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179737040C>T	ENST00000420890.2	-	13	2017		c.e13-1		CCDC141_ENST00000295723.5_Splice_Site	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141								protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TCTCTTTTGCCTGTTAAATTA	0.338000													18	50					0	0	1	0	0
GPR22	2845	broad.mit.edu	37	7	107115577	107115577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107115577G>A	ENST00000304402.4	+	3	2415	c.1072G>A	c.(1072-1074)Gga>Aga	p.G358R	COG5_ENST00000347053.3_Intron|COG5_ENST00000475638.2_Intron|COG5_ENST00000297135.3_Intron|COG5_ENST00000393603.2_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	358						integral to plasma membrane	G-protein coupled receptor activity			large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						CATGGCTTATGGAACAACTAT	0.313000													40	92					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110829374	110829374	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110829374G>A	ENST00000375820.4	-	34	2848	c.2727C>T	c.(2725-2727)ggC>ggT	p.G909G		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	909	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGCCCGGAAAGCCATGGTCCC	0.592000													18	49					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587231	247587231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247587231G>A	ENST00000366497.2	+	4	1266	c.486G>A	c.(484-486)gtG>gtA	p.V162V	NLRP3_ENST00000391828.3_Silent_p.V162V|NLRP3_ENST00000336119.3_Silent_p.V162V|NLRP3_ENST00000391827.2_Silent_p.V162V|NLRP3_ENST00000348069.2_Silent_p.V162V|NLRP3_ENST00000366496.2_Silent_p.V162V|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	162					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GTGAGAGTGTGAGCCTCAACA	0.532000													8	31					0	0	1	0	0
PDZD7	79955	broad.mit.edu	37	10	102789950	102789950	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102789950G>A	ENST00000370215.3	-	2	252	c.27C>T	c.(25-27)ttC>ttT	p.F9F	PDZD7_ENST00000470414.1_Silent_p.F9F	NM_024895.4	NP_079171.1	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	9						cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CCAGTGGGTCGAAGCCCACTG	0.667000													4	16					0	0	1	0	0
DCST2	127579	broad.mit.edu	37	1	155002584	155002584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155002584C>T	ENST00000368424.3	-	7	1211	c.1153G>A	c.(1153-1155)Gag>Aag	p.E385K	DCST2_ENST00000295536.5_Missense_Mutation_p.E385K	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	385						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CGCCTGGCCTCGTGAGCACTG	0.652000													27	57					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40566414	40566414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40566414C>T	ENST00000560346.1	+	10	2398	c.1815C>T	c.(1813-1815)tcC>tcT	p.S605S	PAK6_ENST00000441369.1_Silent_p.S605S|PAK6_ENST00000453867.1_Silent_p.S605S|PAK6_ENST00000260404.4_Silent_p.S605S|PAK6_ENST00000542403.2_Silent_p.S605S|PAK6_ENST00000455577.2_Intron|RP11-133K1.2_ENST00000558658.1_3'UTR			Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	605	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		TCAGTGACTCCCCAGTGCAAG	0.572000											OREG0023057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	104					0	0	1	0	0
SLC29A3	55315	broad.mit.edu	37	10	73104007	73104007	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73104007C>A	ENST00000373189.5	+	3	394	c.342C>A	c.(340-342)ccC>ccA	p.P114P		NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	114					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						CCACCGTGCCCTCCATGCTGT	0.587000													25	64					2.41591e-17	2.42948e-17	1	1	0
MOV10	4343	broad.mit.edu	37	1	113234340	113234340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113234340C>T	ENST00000369644.1	+	7	1751	c.722C>T	c.(721-723)cCt>cTt	p.P241L	MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000413052.2_Missense_Mutation_p.P297L|MOV10_ENST00000369645.1_Missense_Mutation_p.P297L|MOV10_ENST00000357443.2_Missense_Mutation_p.P297L			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	297					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TACTACCCACCTCCCCGCCTC	0.542000													33	96					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269119	30269119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:30269119C>T	ENST00000378981.3	+	4	830	c.509C>T	c.(508-510)cCt>cTt	p.P170L	MAGEB1_ENST00000397548.2_Missense_Mutation_p.P170L|MAGEB1_ENST00000397550.1_Missense_Mutation_p.P170L	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	170	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						GAAGACAACCCTAGTGGCCAC	0.493000													10	8					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4827821	4827821	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4827821C>T	ENST00000268231.8	-	10	1317	c.1054G>A	c.(1054-1056)Gac>Aac	p.D352N	SEPT12_ENST00000396693.5_Missense_Mutation_p.D306N	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	352					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						TCAGAATCGTCATGGGCCCCC	0.672000													3	4					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32264549	32264549	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32264549G>A	ENST00000343380.5	-	7	1442	c.1303C>T	c.(1303-1305)Ctg>Ttg	p.L435L		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	435	Transactivation.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						CAGAAATCCAGGGGGGTGAGG	0.642000													3	14					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330444	125330444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125330444G>A	ENST00000304865.2	-	1	394	c.313C>T	c.(313-315)Ctc>Ttc	p.L105F		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						AAGGCATAGAGAAAATACATC	0.488000													28	52					0	0	1	0	0
ELL	8178	broad.mit.edu	37	19	18572511	18572511	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18572511G>A	ENST00000262809.4	-	5	692	c.621C>T	c.(619-621)ttC>ttT	p.F207F		NM_006532.3	NP_006523.1	P55199	ELL_HUMAN	elongation factor RNA polymerase II	207					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(5)|prostate(1)	19				GBM - Glioblastoma multiforme(1328;7.81e-07)		CTCGGTCACGGAAGGGCCTCT	0.672000			T	MLL	AL						OREG0025366	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	52					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103311564	103311564	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103311564G>A	ENST00000233969.2	+	7	1720	c.1578G>A	c.(1576-1578)tgG>tgA	p.W526*	SLC9A2_ENST00000469286.1_3'UTR	NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	526						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						ACAACTTTTGGAGAGACAAGT	0.368000													39	156					0	0	1	0	0
CSE1L	1434	broad.mit.edu	37	20	47700684	47700684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47700684C>T	ENST00000262982.2	+	15	1727	c.1604C>T	c.(1603-1605)cCt>cTt	p.P535L	CSE1L_ENST00000542325.1_Missense_Mutation_p.P318L|CSE1L_ENST00000396192.3_Missense_Mutation_p.P479L	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	535					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			ATGCGAGGGCCTAACAATGCC	0.403000													18	109					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35910131	35910131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35910131C>T	ENST00000397367.2	-	4	488	c.362G>A	c.(361-363)aGa>aAa	p.R121K	CAPSL_ENST00000514524.1_Missense_Mutation_p.R121K|CAPSL_ENST00000397366.1_Missense_Mutation_p.R121K	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	121	EF-hand 3.					cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			GTCTAACTTTCTAAAAGCTTG	0.378000													29	96					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112732956	112732956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:112732956G>A	ENST00000295408.4	+	7	1308	c.1051G>A	c.(1051-1053)Gcc>Acc	p.A351T	MERTK_ENST00000409780.1_Missense_Mutation_p.A175T|MERTK_ENST00000421804.2_Missense_Mutation_p.A351T			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	351	Fibronectin type-III 1.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						GCAGCTGCAAGCCCTGGCTAA	0.473000													63	142					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	425526	425526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:425526G>A	ENST00000256509.2	+	19	2846	c.2204G>A	c.(2203-2205)aGg>aAg	p.R735K	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Missense_Mutation_p.R719K	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	719	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAAAACATAAGGGTTCAAGCC	0.353000													28	72					0	0	1	0	0
TSSK4	283629	broad.mit.edu	37	14	24675162	24675162	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24675162A>G	ENST00000339917.5	+	1	237	c.33A>G	c.(31-33)ccA>ccG	p.P11P	TSSK4_ENST00000428351.2_Silent_p.P11P|TSSK4_ENST00000556621.1_Intron|TSSK4_ENST00000287913.6_Silent_p.P11P|TM9SF1_ENST00000530611.1_Intron|TM9SF1_ENST00000556387.1_Intron	NM_001184739.1|NM_174944.3	NP_001171668.1|NP_777604.2	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	11					cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	8				GBM - Glioblastoma multiforme(265;0.018)		AGGCAGCACCAACCACCACAG	0.522000													16	64					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232666	21232666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21232666C>T	ENST00000233242.1	-	26	7201	c.7074G>A	c.(7072-7074)atG>atA	p.M2358I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2358					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTAATTTATCCATTAAAACCT	0.373000													14	60					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153417432	153417432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:153417432G>A	ENST00000288670.9	+	6	846	c.479G>A	c.(478-480)aGc>aAc	p.S160N		NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	160	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						ACTGTGGAGAGCTCGGTGGAC	0.473000													6	14					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36952410	36952410	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36952410G>A	ENST00000262865.4	+	8	996	c.907G>A	c.(907-909)Gag>Aag	p.E303K	CTD-2308N23.2_ENST00000437016.1_RNA|BPI_ENST00000489102.1_3'UTR	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	303					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				TGTATACCAAGAGGCTGGGGT	0.562000													11	43					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13366056	13366056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13366056G>A	ENST00000360228.5	-	29	4607	c.4608C>T	c.(4606-4608)ttC>ttT	p.F1536F	CACNA1A_ENST00000573710.2_Silent_p.F1537F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1537					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGCTGATGGCGAAATCAATGC	0.612000													4	16					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78846280	78846280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:78846280G>A	ENST00000286627.5	-	11	2358	c.1406C>T	c.(1405-1407)tCc>tTc	p.S469F	KCNMA1_ENST00000372440.1_Missense_Mutation_p.S469F|KCNMA1_ENST00000354353.5_Missense_Mutation_p.S469F|KCNMA1_ENST00000404857.1_Missense_Mutation_p.S469F|KCNMA1_ENST00000406533.3_Missense_Mutation_p.S469F|KCNMA1_ENST00000286628.8_Missense_Mutation_p.S469F|KCNMA1_ENST00000404771.3_Missense_Mutation_p.S469F|KCNMA1_ENST00000372443.1_Missense_Mutation_p.S469F	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	469	RCK N-terminal.				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	ATTGAGGACGGAACCCTGATA	0.473000													20	56					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126224649	126224649	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126224649G>A	ENST00000290868.2	-	8	761	c.708C>T	c.(706-708)atC>atT	p.I236I	UROC1_ENST00000383579.3_Silent_p.I236I	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	236					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CCAAGTCCTCGATGCCCAGGT	0.647000													15	41					0	0	1	0	0
WNT7B	7477	broad.mit.edu	37	22	46318801	46318801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46318801G>A	ENST00000339464.4	-	4	1359	c.985C>T	c.(985-987)Cac>Tac	p.H329Y	WNT7B_ENST00000410089.1_Missense_Mutation_p.H313Y|WNT7B_ENST00000409496.3_Missense_Mutation_p.H333Y	NM_058238.2	NP_478679.1	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family, member 7B	329					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	19		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCACCAGTGGAATTTGCAG	0.657000													27	73					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128855915	128855915	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128855915G>A	ENST00000310343.9	-	14	1466	c.1467C>T	c.(1465-1467)ctC>ctT	p.L489L	ARHGAP32_ENST00000527272.1_Silent_p.L140L|ARHGAP32_ENST00000392657.3_Silent_p.L140L|ARHGAP32_ENST00000524655.1_Silent_p.L415L	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	489	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GTGGTGGGGGGAGCTGCTGGA	0.438000													8	35					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24533775	24533775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24533775G>A	ENST00000357578.3	+	10	1588	c.1443G>A	c.(1441-1443)gtG>gtA	p.V481V	ALDH5A1_ENST00000491546.1_Silent_p.V453V|ALDH5A1_ENST00000546278.1_Silent_p.V393V|ALDH5A1_ENST00000348925.2_Silent_p.V494V	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	481					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TCTGGAGAGTGGCAGAGCAGC	0.488000													32	97					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50144242	50144242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50144242C>T	ENST00000347869.3	+	11	1073	c.898C>T	c.(898-900)Cct>Tct	p.P300S		NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	300	RRM 2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTCCATCCTCCTTTGAAAAT	0.388000													33	74					0	0	1	0	0
TBX21	30009	broad.mit.edu	37	17	45820503	45820503	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45820503C>T	ENST00000177694.1	+	3	924	c.713C>T	c.(712-714)tCa>tTa	p.S238L		NM_013351.1	NP_037483.1	Q9UL17	TBX21_HUMAN	T-box 21	238					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|endometrium(1)|large_intestine(3)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	22						CAGGAAGTTTCATTTGGGAAA	0.572000													23	44					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964834	119964834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119964834G>A	ENST00000543831.1	+	4	959	c.710G>A	c.(709-711)aGg>aAg	p.R237K	HSD3B2_ENST00000369416.3_Missense_Mutation_p.R237K	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	237			Missing (in AH2; activity abolished).		androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CTGGCCTTGAGGGCTCTGCGG	0.507000													12	94					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53201637	53201637	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53201637A>G	ENST00000551956.1	-	7	1629	c.1137T>C	c.(1135-1137)ctT>ctC	p.L379L	KRT4_ENST00000458244.2_Silent_p.L359L|KRT4_ENST00000293774.4_Silent_p.L453L			B4DRS2	B4DRS2_HUMAN	keratin 4	379						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CGGATACCTGAAGAGTCTGGC	0.577000													6	51					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167504	140167504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140167504G>A	ENST00000458420.3	+	6	1121	c.931G>A	c.(931-933)Gac>Aac	p.D311N		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	311					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GAAGGGTTGTGACCGGGAGAC	0.463000										HNSCC(16;0.037)			36	93					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255505	15255505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15255505C>T	ENST00000378116.4	-	8	2088	c.2082G>A	c.(2080-2082)atG>atA	p.M694I		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	694						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CCCCAAGCTCCATCAGGGCCT	0.582000													37	89					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89789189	89789189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89789189C>T	ENST00000289816.5	+	2	543	c.231C>T	c.(229-231)tcC>tcT	p.S77S	ZNF276_ENST00000446326.2_5'UTR|ZNF276_ENST00000568064.1_Silent_p.S77S|ZNF276_ENST00000443381.2_Silent_p.S152S	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TTCTCAAGTCCTTCCTGCAGA	0.607000													40	79					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26663466	26663466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26663466G>A	ENST00000256737.3	+	22	3017	c.2165G>A	c.(2164-2166)cGa>cAa	p.R722Q	ANO3_ENST00000537978.1_Missense_Mutation_p.R706Q|ANO3_ENST00000525139.1_Missense_Mutation_p.R706Q|ANO3_ENST00000531568.1_Missense_Mutation_p.R576Q	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	722						chloride channel complex	chloride channel activity	p.R722Q(1)		breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						TGGTGGTCACGACATAAAATC	0.428000													22	88					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760565	92760565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92760565C>T	ENST00000318238.4	-	5	5936	c.4720G>A	c.(4720-4722)Gaa>Aaa	p.E1574K	SAMD9L_ENST00000411955.1_Missense_Mutation_p.E1574K|SAMD9L_ENST00000437805.1_Missense_Mutation_p.E1574K	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1574										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGAGGGCCTTCAATGGAAAAT	0.323000													21	51					0	0	1	0	0
BCMO1	53630	broad.mit.edu	37	16	81319226	81319226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81319226C>T	ENST00000258168.2	+	9	1750	c.1289C>T	c.(1288-1290)cCa>cTa	p.P430L	BCMO1_ENST00000425577.2_Missense_Mutation_p.P361L	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	430					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						CAGTGGAGTCCAATCCCAACC	0.438000													8	61					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62757842	62757842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:62757842C>T	ENST00000281156.4	-	3	555	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	93	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		CCTGTTTCTTCCTGTAGCCTC	0.373000													42	143					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504631	70504631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70504631G>A	ENST00000310961.5	+	22	3443	c.3025G>A	c.(3025-3027)Gat>Aat	p.D1009N	LRRC7_ENST00000035383.5_Missense_Mutation_p.D1004N|LRRC7_ENST00000415775.2_Missense_Mutation_p.D288N			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1004						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCCAATGCTGGATGATGAGAT	0.468000													16	55					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240849	126240849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126240849G>A	ENST00000394329.3	+	1	3296	c.3283G>A	c.(3283-3285)Gat>Aat	p.D1095N		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1095	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGATGTAAATGATAACAGACC	0.383000													72	177					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127777	152127777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152127777C>T	ENST00000316073.3	-	3	1862	c.1798G>A	c.(1798-1800)Ggg>Agg	p.G600R		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	600	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CCTTCAGTCCCTTGGAAGTAC	0.458000													102	263					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33700343	33700343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33700343G>A	ENST00000336934.5	-	7	2073	c.1957C>T	c.(1957-1959)Ccc>Tcc	p.P653S	STARD13_ENST00000255486.4_Missense_Mutation_p.P645S|STARD13_ENST00000399365.3_Missense_Mutation_p.P535S	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	653					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TTGTAGTCGGGAACTTTCATC	0.498000													61	162					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60212997	60212997	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:60212997G>A	ENST00000267484.5	-	2	779	c.444C>T	c.(442-444)ccC>ccT	p.P148P		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	148					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		CTGGTAAGGAGGGGCCGGGTG	0.488000													17	52					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286797	152286797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152286797C>T	ENST00000368799.1	-	3	600	c.565G>A	c.(565-567)Gaa>Aaa	p.E189K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	189					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTAGTATTTTCAGTCTTGTTT	0.308000									Ichthyosis				9	80					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140043562	140043562	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140043562G>A	ENST00000371561.3	+	4	1768		c.e4+1		GRIN1_ENST00000371553.3_Splice_Site|GRIN1_ENST00000315048.3_Splice_Site|GRIN1_ENST00000471122.1_Splice_Site|GRIN1_ENST00000350902.5_Splice_Site|GRIN1_ENST00000371546.4_Splice_Site|GRIN1_ENST00000371555.4_Splice_Site|GRIN1_ENST00000371559.4_Splice_Site|GRIN1_ENST00000371550.4_Splice_Site|GRIN1_ENST00000371560.3_Splice_Site	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1						ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	TTTCTGCCAGGTGAGGCTGGG	0.602000													7	9					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110821999	110821999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110821999C>T	ENST00000375820.4	-	43	3974	c.3853G>A	c.(3853-3855)Gac>Aac	p.D1285N		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1285	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AATCCAGGGTCTCCCTTGGGC	0.498000													8	120					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6955364	6955364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6955364G>A	ENST00000389658.3	-	57	8288	c.8195C>T	c.(8194-8196)gCt>gTt	p.A2732V	RP11-781P6.1_ENST00000584722.1_RNA	NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2732	Laminin G-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTTTCTGACAGCCGACTGATT	0.478000													4	28					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143772241	143772241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143772241C>T	ENST00000408898.2	+	1	967	c.929C>T	c.(928-930)tCa>tTa	p.S310L		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					AAGAGAACTTCATGAAAGCCT	0.398000													63	176					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1755004	1755004	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1755004C>T	ENST00000397196.2	+	5	898	c.666C>T	c.(664-666)gtC>gtT	p.V222V	WNT5B_ENST00000310594.3_Silent_p.V222V|WNT5B_ENST00000545747.1_3'UTR|WNT5B_ENST00000537031.1_Silent_p.V222V|WNT5B_ENST00000542408.1_3'UTR	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	222					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			GCCACGGCGTCTCGGGGTCCT	0.617000													18	78					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98312019	98312019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98312019G>A	ENST00000264193.2	-	1	548	c.330C>T	c.(328-330)gcC>gcT	p.A110A		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	110						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CCAGCGAAGTGGCCCGCGTCC	0.726000													8	15					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740549	37740549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37740549C>T	ENST00000539465.1	+	15	2617	c.2024C>T	c.(2023-2025)tCc>tTc	p.S675F	FRMPD1_ENST00000377765.3_Missense_Mutation_p.S675F|FRMPD1_ENST00000541302.1_Missense_Mutation_p.S544F|FRMPD1_ENST00000536622.1_Missense_Mutation_p.S497F|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	675						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		ACAGAGTTTTCCGAGAGTGCT	0.582000													6	37					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106110258	106110258	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106110258G>A	ENST00000390545.2	-	0	359																											GGGGGAAGAGGAAGACTGACG	0.622000													23	78					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32059435	32059435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:32059435C>T	ENST00000438447.1	+	13	2679	c.2291C>T	c.(2290-2292)tCa>tTa	p.S764L	PDZD2_ENST00000282493.3_Missense_Mutation_p.S764L			O15018	PDZD2_HUMAN	PDZ domain containing 2	764	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GCTCCAGGATCAGTGGCCAAG	0.463000													26	39					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130409573	130409573	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130409573C>T	ENST00000370904.1	-	22	3946	c.3036G>A	c.(3034-3036)ggG>ggA	p.G1012G	IGSF1_ENST00000370903.3_Silent_p.G1026G|IGSF1_ENST00000370910.1_Silent_p.G1012G|IGSF1_ENST00000361420.3_Silent_p.G1021G			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1021	Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TGGGGAATGCCCCGTCATTAC	0.522000													10	42					0	0	1	0	0
CLEC7A	64581	broad.mit.edu	37	12	10275908	10275908	+	Missense_Mutation	SNP	G	G	A	rs140318683	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10275908G>A	ENST00000353231.5	-	4	567	c.409C>T	c.(409-411)Ctt>Ttt	p.L137F	CLEC7A_ENST00000396484.2_Missense_Mutation_p.L104F|CLEC7A_ENST00000304084.8_Missense_Mutation_p.L183F|CLEC7A_ENST00000533022.1_Intron|CLEC7A_ENST00000298523.5_Intron	NM_022570.4	NP_072092.2	Q9BXN2	CLC7A_HUMAN	C-type lectin domain family 7, member A	183	C-type lectin.				carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						GGCCGAGAAAGGCCTATCCAA	0.388000													10	48					0	0	1	0	0
GPR176	11245	broad.mit.edu	37	15	40099395	40099395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40099395G>A	ENST00000299092.3	-	3	432	c.234C>T	c.(232-234)ttC>ttT	p.F78F	GPR176_ENST00000543580.1_Silent_p.F34F|GPR176_ENST00000561100.1_Silent_p.F79F|GPR176_ENST00000560729.1_5'UTR	NM_001271854.1|NM_001271855.1	NP_001258783.1|NP_001258784.1	Q14439	GP176_HUMAN	G protein-coupled receptor 176	79					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)	23		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		GGTTTTTAATGAACCTGTTGG	0.453000													52	121					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36402445	36402445	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36402445C>T	ENST00000255448.4	-	9	1441		c.e9-1		DCLK1_ENST00000379893.1_Splice_Site|DCLK1_ENST00000360631.3_Splice_Site	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1						cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		AGCAGTCGATCTGCGAAGAGA	0.323000													15	29					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85518140	85518140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:85518140G>A	ENST00000393217.2	+	17	3911	c.3850G>A	c.(3850-3852)Gaa>Aaa	p.E1284K		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1284										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CGCCACATGTGAAAATATGGA	0.448000													66	121					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184175043	184175043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:184175043C>T	ENST00000403733.3	+	9	1286	c.1087C>T	c.(1087-1089)Cca>Tca	p.P363S	WWC2_ENST00000504005.1_Missense_Mutation_p.P45S|WWC2_ENST00000378925.3_Missense_Mutation_p.P265S|WWC2_ENST00000448232.2_Missense_Mutation_p.P363S|WWC2_ENST00000513834.1_Missense_Mutation_p.P363S	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	363										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		GTTCGTCACCCCACAGAAACG	0.483000													4	24					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3658762	3658762	+	Silent	SNP	C	C	T	rs146442815		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:3658762C>T	ENST00000404826.2	+	2	488	c.349C>T	c.(349-351)Ctg>Ttg	p.L117L	SDK1_ENST00000389531.3_Silent_p.L117L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	117	Ig-like C2-type 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACAGATCCACCTGGAAGGGAA	0.473000													12	24					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101748012	101748012	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101748012G>A	ENST00000375001.3	+	3	689	c.266G>A	c.(265-267)aGg>aAg	p.R89K		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	89	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				ACCTTCTTCAGGGACTTCGCC	0.612000													11	57					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72360381	72360381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72360381G>A	ENST00000441259.1	-	2	438	c.278C>T	c.(277-279)aCc>aTc	p.T93I	PRF1_ENST00000373209.2_Missense_Mutation_p.T93I	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	93	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						CCGCCAGTTGGTGAGCGCCAG	0.662000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				12	23					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42875928	42875928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:42875928C>T	ENST00000025301.2	+	8	3221	c.3046C>T	c.(3046-3048)Cat>Tat	p.H1016Y		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1016					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTCTATGGTTCATGGATCCTC	0.423000													23	84					0	0	1	0	0
PURG	29942	broad.mit.edu	37	8	30889719	30889719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30889719G>A	ENST00000475541.1	-	1	1512	c.580C>T	c.(580-582)Cgc>Tgc	p.R194C	PURG_ENST00000339382.2_Missense_Mutation_p.R194C	NM_013357.2	NP_037489.1	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G	194						nucleus	DNA binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CGTAGGAAGCGACCCCGCTGA	0.488000													29	83					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62763577	62763577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62763577G>A	ENST00000336232.2	-	6	944	c.809C>T	c.(808-810)tCg>tTg	p.S270L	SLC22A8_ENST00000311438.8_Missense_Mutation_p.S270L|SLC22A8_ENST00000542795.1_5'UTR|SLC22A8_ENST00000545207.1_Missense_Mutation_p.S179L|SLC22A8_ENST00000535878.1_Missense_Mutation_p.S147L|SLC22A8_ENST00000430500.2_Missense_Mutation_p.S270L	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	270					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CAGGGCCTTCGAGGACTTTCC	0.577000													31	84					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009703	9009703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9009703G>A	ENST00000397910.4	-	39	39226	c.39023C>T	c.(39022-39024)cCt>cTt	p.P13008L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13010					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACCAGGAGAGGAACAGCTGC	0.453000													37	111					0	0	1	0	0
TTC38	55020	broad.mit.edu	37	22	46669961	46669961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46669961C>T	ENST00000381031.3	+	4	436	c.360C>T	c.(358-360)gcC>gcT	p.A120A	TTC38_ENST00000445282.2_Silent_p.A120A	NM_017931.2	NP_060401.2	Q5R3I4	TTC38_HUMAN	tetratricopeptide repeat domain 38	120							binding			endometrium(4)|large_intestine(3)|lung(4)|ovary(1)	12						AGACATTTGCCAATGGGTGAG	0.622000													18	37					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51993386	51993386	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51993386G>A	ENST00000220478.3	+	10	1555	c.1152G>A	c.(1150-1152)aaG>aaA	p.K384K	SCG3_ENST00000542355.2_Silent_p.K152K	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	384					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		GAAGCTTGAAGGATTCCACAA	0.423000													34	83					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208218435	208218435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:208218435G>A	ENST00000367033.3	-	19	4373	c.3616C>T	c.(3616-3618)Ctc>Ttc	p.L1206F		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1206	IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TGCCCGGTGAGGTTGGGAGGC	0.582000													23	59					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130778016	130778016	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:130778016G>A	ENST00000276708.4	-	4	1309	c.428C>T	c.(427-429)tCa>tTa	p.S143L		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	143						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CTTCAGAAATGATGGCTCTGG	0.502000													19	44					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30858825	30858825	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30858825C>T	ENST00000324771.8	+	7	1041	c.493C>T	c.(493-495)Cgc>Tgc	p.R165C	DDR1_ENST00000418800.2_Missense_Mutation_p.R165C|DDR1_ENST00000376570.4_Missense_Mutation_p.R165C|DDR1_ENST00000376569.3_Missense_Mutation_p.R165C|DDR1_ENST00000376567.2_Missense_Mutation_p.R165C|DDR1_ENST00000452441.1_Missense_Mutation_p.R165C|DDR1_ENST00000376568.3_Missense_Mutation_p.R165C|DDR1_ENST00000508312.1_Missense_Mutation_p.R183C|DDR1_ENST00000508472.1_3'UTR|DDR1_ENST00000454612.2_Missense_Mutation_p.R165C|DDR1_ENST00000446312.1_Missense_Mutation_p.R165C|DDR1_ENST00000513240.1_Missense_Mutation_p.R165C|DDR1_ENST00000376575.3_Missense_Mutation_p.R165C			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	165	F5/8 type C.			R -> H (in Ref. 14; AAH70070).	cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CCGACTGGTTCGCTTCTACCC	0.632000													17	59					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56663310	56663310	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56663310C>T	ENST00000389934.3	-	18	3039	c.2922G>A	c.(2920-2922)agG>agA	p.R974R	TEX14_ENST00000240361.8_Silent_p.R980R|TEX14_ENST00000349033.5_Silent_p.R974R	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	980						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTCTGGGCTCCTAATGGGGG	0.517000													58	121					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22133704	22133704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22133704G>A	ENST00000408935.1	+	1	408	c.408G>A	c.(406-408)atG>atA	p.M136I		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CCAATGTGATGAACATGAGAG	0.483000													69	126					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32705074	32705074	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:32705074T>A	ENST00000531481.1	-	7	713	c.437A>T	c.(436-438)aAa>aTa	p.K146I	CCDC73_ENST00000534415.1_Intron|CCDC73_ENST00000335185.5_Intron			Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	146										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					GTTTTGTAATTTCCTTACCAT	0.289000													12	33					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788508	42788508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42788508C>T	ENST00000372980.3	-	2	1791	c.919G>A	c.(919-921)Gaa>Aaa	p.E307K		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	307					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CTGGAGCGTTCGCTCACGCCG	0.677000													7	49					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742318	23742318	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23742318G>A	ENST00000255890.4	-	0	891																											CCCAGCACGGGACTGAAGCTG	0.677000													8	31					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65274970	65274970	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:65274970G>A	ENST00000381210.3	-	1	210	c.100C>T	c.(100-102)Cac>Tac	p.H34Y	TECRL_ENST00000507440.1_Missense_Mutation_p.H34Y	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	34					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						GACAAAAAGTGAAAATTTCTC	0.413000													29	71					0	0	1	0	0
UBA3	9039	broad.mit.edu	37	3	69111302	69111302	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:69111302G>A	ENST00000361055.4	-	10	776	c.722C>T	c.(721-723)tCt>tTt	p.S241F	UBA3_ENST00000415609.2_Missense_Mutation_p.S200F|UBA3_ENST00000349511.4_Missense_Mutation_p.S227F|UBA3_ENST00000540295.1_Missense_Mutation_p.S64F	NM_003968.3	NP_003959.3	Q8TBC4	UBA3_HUMAN	ubiquitin-like modifier activating enzyme 3	241					protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		CCTGGGCATAGATGCAATGGT	0.368000													53	119					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48414334	48414334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48414334C>T	ENST00000296438.5	+	2	263	c.77C>T	c.(76-78)tCc>tTc	p.S26F	FBXW12_ENST00000445170.1_Intron|FBXW12_ENST00000436231.1_Intron|FBXW12_ENST00000415155.1_Missense_Mutation_p.S26F	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	26	F-box.									breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGCAGGTTTCCCAGGTGAAC	0.542000													18	101					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965518	35965518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35965518C>T	ENST00000274278.3	-	4	1170	c.813G>A	c.(811-813)ttG>ttA	p.L271L	UGT3A1_ENST00000333811.4_Silent_p.L217L|UGT3A1_ENST00000507113.1_Silent_p.L237L|UGT3A1_ENST00000503189.1_Silent_p.L271L|UGT3A1_ENST00000513233.1_Intron	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	271						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTTTTTCCATCAAGCCTCCAA	0.448000													8	124					0	0	1	0	0
C12orf71	728858	broad.mit.edu	37	12	27235271	27235271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:27235271G>A	ENST00000429849.2	-	1	176	c.146C>T	c.(145-147)cCt>cTt	p.P49L		NM_001080406.1	NP_001073875.1	A8MTZ7	CL071_HUMAN	chromosome 12 open reading frame 71	49										endometrium(2)|large_intestine(1)|lung(4)|skin(1)	8						GTGGATGGAAGGACCCTTGGA	0.542000													8	34					0	0	1	0	0
ABCG5	64240	broad.mit.edu	37	2	44050043	44050043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:44050043C>T	ENST00000543989.1	-	6	1876	c.171G>A	c.(169-171)gaG>gaA	p.E57E	ABCG5_ENST00000405322.1_Silent_p.E281E|ABCG5_ENST00000260645.1_Silent_p.E452E			Q9H222	ABCG5_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 5	452	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CGTCCTGACTCTCCTGGTCGC	0.572000													11	24					0	0	1	0	0
PEX26	55670	broad.mit.edu	37	22	18562684	18562684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18562684C>T	ENST00000329627.6	+	3	481	c.275C>T	c.(274-276)gCc>gTc	p.A92V	PEX26_ENST00000399744.3_Missense_Mutation_p.A92V|PEX26_ENST00000428061.2_Missense_Mutation_p.A92V	NM_017929.5	NP_060399.1	Q7Z412	PEX26_HUMAN	peroxisomal biogenesis factor 26	92					protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			breast(1)|kidney(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						GGGATCCAGGCCCTGGCAGAA	0.522000													34	107					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11718523	11718523	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11718523G>A	ENST00000381486.2	+	6	1038	c.738G>A	c.(736-738)acG>acA	p.T246T	GREB1_ENST00000263834.5_Silent_p.T246T|GREB1_ENST00000234142.5_Silent_p.T246T|GREB1_ENST00000389825.3_Silent_p.T136T|GREB1_ENST00000381483.2_Silent_p.T246T	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	246						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TTCCTGGGACGAACCCCAGCA	0.617000													28	79					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113388681	113388681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113388681C>T	ENST00000228928.7	+	7	1737	c.1558C>T	c.(1558-1560)Cct>Tct	p.P520S	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	520	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						CCTTCAGTTTCCTGAGCAGAA	0.617000													18	52					0	0	1	0	0
IL5	3567	broad.mit.edu	37	5	131877530	131877530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131877530C>T	ENST00000231454.1	-	4	421	c.378G>A	c.(376-378)atG>atA	p.M126I		NM_000879.2	NP_000870.1	P05113	IL5_HUMAN	interleukin 5 (colony-stimulating factor, eosinophil)	126					immune response|inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of podosome assembly	extracellular space	cytokine activity|growth factor activity|interleukin-5 receptor binding			endometrium(1)|large_intestine(1)|stomach(1)|upper_aerodigestive_tract(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Pranlukast(DB01411)	ACTCGGTGTTCATTACACCAA	0.393000													20	76					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579376	44579376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44579376C>T	ENST00000289547.4	-	2	675	c.620G>A	c.(619-621)gGa>gAa	p.G207E	NPC1L1_ENST00000546276.1_Missense_Mutation_p.G207E|NPC1L1_ENST00000423141.1_Missense_Mutation_p.G207E|NPC1L1_ENST00000381160.3_Missense_Mutation_p.G207E	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	207					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GCCTGTGTCTCCCTGGAAGTT	0.632000													26	70					0	0	1	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111626048	111626048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111626048G>A	ENST00000527614.1	-	6	879	c.814C>T	c.(814-816)Cgc>Tgc	p.R272C	PPP2R1B_ENST00000311129.5_Missense_Mutation_p.R272C|PPP2R1B_ENST00000427203.2_Missense_Mutation_p.R111C|PPP2R1B_ENST00000426998.2_Missense_Mutation_p.R208C|PPP2R1B_ENST00000393055.2_Missense_Mutation_p.R145C|PPP2R1B_ENST00000341980.6_Missense_Mutation_p.R272C	NM_001177562.1|NM_002716.4	NP_001171033.1|NP_002707.3	P30154	2AAB_HUMAN	protein phosphatase 2, regulatory subunit A, beta	272							protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|liver(1)|lung(10)|prostate(1)|urinary_tract(2)	22		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		ACCATATAGCGAACGCGCCAA	0.408000													37	103					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72152307	72152307	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:72152307C>T	ENST00000555818.1	+	10	3681	c.3333C>T	c.(3331-3333)atC>atT	p.I1111I	SIPA1L1_ENST00000358550.2_Silent_p.I1111I|SIPA1L1_ENST00000381232.3_Silent_p.I1111I|SIPA1L1_ENST00000537413.1_Silent_p.I586I	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1111					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CCGCCAACATCCCTCGAAGCA	0.557000													18	47					0	0	1	0	0
EIF2AK2	5610	broad.mit.edu	37	2	37365703	37365703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37365703G>A	ENST00000233057.4	-	7	864	c.542C>T	c.(541-543)tCt>tTt	p.S181F	EIF2AK2_ENST00000405334.1_Missense_Mutation_p.S181F|EIF2AK2_ENST00000395127.2_Missense_Mutation_p.S181F	NM_001135651.2	NP_001129123.1	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 2	181					evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)	22		all_hematologic(82;0.248)				AGTAGCAAAAGAACCAGAGGA	0.368000													22	74					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17311449	17311449	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17311449C>T	ENST00000595618.1	+	26	4526	c.4372_splice	c.e26-1	p.A1458_splice	MYO9B_ENST00000397274.2_Splice_Site_p.A1458_splice|MYO9B_ENST00000594824.1_Splice_Site_p.A1458_splice	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1458	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						CCCCCTCAGCCCCCTCCGGAC	0.612000													8	15					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108178243	108178243	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108178243C>T	ENST00000273353.3	-	19	2102	c.2046G>A	c.(2044-2046)gtG>gtA	p.V682V	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	682	Actin-binding (By similarity).|Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TTATGCATCTCACAAAATGAG	0.303000													14	40					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468411	56468411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:56468411C>T	ENST00000288221.6	-	2	880	c.625G>A	c.(625-627)Gag>Aag	p.E209K		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	209						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CTCATCTGCTCCTTGAGGACA	0.458000													28	58					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131186709	131186709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:131186709G>A	ENST00000337057.3	-	17	2977	c.2796C>T	c.(2794-2796)tcC>tcT	p.S932S	EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000528282.1_Silent_p.S674S|EPB41L2_ENST00000525193.1_Silent_p.S633S|EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000527659.1_Silent_p.S738S|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000445890.2_Silent_p.S674S|EPB41L2_ENST00000368128.2_Silent_p.S932S|EPB41L2_ENST00000527411.1_Silent_p.S862S|EPB41L2_ENST00000530481.1_Silent_p.S779S|EPB41L2_ENST00000531410.1_Silent_p.S53S|EPB41L2_ENST00000529208.1_Silent_p.S862S|EPB41L2_ENST00000524581.1_Silent_p.S310S	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	932	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTGTTGACACGGACTCAGATG	0.458000													20	48					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594268	179594268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179594268C>T	ENST00000589042.1	-	64	18839	c.18615G>A	c.(18613-18615)ctG>ctA	p.L6205L	TTN_ENST00000342992.6_Silent_p.L4961L|TTN_ENST00000591111.1_Silent_p.L5888L|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5888	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACAGGCTTCAGCTCTCTGA	0.463000													15	98					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28554407	28554407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28554407C>T	ENST00000452236.2	-	1	705	c.88G>A	c.(88-90)Gaa>Aaa	p.E30K	SCAND3_ENST00000530247.1_Intron	NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	30					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						GTGTGGTCTTCTTCTTTAACC	0.502000													30	57					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563857	176563857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176563857G>A	ENST00000367662.3	+	3	2281	c.1117G>A	c.(1117-1119)Gga>Aga	p.G373R	PAPPA2_ENST00000367661.3_Missense_Mutation_p.G373R	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	373					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CACTTACGATGGACGGCACAT	0.572000													15	57					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78458947	78458947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:78458947C>T	ENST00000566780.1	+	7	1152	c.786C>T	c.(784-786)tcC>tcT	p.S262S	WWOX_ENST00000402655.2_Intron|WWOX_ENST00000406884.2_Intron|WWOX_ENST00000408984.3_Silent_p.S262S|WWOX_ENST00000539474.2_Intron	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	262	Interaction with MAPT (By similarity).|Mediates targeting to the mitochondria (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		CCTCAGAGTCCCATCGGTGGG	0.463000													26	100					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43269343	43269343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43269343G>A	ENST00000372585.5	+	7	1069	c.974G>A	c.(973-975)gGg>gAg	p.G325E	SLC22A7_ENST00000487175.1_3'UTR|SLC22A7_ENST00000372589.3_Missense_Mutation_p.G323E|SLC22A7_ENST00000372574.3_Missense_Mutation_p.G323E	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	325						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GTGGCCGCCGGGGAACGGGTG	0.587000													19	36					0	0	1	0	0
TMEM71	137835	broad.mit.edu	37	8	133734298	133734298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133734298G>A	ENST00000356838.3	-	7	825	c.683C>T	c.(682-684)tCt>tTt	p.S228F	TMEM71_ENST00000523829.1_Missense_Mutation_p.S247F|TMEM71_ENST00000377901.4_Missense_Mutation_p.S184F	NM_144649.2	NP_653250.2	Q6P5X7	TMM71_HUMAN	transmembrane protein 71	247						integral to membrane		p.S228Y(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGCACATGCAGAAATGATTAA	0.348000													21	118					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30020409	30020409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30020409C>T	ENST00000350119.4	-	5	625	c.435G>A	c.(433-435)acG>acA	p.T145T	DOC2A_ENST00000564944.1_Silent_p.T145T|DOC2A_ENST00000564979.1_Silent_p.T145T	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	145	C2 1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						TCTGAGTCTTCGTTTTTAGCT	0.572000													9	44					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39382856	39382856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39382856G>A	ENST00000545653.1	-	9	1672	c.1142C>T	c.(1141-1143)cCt>cTt	p.P381L	DAB2_ENST00000509337.1_Missense_Mutation_p.P381L|DAB2_ENST00000339788.6_Intron|DAB2_ENST00000320816.6_Missense_Mutation_p.P402L	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	402					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			TCCTTTGGGAGGGCTTCCCAC	0.507000													30	89					0	0	1	0	0
PPP4C	5531	broad.mit.edu	37	16	30094997	30094997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30094997C>T	ENST00000279387.7	+	7	667	c.499C>T	c.(499-501)Ctc>Ttc	p.L167F	PPP4C_ENST00000561610.1_Missense_Mutation_p.L167F	NM_002720.1	NP_002711.1	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	167					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(2)|pancreas(1)|skin(1)|urinary_tract(1)	9						GCACGGGGGCCTCTCCCCCTC	0.632000													24	53					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22941460	22941460	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22941460T>C	ENST00000397104.3	-	5	977	c.978A>G	c.(976-978)gtA>gtG	p.V326V	ZNF99_ENST00000596209.1_Silent_p.V417V					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CAGTATGAATTACCTTATGTA	0.358000													19	63					0	0	1	0	0
BATF	10538	broad.mit.edu	37	14	76013010	76013010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76013010C>T	ENST00000286639.6	+	3	632	c.374C>T	c.(373-375)cCc>cTc	p.P125L	BATF_ENST00000555795.1_3'UTR|BATF_ENST00000555504.1_Intron	NM_006399.3	NP_006390.1	Q16520	BATF_HUMAN	basic leucine zipper transcription factor, ATF-like	125						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.028)		CGCTTCCAGCCCTGAGCTTCC	0.697000													5	13					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70087514	70087514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70087514G>A	ENST00000330891.5	-	4	647	c.421C>T	c.(421-423)Cgc>Tgc	p.R141C	BEST3_ENST00000476098.1_5'UTR|BEST3_ENST00000331471.4_Missense_Mutation_p.R141C|BEST3_ENST00000393365.1_Missense_Mutation_p.R35C|BEST3_ENST00000266661.4_Missense_Mutation_p.R35C|BEST3_ENST00000553096.1_Missense_Mutation_p.R35C|BEST3_ENST00000551160.1_Missense_Mutation_p.R35C|BEST3_ENST00000533674.1_5'UTR	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	141						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CTCACCGAGCGAAAGATGAGC	0.532000													31	68					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808114	48808114	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48808114C>T	ENST00000309835.3	+	1	352	c.342C>T	c.(340-342)ctC>ctT	p.L114L	STON1_ENST00000406226.1_Silent_p.L114L|STON1-GTF2A1L_ENST00000405008.1_Silent_p.L114L|STON1_ENST00000404752.1_Silent_p.L114L|STON1-GTF2A1L_ENST00000402114.2_Silent_p.L114L|STON1-GTF2A1L_ENST00000394751.3_Silent_p.L114L|STON1-GTF2A1L_ENST00000394754.1_Silent_p.L114L|STON1-GTF2A1L_ENST00000309827.2_Silent_p.L114L					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACAGCCCACTCGCAATATCAG	0.473000													39	68					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60737753	60737753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:60737753G>A	ENST00000400324.4	-	1	368	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S	DIAPH3_ENST00000400330.1_Missense_Mutation_p.P50S|DIAPH3_ENST00000400320.1_Missense_Mutation_p.P50S|DIAPH3_ENST00000377908.2_Missense_Mutation_p.P50S|DIAPH3_ENST00000267215.4_Missense_Mutation_p.P50S|DIAPH3_ENST00000400319.1_Missense_Mutation_p.P50S	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	50					actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GGCTCCTCGGGGCCACTGGGC	0.711000													18	52					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149494363	149494363	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149494363C>T	ENST00000378016.2	+	0	6834							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCCCCAGATTCCATTCCACAG	0.652000													13	67					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26241088	26241088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26241088C>T	ENST00000265944.5	+	3	215	c.49C>T	c.(49-51)Cct>Tct	p.P17S	MYO3A_ENST00000376301.1_Missense_Mutation_p.P17S|MYO3A_ENST00000543632.1_Missense_Mutation_p.P17S|MYO3A_ENST00000376302.1_Missense_Mutation_p.P17S	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	17					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CTTTCCTGATCCTTCTGATAC	0.333000													26	75					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	32483179	32483179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:32483179C>T	ENST00000359872.6	-	1	1134	c.373G>A	c.(373-375)Gac>Aac	p.D125N		NM_001094.4	NP_001085.2	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	125					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	AGATGGGGGTCCGGGATCTGC	0.597000													28	45					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754616	49754616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49754616G>A	ENST00000304801.3	-	1	437	c.285C>T	c.(283-285)ttC>ttT	p.F95F		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	95					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					AGTCCTTCAGGAACAGAACAT	0.527000													42	106					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14022123	14022123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:14022123C>T	ENST00000382080.1	-	5	1228	c.513G>A	c.(511-513)gaG>gaA	p.E171E	RP11-3G21.1_ENST00000527110.1_RNA|SGCZ_ENST00000421524.2_Silent_p.E124E	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	158					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CAATGGTAATCTCATCTTCAT	0.423000													12	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179441006	179441006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179441006C>T	ENST00000589042.1	-	326	70077	c.69853G>A	c.(69853-69855)Gag>Aag	p.E23285K	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E20717K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E21644K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E14412K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E14345K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E14220K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21644	Fibronectin type-III 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCCAGGCCTCGTCTCCTACT	0.443000													25	42					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160849133	160849133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160849133C>T	ENST00000326245.3	-	7	872	c.757G>A	c.(757-759)Gga>Aga	p.G253R	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	253	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACCCTCATTCCAGCACACAAG	0.502000													35	85					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012875	29012875	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29012875G>A	ENST00000377175.1	-	1	142	c.78C>T	c.(76-78)atC>atT	p.I26I		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						CTCCTGACAGGATCATCTCCA	0.403000													44	110					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46832585	46832585	+	Missense_Mutation	SNP	G	G	A	rs145401391		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46832585G>A	ENST00000339613.2	+	12	1649	c.1394G>A	c.(1393-1395)cGg>cAg	p.R465Q	AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000300862.3_Missense_Mutation_p.R519Q|HIF3A_ENST00000244303.6_Missense_Mutation_p.R452Q|HIF3A_ENST00000420102.2_Missense_Mutation_p.R470Q|HIF3A_ENST00000377670.4_Missense_Mutation_p.R521Q|HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000600383.1_Missense_Mutation_p.R452Q			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	521	NTAD.|ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GCTGTCCCCCGGCCCCGTGCT	0.672000													25	62					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108117950	108117950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108117950G>A	ENST00000273353.3	-	35	5017	c.4961C>T	c.(4960-4962)tCc>tTc	p.S1654F		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1654						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTGGCCCAGGGATTTGGTTGC	0.468000													25	61					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1775232	1775232	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1775232G>A	ENST00000236671.2	-	7	1096	c.964C>T	c.(964-966)Cag>Tag	p.Q322*	RP11-295K3.1_ENST00000427721.1_Silent_p.F192F	NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	322					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCTCGCCCTGAATCAGCGGC	0.692000													9	10					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169589405	169589405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169589405G>A	ENST00000261509.6	+	3	1184	c.973G>A	c.(973-975)Gac>Aac	p.D325N	PALLD_ENST00000333488.4_Missense_Mutation_p.D202N|PALLD_ENST00000512127.1_5'UTR|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Missense_Mutation_p.D325N	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	325	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TGAGGGAGGGGACCTCCATAC	0.517000									Pancreatic Cancer, Familial Clustering of				33	99					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58275715	58275715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58275715G>A	ENST00000300896.4	-	27	3534	c.3340C>T	c.(3340-3342)Cgg>Tgg	p.R1114W	USP32_ENST00000592339.1_Missense_Mutation_p.R784W	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1114					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TCTTTCTTCCGGGTATGCACA	0.478000													50	122					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228509413	228509413	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228509413G>A	ENST00000570156.2	+	66	17816	c.17742G>A	c.(17740-17742)ctG>ctA	p.L5914L	OBSCN_ENST00000366707.4_Silent_p.L2591L|OBSCN_ENST00000422127.1_Silent_p.L4957L|OBSCN_ENST00000284548.11_Silent_p.L4957L|OBSCN_ENST00000366709.4_Silent_p.L2076L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4957	PH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCTCTCTGCTGATCACTGGCC	0.612000													22	53					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196799399	196799399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196799399C>T	ENST00000312428.6	-	21	3487	c.3387G>A	c.(3385-3387)gaG>gaA	p.E1129E		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1129	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTGAAATAATCTCTATGAGTT	0.393000													68	159					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2418758	2418758	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2418758C>T	ENST00000449969.1	+	7	1137	c.976C>T	c.(976-978)Cag>Tag	p.Q326*	PLCH2_ENST00000288766.5_Intron|PLCH2_ENST00000378488.3_Nonsense_Mutation_p.Q353*|PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000419816.2_Nonsense_Mutation_p.Q353*|PLCH2_ENST00000378486.3_Nonsense_Mutation_p.Q353*			O75038	PLCH2_HUMAN	phospholipase C, eta 2	353	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GCTCATGTCCCAGTCACGGGT	0.627000													7	25					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148921668	148921668	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148921668C>T	ENST00000262085.3	+	8	2050	c.1945C>T	c.(1945-1947)Ctg>Ttg	p.L649L	ZNF282_ENST00000479907.1_3'UTR	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	649					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CAAGGACCACCTGCGCGTGCA	0.731000													9	31					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7675993	7675993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7675993C>T	ENST00000446248.2	+	11	1244	c.1143C>T	c.(1141-1143)ttC>ttT	p.F381F	CAMSAP3_ENST00000160298.4_Silent_p.F354F	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	354					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CTCCTGTCTTCACCTTCCGCC	0.652000													41	81					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	73043362	73043362	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73043362A>G	ENST00000264839.7	+	25	3737	c.3737A>G	c.(3736-3738)aAg>aGg	p.K1246R	RIMS1_ENST00000401910.3_Missense_Mutation_p.K717R|RIMS1_ENST00000538414.1_Missense_Mutation_p.K203R|RIMS1_ENST00000348717.5_Missense_Mutation_p.K1180R|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000517960.1_Missense_Mutation_p.K1180R|RIMS1_ENST00000521978.1_Missense_Mutation_p.K1397R|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000518273.1_Intron|RIMS1_ENST00000491071.2_Missense_Mutation_p.K1220R|RIMS1_ENST00000425662.2_Intron			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1397					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TCCATCATGAAGAGCACCAGT	0.448000													3	9					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23647609	23647609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23647609G>A	ENST00000261584.4	-	4	410	c.258C>T	c.(256-258)acC>acT	p.T86T		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	86	Interaction with BRCA1.|Interaction with RAD51.|Required for its oligomerization and is important for its focal concentration at DNA damage sites.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		CATCAAGATGGGTTTTGATGT	0.328000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					9	16					0	0	1	0	0
MSRB3	253827	broad.mit.edu	37	12	65857063	65857063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:65857063G>A	ENST00000308259.5	+	7	793	c.519G>A	c.(517-519)ggG>ggA	p.G173G	MSRB3_ENST00000355192.3_Silent_p.G180G|MSRB3_ENST00000535664.1_Silent_p.G173G	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	180					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		GAGGCAGTGGGGTCGCCAGCC	0.502000													14	44					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55522891	55522891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:55522891G>A	ENST00000436346.1	-	31	6234	c.5393C>T	c.(5392-5394)cCt>cTt	p.P1798L	CCDC88A_ENST00000422883.2_Missense_Mutation_p.P299L|CCDC88A_ENST00000263630.8_Missense_Mutation_p.P1770L|CCDC88A_ENST00000336838.6_Missense_Mutation_p.P1797L|CCDC88A_ENST00000413716.2_Intron	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1798					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						AGTTGCATAAGGGTTACTATC	0.413000													31	79					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64746713	64746713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:64746713G>A	ENST00000543942.2	-	2	1002	c.376C>T	c.(376-378)Cta>Tta	p.L126L	RPS11P6_ENST00000535684.1_RNA|C12orf56_ENST00000333722.5_Silent_p.L126L	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	126										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		AATGGAAATAGGAATTTCCTG	0.333000													5	49					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12164447	12164447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12164447G>A	ENST00000263932.2	+	4	502	c.280G>A	c.(280-282)Gag>Aag	p.E94K	TNFRSF8_ENST00000417814.2_5'UTR	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	94					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		CGACCTCGTGGAGAAGACGCC	0.592000													28	70					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41166002	41166002	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41166002C>T	ENST00000483722.1	-	2	406	c.221G>A	c.(220-222)gGg>gAg	p.G74E		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	74	Ig-like V-type.				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					GTAGCGGGGCCCTTTCACCCA	0.577000													48	128					0	0	1	0	0
DGUOK	1716	broad.mit.edu	37	2	74185845	74185845	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74185845C>T	ENST00000264093.4	+	7	901	c.816C>T	c.(814-816)acC>acT	p.T272T	DGUOK-AS1_ENST00000413452.1_RNA|DGUOK-AS1_ENST00000439192.1_RNA|DGUOK_ENST00000356837.6_Silent_p.T250T|DGUOK_ENST00000462685.1_3'UTR|DGUOK-AS1_ENST00000453103.1_RNA|DGUOK_ENST00000348222.1_Silent_p.T184T	NM_080916.2	NP_550438.1	Q16854	DGUOK_HUMAN	deoxyguanosine kinase	272					guanosine metabolic process|purine base metabolic process|purine deoxyribonucleoside metabolic process|purine-containing compound salvage	mitochondrial matrix	ATP binding|deoxyguanosine kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(1)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	8						AGGTAAACACCTTTGTAAAGA	0.413000													18	68					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114058095	114058095	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:114058095G>A	ENST00000462705.1	-	12	2585	c.1764C>T	c.(1762-1764)tcC>tcT	p.S588S	ZBTB20_ENST00000464560.1_Silent_p.S588S|ZBTB20_ENST00000481632.1_Silent_p.S588S|ZBTB20_ENST00000471418.1_Silent_p.S588S|ZBTB20_ENST00000474710.1_Silent_p.S661S|ZBTB20_ENST00000393785.2_Silent_p.S588S|ZBTB20_ENST00000357258.3_Silent_p.S588S	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		AGCACTCGTAGGACTTCTCTC	0.577000													19	201					0	0	1	0	0
SGCD	6444	broad.mit.edu	37	5	155771593	155771593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:155771593G>A	ENST00000435422.3	+	2	582	c.95G>A	c.(94-96)cGa>cAa	p.R32Q	SGCD_ENST00000337851.4_Missense_Mutation_p.R33Q|SGCD_ENST00000447401.1_Missense_Mutation_p.R33Q|SGCD_ENST00000517913.1_Missense_Mutation_p.R33Q	NM_001128209.1	NP_001121681.1	Q92629	SGCD_HUMAN	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	32					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|prostate(1)	24	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGCGGAAACGATGCCTGTAT	0.483000													9	81					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76382154	76382154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76382154C>T	ENST00000357063.3	+	11	3151	c.1891C>T	c.(1891-1893)Cct>Tct	p.P631S	LMO7_ENST00000377534.3_Missense_Mutation_p.P631S|LMO7_ENST00000321797.8_Missense_Mutation_p.P346S|LMO7_ENST00000526202.1_Intron|LMO7_ENST00000341547.4_Intron|LMO7_ENST00000465261.2_Missense_Mutation_p.P346S			Q8WWI1	LMO7_HUMAN	LIM domain 7	631						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AATATTAGTTCCTTCATATCG	0.448000													7	65					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63726506	63726506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:63726506C>T	ENST00000421025.1	+	5	764	c.495C>T	c.(493-495)ttC>ttT	p.F165F	ZNF679_ENST00000255746.4_Silent_p.F165F	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						TCAAAGTCTTCGGCAAATTTT	0.328000													8	22					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233515108	233515108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233515108G>A	ENST00000366624.3	+	9	2617	c.2356G>A	c.(2356-2358)Gag>Aag	p.E786K	MLK4_ENST00000366622.1_Missense_Mutation_p.E232K	NM_032435.2	NP_115811.2																					CACCTGTGGGGAGGCCAGCAG	0.597000													8	79					0	0	1	0	0
C2orf62	375307	broad.mit.edu	37	2	219232205	219232205	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219232205G>A	ENST00000289388.3	+	9	914	c.885G>A	c.(883-885)gaG>gaA	p.E295E	AC021016.6_ENST00000441749.1_RNA|C2orf62_ENST00000481940.1_3'UTR	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	295										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TATGGGAGGAGGATATGGAGC	0.567000													39	93					0	0	1	0	0
INHBE	83729	broad.mit.edu	37	12	57849343	57849343	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57849343C>T	ENST00000266646.2	+	1	240	c.24C>T	c.(22-24)ctC>ctT	p.L8L	INHBE_ENST00000551553.1_Intron	NM_031479.3	NP_113667.1	P58166	INHBE_HUMAN	inhibin, beta E	8					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						ATGTCCAGCTCTGGCTGGTGC	0.632000													7	37					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57762304	57762304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57762304G>A	ENST00000360716.3	+	17	2420	c.2199G>A	c.(2197-2199)gaG>gaA	p.E733E	CCDC135_ENST00000394337.4_Silent_p.E733E|CCDC135_ENST00000336825.8_Silent_p.E668E			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	733						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						CTTTACAGGAGCGCATGATGC	0.587000													54	124					0	0	1	0	0
SLC25A19	60386	broad.mit.edu	37	17	73282450	73282450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73282450G>A	ENST00000402418.3	-	2	1132	c.223C>T	c.(223-225)Ccg>Tcg	p.P75S	SLC25A19_ENST00000580994.1_Missense_Mutation_p.P75S|SLC25A19_ENST00000320362.3_Missense_Mutation_p.P75S|SLC25A19_ENST00000375261.4_Missense_Mutation_p.P75S|SLC25A19_ENST00000416858.2_Missense_Mutation_p.P75S|SLC25A19_ENST00000442286.2_Missense_Mutation_p.P75S			Q9HC21	TPC_HUMAN	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	75						integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			AAAGCTGTCGGACCCTCCTCC	0.577000													35	99					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102711298	102711298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102711298G>A	ENST00000299855.5	-	5	908	c.652C>T	c.(652-654)Cat>Tat	p.H218Y		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	218					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CCAATTTCATGAGCAGCAACG	0.423000													33	80					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754498	49754498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49754498G>A	ENST00000304801.3	-	1	555	c.403C>T	c.(403-405)Ccc>Tcc	p.P135S		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	135					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TTTCCAGAGGGATCTTGGCCC	0.507000													7	109					0	0	1	0	0
H2BFM	286436	broad.mit.edu	37	X	103294923	103294923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:103294923G>A	ENST00000243297.5	+	3	689	c.689G>A	c.(688-690)gGg>gAg	p.G230E	H2BFM_ENST00000355016.3_Missense_Mutation_p.G127E					H2B histone family, member M											endometrium(1)|lung(1)|ovary(1)	3						CTGCTGCCGGGGAAGATGGGC	0.647000													3	3					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17138385	17138385	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:17138385G>A	ENST00000285681.2	+	3	562	c.193G>A	c.(193-195)Gag>Aag	p.E65K	USP25_ENST00000400183.2_Missense_Mutation_p.E65K|USP25_ENST00000351097.5_Missense_Mutation_p.E65K|USP25_ENST00000285679.6_Missense_Mutation_p.E65K			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	65					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		CCCTCAGCAGGAGGAGACAAC	0.398000													7	92					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62407280	62407280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62407280C>T	ENST00000245663.4	-	3	1123	c.973G>A	c.(973-975)Gac>Aac	p.D325N	ZBTB46_ENST00000395104.1_Missense_Mutation_p.D325N|ZBTB46_ENST00000302995.2_Missense_Mutation_p.D325N	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CCTCGGCTGTCGGAGCTGCTG	0.637000													29	54					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88854251	88854251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88854251G>A	ENST00000537554.1	-	2	4305	c.743C>T	c.(742-744)gCc>gTc	p.A248V	CNR1_ENST00000549890.1_Missense_Mutation_p.A248V|CNR1_ENST00000535130.1_Missense_Mutation_p.A248V|CNR1_ENST00000369499.2_Missense_Mutation_p.A248V|CNR1_ENST00000369501.2_Missense_Mutation_p.A248V|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000428600.2_Missense_Mutation_p.A248V|CNR1_ENST00000549716.1_Missense_Mutation_p.A187V|CNR1_ENST00000468898.1_Missense_Mutation_p.A215V	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	248					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	AGGCAGCACGGCGATCACAAT	0.527000													9	65					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128463994	128463994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128463994C>T	ENST00000322313.4	-	22	4072	c.3914G>A	c.(3913-3915)cGa>cAa	p.R1305Q		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1305					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CCGGCCCCCTCGAGAAGGGGT	0.617000													32	204					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9402046	9402046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9402046C>T	ENST00000378501.2	+	23	2236	c.2221C>T	c.(2221-2223)Cgc>Tgc	p.R741C	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.R753C|PLCB4_ENST00000278655.4_Missense_Mutation_p.R741C|PLCB4_ENST00000378493.1_Missense_Mutation_p.R741C|PLCB4_ENST00000334005.3_Missense_Mutation_p.R741C|PLCB4_ENST00000378473.3_Missense_Mutation_p.R753C	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	741	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						ATTCCGAACTCGCATGGTTAT	0.388000													28	72					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23731413	23731413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23731413G>A	ENST00000304749.2	-	1	161	c.91C>T	c.(91-93)Ccg>Tcg	p.P31S	CST1_ENST00000398402.1_Missense_Mutation_p.P31S	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	31			P -> L (in dbSNP:rs2070856).			extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					ATGCCACCCGGGATTATCCTA	0.562000													5	51					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150696415	150696415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150696415G>A	ENST00000297494.3	+	9	1451	c.1094G>A	c.(1093-1095)aGg>aAg	p.R365K	NOS3_ENST00000467517.1_Missense_Mutation_p.R365K|NOS3_ENST00000484524.1_Missense_Mutation_p.R365K|NOS3_ENST00000461406.1_Missense_Mutation_p.R159K	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	365	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	ATCGGCACGAGGAACCTGTGT	0.627000													41	158					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52826857	52826857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52826857C>T	ENST00000252245.5	-	2	898	c.678G>A	c.(676-678)agG>agA	p.R226R		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	226	Coil 1B.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		CCTGCATGTTCCTCAGTTCAG	0.537000													34	77					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67223077	67223077	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67223077T>C	ENST00000314586.6	-	3	293	c.53A>G	c.(52-54)gAg>gGg	p.E18G	EXOC3L1_ENST00000562887.1_5'UTR	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	18	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						CTCTGGCCACTCAGGTCCTGG	0.597000													8	8					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89658656	89658656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89658656C>T	ENST00000355754.6	-	5	698	c.601G>A	c.(601-603)Gag>Aag	p.E201K		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	201						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		AACTTTAGCTCCAGGGTAAAA	0.493000													32	94					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125591686	125591686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125591686C>T	ENST00000316519.6	+	8	993	c.787C>T	c.(787-789)Ctt>Ttt	p.L263F	AACS_ENST00000261686.6_Missense_Mutation_p.L263F|AACS_ENST00000316543.10_5'UTR	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	263					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		GGATGACTTTCTTGCCACCGG	0.607000													25	60					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69000035	69000035	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:69000035G>T	ENST00000288368.4	+	19	2381	c.2104G>T	c.(2104-2106)Gta>Tta	p.V702L	RP11-403D15.2_ENST00000526901.1_RNA|PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	702	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TGTGCATGCTGTAGGAAGAGG	0.453000													37	142					1.47244e-24	1.48199e-24	1	1	0
NAALADL2	254827	broad.mit.edu	37	3	175041968	175041968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:175041968C>T	ENST00000454872.1	+	5	1072	c.944C>T	c.(943-945)tCc>tTc	p.S315F	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	315					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TTTTAGCTTTCCTCATTGGAA	0.378000													43	262					0	0	1	0	0
S100A12	6283	broad.mit.edu	37	1	153347053	153347053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153347053C>T	ENST00000368737.3	-	2	133	c.16G>A	c.(16-18)Gag>Aag	p.E6K		NM_005621.1	NP_005612.1	P80511	S10AC_HUMAN	S100 calcium binding protein A12	6					defense response to bacterium|defense response to fungus|inflammatory response|innate immune response|killing of cells of other organism|positive regulation of I-kappaB kinase/NF-kappaB cascade|xenobiotic metabolic process	cytosol|extracellular region|insoluble fraction|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			endometrium(1)|kidney(1)|skin(2)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	TCCAGATGCTCTTCAAGTTTT	0.483000													48	110					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75857507	75857507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:75857507C>T	ENST00000322507.8	-	23	4610	c.4301G>A	c.(4300-4302)cGa>cAa	p.R1434Q	COL12A1_ENST00000483888.2_Missense_Mutation_p.R1434Q|COL12A1_ENST00000416123.2_Missense_Mutation_p.R1434Q|COL12A1_ENST00000345356.6_Missense_Mutation_p.R270Q	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1434	Fibronectin type-III 9.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AGTTTCCATTCGACTCACATA	0.368000													19	132					0	0	1	0	0
CLSPN	63967	broad.mit.edu	37	1	36226473	36226473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36226473G>A	ENST00000251195.5	-	8	1145	c.1049C>T	c.(1048-1050)aCt>aTt	p.T350I	CLSPN_ENST00000318121.3_Missense_Mutation_p.T350I|CLSPN_ENST00000520551.1_Missense_Mutation_p.T350I|CLSPN_ENST00000373220.3_Missense_Mutation_p.T350I			Q9HAW4	CLSPN_HUMAN	claspin	350					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGTATTTGCAGTGTCTATGAT	0.373000													18	63					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	53986319	53986319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53986319C>T	ENST00000312233.2	-	6	1755	c.1189G>A	c.(1189-1191)Gag>Aag	p.E397K		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	397					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GGGAGCAGCTCCTGGCCCAGG	0.677000													6	21					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24563606	24563606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24563606G>A	ENST00000535378.1	-	17	3187	c.2545C>T	c.(2545-2547)Cgg>Tgg	p.R849W	KIAA0319_ENST00000543707.1_Missense_Mutation_p.R858W|KIAA0319_ENST00000430948.2_Missense_Mutation_p.R813W|KIAA0319_ENST00000378214.3_Missense_Mutation_p.R858W|KIAA0319_ENST00000537886.1_Missense_Mutation_p.R858W	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	858					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GAGTGGGCCCGAATCTTCTGG	0.567000													18	39					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127239494	127239494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127239494C>T	ENST00000265825.5	+	5	1399	c.1180C>T	c.(1180-1182)Cgt>Tgt	p.R394C	FSCN3_ENST00000420086.2_Missense_Mutation_p.R260C	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	394						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						ATTGCGAGGTCGTTATGGCTA	0.507000													43	72					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128677123	128677123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128677123G>A	ENST00000344954.6	+	7	1059	c.671G>A	c.(670-672)cGg>cAg	p.R224Q	FLI1_ENST00000429175.2_Missense_Mutation_p.R257Q|FLI1_ENST00000525560.1_Missense_Mutation_p.R64Q|FLI1_ENST00000281428.8_Missense_Mutation_p.R191Q|FLI1_ENST00000534087.1_Missense_Mutation_p.R224Q			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	257					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		ACAGAGCAACGGCCCCAGCCA	0.512000			T	EWSR1	Ewing sarcoma								7	19					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136596793	136596793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136596793G>A	ENST00000531224.1	-	6	1981	c.1729C>T	c.(1729-1731)Cat>Tat	p.H577Y	BCLAF1_ENST00000527536.1_Missense_Mutation_p.H577Y|BCLAF1_ENST00000527759.1_Missense_Mutation_p.H575Y|BCLAF1_ENST00000392348.2_Missense_Mutation_p.H575Y|BCLAF1_ENST00000530767.1_Missense_Mutation_p.H404Y|BCLAF1_ENST00000353331.4_Missense_Mutation_p.H575Y	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	577					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTGACAGAATGGACAAGTGTA	0.398000													17	189					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657830	72657830	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72657830G>A	ENST00000425256.1	-	0	2081					NR_002164.1																						gacgatttgggagtgtccttg	0.507000													70	189					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65016033	65016033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:65016033C>T	ENST00000394156.3	-	8	1624	c.1171G>A	c.(1171-1173)Gaa>Aaa	p.E391K	CDH11_ENST00000268603.4_Missense_Mutation_p.E391K|CDH11_ENST00000566827.1_Missense_Mutation_p.E265K			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	391	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TCTTGGACTTCGTGGATGTAA	0.502000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			17	105					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11725817	11725817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11725817C>T	ENST00000262442.3	+	47	8981	c.8913C>T	c.(8911-8913)gcC>gcT	p.A2971A	DNAH9_ENST00000454412.2_Silent_p.A2971A	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2971	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGTTCCCAGCCATTGTGAACT	0.552000													48	67					0	0	1	0	0
ADGRG6	57211	broad.mit.edu	37	6	142691444	142691444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:142691444G>A	ENST00000230173.6	+	4	1059	c.583G>A	c.(583-585)Gaa>Aaa	p.E195K	GPR126_ENST00000367609.3_Missense_Mutation_p.E195K|GPR126_ENST00000545477.1_Intron|GPR126_ENST00000296932.8_Missense_Mutation_p.E195K|GPR126_ENST00000367608.2_Missense_Mutation_p.E195K	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	195	Pentaxin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		AGTTGGCCATGAAGACAGTGA	0.438000													14	24					0	0	1	0	0
CSRP3	8048	broad.mit.edu	37	11	19207763	19207763	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:19207763C>T	ENST00000533783.1	-	5	654	c.414_splice	c.e5+1	p.K138_splice	CSRP3_ENST00000265968.3_Splice_Site_p.K138_splice	NM_003476.4	NP_003467.1	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3 (cardiac LIM protein)	138	LIM zinc-binding 2.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10						AAGGTCTTACCTTGCCACCTC	0.498000													21	83					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063593	9063593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9063593C>T	ENST00000397910.4	-	3	24056	c.23853G>A	c.(23851-23853)agG>agA	p.R7951R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7953	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGGACCCCTCCTCATAAGAG	0.463000													7	63					0	0	1	0	0
FBXL16	146330	broad.mit.edu	37	16	747111	747111	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:747111C>T	ENST00000397621.1	-	2	626	c.295G>A	c.(295-297)Gag>Aag	p.E99K	FBXL16_ENST00000324361.5_Missense_Mutation_p.E99K	NM_153350.3	NP_699181.2	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	99	F-box.									endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)	10		Hepatocellular(780;0.0218)				AGGATCTTCTCGTCCGTGGCC	0.697000													7	39					0	0	1	0	0
OR52N5	390075	broad.mit.edu	37	11	5799018	5799018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5799018G>A	ENST00000317093.2	-	1	879	c.847C>T	c.(847-849)Cac>Tac	p.H283Y	TRIM5_ENST00000380027.1_Intron	NM_001001922.2	NP_001001922.2	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N, member 5	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(1)|lung(17)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ACAATGATGTGAAGAGAAGGG	0.423000													24	14					0	0	1	0	0
PUS7	54517	broad.mit.edu	37	7	105105785	105105785	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:105105785G>A	ENST00000356362.2	-	13	1816	c.1602C>T	c.(1600-1602)ttC>ttT	p.F534F	PUS7_ENST00000469408.1_Silent_p.F534F	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	534	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding	p.F534F(2)		breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						AGATAACATCGAAACCAGGCA	0.343000													17	46					0	0	1	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474748	20474748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20474748C>T	ENST00000375102.3	+	5	592	c.490C>T	c.(490-492)Ctc>Ttc	p.L164F		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	121					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GGTTCTGTGCCTCATGAACCA	0.557000													14	116					0	0	1	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90673158	90673158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90673158C>T	ENST00000371927.3	+	6	1679	c.721C>T	c.(721-723)Cac>Tac	p.H241Y	STAMBPL1_ENST00000371926.3_Missense_Mutation_p.H241Y|STAMBPL1_ENST00000371924.1_Missense_Mutation_p.H241Y|STAMBPL1_ENST00000371922.1_Missense_Mutation_p.H75Y			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	241							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TTATGCTAGCCACTCTCCTCC	0.463000													46	89					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50895042	50895042	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50895042G>A	ENST00000380817.2	-	30	4148	c.3965C>T	c.(3964-3966)tCc>tTc	p.S1322F	SBF1_ENST00000476293.1_5'UTR|SBF1_ENST00000390679.3_Missense_Mutation_p.S1296F|SBF1_ENST00000348911.6_Missense_Mutation_p.S1297F	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	1296	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		AGCTAGCCGGGAGCCCACATC	0.677000													6	16					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175048543	175048543	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175048543G>A	ENST00000239462.4	+	3	597	c.484G>A	c.(484-486)Gag>Aag	p.E162K		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	162					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGAGGGCAGGGAGGGCCCCGC	0.711000													15	7					0	0	1	0	0
FAM73A	374986	broad.mit.edu	37	1	78269072	78269072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:78269072C>T	ENST00000370791.3	+	4	523	c.491C>T	c.(490-492)tCt>tTt	p.S164F	FAM73A_ENST00000443751.2_Missense_Mutation_p.S126F	NM_001270384.1|NM_198549.3	NP_001257313.1|NP_940951.1	Q8NAN2	FA73A_HUMAN	family with sequence similarity 73, member A	164						integral to membrane				breast(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	19				Colorectal(170;0.226)		TATTCAGGTTCTGCACAGAGT	0.299000													16	48					0	0	1	0	0
DRG1	4733	broad.mit.edu	37	22	31807018	31807018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31807018C>T	ENST00000331457.4	+	4	524	c.363C>T	c.(361-363)atC>atT	p.I121I	DRG1_ENST00000433341.1_3'UTR	NM_004147.3	NP_004138.1	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	121	G.				multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(1)	11						TCCCAGGTATCATTGAAGGTG	0.413000													23	58					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103120032	103120032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103120032C>T	ENST00000295269.4	+	3	1303	c.846C>T	c.(844-846)atC>atT	p.I282I		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	282					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TGTTTGGCATCGTTTTTGGAT	0.398000													21	51					0	0	1	0	0
LPPR3	79948	broad.mit.edu	37	19	815761	815761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:815761C>T	ENST00000359894.2	-	3	229	c.166G>A	c.(166-168)Gac>Aac	p.D56N	LPPR3_ENST00000520876.3_Missense_Mutation_p.D56N	NM_024888.2	NP_079164.1	Q6T4P5	LPPR3_HUMAN		56						integral to membrane	phosphatidate phosphatase activity										AGAGTGCGGTCATAGCACTGG	0.617000													7	31					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73731423	73731423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:73731423G>A	ENST00000427855.1	+	22	3216	c.3114G>A	c.(3112-3114)caG>caA	p.Q1038Q	PAPLN_ENST00000340738.5_Silent_p.Q1011Q|PAPLN_ENST00000381166.3_Silent_p.Q1038Q|PAPLN_ENST00000554301.1_Silent_p.Q1038Q|PAPLN_ENST00000555445.1_Silent_p.Q1022Q			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	1038	Ig-like C2-type 2.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CACACCCACAGCCTGCAAACA	0.657000													49	113					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29867071	29867071	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29867071G>A	ENST00000399218.4	-	4	1544	c.1489C>T	c.(1489-1491)Cct>Tct	p.P497S	GAREM_ENST00000269209.6_Missense_Mutation_p.P497S	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		AGAGTCCCAGGGATGGGAAGA	0.507000													43	89					0	0	1	0	0
PHYHIPL	84457	broad.mit.edu	37	10	60994167	60994167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:60994167G>A	ENST00000373880.4	+	2	474	c.210G>A	c.(208-210)tgG>tgA	p.W70*	PHYHIPL_ENST00000373878.3_Nonsense_Mutation_p.W44*	NM_032439.3	NP_115815.2	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein-like	70	Fibronectin type-III.									NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(3)|skin(1)|urinary_tract(1)	18						AGATTTCATGGGAAATGGATT	0.338000													17	86					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2350132	2350132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2350132C>T	ENST00000301732.5	-	13	2185	c.1485G>A	c.(1483-1485)ggG>ggA	p.G495G	ABCA3_ENST00000382381.3_Silent_p.G437G	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	495					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				CCCTTGGCTTCCCACACCAAT	0.547000													42	83					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204923962	204923962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204923962C>T	ENST00000367172.4	+	7	746	c.418C>T	c.(418-420)Cct>Tct	p.P140S	NFASC_ENST00000513543.1_Missense_Mutation_p.P134S|NFASC_ENST00000338586.6_Missense_Mutation_p.P140S|NFASC_ENST00000367169.4_Missense_Mutation_p.P140S|NFASC_ENST00000360049.4_Missense_Mutation_p.P134S|NFASC_ENST00000367171.4_Missense_Mutation_p.P140S|NFASC_ENST00000401399.1_Missense_Mutation_p.P140S|NFASC_ENST00000539706.1_Missense_Mutation_p.P134S|NFASC_ENST00000403080.1_Missense_Mutation_p.P140S|NFASC_ENST00000367170.4_Missense_Mutation_p.P140S|NFASC_ENST00000339876.6_Missense_Mutation_p.P140S|NFASC_ENST00000404907.1_Missense_Mutation_p.P134S|NFASC_ENST00000404076.1_Missense_Mutation_p.P134S|NFASC_ENST00000338515.6_Missense_Mutation_p.P140S			O94856	NFASC_HUMAN	neurofascin	140					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCCAGAATCTCCTCTGTGGCC	0.592000													46	136					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583945	88583945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88583945G>A	ENST00000339673.6	+	6	1114	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.E323K|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	339					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		TCCCAGCAGTGAGTCCAGCCA	0.552000													13	95					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36780080	36780080	+	Missense_Mutation	SNP	C	C	T	rs56070233	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36780080C>T	ENST00000416516.2	-	2	561	c.71G>A	c.(70-72)cGg>cAg	p.R24Q		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	24			R -> Q (in dbSNP:rs56070233).			cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TGTCAGGGCCCGGGCTTTGTT	0.567000													48	132					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215440421	215440421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215440421G>A	ENST00000427124.1	+	3	1218	c.416G>A	c.(415-417)cGa>cAa	p.R139Q	AC107218.3_ENST00000437883.1_RNA|AC107218.3_ENST00000412896.1_RNA|VWC2L_ENST00000312504.5_Silent_p.T182T			B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	0	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						CAGGAACGACGATAATTCCAG	0.463000													33	146					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104044282	104044282	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104044282T>C	ENST00000388887.2	+	11	1387	c.1183T>C	c.(1183-1185)Tat>Cat	p.Y395H		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	395	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGACAAAGCTTATGCCTGGCC	0.458000													14	44					0	0	1	0	0
FAM110B	90362	broad.mit.edu	37	8	59059522	59059522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:59059522G>A	ENST00000361488.3	+	5	1613	c.733G>A	c.(733-735)Gaa>Aaa	p.E245K	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	245						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CGACCCTGTGGAACCAGCTTG	0.607000													32	108					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23782434	23782434	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23782434G>A	ENST00000336689.3	-	3	332	c.288C>T	c.(286-288)tcC>tcT	p.S96S	ASAP3_ENST00000437606.2_Silent_p.S96S	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	96					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						GGAAGCCTGTGGACAGCTCAT	0.567000													40	90					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45807055	45807055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45807055C>T	ENST00000358525.4	-	8	1392	c.1277G>A	c.(1276-1278)aGc>aAc	p.S426N	SLC6A20_ENST00000353278.4_Missense_Mutation_p.S389N|SLC6A20_ENST00000493980.1_5'UTR|SLC6A20_ENST00000456124.2_Missense_Mutation_p.S426N	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	426					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		GGGCAGGTGGCTGGAGATGAT	0.632000													9	17					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61873986	61873986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61873986G>A	ENST00000280772.1	-	26	3136	c.2945C>T	c.(2944-2946)tCt>tTt	p.S982F	ANK3_ENST00000355288.2_Missense_Mutation_p.S116F|ANK3_ENST00000503366.1_Missense_Mutation_p.S983F|ANK3_ENST00000373827.2_Missense_Mutation_p.S976F	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	982	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TACTTACCCAGAATGAATGGG	0.348000													18	48					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47358979	47358979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47358979G>A	ENST00000545968.1	-	25	2619	c.2565C>T	c.(2563-2565)tcC>tcT	p.S855S	MYBPC3_ENST00000256993.4_Silent_p.S854S|MYBPC3_ENST00000399249.2_Silent_p.S855S	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	854	Fibronectin type-III 1.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		GGCTGGGCCTGGACATGCCGA	0.622000													20	33					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197189858	197189858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197189858C>T	ENST00000260983.2	-	6	769	c.587G>A	c.(586-588)gGg>gAg	p.G196E	HECW2_ENST00000409111.1_Intron	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	196	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TTTCTTTAGCCCAACTGCCCT	0.498000													41	91					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104709366	104709366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:104709366G>A	ENST00000406091.3	+	2	229	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K		NM_001100117.2	NP_001093587.1	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	108	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAAGATGGGAGAAGAATCACA	0.403000										HNSCC(12;0.0054)			21	58					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394087	233394087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233394087C>T	ENST00000258229.8	-	5	1755	c.1521G>A	c.(1519-1521)ggG>ggA	p.G507G	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	507						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GGCCTTCCTTCCCCACCTTAG	0.547000													18	49					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5363912	5363912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5363912G>A	ENST00000300773.2	-	1	897	c.843C>T	c.(841-843)ttC>ttT	p.F281F	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTAGTGGAGGGAACAGAAAAT	0.378000													29	65					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145427421	145427421	+	Silent	SNP	G	G	A	rs75157444	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145427421G>A	ENST00000511217.1	+	5	1198	c.1146G>A	c.(1144-1146)gcG>gcA	p.A382A	SH3RF2_ENST00000359120.4_Silent_p.A382A			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	382	SH3 3.						ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCTCTCAGCGAACATGTGAG	0.527000													41	29					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58722323	58722323	+	Silent	SNP	G	G	A	rs7478799		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58722323G>A	ENST00000300079.5	+	5	410	c.360G>A	c.(358-360)ttG>ttA	p.L120L	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Silent_p.L89L	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	89						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	AAGAAGTTTTGAAAAATTGTG	0.383000													25	50					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28116381	28116381	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28116381G>A	ENST00000354638.3	-	21	2318	c.2163C>T	c.(2161-2163)ctC>ctT	p.L721L	OCA2_ENST00000353809.5_Silent_p.L697L	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	721					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TGGCGGCTATGAGGCGCTGCT	0.577000									Oculocutaneous Albinism				19	51					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1993972	1993972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1993972C>T	ENST00000382722.5	-	11	1596	c.1234G>A	c.(1234-1236)Gag>Aag	p.E412K	CACNA2D4_ENST00000585708.1_Missense_Mutation_p.E348K|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.E412K|CACNA2D4_ENST00000586184.1_Missense_Mutation_p.E412K|CACNA2D4_ENST00000585732.1_Missense_Mutation_p.E328K|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.E348K	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	412	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AACACCGGCTCGTAGTCCTCC	0.567000													8	21					0	0	1	0	0
TAS2R14	50840	broad.mit.edu	37	12	11091013	11091013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11091013G>A	ENST00000537503.1	-	1	849	c.794C>T	c.(793-795)tCc>tTc	p.S265F	TAS2R14_ENST00000381852.4_5'UTR|PRR4_ENST00000536668.1_Intron	NM_023922.1	NP_076411.1	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	265					detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	8						CATCACCTGGGAAAGAATAAT	0.423000													11	120					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101818645	101818645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101818645G>A	ENST00000375001.3	+	35	3719	c.3296G>A	c.(3295-3297)gGg>gAg	p.G1099E		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1099	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GGGCCACCGGGGCCCCCGGGG	0.622000													19	59					0	0	1	0	0
POLD2	5425	broad.mit.edu	37	7	44156455	44156455	+	Silent	SNP	G	G	A	rs142289447	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44156455G>A	ENST00000406581.2	-	7	1390	c.741C>T	c.(739-741)ctC>ctT	p.L247L	POLD2_ENST00000452185.1_Silent_p.L247L|POLD2_ENST00000223361.3_Silent_p.L247L	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	247					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						TGTGGCTGAGGAGGTTGCCAG	0.637000													18	48					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76829014	76829014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76829014C>T	ENST00000248598.5	-	1	129	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	CCDC146_ENST00000285871.4_Intron|CCDC146_ENST00000431197.1_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	33					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						TTTGCTCTTTCATCTTTAATT	0.488000													20	109					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3834887	3834887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3834887G>A	ENST00000262961.4	-	2	158	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S	ZFR2_ENST00000591965.1_5'UTR	NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	50						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		GCAGCTGGGGGAAAGGCCGGG	0.697000													8	14					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32355867	32355867	+	Missense_Mutation	SNP	C	C	T	rs144275111		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32355867C>T	ENST00000298386.2	+	10	916	c.845C>T	c.(844-846)tCg>tTg	p.S282L	RXFP2_ENST00000380314.1_Missense_Mutation_p.S282L	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	282						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TCGTGCGATTCGCTCACAGTG	0.323000													7	63					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164507045	164507045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164507045G>A	ENST00000503008.1	-	6	1255	c.279C>T	c.(277-279)ctC>ctT	p.L93L	MARCH1_ENST00000274056.7_Silent_p.L93L|MARCH1_ENST00000514618.1_Silent_p.L349L|MARCH1_ENST00000339875.5_Silent_p.L76L	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	93					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AGGGTGTGATGAGGGGGCTCT	0.537000													16	44					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64111715	64111715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64111715G>A	ENST00000356786.5	+	14	1746	c.1702G>A	c.(1702-1704)Gac>Aac	p.D568N	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000301897.4_5'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	568					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGCTGCCATGGACCCCCAGGC	0.632000													41	67					0	0	1	0	0
TRAT1	50852	broad.mit.edu	37	3	108549612	108549612	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108549612G>A	ENST00000295756.6	+	2	333	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	TRAT1_ENST00000493604.1_3'UTR|TRAT1_ENST00000426646.1_Intron	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	35					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity	p.E35K(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						CCACTATGTGGAAAAGCAACG	0.428000													46	86					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813468	106813468	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106813468C>T	ENST00000407775.2	+	8	1408	c.1158C>T	c.(1156-1158)gtC>gtT	p.V386V	ZFPM2_ENST00000520492.1_Silent_p.V254V|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Silent_p.V117V|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Silent_p.V254V|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	386					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AGCTCCATGTCCCTAGCGGCA	0.512000													60	99					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117728230	117728230	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117728230G>A	ENST00000317775.6	-	4	1539	c.852_splice	c.e4-1	p.P285_splice	NOS1_ENST00000344089.3_Splice_Site_p.P304_splice|NOS1_ENST00000338101.4_Splice_Site_p.P285_splice	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	285					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGAGGTGGGGGGCTGCAGGAG	0.552000													14	36					0	0	1	0	0
FAM89A	375061	broad.mit.edu	37	1	231155655	231155655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:231155655G>A	ENST00000366654.4	-	2	543	c.509C>T	c.(508-510)cCt>cTt	p.P170L	MIR1182_ENST00000408363.1_RNA|FAM89A_ENST00000494111.1_5'UTR	NM_198552.2	NP_940954.1	Q96GI7	FA89A_HUMAN	family with sequence similarity 89, member A	170										endometrium(1)|upper_aerodigestive_tract(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GGAGGAGACAGGCAGTGACAA	0.577000													6	64					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561402	44561402	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44561402G>A	ENST00000332567.4	-	1	586	c.234C>T	c.(232-234)ctC>ctT	p.L78L	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	78	TFIIS N-terminal.				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTCGGTCCACGAGCACCAGCT	0.642000													18	45					0	0	1	0	0
LDLRAP1	26119	broad.mit.edu	37	1	25891695	25891695	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:25891695C>T	ENST00000374338.4	+	8	898	c.779C>T	c.(778-780)tCg>tTg	p.S260L	LDLRAP1_ENST00000488127.1_3'UTR	NM_015627.2	NP_056442.2	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein 1	260	AP-2 complex binding.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGCGTTTTCGAGGTAATGC	0.562000													55	127					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46801018	46801018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46801018G>A	ENST00000230588.4	+	11	1361	c.1352G>A	c.(1351-1353)gGg>gAg	p.G451E		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	451	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			ACCAGCAAAGGGGACAAGCTT	0.483000													29	80					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117352753	117352753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117352753G>A	ENST00000321322.6	-	12	2665	c.2664C>T	c.(2662-2664)gtC>gtT	p.V888V	DSCAML1_ENST00000527706.1_Silent_p.V618V	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	828	Fibronectin type-III 1.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CAGGGTCGATGACTGTGTCCC	0.627000													24	63					0	0	1	0	0
SLC2A8	29988	broad.mit.edu	37	9	130167124	130167124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130167124C>T	ENST00000373371.3	+	8	1093	c.1004C>T	c.(1003-1005)gCc>gTc	p.A335V	SLC2A8_ENST00000373360.3_Missense_Mutation_p.A335V|SLC2A8_ENST00000373352.1_Missense_Mutation_p.A72V|SLC2A8_ENST00000485806.1_3'UTR	NM_001271712.1|NM_014580.3	NP_001258641.1|NP_055395.2	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 8	335						cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	11						AGCACGAGTGCCTTCGGCGCC	0.687000													9	42					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28534587	28534587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:28534587C>T	ENST00000357727.2	+	3	529	c.139C>T	c.(139-141)Cct>Tct	p.P47S	CREB5_ENST00000396300.2_Missense_Mutation_p.P40S|CREB5_ENST00000396299.2_Missense_Mutation_p.P14S|CREB5_ENST00000409603.1_Missense_Mutation_p.P14S	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	47					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						TTTGAAGTTTCCTTCAATAAA	0.408000													38	111					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092491	151092491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151092491C>T	ENST00000370340.3	+	3	622	c.355C>T	c.(355-357)Cat>Tat	p.H119Y	MAGEA4_ENST00000393920.1_Missense_Mutation_p.H119Y|MAGEA4_ENST00000393921.1_Missense_Mutation_p.H119Y|MAGEA4_ENST00000370337.4_Missense_Mutation_p.H119Y|MAGEA4_ENST00000276344.2_Missense_Mutation_p.H119Y|MAGEA4_ENST00000360243.2_Missense_Mutation_p.H119Y|MAGEA4_ENST00000370335.1_Missense_Mutation_p.H119Y			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	119	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGTTGGCTCATTTTCTGCT	0.517000													39	36					0	0	1	0	0
CIR1	9541	broad.mit.edu	37	2	175213483	175213483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:175213483G>A	ENST00000342016.3	-	10	1187	c.1095C>T	c.(1093-1095)agC>agT	p.S365S	CIR1_ENST00000362053.5_3'UTR	NM_004882.3	NP_004873.3	Q86X95	CIR1_HUMAN	corepressor interacting with RBPJ, 1	365	Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						TCTTCTCTGGGCTATGTTTAT	0.512000													46	127					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32932943	32932943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:32932943C>T	ENST00000383763.4	+	4	2310	c.2247C>T	c.(2245-2247)tcC>tcT	p.S749S		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	749					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACTTTGACTCCCCACGGGGTG	0.577000													8	54					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39883840	39883840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39883840G>A	ENST00000373186.4	-	3	692	c.555C>T	c.(553-555)gcC>gcT	p.A185A	MOCS1_ENST00000373188.2_Silent_p.A185A|MOCS1_ENST00000308559.7_Silent_p.A185A|MOCS1_ENST00000432280.2_Silent_p.A156A|MOCS1_ENST00000373195.3_Silent_p.A98A|MOCS1_ENST00000340692.5_Silent_p.A185A|MOCS1_ENST00000373175.4_Silent_p.A156A|MOCS1_ENST00000425303.2_Silent_p.A185A	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	185	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACTCAAACTTGGCAGGCACCA	0.597000													4	15					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167182137	167182137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167182137G>A	ENST00000519204.1	+	1	197	c.79G>A	c.(79-81)Ggc>Agc	p.G27S	TENM2_ENST00000545108.1_Intron|TENM2_ENST00000520393.1_Intron|TENM2_ENST00000518659.1_Intron|TENM2_ENST00000520394.1_Missense_Mutation_p.G27S					teneurin transmembrane protein 2																		ATGGAGACCCGGCAGTACCTC	0.527000													76	206					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933284	44933284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44933284C>T	ENST00000291187.4	-	6	1976	c.1654G>A	c.(1654-1656)Gac>Aac	p.D552N	ZNF229_ENST00000588931.1_Missense_Mutation_p.D558N|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				ATGTGGAGGTCGGAGCTCCGG	0.542000													33	80					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36933246	36933246	+	Missense_Mutation	SNP	G	G	A	rs144754091		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36933246G>A	ENST00000373103.1	-	15	2418	c.1871C>T	c.(1870-1872)tCg>tTg	p.S624L	CSF3R_ENST00000338937.5_Intron|CSF3R_ENST00000373106.1_Missense_Mutation_p.S624L|CSF3R_ENST00000361632.4_Missense_Mutation_p.S624L|CSF3R_ENST00000373104.1_Missense_Mutation_p.S624L|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000440588.2_Missense_Mutation_p.S624L|CSF3R_ENST00000418048.2_Missense_Mutation_p.S624L|CSF3R_ENST00000331941.5_Missense_Mutation_p.S624L	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	624					cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GTGTAGCTCCGACCCCTCTGC	0.602000													9	35					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160100247	160100247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160100247C>T	ENST00000361216.3	+	13	1776	c.1687C>T	c.(1687-1689)Cct>Tct	p.P563S	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Missense_Mutation_p.P563S	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	563					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGGAAAGTTTCCTCGGGGCTT	0.552000													9	82					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50596572	50596572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50596572C>T	ENST00000262794.5	+	23	3236	c.3153C>T	c.(3151-3153)gcC>gcT	p.A1051A	MOV10L1_ENST00000545383.1_Silent_p.A1051A|MOV10L1_ENST00000540615.1_Silent_p.A1031A|MOV10L1_ENST00000395843.1_Silent_p.A94A|MOV10L1_ENST00000395852.1_Silent_p.A178A|MOV10L1_ENST00000395858.3_Silent_p.A1051A|MOV10L1_ENST00000354853.2_Silent_p.A94A	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	1051					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GCCTCCTGGCCCACAGCATCT	0.652000													13	55					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74328294	74328294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74328294C>T	ENST00000409262.3	+	9	3974	c.3974C>T	c.(3973-3975)tCg>tTg	p.S1325L		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1325							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGTGTGTTCTCGTCTGGGGAG	0.612000													9	28					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236925911	236925911	+	Missense_Mutation	SNP	G	G	A	rs142646143		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236925911G>A	ENST00000366578.4	+	21	2843	c.2677G>A	c.(2677-2679)Gat>Aat	p.D893N	ACTN2_ENST00000542672.1_Missense_Mutation_p.D893N|ACTN2_ENST00000546208.1_Missense_Mutation_p.D387N	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	893					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding	p.D893Y(2)		endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGGGGAGAGCGATCTGTGATG	0.507000													11	29					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63137657	63137657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63137657C>T	ENST00000279178.3	+	1	378	c.129C>T	c.(127-129)ttC>ttT	p.F43F	SLC22A9_ENST00000310969.4_Silent_p.F43F	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	43					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						TCACTGCATTCATACCTGGCC	0.483000													80	175					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131916027	131916027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131916027C>T	ENST00000286355.5	-	7	3994	c.1902G>A	c.(1900-1902)ggG>ggA	p.G634G	ADCY8_ENST00000377928.3_Silent_p.G634G	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	634					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CATTCTGTTTCCCCACGATAT	0.498000										HNSCC(32;0.087)			20	63					0	0	1	0	0
NFAM1	150372	broad.mit.edu	37	22	42807450	42807450	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42807450G>A	ENST00000329021.5	-	2	451	c.414C>T	c.(412-414)tcC>tcT	p.S138S		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	138	Ig-like V-type.				B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			large_intestine(1)|lung(3)	4						CTCTCACCGTGGAGTGTGGCC	0.597000													17	20					0	0	1	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307027	39307027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39307027G>A	ENST00000541347.1	-	2	1213	c.974C>T	c.(973-975)tCc>tTc	p.S325F	CX3CR1_ENST00000399220.2_Missense_Mutation_p.S325F|CX3CR1_ENST00000358309.3_Missense_Mutation_p.S357F|CX3CR1_ENST00000542107.1_Missense_Mutation_p.S325F	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	325					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		TTCAGATGAGGAGAAATCAAC	0.478000													59	110					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269485	150269485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150269485G>A	ENST00000255945.2	+	3	502	c.327G>A	c.(325-327)ctG>ctA	p.L109L	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Silent_p.L123L	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	109							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCATTCTTCTGACCTCCCCAG	0.507000													21	77					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439352	110439352	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110439352G>A	ENST00000378402.5	+	25	3071	c.2967G>A	c.(2965-2967)tgG>tgA	p.W989*		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	989					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACATCAAATGGAGAAGCACCT	0.488000										HNSCC(38;0.096)			15	32					0	0	1	0	0
VIPR1	7433	broad.mit.edu	37	3	42577767	42577767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42577767G>A	ENST00000433647.1	+	14	1869	c.1245G>A	c.(1243-1245)ctG>ctA	p.L415L	VIPR1_ENST00000543411.1_Silent_p.L408L|VIPR1_ENST00000438259.2_Silent_p.L246L|VIPR1_ENST00000325123.4_Silent_p.L456L	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	456					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		AAGTCTCCCTGGTCTGACCAC	0.726000													4	3					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731807	140731807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140731807C>T	ENST00000523390.1	+	1	1980	c.1980C>T	c.(1978-1980)ttC>ttT	p.F660F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTAATCTTCGCGGATAGCC	0.657000													40	116					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815429	106815429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106815429G>A	ENST00000407775.2	+	8	3369	c.3119G>A	c.(3118-3120)gGa>gAa	p.G1040E	ZFPM2_ENST00000520492.1_Missense_Mutation_p.G908E|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.G771E|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.G908E|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	1040					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AAAAATCGAGGAATGGTAATA	0.473000													7	47					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136584084	136584084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136584084C>T	ENST00000371872.4	-	7	1253	c.996G>A	c.(994-996)gaG>gaA	p.E332E	SARDH_ENST00000371867.1_Silent_p.E243E|SARDH_ENST00000422262.2_Silent_p.E164E|SARDH_ENST00000439388.1_Silent_p.E332E	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	332					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGGGGTTGGCCTCATAGCCAC	0.572000													25	49					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69683801	69683801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69683801G>A	ENST00000265403.7	+	2	800	c.773G>A	c.(772-774)cGa>cAa	p.R258Q	UGT2B10_ENST00000458688.2_Missense_Mutation_p.R174Q	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	258					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TGGCTTATGCGAAACTCCTGG	0.383000													71	128					0	0	1	0	0
DUSP13	51207	broad.mit.edu	37	10	76868887	76868887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76868887C>T	ENST00000372702.3	-	1	92	c.29G>A	c.(28-30)gGg>gAg	p.G10E	DUSP13_ENST00000607009.1_5'UTR|DUSP13_ENST00000372700.3_Missense_Mutation_p.G10E|DUSP13_ENST00000491677.2_5'UTR|DUSP13_ENST00000607131.1_5'UTR			Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13	10						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GTCCTCTCCCCCCAGCTCTGG	0.637000													20	31					0	0	1	0	0
CNN2	1265	broad.mit.edu	37	19	1037846	1037846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1037846C>T	ENST00000263097.4	+	7	1240	c.877C>T	c.(877-879)Ccg>Tcg	p.P293S	CNN2_ENST00000562958.2_Missense_Mutation_p.P314S|CNN2_ENST00000565096.2_Missense_Mutation_p.P282S|CNN2_ENST00000606983.1_3'UTR|CNN2_ENST00000348419.3_Missense_Mutation_p.P254S	NM_004368.2	NP_004359.1	Q99439	CNN2_HUMAN	calponin 2	293					actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCCCGGACCCGGGGGAGGT	0.657000													33	97					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20996782	20996782	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20996782C>T	ENST00000261383.3	-	48	7281	c.7282G>A	c.(7282-7284)Ggc>Agc	p.G2428S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2428	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGCAGGTGGCCTTTGTCCTGC	0.542000													21	33					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91312713	91312713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91312713C>T	ENST00000355112.3	+	12	2570	c.2452C>T	c.(2452-2454)Cgc>Tgc	p.R818C	BLM_ENST00000560509.1_Missense_Mutation_p.R818C|BLM_ENST00000560136.1_3'UTR	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	818	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GAATATGCTTCGCCAGAAGTT	0.428000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				65	92					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170062088	170062088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170062088C>T	ENST00000263816.3	-	41	7901	c.7616G>A	c.(7615-7617)gGa>gAa	p.G2539E		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2539					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GCGGAAGTTTCCTCCCAATGT	0.493000													32	95					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228559458	228559458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228559458C>T	ENST00000570156.2	+	105	23924	c.23850C>T	c.(23848-23850)gcC>gcT	p.A7950A	OBSCN_ENST00000366707.4_Silent_p.A4627A|OBSCN_ENST00000422127.1_Silent_p.A6993A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6993					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCGGGGGGGCCCCTATCAGGG	0.692000													8	46					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100677717	100677717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100677717C>T	ENST00000306151.4	+	3	3084	c.3020C>T	c.(3019-3021)cCt>cTt	p.P1007L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1007	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAACAACTCCTGTTGACTCC	0.522000													195	550					0	0	1	0	0
PRSS50	29122	broad.mit.edu	37	3	46757161	46757161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46757161G>A	ENST00000460241.1	-	8	2004	c.334C>T	c.(334-336)Ccc>Tcc	p.P112S	PRSS50_ENST00000315170.7_Missense_Mutation_p.P112S			Q9UI38	TSP50_HUMAN	protease, serine, 50	112	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						CTGAGGGTGGGGTCCTGCTCG	0.637000													3	13					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14368958	14368958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14368958C>T	ENST00000344204.4	+	17	3040	c.3016C>T	c.(3016-3018)Cgc>Tgc	p.R1006C	TRIO_ENST00000537187.1_Missense_Mutation_p.R1006C|TRIO_ENST00000509967.2_Missense_Mutation_p.R957C	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1006					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GATGGAAGATCGCCTCAAGCT	0.532000													41	98					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10689727	10689727	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:10689727G>T	ENST00000302079.6	-	45	7083	c.7084C>A	c.(7084-7086)Ctg>Atg	p.L2362M	PIEZO2_ENST00000538948.1_Missense_Mutation_p.L319M|PIEZO2_ENST00000285141.4_Missense_Mutation_p.L217M|PIEZO2_ENST00000580640.1_Missense_Mutation_p.L2387M|PIEZO2_ENST00000503781.3_Missense_Mutation_p.L2362M			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2362						integral to membrane	ion channel activity										CAGCTGGACAGGCTCAAAGTT	0.527000													9	78					2.17888e-05	2.18284e-05	1	1	0
GLI2	2736	broad.mit.edu	37	2	121747721	121747721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:121747721G>A	ENST00000452319.1	+	14	4291	c.4231G>A	c.(4231-4233)Gaa>Aaa	p.E1411K	GLI2_ENST00000361492.4_Missense_Mutation_p.E1411K|GLI2_ENST00000314490.11_Intron			P10070	GLI2_HUMAN	GLI family zinc finger 2	1411					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GTCCAGTCAGGAAACAGCAGA	0.697000													11	35					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109935691	109935691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109935691C>T	ENST00000342494.3	+	10	1377	c.782C>T	c.(781-783)cCt>cTt	p.P261L	UBE3B_ENST00000280774.5_Missense_Mutation_p.P261L|UBE3B_ENST00000434735.2_Missense_Mutation_p.P261L	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	261					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						ATGTCTGTGCCTGCTCTGGTG	0.478000													29	89					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404085	124404085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:124404085G>A	ENST00000303921.2	-	1	1596	c.946C>T	c.(946-948)Ccg>Tcg	p.P316S		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	316						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						ATGACCAGCGGAAGGCAGAAG	0.537000													62	131					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229772115	229772115	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:229772115C>T	ENST00000258243.2	+	4	1891	c.1755C>T	c.(1753-1755)gcC>gcT	p.A585A		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	585						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						CCCTGCTGGCCCTTCTCCCGG	0.617000													55	148					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36218811	36218811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36218811C>T	ENST00000420124.1	+	18	4422	c.4422C>T	c.(4420-4422)atC>atT	p.I1474I	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Silent_p.I1474I																							TGGTGGGCATCCTCATGCGGC	0.627000													8	13					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142612703	142612703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142612703C>T	ENST00000265310.1	-	9	1506	c.1158G>A	c.(1156-1158)ctG>ctA	p.L386L		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	386					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity	p.L386L(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCTCCCCCACCAGCCTGATGA	0.537000													12	38					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136062737	136062737	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:136062737G>C	ENST00000383202.2	-	30	3639	c.3383C>G	c.(3382-3384)cCc>cGc	p.P1128R	STAG1_ENST00000434713.2_Missense_Mutation_p.P868R|STAG1_ENST00000536929.1_Missense_Mutation_p.P712R|STAG1_ENST00000236698.5_Missense_Mutation_p.P1128R	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1128					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GTCTCCCATGGGCCGACTGTT	0.468000													28	85					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898704	36898704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36898704C>T	ENST00000301807.6	-	12	2624	c.727G>A	c.(727-729)Gag>Aag	p.E243K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E793K|TRANK1_ENST00000428977.2_Missense_Mutation_p.E243K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	793					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GAAGTGCACTCGATCTCCCAG	0.493000													105	268					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121279119	121279119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121279119G>A	ENST00000297848.3	+	25	3340	c.3070G>A	c.(3070-3072)Gaa>Aaa	p.E1024K	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.E1024K|COL14A1_ENST00000247781.3_Missense_Mutation_p.E929K	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1024					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACCAGCAAAAGAAGGTAAAAG	0.363000													28	167					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39087490	39087490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:39087490G>A	ENST00000331366.5	-	15	1208	c.1112C>T	c.(1111-1113)cCa>cTa	p.P371L	CPNE8_ENST00000538596.2_Missense_Mutation_p.P40L|CPNE8_ENST00000360449.3_Missense_Mutation_p.P359L	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	371	VWFA.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CCTTCCATCTGGAGGCAGTTT	0.348000													19	133					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79392661	79392661	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:79392661G>A	ENST00000370742.3	-	8	1056	c.993C>T	c.(991-993)gtC>gtT	p.V331V		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	331					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CTGAAGATATGACTCTTTCCT	0.318000													25	71					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22675776	22675776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:22675776C>T	ENST00000376603.2	+	5	936	c.794C>T	c.(793-795)tCg>tTg	p.S265L	SPAG6_ENST00000376624.3_Missense_Mutation_p.S189L|SPAG6_ENST00000538630.1_Missense_Mutation_p.S164L|SPAG6_ENST00000313311.6_Missense_Mutation_p.S189L|SPAG6_ENST00000376601.1_Intron|RP11-301N24.3_ENST00000422675.1_RNA			O75602	SPAG6_HUMAN	sperm associated antigen 6	189					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						ATTGCTGCTTCGGCCCTCAGT	0.483000													17	91					0	0	1	0	0
HS1BP3	64342	broad.mit.edu	37	2	20838369	20838369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:20838369G>A	ENST00000402541.1	-	4	464	c.450C>T	c.(448-450)tcC>tcT	p.S150S	HS1BP3_ENST00000304031.3_Silent_p.S150S			Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	150					cell communication		phosphatidylinositol binding			endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	15	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGGACAGAGGAATCTCTGC	0.567000													16	43					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86523440	86523440	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:86523440G>A	ENST00000297814.2	-	3	569	c.426C>T	c.(424-426)gaC>gaT	p.D142D	KIF27_ENST00000334204.2_Silent_p.D142D|KIF27_ENST00000413982.1_Silent_p.D142D	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	142	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						GATCTCTTAGGTCTTCCTTGT	0.363000													32	112					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159688919	159688919	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159688919G>A	ENST00000297267.9	+	22	5730	c.5530G>A	c.(5530-5532)Ggg>Agg	p.G1844R	FNDC1_ENST00000340366.6_Missense_Mutation_p.G1781R	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1844						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TGGAAGAACAGGGCCTCAGTC	0.438000													5	16					0	0	1	0	0
KBTBD11	9920	broad.mit.edu	37	8	1950698	1950698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1950698C>T	ENST00000320248.3	+	2	2306	c.1340C>T	c.(1339-1341)gCc>gTc	p.A447V		NM_014867.2	NP_055682.1	O94819	KBTBB_HUMAN	kelch repeat and BTB (POZ) domain containing 11	447										lung(1)|pancreas(1)	2		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.72e-05)|READ - Rectum adenocarcinoma(644;0.0929)|COAD - Colon adenocarcinoma(149;0.134)		ggcgccTTCGCCGTGGCGCAT	0.736000													3	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179659733	179659733	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179659733G>A	ENST00000589042.1	-	7	1385	c.1161C>T	c.(1159-1161)acC>acT	p.T387T	TTN_ENST00000342992.6_Silent_p.T387T|TTN_ENST00000360870.5_Silent_p.T387T|TTN_ENST00000591111.1_Silent_p.T387T|TTN_ENST00000342175.6_Silent_p.T387T|TTN_ENST00000359218.5_Silent_p.T387T|TTN_ENST00000460472.2_Silent_p.T387T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	387							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACCACTGATGGTCACTTGCT	0.557000													24	73					0	0	1	0	0
AQP10	89872	broad.mit.edu	37	1	154296130	154296130	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154296130C>T	ENST00000484864.1	+	5	591	c.555C>T	c.(553-555)gtC>gtT	p.V185V	AQP10_ENST00000355197.4_3'UTR|AQP10_ENST00000324978.3_Silent_p.V185V			Q96PS8	AQP10_HUMAN	aquaporin 10	185					response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|stomach(2)|upper_aerodigestive_tract(1)	23	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACAAGGGAGTCCCTGCGGGTC	0.622000													47	142					0	0	1	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686626	108686626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108686626C>T	ENST00000312143.7	-	3	477	c.114G>A	c.(112-114)gtG>gtA	p.V38V	CMKLR1_ENST00000550402.1_Silent_p.V38V|CMKLR1_ENST00000397688.2_Silent_p.V36V|CMKLR1_ENST00000552995.1_Silent_p.V36V|CMKLR1_ENST00000412676.1_Silent_p.V38V	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	38					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						AGATCCTGGTCACCCTGGCTT	0.473000													20	47					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43596891	43596891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:43596891G>A	ENST00000292246.3	-	10	1717	c.1547C>T	c.(1546-1548)cCa>cTa	p.P516L	ANO10_ENST00000414522.2_Missense_Mutation_p.P516L|ANO10_ENST00000451430.2_Missense_Mutation_p.P405L|ANO10_ENST00000350459.4_Missense_Mutation_p.P326L|ANO10_ENST00000396091.3_Missense_Mutation_p.P450L	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	516					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						AGCTGCTAATGGGTAAACACA	0.383000													24	83					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37256298	37256298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37256298C>T	ENST00000310758.4	-	11	1430	c.783G>A	c.(781-783)gaG>gaA	p.E261E	ELMO1_ENST00000448602.1_Silent_p.E261E|ELMO1_ENST00000442504.1_Silent_p.E261E	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	261					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TATTCGCCATCTCCTGTGGAA	0.478000													31	69					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25448272	25448272	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25448272G>A	ENST00000424208.1	+	0	2118				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CTGGTGTGCTGAAGCTCAGGC	0.642000													33	66					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39226093	39226093	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39226093A>G	ENST00000340369.3	-	2	5072	c.4844T>C	c.(4843-4845)gTt>gCt	p.V1615A	XIRP1_ENST00000421646.1_Missense_Mutation_p.V298A|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1615							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTGGCATTCAACCTTGGCTTG	0.572000													48	134					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44983754	44983754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44983754G>A	ENST00000372227.1	-	6	1075	c.535C>T	c.(535-537)Cgc>Tgc	p.R179C	SLC35C2_ENST00000543605.1_Missense_Mutation_p.R208C|SLC35C2_ENST00000317734.8_Missense_Mutation_p.R158C|SLC35C2_ENST00000372230.5_Missense_Mutation_p.R179C|SLC35C2_ENST00000372229.1_Missense_Mutation_p.R46C|SLC35C2_ENST00000243896.2_Missense_Mutation_p.R179C			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	179					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				AGGGTCCAGCGAATGCCACCG	0.622000													33	94					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774677	121774677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121774677C>T	ENST00000264808.3	-	3	436	c.196G>A	c.(196-198)Gaa>Aaa	p.E66K	PRDM5_ENST00000428209.2_Missense_Mutation_p.E66K|PRDM5_ENST00000515109.1_Missense_Mutation_p.E66K|PRDM5_ENST00000394435.2_Missense_Mutation_p.E66K	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	66	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TACAAAACTTCTCCCTTACTC	0.453000													68	307					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10140504	10140504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10140504C>T	ENST00000287647.3	+	43	4379	c.4286C>T	c.(4285-4287)tCt>tTt	p.S1429F	FANCD2_ENST00000383807.1_Intron|FANCD2_ENST00000419585.1_Intron|FANCD2_ENST00000383806.1_Intron|FANCD2OS_ENST00000524279.1_Intron	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1429					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ACTGAGGTATCTCTACAAAAC	0.448000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				32	68					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121488	27121488	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27121488G>A	ENST00000288699.6	+	2	279	c.121G>A	c.(121-123)Gag>Aag	p.E41K	DPYSL5_ENST00000401478.1_Missense_Mutation_p.E41K	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	41					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGGGCCGCGAGCTCATGAT	0.582000													23	67					0	0	1	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47653014	47653014	+	Silent	SNP	G	G	A	rs17850898		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47653014G>A	ENST00000294338.2	-	2	275	c.153C>T	c.(151-153)aaC>aaT	p.N51N	PDZK1IP1_ENST00000371885.1_Silent_p.N51N	NM_005764.3	NP_005755.1	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	51				N -> K (in Ref. 5; AAH12303).		integral to membrane				endometrium(1)|lung(1)|prostate(1)	3						ACCAGAAGTGGTTGACTGCAA	0.612000													14	38					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96824616	96824616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96824616G>A	ENST00000371270.3	-	4	677	c.583C>T	c.(583-585)Ctc>Ttc	p.L195F	CYP2C8_ENST00000535898.1_Missense_Mutation_p.L93F|CYP2C8_ENST00000539050.1_Missense_Mutation_p.L109F	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	195					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding	p.L195V(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	ATCAGGGTGAGAAAATTCTGA	0.408000													26	97					0	0	1	0	0
SLC38A1	81539	broad.mit.edu	37	12	46633526	46633526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:46633526C>T	ENST00000398637.5	-	3	752	c.58G>A	c.(58-60)Gag>Aag	p.E20K	SLC38A1_ENST00000546893.1_Missense_Mutation_p.E20K|SLC38A1_ENST00000549633.1_Intron|SLC38A1_ENST00000549049.1_Missense_Mutation_p.E20K|SLC38A1_ENST00000439706.1_Missense_Mutation_p.E20K|SLC38A1_ENST00000552197.1_Missense_Mutation_p.E20K	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	20					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			TTATCATCCTCGGGCACTGTC	0.353000													29	104					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226733	158226733	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158226733C>T	ENST00000289429.5	+	4	1295	c.762C>T	c.(760-762)ccC>ccT	p.P254P		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	254	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	ACATCTTGCCCAGTGCTGATG	0.622000													23	109					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179733990	179733990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179733990C>T	ENST00000420890.2	-	15	2365	c.2248G>A	c.(2248-2250)Gag>Aag	p.E750K	CCDC141_ENST00000295723.5_Missense_Mutation_p.E175K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	175							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCAGTTAACTCCTCTGATTCT	0.338000													9	64					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743049	26743049	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26743049A>G	ENST00000396005.3	-	1	522	c.213T>C	c.(211-213)ccT>ccC	p.P71P	SLC5A12_ENST00000280467.6_Silent_p.P71P	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	71					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						AGACTTCAGAAGGGGTCCCCA	0.522000													21	63					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40773171	40773171	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40773171C>T	ENST00000372748.3	-	19	1051	c.954_splice	c.e19-1	p.G319_splice		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	319	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CCTGCACTGCCCTGGGATAGA	0.592000													10	23					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234873392	234873392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234873392C>T	ENST00000324695.4	+	14	1910	c.1870C>T	c.(1870-1872)Cgg>Tgg	p.R624W	TRPM8_ENST00000433712.2_Missense_Mutation_p.R312W	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	624						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTACGAGACCCGGGCTGTTGG	0.582000													20	72					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128896701	128896701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:128896701G>A	ENST00000371106.3	+	19	1887	c.1695G>A	c.(1693-1695)ggG>ggA	p.G565G		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	565					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						GAGAATTTGGGATCCGTCTCG	0.542000													36	24					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74328067	74328067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74328067C>T	ENST00000409262.3	+	9	3747	c.3747C>T	c.(3745-3747)ccC>ccT	p.P1249P		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1249							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ACCCCTCCCCCTTTGCCCAGA	0.622000													5	9					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115544705	115544705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:115544705C>T	ENST00000310836.6	+	2	1191	c.669C>T	c.(667-669)aaC>aaT	p.N223N	UGT8_ENST00000394511.3_Silent_p.N223N	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	223					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		AGAAGTACAACCTGCTGCCAG	0.463000													44	78					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62289169	62289169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:62289169C>T	ENST00000519846.1	+	4	933	c.461C>T	c.(460-462)tCc>tTc	p.S154F	CLVS1_ENST00000325897.4_Missense_Mutation_p.S154F|CLVS1_ENST00000518592.1_5'UTR			Q8IUQ0	CLVS1_HUMAN	clavesin 1	154	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TGCAGGAACTCCTTCACAGAC	0.493000													16	95					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553072	140553072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140553072C>T	ENST00000231137.3	+	1	830	c.656C>T	c.(655-657)tCt>tTt	p.S219F		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		219	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACGGCGGCTCTCCTCCAAGA	0.547000													20	68					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657294	72657294	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72657294C>T	ENST00000425256.1	-	0	2617					NR_002164.1																						caggagttttctctccatcgc	0.448000													45	82					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354073	57354073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57354073C>T	ENST00000314922.3	-	2	638	c.562G>A	c.(562-564)Ggc>Agc	p.G188S	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.G188S	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	188					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CTCATGAAGCCCCCATATCTC	0.517000													53	130					0	0	1	0	0
GLRA1	2741	broad.mit.edu	37	5	151304099	151304099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:151304099G>A	ENST00000274576.4	-	1	304	c.12C>T	c.(10-12)ttC>ttT	p.F4F	GLRA1_ENST00000455880.2_Silent_p.F4F|GLRA1_ENST00000545569.1_5'UTR|GLRA1_ENST00000471351.2_5'UTR	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	4					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAAGAGTATTGAAGCTGTACA	0.428000													34	139					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71465309	71465309	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71465309C>T	ENST00000322937.6	+	5	343	c.240C>T	c.(238-240)ctC>ctT	p.L80L	AMBN_ENST00000449493.2_Silent_p.L80L	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	80					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			ACGGTCTCCTCCCACCACATT	0.373000													24	61					0	0	1	0	0
HMGCS2	3158	broad.mit.edu	37	1	120301848	120301848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120301848G>A	ENST00000369406.3	-	4	792	c.743C>T	c.(742-744)tCg>tTg	p.S248L	HMGCS2_ENST00000476640.1_Intron|HMGCS2_ENST00000544913.2_Missense_Mutation_p.S206L	NM_005518.3	NP_005509.1	P54868	HMCS2_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	248					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		TGGGTACTCCGAGGCCAAATT	0.468000													36	69					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124345685	124345685	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124345685G>A	ENST00000338354.3	+	16	1675	c.1569G>A	c.(1567-1569)tgG>tgA	p.W523*	DMBT1_ENST00000344338.3_Nonsense_Mutation_p.W513*|DMBT1_ENST00000368955.3_Nonsense_Mutation_p.W513*|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368909.3_Nonsense_Mutation_p.W523*			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	523	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATGACAGCTGGGACACCAATG	0.617000													161	376					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77431653	77431653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77431653G>A	ENST00000451710.3	-	11	1477	c.1240C>T	c.(1240-1242)Ctg>Ttg	p.L414L	TRPM6_ENST00000376864.4_Silent_p.L414L|TRPM6_ENST00000361255.3_Silent_p.L409L|TRPM6_ENST00000360774.1_Silent_p.L414L|TRPM6_ENST00000376871.3_Silent_p.L414L|TRPM6_ENST00000376872.3_Silent_p.L414L|TRPM6_ENST00000449912.2_Silent_p.L409L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	414					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GCCATTGCCAGATTTAATTGC	0.363000													24	78					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64116835	64116835	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64116835G>A	ENST00000301897.4	+	0	1017				CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000356786.5_Silent_p.E883E|CCDC88B_ENST00000359902.2_Silent_p.E35E			A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B						microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGGGCAAGGAGTTGGGGGACC	0.637000													7	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069180	9069180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9069180G>A	ENST00000397910.4	-	3	18469	c.18266C>T	c.(18265-18267)tCa>tTa	p.S6089L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6091	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTGTAGTTGAGTTCATCAC	0.488000													15	30					0	0	1	0	0
PTHLH	5744	broad.mit.edu	37	12	28116375	28116375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:28116375G>A	ENST00000535992.1	-	3	776	c.430C>T	c.(430-432)Cgc>Tgc	p.R144C	PTHLH_ENST00000539239.1_Missense_Mutation_p.R144C|PTHLH_ENST00000538310.1_Missense_Mutation_p.R144C|PTHLH_ENST00000395872.1_Missense_Mutation_p.R144C|PTHLH_ENST00000395868.3_Missense_Mutation_p.R144C|RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000354417.3_Missense_Mutation_p.R144C|PTHLH_ENST00000545234.1_Missense_Mutation_p.R144C|PTHLH_ENST00000201015.4_Missense_Mutation_p.R144C			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	144					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					CAGGCAGAGCGAGTTCGCCGT	0.552000													35	74					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488194	24488194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:24488194C>T	ENST00000264463.4	-	12	2452	c.1945G>A	c.(1945-1947)Gat>Aat	p.D649N	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	649					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TCTCTGATATCTTCTTTTGAC	0.433000										HNSCC(23;0.051)			18	87					0	0	1	0	0
CHST1	8534	broad.mit.edu	37	11	45671842	45671842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:45671842G>A	ENST00000308064.2	-	4	1302	c.632C>T	c.(631-633)cCc>cTc	p.P211L		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	211					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GTTCACCTCGGGCACGCGCAC	0.682000													27	23					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420360	55420360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55420360G>A	ENST00000242994.3	+	2	515	c.137G>A	c.(136-138)aGc>aAc	p.S46N		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	46					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						ATGCTCAGCAGCTTAACTGAA	0.468000													18	43					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113955458	113955458	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113955458G>A	ENST00000245796.6	+	14	2787	c.2592G>A	c.(2590-2592)acG>acA	p.T864T	PSD4_ENST00000441564.2_Silent_p.T835T	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	864	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCTGCGCACGGCTGACTGGC	0.657000													11	23					0	0	1	0	0
UPK3A	7380	broad.mit.edu	37	22	45689189	45689189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45689189C>T	ENST00000216211.4	+	5	731	c.699C>T	c.(697-699)agC>agT	p.S233S	UPK3A_ENST00000396082.2_Silent_p.S112S	NM_006953.3	NP_008884.1	O75631	UPK3A_HUMAN	uroplakin 3A	233					epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane				kidney(1)|large_intestine(1)|lung(2)|skin(1)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TTGCCCTCAGCCTCGTGTAAG	0.632000													25	74					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148932899	148932899	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:148932899G>A	ENST00000539543.1	+	0	155					NR_027355.1																						CTCAGTCTGCGGCCAAGACTC	0.617000													8	148					0	0	1	0	0
FSTL1	11167	broad.mit.edu	37	3	120122201	120122201	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120122201C>T	ENST00000295633.3	-	8	938	c.581_splice	c.e8-1	p.R194_splice	FSTL1_ENST00000424703.2_Splice_Site_p.R159_splice	NM_007085.4	NP_009016.1	Q12841	FSTL1_HUMAN	follistatin-like 1	194	EF-hand 2.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		CACAGAGTCCCCTGAAACAAA	0.468000													5	67					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105173304	105173304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105173304C>T	ENST00000392634.4	+	7	1013	c.901C>T	c.(901-903)Ctg>Ttg	p.L301L	INF2_ENST00000330634.7_Silent_p.L301L	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	301	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CCTCCTGCACCTGGAGCCCAC	0.726000													7	17					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94927321	94927321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94927321C>T	ENST00000357742.4	+	12	1653	c.1653C>T	c.(1651-1653)aaC>aaT	p.N551N	MCTP2_ENST00000557742.1_Silent_p.N139N|MCTP2_ENST00000451018.3_Silent_p.N551N|MCTP2_ENST00000331706.4_Silent_p.N139N	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	551	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TCTACAAAAACCTCAACCCTG	0.438000													21	27					0	0	1	0	0
EXO1	9156	broad.mit.edu	37	1	242042065	242042065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:242042065C>T	ENST00000366548.3	+	13	2122	c.1529C>T	c.(1528-1530)tCa>tTa	p.S510L	EXO1_ENST00000518483.1_Missense_Mutation_p.S510L|EXO1_ENST00000348581.5_Missense_Mutation_p.S510L	NM_130398.3	NP_569082.2	Q9UQ84	EXO1_HUMAN	exonuclease 1	510					meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TTTTGCAGTTCAGATTCTACT	0.343000								Editing and processing nucleases					12	31					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10602129	10602129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10602129C>T	ENST00000547195.1	-	19	2595	c.2095G>A	c.(2095-2097)Gaa>Aaa	p.E699K	LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000541483.1_Missense_Mutation_p.E584K|MRVI1_ENST00000421747.1_Missense_Mutation_p.E781K|MRVI1_ENST00000423302.2_Missense_Mutation_p.E790K|MRVI1_ENST00000436272.1_Missense_Mutation_p.E763K|MRVI1_ENST00000534266.2_Missense_Mutation_p.E475K|MRVI1-AS1_ENST00000529979.1_RNA|MRVI1_ENST00000424001.1_Missense_Mutation_p.E475K|MRVI1_ENST00000531107.1_Missense_Mutation_p.E782K|MRVI1_ENST00000527509.2_Missense_Mutation_p.E699K|MRVI1_ENST00000558540.1_Missense_Mutation_p.E475K|MRVI1_ENST00000552103.1_Missense_Mutation_p.E699K|MRVI1-AS1_ENST00000529829.1_RNA|MRVI1_ENST00000545852.1_Missense_Mutation_p.E475K	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	763					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTTAGACCTTCTTGGAATCTG	0.498000													14	107					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76332544	76332544	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76332544C>T	ENST00000312916.7	+	4	1062	c.681_splice	c.e4+1	p.S227_splice		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	227					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		TATTATGATTCTGTAAGTATC	0.438000													6	79					0	0	1	0	0
FAM126A	84668	broad.mit.edu	37	7	22999935	22999935	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:22999935G>A	ENST00000432176.2	-	10	1163	c.931C>T	c.(931-933)Cga>Tga	p.R311*	FAM126A_ENST00000498833.1_5'UTR|FAM126A_ENST00000409923.1_Nonsense_Mutation_p.R311*	NM_032581.3	NP_115970.2	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	311						cytoplasm|membrane	signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|urinary_tract(2)	23						CTTGATATTCGAGAGGAAGTT	0.388000													41	226					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39087397	39087397	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39087397G>A	ENST00000400482.3	-	3	652	c.63C>T	c.(61-63)gtC>gtT	p.V21V	KCNJ6_ENST00000288309.6_Silent_p.V21V	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	21					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CTGGGCTTTCGACGTCCTGAT	0.517000													22	29					0	0	1	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113202003	113202003	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113202003G>A	ENST00000261965.3	-	10	1285	c.1099C>T	c.(1099-1101)Ctc>Ttc	p.L367F	TUBGCP3_ENST00000375669.3_Missense_Mutation_p.L367F	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	367					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CAAACCAGGAGGCGCCGAAGT	0.473000													11	60					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175117	140175117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140175117G>A	ENST00000526136.1	+	1	568	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	PCDHA2_ENST00000378132.1_Missense_Mutation_p.E190K|PCDHA2_ENST00000520672.2_Missense_Mutation_p.E190K|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1												p.E190K(4)		NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACTAAGCGAATCTTTGTC	0.458000													38	93					0	0	1	0	0
SUSD4	55061	broad.mit.edu	37	1	223465828	223465828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:223465828C>T	ENST00000343846.3	-	2	947	c.314G>A	c.(313-315)gGa>gAa	p.G105E	SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000454695.2_5'UTR|SUSD4_ENST00000344029.6_Missense_Mutation_p.G105E|SUSD4_ENST00000366878.4_Missense_Mutation_p.G105E			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	105	Sushi 1.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GCCTAGGGTTCCATTAAAATG	0.478000													65	146					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169550939	169550939	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169550939G>A	ENST00000340806.6	+	4	1498	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	500										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ATACCTCAAGGAAAACAGAAA	0.408000													12	29					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603012	111603012	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111603012G>A	ENST00000431670.2	+	2	499	c.88G>A	c.(88-90)Gat>Aat	p.D30N	PHLDB2_ENST00000412622.1_Missense_Mutation_p.D30N|PHLDB2_ENST00000477695.1_Missense_Mutation_p.D30N|PHLDB2_ENST00000481953.1_Missense_Mutation_p.D30N|PHLDB2_ENST00000393925.3_Missense_Mutation_p.D30N|PHLDB2_ENST00000478922.1_Missense_Mutation_p.D30N|PHLDB2_ENST00000393923.3_Missense_Mutation_p.D57N	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	30						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TGTTGAGAACGATTCCCAAAA	0.418000													68	154					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203676168	203676168	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203676168C>T	ENST00000357681.5	+	9	2254	c.1131C>T	c.(1129-1131)atC>atT	p.I377I	ATP2B4_ENST00000391954.2_Silent_p.I377I|ATP2B4_ENST00000367219.3_Silent_p.I365I|ATP2B4_ENST00000341360.2_Silent_p.I377I|ATP2B4_ENST00000367218.3_Silent_p.I377I	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	377					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CGGTTTTCATCCTGATTCTAT	0.468000													10	32					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102500749	102500749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102500749C>T	ENST00000360184.4	+	56	10878	c.10714C>T	c.(10714-10716)Ctt>Ttt	p.L3572F	DYNC1H1_ENST00000556791.1_3'UTR	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3572	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TGCTGATGACCTTTGCACAGA	0.502000													17	75					0	0	1	0	0
SMR3B	10879	broad.mit.edu	37	4	71255522	71255522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71255522C>T	ENST00000304915.3	+	3	346	c.197C>T	c.(196-198)cCc>cTc	p.P66L	SMR3B_ENST00000504825.1_Missense_Mutation_p.P66L	NM_006685.3	NP_006676.1			submaxillary gland androgen regulated protein 3B											large_intestine(2)|lung(3)|skin(2)	7		all_hematologic(202;0.196)				CCTCCCGCACCCTATGGTCCA	0.597000													47	117					0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2511789	2511789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2511789C>T	ENST00000569496.1	+	5	706	c.647C>T	c.(646-648)tCc>tTc	p.S216F	C16orf59_ENST00000563531.1_Missense_Mutation_p.S216F|C16orf59_ENST00000483320.1_Missense_Mutation_p.S49F|C16orf59_ENST00000361837.4_Missense_Mutation_p.S216F			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	216										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				AAAGCAGCTTCCCAGAACTCG	0.612000													16	79					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145583638	145583638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145583638C>T	ENST00000532887.1	+	3	1069	c.486C>T	c.(484-486)gcC>gcT	p.A162A	SLC52A2_ENST00000540505.1_Silent_p.A74A|SLC52A2_ENST00000329994.2_Silent_p.A162A|SLC52A2_ENST00000402965.1_Silent_p.A162A|SLC52A2_ENST00000527078.1_Silent_p.A162A|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000526891.1_3'UTR|SLC52A2_ENST00000530047.1_Silent_p.A162A			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	162						integral to plasma membrane	receptor activity|riboflavin transporter activity										GCGTGCTGGCCCTAGTGCAGG	0.652000													47	112					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769170	140769170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140769170C>T	ENST00000519479.1	+	1	1719	c.1719C>T	c.(1717-1719)ttC>ttT	p.F573F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1												p.F573F(1)		endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGCTCTTCGATATGGTGC	0.647000													5	57					0	0	1	0	0
OXTR	5021	broad.mit.edu	37	3	8794856	8794856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:8794856G>A	ENST00000316793.3	-	4	1601	c.977C>T	c.(976-978)cCc>cTc	p.P326L	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	326					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GTAGATCCAGGGGTTGCAGCA	0.597000													11	80					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18624985	18624985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18624985C>T	ENST00000406451.3	+	3	254	c.104C>T	c.(103-105)cCc>cTc	p.P35L	HDAC9_ENST00000401921.1_Missense_Mutation_p.P35L|HDAC9_ENST00000406072.1_Missense_Mutation_p.P63L|HDAC9_ENST00000417496.2_Missense_Mutation_p.P77L|HDAC9_ENST00000476135.1_3'UTR|HDAC9_ENST00000428307.2_Missense_Mutation_p.P35L|HDAC9_ENST00000456174.2_Missense_Mutation_p.P4L|HDAC9_ENST00000524023.1_Missense_Mutation_p.P4L|HDAC9_ENST00000441542.2_Missense_Mutation_p.P35L|HDAC9_ENST00000405010.3_Missense_Mutation_p.P35L|HDAC9_ENST00000432645.2_Missense_Mutation_p.P35L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	35					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	ATGATGATGCCCGTGGTGGAC	0.478000													53	119					0	0	1	0	0
C10orf107	219621	broad.mit.edu	37	10	63519931	63519931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:63519931G>A	ENST00000330194.2	+	5	708	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K		NM_173554.2	NP_775825.1	Q8IVU9	CJ107_HUMAN	chromosome 10 open reading frame 107	135										breast(1)|kidney(1)|lung(4)|prostate(1)|skin(1)	8	Prostate(12;0.016)					ATTGGATACGGAAATGAAGGT	0.383000													18	70					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32050005	32050005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32050005G>A	ENST00000375244.3	-	9	3745	c.3544C>T	c.(3544-3546)Cct>Tct	p.P1182S	TNXB_ENST00000375247.2_Missense_Mutation_p.P1182S			P22105	TENX_HUMAN	tenascin XB	1269	Fibronectin type-III 4.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TGGCCCTCAGGGACAGTCCAG	0.597000													12	43					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129752087	129752087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:129752087G>A	ENST00000446488.3	-	10	1188	c.1085C>T	c.(1084-1086)cCc>cTc	p.P362L	NFRKB_ENST00000304521.5_Missense_Mutation_p.P362L|NFRKB_ENST00000524746.1_Missense_Mutation_p.P362L|NFRKB_ENST00000524794.1_Missense_Mutation_p.P387L	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	362					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GTCTTCAAGGGGCCTAATGAG	0.438000													12	32					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159778947	159778947	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159778947G>A	ENST00000321935.6	+	5	623	c.537G>A	c.(535-537)gaG>gaA	p.E179E	FCRL6_ENST00000392235.3_Intron|FCRL6_ENST00000339348.5_Silent_p.E172E|FCRL6_ENST00000368106.3_Silent_p.E172E			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	172	Ig-like C2-type 2.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					GAGCCAAGGAGGGAGACTCTG	0.627000													15	57					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439945	150439945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150439945G>A	ENST00000358647.3	+	3	1085	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGCCTGCCAGGAAGACTACAG	0.577000													20	67					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11589616	11589616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11589616G>A	ENST00000294484.6	+	14	2940	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	PTCHD2_ENST00000389575.3_Silent_p.K934K	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	934					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCCACAGGAAGCTGTACTTCG	0.667000													41	85					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57859574	57859574	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57859574C>T	ENST00000228682.2	+	7	719	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S	GLI1_ENST00000546141.1_Missense_Mutation_p.P169S|GLI1_ENST00000543426.1_Missense_Mutation_p.P82S	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	210			P -> A (in a breast cancer sample; somatic mutation).		epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding	p.P210A(1)		NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			GCCCTAGGATCCCCTGTTGGG	0.557000													32	89					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587770	36587770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36587770G>A	ENST00000332987.1	-	7	819	c.397C>T	c.(397-399)Cac>Tac	p.H133Y	APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000352371.1_Missense_Mutation_p.H136Y			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	137					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						CAGCCTCTGTGGACCTTTTCA	0.483000													12	74					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171700565	171700565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171700565G>A	ENST00000358196.3	+	7	1199	c.649G>A	c.(649-651)Gaa>Aaa	p.E217K	GAD1_ENST00000429023.1_3'UTR	NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	217					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GTTTACATATGAAATTGCACC	0.358000													18	59					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21901519	21901519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21901519G>A	ENST00000328843.6	+	70	11303	c.11272G>A	c.(11272-11274)Gaa>Aaa	p.E3758K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E3751K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3758					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGACAAGGTGGAAGACATGCA	0.502000									Kartagener syndrome				16	74					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284502	152284502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152284502C>T	ENST00000368799.1	-	3	2895	c.2860G>A	c.(2860-2862)Gga>Aga	p.G954R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	954	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGAATGTCCCTCACTGTCA	0.572000									Ichthyosis				157	376					0	0	1	0	0
IFNLR1	163702	broad.mit.edu	37	1	24483953	24483953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24483953C>T	ENST00000327535.1	-	7	1242	c.1230G>A	c.(1228-1230)aaG>aaA	p.K410K	IFNLR1_ENST00000374421.3_Silent_p.K381K|IFNLR1_ENST00000327575.2_3'UTR	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1																		GGCCTGGCCCCTTCTCAGCCA	0.597000													9	80					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83129338	83129338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:83129338C>T	ENST00000329312.4	+	4	1659	c.1622C>T	c.(1621-1623)tCa>tTa	p.S541L		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	541	8 X approximate tandem repeats.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						ATCAAAGGTTCAGATACTGAA	0.373000													20	13					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186437989	186437989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186437989G>A	ENST00000265023.4	+	2	503	c.291G>A	c.(289-291)aaG>aaA	p.K97K	RP11-573D15.8_ENST00000599314.1_RNA|KNG1_ENST00000447445.1_Silent_p.K97K|KNG1_ENST00000287611.2_Silent_p.K97K	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	97	Cystatin 1.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GTGAGTACAAGGATGCTGCAA	0.453000													23	36					0	0	1	0	0
SLC7A11	23657	broad.mit.edu	37	4	139163150	139163150	+	Missense_Mutation	SNP	G	G	A	rs140307668		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:139163150G>A	ENST00000280612.5	-	1	353	c.74C>T	c.(73-75)cCt>cTt	p.P25L		NM_014331.3	NP_055146.1	Q9UPY5	XCT_HUMAN	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	25					blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)	18	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	GCCCAGGGAAGGCAGCCTCCC	0.507000													20	58					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73635892	73635892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73635892G>A	ENST00000261917.3	-	2	2036	c.1043C>T	c.(1042-1044)tCc>tTc	p.S348F		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	348					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GGGGATGGAGGAAATGAAATC	0.537000													22	62					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41055511	41055511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:41055511C>T	ENST00000324545.7	+	27	4618	c.3985C>T	c.(3985-3987)Cgt>Tgt	p.R1329C	USP9X_ENST00000378308.2_Missense_Mutation_p.R1329C	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1329					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CAGAACTGTTCGTCAGGTGGC	0.398000													52	39					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39645736	39645736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39645736G>A	ENST00000265708.4	-	9	780	c.677C>T	c.(676-678)tCt>tTt	p.S226F	ADAM2_ENST00000379853.2_Intron|ADAM2_ENST00000347580.4_Missense_Mutation_p.S207F|ADAM2_ENST00000521880.1_Missense_Mutation_p.S226F	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	226	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTCCAATGAAGACAGAATAAT	0.259000													32	66					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119962183	119962183	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119962183C>T	ENST00000543831.1	+	3	534	c.285C>T	c.(283-285)tcC>tcT	p.S95S	HSD3B2_ENST00000369416.3_Silent_p.S95S|HSD3B2_ENST00000471656.1_3'UTR	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	95					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	ACAGAGAGTCCATCATGAATG	0.463000													33	62					0	0	1	0	0
SCAMP3	10067	broad.mit.edu	37	1	155227153	155227153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155227153G>A	ENST00000355379.3	-	6	902	c.624C>T	c.(622-624)ttC>ttT	p.F208F	SCAMP3_ENST00000302631.3_Silent_p.F234F|SCAMP3_ENST00000472397.1_5'UTR	NM_052837.2	NP_443069.1	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3	234					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(7)|ovary(4)|urinary_tract(1)	19	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGAAGAAAACGAAGAAATTGA	0.488000													6	22					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41559882	41559882	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41559882G>A	ENST00000400454.1	-	13	3063	c.2586C>T	c.(2584-2586)ttC>ttT	p.F862F		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	862	Ig-like C2-type 9.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGCAGGAAAAGAAACCAGAAT	0.403000													20	55					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167675204	167675204	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167675204C>T	ENST00000519204.1	+	26	7015	c.6897C>T	c.(6895-6897)acC>acT	p.T2299T	TENM2_ENST00000545108.1_Silent_p.T2419T|TENM2_ENST00000518659.1_Silent_p.T2420T|TENM2_ENST00000520394.1_Silent_p.T2181T|TENM2_ENST00000403607.2_Silent_p.T2244T					teneurin transmembrane protein 2																		ACCCCCTGACCAAGCTGGTCC	0.547000													21	83					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70991123	70991123	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70991123G>A	ENST00000357250.6	-	8	1004	c.846C>T	c.(844-846)ccC>ccT	p.P282P	COL9A1_ENST00000370496.3_Silent_p.P282P|COL9A1_ENST00000370499.4_Silent_p.P39P|COL9A1_ENST00000320755.7_Silent_p.P39P	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	282	Triple-helical region (COL3).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GAACTCCAGGGGGGCCCGGAG	0.592000													20	17					0	0	1	0	0
CLASRP	11129	broad.mit.edu	37	19	45572499	45572499	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45572499C>T	ENST00000544944.2	+	16	2502	c.1810C>T	c.(1810-1812)Cgc>Tgc	p.R604C	CLASRP_ENST00000221455.3_Missense_Mutation_p.R623C|CLASRP_ENST00000391953.4_Missense_Mutation_p.R561C			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	623	Arg-rich.				mRNA processing|RNA splicing	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						CCGCAAGATCCGCATGAAGTA	0.667000													11	48					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36122827	36122827	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36122827T>A	ENST00000303965.4	-	23	4357	c.3868A>T	c.(3868-3870)Att>Ttt	p.I1290F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1290	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TAATTATTAATTAGGTCCTCA	0.323000													17	61					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27801932	27801932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27801932G>A	ENST00000408964.2	+	1	2544	c.2493G>A	c.(2491-2493)atG>atA	p.M831I		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	831										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GGAAGCAAATGGAGGAGCTAG	0.438000													38	103					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30963129	30963129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30963129C>T	ENST00000311813.4	+	4	750	c.695C>T	c.(694-696)gCc>gTc	p.A232V	AQP1_ENST00000434909.2_Missense_Mutation_p.A292V|AQP1_ENST00000441328.2_Missense_Mutation_p.A149V|AQP1_ENST00000409899.1_Missense_Mutation_p.A117V|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Missense_Mutation_p.A181V|AQP1_ENST00000509504.1_Missense_Mutation_p.A409V	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				TTCATCCTGGCCCCACGCAGC	0.597000													19	28					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47527654	47527654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47527654C>T	ENST00000273859.3	+	5	1040	c.771C>T	c.(769-771)ggC>ggT	p.G257G	ATP10D_ENST00000504445.1_Silent_p.G257G	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	257					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GATTCCGAGGCTTCCTGTGAG	0.378000													12	49					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882732	228882732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228882732C>T	ENST00000392056.3	-	7	2884	c.2838G>A	c.(2836-2838)gcG>gcA	p.A946A	SPHKAP_ENST00000344657.5_Silent_p.A946A	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	946	PKA-RII subunit binding domain (By similarity).					cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAAGGCAAATCGCTGCAATTT	0.473000													18	129					0	0	1	0	0
C8orf31	286122	broad.mit.edu	37	8	144126132	144126132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144126132G>A	ENST00000395172.1	+	4	605	c.253G>A	c.(253-255)Gac>Aac	p.D85N	C8orf31_ENST00000517653.1_3'UTR	NM_173687.2	NP_775958.1	Q8N9H6	CH031_HUMAN	chromosome 8 open reading frame 31	85										breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GGGAGACACAGACCCCATCCA	0.627000													16	56					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324450	79324450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79324450C>T	ENST00000428286.1	-	8	2863	c.1663G>A	c.(1663-1665)Gaa>Aaa	p.E555K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E914K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	914					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCTACCTTTTCATATACCTTG	0.398000													53	208					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57950064	57950064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57950064C>T	ENST00000564448.1	-	22	2228	c.2168G>A	c.(2167-2169)cGa>cAa	p.R723Q	CNGB1_ENST00000251102.8_Missense_Mutation_p.R729Q			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	729					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GTAGTTATTTCGCATGTCCTT	0.517000													41	93					0	0	1	0	0
SCAF8	22828	broad.mit.edu	37	6	155154119	155154119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155154119C>T	ENST00000367178.3	+	20	3982	c.3406C>T	c.(3406-3408)Cct>Tct	p.P1136S	SCAF8_ENST00000367186.4_Missense_Mutation_p.P1202S|SCAF8_ENST00000417268.1_Missense_Mutation_p.P1136S|TIAM2_ENST00000461783.3_5'UTR	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	1136	Arg-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						TAGAAGTGGTCCTTGGAACCG	0.458000													28	52					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98192614	98192614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98192614C>T	ENST00000357947.3	-	4	695	c.470G>A	c.(469-471)aGg>aAg	p.R157K	TLL2_ENST00000469598.1_Intron	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	157	Metalloprotease (By similarity).				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		AGGCCATATCCTCTCTGTCCT	0.582000													26	77					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21967619	21967619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21967619G>A	ENST00000261200.4	-	33	4060	c.4061C>T	c.(4060-4062)tCg>tTg	p.S1354L	ABCC9_ENST00000261201.4_Missense_Mutation_p.S1354L|ABCC9_ENST00000345162.2_Missense_Mutation_p.S1318L	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1354	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGAGATAACGATGATTTCCC	0.403000													10	92					0	0	1	0	0
CIB4	130106	broad.mit.edu	37	2	26863423	26863423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26863423G>A	ENST00000288861.4	-	2	120	c.67C>T	c.(67-69)Ctg>Ttg	p.L23L		NM_001029881.1	NP_001025052.1	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	23							calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTCTGGTCAGGAAGGTCAGG	0.567000													32	145					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45799080	45799080	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45799080G>A	ENST00000397928.1	+	8	1660	c.1215_splice	c.e8+1	p.K405_splice	TRPM2_ENST00000300481.9_Splice_Site_p.K405_splice|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Splice_Site_p.K405_splice|TRPM2_ENST00000397932.2_Splice_Site_p.K405_splice	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	405						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GGACCAAAAAGGTGAGGCTGA	0.557000													23	51					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52585170	52585170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52585170C>T	ENST00000591504.1	-	10	1121	c.847G>A	c.(847-849)Gaa>Aaa	p.E283K	CCDC68_ENST00000337363.4_Missense_Mutation_p.E283K|CCDC68_ENST00000432185.1_Missense_Mutation_p.E283K	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	283										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TTAACCTTTTCTCTGAGATTT	0.368000													9	25					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35556516	35556516	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35556516C>T	ENST00000262626.2	+	11	1806	c.981C>T	c.(979-981)ttC>ttT	p.F327F	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Silent_p.F169F|HPN_ENST00000392226.1_Silent_p.F327F	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	327	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GCGCTGACTTCTATGGAAACC	0.602000													38	70					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	50008373	50008373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:50008373G>A	ENST00000451037.2	-	3	1196	c.256C>T	c.(256-258)Cgc>Tgc	p.R86C	CA10_ENST00000442502.2_Missense_Mutation_p.R86C|CA10_ENST00000340813.6_Missense_Mutation_p.R92C|CA10_ENST00000570565.1_Missense_Mutation_p.R11C|CA10_ENST00000285273.4_Missense_Mutation_p.R86C	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	86					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTGTTGATGCGAAGAGGTGTC	0.502000													68	203					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44260327	44260327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44260327G>A	ENST00000315087.7	-	7	1469	c.809C>T	c.(808-810)tCg>tTg	p.S270L	ST8SIA5_ENST00000538168.1_Missense_Mutation_p.S306L|ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000536490.1_Missense_Mutation_p.S239L	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	270					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						AGCTTGCGGCGATTCGAAGTC	0.622000													9	18					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606158	21606158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:21606158C>T	ENST00000281523.2	-	3	702	c.184G>A	c.(184-186)Gct>Act	p.A62T	ZNF385D-AS1_ENST00000412369.1_RNA|ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	62						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						TTTATTACAGCTTTCTGAATC	0.348000													26	66					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87656093	87656093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87656093C>T	ENST00000320005.5	-	10	1111	c.1064G>A	c.(1063-1065)cGa>cAa	p.R355Q		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	355					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						TCCAGTTGTTCGAATAACTCT	0.358000													30	63					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064305	9064305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9064305G>A	ENST00000397910.4	-	3	23344	c.23141C>T	c.(23140-23142)cCc>cTc	p.P7714L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7716	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACAGGAAGGGGAGAGGGGGG	0.537000													29	59					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175306769	175306769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175306769C>T	ENST00000367674.1	-	19	4137	c.3429G>A	c.(3427-3429)atG>atA	p.M1143I	TNR_ENST00000263525.2_Missense_Mutation_p.M1143I	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1143	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TGTCTCCATTCATCAAATGCT	0.507000													18	33					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2408075	2408075	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2408075G>A	ENST00000419816.2	+	1	322	c.48G>A	c.(46-48)gtG>gtA	p.V16V	PLCH2_ENST00000288766.5_5'UTR|PLCH2_ENST00000378488.3_Silent_p.V16V|PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000449969.1_Intron|PLCH2_ENST00000378486.3_Silent_p.V16V			O75038	PLCH2_HUMAN	phospholipase C, eta 2	16	Necessary for plasma membrane localization (By similarity).				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		AGGGAACGGTGGCCTGGCTGG	0.687000													7	10					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129691083	129691083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129691083G>A	ENST00000358303.4	-	1	208	c.124C>T	c.(124-126)Ccg>Tcg	p.P42S	ZC3HC1_ENST00000360708.5_Missense_Mutation_p.P42S|ZC3HC1_ENST00000311873.5_Silent_p.P5P|ZC3HC1_ENST00000481503.1_Missense_Mutation_p.P42S	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	42					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					CCCTCTTCCGGGGCAATCCCC	0.597000													42	84					0	0	1	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23444016	23444016	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23444016G>A	ENST00000526079.1	+	0	1660					NR_027407.1|NR_033350.1																						GGACACGGAGGAGAACATCTG	0.617000													10	65					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79579213	79579213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:79579213G>A	ENST00000372391.2	-	17	3542	c.3537C>T	c.(3535-3537)ccC>ccT	p.P1179P	DLG5_ENST00000372388.2_Silent_p.P839P|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1179					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TCAAACTCCGGGGAACAGTGC	0.612000													5	38					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116335236	116335236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116335236C>T	ENST00000533213.2	-	3	623	c.322G>A	c.(322-324)Gaa>Aaa	p.E108K	ABLIM1_ENST00000277895.5_Missense_Mutation_p.E168K|ABLIM1_ENST00000369252.4_Missense_Mutation_p.E108K			O14639	ABLM1_HUMAN	actin binding LIM protein 1	168	LIM zinc-binding 1.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding	p.E108K(1)		breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		GTCACCACTTCGCCCTCCACG	0.537000													27	82					0	0	1	0	0
NR2C1	7181	broad.mit.edu	37	12	95419008	95419008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95419008C>T	ENST00000333003.5	-	13	1885	c.1555G>A	c.(1555-1557)Gaa>Aaa	p.E519K		NM_003297.3	NP_003288.2	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	519					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)	13						TCTATCTGTTCCATGTTTTCT	0.343000													10	33					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101797320	101797320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101797320C>T	ENST00000375001.3	+	18	2527	c.2104C>T	c.(2104-2106)Cct>Tct	p.P702S		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	702	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CAGAGGCTTACCTGGACCCCC	0.612000													14	77					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66460536	66460536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:66460536C>T	ENST00000404260.3	+	29	5846	c.5538C>T	c.(5536-5538)ctC>ctT	p.L1846L	MAST4_ENST00000403625.2_Silent_p.L1843L|MAST4_ENST00000405643.1_Silent_p.L1664L|MAST4_ENST00000403666.1_Silent_p.L1654L|MAST4_ENST00000261569.7_Silent_p.L1649L			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1846						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CACCAGTTCTCCCCAGCAGCA	0.557000													21	53					0	0	1	0	0
CXCR4	7852	broad.mit.edu	37	2	136872763	136872763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136872763G>A	ENST00000409817.1	-	1	1050	c.747C>T	c.(745-747)atC>atT	p.I249I	CXCR4_ENST00000466288.1_5'UTR|CXCR4_ENST00000241393.3_Silent_p.I245I	NM_001008540.1	NP_001008540.1	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4	245					activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	AGAAAGCCAGGATGAGGATGA	0.502000													19	111					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51330320	51330320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51330320C>T	ENST00000326856.4	-	4	421	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	KLK15_ENST00000416184.1_Missense_Mutation_p.E99K|KLK15_ENST00000596931.1_Missense_Mutation_p.E98K|KLK15_ENST00000598239.1_Missense_Mutation_p.E99K|KLK15_ENST00000301421.2_Missense_Mutation_p.E99K	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	99	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CTGCGCGCTTCGTAGCGCGGG	0.667000													21	73					0	0	1	0	0
OR5V1	81696	broad.mit.edu	37	6	29323781	29323781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29323781C>T	ENST00000377154.1	-	4	491	c.192G>A	c.(190-192)ggG>ggA	p.G64G	OR5V1_ENST00000543825.1_Silent_p.G64G			Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V, member 1	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(3)|large_intestine(3)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AGGCCAAGTTCCCTAGAAAAT	0.408000													58	126					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73128174	73128174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:73128174G>A	ENST00000545377.1	+	10	1212	c.1036G>A	c.(1036-1038)Gat>Aat	p.D346N	ARHGEF28_ENST00000296794.6_Missense_Mutation_p.D346N|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.D33N|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.D346N|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.D346N|ARHGEF28_ENST00000426542.2_Missense_Mutation_p.D346N|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.D346N	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		TCGCTCCTTCGATATCCTAAA	0.423000													5	24					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173542416	173542416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173542416G>A	ENST00000367714.3	-	9	1373	c.951C>T	c.(949-951)ttC>ttT	p.F317F	SLC9C2_ENST00000466087.1_5'UTR|RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Silent_p.F215F	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	317					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										CAATGCCAAAGAAAGCATATA	0.284000													22	41					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109762861	109762861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:109762861G>A	ENST00000399132.1	-	31	2176	c.1646C>T	c.(1645-1647)cCt>cTt	p.P549L	COL25A1_ENST00000399126.1_Missense_Mutation_p.P549L|COL25A1_ENST00000399127.1_Missense_Mutation_p.P522L	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	549						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTTTGGTCCAGGAAGTCCATG	0.363000													20	36					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551337	35551337	+	Missense_Mutation	SNP	C	C	T	rs147075058	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35551337C>T	ENST00000262626.2	+	8	1366	c.541C>T	c.(541-543)Cgc>Tgc	p.R181C	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Intron|HPN_ENST00000392226.1_Missense_Mutation_p.R181C	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	181	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	AGTCAGCCTTCGCTATGATGG	0.682000													52	91					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176295654	176295654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176295654C>T	ENST00000329542.4	+	4	803	c.529C>T	c.(529-531)Cct>Tct	p.P177S	UNC5A_ENST00000261961.3_Missense_Mutation_p.P137S	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	177	Ig-like C2-type.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAGGGCATCCCTCCAGCCGA	0.667000													3	6					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186022189	186022189	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186022189T>A	ENST00000271588.4	+	43	6912	c.6683T>A	c.(6682-6684)cTc>cAc	p.L2228H	HMCN1_ENST00000367492.2_Missense_Mutation_p.L2228H	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2228	Ig-like C2-type 20.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCCCCAAATCTCATCTGGAAG	0.318000													48	75					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47514787	47514787	+	Missense_Mutation	SNP	G	G	A	rs149671949		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47514787G>A	ENST00000273859.3	+	2	499	c.230G>A	c.(229-231)cGa>cAa	p.R77Q	ATP10D_ENST00000504445.1_Missense_Mutation_p.R77Q	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	77					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						AATCGAATACGAACAACAAAG	0.388000													23	47					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130187704	130187704	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130187704C>T	ENST00000265379.6	+	38	7350	c.6856C>T	c.(6856-6858)Caa>Taa	p.Q2286*	COL6A5_ENST00000432398.2_Nonsense_Mutation_p.Q2286*			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2286	Nonhelical region.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						TGTCTCTCTTCAAGAATATTA	0.363000													10	23					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129498871	129498871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:129498871C>T	ENST00000421865.2	+	10	1376	c.1327C>T	c.(1327-1329)Cat>Tat	p.H443Y		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	443	Laminin EGF-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGGATCCTGTCATTGCAAAAC	0.443000													18	34					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35010173	35010173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35010173C>T	ENST00000231420.6	-	12	1470	c.1270G>A	c.(1270-1272)Gaa>Aaa	p.E424K		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	424					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	ATTTCAAATTCATCCCGCAGC	0.438000													49	100					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81381519	81381519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:81381519C>T	ENST00000222390.5	-	5	768	c.542G>A	c.(541-543)cGa>cAa	p.R181Q	HGF_ENST00000444829.2_Missense_Mutation_p.R181Q|HGF_ENST00000453411.1_Missense_Mutation_p.R176Q|HGF_ENST00000423064.2_Missense_Mutation_p.R181Q|HGF_ENST00000457544.2_Missense_Mutation_p.R176Q	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	181	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TTCTTCCCCTCGAGGATTTCG	0.433000													20	93					0	0	1	0	0
FAM117B	150864	broad.mit.edu	37	2	203621974	203621974	+	Silent	SNP	C	C	T	rs140222767		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:203621974C>T	ENST00000303116.6	+	6	1153	c.411C>T	c.(409-411)ccC>ccT	p.P137P	FAM117B_ENST00000392238.2_Silent_p.P381P	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	381	Poly-Pro.									breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						CTCCACCCCCCCTTGTACAGA	0.493000													18	45					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127623022	127623022	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127623022C>T	ENST00000508053.1	-	60	7832	c.6858G>A	c.(6856-6858)agG>agA	p.R2286R	FBN2_ENST00000262464.4_Silent_p.R2286R			P35556	FBN2_HUMAN	fibrillin 2	2286	EGF-like 38; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTTGATCTTCCCTGAGGGCAT	0.453000													42	132					0	0	1	0	0
LOXL1	4016	broad.mit.edu	37	15	74238812	74238812	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74238812C>T	ENST00000261921.7	+	3	1592	c.1266C>T	c.(1264-1266)ttC>ttT	p.F422F		NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	422	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						TACTGCGCTTCCCCCAGCGCG	0.677000													9	46					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68910518	68910518	+	Silent	SNP	G	G	A	rs62642583		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:68910518G>A	ENST00000262340.5	-	4	347	c.294C>T	c.(292-294)atC>atT	p.I98I		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	98					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						CTGTTATGACGATCCTTTTCT	0.423000													23	53					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33591242	33591242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33591242C>T	ENST00000380099.3	+	1	672	c.664C>T	c.(664-666)Ctc>Ttc	p.L222F	KL_ENST00000426690.2_Intron|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	222	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTACGCGGAGCTCTGCTTCCG	0.692000													4	32					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34174758	34174758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34174758C>T	ENST00000373381.4	-	22	3683	c.3507G>A	c.(3505-3507)caG>caA	p.Q1169Q	CSMD2_ENST00000373380.1_Silent_p.Q42Q|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1129	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTGGCTGGGTCTGGATGGAGT	0.473000													31	81					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48353039	48353039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:48353039C>T	ENST00000297423.4	+	8	1416	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F	SPIDR_ENST00000541342.1_Silent_p.F274F|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000518074.1_Silent_p.F284F	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		AAGTTCTCTTCACCAAGGAGA	0.587000													23	56					0	0	1	0	0
IL12B	3593	broad.mit.edu	37	5	158750330	158750330	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:158750330G>A	ENST00000231228.2	-	3	551	c.96C>T	c.(94-96)gtC>gtT	p.V32V		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	32	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAATTCTACGACATAAACTG	0.498000													15	37					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045373	142045373	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142045373G>A	ENST00000390392.3	+	0	122																											ATGGGCTGCAGGCTGCTCTGC	0.567000													20	163					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107078653	107078653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107078653C>T	ENST00000229387.5	+	1	180	c.62C>T	c.(61-63)tCg>tTg	p.S21L	RFX4_ENST00000357881.4_Intron|RFX4_ENST00000392842.1_Intron|RP11-144F15.1_ENST00000551505.1_Intron	NM_032491.5	NP_115880.2	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	369					transcription, DNA-dependent	nucleus	DNA binding	p.S21L(1)		NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						cagatagattcgagatgccca	0.478000													8	4					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141459834	141459834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141459834G>A	ENST00000389484.3	-	39	7149	c.6178C>T	c.(6178-6180)Cgc>Tgc	p.R2060C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2060					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGTCTGTGCGAGCATCACAC	0.373000										TSP Lung(27;0.18)			13	166					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166900351	166900351	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166900351T>A	ENST00000423058.2	-	11	1888	c.1871A>T	c.(1870-1872)cAg>cTg	p.Q624L	SCN1A_ENST00000409050.1_Missense_Mutation_p.Q624L|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.Q624L|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.Q624L	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	624						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCTACTGGTCTGACTCAGGTT	0.537000													19	70					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153585856	153585856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153585856G>A	ENST00000422373.1	-	29	5139	c.4891C>T	c.(4891-4893)Ccg>Tcg	p.P1631S	FLNA_ENST00000369850.3_Missense_Mutation_p.P1631S|FLNA_ENST00000344736.4_Missense_Mutation_p.P1631S|FLNA_ENST00000360319.4_Missense_Mutation_p.P1631S|FLNA_ENST00000369856.3_5'UTR	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1631					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACGCGGTACGGGGAGAAGGGG	0.652000													14	12					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7334968	7334968	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7334968C>T	ENST00000318881.6	+	3	1077	c.840C>T	c.(838-840)acC>acT	p.T280T	SYT9_ENST00000396716.2_Silent_p.T248T	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	280	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		ACAGAAAGACCCTGAACCCTG	0.438000													27	278					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013108	107013108	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107013108C>T	ENST00000390625.2	-	0	266																											CACTCCAGCCCCTTCCCTGGA	0.522000													25	110					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36301496	36301496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36301496C>T	ENST00000296604.3	-	1	508	c.23G>A	c.(22-24)gGc>gAc	p.G8D	RANBP3L_ENST00000502994.1_Missense_Mutation_p.G8D|RANBP3L_ENST00000515759.1_Missense_Mutation_p.G8D	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	8					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GTGGCTGCTGCCTTTTCTTGG	0.542000													24	111					0	0	1	0	0
ZNF527	84503	broad.mit.edu	37	19	37879797	37879797	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37879797C>T	ENST00000436120.2	+	5	953	c.846C>T	c.(844-846)gcC>gcT	p.A282A	ZNF527_ENST00000587349.1_Intron	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTGGTGATGCCTTTAGCTGTT	0.383000													45	134					0	0	1	0	0
PPA2	27068	broad.mit.edu	37	4	106345444	106345444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:106345444G>A	ENST00000341695.5	-	7	594	c.564C>T	c.(562-564)atC>atT	p.I188I	PPA2_ENST00000380004.2_Silent_p.I170I|PPA2_ENST00000354147.3_Intron|PPA2_ENST00000310267.7_Silent_p.I109I|PPA2_ENST00000509426.1_5'UTR|PPA2_ENST00000357415.4_Silent_p.I203I|PPA2_ENST00000348706.5_Silent_p.I159I|PPA2_ENST00000432483.2_Silent_p.I86I	NM_176869.2	NP_789845.1	Q9H2U2	IPYR2_HUMAN	pyrophosphatase (inorganic) 2	188					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	11		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)		AAATTCCAAGGATCTTCACAT	0.338000													35	83					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31590856	31590856	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31590856C>T	ENST00000379416.3	-	20	2216	c.2168G>A	c.(2167-2169)gGg>gAg	p.G723E		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	723					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TTCGGAAAACCCCTTCTTTAG	0.448000													48	159					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231150513	231150513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231150513G>A	ENST00000392045.3	+	17	1725	c.1611G>A	c.(1609-1611)gcG>gcA	p.A537A	SP140_ENST00000417495.3_Silent_p.A423A|SP140_ENST00000486687.2_Silent_p.A461A|SP140_ENST00000420434.3_Silent_p.A510A|SP140_ENST00000350136.5_Silent_p.A406A|SP140_ENST00000343805.6_Silent_p.A477A	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	537					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AAAAGAAGGCGAACGTGAATC	0.443000													17	179					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58084602	58084602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58084602C>T	ENST00000357272.4	+	8	1477	c.1312C>T	c.(1312-1314)Cct>Tct	p.P438S	FLNB_ENST00000493452.1_Missense_Mutation_p.P269S|FLNB_ENST00000490882.1_Missense_Mutation_p.P438S|FLNB_ENST00000429972.2_Missense_Mutation_p.P438S|FLNB_ENST00000419752.2_Missense_Mutation_p.P269S|FLNB_ENST00000348383.5_Missense_Mutation_p.P438S|FLNB_ENST00000295956.4_Missense_Mutation_p.P438S|FLNB_ENST00000358537.3_Missense_Mutation_p.P438S			O75369	FLNB_HUMAN	filamin B, beta	438					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGACACTATTCCTAAGAGTCC	0.552000													25	94					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3679990	3679990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3679990C>T	ENST00000344754.4	-	7	1644	c.1645G>A	c.(1645-1647)Gga>Aga	p.G549R	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.G549R	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	549	Ig-like C2-type 5.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						AGCAGGGCTCCATTCAGGTAC	0.687000													5	16					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129198739	129198739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129198739C>T	ENST00000296266.3	+	14	1807	c.1615C>T	c.(1615-1617)Ctc>Ttc	p.L539F	IFT122_ENST00000440957.2_Missense_Mutation_p.L279F|IFT122_ENST00000431818.2_Missense_Mutation_p.L338F|IFT122_ENST00000504021.1_Missense_Mutation_p.L382F|IFT122_ENST00000349441.2_Missense_Mutation_p.L377F|IFT122_ENST00000347300.2_Missense_Mutation_p.L429F|IFT122_ENST00000507564.1_Missense_Mutation_p.L480F|IFT122_ENST00000348417.2_Missense_Mutation_p.L488F	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	488					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						AAGAGAAGGCCTCTTAGTGGG	0.562000													27	60					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113815359	113815359	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113815359C>T	ENST00000260191.2	+	8	1229	c.972C>T	c.(970-972)gtC>gtT	p.V324V	HTR3B_ENST00000537778.1_Silent_p.V313V	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	324					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TCGTGTTGGTCAAATTCCTCC	0.562000													10	83					0	0	1	0	0
CLLU1OS	574016	broad.mit.edu	37	12	92814813	92814813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:92814813C>T	ENST00000378487.2	-	3	280	c.279G>A	c.(277-279)ggG>ggA	p.G93G	CLLU1OS_ENST00000538965.1_Silent_p.G93G	NM_001025232.1	NP_001020403.1	Q5K130	CLU1O_HUMAN	chronic lymphocytic leukemia up-regulated 1 opposite strand	93										large_intestine(1)|lung(7)	8						CTTCCTTCTTCCCATCATCAT	0.428000													79	347					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1743171	1743171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1743171G>A	ENST00000381241.3	+	3	453	c.254G>A	c.(253-255)cGa>cAa	p.R85Q	ASMT_ENST00000381233.3_Missense_Mutation_p.R85Q|ASMT_ENST00000381229.4_Missense_Mutation_p.R85Q	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	85					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCTTTCTATCGAAACACAGAG	0.547000													76	194					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165179979	165179979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165179979C>T	ENST00000342310.3	-	6	1086	c.704G>A	c.(703-705)aGt>aAt	p.S235N	LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Missense_Mutation_p.S235N|LMX1A_ENST00000367893.4_Missense_Mutation_p.S235N|RP11-38C18.2_ENST00000457106.1_RNA	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	235						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					GACACGGACACTCAGCCCTGT	0.483000													7	44					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41450713	41450713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41450713G>A	ENST00000400454.1	-	26	5089	c.4612C>T	c.(4612-4614)Ctg>Ttg	p.L1538L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1538	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCTTCCTGCAGGTCATACAGG	0.577000													14	37					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7173261	7173261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7173261C>T	ENST00000406697.1	+	10	1486	c.858C>T	c.(856-858)cgC>cgT	p.R286R	C1S_ENST00000328916.3_Silent_p.R286R|C1S_ENST00000402681.3_Silent_p.R119R|C1S_ENST00000360817.5_Silent_p.R286R			P09871	C1S_HUMAN	complement component 1, s subcomponent	286	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GGAAACTTCGCTATCATGGAG	0.433000													6	78					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38229537	38229537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38229537G>A	ENST00000339503.4	-	8	2181	c.1680C>T	c.(1678-1680)gcC>gcT	p.A560A	ZNF573_ENST00000590414.2_Silent_p.A618A|ZNF573_ENST00000536220.1_Silent_p.A530A|ZNF573_ENST00000392138.1_Silent_p.A531A|ZNF573_ENST00000357309.3_Silent_p.A530A	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			CACGACTGAAGGCCTTCCCAC	0.403000													22	102					0	0	1	0	0
ZDHHC1	29800	broad.mit.edu	37	16	67429105	67429105	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67429105G>A	ENST00000348579.2	-	10	1371	c.1030C>T	c.(1030-1032)Ccg>Tcg	p.P344S	ZDHHC1_ENST00000566075.1_5'UTR	NM_013304.2	NP_037436.1	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	344						integral to membrane	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|urinary_tract(1)	10		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		GTCGGATCCGGGGAGGCAGGG	0.637000													10	13					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126208199	126208199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126208199C>T	ENST00000290868.2	-	17	1681	c.1628G>A	c.(1627-1629)cGa>cAa	p.R543Q	UROC1_ENST00000383579.3_Missense_Mutation_p.R603Q	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	543					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		ATGGTGATCTCGGCTCAGGAC	0.577000													21	100					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50155850	50155850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50155850C>T	ENST00000347869.3	+	25	2584	c.2409C>T	c.(2407-2409)gtC>gtT	p.V803V	RP11-493K19.3_ENST00000425674.1_RNA|RP11-493K19.3_ENST00000437204.1_RNA	NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	803	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AAGATGCTGTCCGGAAAGCCA	0.542000													6	41					0	0	1	0	0
CCT5	22948	broad.mit.edu	37	5	10261701	10261701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:10261701C>T	ENST00000280326.4	+	8	1443	c.1023C>T	c.(1021-1023)atC>atT	p.I341I	CCT5_ENST00000506600.1_Silent_p.I248I|CCT5_ENST00000503026.1_Silent_p.I320I|CCT5_ENST00000515676.1_Silent_p.I303I|CCT5_ENST00000515390.1_Silent_p.I286I	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	341					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						GAGGGCGGATCGTCCCCAGGT	0.502000													95	296					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27745364	27745364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27745364G>A	ENST00000264717.2	+	18	1673	c.1610G>A	c.(1609-1611)aGc>aAc	p.S537N	GCKR_ENST00000424318.2_Missense_Mutation_p.S347N	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	537					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					TGCATCGAGAGCCTCCTCCGA	0.527000													23	85					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96239829	96239829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:96239829C>T	ENST00000347108.3	-	18	2614	c.2182G>A	c.(2182-2184)Gaa>Aaa	p.E728K	DZIP1_ENST00000361396.2_Missense_Mutation_p.E709K|DZIP1_ENST00000376829.2_Missense_Mutation_p.E728K|DZIP1_ENST00000361156.3_Missense_Mutation_p.E709K			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	728					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TCCTCGATTTCGCTTCCCTCG	0.547000													39	98					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4945091	4945091	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4945091G>A	ENST00000321961.2	-	1	546	c.479C>T	c.(478-480)cCc>cTc	p.P160L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAATGGCAAGGGGAGGATGAG	0.542000													19	46					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37433933	37433933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37433933C>T	ENST00000374660.1	+	8	1335	c.1236C>T	c.(1234-1236)ttC>ttT	p.F412F	ANKRD30A_ENST00000361713.1_Silent_p.F412F|ANKRD30A_ENST00000602533.1_Silent_p.F412F			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	468						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATCAGAGGTTCCCATCAGAAT	0.254000													45	89					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17104307	17104307	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17104307G>A	ENST00000443236.1	-	12	1357	c.1326C>T	c.(1324-1326)acC>acT	p.T442T	CPAMD8_ENST00000388925.4_Silent_p.T395T	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	395						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CAACTTCACTGGTGTAGATGT	0.577000													12	46					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54893190	54893190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54893190G>A	ENST00000293373.6	+	2	233	c.154G>A	c.(154-156)Gaa>Aaa	p.E52K	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E2K	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	52					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						AAAGTCCATGGAACCATCTCT	0.418000													42	91					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54802530	54802530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54802530G>A	ENST00000391745.1	-	9	1278	c.962C>T	c.(961-963)tCc>tTc	p.S321F	LILRA3_ENST00000391744.3_Missense_Mutation_p.S240F|LILRA3_ENST00000251390.3_Missense_Mutation_p.S304F					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCACTCGGAGGAGAGGTTGTA	0.677000													27	74					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69699681	69699681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:69699681G>A	ENST00000337103.4	+	11	2718	c.1126G>A	c.(1126-1128)Gaa>Aaa	p.E376K	C8orf34_ENST00000539993.1_Missense_Mutation_p.E401K|C8orf34_ENST00000518698.1_Missense_Mutation_p.E487K|C8orf34_ENST00000325233.3_Missense_Mutation_p.E145K			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	401					signal transduction		cAMP-dependent protein kinase regulator activity	p.E376K(1)		NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TTTGCAGGATGAATCCTTAAA	0.358000													6	25					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58606038	58606038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:58606038G>A	ENST00000267485.7	-	2	233	c.39C>T	c.(37-39)ttC>ttT	p.F13F	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	13						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						GAAGGCTACAGAAAGCCAGAC	0.473000													39	68					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33603471	33603471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33603471C>T	ENST00000170564.2	+	13	2158	c.1844C>T	c.(1843-1845)cCt>cTt	p.P615L		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	615						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					GAGTGGCACCCTGACAAGCTT	0.413000													28	58					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103143606	103143606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103143606G>A	ENST00000428762.1	-	52	8505	c.8346C>T	c.(8344-8346)ttC>ttT	p.F2782F	RELN_ENST00000424685.2_Silent_p.F2782F|RELN_ENST00000343529.5_Silent_p.F2782F|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2782					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.F2782L(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AACTCACACCGAAGTCAGTAG	0.408000													35	73					0	0	1	0	0
FAM83H	286077	broad.mit.edu	37	8	144810193	144810193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144810193G>A	ENST00000388913.3	-	5	1563	c.1438C>T	c.(1438-1440)Cgc>Tgc	p.R480C		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	480					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAACCCGCGCGGCCCCCGCGA	0.721000													5	8					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32476018	32476018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:32476018G>A	ENST00000404025.2	-	5	1403	c.915C>T	c.(913-915)gcC>gcT	p.A305A	NLRC4_ENST00000360906.5_Silent_p.A305A|NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Silent_p.A305A			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	305	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TGAGAGCCTGGGCGCTGTCTT	0.532000													34	77					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120539917	120539917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120539917G>A	ENST00000256646.2	-	4	673	c.454C>T	c.(454-456)Ccc>Tcc	p.P152S	NOTCH2_ENST00000602566.1_Missense_Mutation_p.P113S	NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	152	EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTGCACAGGGATGAGACAGG	0.498000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				33	131					0	0	1	0	0
IL36G	56300	broad.mit.edu	37	2	113736250	113736250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113736250G>A	ENST00000259205.4	+	2	104	c.35G>A	c.(34-36)gGa>gAa	p.G12E	IL36G_ENST00000376489.2_Missense_Mutation_p.G12E	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	12					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						GATGGTGGAGGAAGGGCCGTC	0.527000													23	52					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29886152	29886152	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29886152G>A	ENST00000310624.6	+	4	2556	c.2523G>A	c.(2521-2523)aaG>aaA	p.K841K		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	847	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						CCCCAAAGAAGGCAGAGGAAG	0.547000													4	28					0	0	1	0	0
ABHD14B	84836	broad.mit.edu	37	3	52003882	52003882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52003882C>T	ENST00000461108.1	-	3	614	c.530G>A	c.(529-531)gGg>gAg	p.G177E	ABHD14B_ENST00000361143.5_Intron|ABHD14B_ENST00000395008.2_Intron|ABHD14B_ENST00000525795.1_Intron|ABHD14B_ENST00000483233.1_Intron|RP11-155D18.12_ENST00000488257.1_RNA|ABHD14B_ENST00000487005.1_Intron|ABHD14B_ENST00000315877.10_Intron			Q96IU4	ABHEB_HUMAN	abhydrolase domain containing 14B	0						cytoplasm|nucleus	hydrolase activity			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000548)|KIRC - Kidney renal clear cell carcinoma(197;0.00072)		ATTATCCAGCCCCCAGATGAG	0.567000													7	38					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122759917	122759917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:122759917G>A	ENST00000245838.8	-	25	2934	c.2903C>T	c.(2902-2904)tCt>tTt	p.S968F	THOC2_ENST00000355725.4_Missense_Mutation_p.S968F|THOC2_ENST00000491737.1_Missense_Mutation_p.S853F	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	968					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						ATTTTTGGTAGATTCTAAAAA	0.333000													12	10					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139727966	139727966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139727966C>T	ENST00000303045.6	-	30	2922	c.2476G>A	c.(2476-2478)Gaa>Aaa	p.E826K	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Missense_Mutation_p.E826K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	826	Collagen-like 6.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AGTCCCAGTTCACCTTTTTCT	0.388000										HNSCC(7;0.00092)			29	107					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8234487	8234487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8234487G>A	ENST00000520004.1	-	3	1696	c.1432C>T	c.(1432-1434)Cac>Tac	p.H478Y	SGK223_ENST00000330777.4_Missense_Mutation_p.H478Y			Q86YV5	SG223_HUMAN		478							ATP binding|non-membrane spanning protein tyrosine kinase activity										TCTTCCGGGTGGGCCGCCATG	0.647000													7	32					0	0	1	0	0
RNF219	79596	broad.mit.edu	37	13	79190701	79190701	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:79190701G>A	ENST00000282003.6	-	6	1253	c.1195C>T	c.(1195-1197)Cag>Tag	p.Q399*	RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000606429.1_RNA	NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	399							zinc ion binding	p.Q399E(1)		breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GTACTGAGCTGAAGGCAACTA	0.423000													43	132					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109155434	109155434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:109155434G>A	ENST00000261483.4	+	14	3226	c.2174G>A	c.(2173-2175)aGt>aAt	p.S725N		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	725					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		GAATCAGCAAGTTCAAATTCA	0.308000													25	131					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128341841	128341841	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128341841G>A	ENST00000389524.4	+	13	1541	c.1488G>A	c.(1486-1488)ctG>ctA	p.L496L	MYO7B_ENST00000428314.1_Silent_p.L496L|MYO7B_ENST00000409816.2_Silent_p.L496L			Q6PIF6	MYO7B_HUMAN	myosin VIIB	496	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGCCCACCCTGGACCTGCTGG	0.587000													16	60					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38793807	38793807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38793807G>A	ENST00000449082.2	-	11	1657	c.1658C>T	c.(1657-1659)cCt>cTt	p.P553L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	553					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTGAGGAAGAGGGCTTCTAGG	0.612000													37	71					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748223	143748223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143748223C>T	ENST00000408906.2	+	1	763	c.729C>T	c.(727-729)tcC>tcT	p.S243S		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CCTGCTCCTCCCACCTTTGCA	0.617000													14	179					0	0	1	0	0
TRAM1	23471	broad.mit.edu	37	8	71499399	71499399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:71499399G>A	ENST00000521425.1	-	7	1361	c.325C>T	c.(325-327)Cgt>Tgt	p.R109C	TRAM1_ENST00000521049.1_5'UTR|TRAM1_ENST00000262213.2_Missense_Mutation_p.R195C|TRAM1_ENST00000536748.1_Missense_Mutation_p.R164C			Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	195					cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	17			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			ACAAGCTGACGAGGAATATCT	0.398000													20	54					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917308	48917308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48917308C>T	ENST00000311378.4	+	2	1187	c.659C>T	c.(658-660)tCg>tTg	p.S220L	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.S127L	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	220	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GTGCACCAGTCGGTCACCATG	0.637000													14	48					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106843718	106843718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:106843718C>T	ENST00000276185.4	+	16	2548	c.2548C>T	c.(2548-2550)Cgg>Tgg	p.R850W				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	850						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						CCTGCCCTTCCGGATCCAGAG	0.612000													25	15					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66189691	66189691	+	Silent	SNP	G	G	A	rs147825645	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66189691G>A	ENST00000311034.2	+	2	452	c.276G>A	c.(274-276)ggG>ggA	p.G92G		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	92	PAS 1.				transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CAGCCGAGGGGAAATTGCTCT	0.602000													29	80					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74285296	74285296	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74285296C>T	ENST00000295897.4	+	13	1814	c.1725C>T	c.(1723-1725)ttC>ttT	p.F575F	ALB_ENST00000415165.2_Silent_p.F383F|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000401494.3_Silent_p.F460F|ALB_ENST00000509063.1_Silent_p.F575F|ALB_ENST00000503124.1_Silent_p.F425F	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	575	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TGGATGATTTCGCAGCTTTTG	0.413000													29	75					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119097170	119097170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119097170C>T	ENST00000328252.3	+	13	3797	c.3428C>T	c.(3427-3429)cCc>cTc	p.P1143L	PAPPA_ENST00000534838.1_Missense_Mutation_p.P181L	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1143					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						AGGAACAATCCCCTGATTATC	0.632000													12	52					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2153339	2153339	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2153339C>A	ENST00000262304.4	-	23	8927	c.8719G>T	c.(8719-8721)Gct>Tct	p.A2907S	PKD1_ENST00000423118.1_Missense_Mutation_p.A2907S	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	2907					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GTGACCACAGCACCGACGGAG	0.692000													15	91					1.2644e-06	1.26736e-06	1	1	0
MYO16	23026	broad.mit.edu	37	13	109817360	109817360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109817360C>T	ENST00000356711.2	+	33	5336	c.5210C>T	c.(5209-5211)tCa>tTa	p.S1737L	MYO16_ENST00000357550.2_Missense_Mutation_p.S1737L|MYO16-AS1_ENST00000439299.1_RNA	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1737					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTATCTAATTCACTATCTAGT	0.348000													14	32					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118779085	118779085	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118779085G>A	ENST00000334801.3	-	2	1270	c.306C>T	c.(304-306)ccC>ccT	p.P102P	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	102					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		AGCTGAAAGGGGGCACCCCTG	0.637000													32	79					0	0	1	0	0
XCR1	2829	broad.mit.edu	37	3	46062951	46062951	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46062951G>A	ENST00000309285.3	-	2	845	c.489C>T	c.(487-489)ctC>ctT	p.L163L	XCR1_ENST00000542109.1_Silent_p.L163L	NM_001024644.1	NP_001019815.1	P46094	XCR1_HUMAN	chemokine (C motif) receptor 1	163					chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		AGATGGTGTCGAGGATGGAGG	0.602000													10	19					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23235899	23235899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23235899C>T	ENST00000285848.5	+	1	169	c.169C>T	c.(169-171)Ctt>Ttt	p.L57F	OXA1L_ENST00000604262.1_5'UTR	NM_005015.3	NP_005006.3	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	0					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		AGCAAGTCCTCTTCCGGGCAA	0.607000													57	128					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37584296	37584296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37584296C>T	ENST00000399151.3	+	7	890	c.805C>T	c.(805-807)Ctc>Ttc	p.L269F	DOPEY2_ENST00000492760.1_3'UTR	NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	269					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						AGCCATCCCCCTCCTCAGATC	0.502000													25	85					0	0	1	0	0
FGF21	26291	broad.mit.edu	37	19	49261309	49261309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49261309G>A	ENST00000593756.1	+	4	1034	c.462G>A	c.(460-462)cgG>cgA	p.R154R	FGF21_ENST00000222157.3_Silent_p.R154R			Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21	154					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)|cervix(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		CCCCACACCGGGACCCTGCAC	0.682000													36	56					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31915571	31915571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31915571C>T	ENST00000456570.1	+	17	2272	c.2217C>T	c.(2215-2217)tcC>tcT	p.S739S	CFB_ENST00000425368.2_Silent_p.S237S|CFB_ENST00000477310.1_Silent_p.S588S|CFB_ENST00000556679.1_Silent_p.S739S			P00751	CFAB_HUMAN	complement factor B	237	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TCCTGTCTTCCCTGACAGAGA	0.547000													87	184					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31127291	31127291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31127291C>T	ENST00000304166.4	+	12	1224	c.935C>T	c.(934-936)cCt>cTt	p.P312L	ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.P291L|ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.P312L|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.P312L	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	312					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity	p.P312N(1)		endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						ATCAAAGGCCCTGTGGTTGGC	0.517000													24	64					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147540	26147540	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:26147540C>T	ENST00000331351.5	+	2	1734	c.1342C>T	c.(1342-1344)Cag>Tag	p.Q448*		NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	448					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		TCAAGATTTTCAGTGGGAACA	0.468000													5	14					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190195323	190195323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190195323G>A	ENST00000367462.3	-	6	1081	c.850C>T	c.(850-852)Ccc>Tcc	p.P284S	FAM5C_ENST00000534846.1_Missense_Mutation_p.P182S|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		284						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGAAATTTGGGACCACAGTGA	0.438000													20	61					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33505192	33505192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33505192G>A	ENST00000404816.2	+	19	3432	c.3079G>A	c.(3079-3081)Gaa>Aaa	p.E1027K	LTBP1_ENST00000404525.1_Missense_Mutation_p.E648K|LTBP1_ENST00000402934.1_Missense_Mutation_p.E648K|LTBP1_ENST00000390003.4_Missense_Mutation_p.E702K|LTBP1_ENST00000418533.2_Missense_Mutation_p.E701K|LTBP1_ENST00000407925.1_Missense_Mutation_p.E701K|LTBP1_ENST00000354476.3_Missense_Mutation_p.E1028K			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1027	EGF-like 7; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCCCTGCACAGAAGGATTCCG	0.423000													15	82					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374541	8374541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8374541G>A	ENST00000538603.1	-	7	1830	c.1272C>T	c.(1270-1272)ctC>ctT	p.L424L	FAM90A1_ENST00000307435.6_Silent_p.L424L	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	424							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		GGCTCTGAGCGAGGAAGGCTC	0.592000													10	41					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42295569	42295569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:42295569G>A	ENST00000379310.3	-	25	2969	c.2901C>T	c.(2899-2901)gaC>gaT	p.D967D	VWA8_ENST00000281496.6_Silent_p.D967D	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		TAATCCCTTGGTCAGCCAAAC	0.473000													43	117					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70890760	70890760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70890760C>T	ENST00000264436.3	-	16	2422	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K	ADD2_ENST00000407644.2_Missense_Mutation_p.E660K|ADD2_ENST00000355733.3_3'UTR	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	660					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CTGAGGATTTCCTCTGCCGTC	0.577000													56	99					0	0	1	0	0
PDGFB	5155	broad.mit.edu	37	22	39631795	39631795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39631795C>T	ENST00000331163.6	-	2	935	c.148G>A	c.(148-150)Gga>Aga	p.G50R	PDGFB_ENST00000381551.4_Missense_Mutation_p.G35R	NM_002608.2	NP_002599.1	P01127	PDGFB_HUMAN	platelet-derived growth factor beta polypeptide	50					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(429)	central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Melanoma(58;0.04)				Becaplermin(DB00102)	CCGGGGTCTCCGTGCAGCAGG	0.617000			T	COL1A1	DFSP								8	23					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7340403	7340403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:7340403C>T	ENST00000486284.1	+	3	1043	c.769C>T	c.(769-771)Ccc>Tcc	p.P257S	GRM7_ENST00000403881.1_Missense_Mutation_p.P257S|GRM7_ENST00000389336.4_Missense_Mutation_p.P257S|GRM7_ENST00000402647.2_Missense_Mutation_p.P257S|GRM7_ENST00000357716.4_Missense_Mutation_p.P257S	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	257					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CGTGAGAATCCCCCAGGAACG	0.473000													33	63					0	0	1	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198420	91198420	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:91198420G>A	ENST00000341233.4	-	6	1269	c.879C>T	c.(877-879)tcC>tcT	p.S293S	SLC16A12_ENST00000371790.4_Silent_p.S323S	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	293						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						CTCCAAGTATGGACATAAGAA	0.443000													22	98					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1251138	1251138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1251138G>A	ENST00000308624.5	+	12	1057	c.928G>A	c.(928-930)Gct>Act	p.A310T	SNTG2_ENST00000407292.1_Missense_Mutation_p.A183T	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	310	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		ACTCCAAGGAGCTGACTCCTC	0.498000													13	34					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228505603	228505603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228505603G>A	ENST00000570156.2	+	64	16805	c.16731G>A	c.(16729-16731)ccG>ccA	p.P5577P	OBSCN_ENST00000366707.4_Silent_p.P2254P|OBSCN_ENST00000422127.1_Silent_p.P4620P|OBSCN_ENST00000284548.11_Silent_p.P4620P|OBSCN_ENST00000366709.4_Silent_p.P1739P	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4620					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding	p.P5202P(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGAGCCACCGAAGCCTGTGC	0.667000													3	11					0	0	1	0	0
DCUN1D3	123879	broad.mit.edu	37	16	20871407	20871407	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20871407G>A	ENST00000324344.3	-	3	1001	c.716C>T	c.(715-717)tCc>tTc	p.S239F	DCUN1D3_ENST00000563934.1_Missense_Mutation_p.S239F|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3	239	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		AGTGTCCCGGGAGATGCCCTT	0.507000													22	101					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46308052	46308052	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46308052C>T	ENST00000221538.3	-	3	1253	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	RSPH6A_ENST00000597055.1_Missense_Mutation_p.E371K|RSPH6A_ENST00000600188.1_Missense_Mutation_p.E107K	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	371	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						acctcctcctcctctgcctcc	0.652000													7	22					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101510519	101510519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101510519G>A	ENST00000392979.3	+	24	2769	c.2408G>A	c.(2407-2409)cGa>cAa	p.R803Q	ANO4_ENST00000392977.3_Missense_Mutation_p.R838Q|ANO4_ENST00000550015.1_Missense_Mutation_p.R358Q|ANO4_ENST00000299222.9_Missense_Mutation_p.R358Q	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	838						chloride channel complex	chloride channel activity	p.R803Q(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TTTGAGAACCGATCTGAGCCT	0.507000										HNSCC(74;0.22)			62	139					0	0	1	0	0
AKR1B15	441282	broad.mit.edu	37	7	134256405	134256405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:134256405G>A	ENST00000457545.2	+	6	745	c.485G>A	c.(484-486)gGa>gAa	p.G162E	AKR1B15_ENST00000423958.1_Missense_Mutation_p.G134E	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	162							oxidoreductase activity	p.G134V(1)|p.G134E(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						ATGATCAGTGGAAAAGGAACG	0.418000													26	126					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88367436	88367436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:88367436G>A	ENST00000419482.2	+	1	138	c.53G>A	c.(52-54)gGa>gAa	p.G18E	SMYD1_ENST00000444564.2_Missense_Mutation_p.G18E|SMYD1_ENST00000438570.1_Missense_Mutation_p.G18E	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	18					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						GAGGGCAAAGGAAGGGGTCTG	0.522000													68	147					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58639509	58639509	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58639509C>T	ENST00000358781.2	-	3	324		c.e3-1			NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D						negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CGAAGCACACCTGCTGAGCAA	0.532000													8	71					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30034149	30034149	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30034149C>T	ENST00000328224.6	-	2	1310	c.77G>A	c.(76-78)cGg>cAg	p.R26Q		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	26						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CTCCCGGGCCCGGGCCTGGGC	0.627000													27	132					0	0	1	0	0
CSH1	1442	broad.mit.edu	37	17	61972690	61972690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61972690G>A	ENST00000329882.8	-	4	669	c.599C>T	c.(598-600)cCt>cTt	p.P200L	CSH1_ENST00000453363.3_Intron|CSH1_ENST00000316193.8_Intron			P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 (placental lactogen)	0					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			central_nervous_system(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						AAGGCCTGGAGGATTCACCAG	0.527000									Russell-Silver syndrome				52	117					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28618371	28618371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28618371C>T	ENST00000395609.1	-	7	1158	c.400G>A	c.(400-402)Gat>Aat	p.D134N	SULT1A1_ENST00000350842.4_Missense_Mutation_p.D56N|SULT1A1_ENST00000395607.1_Missense_Mutation_p.D134N|SULT1A1_ENST00000569554.1_Missense_Mutation_p.D134N|SULT1A1_ENST00000314752.7_Missense_Mutation_p.D134N			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	134					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						ACTGCCACATCCTTTGCGTTG	0.572000													20	90					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169108797	169108797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169108797G>A	ENST00000256935.8	+	7	600	c.520G>A	c.(520-522)Gac>Aac	p.D174N		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	174					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAATATCTTGGACCCTGATAA	0.403000													45	144					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	488989	488989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:488989C>T	ENST00000230449.4	-	27	2806	c.2671G>A	c.(2671-2673)Gca>Aca	p.A891T	EXOC2_ENST00000448181.3_Missense_Mutation_p.A486T	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	891					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TTTTTATCTGCTCCACTGGAA	0.428000													76	174					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61868589	61868589	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61868589C>T	ENST00000280772.1	-	27	3363	c.3173_splice	c.e27+1	p.G1058_splice	ANK3_ENST00000355288.2_Splice_Site_p.G192_splice|ANK3_ENST00000503366.1_Splice_Site_p.G1059_splice|ANK3_ENST00000373827.2_Splice_Site_p.G1052_splice	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1058	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACAACTTACCCTAAAAATTGT	0.438000													8	51					0	0	1	0	0
C6orf15	29113	broad.mit.edu	37	6	31079766	31079766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31079766C>T	ENST00000259870.3	-	2	373	c.370G>A	c.(370-372)Gag>Aag	p.E124K		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	124								p.E124*(1)		endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						AGGCGGTCCTCAGCCGCAGCA	0.652000													13	60					0	0	1	0	0
PPP1R18	170954	broad.mit.edu	37	6	30652329	30652329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30652329G>A	ENST00000274853.3	-	1	3343	c.1467C>T	c.(1465-1467)acC>acT	p.T489T	PPP1R18_ENST00000488324.1_Intron|PPP1R18_ENST00000399199.3_Silent_p.T489T	NM_133471.3	NP_597728.1	Q6NYC8	PHTNS_HUMAN	protein phosphatase 1, regulatory subunit 18	489						cytoplasm|cytoskeleton	actin binding										TGGCTGGAGAGGTTGGGGTGG	0.687000													4	24					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23236971	23236971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23236971C>T	ENST00000400191.3	+	14	2617	c.2599C>T	c.(2599-2601)Cgc>Tgc	p.R867C	EPHB2_ENST00000374632.3_Missense_Mutation_p.R868C|EPHB2_ENST00000374630.3_Missense_Mutation_p.R867C|EPHB2_ENST00000374627.1_Missense_Mutation_p.R862C	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	867	Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GCAGAAGGACCGCAACCACCG	0.587000													28	68					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86198601	86198601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:86198601G>A	ENST00000361228.3	-	2	1555	c.1187C>T	c.(1186-1188)cCc>cTc	p.P396L		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	396					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGAGTAAAGGGAGGAATCTC	0.428000													17	122					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81532943	81532943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81532943G>A	ENST00000548058.1	+	4	1589	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	ACSS3_ENST00000261206.3_Missense_Mutation_p.E226K			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	227						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						ATTTGGCATTGAACCTGGAAG	0.338000													22	64					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127570141	127570141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127570141C>T	ENST00000373580.3	+	7	1250	c.1250C>T	c.(1249-1251)gCc>gTc	p.A417V	OLFML2A_ENST00000288815.5_Missense_Mutation_p.A203V	NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	417	Olfactomedin-like.									endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						CACGAGGGAGCCTGGATGAAG	0.612000													19	38					0	0	1	0	0
RASGRP4	115727	broad.mit.edu	37	19	38910780	38910780	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38910780G>T	ENST00000454404.2	-	5	713	c.500C>A	c.(499-501)tCt>tAt	p.S167Y	RASGRP4_ENST00000426920.2_Missense_Mutation_p.S167Y|RASGRP4_ENST00000433821.2_Missense_Mutation_p.S167Y|RASGRP4_ENST00000586305.1_Missense_Mutation_p.S167Y|RASGRP4_ENST00000587738.1_Missense_Mutation_p.S167Y|RASGRP4_ENST00000293062.9_Missense_Mutation_p.S167Y|RASGRP4_ENST00000587753.1_Missense_Mutation_p.S167Y	NM_001146205.1|NM_170604.2	NP_001139677.1|NP_733749.1	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4	167	N-terminal Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|prostate(3)|skin(1)	23	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAGGTCAGAAGAGTCTCCCAG	0.597000													5	35					0.00198382	0.00198538	1	1	0
ANK2	287	broad.mit.edu	37	4	114153329	114153329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114153329C>T	ENST00000357077.4	+	5	450	c.397C>T	c.(397-399)Cct>Tct	p.P133S	ANK2_ENST00000264366.6_Missense_Mutation_p.P133S|ANK2_ENST00000506722.1_Missense_Mutation_p.P112S|ANK2_ENST00000394537.3_Missense_Mutation_p.P133S	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	133					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGGCTTTACTCCTTTATACAT	0.393000													25	78					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945666	72945666	+	Silent	SNP	C	C	T	rs139591958	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72945666C>T	ENST00000311131.2	+	3	929	c.462C>T	c.(460-462)gcC>gcT	p.A154A	P2RY2_ENST00000393597.2_Silent_p.A154A|P2RY2_ENST00000393596.2_Silent_p.A154A	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	154					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	GCCGGGTGGCCGGGGCCGTGT	0.716000													13	68					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21036508	21036508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21036508G>A	ENST00000381545.3	+	13	1873	c.1654G>A	c.(1654-1656)Ggt>Agt	p.G552S	SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000540229.1_Missense_Mutation_p.G552S|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G552S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.G552S	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	552					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TGCAACAGGAGGTACCACATT	0.343000													12	111					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96961310	96961310	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96961310G>A	ENST00000323853.5	-	14	1835	c.1758C>T	c.(1756-1758)atC>atT	p.I586I	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	586	Helicase ATP-binding 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						GGGTGCAGACGATGATCTGAG	0.572000													18	49					0	0	1	0	0
CWC22	57703	broad.mit.edu	37	2	180846610	180846610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:180846610G>A	ENST00000410053.3	-	5	620	c.321C>T	c.(319-321)tcC>tcT	p.S107S	CWC22_ENST00000295749.6_Silent_p.S107S	NM_020943.2	NP_065994.1	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	107						catalytic step 2 spliceosome	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(8)|stomach(1)	30						CCTGAGCAGAGGAACTCTGAG	0.468000													8	18					0	0	1	0	0
GALNT5	11227	broad.mit.edu	37	2	158114750	158114750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158114750G>A	ENST00000259056.4	+	1	641	c.156G>A	c.(154-156)agG>agA	p.R52R		NM_014568.1	NP_055383.1	Q7Z7M9	GALT5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	52					glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(4)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	56						TTGTGAGGAGGGAGCGGATAG	0.483000													47	147					0	0	1	0	0
ANAPC16	119504	broad.mit.edu	37	10	73983730	73983730	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73983730G>T	ENST00000299381.4	+	2	176	c.58G>T	c.(58-60)Gga>Tga	p.G20*	ANAPC16_ENST00000470481.2_3'UTR	NM_001242546.1|NM_001242547.1|NM_001242548.1|NM_173473.3	NP_001229475.1|NP_001229476.1|NP_001229477.1|NP_775744.1	Q96DE5	APC16_HUMAN	anaphase promoting complex subunit 16	20	Ser-rich.				cell division|mitosis|protein ubiquitination	anaphase-promoting complex|cytoplasm				large_intestine(1)|ovary(1)	2						TTCTGTCACTGGATCTGGTTT	0.493000													51	122					1.17673e-23	1.18424e-23	1	1	0
COL5A3	50509	broad.mit.edu	37	19	10114360	10114360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10114360G>A	ENST00000264828.3	-	6	815	c.730C>T	c.(730-732)Cct>Tct	p.P244S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	244	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TTCCGCCGAGGACGAGGGGTT	0.582000													9	79					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	57009030	57009030	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57009030G>A	ENST00000200676.3	+	10	1078	c.948G>A	c.(946-948)tgG>tgA	p.W316*	CETP_ENST00000566128.1_Nonsense_Mutation_p.W251*|CETP_ENST00000379780.2_Nonsense_Mutation_p.W256*	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	316					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						TGGAGACCTGGGGCTTCAACA	0.537000													17	44					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247464567	247464567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247464567G>A	ENST00000294753.4	-	9	1482	c.1018C>T	c.(1018-1020)Ccg>Tcg	p.P340S	ZNF496_ENST00000462139.1_5'UTR|ZNF496_ENST00000366498.2_Missense_Mutation_p.P376S	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	340					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			AGAGATCGCGGGTTGCCGCCA	0.602000													15	73					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099974	133099974	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133099974C>T	ENST00000515826.1	+	3	1542	c.1419C>T	c.(1417-1419)atC>atT	p.I473I	TMEM108_ENST00000321871.6_Silent_p.I473I|TMEM108_ENST00000393130.3_Silent_p.I473I|TMEM108_ENST00000508711.1_Intron			Q6UXF1	TM108_HUMAN	transmembrane protein 108	473						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						CCTGGGTGATCCTGGCCATCA	0.602000													12	66					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71487187	71487187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71487187G>A	ENST00000393539.2	-	5	914	c.101C>T	c.(100-102)tCt>tTt	p.S34F	AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000358700.2_Missense_Mutation_p.S34F|ZNF23_ENST00000564528.1_5'UTR|ZNF23_ENST00000417828.1_Missense_Mutation_p.S34F|ZNF23_ENST00000497160.1_Missense_Mutation_p.S34F|ZNF23_ENST00000428724.2_5'UTR|ZNF23_ENST00000357254.4_Missense_Mutation_p.S34F|ZNF23_ENST00000539742.1_Intron	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	34	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		AGCCAGTGGAGATGAGCCCCC	0.517000													3	13					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139873732	139873732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139873732C>T	ENST00000224167.2	+	3	387	c.312C>T	c.(310-312)tcC>tcT	p.S104S	PTGDS_ENST00000371625.3_Silent_p.S104S|PTGDS_ENST00000460340.1_3'UTR			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	104					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCCTCGGCTCCTACAGCTACC	0.701000													28	78					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923308	43923308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43923308C>T	ENST00000329196.5	+	1	1053	c.1036C>T	c.(1036-1038)Cgc>Tgc	p.R346C	MAPT-AS1_ENST00000579244.1_RNA|MAPT-AS1_ENST00000579599.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	346						integral to membrane	aspartic-type endopeptidase activity										CAATGAGGACCGCTGGGCGTG	0.637000													17	23					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125487019	125487019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125487019C>T	ENST00000259466.1	+	1	751	c.751C>T	c.(751-753)Ctg>Ttg	p.L251L		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						TGTAGTGGTCCTGTTCTATGG	0.522000													12	133					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	409209	409209	+	Silent	SNP	G	G	A	rs140563600		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:409209G>A	ENST00000280886.6	-	21	2607	c.2520C>T	c.(2518-2520)atC>atT	p.I840I	DIP2C_ENST00000381496.3_3'UTR|DIP2C_ENST00000540204.1_Silent_p.I161I	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	840						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CCACGATCACGATCCTCTCGT	0.647000													18	42					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605341	171605341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171605341G>A	ENST00000037502.5	-	3	1298	c.1239C>T	c.(1237-1239)ctC>ctT	p.L413L		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	413	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AGGTTTGTTCGAGTTCCAGAT	0.522000													55	121					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234113017	234113017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234113017C>T	ENST00000359570.5	+	28	3185	c.3185C>T	c.(3184-3186)cCc>cTc	p.1062_1062insL	INPP5D_ENST00000455936.2_Missense_Mutation_p.826_826insL|INPP5D_ENST00000450745.1_Missense_Mutation_p.826_826insL			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	0	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GGCGAGGGGCCCGGCAAGCAG	0.706000													10	37					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84780088	84780088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:84780088C>T	ENST00000389394.3	+	10	1669	c.1532C>T	c.(1531-1533)cCc>cTc	p.P511L	DNAH6_ENST00000237449.6_Missense_Mutation_p.P511L|DNAH6_ENST00000398278.2_Missense_Mutation_p.P511L	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	511	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						TCTCTCATCCCCATGTTTCTC	0.398000													33	121					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15793285	15793285	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15793285G>A	ENST00000550308.1	+	6	992	c.612G>A	c.(610-612)caG>caA	p.Q204Q	CYP4F12_ENST00000324632.9_Silent_p.Q204Q	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ACAGTCTACAGAAATGCATCT	0.532000													39	146					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2401996	2401996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2401996G>A	ENST00000332578.3	+	4	436	c.436G>A	c.(436-438)Gaa>Aaa	p.E146K		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	146					proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCTTGGCAGAAAGAGACTT	0.443000													61	211					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130613	20130613	+	Missense_Mutation	SNP	C	C	T	rs140830467		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20130613C>T	ENST00000334554.7	+	10	1601	c.1460C>T	c.(1459-1461)tCg>tTg	p.S487L	ZDHHC8_ENST00000320602.7_Missense_Mutation_p.S395L|ZDHHC8_ENST00000405930.3_Missense_Mutation_p.S487L	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	487						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					AATCCTGGCTCGCCTGGTGGC	0.697000													21	51					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152083782	152083782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152083782C>T	ENST00000368804.1	-	2	1910	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	637	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCCTGCTCCTCGCTCTTCA	0.677000													20	142					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15608549	15608549	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:15608549G>A	ENST00000281513.5	-	17	1859	c.1834C>T	c.(1834-1836)Ctg>Ttg	p.L612L	NBAS_ENST00000441750.1_Silent_p.L612L	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	612										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						AGAGCCTCCAGGTCTGTGCCT	0.413000													40	148					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57057430	57057430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:57057430G>A	ENST00000308249.2	+	7	1435	c.1306G>A	c.(1306-1308)Ggc>Agc	p.G436S		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	445	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			GGCCTGTGATGGCTTCTATGA	0.498000													15	30					0	0	1	0	0
LMAN2L	81562	broad.mit.edu	37	2	97373078	97373078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97373078G>A	ENST00000264963.4	-	8	984	c.962C>T	c.(961-963)tCc>tTc	p.S321F	LMAN2L_ENST00000537039.1_Missense_Mutation_p.S183F|LMAN2L_ENST00000377079.4_Missense_Mutation_p.S332F|LMAN2L_ENST00000426463.2_Missense_Mutation_p.S187F|LMAN2L_ENST00000534882.1_Missense_Mutation_p.S176F	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	321					ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						AAACACCAGGGAGAAAAAGAC	0.522000													19	35					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152323637	152323637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152323637C>T	ENST00000388718.5	-	3	6697	c.6625G>A	c.(6625-6627)Gga>Aga	p.G2209R	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2209							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGACTGTCCATGTCGAGAT	0.507000													41	468					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76023520	76023520	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76023520G>A	ENST00000393004.2	-	5	2249	c.2028C>T	c.(2026-2028)ttC>ttT	p.F676F	FILIP1_ENST00000237172.7_Silent_p.F676F|FILIP1_ENST00000370020.1_Silent_p.F577F|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	676								p.F676F(1)		breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GTTGAGAGAGGAAGTTAGCCT	0.433000													117	202					0	0	1	0	0
MEF2A	4205	broad.mit.edu	37	15	100214787	100214787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:100214787C>T	ENST00000354410.5	+	6	1215	c.586C>T	c.(586-588)Cct>Tct	p.P196S	MEF2A_ENST00000338042.6_Missense_Mutation_p.P194S|MEF2A_ENST00000453228.2_Missense_Mutation_p.P194S|MEF2A_ENST00000449277.2_Missense_Mutation_p.P126S|MEF2A_ENST00000558812.1_Missense_Mutation_p.P126S|MEF2A_ENST00000557785.1_Missense_Mutation_p.P194S|MEF2A_ENST00000557942.1_Missense_Mutation_p.P194S	NM_005587.2	NP_005578.2	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A	196					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding	p.P196S(2)|p.P194S(1)		endometrium(2)|large_intestine(2)|lung(7)|ovary(1)	12	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			TCCTGGAGCTCCTCAGAGACC	0.433000													14	182					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107018	121107018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:121107018C>T	ENST00000295228.3	+	2	838	c.792C>T	c.(790-792)ttC>ttT	p.F264F		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	264					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				TGCCGGTGTTCGTGGACCCAG	0.667000													37	91					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20709625	20709625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20709625G>A	ENST00000359062.3	+	2	1032	c.992G>A	c.(991-993)cGa>cAa	p.R331Q		NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	331					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GACCACAAACGAGGGCCAAGA	0.348000													17	146					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160093842	160093842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160093842C>T	ENST00000361216.3	+	5	580	c.491C>T	c.(490-492)cCt>cTt	p.P164L	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Missense_Mutation_p.P164L	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	164					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AACATGGTACCTCAGGTAAGA	0.532000													17	57					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64421078	64421078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:64421078C>T	ENST00000262043.3	+	15	4157	c.3817C>T	c.(3817-3819)Cgc>Tgc	p.R1273C	PHF3_ENST00000393387.1_Missense_Mutation_p.R1273C			Q92576	PHF3_HUMAN	PHD finger protein 3	1273					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TTGTGTGGTTCGCTTCACACC	0.323000													10	31					0	0	1	0	0
FUT5	2527	broad.mit.edu	37	19	5867495	5867495	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5867495C>T	ENST00000252675.5	-	5	804	c.242G>A	c.(241-243)tGg>tAg	p.W81*	FUT5_ENST00000588525.1_Nonsense_Mutation_p.W81*			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	81					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						AGGCCACGTCCACAGCAGGAT	0.652000													17	59					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58055936	58055936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:58055936G>A	ENST00000556826.1	-	3	821	c.585C>T	c.(583-585)ttC>ttT	p.F195F	SLC35F4_ENST00000554729.1_Silent_p.F72F|SLC35F4_ENST00000339762.6_Silent_p.F231F	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AAACCTACCTGAATTTTTTCA	0.338000													30	77					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44004474	44004474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44004474G>A	ENST00000262726.7	-	22	2822	c.2569C>T	c.(2569-2571)Cta>Tta	p.L857L	EFCAB6_ENST00000396231.2_Silent_p.L705L	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	857	EF-hand 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TCGGTTTCTAGAAAATTCTAC	0.398000													36	57					0	0	1	0	0
SLC26A6	65010	broad.mit.edu	37	3	48663735	48663735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48663735G>A	ENST00000358747.6	-	19	2368	c.2118C>T	c.(2116-2118)acC>acT	p.T706T	SLC26A6_ENST00000420764.2_Silent_p.T726T|SLC26A6_ENST00000455886.2_Silent_p.T691T|SLC26A6_ENST00000337000.8_Silent_p.T619T|SLC26A6_ENST00000383733.3_Silent_p.T708T|SLC26A6_ENST00000395550.2_Silent_p.T727T	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		GATGCTTCTTGGTGATGGATG	0.582000													13	79					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71976274	71976274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71976274G>A	ENST00000266674.5	+	17	1902	c.1591G>A	c.(1591-1593)Gaa>Aaa	p.E531K	RP11-186F10.2_ENST00000546601.1_RNA|LGR5_ENST00000540815.2_Missense_Mutation_p.E507K|LGR5_ENST00000536515.1_Missense_Mutation_p.E459K			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	531						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TGACTTTGAGGAAGACCTGAA	0.463000													9	89					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13418643	13418643	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13418643G>A	ENST00000360228.5	-	15	1938	c.1939C>T	c.(1939-1941)Ccc>Tcc	p.P647S	CACNA1A_ENST00000573710.2_Missense_Mutation_p.P648S	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	648					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AAGTTGGTGGGAGGAGTCCCT	0.542000													27	83					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640283	34640283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34640283G>A	ENST00000537011.1	+	3	596	c.214G>A	c.(214-216)Gag>Aag	p.E72K	NUTM1_ENST00000333756.4_Missense_Mutation_p.E44K|NUTM1_ENST00000438749.3_Missense_Mutation_p.E62K					NUT midline carcinoma, family member 1																		CCCACCCAGGGAGCCACCTCC	0.592000													50	126					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469264	10469264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10469264C>T	ENST00000382483.3	-	4	2567	c.2344G>A	c.(2344-2346)Gac>Aac	p.D782N		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	782					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GAGCAGGAGTCGGATGTGTGG	0.667000													13	83					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231120199	231120199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231120199G>A	ENST00000392045.3	+	12	1306	c.1192G>A	c.(1192-1194)Gga>Aga	p.G398R	SP140_ENST00000417495.3_Missense_Mutation_p.G284R|SP140_ENST00000486687.2_Missense_Mutation_p.G322R|SP140_ENST00000420434.3_Intron|SP140_ENST00000350136.5_Missense_Mutation_p.G267R|SP140_ENST00000343805.6_Missense_Mutation_p.G338R	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	398					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AATGTGTGATGGAGAAGAGCG	0.527000													22	72					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11702695	11702695	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11702695C>T	ENST00000381486.2	+	3	564	c.264C>T	c.(262-264)tgC>tgT	p.C88C	GREB1_ENST00000263834.5_Silent_p.C88C|GREB1_ENST00000234142.5_Silent_p.C88C|GREB1_ENST00000389825.3_5'UTR|GREB1_ENST00000381483.2_Silent_p.C88C	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	88						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CTGAAGGATGCTGTACCACAG	0.627000													21	109					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149260062	149260062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:149260062C>T	ENST00000407073.1	+	13	5318	c.4321C>T	c.(4321-4323)Cgg>Tgg	p.R1441W	MBD5_ENST00000404807.1_Missense_Mutation_p.R1674W	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1441	PWWP.					chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CAGCCGTGTCCGGAAAAGGAA	0.413000													9	41					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76928970	76928970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76928970C>T	ENST00000380887.2	+	3	552	c.480C>T	c.(478-480)ttC>ttT	p.F160F	ESRRB_ENST00000509242.1_Silent_p.F160F|ESRRB_ENST00000261532.7_Silent_p.F160F|ESRRB_ENST00000556177.1_Silent_p.F160F|ESRRB_ENST00000507951.1_3'UTR			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	160						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CCTGCCGCTTCATGAAATGCC	0.582000													52	113					0	0	1	0	0
GM2A	2760	broad.mit.edu	37	5	150646957	150646957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150646957G>A	ENST00000357164.3	+	4	852	c.527G>A	c.(526-528)aGc>aAc	p.S176N		NM_000405.4|NM_001167607.1	NP_000396.2|NP_001161079.1	P17900	SAP3_HUMAN	GM2 ganglioside activator	176						lysosome|nucleolus	sphingolipid activator protein activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|upper_aerodigestive_tract(2)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTCCTGAGCAGCAGTGGGAAG	0.577000													12	51					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103124627	103124627	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103124627C>T	ENST00000295269.4	+	5	1745	c.1288C>T	c.(1288-1290)Cga>Tga	p.R430*		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	430					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CAGTGGTGTTCGAGGAGCTGG	0.413000													39	86					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6925421	6925421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6925421C>T	ENST00000011653.4	+	6	1065	c.807C>T	c.(805-807)gaC>gaT	p.D269D	CD4_ENST00000541982.1_3'UTR|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	269	Ig-like C2-type 2.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding	p.D269E(1)		breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				TTACCCAGGACCCTAAGCTCC	0.587000													25	95					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43332482	43332482	+	Silent	SNP	C	C	T	rs148517689		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43332482C>T	ENST00000380486.3	-	7	1153	c.912G>A	c.(910-912)acG>acA	p.T304T	C2CD2_ENST00000329623.7_Silent_p.T149T	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	304	C2.					cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						GAGTGTTTTTCGTCAGGGTGC	0.542000													3	22					0	0	1	0	0
BIRC8	112401	broad.mit.edu	37	19	53793021	53793021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53793021G>A	ENST00000426466.1	-	1	1854	c.607C>T	c.(607-609)Cct>Tct	p.P203S		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	203					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		TGTCCACAAGGAATAAAAACA	0.438000													25	81					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64514191	64514191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64514191C>T	ENST00000164139.3	-	20	2867	c.2469G>A	c.(2467-2469)cgG>cgA	p.R823R	PYGM_ENST00000377432.3_Silent_p.R735R	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	823					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	CCCAGATCTCCCGGGCATACT	0.617000													20	63					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10083692	10083692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10083692C>T	ENST00000264828.3	-	51	3762	c.3677G>A	c.(3676-3678)gGa>gAa	p.G1226E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1226	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			ACCAATGTCTCCCTTGGGCCC	0.577000													8	16					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294748	124294748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124294748G>A	ENST00000356130.3	-	1	41	c.20C>T	c.(19-21)tCc>tTc	p.S7F		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S7F(1)		endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGTCACTGAGGAGCTGTTTCT	0.483000													10	44					0	0	1	0	0
SLC20A2	6575	broad.mit.edu	37	8	42320605	42320605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42320605G>A	ENST00000342228.3	-	4	803	c.434C>T	c.(433-435)gCt>gTt	p.A145V	SLC20A2_ENST00000520179.1_Missense_Mutation_p.A145V|SLC20A2_ENST00000520262.1_Missense_Mutation_p.A145V	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	145					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AAACCAAGAAGCAACTGAATA	0.308000													4	42					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113562671	113562671	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113562671C>T	ENST00000416899.2	+	13	2115	c.1989C>T	c.(1987-1989)tcC>tcT	p.S663S	MUSK_ENST00000374448.4_Silent_p.S671S|MUSK_ENST00000189978.5_Silent_p.S671S			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	671	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						GCAGCATGTCCCCTCACACCG	0.572000													35	120					0	0	1	0	0
C18orf25	147339	broad.mit.edu	37	18	43796350	43796350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43796350C>T	ENST00000282059.6	+	2	878	c.504C>T	c.(502-504)gtC>gtT	p.V168V	C18orf25_ENST00000321319.6_Silent_p.V168V	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	168										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						ATGGCCGAGTCGCCAAGGTTA	0.517000													20	74					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885004	29885004	+	Missense_Mutation	SNP	G	G	A	rs59297913		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29885004G>A	ENST00000310624.6	+	4	1408	c.1375G>A	c.(1375-1377)Gaa>Aaa	p.E459K		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	459	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						GATTGTGGAGGAACAGACAGA	0.478000													17	48					0	0	1	0	0
APOL1	8542	broad.mit.edu	37	22	36661745	36661745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36661745G>A	ENST00000319136.4	+	7	1178	c.911G>A	c.(910-912)cGa>cAa	p.R304Q	APOL1_ENST00000397279.4_Missense_Mutation_p.R288Q|APOL1_ENST00000422706.1_Missense_Mutation_p.R288Q|APOL1_ENST00000347595.7_Missense_Mutation_p.R167Q|APOL1_ENST00000426053.1_Missense_Mutation_p.R270Q|APOL1_ENST00000397278.3_Missense_Mutation_p.R288Q	NM_145343.2	NP_663318.1	O14791	APOL1_HUMAN	apolipoprotein L, 1	288					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	14						GCCCTCAGACGAGCCAGAGCC	0.537000													29	83					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48428731	48428731	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48428731G>A	ENST00000224605.2	-	2	1420	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	385					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity	p.F385F(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CGATGTCTGCGAAGTCCACCT	0.552000													34	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060664	9060664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9060664C>T	ENST00000397910.4	-	3	26985	c.26782G>A	c.(26782-26784)Gag>Aag	p.E8928K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8930	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCTCTGTCTCCATGGTGGCT	0.488000													63	184					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870387	4870387	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4870387G>A	ENST00000322101.2	-	1	127	c.52C>T	c.(52-54)Ccc>Tcc	p.P18S	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGAAGGTGGGGGCCATTGAA	0.507000													36	77					0	0	1	0	0
RSPO1	284654	broad.mit.edu	37	1	38078497	38078497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38078497C>T	ENST00000356545.2	-	8	1509	c.722G>A	c.(721-723)aGa>aAa	p.R241K	RSPO1_ENST00000401071.2_Missense_Mutation_p.R178K|RSPO1_ENST00000401069.1_Missense_Mutation_p.R241K|RSPO1_ENST00000373059.1_Missense_Mutation_p.R214K|RSPO1_ENST00000401070.1_Missense_Mutation_p.R178K|RSPO1_ENST00000401068.1_Missense_Mutation_p.R241K	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1	241					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCCTTGCGTCTTCGAGAGCC	0.652000													38	109					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169697034	169697034	+	Silent	SNP	C	C	T	rs147467969	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169697034C>T	ENST00000333360.7	-	9	1453	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K	SELE_ENST00000367780.4_Silent_p.K313K|SELE_ENST00000367781.4_Silent_p.K375K|SELE_ENST00000367779.4_Intron|SELE_ENST00000367782.4_Intron|SELE_ENST00000367777.1_Intron|SELE_ENST00000367775.1_Silent_p.K313K|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367776.1_Silent_p.K375K|SELE_ENST00000367774.1_Intron	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	438	Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TCACCAAACCCTTCGGGGGCT	0.488000													28	92					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28828806	28828806	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:28828806G>A	ENST00000422425.2	+	41	3059	c.3015G>A	c.(3013-3015)tgG>tgA	p.W1005*	PLB1_ENST00000541605.1_Intron|PLB1_ENST00000327757.5_Nonsense_Mutation_p.W1016*	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1016	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GAGCCCTTTGGACCAATATGG	0.522000													58	141					0	0	1	0	0
ZNF429	353088	broad.mit.edu	37	19	21720271	21720271	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21720271G>A	ENST00000358491.4	+	4	1624	c.1416G>A	c.(1414-1416)agG>agA	p.R472R	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						CTAGCCATAGGAGAATTCATA	0.383000													23	89					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17353332	17353332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:17353332C>T	ENST00000261381.6	-	3	510	c.426G>A	c.(424-426)ccG>ccA	p.P142P		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	142					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTTTCTCTTTCGGCCGATGAG	0.478000													23	81					0	0	1	0	0
TIA1	7072	broad.mit.edu	37	2	70441545	70441545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70441545G>A	ENST00000433529.2	-	12	1180	c.970C>T	c.(970-972)Cct>Tct	p.P324S	C2orf42_ENST00000470096.1_Intron|TIA1_ENST00000282574.4_Missense_Mutation_p.P323S|TIA1_ENST00000445587.1_Intron|TIA1_ENST00000415783.2_Missense_Mutation_p.P313S	NM_022173.2	NP_071505.2	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein	324					apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	17						CAACCATTAGGCATATACTGG	0.403000													16	62					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23713758	23713758	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23713758C>T	ENST00000256797.4	-	10	1346	c.1178G>A	c.(1177-1179)aGa>aAa	p.R393K	ERN2_ENST00000457008.2_Missense_Mutation_p.R345K	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	345					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TGAGGGGTATCTAACAGCAGT	0.582000													51	140					0	0	1	0	0
TRBV4-1	28617	broad.mit.edu	37	7	142013066	142013066	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142013066C>T	ENST00000390357.3	+	0	60																											CTGTGCGGTTCTCTGTCTCCT	0.592000													32	57					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497184	141497184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141497184C>T	ENST00000264952.2	+	1	195	c.58C>T	c.(58-60)Cgg>Tgg	p.R20W		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	20					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CCTGCAGGCCCGGAAGCCCTC	0.697000													35	72					0	0	1	0	0
RBP1	5947	broad.mit.edu	37	3	139237318	139237318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:139237318C>T	ENST00000232219.2	-	3	595	c.485G>A	c.(484-486)gGt>gAt	p.G162D	RP11-319G6.1_ENST00000515247.1_RNA	NM_002899.3	NP_002890.2	P09455	RET1_HUMAN	retinol binding protein 1, cellular	100						cytoplasm	retinal binding|retinol binding|transporter activity			endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	5					Vitamin A(DB00162)	CTCCTTCTCACCCTTCTGCAC	0.612000													5	79					0	0	1	0	0
SRSF6	6431	broad.mit.edu	37	20	42088473	42088473	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42088473C>T	ENST00000244020.3	+	3	425	c.319C>T	c.(319-321)Cgt>Tgt	p.R107C		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	107					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding	p.R107C(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						ACCACCTGTTCGTACAGAATA	0.393000													37	111					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68777148	68777148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68777148C>T	ENST00000508048.1	-	10	1201	c.1166G>A	c.(1165-1167)gGa>gAa	p.G389E	TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.G390E|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.G393E			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	393	Peptidase S1.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						ACAGTTATCTCCCCAGCTTAC	0.388000													31	102					0	0	1	0	0
KIF3A	11127	broad.mit.edu	37	5	132062122	132062122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132062122G>A	ENST00000378746.4	-	3	567	c.349C>T	c.(349-351)Cct>Tct	p.P117S	KIF3A_ENST00000403231.1_Missense_Mutation_p.P117S|KIF3A_ENST00000378735.1_Missense_Mutation_p.P117S	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	117	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTAAGTTCAGGAATAGCTCGA	0.368000													36	111					0	0	1	0	0
C17orf64	124773	broad.mit.edu	37	17	58506739	58506739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58506739C>T	ENST00000269127.4	+	5	530	c.446C>T	c.(445-447)tCg>tTg	p.S149L		NM_181707.2	NP_859058.2	Q86WR6	CQ064_HUMAN	chromosome 17 open reading frame 64	149										breast(2)|large_intestine(1)|lung(3)	6	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;5.81e-13)|all cancers(12;2.17e-11)|Colorectal(3;0.01)			TTCTGCGCCTCGGATGCGCCG	0.587000													12	42					0	0	1	0	0
C20orf96	140680	broad.mit.edu	37	20	257964	257964	+	Missense_Mutation	SNP	T	T	C	rs144025240		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:257964T>C	ENST00000360321.2	-	7	764	c.626A>G	c.(625-627)aAc>aGc	p.N209S	C20orf96_ENST00000400269.3_Missense_Mutation_p.N151S|C20orf96_ENST00000382369.5_Missense_Mutation_p.N174S	NM_080571.1|NM_153269.2	NP_542138.1|NP_695001.2	Q9NUD7	CT096_HUMAN	chromosome 20 open reading frame 96	209										endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12		all_cancers(10;0.00959)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GCTCAGGAAGTTCACTTCCTC	0.537000													90	209					0	0	1	0	0
CD48	962	broad.mit.edu	37	1	160648910	160648910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160648910C>T	ENST00000368046.3	-	4	751	c.664G>A	c.(664-666)Gga>Aga	p.G222R	RP11-404F10.2_ENST00000443928.2_RNA|RP11-404F10.2_ENST00000588034.1_RNA	NM_001778.3	NP_001769.2	P09326	CD48_HUMAN	CD48 molecule	222					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CATTCTACTCCAAAGGACCGG	0.453000													17	48					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52508883	52508883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52508883G>A	ENST00000216286.5	-	7	1764	c.1765C>T	c.(1765-1767)Ctg>Ttg	p.L589L	NID2_ENST00000541773.1_Silent_p.L536L	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	589	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CAGCCAAACAGGCCTCCAATT	0.582000													79	138					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80203349	80203349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:80203349C>T	ENST00000392959.1	-	5	1450	c.839G>A	c.(838-840)cGa>cAa	p.R280Q	LCA5_ENST00000369846.4_Missense_Mutation_p.R280Q|LCA5_ENST00000467898.2_Missense_Mutation_p.R280Q	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	280					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		GTGATATAGTCGCTGTACCTC	0.308000													19	27					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914337	107914337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107914337C>T	ENST00000280758.5	+	2	1737	c.1209C>T	c.(1207-1209)ccC>ccT	p.P403P	BTBD11_ENST00000420571.2_Silent_p.P403P|BTBD11_ENST00000490090.2_Silent_p.P403P	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	403						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GGGAACTGCCCATGTTCAGCC	0.567000													13	128					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33031966	33031966	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:33031966C>T	ENST00000340811.4	-	2	332	c.223_splice	c.e2-1	p.G75_splice	PKP2_ENST00000070846.6_Splice_Site_p.G75_splice	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	75					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GTGAAGATTTCCTGCAATCAA	0.333000													5	42					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572149	140572149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140572149C>T	ENST00000239446.4	+	1	208	c.24C>T	c.(22-24)ttC>ttT	p.F8F		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		8					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTTGTGCTTCCCAAGACAAA	0.473000													58	158					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593660	179593660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179593660C>T	ENST00000589042.1	-	65	19329	c.19105G>A	c.(19105-19107)Gag>Aag	p.E6369K	TTN_ENST00000342992.6_Missense_Mutation_p.E5125K|TTN_ENST00000591111.1_Missense_Mutation_p.E6052K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6052	Ig-like 45.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCTGACTCATTCTTGGCT	0.388000													13	21					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11058943	11058943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11058943G>A	ENST00000287766.4	+	3	467	c.46G>A	c.(46-48)Gag>Aag	p.E16K	SLC6A1_ENST00000536032.1_5'UTR|SLC6A1-AS1_ENST00000414969.2_RNA|SLC6A1_ENST00000462473.1_3'UTR	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	16					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	GATCTCCACCGAGGTCAGCGA	0.642000													16	55					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17446124	17446124	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17446124C>A	ENST00000400588.1	-	7	1430	c.1323G>T	c.(1321-1323)agG>agT	p.R441S		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	441										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				CATTGATGACCCTGTTGTTTC	0.557000													10	37					1.08611e-07	1.08924e-07	1	1	0
VPS13D	55187	broad.mit.edu	37	1	12343258	12343258	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12343258T>A	ENST00000358136.3	+	21	5229	c.5099T>A	c.(5098-5100)tTa>tAa	p.L1700*	VPS13D_ENST00000356315.4_Nonsense_Mutation_p.L1700*	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1700					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCATCTAGTTTAGCACAAAAA	0.468000													54	113					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915564	119915564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:119915564G>A	ENST00000331113.4	+	1	1843	c.878G>A	c.(877-879)cGa>cAa	p.R293Q		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	293					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GTCACACTCCGAGTCTTCCGG	0.527000													14	31					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898490	175898490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175898490G>A	ENST00000359240.3	+	5	2484	c.1814G>A	c.(1813-1815)gGg>gAg	p.G605E	ADAM29_ENST00000445694.1_Missense_Mutation_p.G605E|ADAM29_ENST00000404450.4_Missense_Mutation_p.G605E|ADAM29_ENST00000514159.1_Missense_Mutation_p.G605E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	605	Cys-rich.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACAGAGTGTGGGATAGATCAT	0.428000													46	157					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28592681	28592681	+	Missense_Mutation	SNP	C	C	T	rs148480385		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28592681C>T	ENST00000380982.4	-	20	2545	c.2464G>A	c.(2464-2466)Ggg>Agg	p.G822R	FLT3_ENST00000537084.1_Intron|FLT3_ENST00000241453.7_Missense_Mutation_p.G822R			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	822	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACCACTTTCCCGTGGGTGACA	0.463000			"""Mis, O"""		"""AML, ALL"""								17	72					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102057327	102057327	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102057327G>A	ENST00000318222.3	-	5	1150	c.768C>T	c.(766-768)ttC>ttT	p.F256F	PKD2L1_ENST00000353274.3_Silent_p.F256F|PKD2L1_ENST00000338519.3_Intron	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	256					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CCCAGTGGGAGAAGCCCCCCA	0.592000													8	40					0	0	1	0	0
GIPR	2696	broad.mit.edu	37	19	46177384	46177384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46177384C>T	ENST00000590918.1	+	6	536	c.437C>T	c.(436-438)tCc>tTc	p.S146F	GIPR_ENST00000263281.3_Missense_Mutation_p.S146F|GIPR_ENST00000304207.8_Missense_Mutation_p.S110F	NM_000164.2	NP_000155.1	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	146					generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				endometrium(1)|kidney(2)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	12		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		GTCGGCTACTCCCTGTCTCTC	0.592000													64	178					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156651215	156651215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156651215C>T	ENST00000296518.7	+	10	2114	c.1905C>T	c.(1903-1905)acC>acT	p.T635T	GUCY1A3_ENST00000393832.3_Silent_p.T377T|GUCY1A3_ENST00000506455.1_Silent_p.T635T|GUCY1A3_ENST00000513574.1_Silent_p.T635T|GUCY1A3_ENST00000511108.1_Silent_p.T635T|GUCY1A3_ENST00000455639.2_Silent_p.T635T			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	635					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity	p.T635T(1)		central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TCGTGTTTACCCCTCGATCAA	0.378000													17	97					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233394685	233394685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233394685G>A	ENST00000258385.3	+	7	688	c.656G>A	c.(655-657)aGg>aAg	p.R219K	CHRND_ENST00000457943.2_Intron|CHRND_ENST00000536614.1_Silent_p.Q182Q|CHRND_ENST00000543200.1_Missense_Mutation_p.R204K	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	219					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CGGCCGGCCAGGGTCAACGTG	0.647000													18	99					0	0	1	0	0
TNNT1	7138	broad.mit.edu	37	19	55652271	55652271	+	Missense_Mutation	SNP	C	C	T	rs150477069		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55652271C>T	ENST00000588981.1	-	9	571	c.367G>A	c.(367-369)Gaa>Aaa	p.E123K	TNNT1_ENST00000291901.8_Missense_Mutation_p.E123K|TNNT1_ENST00000536926.1_Missense_Mutation_p.E112K|TNNT1_ENST00000587758.1_Missense_Mutation_p.E112K|TNNT1_ENST00000592920.1_5'UTR|TNNT1_ENST00000585321.2_Missense_Mutation_p.E53K|TNNT1_ENST00000588426.1_Missense_Mutation_p.E20K|TNNT1_ENST00000356783.5_Missense_Mutation_p.E112K|TNNT1_ENST00000587465.2_Missense_Mutation_p.E53K	NM_003283.4	NP_003274.3	P13805	TNNT1_HUMAN	troponin T type 1 (skeletal, slow)	123					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		GCCTGACGTTCGCGTTCCTTC	0.552000													39	50					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169711903	169711903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169711903G>A	ENST00000444448.2	+	14	1544	c.1068G>A	c.(1066-1068)aaG>aaA	p.K356K	NOSTRIN_ENST00000458381.2_Silent_p.K356K|NOSTRIN_ENST00000421711.2_Silent_p.K271K|NOSTRIN_ENST00000397209.2_Silent_p.K271K|NOSTRIN_ENST00000317647.7_Silent_p.K299K|NOSTRIN_ENST00000397206.2_Silent_p.K221K|NOSTRIN_ENST00000445023.2_Silent_p.K221K			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	299					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						AGAGACGAAAGTCTTTACTAA	0.388000													10	66					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701922	56701922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56701922C>T	ENST00000586855.2	-	5	1075	c.762G>A	c.(760-762)ggG>ggA	p.G254G	ZSCAN5B_ENST00000358992.3_Silent_p.G254G			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	254					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GGGGTTCCTTCCCCTCCTTTG	0.488000													37	81					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32379054	32379054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32379054C>T	ENST00000375200.1	+	15	2661	c.2296C>T	c.(2296-2298)Ccc>Tcc	p.P766S	RP4-553F4.6_ENST00000423074.1_RNA|ZNF341_ENST00000342427.2_Missense_Mutation_p.P759S|RP4-553F4.6_ENST00000443171.1_RNA|RP4-553F4.6_ENST00000439444.1_RNA			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	766					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GGTGCTGACCCCCTTGCCTGA	0.721000													15	29					0	0	1	0	0
IFNL3	282617	broad.mit.edu	37	19	39735067	39735067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39735067C>T	ENST00000413851.2	-	2	286	c.248G>A	c.(247-249)aGg>aAg	p.R83K		NM_172139.2	NP_742151.2			interferon, lambda 3																		CTGCAGCTGCCTCAGGTCCCA	0.632000													4	25					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43243749	43243749	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43243749G>A	ENST00000255226.6	+	11	2167		c.e11-1		SLC14A2_ENST00000586448.1_Splice_Site	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2							apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCCCTGGCTAGGAGGCGGTGG	0.582000													17	32					0	0	1	0	0
EYA2	2139	broad.mit.edu	37	20	45725748	45725748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45725748G>A	ENST00000327619.5	+	9	1203	c.829G>A	c.(829-831)Gag>Aag	p.E277K	EYA2_ENST00000357410.3_Missense_Mutation_p.E277K|EYA2_ENST00000317304.6_Missense_Mutation_p.E277K	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	277					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				GGACTTGGATGAGACAATAAT	0.403000													60	183					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74631996	74631996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74631996G>A	ENST00000358632.4	-	6	1310	c.615C>T	c.(613-615)gcC>gcT	p.A205A	CYP11A1_ENST00000419019.2_Silent_p.A205A|CYP11A1_ENST00000268053.6_Silent_p.A363A	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	363					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TGTCTCCCTGGGCCTGGTGCC	0.612000													36	35					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118196347	118196347	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118196347C>T	ENST00000369230.3	+	2	320	c.174C>T	c.(172-174)ctC>ctT	p.L58L		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	58					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		GTTTCCTGCTCTACACTATAC	0.408000													17	159					0	0	1	0	0
CTC-260F20.3	0	broad.mit.edu	37	19	19638102	19638102	+	Silent	SNP	C	C	T	rs140748603		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19638102C>T	ENST00000555938.1	+	3	198	c.186C>T	c.(184-186)atC>atT	p.I62I	NDUFA13_ENST00000503283.1_Silent_p.I62I|NDUFA13_ENST00000252576.5_Silent_p.I145I|NDUFA13_ENST00000507754.3_Silent_p.I62I|CTC-260F20.3_ENST00000586674.1_3'UTR|NDUFA13_ENST00000428459.2_Silent_p.I62I																							GCCTACAAATCGAGGACTTCG	0.637000													23	50					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042757	75042757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75042757C>T	ENST00000343932.4	+	2	741	c.678C>T	c.(676-678)ttC>ttT	p.F226F		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	226					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding	p.F226F(2)		breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CTCATGAGTTCGTGGAGACTG	0.572000													38	252					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124395538	124395538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124395538G>A	ENST00000338354.3	+	50	6299	c.6193G>A	c.(6193-6195)Gaa>Aaa	p.E2065K	DMBT1_ENST00000344338.3_Missense_Mutation_p.E2055K|DMBT1_ENST00000368955.3_Missense_Mutation_p.E2055K|DMBT1_ENST00000359586.6_Missense_Mutation_p.E785K|DMBT1_ENST00000330163.4_Missense_Mutation_p.E1437K|DMBT1_ENST00000368956.2_Missense_Mutation_p.E1437K|DMBT1_ENST00000368909.3_Missense_Mutation_p.E2065K			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2065	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGATTATATTGAAGTTTTCGA	0.507000													19	52					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169698359	169698359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169698359C>T	ENST00000333360.7	-	7	1197	c.1058G>A	c.(1057-1059)gGg>gAg	p.G353E	SELE_ENST00000367780.4_Missense_Mutation_p.G291E|SELE_ENST00000367781.4_Missense_Mutation_p.G353E|SELE_ENST00000367779.4_Missense_Mutation_p.G353E|SELE_ENST00000367782.4_Missense_Mutation_p.G353E|SELE_ENST00000367777.1_Missense_Mutation_p.G353E|SELE_ENST00000367775.1_Missense_Mutation_p.G291E|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367776.1_Missense_Mutation_p.G353E|SELE_ENST00000367774.1_Missense_Mutation_p.G353E	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	353	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TGTCCACTGCCCTTGAGTGGT	0.463000													26	56					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111584888	111584888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:111584888G>A	ENST00000428084.1	-	10	1094	c.822C>T	c.(820-822)atC>atT	p.I274I	DOCK4_ENST00000476846.1_5'UTR|DOCK4_ENST00000437633.1_Silent_p.I274I			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	274					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TGTGCACGGTGATATAAATGT	0.433000													12	43					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21186092	21186092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21186092C>T	ENST00000377122.4	-	1	439	c.43G>A	c.(43-45)Gaa>Aaa	p.E15K	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron|NEBL_ENST00000377119.1_Missense_Mutation_p.E15K	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	15					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						atcttttcttcttcagtttca	0.333000													8	25					0	0	1	0	0
SPANXN1	494118	broad.mit.edu	37	X	144329145	144329145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:144329145G>A	ENST00000370493.3	+	1	798	c.39G>A	c.(37-39)agG>agA	p.R13R		NM_001009614.2	NP_001009614.1	Q5VSR9	SPXN1_HUMAN	SPANX family, member N1	13										endometrium(2)|kidney(2)|lung(8)|prostate(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGAAGAGGAAGAGCCCCT	0.463000													90	60					0	0	1	0	0
PDGFC	56034	broad.mit.edu	37	4	157689119	157689119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:157689119C>T	ENST00000502773.1	-	5	1217	c.727G>A	c.(727-729)Gag>Aag	p.E243K	PDGFC_ENST00000504672.1_5'UTR|PDGFC_ENST00000542208.1_Missense_Mutation_p.E88K|PDGFC_ENST00000541126.1_Missense_Mutation_p.E80K|PDGFC_ENST00000422544.2_Missense_Mutation_p.E243K	NM_016205.2	NP_057289.1	Q9NRA1	PDGFC_HUMAN	platelet derived growth factor C	243					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		CTTACCTCCTCTGTTAGAAGG	0.393000													67	146					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304276	10304276	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10304276C>T	ENST00000403437.2	-	26	3349	c.3254_splice	c.e26-1	p.K1085_splice	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1085					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CAAATTCTTTCCTTTAGACAG	0.333000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				20	30					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111997701	111997701	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111997701G>A	ENST00000305815.5	-	4	445	c.193C>T	c.(193-195)Caa>Taa	p.Q65*	SLC9C1_ENST00000487372.1_Nonsense_Mutation_p.Q65*|SLC9C1_ENST00000467397.1_5'UTR	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	65					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										GCGTATCTTTGGACCTAATAT	0.323000													37	100					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70818641	70818641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:70818641C>T	ENST00000358731.4	+	24	5515	c.5252C>T	c.(5251-5253)tCc>tTc	p.S1751F	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1751					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TGTGTAGGTTCCAAAGAGTCT	0.378000													26	74					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3675093	3675093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3675093G>A	ENST00000344754.4	-	12	3030	c.3031C>T	c.(3031-3033)Cct>Tct	p.P1011S	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.P1011S	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1011	Ig-like C2-type 10.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						TGGGCCGGAGGGTCACTGTCC	0.672000													6	18					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203025996	203025996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203025996C>T	ENST00000367240.2	+	18	2789	c.2262C>T	c.(2260-2262)atC>atT	p.I754I	PPFIA4_ENST00000414050.2_Silent_p.I482I|PPFIA4_ENST00000599966.1_Silent_p.I269I|PPFIA4_ENST00000447715.2_Silent_p.I753I|PPFIA4_ENST00000295706.4_Silent_p.I269I|PPFIA4_ENST00000272198.6_Silent_p.I269I			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	269					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						GCAAGGGCATCAAGTCGTCCA	0.617000													12	35					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11725328	11725328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11725328G>A	ENST00000381486.2	+	8	1243	c.943G>A	c.(943-945)Ggg>Agg	p.G315R	GREB1_ENST00000263834.5_Missense_Mutation_p.G315R|GREB1_ENST00000234142.5_Missense_Mutation_p.G315R|GREB1_ENST00000381483.2_Missense_Mutation_p.G315R	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	315						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACGCCACAAAGGGTGGTCTCC	0.502000													15	26					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11052763	11052763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11052763G>A	ENST00000295082.1	+	1	701	c.211G>A	c.(211-213)Gac>Aac	p.D71N		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	71						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CGACGACTACGACCCCGGCAA	0.597000													18	34					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300558	88300558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88300558G>A	ENST00000418177.2	-	8	2660	c.2293C>T	c.(2293-2295)Cca>Tca	p.P765S	GRM5_ENST00000455756.2_Missense_Mutation_p.P765S|GRM5_ENST00000305447.4_Missense_Mutation_p.P765S|GRM5_ENST00000393297.1_Missense_Mutation_p.P765S|GRM5_ENST00000305432.5_Missense_Mutation_p.P765S			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	765					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AAGTTAGCTGGAACATTTCTG	0.438000													52	137					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456292	5456292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5456292C>T	ENST00000222033.4	+	1	867	c.790C>T	c.(790-792)Ctg>Ttg	p.L264L		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	264						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		TACCCTGGCCCTGGTCGTATC	0.677000													27	71					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167645876	167645876	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167645876C>T	ENST00000519204.1	+	22	4735	c.4617C>T	c.(4615-4617)acC>acT	p.T1539T	TENM2_ENST00000545108.1_Silent_p.T1659T|TENM2_ENST00000518659.1_Silent_p.T1660T|TENM2_ENST00000520394.1_Silent_p.T1421T|TENM2_ENST00000403607.2_Silent_p.T1484T					teneurin transmembrane protein 2																		TCACCCTCACCGTGGGCACCA	0.552000													29	141					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231115757	231115757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231115757C>T	ENST00000392045.3	+	10	1152	c.1038C>T	c.(1036-1038)tcC>tcT	p.S346S	SP140_ENST00000417495.3_Intron|SP140_ENST00000486687.2_Silent_p.S270S|SP140_ENST00000420434.3_Silent_p.S346S|SP140_ENST00000350136.5_Intron|SP140_ENST00000343805.6_Silent_p.S320S	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	346					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CCTCTAGCTCCCTAGCAAGAT	0.478000													19	43					0	0	1	0	0
SUSD4	55061	broad.mit.edu	37	1	223465938	223465938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:223465938C>T	ENST00000343846.3	-	2	837	c.204G>A	c.(202-204)agG>agA	p.R68R	SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000454695.2_5'UTR|SUSD4_ENST00000344029.6_Silent_p.R68R|SUSD4_ENST00000366878.4_Silent_p.R68R			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	68	Sushi 1.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		CGCTGGGGGTCCTGAAGCCAT	0.507000													25	80					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595094	179595094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179595094G>A	ENST00000589042.1	-	62	18257	c.18033C>T	c.(18031-18033)ccC>ccT	p.P6011P	TTN_ENST00000342992.6_Silent_p.P4767P|TTN_ENST00000591111.1_Silent_p.P5694P|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5694	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAAGTAAGGGGGTTCTGAGG	0.353000													6	16					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16925942	16925942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16925942G>A	ENST00000552788.1	+	18	4497	c.4497G>A	c.(4495-4497)gaG>gaA	p.E1499E	NWD1_ENST00000523826.1_Silent_p.E1293E|NWD1_ENST00000379808.3_3'UTR|NWD1_ENST00000524140.2_3'UTR|NWD1_ENST00000339803.6_Silent_p.E1364E|NWD1_ENST00000549814.1_Silent_p.E1457E			Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1499							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGATCCGAGAGAATTTCCAGT	0.512000													31	66					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427393	119427393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119427393G>A	ENST00000369429.3	-	8	1780	c.1771C>T	c.(1771-1773)Cca>Tca	p.P591S	TBX15_ENST00000207157.3_Missense_Mutation_p.P485S			Q96SF7	TBX15_HUMAN	T-box 15	591						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GAGGAGCCTGGAACTGCCCCA	0.557000													29	88					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190805	209190805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:209190805C>T	ENST00000264380.4	+	20	3428	c.3270C>T	c.(3268-3270)ctC>ctT	p.L1090L		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1090					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						GGTCTCCTCTCCTCAATAAAG	0.448000													27	84					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124626255	124626255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124626255G>A	ENST00000278927.5	-	4	584	c.455C>T	c.(454-456)cCt>cTt	p.P152L	ESAM_ENST00000442070.2_Intron	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	152					blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		AGGAGCTGGAGGAACTGGGCA	0.597000													3	12					0	0	1	0	0
PROZ	8858	broad.mit.edu	37	13	113814419	113814419	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113814419G>A	ENST00000342783.4	+	3	235	c.228G>A	c.(226-228)ttG>ttA	p.L76L	PROZ_ENST00000375547.2_Silent_p.L54L	NM_001256134.1	NP_001243063.1	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma glycoprotein	54	Gla.				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity			NS(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(4)|prostate(2)|skin(2)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	AGGGAAACTTGGAAAAAGAAT	0.463000													68	167					0	0	1	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129042	248129042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248129042C>T	ENST00000366480.3	+	1	508	c.409C>T	c.(409-411)Cgc>Tgc	p.R137C	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTCTTATGATCGCTATGTAGC	0.438000													111	318					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167077760	167077760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167077760C>T	ENST00000392766.2	-	8	670	c.330G>A	c.(328-330)gtG>gtA	p.V110V	ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Silent_p.V81V|ZBBX_ENST00000455345.2_Silent_p.V110V|ZBBX_ENST00000392767.2_Silent_p.V110V|ZBBX_ENST00000307529.5_Silent_p.V110V	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	110						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CTGTTGGTTTCACTGGCTCTG	0.303000													17	37					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161007493	161007493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161007493G>A	ENST00000447678.1	-	26	4237	c.4117C>T	c.(4117-4119)Cct>Tct	p.P1373S	LPA_ENST00000316300.5_Missense_Mutation_p.P1373S	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3881	Kringle 12.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TCTTCAGAAGGAAGCTCTGTG	0.478000													36	45					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184103898	184103898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184103898C>T	ENST00000204604.1	+	15	2129	c.1883C>T	c.(1882-1884)tCc>tTc	p.S628F	EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000545352.1_Missense_Mutation_p.S258F|CHRD_ENST00000348986.3_Missense_Mutation_p.S588F|CHRD_ENST00000450923.1_Missense_Mutation_p.S628F	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	628	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCATGGCCTCCCTGATGATC	0.622000													29	76					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167814888	167814888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167814888G>A	ENST00000367848.1	-	21	3141	c.2644C>T	c.(2644-2646)Ccc>Tcc	p.P882S	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Missense_Mutation_p.P974S|ADCY10_ENST00000545172.1_Missense_Mutation_p.P821S			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	974					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TGATGATAGGGAATGAAGTCC	0.448000													33	68					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120871407	120871407	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120871407G>A	ENST00000273666.6	+	8	1024	c.753_splice	c.e8+1	p.E251_splice	STXBP5L_ENST00000471454.1_Splice_Site_p.E251_splice|STXBP5L_ENST00000492541.1_Splice_Site_p.E251_splice|STXBP5L_ENST00000497029.1_Splice_Site_p.E251_splice|STXBP5L_ENST00000472879.1_Splice_Site_p.E251_splice	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	251					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ATTATGATGAGGTAAGTGATT	0.353000													27	54					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82763915	82763915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82763915C>T	ENST00000423517.2	-	3	3288	c.2951G>A	c.(2950-2952)gGt>gAt	p.G984D	PCLO_ENST00000333891.8_Missense_Mutation_p.G984D	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	930					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGTGCTTGACCTGTGGATTT	0.512000													21	33					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123193527	123193527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123193527C>T	ENST00000264501.4	+	48	8786	c.8413C>T	c.(8413-8415)Cat>Tat	p.H2805Y	KIAA1109_ENST00000388738.3_Missense_Mutation_p.H2805Y|KIAA1109_ENST00000455637.1_Missense_Mutation_p.H2805Y			Q2LD37	K1109_HUMAN	KIAA1109	2805					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GAAGAGGATCCATGGCAGTTT	0.363000													18	56					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88584297	88584297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88584297C>T	ENST00000339673.6	+	6	1466	c.1367C>T	c.(1366-1368)tCt>tTt	p.S456F	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.S440F|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	456					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GACAGTGACTCTCAAGACAGC	0.522000													16	59					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141765585	141765585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141765585G>A	ENST00000475668.2	+	40	4778	c.4724G>A	c.(4723-4725)gGg>gAg	p.G1575E	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1575	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ATGCAGCTGGGGGCCTTTTAC	0.493000													18	44					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57478841	57478841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57478841C>T	ENST00000371100.4	+	5	2908	c.2356C>T	c.(2356-2358)Cct>Tct	p.P786S	GNAS_ENST00000306090.10_Missense_Mutation_p.P129S|GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000265620.7_Missense_Mutation_p.P128S|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371102.4_Missense_Mutation_p.P772S|GNAS_ENST00000354359.7_Missense_Mutation_p.P144S|GNAS_ENST00000313949.7_3'UTR|GNAS_ENST00000371095.3_Missense_Mutation_p.P129S|GNAS_ENST00000371085.3_Missense_Mutation_p.P143S	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	143					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CTTTGACTTCCCTCCCGTAAG	0.582000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			53	216					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109881406	109881406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109881406G>A	ENST00000310903.5	+	28	2834	c.2728G>A	c.(2728-2730)Gtg>Atg	p.V910M	MYO1H_ENST00000431443.2_Missense_Mutation_p.V920M			B4DNW6	B4DNW6_HUMAN	myosin IH	101						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						AGCTTACGTGGTGGAACTTGC	0.443000													10	20					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24561588	24561588	+	Silent	SNP	C	C	T	rs150284461		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24561588C>T	ENST00000398319.2	+	31	5386	c.5001C>T	c.(4999-5001)ctC>ctT	p.L1667L	CABIN1_ENST00000405822.2_Silent_p.L1588L|CABIN1_ENST00000263119.5_Silent_p.L1667L|CABIN1_ENST00000337989.7_Silent_p.L92L	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1667					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TGAGCGAGCTCGCAGAGGTAT	0.612000													8	20					0	0	1	0	0
FHL5	9457	broad.mit.edu	37	6	97058463	97058463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:97058463G>A	ENST00000326771.2	+	6	900	c.520G>A	c.(520-522)Ggg>Agg	p.G174R	FHL5_ENST00000541107.1_Missense_Mutation_p.G174R	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	174	LIM zinc-binding 3.					nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		AACTTCAGGTGGGATAACATT	0.413000													64	103					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39798511	39798511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39798511C>T	ENST00000248668.4	-	2	2077	c.2078G>A	c.(2077-2079)gGa>gAa	p.G693E		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	693						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGCCGCGGCTCCCCCAGGAAC	0.721000													5	9					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17198950	17198950	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17198950C>T	ENST00000180173.5	-	6	688	c.654G>A	c.(652-654)gaG>gaA	p.E218E	MTMR7_ENST00000521857.1_Silent_p.E218E|MTMR7_ENST00000523571.1_5'UTR	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	218	Myotubularin phosphatase.						protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		TCTGCTCGTCCTCTAGGCACC	0.577000													7	40					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111570421	111570421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:111570421G>A	ENST00000261486.5	-	12	1273	c.997C>T	c.(997-999)Ctt>Ttt	p.L333F	RP11-526F3.1_ENST00000504004.1_RNA	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	333						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TGAATAGAAAGATCTCGGCTC	0.443000													52	121					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64756126	64756126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:64756126C>T	ENST00000536360.1	-	4	1315	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	168					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TTTAAAGGTTCGATAAAATAC	0.313000													22	128					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119923749	119923749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119923749G>A	ENST00000361035.4	+	3	363	c.80G>A	c.(79-81)cGa>cAa	p.R27Q	HAO2_ENST00000325945.3_Missense_Mutation_p.R14Q	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	14	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity	p.R14L(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		GCCCATGCGCGAGAGCAGCTG	0.468000													63	154					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185229332	185229332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185229332C>T	ENST00000296252.4	-	9	1389	c.1248G>A	c.(1246-1248)agG>agA	p.R416R	LIPH_ENST00000424591.2_Silent_p.R382R	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	416					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GGGCAAGGGACCTTAACTTCA	0.468000													34	69					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77327083	77327083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77327083G>A	ENST00000282849.5	-	20	3497	c.3079C>T	c.(3079-3081)Ccc>Tcc	p.P1027S		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	1027	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGGCTCTCGGGGAGGGTTTCT	0.572000													46	86					0	0	1	0	0
ODF3L2	284451	broad.mit.edu	37	19	474630	474630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:474630G>A	ENST00000315489.4	-	1	353	c.118C>T	c.(118-120)Ctg>Ttg	p.L40L	ODF3L2_ENST00000382696.3_Silent_p.L40L	NM_182577.2	NP_872383.1	Q3SX64	OD3L2_HUMAN	outer dense fiber of sperm tails 3-like 2	40										large_intestine(1)|lung(2)	3						CCGTTCTCCAGGGTGGCCGTC	0.672000													5	12					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127768553	127768553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:127768553C>T	ENST00000483725.3	-	5	1247	c.911G>A	c.(910-912)cGa>cAa	p.R304Q	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	304							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		CCTTTTACTTCGACCCTCATG	0.433000													53	40					0	0	1	0	0
DDX41	51428	broad.mit.edu	37	5	176939611	176939611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176939611G>A	ENST00000507955.1	-	14	1958	c.1435C>T	c.(1435-1437)Cgg>Tgg	p.R479W		NM_016222.2	NP_057306.2	Q9UJV9	DDX41_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	479	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TTGCCCTCCCGGAATGCCTCG	0.597000													5	77					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95380460	95380460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95380460C>T	ENST00000371447.3	+	2	690	c.552C>T	c.(550-552)atC>atT	p.I184I		NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	184	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				CAACCCCGATCGTGGTGGGCA	0.443000													33	84					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93797595	93797595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93797595G>A	ENST00000315765.9	+	4	735	c.727G>A	c.(727-729)Gaa>Aaa	p.E243K		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	243	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GTACCTCAATGAAAATATCAA	0.398000													16	39					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17013509	17013509	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17013509C>T	ENST00000443236.1	-	35	4807	c.4776G>A	c.(4774-4776)gcG>gcA	p.A1592A		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1545						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GCTGATCGGCCGCTGGGTCAT	0.662000													11	41					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178410064	178410064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178410064G>A	ENST00000231188.5	-	9	2461	c.2283C>T	c.(2281-2283)ctC>ctT	p.L761L	GRM6_ENST00000517717.1_Silent_p.L761L|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	761					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		ACGTGACCATGAGCAGGAGGC	0.622000													24	74					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36884182	36884182	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36884182G>A	ENST00000301807.6	-	17	5326	c.3429C>T	c.(3427-3429)ttC>ttT	p.F1143F	TRANK1_ENST00000429976.2_Silent_p.F1693F|TRANK1_ENST00000463984.1_5'UTR|TRANK1_ENST00000428977.2_Silent_p.F1143F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1693					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGGTCTTAACGAACATGCTAT	0.463000													28	12					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145427402	145427402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145427402C>T	ENST00000511217.1	+	5	1179	c.1127C>T	c.(1126-1128)tCc>tTc	p.S376F	SH3RF2_ENST00000359120.4_Missense_Mutation_p.S376F			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	376							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGCCTGGCTCCCAGCAACAC	0.537000													20	54					0	0	1	0	0
CD247	919	broad.mit.edu	37	1	167487664	167487664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167487664C>T	ENST00000392122.3	-	1	183	c.39G>A	c.(37-39)caG>caA	p.Q13Q	CD247_ENST00000362089.5_Silent_p.Q13Q|CD247_ENST00000483825.1_5'UTR	NM_000734.3|NM_198053.2	NP_000725.1|NP_932170.1	P20963	CD3Z_HUMAN	CD247 molecule	13					interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(543;0.236)			GCAACTGTGCCTGCAGGATGG	0.597000													6	71					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120349057	120349057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120349057C>T	ENST00000397843.2	+	37	3891	c.3725C>T	c.(3724-3726)cCt>cTt	p.P1242L	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.P1223L|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.P1139L	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1242					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TCACACCTGCCTGTCTCAGAA	0.398000			T	MLL	AML								35	73					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78433820	78433820	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78433820G>A	ENST00000278550.7	-	24	4155	c.3693C>T	c.(3691-3693)gcC>gcT	p.A1231A		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GGGCCACTGGGGCCAGGAGCT	0.577000													11	90					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65180988	65180988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:65180988G>A	ENST00000310045.7	-	2	2361	c.888C>T	c.(886-888)tcC>tcT	p.S296S	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	286						integral to membrane	isomerase activity|sulfotransferase activity	p.S296S(1)		NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				ACTGTGTGACGGATTTAGCTG	0.388000													53	90					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35366948	35366948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35366948C>T	ENST00000378495.3	+	11	1394	c.1172C>T	c.(1171-1173)cCa>cTa	p.P391L	UNC13B_ENST00000396787.1_Missense_Mutation_p.P403L|UNC13B_ENST00000378496.4_Missense_Mutation_p.P391L	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	391					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TTAAAGATTCCAGATGATGGT	0.448000													12	55					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47299583	47299583	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47299583G>A	ENST00000225941.1	+	7	1431	c.933G>A	c.(931-933)gaG>gaA	p.E311E	ABI3_ENST00000419580.2_Silent_p.E305E	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	311	SH3.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			CATACTTGGAGAAAGGTACCT	0.592000										HNSCC(55;0.14)			27	73					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926778	130926778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130926778C>T	ENST00000261655.4	-	8	1231	c.1068G>A	c.(1066-1068)aaG>aaA	p.K356K	RIMBP2_ENST00000536002.1_Silent_p.K264K|RIMBP2_ENST00000535703.1_Silent_p.K264K	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	356	Fibronectin type-III 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CCATGTTGAGCTTCTCGATGA	0.612000													26	63					0	0	1	0	0
FAM74A3	728495	broad.mit.edu	37	9	40715848	40715848	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:40715848G>A	ENST00000604146.1	+	0	187					NR_026801.1															endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACCCAGAGAAGATGTGGAGGG	0.567000													3	3					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954625	70954625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70954625C>T	ENST00000393567.2	-	46	7804	c.7654G>A	c.(7654-7656)Ggg>Agg	p.G2552R		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2552										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				tcctcctccccttccccctcc	0.647000													3	7					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575497	136575497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136575497C>T	ENST00000264162.2	-	6	1131	c.1121G>A	c.(1120-1122)aGg>aAg	p.R374K		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	374	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAAGGCATCCCTTTCCGCCCT	0.602000													47	135					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138453099	138453099	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138453099T>C	ENST00000344876.4	-	1	530	c.144A>G	c.(142-144)tcA>tcG	p.S48S	PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000412923.2_Silent_p.S48S|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	48	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S48S(1)		NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					CCACATCCTCTGATAGTCTTG	0.413000													33	85					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124757009	124757009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124757009G>A	ENST00000306534.3	-	15	2784	c.2299C>T	c.(2299-2301)Ctc>Ttc	p.L767F	ROBO4_ENST00000533054.1_Missense_Mutation_p.L622F|RP11-664I21.5_ENST00000524453.1_RNA	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	767	Pro/Ser-rich.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGGCCAGAGAGGGAAGAGGCC	0.672000													11	47					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247582117	247582117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247582117C>T	ENST00000366497.2	+	2	801	c.21C>T	c.(19-21)cgC>cgT	p.R7R	NLRP3_ENST00000391828.3_Silent_p.R7R|NLRP3_ENST00000336119.3_Silent_p.R7R|NLRP3_ENST00000391827.2_Silent_p.R7R|NLRP3_ENST00000348069.2_Silent_p.R7R|NLRP3_ENST00000366496.2_Silent_p.R7R|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	7	DAPIN.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAAGCACCCGCTGCAAGCTGG	0.537000													13	44					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70007795	70007795	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70007795G>A	ENST00000355303.5	+	18	2153	c.1848G>A	c.(1846-1848)gtG>gtA	p.V616V	ANO1_ENST00000398543.2_Silent_p.V470V|ANO1_ENST00000538023.1_Silent_p.V616V|ANO1_ENST00000530676.1_Silent_p.V470V|ANO1_ENST00000531349.1_Silent_p.V325V|ANO1_ENST00000316296.5_Silent_p.V558V	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	616					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TGAAGTTTGTGAATTCCTACA	0.532000													44	139					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128362828	128362828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128362828G>A	ENST00000262462.4	+	7	2268	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	SLC27A6_ENST00000506176.1_Missense_Mutation_p.E420K|SLC27A6_ENST00000395266.1_Missense_Mutation_p.E420K			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	420					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TCTTGCAGGAGAACCTGGACT	0.383000													37	84					0	0	1	0	0
KLRC4	8302	broad.mit.edu	37	12	10560278	10560278	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10560278G>A	ENST00000309384.1	-	4	632	c.451C>T	c.(451-453)Cga>Tga	p.R151*	KLRC4-KLRK1_ENST00000539300.1_Missense_Mutation_p.S142L	NM_013431.2	NP_038459.1	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C, member 4	151					cellular defense response	integral to membrane	binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	5						AGAGTTCTTCGAAGCACAGGC	0.363000													92	215					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170498183	170498183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:170498183G>A	ENST00000439128.2	-	11	1556	c.916C>T	c.(916-918)Cag>Tag	p.Q306*	NEK1_ENST00000510533.1_Nonsense_Mutation_p.Q306*|NEK1_ENST00000512193.1_Nonsense_Mutation_p.Q306*|NEK1_ENST00000511633.1_Nonsense_Mutation_p.Q306*|NEK1_ENST00000507142.1_Nonsense_Mutation_p.Q306*	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	306					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		GTAATTTTCTGAGCAGGCATA	0.328000													17	41					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117922301	117922301	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117922301C>T	ENST00000425217.1	-	16	2337	c.2283G>A	c.(2281-2283)aaG>aaA	p.K761K	KSR2_ENST00000302438.5_3'UTR|KSR2_ENST00000339824.5_Silent_p.K790K	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	790	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGAAGACGTTCTTTGACTTGA	0.527000													10	27					0	0	1	0	0
C1orf158	93190	broad.mit.edu	37	1	12815753	12815753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12815753G>A	ENST00000288048.5	+	2	431	c.215G>A	c.(214-216)aGg>aAg	p.R72K	C1orf158_ENST00000376210.3_Intron	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	72										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TATGGGAAGAGGAAAGTTGAG	0.527000													18	36					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413453	72413453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72413453C>T	ENST00000395270.1	+	14	3167	c.2126C>T	c.(2125-2127)gCc>gTc	p.A709V	POM121_ENST00000358357.3_Missense_Mutation_p.A709V|POM121_ENST00000257622.4_Missense_Mutation_p.A709V|POM121_ENST00000446813.1_Missense_Mutation_p.A709V|POM121_ENST00000434423.2_Missense_Mutation_p.A974V	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	974	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				GCATTTGGGGCCGCTGAGGGG	0.652000													17	53					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36945041	36945041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36945041G>A	ENST00000373103.1	-	3	604	c.57C>T	c.(55-57)ctC>ctT	p.L19L	CSF3R_ENST00000338937.5_Silent_p.L19L|CSF3R_ENST00000373106.1_Silent_p.L19L|CSF3R_ENST00000361632.4_Silent_p.L19L|CSF3R_ENST00000373104.1_Silent_p.L19L|CSF3R_ENST00000440588.2_Silent_p.L19L|CSF3R_ENST00000418048.2_Silent_p.L19L|CSF3R_ENST00000331941.5_Silent_p.L19L	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	19					cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CACTTCCGGGGAGCAGCAGGA	0.547000													20	50					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31914248	31914248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31914248G>A	ENST00000456570.1	+	14	1724	c.1669G>A	c.(1669-1671)Ggc>Agc	p.G557S	CFB_ENST00000425368.2_Missense_Mutation_p.G55S|CFB_ENST00000477310.1_Intron|CFB_ENST00000556679.1_Missense_Mutation_p.G557S			P00751	CFAB_HUMAN	complement factor B	55	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TCTCCAAGAGGGCCAGGCACT	0.602000													28	61					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54850343	54850343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54850343G>A	ENST00000291759.4	-	1	78	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	8						integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		AAGAAGAGCAGGCTTGTGAGA	0.562000													5	89					0	0	1	0	0
CD38	952	broad.mit.edu	37	4	15826536	15826536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:15826536C>T	ENST00000226279.2	+	3	533	c.396C>T	c.(394-396)gcC>gcT	p.A132A		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	132					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						AAGATCTGGCCCATCAGTTCA	0.418000													18	76					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22182404	22182404	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22182404G>A	ENST00000374695.3	-	45	5656	c.5575_splice	c.e45-1	p.A1859_splice		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1859	Ig-like C2-type 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGGTGCCCGAGGCTGACAAGG	0.632000													15	33					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138745818	138745818	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138745818G>T	ENST00000242351.5	-	9	2376	c.2060C>A	c.(2059-2061)cCt>cAt	p.P687H	ZC3HAV1_ENST00000471652.1_Missense_Mutation_p.P687H|ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.P809H	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	687					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						ATACCACTGAGGCACAAATGT	0.433000													19	172					1.96292e-10	1.97069e-10	1	1	0
SLC44A3	126969	broad.mit.edu	37	1	95290159	95290159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:95290159C>T	ENST00000271227.6	+	3	348	c.246C>T	c.(244-246)gcC>gcT	p.A82A	SLC44A3_ENST00000467909.1_Silent_p.A34A|SLC44A3_ENST00000532427.1_Silent_p.A34A|SLC44A3_ENST00000529450.1_Silent_p.A82A|SLC44A3_ENST00000527077.1_Silent_p.A46A|SLC44A3_ENST00000446120.2_Silent_p.A46A	NM_001114106.2|NM_001258340.1|NM_001258341.1	NP_001107578.1|NP_001245269.1|NP_001245270.1	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3	82						integral to membrane|plasma membrane	choline transmembrane transporter activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|prostate(2)|stomach(1)|urinary_tract(1)	23		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	TGGAAGGGGCCCCTCTTTCAG	0.488000													19	124					0	0	1	0	0
IKBKE	9641	broad.mit.edu	37	1	206653844	206653844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206653844C>T	ENST00000367120.3	+	13	1768	c.1395C>T	c.(1393-1395)ctC>ctT	p.L465L	IKBKE_ENST00000462698.1_3'UTR|IKBKE_ENST00000537984.1_Silent_p.L380L	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	465					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					GGACATCCCTCCTCTACCTCA	0.612000													9	21					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187535466	187535466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187535466G>A	ENST00000441802.2	-	12	9317	c.9108C>T	c.(9106-9108)gtC>gtT	p.V3036V		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3036	Cadherin 28.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTCCAGGAAGGACGTCTTCAG	0.388000										HNSCC(5;0.00058)			28	58					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479481	156479481	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156479481C>T	ENST00000339252.3	-	3	1096	c.564G>A	c.(562-564)acG>acA	p.T188T	HAVCR1_ENST00000544197.1_Silent_p.T188T|HAVCR1_ENST00000523175.1_Silent_p.T188T|HAVCR1_ENST00000425854.1_Silent_p.T188T|HAVCR1_ENST00000522693.1_Silent_p.T188T	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	183	11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].|Thr-rich.				interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGGAACGCTCGTTGTCGTTG	0.473000													171	448					0	0	1	0	0
EXOSC7	23016	broad.mit.edu	37	3	45030635	45030635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45030635G>A	ENST00000265564.7	+	2	109	c.61G>A	c.(61-63)Gac>Aac	p.D21N	EXOSC7_ENST00000461361.1_3'UTR	NM_015004.3	NP_055819.2	Q15024	EXOS7_HUMAN	exosome component 7	21					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding			endometrium(3)|large_intestine(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		CACCTAGGAAGACCTCCGTGT	0.507000													11	35					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130919328	130919328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130919328C>T	ENST00000261655.4	-	11	2316	c.2153G>A	c.(2152-2154)aGg>aAg	p.R718K	RIMBP2_ENST00000536002.1_Missense_Mutation_p.R626K|RIMBP2_ENST00000535703.1_Missense_Mutation_p.R626K	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	718						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CGAGGCGCCCCTCCTCTTGAA	0.627000													54	81					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175063304	175063304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175063304G>A	ENST00000239462.4	+	7	1616	c.1503G>A	c.(1501-1503)ctG>ctA	p.L501L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	501	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGACGGGCCTGAAGCCAGGAG	0.547000													18	34					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	328088	328088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:328088C>T	ENST00000432829.2	+	9	1073	c.757C>T	c.(757-759)Cct>Tct	p.P253S	DOCK8_ENST00000453981.1_Missense_Mutation_p.P321S|DOCK8_ENST00000469391.1_Missense_Mutation_p.P253S	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	321					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AGCTCACACGCCTTCAGTGGC	0.458000													7	59					0	0	1	0	0
GREM2	64388	broad.mit.edu	37	1	240656745	240656745	+	Silent	SNP	G	G	A	rs17857321		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240656745G>A	ENST00000318160.4	-	2	297	c.31C>T	c.(31-33)Ctg>Ttg	p.L11L		NM_022469.3	NP_071914.3	Q9H772	GREM2_HUMAN	gremlin 2, DAN family BMP antagonist	11				L -> M (in Ref. 3; AAH46632).	BMP signaling pathway	extracellular space	cytokine activity			endometrium(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	10		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			ACCGCCACCAGGAACAAGGAC	0.582000													3	15					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198949941	198949941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:198949941G>A	ENST00000428675.1	+	2	2098	c.1700G>A	c.(1699-1701)aGg>aAg	p.R567K	PLCL1_ENST00000437704.2_Missense_Mutation_p.R469K	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	567	Interaction with GABA A beta subunit (By similarity).				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	ATGTCTCGAAGGATGTCGGTA	0.393000													28	92					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153030042	153030042	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153030042G>A	ENST00000285900.5	+	4	956	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K	GRIA1_ENST00000518142.1_Missense_Mutation_p.E125K|GRIA1_ENST00000518862.1_3'UTR|GRIA1_ENST00000518783.1_Missense_Mutation_p.E215K|GRIA1_ENST00000521843.2_Missense_Mutation_p.E136K|GRIA1_ENST00000448073.4_Missense_Mutation_p.E215K|GRIA1_ENST00000340592.5_Missense_Mutation_p.E205K	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	205					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGTGGACTGTGAATCAGAACG	0.532000													17	47					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111398054	111398054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111398054G>A	ENST00000265162.5	+	1	826	c.484G>A	c.(484-486)Gag>Aag	p.E162K		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	162					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GAGGTGTTTCGAGTACAAAAA	0.627000													54	142					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34040696	34040696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34040696G>A	ENST00000389232.4	+	55	8234	c.8164G>A	c.(8164-8166)Gac>Aac	p.D2722N	RYR3_ENST00000415757.3_Missense_Mutation_p.D2722N	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2722	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGCTCCCCTCGACCTCTCAAA	0.517000													9	17					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231373	21231373	+	Silent	SNP	G	G	A	rs149734450		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21231373G>A	ENST00000233242.1	-	26	8494	c.8367C>T	c.(8365-8367)atC>atT	p.I2789I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2789					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGAAGCTGCGATACCTGCTT	0.413000													66	121					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33597733	33597733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33597733C>T	ENST00000170564.2	+	10	1527	c.1213C>T	c.(1213-1215)Cca>Tca	p.P405S		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	405						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					AACGCCTGACCCAGGGACACA	0.522000													13	69					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31917963	31917963	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:31917963G>A	ENST00000396556.2	-	3	621	c.499C>T	c.(499-501)Cga>Tga	p.R167*	OSBPL10_ENST00000438237.2_Nonsense_Mutation_p.R167*	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	167	PH.				lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		GCACAAGCTCGAAGCTGAGTC	0.418000													21	45					0	0	1	0	0
PNP	4860	broad.mit.edu	37	14	20943236	20943236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20943236C>T	ENST00000361505.5	+	5	623	c.477C>T	c.(475-477)ttC>ttT	p.F159F	RP11-203M5.8_ENST00000554678.1_lincRNA	NM_000270.3	NP_000261.2	P00491	PNPH_HUMAN	purine nucleoside phosphorylase	159					immune response|inosine catabolic process|interleukin-2 secretion|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide riboside catabolic process|positive regulation of alpha-beta T cell differentiation|positive regulation of T cell proliferation|purine base metabolic process|purine nucleotide catabolic process|purine-containing compound salvage|response to drug|urate biosynthetic process	cytoskeleton|cytosol	drug binding|nucleoside binding|phosphate binding|purine base binding|purine-nucleoside phosphorylase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|stomach(2)	10					Aciclovir(DB00787)|Cladribine(DB00242)|Mercaptopurine(DB01033)	GAGATCGTTTCCCTGCCATGT	0.473000													18	36					0	0	1	0	0
FAM129C	199786	broad.mit.edu	37	19	17660315	17660315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17660315C>T	ENST00000335393.4	+	15	1960	c.1822C>T	c.(1822-1824)Cca>Tca	p.P608S	FAM129C_ENST00000599164.1_Missense_Mutation_p.P577S|FAM129C_ENST00000332386.5_Missense_Mutation_p.P608S|FAM129C_ENST00000599124.1_Missense_Mutation_p.P541S|FAM129C_ENST00000601861.1_Missense_Mutation_p.P577S|FAM129C_ENST00000595684.1_Missense_Mutation_p.P608S|FAM129C_ENST00000449408.2_Missense_Mutation_p.P334S|FAM129C_ENST00000600871.1_Intron|FAM129C_ENST00000352727.3_Missense_Mutation_p.P572S	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	608										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						CTTGGAGGTCCCATGGGAACA	0.552000													32	108					0	0	1	0	0
MIR422A	494334	broad.mit.edu	37	15	64163163	64163163	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:64163163G>A	ENST00000362286.1	-	0	55					NR_029944.1																						gggacagagagcccatctgca	0.547000													8	143					0	0	1	0	0
MGLL	11343	broad.mit.edu	37	3	127454584	127454584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127454584C>T	ENST00000398101.3	-	1	616	c.118G>A	c.(118-120)Ggg>Agg	p.G40R	MGLL_ENST00000434178.2_Intron|MGLL_ENST00000453507.2_Intron|MGLL_ENST00000398104.1_Intron|MGLL_ENST00000265052.5_Intron			Q99685	MGLL_HUMAN	monoglyceride lipase	0					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6						TGCTCGCTCCCCGCCTTCTCC	0.493000													35	108					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113138932	113138932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113138932G>A	ENST00000393845.2	-	5	568	c.502C>T	c.(502-504)Ctg>Ttg	p.L168L	WDR52-AS1_ENST00000498480.1_RNA|WDR52_ENST00000295868.2_Silent_p.L168L|WDR52-AS1_ENST00000473329.1_RNA	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	168										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						TTCAAATTCAGAAAGATCAGT	0.428000													10	41					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032327	30032327	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30032327C>T	ENST00000328224.6	-	2	3132	c.1899G>A	c.(1897-1899)ggG>ggA	p.G633G		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	633						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CACTGTCATCCCCCTTTCCCT	0.478000													31	135					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39903468	39903468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:39903468C>T	ENST00000564288.1	+	71	18785	c.18008C>T	c.(18007-18009)cCt>cTt	p.P6003L	MACF1_ENST00000289893.4_Missense_Mutation_p.P4446L|MACF1_ENST00000545844.1_Missense_Mutation_p.P3944L|MACF1_ENST00000539005.1_Missense_Mutation_p.P3814L|MACF1_ENST00000372915.3_Missense_Mutation_p.P5902L|MACF1_ENST00000361689.2_Missense_Mutation_p.P3944L|MACF1_ENST00000317713.7_Missense_Mutation_p.P3944L|MACF1_ENST00000567887.1_Missense_Mutation_p.P6040L			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	6015					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAAATTGAGCCTATGTTGGAG	0.423000													41	118					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72862289	72862289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72862289G>A	ENST00000455107.2	-	6	755	c.339C>T	c.(337-339)ttC>ttT	p.F113F	FDXR_ENST00000581530.1_Silent_p.F157F|FDXR_ENST00000413947.2_Silent_p.F188F|FDXR_ENST00000293195.5_Silent_p.F157F|FDXR_ENST00000544854.1_Silent_p.F105F|FDXR_ENST00000581969.1_5'UTR|FDXR_ENST00000420580.2_Silent_p.F117F|FDXR_ENST00000442102.2_Silent_p.F200F|FDXR_ENST00000582944.1_Silent_p.F149F|FDXR_ENST00000583917.1_Silent_p.F158F			P22570	ADRO_HUMAN	ferredoxin reductase	157					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					ACCAGCCCACGAAGGCCCGGG	0.652000													11	114					0	0	1	0	0
GPT2	84706	broad.mit.edu	37	16	46943652	46943652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:46943652C>T	ENST00000440783.2	+	6	998	c.333C>T	c.(331-333)atC>atT	p.I111I	GPT2_ENST00000340124.4_Silent_p.I211I	NM_001142466.1	NP_001135938.1	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase (alanine aminotransferase) 2	211					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding	p.I211I(1)		NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GTGTGATGATCCCCATCCCAC	0.537000													23	73					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35832298	35832298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35832298C>T	ENST00000085219.5	+	8	1626	c.1560C>T	c.(1558-1560)caC>caT	p.H520H	CD22_ENST00000536635.2_Silent_p.H432H|CD22_ENST00000270311.6_Silent_p.H400H|CD22_ENST00000544992.2_Silent_p.H520H|CD22_ENST00000594250.1_Silent_p.H343H|CD22_ENST00000419549.2_Silent_p.H348H|CD22_ENST00000341773.6_Silent_p.H343H	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	520	Ig-like C2-type 5.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CCGAGATTCACTCTGGAAACT	0.552000													29	43					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106924104	106924104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106924104C>T	ENST00000369701.3	+	12	2003	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	592						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TTGGTGTGTTCATCTCCTCCG	0.438000													24	49					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385622	33385622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33385622G>A	ENST00000541274.1	-	5	822	c.373C>T	c.(373-375)Cct>Tct	p.P125S	AQP7_ENST00000377425.4_Intron|AQP7_ENST00000537089.1_Silent_p.F164F|AQP7_ENST00000539936.1_Silent_p.F256F			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		AAACTCAAAGGAATGGGCCTG	0.627000													18	67					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19483433	19483433	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19483433G>A	ENST00000396229.2	+	11	2555	c.1806G>A	c.(1804-1806)caG>caA	p.Q602Q	TMC5_ENST00000219821.5_Silent_p.Q356Q|TMC5_ENST00000542583.2_Silent_p.Q602Q|TMC5_ENST00000541464.1_Intron|TMC5_ENST00000381414.4_Silent_p.Q602Q|TMC5_ENST00000561503.1_Silent_p.Q243Q|TMC5_ENST00000564959.1_Silent_p.Q285Q	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	602						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AGCTCCGTCAGGAGAATTCCA	0.527000													24	110					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95670166	95670166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95670166G>A	ENST00000298912.4	-	9	1633	c.1520C>T	c.(1519-1521)tCc>tTc	p.S507F		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	507						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		ACCATTACAGGAAGAAGACTG	0.468000													15	44					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56138249	56138249	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56138249G>A	ENST00000319441.4	+	5	940	c.776G>A	c.(775-777)gGg>gAg	p.G259E	PCK1_ENST00000543666.1_Intron|PCK1_ENST00000535860.1_Missense_Mutation_p.G127E	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	259					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			AAGGAGGAAGGGTGGCTGGCA	0.597000													32	64					0	0	1	0	0
SLC25A12	8604	broad.mit.edu	37	2	172644360	172644360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:172644360G>A	ENST00000422440.2	-	16	1720	c.1683C>T	c.(1681-1683)atC>atT	p.I561I	SLC25A12_ENST00000392592.4_Silent_p.I454I	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	561					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	TGAAACAGTCGATGACACCAC	0.577000													25	58					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76472668	76472668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:76472668C>T	ENST00000396423.2	+	9	1307	c.1183C>T	c.(1183-1185)Ccc>Tcc	p.P395S	HNF4G_ENST00000354370.1_Missense_Mutation_p.P358S	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	358					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ACTTTTAGGTCCCATGTCAAC	0.393000													11	42					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976196	20976196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20976196C>T	ENST00000261383.3	-	53	9009	c.9010G>A	c.(9010-9012)Gga>Aga	p.G3004R	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3004					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCCACAGTTCCTGAGGACAGC	0.537000													23	58					0	0	1	0	0
CDKN2AIP	55602	broad.mit.edu	37	4	184366211	184366211	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:184366211C>T	ENST00000504169.1	+	1	468	c.261C>T	c.(259-261)ttC>ttT	p.F87F	CDKN2AIP_ENST00000302350.4_Silent_p.F87F|CDKN2AIP_ENST00000510928.1_Silent_p.F87F	NM_017632.2	NP_060102.1	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	87					negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(1)	6		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		ACCACGTCTTCCTCGGGTGCC	0.687000													30	77					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115439652	115439652	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:115439652G>A	ENST00000393780.3	+	4	1216	c.748G>A	c.(748-750)Gaa>Aaa	p.E250K	GAP43_ENST00000305124.6_Missense_Mutation_p.E214K	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	214					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		AGCTGTAGATGAAACCAAACC	0.433000													112	270					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89381953	89381953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89381953G>A	ENST00000439576.2	+	3	504	c.130G>A	c.(130-132)Ggg>Agg	p.G44R	ACAN_ENST00000558207.1_Missense_Mutation_p.G44R|ACAN_ENST00000352105.7_Missense_Mutation_p.G44R|ACAN_ENST00000559004.1_Missense_Mutation_p.G44R|ACAN_ENST00000561243.1_Missense_Mutation_p.G44R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	44					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGTCCTCCTGGGGACCTCCCT	0.617000													83	81					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17699326	17699326	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:17699326G>A	ENST00000399080.2	-	1	380	c.357C>T	c.(355-357)ccC>ccT	p.P119P		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	119										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GACTTTGTGAGGGGGGAGACT	0.478000													16	66					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114111043	114111043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:114111043G>A	ENST00000297405.5	-	5	1103	c.859C>T	c.(859-861)Caa>Taa	p.Q287*	CSMD3_ENST00000455883.2_Nonsense_Mutation_p.Q287*|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.Q247*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.Q287*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	287	CUB 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCTTCCATTTGAAAATCAGTA	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	56					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165667	172165667	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172165667G>A	ENST00000241256.2	-	1	579	c.537C>T	c.(535-537)ttC>ttT	p.F179F	GHSR_ENST00000427970.1_Silent_p.F179F	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	179					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CGACTAGCACGAAGATGGGCC	0.662000													22	51					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50552915	50552915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50552915C>T	ENST00000262794.5	+	7	1073	c.990C>T	c.(988-990)ccC>ccT	p.P330P	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Silent_p.P330P|MOV10L1_ENST00000545383.1_Silent_p.P330P|MOV10L1_ENST00000540615.1_Silent_p.P310P	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	330					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGATGTGCCCCGTGGTATCTT	0.383000													20	78					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9014622	9014622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9014622C>T	ENST00000397910.4	-	31	38556	c.38353G>A	c.(38353-38355)Gag>Aag	p.E12785K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12787	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATAGCTGCTCCCTGTCCACT	0.572000													32	113					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238287447	238287447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238287447C>T	ENST00000295550.4	-	6	2781	c.2329G>A	c.(2329-2331)Gga>Aga	p.G777R	COL6A3_ENST00000353578.4_Missense_Mutation_p.G571R|COL6A3_ENST00000392004.3_Missense_Mutation_p.G571R|COL6A3_ENST00000392003.2_Missense_Mutation_p.G370R|COL6A3_ENST00000409809.1_Missense_Mutation_p.G571R|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000346358.4_Intron|COL6A3_ENST00000347401.3_Missense_Mutation_p.G576R	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	777	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGGCTAGCTCCCACACAAAAA	0.552000													8	28					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171520744	171520744	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:171520744G>C	ENST00000176763.5	-	9	1569	c.1226C>G	c.(1225-1227)cCc>cGc	p.P409R		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	409							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTTCCGCAGGGGCACAGGCAC	0.627000													10	56					0	0	1	0	0
TRAV1-2	28692	broad.mit.edu	37	14	22111137	22111137	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22111137C>T	ENST00000390423.2	+	0	29																											CTTCTGCAGACTCCAATGGCT	0.507000													6	25					0	0	1	0	0
SNPH	9751	broad.mit.edu	37	20	1276964	1276964	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1276964C>T	ENST00000381867.1	+	4	723	c.81C>T	c.(79-81)tcC>tcT	p.S27S	RAD21L1_ENST00000381882.2_Intron|SNPH_ENST00000381873.3_Intron|RAD21L1_ENST00000402452.1_Intron			O15079	SNPH_HUMAN	syntaphilin	0					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			endometrium(2)|large_intestine(4)|lung(10)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GCCCTCTCTCCTCAGCCCCCG	0.677000													4	25					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116720701	116720701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116720701C>T	ENST00000331677.3	+	3	732	c.288C>T	c.(286-288)gcC>gcT	p.A96A	DSE_ENST00000537543.1_Silent_p.A115A|DSE_ENST00000452085.3_Silent_p.A96A|DSE_ENST00000359564.2_Silent_p.A96A|DSE_ENST00000540275.1_3'UTR			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	96					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		ACTACAGTGCCCGCTGGAATG	0.547000													20	19					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53515095	53515095	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53515095G>A	ENST00000301466.3	+	12	1206	c.1146G>A	c.(1144-1146)tgG>tgA	p.W382*		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	382					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						AGGACTGGTGGAACTCAACGT	0.592000													23	46					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41476198	41476198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41476198G>A	ENST00000314992.5	-	10	1666	c.1476C>T	c.(1474-1476)tcC>tcT	p.S492S	EXD1_ENST00000458580.2_Silent_p.S550S	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	492					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						GAGGGAGTGTGGAAACCACAG	0.443000													35	93					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171258191	171258191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171258191G>A	ENST00000334231.6	+	18	2146	c.2146G>A	c.(2146-2148)Gaa>Aaa	p.E716K	MYO3B_ENST00000408978.4_Missense_Mutation_p.E707K|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000409044.3_Missense_Mutation_p.E707K			Q8WXR4	MYO3B_HUMAN	myosin IIIB	707	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity	p.E707K(1)		breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GCAGCCAGACGAAAACATATG	0.527000													13	34					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17418749	17418749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17418749C>T	ENST00000302539.4	-	32	4107	c.3982G>A	c.(3982-3984)Ggg>Agg	p.G1328R	ABCC8_ENST00000389817.3_Missense_Mutation_p.G1327R	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1327					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCCAGGAGCCCCTCGTAGCTC	0.637000													29	156					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374936	27374936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27374936C>T	ENST00000395762.2	+	11	2522	c.2263C>T	c.(2263-2265)Cct>Tct	p.P755S	IL4R_ENST00000380922.3_Missense_Mutation_p.P740S|IL4R_ENST00000543915.2_Missense_Mutation_p.P755S|IL4R_ENST00000170630.2_Missense_Mutation_p.P755S	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	755					immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GTCCTCGCCCCCTACAACCCC	0.657000													4	48					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074222	9074222	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9074222G>A	ENST00000397910.4	-	3	13427	c.13224C>T	c.(13222-13224)acC>acT	p.T4408T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4410	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTAAGGCATGGTTGATGTGT	0.473000													38	136					0	0	1	0	0
IGHG4	3503	broad.mit.edu	37	14	106091547	106091547	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106091547C>T	ENST00000390543.2	-	0	346																											TGATGGTCCCCCCAGGAACTC	0.627000													26	54					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58980192	58980192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58980192C>T	ENST00000361050.3	-	1	232	c.147G>A	c.(145-147)ggG>ggA	p.G49G		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	49	MACPF.					integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				TGTCCCAGCCCCCTCCAGGTA	0.498000													71	158					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15053097	15053097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15053097C>T	ENST00000248072.3	+	1	797	c.797C>T	c.(796-798)cCt>cTt	p.P266L		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					GTTACACCACCTTCTAGGACA	0.537000													49	112					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120732746	120732746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120732746C>T	ENST00000527524.2	+	9	1110	c.823C>T	c.(823-825)Cat>Tat	p.H275Y	GRIK4_ENST00000438375.2_Missense_Mutation_p.H275Y			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	275					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CAACCAATCCCATGCTTTCTT	0.522000													89	211					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37299050	37299050	+	Missense_Mutation	SNP	G	G	A	rs146473381		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:37299050G>A	ENST00000231498.3	-	32	3916	c.3713C>T	c.(3712-3714)tCg>tTg	p.S1238L	NUP155_ENST00000381843.2_Missense_Mutation_p.S1179L|NUP155_ENST00000502533.1_5'UTR|NUP155_ENST00000513532.1_Missense_Mutation_p.S1174L	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	1238					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATTCTATCCGAGGAGCTCAA	0.373000													5	50					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7691433	7691433	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7691433C>T	ENST00000572933.1	+	44	8231	c.6771C>T	c.(6769-6771)ttC>ttT	p.F2257F	DNAH2_ENST00000389173.2_Silent_p.F2257F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2257	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AACGCATGTTCGAAAAGCTCA	0.542000													10	27					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119216622	119216622	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119216622G>A	ENST00000555262.1	-	4	447	c.288C>T	c.(286-288)ccC>ccT	p.P96P	MFRP_ENST00000530681.1_Silent_p.P96P|MFRP_ENST00000360167.4_Silent_p.P96P|MFRP_ENST00000449574.2_Silent_p.P96P|C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CCCCAGATGGGGGTGCAGCCT	0.642000													22	48					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94512578	94512578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94512578C>T	ENST00000370225.3	-	19	2901	c.2815G>A	c.(2815-2817)Gag>Aag	p.E939K	ABCA4_ENST00000535735.1_Missense_Mutation_p.E865K	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	939	ABC transporter 1.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CCACAGGGCTCAAAAATCTTT	0.507000													24	249					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67941580	67941580	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:67941580C>T	ENST00000252336.6	+	9	2583	c.2211C>T	c.(2209-2211)ccC>ccT	p.P737P	STARD8_ENST00000374597.3_Silent_p.P737P|STARD8_ENST00000374599.3_Silent_p.P817P	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	737	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						AGGATAGCCCCTCTCCCAGGT	0.577000													17	16					0	0	1	0	0
ACMSD	130013	broad.mit.edu	37	2	135625210	135625210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:135625210G>A	ENST00000356140.5	+	6	684	c.548G>A	c.(547-549)cGa>cAa	p.R183Q	ACMSD_ENST00000283054.4_Missense_Mutation_p.R125Q|AC016725.4_ENST00000413962.1_RNA|AC016725.4_ENST00000428857.1_RNA|AC016725.4_ENST00000392929.2_RNA|AC016725.4_ENST00000537615.1_RNA|ACMSD_ENST00000392928.1_Missense_Mutation_p.R125Q	NM_138326.2	NP_612199.2	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	183					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			endometrium(3)|large_intestine(4)|lung(6)|skin(1)	14				BRCA - Breast invasive adenocarcinoma(221;0.115)		ATGGATGGACGAATGGCCAAA	0.498000													54	94					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48429431	48429431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48429431G>A	ENST00000224605.2	-	2	720	c.455C>T	c.(454-456)cCg>cTg	p.P152L		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	152					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CTTGGCCCGCGGCTTGCATAG	0.652000													3	17					0	0	1	0	0
PRAM1	84106	broad.mit.edu	37	19	8563993	8563993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8563993G>A	ENST00000423345.4	-	2	1219	c.699C>T	c.(697-699)gtC>gtT	p.V233V	PRAM1_ENST00000255612.3_Silent_p.V233V			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	281	Pro-rich.						lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						GGAGGCCACCGACCTGAGGCT	0.632000													13	32					0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886538	57886538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57886538G>A	ENST00000302610.1	-	1	378	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				AGTGGGTTGCGAATGGCAGCA	0.562000													12	56					0	0	1	0	0
CLEC6A	93978	broad.mit.edu	37	12	8610536	8610536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8610536G>A	ENST00000382073.3	+	2	260	c.74G>A	c.(73-75)gGg>gAg	p.G25E		NM_001007033.1	NP_001007034.1	Q6EIG7	CLC6A_HUMAN	C-type lectin domain family 6, member A	25					defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)|large_intestine(2)|lung(7)	10	Lung SC(5;0.184)					TCTGTGGCTGGGATTTCCATT	0.493000													24	51					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729423	18729423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18729423C>T	ENST00000440756.2	-	3	1053	c.951G>A	c.(949-951)caG>caA	p.Q317Q	PSD3_ENST00000327040.8_Silent_p.Q317Q|PSD3_ENST00000523619.1_Silent_p.Q252Q			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	317					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTATAGGATGCTGGGTCTCTC	0.502000													52	136					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188066	152188066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152188066G>A	ENST00000368801.2	-	3	6114	c.6039C>T	c.(6037-6039)tcC>tcT	p.S2013S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2013					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGGTAGAGGAATGACCTG	0.557000													104	1413					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82124521	82124521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82124521G>A	ENST00000199936.4	+	4	872	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	227					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	GGCCCCAATGGAAAGGCTGGC	0.413000													5	39					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57013070	57013070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:57013070C>T	ENST00000370706.4	+	10	2431	c.2187C>T	c.(2185-2187)atC>atT	p.I729I	RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Silent_p.I729I|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|ZNF451_ENST00000491832.2_Silent_p.I729I|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	729					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AGAGTTACATCTGTAAAGTCA	0.383000													10	42					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37774261	37774261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37774261G>A	ENST00000264741.5	+	19	2382	c.2126G>A	c.(2125-2127)gGa>gAa	p.G709E		NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	709					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TGCAGCGTGGGATTTCCTTTC	0.562000													3	17					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764593	92764593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92764593G>A	ENST00000318238.4	-	5	1908	c.692C>T	c.(691-693)tCa>tTa	p.S231L	SAMD9L_ENST00000411955.1_Missense_Mutation_p.S231L|SAMD9L_ENST00000437805.1_Missense_Mutation_p.S231L	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	231										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			ATTGGTGCGTGAATTCATACA	0.438000													42	96					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61459284	61459284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61459284G>A	ENST00000343916.3	+	17	859	c.856G>A	c.(856-858)Ggt>Agt	p.G286S		NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	286	Triple-helical region 3 (COL3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					GGGCAGACCTGGTCCCAAGGG	0.642000													33	49					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363912	22363912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22363912C>T	ENST00000397121.2	-	3	924	c.607G>A	c.(607-609)Ggc>Agc	p.G203S		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAGGCTTTGCCACATTCTTCA	0.358000													26	84					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22079094	22079094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22079094G>A	ENST00000454243.2	-	5	1339	c.765C>T	c.(763-765)ccC>ccT	p.P255P	PHYHIP_ENST00000321613.3_Silent_p.P255P	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	255										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		TGTCCAGGAGGGGCAGGCGGT	0.622000													14	40					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8971824	8971824	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8971824C>T	ENST00000397910.4	-	78	42971	c.42767_splice	c.e78-1	p.T14256_splice	MUC16_ENST00000380951.5_Splice_Site_p.T897_splice	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14319	SEA 15.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CGGAGTCCATCCTAGGGACAG	0.507000													5	9					0	0	1	0	0
ORM1	5004	broad.mit.edu	37	9	117087420	117087420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117087420C>T	ENST00000259396.8	+	5	606	c.528C>T	c.(526-528)acC>acT	p.T176T	ORM1_ENST00000477456.1_3'UTR	NM_000607.2	NP_000598.2	P02763	A1AG1_HUMAN	orosomucoid 1	176					acute-phase response|regulation of immune system process|transport	extracellular space	protein binding			endometrium(2)|large_intestine(4)|lung(2)	8		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	TCGTGTACACCGATTGGAAAA	0.577000													21	52					0	0	1	0	0
ACTG2	72	broad.mit.edu	37	2	74140694	74140694	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74140694C>T	ENST00000409624.1	+	7	1177	c.534C>T	c.(532-534)cgC>cgT	p.R178R	ACTG2_ENST00000345517.3_Silent_p.R178R|ACTG2_ENST00000409731.3_Silent_p.R135R			P63267	ACTH_HUMAN	actin, gamma 2, smooth muscle, enteric	178					muscle contraction	cytoskeleton|cytosol	ATP binding			large_intestine(3)|lung(14)|skin(1)	18						CCATCATGCGCCTGGACTTGG	0.552000													32	105					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58111395	58111395	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58111395C>T	ENST00000357272.4	+	23	4151	c.3986C>T	c.(3985-3987)tCt>tTt	p.S1329F	FLNB_ENST00000493452.1_Missense_Mutation_p.S1160F|FLNB_ENST00000490882.1_Missense_Mutation_p.S1329F|FLNB_ENST00000429972.2_Missense_Mutation_p.S1329F|FLNB_ENST00000419752.2_Missense_Mutation_p.S1160F|FLNB_ENST00000348383.5_Missense_Mutation_p.S1329F|FLNB_ENST00000295956.4_Missense_Mutation_p.S1329F|FLNB_ENST00000358537.3_Missense_Mutation_p.S1329F			O75369	FLNB_HUMAN	filamin B, beta	1329	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding	p.S1329Y(2)		NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TGCCAGCCATCTAGGGTGCAA	0.517000													29	90					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55179107	55179107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55179107C>T	ENST00000391736.1	+	13	1378	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S	LILRB4_ENST00000270452.2_Missense_Mutation_p.P355S|LILRB4_ENST00000391734.3_Intron|LILRB4_ENST00000391733.3_Missense_Mutation_p.P356S|LILRB4_ENST00000430952.2_Missense_Mutation_p.P354S	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	355						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CGATGAAGACCCCCAGGCAGT	0.567000													16	80					0	0	1	0	0
POMC	5443	broad.mit.edu	37	2	25384191	25384191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:25384191C>T	ENST00000405623.1	-	3	1018	c.563G>A	c.(562-564)gGa>gAa	p.G188E	POMC_ENST00000264708.3_Missense_Mutation_p.G188E|POMC_ENST00000395826.2_Missense_Mutation_p.G188E|POMC_ENST00000380794.1_Missense_Mutation_p.G188E			P01189	COLI_HUMAN	proopiomelanocortin	188					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	GGGGCCATCTCCCTCCCGGAG	0.706000													6	8					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475029	16475029	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16475029G>A	ENST00000358432.5	-	3	821	c.667C>T	c.(667-669)Ctg>Ttg	p.L223L	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	223	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ACAGTGGCCAGGGAAGGTGCA	0.667000													7	55					0	0	1	0	0
IL9R	3581	broad.mit.edu	37	X	155235133	155235133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:155235133C>T	ENST00000424344.3	+	7	1074	c.707C>T	c.(706-708)cCc>cTc	p.P236L	IL9R_ENST00000244174.5_Missense_Mutation_p.P257L|IL9R_ENST00000540897.1_Missense_Mutation_p.P282L|IL9R_ENST00000369423.2_Missense_Mutation_p.P292L			Q01113	IL9R_HUMAN	interleukin 9 receptor	257	Fibronectin type-III.				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTCCAGGCTCCCCAGAGACAA	0.617000													9	31					0	0	1	0	0
ZNF121	7675	broad.mit.edu	37	19	9677162	9677162	+	Silent	SNP	G	G	A	rs147272207		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9677162G>A	ENST00000586602.1	-	6	1043	c.627C>T	c.(625-627)ttC>ttT	p.F209F	ZNF121_ENST00000320451.6_Silent_p.F209F			P58317	ZN121_HUMAN	zinc finger protein 121	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(4)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	24						AGCGCCCAGCGAAGGCTCTTC	0.418000													29	60					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123152144	123152144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123152144G>A	ENST00000466202.1	-	2	827	c.251C>T	c.(250-252)tCa>tTa	p.S84L	IQUB_ENST00000434450.1_Missense_Mutation_p.S84L|IQUB_ENST00000324698.6_Missense_Mutation_p.S84L|IQUB_ENST00000488987.1_Intron			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	84										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						TTGTCTTGGTGATATAACCTC	0.398000													17	194					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27147884	27147884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27147884C>T	ENST00000288699.6	+	3	549	c.391C>T	c.(391-393)Cac>Tac	p.H131Y	DPYSL5_ENST00000401478.1_Missense_Mutation_p.H131Y	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	131					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTACGCCCTCCACGTGGGGAT	0.612000													12	32					0	0	1	0	0
GHRH	2691	broad.mit.edu	37	20	35885233	35885233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35885233G>A	ENST00000373614.2	-	2	171	c.60C>T	c.(58-60)tcC>tcT	p.S20S	GHRH_ENST00000373611.2_Silent_p.S20S|GHRH_ENST00000237527.3_Silent_p.S20S			P01286	SLIB_HUMAN	growth hormone releasing hormone	20					activation of adenylate cyclase activity by G-protein signaling pathway|adenohypophysis development|growth hormone secretion|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of circadian sleep/wake cycle, REM sleep|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to food	extracellular space|terminal button	growth hormone-releasing hormone activity|growth hormone-releasing hormone receptor binding			lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Myeloproliferative disorder(115;0.00878)				GGGGAGGTGGGGAGCAGTGGG	0.597000													8	13					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13769648	13769648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13769648C>T	ENST00000265104.4	-	57	9786	c.9682G>A	c.(9682-9684)Gaa>Aaa	p.E3228K	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3228	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGCTCCTTTTCTTTCGCTTCC	0.433000									Kartagener syndrome				65	149					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96332162	96332162	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:96332162C>T	ENST00000231368.5	+	7	2168	c.1476C>T	c.(1474-1476)ttC>ttT	p.F492F	LNPEP_ENST00000395770.3_Silent_p.F478F	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	492					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		TTGCCACTTTCATGGAGTATT	0.393000													11	53					0	0	1	0	0
IGLC7	28834	broad.mit.edu	37	22	23265006	23265006	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23265006C>T	ENST00000390331.1	+	0	241																											CAGTGGAAGTCCCACAGAAGC	0.612000													12	66					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6026741	6026741	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:6026741T>C	ENST00000265849.7	-	11	1760	c.1655A>G	c.(1654-1656)cAt>cGt	p.H552R	PMS2_ENST00000382321.4_Intron|PMS2_ENST00000469652.1_Intron|PMS2_ENST00000406569.3_Missense_Mutation_p.H552R|PMS2_ENST00000441476.2_Missense_Mutation_p.H446R	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	552					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CTGGTTTGAATGGCAGTCCAC	0.473000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				88	217					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49087963	49087963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49087963G>A	ENST00000261900.3	-	9	1256	c.1034C>T	c.(1033-1035)cCt>cTt	p.P345L		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	345					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						ACCCTGAGTAGGTTCTAGTTT	0.473000													32	76					0	0	1	0	0
ZNF688	146542	broad.mit.edu	37	16	30581396	30581396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30581396G>A	ENST00000223459.6	-	3	1776	c.672C>T	c.(670-672)ttC>ttT	p.F224F	ZNF688_ENST00000395219.1_Silent_p.F210F	NM_145271.3	NP_660314.1	P0C7X2	ZN688_HUMAN	zinc finger protein 688	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8						CTTCCACTGCGAACTTCCTCT	0.706000													5	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569663	179569663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179569663C>T	ENST00000589042.1	-	104	29859	c.29635G>A	c.(29635-29637)Gac>Aac	p.D9879N	TTN_ENST00000342992.6_Missense_Mutation_p.D8635N|TTN_ENST00000591111.1_Missense_Mutation_p.D9562N|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9562	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTTTCGTCCCTCTCTGAC	0.323000													44	139					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42607138	42607138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42607138G>A	ENST00000359486.3	-	1	4310	c.4174C>T	c.(4174-4176)Cct>Tct	p.P1392S	TCF20_ENST00000335626.4_Missense_Mutation_p.P1392S	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CCTTCAGGAGGACCACTCTTC	0.507000													19	110					0	0	1	0	0
RETSAT	54884	broad.mit.edu	37	2	85577343	85577343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:85577343G>A	ENST00000295802.4	-	4	731	c.619C>T	c.(619-621)Cat>Tat	p.H207Y	RETSAT_ENST00000457495.2_Missense_Mutation_p.H146Y|RETSAT_ENST00000263854.6_Missense_Mutation_p.H207Y	NM_017750.3	NP_060220.3	Q6NUM9	RETST_HUMAN	retinol saturase (all-trans-retinol 13,14-reductase)	207					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	30					Vitamin A(DB00162)	AGGATGGCATGAGGGGCTCCA	0.562000													14	59					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146829430	146829430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:146829430G>A	ENST00000361727.3	+	8	1693	c.1177G>A	c.(1177-1179)Gac>Aac	p.D393N		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	393					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCTTAACCAGGACCTGTTCTC	0.478000										HNSCC(39;0.1)			30	83					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40964869	40964869	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:40964869G>A	ENST00000313164.9	+	14	2135	c.1776G>A	c.(1774-1776)ggG>ggA	p.G592G		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	592	Sushi 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				TTCCTGTGGGGAAAAATGTAG	0.368000													27	65					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64738836	64738836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64738836G>A	ENST00000413366.3	+	13	1508	c.1482G>A	c.(1480-1482)acG>acA	p.T494T		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	494	Protein kinase.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	ATGGAGTCACGACCAGGACCT	0.483000													36	79					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66192507	66192507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66192507G>A	ENST00000311034.2	+	7	2322	c.2146G>A	c.(2146-2148)Gat>Aat	p.D716N		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	716					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CATCTTCATGGATCTCTCTAC	0.592000													45	71					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47938716	47938716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47938716C>T	ENST00000402813.3	-	10	2144	c.2002G>A	c.(2002-2004)Ggg>Agg	p.G668R	CNGA1_ENST00000514170.1_Missense_Mutation_p.G599R|CNGA1_ENST00000544810.1_Missense_Mutation_p.G599R|CNGA1_ENST00000420489.2_Missense_Mutation_p.G599R|CNGA1_ENST00000358519.4_Missense_Mutation_p.G599R			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	599					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						ATCTGCTTCCCTTTCTCTTCC	0.418000													64	197					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62871152	62871152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62871152G>A	ENST00000536311.1	+	22	3578	c.3214G>A	c.(3214-3216)Gag>Aag	p.E1072K	MYT1_ENST00000328439.1_Missense_Mutation_p.E1045K			Q01538	MYT1_HUMAN	myelin transcription factor 1	1045					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CATCGAGGAGGAGAACAAGCT	0.577000													28	76					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2983282	2983282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2983282G>A	ENST00000342628.2	-	2	476	c.363C>T	c.(361-363)ctC>ctT	p.L121L	FOXM1_ENST00000361953.3_Silent_p.L121L|FOXM1_ENST00000359843.3_Silent_p.L121L|FOXM1_ENST00000537018.1_5'UTR	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	121					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TTTGAGGCCGGAGTCCTGGAG	0.542000													36	99					0	0	1	0	0
MSTN	2660	broad.mit.edu	37	2	190925110	190925110	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:190925110A>C	ENST00000260950.4	-	2	557	c.425T>G	c.(424-426)tTt>tGt	p.F142C	C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin	142					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TTTAGAGCTAAATTTAAAGAA	0.333000													18	59					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134896158	134896158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134896158C>T	ENST00000607359.1	+	6	1244	c.1244C>T	c.(1243-1245)aCc>aTc	p.T415I				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GCCTACGAGACCCACGGCCTT	0.607000													12	26					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219760	67219760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67219760G>A	ENST00000312457.2	-	1	440	c.436C>T	c.(436-438)Cgc>Tgc	p.R146C		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	146						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AGGGGCAGGCGGACTGGGCGG	0.701000													14	32					0	0	1	0	0
TTC36	143941	broad.mit.edu	37	11	118399470	118399470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118399470C>T	ENST00000539546.1	+	3	429	c.94C>T	c.(94-96)Cgt>Tgt	p.R32C	RP11-770J1.3_ENST00000556583.1_RNA|RP11-770J1.3_ENST00000532597.1_RNA|RP11-770J1.3_ENST00000525992.2_RNA|RP11-770J1.3_ENST00000528578.1_RNA|TTC36_ENST00000302783.4_Missense_Mutation_p.R91C|RP11-770J1.3_ENST00000554407.1_RNA			A6NLP5	TTC36_HUMAN	tetratricopeptide repeat domain 36	91							binding			lung(2)	2						CTACAACAACCGTGCCCAGGC	0.637000													22	31					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104064570	104064570	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104064570C>T	ENST00000388887.2	+	22	2560	c.2356C>T	c.(2356-2358)Cct>Tct	p.P786S		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	786					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TAAATACGGACCTCGGTGTAA	0.557000													4	22					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513335	99513335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:99513335G>A	ENST00000261037.3	+	5	970	c.590G>A	c.(589-591)gGa>gAa	p.G197E	COL8A1_ENST00000273342.4_Missense_Mutation_p.G197E	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	197	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGACCACAAGGACCTCCAGGG	0.587000													18	46					0	0	1	0	0
MICU1	10367	broad.mit.edu	37	10	74167714	74167714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74167714G>A	ENST00000398761.4	-	12	1291	c.1159C>T	c.(1159-1161)Cat>Tat	p.H387Y	MICU1_ENST00000398763.4_Missense_Mutation_p.H187Y|MICU1_ENST00000401998.3_Missense_Mutation_p.H385Y|MICU1_ENST00000418483.2_Missense_Mutation_p.H187Y|MICU1_ENST00000361114.5_Missense_Mutation_p.H385Y			Q9BPX6	MICU1_HUMAN	mitochondrial calcium uptake 1	385					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding										CCAGCCATATGGTAAAAACTC	0.403000													12	41					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56490832	56490832	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56490832G>A	ENST00000291971.3	+	9	3020	c.2949G>A	c.(2947-2949)ctG>ctA	p.L983L	NLRP8_ENST00000590542.1_Silent_p.L964L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	983						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		ACCAACATCTGAGACATCTGG	0.493000													50	112					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38936375	38936375	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38936375C>T	ENST00000302328.3	-	15	2682	c.2484G>A	c.(2482-2484)agG>agA	p.R828R	SCN11A_ENST00000456224.3_Silent_p.R828R|SCN11A_ENST00000444237.2_Silent_p.R828R|SCN11A_ENST00000450244.1_Silent_p.R828R	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	828					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTTAGTTTTCCTGGCCTCTC	0.468000													20	58					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20856143	20856143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20856143G>A	ENST00000262715.5	-	18	2645	c.2605C>T	c.(2605-2607)Cca>Tca	p.P869S	TEP1_ENST00000556935.1_Missense_Mutation_p.P761S	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	869					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GTCTTTCCTGGGGGTGGTGGA	0.512000													21	61					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771847	143771847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143771847G>A	ENST00000408898.2	+	1	573	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					CTTTTTCTGTGAAATTATGGC	0.463000													65	161					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71891404	71891404	+	Silent	SNP	C	C	T	rs151276652	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71891404C>T	ENST00000258104.3	+	45	5170	c.4893C>T	c.(4891-4893)ttC>ttT	p.F1631F	DYSF_ENST00000410041.1_Silent_p.F1649F|DYSF_ENST00000429174.2_Silent_p.F1652F|DYSF_ENST00000409744.1_Silent_p.F1639F|DYSF_ENST00000410020.3_Silent_p.F1670F|DYSF_ENST00000394120.2_Silent_p.F1632F|DYSF_ENST00000409366.1_Silent_p.F1653F|DYSF_ENST00000409582.3_Silent_p.F1669F|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Silent_p.F1662F|DYSF_ENST00000409651.1_Silent_p.F1663F|DYSF_ENST00000409762.1_Silent_p.F1648F	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1631	C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GCAGGATGTTCGAGCTGACCT	0.572000													33	65					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107791	55107791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55107791C>T	ENST00000251372.3	+	7	1278	c.1096C>T	c.(1096-1098)Ccc>Tcc	p.P366S	LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000453777.1_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	366	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		AGCTGATGCCCCCCTCCGTCT	0.592000													51	110					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121290798	121290798	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121290798C>T	ENST00000297848.3	+	28	3732	c.3462C>T	c.(3460-3462)tcC>tcT	p.S1154S	COL14A1_ENST00000309791.4_Silent_p.S1154S|COL14A1_ENST00000247781.3_Silent_p.S1059S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1154	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACAAAATCTCCAGGGAGATGC	0.348000													6	56					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57828693	57828693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57828693C>T	ENST00000309668.2	+	1	151	c.24C>T	c.(22-24)gcC>gcT	p.A8A	INHBC_ENST00000550133.1_Silent_p.A8A	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	8					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						TGCTTCTGGCCTTTCTCCTCC	0.602000													7	39					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39804951	39804951	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39804951C>T	ENST00000248668.4	-	1	1025	c.1026G>A	c.(1024-1026)ggG>ggA	p.G342G		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	342	Ig-like.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGCTGGAGTTCCCCAGCAGCC	0.687000													7	8					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51743021	51743021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51743021C>T	ENST00000395052.3	+	2	256	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L	GRM2_ENST00000442933.2_Silent_p.L8L|GRM2_ENST00000475478.1_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	8					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCTTGCGCTCCTGGCACTGCT	0.632000													7	19					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155451141	155451141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155451141G>A	ENST00000461783.3	+	6	2057	c.784G>A	c.(784-786)Gag>Aag	p.E262K	TIAM2_ENST00000318981.5_Missense_Mutation_p.E262K|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000529824.2_Missense_Mutation_p.E262K|TIAM2_ENST00000360366.4_Missense_Mutation_p.E262K|TIAM2_ENST00000456144.1_Missense_Mutation_p.E262K			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	262					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGAGCTGAGCGAGGCTGAGGG	0.617000													34	41					0	0	1	0	0
TNFSF14	8740	broad.mit.edu	37	19	6665012	6665012	+	Silent	SNP	G	G	A	rs143839697		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6665012G>A	ENST00000326176.9	-	5	921	c.540C>T	c.(538-540)gtC>gtT	p.V180V	TNFSF14_ENST00000599359.1_Silent_p.V216V|TNFSF14_ENST00000245912.3_Silent_p.V180V	NM_003807.3|NM_172014.2	NP_003798.2|NP_742011.2	O43557	TNF14_HUMAN	tumor necrosis factor (ligand) superfamily, member 14	216					cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding	p.V216V(1)		breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18						GCACACGGACGACCACCTTCT	0.622000													39	83					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90129102	90129102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90129102C>T	ENST00000268138.7	+	4	1445	c.1340C>T	c.(1339-1341)tCc>tTc	p.S447F	RP11-429B14.1_ENST00000559041.1_RNA|TICRR_ENST00000560985.1_Missense_Mutation_p.S446F					TOPBP1-interacting checkpoint and replication regulator																		GACACAGCTTCCCTTTTCTCA	0.483000													84	72					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86416290	86416290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86416290G>A	ENST00000361669.2	+	3	2281	c.1182G>A	c.(1180-1182)gtG>gtA	p.V394V	GRM3_ENST00000394720.2_Silent_p.V392V|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Silent_p.V394V|GRM3_ENST00000536043.1_Silent_p.V266V	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	394					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGTTTGTGGTGAACGCGGTGT	0.547000													32	91					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117655926	117655926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117655926C>T	ENST00000317775.6	-	28	4899	c.4214G>A	c.(4213-4215)cGa>cAa	p.R1405Q	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.R1439Q	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1405					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTCGTACGTTCGCAGGGTGAC	0.478000													78	292					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47280923	47280923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47280923G>A	ENST00000271153.4	+	8	1093	c.1057G>A	c.(1057-1059)Gac>Aac	p.D353N	CYP4B1_ENST00000371923.4_Missense_Mutation_p.D354N|CYP4B1_ENST00000371919.4_Missense_Mutation_p.D339N|CYP4B1_ENST00000452782.2_Missense_Mutation_p.D191N			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	353					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					AGGGGACCAGGACTTCTTCCA	0.582000													13	27					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1262685	1262685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1262685G>A	ENST00000447027.1	+	31	4642	c.4584G>A	c.(4582-4584)ggG>ggA	p.G1528G	MUC5B_ENST00000529681.1_Silent_p.G1525G			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1525	7 X Cys-rich subdomain repeats.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AACTTGGAGGGGACGTTGAGT	0.607000													11	16					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74013982	74013982	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74013982G>A	ENST00000301607.3	-	14	1801	c.1548C>T	c.(1546-1548)ggC>ggT	p.G516G	EVPL_ENST00000586740.1_Silent_p.G538G	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	516	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CCAGGTCTGAGCCAGATGGAG	0.657000													18	55					0	0	1	0	0
STARD7	56910	broad.mit.edu	37	2	96859059	96859059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96859059G>A	ENST00000337288.5	-	4	964	c.581C>T	c.(580-582)gCc>gTc	p.A194V	STARD7_ENST00000462501.1_5'UTR	NM_020151.3	NP_064536.2	Q9NQZ5	STAR7_HUMAN	StAR-related lipid transfer (START) domain containing 7	194	START.					mitochondrion				endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|stomach(2)	14						GATTACCAGGGCATCCCATTT	0.423000													48	98					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45923763	45923763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45923763C>T	ENST00000348697.2	+	4	505	c.358C>T	c.(358-360)Cag>Tag	p.Q120*	FBLN1_ENST00000402984.3_Nonsense_Mutation_p.Q158*|FBLN1_ENST00000327858.6_Nonsense_Mutation_p.Q120*|FBLN1_ENST00000340923.5_Nonsense_Mutation_p.Q120*|FBLN1_ENST00000442170.2_Nonsense_Mutation_p.Q120*|FBLN1_ENST00000262722.7_Nonsense_Mutation_p.Q120*			P23142	FBLN1_HUMAN	fibulin 1	120	Anaphylatoxin-like 3.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GAGGGCGGCCCAGGCCCAGGG	0.627000													20	116					0	0	1	0	0
RGP1	9827	broad.mit.edu	37	9	35750689	35750689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35750689G>A	ENST00000378078.4	+	4	429	c.288G>A	c.(286-288)ccG>ccA	p.P96P	RGP1_ENST00000456972.2_Silent_p.P136P	NM_001080496.2	NP_001073965.2	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog (S. cerevisiae)	96										cervix(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTACTCCACCGAAAATTCTAT	0.458000													12	48					0	0	1	0	0
TRIM32	22954	broad.mit.edu	37	9	119461243	119461243	+	Missense_Mutation	SNP	C	C	A	rs3747835	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119461243C>A	ENST00000450136.1	+	2	1383	c.1222C>A	c.(1222-1224)Cgc>Agc	p.R408S	ASTN2_ENST00000373996.3_Intron|ASTN2_ENST00000361477.3_Intron|ASTN2_ENST00000361209.2_Intron|ASTN2_ENST00000313400.4_Intron|TRIM32_ENST00000373983.2_Missense_Mutation_p.R408S	NM_001099679.1|NM_012210.3	NP_001093149.1|NP_036342.2	Q13049	TRI32_HUMAN	tripartite motif containing 32	408			R -> C (in dbSNP:rs3747835).		fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	26						GAAGGAAATCCGCCGCAGCCC	0.512000													51	119					4.78724e-31	4.81961e-31	1	1	0
IFT80	57560	broad.mit.edu	37	3	160025566	160025566	+	Missense_Mutation	SNP	G	G	A	rs140972476		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:160025566G>A	ENST00000326448.7	-	10	1393	c.961C>T	c.(961-963)Cgt>Tgt	p.R321C	IFT80_ENST00000496589.1_Missense_Mutation_p.R184C|RP11-432B6.3_ENST00000483754.1_Missense_Mutation_p.R492C|IFT80_ENST00000483465.1_Missense_Mutation_p.R184C	NM_020800.2	NP_065851.1	Q9P2H3	IFT80_HUMAN	intraflagellar transport 80 homolog (Chlamydomonas)	321						cilium axoneme|microtubule basal body				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(12)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AGAACATTACGAACCTAAACA	0.289000													8	30					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15686188	15686188	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15686188C>T	ENST00000378076.3	-	13	1593	c.1240G>A	c.(1240-1242)Gat>Aat	p.D414N		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	414					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CCTCTTTGATCCTTGCCTGCA	0.398000													21	32					0	0	1	0	0
IFNA14	3448	broad.mit.edu	37	9	21239489	21239489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21239489C>T	ENST00000380222.2	-	1	489	c.446G>A	c.(445-447)aGa>aAa	p.R149K		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	149					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AAGAGTGATTCTTTGGAAGTA	0.458000													136	307					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100197701	100197701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100197701C>T	ENST00000241071.6	+	9	1576	c.1254C>T	c.(1252-1254)caC>caT	p.H418H	FBXO24_ENST00000468962.1_Silent_p.H406H|PCOLCE-AS1_ENST00000544873.1_RNA|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000360609.2_3'UTR|FBXO24_ENST00000427939.2_Silent_p.H456H	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	418						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GCCTCAACCACTCCCTGGTGC	0.692000													3	13					0	0	1	0	0
AKR1C1	1645	broad.mit.edu	37	10	5014844	5014844	+	Missense_Mutation	SNP	G	G	A	rs140396306		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5014844G>A	ENST00000380872.4	+	7	941	c.749G>A	c.(748-750)cGa>cAa	p.R250Q	AKR1C1_ENST00000434459.2_Missense_Mutation_p.R250Q|AKR1C1_ENST00000477661.1_3'UTR	NM_001353.5	NP_001344.2			aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						AAGCACAAGCGAACCCCAGCC	0.597000													31	127					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41519017	41519017	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41519017C>T	ENST00000396942.1	-	42	5768	c.5685G>A	c.(5683-5685)gtG>gtA	p.V1895V	ANK1_ENST00000522543.1_Intron|ANK1_ENST00000289734.7_Silent_p.V1870V|ANK1_ENST00000347528.4_Intron|ANK1_ENST00000379758.2_Intron|ANK1_ENST00000352337.4_Silent_p.V1848V|ANK1_ENST00000265709.8_Intron|ANK1_ENST00000522231.1_Intron|ANK1_ENST00000396945.1_Intron|ANK1_ENST00000457297.1_Intron|RP11-930P14.1_ENST00000522388.1_RNA|ANK1_ENST00000314214.8_Silent_p.V145V|RP11-930P14.1_ENST00000585088.1_RNA|RP11-930P14.1_ENST00000520418.1_RNA			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	0					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGGCCCGCTTCACTATCTGCG	0.612000													20	60					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145562977	145562977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145562977G>A	ENST00000355594.4	+	10	2752	c.2665G>A	c.(2665-2667)Gcc>Acc	p.A889T		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	889										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGCTCAGGCAGCCGAACAAGA	0.647000													15	38					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2717932	2717932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:2717932G>A	ENST00000382082.3	+	1	431	c.193G>A	c.(193-195)Gac>Aac	p.D65N		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	65						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		CGAGGAGGAGGACCAGTGGAA	0.662000													5	52					0	0	1	0	0
MTA1	9112	broad.mit.edu	37	14	105936526	105936526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105936526G>A	ENST00000331320.7	+	21	2336	c.2122G>A	c.(2122-2124)Gac>Aac	p.D708N	RP11-521B24.5_ENST00000552675.1_RNA|MTA1_ENST00000406191.1_Missense_Mutation_p.D696N|MTA1_ENST00000405646.1_Missense_Mutation_p.D691N|MTA1_ENST00000435036.2_Missense_Mutation_p.D248N	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1	708					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GCCCGTCAACGACGAGCCCAT	0.776000													12	17					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130479928	130479928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130479928G>A	ENST00000373289.3	+	4	383	c.303G>A	c.(301-303)cgG>cgA	p.R101R	PTRH1_ENST00000419060.1_Intron|TTC16_ENST00000393748.4_5'UTR|PTRH1_ENST00000429848.1_Intron	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	101							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						ATGCCTTACGGGCTGAGGCCT	0.627000													24	41					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130712923	130712923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130712923G>A	ENST00000510168.1	+	22	2588	c.2038G>A	c.(2038-2040)Gat>Aat	p.D680N	ATP2C1_ENST00000508532.1_Missense_Mutation_p.D680N|ATP2C1_ENST00000504381.1_Missense_Mutation_p.D625N|ATP2C1_ENST00000359644.3_Missense_Mutation_p.D680N|ATP2C1_ENST00000393221.4_Missense_Mutation_p.D714N|ATP2C1_ENST00000428331.2_Missense_Mutation_p.D680N|ATP2C1_ENST00000422190.2_Missense_Mutation_p.D680N|ATP2C1_ENST00000504948.1_Missense_Mutation_p.D664N|ATP2C1_ENST00000505330.1_Missense_Mutation_p.D664N|ATP2C1_ENST00000507488.2_Missense_Mutation_p.D664N|ATP2C1_ENST00000328560.8_Missense_Mutation_p.D680N|ATP2C1_ENST00000533801.2_Missense_Mutation_p.D675N|ATP2C1_ENST00000513801.1_Missense_Mutation_p.D664N			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	680					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	CCTAGTGGATGATGATTTTCA	0.458000									Hailey-Hailey disease				43	70					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160679494	160679494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160679494C>T	ENST00000366952.1	-	3	1714	c.233G>A	c.(232-234)aGc>aAc	p.S78N	SLC22A2_ENST00000491092.1_5'UTR|SLC22A2_ENST00000366953.3_Missense_Mutation_p.S99N			O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	99					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GTCGAAGGTGCTCTGGTTCCA	0.677000													32	39					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6952194	6952194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6952194G>A	ENST00000229264.3	+	5	562	c.157G>A	c.(157-159)Gga>Aga	p.G53R	GNB3_ENST00000435982.2_Missense_Mutation_p.G53R	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	53					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						GACGTTAAGGGGACACCTGGC	0.602000													12	42					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56370494	56370494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56370494C>T	ENST00000301295.6	+	3	2157	c.1735C>T	c.(1735-1737)Cat>Tat	p.H579Y	NLRP4_ENST00000587891.1_Missense_Mutation_p.H504Y|NLRP4_ENST00000346986.5_Missense_Mutation_p.H579Y	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	579							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AGCTAACTTTCATATTATTGA	0.428000													27	61					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201438535	201438535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:201438535C>T	ENST00000357799.4	+	7	3564	c.3466C>T	c.(3466-3468)Cgt>Tgt	p.R1156C		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	1156					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						TGACAGTGTTCGTGAAGGTTT	0.363000													31	91					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9623815	9623815	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:9623815T>G	ENST00000310430.6	+	25	3646	c.3620T>G	c.(3619-3621)aTg>aGg	p.M1207R	TNKS_ENST00000518281.1_Missense_Mutation_p.M970R	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	1207	PARP catalytic.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		ATAGGAGGAATGTTTGGGGCC	0.408000													52	117					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139197070	139197070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139197070G>A	ENST00000274710.3	+	5	1226	c.1021G>A	c.(1021-1023)Gag>Aag	p.E341K		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	341	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCAGCAACGAGTTTAGCAG	0.587000													26	56					0	0	1	0	0
SPA17	53340	broad.mit.edu	37	11	124551353	124551353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124551353G>A	ENST00000532692.1	+	2	1644	c.223G>A	c.(223-225)Gag>Aag	p.E75K	SIAE_ENST00000525730.1_Intron|SPA17_ENST00000524614.1_3'UTR|SPA17_ENST00000227135.2_Missense_Mutation_p.E75K			Q15506	SP17_HUMAN	sperm autoantigenic protein 17	75					binding of sperm to zona pellucida|ciliary or flagellar motility|signal transduction|spermatogenesis	cytoplasm|flagellum|membrane|motile cilium|primary cilium	cAMP-dependent protein kinase regulator activity	p.E75Q(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	5	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0223)		TCATGCATTCGAGGTATGGTC	0.378000													30	50					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39158831	39158831	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39158831C>T	ENST00000359534.3	-	5	1673	c.1335G>A	c.(1333-1335)ggG>ggA	p.G445G		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	445					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						GGCTCTCCTCCCCTGCCAAGT	0.627000													10	24					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237983	140237983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140237983G>A	ENST00000307360.5	+	1	2350	c.2350G>A	c.(2350-2352)Ggg>Agg	p.G784R	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATGTGGACGGGGAAGATCA	0.522000													2	1					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41038970	41038970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41038970C>T	ENST00000399564.4	-	21	2532	c.2082G>A	c.(2080-2082)aaG>aaA	p.K694K	MROH2B_ENST00000506092.2_Silent_p.K249K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TGGTCAGGCTCTTTTTCCCAG	0.433000													24	66					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28608057	28608057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28608057C>T	ENST00000380982.4	-	15	1990	c.1909G>A	c.(1909-1911)Gtc>Atc	p.V637I	FLT3_ENST00000537084.1_Missense_Mutation_p.V637I|FLT3_ENST00000241453.7_Missense_Mutation_p.V637I			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	637	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGATTGAGACTCCTGTTTTG	0.453000			"""Mis, O"""		"""AML, ALL"""								22	260					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125405466	125405466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125405466G>A	ENST00000431078.1	+	13	2369	c.2005G>A	c.(2005-2007)Gac>Aac	p.D669N		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	669	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGCCGTGATCGACGGCTCTGA	0.632000													6	19					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140174721	140174721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140174721G>A	ENST00000526136.1	+	1	172	c.172G>A	c.(172-174)Gag>Aag	p.E58K	PCDHA2_ENST00000378132.1_Missense_Mutation_p.E58K|PCDHA2_ENST00000520672.2_Missense_Mutation_p.E58K|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGCTGGAGGAGCTGGTGCC	0.632000													76	135					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40652086	40652086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:40652086G>A	ENST00000342449.3	-	9	998	c.920C>T	c.(919-921)tCc>tTc	p.S307F	BRWD1_ENST00000333229.2_Missense_Mutation_p.S307F|BRWD1_ENST00000380800.3_Missense_Mutation_p.S307F	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AAATTTTAAGGATTCTAAATC	0.328000													16	54					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29651802	29651802	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:29651802C>T	ENST00000373779.3	+	29	4341	c.4212C>T	c.(4210-4212)acC>acT	p.T1404T	PTPRU_ENST00000428026.2_Silent_p.T1401T|PTPRU_ENST00000460170.2_Silent_p.T1408T|PTPRU_ENST00000323874.8_Silent_p.T1410T|PTPRU_ENST00000345512.3_Silent_p.T1414T|PTPRU_ENST00000356870.3_Silent_p.T1410T	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1414	Tyrosine-protein phosphatase 2.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CTGCCAAAACCCTCCGGAACT	0.612000													49	125					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842169	5842169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5842169C>T	ENST00000317037.2	+	1	626	c.604C>T	c.(604-606)Ctg>Ttg	p.L202L	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	202					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TATTTATGGTCTGATGGTTGC	0.468000													78	227					0	0	1	0	0
TRAV8-4	28682	broad.mit.edu	37	14	22363169	22363169	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22363169C>T	ENST00000390438.2	+	0	428																											AACCCTCAGCCCATATGAGCG	0.502000													24	73					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880283	74880283	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74880283C>T	ENST00000289575.5	+	5	909	c.514C>T	c.(514-516)Ccc>Tcc	p.P172S	SLCO2B1_ENST00000532236.1_Missense_Mutation_p.P56S|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.P28S|SLCO2B1_ENST00000526660.1_Intron|SLCO2B1_ENST00000341411.4_Intron|SLCO2B1_ENST00000454962.2_Intron|SLCO2B1_ENST00000531756.1_Intron|SLCO2B1_ENST00000428359.2_Missense_Mutation_p.P150S	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	172					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity	p.P172F(1)		breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	AGCCTCGGCCCCCTCCAATGG	0.562000													24	46					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	73000453	73000453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73000453G>A	ENST00000521978.1	+	25	3626	c.3626G>A	c.(3625-3627)gGa>gAa	p.G1209E	RIMS1_ENST00000401910.3_Intron|RIMS1_ENST00000538414.1_Intron|RIMS1_ENST00000348717.5_Intron|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000264839.7_Intron|RIMS1_ENST00000517960.1_Intron|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000518273.1_Intron|RIMS1_ENST00000491071.2_Intron|RIMS1_ENST00000425662.2_Intron	NM_014989.5	NP_055804.2	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1209					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GTCATTAGGGGAAAACATCCT	0.517000													4	23					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71044053	71044053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71044053C>T	ENST00000272367.2	-	4	536	c.460G>A	c.(460-462)Gga>Aga	p.G154R	CLEC4F_ENST00000426626.1_Missense_Mutation_p.G154R	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	154					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TTTAGAACTCCTTTTACCATC	0.478000													19	91					0	0	1	0	0
BOLL	66037	broad.mit.edu	37	2	198593232	198593232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:198593232C>T	ENST00000430004.1	-	12	1357	c.961G>A	c.(961-963)Gat>Aat	p.D321N	BOLL_ENST00000392296.4_3'UTR|BOLL_ENST00000282278.8_3'UTR|BOLL_ENST00000321801.7_3'UTR|AC011997.1_ENST00000409845.1_Intron			Q8N9W6	BOLL_HUMAN	boule-like RNA-binding protein	46					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(3)|prostate(1)	13						ACGCAAGGATCATTGGACAAG	0.423000													19	47					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564037	176564037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176564037C>T	ENST00000367662.3	+	3	2461	c.1297C>T	c.(1297-1299)Ctg>Ttg	p.L433L	PAPPA2_ENST00000367661.3_Silent_p.L433L	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	433					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GTCGACCGCCCTGCCACAAAG	0.562000													30	84					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156247733	156247733	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156247733T>A	ENST00000361813.5	-	3	424	c.280A>T	c.(280-282)Atc>Ttc	p.I94F	SMG5_ENST00000368267.4_Missense_Mutation_p.I94F	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	94					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					TTAGTCTTGATAAGCTGGATA	0.483000													77	201					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111141854	111141854	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111141854C>T	ENST00000360467.5	+	35	3576	c.3271_splice	c.e35+1	p.F1090_splice		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1090	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding	p.F1090F(1)		NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CTGGTGATTTCGGTGAGTGTT	0.507000													23	72					0	0	1	0	0
PTGS2	5743	broad.mit.edu	37	1	186646786	186646786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186646786G>A	ENST00000367468.5	-	5	770	c.634C>T	c.(634-636)Cat>Tat	p.H212Y	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	212					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	CTTACCCCATGGCCCAGCCCG	0.408000													47	105					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88420241	88420241	+	Silent	SNP	C	C	T	rs67229046		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88420241C>T	ENST00000394480.1	-	19	2724	c.2403G>A	c.(2401-2403)ttG>ttA	p.L801L	NTRK3_ENST00000355254.2_Silent_p.L801L|NTRK3_ENST00000357724.2_Silent_p.L807L|NTRK3_ENST00000360948.2_Silent_p.L815L|NTRK3_ENST00000557856.1_Silent_p.L793L	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	815	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCTTGATGTTCAACCGCTGCT	0.542000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			19	85					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	333603	333603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:333603G>A	ENST00000343164.4	-	10	1189	c.1137C>T	c.(1135-1137)ttC>ttT	p.F379F	SLC6A13_ENST00000445055.2_Silent_p.F287F	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	379					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CCATGAAGAAGAAACAGCAGG	0.597000													15	98					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258156	56258156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56258156C>T	ENST00000327216.2	-	1	715	c.691G>A	c.(691-693)Gag>Aag	p.E231K		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					TGCCTGCCCTCTGTAGAGCGA	0.408000													11	89					0	0	1	0	0
DPCD	25911	broad.mit.edu	37	10	103348040	103348040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103348040C>T	ENST00000416979.2	+	4	885	c.457C>T	c.(457-459)Cct>Tct	p.P153S	DPCD_ENST00000470165.1_Intron			Q9BVM2	DPCD_HUMAN	deleted in primary ciliary dyskinesia homolog (mouse)	0							protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(1)	5						CGGAAGTGACCCTCTGGAACG	0.612000													3	9					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14781671	14781671	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14781671C>T	ENST00000261170.3	-	20	2294	c.2157_splice	c.e20-1	p.V720_splice		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	720	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AGTAGGTACACCTGGAAGAAA	0.363000													14	72					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209807849	209807849	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209807849C>T	ENST00000391911.1	-	5	896	c.507G>A	c.(505-507)caG>caA	p.Q169Q	LAMB3_ENST00000356082.4_Silent_p.Q169Q|LAMB3_ENST00000367030.3_Silent_p.Q169Q	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	169	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		ACCGAACATCCTGCCAGCTCT	0.607000													23	97					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204804	56204804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56204804G>A	ENST00000361673.3	-	5	2828	c.2615C>T	c.(2614-2616)tCa>tTa	p.S872L	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	872							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CGTAGACACTGAAGTCTCAGA	0.423000													7	50					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113649088	113649088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113649088C>T	ENST00000297405.5	-	22	3917	c.3673G>A	c.(3673-3675)Ggt>Agt	p.G1225S	CSMD3_ENST00000455883.2_Missense_Mutation_p.G1121S|CSMD3_ENST00000343508.3_Missense_Mutation_p.G1185S|CSMD3_ENST00000352409.3_Missense_Mutation_p.G1225S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1225	Sushi 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CGTCGGCCACCACCAAGACAG	0.507000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	65					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33585684	33585684	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33585684C>T	ENST00000404816.2	+	27	4374	c.4021C>T	c.(4021-4023)Caa>Taa	p.Q1341*	LTBP1_ENST00000404525.1_Nonsense_Mutation_p.Q962*|LTBP1_ENST00000402934.1_Nonsense_Mutation_p.Q960*|LTBP1_ENST00000272273.5_Nonsense_Mutation_p.Q239*|LTBP1_ENST00000390003.4_Nonsense_Mutation_p.Q1016*|LTBP1_ENST00000418533.2_Nonsense_Mutation_p.Q973*|LTBP1_ENST00000407925.1_Nonsense_Mutation_p.Q1015*|LTBP1_ENST00000354476.3_Nonsense_Mutation_p.Q1342*			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1341					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGATGTAGATCAACCCAAAGA	0.403000													26	78					0	0	1	0	0
TBCCD1	55171	broad.mit.edu	37	3	186272334	186272334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186272334G>A	ENST00000424280.1	-	6	1732	c.1253C>T	c.(1252-1254)cCt>cTt	p.P418L	TBCCD1_ENST00000446782.1_Missense_Mutation_p.P322L|TBCCD1_ENST00000338733.5_Missense_Mutation_p.P418L	NM_001134415.1	NP_001127887.1	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	418	C-CAP/cofactor C-like.				cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		TGTATGAAAAGGGGCAAAAGT	0.468000													13	41					0	0	1	0	0
BATF3	55509	broad.mit.edu	37	1	212860311	212860311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:212860311C>T	ENST00000243440.1	-	3	428	c.206G>A	c.(205-207)aGc>aAc	p.S69N	BATF3_ENST00000478275.1_5'UTR	NM_018664.2	NP_061134.1	Q9NR55	BATF3_HUMAN	basic leucine zipper transcription factor, ATF-like 3	69	Leucine-zipper.				transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0046)|all cancers(67;0.00785)|GBM - Glioblastoma multiforme(131;0.0731)|Epithelial(68;0.0781)		TTGCTCCAGGCTCTCATATTC	0.557000													69	136					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118764316	118764316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:118764316G>A	ENST00000376300.2	-	3	370	c.233C>T	c.(232-234)tCt>tTt	p.S78F	CCDC93_ENST00000319432.5_Missense_Mutation_p.S78F|AC009303.1_ENST00000590516.1_RNA|AC009303.1_ENST00000588042.1_RNA	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	78										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						ACCTATCGTAGAGTTTTCTTG	0.378000													13	34					0	0	1	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70968663	70968663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70968663C>T	ENST00000359655.4	+	15	2293	c.2233C>T	c.(2233-2235)Cca>Tca	p.P745S		NM_003171.3	NP_003162.2	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 (S. cerevisiae)	745	Interaction with HBXIP, important for protein stability.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding	p.P745A(1)		NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACTCCTCACTCCAGACATGCT	0.502000													17	50					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24185170	24185170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:24185170G>A	ENST00000396671.2	-	8	908	c.560C>T	c.(559-561)gCc>gTc	p.A187V	THRB_ENST00000280696.5_Missense_Mutation_p.A202V|THRB_ENST00000356447.4_Missense_Mutation_p.A187V|THRB_ENST00000416420.1_Missense_Mutation_p.A187V	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	187					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	CTTCCTCTTGGCCAGCCTCTT	0.572000													6	83					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108117798	108117798	+	Missense_Mutation	SNP	C	C	T	rs138398778		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108117798C>T	ENST00000278616.4	+	8	1394	c.1009C>T	c.(1009-1011)Cgt>Tgt	p.R337C	ATM_ENST00000452508.2_Missense_Mutation_p.R337C	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	337			R -> C (in a colorectal adenocarcinoma sample; somatic mutation).|R -> H (in a colorectal adenocarcinoma sample; somatic mutation).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R337C(3)|p.R337S(2)|p.F336_A340del(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTCAGGATTTCGTAATATTGC	0.323000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			16	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593759	179593759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179593759C>T	ENST00000589042.1	-	65	19230	c.19006G>A	c.(19006-19008)Gat>Aat	p.D6336N	TTN_ENST00000342992.6_Missense_Mutation_p.D5092N|TTN_ENST00000591111.1_Missense_Mutation_p.D6019N|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6019	Ig-like 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGACATTATCATCTTCATCA	0.408000													6	21					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113403696	113403696	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113403696C>T	ENST00000228928.7	+	12	2730	c.2551C>T	c.(2551-2553)Caa>Taa	p.Q851*	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	851	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						GGAGGCATGTCAACAGGAGCG	0.582000													6	20					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151509257	151509257	+	Silent	SNP	G	G	A	rs146901365		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:151509257G>A	ENST00000535741.1	-	40	6746	c.6273C>T	c.(6271-6273)tcC>tcT	p.S2091S	LRBA_ENST00000510413.1_Silent_p.S2091S|LRBA_ENST00000507224.1_Silent_p.S2091S|LRBA_ENST00000357115.3_Silent_p.S2102S			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2102						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AATAGAGTTCGGAGGAGGTGA	0.468000													20	199					0	0	1	0	0
MYLPF	29895	broad.mit.edu	37	16	30387211	30387211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30387211C>T	ENST00000322861.7	+	2	155	c.74C>T	c.(73-75)aCt>aTt	p.T25I		NM_013292.3	NP_037424.2	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast skeletal muscle	25	EF-hand 1.				skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle			large_intestine(2)|lung(4)	6			Colorectal(24;0.193)			TTCGACCAGACTCAGATCCAG	0.597000													5	27					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62203493	62203493	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62203493G>A	ENST00000467148.1	-	1	315	c.246C>T	c.(244-246)ccC>ccT	p.P82P	HELZ2_ENST00000479540.1_5'UTR	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		AGAGTCCCGGGGGTGGGGAAC	0.632000													5	15					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102589725	102589725	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:102589725G>A	ENST00000251808.3	+	7	1319	c.981G>A	c.(979-981)gcG>gcA	p.A327A	GRHL2_ENST00000395927.1_Silent_p.A311A	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	327						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			AGCATACGGCGAAGCAGAGGG	0.498000													5	40					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125516860	125516860	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:125516860C>T	ENST00000241305.3	-	12	1940	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	596					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TAGCTGAAATCGTTCAGACCT	0.493000													41	99					0	0	1	0	0
PRPF31	26121	broad.mit.edu	37	19	54627968	54627968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54627968C>T	ENST00000321030.4	+	8	1137	c.788C>T	c.(787-789)tCg>tTg	p.S263L	AC012314.8_ENST00000452097.1_RNA|PRPF31_ENST00000498612.1_3'UTR|PRPF31_ENST00000391755.1_Missense_Mutation_p.S263L|PRPF31_ENST00000419967.1_Missense_Mutation_p.S263L	NM_015629.3	NP_056444.3	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31	263	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)|urinary_tract(3)	12	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCGGGCTTCTCGTCTACCTCA	0.672000													40	56					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20180764	20180764	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20180764G>A	ENST00000400331.5	-	7	2672	c.2364C>T	c.(2362-2364)gcC>gcT	p.A788A	MACC1_ENST00000332878.4_Silent_p.A788A|MACC1_ENST00000589011.1_Silent_p.A788A	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	788					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						GAAAATCATAGGCAGGTTTCC	0.358000													27	79					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13793832	13793832	+	Silent	SNP	C	C	T	rs112594597		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13793832C>T	ENST00000265104.4	-	49	8120	c.8016G>A	c.(8014-8016)acG>acA	p.T2672T		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2672	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTATCTCATTCGTAACCTACA	0.423000									Kartagener syndrome				20	76					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50683114	50683114	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:50683114G>A	ENST00000008391.3	+	2	553	c.325G>A	c.(325-327)Gag>Aag	p.E109K		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	109							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					CCACCACGGGGAGCCCACCGA	0.627000													17	111					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057770	63057770	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63057770C>T	ENST00000332793.6	+	1	135	c.133C>T	c.(133-135)Cct>Tct	p.P45S	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_5'UTR	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	45						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGCAGCCATTCCTGGTCATCG	0.443000													39	81					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095870	167095870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167095870G>A	ENST00000361200.2	+	6	1668	c.1502G>A	c.(1501-1503)aGa>aAa	p.R501K	DUSP27_ENST00000443333.1_Missense_Mutation_p.R501K|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.R501K			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	501					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AAGAGCAAGAGAGAGGAGGCG	0.607000													19	40					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16230351	16230351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16230351C>T	ENST00000399408.2	+	30	4347	c.4172C>T	c.(4171-4173)tCg>tTg	p.S1391L	ABCC1_ENST00000349029.5_Missense_Mutation_p.S1266L|ABCC1_ENST00000345148.5_Missense_Mutation_p.S1381L|ABCC1_ENST00000346370.5_Missense_Mutation_p.S1325L|ABCC1_ENST00000399410.3_Missense_Mutation_p.S1381L|ABCC1_ENST00000351154.5_Missense_Mutation_p.S1322L			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1381	ABC transporter 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTTTTGTTTTCGGGTTCCCTC	0.562000													9	43					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23896924	23896924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23896924C>T	ENST00000355349.3	-	16	1920	c.1758G>A	c.(1756-1758)gtG>gtA	p.V586V		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	586	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGTTGTAGTCCACGATGCCGG	0.532000													26	70					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73490351	73490351	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73490351C>T	ENST00000224721.6	+	30	3725	c.3720C>T	c.(3718-3720)gaC>gaT	p.D1240D	C10orf105_ENST00000398786.2_Intron	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1235	Cadherin 12.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						AAGCCACAGACCGAGACTCTG	0.617000													9	43					0	0	1	0	0
FOXRED1	55572	broad.mit.edu	37	11	126143291	126143291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:126143291C>T	ENST00000263578.5	+	4	552	c.478C>T	c.(478-480)Ctc>Ttc	p.L160F	FOXRED1_ENST00000442061.2_5'UTR|FOXRED1_ENST00000532125.1_Missense_Mutation_p.L146F|FOXRED1_ENST00000534011.1_3'UTR	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	160						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		CTCGGGCTACCTCTTGCTGGC	0.567000													8	129					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107782025	107782025	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:107782025C>T	ENST00000311955.3	-	1	448	c.394G>A	c.(394-396)Gag>Aag	p.E132K		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	132					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GCATCCCTCTCGTACCTGTGG	0.542000													41	87					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147985774	147985774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:147985774G>A	ENST00000370460.2	+	9	1862	c.1383G>A	c.(1381-1383)agG>agA	p.R461R	AFF2_ENST00000286437.5_Silent_p.R102R|AFF2_ENST00000370458.1_Silent_p.R422R|AFF2_ENST00000370457.5_Silent_p.R428R|AFF2_ENST00000342251.3_Silent_p.R428R	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	461					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CAAAACCTAGGAATAATCCTG	0.323000													69	37					0	0	1	0	0
STIM2	57620	broad.mit.edu	37	4	27009158	27009158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:27009158C>T	ENST00000382009.3	+	8	1513	c.1246C>T	c.(1246-1248)Cgc>Tgc	p.R416C	STIM2_ENST00000237364.5_Missense_Mutation_p.R416C|STIM2_ENST00000467011.1_Missense_Mutation_p.R329C|STIM2_ENST00000467087.1_Missense_Mutation_p.R329C|STIM2_ENST00000465503.1_Missense_Mutation_p.R329C|STIM2_ENST00000412829.2_Missense_Mutation_p.R416C	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	329					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				cttcTAGGTTCGCATGGCTCT	0.383000													5	43					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42917072	42917072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42917072G>A	ENST00000316161.4	-	1	561	c.237C>T	c.(235-237)ttC>ttT	p.F79F	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.F79F|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	79					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity	p.F79F(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		GGTCCATGACGAAGGTGAAGT	0.483000													19	47					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42059249	42059249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42059249C>T	ENST00000219905.7	+	24	9150	c.8969C>T	c.(8968-8970)gCc>gTc	p.A2990V	MGA_ENST00000570161.1_Missense_Mutation_p.A2990V|MGA_ENST00000545763.1_Missense_Mutation_p.A2781V|MGA_ENST00000389936.4_Missense_Mutation_p.A2951V|MGA_ENST00000566586.1_Missense_Mutation_p.A2781V	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2951						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CCAAAGTTGGCCCCTCTAGGT	0.512000													20	50					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116605974	116605974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116605974C>T	ENST00000369248.4	+	10	1581	c.1246C>T	c.(1246-1248)Cgc>Tgc	p.R416C	FAM160B1_ENST00000369250.3_Missense_Mutation_p.R416C	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	416										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						TCTGCTTCATCGCATCGTTCG	0.448000													89	206					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47117421	47117421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:47117421G>A	ENST00000562435.1	-	9	1673	c.1289C>T	c.(1288-1290)aCc>aTc	p.T430I	NETO2_ENST00000303155.5_Missense_Mutation_p.T423I	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2	430						integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				GCGGGAGGCGGTGGAGGAGCG	0.527000										HNSCC(25;0.065)			39	123					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123780052	123780052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123780052G>A	ENST00000223642.1	-	13	1614	c.1585C>T	c.(1585-1587)Cca>Tca	p.P529S		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	529					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TGTGTTACTGGAATGTTTATA	0.388000													20	60					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439377	110439377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110439377C>T	ENST00000378402.5	+	25	3096	c.2992C>T	c.(2992-2994)Ctt>Ttt	p.L998F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	998					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAAGCAGAATCTTCTACAGGT	0.473000										HNSCC(38;0.096)			12	20					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54159124	54159124	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:54159124A>G	ENST00000404125.1	-	10	1219	c.1164T>C	c.(1162-1164)ctT>ctC	p.L388L	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	388					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CTTGATCAGTAAGCTTGTGGC	0.443000													30	54					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072199	17072199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17072199G>A	ENST00000359963.3	-	1	1501	c.1242C>T	c.(1240-1242)gcC>gcT	p.A414A		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	414					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCATTTCTGTGGCCCCAGCTC	0.547000													25	60					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10420946	10420946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10420946C>T	ENST00000360273.2	-	9	1461	c.1023G>A	c.(1021-1023)gtG>gtA	p.V341V	ATP2B2_ENST00000397077.1_Intron|ATP2B2_ENST00000383800.4_Intron|ATP2B2_ENST00000352432.4_Silent_p.V341V|ATP2B2_ENST00000343816.4_Intron	NM_001001331.2	NP_001001331.1	Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	341					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GGCTGGCGTCCACATTGCCAT	0.517000													13	31					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33293903	33293903	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:33293903C>T	ENST00000280979.4	+	13	7054	c.6884C>T	c.(6883-6885)cCc>cTc	p.P2295L	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	2295					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GCATTGCATCCCAGCCCCAAA	0.433000													31	86					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17446125	17446125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17446125C>T	ENST00000400588.1	-	7	1429	c.1322G>A	c.(1321-1323)aGg>aAg	p.R441K		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	441										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				ATTGATGACCCTGTTGTTTCT	0.557000													10	37					0	0	1	0	0
CD300LB	124599	broad.mit.edu	37	17	72522001	72522001	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72522001T>A	ENST00000392621.1	-	2	371	c.367A>T	c.(367-369)Acg>Tcg	p.T123S	CD300LB_ENST00000314401.3_Missense_Mutation_p.T123S	NM_174892.2	NP_777552.2	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	86						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(1)	21						ACAGTGAACGTGCGGTCTTTC	0.522000													66	136					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676399	123676399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123676399G>A	ENST00000309154.2	-	1	696	c.659C>T	c.(658-660)tCt>tTt	p.S220F		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CAGGATGGTAGAAATTATGTA	0.488000													12	28					0	0	1	0	0
ICAM5	7087	broad.mit.edu	37	19	10403533	10403533	+	Missense_Mutation	SNP	C	C	T	rs140852122		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10403533C>T	ENST00000221980.4	+	5	1270	c.1207C>T	c.(1207-1209)Cgt>Tgt	p.R403C		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	403					cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CGCAGAGCTTCGTGTCCTATG	0.602000													14	59					0	0	1	0	0
ZNF597	146434	broad.mit.edu	37	16	3486680	3486680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3486680G>A	ENST00000301744.4	-	4	1254	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	LA16c-306E5.2_ENST00000575785.1_RNA	NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						acactgtaagggcttgaattt	0.463000													11	17					0	0	1	0	0
KLK12	43849	broad.mit.edu	37	19	51535261	51535261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51535261G>A	ENST00000525263.1	-	3	447	c.328C>T	c.(328-330)Cgg>Tgg	p.R110W	CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000319590.4_Missense_Mutation_p.R110W|KLK12_ENST00000250351.4_Missense_Mutation_p.R110W|KLK12_ENST00000250352.11_Intron|KLK12_ENST00000529888.1_Intron			Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	110	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		CGCAGCAGCCGGAGGTCGTGC	0.682000													10	20					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324495	152324495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152324495G>A	ENST00000388718.5	-	3	5839	c.5767C>T	c.(5767-5769)Cat>Tat	p.H1923Y	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1923							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCTGTCCATGAGTAGTTTGG	0.517000													63	263					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118306879	118306879	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118306879C>T	ENST00000369221.2	+	3	148	c.120C>T	c.(118-120)ccC>ccT	p.P40P	PNLIP_ENST00000470562.1_3'UTR	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	40					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CGGAAAGACCCCTCCATATAT	0.438000													22	107					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131191231	131191231	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:131191231C>T	ENST00000337057.3	-	15	2260	c.2079G>A	c.(2077-2079)aaG>aaA	p.K693K	EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000528282.1_Intron|EPB41L2_ENST00000525193.1_Intron|EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000527659.1_Silent_p.K623K|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000445890.2_Intron|EPB41L2_ENST00000368128.2_Silent_p.K693K|EPB41L2_ENST00000527411.1_Silent_p.K623K|EPB41L2_ENST00000530481.1_Silent_p.K623K|EPB41L2_ENST00000531410.1_Intron|EPB41L2_ENST00000529208.1_Silent_p.K623K|EPB41L2_ENST00000524581.1_Silent_p.K71K	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	693					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CTGCCCGCTTCTTCTCCTCCA	0.408000													32	40					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47605684	47605684	+	Splice_Site	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47605684T>G	ENST00000273857.4	-	20	2541	c.2540_splice	c.e20-1	p.R848_splice	CORIN_ENST00000502252.1_Splice_Site_p.R781_splice|CORIN_ENST00000505909.1_Splice_Site_p.R811_splice|CORIN_ENST00000508498.1_Splice_Site_p.R709_splice	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	848	Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GCATTCTCTCTCCTAAAATTA	0.353000													4	41					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1801497	1801497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1801497G>A	ENST00000340107.4	+	4	659	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K	FGFR3_ENST00000481110.2_Missense_Mutation_p.E135K|FGFR3_ENST00000440486.2_Missense_Mutation_p.E135K|FGFR3_ENST00000412135.2_Missense_Mutation_p.E135K|FGFR3_ENST00000260795.2_Missense_Mutation_p.E135K|FGFR3_ENST00000352904.1_Missense_Mutation_p.E135K	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	135					bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGGAGATGACGAAGACGGGGA	0.682000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				5	42					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610231	47610231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47610231G>A	ENST00000371891.3	+	8	938	c.907G>A	c.(907-909)Ggg>Agg	p.G303R	CYP4A22_ENST00000371890.3_Intron|CYP4A22_ENST00000294337.3_Missense_Mutation_p.G303R|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000485117.1_Intron	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	303						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GATGGAGAATGGGAGCATCTT	0.537000													23	156					0	0	1	0	0
DAPP1	27071	broad.mit.edu	37	4	100738117	100738117	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100738117C>T	ENST00000296414.7	+	1	128	c.47C>T	c.(46-48)cCc>cTc	p.P16L	DAPP1_ENST00000512369.1_Missense_Mutation_p.P16L			Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and 3-phosphoinositides	16					signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity			endometrium(1)|kidney(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		ACCCAGGATCCCTCAGATCTG	0.552000													4	12					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7249425	7249425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7249425G>A	ENST00000266542.4	-	6	1118	c.1026C>T	c.(1024-1026)ctC>ctT	p.L342L	C1RL_ENST00000545280.1_Intron|C1RL_ENST00000544702.1_3'UTR|C1RL_ENST00000504702.2_Intron	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	342	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GCAGCTCCAGGAGGGCGATGT	0.602000													22	42					0	0	1	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48716111	48716111	+	Silent	SNP	G	G	A	rs34283811		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48716111G>A	ENST00000294129.2	-	12	1970	c.1851C>T	c.(1849-1851)ttC>ttT	p.F617F	NCKIPSD_ENST00000416649.2_Silent_p.F610F|NCKIPSD_ENST00000341520.4_Silent_p.F617F	NM_016453.2	NP_057537.1	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain	617					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGTCCTGCAGGAACTTGAGGA	0.572000													49	93					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66416266	66416266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:66416266G>A	ENST00000395625.2	-	3	311	c.47C>T	c.(46-48)tCc>tTc	p.S16F	MEGF11_ENST00000395614.1_5'UTR|MEGF11_ENST00000409699.2_Silent_p.I57I|MEGF11_ENST00000360698.4_Silent_p.I57I|MEGF11_ENST00000288745.3_Missense_Mutation_p.S16F|MEGF11_ENST00000422354.1_Silent_p.I57I			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	0						basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						ACCAGTTGAGGATGTCTGTGC	0.532000													17	92					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157931190	157931190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157931190G>A	ENST00000389413.3	-	7	1031	c.928C>T	c.(928-930)Ctc>Ttc	p.L310F	PTPRN2_ENST00000409483.1_Missense_Mutation_p.L272F|PTPRN2_ENST00000404321.2_Missense_Mutation_p.L333F|PTPRN2_ENST00000389416.4_Missense_Mutation_p.L293F|PTPRN2_ENST00000389418.4_Missense_Mutation_p.L310F	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	310						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TCCTTCAGGAGGGTATGAATC	0.617000													23	61					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1078005	1078005	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1078005C>T	ENST00000264930.5	-	12	1615	c.1572G>A	c.(1570-1572)acG>acA	p.T524T		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	524					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GCGGTGCCCCCGTGAGGCTCT	0.692000													4	15					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28864346	28864346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28864346C>T	ENST00000373833.6	+	13	1378	c.1093C>T	c.(1093-1095)Cgt>Tgt	p.R365C	RCC1_ENST00000373831.3_Missense_Mutation_p.R396C|RCC1_ENST00000373832.1_Missense_Mutation_p.R365C|RCC1_ENST00000398958.2_Missense_Mutation_p.R365C			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	365					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		TCTTGCAGGTCGTGTTTTCGC	0.592000													10	13					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4281431	4281431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4281431G>A	ENST00000404826.2	+	43	6276	c.6137G>A	c.(6136-6138)gGg>gAg	p.G2046E	SDK1_ENST00000389531.3_Missense_Mutation_p.G2026E|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2046					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTAGGAAAGGGGATCTCCACC	0.607000													8	30					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131976126	131976126	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131976126G>A	ENST00000356920.5	+	1	245	c.151G>A	c.(151-153)Gac>Aac	p.D51N	PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_Missense_Mutation_p.D51N	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	51							ATP binding										AGACCACGACGACTCTGCTAT	0.597000													24	340					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163819	32163819	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32163819G>A	ENST00000564145.1	-	0	15																											GCGGAGCTGGGAGTTGATGTA	0.527000													7	69					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48267725	48267725	+	Missense_Mutation	SNP	G	G	A	rs145307365		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48267725G>A	ENST00000225964.5	-	35	2532	c.2414C>T	c.(2413-2415)cCt>cTt	p.P805L		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	805	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GGGGGGACCAGGCTCACCACG	0.622000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						6	79					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791225	95791225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95791225C>T	ENST00000260766.3	+	2	1056	c.422C>T	c.(421-423)cCt>cTt	p.P141L	PLCE1_ENST00000371380.2_Missense_Mutation_p.P141L	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	141					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				ACTGGAATTCCTTCTCCACTG	0.413000													32	75					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84784977	84784977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:84784977G>A	ENST00000389394.3	+	11	1858	c.1721G>A	c.(1720-1722)gGa>gAa	p.G574E	DNAH6_ENST00000237449.6_Missense_Mutation_p.G574E|DNAH6_ENST00000398278.2_Missense_Mutation_p.G574E	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	574	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						AAACTTGAAGGAAAAACCTGT	0.358000													23	148					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326351	152326351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152326351C>T	ENST00000388718.5	-	3	3983	c.3911G>A	c.(3910-3912)gGa>gAa	p.G1304E	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1304							calcium ion binding|structural molecule activity	p.G1304A(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AACTGTGGATCCTGACTTTGG	0.478000													68	287					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29782300	29782300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:29782300C>T	ENST00000375398.2	-	23	4311	c.3862G>A	c.(3862-3864)Gtg>Atg	p.V1288M	SVIL_ENST00000355867.4_Missense_Mutation_p.V1288M|SVIL_ENST00000375400.3_Missense_Mutation_p.V862M|SVIL_ENST00000535393.1_Missense_Mutation_p.V202M|SVIL_ENST00000538146.1_Missense_Mutation_p.V80M			O95425	SVIL_HUMAN	supervillin	1288					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				ACAGTGAGCACCGTTTCGTGC	0.398000													16	32					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1058699	1058699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1058699C>T	ENST00000263094.6	+	38	5463	c.5232C>T	c.(5230-5232)ttC>ttT	p.F1744F	ABCA7_ENST00000435683.2_Silent_p.F1606F|ABCA7_ENST00000433129.1_Silent_p.F1744F	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1744					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCCCTCTTCCTTCTCTTCA	0.572000													42	115					0	0	1	0	0
PIWIL4	143689	broad.mit.edu	37	11	94341758	94341758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94341758C>T	ENST00000299001.6	+	15	2060	c.1849C>T	c.(1849-1851)Ctg>Ttg	p.L617L	RP11-867G2.8_ENST00000537874.1_RNA|RP11-867G2.8_ENST00000536540.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	617	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GTTAAAGTCCCTGATGGTGGT	0.403000													18	183					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735322	13735322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13735322G>A	ENST00000265104.4	-	68	11783	c.11679C>T	c.(11677-11679)ttC>ttT	p.F3893F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3893					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGGTGAACAGGAATTTGTGCT	0.433000									Kartagener syndrome				30	67					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80626663	80626663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:80626663G>A	ENST00000307624.3	-	14	1516	c.1488C>T	c.(1486-1488)ctC>ctT	p.L496L	ACOT12_ENST00000508234.1_5'UTR	NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	496	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TAGCATGGATGAGAAATCCGG	0.433000													6	69					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16475435	16475435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:16475435G>A	ENST00000334133.4	-	3	527	c.255C>T	c.(253-255)ttC>ttT	p.F85F	RFTN1_ENST00000432519.1_Silent_p.F49F	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	85						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						TGGGCTGCACGAAGGGGTGCA	0.642000													36	164					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75266120	75266120	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75266120C>T	ENST00000325680.7	+	5	4244	c.4120C>T	c.(4120-4122)Cga>Tga	p.R1374*	YLPM1_ENST00000238571.3_Nonsense_Mutation_p.R1179*|YLPM1_ENST00000552421.1_Intron	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GTTGAGGATTCGAGAGTATCC	0.463000													46	202					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11580895	11580895	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11580895C>T	ENST00000294484.6	+	10	2490	c.2352C>T	c.(2350-2352)atC>atT	p.I784I	PTCHD2_ENST00000389575.3_Silent_p.I784I	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	784					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCTCCTGCATCACCTGTTCAG	0.637000													7	9					0	0	1	0	0
NPPA	4878	broad.mit.edu	37	1	11907192	11907192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11907192C>T	ENST00000376480.3	-	2	526	c.428G>A	c.(427-429)gGa>gAa	p.G143E	NPPA-AS1_ENST00000400892.2_RNA|NPPA_ENST00000376476.1_Missense_Mutation_p.G93E|NPPA-AS1_ENST00000446542.1_RNA	NM_006172.3	NP_006163.1	P01160	ANF_HUMAN	natriuretic peptide A	143					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACAGCCCAGTCCGCTCTGGGC	0.592000													128	301					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45671561	45671561	+	Silent	SNP	G	G	A	rs148926071		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45671561G>A	ENST00000270172.3	-	9	1197	c.714C>T	c.(712-714)ttC>ttT	p.F238F	DNMT3L_ENST00000418993.1_Silent_p.F238F	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	238					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding	p.F238F(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		ACACAAGATCGAAGGGTCCCC	0.652000													9	36					0	0	1	0	0
GPR27	2850	broad.mit.edu	37	3	71803825	71803825	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:71803825C>T	ENST00000304411.2	+	1	625	c.625C>T	c.(625-627)Cac>Tac	p.H209Y	EIF4E3_ENST00000421769.2_5'UTR	NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	209						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CTTCTTCATCCACGACCGCCG	0.761000													6	6					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154395491	154395491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154395491G>A	ENST00000435029.4	+	1	2232	c.2072G>A	c.(2071-2073)aGa>aAa	p.R691K		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	691	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAACTTGAAAGAAACTTCCAG	0.443000													45	93					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68747534	68747534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68747534C>T	ENST00000309106.3	-	1	921	c.922G>A	c.(922-924)Ggt>Agt	p.G308S		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	308						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTCTCCCCACCTTCCAGCTCG	0.672000													21	66					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81251698	81251698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81251698G>A	ENST00000555265.1	-	15	2127	c.1752C>T	c.(1750-1752)tcC>tcT	p.S584S	CEP128_ENST00000281129.3_Silent_p.S584S			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	584						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TGGTATCCAGGGAATTCTTAA	0.438000													34	106					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17531718	17531718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17531718C>T	ENST00000375471.4	+	1	98	c.6C>T	c.(4-6)gcC>gcT	p.A2A		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	2					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	ACAGGATGGCCCCAAAGAGAG	0.587000													12	24					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97920544	97920544	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97920544C>T	ENST00000534948.1	+	0	5320							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		ACCATAATTACCAAGGAAAAG	0.363000													7	8					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214814107	214814107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:214814107C>T	ENST00000366955.3	+	12	2594	c.2426C>T	c.(2425-2427)tCa>tTa	p.S809L		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	809					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGCATGCCTTCAGAGAGGAGT	0.388000													17	42					0	0	1	0	0
UBXN2B	137886	broad.mit.edu	37	8	59345768	59345768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:59345768C>T	ENST00000399598.2	+	4	511	c.389C>T	c.(388-390)tCt>tTt	p.S130F	UBXN2B_ENST00000522978.1_3'UTR	NM_001077619.1	NP_001071087.1	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	130						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13						TGTAAGCGGTCTGAATATATC	0.308000													81	206					0	0	1	0	0
PLA2G2E	30814	broad.mit.edu	37	1	20249129	20249129	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20249129G>A	ENST00000375116.3	-	2	217	c.160C>T	c.(160-162)Ccg>Tcg	p.P54S		NM_014589.1	NP_055404.1	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE	54					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity	p.P54S(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTCCACCGGCCAGTGGGAG	0.612000													6	89					0	0	1	0	0
LCE2D	353141	broad.mit.edu	37	1	152636718	152636718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152636718C>T	ENST00000368784.1	+	2	192	c.137C>T	c.(136-138)tCc>tTc	p.S46F		NM_178430.2	NP_848517.1	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	46	Cys-rich.				keratinization					large_intestine(1)|lung(7)|prostate(2)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCAGTCTCTTCCTGCTGTGGT	0.632000													79	190					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155203411	155203411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155203411C>T	ENST00000460012.1	-	22	2975	c.2618G>A	c.(2617-2619)cGa>cAa	p.R873Q	PLCH1_ENST00000414191.1_Missense_Mutation_p.R873Q|PLCH1_ENST00000340059.7_Missense_Mutation_p.R911Q|PLCH1_ENST00000334686.6_Missense_Mutation_p.R873Q|PLCH1_ENST00000447496.2_Missense_Mutation_p.R911Q|PLCH1_ENST00000494598.1_Missense_Mutation_p.R891Q			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	911					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCAATGGATCGCTTCCGTAC	0.458000													17	64					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685369	100685369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100685369C>T	ENST00000306151.4	+	3	10736	c.10672C>T	c.(10672-10674)Cca>Tca	p.P3558S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3558	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTTCATCTCCAGCAACTCT	0.483000													45	398					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242151573	242151573	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242151573C>T	ENST00000274979.8	+	16	1891	c.1788C>T	c.(1786-1788)ttC>ttT	p.F596F	ANO7_ENST00000402430.3_Silent_p.F595F	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	596						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						TCTTCCAGTTCGTCAACTTCT	0.582000													41	77					0	0	1	0	0
WFDC11	259239	broad.mit.edu	37	20	44278037	44278037	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44278037C>T	ENST00000356562.2	-	4	323	c.100_splice	c.e4-1	p.R34_splice	WFDC11_ENST00000324384.3_Splice_Site_p.R34_splice			Q8NEX6	WFD11_HUMAN	WAP four-disulfide core domain 11	34						extracellular region				endometrium(1)|lung(4)	5		Myeloproliferative disorder(115;0.0122)				ACAATTCCTTCCCTGAAATTG	0.388000													41	139					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186292914	186292914	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186292914G>A	ENST00000367478.3	-	43	6497	c.6201C>T	c.(6199-6201)gcC>gcT	p.A2067A		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	2067					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GTGCTCGAGGGGCCTGTCTTT	0.517000			T	NTRK1	papillary thyroid								63	131					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30860294	30860294	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30860294C>T	ENST00000324771.8	+	10	1622	c.1074C>T	c.(1072-1074)ctC>ctT	p.L358L	DDR1_ENST00000418800.2_Silent_p.L358L|DDR1_ENST00000361741.4_Silent_p.L89L|DDR1_ENST00000376570.4_Silent_p.L358L|DDR1_ENST00000376569.3_Silent_p.L358L|DDR1_ENST00000376567.2_Silent_p.L358L|DDR1_ENST00000452441.1_Silent_p.L358L|DDR1_ENST00000376568.3_Silent_p.L358L|DDR1_ENST00000508312.1_Silent_p.L376L|DDR1_ENST00000454612.2_Silent_p.L358L|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000513240.1_Silent_p.L358L|DDR1_ENST00000376575.3_Silent_p.L358L			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	358					cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CCTGGTTACTCTTCAGCGAAA	0.587000													13	121					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38988326	38988326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38988326G>A	ENST00000302328.3	-	2	538	c.340C>T	c.(340-342)Cct>Tct	p.P114S	SCN11A_ENST00000456224.3_Missense_Mutation_p.P114S|SCN11A_ENST00000444237.2_Missense_Mutation_p.P114S|SCN11A_ENST00000450244.1_Missense_Mutation_p.P114S	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	114					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GAATTGAAAGGCCCAAAAATG	0.373000													36	84					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370697	240370697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240370697C>T	ENST00000319653.9	+	5	2815	c.2585C>T	c.(2584-2586)cCt>cTt	p.P862L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	862	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCACCTCTGCCTTGCACAGAG	0.572000													29	127					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35545003	35545003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35545003C>T	ENST00000536438.1	-	11	1349	c.1034G>A	c.(1033-1035)gGa>gAa	p.G345E	FKBP5_ENST00000540787.1_Missense_Mutation_p.G166E|FKBP5_ENST00000357266.4_Missense_Mutation_p.G345E|FKBP5_ENST00000539068.1_Missense_Mutation_p.G345E	NM_001145775.1	NP_001139247.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	345					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						ACTGTCCAGTCCAAGGGCCTA	0.433000													51	174					0	0	1	0	0
PAQR5	54852	broad.mit.edu	37	15	69689814	69689814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:69689814G>A	ENST00000340965.3	+	7	1188	c.520G>A	c.(520-522)Gaa>Aaa	p.E174K	PAQR5_ENST00000395407.2_Missense_Mutation_p.E174K|RP11-253M7.1_ENST00000560539.1_RNA|PAQR5_ENST00000561153.1_Missense_Mutation_p.E174K|RP11-253M7.1_ENST00000558617.1_RNA	NM_001104554.1	NP_001098024.1	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	174					cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|skin(1)	11						TAGGTTTCTTGAAATCCAGAA	0.502000													65	88					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712539	140712539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140712539C>T	ENST00000517417.1	+	1	2288	c.2288C>T	c.(2287-2289)tCg>tTg	p.S763L	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.S763L	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCGGACTCGCGGAAGAGC	0.592000													86	188					0	0	1	0	0
SEMA4C	54910	broad.mit.edu	37	2	97527334	97527334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97527334G>A	ENST00000305476.5	-	14	1786	c.1654C>T	c.(1654-1656)Ctc>Ttc	p.L552F		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	552					muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						CTGCCACGGAGGTTGCAGATG	0.562000													28	130					0	0	1	0	0
THAP4	51078	broad.mit.edu	37	2	242573389	242573389	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242573389G>A	ENST00000407315.1	-	2	614	c.183C>T	c.(181-183)acC>acT	p.T61T		NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	61							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		AGCTGTCTTTGGTGAAATGCT	0.512000													65	133					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733542	50733542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50733542G>A	ENST00000300589.2	+	2	322	c.217G>A	c.(217-219)Ggc>Agc	p.G73S	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	73	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GGACTACGAGGGCTTCCACCT	0.637000													27	60					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215928826	215928826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215928826G>A	ENST00000272895.7	-	3	499	c.280C>T	c.(280-282)Cgt>Tgt	p.R94C		NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	94					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CCTTTCCTACGAAGCAGATCT	0.433000													45	139					0	0	1	0	0
CYP4V2	285440	broad.mit.edu	37	4	187130354	187130354	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187130354T>A	ENST00000378802.4	+	10	1637	c.1333T>A	c.(1333-1335)Ttc>Atc	p.F445I	CYP4V2_ENST00000502665.1_3'UTR	NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	445					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		TGAGCGGTTCTTCCCCGAGAA	0.527000													37	117					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6685009	6685009	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6685009C>T	ENST00000245907.6	-	30	4051	c.3959G>A	c.(3958-3960)cGa>cAa	p.R1320Q		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1320		Cleavage; by factor I.	R -> Q (in C3D; allotype C3'F02'; may inhibit IC3B synthesis).		complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCTTCTGATCGCAGGAGGCT	0.597000													12	41					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121414281	121414281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121414281C>T	ENST00000260197.7	+	13	1839	c.1710C>T	c.(1708-1710)acC>acT	p.T570T	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	570					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AAGGGGAGACCTGGAAAACAT	0.458000													26	111					0	0	1	0	0
UNCX	340260	broad.mit.edu	37	7	1275593	1275593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:1275593C>T	ENST00000316333.8	+	3	687	c.576C>T	c.(574-576)atC>atT	p.I192I		NM_001080461.1	NP_001073930.1	A6NJT0	UNC4_HUMAN	UNC homeobox	192					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|skin(1)|upper_aerodigestive_tract(1)	4		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		CGGAGGAGATCGCGCGCAAGG	0.652000													7	17					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102742443	102742443	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102742443C>T	ENST00000532855.1	-	0	602							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	ATGGAAGTCTCCATGAGCTTT	0.443000													5	14					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175372323	175372323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175372323C>T	ENST00000367674.1	-	4	1637	c.929G>A	c.(928-930)gGg>gAg	p.G310E	TNR_ENST00000263525.2_Missense_Mutation_p.G310E	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	310	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GACGCAGAGCCCCTCCTCACA	0.612000													15	58					0	0	1	0	0
TTLL13P	440307	broad.mit.edu	37	15	90793899	90793899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90793899G>A	ENST00000561573.1	+	2	301	c.37G>A	c.(37-39)Gaa>Aaa	p.E13K	TTLL13_ENST00000339615.5_Missense_Mutation_p.E13K|TTLL13_ENST00000438251.1_Missense_Mutation_p.E13K																							GGAATCAGAGGAAGACTATGT	0.473000													32	48					0	0	1	0	0
CLDN1	9076	broad.mit.edu	37	3	190039867	190039867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:190039867G>A	ENST00000295522.3	-	1	397	c.129C>T	c.(127-129)gcC>gcT	p.A43A		NM_021101.4	NP_066924.1	O95832	CLD1_HUMAN	claudin 1	43					calcium-independent cell-cell adhesion|interspecies interaction between organisms	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity			lung(9)	9	all_cancers(143;2.95e-10)|Ovarian(172;0.0512)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.015)		ACATGGCCTGGGCGGTCACGA	0.592000													25	91					0	0	1	0	0
DHH	50846	broad.mit.edu	37	12	49483723	49483723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49483723G>A	ENST00000266991.2	-	3	1416	c.1110C>T	c.(1108-1110)ctC>ctT	p.L370L		NM_021044.2	NP_066382.1	O43323	DHH_HUMAN	desert hedgehog	370					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						CCCCGCCGGGGAGCAGCGCCC	0.652000													3	6					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436710	56436710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:56436710C>T	ENST00000327381.5	+	3	1977	c.1877C>T	c.(1876-1878)tCc>tTc	p.S626F		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	626						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TTTGAATGTTCCCCATCTCCT	0.453000													24	55					0	0	1	0	0
OFCC1	266553	broad.mit.edu	37	6	9933535	9933535	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:9933535G>A	ENST00000316020.6	-	3	222	c.223C>T	c.(223-225)Cag>Tag	p.Q75*	OFCC1_ENST00000472329.1_5'UTR					orofacial cleft 1 candidate 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)	11	Ovarian(93;0.0473)|Breast(50;0.201)	all_hematologic(90;0.124)				GCCTTCTGCTGAAACTTCTGG	0.363000													17	66					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57963926	57963926	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57963926A>T	ENST00000455537.2	+	12	1548	c.1274A>T	c.(1273-1275)tAt>tTt	p.Y425F	KIF5A_ENST00000286452.5_Missense_Mutation_p.Y336F	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	425					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CGCCGTCTCTATAAGCAGCTT	0.572000													7	16					0	0	1	0	0
U66061.31	0	broad.mit.edu	37	7	142423749	142423749	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142423749G>A	ENST00000506718.1	+	0	757																											CAAGAACAAGGAGACTCCTCC	0.547000													8	20					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18788653	18788653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18788653G>A	ENST00000406451.3	+	14	2076	c.1926G>A	c.(1924-1926)ctG>ctA	p.L642L	HDAC9_ENST00000401921.1_Silent_p.L601L|HDAC9_ENST00000441542.2_Silent_p.L645L|HDAC9_ENST00000432645.2_Silent_p.L642L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	642	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CCTTGATGCTGAAACACCAGT	0.438000													11	22					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142658103	142658103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142658103G>A	ENST00000355265.2	-	4	786	c.312C>T	c.(310-312)ttC>ttT	p.F104F	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	104					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AGGCAAAGCTGAAGAAGTCGG	0.512000													35	136					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982196	7982196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7982196C>T	ENST00000328600.2	-	2	1124	c.963G>A	c.(961-963)gcG>gcA	p.A321A		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	321	NACHT.						ATP binding	p.A321A(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGAAGTACCTCGCCCTCTCCT	0.512000													40	93					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141600150	141600150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141600150C>T	ENST00000442267.2	-	5	871	c.797G>A	c.(796-798)cGa>cAa	p.R266Q		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	266						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				GGGCAGGGATCGATCTTGTTC	0.418000													71	150					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21899156	21899156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21899156G>A	ENST00000399982.2	-	1	711	c.647C>T	c.(646-648)tCc>tTc	p.S216F	CHD8_ENST00000557364.1_Missense_Mutation_p.S216F|CHD8_ENST00000430710.3_Intron|CHD8_ENST00000555962.1_Intron	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	216					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGAGACAATGGAAACACCTGG	0.567000													7	32					0	0	1	0	0
GLS	2744	broad.mit.edu	37	2	191795172	191795172	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:191795172C>T	ENST00000320717.3	+	13	1693	c.1435C>T	c.(1435-1437)Cct>Tct	p.P479S	GLS_ENST00000338435.4_Missense_Mutation_p.P479S|GLS_ENST00000409215.1_5'UTR|GLS_ENST00000409428.1_5'UTR|GLS_ENST00000409626.1_Missense_Mutation_p.P50S	NM_014905.4	NP_055720.3	O94925	GLSK_HUMAN	glutaminase	479					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGTTGGTCTTCCTGCAAAATC	0.408000													15	67					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238277484	238277484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238277484G>A	ENST00000295550.4	-	10	5074	c.4622C>T	c.(4621-4623)cCc>cTc	p.P1541L	COL6A3_ENST00000353578.4_Missense_Mutation_p.P1335L|COL6A3_ENST00000409809.1_Missense_Mutation_p.P1335L|COL6A3_ENST00000472056.1_Missense_Mutation_p.P934L|COL6A3_ENST00000346358.4_Missense_Mutation_p.P1341L|COL6A3_ENST00000347401.3_Missense_Mutation_p.P1340L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1541	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CAGGTGTTGGGGCACCCCGTC	0.572000													38	88					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120809324	120809324	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:120809324G>A	ENST00000369144.3	-	17	2774	c.2647C>T	c.(2647-2649)Ctt>Ttt	p.L883F	EIF3A_ENST00000541549.1_Missense_Mutation_p.L849F|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	883					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TTTCTAGAAAGGGAACTATCG	0.403000													72	183					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202291	56202291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56202291C>T	ENST00000361673.3	-	5	5341	c.5128G>A	c.(5128-5130)Gag>Aag	p.E1710K		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1710							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTCTTGACCTCCTCTGACCCC	0.567000													38	117					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059369	248059369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248059369C>T	ENST00000537741.1	+	3	738	c.481C>T	c.(481-483)Cct>Tct	p.P161S	OR2W3_ENST00000360358.3_Missense_Mutation_p.P161S			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCCATGTCTCCTGTGACCCT	0.647000													29	65					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003483	122003483	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122003483C>T	ENST00000498619.1	+	7	3150	c.2712C>T	c.(2710-2712)gtC>gtT	p.V904V	CASR_ENST00000296154.5_Silent_p.V894V|CASR_ENST00000490131.1_Silent_p.V894V	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	894					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCAGCAACGTCTCCCGCAAGC	0.652000													21	33					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88482261	88482261	+	Silent	SNP	C	C	T	rs148640386		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:88482261C>T	ENST00000324166.5	+	5	2537	c.846C>T	c.(844-846)gtC>gtT	p.V282V	THNSL2_ENST00000343544.4_Silent_p.V282V|THNSL2_ENST00000358591.2_Silent_p.V282V|THNSL2_ENST00000377254.3_Silent_p.V282V|THNSL2_ENST00000449349.1_Intron|THNSL2_ENST00000496844.1_3'UTR|THNSL2_ENST00000402102.1_Silent_p.V282V	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	282					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						TCCGTCTGGTCGTGGCAGTGA	0.463000													15	63					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35247748	35247748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:35247748G>A	ENST00000381318.3	+	34	4552	c.4264G>A	c.(4264-4266)Gaa>Aaa	p.E1422K	AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000437442.2_Intron|ITSN1_ENST00000399367.3_Missense_Mutation_p.E1417K|ITSN1_ENST00000399326.3_3'UTR|ITSN1_ENST00000381285.4_Missense_Mutation_p.E1422K	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	1422	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						CCAGGTGAACGAAGGGGTGCG	0.607000													37	93					0	0	1	0	0
SLC24A4	123041	broad.mit.edu	37	14	92905734	92905734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92905734C>T	ENST00000532405.1	+	4	600	c.374C>T	c.(373-375)tCt>tTt	p.S125F	SLC24A4_ENST00000531433.1_Missense_Mutation_p.S125F|SLC24A4_ENST00000298877.1_Missense_Mutation_p.S108F|SLC24A4_ENST00000393265.2_Missense_Mutation_p.S61F|SLC24A4_ENST00000351924.5_Missense_Mutation_p.S108F			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	125						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		TTTGTTCCGTCTCTAGAGAAG	0.527000													31	133					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150828306	150828306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150828306C>T	ENST00000370357.4	+	10	1084	c.839C>T	c.(838-840)cCa>cTa	p.P280L		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	280						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGAATCTCCAGGTAGGTAC	0.373000													31	44					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278658	36278658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36278658C>T	ENST00000007510.4	+	21	3335	c.3191C>T	c.(3190-3192)tCc>tTc	p.S1064F	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.S900F|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.S903F			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1064					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CAGCCCAGTTCCCCAGCCCCA	0.667000													10	84					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75248676	75248676	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75248676C>T	ENST00000325680.7	+	4	2054	c.1930C>T	c.(1930-1932)Cct>Tct	p.P644S	YLPM1_ENST00000238571.3_Missense_Mutation_p.P449S|YLPM1_ENST00000552421.1_Missense_Mutation_p.P644S	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	449					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGGGATACCTCCTCAGTTAAC	0.547000													23	55					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52571623	52571623	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52571623G>T	ENST00000591504.1	-	12	1248	c.974C>A	c.(973-975)tCc>tAc	p.S325Y	CCDC68_ENST00000337363.4_Missense_Mutation_p.S325Y|CCDC68_ENST00000432185.1_Missense_Mutation_p.S325Y	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	325										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TAAATAAGGGGAAACACCTTC	0.378000													15	58					1.02788e-11	1.03227e-11	1	1	0
SLC39A1	27173	broad.mit.edu	37	1	153932928	153932928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153932928G>A	ENST00000368623.3	-	3	1380	c.621C>T	c.(619-621)gcC>gcT	p.A207A	SLC39A1_ENST00000310483.6_Silent_p.A207A|SLC39A1_ENST00000537590.1_Silent_p.A105A|SLC39A1_ENST00000356205.4_Silent_p.A207A|SLC39A1_ENST00000368621.1_Silent_p.A207A			Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter), member 1	207						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		ACAGCTCCATGGCCCGAGCCC	0.667000													16	35					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76812818	76812818	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76812818G>A	ENST00000286719.7	-	4	580	c.224C>T	c.(223-225)cCc>cTc	p.P75L		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	75					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GTGGCTGCTGGGGATGAAGTG	0.517000													85	221					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16008341	16008341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16008341G>A	ENST00000221700.5	-	2	176	c.81C>T	c.(79-81)gcC>gcT	p.A27A	CYP4F2_ENST00000592328.1_Silent_p.A27A|CYP4F2_ENST00000011989.7_5'UTR	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	27					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GGAGCCAGGAGGCCCCGACCA	0.647000													21	80					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84811201	84811201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:84811201C>T	ENST00000389394.3	+	15	2445	c.2308C>T	c.(2308-2310)Cct>Tct	p.P770S	DNAH6_ENST00000237449.6_Missense_Mutation_p.P770S|DNAH6_ENST00000398278.2_Missense_Mutation_p.P770S	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	770	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						GCCCACACCTCCTGAAGACTT	0.398000													36	133					0	0	1	0	0
TTC39A	22996	broad.mit.edu	37	1	51771684	51771684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:51771684C>T	ENST00000262676.5	-	7	809	c.649G>A	c.(649-651)Gga>Aga	p.G217R	TTC39A_ENST00000451380.1_Missense_Mutation_p.G185R|TTC39A_ENST00000447632.2_Missense_Mutation_p.G221R|TTC39A_ENST00000371750.5_Missense_Mutation_p.G186R|TTC39A_ENST00000371747.3_Missense_Mutation_p.G220R|TTC39A_ENST00000262675.7_Missense_Mutation_p.G158R|TTC39A_ENST00000413473.2_Missense_Mutation_p.G189R			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	221							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						TTCACTCCTCCTTCAAAGTGC	0.562000													34	78					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109766349	109766349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:109766349G>A	ENST00000399132.1	-	29	2104	c.1574C>T	c.(1573-1575)cCt>cTt	p.P525L	COL25A1_ENST00000399126.1_Missense_Mutation_p.P525L|COL25A1_ENST00000399127.1_Missense_Mutation_p.P498L	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	525						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		ACTTACAGAAGGACCCTGTGG	0.453000													70	184					0	0	1	0	0
FAM198B	51313	broad.mit.edu	37	4	159092037	159092037	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:159092037G>C	ENST00000296530.8	-	2	1112	c.491C>G	c.(490-492)cCt>cGt	p.P164R	FAM198B_ENST00000585682.1_Missense_Mutation_p.P164R|FAM198B_ENST00000393807.5_Missense_Mutation_p.P164R|RP11-597D13.9_ENST00000503611.1_RNA|FAM198B_ENST00000589306.1_Intron|FAM198B_ENST00000592057.1_Missense_Mutation_p.P164R	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	164						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						AGCGTACCCAGGTGCTACAGC	0.632000											OREG0016378	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	56					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58209029	58209029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58209029G>A	ENST00000377918.3	+	1	2375	c.2349G>A	c.(2347-2349)atG>atA	p.M783I		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	783					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGAACGTCATGAACGTGGTGA	0.587000													5	32					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55136211	55136211	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55136211C>T	ENST00000314706.3	+	1	852	c.852C>T	c.(850-852)ttC>ttT	p.F284F		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						CCTGTATCTTCTTGTATGCAA	0.408000													79	257					0	0	1	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993752	45993752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45993752C>T	ENST00000400374.3	+	1	147	c.117C>T	c.(115-117)ccC>ccT	p.P39P	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	39	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						GCTGCGAGCCCCCCTGCTGCG	0.701000													7	66					0	0	1	0	0
SLC45A2	51151	broad.mit.edu	37	5	33964098	33964098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33964098G>A	ENST00000382102.3	-	3	643	c.586C>T	c.(586-588)Ctt>Ttt	p.L196F	SLC45A2_ENST00000296589.4_Missense_Mutation_p.L196F|SLC45A2_ENST00000342059.3_Missense_Mutation_p.L137F|SLC45A2_ENST00000345083.5_Intron|SLC45A2_ENST00000509381.1_Intron	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	196					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						GCACCCAAAAGGTAACCCAGG	0.458000													8	28					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	124979297	124979297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:124979297C>T	ENST00000431078.1	+	2	462	c.98C>T	c.(97-99)cCa>cTa	p.P33L		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	33	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGTGATGATCCACTAGCATCC	0.448000													4	14					0	0	1	0	0
RPL12P38	645688	broad.mit.edu	37	17	58512655	58512655	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58512655C>T	ENST00000588627.1	-	0	702																											ACCTTCTCTCCCTTCTTTGCA	0.498000													14	43					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12192799	12192799	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12192799G>A	ENST00000432424.2	+	0	919							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TCATTGAACAGACATACTACC	0.438000													7	29					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333020	70333020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70333020G>A	ENST00000338508.4	-	32	3380	c.3381C>T	c.(3379-3381)ttC>ttT	p.F1127F	SHANK2_ENST00000423696.2_Silent_p.F747F|SHANK2_ENST00000409161.1_Silent_p.F530F|SHANK2_ENST00000449833.2_Silent_p.F531F			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	747					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCTCCTCGGGGAACATGGAGG	0.667000													14	45					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976675	38976675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38976675G>A	ENST00000355481.4	+	34	5511	c.5380G>A	c.(5380-5382)Gcc>Acc	p.A1794T	RYR1_ENST00000359596.3_Missense_Mutation_p.A1794T|RYR1_ENST00000360985.3_Missense_Mutation_p.A1794T	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1794	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCAGCAGAGGCCCCGGCCCG	0.716000													17	40					0	0	1	0	0
HTR1E	3354	broad.mit.edu	37	6	87725215	87725215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:87725215C>T	ENST00000305344.4	+	2	866	c.163C>T	c.(163-165)Cag>Tag	p.Q55*	HTR1E_ENST00000369584.1_Nonsense_Mutation_p.Q55*	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	55					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GAAGCTCCACCAGCCTGCCAA	0.542000													25	44					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4277346	4277346	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4277346C>T	ENST00000404826.2	+	42	6199	c.6060C>T	c.(6058-6060)atC>atT	p.I2020I	SDK1_ENST00000389531.3_Silent_p.I2000I|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2020					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCAGCCTGATCGTCATCCTGC	0.567000													27	85					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258375	56258375	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56258375C>T	ENST00000327216.2	-	1	496	c.472G>A	c.(472-474)Gag>Aag	p.E158K		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					CACATGGTCTCCATCAGGCCA	0.512000													36	94					0	0	1	0	0
ESYT2	57488	broad.mit.edu	37	7	158528282	158528282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:158528282G>A	ENST00000251527.5	-	20	2563	c.2498C>T	c.(2497-2499)tCg>tTg	p.S833L	ESYT2_ENST00000435514.2_Missense_Mutation_p.S268L	NM_020728.2	NP_065779.1	A0FGR8	ESYT2_HUMAN	extended synaptotagmin-like protein 2	861	C2 3.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(16)|prostate(2)	32						TTCTGGTAACGAAACACTGAA	0.438000													56	124					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71491387	71491387	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71491387C>T	ENST00000296755.7	+	5	2503	c.2205C>T	c.(2203-2205)ctC>ctT	p.L735L		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	735	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTAAGAAGCTCCCTAAAGACG	0.388000													37	65					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88307707	88307707	+	Silent	SNP	G	G	A	rs142829279		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:88307707G>A	ENST00000357081.3	-	3	198	c.54C>T	c.(52-54)atC>atT	p.I18I	AGTPBP1_ENST00000376081.4_Silent_p.I18I|AGTPBP1_ENST00000491784.1_5'UTR|AGTPBP1_ENST00000337006.4_5'UTR|AGTPBP1_ENST00000376083.3_Silent_p.I18I|AGTPBP1_ENST00000376109.3_Silent_p.I70I			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	18					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						GGAGTCCTACGATCCTAGAAT	0.383000													16	63					0	0	1	0	0
DAZL	1618	broad.mit.edu	37	3	16636058	16636058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:16636058C>T	ENST00000250863.8	-	8	950	c.663G>A	c.(661-663)agG>agA	p.R221R	DAZL_ENST00000399444.2_Silent_p.R201R	NM_001190811.1	NP_001177740.1	Q92904	DAZL_HUMAN	deleted in azoospermia-like	201					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity		RAF1/DAZL(2)	endometrium(1)|large_intestine(3)|lung(4)|prostate(3)	11						CAACATAGCTCCTTTGCTCCC	0.308000													18	31					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8615558	8615558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8615558C>T	ENST00000338257.8	-	9	1059	c.792G>A	c.(790-792)ggG>ggA	p.G264G		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	264	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						TGGGCGGGATCCCAATAACCT	0.602000													24	77					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38990420	38990420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:38990420G>A	ENST00000318792.1	+	2	224	c.214G>A	c.(214-216)Gat>Aat	p.D72N		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	72										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		tctgggAGAAGATGCTTCCCT	0.498000													21	42					0	0	1	0	0
C12orf54	121273	broad.mit.edu	37	12	48884612	48884612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48884612G>A	ENST00000314014.2	+	6	317	c.186G>A	c.(184-186)cgG>cgA	p.R62R	C12orf54_ENST00000548364.1_Silent_p.R62R|RP11-722P11.4_ENST00000551847.1_RNA	NM_152319.3	NP_689532.1	Q6X4T0	CL054_HUMAN	chromosome 12 open reading frame 54	62										endometrium(1)|large_intestine(4)	5						AAGATGCTCGGATTCGAGGTA	0.433000													51	105					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024324	76024324	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76024324C>T	ENST00000393004.2	-	5	1445	c.1224G>A	c.(1222-1224)agG>agA	p.R408R	FILIP1_ENST00000237172.7_Silent_p.R408R|FILIP1_ENST00000370020.1_Silent_p.R309R|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	408										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GCAGCTTCTTCCTCAATTCCC	0.428000													14	152					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60549101	60549101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:60549101C>T	ENST00000373886.3	+	7	684	c.680C>T	c.(679-681)tCt>tTt	p.S227F		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	227					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						AATTCCCCCTCTATTCAGCAT	0.403000													44	98					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24578598	24578598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24578598C>T	ENST00000319715.4	+	15	2156	c.1724C>T	c.(1723-1725)cCt>cTt	p.P575L	RBBP6_ENST00000348022.2_Missense_Mutation_p.P575L|RBBP6_ENST00000381039.3_Intron	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	575					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		cttcctctccctccgggtgtt	0.577000													45	179					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424120	56424120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56424120G>A	ENST00000588751.1	-	5	1087	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S	NLRP13_ENST00000342929.3_Missense_Mutation_p.P355S			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	355	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTAGCCAGGGGAACCAATTCT	0.473000													35	84					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209165796	209165796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:209165796C>T	ENST00000264380.4	+	9	1344	c.1186C>T	c.(1186-1188)Cga>Tga	p.R396*	PIKFYVE_ENST00000308862.6_Nonsense_Mutation_p.R310*|PIKFYVE_ENST00000392202.3_Nonsense_Mutation_p.R299*|PIKFYVE_ENST00000407449.1_Nonsense_Mutation_p.R396*	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	396	DEP.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding	p.R396*(1)		NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						CTGGCTAATCCGAAATGGGCA	0.388000													15	63					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059716	152059716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152059716C>T	ENST00000368806.1	-	3	506	c.442G>A	c.(442-444)Gaa>Aaa	p.E148K		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	148							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GCTCCACTTTCTTCAGGGATG	0.468000													36	84					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205133001	205133001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205133001G>A	ENST00000367162.3	-	4	1437	c.1407C>T	c.(1405-1407)atC>atT	p.I469I	DSTYK_ENST00000367161.3_Silent_p.I469I|DSTYK_ENST00000367160.4_Intron	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	469						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						TAAGTCGGGAGATGATGAGTT	0.507000													15	107					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32500794	32500794	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32500794C>T	ENST00000266088.4	+	14	1937	c.1687C>T	c.(1687-1689)Ctg>Ttg	p.L563L	SLC5A1_ENST00000543737.1_Silent_p.L436L	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	563					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						GTGTTGGAGCCTGCGCAACAG	0.498000													11	57					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306249	2306249	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:2306249G>A	ENST00000290974.2	-	8	2157	c.1818C>T	c.(1816-1818)gcC>gcT	p.A606A	ZFYVE28_ENST00000515312.1_Silent_p.A536A|ZFYVE28_ENST00000511071.1_Silent_p.A576A|RP11-478C1.7_ENST00000510632.1_RNA	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	606					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GTCTCTCAGGGGCCCTGTCGC	0.677000													8	43					0	0	1	0	0
LILRB3	11025	broad.mit.edu	37	19	54722248	54722248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54722248C>T	ENST00000391750.1	-	12	1711	c.1575G>A	c.(1573-1575)agG>agA	p.R525R	LILRA6_ENST00000270464.5_Silent_p.R525R|LILRB3_ENST00000245620.9_Silent_p.R525R|LILRB3_ENST00000424807.1_Silent_p.R525R|LILRA6_ENST00000419410.2_Silent_p.R525R|LILRA6_ENST00000440558.2_Silent_p.R525R|LILRB3_ENST00000346401.6_Silent_p.R537R|LILRB3_ENST00000469273.1_5'UTR|LILRB3_ENST00000407860.2_Silent_p.R542R|LILRA6_ENST00000391735.3_Intron			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	525				R -> G (in Ref. 2; AAB87667).	cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCAGCTCCACCCTGTCCTCAG	0.617000													18	76					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124369665	124369665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124369665G>A	ENST00000360013.3	+	38	5799	c.5672G>A	c.(5671-5673)gGa>gAa	p.G1891E	KALRN_ENST00000459915.1_5'UTR|KALRN_ENST00000428018.2_Missense_Mutation_p.G162E|KALRN_ENST00000393496.1_Missense_Mutation_p.G232E|KALRN_ENST00000291478.4_Missense_Mutation_p.G194E	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1890					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGTCTAGAAGGAAGCTCATAC	0.498000													28	101					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615326	179615326	+	Missense_Mutation	SNP	G	G	A	rs142848087		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179615326G>A	ENST00000360870.5	-	46	12023	c.11801C>T	c.(11800-11802)tCt>tTt	p.S3934F	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9751							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCGAAAAGAATTTTCAAA	0.338000													12	27					0	0	1	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54107574	54107574	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54107574G>A	ENST00000548263.1	-	13	1750	c.1702C>T	c.(1702-1704)Cga>Tga	p.R568*	CALCOCO1_ENST00000262059.4_Nonsense_Mutation_p.R568*|CALCOCO1_ENST00000430117.2_Nonsense_Mutation_p.R483*|CALCOCO1_ENST00000550804.1_Nonsense_Mutation_p.R568*			Q9P1Z2	CACO1_HUMAN	calcium binding and coiled-coil domain 1	568	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	28						GAAGCCTCTCGAGGCCCAGCA	0.607000													10	119					0	0	1	0	0
RDH16	8608	broad.mit.edu	37	12	57345840	57345840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57345840G>A	ENST00000398138.3	-	4	1783	c.927C>T	c.(925-927)gtC>gtT	p.V309V	RDH16_ENST00000360752.4_5'UTR	NM_003708.3	NP_003699.3	O75452	RDH16_HUMAN	retinol dehydrogenase 16 (all-trans)	309					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)	16						GGCTTGGAGAGACCCAGTACA	0.547000													14	44					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79414146	79414146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79414146C>T	ENST00000307745.7	+	15	3248	c.3248C>T	c.(3247-3249)cCt>cTt	p.P1083L																								CTCGAGGACCCTGAAACTATG	0.662000													24	61					0	0	1	0	0
ABCE1	6059	broad.mit.edu	37	4	146029175	146029175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:146029175C>T	ENST00000296577.4	+	4	713	c.198C>T	c.(196-198)ccC>ccT	p.P66P	ABCE1_ENST00000502803.1_Intron	NM_001040876.1|NM_002940.2	NP_001035809.1|NP_002931.2	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E (OABP), member 1	66	4Fe-4S ferredoxin-type 2.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|lung(5)|prostate(2)|skin(3)	18	all_hematologic(180;0.151)					AGAAATGCCCCTTTGGCGCCT	0.294000													19	44					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842129	5842129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5842129G>A	ENST00000317037.2	+	1	586	c.564G>A	c.(562-564)aaG>aaA	p.K188K	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTGGCCAAGGTATCCTGTG	0.478000													50	209					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11725334	11725334	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11725334G>A	ENST00000262442.3	+	46	8873	c.8805G>A	c.(8803-8805)gaG>gaA	p.E2935E	DNAH9_ENST00000454412.2_Silent_p.E2935E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2935	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACAACAGAGAGAACTGTTGGA	0.478000													18	25					0	0	1	0	0
TRAV38-1	28644	broad.mit.edu	37	14	22740410	22740410	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22740410G>A	ENST00000390464.2	+	0	317																											TCACAGCTGGGGGACACTGCG	0.473000													17	47					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361307	107361307	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107361307G>A	ENST00000374779.2	-	1	481	c.388C>T	c.(388-390)Ctg>Ttg	p.L130L		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						GGATATCTCAGAGGGTTGCAG	0.512000													18	86					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67685211	67685211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67685211C>T	ENST00000334583.6	+	23	2634	c.2306C>T	c.(2305-2307)tCt>tTt	p.S769F	RLTPR_ENST00000545661.1_Missense_Mutation_p.S733F	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	769										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GCCAACTTCTCTCTCAGCGTG	0.612000													26	62					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178553105	178553105	+	Missense_Mutation	SNP	G	G	A	rs145330384		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178553105G>A	ENST00000251582.7	-	18	2745	c.2644C>T	c.(2644-2646)Cgc>Tgc	p.R882C		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	882	TSP type-1 2.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGCCTCCGGCGGCAGCCATAC	0.657000													39	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085995	9085995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9085995G>A	ENST00000397910.4	-	1	6023	c.5820C>T	c.(5818-5820)tcC>tcT	p.S1940S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1940	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCACTGGAATGGATGAAAAAG	0.488000													12	34					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20512748	20512748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20512748C>T	ENST00000504154.1	+	11	1298	c.1046C>T	c.(1045-1047)tCt>tTt	p.S349F	SLIT2_ENST00000273739.5_Missense_Mutation_p.S353F|SLIT2_ENST00000503823.1_Missense_Mutation_p.S349F|SLIT2_ENST00000503837.1_Missense_Mutation_p.S353F	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	349					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GGACTACGCTCTCTGAATTCA	0.383000													22	68					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135647	55135647	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55135647C>T	ENST00000314706.3	+	1	288	c.288C>T	c.(286-288)ttC>ttT	p.F96F		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						CTTTATCATTCATAGATACCG	0.433000													53	160					0	0	1	0	0
IGLV2-11	28816	broad.mit.edu	37	22	23135302	23135302	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23135302C>T	ENST00000390314.2	+	0	206																											AACTATGTCTCCTGGTACCAA	0.552000													168	397					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6520073	6520073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6520073G>A	ENST00000377828.1	+	13	2600	c.2432G>A	c.(2431-2433)cGa>cAa	p.R811Q	ESPN_ENST00000461727.1_Missense_Mutation_p.R245Q|ESPN_ENST00000416731.1_Missense_Mutation_p.R245Q|ESPN_ENST00000475228.1_3'UTR	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	811	Glu-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		GAGGAGGAGCGACAGAAGCAG	0.662000													8	29					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43441296	43441296	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43441296G>A	ENST00000446844.3	-	0	22				PSG7_ENST00000471557.1_RNA|PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				CCTGAGCACGGCTGTCAGCTG	0.617000													16	35					0	0	1	0	0
APP	351	broad.mit.edu	37	21	27284094	27284094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:27284094G>A	ENST00000358918.3	-	14	2067	c.1868C>T	c.(1867-1869)tCt>tTt	p.S623F	APP_ENST00000359726.3_Missense_Mutation_p.S567F|APP_ENST00000348990.5_Missense_Mutation_p.S548F|APP_ENST00000357903.3_Missense_Mutation_p.S604F|APP_ENST00000354192.3_Missense_Mutation_p.S492F|APP_ENST00000448388.2_Missense_Mutation_p.S513F|APP_ENST00000346798.3_Missense_Mutation_p.S623F|APP_ENST00000439274.2_Missense_Mutation_p.S567F|APP_ENST00000440126.3_Missense_Mutation_p.S599F	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	623					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				AGCCCCAAAAGAATGCCACGG	0.522000													6	45					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21840063	21840063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21840063G>A	ENST00000216297.2	-	3	638	c.300C>T	c.(298-300)gcC>gcT	p.A100A		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	100					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TGATGGCAGGGGCTCCATTAG	0.383000													16	59					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158368777	158368777	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158368777G>A	ENST00000334438.1	-	1	479	c.480C>T	c.(478-480)gcC>gcT	p.A160A		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TGAGGTTGGTGGCCACCAAAG	0.473000													41	94					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38646255	38646255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38646255G>A	ENST00000413689.1	-	11	1676	c.1483C>T	c.(1483-1485)Ccc>Tcc	p.P495S	SCN5A_ENST00000423572.2_Missense_Mutation_p.P495S|SCN5A_ENST00000425664.1_Missense_Mutation_p.P495S|SCN5A_ENST00000333535.4_Missense_Mutation_p.P495S|SCN5A_ENST00000451551.2_Missense_Mutation_p.P495S|SCN5A_ENST00000455624.2_Missense_Mutation_p.P495S|SCN5A_ENST00000449557.2_Missense_Mutation_p.P495S|SCN5A_ENST00000450102.2_Missense_Mutation_p.P495S|SCN5A_ENST00000443581.1_Missense_Mutation_p.P495S|SCN5A_ENST00000414099.2_Missense_Mutation_p.P495S	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	495					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCAGACTTGGGGAGCCTGTCC	0.527000													15	30					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38237609	38237609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38237609C>T	ENST00000379705.3	-	6	2489	c.1632G>A	c.(1630-1632)acG>acA	p.T544T	TRPC4_ENST00000338947.5_Silent_p.T371T|TRPC4_ENST00000358477.2_Silent_p.T544T|TRPC4_ENST00000379681.3_Silent_p.T544T|TRPC4_ENST00000447043.1_Silent_p.T544T|TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000379673.2_Silent_p.T544T|TRPC4_ENST00000494529.1_5'UTR|TRPC4_ENST00000379679.1_Silent_p.T371T|TRPC4_ENST00000355779.2_Silent_p.T544T			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	544					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTAACCCTTTCGTTTCTTCAT	0.348000													23	62					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723492	48723492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48723492G>A	ENST00000335017.1	+	1	730	c.418G>A	c.(418-420)Ggc>Agc	p.G140S		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	140	Arg-rich.				chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						GCAAGAGGAGGGCACGCGCGC	0.726000													5	16					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30724604	30724604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30724604C>T	ENST00000262518.4	+	15	2591	c.2206C>T	c.(2206-2208)Cgt>Tgt	p.R736C	SRCAP_ENST00000344771.4_Missense_Mutation_p.R736C|SRCAP_ENST00000395059.2_Missense_Mutation_p.R736C	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	736	Helicase ATP-binding.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCAGGCCTTCCGTCGCAAGAA	0.522000													25	82					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38954452	38954452	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38954452G>A	ENST00000355481.4	+	22	2879	c.2748G>A	c.(2746-2748)gaG>gaA	p.E916E	RYR1_ENST00000359596.3_Silent_p.E916E|RYR1_ENST00000360985.3_Silent_p.E916E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	916	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CAGAGCCTGAGAGGAACTACA	0.622000													38	95					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21165309	21165309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21165309G>A	ENST00000255882.6	-	9	1103	c.1017C>T	c.(1015-1017)atC>atT	p.I339I	PI4KA_ENST00000572273.1_Silent_p.I281I	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	281					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCTCCTCAACGATCTTCTTCA	0.458000													35	85					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74090859	74090859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74090859C>T	ENST00000443185.2	-	5	3527	c.3210G>A	c.(3208-3210)gcG>gcA	p.A1070A	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	1070					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGTAGAGGGTCGCAAAGTCCT	0.592000													18	67					0	0	1	0	0
ELK4	2005	broad.mit.edu	37	1	205589256	205589256	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205589256G>A	ENST00000357992.4	-	3	1257	c.918C>T	c.(916-918)gtC>gtT	p.V306V	ELK4_ENST00000289703.4_Silent_p.V306V	NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TTTCTAGCAAGACTGAATCCT	0.458000			T	SLC45A3	prostate								48	123					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5853187	5853187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:5853187G>A	ENST00000324989.7	-	5	918	c.830C>T	c.(829-831)tCc>tTc	p.S277F	CRMP1_ENST00000511535.1_5'UTR|CRMP1_ENST00000512574.1_Missense_Mutation_p.S161F|CRMP1_ENST00000397890.2_Missense_Mutation_p.S163F	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	163					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		GACTTGGAAGGAATTGACGCC	0.438000													61	156					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903019	5903019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5903019G>A	ENST00000378961.4	+	4	433	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	77						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						AACTGAAAATGAAAACACAAA	0.458000													29	68					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30632987	30632987	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30632987C>A	ENST00000376442.3	-	6	1181	c.986G>T	c.(985-987)tGg>tTg	p.W329L		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	329					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						CGCCTCCTCCCAGCGCCGCTG	0.617000													6	23					0.0215528	0.0215557	1	1	0
MYH14	79784	broad.mit.edu	37	19	50735323	50735323	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50735323C>T	ENST00000440075.2	+	10	1157	c.1110C>T	c.(1108-1110)atC>atT	p.I370I	MYH14_ENST00000425460.1_Silent_p.I370I|MYH14_ENST00000262269.8_Silent_p.I370I|MYH14_ENST00000376970.2_Silent_p.I362I|MYH14_ENST00000598205.1_Silent_p.I370I|MYH14_ENST00000596571.1_Silent_p.I362I|MYH14_ENST00000601313.1_Silent_p.I370I			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	362	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		ACGAGGAAATCATCTGTGAGT	0.627000													14	28					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76482830	76482830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:76482830C>T	ENST00000307431.8	+	7	1291	c.906C>T	c.(904-906)ctC>ctT	p.L302L	CNTNAP4_ENST00000478060.1_Silent_p.L278L|CNTNAP4_ENST00000377504.4_Silent_p.L302L|CNTNAP4_ENST00000476707.1_Silent_p.L306L|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	303	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AATTCAATCTCATGAATCTTG	0.388000													9	12					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47274755	47274755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47274755C>T	ENST00000396220.1	-	17	1915	c.1893G>A	c.(1891-1893)caG>caA	p.Q631Q	PREX1_ENST00000371941.3_Silent_p.Q631Q			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	631	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AGTCCTCCTCCTGGGGCAGGA	0.672000											OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	276					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147926752	147926752	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:147926752C>T	ENST00000361727.3	+	20	3778	c.3262C>T	c.(3262-3264)Cga>Tga	p.R1088*	CNTNAP2_ENST00000538075.1_Nonsense_Mutation_p.R147*	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1088	Laminin G-like 4.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.R1088*(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTTACAGATTCGATACAACCT	0.443000										HNSCC(39;0.1)			13	49					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139884519	139884519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139884519C>T	ENST00000297183.6	+	16	3242	c.3118C>T	c.(3118-3120)Cct>Tct	p.P1040S	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P1040S|ANKHD1_ENST00000360839.2_Missense_Mutation_p.P1040S	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGATGCCTCCTGTGTATCC	0.413000													36	97					0	0	1	0	0
FCN3	8547	broad.mit.edu	37	1	27697464	27697464	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27697464C>T	ENST00000270879.4	-	6	399		c.e6-1		FCN3_ENST00000354982.2_Splice_Site	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3						complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGAAACACCTGGGGGAGGG	0.577000													10	69					0	0	1	0	0
LIF	3976	broad.mit.edu	37	22	30639682	30639682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30639682C>T	ENST00000249075.3	-	3	722	c.567G>A	c.(565-567)ggG>ggA	p.G189G	LIF_ENST00000403987.3_3'UTR	NM_002309.4	NP_002300.1	P15018	LIF_HUMAN	leukemia inhibitory factor	189					immune response|leukemia inhibitory factor signaling pathway|negative regulation of hormone secretion|positive regulation of cell proliferation|positive regulation of macrophage differentiation|positive regulation of MAPKKK cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of metanephric nephron tubule epithelial cell differentiation		cytokine activity|growth factor activity|leukemia inhibitory factor receptor binding			breast(1)|lung(3)|skin(3)	7			Epithelial(10;0.171)			GCTTATACTTCCCCAGGAGTT	0.567000													47	105					0	0	1	0	0
OR51B2	79345	broad.mit.edu	37	11	5344754	5344754	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5344754G>A	ENST00000328813.2	-	1	828	c.774C>T	c.(772-774)ttC>ttT	p.F258F	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCTGTAAATGAATGTCAAAC	0.413000													19	90					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78458811	78458811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:78458811C>T	ENST00000566780.1	+	7	1016	c.650C>T	c.(649-651)cCc>cTc	p.P217L	WWOX_ENST00000402655.2_Intron|WWOX_ENST00000406884.2_Intron|WWOX_ENST00000408984.3_Missense_Mutation_p.P217L|WWOX_ENST00000539474.2_Intron	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	217	Interaction with MAPT (By similarity).|Mediates targeting to the mitochondria (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TTTGCTCTACCCTGGAGTCTC	0.468000													130	288					0	0	1	0	0
GBP6	163351	broad.mit.edu	37	1	89847259	89847259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89847259G>A	ENST00000370456.4	+	7	971	c.878G>A	c.(877-879)gGa>gAa	p.G293E	GBP6_ENST00000535065.1_Missense_Mutation_p.G163E	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	293							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		TTAGGTCTGGGAACTCTGGCA	0.483000													35	97					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22205510	22205510	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22205510G>A	ENST00000374695.3	-	18	2527	c.2448C>T	c.(2446-2448)tgC>tgT	p.C816C		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	816	Laminin EGF-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGATGTATGGGCAAGGGCAGG	0.647000													19	27					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47649221	47649221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47649221C>T	ENST00000398742.2	+	5	771	c.722C>T	c.(721-723)tCt>tTt	p.S241F	GPR111_ENST00000507065.1_Missense_Mutation_p.S241F|GPR111_ENST00000296862.1_Missense_Mutation_p.S309F			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	309					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TTCACTTTTTCTATGAGAATT	0.393000													9	155					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27938585	27938585	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:27938585G>A	ENST00000299340.4	-	2	519	c.176_splice	c.e2+1	p.S59_splice	CYYR1_ENST00000435845.2_Splice_Site_p.S167_splice|CYYR1_ENST00000400043.3_Splice_Site_p.S59_splice|AP001597.1_ENST00000357401.3_RNA	NM_052954.2	NP_443186.1	Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	59						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						GAATACTCACGAGAGGATATT	0.433000													10	32					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161747	57161747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57161747G>A	ENST00000371244.4	+	6	769	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	235	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TTATATCCCAGAATATCTCAA	0.418000													115	264					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385791	33385791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33385791C>T	ENST00000537089.1	-	6	641	c.323G>A	c.(322-324)gGa>gAa	p.G108E	AQP7_ENST00000377425.4_Missense_Mutation_p.G143E|AQP7_ENST00000541274.1_Silent_p.R68R|AQP7_ENST00000539936.1_Missense_Mutation_p.G200E			O14520	AQP7_HUMAN	aquaporin 7	200					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CGCCTCTGTTCCTGGCAGTGC	0.617000													13	74					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241710444	241710444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241710444G>A	ENST00000498729.2	-	15	1531	c.1285C>T	c.(1285-1287)Ctc>Ttc	p.L429F	KIF1A_ENST00000320389.7_Missense_Mutation_p.L420F	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	420					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CGCTCGTGGAGGCTGGACACG	0.642000													30	54					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30653799	30653799	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30653799G>A	ENST00000358107.4	-	2	382	c.383C>T	c.(382-384)tCc>tTc	p.S128F	MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	0					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						CACCTGAAGGGAGGGGTGCTC	0.647000													3	13					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220466101	220466101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220466101C>T	ENST00000456909.1	+	3	296	c.206C>T	c.(205-207)tCc>tTc	p.S69F	STK11IP_ENST00000295641.10_Missense_Mutation_p.S80F|STK11IP_ENST00000459692.1_3'UTR			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	80					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGCCGACTCCCCTGTTATT	0.567000													16	50					0	0	1	0	0
MTRF1	9617	broad.mit.edu	37	13	41826864	41826864	+	Missense_Mutation	SNP	C	C	T	rs146179881		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:41826864C>T	ENST00000379480.4	-	5	714	c.614G>A	c.(613-615)cGa>cAa	p.R205Q	MTRF1_ENST00000379477.1_Missense_Mutation_p.R205Q|MTRF1_ENST00000430347.2_Missense_Mutation_p.R218Q|MTRF1_ENST00000239852.6_5'UTR	NM_004294.2	NP_004285.2	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	205					regulation of translational termination	mitochondrion	translation release factor activity, codon specific	p.R205Q(1)		breast(1)|endometrium(4)|large_intestine(3)|lung(6)	14		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		AAATATTTCTCGGGTAAATTG	0.353000													14	46					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853634	42853634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:42853634C>T	ENST00000455697.1	-	8	2758	c.2473G>A	c.(2473-2475)Ggc>Agc	p.G825S	RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.G825S|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.G825S|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.G825S|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.G825S	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	825					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CAATTTTTGCCCTTGTGTCCC	0.403000													49	192					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139192924	139192924	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139192924G>A	ENST00000274710.3	+	3	607	c.402G>A	c.(400-402)cgG>cgA	p.R134R		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	134					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATGTGCGGGATGGCTTCA	0.617000													27	99					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26517322	26517322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26517322G>A	ENST00000456354.2	+	1	271	c.204G>A	c.(202-204)acG>acA	p.T68T		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	68					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAAATCACGAACAAAGCGG	0.602000													9	6					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197183905	197183905	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197183905G>A	ENST00000260983.2	-	9	1891	c.1709C>T	c.(1708-1710)tCt>tTt	p.S570F	HECW2_ENST00000409111.1_Missense_Mutation_p.S214F	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	570					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TACCTCTTGAGAGCCACACAG	0.607000													17	62					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19339336	19339336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19339336C>T	ENST00000252575.5	+	8	2950	c.2907C>T	c.(2905-2907)ttC>ttT	p.F969F	NCAN_ENST00000538881.1_Silent_p.F420F	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	969					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			TAGAGGACTTCGAACTGGAGG	0.642000													49	120					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185018440	185018440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:185018440C>T	ENST00000296741.2	-	7	1216	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	359					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		TCCATGAGCTCGTTGTCGTAG	0.567000													30	62					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854424	40854424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:40854424C>T	ENST00000254691.5	+	3	3189	c.2990C>T	c.(2989-2991)cCc>cTc	p.P997L	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	997	Pro-rich.				apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						CCAAGCCAGCCCTGGCCTCCC	0.527000													125	343					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179414114	179414114	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179414114G>A	ENST00000367618.3	+	16	1960	c.1573G>A	c.(1573-1575)Gag>Aag	p.E525K	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_Missense_Mutation_p.E525K	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	525										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GATCCTGAATGAGAAAAAAGA	0.383000													27	81					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635294	33635294	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33635294G>A	ENST00000380099.3	+	4	2086	c.2078G>A	c.(2077-2079)aGg>aAg	p.R693K	KL_ENST00000426690.2_3'UTR|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	693	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CCGTATACAAGGAATATGACA	0.493000													6	60					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32289578	32289578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32289578C>T	ENST00000400246.1	+	39	4186	c.4044C>T	c.(4042-4044)gtC>gtT	p.V1348V	DEPDC5_ENST00000382111.2_Silent_p.V1348V|DEPDC5_ENST00000400248.1_Silent_p.V1317V|DEPDC5_ENST00000400249.2_Silent_p.V1317V|DEPDC5_ENST00000382105.2_3'UTR|DEPDC5_ENST00000535622.1_Silent_p.V1248V|DEPDC5_ENST00000539165.1_Silent_p.V165V|DEPDC5_ENST00000266091.3_Silent_p.V1326V|DEPDC5_ENST00000382112.3_Silent_p.V1339V			O75140	DEPD5_HUMAN	DEP domain containing 5	1317					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CTGCCACTGTCCCAGAGCAGA	0.493000													26	55					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112525033	112525033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112525033G>A	ENST00000369697.1	-	1	385	c.316C>T	c.(316-318)Ccg>Tcg	p.P106S	KCND3_ENST00000315987.2_Missense_Mutation_p.P106S|KCND3_ENST00000302127.4_Missense_Mutation_p.P106S			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	106						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TCGTAGCGCGGGTAGTGCAGC	0.602000													31	63					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71850684	71850684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71850684C>T	ENST00000445078.2	+	5	738	c.667C>T	c.(667-669)Ccc>Tcc	p.P223S	FOLR3_ENST00000456237.1_Missense_Mutation_p.P225S|FOLR3_ENST00000442948.2_Missense_Mutation_p.P182S			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	181					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	GTCCTACTTCCCCACTCCAGC	0.592000													18	83					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8196821	8196821	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:8196821C>T	ENST00000402384.3	-	8	995	c.729G>A	c.(727-729)gaG>gaA	p.E243E	ICA1_ENST00000422063.2_Silent_p.E243E|ICA1_ENST00000396675.3_Silent_p.E243E|ICA1_ENST00000265577.7_Silent_p.E242E|ICA1_ENST00000401396.1_Silent_p.E231E|ICA1_ENST00000406470.2_Silent_p.E243E|ICA1_ENST00000407906.1_Silent_p.E243E			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	243	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		GAGAAGTTTTCTCCCAAAAAT	0.418000													29	65					0	0	1	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45671756	45671756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:45671756G>A	ENST00000359600.5	-	1	472	c.267C>T	c.(265-267)atC>atT	p.I89I	ZSWIM5_ENST00000464588.1_Intron	NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	89							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					CGGGCTCCGGGATCCGCTCGA	0.677000													12	27					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187209716	187209716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187209716C>T	ENST00000264692.4	+	15	2003	c.1670C>T	c.(1669-1671)aCc>aTc	p.T557I	F11_ENST00000403665.2_Missense_Mutation_p.T609I|RP11-215A19.1_ENST00000505103.1_RNA			P03951	FA11_HUMAN	coagulation factor XI	609	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GGTGTTTACACCAACGTGGTC	0.567000													11	72					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111772339	111772339	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111772339G>A	ENST00000261726.6	+	19	3175	c.3021G>A	c.(3019-3021)gaG>gaA	p.E1007E		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1007						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E1007D(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TGTCCCTGGAGAGCAGCAAGG	0.652000													16	41					0	0	1	0	0
CHTF18	63922	broad.mit.edu	37	16	839621	839621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:839621C>T	ENST00000317063.6	+	5	1103	c.1103C>T	c.(1102-1104)cCc>cTc	p.P368L	CHTF18_ENST00000455171.2_Missense_Mutation_p.P199L|CHTF18_ENST00000262315.9_Missense_Mutation_p.P171L|CHTF18_ENST00000491530.1_3'UTR			Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	171					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				CTGAGGCGGCCCCCCATCTTG	0.677000													22	54					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068338	5068338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5068338C>T	ENST00000380370.1	+	1	583	c.583C>T	c.(583-585)Cgt>Tgt	p.R195C		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGAAACATTCGTATCAATGG	0.438000													40	113					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142609852	142609852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142609852C>T	ENST00000265310.1	-	13	1932	c.1584G>A	c.(1582-1584)atG>atA	p.M528I		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	528					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					TGAACAGTGCCATGGGGTAGT	0.498000													37	83					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058581	9058581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9058581G>A	ENST00000397910.4	-	3	29068	c.28865C>T	c.(28864-28866)cCc>cTc	p.P9622L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9624	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGCTAGAGGGCATAACTTC	0.522000													20	53					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42379884	42379884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42379884G>A	ENST00000290472.3	-	2	154	c.60C>T	c.(58-60)acC>acT	p.T20T		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	20	C2.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		GCTGCCAGCAGGTAGAGGCCT	0.637000													12	40					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541273	55541273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55541273G>A	ENST00000361760.1	+	1	360	c.360G>A	c.(358-360)atG>atA	p.M120I		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TAGCAGCGATGGCTTATGACC	0.433000													69	192					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61468560	61468560	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61468560C>T	ENST00000343916.3	+	30	1732	c.1729C>T	c.(1729-1731)Cga>Tga	p.R577*	COL9A3_ENST00000462700.1_3'UTR	NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	577	Triple-helical region 2 (COL2).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					CCCTGGCGCTCGAGGACCCCC	0.672000													44	90					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86487924	86487924	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86487924G>A	ENST00000370571.2	-	18	2621	c.2256_splice	c.e18+1	p.S752_splice	COL24A1_ENST00000436319.1_Splice_Site_p.S752_splice	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	752	Collagen-like 4.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CAAACCTACTGAAGGCCCTGA	0.433000													25	56					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54914527	54914527	+	Missense_Mutation	SNP	C	C	T	rs141439711	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54914527C>T	ENST00000545554.1	+	30	6109	c.6109C>T	c.(6109-6111)Cgt>Tgt	p.R2037C	UNC13C_ENST00000537900.1_Missense_Mutation_p.R2035C|UNC13C_ENST00000260323.11_Missense_Mutation_p.R2037C|UNC13C_ENST00000539562.2_5'UTR			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2037					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATTTTCAGGTCGTTCCTCCAA	0.398000													28	61					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6924073	6924073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6924073G>A	ENST00000011653.4	+	5	780	c.522G>A	c.(520-522)ctG>ctA	p.L174L	CD4_ENST00000541982.1_Silent_p.L119L|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	174	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				TGTCTCAGCTGGAGCTCCAGG	0.547000													21	50					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180579	124180579	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124180579G>A	ENST00000357821.2	-	1	154	c.84C>T	c.(82-84)ttC>ttT	p.F28F		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GGAACAGGAGGAAGAGGGGCA	0.473000													30	125					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54759173	54759173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54759173C>T	ENST00000450632.1	-	5	978	c.901G>A	c.(901-903)Gac>Aac	p.D301N	LILRB5_ENST00000449561.2_Missense_Mutation_p.D310N|LILRB5_ENST00000316219.5_Missense_Mutation_p.D310N|LILRB5_ENST00000345866.6_Missense_Mutation_p.D210N			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	310	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCCAGGGGGTCGCTGGGGGCC	0.667000													22	42					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587930	55587930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55587930C>T	ENST00000333976.4	+	1	845	c.825C>T	c.(823-825)gcC>gcT	p.A275A		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TCAAAGTGGCCTCTGTGTTTT	0.498000													15	105					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42815746	42815746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42815746C>T	ENST00000398600.2	+	13	1986	c.961C>T	c.(961-963)Ccc>Tcc	p.P321S	MX1_ENST00000455164.2_Missense_Mutation_p.P321S|MX1_ENST00000288383.6_Missense_Mutation_p.P298S|MX1_ENST00000398598.3_Missense_Mutation_p.P321S	NM_001144925.1	NP_001138397.1	P20591	MX1_HUMAN	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	321					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GGCCACGGTTCCCTGCCTGGC	0.507000													40	135					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143993426	143993426	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143993426G>A	ENST00000323110.2	-	9	1484	c.1482C>T	c.(1480-1482)tcC>tcT	p.S494S		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	494					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TGAGGAGGGGGGACGTGCCAG	0.567000									Familial Hyperaldosteronism type I				24	57					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034580	52034580	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52034580C>T	ENST00000346477.3	-	2	329	c.261G>A	c.(259-261)gaG>gaA	p.E87E	SIGLEC6_ENST00000391797.3_Silent_p.E87E|SIGLEC6_ENST00000436458.1_Silent_p.E51E|SIGLEC6_ENST00000359982.4_Silent_p.E87E|SIGLEC6_ENST00000343300.4_Silent_p.E87E|SIGLEC6_ENST00000425629.3_Silent_p.E87E	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	87	Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CCCGGGTCTCCTCCTGCACTT	0.572000													36	100					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39504152	39504152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:39504152G>A	ENST00000518318.2	+	10	1877	c.1835G>A	c.(1834-1836)cGa>cAa	p.R612Q	POU6F2_ENST00000403058.1_Missense_Mutation_p.R648Q|POU6F2_ENST00000559001.1_Missense_Mutation_p.R593Q			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	648					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						AACTATGACCGAGAAGTAGTT	0.498000													4	21					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48753410	48753410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48753410C>T	ENST00000285238.8	+	22	3106	c.3026C>T	c.(3025-3027)tCc>tTc	p.S1009F	ABCC3_ENST00000510891.1_3'UTR	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1009	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AACAACACTTCCCTGAGGCTG	0.547000													21	34					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46806723	46806723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46806723C>T	ENST00000230588.4	+	14	2100	c.2091C>T	c.(2089-2091)atC>atT	p.I697I		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	697	EGF-like.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			TCAGGTGCATCTCTGGACATG	0.572000													58	139					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20150060	20150060	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20150060C>T	ENST00000245957.5	+	13	1417	c.1341C>T	c.(1339-1341)acC>acT	p.T447T	C20orf26_ENST00000377306.1_Silent_p.T447T|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000451767.2_Silent_p.T447T|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	447										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ACACCTGCACCCTCGAGCAGG	0.488000													27	81					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626504	49626504	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49626504G>A	ENST00000371571.4	-	2	657	c.372C>T	c.(370-372)ttC>ttT	p.F124F	RP5-955M13.4_ENST00000424566.1_RNA|KCNG1_ENST00000396017.3_Silent_p.F124F	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	124						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GGATAGTGCCGAAGGCCCCCG	0.632000													13	66					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133667776	133667776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133667776C>T	ENST00000310926.4	-	7	1174	c.901G>A	c.(901-903)Gag>Aag	p.E301K	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.E225K	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	301					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GACTTGGCCTCCTCCAACTTC	0.587000													32	78					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157803081	157803081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157803081G>A	ENST00000368174.4	-	5	1036	c.940C>T	c.(940-942)Cgt>Tgt	p.R314C		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	314	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCTGAGCAACGAACATTATCC	0.582000													38	78					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7510075	7510075	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7510075G>A	ENST00000313599.3	-	19	4344	c.4287C>T	c.(4285-4287)acC>acT	p.T1429T	CD163L1_ENST00000396630.1_Silent_p.T1397T|CD163L1_ENST00000416109.2_Silent_p.T1439T			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1429						extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CATGGTTGGGGGTGTCATCTG	0.463000													4	50					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017344	93017344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:93017344C>T	ENST00000521553.1	-	4	651	c.629G>A	c.(628-630)aGg>aAg	p.R210K	RUNX1T1_ENST00000520724.1_Splice_Site_p.R210_splice|RUNX1T1_ENST00000422361.2_Splice_Site_p.R210_splice|RUNX1T1_ENST00000436581.2_Splice_Site_p.R258_splice|RUNX1T1_ENST00000518844.1_Splice_Site_p.R220_splice|RUNX1T1_ENST00000360348.2_Splice_Site_p.R210_splice|RUNX1T1_ENST00000265814.3_Splice_Site_p.R247_splice|RUNX1T1_ENST00000396218.1_Splice_Site_p.R220_splice|RUNX1T1_ENST00000523629.1_Splice_Site_p.R247_splice			Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	247	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCCCTCTCACCTGTCTGGAGT	0.512000													21	100					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10885926	10885926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10885926G>A	ENST00000254488.2	+	5	717	c.651G>A	c.(649-651)ggG>ggA	p.G217G		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	217					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCTCTGACGGGATCGAGCACA	0.587000													19	41					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50169713	50169713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50169713G>A	ENST00000216267.8	-	10	3309	c.2823C>T	c.(2821-2823)ccC>ccT	p.P941P	BRD1_ENST00000404760.1_Silent_p.P1072P|BRD1_ENST00000342989.5_Silent_p.P667P|BRD1_ENST00000457780.2_3'UTR|BRD1_ENST00000542442.1_Silent_p.P629P|BRD1_ENST00000404034.1_Silent_p.P941P	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	941	PWWP.				histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CCGGGTAGGAGGGGTAGCCGC	0.692000													21	34					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50660972	50660972	+	Missense_Mutation	SNP	G	G	A	rs144692967	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50660972G>A	ENST00000439308.2	-	14	2812	c.2320C>T	c.(2320-2322)Cgg>Tgg	p.R774W	TUBGCP6_ENST00000248846.5_Missense_Mutation_p.R774W|TUBGCP6_ENST00000491449.1_5'UTR	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	774					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TTCTGCTCCCGACGAGCTGCC	0.567000													23	49					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559002	140559002	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140559002G>A	ENST00000239444.2	+	1	1632	c.1387G>A	c.(1387-1389)Gag>Aag	p.E463K		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		463	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGTCCGCGAGAACAACAG	0.627000													85	323					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89385059	89385059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89385059G>A	ENST00000439576.2	+	5	1092	c.718G>A	c.(718-720)Gag>Aag	p.E240K	ACAN_ENST00000558207.1_Missense_Mutation_p.E240K|ACAN_ENST00000352105.7_Missense_Mutation_p.E240K|ACAN_ENST00000559004.1_Missense_Mutation_p.E240K|ACAN_ENST00000561243.1_Missense_Mutation_p.E240K	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	240					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGACACCAACGAGACCTATGA	0.607000													31	109					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874255	74874255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74874255G>A	ENST00000331628.3	-	4	947	c.700C>T	c.(700-702)Cag>Tag	p.Q234*	SYNDIG1L_ENST00000554823.1_Nonsense_Mutation_p.Q234*	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	234					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						TGACCGTTCTGGGACATGTAA	0.642000													30	77					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669833	158669833	+	Missense_Mutation	SNP	G	G	A	rs150220329		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158669833G>A	ENST00000359610.2	-	1	653	c.610C>T	c.(610-612)Cat>Tat	p.H204Y		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					TCCACTGCATGAATGACATCC	0.488000													34	95					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82644788	82644788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:82644788G>A	ENST00000533655.1	+	6	2620	c.2408G>A	c.(2407-2409)gGt>gAt	p.G803D	C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000329143.3_Missense_Mutation_p.G502D|C11orf82_ENST00000430323.2_Missense_Mutation_p.G803D|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	803					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						GATCTTGATGGTAACTATGAA	0.368000													18	39					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54849677	54849677	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54849677C>T	ENST00000291759.4	-	3	401	c.345G>A	c.(343-345)ctG>ctA	p.L115L		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	115	Ig-like C2-type 1.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CTGTCACCACCAGCTCCAGGG	0.622000													16	67					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36129141	36129141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36129141C>T	ENST00000400445.3	+	44	7358	c.6824C>T	c.(6823-6825)aCt>aTt	p.T2275I	NBEA_ENST00000310336.4_Missense_Mutation_p.T2275I|NBEA_ENST00000537702.1_Missense_Mutation_p.T68I|NBEA_ENST00000540320.1_Missense_Mutation_p.T2275I|NBEA_ENST00000379939.2_Missense_Mutation_p.T2272I	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2275	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TCATTGGCCACTCCTCGACAG	0.328000													11	21					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106899194	106899194	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106899194C>T	ENST00000369701.3	+	8	1479	c.1252C>T	c.(1252-1254)Cga>Tga	p.R418*		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	418						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CGTGTCTTATCGAAGAGAGGC	0.502000													48	106					0	0	1	0	0
FAM169A	26049	broad.mit.edu	37	5	74100324	74100324	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:74100324C>T	ENST00000389156.4	-	8	996	c.906G>A	c.(904-906)caG>caA	p.Q302Q	FAM169A_ENST00000510496.1_Silent_p.Q242Q|FAM169A_ENST00000380515.3_3'UTR	NM_015566.2	NP_056381.1	Q9Y6X4	F169A_HUMAN	family with sequence similarity 169, member A	302										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	27						CTACAGTTAGCTGCATCTCAC	0.323000													28	79					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215866333	215866333	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215866333C>T	ENST00000272895.7	-	21	3031	c.2812G>A	c.(2812-2814)Gaa>Aaa	p.E938K	ABCA12_ENST00000389661.4_Missense_Mutation_p.E620K	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	938					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity	p.E938K(1)		NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTCTCCATTTCATCTATGGTT	0.388000													58	159					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61034973	61034973	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61034973G>A	ENST00000335613.5	-	16	2312	c.1926C>T	c.(1924-1926)ttC>ttT	p.F642F	VWCE_ENST00000535710.1_Silent_p.F107F	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	642	VWFC 5.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GCACAGACGGGAAGGTCTCGT	0.597000													21	76					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39885739	39885739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39885739C>T	ENST00000260356.5	+	19	3302	c.3137C>T	c.(3136-3138)tCc>tTc	p.S1046F		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	1046	TSP C-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GTCACCCAGTCCTACTGGGAC	0.547000													50	129					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348996	30348996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:30348996C>T	ENST00000327564.7	+	1	973	c.912C>T	c.(910-912)tcC>tcT	p.S304S	LRRC37B_ENST00000584368.1_Silent_p.S289S|LRRC37B_ENST00000543378.2_Silent_p.S195S|LRRC37B_ENST00000394713.3_Silent_p.S277S|LRRC37B_ENST00000341671.7_Silent_p.S277S			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	277						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				ACATCCAGTCCTCTTCACTCC	0.552000													91	85					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33342596	33342596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33342596G>A	ENST00000374796.2	-	9	4174	c.1604C>T	c.(1603-1605)tCg>tTg	p.S535L	NCOA6_ENST00000359003.2_Missense_Mutation_p.S535L			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	535	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						TGCTGTGGTCGAAGGCACCTG	0.498000													10	85					0	0	1	0	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044161	90044161	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90044161C>T	ENST00000462693.1	+	0	112																											GACCCAGACTCCACTCTCCTC	0.448000													40	103					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984557	85984557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85984557G>A	ENST00000372113.4	-	2	429	c.424C>T	c.(424-426)Ctc>Ttc	p.L142F	LRIT2_ENST00000538192.1_Missense_Mutation_p.L142F	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	142						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						AGCTCAGGGAGTGCATCAATC	0.527000													22	123					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40037088	40037088	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40037088G>A	ENST00000336649.4	+	8	957	c.957G>A	c.(955-957)tgG>tgA	p.W319*	CACNA1I_ENST00000407673.1_Nonsense_Mutation_p.W319*|CACNA1I_ENST00000404898.1_Nonsense_Mutation_p.W319*|CACNA1I_ENST00000402142.3_Nonsense_Mutation_p.W319*|CACNA1I_ENST00000401624.1_Nonsense_Mutation_p.W319*|CACNA1I_ENST00000400164.3_Nonsense_Mutation_p.W319*			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	319					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GTGTCAACTGGAACCGTTACT	0.587000													21	64					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158641160	158641160	+	Silent	SNP	G	G	A	rs41273525		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158641160G>A	ENST00000368148.3	-	12	1752	c.1572C>T	c.(1570-1572)gcC>gcT	p.A524A	SPTA1_ENST00000368147.3_Silent_p.A524A	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	524					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGGCAGTAAAGGCTTCCTCAA	0.468000													9	43					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444075	5444075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5444075C>T	ENST00000300778.4	+	1	735	c.645C>T	c.(643-645)ctC>ctT	p.L215L	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCCTCTGCTCATTGTGATCT	0.493000													46	151					0	0	1	0	0
FBXO9	26268	broad.mit.edu	37	6	52962573	52962573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52962573C>T	ENST00000244426.6	+	12	1461	c.1289C>T	c.(1288-1290)cCc>cTc	p.P430L	FBXO9_ENST00000323557.7_Missense_Mutation_p.P420L|FBXO9_ENST00000370939.3_Missense_Mutation_p.P386L	NM_012347.4	NP_036479.1	Q9UK97	FBX9_HUMAN	F-box protein 9	430						ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)|large_intestine(4)|lung(1)|pancreas(2)|skin(1)	9	Lung NSC(77;0.103)					ATGTACACCCCCTTGTTCTTC	0.403000													7	26					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14564752	14564752	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14564752G>A	ENST00000273083.3	-	0	556							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CCTCCCAAGAGATGGTGCAAG	0.483000													3	3					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13794146	13794146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13794146C>T	ENST00000265104.4	-	48	8013	c.7909G>A	c.(7909-7911)Gat>Aat	p.D2637N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2637	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATTCGTTTATCCACATAGCTC	0.358000									Kartagener syndrome				16	52					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102045066	102045066	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102045066A>C	ENST00000549145.1	+	15	1485	c.1385A>C	c.(1384-1386)gAa>gCa	p.E462A	MYBPC1_ENST00000360610.2_Missense_Mutation_p.E449A|MYBPC1_ENST00000541119.1_Missense_Mutation_p.E437A|MYBPC1_ENST00000536007.1_Missense_Mutation_p.E430A|MYBPC1_ENST00000553190.1_Missense_Mutation_p.E449A|MYBPC1_ENST00000547509.1_Missense_Mutation_p.E435A|MYBPC1_ENST00000547405.1_Missense_Mutation_p.E423A|RP11-755O11.2_ENST00000547027.1_RNA|MYBPC1_ENST00000545503.2_Missense_Mutation_p.E449A|MYBPC1_ENST00000441232.1_Missense_Mutation_p.E449A|MYBPC1_ENST00000392934.3_Missense_Mutation_p.E436A|MYBPC1_ENST00000361685.2_Missense_Mutation_p.E474A|MYBPC1_ENST00000361466.2_Missense_Mutation_p.E474A|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000551300.1_Missense_Mutation_p.E350A|MYBPC1_ENST00000550270.1_Missense_Mutation_p.E449A|MYBPC1_ENST00000452455.2_Missense_Mutation_p.E449A			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	449	Ig-like C2-type 4.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						CTTGGAAAAGAAATCTGCCTG	0.418000													36	121					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184792440	184792440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:184792440C>T	ENST00000367511.3	-	8	1039	c.846G>A	c.(844-846)ctG>ctA	p.L282L	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	282					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GATGCTGAACCAGGGTGTAGG	0.507000													19	51					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138738921	138738921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138738921G>A	ENST00000329447.5	-	1	847	c.583C>T	c.(583-585)Cca>Tca	p.P195S	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	195	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAGGGTTCTGGGATGGGGCCC	0.632000													16	49					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2967436	2967436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:2967436G>A	ENST00000397461.1	+	12	1715	c.1331G>A	c.(1330-1332)gGa>gAa	p.G444E	CNTN4_ENST00000397459.2_Missense_Mutation_p.G116E|CNTN4_ENST00000418658.1_Missense_Mutation_p.G444E|CNTN4_ENST00000427331.1_Missense_Mutation_p.G444E|CNTN4_ENST00000448906.2_Missense_Mutation_p.G116E|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000358480.3_Missense_Mutation_p.G225E	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	444	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TGGAAGAAAGGAAGGGATATA	0.338000													27	114					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50662634	50662634	+	Missense_Mutation	SNP	G	G	A	rs139968102		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50662634G>A	ENST00000439308.2	-	13	2698	c.2206C>T	c.(2206-2208)Cgt>Tgt	p.R736C	TUBGCP6_ENST00000248846.5_Missense_Mutation_p.R736C|TUBGCP6_ENST00000491449.1_5'UTR	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	736					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CGGAGTTCACGGGCGTAGCTG	0.617000													14	51					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52575039	52575039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52575039C>T	ENST00000591504.1	-	11	1202	c.928G>A	c.(928-930)Gta>Ata	p.V310I	CCDC68_ENST00000337363.4_Missense_Mutation_p.V310I|CCDC68_ENST00000432185.1_Missense_Mutation_p.V310I	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	310										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		GCCTTAGATACCTTTGTCCTA	0.378000													10	107					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47560241	47560241	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47560241G>A	ENST00000273859.3	+	12	2654	c.2385G>A	c.(2383-2385)acG>acA	p.T795T	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	795					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						TGGTGTATACGAAAGGCGCTG	0.418000													41	107					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113166771	113166771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113166771G>A	ENST00000401783.2	-	39	9838	c.9502C>T	c.(9502-9504)Cgc>Tgc	p.R3168C	SVEP1_ENST00000374469.1_Missense_Mutation_p.R3145C|SVEP1_ENST00000297826.5_Missense_Mutation_p.R1094C	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3168	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GGGAACCAGCGACCATCTTTC	0.413000													111	203					0	0	1	0	0
NCR1	9437	broad.mit.edu	37	19	55417934	55417934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55417934G>A	ENST00000594765.1	+	3	149	c.124G>A	c.(124-126)Gaa>Aaa	p.E42K	NCR1_ENST00000447255.1_Missense_Mutation_p.E42K|NCR1_ENST00000598576.1_Missense_Mutation_p.E30K|NCR1_ENST00000291890.4_Missense_Mutation_p.E42K|NCR1_ENST00000350790.5_Intron|NCR1_ENST00000338835.5_Missense_Mutation_p.E42K|NCR1_ENST00000357397.5_Intron			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	42	Ig-like 1.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		GGTTCCAAAGGAAAAGCAAGT	0.547000													44	91					0	0	1	0	0
FGF9	2254	broad.mit.edu	37	13	22275367	22275367	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:22275367C>T	ENST00000382353.5	+	3	950	c.420C>T	c.(418-420)ttC>ttT	p.F140F	FGF9_ENST00000478546.1_3'UTR	NM_002010.2	NP_002001.1	P31371	FGF9_HUMAN	fibroblast growth factor 9	140					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|male gonad development|positive regulation of cell division	extracellular space	growth factor activity|heparin binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|skin(2)	9		all_cancers(29;1.23e-20)|all_epithelial(30;9.83e-19)|all_lung(29;9.64e-17)|Lung SC(185;0.0262)|Breast(139;0.106)		all cancers(112;3.92e-05)|Epithelial(112;0.000166)|OV - Ovarian serous cystadenocarcinoma(117;0.00314)|Lung(94;0.163)		GAGAACAGTTCGAAGAAAACT	0.393000													17	41					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2172905	2172905	+	Missense_Mutation	SNP	G	G	A	rs140423155		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:2172905G>A	ENST00000511885.2	-	12	1731	c.1378C>T	c.(1378-1380)Cgt>Tgt	p.R460C	POLN_ENST00000382865.1_Missense_Mutation_p.R460C|POLN_ENST00000515357.1_5'UTR			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	460					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TCCTTGAGACGAGCCTGAAAA	0.363000								DNA polymerases (catalytic subunits)					29	62					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848305	215848305	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215848305G>A	ENST00000366943.2	-	63	13334	c.12948C>T	c.(12946-12948)ttC>ttT	p.F4316F	USH2A_ENST00000307340.3_Silent_p.F4316F			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4316	Fibronectin type-III 28.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAGTGTAATTGAAAGTCACAG	0.448000										HNSCC(13;0.011)			59	125					0	0	1	0	0
FCN1	2219	broad.mit.edu	37	9	137809704	137809704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137809704C>T	ENST00000371806.3	-	1	105	c.14G>A	c.(13-15)gGa>gAa	p.G5E		NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1	5					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CATGGTGGCTCCACTCAGCTC	0.582000													21	62					0	0	1	0	0
TRBV19	28568	broad.mit.edu	37	7	142326973	142326973	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142326973G>A	ENST00000390393.3	+	0	479																											GGAGAAGAAGGAATCCTTTCC	0.488000													32	142					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14960278	14960278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14960278G>A	ENST00000285046.5	+	13	3617	c.3507G>A	c.(3505-3507)atG>atA	p.M1169I	FGD5_ENST00000476851.1_3'UTR|FGD5_ENST00000543601.1_Missense_Mutation_p.M928I	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1169	PH 1.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GCCCTGTGATGGAGAAAGTGC	0.597000													20	54					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67912442	67912442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67912442C>T	ENST00000358933.5	+	10	1331	c.1092C>T	c.(1090-1092)gtC>gtT	p.V364V	EDC4_ENST00000574770.1_3'UTR	NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	364					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTTGCAGTGTCCCTTTCTGGA	0.567000													34	83					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2426252	2426252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2426252C>T	ENST00000452833.1	-	24	3427	c.3419G>A	c.(3418-3420)gGa>gAa	p.G1140E	TRPM5_ENST00000155858.6_Missense_Mutation_p.G1138E|TRPM5_ENST00000533060.1_Missense_Mutation_p.G1146E|TRPM5_ENST00000528453.1_Missense_Mutation_p.G1139E|AC124057.5_ENST00000433035.1_RNA			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	1138						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CAGCTGGCTTCCCTCGCCACA	0.662000													17	26					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76464930	76464930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76464930C>T	ENST00000389840.5	-	55	8629	c.8505G>A	c.(8503-8505)gtG>gtA	p.V2835V	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.V2844V					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GAACGTTCTTCACGGCAGCCT	0.542000													20	49					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30257204	30257204	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30257204G>A	ENST00000359358.4	-	8	2116	c.1678C>T	c.(1678-1680)Cga>Tga	p.R560*		NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	560						cytosol|endoplasmic reticulum membrane		p.R560*(1)		breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GGGCCACTTCGACCCTCCAAA	0.478000													30	85					0	0	1	0	0
HEATR6	63897	broad.mit.edu	37	17	58148147	58148147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58148147C>T	ENST00000184956.6	-	6	737	c.721G>A	c.(721-723)Ggt>Agt	p.G241S	HEATR6_ENST00000585976.1_Missense_Mutation_p.G241S	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	241							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			GACTGTATACCTTTTAATGCA	0.403000													25	65					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55935584	55935584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55935584C>T	ENST00000244728.5	-	21	2375	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K	COL21A1_ENST00000535941.1_Missense_Mutation_p.E660K|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.E60K|COL21A1_ENST00000370819.1_Missense_Mutation_p.E657K	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	660					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ATTCCAGGTTCACCTTTGCTT	0.328000													7	24					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30899683	30899683	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30899683G>C	ENST00000540456.1	-	2	210	c.17C>G	c.(16-18)tCc>tGc	p.S6C	SEC14L4_ENST00000392772.2_5'UTR|SEC14L4_ENST00000381982.3_Missense_Mutation_p.F37L|SEC14L4_ENST00000255858.7_Missense_Mutation_p.F37L			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	0						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	AGCGCAGGAGGAAGTAGTCAT	0.612000													14	42					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437709	120437709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120437709G>A	ENST00000369400.1	-	1	1409	c.1251C>T	c.(1249-1251)tcC>tcT	p.S417S		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	417	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		ACTCCTCTGTGGAACCACAGT	0.438000													50	155					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228247937	228247937	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228247937C>G	ENST00000366753.2	+	5	1137	c.1090C>G	c.(1090-1092)Cag>Gag	p.Q364E	WNT3A_ENST00000284523.1_3'UTR			P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	0					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				TTCAGCCCACCAGCCACCTCA	0.637000													32	77					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55070823	55070823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55070823C>T	ENST00000371316.3	+	13	1393	c.1311C>T	c.(1309-1311)gcC>gcT	p.A437A	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000343744.2_Silent_p.A437A	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	437	START.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						TGGATGCAGCCCAGGCCTTCC	0.617000													19	63					0	0	1	0	0
TMEM117	84216	broad.mit.edu	37	12	44770423	44770423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:44770423C>T	ENST00000266534.3	+	7	941	c.814C>T	c.(814-816)Cct>Tct	p.P272S	TMEM117_ENST00000536799.1_Missense_Mutation_p.P168S|TMEM117_ENST00000546978.1_3'UTR|TMEM117_ENST00000551577.1_Intron	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	272						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TGTAAATCTCCCTGGTTTGCA	0.388000													41	146					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16059904	16059904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16059904C>T	ENST00000322107.1	+	1	87	c.87C>T	c.(85-87)ttC>ttT	p.F29F		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						CCATCTTGTTCCTGCTGTACC	0.483000													96	245					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85382937	85382937	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85382937C>T	ENST00000258888.5	+	5	1200	c.1033C>T	c.(1033-1035)Cga>Tga	p.R345*		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	345	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCTAGGTGTCGAGAAGAAGA	0.632000													25	93					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17550869	17550869	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17550869C>T	ENST00000375471.4	+	4	446	c.354C>T	c.(352-354)tcC>tcT	p.S118S		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	118					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	CAGATATTTCCCTTGAGGTTG	0.592000													11	23					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36036035	36036035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36036035G>A	ENST00000282507.3	-	7	1438	c.1337C>T	c.(1336-1338)tCc>tTc	p.S446F	UGT3A2_ENST00000513300.1_Missense_Mutation_p.S412F|UGT3A2_ENST00000545528.1_Missense_Mutation_p.S144F	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	446						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGCGGGTGGGAGCGCAGGAT	0.587000													10	38					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48800332	48800332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48800332C>T	ENST00000315396.7	-	14	2596	c.1914G>A	c.(1912-1914)tcG>tcA	p.S638S		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	638	Ser-rich.									cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GGCCTCCGCTCGAATCAGACG	0.672000													11	140					0	0	1	0	0
ZNF207	7756	broad.mit.edu	37	17	30688494	30688494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:30688494C>T	ENST00000394670.4	+	6	728	c.559C>T	c.(559-561)Cat>Tat	p.H187Y	ZNF207_ENST00000341711.6_Missense_Mutation_p.H88Y|ZNF207_ENST00000577908.1_Missense_Mutation_p.H187Y|ZNF207_ENST00000321233.6_Intron|ZNF207_ENST00000394673.2_Missense_Mutation_p.H187Y|ZNF207_ENST00000342555.6_Missense_Mutation_p.H190Y	NM_001098507.1	NP_001091977.1	O43670	ZN207_HUMAN	zinc finger protein 207	184						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			CAGATTGCATCATCAGAGAAA	0.313000													20	25					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64589690	64589690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64589690C>T	ENST00000498707.1	-	25	3997	c.3655G>A	c.(3655-3657)Gag>Aag	p.E1219K	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.E1191K	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1219	TSP type-1 7.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAGGCACTCTCGTCAGCCACA	0.542000													6	70					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111564690	111564690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111564690C>T	ENST00000393934.3	+	4	1459	c.889C>T	c.(889-891)Cct>Tct	p.P297S	PLCXD2_ENST00000477665.1_3'UTR|PHLDB2_ENST00000393923.3_5'UTR	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	0					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CCCAGTTTATCCTTTGAGATT	0.468000													34	92					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10524919	10524919	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10524919C>T	ENST00000396560.2	+	3	669	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	ATF7IP2_ENST00000396559.1_Nonsense_Mutation_p.Q148*|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000356427.2_Nonsense_Mutation_p.Q148*|ATF7IP2_ENST00000324570.5_Nonsense_Mutation_p.Q148*	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						TTCTGAGCATCAGACAAATGT	0.448000													23	127					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47675066	47675066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47675066C>T	ENST00000283303.2	+	2	343	c.85C>T	c.(85-87)Cac>Tac	p.H29Y	GPR115_ENST00000371220.1_Missense_Mutation_p.H86Y|GPR115_ENST00000327753.3_Missense_Mutation_p.H29Y	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	29					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						ATCCAAGATTCACCTAAAAGT	0.383000													8	100					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135693067	135693067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135693067C>T	ENST00000513104.1	-	2	291	c.9G>A	c.(7-9)agG>agA	p.R3R	TRPC7_ENST00000426057.2_Silent_p.R3R|TRPC7_ENST00000355180.3_Silent_p.R3R	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	3					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGGTGCTGTTCCTCAACCTAT	0.527000													11	29					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43052675	43052675	+	Missense_Mutation	SNP	G	G	A	rs145902391		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43052675G>A	ENST00000316099.3	+	8	999	c.910G>A	c.(910-912)Gat>Aat	p.D304N	HNF4A_ENST00000415691.1_Missense_Mutation_p.D304N|HNF4A_ENST00000457232.1_Missense_Mutation_p.D282N|HNF4A_ENST00000443598.2_Missense_Mutation_p.D304N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	304					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGGGCTGAGCGATCCAGGGAA	0.607000													9	22					0	0	1	0	0
FMR1NB	158521	broad.mit.edu	37	X	147062951	147062951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:147062951G>A	ENST00000370467.3	+	1	103	c.29G>A	c.(28-30)gGg>gAg	p.G10E		NM_152578.2	NP_689791.1	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	10						integral to membrane				breast(2)|cervix(1)|endometrium(3)|large_intestine(7)|lung(10)|ovary(1)|skin(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGCGAAGGGGAGGAATAGG	0.597000													17	37					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13792151	13792151	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13792151G>A	ENST00000265104.4	-	50	8504	c.8400C>T	c.(8398-8400)gtC>gtT	p.V2800V		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2800	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTCCCTGCCAGACCCGAGAAA	0.403000									Kartagener syndrome				23	41					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414808	105414808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105414808G>A	ENST00000333244.5	-	7	7099	c.6980C>T	c.(6979-6981)tCg>tTg	p.S2327L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2327						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CACCCCAAACGACAGCATCTT	0.602000													33	362					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25326342	25326342	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25326342C>T	ENST00000546682.1	+	0	42				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TGTGGGGGCTCCTCCAGAGGC	0.507000													16	21					0	0	1	0	0
CERS6	253782	broad.mit.edu	37	2	169622102	169622102	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169622102G>A	ENST00000305747.6	+	9	1433	c.845_splice	c.e9-1	p.W282_splice	CERS6_ENST00000392687.4_Splice_Site_p.W282_splice	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	282	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										TTTTCCTTAGGGTGTTAAATA	0.418000													23	76					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68702871	68702871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68702871C>T	ENST00000255078.3	+	12	1848	c.1737C>T	c.(1735-1737)ttC>ttT	p.F579F	IGHMBP2_ENST00000541229.1_3'UTR	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	579					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TACTGTCCTTCGTCAGATCCA	0.537000													9	70					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100154749	100154749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100154749G>A	ENST00000263174.4	+	7	1308	c.933G>A	c.(931-933)gaG>gaA	p.E311E	PALMD_ENST00000605497.1_Silent_p.E311E	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	311					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		GTCTTTCAGAGGAAAGGGGAA	0.443000													15	83					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76790259	76790259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76790259C>T	ENST00000287239.4	+	18	6166	c.5677C>T	c.(5677-5679)Ccg>Tcg	p.P1893S	KAT6B_ENST00000372714.1_Missense_Mutation_p.P1601S|KAT6B_ENST00000372725.1_Missense_Mutation_p.P1601S|KAT6B_ENST00000372711.1_Missense_Mutation_p.P1710S|KAT6B_ENST00000372724.1_Missense_Mutation_p.P1601S	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	1893	Interaction with RUNX1 and RUNX2.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										GAATCTGCCGCCGCCTCTTTT	0.552000													80	199					0	0	1	0	0
PRDM12	59335	broad.mit.edu	37	9	133540058	133540058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133540058C>T	ENST00000253008.2	+	1	78	c.18C>T	c.(16-18)ctC>ctT	p.L6L		NM_021619.2	NP_067632.2	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	6					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GCTCCGTGCTCCCGGCTGAGG	0.746000													8	11					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20955880	20955880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20955880G>A	ENST00000261383.3	-	58	11448	c.11449C>T	c.(11449-11451)Ctg>Ttg	p.L3817L	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3817					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCCTCAAACAGCTGGTTGGTT	0.547000													24	54					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167279836	167279836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167279836C>T	ENST00000409855.1	-	18	3086	c.2960G>A	c.(2959-2961)tGg>tAg	p.W987*		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	987					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						ATATGCCATCCATTTTAGAAG	0.318000													23	51					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	93879776	93879776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:93879776G>A	ENST00000377047.4	+	1	682	c.67G>A	c.(67-69)Gcg>Acg	p.A23T		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	23						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CCCCGCCGGGGCGGATGTGAA	0.627000											OREG0022460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	53					0	0	1	0	0
SOX11	6664	broad.mit.edu	37	2	5832928	5832928	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:5832928A>G	ENST00000322002.3	+	1	130	c.75A>G	c.(73-75)gaA>gaG	p.E25E		NM_003108.3	NP_003099.1	P35716	SOX11_HUMAN	SRY (sex determining region Y)-box 11	25					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(5)|cervix(1)|endometrium(1)|liver(1)|lung(4)|stomach(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		AGGAGGGCGAATTCATGGCTT	0.657000													5	22					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860848	16860848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16860848C>T	ENST00000524140.2	+	6	1813	c.1395C>T	c.(1393-1395)atC>atT	p.I465I	NWD1_ENST00000523826.1_Silent_p.I259I|NWD1_ENST00000379808.3_Silent_p.I465I|NWD1_ENST00000552788.1_Silent_p.I465I|NWD1_ENST00000339803.6_Silent_p.I330I|NWD1_ENST00000549814.1_Silent_p.I465I	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	465	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGCACCTCATCCTCTCAGCTT	0.642000													8	124					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189612096	189612096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189612096C>T	ENST00000264731.3	+	14	1937	c.1848C>T	c.(1846-1848)ctC>ctT	p.L616L	TP63_ENST00000449992.1_Silent_p.L437L|TP63_ENST00000320472.5_3'UTR|TP63_ENST00000456148.1_Silent_p.L518L|TP63_ENST00000382063.4_Silent_p.L531L|TP63_ENST00000354600.5_Silent_p.L522L|TP63_ENST00000440651.2_Silent_p.L612L	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	616	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CTTCTCATCTCCTGCGGACCC	0.572000										HNSCC(45;0.13)			25	88					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178555048	178555048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178555048G>A	ENST00000251582.7	-	17	2630	c.2529C>T	c.(2527-2529)gtC>gtT	p.V843V		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	843	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TGTTGTCGTCGACATTCAGTG	0.582000													11	112					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70635015	70635015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70635015C>T	ENST00000381269.2	-	2	878	c.125G>A	c.(124-126)gGg>gAg	p.G42E	SLC8A3_ENST00000528359.1_Missense_Mutation_p.G42E|SLC8A3_ENST00000357887.3_Missense_Mutation_p.G42E|SLC8A3_ENST00000534137.1_Missense_Mutation_p.G42E|SLC8A3_ENST00000356921.2_Missense_Mutation_p.G42E	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	42					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ATTGTTCTGCCCTGTGCTTGG	0.567000													13	42					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93125795	93125795	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93125795C>T	ENST00000216487.7	+	7	2475	c.2316C>T	c.(2314-2316)tcC>tcT	p.S772S	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	772	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				TCTACGACTCCATGGCCCTCG	0.572000													28	95					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43120225	43120225	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43120225G>A	ENST00000267890.6	-	6	546	c.438C>T	c.(436-438)aaC>aaT	p.N146N	TTBK2_ENST00000567274.1_Intron|TTBK2_ENST00000567840.1_Silent_p.N146N	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	146	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CCATAGCGAAGTTCGACTAGA	0.343000													9	63					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64984868	64984868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:64984868C>T	ENST00000394156.3	-	12	2149	c.1696G>A	c.(1696-1698)Gac>Aac	p.D566N	CDH11_ENST00000268603.4_Missense_Mutation_p.D566N|CDH11_ENST00000566827.1_Missense_Mutation_p.D440N			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	566	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AGGTACAAGTCCTGCTTCTGC	0.602000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			8	38					0	0	1	0	0
ULBP2	80328	broad.mit.edu	37	6	150266593	150266593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:150266593G>A	ENST00000367351.3	+	2	307	c.234G>A	c.(232-234)ggG>ggA	p.G78G		NM_025217.2	NP_079493.1	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2	78	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		GTCCCCTGGGGAAGAAACTAA	0.512000													78	156					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13029765	13029765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:13029765G>A	ENST00000399002.2	+	2	564	c.290G>A	c.(289-291)aGa>aAa	p.R97K	SPTLC3_ENST00000378194.4_Missense_Mutation_p.R97K|SPTLC3_ENST00000476791.1_3'UTR	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	97					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	GCTGTGGAAAGAAAAGAACAA	0.428000													22	79					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133900607	133900607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133900607G>A	ENST00000220616.4	+	10	2595	c.2555G>A	c.(2554-2556)gGg>gAg	p.G852E	TG_ENST00000377869.1_Missense_Mutation_p.G852E	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	852	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCACTGGAAGGGAAACGGCCC	0.537000													19	56					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51697238	51697238	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51697238C>T	ENST00000409535.1	+	22	4331	c.4206C>T	c.(4204-4206)tcC>tcT	p.S1402S	RAD54L2_ENST00000296477.3_Silent_p.S1096S	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	1402						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CTTTTCCTTCCCCTGTCTTGC	0.577000													8	114					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36897586	36897586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36897586G>A	ENST00000301807.6	-	12	3742	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F	TRANK1_ENST00000429976.2_Silent_p.F1165F|TRANK1_ENST00000428977.2_Silent_p.F615F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1165					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAAGCTCAATGAAATTCCTTT	0.483000													54	117					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196801453	196801453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196801453C>T	ENST00000312428.6	-	20	3242	c.3142G>A	c.(3142-3144)Gaa>Aaa	p.E1048K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1048	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCAAAAGTTCATTAGATTTT	0.303000													6	66					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35144275	35144275	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:35144275G>A	ENST00000436258.1	-	0	1791																											GCATATCAAGGAAGCCATAAC	0.388000													12	40					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102496012	102496012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102496012G>A	ENST00000260228.2	-	1	51	c.39C>T	c.(37-39)ctC>ctT	p.L13L	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	13					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AAGCCATGATGAGGAAGACAG	0.542000													9	63					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43821548	43821548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43821548G>A	ENST00000382031.1	+	5	8622	c.8591G>A	c.(8590-8592)gGa>gAa	p.G2864E	MAP1A_ENST00000399453.1_Missense_Mutation_p.G2626E|MAP1A_ENST00000300231.5_Missense_Mutation_p.G2626E			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2626						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GATCTTCGGGGAAAACGCTCA	0.657000													32	66					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46930133	46930133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46930133G>A	ENST00000262738.3	-	1	2934	c.2935C>T	c.(2935-2937)Ctt>Ttt	p.L979F	CELSR1_ENST00000395964.1_Missense_Mutation_p.L979F	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	979	Cadherin 7.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GAGGCGCTAAGGGGAGTGGGA	0.567000													17	100					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60785798	60785798	+	Silent	SNP	C	C	T	rs111507268	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60785798C>T	ENST00000313421.7	+	12	2061	c.1875C>T	c.(1873-1875)tcC>tcT	p.S625S	CD6_ENST00000344028.5_Silent_p.S593S|CD6_ENST00000452451.2_Intron|CD6_ENST00000352009.5_Intron|CD6_ENST00000346437.4_Silent_p.S552S	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	625					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						GCACCTCATCCGGGGAGTGGT	0.627000													8	20					0	0	1	0	0
PSEN2	5664	broad.mit.edu	37	1	227071564	227071564	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:227071564C>T	ENST00000366782.1	+	5	899	c.399C>T	c.(397-399)atC>atT	p.I133I	PSEN2_ENST00000391872.2_Silent_p.I133I|PSEN2_ENST00000340188.4_Silent_p.I100I|PSEN2_ENST00000422240.2_Silent_p.I100I|PSEN2_ENST00000366783.3_Silent_p.I100I			P49810	PSN2_HUMAN	presenilin 2 (Alzheimer disease 4)	100					amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding	p.I100I(1)		cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|urinary_tract(1)	20		Prostate(94;0.0771)				TGTGCATGATCGTGGTGGTAG	0.607000													28	83					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38995970	38995970	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38995970G>A	ENST00000355481.4	+	53	8463	c.8332G>A	c.(8332-8334)Gga>Aga	p.G2778R	RYR1_ENST00000359596.3_Missense_Mutation_p.G2778R|RYR1_ENST00000360985.3_Missense_Mutation_p.G2778R	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2778	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTGGTCCTATGGAGAGAACAT	0.602000													12	20					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202404	56202404	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56202404G>A	ENST00000361673.3	-	5	5228	c.5015C>T	c.(5014-5016)cCa>cTa	p.P1672L		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1672							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTTTTGACATGGATCCTGCAG	0.532000													21	111					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076695	9076695	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9076695G>A	ENST00000397910.4	-	3	10954	c.10751C>T	c.(10750-10752)tCt>tTt	p.S3584F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3585	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGCTGTGGAAGACCAGGTGGA	0.493000													27	69					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955590	18955590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18955590C>T	ENST00000302797.3	-	1	966	c.742G>A	c.(742-744)Gtc>Atc	p.V248I		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	248					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CAAAATAAGACTTCCCTGTCC	0.473000													17	40					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39228062	39228062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39228062C>T	ENST00000340369.3	-	2	3103	c.2875G>A	c.(2875-2877)Gag>Aag	p.E959K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.E959K	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	959							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGGGCCCCCTCGCTGGCTGGC	0.657000													21	58					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87965964	87965964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:87965964C>T	ENST00000369577.3	+	8	2660	c.2617C>T	c.(2617-2619)Cct>Tct	p.P873S	ZNF292_ENST00000339907.4_Missense_Mutation_p.P868S	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ATCTATGCTTCCTTCAGAAAA	0.398000													5	43					0	0	1	0	0
IGLV3-9	28804	broad.mit.edu	37	22	23162204	23162204	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23162204G>A	ENST00000390316.2	+	0	412																											CCCAAGCCGGGGATGAGGCTG	0.557000													21	56					0	0	1	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140865966	140865966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140865966C>T	ENST00000306593.1	+	1	1226	c.1226C>T	c.(1225-1227)aCt>aTt	p.T409I	PCDHGA11_ENST00000518882.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCTGGTGACTGCTGGACCC	0.527000													24	47					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71602047	71602047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71602047C>T	ENST00000355962.4	-	12	1498	c.1365G>A	c.(1363-1365)taG>taA	p.*455*	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	0					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GGATGCAGGCCTATTTATCAC	0.597000													17	59					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215833488	215833488	+	Missense_Mutation	SNP	G	G	A	rs144770649	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215833488G>A	ENST00000272895.7	-	38	5953	c.5734C>T	c.(5734-5736)Cgt>Tgt	p.R1912C	ABCA12_ENST00000389661.4_Missense_Mutation_p.R1594C	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1912					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ATATCAAAACGAAGGTCTTTT	0.338000													41	152					0	0	1	0	0
BMF	90427	broad.mit.edu	37	15	40398107	40398107	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40398107G>A	ENST00000354670.4	-	3	415	c.181C>T	c.(181-183)Cga>Tga	p.R61*	BMF_ENST00000561282.1_Nonsense_Mutation_p.R61*|BMF_ENST00000561360.1_Nonsense_Mutation_p.R61*|BMF_ENST00000558774.1_Nonsense_Mutation_p.R61*|BMF_ENST00000431415.3_Nonsense_Mutation_p.R61*|BMF_ENST00000559701.1_Nonsense_Mutation_p.R61*|BMF_ENST00000220446.4_Nonsense_Mutation_p.R61*|BMF_ENST00000397573.1_Nonsense_Mutation_p.R61*	NM_001003940.1	NP_001003940.1	Q96LC9	BMF_HUMAN	Bcl2 modifying factor	61				R -> Q (in Ref. 4; AAH69328).	activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	6		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		CTGGTGGGTCGAAGGCCAGGG	0.627000													25	60					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126137028	126137028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:126137028G>A	ENST00000299308.3	+	8	1949	c.1941G>A	c.(1939-1941)acG>acA	p.T647T	TMEM132B_ENST00000535886.1_Silent_p.T159T	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	647						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CTGAGAAGACGGTGATTGTCC	0.572000													15	32					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66083828	66083828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66083828G>A	ENST00000311330.3	-	1	687	c.671C>T	c.(670-672)tCa>tTa	p.S224L	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	224	Sushi.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	CCCAGCCCGTGACCAGCCCAC	0.682000													15	56					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583873	88583873	+	Missense_Mutation	SNP	G	G	A	rs149603030		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88583873G>A	ENST00000339673.6	+	6	1042	c.943G>A	c.(943-945)Ggt>Agt	p.G315S	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.G299S|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	315					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding	p.G315S(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		AGACAGCAAGGGTGACTCTCA	0.512000													6	80					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8331622	8331622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8331622C>T	ENST00000381196.4	-	41	6037	c.5494G>A	c.(5494-5496)Gaa>Aaa	p.E1832K	PTPRD_ENST00000397611.3_Missense_Mutation_p.E1422K|PTPRD_ENST00000397617.3_Missense_Mutation_p.E1425K|PTPRD_ENST00000540109.1_Missense_Mutation_p.E1832K|PTPRD_ENST00000360074.4_Missense_Mutation_p.E1819K|PTPRD_ENST00000537002.1_Missense_Mutation_p.E1422K|PTPRD_ENST00000358503.5_Missense_Mutation_p.E1810K|PTPRD_ENST00000486161.1_Missense_Mutation_p.E1425K|PTPRD_ENST00000356435.5_Missense_Mutation_p.E1832K|PTPRD_ENST00000355233.5_Missense_Mutation_p.E1426K|PTPRD_ENST00000397606.3_Missense_Mutation_p.E1425K	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1832	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CCAAACTGTTCTTTTGTTTTA	0.433000										TSP Lung(15;0.13)			33	63					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34782179	34782179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34782179G>A	ENST00000338074.2	+	12	1507	c.1346G>A	c.(1345-1347)gGg>gAg	p.G449E	EPB41L1_ENST00000373946.3_Missense_Mutation_p.G418E|EPB41L1_ENST00000373950.2_Missense_Mutation_p.G352E|EPB41L1_ENST00000441639.1_Missense_Mutation_p.G387E|EPB41L1_ENST00000202028.5_Missense_Mutation_p.G387E|EPB41L1_ENST00000373941.1_Missense_Mutation_p.G449E	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	449					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					CATGATGCAGGGCCTGACGGT	0.602000													9	28					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155250772	155250772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155250772C>T	ENST00000357232.3	-	11	2455	c.2456G>A	c.(2455-2457)cGa>cAa	p.R819Q	DCHS2_ENST00000339452.1_Missense_Mutation_p.R1274Q	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	819	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGTGGCGTTTCGTGGTGGGGA	0.542000													22	41					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73616252	73616252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73616252C>T	ENST00000261917.3	-	8	3175	c.2182G>A	c.(2182-2184)Gac>Aac	p.D728N		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	728					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GAGTTGAGGTCGTGCTGGACT	0.592000													9	115					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169099050	169099050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169099050G>A	ENST00000359299.3	+	8	730	c.544G>A	c.(544-546)Gaa>Aaa	p.E182K		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	182							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		GGTCCTATGGGAAGCCTGTCA	0.502000													18	93					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39885298	39885298	+	Silent	SNP	C	C	T	rs139289744	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39885298C>T	ENST00000260356.5	+	18	3030	c.2865C>T	c.(2863-2865)acC>acT	p.T955T		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	955					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TCAGTGAGACCGATTTCCGCC	0.502000													13	44					0	0	1	0	0
GFRA3	2676	broad.mit.edu	37	5	137600082	137600082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137600082G>A	ENST00000274721.3	-	2	493	c.247C>T	c.(247-249)Cct>Tct	p.P83S	GFRA3_ENST00000378362.3_Missense_Mutation_p.P83S	NM_001496.3	NP_001487.2	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3	83					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CAGTCAGCAGGGACCGAAGGC	0.597000													27	57					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24256502	24256502	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24256502G>A	ENST00000538205.1	+	10	1188	c.641G>A	c.(640-642)tGg>tAg	p.W214*	ADAMDEC1_ENST00000522298.1_Nonsense_Mutation_p.W214*|ADAMDEC1_ENST00000256412.4_Nonsense_Mutation_p.W293*|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	293					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TTCCTGAGATGGCACAGTTCT	0.507000													16	44					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12353605	12353605	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12353605C>T	ENST00000358136.3	+	24	6007	c.5877C>T	c.(5875-5877)ctC>ctT	p.L1959L	VPS13D_ENST00000356315.4_Silent_p.L1959L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1959					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACCCTCTGCTCCGGAGAGAAC	0.483000													10	53					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228309	142228309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142228309G>A	ENST00000519067.1	-	4	1580	c.1277C>T	c.(1276-1278)aCc>aTc	p.T426I	SLC45A4_ENST00000024061.3_Missense_Mutation_p.T426I|SLC45A4_ENST00000433583.2_Missense_Mutation_p.T419I|SLC45A4_ENST00000517878.1_Missense_Mutation_p.T477I			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	477					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GCTGGAGGTGGTGGCCCCGCT	0.677000													6	29					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50367226	50367226	+	Silent	SNP	C	C	T	rs143481476		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50367226C>T	ENST00000315520.5	+	1	607	c.270C>T	c.(268-270)ctC>ctT	p.L90L	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	90					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						TGGCCTTCCTCGTAGGCTCCC	0.667000													22	52					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94548945	94548945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94548945C>T	ENST00000370225.3	-	7	907	c.821G>A	c.(820-822)gGa>gAa	p.G274E	ABCA4_ENST00000535735.1_Missense_Mutation_p.G274E	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	274					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TAATATTCCTCCCCAAGATCT	0.353000													19	339					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117685228	117685228	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117685228G>A	ENST00000317775.6	-	18	3433	c.2748C>T	c.(2746-2748)atC>atT	p.I916I	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.I950I	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	916	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCATCTTCAGGATCCTCTCCC	0.557000													40	85					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231972	7231972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:7231972C>T	ENST00000383467.2	+	1	850	c.836C>T	c.(835-837)cCt>cTt	p.P279L		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	279										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						TTATCCAAGCCTCTGCCGGAG	0.597000													73	196					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3740659	3740659	+	Missense_Mutation	SNP	C	C	T	rs144286949		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3740659C>T	ENST00000541714.2	+	14	2203	c.1741C>T	c.(1741-1743)Cgt>Tgt	p.R581C	TJP3_ENST00000589378.1_Missense_Mutation_p.R590C|TJP3_ENST00000539908.2_Missense_Mutation_p.R545C|TJP3_ENST00000262968.9_Missense_Mutation_p.R614C|TJP3_ENST00000382008.3_Missense_Mutation_p.R595C|TJP3_ENST00000587686.1_Missense_Mutation_p.R600C	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	595						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGGTCTTCGTCGAGGAGC	0.692000													12	18					0	0	1	0	0
SOST	50964	broad.mit.edu	37	17	41836020	41836020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:41836020C>T	ENST00000301691.2	-	1	136	c.90G>A	c.(88-90)aaG>aaA	p.K30K		NM_025237.2	NP_079513.1	Q9BQB4	SOST_HUMAN	sclerostin	30					negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of ossification|negative regulation of protein complex assembly|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway		heparin binding|protein binding			large_intestine(2)|lung(3)|prostate(1)	6		Breast(137;0.00725)		UCEC - Uterine corpus endometrioid carcinoma (308;0.177)|BRCA - Breast invasive adenocarcinoma(366;0.0741)		TGGCATCATTCTTGAACGCCT	0.622000													34	36					0	0	1	0	0
REM1	28954	broad.mit.edu	37	20	30072045	30072045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30072045G>A	ENST00000201979.2	+	5	1002	c.709G>A	c.(709-711)Gag>Aag	p.E237K		NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	237					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CGAGCTCTTCGAGGGCGTGGT	0.701000													6	13					0	0	1	0	0
CYP2A6	1548	broad.mit.edu	37	19	41354158	41354158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41354158C>T	ENST00000301141.5	-	4	640	c.620G>A	c.(619-621)gGa>gAa	p.G207E	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	207					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	CTGGAAGATTCCTAGCATCAT	0.567000													40	110					0	0	1	0	0
TBCB	1155	broad.mit.edu	37	19	36616633	36616633	+	Silent	SNP	C	C	T	rs146159771		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36616633C>T	ENST00000221855.3	+	6	1259	c.684C>T	c.(682-684)gtC>gtT	p.V228V	TBCB_ENST00000589996.1_3'UTR|TBCB_ENST00000586868.1_3'UTR|TBCB_ENST00000585746.1_Silent_p.V177V	NM_001281.2	NP_001272.2	Q99426	TBCB_HUMAN	tubulin folding cofactor B	228					'de novo' posttranslational protein folding|cell differentiation|nervous system development	cytoplasm|microtubule	protein binding			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGCCAGCAGTCGTGACGGTGG	0.572000													97	224					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31422420	31422420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31422420C>T	ENST00000389202.2	+	13	1429	c.1380C>T	c.(1378-1380)tcC>tcT	p.S460S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	460					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TCGGGGCCTCCCTCTGCTCTG	0.662000													20	115					0	0	1	0	0
ATP1A1	476	broad.mit.edu	37	1	116943869	116943869	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:116943869C>T	ENST00000537345.1	+	20	3199	c.2836C>T	c.(2836-2838)Cag>Tag	p.Q946*	ATP1A1_ENST00000295598.5_Nonsense_Mutation_p.Q946*|ATP1A1_ENST00000369496.4_Nonsense_Mutation_p.Q915*	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	946					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TTCGGTCTTCCAGCAGGGGAT	0.488000													8	59					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75651681	75651681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75651681G>A	ENST00000565683.1	-	17	2058	c.2047C>T	c.(2047-2049)Cgt>Tgt	p.R683C	MAN2C1_ENST00000563622.1_Silent_p.F579F|MAN2C1_ENST00000569482.1_Silent_p.F678F|MAN2C1_ENST00000267978.5_Silent_p.F678F	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	664					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						CTTGCACTACGAACACAGGCT	0.622000													15	60					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56419205	56419205	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56419205C>T	ENST00000588751.1	-	7	2424	c.2400G>A	c.(2398-2400)ctG>ctA	p.L800L	NLRP13_ENST00000342929.3_Silent_p.L800L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	800							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CTTTAAGAATCAGGGGGACAG	0.498000													40	87					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183605973	183605973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:183605973C>T	ENST00000264065.6	+	13	1496	c.1081C>T	c.(1081-1083)Cgt>Tgt	p.R361C		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	361					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTTTAAGGATCGTTTGGCTCA	0.318000													6	46					0	0	1	0	0
VPS51	738	broad.mit.edu	37	11	64876880	64876880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64876880C>T	ENST00000279281.3	+	6	1664	c.1572C>T	c.(1570-1572)ctC>ctT	p.L524L	VPS51_ENST00000527646.1_3'UTR	NM_013265.2	NP_037397.2			vacuolar protein sorting 51 homolog (S. cerevisiae)																		CTGCCCTGCTCCTGCTGCTCT	0.612000													8	72					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48145489	48145489	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48145489C>T	ENST00000311303.3	-	15	2554	c.2209_splice	c.e15+1	p.V737_splice	ABCC12_ENST00000416054.1_Intron|ABCC12_ENST00000448542.1_Intron	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	737						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GGATTCTAACCGATTATACCA	0.448000													82	339					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40739002	40739002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40739002C>T	ENST00000373198.3	-	24	3526	c.3291G>A	c.(3289-3291)ccG>ccA	p.P1097P	PTPRT_ENST00000373187.1_Silent_p.P1075P|PTPRT_ENST00000373193.3_Silent_p.P1078P|PTPRT_ENST00000373201.1_Silent_p.P1065P|PTPRT_ENST00000373184.1_Silent_p.P1085P|PTPRT_ENST00000356100.2_Silent_p.P1084P|PTPRT_ENST00000373190.1_Silent_p.P1074P	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1075	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCCAGCTTCCGGGGGGTTGA	0.627000													13	50					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8500760	8500760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8500760C>T	ENST00000381196.4	-	21	2665	c.2122G>A	c.(2122-2124)Gaa>Aaa	p.E708K	PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.E708K|PTPRD_ENST00000360074.4_Missense_Mutation_p.E695K|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.E695K|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.E708K|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000397606.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	708					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATACCATCTTCATTGGTTCGA	0.488000										TSP Lung(15;0.13)			37	60					0	0	1	0	0
CRYBA4	1413	broad.mit.edu	37	22	27018589	27018589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:27018589G>A	ENST00000354760.3	+	2	64	c.29G>A	c.(28-30)gGa>gAa	p.G10E	CRYBA4_ENST00000466315.1_3'UTR	NM_001886.2	NP_001877.1	P53673	CRBA4_HUMAN	crystallin, beta A4	10	N-terminal arm.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens			large_intestine(6)|liver(1)|lung(6)|skin(3)|urinary_tract(2)	18						AAGTCAGCGGGACCCTGGAAG	0.542000													7	62					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160109744	160109744	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160109744C>T	ENST00000361216.3	+	22	3093	c.3004C>T	c.(3004-3006)Cga>Tga	p.R1002*	ATP1A2_ENST00000392233.3_Nonsense_Mutation_p.R991*	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1002					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.R1002R(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGATGAGGTCCGAAAGCTCAT	0.582000													29	122					0	0	1	0	0
ZNF18	7566	broad.mit.edu	37	17	11881772	11881772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11881772G>A	ENST00000322748.3	-	9	1756	c.1152C>T	c.(1150-1152)acC>acT	p.T384T	ZNF18_ENST00000580613.1_Intron|ZNF18_ENST00000454073.3_Silent_p.T383T|ZNF18_ENST00000580306.1_Silent_p.T384T	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	384					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		CAAGCCACATGGTGGACATTT	0.532000													19	63					0	0	1	0	0
NRG2	9542	broad.mit.edu	37	5	139231339	139231339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139231339G>A	ENST00000541337.1	-	7	1653	c.1424C>T	c.(1423-1425)tCa>tTa	p.S475L	NRG2_ENST00000289409.4_Missense_Mutation_p.S535L|NRG2_ENST00000358522.3_Missense_Mutation_p.S543L|NRG2_ENST00000545385.1_Missense_Mutation_p.S543L|NRG2_ENST00000361474.1_Missense_Mutation_p.S541L|NRG2_ENST00000340391.3_Missense_Mutation_p.S338L|NRG2_ENST00000394770.1_3'UTR|CTB-35F21.4_ENST00000504413.1_RNA|NRG2_ENST00000289422.7_Missense_Mutation_p.S549L	NM_001184935.1	NP_001171864.1	O14511	NRG2_HUMAN	neuregulin 2	541					embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	25			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTACCCACTGATGATAGCAT	0.632000													18	51					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21136525	21136525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21136525C>T	ENST00000261383.3	-	9	1374	c.1375G>A	c.(1375-1377)Gac>Aac	p.D459N	CTC-508F8.1_ENST00000575612.1_RNA|DNAH3_ENST00000415178.1_Missense_Mutation_p.D459N	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	459	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GAAACGAGGTCCTCAAGTGAC	0.453000													14	88					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651392	1651392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1651392G>A	ENST00000399676.2	+	1	360	c.322G>A	c.(322-324)Gcc>Acc	p.A108T		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	108	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GTCCAAGGGGGCCTGTGGCTC	0.687000													51	108					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21175855	21175855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21175855G>A	ENST00000381541.3	+	5	618	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	SLCO1B7_ENST00000554957.1_Missense_Mutation_p.E185K|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.E138K|SLCO1B3_ENST00000553473.1_Intron																							TGGCATAGGGGAAACCCCCAT	0.368000													36	101					0	0	1	0	0
RASIP1	54922	broad.mit.edu	37	19	49227976	49227976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49227976C>T	ENST00000222145.4	-	9	2573	c.2369G>A	c.(2368-2370)cGa>cAa	p.R790Q		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	790	Dilute.				signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		ACCTTCACCTCGTTCCATCAG	0.552000													27	95					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38993182	38993182	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38993182G>A	ENST00000355481.4	+	48	7781	c.7650G>A	c.(7648-7650)ctG>ctA	p.L2550L	RYR1_ENST00000359596.3_Silent_p.L2550L|RYR1_ENST00000360985.3_Silent_p.L2550L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2550	6 X approximate repeats.		L -> V.		muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGCTGGCGCTGAACCGCTACC	0.652000													5	25					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285203	223285203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:223285203G>A	ENST00000540964.1	-	4	1632	c.1171C>T	c.(1171-1173)Ctc>Ttc	p.L391F	TLR5_ENST00000342210.6_Missense_Mutation_p.L391F			O60602	TLR5_HUMAN	toll-like receptor 5	391					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		TTGTCTCGGAGATCCAAGGTC	0.373000													8	109					0	0	1	0	0
BCL7A	605	broad.mit.edu	37	12	122481924	122481924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122481924C>T	ENST00000538010.1	+	4	3074	c.404C>T	c.(403-405)gCc>gTc	p.A135V	BCL7A_ENST00000261822.4_Missense_Mutation_p.A135V	NM_020993.3	NP_066273.1	Q4VC05	BCL7A_HUMAN	B-cell CLL/lymphoma 7A	135					negative regulation of transcription, DNA-dependent					haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000202)|Epithelial(86;0.000386)|BRCA - Breast invasive adenocarcinoma(302;0.231)		GTGGATGAGGCCCAGGCTGAT	0.652000			T	MYC	BNHL								8	70					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40947690	40947690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40947690G>A	ENST00000246914.5	+	16	3091	c.3070G>A	c.(3070-3072)Gaa>Aaa	p.E1024K		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1024					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTCATCCAAGGAACCGGCTGA	0.547000													29	29					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41008206	41008206	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41008206C>T	ENST00000352632.3	+	9	1155	c.1069C>T	c.(1069-1071)Ctg>Ttg	p.L357L	SPTBN4_ENST00000598249.1_Silent_p.L357L|SPTBN4_ENST00000595535.1_Silent_p.L357L|SPTBN4_ENST00000344104.3_Silent_p.L357L|SPTBN4_ENST00000338932.3_Silent_p.L357L			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	357					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTATTGCACGCTGGAGAAGCC	0.607000													24	49					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24974859	24974859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:24974859C>T	ENST00000405141.1	+	21	4426	c.3715C>T	c.(3715-3717)Ccc>Tcc	p.P1239S	NCOA1_ENST00000538539.1_Missense_Mutation_p.P1239S|NCOA1_ENST00000288599.5_Missense_Mutation_p.P1239S|NCOA1_ENST00000407230.1_Missense_Mutation_p.P1088S|NCOA1_ENST00000406961.1_Missense_Mutation_p.P1239S|NCOA1_ENST00000395856.3_Missense_Mutation_p.P1239S|NCOA1_ENST00000348332.3_Missense_Mutation_p.P1239S			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	1239									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAATGGTTCCCCAAGGTGA	0.418000			T	PAX3	alveolar rhadomyosarcoma								33	63					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104902005	104902005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:104902005G>A	ENST00000533400.1	-	4	375	c.340C>T	c.(340-342)Cct>Tct	p.P114S	CASP1_ENST00000525825.1_Missense_Mutation_p.P93S|CASP1_ENST00000446369.1_Missense_Mutation_p.P21S|CASP1_ENST00000436863.3_Missense_Mutation_p.P114S|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000353247.5_Intron|CASP1_ENST00000531166.1_Intron|CASP1_ENST00000598974.1_Missense_Mutation_p.P114S|CASP1_ENST00000594519.1_Missense_Mutation_p.P21S|CASP1_ENST00000534497.1_Missense_Mutation_p.P21S|CASP1_ENST00000593315.1_Missense_Mutation_p.P93S|CASP1_ENST00000393136.4_Missense_Mutation_p.P93S|CASP1_ENST00000528974.1_Missense_Mutation_p.P75S|CASP1_ENST00000527979.1_Missense_Mutation_p.P77S|CASP1_ENST00000526568.1_Missense_Mutation_p.P21S	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	114					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	ACTGCCTGAGGAGCTGCAAGA	0.483000													11	33					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156667159	156667159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156667159C>T	ENST00000422843.3	+	10	1091	c.939C>T	c.(937-939)ttC>ttT	p.F313F		NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	313	SH2.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTATGTGTTCGATTCCATCC	0.458000			T	SYK	peripheral T-cell lymphoma								19	81					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70420231	70420231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70420231G>A	ENST00000381280.4	+	3	613	c.360G>A	c.(358-360)gaG>gaA	p.E120E	SMOC1_ENST00000361956.3_Silent_p.E120E	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	120	Thyroglobulin type-1 1.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		AGTGTGGCGAGGATGGCTCCT	0.617000													11	82					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211456679	211456679	+	Missense_Mutation	SNP	G	G	A	rs149930500		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211456679G>A	ENST00000233072.5	+	10	1268	c.1072G>A	c.(1072-1074)Gat>Aat	p.D358N	CPS1_ENST00000430249.2_Missense_Mutation_p.D364N	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	358	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GAATGTCAACGATCAAACAAA	0.378000													8	40					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8435173	8435173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8435173G>A	ENST00000447869.1	-	11	2131	c.1213C>T	c.(1213-1215)Cca>Tca	p.P405S	STK33_ENST00000396673.1_Intron|STK33_ENST00000315204.1_Missense_Mutation_p.P405S|STK33_ENST00000396672.1_Missense_Mutation_p.P405S|STK33_ENST00000473980.1_5'UTR|STK33_ENST00000358872.3_Missense_Mutation_p.P218S|STK33_ENST00000534493.1_Missense_Mutation_p.P364S			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	405						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		ACACTTTCTGGGTTATTTTTC	0.373000													58	124					0	0	1	0	0
CDSN	1041	broad.mit.edu	37	6	31084214	31084214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31084214G>A	ENST00000376288.2	-	2	1204	c.1178C>T	c.(1177-1179)cCc>cTc	p.P393L	PSORS1C1_ENST00000259881.9_Intron|PSORS1C1_ENST00000467107.1_3'UTR	NM_001264.4	NP_001255.3	Q15517	CDSN_HUMAN	corneodesmosin	393	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)	10						AGAACTGGAGGGAGAGCAGGG	0.642000													7	7					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152278088	152278088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152278088C>T	ENST00000368799.1	-	3	9309	c.9274G>A	c.(9274-9276)Gag>Aag	p.E3092K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3092	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGCCTGCTCATGGCGGGAT	0.577000									Ichthyosis				97	263					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117251691	117251691	+	Missense_Mutation	SNP	C	C	T	rs78194216		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117251691C>T	ENST00000003084.6	+	20	3328	c.3196C>T	c.(3196-3198)Cgt>Tgt	p.R1066C	AC000111.6_ENST00000456270.1_RNA|CFTR_ENST00000454343.1_Missense_Mutation_p.R1005C	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1066	ABC transmembrane type-1 2.		R -> C (in CF).|R -> H (in CF).|R -> L (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ATGGACACTTCGTGCCTTCGG	0.413000									Cystic Fibrosis				15	34					0	0	1	0	0
TTC12	54970	broad.mit.edu	37	11	113233182	113233182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113233182C>T	ENST00000393020.1	+	19	2079	c.1674C>T	c.(1672-1674)gcC>gcT	p.A558A	TTC12_ENST00000483239.2_Silent_p.A564A|TTC12_ENST00000529221.1_Silent_p.A558A|TTC12_ENST00000314756.3_Silent_p.A558A			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	558							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TTGAGGAGGCCTTGCGAGCAG	0.418000													33	70					0	0	1	0	0
MIR563	693148	broad.mit.edu	37	3	15915346	15915346	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:15915346C>T	ENST00000385080.1	+	0	69					NR_030289.1																						CATACGTTTCCCTGGTAGCCA	0.383000													36	73					0	0	1	0	0
C11orf65	160140	broad.mit.edu	37	11	108256663	108256663	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108256663A>G	ENST00000525729.1	-	6	693	c.624T>C	c.(622-624)tcT>tcC	p.S208S	C11orf65_ENST00000393084.1_Silent_p.S257S|C11orf65_ENST00000529391.1_Silent_p.S257S|C11orf65_ENST00000526725.1_Intron			Q8NCR3	CK065_HUMAN	chromosome 11 open reading frame 65	257										endometrium(1)|large_intestine(3)|lung(4)|ovary(2)	10		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		AGTTAGCCGAAGAGTTGCTTG	0.333000													17	219					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793298	29793298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29793298C>T	ENST00000269202.6	+	11	1402	c.1355C>T	c.(1354-1356)cCa>cTa	p.P452L	MEP1B_ENST00000581447.1_Missense_Mutation_p.P452L	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	452	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TATAGCCCTCCATTTTACTCT	0.408000													4	31					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21469372	21469372	+	Nonsense_Mutation	SNP	C	C	T	rs1042848		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21469372C>T	ENST00000222584.3	+	3	807	c.589C>T	c.(589-591)Cag>Tag	p.Q197*		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	197			Q -> K (in dbSNP:rs1042848).		regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						GGGTCAAATTCAGCTCATTTC	0.408000													39	89					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73161477	73161477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73161477G>A	ENST00000286657.4	-	19	2653	c.2617C>T	c.(2617-2619)Cgt>Tgt	p.R873C		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	873	TSP type-1 2.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTTTTCCTACGGCATCCATAT	0.368000													28	89					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112777075	112777075	+	Missense_Mutation	SNP	G	G	A	rs147779020	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:112777075G>A	ENST00000295408.4	+	16	2422	c.2165G>A	c.(2164-2166)cGa>cAa	p.R722Q	MERTK_ENST00000409780.1_Missense_Mutation_p.R546Q|MERTK_ENST00000421804.2_Missense_Mutation_p.R722Q			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	722	Protein kinase.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TTTCTTCATCGAGATTTAGCT	0.463000													52	91					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164320	139164320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139164320C>T	ENST00000395297.1	-	13	2568	c.2398G>A	c.(2398-2400)Gat>Aat	p.D800N		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	800										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGTGCATATCTGAAGGTTCA	0.522000										HNSCC(54;0.14)			7	48					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767335	105767335	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:105767335C>T	ENST00000374798.3	+	5	492	c.422C>T	c.(421-423)tCa>tTa	p.S141L	CYLC2_ENST00000487798.1_Missense_Mutation_p.S141L	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	141	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				aaaaaagattcaaagaaaggc	0.353000													8	31					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2297770	2297770	+	Silent	SNP	C	C	T	rs139192773		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2297770C>T	ENST00000381458.5	+	6	789	c.726C>T	c.(724-726)acC>acT	p.T242T	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	242					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	GCACTTACACCGGTGGCCGGG	0.537000													35	112					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857389	9857389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9857389C>T	ENST00000396573.2	-	14	4321	c.4012G>A	c.(4012-4014)Ggg>Agg	p.G1338R	GRIN2A_ENST00000535259.1_Intron|GRIN2A_ENST00000404927.2_Intron|GRIN2A_ENST00000562109.1_Intron|GRIN2A_ENST00000330684.3_Missense_Mutation_p.G1338R|GRIN2A_ENST00000396575.2_Missense_Mutation_p.G1338R	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1338					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTTTTTTTCCCCGAGAGTTTG	0.547000													17	83					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101350846	101350846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101350846C>T	ENST00000534062.1	-	1	338	c.280G>A	c.(280-282)Gac>Aac	p.D94N	MIR432_ENST00000606207.1_RNA	NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	94										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TGGAGTAGGTCATTGGGTGGA	0.532000													40	56					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74536357	74536357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74536357C>T	ENST00000321288.5	+	4	662	c.662C>T	c.(661-663)gCc>gTc	p.A221V	CCDC33_ENST00000398814.3_Missense_Mutation_p.A18V			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	221							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CCCCTGATCGCCTCCCAGAGC	0.557000													34	159					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95422344	95422344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95422344G>A	ENST00000371447.3	+	20	2449	c.2311G>A	c.(2311-2313)Gaa>Aaa	p.E771K	PDE6C_ENST00000475427.2_3'UTR	NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	771					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				CAAAAGAGATGAATTACCTAA	0.279000													15	57					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46827113	46827113	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46827113G>A	ENST00000283296.7	-	17	2815	c.2527C>T	c.(2527-2529)Cct>Tct	p.P843S	GPR116_ENST00000456426.2_Missense_Mutation_p.P701S|GPR116_ENST00000265417.7_Missense_Mutation_p.P843S|GPR116_ENST00000545669.1_Missense_Mutation_p.P272S|GPR116_ENST00000362015.4_Missense_Mutation_p.P843S	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	843					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			AAGGACAAAGGAGGGCTATCT	0.448000													20	40					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155232579	155232579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155232579G>A	ENST00000460012.1	-	12	1832	c.1475C>T	c.(1474-1476)cCt>cTt	p.P492L	PLCH1_ENST00000414191.1_Missense_Mutation_p.P492L|PLCH1_ENST00000340059.7_Missense_Mutation_p.P510L|PLCH1_ENST00000334686.6_Missense_Mutation_p.P492L|PLCH1_ENST00000447496.2_Missense_Mutation_p.P510L|PLCH1_ENST00000494598.1_Missense_Mutation_p.P510L			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	510					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GAAACTATCAGGATCTTCTTT	0.428000													13	46					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987554	61987554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61987554C>T	ENST00000450719.3	-	3	394	c.157G>A	c.(157-159)Gac>Aac	p.D53N	CSHL1_ENST00000438387.2_Missense_Mutation_p.D64N|CSHL1_ENST00000346606.6_Missense_Mutation_p.D53N|CSHL1_ENST00000309894.5_Missense_Mutation_p.D147N|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000561003.1_Missense_Mutation_p.D64N|CSHL1_ENST00000259003.10_Missense_Mutation_p.D85N|CSHL1_ENST00000558099.1_5'UTR			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	147						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						TCCTCTAGGTCCTTTAGGAGG	0.592000													7	79					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106841174	106841174	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:106841174C>T	ENST00000276185.4	+	15	2164	c.2164C>T	c.(2164-2166)Cag>Tag	p.Q722*				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	722						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						CCGGGCTGTCCAGAGCCAGGA	0.567000													35	14					0	0	1	0	0
PDXDC1	23042	broad.mit.edu	37	16	15122865	15122865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15122865C>T	ENST00000455313.2	+	14	1386	c.1266C>T	c.(1264-1266)gtC>gtT	p.V422V	PDXDC1_ENST00000569715.1_Intron|PDXDC1_ENST00000535621.2_Intron|PDXDC1_ENST00000396410.4_Intron|PDXDC1_ENST00000325823.7_Intron|PDXDC1_ENST00000450288.2_Intron|PDXDC1_ENST00000563679.1_Intron|PDXDC1_ENST00000447912.2_Intron			Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain containing 1	0					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	AGGTCCCCGTCCATCACCATC	0.637000													6	25					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130319507	130319507	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130319507C>T	ENST00000299164.2	+	1	639	c.639C>T	c.(637-639)ttC>ttT	p.F213F		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	213					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCAAGCGTTTCGTGTCTATCC	0.667000													7	6					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44673674	44673674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44673674C>T	ENST00000454036.1	+	12	1609	c.1533C>T	c.(1531-1533)gtC>gtT	p.V511V	SLC12A5_ENST00000243964.3_Silent_p.V488V|SLC12A5_ENST00000539566.1_Intron	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	511					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GGGTAATTGTCATCGGATCCT	0.612000													48	176					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149356757	149356757	+	Missense_Mutation	SNP	G	G	A	rs72645628	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:149356757G>A	ENST00000355292.3	-	2	1618	c.1256C>T	c.(1255-1257)tCg>tTg	p.S419L	NR3C2_ENST00000344721.4_Missense_Mutation_p.S419L|NR3C2_ENST00000342437.4_Missense_Mutation_p.S419L|NR3C2_ENST00000511528.1_Missense_Mutation_p.S419L|NR3C2_ENST00000512865.1_Missense_Mutation_p.S419L|NR3C2_ENST00000358102.3_Missense_Mutation_p.S419L			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	419	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TGAAGAATCCGAATTTATTTT	0.393000													24	107					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713517	142713517	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:142713517C>T	ENST00000369381.2	-	0	1088																											TTCACACTTTCACTGTGTTTA	0.368000													11	73					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44639787	44639787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44639787C>T	ENST00000372330.3	+	5	674	c.655C>T	c.(655-657)Cca>Tca	p.P219S		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	219					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TGCAGTGGTTCCAACTCGGTT	0.632000													115	281					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51380010	51380010	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51380010G>A	ENST00000325321.3	+	3	714	c.489G>A	c.(487-489)gaG>gaA	p.E163E	KLK2_ENST00000391810.2_Silent_p.E61E|KLK2_ENST00000358049.4_Silent_p.E163E			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	163	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		TCGAACCAGAGGAGTGTACGC	0.642000			T	ETV4	prostate								11	34					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128990073	128990073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128990073G>A	ENST00000274487.4	+	14	2378	c.2233G>A	c.(2233-2235)Gga>Aga	p.G745R	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	745	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G745R(1)		NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AGTGATGGATGGAACTTCTTG	0.353000													13	95					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10079083	10079083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10079083G>A	ENST00000264828.3	-	59	4377	c.4292C>T	c.(4291-4293)cCc>cTc	p.P1431L		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1431	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGGACCAGGGGGTCCCTGCAC	0.597000													72	172					0	0	1	0	0
RPL18	6141	broad.mit.edu	37	19	49120585	49120585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49120585G>A	ENST00000549273.1	-	3	219	c.186C>T	c.(184-186)tcC>tcT	p.S62S	RPL18_ENST00000549920.1_Silent_p.S62S|RPL18_ENST00000552588.1_Silent_p.S33S|RPL18_ENST00000550645.1_Silent_p.S62S			Q07020	RL18_HUMAN	ribosomal protein L18	62				S -> C (in Ref. 3; AAH21743).	endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			cervix(1)|kidney(2)	3		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)		TCCGGGAAAGGGACAGAGGCG	0.562000													56	167					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137623485	137623485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137623485G>A	ENST00000371817.3	+	8	1722	c.1308G>A	c.(1306-1308)gcG>gcA	p.A436A		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	436	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding	p.A436A(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GAATGCCGGCGAACCAGGATA	0.637000													14	97					0	0	1	0	0
IGKV5-2	28907	broad.mit.edu	37	2	89197096	89197096	+	RNA	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89197096A>G	ENST00000390244.2	+	0	204																											AAGCCAGCCAAGACATTGATG	0.463000													7	107					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55216156	55216156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55216156G>A	ENST00000340465.2	+	5	562	c.476G>A	c.(475-477)gGa>gAa	p.G159E		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	159						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TCAGCAAATGGAAATCCGTGT	0.453000													74	213					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119943026	119943026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119943026G>A	ENST00000327554.2	+	7	1266	c.801G>A	c.(799-801)gtG>gtA	p.V267V	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	267										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCCCAAGTGTGAACACCCAGG	0.552000													56	199					0	0	1	0	0
DYNLRB2	83657	broad.mit.edu	37	16	80583494	80583494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:80583494G>A	ENST00000305904.6	+	3	313	c.193G>A	c.(193-195)Gac>Aac	p.D65N	DYNLRB2_ENST00000568035.1_Intron|RP11-109P11.1_ENST00000568275.1_RNA|DYNLRB2_ENST00000562982.1_Missense_Mutation_p.D94N|DYNLRB2_ENST00000570222.1_3'UTR|RP11-525K10.3_ENST00000568776.1_RNA	NM_130897.1	NP_570967.1	Q8TF09	DLRB2_HUMAN	dynein, light chain, roadblock-type 2	65					microtubule-based movement|transport	cytoplasmic dynein complex|microtubule	microtubule motor activity			large_intestine(1)|lung(4)|prostate(1)	6						TCCTCAGAACGACCTGACTTT	0.383000													20	51					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3834911	3834911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3834911C>T	ENST00000262961.4	-	2	134	c.124G>A	c.(124-126)Gac>Aac	p.D42N	ZFR2_ENST00000591965.1_5'UTR	NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	42						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		ACGGCAGGGTCCATCCCAGGA	0.667000													6	9					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124268560	124268560	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124268560G>A	ENST00000409039.3	+	8	908	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	295	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGCGCTGCATGAACAAACAAA	0.443000													23	52					0	0	1	0	0
HMP19	51617	broad.mit.edu	37	5	173473792	173473792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:173473792G>A	ENST00000303177.3	+	2	296	c.34G>A	c.(34-36)Gga>Aga	p.G12R	NSG2_ENST00000521585.1_Missense_Mutation_p.G12R	NM_015980.4	NP_057064.1																					CAGCGAGAAGGGAACCAAGCC	0.532000													39	103					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15996760	15996760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15996760C>T	ENST00000221700.5	-	9	1184	c.1089G>A	c.(1087-1089)aaG>aaA	p.K363K	CYP4F2_ENST00000592328.1_Silent_p.K363K|CYP4F2_ENST00000011989.7_3'UTR	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	363					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GCTCACGGTCCTTCAGAAGTT	0.577000													32	79					0	0	1	0	0
FFAR2	2867	broad.mit.edu	37	19	35940700	35940700	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35940700C>T	ENST00000599180.1	+	2	164	c.84C>T	c.(82-84)gcC>gcT	p.A28A	FFAR2_ENST00000246549.2_Silent_p.A28A|FFAR2_ENST00000601590.1_Intron			O15552	FFAR2_HUMAN	free fatty acid receptor 2	28						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			ACCTCCTGGCCCTGCGGGCCT	0.632000													14	79					0	0	1	0	0
ZBTB32	27033	broad.mit.edu	37	19	36207515	36207515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36207515C>T	ENST00000392197.2	+	7	1643	c.1325C>T	c.(1324-1326)tCc>tTc	p.S442F	ZBTB32_ENST00000262630.3_Missense_Mutation_p.S442F			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	442					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGCCTGGCCTCCATGCAGGCG	0.711000											OREG0025433	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	69					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71871187	71871187	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71871187C>T	ENST00000258104.3	+	41	4780	c.4503C>T	c.(4501-4503)acC>acT	p.T1501T	DYSF_ENST00000410041.1_Silent_p.T1519T|DYSF_ENST00000429174.2_Silent_p.T1522T|DYSF_ENST00000409744.1_Silent_p.T1509T|DYSF_ENST00000410020.3_Silent_p.T1540T|DYSF_ENST00000394120.2_Silent_p.T1502T|DYSF_ENST00000409366.1_Silent_p.T1523T|DYSF_ENST00000409582.3_Silent_p.T1539T|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Silent_p.T1532T|DYSF_ENST00000409651.1_Silent_p.T1533T|DYSF_ENST00000409762.1_Silent_p.T1518T	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1501						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATTTTGACACCCTGAAGGTAA	0.507000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575593	179575593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179575593C>T	ENST00000589042.1	-	98	28455	c.28231G>A	c.(28231-28233)Gga>Aga	p.G9411R	TTN_ENST00000342992.6_Missense_Mutation_p.G8167R|TTN_ENST00000591111.1_Missense_Mutation_p.G9094R|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9094	Ig-like 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACTTTCTCCCACCACAGCA	0.512000													16	63					0	0	1	0	0
SYPL2	284612	broad.mit.edu	37	1	110019517	110019517	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110019517C>T	ENST00000369872.3	+	4	590	c.374C>T	c.(373-375)tCc>tTc	p.S125F	SYPL2_ENST00000401021.3_Missense_Mutation_p.S125F	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	125	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGCATCTTTTCCTTCTTCTAT	0.552000													28	61					0	0	1	0	0
PODXL	5420	broad.mit.edu	37	7	131195771	131195771	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131195771C>T	ENST00000541194.1	-	2	785	c.528G>A	c.(526-528)aaG>aaA	p.K176K	PODXL_ENST00000322985.9_Silent_p.K174K|PODXL_ENST00000537928.1_Silent_p.K174K|PODXL_ENST00000378555.3_Silent_p.K174K	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	174	Thr-rich.				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					GATGTTCTGCCTTAGTGGATG	0.547000													46	189					0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19378100	19378100	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:19378100G>T	ENST00000550708.1	+	1	579	c.507G>T	c.(505-507)ctG>ctT	p.L169L		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGATTTCTGTGGTTCCTGA	0.488000													28	146					8.73648e-17	8.78404e-17	1	1	0
PROSER1	80209	broad.mit.edu	37	13	39597240	39597240	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39597240G>A	ENST00000352251.3	-	8	1425	c.592C>T	c.(592-594)Cct>Tct	p.P198S	PROSER1_ENST00000350125.3_Missense_Mutation_p.P176S|PROSER1_ENST00000484434.2_Intron	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	198	Pro-rich.																TAAGGAACAGGTTTATGTGGA	0.378000													16	136					0	0	1	0	0
KLHL5	51088	broad.mit.edu	37	4	39083717	39083717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39083717C>T	ENST00000261425.3	+	5	990	c.838C>T	c.(838-840)Cgt>Tgt	p.R280C	KLHL5_ENST00000359687.2_Missense_Mutation_p.R326C|KLHL5_ENST00000381930.3_Missense_Mutation_p.R326C|KLHL5_ENST00000508137.2_Missense_Mutation_p.R139C|KLHL5_ENST00000504108.1_Missense_Mutation_p.R326C|KLHL5_ENST00000261426.5_Missense_Mutation_p.R265C	NM_001007075.2	NP_001007076.1	Q96PQ7	KLHL5_HUMAN	kelch-like family member 5	326	BTB.					cytoplasm|cytoskeleton	actin binding	p.R326C(3)|p.R326G(1)		endometrium(3)|kidney(1)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29						TCTTGGAATTCGTTCTTTTGC	0.393000													72	221					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46727878	46727878	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46727878G>A	ENST00000318962.4	-	6	669	c.586C>T	c.(586-588)Ctg>Ttg	p.L196L	ALS2CL_ENST00000415953.1_Silent_p.L196L	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	196					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AAGGACTGCAGGTTCCCAAAG	0.617000													20	55					0	0	1	0	0
HPD	3242	broad.mit.edu	37	12	122292683	122292683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122292683C>T	ENST00000543163.1	-	8	668	c.223G>A	c.(223-225)Ggc>Agc	p.G75S	HPD_ENST00000289004.4_Missense_Mutation_p.G114S	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	114					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	ATTTTGGCGCCCCGTTCCCGT	0.602000													15	112					0	0	1	0	0
TRPV3	162514	broad.mit.edu	37	17	3458126	3458126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3458126C>T	ENST00000301365.4	-	2	150	c.19G>A	c.(19-21)Gag>Aag	p.E7K	TRPV3_ENST00000572519.1_Missense_Mutation_p.E7K|TRPV3_ENST00000576742.1_Missense_Mutation_p.E7K			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	7						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	GGCACCATCTCCTTGGGGTGG	0.622000													13	24					0	0	1	0	0
IGHG4	3503	broad.mit.edu	37	14	106091705	106091705	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106091705C>T	ENST00000390543.2	-	0	306																											CATGGGGGACCATATTTGGAC	0.592000													60	140					0	0	1	0	0
GATM	2628	broad.mit.edu	37	15	45669010	45669010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45669010C>T	ENST00000396659.3	-	2	416	c.77G>A	c.(76-78)cGa>cAa	p.R26Q	GATM_ENST00000558336.1_Missense_Mutation_p.R26Q	NM_001482.2	NP_001473.1	P50440	GATM_HUMAN	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	26					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	15		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	TGTCAAGGTTCGTCCAAGCTT	0.488000													6	21					0	0	1	0	0
DSCR4	10281	broad.mit.edu	37	21	39492501	39492501	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39492501C>T	ENST00000328264.3	-	2	234	c.128_splice	c.e2-1	p.E44_splice	DSCR4_ENST00000398948.1_Splice_Site_p.E44_splice	NM_005867.2	NP_005858.1	P56555	DSCR4_HUMAN	Down syndrome critical region gene 4	44										large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	6						attttttcttctctaggaaaa	0.413000													24	44					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38591833	38591833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38591833C>T	ENST00000413689.1	-	28	6223	c.6030G>A	c.(6028-6030)agG>agA	p.R2010R	SCN5A_ENST00000423572.2_Silent_p.R2009R|SCN5A_ENST00000425664.1_Silent_p.R1992R|SCN5A_ENST00000333535.4_Silent_p.R2010R|SCN5A_ENST00000451551.2_Silent_p.R1956R|SCN5A_ENST00000455624.2_Silent_p.R1977R|SCN5A_ENST00000449557.2_Silent_p.R1956R|SCN5A_ENST00000450102.2_Silent_p.R1956R|SCN5A_ENST00000443581.1_Silent_p.R2009R|SCN5A_ENST00000414099.2_Silent_p.R1992R	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	2010					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACTCACGGTCCCTGTCCGGAG	0.567000													39	88					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47561043	47561043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47561043G>A	ENST00000273859.3	+	13	2807	c.2538G>A	c.(2536-2538)aaG>aaA	p.K846K	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	846					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GTATAGCAAAGAAGGTGAGAC	0.428000													17	86					0	0	1	0	0
OR2T8	343172	broad.mit.edu	37	1	248084349	248084349	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248084349C>T	ENST00000319968.4	+	1	30	c.30C>T	c.(28-30)ttC>ttT	p.F10F		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCTCTTATTTCATTCTCCTAG	0.413000													31	84					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71003055	71003055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71003055G>A	ENST00000334414.6	-	4	817	c.773C>T	c.(772-774)tCt>tTt	p.S258F	PTPRB_ENST00000550358.1_Missense_Mutation_p.S258F|PTPRB_ENST00000551525.1_Missense_Mutation_p.S257F|PTPRB_ENST00000261266.5_Missense_Mutation_p.S40F|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000451516.2_Missense_Mutation_p.S40F|PTPRB_ENST00000538708.1_Missense_Mutation_p.S40F|PTPRB_ENST00000550857.1_Missense_Mutation_p.S40F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	40	Fibronectin type-III 3.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GATAGACACAGAATGGCTGGA	0.527000													12	47					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130855747	130855747	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130855747C>T	ENST00000245255.3	+	20	2620	c.2348C>T	c.(2347-2349)gCt>gTt	p.A783V	PIWIL1_ENST00000541480.1_3'UTR	NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	783	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GTGAGCCAGGCTGTGAGAAGT	0.443000													63	112					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27206694	27206694	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27206694C>T	ENST00000380036.4	+	15	2921	c.2479C>T	c.(2479-2481)Caa>Taa	p.Q827*	TEK_ENST00000519097.1_Nonsense_Mutation_p.Q679*|TEK_ENST00000406359.4_Nonsense_Mutation_p.Q784*	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	827	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CATCAAATTTCAAGATGTGAT	0.453000													9	45					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627428	43627428	+	Missense_Mutation	SNP	G	G	A	rs11261835	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:43627428G>A	ENST00000332857.6	-	4	1287	c.1259C>T	c.(1258-1260)cCc>cTc	p.P420L		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6									p.P420L(1)									GTGCAGAGAGGGGAGGCCCCA	0.498000													10	183					0	0	1	0	0
C3orf67	200844	broad.mit.edu	37	3	58855057	58855057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58855057G>A	ENST00000472469.1	-	8	1235	c.397C>T	c.(397-399)Cat>Tat	p.H133Y	RP11-147N17.1_ENST00000482372.1_RNA|C3orf67_ENST00000295966.7_Missense_Mutation_p.H213Y|RP11-147N17.1_ENST00000492031.1_RNA|RP11-147N17.1_ENST00000463703.1_RNA|C3orf67_ENST00000482387.1_Missense_Mutation_p.H213Y|RP11-147N17.1_ENST00000493123.1_RNA			Q6ZVT6	CC067_HUMAN	chromosome 3 open reading frame 67	213										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		TTCTTACCATGAATAGGTACA	0.328000													17	70					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51205785	51205785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51205785C>T	ENST00000293441.1	-	11	1704	c.1686G>A	c.(1684-1686)gtG>gtA	p.V562V	SHANK1_ENST00000359082.3_Silent_p.V562V|SHANK1_ENST00000391814.1_Silent_p.V562V	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	562	SH3.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGTAGGACTTCACAGCCATGA	0.697000													3	23					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136536720	136536720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136536720C>T	ENST00000371872.4	-	18	2520	c.2263G>A	c.(2263-2265)Ggt>Agt	p.G755S	SARDH_ENST00000371868.1_Missense_Mutation_p.G183S|SARDH_ENST00000422262.2_Missense_Mutation_p.G587S|SARDH_ENST00000439388.1_Missense_Mutation_p.G755S	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	755					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGCTTGGCACCCGCGGCCATC	0.667000													4	14					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	57002771	57002771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57002771G>A	ENST00000371250.3	-	2	704	c.153C>T	c.(151-153)ttC>ttT	p.F51F		NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	51					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						CGATGATGAGGAAGGGGAGGC	0.458000													20	74					0	0	1	0	0
CADM4	199731	broad.mit.edu	37	19	44127496	44127496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44127496C>T	ENST00000222374.2	-	9	1201	c.1153G>A	c.(1153-1155)Gaa>Aaa	p.E385K		NM_145296.1	NP_660339.1	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4	385					cell adhesion	integral to membrane				endometrium(2)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	12		Prostate(69;0.0199)				ATGAAGAATTCCTCTTTCCTC	0.577000													44	105					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92606763	92606763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92606763C>T	ENST00000342818.3	+	7	1161	c.925C>T	c.(925-927)Cag>Tag	p.Q309*	BTBD8_ENST00000540648.1_Intron	NM_183242.3	NP_899065.2	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	309						nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		TAATTTCTTTCAGAAGGTAAT	0.299000													26	56					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100330033	100330033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100330033C>T	ENST00000294724.4	+	5	1030	c.552C>T	c.(550-552)gaC>gaT	p.D184D	AGL_ENST00000370163.3_Silent_p.D184D|AGL_ENST00000370161.2_Silent_p.D168D|AGL_ENST00000361302.3_Silent_p.D168D|AGL_ENST00000361522.4_Silent_p.D167D|AGL_ENST00000361915.3_Silent_p.D184D|AGL_ENST00000370165.3_Silent_p.D184D	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	184					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TAAATCCTGACTTTTCAAGAC	0.368000													28	115					0	0	1	0	0
DCLK2	166614	broad.mit.edu	37	4	151153862	151153862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:151153862C>T	ENST00000296550.7	+	10	2202	c.1448C>T	c.(1447-1449)tCg>tTg	p.S483L	DCLK2_ENST00000302176.8_Missense_Mutation_p.S500L|DCLK2_ENST00000506325.1_Missense_Mutation_p.S482L	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	483	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity	p.S500L(1)|p.S483L(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					GCAATTACTTCGTCGACCAAG	0.448000													45	210					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49166090	49166090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49166090G>A	ENST00000307885.4	-	17	3469	c.2775C>T	c.(2773-2775)ctC>ctT	p.L925L	ADCY6_ENST00000357869.3_Silent_p.L872L|ADCY6_ENST00000550422.1_Silent_p.L872L	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	925					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GTAGTTTCCAGAGGAAGTCTA	0.567000													12	79					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48391896	48391896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48391896G>A	ENST00000435803.1	+	31	10524	c.10500G>A	c.(10498-10500)gtG>gtA	p.V3500V		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3500					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GAACAGATGTGGTAAAAAACC	0.453000													31	61					0	0	1	0	0
BGN	633	broad.mit.edu	37	X	152770723	152770723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:152770723C>T	ENST00000331595.4	+	3	452	c.266C>T	c.(265-267)tCc>tTc	p.S89F	BGN_ENST00000480756.1_3'UTR|BGN_ENST00000370204.1_Missense_Mutation_p.S28F	NM_001711.4	NP_001702.1	P21810	PGS1_HUMAN	biglycan	89						proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AAAGAGATCTCCCCTGACACC	0.597000													34	27					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156727807	156727807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156727807C>T	ENST00000347377.6	+	6	903	c.472C>T	c.(472-474)Ctc>Ttc	p.L158F	CYFIP2_ENST00000377576.3_Missense_Mutation_p.L158F|CYFIP2_ENST00000318218.6_Missense_Mutation_p.L158F|CYFIP2_ENST00000541131.1_Missense_Mutation_p.L83F|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000521420.1_Missense_Mutation_p.L132F|CYFIP2_ENST00000442283.2_5'UTR	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	158					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGAGGCCTACCTCCTGACCCT	0.572000													13	26					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169985	113169985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113169985C>T	ENST00000401783.2	-	38	8231	c.7895G>A	c.(7894-7896)gGa>gAa	p.G2632E	SVEP1_ENST00000374469.1_Missense_Mutation_p.G2609E|SVEP1_ENST00000297826.5_Missense_Mutation_p.G558E	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2632					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTCAAAATATCCCTGGTCATC	0.438000													53	213					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63700140	63700140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:63700140G>A	ENST00000279873.7	+	3	885	c.475G>A	c.(475-477)Gac>Aac	p.D159N		NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	159					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CAACTTCAAAGACGTTCTCAA	0.438000													5	26					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1217051	1217051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1217051C>T	ENST00000304460.10	+	8	1220	c.1164C>T	c.(1162-1164)ttC>ttT	p.F388F		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	388					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCAACGCCTTCCTCTCAGAGG	0.662000													41	86					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57293412	57293412	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57293412G>A	ENST00000391708.3	-	10	1097	c.555C>T	c.(553-555)ttC>ttT	p.F185F	ZIM2_ENST00000221722.5_Silent_p.F185F|ZIM2_ENST00000601070.1_Silent_p.F185F|ZIM2_ENST00000599935.1_Silent_p.F185F|AC006115.3_ENST00000597946.1_RNA|ZIM2_ENST00000593711.1_Silent_p.F185F|AC006115.3_ENST00000594400.1_RNA|AC006115.3_ENST00000595954.1_RNA	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		CCTCTGGGCTGAAGTCCACAA	0.507000													51	119					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21755884	21755884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:21755884G>A	ENST00000382254.1	-	14	2787	c.1701C>T	c.(1699-1701)ctC>ctT	p.L567L	CDH12_ENST00000521384.1_5'UTR|RP11-804N13.1_ENST00000522350.1_RNA|CDH12_ENST00000504376.2_Silent_p.L567L|CDH12_ENST00000522262.1_Silent_p.L527L	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	567	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TTACAACAGGGAGGAAATACA	0.453000										HNSCC(59;0.17)			33	22					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751993	140751993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140751993C>T	ENST00000576222.1	+	1	2163	c.2032C>T	c.(2032-2034)Cgc>Tgc	p.R678C	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTAGCGACCGCCCCACTCC	0.557000													24	97					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436749	248436749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248436749G>A	ENST00000318021.2	-	1	389	c.368C>T	c.(367-369)gCt>gTt	p.A123V		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTGGCAGACAGCCGCATAGCG	0.607000													21	111					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26676281	26676281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26676281G>A	ENST00000288710.2	+	14	1857	c.1783G>A	c.(1783-1785)Gag>Aag	p.E595K		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		gacggagatggagggagaaaa	0.572000													26	68					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542206	133542206	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133542206T>A	ENST00000409261.1	-	14	2551	c.2178A>T	c.(2176-2178)gcA>gcT	p.A726A	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Silent_p.A726A	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	726							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TATAGTCTCTTGCAGCAGCTC	0.408000													7	89					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48936095	48936095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48936095C>T	ENST00000294954.7	-	8	693	c.672G>A	c.(670-672)ccG>ccA	p.P224P	LHCGR_ENST00000405626.1_Silent_p.P224P|LHCGR_ENST00000403273.1_Silent_p.P224P|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000344775.3_Silent_p.P224P|LHCGR_ENST00000401907.1_Silent_p.P224P	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	224					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	ACAAGGTTTTCGGCCCTGTGG	0.547000													48	121					0	0	1	0	0
SPATA31D4	389761	broad.mit.edu	37	9	84549011	84549011	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84549011G>A	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							CAAAGAGAGTGAGCCCTTTAA	0.507000													4	9					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644414	169644414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169644414C>T	ENST00000428432.2	+	6	753	c.364C>T	c.(364-366)Cta>Tta	p.L122L	SAMD7_ENST00000335556.3_Silent_p.L122L	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	122										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			ACTAGCAGGCCTAGGGATACC	0.468000													35	68					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152325151	152325151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152325151C>T	ENST00000388718.5	-	3	5183	c.5111G>A	c.(5110-5112)aGa>aAa	p.R1704K	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1704							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGGGCATGTCTAGTGGTATC	0.493000													116	389					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69376695	69376695	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:69376695G>A	ENST00000193403.6	-	5	875	c.492C>T	c.(490-492)gtC>gtT	p.V164V	ACTN1_ENST00000538545.2_Silent_p.V164V|ACTN1_ENST00000376839.3_Silent_p.V99V|ACTN1_ENST00000554508.1_5'UTR|ACTN1_ENST00000438964.2_Silent_p.V164V|ACTN1_ENST00000394419.4_Silent_p.V164V	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	164	Actin-binding.|CH 2.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TCTGGATGTTGACATTTTTGT	0.592000													30	71					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774646	140774646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140774646G>A	ENST00000398604.2	+	1	2266	c.2266G>A	c.(2266-2268)Gaa>Aaa	p.E756K	PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATTCCCAGGAAGTCTCCCT	0.562000													13	110					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77762534	77762534	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77762534C>T	ENST00000521891.2	+	9	4348	c.3900C>T	c.(3898-3900)gcC>gcT	p.A1300A	ZFHX4_ENST00000455469.2_Silent_p.A1255A|ZFHX4_ENST00000050961.6_Silent_p.A1255A|ZFHX4_ENST00000518282.1_Silent_p.A1274A	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1255						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGCAGCTGCCTCTGAGAAAT	0.478000										HNSCC(33;0.089)			10	14					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24170931	24170931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24170931C>T	ENST00000265769.4	+	6	524	c.414C>T	c.(412-414)taC>taT	p.Y138Y	ADAM28_ENST00000437154.2_Silent_p.Y138Y|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_Intron|RP11-624C23.1_ENST00000523578.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	138					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATCAAAGATACTTTATTGAAC	0.403000													13	58					0	0	1	0	0
CSN1S1	1446	broad.mit.edu	37	4	70810661	70810661	+	Missense_Mutation	SNP	G	G	A	rs149927680	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70810661G>A	ENST00000246891.4	+	15	545	c.496G>A	c.(496-498)Gac>Aac	p.D166N	CSN1S1_ENST00000444405.3_Missense_Mutation_p.D157N|CSN1S1_ENST00000507772.1_Missense_Mutation_p.D158N|CSN1S1_ENST00000505782.1_Missense_Mutation_p.D150N|CSN1S1_ENST00000507763.1_Missense_Mutation_p.D157N	NM_001890.1	NP_001881.1	P47710	CASA1_HUMAN	casein alpha s1	166						extracellular region	protein binding|transporter activity			lung(5)|prostate(1)|upper_aerodigestive_tract(1)	7						ACCGTTTTCCGACATCTCCAA	0.418000													15	224					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76232504	76232504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76232504C>T	ENST00000298832.9	+	20	2013	c.1808C>T	c.(1807-1809)tCc>tTc	p.S603F	TTLL5_ENST00000554510.1_Missense_Mutation_p.S112F|TTLL5_ENST00000555422.1_3'UTR|TTLL5_ENST00000556893.1_Missense_Mutation_p.S154F|TTLL5_ENST00000557636.1_Missense_Mutation_p.S617F	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	603					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		CAGGAGGCTTCCCAGGAGGAG	0.403000													20	39					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96076520	96076520	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:96076520C>T	ENST00000343702.4	-	7	1921	c.1473G>A	c.(1471-1473)tgG>tgA	p.W491*	NTN4_ENST00000344911.4_Nonsense_Mutation_p.W454*|NTN4_ENST00000553059.1_Nonsense_Mutation_p.W491*|NTN4_ENST00000538383.1_Nonsense_Mutation_p.W454*	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	491					axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						GCGCATCCTCCCACTCCCAGG	0.463000													14	55					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21470000	21470000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21470000C>T	ENST00000313654.9	+	42	5570	c.5329C>T	c.(5329-5331)Ccc>Tcc	p.P1777S	LAMA3_ENST00000587184.1_Missense_Mutation_p.P168S|LAMA3_ENST00000399516.3_Missense_Mutation_p.P1777S|LAMA3_ENST00000269217.6_Missense_Mutation_p.P168S	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1777	Domain III A.|Laminin EGF-like 14.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTCGGGAATCCCCAGAAATT	0.493000													35	120					0	0	1	0	0
ZNF837	116412	broad.mit.edu	37	19	58879844	58879844	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58879844G>A	ENST00000427624.2	-	3	1178	c.856C>T	c.(856-858)Ctg>Ttg	p.L286L	ZNF837_ENST00000597582.1_Silent_p.L286L			Q96EG3	ZN837_HUMAN	zinc finger protein 837	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|skin(1)	2						TGCTGCAGCAGGCTGGAGGTG	0.701000													4	7					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132047130	132047130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:132047130G>A	ENST00000336375.5	+	2	230	c.140G>A	c.(139-141)cGa>cAa	p.R47Q	ACPP_ENST00000475741.1_Missense_Mutation_p.R47Q|ACPP_ENST00000351273.7_Missense_Mutation_p.R47Q|ACPP_ENST00000489084.1_3'UTR	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	47						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						CATGGAGACCGAAGTCCCATT	0.433000													20	52					0	0	1	0	0
GATA6	2627	broad.mit.edu	37	18	19751212	19751212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:19751212C>T	ENST00000269216.3	+	2	384	c.107C>T	c.(106-108)cCt>cTt	p.P36L	GATA6_ENST00000581694.1_Missense_Mutation_p.P36L	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	36					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			TCCACGCCGCCTTCCCCCATC	0.736000													15	23					0	0	1	0	0
METTL24	728464	broad.mit.edu	37	6	110620340	110620340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110620340C>T	ENST00000338882.4	-	4	570	c.571G>A	c.(571-573)Gat>Aat	p.D191N		NM_001123364.1	NP_001116836.1	Q5JXM2	CF186_HUMAN	methyltransferase like 24	191						extracellular region											AAATGGGTATCATCACTTCCT	0.433000													32	40					0	0	1	0	0
CHRM5	1133	broad.mit.edu	37	15	34356394	34356394	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34356394C>T	ENST00000383263.5	+	3	2146	c.1476C>T	c.(1474-1476)ccC>ccT	p.P492P	CHRM5_ENST00000557872.1_Silent_p.P492P	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	492					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	CTGTCAACCCCATCTGCTATG	0.478000													23	74					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29044228	29044228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29044228C>T	ENST00000257189.4	+	9	1237	c.1154C>T	c.(1153-1155)cCt>cTt	p.P385L		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	385					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCATTCCGTCCTGCTTCCAAG	0.393000													20	70					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43268136	43268136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43268136G>A	ENST00000404209.4	-	2	458	c.362C>T	c.(361-363)aCc>aTc	p.T121I	PSG8_ENST00000406636.3_Intron|PSG8_ENST00000306511.4_Missense_Mutation_p.T121I|PSG8_ENST00000401467.2_Missense_Mutation_p.T121I	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	121	Ig-like V-type.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GATGTGTAAGGTGTAGGATCC	0.443000													144	569					0	0	1	0	0
GNAT2	2780	broad.mit.edu	37	1	110148694	110148694	+	Silent	SNP	G	G	T	rs140231308		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110148694G>T	ENST00000351050.3	-	6	804	c.618C>A	c.(616-618)tcC>tcA	p.S206S		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	206					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		TCTTTCTCTCGGATCTCTGCC	0.502000													30	63					1.61788e-16	1.62657e-16	1	1	0
PER2	8864	broad.mit.edu	37	2	239162337	239162337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239162337G>A	ENST00000254657.3	-	19	2606	c.2327C>T	c.(2326-2328)cCt>cTt	p.P776L	PER2_ENST00000254658.3_3'UTR|AC096574.4_ENST00000456601.1_RNA	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	776					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TCTTAGTCCAGGGGCAGCTAA	0.413000													10	12					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44235853	44235853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44235853G>A	ENST00000330884.4	-	3	473	c.353C>T	c.(352-354)cCc>cTc	p.P118L	SULT4A1_ENST00000249130.5_Missense_Mutation_p.P118L|SULT4A1_ENST00000540422.1_Intron	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	118					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GAGGTCAGAGGGCAGAAAGCG	0.597000													5	12					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132232403	132232403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132232403G>A	ENST00000265343.5	-	11	2298	c.1919C>T	c.(1918-1920)tCa>tTa	p.S640L	AFF4_ENST00000378595.3_Missense_Mutation_p.S640L	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	640					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GATTTCCCTTGATTTCTGGGA	0.423000													11	64					0	0	1	0	0
USP51	158880	broad.mit.edu	37	X	55513532	55513532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:55513532G>A	ENST00000500968.3	-	2	1923	c.1841C>T	c.(1840-1842)tCc>tTc	p.S614F	USP51_ENST00000586165.1_5'UTR	NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	614					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						CAAGGGAAAGGAGATAAAGGT	0.433000													7	22					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639174	7639174	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7639174G>A	ENST00000359156.4	-	10	2581	c.2379C>T	c.(2377-2379)tcC>tcT	p.S793S	CD163_ENST00000541972.1_Silent_p.S781S|CD163_ENST00000396620.3_Silent_p.S826S|CD163_ENST00000432237.2_Silent_p.S793S	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	793	SRCR 7.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GCCAAATGCGGGATTCTTTTC	0.507000													67	170					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167814979	167814979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167814979C>T	ENST00000367848.1	-	21	3050	c.2553G>A	c.(2551-2553)aaG>aaA	p.K851K	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.K943K|ADCY10_ENST00000545172.1_Silent_p.K790K			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	943					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTCTCTGGTCCTTGAGCCACA	0.498000													8	98					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10599661	10599661	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:10599661C>T	ENST00000226951.6	-	3	263	c.24G>A	c.(22-24)aaG>aaA	p.K8K	CLNK_ENST00000442825.2_5'UTR|CLNK_ENST00000507719.1_5'UTR	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	8					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						CTTTAGTTGTCTTTCTATTGC	0.338000													7	12					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49390836	49390836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49390836G>A	ENST00000421952.2	-	2	1844	c.1823C>T	c.(1822-1824)gCc>gTc	p.A608V		NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	608	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						CAGGGCCCCGGCGTAGGGCCC	0.736000													4	11					0	0	1	0	0
U66061.31	0	broad.mit.edu	37	7	142424724	142424724	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142424724C>T	ENST00000506718.1	+	0	1590																											CTGCAGCTGGCTGTGCAGCAC	0.478000													5	7					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206331108	206331108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206331108G>A	ENST00000361052.3	+	9	1247	c.1129G>A	c.(1129-1131)Gat>Aat	p.D377N	CTSE_ENST00000358184.2_Missense_Mutation_p.D372N|CTSE_ENST00000360218.2_Silent_p.G324G|CTSE_ENST00000432969.2_Silent_p.G249G			P14091	CATE_HUMAN	cathepsin E	377					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GATCCTGGGGGATGTCTTCAT	0.562000													55	129					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480282	140480282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140480282C>T	ENST00000231130.2	+	1	49	c.49C>T	c.(49-51)Ctc>Ttc	p.L17F	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		17					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTCTTGCTTCTCTTTGTTTT	0.502000													8	68					0	0	1	0	0
SLC37A1	54020	broad.mit.edu	37	21	43959657	43959657	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43959657A>T	ENST00000352133.2	+	6	1368	c.386A>T	c.(385-387)tAc>tTc	p.Y129F	SLC37A1_ENST00000398341.3_Missense_Mutation_p.Y129F			P57057	GLPT_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 1	129					carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						ATTAGGTATTACCTAACTTTC	0.507000													23	75					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102441	22102441	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22102441G>A	ENST00000542433.1	-	1	655	c.558C>T	c.(556-558)atC>atT	p.I186I		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		ATACTGCGCGGATGTCACAGA	0.547000													14	120					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39581281	39581281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39581281G>A	ENST00000265707.5	+	19	2077	c.2032G>A	c.(2032-2034)Gaa>Aaa	p.E678K	ADAM18_ENST00000523755.1_3'UTR|ADAM18_ENST00000541111.1_Missense_Mutation_p.E92K|ADAM18_ENST00000379866.1_Missense_Mutation_p.E654K	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	678					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CTTTTATACTGAAAAAGGCTA	0.299000													35	71					0	0	1	0	0
EXOC3L2	90332	broad.mit.edu	37	19	45731469	45731469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45731469C>T	ENST00000413988.1	-	3	186	c.146G>A	c.(145-147)gGg>gAg	p.G49E	EXOC3L2_ENST00000252482.3_Missense_Mutation_p.G49E	NM_138568.3	NP_612635.3	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	49										endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		CTCCAGGCTCCCCCAGTGCTC	0.667000													49	109					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36340552	36340552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36340552C>T	ENST00000378910.5	-	6	611	c.612G>A	c.(610-612)gtG>gtA	p.V204V	NPHS1_ENST00000353632.6_Silent_p.V204V	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	204	Ig-like C2-type 2.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCCGGGGTGTCACCCTGGGAT	0.552000													19	64					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534248	92534248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92534248C>T	ENST00000298047.6	+	9	8086	c.8069C>T	c.(8068-8070)tCc>tTc	p.S2690F	FAT3_ENST00000525166.1_Missense_Mutation_p.S2540F|FAT3_ENST00000409404.2_Missense_Mutation_p.S2690F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2690	Cadherin 24.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTAAAGCACTCCCTCATTCCT	0.448000										TCGA Ovarian(4;0.039)			14	35					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58551905	58551905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58551905C>T	ENST00000282326.1	+	4	705	c.458C>T	c.(457-459)cCa>cTa	p.P153L		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	153					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CAGAAAGAACCATCGCAGGTG	0.622000													29	115					0	0	1	0	0
IL13	3596	broad.mit.edu	37	5	131995155	131995155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131995155G>A	ENST00000304506.3	+	2	234	c.220G>A	c.(220-222)Gct>Act	p.A74T	AC004041.2_ENST00000435042.1_RNA|IL13_ENST00000468334.1_3'UTR	NM_002188.2	NP_002179.2	P35225	IL13_HUMAN	interleukin 13	74					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			large_intestine(1)|lung(1)|ovary(1)|skin(3)	6		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAACCTGACAGCTGGCATGGT	0.602000													3	17					0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202457675	202457675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202457675C>T	ENST00000406302.3	+	14	2018	c.1865C>T	c.(1864-1866)cCt>cTt	p.P622L	PPP1R12B_ENST00000290419.5_3'UTR|PPP1R12B_ENST00000391959.3_5'UTR|PPP1R12B_ENST00000367270.4_5'UTR|PPP1R12B_ENST00000336894.4_Missense_Mutation_p.P622L	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B	622					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			TATCTGACTCCTGTACGGGAT	0.428000													4	21					0	0	1	0	0
ITPK1	3705	broad.mit.edu	37	14	93483112	93483112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93483112G>A	ENST00000267615.6	-	4	328	c.155C>T	c.(154-156)cCc>cTc	p.P52L	ITPK1_ENST00000354313.3_Missense_Mutation_p.P52L|ITPK1_ENST00000555495.1_5'UTR|ITPK1_ENST00000556603.2_Missense_Mutation_p.P52L|ITPK1_ENST00000556954.1_5'UTR			Q13572	ITPK1_HUMAN	inositol-tetrakisphosphate 1-kinase	52					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)	11		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		GACGTCCAGGGGGCCCTGCTC	0.577000													22	81					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60695935	60695935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:60695935G>A	ENST00000335712.6	-	3	646	c.419C>T	c.(418-420)cCt>cTt	p.P140L	BCL11A_ENST00000538214.1_Intron|BCL11A_ENST00000359629.5_Missense_Mutation_p.P140L|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000356842.4_Missense_Mutation_p.P140L|BCL11A_ENST00000537768.1_5'UTR|BCL11A_ENST00000358510.4_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	140	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGCAGAACGAGGGGAGGAGAG	0.473000			T	IGH@	B-CLL								6	64					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13678033	13678033	+	Silent	SNP	C	C	T	rs17854691		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13678033C>T	ENST00000404922.3	+	17	3422	c.3303C>T	c.(3301-3303)ttC>ttT	p.F1101F	FBLN2_ENST00000535798.1_Silent_p.F1080F|FBLN2_ENST00000492059.1_Silent_p.F1101F|FBLN2_ENST00000295760.7_Silent_p.F1054F	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	1054	Domain III.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent	p.F520F(1)|p.F1101F(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GCCTGCGCTTCGAGTGTCCTC	0.592000													8	19					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28209208	28209208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:28209208G>A	ENST00000344423.5	-	7	1168	c.1037C>T	c.(1036-1038)cCt>cTt	p.P346L	ZNF395_ENST00000523095.1_Missense_Mutation_p.P346L|ZNF395_ENST00000523202.1_Missense_Mutation_p.P346L	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	346					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGGAGTCCCAGGGACTGGGGT	0.627000													11	98					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103029809	103029809	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103029809G>A	ENST00000306312.3	-	13	1635	c.1374C>T	c.(1372-1374)ctC>ctT	p.L458L	SLC26A5_ENST00000393730.1_Intron|SLC26A5_ENST00000432958.2_Intron|SLC26A5_ENST00000393729.1_Silent_p.L421L|SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000339444.6_Silent_p.L458L|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000393727.1_Silent_p.L458L|SLC26A5_ENST00000393735.2_Silent_p.L458L|SLC26A5_ENST00000393723.1_Intron	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	458					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						AGAAAAAGGGGAGATCTGAGA	0.438000													28	73					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124253009	124253009	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124253009G>A	ENST00000375013.2	-	1	249	c.231C>T	c.(229-231)ttC>ttT	p.F77F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F77L(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TTTTGGGAGTGAAAACAGAGG	0.388000													49	115					0	0	1	0	0
FBXW11	23291	broad.mit.edu	37	5	171318532	171318532	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:171318532A>T	ENST00000296933.6	-	6	1059	c.689T>A	c.(688-690)gTc>gAc	p.V230D	FBXW11_ENST00000393802.2_Missense_Mutation_p.V209D|FBXW11_ENST00000265094.5_Missense_Mutation_p.V243D|FBXW11_ENST00000425623.2_Missense_Mutation_p.V211D|FBXW11_ENST00000522891.1_5'UTR	NM_033644.2|NM_033645.2	NP_387448.2|NP_387449.2	Q9UKB1	FBW1B_HUMAN	F-box and WD repeat domain containing 11	243					cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of circadian rhythm|positive regulation of proteolysis|positive regulation of transcription, DNA-dependent|protein dephosphorylation|protein destabilization|protein polyubiquitination|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	centrosome|cytosol|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(2)|urinary_tract(2)	21	Renal(175;0.000159)|Lung NSC(126;0.00384)|all_lung(126;0.00659)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TAAACAGTAGACACCTTTACT	0.373000													21	51					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884347	228884347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228884347G>A	ENST00000392056.3	-	7	1269	c.1223C>T	c.(1222-1224)tCt>tTt	p.S408F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S408F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	408						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTGAGATTGAGATAATCTAAT	0.438000													26	91					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958354	121958354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121958354G>A	ENST00000379692.4	-	4	1298	c.772C>T	c.(772-774)Cct>Tct	p.P258S	NDNF_ENST00000506900.1_5'UTR	NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	258										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						TTATCAGAAGGAAATCCAAAG	0.468000													23	44					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68631940	68631940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68631940C>T	ENST00000423218.2	-	11	1269	c.1174G>A	c.(1174-1176)Gga>Aga	p.G392R	ITGA11_ENST00000315757.7_Missense_Mutation_p.G392R			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	392					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	AGCACAGCTCCATTCCAGTCA	0.587000													43	55					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957581	49957581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:49957581C>T	ENST00000376056.2	-	5	1906	c.1756G>A	c.(1756-1758)Gca>Aca	p.A586T	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000358526.2_Missense_Mutation_p.A595T|AKAP4_ENST00000376058.2_Missense_Mutation_p.A212T|AKAP4_ENST00000376064.3_Missense_Mutation_p.A586T			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	595					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					ACTGAAAGTGCTTTGGCACTT	0.468000													39	33					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44587924	44587924	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44587924G>A	ENST00000322927.2	-	15	2269	c.2169C>T	c.(2167-2169)ttC>ttT	p.F723F	ZNF335_ENST00000426788.1_Silent_p.F568F	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	723					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GCAGAGAGAAGAAGGGGCGAC	0.657000													5	79					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35644168	35644168	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:35644168C>T	ENST00000400445.3	+	9	1897	c.1363C>T	c.(1363-1365)Cag>Tag	p.Q455*	NBEA_ENST00000310336.4_Nonsense_Mutation_p.Q455*|NBEA_ENST00000540320.1_Nonsense_Mutation_p.Q455*|NBEA_ENST00000379939.2_Nonsense_Mutation_p.Q455*	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	455						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CACTGATGCTCAGCTCTGCCT	0.413000													14	20					0	0	1	0	0
GNA12	2768	broad.mit.edu	37	7	2770902	2770902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2770902G>A	ENST00000275364.3	-	4	1221	c.1059C>T	c.(1057-1059)gcC>gcT	p.A353A	GNA12_ENST00000396960.3_Silent_p.A205A|GNA12_ENST00000407653.1_Silent_p.A277A|AMZ1_ENST00000489665.1_Intron|GNA12_ENST00000407904.3_Silent_p.A294A|GNA12_ENST00000544127.1_Silent_p.A260A|GNA12_ENST00000491117.1_5'UTR	NM_007353.2	NP_031379.2	Q03113	GNA12_HUMAN	guanine nucleotide binding protein (G protein) alpha 12	353					G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)		CGGTGTCGATGGCGGTGGTGA	0.597000													26	57					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102548620	102548620	+	Silent	SNP	G	G	A	rs113093780		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102548620G>A	ENST00000334701.7	-	11	2564	c.2283C>T	c.(2281-2283)gaC>gaT	p.D761D	HSP90AA1_ENST00000216281.8_Silent_p.D639D	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	639					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	TAATGGAATGGTCAGGGTTTA	0.448000													97	232					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	138011385	138011385	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138011385C>T	ENST00000252854.4	+	6	952	c.765C>T	c.(763-765)ttC>ttT	p.F255F	OLFM1_ENST00000371793.3_Silent_p.F273F|OLFM1_ENST00000371796.3_Silent_p.F246F	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	273	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		ACAACCGCTTCGTACGTGAGT	0.567000													27	60					0	0	1	0	0
PER2	8864	broad.mit.edu	37	2	239169470	239169470	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239169470G>A	ENST00000254657.3	-	13	1820	c.1542_splice	c.e13+1	p.A514_splice	PER2_ENST00000254658.3_3'UTR	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	514					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		GAGACGTACGGCTCTCCTCCG	0.567000													128	342					0	0	1	0	0
SLC25A15	10166	broad.mit.edu	37	13	41379284	41379284	+	Silent	SNP	C	C	T	rs35434090	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:41379284C>T	ENST00000338625.4	+	4	581	c.345C>T	c.(343-345)ttC>ttT	p.F115F	SLC25A15_ENST00000478827.1_3'UTR	NM_014252.3	NP_055067.1	Q9Y619	ORNT1_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	115					cellular amino acid metabolic process|mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|stomach(1)|urinary_tract(1)	14		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.48e-08)|Epithelial(112;7.51e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000191)|GBM - Glioblastoma multiforme(144;0.00231)|BRCA - Breast invasive adenocarcinoma(63;0.0704)	L-Ornithine(DB00129)	CCGGTTCCTTCGCCTCTGCCT	0.547000													10	103					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48145556	48145556	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48145556G>A	ENST00000405493.2	-	4	413	c.204C>T	c.(202-204)gcC>gcT	p.A68A	RAPGEF3_ENST00000548919.1_Silent_p.A68A|RAPGEF3_ENST00000449771.2_Silent_p.A110A|RAPGEF3_ENST00000395358.3_Silent_p.A110A|RAPGEF3_ENST00000549151.1_Silent_p.A68A|RAPGEF3_ENST00000389212.3_Silent_p.A110A|RAPGEF3_ENST00000171000.4_Silent_p.A68A	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	68					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		TTGGGCAGGTGGCCAGCAGAT	0.627000													12	43					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86370529	86370529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:86370529C>T	ENST00000400286.2	-	2	713	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	39	LRRNT 1.					integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CCATCTTTTTCCTCACAATTG	0.393000													31	130					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72299375	72299375	+	Missense_Mutation	SNP	C	C	T	rs144093353		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72299375C>T	ENST00000263563.6	+	15	2033	c.1765C>T	c.(1765-1767)Ccc>Tcc	p.P589S		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		AAGCGAGCCTCCCCCAGGCAA	0.652000													18	51					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240404	126240404	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126240404T>A	ENST00000394329.3	+	1	2851	c.2838T>A	c.(2836-2838)aaT>aaA	p.N946K		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	946	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATGAAAAGAATGGCACTATTA	0.488000													18	43					0	0	1	0	0
TSHR	7253	broad.mit.edu	37	14	81422098	81422098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81422098C>T	ENST00000541158.2	+	2	396	c.74C>T	c.(73-75)tCg>tTg	p.S25L	TSHR_ENST00000342443.6_Missense_Mutation_p.S25L|TSHR_ENST00000554263.1_Missense_Mutation_p.S25L|TSHR_ENST00000298171.2_Missense_Mutation_p.S25L|TSHR_ENST00000557096.1_3'UTR|TSHR_ENST00000554435.1_Missense_Mutation_p.S25L			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	25					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	ATGGGGTGTTCGTCTCCACCC	0.607000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						42	99					0	0	1	0	0
FRK	2444	broad.mit.edu	37	6	116277770	116277770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116277770G>A	ENST00000606080.1	-	5	1249	c.803C>T	c.(802-804)tCa>tTa	p.S268L	FRK_ENST00000538210.1_Missense_Mutation_p.S126L	NM_002031.2	NP_002022.1	P42685	FRK_HUMAN	fyn-related kinase	268	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|skin(1)|urinary_tract(1)	27		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TGGATCCATTGAACCTGAAAC	0.433000													29	35					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61414215	61414215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61414215G>A	ENST00000395348.3	-	5	1205	c.569C>T	c.(568-570)cCc>cTc	p.P190L	SLC16A9_ENST00000395347.1_Missense_Mutation_p.P190L	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	190					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						AGATTGGAGGGGTCTCATCAG	0.408000													43	110					0	0	1	0	0
SEC23IP	11196	broad.mit.edu	37	10	121652342	121652342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:121652342C>T	ENST00000369075.3	+	1	120	c.48C>T	c.(46-48)tcC>tcT	p.S16S	SEC23IP_ENST00000543134.1_5'UTR	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	16	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CCTCCACTTCCTCATCGGGCA	0.627000													8	32					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50249785	50249785	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50249785C>T	ENST00000246801.3	-	6	1016	c.934G>A	c.(934-936)Ggc>Agc	p.G312S	TSKS_ENST00000358830.3_Missense_Mutation_p.G112S	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	312							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		ACGTAGGGGCCCTCGCCAGCC	0.701000													17	62					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64892501	64892501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:64892501G>A	ENST00000555709.1	+	10	1296	c.909G>A	c.(907-909)tgG>tgA	p.W303*	MTHFD1_ENST00000545908.1_Nonsense_Mutation_p.W359*|CTD-2555O16.2_ENST00000556640.1_RNA|MTHFD1_ENST00000216605.7_Nonsense_Mutation_p.W359*|MTHFD1_ENST00000555252.1_Nonsense_Mutation_p.W283*	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	303	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding	p.W303*(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CAGGAAAGTGGATGATTCAGT	0.338000													37	80					0	0	1	0	0
KRT39	390792	broad.mit.edu	37	17	39122681	39122681	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39122681T>A	ENST00000355612.2	-	1	463	c.428A>T	c.(427-429)tAc>tTc	p.Y143F	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	143	Coil 1B.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				GTAAGACAGGTAATCAGGACA	0.413000													46	74					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44932910	44932910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44932910C>T	ENST00000291187.4	-	6	2350	c.2028G>A	c.(2026-2028)aaG>aaA	p.K676K	ZNF229_ENST00000588931.1_Silent_p.K682K|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	682					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				ACGTATAGGGCTTTTTTCCCG	0.502000													47	117					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61802491	61802491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61802491C>T	ENST00000280772.1	-	43	13283	c.13092G>A	c.(13090-13092)acG>acA	p.T4364T	ANK3_ENST00000355288.2_Silent_p.T988T|ANK3_ENST00000503366.1_Silent_p.T1855T|ANK3_ENST00000373827.2_Silent_p.T1848T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4364					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTCTTTCTTCGTTTTCACCT	0.398000													49	145					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564328	176564328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176564328G>A	ENST00000367662.3	+	3	2752	c.1588G>A	c.(1588-1590)Gtg>Atg	p.V530M	PAPPA2_ENST00000367661.3_Missense_Mutation_p.V530M	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	530	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CTACCAGGTGGTGAACATCTG	0.527000													6	39					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886862	3886862	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3886862G>A	ENST00000319331.3	+	2	1298	c.537G>A	c.(535-537)ttG>ttA	p.L179L	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	179						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCAACAAATTGAAAGTTATTG	0.383000													56	167					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152402475	152402475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152402475C>T	ENST00000427231.2	-	135	20706	c.20504G>A	c.(20503-20505)cGa>cAa	p.R6835Q	NEB_ENST00000604864.1_Missense_Mutation_p.R6835Q|NEB_ENST00000603639.1_Missense_Mutation_p.R6835Q|NEB_ENST00000172853.10_Missense_Mutation_p.R5134Q|NEB_ENST00000397345.3_Missense_Mutation_p.R6835Q|NEB_ENST00000409198.1_Missense_Mutation_p.R5134Q	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	5134					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTATTTGTCTCGCATCTTCCT	0.343000													7	13					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108156525	108156525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108156525C>T	ENST00000273353.3	-	26	3213	c.3157G>A	c.(3157-3159)Gag>Aag	p.E1053K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1053						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GCTTTTCTCTCCTGCTCAAGG	0.423000													18	179					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233272030	233272030	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233272030C>T	ENST00000295453.3	+	3	271	c.219C>T	c.(217-219)atC>atT	p.I73I		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	73					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CTGCCAGGATCCTAAAAGGGC	0.602000													26	51					0	0	1	0	0
RARRES3	5920	broad.mit.edu	37	11	63313703	63313703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63313703G>A	ENST00000255688.3	+	4	518	c.470G>A	c.(469-471)aGa>aAa	p.R157K	RARRES3_ENST00000354445.2_Missense_Mutation_p.R157K|RARRES3_ENST00000537871.1_3'UTR	NM_004585.3	NP_004576.2	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene induced) 3	157					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			kidney(1)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	6						GCGATTAGGAGATACCAAAAA	0.532000													59	152					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95147382	95147382	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:95147382C>T	ENST00000354268.4	+	3	376	c.303C>T	c.(301-303)gtC>gtT	p.V101V	SMARCAD1_ENST00000457823.2_Silent_p.V101V			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	101					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		GTGAAGATGTCGTTTCCCCAA	0.303000													55	111					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215914768	215914768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215914768C>T	ENST00000366943.2	-	60	12046	c.11660G>A	c.(11659-11661)tGg>tAg	p.W3887*	USH2A_ENST00000307340.3_Nonsense_Mutation_p.W3887*			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3887	Fibronectin type-III 24.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGTGGCATCCACTTAATCTC	0.383000										HNSCC(13;0.011)			44	117					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94463552	94463552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94463552C>T	ENST00000370225.3	-	48	6680	c.6594G>A	c.(6592-6594)caG>caA	p.Q2198Q	ABCA4_ENST00000536513.1_Silent_p.Q468Q|ABCA4_ENST00000535881.1_Silent_p.Q317Q	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	2198					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GCCTCTCCCTCTGCACACTGC	0.567000													26	40					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72086592	72086592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72086592G>A	ENST00000265381.4	-	4	1538	c.1316C>T	c.(1315-1317)tCa>tTa	p.S439L		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	439	Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GGTTGGGAATGAAGCCAAGCT	0.353000													27	57					0	0	1	0	0
CES2	8824	broad.mit.edu	37	16	66975410	66975410	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66975410C>T	ENST00000317091.4	+	7	2093	c.1107_splice	c.e7-1	p.P370_splice	CES2_ENST00000417689.1_Splice_Site_p.P370_splice	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	306					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		TCCCCTCAGCCTTTCAAGATG	0.572000													22	49					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22700095	22700095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:22700095G>A	ENST00000376603.2	+	10	1820	c.1678G>A	c.(1678-1680)Gaa>Aaa	p.E560K	SPAG6_ENST00000376624.3_Missense_Mutation_p.E484K|SPAG6_ENST00000538630.1_Missense_Mutation_p.E459K|SPAG6_ENST00000313311.6_Intron|SPAG6_ENST00000376601.1_Missense_Mutation_p.E245K|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000490361.1_3'UTR			O75602	SPAG6_HUMAN	sperm associated antigen 6	484					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						TTACCCCGAGGAAATAGTGAG	0.363000													17	52					0	0	1	0	0
NFKB2	4791	broad.mit.edu	37	10	104159900	104159900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104159900C>T	ENST00000369966.3	+	15	1783	c.1533C>T	c.(1531-1533)atC>atT	p.I511I	NFKB2_ENST00000189444.6_Silent_p.I511I|NFKB2_ENST00000428099.1_Silent_p.I511I	NM_001077494.2	NP_001070962.1	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	511					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|skin(2)	23		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		TCTATGTCATCCACCACGCCC	0.632000			T	IGH@	B-NHL								7	67					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120491725	120491725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120491725G>A	ENST00000256646.2	-	16	2723	c.2504C>T	c.(2503-2505)gCt>gTt	p.A835V		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	835	EGF-like 22.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGAACAGGGAGCCAATACTGT	0.413000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome		OREG0013733	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	95					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46832474	46832474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46832474C>T	ENST00000339613.2	+	12	1538	c.1283C>T	c.(1282-1284)gCt>gTt	p.A428V	AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000300862.3_Missense_Mutation_p.A482V|HIF3A_ENST00000244303.6_Missense_Mutation_p.A415V|HIF3A_ENST00000420102.2_Missense_Mutation_p.A433V|HIF3A_ENST00000377670.4_Missense_Mutation_p.A484V|HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000600383.1_Missense_Mutation_p.A415V			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GATGCTGATGCTCTGGATTTG	0.582000													32	76					0	0	1	0	0
CETN1	1068	broad.mit.edu	37	18	580498	580498	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:580498G>A	ENST00000327228.3	+	1	132	c.90G>A	c.(88-90)aaG>aaA	p.K30K		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	30	EF-hand 1.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						AGGATCAGAAGCAAGAAGTTC	0.592000													16	29					0	0	1	0	0
PDS5B	23047	broad.mit.edu	37	13	33327494	33327494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33327494G>A	ENST00000315596.10	+	25	2947	c.2761G>A	c.(2761-2763)Gtg>Atg	p.V921M		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	921					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AGTAAGACAAGTGTTTGCCCA	0.383000													38	98					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131666102	131666102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:131666102C>T	ENST00000368648.3	-	9	901	c.829G>A	c.(829-831)Gac>Aac	p.D277N	EBF3_ENST00000355311.5_Missense_Mutation_p.D286N	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	286	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AAGAAGTTGTCGCCAATTATG	0.567000													34	38					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45557701	45557701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45557701C>T	ENST00000415258.1	+	16	2118	c.1977C>T	c.(1975-1977)atC>atT	p.I659I	LARS2_ENST00000467936.1_3'UTR|LARS2_ENST00000265537.3_Silent_p.I659I|LARS2_ENST00000414984.1_Silent_p.I616I			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	659					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	AGTATGGGATCGACACGATTC	0.483000													42	99					0	0	1	0	0
NXPH1	30010	broad.mit.edu	37	7	8790821	8790821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:8790821G>A	ENST00000405863.1	+	3	1149	c.238G>A	c.(238-240)Gaa>Aaa	p.E80K	NXPH1_ENST00000497400.1_3'UTR|NXPH1_ENST00000602349.1_5'UTR	NM_152745.2	NP_689958.1	P58417	NXPH1_HUMAN	neurexophilin 1	80	II.					extracellular region				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|ovary(1)	17		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		TGACACCCCAGAACCTTATTC	0.507000													30	40					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58155425	58155425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58155425C>T	ENST00000295956.4	+	45	7691	c.7526C>T	c.(7525-7527)tCc>tTc	p.S2509F	FLNB_ENST00000493452.1_Missense_Mutation_p.S2316F|FLNB_ENST00000490882.1_Missense_Mutation_p.S2540F|FLNB_ENST00000429972.2_Missense_Mutation_p.S2498F|FLNB_ENST00000419752.2_Missense_Mutation_p.S2329F|FLNB_ENST00000348383.5_Missense_Mutation_p.S2468F|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000358537.3_Missense_Mutation_p.S2485F|FLNB-AS1_ENST00000488720.1_RNA|FLNB_ENST00000484981.1_3'UTR	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2509	Interaction with FLNA 2.|Interaction with INPPL1.|Self-association site, tail (By similarity).				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCCAAGGCATCCTCGGACGCC	0.582000													40	89					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272760	81272760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81272760C>T	ENST00000520547.2	+	1	404	c.355C>T	c.(355-357)Ctt>Ttt	p.L119F		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	119					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TGAGGGAGACCTTGGCAAGGA	0.547000													16	166					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11758700	11758700	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11758700G>A	ENST00000381486.2	+	22	3999	c.3699G>A	c.(3697-3699)gtG>gtA	p.V1233V	GREB1_ENST00000234142.5_Silent_p.V1233V|GREB1_ENST00000396123.1_Silent_p.V231V	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1233						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CCTCATCCGTGGCGCCCGCTG	0.672000													7	22					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156640282	156640282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156640282G>A	ENST00000368223.3	-	4	3830	c.3698C>T	c.(3697-3699)cCt>cTt	p.P1233L		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1233	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGAGGCCCAGGGGCATCTTC	0.637000													68	141					0	0	1	0	0
USP2	9099	broad.mit.edu	37	11	119229819	119229819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119229819G>A	ENST00000260187.2	-	6	1381	c.1087C>T	c.(1087-1089)Cgc>Tgc	p.R363C	USP2_ENST00000455332.2_Missense_Mutation_p.R120C|USP2_ENST00000525735.1_Missense_Mutation_p.R154C	NM_004205.4	NP_004196.4	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2	363					cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	24		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		AGAAGAAAGCGAAGGAACTCC	0.527000													38	21					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20480926	20480926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20480926G>A	ENST00000573854.1	+	4	595	c.481G>A	c.(481-483)Gat>Aat	p.D161N	ACSM2A_ENST00000417235.2_Missense_Mutation_p.D82N|ACSM2A_ENST00000536134.1_De_novo_Start_InFrame|ACSM2A_ENST00000396104.2_Missense_Mutation_p.D161N|ACSM2A_ENST00000219054.6_Missense_Mutation_p.D161N|ACSM2A_ENST00000424070.1_Missense_Mutation_p.D161N|ACSM2A_ENST00000575690.1_Missense_Mutation_p.D161N|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	161					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						TGTTGCTGGGGATGAAGTCAT	0.448000													41	139					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55107474	55107474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:55107474C>T	ENST00000474759.1	+	36	3038	c.2990C>T	c.(2989-2991)tCc>tTc	p.S997F	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.S903F|CACNA2D3_ENST00000478261.1_Intron|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.S997F|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.S997F	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	997						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TCCAACAGGTCCTTTGTCATC	0.507000													18	47					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16925901	16925901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16925901G>A	ENST00000552788.1	+	18	4456	c.4456G>A	c.(4456-4458)Ggc>Agc	p.G1486S	NWD1_ENST00000523826.1_Missense_Mutation_p.G1280S|NWD1_ENST00000379808.3_3'UTR|NWD1_ENST00000524140.2_3'UTR|NWD1_ENST00000339803.6_Missense_Mutation_p.G1351S|NWD1_ENST00000549814.1_Missense_Mutation_p.G1444S			Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1486							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AACCACCAGTGGCTTCATTGC	0.488000													21	57					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14150715	14150715	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14150715G>A	ENST00000263379.2	+	4	652	c.527G>A	c.(526-528)tGg>tAg	p.W176*		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	176	Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						GAGGCGGCCTGGACCCTGGTG	0.587000													47	86					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39986644	39986644	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39986644C>T	ENST00000373257.3	+	17	2253	c.2162C>T	c.(2161-2163)tCt>tTt	p.S721F	LPIN3_ENST00000491528.1_3'UTR	NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	721	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				ATCCTTCTGTCTCCCAGCAGC	0.672000													21	84					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6012345	6012345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:6012345G>A	ENST00000259569.5	-	1	3273	c.3263C>T	c.(3262-3264)tCa>tTa	p.S1088L		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	1088					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCAAGTTGTGATACACATTC	0.353000													13	58					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45016647	45016647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:45016647G>A	ENST00000258787.7	-	2	255	c.119C>T	c.(118-120)aCc>aTc	p.T40I		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	40	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						ACCGATGTAGGTGTAGATGCG	0.617000													37	47					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287288	202287288	+	Silent	SNP	C	C	T	rs148517456	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202287288C>T	ENST00000367278.3	+	18	1946	c.1857C>T	c.(1855-1857)gcC>gcT	p.A619A	LGR6_ENST00000439764.2_Silent_p.A480A|LGR6_ENST00000255432.7_Silent_p.A567A	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	619						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						GCCTTCTAGCCTCAGTCGATG	0.627000													15	30					0	0	1	0	0
NUSAP1	51203	broad.mit.edu	37	15	41643234	41643234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41643234C>T	ENST00000260359.6	+	4	574	c.310C>T	c.(310-312)Cat>Tat	p.H104Y	NUSAP1_ENST00000450318.1_Missense_Mutation_p.H119Y|NUSAP1_ENST00000558123.1_3'UTR|NUSAP1_ENST00000560747.1_Missense_Mutation_p.H118Y|NUSAP1_ENST00000414849.2_Missense_Mutation_p.H119Y|NUSAP1_ENST00000450592.2_Missense_Mutation_p.H96Y|NUSAP1_ENST00000559596.1_Missense_Mutation_p.H119Y|NUSAP1_ENST00000560177.1_Missense_Mutation_p.H118Y	NM_001243142.1|NM_001243143.1|NM_016359.4|NM_018454.7	NP_001230071.1|NP_001230072.1|NP_057443.2|NP_060924.4	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	119					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)|ovary(1)|prostate(2)|urinary_tract(2)	13		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		ATTCCAGAATCATGAAAAGCA	0.378000													11	23					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328089	126328089	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126328089C>T	ENST00000394329.3	+	3	5375	c.5362C>T	c.(5362-5364)Cgc>Tgc	p.R1788C	FAT4_ENST00000335110.5_Missense_Mutation_p.R86C	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1788	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGATAGTTTTCGCATCGACCC	0.463000													50	92					0	0	1	0	0
MOCS2	4338	broad.mit.edu	37	5	52394456	52394456	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52394456C>A	ENST00000396954.3	-	7	1220	c.543G>T	c.(541-543)gaG>gaT	p.E181D	MOCS2_ENST00000361377.4_3'UTR|MOCS2_ENST00000582677.1_3'UTR|MOCS2_ENST00000510818.2_3'UTR|MOCS2_ENST00000584946.1_3'UTR|MOCS2_ENST00000508922.1_3'UTR|MOCS2_ENST00000450852.3_3'UTR	NM_004531.3	NP_004522.1	O96033	MOC2A_HUMAN	molybdenum cofactor synthesis 2	0					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex	nucleotide binding			endometrium(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(810;3.08e-05)|Breast(144;0.0848)				CCCAAAAGCACTCTTTGTTTC	0.279000													29	81					8.16721e-17	8.21195e-17	1	1	0
ADCY5	111	broad.mit.edu	37	3	123039618	123039618	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123039618C>T	ENST00000462833.1	-	9	3301	c.2088_splice	c.e9-1	p.G697_splice	ADCY5_ENST00000309879.5_Splice_Site_p.G347_splice|ADCY5_ENST00000491190.1_Splice_Site_p.G330_splice	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	697					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TCTTCAAAGCCCTagaagaga	0.473000													8	27					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2944669	2944669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2944669C>T	ENST00000520002.1	-	50	7982	c.7427G>A	c.(7426-7428)cGa>cAa	p.R2476Q	CSMD1_ENST00000542608.1_Missense_Mutation_p.R2475Q|CSMD1_ENST00000400186.3_Missense_Mutation_p.R2476Q|CSMD1_ENST00000602557.1_Missense_Mutation_p.R2476Q|CSMD1_ENST00000537824.1_Missense_Mutation_p.R2475Q|CSMD1_ENST00000602723.1_Missense_Mutation_p.R2476Q			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2476	Sushi 14.					integral to membrane		p.R2204P(1)|p.R2204Q(1)|p.R2475P(1)|p.R2475Q(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAGTGGGTTTCGTCTACAGGT	0.507000													12	42					0	0	1	0	0
S1PR5	53637	broad.mit.edu	37	19	10625613	10625613	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10625613G>A	ENST00000439028.3	-	2	200	c.75C>T	c.(73-75)ctC>ctT	p.L25L	S1PR5_ENST00000333430.4_Silent_p.L25L	NM_001166215.1	NP_001159687.1	Q9H228	S1PR5_HUMAN	sphingosine-1-phosphate receptor 5	25						integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	12						GCGCACCGCGGAGCTTGCCGG	0.692000													17	56					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149482623	149482623	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149482623G>A	ENST00000378016.2	+	0	3039							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCAGTGGGCGGTGCCAGGCAT	0.672000													4	8					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53345105	53345105	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53345105G>A	ENST00000595646.1	-	4	562	c.442C>T	c.(442-444)Ctg>Ttg	p.L148L	ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000396409.4_Silent_p.L95L|ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Silent_p.L95L			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		GGTTCAGGCAGATGCAAATGA	0.403000													30	309					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062075	9062075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9062075C>T	ENST00000397910.4	-	3	25574	c.25371G>A	c.(25369-25371)agG>agA	p.R8457R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8459	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGATGTTCCCCTAGAGGATA	0.512000													39	156					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402247	89402247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89402247C>T	ENST00000439576.2	+	12	6805	c.6431C>T	c.(6430-6432)tCc>tTc	p.S2144F	ACAN_ENST00000352105.7_Missense_Mutation_p.S2144F|ACAN_ENST00000559004.1_Missense_Mutation_p.S2144F|ACAN_ENST00000561243.1_Missense_Mutation_p.S2144F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2144					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTTGAGAGATCCTCTGGCCTA	0.572000													28	145					0	0	1	0	0
WHAMM	123720	broad.mit.edu	37	15	83499498	83499498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83499498C>T	ENST00000286760.4	+	9	1888	c.1789C>T	c.(1789-1791)Ccc>Tcc	p.P597S		NM_001080435.1	NP_001073904.1	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi membranes and microtubules	597						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding			endometrium(6)|large_intestine(5)|lung(1)|prostate(1)	13						TAGAGGTGTTCCCCTATCGGA	0.488000													26	75					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49052746	49052746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:49052746G>A	ENST00000226432.4	+	15	2084	c.1901G>A	c.(1900-1902)aGt>aAt	p.S634N	CWH43_ENST00000513409.1_Missense_Mutation_p.S607N	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	634					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						GCTGAACTGAGTGATTCAGAA	0.383000													34	70					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782677	54782677	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54782677G>A	ENST00000391748.1	-	6	1072	c.945C>T	c.(943-945)atC>atT	p.I315I	LILRB2_ENST00000391746.1_Silent_p.I315I|LILRB2_ENST00000314446.5_Silent_p.I315I|LILRB2_ENST00000434421.1_Silent_p.I199I|LILRB2_ENST00000391749.4_Silent_p.I315I	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	315	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGTGATCAGGATGTCCAGGG	0.652000													22	20					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406212	55406212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55406212C>T	ENST00000314612.2	+	1	379	c.379C>T	c.(379-381)Ccc>Tcc	p.P127S		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						CATTTGCAAGCCCCTGCACTA	0.418000													22	76					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132399036	132399036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:132399036C>T	ENST00000331898.7	-	3	1023	c.445G>A	c.(445-447)Gag>Aag	p.E149K	OPCML_ENST00000374778.4_Missense_Mutation_p.E108K|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000524381.1_Missense_Mutation_p.E142K|OPCML_ENST00000541867.1_Missense_Mutation_p.E149K	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	149	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CTGCTTCCCTCATTCACAGTG	0.463000													23	60					0	0	1	0	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216779	26216779	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26216779C>T	ENST00000244601.3	-	1	93	c.93G>A	c.(91-93)aaG>aaA	p.K31K		NM_003518.3	NP_003509.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	31					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	8		all_hematologic(11;0.196)				TACGACTGCGCTTGCGCTTCT	0.527000													58	230					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51675865	51675865	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51675865C>T	ENST00000409535.1	+	14	2457	c.2332C>T	c.(2332-2334)Cga>Tga	p.R778*	RAD54L2_ENST00000296477.3_Nonsense_Mutation_p.R472*	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	778	Helicase C-terminal.					nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		GAAGTGGGTTCGAAACATCAG	0.493000													9	8					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599818	136599818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136599818C>T	ENST00000531224.1	-	4	453	c.201G>A	c.(199-201)atG>atA	p.M67I	BCLAF1_ENST00000527536.1_Missense_Mutation_p.M67I|BCLAF1_ENST00000527759.1_Missense_Mutation_p.M65I|BCLAF1_ENST00000392348.2_Missense_Mutation_p.M65I|BCLAF1_ENST00000530767.1_Missense_Mutation_p.M67I|BCLAF1_ENST00000353331.4_Missense_Mutation_p.M65I	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	67					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAGGTCGTCTCATTCCTCTAT	0.428000													9	87					0	0	1	0	0
CYP2F1	1572	broad.mit.edu	37	19	41627980	41627980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41627980C>T	ENST00000331105.2	+	6	836	c.764C>T	c.(763-765)tCg>tTg	p.S255L		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	255					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						CACCAGGCCTCGCTAGACCCC	0.587000													4	58					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70189923	70189923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70189923C>T	ENST00000253925.7	+	15	2071	c.1856C>T	c.(1855-1857)cCc>cTc	p.P619L	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Missense_Mutation_p.P619L	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	619					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CTGCTATCGCCCAGCGGGCAG	0.552000													7	42					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68810254	68810254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68810254C>T	ENST00000508048.1	-	3	267	c.232G>A	c.(232-234)Gag>Aag	p.E78K	TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.E79K|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.E79K			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	79	SEA.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TCGGTCGTCTCTCGTAAGTCC	0.338000													45	111					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528284	20528284	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20528284C>T	ENST00000315683.1	+	1	81	c.81C>T	c.(79-81)ttC>ttT	p.F27F		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F27L(1)		central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAATTTTCTTCTTTGTGACAT	0.383000													91	219					0	0	1	0	0
SNORD113-6	767566	broad.mit.edu	37	14	101405917	101405917	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101405917G>A	ENST00000363345.2	+	0	25					NR_003234.1																						ATATCATGGGGTTTCTGAAAC	0.358000													19	42					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96706530	96706530	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:96706530G>A	ENST00000389672.5	+	3	845	c.807G>A	c.(805-807)gaG>gaA	p.E269E	EPHA6_ENST00000542517.1_Silent_p.E175E|EPHA6_ENST00000470610.2_Silent_p.E269E	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	174						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AAATTCGTGAGGTGGGGCCTA	0.448000													52	283					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128177561	128177561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128177561G>A	ENST00000453608.2	+	2	114	c.106G>A	c.(106-108)Gga>Aga	p.G36R	PROC_ENST00000409048.1_Missense_Mutation_p.G15R|PROC_ENST00000422777.3_Missense_Mutation_p.G15R|PROC_ENST00000234071.3_Missense_Mutation_p.G15R			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	15					blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	GGCCACCTGGGGAATTTCCGG	0.642000													18	50					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105349891	105349891	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105349891G>A	ENST00000369780.4	+	6	1896	c.1486_splice	c.e6-1	p.G496_splice	NEURL_ENST00000369777.2_Splice_Site_p.G479_splice|SH3PXD2A_ENST00000427662.2_Intron	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		496					nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TTGTCCTCAGGGACAGCCCCC	0.632000													40	149					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150906174	150906174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:150906174G>A	ENST00000474524.1	+	12	1698	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K	MED12L_ENST00000309237.4_Missense_Mutation_p.E554K|MED12L_ENST00000273432.4_Missense_Mutation_p.E414K|MED12L_ENST00000422248.2_Missense_Mutation_p.E554K	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	554					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGATGAGAAGGAGTCTATTTC	0.353000													35	76					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770253	53770253	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53770253G>A	ENST00000311170.4	-	1	719	c.666C>T	c.(664-666)tcC>tcT	p.S222S		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	222					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		AGGCTCTGGGGGAGAGATTGC	0.537000										HNSCC(26;0.072)			8	17					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6505811	6505811	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6505811A>T	ENST00000377828.1	+	7	1448	c.1280A>T	c.(1279-1281)aAg>aTg	p.K427M	RP1-202O8.2_ENST00000419034.1_RNA	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	427					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		ACGATTGGGAAGcccacaccc	0.687000													7	11					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135413078	135413078	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135413078G>A	ENST00000343036.2	+	5	771	c.723G>A	c.(721-723)ctG>ctA	p.L241L	C9orf171_ENST00000393216.2_Silent_p.L205L	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	241										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						CCATCAAACTGGAGAAGAAGC	0.557000													28	77					0	0	1	0	0
AJUBA	84962	broad.mit.edu	37	14	23443310	23443310	+	Silent	SNP	G	G	A	rs146599877	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23443310G>A	ENST00000262713.2	-	7	1812	c.1437C>T	c.(1435-1437)atC>atT	p.I479I	RP11-298I3.5_ENST00000555074.1_Intron|AJUBA_ENST00000397388.3_Silent_p.I62I|AJUBA_ENST00000361265.4_Silent_p.I479I	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	479	LIM zinc-binding 3.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										TCACCCTCACGATGTCCTCAC	0.537000											OREG0022591	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	57	143					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53678703	53678703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53678703G>A	ENST00000396424.3	-	3	226	c.137C>T	c.(136-138)tCc>tTc	p.S46F	ZNF665_ENST00000600412.1_Intron	NM_024733.3	NP_079009.3	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		CTCACCCAGGGAGACCAGGTT	0.483000													56	145					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126771152	126771152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:126771152C>T	ENST00000274473.6	+	17	2342	c.2075C>T	c.(2074-2076)cCc>cTc	p.P692L	MEGF10_ENST00000503335.2_Missense_Mutation_p.P692L	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	692	EGF-like 12.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CAGTGTTACCCCGGTTGGATT	0.418000													8	52					0	0	1	0	0
DOK2	9046	broad.mit.edu	37	8	21769936	21769936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:21769936G>A	ENST00000276420.4	-	2	407	c.149C>T	c.(148-150)cCt>cTt	p.P50L	DOK2_ENST00000544659.1_5'UTR	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	50	PH.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		ACACCGACGAGGCTTCTCCGG	0.711000													4	10					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75107456	75107456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:75107456C>T	ENST00000290573.2	+	10	1930	c.1330C>T	c.(1330-1332)Cgc>Tgc	p.R444C	HK2_ENST00000409174.1_Missense_Mutation_p.R416C	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	444	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						CCGCTTCCTCCGCTCCGAGGA	0.617000													113	228					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771318	143771318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143771318G>A	ENST00000408898.2	+	1	44	c.6G>A	c.(4-6)ggG>ggA	p.G2G		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					GGGAAATGGGGGGAAATCAGA	0.443000													25	98					0	0	1	0	0
FAM118A	55007	broad.mit.edu	37	22	45723824	45723824	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45723824C>T	ENST00000216214.3	+	5	1236	c.402C>T	c.(400-402)atC>atT	p.I134I	FAM118A_ENST00000441876.2_Silent_p.I134I|FAM118A_ENST00000405673.1_Silent_p.I134I	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	134						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TGCAGTCGATCCTCAGCCTGA	0.617000													11	41					0	0	1	0	0
CTRC	11330	broad.mit.edu	37	1	15766993	15766993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15766993C>T	ENST00000375949.4	+	3	163	c.137C>T	c.(136-138)tCc>tTc	p.S46F	CTRC_ENST00000375943.2_Intron|CTRC_ENST00000483406.1_3'UTR	NM_007272.2	NP_009203.2	Q99895	CTRC_HUMAN	chymotrypsin C (caldecrin)	46	Peptidase S1.				proteolysis		serine-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)	13		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCAGATCTCCCTCCAGTAC	0.617000													16	21					0	0	1	0	0
NIPAL1	152519	broad.mit.edu	37	4	48035011	48035011	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48035011G>A	ENST00000295461.5	+	4	438	c.370_splice	c.e4-1	p.M124_splice	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	124						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						GCTTTCTAGTGGGAGCAGGAG	0.428000													12	44					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131118023	131118023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131118023C>T	ENST00000300456.3	+	12	1839	c.1722C>T	c.(1720-1722)ccC>ccT	p.P574P	SLC27A4_ENST00000372870.1_Silent_p.P168P	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	574					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						AGGAACTGCCCCTGTATGCGC	0.652000													21	74					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152328286	152328286	+	Missense_Mutation	SNP	C	C	T	rs145112487		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152328286C>T	ENST00000388718.5	-	3	2048	c.1976G>A	c.(1975-1977)gGa>gAa	p.G659E	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	659	Ser-rich.						calcium ion binding|structural molecule activity	p.G659E(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGCCTGATCCATATTGGCC	0.493000													142	377					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594905	179594905	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179594905G>A	ENST00000589042.1	-	62	18446	c.18222C>T	c.(18220-18222)gcC>gcT	p.A6074A	TTN_ENST00000342992.6_Silent_p.A4830A|TTN_ENST00000591111.1_Silent_p.A5757A|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5757	Ig-like 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGTAGCTTTGGCTGCAAAGA	0.448000													5	41					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64212957	64212957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64212957C>T	ENST00000205948.6	-	6	770	c.733G>A	c.(733-735)Gaa>Aaa	p.E245K		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	245	Sushi 4.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			CATTCTATTTCTTCCGGGCCA	0.418000													49	111					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643428	37643428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37643428C>T	ENST00000356958.4	-	5	1631	c.1373G>A	c.(1372-1374)cGa>cAa	p.R458Q	ZNF585A_ENST00000355533.2_Intron|ZNF585A_ENST00000292841.5_Missense_Mutation_p.R403Q|ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000392157.2_Missense_Mutation_p.R403Q			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	458					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding	p.R403Q(1)		breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTGTGAATTCGTTTATGAAC	0.398000													52	161					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18524229	18524229	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18524229C>T	ENST00000433979.1	+	12	1857	c.1741C>T	c.(1741-1743)Cca>Tca	p.P581S	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.P581S|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.P622S	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	581					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GACTTGTCTTCCACTGTTTCC	0.358000													9	32					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23874889	23874889	+	Missense_Mutation	SNP	C	C	T	rs140596256	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23874889C>T	ENST00000405093.3	-	4	362	c.292G>A	c.(292-294)Gag>Aag	p.E98K	MYH6_ENST00000356287.3_Missense_Mutation_p.E98K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	98	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ACCGCGGGCTCGTGCAGGAAG	0.592000													18	71					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138566163	138566163	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138566163G>A	ENST00000440172.1	-	11	4248	c.4200C>T	c.(4198-4200)atC>atT	p.I1400I	KIAA1549_ENST00000422774.1_Silent_p.I1400I|KIAA1549_ENST00000242365.4_Silent_p.I1350I	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1400						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TCTTGGAAGGGATCTTTGACT	0.473000			O	BRAF	pilocytic astrocytoma								32	71					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3087637	3087637	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3087637G>A	ENST00000520002.1	-	28	4828	c.4273C>T	c.(4273-4275)Caa>Taa	p.Q1425*	CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000542608.1_Nonsense_Mutation_p.Q1424*|CSMD1_ENST00000400186.3_Nonsense_Mutation_p.Q1425*|CSMD1_ENST00000602557.1_Nonsense_Mutation_p.Q1425*|CSMD1_ENST00000537824.1_Nonsense_Mutation_p.Q1424*|CSMD1_ENST00000602723.1_Nonsense_Mutation_p.Q1425*|CSMD1_ENST00000539096.1_Nonsense_Mutation_p.Q1424*			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1425	Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTTGTCCTTGGAGCTGATAG	0.502000													12	31					0	0	1	0	0
SRSF2	6427	broad.mit.edu	37	17	74733199	74733199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74733199G>A	ENST00000392485.2	-	1	216	c.44C>T	c.(43-45)tCc>tTc	p.S15F	SRSF2_ENST00000359995.5_Missense_Mutation_p.S15F|SRSF2_ENST00000508921.3_Missense_Mutation_p.S15F|MFSD11_ENST00000591864.1_Intron|MFSD11_ENST00000588460.1_5'UTR|RP11-318A15.7_ENST00000587459.1_Intron|MFSD11_ENST00000586622.1_Intron	NM_003016.4	NP_003007.2	Q01130	SRSF2_HUMAN	serine/arginine-rich splicing factor 2	15	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity			haematopoietic_and_lymphoid_tissue(320)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)	329						CACCTTGAGGGAGGTCATACC	0.687000			Mis		"""MDS, CLL"""								3	7					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6525594	6525594	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6525594G>A	ENST00000377782.3	-	2	133	c.66C>T	c.(64-66)gcC>gcT	p.A22A	TNFRSF25_ENST00000461703.2_5'UTR|TNFRSF25_ENST00000356876.3_Silent_p.A22A|TNFRSF25_ENST00000351748.3_Silent_p.A22A|TNFRSF25_ENST00000348333.3_Silent_p.A22A|TNFRSF25_ENST00000351959.5_Silent_p.A22A	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	22					apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGGGCCCGGGCCCCCAGCA	0.652000													14	23					0	0	1	0	0
MCHR1	2847	broad.mit.edu	37	22	41075531	41075531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41075531G>A	ENST00000249016.4	+	1	778	c.82G>A	c.(82-84)Gac>Aac	p.D28N	MCHR1_ENST00000381433.2_Missense_Mutation_p.D28N|MCHR1_ENST00000498400.1_Intron	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	28			D -> V.		elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						TACGGAGGAAGACCCCCTTCC	0.652000													16	35					0	0	1	0	0
FNDC9	408263	broad.mit.edu	37	5	156770210	156770210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156770210G>A	ENST00000312349.4	-	2	522	c.335C>T	c.(334-336)tCc>tTc	p.S112F	CYFIP2_ENST00000541131.1_Intron|CYFIP2_ENST00000318218.6_Intron|CYFIP2_ENST00000442283.2_Intron|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000521420.1_Intron|CYFIP2_ENST00000347377.6_Intron|CYFIP2_ENST00000377576.3_Intron|CYFIP2_ENST00000435847.2_Intron	NM_001001343.3	NP_001001343.2	Q8TBE3	FNDC9_HUMAN	fibronectin type III domain containing 9	112						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	9						CACCCAAAGGGAGATCTGGGG	0.587000											OREG0016977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	62					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49726071	49726071	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49726071G>A	ENST00000449682.2	-	1	415	c.54C>T	c.(52-54)ctC>ctT	p.L18L	MST1_ENST00000545762.1_Silent_p.L4L|MST1_ENST00000494828.2_5'UTR|MST1_ENST00000383728.3_5'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	4					proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCAGGAGTGGGAGCCACCCCA	0.612000													8	15					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108389018	108389018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:108389018G>A	ENST00000263054.6	-	19	2611	c.2604C>T	c.(2602-2604)acC>acT	p.T868T	SORCS1_ENST00000344440.6_Silent_p.T868T|SORCS1_ENST00000369698.1_Silent_p.T403T	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	868	PKD.					integral to membrane	neuropeptide receptor activity|protein binding	p.T868T(1)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCACCTGCACGGTCACACGGA	0.458000													22	28					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981878	61981878	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61981878G>A	ENST00000370263.4	-	5	1106	c.885C>T	c.(883-885)atC>atT	p.I295I	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	295					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TGGACGGGATGATCTCGGTGA	0.577000													27	62					0	0	1	0	0
RHBG	57127	broad.mit.edu	37	1	156351641	156351641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156351641G>A	ENST00000400992.2	+	6	1157	c.789G>A	c.(787-789)ggG>ggA	p.G263G	RHBG_ENST00000451864.2_Intron|RHBG_ENST00000368249.1_Silent_p.G295G|RHBG_ENST00000255013.3_Silent_p.G226G|RHBG_ENST00000368246.2_Silent_p.G295G|RHBG_ENST00000537040.1_Silent_p.G133G			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	295					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					TTGTGGTGGGGACCTCAAGTG	0.557000													24	64					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64974679	64974679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:64974679G>A	ENST00000399262.2	-	8	1466	c.1248C>T	c.(1246-1248)ccC>ccT	p.P416P	JMJD1C_ENST00000402544.1_Silent_p.P197P|JMJD1C_ENST00000542921.1_Silent_p.P234P|JMJD1C_ENST00000399251.1_Silent_p.P197P	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	416					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					CATTATTATGGGGTTTTCCTT	0.348000													18	57					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979755	12979755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12979755C>T	ENST00000361079.2	+	4	1030	c.947C>T	c.(946-948)cCg>cTg	p.P316L						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCTTGGTGCCCGAGCATCCGT	0.572000													49	101					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92523361	92523361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92523361G>A	ENST00000298047.6	+	7	4605	c.4588G>A	c.(4588-4590)Gac>Aac	p.D1530N	FAT3_ENST00000525166.1_Missense_Mutation_p.D1380N|FAT3_ENST00000409404.2_Missense_Mutation_p.D1530N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1530	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAGGCCCAGGACAAGCACAT	0.483000										TCGA Ovarian(4;0.039)			42	119					0	0	1	0	0
UPK1B	7348	broad.mit.edu	37	3	118909934	118909934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:118909934G>A	ENST00000264234.3	+	5	600	c.451G>A	c.(451-453)Gac>Aac	p.D151N	UPK1B_ENST00000460625.1_Missense_Mutation_p.D143N|UPK1B_ENST00000497685.1_Missense_Mutation_p.D71N	NM_006952.3	NP_008883.2	O75841	UPK1B_HUMAN	uroplakin 1B	151					epithelial cell differentiation	integral to membrane	structural molecule activity			breast(1)|endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	14				GBM - Glioblastoma multiforme(114;0.222)		CAAAACCTGGGACAGGCTCAT	0.493000													79	177					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98144361	98144361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98144361C>T	ENST00000357947.3	-	16	2402	c.2177G>A	c.(2176-2178)aGg>aAg	p.R726K		NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	726	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GAAGTGGGCCCTGAAGCCGCG	0.627000													43	102					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47398567	47398567	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47398567C>T	ENST00000285039.7	-	27	3872	c.3573G>A	c.(3571-3573)ccG>ccA	p.P1191P	MYO5B_ENST00000587895.1_5'UTR|MYO5B_ENST00000324581.6_Silent_p.P332P	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1191					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.P1191P(1)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GATCTGCATTCGGGTCCAAAT	0.507000													27	468					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402193	89402193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89402193C>T	ENST00000439576.2	+	12	6751	c.6377C>T	c.(6376-6378)tCc>tTc	p.S2126F	ACAN_ENST00000352105.7_Missense_Mutation_p.S2126F|ACAN_ENST00000559004.1_Missense_Mutation_p.S2126F|ACAN_ENST00000561243.1_Missense_Mutation_p.S2126F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2126					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GATTCTGGGTCCCCTGATCTG	0.552000													29	105					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102712909	102712909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102712909C>T	ENST00000299855.5	-	4	857	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	201					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	GTCCATTGTTCATCATCATCA	0.393000													29	60					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420437	55420437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55420437C>T	ENST00000242994.3	+	2	592	c.214C>T	c.(214-216)Ccc>Tcc	p.P72S		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	72					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						GAGAAGGGGTCCCAAGAAAAA	0.483000													10	39					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6203924	6203924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6203924C>T	ENST00000262450.3	-	13	2101	c.2002G>A	c.(2002-2004)Gac>Aac	p.D668N	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	668					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGCTTGTCGTCCCTCAGCTTC	0.642000													37	82					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424653	56424653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56424653C>T	ENST00000588751.1	-	5	554	c.530G>A	c.(529-531)aGa>aAa	p.R177K	NLRP13_ENST00000342929.3_Missense_Mutation_p.R177K			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	177							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTATTTTCTTCTGTGGTCTAG	0.413000													52	108					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15702076	15702076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15702076C>T	ENST00000281171.4	+	14	2683	c.2353C>T	c.(2353-2355)Cct>Tct	p.P785S	PTPRO_ENST00000542557.1_5'UTR|PTPRO_ENST00000348962.2_Missense_Mutation_p.P785S|PTPRO_ENST00000442921.2_5'UTR|PTPRO_ENST00000445537.2_5'UTR|PTPRO_ENST00000544244.1_5'UTR	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	785	Fibronectin type-III 8.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				CAGCCTTCTTCCTGCCACTGC	0.428000													80	173					0	0	1	0	0
CWC22	57703	broad.mit.edu	37	2	180846611	180846611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:180846611G>A	ENST00000410053.3	-	5	619	c.320C>T	c.(319-321)tCc>tTc	p.S107F	CWC22_ENST00000295749.6_Missense_Mutation_p.S107F	NM_020943.2	NP_065994.1	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	107						catalytic step 2 spliceosome	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(8)|stomach(1)	30						CTGAGCAGAGGAACTCTGAGT	0.473000													8	18					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55838477	55838477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:55838477G>A	ENST00000302000.6	-	3	1098	c.1004C>T	c.(1003-1005)tCg>tTg	p.S335L	PYGO1_ENST00000563719.1_Missense_Mutation_p.S335L	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	335					Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		GTCAGAAGACGAATGGCCATG	0.473000													96	213					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226923820	226923820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226923820G>A	ENST00000429204.1	-	2	1667	c.1340C>T	c.(1339-1341)tCc>tTc	p.S447F	ITPKB_ENST00000366784.1_Missense_Mutation_p.S447F|ITPKB_ENST00000272117.3_Missense_Mutation_p.S447F	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	447							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				CAGCGTTGGGGACCCTCCCTC	0.706000													27	70					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32157053	32157053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32157053G>A	ENST00000373672.3	-	19	1879	c.1363C>T	c.(1363-1365)Cct>Tct	p.P455S	COL16A1_ENST00000271069.6_Missense_Mutation_p.P455S|COL16A1_ENST00000373668.3_Missense_Mutation_p.P455S	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	455	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGGGTCCAGGGAGGCCGGGG	0.667000													4	47					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107125991	107125991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107125991G>A	ENST00000392842.1	+	14	1849	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K	RP11-482D24.3_ENST00000552415.1_RNA|RFX4_ENST00000357881.4_Missense_Mutation_p.E488K|RFX4_ENST00000229387.5_Missense_Mutation_p.E385K|RP11-144F15.1_ENST00000551505.1_Intron	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	479	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GCGGGCCAATGAGCTCATGCG	0.448000													31	118					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118753046	118753046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:118753046G>A	ENST00000376300.2	-	6	632	c.495C>T	c.(493-495)gcC>gcT	p.A165A	CCDC93_ENST00000319432.5_Silent_p.A165A|CCDC93_ENST00000460781.1_5'UTR	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	165										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						CTGTCTTGATGGCCTTTTCTT	0.433000													37	99					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7655151	7655151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7655151C>T	ENST00000359156.4	-	2	258	c.56G>A	c.(55-57)aGa>aAa	p.R19K	CD163_ENST00000541972.1_Missense_Mutation_p.R7K|CD163_ENST00000396620.3_Missense_Mutation_p.R19K|CD163_ENST00000432237.2_Missense_Mutation_p.R19K	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	19					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						gacaaaatgtcttctgaagtc	0.383000													3	9					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10415830	10415830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10415830C>T	ENST00000226207.5	-	12	1136	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	348	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GACACTCTTTCATCTGAAGTA	0.428000													23	72					0	0	1	0	0
SAV1	60485	broad.mit.edu	37	14	51132005	51132005	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51132005G>A	ENST00000324679.4	-	2	790	c.427C>T	c.(427-429)Cag>Tag	p.Q143*		NM_021818.3	NP_068590.1	Q9H4B6	SAV1_HUMAN	salvador homolog 1 (Drosophila)	143					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)|kidney(2)|lung(2)|prostate(1)	6	all_epithelial(31;0.000611)|Breast(41;0.0333)					CGCTTTCTCTGACCATCAAAA	0.403000													31	67					0	0	1	0	0
HIC1	3090	broad.mit.edu	37	17	1961664	1961664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:1961664G>A	ENST00000399849.2	+	2	1840	c.1680G>A	c.(1678-1680)acG>acA	p.T560T	HIC1_ENST00000322941.3_Silent_p.T579T	NM_006497.3	NP_006488.2	Q14526	HIC1_HUMAN	hypermethylated in cancer 1	579					multicellular organismal development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|lung(1)|prostate(1)	3				READ - Rectum adenocarcinoma(1115;0.236)		ACCGCCTCACGGAGCACATGC	0.657000													8	10					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121503	38121503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38121503C>T	ENST00000406386.3	+	7	3195	c.2940C>T	c.(2938-2940)tcC>tcT	p.S980S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	980					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CCTCTTCCTCCCATAACCCAG	0.642000													82	232					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61848091	61848091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61848091C>T	ENST00000280772.1	-	29	3545	c.3354G>A	c.(3352-3354)ggG>ggA	p.G1118G	ANK3_ENST00000355288.2_Silent_p.G252G|ANK3_ENST00000503366.1_Silent_p.G1119G|ANK3_ENST00000373827.2_Silent_p.G1112G	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1118					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TACGCTTTTTCCCTAACTCTT	0.393000													9	98					0	0	1	0	0
OR52M1	119772	broad.mit.edu	37	11	4567312	4567312	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4567312C>T	ENST00000360213.1	+	1	892	c.892C>T	c.(892-894)Cgc>Tgc	p.R298C		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTATGCTGTTCGCACCAAGCA	0.448000													32	53					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80752498	80752498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80752498G>A	ENST00000458043.2	+	50	6148	c.6142G>A	c.(6142-6144)Gat>Aat	p.D2048N	OTOGL_ENST00000546620.1_Missense_Mutation_p.D67N|OTOGL_ENST00000547103.1_Missense_Mutation_p.D2036N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CTGTGCAGAAGATATGAATCT	0.313000													10	44					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474453	140474453	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140474453C>T	ENST00000194155.4	+	1	227	c.79C>T	c.(79-81)Cag>Tag	p.Q27*		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		27					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCATAGCTCAGGCTAGTTG	0.522000													27	58					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96495170	96495170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96495170C>T	ENST00000285979.6	+	9	1641	c.1442C>T	c.(1441-1443)cCc>cTc	p.P481L	CYP2C18_ENST00000339022.5_Missense_Mutation_p.P422L|CYP2C19_ENST00000464755.1_Intron	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		CGTGTGCCACCCTTGTACCAG	0.493000													23	185					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125289062	125289062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125289062C>T	ENST00000304880.2	-	1	510	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						TGAGCAATTTCCCCAGTCACA	0.502000													9	35					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87683257	87683257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87683257C>T	ENST00000320005.5	-	4	455	c.408G>A	c.(406-408)gtG>gtA	p.V136V		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	136					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						GCATTCTTTTCACCAGGTTGT	0.468000													80	259					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286164	48286164	+	Missense_Mutation	SNP	C	C	T	rs143647867	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48286164C>T	ENST00000320048.1	+	1	752	c.752C>T	c.(751-753)cCt>cTt	p.P251L		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						TTCTTCATACCTTGCTCCTTG	0.498000													20	139					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815940	43815940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43815940G>A	ENST00000382031.1	+	5	3014	c.2983G>A	c.(2983-2985)Gat>Aat	p.D995N	MAP1A_ENST00000399453.1_Missense_Mutation_p.D757N|MAP1A_ENST00000300231.5_Missense_Mutation_p.D757N			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	757						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGAGATCCATGATGAGCCGGA	0.562000													10	28					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17531255	17531255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17531255G>A	ENST00000005226.7	-	18	1660	c.1661C>T	c.(1660-1662)cCc>cTc	p.P554L	USH1C_ENST00000318024.4_Intron|USH1C_ENST00000527720.1_Intron|USH1C_ENST00000527020.1_Intron|USH1C_ENST00000529563.1_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	0					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						AGTCTTGGGGGGATAGTAGAA	0.627000													6	20					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43507420	43507420	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43507420G>A	ENST00000300215.3	-	3	850	c.393C>T	c.(391-393)tcC>tcT	p.S131S	EPB42_ENST00000441366.2_Silent_p.S101S|EPB42_ENST00000540029.1_Intron			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	101					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		AGATGGTCCAGGACTGGGCAT	0.567000													31	76					0	0	1	0	0
VPS54	51542	broad.mit.edu	37	2	64139739	64139739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:64139739G>A	ENST00000354504.3	-	16	2609	c.2020C>T	c.(2020-2022)Cat>Tat	p.H674Y	VPS54_ENST00000409558.3_Missense_Mutation_p.H815Y|VPS54_ENST00000272322.4_Missense_Mutation_p.H827Y			Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	827					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						GCTTCAAAATGAGCCCGGATC	0.358000													9	101					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21548263	21548263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21548263G>A	ENST00000415912.2	-	18	2190	c.2065C>T	c.(2065-2067)Ctc>Ttc	p.L689F	ECE1_ENST00000436918.2_Intron|ECE1_ENST00000264205.6_Missense_Mutation_p.L702F|ECE1_ENST00000374893.6_Missense_Mutation_p.L705F|ECE1_ENST00000357071.4_Missense_Mutation_p.L693F	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	705					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		AGGAAGAAGAGCTGGTTATTG	0.532000													84	231					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711233	41711233	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41711233C>T	ENST00000400454.1	-	7	1797	c.1320G>A	c.(1318-1320)tgG>tgA	p.W440*		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	440	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CGTCCAGGGTCCACGTGATCG	0.537000													15	36					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49726605	49726605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:49726605G>A	ENST00000451037.2	-	6	1512	c.572C>T	c.(571-573)tCa>tTa	p.S191L	CA10_ENST00000442502.2_Missense_Mutation_p.S191L|CA10_ENST00000340813.6_Missense_Mutation_p.S197L|CA10_ENST00000570565.1_Missense_Mutation_p.S116L|CA10_ENST00000285273.4_Missense_Mutation_p.S191L|CA10_ENST00000571918.1_5'UTR	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	191					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGGGTTTGATGAATCAGAAAC	0.358000													26	60					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100126096	100126096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100126096C>T	ENST00000394899.2	-	8	1182	c.1089G>A	c.(1087-1089)atG>atA	p.M363I	RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000407820.2_Missense_Mutation_p.M154I|ADH6_ENST00000394897.1_3'UTR|ADH6_ENST00000237653.7_Missense_Mutation_p.M363I	NM_001102470.1	NP_001095940.1	P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	363					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TTCCAGTTTTCATTAATTCAA	0.373000													31	56					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735244	13735244	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13735244A>G	ENST00000265104.4	-	68	11861	c.11757T>C	c.(11755-11757)atT>atC	p.I3919I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3919					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATTGACCTTTAATAAGAGTGA	0.413000									Kartagener syndrome				18	47					0	0	1	0	0
WDR93	56964	broad.mit.edu	37	15	90276307	90276307	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90276307C>T	ENST00000268130.7	+	13	1502	c.1401C>T	c.(1399-1401)ttC>ttT	p.F467F	WDR93_ENST00000560294.1_Intron|WDR93_ENST00000444934.2_Silent_p.F184F	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	467					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			TAAAATATTTCTCGGTCCACA	0.483000													15	207					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38950520	38950520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38950520C>T	ENST00000302328.3	-	9	1465	c.1267G>A	c.(1267-1269)Gaa>Aaa	p.E423K	SCN11A_ENST00000456224.3_Missense_Mutation_p.E423K|SCN11A_ENST00000444237.2_Missense_Mutation_p.E423K|SCN11A_ENST00000450244.1_Missense_Mutation_p.E423K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	423					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGCTGGGCTTCCTGAAACATC	0.512000													60	174					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582563	82582563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82582563G>A	ENST00000423517.2	-	5	8043	c.7706C>T	c.(7705-7707)tCa>tTa	p.S2569L	PCLO_ENST00000333891.8_Missense_Mutation_p.S2569L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2500					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AAATCTTGGTGAAGACTTGTT	0.403000													48	131					0	0	1	0	0
ADRA2B	151	broad.mit.edu	37	2	96780804	96780804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96780804C>T	ENST00000409345.3	-	1	1180	c.1085G>A	c.(1084-1086)cGg>cAg	p.R362Q		NM_000682.5	NP_000673.2	P18089	ADA2B_HUMAN	adrenoceptor alpha 2B	365				QL -> HV (in Ref. 1 and 2).	activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GCGCTTCTCCCGGGTCAGCTG	0.657000													6	32					0	0	1	0	0
SLAMF7	57823	broad.mit.edu	37	1	160719870	160719870	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160719870G>A	ENST00000368043.3	+	3	673	c.636G>A	c.(634-636)agG>agA	p.R212R	SLAMF7_ENST00000441662.2_Intron|SLAMF7_ENST00000458602.2_Silent_p.R105R|SLAMF7_ENST00000458104.2_Silent_p.R105R|SLAMF7_ENST00000444090.2_Intron|SLAMF7_ENST00000368042.3_Silent_p.R105R|SLAMF7_ENST00000359331.4_Silent_p.R212R	NM_021181.3	NP_067004.3	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	212					cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TCCTTGCCAGGAAGCTCTGTG	0.557000													30	82					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121708823	121708823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:121708823C>T	ENST00000452319.1	+	4	319	c.259C>T	c.(259-261)Cct>Tct	p.P87S	GLI2_ENST00000361492.4_Missense_Mutation_p.P87S|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000314490.11_5'UTR			P10070	GLI2_HUMAN	GLI family zinc finger 2	87					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CTGCAGGCCCCCTGCCCTCAG	0.632000													36	236					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39331902	39331902	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39331902C>T	ENST00000263408.4	-	5	586	c.491G>A	c.(490-492)gGg>gAg	p.G164E	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	164	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GGGATCCATCCCTAAAATGTT	0.458000													12	165					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95263154	95263154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95263154C>T	ENST00000344604.5	-	9	1935	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	CENPP_ENST00000375587.3_Intron|ECM2_ENST00000444490.2_Missense_Mutation_p.D574N	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	596					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						TCCATGCCATCATCAGCAAGT	0.443000													25	94					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171766709	171766709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:171766709G>A	ENST00000311601.5	-	13	1570	c.1400C>T	c.(1399-1401)tCc>tTc	p.S467F	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	467					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGGGGCCGGGAGGGGCCCGT	0.642000													15	39					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139909534	139909534	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139909534G>A	ENST00000265662.5	-	25	3860	c.3713C>T	c.(3712-3714)tCc>tTc	p.S1238F	ABCA2_ENST00000371605.3_Missense_Mutation_p.S1237F|ABCA2_ENST00000341511.6_Missense_Mutation_p.S1238F			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1237					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGGGGGGCTGGATGCCAGCCC	0.642000													16	31					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159707595	159707595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:159707595G>A	ENST00000393977.3	-	3	502	c.217C>T	c.(217-219)Cgc>Tgc	p.R73C	CCNJL_ENST00000541762.1_Missense_Mutation_p.R72C|CCNJL_ENST00000257536.7_Missense_Mutation_p.R73C|CCNJL_ENST00000519673.1_Missense_Mutation_p.R73C|CCNJL_ENST00000377503.2_5'UTR|CCNJL_ENST00000505287.2_Missense_Mutation_p.R118C	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	73	Cyclin N-terminal.					nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACGTTGTAGCGATCCATGAAG	0.617000													17	73					0	0	1	0	0
PAFAH2	5051	broad.mit.edu	37	1	26311004	26311004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26311004G>A	ENST00000374282.3	-	5	536	c.357C>T	c.(355-357)gcC>gcT	p.A119A	PAFAH2_ENST00000374284.1_Silent_p.A119A|PAFAH2_ENST00000493892.1_5'UTR	NM_000437.3	NP_000428.2	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2, 40kDa	119					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			NS(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|urinary_tract(1)	9		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		CCATGCAGAAGGCTGAATACA	0.527000													11	34					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94693326	94693326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94693326G>A	ENST00000282020.4	+	16	2959	c.2701G>A	c.(2701-2703)Gat>Aat	p.D901N	GRID2_ENST00000510992.1_Missense_Mutation_p.D806N	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	901					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTCGTCAATTGATTTGACCCC	0.458000													11	181					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207135708	207135708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207135708C>T	ENST00000324852.4	-	5	976	c.502G>A	c.(502-504)Gac>Aac	p.D168N	FCAMR_ENST00000450945.2_Missense_Mutation_p.D168N|FCAMR_ENST00000400962.3_Missense_Mutation_p.D168N	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	123	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						GCCACACGGTCACGATAGCGA	0.572000													24	51					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249913	52249913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52249913C>T	ENST00000595042.1	-	3	476	c.335G>A	c.(334-336)aGt>aAt	p.S112N	FPR1_ENST00000304748.4_Missense_Mutation_p.S112N	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	112					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CAGGAAGACACTTCCGAACAA	0.547000													21	69					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148384332	148384332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148384332G>A	ENST00000515425.1	-	17	3910	c.3809C>T	c.(3808-3810)cCc>cTc	p.P1270L	SH3TC2_ENST00000538184.1_3'UTR|SH3TC2_ENST00000512049.1_Missense_Mutation_p.P1263L|SH3TC2_ENST00000502274.1_Missense_Mutation_p.P132L	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1270							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACCCGGAGGGCCTGCTGTG	0.642000													9	23					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202161	56202161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56202161G>A	ENST00000361673.3	-	5	5471	c.5258C>T	c.(5257-5259)gCc>gTc	p.A1753V		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1753							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTTAAGAAAGGCTGAGTTCTT	0.408000													45	119					0	0	1	0	0
NGDN	25983	broad.mit.edu	37	14	23944473	23944473	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23944473C>T	ENST00000397154.3	+	4	251	c.238C>T	c.(238-240)Ctt>Ttt	p.L80F	NGDN_ENST00000408901.3_Missense_Mutation_p.L80F			Q8NEJ9	NGDN_HUMAN	neuroguidin, EIF4E binding protein	80	Necessary for interaction with EIF4E (By similarity).				regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus		p.L80V(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	12	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		AGGAGGATCTCTTCAGGGACA	0.468000													41	69					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64675261	64675261	+	Silent	SNP	G	G	A	rs112442396		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64675261G>A	ENST00000421419.2	-	17	2580	c.2466C>T	c.(2464-2466)atC>atT	p.I822I	ATG2A_ENST00000377264.3_Silent_p.I822I			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	822							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						TGGGCAGAAAGATGTGGACAC	0.632000													7	24					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27458130	27458130	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27458130C>T	ENST00000264705.4	+	24	3966	c.3804C>T	c.(3802-3804)ttC>ttT	p.F1268F	CAD_ENST00000403525.1_Silent_p.F1205F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1268	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AGTTCTCCTTCTCCCGCTTGG	0.617000													9	76					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26219491	26219491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26219491G>A	ENST00000335473.7	+	13	2791	c.2541G>A	c.(2539-2541)atG>atA	p.M847I	MYO18B_ENST00000536101.1_Missense_Mutation_p.M847I|MYO18B_ENST00000407587.2_Missense_Mutation_p.M847I	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	847	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGCAGTTCATGAGGTTTGAGT	0.577000													22	52					0	0	1	0	0
LRIF1	55791	broad.mit.edu	37	1	111494481	111494481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111494481G>A	ENST00000369763.4	-	2	1415	c.1025C>T	c.(1024-1026)cCt>cTt	p.P342L	LRIF1_ENST00000485275.2_Intron|RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000494675.1_Intron	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						CGTCCCACTAGGATCGATGGT	0.343000													42	141					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43299342	43299342	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43299342G>A	ENST00000290650.4	-	30	3428	c.3350C>T	c.(3349-3351)tCg>tTg	p.S1117L	UBR1_ENST00000382177.2_3'UTR|UBR1_ENST00000568782.1_5'UTR	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	1117					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GACACAGGCCGATAATACCAT	0.423000													40	120					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51562358	51562358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:51562358G>A	ENST00000298239.6	+	3	229	c.197G>A	c.(196-198)aGg>aAg	p.R66K	MSMB_ENST00000358559.2_Silent_p.K101K	NM_138634.2	NP_619540.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	0						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						TGGAGAAGAAGGACCCAAAAA	0.468000													18	169					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46916050	46916050	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46916050C>T	ENST00000307522.3	-	1	791	c.18G>A	c.(16-18)gaG>gaA	p.E6E		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	6						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		agtcgacgtcctccccgatct	0.602000													8	46					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41318429	41318429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41318429C>T	ENST00000551295.2	+	6	588	c.471C>T	c.(469-471)ctC>ctT	p.L157L	CNTN1_ENST00000547849.1_Silent_p.L157L|CNTN1_ENST00000547702.1_Silent_p.L157L|CNTN1_ENST00000348761.2_Silent_p.L146L|CNTN1_ENST00000360099.3_Silent_p.L157L|CNTN1_ENST00000347616.1_Silent_p.L157L	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	157	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGGTGCTTCTCTGTGACCCCC	0.378000													13	46					0	0	1	0	0
UNC45A	55898	broad.mit.edu	37	15	91492021	91492021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91492021C>T	ENST00000394275.2	+	16	2665	c.1830C>T	c.(1828-1830)ccC>ccT	p.P610P	UNC45A_ENST00000418476.2_Silent_p.P625P	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	625					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGCAGCACCCCAAGGTGAGGG	0.577000													8	17					0	0	1	0	0
DSPP	1834	broad.mit.edu	37	4	88534406	88534406	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88534406A>T	ENST00000399271.1	+	4	1188	c.1068A>T	c.(1066-1068)gaA>gaT	p.E356D	RP11-742B18.1_ENST00000506480.1_RNA|DSPP_ENST00000282478.7_Missense_Mutation_p.E356D	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	356					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		AACGCGTAGAAAATAGAATCA	0.413000													19	44					0	0	1	0	0
TSC22D1	8848	broad.mit.edu	37	13	45149450	45149450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:45149450G>A	ENST00000458659.2	-	1	1251	c.761C>T	c.(760-762)cCc>cTc	p.P254L	TSC22D1_ENST00000501704.2_Missense_Mutation_p.P254L	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	254					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TGGGCTTGAGGGTGGCCCACC	0.507000													23	48					0	0	1	0	0
OR1D5	8386	broad.mit.edu	37	17	2966227	2966227	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:2966227G>A	ENST00000575751.1	-	1	674	c.675C>T	c.(673-675)atC>atT	p.I225I		NM_014566.1	NP_055381.1	P58170	OR1D5_HUMAN	olfactory receptor, family 1, subfamily D, member 5	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|lung(10)	11						GCATTTGAAGGATGGTTCTGA	0.493000													10	26					0	0	1	0	0
MAX	4149	broad.mit.edu	37	14	65544090	65544090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65544090G>A	ENST00000557277.1	-	5	497	c.78C>T	c.(76-78)tcC>tcT	p.S26S	MAX_ENST00000555419.1_Intron|MAX_ENST00000284165.6_3'UTR|MAX_ENST00000555667.1_3'UTR|MAX_ENST00000358402.4_Intron|MAX_ENST00000556979.1_3'UTR|MAX_ENST00000555932.1_Intron|MAX_ENST00000358664.4_Intron|MAX_ENST00000341653.2_Intron			P61244	MAX_HUMAN	MYC associated factor X	0					transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		CTTCCATGAGGGAGGAAGAGA	0.413000													19	54					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122809232	122809232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122809232C>T	ENST00000194130.2	-	4	562	c.523G>A	c.(523-525)Gga>Aga	p.G175R	SLC13A1_ENST00000539873.1_Missense_Mutation_p.G111R	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	175						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TTGGTTGATCCGTTGAAGTAA	0.473000													14	45					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42368140	42368140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:42368140G>A	ENST00000298119.4	+	5	3308	c.2119G>A	c.(2119-2121)Gac>Aac	p.D707N	LRFN5_ENST00000554120.1_Intron|LRFN5_ENST00000554171.1_3'UTR	NM_152447.3	NP_689660.2	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	707						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GACTAATGTTGACCAGATTGT	0.284000										HNSCC(30;0.082)			19	132					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903240	6903240	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:6903240C>T	ENST00000486284.1	+	1	439	c.165C>T	c.(163-165)ttC>ttT	p.F55F	GRM7_ENST00000403881.1_Silent_p.F55F|GRM7_ENST00000389336.4_Silent_p.F55F|GRM7_ENST00000402647.2_Silent_p.F55F|GRM7_ENST00000357716.4_Silent_p.F55F	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	55					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GGGGGCTGTTCCCCGTGCACG	0.692000													3	9					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28229733	28229733	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28229733A>G	ENST00000305242.5	-	13	1837	c.1743_splice	c.e13-1	p.V582_splice	ARMC4_ENST00000537576.1_Splice_Site_p.V274_splice|ARMC4_ENST00000545014.1_Splice_Site_p.V107_splice	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	582							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TAGTAGAGCAACCTATAATAA	0.448000													33	65					0	0	1	0	0
TRBV7-8	28590	broad.mit.edu	37	7	142099651	142099651	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142099651G>A	ENST00000390359.3	-	0	189																											TACCAAAAAAGGGATACATGA	0.517000													11	44					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125769852	125769852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:125769852G>A	ENST00000346248.5	-	8	2141	c.1499C>T	c.(1498-1500)cCc>cTc	p.P500L	CHST15_ENST00000435907.1_Missense_Mutation_p.P500L	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	500					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						CTCACTTAAGGGCCCTAGAAT	0.547000													5	4					0	0	1	0	0
RAB3D	9545	broad.mit.edu	37	19	11448054	11448054	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11448054G>A	ENST00000222120.3	-	2	282	c.22C>T	c.(22-24)Cag>Tag	p.Q8*	RAB3D_ENST00000589655.1_Nonsense_Mutation_p.Q8*	NM_004283.3	NP_004274.1	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	8					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|ovary(2)	14						GGGCCTGCCTGGGTGTCTCCA	0.557000													39	104					0	0	1	0	0
KCND1	3750	broad.mit.edu	37	X	48826306	48826306	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48826306G>A	ENST00000218176.3	-	1	1670	c.373C>T	c.(373-375)Ccc>Tcc	p.P125S		NM_004979.4	NP_004970.3	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 1	125						voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	24						ACTAGCTCGGGAACCAGGCCG	0.622000													12	8					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130293171	130293171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130293171G>A	ENST00000358511.6	+	7	3380	c.3349G>A	c.(3349-3351)Gag>Aag	p.E1117K	COL6A6_ENST00000453409.2_Missense_Mutation_p.E1117K	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1117	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GTCCCAAGACGAGGTGGCCCA	0.577000													18	59					0	0	1	0	0
DYDC2	84332	broad.mit.edu	37	10	82122300	82122300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:82122300C>T	ENST00000372199.1	+	4	699	c.101C>T	c.(100-102)gCt>gTt	p.A34V	DYDC2_ENST00000256039.2_Missense_Mutation_p.A34V|DYDC2_ENST00000372198.1_Missense_Mutation_p.A48V|DYDC2_ENST00000444807.2_Missense_Mutation_p.A34V|DYDC2_ENST00000372197.1_Missense_Mutation_p.A34V			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	34							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			GAATACCTGGCTCACTGGCTT	0.498000													13	58					0	0	1	0	0
NDUFS2	4720	broad.mit.edu	37	1	161180451	161180451	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161180451C>T	ENST00000392179.4	+	9	1176	c.937C>T	c.(937-939)Cag>Tag	p.Q313*	NDUFS2_ENST00000476409.2_Nonsense_Mutation_p.Q215*|NDUFS2_ENST00000465923.1_3'UTR|NDUFS2_ENST00000367993.3_Nonsense_Mutation_p.Q313*	NM_001166159.1	NP_001159631.1	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	313					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	18	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	TGTTTACGACCAGGTTGAGTT	0.527000													13	49					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839532	27839532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27839532G>A	ENST00000356790.2	+	3	354	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	37								p.E37*(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AGAGGAGGAAGAATCTCCCCC	0.517000													19	17					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108216912	108216912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108216912G>A	ENST00000273353.3	-	7	721	c.665C>T	c.(664-666)tCc>tTc	p.S222F		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	222	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTTTTTCCTGGATTCAATCAT	0.433000													25	164					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56058019	56058019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56058019G>A	ENST00000313022.2	-	1	547	c.520C>T	c.(520-522)Cgt>Tgt	p.R174C		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					AAAAAGTGACGAACTACATTT	0.438000													30	77					0	0	1	0	0
ZNF141	7700	broad.mit.edu	37	4	367194	367194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:367194C>T	ENST00000240499.7	+	4	1117	c.968C>T	c.(967-969)tCc>tTc	p.S323F	ZNF141_ENST00000512994.1_Intron|ZNF141_ENST00000505939.1_Intron	NM_003441.2	NP_003432.1	Q15928	ZN141_HUMAN	zinc finger protein 141	323					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	18						TTTAATAGGTCCACAACCCTT	0.378000													36	101					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45709910	45709910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45709910C>T	ENST00000291582.5	+	7	965	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	280	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		GGGCAGCGTTCCCGCCCCTCT	0.687000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				7	19					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103180703	103180703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103180703G>A	ENST00000424685.2	-	44	7030	c.6871C>T	c.(6871-6873)Ctt>Ttt	p.L2291F	RELN_ENST00000343529.5_Missense_Mutation_p.L2291F|RELN_ENST00000428762.1_Missense_Mutation_p.L2291F			P78509	RELN_HUMAN	reelin	2291					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.L2291F(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACCAGCGAAGGCGAGTAGAA	0.498000													34	94					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236898958	236898958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236898958G>A	ENST00000366578.4	+	8	887	c.721G>A	c.(721-723)Gat>Aat	p.D241N	ACTN2_ENST00000542672.1_Intron|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_Intron	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	241	Actin-binding.|CH 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CCCTAAACCCGATGAAAGAGC	0.537000													21	64					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48528861	48528861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48528861C>T	ENST00000435803.1	+	48	13235	c.13211C>T	c.(13210-13212)tCc>tTc	p.S4404F	ABCA13_ENST00000544596.1_Missense_Mutation_p.S134F	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4404					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGTTTTCATTCCCTACCTTCC	0.378000													10	21					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19335212	19335212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19335212G>A	ENST00000252575.5	+	5	791	c.748G>A	c.(748-750)Gat>Aat	p.D250N		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	250	Link 1.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GGAACTCTACGATGTGTATTG	0.592000													27	97					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63447955	63447955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:63447955G>A	ENST00000322893.7	-	6	845	c.577C>T	c.(577-579)Cct>Tct	p.P193S	KCNH5_ENST00000420622.2_Missense_Mutation_p.P193S|KCNH5_ENST00000394968.1_Missense_Mutation_p.P135S|KCNH5_ENST00000394964.2_Missense_Mutation_p.P135S	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	193					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTATACTGAGGAAGGATATCT	0.358000													28	48					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179590249	179590249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179590249C>T	ENST00000589042.1	-	71	20906	c.20682G>A	c.(20680-20682)gtG>gtA	p.V6894V	TTN_ENST00000342992.6_Silent_p.V5650V|TTN_ENST00000591111.1_Silent_p.V6577V|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|RP11-171I2.1_ENST00000590024.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6577	Ig-like 50.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTCTAATCACTTCTTCCT	0.438000													24	59					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73474816	73474816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73474816C>T	ENST00000252034.7	+	25	2131	c.1732C>T	c.(1732-1734)Cct>Tct	p.P578S	ELN_ENST00000380576.5_Missense_Mutation_p.P559S|ELN_ENST00000458204.1_Missense_Mutation_p.P568S|ELN_ENST00000380575.4_Missense_Mutation_p.P549S|ELN_ENST00000320492.7_Missense_Mutation_p.P497S|ELN_ENST00000414324.1_Missense_Mutation_p.P554S|ELN_ENST00000380553.4_Missense_Mutation_p.P442S|ELN_ENST00000357036.5_Missense_Mutation_p.P583S|ELN_ENST00000429192.1_Missense_Mutation_p.P564S|ELN_ENST00000380584.4_Missense_Mutation_p.P530S|ELN_ENST00000358929.4_Missense_Mutation_p.P613S|ELN_ENST00000445912.1_Missense_Mutation_p.P578S|ELN_ENST00000380562.4_Missense_Mutation_p.P584S|CTB-51J22.1_ENST00000435932.1_RNA|ELN_ENST00000320399.6_Missense_Mutation_p.P578S	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	607	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGCTGGTGTTCCTGGCTTCGG	0.627000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						27	52					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3102809	3102809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3102809C>T	ENST00000378398.3	+	2	240	c.158C>T	c.(157-159)cCc>cTc	p.P53L	PRDM16_ENST00000378391.2_Missense_Mutation_p.P53L|PRDM16_ENST00000442529.2_Missense_Mutation_p.P53L|PRDM16_ENST00000441472.2_Missense_Mutation_p.P53L|PRDM16_ENST00000514189.1_Missense_Mutation_p.P53L|PRDM16_ENST00000511072.1_Missense_Mutation_p.P53L|PRDM16_ENST00000270722.5_Missense_Mutation_p.P53L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	53					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCACCGTCCCCCTTCCCCACC	0.647000			T	EVI1	"""MDS, AML"""								13	102					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10452333	10452333	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10452333G>A	ENST00000397077.1	-	5	941	c.366C>T	c.(364-366)tcC>tcT	p.S122S	ATP2B2_ENST00000383800.4_Silent_p.S122S|ATP2B2_ENST00000360273.2_Silent_p.S122S|ATP2B2_ENST00000352432.4_Silent_p.S122S|ATP2B2_ENST00000343816.4_Silent_p.S122S			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	122					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GGTGGTAGAAGGACAGCCCCA	0.642000													74	215					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904562	55904562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55904562C>T	ENST00000301529.1	-	1	632	c.633G>A	c.(631-633)atG>atA	p.M211I		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M211I(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					GAACTGTAATCATGGAAAAAA	0.358000													15	85					0	0	1	0	0
SLC35B3	51000	broad.mit.edu	37	6	8422706	8422706	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:8422706G>A	ENST00000379660.4	-	5	1020	c.571C>T	c.(571-573)Caa>Taa	p.Q191*	SLC35B3_ENST00000339306.5_Nonsense_Mutation_p.Q191*	NM_001142540.1|NM_001142541.1|NM_015948.3	NP_001136012.1|NP_001136013.1|NP_057032.2	Q9H1N7	S35B3_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3	191					transmembrane transport	Golgi membrane|integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(1)|prostate(1)	15	Ovarian(93;0.0569)					ACTATACCTTGAATAAAAACT	0.333000													12	54					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113679953	113679953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113679953G>A	ENST00000003302.4	-	17	2064	c.1996C>T	c.(1996-1998)Caa>Taa	p.Q666*	USP28_ENST00000545540.1_Nonsense_Mutation_p.Q541*|USP28_ENST00000544967.1_Nonsense_Mutation_p.Q374*|USP28_ENST00000260188.5_Nonsense_Mutation_p.Q666*	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	666					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCTGACATTTGATCTGATTCA	0.438000													124	311					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127958729	127958729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:127958729G>A	ENST00000335247.7	-	3	487	c.357C>T	c.(355-357)ttC>ttT	p.F119F	CYP27C1_ENST00000409327.1_Silent_p.F119F	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	119						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		AGGACCTGCAGAATTCCCGCC	0.522000													12	187					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69107480	69107480	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69107480C>T	ENST00000332644.5	-	2	212	c.51G>A	c.(49-51)acG>acA	p.T17T		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	17					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity	p.T17T(2)		breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						AAATAAAGATCGTAGTCCATA	0.388000													36	49					0	0	1	0	0
USP46	64854	broad.mit.edu	37	4	53476724	53476724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:53476724G>A	ENST00000441222.2	-	5	805	c.621C>T	c.(619-621)tcC>tcT	p.S207S	USP46_ENST00000451218.2_Silent_p.S180S|USP46_ENST00000508499.1_Silent_p.S200S	NM_022832.3	NP_073743.2	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46	207					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)	12			LUSC - Lung squamous cell carcinoma(32;0.0295)			AGTGGGTAATGGATGTATTCT	0.363000													15	31					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35954365	35954365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35954365C>T	ENST00000274278.3	-	7	1868	c.1511G>A	c.(1510-1512)gGg>gAg	p.G504E		NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	504						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAGCAGCTTCCCACAAAGCCA	0.587000													22	49					0	0	1	0	0
MPV17	4358	broad.mit.edu	37	2	27532804	27532804	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27532804C>A	ENST00000402310.1	-	7	461	c.454G>T	c.(454-456)Gtc>Ttc	p.V152F	MPV17_ENST00000357186.6_Silent_p.L113L|MPV17_ENST00000233545.2_Silent_p.L169L|MPV17_ENST00000402722.1_3'UTR|MPV17_ENST00000380044.1_Silent_p.L169L|MPV17_ENST00000405983.1_Silent_p.L184L|MPV17_ENST00000405076.1_Silent_p.L106L			P39210	MPV17_HUMAN	MpV17 mitochondrial inner membrane protein	0					cellular response to reactive oxygen species|glomerular basement membrane development|homeostatic process|inner ear development|mitochondrial genome maintenance|regulation of reactive oxygen species metabolic process	integral to peroxisomal membrane|mitochondrial inner membrane				lung(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTCCAGGACAGGTAGGAGT	0.517000													13	36					0.00010058	0.000100728	1	1	0
ADAM23	8745	broad.mit.edu	37	2	207429762	207429762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207429762C>T	ENST00000264377.3	+	14	1692	c.1364C>T	c.(1363-1365)tCc>tTc	p.S455F	ADAM23_ENST00000374416.1_Missense_Mutation_p.S455F|ADAM23_ENST00000374415.3_Missense_Mutation_p.S455F	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	455	Peptidase M12B.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TGCACAGAATCCTGGGGTGGC	0.363000													34	101					0	0	1	0	0
ACSL6	23305	broad.mit.edu	37	5	131308971	131308971	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131308971C>T	ENST00000379264.2	-	12	1299	c.1191G>A	c.(1189-1191)cgG>cgA	p.R397R	ACSL6_ENST00000357096.1_Silent_p.R297R|ACSL6_ENST00000379255.1_Silent_p.R297R|ACSL6_ENST00000544770.1_Silent_p.R281R|ACSL6_ENST00000431707.1_Silent_p.R352R|ACSL6_ENST00000379249.3_Silent_p.R372R|ACSL6_ENST00000379240.1_Silent_p.R372R|ACSL6_ENST00000379244.1_Silent_p.R372R|ACSL6_ENST00000379246.1_Silent_p.R383R|ACSL6_ENST00000296869.4_Silent_p.R397R|ACSL6_ENST00000543479.1_Silent_p.R372R|ACSL6_ENST00000379272.2_Silent_p.R387R	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	372					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGTCGTACATCCGGTTCAGCA	0.562000													22	68					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192700856	192700856	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:192700856C>T	ENST00000304141.4	-	2	1400	c.1071G>A	c.(1069-1071)gaG>gaA	p.E357E		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	357						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	AGGTCGCCTTCTCAGCAGCCT	0.572000													13	165					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409322	59409322	+	Missense_Mutation	SNP	C	C	T	rs150039957	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:59409322C>T	ENST00000301645.3	-	3	886	c.749G>A	c.(748-750)aGg>aAg	p.R250K		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	250					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GATGCTTTCCCTCTTTTGGAG	0.542000									Neonatal Giant Cell Hepatitis				31	224					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49000670	49000670	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49000670C>T	ENST00000600059.1	-	11	3883	c.3656G>A	c.(3655-3657)gGg>gAg	p.G1219E	LMTK3_ENST00000270238.3_Missense_Mutation_p.G1248E					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTCGCTGTTCCCCTGAGGGGG	0.652000													22	50					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165386283	165386283	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165386283C>T	ENST00000359842.5	-	4	919	c.617G>A	c.(616-618)aGg>aAg	p.R206K	RXRG_ENST00000470566.1_5'UTR	NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	206	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CTCACCTTCCCTCTTCATGCC	0.512000													14	59					0	0	1	0	0
RPLP0P6	220717	broad.mit.edu	37	2	38708951	38708951	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:38708951C>T	ENST00000417039.1	-	0	696																											GAAGTGACATCGTCTTTAAAC	0.552000													5	14					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160732029	160732029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160732029C>T	ENST00000263636.4	-	12	1927	c.1900G>A	c.(1900-1902)Gaa>Aaa	p.E634K	LY75-CD302_ENST00000504764.1_Missense_Mutation_p.E634K|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.E634K|LY75_ENST00000553424.1_Missense_Mutation_p.E634K|LY75_ENST00000554112.1_Missense_Mutation_p.E634K	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		GGGGATGCTTCTTCAGGCCCA	0.473000													49	160					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94083536	94083536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94083536C>T	ENST00000553484.1	+	29	4330	c.4176C>T	c.(4174-4176)tgC>tgT	p.C1392C	UNC79_ENST00000555664.1_Silent_p.C1370C|UNC79_ENST00000256339.4_Silent_p.C1193C|UNC79_ENST00000393151.2_Silent_p.C1370C			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1370						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TCAAATACTGCTCTTGTCCTC	0.453000													40	102					0	0	1	0	0
TTLL2	83887	broad.mit.edu	37	6	167754223	167754223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:167754223C>T	ENST00000239587.5	+	3	923	c.835C>T	c.(835-837)Cgg>Tgg	p.R279W		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	279	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		AGGGTTGGTTCGGTTTGCCAC	0.398000													78	119					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909307	123909307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123909307C>T	ENST00000330487.5	-	1	410	c.402G>A	c.(400-402)atG>atA	p.M134I		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GCCCAGTCATCATGTTGGTGT	0.542000													67	206					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33552743	33552743	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:33552743G>A	ENST00000265371.4	-	5	1014	c.489C>T	c.(487-489)ttC>ttT	p.F163F	NRP1_ENST00000395995.1_Silent_p.F163F|NRP1_ENST00000374867.2_Silent_p.F163F|NRP1_ENST00000374822.4_Silent_p.F163F|NRP1_ENST00000374821.5_Silent_p.F163F|NRP1_ENST00000374823.5_Silent_p.F163F|NRP1_ENST00000374816.3_Silent_p.F163F			O14786	NRP1_HUMAN	neuropilin 1	163	CUB 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	ATTTTTCAGGGAATCCGGGGG	0.423000													67	226					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78073340	78073340	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78073340C>T	ENST00000397545.4	+	20	3222	c.3195C>T	c.(3193-3195)atC>atT	p.I1065I		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1065					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TTTCAGAGATCGTGGCCCTGC	0.562000													21	59					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124438117	124438117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124438117G>A	ENST00000360013.3	+	60	8888	c.8761G>A	c.(8761-8763)Gaa>Aaa	p.E2921K	KALRN_ENST00000428018.2_Missense_Mutation_p.E1192K|KALRN_ENST00000291478.4_Missense_Mutation_p.E1224K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2920	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.E2921*(1)|p.E1224*(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GATCTTACAGGAAGATTTTCG	0.522000													12	64					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28865888	28865888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:28865888G>A	ENST00000422425.2	+	57	4349	c.4305G>A	c.(4303-4305)agG>agA	p.R1435R	PLB1_ENST00000541605.1_Silent_p.R411R|PLB1_ENST00000327757.5_Silent_p.R1446R|AC074011.2_ENST00000431376.1_RNA	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1446	Necessary for membrane localization (By similarity).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GTGGCCGGAGGGAAGATCCTC	0.652000													6	6					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53839063	53839063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53839063G>A	ENST00000288139.3	+	46	5817	c.5699G>A	c.(5698-5700)aGg>aAg	p.R1900K	CACNA1D_ENST00000422281.2_Missense_Mutation_p.R1856K|CACNA1D_ENST00000544977.1_Missense_Mutation_p.R259K|CACNA1D_ENST00000350061.5_Missense_Mutation_p.R1880K	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1880					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GACTCTGAGAGGCCCCGAGGC	0.537000													23	113					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20482730	20482730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20482730G>A	ENST00000305045.2	-	1	622	c.623C>T	c.(622-624)tCc>tTc	p.S208F		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ACAGCTCAAGGAAAGCAACCC	0.507000													20	38					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145629432	145629432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:145629432G>A	ENST00000296575.3	+	7	1925	c.1270G>A	c.(1270-1272)Gtg>Atg	p.V424M		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	424						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GCCCCCCGAAGTGTTTGCTCA	0.532000													16	69					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43594307	43594307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43594307G>A	ENST00000395891.1	+	29	5232	c.4627G>A	c.(4627-4629)Gaa>Aaa	p.E1543K	HECW1_ENST00000453890.1_Missense_Mutation_p.E1509K	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1543	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.E1522Q(1)		NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CGTGCCCTACGAAGGCTTCGC	0.562000													9	35					0	0	1	0	0
FAM26D	221301	broad.mit.edu	37	6	116879329	116879329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116879329G>A	ENST00000368596.3	+	2	944	c.900G>A	c.(898-900)gaG>gaA	p.E300E	FAM26D_ENST00000416171.2_Silent_p.E156E|FAM26D_ENST00000368597.2_Silent_p.E114E|FAM26D_ENST00000405399.1_Silent_p.E157E			Q5JW98	FA26D_HUMAN	family with sequence similarity 26, member D	300						integral to membrane				endometrium(1)|lung(5)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0458)|OV - Ovarian serous cystadenocarcinoma(136;0.0694)|Epithelial(106;0.222)		GGGTGGATGAGGATAATGAGG	0.408000													16	62					0	0	1	0	0
B3GALNT1	8706	broad.mit.edu	37	3	160803840	160803840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:160803840G>A	ENST00000392781.2	-	8	1450	c.703C>T	c.(703-705)Cct>Tct	p.P235S	B3GALNT1_ENST00000392779.2_Missense_Mutation_p.P235S|B3GALNT1_ENST00000473285.1_Missense_Mutation_p.P235S|B3GALNT1_ENST00000488170.1_Missense_Mutation_p.P235S|B3GALNT1_ENST00000392780.1_Missense_Mutation_p.P235S|B3GALNT1_ENST00000320474.4_Missense_Mutation_p.P235S|B3GALNT1_ENST00000417187.1_Intron	NM_001038628.1	NP_001033717.1	O75752	B3GL1_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	235					protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			CAGTATGGAGGGAACACCTTG	0.378000													25	74					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86813153	86813153	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86813153C>T	ENST00000441037.2	+	13	1799	c.1704C>T	c.(1702-1704)ttC>ttT	p.F568F	AGBL1_ENST00000389298.3_Silent_p.F299F|AGBL1_ENST00000421325.2_Silent_p.F568F	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	568					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding	p.F568F(1)		NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TCTGCAGGTTCGAGTATGACT	0.473000													10	36					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923865	24923865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24923865C>T	ENST00000329468.2	+	1	3325	c.2851C>T	c.(2851-2853)Cca>Tca	p.P951S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GTTAACATCACCATATACTGC	0.478000													24	65					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54450144	54450144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54450144G>A	ENST00000566473.2	+	6	748	c.748G>A	c.(748-750)Gct>Act	p.A250T	ANKFN1_ENST00000318698.2_Missense_Mutation_p.A250T			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	250										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						GCAGCTGAAAGCTTGGGAGTG	0.498000													42	118					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90167845	90167845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90167845C>T	ENST00000268138.7	+	20	4409	c.4304C>T	c.(4303-4305)cCt>cTt	p.P1435L	KIF7_ENST00000558928.1_Intron|TICRR_ENST00000560985.1_Missense_Mutation_p.P1434L					TOPBP1-interacting checkpoint and replication regulator																		CAGTCTCCTCCTGAAAGACGG	0.582000													67	82					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20849204	20849204	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20849204G>A	ENST00000262715.5	-	33	4688	c.4647_splice	c.e33-1	p.L1550_splice	TEP1_ENST00000556935.1_Splice_Site_p.L1442_splice|TEP1_ENST00000545983.1_5'UTR	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1550					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCGCTCTGGAGCTGAGAAGGT	0.517000													9	32					0	0	1	0	0
GLRA1	2741	broad.mit.edu	37	5	151230975	151230975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:151230975G>A	ENST00000274576.4	-	7	1180	c.888C>T	c.(886-888)tcC>tcT	p.S296S	GLRA1_ENST00000455880.2_Silent_p.S296S|GLRA1_ENST00000545569.1_Silent_p.S213S|GLRA1_ENST00000471351.2_5'UTR	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	296					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTCGAGAGCCGGAGCTCTGGG	0.542000													21	44					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60348221	60348221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60348221C>T	ENST00000360469.5	+	4	647	c.559C>T	c.(559-561)Ccg>Tcg	p.P187S	CDH4_ENST00000543233.1_Missense_Mutation_p.P113S	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	187	Cadherin 1.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CGGGCCCTTCCCGCAGCAGCT	0.701000													5	4					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7254553	7254553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7254553G>A	ENST00000266542.4	-	3	523	c.431C>T	c.(430-432)tCc>tTc	p.S144F	C1RL_ENST00000545280.1_Intron|C1RL_ENST00000545337.1_Missense_Mutation_p.S144F|C1RL_ENST00000544702.1_Missense_Mutation_p.S144F	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	144	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GTTCTCCGAGGAAGGCTGTGT	0.622000													37	108					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18707512	18707512	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18707512G>A	ENST00000392386.3	-	6	1137	c.944C>T	c.(943-945)cCc>cTc	p.P315L		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	315	Fibronectin type-III 2.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						GATGCCAAAGGGGTTGCAGCG	0.637000													7	34					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058160	79058160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79058160G>A	ENST00000388820.4	-	19	4303	c.4093C>T	c.(4093-4095)Cct>Tct	p.P1365S		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1365					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GGCACCTCAGGGCTGAGGGAC	0.667000													15	22					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2161844	2161844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:2161844C>T	ENST00000382203.1	+	28	4349	c.4140C>T	c.(4138-4140)ccC>ccT	p.P1380P	SMARCA2_ENST00000382194.1_Silent_p.P1380P|SMARCA2_ENST00000349721.2_Silent_p.P1380P|SMARCA2_ENST00000382186.1_Silent_p.P44P|SMARCA2_ENST00000357248.2_Silent_p.P1380P|SMARCA2_ENST00000382185.1_Silent_p.P44P|SMARCA2_ENST00000302401.3_Silent_p.P86P|SMARCA2_ENST00000324954.5_Silent_p.P44P			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1380					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CACCAAATCCCCCCAAACTGA	0.438000													15	28					0	0	1	0	0
LINC00669	647946	broad.mit.edu	37	18	37202102	37202102	+	RNA	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:37202102T>C	ENST00000591629.1	-	0	282					NR_024391.1																						agactctaggttggatggccc	0.423000													19	60					0	0	1	0	0
TTC24	164118	broad.mit.edu	37	1	156554962	156554962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156554962G>A	ENST00000368236.3	+	8	1431	c.1395G>A	c.(1393-1395)caG>caA	p.Q465Q	TTC24_ENST00000368237.3_Silent_p.Q465Q|TTC24_ENST00000495690.1_3'UTR	NM_001105669.2	NP_001099139.2	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	465							binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	20	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGGCCACCAGAAGAAAAAAG	0.577000													20	29					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6062186	6062186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6062186C>T	ENST00000409021.3	-	11	2058	c.1609G>A	c.(1609-1611)Gaa>Aaa	p.E537K	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.E372K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.E537K|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.E352K|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.E537K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	537	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCCAAATCTTCGATTTTGGCC	0.532000													62	118					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51261219	51261219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:51261219G>A	ENST00000395542.2	-	3	497	c.313C>T	c.(313-315)Ctt>Ttt	p.L105F	COBL_ENST00000441453.1_Missense_Mutation_p.L105F|COBL_ENST00000265136.7_Missense_Mutation_p.L105F|COBL_ENST00000395540.2_Missense_Mutation_p.L105F			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	105										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CGAATTTCAAGGGCATGGTGG	0.408000													6	82					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	313576	313576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:313576G>A	ENST00000264819.4	-	8	733	c.723C>T	c.(721-723)ttC>ttT	p.F241F		NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	241	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCTGTACAGGAACTCCTCCA	0.632000													48	124					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274505	39274505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39274505C>T	ENST00000391413.2	-	1	101	c.63G>A	c.(61-63)caG>caA	p.Q21Q		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	21	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCAGGTCTCCTGGCAGAGGT	0.612000													10	29					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626345	49626345	+	Silent	SNP	C	C	T	rs140916173		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49626345C>T	ENST00000371571.4	-	2	816	c.531G>A	c.(529-531)gcG>gcA	p.A177A	RP5-955M13.4_ENST00000424566.1_RNA|KCNG1_ENST00000396017.3_Silent_p.A177A	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	177						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						CCACCATCTCCGCGAACTCCT	0.701000													22	94					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37328890	37328890	+	Missense_Mutation	SNP	G	G	A	rs146404001	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37328890G>A	ENST00000262825.5	+	9	1331	c.1114G>A	c.(1114-1116)Gaa>Aaa	p.E372K	CSF2RB_ENST00000406230.1_Missense_Mutation_p.E372K|CSF2RB_ENST00000403662.3_Missense_Mutation_p.E366K|CSF2RB_ENST00000536485.1_Missense_Mutation_p.E313K	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	366	Fibronectin type-III 2.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	AATGCGATACGAACACATAGA	0.567000													9	32					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84050127	84050127	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84050127G>A	ENST00000299709.3	-	8	1158	c.1159C>T	c.(1159-1161)Cca>Tca	p.P387S		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	387					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						GCCTCACCTGGGAAGATGAAG	0.567000													15	41					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432595	104432595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104432595G>A	ENST00000361820.3	-	3	2699	c.2099C>T	c.(2098-2100)cCa>cTa	p.P700L		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	700					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CAAACCAAATGGACTCTTCCA	0.493000													11	135					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890739	55890739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55890739G>A	ENST00000313472.3	+	1	891	c.891G>A	c.(889-891)gtG>gtA	p.V297V		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					ACAGAGAAGTGAAAAATGCTC	0.363000													63	126					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141135801	141135801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141135801G>A	ENST00000389484.3	-	68	11557	c.10586C>T	c.(10585-10587)tCt>tTt	p.S3529F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3529	LDL-receptor class A 26.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAACCTTGAAGAAACACAGTC	0.408000										TSP Lung(27;0.18)			17	40					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72938120	72938120	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72938120C>T	ENST00000328801.4	+	3	615	c.615C>T	c.(613-615)ttC>ttT	p.F205F		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	205						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					AGATGGTCTTCATCGGCGTCC	0.557000													12	34					0	0	1	0	0
KLRK1	22914	broad.mit.edu	37	12	10531183	10531183	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10531183G>A	ENST00000240618.6	-	6	539	c.399C>T	c.(397-399)agC>agT	p.S133S	KLRC4-KLRK1_ENST00000539300.1_3'UTR|KLRK1_ENST00000540818.1_Silent_p.S133S|RP11-277P12.20_ENST00000500682.1_RNA	NM_001199805.1|NM_007360.3	NP_001186734.1|NP_031386.2	P26718	NKG2D_HUMAN	killer cell lectin-like receptor subfamily K, member 1	133	C-type lectin.				natural killer cell activation|T cell costimulation	integral to plasma membrane	sugar binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)	9						CTTTCAGAAGGCTGGCATTTT	0.353000													39	61					0	0	1	0	0
SERPINB11	89778	broad.mit.edu	37	18	61387373	61387373	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61387373C>T	ENST00000544088.1	+	0	664				SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000538847.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				GTTAAAAGTCCTTTTCAGCTA	0.328000													4	49					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713684	46713684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46713684G>A	ENST00000318962.4	-	23	2563	c.2480C>T	c.(2479-2481)tCc>tTc	p.S827F	ALS2CL_ENST00000415953.1_Missense_Mutation_p.S827F|ALS2CL_ENST00000383742.3_Missense_Mutation_p.S174F	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	827	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CCTGACCAGGGAGTACCTCTG	0.647000													16	26					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119025518	119025518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119025518C>T	ENST00000307417.3	+	6	943	c.579C>T	c.(577-579)tgC>tgT	p.C193C	ABCG4_ENST00000531739.1_Silent_p.C193C|ABCG4_ENST00000449422.2_Silent_p.C193C	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	193	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGATGTCGTGCTCCCACACGA	0.642000													45	140					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28843514	28843514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28843514C>T	ENST00000564304.1	+	11	1493	c.1328C>T	c.(1327-1329)cCt>cTt	p.P443L	ATXN2L_ENST00000395547.2_Intron|RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000382686.4_Intron|ATXN2L_ENST00000340394.8_Intron|ATXN2L_ENST00000570200.1_Intron|ATXN2L_ENST00000336783.4_Intron|ATXN2L_ENST00000325215.6_Intron			Q8WWM7	ATX2L_HUMAN	ataxin 2-like	440						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						ACAGCTCCCCCTTTTCTTCCA	0.547000													9	47					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587388	36587388	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36587388C>T	ENST00000332987.1	-	7	1201	c.779G>A	c.(778-780)tGg>tAg	p.W260*	APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000352371.1_Nonsense_Mutation_p.W263*			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	264					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						TACATATCGCCAAGCAATCAA	0.478000													19	43					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33030907	33030907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:33030907C>T	ENST00000340811.4	-	3	1015	c.907G>A	c.(907-909)Gaa>Aaa	p.E303K	PKP2_ENST00000070846.6_Missense_Mutation_p.E303K	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	303					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GGCCCAGCTTCCCTCAGCGTG	0.667000													5	53					0	0	1	0	0
RAB17	64284	broad.mit.edu	37	2	238494746	238494746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238494746G>A	ENST00000264601.3	-	2	681	c.52C>T	c.(52-54)Cgt>Tgt	p.R18C	RAB17_ENST00000409822.1_Intron|RAB17_ENST00000538644.1_5'UTR|RAB17_ENST00000416106.1_5'UTR|RAB17_ENST00000409576.1_Intron	NM_022449.3	NP_071894.1	Q9H0T7	RAB17_HUMAN	RAB17, member RAS oncogene family	18					protein transport|small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(1)	4		Renal(207;0.00272)|Breast(86;0.00297)|all_hematologic(139;0.182)|Ovarian(221;0.221)		Epithelial(121;9.36e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.26e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000354)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.026)		TTGAACACACGGGGCTGGCTG	0.592000													33	61					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332873	70332873	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70332873G>A	ENST00000338508.4	-	32	3527	c.3528C>T	c.(3526-3528)tcC>tcT	p.S1176S	SHANK2_ENST00000423696.2_Silent_p.S796S|SHANK2_ENST00000409161.1_Silent_p.S579S|SHANK2_ENST00000449833.2_Silent_p.S580S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	796					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTTTGGACGTGGAATTCAGCG	0.697000													10	82					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15967631	15967631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:15967631G>A	ENST00000350896.3	-	9	1327	c.1130C>T	c.(1129-1131)tCa>tTa	p.S377L	MSR1_ENST00000262101.5_Missense_Mutation_p.S440L|MSR1_ENST00000445506.2_Missense_Mutation_p.S458L|MSR1_ENST00000355282.2_Missense_Mutation_p.S377L	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	440	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TTCAGAATGTGAACAGGCTCT	0.378000													42	87					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101720309	101720309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:101720309G>A	ENST00000251127.6	-	39	4488	c.4407C>T	c.(4405-4407)caC>caT	p.H1469H		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1469						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTATTTGAAAGTGGCGAAGAT	0.363000													17	53					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64669638	64669638	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64669638G>A	ENST00000421419.2	-	29	4035	c.3921C>T	c.(3919-3921)ctC>ctT	p.L1307L	ATG2A_ENST00000377264.3_Silent_p.L1305L			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1305							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						ACGCCTGAGGGAGGTGGCCAC	0.647000													22	47					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33003898	33003898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:33003898G>A	ENST00000340811.4	-	5	1288	c.1180C>T	c.(1180-1182)Ctt>Ttt	p.L394F	PKP2_ENST00000070846.6_Missense_Mutation_p.L394F	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	394					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					ATGCCACGAAGCTGGTTAACC	0.408000													24	54					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43596087	43596087	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:43596087G>A	ENST00000355710.3	+	2	486	c.254G>A	c.(253-255)tGg>tAg	p.W85*	RET_ENST00000340058.5_Nonsense_Mutation_p.W85*	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	85					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	GAGAACAACTGGATCTGCATC	0.637000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				6	29					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68696733	68696733	+	Silent	SNP	C	C	T	rs145314949	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68696733C>T	ENST00000255078.3	+	8	1254	c.1143C>T	c.(1141-1143)ctC>ctT	p.L381L		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	381	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCCAGGCCCTCGAGGCGAGCT	0.627000													24	85					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61115696	61115696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61115696C>T	ENST00000277705.6	-	2	171	c.70G>A	c.(70-72)Gaa>Aaa	p.E24K	FAM13C_ENST00000422313.2_Missense_Mutation_p.E24K|FAM13C_ENST00000435852.2_Missense_Mutation_p.E24K|FAM13C_ENST00000373867.3_5'UTR|FAM13C_ENST00000468840.2_5'UTR|FAM13C_ENST00000442566.3_Missense_Mutation_p.E24K|FAM13C_ENST00000419214.2_Missense_Mutation_p.E24K|FAM13C_ENST00000373868.2_Missense_Mutation_p.E24K			Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	24										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						ACTGGATCTTCGTCACACCTG	0.418000													26	61					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3889591	3889591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3889591C>T	ENST00000520002.1	-	4	1001	c.446G>A	c.(445-447)gGa>gAa	p.G149E	CSMD1_ENST00000542608.1_Missense_Mutation_p.G149E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G149E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G149E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G149E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G149E|CSMD1_ENST00000539096.1_Missense_Mutation_p.G149E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	149	Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGGATTTCTCCAGGATTTCC	0.418000													13	45					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561305	44561305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44561305C>T	ENST00000332567.4	-	1	683	c.331G>A	c.(331-333)Ggc>Agc	p.G111S	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	111					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TCTGGGAAGCCCCAGGCCTTT	0.662000													34	94					0	0	1	0	0
SOX17	64321	broad.mit.edu	37	8	55370910	55370910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55370910C>T	ENST00000297316.4	+	1	416	c.212C>T	c.(211-213)cCg>cTg	p.P71L		NM_022454.3	NP_071899.1	Q9H6I2	SOX17_HUMAN	SRY (sex determining region Y)-box 17	71					angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.P71Q(1)		endometrium(6)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)	18		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			ATCCGGCGGCCGATGAACGCT	0.677000													16	27					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30510708	30510708	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30510708G>A	ENST00000356798.6	+	17	2223	c.2043G>A	c.(2041-2043)cgG>cgA	p.R681R	ITGAL_ENST00000358164.5_Silent_p.R598R|ITGAL_ENST00000433423.2_Silent_p.R77R|RP11-297C4.1_ENST00000563751.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	681					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	ATGGCCACCGGACCAGAAGAC	0.547000													13	163					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307420	140307420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140307420G>A	ENST00000253807.2	+	1	943	c.943G>A	c.(943-945)Gaa>Aaa	p.E315K	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.E315K|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGGGACGAAGGTGTCTT	0.547000													54	133					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807786	20807786	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20807786G>T	ENST00000601440.1	-	4	1043	c.897C>A	c.(895-897)acC>acA	p.T299T	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						GTGTAGTAAGGGTTGAGGACC	0.368000													16	140					6.31663e-08	6.33595e-08	1	1	0
CALN1	83698	broad.mit.edu	37	7	71743780	71743780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:71743780G>A	ENST00000395275.2	-	3	523	c.135C>T	c.(133-135)ttC>ttT	p.F45F	CALN1_ENST00000329008.5_Silent_p.F3F|CALN1_ENST00000405452.2_Silent_p.F3F|CALN1_ENST00000395276.2_Silent_p.F3F|CALN1_ENST00000431984.1_Silent_p.F3F|CALN1_ENST00000412588.1_Silent_p.F45F	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	3	EF-hand 1.					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TCACATGGTGGAACGGCATCT	0.498000													12	47					0	0	1	0	0
PROSER2	254427	broad.mit.edu	37	10	11911718	11911718	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11911718G>A	ENST00000277570.5	+	4	775	c.621G>A	c.(619-621)ggG>ggA	p.G207G	PROSER2-AS1_ENST00000453242.1_RNA|PROSER2_ENST00000379200.1_Silent_p.G11G|PROSER2-AS1_ENST00000445498.1_RNA	NM_153256.3	NP_694988.3			proline and serine-rich protein 2																		GGATGGCGGGGAACGAAGCCC	0.731000													7	6					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57176870	57176870	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:57176870C>T	ENST00000504228.1	+	4	429	c.324C>T	c.(322-324)ctC>ctT	p.L108L	KIAA1211_ENST00000264229.6_Silent_p.L108L|KIAA1211_ENST00000541073.1_Silent_p.L101L|KIAA1211_ENST00000505410.1_3'UTR			Q6ZU35	K1211_HUMAN	KIAA1211	108										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CTCTGAATCTCCCTGGAGCTG	0.423000													27	64					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150416156	150416156	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150416156G>A	ENST00000307194.5	+	2	161	c.21G>A	c.(19-21)gcG>gcA	p.A7A		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAAGATGGCGACAGATGAAG	0.413000													43	94					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56552397	56552397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56552397G>A	ENST00000390649.3	+	11	2896	c.2896G>A	c.(2896-2898)Gaa>Aaa	p.E966K		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	966						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCTGGGGAACGAAGGTGTAAA	0.567000													51	142					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55279591	55279591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55279591G>A	ENST00000358193.3	+	7	921	c.867G>A	c.(865-867)ccG>ccA	p.P289P	C1orf177_ENST00000371273.3_Silent_p.P289P	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	289										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CCCGAAACCCGAAAACCCCTA	0.502000													38	122					0	0	1	0	0
VSTM2L	128434	broad.mit.edu	37	20	36572431	36572431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36572431C>T	ENST00000373461.4	+	4	638	c.391C>T	c.(391-393)Cgg>Tgg	p.R131W	VSTM2L_ENST00000373459.4_Missense_Mutation_p.P57L|VSTM2L_ENST00000373458.3_Missense_Mutation_p.R114W	NM_080607.2	NP_542174.1	Q96N03	VTM2L_HUMAN	V-set and transmembrane domain containing 2 like	131	Ig-like.									central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(1)|skin(1)	8		Myeloproliferative disorder(115;0.00878)				GCGCCTGTCCCGGGTGAAGCC	0.642000													3	25					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60377841	60377841	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60377841C>T	ENST00000371204.3	-	3	559	c.516G>A	c.(514-516)gaG>gaA	p.E172E	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	172					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					CACCGTTCTCCTCTTTTATTG	0.458000													18	31					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502563	140502563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140502563G>A	ENST00000194152.1	+	1	983	c.983G>A	c.(982-984)gGa>gAa	p.G328E		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		328	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCCTTTCTGGAAAAGGCACT	0.418000													95	211					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81699006	81699006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:81699006G>A	ENST00000429644.2	-	4	1139	c.496C>T	c.(496-498)Cgt>Tgt	p.R166C	GBE1_ENST00000489715.1_Missense_Mutation_p.R125C	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	166					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TCACCTTCACGAACCACATAC	0.333000									Glycogen Storage Disease, type IV				14	45					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17488061	17488061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17488061G>A	ENST00000252590.4	-	1	98	c.37C>T	c.(37-39)Cgg>Tgg	p.R13W		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	13						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCCCCCGCCCGAGCGTAGGAC	0.652000													12	126					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887521	9887521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:9887521G>A	ENST00000306084.6	+	2	1244	c.1045G>A	c.(1045-1047)Gaa>Aaa	p.E349K	TXNDC2_ENST00000357775.4_Missense_Mutation_p.E282K|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	349	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						CAAGTCCCCAGAAGAAACCAT	0.562000													68	137					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70998852	70998852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70998852G>A	ENST00000354624.5	+	5	683	c.550G>A	c.(550-552)Gat>Aat	p.D184N	HKDC1_ENST00000395086.2_Missense_Mutation_p.D184N	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	184					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TCAGGACACGGATGTGGTGAG	0.512000													11	40					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78638703	78638703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78638703G>A	ENST00000545128.1	+	4	999	c.461G>A	c.(460-462)gGa>gAa	p.G154E	PCSK5_ENST00000376752.4_Missense_Mutation_p.G154E|PCSK5_ENST00000376767.3_Missense_Mutation_p.G154E	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	154	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						AATATCGAAGGAGCCTGGAAG	0.453000													16	88					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072763	17072763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17072763C>T	ENST00000359963.3	-	1	937	c.678G>A	c.(676-678)ggG>ggA	p.G226G		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	226					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CACAGAGCTTCCCAGATATTG	0.607000													12	97					0	0	1	0	0
TCL1B	9623	broad.mit.edu	37	14	96157628	96157628	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96157628C>T	ENST00000340722.7	+	3	408	c.357C>T	c.(355-357)gtC>gtT	p.V119V	RP11-1070N10.6_ENST00000461160.1_RNA	NM_004918.3	NP_004909.1	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	119										cervix(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		AGCAGCTGGTCCTAACATATC	0.562000													8	23					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430806	37430806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37430806G>A	ENST00000374660.1	+	7	912	c.813G>A	c.(811-813)gaG>gaA	p.E271E	ANKRD30A_ENST00000361713.1_Silent_p.E271E|ANKRD30A_ENST00000602533.1_Silent_p.E271E			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	327						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CACCTGATGAGGCTGCATCCT	0.473000													17	55					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4069536	4069536	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:4069536T>G	ENST00000274673.3	-	7	1324	c.921A>C	c.(919-921)agA>agC	p.R307S	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	307																	TCGTTTGTAGTCTTGGCCTCT	0.433000													40	85					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069466	6069466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:6069466G>A	ENST00000381095.3	-	2	669	c.42C>T	c.(40-42)ttC>ttT	p.F14F	NLGN4X_ENST00000469740.1_5'UTR|NLGN4X_ENST00000275857.6_Silent_p.F14F|NLGN4X_ENST00000538097.1_Silent_p.F14F|NLGN4X_ENST00000381093.2_Silent_p.F14F|NLGN4X_ENST00000381092.1_Silent_p.F14F	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	14					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity	p.F14L(1)		breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						AGACCGGGGTGAACAACAAAG	0.512000													22	21					0	0	1	0	0
NKG7	4818	broad.mit.edu	37	19	51875645	51875645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51875645C>T	ENST00000221978.5	-	1	324	c.145G>A	c.(145-147)Gac>Aac	p.D49N	NKG7_ENST00000600427.1_Missense_Mutation_p.D49N|NKG7_ENST00000595217.1_Missense_Mutation_p.D49N	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	49						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GATATGATGTCCCCATGCCCT	0.582000													52	164					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32366635	32366635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:32366635G>A	ENST00000357033.4	-	38	5542	c.5336C>T	c.(5335-5337)cCt>cTt	p.P1779L	DMD_ENST00000378677.2_Missense_Mutation_p.P1775L	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1779	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTCCTTCAAAGGAATGGAGGC	0.343000													14	9					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73477502	73477502	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73477502C>T	ENST00000252034.7	+	27	2205	c.1806C>T	c.(1804-1806)gtC>gtT	p.V602V	ELN_ENST00000380576.5_Silent_p.V583V|ELN_ENST00000458204.1_Silent_p.V592V|ELN_ENST00000380575.4_Silent_p.V573V|ELN_ENST00000320492.7_Silent_p.V521V|ELN_ENST00000414324.1_Silent_p.V578V|ELN_ENST00000380553.4_Silent_p.V466V|ELN_ENST00000357036.5_Silent_p.V607V|ELN_ENST00000429192.1_Silent_p.V588V|ELN_ENST00000380584.4_Silent_p.V554V|ELN_ENST00000358929.4_Silent_p.V670V|ELN_ENST00000445912.1_Silent_p.V602V|ELN_ENST00000380562.4_Silent_p.V608V|ELN_ENST00000320399.6_Silent_p.V635V	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	664	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGCCTGGGGTCCTTGGAGGGC	0.622000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						8	17					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36349316	36349316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36349316C>T	ENST00000360202.5	+	3	416	c.218C>T	c.(217-219)tCc>tTc	p.S73F	NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000586102.2_Missense_Mutation_p.S73F|KIRREL2_ENST00000347900.6_Missense_Mutation_p.S23F|KIRREL2_ENST00000262625.7_Missense_Mutation_p.S73F|KIRREL2_ENST00000592409.1_Missense_Mutation_p.S73F	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	73	Ig-like C2-type 1.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCAGGGTGGTCCCGGTACTGG	0.557000													25	56					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69736497	69736497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69736497G>A	ENST00000409085.4	-	14	2248	c.1872C>T	c.(1870-1872)tcC>tcT	p.S624S	AAK1_ENST00000406297.3_Silent_p.S624S|AAK1_ENST00000409068.1_Silent_p.S624S	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	624						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						GGGTTTTGGGGGATGAGGGTG	0.567000													6	61					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358893	72358893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72358893C>T	ENST00000441259.1	-	3	744	c.584G>A	c.(583-585)aGg>aAg	p.R195K	PRF1_ENST00000373209.2_Missense_Mutation_p.R195K	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	195	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						CCCGAGGGCCCTCTTGAAGTC	0.612000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				7	41					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197765482	197765482	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:197765482C>T	ENST00000330198.4	+	16	1934	c.1912C>T	c.(1912-1914)Ctg>Ttg	p.L638L	LMLN_ENST00000482695.1_Silent_p.L623L|LMLN-AS1_ENST00000423460.1_RNA|LMLN_ENST00000332636.5_Silent_p.L586L|LMLN_ENST00000420910.2_Silent_p.L675L	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	638					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CCTCTGGCTTCTGCTAGGCAA	0.393000													25	91					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838960	112838960	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:112838960G>A	ENST00000280155.2	+	1	2171	c.1206G>A	c.(1204-1206)tgG>tgA	p.W402*		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	387					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	TGGTGTGCTGGTTCCCCTTCT	0.632000													27	75					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65489842	65489842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65489842G>A	ENST00000261883.4	-	9	2948	c.2782C>T	c.(2782-2784)Ccc>Tcc	p.P928S		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	928					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix		p.P928T(1)		breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TCGTTGAAGGGGACTGTGTTG	0.522000													25	154					0	0	1	0	0
FGF20	26281	broad.mit.edu	37	8	16850716	16850716	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16850716C>T	ENST00000180166.5	-	3	649	c.501G>A	c.(499-501)gtG>gtA	p.V167V		NM_019851.2	NP_062825.1	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	167					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	11				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TGTTAAGTGCCACAAAATACC	0.433000													22	177					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56485099	56485099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56485099G>A	ENST00000291971.3	+	7	2687	c.2616G>A	c.(2614-2616)ctG>ctA	p.L872L	NLRP8_ENST00000590542.1_Silent_p.L853L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	872						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TGACCCACCTGAGCTTGGCAG	0.517000													70	175					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100680818	100680818	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100680818G>A	ENST00000306151.4	+	3	6185	c.6121G>A	c.(6121-6123)Gaa>Aaa	p.E2041K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2041	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.E2041K(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAACGGACCAC	0.498000													76	223					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6712527	6712527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6712527C>T	ENST00000245907.6	-	10	1203	c.1111G>A	c.(1111-1113)Gac>Aac	p.D371N		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	371					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACCATGAGGTCAAAGGGCATT	0.632000													30	144					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159680709	159680709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:159680709G>A	ENST00000393977.3	-	7	1269	c.984C>T	c.(982-984)ttC>ttT	p.F328F	CCNJL_ENST00000257536.7_Silent_p.F280F|CCNJL_ENST00000377503.2_5'UTR	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	328						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGGTGGCTGGAACAGCACTT	0.642000													16	44					0	0	1	0	0
CNR2	1269	broad.mit.edu	37	1	24201316	24201316	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24201316G>A	ENST00000536471.1	-	3	1050	c.792C>T	c.(790-792)ctC>ctT	p.L264L	CNR2_ENST00000374472.4_Silent_p.L264L			P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	264					behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	TGTGGGCCATGAGGGCCAGCA	0.577000													8	68					0	0	1	0	0
EXOC7	23265	broad.mit.edu	37	17	74087233	74087233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74087233G>A	ENST00000607838.1	-	7	986	c.892C>T	c.(892-894)Cct>Tct	p.P298S	EXOC7_ENST00000411744.2_Intron|EXOC7_ENST00000467929.2_Missense_Mutation_p.P257S|EXOC7_ENST00000405575.4_Missense_Mutation_p.P298S|EXOC7_ENST00000335146.7_Missense_Mutation_p.P298S|EXOC7_ENST00000332065.5_Intron|EXOC7_ENST00000589210.1_Missense_Mutation_p.P298S	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	298					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			CCTTCCAGAGGAATGAGGTTA	0.577000													50	178					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147743900	147743900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:147743900G>A	ENST00000370460.2	+	3	1131	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K	AFF2_ENST00000370458.1_Missense_Mutation_p.E214K|AFF2_ENST00000370457.5_Missense_Mutation_p.E214K|AFF2_ENST00000342251.3_Missense_Mutation_p.E214K	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	218					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding	p.E218K(1)		breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					ATCTGCAAAGGAAGACAGTAA	0.468000													97	53					0	0	1	0	0
CELF4	56853	broad.mit.edu	37	18	34839097	34839097	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:34839097T>C	ENST00000588597.1	-	11	1353	c.1344A>G	c.(1342-1344)caA>caG	p.Q448Q	CELF4_ENST00000361795.5_Intron|CELF4_ENST00000601019.1_Intron|CELF4_ENST00000412753.1_Intron|CELF4_ENST00000591282.1_Intron|CELF4_ENST00000334919.5_Intron|CELF4_ENST00000591287.1_Intron|CELF4_ENST00000603232.1_Intron|CELF4_ENST00000420428.2_Intron			Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	93	RRM 3.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						AGCATTTACTTTGGTTAGTCG	0.507000													12	20					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120740003	120740003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120740003C>T	ENST00000310396.5	+	7	1240	c.773C>T	c.(772-774)cCa>cTa	p.P258L	CPED1_ENST00000423795.1_Missense_Mutation_p.P38L|CPED1_ENST00000450913.2_Missense_Mutation_p.P258L	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		GTCCTTGCTCCACATGAAACA	0.383000													18	76					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156761529	156761529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156761529C>T	ENST00000271526.4	+	4	1396	c.1124C>T	c.(1123-1125)gCc>gTc	p.A375V	PRCC_ENST00000353233.3_Intron|PRCC_ENST00000491853.1_3'UTR	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	375					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGGACCCGGCCCTGGTCCCC	0.537000			T	TFE3	papillary renal								19	84					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18156698	18156698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18156698G>A	ENST00000327031.4	-	9	1155	c.930C>T	c.(928-930)ccC>ccT	p.P310P	FLII_ENST00000578558.1_Silent_p.P310P|FLII_ENST00000545457.2_Silent_p.P256P|FLII_ENST00000379450.4_Silent_p.P225P|FLII_ENST00000579294.1_Silent_p.P299P|FLII_ENST00000584444.1_5'UTR	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	310	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					CAATGCCTGAGGGCAGCCCGT	0.582000													7	48					0	0	1	0	0
MMP7	4316	broad.mit.edu	37	11	102398304	102398304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102398304C>T	ENST00000260227.4	-	3	487	c.435G>A	c.(433-435)agG>agA	p.R145R		NM_002423.3	NP_002414.1	P09237	MMP7_HUMAN	matrix metallopeptidase 7 (matrilysin, uterine)	145					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		ATACAACTTTCCTGAAATGCA	0.443000													43	98					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94137937	94137937	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94137937A>G	ENST00000282020.4	+	6	1096	c.838A>G	c.(838-840)Agg>Ggg	p.R280G	GRID2_ENST00000510992.1_Missense_Mutation_p.R185G|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	280					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GTCAATTGGAAGGTTAACGAT	0.393000													41	169					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125094666	125094666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125094666G>A	ENST00000522917.1	+	33	4564	c.4358G>A	c.(4357-4359)cGa>cAa	p.R1453Q	FER1L6_ENST00000399018.1_Missense_Mutation_p.R1453Q|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1453						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AGCAAACACCGAGCCATCTGT	0.498000													70	122					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123036904	123036904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123036904G>A	ENST00000462833.1	-	11	3529	c.2317C>T	c.(2317-2319)Ctc>Ttc	p.L773F	ADCY5_ENST00000309879.5_Missense_Mutation_p.L423F|ADCY5_ENST00000491190.1_Missense_Mutation_p.L406F	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	773					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CAGATGAAGAGGAAGACGAGC	0.597000													7	83					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51380289	51380289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51380289C>T	ENST00000358049.4	+	4	671	c.655C>T	c.(655-657)Ctg>Ttg	p.L219L	KLK2_ENST00000391810.2_Intron|KLK2_ENST00000325321.3_Intron	NM_001002231.2|NM_005551.4	NP_001002231.1|NP_005542.1	P20151	KLK2_HUMAN	kallikrein-related peptidase 2	0	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		CTCCCAACATCTGGAGGGGAA	0.537000			T	ETV4	prostate								28	95					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75107041	75107041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75107041C>T	ENST00000326665.5	-	5	636	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	140										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GAATGTCCTTCATCAACCAGA	0.423000													22	104					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123932070	123932070	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123932070G>A	ENST00000373855.1	+	39	6512	c.6252G>A	c.(6250-6252)cgG>cgA	p.R2084R	CNTRL_ENST00000373850.1_Silent_p.R1532R|CNTRL_ENST00000238341.5_Silent_p.R2084R|CNTRL_ENST00000373845.2_3'UTR			Q7Z7A1	CNTRL_HUMAN	centriolin	2084	Required for centrosome localization.|Sufficient for interaction with HOOK2.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						AGATCCAGCGGAGCCAGCTGG	0.468000													28	69					0	0	1	0	0
C15orf48	84419	broad.mit.edu	37	15	45724270	45724270	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45724270C>T	ENST00000344300.3	+	3	313	c.122_splice	c.e3-1	p.I41_splice	C15orf48_ENST00000396650.2_Splice_Site_p.I41_splice|RP11-519G16.5_ENST00000559553.1_RNA	NM_032413.3	NP_115789.1	Q9C002	NMES1_HUMAN	chromosome 15 open reading frame 48	41						nucleus				large_intestine(1)|lung(2)|ovary(1)	4		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.67e-16)|GBM - Glioblastoma multiforme(94;1.71e-06)		TTAATTTTAGCCTTGATCGAA	0.318000													8	36					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48565299	48565299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48565299G>A	ENST00000354276.3	-	14	1540	c.1213C>T	c.(1213-1215)Cac>Tac	p.H405Y	PLA2G4C_ENST00000413144.2_Missense_Mutation_p.H405Y|CTD-2265M8.2_ENST00000596552.1_RNA|PLA2G4C_ENST00000596510.1_5'UTR|CTD-2265M8.2_ENST00000601548.1_RNA|CTD-2265M8.2_ENST00000601950.1_RNA|PLA2G4C_ENST00000599921.1_Missense_Mutation_p.H405Y|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.H415Y	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	405	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		AGGATGAGGTGAACCTCCCGC	0.612000													34	103					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87027688	87027688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:87027688G>A	ENST00000398399.2	-	2	754	c.391C>T	c.(391-393)Ccc>Tcc	p.P131S	VGLL3_ENST00000383698.3_Missense_Mutation_p.P131S	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CGCCATAGGGGGGTTAGCCCC	0.507000													41	93					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183673094	183673094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183673094C>T	ENST00000511685.1	+	20	3894	c.3771C>T	c.(3769-3771)gtC>gtT	p.V1257V	TENM3_ENST00000406950.2_Silent_p.V1257V|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		CAGAAGTCGTCGCAGGGACAG	0.537000													17	48					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111887485	111887485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111887485G>A	ENST00000440460.2	+	19	2121	c.1824G>A	c.(1822-1824)cgG>cgA	p.R608R	DIXDC1_ENST00000389821.4_3'UTR|DIXDC1_ENST00000315253.5_Silent_p.R397R	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	609	DIX.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		TCACTGACCGGTCACTTACGC	0.438000													6	8					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095473	167095473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167095473G>A	ENST00000361200.2	+	6	1271	c.1105G>A	c.(1105-1107)Gga>Aga	p.G369R	DUSP27_ENST00000443333.1_Missense_Mutation_p.G369R|DUSP27_ENST00000485151.1_3'UTR|DUSP27_ENST00000271385.5_Missense_Mutation_p.G369R			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	369					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCCCCAGGATGGAGGTGGCTG	0.632000													3	6					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770916	53770916	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53770916C>T	ENST00000311170.4	-	1	56	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	1					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		ACCGGGAGGCCATTCTGCCAC	0.507000										HNSCC(26;0.072)			20	54					0	0	1	0	0
WDR37	22884	broad.mit.edu	37	10	1149546	1149546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:1149546C>T	ENST00000358220.1	+	10	875	c.731C>T	c.(730-732)tCt>tTt	p.S244F	WDR37_ENST00000263150.4_Missense_Mutation_p.S244F			Q9Y2I8	WDR37_HUMAN	WD repeat domain 37	244										breast(2)|endometrium(2)|kidney(1)|lung(9)|prostate(2)|skin(1)	17		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		CAGCAGATATCTGGGGAAGAT	0.498000													13	38					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130187862	130187862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130187862C>T	ENST00000265379.6	+	38	7508	c.7014C>T	c.(7012-7014)gtC>gtT	p.V2338V	COL6A5_ENST00000432398.2_Silent_p.V2338V			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2338	Nonhelical region.|VWFA 10.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						GGGTTGCTGTCCTGAGCTACT	0.428000													10	30					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11971966	11971966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:11971966C>T	ENST00000339865.5	+	23	4079	c.3316C>T	c.(3316-3318)Cat>Tat	p.H1106Y	USP47_ENST00000539466.1_5'UTR|USP47_ENST00000399455.2_Missense_Mutation_p.H1194Y|USP47_ENST00000527733.1_Missense_Mutation_p.H1174Y	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	1194					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		TTTGGATTATCATATTTATGA	0.323000													39	106					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20648554	20648554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20648554G>A	ENST00000219151.4	-	9	1268	c.58C>T	c.(58-60)Cat>Tat	p.H20Y	ACSM1_ENST00000520010.1_Intron|ACSM1_ENST00000307493.4_Intron			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	399					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						GCCTCCATATGAAACTGAAGG	0.507000													22	78					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176809404	176809404	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176809404G>A	ENST00000367662.3	+	22	6462	c.5298G>A	c.(5296-5298)aaG>aaA	p.K1766K		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1766					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TCTCCTCCAAGAAGGTGAGTG	0.522000													25	91					0	0	1	0	0
PRMT3	10196	broad.mit.edu	37	11	20483679	20483679	+	Missense_Mutation	SNP	C	C	T	rs142036289		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20483679C>T	ENST00000331079.6	+	12	1443	c.1226C>T	c.(1225-1227)cCg>cTg	p.P409L	PRMT3_ENST00000437750.2_Missense_Mutation_p.P347L	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779.1	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	409							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						GTTTTAGATCCGAAGACTCTT	0.348000													69	174					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10132199	10132199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:10132199C>T	ENST00000324907.9	+	11	1522	c.1386C>T	c.(1384-1386)ccC>ccT	p.P462P	GRHL1_ENST00000324883.5_Silent_p.P273P|GRHL1_ENST00000405379.2_Silent_p.P462P	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	462					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TTTTCAAACCCTTCATTGATC	0.448000													30	28					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13692204	13692204	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13692204C>T	ENST00000265104.4	-	79	13868	c.13764G>A	c.(13762-13764)aaG>aaA	p.K4588K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4588					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GAACTGGCTTCTTATAGATGG	0.478000									Kartagener syndrome				29	73					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55566682	55566682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55566682G>A	ENST00000373965.2	-	36	5106	c.4712C>T	c.(4711-4713)tCc>tTc	p.S1571F	PCDH15_ENST00000414778.1_Missense_Mutation_p.S1568F	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	422					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCGAACAGGGGAAGCAACTTT	0.458000										HNSCC(58;0.16)			39	175					0	0	1	0	0
AMOTL2	51421	broad.mit.edu	37	3	134085246	134085246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134085246G>A	ENST00000514516.1	-	4	1417	c.1239C>T	c.(1237-1239)ctC>ctT	p.L413L	AMOTL2_ENST00000422605.2_Silent_p.L355L|AMOTL2_ENST00000513145.1_Silent_p.L355L|AMOTL2_ENST00000249883.5_Silent_p.L355L	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	355										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						GGGCCTCAGAGAGCCGCTGGA	0.577000													8	102					0	0	1	0	0
DEGS2	123099	broad.mit.edu	37	14	100615658	100615658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100615658G>A	ENST00000305631.5	-	2	1047	c.472C>T	c.(472-474)Cgc>Tgc	p.R158C	DEGS2_ENST00000553834.1_Intron|DEGS2_ENST00000557117.1_5'UTR	NM_206918.2	NP_996801.2	Q6QHC5	DEGS2_HUMAN	delta(4)-desaturase, sphingolipid 2	158					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity			breast(1)|lung(6)|skin(1)	8		Melanoma(154;0.212)				AGCAGCTTGCGGGCGGGTGTG	0.662000													17	35					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30018572	30018572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30018572C>T	ENST00000350119.4	-	6	766	c.576G>A	c.(574-576)ggG>ggA	p.G192G	DOC2A_ENST00000564944.1_Silent_p.G192G|DOC2A_ENST00000564979.1_Silent_p.G192G	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	192	C2 1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						CGCGGATCTCCCCAATAAACT	0.622000													32	62					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58583660	58583660	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58583660T>G	ENST00000317147.5	-	25	3817	c.3485A>C	c.(3484-3486)aAc>aCc	p.N1162T	CNOT1_ENST00000569240.1_Missense_Mutation_p.N1157T|CNOT1_ENST00000441024.2_Missense_Mutation_p.N1162T|CNOT1_ENST00000245138.4_Missense_Mutation_p.N52T	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1162					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AACCATCTTGTTAAATTCAGG	0.328000													39	108					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17038904	17038904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17038904C>T	ENST00000443236.1	-	25	3457	c.3426G>A	c.(3424-3426)gtG>gtA	p.V1142V		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1095						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						AGCTCTCGTCCACCTCCATCT	0.642000													24	62					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25670448	25670448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25670448C>T	ENST00000281589.3	+	1	149	c.112C>T	c.(112-114)Ctc>Ttc	p.L38F		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	38	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AGGGCCCATCCTCTCCATCCG	0.622000													29	75					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6386953	6386953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6386953G>A	ENST00000262483.8	-	6	558	c.471C>T	c.(469-471)ttC>ttT	p.F157F	ACKR6_ENST00000421306.3_Silent_p.F121F	NM_031220.3	NP_112497.2																					GCACGGAGCTGAAGGTGTGGA	0.617000													16	30					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072451	17072451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17072451C>T	ENST00000359963.3	-	1	1249	c.990G>A	c.(988-990)ttG>ttA	p.L330L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	330					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GAGGTGTGTCCAACACCTCAC	0.567000													48	146					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141108493	141108493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141108493C>T	ENST00000389484.3	-	77	12736	c.11765G>A	c.(11764-11766)aGa>aAa	p.R3922K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3922					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.R3922I(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCTGTTATTCTTGAATTATG	0.343000										TSP Lung(27;0.18)			15	146					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56128269	56128269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56128269C>T	ENST00000303039.3	+	1	579	c.547C>T	c.(547-549)Cct>Tct	p.P183S		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					TGATAATGTTCCTCTGTTAGC	0.338000													24	54					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56511255	56511255	+	Silent	SNP	G	G	A	rs61735257	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56511255G>A	ENST00000302957.3	-	1	32	c.33C>T	c.(31-33)ttC>ttT	p.F11F		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CCACGGAGGTGAAAGCCTGAC	0.413000													35	98					0	0	1	0	0
MAP4K3	8491	broad.mit.edu	37	2	39515267	39515267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:39515267G>A	ENST00000263881.3	-	20	1793	c.1469C>T	c.(1468-1470)gCc>gTc	p.A490V	MAP4K3_ENST00000341681.5_Missense_Mutation_p.A469V|MAP4K3_ENST00000437545.1_Missense_Mutation_p.A406V|MAP4K3_ENST00000536018.1_Missense_Mutation_p.A43V	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	490					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				ATTACCTAAGGCAACAGGTTT	0.438000													58	138					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23775187	23775187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23775187G>A	ENST00000354639.3	+	7	909	c.445G>A	c.(445-447)Gaa>Aaa	p.E149K	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Missense_Mutation_p.E172K|STK31_ENST00000355870.3_Missense_Mutation_p.E172K|STK31_ENST00000428484.1_Missense_Mutation_p.E149K	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	172							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CTTGATTTTTGAAAAGGAAAT	0.388000													40	102					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282509	69282509	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69282509C>T	ENST00000338352.2	+	1	169	c.135C>T	c.(133-135)ctC>ctT	p.L45L		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	45										autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						AGCAGTTGCTCCAAGACGTGG	0.582000													5	7					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130509543	130509543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130509543G>A	ENST00000314830.8	-	6	1260	c.1147C>T	c.(1147-1149)Ctg>Ttg	p.L383L	SH2D3C_ENST00000420366.1_Silent_p.L225L|SH2D3C_ENST00000373274.3_Silent_p.L223L|SH2D3C_ENST00000373276.3_Silent_p.L315L|SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Silent_p.L226L|SH2D3C_ENST00000429553.1_Silent_p.L29L	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	383					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GGGCGGGGCAGCGACGTACTG	0.657000													8	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179447116	179447116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179447116C>T	ENST00000589042.1	-	314	66291	c.66067G>A	c.(66067-66069)Ggc>Agc	p.G22023S	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G19455S|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G20382S|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G13150S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G13083S|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G12958S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20382	Ig-like 115.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTCATGGCCCTCTATAAGT	0.453000													19	44					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18250623	18250623	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:18250623G>C	ENST00000377369.2	+	3	648	c.375G>C	c.(373-375)caG>caC	p.Q125H	SLC39A12_ENST00000377371.3_Missense_Mutation_p.Q125H|SLC39A12_ENST00000377374.4_Missense_Mutation_p.Q125H|SLC39A12_ENST00000539911.1_5'UTR	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	125					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						TTATTCATCAGGAAGAGATCT	0.383000													28	70					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440305	40440305	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40440305C>T	ENST00000319592.4	-	4	1315	c.606G>A	c.(604-606)gaG>gaA	p.E202E	RBM47_ENST00000381793.2_Silent_p.E202E|RBM47_ENST00000381795.6_Silent_p.E202E|RBM47_ENST00000295971.7_Silent_p.E202E|RBM47_ENST00000514014.1_Silent_p.E164E|RBM47_ENST00000515809.1_Intron			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	202	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CGCGGTGGCTCTCGTACTCCA	0.662000													17	64					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301413	11301413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11301413C>T	ENST00000397056.1	+	3	881	c.690C>T	c.(688-690)tcC>tcT	p.S230S	HRH1_ENST00000431010.2_Silent_p.S230S|HRH1_ENST00000438284.2_Silent_p.S230S	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	230					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TCAATAGGTCCCTCCCTTCCT	0.537000													32	61					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240635690	240635690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240635690G>A	ENST00000319653.9	+	17	5309	c.5079G>A	c.(5077-5079)gaG>gaA	p.E1693E	FMN2_ENST00000545751.1_Silent_p.E289E|FMN2_ENST00000543681.1_Silent_p.E13E|FMN2_ENST00000496950.1_3'UTR|AL646016.1_ENST00000596886.1_Intron	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1693	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAGCCGAAGAGGTGTGTAGAC	0.333000													27	74					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163027502	163027502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163027502G>A	ENST00000188790.4	-	26	2477	c.2270C>T	c.(2269-2271)tCt>tTt	p.S757F	AC007750.5_ENST00000418968.2_RNA|FAP_ENST00000443424.1_Missense_Mutation_p.S732F	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	757					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						GTCTGACAAAGAGAAACACTG	0.413000													15	149					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110464387	110464387	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110464387G>A	ENST00000378402.5	+	42	6489	c.6385G>A	c.(6385-6387)Gaa>Aaa	p.E2129K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2129	IPT/TIG 14.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CACCATAGCTGAAGCCAAATG	0.398000										HNSCC(38;0.096)			20	28					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	121960374	121960374	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121960374G>A	ENST00000334010.7	-	28	4151	c.3730C>T	c.(3730-3732)Cga>Tga	p.R1244*	CADPS2_ENST00000313070.7_Nonsense_Mutation_p.R1205*|CADPS2_ENST00000449022.2_Nonsense_Mutation_p.R1246*|CADPS2_ENST00000412584.2_Nonsense_Mutation_p.R1205*	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	1246					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding	p.R1243*(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						CCCTGCAATCGAAAGTCCCTG	0.398000													57	144					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117403125	117403125	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117403125G>A	ENST00000321322.6	-	4	805	c.804C>T	c.(802-804)acC>acT	p.T268T	DSCAML1_ENST00000527706.1_Intron	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	208	Ig-like C2-type 3.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGCTCTGCCGGGTCTCCCCGC	0.612000													9	77					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61232797	61232797	+	Silent	SNP	C	C	T	rs143516663		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61232797C>T	ENST00000382768.1	+	6	825	c.825C>T	c.(823-825)ttC>ttT	p.F275F	SERPINB12_ENST00000269491.1_Silent_p.F255F			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	255					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TCAGCATGTTCGTGCTGCTGC	0.428000													12	105					0	0	1	0	0
PHGDH	26227	broad.mit.edu	37	1	120279789	120279789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120279789C>T	ENST00000369407.3	+	7	2250	c.743C>T	c.(742-744)cCc>cTc	p.P248L	PHGDH_ENST00000369409.4_Missense_Mutation_p.P282L			O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	282					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	18	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	ATCAGCTGTCCCCACCTGGGT	0.592000													16	35					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29194912	29194912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:29194912G>A	ENST00000240100.2	-	4	1205	c.816C>T	c.(814-816)tgC>tgT	p.C272C	DUSP4_ENST00000240101.2_Silent_p.C181C	NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	272	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		CGCGCCCACGGCAGTCCTTCA	0.667000													21	74					0	0	1	0	0
MISP	126353	broad.mit.edu	37	19	757886	757886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:757886C>T	ENST00000215582.6	+	2	1043	c.940C>T	c.(940-942)Cgg>Tgg	p.R314W		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GAGGGGGCTTCGGCAGGCAAC	0.687000													15	24					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238296801	238296801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238296801G>A	ENST00000295550.4	-	4	1188	c.736C>T	c.(736-738)Ctt>Ttt	p.L246F	COL6A3_ENST00000353578.4_Missense_Mutation_p.L40F|COL6A3_ENST00000392004.3_Missense_Mutation_p.L40F|COL6A3_ENST00000392003.2_Intron|COL6A3_ENST00000409809.1_Missense_Mutation_p.L40F|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000346358.4_Missense_Mutation_p.L246F|COL6A3_ENST00000347401.3_Intron	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	246	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCATCAATAAGGAAAATAATG	0.378000													21	73					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52941923	52941923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52941923C>T	ENST00000332323.6	+	4	1310	c.1249C>T	c.(1249-1251)Cat>Tat	p.H417Y	ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Missense_Mutation_p.H404Y|ZNF534_ENST00000301085.4_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						TAGGAAAATTCATACTGGGGG	0.428000													3	6					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345124	20345124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20345124C>T	ENST00000298642.2	+	1	734	c.698C>T	c.(697-699)tCa>tTa	p.S233L		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCCAGAGGATCATCTAAGGCC	0.388000													54	141					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8151201	8151201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8151201C>T	ENST00000600128.1	-	55	7177	c.6763G>A	c.(6763-6765)Gaa>Aaa	p.E2255K	FBN3_ENST00000601739.1_Missense_Mutation_p.E2255K|FBN3_ENST00000270509.2_Missense_Mutation_p.E2255K			Q75N90	FBN3_HUMAN	fibrillin 3	2255	EGF-like 37; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GCGTGGCATTCATTGTCATCT	0.652000													49	114					0	0	1	0	0
NDRG1	10397	broad.mit.edu	37	8	134261013	134261013	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134261013G>A	ENST00000414097.2	-	11	1567	c.698_splice	c.e11-1	p.R234_splice	NDRG1_ENST00000537882.1_Splice_Site_p.R153_splice|NDRG1_ENST00000521414.1_5'UTR|NDRG1_ENST00000518066.1_Intron|NDRG1_ENST00000518176.1_Intron|NDRG1_ENST00000323851.7_Splice_Site_p.R234_splice|NDRG1_ENST00000522476.1_Splice_Site_p.R168_splice|NDRG1_ENST00000354944.5_Splice_Site_p.R164_splice	NM_001135242.1	NP_001128714.1	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	234					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding		NDRG1/ERG(5)	endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(4)|prostate(1)|skin(1)	17	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			AGGTCGCGCCGGCTGCAGGAA	0.607000			T	ERG	prostate								11	100					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101606018	101606018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101606018G>A	ENST00000284395.5	+	33	5767	c.5367G>A	c.(5365-5367)ttG>ttA	p.L1789L	LRRK1_ENST00000388948.3_Silent_p.L1792L|LRRK1_ENST00000532145.1_3'UTR|RP11-505E24.2_ENST00000559857.1_RNA			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1792					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGCGGCCCTTGGACACGGAAC	0.642000													9	49					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33067568	33067568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33067568C>T	ENST00000374864.4	+	18	2005	c.1792C>T	c.(1792-1794)Cgt>Tgt	p.R598C	ITCH_ENST00000535650.1_Missense_Mutation_p.R488C|ITCH_ENST00000483727.1_3'UTR|ITCH_ENST00000262650.6_Missense_Mutation_p.R639C	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	639	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						GAAATATTTTCGTTTTATTGG	0.373000													9	99					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118764606	118764606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118764606G>A	ENST00000292174.4	+	2	529	c.353G>A	c.(352-354)gGg>gAg	p.G118E	BCL9L_ENST00000334801.3_3'UTR	NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	118					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TGGGTCCTGGGGACCTTCCTC	0.617000													26	57					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52282107	52282107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52282107G>A	ENST00000301190.6	+	1	364	c.137G>A	c.(136-138)cGa>cAa	p.R46Q	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_5'UTR|ANKRD33_ENST00000538991.1_5'UTR	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	0										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GATACCCTACGAACCCCAAGT	0.592000													18	44					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116548868	116548868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:116548868C>T	ENST00000410059.1	+	19	2116	c.1636C>T	c.(1636-1638)Cct>Tct	p.P546S	DPP10_ENST00000409163.1_Missense_Mutation_p.P496S|DPP10_ENST00000310323.8_Missense_Mutation_p.P539S|DPP10_ENST00000393147.2_Missense_Mutation_p.P550S	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	546					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AAAAGAACTTCCTTTACAGTT	0.313000													43	104					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50383659	50383659	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50383659G>A	ENST00000221543.5	+	4	618	c.319_splice	c.e4+1	p.G107_splice	TBC1D17_ENST00000598789.1_3'UTR|TBC1D17_ENST00000535102.2_Splice_Site_p.G74_splice	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	107						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GCCCACGAGAGGTAGGCTGAG	0.597000													18	32					0	0	1	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31488639	31488639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31488639C>T	ENST00000394863.3	+	11	1258	c.1128C>T	c.(1126-1128)ttC>ttT	p.F376F	TGFB1I1_ENST00000361773.3_Silent_p.F359F|TGFB1I1_ENST00000394858.2_Silent_p.F359F|TGFB1I1_ENST00000567607.1_Silent_p.F359F	NM_001042454.2	NP_001035919.1	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced transcript 1	376	LIM zinc-binding 3.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding	p.F376F(1)|p.F359F(1)		lung(8)|upper_aerodigestive_tract(1)	9						AGGAATGCTTCGCGCCCTTCT	0.662000													18	28					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493984	55493984	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55493984G>A	ENST00000543010.1	+	6	1061	c.918G>A	c.(916-918)ggG>ggA	p.G306G	NLRP2_ENST00000339757.7_Silent_p.G284G|NLRP2_ENST00000391721.4_Silent_p.G282G|NLRP2_ENST00000427260.2_Silent_p.G283G|NLRP2_ENST00000538819.1_Silent_p.G282G|NLRP2_ENST00000263437.6_Silent_p.G303G|NLRP2_ENST00000537859.1_Silent_p.G284G|NLRP2_ENST00000448584.2_Silent_p.G306G	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	306	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ACATCTGCGGGGACTGGGAGA	0.612000													25	53					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	981129	981129	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:981129C>T	ENST00000379370.2	+	15	2603	c.2553C>T	c.(2551-2553)ccC>ccT	p.P851P		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	851	Laminin EGF-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GCTGTGATCCCCAAGGCGCCG	0.657000													27	81					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32126220	32126220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32126220C>T	ENST00000373672.3	-	62	4361	c.3845G>A	c.(3844-3846)gGa>gAa	p.G1282E	COL16A1_ENST00000271069.6_Missense_Mutation_p.G1282E	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1282	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TCCCTGGGGTCCCATGGCACC	0.557000													25	88					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	168004397	168004397	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:168004397C>T	ENST00000357154.3	-	3	327	c.189_splice	c.e3-1	p.E64_splice	SPOCK3_ENST00000511269.1_Intron|SPOCK3_ENST00000541354.1_Intron|SPOCK3_ENST00000507137.1_Intron|SPOCK3_ENST00000504953.1_Intron|SPOCK3_ENST00000535728.1_Intron|SPOCK3_ENST00000511531.1_Intron|SPOCK3_ENST00000534949.1_Intron|SPOCK3_ENST00000357545.4_Intron|SPOCK3_ENST00000506886.1_Splice_Site_p.E64_splice|SPOCK3_ENST00000541637.1_Intron|SPOCK3_ENST00000512648.1_Intron|SPOCK3_ENST00000421836.2_Intron|SPOCK3_ENST00000512681.1_Intron|SPOCK3_ENST00000510741.1_Intron|SPOCK3_ENST00000502330.1_Intron	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	64					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		acctctacttcctcagacttt	0.468000													107	238					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24125836	24125836	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24125836G>A	ENST00000598975.1	-	1	309	c.310C>T	c.(310-312)Cag>Tag	p.Q104*	MMP11_ENST00000215743.3_3'UTR																							GCATGGGACTGAGCCCATGTC	0.632000													8	27					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174649	207174649	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207174649G>A	ENST00000374423.3	+	5	5783	c.5397G>A	c.(5395-5397)agG>agA	p.R1799R		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1799							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ATTCTGTAAGGAACCTGAAAA	0.408000													7	53					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7683931	7683931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7683931C>T	ENST00000256861.6	-	3	336	c.258G>A	c.(256-258)caG>caA	p.Q86Q	ITIH5_ENST00000446830.2_5'UTR|ITIH5_ENST00000397146.2_Silent_p.Q86Q|ITIH5_ENST00000397145.2_Silent_p.Q86Q	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	86	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						GAATCTGCATCTGGAACTCAA	0.483000													45	84					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943525	72943525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72943525G>A	ENST00000328801.4	+	6	1575	c.1575G>A	c.(1573-1575)agG>agA	p.R525R		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	525						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					GGAAGCGGAGGGCACTCAAGG	0.617000													15	44					0	0	1	0	0
GABRR1	2569	broad.mit.edu	37	6	89888625	89888625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:89888625G>A	ENST00000435811.1	-	9	1707	c.1253C>T	c.(1252-1254)tCc>tTc	p.S418F	GABRR1_ENST00000454853.2_Missense_Mutation_p.S435F|GABRR1_ENST00000369451.3_Missense_Mutation_p.S348F	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	435					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	CCTCTGTGGGGAGCTCCTCTC	0.512000													44	66					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124593205	124593205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124593205C>T	ENST00000368904.1	-	10	2583	c.1634G>A	c.(1633-1635)aGt>aAt	p.S545N	CUZD1_ENST00000392790.1_Missense_Mutation_p.S545N|CUZD1_ENST00000545804.1_Missense_Mutation_p.S545N			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	545					cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GCCACTTGCACTTCGATCCCT	0.393000													43	115					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241689931	241689931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241689931G>A	ENST00000498729.2	-	28	3138	c.2892C>T	c.(2890-2892)ccC>ccT	p.P964P	KIF1A_ENST00000320389.7_Silent_p.P863P	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	863					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CCAGGGGAACGGGGTACAGCA	0.657000													7	36					0	0	1	0	0
KCNG3	170850	broad.mit.edu	37	2	42720426	42720426	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:42720426G>A	ENST00000306078.1	-	1	811	c.216C>T	c.(214-216)ttC>ttT	p.F72F	KCNG3_ENST00000394973.4_Silent_p.F72F	NM_133329.5|NM_172344.2	NP_579875.1|NP_758847.1	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G, member 3	72						endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	6						AGAGCAGGATGAAGCCGAAGG	0.662000													13	25					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75065531	75065531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75065531C>T	ENST00000326665.5	-	11	1792	c.1574G>A	c.(1573-1575)gGa>gAa	p.G525E	C1orf173_ENST00000420661.2_Missense_Mutation_p.G328E|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	525	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTGCGGTATTCCATTCATTTG	0.388000													61	167					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32996178	32996178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32996178G>A	ENST00000070846.6	-	6	1472	c.1448C>T	c.(1447-1449)aCt>aTt	p.T483I	PKP2_ENST00000340811.4_Intron	NM_004572.3	NP_004563.2	Q99959	PKP2_HUMAN	plakophilin 2	483					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					gcctcccaaagtgctgggatt	0.512000													14	13					0	0	1	0	0
KRTAP9-4	85280	broad.mit.edu	37	17	39406380	39406380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39406380G>A	ENST00000334109.2	+	1	442	c.408G>A	c.(406-408)gaG>gaA	p.E136E		NM_033191.2	NP_149461.2	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	136	15 X 5 AA repeats of C-C-[RQVGE]-[SPTN]- [TASPF].					keratin filament				breast(1)|large_intestine(1)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCTGCTGTGAGACCACTTGCT	0.572000													75	83					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58598337	58598337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58598337C>T	ENST00000240727.6	-	5	1080	c.681G>A	c.(679-681)ggG>ggA	p.G227G	ZSCAN18_ENST00000600404.1_Silent_p.G283G|ZSCAN18_ENST00000601144.1_Silent_p.G227G|ZSCAN18_ENST00000421612.2_Silent_p.G92G	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	227					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCCCCACTCCCCCAGGTGCT	0.642000													10	48					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21069026	21069026	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21069026C>T	ENST00000381545.3	+	16	2173	c.1954C>T	c.(1954-1956)Caa>Taa	p.Q652*	SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000540229.1_Intron|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Nonsense_Mutation_p.Q652*|SLCO1B3_ENST00000553473.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	652					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					GAAAAAATTTCAAGGAAAAGA	0.333000													17	33					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100127991	100127991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:100127991C>T	ENST00000395996.1	+	7	937	c.826C>T	c.(826-828)Cgt>Tgt	p.R276C	VPS13B_ENST00000358544.2_Missense_Mutation_p.R276C|VPS13B_ENST00000441350.2_Missense_Mutation_p.R276C|VPS13B_ENST00000355155.1_Missense_Mutation_p.R276C|VPS13B_ENST00000357162.2_Missense_Mutation_p.R276C			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	276					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TATGTTTATTCGTATAATGCA	0.333000													10	93					0	0	1	0	0
IGSF11	152404	broad.mit.edu	37	3	118824028	118824028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:118824028C>T	ENST00000354673.2	-	3	392	c.12G>A	c.(10-12)gtG>gtA	p.V4V	IGSF11_ENST00000441144.2_Silent_p.V4V|IGSF11_ENST00000425327.2_Silent_p.V4V	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	0					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GCAAAAGTTCCACCAGAGACA	0.348000													14	78					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40231732	40231732	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:40231732G>A	ENST00000302541.6	+	10	1785	c.1443G>A	c.(1441-1443)agG>agA	p.R481R	MYRIP_ENST00000444716.1_Silent_p.R481R|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Silent_p.R392R|MYRIP_ENST00000539167.1_Silent_p.R294R|MYRIP_ENST00000425621.1_Silent_p.R481R	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	481	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		AGGCCCCCAGGAACCCTGCAG	0.632000													27	87					0	0	1	0	0
DHRS7C	201140	broad.mit.edu	37	17	9674963	9674963	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:9674963C>T	ENST00000330255.4	-	6	793	c.781G>A	c.(781-783)Gag>Aag	p.E261K	DHRS7C_ENST00000571134.1_Missense_Mutation_p.E260K	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	261						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						CGCATCACCTCCTCCGCCACC	0.622000													11	10					0	0	1	0	0
CALU	813	broad.mit.edu	37	7	128388731	128388731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128388731C>T	ENST00000535623.1	+	3	1061	c.118C>T	c.(118-120)Cct>Tct	p.P40S	CALU_ENST00000449187.2_Missense_Mutation_p.P32S|CALU_ENST00000535011.2_Missense_Mutation_p.P32S|CALU_ENST00000538546.1_Intron|CALU_ENST00000479257.1_Missense_Mutation_p.P40S|CALU_ENST00000249364.4_Missense_Mutation_p.P32S|CALU_ENST00000542996.2_Missense_Mutation_p.P40S	NM_001199671.1	NP_001186600.1	O43852	CALU_HUMAN	calumenin	32					platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding			kidney(2)|large_intestine(3)|lung(5)	10						ACATCATGAGCCTCAGCTCAG	0.468000													37	82					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170940958	170940958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:170940958C>T	ENST00000367759.4	+	8	704	c.550C>T	c.(550-552)Ccc>Tcc	p.P184S	MROH9_ENST00000367758.3_Missense_Mutation_p.P184S	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		CCATGAAGATCCCTCGATTGT	0.438000													81	223					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16908680	16908680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16908680C>T	ENST00000524140.2	+	16	3860	c.3442C>T	c.(3442-3444)Ctt>Ttt	p.L1148F	NWD1_ENST00000523826.1_Missense_Mutation_p.L942F|NWD1_ENST00000379808.3_Missense_Mutation_p.L1148F|NWD1_ENST00000552788.1_Missense_Mutation_p.L1148F|NWD1_ENST00000339803.6_Missense_Mutation_p.L1013F|NWD1_ENST00000549814.1_Missense_Mutation_p.L1148F	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1148							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CACGGGGTCCCTTGATGCGCT	0.517000													66	231					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29122786	29122786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29122786G>A	ENST00000261590.8	+	14	2514	c.2305G>A	c.(2305-2307)Gaa>Aaa	p.E769K	RP11-75N4.2_ENST00000583706.1_RNA	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	769					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TGCACTGAACGAAGAATTCTT	0.478000													23	72					0	0	1	0	0
FBXL15	79176	broad.mit.edu	37	10	104182012	104182012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104182012C>T	ENST00000224862.3	+	3	1992	c.676C>T	c.(676-678)Ctc>Ttc	p.L226F	FBXL15_ENST00000369956.2_Missense_Mutation_p.L222F	NM_024326.3	NP_077302.3	Q9H469	FXL15_HUMAN	F-box and leucine-rich repeat protein 15	226	Interaction with SMURF1.				bone mineralization|dorsal/ventral pattern formation|G2/M transition of mitotic cell cycle|positive regulation of BMP signaling pathway|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding			kidney(1)	1		Colorectal(252;0.207)		Epithelial(162;1.19e-08)|all cancers(201;2.65e-07)		CCACCTTGACCTCACCGGCTG	0.672000													3	13					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71909718	71909718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71909718C>T	ENST00000258104.3	+	54	6392	c.6115C>T	c.(6115-6117)Ctg>Ttg	p.L2039L	DYSF_ENST00000410041.1_Silent_p.L2057L|DYSF_ENST00000429174.2_Silent_p.L2060L|DYSF_ENST00000409744.1_Silent_p.L2047L|DYSF_ENST00000410020.3_Silent_p.L2078L|DYSF_ENST00000394120.2_Silent_p.L2040L|DYSF_ENST00000409366.1_Silent_p.L2061L|DYSF_ENST00000409582.3_Silent_p.L2077L|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Silent_p.L2070L|DYSF_ENST00000409651.1_Silent_p.L2071L|DYSF_ENST00000409762.1_Silent_p.L2056L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	2039						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GAAGTTCATCCTGTGGCGGCG	0.572000													43	91					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780368	37780368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37780368G>A	ENST00000447769.1	+	4	662	c.373G>A	c.(373-375)Gaa>Aaa	p.E125K	EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000334425.1_Missense_Mutation_p.E125K|GPR141_ENST00000461610.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	125						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AGACAAAGTGGAATTCTACAG	0.498000													35	144					0	0	1	0	0
CBX8	57332	broad.mit.edu	37	17	77769234	77769234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:77769234G>A	ENST00000269385.4	-	5	487	c.370C>T	c.(370-372)Ctt>Ttt	p.L124F	CBX8_ENST00000485449.1_5'UTR	NM_020649.2	NP_065700.1	Q9HC52	CBX8_HUMAN	chromobox homolog 8	124					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)	14			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			ATGTTTCGAAGGCCCTCCCGG	0.682000													8	10					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98146820	98146820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98146820G>A	ENST00000357947.3	-	14	1967	c.1742C>T	c.(1741-1743)tCc>tTc	p.S581F		NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	581	EGF-like 1; calcium-binding (Potential).			EVDECSWPDHGGCEHRCV -> GKKKKKKKKKKKKKKKKK (in Ref. 5; AAH13871).	cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		ATCTGGCCAGGAACACTCATC	0.597000													21	54					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47379867	47379867	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47379867C>T	ENST00000285039.7	-	31	4472	c.4173G>A	c.(4171-4173)gtG>gtA	p.V1391V	MYO5B_ENST00000324581.6_Silent_p.V506V	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1391					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CGCCGAATTCCACCTGGGCCT	0.567000													35	70					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73636695	73636695	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:73636695C>T	ENST00000377687.4	+	2	1494	c.958C>T	c.(958-960)Cag>Tag	p.Q320*	KLF5_ENST00000539231.1_Nonsense_Mutation_p.Q229*|KLF5_ENST00000477333.1_3'UTR	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	320					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		AGAGATGCTCCAGAATTTAAC	0.473000													36	140					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48813009	48813009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48813009G>A	ENST00000316623.5	-	10	1449	c.994C>T	c.(994-996)Cgc>Tgc	p.R332C		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	332					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TATCCTGGGCGAACATCTGAG	0.517000													22	53					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27948152	27948152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27948152C>T	ENST00000374005.3	-	5	634	c.346G>A	c.(346-348)Gag>Aag	p.E116K	FGR_ENST00000399173.1_Missense_Mutation_p.E116K|FGR_ENST00000374004.1_Missense_Mutation_p.E116K|FGR_ENST00000545953.1_Intron	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	116	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GACCGAGCCTCCCACCAGTCA	0.592000													27	70					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50546780	50546780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50546780C>T	ENST00000267845.3	-	5	925	c.523G>A	c.(523-525)Gat>Aat	p.D175N	HDC_ENST00000543581.1_Missense_Mutation_p.D175N	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	175					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TCATCAGCATCGGGCTCAGAC	0.547000													26	50					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210857051	210857051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210857051C>T	ENST00000367007.4	-	11	2630	c.2461G>A	c.(2461-2463)Gag>Aag	p.E821K	KCNH1_ENST00000271751.4_Missense_Mutation_p.E848K	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	848					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TTCCAGTCCTCACTCTTCCCG	0.612000													38	97					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17787380	17787380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:17787380C>T	ENST00000380607.4	+	5	454	c.334C>T	c.(334-336)Cca>Tca	p.P112S	SH3GL2_ENST00000537391.1_Missense_Mutation_p.P65S	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	112	BAR.|Binds and tubulates liposomes (By similarity).				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		TCTCCTAGGCCCAGCACTTGG	0.468000													13	131					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160915041	160915041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160915041G>A	ENST00000368029.3	-	8	924	c.867C>T	c.(865-867)ccC>ccT	p.P289P	ITLN2_ENST00000494442.1_5'UTR|RP11-544M22.1_ENST00000356006.3_RNA	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	289					signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CACACTGACGGGGTTTGCCCT	0.532000													22	37					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354341	45354341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45354341C>T	ENST00000359271.2	+	2	916	c.666C>T	c.(664-666)ttC>ttT	p.F222F		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	222						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				TGGACCTCTTCAGGGCACGCG	0.627000													31	86					0	0	1	0	0
TULP3	7289	broad.mit.edu	37	12	3040254	3040254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:3040254C>T	ENST00000448120.2	+	6	595	c.544C>T	c.(544-546)Ctg>Ttg	p.L182L	TULP3_ENST00000397132.2_Silent_p.L182L	NM_003324.4	NP_003315.2	O75386	TULP3_HUMAN	tubby like protein 3	182					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding			endometrium(1)|large_intestine(4)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			TGATAACCTCCTGGGAGACAT	0.512000													38	86					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457945	45457945	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45457945G>A	ENST00000548424.1	+	0	448																											TCACTCTGAGGAATTTCTCTT	0.428000													8	93					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427641	119427641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119427641G>A	ENST00000369429.3	-	8	1532	c.1523C>T	c.(1522-1524)gCc>gTc	p.A508V	TBX15_ENST00000207157.3_Missense_Mutation_p.A402V			Q96SF7	TBX15_HUMAN	T-box 15	508						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AAGGGAGAAGGCATTGTAGGA	0.537000													13	38					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175471	57175471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57175471C>T	ENST00000537055.2	-	2	1327	c.1096G>A	c.(1096-1098)Gac>Aac	p.D366N		NM_001005850.2	NP_001005850.2			zinc finger protein 835									p.D388N(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						TTGCCGCAGTCGTGGCAGGGG	0.701000													12	14					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79363156	79363156	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79363156G>A	ENST00000444841.1	-	0	1182																											AATGTCCCAGGATTTGTAGGA	0.517000													6	24					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2217047	2217047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2217047C>T	ENST00000398665.3	+	21	2538	c.2502C>T	c.(2500-2502)tcC>tcT	p.S834S		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	834						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCCCTGTCCCCTGGGGCCT	0.677000													16	42					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30926323	30926323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30926323G>A	ENST00000383096.3	-	9	692	c.510C>T	c.(508-510)gcC>gcT	p.A170A	CCDC178_ENST00000406524.2_Silent_p.A170A|CCDC178_ENST00000300227.8_Silent_p.A170A|CCDC178_ENST00000579947.1_Silent_p.A170A|CCDC178_ENST00000402325.1_Silent_p.A170A|CCDC178_ENST00000583930.1_Silent_p.A170A|CCDC178_ENST00000403303.1_Silent_p.A170A|CCDC178_ENST00000579916.1_Intron					coiled-coil domain containing 178																		TGAGACGAATGGCCTCTGAGA	0.338000													34	91					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104948883	104948883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:104948883G>A	ENST00000507740.1	+	10	2092	c.1856G>A	c.(1855-1857)cGa>cAa	p.R619Q	RIMS2_ENST00000262231.10_Missense_Mutation_p.R666Q|RIMS2_ENST00000406091.3_Missense_Mutation_p.R827Q|RIMS2_ENST00000436393.2_Missense_Mutation_p.R605Q	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	889					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TTTCGGGAACGAATGCTAGAG	0.383000										HNSCC(12;0.0054)			14	168					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6649939	6649939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6649939C>T	ENST00000299441.3	-	13	5695	c.5284G>A	c.(5284-5286)Gag>Aag	p.E1762K		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1762	Cadherin 17.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCTGGCCCTCAGGCACCTCC	0.572000													7	93					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	182994669	182994669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:182994669G>A	ENST00000328913.3	-	15	2150	c.1853C>T	c.(1852-1854)tCc>tTc	p.S618F	MCF2L2_ENST00000414362.2_Missense_Mutation_p.S618F|MCF2L2_ENST00000447025.2_Missense_Mutation_p.S618F|MCF2L2_ENST00000473233.1_Missense_Mutation_p.S618F	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	618					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.S618F(1)		breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CCTGCGGGGGGAAAGGTCTCC	0.557000													8	15					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58302915	58302915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:58302915C>T	ENST00000249750.4	-	4	1192	c.425G>A	c.(424-426)gGc>gAc	p.G142D	ALDH1A2_ENST00000537372.1_Missense_Mutation_p.G121D|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.G113D|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.G46D|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.G142D	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	142					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTTGATGACGCCCTGCAAATC	0.428000													22	51					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200877935	200877935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200877935G>A	ENST00000367342.4	+	7	1107	c.907G>A	c.(907-909)Ggt>Agt	p.G303S	C1orf106_ENST00000413687.2_Missense_Mutation_p.G218S	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	303	Pro-rich.									endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						AACCCTTGAGGGTCTGCAGCC	0.602000													51	104					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14812906	14812906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14812906C>T	ENST00000380881.4	-	17	3615	c.2800G>A	c.(2800-2802)Gaa>Aaa	p.E934K	FREM1_ENST00000380880.3_Missense_Mutation_p.E933K|FREM1_ENST00000422223.2_Missense_Mutation_p.E933K			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	933					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TGCTGAGGTTCGCGAGCAATC	0.478000													72	136					0	0	1	0	0
UBE2W	55284	broad.mit.edu	37	8	74722759	74722759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:74722759G>A	ENST00000517608.1	-	4	403	c.403C>T	c.(403-405)Caa>Taa	p.Q135*	UBE2W_ENST00000602593.1_Nonsense_Mutation_p.Q106*|UBE2W_ENST00000453587.2_Nonsense_Mutation_p.Q106*|UBE2W_ENST00000602969.1_Nonsense_Mutation_p.Q117*|UBE2W_ENST00000419880.3_Nonsense_Mutation_p.Q146*|RP11-463D19.2_ENST00000358757.5_Nonsense_Mutation_p.Q106*			Q96B02	UBE2W_HUMAN	ubiquitin-conjugating enzyme E2W (putative)	106					protein K11-linked ubiquitination|protein monoubiquitination		ATP binding|protein binding|ubiquitin-protein ligase activity			kidney(1)|lung(1)	2	Breast(64;0.0311)		Epithelial(68;0.0235)|all cancers(69;0.0687)|BRCA - Breast invasive adenocarcinoma(89;0.069)			CAAACTGATTGGACTGAGAGC	0.378000													30	83					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10104446	10104446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10104446C>T	ENST00000264828.3	-	17	1709	c.1624G>A	c.(1624-1626)Ggg>Agg	p.G542R		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	542	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent	p.G542R(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CCAGTGTCCCCTGGGAGGCCC	0.582000													41	98					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196771386	196771386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196771386C>T	ENST00000312428.6	-	27	4432	c.4332G>A	c.(4330-4332)ctG>ctA	p.L1444L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1444	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCATACCTTCAGGTTATCTG	0.388000													41	96					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178409938	178409938	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178409938G>A	ENST00000231188.5	-	9	2587	c.2409C>T	c.(2407-2409)ttC>ttT	p.F803F	GRM6_ENST00000517717.1_Silent_p.F803F|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	803					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CAGTGCCAAAGAAGATGGGCA	0.562000													34	58					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38433628	38433628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38433628C>T	ENST00000356264.2	-	18	1800	c.1585G>A	c.(1585-1587)Gag>Aag	p.E529K	AMPH_ENST00000428293.2_Missense_Mutation_p.E487K|AMPH_ENST00000325590.5_Missense_Mutation_p.E487K|AMPH_ENST00000471913.1_5'UTR	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	529					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						GCTTCGAGCTCCTCTGCTTCA	0.572000													28	130					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	82147811	82147811	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:82147811G>A	ENST00000550584.2	-	2	485	c.190C>T	c.(190-192)Cag>Tag	p.Q64*	PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.Q64*|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.Q64*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.Q64*|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.Q64*|PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.Q64*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	323										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ATGACATCCTGAAGTCTTTGC	0.483000													4	36					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3674315	3674315	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3674315G>A	ENST00000344754.4	-	13	3286	c.3287C>T	c.(3286-3288)aCc>aTc	p.T1096I	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.T1096I	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1096	Ig-like C2-type 11.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CTCCCGCACGGTAGCCCCGGG	0.647000													10	30					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760277	20760277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20760277C>T	ENST00000400451.2	+	5	1468	c.954C>T	c.(952-954)tcC>tcT	p.S318S	ZNF74_ENST00000405993.1_Silent_p.S286S|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Silent_p.S318S	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	318					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCACTCGTCCCTCAACGTGC	0.657000													35	79					0	0	1	0	0
AOC3	8639	broad.mit.edu	37	17	41003708	41003708	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:41003708G>A	ENST00000308423.2	+	1	508	c.348G>A	c.(346-348)ggG>ggA	p.G116G		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	116					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	TGGACAGGGGGAGCCCCCCAC	0.667000													22	31					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142643344	142643344	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142643344G>A	ENST00000355265.2	-	11	1738	c.1264C>T	c.(1264-1266)Ctg>Ttg	p.L422L	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	422					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AAAGCCGCCAGCGTGGGCTCG	0.592000													4	44					0	0	1	0	0
IARS2	55699	broad.mit.edu	37	1	220307845	220307845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:220307845C>T	ENST00000366922.1	+	15	2054	c.1723C>T	c.(1723-1725)Cct>Tct	p.P575S	IARS2_ENST00000302637.5_Missense_Mutation_p.P647S			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	647					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	GAAGAGAGCACCTTATAAGTA	0.458000													20	75					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21217065	21217065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21217065G>A	ENST00000380216.1	-	1	245	c.240C>T	c.(238-240)ttC>ttT	p.F80F		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	80					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TCATCTCATGGAAGGCAGAGA	0.473000													61	119					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94376979	94376979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94376979C>T	ENST00000282020.4	+	11	1970	c.1712C>T	c.(1711-1713)gCt>gTt	p.A571V	GRID2_ENST00000510992.1_Missense_Mutation_p.A476V	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	571					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCTCTATGGGCTTGCATTGCT	0.478000													48	104					0	0	1	0	0
MAN1A1	4121	broad.mit.edu	37	6	119569512	119569512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:119569512C>T	ENST00000368468.3	-	6	1346	c.905G>A	c.(904-906)cGa>cAa	p.R302Q	MAN1A1_ENST00000368466.2_Missense_Mutation_p.R325Q	NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	302					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TGCTTTCTTTCGAAAAATCTG	0.348000													19	38					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232561373	232561373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:232561373G>A	ENST00000366630.1	-	17	4950	c.4592C>T	c.(4591-4593)cCg>cTg	p.P1531L	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.P1531L|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.P605L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1531					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GTGGGCCCGCGGAGGCAGCGT	0.667000													9	15					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29562639	29562639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:29562639C>T	ENST00000358273.4	+	28	4102	c.3719C>T	c.(3718-3720)gCt>gTt	p.A1240V	NF1_ENST00000356175.3_Missense_Mutation_p.A1240V	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1240	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GATGAACTAGCTCGAGTTCTG	0.383000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			17	205					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110754783	110754783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110754783C>T	ENST00000369787.3	+	1	689	c.662C>T	c.(661-663)tCc>tTc	p.S221F	KCNC4_ENST00000412512.2_3'UTR|KCNC4_ENST00000438661.2_Missense_Mutation_p.S221F|KCNC4_ENST00000413138.3_Missense_Mutation_p.S221F	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	221					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		GATCCCTACTCCTCCCGGGCC	0.736000													5	9					0	0	1	0	0
SLC41A2	84102	broad.mit.edu	37	12	105199034	105199034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:105199034G>A	ENST00000258538.3	-	10	1745	c.1618C>T	c.(1618-1620)Ccc>Tcc	p.P540S	SLC41A2_ENST00000549713.1_5'UTR	NM_032148.3	NP_115524.3	Q96JW4	S41A2_HUMAN	solute carrier family 41 (magnesium transporter), member 2	540						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	22						GTTAGGTAGGGGATGGAGAAA	0.463000													29	256					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729430	196729430	+	Nonsense_Mutation	SNP	G	G	A	rs115474479	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196729430G>A	ENST00000312428.6	-	41	7049	c.6949C>T	c.(6949-6951)Cga>Tga	p.R2317*		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2317	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R2317*(1)		NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATGGCAAATCGAAACAAGACA	0.443000													51	148					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3783164	3783164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3783164C>T	ENST00000310132.6	-	7	1034	c.636G>A	c.(634-636)cgG>cgA	p.R212R	MATK_ENST00000585778.1_Silent_p.R212R|MATK_ENST00000395045.2_Silent_p.R213R|MATK_ENST00000395040.2_Silent_p.R171R	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	212					cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCGTGTTTCCGCTTTGGTC	0.652000													19	80					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50055532	50055532	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50055532G>A	ENST00000281631.5	+	4	398	c.240G>A	c.(238-240)gaG>gaA	p.E80E	PARP8_ENST00000511363.2_Intron|PARP8_ENST00000505554.1_Silent_p.E59E|PARP8_ENST00000503750.2_Silent_p.E80E|PARP8_ENST00000514342.2_5'UTR|PARP8_ENST00000505697.2_Silent_p.E80E|PARP8_ENST00000514067.2_Silent_p.E80E	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	80						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				TTACTACAGAGCCAATACCAG	0.249000													9	102					0	0	1	0	0
KCNS1	3787	broad.mit.edu	37	20	43723679	43723679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43723679C>T	ENST00000306117.1	-	5	1809	c.1413G>A	c.(1411-1413)gaG>gaA	p.E471E	KCNS1_ENST00000537075.1_Silent_p.E471E	NM_002251.3	NP_002242.2	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	471						voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding			endometrium(1)|lung(3)|ovary(1)|stomach(1)	6		Myeloproliferative disorder(115;0.0122)				GCACGGCTGCCTCCAGAGCCT	0.577000													64	124					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107978025	107978025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107978025G>A	ENST00000372129.2	-	1	1626	c.1550C>T	c.(1549-1551)tCg>tTg	p.S517L		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	517						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GTTTCCTCCCGAGCTATGGCT	0.597000													40	61					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20329723	20329723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20329723C>T	ENST00000302555.5	-	7	1186	c.1037G>A	c.(1036-1038)gGa>gAa	p.G346E	GP2_ENST00000341642.5_Missense_Mutation_p.G199E|GP2_ENST00000381360.5_Missense_Mutation_p.G202E|GP2_ENST00000381362.4_Missense_Mutation_p.G349E|GP2_ENST00000573897.1_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	349	ZP.					anchored to membrane|extracellular region|plasma membrane		p.G346E(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AATGAACTCTCCATTCCCGTC	0.473000													14	159					0	0	1	0	0
NEK3	4752	broad.mit.edu	37	13	52718862	52718862	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52718862G>A	ENST00000452082.2	-	8	2061	c.831C>T	c.(829-831)atC>atT	p.I277I	NEK3_ENST00000378101.2_Silent_p.I256I|NEK3_ENST00000339406.3_Silent_p.I256I|NEK3_ENST00000400357.2_Silent_p.I256I			P51956	NEK3_HUMAN	NIMA-related kinase 3	256	Interaction with VAV2.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|stomach(2)	18		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		GCCGAGCTACGATGCCTCGAG	0.463000													9	32					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79121182	79121182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:79121182C>T	ENST00000370747.4	+	5	911	c.826C>T	c.(826-828)Cgt>Tgt	p.R276C	IFI44_ENST00000495254.1_3'UTR|IFI44_ENST00000545124.1_5'UTR	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	276					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						CGGTAACATTCGTGATAGATA	0.353000													11	74					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29012450	29012450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29012450C>T	ENST00000282397.4	-	4	672	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	FLT1_ENST00000541932.1_Missense_Mutation_p.E141K|FLT1_ENST00000539099.1_Missense_Mutation_p.E141K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	141					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TCGGGGATTTCACTGTACATC	0.373000													15	42					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36679919	36679919	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36679919G>A	ENST00000265113.4	+	7	1527	c.1051G>A	c.(1051-1053)Ggg>Agg	p.G351R	SLC1A3_ENST00000381918.3_Missense_Mutation_p.G351R|CTD-2353F22.1_ENST00000510740.1_RNA	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	351					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TTTTATTGGAGGGTTGCTGCA	0.483000													30	58					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424752	125424752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125424752G>A	ENST00000373686.1	+	1	908	c.908G>A	c.(907-909)gGa>gAa	p.G303E				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						CTGTTTTATGGAAGCATTAGC	0.423000													55	166					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10443963	10443963	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10443963C>T	ENST00000245503.5	-	11	1340	c.956G>A	c.(955-957)gGg>gAg	p.G319E	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.G319E|MYH2_ENST00000532183.1_Missense_Mutation_p.G319E	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	319	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ACTGATCTCCCCTTGACTGAC	0.383000													8	28					0	0	1	0	0
CD300LB	124599	broad.mit.edu	37	17	72522000	72522000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72522000G>A	ENST00000392621.1	-	2	372	c.368C>T	c.(367-369)aCg>aTg	p.T123M	CD300LB_ENST00000314401.3_Missense_Mutation_p.T123M	NM_174892.2	NP_777552.2	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	86						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(1)	21						CACAGTGAACGTGCGGTCTTT	0.522000													65	134					0	0	1	0	0
HRH3	11255	broad.mit.edu	37	20	60791598	60791598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60791598C>T	ENST00000340177.5	-	3	1086	c.802G>A	c.(802-804)Gag>Aag	p.E268K	HRH3_ENST00000317393.6_Missense_Mutation_p.E268K	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	268					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	GGCATGGCCTCCCCGTGCCCC	0.776000													5	7					0	0	1	0	0
RNASE3	6037	broad.mit.edu	37	14	21359902	21359902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21359902G>A	ENST00000304639.3	+	2	115	c.57G>A	c.(55-57)atG>atA	p.M19I		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	19					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	TGGGGCTTATGGGTGTGGAGG	0.512000													66	149					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45451937	45451937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45451937C>T	ENST00000331493.2	+	12	1388	c.977C>T	c.(976-978)tCt>tTt	p.S326F	EFCAB13_ENST00000517484.1_Missense_Mutation_p.S230F	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		AATAGTTTGTCTTCCAAACTC	0.303000													29	42					0	0	1	0	0
ALKBH1	8846	broad.mit.edu	37	14	78142163	78142163	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:78142163G>A	ENST00000216489.3	-	5	591	c.576C>T	c.(574-576)ttC>ttT	p.F192F		NM_006020.2	NP_006011.2	Q13686	ALKB1_HUMAN	alkB, alkylation repair homolog 1 (E. coli)	192					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		GGTCAGAAGGGAAAGGTGTGT	0.418000													18	60					0	0	1	0	0
IP6K2	51447	broad.mit.edu	37	3	48727117	48727117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48727117G>A	ENST00000328631.5	-	5	857	c.634C>T	c.(634-636)Cgc>Tgc	p.R212C		NM_001005909.2|NM_016291.3	NP_001005909.1|NP_057375.2	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	212					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						ACCTCGTAGCGGGAAGTCAGG	0.478000													23	45					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101845424	101845424	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101845424C>T	ENST00000360264.3	+	18	2900	c.2880C>T	c.(2878-2880)acC>acT	p.T960T	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292535.7_Silent_p.T949T|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000556210.1_Silent_p.T791T|CUX1_ENST00000550008.2_Silent_p.T893T|CUX1_ENST00000549414.2_Silent_p.T927T|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Silent_p.T847T	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	949					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCGAGCTCACCCGGCAGGTTA	0.597000													12	139					0	0	1	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067202	18067202	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18067202C>T	ENST00000506618.2	-	1	284	c.204G>A	c.(202-204)atG>atA	p.M68I		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	68					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TCAAAAGCTCCATTAGACTGT	0.478000													102	278					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235148	5235148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:5235148C>T	ENST00000274181.7	+	13	2010	c.1872C>T	c.(1870-1872)ttC>ttT	p.F624F		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	624	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						GAGGGAAGTTCTGTGAGGGCT	0.448000													25	62					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121293253	121293253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121293253C>T	ENST00000297848.3	+	31	4049	c.3779C>T	c.(3778-3780)cCa>cTa	p.P1260L	COL14A1_ENST00000309791.4_Missense_Mutation_p.P1260L|COL14A1_ENST00000247781.3_Missense_Mutation_p.P1165L	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1260	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATGTGTTTCCATGTTACCAA	0.368000													23	111					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129070689	129070689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:129070689G>A	ENST00000274487.4	+	22	3504	c.3359G>A	c.(3358-3360)gGa>gAa	p.G1120E	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1120	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AAGATCACAGGAAGACATGGA	0.388000													25	77					0	0	1	0	0
CMTM5	116173	broad.mit.edu	37	14	23846556	23846556	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23846556C>T	ENST00000359320.3	+	1	540	c.96C>T	c.(94-96)tcC>tcT	p.S32S	CMTM5_ENST00000342473.4_Silent_p.S32S|CMTM5_ENST00000397227.3_Silent_p.S32S|CMTM5_ENST00000382809.2_Silent_p.S32S|CMTM5_ENST00000339180.4_Silent_p.S32S|CMTM5_ENST00000555731.1_Silent_p.S32S	NM_138460.2	NP_612469.1	Q96DZ9	CKLF5_HUMAN	CKLF-like MARVEL transmembrane domain containing 5	32	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	8	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		TCCTCACCTCCCACAAGGGCA	0.647000													17	67					0	0	1	0	0
AQP9	366	broad.mit.edu	37	15	58430764	58430764	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:58430764G>A	ENST00000219919.4	+	0	370				AQP9_ENST00000558772.1_Intron|ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000536493.1_De_novo_Start_InFrame|AQP9_ENST00000559443.1_3'UTR	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9						cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		GAAGCCCCAAGATGCAGCCTG	0.488000													12	35					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1270929	1270929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1270929G>A	ENST00000447027.1	+	31	12886	c.12828G>A	c.(12826-12828)ccG>ccA	p.P4276P	MUC5B_ENST00000529681.1_Silent_p.P4273P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4273	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCTCCACCCCGGGAACAGCTC	0.637000													24	154					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	13935508	13935508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:13935508C>T	ENST00000343495.5	-	13	2101	c.1363G>A	c.(1363-1365)Gaa>Aaa	p.E455K	ETV1_ENST00000403685.1_Missense_Mutation_p.E455K|ETV1_ENST00000399357.3_Missense_Mutation_p.E370K|ETV1_ENST00000403527.1_Missense_Mutation_p.E433K|ETV1_ENST00000405192.2_Missense_Mutation_p.E450K|ETV1_ENST00000242066.5_Missense_Mutation_p.E455K|ETV1_ENST00000430479.1_Missense_Mutation_p.E473K|ETV1_ENST00000405358.4_Missense_Mutation_p.E487K|ETV1_ENST00000420159.2_Missense_Mutation_p.E415K|ETV1_ENST00000405218.2_Missense_Mutation_p.E473K			P50549	ETV1_HUMAN	ets variant 1	473					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E473K(1)	TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						ACGTAGCCTTCGTTGTAGGGG	0.478000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								8	19					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14489121	14489121	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14489121C>T	ENST00000454876.2	+	5	725	c.396C>T	c.(394-396)tcC>tcT	p.S132S	SLC6A6_ENST00000360861.3_Silent_p.S132S|SLC6A6_ENST00000484191.1_3'UTR|SLC6A6_ENST00000416216.2_Silent_p.S132S			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	132					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						TAATTGTGTCCCTCCTGAATG	0.542000													47	577					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84270636	84270636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:84270636G>A	ENST00000428679.2	-	27	3066	c.2473C>T	c.(2473-2475)Cct>Tct	p.P825S	SNAP91_ENST00000521485.1_Missense_Mutation_p.P820S|SNAP91_ENST00000439399.2_Missense_Mutation_p.P825S|SNAP91_ENST00000195649.6_Missense_Mutation_p.P820S|SNAP91_ENST00000369694.2_Missense_Mutation_p.P825S|SNAP91_ENST00000521743.1_Missense_Mutation_p.P825S|SNAP91_ENST00000437520.1_Missense_Mutation_p.P518S|SNAP91_ENST00000520213.1_Missense_Mutation_p.P518S|SNAP91_ENST00000520302.1_Missense_Mutation_p.P795S			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	825	Pro-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GCAACAGGAGGAACTGAACTG	0.423000													14	11					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171264339	171264339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171264339C>T	ENST00000334231.6	+	22	2662	c.2662C>T	c.(2662-2664)Cct>Tct	p.P888S	MYO3B_ENST00000408978.4_Missense_Mutation_p.P879S|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000409044.3_Missense_Mutation_p.P879S			Q8WXR4	MYO3B_HUMAN	myosin IIIB	879	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						CTTCTCAATCCCTCTGACCAA	0.463000													57	148					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52852284	52852284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52852284G>A	ENST00000266041.4	-	19	2264	c.2168C>T	c.(2167-2169)aCc>aTc	p.T723I	ITIH4_ENST00000485816.1_Missense_Mutation_p.T728I|ITIH4_ENST00000406595.1_Missense_Mutation_p.T693I|ITIH4_ENST00000346281.5_Missense_Mutation_p.T693I	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	723					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TGGGGTTTGGGTTGTCATGGT	0.597000													11	65					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807339	143807339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143807339G>A	ENST00000408979.2	+	1	733	c.664G>A	c.(664-666)Ggg>Agg	p.G222R		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					GCACATCCTCGGGGCCATCCT	0.517000													61	136					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74595936	74595936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74595936G>A	ENST00000361874.3	-	16	2090	c.1773C>T	c.(1771-1773)ttC>ttT	p.F591F	DCTN1_ENST00000407639.2_Silent_p.F457F|DCTN1_ENST00000409567.3_Silent_p.F571F|DCTN1_ENST00000394003.3_Silent_p.F584F|DCTN1_ENST00000409438.1_Silent_p.F457F|DCTN1_ENST00000409240.1_Silent_p.F554F|DCTN1_ENST00000409868.1_Silent_p.F574F	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	591					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						TGTCAGGCATGAAGGCTGTCA	0.547000													26	78					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249993	52249993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52249993C>T	ENST00000595042.1	-	3	396	c.255G>A	c.(253-255)aaG>aaA	p.K85K	FPR1_ENST00000304748.4_Silent_p.K85K	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	85					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CTCCCATGGCCTTCCTGACCA	0.512000													11	104					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396858	154396858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154396858C>T	ENST00000435029.4	+	1	3599	c.3439C>T	c.(3439-3441)Cct>Tct	p.P1147S		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1147	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACTGGAGGATCCTACCGAGGT	0.542000													38	62					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179499268	179499268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179499268C>T	ENST00000589042.1	-	230	42464	c.42240G>A	c.(42238-42240)gaG>gaA	p.E14080E	TTN_ENST00000342992.6_Silent_p.E11512E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.E12439E|TTN_ENST00000342175.6_Silent_p.E5207E|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.E5140E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.E5015E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12439	Fibronectin type-III 1.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACATTTGCCTCTCGGGTGA	0.398000													50	131					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25708275	25708275	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:25708275T>A	ENST00000520164.1	-	15	2068	c.1531A>T	c.(1531-1533)Atg>Ttg	p.M511L	EBF2_ENST00000408929.3_Missense_Mutation_p.M363L|EBF2_ENST00000535548.1_3'UTR	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	511	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		CTTGATGACATGACTGGAAAG	0.423000													20	45					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926127	70926127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70926127G>A	ENST00000603540.1	+	2	2169	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Silent_p.E637E	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	637	EGF-like.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCCTTCCTGAGACCTGCAATA	0.507000													26	65					0	0	1	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20077862	20077862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:20077862C>T	ENST00000276390.2	+	14	1525	c.1485C>T	c.(1483-1485)atC>atT	p.I495I		NM_001693.3	NP_001684.2	P21281	VATB2_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	495					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(1)|kidney(2)|lung(5)|prostate(1)	9				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TGAAGAGAATCCCTCAGAGCA	0.463000													26	103					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25228586	25228586	+	Missense_Mutation	SNP	G	G	A	rs61733055	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:25228586G>A	ENST00000219660.5	+	2	205	c.80G>A	c.(79-81)cGa>cAa	p.R27Q	AQP8_ENST00000566125.1_Missense_Mutation_p.R21Q	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	27					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		GGCAGGTGGCGAGTGTCCTGG	0.577000													63	245					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171406482	171406482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:171406482G>A	ENST00000356327.5	-	14	1593	c.1523C>T	c.(1522-1524)tCt>tTt	p.S508F	PLD1_ENST00000342215.6_Missense_Mutation_p.S508F|PLD1_ENST00000340989.4_Missense_Mutation_p.S508F|PLD1_ENST00000351298.4_Missense_Mutation_p.S508F	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	508	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GGAACCCAGAGACGGTCCTGA	0.453000													9	82					0	0	1	0	0
WASF1	8936	broad.mit.edu	37	6	110423024	110423024	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110423024G>A	ENST00000392589.1	-	10	2125	c.1289C>T	c.(1288-1290)cCt>cTt	p.P430L	WASF1_ENST00000392587.2_Missense_Mutation_p.P430L|WASF1_ENST00000359451.2_Missense_Mutation_p.P430L|WASF1_ENST00000392586.1_Missense_Mutation_p.P430L|WASF1_ENST00000392588.1_Missense_Mutation_p.P430L	NM_003931.2	NP_003922.1	Q92558	WASF1_HUMAN	WAS protein family, member 1	430	Poly-Pro.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		AGGCAGAGGAGGCGGTGGTGG	0.572000													30	41					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49598400	49598400	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49598400C>T	ENST00000527477.1	+	0	1004																											AGGCAAGGTCCATGGTGGACA	0.443000													35	26					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119434453	119434453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119434453C>T	ENST00000273390.5	+	6	622	c.545C>T	c.(544-546)tCc>tTc	p.S182F	MAATS1_ENST00000463700.1_Missense_Mutation_p.S182F	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		AAGCACCTATCCATCCCTTCA	0.388000													83	227					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160114891	160114891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:160114891C>T	ENST00000327245.5	-	5	1037	c.191G>A	c.(190-192)aGg>aAg	p.R64K	ATP10B_ENST00000518411.1_5'UTR|CTC-529G1.1_ENST00000524198.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	64					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGGTATCTCCTGGAGACCTC	0.498000													14	210					0	0	1	0	0
PLEK2	26499	broad.mit.edu	37	14	67864445	67864445	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:67864445G>A	ENST00000216446.4	-	2	281	c.141C>T	c.(139-141)ccC>ccT	p.P47P		NM_016445.1	NP_057529.1	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	47	PH 1.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	15				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		TCCGGCCCTTGGGAGGGGTCA	0.602000													8	25					0	0	1	0	0
RHOXF2	84528	broad.mit.edu	37	X	119293315	119293315	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:119293315C>T	ENST00000371388.3	+	2	664	c.474C>T	c.(472-474)ttC>ttT	p.F158F		NM_032498.1	NP_115887.1	Q9BQY4	RHXF2_HUMAN	Rhox homeobox family, member 2	158						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|skin(2)	8						GCGAGCAGTTCCCCAGTGAGT	0.652000													9	5					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17743712	17743712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17743712C>T	ENST00000428389.2	-	29	3570	c.3571G>A	c.(3571-3573)Gac>Aac	p.D1191N	UNC13A_ENST00000551649.1_Missense_Mutation_p.D1103N|UNC13A_ENST00000552293.1_Missense_Mutation_p.D1103N|UNC13A_ENST00000252773.7_Missense_Mutation_p.D1103N|UNC13A_ENST00000519716.2_Missense_Mutation_p.D1103N|UNC13A_ENST00000550896.1_Missense_Mutation_p.D1101N			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1103	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CGATGCTTGTCGTGCTCTGGC	0.537000													17	38					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40743889	40743889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40743889C>T	ENST00000373198.3	-	23	3350	c.3115G>A	c.(3115-3117)Gaa>Aaa	p.E1039K	PTPRT_ENST00000373187.1_Missense_Mutation_p.E1017K|PTPRT_ENST00000373193.3_Missense_Mutation_p.E1020K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E1007K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E1027K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E1026K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E1016K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1017	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCTCTGTTTCAATCAGGGTG	0.532000													33	84					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95347003	95347003	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95347003C>T	ENST00000371483.4	+	4	827	c.771C>T	c.(769-771)ctC>ctT	p.L257L	FFAR4_ENST00000371481.4_Silent_p.L241L|FFAR4_ENST00000604414.1_Intron	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		GGAAGAGGCTCACGGTAAGCC	0.567000													26	53					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150881794	150881794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:150881794C>T	ENST00000474524.1	+	8	1260	c.1222C>T	c.(1222-1224)Ccc>Tcc	p.P408S	MED12L_ENST00000309237.4_Missense_Mutation_p.P408S|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000422248.2_Missense_Mutation_p.P408S	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	408					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTCCAGCCTCCCCATGCCGGG	0.522000													23	84					0	0	1	0	0
MAGEA5	4104	broad.mit.edu	37	X	151283670	151283670	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151283670C>T	ENST00000509345.2	-	0	666																											TGAATCAAGTCAGCCACCTTC	0.502000													10	66					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30433256	30433256	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30433256G>A	ENST00000375978.3	-	1	164	c.90C>T	c.(88-90)gcC>gcT	p.A30A		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	30					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						AGCTCTGGATGGCCATAGCAA	0.662000													24	91					0	0	1	0	0
PROSER2	254427	broad.mit.edu	37	10	11911750	11911750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11911750G>A	ENST00000277570.5	+	4	807	c.653G>A	c.(652-654)aGg>aAg	p.R218K	PROSER2-AS1_ENST00000453242.1_RNA|PROSER2_ENST00000379200.1_Missense_Mutation_p.R22K|PROSER2-AS1_ENST00000445498.1_RNA	NM_153256.3	NP_694988.3			proline and serine-rich protein 2																		TCCCCGTTCAGGGAGGGCCGG	0.731000													3	6					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	517373	517373	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:517373C>T	ENST00000453061.2	+	9	1846	c.1740C>T	c.(1738-1740)ttC>ttT	p.F580F	PIGG_ENST00000310340.5_Silent_p.F572F|PIGG_ENST00000383028.4_Silent_p.F447F|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000504346.1_Silent_p.F491F	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	580					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CCTGGTACTTCCTTGTGAACA	0.567000													54	119					0	0	1	0	0
DIRC1	116093	broad.mit.edu	37	2	189599363	189599363	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189599363C>T	ENST00000308100.4	-	2	555	c.285G>A	c.(283-285)tgG>tgA	p.W95*	AC079613.1_ENST00000431708.1_RNA	NM_052952.2	NP_443184.1	Q969H9	DIRC1_HUMAN	disrupted in renal carcinoma 1	95										large_intestine(1)|lung(6)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00842)|Epithelial(96;0.102)			TTAATATTTTCCACCCCCTCA	0.373000													57	153					0	0	1	0	0
TTC39A	22996	broad.mit.edu	37	1	51770760	51770760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:51770760C>T	ENST00000262676.5	-	8	903	c.743G>A	c.(742-744)gGa>gAa	p.G248E	TTC39A_ENST00000451380.1_Missense_Mutation_p.G216E|TTC39A_ENST00000447632.2_Missense_Mutation_p.G252E|TTC39A_ENST00000371750.5_Missense_Mutation_p.G217E|TTC39A_ENST00000371747.3_Missense_Mutation_p.G251E|TTC39A_ENST00000262675.7_Missense_Mutation_p.G189E|TTC39A_ENST00000413473.2_Missense_Mutation_p.G220E			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	252							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						TACCTTGTTTCCTGAAAACCC	0.582000													20	48					0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048319	6048319	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6048319G>A	ENST00000316650.5	-	1	652	c.616C>T	c.(616-618)Caa>Taa	p.Q206*		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCACAAATTGGTAGATTCTG	0.453000													31	99					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519127	113519127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113519127C>T	ENST00000284601.3	-	4	2088	c.2020G>A	c.(2020-2022)Gag>Aag	p.E674K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	674					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTGATATGCTCTGTTATGTTT	0.373000													58	272					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113703917	113703917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113703917C>T	ENST00000374431.3	-	4	960	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K	LPAR1_ENST00000538760.1_Missense_Mutation_p.E194K|LPAR1_ENST00000541779.1_Missense_Mutation_p.E194K|LPAR1_ENST00000374430.2_Missense_Mutation_p.E193K|LPAR1_ENST00000358883.4_Missense_Mutation_p.E193K	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	193					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						GAACAATTTTCAATATCACAG	0.483000													41	71					0	0	1	0	0
CXorf65	158830	broad.mit.edu	37	X	70325897	70325897	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70325897G>T	ENST00000374251.4	-	3	250	c.203C>A	c.(202-204)aCa>aAa	p.T68K	CXorf65_ENST00000485951.1_5'UTR			A6NEN9	CX065_HUMAN	chromosome X open reading frame 65	68										breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)	10						GCTTCGAGCTGTAAGGTATTT	0.473000													32	14					9.65021e-13	9.69639e-13	1	1	0
TDRD5	163589	broad.mit.edu	37	1	179603649	179603649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179603649C>T	ENST00000444136.1	+	8	1434	c.1184C>T	c.(1183-1185)tCa>tTa	p.S395L	TDRD5_ENST00000367614.1_Missense_Mutation_p.S395L|TDRD5_ENST00000294848.8_Missense_Mutation_p.S395L	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	395					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CCTAGAAATTCATTGTCTACT	0.388000													46	116					0	0	1	0	0
HTRA3	94031	broad.mit.edu	37	4	8307825	8307825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8307825G>A	ENST00000307358.2	+	9	1528	c.1324G>A	c.(1324-1326)Gac>Aac	p.D442N		NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	442	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						GGGGAACGACGACCTCCTCTT	0.657000													9	43					0	0	1	0	0
CDX1	1044	broad.mit.edu	37	5	149563070	149563070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149563070G>A	ENST00000231656.8	+	3	707	c.625G>A	c.(625-627)Gag>Aag	p.E209K		NM_001804.2	NP_001795.2	P47902	CDX1_HUMAN	caudal type homeobox 1	209						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|lung(1)|ovary(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCGGGCAAAGGAGCGCAAAGT	0.612000													15	34					0	0	1	0	0
PRG3	10394	broad.mit.edu	37	11	57146261	57146261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57146261C>T	ENST00000287143.2	-	4	509	c.400G>A	c.(400-402)Ggc>Agc	p.G134S		NM_006093.3	NP_006084.2	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3	134	C-type lectin.				basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding			large_intestine(3)|lung(5)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	13						ACAAGGTTGCCTCCGTAGCAT	0.488000													20	230					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43921516	43921516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43921516G>A	ENST00000336086.6	-	2	2260	c.24C>T	c.(22-24)ttC>ttT	p.F8F	URGCP_ENST00000447717.3_Silent_p.F8F|URGCP_ENST00000446958.1_Silent_p.F42F|URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000402306.3_Silent_p.F42F|URGCP_ENST00000453200.1_Silent_p.F51F|URGCP_ENST00000443736.1_Silent_p.F8F|RP5-1165K10.1_ENST00000603700.1_Silent_p.F42F|URGCP_ENST00000223341.7_Silent_p.F8F			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	51					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ctccataacggaactcgcaat	0.398000													83	183					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43679421	43679421	+	Missense_Mutation	SNP	G	G	A	rs150587441	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43679421G>A	ENST00000404580.1	-	4	998	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C	PSG5_ENST00000599812.1_Missense_Mutation_p.R397C|PSG5_ENST00000407356.1_Missense_Mutation_p.R304C|PSG5_ENST00000342951.6_Missense_Mutation_p.R304C|PSG5_ENST00000366175.3_Missense_Mutation_p.R304C|PSG5_ENST00000407568.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	304	Ig-like C2-type 2.				female pregnancy	extracellular region		p.R304C(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GCTGAGTTACGAACAGAGCAA	0.443000													106	262					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167129313	167129313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167129313G>A	ENST00000375387.4	-	17	3290	c.2950C>T	c.(2950-2952)Cct>Tct	p.P984S	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Missense_Mutation_p.P983S|SCN9A_ENST00000409672.1_Missense_Mutation_p.P972S|SCN9A_ENST00000303354.6_Missense_Mutation_p.P984S			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	983						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTTGCATCAGGGTCTTCTTCA	0.373000													13	30					0	0	1	0	0
ESM1	11082	broad.mit.edu	37	5	54281334	54281334	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54281334G>A	ENST00000381405.4	-	1	157	c.12C>T	c.(10-12)gtC>gtT	p.V4V	ESM1_ENST00000598310.1_Intron|ESM1_ENST00000381403.4_Silent_p.V4V	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	4					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			TCAGCAGCAAGACGCTCTTCA	0.597000													10	59					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144359624	144359624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:144359624C>T	ENST00000262995.4	+	4	1493	c.1066C>T	c.(1066-1068)Cct>Tct	p.P356S	GAB1_ENST00000262994.4_Missense_Mutation_p.P356S|GAB1_ENST00000505913.1_Missense_Mutation_p.P253S	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	356					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					TGACCGATCTCCTGTGGAAAC	0.498000													27	88					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45322051	45322051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45322051C>T	ENST00000391955.1	+	10	1292	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F	BCAM_ENST00000270233.6_Silent_p.F416F			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	416	Ig-like C2-type 2.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CTATCACCTTCGATTCCAATG	0.627000													54	96					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57379309	57379309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57379309G>A	ENST00000403558.1	+	6	1644	c.1278G>A	c.(1276-1278)atG>atA	p.M426I	SERPING1_ENST00000278407.4_Missense_Mutation_p.M383I|SERPING1_ENST00000378324.2_Missense_Mutation_p.M331I|SERPING1_ENST00000340687.6_Missense_Mutation_p.M346I|SERPING1_ENST00000378323.4_Missense_Mutation_p.M388I	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	383					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						AGGCCATCATGGAGAAACTGG	0.498000													40	119					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70319451	70319451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70319451C>T	ENST00000338508.4	-	33	5075	c.5076G>A	c.(5074-5076)caG>caA	p.Q1692Q	SHANK2_ENST00000423696.2_Silent_p.Q1312Q|SHANK2_ENST00000409161.1_Silent_p.Q1095Q|SHANK2_ENST00000449833.2_Silent_p.Q1096Q			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1312					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGGGCCGGCTCTGCAGGGTGA	0.617000													7	35					0	0	1	0	0
FAM86FP	653113	broad.mit.edu	37	12	8386984	8386984	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8386984G>A	ENST00000427893.2	-	0	782																											GCAGGACCCCGACCAGCGACA	0.587000													12	65					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48802271	48802271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48802271G>A	ENST00000316623.5	-	14	2139	c.1684C>T	c.(1684-1686)Cat>Tat	p.H562Y		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	562	EGF-like 8; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CGTGTAACATGAAAGCCCGCA	0.408000													25	66					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167517611	167517611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167517611G>A	ENST00000519204.1	+	7	1303	c.1185G>A	c.(1183-1185)gaG>gaA	p.E395E	TENM2_ENST00000545108.1_Silent_p.E516E|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000518659.1_Silent_p.E516E|TENM2_ENST00000520394.1_Silent_p.E284E|TENM2_ENST00000403607.2_Silent_p.E349E					teneurin transmembrane protein 2																		ACGGGAAGGAGAAGTGGAGTG	0.537000													23	86					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671462	39671462	+	Silent	SNP	G	G	A	rs145343844		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39671462G>A	ENST00000398930.1	+	4	633	c.279G>A	c.(277-279)ggG>ggA	p.G93G	KCNJ15_ENST00000398938.2_Silent_p.G93G|KCNJ15_ENST00000398932.1_Silent_p.G93G|KCNJ15_ENST00000398934.1_Silent_p.G93G|KCNJ15_ENST00000328656.3_Silent_p.G93G			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	93					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						TTATTCATGGGGACTTAGAAC	0.478000													49	106					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138414689	138414689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:138414689G>A	ENST00000409968.1	+	24	4512	c.4334G>A	c.(4333-4335)cGa>cAa	p.R1445Q	THSD7B_ENST00000272643.3_Missense_Mutation_p.R1448Q|THSD7B_ENST00000413152.2_Missense_Mutation_p.R1417Q|THSD7B_ENST00000543459.1_Missense_Mutation_p.E280K					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATAACGAACGAACTGTATGG	0.413000													16	48					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23083503	23083503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23083503G>A	ENST00000219689.7	-	15	2350	c.2351C>T	c.(2350-2352)tCc>tTc	p.S784F	USP31_ENST00000567975.1_Missense_Mutation_p.S77F	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	784	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		TTCACACAGGGAAGAACTTGT	0.622000													17	52					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2150448	2150448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2150448G>A	ENST00000262304.4	-	27	9725	c.9517C>T	c.(9517-9519)Ccg>Tcg	p.P3173S	PKD1_ENST00000423118.1_Missense_Mutation_p.P3173S	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	3173	PLAT.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AGGCTGTGCGGGGTGGCGATC	0.652000													7	72					0	0	1	0	0
GCM2	9247	broad.mit.edu	37	6	10876690	10876690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:10876690C>T	ENST00000379491.4	-	3	591	c.444G>A	c.(442-444)gcG>gcA	p.A148A	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	148					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				GAAAAAAGATCGCGTTGCCAT	0.498000													14	47					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18896895	18896895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18896895C>T	ENST00000542601.2	-	12	1659	c.1270G>A	c.(1270-1272)Gag>Aag	p.E424K	COMP_ENST00000425807.1_Missense_Mutation_p.E404K|COMP_ENST00000222271.2_Missense_Mutation_p.E457K			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	457					anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding	p.E457K(1)		breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						TCTGAGTCCTCCTGGGCACTG	0.602000													17	29					0	0	1	0	0
MDH2	4191	broad.mit.edu	37	7	75689783	75689783	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:75689783C>T	ENST00000315758.5	+	5	616	c.522C>T	c.(520-522)atC>atT	p.I174I	MDH2_ENST00000443006.1_Silent_p.I67I|MDH2_ENST00000432020.2_Intron	NM_005918.2	NP_005909.2	P40926	MDHM_HUMAN	malate dehydrogenase 2, NAD (mitochondrial)	174					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(2)	14					NADH(DB00157)	CCCTGGACATCGTCAGAGCCA	0.522000													23	41					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2924928	2924928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:2924928G>A	ENST00000397461.1	+	8	1136	c.752G>A	c.(751-753)gGa>gAa	p.G251E	CNTN4_ENST00000418658.1_Missense_Mutation_p.G251E|CNTN4_ENST00000427331.1_Missense_Mutation_p.G251E|CNTN4_ENST00000358480.3_Missense_Mutation_p.G32E	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	251	Ig-like C2-type 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TTTGCTTTAGGAAAGTAAGTT	0.468000													6	33					0	0	1	0	0
PAPSS1	9061	broad.mit.edu	37	4	108608330	108608330	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:108608330G>A	ENST00000265174.4	-	4	687	c.415C>T	c.(415-417)Cgc>Tgc	p.R139C	PAPSS1_ENST00000511304.1_5'UTR	NM_005443.4	NP_005434.4	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 1	139					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|ovary(1)	16		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		GCATTGTTGCGATCCttaaaa	0.328000													26	48					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53242382	53242382	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53242382C>T	ENST00000304620.4	-	1	396	c.333G>A	c.(331-333)gaG>gaA	p.E111E		NM_173352.2	NP_775487.2	Q8N1N4	K2C78_HUMAN	keratin 78	111	Coil 1A.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						TCTCCTGGGTCTCCTGCGTCC	0.567000													9	67					0	0	1	0	0
CAMK2D	817	broad.mit.edu	37	4	114438809	114438809	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114438809G>A	ENST00000454265.2	-	9	1464	c.606C>T	c.(604-606)gtC>gtT	p.V202V	CAMK2D_ENST00000394522.3_Silent_p.V202V|CAMK2D_ENST00000515496.1_Silent_p.V202V|CAMK2D_ENST00000514328.1_Silent_p.V202V|CAMK2D_ENST00000429180.1_Silent_p.V202V|CAMK2D_ENST00000342666.5_Silent_p.V202V|CAMK2D_ENST00000418639.2_Silent_p.V202V|CAMK2D_ENST00000508738.1_Silent_p.V202V|CAMK2D_ENST00000379773.2_Silent_p.V202V|CAMK2D_ENST00000505990.1_Silent_p.V202V|CAMK2D_ENST00000511664.1_Silent_p.V202V|CAMK2D_ENST00000296402.5_Silent_p.V202V|CAMK2D_ENST00000394524.3_Silent_p.V202V|CAMK2D_ENST00000394526.2_Silent_p.V202V			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	202	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TATAGAGAATGACACCTGGAG	0.373000													13	96					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109513544	109513544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:109513544C>T	ENST00000409271.1	-	12	1705	c.1262G>A	c.(1261-1263)gGg>gAg	p.G421E	EDAR_ENST00000376651.1_Missense_Mutation_p.G421E|EDAR_ENST00000258443.2_Missense_Mutation_p.G389E			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	389	Death.				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TGTCATGCCCCCAATCTCATC	0.562000													16	38					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101776985	101776985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:101776985C>T	ENST00000251127.6	-	18	2247	c.2166G>A	c.(2164-2166)aaG>aaA	p.K722K		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	722						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGCGGTCTCCTTTTCCAGAA	0.323000													57	109					0	0	1	0	0
TMEM154	201799	broad.mit.edu	37	4	153564299	153564299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:153564299G>A	ENST00000304385.3	-	5	650	c.419C>T	c.(418-420)tCt>tTt	p.S140F		NM_152680.2	NP_689893.1	Q6P9G4	TM154_HUMAN	transmembrane protein 154	140						integral to membrane				kidney(2)|large_intestine(1)	3	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TTCCATAACAGAGGGTGTATC	0.338000													19	81					0	0	1	0	0
OBP2A	29991	broad.mit.edu	37	9	138440520	138440520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138440520C>T	ENST00000342114.4	+	4	328	c.286C>T	c.(286-288)Ccc>Tcc	p.P96S	OBP2A_ENST00000340780.3_Silent_p.S140S|OBP2A_ENST00000539850.1_Intron|OBP2A_ENST00000371776.1_Intron			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	123					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		TGCCGCTGTCCCCACCTTGGC	0.597000													4	27					0	0	1	0	0
IGHV6-1	28385	broad.mit.edu	37	14	106405642	106405642	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106405642G>A	ENST00000390593.2	-	0	383																											CGTGTCCTCGGGAGTCACAGA	0.502000													72	150					0	0	1	0	0
GJB4	127534	broad.mit.edu	37	1	35227279	35227279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35227279G>A	ENST00000339480.1	+	2	794	c.424G>A	c.(424-426)Gat>Aat	p.D142N	RP1-34M23.5_ENST00000542839.1_RNA	NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	142					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GGCCGCCGTGGATGCTGGCTT	0.612000													18	54					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323175	61323175	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61323175C>T	ENST00000283752.5	-	8	1032	c.889G>A	c.(889-891)Gac>Aac	p.D297N	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.D245N	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	297					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity	p.D297N(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						CTCAACGTGTCCTTGAGGTCA	0.488000													25	119					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209823449	209823449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209823449G>A	ENST00000391911.1	-	2	432	c.43C>T	c.(43-45)Ctg>Ttg	p.L15L	LAMB3_ENST00000356082.4_Silent_p.L15L|LAMB3_ENST00000367030.3_Silent_p.L15L	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	15					cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TGGGCATGCAGGAGGCCAGGC	0.577000													9	15					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228547865	228547865	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228547865G>A	ENST00000284548.11	+	81	19346	c.19272G>A	c.(19270-19272)atG>atA	p.M6424I	OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000570156.2_Intron|OBSCN_ENST00000366709.4_Missense_Mutation_p.M3543I			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0	Ig-like 54.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGGCACCATGGAGGAGGCGG	0.637000													13	13					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050067	42050067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42050067C>T	ENST00000372584.1	-	3	1416	c.402G>A	c.(400-402)gtG>gtA	p.V134V	HIVEP3_ENST00000429157.2_Silent_p.V134V|HIVEP3_ENST00000372583.1_Silent_p.V134V|HIVEP3_ENST00000247584.5_Silent_p.V134V	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	134				FV -> LL (in Ref. 1; AAK01082).	positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCCCAGGGGCCACGAAGGAGC	0.612000													52	107					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74151734	74151734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74151734G>A	ENST00000269391.6	-	15	1739	c.1607C>T	c.(1606-1608)tCt>tTt	p.S536F	RNF157_ENST00000319945.6_Missense_Mutation_p.S536F	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	536	Ser-rich.						zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			GTAGGAGCCAGACATGGAGGA	0.617000													8	29					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47514238	47514238	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47514238G>A	ENST00000371901.3	+	10	1459	c.1207_splice	c.e10-1	p.G403_splice	CYP4X1_ENST00000538609.1_Splice_Site_p.G402_splice	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	403						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						CTTTCTTAGGGATCACCGTGG	0.428000													73	267					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152515623	152515623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152515623G>A	ENST00000427231.2	-	47	6233	c.6031C>T	c.(6031-6033)Ccc>Tcc	p.P2011S	NEB_ENST00000604864.1_Missense_Mutation_p.P2011S|NEB_ENST00000603639.1_Missense_Mutation_p.P2011S|NEB_ENST00000172853.10_Missense_Mutation_p.P2011S|NEB_ENST00000397345.3_Missense_Mutation_p.P2011S|NEB_ENST00000409198.1_Missense_Mutation_p.P2011S	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2011					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATAATCTGGGGGATATCAGGC	0.378000													73	168					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10280488	10280488	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10280488C>T	ENST00000256458.4	+	12	1620	c.1530C>T	c.(1528-1530)ctC>ctT	p.L510L		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	510					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						AGACGTTGCTCCCTTGGAGTG	0.557000													33	133					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958002	121958002	+	Missense_Mutation	SNP	G	G	A	rs143734180	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121958002G>A	ENST00000379692.4	-	4	1650	c.1124C>T	c.(1123-1125)aCc>aTc	p.T375I		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	375										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						AATAAAGAAGGTGACTTTTTG	0.418000													44	119					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167176	140167176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140167176C>T	ENST00000504120.2	+	1	1301	c.1301C>T	c.(1300-1302)tCg>tTg	p.S434L	PCDHA1_ENST00000378133.3_Missense_Mutation_p.S434L|PCDHA1_ENST00000394633.3_Missense_Mutation_p.S434L	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTCGCCTTCGCTGTGGGCC	0.627000													48	151					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111474509	111474509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111474509C>T	ENST00000265162.5	+	18	2882	c.2540C>T	c.(2539-2541)aCt>aTt	p.T847I		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	847					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CTTATTAAAACTCAGGATGTG	0.368000													29	132					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219903697	219903697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219903697G>A	ENST00000341552.5	-	3	157	c.74C>T	c.(73-75)tCt>tTt	p.S25F	CCDC108_ENST00000295729.2_Intron|CCDC108_ENST00000324264.6_5'UTR|CCDC108_ENST00000453220.1_Missense_Mutation_p.S25F|CCDC108_ENST00000410037.1_Intron|CCDC108_ENST00000409865.3_Intron|CCDC108_ENST00000441968.1_Missense_Mutation_p.S25F	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	25						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGAAAGAAGAGGCAAATGA	0.408000													35	77					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44595299	44595299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44595299C>T	ENST00000372299.3	+	2	414	c.356C>T	c.(355-357)cCc>cTc	p.P119L	KLF17_ENST00000476802.1_Intron	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	119					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					AGAATGTCTCCCCCTCAGCAA	0.552000													36	129					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149879693	149879693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149879693G>A	ENST00000369146.3	-	9	1935	c.1445C>T	c.(1444-1446)tCc>tTc	p.S482F	SV2A_ENST00000369145.1_Missense_Mutation_p.S482F	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	482					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TTTGGTGCGGGATGCGTAGTC	0.527000													47	155					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756611	15756611	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15756611C>T	ENST00000221307.7	+	3	329	c.281C>T	c.(280-282)cCc>cTc	p.P94L	CYP4F3_ENST00000586182.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000591058.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	94					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						TGGGTGGGGCCCTGGCACGCA	0.567000													27	58					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52714601	52714601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52714601C>T	ENST00000322088.6	+	4	417	c.359C>T	c.(358-360)tCg>tTg	p.S120L	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.S65L|PPP2R1A_ENST00000473455.2_3'UTR|PPP2R1A_ENST00000462990.1_5'UTR	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	120	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.S120L(1)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CACGAGCACTCGCCCTCTGAC	0.662000			Mis		clear cell ovarian carcinoma								10	89					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15303785	15303785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:15303785C>T	ENST00000383791.3	-	5	727	c.507G>A	c.(505-507)gcG>gcA	p.A169A	SH3BP5_ENST00000253688.5_Silent_p.A12A|SH3BP5-AS1_ENST00000420195.1_RNA|SH3BP5_ENST00000408919.3_Silent_p.A12A|SH3BP5_ENST00000426925.1_Silent_p.A12A	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	169					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						TGGTCTGCTCCGCCTCCATGA	0.498000													18	57					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97484999	97484999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:97484999C>T	ENST00000376705.2	+	2	987	c.963C>T	c.(961-963)ggC>ggT	p.G321G		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	321						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					GCCTGGTGGGCTGCTATAACT	0.512000													29	71					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25264767	25264767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:25264767C>T	ENST00000216962.4	+	14	1758	c.1648C>T	c.(1648-1650)Ctg>Ttg	p.L550L		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	550					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	CTCGGCCTTCCTGGAGAAGGA	0.552000													36	78					0	0	1	0	0
ZFP69B	65243	broad.mit.edu	37	1	40922631	40922631	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40922631C>T	ENST00000484445.1	+	3	508	c.142C>T	c.(142-144)Caa>Taa	p.Q48*	ZFP69B_ENST00000361584.3_5'UTR|ZFP69B_ENST00000411995.2_Silent_p.F76F					ZFP69 zinc finger protein B																		TGTTAACCTTCAAGGACGTAT	0.488000													12	23					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95676990	95676990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95676990C>T	ENST00000433389.2	+	7	900	c.710C>T	c.(709-711)tCa>tTa	p.S237L	ESRP1_ENST00000358397.5_Missense_Mutation_p.S237L|ESRP1_ENST00000454170.2_Missense_Mutation_p.S237L|ESRP1_ENST00000423620.2_Missense_Mutation_p.S237L	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	237	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding	p.S237*(2)	ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						TGGCAGTCTTCAGATCAAGAT	0.373000													19	65					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13563773	13563773	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13563773G>A	ENST00000360228.5	-	3	455	c.456C>T	c.(454-456)atC>atT	p.I152I	CACNA1A_ENST00000573710.2_Silent_p.I152I	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	152					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CAAGGGCAATGATTTTAATTC	0.498000													57	139					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91292892	91292892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91292892C>T	ENST00000355112.3	+	3	512	c.394C>T	c.(394-396)Cgg>Tgg	p.R132W	BLM_ENST00000560509.1_Missense_Mutation_p.R132W	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	132					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			AAAGAAATCCCGGGATACTGC	0.388000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				13	90					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39019006	39019006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39019006C>T	ENST00000355481.4	+	73	11001	c.10870C>T	c.(10870-10872)Cgg>Tgg	p.R3624W	AC067969.1_ENST00000597015.1_RNA|RYR1_ENST00000359596.3_Missense_Mutation_p.R3629W|RYR1_ENST00000360985.3_Missense_Mutation_p.R3629W	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3629					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.R3629W(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CAAACAGCGCCGGCGGGCAGT	0.612000													21	75					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160788098	160788098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160788098G>A	ENST00000263285.5	+	6	1463	c.1433G>A	c.(1432-1434)cGa>cAa	p.R478Q	LY9_ENST00000368035.1_Missense_Mutation_p.R130Q|LY9_ENST00000368041.2_Missense_Mutation_p.R348Q|LY9_ENST00000341032.4_Missense_Mutation_p.R388Q|LY9_ENST00000368040.1_Missense_Mutation_p.R130Q	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	478					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATTTGGAAGCGAAAAGGACGG	0.522000													9	104					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36351438	36351438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36351438C>T	ENST00000360202.5	+	7	995	c.797C>T	c.(796-798)tCt>tTt	p.S266F	NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000586102.2_Missense_Mutation_p.S246F|KIRREL2_ENST00000347900.6_Missense_Mutation_p.S216F|KIRREL2_ENST00000262625.7_Missense_Mutation_p.S266F|KIRREL2_ENST00000592409.1_Missense_Mutation_p.S266F	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	266	Ig-like C2-type 3.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAAGGGGGCTCTCCGGTGCTC	0.642000													20	69					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52371064	52371064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52371064G>A	ENST00000296585.5	+	23	2898	c.2755G>A	c.(2755-2757)Gaa>Aaa	p.E919K		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	919					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AAGCCAAGAAGAAAACAAGGC	0.348000													21	39					0	0	1	0	0
IL2RB	3560	broad.mit.edu	37	22	37524322	37524322	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37524322C>T	ENST00000216223.5	-	10	1668	c.1470G>A	c.(1468-1470)gaG>gaA	p.E490E		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	490					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GCAGCACCAGCTCAGGGGGTG	0.667000													12	37					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5283061	5283061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5283061C>T	ENST00000546004.1	-	3	1026	c.780G>A	c.(778-780)acG>acA	p.T260T	PROKR2_ENST00000217270.3_Silent_p.T260T			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	260						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GAATCTGCTCCGTCTGGAACC	0.607000										HNSCC(71;0.22)			22	55					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63149660	63149660	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63149660G>A	ENST00000279178.3	+	6	1233	c.984G>A	c.(982-984)ctG>ctA	p.L328L	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	328					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						AAAAAGAACTGGAGGCAGCAC	0.408000													64	131					0	0	1	0	0
LRRC52	440699	broad.mit.edu	37	1	165533037	165533037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165533037C>T	ENST00000294818.1	+	2	1208	c.918C>T	c.(916-918)gtC>gtT	p.V306V	RP11-280O1.2_ENST00000421273.1_RNA|RP11-280O1.2_ENST00000416424.1_RNA|RP11-280O1.2_ENST00000438275.1_RNA	NM_001005214.3	NP_001005214.2	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52	306						integral to membrane				NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)	18	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					CGAGCTCGGTCCAGGAGTTCC	0.567000													37	93					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10071223	10071223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10071223C>T	ENST00000264828.3	-	67	5187	c.5102G>A	c.(5101-5103)gGa>gAa	p.G1701E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1701	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CTTCGTCTGTCCTTTCCGGAG	0.577000													40	103					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611474	179611474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179611474C>T	ENST00000360870.5	-	46	15875	c.15653G>A	c.(15652-15654)cGa>cAa	p.R5218Q	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8737	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R5218Q(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATTTATTTCGATACCATTT	0.373000													42	103					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90086735	90086735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90086735C>T	ENST00000405460.2	+	70	14185	c.14089C>T	c.(14089-14091)Ctt>Ttt	p.L4697F	GPR98_ENST00000425867.2_Missense_Mutation_p.L358F	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4697	Calx-beta 32.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGAAGACTTTCTTTCCACCAG	0.348000													40	85					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701558	143701558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143701558C>T	ENST00000408922.2	+	1	537	c.469C>T	c.(469-471)Ctg>Ttg	p.L157L		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TGGCATCTCCCTGGCGAAGAT	0.537000													27	45					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7950069	7950069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7950069G>A	ENST00000309838.2	-	1	140	c.141C>T	c.(139-141)gtC>gtT	p.V47V		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGGAGACGATGACTATAATAA	0.463000													41	98					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92731606	92731606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92731606C>T	ENST00000379958.2	-	3	4074	c.3805G>A	c.(3805-3807)Gat>Aat	p.D1269N		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1269						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TCAAAAAAATCAAAGGACTTT	0.313000													21	65					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43774687	43774687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43774687C>T	ENST00000372476.3	+	8	1152	c.1073C>T	c.(1072-1074)tCa>tTa	p.S358L	TIE1_ENST00000433781.2_Missense_Mutation_p.S3L|TIE1_ENST00000441333.2_Intron	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	358					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AACATGGCCTCAGAACTGGAG	0.602000													15	70					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10576035	10576035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10576035G>A	ENST00000396560.2	+	12	2205	c.1978G>A	c.(1978-1980)Gat>Aat	p.D660N	ATF7IP2_ENST00000396559.1_3'UTR|ATF7IP2_ENST00000543967.1_Missense_Mutation_p.D204N|ATF7IP2_ENST00000356427.2_Missense_Mutation_p.D660N|ATF7IP2_ENST00000324570.5_3'UTR	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	660	Fibronectin type-III.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						CCAATCAAAAGATATTTTTGG	0.328000													16	93					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74622633	74622633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74622633G>A	ENST00000321288.5	+	14	2003	c.2003G>A	c.(2002-2004)aGc>aAc	p.S668N	CCDC33_ENST00000398814.3_Missense_Mutation_p.S465N|CCDC33_ENST00000268082.4_Missense_Mutation_p.S58N|CCDC33_ENST00000558821.1_Missense_Mutation_p.S58N			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	668							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						ATACTGAGGAGCCGCCTGGCC	0.627000													4	25					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333073	70333073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70333073C>T	ENST00000338508.4	-	32	3327	c.3328G>A	c.(3328-3330)Gat>Aat	p.D1110N	SHANK2_ENST00000423696.2_Missense_Mutation_p.D730N|SHANK2_ENST00000409161.1_Missense_Mutation_p.D513N|SHANK2_ENST00000449833.2_Missense_Mutation_p.D514N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	730					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACATCCTCATCCCCCAGGTCT	0.697000													15	37					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144062345	144062345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:144062345G>A	ENST00000056217.5	+	2	2757	c.2583G>A	c.(2581-2583)agG>agA	p.R861R		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	861					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					CCAGGGGGAGGAGCAGGAGCA	0.597000													15	134					0	0	1	0	0
WIPF1	7456	broad.mit.edu	37	2	175436545	175436545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:175436545C>T	ENST00000392547.2	-	5	1087	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	WIPF1_ENST00000359761.3_Missense_Mutation_p.E330K|WIPF1_ENST00000409891.1_Missense_Mutation_p.E330K|WIPF1_ENST00000272746.5_Missense_Mutation_p.E330K|AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000392546.2_Missense_Mutation_p.E330K|AC018890.6_ENST00000412835.1_RNA|WIPF1_ENST00000409415.3_Missense_Mutation_p.E330K	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	330	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						CTTGGGGTTTCGTCATTGCCG	0.677000													5	58					0	0	1	0	0
RMDN2	151393	broad.mit.edu	37	2	38178625	38178625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:38178625C>T	ENST00000407257.1	+	2	414	c.267C>T	c.(265-267)tcC>tcT	p.S89S	RMDN2-AS1_ENST00000414365.2_RNA|RMDN2_ENST00000406384.1_Intron|RMDN2_ENST00000402091.3_Silent_p.S89S|RMDN2_ENST00000354545.2_Intron|RMDN2_ENST00000234195.3_Silent_p.S89S|RMDN2_ENST00000417700.2_Intron					regulator of microtubule dynamics 2																		GAAATGCTTCCCCTTACTGGC	0.363000													43	106					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130286970	130286970	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130286970G>A	ENST00000358511.6	+	5	1954	c.1923G>A	c.(1921-1923)atG>atA	p.M641I	COL6A6_ENST00000453409.2_Missense_Mutation_p.M641I	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	641	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCAGCAAAATGAAAACATTTA	0.413000													47	79					0	0	1	0	0
SLC17A7	57030	broad.mit.edu	37	19	49939943	49939943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49939943G>A	ENST00000221485.3	-	2	349	c.178C>T	c.(178-180)Cct>Tct	p.P60S	SLC17A7_ENST00000543531.1_Missense_Mutation_p.P48S|SLC17A7_ENST00000600601.1_5'UTR	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	60					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		TAGCGGCGAGGGAGGCCGAAG	0.647000													42	101					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51852422	51852422	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51852422G>A	ENST00000453097.2	+	7	1060	c.843G>A	c.(841-843)gtG>gtA	p.V281V	SLC4A8_ENST00000394856.1_Silent_p.V228V|SLC4A8_ENST00000358657.3_Silent_p.V308V|SLC4A8_ENST00000514353.3_Silent_p.V228V|SLC4A8_ENST00000535225.2_Silent_p.V228V	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	281					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		ATAGTCCTGTGGATTTAAGCA	0.408000													15	81					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7580655	7580655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7580655G>A	ENST00000379802.3	+	23	4573	c.4232G>A	c.(4231-4233)aGg>aAg	p.R1411K	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1411	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAAATAAAGAGGCTGAAGAAC	0.498000													32	52					0	0	1	0	0
LAPTM4B	55353	broad.mit.edu	37	8	98837319	98837319	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:98837319C>T	ENST00000445593.2	+	6	1494	c.814C>T	c.(814-816)Cga>Tga	p.R272*	LAPTM4B_ENST00000521545.2_Nonsense_Mutation_p.R181*	NM_018407.4	NP_060877.3	Q86VI4	LAP4B_HUMAN	lysosomal protein transmembrane 4 beta	325					transport	endomembrane system|integral to membrane	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	10	Breast(36;1.59e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.149)			GAACTGCTACCGATACATCAA	0.403000													9	88					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118629336	118629336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:118629336C>T	ENST00000336338.5	-	12	1634	c.1569G>A	c.(1567-1569)ctG>ctA	p.L523L		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	523						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CATGATAGTTCAGTAGGAGGG	0.378000													45	98					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139890104	139890104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139890104C>T	ENST00000303045.6	-	3	993	c.547G>A	c.(547-549)Gag>Aag	p.E183K	COL22A1_ENST00000435777.1_Missense_Mutation_p.E183K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	183	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCCAGCTCCTCCTTGAGTGCC	0.692000										HNSCC(7;0.00092)			11	24					0	0	1	0	0
PFKFB2	5208	broad.mit.edu	37	1	207228079	207228079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207228079C>T	ENST00000367080.3	+	2	141	c.17C>T	c.(16-18)tCc>tTc	p.S6F	PFKFB2_ENST00000367079.2_Missense_Mutation_p.S6F|PFKFB2_ENST00000411990.2_5'UTR|PFKFB2_ENST00000545806.1_5'UTR	NM_006212.2	NP_006203.2	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	6	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	20	Prostate(682;0.19)					GGGGCATCTTCCTCAGAACAG	0.423000													13	20					0	0	1	0	0
TMEM176A	55365	broad.mit.edu	37	7	150498668	150498668	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150498668C>T	ENST00000484928.1	+	2	611	c.30C>T	c.(28-30)gcC>gcT	p.A10A	TMEM176A_ENST00000004103.3_Silent_p.A10A|TMEM176A_ENST00000461345.1_Intron			Q96HP8	T176A_HUMAN	transmembrane protein 176A	10						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ATGAGATGGCCCCGGAGGCCC	0.607000													21	47					0	0	1	0	0
GPR155	151556	broad.mit.edu	37	2	175304647	175304647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:175304647C>T	ENST00000392552.2	-	15	2529	c.2291G>A	c.(2290-2292)cGa>cAa	p.R764Q	GPR155_ENST00000392551.2_Missense_Mutation_p.R764Q|GPR155_ENST00000295500.4_Missense_Mutation_p.R764Q|GPR155_ENST00000459996.1_5'UTR	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155	764	DEP.				intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						GACAATGTTTCGGATACAGAG	0.333000													28	88					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22078966	22078966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22078966G>A	ENST00000454243.2	-	5	1467	c.893C>T	c.(892-894)aCc>aTc	p.T298I	PHYHIP_ENST00000321613.3_Missense_Mutation_p.T298I	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	298										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		CTCCCCCAGGGTGCCCAGGGA	0.627000													29	100					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142634	48142634	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48142634G>A	ENST00000405493.2	-	11	1205	c.996C>T	c.(994-996)ggC>ggT	p.G332G	RAPGEF3_ENST00000548919.1_Silent_p.G332G|RAPGEF3_ENST00000449771.2_Silent_p.G374G|RAPGEF3_ENST00000395358.3_Silent_p.G374G|RAPGEF3_ENST00000549151.1_Silent_p.G332G|RAPGEF3_ENST00000389212.3_Silent_p.G374G|RAPGEF3_ENST00000171000.4_Silent_p.G332G	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	332					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GTCGGGAAGGGCCGGCGCCCT	0.597000													41	110					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45410266	45410266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45410266G>A	ENST00000332700.6	-	4	994	c.823C>T	c.(823-825)Cca>Tca	p.P275S		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	275						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GAAGGACATGGAGAAGGGAAA	0.493000													46	104					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079198	57079198	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57079198A>G	ENST00000316981.3	-	5	1586	c.1107T>C	c.(1105-1107)tcT>tcC	p.S369S	PLAG1_ENST00000429357.2_Silent_p.S369S|PLAG1_ENST00000423799.2_Silent_p.S287S	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	369	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			CTTGGGATGAAGAGGGCACGC	0.453000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								47	119					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55439064	55439064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55439064G>A	ENST00000588756.1	-	12	3376	c.2890C>T	c.(2890-2892)Ctg>Ttg	p.L964L	NLRP7_ENST00000328092.5_Silent_p.L936L|NLRP7_ENST00000340844.2_Intron|NLRP7_ENST00000448121.2_Silent_p.L936L|NLRP7_ENST00000590030.1_Intron|NLRP7_ENST00000592784.1_Silent_p.L964L|NLRP7_ENST00000446217.1_Silent_p.L992L			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	0							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CCCAGGTCCAGAGTTTCAAGC	0.463000													22	171					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179648970	179648970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179648970C>T	ENST00000589042.1	-	16	2826	c.2602G>A	c.(2602-2604)Gag>Aag	p.E868K	TTN_ENST00000342992.6_Missense_Mutation_p.E868K|TTN_ENST00000360870.5_Missense_Mutation_p.E868K|TTN_ENST00000591111.1_Missense_Mutation_p.E868K|TTN_ENST00000342175.6_Missense_Mutation_p.E822K|TTN_ENST00000359218.5_Missense_Mutation_p.E822K|TTN_ENST00000460472.2_Missense_Mutation_p.E822K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	868							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCTAGTCTCACTGGGCTTC	0.502000													30	59					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89259263	89259263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:89259263G>A	ENST00000336596.2	+	3	632	c.407G>A	c.(406-408)cGa>cAa	p.R136Q	EPHA3_ENST00000494014.1_Missense_Mutation_p.R136Q|EPHA3_ENST00000452448.2_Missense_Mutation_p.R136Q	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	136						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTGAAATTTCGAGAGCATCAG	0.418000										TSP Lung(6;0.00050)			33	168					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96745889	96745889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96745889G>A	ENST00000260682.6	+	8	1261	c.1249G>A	c.(1249-1251)Ggc>Agc	p.G417S		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	417			G -> D.		exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GGATGAAGGTGGCAATTTTAA	0.363000													54	109					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200143213	200143213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200143213C>T	ENST00000367362.3	+	8	1747	c.1501C>T	c.(1501-1503)Ctt>Ttt	p.L501F	NR5A2_ENST00000236914.3_Missense_Mutation_p.L455F|NR5A2_ENST00000544748.1_Missense_Mutation_p.L429F	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	501					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					ACAGCTACTTCTTCGACTACC	0.498000													16	30					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33696189	33696189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33696189C>T	ENST00000253193.7	+	5	715	c.513C>T	c.(511-513)ttC>ttT	p.F171F	LRP3_ENST00000592484.1_3'UTR	NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	171	LDL-receptor class A 1.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					CAGATGAGTTCCGCTGTGACA	0.662000													3	10					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099318	168099318	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168099318C>T	ENST00000409195.1	+	9	1505	c.1416C>T	c.(1414-1416)tcC>tcT	p.S472S	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Silent_p.S472S|XIRP2_ENST00000409273.1_Silent_p.S250S|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	297					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTTCCCAGTCCCCTGAACTGC	0.413000													43	75					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20045433	20045433	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20045433A>G	ENST00000343769.5	+	4	1697	c.1669A>G	c.(1669-1671)Ata>Gta	p.I557V	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	557						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						TACACATAAGATACTTCATAC	0.358000													23	46					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615651	179615651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179615651C>T	ENST00000360870.5	-	46	11698	c.11476G>A	c.(11476-11478)Gaa>Aaa	p.E3826K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9660							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTAGAATTTCACCATATAAA	0.348000													53	137					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11584065	11584065	+	Missense_Mutation	SNP	G	G	A	rs61744927		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11584065G>A	ENST00000294484.6	+	11	2567	c.2429G>A	c.(2428-2430)cGa>cAa	p.R810Q	PTCHD2_ENST00000389575.3_Missense_Mutation_p.R810Q	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	810					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AAGAAGAGGCGAGGCTCAGGG	0.652000													6	50					0	0	1	0	0
NACAP1	83955	broad.mit.edu	37	8	102381246	102381246	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:102381246G>A	ENST00000419462.1	+	0	658					NR_002182.1																						GTCAGTACCAGAGCTTGAAGA	0.517000													7	88					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14157367	14157367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14157367G>A	ENST00000263379.2	+	8	1203	c.1078G>A	c.(1078-1080)Gac>Aac	p.D360N		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	360	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						TCGAGATGGGGACCCCCTGGA	0.647000													31	100					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34528852	34528852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34528852G>A	ENST00000374012.3	+	17	2908	c.2779G>A	c.(2779-2781)Ggt>Agt	p.G927S	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	927					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GCTGGACAGAGGTGGAGAGGG	0.532000													41	89					0	0	1	0	0
UPK3B	80761	broad.mit.edu	37	7	76141016	76141016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76141016C>T	ENST00000419923.2	+	2	668	c.443C>T	c.(442-444)cCg>cTg	p.P148L	UPK3B_ENST00000334348.3_Missense_Mutation_p.P93L|UPK3B_ENST00000448265.3_Missense_Mutation_p.P148L|UPK3B_ENST00000257632.5_Missense_Mutation_p.P148L|UPK3B_ENST00000443097.2_Missense_Mutation_p.P93L|UPK3B_ENST00000394849.1_Missense_Mutation_p.P93L			Q9BT76	UPK3B_HUMAN	uroplakin 3B	148					negative regulation of gene expression	integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(1)|skin(2)	8		Myeloproliferative disorder(862;0.204)				GCTGACATTCCGGCCTCCCCA	0.647000													4	20					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240286576	240286576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240286576C>T	ENST00000319653.9	+	2	1943	c.1713C>T	c.(1711-1713)ctC>ctT	p.L571L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	571					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGGGTCTTCTCCTTCCTTTTA	0.507000													30	85					0	0	1	0	0
CARD9	64170	broad.mit.edu	37	9	139264822	139264822	+	Missense_Mutation	SNP	C	C	T	rs143263677		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139264822C>T	ENST00000371732.5	-	6	1040	c.875G>A	c.(874-876)cGg>cAg	p.R292Q	CARD9_ENST00000315908.7_Missense_Mutation_p.R292Q|CARD9_ENST00000371734.3_Missense_Mutation_p.R292Q	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	292					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		CTGGTGGTCCCGCAGCGCCTG	0.682000													8	4					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145584116	145584116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145584116C>T	ENST00000532887.1	+	3	1547	c.964C>T	c.(964-966)Ccc>Tcc	p.P322S	SLC52A2_ENST00000540505.1_Missense_Mutation_p.P234S|SLC52A2_ENST00000329994.2_Missense_Mutation_p.P322S|SLC52A2_ENST00000402965.1_Missense_Mutation_p.P322S|SLC52A2_ENST00000527078.1_Missense_Mutation_p.P322S|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000530047.1_Missense_Mutation_p.P322S			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	322						integral to plasma membrane	receptor activity|riboflavin transporter activity										TGCTGCCAATCCCCTGGCCTG	0.662000													47	81					0	0	1	0	0
KRT5	3852	broad.mit.edu	37	12	52908793	52908793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52908793C>T	ENST00000252242.4	-	9	2096	c.1706G>A	c.(1705-1707)gGg>gAg	p.G569E		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	569	Ser-rich.|Tail.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTGCTACCCCCGCCACTGCC	0.622000													32	43					0	0	1	0	0
LCE3C	353144	broad.mit.edu	37	1	152573387	152573387	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152573387C>T	ENST00000333881.3	+	1	250	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_178434.2	NP_848521.1	Q5T5A8	LCE3C_HUMAN	late cornified envelope 3C	60					keratinization					lung(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0313)|Kidney(5;0.0367)		ACAGGCACTTCAGGTCCCATC	0.642000													39	35					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214228839	214228839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:214228839G>A	ENST00000413312.1	+	7	955	c.709G>A	c.(709-711)Gga>Aga	p.G237R	SPAG16_ENST00000374309.3_Missense_Mutation_p.G174R|SPAG16_ENST00000447990.1_Missense_Mutation_p.G268R|SPAG16_ENST00000414961.2_3'UTR|SPAG16_ENST00000331683.5_Missense_Mutation_p.G268R|SPAG16_ENST00000272898.7_Missense_Mutation_p.G268R			Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	268					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		ACTGCAAAGAGGACATAGTTA	0.284000													11	23					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141499573	141499573	+	Silent	SNP	C	C	T	rs56022585		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141499573C>T	ENST00000264952.2	+	2	1107	c.970C>T	c.(970-972)Ctg>Ttg	p.L324L		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	324	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						GAATGTGCTTCTGGATGACCT	0.582000													22	30					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	239990240	239990240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239990240G>A	ENST00000345617.3	-	23	3590	c.2799C>T	c.(2797-2799)ttC>ttT	p.F933F	HDAC4_ENST00000543185.1_Silent_p.F517F	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	933	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CCACGGCATCGAAGCCTGATG	0.597000													8	67					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46332449	46332449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46332449G>A	ENST00000245934.7	-	14	2008	c.1764C>T	c.(1762-1764)atC>atT	p.I588I		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	588					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GGCTGGCCAGGATCTTTATGC	0.632000													20	49					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509082	71509082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71509082G>A	ENST00000396073.3	+	9	2220	c.1939G>A	c.(1939-1941)Gag>Aag	p.E647K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	647					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AGACCAGAAGGAGATAGTCCC	0.443000													49	119					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98507826	98507826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98507826C>T	ENST00000359863.4	+	15	1707	c.1498C>T	c.(1498-1500)Cca>Tca	p.P500S	TRRAP_ENST00000355540.3_Missense_Mutation_p.P500S|TRRAP_ENST00000446306.3_Missense_Mutation_p.P500S	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	500	Pro-rich.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTCCCTCCCCAGCCCCTGT	0.662000													23	61					0	0	1	0	0
PARP6	56965	broad.mit.edu	37	15	72548855	72548855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72548855G>A	ENST00000569795.1	-	14	1763	c.1076C>T	c.(1075-1077)cCc>cTc	p.P359L	PARP6_ENST00000413097.2_5'UTR|PARP6_ENST00000260376.7_Missense_Mutation_p.P359L|PARP6_ENST00000287196.9_Missense_Mutation_p.P359L			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	359							NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						CACCACAGAGGGATAAGGCTC	0.468000													23	40					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81698078	81698078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:81698078G>A	ENST00000429644.2	-	5	1263	c.620C>T	c.(619-621)tCt>tTt	p.S207F	GBE1_ENST00000489715.1_Missense_Mutation_p.S166F	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	207					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TTCATGGGAAGAAATTCCCAC	0.333000									Glycogen Storage Disease, type IV				9	17					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141010029	141010029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:141010029C>T	ENST00000277549.5	+	42	5826	c.3257C>T	c.(3256-3258)cCt>cTt	p.P1086L	CACNA1B_ENST00000371357.1_Missense_Mutation_p.P1891L|CACNA1B_ENST00000371363.1_Missense_Mutation_p.P1890L|CACNA1B_ENST00000277551.2_Missense_Mutation_p.P1892L|CACNA1B_ENST00000371355.4_Missense_Mutation_p.P1893L|CACNA1B_ENST00000371372.1_Missense_Mutation_p.P1892L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1892					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTGTTCCACCCTCTGAAGGCC	0.607000													29	103					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14601461	14601461	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14601461G>A	ENST00000274217.3	+	4	378	c.256_splice	c.e4-1	p.R86_splice		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	86										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					TTGGTCCAGGGAACCTCAGTG	0.398000													27	77					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43351929	43351929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43351929G>A	ENST00000290650.4	-	8	1034	c.956C>T	c.(955-957)tCc>tTc	p.S319F	UBR1_ENST00000382177.2_Missense_Mutation_p.S319F	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	319					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GTTCATCCAGGAACCAAGACG	0.333000													14	100					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37725431	37725431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37725431C>T	ENST00000264741.5	+	18	2248	c.1992C>T	c.(1990-1992)ctC>ctT	p.L664L		NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	664					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TCTCCAACCTCGGAGATGATG	0.458000													20	31					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71025259	71025259	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71025259C>A	ENST00000393567.2	-	25	3976	c.3826G>T	c.(3826-3828)Gaa>Taa	p.E1276*		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1276								p.E1276*(1)|p.E1228*(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTTCTTAGTTCTTTTTCTTCA	0.473000													32	78					4.34311e-12	4.36269e-12	1	1	0
GCC2	9648	broad.mit.edu	37	2	109088468	109088468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:109088468C>T	ENST00000309863.6	+	6	3397	c.2683C>T	c.(2683-2685)Cat>Tat	p.H895Y		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	895					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						AAGTGAAATCCATAATGAAAA	0.294000													17	70					0	0	1	0	0
UBE2E2	7325	broad.mit.edu	37	3	23250314	23250314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:23250314G>A	ENST00000396703.1	+	2	304	c.124G>A	c.(124-126)Gag>Aag	p.E42K	UBE2E2_ENST00000425792.1_Missense_Mutation_p.E42K	NM_152653.3	NP_689866.1	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	42					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(2)	10						CAAGAAAAAGGAGGGAAAAAT	0.388000													16	50					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8200926	8200926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8200926G>A	ENST00000600128.1	-	13	1924	c.1510C>T	c.(1510-1512)Cgc>Tgc	p.R504C	FBN3_ENST00000601739.1_Missense_Mutation_p.R504C|FBN3_ENST00000270509.2_Missense_Mutation_p.R504C			Q75N90	FBN3_HUMAN	fibrillin 3	504	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TTGACACAGCGGCCCAGGTGA	0.632000													7	25					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158585167	158585167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158585167C>T	ENST00000368148.3	-	48	6807	c.6627G>A	c.(6625-6627)atG>atA	p.M2209I	SPTA1_ENST00000368147.3_Missense_Mutation_p.M2206I	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2209					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTGACGCTTCATCGCCTGGA	0.483000													52	120					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149493797	149493797	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149493797G>A	ENST00000378016.2	+	0	6793							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGCTCGGATGAGGAGGGCTG	0.642000													4	13					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144918897	144918897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:144918897C>T	ENST00000529945.1	-	6	2217	c.1778G>A	c.(1777-1779)cGa>cAa	p.R593Q	PDE4DIP_ENST00000313431.9_Missense_Mutation_p.R593Q|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.R217Q|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R430Q|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.R496Q|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.R430Q|PDE4DIP_ENST00000369359.4_Missense_Mutation_p.R567Q|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R567Q|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.R430Q|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.R430Q			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	430					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCCTGGGTTCGAATCTCATT	0.438000			T	PDGFRB	MPD								106	896					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56127840	56127840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56127840G>A	ENST00000303039.3	+	1	150	c.118G>A	c.(118-120)Gca>Aca	p.A40T		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					GCTGACCATGGCAGGGAACCT	0.498000													49	114					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48385910	48385910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48385910C>T	ENST00000224600.4	-	2	3295	c.3182G>A	c.(3181-3183)aGg>aAg	p.R1061K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1061	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CACCAGCAGCCTGGAGACCTG	0.537000													38	114					0	0	1	0	0
ZNF157	7712	broad.mit.edu	37	X	47272290	47272290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:47272290C>T	ENST00000377073.3	+	4	904	c.818C>T	c.(817-819)cCc>cTc	p.P273L		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	273					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						GGGGAGAAACCCTATGAATGT	0.448000													20	11					0	0	1	0	0
LMBR1	64327	broad.mit.edu	37	7	156518469	156518469	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:156518469G>A	ENST00000353442.4	-	13	1292	c.1056C>T	c.(1054-1056)atC>atT	p.I352I	LMBR1_ENST00000540390.1_Silent_p.I331I|LMBR1_ENST00000359422.4_Silent_p.I200I|LMBR1_ENST00000354505.4_Silent_p.I393I|LMBR1_ENST00000461603.1_5'UTR	NM_022458.3	NP_071903.2	Q8WVP7	LMBR1_HUMAN	limb development membrane protein 1	352						integral to membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	18	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		AAATCAAAATGATTTCAAGCG	0.403000													24	53					0	0	1	0	0
VASH2	79805	broad.mit.edu	37	1	213147299	213147299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:213147299C>T	ENST00000366968.4	+	8	1037	c.687C>T	c.(685-687)atC>atT	p.I229I	VASH2_ENST00000366967.2_Silent_p.I190I|VASH2_ENST00000366966.2_Silent_p.I229I|VASH2_ENST00000366965.2_Silent_p.I250I|VASH2_ENST00000517399.1_Silent_p.I294I|VASH2_ENST00000271776.4_3'UTR	NM_001136474.1	NP_001129946.1	Q86V25	VASH2_HUMAN	vasohibin 2	294					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		TCCTTCAGATCCTGAAACCTG	0.587000													17	29					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44639169	44639169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44639169C>T	ENST00000372330.3	+	3	438	c.419C>T	c.(418-420)gCc>gTc	p.A140V		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	140					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	ATTGACGACGCCTTTGCCCGC	0.617000													17	40					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210574720	210574720	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:210574720C>T	ENST00000360351.4	+	12	5321	c.4815C>T	c.(4813-4815)acC>acT	p.T1605T	MAP2_ENST00000361559.4_Silent_p.T249T|MAP2_ENST00000475600.1_3'UTR|MAP2_ENST00000392194.1_Silent_p.T249T|MAP2_ENST00000447185.1_Silent_p.T1601T|MAP2_ENST00000199940.6_Silent_p.T306T	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1605					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTCCTGGCACCCCACCAAGTT	0.562000													46	98					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52000608	52000608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52000608G>A	ENST00000291707.3	-	6	1552	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	SIGLEC12_ENST00000598614.1_Silent_p.F381F	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	499					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CTCACACAACGAAGATGATGC	0.572000													33	79					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104239109	104239109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104239109G>A	ENST00000374851.1	-	4	1413	c.266C>T	c.(265-267)tCa>tTa	p.S89L	RP11-490D19.6_ENST00000431507.1_RNA|TMEM246_ENST00000374847.1_Missense_Mutation_p.S89L|RP11-490D19.6_ENST00000450109.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374848.3_Missense_Mutation_p.S89L			Q9BRR3	CI125_HUMAN	transmembrane protein 246	89						integral to membrane		p.S89L(1)									AATGGGCACTGAGCCATTGGC	0.577000													17	24					0	0	1	0	0
IMPAD1	54928	broad.mit.edu	37	8	57890620	57890620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57890620G>A	ENST00000262644.4	-	3	893	c.635C>T	c.(634-636)tCc>tTc	p.S212F		NM_017813.4	NP_060283.3	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	212						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				TGTATATTCGGAAAATGGCTT	0.338000													47	131					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168838897	168838897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168838897G>A	ENST00000464456.1	-	6	1715	c.515C>T	c.(514-516)tCg>tTg	p.S172L	MECOM_ENST00000433243.2_Missense_Mutation_p.S173L|MECOM_ENST00000472280.1_Missense_Mutation_p.S173L|MECOM_ENST00000392736.3_Missense_Mutation_p.S172L|MECOM_ENST00000494292.1_Missense_Mutation_p.S360L|MECOM_ENST00000468789.1_Missense_Mutation_p.S172L|MECOM_ENST00000264674.3_Missense_Mutation_p.S237L|MECOM_ENST00000460814.1_Missense_Mutation_p.S172L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity	p.S172L(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GAGGCCCGACGAAGTGGCAAA	0.552000													13	59					0	0	1	0	0
SLC29A2	3177	broad.mit.edu	37	11	66136562	66136562	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66136562G>A	ENST00000357440.2	-	4	612	c.384C>T	c.(382-384)tcC>tcT	p.S128S	SLC29A2_ENST00000311161.7_Silent_p.S128S|SLC29A2_ENST00000544554.1_Silent_p.S128S|SLC29A2_ENST00000546034.1_Silent_p.S128S	NM_001532.2	NP_001523.2	Q14542	S29A2_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 2	128					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			breast(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10						CCATGGTGATGGAGAAGAAGG	0.607000													3	5					0	0	1	0	0
ZNF675	171392	broad.mit.edu	37	19	23836763	23836763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23836763G>A	ENST00000359788.4	-	4	1140	c.972C>T	c.(970-972)tcC>tcT	p.S324S	ZNF675_ENST00000600313.1_Intron|ZNF675_ENST00000596211.1_Intron|ZNF675_ENST00000601935.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	324					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TAAGGGTTGAGGATTGGGTAA	0.368000													15	85					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49001530	49001530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49001530C>T	ENST00000600059.1	-	11	3023	c.2796G>A	c.(2794-2796)ggG>ggA	p.G932G	LMTK3_ENST00000270238.3_Silent_p.G961G					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTCTCTGGTCCCCGTTCTCCA	0.642000													25	52					0	0	1	0	0
CCDC81	60494	broad.mit.edu	37	11	86126188	86126188	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:86126188C>T	ENST00000278487.3	+	12	1808	c.729C>T	c.(727-729)ccC>ccT	p.P243P	CCDC81_ENST00000354755.1_Silent_p.P418P|CCDC81_ENST00000528728.1_Silent_p.P243P|CCDC81_ENST00000445632.2_Silent_p.P508P			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	508										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				CCTCTGAGCCCATCTTTGGTA	0.458000													21	81					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013176	107013176	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107013176G>A	ENST00000390625.2	-	0	198																											AGCTGTACAGGAGAGTCTCAG	0.547000													26	85					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169108548	169108548	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169108548T>G	ENST00000359299.3	+	12	1124	c.938T>G	c.(937-939)cTg>cGg	p.L313R		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	313							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		AAGAAAGCACTGCTTGCCATC	0.338000													17	57					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247768993	247768993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247768993C>T	ENST00000320002.2	+	1	138	c.106C>T	c.(106-108)Ctc>Ttc	p.L36F	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTTCTTCTACCTCCTGACCCT	0.443000													68	176					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18705913	18705913	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18705913C>T	ENST00000406451.3	+	12	1686	c.1536C>T	c.(1534-1536)gaC>gaT	p.D512D	HDAC9_ENST00000401921.1_Silent_p.D471D|HDAC9_ENST00000406072.1_Silent_p.D499D|HDAC9_ENST00000417496.2_Silent_p.D510D|HDAC9_ENST00000428307.2_Silent_p.D468D|HDAC9_ENST00000456174.2_Silent_p.D484D|HDAC9_ENST00000524023.1_Silent_p.D435D|HDAC9_ENST00000441542.2_Silent_p.D515D|HDAC9_ENST00000405010.3_Silent_p.D512D|HDAC9_ENST00000432645.2_Silent_p.D512D	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	512					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TTCAGGGGGACCAGGCGATGC	0.537000											OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	150					0	0	1	0	0
DRAM1	55332	broad.mit.edu	37	12	102302023	102302023	+	Silent	SNP	C	C	T	rs61748065		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102302023C>T	ENST00000258534.8	+	4	841	c.402C>T	c.(400-402)gtC>gtT	p.V134V	DRAM1_ENST00000544152.1_Intron	NM_018370.2	NP_060840.2	Q8N682	DRAM1_HUMAN	DNA-damage regulated autophagy modulator 1	134					apoptosis|autophagy	integral to membrane|lysosomal membrane		p.V28V(2)		central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)	12						TCTGTGGTGTCGTGTACACGC	0.498000													17	120					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96944880	96944880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96944880G>A	ENST00000267584.4	+	15	1678	c.1634G>A	c.(1633-1635)gGg>gAg	p.G545E		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	545					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		ATCGTGGCGGGGACCCACTAC	0.502000													27	75					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39447062	39447062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39447062G>A	ENST00000280481.7	+	17	8383	c.8167G>A	c.(8167-8169)Gaa>Aaa	p.E2723K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2723					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCCAGAGGCTGAACTTCAAGG	0.403000													18	57					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	140990874	140990874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:140990874C>T	ENST00000389484.3	-	91	14652	c.13681G>A	c.(13681-13683)Gta>Ata	p.V4561I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4561					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTGCATATACCGGATTGGAG	0.323000										TSP Lung(27;0.18)			18	45					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	868150	868150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:868150G>A	ENST00000325464.1	-	16	2735	c.2585C>T	c.(2584-2586)cCc>cTc	p.P862L	MED16_ENST00000395808.3_3'UTR|MED16_ENST00000269814.4_3'UTR|MED16_ENST00000589119.1_Missense_Mutation_p.P862L|MED16_ENST00000312090.6_3'UTR	NM_005481.2	NP_005472.2	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	862					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGGTCCTGGGAGAGTGGTG	0.682000													5	17					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26918769	26918769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26918769G>A	ENST00000321765.5	-	4	1716	c.1384C>T	c.(1384-1386)Cct>Tct	p.P462S		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	462					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					TCTGGGTGAGGGACAGCCAGC	0.542000													35	54					0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76627229	76627229	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76627229C>T	ENST00000264917.5	+	5	698	c.653C>T	c.(652-654)tCg>tTg	p.S218L	PDE8B_ENST00000346042.3_Missense_Mutation_p.S218L|PDE8B_ENST00000342343.4_Missense_Mutation_p.S198L|PDE8B_ENST00000340978.3_Missense_Mutation_p.S218L|PDE8B_ENST00000333194.4_Missense_Mutation_p.S218L	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	218					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TGCTGCAGATCGGATGACCAT	0.502000													44	166					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300136	18300136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18300136G>A	ENST00000441493.2	-	26	5643	c.5291C>T	c.(5290-5292)cCc>cTc	p.P1764L		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1764						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CCCGCTGGAGGGGGTGCTGGG	0.652000													7	21					0	0	1	0	0
MCHR1	2847	broad.mit.edu	37	22	41077897	41077897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41077897G>A	ENST00000249016.4	+	2	1930	c.1234G>A	c.(1234-1236)Gct>Act	p.A412T	MCHR1_ENST00000381433.2_Missense_Mutation_p.A286T|MCHR1_ENST00000498400.1_3'UTR	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	412					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						CGCTCAGACGGCTGACGAGGA	0.607000													11	86					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898953	36898953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36898953G>A	ENST00000301807.6	-	12	2375	c.478C>T	c.(478-480)Ctt>Ttt	p.L160F	TRANK1_ENST00000429976.2_Missense_Mutation_p.L710F|TRANK1_ENST00000428977.2_Missense_Mutation_p.L160F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	710					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GAGCTCTGAAGACAGTCCTCT	0.557000													18	50					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17488005	17488005	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17488005G>A	ENST00000252590.4	-	1	154	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	31						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TGAGGGAGACGAAGAGGAAGA	0.607000													31	75					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61587119	61587119	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61587119G>A	ENST00000238508.3	+	5	529	c.470G>A	c.(469-471)tGg>tAg	p.W157*		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				ATCAACTCTTGGGTTGAAAGA	0.393000													28	77					0	0	1	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54639208	54639208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54639208C>T	ENST00000230640.5	+	8	1085	c.831C>T	c.(829-831)gtC>gtT	p.V277V	SKIV2L2_ENST00000545714.1_Silent_p.V176V	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	277	Helicase ATP-binding.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				CTGATAACGTCCACTATGTCT	0.353000													29	93					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39645728	39645728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39645728C>T	ENST00000265708.4	-	9	788	c.685G>A	c.(685-687)Gag>Aag	p.E229K	ADAM2_ENST00000379853.2_Intron|ADAM2_ENST00000347580.4_Missense_Mutation_p.E210K|ADAM2_ENST00000521880.1_Missense_Mutation_p.E229K	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	229	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ATCCAAAGCTCCAATGAAGAC	0.274000													17	86					0	0	1	0	0
RHBG	57127	broad.mit.edu	37	1	156351651	156351651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156351651G>A	ENST00000400992.2	+	6	1167	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	RHBG_ENST00000451864.2_Intron|RHBG_ENST00000368249.1_Missense_Mutation_p.E299K|RHBG_ENST00000255013.3_Missense_Mutation_p.E230K|RHBG_ENST00000368246.2_Missense_Mutation_p.E299K|RHBG_ENST00000537040.1_Missense_Mutation_p.E137K			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	299					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					GACCTCAAGTGAAATGATGCT	0.557000													24	66					0	0	1	0	0
NIM1K	167359	broad.mit.edu	37	5	43280253	43280253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:43280253G>A	ENST00000512796.1	+	4	2232	c.733G>A	c.(733-735)Gag>Aag	p.E245K	NIM1_ENST00000326035.2_Missense_Mutation_p.E245K			Q8IY84	NIM1_HUMAN		245	Protein kinase.						ATP binding|magnesium ion binding|protein serine/threonine kinase activity										CTTCCGGGACGAGCACTACAT	0.527000													34	79					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142643391	142643391	+	Missense_Mutation	SNP	C	C	T	rs61729041		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142643391C>T	ENST00000355265.2	-	11	1691	c.1217G>A	c.(1216-1218)cGa>cAa	p.R406Q	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	406			R -> Q (in KEL26 antigen).		proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					CTTCATCCATCGTGGGCGGGC	0.562000													12	23					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52129363	52129363	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52129363C>T	ENST00000222107.4	-	8	1524	c.1386G>A	c.(1384-1386)gtG>gtA	p.V462V	SIGLEC5_ENST00000599649.1_Silent_p.V462V|SIGLEC5_ENST00000429354.3_Silent_p.V462V|SIGLEC5_ENST00000570106.2_Silent_p.V462V|SIGLEC5_ENST00000534261.2_Silent_p.V462V			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	462					cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TGCGGGCTTTCACTCTAAGGA	0.522000													9	72					0	0	1	0	0
CHRM1	1128	broad.mit.edu	37	11	62677518	62677518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62677518C>T	ENST00000306960.3	-	2	1596	c.1055G>A	c.(1054-1056)cGg>cAg	p.R352Q	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	352					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	GAAGGTCTTCCGCTTGGCCAG	0.597000													11	30					0	0	1	0	0
FUT4	2526	broad.mit.edu	37	11	94277910	94277910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94277910C>T	ENST00000358752.2	+	1	894	c.611C>T	c.(610-612)gCc>gTc	p.A204V		NM_002033.3	NP_002024.1	P22083	FUT4_HUMAN	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	204					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGCGATAGCGCCCCGAGGCCG	0.741000													3	8					0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978476	10978476	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10978476G>A	ENST00000240619.2	-	1	481	c.393C>T	c.(391-393)ttC>ttT	p.F131F		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	131					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						ATACTATCATGAAGGGAAGAA	0.348000													22	45					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331096	85331096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85331096C>T	ENST00000440886.1	-	1	746	c.708G>A	c.(706-708)aaG>aaA	p.K236K	LPAR3_ENST00000370611.3_Silent_p.K236K|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	236					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						TCTTCATTAGCTTCATGGGTG	0.498000													17	21					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160114869	160114869	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:160114869G>A	ENST00000327245.5	-	5	1059	c.213C>T	c.(211-213)acC>acT	p.T71T	ATP10B_ENST00000518411.1_5'UTR|CTC-529G1.1_ENST00000524198.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	71					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGTTGTGCAGGTTCTGTTGC	0.473000													47	152					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735225	140735225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140735225C>T	ENST00000571252.1	+	1	458	c.458C>T	c.(457-459)cCt>cTt	p.P153L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGATTTCCTCTTCCTGAA	0.458000													7	35					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155790444	155790444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155790444G>A	ENST00000437809.1	-	6	1089	c.967C>T	c.(967-969)Cct>Tct	p.P323S	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Missense_Mutation_p.P323S|GON4L_ENST00000368331.1_Missense_Mutation_p.P323S|GON4L_ENST00000271883.5_Missense_Mutation_p.P323S			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	323					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTCATTTTAGGCTCCTAAGGA	0.393000													21	57					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716834	13716834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13716834G>A	ENST00000279593.3	-	13	3547	c.3338C>T	c.(3337-3339)cCg>cTg	p.P1113L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1113					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGAGCGGGGCGGTCGGCGACG	0.607000													21	46					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81914540	81914540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81914540C>T	ENST00000359376.3	+	8	888	c.674C>T	c.(673-675)tCg>tTg	p.S225L		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	225					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						AAAAAGGATTCGTCCGTGTTC	0.507000													24	94					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233397849	233397849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233397849G>A	ENST00000258229.8	-	3	656	c.422C>T	c.(421-423)cCc>cTc	p.P141L	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	141						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GCAGCGGAGGGGAGGCGTGGA	0.488000													16	163					0	0	1	0	0
MTHFSD	64779	broad.mit.edu	37	16	86575416	86575416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:86575416G>A	ENST00000322911.6	-	7	615	c.565C>T	c.(565-567)Cct>Tct	p.P189S	MTHFSD_ENST00000360900.6_Missense_Mutation_p.P190S|MTHFSD_ENST00000546093.1_Missense_Mutation_p.P27S|MTHFSD_ENST00000381214.5_Missense_Mutation_p.P190S|MTHFSD_ENST00000543303.2_Missense_Mutation_p.P189S	NM_001159377.1|NM_022764.2	NP_001152849.1|NP_073601.2	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	190					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						AGCTCTTCAGGGATGTCCACG	0.592000													6	34					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45711088	45711088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45711088C>T	ENST00000291582.5	+	8	1117	c.990C>T	c.(988-990)atC>atT	p.I330I	AIRE_ENST00000329347.4_Silent_p.I123I|AIRE_ENST00000355347.4_Silent_p.I123I	NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	330					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		TCCGGGAGATCCCCAGGTGAG	0.701000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				8	24					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156917205	156917205	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156917205G>A	ENST00000368194.3	-	26	3418	c.2379C>T	c.(2377-2379)ctC>ctT	p.L793L	ARHGEF11_ENST00000361409.2_Silent_p.L753L|ARHGEF11_ENST00000315174.8_Silent_p.L169L	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	753	DH.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCAGGACCCGGAGTGTGCGCA	0.562000													15	26					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24775279	24775279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24775279G>A	ENST00000221166.5	+	3	2693	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	NEFM_ENST00000521540.1_Intron|NEFM_ENST00000433454.2_Silent_p.E261E|NEFM_ENST00000437366.2_Intron|NEFM_ENST00000518131.1_Intron			P07197	NFM_HUMAN	neurofilament, medium polypeptide	637	6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK].|Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CAGTGGAAGAGAAAGGCAAGT	0.507000													34	115					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272394	52272394	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52272394C>T	ENST00000598776.1	+	2	1255	c.483C>T	c.(481-483)ttC>ttT	p.F161F	FPR2_ENST00000340023.6_Silent_p.F161F|FPR2_ENST00000598953.1_Silent_p.F161F	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	161					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						TGCCAGTTTTCCTCTTTTTGA	0.517000													46	86					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69046410	69046410	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:69046410G>A	ENST00000288368.4	+	32	4160	c.3883G>A	c.(3883-3885)Gaa>Aaa	p.E1295K		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1295					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CAACAGCAAGGAAAATGAGAT	0.498000													36	63					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129913387	129913387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129913387C>T	ENST00000368654.3	-	7	1660	c.1285G>A	c.(1285-1287)Gat>Aat	p.D429N	MKI67_ENST00000368653.3_Intron	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	429					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ACTTCCACATCTGTAGGAATA	0.428000													40	105					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17886947	17886947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17886947C>T	ENST00000594202.1	+	16	1438	c.1159C>T	c.(1159-1161)Ctc>Ttc	p.L387F	FCHO1_ENST00000597512.1_Missense_Mutation_p.L394F|FCHO1_ENST00000596536.1_Missense_Mutation_p.L387F|FCHO1_ENST00000600676.1_Missense_Mutation_p.L387F|FCHO1_ENST00000539407.1_Missense_Mutation_p.L387F|FCHO1_ENST00000596951.1_Missense_Mutation_p.L387F|FCHO1_ENST00000252771.7_Missense_Mutation_p.L387F|FCHO1_ENST00000595033.1_Missense_Mutation_p.L337F|FCHO1_ENST00000389133.4_Missense_Mutation_p.L387F	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	387										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CGCGGGCAGCCTCATCCTTCC	0.672000													10	142					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50383660	50383660	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50383660G>A	ENST00000221543.5	+	4	618		c.e4+1		TBC1D17_ENST00000598789.1_Splice_Site|TBC1D17_ENST00000535102.2_Splice_Site	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17							intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCCACGAGAGGTAGGCTGAGG	0.597000													18	31					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156631964	156631964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156631964C>T	ENST00000296518.7	+	6	856	c.647C>T	c.(646-648)cCc>cTc	p.P216L	GUCY1A3_ENST00000393832.3_5'UTR|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.P216L|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.P216L|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.P216L|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.P216L|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.P216L			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	216					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTGATTCTTCCCGGCATCATA	0.463000													43	92					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43585168	43585168	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43585168C>T	ENST00000406487.1	-	2	393	c.295G>A	c.(295-297)Gaa>Aaa	p.E99K		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	99	Ig-like V-type.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				TATGCTGTTTCTCGTCCACTA	0.453000													123	341					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760614	19760614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19760614G>A	ENST00000357324.6	-	18	2497	c.2471C>T	c.(2470-2472)cCc>cTc	p.P824L	ATP13A1_ENST00000291503.5_Missense_Mutation_p.P706L	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	824					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CAGCTGCTGGGGGTCGGTGGC	0.687000													7	40					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62376529	62376529	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62376529G>A	ENST00000394773.2	-	7	1141	c.834C>T	c.(832-834)gcC>gcT	p.A278A	EML3_ENST00000529309.1_Silent_p.A278A|EML3_ENST00000278845.4_Silent_p.A279A|EML3_ENST00000494176.2_Silent_p.A250A|EML3_ENST00000531557.1_Silent_p.A61A	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	278						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CCACCACACAGGCGATAAAGT	0.607000													70	185					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32041710	32041710	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32041710G>A	ENST00000375244.3	-	12	4596	c.4395C>T	c.(4393-4395)acC>acT	p.T1465T	TNXB_ENST00000375247.2_Silent_p.T1465T			P22105	TENX_HUMAN	tenascin XB	1552	Fibronectin type-III 7.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TGGCTGGAGGGGTCTCTTCTT	0.522000													9	13					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128482973	128482973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128482973G>A	ENST00000325888.8	+	16	2776	c.2515G>A	c.(2515-2517)Ggc>Agc	p.G839S	FLNC_ENST00000346177.6_Missense_Mutation_p.G839S	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	839					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ACCAGGGGCGGGCCGCTACAC	0.592000													4	46					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168107590	168107590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168107590C>T	ENST00000409195.1	+	9	9777	c.9688C>T	c.(9688-9690)Cgt>Tgt	p.R3230C	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R3230C|XIRP2_ENST00000409273.1_Missense_Mutation_p.R3008C|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3055					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATAGAAACTCGTGGTAGGGA	0.448000													30	74					0	0	1	0	0
GDF6	392255	broad.mit.edu	37	8	97157007	97157007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:97157007C>T	ENST00000287020.5	-	2	1251	c.1152G>A	c.(1150-1152)gaG>gaA	p.E384E		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	384					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					CGCATACACCCTCGCAGTGAT	0.637000													18	24					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102869555	102869555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102869555G>A	ENST00000456098.1	-	2	304	c.86C>T	c.(85-87)tCc>tTc	p.S29F	IGF1_ENST00000392904.1_Missense_Mutation_p.S29F|IGF1_ENST00000424202.2_Missense_Mutation_p.S13F|IGF1_ENST00000307046.8_Missense_Mutation_p.S29F|IGF1_ENST00000337514.6_Missense_Mutation_p.S29F	NM_001111283.1	NP_001104753.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	29					anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						GAGATGCGAGGAGGACATGGT	0.597000													4	24					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142479923	142479923	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142479923G>A	ENST00000603901.1	+	0	55					NR_001296.3																						TGTCCCCTTTGATGATGATGA	0.547000													75	270					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138378212	138378212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:138378212C>T	ENST00000409968.1	+	20	3893	c.3715C>T	c.(3715-3717)Ccc>Tcc	p.P1239S	THSD7B_ENST00000272643.3_Missense_Mutation_p.P1242S|THSD7B_ENST00000413152.2_Missense_Mutation_p.P1211S|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATGAGCATTCCCTGCTTGGT	0.468000													70	135					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85711043	85711043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85711043C>T	ENST00000322366.6	-	22	3912	c.3505G>A	c.(3505-3507)Gag>Aag	p.E1169K	WDFY3_ENST00000295888.4_Missense_Mutation_p.E1169K			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1169						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AATGAGGACTCTTCACTAAAA	0.388000													18	53					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515802	140515802	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140515802C>T	ENST00000231134.5	+	1	1003	c.786C>T	c.(784-786)gtC>gtT	p.V262V		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		262	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTTAGTTGTCGTTGTCTCCG	0.453000													130	258					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78594328	78594328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:78594328C>T	ENST00000397909.2	+	38	6964	c.6791C>T	c.(6790-6792)tCt>tTt	p.S2264F	NAV3_ENST00000541270.1_Missense_Mutation_p.S94F|NAV3_ENST00000228327.6_Missense_Mutation_p.S2242F|NAV3_ENST00000536525.2_Missense_Mutation_p.S2242F|NAV3_ENST00000266692.7_Missense_Mutation_p.S2065F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2264						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TGGAACTATTCTTTAGTACCT	0.338000										HNSCC(70;0.22)			36	69					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83610752	83610752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83610752G>A	ENST00000265362.3	-	14	1851	c.1537C>T	c.(1537-1539)Cct>Tct	p.P513S	SEMA3A_ENST00000436949.1_Missense_Mutation_p.P513S	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	513	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CGGTGTAAAGGGAGCTGGGCA	0.463000													6	50					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21145600	21145600	+	Silent	SNP	C	C	T	rs141077519		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21145600C>T	ENST00000261383.3	-	7	1061	c.1062G>A	c.(1060-1062)ctG>ctA	p.L354L	DNAH3_ENST00000415178.1_Silent_p.L354L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	354	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACAGTTCTTTCAGCCTGAGCA	0.527000													29	102					0	0	1	0	0
SLC35G2	80723	broad.mit.edu	37	3	136573347	136573347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:136573347G>A	ENST00000446465.2	+	2	673	c.45G>A	c.(43-45)gtG>gtA	p.V15V	RP11-85F14.5_ENST00000474250.1_RNA|RP11-85F14.5_ENST00000470236.1_RNA|RP11-85F14.5_ENST00000461864.1_RNA|SLC35G2_ENST00000393079.3_Silent_p.V15V	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	15						Golgi apparatus|integral to membrane											AAAAACGGGTGAAAATACATC	0.328000													73	149					0	0	1	0	0
GPALPP1	55425	broad.mit.edu	37	13	45580398	45580398	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:45580398C>T	ENST00000361121.2	+	3	318	c.283C>T	c.(283-285)Ctt>Ttt	p.L95F	RP11-321C24.1_ENST00000437748.2_lincRNA|KIAA1704_ENST00000357537.3_5'UTR|KIAA1704_ENST00000379151.4_Missense_Mutation_p.L95F			Q8IXQ4	K1704_HUMAN		95										breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|prostate(2)|skin(1)	12		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		TGGACCAGCCCTTCCTCCTGG	0.333000													67	255					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237400	29237400	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:29237400C>T	ENST00000382535.3	+	2	1284	c.915C>T	c.(913-915)tcC>tcT	p.S305S	FOXG1_ENST00000313071.4_Silent_p.S305S			P55316	FOXG1_HUMAN	forkhead box G1	305				RAGSLYWPMSPFLSLHHPR -> APAPSTGPCRPSCPCTTP (in Ref. 1; CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GCGCCGGCTCCCTCTACTGGC	0.701000													41	131					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803193	54803193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54803193C>T	ENST00000391745.1	-	8	851	c.535G>A	c.(535-537)Gat>Aat	p.D179N	LILRA3_ENST00000391744.3_Intron|LILRA3_ENST00000251390.3_Missense_Mutation_p.D162N					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGTGTTCATCTTCTCCTTCC	0.577000													68	105					0	0	1	0	0
KRTAP12-1	353332	broad.mit.edu	37	21	46102014	46102014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46102014C>T	ENST00000391617.1	-	1	64	c.25G>A	c.(25-27)Ggc>Agc	p.G9S	TSPEAR_ENST00000323084.4_Intron	NM_181686.1	NP_859014.1	P59990	KR121_HUMAN	keratin associated protein 12-1	9						keratin filament				kidney(1)|large_intestine(1)|lung(1)|skin(2)	5						GGCTGGCAGCCCGAGGAGCAG	0.657000													19	46					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417399	150417399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150417399C>T	ENST00000307194.5	+	3	447	c.307C>T	c.(307-309)Cac>Tac	p.H103Y		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAGAGAGGTCACTGCTACCT	0.642000													15	49					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83095854	83095854	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83095854C>T	ENST00000307792.3	-	4	867	c.400G>A	c.(400-402)Ggt>Agt	p.G134S	SEMA3E_ENST00000427262.1_Missense_Mutation_p.G74S	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	134	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GCTCCAGTACCACAGGTCAGA	0.383000													26	58					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57596994	57596994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57596994C>T	ENST00000243077.3	+	69	11208	c.10742C>T	c.(10741-10743)tCc>tTc	p.S3581F		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3581	LDL-receptor class A 27.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGTGAGTTCTCCTGTGCCAAC	0.667000													7	11					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35332721	35332721	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35332721G>A	ENST00000373347.1	-	11	2917	c.2649C>T	c.(2647-2649)atC>atT	p.I883I	DLGAP3_ENST00000235180.4_Silent_p.I883I			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	883					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane		p.I883M(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				TCACATCCTCGATGGAGAGCT	0.582000											OREG0013353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	128					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8654132	8654132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8654132C>T	ENST00000270328.4	-	17	2418	c.2152G>A	c.(2152-2154)Ggg>Agg	p.G718R	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.G718R|ADAMTS10_ENST00000595838.1_Missense_Mutation_p.G205R			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	718	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TCACCGGCCCCAGGTGAGGCT	0.637000													18	54					0	0	1	0	0
GK5	256356	broad.mit.edu	37	3	141904627	141904627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141904627G>A	ENST00000544571.1	-	10	955	c.825C>T	c.(823-825)gtC>gtT	p.V275V	GK5_ENST00000392993.2_Intron			Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	0					glycerol metabolic process		ATP binding|glycerol kinase activity			kidney(1)|large_intestine(1)|lung(7)|urinary_tract(1)	10						CATATCCAGGGACCTTTAACT	0.323000													10	20					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42116018	42116018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42116018C>T	ENST00000457542.2	+	29	4258	c.3972C>T	c.(3970-3972)ttC>ttT	p.F1324F	MAPKBP1_ENST00000514566.1_Intron|MAPKBP1_ENST00000260357.7_Silent_p.F1163F|MAPKBP1_ENST00000221214.6_Silent_p.F1207F|MAPKBP1_ENST00000456763.2_Silent_p.F1330F	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	1330										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AGCCTGGCTTCCCGGTGGGCC	0.612000													49	96					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120764309	120764309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120764309G>A	ENST00000273666.6	+	5	668	c.397G>A	c.(397-399)Gat>Aat	p.D133N	STXBP5L_ENST00000471454.1_Missense_Mutation_p.D133N|STXBP5L_ENST00000492541.1_Missense_Mutation_p.D133N|STXBP5L_ENST00000497029.1_Missense_Mutation_p.D133N|STXBP5L_ENST00000472879.1_Missense_Mutation_p.D133N	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	133					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		AAGTTCAGATGATACACTTCA	0.348000													17	169					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4968016	4968016	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4968016G>A	ENST00000380373.2	-	1	340	c.315C>T	c.(313-315)ttC>ttT	p.F105F	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCCATGAATGAAGAATTCCT	0.443000													53	154					0	0	1	0	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229394	90229394	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90229394G>A	ENST00000390278.2	+	0	234																											CTTCCTCTATGATGCAAAAGA	0.488000													32	76					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72509694	72509694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72509694G>A	ENST00000373208.1	+	16	2389	c.2389G>A	c.(2389-2391)Gaa>Aaa	p.E797K	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.E794K	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	794	Spacer.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						GGATGCCAAGGAAAGCCTCAA	0.642000													13	63					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125192248	125192248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125192248C>T	ENST00000431078.1	+	5	1081	c.717C>T	c.(715-717)gcC>gcT	p.A239A		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	239	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGAGGCTCGCCCTACACCTCA	0.537000													4	15					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207651394	207651394	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207651394C>T	ENST00000367057.3	+	16	3256	c.3067C>T	c.(3067-3069)Ccc>Tcc	p.P1023S	CR2_ENST00000367058.3_Missense_Mutation_p.P964S|CR2_ENST00000458541.2_Missense_Mutation_p.P937S|CR2_ENST00000367059.3_Missense_Mutation_p.P902S	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	964					complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						ATGGAACCCTCCCCTGGCGGT	0.542000													5	31					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	457111	457111	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:457111C>T	ENST00000512944.1	+	5	1343	c.1154C>T	c.(1153-1155)tCc>tTc	p.S385F	EXOC3_ENST00000315013.5_Missense_Mutation_p.S385F	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	396					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACGTACATGTCCACGCTCACT	0.587000													5	25					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40590106	40590106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:40590106G>A	ENST00000342449.3	-	31	3709	c.3631C>T	c.(3631-3633)Cga>Tga	p.R1211*	BRWD1-IT1_ENST00000435608.1_RNA|BRWD1_ENST00000380800.3_Nonsense_Mutation_p.R1211*|BRWD1_ENST00000333229.2_Nonsense_Mutation_p.R1211*	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1211	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AGTCTCATTCGAATTGTGTAA	0.363000													17	58					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21911671	21911671	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:21911671G>A	ENST00000581223.2	+	0	2396					NR_027084.1																						GCCAACCAAAGTCAAAGAAGA	0.453000													2	0					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136062736	136062736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:136062736G>A	ENST00000383202.2	-	30	3640	c.3384C>T	c.(3382-3384)ccC>ccT	p.P1128P	STAG1_ENST00000434713.2_Silent_p.P868P|STAG1_ENST00000536929.1_Silent_p.P712P|STAG1_ENST00000236698.5_Silent_p.P1128P	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1128					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GGTCTCCCATGGGCCGACTGT	0.463000													26	84					0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41032495	41032495	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41032495C>T	ENST00000380620.3	+	5	601	c.9C>T	c.(7-9)ttC>ttT	p.F3F	AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000343118.4_Silent_p.F3F|B3GALT5_ENST00000380618.1_Silent_p.F3F|B3GALT5_ENST00000398714.2_Silent_p.F3F			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	3					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				AGATGGCTTTCCCGAAGATGA	0.423000													34	154					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84363139	84363139	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84363139C>T	ENST00000509231.1	-	1	915	c.836G>A	c.(835-837)tGg>tAg	p.W279*	SATL1_ENST00000395409.3_Nonsense_Mutation_p.W92*|SATL1_ENST00000332921.5_Nonsense_Mutation_p.W92*			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	92	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						GCTTGCACTCCATTGGTTCAT	0.438000													13	51					0	0	1	0	0
SH3GL3	6457	broad.mit.edu	37	15	84257443	84257443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84257443G>A	ENST00000324537.5	+	11	1274	c.782G>A	c.(781-783)cGa>cAa	p.R261Q	SH3GL3_ENST00000427482.2_Missense_Mutation_p.R253Q|SH3GL3_ENST00000434347.1_Missense_Mutation_p.R261Q|SH3GL3_ENST00000535412.1_Missense_Mutation_p.R253Q			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	253					central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						GTCCCCAGACGAGAATACAAG	0.458000													14	79					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2026061	2026061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2026061C>T	ENST00000568546.1	+	12	1262	c.1134C>T	c.(1132-1134)atC>atT	p.I378I		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	378					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						TCTCAGATATCGTCCTGGCCC	0.642000													50	116					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39978641	39978641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39978641G>A	ENST00000321562.4	+	10	1834	c.1730G>A	c.(1729-1731)cGg>cAg	p.R577Q	FKBP10_ENST00000544340.1_Missense_Mutation_p.R350Q	NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	577	EF-hand 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GACGAGGAGCGGGTCCACGAG	0.617000													8	8					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33644589	33644589	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33644589G>A	ENST00000399362.4	-	18	2132	c.1779C>T	c.(1777-1779)tcC>tcT	p.S593S	CLASP2_ENST00000480013.1_Silent_p.S360S|CLASP2_ENST00000313350.6_Silent_p.S366S|CLASP2_ENST00000359576.5_Silent_p.S593S|CLASP2_ENST00000468888.2_Silent_p.S594S|CLASP2_ENST00000539981.1_Silent_p.S345S|CLASP2_ENST00000461133.3_Silent_p.S360S|CLASP2_ENST00000487200.1_Silent_p.S366S|CLASP2_ENST00000307312.7_Silent_p.S82S|CLASP2_ENST00000333778.6_Silent_p.S370S	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	594										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						TTCCTGGAAGGGAACTGGCTT	0.453000													5	7					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103866850	103866850	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103866850G>A	ENST00000302251.5	-	3	886	c.435C>T	c.(433-435)ttC>ttT	p.F145F	PDGFD_ENST00000393158.2_Silent_p.F151F	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	151	CUB.				positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CATCGGACTTGAATGTGATTT	0.368000													8	121					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754377	49754377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49754377G>A	ENST00000304801.3	-	1	676	c.524C>T	c.(523-525)tCc>tTc	p.S175F		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	175					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TCCCACCATGGAACTATGAGC	0.473000													44	61					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139838948	139838948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139838948C>T	ENST00000303045.6	-	6	1368	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K	COL22A1_ENST00000435777.1_Missense_Mutation_p.E308K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	308	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TACCAGTCTTCCTTCCGAGAG	0.507000										HNSCC(7;0.00092)			28	55					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6266847	6266847	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6266847C>T	ENST00000264870.3	-	4	780	c.515G>A	c.(514-516)cGa>cAa	p.R172Q		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	172					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity	p.R172Q(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TCGACTGGTTCGAAGTACGCC	0.458000													55	110					0	0	1	0	0
DERL1	79139	broad.mit.edu	37	8	124034951	124034951	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124034951T>A	ENST00000259512.4	-	5	726	c.426A>T	c.(424-426)gtA>gtT	p.V142V	DERL1_ENST00000405944.3_Silent_p.V142V|DERL1_ENST00000523036.1_Silent_p.V42V|DERL1_ENST00000419562.2_Intron|DERL1_ENST00000519018.1_Silent_p.V42V|RP11-557C18.3_ENST00000521258.1_RNA	NM_001134671.1|NM_024295.4	NP_001128143.1|NP_077271.1	Q9BUN8	DERL1_HUMAN	derlin 1	142					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|intracellular transport of viral proteins in host cell|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	MHC class I protein binding|receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	8	Lung NSC(37;1.06e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			ACCAAAATGATACAATCATGT	0.418000											OREG0018957	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	156					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31473487	31473487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31473487C>T	ENST00000252229.6	+	2	243	c.164C>T	c.(163-165)cCc>cTc	p.P55L	MICB_ENST00000399150.3_Missense_Mutation_p.P55L|MICB_ENST00000538442.1_Missense_Mutation_p.P23L	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	55					antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						GATGGTCAGCCCTTCCTGCGC	0.582000													30	69					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88376921	88376921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:88376921G>A	ENST00000298699.2	-	12	1358	c.1178C>T	c.(1177-1179)cCt>cTt	p.P393L	C12orf50_ENST00000550553.1_Missense_Mutation_p.P354L	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	393										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						TTTTGAAAAAGGAATTCGTTT	0.259000													23	119					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124988220	124988220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124988220C>T	ENST00000522917.1	+	9	972	c.766C>T	c.(766-768)Ccc>Tcc	p.P256S	FER1L6_ENST00000399018.1_Missense_Mutation_p.P256S	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	256	C2 2.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AGAAGGGTTGCCCAAAATGAA	0.498000													47	176					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121341852	121341852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121341852C>T	ENST00000338040.4	+	3	1990	c.1576C>T	c.(1576-1578)Cgt>Tgt	p.R526C		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	526					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		AAACCATTTCCGTCCCCCAGG	0.502000													13	47					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833950	24833950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24833950C>T	ENST00000376451.2	+	15	4561	c.4301C>T	c.(4300-4302)cCc>cTc	p.P1434L	KIAA1217_ENST00000307544.6_Missense_Mutation_p.P901L|KIAA1217_ENST00000376452.3_Missense_Mutation_p.P1182L|KIAA1217_ENST00000458595.1_Missense_Mutation_p.P1157L|KIAA1217_ENST00000376462.1_Missense_Mutation_p.P1072L|KIAA1217_ENST00000376454.3_Missense_Mutation_p.P1751L|KIAA1217_ENST00000396445.1_Missense_Mutation_p.P875L|KIAA1217_ENST00000396446.1_Missense_Mutation_p.P835L			Q5T5P2	SKT_HUMAN	KIAA1217	1751					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						ATGCCTGTCCCCATGAGTGCC	0.577000													59	128					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1119445	1119445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1119445G>A	ENST00000379290.1	+	12	1407	c.1234G>A	c.(1234-1236)Gac>Aac	p.D412N	TTLL10_ENST00000379289.1_Missense_Mutation_p.D412N|TTLL10_ENST00000379288.3_Missense_Mutation_p.D339N			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	412	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCATTCCAGCGACCTCGGCGG	0.597000													58	208					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276773	152276773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152276773C>T	ENST00000368799.1	-	3	10624	c.10589G>A	c.(10588-10590)aGg>aAg	p.R3530K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3530	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGCTTGTCCTGGGCCCCGC	0.577000									Ichthyosis				108	279					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68810291	68810291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68810291G>A	ENST00000508048.1	-	3	230	c.195C>T	c.(193-195)ttC>ttT	p.F65F	TMPRSS11A_ENST00000396188.2_Silent_p.F66F|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000334830.7_Silent_p.F66F			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	66	SEA.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TGCTTTGTCCGAAATTGTTAT	0.333000													34	76					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2049525	2049525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2049525G>A	ENST00000563630.1	-	9	2102	c.1860C>T	c.(1858-1860)ccC>ccT	p.P620P	ZNF598_ENST00000562103.1_Silent_p.P620P|ZNF598_ENST00000431526.1_Silent_p.P675P			Q86UK7	ZN598_HUMAN	zinc finger protein 598	675	Pro-rich.					intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						GGGGTGGGCAGGGGCCGCCGA	0.751000													4	13					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29455196	29455196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29455196C>T	ENST00000389048.3	-	15	3512	c.2606G>A	c.(2605-2607)gGg>gAg	p.G869E	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	869	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GCCGTTTAGCCCTAGAACCGA	0.622000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				30	81					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134049606	134049606	+	Missense_Mutation	SNP	C	C	T	rs140330621		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:134049606C>T	ENST00000359428.5	+	22	3202	c.3058C>T	c.(3058-3060)Cgc>Tgc	p.R1020C	NUP214_ENST00000451030.1_Missense_Mutation_p.R1021C|NUP214_ENST00000411637.2_Missense_Mutation_p.R1010C			P35658	NU214_HUMAN	nucleoporin 214kDa	1020	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CCCCGTGGTTCGCACTCCTTC	0.562000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								44	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179592510	179592510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179592510C>T	ENST00000589042.1	-	68	20019	c.19795G>A	c.(19795-19797)Gga>Aga	p.G6599R	TTN_ENST00000342992.6_Missense_Mutation_p.G5355R|TTN_ENST00000591111.1_Missense_Mutation_p.G6282R|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6282	Ig-like 47.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGTGTTCCTTTTAGTATT	0.393000													48	112					0	0	1	0	0
FAM115A	9747	broad.mit.edu	37	7	143573340	143573340	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143573340G>A	ENST00000479870.1	-	2	570	c.362C>T	c.(361-363)tCc>tTc	p.S121F	FAM115A_ENST00000392900.3_Intron|FAM115A_ENST00000355951.2_Missense_Mutation_p.S121F	NM_001206938.1|NM_001206941.1|NM_014719.2	NP_001193867.1|NP_001193870.1|NP_055534.1	Q9Y4C2	F115A_HUMAN	family with sequence similarity 115, member A	121										NS(1)|endometrium(1)|lung(5)	7	Melanoma(164;0.0903)					AACCCCCAGGGAGTCTTTCAC	0.522000													52	135					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179547468	179547468	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179547468T>A	ENST00000589042.1	-	135	33274	c.33050A>T	c.(33049-33051)gAg>gTg	p.E11017V	TTN_ENST00000342992.6_Missense_Mutation_p.E9773V|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10700V|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10700	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTCCCGCTCCTCGTATTC	0.363000													9	200					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32035662	32035662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32035662G>A	ENST00000375244.3	-	18	6521	c.6320C>T	c.(6319-6321)tCc>tTc	p.S2107F	TNXB_ENST00000375247.2_Missense_Mutation_p.S2107F			P22105	TENX_HUMAN	tenascin XB	2179	Fibronectin type-III 13.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CGAGTCAGGGGAGGATCCTGT	0.682000													36	57					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138000129	138000129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:138000129G>A	ENST00000409968.1	+	10	2431	c.2253G>A	c.(2251-2253)agG>agA	p.R751R	THSD7B_ENST00000272643.3_Silent_p.R751R|THSD7B_ENST00000413152.2_Silent_p.R720R|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTGCCCAAGGATGTGCCAAG	0.478000													21	42					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161021355	161021355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161021355C>T	ENST00000368013.3	-	10	1489	c.1169G>A	c.(1168-1170)cGa>cAa	p.R390Q	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.R390Q|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.R213Q	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	390					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CCGCCCAGCTCGTGGTGTGCC	0.602000													38	77					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	14018779	14018779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14018779G>A	ENST00000279593.3	-	2	573	c.364C>T	c.(364-366)Ccc>Tcc	p.P122S		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	122					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCAGGATGGGGGTGAGAGTC	0.547000													60	133					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47390600	47390600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47390600C>T	ENST00000285039.7	-	28	4053	c.3754G>A	c.(3754-3756)Gag>Aag	p.E1252K	MYO5B_ENST00000587895.1_5'UTR|MYO5B_ENST00000324581.6_Missense_Mutation_p.E393K	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1252					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TCGAGCTCCTCGTGGGCCAGC	0.637000													21	81					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197019875	197019875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197019875C>T	ENST00000367412.1	-	10	1733	c.1690G>A	c.(1690-1692)Gag>Aag	p.E564K	F13B_ENST00000490002.1_5'UTR	NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	564	Sushi 9.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						CAATAGGCCTCCCTAGATCCT	0.338000													15	54					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21709108	21709108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21709108C>T	ENST00000388958.3	+	9	753	c.752C>T	c.(751-753)tCa>tTa	p.S251L	OTOA_ENST00000388956.4_Missense_Mutation_p.S172L|OTOA_ENST00000286149.4_Missense_Mutation_p.S251L	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	251					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		GACTCTGCTTCATGGGTCAGT	0.353000													28	88					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9374249	9374249	+	Silent	SNP	G	G	A	rs1129249		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9374249G>A	ENST00000378501.2	+	15	1353	c.1338G>A	c.(1336-1338)agG>agA	p.R446R	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Silent_p.R446R|PLCB4_ENST00000278655.4_Silent_p.R446R|PLCB4_ENST00000378493.1_Silent_p.R446R|PLCB4_ENST00000334005.3_Silent_p.R446R|PLCB4_ENST00000378473.3_Silent_p.R446R	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	446	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AACCAGGCAGGGCTTTGCCAT	0.453000											OREG0025771	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	61					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200008813	200008813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200008813C>T	ENST00000367362.3	+	2	338	c.92C>T	c.(91-93)tCc>tTc	p.S31F	NR5A2_ENST00000236914.3_Intron	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	31					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					CGACACGGATCCCCCATCCCC	0.647000													30	113					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27309058	27309058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27309058C>T	ENST00000397497.4	+	18	2143	c.1692C>T	c.(1690-1692)ttC>ttT	p.F564F	PTK2B_ENST00000397501.1_Intron|PTK2B_ENST00000544172.1_Intron|PTK2B_ENST00000338238.4_Intron|PTK2B_ENST00000420218.2_Intron|PTK2B_ENST00000346049.5_Intron|PTK2B_ENST00000517339.1_Intron			Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	0	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CGGGGGGTTTCCTCTTGGCAC	0.597000													7	28					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477849	88477849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:88477849G>A	ENST00000267549.3	+	2	1216	c.658G>A	c.(658-660)Gaa>Aaa	p.E220K	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	220					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						GGAAAACAAGGAAAAGAAGAG	0.428000													16	35					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330004	125330004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125330004G>A	ENST00000304865.2	-	1	834	c.753C>T	c.(751-753)ctC>ctT	p.L251L		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TTCCATAAAAGAGCGTCACCA	0.463000													10	35					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151945426	151945426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151945426G>A	ENST00000355193.2	-	14	2311	c.2093C>T	c.(2092-2094)aCc>aTc	p.T698I	KMT2C_ENST00000262189.6_Missense_Mutation_p.T698I					lysine (K)-specific methyltransferase 2C																		GGACACTAAGGTTTCTAGTGG	0.403000													27	75					0	0	1	0	0
HSD17B13	345275	broad.mit.edu	37	4	88235022	88235022	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88235022G>A	ENST00000328546.4	-	5	712	c.648C>T	c.(646-648)ctC>ctT	p.L216L	HSD17B13_ENST00000302219.6_Silent_p.L180L	NM_178135.3	NP_835236.2	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	216						extracellular region	binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		AAACTGGGCAGAGACATGAGG	0.408000													26	48					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56320980	56320980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56320980G>A	ENST00000443188.1	-	5	1706	c.996C>T	c.(994-996)ctC>ctT	p.L332L	NLRP11_ENST00000589093.1_Silent_p.L332L|NLRP11_ENST00000592953.1_Silent_p.L233L|NLRP11_ENST00000360133.3_Silent_p.L332L|NLRP11_ENST00000589824.2_Silent_p.L332L	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	332	NACHT.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ACAGACCCACGAGTATTTCAT	0.527000													9	55					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983591	97983591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97983591G>A	ENST00000383696.2	+	1	504	c.463G>A	c.(463-465)Gaa>Aaa	p.E155K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TATGACCAATGAACTATGCAT	0.363000													44	103					0	0	1	0	0
KCNJ11	3767	broad.mit.edu	37	11	17408585	17408585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17408585C>T	ENST00000339994.4	-	1	1621	c.1054G>A	c.(1054-1056)Gac>Aac	p.D352N	KCNJ11_ENST00000528731.1_Missense_Mutation_p.D265N	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	265						integral to membrane	ATP-activated inward rectifier potassium channel activity			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		AGGCTGTGGTCCTCATCAAGC	0.622000											OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	75					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101276378	101276378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101276378G>A	ENST00000519449.1	-	8	1668	c.1352C>T	c.(1351-1353)cCa>cTa	p.P451L	RNF19A_ENST00000341084.2_Missense_Mutation_p.P451L|RNF19A_ENST00000523255.1_Intron	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	451					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			AAGAGAAATTGGAACTACGCC	0.363000													29	31					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240256738	240256738	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240256738C>T	ENST00000319653.9	+	1	1559	c.1329C>T	c.(1327-1329)atC>atT	p.I443I		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	443					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCCCAGGATCAAGAGGCGGC	0.682000													17	95					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31424183	31424183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31424183C>T	ENST00000389202.2	+	15	1781	c.1732C>T	c.(1732-1734)Ccc>Tcc	p.P578S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	578					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCAGCTCTCCCCCAGGCTGCA	0.597000													46	83					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28610179	28610179	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28610179C>T	ENST00000380982.4	-	11	1392	c.1309_splice	c.e11-1	p.R437_splice	FLT3_ENST00000537084.1_Splice_Site_p.R437_splice|FLT3_ENST00000241453.7_Splice_Site_p.R437_splice			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	437					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTTGAGGTTTCCCTATAGAAA	0.473000			"""Mis, O"""		"""AML, ALL"""								46	97					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21306910	21306910	+	Missense_Mutation	SNP	G	G	A	rs147841357	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21306910G>A	ENST00000602326.1	-	8	846	c.263C>T	c.(262-264)cCc>cTc	p.P88L	EIF4G3_ENST00000356916.3_Missense_Mutation_p.P92L|EIF4G3_ENST00000264211.8_Missense_Mutation_p.P81L|EIF4G3_ENST00000374935.3_Missense_Mutation_p.P81L|EIF4G3_ENST00000374937.3_Missense_Mutation_p.P88L|EIF4G3_ENST00000374927.4_Missense_Mutation_p.P81L|EIF4G3_ENST00000400422.1_Missense_Mutation_p.P81L	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	81					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TTGTTGGGGGGGCCCAACATA	0.433000													9	28					0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191300967	191300967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:191300967C>T	ENST00000392328.1	+	3	536	c.212C>T	c.(211-213)tCc>tTc	p.S71F	MFSD6_ENST00000281416.7_Missense_Mutation_p.S71F	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	71					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						CTTCTAATTTCCAAGGTCTTT	0.398000													39	98					0	0	1	0	0
FTMT	94033	broad.mit.edu	37	5	121188021	121188021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121188021G>A	ENST00000321339.1	+	1	372	c.363G>A	c.(361-363)gaG>gaA	p.E121E		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	121	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		AGTCCCGGGAGGAGACCGAGC	0.572000													18	57					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166961934	166961934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:166961934G>A	ENST00000367872.4	+	4	581	c.337G>A	c.(337-339)Ggc>Agc	p.G113S	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Missense_Mutation_p.G82S	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	113					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						TCTCCTTGGAGGCATTTTTTA	0.353000													21	47					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380736	147380736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:147380736C>T	ENST00000240986.4	+	2	707	c.654C>T	c.(652-654)ttC>ttT	p.F218F	GJA8_ENST00000369235.1_Silent_p.F218F	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	218					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					TGTCCCTATTCCTCAACGTGA	0.592000													23	69					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101608912	101608912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101608912G>A	ENST00000311812.2	-	10	1083	c.933C>T	c.(931-933)atC>atT	p.I311I	SNX31_ENST00000428383.2_Silent_p.I212I|SNX31_ENST00000519521.1_5'UTR	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	311					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TCTGGAAAACGATGTCCTGGG	0.507000													21	79					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176002773	176002773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176002773G>A	ENST00000510636.1	+	11	1167	c.893G>A	c.(892-894)aGg>aAg	p.R298K	CDHR2_ENST00000261944.5_Missense_Mutation_p.R298K|CDHR2_ENST00000506348.1_Missense_Mutation_p.R298K	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	298	Cadherin 3.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GGGGTGATCAGGGTCAACGGC	0.642000													3	3					0	0	1	0	0
KDELC1	79070	broad.mit.edu	37	13	103443710	103443710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:103443710G>A	ENST00000376004.4	-	5	1079	c.743C>T	c.(742-744)tCa>tTa	p.S248L	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	248						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ATGGATGTTTGAATTGGATTT	0.428000													140	261					0	0	1	0	0
ZFP82	284406	broad.mit.edu	37	19	36884731	36884731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36884731C>T	ENST00000392161.3	-	5	753	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	ZFP82_ENST00000392171.1_Missense_Mutation_p.E171K	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TCCTTACATTCATAGGGTTTA	0.413000													10	73					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129185811	129185811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129185811C>T	ENST00000296266.3	+	9	987	c.795C>T	c.(793-795)atC>atT	p.I265I	IFT122_ENST00000440957.2_Intron|IFT122_ENST00000431818.2_Silent_p.I64I|IFT122_ENST00000504021.1_Intron|IFT122_ENST00000349441.2_Intron|IFT122_ENST00000347300.2_Intron|IFT122_ENST00000507564.1_Intron|IFT122_ENST00000348417.2_Silent_p.I214I	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	214					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TTCAGGAAATCCCTTCCACTC	0.483000													28	103					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54797988	54797988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54797988G>A	ENST00000293379.4	-	15	1767	c.1506C>T	c.(1504-1506)ttC>ttT	p.F502F	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	502					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						ACATGGCGGGGAAGATGGTGA	0.597000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	85					0	0	1	0	0
SCGB2B2	284402	broad.mit.edu	37	19	35085210	35085210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35085210G>A	ENST00000601241.1	-	3	2216	c.116C>T	c.(115-117)tCc>tTc	p.S39F	SCGB2B2_ENST00000595326.1_Intron|SCGB2B2_ENST00000379204.2_Missense_Mutation_p.S39F			Q4G0G5	SCGBL_HUMAN	secretoglobin, family 2B, member 2	39						extracellular region	binding										GAGGTCTTGGGACACATCAAA	0.507000													23	104					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401587	77401587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77401587G>A	ENST00000282849.5	-	4	947	c.529C>T	c.(529-531)Ctc>Ttc	p.L177F	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	177					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GGCGAGATGAGGAATTCATTT	0.468000													22	80					0	0	1	0	0
RAD23B	5887	broad.mit.edu	37	9	110081045	110081045	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:110081045C>A	ENST00000358015.3	+	6	917	c.566C>A	c.(565-567)tCt>tAt	p.S189Y	RAD23B_ENST00000416373.2_Missense_Mutation_p.S117Y	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	189	UBA 1.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						ACGGGTCAGTCTTACGAGAAT	0.403000								Direct reversal of damage;Nucleotide excision repair (NER)					56	98					1.64573e-32	1.65715e-32	1	1	0
NCAN	1463	broad.mit.edu	37	19	19349165	19349165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19349165C>T	ENST00000252575.5	+	11	3397	c.3354C>T	c.(3352-3354)cgC>cgT	p.R1118R	NCAN_ENST00000538881.1_Silent_p.R569R	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1118	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			ACTGCCGCCGCCGCTCCGGCC	0.652000													27	86					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80746087	80746087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80746087G>A	ENST00000458043.2	+	44	5257	c.5251G>A	c.(5251-5253)Gac>Aac	p.D1751N	OTOGL_ENST00000547103.1_Missense_Mutation_p.D1739N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTCACCGGAAGACTTTTGTGA	0.338000													10	17					0	0	1	0	0
SPATA31D4	389761	broad.mit.edu	37	9	84549058	84549058	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84549058G>A	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							GGGGATGCAGGGTTGGGGACA	0.488000													5	7					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3229530	3229530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3229530C>T	ENST00000217939.6	-	7	6868	c.6714G>A	c.(6712-6714)gtG>gtA	p.V2238V		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2238	Ig-like C2-type 6.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTTTCATCACCACATCCACTT	0.527000													39	34					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206610599	206610599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206610599G>A	ENST00000360409.3	+	10	2562	c.1771G>A	c.(1771-1773)Ggc>Agc	p.G591S	NRP2_ENST00000357118.4_Missense_Mutation_p.G591S|NRP2_ENST00000540841.1_Missense_Mutation_p.G591S|NRP2_ENST00000540178.1_Missense_Mutation_p.G591S|NRP2_ENST00000357785.5_Missense_Mutation_p.G591S|NRP2_ENST00000272849.3_Missense_Mutation_p.G591S|NRP2_ENST00000412873.2_Missense_Mutation_p.G591S	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	591	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GGAGGTGCTGGGCTGTGACTG	0.612000													15	48					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3084710	3084710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3084710G>A	ENST00000397461.1	+	21	2945	c.2561G>A	c.(2560-2562)cGa>cAa	p.R854Q	CNTN4_ENST00000397459.2_Missense_Mutation_p.R526Q|CNTN4_ENST00000418658.1_Missense_Mutation_p.R854Q|CNTN4_ENST00000427331.1_Missense_Mutation_p.R854Q|CNTN4_ENST00000448906.2_Missense_Mutation_p.R526Q|CNTN4-AS1_ENST00000442749.2_RNA|CNTN4_ENST00000358480.3_Missense_Mutation_p.R635Q	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	854	Fibronectin type-III 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGAAAAATACGAACAGTTGGA	0.383000													11	39					0	0	1	0	0
EDN1	1906	broad.mit.edu	37	6	12294197	12294197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:12294197G>A	ENST00000379375.5	+	3	524	c.257G>A	c.(256-258)gGa>gAa	p.G86E		NM_001168319.1|NM_001955.4	NP_001161791.1|NP_001946.3	P05305	EDN1_HUMAN	endothelin 1	86					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	13	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				TATGGACTTGGAAGCCCTAGG	0.408000													14	55					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74684153	74684153	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74684153G>A	ENST00000334011.5	+	7	1336	c.1118G>A	c.(1117-1119)cGa>cAa	p.R373Q		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	373	ZP.					nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					CCCAACCTTCGAAACTCCCCA	0.512000													22	59					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37325573	37325573	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:37325573T>G	ENST00000373091.3	-	6	848	c.832A>C	c.(832-834)Aac>Cac	p.N278H	GRIK3_ENST00000373093.4_Missense_Mutation_p.N278H	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	278					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCTGTCAGGTTCACGCCTGAG	0.567000													23	70					0	0	1	0	0
PKD2L2	27039	broad.mit.edu	37	5	137230282	137230282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137230282C>T	ENST00000508638.1	+	4	563	c.508C>T	c.(508-510)Ctt>Ttt	p.L170F	PKD2L2_ENST00000502810.1_Missense_Mutation_p.L170F|PKD2L2_ENST00000350250.4_Missense_Mutation_p.L136F|PKD2L2_ENST00000290431.5_Missense_Mutation_p.L170F|PKD2L2_ENST00000508883.1_Missense_Mutation_p.L170F	NM_001258449.1	NP_001245378.1	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	170						integral to membrane	calcium ion binding|ion channel activity			breast(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	28			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TAATTTTGGCCTTCAAATTAA	0.333000													15	33					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52660491	52660491	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52660491C>T	ENST00000355568.4	-	16	1540	c.1401G>A	c.(1399-1401)tgG>tgA	p.W467*		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	467							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTAACTGCTTCCAATATTCCT	0.363000													23	96					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321967	52321967	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:52321967C>T	ENST00000356297.4	-	17	2317	c.2217G>A	c.(2215-2217)caG>caA	p.Q739Q	PXDNL_ENST00000543296.1_Silent_p.Q739Q	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	739					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCCACGTGGGCTGCTGCAGGT	0.697000													5	28					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184233578	184233578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:184233578C>T	ENST00000403733.3	+	22	3668	c.3469C>T	c.(3469-3471)Cgg>Tgg	p.R1157W	WWC2_ENST00000504005.1_Missense_Mutation_p.R839W|WWC2_ENST00000448232.2_Missense_Mutation_p.R1181W|WWC2_ENST00000513834.1_Missense_Mutation_p.R1108W|WWC2_ENST00000508747.1_Missense_Mutation_p.R285W	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1157										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		GTGTCGGCTCCGGGAGCAGAG	0.542000													24	100					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24808358	24808358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24808358G>A	ENST00000216274.5	-	3	552	c.334C>T	c.(334-336)Cgg>Tgg	p.R112W		NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	112	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		GGCCAGGGCCGAGGGCACTGG	0.602000													29	59					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34962328	34962328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34962328G>A	ENST00000329357.5	+	1	1416	c.1380G>A	c.(1378-1380)tcG>tcA	p.S460S		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	460										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GACACACATCGAGAAAACTCC	0.468000													14	76					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13692161	13692161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13692161G>A	ENST00000265104.4	-	79	13911	c.13807C>T	c.(13807-13809)Ctc>Ttc	p.L4603F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4603					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCTGTCCTGAGATCCACAGCG	0.502000									Kartagener syndrome				32	75					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275978	152275978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152275978C>T	ENST00000368799.1	-	3	11419	c.11384G>A	c.(11383-11385)gGa>gAa	p.G3795E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3795	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCAGACCTTCCCTGGGATGT	0.577000									Ichthyosis				195	490					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73566202	73566202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73566202C>T	ENST00000392550.3	+	15	1857	c.1740C>T	c.(1738-1740)ttC>ttT	p.F580F	LLGL2_ENST00000167462.5_Silent_p.F580F|LLGL2_ENST00000577200.1_Silent_p.F580F	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	580					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			TTCAGCCCTTCGTGTTGGTGC	0.677000													5	13					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94700010	94700010	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94700010C>T	ENST00000304338.3	+	6	691	c.537C>T	c.(535-537)tcC>tcT	p.S179S		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	179						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						CACTTGTTTCCAAGGCACAAC	0.328000													33	108					0	0	1	0	0
FER	2241	broad.mit.edu	37	5	108523217	108523217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:108523217C>T	ENST00000281092.4	+	20	2794	c.2410C>T	c.(2410-2412)Cgc>Tgc	p.R804C	FER_ENST00000438717.2_Missense_Mutation_p.R629C	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	804	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		ACCTGAAAATCGCCCTAAGTT	0.453000													24	64					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116599799	116599799	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:116599799G>T	ENST00000410059.1	+	26	2749	c.2269G>T	c.(2269-2271)Gaa>Taa	p.E757*	DPP10_ENST00000409163.1_Nonsense_Mutation_p.E707*|DPP10_ENST00000310323.8_Nonsense_Mutation_p.E750*|DPP10_ENST00000393147.2_Nonsense_Mutation_p.E761*	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	757					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						CTACCCAGATGAAGGTCATAA	0.383000													11	48					1.08611e-07	1.08924e-07	1	1	0
DYSF	8291	broad.mit.edu	37	2	71901373	71901373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71901373G>A	ENST00000258104.3	+	51	5991	c.5714G>A	c.(5713-5715)cGa>cAa	p.R1905Q	DYSF_ENST00000410041.1_Missense_Mutation_p.R1923Q|DYSF_ENST00000429174.2_Missense_Mutation_p.R1926Q|DYSF_ENST00000409744.1_Missense_Mutation_p.R1913Q|DYSF_ENST00000410020.3_Missense_Mutation_p.R1944Q|DYSF_ENST00000394120.2_Missense_Mutation_p.R1906Q|DYSF_ENST00000409366.1_Missense_Mutation_p.R1927Q|DYSF_ENST00000409582.3_Missense_Mutation_p.R1943Q|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Missense_Mutation_p.R1936Q|DYSF_ENST00000409651.1_Missense_Mutation_p.R1937Q|DYSF_ENST00000409762.1_Missense_Mutation_p.R1922Q	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1905						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATCCCAGCACGAGTGGTGTTC	0.517000													27	56					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185165676	185165676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185165676C>T	ENST00000265026.3	+	5	1285	c.951C>T	c.(949-951)gtC>gtT	p.V317V	MAP3K13_ENST00000535426.1_Silent_p.V173V|MAP3K13_ENST00000446828.1_Silent_p.V110V|MAP3K13_ENST00000443863.1_Silent_p.V173V|MAP3K13_ENST00000424227.1_Silent_p.V317V	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	317	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			CTGGCACGGTCGCATGGATGG	0.448000													6	43					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139657436	139657436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139657436C>T	ENST00000263552.6	+	12	1233	c.695C>T	c.(694-696)tCa>tTa	p.S232L	TBXAS1_ENST00000448866.1_Missense_Mutation_p.S231L|TBXAS1_ENST00000436047.2_Missense_Mutation_p.S232L|TBXAS1_ENST00000414508.2_Missense_Mutation_p.S232L|TBXAS1_ENST00000416849.2_Missense_Mutation_p.S278L|TBXAS1_ENST00000425687.1_Missense_Mutation_p.S164L|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000411653.1_Missense_Mutation_p.S231L|TBXAS1_ENST00000458722.1_Missense_Mutation_p.S277L|TBXAS1_ENST00000336425.5_Missense_Mutation_p.S231L	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	231					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					TTTCAAGTATCATTTCCATCC	0.453000													19	65					0	0	1	0	0
SLC38A9	153129	broad.mit.edu	37	5	54922345	54922345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54922345G>A	ENST00000396865.2	-	16	2254	c.1663C>T	c.(1663-1665)Ctg>Ttg	p.L555L	SLC38A9_ENST00000416547.2_Silent_p.L431L|SLC38A9_ENST00000512595.1_Silent_p.L492L|SLC38A9_ENST00000539768.1_3'UTR|SLC38A9_ENST00000318672.3_Silent_p.L555L|SLC38A9_ENST00000515629.1_Silent_p.L492L	NM_173514.3	NP_775785.2	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	555					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				TGAACAATCAGGTTAGCCACG	0.368000													42	110					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6752834	6752834	+	Silent	SNP	G	G	A	rs148058585		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6752834G>A	ENST00000229243.2	-	6	1041	c.948C>T	c.(946-948)ctC>ctT	p.L316L	ACRBP_ENST00000542357.1_5'UTR|ACRBP_ENST00000414226.2_Silent_p.L283L	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	316				L -> F (in Ref. 1; BAB39388).		acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						GCAGCTGCAGGAGGCTGCAAG	0.587000													23	79					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49411641	49411641	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49411641G>A	ENST00000299191.3	+	2	267		c.e2-1			NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						TGTCTTTTCAGAAGCAAAAGC	0.562000													6	11					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129127538	129127538	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129127538T>C	ENST00000505956.1	-	6	1361	c.1199A>G	c.(1198-1200)aAg>aGg	p.K400R	EFCAB12_ENST00000326085.3_Missense_Mutation_p.K400R	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		CTTACAGAGCTTCCAGCATTG	0.572000													5	10					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147863901	147863901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147863901C>T	ENST00000360693.3	-	7	1256	c.1118G>A	c.(1117-1119)tGg>tAg	p.W373*	HTR4_ENST00000517929.1_Intron|HTR4_ENST00000520514.1_Intron|HTR4_ENST00000314512.6_Intron|HTR4_ENST00000521530.1_Intron|HTR4_ENST00000521735.1_Intron|HTR4_ENST00000377888.3_Intron|HTR4_ENST00000362016.2_Intron|HTR4_ENST00000354217.2_Intron	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	359					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AGGCTTTGTCCAATACCTTGC	0.388000													21	35					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21552454	21552454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:21552454G>A	ENST00000281523.2	-	4	856	c.338C>T	c.(337-339)gCc>gTc	p.A113V	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	113						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						ATTTTTCATGGCTTCCAGTGC	0.463000													29	76					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108297011	108297011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:108297011C>T	ENST00000520734.1	-	6	789	c.504G>A	c.(502-504)caG>caA	p.Q168Q	ANGPT1_ENST00000520052.1_Silent_p.Q167Q|ANGPT1_ENST00000518386.1_Intron			Q15389	ANGP1_HUMAN	angiopoietin 1	368					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGTACTGCCTCTGACTGGTAA	0.403000													16	53					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573709	38573709	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38573709C>T	ENST00000222345.6	+	3	2013	c.1504C>T	c.(1504-1506)Cgc>Tgc	p.R502C		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	502					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCTGGGCGCCCGCTACTACCA	0.627000													19	38					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6999962	6999962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6999962C>T	ENST00000389658.3	-	31	4510	c.4417G>A	c.(4417-4419)Gat>Aat	p.D1473N		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1473	Laminin EGF-like 16.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAACGGAAATCGTGGTCCCCT	0.423000													19	41					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347522	140347522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140347522G>A	ENST00000289269.5	+	1	1703	c.1171G>A	c.(1171-1173)Gac>Aac	p.D391N	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		391	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGTCAATGACCAAGACTC	0.552000													30	69					0	0	1	0	0
CEP70	80321	broad.mit.edu	37	3	138219307	138219307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138219307C>T	ENST00000264982.3	-	15	1737	c.1471G>A	c.(1471-1473)Gaa>Aaa	p.E491K	CEP70_ENST00000481834.1_Missense_Mutation_p.E491K|CEP70_ENST00000484888.1_Missense_Mutation_p.E491K|CEP70_ENST00000542237.1_Missense_Mutation_p.E471K|CEP70_ENST00000489254.1_Missense_Mutation_p.E339K	NM_024491.2	NP_077817.2	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70kDa	491					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	24						GTATAAACTTCATTCATTCGG	0.383000													74	274					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16962339	16962339	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16962339C>T	ENST00000379803.1	+	6	857	c.843C>T	c.(841-843)ccC>ccT	p.P281P	SIN3B_ENST00000596802.1_Silent_p.P281P|SIN3B_ENST00000248054.5_Silent_p.P281P	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	281					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						TGTCTGCACCCGCCAAGGTAC	0.672000													13	72					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67220115	67220115	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67220115G>A	ENST00000312457.2	-	1	85	c.81C>T	c.(79-81)ccC>ccT	p.P27P	CABP4_ENST00000542025.2_3'UTR|CABP4_ENST00000438189.2_5'UTR	NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	27						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P27P(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AGCCACCTTGGGGGTAGGAGT	0.652000													4	36					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917687	48917687	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48917687C>T	ENST00000311378.4	+	2	1566	c.1038C>T	c.(1036-1038)ttC>ttT	p.F346F	WFIKKN2_ENST00000426127.1_Silent_p.F253F|RP11-506D12.5_ENST00000572491.2_RNA	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	346	BPTI/Kunitz inhibitor 1.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCTGGCACTTCGATGCCCAGG	0.622000													25	65					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488383	1488383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1488383G>A	ENST00000345913.4	+	9	1445	c.1354G>A	c.(1354-1356)Gat>Aat	p.D452N	TPO_ENST00000497517.2_3'UTR|TPO_ENST00000349624.3_Missense_Mutation_p.D279N|TPO_ENST00000382198.1_Missense_Mutation_p.D279N|TPO_ENST00000337415.3_Missense_Mutation_p.D452N|TPO_ENST00000382201.3_Missense_Mutation_p.D452N|TPO_ENST00000329066.4_Missense_Mutation_p.D452N|TPO_ENST00000346956.3_Missense_Mutation_p.D452N	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	452					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CACCCTGAGGGATTACATCCC	0.577000													13	24					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46946496	46946496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46946496G>A	ENST00000429979.1	-	3	719	c.115C>T	c.(115-117)Cct>Tct	p.P39S	KIAA0226L_ENST00000378784.4_Intron|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.P39S|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.P39S|KIAA0226L_ENST00000534925.1_Intron|KIAA0226L_ENST00000409879.2_Intron|KIAA0226L_ENST00000480935.1_Intron|KIAA0226L_ENST00000322896.6_Intron|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.P39S|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.P39S	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	39										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						AATTGGCAAGGAGGATGGTCA	0.542000													8	30					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241964441	241964441	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:241964441G>A	ENST00000366552.2	+	27	3377	c.3170G>A	c.(3169-3171)cGa>cAa	p.R1057Q	WDR64_ENST00000437684.2_Missense_Mutation_p.R890Q	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	1057										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CAGGCACCACGAAGAAGAAGT	0.373000													25	74					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124201687	124201687	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124201687C>T	ENST00000360013.3	+	28	4345	c.4218C>T	c.(4216-4218)tcC>tcT	p.S1406S	KALRN_ENST00000240874.3_Silent_p.S1406S|KALRN_ENST00000460856.1_Silent_p.S1397S	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1406	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGGCCAACTCCATCTCTTCCT	0.512000													16	129					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44637951	44637951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:44637951G>A	ENST00000332990.5	-	3	356	c.340C>T	c.(340-342)Cct>Tct	p.P114S		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	114						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						TCTAGCAAAGGAGGCTCTTCA	0.388000													4	39					0	0	1	0	0
YAE1D1	57002	broad.mit.edu	37	7	39610212	39610212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:39610212C>T	ENST00000432096.2	+	2	250	c.237C>T	c.(235-237)ctC>ctT	p.L79L	YAE1D1_ENST00000223273.2_Silent_p.L79L|YAE1D1_ENST00000448268.1_Silent_p.L79L			Q9NRH1	CG036_HUMAN	Yae1 domain containing 1	79																	ATGGACGACTCCGAGGAACAT	0.348000													26	89					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20552473	20552473	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20552473C>T	ENST00000504154.1	+	25	2765	c.2513C>T	c.(2512-2514)tCt>tTt	p.S838F	SLIT2_ENST00000273739.5_Missense_Mutation_p.S842F|SLIT2_ENST00000503823.1_Missense_Mutation_p.S830F|SLIT2_ENST00000509394.2_3'UTR|SLIT2_ENST00000503837.1_Missense_Mutation_p.S834F	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	838					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AATGACATTTCTGTTGTGCCT	0.343000													21	67					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106554835	106554835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:106554835G>A	ENST00000369096.4	+	7	2186	c.1952G>A	c.(1951-1953)cGa>cAa	p.R651Q	PRDM1_ENST00000369091.2_Missense_Mutation_p.R615Q|PRDM1_ENST00000369089.3_Missense_Mutation_p.R517Q	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	651					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACCCACCTGCGACTCCATTCT	0.547000			"""D, N, Mis, F, S"""		DLBCL								40	55					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171911	68171911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:68171911C>T	ENST00000243457.3	+	2	1114	c.731C>T	c.(730-732)cCt>cTt	p.P244L	KCNJ2_ENST00000535240.1_Missense_Mutation_p.P244L	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	244					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					GAGTATATCCCTCTGGATCAA	0.443000													24	70					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66083207	66083207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66083207G>A	ENST00000311330.3	-	1	1308	c.1292C>T	c.(1291-1293)cCc>cTc	p.P431L	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	431	Pro-rich.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	ACTGAGCGGGGGTGGCCAGGT	0.657000													58	93					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23731354	23731354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23731354G>A	ENST00000304749.2	-	1	220	c.150C>T	c.(148-150)ttC>ttT	p.F50F	CST1_ENST00000398402.1_Silent_p.F50F	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	50						extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					CGCTGATGGCGAAGTGAAGGG	0.572000													11	76					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3265441	3265441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3265441C>T	ENST00000520002.1	-	15	2609	c.2054G>A	c.(2053-2055)gGg>gAg	p.G685E	CSMD1_ENST00000542608.1_Missense_Mutation_p.G684E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G685E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G685E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G684E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G685E|CSMD1_ENST00000539096.1_Missense_Mutation_p.G684E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	685	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GATGTTGAACCCTCTGCCAGT	0.448000													5	11					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22676877	22676877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:22676877G>A	ENST00000376603.2	+	6	1174	c.1032G>A	c.(1030-1032)aaG>aaA	p.K344K	SPAG6_ENST00000376624.3_Silent_p.K268K|SPAG6_ENST00000538630.1_Silent_p.K243K|SPAG6_ENST00000313311.6_Silent_p.K268K|SPAG6_ENST00000376601.1_Intron|RP11-301N24.3_ENST00000422675.1_RNA			O75602	SPAG6_HUMAN	sperm associated antigen 6	268					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						AATACGTGAAGAAAAATGCTT	0.358000													19	40					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701182	143701182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143701182C>T	ENST00000408922.2	+	1	161	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TTCTGATATTCCTTGTGGCCT	0.488000													8	49					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139158244	139158244	+	Silent	SNP	G	G	A	rs148245905		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139158244G>A	ENST00000395297.1	-	15	3668	c.3498C>T	c.(3496-3498)ctC>ctT	p.L1166L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1166								p.L1166L(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTCCTCCAGGGAGCCCCAGTT	0.438000										HNSCC(54;0.14)			33	76					0	0	1	0	0
FAM47E-STBD1	100631383	broad.mit.edu	37	4	77227995	77227995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77227995G>A	ENST00000237642.6	+	1	817	c.73G>A	c.(73-75)Ggc>Agc	p.G25S	FAM47E_ENST00000515604.1_Intron|FAM47E-STBD1_ENST00000539752.1_Intron	NM_003943.4	NP_003934.1																					GCTGCTGCGGGGCGGCCCTGG	0.697000											OREG0016232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	45					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886858	123886858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123886858G>A	ENST00000320891.4	+	1	577	c.577G>A	c.(577-579)Gcc>Acc	p.A193T		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A193T(1)		NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AGACACCTCAGCCAACGTGAT	0.527000													93	147					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104061975	104061975	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104061975G>A	ENST00000265148.3	-	36	5839	c.5750C>T	c.(5749-5751)gCt>gTt	p.A1917V	CENPE_ENST00000380026.3_Missense_Mutation_p.A1892V	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1917					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		ACTCACTCTAGCTTTGGTTTC	0.393000													24	40					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63064844	63064844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63064844C>T	ENST00000544661.1	+	4	539	c.111C>T	c.(109-111)ttC>ttT	p.F37F	SLC22A10_ENST00000526800.1_Intron|SLC22A10_ENST00000525620.1_3'UTR|SLC22A10_ENST00000535888.1_5'UTR|SLC22A10_ENST00000332793.6_Silent_p.F192F			Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	192						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GCGCTGCCTTCGCTCCCACCT	0.428000													33	136					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84733647	84733647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:84733647G>A	ENST00000372142.2	+	8	999	c.725G>A	c.(724-726)gGa>gAa	p.G242E	NRG3_ENST00000404547.1_Missense_Mutation_p.G463E|NRG3_ENST00000545131.1_Missense_Mutation_p.G113E|NRG3_ENST00000372141.2_Missense_Mutation_p.G463E|NRG3_ENST00000556918.1_Missense_Mutation_p.G293E|NRG3_ENST00000537893.1_Missense_Mutation_p.G113E|NRG3_ENST00000404576.2_Missense_Mutation_p.G267E	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	463	Ser/Thr-rich.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		CCTGACAGAGGAAGCCAGTCT	0.527000													5	59					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46976939	46976939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46976939G>A	ENST00000371253.2	-	11	2447	c.2232C>T	c.(2230-2232)ctC>ctT	p.L744L	GPR110_ENST00000283297.5_Silent_p.L547L|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	744					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CAAAAGCCAGGAGTGGTTTGC	0.473000													20	68					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30365431	30365431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30365431C>T	ENST00000340513.4	+	9	1400	c.872C>T	c.(871-873)cCt>cTt	p.P291L	TPX2_ENST00000300403.6_Missense_Mutation_p.P291L			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	291					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			CGAAAGCATCCTTCATCTCCT	0.363000													36	67					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6175052	6175052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6175052G>A	ENST00000264870.3	-	12	1773	c.1508C>T	c.(1507-1509)gCt>gTt	p.A503V		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	503					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GGGCTTTTTAGCTCCGTACAT	0.463000													16	54					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24239784	24239784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:24239784C>T	ENST00000338315.4	+	4	417	c.417C>T	c.(415-417)agC>agT	p.S139S	MFSD2B_ENST00000406420.3_Silent_p.S139S			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	139					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						CCTTCACCAGCCTGCGAGGCC	0.662000													6	81					0	0	1	0	0
SERPINI1	5274	broad.mit.edu	37	3	167525098	167525098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167525098C>T	ENST00000295777.5	+	6	1379	c.948C>T	c.(946-948)ttC>ttT	p.F316F	SERPINI1_ENST00000488374.1_3'UTR|SERPINI1_ENST00000446050.2_Silent_p.F316F	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	316					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						CTGAAATTTTCATCAAAGATG	0.294000													15	100					0	0	1	0	0
DNALI1	7802	broad.mit.edu	37	1	38027255	38027255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38027255G>A	ENST00000296218.7	+	4	571	c.561G>A	c.(559-561)caG>caA	p.Q187Q	DNALI1_ENST00000541606.1_Silent_p.Q39Q|DNALI1_ENST00000497858.1_3'UTR	NM_003462.3	NP_003453.2	O14645	IDLC_HUMAN	dynein, axonemal, light intermediate chain 1	165					cellular component movement|single fertilization	axonemal dynein complex	microtubule motor activity			breast(1)|kidney(1)|large_intestine(2)|ovary(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTGCCTACCAGACCCTGTACG	0.597000											OREG0013380	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	33					0	0	1	0	0
CMBL	134147	broad.mit.edu	37	5	10290816	10290816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:10290816C>T	ENST00000296658.3	-	2	479	c.59G>A	c.(58-60)gGg>gAg	p.G20E	CMBL_ENST00000510532.1_5'UTR	NM_138809.3	NP_620164.1	Q96DG6	CMBL_HUMAN	carboxymethylenebutenolidase homolog (Pseudomonas)	20						cytosol	hydrolase activity|protein binding			endometrium(1)|large_intestine(1)|lung(9)|skin(1)|stomach(1)	13						ACGGCCTAGCCCTCCATACTC	0.473000													10	151					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53997401	53997401	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:53997401G>A	ENST00000396328.1	-	11	1371	c.1132C>T	c.(1132-1134)Caa>Taa	p.Q378*	WDR72_ENST00000360509.5_Nonsense_Mutation_p.Q378*|WDR72_ENST00000559418.1_Nonsense_Mutation_p.Q388*|WDR72_ENST00000557913.1_Nonsense_Mutation_p.Q375*	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	378										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		AAATTATCTTGAAGAGTCCAG	0.353000													23	72					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468244	56468244	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56468244G>A	ENST00000312153.1	+	1	381	c.381G>A	c.(379-381)aaG>aaA	p.K127K		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						CCATCTCCAAGCCCCTGCTTT	0.522000													33	169					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16870169	16870169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16870169C>T	ENST00000524140.2	+	7	2321	c.1903C>T	c.(1903-1905)Cgt>Tgt	p.R635C	NWD1_ENST00000523826.1_Missense_Mutation_p.R429C|NWD1_ENST00000379808.3_Missense_Mutation_p.R635C|NWD1_ENST00000552788.1_Missense_Mutation_p.R635C|NWD1_ENST00000339803.6_Missense_Mutation_p.R500C|NWD1_ENST00000549814.1_Missense_Mutation_p.R635C	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	635	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGTGCGGCTTCGTCGGGATCT	0.652000													8	15					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201079390	201079390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201079390C>T	ENST00000362061.3	-	2	386	c.160G>A	c.(160-162)Gag>Aag	p.E54K	CACNA1S_ENST00000367338.3_Missense_Mutation_p.E54K	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	54					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATGATCGTCTCGAAGGGCCTG	0.577000													23	53					0	0	1	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113588364	113588364	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113588364C>T	ENST00000358160.4	+	3	677	c.185C>T	c.(184-186)tCc>tTc	p.S62F	GRAMD1C_ENST00000479212.1_3'UTR|GRAMD1C_ENST00000452134.2_5'UTR	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	62						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						ATTTCAAGTTCCACCTATAAA	0.303000													34	88					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153219	5153219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5153219G>A	ENST00000307388.1	-	1	653	c.654C>T	c.(652-654)acC>acT	p.T218T		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CATAGGACAAGGTTATAAATA	0.423000													36	70					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132623221	132623221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:132623221C>T	ENST00000315480.4	+	7	494	c.336C>T	c.(334-336)tcC>tcT	p.S112S	USP20_ENST00000358355.1_Silent_p.S112S|USP20_ENST00000372429.3_Silent_p.S112S			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	112					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				CACAGGACTCCCCGCCACCCT	0.567000													70	136					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34778553	34778553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34778553C>T	ENST00000338074.2	+	11	1295	c.1134C>T	c.(1132-1134)tcC>tcT	p.S378S	EPB41L1_ENST00000373946.3_Silent_p.S347S|EPB41L1_ENST00000373950.2_Silent_p.S281S|EPB41L1_ENST00000441639.1_Silent_p.S316S|EPB41L1_ENST00000202028.5_Silent_p.S316S|EPB41L1_ENST00000373941.1_Silent_p.S378S	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	378	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					GGCTGGTGTCCCCTGAGCCCC	0.632000													18	44					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073116	17073116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17073116C>T	ENST00000359963.3	-	1	584	c.325G>A	c.(325-327)Gtt>Att	p.V109I		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	109					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GTCAGCAGAACCACGAAGGCT	0.657000													19	64					0	0	1	0	0
FES	2242	broad.mit.edu	37	15	91433170	91433170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91433170G>A	ENST00000328850.3	+	8	1169	c.1027G>A	c.(1027-1029)Gag>Aag	p.E343K	FES_ENST00000450438.2_Missense_Mutation_p.E285K|FES_ENST00000394300.3_Missense_Mutation_p.E285K|FES_ENST00000394302.1_Missense_Mutation_p.E285K|FES_ENST00000414248.2_Missense_Mutation_p.E285K|FES_ENST00000448367.1_3'UTR|FES_ENST00000444422.2_Missense_Mutation_p.E343K	NM_002005.3	NP_001996.1	P07332	FES_HUMAN	feline sarcoma oncogene	343					axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GAATGAAGAGGAGAACACCCA	0.647000													25	98					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32975413	32975413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32975413C>T	ENST00000340811.4	-	8	1935	c.1827G>A	c.(1825-1827)agG>agA	p.R609R	PKP2_ENST00000070846.6_Silent_p.R653R	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	653					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTTTTACTTTCCTGCTTCGAC	0.378000													15	68					0	0	1	0	0
SLAMF1	6504	broad.mit.edu	37	1	160607071	160607071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160607071C>T	ENST00000302035.6	-	2	674	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	SLAMF1_ENST00000355199.3_Missense_Mutation_p.E109K|SLAMF1_ENST00000235739.5_Missense_Mutation_p.E109K|SLAMF1_ENST00000494463.1_5'UTR|SLAMF1_ENST00000538290.1_Missense_Mutation_p.E109K	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	109					interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TTCCTGCTTTCCCGTATCCCC	0.468000													36	97					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106124613	106124613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106124613G>A	ENST00000369704.3	+	4	697	c.563G>A	c.(562-564)cGa>cAa	p.R188Q	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	188										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GAAACAGAGCGATCAAAAGAG	0.473000													25	47					0	0	1	0	0
UTP11L	51118	broad.mit.edu	37	1	38484756	38484756	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38484756T>A	ENST00000373014.4	+	5	429	c.368T>A	c.(367-369)cTc>cAc	p.L123H	UTP11L_ENST00000537711.1_Missense_Mutation_p.L123H|UTP11L_ENST00000488453.1_3'UTR	NM_016037.3	NP_057121.2	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)	123					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding			NS(1)|cervix(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AAATCAGAGCTCCATCTGCTG	0.363000													25	82					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19506390	19506390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19506390C>T	ENST00000407835.1	+	19	1916	c.1660C>T	c.(1660-1662)Cgg>Tgg	p.R554W	CDC45_ENST00000263201.1_Missense_Mutation_p.R554W|CDC45_ENST00000437685.2_Missense_Mutation_p.R586W|CDC45_ENST00000404724.3_Missense_Mutation_p.R508W			O75419	CDC45_HUMAN	cell division cycle 45	554					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						AGCTGAGGATCGGAGCAAGTT	0.552000													43	138					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20806929	20806929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20806929C>T	ENST00000359062.3	+	15	3014	c.2974C>T	c.(2974-2976)Cgt>Tgt	p.R992C	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	992	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTTCATGGATCGTTCTGCTCC	0.468000													22	64					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39883676	39883676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39883676C>T	ENST00000341184.6	+	2	539	c.324C>T	c.(322-324)ttC>ttT	p.F108F		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	108					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					CCGAGTATTTCGTGCGCACCA	0.706000													7	21					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42122113	42122113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42122113C>T	ENST00000502486.1	-	5	1924	c.1345G>A	c.(1345-1347)Gaa>Aaa	p.E449K	BEND4_ENST00000504360.1_Intron	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	449	BEN.									NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						GGGCGTCTTTCGGGACCTGTC	0.498000													11	22					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614655	247614655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247614655G>A	ENST00000318749.6	-	1	653	c.630C>T	c.(628-630)ttC>ttT	p.F210F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F210F(1)		endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GCACCAACACGAAGAAGGCCA	0.562000													23	48					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123594435	123594435	+	Missense_Mutation	SNP	C	C	T	rs141109529		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123594435C>T	ENST00000340011.5	+	3	1168	c.811C>T	c.(811-813)Cct>Tct	p.P271S	SPAM1_ENST00000460182.1_Missense_Mutation_p.P271S|SPAM1_ENST00000439500.1_Missense_Mutation_p.P271S|SPAM1_ENST00000223028.7_Missense_Mutation_p.P271S|SPAM1_ENST00000402183.2_Missense_Mutation_p.P271S	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	271					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	TCAGCAGTCTCCTGTAGCTGC	0.413000													40	110					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24187498	24187498	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24187498G>A	ENST00000265769.4	+	11	1083	c.972_splice	c.e11-1	p.D325_splice	ADAM28_ENST00000437154.2_Splice_Site_p.D325_splice|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_Splice_Site_p.D72_splice|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_Splice_Site_p.D92_splice|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000518516.1_3'UTR	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	325	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATACCTTTAGGACCACAGCGA	0.408000													25	100					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353848	77353848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77353848C>T	ENST00000282849.5	-	16	2848	c.2430G>A	c.(2428-2430)ggG>ggA	p.G810G		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	810	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AGGGGAACTCCCCAGGCCAGT	0.577000													26	65					0	0	1	0	0
AUH	549	broad.mit.edu	37	9	94123928	94123928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:94123928G>A	ENST00000375731.4	-	1	267	c.244C>T	c.(244-246)Ctg>Ttg	p.L82L	AUH_ENST00000478465.1_5'UTR|AUH_ENST00000422391.2_Silent_p.L82L|AUH_ENST00000303617.5_Silent_p.L82L	NM_001698.2	NP_001689.1	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-CoA hydratase	82					branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						TCCTCCTCCAGGTGCCGCACC	0.716000													3	12					0	0	1	0	0
RDH16	8608	broad.mit.edu	37	12	57348915	57348915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57348915G>A	ENST00000398138.3	-	2	1203	c.347C>T	c.(346-348)tCc>tTc	p.S116F	RDH16_ENST00000360752.4_Intron	NM_003708.3	NP_003699.3	O75452	RDH16_HUMAN	retinol dehydrogenase 16 (all-trans)	116					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)	16						CGTGGGCAAGGAGATGCCAGC	0.552000													18	24					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994216	140994216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140994216G>A	ENST00000285879.4	+	4	1312	c.1026G>A	c.(1024-1026)atG>atA	p.M342I	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	342				MT -> VS (in Ref. 2; AAC24227).			protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AGATTCCTATGACCTCCTCCT	0.463000										HNSCC(15;0.026)			115	94					0	0	1	0	0
CCL8	6355	broad.mit.edu	37	17	32647341	32647341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:32647341C>T	ENST00000394620.1	+	2	596	c.130C>T	c.(130-132)Cct>Tct	p.P44S		NM_005623.2	NP_005614.2	P80075	CCL8_HUMAN	chemokine (C-C motif) ligand 8	44					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity			NS(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Ovarian(249;0.0443)|Breast(31;0.151)				TAGGAAAATTCCTATCCAGAG	0.443000													9	45					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50605650	50605650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50605650C>T	ENST00000444124.2	-	4	543	c.343G>A	c.(343-345)Gag>Aag	p.E115K	DDC_ENST00000431062.1_Missense_Mutation_p.E115K|AC018705.5_ENST00000454521.1_RNA|DDC_ENST00000380984.4_Missense_Mutation_p.E115K|DDC_ENST00000489162.1_5'UTR|DDC_ENST00000357936.5_Missense_Mutation_p.E115K|DDC_ENST00000426377.1_Intron	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	115	2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ATCACAGTCTCCAGCTCTGTG	0.552000													21	47					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112535	57112535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57112535G>A	ENST00000454682.1	-	3	3060	c.2779C>T	c.(2779-2781)Cct>Tct	p.P927S	NACA_ENST00000548563.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						ATTCCTTTAGGGGCTGGAGTT	0.617000			T	BCL6	NHL								15	31					0	0	1	0	0
CD274	29126	broad.mit.edu	37	9	5457416	5457416	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:5457416C>T	ENST00000381577.3	+	3	476	c.390C>T	c.(388-390)gtC>gtT	p.V130V	CD274_ENST00000498261.1_3'UTR|CD274_ENST00000381573.4_Intron	NM_014143.3	NP_054862.1	Q9NZQ7	PD1L1_HUMAN	CD274 molecule	130					cell proliferation|cell surface receptor linked signaling pathway|immune response|T cell costimulation	endomembrane system|integral to membrane	receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000742)|Lung(218;0.111)		CTGTGAAAGTCAATGGTAAGA	0.393000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								4	31					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6599215	6599215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6599215C>T	ENST00000433363.2	-	7	1118	c.885G>A	c.(883-885)gaG>gaA	p.E295E	SLC13A5_ENST00000293800.6_Silent_p.E278E|SLC13A5_ENST00000381074.4_Silent_p.E252E|SLC13A5_ENST00000573648.1_Silent_p.E295E	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	295						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						GGGCAGCCTTCTCGTTTTTCT	0.562000													60	94					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28913995	28913995	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28913995C>T	ENST00000257192.4	+	8	1047	c.835C>T	c.(835-837)Caa>Taa	p.Q279*		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	279	Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CATAGAAATTCAAGAAAATAC	0.338000													23	73					0	0	1	0	0
RECQL	5965	broad.mit.edu	37	12	21624011	21624011	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21624011A>G	ENST00000444129.2	-	14	2157	c.1689T>C	c.(1687-1689)gcT>gcC	p.A563A	RECQL_ENST00000421138.2_Silent_p.A563A	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	563					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						TGGTAGCATAAGCTGTAAAAC	0.338000								Other identified genes with known or suspected DNA repair function					32	76					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25451229	25451229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25451229G>A	ENST00000255324.5	+	34	4730	c.4678G>A	c.(4678-4680)Gag>Aag	p.E1560K	RNF17_ENST00000339524.3_Missense_Mutation_p.E570K|RNF17_ENST00000381921.1_Missense_Mutation_p.E1518K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1560					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GGATCTAGGGGAGACAAGAAT	0.463000													43	90					0	0	1	0	0
KLRC4	8302	broad.mit.edu	37	12	10560951	10560951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10560951G>A	ENST00000309384.1	-	3	498	c.317C>T	c.(316-318)tCc>tTc	p.S106F	KLRC4-KLRK1_ENST00000539300.1_Silent_p.F97F	NM_013431.2	NP_038459.1	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C, member 4	106					cellular defense response	integral to membrane	binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	5						TCTATTCAGGGAAAAATTGTT	0.279000													12	29					0	0	1	0	0
ARHGAP44	9912	broad.mit.edu	37	17	12832322	12832322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12832322G>A	ENST00000379672.5	+	7	841	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	ARHGAP44_ENST00000262444.9_Missense_Mutation_p.E181K|ARHGAP44_ENST00000340825.3_Missense_Mutation_p.E181K	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	181	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						TGCCCTCAGGGAAGAAATGGA	0.552000													10	14					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38593037	38593037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38593037G>A	ENST00000413689.1	-	28	5019	c.4826C>T	c.(4825-4827)tCg>tTg	p.S1609L	SCN5A_ENST00000423572.2_Missense_Mutation_p.S1608L|SCN5A_ENST00000425664.1_Missense_Mutation_p.S1591L|SCN5A_ENST00000333535.4_Missense_Mutation_p.S1609L|SCN5A_ENST00000451551.2_Missense_Mutation_p.S1555L|SCN5A_ENST00000455624.2_Missense_Mutation_p.S1576L|SCN5A_ENST00000449557.2_Missense_Mutation_p.S1555L|SCN5A_ENST00000450102.2_Missense_Mutation_p.S1555L|SCN5A_ENST00000443581.1_Missense_Mutation_p.S1608L|SCN5A_ENST00000414099.2_Missense_Mutation_p.S1591L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1609			S -> W (in LQT3).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GATGATGTCCGAGAGCACAGT	0.617000													24	76					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039025	11039025	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039025C>T	ENST00000470054.1	-	0	1178									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACACAACCCTCAATTGTAGGA	0.383000													28	691					0	0	1	0	0
FCHSD1	89848	broad.mit.edu	37	5	141029033	141029033	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141029033G>A	ENST00000435817.2	-	5	354	c.304C>T	c.(304-306)Cag>Tag	p.Q102*	FCHSD1_ENST00000519800.1_Nonsense_Mutation_p.Q100*|FCHSD1_ENST00000522783.1_Nonsense_Mutation_p.Q100*|FCHSD1_ENST00000522126.1_Nonsense_Mutation_p.Q26*	NM_033449.2	NP_258260.1	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	102									FCHSD1/BRAF(2)	central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGACGCCTGGAGTCGGGTT	0.637000													72	119					0	0	1	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249751	119249751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:119249751C>T	ENST00000217999.2	-	1	96	c.22G>A	c.(22-24)Gac>Aac	p.D8N	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	8					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						AACACGGTGTCGTGGACGAGC	0.607000													8	35					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113304061	113304061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113304061C>T	ENST00000264852.4	+	9	1671	c.945C>T	c.(943-945)ttC>ttT	p.F315F	SIDT1_ENST00000393830.3_Silent_p.F315F	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	315						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						TCAGTGTCTTCATCTTCCTGT	0.413000													63	202					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113075226	113075226	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113075226C>T	ENST00000316851.7	+	2	316	c.316_splice	c.e2+1	p.Q106_splice	NCAM1_ENST00000533760.1_5'UTR|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Splice_Site_p.Q115_splice	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	116	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane		p.Q106*(1)|p.Q115*(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GAAGATCTTTCGTAAGAGCCT	0.517000													8	25					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28539966	28539966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28539966C>T	ENST00000452236.2	-	4	4317	c.3700G>A	c.(3700-3702)Gaa>Aaa	p.E1234K		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1234					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ttcaatccttcgtcggtagcc	0.328000													19	50					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228482721	228482721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228482721C>T	ENST00000570156.2	+	48	12997	c.12923C>T	c.(12922-12924)aCc>aTc	p.T4308I	OBSCN_ENST00000366707.4_Missense_Mutation_p.T998I|OBSCN_ENST00000422127.1_Missense_Mutation_p.T3879I|OBSCN_ENST00000284548.11_Missense_Mutation_p.T3879I|OBSCN_ENST00000366709.4_Missense_Mutation_p.T998I|OBSCN_ENST00000359599.6_Missense_Mutation_p.T2726I	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3351	Ig-like 44.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGGAGAGGACCTCGGCCACA	0.582000													35	89					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39563886	39563886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39563886C>T	ENST00000287152.7	-	7	884	c.790G>A	c.(790-792)Ggc>Agc	p.G264S	KIF6_ENST00000373216.3_Missense_Mutation_p.G264S|KIF6_ENST00000373213.4_Missense_Mutation_p.G103S|KIF6_ENST00000373215.3_Missense_Mutation_p.G264S|KIF6_ENST00000538893.1_Missense_Mutation_p.G264S	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	264	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						AGAAGATGGCCCCCTACTCCA	0.448000													17	77					0	0	1	0	0
GZMA	3001	broad.mit.edu	37	5	54405889	54405889	+	Missense_Mutation	SNP	G	G	A	rs147876051	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54405889G>A	ENST00000274306.6	+	5	703	c.668G>A	c.(667-669)cGa>cAa	p.R223Q		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	223	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GGTGTTTTCCGAGGGGTCACT	0.483000													34	75					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71610209	71610209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71610209C>T	ENST00000355962.4	-	2	243	c.110G>A	c.(109-111)aGa>aAa	p.R37K	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	37					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CCTGGCCTTTCTGCCTTTCAT	0.502000													23	55					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60757792	60757792	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60757792G>A	ENST00000303375.5	+	16	2853	c.2451G>A	c.(2449-2451)cgG>cgA	p.R817R		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	817					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						CGGACGTGCGGGAGCCCGACG	0.652000													46	134					0	0	1	0	0
HUNK	30811	broad.mit.edu	37	21	33318442	33318442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:33318442C>T	ENST00000270112.2	+	4	1065	c.705C>T	c.(703-705)ctC>ctT	p.L235L		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	235	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						CTGAACTGCTCGCCAGGAAGA	0.542000													7	84					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54219328	54219328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54219328G>A	ENST00000259782.4	+	9	1240	c.1144G>A	c.(1144-1146)Gaa>Aaa	p.E382K		NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	382					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			GCAAGTCCGTGAAGATTTCTT	0.338000													32	93					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116548684	116548684	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:116548684T>G	ENST00000410059.1	+	18	2039	c.1559T>G	c.(1558-1560)aTg>aGg	p.M520R	DPP10_ENST00000409163.1_Missense_Mutation_p.M470R|DPP10_ENST00000310323.8_Missense_Mutation_p.M513R|DPP10_ENST00000393147.2_Missense_Mutation_p.M524R	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	520					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity	p.M513T(1)		breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AGCAATTCTATGCTGAAGGAA	0.328000													14	48					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28541300	28541300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28541300G>A	ENST00000452236.2	-	4	2983	c.2366C>T	c.(2365-2367)tCa>tTa	p.S789L		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	789					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ttttggttgtgaacttatttc	0.338000													16	63					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32913745	32913745	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32913745C>T	ENST00000544455.1	+	11	5480	c.5253C>T	c.(5251-5253)taC>taT	p.Y1751Y	BRCA2_ENST00000380152.3_Silent_p.Y1751Y	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1751					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GCTATTCCTACCATTCTGATG	0.303000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			25	53					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169529932	169529932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169529932G>A	ENST00000367796.3	-	4	647	c.446C>T	c.(445-447)aCc>aTc	p.T149I	F5_ENST00000546081.1_Missense_Mutation_p.T12I|F5_ENST00000367797.3_Missense_Mutation_p.T149I			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	149	F5/8 type A 1.|Plastocyanin-like 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCATTCATAGGTGTATTCTCG	0.507000													33	124					0	0	1	0	0
ZNF558	148156	broad.mit.edu	37	19	8931968	8931968	+	Silent	SNP	G	G	A	rs143685735	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8931968G>A	ENST00000601372.1	-	7	846	c.135C>T	c.(133-135)ttC>ttT	p.F45F	ZNF558_ENST00000444186.2_5'UTR|ZNF558_ENST00000301475.1_Silent_p.F45F			Q96NG5	ZN558_HUMAN	zinc finger protein 558	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						CCACATCCTCGAAGGTTACCA	0.587000													53	97					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160952867	160952867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160952867C>T	ENST00000447678.1	-	40	6137	c.6017G>A	c.(6016-6018)gGa>gAa	p.G2006E	LPA_ENST00000484276.1_Intron|LPA_ENST00000316300.5_Missense_Mutation_p.G2006E	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4514	Kringle 18.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGAAGTGACTCCTTGTAAAAT	0.463000													33	45					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20150048	20150048	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20150048C>T	ENST00000245957.5	+	13	1405	c.1329C>T	c.(1327-1329)ttC>ttT	p.F443F	C20orf26_ENST00000377306.1_Silent_p.F443F|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000451767.2_Silent_p.F443F|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	443										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TGGTCCCTTTCAACACCTGCA	0.473000													31	92					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152496921	152496921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152496921G>A	ENST00000427231.2	-	61	8835	c.8633C>T	c.(8632-8634)cCc>cTc	p.P2878L	NEB_ENST00000604864.1_Missense_Mutation_p.P2878L|NEB_ENST00000603639.1_Missense_Mutation_p.P2878L|NEB_ENST00000172853.10_Missense_Mutation_p.P2878L|NEB_ENST00000397345.3_Missense_Mutation_p.P2878L|NEB_ENST00000409198.1_Missense_Mutation_p.P2878L	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2878					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCTCTGGTCGGGCAGGCATGT	0.542000													69	221					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141215150	141215150	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141215150C>T	ENST00000389484.3	-	61	10667	c.9696G>A	c.(9694-9696)ggG>ggA	p.G3232G		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3232					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTTGGTTTTCCCATCAGTCC	0.428000										TSP Lung(27;0.18)			57	144					0	0	1	0	0
PRKD2	25865	broad.mit.edu	37	19	47200991	47200991	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47200991A>G	ENST00000433867.1	-	9	1715	c.1239_splice	c.e9+1	p.L413_splice	PRKD2_ENST00000291281.4_Splice_Site_p.L413_splice|PRKD2_ENST00000601806.1_Splice_Site_p.L256_splice|PRKD2_ENST00000595515.1_Splice_Site_p.L413_splice|PRKD2_ENST00000600194.1_Splice_Site_p.L256_splice	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	413	PH.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		gccACTCACCAGCGTGTCCTT	0.662000													37	89					0	0	1	0	0
PIFO	128344	broad.mit.edu	37	1	111889591	111889591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111889591C>T	ENST00000369738.4	+	2	444	c.79C>T	c.(79-81)Cat>Tat	p.H27Y	PIFO_ENST00000369737.4_Missense_Mutation_p.H27Y|PIFO_ENST00000484512.1_3'UTR	NM_181643.4	NP_857594.2			primary cilia formation																		TCCTCACTTCCATCCCCCGAA	0.488000													24	67					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108124224	108124224	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108124224C>T	ENST00000273353.3	-	34	4813	c.4757G>A	c.(4756-4758)aGa>aAa	p.R1586K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1586						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TGAAAGCTTTCTTTCAAGTTC	0.328000													22	26					0	0	1	0	0
MYL12A	10627	broad.mit.edu	37	18	3253251	3253251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3253251G>A	ENST00000217652.3	+	2	401	c.6G>A	c.(4-6)tcG>tcA	p.S2S	MYL12A_ENST00000579226.1_Silent_p.S2S|MYL12A_ENST00000536605.1_Silent_p.S2S|MYL12A_ENST00000580887.1_Silent_p.S8S|MYL12A_ENST00000578611.1_Silent_p.S2S	NM_006471.2	NP_006462.1	P19105	ML12A_HUMAN	myosin, light chain 12A, regulatory, non-sarcomeric	2						myosin complex	calcium ion binding|protein binding			NS(1)|kidney(2)|large_intestine(2)	5						CCACCATGTCGAGCAAAAGAA	0.378000													33	129					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131515789	131515789	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131515789A>G	ENST00000291900.2	-	4	806	c.400T>C	c.(400-402)Ttg>Ctg	p.L134L	ZER1_ENST00000494461.1_5'UTR	NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	134					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						AAGAGGCTCAAGGACACCAGG	0.567000													8	46					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126676290	126676290	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:126676290C>A	ENST00000274473.6	+	5	554	c.287C>A	c.(286-288)cCt>cAt	p.P96H	MEGF10_ENST00000508365.1_Missense_Mutation_p.P96H|MEGF10_ENST00000418761.2_Missense_Mutation_p.P96H|MEGF10_ENST00000503335.2_Missense_Mutation_p.P96H	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	96	EMI.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CAGTGTTGTCCTGGATTTTAT	0.428000													36	73					1.57019e-19	1.57956e-19	1	1	0
RAI2	10742	broad.mit.edu	37	X	17819535	17819535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:17819535C>T	ENST00000545871.1	-	3	1056	c.596G>A	c.(595-597)gGg>gAg	p.G199E	RAI2_ENST00000415486.3_Missense_Mutation_p.G149E|RAI2_ENST00000360011.1_Missense_Mutation_p.G199E|RAI2_ENST00000451717.1_Missense_Mutation_p.G199E|RAI2_ENST00000331511.1_Missense_Mutation_p.G199E	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	199					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					GGGTGGGGGCCCGAGAGTGCC	0.647000													18	20					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130846099	130846099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130846099G>A	ENST00000245255.3	+	16	2195	c.1923G>A	c.(1921-1923)cgG>cgA	p.R641R		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	641	Piwi.|RNA-binding (By similarity).				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CAGCTGGGCGGAGGTCAATCG	0.483000													14	98					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141709478	141709478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141709478G>A	ENST00000389484.3	-	19	3890	c.2919C>T	c.(2917-2919)ttC>ttT	p.F973F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	973	LDL-receptor class A 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTGCATACGAATTGGGTTA	0.418000										TSP Lung(27;0.18)			19	52					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204588011	204588011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204588011G>A	ENST00000367175.1	-	1	3322	c.1110C>T	c.(1108-1110)ccC>ccT	p.P370P	LRRN2_ENST00000367176.3_Silent_p.P370P|LRRN2_ENST00000367177.3_Silent_p.P370P			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	370	LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			CACAGCGGATGGGGTTGCCGT	0.637000													25	69					0	0	1	0	0
NAT16	375607	broad.mit.edu	37	7	100815389	100815389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100815389C>T	ENST00000300303.2	-	4	1319	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	NAT16_ENST00000455377.1_Missense_Mutation_p.E361K	NM_198571.2	NP_940973.2	Q8N8M0	CG052_HUMAN	N-acetyltransferase 16 (GCN5-related, putative)	361							N-acetyltransferase activity										AGGTACTGTTCAGTATAACCC	0.622000													17	51					0	0	1	0	0
MYOZ2	51778	broad.mit.edu	37	4	120079232	120079232	+	Missense_Mutation	SNP	C	C	T	rs138061447		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:120079232C>T	ENST00000307128.5	+	4	515	c.302C>T	c.(301-303)tCg>tTg	p.S101L		NM_016599.4	NP_057683.1	Q9NPC6	MYOZ2_HUMAN	myozenin 2	101							protein phosphatase 2B binding			endometrium(1)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						GAAGGTGGTTCGCAGCAAGCC	0.463000													53	118					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107743504	107743504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107743504G>A	ENST00000388781.3	-	10	1248	c.1165C>T	c.(1165-1167)Ccc>Tcc	p.P389S	LAMB4_ENST00000205386.4_Missense_Mutation_p.P389S|LAMB4_ENST00000414450.2_Missense_Mutation_p.P389S|LAMB4_ENST00000388780.3_Missense_Mutation_p.P389S	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	389	Laminin EGF-like 2.				cell adhesion	basement membrane		p.P389S(2)		NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CACGCGTAGGGATCTGAGATG	0.597000													9	24					0	0	1	0	0
IL5	3567	broad.mit.edu	37	5	131878811	131878811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131878811C>T	ENST00000231454.1	-	2	195	c.152G>A	c.(151-153)aGg>aAg	p.R51K		NM_000879.2	NP_000870.1	P05113	IL5_HUMAN	interleukin 5 (colony-stimulating factor, eosinophil)	51					immune response|inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of podosome assembly	extracellular space	cytokine activity|growth factor activity|interleukin-5 receptor binding			endometrium(1)|large_intestine(1)|stomach(1)|upper_aerodigestive_tract(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Pranlukast(DB01411)	AACAGGAATCCTCAGAGTCTG	0.328000													11	46					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89985834	89985834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89985834G>A	ENST00000405460.2	+	30	6743	c.6647G>A	c.(6646-6648)gGg>gAg	p.G2216E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2216					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCCAGACTAGGGGCTTTAACA	0.393000													6	7					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29294506	29294506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29294506C>T	ENST00000331664.5	-	1	2621	c.2622G>A	c.(2620-2622)agG>agA	p.R874R		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	874					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CCCATGTTCTCCTGGTGGGGC	0.627000													23	66					0	0	1	0	0
IGLV7-43	28776	broad.mit.edu	37	22	22749636	22749636	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22749636C>T	ENST00000390298.2	+	0	194																											TGGTTACTATCCAAACTGGTT	0.557000													13	51					0	0	1	0	0
GGT5	2687	broad.mit.edu	37	22	24621549	24621549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24621549C>T	ENST00000327365.4	-	9	1717	c.1301G>A	c.(1300-1302)cGa>cAa	p.R434Q	GGT5_ENST00000263112.7_Missense_Mutation_p.R402Q|GGT5_ENST00000398292.3_Missense_Mutation_p.R434Q|GGT5_ENST00000418439.2_Missense_Mutation_p.R357Q	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	434					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						CCGGGGGCATCGCTCGCATAA	0.647000													8	33					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42678454	42678454	+	Missense_Mutation	SNP	G	G	A	rs35855730		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42678454G>A	ENST00000397163.3	+	3	688	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K	CAPN3_ENST00000349748.3_Missense_Mutation_p.E157K|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000318023.7_Missense_Mutation_p.E157K|CAPN3_ENST00000357568.3_Missense_Mutation_p.E157K|CAPN3_ENST00000356316.3_Missense_Mutation_p.E70K	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	157	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		AAGTTTCATCGAAAACTACGC	0.552000											OREG0023085	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	120					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39265901	39265901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39265901C>T	ENST00000280481.7	+	1	4636	c.4420C>T	c.(4420-4422)Cag>Tag	p.Q1474*		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1474					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ATGCACGGATCAGCCTGGTGT	0.468000													21	62					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219249889	219249889	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219249889G>A	ENST00000233202.6	+	4	633	c.293G>A	c.(292-294)tGg>tAg	p.W98*	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	98					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGCTGCTCTGGGCCACCGTG	0.622000													9	91					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	117072882	117072882	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117072882C>T	ENST00000356083.3	+	61	5881	c.5490C>T	c.(5488-5490)ccC>ccT	p.P1830P		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1830	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CCCAAGACCCCCAACAGCTGC	0.557000													10	77					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78471031	78471031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78471031C>T	ENST00000258873.4	-	11	1832	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K	ACSBG1_ENST00000560817.1_Missense_Mutation_p.E301K|ACSBG1_ENST00000541759.1_Missense_Mutation_p.E301K	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	543					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						AGCCAGCCTTCCTCGTCGATG	0.627000													6	41					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151105854	151105854	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151105854G>A	ENST00000341697.3	-	19	3590	c.1899C>T	c.(1897-1899)caC>caT	p.H633H				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	633						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCGACGTCGGTGGGCGCGGC	0.726000													7	15					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47241496	47241496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47241496C>T	ENST00000300404.2	+	8	1052	c.993C>T	c.(991-993)ctC>ctT	p.L331L	B4GALNT2_ENST00000393354.2_Silent_p.L271L|B4GALNT2_ENST00000504681.1_Silent_p.L245L	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	331					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			AGACTTTCCTCCGCCCCCACA	0.507000													43	189					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62291316	62291316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62291316G>A	ENST00000258991.3	-	2	346	c.262C>T	c.(262-264)Cct>Tct	p.P88S	TEX2_ENST00000584379.1_Missense_Mutation_p.P88S|TEX2_ENST00000583097.1_Missense_Mutation_p.P88S			Q8IWB9	TEX2_HUMAN	testis expressed 2	88					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		GAGGCAGCAGGGCCGGCGGGG	0.582000													82	209					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42989105	42989105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42989105C>T	ENST00000253408.5	-	5	906	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K	GFAP_ENST00000435360.2_Missense_Mutation_p.E281K|GFAP_ENST00000586793.1_Missense_Mutation_p.E281K|GFAP_ENST00000588735.1_Intron	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	281	Coil 2B.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				TCGTTGGCTTCGTGCTTGGCC	0.682000													19	29					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17197380	17197380	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:17197380G>A	ENST00000285681.2	+	12	1673	c.1304_splice	c.e12+1	p.R435_splice	USP25_ENST00000400183.2_Splice_Site_p.R435_splice|USP25_ENST00000351097.5_Intron|USP25_ENST00000285679.6_Splice_Site_p.R435_splice			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	435					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AGGCTAGAAAGGTATTTTAAC	0.294000													7	51					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16895655	16895655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16895655G>A	ENST00000430580.2	-	23	3414	c.2527C>T	c.(2527-2529)Cct>Tct	p.P843S	NBPF1_ENST00000287968.8_3'UTR|NBPF1_ENST00000432949.1_Intron|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	843	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AACATTTCAGGAGGAATTGAG	0.512000													40	661					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20782849	20782849	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20782849C>T	ENST00000359062.3	+	6	1588	c.1548C>T	c.(1546-1548)ctC>ctT	p.L516L	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	516					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CAGGTGCCCTCGCTAAAATTT	0.438000													33	85					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11007806	11007806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11007806G>A	ENST00000377004.4	-	12	2385	c.2386C>T	c.(2386-2388)Ccc>Tcc	p.P796S	C1orf127_ENST00000377008.4_Missense_Mutation_p.P629S	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	647										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GCCAAGGTGGGCTCTGTCAGC	0.632000													7	17					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115529650	115529650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115529650C>T	ENST00000361048.1	+	7	870	c.543C>T	c.(541-543)ctC>ctT	p.L181L	PLEKHS1_ENST00000369312.4_Silent_p.L93L|PLEKHS1_ENST00000369310.3_Silent_p.L175L	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		GAAATGGTCTCCAAGACAAGG	0.473000													42	101					0	0	1	0	0
TM6SF1	53346	broad.mit.edu	37	15	83793490	83793490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83793490C>T	ENST00000322019.9	+	7	944	c.670C>T	c.(670-672)Ctc>Ttc	p.L224F	TM6SF1_ENST00000565774.1_Missense_Mutation_p.L224F|TM6SF1_ENST00000379386.4_Missense_Mutation_p.L227F|TM6SF1_ENST00000379390.6_Intron			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	224						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						GGTTGTGTGTCTCCTCCTGGC	0.398000													33	221					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46563104	46563104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46563104G>A	ENST00000242848.4	-	9	1421	c.1073C>T	c.(1072-1074)tCt>tTt	p.S358F	ZC3H13_ENST00000282007.3_Missense_Mutation_p.S358F			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	358	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CCGCTGATAAGATGGTGAAGG	0.448000													13	37					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43972278	43972278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43972278C>T	ENST00000262726.7	-	26	3572	c.3319G>A	c.(3319-3321)Gac>Aac	p.D1107N	EFCAB6_ENST00000396231.2_Missense_Mutation_p.D955N	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TACTGATTGTCCGTTAGTTTG	0.333000													28	70					0	0	1	0	0
SAMD14	201191	broad.mit.edu	37	17	48191778	48191778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48191778C>T	ENST00000503131.1	-	8	1226	c.849G>A	c.(847-849)gaG>gaA	p.E283E	SAMD14_ENST00000330175.4_Intron	NM_174920.3	NP_777580.1	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	274										breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	15						TGCTCAGTGCCTCCTGTGCAT	0.577000													11	52					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21789343	21789343	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21789343C>T	ENST00000328843.6	+	54	8773	c.8742C>T	c.(8740-8742)ccC>ccT	p.P2914P	DNAH11_ENST00000409508.3_Silent_p.P2907P			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2914	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGAACATGCCCACTGTGTTCC	0.458000									Kartagener syndrome				11	49					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62659058	62659058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62659058C>T	ENST00000535781.1	+	16	2299	c.2188C>T	c.(2188-2190)Cgt>Tgt	p.R730C	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	770					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GGAAAAGTCTCGTCTGAAGAA	0.607000													58	145					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36488689	36488689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36488689C>T	ENST00000405275.2	+	16	1708	c.1465C>T	c.(1465-1467)Cac>Tac	p.H489Y	CTNNBL1_ENST00000373469.1_Missense_Mutation_p.H264Y|CTNNBL1_ENST00000373473.1_Missense_Mutation_p.H329Y|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.H516Y|CTNNBL1_ENST00000473857.1_3'UTR			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	516					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				CCAGAGGGTTCACCAGATCCT	0.428000													62	129					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142569570	142569570	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142569570G>A	ENST00000359396.3	-	15	2313	c.2068C>T	c.(2068-2070)Cgc>Tgc	p.R690C		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	690					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding	p.R690C(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					GCACTGCTGCGGGAGGTACTT	0.567000													13	54					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7703877	7703877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:7703877G>A	ENST00000340209.4	+	9	1130	c.833G>A	c.(832-834)cGa>cAa	p.R278Q	RBFOX1_ENST00000422070.4_Missense_Mutation_p.R316Q|RBFOX1_ENST00000547338.1_Missense_Mutation_p.R273Q|RBFOX1_ENST00000547372.1_Missense_Mutation_p.R316Q|RBFOX1_ENST00000355637.4_Missense_Mutation_p.R293Q|RBFOX1_ENST00000553186.1_Missense_Mutation_p.R246Q|RBFOX1_ENST00000436368.2_Missense_Mutation_p.R293Q|RBFOX1_ENST00000535565.2_Missense_Mutation_p.R230Q|RBFOX1_ENST00000311745.5_Missense_Mutation_p.R293Q|RBFOX1_ENST00000552089.1_Missense_Mutation_p.R290Q|RBFOX1_ENST00000550418.1_Missense_Mutation_p.R273Q			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	273					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						GCGCACCTGCGAGGCCGCGGT	0.731000													19	25					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505165	37505165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37505165G>A	ENST00000374660.1	+	38	3214	c.3115G>A	c.(3115-3117)Gaa>Aaa	p.E1039K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E920K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E920K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1042						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AAGAGCAAGGGAACTTCAAAA	0.323000													21	69					0	0	1	0	0
ADH1A	124	broad.mit.edu	37	4	100205629	100205629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100205629G>A	ENST00000209668.2	-	5	607	c.494C>T	c.(493-495)tCg>tTg	p.S165L	RP11-696N14.1_ENST00000500358.2_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	165					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CTCTAGAGGCGAGGCTGCATC	0.478000													25	74					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18022300	18022300	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18022300C>T	ENST00000205890.5	+	2	524	c.186C>T	c.(184-186)ggC>ggT	p.G62G		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	62	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCTTCTGGGGCCTCCACACCG	0.632000													8	13					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104510873	104510873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104510873C>T	ENST00000304883.2	-	5	1504	c.1364G>A	c.(1363-1365)aGc>aAc	p.S455N	RP11-297P16.3_ENST00000502936.1_RNA|RP11-297P16.3_ENST00000512401.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	455						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		ATAGGGTGAGCTTATGAAACT	0.468000													47	135					0	0	1	0	0
CHRNA3	1136	broad.mit.edu	37	15	78894012	78894012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78894012G>A	ENST00000326828.5	-	5	1356	c.972C>T	c.(970-972)ttC>ttT	p.F324F	CHRNA3_ENST00000348639.3_Silent_p.F324F	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	324					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CGTTGAGCACGAAGACGGTGA	0.522000													79	114					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140186830	140186830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140186830C>T	ENST00000530339.1	+	1	58	c.58C>T	c.(58-60)Ctc>Ttc	p.L20F	PCDHA4_ENST00000512229.2_Missense_Mutation_p.L20F|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.L20F|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTACTTCTTCTCCTCGCAGC	0.567000													53	125					0	0	1	0	0
IGKV1D-43	28891	broad.mit.edu	37	2	90249169	90249169	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90249169C>A	ENST00000468879.1	+	0	306																											GACAGAGTCACCATCACTTGC	0.473000													45	188					4.75955e-12	4.78084e-12	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105414114	105414114	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105414114C>T	ENST00000333244.5	-	7	7793	c.7674G>A	c.(7672-7674)gaG>gaA	p.E2558E	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2558						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCCGGCTCCCTCCGGCACAG	0.627000													93	198					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248486954	248486954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248486954C>T	ENST00000317965.2	-	1	945	c.917G>A	c.(916-918)gGa>gAa	p.G306E		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTGCCCTTTCCTAAGATTTT	0.388000													13	61					0	0	1	0	0
TMEM259	91304	broad.mit.edu	37	19	1010531	1010531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1010531G>A	ENST00000356663.3	-	11	1802	c.1681C>T	c.(1681-1683)Ctc>Ttc	p.L561F	TMEM259_ENST00000333175.5_3'UTR	NM_001033026.1	NP_001028198.1			transmembrane protein 259																		CGCTCCAGGAGGGAGGCGCTC	0.701000													2	1					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30740440	30740440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30740440C>T	ENST00000262518.4	+	26	6197	c.5812C>T	c.(5812-5814)Cct>Tct	p.P1938S	SRCAP_ENST00000344771.4_Missense_Mutation_p.P1780S|SRCAP_ENST00000395059.2_Missense_Mutation_p.P1876S	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1938					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCCCATCGGCCCTCGTTCTCC	0.597000													28	67					0	0	1	0	0
PTK6	5753	broad.mit.edu	37	20	62165016	62165016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62165016C>T	ENST00000217185.2	-	4	585	c.558G>A	c.(556-558)agG>agA	p.R186R	PTK6_ENST00000542869.1_Silent_p.R85R	NM_005975.3	NP_005966.1	Q13882	PTK6_HUMAN	protein tyrosine kinase 6	186						cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(3)|kidney(1)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	15	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CCTCCCTCGGCCTCTCCCAGT	0.632000													42	85					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345295	20345295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20345295G>A	ENST00000298642.2	+	1	905	c.869G>A	c.(868-870)aGg>aAg	p.R290K		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TATACTTTGAGGAATCAAGAA	0.358000													20	60					0	0	1	0	0
GABBR2	9568	broad.mit.edu	37	9	101052900	101052900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101052900G>A	ENST00000259455.2	-	19	3251	c.2792C>T	c.(2791-2793)cCa>cTa	p.P931L		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	931					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GAAGGAGGGTGGCACATGTCT	0.692000													7	8					0	0	1	0	0
ZNF660	285349	broad.mit.edu	37	3	44635928	44635928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44635928G>A	ENST00000322734.2	+	3	576	c.243G>A	c.(241-243)aaG>aaA	p.K81K	RP11-944L7.4_ENST00000457331.1_RNA	NM_173658.2	NP_775929.2	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		ATAAGTGTAAGGAGTGTGGAA	0.448000													24	80					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96466679	96466679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96466679C>T	ENST00000285979.6	+	5	980	c.781C>T	c.(781-783)Cgg>Tgg	p.R261W	CYP2C18_ENST00000339022.5_Intron|CYP2C19_ENST00000464755.1_3'UTR	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GAACAGTGCTCGGGACTTTAT	0.328000													31	69					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14607558	14607558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14607558G>A	ENST00000274217.3	+	6	738	c.618G>A	c.(616-618)ttG>ttA	p.L206L		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	206										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					TGGAATTATTGAAAACACAGG	0.393000													24	62					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7976593	7976593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7976593C>T	ENST00000319144.4	-	14	2059	c.1799G>A	c.(1798-1800)cGg>cAg	p.R600Q	ALOX12B_ENST00000577351.1_5'UTR	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	600	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						CGGTGGATTCCGCATGGACGC	0.587000										Multiple Myeloma(8;0.094)			89	129					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23815352	23815352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:23815352C>T	ENST00000264867.2	-	8	1873	c.1754G>A	c.(1753-1755)aGg>aAg	p.R585K	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	585	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TGATCTTGACCTGGAATATGG	0.428000													13	51					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110791056	110791056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110791056C>T	ENST00000327908.3	+	4	1366	c.602C>T	c.(601-603)tCa>tTa	p.S201L	LRIT3_ENST00000594814.1_Missense_Mutation_p.S384L|LRIT3_ENST00000409621.2_Missense_Mutation_p.S201L|LRIT3_ENST00000379920.3_Missense_Mutation_p.S339L			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	339	LRRCT.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		AGCGCATCATCATATCTTTGG	0.468000													56	133					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532013	84532013	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84532013C>T	ENST00000527857.1	+	0	2035					NR_026851.1																						GAAAGTCTTTCAAGGTCCATG	0.463000													12	56					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177632728	177632728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:177632728C>T	ENST00000280193.2	-	4	1044	c.629G>A	c.(628-630)cGa>cAa	p.R210Q	VEGFC_ENST00000507638.1_5'UTR	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	210					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		AGACATGCATCGGCAGGAAGT	0.393000													10	130					0	0	1	0	0
KY	339855	broad.mit.edu	37	3	134366313	134366313	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134366313G>A	ENST00000508956.1	-	2	220	c.163C>T	c.(163-165)Cga>Tga	p.R55*	KY_ENST00000423778.2_Nonsense_Mutation_p.R55*|KY_ENST00000503669.1_Nonsense_Mutation_p.R55*			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	55						cytoskeleton|Z disc	peptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						TGCCATCTTCGGACTCCATTT	0.383000													12	16					0	0	1	0	0
REST	5978	broad.mit.edu	37	4	57796460	57796460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:57796460C>T	ENST00000309042.7	+	4	1750	c.1436C>T	c.(1435-1437)cCt>cTt	p.P479L		NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	479	Lys-rich.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					GAGAAAAAGCCTTCTAATAAT	0.373000													4	52					0	0	1	0	0
OBP2A	29991	broad.mit.edu	37	9	138438674	138438674	+	Silent	SNP	G	G	A	rs142617413	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138438674G>A	ENST00000539850.1	+	2	149	c.123G>A	c.(121-123)ccG>ccA	p.P41P	OBP2A_ENST00000340780.3_Silent_p.P41P|OBP2A_ENST00000342114.4_Intron|OBP2A_ENST00000371776.1_Silent_p.P41P			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	41					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		AGGACTTTCCGGAGGACAGGA	0.602000													9	19					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1940297	1940297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1940297C>T	ENST00000543818.1	+	4	1106	c.264C>T	c.(262-264)ttC>ttT	p.F88F	CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000588077.1_Intron|LRTM2_ENST00000543730.1_Intron|LRTM2_ENST00000299194.1_Silent_p.F88F|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000382722.5_Intron|LRTM2_ENST00000535041.1_Silent_p.F88F	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	88						integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GCTGGGCTTTCGCCAACCTCT	0.622000													7	125					0	0	1	0	0
PLA2G2D	26279	broad.mit.edu	37	1	20440676	20440676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20440676C>T	ENST00000375105.3	-	4	427	c.369G>A	c.(367-369)ctG>ctA	p.L123L		NM_012400.2	NP_036532.1	Q9UNK4	PA2GD_HUMAN	phospholipase A2, group IID	123					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(1)|lung(2)	3		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000798)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGTAGGTGTCCAGGTTGCGCT	0.622000										Multiple Myeloma(11;0.12)			16	51					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204946817	204946817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204946817G>A	ENST00000367172.4	+	17	2168	c.1840G>A	c.(1840-1842)Gcc>Acc	p.A614T	NFASC_ENST00000513543.1_Intron|NFASC_ENST00000338586.6_Missense_Mutation_p.A614T|NFASC_ENST00000367169.4_Missense_Mutation_p.A614T|NFASC_ENST00000360049.4_Intron|NFASC_ENST00000367171.4_Intron|NFASC_ENST00000401399.1_Missense_Mutation_p.A614T|NFASC_ENST00000539706.1_Intron|NFASC_ENST00000367170.4_Missense_Mutation_p.A614T|NFASC_ENST00000339876.6_Missense_Mutation_p.A614T|NFASC_ENST00000404907.1_Intron|NFASC_ENST00000404076.1_Intron|NFASC_ENST00000338515.6_Missense_Mutation_p.A614T			O94856	NFASC_HUMAN	neurofascin	614					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGCTGATCAGGCCACTCCAAC	0.537000													11	34					0	0	1	0	0
LPAL2	80350	broad.mit.edu	37	6	160905242	160905242	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160905242G>A	ENST00000335388.5	-	0	885					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GCCTTCCACAGGATCTGGATT	0.512000													33	43					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10910355	10910355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10910355G>A	ENST00000298232.7	-	21	1714	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.F429F|TPTE_ENST00000361285.4_Silent_p.F467F	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	467	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAGACCGTCGAATACATCAA	0.338000													19	132					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52539139	52539139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52539139G>A	ENST00000242839.4	-	5	1894	c.1738C>T	c.(1738-1740)Cac>Tac	p.H580Y	ATP7B_ENST00000542656.1_Intron|ATP7B_ENST00000400366.3_Missense_Mutation_p.H469Y|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000400370.3_Intron|ATP7B_ENST00000418097.2_Missense_Mutation_p.H580Y|ATP7B_ENST00000448424.2_Missense_Mutation_p.H580Y|ATP7B_ENST00000344297.5_Missense_Mutation_p.H580Y	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	580	HMA 6.				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding	p.H580N(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TCTATGTTGTGGACACAGGAC	0.517000									Wilson disease				32	60					0	0	1	0	0
GSTA3	2940	broad.mit.edu	37	6	52764807	52764807	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52764807T>A	ENST00000211122.3	-	5	404	c.339A>T	c.(337-339)cgA>cgT	p.R113R	GSTA3_ENST00000370968.1_Silent_p.R63R	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	113	GST C-terminal.		R -> Q.	RP -> PA (in Ref. 1; AAA74634).	glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	TTTCCTCAGGTCGACATAAGG	0.393000													103	223					0	0	1	0	0
NUMBL	9253	broad.mit.edu	37	19	41188694	41188694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41188694G>A	ENST00000252891.4	-	5	505	c.338C>T	c.(337-339)tCc>tTc	p.S113F	NUMBL_ENST00000540131.1_Missense_Mutation_p.S72F|NUMBL_ENST00000598779.1_Missense_Mutation_p.S72F	NM_004756.3	NP_004747.1	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	113	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)	16			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			AGACTTCACGGACTTTCGGCC	0.652000													19	60					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810341	106810341	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:106810341G>A	ENST00000526355.1	-	4	1519	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	GUCY1A2_ENST00000282249.2_Nonsense_Mutation_p.R351*|GUCY1A2_ENST00000347596.2_Nonsense_Mutation_p.R351*	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	351					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GTGTCACATCGAAGCTGCTTC	0.473000													21	34					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256171	15256171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15256171C>T	ENST00000378116.4	-	8	1422	c.1416G>A	c.(1414-1416)atG>atA	p.M472I	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	472						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CTTCTCTTTCCATAGATTTTC	0.468000													31	65					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724283	7724283	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:7724283C>T	ENST00000303635.7	+	9	1883	c.1676C>T	c.(1675-1677)tCc>tTc	p.S559F	CAMTA1_ENST00000439411.2_Missense_Mutation_p.S559F	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCAGCCAGCTCCCTCACCCTG	0.662000			T	WWTR1	epitheliod hemangioendothelioma								21	66					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101590503	101590503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101590503C>T	ENST00000370449.4	+	21	2891	c.2778C>T	c.(2776-2778)tcC>tcT	p.S926S		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	926						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ATCTGAAGTCCCTGAGAAACT	0.448000													34	63					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62192546	62192546	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62192546G>A	ENST00000467148.1	-	14	7104	c.7035C>T	c.(7033-7035)gcC>gcT	p.A2345A	HELZ2_ENST00000427522.2_Silent_p.A1776A	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GGCTGGCAGAGGCTGCACAGG	0.602000													12	87					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6312195	6312195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6312195G>A	ENST00000301452.4	-	3	392	c.315C>T	c.(313-315)ccC>ccT	p.P105P		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	105						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						AATAGCAGCGGGGCATCCATA	0.582000													14	47					0	0	1	0	0
DHRS4L1	728635	broad.mit.edu	37	14	24511906	24511906	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24511906C>T	ENST00000558293.1	+	0	437					NR_102693.1				dehydrogenase/reductase (SDR family) member 4 like 1																		GGCTATGAAGCTTCATGGAGT	0.448000													52	203					0	0	1	0	0
ZNF559	84527	broad.mit.edu	37	19	9449179	9449179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9449179C>T	ENST00000587557.1	+	3	553	c.146C>T	c.(145-147)tCt>tTt	p.S49F	ZNF177_ENST00000602856.1_Intron|ZNF559_ENST00000317221.7_5'UTR|ZNF559_ENST00000592504.1_5'UTR|ZNF177_ENST00000446085.4_Intron|ZNF177_ENST00000602738.1_5'UTR|ZNF559_ENST00000603380.1_5'UTR|ZNF559_ENST00000586255.1_Missense_Mutation_p.S13F|ZNF177_ENST00000605471.1_Intron|ZNF559_ENST00000585352.1_5'UTR|ZNF559_ENST00000592896.1_Missense_Mutation_p.S13F|ZNF177_ENST00000541595.2_5'UTR|ZNF559_ENST00000393883.2_5'UTR|ZNF559_ENST00000538743.1_Intron	NM_001202406.1|NM_001202408.1|NM_001202409.1|NM_001202411.1	NP_001189335.1|NP_001189337.1|NP_001189338.1|NP_001189340.1	Q9BR84	ZN559_HUMAN	zinc finger protein 559	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						GATCATCTTTCTCAAGATGTT	0.388000													24	40					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66190294	66190294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66190294C>T	ENST00000311034.2	+	4	756	c.580C>T	c.(580-582)Cct>Tct	p.P194S		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	194					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						TTTCTGTGCCCCTCTGGAGCC	0.622000													20	107					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40713344	40713344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40713344C>T	ENST00000373198.3	-	30	4415	c.4180G>A	c.(4180-4182)Gga>Aga	p.G1394R	PTPRT_ENST00000373187.1_Missense_Mutation_p.G1372R|PTPRT_ENST00000373193.3_Missense_Mutation_p.G1375R|PTPRT_ENST00000373201.1_Missense_Mutation_p.G1362R|PTPRT_ENST00000373184.1_Missense_Mutation_p.G1382R|PTPRT_ENST00000356100.2_Missense_Mutation_p.G1381R|PTPRT_ENST00000373190.1_Missense_Mutation_p.G1371R	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1372	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACAGTACGTCCCTCCCTCCCG	0.607000													8	31					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14749141	14749141	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14749141G>A	ENST00000253673.5	-	11	1360	c.1260C>T	c.(1258-1260)tcC>tcT	p.S420S	EMR3_ENST00000599900.1_Silent_p.S205S|EMR3_ENST00000344373.4_Silent_p.S368S|EMR3_ENST00000443157.2_Silent_p.S294S	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	420					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						CGGCGATGATGGAGCACAGCA	0.587000													8	37					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018170	62018170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62018170C>T	ENST00000578147.1	-	24	5548	c.5472G>A	c.(5470-5472)ggG>ggA	p.G1824G	SCN4A_ENST00000435607.1_Silent_p.G1824G			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1824					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GCACAGTCTGCCCTGGGGGAG	0.687000													6	64					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123451818	123451818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123451818C>T	ENST00000360772.3	-	12	1819	c.1441G>A	c.(1441-1443)Gac>Aac	p.D481N	MYLK_ENST00000360304.3_Missense_Mutation_p.D481N|MYLK_ENST00000475616.1_Missense_Mutation_p.D481N|MYLK_ENST00000346322.5_Intron|MYLK_ENST00000359169.1_Missense_Mutation_p.D481N			Q15746	MYLK_HUMAN	myosin light chain kinase	481	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GTCCCACTGTCCCTGGTCCGG	0.577000													13	54					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44676097	44676097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44676097C>T	ENST00000454036.1	+	15	1937	c.1861C>T	c.(1861-1863)Ctc>Ttc	p.L621F	SLC12A5_ENST00000243964.3_Missense_Mutation_p.L598F|SLC12A5_ENST00000539566.1_3'UTR	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	621					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTCTAGGACCCTCTCCTTCCT	0.572000													38	108					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681549	55681549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55681549C>T	ENST00000344514.1	-	1	509	c.510G>A	c.(508-510)ggG>ggA	p.G170G		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TCTCATTAGACCCACAGAAGC	0.433000													15	118					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105026744	105026744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:105026744C>T	ENST00000507740.1	+	17	2913	c.2677C>T	c.(2677-2679)Cgt>Tgt	p.R893C	RIMS2_ENST00000262231.10_Missense_Mutation_p.R918C|RIMS2_ENST00000406091.3_Missense_Mutation_p.R1079C|RIMS2_ENST00000436393.2_Missense_Mutation_p.R819C	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1141	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTCTCATCCTCGTACTGGGTC	0.418000										HNSCC(12;0.0054)			12	49					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198725306	198725306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:198725306C>T	ENST00000367376.2	+	33	4082	c.3911C>T	c.(3910-3912)tCa>tTa	p.S1304L	PTPRC_ENST00000352140.3_Missense_Mutation_p.S1256L|PTPRC_ENST00000348564.6_Missense_Mutation_p.S1145L|PTPRC_ENST00000442510.2_Missense_Mutation_p.S1306L|PTPRC_ENST00000594404.1_Missense_Mutation_p.S1143L	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1304					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AATCAAGGTTCATAGGAAAAG	0.413000													17	40					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92442776	92442776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92442776G>A	ENST00000370389.2	+	6	1500	c.576G>A	c.(574-576)aaG>aaA	p.K192K	BRDT_ENST00000394530.3_Silent_p.K219K|BRDT_ENST00000362005.3_Silent_p.K265K|BRDT_ENST00000402388.1_Silent_p.K265K|BRDT_ENST00000399546.2_Silent_p.K265K|BRDT_ENST00000484781.1_3'UTR	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		ATGTTGTGAAGACTGTTAAAG	0.348000													22	69					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136610419	136610419	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136610419G>A	ENST00000264156.2	-	12	1753	c.1693C>T	c.(1693-1695)Cgt>Tgt	p.R565C	MCM6_ENST00000492091.1_Intron	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	565					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	GAATAGACACGATCAATTGAT	0.368000													23	51					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180359940	180359940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:180359940C>T	ENST00000273654.4	-	19	2586	c.1967G>A	c.(1966-1968)cGa>cAa	p.R656Q	CCDC39_ENST00000442201.2_Missense_Mutation_p.R572Q			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	572					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AAGCATTTCTCGAGTACGCTT	0.323000													10	24					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115422330	115422330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:115422330C>T	ENST00000337530.6	+	4	2428	c.2132C>T	c.(2131-2133)tCc>tTc	p.S711F	KIAA1958_ENST00000536272.1_Missense_Mutation_p.S739F	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	711										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						AGGCTTGGCTCCCACAGCTGC	0.612000													27	74					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113171163	113171163	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113171163T>G	ENST00000401783.2	-	38	7053	c.6717A>C	c.(6715-6717)ggA>ggC	p.G2239G	SVEP1_ENST00000374469.1_Silent_p.G2216G|SVEP1_ENST00000297826.5_Silent_p.G165G	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2239	Sushi 14.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ATACAGGACTTCCGACTGACT	0.507000													17	140					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42458405	42458405	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42458405G>A	ENST00000318006.5	-	16	1794	c.1632C>T	c.(1630-1632)ttC>ttT	p.F544F	VPS39_ENST00000348544.4_Silent_p.F555F	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	555					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		CTGAGTAGGAGAAAATCAAAT	0.512000													21	63					0	0	1	0	0
TRMT10A	93587	broad.mit.edu	37	4	100472066	100472066	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100472066G>A	ENST00000273962.3	-	7	1039	c.727C>T	c.(727-729)Cga>Tga	p.R243*	TRMT10A_ENST00000394877.3_Nonsense_Mutation_p.R243*|TRMT10A_ENST00000394876.2_Nonsense_Mutation_p.R243*	NM_152292.4	NP_689505.1			tRNA methyltransferase 10 homolog A (S. cerevisiae)																		AAAACTTTTCGACTATTCATC	0.348000													10	27					0	0	1	0	0
IL1B	3553	broad.mit.edu	37	2	113587942	113587942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113587942G>A	ENST00000263341.2	-	7	1016	c.806C>T	c.(805-807)tCc>tTc	p.S269F	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	269					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	CTCTCTTTAGGAAGACACAAA	0.502000													24	100					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130788431	130788431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:130788431C>T	ENST00000276708.4	-	3	1202	c.321G>A	c.(319-321)ggG>ggA	p.G107G		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	107						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CAGAGGCCTCCCCTGACACAC	0.478000													20	89					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88583166	88583166	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88583166C>T	ENST00000418177.2	-	3	1186	c.819G>A	c.(817-819)gtG>gtA	p.V273V	GRM5_ENST00000455756.2_Silent_p.V273V|GRM5_ENST00000305447.4_Silent_p.V273V|GRM5_ENST00000393297.1_Silent_p.V273V|GRM5_ENST00000305432.5_Silent_p.V273V			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	273					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AGCAGGCCACCACCCGGGCCT	0.552000													28	62					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89943398	89943398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89943398G>A	ENST00000405460.2	+	17	3202	c.3106G>A	c.(3106-3108)Gtc>Atc	p.V1036I		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1036					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GACTTGCATGGTCCAGTATGC	0.438000													23	73					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109695723	109695723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:109695723G>A	ENST00000465301.2	+	3	2124	c.1878G>A	c.(1876-1878)acG>acA	p.T626T	RGAG1_ENST00000540313.1_Silent_p.T626T	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	626										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						CCTCAGGAACGATGTTCACGG	0.502000													40	23					0	0	1	0	0
TTC22	55001	broad.mit.edu	37	1	55266666	55266666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55266666G>A	ENST00000371276.4	-	1	274	c.171C>T	c.(169-171)ctC>ctT	p.L57L	TTC22_ENST00000371274.4_Silent_p.L57L	NM_001114108.1	NP_001107580.1	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22	57							binding			kidney(1)|large_intestine(1)|lung(7)|skin(1)	10						CCGCCAGCTGGAGCTCCTGCC	0.701000													11	17					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5323135	5323135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5323135G>A	ENST00000380224.1	-	1	91	c.42C>T	c.(40-42)ggC>ggT	p.G14G	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCCCAAGAAGCCAGTCAGCA	0.463000											OREG0003718	type=REGULATORY REGION|Gene=OR51B4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	23	77					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95194801	95194801	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:95194801C>T	ENST00000354268.4	+	12	1679	c.1606C>T	c.(1606-1608)Ctg>Ttg	p.L536L	SMARCAD1_ENST00000509418.1_Silent_p.L106L|SMARCAD1_ENST00000457823.2_Silent_p.L536L			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	536	Helicase ATP-binding.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		CATTGCATTTCTGGCATACCT	0.308000													19	38					0	0	1	0	0
IGHV3-74	28408	broad.mit.edu	37	14	107218706	107218706	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107218706G>A	ENST00000424969.2	-	0	556																											CCGTGTCCTCGGCTCTCAGAC	0.552000													129	295					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161010697	161010697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161010697C>T	ENST00000447678.1	-	25	3955	c.3835G>A	c.(3835-3837)Gga>Aga	p.G1279R	LPA_ENST00000316300.5_Missense_Mutation_p.G1279R	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3787	Kringle 12.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TAACTCTGTCCATCACCATGG	0.473000													25	57					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43359763	43359763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43359763G>A	ENST00000401467.2	-	1	80	c.9C>T	c.(7-9)ccC>ccT	p.P3P	PSG10P_ENST00000597171.1_RNA			Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	3						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GGGCTGAGAGGGGCCCCATGG	0.582000													39	222					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3076327	3076327	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3076327C>T	ENST00000397461.1	+	16	2179	c.1795C>T	c.(1795-1797)Ccc>Tcc	p.P599S	CNTN4_ENST00000397459.2_Missense_Mutation_p.P271S|CNTN4_ENST00000418658.1_Missense_Mutation_p.P599S|CNTN4_ENST00000427331.1_Missense_Mutation_p.P599S|CNTN4_ENST00000448906.2_Missense_Mutation_p.P271S|CNTN4_ENST00000358480.3_Missense_Mutation_p.P380S	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	599	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding	p.P271S(1)|p.P599S(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TCCTCCAGGTCCCCCAGAGGC	0.527000													13	41					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70961825	70961825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70961825G>A	ENST00000357250.6	-	28	2028	c.1870C>T	c.(1870-1872)Cct>Tct	p.P624S	COL9A1_ENST00000370499.4_Missense_Mutation_p.P381S|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000320755.7_Missense_Mutation_p.P381S	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	624	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						ATACTCACAGGAAGCCCCTGG	0.483000													56	110					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64981565	64981565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:64981565G>A	ENST00000268603.4	-	13	2947	c.2332C>T	c.(2332-2334)Cgt>Tgt	p.R778C	CDH11_ENST00000566827.1_Missense_Mutation_p.R652C|CDH11_ENST00000394156.3_3'UTR	NM_001797.2	NP_001788.2	P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	778					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TTCTTAAAACGAGGTCCCCAG	0.458000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			18	140					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21702955	21702955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21702955G>A	ENST00000388958.3	+	8	687	c.686G>A	c.(685-687)aGa>aAa	p.R229K	OTOA_ENST00000388956.4_Missense_Mutation_p.R150K|OTOA_ENST00000286149.4_Missense_Mutation_p.R229K	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	229					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		CATTCCCAGAGAGCTCTCTAT	0.488000													10	51					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48160882	48160882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:48160882C>T	ENST00000244043.4	-	4	510	c.481G>A	c.(481-483)Gag>Aag	p.E161K	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	161					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	AGACCCATCTCGTGCCAGCCA	0.597000													25	89					0	0	1	0	0
SH2D1B	117157	broad.mit.edu	37	1	162368759	162368759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:162368759G>A	ENST00000367929.2	-	3	426	c.317C>T	c.(316-318)cCc>cTc	p.P106L	SH2D1B_ENST00000359567.3_Intron	NM_053282.4	NP_444512.2	O14796	SH21B_HUMAN	SH2 domain containing 1B	106										kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TCTCAAGCTGGGGCTGGTTCT	0.408000													34	73					0	0	1	0	0
FAH	2184	broad.mit.edu	37	15	80460615	80460615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:80460615C>T	ENST00000539156.1	+	6	2591	c.353C>T	c.(352-354)cCc>cTc	p.P118L	FAH_ENST00000558627.1_3'UTR|FAH_ENST00000261755.5_Missense_Mutation_p.P188L|FAH_ENST00000561421.1_Missense_Mutation_p.P188L|FAH_ENST00000407106.1_Missense_Mutation_p.P188L			P16930	FAAA_HUMAN	fumarylacetoacetate hydrolase (fumarylacetoacetase)	188					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCTAAGCCTCCCGTATATGGT	0.493000									Tyrosinemia, type 1				18	142					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73072164	73072164	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73072164G>A	ENST00000429829.1	-	0	424					NR_001564.2																						GGTATCCACGGCCCCGTTGGG	0.438000													8	4					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179547469	179547469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179547469C>T	ENST00000589042.1	-	135	33273	c.33049G>A	c.(33049-33051)Gag>Aag	p.E11017K	TTN_ENST00000342992.6_Missense_Mutation_p.E9773K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10700K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10700	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTCCCGCTCCTCGTATTCT	0.358000													10	200					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123888069	123888069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123888069C>T	ENST00000373855.1	+	14	2140	c.1880C>T	c.(1879-1881)aCc>aTc	p.T627I	CNTRL_ENST00000373850.1_Missense_Mutation_p.T75I|CNTRL_ENST00000238341.5_Missense_Mutation_p.T627I|CNTRL_ENST00000373847.1_Missense_Mutation_p.T75I			Q7Z7A1	CNTRL_HUMAN	centriolin	627					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						TACCTGGGGACCATTAAAGGC	0.478000													29	102					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220166353	220166353	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220166353C>T	ENST00000295718.2	-	7	1323	c.1083G>A	c.(1081-1083)ctG>ctA	p.L361L	PTPRN_ENST00000409251.3_Silent_p.L361L|AC114803.3_ENST00000417355.1_RNA|PTPRN_ENST00000423636.2_Silent_p.L271L	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	361					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GCAGCAGGGTCAGGAGTGTGG	0.637000													36	78					0	0	1	0	0
PDZD3	79849	broad.mit.edu	37	11	119058284	119058284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119058284C>T	ENST00000531114.1	+	4	1279	c.730C>T	c.(730-732)Cct>Tct	p.P244S	PDZD3_ENST00000392817.2_Missense_Mutation_p.P244S|PDZD3_ENST00000355547.5_Missense_Mutation_p.P178S|PDZD3_ENST00000525131.1_Missense_Mutation_p.P165S|PDZD3_ENST00000322712.4_Missense_Mutation_p.P178S			Q86UT5	NHRF4_HUMAN	PDZ domain containing 3	244	PDZ 2.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	14	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		CAATCAGGGTCCTTTCTGGTT	0.582000													3	8					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247694907	247694907	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247694907G>A	ENST00000366487.3	-	2	1268	c.907C>T	c.(907-909)Cgg>Tgg	p.R303W	GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000527541.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			ACCATGTGCCGGAGGGCGCTC	0.517000													21	52					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141625347	141625347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141625347C>T	ENST00000389484.3	-	27	5362	c.4391G>A	c.(4390-4392)cGa>cAa	p.R1464Q		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1464					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCATGACCTCGGATGATTTC	0.403000										TSP Lung(27;0.18)			30	96					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431712	140431712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140431712C>T	ENST00000306549.3	+	1	734	c.657C>T	c.(655-657)tcC>tcT	p.S219S		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		219	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGGCGGGTCCCCGCCTAAGT	0.592000													7	17					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165383593	165383593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165383593C>T	ENST00000263915.3	-	4	1072	c.534G>A	c.(532-534)ggG>ggA	p.G178G	GRB14_ENST00000543549.1_Silent_p.G91G	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	178	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						CTTCTTCTATCCCCCAGTTGG	0.328000													28	74					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77400934	77400934	+	Silent	SNP	G	G	A	rs149732972		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77400934G>A	ENST00000451710.3	-	21	3012	c.2775C>T	c.(2773-2775)ttC>ttT	p.F925F	TRPM6_ENST00000376864.4_Silent_p.F925F|TRPM6_ENST00000361255.3_Silent_p.F920F|TRPM6_ENST00000360774.1_Silent_p.F925F|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Silent_p.F920F			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	925					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						ATCGAAGGACGAAGCCAGCTG	0.478000													32	128					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99898318	99898318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:99898318C>T	ENST00000547776.2	-	10	1373	c.1374G>A	c.(1372-1374)atG>atA	p.M458I	ANKS1B_ENST00000329257.7_Missense_Mutation_p.M458I|ANKS1B_ENST00000547010.1_Missense_Mutation_p.M38I	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	458						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CAGCTGTGTCCATGAGATCAC	0.393000													22	28					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62768205	62768205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62768205C>T	ENST00000336232.2	-	3	559	c.424G>A	c.(424-426)Gac>Aac	p.D142N	SLC22A8_ENST00000311438.8_Missense_Mutation_p.D142N|SLC22A8_ENST00000542795.1_5'UTR|SLC22A8_ENST00000545207.1_Missense_Mutation_p.D51N|SLC22A8_ENST00000535878.1_Missense_Mutation_p.D19N|SLC22A8_ENST00000430500.2_Missense_Mutation_p.D142N	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	142					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						TCAGACAGGTCTCCAAGCACG	0.562000													17	45					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57004472	57004472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57004472C>T	ENST00000606794.1	-	1	203	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	3						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TCACCACCTTCCTCCATGCTG	0.562000													21	38					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179562850	179562850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179562850G>A	ENST00000444136.1	+	3	738	c.488G>A	c.(487-489)cGa>cAa	p.R163Q	TDRD5_ENST00000367614.1_Missense_Mutation_p.R163Q|TDRD5_ENST00000294848.8_Missense_Mutation_p.R163Q	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	163	Lotus/OST-HTH 2.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						AGATTTGGACGATCATTCCAA	0.408000													8	123					0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41033329	41033329	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41033329C>T	ENST00000380620.3	+	5	1435	c.843C>T	c.(841-843)atC>atT	p.I281I	AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000343118.4_Silent_p.I281I|B3GALT5_ENST00000380618.1_Silent_p.I281I|B3GALT5_ENST00000398714.2_Silent_p.I281I			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	281					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				TCAGGAGGATCGTGGCCTGCC	0.577000													27	65					0	0	1	0	0
IGKV6D-41	28869	broad.mit.edu	37	2	90108537	90108537	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90108537C>T	ENST00000390271.2	+	0	34																											GAGATGGTGTCCCCGTTGCAA	0.408000													22	67					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	198051774	198051774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:198051774G>A	ENST00000328737.2	-	2	85	c.9C>T	c.(7-9)atC>atT	p.I3I	ANKRD44_ENST00000450567.1_Silent_p.I3I|ANKRD44_ENST00000539527.1_5'UTR|ANKRD44_ENST00000409919.1_Silent_p.I28I|ANKRD44_ENST00000409153.1_Silent_p.I28I|ANKRD44_ENST00000282272.8_Silent_p.I20I			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	28							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CAGTTTTATGGATGAGCATCC	0.428000													74	162					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	170020883	170020883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170020883C>T	ENST00000295797.4	+	18	2064	c.1759C>T	c.(1759-1761)Cct>Tct	p.P587S		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	587	AGC-kinase C-terminal.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GTATATCAATCCTCTTTTGAT	0.333000													33	81					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56524877	56524877	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56524877C>T	ENST00000394048.5	+	4	885	c.621C>T	c.(619-621)atC>atT	p.I207I	ESYT1_ENST00000541590.1_Silent_p.I207I|ESYT1_ENST00000267113.4_Silent_p.I207I	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	207						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						AAGAGCAGATCCTGCTGGACT	0.517000													5	51					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934929	28934929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28934929G>A	ENST00000257192.4	+	15	2982	c.2770G>A	c.(2770-2772)Gaa>Aaa	p.E924K	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG1_ENST00000462981.2_Missense_Mutation_p.E283K|RP11-534N16.1_ENST00000581856.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	924					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GGTAGTGACAGAAAGAGTAAT	0.453000													48	185					0	0	1	0	0
PPP1R11	6992	broad.mit.edu	37	6	30037021	30037021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30037021C>T	ENST00000376772.3	+	3	642	c.319C>T	c.(319-321)Ccc>Tcc	p.P107S	PPP1R11_ENST00000376765.2_Missense_Mutation_p.P55S|PPP1R11_ENST00000376763.1_Missense_Mutation_p.P55S|PPP1R11_ENST00000376773.1_Missense_Mutation_p.P55S|PPP1R11_ENST00000376769.2_Missense_Mutation_p.P55S|PPP1R11_ENST00000376758.1_Missense_Mutation_p.P55S	NM_021959.2	NP_068778.1	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 11	107	Pro-rich.					soluble fraction	protein binding|protein phosphatase inhibitor activity			lung(2)|ovary(1)|prostate(1)|skin(2)	6						AGGACCGACCCCCACCACCCC	0.617000													68	125					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222216	140222216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140222216C>T	ENST00000531613.1	+	1	1310	c.1310C>T	c.(1309-1311)gCc>gTc	p.A437V	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.A437V|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGCTGTGGGCCACCGCCAGC	0.652000													31	33					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21268095	21268095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21268095G>A	ENST00000602326.1	-	12	1985	c.1402C>T	c.(1402-1404)Ctt>Ttt	p.L468F	EIF4G3_ENST00000544689.1_5'UTR|EIF4G3_ENST00000356916.3_Missense_Mutation_p.L473F|EIF4G3_ENST00000536266.1_Missense_Mutation_p.L66F|EIF4G3_ENST00000264211.8_Missense_Mutation_p.L462F|EIF4G3_ENST00000374935.3_Intron|EIF4G3_ENST00000374937.3_Missense_Mutation_p.L468F|EIF4G3_ENST00000374927.4_Missense_Mutation_p.L462F|EIF4G3_ENST00000400422.1_Missense_Mutation_p.L462F	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	462					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCTTCACTAAGGCAAGTTCTT	0.438000													65	230					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909381	123909381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123909381C>T	ENST00000330487.5	-	1	336	c.328G>A	c.(328-330)Gag>Aag	p.E110K		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E110*(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGGAAACACTCGGTGCTCCCC	0.552000													53	81					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185232257	185232257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185232257C>T	ENST00000296252.4	-	8	1176	c.1035G>A	c.(1033-1035)ggG>ggA	p.G345G	LIPH_ENST00000424591.2_Silent_p.G311G	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	345					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TGGTAATGTCCCCTCTTCTTA	0.378000													26	86					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50501529	50501529	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50501529C>T	ENST00000301149.3	+	6	1024	c.792C>T	c.(790-792)acC>acT	p.T264T	GPD1_ENST00000547190.1_Intron|GPD1_ENST00000548814.1_Silent_p.T241T	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	264					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	TGATCACTACCTGCTATGGAG	0.592000													17	171					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201023684	201023684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201023684G>A	ENST00000362061.3	-	29	3841	c.3615C>T	c.(3613-3615)ttC>ttT	p.F1205F	CACNA1S_ENST00000367338.3_Intron	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1205					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGGAGGCCAGGAAAGTCTGTG	0.597000													5	22					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241535813	241535813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241535813C>T	ENST00000391984.2	+	8	1552	c.1356C>T	c.(1354-1356)gaC>gaT	p.D452D	CAPN10_ENST00000404753.3_Silent_p.D452D|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000354082.4_Intron|CAPN10_ENST00000352879.4_Intron	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	452	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		ATGCATACGACCGGGAGGTCC	0.652000													13	86					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	95001514	95001514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:95001514G>A	ENST00000265627.5	-	4	348	c.338C>T	c.(337-339)cCa>cTa	p.P113L	PON1_ENST00000542556.1_Intron|PON3_ENST00000427422.1_Missense_Mutation_p.P113L	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			GATCCCATGTGGATTAAATAA	0.393000													35	93					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10419245	10419245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10419245G>A	ENST00000226207.5	-	5	597	c.503C>T	c.(502-504)aCt>aTt	p.T168I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	168	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CCACTCACCAGTCAGCATGAA	0.423000													73	92					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78322274	78322274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78322274C>T	ENST00000255189.3	-	13	2191	c.2163G>A	c.(2161-2163)gaG>gaA	p.E721E	DMGDH_ENST00000380311.4_Silent_p.E520E|DMGDH_ENST00000540686.1_Silent_p.E341E	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	721					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TGAAGGCTTTCTCCAGGCGTA	0.423000													65	142					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263760	39263760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39263760C>T	ENST00000280481.7	+	1	2495	c.2279C>T	c.(2278-2280)aCc>aTc	p.T760I		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	760					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCACTGGGTACCTTGGTCTTG	0.527000													21	69					0	0	1	0	0
GOT1	2805	broad.mit.edu	37	10	101180539	101180539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101180539G>A	ENST00000370508.5	-	2	169	c.142C>T	c.(142-144)Ccc>Tcc	p.P48S	GOT1_ENST00000471741.1_5'UTR|GOT1_ENST00000543866.1_Missense_Mutation_p.P27S	NM_002079.2	NP_002070.1	P17174	AATC_HUMAN	glutamic-oxaloacetic transaminase 1, soluble	48					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)	16		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAAACCCAGGGATGGCAGTCA	0.473000													28	117					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182026917	182026917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:182026917C>T	ENST00000339948.3	-	2	436	c.229G>A	c.(229-231)Gag>Aag	p.E77K		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						TTCTCTTCCTCTTTGCCCAGT	0.557000													19	53					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101188637	101188637	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101188637G>A	ENST00000313669.7	+	0	914				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		GGGCCTCCAGGGCCCCGTGGG	0.687000													15	19					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11780534	11780534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11780534C>T	ENST00000381486.2	+	33	6104	c.5804C>T	c.(5803-5805)gCc>gTc	p.A1935V	GREB1_ENST00000234142.5_Missense_Mutation_p.A1935V|GREB1_ENST00000396123.1_Missense_Mutation_p.A933V	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1935						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACCGCCAATGCCAGGGAAGAC	0.602000													21	126					0	0	1	0	0
NNMT	4837	broad.mit.edu	37	11	114167333	114167333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:114167333G>A	ENST00000535401.1	+	3	319	c.55G>A	c.(55-57)Gat>Aat	p.D19N	NNMT_ENST00000299964.3_Missense_Mutation_p.D19N|RP11-64D24.2_ENST00000544925.1_RNA			P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	19					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	TAACCCTCGGGATTACCTAGA	0.428000													33	74					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169183279	169183279	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169183279C>T	ENST00000393743.3	-	24	3436	c.3144_splice	c.e24-1	p.E1049_splice	DDX60_ENST00000505393.1_5'UTR	NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1049							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		GGGCACAGTTCCTTGAAAACA	0.308000													18	43					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101739420	101739420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101739420C>T	ENST00000261637.4	+	37	4868	c.4694C>T	c.(4693-4695)aCt>aTt	p.T1565I		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1565					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GTACAACTTACTCATTACCAT	0.358000													23	87					0	0	1	0	0
ISX	91464	broad.mit.edu	37	22	35478537	35478537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:35478537C>T	ENST00000308700.6	+	2	1208	c.256C>T	c.(256-258)Cgt>Tgt	p.R86C	ISX_ENST00000404699.2_Missense_Mutation_p.R86C	NM_001008494.1	NP_001008494.1	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	86						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R86C(2)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(12)|ovary(3)|prostate(1)|skin(4)	26						GCGGAGGGTTCGTACCACCTT	0.557000													35	101					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301421	11301421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11301421C>T	ENST00000397056.1	+	3	889	c.698C>T	c.(697-699)tCc>tTc	p.S233F	HRH1_ENST00000431010.2_Missense_Mutation_p.S233F|HRH1_ENST00000438284.2_Missense_Mutation_p.S233F	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	233					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TCCCTCCCTTCCTTCTCAGAA	0.532000													10	62					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26747146	26747146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26747146C>T	ENST00000529632.2	+	12	2732	c.2536C>T	c.(2536-2538)Ctg>Ttg	p.L846L	SEZ6L_ENST00000360929.3_Intron|SEZ6L_ENST00000411842.2_Silent_p.L43L|SEZ6L_ENST00000402979.1_Silent_p.L619L|SEZ6L_ENST00000404234.3_Silent_p.L846L|SEZ6L_ENST00000343706.4_Silent_p.L846L|SEZ6L_ENST00000403121.1_Silent_p.L619L|SEZ6L_ENST00000248933.6_Silent_p.L846L	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	846	Sushi 4.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GAGTTCTCTTCTGACCTGCTA	0.552000													39	77					0	0	1	0	0
UGT2A2	574537	broad.mit.edu	37	4	70505136	70505136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70505136C>T	ENST00000457664.2	-	1	222	c.223G>A	c.(223-225)Gat>Aat	p.D75N	UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000503640.1_Intron|UGT2A1_ENST00000514019.1_Missense_Mutation_p.D276N	NM_001105677.2	NP_001099147.2																					ACAGGAGAATCGGGATTGGAG	0.353000													41	83					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113276350	113276350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113276350G>A	ENST00000401783.2	-	4	1337	c.1001C>T	c.(1000-1002)cCa>cTa	p.P334L	SVEP1_ENST00000374469.1_Missense_Mutation_p.P311L|SVEP1_ENST00000374461.1_Missense_Mutation_p.P311L|SVEP1_ENST00000302728.8_Missense_Mutation_p.P334L|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	334					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GATTCCTCCTGGTGAGCCTTC	0.512000													7	9					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699765	48699765	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48699765G>A	ENST00000544264.1	-	1	583	c.303C>T	c.(301-303)ccC>ccT	p.P101P	CELSR3_ENST00000164024.4_Silent_p.P101P			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	101					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTGCTCAGGGGGCCCTCGAC	0.657000													63	161					0	0	1	0	0
PARK7	11315	broad.mit.edu	37	1	8025434	8025434	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8025434C>T	ENST00000493678.1	+	3	208	c.141C>T	c.(139-141)agC>agT	p.S47S	PARK7_ENST00000497113.1_3'UTR|PARK7_ENST00000338639.5_Silent_p.S47S|PARK7_ENST00000377491.1_Silent_p.S47S|PARK7_ENST00000377493.5_Silent_p.S47S|PARK7_ENST00000377488.1_Silent_p.S47S			Q99497	PARK7_HUMAN	parkinson protein 7	47					autophagy|cell death|cellular response to hydrogen peroxide|inflammatory response|mitochondrion organization|negative regulation of cell death|negative regulation of protein binding|neuroprotection|protein stabilization|regulation of androgen receptor signaling pathway|regulation of inflammatory response|single fertilization	mitochondrion|nucleus	mRNA binding|peptidase activity|peroxidase activity|protein homodimerization activity			large_intestine(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;1.28e-70)|GBM - Glioblastoma multiforme(8;3.05e-36)|Colorectal(212;6.83e-08)|COAD - Colon adenocarcinoma(227;7.51e-06)|Kidney(185;5.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000414)|KIRC - Kidney renal clear cell carcinoma(229;0.000967)|STAD - Stomach adenocarcinoma(132;0.00102)|READ - Rectum adenocarcinoma(331;0.0649)		TACAGTGTAGCCGTGATGTGG	0.403000													29	55					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44691437	44691437	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44691437G>A	ENST00000290231.6	-	8	1406	c.1242C>T	c.(1240-1242)ctC>ctT	p.L414L		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				TAGCAGAGGGGAGCACTTGGC	0.617000													44	110					0	0	1	0	0
IGLV4-69	28784	broad.mit.edu	37	22	22385778	22385778	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22385778C>T	ENST00000390282.2	+	0	327				PRAMEF24P_ENST00000337471.4_RNA																							TCTCAGGCTCCAGCTCTGGGG	0.577000													27	65					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39805130	39805130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39805130C>T	ENST00000248668.4	-	1	846	c.847G>A	c.(847-849)Gac>Aac	p.D283N		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	283	LRRCT.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AAGTAGCGGTCGGTGAGGTGT	0.701000													3	27					0	0	1	0	0
GPR1	2825	broad.mit.edu	37	2	207041526	207041526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207041526C>T	ENST00000407325.2	-	3	808	c.446G>A	c.(445-447)cGa>cAa	p.R149Q	GPR1_ENST00000437420.1_Missense_Mutation_p.R149Q	NM_001098199.1|NM_001261452.1|NM_001261453.1|NM_001261454.1|NM_001261455.1|NM_005279.3	NP_001091669.1|NP_001248381.1|NP_001248382.1|NP_001248383.1|NP_001248384.1|NP_005270.2	P46091	GPR1_HUMAN	G protein-coupled receptor 1	149						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	18		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		CTTGAGGGTTCGATGCCGATG	0.463000													35	86					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109182393	109182393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109182393G>A	ENST00000326495.5	-	15	2614	c.2521C>T	c.(2521-2523)Cct>Tct	p.P841S	SSH1_ENST00000360239.3_Missense_Mutation_p.P529S	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	841					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTGGAGGGAGGTGCTGGGTCT	0.657000													24	35					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476416	57476416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57476416G>A	ENST00000371236.2	-	14	1883	c.1620C>T	c.(1618-1620)ccC>ccT	p.P540P	DAB1_ENST00000420954.2_Silent_p.P538P|DAB1_ENST00000439789.2_Silent_p.P454P|DAB1_ENST00000371234.4_Silent_p.P540P|DAB1_ENST00000371231.1_Silent_p.P573P|DAB1_ENST00000414851.2_Silent_p.P522P|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	573					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCTCCCCACTGGGCTCACCAA	0.443000													38	98					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2336706	2336706	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2336706G>A	ENST00000301732.5	-	22	3967	c.3267C>T	c.(3265-3267)gaC>gaT	p.D1089D	ABCA3_ENST00000382381.3_Silent_p.D1031D	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1089					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				CGTTAAACTGGTCCTTGGCAG	0.632000													16	55					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45444226	45444226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45444226G>A	ENST00000321429.4	+	25	3576	c.3169G>A	c.(3169-3171)Ggg>Agg	p.G1057R	DUOX1_ENST00000561166.1_Missense_Mutation_p.G703R|DUOX1_ENST00000389037.3_Missense_Mutation_p.G1057R	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	1057	Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CATCGCTGGGGGGCTTTTCCT	0.602000													9	29					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51170907	51170907	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51170907G>A	ENST00000293441.1	-	22	4328	c.4310C>T	c.(4309-4311)cCg>cTg	p.P1437L	SHANK1_ENST00000359082.3_Missense_Mutation_p.P1428L|SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000391813.1_Missense_Mutation_p.P824L|SHANK1_ENST00000391814.1_Missense_Mutation_p.P1445L	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1437					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGCGGCGGGCGGGCTGGCGGG	0.796000													4	2					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95764944	95764944	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:95764944G>A	ENST00000311106.3	-	2	495	c.258C>T	c.(256-258)atC>atT	p.I86I	PCSK1_ENST00000508626.1_Silent_p.I39I|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	86					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCTCTTAGTGATATGAAAGG	0.318000													29	61					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118375153	118375153	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118375153C>A	ENST00000534358.1	+	27	8569	c.8546C>A	c.(8545-8547)cCt>cAt	p.P2849H	KMT2A_ENST00000354520.4_Missense_Mutation_p.P2808H|KMT2A_ENST00000389506.5_Missense_Mutation_p.P2846H	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AATATCCTGCCTTCAGACATT	0.428000													46	150					1.06522e-23	1.07205e-23	1	1	0
TBP	6908	broad.mit.edu	37	6	170873696	170873696	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:170873696C>T	ENST00000392092.2	+	4	840	c.561C>T	c.(559-561)gcC>gcT	p.A187A	TBP_ENST00000230354.6_Silent_p.A187A|TBP_ENST00000540980.1_Silent_p.A167A	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	187				A -> R (in Ref. 3; AAC03409).	cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		CACTTCGTGCCCGAAACGCCG	0.318000													17	26					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2444192	2444192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2444192C>T	ENST00000452833.1	-	1	83	c.75G>A	c.(73-75)agG>agA	p.R25R	TRPM5_ENST00000155858.6_Silent_p.R25R|TRPM5_ENST00000533060.1_Silent_p.R25R|TRPM5_ENST00000528453.1_Silent_p.R25R			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	25						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGACCTCGCCCCTGTGCAAGC	0.652000													7	66					0	0	1	0	0
CCKAR	886	broad.mit.edu	37	4	26484791	26484791	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:26484791C>T	ENST00000295589.3	-	4	935	c.741G>A	c.(739-741)aaG>aaA	p.K247K		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	247					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	TAGCAGACTTCTTCTGGCTAG	0.373000													53	140					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49031038	49031038	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:49031038G>A	ENST00000380950.2	-	27	4728	c.4541C>T	c.(4540-4542)cCt>cTt	p.P1514L	CEP152_ENST00000399334.3_Missense_Mutation_p.P1458L	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	1458					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TGATTCAGAAGGACCAGGGGT	0.398000													26	66					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3157830	3157830	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3157830G>A	ENST00000262958.3	+	6	1107	c.849G>A	c.(847-849)gaG>gaA	p.E283E		NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	283					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		ACATCCTGGAGGAGAAAATCC	0.488000													72	163					0	0	1	0	0
EMILIN1	11117	broad.mit.edu	37	2	27302010	27302010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27302010C>T	ENST00000380320.4	+	1	576	c.77C>T	c.(76-78)cCt>cTt	p.P26L		NM_007046.3	NP_008977.1	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1	26					cell adhesion	collagen				breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(14)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	26	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCTACCCTCCTCGAGGTTTC	0.716000													12	25					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39893908	39893908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:39893908C>T	ENST00000564288.1	+	63	17529	c.16752C>T	c.(16750-16752)ttC>ttT	p.F5584F	MACF1_ENST00000289893.4_Silent_p.F4024F|MACF1_ENST00000545844.1_Silent_p.F3522F|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000361689.2_Silent_p.F3522F|MACF1_ENST00000317713.7_Silent_p.F3522F|MACF1_ENST00000567887.1_Silent_p.F5621F			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5589					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTTCAGTGTTCGTAAAGGATT	0.448000													13	33					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14841576	14841576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14841576G>A	ENST00000380881.4	-	11	2568	c.1753C>T	c.(1753-1755)Cat>Tat	p.H585Y	FREM1_ENST00000380880.3_Missense_Mutation_p.H584Y|FREM1_ENST00000422223.2_Missense_Mutation_p.H584Y			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	584					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGGAAGCCATGGACAGGATAG	0.368000													51	94					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119770494	119770494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119770494C>T	ENST00000313400.4	-	7	1568	c.1468G>A	c.(1468-1470)Gac>Aac	p.D490N	ASTN2_ENST00000361209.2_Missense_Mutation_p.D439N|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.D490N			O75129	ASTN2_HUMAN	astrotactin 2	490						integral to membrane		p.D439N(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TTTAACCAGTCGGAGATGTCC	0.507000													15	50					0	0	1	0	0
IPO8	10526	broad.mit.edu	37	12	30790020	30790020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:30790020G>A	ENST00000256079.4	-	22	2929	c.2591C>T	c.(2590-2592)tCa>tTa	p.S864L	IPO8_ENST00000544829.1_Missense_Mutation_p.S659L	NM_006390.3	NP_006381.2	O15397	IPO8_HUMAN	importin 8	864					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(16)|liver(1)|lung(22)|prostate(2)|skin(2)|urinary_tract(2)	52	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GAAAAGAATTGAGGGAACAAT	0.438000													47	92					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72063173	72063173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:72063173G>A	ENST00000305425.4	-	7	2106	c.1684C>T	c.(1684-1686)Cct>Tct	p.P562S	DACH1_ENST00000359684.2_Missense_Mutation_p.P614S|DACH1_ENST00000313174.7_Missense_Mutation_p.P414S|DACH1_ENST00000354591.4_Missense_Mutation_p.P360S	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	612					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGTCCATCAGGAAACAGAAAA	0.463000													47	165					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90433300	90433300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:90433300G>A	ENST00000369393.3	-	39	5824	c.5709C>T	c.(5707-5709)ttC>ttT	p.F1903F	MDN1_ENST00000428876.1_Silent_p.F1903F			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1903					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TACTGGCAATGAACTCCATGT	0.333000													12	30					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205033876	205033876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205033876G>A	ENST00000331830.4	+	12	1801	c.1517G>A	c.(1516-1518)cGa>cAa	p.R506Q		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	506					axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTATCTGTGCGAGGTGAGGGC	0.537000													42	98					0	0	1	0	0
KLF14	136259	broad.mit.edu	37	7	130418345	130418345	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:130418345C>T	ENST00000310992.4	-	1	543	c.516G>A	c.(514-516)ggG>ggA	p.G172G		NM_138693.2	NP_619638.1	Q8TD94	KLF14_HUMAN	Kruppel-like factor 14	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Melanoma(18;0.0435)					CGGGGCCTGCCCCTAGGGCCC	0.741000													3	13					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284753	52284753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52284753C>T	ENST00000301190.6	+	5	1250	c.1023C>T	c.(1021-1023)tcC>tcT	p.S341S	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Silent_p.S216S|ANKRD33_ENST00000538991.1_Silent_p.S147S	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	216								p.S341S(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GAAGCAAGTCCGTGCCAGAGC	0.657000													10	27					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100376662	100376662	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100376662C>T	ENST00000262233.6	+	12	1462	c.1323C>T	c.(1321-1323)atC>atT	p.I441I	EML1_ENST00000327921.9_Silent_p.I429I|EML1_ENST00000334192.4_Silent_p.I460I	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	441						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GTGGCAACATCTTAGTATGGG	0.358000													23	60					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369443	56369443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56369443C>T	ENST00000301295.6	+	3	1106	c.684C>T	c.(682-684)ttC>ttT	p.F228F	NLRP4_ENST00000587891.1_Silent_p.F153F|NLRP4_ENST00000346986.5_Silent_p.F228F	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	228	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GACTCTTGTTCGTCATCGACA	0.552000													33	81					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128496919	128496919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128496919C>T	ENST00000325888.8	+	45	7766	c.7505C>T	c.(7504-7506)gCt>gTt	p.A2502V	FLNC_ENST00000346177.6_Missense_Mutation_p.A2469V|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2502	Interaction with INPPL1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CAGAGCCAGGCTGGGGACCCA	0.627000													8	43					0	0	1	0	0
RP11-64J4.2	0	broad.mit.edu	37	17	3214646	3214646	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3214646C>T	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							TAGCCATGGCCTATGACCGCT	0.567000													22	35					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21721262	21721262	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21721262C>T	ENST00000328843.6	+	31	5473	c.5442C>T	c.(5440-5442)gcC>gcT	p.A1814A	DNAH11_ENST00000409508.3_Silent_p.A1809A			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1814	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATGTCCATGCCAGAGACGTGG	0.388000									Kartagener syndrome				28	78					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439799	52439799	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52439799A>G	ENST00000242819.4	+	2	581	c.285A>G	c.(283-285)gaA>gaG	p.E95E		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	95						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CTTTCTGGGAAGAGGAGAAAA	0.468000													13	101					0	0	1	0	0
CCKBR	887	broad.mit.edu	37	11	6292205	6292205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6292205C>T	ENST00000525462.1	+	4	986	c.983C>T	c.(982-984)tCg>tTg	p.S328L	CCKBR_ENST00000334619.2_Intron|CCKBR_ENST00000532715.1_Intron|CCKBR_ENST00000532396.1_Intron			P32239	GASR_HUMAN	cholecystokinin B receptor	269					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TGGGGGGACTCGCCTTTTTCT	0.622000													14	34					0	0	1	0	0
CT47A6	728062	broad.mit.edu	37	X	120094383	120094383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:120094383C>T	ENST00000443600.2	-	1	954	c.700G>A	c.(700-702)Gcc>Acc	p.A234T	CT47A5_ENST00000419194.2_Intron	NM_001080141.1	NP_001073610.1	Q5JQC4	CT47A_HUMAN	cancer/testis antigen family 47, member A6	234										large_intestine(1)|lung(4)	5						TCTTCTGTGGCTGGTTCCTCT	0.687000													256	2					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784504	82784504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82784504C>T	ENST00000423517.2	-	2	1790	c.1453G>A	c.(1453-1455)Ggc>Agc	p.G485S	PCLO_ENST00000333891.8_Missense_Mutation_p.G485S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	435	10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.|Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTGCTGGGCCAGGCTGTTGA	0.607000													40	106					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72992819	72992819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72992819G>A	ENST00000268489.5	-	2	1898	c.1226C>T	c.(1225-1227)tCg>tTg	p.S409L	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	409					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CTTCAGTACCGAGCTGGTGAG	0.657000													20	147					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36069802	36069802	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36069802G>A	ENST00000303965.4	-	33	5331	c.4842C>T	c.(4840-4842)caC>caT	p.H1614H		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1614					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						GCTCCAGGCAGTGGGCCACCA	0.522000													27	135					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75866417	75866417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75866417C>T	ENST00000274364.6	+	4	613	c.316C>T	c.(316-318)Cat>Tat	p.H106Y	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	106	CH.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GTCTGGCCTTCATTTTCGACA	0.433000													25	78					0	0	1	0	0
FAM83E	54854	broad.mit.edu	37	19	49107064	49107064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49107064G>A	ENST00000263266.3	-	4	1052	c.863C>T	c.(862-864)tCc>tTc	p.S288F		NM_017708.3	NP_060178.2	Q2M2I3	FA83E_HUMAN	family with sequence similarity 83, member E	288										NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GAGCGGGCAGGAGGCCGCGTA	0.701000													13	31					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103498964	103498964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:103498964C>T	ENST00000372588.4	-	2	460	c.377G>A	c.(376-378)gGg>gAg	p.G126E		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	126					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						GGTTTGTGGCCCCTCCGCCGG	0.662000													8	41					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41900474	41900474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41900474C>T	ENST00000298919.7	+	4	668	c.280C>T	c.(280-282)Cct>Tct	p.P94S	PDZRN4_ENST00000539469.2_Missense_Mutation_p.P96S|PDZRN4_ENST00000402685.2_Missense_Mutation_p.P354S			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	354							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCCACCTACCCCTCCAGTGCC	0.483000													16	89					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152383234	152383234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152383234C>T	ENST00000271835.3	-	3	386	c.324G>A	c.(322-324)ggG>ggA	p.G108G	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	108					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGCGAGGCCCCAGAGTGGA	0.592000													108	322					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4281435	4281435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4281435C>T	ENST00000404826.2	+	43	6280	c.6141C>T	c.(6139-6141)atC>atT	p.I2047I	SDK1_ENST00000389531.3_Silent_p.I2027I|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2047					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GAAAGGGGATCTCCACCATGG	0.602000													10	30					0	0	1	0	0
CDKL3	51265	broad.mit.edu	37	5	133634402	133634402	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:133634402C>T	ENST00000265334.4	-	13	1838		c.e13-1		CDKL3_ENST00000523054.1_Splice_Site|CDKL3_ENST00000536186.1_Intron|CDKL3_ENST00000518409.1_Intron|CDKL3_ENST00000435240.2_Intron	NM_001113575.1	NP_001107047.1	Q8IVW4	CDKL3_HUMAN	cyclin-dependent kinase-like 3							cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(3)	11			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATCTCCACCCTAAAATTAGA	0.333000													48	125					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54963357	54963357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54963357C>T	ENST00000326764.5	+	3	605	c.126C>T	c.(124-126)gcC>gcT	p.A42A	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	42							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GGGAGAAGGCCCGTCAGGCCC	0.637000													26	79					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72360605	72360605	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72360605G>A	ENST00000441259.1	-	2	214	c.54C>T	c.(52-54)ccC>ccT	p.P18P	PRF1_ENST00000373209.2_Silent_p.P18P	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	18					apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						GGGCAGGGACGGGCAGGGGCA	0.677000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				5	18					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49166321	49166321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49166321G>A	ENST00000307885.4	-	16	3321	c.2627C>T	c.(2626-2628)tCt>tTt	p.S876F	ADCY6_ENST00000357869.3_Missense_Mutation_p.S823F|ADCY6_ENST00000550422.1_Missense_Mutation_p.S823F	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	876					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CTCATTGGAAGAAGCCCTGGT	0.512000													8	42					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354218	57354218	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57354218G>A	ENST00000314922.3	-	2	493	c.417C>T	c.(415-417)ttC>ttT	p.F139F	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Silent_p.F139F	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	139					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CCTTCTTCATGAAGCCCCCAT	0.532000													21	105					0	0	1	0	0
C17orf59	54785	broad.mit.edu	37	17	8092541	8092541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8092541G>A	ENST00000389017.4	-	1	1023	c.918C>T	c.(916-918)tcC>tcT	p.S306S		NM_017622.2	NP_060092.2	Q96GS4	CQ059_HUMAN	chromosome 17 open reading frame 59	306										large_intestine(2)|lung(3)|urinary_tract(1)	6						CTTCACCTAAGGAGTCCACAG	0.677000													23	51					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87730951	87730951	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:87730951G>A	ENST00000436978.1	+	46	7608	c.7128G>A	c.(7126-7128)ctG>ctA	p.L2376L	PTPN13_ENST00000511467.1_Silent_p.L2376L|PTPN13_ENST00000427191.2_Silent_p.L2352L|PTPN13_ENST00000316707.6_Silent_p.L2180L|PTPN13_ENST00000411767.2_Silent_p.L2371L	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2371	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TTTCTCATCTGAATTTCACTG	0.388000													38	84					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40114687	40114687	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40114687G>A	ENST00000324616.5	+	13	1747	c.1593G>A	c.(1591-1593)agG>agA	p.R531R		NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	531										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						ATGTAGAAAGGATGGCAAAAC	0.318000													25	78					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51379771	51379771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51379771G>A	ENST00000216392.7	-	13	1928	c.1596C>T	c.(1594-1596)ctC>ctT	p.L532L	PYGL_ENST00000544180.2_Silent_p.L498L|RP11-218E20.5_ENST00000557343.1_RNA|PYGL_ENST00000532462.1_Silent_p.L532L	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	532					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CGAGTTCCCGGAGGAAGACAT	0.478000													19	43					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11765357	11765357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11765357C>T	ENST00000381486.2	+	24	4525	c.4225C>T	c.(4225-4227)Ccc>Tcc	p.P1409S	GREB1_ENST00000234142.5_Missense_Mutation_p.P1409S|GREB1_ENST00000396123.1_Missense_Mutation_p.P407S	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1409						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CAAGAAGTTGCCCTTTGACTA	0.463000													104	262					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860201	16860201	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16860201T>C	ENST00000524140.2	+	6	1166	c.748T>C	c.(748-750)Ttg>Ctg	p.L250L	NWD1_ENST00000523826.1_Silent_p.L44L|NWD1_ENST00000379808.3_Silent_p.L250L|NWD1_ENST00000552788.1_Silent_p.L250L|NWD1_ENST00000339803.6_Silent_p.L115L|NWD1_ENST00000549814.1_Silent_p.L250L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	250							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAGCCGCGACTTGGTGAACCC	0.597000													21	47					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119451284	119451284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119451284G>A	ENST00000273390.5	+	9	1239	c.1162G>A	c.(1162-1164)Gac>Aac	p.D388N		NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		CAACTCAGAGGACTTTGTAGT	0.358000													15	42					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145895603	145895603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145895603C>T	ENST00000311104.2	-	1	150	c.74G>A	c.(73-75)gGa>gAa	p.G25E		NM_194251.2	NP_919227.2	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	25						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGGTACCCTCCGGCAAAGTG	0.542000													14	150					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65260194	65260194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65260194C>T	ENST00000389722.3	-	13	2240	c.2187G>A	c.(2185-2187)aaG>aaA	p.K729K	SPTB_ENST00000556626.1_Silent_p.K729K|SPTB_ENST00000542895.1_Silent_p.K729K|SPTB_ENST00000389721.5_Silent_p.K729K|SPTB_ENST00000389720.3_Silent_p.K729K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	729					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CAGCCAGGTCCTTCAGCTGGT	0.592000													14	40					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9225293	9225293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9225293C>T	ENST00000318602.7	-	30	4238	c.3931G>A	c.(3931-3933)Gaa>Aaa	p.E1311K		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	1311					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	ATGCTGTATTCCCCAGGCAGC	0.517000													62	121					0	0	1	0	0
TTC30A	92104	broad.mit.edu	37	2	178482356	178482356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:178482356G>A	ENST00000355689.4	-	1	1338	c.1074C>T	c.(1072-1074)ctC>ctT	p.L358L	AC073834.3_ENST00000357045.4_RNA	NM_152275.3	NP_689488.3	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	358					cell projection organization	cilium	binding	p.L358L(1)		autonomic_ganglia(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			AGAAGTCATAGAGATAGGGTG	0.473000													38	110					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214556972	214556972	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:214556972G>A	ENST00000366956.5	-	13	2420	c.2226C>T	c.(2224-2226)gcC>gcT	p.A742A	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	742					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TGGGGATGCGGGCCAGGGCCG	0.652000													21	47					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13715998	13715998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13715998C>T	ENST00000279593.3	-	13	4383	c.4174G>A	c.(4174-4176)Ggg>Agg	p.G1392R		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1392					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGTCGTCCCCAAAAGTGGGG	0.622000													13	30					0	0	1	0	0
OR7D2	162998	broad.mit.edu	37	19	9296535	9296535	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9296535C>T	ENST00000344248.2	+	1	257	c.78C>T	c.(76-78)ttC>ttT	p.F26F		NM_175883.2	NP_787079.1	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D, member 2	26					regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F26L(1)		breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	20						TACAGCCGTTCATATTTGGGC	0.493000													29	54					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401535	77401535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77401535G>A	ENST00000282849.5	-	4	999	c.581C>T	c.(580-582)cCt>cTt	p.P194L	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	194					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GTGACCCGCAGGGGAGCTGTA	0.507000													30	58					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18044404	18044404	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18044404G>A	ENST00000205890.5	+	22	5816	c.5478G>A	c.(5476-5478)agG>agA	p.R1826R	MYO15A_ENST00000412324.1_3'UTR	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1826	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					AGACCGTGAGGATCCGCAAGG	0.552000											OREG0024223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	16					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9798279	9798279	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9798279C>A	ENST00000302036.7	+	5	1215	c.872C>A	c.(871-873)cCg>cAg	p.P291Q	OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Missense_Mutation_p.P291Q|OGG1_ENST00000302003.7_Missense_Mutation_p.P291Q|OGG1_ENST00000344629.7_Missense_Mutation_p.P291Q|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000339511.5_Missense_Mutation_p.P291Q|OGG1_ENST00000449570.2_Missense_Mutation_p.P291Q	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	291					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					GCGAAGGGACCGAGCCCCCAG	0.602000								Base excision repair (BER), DNA glycosylases					18	47					1.00905e-13	1.01412e-13	1	1	0
SMPD3	55512	broad.mit.edu	37	16	68405281	68405281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68405281C>T	ENST00000219334.5	-	3	1407	c.804G>A	c.(802-804)agG>agA	p.R268R	SMPD3_ENST00000563226.1_Silent_p.R268R|SMPD3_ENST00000568373.1_Silent_p.R268R	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	268					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CAGCTCCGTTCCTGGCCTGGC	0.716000													14	22					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179545793	179545793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179545793G>A	ENST00000393371.2	-	8	1277	c.981C>T	c.(979-981)atC>atT	p.I327I	RASGEF1C_ENST00000361132.4_Silent_p.I327I|RASGEF1C_ENST00000522500.1_Silent_p.I176I			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	327	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTACCTCGAGGATGAAAAACT	0.607000													8	119					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115947732	115947732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115947732C>T	ENST00000251864.2	+	2	295	c.142C>T	c.(142-144)Cct>Tct	p.P48S	TDRD1_ENST00000422662.1_5'UTR|TDRD1_ENST00000369281.2_Missense_Mutation_p.P48S|TDRD1_ENST00000369282.1_Missense_Mutation_p.P48S|TDRD1_ENST00000369280.1_Missense_Mutation_p.P48S	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	48					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGGAACACTTCCTAACCACCC	0.373000													34	114					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20141139	20141139	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20141139G>A	ENST00000375121.2	-	1	632	c.456C>T	c.(454-456)gcC>gcT	p.A152A	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	152						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGCGCCGGGCTGCCACGT	0.607000													28	141					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439638	150439638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150439638C>T	ENST00000358647.3	+	3	778	c.411C>T	c.(409-411)gtC>gtT	p.V137V	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGAAAGAGGTCTTTGGGACAG	0.582000													34	100					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832027	61832027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61832027G>A	ENST00000280772.1	-	37	8803	c.8612C>T	c.(8611-8613)tCg>tTg	p.S2871L	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2871					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.S2871L(1)		NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AAGTACATGCGAAAGTTTTTC	0.398000													34	88					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4945269	4945269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4945269C>T	ENST00000345988.2	-	11	1324	c.1235G>A	c.(1234-1236)gGg>gAg	p.G412E	PPL_ENST00000590782.2_Missense_Mutation_p.G410E	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	412					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						CACCTGCTCCCCCTCAAAGTC	0.627000													15	46					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735093	41735093	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41735093C>T	ENST00000352645.4	+	9	971	c.714C>T	c.(712-714)gcC>gcT	p.A238A	ZC3H7B_ENST00000351589.4_Silent_p.A238A	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	254					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ACCTGCTGGCCCCCCTGGACA	0.667000													46	126					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168066390	168066390	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168066390C>T	ENST00000367838.1	-	5	768	c.455G>A	c.(454-456)tGg>tAg	p.W152*	GPR161_ENST00000539777.1_Nonsense_Mutation_p.W74*|GPR161_ENST00000537209.1_Nonsense_Mutation_p.W172*|GPR161_ENST00000546300.1_Nonsense_Mutation_p.W38*|GPR161_ENST00000361697.2_Nonsense_Mutation_p.W152*|GPR161_ENST00000367836.1_Nonsense_Mutation_p.W20*|GPR161_ENST00000271357.5_Nonsense_Mutation_p.W152*|GPR161_ENST00000367835.1_Nonsense_Mutation_p.W152*	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	152					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CGAGTGAAGCCAGATGTAGAC	0.552000													6	86					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62550251	62550251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62550251G>A	ENST00000371158.2	+	33	4422	c.4308G>A	c.(4306-4308)atG>atA	p.M1436I	INADL_ENST00000545929.1_Missense_Mutation_p.M109I|INADL_ENST00000316485.6_Missense_Mutation_p.M1436I|INADL_ENST00000543708.1_Missense_Mutation_p.M220I	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1436					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						GACAGGAAATGATTATAGAAA	0.468000													21	86					0	0	1	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737853	62737853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62737853G>A	ENST00000369768.1	-	1	671	c.332C>T	c.(331-333)cCc>cTc	p.P111L		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	111						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CTCCCCGAAGGGCCAGTACTG	0.607000													16	33					0	0	1	0	0
RAD51AP1	10635	broad.mit.edu	37	12	4662197	4662197	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4662197A>T	ENST00000228843.9	+	8	706	c.656A>T	c.(655-657)gAc>gTc	p.D219V	RAD51AP1_ENST00000544927.1_Missense_Mutation_p.D202V|RAD51AP1_ENST00000544931.1_3'UTR|RAD51AP1_ENST00000352618.4_Missense_Mutation_p.D202V|RAD51AP1_ENST00000543041.1_Missense_Mutation_p.D84V|RAD51AP1_ENST00000321524.7_Missense_Mutation_p.D219V	NM_001130862.1	NP_001124334.1	Q96B01	R51A1_HUMAN	RAD51 associated protein 1	219					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|RNA binding|single-stranded DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			GAGGATAATGACGAAGACTTC	0.318000													10	37					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168901	142168901	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142168901G>A	ENST00000454561.2	-	0	144																											TCCTGGGGAAGAGCCGAGTGA	0.592000													12	20					0	0	1	0	0
ZNF699	374879	broad.mit.edu	37	19	9408050	9408050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9408050G>A	ENST00000591998.1	-	5	620	c.392C>T	c.(391-393)tCc>tTc	p.S131F	ZNF699_ENST00000308650.3_Missense_Mutation_p.S131F			Q32M78	ZN699_HUMAN	zinc finger protein 699	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S131F(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GGAGAACCAGGAATCATTCCT	0.363000													34	45					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19339087	19339087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19339087C>T	ENST00000252575.5	+	8	2701	c.2658C>T	c.(2656-2658)gcC>gcT	p.A886A	NCAN_ENST00000538881.1_Silent_p.A337A	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	886					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GAGTTCCAGCCATGTCTACAC	0.602000													32	98					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46094342	46094342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46094342C>T	ENST00000323040.4	-	2	1727	c.783G>A	c.(781-783)gaG>gaA	p.E261E	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	261						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		AGACGCGCTCCTCGAAGCCGC	0.637000													8	57					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132445295	132445295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:132445295C>T	ENST00000333577.4	+	2	240	c.131C>T	c.(130-132)cCc>cTc	p.P44L	EP400_ENST00000330386.6_Missense_Mutation_p.P44L|EP400_ENST00000389562.2_Missense_Mutation_p.P44L|EP400_ENST00000332482.4_Missense_Mutation_p.P44L|EP400_ENST00000389561.2_Missense_Mutation_p.P44L			Q96L91	EP400_HUMAN	E1A binding protein p400	44					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCCTTCGCTCCCTCAGCAAGC	0.652000													24	30					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299405	58299405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58299405G>A	ENST00000377918.3	+	4	3483	c.3457G>A	c.(3457-3459)Gac>Aac	p.D1153N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1153					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCGGGGAAACGACCCTGTGGC	0.448000													38	119					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101051255	101051255	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101051255C>T	ENST00000360863.6	-	14	2264	c.2070G>A	c.(2068-2070)tgG>tgA	p.W690*	RGS22_ENST00000523437.1_Nonsense_Mutation_p.W678*|RGS22_ENST00000523287.1_Nonsense_Mutation_p.W509*	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	690					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CACTGTTCTTCCACAACTACA	0.353000													13	37					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489685	237489685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:237489685G>A	ENST00000272928.3	+	2	887	c.577G>A	c.(577-579)Gag>Aag	p.E193K		NM_020311.2	NP_064707.1			atypical chemokine receptor 3									p.E193K(1)									GTCCAACAATGAGACCTACTG	0.592000													33	116					0	0	1	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72958220	72958220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72958220G>A	ENST00000421285.3	+	16	1794	c.1794G>A	c.(1792-1794)gaG>gaA	p.E598E		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	598										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						AGGAGGAGGAGATGAAGGTAG	0.627000													32	321					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84527518	84527518	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84527518G>A	ENST00000286744.5	+	8	952	c.727_splice	c.e8-1	p.R243_splice	ADAMTSL3_ENST00000567476.1_Splice_Site_p.R243_splice	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	243						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTTTCCCAGGAGAAGAAAAT	0.398000													21	117					0	0	1	0	0
IFIH1	64135	broad.mit.edu	37	2	163138964	163138964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163138964G>A	ENST00000263642.2	-	6	1613	c.1218C>T	c.(1216-1218)tcC>tcT	p.S406S		NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	406	Helicase ATP-binding.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						TAATATCACAGGACTTGACAA	0.373000													33	71					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17697186	17697186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:17697186C>T	ENST00000353383.1	+	3	1393	c.924C>T	c.(922-924)ctC>ctT	p.L308L	RAI1_ENST00000261641.6_Silent_p.L308L	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	308	Gln-rich.					cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		ACCAAAACCTCGCCAAGTATC	0.627000													34	68					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7310146	7310146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7310146C>T	ENST00000537408.1	+	16	3163	c.2625C>T	c.(2623-2625)gtC>gtT	p.V875V	CLSTN3_ENST00000266546.6_Silent_p.V863V|CLSTN3_ENST00000331148.5_3'UTR			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	863					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						TGCTCATGGTCGTCCTGGGCC	0.662000													11	26					0	0	1	0	0
NLRP6	171389	broad.mit.edu	37	11	280753	280753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:280753C>T	ENST00000534750.1	+	4	1224	c.1019C>T	c.(1018-1020)tCc>tTc	p.S340F	NLRP6_ENST00000312165.5_Missense_Mutation_p.S340F	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	340	NACHT.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGCCTGTGTTCCCCGCAGTGC	0.687000													23	41					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502394	90502394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90502394G>A	ENST00000325643.5	+	4	3058	c.2992G>A	c.(2992-2994)Gag>Aag	p.E998K		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GGCTGGGAACGAGGCATGGCT	0.582000													10	52					0	0	1	0	0
MAN1A1	4121	broad.mit.edu	37	6	119509578	119509578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:119509578C>T	ENST00000368468.3	-	11	2152	c.1711G>A	c.(1711-1713)Gcc>Acc	p.A571T		NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	571					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		ACCTCTACGGCTTCCCAGGCC	0.348000													43	89					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181420	128181420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:128181420C>T	ENST00000469083.1	-	2	3226	c.669G>A	c.(667-669)aaG>aaA	p.K223K	DNAJB8_ENST00000319153.3_Silent_p.K223K			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	223					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		TGAGCTGCTCCTTGCCGTTCA	0.642000													53	101					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70550872	70550872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70550872C>T	ENST00000260128.4	+	20	3137	c.2420C>T	c.(2419-2421)cCt>cTt	p.P807L	SULF1_ENST00000419716.3_Missense_Mutation_p.P807L|SULF1_ENST00000458141.2_Missense_Mutation_p.P807L|SULF1_ENST00000402687.4_Missense_Mutation_p.P807L|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	807					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AATACAGATCCTTATCAGGTA	0.348000													10	107					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87175226	87175226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87175226C>T	ENST00000265724.3	-	16	2257	c.1840G>A	c.(1840-1842)Gaa>Aaa	p.E614K	ABCB1_ENST00000543898.1_Missense_Mutation_p.E550K	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	614	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTCATGAGTTCATCATGATTT	0.383000													29	90					0	0	1	0	0
HLA-DQA1	3117	broad.mit.edu	37	6	32609298	32609298	+	Silent	SNP	C	C	T	rs36219014		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32609298C>T	ENST00000343139.5	+	2	396	c.294C>T	c.(292-294)atC>atT	p.I98I	HLA-DQA1_ENST00000395363.1_Silent_p.I98I|HLA-DQA1_ENST00000374949.2_Silent_p.I98I	NM_002122.3	NP_002113.2	P01909	DQA1_HUMAN	major histocompatibility complex, class II, DQ alpha 1	97	Alpha-1.		L -> M (in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07).|L -> V (in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03).		antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6						ACTTGAACATCATGATTAAAC	0.478000													44	23					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1263213	1263213	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1263213G>A	ENST00000308624.5	+	13	1206	c.1077_splice	c.e13+1	p.K359_splice	SNTG2_ENST00000407292.1_Splice_Site_p.K232_splice	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	359	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		AAGTTCACAAGGTAGGTATCT	0.433000													16	38					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50724778	50724778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:50724778G>A	ENST00000404971.1	-	15	4031	c.2692C>T	c.(2692-2694)Ctt>Ttt	p.L898F	NRXN1_ENST00000402717.3_Missense_Mutation_p.L850F|NRXN1_ENST00000401669.2_Missense_Mutation_p.L858F|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Missense_Mutation_p.L858F|NRXN1_ENST00000405472.3_Missense_Mutation_p.L850F|NRXN1_ENST00000406859.3_Missense_Mutation_p.L858F	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	858					adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACAGAAGAAAGATACCGTCGT	0.408000													22	58					0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26860664	26860664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26860664G>A	ENST00000398145.2	-	11	1548	c.932C>T	c.(931-933)cCc>cTc	p.P311L	HPS4_ENST00000398141.1_Missense_Mutation_p.P324L|HPS4_ENST00000336873.5_Missense_Mutation_p.P311L|HPS4_ENST00000402105.3_Missense_Mutation_p.P306L	NM_022081.4	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	311					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						AGGGGATGTGGGATCTGGGGT	0.577000									Hermansky-Pudlak syndrome				24	78					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34164423	34164423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34164423C>T	ENST00000373381.4	-	24	4031	c.3855G>A	c.(3853-3855)cgG>cgA	p.R1285R	CSMD2_ENST00000373380.1_Silent_p.R158R|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1245	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTCACTACCCCGCAGGCTGT	0.607000													10	105					0	0	1	0	0
MRPL51	51258	broad.mit.edu	37	12	6601615	6601615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6601615G>A	ENST00000229238.3	-	3	670	c.209C>T	c.(208-210)cCc>cTc	p.P70L	MRPL51_ENST00000543164.1_5'UTR|MRPL51_ENST00000543703.1_5'UTR	NM_016497.3	NP_057581.2	Q4U2R6	RM51_HUMAN	mitochondrial ribosomal protein L51	70					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome			kidney(2)|large_intestine(1)|lung(3)	6						CAGTTCTTTGGGGTGCTTTTC	0.443000													98	156					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6866924	6866924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6866924G>A	ENST00000299454.4	+	1	42	c.11G>A	c.(10-12)gGa>gAa	p.G4E	OR10A5_ENST00000379831.2_Missense_Mutation_p.G8E			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATGGCTATAGGAAACTGGACA	0.383000													66	206					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43473424	43473424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43473424G>A	ENST00000532038.1	-	14	1780	c.1645C>T	c.(1645-1647)Ctg>Ttg	p.L549L	ARHGAP27_ENST00000532891.2_Silent_p.L749L|ARHGAP27_ENST00000528384.1_Silent_p.L403L|ARHGAP27_ENST00000442348.1_Silent_p.L744L|ARHGAP27_ENST00000455881.1_Silent_p.L430L|ARHGAP27_ENST00000428638.1_Silent_p.L771L|ARHGAP27_ENST00000376922.2_Silent_p.L430L			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	771	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					AAGAGCTTCAGGGCTCCGGTG	0.632000													6	38					0	0	1	0	0
NTSR1	4923	broad.mit.edu	37	20	61386197	61386197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61386197C>T	ENST00000370501.3	+	2	1246	c.875C>T	c.(874-876)cCt>cTt	p.P292L		NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	292						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			GCCATCGAGCCTGGCAGGGTC	0.687000													12	29					0	0	1	0	0
UBXN11	91544	broad.mit.edu	37	1	26627455	26627455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26627455G>A	ENST00000314675.7	-	4	240	c.161C>T	c.(160-162)tCc>tTc	p.S54F	UBXN11_ENST00000436301.2_Intron|UBXN11_ENST00000374223.1_Intron|UBXN11_ENST00000357089.4_Intron|UBXN11_ENST00000535108.1_Intron|UBXN11_ENST00000374221.3_Missense_Mutation_p.S54F|UBXN11_ENST00000374217.2_Intron|UBXN11_ENST00000374222.1_Missense_Mutation_p.S54F	NM_001077262.1	NP_001070730.1	Q5T124	UBX11_HUMAN	UBX domain protein 11	54						cytoplasm|cytoskeleton				endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						GCCATAGCAGGAAGGGACTGA	0.617000													43	91					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4511239	4511239	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4511239C>T	ENST00000301286.3	-	3	2690	c.2691G>A	c.(2689-2691)ggG>ggA	p.G897G		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	897	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TCTGGACAGTCCCTTTGGCCA	0.602000													32	115					0	0	1	0	0
WNT8A	7478	broad.mit.edu	37	5	137423581	137423581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137423581G>A	ENST00000506684.1	+	3	618	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	WNT8A_ENST00000398754.1_Missense_Mutation_p.E110K			Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family, member 8A	110					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GGGTGACTTCGAAAACTGTGG	0.483000													66	175					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	44913862	44913862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:44913862C>T	ENST00000429094.2	-	19	2830	c.2326G>A	c.(2326-2328)Gaa>Aaa	p.E776K	NELL2_ENST00000395487.2_Missense_Mutation_p.E775K|NELL2_ENST00000333837.4_Missense_Mutation_p.E799K|NELL2_ENST00000551601.1_Missense_Mutation_p.E728K|NELL2_ENST00000549027.1_Missense_Mutation_p.E775K|NELL2_ENST00000452445.2_Missense_Mutation_p.E776K|NELL2_ENST00000437801.2_Missense_Mutation_p.E826K	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	776	VWFC 5.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		ACATTCATTTCGTCCAGGCAA	0.498000													15	60					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926313	1926313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1926313C>T	ENST00000399161.2	-	10	1975	c.1228G>A	c.(1228-1230)Gac>Aac	p.D410N	MYT1L_ENST00000428368.2_Missense_Mutation_p.D410N	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	410					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.D410N(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GTGGTATCGTCGTCCCGCTCA	0.582000													14	53					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20489922	20489922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20489922C>T	ENST00000573854.1	+	10	1318	c.1204C>T	c.(1204-1206)Ctg>Ttg	p.L402L	ACSM2A_ENST00000417235.2_Silent_p.L323L|ACSM2A_ENST00000536134.1_Silent_p.L174L|ACSM2A_ENST00000396104.2_Silent_p.L402L|ACSM2A_ENST00000219054.6_Silent_p.L402L|ACSM2A_ENST00000575690.1_Silent_p.L402L|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	402					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GGGCAACGTCCTGCCCCCCGG	0.502000													8	75					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156810752	156810752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156810752C>T	ENST00000368195.3	-	22	4203	c.3807G>A	c.(3805-3807)cgG>cgA	p.R1269R	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	1269					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCAGGGAGCCCCGGGCCCCCC	0.627000													7	20					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121008394	121008394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121008394G>A	ENST00000392793.1	+	11	3477	c.3206G>A	c.(3205-3207)aGg>aAg	p.R1069K	TECTA_ENST00000264037.2_Missense_Mutation_p.R1069K			O75443	TECTA_HUMAN	tectorin alpha	1069					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACAGACAACAGGGTCCACTGC	0.572000													9	46					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034098	52034098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52034098G>A	ENST00000346477.3	-	3	611	c.543C>T	c.(541-543)tcC>tcT	p.S181S	SIGLEC6_ENST00000391797.3_Silent_p.S170S|SIGLEC6_ENST00000436458.1_Silent_p.S145S|SIGLEC6_ENST00000359982.4_Silent_p.S181S|SIGLEC6_ENST00000343300.4_Silent_p.S181S|SIGLEC6_ENST00000425629.3_Silent_p.S181S	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	181	Ig-like C2-type 1.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CTGACATCCAGGAGAAGATGG	0.652000													34	100					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6312194	6312194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6312194G>A	ENST00000301452.4	-	3	393	c.316C>T	c.(316-318)Cgc>Tgc	p.R106C		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	106						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						AAATAGCAGCGGGGCATCCAT	0.587000													14	46					0	0	1	0	0
FCER2	2208	broad.mit.edu	37	19	7761754	7761754	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7761754C>T	ENST00000346664.5	-	8	638	c.426G>A	c.(424-426)cgG>cgA	p.R142R	FCER2_ENST00000360067.4_Silent_p.R141R|FCER2_ENST00000597921.1_Silent_p.R142R	NM_001220500.1|NM_002002.4	NP_001207429.1|NP_001993.2	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor for (CD23)	142					positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10						TCACCTCCTCCCGGAGTCTTT	0.587000													4	9					0	0	1	0	0
SLC17A4	10050	broad.mit.edu	37	6	25773505	25773505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25773505G>A	ENST00000377905.4	+	7	828	c.709G>A	c.(709-711)Gga>Aga	p.G237R	SLC17A4_ENST00000397076.2_Intron|SLC17A4_ENST00000439485.2_Intron	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	237					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTTCCTAGGAGGAATTGGCTG	0.443000													45	94					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102869434	102869434	+	Silent	SNP	C	C	T	rs147960415	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102869434C>T	ENST00000456098.1	-	2	425	c.207G>A	c.(205-207)agG>agA	p.R69R	IGF1_ENST00000392904.1_Silent_p.R69R|IGF1_ENST00000424202.2_Silent_p.R53R|IGF1_ENST00000307046.8_Silent_p.R69R|IGF1_ENST00000337514.6_Silent_p.R69R	NM_001111283.1	NP_001104753.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	69	B.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						AATAAAAGCCCCTGTCTCCAC	0.547000													15	60					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100190594	100190594	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100190594C>T	ENST00000241071.6	+	5	1069	c.747C>T	c.(745-747)atC>atT	p.I249I	FBXO24_ENST00000468962.1_Silent_p.I237I|FBXO24_ENST00000465843.1_Silent_p.I235I|PCOLCE-AS1_ENST00000544873.1_RNA|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000360609.2_Silent_p.I235I|FBXO24_ENST00000427939.2_Silent_p.I287I	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	249						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TCAAGCAGATCGTGCTGGTTG	0.552000													7	50					0	0	1	0	0
FAM76A	199870	broad.mit.edu	37	1	28081763	28081763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28081763C>T	ENST00000373954.6	+	7	759	c.657C>T	c.(655-657)gcC>gcT	p.A219A	FAM76A_ENST00000373949.1_Silent_p.A190A|FAM76A_ENST00000234549.7_Silent_p.A224A|FAM76A_ENST00000530324.1_Silent_p.A219A|FAM76A_ENST00000010299.6_Silent_p.A253A|FAM76A_ENST00000419687.2_Silent_p.A139A	NM_001143912.1|NM_152660.2	NP_001137384.1|NP_689873.1	Q8TAV0	FA76A_HUMAN	family with sequence similarity 76, member A	219										endometrium(4)|kidney(2)|large_intestine(1)|lung(2)	9		Colorectal(325;0.000147)|all_lung(284;0.00181)|Lung NSC(340;0.00278)|Renal(390;0.00357)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00253)|KIRC - Kidney renal clear cell carcinoma(1967;0.00292)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)		TCATCATTGCCCAACTGAAGG	0.403000													57	129					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182558	140182558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140182558G>A	ENST00000522353.2	+	1	1776	c.1776G>A	c.(1774-1776)gcG>gcA	p.A592A	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Silent_p.A592A|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTGGTAGCGAAGGTGCGCG	0.687000													30	93					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762896	24762896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24762896G>A	ENST00000376451.2	+	2	1000	c.740G>A	c.(739-741)gGa>gAa	p.G247E	KIAA1217_ENST00000307544.6_Missense_Mutation_p.G247E|KIAA1217_ENST00000376452.3_Missense_Mutation_p.G529E|KIAA1217_ENST00000458595.1_Missense_Mutation_p.G529E|KIAA1217_ENST00000376462.1_Missense_Mutation_p.G449E|KIAA1217_ENST00000430453.2_Missense_Mutation_p.G450E|KIAA1217_ENST00000376454.3_Missense_Mutation_p.G529E|KIAA1217_ENST00000396445.1_Missense_Mutation_p.G247E|KIAA1217_ENST00000396446.1_Missense_Mutation_p.G247E			Q5T5P2	SKT_HUMAN	KIAA1217	529					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AGCGCTGCAGGATTATCCAGC	0.552000													22	75					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80615938	80615938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80615938C>T	ENST00000458043.2	+	6	381	c.375C>T	c.(373-375)ttC>ttT	p.F125F	OTOGL_ENST00000547103.1_Silent_p.F125F	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTGAAACATTCGATGGCATCT	0.413000													24	75					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424593	56424593	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56424593C>T	ENST00000588751.1	-	5	614	c.590G>A	c.(589-591)tGg>tAg	p.W197*	NLRP13_ENST00000342929.3_Nonsense_Mutation_p.W197*			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	197							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTCTTTAGGCCAACTGATGTT	0.488000													12	168					0	0	1	0	0
IFIT1B	439996	broad.mit.edu	37	10	91143629	91143629	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:91143629C>T	ENST00000371809.3	+	2	639	c.559C>T	c.(559-561)Cgc>Tgc	p.R187C	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	187							binding			endometrium(2)|large_intestine(3)|lung(8)	13						CACCGTCTATCGCCTGGATAA	0.438000													110	229					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42546860	42546860	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42546860C>T	ENST00000262895.3	-	11	1316	c.1317G>A	c.(1315-1317)ggG>ggA	p.G439G	GRIK5_ENST00000301218.4_Silent_p.G439G|GRIK5_ENST00000593562.1_Silent_p.G439G	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	439						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	AGCGTTCGTTCCCCGACAGGG	0.652000													16	33					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230456299	230456299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230456299C>T	ENST00000341772.4	-	2	716	c.582G>A	c.(580-582)gtG>gtA	p.V194V		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	194					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TTCTCACCTCCACTTGATCCC	0.428000													14	38					0	0	1	0	0
SPACA1	81833	broad.mit.edu	37	6	88757792	88757792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88757792G>A	ENST00000237201.1	+	1	286	c.169G>A	c.(169-171)Gag>Aag	p.E57K		NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	57						integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		CAACGACAGCGAGACCGCGGA	0.692000													8	3					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79674064	79674064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79674064C>T	ENST00000571730.1	+	4	605	c.474C>T	c.(472-474)ctC>ctT	p.L158L	MRPL12_ENST00000333676.3_Silent_p.L158L|SLC25A10_ENST00000541223.1_Silent_p.L158L			Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	GCATCAACCTCGTCCAGGTCT	0.582000													20	43					0	0	1	0	0
TNFRSF17	608	broad.mit.edu	37	16	12060155	12060155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:12060155G>A	ENST00000053243.1	+	2	452	c.234G>A	c.(232-234)agG>agA	p.R78R	TNFRSF17_ENST00000396495.3_Intron|RP11-166B2.1_ENST00000532936.1_Intron	NM_001192.2	NP_001183.2	Q02223	TNR17_HUMAN	tumor necrosis factor receptor superfamily, member 17	78					cell proliferation|multicellular organismal development	endomembrane system|integral to membrane|plasma membrane				large_intestine(3)|lung(3)	6						TTTTGCTAAGGAAGATAAACT	0.383000			T	IL2	intestinal T-cell lymphoma								29	92					0	0	1	0	0
ASB11	140456	broad.mit.edu	37	X	15307707	15307707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:15307707C>T	ENST00000537676.1	-	5	583	c.511G>A	c.(511-513)Gag>Aag	p.E171K	ASB11_ENST00000480796.1_Missense_Mutation_p.E192K|ASB11_ENST00000344384.4_Missense_Mutation_p.E171K|ASB11_ENST00000380470.3_Missense_Mutation_p.E175K			Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box containing 11	192					intracellular signal transduction					breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(1)	16	Hepatocellular(33;0.183)					TGAGGCACCTCATGGTCAATG	0.433000													100	74					0	0	1	0	0
POTED	317754	broad.mit.edu	37	21	14982958	14982958	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:14982958C>T	ENST00000299443.5	+	1	461	c.409C>T	c.(409-411)Cga>Tga	p.R137*		NM_174981.3|NM_207355.2	NP_778146.2|NP_997238.2	Q86YR6	POTED_HUMAN	POTE ankyrin domain family, member D	137						plasma membrane				central_nervous_system(1)|large_intestine(10)|liver(2)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	33						CCACATCCGTCGAGAAGATCT	0.587000													7	56					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20683155	20683155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20683155C>T	ENST00000404938.2	+	7	1230	c.578C>T	c.(577-579)tCg>tTg	p.S193L		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	379					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity	p.S193L(1)|p.S193*(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TCTACTTTTTCGATTGGCCTG	0.423000													28	112					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31322961	31322961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31322961G>A	ENST00000265071.2	+	12	2184	c.1919G>A	c.(1918-1920)cGa>cAa	p.R640Q		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	640					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.R640Q(1)		NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AGGCGGCAGCGAAAAAAAGAG	0.453000													30	63					0	0	1	0	0
VIPR1	7433	broad.mit.edu	37	3	42577678	42577678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42577678G>A	ENST00000433647.1	+	14	1780	c.1156G>A	c.(1156-1158)Ggc>Agc	p.G386S	VIPR1_ENST00000543411.1_Missense_Mutation_p.G379S|VIPR1_ENST00000438259.2_Missense_Mutation_p.G217S|VIPR1_ENST00000325123.4_Missense_Mutation_p.G427S	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	427					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		AGGCAGCAACGGCGCCACGTG	0.692000													3	13					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344279	56344279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56344279C>T	ENST00000526812.2	-	1	984	c.919G>A	c.(919-921)Gga>Aga	p.G307R		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						AAGGATTTTCCCCTAATCATT	0.373000													74	197					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113857486	113857486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113857486G>A	ENST00000355556.2	+	7	1203	c.970G>A	c.(970-972)Gag>Aag	p.E324K	HTR3A_ENST00000535865.1_Intron|HTR3A_ENST00000506841.2_Missense_Mutation_p.E318K|HTR3A_ENST00000504030.2_Intron|HTR3A_ENST00000299961.5_Intron|HTR3A_ENST00000375498.2_Intron	NM_213621.3	NP_998786.2	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	305					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TCAGTCTGGTGAGAAACCCGC	0.597000													26	137					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374056	31374056	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31374056C>T	ENST00000268296.4	+	12	1462	c.1341C>T	c.(1339-1341)gcC>gcT	p.A447A	ITGAX_ENST00000562522.1_Silent_p.A447A	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	447					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GGATGAAGGCCGAAGTCACGG	0.652000													12	35					0	0	1	0	0
TTC24	164118	broad.mit.edu	37	1	156555535	156555535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156555535C>T	ENST00000368236.3	+	9	1523	c.1487C>T	c.(1486-1488)tCg>tTg	p.S496L	TTC24_ENST00000368237.3_Missense_Mutation_p.S496L|TTC24_ENST00000495690.1_3'UTR	NM_001105669.2	NP_001099139.2	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	496							binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	20	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGAATCATTCGCACCATCTA	0.512000													35	84					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28436193	28436193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28436193G>A	ENST00000261609.7	-	55	8675	c.8567C>T	c.(8566-8568)tCc>tTc	p.S2856F		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2856	DOC.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTTATTCAGGGAATTTCCACC	0.368000													11	45					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3659212	3659212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:3659212C>T	ENST00000382622.3	+	3	762	c.372C>T	c.(370-372)atC>atT	p.I124I	PRMT8_ENST00000261252.4_3'UTR|PRMT8_ENST00000452611.2_Silent_p.I115I	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	124					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			GTACTGGGATCCTTTCCATGT	0.572000													49	91					0	0	1	0	0
RAB3B	5865	broad.mit.edu	37	1	52442595	52442595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:52442595G>A	ENST00000371655.3	-	2	407	c.195C>T	c.(193-195)taC>taT	p.Y65Y		NM_002867.3	NP_002858.2	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	65					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9						TCTCGTGACGGTAGACTGTCT	0.562000													26	59					0	0	1	0	0
SAPCD2	89958	broad.mit.edu	37	9	139960772	139960772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139960772G>A	ENST00000409687.3	-	2	753	c.626C>T	c.(625-627)cCc>cTc	p.P209L		NM_178448.3	NP_848543.2	Q86UD0	CI140_HUMAN	suppressor APC domain containing 2	209						cytoplasm|nucleus											TCGGGCACGGGGAGCCCGCCG	0.701000													4	19					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	21698984	21698984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:21698984G>A	ENST00000382148.3	-	1	413	c.77C>T	c.(76-78)tCt>tTt	p.S26F	KCNIP4_ENST00000382152.2_Intron|KCNIP4_ENST00000447367.2_Intron	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	0	KIS (By similarity).					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				TGTATGAAGAGAACCTGTTAA	0.348000													23	69					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160109743	160109743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160109743C>T	ENST00000361216.3	+	22	3092	c.3003C>T	c.(3001-3003)gtC>gtT	p.V1001V	ATP1A2_ENST00000392233.3_Silent_p.V990V	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1001					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			ATGATGAGGTCCGAAAGCTCA	0.577000													29	124					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906819	13906819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13906819G>A	ENST00000279593.3	-	3	651	c.442C>T	c.(442-444)Cca>Tca	p.P148S		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	148					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCAATTGATGGGCCAAACTGG	0.398000													5	45					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159170712	159170712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159170712G>A	ENST00000368125.4	+	9	1354	c.1197G>A	c.(1195-1197)taG>taA	p.*399*	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000497636.1_3'UTR|CADM3_ENST00000368124.4_Silent_p.*433*	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	0					adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					ATTTCATCTAGAGGCGCCTGC	0.642000													7	63					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95085787	95085787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95085787G>A	ENST00000553947.1	+	6	1862	c.974G>A	c.(973-975)aGa>aAa	p.R325K	SERPINA3_ENST00000467132.1_Missense_Mutation_p.R300K|SERPINA3_ENST00000393080.4_Missense_Mutation_p.R300K|SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000482740.1_Missense_Mutation_p.R82K|SERPINA3_ENST00000393078.3_Missense_Mutation_p.R300K			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	300					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		AAGCGGTGGAGAGACTCTCTG	0.557000													11	47					0	0	1	0	0
LRRC43	254050	broad.mit.edu	37	12	122677421	122677421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122677421G>A	ENST00000339777.4	+	7	1247	c.1219G>A	c.(1219-1221)Gag>Aag	p.E407K	LRRC43_ENST00000425921.1_Missense_Mutation_p.E222K	NM_152759.4	NP_689972.3	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43	407	Glu-rich.									NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		GTCTGAGGTGGAGGAGTCAGG	0.547000													20	42					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10448673	10448673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10448673G>A	ENST00000245503.5	-	5	879	c.495C>T	c.(493-495)ttC>ttT	p.F165F	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Silent_p.F165F|MYH2_ENST00000532183.1_Silent_p.F165F	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	165	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CAGTCAGCATGAACTGATAGG	0.527000													79	183					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52130793	52130793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52130793G>A	ENST00000222107.4	-	6	1342	c.1204C>T	c.(1204-1206)Ctc>Ttc	p.L402F	SIGLEC5_ENST00000599649.1_Missense_Mutation_p.L402F|SIGLEC5_ENST00000429354.3_Missense_Mutation_p.L402F|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.L402F|SIGLEC5_ENST00000534261.2_Missense_Mutation_p.L402F			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	402					cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TCGGAGCTGAGCCCCCCGTGG	0.632000													17	81					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10409243	10409243	+	Missense_Mutation	SNP	G	G	A	rs142560385	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10409243G>A	ENST00000226207.5	-	19	2154	c.2060C>T	c.(2059-2061)gCc>gTc	p.A687V	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	687	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						ATGCTCCATGGCACCTAAAAG	0.473000													7	54					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4222756	4222756	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4222756C>T	ENST00000600132.1	+	20	3537	c.3261C>T	c.(3259-3261)ctC>ctT	p.L1087L	ANKRD24_ENST00000262970.5_Silent_p.L1177L|ANKRD24_ENST00000318934.4_Silent_p.L1087L	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1087										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TGGAGGCTCTCCGTGACCAGG	0.572000													8	18					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60165033	60165033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:60165033G>A	ENST00000261187.4	+	3	415	c.251G>A	c.(250-252)gGc>gAc	p.G84D	SLC16A7_ENST00000543448.1_5'UTR|SLC16A7_ENST00000552024.1_Missense_Mutation_p.G84D|SLC16A7_ENST00000547379.1_Missense_Mutation_p.G84D|SLC16A7_ENST00000552432.1_Missense_Mutation_p.G84D	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	84						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	AATAAATACGGCAGCCGGCCG	0.443000													28	188					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8808219	8808219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8808219C>T	ENST00000324436.3	-	1	953	c.833G>A	c.(832-834)cGg>cAg	p.R278Q		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	278						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						CTTCAGAGTCCGCTTGTACTC	0.627000													15	46					0	0	1	0	0
OOEP	441161	broad.mit.edu	37	6	74079371	74079371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:74079371G>A	ENST00000370359.5	-	1	144	c.145C>T	c.(145-147)Cct>Tct	p.P49S	OOEP_ENST00000370363.1_Intron	NM_001080507.2	NP_001073976.1	A6NGQ2	OOEP_HUMAN	oocyte expressed protein	49	KH; atypical.					cytoplasm				large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	8						AACACCAAAGGGTCTCTCAGT	0.612000													14	103					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6748162	6748162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6748162G>A	ENST00000229243.2	-	9	1560	c.1467C>T	c.(1465-1467)tcC>tcT	p.S489S	ACRBP_ENST00000542357.1_5'UTR|ACRBP_ENST00000414226.2_Silent_p.S456S	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	489						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						GGCTTTTGAAGGAACAGTAGT	0.532000													9	97					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52353881	52353881	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52353881C>T	ENST00000296585.5	+	10	1266	c.1123C>T	c.(1123-1125)Cag>Tag	p.Q375*		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	375					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AGACAACTTTCAGATGGAAAT	0.363000													21	69					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33956124	33956124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33956124G>A	ENST00000379238.1	-	11	936	c.819C>T	c.(817-819)ttC>ttT	p.F273F	UBAP2_ENST00000539807.1_Silent_p.F28F|UBAP2_ENST00000418786.2_Silent_p.F220F|UBAP2_ENST00000449054.1_Silent_p.F273F|UBAP2_ENST00000379239.4_Intron|UBAP2_ENST00000360802.1_Silent_p.F273F			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	273										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		ATGAGGCAGTGAAGACCTTTG	0.348000													15	84					0	0	1	0	0
MTAP	4507	broad.mit.edu	37	9	21859391	21859391	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21859391C>T	ENST00000380172.4	+	7	986	c.780C>T	c.(778-780)tcC>tcT	p.S260S	RP11-145E5.5_ENST00000404796.2_Intron|MTAP_ENST00000580900.1_Silent_p.S260S|RP11-70L8.4_ENST00000581788.1_RNA|MTAP_ENST00000460874.2_Silent_p.S277S	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	260					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	AGATAGGGTCCACAGAATGGT	0.443000													11	32					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944846	43944846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43944846C>T	ENST00000389420.3	-	2	318	c.319G>A	c.(319-321)Gtg>Atg	p.V107M	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.V107M	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	107						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCCAAGTGCACCTCGGTGTAG	0.662000													7	35					0	0	1	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148715266	148715266	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148715266G>C	ENST00000296721.4	+	18	2362	c.2264G>C	c.(2263-2265)aGg>aCg	p.R755T	AFAP1L1_ENST00000515000.1_Intron	NM_001146337.1|NM_152406.2	NP_001139809.1|NP_689619.1	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	755							protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCAAGGAAGGGTGCTACAG	0.488000													39	112					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36215909	36215909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36215909C>T	ENST00000420124.1	+	10	3449	c.3449C>T	c.(3448-3450)cCc>cTc	p.P1150L	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Missense_Mutation_p.P1150L																							GCCCCTGGCCCCTTTGCTTCT	0.592000													29	41					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68650889	68650889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68650889C>T	ENST00000423218.2	-	6	602	c.507G>A	c.(505-507)ctG>ctA	p.L169L	ITGA11_ENST00000315757.7_Silent_p.L169L|ITGA11_ENST00000562826.1_5'UTR			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	169	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	TGGAGCCATCCAGGACAATGA	0.527000													24	31					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323157	61323157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61323157C>T	ENST00000283752.5	-	8	1050	c.907G>A	c.(907-909)Gga>Aga	p.G303R	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.G251R	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	303					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						TCCACCATTCCCATGGTTCTC	0.507000													25	123					0	0	1	0	0
OR3A2	4995	broad.mit.edu	37	17	3181574	3181574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3181574G>A	ENST00000408891.2	-	1	694	c.656C>T	c.(655-657)cCt>cTt	p.P219L		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	219					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GAGAACCAAAGGTGTGCCTGC	0.557000													11	53					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887759	47887759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47887759G>A	ENST00000396105.1	-	3	836	c.590C>T	c.(589-591)tCc>tTc	p.S197F	ZNFX1_ENST00000371754.4_Missense_Mutation_p.S197F|ZNFX1_ENST00000371752.1_Missense_Mutation_p.S197F	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	197							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ATCCATTTTGGAGCTACAAGC	0.448000													39	118					0	0	1	0	0
ISOC1	51015	broad.mit.edu	37	5	128440889	128440889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128440889C>T	ENST00000173527.5	+	3	457	c.441C>T	c.(439-441)gcC>gcT	p.A147A		NM_016048.2	NP_057132.2	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	147						peroxisome	catalytic activity			kidney(2)|lung(7)	9		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		TGCAAGGGGCCCGGATTTTAG	0.343000													15	73					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92624013	92624013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92624013G>A	ENST00000298047.6	+	27	13521	c.13504G>A	c.(13504-13506)Gaa>Aaa	p.E4502K	FAT3_ENST00000525166.1_Missense_Mutation_p.E4352K|FAT3_ENST00000533797.1_Missense_Mutation_p.E805K|FAT3_ENST00000489716.1_3'UTR|FAT3_ENST00000409404.2_Missense_Mutation_p.E4470K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4502	Pro-rich.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTCCCCAACGAAACGGATTT	0.592000										TCGA Ovarian(4;0.039)			18	41					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111398117	111398117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111398117G>A	ENST00000265162.5	+	1	889	c.547G>A	c.(547-549)Gat>Aat	p.D183N		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	183					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CAGCAGTGGAGATGGCCTGTA	0.572000													40	93					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752368	62752368	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:62752368C>T	ENST00000331425.6	-	0	1067					NR_003952.1																						TAGTAAGGTTCGAGGATAAGC	0.428000													9	24					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52548200	52548200	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52548200C>T	ENST00000321725.6	+	33	3593	c.3517C>T	c.(3517-3519)Ctg>Ttg	p.L1173L		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1173	FAS1 4.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CAACCGCTCCCTGGAGGCCCA	0.642000													18	68					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50405665	50405665	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50405665C>T	ENST00000435965.1	-	25	2241	c.2066_splice	c.e25-1	p.E690_splice	CACNA2D2_ENST00000423994.2_Splice_Site_p.E690_splice|CACNA2D2_ENST00000266039.3_Splice_Site_p.E683_splice|CACNA2D2_ENST00000479441.1_Splice_Site_p.E690_splice|CACNA2D2_ENST00000424201.2_Splice_Site_p.E683_splice|CACNA2D2_ENST00000360963.3_Splice_Site_p.E614_splice|CACNA2D2_ENST00000395083.1_Splice_Site_p.E683_splice|CACNA2D2_ENST00000429770.1_Splice_Site_p.E683_splice			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	690					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TTGCAGTACTCTCTAGGGATG	0.537000													52	134					0	0	1	0	0
ENTHD2	146705	broad.mit.edu	37	17	79203038	79203038	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79203038G>A	ENST00000374769.2	-	13	1493	c.1016C>T	c.(1015-1017)tCc>tTc	p.S339F	ENTHD2_ENST00000300714.3_Missense_Mutation_p.S423F|AC027601.1_ENST00000575922.1_RNA					ENTH domain containing 2																		TGGAATGGGGGAGGCATCTGG	0.687000													8	8					0	0	1	0	0
C9orf135	138255	broad.mit.edu	37	9	72471531	72471531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72471531G>A	ENST00000377197.3	+	3	409	c.322G>A	c.(322-324)Gaa>Aaa	p.E108K	C9orf135_ENST00000466872.2_3'UTR|C9orf135_ENST00000527647.1_Missense_Mutation_p.E108K	NM_001010940.1	NP_001010940.1	Q5VTT2	CI135_HUMAN	chromosome 9 open reading frame 135	108						integral to membrane				endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						AGAATGGGTTGAAATGAAGAG	0.338000													24	58					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69348988	69348988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:69348988G>A	ENST00000260364.5	+	17	2497	c.2196G>A	c.(2194-2196)aaG>aaA	p.K732K	NOX5_ENST00000448182.3_Silent_p.K704K|NOX5_ENST00000530406.2_Silent_p.K722K|NOX5_ENST00000455873.3_Silent_p.K715K|NOX5_ENST00000388866.3_Silent_p.K750K			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	750					angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						AGGTGCTGAAGGGCCATTGTG	0.537000													58	66					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196689128	196689128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196689128C>T	ENST00000312428.6	-	49	9242	c.9142G>A	c.(9142-9144)Gaa>Aaa	p.E3048K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3048	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGAAGAGGTTCCAAAATAGGA	0.353000													30	119					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43503703	43503703	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43503703G>A	ENST00000300215.3	-	4	1007	c.550C>T	c.(550-552)Cag>Tag	p.Q184*	EPB42_ENST00000441366.2_Nonsense_Mutation_p.Q154*|EPB42_ENST00000540029.1_Nonsense_Mutation_p.Q76*			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	154					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		TCCATGCGCTGAGCCTCATTC	0.582000													30	89					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29284912	29284912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29284912G>A	ENST00000266943.6	-	4	1498	c.1129C>T	c.(1129-1131)Cgt>Tgt	p.R377C	SLC46A3_ENST00000380814.4_Missense_Mutation_p.R377C	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	377					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		TCAGTCGAACGAACCACTTTT	0.388000													31	95					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795591	142795591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142795591C>T	ENST00000370498.1	-	2	840	c.87G>A	c.(85-87)gaG>gaA	p.E29E		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	29										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGTTCGGTGCCTCCTGCATCT	0.418000													20	21					0	0	1	0	0
HSFY1P1	27437	broad.mit.edu	37	22	17308721	17308721	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17308721C>T	ENST00000425038.1	+	0	358					NR_003607.1																						CAATTCAAGTCTAATTCATAG	0.318000													7	24					0	0	1	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940217	67940217	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:67940217G>A	ENST00000357461.2	-	3	833	c.424C>T	c.(424-426)Ctc>Ttc	p.L142F	TMEM229B_ENST00000557006.1_Missense_Mutation_p.L142F	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	142						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						TCGAAGCGGAGGCGGAGGGTG	0.657000													16	41					0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38183162	38183162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38183162G>A	ENST00000394126.1	-	16	2149	c.1731C>T	c.(1729-1731)acC>acT	p.T577T	MED24_ENST00000501516.3_Silent_p.T571T|MED24_ENST00000394127.2_Silent_p.T539T|MED24_ENST00000394128.2_Silent_p.T552T|MED24_ENST00000356271.3_Silent_p.T539T			O75448	MED24_HUMAN	mediator complex subunit 24	552					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					ACTCCACTTTGGTGGAGTCGG	0.642000											OREG0024386	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	11					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733414	50733414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50733414C>T	ENST00000300589.2	+	2	194	c.89C>T	c.(88-90)tCg>tTg	p.S30L	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	30	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GAAATGTGCTCGCAGGAGGCT	0.612000													88	166					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386727	56386727	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56386727G>A	ENST00000355701.3	-	22	4776	c.3906C>T	c.(3904-3906)ccC>ccT	p.P1302P	BZRAP1_ENST00000268893.6_Silent_p.P1242P|BZRAP1_ENST00000343736.4_Silent_p.P1302P	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1302						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCTCACAAAAGGGGTCGGGCT	0.587000													16	39					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122805572	122805572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:122805572C>T	ENST00000227349.2	+	5	1720	c.1423C>T	c.(1423-1425)Caa>Taa	p.Q475*	C11orf63_ENST00000531316.1_Nonsense_Mutation_p.Q475*	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	475										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		ACACAAAGACCAAGAAGAGAA	0.398000													49	138					0	0	1	0	0
DMRTC2	63946	broad.mit.edu	37	19	42351874	42351874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42351874C>T	ENST00000269945.3	+	3	346	c.295C>T	c.(295-297)Ctg>Ttg	p.L99L	DMRTC2_ENST00000596827.1_Silent_p.L99L|DMRTC2_ENST00000602098.1_3'UTR	NM_001040283.1	NP_001035373.1	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	99					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						AAAGAAGCACCTGATGAGGAG	0.597000													6	10					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84270552	84270552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84270552C>T	ENST00000568181.1	-	2	660	c.540G>A	c.(538-540)agG>agA	p.R180R	KCNG4_ENST00000308251.4_Silent_p.R180R			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	180						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GTACGTCCTCCCTGTGCAGCT	0.677000													14	29					0	0	1	0	0
MAP2K5	5607	broad.mit.edu	37	15	67995676	67995676	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:67995676C>T	ENST00000178640.5	+	16	1601	c.972_splice	c.e16-1	p.P325_splice	MAP2K5_ENST00000354498.5_Splice_Site_p.P289_splice|MAP2K5_ENST00000395476.2_Splice_Site_p.P325_splice|MAP2K5_ENST00000340972.4_Splice_Site_p.P135_splice	NM_145160.2	NP_660143.1	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	325	Protein kinase.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|skin(1)	16						TTCTTGCAGCCTGAAAGGATT	0.463000													35	85					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100191794	100191794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100191794C>T	ENST00000554176.1	+	8	1420	c.754C>T	c.(754-756)Cgc>Tgc	p.R252C	CYP46A1_ENST00000423126.2_Missense_Mutation_p.R318C|CYP46A1_ENST00000261835.3_Missense_Mutation_p.R415C			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	415					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CAACCCCGATCGCTTCGGCCC	0.612000													11	54					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37067192	37067192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37067192C>T	ENST00000231790.2	+	12	1319	c.1103C>T	c.(1102-1104)tCg>tTg	p.S368L	MLH1_ENST00000458205.2_Missense_Mutation_p.S127L|MLH1_ENST00000455445.2_Missense_Mutation_p.S127L|MLH1_ENST00000435176.1_Missense_Mutation_p.S270L|MLH1_ENST00000536378.1_Missense_Mutation_p.S127L|MLH1_ENST00000539477.1_Missense_Mutation_p.S127L	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	368					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						AGTCTGACCTCGTCTTCTACT	0.423000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				43	68					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56058286	56058286	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56058286A>C	ENST00000313022.2	-	1	280	c.253T>G	c.(253-255)Tta>Gta	p.L85V		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					GAAGTCAGTAAGTTCGCTAAG	0.418000													134	346					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119652620	119652620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119652620G>A	ENST00000379735.5	-	21	2993	c.2722C>T	c.(2722-2724)Cgt>Tgt	p.R908C	SEC24D_ENST00000429811.2_3'UTR|SEC24D_ENST00000280551.6_Missense_Mutation_p.R907C|SEC24D_ENST00000511481.1_Missense_Mutation_p.R538C|SEC24D_ENST00000505134.1_5'UTR	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	907					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding	p.R907C(1)		breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						TCAGAGCAACGAACGGCAGCA	0.483000													45	98					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52361784	52361784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52361784C>T	ENST00000296585.5	+	15	2063	c.1920C>T	c.(1918-1920)gcC>gcT	p.A640A		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	640					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CTATTGGTGCCTTTGGACAAG	0.458000													38	98					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49411662	49411662	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49411662G>C	ENST00000299191.3	+	2	288	c.171G>C	c.(169-171)gtG>gtC	p.V57V		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	57										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						CCAAAGTGGTGACAGTCCTTA	0.552000													7	12					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427392	119427392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119427392G>A	ENST00000369429.3	-	8	1781	c.1772C>T	c.(1771-1773)cCa>cTa	p.P591L	TBX15_ENST00000207157.3_Missense_Mutation_p.P485L			Q96SF7	TBX15_HUMAN	T-box 15	591						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.P485L(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GGAGGAGCCTGGAACTGCCCC	0.557000													28	88					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69046395	69046395	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69046395G>T	ENST00000295381.3	+	9	1560	c.1141G>T	c.(1141-1143)Ggc>Tgc	p.G381C	ARHGAP25_ENST00000497079.1_Missense_Mutation_p.G375C|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.G75C|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.G342C|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.G375C|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.G374C|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.G382C	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	381					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						AAGCTCTGTAGGCTGGGATGC	0.522000													28	120					8.16721e-17	8.21195e-17	1	1	0
LINC00639	283547	broad.mit.edu	37	14	39304870	39304870	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:39304870G>A	ENST00000553932.1	-	0	3692																											TAATGGAGGTGGATCTTTAAG	0.488000													11	21					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49686399	49686399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49686399C>T	ENST00000252826.5	+	12	1799	c.1673C>T	c.(1672-1674)cCc>cTc	p.P558L	TRPM4_ENST00000427978.2_Missense_Mutation_p.P558L|TRPM4_ENST00000355712.5_Missense_Mutation_p.P204L	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	558					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGGCAGGCCCCCTGGAGCGAC	0.627000													20	41					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116757239	116757239	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116757239C>T	ENST00000331677.3	+	7	2052	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	DSE_ENST00000537543.1_Silent_p.F555F|DSE_ENST00000452085.3_Silent_p.F536F|DSE_ENST00000359564.2_Silent_p.F536F			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	536					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		GGGTGGTTTTCATCCGAGGAG	0.493000													18	26					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23305332	23305332	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:23305332G>A	ENST00000358689.4	-	4	508	c.273C>T	c.(271-273)atC>atT	p.I91I	ENTPD4_ENST00000417069.2_Silent_p.I91I|ENTPD4_ENST00000356206.6_Silent_p.I91I	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	91					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		AGTCCACCACGATCCCATAGT	0.458000													30	106					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37744643	37744643	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37744643G>A	ENST00000539465.1	+	16	3207	c.2614G>A	c.(2614-2616)Gag>Aag	p.E872K	FRMPD1_ENST00000377765.3_Missense_Mutation_p.E872K|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	872						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CTATGACAGGGAGCCCTACCT	0.592000													16	43					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81110910	81110910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81110910C>T	ENST00000228644.3	+	1	220	c.68C>T	c.(67-69)tCc>tTc	p.S23F		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	23					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						TGCATACCGTCCCCCGAGGGT	0.617000													14	41					0	0	1	0	0
IARS2	55699	broad.mit.edu	37	1	220267642	220267642	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:220267642C>T	ENST00000302637.5	+	1	188	c.84C>T	c.(82-84)ccC>ccT	p.P28P	IARS2_ENST00000366922.1_5'UTR	NM_018060.3	NP_060530.3	Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	28					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	CCCGCCTTCCCTGCAGCCCGG	0.711000													6	30					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539788	55539788	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55539788C>T	ENST00000220676.1	+	4	3494	c.3346C>T	c.(3346-3348)Ccc>Tcc	p.P1116S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1116					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGCAGGTGTTCCCTTTCATTC	0.423000													19	58					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99182197	99182197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99182197C>T	ENST00000074304.5	+	21	2655	c.2262C>T	c.(2260-2262)tcC>tcT	p.S754S	INPP4A_ENST00000409463.1_Silent_p.S83S|INPP4A_ENST00000409016.3_Silent_p.S715S|INPP4A_ENST00000545415.1_Silent_p.S715S|INPP4A_ENST00000409540.3_Silent_p.S715S|INPP4A_ENST00000409851.3_Silent_p.S749S|INPP4A_ENST00000523221.1_Silent_p.S754S	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	754					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						CCAGCGCCTCCGCAGACATGC	0.517000													7	85					0	0	1	0	0
PHC3	80012	broad.mit.edu	37	3	169863233	169863233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169863233G>A	ENST00000494943.1	-	6	682	c.614C>T	c.(613-615)tCc>tTc	p.S205F	PHC3_ENST00000467570.1_Missense_Mutation_p.S164F|PHC3_ENST00000495893.1_Missense_Mutation_p.S217F			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	205	Ser-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			AGACTGACAGGAAGATGACGA	0.433000													13	50					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55081805	55081805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55081805C>T	ENST00000302250.2	-	3	463	c.303G>A	c.(301-303)ggG>ggA	p.G101G	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Silent_p.G101G	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	101						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTGTGCCGAGCCCTTCTACAT	0.512000													10	75					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332299	70332299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70332299G>A	ENST00000338508.4	-	32	4101	c.4102C>T	c.(4102-4104)Ccc>Tcc	p.P1368S	SHANK2_ENST00000423696.2_Missense_Mutation_p.P988S|SHANK2_ENST00000409161.1_Missense_Mutation_p.P771S|SHANK2_ENST00000449833.2_Missense_Mutation_p.P772S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	988					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACGGTGGTGGGCTCGGGGGCA	0.627000													20	30					0	0	1	0	0
SGCG	6445	broad.mit.edu	37	13	23894882	23894882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:23894882C>T	ENST00000218867.3	+	7	809	c.685C>T	c.(685-687)Cat>Tat	p.H229Y	SGCG_ENST00000537476.1_Missense_Mutation_p.H229Y|SGCG_ENST00000545013.1_Missense_Mutation_p.H229Y	NM_000231.2	NP_000222.1	Q13326	SGCG_HUMAN	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	229					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		TATTCTTTTTCATAGTAGTGA	0.438000													14	33					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110754499	110754499	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110754499C>T	ENST00000369787.3	+	1	405	c.378C>T	c.(376-378)ttC>ttT	p.F126F	KCNC4_ENST00000438661.2_Silent_p.F126F|KCNC4_ENST00000413138.3_Silent_p.F126F	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	126					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGCCGCTCTTCGAAGAGGAGC	0.657000													6	57					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9106080	9106080	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9106080C>T	ENST00000383836.3	-	5	1099	c.672_splice	c.e5+1	p.K224_splice	SRGAP3_ENST00000433332.3_5'UTR|SRGAP3_ENST00000360413.3_Splice_Site_p.K224_splice	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	224					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCCCACTCACCTTCTCCTTCA	0.607000			T	RAF1	pilocytic astrocytoma								26	69					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27389935	27389935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:27389935G>A	ENST00000379214.4	-	18	2778	c.2335C>T	c.(2335-2337)Ccc>Tcc	p.P779S	LGR4_ENST00000389858.4_Missense_Mutation_p.P755S	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	779						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						ATTATTTCGGGGCTGATAGAG	0.403000													30	105					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51921502	51921502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51921502C>T	ENST00000371117.3	-	18	1962	c.1687G>A	c.(1687-1689)Gaa>Aaa	p.E563K	PKHD1_ENST00000340994.4_Missense_Mutation_p.E563K	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	563					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GCACCTCGTTCAAATCCAAGC	0.403000													34	97					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30954258	30954258	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:30954258G>A	ENST00000295055.8	-	21	2111	c.1935C>T	c.(1933-1935)ttC>ttT	p.F645F	CAPN13_ENST00000534090.2_Silent_p.F645F	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	645	EF-hand 2.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AGAGGTTGCGGAAGGTCTCTA	0.567000													8	10					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3633209	3633209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3633209G>A	ENST00000294008.3	-	14	5682	c.5042C>T	c.(5041-5043)tCg>tTg	p.S1681L	RP11-461A8.1_ENST00000573982.1_lincRNA	NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1681	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CTTGGTGGGCGACCTGCTTGG	0.602000								Direct reversal of damage					37	59					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8608525	8608525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8608525G>A	ENST00000382480.2	+	6	1357	c.557G>A	c.(556-558)cGa>cAa	p.R186Q	CPZ_ENST00000360986.4_Missense_Mutation_p.R323Q|CPZ_ENST00000429646.2_5'UTR|CPZ_ENST00000315782.6_Missense_Mutation_p.R312Q	NM_001014448.2	NP_001014448.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	323					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATCTGAACCGAAATTTCCCG	0.647000													25	53					0	0	1	0	0
PRKAR1B	5575	broad.mit.edu	37	7	751015	751015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:751015G>A	ENST00000406797.1	-	2	302	c.128C>T	c.(127-129)cCc>cTc	p.P43L	PRKAR1B_ENST00000488474.1_5'UTR|PRKAR1B_ENST00000360274.4_Missense_Mutation_p.P43L|PRKAR1B_ENST00000537384.1_Missense_Mutation_p.P43L|PRKAR1B_ENST00000403562.1_Missense_Mutation_p.P43L|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.P43L	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	43	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		GGGGCGTTCGGGCTTGGAGAT	0.632000													20	61					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92590422	92590422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92590422C>T	ENST00000298047.6	+	19	11425	c.11408C>T	c.(11407-11409)cCg>cTg	p.P3803L	FAT3_ENST00000525166.1_Missense_Mutation_p.P3653L|FAT3_ENST00000533797.1_Missense_Mutation_p.P138L|FAT3_ENST00000409404.2_Missense_Mutation_p.P3803L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3803	EGF-like 1.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGAGAAGCCGTGTCCAGGG	0.557000										TCGA Ovarian(4;0.039)			19	81					0	0	1	0	0
LOC400794	400794	broad.mit.edu	37	1	165551093	165551093	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165551093C>T	ENST00000438275.1	-	0	272				RP11-280O1.2_ENST00000421273.1_RNA|RP11-280O1.2_ENST00000416424.1_RNA																							TCTCCCTGCCCATCACGGAAT	0.557000													3	5					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367193	107367193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107367193G>A	ENST00000542196.1	-	1	758	c.716C>T	c.(715-717)tCt>tTt	p.S239F		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						TGAACAGGTAGAGGAAGCTTT	0.403000													29	64					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73617662	73617662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73617662C>T	ENST00000261917.3	-	5	2707	c.1714G>A	c.(1714-1716)Gag>Aag	p.E572K		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	572					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		TCGCTTAGCTCGCCCAGGATG	0.677000													22	79					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205132913	205132913	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205132913G>A	ENST00000367162.3	-	4	1525	c.1495C>T	c.(1495-1497)Ctg>Ttg	p.L499L	DSTYK_ENST00000367161.3_Silent_p.L499L|DSTYK_ENST00000367160.4_Intron	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	499						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						AGGCTCTGCAGACATCGTTCC	0.453000													10	42					0	0	1	0	0
ASUN	55726	broad.mit.edu	37	12	27081176	27081176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:27081176C>T	ENST00000261191.7	-	5	1082	c.546G>A	c.(544-546)acG>acA	p.T182T	ASUN_ENST00000539625.1_Silent_p.T81T	NM_018164.2	NP_060634.2	Q9NVM9	M89BB_HUMAN	asunder spermatogenesis regulator	182					cell division|mitosis|regulation of mitotic cell cycle		protein binding										GTTCATGAATCGTTTCCTGGA	0.294000													11	84					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569726	241569726	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241569726G>A	ENST00000319838.5	+	6	1299	c.357G>A	c.(355-357)cgG>cgA	p.R119R	GPR35_ENST00000430267.1_Silent_p.R119R|GPR35_ENST00000407714.1_Silent_p.R119R|GPR35_ENST00000403859.1_Silent_p.R119R|GPR35_ENST00000438013.2_Silent_p.R150R	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	119						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		TGGCCGTGCGGCACCCGCTGC	0.711000													9	24					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140416159	140416159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140416159C>T	ENST00000406427.1	-	10	1222	c.886G>A	c.(886-888)Gtg>Atg	p.V296M	PNPLA7_ENST00000277531.4_Missense_Mutation_p.V271M	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	271					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TGCAGCCGCACCATGATGATC	0.617000													14	45					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10769819	10769819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10769819C>T	ENST00000283025.2	-	5	1154	c.1083G>A	c.(1081-1083)gcG>gcA	p.A361A		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	361					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						TGCTCACCTTCGCCAGCTGCG	0.592000													9	81					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10089637	10089637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10089637C>T	ENST00000264828.3	-	40	2979	c.2894G>A	c.(2893-2895)gGa>gAa	p.G965E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	965	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CCCAAGGGGTCCTGGTGGTCC	0.637000													5	15					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33015577	33015577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:33015577C>T	ENST00000280979.4	+	4	1888	c.1718C>T	c.(1717-1719)tCc>tTc	p.S573F	AKAP6_ENST00000557272.1_Missense_Mutation_p.S573F|AKAP6_ENST00000557354.1_Missense_Mutation_p.S573F	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	573					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCAGAAACATCCAGTTCACCA	0.443000													37	93					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100680532	100680532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100680532C>T	ENST00000306151.4	+	3	5899	c.5835C>T	c.(5833-5835)acC>acT	p.T1945T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1945	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AAATCAACACCCTTTCAACAA	0.502000													146	375					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291974	33291974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:33291974G>A	ENST00000280979.4	+	13	5125	c.4955G>A	c.(4954-4956)cGa>cAa	p.R1652Q	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1652	Ser-rich.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAGATAAAACGAAGTGTTTCT	0.423000													20	60					0	0	1	0	0
C4orf50	389197	broad.mit.edu	37	4	5961342	5961342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:5961342G>A	ENST00000531445.1	-	7	2059	c.2013C>T	c.(2011-2013)tcC>tcT	p.S671S	C4orf50_ENST00000324058.5_Silent_p.S197S			Q6ZRC1	CD050_HUMAN	chromosome 4 open reading frame 50	197										breast(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(2)|skin(3)|urinary_tract(1)	15						TGGACACCAAGGACAGAGGGA	0.527000													8	33					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835344	38835344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38835344G>A	ENST00000449082.2	-	1	157	c.158C>T	c.(157-159)cCc>cTc	p.P53L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	53					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTCCAGCTGGGGCCGAGGCTT	0.542000													61	119					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2436207	2436207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2436207G>A	ENST00000452833.1	-	10	1564	c.1556C>T	c.(1555-1557)cCc>cTc	p.P519L	TRPM5_ENST00000155858.6_Missense_Mutation_p.P517L|TRPM5_ENST00000533060.1_Missense_Mutation_p.P517L|TRPM5_ENST00000528453.1_Missense_Mutation_p.P517L			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	517						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTCCCGCCAGGGGTTCTCGCT	0.706000													7	21					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53062516	53062516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:53062516C>T	ENST00000276480.7	-	16	2511	c.1828G>A	c.(1828-1830)Gaa>Aaa	p.E610K		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	610						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GTGCCATTTTCATCCACTTCT	0.418000													36	86					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028546	37028546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37028546C>T	ENST00000358047.3	+	1	2115	c.2063C>T	c.(2062-2064)tCt>tTt	p.S688F		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	688										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						ACTCGCGTATCTCATCTCCGC	0.657000													30	28					0	0	1	0	0
TPM1	7168	broad.mit.edu	37	15	63354877	63354877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:63354877C>T	ENST00000560959.1	+	7	711	c.697C>T	c.(697-699)Ctt>Ttt	p.L233F	TPM1_ENST00000288398.6_Intron|TPM1_ENST00000403994.3_Intron|TPM1_ENST00000559397.1_Intron|TPM1_ENST00000559281.1_Intron|TPM1_ENST00000559556.1_Intron|TPM1_ENST00000334895.5_Intron|TPM1_ENST00000404484.4_Intron|TPM1_ENST00000560445.1_Intron|TPM1_ENST00000358278.3_Intron|TPM1_ENST00000317516.7_Intron|TPM1_ENST00000357980.4_Intron|TPM1_ENST00000267996.7_Intron			P09493	TPM1_HUMAN	tropomyosin 1 (alpha)	0					cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle			endometrium(1)|large_intestine(1)|lung(2)	4						TAGTTTAATCCTTATGGTTGA	0.408000													10	63					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520541	33520541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33520541G>A	ENST00000297307.5	-	1	871	c.786C>T	c.(784-786)ctC>ctT	p.L262L		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	262						integral to membrane											AGACCAAGGCGAGGATCCCCA	0.627000													29	70					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67703945	67703945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:67703945C>T	ENST00000545606.1	+	13	3646	c.3209C>T	c.(3208-3210)cCa>cTa	p.P1070L		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	1070					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GAAATGGGTCCATTTAAACAT	0.353000													21	152					0	0	1	0	0
FUT5	2527	broad.mit.edu	37	19	5867474	5867474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5867474G>A	ENST00000252675.5	-	5	825	c.263C>T	c.(262-264)cCc>cTc	p.P88L	FUT5_ENST00000588525.1_Missense_Mutation_p.P88L			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	88					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						CAGAGCCACGGGTGTGTTAAA	0.662000													9	74					0	0	1	0	0
KIAA1045	23349	broad.mit.edu	37	9	34976624	34976624	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34976624G>A	ENST00000242315.3	+	5	818	c.736G>A	c.(736-738)Gag>Aag	p.E246K	KIAA1045_ENST00000476115.2_3'UTR|KIAA1045_ENST00000544237.1_Missense_Mutation_p.E246K	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	246							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			GGAGCAAGAAGAGCAGGCGGC	0.612000													18	65					0	0	1	0	0
UBE3A	7337	broad.mit.edu	37	15	25585324	25585324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25585324G>A	ENST00000232165.3	-	12	3062	c.2406C>T	c.(2404-2406)ttC>ttT	p.F802F	UBE3A_ENST00000397954.2_Silent_p.F805F|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000566215.1_Silent_p.F782F|UBE3A_ENST00000438097.1_Silent_p.F782F|UBE3A_ENST00000428984.2_Silent_p.F782F	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	805	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TAAACTGCAAGAAGAGTCTTT	0.393000													24	98					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21750215	21750215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21750215G>A	ENST00000328843.6	+	42	6780	c.6749G>A	c.(6748-6750)cGa>cAa	p.R2250Q	DNAH11_ENST00000409508.3_Missense_Mutation_p.R2243Q			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2250	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TCCATTCTACGAGAACAAGCA	0.343000									Kartagener syndrome				9	37					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1050936	1050936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1050936C>T	ENST00000263094.6	+	19	2800	c.2569C>T	c.(2569-2571)Ctc>Ttc	p.L857F	ABCA7_ENST00000435683.2_Missense_Mutation_p.L719F|ABCA7_ENST00000433129.1_Missense_Mutation_p.L857F	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	857	ABC transporter 1.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTGAGTGGCCTCTTCCCACC	0.562000													34	69					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23855800	23855800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23855800G>A	ENST00000405093.3	-	33	4753	c.4683C>T	c.(4681-4683)ctC>ctT	p.L1561L	MYH6_ENST00000356287.3_Silent_p.L1561L	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1561					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCTGGGCCCGGAGGATCTTGC	0.642000													77	183					0	0	1	0	0
CHRM5	1133	broad.mit.edu	37	15	34356343	34356343	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34356343C>T	ENST00000383263.5	+	3	2095	c.1425C>T	c.(1423-1425)acC>acT	p.T475T	CHRM5_ENST00000557872.1_Silent_p.T475T	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	475					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	TCCCAGTCACCCTGTGGCACT	0.498000													30	72					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50759407	50759407	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50759407G>A	ENST00000300589.2	+	10	2995	c.2890G>A	c.(2890-2892)Gag>Aag	p.E964K		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	964					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				CAGCCTGGAGGAGAACCATCT	0.418000													15	52					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068442	5068442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5068442C>T	ENST00000380370.1	+	1	687	c.687C>T	c.(685-687)ctC>ctT	p.L229L		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTTCCGCCTCCCATCACATG	0.448000													72	143					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101587521	101587521	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101587521G>A	ENST00000536262.2	-	5	1132	c.574C>T	c.(574-576)Caa>Taa	p.Q192*		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	192					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ATCCCAACTTGAAAAACATCT	0.398000													26	162					0	0	1	0	0
C15orf32	145858	broad.mit.edu	37	15	93015449	93015449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93015449G>A	ENST00000333334.2	+	1	566	c.71G>A	c.(70-72)gGg>gAg	p.G24E	C15orf32_ENST00000556865.1_Missense_Mutation_p.G24E	NM_153040.2	NP_694585.1	Q32M92	CO032_HUMAN	chromosome 15 open reading frame 32	24										endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	12	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			AGTGGGGAAGGGGTCCCACCT	0.537000													20	97					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75108735	75108735	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75108735C>T	ENST00000326665.5	-	4	509	c.291G>A	c.(289-291)agG>agA	p.R97R		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	97										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTCGCTCCTTCCTAGCTAAGG	0.318000													27	77					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836667	142836667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142836667G>A	ENST00000291009.3	+	4	413	c.373G>A	c.(373-375)Gat>Aat	p.D125N		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	125						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		CATCTGCCCTGATGATGCTGC	0.473000													59	164					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220466102	220466102	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220466102C>T	ENST00000456909.1	+	3	297	c.207C>T	c.(205-207)tcC>tcT	p.S69S	STK11IP_ENST00000295641.10_Silent_p.S80S|STK11IP_ENST00000459692.1_3'UTR			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	80					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGCCGACTCCCCTGTTATTC	0.567000													16	50					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16532066	16532066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16532066G>A	ENST00000270747.3	-	9	1684	c.1548C>T	c.(1546-1548)ttC>ttT	p.F516F	ARHGEF19_ENST00000421561.1_Intron|ARHGEF19_ENST00000478117.1_5'UTR	NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	516	DH.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		TGATCCTCTGGAAGGGCAGGA	0.647000													13	28					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581366	140581366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140581366C>T	ENST00000354757.3	+	1	2019	c.2019C>T	c.(2017-2019)ctC>ctT	p.L673L	PCDHB11_ENST00000536699.1_Silent_p.L308L	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		673					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTGCCGCTCCCTGAGGCGG	0.682000													41	144					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711257	155711257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:155711257G>A	ENST00000295101.2	+	3	1415	c.938G>A	c.(937-939)cGa>cAa	p.R313Q	KCNJ3_ENST00000493505.1_3'UTR|KCNJ3_ENST00000544049.1_3'UTR	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	313					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	TGTCAAGCTCGAACATCATAT	0.358000													30	80					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	53017610	53017610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:53017610G>A	ENST00000354452.3	-	8	1140	c.529C>T	c.(529-531)Cct>Tct	p.P177S	TCF4_ENST00000566279.1_Intron|TCF4_ENST00000543082.1_Missense_Mutation_p.P135S|TCF4_ENST00000540999.1_Missense_Mutation_p.P153S|TCF4_ENST00000537856.3_Missense_Mutation_p.P47S|TCF4_ENST00000544241.2_Missense_Mutation_p.P106S|TCF4_ENST00000564403.2_Missense_Mutation_p.P177S|TCF4_ENST00000570177.2_Missense_Mutation_p.P47S|TCF4_ENST00000568740.1_Missense_Mutation_p.P152S|TCF4_ENST00000564228.1_Missense_Mutation_p.P106S|TCF4_ENST00000537578.1_Missense_Mutation_p.P153S|TCF4_ENST00000565018.2_Missense_Mutation_p.P177S|TCF4_ENST00000356073.4_Missense_Mutation_p.P177S|TCF4_ENST00000564999.1_Missense_Mutation_p.P177S|TCF4_ENST00000561992.1_Missense_Mutation_p.P47S|TCF4_ENST00000398339.1_Missense_Mutation_p.P279S|TCF4_ENST00000568673.1_Missense_Mutation_p.P153S|TCF4_ENST00000566286.1_Missense_Mutation_p.P175S|TCF4_ENST00000567880.1_Intron	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	177					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		AAACCTGGAGGAACTTTTCGA	0.363000													23	69					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103294550	103294550	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103294550G>A	ENST00000424685.2	-	13	1703	c.1544C>T	c.(1543-1545)tCc>tTc	p.S515F	RELN_ENST00000343529.5_Missense_Mutation_p.S515F|RELN_ENST00000428762.1_Missense_Mutation_p.S515F			P78509	RELN_HUMAN	reelin	515					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTTATATGAGGAATAGGAAAG	0.428000													23	64					0	0	1	0	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89916702	89916702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:89916702G>A	ENST00000548729.1	-	3	1918	c.1616C>T	c.(1615-1617)cCa>cTa	p.P539L	POC1B_ENST00000549035.1_Intron|GALNT4_ENST00000529983.2_Missense_Mutation_p.P542L|POC1B_ENST00000313546.3_Intron|POC1B_ENST00000541909.1_Intron|POC1B-GALNT4_ENST00000413530.1_Missense_Mutation_p.P370L|POC1B-GALNT4_ENST00000547474.1_3'UTR|POC1B_ENST00000549504.1_Intron|POC1B_ENST00000393179.4_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					TCCTGAGTGTGGGTGAAAAAT	0.398000													8	78					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703507	55703507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55703507G>A	ENST00000301532.3	-	1	369	c.370C>T	c.(370-372)Cgc>Tgc	p.R124C		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GCGACATAGCGATCATAGGCC	0.438000													20	69					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85997276	85997276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85997276C>T	ENST00000372105.3	-	2	310	c.289G>A	c.(289-291)Gag>Aag	p.E97K		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	97						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GCGTTGAGCTCGCTGAGGGCG	0.736000													9	14					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378801	114378801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:114378801C>T	ENST00000312719.5	-	5	1849	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K	HS3ST5_ENST00000411826.1_Missense_Mutation_p.E221K|RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000523087.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	221					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GTGTTCACTTCGCATGTATTA	0.398000													87	143					0	0	1	0	0
FAM21EP	100421577	broad.mit.edu	37	10	51818892	51818892	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:51818892G>A	ENST00000456967.1	-	0	1538					NR_038275.1																						GGGGTGTCGAGAAAAAGtcgt	0.502000													11	21					0	0	1	0	0
C11orf71	54494	broad.mit.edu	37	11	114270917	114270917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:114270917G>A	ENST00000325636.4	-	1	222	c.137C>T	c.(136-138)cCt>cTt	p.P46L	RBM7_ENST00000540163.1_5'UTR	NM_019021.2	NP_061894.2	Q6IPW1	CK071_HUMAN	chromosome 11 open reading frame 71	46										large_intestine(3)|lung(1)	4		all_cancers(61;1.15e-11)|all_epithelial(67;5.3e-06)|all_hematologic(158;0.000303)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.6e-06)|Epithelial(105;4.31e-05)|all cancers(92;0.00036)		AATCGCTTCAGGCCTGGAAAC	0.662000													8	24					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86010787	86010787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:86010787C>T	ENST00000383699.3	+	8	1587	c.960C>T	c.(958-960)ctC>ctT	p.L320L	CADM2_ENST00000407528.2_Silent_p.L311L|CADM2_ENST00000405615.2_Silent_p.L313L	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	311	Thr-rich.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AATATGTTCTCATTGTGCATG	0.348000													21	82					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77290750	77290750	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77290750C>T	ENST00000388914.3	-	10	1328	c.1176G>A	c.(1174-1176)gaG>gaA	p.E392E		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	392										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CCAGACTCAGCTCCTTCTCCC	0.443000													15	69					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345226	33345226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33345226G>A	ENST00000374796.2	-	8	3895	c.1325C>T	c.(1324-1326)tCc>tTc	p.S442F	NCOA6_ENST00000359003.2_Missense_Mutation_p.S442F			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	442	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CGTTGGGGAGGATGCAGGGGA	0.602000													31	79					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128595285	128595285	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:128595285C>T	ENST00000335251.5	+	6	1201	c.1098C>T	c.(1096-1098)tcC>tcT	p.S366S	INTU_ENST00000296461.5_Silent_p.S366S	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	366										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						TTAGTTCATCCCTCCTTTTAA	0.303000													11	46					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57714214	57714214	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57714214G>A	ENST00000333493.4	+	7	866	c.705G>A	c.(703-705)acG>acA	p.T235T	GPR97_ENST00000327655.6_Silent_p.T25T|GPR97_ENST00000450388.3_Silent_p.T115T	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	235	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GCTGCTCCACGGAGGTCAGAC	0.627000													11	51					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916456	42916456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42916456C>T	ENST00000316161.4	-	1	1177	c.853G>A	c.(853-855)Ggg>Agg	p.G285R	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Missense_Mutation_p.G285R|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	285					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCCGTGTTCCCCTGGGAGGCC	0.582000													8	17					0	0	1	0	0
SRRM1	10250	broad.mit.edu	37	1	24989170	24989170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24989170C>T	ENST00000323848.9	+	12	1818	c.1503C>T	c.(1501-1503)tcC>tcT	p.S501S	SRRM1_ENST00000537199.1_3'UTR|SRRM1_ENST00000374389.4_Silent_p.S496S|SRRM1_ENST00000479034.1_3'UTR|SRRM1_ENST00000447431.2_Silent_p.S499S	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	501	Arg-rich.|Necessary for speckles and matrix localization.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CCTCCTCCTCCTCAGAAGATG	0.453000													14	104					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100502	93100502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:93100502G>A	ENST00000544406.2	+	2	361	c.95G>A	c.(94-96)gGg>gAg	p.G32E	C12orf74_ENST00000397833.3_Missense_Mutation_p.G32E			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	32										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						AAGAACCAGGGGAGTCTCCTC	0.597000													17	41					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84256408	84256408	+	Silent	SNP	C	C	T	rs113623603		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84256408C>T	ENST00000308251.4	-	3	1043	c.975G>A	c.(973-975)ggG>ggA	p.G325G		NM_172347.2	NP_758857.1	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	325			G -> R (in dbSNP:rs7196482).			voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GGTAGGAGCTCCCGCTCGGCC	0.672000													4	16					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565267	58565267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58565267G>A	ENST00000282326.1	+	6	1322	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	359					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGGCCCCCGGGAGTCCGTCCC	0.657000													17	33					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53814059	53814059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53814059G>A	ENST00000288139.3	+	39	4772	c.4654G>A	c.(4654-4656)Gtt>Att	p.V1552I	CACNA1D_ENST00000422281.2_Missense_Mutation_p.V1517I|CACNA1D_ENST00000350061.5_Missense_Mutation_p.V1532I|CACNA1D_ENST00000540742.1_Missense_Mutation_p.V424I	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1532					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACAGAGATTAGTTGCCATGAA	0.418000													20	93					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801106	185801106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185801106C>T	ENST00000302277.6	+	4	1577	c.983C>T	c.(982-984)tCa>tTa	p.S328L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	328						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGTCAAAATTCAGTCCCATTA	0.323000													17	45					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1437219	1437219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1437219G>A	ENST00000345913.4	+	4	280	c.189G>A	c.(187-189)aaG>aaA	p.K63K	TPO_ENST00000337415.3_Silent_p.K63K|TPO_ENST00000382269.3_Silent_p.K63K|TPO_ENST00000497517.2_Intron|TPO_ENST00000346956.3_Silent_p.K63K|TPO_ENST00000349624.3_Silent_p.K63K|TPO_ENST00000382201.3_Silent_p.K63K|TPO_ENST00000329066.4_Silent_p.K63K|TPO_ENST00000382198.1_Silent_p.K63K|TPO_ENST00000539820.1_Silent_p.K63K	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	63					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GAAACCTCAAGAAAAGAGGAA	0.363000													32	65					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373732	86373732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:86373732C>T	ENST00000604798.1	-	8	1976	c.772G>A	c.(772-774)Ggc>Agc	p.G258S	MGAT4C_ENST00000552808.2_Missense_Mutation_p.G258S|MGAT4C_ENST00000552435.2_Intron|MGAT4C_ENST00000393205.2_Missense_Mutation_p.G287S|MGAT4C_ENST00000549405.2_Missense_Mutation_p.G258S|MGAT4C_ENST00000332156.1_Missense_Mutation_p.G258S|MGAT4C_ENST00000548651.1_Missense_Mutation_p.G258S			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	258					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CCAATGTAGCCAAGCTTAGAG	0.363000													17	79					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1077677	1077677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1077677C>T	ENST00000441003.2	+	3	454	c.427C>T	c.(427-429)Ctc>Ttc	p.L143F	MUC2_ENST00000359061.5_Missense_Mutation_p.L143F	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	143	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCGCGCCGGCCTCACCCTCAT	0.672000													8	18					0	0	1	0	0
ZC4H2	55906	broad.mit.edu	37	X	64141826	64141826	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:64141826C>T	ENST00000545618.1	-	3	644	c.81G>A	c.(79-81)aaG>aaA	p.K27K	ZC4H2_ENST00000374839.3_Silent_p.K32K|ZC4H2_ENST00000447788.2_Silent_p.K32K|ZC4H2_ENST00000337990.2_Silent_p.K9K|ZC4H2_ENST00000488608.1_5'UTR			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	32							metal ion binding|protein binding	p.K32N(2)		endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CAAACTCAGCCTTCAAACGAG	0.483000													21	10					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	431895	431895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:431895C>T	ENST00000332826.6	-	6	502	c.418G>A	c.(418-420)Gat>Aat	p.D140N		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	140						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						TTCATCAGATCCTCGAAGGTC	0.677000													6	40					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65621418	65621418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65621418G>A	ENST00000327987.4	-	14	2525	c.2274C>T	c.(2272-2274)ggC>ggT	p.G758G		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	758										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCTCCATCAGGCCGCACCCCT	0.706000													11	3					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10916768	10916768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10916768C>T	ENST00000254488.2	+	6	945	c.879C>T	c.(877-879)ctC>ctT	p.L293L		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	293					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCTCCCGGCTCTCCGACCCCC	0.592000													36	60					0	0	1	0	0
RPP14	11102	broad.mit.edu	37	3	58296101	58296101	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58296101C>T	ENST00000445193.2	+	2	456	c.45C>T	c.(43-45)aaC>aaT	p.N15N	RPP14_ENST00000544156.1_5'UTR|RPP14_ENST00000477305.1_Intron|RPP14_ENST00000466547.1_Silent_p.N15N|RPP14_ENST00000295959.5_Silent_p.N15N	NM_001098783.2	NP_001092253.1	O95059	RPP14_HUMAN	ribonuclease P/MRP 14kDa subunit	15					tRNA processing	nucleus	identical protein binding|ribonuclease P activity|RNA binding			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.000187)|KIRC - Kidney renal clear cell carcinoma(10;0.0102)|Kidney(10;0.0118)|OV - Ovarian serous cystadenocarcinoma(275;0.191)		TTTACAAAAACCCTTCCGAGT	0.383000													27	76					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3673354	3673354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3673354G>A	ENST00000294600.2	+	4	695	c.611G>A	c.(610-612)aGa>aAa	p.R204K		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	204								p.R204I(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CGGAAGAGGAGAAAATCCCAG	0.547000													21	73					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113235516	113235516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113235516C>T	ENST00000369644.1	+	8	1966	c.937C>T	c.(937-939)Cct>Tct	p.P313S	MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000413052.2_Missense_Mutation_p.P369S|MOV10_ENST00000369645.1_Missense_Mutation_p.P369S|MOV10_ENST00000357443.2_Missense_Mutation_p.P369S			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	369					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GACCTGGGACCCTGTGGACCA	0.612000													7	21					0	0	1	0	0
SLC7A4	6545	broad.mit.edu	37	22	21385560	21385560	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21385560G>A	ENST00000382932.2	-	2	609	c.542C>T	c.(541-543)tCt>tTt	p.S181F	SLC7A4_ENST00000403586.1_Missense_Mutation_p.S181F	NM_004173.2	NP_004164.2	O43246	CTR4_HUMAN	solute carrier family 7, member 4	181				THVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSS -> DPRGFLAGAPPGPLPGLPGCWHHPPWPLPLSPVEPACPP (in Ref. 1; CAA04263).	cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(2)	18	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GACAAAGGCAGAGGCCAGGAG	0.597000													18	28					0	0	1	0	0
MXRA8	54587	broad.mit.edu	37	1	1290116	1290116	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1290116G>C	ENST00000309212.6	-	5	925	c.895C>G	c.(895-897)Ccc>Gcc	p.P299A	MXRA8_ENST00000342753.4_Missense_Mutation_p.P198A|MXRA8_ENST00000445648.2_Missense_Mutation_p.P299A	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	299						integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCCCGGGGGGGCGGCTCCGCG	0.731000													7	20					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122757604	122757604	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122757604G>A	ENST00000194130.2	-	14	1610	c.1571C>T	c.(1570-1572)tCa>tTa	p.S524L	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	524						integral to membrane|plasma membrane	sodium:sulfate symporter activity	p.S524L(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	GAATGCAAATGAAGTACACAG	0.368000													30	67					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714929	92714929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92714929C>T	ENST00000257068.2	+	2	546	c.540C>T	c.(538-540)tcC>tcT	p.S180S		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	180					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	TTGTGGGGTCCCTGGAGTACG	0.612000													9	62					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47401236	47401236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47401236C>T	ENST00000310638.4	-	5	625	c.594G>A	c.(592-594)atG>atA	p.M198I	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Missense_Mutation_p.M198I|CYP4A11_ENST00000371905.1_Missense_Mutation_p.M198I|CYP4A11_ENST00000457840.2_Missense_Mutation_p.M94I	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	198					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	AGGCACACTTCATGATGGTGT	0.572000													28	89					0	0	1	0	0
WBP1L	54838	broad.mit.edu	37	10	104572539	104572539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104572539C>T	ENST00000369889.4	+	4	622	c.480C>T	c.(478-480)ccC>ccT	p.P160P	WBP1L_ENST00000448841.1_Silent_p.P181P	NM_017787.4	NP_060257.4	Q9NX94	OPA1L_HUMAN	WW domain binding protein 1-like	160	Pro-rich.					integral to membrane											AGAGCAGCCCCTTGTCTGAGC	0.647000													25	32					0	0	1	0	0
IGLV11-55	28770	broad.mit.edu	37	22	22556304	22556304	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22556304C>T	ENST00000390286.2	+	0	130																											AGCCAGACTCCCCTGCACCCT	0.582000											OREG0026354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	55					0	0	1	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239242627	239242627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239242627G>A	ENST00000373327.4	+	7	1236	c.1014G>A	c.(1012-1014)aaG>aaA	p.K338K	TRAF3IP1_ENST00000391994.2_Silent_p.K338K|TRAF3IP1_ENST00000391993.3_Silent_p.K338K	NM_015650.3	NP_056465.2	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting protein 1	338	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(2)	23		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		GAGCTTCCAAGTCATTGACAA	0.299000													6	29					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587557	55587557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55587557C>T	ENST00000333976.4	+	1	472	c.452C>T	c.(451-453)gCc>gTc	p.A151V		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				GGATCCTATGCCTGGGGAGTC	0.478000													23	167					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102490132	102490132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102490132C>T	ENST00000413150.2	+	21	2341	c.2286C>T	c.(2284-2286)ctC>ctT	p.L762L	MAP4K4_ENST00000302217.5_Silent_p.L650L|MAP4K4_ENST00000347699.4_Silent_p.L847L|MAP4K4_ENST00000425019.1_Silent_p.L880L|MAP4K4_ENST00000350878.4_Silent_p.L887L|MAP4K4_ENST00000456652.1_Silent_p.L646L|MAP4K4_ENST00000350198.4_Silent_p.L766L|MAP4K4_ENST00000324219.4_Silent_p.L928L	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	847					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GTAGCACACTCCAGAAACACA	0.363000													6	24					0	0	1	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81443974	81443974	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81443974G>A	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							CTACGGGGACGGCGGCAAGCA	0.632000													4	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179633472	179633472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179633472G>A	ENST00000589042.1	-	38	9315	c.9091C>T	c.(9091-9093)Cac>Tac	p.H3031Y	TTN_ENST00000342992.6_Missense_Mutation_p.H3031Y|TTN_ENST00000360870.5_Missense_Mutation_p.H3031Y|TTN_ENST00000591111.1_Missense_Mutation_p.H3031Y|TTN_ENST00000342175.6_Missense_Mutation_p.H2985Y|TTN_ENST00000359218.5_Missense_Mutation_p.H2985Y|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.H2985Y	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2770	Ig-like 17.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCCAAAGTGAACATTCCTG	0.408000													17	62					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170819401	170819401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170819401C>T	ENST00000436636.2	-	22	2772	c.2428G>A	c.(2428-2430)Gaa>Aaa	p.E810K	TNIK_ENST00000470834.1_Missense_Mutation_p.E773K|TNIK_ENST00000369326.5_Missense_Mutation_p.E788K|TNIK_ENST00000475336.1_Missense_Mutation_p.E718K|TNIK_ENST00000538048.1_Missense_Mutation_p.E762K|TNIK_ENST00000357327.5_Missense_Mutation_p.E781K|TNIK_ENST00000488470.1_Missense_Mutation_p.E755K|TNIK_ENST00000284483.8_Missense_Mutation_p.E802K|TNIK_ENST00000460047.1_Missense_Mutation_p.E747K|TNIK_ENST00000341852.6_Missense_Mutation_p.E726K	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	810	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCTCTTAGTTCTTTGGCTAAT	0.453000													25	66					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82764008	82764008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82764008C>T	ENST00000423517.2	-	3	3195	c.2858G>A	c.(2857-2859)gGa>gAa	p.G953E	PCLO_ENST00000333891.8_Missense_Mutation_p.G953E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	899	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGAATGAGGTCCAGGTTGGCC	0.522000													11	26					0	0	1	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94335415	94335415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94335415G>A	ENST00000436063.2	-	7	2320	c.2263C>T	c.(2263-2265)Cgc>Tgc	p.R755C		NM_014597.4	NP_055412.2	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 2	755					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	38		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TCTTAATTGCGAAATTTCTTC	0.323000													14	34					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56388020	56388020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56388020G>A	ENST00000355701.3	-	20	4422	c.3552C>T	c.(3550-3552)ccC>ccT	p.P1184P	BZRAP1_ENST00000268893.6_Silent_p.P1124P|BZRAP1_ENST00000343736.4_Silent_p.P1184P	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1184						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGGCCAGTGAGGGAGCTGCGG	0.672000													8	24					0	0	1	0	0
ADAMTSL5	339366	broad.mit.edu	37	19	1506656	1506656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1506656G>A	ENST00000330475.4	-	11	1490	c.1047C>T	c.(1045-1047)ccC>ccT	p.P349P	ADAMTSL5_ENST00000413997.2_Silent_p.P359P|ADAMTSL5_ENST00000395467.2_Intron|ADAMTSL5_ENST00000590562.1_5'UTR	NM_213604.2	NP_998769.2	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5	349						proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGTGGGCAGGGGTCTGTGG	0.682000													5	5					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169842719	169842719	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169842719G>A	ENST00000263817.6	-	10	1108	c.984C>T	c.(982-984)ttC>ttT	p.F328F		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	328	ABC transmembrane type-1 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GACACCACACGAATCCAGTAA	0.453000													34	76					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59112786	59112786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:59112786C>T	ENST00000395153.3	+	4	1481	c.1334C>T	c.(1333-1335)tCa>tTa	p.S445L	DACT1_ENST00000541264.2_Missense_Mutation_p.S201L|DACT1_ENST00000395151.3_Missense_Mutation_p.S201L|DACT1_ENST00000335867.4_Missense_Mutation_p.S482L|DACT1_ENST00000556859.1_Missense_Mutation_p.S201L	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	482					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						GCTCAGCTCTCAGGGGCCTCT	0.567000													42	106					0	0	1	0	0
IGLV1-44	28823	broad.mit.edu	37	22	22735275	22735275	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22735275C>T	ENST00000390297.2	+	0	141																											TCCTCCTCACCCTCCTCACTC	0.577000													5	11					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115806300	115806300	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:115806300T>C	ENST00000374227.3	-	4	625	c.598A>G	c.(598-600)Agg>Ggg	p.R200G	ZFP37_ENST00000553380.1_Missense_Mutation_p.R215G|ZFP37_ENST00000555206.1_Missense_Mutation_p.R201G			Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	200						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						TCAGATTTCCTTTTTACACAG	0.328000													51	96					0	0	1	0	0
IQSEC1	9922	broad.mit.edu	37	3	12983267	12983267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12983267G>A	ENST00000273221.4	-	2	380	c.164C>T	c.(163-165)cCg>cTg	p.P55L	IQSEC1_ENST00000473088.1_5'UTR	NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	55					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GTAGTGATCCGGGCTCAGGCT	0.697000													9	24					0	0	1	0	0
HAUS1	115106	broad.mit.edu	37	18	43698189	43698189	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43698189C>T	ENST00000282058.6	+	3	328	c.248C>T	c.(247-249)tCc>tTc	p.S83F	HAUS1_ENST00000588704.1_3'UTR|HAUS1_ENST00000585518.1_Intron	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	83					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						GTGAATTTTTCCCCCGCCAAT	0.418000													35	107					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578782	9578782	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9578782G>A	ENST00000301480.4	-	10	1054	c.841C>T	c.(841-843)Cag>Tag	p.Q281*		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						CTCTGGACCTGAACATTTAAA	0.383000													40	98					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33521168	33521168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33521168G>A	ENST00000297307.5	-	1	244	c.159C>T	c.(157-159)ttC>ttT	p.F53F		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	53	DUF6 1.					integral to membrane		p.F53F(1)									GGGGGCCCACGAAGCCAGCAG	0.667000													30	38					0	0	1	0	0
MOS	4342	broad.mit.edu	37	8	57026495	57026495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57026495G>A	ENST00000311923.1	-	1	46	c.47C>T	c.(46-48)tCc>tTc	p.S16F		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog	16							ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			CACCGATGGGGAAAACTCGCT	0.692000													11	31					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62740234	62740234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62740234C>T	ENST00000371153.4	-	3	920	c.542G>A	c.(541-543)aGc>aAc	p.S181N	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	181										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GGGCCCCAGGCTCAGGCCTGG	0.637000													4	33					0	0	1	0	0
CYP4V2	285440	broad.mit.edu	37	4	187118158	187118158	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187118158G>A	ENST00000378802.4	+	4	782	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K		NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	160					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		TACCATTCTGGAAGATTTCTT	0.308000													27	71					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332734	22332734	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22332734G>A	ENST00000558896.1	+	0	541																											CACTTTCTAGGAGCCAGTGAG	0.473000													9	39					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166229797	166229797	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166229797C>T	ENST00000357398.3	+	21	4202	c.3912C>T	c.(3910-3912)tcC>tcT	p.S1304S	SCN2A_ENST00000375437.2_Silent_p.S1304S|SCN2A_ENST00000375427.2_Silent_p.S1304S|SCN2A_ENST00000283256.6_Silent_p.S1304S			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1304					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.S1304S(2)		NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CCATCAAATCCCTCAGAACAC	0.408000													29	125					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6833919	6833919	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6833919G>A	ENST00000304076.2	+	19	1826	c.1731_splice	c.e19-1	p.D578_splice	VAV1_ENST00000596764.1_Splice_Site_p.D546_splice|VAV1_ENST00000539284.1_Splice_Site_p.D481_splice|VAV1_ENST00000599806.1_Splice_Site_p.D523_splice|VAV1_ENST00000602142.1_Splice_Site_p.D578_splice	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	578					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CTCCTTCCAGGACAAACTACA	0.537000													31	79					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169201675	169201675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169201675C>T	ENST00000393743.3	-	14	2080	c.1789G>A	c.(1789-1791)Gaa>Aaa	p.E597K		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	597							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TTTTGCTCTTCCTTTTGTTCT	0.363000													16	51					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59210841	59210841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59210841G>A	ENST00000302030.2	+	1	225	c.200G>A	c.(199-201)aGc>aAc	p.S67N		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S67I(1)		central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						TTCTTCCTAAGCAACTTATCT	0.483000													56	150					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28127349	28127349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28127349G>A	ENST00000316334.3	-	8	1903	c.1774C>T	c.(1774-1776)Ccc>Tcc	p.P592S		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	592							zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CAGTACCTGGGAAGCCCAAGC	0.473000													9	86					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1047173	1047173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1047173C>T	ENST00000263094.6	+	15	2094	c.1863C>T	c.(1861-1863)ccC>ccT	p.P621P	ABCA7_ENST00000435683.2_Silent_p.P483P|ABCA7_ENST00000433129.1_Silent_p.P621P|ABCA7_ENST00000533574.1_3'UTR	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	621					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACATCCTCCCCTACAGCCACC	0.677000													5	14					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39879646	39879646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39879646G>A	ENST00000260356.5	+	8	1384	c.1219G>A	c.(1219-1221)Gat>Aat	p.D407N		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	407	TSP type-1 1.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CCGCTCCTGCGATAGCCTCAA	0.587000													13	30					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2546846	2546846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2546846C>T	ENST00000567020.1	+	2	837	c.697C>T	c.(697-699)Ctg>Ttg	p.L233L	TBC1D24_ENST00000293970.5_Silent_p.L233L|RP11-20I23.1_ENST00000564543.1_Silent_p.L233L|TBC1D24_ENST00000434757.2_Silent_p.L233L	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	233	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						TGACGTCTTCCTGGTGGAGGG	0.642000													12	51					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299274	58299274	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58299274G>T	ENST00000377918.3	+	4	3352	c.3326G>T	c.(3325-3327)cGg>cTg	p.R1109L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1109					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGAGCCAGCCGGGATTCCAGT	0.517000													45	171					3.54561e-26	3.56884e-26	1	1	0
LRRK1	79705	broad.mit.edu	37	15	101565044	101565044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101565044G>A	ENST00000284395.5	+	17	2495	c.2095G>A	c.(2095-2097)Gga>Aga	p.G699R	LRRK1_ENST00000388948.3_Missense_Mutation_p.G702R			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	702	Roc.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGACATCGGGGGACCGGCCAG	0.582000													38	213					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27458257	27458257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27458257C>T	ENST00000264705.4	+	24	4093	c.3931C>T	c.(3931-3933)Ccc>Tcc	p.P1311S	CAD_ENST00000403525.1_Missense_Mutation_p.P1248S	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1311	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CTTTAAGATCCCCAAGAAGAA	0.572000													14	108					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27411786	27411786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27411786G>A	ENST00000326799.3	-	12	1538	c.1390C>T	c.(1390-1392)Ctt>Ttt	p.L464F	YME1L1_ENST00000375972.3_Missense_Mutation_p.L374F|YME1L1_ENST00000376016.3_Missense_Mutation_p.L407F	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	464					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						ATTTCAGCAAGAAGTTGATTT	0.343000													30	66					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92734303	92734303	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92734303C>A	ENST00000379958.2	-	3	1377	c.1108G>T	c.(1108-1110)Gca>Tca	p.A370S		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	370						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTGGACTCTGCCAGTGTTTTA	0.338000													12	63					2.80697e-09	2.8176e-09	1	1	0
THBS1	7057	broad.mit.edu	37	15	39880361	39880361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39880361G>A	ENST00000260356.5	+	9	1578	c.1413G>A	c.(1411-1413)ggG>ggA	p.G471G		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	471	TSP type-1 2.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	AGATGAACGGGAAACCCTGTG	0.597000													10	93					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189869062	189869062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189869062G>A	ENST00000304636.3	+	40	3073	c.2903G>A	c.(2902-2904)aGg>aAg	p.R968K	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	968	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCAGGTCCTAGGGGAAGCCCT	0.522000													3	7					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8873709	8873709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:8873709G>A	ENST00000256707.3	-	29	4099	c.3918C>T	c.(3916-3918)cgC>cgT	p.R1306R	KIDINS220_ENST00000427284.1_Silent_p.R1287R|KIDINS220_ENST00000418530.1_Silent_p.R1207R|KIDINS220_ENST00000473731.1_Silent_p.R1287R	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1306					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GGGAAGCGCGGCGAGCAGGCT	0.597000													34	73					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64606904	64606904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64606904C>T	ENST00000498707.1	-	19	3041	c.2699G>A	c.(2698-2700)cGa>cAa	p.R900Q	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.R872Q	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	900	TSP type-1 2.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		AACAAGTTTTCGTTTCCGTTC	0.423000													12	26					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49210260	49210260	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:49210260G>A	ENST00000406846.2	-	7	689	c.570C>T	c.(568-570)ttC>ttT	p.F190F	FSHR_ENST00000469138.1_5'UTR|FSHR_ENST00000346173.3_Silent_p.F190F|FSHR_ENST00000541117.1_5'UTR|FSHR_ENST00000304421.4_Silent_p.F164F	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	190					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GGGTTCCATTGAATGCACAGT	0.373000									Gonadal Dysgenesis, 46 XX				14	57					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175049404	175049404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175049404C>T	ENST00000239462.4	+	4	1003	c.890C>T	c.(889-891)cCc>cTc	p.P297L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	297	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGCTACTACCCCCTGGGGAAG	0.577000													9	84					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52967192	52967192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52967192G>A	ENST00000549343.1	-	1	408	c.370C>T	c.(370-372)Ccc>Tcc	p.P124S	KRT74_ENST00000305620.2_Missense_Mutation_p.P124S			Q7RTS7	K2C74_HUMAN	keratin 74	124	Head.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		ACGTTGAGGGGGGCCAAGAGG	0.592000													21	122					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24581181	24581181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24581181C>T	ENST00000535378.1	-	8	1867	c.1225G>A	c.(1225-1227)Gga>Aga	p.G409R	KIAA0319_ENST00000543707.1_Missense_Mutation_p.G418R|KIAA0319_ENST00000430948.2_Missense_Mutation_p.G373R|KIAA0319_ENST00000378214.3_Missense_Mutation_p.G418R|KIAA0319_ENST00000537886.1_Missense_Mutation_p.G418R	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	418	PKD 1.				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						TTGACAAATCCTTCTCCAAAG	0.393000											OREG0017229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	140					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39134430	39134430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39134430G>A	ENST00000351578.6	-	9	1887	c.1697C>T	c.(1696-1698)gCt>gTt	p.A566V	FYB_ENST00000540520.1_Missense_Mutation_p.A576V|FYB_ENST00000515010.1_Missense_Mutation_p.A566V|FYB_ENST00000512982.1_Missense_Mutation_p.A566V|FYB_ENST00000505428.1_Missense_Mutation_p.A566V	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	566	SH3.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			AATCTCTACAGCAGTTGTTTT	0.323000													14	40					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130682871	130682871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130682871C>T	ENST00000510168.1	+	13	1506	c.956C>T	c.(955-957)gCt>gTt	p.A319V	ATP2C1_ENST00000508532.1_Missense_Mutation_p.A319V|ATP2C1_ENST00000504381.1_Missense_Mutation_p.A264V|ATP2C1_ENST00000359644.3_Missense_Mutation_p.A319V|ATP2C1_ENST00000393221.4_Missense_Mutation_p.A353V|ATP2C1_ENST00000428331.2_Missense_Mutation_p.A319V|ATP2C1_ENST00000422190.2_Missense_Mutation_p.A319V|ATP2C1_ENST00000504948.1_Missense_Mutation_p.A303V|ATP2C1_ENST00000505330.1_Missense_Mutation_p.A303V|ATP2C1_ENST00000507488.2_Missense_Mutation_p.A303V|ATP2C1_ENST00000328560.8_Missense_Mutation_p.A319V|ATP2C1_ENST00000533801.2_Missense_Mutation_p.A314V|ATP2C1_ENST00000513801.1_Missense_Mutation_p.A303V			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	319					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	GTGACGCTAGCTCTTGGTGTT	0.403000									Hailey-Hailey disease				70	150					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563283	140563283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140563283C>T	ENST00000361016.2	+	1	2304	c.1149C>T	c.(1147-1149)tcC>tcT	p.S383S		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		383	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGACGATTTCCTCCATCCAGG	0.483000													15	95					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25440076	25440076	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25440076G>A	ENST00000424208.1	+	0	1460				SNHG14_ENST00000456576.1_RNA|SNORD115-14_ENST00000363090.1_RNA	NR_003305.1																						TTGGGTCGATGATGAGAAACT	0.522000													108	249					0	0	1	0	0
ZNF100	163227	broad.mit.edu	37	19	21910476	21910476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21910476G>A	ENST00000358296.6	-	5	836	c.638C>T	c.(637-639)tCa>tTa	p.S213L	ZNF100_ENST00000305570.6_Missense_Mutation_p.S149L	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						CATGCAAAATGATTTTTCACA	0.308000													23	58					0	0	1	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565296	18565296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18565296G>A	ENST00000545289.1	-	5	1773	c.1523C>T	c.(1522-1524)tCa>tTa	p.S508L		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						GATGAGAGATGAACTGCACTT	0.363000													18	27					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15758113	15758113	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15758113T>A	ENST00000221307.7	+	5	552	c.504T>A	c.(502-504)aaT>aaA	p.N168K	CYP4F3_ENST00000586182.1_Missense_Mutation_p.N168K|CYP4F3_ENST00000585846.1_Missense_Mutation_p.N168K|CYP4F3_ENST00000591058.1_Missense_Mutation_p.N168K	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	168					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						AGATTTTCAATGAGAGTGTGA	0.507000													24	167					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6222303	6222303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6222303C>T	ENST00000264870.3	-	8	1340	c.1075G>A	c.(1075-1077)Ggg>Agg	p.G359R		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	359					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TTCACGTTCCCATCTTCTTCC	0.393000													20	48					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113704124	113704124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113704124G>A	ENST00000374431.3	-	4	753	c.370C>T	c.(370-372)Cgt>Tgt	p.R124C	LPAR1_ENST00000538760.1_Missense_Mutation_p.R125C|LPAR1_ENST00000541779.1_Missense_Mutation_p.R125C|LPAR1_ENST00000374430.2_Missense_Mutation_p.R124C|LPAR1_ENST00000358883.4_Missense_Mutation_p.R124C	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	124					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						AGGCCCTGACGAAGGAGCCAT	0.527000													36	109					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26517895	26517895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26517895C>T	ENST00000456354.2	+	2	398	c.331C>T	c.(331-333)Ctc>Ttc	p.L111F		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	111					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CACCATCGCTCTCCGTACCAA	0.597000													17	40					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209784817	209784817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209784817G>A	ENST00000009105.1	+	10	1080	c.835G>A	c.(835-837)Gga>Aga	p.G279R	CAMK1G_ENST00000494990.1_3'UTR|CAMK1G_ENST00000361322.2_Missense_Mutation_p.G279R			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	279	Autoinhibitory domain (By similarity).					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		CAGGATTGACGGAAACACAGC	0.562000													5	24					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114154814	114154814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:114154814C>T	ENST00000393081.1	+	2	417	c.110C>T	c.(109-111)cCc>cTc	p.P37L	ACSL5_ENST00000433418.1_Missense_Mutation_p.P37L|ACSL5_ENST00000479936.1_3'UTR|ACSL5_ENST00000356116.1_Missense_Mutation_p.P93L|ACSL5_ENST00000354273.4_Missense_Mutation_p.P37L|ACSL5_ENST00000354655.4_Missense_Mutation_p.P37L	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	37					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		AGACCTCAACCCGTCTTACCT	0.448000													31	91					0	0	1	0	0
CD38	952	broad.mit.edu	37	4	15780251	15780251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:15780251G>A	ENST00000226279.2	+	1	351	c.214G>A	c.(214-216)Gaa>Aaa	p.E72K		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	72					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						CAAGTACACTGAAATTCATCC	0.692000													22	37					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55501474	55501474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55501474C>T	ENST00000543010.1	+	9	2594	c.2451C>T	c.(2449-2451)aaC>aaT	p.N817N	NLRP2_ENST00000339757.7_Silent_p.N795N|NLRP2_ENST00000391721.4_Silent_p.N793N|NLRP2_ENST00000427260.2_Silent_p.N794N|NLRP2_ENST00000538819.1_Silent_p.N793N|NLRP2_ENST00000263437.6_Silent_p.N814N|NLRP2_ENST00000537859.1_Silent_p.N795N|NLRP2_ENST00000448584.2_Silent_p.N817N	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	817					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CGTGCGTAAACCTCTCCGACA	0.522000													35	79					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12225854	12225854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12225854C>T	ENST00000256194.4	+	4	610	c.322C>T	c.(322-324)Ctg>Ttg	p.L108L	MICAL2_ENST00000527195.1_3'UTR|MICAL2_ENST00000379612.3_Silent_p.L108L|MICAL2_ENST00000342902.5_Silent_p.L108L|MICAL2_ENST00000527546.1_Silent_p.L108L|MICAL2_ENST00000537344.1_Silent_p.L108L	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	108						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		ACTTGCCTACCTGGGAGCCAA	0.572000													10	57					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12184911	12184911	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12184911T>A	ENST00000439326.3	+	2	244	c.69T>A	c.(67-69)ccT>ccA	p.P23P	ZNF844_ENST00000441304.2_Silent_p.P23P	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	23	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TGCTGGATCCTTCCCAGAAGA	0.493000													41	103					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45355503	45355503	+	Splice_Site	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45355503T>G	ENST00000359271.2	+	3	1539	c.1288_splice	c.e3-1	p.V430_splice		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	430						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				CCCACCCTAGTGACCTGGCTT	0.577000													28	131					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83675644	83675644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83675644G>A	ENST00000265362.3	-	6	977	c.663C>T	c.(661-663)ctC>ctT	p.L221L	SEMA3A_ENST00000436949.1_Silent_p.L221L	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	221	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						ACCTACCATTGAGCCACCTGG	0.423000													53	113					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8167710	8167710	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:8167710G>A	ENST00000402384.3	-	13	1389	c.1123C>T	c.(1123-1125)Ctg>Ttg	p.L375L	ICA1_ENST00000422063.2_Silent_p.L404L|ICA1_ENST00000396675.3_Silent_p.L375L|ICA1_ENST00000265577.7_Silent_p.L374L|ICA1_ENST00000401396.1_Silent_p.L363L|ICA1_ENST00000406470.2_Silent_p.L375L			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	375					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TCACTCAACAGCAGCAGGTCA	0.552000													33	170					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	63963095	63963095	+	Nonsense_Mutation	SNP	G	G	A	rs2942671		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:63963095G>A	ENST00000324472.4	-	21	2218	c.2035C>T	c.(2035-2037)Cga>Tga	p.R679*	DPY19L2_ENST00000413230.2_Nonsense_Mutation_p.R126*	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	679					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		GCAGATTTTCGACTATATGTA	0.264000													31	102					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129030435	129030435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:129030435C>T	ENST00000274487.4	+	19	2968	c.2823C>T	c.(2821-2823)tcC>tcT	p.S941S	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	941	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CAACAGTGTCCTGCACAAAAA	0.348000													22	72					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77476765	77476765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77476765G>A	ENST00000296043.6	+	2	1125	c.172G>A	c.(172-174)Gaa>Aaa	p.E58K		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	58	PDZ.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			CAAGCAGGTCGAAGAAGGGGG	0.602000													14	44					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141740591	141740591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141740591C>T	ENST00000475668.2	+	21	2497	c.2443C>T	c.(2443-2445)Ctt>Ttt	p.L815F	MGAM_ENST00000549489.2_Missense_Mutation_p.L815F			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	815	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGGACTTCACCTTCGAGGAGG	0.478000													16	38					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637506	248637506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248637506C>T	ENST00000359594.2	+	1	880	c.855C>T	c.(853-855)atC>atT	p.I285I		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTACACCATCTTCACTCCTG	0.502000													69	322					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38620858	38620858	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38620858C>T	ENST00000413689.1	-	18	3550	c.3357G>A	c.(3355-3357)tgG>tgA	p.W1119*	SCN5A_ENST00000423572.2_Nonsense_Mutation_p.W1118*|SCN5A_ENST00000425664.1_Nonsense_Mutation_p.W1119*|SCN5A_ENST00000333535.4_Nonsense_Mutation_p.W1119*|SCN5A_ENST00000451551.2_Intron|SCN5A_ENST00000455624.2_Nonsense_Mutation_p.W1118*|SCN5A_ENST00000449557.2_Intron|SCN5A_ENST00000450102.2_Intron|SCN5A_ENST00000443581.1_Nonsense_Mutation_p.W1118*|SCN5A_ENST00000414099.2_Nonsense_Mutation_p.W1119*	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1119					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTTCCGCTTTCCACTGCTGCC	0.662000													3	12					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43547288	43547288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43547288G>A	ENST00000400427.1	+	18	4030	c.3634G>A	c.(3634-3636)Gag>Aag	p.E1212K	UMODL1_ENST00000400423.2_3'UTR|UMODL1_ENST00000408989.2_Missense_Mutation_p.E1284K|UMODL1_ENST00000400424.1_Missense_Mutation_p.E1084K|UMODL1_ENST00000408910.2_Missense_Mutation_p.E1156K	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	1156	ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						GGTCCTGACGGAGTGCTGGGC	0.567000													31	64					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803596	185803596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185803596G>A	ENST00000302277.6	+	4	4067	c.3473G>A	c.(3472-3474)gGg>gAg	p.G1158E		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1158						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CTTTGTCCTGGGAACCAGCCA	0.512000													60	131					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18715720	18715720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18715720C>T	ENST00000433979.1	+	26	3667	c.3551C>T	c.(3550-3552)cCt>cTt	p.P1184L	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.P1184L|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.P1225L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1184					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GCCATAAGCCCTGCCAAATCT	0.393000													4	14					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10942755	10942755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10942755C>T	ENST00000298232.7	-	12	999	c.632G>A	c.(631-633)cGa>cAa	p.R211Q	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.R191Q|TPTE_ENST00000361285.4_Missense_Mutation_p.R229Q	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	229					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCTTGTGTATCGCCTTTTGTT	0.323000													65	441					0	0	1	0	0
SF3A1	10291	broad.mit.edu	37	22	30742459	30742459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30742459G>A	ENST00000439242.1	-	3	366	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	SF3A1_ENST00000215793.7_Missense_Mutation_p.P79S	NM_001005409.1	NP_001005409.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	79					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						TTGAACTTGGGGTTGTTGATC	0.517000													38	115					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6731105	6731105	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6731105G>A	ENST00000264080.7	-	17	1478	c.1452C>T	c.(1450-1452)tcC>tcT	p.S484S	GPR108_ENST00000430424.4_Silent_p.S242S|GPR108_ENST00000598626.1_Intron	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	484						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						AGGCCAGGGTGGAGCCCTCCA	0.697000													13	31					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40313113	40313113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40313113C>T	ENST00000263791.5	+	31	4230	c.4187C>T	c.(4186-4188)tCt>tTt	p.S1396F	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.S1368F	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1396	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		ACAATAAGCTCTTGTGACCTC	0.507000													27	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604474	179604474	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179604474G>A	ENST00000589042.1	-	48	13710	c.13486C>T	c.(13486-13488)Cag>Tag	p.Q4496*	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Nonsense_Mutation_p.Q4179*|TTN_ENST00000342175.6_Nonsense_Mutation_p.Q4325*|TTN_ENST00000359218.5_Nonsense_Mutation_p.Q4258*|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.Q4133*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4179	Ig-like 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCCTTGCTGAATTCTAGGA	0.383000													86	191					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48452052	48452052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48452052G>A	ENST00000435803.1	+	41	12355	c.12331G>A	c.(12331-12333)Gag>Aag	p.E4111K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4111					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CAGTGGAAGTGAGCTGACCTA	0.493000													18	44					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55406589	55406589	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55406589A>T	ENST00000398661.2	-	4	456	c.325T>A	c.(325-327)Tcc>Acc	p.S109T	HMGCLL1_ENST00000308161.4_Missense_Mutation_p.S79T|HMGCLL1_ENST00000508459.1_Missense_Mutation_p.S79T|HMGCLL1_ENST00000274901.4_Missense_Mutation_p.S79T|HMGCLL1_ENST00000428842.1_Missense_Mutation_p.S79T|HMGCLL1_ENST00000370850.2_Missense_Mutation_p.S79T	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	109							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCAGTTTGGGAAAGTCGATTG	0.313000													42	82					0	0	1	0	0
HMGB1P5	10354	broad.mit.edu	37	3	22424080	22424080	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:22424080C>T	ENST00000451497.1	+	0	645																											TGTACAGTGTCTTTTTTTGTA	0.363000													10	22					0	0	1	0	0
KAT8	84148	broad.mit.edu	37	16	31131550	31131550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31131550C>T	ENST00000543774.2	+	3	590	c.255C>T	c.(253-255)ggC>ggT	p.G85G	KAT8_ENST00000448516.2_Silent_p.G85G|KAT8_ENST00000219797.4_Silent_p.G85G			Q9H7Z6	MYST1_HUMAN	K(lysine) acetyltransferase 8	85	Chromo.				histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding										ACCAGGAGGGCCGAGAGGAAT	0.547000													41	105					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17592160	17592160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17592160C>T	ENST00000375460.3	+	4	393	c.353C>T	c.(352-354)tCt>tTt	p.S118F		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	118					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GCAGACATCTCTCTGGATTGC	0.567000													40	84					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74044075	74044075	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74044075G>A	ENST00000409561.1	+	3	2846	c.2725G>A	c.(2725-2727)Gaa>Aaa	p.E909K		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	909										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						CATTGAAAGGGAAAGAGATAT	0.423000													5	16					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74365888	74365888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74365888C>T	ENST00000226355.3	+	12	1683	c.1590C>T	c.(1588-1590)acC>acT	p.T530T		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	530	Albumin 3.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ATTTATTTACCTTTCACGCAG	0.393000													7	60					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69335027	69335027	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:69335027C>T	ENST00000260364.5	+	11	1776	c.1475C>T	c.(1474-1476)tCc>tTc	p.S492F	NOX5_ENST00000448182.3_Missense_Mutation_p.S464F|NOX5_ENST00000530406.2_Missense_Mutation_p.S482F|NOX5_ENST00000455873.3_Missense_Mutation_p.S475F|NOX5_ENST00000388866.3_Missense_Mutation_p.S510F|RP11-809H16.4_ENST00000559495.1_RNA			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	510	C-terminal catalytic region.|FAD-binding FR-type.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CACATTCGGTCCCAAGGCCAG	0.557000													13	73					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45297465	45297465	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45297465C>T	ENST00000270279.3	+	9	1352	c.1289C>T	c.(1288-1290)cCc>cTc	p.P430L	CBLC_ENST00000341505.4_Missense_Mutation_p.P384L	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	430					cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				CCCCAGGTGCCCCTTTCGGCT	0.612000			M		AML								40	204					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62398280	62398280	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62398280G>A	ENST00000346178.4	-	12	1260	c.1245C>T	c.(1243-1245)tcC>tcT	p.S415S	GANAB_ENST00000534779.1_Silent_p.S301S|GANAB_ENST00000356638.3_Silent_p.S393S|GANAB_ENST00000540933.1_Silent_p.S296S	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	393					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GGTAGCCGAGGGAGAAGAGTG	0.582000													7	22					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229917	21229917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21229917G>A	ENST00000233242.1	-	26	9950	c.9823C>T	c.(9823-9825)Cca>Tca	p.P3275S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3275					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACTGCTTTTGGGAACACATAG	0.478000													16	49					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168819864	168819864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168819864C>T	ENST00000464456.1	-	9	3364	c.2164G>A	c.(2164-2166)Gag>Aag	p.E722K	MECOM_ENST00000433243.2_Missense_Mutation_p.E732K|MECOM_ENST00000472280.1_Missense_Mutation_p.E732K|MECOM_ENST00000392736.3_Missense_Mutation_p.E731K|MECOM_ENST00000494292.1_Missense_Mutation_p.E910K|MECOM_ENST00000468789.1_Missense_Mutation_p.E731K|MECOM_ENST00000264674.3_Missense_Mutation_p.E796K|MECOM_ENST00000460814.1_Missense_Mutation_p.E722K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GTATAGCGCTCCTTTCCCTTC	0.483000													13	43					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25701888	25701888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:25701888C>T	ENST00000349320.3	-	10	1445	c.1057G>A	c.(1057-1059)Gaa>Aaa	p.E353K	RHCE_ENST00000455194.1_Missense_Mutation_p.E264K|RHCE_ENST00000425135.1_Missense_Mutation_p.G278E|RHCE_ENST00000374352.2_Missense_Mutation_p.E353K|RHCE_ENST00000413854.1_Intron|RHCE_ENST00000346452.4_Missense_Mutation_p.E218K|RHCE_ENST00000349438.4_Missense_Mutation_p.G324E|RHCE_ENST00000340849.4_Intron|RHCE_ENST00000243186.6_Intron|RHCE_ENST00000294413.7_Missense_Mutation_p.E369K			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	369						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		AAGCTGAGTTCCCCAATGCTG	0.547000													45	172					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79314691	79314691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79314691G>A	ENST00000305089.3	-	2	128	c.48C>T	c.(46-48)ttC>ttT	p.F16F		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	16					cell proliferation	extracellular region	sugar binding	p.F16L(2)		central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						TCAGAGACAGGAACATCAGGG	0.473000													16	33					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164507064	164507064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164507064C>T	ENST00000503008.1	-	6	1236	c.260G>A	c.(259-261)gGg>gAg	p.G87E	MARCH1_ENST00000274056.7_Missense_Mutation_p.G87E|MARCH1_ENST00000514618.1_Missense_Mutation_p.G343E|MARCH1_ENST00000339875.5_Missense_Mutation_p.G70E	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	87					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CTCTTCATCCCCTTCGCAGTG	0.522000													12	35					0	0	1	0	0
TM4SF20	79853	broad.mit.edu	37	2	228235632	228235632	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228235632C>T	ENST00000304568.3	-	2	285	c.249_splice	c.e2+1	p.G83_splice		NM_024795.3	NP_079071.2	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	83						integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(2)	10		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		CATACTTACTCCAGTTCTGTT	0.448000													151	369					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9034648	9034648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9034648C>T	ENST00000383836.3	-	20	2927	c.2500G>A	c.(2500-2502)Gac>Aac	p.D834N	SRGAP3_ENST00000360413.3_Missense_Mutation_p.D810N	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	834					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GACTGGAGGTCGTTTTTGGAA	0.582000			T	RAF1	pilocytic astrocytoma								20	64					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52569430	52569430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52569430G>A	ENST00000389534.4	-	7	2164	c.1705C>T	c.(1705-1707)Ctc>Ttc	p.L569F	ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000359973.2_Intron|ZNF841_ENST00000594295.1_Missense_Mutation_p.L569F|ZNF841_ENST00000426391.2_Missense_Mutation_p.L453F	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						TTACAATGGAGAGGTTTCTCT	0.403000													19	68					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71130426	71130426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:71130426C>T	ENST00000333538.5	+	7	1745	c.1111C>T	c.(1111-1113)Ctt>Ttt	p.L371F	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	371	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CATGGAGGTCCTTCCTTGCTC	0.522000													38	123					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75991451	75991451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75991451C>T	ENST00000274364.6	+	32	4463	c.4166C>T	c.(4165-4167)tCc>tTc	p.S1389F	IQGAP2_ENST00000396234.3_Missense_Mutation_p.S885F|CTD-2384B11.2_ENST00000507514.1_RNA|IQGAP2_ENST00000502745.1_Missense_Mutation_p.S885F|IQGAP2_ENST00000379730.3_Missense_Mutation_p.S891F	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1389					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CACGTGTCATCCGAAAATAAA	0.418000													32	71					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70934981	70934981	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70934981C>T	ENST00000393567.2	-	53	9124	c.8974G>A	c.(8974-8976)Gag>Aag	p.E2992K		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2992										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TACTCAGCCTCAGGGGGGATG	0.572000													23	197					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197066061	197066061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197066061G>A	ENST00000260983.2	-	29	4841	c.4659C>T	c.(4657-4659)tcC>tcT	p.S1553S	HECW2_ENST00000409111.1_Silent_p.S1197S	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	1553	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CATAAAGCATGGAAAAGGATG	0.453000													34	83					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34002668	34002668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34002668G>A	ENST00000373381.4	-	62	10009	c.9833C>T	c.(9832-9834)cCt>cTt	p.P3278L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3134						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGCACACCAGGGTCCGCACA	0.517000													29	52					0	0	1	0	0
CUL4A	8451	broad.mit.edu	37	13	113909298	113909298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113909298C>T	ENST00000451881.1	+	18	1839	c.1590C>T	c.(1588-1590)tcC>tcT	p.S530S	CUL4A_ENST00000375441.3_Silent_p.S530S|CUL4A_ENST00000375440.4_Silent_p.S630S|CUL4A_ENST00000326335.4_Silent_p.S530S	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	630					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			CGCTGCAGTCCCTGGCCTGTG	0.458000													13	34					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248570362	248570362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248570362G>A	ENST00000366474.1	+	1	1067	c.1067G>A	c.(1066-1068)gGg>gAg	p.G356E		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	356					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGGCCTTGGGGAGGTTCAAG	0.522000													40	134					0	0	1	0	0
SLC17A9	63910	broad.mit.edu	37	20	61596512	61596512	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61596512C>T	ENST00000370349.3	+	10	1125	c.921C>T	c.(919-921)ctC>ctT	p.L307L	SLC17A9_ENST00000370351.4_Silent_p.L313L|SLC17A9_ENST00000488738.1_3'UTR			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	313					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						TGCGGAAGCTCATGCAGGTAG	0.577000													21	42					0	0	1	0	0
SIX3	6496	broad.mit.edu	37	2	45170038	45170038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:45170038G>A	ENST00000260653.3	+	1	1137	c.795G>A	c.(793-795)gcG>gcA	p.A265A		NM_005413.3	NP_005404.1	O95343	SIX3_HUMAN	SIX homeobox 3	265	Poly-Ala.				visual perception	nucleus				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|skin(1)	11		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GCGCCGCGGCGGCCAAGAACA	0.682000													12	16					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126208159	126208159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126208159C>T	ENST00000290868.2	-	17	1721	c.1668G>A	c.(1666-1668)agG>agA	p.R556R	UROC1_ENST00000383579.3_Silent_p.R616R	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	556					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		TGGAGGTCTCCCTAAAGGGGC	0.498000													37	141					0	0	1	0	0
SPINK7	84651	broad.mit.edu	37	5	147693683	147693683	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147693683G>A	ENST00000274565.4	+	3	169	c.108G>A	c.(106-108)aaG>aaA	p.K36K	SPINK7_ENST00000514394.1_3'UTR|RP11-373N22.3_ENST00000501695.3_RNA|SPINK7_ENST00000523535.1_Silent_p.K10K	NM_032566.2	NP_115955.1	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7 (putative)	36	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATTTACAAGAAGTATCCAG	0.473000													67	167					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97485093	97485093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:97485093C>T	ENST00000376705.2	+	2	1081	c.1057C>T	c.(1057-1059)Ctc>Ttc	p.L353F		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	353						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					CTTCTTTGGGCTCACTGAGTT	0.463000													31	79					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73678100	73678100	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73678100C>T	ENST00000264448.6	+	8	4554	c.4443C>T	c.(4441-4443)ccC>ccT	p.P1481P	ALMS1_ENST00000409009.1_Silent_p.P1439P|ALMS1_ENST00000377715.1_Silent_p.P1481P	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1481	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GAGAGAAGCCCATTGTTATCT	0.507000													65	131					0	0	1	0	0
FCGRT	2217	broad.mit.edu	37	19	50027802	50027802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50027802C>T	ENST00000221466.5	+	5	1126	c.640C>T	c.(640-642)Cct>Tct	p.P214S	FCGRT_ENST00000599988.1_Intron|FCGRT_ENST00000594823.1_3'UTR|FCGRT_ENST00000596975.1_Missense_Mutation_p.P122S|FCGRT_ENST00000426395.3_Missense_Mutation_p.P214S	NM_001136019.2	NP_001129491.1	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	214	Alpha-3.				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			endometrium(3)|kidney(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	9		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		ACCCAGCAGCCCTGGCTTTTC	0.667000													27	86					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066278	73066278	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73066278G>A	ENST00000429829.1	-	0	6310					NR_001564.2																						GATCCCAGACGATTATAATCA	0.488000													27	19					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203680140	203680140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203680140C>T	ENST00000357681.5	+	12	3058	c.1935C>T	c.(1933-1935)ttC>ttT	p.F645F	ATP2B4_ENST00000391954.2_Silent_p.F645F|ATP2B4_ENST00000367219.3_Silent_p.F633F|ATP2B4_ENST00000341360.2_Silent_p.F645F|ATP2B4_ENST00000367218.3_Silent_p.F645F	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	645					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding	p.F645fs*18(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ACCGGGACTTCGATGACACAG	0.532000													36	94					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	156956528	156956528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:156956528C>T	ENST00000348165.5	+	2	451	c.91C>T	c.(91-93)Cgt>Tgt	p.R31C	UBE3C_ENST00000389103.4_Intron	NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	31	Cis-determinant of acceptor ubiquitin- binding.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TCTTTTACATCGTACTCAGGA	0.328000													30	75					0	0	1	0	0
CCR2	729230	broad.mit.edu	37	3	46399344	46399344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46399344G>A	ENST00000292301.4	+	2	811	c.326G>A	c.(325-327)gGg>gAg	p.G109E	CCR2_ENST00000465202.1_Intron|CCR2_ENST00000445132.2_Missense_Mutation_p.G109E|CCR2_ENST00000400888.2_Missense_Mutation_p.G109E	NM_001123041.2	NP_001116513.2	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2	109					astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			breast(3)|endometrium(1)|large_intestine(1)|liver(2)|lung(7)	14				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		TGGGTCTTTGGGAATGCAATG	0.438000													102	245					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325338	150325338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150325338G>A	ENST00000493969.1	-	3	301	c.124C>T	c.(124-126)Cgt>Tgt	p.R42C	GIMAP6_ENST00000328902.5_Silent_p.I116I	NM_001244071.1	NP_001231000.1	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	284							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGATAAGACGATGGCTTGGC	0.632000													23	76					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	170008397	170008397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:170008397G>A	ENST00000367765.1	-	4	1733	c.232C>T	c.(232-234)Cca>Tca	p.P78S	KIFAP3_ENST00000367767.1_Missense_Mutation_p.P74S|KIFAP3_ENST00000490550.1_5'UTR|KIFAP3_ENST00000538366.1_Missense_Mutation_p.P40S|KIFAP3_ENST00000361580.2_Missense_Mutation_p.P118S	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	118					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AAAGGAGGTGGATCTTTAGGC	0.313000													12	22					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46772028	46772028	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:46772028C>T	ENST00000394809.4	-	3	711	c.596G>A	c.(595-597)gGg>gAg	p.G199E	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	199				G -> R (in Ref. 1; CAC42766).	cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CTCCGCTGTCCCCTCCAGCAC	0.617000													3	9					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25479220	25479220	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25479220G>A	ENST00000453082.2	+	0	1761					NR_003343.1																						GAGCCTGGAGGAAGACTCGTG	0.577000													9	12					0	0	1	0	0
PROM1	8842	broad.mit.edu	37	4	15991445	15991445	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:15991445G>A	ENST00000505450.1	-	18	2571	c.1959C>T	c.(1957-1959)ccC>ccT	p.P653P	PROM1_ENST00000510224.1_Silent_p.P662P|PROM1_ENST00000447510.2_Silent_p.P662P|PROM1_ENST00000540805.1_Silent_p.P662P|PROM1_ENST00000543373.1_Silent_p.P653P|PROM1_ENST00000539194.1_Silent_p.P662P|PROM1_ENST00000508167.1_Silent_p.P653P	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	662					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						AATTTCCTGGGGGCTACAAAA	0.438000													3	7					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61262370	61262370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61262370C>T	ENST00000344731.5	+	7	825	c.723C>T	c.(721-723)gaC>gaT	p.D241D	SERPINB13_ENST00000269489.5_Intron	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	241					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						AAAACAACGACCTAAGCATGT	0.428000													41	108					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236902620	236902620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236902620C>T	ENST00000366578.4	+	10	1061	c.895C>T	c.(895-897)Cgc>Tgc	p.R299C	ACTN2_ENST00000542672.1_Missense_Mutation_p.R299C|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_Intron	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	299					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			ATGGATTCGTCGCACGATCCC	0.527000													50	145					0	0	1	0	0
CD27	939	broad.mit.edu	37	12	6554368	6554368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6554368G>A	ENST00000266557.3	+	1	336	c.107G>A	c.(106-108)gGa>gAa	p.G36E	CD27-AS1_ENST00000545339.1_RNA|CD27-AS1_ENST00000399492.2_RNA	NM_001242.4	NP_001233.1	P26842	CD27_HUMAN	CD27 molecule	36					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						TGGGCTCAGGGAAAGCTGTGC	0.602000													5	19					0	0	1	0	0
INS-IGF2	723961	broad.mit.edu	37	11	2170415	2170415	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2170415G>A	ENST00000397270.1	-	3	406	c.348C>T	c.(346-348)tcC>tcT	p.S116S	IGF2_ENST00000300632.5_5'UTR|INS-IGF2_ENST00000481781.1_5'UTR	NM_001042376.2	NP_001035835.1	Q1WM24	Q1WM24_HUMAN		116					glucose metabolic process	extracellular region	hormone activity			haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	5		all_epithelial(84;0.00018)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.0832)|Lung(200;0.156)		AGAGGACCGGGGAGTCACTGG	0.602000													45	94					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13534810	13534810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:13534810C>T	ENST00000341083.3	-	5	778	c.482G>A	c.(481-483)cGa>cAa	p.R161Q	BEND7_ENST00000396898.2_Missense_Mutation_p.R226Q|BEND7_ENST00000396900.2_Missense_Mutation_p.R213Q|BEND7_ENST00000378605.3_Missense_Mutation_p.R174Q	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	213							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						ATTTCTCTTTCGTGAGACAGC	0.433000													31	114					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65319621	65319621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65319621G>A	ENST00000301873.5	-	8	1621	c.1353C>T	c.(1351-1353)ttC>ttT	p.F451F	LTBP3_ENST00000536982.1_Silent_p.F77F|LTBP3_ENST00000322147.4_Silent_p.F451F	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	451	TB 2.					extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						AGATCTCCTTGAACGCAGCTG	0.557000											OREG0021081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	94					0	0	1	0	0
DAO	1610	broad.mit.edu	37	12	109293228	109293228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109293228C>T	ENST00000228476.3	+	10	1093	c.889C>T	c.(889-891)Cgc>Tgc	p.R297C	DAO_ENST00000551281.1_Missense_Mutation_p.R231C	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	297					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						AGAACAGCTTCGCACTGGACC	0.498000													15	29					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621389	179621389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179621389G>A	ENST00000589042.1	-	46	11038	c.10814C>T	c.(10813-10815)tCa>tTa	p.S3605L	TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Missense_Mutation_p.S3434L|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3291							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATTCATATGATGATCCTTG	0.418000													21	55					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26581740	26581740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26581740C>T	ENST00000252992.4	+	4	418	c.287C>T	c.(286-288)cCt>cTt	p.P96L	CEP85_ENST00000451429.2_Missense_Mutation_p.P45L	NM_022778.2	NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	96						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						CATGTGATGCCTTCTACTTTA	0.498000													124	282					0	0	1	0	0
TLX1NB	100038246	broad.mit.edu	37	10	102849587	102849587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102849587C>T	ENST00000445873.1	-	3	1352	c.76G>A	c.(76-78)Gag>Aag	p.E26K		NM_001085398.1	NP_001078867.1	P0CAT3	TLXNB_HUMAN	TLX1 neighbor	26																	CCCATGGCCTCTTGGGAAAGG	0.657000													3	15					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176853515	176853515	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176853515C>T	ENST00000367654.2	-	19	3223	c.3210G>A	c.(3208-3210)gaG>gaA	p.E1070E	ASTN1_ENST00000424564.2_Silent_p.E1062E|ASTN1_ENST00000367657.3_Silent_p.E1062E|ASTN1_ENST00000361833.2_Silent_p.E1062E			O14525	ASTN1_HUMAN	astrotactin 1	1070	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CAGTGACTTTCTCTTGACGGA	0.507000													30	75					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60164109	60164109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60164109G>A	ENST00000300187.6	+	1	335	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K	MS4A14_ENST00000395005.2_Missense_Mutation_p.E20K|MS4A14_ENST00000531783.1_Missense_Mutation_p.E20K|MS4A14_ENST00000395001.1_5'UTR|MS4A14_ENST00000531787.1_Intron	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	20						integral to membrane	receptor activity	p.E20Q(1)		autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						AAAACCAAACGAAACTGTATT	0.458000													12	32					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12364652	12364652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12364652C>T	ENST00000358136.3	+	26	6436	c.6306C>T	c.(6304-6306)tcC>tcT	p.S2102S	VPS13D_ENST00000356315.4_Silent_p.S2102S	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2102					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GAACCCATTCCCAGGGGCAGT	0.567000													22	61					0	0	1	0	0
C1orf65	164127	broad.mit.edu	37	1	223567678	223567678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:223567678G>A	ENST00000366875.3	+	1	964	c.861G>A	c.(859-861)ctG>ctA	p.L287L		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	287										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		GGGAGGAGCTGAAGCGCTCGG	0.657000													3	9					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147236	26147236	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:26147236T>A	ENST00000331351.5	+	2	1430	c.1038T>A	c.(1036-1038)taT>taA	p.Y346*	HS3ST4_ENST00000475436.1_3'UTR	NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	346					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		GGCTCCAGTATTTCCCCCTCT	0.542000													61	128					0	0	1	0	0
ACADSB	36	broad.mit.edu	37	10	124793927	124793927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124793927C>T	ENST00000358776.4	+	2	112	c.98C>T	c.(97-99)tCa>tTa	p.S33L	ACADSB_ENST00000368869.4_5'UTR|ACADSB_ENST00000496730.2_3'UTR	NM_001609.3	NP_001600.1	P45954	ACDSB_HUMAN	acyl-CoA dehydrogenase, short/branched chain	33					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	CCTCATGTCTCAAAATCTTCC	0.363000													8	103					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18828563	18828563	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:18828563G>A	ENST00000396576.2	+	13	2229	c.1728G>A	c.(1726-1728)aaG>aaA	p.K576K	CACNB2_ENST00000377331.2_Silent_p.K579K|CACNB2_ENST00000324631.7_Silent_p.K631K|CACNB2_ENST00000352115.6_Silent_p.K607K|CACNB2_ENST00000282343.8_Silent_p.K603K|RP11-499P20.2_ENST00000425669.1_RNA|CACNB2_ENST00000377319.3_Silent_p.K538K|CACNB2_ENST00000377328.1_Silent_p.K381K|CACNB2_ENST00000377315.4_Silent_p.K583K|CACNB2_ENST00000377329.4_Silent_p.K577K	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	631					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATAAATCCAAGGATCGCTACT	0.537000													9	84					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103055700	103055700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103055700C>T	ENST00000375735.2	+	41	6697	c.6553C>T	c.(6553-6555)Cat>Tat	p.H2185Y	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.H2185Y	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2185					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTGCAGAGATCATGACGAATT	0.363000													23	67					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153864301	153864301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:153864301C>T	ENST00000511601.1	+	2	280	c.92C>T	c.(91-93)cCt>cTt	p.P31L	FHDC1_ENST00000260008.3_Missense_Mutation_p.P31L			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	31					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					CAGAcacctcctccagcacct	0.517000													15	62					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29527590	29527590	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:29527590C>T	ENST00000358273.4	+	9	1422	c.1039C>T	c.(1039-1041)Cag>Tag	p.Q347*	NF1_ENST00000431387.4_Nonsense_Mutation_p.Q347*|NF1_ENST00000356175.3_Nonsense_Mutation_p.Q347*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	347					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CCTACTTGTTCAGTCCATGGT	0.348000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			42	62					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246829020	246829020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:246829020C>T	ENST00000366513.4	+	11	2260	c.1991C>T	c.(1990-1992)tCc>tTc	p.S664F		NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	664					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						GGAGGTGGCTCCTGTATTTTG	0.428000													28	64					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38139114	38139114	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38139114G>A	ENST00000308059.6	+	17	2572	c.2551G>A	c.(2551-2553)Gag>Aag	p.E851K	DLEC1_ENST00000452631.2_Missense_Mutation_p.E851K|DLEC1_ENST00000346219.3_Missense_Mutation_p.E851K			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	851					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GTTACACATTGAGGCTGTCTT	0.602000													23	31					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21370127	21370127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21370127C>T	ENST00000256958.2	+	12	1668	c.1572C>T	c.(1570-1572)tgC>tgT	p.C524C		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	524					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TGGGTGAATGCCCAAGAGATG	0.383000													24	53					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160721269	160721269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:160721269C>T	ENST00000274547.2	-	11	1575	c.1358G>A	c.(1357-1359)cGa>cAa	p.R453Q	GABRB2_ENST00000517901.1_Missense_Mutation_p.R352Q|GABRB2_ENST00000353437.6_Missense_Mutation_p.R415Q|GABRB2_ENST00000517547.1_Missense_Mutation_p.R255Q|GABRB2_ENST00000393959.1_Missense_Mutation_p.R453Q|GABRB2_ENST00000520240.1_Missense_Mutation_p.R415Q	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	453					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAGAGCATTTCGGCCAAAACT	0.532000													29	61					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28805325	28805325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:28805325G>A	ENST00000422425.2	+	24	1697	c.1653G>A	c.(1651-1653)agG>agA	p.R551R	PLB1_ENST00000329020.6_Silent_p.R250R|PLB1_ENST00000327757.5_Silent_p.R562R	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	562	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TCAACCTGAGGGAGCTGTACC	0.517000													5	12					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182026425	182026425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:182026425C>T	ENST00000339948.3	-	2	928	c.721G>A	c.(721-723)Gag>Aag	p.E241K		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						TCTCCGCCCTCGCGCCGGCCC	0.731000													4	11					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111542474	111542474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111542474G>A	ENST00000354925.2	-	6	1941	c.236C>T	c.(235-237)cCg>cTg	p.P79L	PITX2_ENST00000394595.3_Intron|PITX2_ENST00000306732.3_Missense_Mutation_p.P86L|PITX2_ENST00000557119.2_Missense_Mutation_p.P86L|PITX2_ENST00000355080.5_Missense_Mutation_p.P33L|PITX2_ENST00000394598.2_Missense_Mutation_p.P79L	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	79					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CTTCTTAGACGGGTCCTCGGC	0.577000													7	109					0	0	1	0	0
ACOT7	11332	broad.mit.edu	37	1	6445578	6445578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6445578G>A	ENST00000377855.2	-	1	295	c.149C>T	c.(148-150)cCc>cTc	p.P50L	ACOT7_ENST00000545482.1_Intron|ACOT7_ENST00000361521.4_Intron	NM_181864.2	NP_863654.1	O00154	BACH_HUMAN	acyl-CoA thioesterase 7	50						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity			kidney(1)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	16	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		GGCTCCACAGGGTGGGAGATC	0.652000													47	156					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47607787	47607787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47607787C>T	ENST00000371891.3	+	4	421	c.390C>T	c.(388-390)ggC>ggT	p.G130G	CYP4A22_ENST00000371890.3_Silent_p.G130G|CYP4A22_ENST00000294337.3_Silent_p.G130G|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000485117.1_3'UTR	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	130			G -> S (in allele CYP4A22*4, allele CYP4A22*10, allele CYP4A22*12, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15; dbSNP:rs2056900).			endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TAGGGTACGGCTTGCTCCTGT	0.537000													30	40					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97852271	97852271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97852271C>T	ENST00000354565.2	+	1	730	c.730C>T	c.(730-732)Cat>Tat	p.H244Y	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						CTGTGGAGCCCATCTCTTCTC	0.408000													50	127					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46945084	46945084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46945084G>A	ENST00000313049.5	+	14	1923	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	PTH1R_ENST00000430002.2_Missense_Mutation_p.E574K|PTH1R_ENST00000449590.1_Missense_Mutation_p.E574K|PTH1R_ENST00000418619.1_Missense_Mutation_p.E574K			Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	574						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						CCTGGACGAGGAGGCCTCTGG	0.652000													57	120					0	0	1	0	0
PELP1	27043	broad.mit.edu	37	17	4577868	4577868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4577868G>A	ENST00000301396.4	-	13	2176	c.1951C>T	c.(1951-1953)Ccg>Tcg	p.P651S	PELP1_ENST00000572293.1_Missense_Mutation_p.P557S|PELP1_ENST00000436683.2_Missense_Mutation_p.P360S|PELP1_ENST00000269230.7_Missense_Mutation_p.P505S|PELP1_ENST00000574876.1_Missense_Mutation_p.P507S			Q8IZL8	PELP1_HUMAN	proline, glutamate and leucine rich protein 1	507	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						TGGCTTGGCGGGGCCATAGCT	0.642000													7	26					0	0	1	0	0
C1QC	714	broad.mit.edu	37	1	22974025	22974025	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22974025C>T	ENST00000374639.3	+	3	605	c.487C>T	c.(487-489)Ccc>Tcc	p.P163S	C1QC_ENST00000374637.1_Missense_Mutation_p.P163S|C1QC_ENST00000374640.4_Missense_Mutation_p.P163S	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	163	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTGCAAAGTCCCCGGCCTCTA	0.592000													14	46					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42807045	42807045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:42807045G>A	ENST00000514985.1	-	3	625	c.369C>T	c.(367-369)gtC>gtT	p.V123V	CTD-2325A15.5_ENST00000606056.1_RNA|SEPP1_ENST00000511224.1_Silent_p.V123V|SEPP1_ENST00000506577.1_Silent_p.V123V|SEPP1_ENST00000507920.1_Intron|SEPP1_ENST00000509276.1_Intron	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1	123					response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						AAAGAGTCCAGACATCTGTTT	0.323000													21	54					0	0	1	0	0
CC2D2B	387707	broad.mit.edu	37	10	97779519	97779519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97779519G>A	ENST00000344386.3	+	8	882	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K	ENTPD1-AS1_ENST00000454638.1_RNA|RP11-690P14.4_ENST00000475252.2_Intron|ENTPD1-AS1_ENST00000458228.1_RNA|ENTPD1-AS1_ENST00000452728.1_RNA|CC2D2B_ENST00000410012.2_Missense_Mutation_p.E240K|ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA|CC2D2B_ENST00000371198.2_Intron	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	240										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		CTATTCAAAGGAAAGTTTCTG	0.333000													62	165					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132736524	132736524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132736524C>T	ENST00000265342.7	-	4	564	c.315G>A	c.(313-315)ggG>ggA	p.G105G		NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	105	Kazal-like.					extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATAAAACCTCCCATCAGAGC	0.587000													10	72					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10713855	10713855	+	Silent	SNP	G	G	A	rs147506563		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10713855G>A	ENST00000377022.3	-	11	2576	c.2259C>T	c.(2257-2259)gcC>gcT	p.A753A	RP4-734G22.3_ENST00000606802.1_RNA|CASZ1_ENST00000344008.5_Silent_p.A753A	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	753					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGGCAGTGGCGGCAGCCAGGG	0.672000													9	62					0	0	1	0	0
SERPINF1	5176	broad.mit.edu	37	17	1674335	1674335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:1674335G>A	ENST00000254722.4	+	4	459	c.296G>A	c.(295-297)cGa>cAa	p.R99Q	SERPINF1_ENST00000571870.1_3'UTR	NM_002615.5	NP_002606.3	P36955	PEDF_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	99					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	16						GCGGAGCAGCGAACAGAATCC	0.542000													56	52					0	0	1	0	0
GALNT3	2591	broad.mit.edu	37	2	166611219	166611219	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166611219G>T	ENST00000392701.3	-	9	2319	c.1544C>A	c.(1543-1545)cCt>cAt	p.P515H	GALNT3_ENST00000409882.1_Missense_Mutation_p.P253H	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	515	Ricin B-type lectin.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						CAGACATAGAGGCTGACCAAC	0.313000													7	18					8.12818e-05	8.14046e-05	1	1	0
DGKA	1606	broad.mit.edu	37	12	56345462	56345462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56345462G>A	ENST00000331886.5	+	18	1936	c.1482G>A	c.(1480-1482)gtG>gtA	p.V494V	DGKA_ENST00000394147.1_Silent_p.V494V|DGKA_ENST00000551156.1_Silent_p.V494V|DGKA_ENST00000549079.2_3'UTR	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	494	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	TGAGTAAAGTGGTACATATGG	0.433000													11	112					0	0	1	0	0
HOXD10	3236	broad.mit.edu	37	2	176982108	176982108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:176982108C>T	ENST00000249501.4	+	1	802	c.547C>T	c.(547-549)Cgt>Tgt	p.R183C	HOXD10_ENST00000490088.2_Intron	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	183						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GCTCAACCCTCGTGGCGCGGC	0.582000													27	86					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45387220	45387220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45387220C>T	ENST00000389039.6	-	32	4694	c.4309G>A	c.(4309-4311)Gag>Aag	p.E1437K	DUOX2_ENST00000603300.1_Missense_Mutation_p.E1437K			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1437					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TCGTTCTCCTCCACCTCTTGG	0.567000													23	47					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71907125	71907125	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71907125G>A	ENST00000393679.1	+	5	1114	c.678G>A	c.(676-678)gcG>gcA	p.A226A	FOLR1_ENST00000393676.3_Silent_p.A226A|FOLR1_ENST00000312293.4_Silent_p.A226A|RP11-807H22.7_ENST00000378140.3_RNA|FOLR1_ENST00000393681.2_Silent_p.A226A			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	226					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						AGGAGGTGGCGAGGTTCTATG	0.627000													26	52					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121613	50121613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50121613C>T	ENST00000374160.3	-	1	664	c.588G>A	c.(586-588)gaG>gaA	p.E196E	WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron|RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Silent_p.E196E	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	196						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CATACAAGTTCTCCAGCCTCC	0.493000													35	83					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51215210	51215210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51215210G>A	ENST00000293441.1	-	6	972	c.954C>T	c.(952-954)atC>atT	p.I318I	SHANK1_ENST00000359082.3_Silent_p.I318I|SHANK1_ENST00000391814.1_Silent_p.I318I	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	318					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCACCTGGTGGATTTCCTGCC	0.642000													34	103					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69434189	69434189	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69434189C>T	ENST00000317746.2	-	1	56	c.14G>A	c.(13-15)tGg>tAg	p.W5*		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	5					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						GACTGACATCCATTTCAGAGA	0.408000													86	329					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86355248	86355248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86355248C>T	ENST00000370571.2	-	32	3337	c.2971G>A	c.(2971-2973)Gag>Aag	p.E991K	COL24A1_ENST00000436319.1_Missense_Mutation_p.E991K	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	991	Collagen-like 8.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTTACTGGCTCTCCTGGAAGT	0.378000													33	75					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140174612	140174612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140174612C>T	ENST00000526136.1	+	1	63	c.63C>T	c.(61-63)ctC>ctT	p.L21L	PCDHA2_ENST00000378132.1_Silent_p.L21L|PCDHA2_ENST00000520672.2_Silent_p.L21L|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGCTCCTCGCAGCCTGGG	0.622000													28	74					0	0	1	0	0
EFCAB4A	283229	broad.mit.edu	37	11	828658	828658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:828658G>A	ENST00000450448.1	+	2	556	c.51G>A	c.(49-51)ggG>ggA	p.G17G	AP006621.8_ENST00000532946.1_RNA|EFCAB4A_ENST00000528542.2_Silent_p.G17G|EFCAB4A_ENST00000525077.1_Silent_p.G17G	NM_173584.3	NP_775855.3	Q8N4Y2	EFC4A_HUMAN	EF-hand calcium binding domain 4A	17					store-operated calcium entry		calcium ion binding			endometrium(1)|large_intestine(1)|lung(1)	3		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGGAGGAGGGGGAACTCGAGG	0.642000													16	54					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110670406	110670406	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110670406G>A	ENST00000394634.2	-	10	1323	c.1116C>T	c.(1114-1116)ggC>ggT	p.G372G	CFI_ENST00000512148.1_Silent_p.G365G|CFI_ENST00000394635.3_Silent_p.G380G	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	372	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		GAATCCAACAGCCACCAATAT	0.438000													104	264					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223154	44223154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44223154C>T	ENST00000244314.5	+	2	643	c.444C>T	c.(442-444)gtC>gtT	p.V148V		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	148						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				GCGGGGCCGTCGAGACCCGCC	0.662000													4	17					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54844923	54844923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54844923G>A	ENST00000291759.4	-	8	1476	c.1420C>T	c.(1420-1422)Ccc>Tcc	p.P474S	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	474						integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CACCTTGGGGGGCTTCTCTGG	0.547000													18	71					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88027630	88027630	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88027630T>C	ENST00000227266.5	-	7	1050	c.936A>G	c.(934-936)caA>caG	p.Q312Q		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	312			Q -> R (in PLS).		immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCCCAAAATCTTGGGCGTACT	0.458000													22	60					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233134126	233134126	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233134126C>A	ENST00000258229.8	-	32	5896	c.5662G>T	c.(5662-5664)Gga>Tga	p.G1888*	PCNXL2_ENST00000344698.2_Nonsense_Mutation_p.G540*	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1888						integral to membrane		p.G1888R(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GCCCCTCCTCCGTCCACGTCT	0.617000													8	47					7.48243e-07	7.50068e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179474571	179474571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179474571C>T	ENST00000589042.1	-	272	51803	c.51579G>A	c.(51577-51579)agG>agA	p.R17193R	TTN_ENST00000342992.6_Silent_p.R14625R|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.R15552R|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Silent_p.R8320R|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.R8253R|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.R8128R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15552	Fibronectin type-III 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCTTCCACCTTTCTTCAC	0.468000													157	416					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897633	175897633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175897633G>A	ENST00000359240.3	+	5	1627	c.957G>A	c.(955-957)atG>atA	p.M319I	ADAM29_ENST00000445694.1_Missense_Mutation_p.M319I|ADAM29_ENST00000404450.4_Missense_Mutation_p.M319I|ADAM29_ENST00000514159.1_Missense_Mutation_p.M319I	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	319	Peptidase M12B.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTACTTTCATGAACAAAACTT	0.403000													67	178					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23396742	23396742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23396742G>A	ENST00000324366.8	-	4	666	c.443C>T	c.(442-444)tCt>tTt	p.S148F	PRMT5_ENST00000397440.4_Intron|PRMT5_ENST00000553641.1_5'UTR|PRMT5_ENST00000553897.1_Missense_Mutation_p.S104F|PRMT5_ENST00000538452.1_Missense_Mutation_p.S42F|PRMT5_ENST00000216350.8_Missense_Mutation_p.S87F|PRMT5_ENST00000397441.2_Missense_Mutation_p.S131F	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	148					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TACCATGGAAGAGTGATGGCC	0.488000													23	55					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125621339	125621339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125621339C>T	ENST00000316519.6	+	17	2016	c.1810C>T	c.(1810-1812)Cgt>Tgt	p.R604C	AACS_ENST00000261686.6_Intron|AACS_ENST00000545511.1_Intron|AACS_ENST00000543665.1_Intron|AACS_ENST00000316543.10_Missense_Mutation_p.R202C	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	604					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		TAAGAGGATCCGTGACGCCAT	0.607000													16	72					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811108	140811108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:140811108C>T	ENST00000509479.2	-	2	2338	c.1482G>A	c.(1480-1482)caG>caA	p.Q494Q	MAML3_ENST00000398940.1_Silent_p.Q33Q|MAML3_ENST00000327122.5_Silent_p.Q338Q	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	494	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.537000													4	38					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455121	84455121	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:84455121G>A	ENST00000377084.2	-	1	1407	c.522C>T	c.(520-522)ttC>ttT	p.F174F		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	174						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCACATACTGGAACACGTTGG	0.527000													25	79					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380453	56380453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56380453G>A	ENST00000526538.1	-	1	525	c.526C>T	c.(526-528)Cat>Tat	p.H176Y		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						CAGTAGAAATGATTGATTTCA	0.453000													13	50					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47944643	47944643	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47944643A>T	ENST00000236877.6	-	5	2213	c.1818T>A	c.(1816-1818)aaT>aaA	p.N606K	SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000539381.1_Missense_Mutation_p.N69K|SLC8A2_ENST00000542837.1_Missense_Mutation_p.N362K	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	606	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CAATGAAGAAATTATCCTTTT	0.542000													23	44					0	0	1	0	0
FASLG	356	broad.mit.edu	37	1	172634851	172634851	+	Missense_Mutation	SNP	C	C	T	rs80358236		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:172634851C>T	ENST00000367721.2	+	4	725	c.541C>T	c.(541-543)Ctt>Ttt	p.L181F	FASLG_ENST00000340030.3_3'UTR	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	181					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						GAAGGGTGGCCTTGTGATCAA	0.458000													14	95					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122437790	122437790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122437790C>T	ENST00000474629.2	+	14	5058	c.4792C>T	c.(4792-4794)Ctc>Ttc	p.L1598F	PARP14_ENST00000475640.1_3'UTR	NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1598	WWE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		TGTTCAGCGCCTCACGAAATC	0.388000													5	24					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103898452	103898452	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103898452C>T	ENST00000278070.2	+	3	458	c.419C>T	c.(418-420)tCt>tTt	p.S140F	PPRC1_ENST00000413464.2_Missense_Mutation_p.S140F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AATGCAGATTCTGAGAACCTT	0.532000													25	54					0	0	1	0	0
FANK1	92565	broad.mit.edu	37	10	127668815	127668815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:127668815G>A	ENST00000368695.1	+	2	203	c.81G>A	c.(79-81)aaG>aaA	p.K27K	FANK1_ENST00000368693.1_Silent_p.K33K|FANK1_ENST00000449042.2_Silent_p.K27K|FANK1_ENST00000368689.1_Silent_p.K27K	NM_145235.3	NP_660278.3	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains 1	33	Fibronectin type-III.					cytoplasm|nucleus				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(10)|ovary(1)|urinary_tract(1)	21		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				ATCTGGAAAAGAAAGCCAAAC	0.438000													32	44					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65239996	65239996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65239996G>A	ENST00000389722.3	-	24	5173	c.5120C>T	c.(5119-5121)tCa>tTa	p.S1707L	SPTB_ENST00000556626.1_Missense_Mutation_p.S1707L|SPTB_ENST00000542895.1_Missense_Mutation_p.S1707L|SPTB_ENST00000389721.5_Missense_Mutation_p.S1707L|SPTB_ENST00000389720.3_Missense_Mutation_p.S1707L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1707					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTCCTTTTCTGAAATCCACTG	0.547000													24	62					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106207896	106207896	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106207896C>T	ENST00000390548.2	-	0	906																											AAGACGTTCCCCTGCTGCCAC	0.597000													36	118					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111540184	111540184	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:111540184C>T	ENST00000261486.5	-	15	1540	c.1262_splice	c.e15-1	p.G422_splice	CTC-459M5.2_ENST00000505825.1_RNA|CTC-459M5.2_ENST00000506875.1_RNA|EPB41L4A_ENST00000507810.1_5'UTR	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	422						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TTGTAGAGTCCACTGGAGAGA	0.507000													35	72					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849514	73849514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73849514G>A	ENST00000523207.1	+	3	2512	c.1924G>A	c.(1924-1926)Gag>Aag	p.E642K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	642					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AGGGACAGAAGAGCACCAAAG	0.592000													37	101					0	0	1	0	0
SOX13	9580	broad.mit.edu	37	1	204086786	204086786	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204086786C>T	ENST00000367204.1	+	7	835	c.726C>T	c.(724-726)acC>acT	p.T242T	SOX13_ENST00000367203.4_3'UTR	NM_005686.2	NP_005677.2	Q9UN79	SOX13_HUMAN	SRY (sex determining region Y)-box 13	242	Pro-rich.				anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	13	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			TGCCTGTCACCCCTGACTCCC	0.587000													10	20					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21402245	21402245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21402245G>A	ENST00000313654.9	+	20	2575	c.2334G>A	c.(2332-2334)ggG>ggA	p.G778G	LAMA3_ENST00000399516.3_Silent_p.G778G	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	778					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAATGTAGGGAAGTCAAGTG	0.383000													32	74					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171168627	171168627	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171168627G>A	ENST00000441535.1	+	5	744	c.627_splice	c.e5+1	p.Q209_splice	RP1-127D3.4_ENST00000422841.1_RNA|FMO2_ENST00000529935.1_Intron|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000209929.7_Splice_Site_p.Q209_splice|RP1-127D3.4_ENST00000445290.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	209					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGCTGCTCAGGTGTGATGCT	0.498000													16	97					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60887760	60887760	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60887760T>C	ENST00000252999.3	-	67	9221	c.9155A>G	c.(9154-9156)gAg>gGg	p.E3052G		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3052	Laminin G-like 2.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATTGTCCTGCTCCACGCTGTA	0.687000													3	12					0	0	1	0	0
AADACL2	344752	broad.mit.edu	37	3	151451837	151451837	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151451837C>T	ENST00000356517.3	+	1	123	c.14C>T	c.(13-15)gCt>gTt	p.A5V		NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	5						extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GGGCTAAAAGCTCTCTGTTTG	0.388000													11	18					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67430797	67430797	+	Silent	SNP	G	G	A	rs111978289		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67430797G>A	ENST00000349015.3	-	10	1485	c.1047C>T	c.(1045-1047)ctC>ctT	p.L349L	ALDH3B2_ENST00000530069.1_Silent_p.L349L	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	349					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	CGGAGGGGGCGAGCAGGCAGG	0.617000													13	42					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142037485	142037485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142037485G>A	ENST00000264951.4	-	39	4684	c.4567C>T	c.(4567-4569)Cct>Tct	p.P1523S	XRN1_ENST00000392981.2_Missense_Mutation_p.P1524S	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1523					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						ACAGCTGAAGGATAATTTGCA	0.368000													5	11					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25490468	25490468	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25490468C>T	ENST00000453082.2	+	0	2619					NR_003343.1																						TGTATTGGGCCCCCACAGGCC	0.617000													6	23					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033554	95033554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95033554G>A	ENST00000557004.1	+	3	1318	c.897G>A	c.(895-897)atG>atA	p.M299I	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Missense_Mutation_p.M299I|SERPINA4_ENST00000298841.5_Missense_Mutation_p.M299I			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	299					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		AGATGCTAATGAGGTGGAACA	0.438000													18	53					0	0	1	0	0
GADL1	339896	broad.mit.edu	37	3	30885930	30885930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:30885930G>A	ENST00000454381.3	-	7	726	c.680C>T	c.(679-681)tCt>tTt	p.S227F	GADL1_ENST00000282538.5_Missense_Mutation_p.S227F			Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	227					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding			breast(2)|endometrium(3)|kidney(2)|lung(17)|upper_aerodigestive_tract(1)	25					Pyridoxal Phosphate(DB00114)	CCCAAGAAAAGAGGCTGCCTT	0.433000													52	152					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91389464	91389464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:91389464G>A	ENST00000509176.1	+	5	1971	c.1683G>A	c.(1681-1683)atG>atA	p.M561I	CCSER1_ENST00000432775.2_Missense_Mutation_p.M561I|CCSER1_ENST00000333691.8_Missense_Mutation_p.M561I	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		TGATAGAAATGAAGAAAAGAG	0.383000													12	33					0	0	1	0	0
RBM39	9584	broad.mit.edu	37	20	34312576	34312576	+	Silent	SNP	G	G	A	rs151187023		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34312576G>A	ENST00000361162.6	-	8	987	c.603C>T	c.(601-603)ttC>ttT	p.F201F	RBM39_ENST00000253363.6_Silent_p.F201F|RBM39_ENST00000528062.3_Silent_p.F179F|RBM39_ENST00000407261.4_Silent_p.F44F	NM_004902.3|NM_184234.2	NP_004893.1|NP_909122.1	Q14498	RBM39_HUMAN	RNA binding motif protein 39	201	RRM 1.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TAACATCGACGAACTCCACAT	0.413000													42	83					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39068745	39068745	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39068745C>T	ENST00000379907.4	+	12	1262	c.1135C>T	c.(1135-1137)Ctt>Ttt	p.L379F	ADAM32_ENST00000437682.2_Intron|ADAM32_ENST00000519315.1_Intron	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	379	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGTCAAATGTCTTCAGAATAA	0.393000													11	15					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57256424	57256424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57256424G>A	ENST00000278426.3	-	13	1729	c.1374C>T	c.(1372-1374)ttC>ttT	p.F458F	SLC43A1_ENST00000528450.1_Silent_p.F458F	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	458					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						CTGAGTGGAAGAAACCTCGAA	0.512000													13	65					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836687	142836687	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142836687C>T	ENST00000291009.3	+	4	433	c.393C>T	c.(391-393)ccC>ccT	p.P131P		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	131						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		CTGTAATCCCCATCAAAAACA	0.438000													66	187					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228474494	228474494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228474494C>T	ENST00000570156.2	+	40	10659	c.10585C>T	c.(10585-10587)Cgg>Tgg	p.R3529W	OBSCN_ENST00000366707.4_Missense_Mutation_p.R219W|OBSCN_ENST00000422127.1_Missense_Mutation_p.R3100W|OBSCN_ENST00000284548.11_Missense_Mutation_p.R3100W|OBSCN_ENST00000366709.4_Missense_Mutation_p.R219W|OBSCN_ENST00000359599.6_Missense_Mutation_p.R1947W	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2562	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGTCTTCTCCCGGGAGCTCAC	0.612000													20	42					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20329572	20329572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20329572C>T	ENST00000302555.5	-	7	1337	c.1188G>A	c.(1186-1188)agG>agA	p.R396R	GP2_ENST00000341642.5_Silent_p.R249R|GP2_ENST00000381360.5_Silent_p.R252R|GP2_ENST00000381362.4_Silent_p.R399R			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	399	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CATAGCAGTTCCTCAACACCA	0.483000													15	82					0	0	1	0	0
CIZ1	25792	broad.mit.edu	37	9	130952661	130952661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130952661G>A	ENST00000538431.1	-	3	480	c.233C>T	c.(232-234)tCc>tTc	p.S78F	CIZ1_ENST00000372938.5_Missense_Mutation_p.S78F|CIZ1_ENST00000372954.1_Missense_Mutation_p.S78F|CIZ1_ENST00000372948.3_Missense_Mutation_p.S78F|CIZ1_ENST00000357558.5_Missense_Mutation_p.S78F|CIZ1_ENST00000277465.4_Missense_Mutation_p.S78F|CIZ1_ENST00000393608.1_Missense_Mutation_p.S78F|CIZ1_ENST00000541172.1_Intron|CIZ1_ENST00000476727.2_Intron|CIZ1_ENST00000325721.8_Missense_Mutation_p.S78F	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	78						nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						GTTGAGGAGGGAGGCTGAGTT	0.577000													8	20					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73472451	73472451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73472451G>A	ENST00000224721.6	+	27	3270	c.3265G>A	c.(3265-3267)Ggc>Agc	p.G1089S	C10orf105_ENST00000398786.2_3'UTR|C10orf105_ENST00000441508.2_3'UTR	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1084	Cadherin 10.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCGACACACGGGCACAGCCAC	0.577000													7	25					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1515939	1515939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:1515939G>A	ENST00000389470.4	-	39	5915	c.5916C>T	c.(5914-5916)tgC>tgT	p.C1972C	INTS1_ENST00000404767.3_Silent_p.C1768C			Q8N201	INT1_HUMAN	integrator complex subunit 1	1768					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CCCCACAGCAGCAGCTGAGCA	0.687000													4	11					0	0	1	0	0
IGLV3-12	28802	broad.mit.edu	37	22	23114868	23114868	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23114868G>A	ENST00000390313.2	+	0	149																											AACAACATTGGAAGTAAAGCT	0.562000													9	41					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45410347	45410347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45410347C>T	ENST00000332700.6	-	4	913	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	248						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E248K(1)		endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GAAAGCACTTCCTTTTCTTTG	0.418000													54	124					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57261486	57261486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57261486G>A	ENST00000278426.3	-	8	1206	c.851C>T	c.(850-852)aCc>aTc	p.T284I	SLC43A1_ENST00000528450.1_Missense_Mutation_p.T284I|SLC43A1_ENST00000533515.1_5'UTR	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	284					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						GTTTTCTGAGGTGCCCCGAAC	0.577000											OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	34					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93029461	93029461	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:93029461C>T	ENST00000523629.1	-	3	673	c.219G>A	c.(217-219)ccG>ccA	p.P73P	RUNX1T1_ENST00000521553.1_Silent_p.P36P|RUNX1T1_ENST00000520724.1_Silent_p.P36P|RUNX1T1_ENST00000422361.2_Silent_p.P36P|RUNX1T1_ENST00000436581.2_Silent_p.P84P|RUNX1T1_ENST00000518844.1_Silent_p.P46P|RUNX1T1_ENST00000360348.2_Silent_p.P36P|RUNX1T1_ENST00000265814.3_Silent_p.P73P|RUNX1T1_ENST00000396218.1_Silent_p.P46P	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	73					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TACACGTTGTCGGTGTAAATG	0.388000													17	84					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784985	9784985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9784985C>T	ENST00000304374.2	+	1	1728	c.1332C>T	c.(1330-1332)tcC>tcT	p.S444S		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	444					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ATCAGACGTCCCCAGATGGTG	0.547000													30	54					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976513	38976513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38976513G>A	ENST00000355481.4	+	34	5349	c.5218G>A	c.(5218-5220)Gag>Aag	p.E1740K	RYR1_ENST00000359596.3_Missense_Mutation_p.E1740K|RYR1_ENST00000360985.3_Missense_Mutation_p.E1740K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1740	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCTCACGCCTGAGACCCGCGC	0.632000													28	93					0	0	1	0	0
NXPE1	120400	broad.mit.edu	37	11	114393141	114393141	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:114393141C>T	ENST00000536271.1	-	4	1584	c.341G>A	c.(340-342)tGg>tAg	p.W114*	NXPE1_ENST00000251921.2_Nonsense_Mutation_p.W256*|NXPE1_ENST00000424269.1_Nonsense_Mutation_p.W398*					neurexophilin and PC-esterase domain family, member 1																		ATGTTTTTTCCATTGAATCTG	0.373000													37	83					0	0	1	0	0
CLEC3B	7123	broad.mit.edu	37	3	45077054	45077054	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45077054C>T	ENST00000296130.4	+	3	427	c.247C>T	c.(247-249)Ctg>Ttg	p.L83L	CLEC3B_ENST00000428034.1_Silent_p.L41L|CLEC3B_ENST00000490386.1_3'UTR	NM_003278.2	NP_003269.2	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	83	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding			endometrium(1)|lung(3)	4				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAATGCTTTCTGGCCTTCAC	0.627000													25	36					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370539	35370539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35370539C>T	ENST00000373347.1	-	3	714	c.446G>A	c.(445-447)gGg>gAg	p.G149E	DLGAP3_ENST00000235180.4_Missense_Mutation_p.G149E			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	149					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				TGGCCCGGGCCCTGCCCCTGC	0.627000													12	25					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21896403	21896403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21896403G>A	ENST00000399982.2	-	3	1290	c.1226C>T	c.(1225-1227)tCc>tTc	p.S409F	CHD8_ENST00000557364.1_Missense_Mutation_p.S409F|CHD8_ENST00000430710.3_Missense_Mutation_p.S130F|CHD8_ENST00000555962.1_Intron	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	409	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GGCCCCTTGGGAAGAGCCAGC	0.473000													11	95					0	0	1	0	0
HMGCS1	3157	broad.mit.edu	37	5	43298724	43298724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:43298724G>A	ENST00000325110.6	-	3	550	c.344C>T	c.(343-345)tCt>tTt	p.S115F	HMGCS1_ENST00000433297.2_Missense_Mutation_p.S115F	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	115					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						TGTATTCCCAGACTCTTCAAA	0.438000													42	104					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47247088	47247088	+	Nonstop_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47247088T>C	ENST00000300404.2	+	11	1758	c.1699T>C	c.(1699-1701)Taa>Caa	p.*567Q	B4GALNT2_ENST00000393354.2_Nonstop_Mutation_p.*507Q|B4GALNT2_ENST00000504681.1_Nonstop_Mutation_p.*481Q	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	0					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			ATGTGCCGCATAAAGGTGTGA	0.502000													13	25					0	0	1	0	0
TNFSF8	944	broad.mit.edu	37	9	117666367	117666367	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117666367C>T	ENST00000223795.2	-	4	662	c.549G>A	c.(547-549)acG>acA	p.T183T	TNFSF8_ENST00000474301.1_Intron	NM_001244.3	NP_001235.1	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily, member 8	183					cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding	p.T183T(2)		endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(3)|urinary_tract(1)	12						ATACGTGTTTCGTTTGCATTC	0.418000													57	107					0	0	1	0	0
GZMK	3003	broad.mit.edu	37	5	54326282	54326282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54326282C>T	ENST00000231009.2	+	3	303	c.233C>T	c.(232-234)cCc>cTc	p.P78L	CTD-2313F11.1_ENST00000596137.1_RNA|CTD-2313F11.1_ENST00000595218.1_RNA	NM_002104.2	NP_002095.1	P49863	GRAK_HUMAN	granzyme K (granzyme 3; tryptase II)	78	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)	15		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GGCCAGTCTCCCACTGTGGTT	0.438000													36	110					0	0	1	0	0
S100P	6286	broad.mit.edu	37	4	6695749	6695749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6695749G>A	ENST00000296370.3	+	1	954	c.90G>A	c.(88-90)aaG>aaA	p.K30K	S100P_ENST00000513778.1_Intron	NM_005980.2	NP_005971.1	P25815	S100P_HUMAN	S100 calcium binding protein P	30	EF-hand 1.				endothelial cell migration	cytoplasm|nucleus	calcium ion binding|calcium-dependent protein binding|magnesium ion binding			prostate(1)	1		Myeloproliferative disorder(84;0.0255)		Colorectal(103;0.011)	Cromoglicate(DB01003)	CCCTGACCAAGGGGGAGCTCA	0.597000													20	40					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228479753	228479753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228479753G>A	ENST00000570156.2	+	44	11855	c.11781G>A	c.(11779-11781)caG>caA	p.Q3927Q	OBSCN_ENST00000366707.4_Silent_p.Q617Q|OBSCN_ENST00000422127.1_Silent_p.Q3498Q|OBSCN_ENST00000284548.11_Silent_p.Q3498Q|OBSCN_ENST00000366709.4_Silent_p.Q617Q|OBSCN_ENST00000359599.6_Silent_p.Q2345Q	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2965	Ig-like 40.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCTGAGGCAGGAGGGGACCA	0.627000													29	65					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22202047	22202047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:22202047G>A	ENST00000344041.6	-	13	1249	c.937C>T	c.(937-939)Cct>Tct	p.P313S	RAPGEF5_ENST00000401957.2_Missense_Mutation_p.P163S	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	163					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						TCATCTTCAGGTAACCAGTCT	0.348000													20	59					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68021426	68021426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68021426G>A	ENST00000412757.2	-	12	2109	c.1444C>T	c.(1444-1446)Ctt>Ttt	p.L482F	DPEP2_ENST00000393847.1_Missense_Mutation_p.L482F|DPEP2_ENST00000572888.1_Missense_Mutation_p.L482F			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	482					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		CACAGAATAAGGACTGGGAAG	0.542000													20	174					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325305	158325305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158325305C>T	ENST00000444681.2	+	2	567	c.274C>T	c.(274-276)Cct>Tct	p.P92S	CD1E_ENST00000368157.1_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368165.3_Intron|CD1E_ENST00000368163.3_Missense_Mutation_p.P191S|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.P189S|CD1E_ENST00000368167.3_Missense_Mutation_p.P191S|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000368161.3_Missense_Mutation_p.P191S|CD1E_ENST00000368160.3_Missense_Mutation_p.P191S|CD1E_ENST00000368166.3_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	191					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					TCACACCTGCCCTCGATTTCT	0.502000													4	45					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6897452	6897452	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6897452C>T	ENST00000312053.4	+	5	445	c.408C>T	c.(406-408)tgC>tgT	p.C136C	EMR1_ENST00000381407.5_Intron|EMR1_ENST00000601198.1_3'UTR|EMR1_ENST00000381404.4_Silent_p.C84C|EMR1_ENST00000250572.8_Silent_p.C136C|EMR1_ENST00000450315.3_Silent_p.C136C	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	136	EGF-like 3; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TCAATGAGTGCCTCACCAGCA	0.478000													25	46					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31743748	31743748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31743748G>A	ENST00000375686.3	-	3	743	c.506C>T	c.(505-507)gCc>gTc	p.A169V	VWA7_ENST00000447450.1_Missense_Mutation_p.A169V|VWA7_ENST00000467576.1_Intron|VWA7_ENST00000375688.4_Missense_Mutation_p.A169V	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	169						extracellular region											CACCTGCAGGGCATGAAGTGC	0.657000													75	145					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32526727	32526727	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32526727G>A	ENST00000286827.3	-	18	3480	c.3009C>T	c.(3007-3009)gcC>gcT	p.A1003A	TIAM1_ENST00000541036.1_Silent_p.A943A	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1003					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GGCAAAATGCGGCCACCTGTT	0.582000													27	69					0	0	1	0	0
EPHX4	253152	broad.mit.edu	37	1	92511195	92511195	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92511195C>T	ENST00000370383.4	+	4	680	c.582C>T	c.(580-582)ttC>ttT	p.F194F		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	194						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						TTATTAACTTCCCTCATCCAA	0.388000													35	99					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236755334	236755334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236755334G>A	ENST00000366582.3	-	11	1495	c.1381C>T	c.(1381-1383)Cat>Tat	p.H461Y	HEATR1_ENST00000366581.2_Missense_Mutation_p.H461Y	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	461					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACAAACTGATGGAAAAGCTCT	0.353000													27	104					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55220936	55220936	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55220936G>A	ENST00000413439.1	+	0	925																											TTTGATTGAGGAAGGAGAAAA	0.572000													7	21					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48335705	48335705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:48335705C>T	ENST00000428869.2	-	4	324	c.66G>A	c.(64-66)caG>caA	p.Q22Q	MRO_ENST00000436348.2_Intron|MRO_ENST00000587291.1_Intron|MRO_ENST00000256425.2_Silent_p.Q22Q|MRO_ENST00000398439.3_Silent_p.Q22Q|MRO_ENST00000588444.1_Silent_p.Q22Q|MRO_ENST00000431965.2_Intron			Q9BYG7	MSTRO_HUMAN	maestro	22						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		ATGTCCTTTTCTGCTTGGGCT	0.413000													33	77					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121356038	121356038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121356038C>T	ENST00000314583.3	-	7	611	c.520G>A	c.(520-522)Gga>Aga	p.G174R	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Intron	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	174					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		TAGTCATATCCCAGAGCTGCT	0.547000													7	121					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230224	56230224	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56230224G>A	ENST00000279791.1	-	1	653	c.654C>T	c.(652-654)ctC>ctT	p.L218L		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					CTACTACAATGAGAGTGTAGG	0.488000													6	24					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56823451	56823451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:56823451C>T	ENST00000257287.4	+	5	659	c.535C>T	c.(535-537)Ccc>Tcc	p.P179S	CEP135_ENST00000422247.2_Missense_Mutation_p.P179S	NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	179					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					ACCGGTTCCTCCCTCTGAAGT	0.408000													32	151					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231222521	231222521	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231222521C>T	ENST00000243810.6	+	3	109	c.107_splice	c.e3-1	p.L37_splice	SP140_ENST00000486687.2_Splice_Site_p.A760_splice|SP140L_ENST00000415673.2_Splice_Site_p.L37_splice|SP140L_ENST00000444636.1_Splice_Site_p.L37_splice|SP140L_ENST00000396563.4_Splice_Site_p.L37_splice|SP140L_ENST00000458341.1_5'UTR			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	37	HSR.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						TTTCCTTAGGCTGTTCACGGA	0.373000													53	182					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204490	9204490	+	Silent	SNP	G	G	A	rs139852545	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9204490G>A	ENST00000429566.3	+	1	636	c.570G>A	c.(568-570)acG>acA	p.T190T		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TTTCGTGCACGGACACCTCTG	0.562000													48	108					0	0	1	0	0
OR8B3	390271	broad.mit.edu	37	11	124267101	124267101	+	Silent	SNP	G	G	A	rs140121900	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124267101G>A	ENST00000354597.3	-	1	163	c.147C>T	c.(145-147)ttC>ttT	p.F49F		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AATTTAGACCGAAAAGAATGA	0.418000													69	92					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90504325	90504325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:90504325G>A	ENST00000369393.3	-	3	640	c.525C>T	c.(523-525)ctC>ctT	p.L175L	MDN1_ENST00000428876.1_Silent_p.L175L			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	175					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGCTTCTGAGGAGAGGGACAC	0.542000													17	41					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55142285	55142285	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55142285G>A	ENST00000370862.3	+	5	1206	c.870G>A	c.(868-870)gcG>gcA	p.A290A		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	290					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCGCTGTGGCGGCTGAAATAA	0.498000													16	51					0	0	1	0	0
ENTPD8	377841	broad.mit.edu	37	9	140331432	140331432	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140331432C>T	ENST00000371506.2	-	5	627	c.444G>A	c.(442-444)caG>caA	p.Q148Q	ENTPD8_ENST00000344119.2_Silent_p.Q148Q|ENTPD8_ENST00000472938.1_Silent_p.Q148Q	NM_001033113.1	NP_001028285.1	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	148						integral to membrane|plasma membrane	ATP binding			biliary_tract(1)|lung(4)|prostate(1)|skin(1)	7	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GGCCCAGGACCTGGGTGACTG	0.662000													12	71					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49067928	49067928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:49067928C>T	ENST00000376265.2	-	36	4208	c.4147G>A	c.(4147-4149)Gag>Aag	p.E1383K	CACNA1F_ENST00000323022.5_Missense_Mutation_p.E1372K|CACNA1F_ENST00000376251.1_Missense_Mutation_p.E1318K	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1383		Calcium ion selectivity and permeability (By similarity).			axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	TGCCATGCCTCACCAGTGGCA	0.547000													16	17					0	0	1	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98728846	98728846	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:98728846A>G	ENST00000288985.7	+	14	2288	c.1983A>G	c.(1981-1983)caA>caG	p.Q661Q	ERCC6L2_ENST00000466840.1_3'UTR|ERCC6L2_ENST00000437817.1_Silent_p.Q472Q	NM_001010895.2	NP_001010895.1	Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	661	Helicase C-terminal.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										TGTTTTAGCAACTTCACTGTG	0.393000													19	62					0	0	1	0	0
AGAP7	653268	broad.mit.edu	37	10	51465313	51465313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:51465313C>T	ENST00000374095.5	-	7	1268	c.1143G>A	c.(1141-1143)aaG>aaA	p.K381K		NM_001077685.1	NP_001071153.1	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	381	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	11						TGCTTTTCTTCTTTAGGTGTT	0.517000													30	111					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73821098	73821098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73821098G>A	ENST00000342056.2	+	7	1495	c.1097G>A	c.(1096-1098)aGa>aAa	p.R366K	KCNQ5_ENST00000355635.3_Missense_Mutation_p.R366K|KCNQ5_ENST00000355194.4_Missense_Mutation_p.R366K|KCNQ5_ENST00000370398.1_Missense_Mutation_p.R366K|KCNQ5_ENST00000414165.2_Missense_Mutation_p.R366K|KCNQ5_ENST00000403813.2_Missense_Mutation_p.R366K|KCNQ5_ENST00000370392.1_Missense_Mutation_p.R366K|KCNQ5_ENST00000402622.2_Missense_Mutation_p.R366K	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	366					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TTTGAGAAAAGAAGGAACCCA	0.398000													51	86					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049948	9049948	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9049948G>A	ENST00000397910.4	-	5	31886	c.31683C>T	c.(31681-31683)ttC>ttT	p.F10561F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10563	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATTCTCTATTGAAAACAGATG	0.483000													50	116					0	0	1	0	0
NIPSNAP1	8508	broad.mit.edu	37	22	29957530	29957530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29957530G>A	ENST00000216121.7	-	6	798	c.544C>T	c.(544-546)Ccc>Tcc	p.P182S		NM_001202502.1|NM_003634.3	NP_001189431.1|NP_003625.2	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1 (C. elegans)	182								p.?(1)		large_intestine(2)|lung(2)|skin(1)	5						TAGATGTTGGGACCCATTCTG	0.582000													33	78					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50213610	50213610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50213610G>A	ENST00000392518.4	+	15	1972	c.1600G>A	c.(1600-1602)Gcc>Acc	p.A534T	CPT1C_ENST00000405931.2_Missense_Mutation_p.A523T|CPT1C_ENST00000323446.5_Missense_Mutation_p.A534T|CPT1C_ENST00000354199.5_Missense_Mutation_p.A534T|CPT1C_ENST00000598293.1_Missense_Mutation_p.A534T	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	534					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CCTGAGGGGAGCCAAGATCTT	0.527000													10	115					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286021	48286021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48286021C>T	ENST00000320048.1	+	1	609	c.609C>T	c.(607-609)tcC>tcT	p.S203S		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						ATGGCGGCTCCATCTCCGTAG	0.547000													19	32					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179739455	179739455	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179739455G>A	ENST00000253778.8	-	15	1690	c.1521C>T	c.(1519-1521)atC>atT	p.I507I		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	507					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	AGCCACGGATGATCTCTTGCC	0.433000													30	76					0	0	1	0	0
PTRF	284119	broad.mit.edu	37	17	40557273	40557273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40557273G>A	ENST00000357037.5	-	2	1024	c.605C>T	c.(604-606)tCg>tTg	p.S202L		NM_012232.5	NP_036364.2	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	202					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CTCGTCCGACGAAAGCTCCAG	0.667000													83	109					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209791391	209791391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209791391C>T	ENST00000391911.1	-	19	3301	c.2912G>A	c.(2911-2913)aGc>aAc	p.S971N	LAMB3_ENST00000356082.4_Missense_Mutation_p.S971N|LAMB3_ENST00000367030.3_Missense_Mutation_p.S971N	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	971	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		ATGGGCTCGGCTCCTGGGTGA	0.572000													7	77					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37029580	37029580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37029580G>A	ENST00000358047.3	+	1	3149	c.3097G>A	c.(3097-3099)Gaa>Aaa	p.E1033K		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	1033										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGATGCATCGGAAGAAGATTA	0.393000													19	74					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41615665	41615665	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41615665G>A	ENST00000313860.7	+	7	723	c.669G>A	c.(667-669)agG>agA	p.R223R	LIMCH1_ENST00000513024.1_Silent_p.R64R|LIMCH1_ENST00000396595.3_Silent_p.R69R|LIMCH1_ENST00000381753.4_Silent_p.R69R|LIMCH1_ENST00000512946.1_Silent_p.R223R|LIMCH1_ENST00000514096.1_Silent_p.R76R|LIMCH1_ENST00000509454.1_Silent_p.R71R|LIMCH1_ENST00000509277.1_Silent_p.R69R|LIMCH1_ENST00000512820.1_Silent_p.R223R|LIMCH1_ENST00000508501.1_Silent_p.R223R|LIMCH1_ENST00000509638.1_Silent_p.R64R|LIMCH1_ENST00000503057.1_Silent_p.R64R|LIMCH1_ENST00000512632.1_Silent_p.R223R|LIMCH1_ENST00000511496.1_Silent_p.R64R	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	223					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TAGTCCTCAGGGGAAGCAGCG	0.547000													9	66					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768559	140768559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140768559C>T	ENST00000519479.1	+	1	1108	c.1108C>T	c.(1108-1110)Cgt>Tgt	p.R370C	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCAAAGTCCGTGACAAGGA	0.398000													20	77					0	0	1	0	0
BPIFA2	140683	broad.mit.edu	37	20	31761975	31761975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31761975G>A	ENST00000253362.2	+	4	539	c.393G>A	c.(391-393)gcG>gcA	p.A131A	BPIFA2_ENST00000354932.5_Silent_p.A131A			Q96DR5	SPLC2_HUMAN	BPI fold containing family A, member 2	131						extracellular region	lipid binding										CTGTCACCGCGAATGTCACTG	0.532000													28	81					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108455370	108455370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108455370G>A	ENST00000408999.3	+	4	432	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K	RGPD4_ENST00000354986.4_Missense_Mutation_p.E119K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	119					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						ATACTGGGTGGAAAGAGCAGC	0.343000													110	237					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21744103	21744103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21744103G>A	ENST00000328843.6	+	39	6377	c.6346G>A	c.(6346-6348)Gac>Aac	p.D2116N	DNAH11_ENST00000409508.3_Missense_Mutation_p.D2109N			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2116					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGTGACTGACGACATCCCAGT	0.453000									Kartagener syndrome				11	19					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113547155	113547155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113547155C>T	ENST00000416899.2	+	10	1547	c.1421C>T	c.(1420-1422)tCc>tTc	p.S474F	MUSK_ENST00000374448.4_Missense_Mutation_p.S482F|MUSK_ENST00000189978.5_Missense_Mutation_p.S482F|MUSK_ENST00000374438.1_Intron			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	482					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						CCTTCCTCCTCCTCTTCTTCC	0.403000													40	67					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113442792	113442792	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113442792C>T	ENST00000392583.2	+	7	1440	c.1233C>T	c.(1231-1233)ctC>ctT	p.L411L	OAS2_ENST00000342315.4_Silent_p.L411L|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	411	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding	p.L411L(1)		NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						ATGCCGATCTCGTCGTGTTCC	0.478000													19	52					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231314955	231314955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231314955C>T	ENST00000264052.5	+	8	1160	c.805C>T	c.(805-807)Ccc>Tcc	p.P269S	SP100_ENST00000340126.4_Missense_Mutation_p.P269S|SP100_ENST00000427101.2_Missense_Mutation_p.P244S|SP100_ENST00000409341.1_Missense_Mutation_p.P269S|SP100_ENST00000409824.1_Missense_Mutation_p.P244S|SP100_ENST00000409112.1_Missense_Mutation_p.P269S|SP100_ENST00000341950.4_Missense_Mutation_p.P269S|SP100_ENST00000409897.1_Missense_Mutation_p.P234S	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	269					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CTGCCCGTTGCCCTGTGATGA	0.433000													27	81					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100385647	100385647	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100385647C>T	ENST00000542585.1	+	0	7261				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGCCCCTCCTCGTGGAAGGAC	0.557000													19	52					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237374332	237374332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:237374332C>T	ENST00000409907.3	-	6	1016	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K	IQCA1_ENST00000309507.5_Missense_Mutation_p.E244K|IQCA1_ENST00000431676.2_Missense_Mutation_p.E248K			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	248							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						GCACTGACTTCATTAAAGAGA	0.418000													4	18					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111441412	111441412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111441412C>T	ENST00000265162.5	+	10	1959	c.1617C>T	c.(1615-1617)acC>acT	p.T539T		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	539					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ACACCTGGACCAGACAGATGG	0.403000													30	77					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43893738	43893738	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43893738G>A	ENST00000450892.2	-	24	4634	c.4557C>T	c.(4555-4557)ccC>ccT	p.P1519P	STRC_ENST00000541030.1_Silent_p.P746P	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1519					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ATCCCCGGGGGGGACCCCACA	0.527000													21	60					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1325381	1325381	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1325381G>A	ENST00000381567.3	-	3	293	c.294C>T	c.(292-294)tcC>tcT	p.S98S	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Silent_p.S98S	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	98						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CATTCCTGATGGAGAAATAGA	0.507000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								19	98					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383057	22383057	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22383057G>A	ENST00000328795.4	+	1	676	c.585G>A	c.(583-585)gtG>gtA	p.V195V	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTTTGTGGTGGAGCTTCTAA	0.527000													15	66					0	0	1	0	0
SERPIND1	3053	broad.mit.edu	37	22	21141196	21141196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21141196G>A	ENST00000215727.5	+	5	1625	c.1342G>A	c.(1342-1344)Gaa>Aaa	p.E448K	SERPIND1_ENST00000406799.1_Missense_Mutation_p.E448K|PI4KA_ENST00000466162.1_Intron|PI4KA_ENST00000572273.1_Intron|PI4KA_ENST00000255882.6_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	448					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	AGTGAACGAGGAAGGCACCCA	0.547000													41	115					0	0	1	0	0
APOL6	80830	broad.mit.edu	37	22	36055574	36055574	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36055574G>A	ENST00000409652.3	+	3	1239	c.963G>A	c.(961-963)agG>agA	p.R321R		NM_030641.3	NP_085144.1	Q9BWW8	APOL6_HUMAN	apolipoprotein L, 6	321					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity			haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						AGGAGTTAAGGGAGCATGTGT	0.507000													10	58					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25961910	25961910	+	Silent	SNP	G	G	A	rs139636096		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25961910G>A	ENST00000356865.6	-	9	1854	c.1743C>T	c.(1741-1743)gtC>gtT	p.V581V		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	581					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		ACGTGACGACGACTGTGTTGC	0.587000													13	150					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131864654	131864654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131864654G>A	ENST00000359827.3	-	20	4628	c.3666C>T	c.(3664-3666)tcC>tcT	p.S1222S	PLXNA4_ENST00000321063.4_Silent_p.S1222S			Q9HCM2	PLXA4_HUMAN	plexin A4	1222	IPT/TIG 4.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCATCCCCGGGGAGTACTCCA	0.647000													8	26					0	0	1	0	0
LMOD2	442721	broad.mit.edu	37	7	123302375	123302375	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123302375C>T	ENST00000458573.2	+	2	892	c.735C>T	c.(733-735)ttC>ttT	p.F245F	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	245						cytoskeleton	actin binding|tropomyosin binding										TGAAGACGTTCAGTCTGGCCA	0.498000													7	47					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40330368	40330368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40330368G>A	ENST00000264661.3	-	3	770	c.438C>T	c.(436-438)ggC>ggT	p.G146G	KCNH4_ENST00000607371.1_Silent_p.G146G	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	146					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGTCCCCGCGGCCTCCTTGGG	0.567000													21	22					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619175	57619175	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57619175C>T	ENST00000349394.5	+	2	747	c.572C>T	c.(571-573)cCc>cTc	p.P191L	NXPH4_ENST00000555154.1_3'UTR	NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	191	IV (linker domain).				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						GGGCTGGGGCCCCCGCTGGGG	0.756000													20	40					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51507373	51507373	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51507373G>A	ENST00000396402.1	-	8	1068	c.915C>T	c.(913-915)atC>atT	p.I305I	CYP19A1_ENST00000559878.1_Silent_p.I305I|CYP19A1_ENST00000260433.2_Silent_p.I305I|RP11-108K3.1_ENST00000559909.1_lincRNA|CYP19A1_ENST00000396404.4_Silent_p.I305I	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	305					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	CAGGAGCTGCGATCAGCATTT	0.403000													20	78					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63059013	63059013	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63059013G>A	ENST00000332793.6	+	2	406	c.402_splice	c.e2-1	p.W135_splice	SLC22A10_ENST00000526800.1_Splice_Site_p.W83_splice|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_5'UTR	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	135						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTCTTCCAGTGGGACCTGGTA	0.468000													16	44					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855900	12855900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12855900C>T	ENST00000332296.7	+	4	1283	c.1180C>T	c.(1180-1182)Ctg>Ttg	p.L394L	PRAMEF1_ENST00000400814.3_Silent_p.L149L	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	394										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TATTGACGCCCTGAAGGACCT	0.552000													43	206					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34666412	34666412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34666412G>A	ENST00000488417.1	+	3	1169	c.1049G>A	c.(1048-1050)gGg>gAg	p.G350E	C1orf94_ENST00000373374.3_Missense_Mutation_p.G160E	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	160							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AAGGGTCAAGGGAGCCTCTTT	0.597000													40	89					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248813251	248813251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248813251C>T	ENST00000344889.3	-	1	934	c.935G>A	c.(934-936)gGa>gAa	p.G312E		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGTTACCTTTCCTGAGGACAC	0.428000													23	60					0	0	1	0	0
IGKV1-8	28942	broad.mit.edu	37	2	89291972	89291972	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89291972C>T	ENST00000495489.1	-	0	353																											GCAAAATCTTCAGACTGCAGG	0.478000													66	189					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488296	108488296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108488296G>A	ENST00000408999.3	+	20	3913	c.3836G>A	c.(3835-3837)aGa>aAa	p.R1279K	RGPD4_ENST00000354986.4_Missense_Mutation_p.R1279K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1279					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AGCCCTGTGAGAAAAAATCTT	0.393000													122	338					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73839265	73839265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73839265G>A	ENST00000207549.4	-	3	615	c.236C>T	c.(235-237)tCt>tTt	p.S79F	UNC13D_ENST00000412096.2_Missense_Mutation_p.S79F|UNC13D_ENST00000587504.1_5'UTR	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	79					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGCAGCTCAGAGGCCTCCGT	0.672000									Familial Hemophagocytic Lymphohistiocytosis				21	39					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31133827	31133827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31133827G>A	ENST00000349752.5	-	15	2238	c.1599C>T	c.(1597-1599)atC>atT	p.I533I	GALNT14_ENST00000406653.1_Silent_p.I513I|GALNT14_ENST00000356174.3_Silent_p.I500I|GALNT14_ENST00000324589.5_Silent_p.I538I|GALNT14_ENST00000420311.2_Silent_p.I498I|GALNT14_ENST00000486564.1_5'UTR	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	533	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					GGTTGACGACGATTTCCTTGC	0.557000													27	67					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390399	197390399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197390399G>A	ENST00000367400.3	+	6	1576	c.1441G>A	c.(1441-1443)Gaa>Aaa	p.E481K	CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000544212.1_5'UTR|CRB1_ENST00000538660.1_Missense_Mutation_p.E481K|CRB1_ENST00000367399.2_Missense_Mutation_p.E369K|CRB1_ENST00000543483.1_Missense_Mutation_p.E180K|CRB1_ENST00000535699.1_Missense_Mutation_p.E412K|CRB1_ENST00000476483.1_3'UTR	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	481	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GTCCCTGTGTGAAATCGCAAC	0.498000													6	73					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135386427	135386427	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:135386427C>T	ENST00000354042.4	-	7	1401		c.e7+1			NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4							integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						CGTTCTATTACCTGGGATGGG	0.512000													21	48					0	0	1	0	0
IL1RN	3557	broad.mit.edu	37	2	113890408	113890408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113890408G>A	ENST00000361779.3	+	6	737	c.392G>A	c.(391-393)gGc>gAc	p.G131D	IL1RN_ENST00000409930.3_Missense_Mutation_p.G165D|IL1RN_ENST00000409052.1_Missense_Mutation_p.G131D|IL1RN_ENST00000354115.2_Missense_Mutation_p.G147D|IL1RN_ENST00000259206.5_Missense_Mutation_p.G168D	NM_173843.2	NP_776215.1	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist	165					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	10					Anakinra(DB00026)	CCTGACGAAGGCGTCATGGTC	0.587000									Lichen Sclerosis et Atrophicus, Familial Clustering of				24	113					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41416085	41416085	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41416085C>T	ENST00000400454.1	-	31	5780	c.5303G>A	c.(5302-5304)tGg>tAg	p.W1768*		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1768					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGCAGCCTCCAGTCTGTGGT	0.617000													36	92					0	0	1	0	0
CARKD	55739	broad.mit.edu	37	13	111277611	111277611	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111277611C>T	ENST00000309957.2	+	4	386	c.372C>T	c.(370-372)atC>atT	p.I124I	CARKD_ENST00000424185.2_Intron|CARKD_ENST00000397191.4_Intron|CARKD_ENST00000470164.2_Intron|CARKD_ENST00000458711.2_Intron	NM_001242881.1|NM_018210.3	NP_001229810.1|NP_060680.2	Q8IW45	CARKD_HUMAN	carbohydrate kinase domain containing	124	YjeF C-terminal.									NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	15						CGGAGCTGATCGTCCACCCAG	0.592000													8	31					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102067320	102067320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102067320G>A	ENST00000549145.1	+	25	2847	c.2747G>A	c.(2746-2748)aGg>aAg	p.R916K	MYBPC1_ENST00000360610.2_Missense_Mutation_p.R903K|MYBPC1_ENST00000541119.1_Missense_Mutation_p.R873K|MYBPC1_ENST00000536007.1_Missense_Mutation_p.R866K|MYBPC1_ENST00000553190.1_Missense_Mutation_p.R885K|MYBPC1_ENST00000547509.1_Missense_Mutation_p.R871K|MYBPC1_ENST00000547405.1_Missense_Mutation_p.R859K|MYBPC1_ENST00000545503.2_Missense_Mutation_p.R885K|MYBPC1_ENST00000441232.1_Missense_Mutation_p.R903K|MYBPC1_ENST00000392934.3_Missense_Mutation_p.R872K|MYBPC1_ENST00000361685.2_Missense_Mutation_p.R910K|MYBPC1_ENST00000361466.2_Missense_Mutation_p.R910K|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000551300.1_Missense_Mutation_p.R786K|MYBPC1_ENST00000550270.1_Missense_Mutation_p.R903K|MYBPC1_ENST00000452455.2_Missense_Mutation_p.R903K			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	903	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						AAAGCAGAGAGGAGCCACTCT	0.388000													84	178					0	0	1	0	0
NFAM1	150372	broad.mit.edu	37	22	42807656	42807656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42807656G>A	ENST00000329021.5	-	2	245	c.208C>T	c.(208-210)Cca>Tca	p.P70S		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	70	Ig-like V-type.				B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			large_intestine(1)|lung(3)	4						GGAGTGTATGGATAGGTGATC	0.547000													38	65					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984100	85984100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85984100C>T	ENST00000372113.4	-	2	886	c.881G>A	c.(880-882)aGa>aAa	p.R294K	LRIT2_ENST00000538192.1_Missense_Mutation_p.R294K	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	294	Ig-like.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						ATCAAATTCTCTCCACATACT	0.512000													5	41					0	0	1	0	0
SRPX2	27286	broad.mit.edu	37	X	99925834	99925834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:99925834C>T	ENST00000373004.3	+	11	1676	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	416					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						GCTCCTACTTCAACATGGTGT	0.522000											OREG0019890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	26					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116960640	116960640	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:116960640A>T	ENST00000265441.3	-	2	590	c.291T>A	c.(289-291)ttT>ttA	p.F97L	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	97					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GGACCCTGCCAAAAAGGCTGT	0.577000													5	17					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113346511	113346511	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113346511G>A	ENST00000452357.2	+	2	541	c.351G>A	c.(349-351)gtG>gtA	p.V117V	OAS1_ENST00000553185.1_Silent_p.V117V|OAS1_ENST00000445409.2_Silent_p.V117V|OAS1_ENST00000202917.5_Silent_p.V117V|OAS1_ENST00000551241.1_Silent_p.V117V|RP1-71H24.1_ENST00000552784.1_RNA	NM_002534.2	NP_002525.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	117	Necessary for binding to dsRNA.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						CATTTTCCGTGAAGTTTGAGG	0.562000													14	53					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281283	49281283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:49281283C>T	ENST00000282018.3	+	1	333	c.330C>T	c.(328-330)gcC>gcT	p.A110A		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	110					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	GAGACCTGGCCTGCAGGATTA	0.453000													46	71					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56320560	56320560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56320560G>A	ENST00000443188.1	-	5	2126	c.1416C>T	c.(1414-1416)ccC>ccT	p.P472P	NLRP11_ENST00000589093.1_Silent_p.P472P|NLRP11_ENST00000592953.1_Silent_p.P373P|NLRP11_ENST00000360133.3_Silent_p.P472P|NLRP11_ENST00000589824.2_Silent_p.P472P	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	472							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGCTGCCTGAGGGGATCAGAT	0.398000													32	72					0	0	1	0	0
HSD17B3	3293	broad.mit.edu	37	9	99012059	99012059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:99012059G>A	ENST00000375263.3	-	6	510	c.463C>T	c.(463-465)Cat>Tat	p.H155Y	RP11-240L7.4_ENST00000448857.1_RNA|HSD17B3_ENST00000464104.1_5'UTR|HSD17B3_ENST00000375262.2_Missense_Mutation_p.H155Y	NM_000197.1	NP_000188.1	P37058	DHB3_HUMAN	hydroxysteroid (17-beta) dehydrogenase 3	155					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	ATGTTACAATGGATGAGGCTC	0.398000													15	52					0	0	1	0	0
FAM120C	54954	broad.mit.edu	37	X	54159224	54159224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54159224G>A	ENST00000375180.2	-	9	2019	c.1963C>T	c.(1963-1965)Cgg>Tgg	p.R655W	FAM120C_ENST00000328235.4_Missense_Mutation_p.R655W	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	655										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CGAGCTGACCGGAATAAGAGA	0.488000													9	13					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41148164	41148164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41148164G>A	ENST00000344051.4	+	9	1474	c.1240G>A	c.(1240-1242)Gaa>Aaa	p.E414K	SPINT1_ENST00000431806.1_Missense_Mutation_p.E398K|SPINT1_ENST00000562057.1_Missense_Mutation_p.E398K			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	414	BPTI/Kunitz inhibitor 2.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		CCCCTTCAGCGAACACTGCGC	0.577000													113	72					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132158506	132158506	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132158506G>A	ENST00000378679.3	-	10	3345	c.2541C>T	c.(2539-2541)ttC>ttT	p.F847F	SHROOM1_ENST00000319854.3_Silent_p.F842F|SHROOM1_ENST00000378676.1_Silent_p.F778F	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	847					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAGAAGAGGGAAGGGCGGCT	0.607000													8	17					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57334198	57334198	+	Missense_Mutation	SNP	C	C	T	rs142091870	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57334198C>T	ENST00000326441.9	-	6	851	c.488G>A	c.(487-489)cGg>cAg	p.R163Q	ZIM2_ENST00000221722.5_Missense_Mutation_p.R38Q|ZIM2_ENST00000601070.1_Missense_Mutation_p.R38Q|ZIM2_ENST00000599935.1_Missense_Mutation_p.R38Q|PEG3_ENST00000598410.1_Missense_Mutation_p.R38Q|PEG3_ENST00000593695.1_Missense_Mutation_p.R37Q|ZIM2_ENST00000593931.1_Missense_Mutation_p.R38Q|ZIM2_ENST00000593711.1_Missense_Mutation_p.R38Q|ZIM2_ENST00000391708.3_Missense_Mutation_p.R38Q|PEG3_ENST00000423103.2_Missense_Mutation_p.R163Q	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	163					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTCCCAGTCCCGGTCACCTAA	0.532000													10	16					0	0	1	0	0
POLL	27343	broad.mit.edu	37	10	103345860	103345860	+	Missense_Mutation	SNP	G	G	A	rs61757734	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103345860G>A	ENST00000370162.3	-	3	663	c.169C>T	c.(169-171)Cgg>Tgg	p.R57W	POLL_ENST00000370172.1_5'UTR|POLL_ENST00000370158.3_Intron|POLL_ENST00000299206.4_Missense_Mutation_p.R57W|DPCD_ENST00000416979.2_Intron|POLL_ENST00000436284.2_5'UTR|POLL_ENST00000456836.2_Intron|POLL_ENST00000370169.1_Missense_Mutation_p.R57W|DPCD_ENST00000470165.1_Intron|POLL_ENST00000339310.3_Intron	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	57	BRCT.				DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		AGTTCTGCCCGGGCTCGTCCA	0.537000								DNA polymerases (catalytic subunits)					18	43					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635089	33635089	+	Missense_Mutation	SNP	G	G	A	rs150287359		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33635089G>A	ENST00000380099.3	+	4	1881	c.1873G>A	c.(1873-1875)Gag>Aag	p.E625K	KL_ENST00000426690.2_3'UTR|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	625	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CATGGCCAGCGAGCTTGTCCG	0.627000													13	85					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915400	119915400	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:119915400G>A	ENST00000331113.4	+	1	1679	c.714G>A	c.(712-714)atG>atA	p.M238I		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	238					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CCTGCGTCATGATCTTCACAG	0.542000													11	44					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37454063	37454063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37454063G>A	ENST00000374660.1	+	18	1975	c.1876G>A	c.(1876-1878)Gaa>Aaa	p.E626K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E626K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E626K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	682						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GGACTATGAAGAAAATTCTTG	0.289000													41	65					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24802755	24802755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24802755C>T	ENST00000395799.3	+	6	2921	c.2792C>T	c.(2791-2793)tCt>tTt	p.S931F	TNRC6A_ENST00000315183.7_Missense_Mutation_p.S931F	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	931	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TCTAATCAGTCTCTAGGTTGG	0.468000													26	57					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2542537	2542537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2542537G>A	ENST00000358864.1	+	4	450	c.435G>A	c.(433-435)ggG>ggA	p.G145G		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	145	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CCTCTGGTGGGGAGTCCCTGT	0.617000													24	64					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89525033	89525033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89525033C>T	ENST00000370473.4	-	4	614	c.395G>A	c.(394-396)gGa>gAa	p.G132E		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	132					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GTTGATGGTTCCTATGCTATT	0.527000													43	158					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458979	45458979	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45458979C>T	ENST00000548424.1	+	0	448																											CCTTGTATTTCCCCAGCTCAT	0.433000													12	28					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55976645	55976645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55976645C>T	ENST00000263923.4	-	9	1475	c.1180G>A	c.(1180-1182)Gga>Aga	p.G394R		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	394	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTGTAATTTCCTGTGTCTCTT	0.408000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			31	59					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179535006	179535006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179535006C>T	ENST00000589042.1	-	157	35549	c.35325G>A	c.(35323-35325)aaG>aaA	p.K11775K	TTN_ENST00000342992.6_Silent_p.K10474K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.K11401K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9894	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACAATTTTCTTAGGCACCT	0.313000													5	14					0	0	1	0	0
ART1	417	broad.mit.edu	37	11	3681454	3681454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3681454C>T	ENST00000250693.1	+	3	806	c.705C>T	c.(703-705)ttC>ttT	p.F235F		NM_004314.2	NP_004305.2	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1	235					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|skin(1)	8		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	ACTCCTTCTTCCCTGGAGAGG	0.612000													34	64					0	0	1	0	0
HACE1	57531	broad.mit.edu	37	6	105198317	105198317	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:105198317G>A	ENST00000262903.4	-	20	2518	c.2242C>T	c.(2242-2244)Cga>Tga	p.R748*	HACE1_ENST00000369125.2_Nonsense_Mutation_p.R533*|HACE1_ENST00000517995.1_5'UTR	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	748	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		CTTGTCATTCGAAGTTCAGTA	0.348000													14	20					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125874326	125874326	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125874326G>A	ENST00000393434.2	-	5	898	c.549C>T	c.(547-549)atC>atT	p.I183I	ALDH1L1_ENST00000393431.2_Silent_p.I183I|ALDH1L1_ENST00000472186.1_Silent_p.I183I|ALDH1L1_ENST00000452905.2_Intron|ALDH1L1_ENST00000273450.3_Silent_p.I193I|ALDH1L1_ENST00000455064.2_Silent_p.I8I|ALDH1L1_ENST00000413612.1_5'UTR	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	183	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TGCCCTCAGCGATCAGCCTCA	0.627000													17	37					0	0	1	0	0
HRH2	3274	broad.mit.edu	37	5	175111263	175111263	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:175111263C>T	ENST00000231683.2	+	1	2800	c.1027C>T	c.(1027-1029)Cag>Tag	p.Q343*	HRH2_ENST00000377291.2_Nonsense_Mutation_p.Q343*	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	343					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CCTGAAGCTCCAGGTGTGGAG	0.597000													45	132					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113538641	113538641	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113538641G>A	ENST00000505019.1	-	6	2682	c.2557C>T	c.(2557-2559)Cag>Tag	p.Q853*	C4orf21_ENST00000309071.5_Nonsense_Mutation_p.Q853*|C4orf21_ENST00000445203.2_Nonsense_Mutation_p.Q822*	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	853										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GTTCCTTGCTGAAAGACAGTA	0.348000													24	77					0	0	1	0	0
FABP3	2170	broad.mit.edu	37	1	31840289	31840289	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:31840289C>T	ENST00000373713.2	-	3	360	c.299G>A	c.(298-300)gGg>gAg	p.G100E	FABP3_ENST00000497275.1_5'UTR	NM_004102.3	NP_004093.1	P05413	FABPH_HUMAN	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	100					negative regulation of cell proliferation					large_intestine(1)|lung(2)|ovary(2)	5		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0185)|READ - Rectum adenocarcinoma(331;0.149)		GGTCTCTTGCCCGTCCCATTT	0.473000													81	193					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142180806	142180806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142180806G>A	ENST00000350721.4	-	42	7289	c.7168C>T	c.(7168-7170)Ctg>Ttg	p.L2390L	ATR_ENST00000383101.3_Silent_p.L2326L	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2390	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						AGTTTGGTCAGAATAGGTCTC	0.303000								Other conserved DNA damage response genes					71	227					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964551	119964551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119964551G>A	ENST00000543831.1	+	4	676	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	HSD3B2_ENST00000369416.3_Missense_Mutation_p.E143K	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	143					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CGGCCACGAAGAAGAGCCTCT	0.527000													32	146					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156635978	156635978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156635978C>T	ENST00000422843.3	+	2	369	c.217C>T	c.(217-219)Cca>Tca	p.P73S	CTB-4E7.1_ENST00000519375.1_RNA	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	73	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCAGCATCCCATGCCACTA	0.498000			T	SYK	peripheral T-cell lymphoma								4	54					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4432135	4432135	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4432135C>T	ENST00000301280.5	+	12	2235	c.2134C>T	c.(2134-2136)Ctg>Ttg	p.L712L	CHAF1A_ENST00000587368.1_3'UTR	NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	712	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCCTGCTTCCTGGAGACCCT	0.662000								Chromatin Structure					12	44					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153660163	153660163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153660163G>A	ENST00000368680.3	+	14	2618	c.2146G>A	c.(2146-2148)Ggc>Agc	p.G716S		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	716	Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CCCTGTGCGGGGCTCCCAGGC	0.597000													43	125					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132529451	132529451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:132529451C>T	ENST00000333577.4	+	38	6954	c.6845C>T	c.(6844-6846)cCt>cTt	p.P2282L	EP400_ENST00000330386.6_Missense_Mutation_p.P2165L|EP400_ENST00000389562.2_Missense_Mutation_p.P2245L|EP400_ENST00000332482.4_Missense_Mutation_p.P2209L|EP400_ENST00000389561.2_Missense_Mutation_p.P2246L			Q96L91	EP400_HUMAN	E1A binding protein p400	2282					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		AAGCTGCCCCCTGTGTACGTG	0.627000													27	45					0	0	1	0	0
FAM81A	145773	broad.mit.edu	37	15	59799517	59799517	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:59799517G>A	ENST00000288228.5	+	5	706	c.519G>A	c.(517-519)acG>acA	p.T173T		NM_152450.2	NP_689663.2	Q8TBF8	FA81A_HUMAN	family with sequence similarity 81, member A	173										endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10						TCTTGGAAACGAAAATCAAAG	0.433000													4	23					0	0	1	0	0
NOX1	27035	broad.mit.edu	37	X	100105173	100105173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:100105173C>T	ENST00000372966.3	-	9	1305	c.1100G>A	c.(1099-1101)aGg>aAg	p.R367K	NOX1_ENST00000372960.4_Missense_Mutation_p.R330K|NOX1_ENST00000372964.1_Intron|NOX1_ENST00000217885.5_Missense_Mutation_p.R367K	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	367	FAD-binding FR-type.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						TTCGAAAGCCCTTATGAGATT	0.473000													13	25					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72407608	72407608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72407608G>A	ENST00000359373.5	-	23	4109	c.3258C>T	c.(3256-3258)atC>atT	p.I1086I	ARAP1_ENST00000393605.3_Silent_p.I846I|ARAP1_ENST00000426523.1_Silent_p.I841I|ARAP1_ENST00000429686.1_Silent_p.I780I|ARAP1_ENST00000334211.8_Silent_p.I841I|ARAP1_ENST00000455638.2_Silent_p.I1086I|ARAP1_ENST00000393609.3_Silent_p.I1086I|ARAP1_ENST00000495878.1_5'UTR			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	1086	Rho-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						ACAGGTGGCTGATAAGGGCCT	0.602000													14	46					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136294	40136294	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:40136294G>A	ENST00000278198.2	-	2	3512	c.1549C>T	c.(1549-1551)Cca>Tca	p.P517S	LRRC4C_ENST00000528697.1_Missense_Mutation_p.P517S|LRRC4C_ENST00000530763.1_Missense_Mutation_p.P517S|LRRC4C_ENST00000527150.1_Missense_Mutation_p.P517S			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	517					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				TCAATTCCTGGGATCCCACTG	0.473000													24	32					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167471	140167471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140167471G>A	ENST00000458420.3	+	6	1088	c.898G>A	c.(898-900)Gag>Aag	p.E300K		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	300					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GATCGTCACAGAGCTGCAGAC	0.527000										HNSCC(16;0.037)			40	111					0	0	1	0	0
POMT2	29954	broad.mit.edu	37	14	77778331	77778331	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77778331G>A	ENST00000261534.4	-	2	496	c.294C>T	c.(292-294)aaC>aaT	p.N98N		NM_013382.5	NP_037514.2	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	98					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		AAAATGTACGGTTGATATAGT	0.418000													8	55					0	0	1	0	0
SPAG7	9552	broad.mit.edu	37	17	4864138	4864138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4864138G>A	ENST00000575142.1	-	2	81	c.63C>T	c.(61-63)gcC>gcT	p.A21A	SPAG7_ENST00000206020.3_Silent_p.A32A|SPAG7_ENST00000573366.1_5'UTR			O75391	SPAG7_HUMAN	sperm associated antigen 7	32						nucleus	nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(3)|ovary(2)|urinary_tract(1)	10						TCTTCAGGCGGGCGGCCTGTT	0.502000													26	62					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83362658	83362658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:83362658G>A	ENST00000262752.2	-	13	1091	c.1084C>T	c.(1084-1086)Cct>Tct	p.P362S	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.P362S	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	362	AGC-kinase C-terminal.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						GTAAATTCAGGATCAAAACAA	0.303000													11	18					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65241864	65241864	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65241864G>A	ENST00000389722.3	-	22	4874	c.4821C>T	c.(4819-4821)gtC>gtT	p.V1607V	SPTB_ENST00000556626.1_Silent_p.V1607V|SPTB_ENST00000542895.1_Silent_p.V1607V|SPTB_ENST00000389721.5_Silent_p.V1607V|SPTB_ENST00000389720.3_Silent_p.V1607V	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1607					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CATCGGAGATGACGTAGAGCT	0.622000													15	136					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990959	39990959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39990959C>T	ENST00000332312.3	-	4	1442	c.1250G>A	c.(1249-1251)gGg>gAg	p.G417E		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	417						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				AAGCTCATCCCCGGCCGGGGC	0.642000													7	106					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24411015	24411015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24411015C>T	ENST00000330966.7	-	16	2078	c.1916G>A	c.(1915-1917)cGg>cAg	p.R639Q	MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Missense_Mutation_p.R638Q|MYOM3_ENST00000374434.3_Missense_Mutation_p.R638Q|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	638	Fibronectin type-III 3.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CCCCACCTTCCGGGAGTAGAT	0.512000													20	174					0	0	1	0	0
SPATA31A2	642265	broad.mit.edu	37	9	39888172	39888172	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:39888172G>A	ENST00000456183.2	+	4	1188	c.1159G>A	c.(1159-1161)Gag>Aag	p.E387K		NM_001040065.1	NP_001035154.1			SPATA31 subfamily A, member 2																		GAACATGGGAGAGAACTCGAA	0.478000													45	42					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48615797	48615797	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48615797C>T	ENST00000328333.8	-	64	5596	c.5487_splice	c.e64-1	p.G1830_splice	COL7A1_ENST00000454817.1_Splice_Site_p.G1830_splice	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1830	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCTGGCTTTCCCTGTGGGAA	0.562000													28	76					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124381320	124381320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124381320G>A	ENST00000287394.5	-	8	1134	c.1027C>T	c.(1027-1029)Cct>Tct	p.P343S	ATAD2_ENST00000534257.1_5'UTR|ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TTACAGTAAGGACTTCTTGGT	0.403000													22	44					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3351177	3351177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3351177C>T	ENST00000520002.1	-	12	1974	c.1419G>A	c.(1417-1419)ggG>ggA	p.G473G	CSMD1_ENST00000542608.1_Silent_p.G472G|CSMD1_ENST00000400186.3_Silent_p.G473G|CSMD1_ENST00000602557.1_Silent_p.G473G|CSMD1_ENST00000537824.1_Silent_p.G472G|CSMD1_ENST00000602723.1_Silent_p.G473G|CSMD1_ENST00000539096.1_Silent_p.G472G			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	473	CUB 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCCCACCTTCCCAGCATCAC	0.507000													12	8					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155761161	155761161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155761161G>A	ENST00000159060.2	-	6	699	c.597C>T	c.(595-597)tcC>tcT	p.S199S		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	199	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		ACAACTCATAGGAGGCCTGTC	0.507000													27	38					0	0	1	0	0
ZNF461	92283	broad.mit.edu	37	19	37130142	37130142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37130142G>A	ENST00000588268.1	-	6	1332	c.1105C>T	c.(1105-1107)Cgc>Tgc	p.R369C	ZNF461_ENST00000540605.2_5'UTR|ZNF461_ENST00000360357.4_Missense_Mutation_p.R346C	NM_153257.2	NP_694989.2	Q8TAF7	ZN461_HUMAN	zinc finger protein 461	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGATGTGAGCGATGCCTAAAA	0.418000													25	62					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101865215	101865215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101865215C>T	ENST00000348070.1	-	18	2213	c.2214G>A	c.(2212-2214)ggG>ggA	p.G738G	PCSK6_ENST00000358417.3_Silent_p.G725G|PCSK6_ENST00000561177.1_5'UTR	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	739	CRM (Cys-rich motif).				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTGCTGTGTCCCCAAAGTAGC	0.657000													26	23					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12336400	12336400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12336400C>T	ENST00000358136.3	+	19	2885	c.2755C>T	c.(2755-2757)Ccc>Tcc	p.P919S	VPS13D_ENST00000356315.4_Missense_Mutation_p.P919S	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	919					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAAGATTTTTCCCCAGGAGGA	0.438000											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	42					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854285	12854285	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12854285G>A	ENST00000332296.7	+	3	612	c.509G>A	c.(508-510)tGg>tAg	p.W170*		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	170								p.W170L(2)		cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTTCCAGTGGGTTTACCAA	0.433000													49	636					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451962	138451962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138451962C>T	ENST00000344876.4	-	1	1667	c.1281G>A	c.(1279-1281)aaG>aaA	p.K427K	PCDH18_ENST00000507846.1_Silent_p.K207K|PCDH18_ENST00000412923.2_Silent_p.K427K|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	427	Cadherin 4.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ACTCAGATCTCTTTTCTCTAT	0.353000													44	111					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366642	248366642	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248366642C>T	ENST00000456743.1	+	1	311	c.273C>T	c.(271-273)tcC>tcT	p.S91S		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S91S(1)		endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCAGCAAGTCCATTTCTATGG	0.498000													156	394					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926512	157926512	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157926512C>T	ENST00000389413.3	-	9	1516	c.1413G>A	c.(1411-1413)ggG>ggA	p.G471G	PTPRN2_ENST00000409483.1_Silent_p.G433G|PTPRN2_ENST00000404321.2_Silent_p.G494G|PTPRN2_ENST00000389416.4_Silent_p.G454G|PTPRN2_ENST00000389418.4_Silent_p.G471G	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	471						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TTTGGAGCTCCCCAAACGCAG	0.637000													25	71					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233335967	233335967	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233335967G>A	ENST00000258229.8	-	14	3141	c.2907C>T	c.(2905-2907)ttC>ttT	p.F969F	PCNXL2_ENST00000488780.2_Silent_p.F102F	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	969						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TGATTTGCGGGAAGAGCCCAA	0.398000													9	10					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68192613	68192613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68192613G>A	ENST00000294304.7	+	15	3386	c.3280G>A	c.(3280-3282)Gaa>Aaa	p.E1094K		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1094	Beta-propeller 4.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AGCCAAGATCGAACGCGCAGC	0.657000													13	65					0	0	1	0	0
C12orf77	196415	broad.mit.edu	37	12	25148783	25148783	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25148783T>A	ENST00000549828.1	-	3	569	c.365A>T	c.(364-366)aAa>aTa	p.K122I	C12orf77_ENST00000434912.3_Missense_Mutation_p.K67I|C12orf77_ENST00000549262.1_Missense_Mutation_p.K67I	NM_001101339.1	NP_001094809.1	C9JDV5	CL097_HUMAN	chromosome 12 open reading frame 77	122										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	7						TGGGTTTCTTTTTGTAAAGTC	0.408000													20	40					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118624248	118624248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:118624248C>T	ENST00000336338.5	-	14	1845	c.1780G>A	c.(1780-1782)Gaa>Aaa	p.E594K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	594						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CGTTCTACTTCATTCCAGCTC	0.458000													31	102					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133789762	133789762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:133789762C>T	ENST00000367895.5	+	11	1327	c.863C>T	c.(862-864)tCa>tTa	p.S288L	EYA4_ENST00000531901.1_Missense_Mutation_p.S288L|EYA4_ENST00000355286.6_Missense_Mutation_p.S265L|EYA4_ENST00000525849.1_Missense_Mutation_p.S265L|EYA4_ENST00000355167.3_Missense_Mutation_p.S288L|EYA4_ENST00000452339.2_Missense_Mutation_p.S234L|EYA4_ENST00000431403.2_Missense_Mutation_p.S288L|EYA4_ENST00000430974.2_Missense_Mutation_p.S234L	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	288					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TATTCAGCATCAACGTATGGA	0.413000													47	68					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120172084	120172084	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120172084G>A	ENST00000392521.2	-	26	3290	c.3235C>T	c.(3235-3237)Cta>Tta	p.L1079L	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Silent_p.L1037L	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1037					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCTTTTTCTAGCAGCTCATCG	0.542000													23	74					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20634834	20634834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20634834G>A	ENST00000219151.4	-	14	1871	c.661C>T	c.(661-663)Cgg>Tgg	p.R221W	ACSM1_ENST00000520010.1_Missense_Mutation_p.R570W|ACSM1_ENST00000307493.4_Missense_Mutation_p.R570W			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	570					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TCCTTTTTCCGAAGTTCCTTC	0.488000													30	63					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248684977	248684977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248684977G>A	ENST00000343414.4	+	1	62	c.30G>A	c.(28-30)aaG>aaA	p.K10K		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTCTGAAAAGGGATTTCTTC	0.413000													34	162					0	0	1	0	0
FGGY	55277	broad.mit.edu	37	1	59844489	59844489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:59844489G>A	ENST00000371218.4	+	5	718	c.534G>A	c.(532-534)aaG>aaA	p.K178K	FGGY_ENST00000371212.1_Silent_p.K90K|FGGY_ENST00000474476.1_3'UTR|FGGY_ENST00000303721.7_Silent_p.K178K	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	178					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					TATCGTGGAAGGCAACAGGTG	0.383000													29	82					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52603771	52603771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52603771C>T	ENST00000395489.2	-	6	586	c.190G>A	c.(190-192)Gag>Aag	p.E64K	A1CF_ENST00000395495.1_Missense_Mutation_p.E71K|A1CF_ENST00000373993.1_Missense_Mutation_p.E71K|A1CF_ENST00000374001.1_Missense_Mutation_p.E71K|A1CF_ENST00000373995.3_Missense_Mutation_p.E79K|A1CF_ENST00000373997.3_Missense_Mutation_p.E71K|A1CF_ENST00000282641.2_Missense_Mutation_p.E71K	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	71	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GGTATAAGCTCATCCTCAAAA	0.388000													51	169					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	629674	629674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:629674C>T	ENST00000255622.6	+	3	670	c.627C>T	c.(625-627)ttC>ttT	p.F209F	PDE6B_ENST00000496514.1_Silent_p.F209F	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	209	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						TTCAGGTGTTCTTGAAGTACC	0.507000													17	48					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202777349	202777349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202777349G>A	ENST00000367265.3	-	1	1249	c.85C>T	c.(85-87)Cca>Tca	p.P29S	KDM5B_ENST00000367264.2_Missense_Mutation_p.P29S	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	29					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						CACTCGGGTGGAGGCAGGAAC	0.706000													22	42					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488815	20488815	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20488815C>T	ENST00000555186.1	+	0	298					NR_038836.1																						ATGTGGAACCCCCACCTGCTT	0.428000													17	132					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187542685	187542685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187542685G>A	ENST00000441802.2	-	10	5264	c.5055C>T	c.(5053-5055)ttC>ttT	p.F1685F		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1685	Cadherin 15.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CCATCCCAACGAAACTCCCAA	0.388000										HNSCC(5;0.00058)			24	76					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72324627	72324627	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72324627C>T	ENST00000389916.4	+	2	241	c.103C>T	c.(103-105)Cat>Tat	p.H35Y		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	35	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CCTCATCGCCCATAAAGTGGA	0.627000													4	12					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18257561	18257561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18257561G>A	ENST00000286479.3	+	2	155	c.48G>A	c.(46-48)agG>agA	p.R16R	NAT2_ENST00000520116.1_Intron	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	16					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		AGAACTCTAGGAACAAATTGG	0.378000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				68	150					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4920518	4920518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4920518C>T	ENST00000433855.1	+	1	2177	c.1311C>T	c.(1309-1311)atC>atT	p.I437I	KCNA6_ENST00000280684.3_Silent_p.I437I	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	437						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GGGGAAAGATCGTGGGCTCGC	0.592000										HNSCC(72;0.22)			25	69					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70071222	70071222	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70071222C>T	ENST00000370598.1	+	29	4878	c.4057C>T	c.(4057-4059)Ccc>Tcc	p.P1353S	BAI3_ENST00000546190.1_Missense_Mutation_p.P317S|BAI3_ENST00000238918.8_Missense_Mutation_p.P559S	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1353					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CAATATGAATCCCCCTGTAAT	0.423000													7	109					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439538	52439538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52439538G>A	ENST00000242819.4	+	2	320	c.24G>A	c.(22-24)ctG>ctA	p.L8L		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	8						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CATTCCGGCTGATAAGGAAGA	0.572000													30	58					0	0	1	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919888	142919888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142919888G>A	ENST00000408947.3	+	1	759	c.717G>A	c.(715-717)atG>atA	p.M239I		NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	239					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					ACCCCAGCATGAAGGCTCACA	0.498000													45	141					0	0	1	0	0
UGT1A6	54578	broad.mit.edu	37	2	234601708	234601708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234601708C>T	ENST00000305139.6	+	1	197	c.58C>T	c.(58-60)Ctt>Ttt	p.L20F	UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000373445.1_Intron	NM_001072.3	NP_001063.2														central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CTTCTTAGCACTTTGGGGCAT	0.483000													24	87					0	0	1	0	0
PRTFDC1	56952	broad.mit.edu	37	10	25160960	25160960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25160960G>A	ENST00000320152.6	-	4	400	c.372C>T	c.(370-372)atC>atT	p.I124I	PRTFDC1_ENST00000376378.1_Silent_p.I124I	NM_020200.5	NP_064585.1	Q9NRG1	PRDC1_HUMAN	phosphoribosyl transferase domain containing 1	124					adenine salvage|central nervous system neuron development|cerebral cortex neuron differentiation|cytolysis|dendrite morphogenesis|GMP salvage|grooming behavior|hypoxanthine metabolic process|IMP salvage|lymphocyte proliferation|positive regulation of dopamine metabolic process|purine ribonucleoside salvage|response to amphetamine|striatum development	cytosol	hypoxanthine phosphoribosyltransferase activity|magnesium ion binding|nucleotide binding|protein homodimerization activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	9						CATCGCCTCCGATTATCTGCA	0.453000													90	202					0	0	1	0	0
RNF145	153830	broad.mit.edu	37	5	158609049	158609049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:158609049G>A	ENST00000424310.2	-	4	663	c.304C>T	c.(304-306)Cgg>Tgg	p.R102W	RNF145_ENST00000518802.1_Missense_Mutation_p.R132W|RNF145_ENST00000519865.1_Missense_Mutation_p.R102W|RNF145_ENST00000520638.1_Missense_Mutation_p.R116W|RNF145_ENST00000521606.2_Missense_Mutation_p.R119W|RNF145_ENST00000274542.2_Missense_Mutation_p.R130W	NM_001199383.1	NP_001186312.1	Q96MT1	RN145_HUMAN	ring finger protein 145	102						integral to membrane	zinc ion binding			endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTTCACTCCGAACATAGTCC	0.318000													31	133					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961846	34961846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34961846C>T	ENST00000329357.5	+	1	934	c.898C>T	c.(898-900)Cct>Tct	p.P300S		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	300	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CCCGGAGCCTCCTGAGACTGG	0.632000													48	27					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56467057	56467057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56467057C>T	ENST00000291971.3	+	3	1704	c.1633C>T	c.(1633-1635)Ccc>Tcc	p.P545S	NLRP8_ENST00000590542.1_Missense_Mutation_p.P545S	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	545						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GATAGCGAGTCCCAGAGGAAG	0.458000													43	85					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6712357	6712357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6712357C>T	ENST00000245907.6	-	11	1272	c.1180G>A	c.(1180-1182)Gag>Aag	p.E394K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	394					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACAGTGTCCTCGCCCTGGACT	0.617000													21	48					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141600242	141600242	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141600242G>A	ENST00000442267.2	-	5	779	c.705C>T	c.(703-705)ttC>ttT	p.F235F		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	235						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TGATGTTGAGGAATACAGAGA	0.478000													58	157					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923060	24923060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24923060G>A	ENST00000329468.2	+	1	2520	c.2046G>A	c.(2044-2046)gtG>gtA	p.V682V		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCACTTTAGTGAACAGTGCCT	0.522000													67	187					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71027107	71027107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:71027107G>A	ENST00000318789.4	-	15	1745	c.1220C>T	c.(1219-1221)cCa>cTa	p.P407L	FOXP1_ENST00000491238.1_Missense_Mutation_p.P409L|FOXP1_ENST00000468577.1_Missense_Mutation_p.P407L|FOXP1_ENST00000484350.1_Missense_Mutation_p.P331L|FOXP1_ENST00000493089.1_Missense_Mutation_p.P407L|FOXP1_ENST00000498215.1_Missense_Mutation_p.P407L|FOXP1_ENST00000475937.1_Missense_Mutation_p.P407L	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	407					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TGGGGTCGTTGGAGTATGAGG	0.557000			T	PAX5	ALL								13	156					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46628458	46628458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46628458C>T	ENST00000470495.1	-	2	1981	c.534G>A	c.(532-534)ggG>ggA	p.G178G	HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000490677.1_Silent_p.G44G|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000489475.1_Silent_p.G105G|HOXB3_ENST00000485909.2_Silent_p.G46G|HOXB3_ENST00000311626.4_Silent_p.G178G|HOXB3_ENST00000498678.1_Silent_p.G178G|HOXB3_ENST00000476342.1_Silent_p.G178G|HOXB3_ENST00000472863.1_Silent_p.G105G|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Silent_p.G46G			P14651	HXB3_HUMAN	homeobox B3	178	Gly-rich.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						GGCTCTTGTCCCCTCCCccgc	0.756000													22	20					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68812269	68812269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68812269C>T	ENST00000508048.1	-	2	64	c.29G>A	c.(28-30)cGa>cAa	p.R10Q	TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.R11Q|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.R11Q			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	11					cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity	p.R11Q(1)		breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						ATTTCTGCTTCGGGTGCCAAA	0.488000													21	45					0	0	1	0	0
CHST1	8534	broad.mit.edu	37	11	45671526	45671526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:45671526G>A	ENST00000308064.2	-	4	1618	c.948C>T	c.(946-948)atC>atT	p.I316I		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	316					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GGAACCCGTAGATCTCCTCGG	0.642000													31	51					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32792919	32792919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32792919C>T	ENST00000380250.3	+	36	5212	c.4716C>T	c.(4714-4716)ctC>ctT	p.L1572L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACACTCGCCTCGAGTCAAGAT	0.413000													11	47					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79024751	79024751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79024751G>A	ENST00000446378.2	+	2	194	c.163G>A	c.(163-165)Gat>Aat	p.D55N		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	55	Glu-rich.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ATCAGACCAGGATGAAGAGGG	0.323000													17	31					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21958140	21958140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21958140G>A	ENST00000261201.4	-	38	4617	c.4618C>T	c.(4618-4620)Ctc>Ttc	p.L1540F	ABCC9_ENST00000261200.4_Intron|ABCC9_ENST00000345162.2_Missense_Mutation_p.L1504F	NM_005691.2	NP_005682.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1540	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTGGAAAAGAGGCCATTCTTG	0.423000													19	34					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18657708	18657708	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18657708G>A	ENST00000380548.4	+	8	1245	c.906G>A	c.(904-906)agG>agA	p.R302R	ADAMTSL1_ENST00000380566.4_Silent_p.R302R|ADAMTSL1_ENST00000276935.6_Silent_p.R302R|ADAMTSL1_ENST00000327883.7_Silent_p.R302R	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	302						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		ACCGATGGAGGGAGACGGATT	0.463000													8	38					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59113756	59113756	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:59113756C>T	ENST00000395153.3	+	4	2451	c.2304C>T	c.(2302-2304)ccC>ccT	p.P768P	DACT1_ENST00000541264.2_Silent_p.P524P|DACT1_ENST00000395151.3_Silent_p.P524P|DACT1_ENST00000335867.4_Silent_p.P805P|DACT1_ENST00000556859.1_Silent_p.P524P	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	805					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						ACAACCACCCCGCAAAAACCT	0.502000													30	99					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20850797	20850797	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20850797G>A	ENST00000262715.5	-	28	4165	c.4125C>T	c.(4123-4125)ttC>ttT	p.F1375F	TEP1_ENST00000556935.1_Silent_p.F1267F	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1375	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CATACAGCGTGAAGAGCCTCA	0.552000													29	70					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161729	57161729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57161729G>A	ENST00000371244.4	+	6	751	c.685G>A	c.(685-687)Ggt>Agt	p.G229S		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	229	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						GATCCGAGGGGGTGTCTTTTA	0.443000													38	345					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24448111	24448111	+	Missense_Mutation	SNP	C	C	T	rs146993893	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24448111C>T	ENST00000230036.1	-	17	1782	c.1672G>A	c.(1672-1674)Gac>Aac	p.D558N		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	558						extracellular region	glycosylphosphatidylinositol phospholipase D activity	p.D558N(1)		breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						CTACCTTTGTCGCTCAGGCTG	0.522000													16	31					0	0	1	0	0
SENP1	29843	broad.mit.edu	37	12	48457594	48457594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48457594G>A	ENST00000004980.5	-	13	1784	c.1306C>T	c.(1306-1308)Cgt>Tgt	p.R436C	SENP1_ENST00000549595.1_Missense_Mutation_p.R436C|SENP1_ENST00000549518.1_Missense_Mutation_p.R436C|SENP1_ENST00000339976.6_3'UTR|SENP1_ENST00000448372.1_Missense_Mutation_p.R436C|SENP1_ENST00000551330.1_Missense_Mutation_p.R436C			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	436					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				TTCCCATTACGAAATACATTC	0.383000													10	37					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151804206	151804206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151804206G>A	ENST00000318247.6	-	1	142	c.35C>T	c.(34-36)tCa>tTa	p.S12L	RORC_ENST00000392697.3_5'UTR	NM_005060.3	NP_005051.2	P51449	RORG_HUMAN	RAR-related orphan receptor C	12	Modulating (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTTACCCCGTGAGGCTCGGTG	0.662000													19	171					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42414957	42414957	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42414957C>T	ENST00000381668.5	-	37	3702	c.3471G>A	c.(3469-3471)acG>acA	p.T1157T	ATP8A1_ENST00000264449.10_Silent_p.T1142T	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	1157					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity	p.T1157T(1)		NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	GCCTCTGTTTCGTGGTATCAT	0.458000													17	46					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138683650	138683650	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138683650G>A	ENST00000298480.5	+	31	3647	c.3573G>A	c.(3571-3573)atG>atA	p.M1191I	KCNT1_ENST00000263604.3_Missense_Mutation_p.M1165I|KCNT1_ENST00000488444.2_Missense_Mutation_p.M1170I|KCNT1_ENST00000371757.2_Missense_Mutation_p.M1170I|KCNT1_ENST00000486577.2_Missense_Mutation_p.M1148I|KCNT1_ENST00000490355.2_Missense_Mutation_p.M1169I|KCNT1_ENST00000487664.1_Missense_Mutation_p.M1146I|KCNT1_ENST00000491806.2_Missense_Mutation_p.M1156I			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	1170						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CAGACGAGATGAACGACCACC	0.647000													30	103					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681066	142681066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142681066G>A	ENST00000340634.3	-	1	1112	c.1113C>T	c.(1111-1113)tcC>tcT	p.S371S		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	371						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						TGCAGAATTCGGAGCTGTTTA	0.527000													41	127					0	0	1	0	0
SUSD1	64420	broad.mit.edu	37	9	114874094	114874094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114874094G>A	ENST00000374270.3	-	8	1183	c.1011C>T	c.(1009-1011)gaC>gaT	p.D337D	SUSD1_ENST00000374264.2_Silent_p.D337D|SUSD1_ENST00000374263.3_Silent_p.D337D	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1	337						integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						ATTCCATAGGGTCCAACCGTT	0.507000													22	48					0	0	1	0	0
BCL2L10	10017	broad.mit.edu	37	15	52404827	52404827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52404827C>T	ENST00000260442.3	-	1	145	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	BCL2L10_ENST00000561198.1_Missense_Mutation_p.E33K	NM_020396.2	NP_065129.1	Q9HD36	B2L10_HUMAN	BCL2-like 10 (apoptosis facilitator)	23					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2				all cancers(107;0.0148)		GTGCCGGGTTCCCGGGCGCAG	0.716000													3	5					0	0	1	0	0
RBM33	155435	broad.mit.edu	37	7	155567726	155567726	+	Silent	SNP	C	C	T	rs139259621		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:155567726C>T	ENST00000401878.3	+	18	3702	c.3504C>T	c.(3502-3504)atC>atT	p.I1168I	RBM33_ENST00000341148.3_Silent_p.I104I	NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	1168	RRM.						nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		TGGCCCTGATCGTGGAGTGAG	0.502000													14	42					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10315987	10315987	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10315987G>A	ENST00000403437.2	-	13	1300	c.1206C>T	c.(1204-1206)ctC>ctT	p.L402L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	402	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TAGGGTAGCAGAGGGCTTTGA	0.502000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				96	142					0	0	1	0	0
CCP110	9738	broad.mit.edu	37	16	19547601	19547601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19547601C>T	ENST00000396212.2	+	5	1046	c.610C>T	c.(610-612)Ccc>Tcc	p.P204S	CCP110_ENST00000381396.5_Missense_Mutation_p.P204S|CCP110_ENST00000396208.2_Missense_Mutation_p.P204S	NM_014711.4	NP_055526.3	O43303	CP110_HUMAN	centriolar coiled coil protein 110kDa	204	CEP97 binding.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|stomach(3)|urinary_tract(1)	21						TTCTGATGGTCCCTTCTCAGT	0.393000													57	111					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78372553	78372553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78372553C>T	ENST00000278550.7	-	33	7954	c.7492G>A	c.(7492-7494)Gaa>Aaa	p.E2498K		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TAGGAGGGTTCCATGGCATCC	0.532000													9	13					0	0	1	0	0
S100A8	6279	broad.mit.edu	37	1	153362973	153362973	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153362973G>A	ENST00000368733.3	-	2	208	c.39C>T	c.(37-39)atC>atT	p.I13I	S100A8_ENST00000368732.1_Silent_p.I13I|S100A8_ENST00000477801.1_5'UTR	NM_002964.4	NP_002955.2	P05109	S10A8_HUMAN	S100 calcium binding protein A8	13	EF-hand 1.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGTAGACGTCGATGATAGAGT	0.498000													68	146					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27238925	27238925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27238925G>A	ENST00000222753.4	-	1	800	c.772C>T	c.(772-774)Ctc>Ttc	p.L258F	HOTTIP_ENST00000421733.1_RNA	NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	258					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						GGGCCCCCGAGGCCCGGCACC	0.657000			T	NUP98	AML								13	31					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101834561	101834561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101834561C>T	ENST00000263468.8	+	6	3065	c.2795C>T	c.(2794-2796)cCc>cTc	p.P932L	KIAA1377_ENST00000537689.1_Missense_Mutation_p.P733L	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	932							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAATCAGTTCCCTTATGGAAA	0.378000													49	114					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125621386	125621386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125621386C>T	ENST00000316519.6	+	17	2063	c.1857C>T	c.(1855-1857)ctC>ctT	p.L619L	AACS_ENST00000261686.6_Intron|AACS_ENST00000545511.1_Intron|AACS_ENST00000543665.1_Intron|AACS_ENST00000316543.10_Silent_p.L217L	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	619					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		TGCCCAGCCTCATCCTGGAAA	0.632000													20	44					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21225438	21225438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21225438C>T	ENST00000233242.1	-	29	12983	c.12856G>A	c.(12856-12858)Gcc>Acc	p.A4286T		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4286					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACTGAATGGCTTTAAATACC	0.348000													45	114					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6521818	6521818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6521818G>A	ENST00000377782.3	-	10	1024	c.957C>T	c.(955-957)ccC>ccT	p.P319P	TNFRSF25_ENST00000356876.3_Silent_p.P310P|TNFRSF25_ENST00000351748.3_Silent_p.P127P|TNFRSF25_ENST00000348333.3_Silent_p.P265P|TNFRSF25_ENST00000351959.5_Silent_p.P273P	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	310					apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GCGCAGCAGCGGGGCCTGGGG	0.716000													3	1					0	0	1	0	0
FRK	2444	broad.mit.edu	37	6	116288845	116288845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116288845G>A	ENST00000606080.1	-	4	1114	c.668C>T	c.(667-669)aCc>aTc	p.T223I	FRK_ENST00000538210.1_Missense_Mutation_p.T81I	NM_002031.2	NP_002022.1	P42685	FRK_HUMAN	fyn-related kinase	223					negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|skin(1)|urinary_tract(1)	27		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TTGGTCCACGGTTTTATACGA	0.388000													36	57					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51752037	51752037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51752037G>A	ENST00000543196.2	-	8	1582	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	GALNT6_ENST00000356317.3_Silent_p.F459F			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	459					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						AAATGTCACCGAAGGATTTCT	0.473000													44	117					0	0	1	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84872160	84872160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84872160C>T	ENST00000262424.5	+	2	283	c.59C>T	c.(58-60)tCc>tTc	p.S20F	CRISPLD2_ENST00000564567.1_Missense_Mutation_p.S20F|CRISPLD2_ENST00000566431.1_3'UTR|CRISPLD2_ENST00000569090.1_Missense_Mutation_p.S20F|CRISPLD2_ENST00000567845.1_Missense_Mutation_p.S20F	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	20						extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						GTCTGCGGATCCCAAGGCTAC	0.617000													30	86					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157494322	157494322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157494322G>A	ENST00000361835.3	-	10	2143	c.1986C>T	c.(1984-1986)acC>acT	p.T662T	FCRL5_ENST00000368190.3_Silent_p.T662T|FCRL5_ENST00000356953.4_Silent_p.T662T|FCRL5_ENST00000368191.3_Silent_p.T577T	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	662	Ig-like C2-type 7.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GAGCCCTGAAGGTGAGGATGG	0.507000													22	38					0	0	1	0	0
OR11H1	81061	broad.mit.edu	37	22	16449127	16449127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:16449127G>A	ENST00000252835.4	-	1	678	c.678C>T	c.(676-678)ttC>ttT	p.F226F		NM_001005239.1	NP_001005239.1	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H, member 1	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)	11	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		TAATAAAGAGGAAGTTACCAA	0.433000													56	119					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44102468	44102468	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44102468C>T	ENST00000259746.9	+	2	330	c.147C>T	c.(145-147)ttC>ttT	p.F49F	TMEM63B_ENST00000323267.6_Silent_p.F49F			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	49						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTCTCGACTTCATGTGCTTCC	0.607000													27	66					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176016169	176016169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176016169C>T	ENST00000510636.1	+	22	3268	c.2994C>T	c.(2992-2994)ttC>ttT	p.F998F	CDHR2_ENST00000261944.5_Silent_p.F998F|CDHR2_ENST00000506348.1_Silent_p.F998F	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	998	Cadherin 9.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CCGACGTGTTCGCTGGGAGCA	0.612000													60	162					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247752561	247752561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247752561G>A	ENST00000320065.1	+	1	900	c.900G>A	c.(898-900)gtG>gtA	p.V300V	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCAAGGAGGTGAAAGGGGCAT	0.368000													52	152					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99551856	99551856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:99551856G>A	ENST00000373034.4	-	6	4541	c.2866C>T	c.(2866-2868)Cat>Tat	p.H956Y	PCDH19_ENST00000420881.2_Missense_Mutation_p.H908Y|PCDH19_ENST00000255531.7_Missense_Mutation_p.H909Y	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	956					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.H956Y(1)|p.H409Y(1)		breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						TCCCGGCAATGAAATCCTTCA	0.473000													30	23					0	0	1	0	0
SF3B4	10262	broad.mit.edu	37	1	149899118	149899118	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149899118G>A	ENST00000271628.8	-	2	687	c.103C>T	c.(103-105)Cag>Tag	p.Q35*		NM_005850.4	NP_005841.1	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4, 49kDa	35	RRM 1.					nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			endometrium(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)	17	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GGTCCAGCCTGGAGAAACAGT	0.562000													15	83					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54805731	54805731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54805731C>T	ENST00000293379.4	-	2	497	c.236G>A	c.(235-237)gGa>gAa	p.G79E	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA|ITGA5_ENST00000547744.1_5'UTR	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	79					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CTTGGGTGCTCCCACCAGCAC	0.602000													11	25					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211521331	211521331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211521331C>T	ENST00000233072.5	+	30	3837	c.3641C>T	c.(3640-3642)aCc>aTc	p.T1214I	CPS1_ENST00000430249.2_Missense_Mutation_p.T1220I|CPS1_ENST00000451903.2_Missense_Mutation_p.T763I	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1214	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCCACACAAACCATCAGCCAA	0.403000													18	69					0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123664559	123664559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123664559C>T	ENST00000542236.1	+	3	1893	c.1512C>T	c.(1510-1512)ctC>ctT	p.L504L	BBS12_ENST00000314218.3_Silent_p.L504L	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	504					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						CGGCCGTGCTCACTAACCCAG	0.408000									Bardet-Biedl syndrome				31	97					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57420500	57420500	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57420500C>T	ENST00000543257.1	-	5	802	c.235_splice	c.e5-1	p.G79_splice	C8B_ENST00000371237.4_Splice_Site_p.G131_splice|C8B_ENST00000535057.1_Splice_Site_p.G69_splice	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	131	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TACACACCTTCCTAGAATGGA	0.433000													17	86					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169656259	169656259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169656259C>T	ENST00000428432.2	+	9	1695	c.1306C>T	c.(1306-1308)Cct>Tct	p.P436S	SAMD7_ENST00000335556.3_Missense_Mutation_p.P436S	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	436										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TACAATAATTCCTAAAGGAAT	0.398000													9	32					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8656696	8656696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8656696G>A	ENST00000595838.1	-	2	290	c.257C>T	c.(256-258)cCt>cTt	p.P86L	ADAMTS10_ENST00000270328.4_Silent_p.S595S|ADAMTS10_ENST00000597188.1_Silent_p.S595S			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	0					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CCGTGTTGCAGGAGCGGTGCC	0.612000													24	105					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56189956	56189956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56189956C>T	ENST00000340462.4	-	3	700	c.420G>A	c.(418-420)acG>acA	p.T140T	ZBP1_ENST00000371173.3_Silent_p.T163T|ZBP1_ENST00000395822.3_Silent_p.T88T|ZBP1_ENST00000541799.1_Silent_p.T163T|ZBP1_ENST00000343535.4_Silent_p.T163T			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	163						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GGCGGTAAATCGTCCATGCTT	0.552000													50	128					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167747817	167747817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167747817G>A	ENST00000470487.1	-	10	1873	c.1184C>T	c.(1183-1185)cCt>cTt	p.P395L	GOLIM4_ENST00000309027.4_Missense_Mutation_p.P367L	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	395	Glu-rich.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTTGGCTGAAGGGTACACCTA	0.522000													31	60					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32893986	32893986	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32893986G>A	ENST00000330048.5	-	0	1271					NR_003083.2																						GGCCACATGTGGCCCAGGGCA	0.567000													9	76					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62049186	62049186	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62049186G>A	ENST00000578147.1	-	4	583	c.507C>T	c.(505-507)acC>acT	p.T169T	SCN4A_ENST00000435607.1_Silent_p.T169T			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	169					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GGGACTCAAAGGTGTAGATCC	0.592000													8	23					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184103895	184103895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184103895C>T	ENST00000204604.1	+	15	2126	c.1880C>T	c.(1879-1881)gCc>gTc	p.A627V	EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000545352.1_Missense_Mutation_p.A257V|CHRD_ENST00000348986.3_Missense_Mutation_p.A587V|CHRD_ENST00000450923.1_Missense_Mutation_p.A627V	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	627	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AAAGGCATGGCCTCCCTGATG	0.617000													29	80					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202710505	202710505	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202710505G>T	ENST00000367265.3	-	19	4099	c.2935C>A	c.(2935-2937)Ctc>Atc	p.L979I	KDM5B_ENST00000367264.2_Missense_Mutation_p.L1015I	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	979					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						CTGGCCTTGAGGAGACTCTTG	0.522000													17	47					9.16793e-09	9.19977e-09	1	1	0
NKX2-2	4821	broad.mit.edu	37	20	21492959	21492959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:21492959C>T	ENST00000377142.4	-	2	780	c.424G>A	c.(424-426)Gag>Aag	p.E142K		NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	142					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						CGCTCCAGCTCGTAGGTCTGC	0.677000													8	22					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183655757	183655757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183655757G>A	ENST00000334444.6	-	26	4026	c.3786C>T	c.(3784-3786)ggC>ggT	p.G1262G	ABCC5_ENST00000265586.6_Silent_p.G1219G	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1262	ABC transporter 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GGTCGGCAAGGCCAATATCAC	0.547000													34	75					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188507	140188507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140188507G>A	ENST00000530339.1	+	1	1735	c.1735G>A	c.(1735-1737)Gag>Aag	p.E579K	PCDHA4_ENST00000512229.2_Missense_Mutation_p.E579K|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.E579K|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCAGTGAGCGAGCTGGTGCC	0.662000													19	75					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78717428	78717428	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:78717428G>A	ENST00000436010.2	-	11	2535	c.1538C>T	c.(1537-1539)cCa>cTa	p.P513L	ROBO1_ENST00000495273.1_Missense_Mutation_p.P516L|ROBO1_ENST00000467549.1_Missense_Mutation_p.P516L|ROBO1_ENST00000464233.1_Missense_Mutation_p.P552L			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	552	Ig-like C2-type 5.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AGTAGGTCTTGGAGGCTGAAC	0.388000													39	114					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531154	50531154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50531154C>T	ENST00000374144.3	+	3	852	c.564C>T	c.(562-564)ttC>ttT	p.F188F	C10orf71_ENST00000323868.4_Silent_p.F188F			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	188										endometrium(1)	1						ACTTCTGCTTCGATTCTGCCT	0.547000													10	36					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22927561	22927561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22927561G>A	ENST00000166244.3	+	15	2781	c.2709G>A	c.(2707-2709)agG>agA	p.R903R		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	903						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AGAGTCTCAGGGCCACCGCCA	0.637000													25	45					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23117572	23117572	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23117572G>A	ENST00000219689.7	-	4	914	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	305					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		AAATGCAAAGGAAAGGATCAA	0.383000													19	59					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121061450	121061450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121061450C>T	ENST00000392793.1	+	24	6674	c.6403C>T	c.(6403-6405)Ctt>Ttt	p.L2135F	TECTA_ENST00000264037.2_Missense_Mutation_p.L2135F			O75443	TECTA_HUMAN	tectorin alpha	2135					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix		p.L2135delL(1)	TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGTCTGGACGCTTCTTCTCAT	0.383000													15	32					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183995769	183995769	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183995769C>T	ENST00000402825.3	+	5	889	c.889C>T	c.(889-891)Cta>Tta	p.L297L	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000359140.4_Silent_p.L150L|ECE2_ENST00000404464.3_Silent_p.L179L|ECE2_ENST00000357474.5_Silent_p.L225L	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	297	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCGCTTCTACCTATCTTGCCT	0.557000													28	63					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145109543	145109543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145109543G>A	ENST00000426825.1	-	19	2688	c.2607C>T	c.(2605-2607)ccC>ccT	p.P869P	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	869							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	TGGTGGAGTGGGGGGGCATGG	0.642000													6	39					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238223	104238223	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104238223G>A	ENST00000374851.1	-	4	2299	c.1152C>T	c.(1150-1152)ctC>ctT	p.L384L	RP11-490D19.6_ENST00000431507.1_RNA|TMEM246_ENST00000374847.1_Silent_p.L384L|RP11-490D19.6_ENST00000450109.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374848.3_Silent_p.L384L			Q9BRR3	CI125_HUMAN	transmembrane protein 246	384						integral to membrane											TGTGTTTCACGAGGTTCGGCT	0.542000													33	53					0	0	1	0	0
CHODL	140578	broad.mit.edu	37	21	19638318	19638318	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:19638318C>T	ENST00000338326.3	+	5	1073	c.559C>T	c.(559-561)Caa>Taa	p.Q187*	CHODL_ENST00000299295.2_Missense_Mutation_p.S262L|CHODL_ENST00000400135.1_Nonsense_Mutation_p.Q187*|CHODL_ENST00000400127.1_Missense_Mutation_p.S221L|CHODL_ENST00000400131.1_Nonsense_Mutation_p.Q187*|CHODL_ENST00000400128.1_Missense_Mutation_p.S221L|CHODL_ENST00000543733.1_Missense_Mutation_p.S243L			Q9H9P2	CHODL_HUMAN	chondrolectin	0					muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		CTGTGGATTTCAAAGAGTACC	0.323000													27	62					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183053786	183053786	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:183053786C>T	ENST00000435564.1	-	11	1375	c.1173_splice	c.e11-1	p.G392_splice	PDE1A_ENST00000536095.1_Splice_Site_p.G288_splice|PDE1A_ENST00000409365.1_Splice_Site_p.G376_splice|PDE1A_ENST00000456212.1_Splice_Site_p.G392_splice|PDE1A_ENST00000410103.1_Splice_Site_p.G392_splice|PDE1A_ENST00000358139.2_Splice_Site_p.G392_splice|PDE1A_ENST00000351439.5_Splice_Site_p.G376_splice|PDE1A_ENST00000331935.6_Splice_Site_p.G392_splice|PDE1A_ENST00000346717.4_Splice_Site_p.G358_splice	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	392	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.G392E(2)|p.G392V(2)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTCTTTATCTCCCTGGAGAAA	0.393000													41	101					0	0	1	0	0
SERPINA11	256394	broad.mit.edu	37	14	94914801	94914801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94914801C>T	ENST00000334708.3	-	2	375	c.311G>A	c.(310-312)gGa>gAa	p.G104E	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	104					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		GAGGTTGAATCCCAGGCCCTC	0.587000													41	90					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1240646	1240646	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1240646G>A	ENST00000324642.3	+	7	969	c.845_splice	c.e7-1	p.R282_splice	SLC6A18_ENST00000296821.4_Splice_Site_p.R277_splice	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	282					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.R282R(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TTGTGCCCAGGAATGACTGCC	0.587000													21	36					0	0	1	0	0
NXT1	29107	broad.mit.edu	37	20	23334836	23334836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23334836C>T	ENST00000254998.2	+	2	545	c.158C>T	c.(157-159)tCa>tTa	p.S53L		NM_013248.2	NP_037380.1	Q9UKK6	NXT1_HUMAN	NTF2-like export factor 1	53	NTF2.					cytoplasm|nuclear pore				NS(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	6	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					AATGCTGTTTCAGGACAAGAA	0.507000													29	55					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871921	51871921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51871921G>A	ENST00000371497.5	+	2	2811	c.1924G>A	c.(1924-1926)Gaa>Aaa	p.E642K	TSHZ2_ENST00000603338.2_Missense_Mutation_p.E639K|TSHZ2_ENST00000329613.6_Missense_Mutation_p.E639K	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	642					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AACACCTCCAGAAGCCAAAAA	0.557000													31	68					0	0	1	0	0
WDR75	84128	broad.mit.edu	37	2	190327291	190327291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:190327291C>T	ENST00000314761.4	+	9	920	c.860C>T	c.(859-861)cCg>cTg	p.P287L		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	287						nucleolus		p.P287Q(2)		breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			GAGTTTCTCCCGCGTTTAGGA	0.428000													50	115					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73464832	73464832	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73464832G>A	ENST00000224721.6	+	24	2918	c.2913G>A	c.(2911-2913)gtG>gtA	p.V971V	CDH23_ENST00000299366.7_Silent_p.V1011V	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	966	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						TGCGGGTGGTGGCCAGTGATG	0.662000													27	40					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57430866	57430866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57430866G>A	ENST00000442789.2	-	21	2352	c.2065C>T	c.(2065-2067)Ctc>Ttc	p.L689F	MYO1A_ENST00000544473.1_Missense_Mutation_p.L527F|MYO1A_ENST00000300119.3_Missense_Mutation_p.L689F	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	689					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TGTTCTTCGAGGTAGAAAAGC	0.572000													21	89					0	0	1	0	0
SH2D7	646892	broad.mit.edu	37	15	78393813	78393813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78393813C>T	ENST00000328828.5	+	5	1218	c.1218C>T	c.(1216-1218)atC>atT	p.I406I	SH2D7_ENST00000409568.2_Silent_p.I270I	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	406										endometrium(2)|kidney(2)|lung(3)	7						ACAAGAGGATCTCAGGGACCC	0.592000													6	24					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104641701	104641701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104641701G>A	ENST00000315264.7	+	11	2537	c.2159G>A	c.(2158-2160)gGa>gAa	p.G720E	KIF26A_ENST00000423312.2_Missense_Mutation_p.G859E			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	859					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GGTCCCTCAGGAGGTCCAGGT	0.711000													9	18					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65623883	65623883	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65623883C>T	ENST00000327987.4	-	8	1514	c.1263G>A	c.(1261-1263)gaG>gaA	p.E421E	IGDCC3_ENST00000559231.1_5'UTR	NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	421										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CGGGGAGCCCCTCAGCCCACA	0.617000													9	29					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196709907	196709907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196709907C>T	ENST00000367429.4	+	18	3181	c.2941C>T	c.(2941-2943)Cct>Tct	p.P981S		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	981	Sushi 16.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						ATGGTCTCACCCTCCATCATG	0.343000													18	66					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186944231	186944231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186944231C>T	ENST00000337774.5	-	12	1908	c.1519G>A	c.(1519-1521)Gac>Aac	p.D507N		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	507	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CTGAGCAAGTCTGAATCACGT	0.572000													3	12					0	0	1	0	0
PNP	4860	broad.mit.edu	37	14	20943237	20943237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20943237C>T	ENST00000361505.5	+	5	624	c.478C>T	c.(478-480)Cct>Tct	p.P160S	RP11-203M5.8_ENST00000554678.1_lincRNA	NM_000270.3	NP_000261.2	P00491	PNPH_HUMAN	purine nucleoside phosphorylase	160					immune response|inosine catabolic process|interleukin-2 secretion|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide riboside catabolic process|positive regulation of alpha-beta T cell differentiation|positive regulation of T cell proliferation|purine base metabolic process|purine nucleotide catabolic process|purine-containing compound salvage|response to drug|urate biosynthetic process	cytoskeleton|cytosol	drug binding|nucleoside binding|phosphate binding|purine base binding|purine-nucleoside phosphorylase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|stomach(2)	10					Aciclovir(DB00787)|Cladribine(DB00242)|Mercaptopurine(DB01033)	AGATCGTTTCCCTGCCATGTC	0.473000													18	36					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062169	9062169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9062169C>T	ENST00000397910.4	-	3	25480	c.25277G>A	c.(25276-25278)aGg>aAg	p.R8426K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8428	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGCTGATCCTCTCAGAGCT	0.507000													39	70					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54142292	54142292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:54142292C>T	ENST00000265572.3	-	4	1005	c.708G>A	c.(706-708)gtG>gtA	p.V236V	RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000524278.1_Silent_p.V147V|OPRK1_ENST00000520287.1_Silent_p.V236V	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	236					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GGACAGGGATCACGAAGGCAA	0.532000													18	51					0	0	1	0	0
EFCAB11	90141	broad.mit.edu	37	14	90420996	90420996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90420996G>A	ENST00000316738.7	-	1	37	c.9C>T	c.(7-9)ttC>ttT	p.F3F	EFCAB11_ENST00000267544.9_5'UTR|EFCAB11_ENST00000538485.2_Silent_p.F3F|RP11-33N16.3_ENST00000555070.1_RNA|EFCAB11_ENST00000556609.1_Intron	NM_145231.2	NP_660274.1	Q9BUY7	EFC11_HUMAN	EF-hand calcium binding domain 11	3							calcium ion binding			large_intestine(1)|lung(1)	2						TGGCCTCGGAGAAGAACATCG	0.652000													3	21					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995647	19995647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:19995647G>A	ENST00000391403.2	-	1	2231	c.2128C>T	c.(2128-2130)Cca>Tca	p.P710S		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	710	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GGTGGACCTGGGACATCCCTT	0.522000													33	95					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150868515	150868515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150868515C>T	ENST00000370353.3	+	3	445	c.55C>T	c.(55-57)Cgt>Tgt	p.R19C	PRRG3_ENST00000370354.1_Missense_Mutation_p.R27C|PRRG3_ENST00000538575.1_Missense_Mutation_p.R19C			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	19						extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					ACGATTCCCTCGTGCCAATGA	0.582000													27	17					0	0	1	0	0
SOHLH1	402381	broad.mit.edu	37	9	138587048	138587048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138587048G>A	ENST00000298466.5	-	6	783	c.723C>T	c.(721-723)ccC>ccT	p.P241P	SOHLH1_ENST00000425225.1_Silent_p.P241P	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1	241					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		GCCAGGACAGGGGTGGCCTCA	0.692000													4	13					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3547941	3547941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3547941C>T	ENST00000355415.2	-	4	911	c.742G>A	c.(742-744)Gag>Aag	p.E248K	MFSD12_ENST00000389395.3_Missense_Mutation_p.E248K|MFSD12_ENST00000591878.1_5'UTR|MFSD12_ENST00000398558.4_Missense_Mutation_p.E248K|AC005786.7_ENST00000589360.1_RNA	NM_174983.3	NP_778148.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	248					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						CCTGGCTCCTCCGCATGCGGC	0.701000													7	17					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24930354	24930354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:24930354C>T	ENST00000405141.1	+	14	2726	c.2015C>T	c.(2014-2016)tCa>tTa	p.S672L	NCOA1_ENST00000538539.1_Missense_Mutation_p.S672L|NCOA1_ENST00000288599.5_Missense_Mutation_p.S672L|NCOA1_ENST00000407230.1_Missense_Mutation_p.S521L|NCOA1_ENST00000406961.1_Missense_Mutation_p.S672L|NCOA1_ENST00000395856.3_Missense_Mutation_p.S672L|NCOA1_ENST00000348332.3_Missense_Mutation_p.S672L			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	672	Ser-rich.								PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTAACTCTTCAGGAGGTTCT	0.488000			T	PAX3	alveolar rhadomyosarcoma								31	89					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150768843	150768843	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150768843C>T	ENST00000485713.1	+	15	3299	c.2259C>T	c.(2257-2259)gtC>gtT	p.V753V	SLC4A2_ENST00000413384.2_Silent_p.V753V|SLC4A2_ENST00000461735.1_Silent_p.V739V|SLC4A2_ENST00000310317.5_Silent_p.V671V|SLC4A2_ENST00000392826.2_Silent_p.V744V	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	753	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGCGTGGTCTTCTGCCTGC	0.622000													41	106					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62782792	62782792	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62782792G>A	ENST00000582986.1	-	0	2257					NR_024386.1																						CATGCTGGGAGGCAAATTCAA	0.542000													5	20					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013235	73013235	+	Silent	SNP	C	C	T	rs145038184	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73013235C>T	ENST00000308744.6	+	4	1373	c.1275C>T	c.(1273-1275)ttC>ttT	p.F425F	NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000358749.3_Silent_p.F323F|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000395999.1_Silent_p.F326F	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	425					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GGCTGGCATTCGGCAACAGCA	0.463000													43	100					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187542889	187542889	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187542889G>A	ENST00000441802.2	-	10	5060	c.4851C>T	c.(4849-4851)ggC>ggT	p.G1617G		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1617	Cadherin 14.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTTTAATAGAGCCCAAGACAG	0.368000										HNSCC(5;0.00058)			6	16					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50345793	50345793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50345793G>A	ENST00000376020.2	-	7	3807	c.3782C>T	c.(3781-3783)tCg>tTg	p.S1261L	SHROOM4_ENST00000460112.3_Missense_Mutation_p.S1145L|SHROOM4_ENST00000289292.7_Missense_Mutation_p.S1261L	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1261	ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding	p.S1261L(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					TGAAGGAGGCGAAAAGTGCTG	0.458000													17	13					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588639	20588639	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20588639C>T	ENST00000428453.1	-	0	4111																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GTTCATTCTTCTTATAAATAA	0.413000													21	56					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784909	30784909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30784909G>A	ENST00000246229.4	-	3	1101	c.837C>T	c.(835-837)gcC>gcT	p.A279A		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	279						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CGTCCCGAGAGGCCATGCACA	0.592000													19	51					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11364849	11364849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:11364849G>A	ENST00000304623.8	-	8	1520	c.1331C>T	c.(1330-1332)cCt>cTt	p.P444L	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.P107L|CTNND2_ENST00000511377.1_Missense_Mutation_p.P353L|CTNND2_ENST00000458100.2_Missense_Mutation_p.P11L|CTNND2_ENST00000359640.2_Missense_Mutation_p.P444L	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	444					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGGCGGCAGAGGGTCCCCCTG	0.642000													14	26					0	0	1	0	0
TBX3	6926	broad.mit.edu	37	12	115109849	115109849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:115109849G>A	ENST00000349155.2	-	7	2932	c.1969C>T	c.(1969-1971)Ctg>Ttg	p.L657L	TBX3_ENST00000257566.3_Silent_p.L677L	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	677	Transcription repression.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CTGGCGGCCAGGGCGGCGACT	0.716000													4	5					0	0	1	0	0
TMEM255B	348013	broad.mit.edu	37	13	114498180	114498180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:114498180C>T	ENST00000375353.3	+	4	339	c.312C>T	c.(310-312)atC>atT	p.I104I		NM_182614.2	NP_872420.1			transmembrane protein 255B																		GCTGCGCCATCGTGGACGGCG	0.527000													10	37					0	0	1	0	0
MVP	9961	broad.mit.edu	37	16	29856018	29856018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29856018C>T	ENST00000357402.5	+	11	1977	c.1839C>T	c.(1837-1839)ggC>ggT	p.G613G	MVP_ENST00000395353.1_Silent_p.G613G	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	613					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						AAGCGAAGGGCCCCGATGGCA	0.627000													52	122					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43680255	43680255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43680255C>T	ENST00000404580.1	-	3	564	c.476G>A	c.(475-477)aGg>aAg	p.R159K	PSG5_ENST00000599812.1_Missense_Mutation_p.R252K|PSG5_ENST00000407356.1_Missense_Mutation_p.R159K|PSG5_ENST00000342951.6_Missense_Mutation_p.R159K|PSG5_ENST00000366175.3_Missense_Mutation_p.R159K|PSG5_ENST00000407568.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	159	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				CTTATTCTCCCTGGGTTTTGA	0.493000													112	261					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10696209	10696209	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:10696209G>A	ENST00000302079.6	-	43	6713	c.6714C>T	c.(6712-6714)ctC>ctT	p.L2238L	PIEZO2_ENST00000538948.1_Silent_p.L195L|PIEZO2_ENST00000285141.4_Silent_p.L93L|PIEZO2_ENST00000580640.1_Silent_p.L2263L|PIEZO2_ENST00000503781.3_Silent_p.L2238L			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2238						integral to membrane	ion channel activity										CAAACTGAATGAGGACCATCA	0.512000													20	53					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38607954	38607954	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38607954G>A	ENST00000413689.1	-	21	3979	c.3786C>T	c.(3784-3786)ggC>ggT	p.G1262G	SCN5A_ENST00000423572.2_Silent_p.G1261G|SCN5A_ENST00000425664.1_Silent_p.G1262G|SCN5A_ENST00000333535.4_Silent_p.G1262G|SCN5A_ENST00000451551.2_Silent_p.G1208G|SCN5A_ENST00000455624.2_Silent_p.G1261G|SCN5A_ENST00000449557.2_Silent_p.G1208G|SCN5A_ENST00000450102.2_Silent_p.G1208G|SCN5A_ENST00000443581.1_Silent_p.G1261G|SCN5A_ENST00000414099.2_Silent_p.G1262G	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1262			G -> S (in BRS1).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACTTCTTGAAGCCGTAGGCCA	0.532000													14	138					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75902057	75902057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:75902057C>T	ENST00000322507.8	-	4	514	c.205G>A	c.(205-207)Gaa>Aaa	p.E69K	COL12A1_ENST00000483888.2_Missense_Mutation_p.E69K|COL12A1_ENST00000416123.2_Missense_Mutation_p.E69K|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	69	Fibronectin type-III 1.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AGGGTAAATTCTTTAGTAGGC	0.328000													8	56					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8188819	8188819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8188819C>T	ENST00000600128.1	-	23	3219	c.2805G>A	c.(2803-2805)cgG>cgA	p.R935R	FBN3_ENST00000601739.1_Silent_p.R935R|FBN3_ENST00000270509.2_Silent_p.R935R			Q75N90	FBN3_HUMAN	fibrillin 3	935	TB 5.		R -> L.			proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AGACGTCCATCCGGTACTTGC	0.647000													13	33					0	0	1	0	0
SNX24	28966	broad.mit.edu	37	5	122343382	122343382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:122343382C>T	ENST00000261369.4	+	7	633	c.448C>T	c.(448-450)Cca>Tca	p.P150S	SNX24_ENST00000395451.4_Missense_Mutation_p.P183S|SNX24_ENST00000513881.1_3'UTR	NM_014035.2	NP_054754.1	Q9Y343	SNX24_HUMAN	sorting nexin 24	150					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			lung(5)	5		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		ttCAGATTTTCCAAATGTGGT	0.333000													39	79					0	0	1	0	0
MB	4151	broad.mit.edu	37	22	36007060	36007060	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36007060C>T	ENST00000397326.2	-	2	387	c.189G>A	c.(187-189)aaG>aaA	p.K63K	MB_ENST00000359787.1_Silent_p.K63K|MB_ENST00000401702.1_Silent_p.K8K|MB_ENST00000406324.1_Silent_p.K63K|MB_ENST00000397328.1_Silent_p.K63K	NM_005368.2	NP_005359.1	P02144	MYG_HUMAN	myoglobin	63							heme binding|oxygen transporter activity			lung(1)	1						CACCATGCTTCTTTAAGTCCT	0.547000													18	91					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768050	57768050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57768050C>T	ENST00000371030.2	+	1	1976	c.1976C>T	c.(1975-1977)cCt>cTt	p.P659L		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	659						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CTGGGCTTTCCTCTGCAGAAA	0.582000													20	63					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5041989	5041989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:5041989C>T	ENST00000251170.7	+	6	805	c.625C>T	c.(625-627)Cgt>Tgt	p.R209C		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	209						integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						CCACGGGCCCCGTAGCACCCT	0.697000													5	6					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3417829	3417829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3417829G>A	ENST00000356575.4	-	19	2584	c.2358C>T	c.(2356-2358)tgC>tgT	p.C786C	MEGF6_ENST00000294599.4_Silent_p.C681C	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	786	EGF-like 13.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GGCATGCTGGGCAGATCTCCT	0.677000													10	17					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469290	72469290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:72469290C>T	ENST00000296776.5	+	1	269	c.220C>T	c.(220-222)Ctt>Ttt	p.L74F	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	74						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		GACCCAGCTCCTTGGGCCCGT	0.512000													11	105					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20135715	20135715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:20135715C>T	ENST00000395530.2	+	5	2313	c.2105C>T	c.(2104-2106)cCt>cTt	p.P702L	SPECC1_ENST00000395525.3_Missense_Mutation_p.P702L|SPECC1_ENST00000536879.1_Missense_Mutation_p.P123L|AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000261503.5_Missense_Mutation_p.P783L|SPECC1_ENST00000395529.3_Missense_Mutation_p.P783L|SPECC1_ENST00000584527.1_Missense_Mutation_p.P201L|SPECC1_ENST00000395522.2_Missense_Mutation_p.P702L|SPECC1_ENST00000395527.4_Missense_Mutation_p.P783L|SPECC1_ENST00000472876.1_3'UTR	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	783						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		AGAGCCGCCCCTCCGTGAGTC	0.612000													5	7					0	0	1	0	0
PNMA2	10687	broad.mit.edu	37	8	26365908	26365908	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:26365908G>A	ENST00000522362.2	-	3	1258	c.364C>T	c.(364-366)Cga>Tga	p.R122*		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	122					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		cccagggctcgaaacataccc	0.527000													25	67					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540727	55540727	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55540727C>T	ENST00000220676.1	+	4	4433	c.4285C>T	c.(4285-4287)Cag>Tag	p.Q1429*		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1429					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGAAGTTTCAGGATGAAAA	0.368000													24	59					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219553448	219553448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219553448C>T	ENST00000295709.3	+	12	1688	c.1409C>T	c.(1408-1410)tCc>tTc	p.S470F	STK36_ENST00000392106.2_Missense_Mutation_p.S470F|STK36_ENST00000392105.3_Missense_Mutation_p.S470F|STK36_ENST00000440309.1_Missense_Mutation_p.S470F	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	470					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GAGGGTGCTTCCCACATCCTG	0.517000													88	204					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47560332	47560332	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47560332G>A	ENST00000334194.3	+	7	870	c.867G>A	c.(865-867)ttG>ttA	p.L289L		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	289						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						ACATACTTTTGAGTGCCAAAG	0.398000													17	51					0	0	1	0	0
DDX58	23586	broad.mit.edu	37	9	32500834	32500834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32500834G>A	ENST00000379883.2	-	2	367	c.210C>T	c.(208-210)ttC>ttT	p.F70F	DDX58_ENST00000379882.1_Intron|DDX58_ENST00000379868.1_5'UTR|DDX58_ENST00000542096.1_5'UTR|DDX58_ENST00000545044.1_5'UTR	NM_014314.3	NP_055129.2	O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	70	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		AAAAGCCACGGAACCAGCCTT	0.443000													43	74					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72295967	72295967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72295967G>A	ENST00000579490.1	+	6	1141	c.1006G>A	c.(1006-1008)Gag>Aag	p.E336K	DNAI2_ENST00000582036.1_Missense_Mutation_p.E279K|DNAI2_ENST00000446837.2_Missense_Mutation_p.E279K|DNAI2_ENST00000307504.5_Missense_Mutation_p.E136K|DNAI2_ENST00000311014.6_Missense_Mutation_p.E279K			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	279					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GACGGGCACCGAGTGCTTCTC	0.617000									Kartagener syndrome				15	40					0	0	1	0	0
CSH1	1442	broad.mit.edu	37	17	61972439	61972439	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61972439G>A	ENST00000316193.8	-	5	738	c.597C>T	c.(595-597)gtC>gtT	p.V199V	CSH1_ENST00000453363.3_Silent_p.V104V|CSH1_ENST00000329882.8_3'UTR	NM_001317.5	NP_001308.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 (placental lactogen)	199					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			central_nervous_system(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						GGAATGTCTCGACCTTGTCCA	0.572000									Russell-Silver syndrome				16	164					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198651	20198651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20198651C>T	ENST00000400331.5	-	5	1641	c.1333G>A	c.(1333-1335)Gaa>Aaa	p.E445K	MACC1_ENST00000332878.4_Missense_Mutation_p.E445K|MACC1_ENST00000589011.1_Missense_Mutation_p.E445K	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	445					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						GTCTTTACTTCAAAATCAGGA	0.353000													16	69					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140991028	140991028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140991028C>T	ENST00000277549.5	+	37	5338	c.2769C>T	c.(2767-2769)ttC>ttT	p.F923F	CACNA1B_ENST00000371357.1_Silent_p.F1728F|CACNA1B_ENST00000371363.1_Silent_p.F1727F|CACNA1B_ENST00000277551.2_Silent_p.F1729F|CACNA1B_ENST00000371365.2_Silent_p.F93F|CACNA1B_ENST00000371355.4_Silent_p.F1730F|CACNA1B_ENST00000371372.1_Silent_p.F1729F			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1729					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGGATGAGTTCATCCGGGTCT	0.557000													18	47					0	0	1	0	0
KY	339855	broad.mit.edu	37	3	134369698	134369698	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134369698C>T	ENST00000508956.1	-	1	162	c.105G>A	c.(103-105)gcG>gcA	p.A35A	KY_ENST00000423778.2_Silent_p.A35A|KY_ENST00000503669.1_Silent_p.A35A			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	35						cytoskeleton|Z disc	peptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						AGCTCGGGTTCGCCTGCTGGT	0.672000													9	20					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31139024	31139024	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:31139024G>A	ENST00000538351.1	-	7	917	c.163C>T	c.(163-165)Cag>Tag	p.Q55*	ZNF438_ENST00000331737.6_Nonsense_Mutation_p.Q94*|ZNF438_ENST00000444692.2_Nonsense_Mutation_p.Q94*|ZNF438_ENST00000442986.1_Nonsense_Mutation_p.Q104*|ZNF438_ENST00000452305.1_Nonsense_Mutation_p.Q94*|ZNF438_ENST00000361310.3_Nonsense_Mutation_p.Q104*|ZNF438_ENST00000375311.1_Intron|ZNF438_ENST00000413025.1_Nonsense_Mutation_p.Q104*|ZNF438_ENST00000436087.2_Nonsense_Mutation_p.Q104*	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TGAATTGGCTGAGCTGAGGCA	0.488000													32	127					0	0	1	0	0
HDHD1	8226	broad.mit.edu	37	X	7023738	7023738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:7023738G>A	ENST00000381077.5	-	2	279	c.203C>T	c.(202-204)cCg>cTg	p.P68L	HDHD1_ENST00000412827.2_Intron|HDHD1_ENST00000498474.2_5'UTR|HDHD1_ENST00000424830.2_Missense_Mutation_p.P91L|HDHD1_ENST00000540122.1_Missense_Mutation_p.P68L	NM_001178136.1|NM_012080.4	NP_001171607.1|NP_036212.3	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain containing 1	68					nucleotide metabolic process		metal ion binding|phosphatase activity			breast(2)|large_intestine(1)|lung(3)	6						TTTGGACATCGGGAGCTGCAA	0.502000													4	13					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57437748	57437748	+	Nonsense_Mutation	SNP	G	G	A	rs138607619		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57437748G>A	ENST00000442789.2	-	11	1071	c.784C>T	c.(784-786)Cga>Tga	p.R262*	MYO1A_ENST00000544473.1_Nonsense_Mutation_p.R100*|MYO1A_ENST00000300119.3_Nonsense_Mutation_p.R262*	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	262	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						AGCACTTGTCGAATCTCCTCC	0.517000													29	66					0	0	1	0	0
SAMD3	154075	broad.mit.edu	37	6	130465869	130465869	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:130465869C>T	ENST00000368134.2	-	14	1967	c.1359G>A	c.(1357-1359)agG>agA	p.R453R	SAMD3_ENST00000439090.2_Silent_p.R453R|SAMD3_ENST00000437477.2_Silent_p.R453R|SAMD3_ENST00000457563.2_Silent_p.R477R	NM_001258275.1	NP_001245204.1	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	453										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TGAGCCTCTCCCTTTCTAAAT	0.443000													24	29					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21120147	21120147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21120147C>T	ENST00000377122.4	-	16	2045	c.1649G>A	c.(1648-1650)aGg>aAg	p.R550K	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	550					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TTCAGATGTCCTCTTGGCTCG	0.388000													14	74					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192554	211192554	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:211192554C>T	ENST00000367007.4	-	6	772	c.603G>A	c.(601-603)gaG>gaA	p.E201E	KCNH1_ENST00000271751.4_Silent_p.E201E	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	201					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TCTTTGGTGCCTCTTGCTTGT	0.433000													36	72					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	527691	527691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:527691C>T	ENST00000453061.2	+	12	2762	c.2656C>T	c.(2656-2658)Ctg>Ttg	p.L886L	PIGG_ENST00000504346.1_Silent_p.L797L|PIGG_ENST00000310340.5_Silent_p.L878L|PIGG_ENST00000383028.4_Silent_p.L753L|PIGG_ENST00000296306.7_3'UTR	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	886					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						AGCCGTGCTCCTGACAGCGTT	0.592000													28	49					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250700	140250700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140250700G>A	ENST00000398640.2	+	1	2012	c.2012G>A	c.(2011-2013)aGc>aAc	p.S671N	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGGTGGAGAGCGGACAGGCG	0.662000													16	68					0	0	1	0	0
DENND5A	23258	broad.mit.edu	37	11	9199886	9199886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:9199886G>A	ENST00000328194.3	-	8	2019	c.1699C>T	c.(1699-1701)Ccc>Tcc	p.P567S	DENND5A_ENST00000530044.1_Missense_Mutation_p.P567S	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	567	dDENN.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGCAGGTAGGGCTCAGGCTGA	0.453000													11	27					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72511377	72511377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72511377C>T	ENST00000373208.1	+	17	2580	c.2580C>T	c.(2578-2580)gcC>gcT	p.A860A	ADAMTS14_ENST00000373207.1_Silent_p.A857A	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	857	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						AGAGCTGGGCCCCCTGCAGCA	0.617000													19	48					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34109088	34109088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34109088C>T	ENST00000389232.4	+	75	10598	c.10528C>T	c.(10528-10530)Cat>Tat	p.H3510Y	RYR3_ENST00000415757.3_Missense_Mutation_p.H3505Y	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3510					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTCTTCCTCCATGGCTATCA	0.463000													7	17					0	0	1	0	0
IL17RE	132014	broad.mit.edu	37	3	9944701	9944701	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9944701C>T	ENST00000454190.2	+	1	170	c.85C>T	c.(85-87)Cgc>Tgc	p.R29C	IL17RE_ENST00000383814.3_Missense_Mutation_p.R29C|IL17RE_ENST00000421412.1_Missense_Mutation_p.R62C|IL17RE_ENST00000295980.3_Missense_Mutation_p.R29C	NM_001193380.1	NP_001180309.1	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E	29						cytoplasm|extracellular region|integral to membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(11)|skin(1)	21				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GATTGGCTTTCGCCACCTGCC	0.612000													36	75					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077764	9077764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9077764G>A	ENST00000397910.4	-	3	9885	c.9682C>T	c.(9682-9684)Cct>Tct	p.P3228S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3229	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTTCCAAGGAGAATTTCTC	0.522000													41	139					0	0	1	0	0
SLC35E3	55508	broad.mit.edu	37	12	69145889	69145889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:69145889C>T	ENST00000398004.2	+	3	863	c.591C>T	c.(589-591)gcC>gcT	p.A197A		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	197						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			TGTCATCTGCCATGTTGCTGG	0.443000													72	179					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49688113	49688113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49688113C>T	ENST00000296452.4	+	4	1701	c.1587C>T	c.(1585-1587)acC>acT	p.T529T		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	529					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GAGAGCCGACCCCCCTGCCGC	0.627000													72	161					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713515	70713515	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70713515G>A	ENST00000530196.1	-	0	1003					NR_003951.1																						TTGTAGCTGGGAACGACTGAT	0.373000													42	89					0	0	1	0	0
OR1J1	347168	broad.mit.edu	37	9	125240122	125240122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125240122G>A	ENST00000259357.2	-	1	113	c.84C>T	c.(82-84)ttC>ttT	p.F28F		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						GGAACAGGGCGAAGAACACGG	0.587000													63	124					0	0	1	0	0
ASS1	445	broad.mit.edu	37	9	133333958	133333958	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133333958C>T	ENST00000372394.1	+	5	826	c.345C>T	c.(343-345)tcC>tcT	p.S115S	ASS1_ENST00000372393.3_Silent_p.S115S|ASS1_ENST00000352480.5_Silent_p.S115S			P00966	ASSY_HUMAN	argininosuccinate synthase 1	115					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	17				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	AGTATGTGTCCCACGGCGCCA	0.647000													6	22					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128643385	128643385	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:128643385C>T	ENST00000368227.3	-	3	660	c.294G>A	c.(292-294)atG>atA	p.M98I	PTPRK_ENST00000525459.1_Missense_Mutation_p.M98I|PTPRK_ENST00000368215.3_Missense_Mutation_p.M98I|PTPRK_ENST00000368207.3_Missense_Mutation_p.M98I|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368210.3_Missense_Mutation_p.M98I|PTPRK_ENST00000368213.5_Missense_Mutation_p.M98I|PTPRK_ENST00000368226.4_Missense_Mutation_p.M98I|PTPRK_ENST00000532331.1_Missense_Mutation_p.M98I			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	98	MAM.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CGTTCTCCTTCATTGTAGGCA	0.388000													75	73					0	0	1	0	0
B4GALT2	8704	broad.mit.edu	37	1	44447081	44447081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44447081C>T	ENST00000434555.2	+	2	377	c.95C>T	c.(94-96)cCa>cTa	p.P32L	B4GALT2_ENST00000372324.1_Silent_p.P83P|B4GALT2_ENST00000356836.6_Silent_p.P83P|B4GALT2_ENST00000309519.7_Silent_p.P112P			O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2	89					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	CTGAGGTCCCCAGTGCCCTGC	0.697000													12	34					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403730	47403730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47403730C>T	ENST00000310638.4	-	2	306	c.275G>A	c.(274-276)gGa>gAa	p.G92E	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Missense_Mutation_p.G92E|CYP4A11_ENST00000371905.1_Missense_Mutation_p.G92E|CYP4A11_ENST00000457840.2_5'UTR	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	92					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	AACTTTGCCTCCCCATAGCCA	0.512000													34	107					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43749110	43749110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43749110G>A	ENST00000263801.3	-	12	1933	c.1681C>T	c.(1681-1683)Cct>Tct	p.P561S	TP53BP1_ENST00000450115.2_Missense_Mutation_p.P566S|TP53BP1_ENST00000382039.3_Missense_Mutation_p.P566S|TP53BP1_ENST00000382044.4_Missense_Mutation_p.P566S	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	561					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TTTTCAGCAGGAACAAATTTA	0.413000								Other conserved DNA damage response genes					8	103					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33412082	33412082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33412082G>A	ENST00000404816.2	+	6	1714	c.1361G>A	c.(1360-1362)gGg>gAg	p.G454E	LTBP1_ENST00000404525.1_Missense_Mutation_p.G128E|LTBP1_ENST00000402934.1_Missense_Mutation_p.G128E|LTBP1_ENST00000390003.4_Missense_Mutation_p.G128E|LTBP1_ENST00000418533.2_Missense_Mutation_p.G128E|LTBP1_ENST00000407925.1_Missense_Mutation_p.G128E|LTBP1_ENST00000354476.3_Missense_Mutation_p.G454E			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	454					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGGCGTTGGGGACGCATGTC	0.507000													15	52					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155491738	155491738	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155491738A>G	ENST00000302068.4	+	8	1475	c.1412A>G	c.(1411-1413)aAg>aGg	p.K471R	FGB_ENST00000502545.1_3'UTR|FGB_ENST00000509493.1_Missense_Mutation_p.K252R	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	471	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	ATGAATTGGAAGGGGTCATGG	0.473000													15	52					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247463	164247463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164247463G>A	ENST00000296533.2	-	2	775	c.244C>T	c.(244-246)Ctt>Ttt	p.L82F	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	82					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAGAAGGAAAGGTTCACAATC	0.423000													22	67					0	0	1	0	0
OR2T8	343172	broad.mit.edu	37	1	248084466	248084466	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248084466G>A	ENST00000319968.4	+	1	147	c.147G>A	c.(145-147)tgG>tgA	p.W49*		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	49			W -> R (in dbSNP:rs11204564).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGATTCACTGGGACCACCGGC	0.527000													23	98					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66914658	66914658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66914658C>T	ENST00000586539.1	-	15	2006	c.1818G>A	c.(1816-1818)atG>atA	p.M606I	ABCA8_ENST00000430352.2_Missense_Mutation_p.M606I|ABCA8_ENST00000269080.2_Intron			O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	597	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GAATATTTTTCATTTCCAATT	0.338000													8	5					0	0	1	0	0
NELFE	7936	broad.mit.edu	37	6	31921902	31921902	+	Silent	SNP	G	G	A	rs141063076		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31921902G>A	ENST00000375429.3	-	9	1123	c.897C>T	c.(895-897)ttC>ttT	p.F299F	NELFE_ENST00000444811.2_Silent_p.F269F|NELFE_ENST00000375425.5_Silent_p.F306F	NM_002904.5	NP_002895.3			negative elongation factor complex member E																		CATAGGTGACGAAGGCACAGC	0.527000													11	30					0	0	1	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37962533	37962533	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37962533G>A	ENST00000249014.4	+	2	597	c.177G>A	c.(175-177)ggG>ggA	p.G59G		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	59					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					ATGTCTTCGGGGACACGTCCT	0.652000													8	19					0	0	1	0	0
FATE1	89885	broad.mit.edu	37	X	150891177	150891177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150891177C>T	ENST00000370350.3	+	5	583	c.498C>T	c.(496-498)atC>atT	p.I166I		NM_033085.2	NP_149076.1	Q969F0	FATE1_HUMAN	fetal and adult testis expressed 1	166						endoplasmic reticulum|integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(6)|ovary(1)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTGATCATCGCCGTGCTGG	0.652000													28	19					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69324005	69324005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:69324005C>T	ENST00000260364.5	+	5	720	c.419C>T	c.(418-420)gCc>gTc	p.A140V	NOX5_ENST00000448182.3_Missense_Mutation_p.A112V|NOX5_ENST00000530406.2_Missense_Mutation_p.A130V|NOX5_ENST00000455873.3_Missense_Mutation_p.A123V|NOX5_ENST00000388866.3_Missense_Mutation_p.A158V			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	158	EF-hand 3; atypical; contains an insert of 28 residues.|N-terminal regulatory region; interacts with the C-terminal catalytic region in a calcium-dependent manner.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CGCGAGAGCGCCATCTCGCTG	0.672000													7	27					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56387942	56387942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56387942G>A	ENST00000355701.3	-	20	4500	c.3630C>T	c.(3628-3630)gcC>gcT	p.A1210A	BZRAP1_ENST00000268893.6_Silent_p.A1150A|BZRAP1_ENST00000343736.4_Silent_p.A1210A	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1210						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCGCCTGCTGGGCCCGTGCTC	0.672000													21	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179591878	179591878	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179591878G>A	ENST00000589042.1	-	69	20438	c.20214C>T	c.(20212-20214)ttC>ttT	p.F6738F	TTN_ENST00000342992.6_Silent_p.F5494F|TTN_ENST00000591111.1_Silent_p.F6421F|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6421	Ig-like 49.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCACAAATGAAATCTCCAC	0.418000													27	99					0	0	1	0	0
ZNF382	84911	broad.mit.edu	37	19	37100898	37100898	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37100898C>T	ENST00000435416.1	+	1	1577	c.82C>T	c.(82-84)Cag>Tag	p.Q28*	ZNF382_ENST00000292928.2_Nonsense_Mutation_p.Q28*|ZNF382_ENST00000423582.1_Intron|ZNF382_ENST00000439428.1_Nonsense_Mutation_p.Q27*			Q96SR6	ZN382_HUMAN	zinc finger protein 382	28	KRAB.|Mediates interaction with TRIM28 (By similarity).|Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGACCCTGCTCAGAAGGCGCT	0.478000													40	82					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107019951	107019951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:107019951G>A	ENST00000369063.3	-	9	1576	c.1111C>T	c.(1111-1113)Cct>Tct	p.P371S	RTN4IP1_ENST00000498091.1_5'UTR|RTN4IP1_ENST00000539449.1_3'UTR	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	371						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		TTAGAAAAAGGAAAGGTTTGT	0.383000													25	46					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144869848	144869848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:144869848C>T	ENST00000367545.3	+	46	6668	c.6668C>T	c.(6667-6669)tCg>tTg	p.S2223L		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2223					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CATCGTACTTCGGAAATTTCA	0.398000													21	31					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49206576	49206576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49206576G>A	ENST00000425340.2	+	2	480	c.363G>A	c.(361-363)agG>agA	p.R121R	FUT2_ENST00000391876.4_Silent_p.R121R	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	121					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		CGGCCAGCAGGATCCCCTGGC	0.657000													28	53					0	0	1	0	0
FAM46C	54855	broad.mit.edu	37	1	118166571	118166571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:118166571C>T	ENST00000369448.3	+	2	1328	c.1081C>T	c.(1081-1083)Cct>Tct	p.P361S		NM_017709.3	NP_060179.2	Q5VWP2	FA46C_HUMAN	family with sequence similarity 46, member C	361										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	15	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CCAGCCGGCCCCTTACGTCAG	0.562000			"""Mis, F, O"""		MM					Multiple Myeloma(3;1.13e-06)			7	40					0	0	1	0	0
KRT84	3890	broad.mit.edu	37	12	52775175	52775175	+	Silent	SNP	C	C	T	rs114877532	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52775175C>T	ENST00000257951.3	-	5	1113	c.1047G>A	c.(1045-1047)cgG>cgA	p.R349R	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	349	Coil 2.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CAGCATCAGCCCGGCTGCGCC	0.577000													38	193					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179417421	179417421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179417421C>T	ENST00000589042.1	-	335	90430	c.90206G>A	c.(90205-90207)aGg>aAg	p.R30069K	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R27501K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R28428K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R21196K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R21129K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R21004K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28428	Fibronectin type-III 119.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTACCTTTCCTTTCTACAAC	0.448000													24	83					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219521016	219521016	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219521016G>A	ENST00000411696.2	-	3	916	c.137C>T	c.(136-138)tCc>tTc	p.S46F	ZNF142_ENST00000449707.1_Missense_Mutation_p.S46F			P52746	ZN142_HUMAN	zinc finger protein 142	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGGTCCCGGGAAGGACAGGG	0.602000													35	60					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39109233	39109233	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:39109233C>T	ENST00000297668.6	-	15	2362	c.2289G>A	c.(2287-2289)caG>caA	p.Q763Q	CNTNAP3_ENST00000377656.2_Silent_p.Q762Q|CNTNAP3_ENST00000358144.2_Silent_p.Q675Q	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	763	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCATCACAATCTGAGTGACTG	0.463000													17	27					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186672268	186672268	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:186672268G>A	ENST00000343098.5	+	17	18502	c.18502G>A	c.(18502-18504)Gaa>Aaa	p.E6168K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E6079K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TGATGATGATGAAATTATTCA	0.323000													96	92					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74287400	74287400	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74287400G>A	ENST00000262765.5	-	4	3089	c.2910C>T	c.(2908-2910)gcC>gcT	p.A970A		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	970							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						GTCGGTCCGAGGCTCGTGTTC	0.522000													23	42					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38311470	38311470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:38311470C>T	ENST00000553443.1	+	31	5635	c.5635C>T	c.(5635-5637)Ctt>Ttt	p.L1879F	TTC6_ENST00000267368.7_Missense_Mutation_p.L513F|TTC6_ENST00000382320.3_3'UTR|TTC6_ENST00000476979.1_Missense_Mutation_p.L513F					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		AGCACTTGATCTTGAAGACTA	0.363000													39	98					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803167	54803167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54803167G>A	ENST00000391745.1	-	8	877	c.561C>T	c.(559-561)tcC>tcT	p.S187S	LILRA3_ENST00000391744.3_Intron|LILRA3_ENST00000251390.3_Silent_p.S170S					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CATGGGAATGGGAGTTCAGGC	0.567000													55	105					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224609	248224609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248224609C>T	ENST00000359959.3	+	1	626	c.626C>T	c.(625-627)cCc>cTc	p.P209L	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTCGTGTTTCCCTTCATTGCT	0.507000													43	165					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141215075	141215075	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141215075G>A	ENST00000389484.3	-	61	10742	c.9771C>T	c.(9769-9771)gcC>gcT	p.A3257A		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3257					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATCTGTGATGGCATGCCATG	0.403000										TSP Lung(27;0.18)			20	197					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974783	49974783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49974783C>T	ENST00000555099.1	+	1	841	c.809C>T	c.(808-810)gCt>gTt	p.A270V		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						AAAGCAGTTGCTGTATTCTAC	0.378000													26	91					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20448675	20448675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20448675C>T	ENST00000331849.4	+	12	1669	c.1522C>T	c.(1522-1524)Ccc>Tcc	p.P508S		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	508					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CAGCCCAGACCCCATCAGGGG	0.572000													9	46					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716952	13716952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13716952C>T	ENST00000279593.3	-	13	3429	c.3220G>A	c.(3220-3222)Gag>Aag	p.E1074K		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1074					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCATTGCCCTCGATGTTCCCA	0.567000													16	22					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70890626	70890626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70890626C>T	ENST00000264436.3	-	16	2556	c.2112G>A	c.(2110-2112)aaG>aaA	p.K704K	ADD2_ENST00000407644.2_Silent_p.K704K|ADD2_ENST00000355733.3_3'UTR	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	704	Interaction with calmodulin (Potential).				actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						TCTTTTTCTTCTTTGAGGGAG	0.527000													119	233					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45867734	45867734	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45867734G>A	ENST00000391945.4	-	8	743	c.666C>T	c.(664-666)tcC>tcT	p.S222S	ERCC2_ENST00000221481.6_Intron|ERCC2_ENST00000391940.4_Silent_p.S198S|ERCC2_ENST00000485403.2_Silent_p.S198S|ERCC2_ENST00000391944.3_Silent_p.S144S	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	222	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCAGTTCCTTGGACACCAGGT	0.627000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				7	33					0	0	1	0	0
GPA33	10223	broad.mit.edu	37	1	167032894	167032894	+	Missense_Mutation	SNP	C	C	T	rs145965350		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167032894C>T	ENST00000367868.3	-	4	839	c.496G>A	c.(496-498)Gag>Aag	p.E166K	GPA33_ENST00000527955.1_5'UTR	NM_005814.1	NP_005805.1	Q99795	GPA33_HUMAN	glycoprotein A33 (transmembrane)	166	Ig-like C2-type.					integral to plasma membrane	receptor activity			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						GGTGAGCCCTCCTTTGATTGG	0.562000													33	103					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73044380	73044380	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73044380C>T	ENST00000604411.1	+	0	32341				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GTATTTAAACCCTTGGTTTGT	0.318000													9	6					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204953222	204953222	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204953222G>A	ENST00000367172.4	+	22	2866	c.2538G>A	c.(2536-2538)tgG>tgA	p.W846*	NFASC_ENST00000513543.1_Nonsense_Mutation_p.W842*|NFASC_ENST00000338586.6_Nonsense_Mutation_p.W846*|NFASC_ENST00000367169.4_Intron|NFASC_ENST00000360049.4_Nonsense_Mutation_p.W842*|NFASC_ENST00000367171.4_Nonsense_Mutation_p.W831*|NFASC_ENST00000401399.1_Intron|NFASC_ENST00000539706.1_Nonsense_Mutation_p.W842*|NFASC_ENST00000367170.4_Nonsense_Mutation_p.W846*|NFASC_ENST00000339876.6_Intron|NFASC_ENST00000404907.1_Nonsense_Mutation_p.W842*|NFASC_ENST00000404076.1_Nonsense_Mutation_p.W825*|NFASC_ENST00000338515.6_Nonsense_Mutation_p.W846*			O94856	NFASC_HUMAN	neurofascin	846	Fibronectin type-III 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GCCTTCAGTGGAACCGCGTCT	0.577000													10	53					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117681082	117681082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117681082C>T	ENST00000368508.3	-	23	3736	c.3538G>A	c.(3538-3540)Gca>Aca	p.A1180T	ROS1_ENST00000368507.3_Missense_Mutation_p.A1175T|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1180					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ACTCTTTCTGCTGAAAACGTC	0.403000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								41	52					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129149928	129149928	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:129149928C>T	ENST00000540052.1	+	3	3224	c.3180C>T	c.(3178-3180)ttC>ttT	p.F1060F	BCORL1_ENST00000218147.7_Silent_p.F1060F|BCORL1_ENST00000359304.2_Silent_p.F1060F|BCORL1_ENST00000303743.5_Silent_p.F1060F	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1060					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						ATGTGGTCTTCAATTTAGCCA	0.617000													22	14					0	0	1	0	0
C1orf222	339457	broad.mit.edu	37	1	1920052	1920052	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1920052C>T	ENST00000434971.2	-	4	227	c.195G>A	c.(193-195)aaG>aaA	p.K65K				Q69YW0	CA222_HUMAN	chromosome 1 open reading frame 222	0										breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)	11	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAGCTGTTTTCTTCTTCAATT	0.488000													27	66					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74860079	74860079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:74860079G>A	ENST00000358399.3	+	12	1244	c.1151G>A	c.(1150-1152)gGt>gAt	p.G384D	GDA_ENST00000238018.4_Missense_Mutation_p.G384D|GDA_ENST00000376986.1_Missense_Mutation_p.G306D|GDA_ENST00000376989.3_Missense_Mutation_p.G323D|GDA_ENST00000545168.1_Missense_Mutation_p.G310D	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	384					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GGGCTGGATGGTGAGATTGGA	0.448000													34	133					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42127077	42127077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42127077C>T	ENST00000382448.4	+	2	213	c.204C>T	c.(202-204)tcC>tcT	p.S68S	JMJD7_ENST00000397299.4_Silent_p.S68S|JMJD7-PLA2G4B_ENST00000342159.4_Silent_p.S68S|JMJD7-PLA2G4B_ENST00000542534.1_Silent_p.S68S|JMJD7_ENST00000408047.1_Intron	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		0	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						AGAAGTGGTCCCTCCCCTATT	0.617000													25	72					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416609	29416609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29416609G>A	ENST00000389048.3	-	29	5250	c.4344C>T	c.(4342-4344)tcC>tcT	p.S1448S	ALK_ENST00000431873.1_Silent_p.S278S	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1448					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCTTGCCAGAGGAGGTGGTAG	0.612000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				44	108					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90459638	90459638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90459638G>A	ENST00000405460.2	+	90	18938	c.18842G>A	c.(18841-18843)gGc>gAc	p.G6281D	GPR98_ENST00000425867.2_Missense_Mutation_p.G1942D	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6281					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTGGTCAAGGCAGCCAGGAG	0.488000													4	12					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2808585	2808585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:2808585G>A	ENST00000254695.8	+	3	178	c.88G>A	c.(88-90)Gag>Aag	p.E30K	RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.E30K|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.E11K|RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.E30K	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	30					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						CAGGAAGCAGGAGCTGGCCAA	0.592000													15	17					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380251	56380251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56380251G>A	ENST00000526538.1	-	1	727	c.728C>T	c.(727-729)tCc>tTc	p.S243F		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						TGTCAGGTGGGAAGCACACGT	0.448000													43	99					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648052	112648052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112648052G>A	ENST00000471858.1	-	3	668	c.436C>T	c.(436-438)Cac>Tac	p.H146Y	CD200R1_ENST00000308611.3_Missense_Mutation_p.H169Y|CD200R1_ENST00000440122.2_Missense_Mutation_p.H169Y|CD200R1_ENST00000295863.4_Missense_Mutation_p.H124Y|CD200R1_ENST00000490004.1_Missense_Mutation_p.H146Y	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	146	Ig-like C2-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						ACTTGGAGGTGATATCCACGA	0.418000													20	107					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36752667	36752667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36752667G>A	ENST00000354618.5	+	4	1060	c.836G>A	c.(835-837)aGc>aAc	p.S279N	THRAP3_ENST00000469141.2_Missense_Mutation_p.S279N	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	279	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCACTTTCCAGCACATCCCAG	0.612000			T	USP6	aneurysmal bone cysts								44	102					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47295229	47295229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47295229G>A	ENST00000225941.1	+	3	912	c.414G>A	c.(412-414)agG>agA	p.R138R	ABI3_ENST00000419580.2_Silent_p.R132R	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	138					cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			CCTACTGCAGGAGACCCCTCA	0.632000										HNSCC(55;0.14)			25	117					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62299448	62299448	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62299448G>A	ENST00000371158.2	+	17	2217	c.2103G>A	c.(2101-2103)ttG>ttA	p.L701L	INADL_ENST00000316485.6_Silent_p.L701L	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	701	PDZ 5.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TCAGCATTTTGGATTACCAGG	0.378000													25	125					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19471629	19471629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19471629G>A	ENST00000396229.2	+	6	1870	c.1121G>A	c.(1120-1122)aGg>aAg	p.R374K	TMC5_ENST00000219821.5_Missense_Mutation_p.R128K|TMC5_ENST00000542583.2_Missense_Mutation_p.R374K|TMC5_ENST00000541464.1_Missense_Mutation_p.R374K|TMC5_ENST00000381414.4_Missense_Mutation_p.R374K|TMC5_ENST00000561503.1_Missense_Mutation_p.R15K|TMC5_ENST00000564959.1_Missense_Mutation_p.R36K	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	374						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AACCAGCCAAGGACCATGGAA	0.398000													17	40					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19740991	19740991	+	Silent	SNP	G	G	A	rs144936310	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19740991G>A	ENST00000203556.4	-	21	2831	c.2694C>T	c.(2692-2694)acC>acT	p.T898T	GMIP_ENST00000587238.1_Silent_p.T872T|GMIP_ENST00000445806.2_Silent_p.T869T	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	898					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						ATGTGATGGGGGTCTCCTCGC	0.701000													8	25					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1836644	1836644	+	Silent	SNP	G	G	A	rs144059275	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1836644G>A	ENST00000302787.2	-	5	1100	c.804C>T	c.(802-804)atC>atT	p.I268I		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	268	LETM1.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			CCATCTCCTCGATGGTGTCCT	0.562000													22	69					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55174518	55174518	+	Splice_Site	SNP	C	C	T	rs141935558		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55174518C>T	ENST00000391736.1	+	3	348	c.34_splice	c.e3+1	p.L11_splice	LILRB4_ENST00000270452.2_Splice_Site_p.L11_splice|LILRB4_ENST00000391734.3_Splice_Site_p.L11_splice|LILRB4_ENST00000391733.3_Splice_Site_p.L11_splice|LILRB4_ENST00000430952.2_Splice_Site_p.L11_splice	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	11						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		TGCTCTGCCTCGGTGAGATTT	0.577000											OREG0003670	type=REGULATORY REGION|Gene=LILRB4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	73					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115815860	115815860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:115815860G>A	ENST00000343348.6	-	12	1995	c.1208C>T	c.(1207-1209)cCc>cTc	p.P403L	CTB-118N6.3_ENST00000514214.1_RNA|CTB-118N6.3_ENST00000510682.1_RNA|SEMA6A_ENST00000510263.1_Missense_Mutation_p.P403L|CTB-118N6.3_ENST00000508640.1_RNA|SEMA6A_ENST00000257414.8_Missense_Mutation_p.P403L	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	403	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GAAGATGGAGGGCACTGCCTC	0.498000													38	79					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122846208	122846208	+	Missense_Mutation	SNP	G	G	A	rs145694364		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122846208G>A	ENST00000264811.5	-	2	1340	c.922C>T	c.(922-924)Cgt>Tgt	p.R308C	TRPC3_ENST00000379645.3_Missense_Mutation_p.R381C|TRPC3_ENST00000513531.1_Missense_Mutation_p.R308C	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	296					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						AGTTTGACACGACTTAATGAA	0.428000													34	161					0	0	1	0	0
P4HTM	54681	broad.mit.edu	37	3	49042403	49042403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49042403C>T	ENST00000343546.4	+	6	1365	c.997C>T	c.(997-999)Cct>Tct	p.P333S	P4HTM_ENST00000383729.4_Missense_Mutation_p.P333S	NM_177938.2	NP_808807.2	Q9NXG6	P4HTM_HUMAN	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	333	Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21					Vitamin C(DB00126)	GGACAGTGGGCCTGTGTACCC	0.612000													25	56					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177034349	177034349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:177034349G>A	ENST00000468418.3	+	3	2597	c.507G>A	c.(505-507)caG>caA	p.Q169Q	HOXD3_ENST00000249440.3_Silent_p.Q169Q|HOXD3_ENST00000410016.1_Silent_p.Q169Q			P31249	HXD3_HUMAN	homeobox D3	169					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGTCTCGACAGAACTCCAAGC	0.572000													52	111					0	0	1	0	0
PSKH2	85481	broad.mit.edu	37	8	87076389	87076389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87076389C>T	ENST00000276616.2	-	2	731	c.657G>A	c.(655-657)atG>atA	p.M219I	PSKH2_ENST00000517981.1_5'UTR	NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	219	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			AGAGTGTCTTCATTGTCCAGT	0.438000													7	77					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141260537	141260537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141260537C>T	ENST00000389484.3	-	54	9628	c.8657G>A	c.(8656-8658)aGt>aAt	p.S2886N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2886					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTACCTGCACTTTTACACTT	0.368000										TSP Lung(27;0.18)			19	80					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115399878	115399878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115399878C>T	ENST00000369522.3	+	4	459	c.219C>T	c.(217-219)ttC>ttT	p.F73F	SYCP1_ENST00000369518.1_Silent_p.F73F	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	73	Asp/Glu-rich (acidic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGTTAATTTCTTGCCCGTGC	0.313000													10	43					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77607174	77607174	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:77607174G>A	ENST00000461745.1	+	9	2211	c.1311G>A	c.(1309-1311)ctG>ctA	p.L437L	ROBO2_ENST00000487694.3_Silent_p.L453L|ROBO2_ENST00000332191.8_Silent_p.L437L	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	437	Ig-like C2-type 5.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAGCGTTACTGAAATGTAAAG	0.438000													39	77					0	0	1	0	0
LRRC19	64922	broad.mit.edu	37	9	26999654	26999654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:26999654G>A	ENST00000380055.5	-	2	149	c.39C>T	c.(37-39)ctC>ctT	p.L13L	IFT74_ENST00000443698.1_Intron|IFT74_ENST00000380062.5_Intron|IFT74_ENST00000433700.1_Intron|IFT74_ENST00000429045.2_Intron	NM_022901.2	NP_075052.1	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19	13						integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)	6		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)		ATATCATGGAGAGGGGCCAAA	0.303000													20	27					0	0	1	0	0
GBAS	2631	broad.mit.edu	37	7	56065061	56065061	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:56065061T>G	ENST00000322090.3	+	9	744	c.715T>G	c.(715-717)Tac>Gac	p.Y239D	GBAS_ENST00000446778.1_Missense_Mutation_p.Y200D	NM_001483.2	NP_001474.1	O75323	NIPS2_HUMAN	glioblastoma amplified sequence	239						integral to plasma membrane|membrane fraction|mitochondrion	protein binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(2)	5	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTTTTAAGCTTACAGGGATCT	0.418000													32	83					0	0	1	0	0
RIPPLY3	53820	broad.mit.edu	37	21	38380522	38380522	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38380522C>T	ENST00000329553.2	+	2	380	c.171_splice	c.e2+1	p.P57_splice	RIPPLY3_ENST00000485272.1_3'UTR	NM_018962.2	NP_061835.1			ripply transcriptional repressor 3																		ACTGGAAGGCCGGTAAGGTTC	0.597000													17	37					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55961752	55961752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55961752G>A	ENST00000263923.4	-	20	3104	c.2809C>T	c.(2809-2811)Ccc>Tcc	p.P937S		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	937	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ACCTTGTAGGGGACAAATTCA	0.423000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			22	59					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815176	106815176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106815176G>A	ENST00000407775.2	+	8	3116	c.2866G>A	c.(2866-2868)Gaa>Aaa	p.E956K	ZFPM2_ENST00000520492.1_Missense_Mutation_p.E824K|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.E687K|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.E824K|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	956					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TGCTACAAAAGAAGAAAACAG	0.443000													5	21					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82579556	82579556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82579556C>T	ENST00000423517.2	-	6	10685	c.10348G>A	c.(10348-10350)Gaa>Aaa	p.E3450K	PCLO_ENST00000437081.1_Missense_Mutation_p.E170K|PCLO_ENST00000333891.8_Missense_Mutation_p.E3450K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3381					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTGGCATCTTCGTCATCCGTT	0.438000													30	68					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80655837	80655837	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80655837C>T	ENST00000458043.2	+	18	1957	c.1951C>T	c.(1951-1953)Cca>Tca	p.P651S	OTOGL_ENST00000547103.1_Missense_Mutation_p.P651S	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TGTTCATGTCCCAGTGGTGGA	0.403000													47	62					0	0	1	0	0
PRMT1	3276	broad.mit.edu	37	19	50188094	50188094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50188094C>T	ENST00000532489.1	+	7	1007	c.501C>T	c.(499-501)atC>atT	p.I167I	PRMT1_ENST00000391851.4_Silent_p.I195I|PRMT1_ENST00000454376.2_Silent_p.I213I			Q8WUW5	Q8WUW5_HUMAN	protein arginine methyltransferase 1	194						cytoplasm	protein methyltransferase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(2)	12		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00103)|GBM - Glioblastoma multiforme(134;0.012)		ACTACAAGATCCACTGTGAGC	0.692000											OREG0025627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	17					0	0	1	0	0
HAS3	3038	broad.mit.edu	37	16	69143776	69143776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:69143776G>A	ENST00000306560.1	+	2	634	c.478G>A	c.(478-480)Gag>Aag	p.E160K	HAS3_ENST00000569188.1_Missense_Mutation_p.E160K|HAS3_ENST00000219322.3_Missense_Mutation_p.E160K	NM_005329.2	NP_005320.2	O00219	HAS3_HUMAN	hyaluronan synthase 3	160					carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|urinary_tract(2)	16		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		TGAGGCAGGCGAGGGTGAGAC	0.647000													13	60					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68984806	68984806	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68984806G>A	ENST00000288368.4	+	14	1846		c.e14+1		PREX2_ENST00000529398.1_Splice_Site	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2						G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AATTGCACAGGTAAATAGACA	0.348000													11	114					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53342917	53342917	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:53342917C>T	ENST00000226067.5	+	1	545	c.72C>T	c.(70-72)tcC>tcT	p.S24S		NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	24					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						TGCTCAGGTCCCTGCTGGAGA	0.642000			T	TCF3	ALL								4	30					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14367010	14367010	+	Silent	SNP	C	C	T	rs141984882		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14367010C>T	ENST00000344204.4	+	16	2820	c.2796C>T	c.(2794-2796)gcC>gcT	p.A932A	TRIO_ENST00000537187.1_Silent_p.A932A|TRIO_ENST00000509967.2_Silent_p.A883A	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	932					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TGTTAAATGCCGGACTTATCA	0.552000													17	92					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234442224	234442224	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234442224G>A	ENST00000251722.6	-	11	1486	c.1369C>T	c.(1369-1371)Cag>Tag	p.Q457*	USP40_ENST00000450966.1_Nonsense_Mutation_p.Q469*|USP40_ENST00000427112.2_Nonsense_Mutation_p.Q457*			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	457					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CTGATTGGCTGGACTTTAGAA	0.423000													31	74					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54617532	54617532	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:54617532G>A	ENST00000302287.3	+	4	709	c.303G>A	c.(301-303)gtG>gtA	p.V101V	VSTM2A_ENST00000407838.3_Silent_p.V101V|VSTM2A_ENST00000402026.2_Silent_p.V100V|VSTM2A_ENST00000498834.1_3'UTR|VSTM2A_ENST00000402613.3_Silent_p.V101V|VSTM2A_ENST00000404951.1_Silent_p.V101V			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	101	Ig-like V-type.					extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			TTCAGACAGTGAAAGTCCAAG	0.378000													7	22					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140732107	140732107	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140732107G>A	ENST00000523390.1	+	1	2280	c.2280G>A	c.(2278-2280)gaG>gaA	p.E760E	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAGACAGAGTTTAATTCTC	0.488000													11	54					0	0	1	0	0
GGN	199720	broad.mit.edu	37	19	38877095	38877095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38877095C>T	ENST00000334928.6	-	3	939	c.807G>A	c.(805-807)ggG>ggA	p.G269G	GGN_ENST00000591809.1_Intron|AC005789.9_ENST00000585411.1_RNA	NM_152657.3	NP_689870.3	Q86UU5	GGN_HUMAN	gametogenetin	269	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTCCGCCGCCCCCCAGCGAAG	0.652000													17	44					0	0	1	0	0
PNPLA8	50640	broad.mit.edu	37	7	108119732	108119732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:108119732G>A	ENST00000426128.2	-	9	1909	c.1784C>T	c.(1783-1785)tCc>tTc	p.S595F	PNPLA8_ENST00000436062.1_Missense_Mutation_p.S657F|PNPLA8_ENST00000453144.1_Missense_Mutation_p.S557F|PNPLA8_ENST00000257694.8_Missense_Mutation_p.S657F|PNPLA8_ENST00000388728.5_Missense_Mutation_p.S595F|PNPLA8_ENST00000422087.1_Missense_Mutation_p.S657F	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	657	Patatin.				fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						AGTGCCCAGGGATACTATGCA	0.418000													40	117					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151945118	151945118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151945118G>A	ENST00000355193.2	-	14	2619	c.2401C>T	c.(2401-2403)Cct>Tct	p.P801S	KMT2C_ENST00000262189.6_Missense_Mutation_p.P801S					lysine (K)-specific methyltransferase 2C																		AGAGCTGAAGGGTAATTATGC	0.433000													47	883					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	124097411	124097411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:124097411C>T	ENST00000422452.2	-	1	255	c.192G>A	c.(190-192)agG>agA	p.R64R	TENM1_ENST00000371130.3_Silent_p.R64R	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CTACTTCTTTCCTCTTTCTAC	0.358000													23	119					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72367986	72367986	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72367986C>T	ENST00000335666.4	+	4	684	c.636C>T	c.(634-636)ttC>ttT	p.F212F		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	212						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						TCATCGTGTTCGCGGGCTTCC	0.652000													14	20					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5545195	5545195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5545195G>A	ENST00000382368.3	-	2	208	c.85C>T	c.(85-87)Cta>Tta	p.L29L	FBXL18_ENST00000453700.3_Silent_p.L29L	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	29	F-box.								FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GAGAACCCTAGGAGGTGGACC	0.552000													29	59					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802134	185802134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185802134G>A	ENST00000302277.6	+	4	2605	c.2011G>A	c.(2011-2013)Gaa>Aaa	p.E671K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	671						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAGTGACAATGAAGAAATGTG	0.313000													28	94					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87195420	87195420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87195420G>A	ENST00000265724.3	-	8	1085	c.668C>T	c.(667-669)cCt>cTt	p.P223L	ABCB1_ENST00000543898.1_Missense_Mutation_p.P159L	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	223	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCCAAGAACAGGACTGATGGC	0.463000													22	57					0	0	1	0	0
ZBTB34	403341	broad.mit.edu	37	9	129642196	129642196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:129642196C>T	ENST00000319119.4	+	2	603	c.518C>T	c.(517-519)tCt>tTt	p.S173F	ZBTB34_ENST00000373452.2_Missense_Mutation_p.S169F	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						CCATATTGCTCTCAGGGACGG	0.587000													38	57					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68950492	68950492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68950492C>T	ENST00000288368.4	+	7	1081	c.804C>T	c.(802-804)ttC>ttT	p.F268F	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	268	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.F268F(2)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TTTTTCTTTTCGATAATCTTT	0.413000													24	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074867	9074867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9074867G>A	ENST00000397910.4	-	3	12782	c.12579C>T	c.(12577-12579)ttC>ttT	p.F4193F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4195	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCAGACAAGAAAACTGAGG	0.507000													20	59					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166418738	166418738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:166418738G>A	ENST00000402744.4	+	9	1687	c.1407G>A	c.(1405-1407)atG>atA	p.M469I		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	469					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTGGAAAATGATGTCAGAAA	0.289000													24	56					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142481378	142481378	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142481378G>A	ENST00000603901.1	+	0	452					NR_001296.3																						CTGAGCTCTGGGGGTGAGTGG	0.547000													4	22					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150773146	150773146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150773146G>A	ENST00000370357.4	+	3	302	c.57G>A	c.(55-57)agG>agA	p.R19R		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	19						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCTCAAAGGAAATTAAACT	0.333000													15	8					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48796017	48796017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48796017C>T	ENST00000316623.5	-	17	2535	c.2080G>A	c.(2080-2082)Gaa>Aaa	p.E694K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	694	TB 3.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGGCAAGGTTCCCCAAATGCA	0.493000													28	71					0	0	1	0	0
METTL17	64745	broad.mit.edu	37	14	21464991	21464991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21464991C>T	ENST00000339374.6	+	14	1546	c.1313C>T	c.(1312-1314)cCt>cTt	p.P438L	METTL17_ENST00000382985.4_Silent_p.T462T|METTL17_ENST00000556670.2_Missense_Mutation_p.P429L|RP11-84C10.4_ENST00000557335.1_RNA	NM_001029991.1|NM_022734.2	NP_001025162.1|NP_073571.1	Q9H7H0	MET17_HUMAN	methyltransferase like 17	438					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						GATCTTTTACCTGTGCTTACT	0.522000													39	94					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95683710	95683710	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95683710C>T	ENST00000433389.2	+	11	1453	c.1263C>T	c.(1261-1263)ctC>ctT	p.L421L	ESRP1_ENST00000358397.5_Silent_p.L421L|ESRP1_ENST00000454170.2_Silent_p.L421L|ESRP1_ENST00000423620.2_Silent_p.L421L	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	421					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						CGGCCCCTCTCATTCCACTTC	0.483000													16	82					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46067533	46067533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46067533C>T	ENST00000295452.4	-	4	557	c.390G>A	c.(388-390)atG>atA	p.M130I		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	130					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TAAGCACTTTCATGGTACTAT	0.313000													16	44					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37146532	37146532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:37146532C>T	ENST00000262879.6	+	9	1590	c.1306C>T	c.(1306-1308)Cgg>Tgg	p.R436W	RALGAPB_ENST00000397042.3_Missense_Mutation_p.R436W|RALGAPB_ENST00000397040.1_Missense_Mutation_p.R436W|RALGAPB_ENST00000537204.1_Missense_Mutation_p.R436W|RALGAPB_ENST00000397038.1_Missense_Mutation_p.R214W			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	436					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity	p.R436R(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						GCCTGCCCCTCGGAGACCAAA	0.468000													41	75					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6128444	6128444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6128444G>A	ENST00000261405.5	-	28	4394	c.4140C>T	c.(4138-4140)atC>atT	p.I1380I		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1380	VWFA 1; binding site for platelet glycoprotein Ib.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GGAGCAGGGTGATGCGGGAGG	0.582000													15	62					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56233261	56233261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56233261G>A	ENST00000268912.5	+	1	768	c.747G>A	c.(745-747)atG>atA	p.M249I		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M249I(1)		kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TGGTGTCCATGATCTTCATTC	0.522000													11	78					0	0	1	0	0
TUBA1A	7846	broad.mit.edu	37	12	49579395	49579395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49579395G>A	ENST00000301071.7	-	4	1098	c.754C>T	c.(754-756)Ctg>Ttg	p.L252L	TUBA1A_ENST00000550767.1_Silent_p.L217L|TUBA1A_ENST00000295766.5_Silent_p.L252L	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	252					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						AATTCTGTCAGGTCAACATTC	0.488000													27	72					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62676119	62676119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62676119C>T	ENST00000498273.1	+	4	1968	c.1673C>T	c.(1672-1674)cCc>cTc	p.P558L		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	558										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						TTGGCCTCTCCCTCAAAGTCA	0.438000													29	70					0	0	1	0	0
HOXC8	3224	broad.mit.edu	37	12	54405148	54405148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54405148G>A	ENST00000040584.4	+	2	949	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_022658.3	NP_073149.1	P31273	HXC8_HUMAN	homeobox C8	238						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	8						ggaggaaaaggaagaAAACAA	0.448000													20	57					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69409628	69409628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69409628C>T	ENST00000303714.4	+	16	1511	c.1189C>T	c.(1189-1191)Cgt>Tgt	p.R397C		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	397					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						ATTTTAGGTTCGTTGGGGAGA	0.413000									Familial Infantile Hemangioma				14	37					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142633	48142633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48142633G>A	ENST00000405493.2	-	11	1206	c.997C>T	c.(997-999)Cct>Tct	p.P333S	RAPGEF3_ENST00000548919.1_Missense_Mutation_p.P333S|RAPGEF3_ENST00000449771.2_Missense_Mutation_p.P375S|RAPGEF3_ENST00000395358.3_Missense_Mutation_p.P375S|RAPGEF3_ENST00000549151.1_Missense_Mutation_p.P333S|RAPGEF3_ENST00000389212.3_Missense_Mutation_p.P375S|RAPGEF3_ENST00000171000.4_Missense_Mutation_p.P333S	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	333					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GGTCGGGAAGGGCCGGCGCCC	0.597000													41	107					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9086521	9086521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9086521C>T	ENST00000397910.4	-	1	5497	c.5294G>A	c.(5293-5295)gGc>gAc	p.G1765D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1765	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAATGTGCTGCCCCCTATGAA	0.502000													6	73					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50295006	50295006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50295006C>T	ENST00000320634.3	-	2	212	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K	FAIM2_ENST00000550890.1_5'UTR	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	40					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						GAGGTGGCTTCCTCATAGGAG	0.667000													12	45					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119031618	119031618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119031618G>A	ENST00000307417.3	+	15	2107	c.1743G>A	c.(1741-1743)acG>acA	p.T581T	ABCG4_ENST00000531739.1_Silent_p.T581T|ABCG4_ENST00000449422.2_Silent_p.T581T	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	581	ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity	p.T581T(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGATCCTGACGATCTATGGCA	0.572000													14	29					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96789678	96789678	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96789678C>T	ENST00000342380.2	-	9	1206	c.1207G>A	c.(1207-1209)Gga>Aga	p.G403R		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	403					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						GGCTGGATTCCTGCTTCTGAA	0.592000													30	67					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688703	26688703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26688703C>T	ENST00000529632.2	+	2	622	c.426C>T	c.(424-426)gtC>gtT	p.V142V	SEZ6L_ENST00000360929.3_Silent_p.V142V|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000404234.3_Silent_p.V142V|SEZ6L_ENST00000343706.4_Silent_p.V142V|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000248933.6_Silent_p.V142V	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	142						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CAGCCACTGTCCAAAGGGCAG	0.662000													12	35					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165984197	165984197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165984197C>T	ENST00000360093.3	-	18	3828	c.3337G>A	c.(3337-3339)Gaa>Aaa	p.E1113K	SCN3A_ENST00000283254.7_Missense_Mutation_p.E1113K|SCN3A_ENST00000409101.3_Missense_Mutation_p.E1064K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1113						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TTTAAGTTTTCAAAGTCAGAC	0.358000													38	78					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107734	55107734	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55107734C>T	ENST00000251372.3	+	7	1221	c.1039C>T	c.(1039-1041)Cag>Tag	p.Q347*	LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000453777.1_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	347	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		CCTGCTGTGTCAGTCATGGGG	0.592000													27	86					0	0	1	0	0
PARP16	54956	broad.mit.edu	37	15	65559098	65559098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65559098C>T	ENST00000261888.6	-	3	766	c.321G>A	c.(319-321)aaG>aaA	p.K107K	PARP16_ENST00000558873.1_5'UTR|PARP16_ENST00000444347.2_Intron	NM_017851.4	NP_060321.3	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	107	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						GCTTTTGGATCTTTTCAAACT	0.438000													6	34					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67066438	67066438	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:67066438G>T	ENST00000315962.4	+	9	1766	c.1393G>T	c.(1393-1395)Ggt>Tgt	p.G465C	TRIM55_ENST00000350034.4_Intron|TRIM55_ENST00000353317.5_Intron|TRIM55_ENST00000276573.7_Missense_Mutation_p.G465C	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	465						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			AGGGAGCGAAGGTCTGGGGCA	0.567000													7	67					8.12818e-05	8.14046e-05	1	1	0
ADCY10	55811	broad.mit.edu	37	1	167865839	167865839	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167865839G>T	ENST00000367848.1	-	7	954	c.457C>A	c.(457-459)Cac>Aac	p.H153N	ADCY10_ENST00000367851.4_Missense_Mutation_p.H245N|ADCY10_ENST00000545172.1_Missense_Mutation_p.H92N			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	245	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTACTTTTGTGCTCACCAGAA	0.398000													99	235					3.69185e-53	3.71836e-53	1	1	0
PGBD1	84547	broad.mit.edu	37	6	28269783	28269783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28269783G>A	ENST00000405948.2	+	7	2572	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	PGBD1_ENST00000259883.3_Missense_Mutation_p.E718K	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	718					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						TGCTGATAACGAAGAAATCCC	0.403000													21	118					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100144721	100144721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:100144721C>T	ENST00000370575.4	-	15	1706	c.1658G>A	c.(1657-1659)gGa>gAa	p.G553E	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	553							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						AGCCCCACTTCCACAGAGATA	0.612000													8	20					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164781252	164781252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:164781252G>A	ENST00000420696.2	+	6	1051	c.863G>A	c.(862-864)cGa>cAa	p.R288Q	PBX1_ENST00000540236.1_Missense_Mutation_p.R288Q|PBX1_ENST00000560641.1_Missense_Mutation_p.R183Q|PBX1_ENST00000401534.1_Missense_Mutation_p.R288Q|PBX1_ENST00000540246.1_Missense_Mutation_p.R183Q|PBX1_ENST00000559240.1_Intron|PBX1_ENST00000367897.1_Missense_Mutation_p.R288Q	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	288					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						GGAAATAAGCGAATCCGGTAC	0.388000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								21	53					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126062903	126062903	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:126062903T>C	ENST00000318410.7	-	18	2451	c.2102A>G	c.(2101-2103)gAt>gGt	p.D701G	KIAA0196_ENST00000517845.1_Missense_Mutation_p.D553G	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	701					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTGCTTTGGATCCACCTAAGT	0.448000													15	67					0	0	1	0	0
C15orf43	145645	broad.mit.edu	37	15	45248981	45248981	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45248981G>A	ENST00000340827.3	+	1	81		c.e1+1			NM_152448.2	NP_689661.1	Q8NHR7	CO043_HUMAN	chromosome 15 open reading frame 43											NS(1)|breast(2)|large_intestine(1)|lung(2)|skin(2)	8		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		CAATTCTGGGGTAGGAAGCTG	0.582000													23	61					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3180142	3180142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3180142C>T	ENST00000355072.5	+	35	4726	c.4581C>T	c.(4579-4581)atC>atT	p.I1527I		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1527					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTGATGGCATCATGGCCAGTG	0.418000													31	124					0	0	1	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767608	143767608	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:143767608C>A	ENST00000419275.1	-	1	273	c.241G>T	c.(241-243)Gag>Tag	p.E81*		NM_001123068.1	NP_001116540.1	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like 4G	81	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(2)|kidney(1)|lung(8)|ovary(1)|skin(1)	14						TCAAATTTCTCCCCATAGATG	0.453000													63	245					3.58576e-35	3.611e-35	1	1	0
SHE	126669	broad.mit.edu	37	1	154461646	154461646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154461646C>T	ENST00000304760.2	-	3	991	c.905G>A	c.(904-906)aGg>aAg	p.R302K		NM_001010846.2	NP_001010846.1	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	302										breast(4)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	14	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCCCTCTGCCCTGGGCCCCCC	0.647000													23	55					0	0	1	0	0
ATP5A1	498	broad.mit.edu	37	18	43678154	43678154	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43678154G>A	ENST00000282050.2	-	2	188	c.44C>T	c.(43-45)cCt>cTt	p.P15L	ATP5A1_ENST00000593152.2_5'UTR|ATP5A1_ENST00000590665.1_Missense_Mutation_p.P15L|ATP5A1_ENST00000398752.6_Missense_Mutation_p.P15L|ATP5A1_ENST00000591267.1_5'UTR	NM_001001937.1	NP_001001937.1	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	15					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						GGCCCGCCGAGGAAGGGCGCG	0.711000													11	31					0	0	1	0	0
CERS6	253782	broad.mit.edu	37	2	169487532	169487532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169487532G>A	ENST00000305747.6	+	4	1032	c.445G>A	c.(445-447)Gga>Aga	p.G149R	CERS6_ENST00000392687.4_Missense_Mutation_p.G149R	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	149	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity	p.G149*(1)									ATTTACCTACGGAGTCAGATT	0.299000													21	92					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20994161	20994161	+	Missense_Mutation	SNP	G	G	A	rs145048646		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20994161G>A	ENST00000261383.3	-	49	7740	c.7741C>T	c.(7741-7743)Cct>Tct	p.P2581S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2581	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATCAGCGAAGGGAACATCCGC	0.488000													36	79					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39087296	39087296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39087296C>T	ENST00000400482.3	-	3	753	c.164G>A	c.(163-165)aGg>aAg	p.R55K	KCNJ6_ENST00000288309.6_Missense_Mutation_p.R55K	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	55					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CCTCACGTACCTCTGGATTTT	0.522000													35	121					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440502	40440502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40440502G>A	ENST00000319592.4	-	4	1118	c.409C>T	c.(409-411)Cgc>Tgc	p.R137C	RBM47_ENST00000381793.2_Missense_Mutation_p.R137C|RBM47_ENST00000381795.6_Missense_Mutation_p.R137C|RBM47_ENST00000295971.7_Missense_Mutation_p.R137C|RBM47_ENST00000514014.1_Missense_Mutation_p.R99C|RBM47_ENST00000515809.1_Intron			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	137	RRM 1.					nucleus	nucleotide binding|RNA binding	p.R137C(3)		breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CGGCCCGGGCGGATCTCGTAG	0.622000													26	42					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826190	43826190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43826190C>T	ENST00000389420.3	-	21	3012	c.3013G>A	c.(3013-3015)Gaa>Aaa	p.E1005K	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.E159K|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E1005K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1005	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCTTGGCATTCATTGTCAGCA	0.428000													39	53					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100266060	100266060	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100266060C>T	ENST00000515683.1	-	0	877				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	GTCGAAAATCCACAGCCAATG	0.507000													43	117					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123966241	123966241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:123966241C>T	ENST00000314393.4	+	3	3326	c.2491C>T	c.(2491-2493)Cct>Tct	p.P831S		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	831						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CGACTGCGTCCCTGCAGAGGC	0.567000													6	25					0	0	1	0	0
MYEOV2	150678	broad.mit.edu	37	2	241069402	241069402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241069402G>A	ENST00000307266.3	-	4	306	c.307C>T	c.(307-309)Ccc>Tcc	p.P103S		NM_138336.1	NP_612209.1	Q8WXC6	MYOV2_HUMAN	myeloma overexpressed 2	0										breast(1)|lung(5)|pancreas(1)	7		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		TGCAGTGCGGGAACCATGGAG	0.602000													20	47					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21641177	21641177	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21641177A>T	ENST00000328843.6	+	18	3620	c.3589A>T	c.(3589-3591)Atc>Ttc	p.I1197F	DNAH11_ENST00000409508.3_Missense_Mutation_p.I1197F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1197	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AAAAGAAACGATCACCCTCTT	0.418000									Kartagener syndrome				9	19					0	0	1	0	0
ELAVL3	1995	broad.mit.edu	37	19	11568980	11568980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11568980C>T	ENST00000359227.3	-	5	1033	c.609G>A	c.(607-609)gcG>gcA	p.A203A	ELAVL3_ENST00000438662.2_Silent_p.A203A	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	203	RRM 2.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding	p.A203A(1)		breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						TTGGGTTGTTCGCGAACTTGA	0.602000													29	64					0	0	1	0	0
TRH	7200	broad.mit.edu	37	3	129694861	129694861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129694861G>A	ENST00000302649.3	+	2	729	c.202G>A	c.(202-204)Gag>Aag	p.E68K	TRH_ENST00000507066.1_Intron	NM_007117.3	NP_009048.1	P20396	TRH_HUMAN	thyrotropin-releasing hormone	68					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)	14						GGACCAGGGTGAGCACTCCGG	0.667000													13	24					0	0	1	0	0
BEND6	221336	broad.mit.edu	37	6	56857310	56857310	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56857310G>A	ENST00000370748.3	+	3	690	c.255G>A	c.(253-255)cgG>cgA	p.R85R	BEND6_ENST00000370750.2_Silent_p.R85R|BEND6_ENST00000370745.1_Silent_p.R85R|BEND6_ENST00000370746.3_Silent_p.R85R			Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	85										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						CAAACACCCGGAAAGAAAACA	0.383000													32	190					0	0	1	0	0
SPINK7	84651	broad.mit.edu	37	5	147693756	147693756	+	Missense_Mutation	SNP	G	G	A	rs138587974		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147693756G>A	ENST00000274565.4	+	3	242	c.181G>A	c.(181-183)Ggg>Agg	p.G61R	SPINK7_ENST00000514394.1_3'UTR|RP11-373N22.3_ENST00000501695.3_RNA|SPINK7_ENST00000523535.1_Missense_Mutation_p.G35R	NM_032566.2	NP_115955.1	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7 (putative)	61	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCACCTATGGGAATGAATG	0.468000													17	123					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71887770	71887770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71887770C>T	ENST00000258104.3	+	44	5152	c.4875C>T	c.(4873-4875)ccC>ccT	p.P1625P	DYSF_ENST00000410041.1_Silent_p.P1643P|DYSF_ENST00000429174.2_Silent_p.P1646P|DYSF_ENST00000409744.1_Silent_p.P1633P|DYSF_ENST00000410020.3_Silent_p.P1664P|DYSF_ENST00000394120.2_Silent_p.P1626P|DYSF_ENST00000409366.1_Silent_p.P1647P|DYSF_ENST00000409582.3_Silent_p.P1663P|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Silent_p.P1656P|DYSF_ENST00000409651.1_Silent_p.P1657P|DYSF_ENST00000409762.1_Silent_p.P1642P	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1625	C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CGCTGGAGCCCGTATTTGGAA	0.507000													16	37					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125555795	125555795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125555795G>A	ENST00000431078.1	+	19	3476	c.3112G>A	c.(3112-3114)Gaa>Aaa	p.E1038K		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1038	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCCATCCAAGGAAAACATTGC	0.438000													20	35					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41482155	41482155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41482155C>T	ENST00000314992.5	-	9	1052	c.862G>A	c.(862-864)Gac>Aac	p.D288N	EXD1_ENST00000458580.2_Missense_Mutation_p.D346N	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	288					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						CCAAGCCGGTCTGCAGACCCT	0.527000													26	69					0	0	1	0	0
MR1	3140	broad.mit.edu	37	1	181021631	181021631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181021631C>T	ENST00000367580.5	+	4	870	c.865C>T	c.(865-867)Ctt>Ttt	p.L289F	MR1_ENST00000367579.3_Missense_Mutation_p.L244F|MR1_ENST00000282990.6_Intron|MR1_ENST00000438435.2_Intron|MR1_ENST00000434571.2_Intron	NM_001531.2	NP_001522.1	Q95460	HMR1_HUMAN	major histocompatibility complex, class I-related	289	Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	18						CCACATGGTTCTTCAGGTCCC	0.582000													19	37					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183197559	183197559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183197559G>A	ENST00000264144.4	+	11	1584	c.1519G>A	c.(1519-1521)Gaa>Aaa	p.E507K	LAMC2_ENST00000493293.1_Missense_Mutation_p.E507K	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	507	Laminin EGF-like 6.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						CCCCTTTGGTGAACATGGCCC	0.557000											OREG0014041	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	68					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55925701	55925701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55925701C>T	ENST00000244728.5	-	26	2737	c.2340G>A	c.(2338-2340)ttG>ttA	p.L780L	COL21A1_ENST00000535941.1_Silent_p.L780L|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Silent_p.L180L|COL21A1_ENST00000370819.1_Silent_p.L777L	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	780	Collagen-like 5.			L -> W (in Ref. 7; AAH45597).	cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GCTTCCCATCCAAACCTGGGG	0.478000													26	31					0	0	1	0	0
ZNF280D	54816	broad.mit.edu	37	15	56961140	56961140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:56961140G>A	ENST00000559237.1	-	13	2070	c.1387C>T	c.(1387-1389)Cgt>Tgt	p.R463C	ZNF280D_ENST00000396245.1_Missense_Mutation_p.R180C|ZNF280D_ENST00000267807.7_Missense_Mutation_p.R476C|ZNF280D_ENST00000559000.1_Missense_Mutation_p.R463C	NM_001002843.1	NP_001002843.1	Q6N043	Z280D_HUMAN	zinc finger protein 280D	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		TTTGTACAACGATGTATTCCT	0.328000													17	66					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187024	123187024	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123187024G>A	ENST00000328880.5	-	1	866	c.807C>T	c.(805-807)taC>taT	p.Y269Y	RP11-324E6.6_ENST00000543611.1_lincRNA|HCAR1_ENST00000356987.2_Intron	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	269					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	CCACCGAGCGGTACACTTCAC	0.552000													7	43					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55569675	55569675	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55569675G>A	ENST00000294383.6	-	42	4898	c.4899C>T	c.(4897-4899)agC>agT	p.S1633S	USP24_ENST00000407756.1_Silent_p.S1473S	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1633					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CTGCCAATCGGCTATTCGCTG	0.348000													7	6					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817311	4817311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4817311G>A	ENST00000248244.5	-	2	1308	c.1079C>T	c.(1078-1080)cCt>cTt	p.P360L		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	360	Pro-rich.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		aggaggaggaggGGATGTTTC	0.542000													21	71					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44013158	44013158	+	Missense_Mutation	SNP	C	C	T	rs144036424		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44013158C>T	ENST00000269439.7	+	2	118	c.67C>T	c.(67-69)Ccc>Tcc	p.P23S	RNF165_ENST00000543885.1_Intron	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	23							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		TCCAGGTGCCCCCTTTCAAAG	0.677000													13	22					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115350393	115350393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115350393C>T	ENST00000369358.4	-	40	5168	c.4924G>A	c.(4924-4926)Gac>Aac	p.D1642N	NRAP_ENST00000360478.3_Missense_Mutation_p.D1599N|NRAP_ENST00000359988.3_Missense_Mutation_p.D1634N|NRAP_ENST00000369360.3_Missense_Mutation_p.D1607N			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1634						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TGCTCCGGGTCGCAGGTGGGC	0.667000													15	52					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34025289	34025289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34025289G>A	ENST00000374372.1	-	3	923	c.420C>T	c.(418-420)gtC>gtT	p.V140V	GDF5_ENST00000374369.3_Silent_p.V140V			P43026	GDF5_HUMAN	growth differentiation factor 5	140					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			AGGAGCTGGGGACAGATCCTG	0.647000													36	84					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31931244	31931244	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31931244C>T	ENST00000375394.2	+	14	1571	c.1458C>T	c.(1456-1458)ccC>ccT	p.P486P	SKIV2L_ENST00000544581.1_Silent_p.P293P	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	486						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						GCCCCGTGCCCCTGGAGCACT	0.562000													18	62					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158583514	158583514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158583514C>T	ENST00000368148.3	-	50	7166	c.6986G>A	c.(6985-6987)gGg>gAg	p.G2329E	SPTA1_ENST00000368147.3_Missense_Mutation_p.G2326E	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2329	EF-hand 2.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTCCTACCTCCCTGGATCCAC	0.493000													35	50					0	0	1	0	0
FUBP3	8939	broad.mit.edu	37	9	133507337	133507337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133507337C>T	ENST00000319725.9	+	15	1436	c.1361C>T	c.(1360-1362)cCt>cTt	p.P454L		NM_003934.1	NP_003925.1	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	454					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		AGTACCTTTCCTCCAAGGAGC	0.602000													26	82					0	0	1	0	0
PRSS54	221191	broad.mit.edu	37	16	58314292	58314292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58314292C>T	ENST00000219301.4	-	7	1418	c.1024G>A	c.(1024-1026)Gaa>Aaa	p.E342K	PRSS54_ENST00000567164.1_Missense_Mutation_p.E342K|PRSS54_ENST00000543437.1_Missense_Mutation_p.E243K|CCDC113_ENST00000219299.4_3'UTR|CCDC113_ENST00000443128.2_3'UTR	NM_001080492.1	NP_001073961.1	Q6PEW0	PRS54_HUMAN	protease, serine, 54	342					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CTGCCTGATTCCTTTACATCC	0.473000													24	70					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102737123	102737123	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102737123G>A	ENST00000532855.1	-	0	1063							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGGCCATAAGGAAGAAATTAA	0.358000													7	15					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165179939	165179939	+	Silent	SNP	C	C	T	rs146395249	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165179939C>T	ENST00000342310.3	-	6	1126	c.744G>A	c.(742-744)gcG>gcA	p.A248A	LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Silent_p.A248A|LMX1A_ENST00000367893.4_Silent_p.A248A|RP11-38C18.2_ENST00000457106.1_RNA	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	248	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					AGGTTACCTTCGCTCTCTGGT	0.473000													20	40					0	0	1	0	0
C1orf222	339457	broad.mit.edu	37	1	1920391	1920391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1920391G>A	ENST00000434971.2	-	3	121	c.89C>T	c.(88-90)cCg>cTg	p.P30L				Q69YW0	CA222_HUMAN	chromosome 1 open reading frame 222	64										breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)	11	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GTCAAACTCCGGATCCTCTAA	0.433000													16	47					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839611	27839611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27839611G>A	ENST00000356790.2	+	3	433	c.188G>A	c.(187-189)gGa>gAa	p.G63E		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	63										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AATCCCCATGGACTTCGGGAA	0.498000													6	8					0	0	1	0	0
CREB3L1	90993	broad.mit.edu	37	11	46342292	46342292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:46342292C>T	ENST00000529193.1	+	12	2007	c.1556C>T	c.(1555-1557)tCc>tTc	p.S519F	CREB3L1_ENST00000288400.3_Missense_Mutation_p.S519F			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	519					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		ATCAAACTCTCCTAGGCCATG	0.592000			T	FUS	myxofibrosarcoma								9	13					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126746129	126746129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:126746129G>A	ENST00000274473.6	+	10	1233	c.966G>A	c.(964-966)gaG>gaA	p.E322E	MEGF10_ENST00000508365.1_Silent_p.E322E|MEGF10_ENST00000418761.2_Silent_p.E322E|MEGF10_ENST00000503335.2_Silent_p.E322E	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	322	EGF-like 6.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TCTGTGCTGAGACCTGCCAGT	0.562000													17	42					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47587925	47587925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47587925G>A	ENST00000172229.3	+	4	845	c.720G>A	c.(718-720)caG>caA	p.Q240Q	NGFR_ENST00000504201.1_Silent_p.Q146Q|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	240	Ser/Thr-rich.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GCAGCTCCCAGCCCGTGGTGA	0.617000													18	50					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76728481	76728481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76728481G>A	ENST00000369950.3	-	7	950	c.761C>T	c.(760-762)tCc>tTc	p.S254F	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	254	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TGGGGACTGGGAGTCAGCGAG	0.537000													9	78					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71977544	71977544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71977544C>T	ENST00000266674.5	+	18	2065	c.1754C>T	c.(1753-1755)tCc>tTc	p.S585F	RP11-186F10.2_ENST00000546601.1_RNA|LGR5_ENST00000540815.2_Missense_Mutation_p.S561F|LGR5_ENST00000536515.1_Missense_Mutation_p.S513F			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	585						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						GTTTTCAGATCCCCTCTGTAC	0.502000													36	117					0	0	1	0	0
KATNAL1	84056	broad.mit.edu	37	13	30801654	30801654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:30801654G>A	ENST00000380615.3	-	9	1209	c.1042C>T	c.(1042-1044)Cct>Tct	p.P348S	KATNAL1_ENST00000380617.3_Missense_Mutation_p.P348S	NM_032116.4	NP_115492.1	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	348						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)|urinary_tract(3)	19		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		ATTTTGGAAGGATCATCATTT	0.358000													10	82					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52708472	52708472	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52708472A>G	ENST00000399231.3	-	5	725	c.482T>C	c.(481-483)gTa>gCa	p.V161A	MYO5A_ENST00000399233.2_Missense_Mutation_p.V161A|MYO5A_ENST00000553916.1_Missense_Mutation_p.V161A|MYO5A_ENST00000356338.6_Missense_Mutation_p.V161A|MYO5A_ENST00000358212.6_Missense_Mutation_p.V161A	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	161	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTCTCCACTTACGATGATGGA	0.423000													31	83					0	0	1	0	0
TAP2	6891	broad.mit.edu	37	6	32782259	32782259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32782259C>T	ENST00000452392.2	-	14	2475	c.2302G>A	c.(2302-2304)Ggg>Agg	p.G768R	HLA-DOB_ENST00000438763.2_Missense_Mutation_p.G161R			Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										TCCTCCTGCCCATTCAGGAAC	0.532000													66	164					0	0	1	0	0
PGC	5225	broad.mit.edu	37	6	41710071	41710071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41710071C>T	ENST00000373025.3	-	5	666	c.604G>A	c.(604-606)Gag>Aag	p.E202K	PGC_ENST00000425343.2_Missense_Mutation_p.E202K	NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	202					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			AGGGCGCCCTCCTGCACCATG	0.642000													33	70					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94703957	94703957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94703957G>A	ENST00000304338.3	+	8	941	c.787G>A	c.(787-789)Gaa>Aaa	p.E263K		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	263						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TTCTAGGGATGAAGGCAGCAG	0.348000													51	134					0	0	1	0	0
FCGR3A	2214	broad.mit.edu	37	1	161514664	161514664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161514664G>A	ENST00000367969.3	-	4	695	c.512C>T	c.(511-513)gCt>gTt	p.A171V	FCGR3A_ENST00000540048.1_Missense_Mutation_p.A135V|FCGR3A_ENST00000436743.1_Missense_Mutation_p.A135V|FCGR3A_ENST00000443193.1_Missense_Mutation_p.A170V	NM_000569.6	NP_000560.5	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	135	Ig-like C2-type 2.				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTTATGCAGAGCAGTGTTCTT	0.483000													16	52					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92590421	92590421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92590421C>T	ENST00000298047.6	+	19	11424	c.11407C>T	c.(11407-11409)Ccg>Tcg	p.P3803S	FAT3_ENST00000525166.1_Missense_Mutation_p.P3653S|FAT3_ENST00000533797.1_Missense_Mutation_p.P138S|FAT3_ENST00000409404.2_Missense_Mutation_p.P3803S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3803	EGF-like 1.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGTGGAGAAGCCGTGTCCAGG	0.557000										TCGA Ovarian(4;0.039)			24	79					0	0	1	0	0
ZNF812	729648	broad.mit.edu	37	19	9801459	9801459	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9801459C>T	ENST00000457674.2	-	5	1238	c.720G>A	c.(718-720)gtG>gtA	p.V240V	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TATGAATTTTCACATGTGCAG	0.333000													27	57					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3731987	3731987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3731987G>A	ENST00000541714.2	+	6	1130	c.668G>A	c.(667-669)gGc>gAc	p.G223D	TJP3_ENST00000589378.1_Missense_Mutation_p.G232D|TJP3_ENST00000539908.2_Missense_Mutation_p.G187D|TJP3_ENST00000262968.9_Missense_Mutation_p.G242D|TJP3_ENST00000382008.3_Missense_Mutation_p.G223D|TJP3_ENST00000587686.1_Missense_Mutation_p.G242D	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	223	PDZ 2.					tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGATTCGGGCCTGGCTGCC	0.597000													16	57					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701183	143701183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143701183C>T	ENST00000408922.2	+	1	162	c.94C>T	c.(94-96)Ctt>Ttt	p.L32F		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TCTGATATTCCTTGTGGCCTA	0.488000													9	50					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74003240	74003240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74003240C>T	ENST00000301607.3	-	22	6299	c.6046G>A	c.(6046-6048)Gag>Aag	p.E2016K	EVPL_ENST00000586740.1_Missense_Mutation_p.E2038K	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	2016	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CGGTACCCCTCCAGTGCCGCT	0.692000													26	49					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	344305	344305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:344305C>T	ENST00000343164.4	-	7	834	c.782G>A	c.(781-783)gGa>gAa	p.G261E	SLC6A13_ENST00000445055.2_Missense_Mutation_p.G169E	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	261					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			AAACTGAATTCCTTGGGCTGC	0.557000													12	69					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56089407	56089407	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56089407C>A	ENST00000257880.7	-	15	2253	c.2034G>T	c.(2032-2034)aaG>aaT	p.K678N	ITGA7_ENST00000347027.6_Missense_Mutation_p.K628N|ITGA7_ENST00000394230.2_Missense_Mutation_p.K638N|ITGA7_ENST00000452168.2_Missense_Mutation_p.K541N|ITGA7_ENST00000553804.1_Missense_Mutation_p.K638N|ITGA7_ENST00000555728.1_Missense_Mutation_p.K678N|ITGA7_ENST00000394229.2_Missense_Mutation_p.K634N|ITGA7_ENST00000257879.6_Missense_Mutation_p.K634N			Q13683	ITA7_HUMAN	integrin, alpha 7	678					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CACAGCCTTGCTTCAGGAAGT	0.572000													20	57					1.10923e-09	1.11347e-09	1	1	0
TACR3	6870	broad.mit.edu	37	4	104511098	104511098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104511098G>A	ENST00000304883.2	-	5	1279	c.1139C>T	c.(1138-1140)tCc>tTc	p.S380F	RP11-297P16.3_ENST00000502936.1_RNA|RP11-297P16.3_ENST00000512401.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	380						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		ATCATAGCTGGAAACTTTGAT	0.453000													19	69					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32812098	32812098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32812098C>T	ENST00000380250.3	+	44	6889	c.6393C>T	c.(6391-6393)tcC>tcT	p.S2131S		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCAAAATATCCATGGTGGATG	0.498000													22	96					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37333917	37333917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37333917G>A	ENST00000262825.5	+	14	2302	c.2085G>A	c.(2083-2085)aaG>aaA	p.K695K	CSF2RB_ENST00000406230.1_Silent_p.K695K|CSF2RB_ENST00000403662.3_Silent_p.K689K|CSF2RB_ENST00000536485.1_Silent_p.K636K	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	689					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	AGGACCAAAAGGACAGCCCTG	0.637000													5	40					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75078455	75078455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75078455G>A	ENST00000326665.5	-	9	1257	c.1039C>T	c.(1039-1041)Ccc>Tcc	p.P347S	C1orf173_ENST00000420661.2_Missense_Mutation_p.P150S|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	347										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AGACTGAAGGGGAAACCATGA	0.413000													20	44					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5042876	5042876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:5042876C>T	ENST00000574788.1	+	22	3635	c.1405C>T	c.(1405-1407)Ccc>Tcc	p.P469S	USP6_ENST00000332776.4_Missense_Mutation_p.P469S|USP6_ENST00000304328.5_Missense_Mutation_p.P152S|USP6_ENST00000250066.6_Missense_Mutation_p.P469S			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	469					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CCCTTGGTTCCCCCATTATGA	0.612000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								24	28					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255668	15255668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15255668G>A	ENST00000378116.4	-	8	1925	c.1919C>T	c.(1918-1920)tCc>tTc	p.S640F		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	640						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GATGGCCTGGGAAGACAGGGG	0.612000													14	56					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32010369	32010369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32010369G>A	ENST00000375244.3	-	40	12274	c.12073C>T	c.(12073-12075)Ccc>Tcc	p.P4025S	TNXB_ENST00000451343.1_Missense_Mutation_p.P454S|TNXB_ENST00000375247.2_Missense_Mutation_p.P4023S			P22105	TENX_HUMAN	tenascin XB	4070	Fibronectin type-III 32.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CTGGGGAAGGGGATCCGCAGC	0.701000													6	10					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154146656	154146656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:154146656G>A	ENST00000389740.2	-	1	848	c.749C>T	c.(748-750)tCc>tTc	p.S250F		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	250						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGGGGACAGGGAAACCACTCT	0.652000													9	54					0	0	1	0	0
DOK2	9046	broad.mit.edu	37	8	21766932	21766932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:21766932C>T	ENST00000276420.4	-	5	1387	c.1129G>A	c.(1129-1131)Gac>Aac	p.D377N	DOK2_ENST00000544659.1_Missense_Mutation_p.D223N	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	377					blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		CCAGCAGGGTCCCTGTCAGCT	0.607000													25	63					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61557763	61557763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61557763G>A	ENST00000290866.4	+	5	745	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	ACE_ENST00000584529.1_3'UTR|ACE_ENST00000428043.1_Missense_Mutation_p.E241K|ACE_ENST00000538928.1_Missense_Mutation_p.E241K	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	241	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGACGATCTGGAACACCTCTA	0.612000													28	75					0	0	1	0	0
FES	2242	broad.mit.edu	37	15	91436511	91436511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91436511C>T	ENST00000394302.1	+	14	1574	c.1489C>T	c.(1489-1491)Cca>Tca	p.P497S	FES_ENST00000450438.2_Intron|FES_ENST00000394300.3_Intron|FES_ENST00000414248.2_Intron|FES_ENST00000328850.3_Intron|FES_ENST00000444422.2_Intron			P07332	FES_HUMAN	feline sarcoma oncogene	631	SH2.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GGGGTCCTCCCCACCTGCAGG	0.692000													7	26					0	0	1	0	0
ATXN2	6311	broad.mit.edu	37	12	111923659	111923659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111923659G>A	ENST00000377617.3	-	17	2956	c.2795C>T	c.(2794-2796)tCt>tTt	p.S932F	ATXN2_ENST00000550104.1_Missense_Mutation_p.S932F|ATXN2_ENST00000542287.2_Missense_Mutation_p.S667F|ATXN2_ENST00000535949.1_Missense_Mutation_p.S643F|ATXN2_ENST00000389153.4_Missense_Mutation_p.S667F	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	932	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						TGGGGTAGTAGAAGGCTTTGG	0.398000													13	38					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146825865	146825865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:146825865C>T	ENST00000361727.3	+	7	1536	c.1020C>T	c.(1018-1020)atC>atT	p.I340I		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	340	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGGAAAGCATCAACTACAATG	0.403000										HNSCC(39;0.1)			48	143					0	0	1	0	0
CAPZA2	830	broad.mit.edu	37	7	116550294	116550294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:116550294C>T	ENST00000361183.2	+	7	653	c.514C>T	c.(514-516)Cgt>Tgt	p.R172C	CAPZA2_ENST00000458284.2_Missense_Mutation_p.S145L	NM_006136.2	NP_006127.1	P47755	CAZA2_HUMAN	capping protein (actin filament) muscle Z-line, alpha 2	172					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex	actin binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	13	all_cancers(3;8.53e-08)|all_epithelial(6;7.79e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)		GBM - Glioblastoma multiforme(2;5.01e-06)|STAD - Stomach adenocarcinoma(10;0.000512)|all cancers(2;0.00326)			AAGGAATGGTCGTTGGAGGTC	0.318000													23	45					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76573717	76573717	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:76573717A>C	ENST00000307431.8	+	21	3704	c.3319A>C	c.(3319-3321)Att>Ctt	p.I1107L	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.I1035L|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.I1059L|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.I1111L|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1108	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CCACATAATGATTAACAGAGA	0.348000													29	87					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85775660	85775660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:85775660C>T	ENST00000405615.2	+	1	29	c.29C>T	c.(28-30)tCc>tTc	p.S10F	CADM2_ENST00000407528.2_Intron|CADM2_ENST00000383699.3_Intron	NM_153184.3	NP_694854.2	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	0					adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TGCAACCTTTCCTTGGTACCA	0.348000													50	144					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32622504	32622504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32622504C>T	ENST00000373625.3	+	3	282	c.189C>T	c.(187-189)ttC>ttT	p.F63F	KPNA6_ENST00000545542.1_Silent_p.F68F|KPNA6_ENST00000537234.1_Silent_p.F60F|KPNA6_ENST00000469790.1_3'UTR	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	63					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTGCCATGTTCGATAGTCTTC	0.453000													30	81					0	0	1	0	0
ZNF778	197320	broad.mit.edu	37	16	89293398	89293398	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89293398C>T	ENST00000433976.2	+	6	950	c.618C>T	c.(616-618)ttC>ttT	p.F206F	RP11-46C24.6_ENST00000563182.1_RNA|ZNF778_ENST00000306502.6_Silent_p.F164F	NM_001201407.1|NM_182531.3	NP_001188336.1|NP_872337.2	Q96MU6	ZN778_HUMAN	zinc finger protein 778	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|skin(2)	24				BRCA - Breast invasive adenocarcinoma(80;0.0269)		GGGAAGTGTTCCTTAATCAGT	0.502000													44	155					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974674	49974674	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49974674G>A	ENST00000555099.1	+	1	732	c.700G>A	c.(700-702)Gcc>Acc	p.A234T		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						AAGGCACGAAGCCCTCTCTAC	0.468000													57	72					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115805519	115805519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:115805519G>A	ENST00000374227.3	-	4	1406	c.1379C>T	c.(1378-1380)cCc>cTc	p.P460L	ZFP37_ENST00000553380.1_Missense_Mutation_p.P475L|ZFP37_ENST00000555206.1_Missense_Mutation_p.P461L			Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	460						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ACATTCAAAGGGTTTCTCACC	0.353000													17	48					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	38997699	38997699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38997699C>T	ENST00000400482.3	-	4	1623	c.1034G>A	c.(1033-1035)gGg>gAg	p.G345E	KCNJ6_ENST00000288309.6_Missense_Mutation_p.G345E	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	345					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	TTCGTAGAACCCGTCCTCCAG	0.557000													7	88					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33623339	33623339	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33623339C>T	ENST00000361680.2	+	1	342	c.264C>T	c.(262-264)gaC>gaT	p.D88D	WDR88_ENST00000355868.3_Silent_p.D88D|WDR88_ENST00000592765.1_Silent_p.D88D			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	88										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					GCGACCAGGACCCTCTCTCCA	0.652000													21	74					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44640909	44640909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44640909G>A	ENST00000372330.3	+	7	1150	c.1131G>A	c.(1129-1131)tcG>tcA	p.S377S		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	377	Fibronectin type-II 3.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CTACCACCTCGAACTTTGACA	0.657000													39	94					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569435	241569435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241569435C>T	ENST00000319838.5	+	6	1008	c.66C>T	c.(64-66)ggC>ggT	p.G22G	GPR35_ENST00000430267.1_Silent_p.G22G|GPR35_ENST00000407714.1_Silent_p.G22G|GPR35_ENST00000403859.1_Silent_p.G22G|GPR35_ENST00000438013.2_Silent_p.G53G	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	22						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		TCAAGCTGGGCTTCTACGCCT	0.647000													31	65					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1064220	1064220	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1064220G>A	ENST00000264930.5	-	19	2628	c.2585C>T	c.(2584-2586)cCc>cTc	p.P862L		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	862					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CAGCAGGAAGGGCAGCAGCAT	0.692000													10	24					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200534713	200534713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200534713G>A	ENST00000367350.4	-	24	4184	c.3746C>T	c.(3745-3747)tCg>tTg	p.S1249L		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	1249	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						AAAATCTAACGAAGAACCAAT	0.323000													30	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579835	179579835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179579835G>A	ENST00000589042.1	-	90	26302	c.26078C>T	c.(26077-26079)tCt>tTt	p.S8693F	TTN_ENST00000342992.6_Missense_Mutation_p.S7449F|TTN_ENST00000591111.1_Missense_Mutation_p.S8376F|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8376	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAGTTCTCAGACATTATCTT	0.453000													88	239					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74593462	74593462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74593462C>T	ENST00000253159.8	+	9	1603	c.1405C>T	c.(1405-1407)Cta>Tta	p.L469L	ZNF236_ENST00000320610.9_Silent_p.L471L	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	469					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GTCACCGTTTCTACCTGGTAA	0.388000													11	32					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133760622	133760622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133760622C>T	ENST00000318560.5	+	11	3326	c.2945C>T	c.(2944-2946)cCc>cTc	p.P982L		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	982	F-actin-binding.|Pro-rich.			P -> PL (in Ref. 1; AAA51561).	actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GCCCCCGTTCCCTCCACGTTG	0.652000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								13	105					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30881934	30881934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:30881934G>A	ENST00000251071.5	-	8	2180	c.1430C>T	c.(1429-1431)cCt>cTt	p.P477L	CAPRIN2_ENST00000308433.5_Missense_Mutation_p.P144L|CAPRIN2_ENST00000538387.1_5'UTR|CAPRIN2_ENST00000395805.2_Missense_Mutation_p.P477L|CAPRIN2_ENST00000298892.5_Missense_Mutation_p.P477L|CAPRIN2_ENST00000417045.1_Missense_Mutation_p.P477L	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	477					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TTTGGATTTAGGTGTATCTTG	0.468000													62	125					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131864581	131864581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131864581C>T	ENST00000359827.3	-	20	4701	c.3739G>A	c.(3739-3741)Ggc>Agc	p.G1247S	PLXNA4_ENST00000321063.4_Missense_Mutation_p.G1247S			Q9HCM2	PLXA4_HUMAN	plexin A4	1247						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						ATGAGGAGGCCGCCAGCCACT	0.617000													11	17					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12760990	12760990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12760990G>A	ENST00000456935.2	-	17	2133	c.2093C>T	c.(2092-2094)tCc>tTc	p.S698F	MAN2B1_ENST00000221363.4_Missense_Mutation_p.S697F	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	698					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AACCACCTGGGAACACCAAGC	0.627000													14	134					0	0	1	0	0
TAAR2	9287	broad.mit.edu	37	6	132938624	132938624	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:132938624G>A	ENST00000275191.2	-	1	693	c.586C>T	c.(586-588)Cat>Tat	p.H196Y	TAAR2_ENST00000367931.1_Missense_Mutation_p.H241Y|TAAR2_ENST00000537809.1_Missense_Mutation_p.H196Y	NM_014626.3	NP_055441.2	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2	241						plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)	23	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		TTGATGGCATGAGCATGTTTT	0.383000													33	47					0	0	1	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117960368	117960368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117960368G>A	ENST00000310164.2	+	4	1668	c.1161G>A	c.(1159-1161)agG>agA	p.R387R		NM_173798.2	NP_776159.1	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	22						AGATGGAGAGGTCAAGAGTGG	0.498000													23	39					0	0	1	0	0
TMEM150B	284417	broad.mit.edu	37	19	55832399	55832399	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55832399C>T	ENST00000326652.4	-	3	188	c.6G>A	c.(4-6)tgG>tgA	p.W2*	TMEM150B_ENST00000438693.1_Nonsense_Mutation_p.W2*			A6NC51	T150B_HUMAN	transmembrane protein 150B	2						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						ACAGGTAGCCCCACATGCCGG	0.602000													11	19					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57257988	57257988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57257988G>A	ENST00000343433.6	-	2	578	c.498C>T	c.(496-498)gcC>gcT	p.A166A	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	166										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CCAGATGGATGGCCTTACTTC	0.483000													50	85					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33703274	33703274	+	Missense_Mutation	SNP	G	G	A	rs143961677	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33703274G>A	ENST00000336934.5	-	5	1656	c.1540C>T	c.(1540-1542)Cat>Tat	p.H514Y	STARD13_ENST00000255486.4_Missense_Mutation_p.H506Y|STARD13_ENST00000399365.3_Missense_Mutation_p.H396Y	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	514					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AATGTATCATGAGTTTGCAGT	0.468000													27	74					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188219	7188219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7188219G>A	ENST00000542285.1	-	11	1728	c.1579C>T	c.(1579-1581)Cct>Tct	p.P527S				P00736	C1R_HUMAN	complement component 1, r subcomponent	579	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCGTTGTCAGGGAGGCAGATG	0.552000													18	31					0	0	1	0	0
BTNL3	10917	broad.mit.edu	37	5	180432608	180432608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180432608C>T	ENST00000342868.6	+	8	1321	c.1137C>T	c.(1135-1137)gtC>gtT	p.V379V		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	379	B30.2/SPRY.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GGTATTGGGTCCTCAGACTGA	0.502000													14	57					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44626787	44626787	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:44626787G>A	ENST00000332990.5	-	5	527	c.511C>T	c.(511-513)Cag>Tag	p.Q171*		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	171						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						TAACCAAACTGAACTTTTCCT	0.468000													6	15					0	0	1	0	0
ZG16B	124220	broad.mit.edu	37	16	2880270	2880270	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2880270G>A	ENST00000382280.3	+	1	101	c.22G>A	c.(22-24)Gag>Aag	p.E8K		NM_145252.2	NP_660295.2	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16B	8						extracellular region	sugar binding			central_nervous_system(1)|lung(2)|ovary(1)|prostate(1)	5						GGGGGCCCAGGAGAGTATAAA	0.677000													8	14					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142612498	142612498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142612498C>T	ENST00000265310.1	-	10	1613	c.1265G>A	c.(1264-1266)gGg>gAg	p.G422E		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	422					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity	p.G422V(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GAATGGCCCCCCAAGAATCGT	0.498000													13	137					0	0	1	0	0
CPSF6	11052	broad.mit.edu	37	12	69652866	69652866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:69652866C>T	ENST00000435070.2	+	6	1301	c.1191C>T	c.(1189-1191)ccC>ccT	p.P397P	CPSF6_ENST00000456847.3_Silent_p.P324P|CPSF6_ENST00000266679.8_Silent_p.P434P|CPSF6_ENST00000551516.1_Intron	NM_007007.2	NP_008938.2	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6, 68kDa	397	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(7)|lung(8)	16	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			ACTATGGCCCCCCTGGAAGGT	0.418000													10	77					0	0	1	0	0
FAM3B	54097	broad.mit.edu	37	21	42694777	42694777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42694777G>A	ENST00000398646.3	+	1	31	c.16G>A	c.(16-18)Ggg>Agg	p.G6R	FAM3B_ENST00000398652.3_Intron|FAM3B_ENST00000479810.2_Intron|FAM3B_ENST00000357985.2_Intron|FAM3B_ENST00000398647.3_Intron			P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	0					apoptosis|insulin secretion	extracellular space	cytokine activity			central_nervous_system(2)|endometrium(1)|lung(2)	5		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				AAGCCACAGGGGGGATGGGGA	0.642000													12	19					0	0	1	0	0
ZNF645	158506	broad.mit.edu	37	X	22292286	22292286	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:22292286G>A	ENST00000323684.1	+	1	1222	c.1178G>A	c.(1177-1179)tGg>tAg	p.W393*		NM_152577.3	NP_689790.1	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	393						intracellular	zinc ion binding			cervix(1)|endometrium(4)|large_intestine(8)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	27						TGGCCTGCATGGAAACGACTG	0.448000													25	39					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120655881	120655881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120655881G>A	ENST00000310396.5	+	3	879	c.412G>A	c.(412-414)Ggg>Agg	p.G138R	CPED1_ENST00000495036.1_3'UTR|CPED1_ENST00000340646.5_Missense_Mutation_p.G138R|CPED1_ENST00000450913.2_Missense_Mutation_p.G138R	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TGCTGGCCTAGGGCCGGGGCT	0.448000													10	25					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31241586	31241586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31241586C>T	ENST00000269197.5	+	5	362	c.362C>T	c.(361-363)tCg>tTg	p.S121L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CTAGTTTGTTCGAAGCAGGTA	0.373000													4	14					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76573658	76573658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:76573658C>T	ENST00000307431.8	+	21	3645	c.3260C>T	c.(3259-3261)cCt>cTt	p.P1087L	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.P1015L|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.P1039L|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.P1091L|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1088	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						TATCAAGAGCCTGATGTTGTT	0.348000													14	50					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003386	75003386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:75003386C>T	ENST00000373359.2	-	1	1693	c.1501G>A	c.(1501-1503)Gag>Aag	p.E501K		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	501	MAGE 2.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCCACAGCCTCCCTATATTGT	0.488000													30	16					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105923959	105923959	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105923959G>A	ENST00000357060.3	-	24	3254	c.3139C>T	c.(3139-3141)Cga>Tga	p.R1047*	WDR96_ENST00000428666.1_Nonsense_Mutation_p.R1048*	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1047								p.R1047*(1)		NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCTCGAATTCGAACATTTCTT	0.368000													12	31					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111057732	111057732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111057732C>T	ENST00000551590.1	+	2	468	c.312C>T	c.(310-312)gtC>gtT	p.V104V	TCTN1_ENST00000397655.3_Silent_p.V104V|TCTN1_ENST00000471804.2_Silent_p.V104V|TCTN1_ENST00000377654.3_5'UTR|TCTN1_ENST00000550703.2_Silent_p.V104V|TCTN1_ENST00000551555.2_3'UTR|TCTN1_ENST00000397659.4_Silent_p.V104V			Q2MV58	TECT1_HUMAN	tectonic family member 1	104					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						ATTTCAGTGTCTTTTCTGCCT	0.438000													38	113					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51503798	51503798	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51503798C>T	ENST00000600767.1	-	4	601	c.112G>A	c.(112-114)Gag>Aag	p.E38K	KLK8_ENST00000291726.7_Missense_Mutation_p.E38K|CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000593490.1_Intron|KLK8_ENST00000347619.4_Intron|KLK8_ENST00000391806.2_Missense_Mutation_p.E83K|KLK8_ENST00000320838.5_Intron			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	38	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GGTTGGCACTCATGACCCCCC	0.637000													30	83					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62818111	62818111	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62818111C>T	ENST00000582986.1	-	0	387					NR_024386.1																						TGATGGACTTCGATGTCTTCA	0.562000													17	36					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166959042	166959042	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:166959042G>A	ENST00000367872.4	+	2	445	c.201G>A	c.(199-201)aaG>aaA	p.K67K	MAEL_ENST00000367870.2_Intron	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	67					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						CTCAGGGAAAGGACCCTGGGC	0.502000													13	29					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28877987	28877987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28877987C>T	ENST00000337120.5	+	1	3863	c.572C>T	c.(571-573)cCc>cTc	p.P191L	SH2B1_ENST00000545570.1_Intron|SH2B1_ENST00000359285.5_Missense_Mutation_p.P191L|SH2B1_ENST00000322610.8_Missense_Mutation_p.P191L|SH2B1_ENST00000538342.1_Intron|SH2B1_ENST00000395532.4_Missense_Mutation_p.P191L|SH2B1_ENST00000563674.1_Intron	NM_001145812.1|NM_015503.2	NP_001139284.1|NP_056318.2	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	191	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Interaction with RAC1 (By similarity).|Required for NGF signaling (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						TCGTCAGGCCCCCCAGTCTTA	0.657000													7	85					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32183144	32183144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32183144G>A	ENST00000375023.3	-	12	2018	c.1880C>T	c.(1879-1881)cCc>cTc	p.P627L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	627	EGF-like 16.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						AGCACACAGGGGAACCTCACA	0.557000													6	17					0	0	1	0	0
TAL2	6887	broad.mit.edu	37	9	108425072	108425072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:108425072C>T	ENST00000334077.3	+	1	335	c.295C>T	c.(295-297)Cct>Tct	p.P99S		NM_005421.2	NP_005412.1	Q16559	TAL2_HUMAN	T-cell acute lymphocytic leukemia 2	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding										CTACCAGGTTCCTTCACCTGG	0.572000			T	TRB@	T-ALL								8	21					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160094107	160094107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160094107G>A	ENST00000361216.3	+	6	606	c.517G>A	c.(517-519)Gga>Aga	p.G173R	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Missense_Mutation_p.G173R	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	173					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GATCCGGGAGGGAGAGAAGAT	0.597000													7	14					0	0	1	0	0
WDR91	29062	broad.mit.edu	37	7	134890719	134890719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:134890719G>A	ENST00000354475.4	-	5	717	c.686C>T	c.(685-687)cCt>cTt	p.P229L	WDR91_ENST00000485942.1_5'UTR|WDR91_ENST00000423565.1_Missense_Mutation_p.P194L|WDR91_ENST00000344400.5_Missense_Mutation_p.P229L	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	229										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						GGAGACATAAGGAGGCAATTT	0.522000													55	161					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180036981	180036981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180036981G>A	ENST00000261937.6	-	28	3809	c.3731C>T	c.(3730-3732)gCt>gTt	p.A1244V	FLT4_ENST00000393347.3_Missense_Mutation_p.A1244V|FLT4_ENST00000502649.1_Missense_Mutation_p.A1244V	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1244					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity	p.A1244V(2)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACGGGTCTCAGCCCCTCTGGC	0.572000													47	130					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38913777	38913777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38913777C>T	ENST00000302328.3	-	20	3600	c.3402G>A	c.(3400-3402)gtG>gtA	p.V1134V	SCN11A_ENST00000456224.3_Silent_p.V1096V|SCN11A_ENST00000444237.2_Silent_p.V1134V|SCN11A_ENST00000450244.1_Silent_p.V1134V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1134					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGAGGGTGGTCACAGAGACCT	0.473000													27	87					0	0	1	0	0
BRS3	680	broad.mit.edu	37	X	135574322	135574322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135574322C>T	ENST00000370648.3	+	3	1216	c.988C>T	c.(988-990)Ctc>Ttc	p.L330F		NM_001727.1	NP_001718.1	P32247	BRS3_HUMAN	bombesin-like receptor 3	330					adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(1)	23	Acute lymphoblastic leukemia(192;0.000127)					CCCCTTTGCTCTCTACTGGCT	0.478000													106	73					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134385	128134385	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:128134385G>A	ENST00000368250.1	-	5	1662	c.1164C>T	c.(1162-1164)tcC>tcT	p.S388S	THEMIS_ENST00000368248.2_Silent_p.S467S|THEMIS_ENST00000543064.1_Silent_p.S467S|THEMIS_ENST00000537166.1_Silent_p.S432S			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	467	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						CCTCTTCAATGGAAAGATCCC	0.473000													32	35					0	0	1	0	0
DEFB110	245913	broad.mit.edu	37	6	49989596	49989596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49989596G>A	ENST00000371148.2	-	1	98	c.53C>T	c.(52-54)cCa>cTa	p.P18L	DEFB110_ENST00000393660.2_Missense_Mutation_p.P18L	NM_001037497.1	NP_001032586.1	Q30KQ9	DB110_HUMAN	defensin, beta 110 locus	18					defense response to bacterium	extracellular region				endometrium(1)|lung(1)|ovary(1)	3	Lung NSC(77;0.042)					CATATTACCTGGTAAAATTGT	0.303000													14	50					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49001503	49001503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49001503C>T	ENST00000600059.1	-	11	3050	c.2823G>A	c.(2821-2823)gaG>gaA	p.E941E	LMTK3_ENST00000270238.3_Silent_p.E970E					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CCGCCGCCTTCTCCTCGATGC	0.642000													8	94					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23299694	23299694	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23299694G>A	ENST00000560464.1	-	0	4496																											GGAGTAGGCGGCATCATCCAT	0.592000													8	44					0	0	1	0	0
MICU3	286097	broad.mit.edu	37	8	16921710	16921710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16921710G>A	ENST00000318063.5	+	2	541	c.499G>A	c.(499-501)Gat>Aat	p.D167N		NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		GACTCCGTATGATTTTATTTT	0.348000													16	91					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168310314	168310314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168310314C>T	ENST00000519560.1	-	5	860	c.441G>A	c.(439-441)ggG>ggA	p.G147G	SLIT3_ENST00000332966.8_Silent_p.G147G|SLIT3_ENST00000404867.3_Silent_p.G147G	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	147					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTCGGGATCCCCTGGATCT	0.468000													15	46					0	0	1	0	0
ACTA1	58	broad.mit.edu	37	1	229568553	229568553	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:229568553G>A	ENST00000366684.3	-	3	306	c.204C>T	c.(202-204)acC>acT	p.T68T	ACTA1_ENST00000366683.2_Silent_p.T68T	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	68			T -> I (in NEM3).		muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GGTACTTCAGGGTCAGGATAC	0.582000													31	82					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45009349	45009349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:45009349G>A	ENST00000258787.7	-	11	1594	c.1458C>T	c.(1456-1458)acC>acT	p.T486T		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	486	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						GCATGTCCAGGGTCTGCAGGA	0.662000													45	110					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58131029	58131029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58131029C>T	ENST00000547588.1	-	1	1000	c.1001G>A	c.(1000-1002)gGg>gAg	p.G334E	AGAP2_ENST00000257897.3_Intron	NM_001122772.2	NP_001116244.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	334	Interaction with PLCG1 (By similarity).				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						TGCTCGGCCCCCCTCCCGGCC	0.677000													5	18					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24776027	24776027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24776027G>A	ENST00000221166.5	+	3	3441	c.2659G>A	c.(2659-2661)Gaa>Aaa	p.E887K	NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000433454.2_Missense_Mutation_p.E511K|NEFM_ENST00000437366.2_Missense_Mutation_p.E848K|NEFM_ENST00000518131.1_Missense_Mutation_p.E669K			P07197	NFM_HUMAN	neurofilament, medium polypeptide	887	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TGAAGAGCATGAAGAGACCTT	0.423000													48	105					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42154381	42154381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42154381G>A	ENST00000320955.6	-	44	7722	c.7495C>T	c.(7495-7497)Cct>Tct	p.P2499S		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2499					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GGGCTGCGAGGAGCGGGGCTC	0.622000													6	17					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7324365	7324365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7324365C>T	ENST00000318881.6	+	2	478	c.241C>T	c.(241-243)Ccg>Tcg	p.P81S	SYT9_ENST00000396716.2_Missense_Mutation_p.P49S	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	81						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CTGCTGGGTTCCGTGGCGAGA	0.542000													41	86					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165956930	165956930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165956930G>A	ENST00000360093.3	-	22	4339	c.3848C>T	c.(3847-3849)tCt>tTt	p.S1283F	SCN3A_ENST00000283254.7_Missense_Mutation_p.S1283F|SCN3A_ENST00000409101.3_Missense_Mutation_p.S1234F	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1283						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.S1283F(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GCTAACCAAAGAAACCTACAA	0.373000													7	34					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100754	8100754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:8100754C>T	ENST00000379328.3	+	3	1296	c.728C>T	c.(727-729)tCc>tTc	p.S243F	GATA3_ENST00000346208.3_Missense_Mutation_p.S243F|GATA3_ENST00000461472.1_3'UTR	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	243					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CTGGGCGGCTCCCCCACCGGC	0.672000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						20	44					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9017450	9017450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9017450G>A	ENST00000397910.4	-	26	38077	c.37874C>T	c.(37873-37875)cCt>cTt	p.P12625L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12627	SEA 4.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCCACTCCAGGGCTTTTGGG	0.572000													11	160					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81472121	81472121	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81472121G>A	ENST00000548058.1	+	1	1132	c.222G>A	c.(220-222)gaG>gaA	p.E74E	ACSS3_ENST00000261206.3_Silent_p.E74E			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	74						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CCGACCCCGAGAGGTTCTGGG	0.647000													6	64					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575371	136575371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136575371G>A	ENST00000264162.2	-	6	1257	c.1247C>T	c.(1246-1248)cCc>cTc	p.P416L		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	416	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGTGTTCAGGGGCCTGCGTGG	0.652000													46	85					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750032	142750032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142750032C>T	ENST00000418316.1	+	1	616	c.595C>T	c.(595-597)Ctg>Ttg	p.L199L		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					CTGGGACTTTCTGATGGCCTT	0.532000													72	153					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76787359	76787359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76787359C>T	ENST00000286719.7	-	15	2259	c.1903G>A	c.(1903-1905)Gaa>Aaa	p.E635K		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	635					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTCAGTTGTTCCTTGGCCAAG	0.498000													56	120					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407248	38407248	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38407248G>A	ENST00000322350.5	+	8	1493	c.1147_splice	c.e8+1	p.D383_splice	EGFLAM_ENST00000336740.6_Splice_Site_p.D149_splice|EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000354891.3_Splice_Site_p.D383_splice	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	383						cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					CTGCTCAGAAGGTAGGCCCTT	0.547000													12	30					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233150438	233150438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233150438C>T	ENST00000258229.8	-	28	5159	c.4925G>A	c.(4924-4926)gGa>gAa	p.G1642E	PCNXL2_ENST00000344698.2_Missense_Mutation_p.G294E	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1642						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGCGGCTGTTCCCAGAGCTCT	0.527000													23	61					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56088753	56088753	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56088753C>T	ENST00000257880.7	-	16	2356	c.2135_splice	c.e16-1	p.D713_splice	ITGA7_ENST00000347027.6_Splice_Site_p.D663_splice|ITGA7_ENST00000394230.2_Splice_Site_p.D673_splice|ITGA7_ENST00000452168.2_Splice_Site_p.D576_splice|ITGA7_ENST00000553804.1_Splice_Site_p.D673_splice|ITGA7_ENST00000555728.1_Splice_Site_p.D713_splice|ITGA7_ENST00000394229.2_Splice_Site_p.D669_splice|ITGA7_ENST00000257879.6_Splice_Site_p.D669_splice			Q13683	ITA7_HUMAN	integrin, alpha 7	713					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCATCCACATCCCTGGAGAGT	0.612000													14	29					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99170840	99170840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99170840C>T	ENST00000074304.5	+	16	1862	c.1469C>T	c.(1468-1470)tCg>tTg	p.S490L	INPP4A_ENST00000409463.1_Intron|INPP4A_ENST00000409016.3_Missense_Mutation_p.S490L|INPP4A_ENST00000545415.1_Missense_Mutation_p.S490L|INPP4A_ENST00000409540.3_Missense_Mutation_p.S490L|INPP4A_ENST00000409851.3_Missense_Mutation_p.S485L|INPP4A_ENST00000523221.1_Missense_Mutation_p.S490L	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	490					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						TCTCCCACTTCGACTGAGGAG	0.602000													9	20					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049412	70049412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70049412C>T	ENST00000330891.5	-	10	1508	c.1282G>A	c.(1282-1284)Gac>Aac	p.D428N	BEST3_ENST00000488961.1_Missense_Mutation_p.D215N|BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Missense_Mutation_p.D322N	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	428						chloride channel complex|plasma membrane	chloride channel activity	p.D428N(1)|p.D215N(1)		cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GGGCTGAGGTCATCTCGGGGT	0.592000													25	90					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31091248	31091248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31091248C>T	ENST00000332585.6	+	1	456	c.352C>T	c.(352-354)Ccc>Tcc	p.P118S	OSBP2_ENST00000407373.1_Intron|OSBP2_ENST00000382310.3_Missense_Mutation_p.P118S|OSBP2_ENST00000403222.3_Intron|OSBP2_ENST00000446658.2_Missense_Mutation_p.P118S	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	118					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						AGGGGCTGGGCCCTTCACTAA	0.687000													27	49					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115161063	115161063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115161063C>T	ENST00000393274.1	-	8	1893	c.1268G>A	c.(1267-1269)gGg>gAg	p.G423E	DENND2C_ENST00000393277.1_Missense_Mutation_p.G423E|DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Missense_Mutation_p.G366E	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	423										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCTTCTTCCCTCTTTTAGA	0.343000													20	72					0	0	1	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862124	25862124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25862124G>A	ENST00000397060.4	-	4	546	c.437C>T	c.(436-438)tCt>tTt	p.S146F	SLC17A3_ENST00000361703.6_Intron|SLC17A3_ENST00000360657.3_Intron	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	290					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						TGCAAACAAAGAAATGCCAAC	0.483000													6	15					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75167505	75167505	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:75167505G>A	ENST00000336926.6	-	31	3128	c.3102C>T	c.(3100-3102)acC>acT	p.T1034T	HIP1_ENST00000434438.2_Silent_p.T983T	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	1034					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						ATTCTTTTTCGGTTACCACTT	0.418000			T	PDGFRB	CMML								10	200					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140984946	140984946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140984946C>T	ENST00000298296.1	+	7	1402	c.1402C>T	c.(1402-1404)Ctc>Ttc	p.L468F	MAGEC3_ENST00000536088.1_Missense_Mutation_p.L170F|MAGEC3_ENST00000544766.1_Missense_Mutation_p.L170F|MAGEC3_ENST00000409007.1_Missense_Mutation_p.L170F|MAGEC3_ENST00000443323.2_Missense_Mutation_p.L90F	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	468	MAGE 2.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					GCAGTTTCTTCTCCTCAAATA	0.463000													33	23					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6125769	6125769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6125769C>T	ENST00000261405.5	-	30	5478	c.5224G>A	c.(5224-5226)Gac>Aac	p.D1742N		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1742	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CATGGCACGTCAATGGTGGTG	0.542000													30	49					0	0	1	0	0
RP11-166N6.3	0	broad.mit.edu	37	3	150659371	150659371	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:150659371G>A	ENST00000569170.1	-	1	159	c.160C>T	c.(160-162)Cag>Tag	p.Q54*	CLRN1_ENST00000327047.1_Missense_Mutation_p.S144L|RP11-166N6.2_ENST00000469268.1_RNA|CLRN1_ENST00000295911.2_Missense_Mutation_p.S68L|CLRN1_ENST00000328863.4_Missense_Mutation_p.S144L|CLRN1-AS1_ENST00000476886.1_RNA																							GTACTTACCTGAAATGAAGCT	0.363000													16	57					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31532917	31532917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31532917G>A	ENST00000215885.3	-	5	1428	c.1176C>T	c.(1174-1176)ctC>ctT	p.L392L		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	392					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						TGCAGTGGAAGAGGGGCTCTT	0.687000													6	19					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313818	54313818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54313818G>A	ENST00000324134.6	-	3	1263	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	NLRP12_ENST00000354278.3_Silent_p.F365F|NLRP12_ENST00000391772.1_Silent_p.F365F|NLRP12_ENST00000351894.4_Silent_p.F365F|NLRP12_ENST00000391775.3_Silent_p.F365F|NLRP12_ENST00000535162.1_Silent_p.F365F|NLRP12_ENST00000345770.5_Silent_p.F365F|NLRP12_ENST00000391773.1_Silent_p.F365F	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	365	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTGCCTCAGAGAAGCCCAGGA	0.542000													90	226					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110466714	110466714	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110466714C>T	ENST00000329608.6	+	6	1862	c.1471C>T	c.(1471-1473)Ccg>Tcg	p.P491S	CSF1_ENST00000369801.1_Missense_Mutation_p.P375S|CSF1_ENST00000344188.5_Missense_Mutation_p.P375S|CSF1_ENST00000369802.3_Missense_Mutation_p.P491S|CSF1_ENST00000420111.2_Missense_Mutation_p.P193S	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	491					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		ATCCTTCAGCCCGCAGCTCCA	0.622000													36	66					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502084	90502084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90502084C>T	ENST00000325643.5	+	4	2748	c.2682C>T	c.(2680-2682)ttC>ttT	p.F894F		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		TTCCCATTTTCCTGGGAAAAC	0.597000													6	33					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57330048	57330048	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57330048A>T	ENST00000326441.9	-	8	1055	c.692T>A	c.(691-693)gTg>gAg	p.V231E	ZIM2_ENST00000221722.5_Missense_Mutation_p.V106E|ZIM2_ENST00000601070.1_Missense_Mutation_p.V106E|ZIM2_ENST00000599935.1_Missense_Mutation_p.V106E|PEG3_ENST00000598410.1_Missense_Mutation_p.V106E|PEG3_ENST00000593695.1_Missense_Mutation_p.V105E|ZIM2_ENST00000593711.1_Missense_Mutation_p.V106E|ZIM2_ENST00000391708.3_Missense_Mutation_p.V106E|PEG3_ENST00000423103.2_Missense_Mutation_p.V231E	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	231					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GAGGTCCACCACATTTTGGTA	0.478000													30	84					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35506332	35506332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35506332G>A	ENST00000217320.3	+	2	108	c.64G>A	c.(64-66)Gag>Aag	p.E22K	TLDC2_ENST00000602922.1_Missense_Mutation_p.E22K	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		CCTGTCTggggaggagggtaa	0.622000													10	76					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47278193	47278193	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47278193G>A	ENST00000271153.4	+	4	429	c.393G>A	c.(391-393)ggG>ggA	p.G131G	CYP4B1_ENST00000371923.4_Silent_p.G131G|CYP4B1_ENST00000371919.4_Silent_p.G116G|CYP4B1_ENST00000452782.2_5'UTR			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	131					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TTCTTGAGGGGCCCAAGTGGT	0.587000													11	25					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143013383	143013383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143013383C>T	ENST00000343257.2	+	1	165	c.78C>T	c.(76-78)ccC>ccT	p.P26P		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	26					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					AGTATATGCCCTTTGAACACT	0.637000													30	147					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100268916	100268916	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100268916C>T	ENST00000515683.1	-	0	457				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	ATGCGAACTTCATGAGCCTTA	0.338000													22	57					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150932029	150932029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:150932029G>A	ENST00000309170.3	-	3	388	c.76C>T	c.(76-78)Cct>Tct	p.P26S	P2RY14_ENST00000424796.2_Missense_Mutation_p.P26S|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	26						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TACAGCACAGGAATGATCTGC	0.458000													35	107					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9045590	9045590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9045590G>A	ENST00000397910.4	-	5	36244	c.36041C>T	c.(36040-36042)gCc>gTc	p.A12014V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12016	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTCTCAGAGGCCAAGGTGGA	0.403000													5	10					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99917408	99917408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99917408G>A	ENST00000332397.6	+	9	1751	c.1567G>A	c.(1567-1569)Gtt>Att	p.V523I	SPDYE3_ENST00000437326.2_Missense_Mutation_p.V146I	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	523										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						CAGGGCTTGGGTTTCCCCGGA	0.632000													19	75					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940775	22940775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22940775C>T	ENST00000397104.3	-	5	1662	c.1663G>A	c.(1663-1665)Gag>Aag	p.E555K	ZNF99_ENST00000596209.1_Missense_Mutation_p.E646K					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TAGGGTTTCTCTCCAGTATGA	0.368000													24	65					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45744123	45744123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:45744123G>A	ENST00000297323.7	+	17	2747	c.2725G>A	c.(2725-2727)Gaa>Aaa	p.E909K		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	909					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	AAAGCTCATGGAAAAAGACTT	0.502000													30	82					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897906	175897906	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175897906G>A	ENST00000359240.3	+	5	1900	c.1230G>A	c.(1228-1230)gaG>gaA	p.E410E	ADAM29_ENST00000445694.1_Silent_p.E410E|ADAM29_ENST00000404450.4_Silent_p.E410E|ADAM29_ENST00000514159.1_Silent_p.E410E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	410	Disintegrin.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AAGGAGAAGAGTGTGACTGTG	0.428000													32	107					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36875124	36875124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36875124C>T	ENST00000301807.6	-	21	6065	c.4168G>A	c.(4168-4170)Gac>Aac	p.D1390N	TRANK1_ENST00000429976.2_Missense_Mutation_p.D1940N|TRANK1_ENST00000428977.2_Missense_Mutation_p.D1390N	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1940					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAGTCCTTGTCGGCAGTGAGC	0.587000													10	27					0	0	1	0	0
VSIG1	340547	broad.mit.edu	37	X	107310234	107310234	+	Silent	SNP	C	C	T	rs138849840	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107310234C>T	ENST00000415430.3	+	4	551	c.390C>T	c.(388-390)aaC>aaT	p.N130N	VSIG1_ENST00000217957.5_Silent_p.N94N|VSIG1_ENST00000485533.1_3'UTR	NM_001170553.1	NP_001164024.1	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	94	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17						CAGGGTCCAACGATCCAGGTA	0.438000													6	61					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41550202	41550202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41550202C>T	ENST00000396942.1	-	31	3905	c.3822G>A	c.(3820-3822)gaG>gaA	p.E1274E	ANK1_ENST00000289734.7_Silent_p.E1274E|ANK1_ENST00000347528.4_Silent_p.E1274E|ANK1_ENST00000379758.2_Silent_p.E1274E|ANK1_ENST00000352337.4_Silent_p.E1274E|ANK1_ENST00000265709.8_Silent_p.E1315E|ANK1_ENST00000396945.1_Silent_p.E1274E			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1274					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCACGAAGTTCTCATGCTGCT	0.577000													114	326					0	0	1	0	0
C11orf70	85016	broad.mit.edu	37	11	101951951	101951951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101951951G>A	ENST00000434758.2	+	6	642	c.614G>A	c.(613-615)cGa>cAa	p.R205Q	C11orf70_ENST00000526781.1_Missense_Mutation_p.R205Q	NM_032930.2	NP_116319.2	Q9BRQ4	CK070_HUMAN	chromosome 11 open reading frame 70	205										breast(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|skin(2)	12	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		TTTAGTGTTCGAAAGAATCCT	0.299000													16	59					0	0	1	0	0
MSANTD2	79684	broad.mit.edu	37	11	124637768	124637768	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124637768G>A	ENST00000526629.1	-	3	1741	c.294C>T	c.(292-294)atC>atT	p.I98I	MSANTD2_ENST00000374979.3_Silent_p.I328I|MSANTD2_ENST00000524950.1_3'UTR|MSANTD2_ENST00000239614.4_Silent_p.I276I			Q6P1R3	CK061_HUMAN	Myb/SANT-like DNA-binding domain containing 2	328																	AATGGTAACGGATATCCTCTT	0.468000													40	118					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13830182	13830182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13830182C>T	ENST00000265104.4	-	37	6306	c.6202G>A	c.(6202-6204)Gga>Aga	p.G2068R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2068	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ACATTATCTCCATCAGTAAAG	0.378000									Kartagener syndrome				14	49					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540207	169540207	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169540207G>A	ENST00000340806.6	+	1	498	c.498G>A	c.(496-498)aaG>aaA	p.K166K		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	166										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ACCAGACCAAGCTGAGGGAGA	0.493000													13	98					0	0	1	0	0
CHRDL1	91851	broad.mit.edu	37	X	109924794	109924794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:109924794C>T	ENST00000218054.4	-	10	1262	c.1066G>A	c.(1066-1068)Gag>Aag	p.E356K	CHRDL1_ENST00000434224.1_Missense_Mutation_p.E277K|CHRDL1_ENST00000372045.1_Missense_Mutation_p.E350K|CHRDL1_ENST00000482160.1_Missense_Mutation_p.E278K|CHRDL1_ENST00000372042.1_Missense_Mutation_p.E358K|CHRDL1_ENST00000444321.2_Missense_Mutation_p.E357K|CHRDL1_ENST00000394797.4_Missense_Mutation_p.E356K	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	350					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						TCCCCATCCTCCATGAATACA	0.473000													72	39					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38843566	38843566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38843566C>T	ENST00000359357.3	+	51	7423	c.7169C>T	c.(7168-7170)tCa>tTa	p.S2390L	DNAH8_ENST00000441566.1_Missense_Mutation_p.S2354L|DNAH8_ENST00000449981.2_Missense_Mutation_p.S2607L					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CCTAAAGGCTCAAATCAAACC	0.358000													20	56					0	0	1	0	0
PTHLH	5744	broad.mit.edu	37	12	28116336	28116336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:28116336G>A	ENST00000535992.1	-	3	815	c.469C>T	c.(469-471)Cta>Tta	p.L157L	PTHLH_ENST00000539239.1_Silent_p.L157L|PTHLH_ENST00000538310.1_Silent_p.L157L|PTHLH_ENST00000395872.1_Silent_p.L157L|PTHLH_ENST00000395868.3_Silent_p.L157L|RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000354417.3_Silent_p.L157L|PTHLH_ENST00000545234.1_Silent_p.L157L|PTHLH_ENST00000201015.4_Silent_p.L157L			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	157					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					TCCCCTTCTAGCCCACTCCCA	0.572000													24	55					0	0	1	0	0
TAB1	10454	broad.mit.edu	37	22	39824183	39824183	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39824183C>T	ENST00000216160.6	+	10	1364	c.1302C>T	c.(1300-1302)ctC>ctT	p.L434L	TAB1_ENST00000331454.3_Silent_p.L434L	NM_006116.2	NP_006107.1	Q15750	TAB1_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 1	434					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|urinary_tract(1)	14						CCCCCACCCTCACCAAGTAAG	0.637000													14	50					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189849638	189849638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189849638G>A	ENST00000304636.3	+	2	402	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	COL3A1_ENST00000317840.5_Missense_Mutation_p.E78K	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	78	VWFC.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCCCAACCCAGAAATTCCATT	0.418000													16	65					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42459061	42459061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42459061G>A	ENST00000318006.5	-	14	1590	c.1428C>T	c.(1426-1428)tgC>tgT	p.C476C	VPS39_ENST00000348544.4_Silent_p.C487C	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	487					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		CCTCGATGTGGCAGTGATTGT	0.552000													47	104					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262033	45262033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:45262033G>A	ENST00000303230.4	-	8	2720	c.2663C>T	c.(2662-2664)tCa>tTa	p.S888L		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	888						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TCATAAATTTGAAGCAAATCG	0.438000													37	173					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88584281	88584281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88584281G>A	ENST00000339673.6	+	6	1450	c.1351G>A	c.(1351-1353)Gaa>Aaa	p.E451K	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.E435K|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	451					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CCATTCTGAGGAAGACGACAG	0.532000													7	59					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367630	107367630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107367630G>A	ENST00000542196.1	-	1	321	c.279C>T	c.(277-279)tcC>tcT	p.S93S		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						AGCCAGAAAGGGAAATGGTCT	0.517000													26	99					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74347431	74347431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:74347431G>A	ENST00000377044.4	-	7	1938	c.1399C>T	c.(1399-1401)Cct>Tct	p.P467S	TMEM2_ENST00000377066.5_Missense_Mutation_p.P404S	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	467						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AGGAACTGAGGGGTTTCTGGT	0.408000													22	34					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85434298	85434298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:85434298C>T	ENST00000393217.2	+	3	224	c.163C>T	c.(163-165)Cac>Tac	p.H55Y		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	55										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		ATCAGTTCTTCACTGTATTAA	0.303000													23	92					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70942322	70942322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70942322C>T	ENST00000357250.6	-	36	2625	c.2467G>A	c.(2467-2469)Ggg>Agg	p.G823R	COL9A1_ENST00000370499.4_Missense_Mutation_p.G580R|COL9A1_ENST00000489611.1_5'UTR|RP1-149L1.1_ENST00000522264.1_RNA|COL9A1_ENST00000320755.7_Missense_Mutation_p.G580R	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	823	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CCAGGGGGCCCCTTAATGCCC	0.552000													12	141					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086691	100086691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100086691C>T	ENST00000423930.1	+	4	1506	c.1347C>T	c.(1345-1347)ctC>ctT	p.L449L	NYAP1_ENST00000454988.1_Silent_p.L392L|NYAP1_ENST00000300179.2_Silent_p.L449L			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	449	Pro-rich.																ccgccTTGCTCCCCGGCCCCC	0.721000													3	6					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	134980913	134980913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134980913C>T	ENST00000304613.3	+	2	152	c.131C>T	c.(130-132)tCc>tTc	p.S44F	KNDC1_ENST00000368572.2_Missense_Mutation_p.S44F|KNDC1_ENST00000530127.1_3'UTR|KNDC1_ENST00000368571.2_5'UTR			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	44	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GACATCCTCTCCCTGCGGGAC	0.711000													3	4					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228175562	228175562	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228175562G>A	ENST00000396578.3	+	51	4988	c.4826G>A	c.(4825-4827)cGa>cAa	p.R1609Q	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1609	Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GAAGAATTCCGAGCCAGCCCA	0.463000													19	83					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139429023	139429023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:139429023C>T	ENST00000272641.3	-	2	370	c.264G>A	c.(262-264)acG>acA	p.T88T		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	88	II.				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		CCTGAATCTCCGTGATGTTGG	0.483000													76	41					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072407	9072407	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9072407C>T	ENST00000397910.4	-	3	15242	c.15039G>A	c.(15037-15039)ttG>ttA	p.L5013L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5015	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTCACATCCAATTGTGAAA	0.483000													21	58					0	0	1	0	0
MRM1	79922	broad.mit.edu	37	17	34964690	34964690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34964690C>T	ENST00000250156.7	+	5	1140	c.901C>T	c.(901-903)Cac>Tac	p.H301Y	MRM1_ENST00000585770.1_Missense_Mutation_p.H106Y	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	301					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		AATTCTTCTTCACTCCATTTG	0.542000													81	106					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40717020	40717020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40717020C>T	ENST00000298910.7	+	38	5626	c.5568C>T	c.(5566-5568)gcC>gcT	p.A1856A		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1856					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTCAGATTGCCCCTGACTTGA	0.338000													25	69					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24579067	24579067	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24579067G>A	ENST00000358321.3	+	2	380	c.119G>A	c.(118-120)gGg>gAg	p.G40E		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	40	SMB.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						GCCCTGGACGGGCCATGTTCC	0.632000													18	182					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30139662	30139662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30139662G>A	ENST00000376694.4	+	7	1403	c.934G>A	c.(934-936)Gac>Aac	p.D312N	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	312	B30.2/SPRY.				mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						TCTCTCGGAAGACAGGAAGTC	0.652000													5	14					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105168911	105168911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105168911G>A	ENST00000428173.2	+	19	3506	c.3203G>A	c.(3202-3204)cGa>cAa	p.R1068Q	NRK_ENST00000243300.9_Missense_Mutation_p.R1067Q			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1067							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						GGAGTCGTTCGAACCAGTGAA	0.493000										HNSCC(51;0.14)			36	18					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233394686	233394686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233394686G>A	ENST00000536614.1	+	6	575	c.547G>A	c.(547-549)Ggt>Agt	p.G183S	CHRND_ENST00000457943.2_Intron|CHRND_ENST00000258385.3_Silent_p.R219R|CHRND_ENST00000543200.1_Silent_p.R204R			Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	498					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GGCCGGCCAGGGTCAACGTGG	0.642000													19	101					0	0	1	0	0
OR10H3	26532	broad.mit.edu	37	19	15852698	15852698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15852698C>T	ENST00000305892.1	+	1	496	c.496C>T	c.(496-498)Cac>Tac	p.H166Y		NM_013938.1	NP_039226.1	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H, member 3	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						GATGGTTTTTCACCTCACTTT	0.502000													46	98					0	0	1	0	0
FAM98A	25940	broad.mit.edu	37	2	33810711	33810711	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33810711G>A	ENST00000403368.1	-	7	843	c.774C>T	c.(772-774)tcC>tcT	p.S258S	FAM98A_ENST00000238823.8_Silent_p.S258S|FAM98A_ENST00000441530.2_Silent_p.S63S	NM_015475.3	NP_056290.3	Q8NCA5	FA98A_HUMAN	family with sequence similarity 98, member A	259										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(1)	24	all_hematologic(175;0.115)					TAGTTTTAGGGGATAAGACTG	0.398000													35	102					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89266243	89266243	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89266243G>A	ENST00000464162.1	-	0	43																											GCTGAGCGGGGACCCTCATGT	0.577000													35	183					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922679	24922679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922679C>T	ENST00000329468.2	+	1	2139	c.1665C>T	c.(1663-1665)tcC>tcT	p.S555S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1									p.S555S(1)									CAGTCATTTCCACTGTCACAA	0.488000													40	139					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21422680	21422680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21422680C>T	ENST00000307378.6	-	16	2535	c.1815G>A	c.(1813-1815)ccG>ccA	p.P605P	SLCO1A2_ENST00000452078.1_Silent_p.P605P|SLCO1A2_ENST00000537524.1_Silent_p.P473P|SLCO1A2_ENST00000458504.1_Silent_p.P473P	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	605					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						TTAGTGCTGCCGGCAATCCGA	0.343000													30	102					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44253805	44253805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44253805C>T	ENST00000371505.4	-	3	864	c.742G>A	c.(742-744)Gat>Aat	p.D248N	TCTE1_ENST00000371504.1_Missense_Mutation_p.D95N|TMEM151B_ENST00000438774.2_Intron|TCTE1_ENST00000371503.3_Missense_Mutation_p.D95N	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	248										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCCTTGACATCGTACACCAGG	0.592000													21	67					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153431388	153431388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153431388C>T	ENST00000368723.3	-	2	212	c.102G>A	c.(100-102)acG>acA	p.T34T	S100A7_ENST00000368722.1_Silent_p.T34T	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	34	EF-hand 1.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCTTCATCATCGTCAGCAGGC	0.468000													48	139					0	0	1	0	0
BTN1A1	696	broad.mit.edu	37	6	26509185	26509185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26509185C>T	ENST00000244513.6	+	7	1430	c.1364C>T	c.(1363-1365)cCc>cTc	p.P455L		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	455	B30.2/SPRY.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						TTCTCTGGCCCCCTCCGGCCC	0.478000													18	71					0	0	1	0	0
SLC35F1	222553	broad.mit.edu	37	6	118588247	118588247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:118588247C>T	ENST00000360388.4	+	4	768	c.567C>T	c.(565-567)atC>atT	p.I189I		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	189					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		TCATCGGCATCGTTGTCTGCA	0.532000													94	160					0	0	1	0	0
EFNA4	1945	broad.mit.edu	37	1	155039326	155039326	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155039326G>A	ENST00000368409.3	+	2	327	c.234G>A	c.(232-234)gtG>gtA	p.V78V	EFNA3_ENST00000556931.1_Intron|EFNA3_ENST00000505139.1_Intron|EFNA4_ENST00000427683.2_Silent_p.V78V|EFNA4_ENST00000359751.4_Silent_p.V78V	NM_005227.2	NP_005218.1			ephrin-A4											breast(1)|endometrium(1)|large_intestine(1)|ovary(1)	4	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TGTACATGGTGGACTGGCCAG	0.612000													20	43					0	0	1	0	0
TTC25	83538	broad.mit.edu	37	17	40091482	40091482	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40091482C>T	ENST00000591658.1	+	0	195							Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25							cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				TCTTTACCTTCAGGATGGAGA	0.537000													11	24					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987943	50987943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50987943G>A	ENST00000395676.2	+	1	1482	c.1348G>A	c.(1348-1350)Ggg>Agg	p.G450R		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	450										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGCCTGCCGTGGGGACATCTA	0.672000													32	77					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374055	31374055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31374055C>T	ENST00000268296.4	+	12	1461	c.1340C>T	c.(1339-1341)gCc>gTc	p.A447V	ITGAX_ENST00000562522.1_Missense_Mutation_p.A447V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	447					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						AGGATGAAGGCCGAAGTCACG	0.647000													12	35					0	0	1	0	0
HAT1	8520	broad.mit.edu	37	2	172803273	172803273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:172803273C>T	ENST00000264108.4	+	3	194	c.158C>T	c.(157-159)cCt>cTt	p.P53L	SLC25A12_ENST00000472748.1_Intron|HAT1_ENST00000392584.1_Intron	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	53					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			ACTTTCTTTCCTGAGTATACC	0.279000													29	99					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203017798	203017798	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203017798C>T	ENST00000367240.2	+	11	1839	c.1312C>T	c.(1312-1314)Ctg>Ttg	p.L438L	PPFIA4_ENST00000414050.2_Silent_p.L145L|PPFIA4_ENST00000447715.2_Silent_p.L442L|PPFIA4_ENST00000295706.4_5'UTR			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	132					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CAACGAGCGTCTGCAGCTCCA	0.652000													4	22					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71155355	71155355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71155355C>T	ENST00000283228.2	-	4	975	c.523G>A	c.(523-525)Gga>Aga	p.G175R	PTPRR_ENST00000342084.4_Missense_Mutation_p.G63R	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	175					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TCAGAAATTCCTGTTTTTCGG	0.343000													34	137					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57719769	57719769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57719769G>A	ENST00000333493.4	+	11	1632	c.1471G>A	c.(1471-1473)Ggg>Agg	p.G491R	GPR97_ENST00000327655.6_Missense_Mutation_p.G281R|RP11-405F3.4_ENST00000563062.1_RNA|GPR97_ENST00000450388.3_Missense_Mutation_p.G371R	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	491					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TGTGACATGGGGGTTGGCCAT	0.617000													22	54					0	0	1	0	0
ASPHD2	57168	broad.mit.edu	37	22	26830241	26830241	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26830241G>A	ENST00000215906.5	+	2	1098	c.660G>A	c.(658-660)atG>atA	p.M220I		NM_020437.4	NP_065170.2	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	220					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	16						GATGGAAAATGAACAGCACCC	0.532000													20	61					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13423582	13423582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13423582G>A	ENST00000360228.5	-	12	1568	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F	CACNA1A_ENST00000573710.2_Silent_p.F524F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	524					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CTAAGAAAATGAATTCTGCAT	0.458000													11	38					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154744764	154744764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154744764G>A	ENST00000271915.3	-	3	1450	c.1135C>T	c.(1135-1137)Cct>Tct	p.P379S	KCNN3_ENST00000358505.2_Missense_Mutation_p.P66S|KCNN3_ENST00000361147.4_Missense_Mutation_p.P74S	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	384						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TACTCGCCAGGAATGGGGTGG	0.597000													8	30					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101759873	101759873	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:101759873G>A	ENST00000251127.6	-	22	2625	c.2544C>T	c.(2542-2544)aaC>aaT	p.N848N		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	848						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCCGGCAAAAGTTTCTGAACC	0.502000													18	93					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87487623	87487623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87487623G>A	ENST00000327946.7	-	10	1607	c.1522C>T	c.(1522-1524)Ctc>Ttc	p.L508F	GRID1_ENST00000536331.1_Missense_Mutation_p.L79F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	508						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TTGCTGATGAGCTCCCCGATC	0.537000										Multiple Myeloma(13;0.14)			17	70					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969464	47969464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47969464C>T	ENST00000236877.6	-	2	592	c.197G>A	c.(196-198)gGt>gAt	p.G66D	SLC8A2_ENST00000539381.1_Intron|SLC8A2_ENST00000542837.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	66					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CGCCTTGTCACCCAGCGACGG	0.657000													14	48					0	0	1	0	0
SLC20A1	6574	broad.mit.edu	37	2	113416991	113416991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113416991C>T	ENST00000272542.3	+	8	1798	c.1259C>T	c.(1258-1260)tCc>tTc	p.S420F		NM_005415.4	NP_005406.3	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate transporter), member 1	420					phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|skin(1)|urinary_tract(3)	28						AGCTATACTTCCTATACCATG	0.463000													31	80					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29104781	29104781	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29104781G>A	ENST00000261590.8	+	8	1153	c.944G>A	c.(943-945)gGa>gAa	p.G315E		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	315	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TTTGCATCAGGAAATGAAGGA	0.373000													12	81					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344390	56344390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56344390C>T	ENST00000526812.2	-	1	873	c.808G>A	c.(808-810)Gag>Aag	p.E270K		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						ATTTTGGACTCCTCTACAGAC	0.423000													64	192					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47682051	47682051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47682051G>A	ENST00000283303.2	+	6	1328	c.1070G>A	c.(1069-1071)aGg>aAg	p.R357K	GPR115_ENST00000371220.1_Missense_Mutation_p.R414K|GPR115_ENST00000327753.3_Missense_Mutation_p.R357K	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	357	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						TCCAAGAAAAGGAGATGGGAT	0.448000													21	65					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6954416	6954416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:6954416G>A	ENST00000383032.1	+	16	1885	c.1238G>A	c.(1237-1239)gGg>gAg	p.G413E	TBL1Y_ENST00000346432.3_Missense_Mutation_p.G413E|TBL1Y_ENST00000355162.2_Missense_Mutation_p.G413E	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	413					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						AGCCCCACCGGGCCTGCCACC	0.537000													13	13					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032457	30032457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30032457G>A	ENST00000328224.6	-	2	3002	c.1769C>T	c.(1768-1770)cCc>cTc	p.P590L		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	590						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CAAATTAGAGGGGAGGTATGG	0.433000													18	46					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149002610	149002610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:149002610C>T	ENST00000355292.3	-	9	3214	c.2852G>A	c.(2851-2853)cGa>cAa	p.R951Q	NR3C2_ENST00000344721.4_Missense_Mutation_p.R947Q|NR3C2_ENST00000342437.4_3'UTR|NR3C2_ENST00000511528.1_Missense_Mutation_p.R951Q|NR3C2_ENST00000512865.1_Missense_Mutation_p.R830Q|NR3C2_ENST00000358102.3_Missense_Mutation_p.R947Q			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	947	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ATGGGACTCTCGGAAGGTGTA	0.602000													21	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575645	179575645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179575645C>T	ENST00000589042.1	-	98	28403	c.28179G>A	c.(28177-28179)ggG>ggA	p.G9393G	TTN_ENST00000342992.6_Silent_p.G8149G|TTN_ENST00000591111.1_Silent_p.G9076G|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9076	Ig-like 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGGTTCTTCCCCTCTAATA	0.453000													24	58					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27135420	27135420	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27135420G>A	ENST00000343060.4	-	1	173	c.112C>T	c.(112-114)Cag>Tag	p.Q38*	HOTAIRM1_ENST00000495032.1_RNA|HOXA1_ENST00000355633.5_Nonsense_Mutation_p.Q38*	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	38						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GCGCACGACTGGAAAGTTGTA	0.617000											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	46	109					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102495961	102495961	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102495961G>A	ENST00000260228.2	-	1	102	c.90C>T	c.(88-90)tcC>tcT	p.S30S	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	30					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AGGTCCTGGGGGAGGCTGCAA	0.532000													18	75					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703087	4703087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4703087G>A	ENST00000396950.3	-	2	1094	c.855C>T	c.(853-855)gtC>gtT	p.V285V		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGGATTGATGACAGGAGGCA	0.512000													22	47					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247608109	247608109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247608109C>T	ENST00000366497.2	+	8	3606	c.2826C>T	c.(2824-2826)ctC>ctT	p.L942L	NLRP3_ENST00000391828.3_Silent_p.L999L|NLRP3_ENST00000336119.3_Silent_p.L999L|NLRP3_ENST00000391827.2_Silent_p.L942L|NLRP3_ENST00000348069.2_Silent_p.L885L|NLRP3_ENST00000366496.2_Silent_p.L942L	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	999					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGAGCTGCCTCCTGCAGAACC	0.567000													5	47					0	0	1	0	0
ZNF557	79230	broad.mit.edu	37	19	7076403	7076403	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7076403C>T	ENST00000414706.1	+	5	605	c.132C>T	c.(130-132)acC>acT	p.T44T	ZNF557_ENST00000439035.2_Silent_p.T37T|ZNF557_ENST00000252840.6_Silent_p.T44T	NM_001044387.1|NM_001044388.1|NM_024341.2	NP_001037852.1|NP_001037853.1|NP_077317.2	Q8N988	ZN557_HUMAN	zinc finger protein 557	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17				Lung(535;0.179)		GCTTGGTGACCTTTGAGGATG	0.582000													45	111					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24181469	24181469	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24181469G>A	ENST00000265769.4	+	9	953	c.843G>A	c.(841-843)ggG>ggA	p.G281G	ADAM28_ENST00000437154.2_Silent_p.G281G|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_Silent_p.G28G|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_Silent_p.G48G|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000518516.1_3'UTR	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	281	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AATGGAGGGGGAGTGTTCTCT	0.398000													32	72					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488233	24488233	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:24488233T>G	ENST00000264463.4	-	12	2413	c.1906A>C	c.(1906-1908)Aga>Cga	p.R636R	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	636					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TTTCGCTGTCTTTTCAGAGCT	0.393000										HNSCC(23;0.051)			24	55					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81110911	81110911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81110911C>T	ENST00000228644.3	+	1	221	c.69C>T	c.(67-69)tcC>tcT	p.S23S		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	23					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						GCATACCGTCCCCCGAGGGTG	0.617000													26	28					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99658619	99658619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:99658619C>T	ENST00000373034.4	-	2	3866	c.2191G>A	c.(2191-2193)Gga>Aga	p.G731R	PCDH19_ENST00000255531.7_Intron|PCDH19_ENST00000420881.2_Intron	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	731					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CTGTTTTGTCCTTTTATAAAA	0.428000													8	4					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	114141190	114141190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:114141190G>A	ENST00000276198.1	+	6	1317	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	HTR2C_ENST00000371951.1_Missense_Mutation_p.E197K|HTR2C_ENST00000371950.3_Missense_Mutation_p.R165Q	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	197					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	ACTGAGGGACGAAGAAAAGGT	0.443000													23	90					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110717531	110717531	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110717531C>T	ENST00000331565.4	+	5	1187	c.702C>T	c.(700-702)gcC>gcT	p.A234A		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	234					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TCCTCGTGGCCTGGAGCATCG	0.602000													23	43					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22025612	22025612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:22025612G>A	ENST00000261200.4	-	16	2144	c.2145C>T	c.(2143-2145)ctC>ctT	p.L715L	ABCC9_ENST00000261201.4_Silent_p.L715L|ABCC9_ENST00000345162.2_Silent_p.L679L|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	715	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGATGGCAAGGAGAAGAGAGG	0.423000													77	172					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088494	94088494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94088494C>T	ENST00000553484.1	+	31	5135	c.4981C>T	c.(4981-4983)Cct>Tct	p.P1661S	UNC79_ENST00000555664.1_Missense_Mutation_p.P1639S|UNC79_ENST00000256339.4_Missense_Mutation_p.P1462S|UNC79_ENST00000393151.2_Missense_Mutation_p.P1639S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1639						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GCCTCTTCCCCCTCTCAGAAT	0.517000													35	113					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447415	24447415	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24447415G>A	ENST00000270800.1	-	7	1643	c.1605C>T	c.(1603-1605)tcC>tcT	p.S535S		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	535						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GACACACAAGGGACTCCAGCA	0.612000													6	76					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739233	38739233	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38739233C>T	ENST00000449082.2	-	27	5477	c.5478G>A	c.(5476-5478)gaG>gaA	p.E1826E		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1826					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TAAACTTCTCCTCCATATTTG	0.428000													19	91					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41515243	41515243	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41515243C>T	ENST00000324071.4	+	5	772	c.765C>T	c.(763-765)acC>acT	p.T255T	CYP2B6_ENST00000330446.5_Intron|CYP2B6_ENST00000593831.1_Intron	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	255					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ACCGTGAAACCCTGGACCCCA	0.542000													42	93					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413290	124413290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124413290C>T	ENST00000306842.2	-	1	285	c.261G>A	c.(259-261)agG>agA	p.R87R		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		TGATGTTCTTCCTTGAGACAA	0.433000													24	81					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332847	70332847	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70332847C>T	ENST00000338508.4	-	32	3553	c.3554G>A	c.(3553-3555)aGc>aAc	p.S1185N	SHANK2_ENST00000423696.2_Missense_Mutation_p.S805N|SHANK2_ENST00000409161.1_Missense_Mutation_p.S588N|SHANK2_ENST00000449833.2_Missense_Mutation_p.S589N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	805					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGCTGGGCTGCTCTCGGGCCC	0.692000													26	63					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74825629	74825629	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:74825629C>T	ENST00000358399.3	+	4	504	c.411C>T	c.(409-411)acC>acT	p.T137T	GDA_ENST00000238018.4_Silent_p.T137T|GDA_ENST00000376986.1_Silent_p.T95T|GDA_ENST00000376989.3_Silent_p.T112T|GDA_ENST00000477618.1_3'UTR|GDA_ENST00000545168.1_Silent_p.T63T	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	137					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		ATGGAACAACCACAGCTTGTT	0.418000													11	51					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31611188	31611188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31611188G>A	ENST00000170150.3	+	16	1571	c.1376G>A	c.(1375-1377)tGa>tAa	p.*459*		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	0						extracellular region	lipid binding										TACCAGAGCTGAGGCAAGACC	0.567000													9	58					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857232	9857232	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9857232G>A	ENST00000396573.2	-	14	4478	c.4169C>T	c.(4168-4170)tCg>tTg	p.S1390L	GRIN2A_ENST00000535259.1_Missense_Mutation_p.R1119C|GRIN2A_ENST00000404927.2_Missense_Mutation_p.R1276C|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R1276C|GRIN2A_ENST00000330684.3_Missense_Mutation_p.S1390L|GRIN2A_ENST00000396575.2_Missense_Mutation_p.S1390L	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1390					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGATGGCAACGAGTGTTTGTA	0.552000													17	67					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29627145	29627145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29627145G>A	ENST00000376894.4	+	2	256	c.138G>A	c.(136-138)ggG>ggA	p.G46G	MOG_ENST00000376898.3_Silent_p.G46G|MOG_ENST00000494692.1_Silent_p.G46G|MOG_ENST00000376891.4_Silent_p.G46G|MOG_ENST00000376902.3_Silent_p.G46G|MOG_ENST00000490427.1_Intron|MOG_ENST00000376888.2_Intron|MOG_ENST00000483013.1_Intron|MOG_ENST00000469603.1_3'UTR|MOG_ENST00000416766.2_Silent_p.G46G|MOG_ENST00000431798.2_Silent_p.G46G|MOG_ENST00000533330.2_Silent_p.G46G|MOG_ENST00000376917.3_Silent_p.G46G|MOG_ENST00000396701.2_Silent_p.G46G|MOG_ENST00000396704.3_Silent_p.G46G			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	46	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						CTCTGGTCGGGGATGAAGTGG	0.547000													59	200					0	0	1	0	0
FLYWCH2	114984	broad.mit.edu	37	16	2946512	2946512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2946512C>T	ENST00000396958.3	+	3	442	c.62C>T	c.(61-63)tCc>tTc	p.S21F	FLYWCH2_ENST00000293981.6_Missense_Mutation_p.S21F|FLYWCH2_ENST00000572006.1_Missense_Mutation_p.S21F	NM_001142500.1|NM_138439.2	NP_001135972.1|NP_612448.1	Q96CP2	FWCH2_HUMAN	FLYWCH family member 2	21										central_nervous_system(1)|lung(3)|ovary(1)|skin(1)	6						CAGGAGCCATCCCCCAAGCCA	0.652000													15	82					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17046493	17046493	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17046493G>A	ENST00000492551.1	-	0	159					NR_026567.1																						CTCAGGGAGGGGAAGTCTCCT	0.632000													13	153					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68641181	68641181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68641181G>A	ENST00000423218.2	-	10	1213	c.1118C>T	c.(1117-1119)tCg>tTg	p.S373L	ITGA11_ENST00000315757.7_Missense_Mutation_p.S373L			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	373					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	CACCACGTGCGAGGAAAAGCC	0.567000													6	15					0	0	1	0	0
CALB1	793	broad.mit.edu	37	8	91075654	91075654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:91075654C>T	ENST00000265431.3	-	7	667	c.486G>A	c.(484-486)ctG>ctA	p.L162L	CALB1_ENST00000518457.1_Silent_p.L105L	NM_004929.2	NP_004920.1	P05937	CALB1_HUMAN	calbindin 1, 28kDa	162	EF-hand 4.					nucleus	calcium ion binding|vitamin D binding			breast(1)|kidney(1)|lung(8)|pancreas(1)	11			BRCA - Breast invasive adenocarcinoma(11;0.00953)			CAGTTAATTCCAGCTTCCCAT	0.313000													12	51					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50225432	50225432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50225432G>A	ENST00000002829.3	+	19	2726	c.2242G>A	c.(2242-2244)Ggt>Agt	p.G748S	SEMA3F_ENST00000413852.1_Missense_Mutation_p.G649S|SEMA3F_ENST00000434342.1_Missense_Mutation_p.G717S	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	748					axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		GTACTGCCAGGGTTACTGGCG	0.701000													9	14					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51887531	51887531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51887531G>A	ENST00000453097.2	+	20	2961	c.2744G>A	c.(2743-2745)gGa>gAa	p.G915E	SLC4A8_ENST00000358657.3_Missense_Mutation_p.G942E	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	915					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		CTTTACATGGGAGTTTCTTCA	0.443000													33	169					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345534	92345534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:92345534C>T	ENST00000377067.3	+	3	791	c.419C>T	c.(418-420)tCg>tTg	p.S140L		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	140						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GCTGCTGCTTCGGTTCAGGAG	0.408000													94	105					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85970858	85970858	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85970858C>T	ENST00000372117.3	+	13	1525	c.1422C>T	c.(1420-1422)tcC>tcT	p.S474S	CDHR1_ENST00000332904.3_Silent_p.S474S|CDHR1_ENST00000440770.2_Intron	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	474	Cadherin 5.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						AGTTCGACTCCCTCTACTACG	0.582000													40	90					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106772153	106772153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:106772153C>T	ENST00000228347.4	+	8	827	c.605C>T	c.(604-606)tCa>tTa	p.S202L	POLR3B_ENST00000539066.1_Missense_Mutation_p.S144L	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	202					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						GTTGGAGCTTCAGTTACCAGG	0.408000													50	102					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44387268	44387268	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44387268T>A	ENST00000371477.3	+	9	1474	c.1175T>A	c.(1174-1176)tTc>tAc	p.F392Y		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	392	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAGAGTGACTTCTCAGGTGTA	0.428000													36	95					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161162403	161162403	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161162403C>T	ENST00000308192.9	+	17	2142	c.2079C>T	c.(2077-2079)gtC>gtT	p.V693V		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	693	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATTATGTGGTCGCTGACCGGA	0.473000													24	39					0	0	1	0	0
RPAP2	79871	broad.mit.edu	37	1	92798992	92798992	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92798992G>A	ENST00000370343.3	+	9	1609	c.1500G>A	c.(1498-1500)caG>caA	p.Q500Q		NM_024813.2	NP_079089.2	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	500						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	22		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		CCCAGAACCAGATTAGAAAAC	0.328000													14	78					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110031617	110031617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110031617C>T	ENST00000369870.3	+	7	947	c.932C>T	c.(931-933)tCc>tTc	p.S311F		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	311										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		GAGCGCCCCTCCCAGGAGCTC	0.617000													16	47					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150842649	150842649	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150842649C>T	ENST00000370357.4	+	15	2411	c.2166C>T	c.(2164-2166)acC>acT	p.T722T		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	722						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GCCAACCCACCTACCATCAGG	0.567000													36	52					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416279	178416279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178416279G>A	ENST00000231188.5	-	5	1318	c.1140C>T	c.(1138-1140)acC>acT	p.T380T	GRM6_ENST00000517717.1_Silent_p.T380T|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	380					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TGCATTTGCGGGTGGAATCGT	0.617000													10	46					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53666508	53666508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53666508C>T	ENST00000257934.4	+	6	1464	c.1373C>T	c.(1372-1374)tCt>tTt	p.S458F	ESPL1_ENST00000552462.1_Missense_Mutation_p.S458F	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	458					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CCTGCAGCTTCTTACACCAGT	0.537000													128	389					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113084920	113084920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113084920C>T	ENST00000393845.2	-	19	2747	c.2681G>A	c.(2680-2682)aGg>aAg	p.R894K	WDR52_ENST00000295868.2_Missense_Mutation_p.R894K	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	894										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						CATGTCTTTCCTTAGCATAAA	0.303000													44	129					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147016541	147016541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147016541G>A	ENST00000265272.5	-	11	2068	c.1601C>T	c.(1600-1602)gCt>gTt	p.A534V	JAKMIP2_ENST00000507386.1_Missense_Mutation_p.A534V|JAKMIP2_ENST00000333010.6_Missense_Mutation_p.A492V	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	534						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTTTCTGAGCCAGAGTCGC	0.502000													27	254					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10894144	10894144	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:10894144G>A	ENST00000283141.6	+	3	419	c.123G>A	c.(121-123)caG>caA	p.Q41Q	SYCP2L_ENST00000543878.1_5'UTR|RP11-637O19.3_ENST00000480294.1_3'UTR	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	41						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			AAGGATTTCAGAAAATAAAAG	0.308000													4	30					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228473972	228473972	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228473972G>A	ENST00000570156.2	+	39	10559	c.10485G>A	c.(10483-10485)cgG>cgA	p.R3495R	OBSCN_ENST00000366707.4_Silent_p.R185R|OBSCN_ENST00000422127.1_Silent_p.R3066R|OBSCN_ENST00000284548.11_Silent_p.R3066R|OBSCN_ENST00000366709.4_Silent_p.R185R|OBSCN_ENST00000359599.6_Silent_p.R1913R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2528	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGACCCTGCGGCAGCTGGCGC	0.657000													3	8					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112705447	112705447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112705447G>A	ENST00000448454.2	+	8	984	c.984G>A	c.(982-984)acG>acA	p.T328T	PALM2_ENST00000374531.2_Silent_p.T294T|PALM2-AKAP2_ENST00000302798.7_Intron|PALM2-AKAP2_ENST00000374530.3_Intron|AKAP2_ENST00000555236.1_Intron|AKAP2_ENST00000510514.5_Intron|PALM2_ENST00000314527.4_Silent_p.T326T|PALM2_ENST00000483909.1_Silent_p.T292T					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						AAGAGGAGACGAAAAAGGTGC	0.502000													34	82					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922879	24922879	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922879C>T	ENST00000329468.2	+	1	2339	c.1865C>T	c.(1864-1866)tCc>tTc	p.S622F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GTCTACACATCCCCACTTCCA	0.483000													40	80					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22263514	22263514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:22263514C>T	ENST00000379374.4	+	21	2700	c.2135C>T	c.(2134-2136)cCc>cTc	p.P712L	PHEX_ENST00000535894.1_Missense_Mutation_p.P615L|PHEX_ENST00000537599.1_Intron|PHEX_ENST00000418858.3_Missense_Mutation_p.P415L	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	712					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						GCTCACAGTCCCCCTCAGTTT	0.502000													18	96					0	0	1	0	0
AGA	175	broad.mit.edu	37	4	178358631	178358631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:178358631G>A	ENST00000264595.2	-	5	677	c.550C>T	c.(550-552)Cca>Tca	p.P184S	AGA_ENST00000506853.1_5'UTR	NM_000027.3|NM_001171988.1	NP_000018.2|NP_001165459.1	P20933	ASPG_HUMAN	aspartylglucosaminidase	184					asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|skin(2)	16		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		ATACCAGGTGGTTTGTAGGGT	0.348000													13	26					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98545880	98545880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98545880C>T	ENST00000359863.4	+	33	4773	c.4564C>T	c.(4564-4566)Cat>Tat	p.H1522Y	TRRAP_ENST00000355540.3_Missense_Mutation_p.H1504Y|TRRAP_ENST00000446306.3_Missense_Mutation_p.H1503Y	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1522					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAACCTTTTTCATCTGATCCC	0.438000													38	74					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30976046	30976046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:30976046G>A	ENST00000295055.8	-	10	1136	c.960C>T	c.(958-960)ttC>ttT	p.F320F	CAPN13_ENST00000534090.2_Silent_p.F320F	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	320	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					ATTTCTGTTGGAAATCTTGAC	0.448000													30	97					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54965696	54965696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54965696C>T	ENST00000326764.5	+	6	993	c.514C>T	c.(514-516)Ccc>Tcc	p.P172S	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	135							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GCCCTCAAATCCCCCACATGG	0.682000													21	23					0	0	1	0	0
VRK3	51231	broad.mit.edu	37	19	50511003	50511003	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50511003G>A	ENST00000599538.1	-	5	1034	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	VRK3_ENST00000377011.2_Nonsense_Mutation_p.Q74*|VRK3_ENST00000593919.1_Nonsense_Mutation_p.Q124*|VRK3_ENST00000601341.1_Nonsense_Mutation_p.Q74*|VRK3_ENST00000601912.1_Nonsense_Mutation_p.Q74*|VRK3_ENST00000443401.2_5'UTR|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000316763.3_Nonsense_Mutation_p.Q124*|VRK3_ENST00000594092.1_Nonsense_Mutation_p.Q124*|VRK3_ENST00000594948.1_Nonsense_Mutation_p.Q124*			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	124						nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		CTGGTCTTCTGAGGGCTACCC	0.602000													34	121					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46343634	46343634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:46343634G>A	ENST00000256413.3	+	10	1709	c.1414G>A	c.(1414-1416)Gag>Aag	p.E472K	CTIF_ENST00000382998.4_Missense_Mutation_p.E474K	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	472	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						GCAGGACGTGGAGCGCTGGCT	0.672000													19	87					0	0	1	0	0
NOLC1	9221	broad.mit.edu	37	10	103912198	103912198	+	Missense_Mutation	SNP	C	C	T	rs145813353		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103912198C>T	ENST00000405356.1	+	1	266	c.31C>T	c.(31-33)Ccc>Tcc	p.P11S	NOLC1_ENST00000603742.1_5'UTR|NOLC1_ENST00000488254.2_Missense_Mutation_p.P11S|NOLC1_ENST00000605788.1_Missense_Mutation_p.P11S			Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	11	LisH.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		CCGCGTGGTTCCCAGCGACCT	0.622000													14	114					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886395	3886395	+	Missense_Mutation	SNP	G	G	A	rs140162397		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3886395G>A	ENST00000319331.3	+	2	831	c.70G>A	c.(70-72)Gag>Aag	p.E24K	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	24						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TTCATTAACCGAGTCTTCCAT	0.473000													6	77					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14765924	14765924	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14765924C>T	ENST00000253673.5	-	6	547	c.447G>A	c.(445-447)tgG>tgA	p.W149*	EMR3_ENST00000599900.1_Intron|EMR3_ENST00000344373.4_Nonsense_Mutation_p.W97*|EMR3_ENST00000443157.2_Intron	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	149					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						CTTCTGTTCTCCATAAAGTCT	0.368000													14	101					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71125438	71125438	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71125438C>T	ENST00000299213.8	-	3	499	c.429G>A	c.(427-429)cgG>cgA	p.R143R		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	143	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						TTCTCCAGTCCCGTGTAAGAT	0.483000													24	80					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70919657	70919657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70919657C>T	ENST00000264436.3	-	7	1027	c.583G>A	c.(583-585)Gtg>Atg	p.V195M	ADD2_ENST00000413157.2_Missense_Mutation_p.V195M|ADD2_ENST00000407644.2_Missense_Mutation_p.V195M|ADD2_ENST00000355733.3_Missense_Mutation_p.V195M|ADD2_ENST00000430656.1_Missense_Mutation_p.V211M	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	195					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CCCTTCTCCACCACCTCTCCC	0.617000													14	33					0	0	1	0	0
KLHL5	51088	broad.mit.edu	37	4	39082836	39082836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39082836C>T	ENST00000261425.3	+	4	832	c.680C>T	c.(679-681)tCc>tTc	p.S227F	KLHL5_ENST00000359687.2_Missense_Mutation_p.S273F|KLHL5_ENST00000381930.3_Missense_Mutation_p.S273F|KLHL5_ENST00000508137.2_Missense_Mutation_p.S86F|KLHL5_ENST00000504108.1_Missense_Mutation_p.S273F|KLHL5_ENST00000261426.5_Missense_Mutation_p.S212F	NM_001007075.2	NP_001007076.1	Q96PQ7	KLHL5_HUMAN	kelch-like family member 5	273	BTB.					cytoplasm|cytoskeleton	actin binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29						TCGTTGTGGTCCTTGATCCAG	0.333000													29	64					0	0	1	0	0
ACTA2	59	broad.mit.edu	37	10	90695041	90695041	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90695041C>T	ENST00000458208.1	-	9	1547	c.1073G>A	c.(1072-1074)tGg>tAg	p.W358*	ACTA2-AS1_ENST00000437930.3_RNA|STAMBPL1_ENST00000371927.3_Intron|ACTA2_ENST00000224784.6_Nonsense_Mutation_p.W358*	NM_001141945.1	NP_001135417.1	P62736	ACTA_HUMAN	actin, alpha 2, smooth muscle, aorta	358					response to virus	cytosol	ATP binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(2)	17		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TTTGCTGATCCACATCTGCTG	0.517000											OREG0020356	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	148					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122377072	122377072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122377072G>A	ENST00000334010.7	-	2	811	c.390C>T	c.(388-390)ctC>ctT	p.L130L	CADPS2_ENST00000313070.7_Silent_p.L130L|CADPS2_ENST00000449022.2_Silent_p.L130L|CADPS2_ENST00000412584.2_Silent_p.L130L	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	130					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						TTTCCCCATTGAGGAAGGCCT	0.398000													17	29					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55294968	55294968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55294968G>A	ENST00000336077.6	+	7	888	c.848G>A	c.(847-849)gGa>gAa	p.G283E	KIR2DL1_ENST00000291633.7_Missense_Mutation_p.G309E|KIR3DL1_ENST00000541392.1_Intron|KIR2DL3_ENST00000434419.2_Missense_Mutation_p.G283E|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL4_ENST00000396284.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	283					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		GAGTCTGCAGGAAACAGAACA	0.517000													45	119					0	0	1	0	0
PI3	5266	broad.mit.edu	37	20	43803611	43803611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43803611G>A	ENST00000243924.3	+	1	95	c.48G>A	c.(46-48)ggG>ggA	p.G16G		NM_002638.3	NP_002629.1	P19957	ELAF_HUMAN	peptidase inhibitor 3, skin-derived	16					copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity			large_intestine(1)|lung(5)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				TCATCGCTGGGACGCTGGTTC	0.577000													20	57					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214889	140214889	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140214889T>C	ENST00000525929.1	+	1	921	c.921T>C	c.(919-921)caT>caC	p.H307H	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.H307H|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATAGGACATATGGATTTTG	0.448000													16	27					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7152762	7152762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7152762G>A	ENST00000341500.5	-	10	2245	c.2206C>T	c.(2206-2208)Ctg>Ttg	p.L736L	INSR_ENST00000302850.5_Silent_p.L736L	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	736					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACGTTGTGCAGGTAATCCTCA	0.542000													62	156					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155287561	155287561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155287561C>T	ENST00000357232.3	-	5	494	c.495G>A	c.(493-495)gtG>gtA	p.V165V	DCHS2_ENST00000339452.1_Silent_p.V759V	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	165	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCTCCAGGTCCACACGAACAA	0.468000													10	17					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142574200	142574200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142574200G>A	ENST00000359396.3	-	6	968	c.723C>T	c.(721-723)ctC>ctT	p.L241L	RP11-114L10.2_ENST00000438839.1_RNA	NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	241					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					TGAAAGGGGTGAGACCCTGGT	0.572000													25	32					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1513857	1513857	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1513857G>A	ENST00000421627.2	+	3	1133	c.999G>A	c.(997-999)caG>caA	p.Q333Q	RP11-666I19.2_ENST00000518063.1_RNA	NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	412					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AGGTACCTCAGGATGAGTGGG	0.507000													7	22					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861992	52861992	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52861992G>A	ENST00000343457.3	-	4	1202	c.1196C>T	c.(1195-1197)cCt>cTt	p.P399L		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	399						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GTCAACATAAGGCCTTGTGAA	0.547000													25	68					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24473886	24473886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24473886G>A	ENST00000230036.1	-	6	561	c.451C>T	c.(451-453)Cac>Tac	p.H151Y	GPLD1_ENST00000474784.1_5'UTR	NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	151						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TAGGAGCCGTGAAAATCAATC	0.398000													7	24					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36859727	36859727	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36859727C>T	ENST00000279024.4	-	5	2019	c.1747_splice	c.e5-1	p.G583_splice		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	583										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GTCCCGGCCACCTGGAGGACA	0.632000													3	4					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115143510	115143510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115143510C>T	ENST00000393274.1	-	14	2512	c.1887G>A	c.(1885-1887)atG>atA	p.M629I	DENND2C_ENST00000393277.1_Missense_Mutation_p.M629I|DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Missense_Mutation_p.M572I	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	629	DENN.									NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGGAGCTTCCATGACACTTC	0.423000													38	84					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48614394	48614394	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:48614394C>T	ENST00000297423.4	+	13	2269	c.1885C>T	c.(1885-1887)Cca>Tca	p.P629S	SPIDR_ENST00000541342.1_Missense_Mutation_p.P559S|SPIDR_ENST00000517693.1_Missense_Mutation_p.P104S|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000518074.1_Missense_Mutation_p.P569S	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		TTACCAGCCTCCAGTTACCCG	0.448000													95	248					0	0	1	0	0
TMEM50A	23585	broad.mit.edu	37	1	25666982	25666982	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:25666982C>T	ENST00000374358.4	+	2	558	c.5C>T	c.(4-6)tCt>tTt	p.S2F	TMEM50A_ENST00000480937.1_3'UTR	NM_014313.3	NP_055128.1	O95807	TM50A_HUMAN	transmembrane protein 50A	2						endoplasmic reticulum|integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;3.47e-27)|Colorectal(126;1.1e-08)|COAD - Colon adenocarcinoma(152;7.48e-07)|STAD - Stomach adenocarcinoma(196;0.00035)|BRCA - Breast invasive adenocarcinoma(304;0.00047)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|GBM - Glioblastoma multiforme(114;0.00106)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.204)		AAAAAAATGTCTGGATTTCTA	0.368000													7	73					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197208454	197208454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197208454C>T	ENST00000260983.2	-	3	509	c.327G>A	c.(325-327)aaG>aaA	p.K109K	HECW2_ENST00000409111.1_5'UTR	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	109					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CACCCCTGTTCTTAGAATCCC	0.383000													70	191					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84075595	84075595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84075595G>A	ENST00000299709.3	-	1	167	c.168C>T	c.(166-168)gtC>gtT	p.V56V		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	56					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						GGAAGGCAGGGACCACTCCGC	0.622000													52	111					0	0	1	0	0
RRP8	23378	broad.mit.edu	37	11	6624662	6624662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6624662G>A	ENST00000254605.6	-	1	188	c.71C>T	c.(70-72)cCt>cTt	p.P24L	RRP8_ENST00000534343.1_Missense_Mutation_p.P24L	NM_015324.3	NP_056139.1	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase, homolog (yeast)	24					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)	13						CGCAGGCGGAGGTCGTGAGAT	0.667000													4	11					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168265363	168265363	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:168265363C>T	ENST00000366806.2	+	2	380	c.238C>T	c.(238-240)Cga>Tga	p.R80*	MLLT4_ENST00000351017.4_Nonsense_Mutation_p.R80*|MLLT4_ENST00000392108.3_Nonsense_Mutation_p.R80*|MLLT4_ENST00000392112.1_Nonsense_Mutation_p.R80*|MLLT4_ENST00000344191.4_Nonsense_Mutation_p.R80*|MLLT4_ENST00000400822.3_Nonsense_Mutation_p.R80*|MLLT4_ENST00000447894.2_Nonsense_Mutation_p.R80*			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	80	Ras-associating 1.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GGAGAAATTTCGACCTGATAT	0.453000			T	MLL	AL								100	114					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63487353	63487353	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63487353C>T	ENST00000377819.5	+	3	1533	c.1379C>T	c.(1378-1380)tCt>tTt	p.S460F	RTN3_ENST00000540798.1_Missense_Mutation_p.S348F|RTN3_ENST00000339997.4_Missense_Mutation_p.S441F|RTN3_ENST00000341307.2_Intron|RTN3_ENST00000356000.3_Intron|RTN3_ENST00000354497.4_Intron|RTN3_ENST00000537981.1_Intron	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	460					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						AAATGTGACTCTTTGGGTTCT	0.448000													37	89					0	0	1	0	0
ADPRH	141	broad.mit.edu	37	3	119305142	119305142	+	Silent	SNP	G	G	A	rs142760415	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119305142G>A	ENST00000478399.1	+	3	1714	c.309G>A	c.(307-309)tcG>tcA	p.S103S	ADPRH_ENST00000465513.1_Silent_p.S103S|ADPRH_ENST00000478927.1_Silent_p.S103S|ADPRH_ENST00000357003.3_Silent_p.S103S|ADPRH_ENST00000471850.1_3'UTR			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	103					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		GTGGTGCCTCGGTGCACAACG	0.567000													21	249					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28121693	28121693	+	Silent	SNP	C	C	T	rs62638669	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28121693C>T	ENST00000330236.6	+	6	1819	c.1635C>T	c.(1633-1635)ccC>ccT	p.P545P	ZKSCAN8_ENST00000457389.2_Silent_p.P545P	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		GGGAGAAGCCCTACCAATGTA	0.423000													17	103					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73681055	73681055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73681055G>A	ENST00000339764.1	+	8	1598	c.847G>A	c.(847-849)Gac>Aac	p.D283N	RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000543947.1_Missense_Mutation_p.D108N|DNAJB13_ENST00000537753.1_Missense_Mutation_p.D108N	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	283					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					ATTGCCGGAGGACCCCACTAA	0.552000													67	144					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6174883	6174883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6174883G>A	ENST00000264870.3	-	12	1942	c.1677C>T	c.(1675-1677)acC>acT	p.T559T		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	559					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CGGTGTAGAAGGTGATGTTGG	0.502000													20	151					0	0	1	0	0
KRT36	8689	broad.mit.edu	37	17	39642774	39642774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39642774G>A	ENST00000393986.2	-	8	1320	c.1108C>T	c.(1108-1110)Cct>Tct	p.P370S	KRT36_ENST00000328119.6_Missense_Mutation_p.P420S			O76013	KRT36_HUMAN	keratin 36	420	Coil 2.|Rod.					intermediate filament	protein binding|structural constituent of epidermis			breast(2)|cervix(1)|kidney(2)|large_intestine(3)|lung(8)|skin(1)	17		Breast(137;0.000286)				GGGACAGAAGGAACTCTAATA	0.597000													8	9					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313535	54313535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54313535C>T	ENST00000324134.6	-	3	1546	c.1378G>A	c.(1378-1380)Ggg>Agg	p.G460R	NLRP12_ENST00000354278.3_Missense_Mutation_p.G460R|NLRP12_ENST00000391772.1_Missense_Mutation_p.G460R|NLRP12_ENST00000351894.4_Missense_Mutation_p.G460R|NLRP12_ENST00000391775.3_Missense_Mutation_p.G460R|NLRP12_ENST00000535162.1_Missense_Mutation_p.G460R|NLRP12_ENST00000345770.5_Missense_Mutation_p.G460R|NLRP12_ENST00000391773.1_Missense_Mutation_p.G460R	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	460	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GAGCACAACCCTCTCTGGTTG	0.617000													38	79					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25150165	25150165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25150165G>A	ENST00000332271.5	-	8	1209	c.793C>T	c.(793-795)Ctt>Ttt	p.L265F	PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.L156F|PIWIL3_ENST00000533313.1_Missense_Mutation_p.L156F	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	265					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						ACATAACCAAGCCAGATTTCC	0.403000													15	65					0	0	1	0	0
CPLX3	594855	broad.mit.edu	37	15	75122494	75122494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75122494C>T	ENST00000395018.4	+	3	433	c.276C>T	c.(274-276)atC>atT	p.I92I	RP11-414J4.2_ENST00000564823.1_RNA	NM_001030005.2	NP_001025176.1	Q8WVH0	CPLX3_HUMAN	complexin 3	92						cell junction|synapse	syntaxin binding			large_intestine(2)|lung(2)	4						AGAGCCAGATCCAGATGGCAG	0.612000													17	66					0	0	1	0	0
IL17REL	400935	broad.mit.edu	37	22	50436142	50436142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50436142C>T	ENST00000389983.2	-	12	1113	c.849G>A	c.(847-849)cgG>cgA	p.R283R	IL17REL_ENST00000341280.5_Silent_p.R283R	NM_001001694.2	NP_001001694.2	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	283										endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CGAAAGGGCACCGCACCCAGG	0.587000													15	58					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398393	89398393	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89398393G>A	ENST00000439576.2	+	12	2951	c.2577G>A	c.(2575-2577)gaG>gaA	p.E859E	ACAN_ENST00000352105.7_Silent_p.E859E|ACAN_ENST00000559004.1_Silent_p.E859E|ACAN_ENST00000561243.1_Silent_p.E859E	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	859					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCTCTGGGGAGGAATCTGGGG	0.607000													10	47					0	0	1	0	0
XPO6	23214	broad.mit.edu	37	16	28118871	28118871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28118871G>A	ENST00000304658.5	-	18	2969	c.2469C>T	c.(2467-2469)gcC>gcT	p.A823A	XPO6_ENST00000565698.1_Silent_p.A809A	NM_015171.2	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	823					protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						CTGGAAAGAGGGCCAGGGAGA	0.532000													26	71					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4730287	4730287	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4730287C>T	ENST00000354582.6	+	31	4161	c.3811C>T	c.(3811-3813)Ctg>Ttg	p.L1271L	ITPR1_ENST00000456211.2_Silent_p.L1247L|ITPR1_ENST00000443694.2_Silent_p.L1256L|ITPR1_ENST00000423119.2_Silent_p.L1262L|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Silent_p.L1262L|ITPR1_ENST00000302640.8_Silent_p.L1256L			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1271					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ACACATAAACCTGTTTCTCAA	0.458000													5	59					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307510	140307510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140307510C>T	ENST00000253807.2	+	1	1033	c.1033C>T	c.(1033-1035)Ctt>Ttt	p.L345F	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.L345F|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCCTGACTCTTTCGAACCC	0.527000													48	115					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971770	96971770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96971770C>T	ENST00000341686.3	+	6	1016	c.891C>T	c.(889-891)ttC>ttT	p.F297F	C10orf129_ENST00000394005.3_Silent_p.F297F|C10orf129_ENST00000430183.1_Silent_p.F142F	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	297					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		TGCCAACCTTCTGCCCTGAGA	0.502000													19	51					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136661588	136661588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136661588G>A	ENST00000371851.1	-	10	1305	c.980C>T	c.(979-981)cCc>cTc	p.P327L	VAV2_ENST00000406606.3_Missense_Mutation_p.P327L|VAV2_ENST00000371850.3_Missense_Mutation_p.P332L			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	332	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CCTCTGCATGGGGACCACCAG	0.612000													7	27					0	0	1	0	0
OR5K3	403277	broad.mit.edu	37	3	98109721	98109721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98109721C>T	ENST00000383695.1	+	1	212	c.212C>T	c.(211-213)tCc>tTc	p.S71F	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005516.1	NP_001005516.1	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K, member 3	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|prostate(1)|skin(1)|urinary_tract(1)	27						CTGATGGATTCCTGCTGTTCC	0.393000													106	289					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44815231	44815231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44815231G>A	ENST00000372262.3	-	9	2059	c.1659C>T	c.(1657-1659)atC>atT	p.I553I	CDH22_ENST00000537909.1_Silent_p.I553I	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	553	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GCTCACCTTGGATGTCAAGCA	0.597000													21	63					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967584	41967584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41967584G>A	ENST00000298919.7	+	10	2611	c.2223G>A	c.(2221-2223)aaG>aaA	p.K741K	PDZRN4_ENST00000539469.2_Silent_p.K743K|PDZRN4_ENST00000402685.2_Silent_p.K1001K			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	1001							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AGAGAAACAAGAAAATTTTGG	0.458000													10	36					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54530490	54530490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:54530490G>A	ENST00000373968.3	-	2	308	c.244C>T	c.(244-246)Cca>Tca	p.P82S	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	82	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						GAAGGCCCTGGATTTCCTGGA	0.547000													28	132					0	0	1	0	0
CLEC6A	93978	broad.mit.edu	37	12	8612237	8612237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8612237G>A	ENST00000382073.3	+	3	352	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K		NM_001007033.1	NP_001007034.1	Q6EIG7	CLC6A_HUMAN	C-type lectin domain family 6, member A	56					defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)|large_intestine(2)|lung(7)	10	Lung SC(5;0.184)					AAGGCTGTCTGAACTACACTC	0.363000													20	148					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131519878	131519878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131519878C>T	ENST00000423981.1	+	2	343	c.233C>T	c.(232-234)cCc>cTc	p.P78L	AMER3_ENST00000321420.4_Missense_Mutation_p.P78L	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		AAAGGGGGACCCGCAGCCCTC	0.652000													7	10					0	0	1	0	0
MTL5	9633	broad.mit.edu	37	11	68478463	68478463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68478463C>T	ENST00000255087.5	-	9	1396	c.1213G>A	c.(1213-1215)Gaa>Aaa	p.E405K		NM_004923.3	NP_004914.2	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific (tesmin)	405	CXC 2.				cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	15	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TCTGGGCTTTCTTCATAATTT	0.393000													20	51					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96731038	96731038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96731038C>T	ENST00000216629.6	+	3	1625	c.1019C>T	c.(1018-1020)tCa>tTa	p.S340L	BDKRB1_ENST00000553356.1_Intron|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	340					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		CCAATATCTTCATCCCATAGG	0.388000													65	162					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149521605	149521605	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149521605C>T	ENST00000378016.2	+	0	13684							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCAACTGGCCTCTCCCCCAC	0.711000													16	40					0	0	1	0	0
HMG20B	10362	broad.mit.edu	37	19	3578095	3578095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3578095C>T	ENST00000333651.6	+	9	1000	c.925C>T	c.(925-927)Ctg>Ttg	p.L309L		NM_006339.2	NP_006330.2	Q9P0W2	HM20B_HUMAN	high mobility group 20B	309					blood coagulation|cell cycle|chromatin modification	chromosome|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGGAAATCCTGGCCCAGGT	0.706000													6	23					0	0	1	0	0
ADCY3	109	broad.mit.edu	37	2	25141452	25141452	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:25141452G>A	ENST00000260600.5	-	1	1256	c.405C>T	c.(403-405)acC>acT	p.T135T		NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	135					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GCACTCTGCGGGTGACCCGGT	0.627000													7	92					0	0	1	0	0
OR8K5	219453	broad.mit.edu	37	11	55927463	55927463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55927463C>T	ENST00000313447.1	-	1	330	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATGAAAAATTCACTGATAATG	0.418000													12	117					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25593852	25593852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:25593852C>T	ENST00000269141.3	-	3	617	c.194G>A	c.(193-195)gGa>gAa	p.G65E	CDH2_ENST00000399380.3_Missense_Mutation_p.G34E	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	65					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TTTTCTTTTTCCATTGCAGTT	0.358000													15	53					0	0	1	0	0
IGFL1	374918	broad.mit.edu	37	19	46733686	46733686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46733686G>A	ENST00000437936.1	+	3	258	c.235G>A	c.(235-237)Gag>Aag	p.E79K		NM_198541.1	NP_940943.1	Q6UW32	IGFL1_HUMAN	IGF-like family member 1	79						extracellular space	protein binding			lung(5)	5		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.00242)|all cancers(93;0.0132)|GBM - Glioblastoma multiforme(486;0.0294)|Epithelial(262;0.201)		AGTCTGCTTTGAGCAGTGCTG	0.572000													32	125					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307697	46307697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46307697G>A	ENST00000221538.3	-	3	1608	c.1466C>T	c.(1465-1467)tCg>tTg	p.S489L	RSPH6A_ENST00000597055.1_Missense_Mutation_p.S489L|RSPH6A_ENST00000600188.1_Missense_Mutation_p.S225L	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	489						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						CGTGGCGGCCGAGATGCGGGC	0.642000													23	52					0	0	1	0	0
MRPL21	219927	broad.mit.edu	37	11	68664142	68664142	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68664142G>A	ENST00000362034.2	-	4	246	c.237C>T	c.(235-237)gtC>gtT	p.V79V	MRPL21_ENST00000450904.2_5'UTR|MRPL21_ENST00000567045.1_5'UTR	NM_181514.1|NM_181515.1	NP_852615.1|NP_852616.1	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21	79					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome			large_intestine(1)|lung(6)|prostate(1)	8			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCTTCTTCACGACCTCTGCAG	0.632000													27	100					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154876048	154876048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:154876048C>T	ENST00000287907.2	+	2	1501	c.925C>T	c.(925-927)Ccc>Tcc	p.P309S	HTR5A_ENST00000486819.1_3'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	309						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GCTCATCAGTCCCCTCTGCTC	0.572000													46	143					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274047	10274047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10274047C>T	ENST00000396573.2	-	3	531	c.222G>A	c.(220-222)atG>atA	p.M74I	GRIN2A_ENST00000404927.2_Missense_Mutation_p.M74I|GRIN2A_ENST00000562109.1_Missense_Mutation_p.M74I|GRIN2A_ENST00000330684.3_Missense_Mutation_p.M74I|GRIN2A_ENST00000396575.2_Missense_Mutation_p.M74I	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	74					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGGTGCGGTTCATCAGCAGAG	0.662000													45	91					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46328540	46328540	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46328540G>A	ENST00000245934.7	-	18	2623	c.2379C>T	c.(2377-2379)ctC>ctT	p.L793L		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	793					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GGGCCAGGTAGAGGTACAGAC	0.612000													12	44					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999572	46999572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46999572C>T	ENST00000374314.4	+	1	1647	c.692C>T	c.(691-693)cCa>cTa	p.P231L	GPRIN2_ENST00000374317.1_Missense_Mutation_p.P231L			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	231										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GCTCTGCCCCCAGCTGCTCTA	0.627000													15	38					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107773266	107773266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:107773266C>T	ENST00000311955.3	-	2	1199	c.1145G>A	c.(1144-1146)tGa>tAa	p.*382*		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	0					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			TTTGAAGGTTCACTTGAGTAG	0.413000													74	161					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20848472	20848472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20848472G>A	ENST00000262715.5	-	34	4965	c.4925C>T	c.(4924-4926)tCg>tTg	p.S1642L	TEP1_ENST00000556935.1_Missense_Mutation_p.S1534L|TEP1_ENST00000545983.1_5'UTR	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1642					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGAGAGCAGCGAGGCTTGGTG	0.587000													68	154					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81592522	81592522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81592522C>T	ENST00000394660.2	+	14	3215	c.2855C>T	c.(2854-2856)tCt>tTt	p.S952F	IL16_ENST00000302987.4_Missense_Mutation_p.S952F|IL16_ENST00000394652.2_Missense_Mutation_p.S251F	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	952					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GCTGAGGAATCTCAAGGCCCA	0.617000													50	46					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409275	105409275	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105409275G>A	ENST00000333244.5	-	7	12632	c.12513C>T	c.(12511-12513)tcC>tcT	p.S4171S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4171						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCCTGCATGGAGGGGAGGC	0.632000													106	251					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7287995	7287995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7287995G>A	ENST00000537408.1	+	3	1030	c.492G>A	c.(490-492)gcG>gcA	p.A164A	CLSTN3_ENST00000266546.6_Silent_p.A152A			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	152	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						TGTATCGTGCGGCTGTGACAG	0.567000													25	56					0	0	1	0	0
OBP2B	29989	broad.mit.edu	37	9	136083927	136083927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136083927C>T	ENST00000372034.3	-	2	176	c.135G>A	c.(133-135)agG>agA	p.R45R	OBP2B_ENST00000372032.2_Intron|OBP2B_ENST00000461961.1_Intron	NM_014581.2	NP_055396.1	Q9NPH6	OBP2B_HUMAN	odorant binding protein 2B	45					chemosensory behavior|sensory perception of smell	extracellular region	odorant binding|transporter activity			central_nervous_system(2)|large_intestine(1)|lung(3)|skin(1)	7				OV - Ovarian serous cystadenocarcinoma(145;3.41e-06)|Epithelial(140;1.88e-05)		CCTTCCTGGGCCTCCTGTCCT	0.622000													11	11					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639996	7639996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7639996G>A	ENST00000359156.4	-	8	2211	c.2009C>T	c.(2008-2010)tCa>tTa	p.S670L	CD163_ENST00000541972.1_Missense_Mutation_p.S658L|CD163_ENST00000396620.3_Missense_Mutation_p.S703L|CD163_ENST00000432237.2_Missense_Mutation_p.S670L	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	670	SRCR 6.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AGGACATAATGAAGCACCTAG	0.483000													25	45					0	0	1	0	0
CDC34	997	broad.mit.edu	37	19	532077	532077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:532077C>T	ENST00000215574.4	+	1	364	c.146C>T	c.(145-147)cCc>cTc	p.P49L		NM_004359.1	NP_004350.1	P49427	UB2R1_HUMAN	cell division cycle 34	49					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(1)	2		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCGGGCCCCCCAACACCTAC	0.687000													3	12					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122833219	122833219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122833219C>T	ENST00000264811.5	-	4	1570	c.1152G>A	c.(1150-1152)atG>atA	p.M384I	TRPC3_ENST00000379645.3_Missense_Mutation_p.M457I|TRPC3_ENST00000513531.1_Missense_Mutation_p.M329I	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	372					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CTACAAACTTCATAAAAGGGC	0.443000													21	43					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6309836	6309836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6309836G>A	ENST00000301452.4	-	4	437	c.360C>T	c.(358-360)ttC>ttT	p.F120F		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	120						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						CCAGGCGGATGAACTGGGACC	0.617000													15	38					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142572322	142572322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142572322G>A	ENST00000359396.3	-	11	1619	c.1374C>T	c.(1372-1374)ctC>ctT	p.L458L		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	458					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					AGCCCAGCACGAGTGCAAAGG	0.592000													22	44					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35824855	35824855	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35824855C>T	ENST00000314607.6	+	3	495	c.415C>T	c.(415-417)Cct>Tct	p.P139S	ZMYM4_ENST00000373297.2_Missense_Mutation_p.P139S|ZMYM4-AS1_ENST00000432683.1_RNA	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	139					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAAGACTTTCCTAAACAATT	0.308000													11	40					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154412272	154412272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:154412272C>T	ENST00000414028.2	+	3	879	c.829C>T	c.(829-831)Ctt>Ttt	p.L277F	OPRM1_ENST00000428397.2_Missense_Mutation_p.L277F|OPRM1_ENST00000229768.5_Missense_Mutation_p.L277F|OPRM1_ENST00000435918.2_Missense_Mutation_p.L277F|OPRM1_ENST00000522236.1_Missense_Mutation_p.L177F|OPRM1_ENST00000524163.1_Missense_Mutation_p.L277F|OPRM1_ENST00000452687.2_Missense_Mutation_p.L277F|OPRM1_ENST00000330432.7_Missense_Mutation_p.L277F|OPRM1_ENST00000360422.4_Missense_Mutation_p.L277F|OPRM1_ENST00000434900.2_Missense_Mutation_p.L370F|OPRM1_ENST00000520708.1_Missense_Mutation_p.L177F|OPRM1_ENST00000337049.4_Missense_Mutation_p.L277F|OPRM1_ENST00000518759.1_Missense_Mutation_p.L196F|OPRM1_ENST00000419506.2_Missense_Mutation_p.L277F|OPRM1_ENST00000522555.1_Missense_Mutation_p.L177F	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	277					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	GGACAGGAATCTTCGAAGGAT	0.488000													36	45					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48389216	48389216	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48389216G>A	ENST00000224600.4	-	1	1775	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	554	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	ACTGCATAAGGAAGGCGAACT	0.672000													27	49					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26228908	26228908	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26228908C>T	ENST00000335473.7	+	16	3254	c.3004C>T	c.(3004-3006)Ctc>Ttc	p.L1002F	MYO18B_ENST00000536101.1_Missense_Mutation_p.L1002F|MYO18B_ENST00000407587.2_Missense_Mutation_p.L1002F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1002	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCAGTTTGACCTCCCGGACCC	0.507000													11	88					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27220706	27220706	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:27220706G>A	ENST00000230582.3	+	9	1143	c.1128G>A	c.(1126-1128)caG>caA	p.Q376Q	PRSS16_ENST00000421826.2_Silent_p.Q119Q|PRSS16_ENST00000377456.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	376					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GGTTGTATCAGACATGTACCG	0.502000													58	125					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43226909	43226909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43226909C>T	ENST00000259750.4	+	11	1233	c.1150C>T	c.(1150-1152)Ccc>Tcc	p.P384S	TTBK1_ENST00000304139.5_Missense_Mutation_p.P333S	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	384						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGGGCTGGGCCCCAGTCCCCA	0.627000													20	75					0	0	1	0	0
WWC1	23286	broad.mit.edu	37	5	167882460	167882460	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167882460C>T	ENST00000265293.4	+	19	3260	c.2758C>T	c.(2758-2760)Cga>Tga	p.R920*	WWC1_ENST00000521089.1_Nonsense_Mutation_p.R920*|WWC1_ENST00000522140.1_3'UTR	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	920	Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GCCATTTCTTCGAGGGAGCAC	0.642000													31	151					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61463546	61463546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61463546G>A	ENST00000398019.2	+	5	708	c.383G>A	c.(382-384)cGa>cAa	p.R128Q	SERPINB7_ENST00000336429.2_Missense_Mutation_p.R128Q|SERPINB7_ENST00000546027.1_Missense_Mutation_p.R128Q|SERPINB7_ENST00000540675.1_Missense_Mutation_p.R111Q	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	128					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				AAAGTGGAGCGAGTTGACTTT	0.328000													11	62					0	0	1	0	0
CDKL4	344387	broad.mit.edu	37	2	39406354	39406354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:39406354C>T	ENST00000378803.1	-	8	900	c.901G>A	c.(901-903)Gaa>Aaa	p.E301K	CDKL4_ENST00000395035.3_Missense_Mutation_p.E301K	NM_001009565.1	NP_001009565.1	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	301						cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)|large_intestine(2)|liver(1)|lung(7)|ovary(1)	12		all_hematologic(82;0.248)				TTTCTTCCTTCATTACGTGCT	0.378000													36	141					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6749668	6749668	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6749668C>T	ENST00000229243.2	-	7	1191	c.1098G>A	c.(1096-1098)cgG>cgA	p.R366R	ACRBP_ENST00000542357.1_5'UTR|ACRBP_ENST00000414226.2_Silent_p.R333R	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	366						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						ACATGTGTCGCCGCCCAAGGC	0.637000													4	17					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139155304	139155304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139155304C>T	ENST00000395297.1	-	16	3759	c.3589G>A	c.(3589-3591)Gaa>Aaa	p.E1197K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1197										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGAATGATTTCATCCAATAAC	0.458000										HNSCC(54;0.14)			6	60					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83764144	83764144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83764144G>A	ENST00000265362.3	-	2	550	c.236C>T	c.(235-237)tCa>tTa	p.S79L	SEMA3A_ENST00000436949.1_Missense_Mutation_p.S79L	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	79	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CAGGTCGAATGAAAATATGTG	0.358000													22	63					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170327882	170327882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:170327882G>A	ENST00000439128.2	-	30	3795	c.3155C>T	c.(3154-3156)tCa>tTa	p.S1052L	NEK1_ENST00000510533.1_Missense_Mutation_p.S1008L|NEK1_ENST00000512193.1_Missense_Mutation_p.S983L|NEK1_ENST00000511633.1_Missense_Mutation_p.S1036L|NEK1_ENST00000507142.1_Missense_Mutation_p.S1080L	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1052					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		ATCTGGAAGTGAACATGTCCT	0.313000													23	41					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160789114	160789114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160789114C>T	ENST00000263285.5	+	7	1478	c.1448C>T	c.(1447-1449)tCa>tTa	p.S483L	LY9_ENST00000368035.1_Missense_Mutation_p.S135L|LY9_ENST00000368041.2_Missense_Mutation_p.S353L|LY9_ENST00000341032.4_Missense_Mutation_p.S393L|LY9_ENST00000368040.1_Missense_Mutation_p.S135L	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	483					cell adhesion|immunoglobulin mediated immune response	integral to membrane		p.S483*(1)		autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTCTCAGGTTCAGTCCCAGCC	0.493000													41	89					0	0	1	0	0
AKR1C1	1645	broad.mit.edu	37	10	5011070	5011070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5011070C>T	ENST00000380872.4	+	5	696	c.504C>T	c.(502-504)ttC>ttT	p.F168F	AKR1C1_ENST00000434459.2_Silent_p.F168F|AKR1C1_ENST00000380859.1_Silent_p.F170F|AKR1C1_ENST00000477661.1_3'UTR	NM_001353.5	NP_001344.2			aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						TGTCCAACTTCAACCGCAGGC	0.517000													42	80					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51759245	51759245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51759245C>T	ENST00000543196.2	-	4	988	c.783G>A	c.(781-783)caG>caA	p.Q261Q	GALNT6_ENST00000356317.3_Silent_p.Q261Q			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	261	Catalytic subdomain A.				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						GCACCTCCGCCTGTGCCACGC	0.672000													22	52					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364297	5364297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5364297G>A	ENST00000300773.2	-	1	512	c.458C>T	c.(457-459)tCc>tTc	p.S153F	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGAACAACGGATACAAATCC	0.443000													24	77					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79375891	79375891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79375891G>A	ENST00000350881.2	+	20	2865	c.2675G>A	c.(2674-2676)gGc>gAc	p.G892D	THBS4_ENST00000511733.1_Missense_Mutation_p.G801D|CTD-2201I18.1_ENST00000514042.1_RNA|CTD-2201I18.1_ENST00000503007.1_RNA|THBS4_ENST00000504720.1_3'UTR	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	892	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CCCCAGGTGGGCTACATCAGG	0.557000													3	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179599464	179599464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179599464C>T	ENST00000589042.1	-	51	15411	c.15187G>A	c.(15187-15189)Gat>Aat	p.D5063N	TTN_ENST00000342992.6_Missense_Mutation_p.D3819N|TTN_ENST00000591111.1_Missense_Mutation_p.D4746N|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4746	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCAGCTATCACTGCCGACG	0.353000													40	146					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566641	5566641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5566641G>A	ENST00000322653.4	-	1	138	c.113C>T	c.(112-114)cCc>cTc	p.P38L	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATACAGAAGGGAATTCCAAT	0.458000													29	58					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21425035	21425035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21425035G>A	ENST00000313654.9	+	30	3907	c.3666G>A	c.(3664-3666)atG>atA	p.M1222I	LAMA3_ENST00000399516.3_Missense_Mutation_p.M1222I	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1222	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAAATCCATGGACAAGTCAC	0.423000													15	38					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101739389	101739389	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101739389C>T	ENST00000261637.4	+	37	4837	c.4663C>T	c.(4663-4665)Caa>Taa	p.Q1555*		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1555					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						CTTTCCAAACCAACTGGAATT	0.338000													22	64					0	0	1	0	0
MMP19	4327	broad.mit.edu	37	12	56236591	56236591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56236591C>T	ENST00000322569.4	-	1	115	c.24G>A	c.(22-24)ctG>ctA	p.L8L	MMP19_ENST00000409200.3_Silent_p.L8L|MMP19_ENST00000547487.1_5'UTR|MMP19_ENST00000548629.1_Silent_p.L8L	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	8					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						GTAGGAAGCCCAGCCACAGCT	0.637000													3	10					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21255406	21255406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21255406G>A	ENST00000233242.1	-	10	1299	c.1172C>T	c.(1171-1173)tCc>tTc	p.S391F	APOB_ENST00000399256.4_Missense_Mutation_p.S391F	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	391	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATGTGAGTGGAGCACTGAGG	0.527000													18	48					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178802677	178802677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:178802677C>T	ENST00000367635.3	+	8	937	c.599C>T	c.(598-600)cCc>cTc	p.P200L	RALGPS2_ENST00000367634.2_Missense_Mutation_p.P200L|RALGPS2_ENST00000324778.4_Missense_Mutation_p.P165L	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	200	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						CCTTGCATTCCCTATTTAGGT	0.289000													27	78					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17698394	17698394	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:17698394C>T	ENST00000399080.2	-	1	1312	c.1289G>A	c.(1288-1290)tGg>tAg	p.W430*		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	430										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TAGCCAATTCCATTTTTCTTC	0.289000													10	21					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102051118	102051118	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102051118C>T	ENST00000318222.3	-	12	2329	c.1947G>A	c.(1945-1947)ggG>ggA	p.G649G	PKD2L1_ENST00000353274.3_Silent_p.G649G|PKD2L1_ENST00000338519.3_Silent_p.G574G	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	649					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		GAATACGATTCCCATCTCTGT	0.502000													48	67					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18170872	18170872	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18170872C>T	ENST00000600835.1	-	17	2118	c.1815G>A	c.(1813-1815)gtG>gtA	p.V605V	IL12RB1_ENST00000593993.1_Silent_p.V605V|IL12RB1_ENST00000430026.2_Silent_p.V605V			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	605					cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCTGGAAGTCCACTGGGTTGA	0.592000													3	18					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51217155	51217155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51217155C>T	ENST00000293441.1	-	5	710	c.692G>A	c.(691-693)cGa>cAa	p.R231Q	SHANK1_ENST00000359082.3_Missense_Mutation_p.R231Q|SHANK1_ENST00000391814.1_Missense_Mutation_p.R231Q	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	231					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCACAGGGTTCGAATCACCTC	0.647000													17	39					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46243472	46243472	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:46243472C>T	ENST00000334344.6	+	14	1997	c.1825C>T	c.(1825-1827)Cag>Tag	p.Q609*	ARID2_ENST00000422737.1_Nonsense_Mutation_p.Q460*|ARID2_ENST00000444670.1_Nonsense_Mutation_p.Q219*|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	609					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACTTCCCATTCAGATGTACTA	0.438000			"""N, S, F"""		hepatocellular carcinoma								73	190					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108382640	108382640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108382640G>A	ENST00000265843.4	-	6	3704	c.3594C>T	c.(3592-3594)tcC>tcT	p.S1198S	EXPH5_ENST00000428840.1_Silent_p.S1122S|EXPH5_ENST00000443411.1_Silent_p.S1010S|EXPH5_ENST00000525344.1_Silent_p.S1191S	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1198					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CACTTCTCCTGGAGGCAGCCA	0.378000													59	139					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151093031	151093031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151093031C>T	ENST00000370340.3	+	3	1162	c.895C>T	c.(895-897)Cgc>Tgc	p.R299C	MAGEA4_ENST00000393920.1_Missense_Mutation_p.R299C|MAGEA4_ENST00000393921.1_Missense_Mutation_p.R299C|MAGEA4_ENST00000370337.4_Missense_Mutation_p.R299C|MAGEA4_ENST00000276344.2_Missense_Mutation_p.R299C|MAGEA4_ENST00000360243.2_Missense_Mutation_p.R299C|MAGEA4_ENST00000370335.1_Missense_Mutation_p.R299C			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	299	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGCAAGAGTTCGCATTGCCTA	0.567000													67	50					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64527218	64527218	+	Missense_Mutation	SNP	C	C	T	rs141560382	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64527218C>T	ENST00000498707.1	-	34	5618	c.5276G>A	c.(5275-5277)aGa>aAa	p.R1759K	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.R1731K	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1759	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		AAGCTTTCCTCTAATCATCAG	0.398000													54	105					0	0	1	0	0
TPTE2P2	644623	broad.mit.edu	37	13	52854008	52854008	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52854008C>T	ENST00000451298.1	-	0	529				RP11-64P12.8_ENST00000606031.1_RNA																							GACTGGCCTCCCGAAGATGGA	0.303000													3	18					0	0	1	0	0
OR51D1	390038	broad.mit.edu	37	11	4661207	4661207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4661207C>T	ENST00000357605.2	+	1	263	c.187C>T	c.(187-189)Cgt>Tgt	p.R63C		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTCATCATTCGTGTGGAGAG	0.542000													12	72					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65262303	65262303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65262303C>T	ENST00000389722.3	-	11	1449	c.1396G>A	c.(1396-1398)Gcc>Acc	p.A466T	SPTB_ENST00000556626.1_Missense_Mutation_p.A466T|SPTB_ENST00000542895.1_Missense_Mutation_p.A466T|SPTB_ENST00000389721.5_Missense_Mutation_p.A466T|SPTB_ENST00000389720.3_Missense_Mutation_p.A466T	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	466					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GTCTCGATGGCCTCATGCTTC	0.597000													10	69					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394039	154394039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154394039C>T	ENST00000435029.4	+	1	780	c.620C>T	c.(619-621)tCc>tTc	p.S207F		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	207	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GCTATGAACTCCCAGTCGTCC	0.468000													17	146					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151672380	151672380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:151672380G>A	ENST00000402676.2	+	4	3094	c.2854G>A	c.(2854-2856)Gaa>Aaa	p.E952K	AKAP12_ENST00000359755.5_Missense_Mutation_p.E847K|AKAP12_ENST00000354675.6_Missense_Mutation_p.E854K|AKAP12_ENST00000253332.1_Missense_Mutation_p.E952K	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	952					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CACGGTTACTGAACCTCTGCC	0.532000													25	72					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098882	11098882	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11098882C>T	ENST00000470054.1	-	0	43									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tctcctggtcctctaagccgg	0.607000													4	27					0	0	1	0	0
WNT6	7475	broad.mit.edu	37	2	219736279	219736279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219736279C>T	ENST00000233948.3	+	3	591	c.374C>T	c.(373-375)tCt>tTt	p.S125F	WNT6_ENST00000486233.1_3'UTR	NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	125					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGGCCTGTTCTATGGGCGAG	0.741000													9	21					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815292	43815292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43815292G>A	ENST00000382031.1	+	5	2366	c.2335G>A	c.(2335-2337)Gag>Aag	p.E779K	MAP1A_ENST00000399453.1_Missense_Mutation_p.E541K|MAP1A_ENST00000300231.5_Missense_Mutation_p.E541K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	541						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GATGAAGCGTGAGGAGAGGGC	0.552000													33	117					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1103314	1103314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1103314C>T	ENST00000441003.2	+	46	8091	c.8064C>T	c.(8062-8064)atC>atT	p.I2688I		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	5050						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GCATTTGCATCCCGGTGAGTT	0.602000													5	56					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18331127	18331127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18331127G>A	ENST00000355502.3	-	11	1582	c.711C>T	c.(709-711)ttC>ttT	p.F237F	PDE4C_ENST00000594465.2_Silent_p.F237F|PDE4C_ENST00000262805.11_Silent_p.F205F|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000539010.1_Silent_p.F6F|PDE4C_ENST00000447275.2_Silent_p.F131F|PDE4C_ENST00000594617.2_Silent_p.F237F			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	237					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GGATCCGCTTGAACTGGGGCG	0.622000													39	101					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46976894	46976894	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46976894G>A	ENST00000371253.2	-	11	2492	c.2277C>T	c.(2275-2277)ttC>ttT	p.F759F	GPR110_ENST00000283297.5_Silent_p.F562F|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	759					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						GCACCACAACGAAGTTCACAG	0.527000													30	55					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77776193	77776193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77776193G>A	ENST00000521891.2	+	11	10691	c.10243G>A	c.(10243-10245)Gaa>Aaa	p.E3415K	ZFHX4_ENST00000455469.2_Missense_Mutation_p.E3370K|ZFHX4_ENST00000050961.6_Missense_Mutation_p.E3366K|ZFHX4_ENST00000518282.1_Missense_Mutation_p.E3389K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3366						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTTTACTGATGAAGACGCCGC	0.418000										HNSCC(33;0.089)			3	20					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370122	240370122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240370122G>A	ENST00000319653.9	+	5	2240	c.2010G>A	c.(2008-2010)gaG>gaA	p.E670E		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	670					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGAAGTCTGAGGGACAGGCCA	0.423000													15	51					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84582010	84582010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84582010G>A	ENST00000286744.5	+	16	2091	c.1867G>A	c.(1867-1869)Gaa>Aaa	p.E623K	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.E623K	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	623	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGCCTCCTGGAAGCATGTGA	0.612000													18	50					0	0	1	0	0
RSPH1	89765	broad.mit.edu	37	21	43913099	43913099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43913099C>T	ENST00000291536.3	-	2	312	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	RSPH1_ENST00000398352.3_Intron	NM_080860.2	NP_543136.1	Q8WYR4	RSPH1_HUMAN	radial spoke head 1 homolog (Chlamydomonas)	49					meiosis	cytosol|nucleus				large_intestine(7)|lung(2)|ovary(1)|prostate(1)|stomach(1)	12						TTACCGAATTCGTAGCTCCCT	0.502000													58	252					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108682435	108682435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108682435G>A	ENST00000232603.5	-	27	2707	c.2625C>T	c.(2623-2625)gtC>gtT	p.V875V	MORC1_ENST00000483760.1_Silent_p.V854V	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	875					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTTCATATTGGACCATGTAAG	0.284000													9	48					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139874654	139874654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139874654G>A	ENST00000224167.2	+	5	645	c.570G>A	c.(568-570)agG>agA	p.R190R	PTGDS_ENST00000371625.3_Silent_p.R156R			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	156					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGACCCCCAGGGCTGAGTTAA	0.632000													13	39					0	0	1	0	0
TSPAN32	10077	broad.mit.edu	37	11	2334931	2334931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2334931G>A	ENST00000182290.4	+	5	539	c.402G>A	c.(400-402)gcG>gcA	p.A134A	TSPAN32_ENST00000381121.3_Silent_p.A134A|TSPAN32_ENST00000451520.2_Silent_p.A123A|TSPAN32_ENST00000483227.1_3'UTR	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	134					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		ATGAGCAGGCGATGAAAGGTA	0.662000													4	7					0	0	1	0	0
BEX5	340542	broad.mit.edu	37	X	101409099	101409099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:101409099C>T	ENST00000543160.1	-	3	440	c.139G>A	c.(139-141)Gga>Aga	p.G47R	BEX5_ENST00000333643.3_Missense_Mutation_p.G47R	NM_001159560.1	NP_001153032.1	Q5H9J7	BEX5_HUMAN	brain expressed, X-linked 5	47						cytoplasm				large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	4						ACATCCTCTCCAAAACCCGGG	0.517000													42	35					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218940349	218940349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:218940349G>A	ENST00000374155.3	+	8	1604	c.1194G>A	c.(1192-1194)caG>caA	p.Q398Q	RUFY4_ENST00000344321.7_Silent_p.Q378Q|RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000463872.1_3'UTR			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	378							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGGTCCTTCAGGGACACGCAA	0.617000													23	38					0	0	1	0	0
EXOC6	54536	broad.mit.edu	37	10	94653169	94653169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:94653169C>T	ENST00000371552.4	+	2	179	c.150C>T	c.(148-150)atC>atT	p.I50I	EXOC6_ENST00000260762.6_Silent_p.I55I|EXOC6_ENST00000443748.2_Silent_p.I55I|EXOC6_ENST00000371543.1_Silent_p.I55I|EXOC6_ENST00000371547.4_Silent_p.I71I	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	55					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				ATGCTTGTATCCGTAATCATG	0.338000													41	92					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167060669	167060669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167060669G>A	ENST00000375387.4	-	26	4913	c.4573C>T	c.(4573-4575)Ctt>Ttt	p.L1525F	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Missense_Mutation_p.L1524F|SCN9A_ENST00000409672.1_Missense_Mutation_p.L1513F|SCN9A_ENST00000303354.6_Missense_Mutation_p.L1525F			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1524						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AGACAGATAAGAACCATGATA	0.328000													24	48					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60643116	60643116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60643116G>A	ENST00000278853.5	+	12	1904	c.1904G>A	c.(1903-1905)aGc>aAc	p.S635N		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	635					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CTCTGGGAAAGCAACAGACAG	0.493000													14	34					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981915	7981915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7981915G>A	ENST00000328600.2	-	2	1405	c.1244C>T	c.(1243-1245)tCc>tTc	p.S415F		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	415	NACHT.						ATP binding	p.S415F(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCTGCTAGGGAGCACAGACT	0.547000													24	64					0	0	1	0	0
LINC00922	283867	broad.mit.edu	37	16	65345360	65345360	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:65345360G>A	ENST00000569736.1	-	0	775				RP11-256I9.3_ENST00000562656.1_lincRNA	NR_027755.1																						ATGCCTTCACGAATGTATGCC	0.468000													39	113					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133051061	133051061	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133051061C>T	ENST00000262283.5	-	11	1291	c.1192G>A	c.(1192-1194)Gac>Aac	p.D398N	OC90_ENST00000443356.2_Missense_Mutation_p.D202N|OC90_ENST00000254627.3_Missense_Mutation_p.D202N|OC90_ENST00000603859.1_Missense_Mutation_p.D202N			Q02509	OC90_HUMAN	otoconin 90	202	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GTTGTCAAGTCTTCCTTGATG	0.517000													8	21					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4702675	4702675	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4702675C>T	ENST00000354582.6	+	14	1505	c.1155C>T	c.(1153-1155)aaC>aaT	p.N385N	ITPR1_ENST00000456211.2_Silent_p.N370N|ITPR1_ENST00000443694.2_Silent_p.N370N|ITPR1_ENST00000423119.2_Silent_p.N385N|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Silent_p.N385N|ITPR1_ENST00000302640.8_Silent_p.N370N			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	385	MIR 5.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTGTTAGGAACTCTTATGTTC	0.368000													10	32					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121485642	121485642	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121485642G>A	ENST00000260197.7	+	41	5611	c.5482G>A	c.(5482-5484)Gat>Aat	p.D1828N	SORL1_ENST00000527934.1_Missense_Mutation_p.D443N|SORL1_ENST00000525532.1_Missense_Mutation_p.D772N|SORL1_ENST00000532694.1_Missense_Mutation_p.D674N|SORL1_ENST00000534286.1_Missense_Mutation_p.D738N	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1828	Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGACTTGGGGGATAGCCCTCT	0.512000													12	141					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121863	38121863	+	Silent	SNP	C	C	T	rs140427804		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38121863C>T	ENST00000406386.3	+	7	3555	c.3300C>T	c.(3298-3300)tcC>tcT	p.S1100S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1100					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.S1100S(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AGTGTCAGTCCCCCCAACACG	0.667000													69	177					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143100923	143100923	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:143100923C>T	ENST00000316549.6	-	13	1711	c.1503G>A	c.(1501-1503)gaG>gaA	p.E501E	SLC9A9-AS2_ENST00000490153.1_RNA	NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	501					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						AGGAGGGGTCCTCCTTCAGAT	0.443000													26	237					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43579608	43579608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43579608C>T	ENST00000452443.2	-	6	739	c.735G>A	c.(733-735)gaG>gaA	p.E245E		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	245					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TGGAGTAGTCCTCGCCCCAGT	0.602000													12	38					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84270630	84270630	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84270630C>T	ENST00000568181.1	-	2	582	c.462G>A	c.(460-462)gaG>gaA	p.E154E	KCNG4_ENST00000308251.4_Silent_p.E154E			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	154						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						CCAGGTGGGCCTCCTCGATGC	0.652000													18	40					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12947771	12947771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:12947771G>A	ENST00000276297.4	-	15	4473	c.4064C>T	c.(4063-4065)tCc>tTc	p.S1355F	DLC1_ENST00000512044.2_Missense_Mutation_p.S952F|DLC1_ENST00000520226.1_Missense_Mutation_p.S844F|DLC1_ENST00000358919.2_Missense_Mutation_p.S918F|DLC1_ENST00000510318.1_5'UTR	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1355	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CTTCTTATAGGACAGCTCAGC	0.493000													18	63					0	0	1	0	0
IGHV4-4	28401	broad.mit.edu	37	14	106478263	106478263	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106478263C>T	ENST00000390596.2	-	0	258																											GCCCAATCCACTCCAGTCCCT	0.577000													13	59					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61962822	61962822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61962822C>T	ENST00000280772.1	-	12	1521	c.1330G>A	c.(1330-1332)Ggg>Agg	p.G444R	ANK3_ENST00000503366.1_Missense_Mutation_p.G427R|ANK3_ENST00000373827.2_Missense_Mutation_p.G438R	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	444					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTACATGCCCCATGAAGGCA	0.433000													16	59					0	0	1	0	0
CEACAM4	1089	broad.mit.edu	37	19	42125730	42125730	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42125730G>A	ENST00000221954.2	-	7	818	c.708C>T	c.(706-708)atC>atT	p.I236I		NM_001817.2	NP_001808.2	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4	236						integral to plasma membrane|membrane fraction				NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						CTTTGTGGTCGATCTGGCAGT	0.527000													48	108					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53671347	53671347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53671347C>T	ENST00000257934.4	+	10	2270	c.2179C>T	c.(2179-2181)Cgt>Tgt	p.R727C	ESPL1_ENST00000552462.1_Missense_Mutation_p.R727C	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	727					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CCAGGAAGATCGTTTCCTATA	0.502000													21	80					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57746631	57746631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57746631C>T	ENST00000302804.7	+	7	962	c.776C>T	c.(775-777)cCa>cTa	p.P259L	AURKC_ENST00000448930.1_Missense_Mutation_p.P225L|AURKC_ENST00000599062.1_Missense_Mutation_p.P256L|AURKC_ENST00000415300.2_Missense_Mutation_p.P240L|AURKC_ENST00000598785.1_Missense_Mutation_p.P225L	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	259	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		GTGAGGTTTCCACTATCAATG	0.517000													17	36					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95057176	95057176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95057176C>T	ENST00000329597.7	+	5	1191	c.981C>T	c.(979-981)ttC>ttT	p.F327F	SERPINA5_ENST00000553780.1_Silent_p.F327F|SERPINA5_ENST00000554866.1_Silent_p.F327F|SERPINA5_ENST00000554276.1_Silent_p.F327F	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	327					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GTAACGTCTTCACCTCCCATG	0.522000													30	78					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167645800	167645800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167645800C>T	ENST00000519204.1	+	22	4659	c.4541C>T	c.(4540-4542)tCc>tTc	p.S1514F	TENM2_ENST00000545108.1_Missense_Mutation_p.S1634F|TENM2_ENST00000518659.1_Missense_Mutation_p.S1635F|TENM2_ENST00000520394.1_Missense_Mutation_p.S1396F|TENM2_ENST00000403607.2_Missense_Mutation_p.S1459F					teneurin transmembrane protein 2																		AATGGGAATTCCCTGAAGATC	0.498000													41	83					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683752	159683752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159683752C>T	ENST00000255030.5	-	2	341	c.238G>A	c.(238-240)Gag>Aag	p.E80K	CRP_ENST00000368110.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000437342.1_5'UTR|CRP_ENST00000368111.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	80	Pentaxin.			Missing (in Ref. 13; AA sequence).|YSIFSYATKRQDNEIL -> TVFSRMPPRDKTMRFF (in Ref. 4; CAA39671).	acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	ATGAGAATCTCATTGTCTTGT	0.453000													7	102					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102713470	102713470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102713470G>A	ENST00000299855.5	-	2	539	c.283C>T	c.(283-285)Cct>Tct	p.P95S		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	95					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CCAACATCAGGAACTCCACAC	0.493000													17	38					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28343065	28343065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28343065C>T	ENST00000337532.5	-	18	1936	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K	MPP7_ENST00000540098.1_Missense_Mutation_p.E554K|MPP7_ENST00000375719.3_Missense_Mutation_p.E554K|MPP7_ENST00000375732.1_Missense_Mutation_p.E554K	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	554	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						GTTTTGAGCTCATTGAATGCC	0.328000													18	38					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	70880876	70880876	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:70880876G>A	ENST00000333538.5	+	4	1225	c.589_splice	c.e4-1	p.E197_splice	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	197	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CATTTGCAGAGGAGCTGAAGG	0.483000													11	34					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113295194	113295194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113295194G>A	ENST00000362072.3	-	2	524	c.180C>T	c.(178-180)tcC>tcT	p.S60S	DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000346454.3_Silent_p.S60S|DRD2_ENST00000542968.1_Silent_p.S60S|DRD2_ENST00000538967.1_Silent_p.S60S|DRD2_ENST00000355319.2_Silent_p.S60S|DRD2_ENST00000544518.1_Silent_p.S60S	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	60					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding	p.S60S(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CCTTCTCGCGGGACACAGCCA	0.612000													22	56					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916519	42916519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42916519C>T	ENST00000316161.4	-	1	1114	c.790G>A	c.(790-792)Gag>Aag	p.E264K	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Missense_Mutation_p.E264K|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	264					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity	p.E264K(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		ACCCCCTGCTCCCTCAGAAAC	0.577000													8	19					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47532724	47532724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47532724G>A	ENST00000300527.4	+	4	825	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	COL6A2_ENST00000310645.5_Missense_Mutation_p.E241K|COL6A2_ENST00000357838.4_Missense_Mutation_p.E241K|COL6A2_ENST00000409416.1_Missense_Mutation_p.E241K|COL6A2_ENST00000460886.1_3'UTR|COL6A2_ENST00000397763.1_Missense_Mutation_p.E241K	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	241	Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GCAGAAACACGAAGCCTACGG	0.642000													13	71					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4924939	4924939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:4924939G>A	ENST00000333703.4	+	4	555	c.42G>A	c.(40-42)cgG>cgA	p.R14R	PCDH11Y_ENST00000362095.5_Silent_p.R25R|PCDH11Y_ENST00000215473.6_Silent_p.R25R	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	25					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GTGTTGTGCGGGTTAATACAA	0.428000													28	35					0	0	1	0	0
LHX1	3975	broad.mit.edu	37	17	35300245	35300245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:35300245C>T	ENST00000254457.5	+	5	2449	c.1038C>T	c.(1036-1038)atC>atT	p.I346I	RP11-445F12.2_ENST00000607336.1_RNA	NM_005568.3	NP_005559.2	P48742	LHX1_HUMAN	LIM homeobox 1	346					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Breast(25;0.00607)				TTACCGACATCCTGGCGCACC	0.741000													6	6					0	0	1	0	0
GALP	85569	broad.mit.edu	37	19	56696615	56696615	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56696615G>A	ENST00000357330.2	+	6	409	c.327G>A	c.(325-327)aaG>aaA	p.K109K	GALP_ENST00000440823.1_3'UTR	NM_033106.3	NP_149097.1	Q9UBC7	GALP_HUMAN	galanin-like peptide	109					neuropeptide signaling pathway	extracellular region	hormone activity			lung(4)	4		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		AAATTCCCAAGGAGGAAGATG	0.448000													15	39					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198721736	198721736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:198721736G>A	ENST00000367376.2	+	31	3509	c.3338G>A	c.(3337-3339)cGa>cAa	p.R1113Q	PTPRC_ENST00000352140.3_Missense_Mutation_p.R1065Q|PTPRC_ENST00000348564.6_Missense_Mutation_p.R954Q|PTPRC_ENST00000442510.2_Missense_Mutation_p.R1115Q|PTPRC_ENST00000594404.1_Missense_Mutation_p.R952Q	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1113	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AAAGACTCTCGAACTGTGTAC	0.368000													6	24					0	0	1	0	0
EPS8L2	64787	broad.mit.edu	37	11	721583	721583	+	Silent	SNP	C	C	T	rs144181589		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:721583C>T	ENST00000533256.1	+	11	1162	c.787C>T	c.(787-789)Ctg>Ttg	p.L263L	EPS8L2_ENST00000526198.1_Silent_p.L279L|EPS8L2_ENST00000318562.8_Silent_p.L263L|EPS8L2_ENST00000530636.1_Silent_p.L263L|AP006621.9_ENST00000527021.2_RNA			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	263						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAACTGCGCCCTGGACGACAT	0.627000													13	20					0	0	1	0	0
PDHA1	5160	broad.mit.edu	37	X	19377730	19377730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:19377730C>T	ENST00000379806.5	+	12	1391	c.1246C>T	c.(1246-1248)Cgt>Tgt	p.R416C	PDHA1_ENST00000379804.1_Missense_Mutation_p.R97C|PDHA1_ENST00000540249.1_Missense_Mutation_p.R347C|PDHA1_ENST00000422285.2_Missense_Mutation_p.R378C|PDHA1_ENST00000478795.1_3'UTR|PDHA1_ENST00000545074.1_Missense_Mutation_p.R385C	NM_001173454.1	NP_001166925.1	P08559	ODPA_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 1	378					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity	p.R378C(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)	18	Hepatocellular(33;0.183)				NADH(DB00157)	TTTTGAAGTTCGTGGTGCCAA	0.527000													32	23					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41430259	41430259	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41430259G>A	ENST00000599198.1	+	0	136					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TAACTCCCATGGCACCCTCCC	0.587000													27	72					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6422854	6422854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6422854C>T	ENST00000449001.2	+	2	596	c.102C>T	c.(100-102)gcC>gcT	p.A34A	PLEKHG6_ENST00000396988.3_Silent_p.A66A|PLEKHG6_ENST00000011684.7_Silent_p.A66A|PLEKHG6_ENST00000536531.1_Silent_p.A66A	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	66					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						CTGGCCAGGCCCGAGGCCTGT	0.642000													30	66					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130095457	130095457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130095457G>A	ENST00000265379.6	+	3	939	c.445G>A	c.(445-447)Gaa>Aaa	p.E149K	COL6A5_ENST00000432398.2_Missense_Mutation_p.E149K			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	149	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						GTCTGAGGATGAAGTGGAAGA	0.522000													10	17					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21175852	21175852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21175852G>A	ENST00000381541.3	+	5	615	c.550G>A	c.(550-552)Ggg>Agg	p.G184R	SLCO1B7_ENST00000554957.1_Missense_Mutation_p.G184R|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.G137R|SLCO1B3_ENST00000553473.1_Intron																							TCGTGGCATAGGGGAAACCCC	0.368000													15	123					0	0	1	0	0
HRH2	3274	broad.mit.edu	37	5	175110674	175110674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:175110674C>T	ENST00000231683.2	+	1	2211	c.438C>T	c.(436-438)tcC>tcT	p.S146S	HRH2_ENST00000377291.2_Silent_p.S146S	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	146					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	GGGTCATCTCCATTACCCTGT	0.557000													18	43					0	0	1	0	0
ZNF33A	7581	broad.mit.edu	37	10	38353019	38353019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:38353019C>T	ENST00000469037.2	+	6	533	c.391C>T	c.(391-393)Cct>Tct	p.P131S				Q06730	ZN33A_HUMAN	zinc finger protein 33A	58						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						CTCCCAGGCCCCTGAGATGCT	0.512000													44	95					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38997934	38997934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38997934G>A	ENST00000359357.3	+	91	13493	c.13239G>A	c.(13237-13239)cgG>cgA	p.R4413R	DNAH8_ENST00000441566.1_Silent_p.R4377R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GGGACAGACGGAATGGGAAGC	0.488000											OREG0017409	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	87					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226822414	226822414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226822414G>A	ENST00000429204.1	-	8	3126	c.2799C>T	c.(2797-2799)gtC>gtT	p.V933V	ITPKB_ENST00000272117.3_Silent_p.V933V	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	933							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				TCAGGATGTCGACGAGGTTAT	0.667000													14	26					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52605227	52605227	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52605227G>A	ENST00000591504.1	-	5	580	c.306C>T	c.(304-306)ctC>ctT	p.L102L	CCDC68_ENST00000337363.4_Silent_p.L102L|CCDC68_ENST00000432185.1_Silent_p.L102L	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	102										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TCATTTCTAAGAGCTGTAGGT	0.353000													5	47					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009273	9009273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9009273G>A	ENST00000397910.4	-	40	39403	c.39200C>T	c.(39199-39201)tCt>tTt	p.S13067F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13069	SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCACCTGAGAGAGATCAGTCT	0.507000													24	72					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250254	140250254	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140250254G>A	ENST00000398640.2	+	1	1566	c.1566G>A	c.(1564-1566)ttG>ttA	p.L522L	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGCCGTTGGACCACGAGG	0.682000													55	149					0	0	1	0	0
ARL6	84100	broad.mit.edu	37	3	97503890	97503890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97503890C>T	ENST00000463745.1	+	5	823	c.346C>T	c.(346-348)Cca>Tca	p.P116S	ARL6_ENST00000496713.1_3'UTR|ARL6_ENST00000394206.1_Missense_Mutation_p.P116S|ARL6_ENST00000335979.2_Missense_Mutation_p.P116S	NM_001278293.1	NP_001265222.1	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	116					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding			large_intestine(1)|lung(4)	5		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		TCTGAATCATCCAGGTATGTG	0.343000													15	74					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145001728	145001728	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145001728G>A	ENST00000322810.4	-	27	4186	c.4017C>T	c.(4015-4017)ctC>ctT	p.L1339L	PLEC_ENST00000356346.3_Silent_p.L1188L|PLEC_ENST00000357649.2_Silent_p.L1206L|PLEC_ENST00000436759.2_Silent_p.L1229L|PLEC_ENST00000527096.1_Silent_p.L1225L|PLEC_ENST00000398774.2_Silent_p.L1170L|PLEC_ENST00000345136.3_Silent_p.L1202L|PLEC_ENST00000354589.3_Silent_p.L1202L|PLEC_ENST00000354958.2_Silent_p.L1180L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1339	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCAGTTGCTCGAGCTCGCGCT	0.716000													3	10					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48596379	48596379	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48596379G>A	ENST00000323776.5	+	6	988	c.826G>A	c.(826-828)Gag>Aag	p.E276K	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.E239K	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	239					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GCACACCGGGGAGACCTACAG	0.582000													19	50					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14854482	14854482	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14854482G>A	ENST00000315576.3	-	19	2749	c.2298C>T	c.(2296-2298)atC>atT	p.I766I	EMR2_ENST00000392967.2_Silent_p.I755I|EMR2_ENST00000346057.1_Silent_p.I717I|EMR2_ENST00000596991.2_Silent_p.I755I|EMR2_ENST00000392965.3_Silent_p.I708I|EMR2_ENST00000594294.1_Silent_p.I717I|EMR2_ENST00000601345.1_Silent_p.I755I|EMR2_ENST00000594076.1_Silent_p.I673I|EMR2_ENST00000353876.1_Silent_p.I673I|EMR2_ENST00000353005.1_Silent_p.I624I|EMR2_ENST00000595839.1_Silent_p.I624I	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	766					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						GCAGGCTGTTGATGATGGTGA	0.607000													58	127					0	0	1	0	0
RCC2	55920	broad.mit.edu	37	1	17739641	17739641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17739641G>A	ENST00000375436.4	-	10	1428	c.1241C>T	c.(1240-1242)tCc>tTc	p.S414F	RCC2_ENST00000375433.3_Missense_Mutation_p.S414F	NM_018715.3	NP_061185.1	Q9P258	RCC2_HUMAN	regulator of chromosome condensation 2	414					cell division|mitotic prometaphase	chromosome, centromeric region|cytosol|microtubule|nucleolus|spindle				breast(2)|endometrium(1)|kidney(3)|large_intestine(7)|lung(4)	17		Colorectal(325;0.000147)|Breast(348;0.00122)|Renal(390;0.00145)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;7.69e-06)|COAD - Colon adenocarcinoma(227;1.19e-05)|Kidney(64;0.000189)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.0135)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)		AGATTCACGGGAGGTGTTGGT	0.542000													10	28					0	0	1	0	0
DCUN1D3	123879	broad.mit.edu	37	16	20873685	20873685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20873685G>A	ENST00000324344.3	-	2	461	c.176C>T	c.(175-177)gCc>gTc	p.A59V	DCUN1D3_ENST00000563934.1_Missense_Mutation_p.A59V|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3	59					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		GGCAGCCTCGGCCTTCTTGGT	0.597000													83	159					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7684729	7684729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7684729G>A	ENST00000358368.4	-	18	2447	c.2410C>T	c.(2410-2412)Cgg>Tgg	p.R804W	XAB2_ENST00000534844.1_Missense_Mutation_p.R801W	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	804					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						AGCTCCTCCCGGGAGGCGTCA	0.682000								Direct reversal of damage;Nucleotide excision repair (NER)					35	128					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56638912	56638912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56638912G>A	ENST00000267116.7	-	22	2588	c.2467C>T	c.(2467-2469)Ccc>Tcc	p.P823S		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	823							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						GGAGTGAAGGGGTTTCCTTCC	0.512000													10	159					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95263230	95263230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95263230C>T	ENST00000344604.5	-	9	1859	c.1710G>A	c.(1708-1710)cgG>cgA	p.R570R	CENPP_ENST00000375587.3_Intron|ECM2_ENST00000444490.2_Silent_p.R548R	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	570					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						AGCCAGGGATCCGTTCAATCT	0.483000													20	74					0	0	1	0	0
RBMS3	27303	broad.mit.edu	37	3	29628666	29628666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:29628666G>A	ENST00000434693.2	+	4	1066	c.366G>A	c.(364-366)aaG>aaA	p.K122K	RBMS3_ENST00000383767.2_Silent_p.K123K|RBMS3_ENST00000383766.2_Silent_p.K122K|RBMS3_ENST00000452462.1_Silent_p.K123K|RBMS3_ENST00000445033.1_Silent_p.K123K|RBMS3_ENST00000456853.1_Silent_p.K123K|RBMS3_ENST00000396583.3_Silent_p.K123K|RBMS3_ENST00000273139.9_Silent_p.K123K	NM_001003793.2	NP_001003793.1	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting protein 3	123	RRM 1.					cytoplasm	nucleotide binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	11		Ovarian(412;0.0956)				CATCTCTCAAGGCAAATGGCG	0.398000													5	81					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153133547	153133547	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153133547G>A	ENST00000370060.1	-	15	1923	c.1734C>T	c.(1732-1734)atC>atT	p.I578I	L1CAM_ENST00000361981.3_Silent_p.I573I|L1CAM_ENST00000370055.1_Silent_p.I573I|L1CAM_ENST00000370057.3_Silent_p.I578I|L1CAM_ENST00000361699.4_Silent_p.I578I|L1CAM_ENST00000543994.1_Silent_p.I580I|L1CAM_ENST00000538883.1_Silent_p.I580I	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	578	Ig-like C2-type 6.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGGCTGTGGATGACCAGGC	0.597000													7	33					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27289779	27289779	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27289779C>T	ENST00000397501.1	+	15	1696	c.888C>T	c.(886-888)ccC>ccT	p.P296P	PTK2B_ENST00000397497.4_Silent_p.P42P|PTK2B_ENST00000544172.1_Silent_p.P296P|PTK2B_ENST00000338238.4_Silent_p.P296P|PTK2B_ENST00000420218.2_Silent_p.P296P|PTK2B_ENST00000346049.5_Silent_p.P296P|PTK2B_ENST00000517339.1_Silent_p.P296P	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	296	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TCCCACAGCCCACCTGCCTGG	0.622000													8	23					0	0	1	0	0
FBLIM1	54751	broad.mit.edu	37	1	16097048	16097048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16097048G>A	ENST00000375766.3	+	6	1326	c.686G>A	c.(685-687)cGa>cAa	p.R229Q	FBLIM1_ENST00000441801.2_Missense_Mutation_p.R229Q|FBLIM1_ENST00000400773.1_Missense_Mutation_p.R132Q|FBLIM1_ENST00000375771.1_Missense_Mutation_p.R229Q|FBLIM1_ENST00000332305.5_Missense_Mutation_p.R132Q	NM_017556.2	NP_060026.2	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	229	LIM zinc-binding 1.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		AAGGATGGGCGACCCCTCTGC	0.607000													16	39					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21249714	21249714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21249714G>A	ENST00000233242.1	-	15	2317	c.2190C>T	c.(2188-2190)gtC>gtT	p.V730V	APOB_ENST00000399256.4_Silent_p.V730V	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	730			V -> I (in dbSNP:rs12691202).		cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGACCTTAGAGACACCATCAG	0.413000													33	96					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551632	35551632	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35551632G>A	ENST00000262626.2	+	9	1547	c.722G>A	c.(721-723)gGg>gAg	p.G241E	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Missense_Mutation_p.G83E|HPN_ENST00000392226.1_Missense_Mutation_p.G241E	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	241	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GTCTACCACGGGGGCTATCTT	0.642000													25	75					0	0	1	0	0
TUBA4B	80086	broad.mit.edu	37	2	220136346	220136346	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220136346G>A	ENST00000490341.1	+	0	816					NR_003063.1																						CATCTCTGCAGAAAAGGTATA	0.557000													15	83					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84438821	84438821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84438821G>A	ENST00000416219.2	+	3	387	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	ATP2C2_ENST00000262429.4_Missense_Mutation_p.E100K			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	100					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						TGACAACAGCGAACCTGTGTG	0.547000													5	42					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118228010	118228010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:118228010C>T	ENST00000402510.2	-	9	1315	c.1316G>A	c.(1315-1317)gGa>gAa	p.G439E		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	439										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CTGCAGGGATCCCTCTAAAAT	0.473000													24	20					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61053825	61053825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61053825G>A	ENST00000335613.5	-	5	888	c.502C>T	c.(502-504)Ccg>Tcg	p.P168S		NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	168	EGF-like 2; calcium-binding (Potential).					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TGCATGCCCGGCCCACACTCG	0.572000													75	139					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49897923	49897923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49897923C>T	ENST00000477224.1	-	9	1313	c.835G>A	c.(835-837)Gag>Aag	p.E279K	CAMKV_ENST00000488336.1_Missense_Mutation_p.E279K|CAMKV_ENST00000463537.1_Missense_Mutation_p.E279K|CAMKV_ENST00000296471.7_Missense_Mutation_p.E251K|CAMKV_ENST00000467248.1_Missense_Mutation_p.E204K|CAMKV_ENST00000466940.1_Missense_Mutation_p.E236K			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	279	Protein kinase.		E -> D (in dbSNP:rs56071455).			cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GAGATGGCCTCTTCTGCAGTG	0.612000													4	21					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138202199	138202199	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:138202199C>T	ENST00000237289.4	+	9	2182	c.2116C>T	c.(2116-2118)Cga>Tga	p.R706*		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	706	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		AGATGTGCCTCGAACCACACA	0.542000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								18	55					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454440	84454440	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:84454440G>A	ENST00000377084.2	-	1	2088	c.1203C>T	c.(1201-1203)ctC>ctT	p.L401L		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	401						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCAACAGAATGAGGTTCTTGT	0.438000													92	267					0	0	1	0	0
SAP130	79595	broad.mit.edu	37	2	128775310	128775310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128775310G>A	ENST00000357702.5	-	3	501	c.370C>T	c.(370-372)Ccg>Tcg	p.P124S	SAP130_ENST00000259234.6_Missense_Mutation_p.P98S|SAP130_ENST00000259235.3_Missense_Mutation_p.P124S	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	124	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TGTGCTGGCGGGGCTGTCACT	0.537000													8	75					0	0	1	0	0
NR1I2	8856	broad.mit.edu	37	3	119535955	119535955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119535955C>T	ENST00000393716.2	+	9	3040	c.1201C>T	c.(1201-1203)Cgc>Tgc	p.R401C	NR1I2_ENST00000337940.4_Missense_Mutation_p.R440C|NR1I2_ENST00000466380.1_Missense_Mutation_p.R364C	NM_003889.3	NP_003880.3	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	401	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	CACCGAGCTCCGCAGCATCAA	0.582000													37	64					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34269257	34269257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:34269257G>A	ENST00000346562.2	+	11	1722	c.1648G>A	c.(1648-1650)Gac>Aac	p.D550N	NPAS3_ENST00000357798.5_Missense_Mutation_p.D569N|NPAS3_ENST00000548645.1_Missense_Mutation_p.D552N|NPAS3_ENST00000356141.4_Missense_Mutation_p.D582N|NPAS3_ENST00000551492.1_Missense_Mutation_p.D587N	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	582					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CAGCGCCAAGGACTCGGACAG	0.672000													6	15					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111184	7111184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7111184C>T	ENST00000306904.5	+	1	1020	c.833C>T	c.(832-834)tCc>tTc	p.S278F		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	278	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCAGAGGCTCCCATCGAGAG	0.657000													23	42					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882455	144882455	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:144882455A>G	ENST00000369359.4	-	27	4013	c.3975T>C	c.(3973-3975)gaT>gaC	p.D1325D	PDE4DIP_ENST00000369354.3_Silent_p.D1188D|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000530740.1_Silent_p.D1325D|PDE4DIP_ENST00000369356.4_Silent_p.D1188D|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1188					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTTGGTGGGCATCCACTGTGA	0.502000			T	PDGFRB	MPD								13	71					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123929839	123929839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123929839G>A	ENST00000373855.1	+	37	5988	c.5728G>A	c.(5728-5730)Gaa>Aaa	p.E1910K	CNTRL_ENST00000373850.1_Missense_Mutation_p.E1358K|CNTRL_ENST00000238341.5_Missense_Mutation_p.E1910K|CNTRL_ENST00000373845.2_3'UTR			Q7Z7A1	CNTRL_HUMAN	centriolin	1910					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GGACATCAGTGAATGGGCAAA	0.433000													18	39					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3432637	3432637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3432637C>T	ENST00000336727.3	+	17	4973	c.4069C>T	c.(4069-4071)Ccg>Tcg	p.P1357S	RGS12_ENST00000538395.1_3'UTR|RGS12_ENST00000344733.5_Missense_Mutation_p.P1357S|RGS12_ENST00000338806.4_Missense_Mutation_p.P709S|RGS12_ENST00000382788.3_Missense_Mutation_p.P1357S	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1357						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CACCTTGCTGCCGCCGCCCTC	0.667000													14	34					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187261	140187261	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140187261G>A	ENST00000530339.1	+	1	489	c.489G>A	c.(487-489)ggG>ggA	p.G163G	PCDHA4_ENST00000512229.2_Silent_p.G163G|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.G163G|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATATCGGGGAGAACGCCC	0.522000													31	87					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183107490	183107490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183107490G>A	ENST00000328913.3	-	2	451	c.154C>T	c.(154-156)Ctt>Ttt	p.L52F	MCF2L2_ENST00000414362.2_Missense_Mutation_p.L52F|MCF2L2_ENST00000447025.2_Missense_Mutation_p.L52F|MCF2L2_ENST00000473233.1_Missense_Mutation_p.L52F	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	52	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TTACCTGAAAGAATGGCAAAT	0.433000													13	60					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56096685	56096685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56096685G>A	ENST00000257880.7	-	3	604	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	ITGA7_ENST00000347027.6_Missense_Mutation_p.R129W|ITGA7_ENST00000394230.2_Missense_Mutation_p.R129W|ITGA7_ENST00000452168.2_Intron|ITGA7_ENST00000553804.1_Missense_Mutation_p.R129W|ITGA7_ENST00000555728.1_Missense_Mutation_p.R129W|ITGA7_ENST00000394229.2_Missense_Mutation_p.R129W|ITGA7_ENST00000257879.6_Missense_Mutation_p.R129W			Q13683	ITA7_HUMAN	integrin, alpha 7	129					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity	p.R129W(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCCTGGCTCCGAACACTGACT	0.522000													15	82					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52965784	52965784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52965784C>T	ENST00000549343.1	-	3	729	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K	KRT74_ENST00000305620.2_Missense_Mutation_p.E231K			Q7RTS7	K2C74_HUMAN	keratin 74	231	Coil 1B.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		ATCTCCACTTCATATCTGCCA	0.537000													14	104					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26988280	26988280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:26988280C>T	ENST00000231021.4	-	2	333	c.161G>A	c.(160-162)gGc>gAc	p.G54D		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	54	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CCACATCCAGCCACGCTTGGT	0.388000													16	38					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50154532	50154532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50154532C>T	ENST00000360565.3	+	7	1010	c.886C>T	c.(886-888)Cgc>Tgc	p.R296C		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	296					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GAGCATCAGCCGCATCTCGGA	0.642000													14	23					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171323129	171323129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171323129G>A	ENST00000334231.6	+	25	2949	c.2949G>A	c.(2947-2949)ctG>ctA	p.L983L	MYO3B_ENST00000409044.3_Silent_p.L974L|MYO3B_ENST00000602629.1_Intron|MYO3B_ENST00000408978.4_Silent_p.L974L			Q8WXR4	MYO3B_HUMAN	myosin IIIB	974	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						AGAGGGTGCTGGCCCAGCTCC	0.557000													35	121					0	0	1	0	0
TRIM16L	147166	broad.mit.edu	37	17	18638769	18638769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18638769C>T	ENST00000449552.2	+	7	2527	c.1043C>T	c.(1042-1044)cCc>cTc	p.P348L	TRIM16L_ENST00000395672.2_Missense_Mutation_p.P348L|TRIM16L_ENST00000571708.1_Missense_Mutation_p.P348L|TRIM16L_ENST00000395902.3_Missense_Mutation_p.P402L|TRIM16L_ENST00000395671.4_Missense_Mutation_p.P348L|TRIM16L_ENST00000572555.1_Missense_Mutation_p.P348L			Q309B1	TR16L_HUMAN	tripartite motif containing 16-like	348						cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	9						GGGACTGCTCCCTAGACTCCA	0.522000													5	17					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10468287	10468287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10468287C>T	ENST00000382483.3	-	4	3544	c.3321G>A	c.(3319-3321)atG>atA	p.M1107I		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1107					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GCCTCCTGGCCATGGGCCTAG	0.627000													25	104					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940539	22940539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22940539C>T	ENST00000397104.3	-	5	1898	c.1899G>A	c.(1897-1899)gaG>gaA	p.E633E	ZNF99_ENST00000596209.1_Silent_p.E724E					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATGAATTATCTCATGTTTTC	0.363000													24	70					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919366	4919366	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4919366G>A	ENST00000433855.1	+	1	1025	c.159G>A	c.(157-159)gaG>gaA	p.E53E	KCNA6_ENST00000280684.3_Silent_p.E53E	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	53						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						TGCGCTTTGAGACACAATTGC	0.642000										HNSCC(72;0.22)			31	47					0	0	1	0	0
LYZL2	119180	broad.mit.edu	37	10	30918621	30918621	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30918621G>C	ENST00000375318.2	-	1	70	c.14C>G	c.(13-15)cCc>cGc	p.P5R		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	0					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				GCAGCTCAGGGGAGCGTCCTG	0.502000													8	44					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48915876	48915876	+	Missense_Mutation	SNP	C	C	T	rs121912529		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48915876C>T	ENST00000294954.7	-	11	1081	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	LHCGR_ENST00000405626.1_Missense_Mutation_p.E327K|LHCGR_ENST00000403273.1_Intron|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000344775.3_Missense_Mutation_p.E292K|LHCGR_ENST00000401907.1_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	354			E -> K (in LHR; Leydig cell hypoplasia type 1).		male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	ATAATATCTTCACAGGGATTA	0.443000													25	135					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123038613	123038613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123038613G>A	ENST00000462833.1	-	10	3376	c.2164C>T	c.(2164-2166)Cgt>Tgt	p.R722C	ADCY5_ENST00000309879.5_Missense_Mutation_p.R372C|ADCY5_ENST00000491190.1_Missense_Mutation_p.R355C	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	722					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TCAATGGCACGGCCCAGAAAC	0.592000													11	36					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803019	54803019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54803019G>A	ENST00000391745.1	-	8	1025	c.709C>T	c.(709-711)Cca>Tca	p.P237S	LILRA3_ENST00000391744.3_Intron|LILRA3_ENST00000251390.3_Missense_Mutation_p.P220S					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTCTCACCTGGGACCAGGAGC	0.612000													35	101					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118230488	118230488	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:118230488G>A	ENST00000402510.2	-	8	1234	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	412										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TTGTTTGCGGGGATTTAAAGT	0.468000													13	14					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968393	28968393	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28968393C>T	ENST00000359747.4	+	4	309	c.280C>T	c.(280-282)Cga>Tga	p.R94*	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Nonsense_Mutation_p.R94*|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	94	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGGGATTGATCGACCACCATA	0.408000													16	64					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14341131	14341131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:14341131C>T	ENST00000571589.1	+	12	2186	c.2014C>T	c.(2014-2016)Ctt>Ttt	p.L672F	MKL2_ENST00000574045.1_Missense_Mutation_p.L672F|MKL2_ENST00000318282.5_Missense_Mutation_p.L672F|MKL2_ENST00000341243.5_Missense_Mutation_p.L661F	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	661	Gln-rich.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TGGCCAGACCCTTGTTGCCAA	0.582000													28	51					0	0	1	0	0
OR2A14	135941	broad.mit.edu	37	7	143827007	143827007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143827007G>A	ENST00000408899.2	+	1	857	c.802G>A	c.(802-804)Gag>Aag	p.E268K		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					CCATCCTGAGGAGCAGCAGAA	0.542000													65	173					0	0	1	0	0
OR8B8	26493	broad.mit.edu	37	11	124310178	124310178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124310178C>T	ENST00000328064.2	-	1	876	c.804G>A	c.(802-804)atG>atA	p.M268I		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGCCCTGGTTCATAGCTAAAA	0.453000													25	48					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41552569	41552569	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41552569C>T	ENST00000373060.1	+	4	821	c.363C>T	c.(361-363)atC>atT	p.I121I	FOXP4_ENST00000373063.3_Silent_p.I121I|FOXP4_ENST00000373057.3_Silent_p.I121I|FOXP4_ENST00000409208.1_Silent_p.I121I|FOXP4_ENST00000307972.4_Silent_p.I121I	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	121	Gln-rich.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					TGCAGCAGATCCTGTCGCCCC	0.662000													9	22					0	0	1	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789314	140789314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140789314C>T	ENST00000520790.1	+	1	1545	c.1545C>T	c.(1543-1545)ttC>ttT	p.F515F	PCDHGA8_ENST00000398604.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGTGTTCGCGCAGCGCG	0.667000													4	23					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45936027	45936027	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45936027G>A	ENST00000374391.2	+	8	1184	c.1131G>A	c.(1129-1131)gaG>gaA	p.E377E	ALOX5_ENST00000542434.1_Silent_p.E377E	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	377	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	TGGTGTCTGAGGTTTTTGGCA	0.542000													17	38					0	0	1	0	0
RNF180	285671	broad.mit.edu	37	5	63509401	63509401	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:63509401G>A	ENST00000389100.4	+	4	320	c.248G>A	c.(247-249)gGa>gAa	p.G83E	RNF180_ENST00000296615.6_Missense_Mutation_p.G83E|RNF180_ENST00000381081.2_Intron	NM_001113561.1	NP_001107033.1	Q86T96	RN180_HUMAN	ring finger protein 180	83						integral to membrane|nuclear envelope	zinc ion binding			breast(1)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	20		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		TGGACAGTTGGAAAACTGAAT	0.418000													80	183					0	0	1	0	0
RNASEH2B	79621	broad.mit.edu	37	13	51522143	51522143	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:51522143C>A	ENST00000336617.3	+	8	1036	c.637C>A	c.(637-639)Cat>Aat	p.H213N	RNASEH2B_ENST00000422660.1_Missense_Mutation_p.H213N|RNASEH2B_ENST00000495244.2_3'UTR	NM_024570.3	NP_078846.2	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B	213					RNA catabolic process	nucleus|ribonuclease H2 complex				endometrium(2)|liver(1)|lung(1)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		TCGTTATGCCCATGGTCTGAT	0.308000													43	173					4.00472e-15	4.02569e-15	1	1	0
C3orf67	200844	broad.mit.edu	37	3	58849567	58849567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58849567C>T	ENST00000472469.1	-	11	1494	c.656G>A	c.(655-657)aGc>aAc	p.S219N	RP11-147N17.1_ENST00000482372.1_RNA|C3orf67_ENST00000295966.7_Missense_Mutation_p.S312N|RP11-147N17.1_ENST00000492031.1_RNA|RP11-147N17.1_ENST00000463703.1_RNA|C3orf67_ENST00000482387.1_Missense_Mutation_p.S312N|RP11-147N17.1_ENST00000493123.1_RNA			Q6ZVT6	CC067_HUMAN	chromosome 3 open reading frame 67	312										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		AGACTGTCTGCTGGATGCCAG	0.453000													16	58					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95932532	95932532	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95932532G>A	ENST00000334258.5	-	3	377	c.363C>T	c.(361-363)gcC>gcT	p.A121A	SYNE3_ENST00000557275.1_Silent_p.A121A|SYNE3_ENST00000553340.1_Silent_p.A121A	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3									p.A121A(1)		breast(1)|endometrium(2)|lung(25)	28						ACTCATCTCGGGCCAGCAGGT	0.617000													19	102					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101765751	101765751	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101765751G>A	ENST00000334289.3	-	8	1301	c.706C>T	c.(706-708)Cag>Tag	p.Q236*		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	236	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		GTATTTTTCTGATTTACTATA	0.284000													16	55					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89128865	89128865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:89128865C>T	ENST00000286614.6	-	6	1235	c.954G>A	c.(952-954)agG>agA	p.R318R	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	318					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						TGTCATTTTTCCTTGGGTCAG	0.527000													50	118					0	0	1	0	0
EEA1	8411	broad.mit.edu	37	12	93244932	93244932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:93244932G>A	ENST00000322349.8	-	9	1017	c.753C>T	c.(751-753)ctC>ctT	p.L251L		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	251					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						ATTCATCTTTGAGTTTTTCAG	0.368000													17	59					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951748	119951748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119951748C>T	ENST00000307142.4	+	4	2014	c.1818C>T	c.(1816-1818)acC>acT	p.T606T	SYNPO2_ENST00000429713.2_Silent_p.T606T|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Silent_p.T606T	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	606	Pro-rich.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TCTCGCCAACCCGAAACATGA	0.557000													33	135					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402533	248402533	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248402533A>C	ENST00000306687.1	+	1	303	c.303A>C	c.(301-303)atA>atC	p.I101I		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GAACTCAGATATTCTTCTATG	0.463000													39	84					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65789296	65789296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65789296G>A	ENST00000312106.5	-	3	1621	c.1484C>T	c.(1483-1485)gCc>gTc	p.A495V		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	495					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CTTGAGCAGGGCTTCCACCAC	0.572000													14	103					0	0	1	0	0
TRAV8-2	28684	broad.mit.edu	37	14	22315315	22315315	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22315315G>A	ENST00000390434.3	+	0	478																											TTTTGAGGCTGAATTTAAGAA	0.502000											OREG0022570	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	61	141					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21687424	21687424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:21687424C>T	ENST00000398485.2	+	2	689	c.635C>T	c.(634-636)cCt>cTt	p.P212L	PAX1_ENST00000444366.2_Missense_Mutation_p.P188L|PAX1_ENST00000460221.1_Intron	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	212	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						TACAATGTGCCTTCGGTGAGC	0.632000													45	72					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82416145	82416145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:82416145C>T	ENST00000370728.1	+	9	2116	c.1471C>T	c.(1471-1473)Cca>Tca	p.P491S	LPHN2_ENST00000370723.1_Missense_Mutation_p.P491S|LPHN2_ENST00000335786.5_Missense_Mutation_p.P491S|LPHN2_ENST00000370715.1_Missense_Mutation_p.P491S|LPHN2_ENST00000370725.1_Missense_Mutation_p.P491S|LPHN2_ENST00000359929.3_Missense_Mutation_p.P491S|LPHN2_ENST00000394879.1_Missense_Mutation_p.P491S|LPHN2_ENST00000370727.1_Missense_Mutation_p.P491S|LPHN2_ENST00000370730.1_Missense_Mutation_p.P491S|LPHN2_ENST00000370717.2_Missense_Mutation_p.P491S|LPHN2_ENST00000319517.6_Missense_Mutation_p.P491S|LPHN2_ENST00000370713.1_Missense_Mutation_p.P491S|LPHN2_ENST00000370721.1_Missense_Mutation_p.P429S|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000271029.4_Missense_Mutation_p.P491S			O95490	LPHN2_HUMAN	latrophilin 2	491					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GGTTGAACGACCATGCCCTAA	0.378000													22	68					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7619939	7619939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7619939C>T	ENST00000221249.6	+	25	3112	c.2681C>T	c.(2680-2682)tCg>tTg	p.S894L	PNPLA6_ENST00000600737.1_Missense_Mutation_p.S932L|PNPLA6_ENST00000545201.2_Missense_Mutation_p.S867L|PNPLA6_ENST00000450331.3_Missense_Mutation_p.S894L|PNPLA6_ENST00000414982.3_Missense_Mutation_p.S942L	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	933					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						CGCCTCTTTTCGCGCCGCAGC	0.731000													6	8					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121630439	121630439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121630439C>T	ENST00000489711.1	+	4	742	c.354C>T	c.(352-354)tcC>tcT	p.S118S	SLC15A2_ENST00000295605.2_Intron	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	118					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TCTATCTCTCCTTGGTGTATG	0.418000													15	43					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119441727	119441727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119441727C>T	ENST00000369429.3	-	7	957	c.948G>A	c.(946-948)atG>atA	p.M316I	TBX15_ENST00000207157.3_Missense_Mutation_p.M210I			Q96SF7	TBX15_HUMAN	T-box 15	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CATATGTCTCCATGATGGCTT	0.468000													18	44					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148627436	148627436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148627436C>T	ENST00000506113.1	+	17	2125	c.1643C>T	c.(1642-1644)tCc>tTc	p.S548F	RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000517451.1_Missense_Mutation_p.S34F|AC012613.2_ENST00000523176.1_RNA|ABLIM3_ENST00000326685.7_Missense_Mutation_p.S453F|ABLIM3_ENST00000356541.3_Missense_Mutation_p.S437F|ABLIM3_ENST00000504238.1_Missense_Mutation_p.S437F|ABLIM3_ENST00000309868.7_Missense_Mutation_p.S548F|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000508983.1_Missense_Mutation_p.S515F			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	548					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGGAGCTCCACCAGCAGC	0.602000													6	31					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580266	140580266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580266C>T	ENST00000354757.3	+	1	919	c.919C>T	c.(919-921)Ctg>Ttg	p.L307L	PCDHB11_ENST00000536699.1_5'UTR	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		307	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGAGCACCTCTGGATTTTGA	0.358000													45	78					0	0	1	0	0
CELA3A	10136	broad.mit.edu	37	1	22332005	22332005	+	Silent	SNP	C	C	T	rs150719625		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22332005C>T	ENST00000290122.3	+	3	214	c.195C>T	c.(193-195)ccC>ccT	p.P65P	CELA3A_ENST00000374663.1_Silent_p.P65P	NM_005747.4	NP_005738.4			chymotrypsin-like elastase family, member 3A											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCATCGCCCCCGATTGGGTTG	0.617000											OREG0013211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	118					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177190142	177190142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:177190142G>A	ENST00000296525.3	-	1	231	c.118C>T	c.(118-120)Cat>Tat	p.H40Y		NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	40					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		ATGTAGAAATGACTGAGGATG	0.403000													26	46					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52356612	52356612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52356612C>T	ENST00000420323.2	+	2	415	c.154C>T	c.(154-156)Cct>Tct	p.P52S		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	52	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTTGGGAAATCCTCCAGCCCT	0.607000													17	54					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114267166	114267166	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114267166G>A	ENST00000357077.4	+	35	4412	c.4359G>A	c.(4357-4359)ccG>ccA	p.P1453P	ANK2_ENST00000509550.1_Silent_p.P629P|ANK2_ENST00000264366.6_Silent_p.P1420P|ANK2_ENST00000506722.1_Silent_p.P1444P|ANK2_ENST00000394537.3_Silent_p.P1453P|ANK2_ENST00000510275.2_Silent_p.P105P	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1420					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.P1453P(2)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCACTTTGCCGATTTATACAA	0.393000													14	99					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51893112	51893112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51893112C>T	ENST00000371117.3	-	30	3677	c.3402G>A	c.(3400-3402)atG>atA	p.M1134I	PKHD1_ENST00000340994.4_Missense_Mutation_p.M1134I	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1134	IPT/TIG 6; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCGTATAGTTCATCAGCCTCG	0.562000													25	86					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49958711	49958711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:49958711G>A	ENST00000376056.2	-	5	776	c.626C>T	c.(625-627)tCc>tTc	p.S209F	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000358526.2_Missense_Mutation_p.S218F|AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000376064.3_Missense_Mutation_p.S209F			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	218					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					GACGTAGAAGGAAAGGTCATC	0.438000													84	36					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86196269	86196269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86196269C>T	ENST00000370571.2	-	60	5471	c.5105G>A	c.(5104-5106)cGa>cAa	p.R1702Q	COL24A1_ENST00000436319.1_Missense_Mutation_p.R1681Q	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1702	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent	p.R1702Q(1)		NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTAATACTTTCGTTCAGTTTT	0.413000													32	82					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18671987	18671987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18671987C>T	ENST00000308799.4	+	9	2151	c.1932C>T	c.(1930-1932)ccC>ccT	p.P644P	FBXW10_ENST00000395667.1_Silent_p.P615P|FBXW10_ENST00000301938.4_Silent_p.P615P|FBXW10_ENST00000395665.4_Silent_p.P615P			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	615										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						TCAAGCATCCCAAGTAGGTGC	0.572000													24	16					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115487056	115487056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115487056G>A	ENST00000369522.3	+	24	2263	c.2023G>A	c.(2023-2025)Gaa>Aaa	p.E675K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E675K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	675					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGATATCAGAAGAAAATCT	0.274000													16	60					0	0	1	0	0
GSTK1	373156	broad.mit.edu	37	7	142962297	142962297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142962297C>T	ENST00000479303.1	+	4	554	c.496C>T	c.(496-498)Ctc>Ttc	p.L166F	AC073342.12_ENST00000427392.1_RNA|GSTK1_ENST00000409500.3_Intron|GSTK1_ENST00000443571.2_Intron|GSTK1_ENST00000358406.5_Intron	NM_001143679.1	NP_001137151.1	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1	138						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity			lung(4)	4	Melanoma(164;0.059)				Glutathione(DB00143)	ATCTACTGTCCTCCCAGTCAC	0.602000													5	8					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101748315	101748315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101748315C>T	ENST00000375001.3	+	3	992	c.569C>T	c.(568-570)tCc>tTc	p.S190F		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	190	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				TTCCAGCGGTCCTCCCAGGCT	0.567000													24	49					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70535554	70535554	+	Missense_Mutation	SNP	C	C	T	rs112767369		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:70535554C>T	ENST00000377844.4	-	3	1462	c.703G>A	c.(703-705)Gac>Aac	p.D235N	KLHL1_ENST00000545028.1_Missense_Mutation_p.D42N	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	235	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GCAAAATAGTCGGAGACTGAA	0.448000													8	64					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83631363	83631363	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83631363C>T	ENST00000265362.3	-	12	1675		c.e12-1		SEMA3A_ENST00000436949.1_Splice_Site	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A						axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						GTCCCAACATCTTTGAAAGAA	0.373000													15	35					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19067962	19067962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19067962C>T	ENST00000421369.3	+	14	2198	c.1640C>T	c.(1639-1641)tCc>tTc	p.S547F	TMC7_ENST00000304381.5_Missense_Mutation_p.S657F|TMC7_ENST00000569532.1_Missense_Mutation_p.S657F	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	657						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						TCGCTGCAGTCCTTCATCCAT	0.557000													40	89					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98155766	98155766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98155766C>T	ENST00000357947.3	-	12	1621	c.1396G>A	c.(1396-1398)Gga>Aga	p.G466R	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	466	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TTCATGTCTCCCCCGCAGGTA	0.537000											OREG0020398	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	79					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711094	58711094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58711094G>A	ENST00000300079.5	+	2	153	c.103G>A	c.(103-105)Gat>Aat	p.D35N	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_5'UTR	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	gtacctgcaggatccaattgt	0.473000													14	43					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114274902	114274902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114274902G>A	ENST00000357077.4	+	38	5181	c.5128G>A	c.(5128-5130)Gaa>Aaa	p.E1710K	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.E1677K|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1677					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAAATTAAAAGAAAAGCAGAA	0.398000													23	166					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179432393	179432393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179432393C>T	ENST00000589042.1	-	326	78690	c.78466G>A	c.(78466-78468)Gat>Aat	p.D26156N	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D23588N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D24515N|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D17283N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D17216N|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D17091N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24515	Fibronectin type-III 90.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTTTGATCTTCAGTAAGA	0.398000													20	50					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83817025	83817025	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:83817025C>T	ENST00000566620.1	+	13	2372	c.2082C>T	c.(2080-2082)gcC>gcT	p.A694A	CDH13_ENST00000428848.3_Silent_p.A655A|CDH13_ENST00000268613.10_Silent_p.A741A	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	694	Cadherin 5.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CGGCAGGGGCCCTGCGCTTCA	0.517000													7	68					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73836847	73836847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73836847G>A	ENST00000207549.4	-	8	1058	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C	UNC13D_ENST00000412096.2_Missense_Mutation_p.R227C|UNC13D_ENST00000587504.1_5'UTR	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	227					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGAACCTGCGAAGCCCATGC	0.597000									Familial Hemophagocytic Lymphohistiocytosis				40	134					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122854194	122854194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122854194G>A	ENST00000379645.3	-	2	292	c.219C>T	c.(217-219)tcC>tcT	p.S73S	TRPC3_ENST00000264811.5_5'UTR	NM_001130698.1	NP_001124170.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	0					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TTCCCTCCATGGACCTAATCA	0.547000													6	46					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156283289	156283289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156283289G>A	ENST00000311277.4	-	6	976	c.713C>T	c.(712-714)tCa>tTa	p.S238L	AC097467.2_ENST00000596165.1_RNA|AC097467.2_ENST00000594666.1_RNA|MAP9_ENST00000515654.1_Missense_Mutation_p.S238L|AC097467.2_ENST00000594492.1_RNA|AC097467.2_ENST00000597831.1_RNA|AC097467.2_ENST00000600928.1_RNA|AC097467.2_ENST00000598890.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	238					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TGTTAAGCATGAATCCTGTTT	0.318000													26	59					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48762084	48762084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48762084C>T	ENST00000285238.8	+	29	4208	c.4128C>T	c.(4126-4128)ttC>ttT	p.F1376F		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1376	ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCATCCTGTTCTCGGGGACCC	0.602000													25	90					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17419886	17419886	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17419886C>T	ENST00000302539.4	-	30	3881	c.3756_splice	c.e30+1	p.M1252_splice	ABCC8_ENST00000389817.3_Splice_Site_p.M1251_splice	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1251	ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TAGCACTTGCCATTCGGACTT	0.542000													11	44					0	0	1	0	0
RHOD	29984	broad.mit.edu	37	11	66834233	66834233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66834233G>A	ENST00000308831.2	+	3	330	c.245G>A	c.(244-246)cGg>cAg	p.R82Q	RHOD_ENST00000532559.1_Intron|RHOD_ENST00000533360.1_Missense_Mutation_p.R82Q	NM_014578.3	NP_055393.1	O00212	RHOD_HUMAN	ras homolog family member D	82					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			lung(3)	3						GACCGCCTGCGGCCCCTGTTC	0.607000													76	126					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131733085	131733085	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131733085C>T	ENST00000372577.2	+	11	982	c.961C>T	c.(961-963)Cca>Tca	p.P321S		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	321					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						ACATCATGCCCCAGTGCTTTT	0.483000													27	79					0	0	1	0	0
OR5K3	403277	broad.mit.edu	37	3	98110041	98110041	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98110041T>A	ENST00000383695.1	+	1	532	c.532T>A	c.(532-534)Ttc>Atc	p.F178I	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005516.1	NP_001005516.1	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K, member 3	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|prostate(1)|skin(1)|urinary_tract(1)	27						CAATCATTTTTTCTGTGATGT	0.363000													33	93					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179561838	179561838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179561838G>A	ENST00000444136.1	+	2	338	c.88G>A	c.(88-90)Gag>Aag	p.E30K	TDRD5_ENST00000367614.1_Missense_Mutation_p.E30K|TDRD5_ENST00000294848.8_Missense_Mutation_p.E30K	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	30	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GAGCCCACAGGAGTTGGAGAA	0.483000													41	126					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43778950	43778950	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43778950G>A	ENST00000405006.4	-	19	3276	c.2925C>T	c.(2923-2925)ctC>ctT	p.L975L	THADA_ENST00000330266.7_Silent_p.L685L|THADA_ENST00000415080.2_Silent_p.L685L|THADA_ENST00000405975.2_Silent_p.L975L	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	975							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CCATTGGGATGAGGCCTTCAG	0.468000													12	57					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78846279	78846279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:78846279G>A	ENST00000286627.5	-	11	2359	c.1407C>T	c.(1405-1407)tcC>tcT	p.S469S	KCNMA1_ENST00000372440.1_Silent_p.S469S|KCNMA1_ENST00000354353.5_Silent_p.S469S|KCNMA1_ENST00000404857.1_Silent_p.S469S|KCNMA1_ENST00000406533.3_Silent_p.S469S|KCNMA1_ENST00000286628.8_Silent_p.S469S|KCNMA1_ENST00000404771.3_Silent_p.S469S|KCNMA1_ENST00000372443.1_Silent_p.S469S	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	469	RCK N-terminal.				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GATTGAGGACGGAACCCTGAT	0.478000													20	56					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46797136	46797136	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46797136G>T	ENST00000230588.4	+	10	981	c.972G>T	c.(970-972)gcG>gcT	p.A324A		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	324	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			CGGGGTCCGCGGAAGAGGCAG	0.537000													37	136					1.30998e-17	1.31743e-17	1	1	0
SEMA6B	10501	broad.mit.edu	37	19	4544371	4544371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4544371C>T	ENST00000586582.1	-	17	2219	c.1909G>A	c.(1909-1911)Gag>Aag	p.E637K	SEMA6B_ENST00000301293.3_Missense_Mutation_p.E637K|SEMA6B_ENST00000586965.1_Intron	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	637					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGATGGCCTCCTTGTCCTTG	0.776000													6	9					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126398443	126398443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126398443C>T	ENST00000394329.3	+	13	12440	c.12427C>T	c.(12427-12429)Cct>Tct	p.P4143S	FAT4_ENST00000335110.5_Missense_Mutation_p.P2406S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4143	Laminin G-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAATGGAAGGCCTCTGGAACC	0.413000													52	139					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53223903	53223903	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53223903C>T	ENST00000330553.5	-	4	794		c.e4-1			NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79							keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CATCCACATCCTGGGGACGAG	0.582000													19	51					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203420441	203420441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:203420441C>T	ENST00000374580.4	+	12	2592	c.2053C>T	c.(2053-2055)Ctc>Ttc	p.L685F	BMPR2_ENST00000374574.2_Intron	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	685					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						TGATGAGAATCTCATGGAGCA	0.448000													18	81					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159860290	159860290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159860290C>T	ENST00000368099.4	-	3	316	c.252G>A	c.(250-252)cgG>cgA	p.R84R	CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000426543.2_5'UTR	NM_012337.2	NP_036469.2	Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	84						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			GGACCATGTCCCGGGTGATGA	0.522000													18	129					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76790610	76790610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76790610C>T	ENST00000287239.4	+	18	6517	c.6028C>T	c.(6028-6030)Cat>Tat	p.H2010Y	KAT6B_ENST00000372714.1_Missense_Mutation_p.H1718Y|KAT6B_ENST00000372725.1_Missense_Mutation_p.H1718Y|KAT6B_ENST00000372711.1_Missense_Mutation_p.H1827Y|KAT6B_ENST00000372724.1_Missense_Mutation_p.H1718Y	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	2010	Interaction with RUNX1 and RUNX2.|Met-rich.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CCACAGCAATCATGGCTATAT	0.507000													11	142					0	0	1	0	0
SLC25A40	55972	broad.mit.edu	37	7	87487997	87487997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87487997G>A	ENST00000341119.5	-	3	392	c.46C>T	c.(46-48)Ctt>Ttt	p.L16F		NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40	16					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					ATTTGTTGAAGAGGTGTCACT	0.323000													18	49					0	0	1	0	0
BRCA1	672	broad.mit.edu	37	17	41246011	41246011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:41246011G>A	ENST00000309486.4	-	9	1676	c.649C>T	c.(649-651)Cat>Tat	p.H217Y	BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000493795.1_Missense_Mutation_p.H466Y|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000354071.3_Missense_Mutation_p.H513Y|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000346315.3_Missense_Mutation_p.H513Y|BRCA1_ENST00000357654.3_Missense_Mutation_p.H513Y|BRCA1_ENST00000471181.2_Missense_Mutation_p.H513Y	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	513					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCCTCAGGATGAAGGCCTGAT	0.388000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			13	29					0	0	1	0	0
FAS	355	broad.mit.edu	37	10	90762815	90762815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90762815C>T	ENST00000355740.2	+	2	280	c.60C>T	c.(58-60)tcC>tcT	p.S20S	FAS_ENST00000357339.2_Silent_p.S20S|FAS_ENST00000352159.4_Silent_p.S20S|FAS_ENST00000313771.5_3'UTR|FAS_ENST00000355279.2_Silent_p.S20S	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	20					activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		GATTATCGTCCAAAAGTGTTA	0.398000													24	66					0	0	1	0	0
PREB	10113	broad.mit.edu	37	2	27354630	27354630	+	Missense_Mutation	SNP	G	G	A	rs150589957	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27354630G>A	ENST00000260643.2	-	8	1322	c.1069C>T	c.(1069-1071)Cgt>Tgt	p.R357C	PREB_ENST00000406567.3_Missense_Mutation_p.R299C	NM_013388.4	NP_037520.1	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding	357					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGGACCACGACCCTTCTCA	0.567000													68	168					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952828	119952828	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119952828G>A	ENST00000307142.4	+	4	3094	c.2898G>A	c.(2896-2898)aaG>aaA	p.K966K	SYNPO2_ENST00000429713.2_Silent_p.K966K|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Silent_p.K966K	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	966						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ATGTCATGAAGCACCAACCGT	0.498000													19	58					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743479	81743479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81743479C>T	ENST00000555447.1	-	6	2588	c.2176G>A	c.(2176-2178)Gag>Aag	p.E726K	STON2_ENST00000267540.2_Missense_Mutation_p.E726K	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	726	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		ATCACATTCTCACAGGGAACC	0.552000													64	145					0	0	1	0	0
LINC00303	284573	broad.mit.edu	37	1	204006418	204006418	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204006418G>A	ENST00000367207.3	-	0	602																											GTGAACTTGGGGCACTGGAAA	0.502000													3	8					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170115597	170115597	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170115597C>T	ENST00000263816.3	-	17	2736	c.2451G>A	c.(2449-2451)acG>acA	p.T817T	LRP2_ENST00000443831.1_Silent_p.T680T	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	817					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGTGCGTCTCGTTTTATCAG	0.393000													64	138					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216062391	216062391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216062391C>T	ENST00000366943.2	-	41	7986	c.7600G>A	c.(7600-7602)Gga>Aga	p.G2534R	USH2A_ENST00000307340.3_Missense_Mutation_p.G2534R|RP5-1111A8.3_ENST00000414995.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2534	Fibronectin type-III 12.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACTACAGGTCCAGGTTCTGTA	0.413000										HNSCC(13;0.011)			17	53					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77347614	77347614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77347614G>A	ENST00000451710.3	-	36	6064	c.5827C>T	c.(5827-5829)Cct>Tct	p.P1943S	TRPM6_ENST00000361255.3_Missense_Mutation_p.P1934S|TRPM6_ENST00000360774.1_Missense_Mutation_p.P1939S|TRPM6_ENST00000376871.3_Missense_Mutation_p.P776S|TRPM6_ENST00000376872.3_Missense_Mutation_p.P894S|TRPM6_ENST00000449912.2_Missense_Mutation_p.P1934S			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1939	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TTGACTTCAGGTTTTATAACA	0.254000													8	36					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580591	140580591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580591C>T	ENST00000354757.3	+	1	1244	c.1244C>T	c.(1243-1245)gCc>gTc	p.A415V	PCDHB11_ENST00000536699.1_Missense_Mutation_p.A50V	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		415	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGAGCACAGCCGAGTACAAT	0.493000													31	127					0	0	1	0	0
IL15RA	3601	broad.mit.edu	37	10	6002493	6002493	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6002493C>T	ENST00000525219.2	-	4	606	c.312G>A	c.(310-312)gcG>gcA	p.A104A	IL15RA_ENST00000379971.1_Silent_p.A42A|IL15RA_ENST00000530685.1_Silent_p.A107A|IL15RA_ENST00000397250.2_Silent_p.A42A|IL15RA_ENST00000397248.2_Silent_p.A104A|IL15RA_ENST00000379977.3_Silent_p.A140A|IL15RA_ENST00000534292.1_5'UTR|IL15RA_ENST00000397251.3_Silent_p.A75A|IL15RA_ENST00000397255.3_Silent_p.A140A|IL15RA_ENST00000528354.1_Silent_p.A107A	NM_001243539.1	NP_001230468.1	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha	140					cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5						CTGTTGTGGCCGCTGTGTTGT	0.567000													19	38					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74536434	74536434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74536434G>A	ENST00000321288.5	+	4	739	c.739G>A	c.(739-741)Gct>Act	p.A247T	CCDC33_ENST00000398814.3_Missense_Mutation_p.A44T			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	247	C2.						protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CCTCCATGGGGCTACCAACCT	0.617000													19	101					0	0	1	0	0
C3orf56	285311	broad.mit.edu	37	3	126916055	126916055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126916055G>A	ENST00000398112.1	+	2	767	c.527G>A	c.(526-528)gGa>gAa	p.G176E		NM_001007534.2	NP_001007535.1			chromosome 3 open reading frame 56											breast(1)|endometrium(2)|kidney(1)|lung(5)	9				GBM - Glioblastoma multiforme(114;0.142)		CCATCCAGAGGAGCTCCCTAC	0.647000													24	47					0	0	1	0	0
CRYBB2	1415	broad.mit.edu	37	22	25627729	25627729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25627729C>T	ENST00000398215.2	+	6	779	c.608C>T	c.(607-609)cCc>cTc	p.P203L		NM_000496.2	NP_000487.1	P43320	CRBB2_HUMAN	crystallin, beta B2	203	C-terminal arm.				response to stimulus|visual perception		structural constituent of eye lens			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	10						GCCTTCCACCCCTCCAACTAG	0.622000													24	66					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	19018322	19018322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19018322C>T	ENST00000420770.2	+	5	744	c.661C>T	c.(661-663)Cgg>Tgg	p.R221W	PAX7_ENST00000375375.3_Missense_Mutation_p.R221W|PAX7_ENST00000400661.3_Missense_Mutation_p.R219W	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	221					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		GCGACGCAGTCGGACCACATT	0.637000			T	FOXO1A	alveolar rhabdomyosarcoma								7	18					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533142	169533142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169533142C>T	ENST00000449804.2	+	1	226	c.181C>T	c.(181-183)Ccc>Tcc	p.P61S	FOXI1_ENST00000306268.6_Missense_Mutation_p.P61S	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	61	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CACCCCCAACCCCTACCTCTG	0.677000									Pendred syndrome				7	22					0	0	1	0	0
POU3F4	5456	broad.mit.edu	37	X	82763827	82763827	+	Silent	SNP	G	G	T	rs56143048		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:82763827G>T	ENST00000373200.2	+	1	559	c.495G>T	c.(493-495)gtG>gtT	p.V165V	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	165					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						TGCACCCGGTGCTCCGAGAGC	0.647000													6	4					0.00116845	0.00116965	1	1	0
CABP2	51475	broad.mit.edu	37	11	67288529	67288529	+	Missense_Mutation	SNP	C	C	T	rs140767804	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67288529C>T	ENST00000294288.4	-	4	415	c.346G>A	c.(346-348)Gag>Aag	p.E116K	CABP2_ENST00000353903.5_Missense_Mutation_p.E59K	NM_016366.2	NP_057450.2	Q9NPB3	CABP2_HUMAN	calcium binding protein 2	116	EF-hand 2.				signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	9						AGCTCCATCTCGGTGGGCATG	0.627000													44	89					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511288	61511288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61511288G>A	ENST00000266070.4	-	16	6345	c.6020C>T	c.(6019-6021)tCg>tTg	p.S2007L	DIDO1_ENST00000395343.1_Missense_Mutation_p.S2007L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	2007	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GTGAAATCGCGAAGGGGTCTG	0.632000													14	191					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3000169	3000169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3000169G>A	ENST00000520002.1	-	42	6617	c.6062C>T	c.(6061-6063)tCt>tTt	p.S2021F	CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000542608.1_Missense_Mutation_p.S2020F|CSMD1_ENST00000400186.3_Missense_Mutation_p.S2021F|CSMD1_ENST00000602557.1_Missense_Mutation_p.S2021F|CSMD1_ENST00000537824.1_Missense_Mutation_p.S2020F|CSMD1_ENST00000602723.1_Missense_Mutation_p.S2021F|CSMD1_ENST00000539096.1_Missense_Mutation_p.S2020F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2021	CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGCTTCGGTAGAAAAATTCAG	0.398000													31	112					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72338444	72338444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:72338444C>T	ENST00000340595.3	+	11	1724	c.1528C>T	c.(1528-1530)Cgc>Tgc	p.R510C	SLC4A4_ENST00000425175.1_Missense_Mutation_p.R554C|SLC4A4_ENST00000512686.1_Missense_Mutation_p.R510C|SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000264485.5_Missense_Mutation_p.R554C|SLC4A4_ENST00000351898.6_Missense_Mutation_p.R554C	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	554						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TTTGGAGTTTCGCCTTTGGAT	0.408000													94	223					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97051876	97051876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:97051876G>A	ENST00000524981.3	+	4	670	c.670G>A	c.(670-672)Gtt>Att	p.V224I				Q6ZTY8	CL063_HUMAN		198										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GTTCAATACAGTTTCACAGTA	0.294000													17	52					0	0	1	0	0
IKBKE	9641	broad.mit.edu	37	1	206666435	206666435	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206666435C>T	ENST00000367120.3	+	19	2288	c.1915C>T	c.(1915-1917)Cag>Tag	p.Q639*	IKBKE_ENST00000462698.1_3'UTR|C1orf147_ENST00000367119.1_Intron|IKBKE_ENST00000537984.1_Nonsense_Mutation_p.Q554*	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	639					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					CCAGGGGGTCCAGGAGAGTCT	0.597000													3	10					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94929538	94929538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94929538G>A	ENST00000337425.5	-	5	1274	c.1200C>T	c.(1198-1200)ccC>ccT	p.P400P	SERPINA9_ENST00000448305.2_Silent_p.P302P|SERPINA9_ENST00000424550.2_Silent_p.P251P|RP11-349I1.2_ENST00000536735.1_RNA|SERPINA9_ENST00000380365.3_Silent_p.P382P|SERPINA9_ENST00000298845.7_Silent_p.P300P	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	382					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TGAAGTAAGAGGGGCCATCCT	0.498000													29	108					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44234858	44234858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44234858G>A	ENST00000330884.4	-	4	517	c.397C>T	c.(397-399)Cgc>Tgc	p.R133C	SULT4A1_ENST00000249130.5_Missense_Mutation_p.R133C|SULT4A1_ENST00000540422.1_Intron	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	133					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		TTGGGGTTGCGAGCCATATAG	0.572000													21	57					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119124924	119124924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119124924C>T	ENST00000328252.3	+	18	4770	c.4401C>T	c.(4399-4401)tcC>tcT	p.S1467S	PAPPA_ENST00000534838.1_Silent_p.S505S	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1467	Sushi 4.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GGAACGGCTCCTTCCATGTCT	0.532000													26	67					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32751281	32751281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32751281C>T	ENST00000333070.4	+	13	1684	c.1584C>T	c.(1582-1584)ttC>ttT	p.F528F	LCK_ENST00000373564.3_Silent_p.F505F|LCK_ENST00000336890.5_Silent_p.F498F	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	498					activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	AGGACTTCTTCACGGCCACAG	0.612000			T	TRB@	T-ALL								9	20					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103427784	103427784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103427784C>T	ENST00000358392.2	-	40	3415	c.3098G>A	c.(3097-3099)gGa>gAa	p.G1033E	COL11A1_ENST00000512756.1_Missense_Mutation_p.G905E|COL11A1_ENST00000353414.4_Missense_Mutation_p.G982E|COL11A1_ENST00000370096.3_Missense_Mutation_p.G1021E	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1021	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCCTGCTGGTCCATCTTTCCC	0.378000													18	103					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87772364	87772364	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87772364C>T	ENST00000398204.4	+	15	1567	c.1244C>T	c.(1243-1245)aCc>aTc	p.T415I	ADAM22_ENST00000398201.4_Missense_Mutation_p.T415I|ADAM22_ENST00000398209.3_Missense_Mutation_p.T415I|ADAM22_ENST00000315984.7_Missense_Mutation_p.T415I|ADAM22_ENST00000265727.7_Missense_Mutation_p.T415I	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	415	Peptidase M12B.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			AAAAAGTTCACCCAGTGTAAT	0.358000													32	127					0	0	1	0	0
LRRN4	164312	broad.mit.edu	37	20	6022607	6022607	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6022607C>T	ENST00000378858.4	-	5	1508	c.1284G>A	c.(1282-1284)ggG>ggA	p.G428G		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	428						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						AGGGGGCAGTCCCCTCCCGTG	0.657000													20	41					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32362678	32362678	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32362678C>T	ENST00000454136.3	-	6	1207	c.1203G>A	c.(1201-1203)acG>acA	p.T401T	BTNL2_ENST00000544175.1_Silent_p.T124T|BTNL2_ENST00000429232.2_3'UTR|BTNL2_ENST00000414363.1_Silent_p.T191T|BTNL2_ENST00000374993.1_Silent_p.T401T|BTNL2_ENST00000374995.3_Silent_p.T307T|BTNL2_ENST00000540315.1_Silent_p.T191T			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	401						integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						ATGATGGTATCGTCTTTCCTT	0.562000													25	191					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32774912	32774912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:32774912G>A	ENST00000265074.8	+	4	1501	c.1158G>A	c.(1156-1158)ggG>ggA	p.G386G	NPR3_ENST00000415685.2_Silent_p.G170G|NPR3_ENST00000415167.2_Silent_p.G386G|NPR3_ENST00000434067.2_Silent_p.G170G	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	386					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	AGGATGGAGGGAAAATTATAC	0.443000													62	114					0	0	1	0	0
MAN1C1	57134	broad.mit.edu	37	1	26012982	26012982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26012982G>A	ENST00000374332.4	+	2	922	c.592G>A	c.(592-594)Gaa>Aaa	p.E198K	MAN1C1_ENST00000263979.3_Missense_Mutation_p.E18K	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	198					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	p.E198K(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GGGGAAAAACGAACTCCGTCC	0.498000													59	141					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35224069	35224069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:35224069G>A	ENST00000360310.1	-	26	5005	c.4438C>T	c.(4438-4440)Cgt>Tgt	p.R1480C	BAZ1A_ENST00000382422.2_Missense_Mutation_p.R1480C|BAZ1A_ENST00000358716.4_Missense_Mutation_p.R1448C	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1480	Bromo.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		ACTTTTTCACGAATTATATTT	0.284000													19	39					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90503636	90503636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90503636C>T	ENST00000325643.5	+	4	4300	c.4234C>T	c.(4234-4236)Cca>Tca	p.P1412S		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCCTGTGTCCCCAGCTGGTCC	0.627000													18	38					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89266222	89266222	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89266222G>A	ENST00000464162.1	-	0	64																											AGAGCAGCAGGAGCCCCAGGA	0.557000													54	179					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22783059	22783059	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22783059G>A	ENST00000600260.1	+	0	566					NR_033899.1																						GGAGGAGCTGGAGAGTCTGGC	0.632000													3	8					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109730818	109730818	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109730818G>A	ENST00000369939.3	+	9	1244	c.1061G>A	c.(1060-1062)tGg>tAg	p.W354*	KIAA1324_ENST00000529753.1_Nonsense_Mutation_p.W267*|KIAA1324_ENST00000369938.1_3'UTR	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	354					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		ATGTACAAATGGGCCAAGCCG	0.532000													33	90					0	0	1	0	0
TMEM151A	256472	broad.mit.edu	37	11	66062685	66062685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66062685C>T	ENST00000327259.4	+	2	1112	c.968C>T	c.(967-969)tCg>tTg	p.S323L		NM_153266.3	NP_694998.1	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	323						integral to membrane				central_nervous_system(1)|kidney(4)|lung(6)	11						GGCGCCAGCTcgcccccgccg	0.716000													5	11					0	0	1	0	0
CBR3-AS1	100506428	broad.mit.edu	37	21	37504920	37504920	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37504920G>A	ENST00000413862.1	-	0	706				CBR3-AS1_ENST00000453159.1_RNA	NR_038892.1																						AAGGCCGCCCGGGAGCTGCTG	0.567000													4	12					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26115882	26115882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26115882C>T	ENST00000313735.6	-	4	504	c.271G>A	c.(271-273)Ggc>Agc	p.G91S		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	91					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	ATCCCGCTGCCCCAGTTTTTG	0.527000													61	74					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2786979	2786979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2786979G>A	ENST00000399655.1	+	41	5302	c.5037G>A	c.(5035-5037)ctG>ctA	p.L1679L	CACNA1C_ENST00000347598.4_Silent_p.L1727L|CACNA1C_ENST00000399591.1_Silent_p.L1687L|CACNA1C_ENST00000344100.3_Silent_p.L1720L|CACNA1C_ENST00000399597.1_Silent_p.L1679L|CACNA1C_ENST00000335762.5_Silent_p.L1704L|CACNA1C_ENST00000399595.1_Silent_p.L1687L|CACNA1C_ENST00000399603.1_Silent_p.L1679L|CACNA1C_ENST00000399617.1_Silent_p.L1679L|CACNA1C_ENST00000399606.1_Silent_p.L1699L|CACNA1C_ENST00000399621.1_Silent_p.L1698L|CACNA1C_ENST00000399601.1_Silent_p.L1679L|CACNA1C_ENST00000399638.1_Silent_p.L1707L|CACNA1C_ENST00000399649.1_Silent_p.L1685L|CACNA1C_ENST00000399644.1_Silent_p.L1679L|CACNA1C_ENST00000399629.1_Silent_p.L1696L|CACNA1C_ENST00000327702.7_Silent_p.L1679L|CACNA1C_ENST00000399634.1_Silent_p.L1679L|CACNA1C_ENST00000399637.1_Silent_p.L1698L|CACNA1C_ENST00000406454.3_Silent_p.L1679L|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000402845.3_Silent_p.L1698L|CACNA1C_ENST00000399641.1_Silent_p.L1679L	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1727					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGGAGGAGCTGGACAAGGCCA	0.577000													16	45					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179567368	179567368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179567368C>T	ENST00000589042.1	-	107	30470	c.30246G>A	c.(30244-30246)aaG>aaA	p.K10082K	TTN_ENST00000342992.6_Silent_p.K8838K|TTN_ENST00000591111.1_Silent_p.K9765K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9765	Glu-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGTATGCGCTTTGTAAACT	0.393000													16	51					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170729	207170729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207170729G>A	ENST00000374423.3	+	5	1863	c.1477G>A	c.(1477-1479)Gaa>Aaa	p.E493K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	493							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TAGTAGTTCTGAAACGAATTT	0.393000													12	51					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172737294	172737294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172737294C>T	ENST00000351008.3	-	4	1013	c.830G>A	c.(829-831)aGg>aAg	p.R277K		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	277					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTCTGAATACCTCTCCAGACA	0.348000													37	163					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220333881	220333881	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220333881G>A	ENST00000312358.7	+	13	3627	c.3495G>A	c.(3493-3495)tcG>tcA	p.S1165S	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1165					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTTGCAGCTCGAAGCTGGAGA	0.667000													8	15					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8181439	8181439	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:8181439G>A	ENST00000402384.3	-	10	1177	c.911C>T	c.(910-912)tCa>tTa	p.S304L	ICA1_ENST00000422063.2_Missense_Mutation_p.S333L|ICA1_ENST00000396675.3_Missense_Mutation_p.S304L|ICA1_ENST00000265577.7_Missense_Mutation_p.S303L|ICA1_ENST00000401396.1_Missense_Mutation_p.S292L|ICA1_ENST00000406470.2_Missense_Mutation_p.S304L			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	304					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TTCCTCTAATGAAATTAATCT	0.279000													3	22					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50209536	50209536	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50209536G>A	ENST00000392518.4	+	12	1581	c.1209G>A	c.(1207-1209)gaG>gaA	p.E403E	CPT1C_ENST00000405931.2_Silent_p.E392E|CPT1C_ENST00000323446.5_Silent_p.E403E|CPT1C_ENST00000354199.5_Silent_p.E403E|CPT1C_ENST00000598293.1_Silent_p.E403E	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	403					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		AGGCAGCGGAGGCCCTGGAGG	0.701000													5	23					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228467761	228467761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228467761C>T	ENST00000570156.2	+	33	8997	c.8923C>T	c.(8923-8925)Cac>Tac	p.H2975Y	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.H2546Y|OBSCN_ENST00000284548.11_Missense_Mutation_p.H2546Y|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000359599.6_Missense_Mutation_p.H1393Y	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1976	Ig-like 29.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGCAGTGCCCACAGCAGCAC	0.617000													5	13					0	0	1	0	0
ZBED6CL	113763	broad.mit.edu	37	7	150027920	150027920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150027920G>A	ENST00000343855.4	+	1	983	c.427G>A	c.(427-429)Gag>Aag	p.E143K	LRRC61_ENST00000493307.1_Intron|LRRC61_ENST00000359623.4_Intron|LRRC61_ENST00000323078.7_Intron	NM_138434.2	NP_612443.1			ZBED6 C-terminal like																		CTCCGGGGTGGAGGGGAGAAG	0.632000													12	34					0	0	1	0	0
WDR89	112840	broad.mit.edu	37	14	64066611	64066611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:64066611G>A	ENST00000394942.2	-	2	138	c.50C>T	c.(49-51)tCc>tTc	p.S17F	WDR89_ENST00000267522.3_Missense_Mutation_p.S17F	NM_001008726.2|NM_001258272.1|NM_080666.3	NP_001008726.1|NP_001245201.1|NP_542397.1	Q96FK6	WDR89_HUMAN	WD repeat domain 89	17										endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.00543)|all cancers(60;0.0181)|BRCA - Breast invasive adenocarcinoma(234;0.101)		GGTTCCTAAGGAACATTTAAC	0.363000													8	117					0	0	1	0	0
SVOP	55530	broad.mit.edu	37	12	109309618	109309618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109309618G>A	ENST00000299134.5	-	13	1184	c.1185C>T	c.(1183-1185)gcC>gcT	p.A395A		NM_018711.2	NP_061181.1	Q8N4V2	SVOP_HUMAN	SV2 related protein homolog (rat)	0						cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity			breast(2)|lung(4)	6						CAGGTGCCCAGGCCGAGGGCC	0.622000													3	20					0	0	1	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19362866	19362866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:19362866C>T	ENST00000454498.2	-	4	1493	c.480G>A	c.(478-480)gaG>gaA	p.E160E	CSGALNACT1_ENST00000544602.1_Silent_p.E160E|CSGALNACT1_ENST00000522854.1_Silent_p.E160E|CSGALNACT1_ENST00000332246.6_Silent_p.E160E|CSGALNACT1_ENST00000311540.4_Silent_p.E160E	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	160					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		TAAGGCCAGTCTCCAGCTGGT	0.557000													29	37					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238045826	238045826	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:238045826G>A	ENST00000366570.4	-	12	1677	c.1519C>T	c.(1519-1521)Ctg>Ttg	p.L507L	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	507					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GCCACCCACAGAACTTTCGAG	0.463000													34	101					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148601507	148601507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:148601507G>A	ENST00000296046.3	+	9	938	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	296					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CCACCTGAATGAAATCAAGGT	0.443000													34	77					0	0	1	0	0
MIR124-2HG	100130155	broad.mit.edu	37	8	65291793	65291793	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:65291793G>A	ENST00000521441.1	+	0	655				MIR124-2_ENST00000385081.1_RNA																							TGCCAAGAGCGGAGCCTACGG	0.478000													11	23					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140183064	140183064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140183064G>A	ENST00000522353.2	+	1	2282	c.2282G>A	c.(2281-2283)gGa>gAa	p.G761E	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.G761E|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGTGCTCTGGAGAGGGGTTG	0.607000													33	108					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84700164	84700164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84700164C>T	ENST00000286744.5	+	28	4958	c.4734C>T	c.(4732-4734)tcC>tcT	p.S1578S	ADAMTSL3_ENST00000567476.1_Silent_p.S1578S	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1578						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCTCTGACTCCAACTGTGATG	0.512000													54	220					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610124	47610124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47610124C>T	ENST00000371891.3	+	7	917	c.886C>T	c.(886-888)Ctc>Ttc	p.L296F	CYP4A22_ENST00000371890.3_Missense_Mutation_p.P244L|CYP4A22_ENST00000294337.3_Missense_Mutation_p.L296F|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000485117.1_3'UTR	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	296						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GGACATCCTCCTCTTGGCCAA	0.507000													35	103					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108690226	108690226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108690226G>A	ENST00000232603.5	-	25	2583	c.2501C>T	c.(2500-2502)cCt>cTt	p.P834L	MORC1_ENST00000483760.1_Missense_Mutation_p.P813L	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	834					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						CTGATGCTCAGGAAAAAAATA	0.408000													24	69					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101816796	101816796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101816796C>T	ENST00000370418.3	-	6	1236	c.985G>A	c.(985-987)Gaa>Aaa	p.E329K		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	329	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		ATTAGGGCTTCCCGATTACCC	0.463000													82	252					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55955574	55955574	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55955574C>T	ENST00000263923.4	-	25	3666	c.3371G>A	c.(3370-3372)aGa>aAa	p.R1124K	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1124	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GGCCCTCATTCTAGTTCCTTC	0.398000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			21	44					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111979231	111979231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111979231G>A	ENST00000374566.3	-	16	2121	c.1604C>T	c.(1603-1605)tCc>tTc	p.S535F		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	535						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGAGTTTGGGGACCTCAGAGG	0.582000													44	165					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151784500	151784500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:151784500C>T	ENST00000255262.3	-	1	340	c.175G>A	c.(175-177)Ggg>Agg	p.G59R	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	59					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			CCAATGACCCCCACCACAAAA	0.577000													22	66					0	0	1	0	0
C6orf222	389384	broad.mit.edu	37	6	36287141	36287141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36287141C>T	ENST00000437635.2	-	11	2092	c.1915G>A	c.(1915-1917)Gac>Aac	p.D639N		NM_001010903.4	NP_001010903.3	P0C671	CF222_HUMAN	chromosome 6 open reading frame 222	639										breast(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(4)|urinary_tract(4)	26						ACCGGCTGGTCCTCCCTGTAT	0.542000													32	99					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606647	55606647	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55606647G>A	ENST00000378396.1	+	1	420	c.420G>A	c.(418-420)caG>caA	p.Q140Q		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				CCATCTCCCAGAAACTCTGTG	0.463000													39	80					0	0	1	0	0
LCN6	158062	broad.mit.edu	37	9	139641983	139641983	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139641983G>A	ENST00000435202.1	-	2	92	c.93C>T	c.(91-93)gcC>gcT	p.A31A	LCN6_ENST00000341206.4_Silent_p.A41A			P62502	LCN6_HUMAN	lipocalin 6	41					single fertilization	extracellular region	binding			lung(3)|upper_aerodigestive_tract(1)	4	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.32e-06)|Epithelial(140;7.83e-05)		TTTCCCGGGAGGCCACCGCAA	0.637000													16	48					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115221019	115221019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115221019C>T	ENST00000369538.3	-	7	1161	c.1114G>A	c.(1114-1116)Gaa>Aaa	p.E372K	AMPD1_ENST00000353928.6_Missense_Mutation_p.E343K|AMPD1_ENST00000520113.2_Missense_Mutation_p.E376K	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	343					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	GCAAAAAGTTCCTTTAGGGTC	0.378000													50	118					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117403124	117403124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117403124G>A	ENST00000321322.6	-	4	806	c.805C>T	c.(805-807)Cgg>Tgg	p.R269W	DSCAML1_ENST00000527706.1_Intron	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	209	Ig-like C2-type 3.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TTGCTCTGCCGGGTCTCCCCG	0.617000													9	75					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61559014	61559014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61559014G>A	ENST00000290866.4	+	7	1057	c.1033G>A	c.(1033-1035)Ggg>Agg	p.G345R	ACE_ENST00000584529.1_3'UTR|ACE_ENST00000428043.1_Missense_Mutation_p.G345R|ACE_ENST00000538928.1_Missense_Mutation_p.G345R	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	345	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GTTCTGGGAAGGGTCGATGCT	0.622000													34	50					0	0	1	0	0
OR2T5	401993	broad.mit.edu	37	1	248651978	248651978	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248651978T>C	ENST00000366473.2	+	1	94	c.89T>C	c.(88-90)cTa>cCa	p.L30P		NM_001004697.1	NP_001004697.1	Q6IEZ7	OR2T5_HUMAN	olfactory receptor, family 2, subfamily T, member 5	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(2)|pancreas(1)|skin(2)	9	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CATCCAGCTCTACTTAGTGTG	0.502000													10	183					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1963716	1963716	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1963716C>T	ENST00000217305.2	-	3	240	c.15G>A	c.(13-15)ggG>ggA	p.G5G	RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Silent_p.G5G|PDYN_ENST00000539905.1_Silent_p.G5G	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	5					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CCAGGACCAGCCCCTGCCAGG	0.567000													8	42					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15654992	15654992	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15654992G>A	ENST00000269703.2	+	10	1237	c.1038G>A	c.(1036-1038)tgG>tgA	p.W346*	CYP4F22_ENST00000601005.2_Nonsense_Mutation_p.W346*	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	346						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						GGATCTCTTGGATGCTGTTCA	0.507000													39	105					0	0	1	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179044567	179044567	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179044567G>A	ENST00000356731.5	-	8	2540	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	HNRNPH1_ENST00000510411.1_Silent_p.F335F|HNRNPH1_ENST00000442819.2_Silent_p.F335F|HNRNPH1_ENST00000393432.4_Silent_p.F335F|HNRNPH1_ENST00000329433.6_Silent_p.F335F|HNRNPH1_ENST00000511300.2_Silent_p.F65F			P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1 (H)	335	2 X 16 AA Gly-rich approximate repeats.|RRM 3.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|skin(1)	14						CATGAGTTGCGAACTCGACAT	0.438000													66	124					0	0	1	0	0
FAM110C	642273	broad.mit.edu	37	2	45946	45946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:45946C>T	ENST00000327669.4	-	1	439	c.440G>A	c.(439-441)gGg>gAg	p.G147E		NM_001077710.2	NP_001071178.2	Q1W6H9	F110C_HUMAN	family with sequence similarity 110, member C	147						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		CTCCGGGTTCCCGGCCTTGCC	0.756000													7	9					0	0	1	0	0
CT45A5	441521	broad.mit.edu	37	X	134947909	134947909	+	Missense_Mutation	SNP	C	C	T	rs143395460	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:134947909C>T	ENST00000370724.3	-	3	660	c.416G>A	c.(415-417)cGa>cAa	p.R139Q	CT45A5_ENST00000491480.1_Missense_Mutation_p.R139Q|CT45A4_ENST00000420087.2_Intron	NM_001007551.3|NM_001172288.1	NP_001007552.1|NP_001165759.1	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	139								p.R139Q(2)		endometrium(1)|large_intestine(2)|lung(6)	9						CTACTTACTTCGTCCAAGGCA	0.388000													39	26					0	0	1	0	0
SSTR1	6751	broad.mit.edu	37	14	38678933	38678933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:38678933C>T	ENST00000267377.2	+	3	956	c.339C>T	c.(337-339)ttC>ttT	p.F113F		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	113					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GCGTGCCCTTCCTAGTCACCT	0.572000													50	202					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137655578	137655578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137655578G>A	ENST00000371817.3	+	20	2443	c.2029G>A	c.(2029-2031)Gag>Aag	p.E677K		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	677	Triple-helical region.			E -> K (in Ref. 1; BAA14323).|E -> Q (in Ref. 4; AA sequence).	axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GCTGCCTGGGGAGCCCGTAAG	0.592000													10	82					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7151403	7151403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:7151403G>A	ENST00000303635.7	+	4	481	c.274G>A	c.(274-276)Gaa>Aaa	p.E92K	CAMTA1_ENST00000439411.2_Missense_Mutation_p.E92K	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GAAACACGAAGAATGGCTAAC	0.353000			T	WWTR1	epitheliod hemangioendothelioma								27	57					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53619662	53619662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53619662C>T	ENST00000594011.1	-	4	298	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	ZNF415_ENST00000243643.4_Missense_Mutation_p.E14K|ZNF415_ENST00000597503.1_Missense_Mutation_p.E14K|ZNF415_ENST00000601215.1_Intron|ZNF415_ENST00000601493.1_Intron|ZNF415_ENST00000440291.1_5'UTR|ZNF415_ENST00000599261.1_Missense_Mutation_p.E14K|ZNF415_ENST00000455735.2_5'UTR|ZNF415_ENST00000600574.1_Missense_Mutation_p.E14K|ZNF415_ENST00000597748.1_Missense_Mutation_p.E14K|ZNF415_ENST00000596683.1_5'UTR|ZNF415_ENST00000500065.4_Missense_Mutation_p.E14K|ZNF415_ENST00000595193.1_Missense_Mutation_p.E14K|ZNF415_ENST00000421033.1_5'UTR|ZNF415_ENST00000448501.1_5'UTR|ZNF415_ENST00000595813.1_Missense_Mutation_p.E14K			Q09FC8	ZN415_HUMAN	zinc finger protein 415	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		TGAGAGAATTCGATGGCCACG	0.423000													31	141					0	0	1	0	0
WFDC10B	280664	broad.mit.edu	37	20	44333610	44333610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44333610C>T	ENST00000335769.2	-	1	48	c.21G>A	c.(19-21)agG>agA	p.R7R	WFDC10B_ENST00000330523.5_5'UTR|WFDC13_ENST00000305479.2_Intron	NM_172131.2	NP_742143.1	Q8IUB3	WF10B_HUMAN	WAP four-disulfide core domain 10B	0						extracellular region	peptidase inhibitor activity			lung(2)|ovary(1)|stomach(1)	4		Myeloproliferative disorder(115;0.0122)				TTTTGCTTGCCCTCCTTTCAC	0.483000													40	157					0	0	1	0	0
TRAV4	28689	broad.mit.edu	37	14	22205179	22205179	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22205179C>T	ENST00000390426.2	+	0	310																											CCCTGTTTATCCCTGCCGACA	0.498000													17	19					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33463397	33463397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33463397G>A	ENST00000455041.2	-	23	2940	c.2881C>T	c.(2881-2883)Cgc>Tgc	p.R961C	NOL6_ENST00000379471.2_Intron|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	1013					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGAGACAGGCGAATCAGCACG	0.652000													9	33					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38805726	38805726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38805726C>T	ENST00000359357.3	+	31	3977	c.3723C>T	c.(3721-3723)ttC>ttT	p.F1241F	DNAH8_ENST00000441566.1_Silent_p.F1241F|DNAH8_ENST00000449981.2_Silent_p.F1458F					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGGCCAGTTTCGATGATCTGT	0.323000													20	50					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169251	113169251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113169251C>T	ENST00000401783.2	-	38	8965	c.8629G>A	c.(8629-8631)Gga>Aga	p.G2877R	SVEP1_ENST00000374469.1_Missense_Mutation_p.G2854R|SVEP1_ENST00000297826.5_Missense_Mutation_p.G803R	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2877	Sushi 24.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTCCAACTTCCATTGGCAAGA	0.537000													16	46					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29039818	29039818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29039818G>A	ENST00000257189.4	+	6	611	c.528G>A	c.(526-528)gtG>gtA	p.V176V		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	176	Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACTCACTGGTGATGATACTAA	0.353000													17	50					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	145972622	145972622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145972622G>A	ENST00000394413.3	-	8	1534	c.964C>T	c.(964-966)Cat>Tat	p.H322Y	CTB-99A3.1_ENST00000512730.1_RNA|PPP2R2B_ENST00000394409.3_Missense_Mutation_p.H380Y|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.H311Y|PPP2R2B_ENST00000394414.1_Missense_Mutation_p.H388Y|PPP2R2B_ENST00000453001.1_Missense_Mutation_p.H322Y|PPP2R2B_ENST00000356826.3_Missense_Mutation_p.H322Y|PPP2R2B_ENST00000394411.4_Missense_Mutation_p.H322Y|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.H325Y|PPP2R2B_ENST00000508545.2_Missense_Mutation_p.H311Y|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.H328Y			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	322					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGTAGTCATGAACCTGGAGA	0.393000													54	117					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448661	155448661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155448661G>A	ENST00000368346.3	-	3	4639	c.4000C>T	c.(4000-4002)Ccc>Tcc	p.P1334S	ASH1L_ENST00000392403.3_Missense_Mutation_p.P1334S			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1334					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GGGTCTAAGGGGAAAGAAGGA	0.408000													27	96					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54872761	54872761	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54872761C>T	ENST00000391743.3	-	2	352	c.72G>A	c.(70-72)ggG>ggA	p.G24G	LAIR1_ENST00000391742.2_Silent_p.G42G|LAIR1_ENST00000474878.1_Silent_p.G41G|LAIR1_ENST00000434277.2_Silent_p.G41G|LAIR1_ENST00000313038.6_Silent_p.G35G|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000348231.4_Silent_p.G42G			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	42						integral to membrane|plasma membrane	protein binding|receptor activity	p.G42G(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		TCACATGGCTCCCCAGGGGGA	0.572000													60	150					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	825227	825227	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:825227C>T	ENST00000297440.6	+	13	2525	c.2505C>T	c.(2503-2505)caC>caT	p.H835H	HEATR2_ENST00000313147.5_Intron|HEATR2_ENST00000403952.3_Silent_p.H260H	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	835							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		TCCACAAGCACCGCTCGGCCA	0.602000													32	61					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159548022	159548022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:159548022C>T	ENST00000307765.5	+	10	1057	c.806C>T	c.(805-807)tCc>tTc	p.S269F	RXFP1_ENST00000343542.5_Missense_Mutation_p.S269F|RXFP1_ENST00000470033.1_Missense_Mutation_p.S236F|RXFP1_ENST00000460056.2_Missense_Mutation_p.S188F|RXFP1_ENST00000448688.2_Intron	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	269						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding	p.S269F(2)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		ACTTTTATTTCCTGCAGTAAT	0.269000													10	38					0	0	1	0	0
GREM1	26585	broad.mit.edu	37	15	33023078	33023078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33023078G>A	ENST00000300177.4	+	2	376	c.187G>A	c.(187-189)Ggg>Agg	p.G63R	GREM1_ENST00000322805.4_Intron|GREM1_ENST00000560830.1_Intron|GREM1_ENST00000560677.1_Intron	NM_001191322.1|NM_001191323.1|NM_013372.6	NP_001178251.1|NP_001178252.1|NP_037504.1	O60565	GREM1_HUMAN	gremlin 1, DAN family BMP antagonist	63					negative regulation of BMP signaling pathway|nervous system development|regulation of epithelial to mesenchymal transition	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)	10		all_lung(180;1.49e-09)		all cancers(64;2.97e-18)|Epithelial(43;3.15e-12)|GBM - Glioblastoma multiforme(186;2.32e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0107)		GCGGGGCCAAGGGCGGGGCAC	0.662000													11	49					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89827573	89827573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89827573C>T	ENST00000264344.5	-	6	1007	c.800G>A	c.(799-801)aGa>aAa	p.R267K	FAM13A_ENST00000502459.1_5'UTR|FAM13A_ENST00000511976.1_Missense_Mutation_p.R58K	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	267					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TTCTAAGCCTCTTGTTAAAAG	0.368000													167	417					0	0	1	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67174477	67174477	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67174477C>T	ENST00000312390.5	+	8	857	c.828C>T	c.(826-828)ttC>ttT	p.F276F	TBC1D10C_ENST00000542590.1_Silent_p.F276F|TBC1D10C_ENST00000526387.1_Intron	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	276	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GGGATGCCTTCCTCAGTGAGG	0.662000													48	120					0	0	1	0	0
MAPK1	5594	broad.mit.edu	37	22	22123583	22123583	+	Silent	SNP	G	G	A	rs62235129		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22123583G>A	ENST00000215832.6	-	8	1181	c.993C>T	c.(991-993)ttC>ttT	p.F331F	MAPK1_ENST00000491588.1_5'UTR|MAPK1_ENST00000398822.3_Silent_p.F331F|MAPK1_ENST00000544786.1_Silent_p.F287F	NM_002745.4	NP_002736.3	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	331					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	ATTCCATGTCGAACTTGAATG	0.368000													32	60					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31816128	31816128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:31816128G>A	ENST00000446923.2	+	9	3654	c.3263G>A	c.(3262-3264)aGc>aAc	p.S1088N	ZEB1_ENST00000560721.2_Missense_Mutation_p.S1084N|ZEB1_ENST00000361642.5_Missense_Mutation_p.S1105N|ZEB1_ENST00000542815.3_Missense_Mutation_p.S1037N|ZEB1_ENST00000320985.10_Missense_Mutation_p.S1104N	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1104	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CAAGCAAGCAGCTTAGGACAA	0.403000													9	20					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50367257	50367257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50367257G>A	ENST00000331340.3	+	3	219	c.64G>A	c.(64-66)Gat>Aat	p.D22N	IKZF1_ENST00000346667.4_Missense_Mutation_p.D22N|IKZF1_ENST00000357364.4_Missense_Mutation_p.D22N|IKZF1_ENST00000439701.1_Missense_Mutation_p.D22N|IKZF1_ENST00000359197.5_Missense_Mutation_p.D22N|IKZF1_ENST00000438033.1_Missense_Mutation_p.D22N|IKZF1_ENST00000343574.5_Missense_Mutation_p.D22N|IKZF1_ENST00000492782.1_3'UTR|IKZF1_ENST00000440768.2_Missense_Mutation_p.D22N|IKZF1_ENST00000349824.4_Missense_Mutation_p.D22N|IKZF1_ENST00000413698.1_Missense_Mutation_p.D22N	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	22					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(33)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CCCTGTAAGCGATACTCCAGA	0.587000			"""D,T"""	BCL6	"""ALL, DLBCL"""								7	18					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803315	54803315	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54803315G>A	ENST00000391745.1	-	8	729	c.413C>T	c.(412-414)gCc>gTc	p.A138V	LILRA3_ENST00000391744.3_Missense_Mutation_p.A121V|LILRA3_ENST00000251390.3_Missense_Mutation_p.A121V					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTTGCTGTAGGCTCCTAGGAG	0.602000													24	158					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46718188	46718188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46718188G>A	ENST00000318962.4	-	18	2055	c.1972C>T	c.(1972-1974)Ctg>Ttg	p.L658L	ALS2CL_ENST00000415953.1_Silent_p.L658L|ALS2CL_ENST00000383742.3_Silent_p.L5L	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	658					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AGCTCCTCCAGGATGTCTTCC	0.652000													26	51					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138697051	138697051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:138697051G>A	ENST00000520602.1	-	13	1817	c.1532C>T	c.(1531-1533)tCa>tTa	p.S511L	MCF2_ENST00000370573.4_Missense_Mutation_p.S451L|MCF2_ENST00000370578.4_Missense_Mutation_p.S596L|MCF2_ENST00000536274.1_Missense_Mutation_p.S412L|MCF2_ENST00000483690.1_5'UTR|MCF2_ENST00000338585.6_Missense_Mutation_p.S451L|MCF2_ENST00000414978.1_Missense_Mutation_p.S511L|MCF2_ENST00000370576.4_Missense_Mutation_p.S451L|MCF2_ENST00000519895.1_Missense_Mutation_p.S511L			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	451	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TTGTTTAGATGAAAAAAATGG	0.368000													54	58					0	0	1	0	0
NUAK1	9891	broad.mit.edu	37	12	106461006	106461006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:106461006C>T	ENST00000261402.2	-	7	2939	c.1560G>A	c.(1558-1560)cgG>cgA	p.R520R		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	520							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TGCCCTTCCTCCGGCAGGAGA	0.612000													19	59					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47401263	47401263	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47401263G>C	ENST00000310638.4	-	5	598	c.567C>G	c.(565-567)gtC>gtG	p.V189V	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Silent_p.V189V|CYP4A11_ENST00000371905.1_Silent_p.V189V|CYP4A11_ENST00000457840.2_Silent_p.V85V	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	189					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	TCATCAAGGAGACGTGCTGAA	0.567000													14	67					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5182205	5182205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:5182205C>T	ENST00000274181.7	+	4	688	c.550C>T	c.(550-552)Cct>Tct	p.P184S	ADAMTS16_ENST00000511368.1_Missense_Mutation_p.P184S	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	184					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AAGGCCACTTCCTTCACACCT	0.488000													43	97					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23896011	23896011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23896011G>A	ENST00000355349.3	-	18	2181	c.2019C>T	c.(2017-2019)atC>atT	p.I673I		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	673	Actin-binding.|Myosin head-like.			CII -> LYH (in Ref. 2; CAA37068).	adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATTAGGGATGATACAACGTA	0.493000													19	52					0	0	1	0	0
CPVL	54504	broad.mit.edu	37	7	29160613	29160613	+	Missense_Mutation	SNP	C	C	T	rs148332481	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:29160613C>T	ENST00000409850.1	-	6	711	c.65G>A	c.(64-66)gGg>gAg	p.G22E	CPVL_ENST00000488891.2_5'UTR|CPVL_ENST00000265394.5_Missense_Mutation_p.G22E|CPVL_ENST00000396276.3_Missense_Mutation_p.G22E			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	22					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						GCGAAACAGCCCATCACAGGG	0.488000													34	67					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61941141	61941141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61941141C>T	ENST00000280772.1	-	18	2321	c.2130G>A	c.(2128-2130)gtG>gtA	p.V710V	ANK3_ENST00000503366.1_Silent_p.V693V|ANK3_ENST00000373827.2_Silent_p.V704V	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	710					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGCCACATTCACTCGATCTT	0.517000													45	103					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62579893	62579893	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62579893C>T	ENST00000371158.2	+	35	4744	c.4630C>T	c.(4630-4632)Ctg>Ttg	p.L1544L	INADL_ENST00000545929.1_Silent_p.L189L|INADL_ENST00000316485.6_Silent_p.L1574L|INADL_ENST00000543708.1_Silent_p.L358L	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1544	PDZ 9.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TGGCCGGGGCCTGGGCCTGAG	0.537000													14	46					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386606	56386606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56386606C>T	ENST00000355701.3	-	22	4897	c.4027G>A	c.(4027-4029)Gag>Aag	p.E1343K	BZRAP1_ENST00000268893.6_Missense_Mutation_p.E1283K|BZRAP1_ENST00000343736.4_Missense_Mutation_p.E1343K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1343	Poly-Glu.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tcctcctcctcgtcctcctct	0.607000													18	39					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140724405	140724405	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140724405C>T	ENST00000253812.6	+	1	805	c.805C>T	c.(805-807)Cct>Tct	p.P269S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCACTGACCCTGACGAGGG	0.473000													9	44					0	0	1	0	0
ST7L	54879	broad.mit.edu	37	1	113084621	113084621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113084621G>A	ENST00000358039.4	-	14	1885	c.1581C>T	c.(1579-1581)gcC>gcT	p.A527A	ST7L_ENST00000544629.1_Silent_p.A462A|ST7L_ENST00000538187.1_Silent_p.A471A|ST7L_ENST00000490067.1_Silent_p.A510A|ST7L_ENST00000463235.1_5'UTR|ST7L_ENST00000369666.1_Silent_p.A510A|ST7L_ENST00000369669.1_Silent_p.A344A|ST7L_ENST00000360743.4_Silent_p.A496A|ST7L_ENST00000343210.7_Silent_p.A527A|ST7L_ENST00000369668.2_Silent_p.A527A	NM_017744.4|NM_138727.3	NP_060214.2|NP_620055.1	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7 like	527					negative regulation of cell growth	integral to membrane	binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(1)|prostate(2)|stomach(1)|urinary_tract(3)	15	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGTGAGAATGGCTATCATTG	0.378000													22	69					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22729303	22729303	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:22729303C>T	ENST00000511446.1	+	0	61				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TTCACATTTTCAAATGAAGAT	0.423000													75	199					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170139474	170139474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170139474C>T	ENST00000263816.3	-	10	1365	c.1080G>A	c.(1078-1080)caG>caA	p.Q360Q	LRP2_ENST00000443831.1_Silent_p.Q360Q	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	360	EGF-like 2.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTTCACACTTCTGGTCACAAA	0.433000													64	152					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5042699	5042699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:5042699C>T	ENST00000574788.1	+	22	3458	c.1228C>T	c.(1228-1230)Cgt>Tgt	p.R410C	USP6_ENST00000332776.4_Missense_Mutation_p.R410C|USP6_ENST00000304328.5_Missense_Mutation_p.R93C|USP6_ENST00000250066.6_Missense_Mutation_p.R410C			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	410					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						ATGGGCATCTCGTTTTTCCAC	0.657000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								17	28					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93624558	93624558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:93624558C>T	ENST00000375754.4	+	4	797	c.649C>T	c.(649-651)Cgc>Tgc	p.R217C	SYK_ENST00000375746.1_Missense_Mutation_p.R217C|SYK_ENST00000375751.4_Missense_Mutation_p.R217C|SYK_ENST00000375747.1_Missense_Mutation_p.R217C	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	217	SH2 2.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						GCTGCACTATCGCATCGACAA	0.577000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								6	28					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878113	24878113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24878113C>T	ENST00000382554.3	+	4	1431	c.1113C>T	c.(1111-1113)atC>atT	p.I371I		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	371					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TCTGGAGGATCAATGAGCTGC	0.607000													12	12					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101778392	101778392	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101778392G>A	ENST00000375001.3	+	11	2061	c.1638G>A	c.(1636-1638)tgG>tgA	p.W546*		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	546	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CTGAAAGATGGATCACTCCAG	0.597000													4	29					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59282609	59282609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59282609C>T	ENST00000329328.3	+	1	224	c.224C>T	c.(223-225)tCc>tTc	p.S75F		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						TGCTTTTCCTCCATCACAGCT	0.458000													17	187					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49662672	49662672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49662672C>T	ENST00000296452.4	+	2	603	c.489C>T	c.(487-489)ccC>ccT	p.P163P		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	163					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGATCGCCCCCCTTCCCAGCA	0.612000													32	88					0	0	1	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516385	138516385	+	Missense_Mutation	SNP	C	C	T	rs138281407	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138516385C>T	ENST00000371763.1	-	5	642	c.389G>A	c.(388-390)cGa>cAa	p.R130Q		NM_182974.2	NP_892019.2	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	130					carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	15		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		TTTGAACGTTCGAAGAGGACT	0.537000													5	47					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079286	57079286	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57079286G>A	ENST00000316981.3	-	5	1498	c.1019C>T	c.(1018-1020)tCa>tTa	p.S340L	PLAG1_ENST00000429357.2_Missense_Mutation_p.S340L|PLAG1_ENST00000423799.2_Missense_Mutation_p.S258L	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	340	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			AATTGCATATGAGGTAGAACT	0.418000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								21	194					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167517659	167517659	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167517659C>T	ENST00000519204.1	+	7	1351	c.1233C>T	c.(1231-1233)acC>acT	p.T411T	TENM2_ENST00000545108.1_Silent_p.T532T|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000518659.1_Silent_p.T532T|TENM2_ENST00000520394.1_Silent_p.T300T|TENM2_ENST00000403607.2_Silent_p.T365T					teneurin transmembrane protein 2									p.T365T(1)									GCATACAGACCTTGGTTCAGA	0.507000													36	110					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56183149	56183149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:56183149G>A	ENST00000288221.6	-	5	1416	c.1161C>T	c.(1159-1161)atC>atT	p.I387I		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	387						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CCAATGAAGCGATTTTTGTGT	0.333000													5	28					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40074023	40074023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40074023G>A	ENST00000336649.4	+	34	4983	c.4983G>A	c.(4981-4983)atG>atA	p.M1661I	CACNA1I_ENST00000407673.1_Missense_Mutation_p.M1620I|CACNA1I_ENST00000404898.1_Missense_Mutation_p.M1620I|CACNA1I_ENST00000402142.3_Missense_Mutation_p.M1655I|CACNA1I_ENST00000401624.1_Missense_Mutation_p.M1655I|CACNA1I_ENST00000400164.3_Missense_Mutation_p.M1620I			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1655					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GCGAGGGCATGAGCCGGCATG	0.637000													3	8					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26743814	26743814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26743814G>A	ENST00000529632.2	+	11	2538	c.2342G>A	c.(2341-2343)gGg>gAg	p.G781E	SEZ6L_ENST00000360929.3_Missense_Mutation_p.G781E|SEZ6L_ENST00000411842.2_5'UTR|SEZ6L_ENST00000402979.1_Missense_Mutation_p.G554E|SEZ6L_ENST00000404234.3_Missense_Mutation_p.G781E|SEZ6L_ENST00000343706.4_Missense_Mutation_p.G781E|SEZ6L_ENST00000403121.1_Missense_Mutation_p.G554E|SEZ6L_ENST00000248933.6_Missense_Mutation_p.G781E	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	781	Sushi 3.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GACATCGTGGGGAGTGACACC	0.557000													35	91					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723446	48723446	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48723446G>A	ENST00000335017.1	+	1	684	c.372G>A	c.(370-372)aaG>aaA	p.K124K		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	124					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						GGGTCTGGAAGGTTCCCAAGC	0.746000													11	20					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179571363	179571363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179571363G>A	ENST00000589042.1	-	102	29462	c.29238C>T	c.(29236-29238)ttC>ttT	p.F9746F	TTN_ENST00000342992.6_Silent_p.F8502F|TTN_ENST00000591111.1_Silent_p.F9429F|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9429	Ig-like 78.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTGGATGAAAACACGAC	0.453000													36	185					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42719404	42719404	+	Missense_Mutation	SNP	C	C	T	rs144782781		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:42719404C>T	ENST00000230882.4	+	10	1985	c.1795C>T	c.(1795-1797)Cat>Tat	p.H599Y	GHR_ENST00000357703.3_Missense_Mutation_p.H577Y|GHR_ENST00000537449.1_Missense_Mutation_p.H412Y	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	599					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TACCTCCATTCATATAGTACA	0.512000													14	44					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30705332	30705332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30705332G>A	ENST00000256246.2	-	1	1276	c.1202C>T	c.(1201-1203)tCa>tTa	p.S401L		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	401										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GTTATAAGATGAAATAACTGT	0.333000													19	99					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020463	56020463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56020463G>A	ENST00000303059.3	+	1	788	c.788G>A	c.(787-789)gGa>gAa	p.G263E		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TCTGCTAAGGGAAGGCAAAAG	0.408000													65	168					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76900491	76900491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76900491C>T	ENST00000409709.3	+	28	3878	c.3606C>T	c.(3604-3606)ttC>ttT	p.F1202F	MYO7A_ENST00000409619.2_Silent_p.F1191F|MYO7A_ENST00000458637.2_Silent_p.F1202F	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1202	MyTH4 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TGGGCTGTTTCGCCCCCTCCG	0.607000													32	79					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10231363	10231363	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10231363C>T	ENST00000377157.3	+	24	3827	c.2766C>T	c.(2764-2766)ttC>ttT	p.F922F	UBE4B_ENST00000253251.8_Silent_p.F1038F|UBE4B_ENST00000343090.6_Silent_p.F1167F	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	1167					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GTGCTCGGTTCGCGAAAGCCA	0.478000													52	115					0	0	1	0	0
ZNF786	136051	broad.mit.edu	37	7	148768966	148768966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148768966G>A	ENST00000316286.9	-	3	912	c.640C>T	c.(640-642)Cca>Tca	p.P214S	ZNF786_ENST00000491431.1_Missense_Mutation_p.P300S|ZNF786_ENST00000451334.3_Missense_Mutation_p.P263S			Q8N393	ZN786_HUMAN	zinc finger protein 786	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TTGCCGCATGGGGTGCACTGG	0.706000													8	23					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583472	88583472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88583472G>A	ENST00000339673.6	+	6	641	c.542G>A	c.(541-543)gGt>gAt	p.G181D	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.G165D|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	181					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CCTGAGGGAGGTGACTCCACT	0.587000													13	34					0	0	1	0	0
PAK3	5063	broad.mit.edu	37	X	110439146	110439146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:110439146G>A	ENST00000519681.1	+	16	1692	c.1250G>A	c.(1249-1251)gGg>gAg	p.G417E	PAK3_ENST00000417227.1_Missense_Mutation_p.G417E|PAK3_ENST00000518291.1_Missense_Mutation_p.G432E|PAK3_ENST00000360648.4_Missense_Mutation_p.G432E|PAK3_ENST00000262836.4_Missense_Mutation_p.G411E|PAK3_ENST00000372010.1_Missense_Mutation_p.G411E|PAK3_ENST00000425146.1_Missense_Mutation_p.G396E|PAK3_ENST00000446737.1_Missense_Mutation_p.G396E|PAK3_ENST00000372007.4_Missense_Mutation_p.G396E			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	411	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						ATTCTTCTCGGGATGGATGGC	0.358000										TSP Lung(19;0.15)			70	49					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53520004	53520004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:53520004C>T	ENST00000370905.3	-	2	207	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K	KLHL31_ENST00000407079.1_Missense_Mutation_p.E23K	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	23					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					GGGCTATCTTCTACGATTATA	0.418000													21	47					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6477676	6477676	+	Missense_Mutation	SNP	G	G	A	rs138597075		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6477676G>A	ENST00000525074.1	-	6	1674	c.1280C>T	c.(1279-1281)tCc>tTc	p.S427F	TRIM3_ENST00000345851.3_Missense_Mutation_p.S427F|TRIM3_ENST00000536344.1_Missense_Mutation_p.S308F|TRIM3_ENST00000529058.1_Intron|TRIM3_ENST00000359518.3_Missense_Mutation_p.S427F|TRIM3_ENST00000537602.1_Missense_Mutation_p.S349F	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	427					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCGTCCGGGGAAGGTGGCAG	0.697000													13	21					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1513989	1513989	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:1513989G>A	ENST00000389470.4	-	42	6255	c.6256C>T	c.(6256-6258)Ccc>Tcc	p.P2086S	INTS1_ENST00000404767.3_Missense_Mutation_p.P1882S			Q8N201	INT1_HUMAN	integrator complex subunit 1	1882					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCGATCATGGGCAGGTGCCTG	0.726000													6	28					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153661707	153661707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153661707G>A	ENST00000368680.3	+	17	3080	c.2608G>A	c.(2608-2610)Gaa>Aaa	p.E870K		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	870					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GGTGCAGGCCGAAGCCTTTGA	0.602000													33	106					0	0	1	0	0
GNA11	2767	broad.mit.edu	37	19	3119345	3119345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3119345C>T	ENST00000078429.4	+	6	1119	c.877C>T	c.(877-879)Ccc>Tcc	p.P293S	GNA11_ENST00000586180.1_3'UTR	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	293					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		GGACTACTTCCCCGAGTTCGA	0.632000			Mis		uveal melanoma								32	72					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118351390	118351390	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118351390G>C	ENST00000528052.1	+	3	228	c.157G>C	c.(157-159)Ggc>Cgc	p.G53R	PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.G53R|PNLIPRP1_ENST00000480870.2_3'UTR|PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.G53R|PNLIPRP1_ENST00000442761.1_Missense_Mutation_p.G53R			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	53					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		TGAGAAGATCGGCACCCGCTT	0.532000													19	156					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57333376	57333376	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57333376G>A	ENST00000361249.3	+	2	267		c.e2+1			NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGACAAAAAGGTGAGACACTT	0.493000													17	59					0	0	1	0	0
AAAS	8086	broad.mit.edu	37	12	53708591	53708591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53708591G>A	ENST00000209873.4	-	6	654	c.489C>T	c.(487-489)acC>acT	p.T163T	AAAS_ENST00000394384.3_Intron|AAAS_ENST00000549983.1_5'UTR|AAAS_ENST00000550286.1_Silent_p.T39T	NM_015665.5	NP_056480.1	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency, alacrimia	163					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	20						CAAACTTGTTGGTGTGGGGGT	0.542000													7	19					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94288954	94288954	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94288954A>G	ENST00000515393.1	-	3	949	c.950T>C	c.(949-951)gTt>gCt	p.V317A	MCTP1_ENST00000505208.1_Missense_Mutation_p.V96A|MCTP1_ENST00000429576.2_Missense_Mutation_p.V96A|MCTP1_ENST00000312216.8_Missense_Mutation_p.V96A	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	317	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		AAGATGATCAACCAGAATACA	0.353000													6	25					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78571017	78571017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:78571017C>T	ENST00000397909.2	+	27	5394	c.5221C>T	c.(5221-5223)Ccg>Tcg	p.P1741S	NAV3_ENST00000228327.6_Missense_Mutation_p.P1741S|NAV3_ENST00000536525.2_Missense_Mutation_p.P1741S|NAV3_ENST00000266692.7_Missense_Mutation_p.P1564S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1741						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTCATCCCTTCCGGCATCCCC	0.473000										HNSCC(70;0.22)			48	129					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20258009	20258009	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20258009G>A	ENST00000245957.5	+	22	2779	c.2703G>A	c.(2701-2703)gcG>gcA	p.A901A	C20orf26_ENST00000377309.2_Silent_p.A257A	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	901										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ACCGGGATGCGATCCTGGCCC	0.632000													35	106					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307866	46307866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46307866C>T	ENST00000221538.3	-	3	1439	c.1297G>A	c.(1297-1299)Gag>Aag	p.E433K	RSPH6A_ENST00000597055.1_Missense_Mutation_p.E433K|RSPH6A_ENST00000600188.1_Missense_Mutation_p.E169K	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	433						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						AGGCCCGGCTCGTTGCACACA	0.617000													20	55					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135428894	135428894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135428894C>T	ENST00000394143.1	+	6	3320	c.3029C>T	c.(3028-3030)cCt>cTt	p.P1010L	GPR112_ENST00000370652.1_Missense_Mutation_p.P1010L|GPR112_ENST00000394141.1_Missense_Mutation_p.P805L|GPR112_ENST00000412101.1_Missense_Mutation_p.P805L|GPR112_ENST00000287534.4_Missense_Mutation_p.P947L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1010					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ACCCCTGTGCCTGTTACTCAT	0.507000													76	52					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94134256	94134256	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94134256T>G	ENST00000243673.2	-	1	329	c.158A>C	c.(157-159)cAg>cCg	p.Q53P	GPR83_ENST00000539203.2_Missense_Mutation_p.Q53P	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	53						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CACAAAGTTCTGCCAGTCGGA	0.612000													13	61					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122634644	122634644	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122634644C>T	ENST00000195173.4	-	13	2085	c.1782G>A	c.(1780-1782)tgG>tgA	p.W594*	SEMA5B_ENST00000451055.2_Nonsense_Mutation_p.W648*|SEMA5B_ENST00000357599.3_Nonsense_Mutation_p.W594*			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	594					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		TGTTCTGGGTCCAGAGGCTCA	0.607000													15	64					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57113848	57113848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57113848G>A	ENST00000454682.1	-	3	1747	c.1466C>T	c.(1465-1467)gCt>gTt	p.A489V	NACA_ENST00000548563.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000550952.1_Missense_Mutation_p.A489V|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTCTTTGGGAGCCACAGGTGC	0.493000			T	BCL6	NHL								11	70					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16760838	16760838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:16760838C>T	ENST00000502640.1	-	2	326	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	LDB2_ENST00000441778.2_Missense_Mutation_p.E60K|LDB2_ENST00000304523.5_Missense_Mutation_p.E60K|LDB2_ENST00000515064.1_Missense_Mutation_p.E60K			O43679	LDB2_HUMAN	LIM domain binding 2	60							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						GCGTCATCTTCAAAAAATTCA	0.378000													28	74					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143961164	143961164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143961164C>T	ENST00000292427.4	-	1	98	c.66G>A	c.(64-66)caG>caA	p.Q22Q	CYP11B1_ENST00000517471.1_Silent_p.Q22Q|CYP11B1_ENST00000377675.3_Silent_p.Q22Q	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	22					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	TGCCCAGTGCCTGTGCCCTTT	0.642000									Familial Hyperaldosteronism type I				48	98					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617544	111617544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111617544C>T	ENST00000374667.3	-	1	1695	c.667G>A	c.(667-669)Gac>Aac	p.D223N		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	223						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CCAGCGTAGTCGGCGCGGCTG	0.657000													14	59					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177249620	177249620	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177249620C>T	ENST00000361539.4	+	8	1620	c.1308C>T	c.(1306-1308)ttC>ttT	p.F436F	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		436						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CTGGCACTTTCCTGGAACAGA	0.577000													27	74					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38557331	38557331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38557331G>A	ENST00000423485.1	-	21	2593	c.2435C>T	c.(2434-2436)tCt>tTt	p.S812F		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	812					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TCGAGCCAAAGAGCTAAAGAA	0.308000													22	18					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71482455	71482455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71482455C>T	ENST00000296755.7	+	4	682	c.384C>T	c.(382-384)atC>atT	p.I128I		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	128						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GCTTAATGATCACTGATGCTG	0.557000													37	116					0	0	1	0	0
NEDD9	4739	broad.mit.edu	37	6	11191312	11191312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:11191312G>A	ENST00000379446.5	-	5	956	c.790C>T	c.(790-792)Cct>Tct	p.P264S	RP3-510L9.1_ENST00000500636.2_RNA|NEDD9_ENST00000504387.1_Missense_Mutation_p.P264S	NM_001271033.1|NM_006403.3	NP_001257962.1|NP_006394.1	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally down-regulated 9	264					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			CAGGTTGGAGGAATGTCATAA	0.557000													19	85					0	0	1	0	0
CA6	765	broad.mit.edu	37	1	9009324	9009324	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9009324G>A	ENST00000377443.2	+	2	86	c.82G>A	c.(82-84)Ggg>Agg	p.G28R	CA6_ENST00000319474.2_Missense_Mutation_p.G28R|CA6_ENST00000377442.2_Intron|CA6_ENST00000476083.1_Intron|CA6_ENST00000377436.3_Missense_Mutation_p.G28R	NM_001215.3	NP_001206.2	P23280	CAH6_HUMAN	carbonic anhydrase VI	28					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCTTAGAAGGGGCACTGGA	0.642000													7	32					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97080982	97080982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:97080982G>A	ENST00000253262.4	-	7	2056	c.2036C>T	c.(2035-2037)cCa>cTa	p.P679L	NUTM2F_ENST00000341207.4_Missense_Mutation_p.P664L|NUTM2F_ENST00000335456.7_Intron	NM_017561.1	NP_060031.1			NUT family member 2F																		CTGAGCAGATGGAGACTGAAG	0.612000													5	11					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11666769	11666769	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11666769C>T	ENST00000262442.3	+	36	7076	c.7008C>T	c.(7006-7008)atC>atT	p.I2336I	DNAH9_ENST00000454412.2_Silent_p.I2336I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2336					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.I2336I(1)		NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTAAGAAGATCATTCCCATCC	0.498000													41	78					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34026758	34026758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34026758G>A	ENST00000374181.3	-	4	1189	c.1020C>T	c.(1018-1020)tcC>tcT	p.S340S	GRM4_ENST00000455714.2_Silent_p.S200S|GRM4_ENST00000535756.1_Silent_p.S207S|GRM4_ENST00000544773.1_Silent_p.S171S|GRM4_ENST00000545715.1_Silent_p.S32S|GRM4_ENST00000374177.3_Silent_p.S271S|GRM4_ENST00000538487.1_Silent_p.S340S	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	340					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	TACCTCGTACGGACATCCTCT	0.632000													7	24					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987555	61987555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61987555C>T	ENST00000450719.3	-	3	393	c.156G>A	c.(154-156)aaG>aaA	p.K52K	CSHL1_ENST00000438387.2_Silent_p.K63K|CSHL1_ENST00000346606.6_Silent_p.K52K|CSHL1_ENST00000309894.5_Silent_p.K146K|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000561003.1_Silent_p.K63K|CSHL1_ENST00000259003.10_Silent_p.K84K|CSHL1_ENST00000558099.1_5'UTR			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	146						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						CCTCTAGGTCCTTTAGGAGGT	0.592000													7	78					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118866123	118866123	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:118866123T>C	ENST00000295622.1	+	1	1127	c.1087T>C	c.(1087-1089)Tat>Cat	p.Y363H		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	363										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		GCTGTCTTACTATGAAACACG	0.448000													16	46					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151067847	151067847	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151067847G>A	ENST00000474524.1	+	15	2184	c.2145_splice	c.e15-1	p.D716_splice	MED12L_ENST00000491549.1_3'UTR|P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Splice_Site_p.D576_splice	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	716					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGTTTTTCAGGATGAATCTTC	0.458000													110	328					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111078149	111078149	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:111078149G>A	ENST00000262839.2	-	7	2814	c.1896_splice	c.e7+1	p.A632_splice		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	632					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGCTACTCACGGCAATAAGCT	0.443000													77	43					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153085278	153085278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153085278C>T	ENST00000285900.5	+	11	1817	c.1474C>T	c.(1474-1476)Ccc>Tcc	p.P492S	GRIA1_ENST00000518142.1_Missense_Mutation_p.P412S|GRIA1_ENST00000518783.1_Missense_Mutation_p.P502S|GRIA1_ENST00000521843.2_Missense_Mutation_p.P423S|GRIA1_ENST00000448073.4_Missense_Mutation_p.P502S|GRIA1_ENST00000340592.5_Missense_Mutation_p.P492S	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	492	Glutamate binding (By similarity).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGCTGTGGCTCCCTTAACTAT	0.358000													11	35					0	0	1	0	0
LAX1	54900	broad.mit.edu	37	1	203743176	203743176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203743176G>A	ENST00000442561.2	+	5	954	c.564G>A	c.(562-564)gaG>gaA	p.E188E	LAX1_ENST00000367215.1_3'UTR|LAX1_ENST00000367217.5_Silent_p.E172E	NM_017773.3	NP_060243.2	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1	188					B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)|endometrium(3)|large_intestine(2)|lung(13)|prostate(1)|stomach(1)|urinary_tract(2)	24	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TTTCTTCAGAGGATTCGCATG	0.493000													36	79					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372580	126372580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126372580G>A	ENST00000394329.3	+	9	10422	c.10409G>A	c.(10408-10410)cGa>cAa	p.R3470Q	FAT4_ENST00000335110.5_Missense_Mutation_p.R1768Q	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3470	Cadherin 33.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAATTAGATCGAGAAACCCTT	0.443000													52	118					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108622612	108622612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108622612G>A	ENST00000264047.2	+	7	1125	c.849G>A	c.(847-849)gtG>gtA	p.V283V	SLC5A7_ENST00000409059.1_Silent_p.V283V|SLC5A7_ENST00000540517.1_Silent_p.V178V	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	283					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	GGTGCCTGGTGATGGCCATCC	0.527000													33	76					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18829902	18829902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18829902G>A	ENST00000380548.4	+	23	4515	c.4176G>A	c.(4174-4176)ccG>ccA	p.P1392P	ADAMTSL1_ENST00000380545.5_Silent_p.P93P	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1392						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCACTGGACCGAACCTTCCTT	0.567000													13	27					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6244522	6244522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6244522G>A	ENST00000400104.3	-	6	485	c.285C>T	c.(283-285)ccC>ccT	p.P95P	L3MBTL4_ENST00000400105.2_Silent_p.P95P|L3MBTL4_ENST00000284898.6_Silent_p.P95P|L3MBTL4_ENST00000317931.7_Silent_p.P95P			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	95					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				ATGGATGTCGGGGATCAATGC	0.418000													68	149					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37486340	37486340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37486340C>T	ENST00000374660.1	+	35	2936	c.2837C>T	c.(2836-2838)gCc>gTc	p.A946V	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.A827V|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.A827V			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	997						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.A827V(1)		NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATTTAGCCTGCCATTGAAATG	0.308000													36	103					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380062	56380062	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56380062C>A	ENST00000526538.1	-	1	916	c.917G>T	c.(916-918)aGg>aTg	p.R306M		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						GGATTTTCCCCTAATCATTTG	0.373000													29	195					2.14196e-07	2.14784e-07	1	1	0
CEP44	80817	broad.mit.edu	37	4	175224908	175224908	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175224908C>T	ENST00000503780.1	+	5	706	c.292C>T	c.(292-294)Caa>Taa	p.Q98*	CEP44_ENST00000457424.2_Nonsense_Mutation_p.Q98*|CEP44_ENST00000296519.4_Nonsense_Mutation_p.Q98*|CEP44_ENST00000426172.1_Nonsense_Mutation_p.Q98*	NM_001040157.2	NP_001035247.1	Q9C0F1	CEP44_HUMAN	centrosomal protein 44kDa	98						centrosome|midbody|spindle pole				endometrium(2)|large_intestine(4)|lung(5)|stomach(1)	12						GCAGTTTATCCAATGTGGGTT	0.318000													15	42					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158607975	158607975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158607975G>A	ENST00000368148.3	-	36	5217	c.5037C>T	c.(5035-5037)ttC>ttT	p.F1679F	SPTA1_ENST00000368147.3_Silent_p.F1679F	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1679					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GATCAACGTTGAAAGTCCCGC	0.423000													22	35					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196871677	196871677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196871677C>T	ENST00000367416.2	+	2	322	c.185C>T	c.(184-186)cCt>cTt	p.P62L	CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000251424.4_Missense_Mutation_p.P63L|CFHR4_ENST00000367418.1_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						TTTGTGACTCCTTCAGGAAGT	0.398000													56	158					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22313149	22313149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22313149C>T	ENST00000337107.6	+	7	787	c.768C>T	c.(766-768)gtC>gtT	p.V256V	CELA3B_ENST00000473526.1_3'UTR	NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	256	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						TCACTCGAGTCTCCGCCTTCA	0.607000													12	51					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9066649	9066649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:9066649C>T	ENST00000382496.5	-	17	2848	c.2183G>A	c.(2182-2184)cGa>cAa	p.R728Q		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	728	TSP type-1 4.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GTATCGGAATCGTTGCTCATA	0.547000													53	115					0	0	1	0	0
ZFP28	140612	broad.mit.edu	37	19	57065579	57065579	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57065579C>T	ENST00000301318.3	+	8	1496	c.1425C>T	c.(1423-1425)ccC>ccT	p.P475P	AC007228.11_ENST00000596587.1_RNA	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GCAAGAAGCCCTATGAGTGCA	0.463000													22	64					0	0	1	0	0
OR51A2	401667	broad.mit.edu	37	11	4976592	4976592	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4976592G>A	ENST00000380371.1	-	1	351	c.352C>T	c.(352-354)Ctg>Ttg	p.L118L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004748.1	NP_001004748.1	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACATGATCAGGAGGACTGAG	0.448000													23	25					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55080480	55080480	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55080480G>A	ENST00000302250.2	-	4	628	c.468C>T	c.(466-468)ctC>ctT	p.L156L	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Silent_p.L156L	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	156						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						GCTGCCGCAGGAGGTCCAGGG	0.552000													14	52					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53398087	53398087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:53398087C>T	ENST00000226067.5	+	4	1208	c.735C>T	c.(733-735)gcC>gcT	p.A245A	HLF_ENST00000430986.2_Silent_p.A160A|HLF_ENST00000575307.1_3'UTR|HLF_ENST00000573945.1_Silent_p.A160A|HLF_ENST00000575345.1_Silent_p.A160A	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	245					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						CCCGCGACGCCCGGAGGCTGA	0.567000			T	TCF3	ALL								11	42					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922993	24922993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922993C>T	ENST00000329468.2	+	1	2453	c.1979C>T	c.(1978-1980)tCt>tTt	p.S660F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CAGAAAGCTTCTCTCCCCAGT	0.498000													22	160					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436263	248436263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248436263G>A	ENST00000318021.2	-	1	875	c.854C>T	c.(853-855)cCc>cTc	p.P285L		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P285L(1)		NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTAGATGAGGGGGTTTAGTAA	0.478000													47	232					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139873743	139873743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139873743G>A	ENST00000224167.2	+	3	398	c.323G>A	c.(322-324)cGg>cAg	p.R108Q	PTGDS_ENST00000371625.3_Missense_Mutation_p.R108Q|PTGDS_ENST00000460340.1_3'UTR			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	108					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TACAGCTACCGGAGTCCCCGT	0.687000													23	62					0	0	1	0	0
ANKRD13A	88455	broad.mit.edu	37	12	110463606	110463606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110463606G>A	ENST00000261739.4	+	8	1027	c.861G>A	c.(859-861)gaG>gaA	p.E287E		NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	287										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						ATCTGACCGAGGAGGAAAAAA	0.413000													43	95					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808058	18808058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18808058G>A	ENST00000400664.1	+	1	635	c.583G>A	c.(583-585)Gag>Aag	p.E195K		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	195						integral to membrane		p.E195K(1)		endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TAAACCCCGTGAGCATCCAGG	0.612000													17	51					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10756197	10756197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10756197C>T	ENST00000416569.2	-	3	1217	c.1191G>A	c.(1189-1191)atG>atA	p.M397I	XKR6_ENST00000304437.2_Missense_Mutation_p.M118I	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	397						integral to membrane		p.M397I(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		TCCAGAAGGCCATGGCGCACC	0.512000													7	60					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7569539	7569539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7569539C>T	ENST00000379802.3	+	12	1881	c.1540C>T	c.(1540-1542)Cct>Tct	p.P514S	DSP_ENST00000418664.2_Missense_Mutation_p.P514S	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	514	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GATCATCCCTCCTCCGAACCC	0.577000													25	96					0	0	1	0	0
CA13	377677	broad.mit.edu	37	8	86163062	86163062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:86163062C>T	ENST00000321764.3	+	2	433	c.131C>T	c.(130-132)tCc>tTc	p.S44F	CA13_ENST00000517298.1_3'UTR	NM_198584.2	NP_940986.1	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	44					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			large_intestine(1)|lung(6)	7						TATGACTCTTCCCTCCGACCA	0.398000													66	140					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778460	31778460	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31778460G>A	ENST00000375654.4	-	2	1479	c.1290C>T	c.(1288-1290)ttC>ttT	p.F430F	HSPA1L_ENST00000417199.3_Silent_p.F430F	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	430					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						AGTAGGTGGTGAAAATCTGTG	0.597000													81	158					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411138	23411138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23411138G>A	ENST00000379361.4	+	3	2363	c.1503G>A	c.(1501-1503)aaG>aaA	p.K501K		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	501					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						CCTATGTCAAGCCTTTTGTAG	0.428000													81	57					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219894230	219894230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219894230G>A	ENST00000341552.5	-	11	1628	c.1545C>T	c.(1543-1545)gcC>gcT	p.A515A	CCDC108_ENST00000453220.1_Silent_p.A515A|CCDC108_ENST00000410037.1_Silent_p.A450A|CCDC108_ENST00000409865.3_Silent_p.A504A|CCDC108_ENST00000441968.1_Silent_p.A515A	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	515						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGTCCCAAAGGCAGGCCTGA	0.602000											OREG0015211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	32					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54535277	54535277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54535277C>T	ENST00000566473.2	+	13	1503	c.1503C>T	c.(1501-1503)tcC>tcT	p.S501S	ANKFN1_ENST00000318698.2_Silent_p.S501S			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	501										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						TACCAATATCCTCATCCTCAT	0.502000													35	74					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94109943	94109943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94109943G>A	ENST00000553484.1	+	36	6281	c.6127G>A	c.(6127-6129)Gag>Aag	p.E2043K	UNC79_ENST00000555664.1_Missense_Mutation_p.E1982K|UNC79_ENST00000256339.4_Missense_Mutation_p.E1844K|UNC79_ENST00000393151.2_Missense_Mutation_p.E2021K			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2021						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ATACGATGAAGAGACACTTGG	0.483000													36	71					0	0	1	0	0
C9orf129	445577	broad.mit.edu	37	9	96097715	96097715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96097715G>A	ENST00000375419.1	-	3	669	c.306C>T	c.(304-306)ttC>ttT	p.F102F		NM_001098808.1	NP_001092278.1	Q5T035	CI129_HUMAN	chromosome 9 open reading frame 129	102										endometrium(2)|large_intestine(1)|lung(1)|ovary(2)	6						AAGAGCCAGGGAAGTAGGCGG	0.627000													12	36					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48620047	48620047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48620047G>A	ENST00000328333.8	-	44	4665	c.4558C>T	c.(4558-4560)Cct>Tct	p.P1520S	COL7A1_ENST00000454817.1_Missense_Mutation_p.P1520S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1520	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCACTTCAGGACCCTTGGCT	0.602000													15	54					0	0	1	0	0
PER2	8864	broad.mit.edu	37	2	239181733	239181733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239181733G>A	ENST00000254657.3	-	5	827	c.548C>T	c.(547-549)tCt>tTt	p.S183F	PER2_ENST00000355768.2_Missense_Mutation_p.S183F|PER2_ENST00000254658.3_Missense_Mutation_p.S183F|PER2_ENST00000440245.1_Missense_Mutation_p.S183F	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	183	PAS 1.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		AATGTGCTCAGAGGTAACGCT	0.552000													22	58					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285643	223285643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:223285643C>T	ENST00000540964.1	-	4	1192	c.731G>A	c.(730-732)gGa>gAa	p.G244E	TLR5_ENST00000342210.6_Missense_Mutation_p.G244E			O60602	TLR5_HUMAN	toll-like receptor 5	244					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		GCTAAAGTTTCCTGTGATGTC	0.468000													41	107					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	173024	173024	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:173024G>A	ENST00000283426.6	+	15	3045	c.2995G>A	c.(2995-2997)Gaa>Aaa	p.E999K		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	999	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GAATTTGAAGGAACAGGGGCA	0.498000													31	74					0	0	1	0	0
POU4F2	5458	broad.mit.edu	37	4	147561322	147561322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:147561322C>T	ENST00000281321.3	+	2	840	c.592C>T	c.(592-594)Ccc>Tcc	p.P198S		NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	198					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					GCACCTGAGTCCCGGGCTGGC	0.711000													4	10					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200967679	200967679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200967679G>A	ENST00000332129.2	-	14	2226	c.1910C>T	c.(1909-1911)gCc>gTc	p.A637V	KIF21B_ENST00000360529.5_Missense_Mutation_p.A637V|KIF21B_ENST00000461742.2_Missense_Mutation_p.A637V|KIF21B_ENST00000422435.2_Missense_Mutation_p.A637V	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	637					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						AGTCAGGTCGGCCAGGTCCGC	0.587000													27	61					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88658671	88658671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:88658671G>A	ENST00000340700.5	-	5	1201	c.750C>T	c.(748-750)atC>atT	p.I250I	KCNK10_ENST00000312350.5_Silent_p.I255I|KCNK10_ENST00000319231.5_Silent_p.I255I	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	250					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						TGACAGCAGGGATCGTCACAA	0.502000													33	112					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101183219	101183219	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101183219G>A	ENST00000313669.7	+	0	685				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		CCCGGACAACGACCTGCCAGC	0.632000													12	43					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35874645	35874645	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35874645G>A	ENST00000303115.3	+	6	929		c.e6+1		IL7R_ENST00000506850.1_Intron|IL7R_ENST00000343305.4_Intron	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor						immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GGAAAAAAAGGTGACCTTCTT	0.428000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						26	84					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16276673	16276673	+	Silent	SNP	G	G	A	rs57866002		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16276673G>A	ENST00000205557.7	-	16	2087	c.2058C>T	c.(2056-2058)ttC>ttT	p.F686F	ABCC6_ENST00000574094.1_Intron	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	686	ABC transporter 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CGATGCTCACGAACCCCTCCA	0.652000													18	49					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151105886	151105886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151105886G>A	ENST00000341697.3	-	19	3558	c.1867C>T	c.(1867-1869)Ctc>Ttc	p.L623F				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	623						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGACCAGGAGGCCAGAGACT	0.721000													4	15					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834783	125834783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125834783G>A	ENST00000299308.3	+	2	846	c.838G>A	c.(838-840)Gag>Aag	p.E280K		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	280						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAGCTTGGACGAGAATGTGGT	0.567000													63	157					0	0	1	0	0
RIPPLY2	134701	broad.mit.edu	37	6	84567100	84567100	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:84567100G>A	ENST00000369689.1	+	4	530	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	RIPPLY2_ENST00000369687.1_Missense_Mutation_p.E69K	NM_001009994.1	NP_001009994.1	Q5TAB7	RIPP2_HUMAN	ripply transcriptional repressor 2	127					somite rostral/caudal axis specification	nucleus				large_intestine(2)|lung(4)|urinary_tract(1)	7						TCTGACCTGTGAAAATTAATC	0.289000													30	63					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166893029	166893029	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166893029G>A	ENST00000423058.2	-	16	2975	c.2958C>T	c.(2956-2958)ctC>ctT	p.L986L	SCN1A_ENST00000409050.1_Silent_p.L958L|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Silent_p.L975L|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Silent_p.L986L	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	986			L -> F (in SMEI; complete loss of function; dbSNP:rs121918625).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGGCCAGAAAGAGATTCAGGA	0.363000													13	37					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037935	75037935	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75037935C>T	ENST00000326665.5	-	14	3677	c.3459G>A	c.(3457-3459)gtG>gtA	p.V1153V	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1153	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						ATATGGGAACCACTGTCTCTT	0.468000													24	76					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14561721	14561721	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14561721G>A	ENST00000273083.3	-	0	991							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CTCAAGCAGCGAGCAGTGTTC	0.647000													6	34					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69416525	69416525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69416525G>A	ENST00000317746.2	-	5	1225	c.1183C>T	c.(1183-1185)Ccc>Tcc	p.P395S		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	395					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						GCAAACAAGGGAATGCCCACC	0.458000													75	119					0	0	1	0	0
IL17RC	84818	broad.mit.edu	37	3	9959119	9959119	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9959119C>T	ENST00000295981.3	+	1	338	c.120C>T	c.(118-120)ccC>ccT	p.P40P	IL17RC_ENST00000383812.4_Intron|IL17RC_ENST00000416074.2_Intron|IL17RC_ENST00000413608.1_Intron|IL17RC_ENST00000498214.1_Intron|IL17RC_ENST00000403601.3_Intron|IL17RC_ENST00000455057.1_Intron	NM_153461.3	NP_703191.1	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C	40						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GTCTGGAACCCTGGGGAGACG	0.607000													17	55					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075309	106075309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106075309G>A	ENST00000278071.2	-	3	953	c.501C>T	c.(499-501)ttC>ttT	p.F167F	ITPRIP_ENST00000358187.2_Silent_p.F167F|ITPRIP_ENST00000337478.1_Silent_p.F167F	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	167						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						AGTCATCCACGAAGCCTTCCA	0.622000													32	76					0	0	1	0	0
DCAF7	10238	broad.mit.edu	37	17	61660954	61660954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61660954C>T	ENST00000310827.4	+	6	836	c.619C>T	c.(619-621)Cgc>Tgc	p.R207C	DCAF7_ENST00000431926.1_Intron|DCAF7_ENST00000577702.1_3'UTR|DCAF7_ENST00000415273.2_Intron	NM_005828.3	NP_005819.3	P61962	DCAF7_HUMAN	DDB1 and CUL4 associated factor 7	207					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)	18						GTTTGACCTCCGCCATCTAGA	0.562000													19	36					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669197	234669197	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234669197G>A	ENST00000360418.3	+	1	264	c.264G>A	c.(262-264)gtG>gtA	p.V88V	UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A1_ENST00000305208.5_Silent_p.V88V|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A10_ENST00000373445.1_Intron			P22309	UD11_HUMAN		88					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	GGGAGGATGTGAAAGAGTCTT	0.418000													59	160					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13150667	13150667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:13150667G>A	ENST00000319217.7	-	25	3720	c.3473C>T	c.(3472-3474)cCa>cTa	p.P1158L	MPDZ_ENST00000381015.4_Missense_Mutation_p.P1158L|MPDZ_ENST00000538841.1_Missense_Mutation_p.P50L|MPDZ_ENST00000447879.1_Missense_Mutation_p.P1158L|MPDZ_ENST00000381022.2_Missense_Mutation_p.P1158L|MPDZ_ENST00000541718.1_Missense_Mutation_p.P1158L|MPDZ_ENST00000536827.1_Missense_Mutation_p.P1158L|MPDZ_ENST00000546205.1_Missense_Mutation_p.P1172L	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1158	PDZ 7.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		GGATTTGCTTGGTTCTCTCCA	0.403000													15	34					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70555477	70555477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70555477G>A	ENST00000310961.5	+	25	4698	c.4280G>A	c.(4279-4281)gGa>gAa	p.G1427E	LRRC7_ENST00000035383.5_Missense_Mutation_p.G1469E|LRRC7_ENST00000415775.2_Missense_Mutation_p.G753E			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1469						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGTGGACAAGGAAATCCATTC	0.303000													23	77					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186026368	186026368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186026368C>T	ENST00000271588.4	+	46	7376	c.7147C>T	c.(7147-7149)Cct>Tct	p.P2383S	HMCN1_ENST00000367492.2_Missense_Mutation_p.P2383S	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2383					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCTTACAGCTCCTCCAAGCAT	0.368000													19	49					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085498	9085498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9085498G>A	ENST00000397910.4	-	1	6520	c.6317C>T	c.(6316-6318)cCa>cTa	p.P2106L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2106	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTGTTTCTGGATTTCTTTG	0.498000													50	152					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62586953	62586953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62586953C>T	ENST00000371158.2	+	38	5105	c.4991C>T	c.(4990-4992)tCc>tTc	p.S1664F	INADL_ENST00000472512.1_3'UTR	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1664					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TCAGATCCTTCCCAGAAAAAT	0.423000													28	73					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27528597	27528597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27528597G>A	ENST00000301904.3	+	6	1570	c.1550G>A	c.(1549-1551)gGg>gAg	p.G517E	SCARA3_ENST00000337221.4_Intron	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	517					response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		GGCCCTCGAGGGTTCCCAGGC	0.687000													5	20					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282624	152282624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152282624C>T	ENST00000368799.1	-	3	4773	c.4738G>A	c.(4738-4740)Gaa>Aaa	p.E1580K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1580	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCGCTGATTCTCCCTGGCCC	0.597000									Ichthyosis				127	261					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39817998	39817998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:39817998C>T	ENST00000553728.1	+	27	3883	c.3670C>T	c.(3670-3672)Cct>Tct	p.P1224S	CTAGE5_ENST00000280083.3_Missense_Mutation_p.P689S|CTAGE5_ENST00000396165.4_Missense_Mutation_p.P660S|CTAGE5_ENST00000556148.1_Missense_Mutation_p.P614S|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.P660S|CTAGE5_ENST00000341502.5_Missense_Mutation_p.P689S|CTAGE5_ENST00000396158.2_Missense_Mutation_p.P694S|CTAGE5_ENST00000341749.3_Missense_Mutation_p.P677S|CTAGE5_ENST00000553383.1_3'UTR|CTAGE5_ENST00000348007.3_Missense_Mutation_p.P646S|CTAGE5_ENST00000557038.1_Missense_Mutation_p.P609S|CTAGE5_ENST00000553352.1_Missense_Mutation_p.P660S																							AGCCACTGGCCCTGGCTTTGT	0.463000													47	360					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150488671	150488671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150488671G>A	ENST00000447204.2	-	7	1133	c.761C>T	c.(760-762)tCa>tTa	p.S254L	TMEM176B_ENST00000492607.1_Missense_Mutation_p.S254L|TMEM176B_ENST00000450753.2_Missense_Mutation_p.S217L|TMEM176B_ENST00000326442.5_Missense_Mutation_p.S254L|TMEM176B_ENST00000434545.1_Missense_Mutation_p.S254L|TMEM176B_ENST00000429904.2_Missense_Mutation_p.S254L	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	254					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGGGCACTGAATTCTCCCC	0.532000													19	62					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2411133	2411133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2411133G>A	ENST00000202625.2	+	11	1781	c.1720G>A	c.(1720-1722)Gaa>Aaa	p.E574K	TGM6_ENST00000381423.1_Missense_Mutation_p.E574K	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	574					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	TAAGTATAAAGAAGACCTGAC	0.458000													42	96					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28194205	28194205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:28194205G>A	ENST00000302326.4	-	1	3281	c.2327C>T	c.(2326-2328)tCt>tTt	p.S776F		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	776							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						GCCGCCACCAGAGCTGCCACC	0.736000			T	ETV6	"""AML, meningioma"""								5	8					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136635505	136635505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136635505G>A	ENST00000371851.1	-	25	2637	c.2312C>T	c.(2311-2313)tCc>tTc	p.S771F	VAV2_ENST00000406606.3_Missense_Mutation_p.S771F|VAV2_ENST00000371850.3_Missense_Mutation_p.S781F			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	781					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GTTACCTGGGGACCGGCTGGA	0.657000													13	44					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724857	49724857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49724857C>T	ENST00000551245.1	+	13	2340	c.2229C>T	c.(2227-2229)ctC>ctT	p.L743L	TROAP_ENST00000257909.3_Intron|TROAP_ENST00000547923.1_Intron			Q12815	TROAP_HUMAN	trophinin associated protein	0					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						GCCTGGCTCTCCCTCAGGAAG	0.607000													3	9					0	0	1	0	0
HMP19	51617	broad.mit.edu	37	5	173531281	173531281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:173531281C>T	ENST00000303177.3	+	4	526	c.264C>T	c.(262-264)ttC>ttT	p.F88F	NSG2_ENST00000521585.1_Intron|NSG2_ENST00000521959.1_3'UTR	NM_015980.4	NP_057064.1																					GCATCGTGTTCCTGGTGGTTT	0.498000													30	57					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17699041	17699041	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:17699041C>T	ENST00000353383.1	+	3	3248	c.2779C>T	c.(2779-2781)Ctg>Ttg	p.L927L	RAI1_ENST00000261641.6_Silent_p.L927L	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	927						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		GTCCGTCATCCTGCTGGGCCC	0.632000													13	29					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221357	161221357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161221357C>T	ENST00000327928.4	+	4	1061	c.1061C>T	c.(1060-1062)cCt>cTt	p.P354L		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	354	C1q.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AAGCCATTTCCTCCTCCTAAC	0.498000													15	30					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97192281	97192281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97192281G>A	ENST00000371247.2	-	6	414	c.225C>T	c.(223-225)gcC>gcT	p.A75A	SORBS1_ENST00000277982.5_Silent_p.A75A|SORBS1_ENST00000306402.6_Silent_p.A75A|SORBS1_ENST00000361941.3_Silent_p.A75A|SORBS1_ENST00000607232.1_Silent_p.A43A|SORBS1_ENST00000371241.1_Silent_p.A43A|SORBS1_ENST00000347291.4_Silent_p.A75A|SORBS1_ENST00000354106.3_Silent_p.A75A|SORBS1_ENST00000371245.3_Silent_p.A75A|SORBS1_ENST00000371246.2_Silent_p.A75A|SORBS1_ENST00000371227.4_Silent_p.A75A|SORBS1_ENST00000371239.1_Silent_p.A43A|SORBS1_ENST00000353505.5_Silent_p.A75A|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000371249.2_Silent_p.A43A|SORBS1_ENST00000393949.1_Silent_p.A75A			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	75					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		AGGAAGACGAGGCCCGGAGAG	0.527000													44	68					0	0	1	0	0
PTPN7	5778	broad.mit.edu	37	1	202128409	202128409	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202128409C>T	ENST00000309017.3	-	2	1210	c.437_splice	c.e2+1	p.R146_splice	PTPN7_ENST00000367279.4_Splice_Site_p.R80_splice|PTPN7_ENST00000308986.5_Splice_Site_p.R41_splice|PTPN7_ENST00000544762.1_5'UTR|PTPN7_ENST00000543735.1_5'UTR	NM_001199797.1|NM_002832.3	NP_001186726.1|NP_002823.3	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7	41	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						AAGATCTCACCTCTCCTGCAG	0.627000													6	41					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348028	140348028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348028G>A	ENST00000289269.5	+	1	2209	c.1677G>A	c.(1675-1677)ctG>ctA	p.L559L	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		559	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCACCACTGAGCAGCACTG	0.527000													26	75					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907685	12907685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12907685G>A	ENST00000317869.6	-	2	683	c.458C>T	c.(457-459)tCa>tTa	p.S153L		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						GCCCCTTCGTGAGGTGTTTCC	0.498000													66	395					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93119327	93119327	+	Missense_Mutation	SNP	C	C	T	rs142007147		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93119327C>T	ENST00000216487.7	+	6	2092	c.1933C>T	c.(1933-1935)Cgc>Tgc	p.R645C	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	645	Interaction with RAB5B.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding	p.R645C(1)		endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				GCAGGAGATTCGCACCATGAT	0.622000													15	37					0	0	1	0	0
DBT	1629	broad.mit.edu	37	1	100672014	100672014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100672014G>A	ENST00000370132.3	-	9	1209	c.1196C>T	c.(1195-1197)tCc>tTc	p.S399F		NM_001918.3	NP_001909.3	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase E2	399					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(1)	19		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TCCAATGTTGGAAAGAGTAAA	0.373000													55	159					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19747261	19747261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:19747261C>T	ENST00000507958.1	-	6	1303	c.313G>A	c.(313-315)Gat>Aat	p.D105N	CDH18_ENST00000506372.1_Missense_Mutation_p.D105N|CDH18_ENST00000382275.1_Missense_Mutation_p.D105N|CDH18_ENST00000274170.4_Missense_Mutation_p.D105N|CDH18_ENST00000502796.1_Missense_Mutation_p.D105N|CDH18_ENST00000511273.1_Missense_Mutation_p.D105N			Q13634	CAD18_HUMAN	cadherin 18, type 2	105	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.D104_D105>EY(2)|p.D105Y(2)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CCCGTGGTATCGTCAATGATA	0.438000													28	86					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651679	1651679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1651679C>T	ENST00000399676.2	+	1	647	c.609C>T	c.(607-609)agC>agT	p.S203S		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	203	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCCTGTAGCTGCTTCTCAG	0.592000													57	178					0	0	1	0	0
SPATA22	84690	broad.mit.edu	37	17	3346535	3346535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3346535G>A	ENST00000573128.1	-	8	1316	c.833C>T	c.(832-834)cCa>cTa	p.P278L	SPATA22_ENST00000572969.1_Missense_Mutation_p.P278L|SPATA22_ENST00000268981.5_Intron|SPATA22_ENST00000397168.3_Missense_Mutation_p.P278L|SPATA22_ENST00000355380.4_Missense_Mutation_p.P235L|SPATA22_ENST00000575375.1_Missense_Mutation_p.P278L|SPATA22_ENST00000541913.1_Missense_Mutation_p.P262L			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	278										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						CGAATAATATGGGCCAGGTGT	0.353000													14	25					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96967005	96967005	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96967005G>A	ENST00000341686.3	+	4	569	c.444G>A	c.(442-444)aaG>aaA	p.K148K	C10orf129_ENST00000394005.3_Silent_p.K148K|C10orf129_ENST00000430183.1_5'UTR	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	148					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		TGACTGCCAAGAAAATTCGCT	0.463000													10	77					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234845968	234845968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234845968C>T	ENST00000355722.4	+	3	127	c.13C>T	c.(13-15)Ctt>Ttt	p.L5F	TRPM8_ENST00000324695.4_Intron|TRPM8_ENST00000409625.1_Intron|TRPM8_ENST00000433712.2_Intron			Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	0						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GAAATCCTTCCTTCCTGTCCA	0.438000													12	53					0	0	1	0	0
SLC44A1	23446	broad.mit.edu	37	9	108127887	108127887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:108127887C>T	ENST00000374720.3	+	11	1624	c.1377C>T	c.(1375-1377)atC>atT	p.I459I	SLC44A1_ENST00000374723.1_Silent_p.I459I|SLC44A1_ENST00000374724.1_Silent_p.I459I|SLC44A1_ENST00000343170.7_Silent_p.I251I	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	459						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	CGCGAATGATCCTTATGTATA	0.408000													31	100					0	0	1	0	0
GKN1	56287	broad.mit.edu	37	2	69204639	69204639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69204639G>A	ENST00000377938.2	+	2	130	c.67G>A	c.(67-69)Gga>Aga	p.G23R		NM_019617.3	NP_062563.3	Q9NS71	GKN1_HUMAN	gastrokine 1	23					digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						TGTCTTTGCTGGACTTCTTGG	0.373000													36	111					0	0	1	0	0
DHDH	27294	broad.mit.edu	37	19	49438278	49438278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49438278G>A	ENST00000221403.2	+	2	152	c.112G>A	c.(112-114)Gat>Aat	p.D38N	DHDH_ENST00000522614.1_Missense_Mutation_p.D38N|DHDH_ENST00000523250.1_Missense_Mutation_p.D38N	NM_014475.3	NP_055290.1	Q9UQ10	DHDH_HUMAN	dihydrodiol dehydrogenase (dimeric)	38					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			central_nervous_system(1)|large_intestine(3)|lung(3)|ovary(1)|soft_tissue(1)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		GGCGGCCCGCGATCTGAGCCG	0.637000													4	10					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60741965	60741965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60741965G>A	ENST00000303375.5	+	2	577	c.175G>A	c.(175-177)Ggc>Agc	p.G59S		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	59	Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GGAGGCCCAGGGCGGGCAGGT	0.617000													35	98					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906452	13906452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13906452G>A	ENST00000279593.3	-	3	1018	c.809C>T	c.(808-810)cCt>cTt	p.P270L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	270					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAACTCCGCAGGCACTGTGTC	0.547000													14	61					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26346380	26346380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26346380G>A	ENST00000335473.7	+	37	6046	c.5796G>A	c.(5794-5796)gaG>gaA	p.E1932E	MYO18B_ENST00000536101.1_Silent_p.E1932E|MYO18B_ENST00000407587.2_Silent_p.E1933E	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1932	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TGCAGCTGGAGGAAGCCAAGA	0.438000													6	24					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736281	12736281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:12736281G>A	ENST00000380682.1	+	16	3842	c.3336G>A	c.(3334-3336)ggG>ggA	p.G1112G		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1112					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CAGCAACAGGGAAAACCTTTC	0.507000													72	40					0	0	1	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047502	46047502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46047502G>A	ENST00000397911.3	+	1	463	c.414G>A	c.(412-414)ccG>ccA	p.P138P	KRTAP10-9_ENST00000484861.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198690.2	NP_941963.2	P60411	KR109_HUMAN	keratin associated protein 10-9	138	25 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9						cctgccagccggcctgctgtg	0.612000													35	251					0	0	1	0	0
IRAK3	11213	broad.mit.edu	37	12	66611005	66611005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:66611005G>A	ENST00000261233.4	+	6	1064	c.643G>A	c.(643-645)Gtt>Att	p.V215I	IRAK3_ENST00000457197.2_Missense_Mutation_p.V154I	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	215	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		TGAGCTTGAAGTTTTACTACT	0.363000													167	658					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140564245	140564245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140564245C>T	ENST00000361016.2	+	1	3266	c.2111C>T	c.(2110-2112)tCg>tTg	p.S704L		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		704					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCCTCTTTTCGGTGCTCCTG	0.697000													79	139					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532053	50532053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50532053C>T	ENST00000374144.3	+	3	1751	c.1463C>T	c.(1462-1464)tCt>tTt	p.S488F	C10orf71_ENST00000323868.4_Missense_Mutation_p.S488F			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	488										endometrium(1)	1						GAATGTCAGTCTCGAGACAGC	0.547000													4	25					0	0	1	0	0
CLC	1178	broad.mit.edu	37	19	40225045	40225045	+	Missense_Mutation	SNP	G	G	A	rs149971661	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40225045G>A	ENST00000221804.4	-	3	256	c.181C>T	c.(181-183)Cgt>Tgt	p.R61C		NM_001828.5	NP_001819.2	Q05315	LPPL_HUMAN	Charcot-Leyden crystal galectin	61	Galectin.				lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(2)|stomach(1)	12	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)		ATGACCACACGACGACCAAAG	0.493000													55	137					0	0	1	0	0
AARS	16	broad.mit.edu	37	16	70298899	70298899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70298899G>A	ENST00000261772.8	-	11	1597	c.1454C>T	c.(1453-1455)cCa>cTa	p.P485L		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	485					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	ATTGTACTTTGGGGAATCATC	0.517000													22	37					0	0	1	0	0
SBNO2	22904	broad.mit.edu	37	19	1119586	1119586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1119586G>A	ENST00000361757.3	-	13	1539	c.1302C>T	c.(1300-1302)agC>agT	p.S434S	SBNO2_ENST00000438103.2_Silent_p.S377S|SBNO2_ENST00000587024.1_Silent_p.S434S	NM_014963.2	NP_055778.2	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 (Drosophila)	434					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent					NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACCCAAGCGGCTCATGTAGA	0.647000													6	14					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57137380	57137380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57137380C>T	ENST00000263314.2	+	12	1138	c.1104C>T	c.(1102-1104)atC>atT	p.I368I		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	368					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity	p.I368M(1)		endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						CGCTGAAAATCGCGGCTTTGA	0.547000													5	49					0	0	1	0	0
IHH	3549	broad.mit.edu	37	2	219920427	219920427	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219920427G>A	ENST00000295731.5	-	3	737	c.738C>T	c.(736-738)ttC>ttT	p.F246F		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	246				F -> L (in Ref. 1; BAA33523).	cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCGGTCCAGGAAAATGAGCA	0.657000													23	57					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133543015	133543015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133543015G>A	ENST00000409261.1	-	14	1742	c.1369C>T	c.(1369-1371)Ctg>Ttg	p.L457L	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Silent_p.L457L	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	457							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GGGCTCCCCAGGTCAGCTGTT	0.473000													13	45					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158914789	158914789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158914789C>T	ENST00000368140.1	+	7	1561	c.1316C>T	c.(1315-1317)cCt>cTt	p.P439L	PYHIN1_ENST00000485134.1_3'UTR|PYHIN1_ENST00000392254.2_Missense_Mutation_p.P439L|PYHIN1_ENST00000368138.3_Missense_Mutation_p.P430L|PYHIN1_ENST00000392252.3_Missense_Mutation_p.P430L	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	439					cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					CTCAAGACTCCTCAGATGCCA	0.493000													39	133					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4432134	4432134	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4432134C>T	ENST00000301280.5	+	12	2234	c.2133C>T	c.(2131-2133)ttC>ttT	p.F711F	CHAF1A_ENST00000587368.1_3'UTR	NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	711	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCTGCTTCCTGGAGACCC	0.662000								Chromatin Structure					14	46					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3511995	3511995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3511995C>T	ENST00000356575.4	-	3	509	c.283G>A	c.(283-285)Ggc>Agc	p.G95S		NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	95	EMI.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TGCCTGTAGCCCATGTAGTAG	0.612000													8	77					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111146191	111146191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111146191G>A	ENST00000485317.1	-	3	1887	c.1214C>T	c.(1213-1215)cCg>cTg	p.P405L	KCNA2_ENST00000440270.1_Missense_Mutation_p.P405L|KCNA2_ENST00000316361.4_Missense_Mutation_p.P405L|KCNA2_ENST00000369770.3_Intron			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	405						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		GACAGGGACCGGTAAGGCAAT	0.488000													15	106					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10480303	10480303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10480303C>T	ENST00000382483.3	-	2	632	c.409G>A	c.(409-411)Gaa>Aaa	p.E137K	RP1L1_ENST00000329335.3_5'UTR	NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	137					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTGGGGCTTCACGCTGGCCT	0.602000													25	51					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088726	9088726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9088726G>A	ENST00000397910.4	-	1	3292	c.3089C>T	c.(3088-3090)cCa>cTa	p.P1030L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1030	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATAGAGCCTGGGCCATTCGT	0.478000													54	116					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100687	93100687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:93100687G>A	ENST00000544406.2	+	2	546	c.280G>A	c.(280-282)Gat>Aat	p.D94N	C12orf74_ENST00000397833.3_Missense_Mutation_p.D94N			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	94										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						AAGCCCAAAGGATTCTTCACA	0.572000													24	56					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52897398	52897398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52897398G>A	ENST00000261844.7	-	7	2544	c.2392C>T	c.(2392-2394)Cat>Tat	p.H798Y	FAM214A_ENST00000546305.2_Missense_Mutation_p.H805Y	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	798																	TCCAAGGAATGAAAATTATGT	0.333000													52	134					0	0	1	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237284	30237284	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:30237284G>A	ENST00000378988.4	+	2	688	c.587G>A	c.(586-588)tGg>tAg	p.W196*		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	196	MAGE.						protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						CTCAGTTCCTGGGACTTTCCC	0.488000													3	13					0	0	1	0	0
ATG16L1	55054	broad.mit.edu	37	2	234200865	234200865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234200865C>T	ENST00000392017.4	+	15	1779	c.1522C>T	c.(1522-1524)Cgt>Tgt	p.R508C	ATG16L1_ENST00000392018.1_Missense_Mutation_p.R525C|ATG16L1_ENST00000347464.5_Missense_Mutation_p.R345C|ATG16L1_ENST00000392020.4_Missense_Mutation_p.R489C|ATG16L1_ENST00000373525.5_Missense_Mutation_p.R329C	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	508					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GAGCTGCTCCCGTGATGACTT	0.478000													17	60					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151771802	151771802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:151771802C>T	ENST00000255262.3	-	4	1363	c.1198G>A	c.(1198-1200)Gaa>Aaa	p.E400K		NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	400					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GACATCTGTTCACTAGAGAGG	0.458000													43	107					0	0	1	0	0
TBC1D5	9779	broad.mit.edu	37	3	17208398	17208398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:17208398G>A	ENST00000253692.7	-	21	3619	c.1955C>T	c.(1954-1956)tCc>tTc	p.S652F	TBC1D5_ENST00000446818.2_Missense_Mutation_p.S674F|TBC1D5_ENST00000429383.4_Missense_Mutation_p.S652F|TBC1D5_ENST00000414318.2_5'UTR	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	652						intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						AAAACGCAGGGAACCTTTTAG	0.448000													18	37					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102183090	102183090	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:102183090C>T	ENST00000306176.1	+	7	904	c.804C>T	c.(802-804)ttC>ttT	p.F268F	ZPLD1_ENST00000466937.1_Silent_p.F252F|ZPLD1_ENST00000491959.1_Silent_p.F252F	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	252	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						ATGATCTTTTCCTTAGGTAAG	0.313000													35	90					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127685093	127685093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127685093G>A	ENST00000508053.1	-	29	3909	c.2935C>T	c.(2935-2937)Cat>Tat	p.H979Y	FBN2_ENST00000262464.4_Missense_Mutation_p.H979Y|FBN2_ENST00000508989.1_Missense_Mutation_p.H946Y			P35556	FBN2_HUMAN	fibrillin 2	979	EGF-like 14; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CACTCGCAATGAAAAGATCCC	0.478000													22	37					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3508653	3508653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3508653C>T	ENST00000315677.3	-	11	3081	c.2486G>A	c.(2485-2487)gGa>gAa	p.G829E	DLGAP1_ENST00000539435.1_Missense_Mutation_p.G537E|DLGAP1_ENST00000581699.1_Missense_Mutation_p.G535E|DLGAP1_ENST00000400149.3_Missense_Mutation_p.G519E|DLGAP1_ENST00000400155.1_Missense_Mutation_p.G535E|DLGAP1_ENST00000581527.1_Missense_Mutation_p.G829E|DLGAP1_ENST00000515196.2_Missense_Mutation_p.G829E|DLGAP1_ENST00000400147.2_Missense_Mutation_p.G527E|DLGAP1_ENST00000584874.1_Missense_Mutation_p.G829E|DLGAP1_ENST00000400150.3_Missense_Mutation_p.G545E|DLGAP1_ENST00000534970.1_Missense_Mutation_p.G513E|DLGAP1_ENST00000400145.2_Missense_Mutation_p.G527E	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	829					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				TCGGATTTTTCCTAGAACTGG	0.413000													12	23					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725545	140725545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140725545C>T	ENST00000253812.6	+	1	1945	c.1945C>T	c.(1945-1947)Cac>Tac	p.H649Y	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTCCAGGACCACGGCCAGCC	0.711000													26	112					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394679	164394679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164394679C>T	ENST00000280605.3	-	1	368	c.208G>A	c.(208-210)Gac>Aac	p.D70N		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	70						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ATGAACCGGTCGTTGTCCGGG	0.552000													9	31					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72498746	72498746	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72498746C>T	ENST00000373208.1	+	11	1757	c.1757_splice	c.e11+1	p.S586_splice	ADAMTS14_ENST00000373207.1_Splice_Site_p.S583_splice	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	583	TSP type-1 1.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						AACAACCCCTCGTGAGTGTGC	0.672000													13	24					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327635	16327635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:16327635G>A	ENST00000244769.4	-	8	1843	c.907C>T	c.(907-909)Cgg>Tgg	p.R303W	ATXN1_ENST00000436367.1_Missense_Mutation_p.R303W	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	303					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association	p.R303W(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GTGGCCTCCCGAGGGACAAAG	0.662000													25	43					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52284496	52284496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:52284496C>T	ENST00000356297.4	-	19	3938	c.3838G>A	c.(3838-3840)Gat>Aat	p.D1280N	PXDNL_ENST00000543296.1_Missense_Mutation_p.D1280N	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1280					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTCAGGTAATCCTGTGGGTAT	0.522000													7	23					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57333046	57333046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57333046G>A	ENST00000326441.9	-	7	1005	c.642C>T	c.(640-642)gaC>gaT	p.D214D	ZIM2_ENST00000221722.5_Silent_p.D89D|ZIM2_ENST00000601070.1_Silent_p.D89D|ZIM2_ENST00000599935.1_Silent_p.D89D|PEG3_ENST00000598410.1_Silent_p.D89D|PEG3_ENST00000593695.1_Silent_p.D88D|ZIM2_ENST00000593711.1_Silent_p.D89D|ZIM2_ENST00000391708.3_Silent_p.D89D|PEG3_ENST00000423103.2_Silent_p.D214D	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	214					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AAGCCCTGGAGTCCCTGTCGT	0.507000													64	148					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617473	77617473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77617473G>A	ENST00000521891.2	+	2	1598	c.1150G>A	c.(1150-1152)Gga>Aga	p.G384R	ZFHX4_ENST00000455469.2_Missense_Mutation_p.G384R|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G384R|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G384R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	384						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTTCTTAAAAGGAAGCGCGAG	0.517000										HNSCC(33;0.089)			15	53					0	0	1	0	0
ACTA1	58	broad.mit.edu	37	1	229568554	229568554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:229568554G>A	ENST00000366684.3	-	3	305	c.203C>T	c.(202-204)aCc>aTc	p.T68I	ACTA1_ENST00000366683.2_Missense_Mutation_p.T68I	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	68			T -> I (in NEM3).		muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GTACTTCAGGGTCAGGATACC	0.582000													31	79					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96213026	96213026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:96213026C>T	ENST00000324765.8	+	16	2161	c.1814C>T	c.(1813-1815)cCa>cTa	p.P605L	DIAPH2_ENST00000373061.3_Missense_Mutation_p.P605L|DIAPH2_ENST00000373049.4_Missense_Mutation_p.P605L|DIAPH2_ENST00000355827.4_Missense_Mutation_p.P605L|DIAPH2_ENST00000373054.4_Missense_Mutation_p.P601L			O60879	DIAP2_HUMAN	diaphanous-related formin 2	605	FH1.|Poly-Pro.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						GGACCTCCTCCACCACCACCC	0.517000													21	16					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109840226	109840226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109840226G>A	ENST00000357155.1	-	3	297	c.248C>T	c.(247-249)cCt>cTt	p.P83L	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	83	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		GATGGCTTGAGGTTTGGGCTT	0.587000													16	36					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6488466	6488466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6488466G>A	ENST00000377828.1	+	2	643	c.475G>A	c.(475-477)Gag>Aag	p.E159K		NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	159					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		GCTTCTCGTCGAGCACTACCC	0.642000													23	51					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41444953	41444953	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41444953C>T	ENST00000599198.1	+	0	618					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						GAAAACGCTTCCACTACCAAG	0.507000													15	31					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185851	127185851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:127185851G>A	ENST00000371124.3	-	1	531	c.335C>T	c.(334-336)tCt>tTt	p.S112F		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	112						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						AGGATTCAAAGAGGGCTCGGT	0.483000													133	98					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871400	51871400	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51871400G>A	ENST00000371497.5	+	2	2290	c.1403G>A	c.(1402-1404)aGg>aAg	p.R468K	TSHZ2_ENST00000603338.2_Missense_Mutation_p.R465K|TSHZ2_ENST00000329613.6_Missense_Mutation_p.R465K	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	468					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AAAAAAGAAAGGCCAGAGGAA	0.423000													32	130					0	0	1	0	0
RASA3	22821	broad.mit.edu	37	13	114773083	114773083	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:114773083C>T	ENST00000334062.7	-	18	1790		c.e18-1		RASA3_ENST00000389544.4_Splice_Site	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3						intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity	p.?(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			GATCCAAGAACTAAAGTTGGA	0.532000													4	47					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54420801	54420801	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54420801G>A	ENST00000474759.1	+	4	429	c.381_splice	c.e4+1	p.Q127_splice	CACNA2D3_ENST00000490478.1_Splice_Site_p.Q33_splice|CACNA2D3_ENST00000288197.5_Splice_Site_p.Q127_splice|CACNA2D3_ENST00000415676.2_Splice_Site_p.Q127_splice	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	127						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CAGACTTACAGGTAACTGATT	0.383000													5	15					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216497518	216497518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216497518C>T	ENST00000366943.2	-	7	1706	c.1320G>A	c.(1318-1320)caG>caA	p.Q440Q	USH2A_ENST00000366942.3_Silent_p.Q440Q|USH2A_ENST00000307340.3_Silent_p.Q440Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	440	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACTTGGAAAGCTGAAGACAGT	0.358000										HNSCC(13;0.011)			12	33					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159499093	159499093	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:159499093C>T	ENST00000389757.3	+	11	1916	c.1791C>T	c.(1789-1791)ctC>ctT	p.L597L	PKP4_ENST00000389759.3_Silent_p.L597L	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	597					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						TTCGAAACCTCGTTTTTGGCA	0.433000										HNSCC(62;0.18)			25	106					0	0	1	0	0
NAA60	79903	broad.mit.edu	37	16	3533403	3533403	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3533403C>T	ENST00000407558.4	+	6	681	c.378C>T	c.(376-378)acC>acT	p.T126T	NAA60_ENST00000570551.1_3'UTR|NAA60_ENST00000572584.1_Silent_p.T126T|NAA60_ENST00000424546.2_Silent_p.T133T|NAA60_ENST00000575076.1_Silent_p.T126T|NAA60_ENST00000421765.3_Intron|NAA60_ENST00000360862.5_Silent_p.T61T|NAA60_ENST00000414063.2_Silent_p.T126T|NAA60_ENST00000573580.1_Silent_p.T61T|NAA60_ENST00000577013.1_Intron|NAA60_ENST00000570819.1_Intron|LA16c-306E5.2_ENST00000575785.1_RNA|NAA60_ENST00000572942.1_Intron|LA16c-306E5.3_ENST00000574423.2_RNA|NAA60_ENST00000576916.1_Intron	NM_001083601.1	NP_001077070.1	Q9H7X0	NAT15_HUMAN	N(alpha)-acetyltransferase 60, NatF catalytic subunit	126	N-acetyltransferase.						N-acetyltransferase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)	7						ACATATCAACCACCGCCCAGG	0.468000													8	18					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59211264	59211264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59211264C>T	ENST00000302030.2	+	1	648	c.623C>T	c.(622-624)aCt>aTt	p.T208I		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						GTGGTGGTCACTGTCGGAGGA	0.527000													47	144					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596407	24596407	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24596407C>T	ENST00000535378.1	-	4	1110	c.468G>A	c.(466-468)aaG>aaA	p.K156K	KIAA0319_ENST00000543707.1_Silent_p.K165K|KIAA0319_ENST00000430948.2_Silent_p.K120K|KIAA0319_ENST00000378214.3_Silent_p.K165K|KIAA0319_ENST00000537886.1_Silent_p.K165K	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	165					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GCAAGAGGTCCTTCTCCAGCT	0.577000													22	52					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134920413	134920413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134920413G>A	ENST00000398015.3	+	12	2598	c.2228G>A	c.(2227-2229)cGg>cAg	p.R743Q	EPHB1_ENST00000493838.1_Missense_Mutation_p.R304Q	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	743	Protein kinase.		R -> Q (in a gastric adenocarcinoma sample; somatic mutation).			integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.R743Q(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TATGTGCATCGGGACCTGGCT	0.552000													33	183					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394440	164394440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164394440C>T	ENST00000280605.3	-	1	607	c.447G>A	c.(445-447)cgG>cgA	p.R149R		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	149						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GGCAGAACACCCGGTAGCTGG	0.532000													19	86					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092793	151092793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151092793G>A	ENST00000370340.3	+	3	924	c.657G>A	c.(655-657)gaG>gaA	p.E219E	MAGEA4_ENST00000393920.1_Silent_p.E219E|MAGEA4_ENST00000393921.1_Silent_p.E219E|MAGEA4_ENST00000370337.4_Silent_p.E219E|MAGEA4_ENST00000276344.2_Silent_p.E219E|MAGEA4_ENST00000360243.2_Silent_p.E219E|MAGEA4_ENST00000370335.1_Silent_p.E219E			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	219	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GCGCCTCTGAGGAGGAAATCT	0.552000													57	53					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33495271	33495271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33495271C>T	ENST00000268876.5	+	10	1440	c.1343C>T	c.(1342-1344)gCc>gTc	p.A448V	UNC45B_ENST00000433649.1_Missense_Mutation_p.A448V|UNC45B_ENST00000591048.1_Missense_Mutation_p.A448V|UNC45B_ENST00000378449.1_Missense_Mutation_p.A448V|UNC45B_ENST00000394570.2_Missense_Mutation_p.A448V	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	448					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				CTCATCCATGCCTCCACGAAG	0.557000													22	18					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56392911	56392911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56392911C>T	ENST00000301295.6	+	10	3365	c.2943C>T	c.(2941-2943)acC>acT	p.T981T	NLRP4_ENST00000587891.1_Silent_p.T906T|NLRP4_ENST00000346986.5_Silent_p.T925T	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	981							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTAACCTGACCATCACAGACG	0.478000													18	40					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141765557	141765557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141765557G>A	ENST00000475668.2	+	40	4750	c.4696G>A	c.(4696-4698)Gag>Aag	p.E1566K	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1566	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CGCTGAGTACGAGATGTGTGT	0.498000													18	40					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256942	16256942	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16256942C>T	ENST00000375759.3	+	11	4411	c.4207C>T	c.(4207-4209)Cga>Tga	p.R1403*		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1403					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGAAAGTTCTCGATTGTCTTT	0.418000													35	65					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32138307	32138307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32138307C>T	ENST00000312561.4	+	4	4832	c.4418C>T	c.(4417-4419)cCa>cTa	p.P1473L	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		AAAAACGTGCCATGTGATTCT	0.398000													36	80					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070233	141070233	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:141070233G>A	ENST00000503395.1	+	0	1313																											AACGCTCCAAGGTCATCCTGT	0.607000													5	18					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11944573	11944573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11944573C>T	ENST00000256720.2	+	15	2023	c.1930C>T	c.(1930-1932)Ccc>Tcc	p.P644S	LPIN1_ENST00000449576.2_Missense_Mutation_p.P729S|LPIN1_ENST00000396099.1_Missense_Mutation_p.P686S|LPIN1_ENST00000425416.2_Missense_Mutation_p.P650S|LPIN1_ENST00000396097.1_Missense_Mutation_p.P374S|LPIN1_ENST00000404113.2_Missense_Mutation_p.P145S	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	644	C-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		GAAGAATGGCCCCAACGACGT	0.468000													21	66					0	0	1	0	0
TRBV5-6	28609	broad.mit.edu	37	7	142131446	142131446	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142131446C>T	ENST00000390375.2	-	0	349																											GGGCCGAGTCCCCCAGCAACA	0.517000													37	81					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23318846	23318846	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23318846G>A	ENST00000593635.1	+	3	402	c.131G>A	c.(130-132)gGt>gAt	p.G44D	ZNF730_ENST00000597761.2_Splice_Site					zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						AAACCCCCAGGTAGGTGACAG	0.363000													30	100					0	0	1	0	0
SSTR1	6751	broad.mit.edu	37	14	38679711	38679711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:38679711C>T	ENST00000267377.2	+	3	1734	c.1117C>T	c.(1117-1119)Ctg>Ttg	p.L373L		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	373					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	ACCTGAGAACCTGGAGTCCGG	0.662000													15	77					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21042517	21042517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21042517C>T	ENST00000261383.3	-	37	5288	c.5289G>A	c.(5287-5289)gtG>gtA	p.V1763V	DNAH3_ENST00000415178.1_Silent_p.V1763V	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1763	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACTCGTGGCTCACTTGGTCAA	0.522000													21	67					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65263415	65263415	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65263415C>T	ENST00000389722.3	-	10	1254	c.1201G>A	c.(1201-1203)Gaa>Aaa	p.E401K	SPTB_ENST00000556626.1_Missense_Mutation_p.E401K|SPTB_ENST00000542895.1_Missense_Mutation_p.E401K|SPTB_ENST00000389721.5_Missense_Mutation_p.E401K|SPTB_ENST00000389720.3_Missense_Mutation_p.E401K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	401					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TACTCAGCTTCCTCCAGGCTT	0.577000													12	47					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25457027	25457027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:25457027G>A	ENST00000278886.6	-	17	2973	c.2900C>T	c.(2899-2901)tCg>tTg	p.S967L	NINL_ENST00000422516.1_Intron	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	967					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding	p.S967L(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						TCCCCTGCACGAAGCGGCCGG	0.687000													10	56					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120369297	120369297	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120369297G>A	ENST00000602047.1	+	14	1544	c.432G>A	c.(430-432)cgG>cgA	p.R144R	PCDP1_ENST00000413369.3_Silent_p.R430R|PCDP1_ENST00000597189.1_3'UTR			Q4G0U5	PCDP1_HUMAN		430						cilium	calmodulin binding					Colorectal(110;0.196)					GCCATAAACGGGTTGTTCGCA	0.328000													13	71					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186338624	186338624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186338624C>T	ENST00000411641.2	+	7	1228	c.1009C>T	c.(1009-1011)Cgg>Tgg	p.R337W	AHSG_ENST00000273784.5_Missense_Mutation_p.R338W			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	337					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GTCGCACCCCCGGAAAACACG	0.607000													26	82					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199453	4199453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:4199453G>A	ENST00000296358.4	-	5	1132	c.1108C>T	c.(1108-1110)Cgg>Tgg	p.R370W		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	370					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTGTAAATCCGGATTCCAGCC	0.582000													31	68					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70349006	70349006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70349006G>A	ENST00000338508.4	-	24	2094	c.2095C>T	c.(2095-2097)Cac>Tac	p.H699Y	SHANK2_ENST00000357171.3_Missense_Mutation_p.H110Y|SHANK2_ENST00000449116.2_Missense_Mutation_p.H110Y|SHANK2_ENST00000423696.2_Missense_Mutation_p.H319Y|SHANK2_ENST00000409161.1_Missense_Mutation_p.H109Y|SHANK2_ENST00000409530.1_Missense_Mutation_p.H109Y|SHANK2_ENST00000449833.2_Missense_Mutation_p.H110Y			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	319					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACCTGCCTGTGGCCGACTTTG	0.577000													22	74					0	0	1	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145473840	145473840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145473840C>T	ENST00000323397.4	+	4	1805	c.512C>T	c.(511-513)cCt>cTt	p.P171L		NM_001039888.2	NP_001034977.1	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34A	171										endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	20	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GTGGAGGACCCTGCTCCCGCC	0.627000													15	80					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155792079	155792079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155792079G>A	ENST00000437809.1	-	4	1008	c.886C>T	c.(886-888)Cat>Tat	p.H296Y	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Missense_Mutation_p.H296Y|GON4L_ENST00000368331.1_Missense_Mutation_p.H296Y|GON4L_ENST00000271883.5_Missense_Mutation_p.H296Y			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	296					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTACTCACATGAAGGATGTTT	0.418000													49	100					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73040873	73040873	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73040873G>A	ENST00000604411.1	+	0	28834				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AACTGTGAAAGGAAGGCTTTT	0.373000													10	20					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14806731	14806731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14806731G>A	ENST00000380881.4	-	19	4020	c.3205C>T	c.(3205-3207)Cct>Tct	p.P1069S	FREM1_ENST00000380880.3_Missense_Mutation_p.P1068S|FREM1_ENST00000422223.2_Missense_Mutation_p.P1068S			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1068					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCAAACTGAGGAGGAGAAACC	0.448000													3	14					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32977057	32977057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32977057C>T	ENST00000340811.4	-	7	1704	c.1596G>A	c.(1594-1596)atG>atA	p.M532I	PKP2_ENST00000070846.6_Missense_Mutation_p.M576I	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	576					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CACATCTTCTCATCGCTTTTC	0.408000													31	66					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173883916	173883916	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173883916C>T	ENST00000367698.3	-	2	301	c.183G>A	c.(181-183)aaG>aaA	p.K61K	SERPINC1_ENST00000494024.1_5'UTR	NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	61					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	CCTCAGTTGCCTTCTTCTCCG	0.582000											OREG0013990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	166					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24873522	24873522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24873522G>A	ENST00000396432.2	-	26	6182	c.5696C>T	c.(5695-5697)tCt>tTt	p.S1899F		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1898					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GGTGCTGGAAGAACTGCCTGT	0.493000													47	107					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46326873	46326873	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46326873C>T	ENST00000397850.2	-	5	737	c.285G>A	c.(283-285)caG>caA	p.Q95Q	ITGB2_ENST00000397854.3_Silent_p.Q95Q|ITGB2_ENST00000397857.1_Silent_p.Q95Q|ITGB2_ENST00000302347.5_Silent_p.Q95Q|ITGB2_ENST00000397852.1_Silent_p.Q95Q|ITGB2_ENST00000355153.4_Silent_p.Q95Q			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	95					apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	ACAGCTGCTTCTGGCCCCCAT	0.617000													28	69					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101767275	101767275	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101767275C>T	ENST00000375001.3	+	9	1719	c.1296C>T	c.(1294-1296)gcC>gcT	p.A432A		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	432	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GTGGTGTGGCCCCCGGGGAGC	0.622000													15	64					0	0	1	0	0
PTPDC1	138639	broad.mit.edu	37	9	96860798	96860798	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96860798C>T	ENST00000375360.3	+	7	2128	c.1788C>T	c.(1786-1788)gcC>gcT	p.A596A	PTPDC1_ENST00000288976.3_Silent_p.A648A	NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	596							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						CGGCCAAAGCCCTAGCAAATT	0.388000													43	82					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175137	143175137	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143175137C>T	ENST00000408916.1	+	1	172	c.172C>T	c.(172-174)Ctg>Ttg	p.L58L	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	58					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					CCGCTTCTGCCTGCAGTTGGT	0.567000													22	104					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165349587	165349587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165349587G>A	ENST00000263915.3	-	14	2120	c.1582C>T	c.(1582-1584)Cct>Tct	p.P528S	GRB14_ENST00000497306.1_5'UTR|GRB14_ENST00000543549.1_Missense_Mutation_p.P441S	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	528	SH2.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						AACTTGCAAGGAAGAACGCCC	0.383000													16	62					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186338623	186338623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186338623C>T	ENST00000411641.2	+	7	1227	c.1008C>T	c.(1006-1008)ccC>ccT	p.P336P	AHSG_ENST00000273784.5_Silent_p.P337P			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	336					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		TGTCGCACCCCCGGAAAACAC	0.607000													28	86					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48752648	48752648	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:48752648G>A	ENST00000314191.2	-	56	7436	c.7380C>T	c.(7378-7380)ttC>ttT	p.F2460F	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Silent_p.F2460F	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2461	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GATGGGAAACGAATTCCACAA	0.333000								Non-homologous end-joining					3	8					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119053962	119053962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119053962C>T	ENST00000409109.1	+	10	3329	c.2742C>T	c.(2740-2742)ctC>ctT	p.L914L	NLRX1_ENST00000409991.1_Silent_p.L914L|NLRX1_ENST00000409265.4_Intron|NLRX1_ENST00000292199.2_Silent_p.L914L|NLRX1_ENST00000469103.2_3'UTR|NLRX1_ENST00000525863.1_Intron			Q86UT6	NLRX1_HUMAN	NLR family member X1	914	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CAGTGATCCTCAGTGAAGTCC	0.617000													9	74					0	0	1	0	0
FAS	355	broad.mit.edu	37	10	90770529	90770529	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90770529G>A	ENST00000355740.2	+	6	745	c.525G>A	c.(523-525)ggG>ggA	p.G175G	FAS_ENST00000357339.2_Intron|FAS_ENST00000352159.4_Silent_p.G175G|FAS_ENST00000313771.5_3'UTR|FAS_ENST00000355279.2_Silent_p.G175G	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	175					activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		CTAACTTGGGGTGGCTTTGTC	0.348000													69	306					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141894	29141894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29141894C>T	ENST00000377167.2	+	1	584	c.482C>T	c.(481-483)tCc>tTc	p.S161F		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						GCACTTCATTCCTCCTTTACT	0.463000													92	203					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683513	159683513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159683513G>A	ENST00000255030.5	-	2	580	c.477C>T	c.(475-477)tcC>tcT	p.S159S	CRP_ENST00000368110.1_Intron|CRP_ENST00000473196.1_5'UTR|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000437342.1_5'UTR|CRP_ENST00000368111.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	159	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	TCCCACCGAAGGAATCCTGCT	0.517000													126	335					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88472476	88472476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88472476C>T	ENST00000394480.1	-	17	2400	c.2079G>A	c.(2077-2079)gtG>gtA	p.V693V	NTRK3_ENST00000542733.2_Silent_p.V595V|NTRK3_ENST00000355254.2_Silent_p.V693V|NTRK3_ENST00000357724.2_Silent_p.V685V|NTRK3_ENST00000558676.1_Silent_p.V685V|NTRK3_ENST00000360948.2_Silent_p.V693V|NTRK3_ENST00000557856.1_Silent_p.V685V	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	693	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCCCAATCTTCACTAGCAGAT	0.562000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			12	160					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45839446	45839446	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45839446A>C	ENST00000311275.7	-	22	3774	c.3521T>G	c.(3520-3522)cTc>cGc	p.L1174R	ZMYND8_ENST00000540497.1_Missense_Mutation_p.L1122R|ZMYND8_ENST00000262975.4_Missense_Mutation_p.L1156R|ZMYND8_ENST00000352431.2_Missense_Mutation_p.L1148R|ZMYND8_ENST00000458360.2_Missense_Mutation_p.L1042R|ZMYND8_ENST00000355972.4_Missense_Mutation_p.L1202R|ZMYND8_ENST00000536340.1_Missense_Mutation_p.L1229R|ZMYND8_ENST00000372023.3_Missense_Mutation_p.L1124R|ZMYND8_ENST00000360911.3_Missense_Mutation_p.L1123R|ZMYND8_ENST00000471951.2_Missense_Mutation_p.L1222R|ZMYND8_ENST00000396281.4_Missense_Mutation_p.L1174R|ZMYND8_ENST00000446994.2_Missense_Mutation_p.L1093R|ZMYND8_ENST00000461685.1_Missense_Mutation_p.L1176R			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	1174	Interacts with PRKCB1.						protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TTTCGGGAGGAGGCTCTTCGT	0.537000													21	108					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60773266	60773266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:60773266G>A	ENST00000335712.6	-	2	452	c.225C>T	c.(223-225)ctC>ctT	p.L75L	BCL11A_ENST00000538214.1_Silent_p.L75L|BCL11A_ENST00000359629.5_Silent_p.L75L|BCL11A_ENST00000356842.4_Silent_p.L75L|BCL11A_ENST00000537768.1_5'UTR|BCL11A_ENST00000358510.4_Silent_p.L75L	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	75	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TTTCTAAGCAGAGGCTGCCAT	0.498000			T	IGH@	B-CLL								11	88					0	0	1	0	0
AQP12A	375318	broad.mit.edu	37	2	241631526	241631526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241631526G>A	ENST00000429564.1	+	2	258	c.195G>A	c.(193-195)ggG>ggA	p.G65G	AQP12A_ENST00000337801.4_Silent_p.G53G			Q8IXF9	AQ12A_HUMAN	aquaporin 12A	53						integral to membrane	transporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(7)	14		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		CCTGGGCTGGGGACTTTGGGC	0.697000													6	27					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100645220	100645220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100645220C>T	ENST00000471714.1	-	2	315	c.206G>A	c.(205-207)gGa>gAa	p.G69E	ABI3BP_ENST00000532144.1_5'UTR|ABI3BP_ENST00000495063.1_Missense_Mutation_p.G69E|ABI3BP_ENST00000284322.5_Missense_Mutation_p.G69E			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	69						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GCTGCCATATCCCAGGAGAAG	0.473000													14	70					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10293918	10293918	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10293918C>T	ENST00000403437.2	-	40	5761	c.5667G>A	c.(5665-5667)gaG>gaA	p.E1889E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1889					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TGGATTGTTCCTCCTAAGAAT	0.428000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				38	53					0	0	1	0	0
FAM65B	9750	broad.mit.edu	37	6	24865551	24865551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24865551C>T	ENST00000259698.4	-	7	717	c.542G>A	c.(541-543)cGg>cAg	p.R181Q	FAM65B_ENST00000538035.1_Missense_Mutation_p.R210Q|FAM65B_ENST00000510784.2_Missense_Mutation_p.R215Q|FAM65B_ENST00000378023.4_Missense_Mutation_p.R181Q|FAM65B_ENST00000540914.1_Missense_Mutation_p.R181Q	NM_014722.2	NP_055537.2	Q9Y4F9	FA65B_HUMAN	family with sequence similarity 65, member B	181					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	25						CTTGAAGCTCCGATTGATCTC	0.522000													28	59					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508120	37508120	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37508120G>A	ENST00000374660.1	+	40	3768	c.3669G>A	c.(3667-3669)agG>agA	p.R1223R	ANKRD30A_ENST00000361713.1_Silent_p.R1104R|ANKRD30A_ENST00000602533.1_Silent_p.R1104R			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1170						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TAACTAAAAGGGCATCTCAAT	0.333000													51	183					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538663	4538663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4538663G>A	ENST00000306390.6	-	2	793	c.333C>T	c.(331-333)ttC>ttT	p.F111F	LRG1_ENST00000586883.1_5'UTR|CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	111						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGCCGCAGGAATTCGGGCG	0.652000													13	43					0	0	1	0	0
ATP6V1C2	245973	broad.mit.edu	37	2	10911968	10911968	+	Silent	SNP	G	G	A	rs142569799	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:10911968G>A	ENST00000381661.3	+	7	583	c.474G>A	c.(472-474)ggG>ggA	p.G158G	ATP6V1C2_ENST00000272238.4_Silent_p.G158G	NM_144583.3	NP_653184.2	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	158					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		CTTTTAGGGGGAACCTCTTCA	0.537000													63	128					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794955	126794955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126794955C>T	ENST00000373615.4	+	5	1929	c.1190C>T	c.(1189-1191)cCc>cTc	p.P397L		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	397				GHEPHSPSQTTLTNLF -> AMSLTAPHKRLLPTFSNDSQP PHPTISLKKKLSLV (in Ref. 1; AAB08752).		nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						CCTCACAGCCCCTCACAAACG	0.488000													24	62					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003639	57003639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57003639G>A	ENST00000606794.1	-	1	1036	c.840C>T	c.(838-840)ccC>ccT	p.P280P		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	280						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						CAAAGTCACAGGGCCAGTGCA	0.562000													12	32					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55512153	55512153	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55512153G>A	ENST00000543010.1	+	13	3219	c.3076G>A	c.(3076-3078)Gaa>Aaa	p.E1026K	NLRP2_ENST00000339757.7_Missense_Mutation_p.E1004K|NLRP2_ENST00000391721.4_Missense_Mutation_p.E1002K|NLRP2_ENST00000427260.2_Missense_Mutation_p.E1003K|NLRP2_ENST00000538819.1_Missense_Mutation_p.E1002K|NLRP2_ENST00000263437.6_Missense_Mutation_p.E1023K|NLRP2_ENST00000537859.1_Missense_Mutation_p.E1004K|NLRP2_ENST00000448584.2_Missense_Mutation_p.E1026K	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	1026					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTTTAATGATGAACTCAATAA	0.388000													42	93					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211179661	211179661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211179661C>T	ENST00000352451.3	-	1	253	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K		NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	36					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		TCAATTTTTTCTTCTTTGGGT	0.512000													86	219					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141052202	141052202	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141052202G>A	ENST00000239440.4	-	9	1367	c.1302C>T	c.(1300-1302)atC>atT	p.I434I	ARAP3_ENST00000513878.1_Silent_p.I96I|ARAP3_ENST00000508305.1_Silent_p.I356I	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	434	PH 2.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CGATGAAGCAGATCCCGATGC	0.642000													19	31					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119737566	119737566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119737566G>A	ENST00000313400.4	-	10	1910	c.1810C>T	c.(1810-1812)Ccg>Tcg	p.P604S	ASTN2_ENST00000361209.2_Missense_Mutation_p.P553S|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.P600S			O75129	ASTN2_HUMAN	astrotactin 2	604						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TCCACAGGCGGAACCACAAAG	0.552000													9	65					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8183561	8183561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:8183561C>T	ENST00000402384.3	-	9	1112	c.846G>A	c.(844-846)gaG>gaA	p.E282E	ICA1_ENST00000422063.2_Silent_p.E282E|ICA1_ENST00000396675.3_Silent_p.E282E|ICA1_ENST00000265577.7_Silent_p.E281E|ICA1_ENST00000401396.1_Silent_p.E270E|ICA1_ENST00000406470.2_Silent_p.E282E			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	282					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TTTTCTTCTTCTCTTCTTTCT	0.408000													22	40					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183717885	183717885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183717885G>A	ENST00000511685.1	+	27	7432	c.7309G>A	c.(7309-7311)Gaa>Aaa	p.E2437K	TENM3_ENST00000406950.2_Missense_Mutation_p.E2437K					teneurin transmembrane protein 3																		ACCTTCTTACGAACTTGTGAA	0.408000													7	20					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140938301	140938301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140938301C>T	ENST00000277549.5	+	21	3507	c.938C>T	c.(937-939)cCc>cTc	p.P313L	CACNA1B_ENST00000371357.1_Missense_Mutation_p.P1122L|CACNA1B_ENST00000371363.1_Missense_Mutation_p.P1121L|CACNA1B_ENST00000545473.1_Missense_Mutation_p.P147L|CACNA1B_ENST00000277551.2_Missense_Mutation_p.P1121L|CACNA1B_ENST00000371355.4_Missense_Mutation_p.P1122L|CACNA1B_ENST00000371372.1_Missense_Mutation_p.P1121L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1121					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGGAGCGGCCCCCGGCCTATC	0.602000													74	158					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50252887	50252887	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50252887C>T	ENST00000420502.1	+	0	522							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	CCTCAGGGGTCGTGGGTGAGC	0.582000													26	74					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103032170	103032170	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103032170G>A	ENST00000306312.3	-	11	1393	c.1132C>T	c.(1132-1134)Ctg>Ttg	p.L378L	SLC26A5_ENST00000393730.1_Silent_p.L378L|SLC26A5_ENST00000432958.2_Silent_p.L378L|SLC26A5_ENST00000393729.1_Silent_p.L341L|SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000339444.6_Silent_p.L378L|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000393727.1_Silent_p.L378L|SLC26A5_ENST00000393735.2_Silent_p.L378L|SLC26A5_ENST00000393723.1_Silent_p.L378L	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	378					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CACAGTCCCAGGGCAATGAGC	0.438000													5	26					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1499956	1499956	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1499956A>T	ENST00000331035.4	+	11	1370	c.1021A>T	c.(1021-1023)Atg>Ttg	p.M341L	IL3RA_ENST00000381469.2_Missense_Mutation_p.M263L	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	341						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CATCCCTCACATGAAAGACCC	0.547000													95	207					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96134618	96134618	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96134618C>T	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		TGCAGCAGTCCATTGACCAAT	0.517000			T	TRA@	T-ALL								33	91					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62647983	62647983	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:62647983C>T	ENST00000337910.5	-	6	1780	c.1443G>A	c.(1441-1443)aaG>aaA	p.K481K	RHOBTB1_ENST00000357917.4_Silent_p.K481K	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	481					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AGAACGTTCCCTTGCTGAGAC	0.473000													15	30					0	0	1	0	0
PF4	5196	broad.mit.edu	37	4	74846987	74846987	+	Silent	SNP	C	C	T	rs4694		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74846987C>T	ENST00000296029.3	-	3	410	c.240G>A	c.(238-240)agG>agA	p.R80R		NM_002619.3	NP_002610.1	P02776	PLF4_HUMAN	platelet factor 4	80					cytokine-mediated signaling pathway|immune response|leukocyte chemotaxis|negative regulation of angiogenesis|negative regulation of apoptosis|negative regulation of cytolysis|negative regulation of megakaryocyte differentiation|negative regulation of MHC class II biosynthetic process|platelet activation|platelet degranulation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of tumor necrosis factor production	extracellular space|platelet alpha granule lumen	chemokine activity|heparin binding			kidney(1)|lung(1)	2	Breast(15;0.00136)		all cancers(17;0.0034)|Lung(101;0.196)		Drotrecogin alfa(DB00055)	AGCAAATTTTCCTTCCATTCT	0.458000													20	55					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9934828	9934828	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9934828T>A	ENST00000396573.2	-	7	1771	c.1462A>T	c.(1462-1464)Aaa>Taa	p.K488*	GRIN2A_ENST00000535259.1_Nonsense_Mutation_p.K331*|GRIN2A_ENST00000404927.2_Nonsense_Mutation_p.K488*|GRIN2A_ENST00000562109.1_Nonsense_Mutation_p.K488*|GRIN2A_ENST00000330684.3_Nonsense_Mutation_p.K488*|GRIN2A_ENST00000396575.2_Nonsense_Mutation_p.K488*	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	488					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGTTAACTTTCTTGCCATGC	0.438000													57	116					0	0	1	0	0
PIF1	80119	broad.mit.edu	37	15	65108826	65108826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65108826G>A	ENST00000268043.4	-	12	1907	c.1813C>T	c.(1813-1815)Ccc>Tcc	p.P605S	PIF1_ENST00000333425.6_Missense_Mutation_p.P605S|PIF1_ENST00000559239.1_Missense_Mutation_p.P605S			Q9H611	PIF1_HUMAN	PIF1 5'-to-3' DNA helicase	605	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						AGCACACGGGGGTCACAGCGA	0.657000													45	160					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249996	52249996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52249996C>T	ENST00000595042.1	-	3	393	c.252G>A	c.(250-252)agG>agA	p.R84R	FPR1_ENST00000304748.4_Silent_p.R84R	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	84					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CCATGGCCTTCCTGACCATGA	0.517000													24	85					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541538	55541538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55541538G>A	ENST00000361760.1	+	1	625	c.625G>A	c.(625-627)Gag>Aag	p.E209K		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				CATATTCAATGAGGTGAGCAG	0.393000													31	143					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158607824	158607824	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158607824C>T	ENST00000368148.3	-	36	5368	c.5189_splice	c.e36+1	p.E1730_splice	SPTA1_ENST00000368147.3_Splice_Site_p.E1730_splice	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1730					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGCACATACTCTATCCAGGAT	0.403000													35	111					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56416316	56416316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56416316C>T	ENST00000588751.1	-	8	2634	c.2610G>A	c.(2608-2610)gaG>gaA	p.E870E	NLRP13_ENST00000342929.3_Silent_p.E870E			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	870							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ACTCCAGTCTCTCTAAGGCAC	0.413000													21	39					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102508054	102508054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102508054C>T	ENST00000360184.4	+	65	12249	c.12085C>T	c.(12085-12087)Cac>Tac	p.H4029Y	RP11-1017G21.4_ENST00000557551.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4029	AAA 6 (By similarity).		H -> Q (in dbSNP:rs10129889).		cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CGACCTGACCCACATTGTGGG	0.597000													10	89					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121106698	121106698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:121106698C>T	ENST00000295228.3	+	2	518	c.472C>T	c.(472-474)Cgc>Tgc	p.R158C		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	158					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				CTCCCGGGTCCGCCTATACTT	0.557000													31	66					0	0	1	0	0
TNFSF11	8600	broad.mit.edu	37	13	43181040	43181040	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43181040C>T	ENST00000398795.2	+	5	1089	c.721C>T	c.(721-723)Cga>Tga	p.R241*	TNFSF11_ENST00000544862.1_Nonsense_Mutation_p.R241*|TNFSF11_ENST00000405262.2_Nonsense_Mutation_p.R241*|TNFSF11_ENST00000358545.2_Nonsense_Mutation_p.R241*|TNFSF11_ENST00000239849.6_Nonsense_Mutation_p.R314*	NM_003701.3	NP_003692.1	O14788	TNF11_HUMAN	tumor necrosis factor (ligand) superfamily, member 11	314					immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding			kidney(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	10		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TTTTAAAGTTCGAGATATAGA	0.408000													31	74					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200967678	200967678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200967678G>A	ENST00000332129.2	-	14	2227	c.1911C>T	c.(1909-1911)gcC>gcT	p.A637A	KIF21B_ENST00000360529.5_Silent_p.A637A|KIF21B_ENST00000461742.2_Silent_p.A637A|KIF21B_ENST00000422435.2_Silent_p.A637A	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	637					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						AAGTCAGGTCGGCCAGGTCCG	0.587000													28	63					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111426819	111426819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111426819G>A	ENST00000393934.3	+	2	780	c.210G>A	c.(208-210)gtG>gtA	p.V70V	PLCXD2_ENST00000477665.1_Silent_p.V70V	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	70	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						AGTCCCCAGTGGGGCCTGACC	0.493000													9	23					0	0	1	0	0
SPRYD3	84926	broad.mit.edu	37	12	53461987	53461987	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53461987G>A	ENST00000301463.4	-	7	881	c.795C>T	c.(793-795)atC>atT	p.I265I	SPRYD3_ENST00000547837.1_Silent_p.I302I	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	265										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						CAGGGTCCACGATCTCCACCT	0.612000													52	132					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	20734318	20734318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20734318C>T	ENST00000382148.3	-	6	889	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	KCNIP4_ENST00000382152.2_Missense_Mutation_p.E210K|KCNIP4_ENST00000382149.4_5'UTR|KCNIP4_ENST00000509207.1_Missense_Mutation_p.E148K|KCNIP4_ENST00000447367.2_Missense_Mutation_p.E176K|PACRGL_ENST00000507634.1_Intron|KCNIP4_ENST00000359001.5_Missense_Mutation_p.E148K|KCNIP4_ENST00000382150.4_Missense_Mutation_p.E189K	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	210	EF-hand 3.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				AAAAATGTTTCAACGTGTTGT	0.363000													24	47					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7700763	7700763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7700763C>T	ENST00000572933.1	+	52	9455	c.7995C>T	c.(7993-7995)ttC>ttT	p.F2665F	DNAH2_ENST00000389173.2_Silent_p.F2665F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2665					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAGAAGCCTTCATGGGCATCA	0.552000													69	77					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160915040	160915040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160915040G>A	ENST00000368029.3	-	8	925	c.868C>T	c.(868-870)Cgt>Tgt	p.R290C	ITLN2_ENST00000494442.1_5'UTR|RP11-544M22.1_ENST00000356006.3_RNA	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	290					signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCACACTGACGGGGTTTGCCC	0.527000													22	39					0	0	1	0	0
SENP2	59343	broad.mit.edu	37	3	185318607	185318607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185318607C>T	ENST00000296257.5	+	5	653	c.413C>T	c.(412-414)aCc>aTc	p.T138I	SENP2_ENST00000545472.1_Missense_Mutation_p.T128I|SENP2_ENST00000427465.2_5'UTR|SENP2_ENST00000465201.1_3'UTR	NM_021627.2	NP_067640.2	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific peptidase 2	138					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(3)	12	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GTGACAGTTACCCGAGATCAG	0.363000													41	202					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322440	55322440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55322440C>T	ENST00000314644.2	+	1	658	c.658C>T	c.(658-660)Ccc>Tcc	p.P220S		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TTTCCAGCTTCCCTTTTGTGG	0.478000										HNSCC(20;0.049)			10	49					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955839	51955839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51955839G>A	ENST00000321424.3	-	7	1360	c.1294C>T	c.(1294-1296)Ccc>Tcc	p.P432S	SIGLEC8_ENST00000340550.5_Missense_Mutation_p.P339S|SIGLEC8_ENST00000430817.1_Missense_Mutation_p.P323S	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	432					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ACAGCTGGGGGAGGCTTCTTC	0.592000													22	42					0	0	1	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315552	73315552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73315552C>T	ENST00000258098.6	-	3	1434	c.1194G>A	c.(1192-1194)gaG>gaA	p.E398E	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	398					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						CAAGCACTGCCTCTGAGCTGC	0.647000													18	75					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8006979	8006979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:8006979C>T	ENST00000344293.5	+	3	1712	c.1506C>T	c.(1504-1506)ccC>ccT	p.P502P		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	502					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CTCCCACTCCCGAACCTCTCC	0.443000													46	108					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719097	140719097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140719097G>A	ENST00000394576.2	+	1	559	c.559G>A	c.(559-561)Gat>Aat	p.D187N	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGGGAGCTGATGGGAACAA	0.567000													12	108					0	0	1	0	0
AVEN	57099	broad.mit.edu	37	15	34159851	34159851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34159851G>A	ENST00000306730.3	-	5	947	c.818C>T	c.(817-819)tCc>tTc	p.S273F		NM_020371.2	NP_065104.1	Q9NQS1	AVEN_HUMAN	apoptosis, caspase activation inhibitor	273					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	7		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		CTGCAGTGGGGAAGTGGGTTT	0.488000													57	93					0	0	1	0	0
NR4A2	4929	broad.mit.edu	37	2	157186322	157186322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:157186322G>A	ENST00000339562.4	-	3	739	c.377C>T	c.(376-378)tCg>tTg	p.S126L	NR4A2_ENST00000409108.2_Missense_Mutation_p.S126L|NR4A2_ENST00000429376.1_Missense_Mutation_p.S63L|NR4A2_ENST00000539077.1_Missense_Mutation_p.S137L|NR4A2_ENST00000409572.1_Missense_Mutation_p.S126L|NR4A2_ENST00000426264.1_Missense_Mutation_p.S63L	NM_006186.3	NP_006177.1	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	126	Gln-rich.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						CGTCGGGGGCGAGGAGGGCTT	0.622000													50	85					0	0	1	0	0
PAX5	5079	broad.mit.edu	37	9	36846859	36846859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:36846859G>A	ENST00000523241.1	-	7	857	c.848C>T	c.(847-849)tCc>tTc	p.S283F	PAX5_ENST00000520281.1_Intron|PAX5_ENST00000377853.2_Intron|PAX5_ENST00000414447.1_Silent_p.F317F|PAX5_ENST00000523145.1_Intron|PAX5_ENST00000377852.2_Silent_p.F326F|PAX5_ENST00000522003.1_Silent_p.F252F|PAX5_ENST00000377847.2_Intron|PAX5_ENST00000358127.4_Silent_p.F360F|PAX5_ENST00000520154.1_Intron|PAX5_ENST00000446742.1_Silent_p.F260F			Q02548	PAX5_HUMAN	paired box 5	292					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(11)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CCGGGTTGGGGAACCTCCAGG	0.627000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								9	21					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34038258	34038258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:34038258G>A	ENST00000382499.2	-	17	2256	c.2257C>T	c.(2257-2259)Cct>Tct	p.P753S	SYNJ1_ENST00000357345.3_Missense_Mutation_p.P714S|SYNJ1_ENST00000382491.3_Missense_Mutation_p.P709S|SYNJ1_ENST00000322229.7_Missense_Mutation_p.P714S|SYNJ1_ENST00000433931.2_Missense_Mutation_p.P753S	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	714	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						CTTACCATAGGAAAACTCAAT	0.348000													14	44					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117306422	117306422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117306422C>T	ENST00000321322.6	-	27	4995	c.4994G>A	c.(4993-4995)gGg>gAg	p.G1665E	DSCAML1_ENST00000527706.1_Missense_Mutation_p.G1395E	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1605					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CAGTGCCACCCCCAGTGTGGC	0.577000													31	61					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197446823	197446823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197446823C>T	ENST00000367400.3	+	12	4170	c.4035C>T	c.(4033-4035)ttC>ttT	p.F1345F	CRB1_ENST00000544212.1_Silent_p.F826F|CRB1_ENST00000538660.1_Silent_p.F809F|CRB1_ENST00000367399.2_Silent_p.F1233F|CRB1_ENST00000535699.1_Silent_p.F1321F	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1345					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCGACATTTTCACCACTATTG	0.438000													6	51					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468689	56468689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:56468689G>A	ENST00000288221.6	-	2	602	c.347C>T	c.(346-348)tCa>tTa	p.S116L		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	116						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		ATCTGTGTATGAAAGGACATC	0.512000													53	136					0	0	1	0	0
FCER1A	2205	broad.mit.edu	37	1	159273855	159273855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159273855G>A	ENST00000368115.1	+	4	313	c.214G>A	c.(214-216)Gaa>Aaa	p.E72K	FCER1A_ENST00000368114.1_Missense_Mutation_p.E39K	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	72	Ig-like 1.					integral to plasma membrane		p.E72Q(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CAGCCTTTCAGAAGAGACAAA	0.363000													39	94					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172582164	172582164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:172582164C>T	ENST00000534253.2	+	8	716	c.548C>T	c.(547-549)cCa>cTa	p.P183L	DYNC1I2_ENST00000397119.3_Missense_Mutation_p.P183L|DYNC1I2_ENST00000409317.1_Missense_Mutation_p.P177L|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.P183L|DYNC1I2_ENST00000409197.1_Missense_Mutation_p.P157L|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.P157L|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.P177L|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.P175L|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.P157L|DYNC1I2_ENST00000410079.3_Missense_Mutation_p.P175L|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.P183L			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	183					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			GCTCCTAAACCACCTATTGAA	0.254000													7	18					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280446	152280446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152280446G>A	ENST00000368799.1	-	3	6951	c.6916C>T	c.(6916-6918)Cat>Tat	p.H2306Y	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2306	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCTCTGCATGATGAGTGCCT	0.562000									Ichthyosis				155	460					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241976665	241976665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241976665G>A	ENST00000310397.8	+	6	940	c.940G>A	c.(940-942)Gaa>Aaa	p.E314K	SNED1_ENST00000401884.1_Missense_Mutation_p.E314K|SNED1_ENST00000342631.6_Missense_Mutation_p.E314K|AC005237.4_ENST00000458377.1_RNA|SNED1_ENST00000405547.3_Missense_Mutation_p.E314K	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	314	EGF-like 2.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		AGACGTGAACGAATGTGCCTC	0.627000													6	12					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35293219	35293219	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:35293219C>A	ENST00000408931.3	-	1	539	c.13G>T	c.(13-15)Gcg>Tcg	p.A5S		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	5						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						TTGGGGGACGCCGTGAACTCC	0.647000													20	56					0.00047179	0.000472372	1	1	0
CHRNA6	8973	broad.mit.edu	37	8	42612175	42612175	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42612175C>T	ENST00000276410.2	-	4	625	c.270G>A	c.(268-270)tgG>tgA	p.W90*	CHRNA6_ENST00000530869.1_5'UTR|CHRNA6_ENST00000534622.1_Nonsense_Mutation_p.W75*	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	90						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TATAATCATTCCAGATCTAAA	0.423000													6	83					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155630087	155630087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155630087G>A	ENST00000368340.5	-	10	2076	c.1968C>T	c.(1966-1968)gcC>gcT	p.A656A	YY1AP1_ENST00000407221.1_Silent_p.A507A|YY1AP1_ENST00000368339.5_Silent_p.A676A|YY1AP1_ENST00000404643.1_Silent_p.A518A|YY1AP1_ENST00000359205.5_Silent_p.A527A|YY1AP1_ENST00000347088.5_Silent_p.A538A|YY1AP1_ENST00000355499.4_Silent_p.A538A|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000295566.4_Silent_p.A584A|YY1AP1_ENST00000361831.5_Silent_p.A527A|YY1AP1_ENST00000311573.5_Silent_p.A507A|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000368330.2_Silent_p.A538A|YY1AP1_ENST00000535662.1_Silent_p.A384A	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TACAGCGAAAGGCCCTGGCTC	0.537000													55	114					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27746305	27746305	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27746305G>A	ENST00000264717.2	+	19	1940	c.1877G>A	c.(1876-1878)tGa>tAa	p.*626*	GCKR_ENST00000424318.2_Silent_p.*436*	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	0					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					GACGTTCAGTGAACCCATGTT	0.612000													16	45					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40035355	40035355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40035355G>A	ENST00000372857.3	-	5	1442	c.650C>T	c.(649-651)aCc>aTc	p.T217I	PABPC4_ENST00000372862.3_Missense_Mutation_p.T217I|PABPC4_ENST00000372856.3_Missense_Mutation_p.T217I|PABPC4_ENST00000372858.3_Missense_Mutation_p.T217I|RP11-69E11.8_ENST00000415255.1_RNA|PABPC4_ENST00000529216.1_Intron	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	217	RRM 3.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GACACTTAGGGTCTTACCTAT	0.438000													14	159					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5863040	5863040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5863040C>T	ENST00000329322.5	-	1	87	c.88G>A	c.(88-90)Gga>Aga	p.G30R	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Missense_Mutation_p.G34R	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGGGAATCCAATCCAGATG	0.448000													33	84					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554246	135554246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135554246C>T	ENST00000372146.4	+	2	1804	c.1240C>T	c.(1240-1242)Cac>Tac	p.H414Y	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	414					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GCTGAATGTTCACAATTCCCA	0.458000													49	121					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039402	31039402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:31039402C>T	ENST00000355537.3	+	4	3023	c.2876C>T	c.(2875-2877)cCc>cTc	p.P959L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	959					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GAGGAGAAACCCAGTGGCAAG	0.577000													53	151					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476983	20476983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20476983C>T	ENST00000573854.1	+	3	436	c.322C>T	c.(322-324)Cgt>Tgt	p.R108C	ACSM2A_ENST00000417235.2_Missense_Mutation_p.R29C|ACSM2A_ENST00000536134.1_5'UTR|ACSM2A_ENST00000396104.2_Missense_Mutation_p.R108C|ACSM2A_ENST00000219054.6_Missense_Mutation_p.R108C|ACSM2A_ENST00000424070.1_Missense_Mutation_p.R108C|ACSM2A_ENST00000575690.1_Missense_Mutation_p.R108C|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	108					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding	p.R108C(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GCGTGGGGATCGTGTGGCAGT	0.572000													18	40					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133779647	133779647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133779647G>A	ENST00000372338.4	-	7	1432	c.1190C>T	c.(1189-1191)tCa>tTa	p.S397L	FIBCD1_ENST00000253018.4_Intron|FIBCD1_ENST00000448616.1_Missense_Mutation_p.S397L|FIBCD1_ENST00000372337.2_Missense_Mutation_p.S239L	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	397	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GTTGTTCTCTGAATGGTCGCT	0.652000													27	99					0	0	1	0	0
TNRC6C	57690	broad.mit.edu	37	17	76089072	76089072	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76089072C>T	ENST00000335749.4	+	15	4589	c.4020C>T	c.(4018-4020)tcC>tcT	p.S1340S	TNRC6C_ENST00000588847.1_Silent_p.S1340S|TNRC6C_ENST00000588061.1_Silent_p.S1343S|TNRC6C_ENST00000541771.1_Silent_p.S1343S|TNRC6C_ENST00000544502.1_Silent_p.S1340S|TNRC6C_ENST00000301624.4_Silent_p.S1343S	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	1343					gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TTGATGACTCCTATGGCCGGT	0.498000													13	36					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28348673	28348673	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28348673C>T	ENST00000337532.5	-	15	1481		c.e15-1		MPP7_ENST00000445954.2_Splice_Site|MPP7_ENST00000540098.1_Splice_Site|MPP7_ENST00000375719.3_Splice_Site|MPP7_ENST00000375732.1_Splice_Site	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)						establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						CTGGTGGTATCTATGATTTAA	0.338000													23	71					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95108164	95108164	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95108164G>A	ENST00000469935.1	+	0	769					NR_015340.1																						AGACCCAGGGGAAGCTCGGGG	0.592000													44	137					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10689791	10689791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:10689791G>A	ENST00000302079.6	-	45	7019	c.7020C>T	c.(7018-7020)ctC>ctT	p.L2340L	PIEZO2_ENST00000538948.1_Silent_p.L297L|PIEZO2_ENST00000285141.4_Silent_p.L195L|PIEZO2_ENST00000580640.1_Silent_p.L2365L|PIEZO2_ENST00000503781.3_Silent_p.L2340L			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2340						integral to membrane	ion channel activity										AAAAGGGCACGAGGCGAAACC	0.562000													16	53					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31895859	31895859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31895859C>T	ENST00000456570.1	+	2	229	c.174C>T	c.(172-174)tcC>tcT	p.S58S	C2_ENST00000299367.5_Silent_p.S58S|C2_ENST00000452323.2_Intron|C2_ENST00000442278.2_Intron|C2_ENST00000469372.1_Intron|CFB_ENST00000477310.1_Silent_p.S58S|CFB_ENST00000556679.1_Silent_p.S58S|C2_ENST00000418949.2_Silent_p.S58S			P00751	CFAB_HUMAN	complement factor B	69	Sushi 1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TGTACCCATCCCCAGCATCAC	0.637000													8	36					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203708726	203708726	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203708726C>T	ENST00000357681.5	+	21	4485	c.3362C>T	c.(3361-3363)cCc>cTc	p.P1121L	ATP2B4_ENST00000391954.2_3'UTR|ATP2B4_ENST00000367219.3_3'UTR|ATP2B4_ENST00000341360.2_3'UTR|ATP2B4_ENST00000367218.3_3'UTR	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	1157					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATTCAGAAACCCTACAACCAA	0.483000													33	92					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79128395	79128395	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:79128395G>A	ENST00000370747.4	+	8	1205	c.1120G>A	c.(1120-1122)Gaa>Aaa	p.E374K	IFI44_ENST00000495254.1_3'UTR	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	374					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						GCAGCTAGAGGAAGTCCAAAG	0.343000													10	87					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14812856	14812856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14812856G>A	ENST00000380881.4	-	17	3665	c.2850C>T	c.(2848-2850)ttC>ttT	p.F950F	FREM1_ENST00000380880.3_Silent_p.F949F|FREM1_ENST00000422223.2_Silent_p.F949F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	949					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CTCTCTGAGAGAACTGATCCA	0.498000													25	172					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6206765	6206765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6206765C>T	ENST00000262450.3	-	10	1649	c.1550G>A	c.(1549-1551)gGg>gAg	p.G517E	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	517	Chromo 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GTAGGACAGCCCTGCCCACTT	0.652000													10	42					0	0	1	0	0
TRIM11	81559	broad.mit.edu	37	1	228584602	228584602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228584602G>A	ENST00000366699.3	-	5	1143	c.905C>T	c.(904-906)cCt>cTt	p.P302L	TRIM11_ENST00000493030.2_Intron|TRIM11_ENST00000284551.6_Intron|RP11-245P10.8_ENST00000602963.1_RNA|TRIM11_ENST00000460651.1_Intron			Q96F44	TRI11_HUMAN	tripartite motif containing 11	0	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	18		Prostate(94;0.0724)				GTCCTTGGCAGGTCCCCTCCT	0.622000													13	26					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73574719	73574719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73574719C>T	ENST00000224721.6	+	69	9769	c.9764C>T	c.(9763-9765)aCt>aTt	p.T3255I	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Missense_Mutation_p.T1010I	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	3250					calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CTGATACAGACTGAGCTGGAC	0.652000													7	25					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475031	16475031	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16475031G>A	ENST00000358432.5	-	3	819	c.665C>T	c.(664-666)tCc>tTc	p.S222F	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	222	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	AGTGGCCAGGGAAGGTGCATC	0.662000													13	49					0	0	1	0	0
SLC35E4	339665	broad.mit.edu	37	22	31042716	31042716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31042716G>A	ENST00000343605.4	+	2	1550	c.751G>A	c.(751-753)Gac>Aac	p.D251N	SLC35E4_ENST00000406566.1_Intron|SLC35E4_ENST00000300385.8_Intron	NM_001001479.2	NP_001001479.1	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	251	Leu-rich.					integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						CACTGCTGGCGACTCTCGCCT	0.667000													8	30					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49446130	49446130	+	Silent	SNP	C	C	T	rs149962060		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49446130C>T	ENST00000374201.3	-	8	1127	c.825G>A	c.(823-825)gcG>gcA	p.A275A	FRMPD2_ENST00000407470.4_Silent_p.A244A|FRMPD2_ENST00000305531.3_Silent_p.A251A	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	275					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding	p.A275A(1)		NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GCCTCCGGCCCGCCTGCTGGT	0.577000													20	61					0	0	1	0	0
RETNLB	84666	broad.mit.edu	37	3	108475956	108475956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108475956G>A	ENST00000295755.6	-	1	275	c.77C>T	c.(76-78)tCc>tTc	p.S26F		NM_032579.2	NP_115968.1	Q9BQ08	RETNB_HUMAN	resistin like beta	26					cell proliferation	extracellular region	hormone activity			endometrium(1)|kidney(3)|lung(10)|prostate(1)|skin(1)	16						GGAGTCTAAGGAACACTGAGT	0.532000													12	21					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49062078	49062078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:49062078C>T	ENST00000376265.2	-	47	5762	c.5701G>A	c.(5701-5703)Gct>Act	p.A1901T	CACNA1F_ENST00000323022.5_Missense_Mutation_p.A1890T|CACNA1F_ENST00000376251.1_Missense_Mutation_p.A1836T	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1901					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GGACTCACAGCCTCCACCAAG	0.622000													4	8					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84585980	84585980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84585980C>T	ENST00000262753.4	-	7	974	c.829G>A	c.(829-831)Gaa>Aaa	p.E277K	POF1B_ENST00000373145.3_Missense_Mutation_p.E277K	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	277							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TGCAAATGTTCTAATAAGCAG	0.363000													19	23					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793946	17793946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17793946C>T	ENST00000379472.3	+	2	1335	c.1305C>T	c.(1303-1305)atC>atT	p.I435I	KCNC1_ENST00000265969.6_Silent_p.I435I	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	435						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						TGCCCGTCATCGTGAACAATT	0.567000													26	82					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975341	20975341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20975341C>T	ENST00000261383.3	-	53	9864	c.9865G>A	c.(9865-9867)Gag>Aag	p.E3289K	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3289					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATCCGAGTCTCGTCAATCTGC	0.498000													45	106					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28574438	28574438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:28574438C>T	ENST00000220562.4	+	3	1764	c.862C>T	c.(862-864)Ctc>Ttc	p.L288F	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	288						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		ACAGAACCTTCTCTATAACGT	0.522000													8	43					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61847951	61847951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61847951G>A	ENST00000280772.1	-	29	3685	c.3494C>T	c.(3493-3495)tCt>tTt	p.S1165F	ANK3_ENST00000355288.2_Missense_Mutation_p.S299F|ANK3_ENST00000503366.1_Missense_Mutation_p.S1166F|ANK3_ENST00000373827.2_Missense_Mutation_p.S1159F	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1165					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTCTGGGAAAGATGCTTGAAC	0.488000													31	132					0	0	1	0	0
NR1D2	9975	broad.mit.edu	37	3	24003559	24003559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:24003559C>T	ENST00000312521.4	+	5	928	c.609C>T	c.(607-609)ttC>ttT	p.F203F	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117.3	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	203					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						ACAGCCAGTTCAGTGGTCACT	0.458000													16	33					0	0	1	0	0
PNPLA5	150379	broad.mit.edu	37	22	44277460	44277460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44277460C>T	ENST00000216177.4	-	8	1309	c.1177G>A	c.(1177-1179)Gcc>Acc	p.A393T	PNPLA5_ENST00000597664.1_Missense_Mutation_p.A393T|PNPLA5_ENST00000381198.2_Missense_Mutation_p.A279T|PNPLA5_ENST00000593866.1_Missense_Mutation_p.A279T	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	393					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				AGGAGCTGGGCCTTGGTCCTG	0.662000													3	8					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3905638	3905638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3905638G>A	ENST00000450849.2	+	4	810	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	ATCAY_ENST00000600960.1_Missense_Mutation_p.E115K|ATCAY_ENST00000301260.6_Missense_Mutation_p.E115K|ATCAY_ENST00000398448.3_Missense_Mutation_p.E121K	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	115					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GAATGGCAACGAACTGGAGTG	0.577000													25	62					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30260457	30260457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30260457C>T	ENST00000359358.4	-	6	1782	c.1344G>A	c.(1342-1344)acG>acA	p.T448T		NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	448						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GCCATTCATTCGTTTCTAGGT	0.473000													36	78					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13753547	13753547	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13753547G>A	ENST00000265104.4	-	63	10771	c.10667C>T	c.(10666-10668)cCa>cTa	p.P3556L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3556					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTTTCCAAATGGAATTTTCCG	0.398000									Kartagener syndrome				44	116					0	0	1	0	0
CIRH1A	84916	broad.mit.edu	37	16	69184802	69184802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:69184802C>T	ENST00000563094.1	+	8	1031	c.997C>T	c.(997-999)Ccc>Tcc	p.P333S	CIRH1A_ENST00000314423.7_Missense_Mutation_p.P333S|CIRH1A_ENST00000352319.4_Missense_Mutation_p.P333S			Q969X6	CIR1A_HUMAN	cirrhosis, autosomal recessive 1A (cirhin)	333						nucleolus	protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(108;0.125)		AATCACCTTTCCCCACGTAAG	0.542000													18	61					0	0	1	0	0
PROP1	5626	broad.mit.edu	37	5	177419863	177419863	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:177419863A>T	ENST00000308304.2	-	3	836	c.528T>A	c.(526-528)ccT>ccA	p.P176P		NM_006261.4	NP_006252.3	O75360	PROP1_HUMAN	PROP paired-like homeobox 1	176					central nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(9)|stomach(1)	13	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGGCTGGGAAGGGAGGGCAT	0.622000													6	26					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120834	38120834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38120834C>T	ENST00000406386.3	+	7	2526	c.2271C>T	c.(2269-2271)tcC>tcT	p.S757S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	757					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CCAGAGCCTCCTCTCCTAACA	0.572000													38	76					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881021	142881021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142881021C>T	ENST00000446620.1	+	1	510	c.510C>T	c.(508-510)ttC>ttT	p.F170F		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	170					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					TTATTTCCTTCAGTCACAGCA	0.433000													18	59					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7230365	7230365	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7230365A>C	ENST00000379938.2	+	10	2570	c.2033A>C	c.(2032-2034)tAc>tCc	p.Y678S	RREB1_ENST00000334984.6_Missense_Mutation_p.Y678S|RREB1_ENST00000379933.3_Missense_Mutation_p.Y678S|RREB1_ENST00000349384.6_Missense_Mutation_p.Y678S	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	678					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ATCTGCGACTACATCGCCGCC	0.622000													8	60					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9038103	9038103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9038103G>A	ENST00000397910.4	-	8	36376	c.36173C>T	c.(36172-36174)tCc>tTc	p.S12058F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12060	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAGGATGTGGAAATCCCTGG	0.483000													4	3					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584496	7584496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7584496G>A	ENST00000379802.3	+	24	7342	c.7001G>A	c.(7000-7002)cGa>cAa	p.R2334Q	DSP_ENST00000418664.2_Missense_Mutation_p.R1735Q	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2334	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCTGCAGAACGAGCTGTCACT	0.463000													21	56					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55523612	55523612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55523612C>T	ENST00000219070.4	+	7	1565	c.1056C>T	c.(1054-1056)ccC>ccT	p.P352P	MMP2_ENST00000437642.2_Silent_p.P302P|MMP2_ENST00000570308.1_Silent_p.P276P|MMP2_ENST00000543485.1_Silent_p.P276P	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	352	Collagen-binding.|Fibronectin type-II 3.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GTGTCTTCCCCTTCACTTTCC	0.577000													60	141					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55782888	55782888	+	Missense_Mutation	SNP	G	G	A	rs34553661		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55782888G>A	ENST00000373965.2	-	20	2705	c.2311C>T	c.(2311-2313)Cgt>Tgt	p.R771C	PCDH15_ENST00000395445.1_Missense_Mutation_p.R771C|PCDH15_ENST00000409834.1_Missense_Mutation_p.R375C|PCDH15_ENST00000437009.1_Missense_Mutation_p.R693C|PCDH15_ENST00000361849.3_Missense_Mutation_p.R764C|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.R742C|PCDH15_ENST00000395432.2_Missense_Mutation_p.R727C|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373955.1_Missense_Mutation_p.R764C|PCDH15_ENST00000414778.1_Missense_Mutation_p.R769C|PCDH15_ENST00000395430.1_Missense_Mutation_p.R764C|PCDH15_ENST00000320301.6_Missense_Mutation_p.R764C|PCDH15_ENST00000395438.1_Missense_Mutation_p.R764C	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	764	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GATGTGATACGAAAAAGATTA	0.368000										HNSCC(58;0.16)			18	47					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41545673	41545673	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41545673C>T	ENST00000396942.1	-	35	4342		c.e35+1		ANK1_ENST00000289734.7_Splice_Site|ANK1_ENST00000347528.4_Splice_Site|ANK1_ENST00000379758.2_Splice_Site|ANK1_ENST00000352337.4_Splice_Site|ANK1_ENST00000265709.8_Splice_Site|ANK1_ENST00000396945.1_Splice_Site			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic						axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCCCCACTCACCTGCCCAGCT	0.498000													54	183					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57257937	57257937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57257937C>T	ENST00000343433.6	-	2	629	c.549G>A	c.(547-549)agG>agA	p.R183R	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	183										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CCAGCTTTTTCCTGGGTTCCT	0.478000													35	113					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149916067	149916067	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149916067G>A	ENST00000369135.3	-	12	2515	c.2221C>T	c.(2221-2223)Ccc>Tcc	p.P741S		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	741					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TCCTGGTGGGGGTAGGGTCGC	0.637000													24	40					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105180799	105180799	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105180799C>T	ENST00000392634.4	+	21	3412	c.3300C>T	c.(3298-3300)gcC>gcT	p.A1100A	INF2_ENST00000330634.7_Silent_p.A1100A	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	1100					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TGGAGGGGGCCTGGCCGGTGA	0.632000													5	20					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14106380	14106380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:14106380C>T	ENST00000235372.7	+	8	2946	c.2090C>T	c.(2089-2091)aCc>aTc	p.T697I	PRDM2_ENST00000343137.4_Missense_Mutation_p.T496I|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.T496I|PRDM2_ENST00000311066.5_Missense_Mutation_p.T697I|PRDM2_ENST00000505823.1_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	697						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CTTCTTCAAACCCAAGATAAA	0.398000													32	87					0	0	1	0	0
VTCN1	79679	broad.mit.edu	37	1	117712753	117712753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:117712753G>A	ENST00000369458.3	-	2	151	c.73C>T	c.(73-75)Ctc>Ttc	p.L25F	VTCN1_ENST00000328189.3_Missense_Mutation_p.L25F|VTCN1_ENST00000463461.1_5'UTR|VTCN1_ENST00000539893.1_5'UTR|VTCN1_ENST00000359008.4_Missense_Mutation_p.L28F	NM_024626.3	NP_078902.2	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation inhibitor 1	25						integral to membrane|plasma membrane				large_intestine(7)|lung(4)|upper_aerodigestive_tract(1)	12	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		CCAATGATGAGTGCAATTGCT	0.398000													50	115					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162280578	162280578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:162280578G>A	ENST00000389554.3	+	6	2206	c.1889G>A	c.(1888-1890)gGg>gAg	p.G630E	AC009487.5_ENST00000505579.1_RNA|TBR1_ENST00000410035.1_Missense_Mutation_p.G343E	NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	630						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						AGCGACTCGGGGATTTACGAG	0.687000													3	15					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11414274	11414274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:11414274G>A	ENST00000259089.4	+	9	1472	c.880G>A	c.(880-882)Gag>Aag	p.E294K	BLK_ENST00000529894.1_Missense_Mutation_p.E223K|RP11-148O21.4_ENST00000528629.1_RNA	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	294	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TCTGCAGCACGAGCGGCTGGT	0.577000													17	49					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042346	74042346	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74042346G>A	ENST00000409561.1	+	3	1117	c.996G>A	c.(994-996)ggG>ggA	p.G332G		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	332										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						CTGAGCTTGGGGACATTTCAA	0.438000													16	37					0	0	1	0	0
YTHDF3	253943	broad.mit.edu	37	8	64099987	64099987	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:64099987T>C	ENST00000539294.1	+	4	1731	c.1415T>C	c.(1414-1416)tTt>tCt	p.F472S	YTHDF3_ENST00000542911.2_Missense_Mutation_p.F283S|YTHDF3_ENST00000521674.1_3'UTR|YTHDF3_ENST00000517371.1_Intron	NM_001277817.1|NM_001277818.1|NM_152758.4	NP_001264746.1|NP_001264747.1|NP_689971.4	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	473	YTH.											Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			AGTGGACATTTTTGTGGAGTG	0.443000													15	38					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89790008	89790008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89790008C>T	ENST00000568064.1	+	4	943	c.653C>T	c.(652-654)cCa>cTa	p.P218L	ZNF276_ENST00000446326.2_Missense_Mutation_p.P96L|ZNF276_ENST00000443381.2_Silent_p.T299T|ZNF276_ENST00000289816.5_Silent_p.T224T			Q8N554	ZN276_HUMAN	zinc finger protein 276	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GGGCTGAGACCAAGACCCTGC	0.697000													17	38					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159560422	159560422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:159560422G>A	ENST00000307765.5	+	14	1305	c.1054G>A	c.(1054-1056)Ggg>Agg	p.G352R	RXFP1_ENST00000343542.5_Missense_Mutation_p.G304R|RXFP1_ENST00000470033.1_Missense_Mutation_p.G319R|RXFP1_ENST00000460056.2_Missense_Mutation_p.G271R|RXFP1_ENST00000448688.2_Missense_Mutation_p.G247R	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	352						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CAGCCTAGAAGGGATTGAAAT	0.269000													18	46					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35284668	35284668	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:35284668G>A	ENST00000408931.3	-	4	1073	c.545_splice	c.e4-1	p.L183_splice		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	183						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						TGCACATAGAGCCTAAGAAAA	0.353000													9	31					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925637	27925637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:27925637C>T	ENST00000244623.1	+	1	619	c.619C>T	c.(619-621)Cat>Tat	p.H207Y		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGAGCTCTTCCATCTAATACC	0.428000													42	228					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36273299	36273299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36273299C>T	ENST00000007510.4	+	13	1254	c.1110C>T	c.(1108-1110)atC>atT	p.I370I	ARHGAP33_ENST00000378944.5_Silent_p.I234I|ARHGAP33_ENST00000314737.5_Silent_p.I370I			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	370	Rho-GAP.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						GTGAGAGGATCCCGGAGCTGT	0.612000													24	84					0	0	1	0	0
RBM27	54439	broad.mit.edu	37	5	145641171	145641171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145641171C>T	ENST00000265271.5	+	13	2158	c.1992C>T	c.(1990-1992)aaC>aaT	p.N664N	RBM27_ENST00000506502.1_Silent_p.N609N	NM_018989.1	NP_061862.1	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	664	RRM.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(3)|endometrium(4)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTAAACAACCGATTCATTC	0.468000													52	142					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14711348	14711348	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14711348C>A	ENST00000284268.6	-	12	1767	c.1437G>T	c.(1435-1437)gaG>gaT	p.E479D	ANKH_ENST00000535119.1_Missense_Mutation_p.E281D	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	479					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CTGTCACCTCCTCTGTCGGAG	0.532000													90	204					3.1737e-70	3.19671e-70	1	1	0
FAM163A	148753	broad.mit.edu	37	1	179782989	179782989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179782989C>T	ENST00000341785.4	+	5	565	c.169C>T	c.(169-171)Ccc>Tcc	p.P57S		NM_173509.2	NP_775780.1	Q96GL9	F163A_HUMAN	family with sequence similarity 163, member A	57						integral to membrane				endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)	15						TCCCACGCATCCCAGAGGCCC	0.662000													23	60					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117118261	117118261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117118261G>A	ENST00000307564.4	-	14	3163	c.3002C>T	c.(3001-3003)cCt>cTt	p.P1001L	AKNA_ENST00000223791.3_Missense_Mutation_p.P461L|AKNA_ENST00000374075.5_Missense_Mutation_p.P920L|AKNA_ENST00000374088.3_Missense_Mutation_p.P1001L	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1001					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						CTGCCGGAGAGGCCCACTTGG	0.612000													28	39					0	0	1	0	0
OR4S1	256148	broad.mit.edu	37	11	48328209	48328209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48328209C>T	ENST00000319988.1	+	1	435	c.435C>T	c.(433-435)gcC>gcT	p.A145A		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						TAGCGGGGGCCTCCTGGTTAG	0.562000													41	43					0	0	1	0	0
NIM1K	167359	broad.mit.edu	37	5	43246021	43246021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:43246021C>T	ENST00000512796.1	+	2	1643	c.144C>T	c.(142-144)ttC>ttT	p.F48F	NIM1_ENST00000326035.2_Silent_p.F48F			Q8IY84	NIM1_HUMAN		48							ATP binding|magnesium ion binding|protein serine/threonine kinase activity										TGACGCCCTTCGAGAAACTGA	0.582000													22	114					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1268709	1268709	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1268709G>T	ENST00000296820.5	-	7	2383	c.2326C>A	c.(2326-2328)Cct>Act	p.P776T	TERT_ENST00000508104.2_Missense_Mutation_p.P776T|TERT_ENST00000334602.6_Silent_p.I836I|TERT_ENST00000310581.5_Silent_p.I836I			O14746	TERT_HUMAN	telomerase reverse transcriptase	0	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCGTGGAGAGGATGGAGCCCT	0.652000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				12	41					0.00316338	0.00316555	1	1	0
CCT8L2	150160	broad.mit.edu	37	22	17071818	17071818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17071818C>T	ENST00000359963.3	-	1	1882	c.1623G>A	c.(1621-1623)aaG>aaA	p.K541K		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	541					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GTGGGTGTTTCTTTGTCTTCT	0.443000													36	145					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113999622	113999622	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113999622G>A	ENST00000429538.3	-	6	758	c.564C>T	c.(562-564)atC>atT	p.I188I	AC016683.6_ENST00000451179.1_RNA|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000333145.5_RNA|PAX8_ENST00000348715.5_Silent_p.I188I|PAX8_ENST00000263335.7_Silent_p.I188I|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000397647.3_Silent_p.I188I|PAX8_ENST00000263334.5_Silent_p.I188I|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000422956.1_RNA	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	188					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						CAGGCTGAGCGATGCCCAGGA	0.617000			T	PPARG	follicular thyroid		Thyroid dysgenesis						9	19					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84800711	84800711	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:84800711G>C	ENST00000389394.3	+	12	2061	c.1924_splice	c.e12+1	p.D642_splice	DNAH6_ENST00000237449.6_Splice_Site_p.D642_splice|DNAH6_ENST00000398278.2_Splice_Site_p.D642_splice	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	642	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						TCAGGAACCTGGTAACTTGTC	0.363000													40	106					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19553778	19553778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:19553778G>A	ENST00000409832.3	+	1	414	c.362G>A	c.(361-363)gGa>gAa	p.G121E		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	121										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GGCCCTTGGGGAGACTACGAC	0.597000													60	359					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	184009978	184009978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184009978C>T	ENST00000402825.3	+	19	2604	c.2604C>T	c.(2602-2604)tgC>tgT	p.C868C	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000359140.4_Silent_p.C721C|ECE2_ENST00000404464.3_Silent_p.C750C|ECE2_ENST00000357474.5_Silent_p.C796C	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	868	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACTTCGGCTGCCCTGTCGGCT	0.662000													10	68					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62019102	62019102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62019102C>T	ENST00000578147.1	-	24	4616	c.4540G>A	c.(4540-4542)Gat>Aat	p.D1514N	SCN4A_ENST00000435607.1_Missense_Mutation_p.D1514N			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1514					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	AACATATCATCGATGCCCGAC	0.547000													24	73					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20851952	20851952	+	Silent	SNP	G	G	A	rs139781911	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20851952G>A	ENST00000262715.5	-	25	3700	c.3660C>T	c.(3658-3660)acC>acT	p.T1220T	TEP1_ENST00000556935.1_Silent_p.T1112T	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1220	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CACGCAGATAGGTACAGAGGC	0.592000													6	13					0	0	1	0	0
CASD1	64921	broad.mit.edu	37	7	94164787	94164787	+	Silent	SNP	C	C	T	rs146953436	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94164787C>T	ENST00000297273.4	+	8	1082	c.795C>T	c.(793-795)atC>atT	p.I265I		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	265						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AAGAAACCATCATGGAATCTT	0.338000													30	89					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113933979	113933979	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113933979G>A	ENST00000297405.5	-	10	1754	c.1508_splice	c.e10-1	p.L504_splice	CSMD3_ENST00000455883.2_Splice_Site_p.L400_splice|CSMD3_ENST00000343508.3_Splice_Site_p.L464_splice|CSMD3_ENST00000352409.3_Splice_Site_p.L504_splice	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	504	Sushi 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTTGATCCAAGGCTAAAGTTA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	57					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134163082	134163082	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:134163082C>T	ENST00000389887.5	+	9	3351	c.855C>T	c.(853-855)ttC>ttT	p.F285F	GLB1L3_ENST00000431683.2_Silent_p.F285F			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	285					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		AGGATACTTTCAATCAGCTTC	0.478000													12	30					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34888123	34888123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34888123C>T	ENST00000360581.1	+	8	1001	c.873C>T	c.(871-873)ttC>ttT	p.F291F	NPSR1_ENST00000359791.1_Silent_p.F291F|NPSR1_ENST00000381539.3_Silent_p.F291F|NPSR1_ENST00000381542.1_Silent_p.F225F|NPSR1_ENST00000531252.1_Silent_p.F280F	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	291						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	GTCCATACTTCCTGTTTGACA	0.493000													103	272					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159384	152159384	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:152159384C>T	ENST00000439251.1	-	2	1197	c.759G>A	c.(757-759)ccG>ccA	p.P253P	PNMA5_ENST00000535214.1_Silent_p.P253P|PNMA5_ENST00000452693.1_Silent_p.P253P|PNMA5_ENST00000361887.5_Silent_p.P253P	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	253					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCAATCTTCGGAGAGGTCT	0.522000													45	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179599310	179599310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179599310G>A	ENST00000589042.1	-	52	15465	c.15241C>T	c.(15241-15243)Ctt>Ttt	p.L5081F	TTN_ENST00000342992.6_Missense_Mutation_p.L3837F|TTN_ENST00000591111.1_Missense_Mutation_p.L4764F|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4764	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGGCTCAAGAGTTTTGATG	0.368000													28	150					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4718406	4718406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4718406G>A	ENST00000354582.6	+	24	3238	c.2888G>A	c.(2887-2889)gGc>gAc	p.G963D	ITPR1_ENST00000456211.2_Missense_Mutation_p.G939D|ITPR1_ENST00000443694.2_Missense_Mutation_p.G948D|ITPR1_ENST00000423119.2_Missense_Mutation_p.G954D|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.G954D|ITPR1_ENST00000302640.8_Missense_Mutation_p.G948D			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	963					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GCCCCTGAAGGCAATGTGAAG	0.552000													12	23					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143049029	143049029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143049029G>A	ENST00000343257.2	+	23	3025	c.2938G>A	c.(2938-2940)Gag>Aag	p.E980K		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	980					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					ATCCACAGACGAGGAGGATGA	0.622000													27	96					0	0	1	0	0
UBXN6	80700	broad.mit.edu	37	19	4453501	4453501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4453501G>A	ENST00000301281.6	-	3	390	c.266C>T	c.(265-267)gCc>gTc	p.A89V	UBXN6_ENST00000394765.3_Missense_Mutation_p.A36V	NM_025241.2	NP_079517.1	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	89						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						GGTGGCTTCGGCTTGAAGTTC	0.632000													5	31					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418949	8418949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8418949G>A	ENST00000337907.3	-	21	4280	c.3646C>T	c.(3646-3648)Cgc>Tgc	p.R1216C	RERE_ENST00000476556.1_Missense_Mutation_p.R662C|RERE_ENST00000377464.1_Missense_Mutation_p.R948C|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.R1216C	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1216					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R1216C(1)		central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TCACTGAGGCGACCTTCATGC	0.642000													52	69					0	0	1	0	0
TCERG1L	256536	broad.mit.edu	37	10	133058644	133058644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:133058644G>A	ENST00000368642.4	-	4	819	c.734C>T	c.(733-735)gCc>gTc	p.A245V		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	245	Poly-Ala.									cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CATggcagcggcggcggcggt	0.667000													6	11					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207760774	207760774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207760774G>A	ENST00000367049.4	+	34	5574	c.5574G>A	c.(5572-5574)acG>acA	p.T1858T	CR1_ENST00000400960.2_Silent_p.T1408T|CR1_ENST00000367052.1_Silent_p.T1408T|CR1_ENST00000367053.1_Silent_p.T1408T|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367051.1_Silent_p.T1408T|RP11-78B10.2_ENST00000597497.1_RNA	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1408	Sushi 29.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCAGTCCTACGATCCCAATTA	0.438000													25	56					0	0	1	0	0
HMG20A	10363	broad.mit.edu	37	15	77756657	77756657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77756657C>T	ENST00000381714.3	+	4	593	c.165C>T	c.(163-165)ctC>ctT	p.L55L	HMG20A_ENST00000336216.4_Silent_p.L55L	NM_018200.2	NP_060670.1	Q9NP66	HM20A_HUMAN	high mobility group 20A	55					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						TGGAGGATCTCTCTCAAGGTC	0.448000													29	86					0	0	1	0	0
SYT7	9066	broad.mit.edu	37	11	61291930	61291930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61291930C>T	ENST00000263846.4	-	6	1024	c.697G>A	c.(697-699)Gac>Aac	p.D233N	SYT7_ENST00000535826.1_Missense_Mutation_p.D352N|SYT7_ENST00000540831.1_5'UTR|SYT7_ENST00000542836.1_Missense_Mutation_p.D277N|SYT7_ENST00000542670.1_Missense_Mutation_p.D441N|SYT7_ENST00000539008.1_Missense_Mutation_p.D516N|SYT7_ENST00000540677.1_Missense_Mutation_p.D308N	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	233	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CCAATGGGGTCGTTGCGGCTG	0.547000													13	47					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158224974	158224974	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158224974G>A	ENST00000289429.5	+	2	692	c.159G>A	c.(157-159)caG>caA	p.Q53Q		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	53					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GTGATTTGCAGACTCATACCT	0.498000													20	78					0	0	1	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125233416	125233416	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:125233416C>T	ENST00000439075.1	-	0	1329					NR_026876.1																						TCCTGCAATTCCAGTCAATTT	0.393000													7	50					0	0	1	0	0
ENKUR	219670	broad.mit.edu	37	10	25279520	25279520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25279520C>T	ENST00000331161.4	-	4	685	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	ENKUR_ENST00000376363.1_Missense_Mutation_p.E156K	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	156						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						CATATGTATTCAGGTGTGACA	0.348000													6	55					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045401	142045401	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142045401C>T	ENST00000390392.3	+	0	150																											TTCTCTGTCTCCTGGGAGCGG	0.572000													50	151					0	0	1	0	0
MARC1	64757	broad.mit.edu	37	1	220971262	220971262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:220971262C>T	ENST00000366910.5	+	4	845	c.659C>T	c.(658-660)tCg>tTg	p.S220L	MARC1_ENST00000496110.1_3'UTR	NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	220	MOSC.						molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding	p.S220W(1)									TCTGAGGCGTCGCTGGCGGAT	0.438000													14	138					0	0	1	0	0
TRAF7	84231	broad.mit.edu	37	16	2222201	2222201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2222201C>T	ENST00000326181.6	+	8	617	c.485C>T	c.(484-486)cCc>cTc	p.P162L		NM_032271.2	NP_115647.2	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	162					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	23						GAGAAGTGTCCCGTGGACAAC	0.652000													5	22					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142437254	142437254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:142437254C>T	ENST00000378004.3	+	17	1835	c.1480C>T	c.(1480-1482)Cat>Tat	p.H494Y	ARHGAP26_ENST00000274498.4_Missense_Mutation_p.H494Y	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	494	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCCTTGTTCATCGGCTCCC	0.453000													41	129					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886094	23886094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23886094C>T	ENST00000355349.3	-	33	4789	c.4627G>A	c.(4627-4629)Gcc>Acc	p.A1543T		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1543					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCTCCAGGGCTGACTGCAGC	0.602000													28	73					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92428405	92428405	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92428405C>A	ENST00000362005.3	+	3	512	c.94C>A	c.(94-96)Ctt>Att	p.L32I	BRDT_ENST00000394530.3_Missense_Mutation_p.L32I|BRDT_ENST00000370389.2_Intron|BRDT_ENST00000402388.1_Missense_Mutation_p.L32I|BRDT_ENST00000399546.2_Missense_Mutation_p.L32I	NM_001242805.1	NP_001229734.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GACAAATCAACTTCAGTATCT	0.383000													18	176					3.52763e-06	3.53466e-06	1	1	0
ESRP1	54845	broad.mit.edu	37	8	95680211	95680211	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95680211G>A	ENST00000433389.2	+	10	1156	c.966G>A	c.(964-966)aaG>aaA	p.K322K	ESRP1_ENST00000358397.5_Silent_p.K322K|ESRP1_ENST00000454170.2_Silent_p.K322K|ESRP1_ENST00000423620.2_Silent_p.K322K	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	322					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						TTCTCTCCAAGGAAAATCAAG	0.463000													16	43					0	0	1	0	0
TMEM180	79847	broad.mit.edu	37	10	104230440	104230440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104230440C>T	ENST00000238936.4	+	5	507	c.270C>T	c.(268-270)tcC>tcT	p.S90S	TMEM180_ENST00000369931.3_Intron|TMEM180_ENST00000366277.2_Intron	NM_024789.3	NP_079065.2	Q14CX5	TM180_HUMAN	transmembrane protein 180	90						integral to membrane				breast(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|skin(1)	13		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCGGGCTCTCCTCAAGGGCTG	0.697000													32	135					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19178917	19178917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19178917G>A	ENST00000263200.10	-	27	4294	c.4222C>T	c.(4222-4224)Ctg>Ttg	p.L1408L	CLTCL1_ENST00000353891.5_Silent_p.L1408L|CLTCL1_ENST00000427926.1_Silent_p.L1408L|CLTCL1_ENST00000442042.2_5'UTR	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1408	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TAGAACTGCAGGGCTCTGTAA	0.532000			T	?	ALCL								40	74					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56044729	56044729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56044729G>A	ENST00000244728.5	-	3	684	c.287C>T	c.(286-288)tCa>tTa	p.S96L	COL21A1_ENST00000535941.1_Missense_Mutation_p.S96L|COL21A1_ENST00000370819.1_Missense_Mutation_p.S96L	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	96	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ATGTTCTCCTGAATCATAGCT	0.448000													9	36					0	0	1	0	0
IL32	9235	broad.mit.edu	37	16	3119049	3119049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3119049C>T	ENST00000525643.2	+	7	592	c.260C>T	c.(259-261)tCc>tTc	p.S87F	IL32_ENST00000551513.1_Missense_Mutation_p.S124F|IL32_ENST00000528163.2_Missense_Mutation_p.S87F|IL32_ENST00000552936.1_Missense_Mutation_p.S111F|IL32_ENST00000552356.1_Missense_Mutation_p.S67F|IL32_ENST00000526464.2_Missense_Mutation_p.S87F|IL32_ENST00000549213.1_Missense_Mutation_p.S87F|IL32_ENST00000529550.1_Missense_Mutation_p.S87F|IL32_ENST00000530538.2_Missense_Mutation_p.S87F|IL32_ENST00000531965.1_Missense_Mutation_p.S77F|IL32_ENST00000396887.3_Missense_Mutation_p.S87F|IL32_ENST00000008180.9_Missense_Mutation_p.S67F|IL32_ENST00000440815.3_Missense_Mutation_p.S87F|IL32_ENST00000325568.5_Missense_Mutation_p.S87F|IL32_ENST00000548652.1_Missense_Mutation_p.S78F|IL32_ENST00000548246.1_Missense_Mutation_p.S47F|IL32_ENST00000533097.2_Missense_Mutation_p.S87F|IL32_ENST00000534507.1_Missense_Mutation_p.S133F|IL32_ENST00000548476.1_Missense_Mutation_p.S133F|IL32_ENST00000552664.1_Missense_Mutation_p.S87F|IL32_ENST00000396890.2_Missense_Mutation_p.S133F|IL32_ENST00000444393.3_Missense_Mutation_p.S87F|IL32_ENST00000382213.3_Missense_Mutation_p.S78F|IL32_ENST00000530890.1_Missense_Mutation_p.S67F|IL32_ENST00000551122.1_Missense_Mutation_p.S87F|IL32_ENST00000529699.1_Missense_Mutation_p.S67F			P24001	IL32_HUMAN	interleukin 32	133					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						GGCAACAGATCCCCTGTCCCG	0.567000													5	19					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100454649	100454649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100454649C>T	ENST00000354161.3	+	5	733	c.608C>T	c.(607-609)tCc>tTc	p.S203F	SLC12A9_ENST00000415287.1_Missense_Mutation_p.S114F|SLC12A9_ENST00000275729.3_Missense_Mutation_p.S114F|SLC12A9_ENST00000540482.1_Missense_Mutation_p.S203F|SLC12A9_ENST00000428758.1_Missense_Mutation_p.S203F	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	203						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					GTCTCTGGCTCCCTGGCCTCT	0.652000													37	97					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691754	153691754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:153691754G>A	ENST00000304337.2	-	2	1223	c.403C>T	c.(403-405)Cgt>Tgt	p.R135C		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	135	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					GATTTAAAACGATCCAGCCAA	0.413000													72	59					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	10992758	10992758	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:10992758G>A	ENST00000304623.8	-	19	3305	c.3116C>T	c.(3115-3117)tCg>tTg	p.S1039L	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.S702L|CTNND2_ENST00000511377.1_Missense_Mutation_p.S948L|CTNND2_ENST00000458100.2_Missense_Mutation_p.S606L|CTNND2_ENST00000359640.2_Missense_Mutation_p.S981L	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1039					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GGTTGAAGACGAGGCTACAAA	0.542000													37	129					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697558	6697558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6697558C>T	ENST00000245907.6	-	21	2685	c.2593G>A	c.(2593-2595)Gaa>Aaa	p.E865K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	865					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGGAGTAGTTCCACCCTCACC	0.612000													9	37					0	0	1	0	0
OR1G1	8390	broad.mit.edu	37	17	3030699	3030699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3030699G>A	ENST00000328890.2	-	1	176	c.147C>T	c.(145-147)atC>atT	p.I49I		NM_003555.1	NP_003546.1	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G, member 1	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(3)|skin(3)	11						TGTCAGTAATGATGACTAGAA	0.522000													25	41					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5294911	5294911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5294911G>A	ENST00000546004.1	-	2	351	c.105C>T	c.(103-105)ctC>ctT	p.L35L	PROKR2_ENST00000217270.3_Silent_p.L35L			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	35						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CATCCATAGGGAGGTCATAAT	0.517000										HNSCC(71;0.22)			16	91					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604076	179604076	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179604076G>A	ENST00000589042.1	-	48	14108	c.13884C>T	c.(13882-13884)tcC>tcT	p.S4628S	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Silent_p.S4311S|TTN_ENST00000342175.6_Silent_p.S4457S|TTN_ENST00000359218.5_Silent_p.S4390S|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.S4265S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4311	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTTGTTATGGATGTTGTGA	0.388000													7	51					0	0	1	0	0
LIPK	643414	broad.mit.edu	37	10	90492287	90492287	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90492287C>T	ENST00000404190.1	+	5	648	c.648C>T	c.(646-648)acC>acT	p.T216T		NM_001080518.1	NP_001073987.1	Q5VXJ0	LIPK_HUMAN	lipase, family member K	216					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	12		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		AACTAACAACCCTTTCCAGGC	0.363000													55	201					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51503250	51503250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51503250G>A	ENST00000396402.1	-	10	1420	c.1267C>T	c.(1267-1269)Cct>Tct	p.P423S	CYP19A1_ENST00000559878.1_Missense_Mutation_p.P423S|CYP19A1_ENST00000260433.2_Missense_Mutation_p.P423S|RP11-108K3.1_ENST00000559909.1_lincRNA|CYP19A1_ENST00000396404.4_Missense_Mutation_p.P423S	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	423					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	TACCTATAAGGAACCTATGAA	0.443000													12	39					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19047005	19047005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19047005G>A	ENST00000421369.3	+	7	1093	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K	TMC7_ENST00000304381.5_Missense_Mutation_p.E289K|TMC7_ENST00000569532.1_Missense_Mutation_p.E289K|TMC7_ENST00000561963.1_3'UTR	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	289						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						CAGGTCGGTGGAAGGATTCAA	0.438000													16	83					0	0	1	0	0
KRT32	3882	broad.mit.edu	37	17	39622349	39622349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39622349G>A	ENST00000225899.3	-	2	651	c.548C>T	c.(547-549)gCc>gTc	p.A183V		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	183	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				AACTCACTTGGCCCTGAAGTC	0.547000													5	71					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105415962	105415962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105415962C>T	ENST00000333244.5	-	7	5945	c.5826G>A	c.(5824-5826)gtG>gtA	p.V1942V	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1942						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CGGGGGCTGTCACTTCCGCCT	0.612000													102	250					0	0	1	0	0
MAN1B1	11253	broad.mit.edu	37	9	139983393	139983393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139983393C>T	ENST00000371589.4	+	3	474	c.401C>T	c.(400-402)cCc>cTc	p.P134L		NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	134					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		GCAAATCCACCCGTCTTACCA	0.473000													35	101					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23238964	23238964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23238964G>A	ENST00000400191.3	+	15	2742	c.2724G>A	c.(2722-2724)acG>acA	p.T908T	EPHB2_ENST00000374632.3_Silent_p.T909T|EPHB2_ENST00000374630.3_Silent_p.T908T|EPHB2_ENST00000374627.1_Silent_p.T903T	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	908					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TGGACCGCACGATCCCCGACT	0.617000													23	80					0	0	1	0	0
CEP112	201134	broad.mit.edu	37	17	63847976	63847976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:63847976C>T	ENST00000392769.2	-	21	2558	c.2340G>A	c.(2338-2340)atG>atA	p.M780I	CEP112_ENST00000580482.1_5'UTR|CEP112_ENST00000541355.1_Missense_Mutation_p.M415I|CEP112_ENST00000535342.2_Missense_Mutation_p.M780I|CEP112_ENST00000537949.1_Missense_Mutation_p.M738I	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	780						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						GCTCTATTTTCATCTTTTCTG	0.388000													73	167					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27505662	27505662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27505662G>A	ENST00000296098.4	+	1	333	c.63G>A	c.(61-63)gaG>gaA	p.E21E	TRIM54_ENST00000380075.2_Silent_p.E21E	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	21					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAACCTGGAGAAGCAGCTCA	0.592000													74	196					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256058	16256058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16256058C>T	ENST00000375759.3	+	11	3527	c.3323C>T	c.(3322-3324)cCc>cTc	p.P1108L		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1108					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AAGCCCATTCCCTCAAAACCA	0.463000													12	38					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572881	38572881	+	Missense_Mutation	SNP	C	C	T	rs147366609		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38572881C>T	ENST00000222345.6	+	3	1185	c.676C>T	c.(676-678)Cgc>Tgc	p.R226C		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	226					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GAACGAGTTCCGCAGCGAGCA	0.706000													21	70					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23329128	23329128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23329128G>A	ENST00000597761.2	+	4	1481	c.1282G>A	c.(1282-1284)Gaa>Aaa	p.E428K		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						CAAATGTGAAGAATGTGGCAG	0.388000													24	55					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045593	53045593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53045593C>T	ENST00000309680.3	-	1	355	c.334G>A	c.(334-336)Ggt>Agt	p.G112S		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	112	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		ccaccgaaaccaccaccactg	0.637000													4	14					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46246393	46246393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:46246393C>T	ENST00000334344.6	+	15	4659	c.4487C>T	c.(4486-4488)tCt>tTt	p.S1496F	ARID2_ENST00000422737.1_Missense_Mutation_p.S1347F|ARID2_ENST00000444670.1_Missense_Mutation_p.S1106F|ARID2_ENST00000457135.1_Missense_Mutation_p.S104F|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1496					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GTATCCCATTCTCCTGCCCTA	0.468000			"""N, S, F"""		hepatocellular carcinoma								31	112					0	0	1	0	0
PDIA2	64714	broad.mit.edu	37	16	335186	335186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:335186G>A	ENST00000219406.6	+	5	799	c.781G>A	c.(781-783)Gag>Aag	p.E261K	PDIA2_ENST00000462950.1_3'UTR|PDIA2_ENST00000404312.1_Missense_Mutation_p.E258K	NM_006849.2	NP_006840.2	Q13087	PDIA2_HUMAN	protein disulfide isomerase family A, member 2	261					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			breast(1)|central_nervous_system(4)|kidney(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	17		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CCTGGTCACGGAGTTCAACAG	0.662000													6	43					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825119	4825119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4825119G>A	ENST00000380382.1	-	1	728	c.729C>T	c.(727-729)ttC>ttT	p.F243F	MMP26_ENST00000477339.1_Intron|OR52R1_ENST00000356069.2_Silent_p.F164F|MMP26_ENST00000380390.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TAGACACCATGAAGCAGAAGG	0.547000													12	78					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216077	140216077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140216077C>T	ENST00000525929.1	+	1	2109	c.2109C>T	c.(2107-2109)gcC>gcT	p.A703A	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.A703A|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATCATCGCCATCTGCGCGG	0.612000													13	135					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159605610	159605610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159605610G>A	ENST00000337808.6	+	5	1687	c.1110G>A	c.(1108-1110)atG>atA	p.M370I	IQCJ-SCHIP1_ENST00000476809.1_Missense_Mutation_p.M419I|IQCJ-SCHIP1_ENST00000460298.1_Missense_Mutation_p.M330I|SCHIP1_ENST00000482804.1_Missense_Mutation_p.M143I|IQCJ-SCHIP1_ENST00000485419.1_Missense_Mutation_p.M446I|SCHIP1_ENST00000445224.2_Missense_Mutation_p.M127I|IQCJ-SCHIP1_ENST00000412423.2_Missense_Mutation_p.M357I|IQCJ-SCHIP1_ENST00000527095.1_Missense_Mutation_p.M138I	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		370						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						AAGCCAAAATGGCCCTTGCCA	0.453000													35	101					0	0	1	0	0
AKR1C1	1645	broad.mit.edu	37	10	5006069	5006069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5006069G>A	ENST00000380859.1	+	1	89	c.74G>A	c.(73-75)gGa>gAa	p.G25E	AKR1C1_ENST00000434459.2_Intron|AKR1C1_ENST00000380872.4_Intron|AKR1C1_ENST00000477661.1_Intron					aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						CAATTCAGAGGAATTTTTATG	0.418000													14	61					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904960	55904960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55904960G>A	ENST00000301529.1	-	1	234	c.235C>T	c.(235-237)Cct>Tct	p.P79S		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P79N(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AGCATTTTAGGGGCAATGACA	0.418000													56	102					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157667107	157667107	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157667107G>A	ENST00000368184.3	-	6	958	c.667C>T	c.(667-669)Cag>Tag	p.Q223*	FCRL3_ENST00000368186.5_Nonsense_Mutation_p.Q223*|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	223	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AATTGCAGCTGGACATCTGGC	0.587000													37	70					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64275848	64275848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:64275848C>T	ENST00000261891.3	-	2	203	c.198G>A	c.(196-198)gtG>gtA	p.V66V	DAPK2_ENST00000558069.1_Silent_p.V66V|DAPK2_ENST00000558482.1_5'UTR|DAPK2_ENST00000457488.1_Silent_p.V66V			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	66	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		CCTCCCGGCTCACACCGCGCC	0.622000													14	77					0	0	1	0	0
NPTN	27020	broad.mit.edu	37	15	73862580	73862580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73862580G>A	ENST00000351217.6	-	5	1595	c.677C>T	c.(676-678)cCt>cTt	p.P226L	NPTN_ENST00000287226.8_Missense_Mutation_p.L326F|NPTN_ENST00000542234.1_Missense_Mutation_p.P137L|NPTN_ENST00000345330.4_Missense_Mutation_p.P342L|NPTN_ENST00000563691.1_Missense_Mutation_p.P342L|NPTN_ENST00000562924.1_Missense_Mutation_p.P226L|NPTN_ENST00000545878.1_Missense_Mutation_p.P342L	NM_001161364.1|NM_017455.3	NP_001154836.1|NP_059429.1	Q9Y639	NPTN_HUMAN	neuroplastin	342	Ig-like 2.				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	13						TCCCAAGAAAGGCCAGAGTGG	0.527000													17	129					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86415993	86415993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86415993C>T	ENST00000361669.2	+	3	1984	c.885C>T	c.(883-885)ttC>ttT	p.F295F	GRM3_ENST00000394720.2_Silent_p.F293F|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Silent_p.F295F|GRM3_ENST00000536043.1_Silent_p.F167F	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	295					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ATGCCTCCTTCACCTGGGTGG	0.677000													29	55					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50222931	50222931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50222931G>A	ENST00000002829.3	+	14	1996	c.1512G>A	c.(1510-1512)gaG>gaA	p.E504E	SEMA3F_ENST00000413852.1_Silent_p.E405E|SEMA3F_ENST00000434342.1_Silent_p.E473E	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	504	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		AGGAGTTGGAGGAGCTCATGC	0.647000													8	23					0	0	1	0	0
MIR409	574413	broad.mit.edu	37	14	101531683	101531683	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101531683G>A	ENST00000362237.1	+	0	47					NR_029975.1																						TCTGGACGACGAATGTTGCTC	0.582000													37	44					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43859674	43859674	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43859674G>A	ENST00000378009.4	+	0	421				CD177_ENST00000378012.2_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane		p.M129I(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CAGATCCCATGATGGGAGCTG	0.517000													5	14					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460402	107460402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107460402C>T	ENST00000409382.3	-	2	642	c.32G>A	c.(31-33)cGa>cAa	p.R11Q	ST6GAL2_ENST00000409087.3_Missense_Mutation_p.R11Q|ST6GAL2_ENST00000361686.4_Missense_Mutation_p.R11Q	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	11					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.R11Q(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GAAAAGCATTCGTTGTCTCCA	0.507000													23	47					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940841	22940841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22940841C>T	ENST00000397104.3	-	5	1596	c.1597G>A	c.(1597-1599)Gaa>Aaa	p.E533K	ZNF99_ENST00000596209.1_Missense_Mutation_p.E624K					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CCACATTCTTCACATTTGTAG	0.383000													18	80					0	0	1	0	0
ALDH1A3	220	broad.mit.edu	37	15	101434167	101434167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101434167C>T	ENST00000329841.5	+	6	1078	c.546C>T	c.(544-546)ttC>ttT	p.F182F	RP11-66B24.4_ENST00000560351.1_RNA|ALDH1A3_ENST00000346623.6_Intron	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	182					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	AGTGGAACTTCCCCCTGCTGA	0.597000													32	188					0	0	1	0	0
RAI2	10742	broad.mit.edu	37	X	17819929	17819929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:17819929C>T	ENST00000545871.1	-	3	662	c.202G>A	c.(202-204)Ggc>Agc	p.G68S	RAI2_ENST00000415486.3_Intron|RAI2_ENST00000360011.1_Missense_Mutation_p.G68S|RP3-389A20.4_ENST00000509491.2_Intron|RAI2_ENST00000451717.1_Missense_Mutation_p.G68S|RAI2_ENST00000331511.1_Missense_Mutation_p.G68S	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	68					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					AGAGCCATGCCACTCTGAGAC	0.627000													53	53					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776758	5776758	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5776758C>T	ENST00000317254.3	+	1	836	c.788C>T	c.(787-789)tCc>tTc	p.S263F	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TCCTTCTTTTCCCACCGCTTT	0.478000													45	142					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	12933942	12933942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:12933942G>A	ENST00000379348.2	+	4	505	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	PHACTR1_ENST00000379350.1_Intron|PHACTR1_ENST00000332995.7_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	0						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TCTTGGGCTCGAACTGTGTTC	0.532000													46	90					0	0	1	0	0
USO1	8615	broad.mit.edu	37	4	76695903	76695903	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76695903C>T	ENST00000538159.1	+	8	636	c.636C>T	c.(634-636)ttC>ttT	p.F212F	USO1_ENST00000514213.2_Silent_p.F195F			O60763	USO1_HUMAN	USO1 vesicle transport factor	210	Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AAAATGCTTTCGAGAGACTAC	0.383000													39	108					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644428	169644428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169644428C>T	ENST00000428432.2	+	6	767	c.378C>T	c.(376-378)ttC>ttT	p.F126F	SAMD7_ENST00000335556.3_Silent_p.F126F	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	126										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GGATACCCTTCCTCTATGGCT	0.502000													32	76					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191941038	191941038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:191941038C>T	ENST00000392320.2	-	4	601	c.287G>A	c.(286-288)gGa>gAa	p.G96E	STAT4_ENST00000358470.4_Missense_Mutation_p.G96E	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	96					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			CATTGGATTTCCATGAAATTT	0.333000													25	93					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17579354	17579354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17579354G>A	ENST00000381861.3	-	1	376	c.57C>T	c.(55-57)atC>atT	p.I19I	MTUS1_ENST00000262102.6_Intron|MTUS1_ENST00000381869.3_Intron|MTUS1_ENST00000519263.1_Intron|MTUS1_ENST00000544260.1_Intron	NM_001001931.2	NP_001001931.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	0						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		AATTGATAAAGATTTTTGAAG	0.423000													32	46					0	0	1	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43678790	43678790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:43678790C>T	ENST00000374466.3	+	8	1764	c.1429C>T	c.(1429-1431)Ccg>Tcg	p.P477S		NM_018590.3	NP_061060.3	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 2	477					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GATTCGGACTCCGGTTCCTGG	0.478000													78	165					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109844602	109844602	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109844602G>A	ENST00000310903.5	+	9	1030	c.924G>A	c.(922-924)ggG>ggA	p.G308G	MYO1H_ENST00000542883.1_3'UTR|MYO1H_ENST00000431443.2_Silent_p.G308G			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						AGCTCCTGGGGGTCCACCCAT	0.438000													21	57					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98189039	98189039	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98189039C>T	ENST00000332650.5	+	1	716	c.619C>T	c.(619-621)Caa>Taa	p.Q207*		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGGTTCAGTTCAAGTCTTTAC	0.343000													53	148					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632737	122632737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122632737G>A	ENST00000195173.4	-	15	2403	c.2100C>T	c.(2098-2100)ggC>ggT	p.G700G	SEMA5B_ENST00000451055.2_Silent_p.G754G|SEMA5B_ENST00000357599.3_Silent_p.G700G			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	700	TSP type-1 1.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		CGCAGATGCGGCCCCCGTGGC	0.667000													30	72					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37617990	37617990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37617990C>T	ENST00000399151.3	+	19	3797	c.3712C>T	c.(3712-3714)Cgg>Tgg	p.R1238W		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1238					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CTACGACTCTCGGCGGGTCCT	0.582000													19	38					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8689378	8689378	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:8689378C>T	ENST00000378641.3	+	12	1704	c.1229C>T	c.(1228-1230)tCg>tTg	p.S410L	PLCB1_ENST00000338037.6_Missense_Mutation_p.S410L|PLCB1_ENST00000378637.2_Missense_Mutation_p.S410L	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	410	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ATTCTCCTTTCGTTTGAGAAC	0.358000													21	36					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48626890	48626890	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48626890G>A	ENST00000328333.8	-	17	2291	c.2184C>T	c.(2182-2184)tcC>tcT	p.S728S	COL7A1_ENST00000454817.1_Silent_p.S728S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	728	Fibronectin type-III 6.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AAACCAACTGGGATTTCTCTG	0.622000													29	58					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759246	121759246	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121759246G>A	ENST00000261367.7	+	6	2383	c.955G>A	c.(955-957)Gag>Aag	p.E319K	SNCAIP_ENST00000261368.8_Missense_Mutation_p.E272K|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E272K|SNCAIP_ENST00000503116.2_Missense_Mutation_p.E319K|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E319K			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	272					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TCGAAAAGTTGAGAAGACAAC	0.488000													15	40					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186669961	186669961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:186669961G>A	ENST00000343098.5	+	17	16195	c.16195G>A	c.(16195-16197)Ggc>Agc	p.G5399S	FSIP2_ENST00000424728.1_Missense_Mutation_p.G5310S	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AGATATTATGGGCTTGGCTCT	0.308000													58	133					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16769358	16769358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:16769358C>T	ENST00000381323.3	-	3	250	c.30G>A	c.(28-30)agG>agA	p.R10R	FAM49A_ENST00000406434.1_Silent_p.R10R|FAM49A_ENST00000355549.2_Silent_p.R10R	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	10						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TTTCAATTTCCCTGGTAAGGA	0.333000													28	45					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103488537	103488537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103488537C>T	ENST00000358392.2	-	8	1359	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	COL11A1_ENST00000512756.1_Intron|COL11A1_ENST00000353414.4_Missense_Mutation_p.E297K|COL11A1_ENST00000370096.3_Missense_Mutation_p.E336K	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	336	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTAAATATTTCTTCAACTGGA	0.318000													12	36					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17107960	17107960	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17107960C>T	ENST00000443236.1	-	11	1228	c.1197G>A	c.(1195-1197)acG>acA	p.T399T	CPAMD8_ENST00000388925.4_Silent_p.T352T	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	352						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						ACTGCTTCCTCGTGTCCTTGG	0.637000													24	40					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939556	12939556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12939556G>A	ENST00000235349.5	-	4	1316	c.1246C>T	c.(1246-1248)Cct>Tct	p.P416S		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	416										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CGGGGGGCAGGATACAGCTCC	0.512000													71	642					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40773888	40773888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40773888C>T	ENST00000372748.3	-	17	972	c.876G>A	c.(874-876)ggG>ggA	p.G292G		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	292	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			GGCCTGTGATCCCCTGGGGTC	0.627000													13	26					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110226283	110226283	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110226283G>A	ENST00000418703.2	-	12	2224	c.2130C>T	c.(2128-2130)ctC>ctT	p.L710L	TRPV4_ENST00000541794.1_Silent_p.L663L|TRPV4_ENST00000537083.1_Silent_p.L650L|TRPV4_ENST00000261740.2_Silent_p.L710L|TRPV4_ENST00000392719.2_Silent_p.L663L|TRPV4_ENST00000536838.1_Silent_p.L676L|TRPV4_ENST00000346520.2_Silent_p.L650L|TRPV4_ENST00000544971.1_Silent_p.L603L	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	710					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						GCATGTTGAGGAGCAGCACAA	0.602000													22	66					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3581927	3581927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3581927C>T	ENST00000315677.3	-	8	2506	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	DLGAP1_ENST00000400149.3_Silent_p.E327E|DLGAP1_ENST00000581699.1_Silent_p.E343E|DLGAP1_ENST00000400150.3_Silent_p.E353E|DLGAP1_ENST00000400145.2_Silent_p.E335E|DLGAP1_ENST00000581527.1_Silent_p.E637E|DLGAP1_ENST00000539435.1_Silent_p.E345E|DLGAP1_ENST00000400155.1_Silent_p.E343E|DLGAP1_ENST00000400147.2_Silent_p.E335E|DLGAP1_ENST00000534970.1_Silent_p.E321E|DLGAP1_ENST00000515196.2_Silent_p.E637E|DLGAP1_ENST00000584874.1_Silent_p.E637E	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	637					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				TCTTCCTGTCCTCCgtggtga	0.493000													43	100					0	0	1	0	0
MORN5	254956	broad.mit.edu	37	9	124929162	124929162	+	Missense_Mutation	SNP	G	G	A	rs138145529		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:124929162G>A	ENST00000536616.1	+	2	201	c.163G>A	c.(163-165)Gac>Aac	p.D55N	MORN5_ENST00000486801.1_3'UTR|MORN5_ENST00000373764.3_Missense_Mutation_p.D55N			Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	55										endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	9						AAGCCAATACGACGCCATTTG	0.537000													5	34					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175299218	175299218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175299218C>T	ENST00000367674.1	-	21	4493	c.3785G>A	c.(3784-3786)gGc>gAc	p.G1262D	TNR_ENST00000263525.2_Missense_Mutation_p.G1262D|RP3-518E13.2_ENST00000569593.1_RNA	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1262	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACCCGCAGTGCCGTTGTAGCT	0.592000													21	52					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116955341	116955341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:116955341G>A	ENST00000265441.3	-	3	671	c.372C>T	c.(370-372)acC>acT	p.T124T	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	124					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TACAGGCCCTGGTGATGGCAA	0.473000													17	83					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277283	114277283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114277283C>T	ENST00000357077.4	+	38	7562	c.7509C>T	c.(7507-7509)gcC>gcT	p.A2503A	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.A2470A|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2470					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CGGAAGTGGCCTCTGTGCGGT	0.532000													35	99					0	0	1	0	0
PRSS42	339906	broad.mit.edu	37	3	46874578	46874578	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46874578G>A	ENST00000447340.1	-	2	231	c.178C>T	c.(178-180)Cga>Tga	p.R60*	PRSS42_ENST00000429665.1_Nonsense_Mutation_p.R164*			Q7Z5A4	PRS42_HUMAN	protease, serine, 42	164					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	8						AGGTCATTTCGAATGGTTGTA	0.458000													32	52					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65425637	65425637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:65425637C>T	ENST00000330909.8	-	9	1186	c.1187G>A	c.(1186-1188)cGg>cAg	p.R396Q	MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000402939.2_Missense_Mutation_p.R396Q|MAGI1_ENST00000483466.1_Missense_Mutation_p.R396Q|MAGI1_ENST00000497477.2_Missense_Mutation_p.R396Q	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	396					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CTGCTTCTTCCGTTTGGCTTC	0.517000											OREG0015658	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	82					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842090	5842090	+	Silent	SNP	C	C	T	rs146871183		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5842090C>T	ENST00000317037.2	+	1	547	c.525C>T	c.(523-525)ttC>ttT	p.F175F	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGGGAACTTCATCCCCCACA	0.512000													45	134					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95085657	95085657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95085657G>A	ENST00000553947.1	+	6	1732	c.844G>A	c.(844-846)Gag>Aag	p.E282K	SERPINA3_ENST00000467132.1_Missense_Mutation_p.E257K|SERPINA3_ENST00000393080.4_Missense_Mutation_p.E257K|SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000482740.1_Missense_Mutation_p.E39K|SERPINA3_ENST00000393078.3_Missense_Mutation_p.E257K			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	257					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity	p.E257K(1)		NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		CTTCCGGGACGAGGAGCTGTC	0.502000													26	43					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48753420	48753420	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48753420G>A	ENST00000285238.8	+	22	3116	c.3036G>A	c.(3034-3036)ctG>ctA	p.L1012L	ABCC3_ENST00000510891.1_3'UTR	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1012	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCCTGAGGCTGGGCGTCTATG	0.557000													5	48					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540430	55540430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55540430G>A	ENST00000220676.1	+	4	4136	c.3988G>A	c.(3988-3990)Gat>Aat	p.D1330N		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1330					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGCCCAATTGATGAGACCTA	0.393000													34	132					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204948579	204948579	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204948579C>T	ENST00000367172.4	+	19	2396	c.2068C>T	c.(2068-2070)Ctc>Ttc	p.L690F	NFASC_ENST00000513543.1_Missense_Mutation_p.L686F|NFASC_ENST00000338586.6_Missense_Mutation_p.L690F|NFASC_ENST00000367169.4_Missense_Mutation_p.L690F|NFASC_ENST00000360049.4_Missense_Mutation_p.L686F|NFASC_ENST00000367171.4_Missense_Mutation_p.L675F|NFASC_ENST00000401399.1_Missense_Mutation_p.L690F|NFASC_ENST00000539706.1_Missense_Mutation_p.L686F|NFASC_ENST00000367170.4_Missense_Mutation_p.L690F|NFASC_ENST00000339876.6_Missense_Mutation_p.L690F|NFASC_ENST00000404907.1_Missense_Mutation_p.L686F|NFASC_ENST00000404076.1_Missense_Mutation_p.L669F|NFASC_ENST00000338515.6_Missense_Mutation_p.L690F			O94856	NFASC_HUMAN	neurofascin	690	Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTCAGCCGTCCTCCGGCTGTC	0.587000													36	150					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340447	121340447	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121340447C>T	ENST00000338040.4	+	3	585	c.171C>T	c.(169-171)ctC>ctT	p.L57L		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	57					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		ACCAGCTCCTCTGCCCTTTAG	0.587000													30	76					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703934	4703934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4703934G>A	ENST00000396950.3	-	2	247	c.8C>T	c.(7-9)tCc>tTc	p.S3F		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GAAGTTGCAGGAACTCATAGC	0.507000													17	31					0	0	1	0	0
ARMC4P1	101060171	broad.mit.edu	37	10	27577691	27577691	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27577691G>A	ENST00000576034.1	+	0	581																											CCATCGTCAGGAAGCAAGTGC	0.403000													8	51					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52400880	52400880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52400880G>A	ENST00000420323.2	+	36	6003	c.5742G>A	c.(5740-5742)gaG>gaA	p.E1914E		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1914	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGTACGGGGAGTTTGACCTCC	0.622000													37	97					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676172	123676172	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123676172C>T	ENST00000309154.2	-	1	923	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CTCAACACTTCCTGTACCTTC	0.408000													38	124					0	0	1	0	0
C1orf109	54955	broad.mit.edu	37	1	38155359	38155359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38155359G>A	ENST00000358011.4	-	2	383	c.194C>T	c.(193-195)gCc>gTc	p.A65V	C1orf109_ENST00000494120.1_5'UTR	NM_017850.1	NP_060320.1	Q9NX04	CA109_HUMAN	chromosome 1 open reading frame 109	65										lung(2)|prostate(2)	4		Myeloproliferative disorder(586;0.0393)				ATCTGGGAAGGCCCGAAGCGC	0.622000													41	81					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111090596	111090596	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:111090596G>A	ENST00000262839.2	-	6	2364	c.1446C>T	c.(1444-1446)ttC>ttT	p.F482F		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	482					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGGATATTGCGAAGAGTGCTT	0.483000													18	24					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47041164	47041164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47041164C>T	ENST00000450053.3	+	26	3927	c.3748C>T	c.(3748-3750)Ctc>Ttc	p.L1250F	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Intron	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1250	Leu-rich.						binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		ACAGCTGTCCCTCCAGGCTGA	0.607000													10	39					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104081960	104081960	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104081960C>T	ENST00000388887.2	+	28	3216	c.3012C>T	c.(3010-3012)ctC>ctT	p.L1004L		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1004	FAS1 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TGTCATTTCTCTCCGAAGCAG	0.378000													53	103					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105331392	105331392	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105331392C>T	ENST00000369780.4	+	3	871	c.462C>T	c.(460-462)gcC>gcT	p.A154A	NEURL_ENST00000369777.2_Silent_p.A137A	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		154	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GCTTCTGGGCCAAGGCGCTGC	0.622000													18	34					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163031436	163031436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163031436C>T	ENST00000188790.4	-	22	2117	c.1910G>A	c.(1909-1911)gGa>gAa	p.G637E	FAP_ENST00000443424.1_Missense_Mutation_p.G612E	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	637					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						AAGACCAGTTCCAGATGCAAG	0.408000													21	39					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210414908	210414908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210414908C>T	ENST00000367012.3	+	4	527	c.297C>T	c.(295-297)atC>atT	p.I99I	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	99							protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TGTAGACCATCTCAATTTTTG	0.328000													18	66					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71469630	71469630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71469630G>A	ENST00000322937.6	+	12	893	c.790G>A	c.(790-792)Gaa>Aaa	p.E264K	AMBN_ENST00000449493.2_Missense_Mutation_p.E249K	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	264					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			GAGTTCAGAAGAAGTGGCAGT	0.423000													15	49					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461415	48461415	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48461415G>A	ENST00000358536.4	-	11	2549	c.2280C>T	c.(2278-2280)tcC>tcT	p.S760S	PLXNB1_ENST00000296440.6_Silent_p.S760S|PLXNB1_ENST00000358459.4_Intron|PLXNB1_ENST00000456774.1_Intron|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	760	Pro-rich.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCTGGGAGGGGAGGGCTCCT	0.657000													7	18					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23019033	23019033	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23019033C>T	ENST00000327968.5	+	1	947	c.859C>T	c.(859-861)Caa>Taa	p.Q287*	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	287	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						TCTTGATTCTCAACCAATATC	0.418000													36	31					0	0	1	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176525	142176525	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142176525G>A	ENST00000390369.2	-	0	150																											TACCAATAAAGGGTTACATGA	0.547000													25	60					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186459485	186459485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186459485G>A	ENST00000265023.4	+	10	1512	c.1300G>A	c.(1300-1302)Gaa>Aaa	p.E434K	RP11-573D15.8_ENST00000354642.2_RNA|RP11-573D15.8_ENST00000599314.1_RNA|KNG1_ENST00000447445.1_Intron|KNG1_ENST00000287611.2_Intron	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	434	His-rich.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CTGGGGCCATGAAAAACAAAG	0.493000													20	54					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67577114	67577114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67577114C>T	ENST00000540839.3	+	14	2705	c.2485C>T	c.(2485-2487)Cct>Tct	p.P829S	FAM65A_ENST00000422602.2_Missense_Mutation_p.P829S|FAM65A_ENST00000379312.3_Missense_Mutation_p.P813S|FAM65A_ENST00000428437.2_Missense_Mutation_p.P823S|FAM65A_ENST00000042381.4_Missense_Mutation_p.P809S			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	813						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		TGGCCAGTTTCCTGAGCTGCA	0.672000													8	9					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2062038	2062038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2062038G>A	ENST00000280665.6	-	7	1147	c.1068C>T	c.(1066-1068)ttC>ttT	p.F356F	DCP1B_ENST00000540622.1_Silent_p.F230F|DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000397173.4_Silent_p.F254F	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	356					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.F356F(1)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			GAAGTTTCTCGAACAGGTTCT	0.532000													20	77					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36933525	36933525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36933525G>A	ENST00000373103.1	-	14	2309	c.1762C>T	c.(1762-1764)Cat>Tat	p.H588Y	CSF3R_ENST00000338937.5_Missense_Mutation_p.H588Y|CSF3R_ENST00000373106.1_Missense_Mutation_p.H588Y|CSF3R_ENST00000361632.4_Missense_Mutation_p.H588Y|CSF3R_ENST00000373104.1_Missense_Mutation_p.H588Y|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000440588.2_Missense_Mutation_p.H588Y|CSF3R_ENST00000418048.2_Missense_Mutation_p.H588Y|CSF3R_ENST00000331941.5_Missense_Mutation_p.H588Y	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	588	Fibronectin type-III 5.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TCCAGGCCATGGAGGACAAAG	0.627000													6	61					0	0	1	0	0
PUS10	150962	broad.mit.edu	37	2	61233692	61233692	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:61233692C>T	ENST00000316752.6	-	4	729	c.468_splice	c.e4+1	p.E156_splice	PUS10_ENST00000407787.1_Splice_Site_p.E156_splice	NM_144709.2	NP_653310.2	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	156					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)	22			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			ATGACCTTACCTCTCTTACAG	0.373000													5	70					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121981017	121981017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121981017G>A	ENST00000498619.1	+	4	1573	c.1135G>A	c.(1135-1137)Gaa>Aaa	p.E379K	CASR_ENST00000296154.5_Missense_Mutation_p.E379K|CASR_ENST00000490131.1_Missense_Mutation_p.E379K	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	379					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGGTCACGAAGAAAGTGGCGA	0.493000													27	54					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32927476	32927476	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:32927476G>A	ENST00000383763.4	+	3	1134	c.1071G>A	c.(1069-1071)gcG>gcA	p.A357A		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	357					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGATGAAGGCGAAGGTTGTGC	0.552000													31	57					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69816910	69816910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69816910G>A	ENST00000251566.4	-	1	599	c.569C>T	c.(568-570)tCc>tTc	p.S190F	UGT2A3_ENST00000420231.2_5'UTR	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	190						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGGTACATAGGAAAGTGGAGC	0.438000													21	48					0	0	1	0	0
KIAA0368	23392	broad.mit.edu	37	9	114145514	114145514	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114145514G>A	ENST00000259335.4	-	36	4313	c.4314C>T	c.(4312-4314)acC>acT	p.T1438T	KIAA0368_ENST00000338205.5_Silent_p.T1260T|KIAA0368_ENST00000374378.3_5'UTR	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						CTTCCGTCACGGTGCTCATCA	0.483000													10	13					0	0	1	0	0
SMAD5	4090	broad.mit.edu	37	5	135513139	135513139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135513139C>T	ENST00000545279.1	+	9	1726	c.1366C>T	c.(1366-1368)Cct>Tct	p.P456S	SMAD5_ENST00000545620.1_Missense_Mutation_p.P456S|SMAD5_ENST00000514641.2_3'UTR	NM_001001419.1|NM_005903.5	NP_001001419.1|NP_005894.3	Q99717	SMAD5_HUMAN	SMAD family member 5	457	MH2.				BMP signaling pathway|embryonic pattern specification|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			central_nervous_system(1)|large_intestine(4)|lung(3)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GATGGGCTCCCCTCTGAACCC	0.398000													7	22					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219300	67219300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67219300C>T	ENST00000312457.2	-	1	900	c.896G>A	c.(895-897)aGt>aAt	p.S299N		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	299						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GAGGTCGGCACTGGCCATGAG	0.657000													11	78					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563712	176563712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176563712G>A	ENST00000367662.3	+	3	2136	c.972G>A	c.(970-972)ggG>ggA	p.G324G	PAPPA2_ENST00000367661.3_Silent_p.G324G	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	324					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGGCCCTGGGGATCCGCTCAG	0.532000													10	68					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122114506	122114506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122114506G>A	ENST00000334010.7	-	12	2351	c.1930C>T	c.(1930-1932)Cat>Tat	p.H644Y	CADPS2_ENST00000313070.7_Missense_Mutation_p.H640Y|CADPS2_ENST00000449022.2_Missense_Mutation_p.H643Y|CADPS2_ENST00000412584.2_Missense_Mutation_p.H640Y	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	643					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						AGGAAGGCATGATCAAGCTTG	0.393000													25	46					0	0	1	0	0
ASAH2B	653308	broad.mit.edu	37	10	52502754	52502754	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52502754C>T	ENST00000374006.1	+	2	135	c.70C>T	c.(70-72)Cta>Tta	p.L24L	ASAH2B_ENST00000185907.9_5'UTR|ASAH2B_ENST00000483649.1_3'UTR|ASAH2B_ENST00000374007.1_5'UTR	NM_001079516.1	NP_001072984.1	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B	639					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(2)|lung(2)	4						AGAAACCTTGCTAAGGCTATT	0.483000													15	166					0	0	1	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764587	140764587	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140764587C>T	ENST00000518325.1	+	1	2121	c.2121C>T	c.(2119-2121)ttC>ttT	p.F707F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTAGCCTTCGTCCTCGTAC	0.627000													28	69					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55174728	55174728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55174728C>T	ENST00000414150.2	+	23	3987	c.3709C>T	c.(3709-3711)Cgt>Tgt	p.R1237C	MROH7_ENST00000409996.1_Missense_Mutation_p.R805C|MROH7_ENST00000454855.2_Missense_Mutation_p.R755C|MROH7_ENST00000421030.2_Missense_Mutation_p.R1237C					maestro heat-like repeat family member 7																		GACAGAAGATCGTCTGAATGA	0.517000													25	78					0	0	1	0	0
CCDC69	26112	broad.mit.edu	37	5	150578630	150578630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150578630C>T	ENST00000355417.2	-	4	421	c.247G>A	c.(247-249)Gag>Aag	p.E83K	CCDC69_ENST00000521308.1_5'UTR	NM_015621.2	NP_056436.2	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69	83										haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|stomach(1)	9		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCTCTAGCTCCCTTTCCTTC	0.557000													45	127					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32810233	32810233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32810233C>T	ENST00000380250.3	+	43	6230	c.5734C>T	c.(5734-5736)Ctc>Ttc	p.L1912F		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1912					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AATGGAAGCGCTCCTAACCTT	0.388000													12	50					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6484041	6484041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6484041G>A	ENST00000263125.5	-	16	1749	c.1650C>T	c.(1648-1650)atC>atT	p.I550I	PRKCQ_ENST00000539722.1_Silent_p.I425I|PRKCQ_ENST00000397176.2_Intron	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	550	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						GACCCAGCAAGATCTGCACAA	0.507000													11	45					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189455532	189455532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189455532C>T	ENST00000264731.3	+	2	155	c.66C>T	c.(64-66)ttC>ttT	p.F22F	TP63_ENST00000418709.2_Silent_p.F22F|TP63_ENST00000320472.5_Silent_p.F22F|TP63_ENST00000392460.3_Silent_p.F22F|TP63_ENST00000382063.4_Silent_p.F22F|TP63_ENST00000440651.2_Silent_p.F22F	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	22	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TTTTAAGTTTCGTAGAAACCC	0.348000										HNSCC(45;0.13)			27	96					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75888726	75888726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75888726C>T	ENST00000274364.6	+	9	1180	c.883C>T	c.(883-885)Caa>Taa	p.Q295*	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	295					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGCAGAAATCCAAGGCAATAT	0.358000													56	124					0	0	1	0	0
OGN	4969	broad.mit.edu	37	9	95148533	95148533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95148533C>T	ENST00000262551.4	-	6	1096	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K	CENPP_ENST00000375587.3_Intron|OGN_ENST00000375561.5_Missense_Mutation_p.E226K	NM_033014.2	NP_148935.1	P20774	MIME_HUMAN	osteoglycin	226						extracellular space|proteinaceous extracellular matrix	growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	13						GGCACGGATTCCAGGGCATTA	0.378000													25	75					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234197	21234197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21234197G>A	ENST00000233242.1	-	26	5670	c.5543C>T	c.(5542-5544)tCa>tTa	p.S1848L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1848					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATAGCTTGCTGATAAGGCAGC	0.478000													18	164					0	0	1	0	0
KCNN2	3781	broad.mit.edu	37	5	113698904	113698904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:113698904C>T	ENST00000512097.3	+	2	1450	c.432C>T	c.(430-432)ttC>ttT	p.F144F	KCNN2_ENST00000507750.1_3'UTR|KCNN2_ENST00000264773.3_Silent_p.F144F			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	144						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TCGGCATGTTCGGCATCGTGG	0.612000													9	37					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3547939	3547939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3547939C>T	ENST00000355415.2	-	4	913	c.744G>A	c.(742-744)gaG>gaA	p.E248E	MFSD12_ENST00000389395.3_Silent_p.E248E|MFSD12_ENST00000591878.1_5'UTR|MFSD12_ENST00000398558.4_Silent_p.E248E|AC005786.7_ENST00000589360.1_RNA	NM_174983.3	NP_778148.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	248					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						CGCCTGGCTCCTCCGCATGCG	0.697000													7	17					0	0	1	0	0
CCM2L	140706	broad.mit.edu	37	20	30617636	30617636	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30617636T>A	ENST00000300415.8	+	9	1410	c.1397T>A	c.(1396-1398)cTc>cAc	p.L466H	RP1-310O13.7_ENST00000449519.1_RNA|CCM2L_ENST00000262659.8_3'UTR					cerebral cavernous malformation 2-like																		AAGTTCCTCCTCCTTGGTGAG	0.612000													8	49					0	0	1	0	0
PRKAR2B	5577	broad.mit.edu	37	7	106710741	106710741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:106710741G>A	ENST00000265717.4	+	2	582	c.323G>A	c.(322-324)cGa>cAa	p.R108Q	PRKAR2B_ENST00000393613.2_3'UTR	NM_002736.2	NP_002727.2	P31323	KAP3_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, beta	108	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	14						GTAATAAACCGATTCACAAGG	0.313000													26	74					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222493	140222493	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140222493G>A	ENST00000531613.1	+	1	1587	c.1587G>A	c.(1585-1587)gaG>gaA	p.E529E	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Silent_p.E529E|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGCTAGAGCTGCTGCAGT	0.677000													69	39					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54577320	54577320	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54577320G>A	ENST00000251636.5	-	12	2137	c.1989C>T	c.(1987-1989)atC>atT	p.I663I	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	663	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				ATTCCATCCGGATCTGATATC	0.393000													23	98					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880394	74880394	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74880394T>C	ENST00000289575.5	+	5	1020	c.625T>C	c.(625-627)Ttt>Ctt	p.F209L	SLCO2B1_ENST00000532236.1_Missense_Mutation_p.F93L|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.F65L|SLCO2B1_ENST00000526660.1_Intron|SLCO2B1_ENST00000341411.4_Intron|SLCO2B1_ENST00000454962.2_Intron|SLCO2B1_ENST00000531756.1_Intron|SLCO2B1_ENST00000428359.2_Missense_Mutation_p.F187L	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	209					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	CATTCAGCCCTTTGGCATCTC	0.597000													22	78					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656113	40656113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:40656113C>T	ENST00000406785.1	-	2	1497	c.1308G>A	c.(1306-1308)ttG>ttA	p.L436L	SLC8A1_ENST00000542024.1_Silent_p.L436L|SLC8A1_ENST00000542756.1_Silent_p.L436L|SLC8A1_ENST00000332839.4_Silent_p.L436L|SLC8A1_ENST00000405901.3_Silent_p.L436L|SLC8A1_ENST00000403092.1_Silent_p.L436L|SLC8A1_ENST00000405269.1_Silent_p.L436L|SLC8A1_ENST00000402441.1_Silent_p.L436L|SLC8A1_ENST00000408028.2_Silent_p.L436L|SLC8A1_ENST00000406391.2_Silent_p.L436L			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	436	Calx-beta 1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CAGTGTTAGTCAAATCACCAC	0.443000													26	79					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145006619	145006619	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145006619G>A	ENST00000322810.4	-	16	2506	c.2337C>T	c.(2335-2337)ttC>ttT	p.F779F	PLEC_ENST00000356346.3_Silent_p.F628F|PLEC_ENST00000357649.2_Silent_p.F646F|PLEC_ENST00000436759.2_Silent_p.F669F|PLEC_ENST00000527096.1_Silent_p.F665F|PLEC_ENST00000398774.2_Silent_p.F610F|PLEC_ENST00000345136.3_Silent_p.F642F|PLEC_ENST00000354589.3_Silent_p.F642F|PLEC_ENST00000354958.2_Silent_p.F620F	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	779	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGCTCCAGTCGAAGCCCACCT	0.632000													24	64					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	394645	394645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:394645G>A	ENST00000280886.6	-	26	3254	c.3167C>T	c.(3166-3168)aCc>aTc	p.T1056I		NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	1056						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGACGGACGGTTATTGGCAC	0.547000													59	163					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19498517	19498517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19498517C>T	ENST00000396229.2	+	17	3191	c.2442C>T	c.(2440-2442)atC>atT	p.I814I	TMC5_ENST00000219821.5_Silent_p.I568I|TMC5_ENST00000542583.2_Silent_p.I814I|CTA-363E6.6_ENST00000561762.1_RNA|TMC5_ENST00000541464.1_Silent_p.I762I|TMC5_ENST00000381414.4_Silent_p.I814I|TMC5_ENST00000561503.1_Silent_p.I455I|TMC5_ENST00000564959.1_Silent_p.I497I	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	814						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CTCTTCAGATCAGCCTGATGA	0.587000													15	49					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39247056	39247056	+	Silent	SNP	C	C	T	rs142566948		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:39247056C>T	ENST00000518318.2	+	4	390	c.348C>T	c.(346-348)gcC>gcT	p.A116A	POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_Silent_p.A116A|POU6F2_ENST00000559001.1_Silent_p.A108A			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	116					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						GCCCCCCAGCCCTCAACCAGC	0.577000													58	157					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55339669	55339669	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55339669G>A	ENST00000314634.3	+	1	66	c.66G>A	c.(64-66)aaG>aaA	p.K22K		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				CTTTTTGGAAGAAAATAGTGT	0.398000													18	139					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501772	90501772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90501772C>T	ENST00000325643.5	+	4	2436	c.2370C>T	c.(2368-2370)ctC>ctT	p.L790L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCTCCTGGCTCATGGCCAAAT	0.577000													6	65					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149227972	149227972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:149227972C>T	ENST00000407073.1	+	9	3457	c.2460C>T	c.(2458-2460)tcC>tcT	p.S820S	MBD5_ENST00000404807.1_Silent_p.S820S	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	820						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CAACGTCCTCCACTCCAGTGA	0.428000													27	90					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28149675	28149675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28149675G>A	ENST00000305242.5	-	19	2992	c.2900C>T	c.(2899-2901)cCa>cTa	p.P967L	ARMC4_ENST00000537576.1_Missense_Mutation_p.P659L|ARMC4_ENST00000545014.1_Missense_Mutation_p.P492L	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	967							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						ACGCACTAGTGGAGCCACTGC	0.478000													27	66					0	0	1	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124229290	124229290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124229290C>T	ENST00000330342.3	+	12	1721	c.1473C>T	c.(1471-1473)tcC>tcT	p.S491S		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	491					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		TGTACAGCTCCAGCCACCCAC	0.527000													22	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068061	9068061	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9068061C>T	ENST00000397910.4	-	3	19588	c.19385G>A	c.(19384-19386)tGg>tAg	p.W6462*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6464	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATGTGTCCCAGGTAAGGGT	0.483000													54	137					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94945194	94945194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94945194C>T	ENST00000357742.4	+	16	2031	c.2031C>T	c.(2029-2031)ttC>ttT	p.F677F	MCTP2_ENST00000557742.1_Silent_p.F265F|MCTP2_ENST00000451018.3_Silent_p.F677F|MCTP2_ENST00000331706.4_Silent_p.F265F	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	677					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CAATGCAGTTCCTTAAAAGCT	0.353000													21	121					0	0	1	0	0
COLEC12	81035	broad.mit.edu	37	18	346892	346892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:346892G>A	ENST00000400256.3	-	5	937	c.730C>T	c.(730-732)Ctg>Ttg	p.L244L		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	244					carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				ACCTGCTGCAGATTTTGAAAG	0.527000													28	85					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179666962	179666962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179666962C>T	ENST00000589042.1	-	3	422	c.198G>A	c.(196-198)acG>acA	p.T66T	TTN_ENST00000342992.6_Silent_p.T66T|TTN_ENST00000360870.5_Silent_p.T66T|TTN_ENST00000591111.1_Silent_p.T66T|TTN_ENST00000342175.6_Silent_p.T66T|TTN_ENST00000359218.5_Silent_p.T66T|TTN_ENST00000460472.2_Silent_p.T66T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	66	Ig-like 1.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGCGGGGATCGTCAGTTTAG	0.542000													31	84					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447371	226447371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:226447371C>T	ENST00000272907.6	+	4	1651	c.1238C>T	c.(1237-1239)tCg>tTg	p.S413L	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	413	Pro-rich.																CTCTCCTCGTCGCCCCCACCC	0.682000													5	15					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132527047	132527047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:132527047G>A	ENST00000331898.7	-	2	913	c.335C>T	c.(334-336)cCg>cTg	p.P112L	OPCML_ENST00000374778.4_Missense_Mutation_p.P71L|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000524381.1_Missense_Mutation_p.P105L|OPCML_ENST00000541867.1_Missense_Mutation_p.P112L	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	112	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity	p.P112L(1)		endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GCAGGTGTACGGACCTTCGTC	0.502000													22	89					0	0	1	0	0
NRG4	145957	broad.mit.edu	37	15	76254290	76254290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:76254290G>A	ENST00000394907.3	-	4	311	c.130C>T	c.(130-132)Cgt>Tgt	p.R44C	NRG4_ENST00000535975.1_Missense_Mutation_p.R44C	NM_138573.3	NP_612640.1	Q8WWG1	NRG4_HUMAN	neuregulin 4	44	EGF-like.					extracellular region|integral to membrane|plasma membrane	growth factor activity			large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5						TCTTCACAACGAGCTCCTGTA	0.388000													73	85					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29642577	29642577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:29642577C>T	ENST00000373779.3	+	24	3556	c.3427C>T	c.(3427-3429)Cct>Tct	p.P1143S	PTPRU_ENST00000428026.2_Missense_Mutation_p.P1140S|PTPRU_ENST00000460170.2_Missense_Mutation_p.P1149S|PTPRU_ENST00000323874.8_Missense_Mutation_p.P1149S|PTPRU_ENST00000345512.3_Missense_Mutation_p.P1153S|PTPRU_ENST00000356870.3_Missense_Mutation_p.P1149S	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1153	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GACCACCATCCCTGTCAGTGA	0.557000													18	58					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43634857	43634857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43634857C>T	ENST00000360835.3	-	7	957	c.831G>A	c.(829-831)ggG>ggA	p.G277G	Z82214.2_ENST00000419643.1_RNA|SCUBE1_ENST00000290460.7_Silent_p.G307G	NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	277	EGF-like 5 (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				TGCATGTCTTCCCGTCCGGCT	0.637000													8	48					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159650951	159650951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159650951G>A	ENST00000297267.9	+	10	1485	c.1285G>A	c.(1285-1287)Gaa>Aaa	p.E429K	FNDC1_ENST00000340366.6_Intron	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	429	Fibronectin type-III 4.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCAGCCTGGGGAACGCTATCT	0.517000													108	137					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834543	101834543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101834543G>A	ENST00000506729.1	-	1	177	c.6C>T	c.(4-6)ttC>ttT	p.F2F	SLCO6A1_ENST00000379807.3_Silent_p.F2F|SLCO6A1_ENST00000379810.1_Silent_p.F2F|SLCO6A1_ENST00000389019.3_Silent_p.F2F|SLCO6A1_ENST00000513675.1_Silent_p.F2F			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	2						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CGACGCCTACGAACATGGCTC	0.711000													62	137					0	0	1	0	0
C1QB	713	broad.mit.edu	37	1	22987444	22987444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22987444C>T	ENST00000509305.1	+	3	667	c.321C>T	c.(319-321)ccC>ccT	p.P107P	C1QB_ENST00000314933.6_Silent_p.P109P			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	109	Collagen-like 2.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCCCAGGCCCCAAAGGTGAAT	0.632000													20	65					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110737331	110737331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110737331C>T	ENST00000331565.4	+	9	1915	c.1430C>T	c.(1429-1431)aCc>aTc	p.T477I	SLC6A17_ENST00000465159.1_3'UTR	NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	477					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		ATGATCGGGACCATGGCAGGC	0.602000													14	58					0	0	1	0	0
PRSS3	5646	broad.mit.edu	37	9	33796705	33796705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33796705C>T	ENST00000361005.5	+	2	276	c.276C>T	c.(274-276)ctC>ctT	p.L92L	RP11-133O22.6_ENST00000454429.2_RNA|PRSS3_ENST00000429677.3_Silent_p.L28L|PRSS3_ENST00000342836.4_Silent_p.L49L|PRSS3_ENST00000379405.3_Silent_p.L35L	NM_007343.3	NP_031369.2	P35030	TRY3_HUMAN	protease, serine, 3	92	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity			large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	13			LUSC - Lung squamous cell carcinoma(29;0.0176)			AGAATTCTCTCCCCTACCAGG	0.532000													10	176					0	0	1	0	0
LRRC57	255252	broad.mit.edu	37	15	42837368	42837368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42837368C>T	ENST00000323443.2	-	4	952	c.585G>A	c.(583-585)caG>caA	p.Q195Q	LRRC57_ENST00000397130.3_Silent_p.Q195Q|LRRC57_ENST00000563454.1_Silent_p.Q195Q			Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	195										breast(1)|kidney(1)|lung(5)|prostate(1)	8		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		TGAGGATGCTCTGGGGAAGCA	0.423000													36	83					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38753715	38753715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38753715G>A	ENST00000449082.2	-	22	4025	c.4026C>T	c.(4024-4026)ttC>ttT	p.F1342F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1342					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CATTGACCCAGAAGAAGCTGC	0.428000													44	109					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18062264	18062264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18062264G>A	ENST00000205890.5	+	53	9447	c.9109G>A	c.(9109-9111)Gag>Aag	p.E3037K	MYO15A_ENST00000418233.3_Missense_Mutation_p.E301K	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	3037	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					GAAATCCAAGGAGCCTCGGGA	0.562000													13	35					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141051219	141051219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141051219C>T	ENST00000239440.4	-	12	1837	c.1772G>A	c.(1771-1773)gGa>gAa	p.G591E	ARAP3_ENST00000513878.1_Missense_Mutation_p.G253E|ARAP3_ENST00000508305.1_Missense_Mutation_p.G513E	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	591	Arf-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GATGAACTCTCCCCGGGGGCC	0.592000													14	48					0	0	1	0	0
SLC35C1	55343	broad.mit.edu	37	11	45832766	45832766	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:45832766G>A	ENST00000314134.3	+	2	2371	c.975G>A	c.(973-975)acG>acA	p.T325T	SLC35C1_ENST00000442528.2_Silent_p.T312T|SLC35C1_ENST00000456334.1_Silent_p.T312T	NM_018389.4	NP_060859.4	Q96A29	FUCT1_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C1	325						Golgi membrane|integral to membrane	GDP-fucose transmembrane transporter activity			endometrium(3)|kidney(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				GBM - Glioblastoma multiforme(35;0.227)		TCTGGTGGACGAGCAACATGA	0.632000													22	16					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55196641	55196641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55196641G>A	ENST00000340465.2	+	2	237	c.151G>A	c.(151-153)Gat>Aat	p.D51N		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	51						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TGCCTGCAATGATTCAGGTAA	0.318000													11	31					0	0	1	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086784	46086784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46086784G>A	ENST00000360770.3	-	1	60	c.20C>T	c.(19-21)tCc>tTc	p.S7F	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	7						keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						GCAGCCCGAGGAGCAGCTGGT	0.667000													9	16					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21069001	21069001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21069001C>T	ENST00000381545.3	+	16	2148	c.1929C>T	c.(1927-1929)ttC>ttT	p.F643F	SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000540229.1_Intron|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Silent_p.F643F|SLCO1B3_ENST00000553473.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	643					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATATTGTTTTCATTTTTGCTA	0.303000													15	45					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158609381	158609381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158609381C>T	ENST00000368148.3	-	35	5151	c.4971G>A	c.(4969-4971)ttG>ttA	p.L1657L	SPTA1_ENST00000368147.3_Silent_p.L1657L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1657					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCTCTCGAGCCAACATCTCTC	0.483000													20	120					0	0	1	0	0
SALL4	57167	broad.mit.edu	37	20	50401220	50401220	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50401220G>A	ENST00000217086.4	-	4	2857	c.2746C>T	c.(2746-2748)Cac>Tac	p.H916Y	SALL4_ENST00000371539.3_Missense_Mutation_p.H139Y|SALL4_ENST00000395997.3_Missense_Mutation_p.H479Y	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	916					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTCATGTAGTGAACCTATGGG	0.468000													19	64					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768403	117768403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117768403C>T	ENST00000317775.6	-	2	1157	c.472G>A	c.(472-474)Ggg>Agg	p.G158R	NOS1_ENST00000344089.3_Missense_Mutation_p.G158R|NOS1_ENST00000338101.4_Missense_Mutation_p.G158R	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	158	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGCTGAGGCCCATTCCCGGGA	0.701000													20	93					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205042351	205042351	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205042351C>T	ENST00000331830.4	+	22	3284	c.3000C>T	c.(2998-3000)atC>atT	p.I1000I		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	1000	Fibronectin type-III 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAGTCCACATCGTGAGGAATG	0.567000													22	64					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58701016	58701016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58701016C>T	ENST00000305921.3	+	2	839	c.607C>T	c.(607-609)Ccg>Tcg	p.P203S		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	203	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			TCAGGATGACCCGAAGGATGA	0.507000													49	92					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74364604	74364604	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74364604C>T	ENST00000290438.3	-	14	1588	c.1548G>A	c.(1546-1548)cgG>cgA	p.R516R		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	516										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						TTGGCGTGGGCCGAGGCGCCT	0.632000													17	175					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48261760	48261760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48261760G>A	ENST00000394747.1	-	3	701	c.352C>T	c.(352-354)Cct>Tct	p.P118S	ABCC11_ENST00000394748.1_Missense_Mutation_p.P118S|ABCC11_ENST00000353782.5_Missense_Mutation_p.P118S|ABCC11_ENST00000537808.1_Missense_Mutation_p.P118S|ABCC11_ENST00000356608.2_Missense_Mutation_p.P118S	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	118						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GACAGTGGAGGGATGGTGTTC	0.522000													44	128					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125083791	125083791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125083791G>A	ENST00000522917.1	+	31	4217	c.4011G>A	c.(4009-4011)gaG>gaA	p.E1337E	FER1L6_ENST00000399018.1_Silent_p.E1337E|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1337						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTAGCTCTGAGGACAGCGGGC	0.512000													16	39					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52565264	52565264	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52565264T>G	ENST00000394815.2	-	9	1374	c.1277A>C	c.(1276-1278)aAg>aCg	p.K426T	KRT80_ENST00000313234.5_3'UTR	NM_182507.2	NP_872313.2	Q6KB66	K2C80_HUMAN	keratin 80	426	Tail.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		GCTGCCCTTCTTCTTTCGGGA	0.577000													21	52					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15881966	15881966	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15881966G>A	ENST00000587443.2	-	0	931					NR_033864.1																						CGTCATGGGAGAGGTAATACA	0.557000													30	72					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31284752	31284752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31284752G>A	ENST00000544665.3	+	8	842	c.771G>A	c.(769-771)acG>acA	p.T257T	ITGAM_ENST00000287497.8_Silent_p.T257T	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	257	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TTGTCATCACGGATGGAGAAA	0.498000													36	54					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86965435	86965435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86965435G>A	ENST00000234701.3	+	15	2803	c.2452G>A	c.(2452-2454)Gaa>Aaa	p.E818K	CLCA1_ENST00000394711.1_Missense_Mutation_p.E818K			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	818					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CATCCCAAAGGAAGCCAACTC	0.363000													37	160					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487739	248487739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248487739G>A	ENST00000317965.2	-	1	160	c.132C>T	c.(130-132)atC>atT	p.I44I		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGAGAACCATGATGGAGTTTC	0.532000													113	324					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84270886	84270886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84270886C>T	ENST00000568181.1	-	2	326	c.206G>A	c.(205-207)aGg>aAg	p.R69K	KCNG4_ENST00000308251.4_Missense_Mutation_p.R69K			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	69						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GAGGAGATACCTCCTGCCCCC	0.622000													13	80					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	39966859	39966859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39966859C>T	ENST00000336649.4	+	1	102	c.102C>T	c.(100-102)tcC>tcT	p.S34S	CACNA1I_ENST00000407673.1_Silent_p.S34S|CACNA1I_ENST00000404898.1_Silent_p.S34S|CACNA1I_ENST00000402142.3_Silent_p.S34S|CACNA1I_ENST00000401624.1_Silent_p.S34S|CACNA1I_ENST00000400164.3_Silent_p.S34S			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	34					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCCCATCCTCCCCGCCAGGCC	0.687000													11	34					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102250605	102250605	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102250605G>A	ENST00000370345.3	-	20	2605	c.2508C>T	c.(2506-2508)acC>acT	p.T836T		NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	836	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		ATGACTGAGGGGTGAAAACCC	0.488000													10	54					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271387	22271387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22271387C>T	ENST00000594947.1	+	4	979	c.835C>T	c.(835-837)Cat>Tat	p.H279Y		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAGAGAATTCATAATAGAGA	0.378000													14	38					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42821976	42821976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42821976G>A	ENST00000598766.1	+	12	1088	c.1088G>A	c.(1087-1089)cGa>cAa	p.R363Q	TMEM145_ENST00000301204.3_Missense_Mutation_p.R339Q			Q8NBT3	TM145_HUMAN	transmembrane protein 145	339						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				GTCTCACTGCGACACTTTCCT	0.582000													8	122					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794845	126794845	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126794845C>T	ENST00000373615.4	+	5	1819	c.1080C>T	c.(1078-1080)ccC>ccT	p.P360P		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	360						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						CGCTCAGCCCCTCCAGCACGC	0.657000													14	37					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14752664	14752664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14752664G>A	ENST00000358984.4	+	2	501	c.321G>A	c.(319-321)agG>agA	p.R107R	ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Silent_p.R107R	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	107										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						GCGAAGGGAGGACACCTCTGA	0.413000													3	8					0	0	1	0	0
UPB1	51733	broad.mit.edu	37	22	24898487	24898487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24898487C>T	ENST00000382760.2	+	4	709	c.547C>T	c.(547-549)Cct>Tct	p.P183S	UPB1_ENST00000413389.2_Intron|UPB1_ENST00000326010.5_Intron			Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	0	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					cagctggtctcctgtgccctc	0.527000													42	93					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	67726390	67726390	+	Missense_Mutation	SNP	C	C	T	rs145119798	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:67726390C>T	ENST00000433211.1	-	17	2554	c.2380G>A	c.(2380-2382)Gga>Aga	p.G794R	CTNNA3_ENST00000373735.1_Missense_Mutation_p.G133R|CTNNA3_ENST00000373744.4_Missense_Mutation_p.G794R	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	794					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						ATGAGCTCTCCTCCCAGGTTC	0.448000													37	94					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800953	185800953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185800953C>T	ENST00000302277.6	+	4	1424	c.830C>T	c.(829-831)tCt>tTt	p.S277F		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	277						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAAACTAACTCTTTTCATCCA	0.368000													20	93					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74714335	74714335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74714335G>A	ENST00000373032.3	-	1	201	c.109C>T	c.(109-111)Cgg>Tgg	p.R37W		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	37					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					CGGAGGTGCCGAAGGCCCCAG	0.572000													64	157					0	0	1	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874201	31874201	+	Missense_Mutation	SNP	C	C	T	rs73186218	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31874201C>T	ENST00000334151.2	-	1	234	c.208G>A	c.(208-210)Gga>Aga	p.G70R		NM_181611.1	NP_853642.1	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	70						intermediate filament	protein binding			endometrium(1)|large_intestine(5)|lung(4)|pancreas(1)|prostate(1)	12						CAATAAAATCCAGAGAATCCA	0.502000													41	124					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159922231	159922231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159922231C>T	ENST00000368093.3	-	3	601	c.485G>A	c.(484-486)gGc>gAc	p.G162D	SLAMF9_ENST00000368092.3_Intron|SLAMF9_ENST00000466773.1_5'UTR	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	162	Ig-like C2-type.					integral to membrane		p.G162D(1)		breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATATCCATGCCTGCCTTCTC	0.577000													65	98					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915014	119915014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:119915014G>A	ENST00000331113.4	+	1	1293	c.328G>A	c.(328-330)Gag>Aag	p.E110K		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	110					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TCCTCGCCACGAGTGCATCTC	0.527000													53	199					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71576875	71576875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71576875C>T	ENST00000409544.1	+	2	1421	c.791C>T	c.(790-792)cCt>cTt	p.P264L	ZNF638_ENST00000377802.2_Missense_Mutation_p.P264L|ZNF638_ENST00000355812.3_Missense_Mutation_p.P264L|ZNF638_ENST00000264447.4_Missense_Mutation_p.P264L|ZNF638_ENST00000410075.1_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	264					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TCTATGTTTCCTGTTGAAGAC	0.428000													58	147					0	0	1	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30951447	30951447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30951447G>A	ENST00000402321.1	-	3	1082	c.765C>T	c.(763-765)ttC>ttT	p.F255F	GAL3ST1_ENST00000338911.5_Silent_p.F255F|GAL3ST1_ENST00000443111.2_Silent_p.F255F|GAL3ST1_ENST00000406955.1_Silent_p.F255F|GAL3ST1_ENST00000401975.1_Silent_p.F255F|GAL3ST1_ENST00000402369.1_Silent_p.F255F|GAL3ST1_ENST00000406361.1_Silent_p.F255F			Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	255					protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity	p.F255F(1)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21						GCGACTCGTCGAAGTACTCTT	0.647000													30	112					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543009	28543009	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28543009G>A	ENST00000452236.2	-	3	2090	c.1473C>T	c.(1471-1473)aaC>aaT	p.N491N		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	491	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						AGTGTGATGAGTTGTTAGTTT	0.433000													48	104					0	0	1	0	0
FRMD1	79981	broad.mit.edu	37	6	168479715	168479715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:168479715G>A	ENST00000283309.6	-	1	124	c.60C>T	c.(58-60)ttC>ttT	p.F20F		NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	20						cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CTGAAGGAGGGAACGTGTCAG	0.662000													15	37					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205899140	205899140	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205899140G>A	ENST00000367135.3	-	6	710	c.597C>T	c.(595-597)ctC>ctT	p.L199L	SLC26A9_ENST00000367134.2_Silent_p.L199L|SLC26A9_ENST00000340781.4_Silent_p.L199L	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	199						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGGACTCGGAGAGGTAGATGG	0.567000													12	37					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62855787	62855787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62855787G>A	ENST00000584306.1	-	11	5007	c.4477C>T	c.(4477-4479)Ctc>Ttc	p.L1493F	LRRC37A3_ENST00000339474.5_Missense_Mutation_p.L611F|LRRC37A3_ENST00000334962.5_Missense_Mutation_p.L470F|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.L1493F|LRRC37A3_ENST00000400877.3_Missense_Mutation_p.L531F	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1493						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TGAGCAATGAGCCTTCTCACA	0.517000													103	366					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110489988	110489988	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:110489988C>T	ENST00000324068.1	-	13	1911		c.e13-1		CAPN6_ENST00000541758.1_Splice_Site	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6						microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						TGTTCCAGACCTGGAAAGACA	0.493000													25	11					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73486830	73486830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73486830C>T	ENST00000314256.7	+	11	1513	c.1119C>T	c.(1117-1119)gtC>gtT	p.V373V	KIAA0195_ENST00000579208.1_Silent_p.V24V|KIAA0195_ENST00000375248.5_Silent_p.V383V	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	373					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGGAGGCTGTCTCCTCTCAGG	0.557000													15	37					0	0	1	0	0
CFHR2	3080	broad.mit.edu	37	1	196928210	196928210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196928210G>A	ENST00000367415.4	+	5	927	c.813G>A	c.(811-813)taG>taA	p.*271*	CFHR2_ENST00000367421.3_Silent_p.*271*	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	0						extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						AAGAAAAATAGAATCAATGGC	0.284000													14	59					0	0	1	0	0
OR13C9	286362	broad.mit.edu	37	9	107379817	107379817	+	Silent	SNP	G	G	A	rs74950199		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107379817G>A	ENST00000259362.1	-	1	668	c.669C>T	c.(667-669)tcC>tcT	p.S223S		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						TGAGGATGCTGGAAATGATTA	0.443000													37	66					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72176258	72176258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:72176258G>A	ENST00000555818.1	+	15	4496	c.4148G>A	c.(4147-4149)gGc>gAc	p.G1383D	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.G1362D|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.G1362D|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.G837D	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1383	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAGAGCCACGGCCTGGACCGG	0.562000													20	42					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107748257	107748257	+	Missense_Mutation	SNP	C	C	T	rs147178647		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107748257C>T	ENST00000388781.3	-	6	493	c.410G>A	c.(409-411)cGg>cAg	p.R137Q	LAMB4_ENST00000205386.4_Missense_Mutation_p.R137Q|LAMB4_ENST00000414450.2_Missense_Mutation_p.R137Q|LAMB4_ENST00000388780.3_Missense_Mutation_p.R137Q	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	137	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TGCAGCAGGCCGAAAAGTCTA	0.348000													21	40					0	0	1	0	0
ING3	54556	broad.mit.edu	37	7	120609222	120609222	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120609222C>T	ENST00000315870.5	+	9	1020	c.872C>T	c.(871-873)tCa>tTa	p.S291L	ING3_ENST00000431467.1_Missense_Mutation_p.S276L	NM_019071.2	NP_061944.2	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3	291					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			NS(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	12	all_neural(327;0.117)					AATGCCAGTTCATCAGCAGCC	0.418000													24	69					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10089688	10089688	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10089688C>T	ENST00000287647.3	+	16	1459	c.1366C>T	c.(1366-1368)Ctc>Ttc	p.L456F	FANCD2_ENST00000383807.1_Missense_Mutation_p.L456F|FANCD2_ENST00000419585.1_Missense_Mutation_p.L456F|FANCD2_ENST00000383806.1_Missense_Mutation_p.L456F	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	456			L -> R (in dbSNP:rs35782247).		DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ATTTGGCAGTCTCCTATACAA	0.393000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				14	225					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24442218	24442218	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:24442218C>T	ENST00000383168.4	-	2	503	c.375G>A	c.(373-375)ggG>ggA	p.G125G	AQP4_ENST00000581374.1_Silent_p.G103G|AQP4-AS1_ENST00000579964.1_RNA|AQP4-AS1_ENST00000582605.1_RNA|AQP4_ENST00000440832.3_Silent_p.G103G	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	125					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					CAATGATGGCCCCCAGGCACT	0.557000													28	67					0	0	1	0	0
CINP	51550	broad.mit.edu	37	14	102816294	102816294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102816294C>T	ENST00000216756.6	-	4	438	c.398G>A	c.(397-399)cGa>cAa	p.R133Q	CINP_ENST00000541568.2_Intron|CINP_ENST00000536961.2_Missense_Mutation_p.R148Q	NM_032630.2	NP_116019.1	Q9BW66	CINP_HUMAN	cyclin-dependent kinase 2 interacting protein	133					cell cycle|cell division|DNA repair|DNA replication	nucleus	protein binding			large_intestine(2)|lung(2)	4						CAGAGGGGGTCGTTTACTCTC	0.413000													20	45					0	0	1	0	0
DEPTOR	64798	broad.mit.edu	37	8	121013894	121013894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121013894C>T	ENST00000286234.5	+	5	865	c.735C>T	c.(733-735)ccC>ccT	p.P245P	DEPTOR_ENST00000523492.1_Silent_p.P144P|DEPTOR_ENST00000518057.1_3'UTR	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	245	Ser-rich.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						ATGACAGTCCCTTCTGCCTGA	0.493000													15	60					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197032181	197032181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197032181G>A	ENST00000367412.1	-	2	114	c.71C>T	c.(70-72)cCc>cTc	p.P24L		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	24	Sushi 1.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						AAAACCACAGGGTTTCTCTGA	0.294000													62	163					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74163761	74163761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74163761G>A	ENST00000269391.6	-	4	546	c.414C>T	c.(412-414)gcC>gcT	p.A138A	RNF157_ENST00000319945.6_Silent_p.A138A	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	138							zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			ACTCTTCCGTGGCCTGGTAAT	0.498000													27	108					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36706717	36706717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:36706717G>A	ENST00000280527.2	+	7	1619	c.1252G>A	c.(1252-1254)Gaa>Aaa	p.E418K		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	418	VWFC 2.				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CCGGTGGCGGGAAGACGACTG	0.552000													7	118					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36149243	36149243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36149243G>A	ENST00000303965.4	-	18	3615	c.3126C>T	c.(3124-3126)tcC>tcT	p.S1042S		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1042	PH 4.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AATGCAAGCTGGATTTGTCCA	0.408000													19	64					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18347479	18347479	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18347479G>A	ENST00000429452.1	-	23	3515	c.3163C>T	c.(3163-3165)Ctg>Ttg	p.L1055L	MICAL3_ENST00000207726.7_Intron|MICAL3_ENST00000400561.2_Intron|MICAL3_ENST00000414725.2_Intron|MICAL3_ENST00000585038.1_Silent_p.L1055L|MICAL3_ENST00000444520.1_Intron|MICAL3_ENST00000383094.3_Intron|MICAL3_ENST00000441493.2_Intron	NM_001136004.1	NP_001129476.1	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	0	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		ACCTCCGACAGGCCATAGAGA	0.587000													7	26					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678498	88678498	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88678498C>T	ENST00000394480.1	-	10	1359	c.1038G>A	c.(1036-1038)aaG>aaA	p.K346K	NTRK3_ENST00000542733.2_Silent_p.K248K|NTRK3_ENST00000355254.2_Silent_p.K346K|NTRK3_ENST00000317501.3_Silent_p.K346K|NTRK3_ENST00000357724.2_Silent_p.K346K|NTRK3_ENST00000540489.2_Silent_p.K346K|NTRK3_ENST00000558676.1_Silent_p.K346K|NTRK3_ENST00000360948.2_Silent_p.K346K|NTRK3_ENST00000557856.1_Silent_p.K346K	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	346	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CATGGATGATCTTGGACTCCC	0.567000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			10	140					0	0	1	0	0
LCE1A	353131	broad.mit.edu	37	1	152800190	152800190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152800190G>A	ENST00000335123.2	+	1	242	c.242G>A	c.(241-243)aGa>aAa	p.R81K		NM_178348.2	NP_848125.1	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	81	Cys-rich.				keratinization					endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	8	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACCGTCACAGACTCCAGAGC	0.697000													19	42					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23237062	23237062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23237062C>T	ENST00000400191.3	+	14	2708	c.2690C>T	c.(2689-2691)tCc>tTc	p.S897F	EPHB2_ENST00000374632.3_Missense_Mutation_p.S898F|EPHB2_ENST00000374630.3_Missense_Mutation_p.S897F|EPHB2_ENST00000374627.1_Missense_Mutation_p.S892F	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	897					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GCGCCCCTCTCCTCTGGGTAA	0.617000													10	30					0	0	1	0	0
MAX	4149	broad.mit.edu	37	14	65550981	65550981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65550981G>A	ENST00000246163.2	-	4	377	c.208C>T	c.(208-210)Ctt>Ttt	p.L70F	MAX_ENST00000555419.1_Intron|MAX_ENST00000284165.6_Intron|MAX_ENST00000555667.1_Intron|MAX_ENST00000358402.4_Intron|MAX_ENST00000557746.1_Intron|MAX_ENST00000556979.1_Intron|MAX_ENST00000555932.1_Intron|MAX_ENST00000557277.1_Intron|RP11-840I19.3_ENST00000556127.1_RNA|MAX_ENST00000556443.1_Intron|MAX_ENST00000358664.4_Intron|MAX_ENST00000341653.2_Intron	NM_145114.1	NP_660089.1	P61244	MAX_HUMAN	MYC associated factor X	0	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		TGACgatgaaggacaggagta	0.313000													46	71					0	0	1	0	0
ADNP	23394	broad.mit.edu	37	20	49511034	49511034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49511034G>A	ENST00000396029.3	-	5	784	c.217C>T	c.(217-219)Cct>Tct	p.P73S	ADNP_ENST00000349014.3_Missense_Mutation_p.P73S|ADNP_ENST00000371602.4_Missense_Mutation_p.P73S|ADNP_ENST00000396032.3_Missense_Mutation_p.P73S	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	73						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						CAGCAGAAAGGTTTTGTCCGA	0.393000													22	70					0	0	1	0	0
PDLIM3	27295	broad.mit.edu	37	4	186429496	186429496	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186429496G>A	ENST00000284770.5	-	5	692	c.619C>T	c.(619-621)Cag>Tag	p.Q207*	PDLIM3_ENST00000284771.6_Intron|PDLIM3_ENST00000284767.5_3'UTR	NM_014476.5	NP_055291.2	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	207						sarcomere	zinc ion binding			breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		ACCTGACCCTGGAGTGTTTCC	0.418000													40	96					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117235007	117235007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117235007G>A	ENST00000003084.6	+	15	2646	c.2514G>A	c.(2512-2514)gaG>gaA	p.E838E	CFTR_ENST00000454343.1_Silent_p.E777E	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	838					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ATGATATGGAGAGCATACCAG	0.333000									Cystic Fibrosis				9	46					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69409764	69409764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69409764C>T	ENST00000303714.4	+	16	1647	c.1325C>T	c.(1324-1326)tCc>tTc	p.S442F		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	442					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CGGCCTTCTTCCCCCCGGAAG	0.423000									Familial Infantile Hemangioma				27	83					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173556856	173556856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173556856G>A	ENST00000367714.3	-	5	893	c.471C>T	c.(469-471)atC>atT	p.I157I	RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Silent_p.I55I	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	157					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										TGCCAAGGGTGATGCTAAAGA	0.323000													19	81					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48741088	48741088	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48741088G>A	ENST00000316623.5	-	46	6003	c.5548C>T	c.(5548-5550)Cgt>Tgt	p.R1850C		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1850	EGF-like 31; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CATTCATTACGATCTGTAAAT	0.348000													17	36					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47041551	47041551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47041551C>T	ENST00000450053.3	+	27	4141	c.3962C>T	c.(3961-3963)cCc>cTc	p.P1321L	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Intron	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1321	Pro-rich.						binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CCCAAGCCACCCACTGAGTCA	0.637000													20	62					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186389428	186389428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186389428C>T	ENST00000232003.4	+	4	488	c.408C>T	c.(406-408)gcC>gcT	p.A136A		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	136	Cystatin 1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CAGCACTGGCCAATACCAAAG	0.433000													40	70					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103908594	103908594	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103908594C>T	ENST00000278070.2	+	12	4677	c.4638C>T	c.(4636-4638)ttC>ttT	p.F1546F	PPRC1_ENST00000370012.1_Silent_p.F513F|PPRC1_ENST00000489648.1_3'UTR|PPRC1_ENST00000413464.2_Silent_p.F1282F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1546	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GGGTGGTCTTCATTGGAAAGA	0.483000													21	40					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24509770	24509770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:24509770G>A	ENST00000264463.4	-	7	1668	c.1161C>T	c.(1159-1161)tcC>tcT	p.S387S		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	387	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ACAGATAGGAGGACCTACTAA	0.393000										HNSCC(23;0.051)			27	53					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29754972	29754972	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29754972G>A	ENST00000389048.3	-	4	1869	c.963C>T	c.(961-963)ctC>ctT	p.L321L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	321	MAM 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGTTGAGAAGGAGAAAGGAGC	0.537000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				13	36					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980903	40980903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40980903G>A	ENST00000373198.3	-	10	1818	c.1583C>T	c.(1582-1584)tCg>tTg	p.S528L	PTPRT_ENST00000373187.1_Missense_Mutation_p.S528L|PTPRT_ENST00000373193.3_Missense_Mutation_p.S528L|PTPRT_ENST00000373201.1_Missense_Mutation_p.S528L|PTPRT_ENST00000373184.1_Missense_Mutation_p.S528L|PTPRT_ENST00000356100.2_Missense_Mutation_p.S528L|PTPRT_ENST00000373190.1_Missense_Mutation_p.S528L	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	528	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGGTCCAGCGAGCCGACAGC	0.532000													34	56					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322829	55322829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55322829G>A	ENST00000314644.2	+	1	1047	c.1047G>A	c.(1045-1047)caG>caA	p.Q349Q		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						AAGTAAAACAGGCCATGAGGA	0.328000										HNSCC(20;0.049)			33	76					0	0	1	0	0
IGLV9-49	28773	broad.mit.edu	37	22	22697996	22697996	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22697996G>A	ENST00000427632.2	+	0	321																											GGCCTGAATCGGTACCTGACC	0.567000											OREG0026357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	18					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540618	40540618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40540618G>A	ENST00000434248.1	-	5	2213	c.2148C>T	c.(2146-2148)taC>taT	p.Y716Y	ZNF780B_ENST00000221355.6_Silent_p.Y568Y	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	716					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGAATTCGGTAATGTTCAG	0.408000													27	74					0	0	1	0	0
DIRC2	84925	broad.mit.edu	37	3	122525735	122525735	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122525735C>T	ENST00000261038.5	+	2	773	c.375C>T	c.(373-375)ttC>ttT	p.F125F		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	125					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		TGACATCCTTCCTTATGGTTT	0.333000													27	60					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41559078	41559078	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41559078C>T	ENST00000396942.1	-	22	2534	c.2451G>A	c.(2449-2451)tcG>tcA	p.S817S	ANK1_ENST00000289734.7_Silent_p.S817S|ANK1_ENST00000347528.4_Silent_p.S817S|ANK1_ENST00000379758.2_Silent_p.S817S|ANK1_ENST00000352337.4_Silent_p.S817S|ANK1_ENST00000265709.8_Silent_p.S850S|ANK1_ENST00000396945.1_Silent_p.S817S			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	817	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTTCATCTTCCGAGACATCCA	0.517000											OREG0018740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	86					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181726163	181726163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181726163C>T	ENST00000526775.1	+	29	4338	c.4173C>T	c.(4171-4173)ttC>ttT	p.F1391F	CACNA1E_ENST00000367570.1_Silent_p.F1410F|CACNA1E_ENST00000367567.4_Silent_p.F1017F|CACNA1E_ENST00000360108.3_Silent_p.F1391F|CACNA1E_ENST00000357570.5_Silent_p.F1361F|CACNA1E_ENST00000358338.5_Silent_p.F1342F|CACNA1E_ENST00000367573.2_Silent_p.F1410F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1410					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TTGTGGTCTTCCCCTTCTTCT	0.488000													46	94					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668411	176668411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176668411C>T	ENST00000367662.3	+	8	4086	c.2922C>T	c.(2920-2922)ttC>ttT	p.F974F		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	974					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CTTCCTTCTTCATGGAGTCCT	0.562000													80	180					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71483628	71483628	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71483628C>T	ENST00000393539.2	-	6	1113	c.300G>A	c.(298-300)aaG>aaA	p.K100K	AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000564528.1_Silent_p.K42K|RP11-510M2.10_ENST00000576258.1_RNA|ZNF23_ENST00000417828.1_Silent_p.K100K|ZNF23_ENST00000497160.1_3'UTR|ZNF23_ENST00000428724.2_Silent_p.K42K|ZNF23_ENST00000357254.4_Silent_p.K100K|ZNF23_ENST00000539742.1_5'UTR	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		TGCTCTTCTCCTTCTTTATAT	0.408000													60	213					0	0	1	0	0
WNT7B	7477	broad.mit.edu	37	22	46318965	46318965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46318965G>A	ENST00000339464.4	-	4	1195	c.821C>T	c.(820-822)tCg>tTg	p.S274L	WNT7B_ENST00000410089.1_Missense_Mutation_p.S258L|WNT7B_ENST00000409496.3_Missense_Mutation_p.S278L	NM_058238.2	NP_478679.1	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family, member 7B	274					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	19		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		GTAGTTGGGCGACTTCTCAAT	0.667000													39	67					0	0	1	0	0
VPS35	55737	broad.mit.edu	37	16	46717501	46717501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:46717501G>A	ENST00000299138.7	-	2	79	c.21C>T	c.(19-21)tcC>tcT	p.S7S		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	7					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CATCCTGAGGGGACTGCTGTG	0.433000													5	28					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30938550	30938550	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30938550G>A	ENST00000597505.1	-	24	3318	c.3319C>T	c.(3319-3321)Cga>Tga	p.R1107*	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Nonsense_Mutation_p.R186*			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GCCTTCATTCGAAGATGAGCT	0.413000													35	57					0	0	1	0	0
XPNPEP3	63929	broad.mit.edu	37	22	41277899	41277899	+	Missense_Mutation	SNP	C	C	T	rs73885709		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41277899C>T	ENST00000357137.4	+	3	391	c.307C>T	c.(307-309)Cct>Tct	p.P103S	XPNPEP3_ENST00000541156.1_Missense_Mutation_p.P103S|XPNPEP3_ENST00000414396.1_Missense_Mutation_p.P103S|XPNPEP3_ENST00000544094.1_Missense_Mutation_p.P80S	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	103					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						GCTCTCCAACCCTACATACTA	0.463000													45	96					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6896531	6896531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6896531G>A	ENST00000312053.4	+	3	254	c.217G>A	c.(217-219)Gat>Aat	p.D73N	EMR1_ENST00000381407.5_Missense_Mutation_p.D73N|EMR1_ENST00000601198.1_3'UTR|EMR1_ENST00000381404.4_Missense_Mutation_p.D73N|EMR1_ENST00000250572.8_Missense_Mutation_p.D73N|EMR1_ENST00000450315.3_Missense_Mutation_p.D73N	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	73	EGF-like 1.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TCACTTCAAGGATCCAGGAGT	0.478000													20	41					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39087996	39087996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39087996C>T	ENST00000591517.1	-	24	1835	c.1807G>A	c.(1807-1809)Gac>Aac	p.D603N	CTB-186G2.1_ENST00000589557.1_RNA|MAP4K1_ENST00000423454.2_3'UTR|MAP4K1_ENST00000589130.1_Missense_Mutation_p.D599N|MAP4K1_ENST00000396857.2_Missense_Mutation_p.D603N|MAP4K1_ENST00000586296.1_Intron	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	603	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCTTTGGTGTCCTGGATCTTG	0.592000													30	311					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44015303	44015303	+	Silent	SNP	C	C	T	rs61732298		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44015303C>T	ENST00000269439.7	+	3	480	c.429C>T	c.(427-429)ttC>ttT	p.F143F	RNF165_ENST00000543885.1_Intron	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	143							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		ATCCCAGCTTCGACTTCGGCC	0.642000													17	57					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1271213	1271213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1271213G>A	ENST00000308624.5	+	14	1283	c.1154G>A	c.(1153-1155)aGg>aAg	p.R385K	SNTG2_ENST00000407292.1_Missense_Mutation_p.R258K	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	385	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GAGGACCAGAGGCCCTATTGC	0.512000													11	20					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123779149	123779149	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:123779149C>T	ENST00000422452.2	-	10	1783	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	TENM1_ENST00000371130.3_Missense_Mutation_p.E574K	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TGTCCTTTCTCGTATTCTCCA	0.498000													122	83					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104642755	104642755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104642755C>T	ENST00000315264.7	+	11	3591	c.3213C>T	c.(3211-3213)ctC>ctT	p.L1071L	KIF26A_ENST00000423312.2_Silent_p.L1210L			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1210					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		ACTCCAGCCTCCCCCGGAAAC	0.721000													9	13					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12826135	12826135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12826135G>A	ENST00000425528.1	-	8	927	c.570C>T	c.(568-570)tcC>tcT	p.S190S	TNPO2_ENST00000441499.1_Silent_p.S190S|TNPO2_ENST00000588216.1_Silent_p.S190S|TNPO2_ENST00000450764.2_Silent_p.S190S|TNPO2_ENST00000356861.5_Silent_p.S190S|TNPO2_ENST00000589956.1_Intron|TNPO2_ENST00000592287.1_Silent_p.S190S			O14787	TNPO2_HUMAN	transportin 2	190					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGATGGCGTGGGACCTGGCGG	0.662000													12	25					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78547308	78547308	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78547308A>C	ENST00000545128.1	+	2	744	c.206A>C	c.(205-207)aAg>aCg	p.K69T	PCSK5_ENST00000376752.4_Missense_Mutation_p.K69T|PCSK5_ENST00000376767.3_Missense_Mutation_p.K69T	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	69					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GGGGCCCTGAAGGACTACTAC	0.408000													22	45					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	167012436	167012436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:167012436C>T	ENST00000061240.2	+	19	3246	c.2599C>T	c.(2599-2601)Cgg>Tgg	p.R867W	TLL1_ENST00000507499.1_Missense_Mutation_p.R890W	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	867	CUB 4.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.R867W(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AATGTTTGTTCGGTTTGTTTC	0.403000													30	69					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9624925	9624925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9624925C>T	ENST00000378429.3	-	4	598	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	PAK7_ENST00000378423.1_Missense_Mutation_p.E18K|PAK7_ENST00000353224.5_Missense_Mutation_p.E18K	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	18	CRIB.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			ACCCTGTGTTCAAAGTTGGAC	0.448000													31	87					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201438338	201438338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:201438338C>T	ENST00000357799.4	+	7	3367	c.3269C>T	c.(3268-3270)cCa>cTa	p.P1090L		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	1090					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						GATCCTTCTCCAGAGAGCCAT	0.368000													55	109					0	0	1	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455657	187455657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187455657G>A	ENST00000307161.5	-	2	440	c.239C>T	c.(238-240)cCg>cTg	p.P80L	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	80					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	CAACGGGTACGGATAAATGGC	0.502000													21	49					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439631	52439631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52439631G>A	ENST00000242819.4	+	2	413	c.117G>A	c.(115-117)aaG>aaA	p.K39K		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	39						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		TTCGCCAGAAGAAACTAATGC	0.488000													24	87					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7012458	7012458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:7012458C>T	ENST00000409757.4	+	11	1721	c.1597C>T	c.(1597-1599)Ctt>Ttt	p.L533F	TBC1D14_ENST00000446947.2_Missense_Mutation_p.L180F|TBC1D14_ENST00000410031.1_Missense_Mutation_p.L305F|TBC1D14_ENST00000448507.1_Missense_Mutation_p.L533F|TBC1D14_ENST00000451522.2_Missense_Mutation_p.L253F	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	533	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						CTTTTCTAACCTTCTGAATAA	0.458000													47	123					0	0	1	0	0
MDFI	4188	broad.mit.edu	37	6	41617481	41617481	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41617481G>A	ENST00000373050.4	+	3	388	c.201G>A	c.(199-201)cgG>cgA	p.R67R				Q99750	MDFI_HUMAN	MyoD family inhibitor	128					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			AGGCCCACCGGAAGTTGCAGA	0.647000													68	141					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74019403	74019403	+	Silent	SNP	G	G	A	rs148972745		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74019403G>A	ENST00000301607.3	-	4	703	c.450C>T	c.(448-450)gtC>gtT	p.V150V	EVPL_ENST00000586740.1_Silent_p.V150V	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	150	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GTGCCCAGTCGACCCTGGGTC	0.607000													38	90					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520248	131520248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131520248C>T	ENST00000423981.1	+	2	713	c.603C>T	c.(601-603)ttC>ttT	p.F201F	AMER3_ENST00000321420.4_Silent_p.F201F	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GCAAAGCCTTCCTCCCCCCGG	0.687000													20	47					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34164424	34164424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34164424C>T	ENST00000373381.4	-	24	4030	c.3854G>A	c.(3853-3855)cGg>cAg	p.R1285Q	CSMD2_ENST00000373380.1_Missense_Mutation_p.R158Q|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1245	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTCACTACCCCGCAGGCTGTA	0.607000													10	105					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68156997	68156997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68156997C>T	ENST00000349223.5	+	2	1435	c.1211C>T	c.(1210-1212)cCa>cTa	p.P404L	NFATC3_ENST00000575270.1_Missense_Mutation_p.P404L|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.P404L|NFATC3_ENST00000329524.4_Missense_Mutation_p.P404L	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	404					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TGGAGCAAACCAAAGCCTGGC	0.413000													28	124					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19575479	19575479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:19575479C>T	ENST00000328405.2	+	16	3478	c.3212C>T	c.(3211-3213)tCt>tTt	p.S1071F		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	1071						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						TTACCAGGATCTTGGAACCAG	0.473000													19	50					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359505	66359505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66359505G>A	ENST00000333861.3	-	1	1049	c.982C>T	c.(982-984)Cct>Tct	p.P328S		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	328										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GGGAGTGGAGGAAGGCCCAAC	0.617000													12	66					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88402646	88402646	+	Missense_Mutation	SNP	C	C	T	rs146646005		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:88402646C>T	ENST00000419482.2	+	7	1043	c.958C>T	c.(958-960)Cgt>Tgt	p.R320C	SMYD1_ENST00000444564.2_Missense_Mutation_p.R307C|SMYD1_ENST00000438570.1_Intron	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						AGACAAGGCTCGTTCCGAGGG	0.463000													21	35					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92085731	92085731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92085731G>A	ENST00000298047.6	+	1	470	c.453G>A	c.(451-453)atG>atA	p.M151I	FAT3_ENST00000525166.1_Start_Codon_SNP_p.M1I|FAT3_ENST00000409404.2_Missense_Mutation_p.M151I|FAT3_ENST00000541502.1_Missense_Mutation_p.M151I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	151	Cadherin 1.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTTAGATATGAATGATCTGA	0.403000										TCGA Ovarian(4;0.039)			25	46					0	0	1	0	0
HMGCR	3156	broad.mit.edu	37	5	74655281	74655281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:74655281C>T	ENST00000287936.4	+	18	2513	c.2357C>T	c.(2356-2358)cCc>cTc	p.P786L	HMGCR_ENST00000511206.1_Missense_Mutation_p.P786L|HMGCR_ENST00000343975.5_Missense_Mutation_p.P733L	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	786	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GCAAGTGGTCCCACAAATGAA	0.403000													11	74					0	0	1	0	0
ZDHHC1	29800	broad.mit.edu	37	16	67440214	67440214	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67440214G>A	ENST00000348579.2	-	3	482	c.141C>T	c.(139-141)ccC>ccT	p.P47P		NM_013304.2	NP_037436.1	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	47						integral to membrane	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|urinary_tract(1)	10		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		GCGGGTGAGGGGGCCAGCTCC	0.667000													5	12					0	0	1	0	0
CDK3	1018	broad.mit.edu	37	17	73998208	73998208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73998208C>T	ENST00000425876.2	+	3	388	c.300C>T	c.(298-300)ccC>ccT	p.P100P	TEN1-CDK3_ENST00000567351.1_RNA|CDK3_ENST00000448471.1_Silent_p.P100P			Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	100	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						CAGAGCTCCCCCTGCACCTCA	0.597000													20	56					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228487768	228487768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228487768G>A	ENST00000570156.2	+	51	13734	c.13660G>A	c.(13660-13662)Ggc>Agc	p.G4554S	RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000366707.4_Missense_Mutation_p.G1244S|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000602685.1_3'UTR|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000359599.6_3'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3597	Fibronectin type-III 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCAGATTCGTGGCCTGGTCAT	0.587000													28	62					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013558	75013558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75013558G>A	ENST00000379727.3	-	5	1346	c.1148C>T	c.(1147-1149)cCc>cTc	p.P383L	CYP1A1_ENST00000395049.4_Missense_Mutation_p.P383L|CYP1A1_ENST00000567032.1_Missense_Mutation_p.P383L|CYP1A1_ENST00000564596.1_Missense_Mutation_p.P122L|CYP1A1_ENST00000395048.2_Missense_Mutation_p.P383L			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	383					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	GATGGTGAAGGGGACGAAGGA	0.577000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				44	147					0	0	1	0	0
MVP	9961	broad.mit.edu	37	16	29856019	29856019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29856019C>T	ENST00000357402.5	+	11	1978	c.1840C>T	c.(1840-1842)Ccc>Tcc	p.P614S	MVP_ENST00000395353.1_Missense_Mutation_p.P614S	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	614					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						AGCGAAGGGCCCCGATGGCAT	0.622000													53	122					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13418659	13418659	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13418659G>A	ENST00000360228.5	-	15	1922	c.1923C>T	c.(1921-1923)ttC>ttT	p.F641F	CACNA1A_ENST00000573710.2_Silent_p.F642F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	642					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCCCTTCATCGAAATTAAACC	0.547000													19	91					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644608	169644608	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169644608A>T	ENST00000428432.2	+	6	947	c.558A>T	c.(556-558)aaA>aaT	p.K186N	SAMD7_ENST00000335556.3_Missense_Mutation_p.K186N	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	186										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GACTCAGGAAAAATACAGGGA	0.483000													29	74					0	0	1	0	0
KCNE1L	23630	broad.mit.edu	37	X	108867989	108867989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:108867989G>A	ENST00000372101.2	-	1	404	c.261C>T	c.(259-261)ctC>ctT	p.L87L	RP1-136J15.3_ENST00000439581.1_RNA	NM_012282.2	NP_036414.1	Q9UJ90	KCE1L_HUMAN	KCNE1-like	87					regulation of heart contraction	voltage-gated potassium channel complex				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6						TGGCCTCGACGAGCTTACGGG	0.687000													4	20					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214815813	214815813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:214815813C>T	ENST00000366955.3	+	12	4300	c.4132C>T	c.(4132-4134)Cct>Tct	p.P1378S		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1475					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGAACAGCACCCTGTGTCTTT	0.408000													6	68					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129281993	129281993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129281993G>A	ENST00000393239.1	-	26	4790	c.4612C>T	c.(4612-4614)Cgc>Tgc	p.R1538C	PLXND1_ENST00000324093.4_Missense_Mutation_p.R1538C			Q9Y4D7	PLXD1_HUMAN	plexin D1	1538					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						AGTGTGTAGCGGGCCTTGCCT	0.642000													6	34					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14819293	14819293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14819293C>T	ENST00000380881.4	-	15	3303	c.2488G>A	c.(2488-2490)Gga>Aga	p.G830R	FREM1_ENST00000380880.3_Missense_Mutation_p.G829R|FREM1_ENST00000422223.2_Missense_Mutation_p.G829R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	829					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGAGGAAATCCATTCAGCTCC	0.433000													6	43					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143098605	143098605	+	Missense_Mutation	SNP	G	G	A	rs74721927	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143098605G>A	ENST00000275815.3	-	3	330	c.244C>T	c.(244-246)Cgc>Tgc	p.R82C		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	82						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CAATTGGAGCGAAGCCAGTGG	0.602000													20	249					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95090041	95090041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95090041G>A	ENST00000553947.1	+	8	2125	c.1237G>A	c.(1237-1239)Gag>Aag	p.E413K	SERPINA3_ENST00000467132.1_Missense_Mutation_p.E388K|SERPINA3_ENST00000393080.4_Missense_Mutation_p.E388K|SERPINA3_ENST00000482740.1_Missense_Mutation_p.E170K|SERPINA3_ENST00000393078.3_Missense_Mutation_p.E388K			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	388					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TGCATTAGTGGAGACAAGGAC	0.493000													37	100					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167796359	167796359	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:167796359C>T	ENST00000366827.2	-	2	214	c.3G>A	c.(1-3)atG>atA	p.M1I	TCP10_ENST00000397829.4_Start_Codon_SNP_p.M1I|TCP10_ENST00000476779.2_Start_Codon_SNP_p.M1I			Q12799	TCP10_HUMAN	t-complex 10	28						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		GTGTCTTCTCCATGGCAGCCC	0.662000													5	10					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107517425	107517425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:107517425C>T	ENST00000416476.2	+	15	1620	c.1400C>T	c.(1399-1401)tCc>tTc	p.S467F	BBX_ENST00000325805.8_Silent_p.I803I|BBX_ENST00000473542.1_3'UTR|BBX_ENST00000402543.1_Silent_p.I753I|BBX_ENST00000406780.1_Silent_p.I773I|BBX_ENST00000415149.2_Silent_p.I773I			Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	0	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TTAAAAATATCCCATCCATTT	0.403000													26	79					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735280	13735280	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13735280C>T	ENST00000265104.4	-	68	11825	c.11721G>A	c.(11719-11721)agG>agA	p.R3907R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3907					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGACTCGGTTCCTCTGGATGT	0.438000									Kartagener syndrome				8	86					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123599966	123599966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123599966C>T	ENST00000340011.5	+	5	1830	c.1473C>T	c.(1471-1473)gcC>gcT	p.A491A	SPAM1_ENST00000460182.1_Silent_p.A491A|SPAM1_ENST00000439500.1_Silent_p.A491A|SPAM1_ENST00000223028.7_Silent_p.A491A|SPAM1_ENST00000402183.2_Silent_p.A491A	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	491					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	CACTATCTGCCACAATGTTCA	0.373000													33	74					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238053390	238053390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:238053390C>T	ENST00000366570.4	-	2	420	c.262G>A	c.(262-264)Gag>Aag	p.E88K	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	88					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TAGGTTGCCTCCAACACCACG	0.582000													38	88					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50391759	50391759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50391759C>T	ENST00000221543.5	+	17	2124	c.1825C>T	c.(1825-1827)Ccg>Tcg	p.P609S	TBC1D17_ENST00000535102.2_Missense_Mutation_p.P576S	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	609	Pro-rich.					intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CACCGCCTCCCCGCTGCCTCT	0.746000													3	12					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247694899	247694899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247694899C>T	ENST00000366487.3	-	2	1276	c.915G>A	c.(913-915)atG>atA	p.M305I	GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000527541.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TCTCTAATACCATGTGCCGGA	0.507000													18	48					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185012502	185012502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:185012502C>T	ENST00000296741.2	-	8	1292	c.1151G>A	c.(1150-1152)aGg>aAg	p.R384K		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	384					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GTCCACCGACCTGATAGGAGC	0.542000													8	98					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145109485	145109485	+	Missense_Mutation	SNP	C	C	T	rs149290437	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145109485C>T	ENST00000426825.1	-	19	2746	c.2665G>A	c.(2665-2667)Ggg>Agg	p.G889R	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	889							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	AAGACGCCCCCCTGGACAAGT	0.647000													6	17					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94882608	94882608	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94882608G>A	ENST00000331706.4	+	0	792				MCTP2_ENST00000543482.1_Missense_Mutation_p.D243N|MCTP2_ENST00000451018.3_Missense_Mutation_p.D243N|MCTP2_ENST00000357742.4_Missense_Mutation_p.D243N			Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CCCAGTATGGGATGAGATAGT	0.358000													43	145					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120332	38120332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38120332C>T	ENST00000406386.3	+	7	2024	c.1769C>T	c.(1768-1770)cCc>cTc	p.P590L	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	590					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GCCTCCTCTCCCAATAGAGCT	0.572000													45	223					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294023	124294023	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124294023G>A	ENST00000356130.3	-	1	766	c.745C>T	c.(745-747)Ctg>Ttg	p.L249L		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CCAAAAAACAGAGCAACAGCA	0.458000													7	64					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32526728	32526728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32526728G>A	ENST00000286827.3	-	18	3479	c.3008C>T	c.(3007-3009)gCc>gTc	p.A1003V	TIAM1_ENST00000541036.1_Missense_Mutation_p.A943V	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1003					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GCAAAATGCGGCCACCTGTTC	0.582000													27	70					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234878915	234878915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234878915C>T	ENST00000324695.4	+	17	2240	c.2200C>T	c.(2200-2202)Ccc>Tcc	p.P734S	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	734						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTTCACCTCCCCCTTCGTGGT	0.537000													91	250					0	0	1	0	0
FSHB	2488	broad.mit.edu	37	11	30255248	30255248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30255248C>T	ENST00000417547.1	+	3	330	c.291C>T	c.(289-291)gcC>gcT	p.A97A	FSHB_ENST00000533718.1_Silent_p.A97A|FSHB_ENST00000254122.3_Silent_p.A97A	NM_001018080.1	NP_001018090.1	P01225	FSHB_HUMAN	follicle stimulating hormone, beta polypeptide	97					cellular nitrogen compound metabolic process|female gamete generation|female pregnancy|ovarian follicle development|peptide hormone processing|progesterone biosynthetic process|spermatogenesis|transforming growth factor beta receptor signaling pathway	cytoplasm|extracellular region|soluble fraction	follicle-stimulating hormone activity|protein heterodimerization activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(3)|skin(1)	12					Follitropin beta(DB00066)|Thyrotropin Alfa(DB00024)|Urofollitropin(DB00094)	ACCCAGTGGCCACCCAGTGTC	0.498000													17	36					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97167502	97167502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97167502C>T	ENST00000389672.5	+	7	1860	c.1822C>T	c.(1822-1824)Cac>Tac	p.H608Y	EPHA6_ENST00000514100.1_5'UTR|EPHA6_ENST00000502694.1_5'UTR|EPHA6_ENST00000442602.2_5'UTR	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	513						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						ATATGTATTTCACATCCGAGT	0.443000													13	100					0	0	1	0	0
FXYD5	53827	broad.mit.edu	37	19	35657175	35657175	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35657175G>A	ENST00000342879.3	+	7	1212	c.434G>A	c.(433-435)cGg>cAg	p.R145Q	FXYD5_ENST00000588699.1_Missense_Mutation_p.R145Q|FXYD5_ENST00000543307.1_Missense_Mutation_p.R145Q|FXYD5_ENST00000541435.2_Missense_Mutation_p.R145Q|FXYD5_ENST00000423817.3_Missense_Mutation_p.R145Q|FXYD5_ENST00000392219.2_Missense_Mutation_p.R145Q|FXYD5_ENST00000392217.3_Missense_Mutation_p.R74Q|FXYD5_ENST00000591716.2_3'UTR|FXYD5_ENST00000590686.1_Missense_Mutation_p.R145Q			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	145					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CTCCGGAAACGGGGGCTGTTG	0.547000													72	270					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537901	55537901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55537901G>A	ENST00000220676.1	+	4	1607	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	487					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCATATAGTGAAGAAAGGGA	0.363000													28	67					0	0	1	0	0
RNF175	285533	broad.mit.edu	37	4	154633721	154633721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:154633721C>T	ENST00000347063.4	-	8	1144	c.772G>A	c.(772-774)Gaa>Aaa	p.E258K		NM_173662.2	NP_775933.1	Q8N4F7	RN175_HUMAN	ring finger protein 175	258						integral to membrane	zinc ion binding			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	13	all_hematologic(180;0.093)	Renal(120;0.118)				ATGCAGAATTCATGAAAGCTG	0.438000													3	20					0	0	1	0	0
ABCG1	9619	broad.mit.edu	37	21	43716295	43716295	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43716295C>T	ENST00000398437.1	+	16	2416	c.2268C>T	c.(2266-2268)atC>atT	p.I756I	ABCG1_ENST00000340588.4_Silent_p.I718I|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000398449.3_Silent_p.I598I|ABCG1_ENST00000343687.3_Silent_p.I609I|ABCG1_ENST00000398457.2_Silent_p.I600I|ABCG1_ENST00000361802.2_Silent_p.I610I|ABCG1_ENST00000347800.2_Silent_p.I595I			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	610					amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	AAGGGGTCATCCTCTCCATCT	0.592000													24	55					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37271906	37271906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:37271906C>T	ENST00000373091.3	-	14	2129	c.2113G>A	c.(2113-2115)Gag>Aag	p.E705K	GRIK3_ENST00000373093.4_Missense_Mutation_p.E705K	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	705					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CACATCTTCTCGAAGGTGGAG	0.602000													7	28					0	0	1	0	0
REPIN1	29803	broad.mit.edu	37	7	150069245	150069245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150069245C>T	ENST00000397281.2	+	4	1404	c.915C>T	c.(913-915)ccC>ccT	p.P305P	REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000489432.2_Silent_p.P362P|REPIN1_ENST00000425389.2_Silent_p.P305P|REPIN1_ENST00000540729.1_Silent_p.P305P|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000444957.1_Silent_p.P305P	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	305					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GGCACAAACCCAACCTGCTGT	0.672000													11	16					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57148260	57148260	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:57148260G>A	ENST00000376149.3	-	9	1176	c.367C>T	c.(367-369)Ctt>Ttt	p.L123F	TRIM37_ENST00000393065.2_Missense_Mutation_p.L211F|TRIM37_ENST00000262294.7_Missense_Mutation_p.L245F|TRIM37_ENST00000393066.3_Missense_Mutation_p.L245F			O94972	TRI37_HUMAN	tripartite motif containing 37	245						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AACATCATAAGGATCTCTGAG	0.388000									Mulibrey Nanism				25	70					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21136605	21136605	+	Missense_Mutation	SNP	C	C	T	rs139455188	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21136605C>T	ENST00000261383.3	-	9	1294	c.1295G>A	c.(1294-1296)cGa>cAa	p.R432Q	CTC-508F8.1_ENST00000575612.1_RNA|DNAH3_ENST00000415178.1_Missense_Mutation_p.R432Q	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	432	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R432Q(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CTCAATGTTTCGACTTGAGTC	0.473000													21	84					0	0	1	0	0
DEFA4	1669	broad.mit.edu	37	8	6793654	6793654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:6793654C>T	ENST00000297435.2	-	3	306	c.182G>A	c.(181-183)aGg>aAg	p.R61K		NM_001925.1	NP_001916.1	P12838	DEF4_HUMAN	defensin, alpha 4, corticostatin	61					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	10				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		GACCATGCCCCTTGTTGAGCC	0.517000													9	47					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55268032	55268032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55268032C>T	ENST00000275493.2	+	24	3049	c.2872C>T	c.(2872-2874)Cgc>Tgc	p.R958C	EGFR_ENST00000454757.2_Missense_Mutation_p.R905C|EGFR_ENST00000455089.1_Missense_Mutation_p.R913C|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	958	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCAGATAGTCGCCCAAAGTT	0.458000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			29	101					0	0	1	0	0
SSUH2	51066	broad.mit.edu	37	3	8675490	8675490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:8675490G>A	ENST00000317371.4	-	11	1360	c.135C>T	c.(133-135)gtC>gtT	p.V45V	SSUH2_ENST00000544814.1_Intron|SSUH2_ENST00000341795.3_Silent_p.V45V|SSUH2_ENST00000415132.1_Silent_p.V45V					ssu-2 homolog (C. elegans)																		CTCTGCAGGGGACCGAACAGA	0.652000													9	22					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29365268	29365268	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29365268G>A	ENST00000383555.2	+	1	853	c.792G>A	c.(790-792)gaG>gaA	p.E264E	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E264D(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						CTGCGTTAGAGAGCTTCATGG	0.458000													70	163					0	0	1	0	0
GHITM	27069	broad.mit.edu	37	10	85904638	85904638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85904638C>T	ENST00000372134.3	+	5	542	c.349C>T	c.(349-351)Cct>Tct	p.P117S		NM_014394.2	NP_055209.2	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	117					apoptosis	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(2)	10						CAGAATTTGGCCTCAGTATGT	0.398000													10	85					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519973	113519973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113519973C>T	ENST00000284601.3	-	4	1242	c.1174G>A	c.(1174-1176)Gaa>Aaa	p.E392K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	392					glycogen metabolic process	integral to membrane		p.E392K(1)		NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GAATATTTTTCATTGCAGTAA	0.398000													66	147					0	0	1	0	0
METTL22	79091	broad.mit.edu	37	16	8736037	8736037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:8736037C>T	ENST00000381920.3	+	8	1138	c.880C>T	c.(880-882)Cac>Tac	p.H294Y	METTL22_ENST00000561758.1_Missense_Mutation_p.H238Y|METTL22_ENST00000568967.1_3'UTR	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	294							methyltransferase activity			large_intestine(5)|lung(4)	9						CTTGTACGATCACACCACCAT	0.468000													10	87					0	0	1	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3386026	3386026	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3386026C>T	ENST00000378378.4	+	6	1296	c.891C>T	c.(889-891)ttC>ttT	p.F297F	ARHGEF16_ENST00000378373.1_Silent_p.F9F|ARHGEF16_ENST00000378371.2_Silent_p.F9F	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	297	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		CGTCGGAGTTCTCCTACCAGC	0.627000													18	63					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123842627	123842627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123842627C>T	ENST00000369005.1	+	4	952	c.612C>T	c.(610-612)ccC>ccT	p.P204P	TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Silent_p.P204P|TACC2_ENST00000334433.3_Silent_p.P204P|TACC2_ENST00000515273.1_Silent_p.P204P|TACC2_ENST00000453444.2_Silent_p.P204P	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	204						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CGCCAGTACCCCTCAGAGAGC	0.582000													4	46					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71036968	71036968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:71036968G>A	ENST00000452400.2	-	20	4230	c.4049C>T	c.(4048-4050)cCc>cTc	p.P1350L	NCOA2_ENST00000267974.4_Missense_Mutation_p.P438L	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1350					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TATGTCGGAGGGGGCCTGATA	0.562000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								8	52					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77171000	77171000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:77171000C>T	ENST00000253506.5	+	2	1094	c.725C>T	c.(724-726)cCc>cTc	p.P242L	NFATC1_ENST00000592223.1_Missense_Mutation_p.P229L|NFATC1_ENST00000591814.1_Missense_Mutation_p.P242L|NFATC1_ENST00000586434.1_Missense_Mutation_p.P229L|NFATC1_ENST00000329101.4_Missense_Mutation_p.P229L|NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000542384.1_Missense_Mutation_p.P242L|NFATC1_ENST00000427363.2_Missense_Mutation_p.P242L|NFATC1_ENST00000318065.5_Missense_Mutation_p.P229L|NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000587635.1_Missense_Mutation_p.P242L	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	242	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		TCCACCTCGCCCCGCGCCAGC	0.711000													6	39					0	0	1	0	0
LRRC37A5P	652972	broad.mit.edu	37	9	114371455	114371455	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114371455C>T	ENST00000374304.1	-	0	344																											AGTCCGTCTTCAAGGTCCGGA	0.498000													16	126					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125131980	125131980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125131980C>T	ENST00000522917.1	+	41	5729	c.5523C>T	c.(5521-5523)ttC>ttT	p.F1841F	FER1L6_ENST00000399018.1_Silent_p.F1841F|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1841						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			tcgtccttttcatcTACACCT	0.463000													34	137					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14156999	14156999	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:14156999G>A	ENST00000310358.7	+	0	1245							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		ATCATCGGAGGATCCCACTCC	0.507000													20	66					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21564648	21564648	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21564648G>A	ENST00000415912.2	-	11	1445	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F	ECE1_ENST00000436918.2_Silent_p.F456F|ECE1_ENST00000264205.6_Silent_p.F453F|ECE1_ENST00000374893.6_Silent_p.F456F|ECE1_ENST00000528294.1_5'UTR|ECE1_ENST00000357071.4_Silent_p.F444F	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	456					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TGTCCTCGGCGAAGGTTGCTT	0.542000													23	58					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25406065	25406065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25406065G>A	ENST00000255324.5	+	18	2483	c.2431G>A	c.(2431-2433)Gaa>Aaa	p.E811K	RNF17_ENST00000381921.1_Missense_Mutation_p.E811K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	811					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AGAAGCTAAAGAAAAATTTGA	0.289000													23	39					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41797425	41797425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41797425C>T	ENST00000263800.6	-	15	2002	c.1906G>A	c.(1906-1908)Gaa>Aaa	p.E636K	LTK_ENST00000355166.5_Missense_Mutation_p.E575K|LTK_ENST00000453182.2_Missense_Mutation_p.E506K|LTK_ENST00000561619.1_Missense_Mutation_p.E334K	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	636	Protein kinase.				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		AAGTGATTTTCCTCCAGGTAG	0.602000										TSP Lung(18;0.14)			33	20					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70951717	70951717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70951717G>A	ENST00000357250.6	-	30	2106	c.1948C>T	c.(1948-1950)Ctc>Ttc	p.L650F	COL9A1_ENST00000370499.4_Missense_Mutation_p.L407F|COL9A1_ENST00000489611.1_Intron|RP1-149L1.1_ENST00000522264.1_RNA|COL9A1_ENST00000320755.7_Missense_Mutation_p.L407F	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	650	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AAGCCAGGGAGGCCAGGGCTA	0.532000													6	9					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25258636	25258636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:25258636G>A	ENST00000328086.7	-	5	1684	c.881C>T	c.(880-882)tCc>tTc	p.S294F		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	294	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		CTTGTTAGAGGAATGCAGACC	0.428000													9	94					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33998741	33998741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33998741G>A	ENST00000373381.4	-	64	10256	c.10080C>T	c.(10078-10080)tcC>tcT	p.S3360S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3216						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTCCTGGCAGGAGTAGATGA	0.652000													11	27					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31577457	31577457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31577457G>A	ENST00000356173.3	-	9	674	c.582C>T	c.(580-582)atC>atT	p.I194I	SUN5_ENST00000375523.3_Silent_p.I169I	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	194					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						CTGGCTTTTCGATGTAATCTC	0.483000													15	55					0	0	1	0	0
ANKRD54	129138	broad.mit.edu	37	22	38234576	38234576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38234576G>A	ENST00000215941.4	-	3	598	c.406C>T	c.(406-408)Ccc>Tcc	p.P136S	ANKRD54_ENST00000406423.1_Missense_Mutation_p.P16S|ANKRD54_ENST00000411961.2_Missense_Mutation_p.P120S	NM_138797.2	NP_620152.1	Q6NXT1	ANR54_HUMAN	ankyrin repeat domain 54	136										lung(1)	1	Melanoma(58;0.045)					GCTGCACAGGGATCCGCGCCA	0.592000													3	19					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39066565	39066565	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39066565C>T	ENST00000355481.4	+	96	14252	c.14121C>T	c.(14119-14121)ttC>ttT	p.F4707F	RYR1_ENST00000359596.3_Silent_p.F4712F|RYR1_ENST00000360985.3_Silent_p.F4707F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4712					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCAGGTCTTTCCCTAGCAACT	0.557000													28	70					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47538911	47538911	+	Missense_Mutation	SNP	G	G	A	rs149876632		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47538911G>A	ENST00000273859.3	+	9	1621	c.1352G>A	c.(1351-1353)cGa>cAa	p.R451Q	ATP10D_ENST00000504445.1_Missense_Mutation_p.R436Q	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	451					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						ATGGTTTTTCGAAGATGTAGT	0.443000													24	24					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46657680	46657680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46657680C>T	ENST00000253255.5	-	1	1539	c.1540G>A	c.(1540-1542)Gga>Aga	p.G514R		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	514	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CCATTCCTTCCTGTTACAGTT	0.388000													89	217					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105831820	105831820	+	Nonsense_Mutation	SNP	G	G	A	rs121912774		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105831820G>A	ENST00000353479.5	-	8	723	c.433C>T	c.(433-435)Cga>Tga	p.R145*	COL17A1_ENST00000369733.3_Nonsense_Mutation_p.R145*|COL17A1_ENST00000393211.3_Nonsense_Mutation_p.R145*	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	145	Necessary for interaction with DST and for the recruitment of DST to hemidesmosome.|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CTCTGCAGTCGAACTCGAATT	0.488000													23	36					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1785174	1785174	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1785174C>T	ENST00000539485.1	-	27	3779	c.3546G>A	c.(3544-3546)acG>acA	p.T1182T	ATP8B3_ENST00000525591.1_Silent_p.T1135T|ATP8B3_ENST00000310127.6_Silent_p.T1172T			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	1172					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGGGAAGGTCGTGGGGGATA	0.617000													4	7					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94068088	94068088	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:94068088G>A	ENST00000369303.4	-	4	1058	c.874C>T	c.(874-876)Cag>Tag	p.Q292*		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	292	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CGAGAGCACTGAAGATCTTGA	0.433000													9	41					0	0	1	0	0
DIO2	1734	broad.mit.edu	37	14	80669428	80669428	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:80669428G>A	ENST00000557125.1	-	2	49	c.48_splice	c.e2-1	p.P17_splice	DIO2_ENST00000438257.4_Silent_p.A142A|DIO2_ENST00000422005.3_3'UTR|DIO2_ENST00000557010.1_Silent_p.A142A|DIO2_ENST00000555750.1_Silent_p.A178A			Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	0					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding	p.A178A(1)|p.A142A(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		GTTTGCGGAAGGCTGGCAGCT	0.572000											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	21					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50282174	50282174	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:50282174C>T	ENST00000404971.1	-	21	5186	c.3847G>A	c.(3847-3849)Gat>Aat	p.D1283N	NRXN1_ENST00000342183.5_Intron|NRXN1_ENST00000402717.3_Missense_Mutation_p.D1235N|NRXN1_ENST00000401669.2_Missense_Mutation_p.D1243N|NRXN1_ENST00000401710.1_Intron|NRXN1_ENST00000406316.2_Intron|NRXN1_ENST00000405472.3_Missense_Mutation_p.D1235N|NRXN1_ENST00000406859.3_Intron	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1239	Laminin G-like 6.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CGCTCGTTATCATTGTTTCCT	0.358000													10	22					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28997133	28997133	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:28997133G>A	ENST00000322982.3	-	0	801							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GTTGCCCAAGGGAGCGAAGAC	0.652000													11	33					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	110222987	110222987	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110222987G>A	ENST00000399132.1	-	2	719	c.189C>T	c.(187-189)atC>atT	p.I63I	COL25A1_ENST00000399126.1_Silent_p.I63I|COL25A1_ENST00000399127.1_Silent_p.I63I	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	63						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CGAGAGCGGCGATCCTCGCCT	0.607000													11	149					0	0	1	0	0
ABCB7	22	broad.mit.edu	37	X	74284974	74284974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:74284974G>A	ENST00000253577.3	-	13	1789	c.1765C>T	c.(1765-1767)Cat>Tat	p.H589Y	ABCB7_ENST00000339447.4_Missense_Mutation_p.H548Y|ABCB7_ENST00000373394.3_Missense_Mutation_p.H588Y	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	588	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity	p.H589Y(1)		breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						ATTGCATCATGAAGTCCAGCT	0.433000													18	12					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32415222	32415222	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:32415222G>A	ENST00000265069.8	-	5	738	c.636C>T	c.(634-636)gcC>gcT	p.A212A		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	212	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		CTGGTTTTATGGCTGTCACTT	0.498000													21	55					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61829395	61829395	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61829395C>T	ENST00000280772.1	-	37	11435	c.11244G>A	c.(11242-11244)gtG>gtA	p.V3748V	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3748					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AACTGGTCATCACCGCTTCTA	0.418000													60	156					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47692738	47692738	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47692738G>A	ENST00000397708.1	-	9	2456	c.2202C>T	c.(2200-2202)atC>atT	p.I734I	MCM3AP_ENST00000291688.1_Silent_p.I734I			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	734					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					GCTGCTGCGTGATATCCTGGC	0.547000													27	56					0	0	1	0	0
SLC7A3	84889	broad.mit.edu	37	X	70145692	70145692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70145692G>A	ENST00000374299.3	-	12	1975	c.1831C>T	c.(1831-1833)Ccc>Tcc	p.P611S	SLC7A3_ENST00000298085.4_Missense_Mutation_p.P611S			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	611					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	AGAGTGCCGGGATCAAGGTCT	0.498000													29	21					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133196570	133196570	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133196570C>T	ENST00000388996.4	-	3	942	c.522G>A	c.(520-522)agG>agA	p.R174R	KCNQ3_ENST00000519445.1_Silent_p.R174R|KCNQ3_ENST00000521134.1_Silent_p.R54R	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	174					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CAGCCCAGATCCTCAAAGCAA	0.532000													38	94					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153149857	153149857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153149857C>T	ENST00000285900.5	+	13	2495	c.2152C>T	c.(2152-2154)Ctg>Ttg	p.L718L	GRIA1_ENST00000518142.1_Silent_p.L638L|GRIA1_ENST00000518783.1_Silent_p.L728L|GRIA1_ENST00000521843.2_Silent_p.L649L|GRIA1_ENST00000448073.4_Silent_p.L728L|GRIA1_ENST00000340592.5_Silent_p.L718L	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	718					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGCCTACCTCCTGGAGTCCAC	0.498000													16	46					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11289038	11289038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11289038G>A	ENST00000432929.2	-	6	1887	c.1527C>T	c.(1525-1527)ttC>ttT	p.F509F	KANK2_ENST00000355150.5_Silent_p.F501F|KANK2_ENST00000586659.1_Silent_p.F501F|KANK2_ENST00000589359.1_Silent_p.F509F|KANK2_ENST00000589894.1_Silent_p.F501F	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	501										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TGACCCCCACGAACTGGAGGC	0.647000													13	16					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124050683	124050683	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124050683C>T	ENST00000368994.2	+	7	818	c.567C>T	c.(565-567)atC>atT	p.I189I	BTBD16_ENST00000260723.4_Silent_p.I188I			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	188	BTB.									breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CCGCCCACATCCTCCAGTTCA	0.577000													32	86					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181764162	181764162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181764162C>T	ENST00000526775.1	+	44	6169	c.6004C>T	c.(6004-6006)Cgc>Tgc	p.R2002C	CACNA1E_ENST00000367570.1_Missense_Mutation_p.R2021C|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R1628C|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R2045C|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R2015C|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1953C|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R2064C	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2064					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GTCAGCCCACCGCCTGAACTC	0.547000													12	35					0	0	1	0	0
TEPP	374739	broad.mit.edu	37	16	58019364	58019364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58019364C>T	ENST00000290871.5	+	6	784	c.747C>T	c.(745-747)ccC>ccT	p.P249P	TEPP_ENST00000441824.2_Intron|TEPP_ENST00000569996.1_Intron	NM_199046.2	NP_950247.2	Q6URK8	TEPP_HUMAN	testis, prostate and placenta expressed	229						extracellular region				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	8						CACCGCGCCCCTATCCCTGCT	0.672000													19	35					0	0	1	0	0
TMEM44	93109	broad.mit.edu	37	3	194344019	194344019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:194344019G>A	ENST00000392432.2	-	5	751	c.546C>T	c.(544-546)ggC>ggT	p.G182G	TMEM44_ENST00000473092.1_Silent_p.G182G|TMEM44_ENST00000381975.3_Silent_p.G182G|TMEM44_ENST00000347147.4_Silent_p.G182G|TMEM44_ENST00000330115.3_Silent_p.G79G|TMEM44_ENST00000273580.7_Silent_p.G182G	NM_001166305.1	NP_001159777.1	Q2T9K0	TMM44_HUMAN	transmembrane protein 44	182						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|urinary_tract(1)	8	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		CCAGCAGGTAGCCGAGGATCT	0.577000													7	9					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5322321	5322321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5322321G>A	ENST00000380224.1	-	1	905	c.856C>T	c.(856-858)Cct>Tct	p.P286S	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAAATGATAGGATTCACGAAT	0.428000													13	69					0	0	1	0	0
SHOX2	6474	broad.mit.edu	37	3	157817725	157817725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:157817725C>T	ENST00000490689.2	-	4	1772	c.239G>A	c.(238-240)gGg>gAg	p.G80E	SHOX2_ENST00000389589.4_Missense_Mutation_p.G233E|SHOX2_ENST00000441443.2_Missense_Mutation_p.G80E|SHOX2_ENST00000425436.3_Missense_Mutation_p.G209E|SHOX2_ENST00000483851.2_Missense_Mutation_p.G209E			O60902	SHOX2_HUMAN	short stature homeobox 2	209	Poly-Gly.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(10)|skin(3)|upper_aerodigestive_tract(1)	20			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GCTGGCGGCCCCTATGAGAAC	0.438000													10	43					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76744366	76744366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76744366G>A	ENST00000369963.3	-	2	395	c.206C>T	c.(205-207)tCc>tTc	p.S69F	IMPG1_ENST00000369950.3_Missense_Mutation_p.S147F			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	147					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GTGCTCCTGGGAATTGCTGAA	0.527000													35	56					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152782813	152782813	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152782813G>A	ENST00000367255.5	-	21	2914	c.2313C>T	c.(2311-2313)caC>caT	p.H771H	SYNE1_ENST00000413186.2_Silent_p.H771H|SYNE1_ENST00000448038.1_Silent_p.H778H|SYNE1_ENST00000367253.4_Silent_p.H771H|SYNE1_ENST00000367248.3_Silent_p.H761H|SYNE1_ENST00000423061.1_Silent_p.H778H|SYNE1_ENST00000265368.4_Silent_p.H771H|SYNE1_ENST00000341594.5_Silent_p.H778H|SYNE1_ENST00000495090.2_Silent_p.H338H	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	771					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGTAATGAGGTGTGCTGTCT	0.413000										HNSCC(10;0.0054)			46	61					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201355491	201355491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201355491G>A	ENST00000391967.2	-	3	1299	c.998C>T	c.(997-999)gCc>gTc	p.A333V	LAD1_ENST00000367313.3_Missense_Mutation_p.A347V	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	333						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						GAGGCGGGAGGCCACAGTCGG	0.667000													4	10					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360233	27360233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27360233C>T	ENST00000335524.3	-	3	1490	c.965G>A	c.(964-966)gGg>gAg	p.G322E		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	322										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCCTGAGGCCCTGCTTCCTT	0.672000													22	69					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52946817	52946817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52946817C>T	ENST00000267119.5	-	1	114	c.45G>A	c.(43-45)ggG>ggA	p.G15G		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	15	Gly-rich.|Head.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CACTGAAGCCCCCCTTGGCGG	0.617000													40	98					0	0	1	0	0
RBM14	10432	broad.mit.edu	37	11	66392364	66392364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66392364C>T	ENST00000310137.4	+	2	1156	c.1017C>T	c.(1015-1017)gcC>gcT	p.A339A	RBM14_ENST00000409738.4_Intron|RBM4_ENST00000503028.2_Intron|RBM14-RBM4_ENST00000412278.2_Intron|RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000514361.3_Intron|RBM14_ENST00000393979.3_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	339	Ala-rich.|TRBP-interacting domain.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						CCTCCCTTGCCTCCTATGGTA	0.612000													36	90					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125403600	125403600	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:125403600G>A	ENST00000359704.2	+	8	1023	c.685G>A	c.(685-687)Gaa>Aaa	p.E229K	RNF217_ENST00000560949.1_Intron|RNF217_ENST00000368414.2_Intron|RNF217_ENST00000521654.2_Intron|RNF217_ENST00000275184.6_Intron	NM_152553.2	NP_689766.1	Q8TC41	RN217_HUMAN	ring finger protein 217	229					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		tacagttgaggaaattaagac	0.353000													6	9					0	0	1	0	0
IDE	3416	broad.mit.edu	37	10	94297234	94297234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:94297234G>A	ENST00000265986.6	-	2	228	c.172C>T	c.(172-174)Cct>Tct	p.P58S		NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	58					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTCTTCAGGAGACTTGGTA	0.388000													10	135					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640458	34640458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34640458C>T	ENST00000537011.1	+	3	771	c.389C>T	c.(388-390)tCt>tTt	p.S130F	NUTM1_ENST00000333756.4_Missense_Mutation_p.S102F|NUTM1_ENST00000438749.3_Missense_Mutation_p.S120F					NUT midline carcinoma, family member 1																		GCTGAGCCCTCTCAAACTCAG	0.577000													40	66					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52781635	52781635	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52781635G>A	ENST00000245457.5	+	1	523	c.369G>A	c.(367-369)acG>acA	p.T123T	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	123						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	GCCTGGCCACGATGCTCATGC	0.677000													29	84					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11117651	11117651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:11117651G>A	ENST00000304623.8	-	13	2377	c.2188C>T	c.(2188-2190)Cgc>Tgc	p.R730C	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.R393C|CTNND2_ENST00000511377.1_Missense_Mutation_p.R639C|CTNND2_ENST00000458100.2_Missense_Mutation_p.R297C|CTNND2_ENST00000359640.2_Missense_Mutation_p.R730C	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	730					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						ATCCTTCTGCGGGCCTCCTCT	0.542000													34	77					0	0	1	0	0
FAM131A	131408	broad.mit.edu	37	3	184062315	184062315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184062315C>T	ENST00000310585.4	+	3	1929	c.565C>T	c.(565-567)Ctc>Ttc	p.L189F	EIF2B5_ENST00000444495.1_Intron|FAM131A_ENST00000418281.1_Missense_Mutation_p.L97F|FAM131A_ENST00000453072.1_Missense_Mutation_p.L135F|FAM131A_ENST00000383847.2_Missense_Mutation_p.L220F|FAM131A_ENST00000450976.1_Missense_Mutation_p.L135F|FAM131A_ENST00000340957.5_Missense_Mutation_p.L135F			Q6UXB0	F131A_HUMAN	family with sequence similarity 131, member A	189						extracellular region				breast(1)|endometrium(1)|large_intestine(2)|lung(9)|skin(1)	14	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGGGCCGCACCTCCAGGACCT	0.632000													9	130					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55655605	55655605	+	Missense_Mutation	SNP	G	G	A	rs146327492		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55655605G>A	ENST00000449290.2	+	4	697	c.605G>A	c.(604-606)cGa>cAa	p.R202Q	TRIM51_ENST00000244891.3_Missense_Mutation_p.R59Q	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	202						intracellular	zinc ion binding										GAAAGGCTGCGAAAGGAGGGC	0.428000													20	80					0	0	1	0	0
LGI3	203190	broad.mit.edu	37	8	22006032	22006032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22006032G>A	ENST00000306317.2	-	8	1577	c.1288C>T	c.(1288-1290)Cgt>Tgt	p.R430C	LGI3_ENST00000424267.2_Missense_Mutation_p.R406C	NM_139278.2	NP_644807.1	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	430					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome		p.R430G(1)		endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	17				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CGGCCGGCACGAAAGTGTTTC	0.632000													11	24					0	0	1	0	0
CDKL2	8999	broad.mit.edu	37	4	76530724	76530724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76530724G>A	ENST00000429927.2	-	5	1340	c.637C>T	c.(637-639)Cat>Tat	p.H213Y	CDKL2_ENST00000307465.4_Missense_Mutation_p.H213Y	NM_003948.3	NP_003939.1	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2 (CDC2-related kinase)	213	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(2)|stomach(2)	22			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ATCATAATATGATATAGCTGA	0.368000													5	68					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212685	26212685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:26212685C>T	ENST00000379034.1	+	2	871	c.722C>T	c.(721-723)tCc>tTc	p.S241F		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	241	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						AACAGAACCTCCCAACATTTG	0.498000													33	14					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127484521	127484521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127484521C>T	ENST00000262461.2	+	12	2146	c.1957C>T	c.(1957-1959)Cgt>Tgt	p.R653C	SLC12A2_ENST00000343225.4_Missense_Mutation_p.R653C	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	653					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGAACCTCTTCGTGGCTACAT	0.323000													53	139					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75174037	75174037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:75174037G>A	ENST00000336926.6	-	27	2748	c.2722C>T	c.(2722-2724)Cat>Tat	p.H908Y	HIP1_ENST00000434438.2_Missense_Mutation_p.H857Y	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	908	I/LWEQ.|Important for actin binding (By similarity).				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCAATTTCATGAGAACACACC	0.527000			T	PDGFRB	CMML								15	44					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113283288	113283288	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113283288G>A	ENST00000362072.3	-	7	1472	c.1128C>T	c.(1126-1128)gcC>gcT	p.A376A	DRD2_ENST00000346454.3_Silent_p.A347A|DRD2_ENST00000542968.1_Silent_p.A376A|DRD2_ENST00000538967.1_Silent_p.A378A|DRD2_ENST00000355319.2_Silent_p.A378A|DRD2_ENST00000544518.1_Silent_p.A375A	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	376					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CGAGAACAATGGCGAGCATCT	0.582000													14	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062500	9062500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9062500C>T	ENST00000397910.4	-	3	25149	c.24946G>A	c.(24946-24948)Gaa>Aaa	p.E8316K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8318	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTCCAGGTTCTCTGCTTATG	0.488000													43	88					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34158556	34158556	+	Silent	SNP	G	G	A	rs142510996		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34158556G>A	ENST00000373381.4	-	25	4202	c.4026C>T	c.(4024-4026)atC>atT	p.I1342I	CSMD2_ENST00000373380.1_Silent_p.I215I|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1302	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTCTGCTTCGATGGTCCAGA	0.567000													19	175					0	0	1	0	0
RASGRP1	10125	broad.mit.edu	37	15	38803830	38803830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:38803830G>A	ENST00000310803.5	-	8	1118	c.941C>T	c.(940-942)tCg>tTg	p.S314L	RASGRP1_ENST00000558164.1_Missense_Mutation_p.S314L|RASGRP1_ENST00000450598.2_Missense_Mutation_p.S314L|RASGRP1_ENST00000561180.1_Missense_Mutation_p.S365L|RASGRP1_ENST00000559830.1_Missense_Mutation_p.S314L|RASGRP1_ENST00000539159.1_Missense_Mutation_p.S266L	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	314	Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding	p.S314L(2)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TGGGACATGCGAACTTGTCTC	0.493000													9	80					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76569600	76569600	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:76569600G>A	ENST00000307431.8	+	19	3296	c.2911G>A	c.(2911-2913)Gga>Aga	p.G971R	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.G899R|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.G923R|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.G975R|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	972	EGF-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						ATGCCGCAATGGAGGGAAATG	0.502000													13	30					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087697	9087697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9087697G>A	ENST00000397910.4	-	1	4321	c.4118C>T	c.(4117-4119)tCa>tTa	p.S1373L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1373	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGATTGGGTGAACTTGAGAT	0.468000													36	72					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46133190	46133190	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46133190G>A	ENST00000371383.2	-	4	1200	c.940C>T	c.(940-942)Caa>Taa	p.Q314*	ENPP5_ENST00000492313.1_5'UTR|ENPP5_ENST00000230565.3_Nonsense_Mutation_p.Q314*			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	314						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						ATGATTGGTTGAATTCGACTG	0.383000													69	145					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77378026	77378026	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77378026C>T	ENST00000451710.3	-	26	3798	c.3561G>A	c.(3559-3561)ctG>ctA	p.L1187L	TRPM6_ENST00000376864.4_Silent_p.L1187L|TRPM6_ENST00000361255.3_Silent_p.L1182L|TRPM6_ENST00000360774.1_Silent_p.L1187L|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Silent_p.L1182L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1187					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TCATTTCTTTCAGCTGGAAGT	0.463000													9	45					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55705875	55705875	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55705875C>T	ENST00000379906.2	+	3	687	c.432C>T	c.(430-432)atC>atT	p.I144I	SLC6A2_ENST00000414754.3_Silent_p.I144I|SLC6A2_ENST00000561820.1_Silent_p.I144I|SLC6A2_ENST00000568943.1_Silent_p.I144I|SLC6A2_ENST00000566163.1_Silent_p.I144I|SLC6A2_ENST00000567238.1_Silent_p.I39I|SLC6A2_ENST00000219833.8_Silent_p.I144I	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	144					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TCATCCTGATCGCCCTGTACG	0.607000													15	37					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60696263	60696263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60696263C>T	ENST00000005286.4	+	4	850	c.697C>T	c.(697-699)Cca>Tca	p.P233S	TMEM132A_ENST00000453848.2_Missense_Mutation_p.P233S	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	233						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GCAGGCCCTCCCAGTGGGGGG	0.701000													11	22					0	0	1	0	0
RFWD3	55159	broad.mit.edu	37	16	74662525	74662525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:74662525G>A	ENST00000361070.4	-	11	1891	c.1794C>T	c.(1792-1794)gcC>gcT	p.A598A	RFWD3_ENST00000571750.1_Silent_p.A598A	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	598					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						ATGCAGCTGAGGCAGCTCTGG	0.517000													56	152					0	0	1	0	0
ACAP3	116983	broad.mit.edu	37	1	1229502	1229502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1229502G>A	ENST00000354700.5	-	22	2419	c.2217C>T	c.(2215-2217)ccC>ccT	p.P739P	ACAP3_ENST00000353662.3_Silent_p.P664P	NM_030649.2	NP_085152.2	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	739					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			endometrium(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	14						CGTGGTGCAGGGGCGCCCGGC	0.711000													3	5					0	0	1	0	0
TRAF2	7186	broad.mit.edu	37	9	139815662	139815662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139815662C>T	ENST00000359662.3	+	9	1334	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F	TRAF2_ENST00000536468.1_Missense_Mutation_p.S378F|TRAF2_ENST00000247668.2_Missense_Mutation_p.S378F			Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	378	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		GCCATCTTCTCCCCAGGTGTG	0.597000													16	41					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4920274	4920274	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4920274C>T	ENST00000433855.1	+	1	1933	c.1067C>T	c.(1066-1068)tCc>tTc	p.S356F	KCNA6_ENST00000280684.3_Missense_Mutation_p.S356F	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	356						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						TTCAAGCTCTCCCGCCACTCC	0.637000										HNSCC(72;0.22)			7	27					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27321384	27321384	+	Silent	SNP	G	G	A	rs148009259		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27321384G>A	ENST00000407991.1	-	6	1184	c.576C>T	c.(574-576)ttC>ttT	p.F192F	CHRNA2_ENST00000520933.2_Silent_p.F192F|CHRNA2_ENST00000240132.2_Silent_p.F177F	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	192						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	TCTGCTGGTCGAAGGGGAAGA	0.567000													47	92					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23235850	23235850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23235850C>T	ENST00000285848.5	+	1	120	c.120C>T	c.(118-120)ttC>ttT	p.F40F		NM_005015.3	NP_005006.3	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	0					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding	p.F40F(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		AAAAGTGCTTCCTCTCGAGGG	0.547000													69	148					0	0	1	0	0
DYNAP	284254	broad.mit.edu	37	18	52262188	52262188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52262188G>A	ENST00000321600.1	+	2	200	c.154G>A	c.(154-156)Gac>Aac	p.D52N	DYNAP_ENST00000585973.1_Intron	NM_173629.1	NP_775900.1			dynactin associated protein																		ACATCCAAATGACCAAGAGGC	0.433000													37	71					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127638767	127638767	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127638767C>T	ENST00000508053.1	-	52	6789	c.5815G>A	c.(5815-5817)Gag>Aag	p.E1939K	FBN2_ENST00000262464.4_Missense_Mutation_p.E1939K			P35556	FBN2_HUMAN	fibrillin 2	1939	EGF-like 32; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGATGCCGCTCGCACTCATCA	0.348000													27	96					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179648883	179648883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179648883C>T	ENST00000589042.1	-	16	2913	c.2689G>A	c.(2689-2691)Gag>Aag	p.E897K	TTN_ENST00000342992.6_Missense_Mutation_p.E897K|TTN_ENST00000360870.5_Missense_Mutation_p.E897K|TTN_ENST00000591111.1_Missense_Mutation_p.E897K|TTN_ENST00000342175.6_Missense_Mutation_p.E851K|TTN_ENST00000359218.5_Missense_Mutation_p.E851K|TTN_ENST00000460472.2_Missense_Mutation_p.E851K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	897							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTCACCTCAACGCCAGCT	0.547000													37	91					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91827259	91827259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91827259G>A	ENST00000394232.1	+	11	1986	c.1516G>A	c.(1516-1518)Gag>Aag	p.E506K	SV2B_ENST00000545111.2_Missense_Mutation_p.E355K|SV2B_ENST00000330276.4_Missense_Mutation_p.E506K	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	506					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			AGACCTCTACGAGCACAAGTT	0.512000													34	334					0	0	1	0	0
ZNF71	58491	broad.mit.edu	37	19	57133340	57133340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57133340C>T	ENST00000328070.6	+	3	919	c.685C>T	c.(685-687)Ctc>Ttc	p.L229F		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	229						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GACTTCCTCTCTCACCCAGCA	0.642000													19	55					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110826298	110826298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110826298C>T	ENST00000375820.4	-	40	3575	c.3454G>A	c.(3454-3456)Gag>Aag	p.E1152K		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1152	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTGCCTGGCTCCCCTTTCTGG	0.587000													15	43					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059450	9059450	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9059450G>A	ENST00000397910.4	-	3	28199	c.27996C>T	c.(27994-27996)tcC>tcT	p.S9332S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9334	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCCTGGGATGGATGTTCTGC	0.498000													37	130					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234851403	234851403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234851403G>A	ENST00000355722.4	+	5	674	c.560G>A	c.(559-561)gGa>gAa	p.G187E	TRPM8_ENST00000324695.4_Intron|TRPM8_ENST00000409625.1_Missense_Mutation_p.G160E|TRPM8_ENST00000433712.2_Intron			Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	0	Epitope; activates specific cytotoxic T lymphocytes.					integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTACCGGTGGGACAGGAGGAG	0.572000													20	56					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116930446	116930446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116930446C>T	ENST00000356083.3	+	3	1002	c.611C>T	c.(610-612)cCg>cTg	p.P204L		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	204	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						AAGATGAACCCGCATGCAGTC	0.597000													20	51					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24440779	24440779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:24440779G>A	ENST00000383168.4	-	4	778	c.650C>T	c.(649-651)tCc>tTc	p.S217F	AQP4_ENST00000581374.1_Missense_Mutation_p.S195F|AQP4_ENST00000583022.1_5'UTR|AQP4-AS1_ENST00000579964.1_RNA|AQP4-AS1_ENST00000582605.1_RNA|AQP4_ENST00000440832.3_Missense_Mutation_p.S195F	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	217					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					AGGTCCAAAGGATCGGGCGGG	0.433000													11	197					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95748146	95748146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:95748146G>A	ENST00000311106.3	-	7	995	c.758C>T	c.(757-759)tCa>tTa	p.S253L	PCSK1_ENST00000508626.1_Missense_Mutation_p.S206L|PCSK1_ENST00000513085.1_5'UTR|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	253	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAATCCAATTGAACTGGCCTC	0.468000													20	56					0	0	1	0	0
SSBP2	23635	broad.mit.edu	37	5	80769541	80769541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:80769541C>T	ENST00000320672.4	-	8	758	c.548G>A	c.(547-549)gGa>gAa	p.G183E	SSBP2_ENST00000505980.1_Missense_Mutation_p.G163E|SSBP2_ENST00000515395.1_Missense_Mutation_p.G153E|SSBP2_ENST00000514493.1_Missense_Mutation_p.G153E|SSBP2_ENST00000509053.1_Missense_Mutation_p.G153E	NM_001256732.1|NM_001256733.1|NM_012446.3	NP_001243661.1|NP_001243662.1|NP_036578.2	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	183	Gly-rich.|Pro-rich.			MTPPRGMVPLGP -> NDSSKRNGCLRTTVLTPGLSL (in Ref. 2; AAD27781).	regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		GGGCACCATTCCTCTTGGAGG	0.403000													19	45					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1079966	1079966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1079966G>A	ENST00000313093.2	+	13	1783	c.1552G>A	c.(1552-1554)Gcg>Acg	p.A518T	HMHA1_ENST00000536472.1_Missense_Mutation_p.A358T|HMHA1_ENST00000590577.1_Missense_Mutation_p.A153T|HMHA1_ENST00000586866.1_Missense_Mutation_p.A522T|HMHA1_ENST00000590214.1_Missense_Mutation_p.A545T|HMHA1_ENST00000539243.2_Missense_Mutation_p.A534T|HMHA1_ENST00000543365.1_Missense_Mutation_p.A401T	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	518					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TATGCAGACGGCGCCGCTGCC	0.672000													52	105					0	0	1	0	0
CLEC6A	93978	broad.mit.edu	37	12	8610502	8610502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8610502G>A	ENST00000382073.3	+	2	226	c.40G>A	c.(40-42)Ggc>Agc	p.G14S		NM_001007033.1	NP_001007034.1	Q6EIG7	CLC6A_HUMAN	C-type lectin domain family 6, member A	14					defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)|large_intestine(2)|lung(7)	10	Lung SC(5;0.184)					AGAGAAAAGAGGCTGGTTGTC	0.483000													16	51					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469404	72469404	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:72469404G>A	ENST00000296776.5	+	1	383	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	112						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		CCCGGACTCGGAACAGACACC	0.517000													37	77					0	0	1	0	0
MTX1	4580	broad.mit.edu	37	1	155178747	155178747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155178747G>A	ENST00000368376.3	+	1	258	c.152G>A	c.(151-153)gGg>gAg	p.G51E	MTX1_ENST00000316721.4_Missense_Mutation_p.G51E	NM_002455.3	NP_002446.2	Q13505	MTX1_HUMAN	metaxin 1	51					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCGCCTTCAGGGGTTCGGGGC	0.721000													8	12					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90897947	90897947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90897947C>T	ENST00000354377.3	+	2	241	c.55C>T	c.(55-57)Cct>Tct	p.P19S	ZNF774_ENST00000379090.5_Missense_Mutation_p.P19S|ZNF774_ENST00000558115.1_Intron	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	19	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CTTAGAGAATCCTCTCCAGGA	0.438000													12	26					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117788850	117788850	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117788850G>A	ENST00000350763.4	-	26	6705	c.6294C>T	c.(6292-6294)cgC>cgT	p.R2098R	TNC_ENST00000535648.1_Silent_p.R1643R|TNC_ENST00000542877.1_Silent_p.R1735R|TNC_ENST00000423613.2_Silent_p.R1825R|TNC_ENST00000346706.3_Silent_p.R1552R|TNC_ENST00000537320.1_Silent_p.R1461R|TNC_ENST00000341037.4_Silent_p.R1916R|TNC_ENST00000345230.3_Silent_p.R1461R|TNC_ENST00000340094.3_Silent_p.R1734R	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2098	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TCAGCTTGTAGCGAGTCTTGG	0.562000													17	50					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113999705	113999705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113999705G>A	ENST00000429538.3	-	6	675	c.481C>T	c.(481-483)Ccc>Tcc	p.P161S	AC016683.6_ENST00000451179.1_RNA|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000333145.5_RNA|PAX8_ENST00000348715.5_Missense_Mutation_p.P161S|PAX8_ENST00000263335.7_Missense_Mutation_p.P161S|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000397647.3_Missense_Mutation_p.P161S|PAX8_ENST00000263334.5_Missense_Mutation_p.P161S|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000422956.1_RNA	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	161					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity	p.P161S(1)	PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						GCTGAGCTGGGGACTGCAGTG	0.642000			T	PPARG	follicular thyroid		Thyroid dysgenesis						13	15					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71575494	71575494	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:71575494C>T	ENST00000304743.2	+	34	6921	c.6475C>T	c.(6475-6477)Cga>Tga	p.R2159*	PCNX_ENST00000556272.1_3'UTR|PCNX_ENST00000439984.3_Nonsense_Mutation_p.R2048*|PCNX_ENST00000238570.5_Nonsense_Mutation_p.R2087*	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	2159	Ser-rich.					integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GATATCGCTTCGAAACTTGCC	0.562000													10	65					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167689675	167689675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167689675G>A	ENST00000519204.1	+	28	7940	c.7822G>A	c.(7822-7824)Gag>Aag	p.E2608K	TENM2_ENST00000545108.1_Missense_Mutation_p.E2728K|TENM2_ENST00000518659.1_Missense_Mutation_p.E2729K|TENM2_ENST00000520394.1_Missense_Mutation_p.E2490K|TENM2_ENST00000403607.2_Missense_Mutation_p.E2553K					teneurin transmembrane protein 2																		GACTGAGGGCGAGAAGCAGCA	0.642000													4	13					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551092	248551092	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248551092C>T	ENST00000355728.2	+	1	183	c.183C>T	c.(181-183)ttC>ttT	p.F61F		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCATGTACTTCCTCCTCAGCC	0.488000													17	87					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52473641	52473641	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:52473641C>T	ENST00000219746.9	-	7	1511	c.1227G>A	c.(1225-1227)tcG>tcA	p.S409S	TOX3_ENST00000407228.3_Silent_p.S404S	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	409					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						CCCCAATGTTCGAGGGCATGT	0.542000													50	114					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395100	49395100	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49395100G>A	ENST00000419783.1	-	2	654	c.333C>T	c.(331-333)ctC>ctT	p.L111L	GPX1_ENST00000419349.1_3'UTR|GPX1_ENST00000496791.1_5'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	111					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	ACTTCTCGAAGAGCATGAAGT	0.617000													14	87					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113943595	113943595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113943595C>T	ENST00000245796.6	+	5	1586	c.1391C>T	c.(1390-1392)tCg>tTg	p.S464L	PSD4_ENST00000441564.2_Missense_Mutation_p.S436L	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	464					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCCCTGCATCGTCCCAGGAG	0.617000													14	38					0	0	1	0	0
C18orf25	147339	broad.mit.edu	37	18	43796276	43796276	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43796276C>T	ENST00000282059.6	+	2	804	c.430C>T	c.(430-432)Cga>Tga	p.R144*	C18orf25_ENST00000321319.6_Nonsense_Mutation_p.R144*	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	144										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						TAGGCGGTCCCGATCTGAAAG	0.532000													7	100					0	0	1	0	0
ING4	51147	broad.mit.edu	37	12	6761495	6761495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6761495G>A	ENST00000341550.4	-	6	633	c.587C>T	c.(586-588)aCc>aTc	p.T196I	ING4_ENST00000412586.2_Missense_Mutation_p.T194I|ING4_ENST00000423703.2_Intron|ING4_ENST00000486287.1_Intron|ING4_ENST00000444704.2_Missense_Mutation_p.T173I|ING4_ENST00000446105.2_Missense_Mutation_p.T193I|ING4_ENST00000396807.4_Missense_Mutation_p.T197I			Q9UNL4	ING4_HUMAN	inhibitor of growth family, member 4	197					apoptosis|cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell proliferation|negative regulation of growth|negative regulation of transcription, DNA-dependent|positive regulation of apoptosis	histone acetyltransferase complex	protein binding|transcription coactivator activity|zinc ion binding			central_nervous_system(3)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)	10						AAGGCAATAGGTGGGTTCGTT	0.522000													35	99					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91404608	91404608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:91404608G>A	ENST00000370440.1	-	3	2520	c.2303C>T	c.(2302-2304)tCa>tTa	p.S768L	ZNF644_ENST00000467231.1_Intron|ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.S768L|ZNF644_ENST00000347275.5_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	768					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGAATTTAATGAACTAGCTTC	0.328000													49	78					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505206	37505206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37505206G>A	ENST00000374660.1	+	38	3255	c.3156G>A	c.(3154-3156)atG>atA	p.M1052I	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.M933I|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.M933I			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1055						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CAGGAAAAATGGAACAAATGA	0.333000													23	69					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380880	56380880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56380880C>T	ENST00000526538.1	-	1	98	c.99G>A	c.(97-99)gcG>gcA	p.A33A		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						TTAGGTAGATCGCAAGGAATA	0.493000													48	76					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206869639	206869639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206869639G>A	ENST00000403263.1	-	11	2941	c.2537C>T	c.(2536-2538)cCc>cTc	p.P846L		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	846					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						TGTTGTGTGGGGAGAGGTGAT	0.517000													13	128					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31536324	31536324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31536324C>T	ENST00000215885.3	-	1	269	c.17G>A	c.(16-18)gGg>gAg	p.G6E		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	6					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						CCCAAACAGCCCTGCCTGAAC	0.677000													28	68					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149361299	149361299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149361299G>A	ENST00000286298.4	+	3	2411	c.2143G>A	c.(2143-2145)Gcg>Acg	p.A715T		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	715	STAS.		A -> V (in AO2).			integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGTGTATGAAGCGATGGCTTT	0.403000													19	94					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93148206	93148206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93148206C>T	ENST00000298050.3	+	13	1664	c.1564C>T	c.(1564-1566)Ccc>Tcc	p.P522S	CCDC67_ENST00000525646.1_Missense_Mutation_p.P264S	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	522										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TACAATGCCTCCCTTGCCACC	0.408000													19	81					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39224440	39224440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39224440C>T	ENST00000333039.2	-	2	825	c.702G>A	c.(700-702)aaG>aaA	p.K234K		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	234						integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					GCTGGTCCATCTTGGAGTGTA	0.657000													8	19					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7830562	7830562	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7830562G>A	ENST00000327325.5	+	4	371	c.253G>A	c.(253-255)Gag>Aag	p.E85K	CLEC4M_ENST00000334806.5_Missense_Mutation_p.E57K|CLEC4M_ENST00000359059.5_Missense_Mutation_p.E64K|CLEC4M_ENST00000597522.1_Missense_Mutation_p.E85K|CLEC4M_ENST00000596707.1_Missense_Mutation_p.E64K|CLEC4M_ENST00000248228.4_Missense_Mutation_p.E85K|CLEC4M_ENST00000596363.1_Missense_Mutation_p.E57K|CLEC4M_ENST00000394122.2_Missense_Mutation_p.E73K|CLEC4M_ENST00000595496.1_Missense_Mutation_p.E64K|CLEC4M_ENST00000357361.2_Missense_Mutation_p.E85K	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	85					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						GGAACAATCCGAGCAAGACGC	0.512000													37	100					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132010506	132010506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132010506G>A	ENST00000356920.5	+	13	1706	c.1612G>A	c.(1612-1614)Gct>Act	p.A538T	PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	538							ATP binding										AAATTTTATGGCTATCGAAGA	0.353000													9	145					0	0	1	0	0
MS4A6A	64231	broad.mit.edu	37	11	59940507	59940507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59940507G>A	ENST00000528851.1	-	6	785	c.645C>T	c.(643-645)ttC>ttT	p.F215F	MS4A6A_ENST00000323961.3_Silent_p.F215F|MS4A6A_ENST00000412309.2_Silent_p.F243F|MS4A6A_ENST00000420732.2_3'UTR|MS4A6A_ENST00000426738.2_Silent_p.F170F|MS4A6A_ENST00000529054.1_Silent_p.F243F|MS4A6A_ENST00000530839.1_Silent_p.F215F|MS4A6A_ENST00000533023.1_3'UTR			Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member 6A	215						integral to membrane	receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCACCCCAGGGAAGTCAGAGT	0.507000													31	165					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156747679	156747679	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156747679C>T	ENST00000347377.6	+	15	1971	c.1540C>T	c.(1540-1542)Cga>Tga	p.R514*	CYFIP2_ENST00000377576.3_Nonsense_Mutation_p.R514*|CYFIP2_ENST00000318218.6_Nonsense_Mutation_p.R514*|CYFIP2_ENST00000541131.1_Nonsense_Mutation_p.R439*|CYFIP2_ENST00000522463.1_Nonsense_Mutation_p.R318*|CYFIP2_ENST00000521420.1_Nonsense_Mutation_p.R488*|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Nonsense_Mutation_p.R188*	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	514					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACAGGCAATTCGAAAGACCAT	0.532000													24	46					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101348054	101348054	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101348054C>T	ENST00000534062.1	-	1	3130	c.3072G>A	c.(3070-3072)agG>agA	p.R1024R		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	1024										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TCGATGGATCCCTGGGGAATC	0.577000													3	11					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76437211	76437211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76437211C>T	ENST00000389840.5	-	72	11681	c.11557G>A	c.(11557-11559)Gag>Aag	p.E3853K	DNAH17_ENST00000586052.1_Intron|DNAH17_ENST00000585328.1_Missense_Mutation_p.E3862K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CTGCTCTCCTCGTAGGACTTA	0.557000													16	29					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182517	100182517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100182517C>T	ENST00000554176.1	+	4	1095	c.429C>T	c.(427-429)ttC>ttT	p.F143F	CYP46A1_ENST00000423126.2_Silent_p.F199F|CYP46A1_ENST00000261835.3_Silent_p.F296F			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	296					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				TGGACAACTTCGTCACCTTCT	0.542000													32	63					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872281	51872281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51872281G>A	ENST00000371497.5	+	2	3171	c.2284G>A	c.(2284-2286)Gat>Aat	p.D762N	TSHZ2_ENST00000603338.2_Missense_Mutation_p.D759N|TSHZ2_ENST00000329613.6_Missense_Mutation_p.D759N	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	762					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TGAGAACAGCGATCAGCCCAT	0.532000													12	95					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883384	228883384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228883384C>T	ENST00000392056.3	-	7	2232	c.2186G>A	c.(2185-2187)cGg>cAg	p.R729Q	SPHKAP_ENST00000344657.5_Missense_Mutation_p.R729Q	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	729						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCACCAAGCCGTACAATATG	0.453000													39	123					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23809268	23809268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23809268C>T	ENST00000354639.3	+	13	2001	c.1537C>T	c.(1537-1539)Cta>Tta	p.L513L	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Silent_p.L536L|STK31_ENST00000355870.3_Silent_p.L536L|STK31_ENST00000428484.1_Silent_p.L513L	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	536							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GGTTTTTGACCTATCTGTGGA	0.363000													10	184					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24511603	24511603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:24511603G>A	ENST00000264463.4	-	6	1342	c.835C>T	c.(835-837)Ctt>Ttt	p.L279F		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	279	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GAGGATTCAAGAACTCGAAGA	0.423000										HNSCC(23;0.051)			10	44					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735076	55735076	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55735076G>A	ENST00000312345.2	-	1	914	c.864C>T	c.(862-864)atC>atT	p.I288I		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					ATGCCACCATGATATCTTTGT	0.333000													12	54					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794954	126794954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126794954C>T	ENST00000373615.4	+	5	1928	c.1189C>T	c.(1189-1191)Ccc>Tcc	p.P397S		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	397				GHEPHSPSQTTLTNLF -> AMSLTAPHKRLLPTFSNDSQP PHPTISLKKKLSLV (in Ref. 1; AAB08752).		nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						GCCTCACAGCCCCTCACAAAC	0.493000													23	61					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40913356	40913356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40913356C>T	ENST00000346991.5	+	11	1362	c.972C>T	c.(970-972)tcC>tcT	p.S324S	CASC5_ENST00000399668.2_Silent_p.S298S|CASC5_ENST00000527044.1_3'UTR			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	324	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TTCCCACATCCAGTGAGACCA	0.363000													19	64					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227983445	227983445	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227983445T>C	ENST00000396625.3	-	7	612	c.405A>G	c.(403-405)aaA>aaG	p.K135K	COL4A4_ENST00000329662.7_Silent_p.K135K	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	135	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCATACCAGGTTTGCCTCTGG	0.493000													29	67					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11204731	11204731	+	Missense_Mutation	SNP	G	G	A	rs17848545	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11204731G>A	ENST00000361445.4	-	34	4922	c.4846C>T	c.(4846-4848)Cgc>Tgc	p.R1616C	MTOR-AS1_ENST00000445982.1_RNA|MTOR_ENST00000495435.1_5'UTR|MTOR-AS1_ENST00000420480.1_RNA	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1616	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CAGATCTGGCGGATGATCTCT	0.582000													20	52					0	0	1	0	0
PLAC9	219348	broad.mit.edu	37	10	81903997	81903997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81903997G>A	ENST00000372263.3	+	3	223	c.181G>A	c.(181-183)Gat>Aat	p.D61N	PLAC9_ENST00000372270.2_Missense_Mutation_p.D19N|PLAC9_ENST00000372267.2_Intron	NM_001012973.1	NP_001012991.1	Q5JTB6	PLAC9_HUMAN	placenta-specific 9	61						extracellular region				kidney(1)|ovary(1)	2	Prostate(51;0.0095)|all_epithelial(25;0.175)		Colorectal(32;0.109)			GAAGACCGTGGATCACCTGGG	0.612000											OREG0020321	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	65					0	0	1	0	0
BPIFA2	140683	broad.mit.edu	37	20	31763243	31763243	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31763243A>G	ENST00000253362.2	+	5	587	c.441A>G	c.(439-441)aaA>aaG	p.K147K	BPIFA2_ENST00000354932.5_Silent_p.K147K			Q96DR5	SPLC2_HUMAN	BPI fold containing family A, member 2	147						extracellular region	lipid binding										TCAACCTGAAAGCCTCCTTGG	0.537000													50	126					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102743580	102743580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102743580G>A	ENST00000210633.3	+	14	2302	c.2224G>A	c.(2224-2226)Gag>Aag	p.E742K	MRPL43_ENST00000342071.1_Intron|SEMA4G_ENST00000370250.4_Missense_Mutation_p.E737K|MRPL43_ENST00000318325.2_Intron|MRPL43_ENST00000299179.5_Intron|RP11-108L7.4_ENST00000447344.1_RNA|MRPL43_ENST00000370241.3_Intron|SEMA4G_ENST00000517724.1_Intron|MRPL43_ENST00000370242.4_Intron			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	737					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		GTGTCCTGGAGAGGAAGATGA	0.672000													5	9					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183586769	183586769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:183586769C>T	ENST00000264065.6	+	5	800	c.385C>T	c.(385-387)Cct>Tct	p.P129S	DNAJC10_ENST00000469118.1_3'UTR|DNAJC10_ENST00000537515.1_Missense_Mutation_p.P129S	NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	129					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGATGATGATCCTGAAATCAT	0.259000													43	98					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32030581	32030581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:32030581G>A	ENST00000360311.4	+	2	559	c.10G>A	c.(10-12)Gag>Aag	p.E4K		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						CATGTTACGTGAGGAAGCAGC	0.453000													29	88					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151115019	151115019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151115019G>A	ENST00000341697.3	-	3	1770	c.79C>T	c.(79-81)Ccc>Tcc	p.P27S				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	27						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGGTCCTGGGGAAAGGCGGCC	0.607000													16	22					0	0	1	0	0
TTYH2	94015	broad.mit.edu	37	17	72249256	72249256	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72249256C>T	ENST00000441391.2	+	6	1545	c.333C>T	c.(331-333)ccC>ccT	p.P111P	TTYH2_ENST00000269346.4_Silent_p.P432P|TTYH2_ENST00000529107.1_Silent_p.P411P	NM_052869.1	NP_443101.1	Q9BSA4	TTYH2_HUMAN	tweety family member 2	432						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						ATGATGACCCCTTTAACCCCC	0.582000													56	193					0	0	1	0	0
YTHDF1	54915	broad.mit.edu	37	20	61834932	61834932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61834932G>A	ENST00000370339.3	-	4	701	c.360C>T	c.(358-360)ttC>ttT	p.F120F	YTHDF1_ENST00000370334.4_Intron|YTHDF1_ENST00000370333.4_Silent_p.F70F	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	120										NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						GGAAAAAATTGAACCTGTGCT	0.542000													23	64					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880804	142880804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142880804C>T	ENST00000446620.1	+	1	293	c.293C>T	c.(292-294)tCa>tTa	p.S98L		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	98					sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.S98*(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					ACCATCAGCTCAACCTCCCTA	0.388000													46	116					0	0	1	0	0
C1orf51	148523	broad.mit.edu	37	1	150259114	150259114	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150259114C>T	ENST00000290363.5	+	5	1355	c.906C>T	c.(904-906)ccC>ccT	p.P302P	C1orf51_ENST00000369094.1_Silent_p.P214P|C1orf51_ENST00000369095.1_Silent_p.P302P	NM_144697.2	NP_653298.1	Q8N365	CA051_HUMAN	chromosome 1 open reading frame 51	302										endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(2)	10	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGTGCAACCCTTCACCCACT	0.557000													17	168					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38958423	38958423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38958423G>A	ENST00000355481.4	+	25	3483	c.3352G>A	c.(3352-3354)Gag>Aag	p.E1118K	RYR1_ENST00000359596.3_Missense_Mutation_p.E1118K|RYR1_ENST00000360985.3_Missense_Mutation_p.E1118K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1118	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGGAGCTGACGAGCTGGCCTA	0.632000													22	50					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31434475	31434475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31434475G>A	ENST00000389202.2	+	24	2870	c.2821G>A	c.(2821-2823)Gat>Aat	p.D941N		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	941					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TGCAACCTCCGATGAGAAGAA	0.498000													12	47					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242755720	242755720	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242755720C>T	ENST00000391969.2	+	3	750	c.39C>T	c.(37-39)ttC>ttT	p.F13F	NEU4_ENST00000405370.1_Silent_p.F13F|NEU4_ENST00000404257.1_Silent_p.F25F|NEU4_ENST00000407683.1_Silent_p.F13F|NEU4_ENST00000325935.6_Silent_p.F26F	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	13						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CAGTGCTCTTCGAGCGGGAGA	0.697000													9	41					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48625280	48625280	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:48625280C>T	ENST00000297423.4	+	15	2418	c.2034C>T	c.(2032-2034)gtC>gtT	p.V678V	SPIDR_ENST00000541342.1_Silent_p.V608V|SPIDR_ENST00000517693.1_Silent_p.V153V|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000518074.1_Silent_p.V618V	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		TGACCGATGTCACTCTGCAAA	0.498000													11	111					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390352	8390352	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8390352C>T	ENST00000471889.1	+	5	1184	c.799C>T	c.(799-801)Cga>Tga	p.R267*	SLC45A1_ENST00000377479.2_Nonsense_Mutation_p.R301*|SLC45A1_ENST00000289877.8_Nonsense_Mutation_p.R267*			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	267					carbohydrate transport	integral to membrane	symporter activity	p.R267*(1)		central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGGACAGCTCCGAGTCATTTA	0.637000													39	119					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49654524	49654524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49654524C>T	ENST00000249601.4	-	10	2303	c.2007G>A	c.(2005-2007)agG>agA	p.R669R	ARHGAP22_ENST00000417912.2_Silent_p.R685R|ARHGAP22_ENST00000477708.2_Silent_p.R502R|ARHGAP22_ENST00000374170.1_Silent_p.R510R|ARHGAP22_ENST00000417247.2_Silent_p.R579R|ARHGAP22_ENST00000374172.1_Silent_p.R560R|ARHGAP22_ENST00000435790.2_Silent_p.R675R	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	669					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						ACAGCTGGTTCCTCCTCTCCG	0.512000													47	90					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160094972	160094972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160094972C>T	ENST00000361216.3	+	7	766	c.677C>T	c.(676-678)tCc>tTc	p.S226F	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Missense_Mutation_p.S226F	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	226					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CAGACCCGCTCCCCCGAGTTC	0.552000													27	53					0	0	1	0	0
LIAS	11019	broad.mit.edu	37	4	39465209	39465209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39465209C>T	ENST00000261434.3	+	4	495	c.377C>T	c.(376-378)gCc>gTc	p.A126V	LIAS_ENST00000340169.2_Missense_Mutation_p.A126V|LIAS_ENST00000515061.1_3'UTR|LIAS_ENST00000513731.1_Intron|LIAS_ENST00000381846.1_Missense_Mutation_p.A126V	NM_006859.2	NP_006850.2	O43766	LIAS_HUMAN	lipoic acid synthetase	126					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)|ovary(2)	12					Lipoic Acid(DB00166)	TATGCCACCGCCACAGCCACG	0.458000													11	34					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54308037	54308037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54308037C>T	ENST00000545554.1	+	1	2937	c.2937C>T	c.(2935-2937)gcC>gcT	p.A979A	UNC13C_ENST00000537900.1_Silent_p.A979A|UNC13C_ENST00000260323.11_Silent_p.A979A			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	979					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CTTTAAGGGCCTATAAAAAGC	0.383000													4	11					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48463602	48463602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48463602G>A	ENST00000358536.4	-	6	1701	c.1432C>T	c.(1432-1434)Cct>Tct	p.P478S	PLXNB1_ENST00000296440.6_Missense_Mutation_p.P478S|PLXNB1_ENST00000358459.4_Missense_Mutation_p.P478S|PLXNB1_ENST00000456774.1_Missense_Mutation_p.P478S|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	478	Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAAGCCACAGGAACCTTCAGA	0.592000													21	33					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15964870	15964870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:15964870G>A	ENST00000268712.3	-	37	5983	c.5726C>T	c.(5725-5727)cCt>cTt	p.P1909L	NCOR1_ENST00000395851.1_Intron|NCOR1_ENST00000395857.3_Missense_Mutation_p.P493L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1909	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TTTTGGAGGAGGCCCTTTATC	0.463000													22	154					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151123529	151123529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151123529G>A	ENST00000370328.3	-	9	1218	c.1165C>T	c.(1165-1167)Cgt>Tgt	p.R389C	GABRE_ENST00000483564.1_5'UTR|GABRE_ENST00000370325.1_3'UTR	NM_004961.3	NP_004952.2	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	389					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GCACGGGTACGGGCATGGGCA	0.547000													3	6					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531888	92531888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92531888G>A	ENST00000298047.6	+	9	5726	c.5709G>A	c.(5707-5709)ctG>ctA	p.L1903L	FAT3_ENST00000525166.1_Silent_p.L1753L|FAT3_ENST00000409404.2_Silent_p.L1903L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1903	Cadherin 17.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGAGGTTCTGAAAGTTAGTG	0.428000										TCGA Ovarian(4;0.039)			10	35					0	0	1	0	0
GBGT1	26301	broad.mit.edu	37	9	136030652	136030652	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136030652G>A	ENST00000372040.3	-	6	583	c.272C>T	c.(271-273)tCc>tTc	p.S91F	RALGDS_ENST00000542690.1_Silent_p.L103L|GBGT1_ENST00000472281.1_5'UTR|GBGT1_ENST00000372038.3_Silent_p.L103L|GBGT1_ENST00000540636.1_Missense_Mutation_p.S74F|GBGT1_ENST00000372043.3_Missense_Mutation_p.S91F					globoside alpha-1,3-N-acetylgalactosaminyltransferase 1											breast(2)|endometrium(1)|kidney(4)|lung(2)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		GGTTCCCTCGGAGACGATGGG	0.617000													10	26					0	0	1	0	0
AQP10	89872	broad.mit.edu	37	1	154296247	154296247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154296247C>T	ENST00000484864.1	+	5	708	c.672C>T	c.(670-672)ttC>ttT	p.F224F	AQP10_ENST00000355197.4_3'UTR|AQP10_ENST00000324978.3_Silent_p.F224F			Q96PS8	AQP10_HUMAN	aquaporin 10	224					response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity	p.F224F(1)		central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|stomach(2)|upper_aerodigestive_tract(1)	23	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CACGTCTCTTCACCTACGTGG	0.627000													13	48					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113924290	113924290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:113924290G>A	ENST00000348367.4	-	13	1497	c.1300C>T	c.(1300-1302)Cct>Tct	p.P434S	GPAM_ENST00000423155.1_Missense_Mutation_p.P434S|GPAM_ENST00000369425.1_Missense_Mutation_p.P434S			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	434					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TACCTTGAAGGAAGTATAGCT	0.358000													14	46					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97158976	97158976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:97158976C>T	ENST00000524981.3	+	27	3614	c.3614C>T	c.(3613-3615)tCg>tTg	p.S1205L				Q6ZTY8	CL063_HUMAN		1179										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						CTTTTGTCTTCGTATACAGAT	0.289000													26	73					0	0	1	0	0
NOL9	79707	broad.mit.edu	37	1	6610651	6610651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6610651G>A	ENST00000377705.5	-	2	453	c.421C>T	c.(421-423)Cgt>Tgt	p.R141C		NM_024654.4	NP_078930.3	Q5SY16	NOL9_HUMAN	nucleolar protein 9	141					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(2)|urinary_tract(1)	19	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGTCACACGACAGATCCCA	0.413000													21	58					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251824	25251824	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:25251824C>T	ENST00000328086.7	-	7	3020	c.2217G>A	c.(2215-2217)caG>caA	p.Q739Q		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	739					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		CAAAAGGCCTCTGATGCACAA	0.488000													23	77					0	0	1	0	0
AC010731.4	0	broad.mit.edu	37	2	207509150	207509150	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207509150C>T	ENST00000543490.1	+	0	365																											GTGGAAACCTCGCGTTTCCAA	0.488000													5	35					0	0	1	0	0
HLA-DRA	3122	broad.mit.edu	37	6	32411228	32411228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32411228C>T	ENST00000395388.2	+	3	704	c.595C>T	c.(595-597)Ctt>Ttt	p.L199F	HLA-DRA_ENST00000374982.5_Missense_Mutation_p.L174F	NM_019111.4	NP_061984.2	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR alpha	199	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19						GGATGAGCCTCTTCTCAAGCA	0.493000									T-cell Lymphoma, (Cutaneous) , Familial Clustering of;Kaposi Sarcoma, Familial Clustering of				21	90					0	0	1	0	0
SIRT2	22933	broad.mit.edu	37	19	39384091	39384091	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39384091G>A	ENST00000249396.7	-	4	490	c.189C>T	c.(187-189)acC>acT	p.T63T	SIRT2_ENST00000358931.5_Silent_p.T63T|SIRT2_ENST00000392081.2_Silent_p.T26T	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	63					cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			CCCCTTCCAAGGTCAGCTCGT	0.612000													13	28					0	0	1	0	0
ZC3H11A	9877	broad.mit.edu	37	1	203819693	203819693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203819693C>T	ENST00000545588.1	+	15	5817	c.1990C>T	c.(1990-1992)Ccc>Tcc	p.P664S	ZC3H11A_ENST00000367214.1_Missense_Mutation_p.P664S|ZC3H11A_ENST00000367212.3_Missense_Mutation_p.P664S|ZC3H11A_ENST00000332127.4_Missense_Mutation_p.P664S|ZC3H11A_ENST00000367210.1_Missense_Mutation_p.P664S	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	664							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTGTCATCCCCCAAATTGGC	0.488000													38	124					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736879	140736879	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140736879C>T	ENST00000571252.1	+	1	2112	c.2112C>T	c.(2110-2112)ttC>ttT	p.F704F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGCGTCTTCCTGGCTTTTG	0.612000													22	51					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42797233	42797233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42797233C>T	ENST00000314073.5	+	6	1338	c.1162C>T	c.(1162-1164)Cat>Tat	p.H388Y	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.H388Y					GLTSCR1-like																		TATTGTTATTCATTCCCCCAT	0.488000													63	287					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103442133	103442133	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103442133G>A	ENST00000361246.2	-	11	1683	c.1395C>T	c.(1393-1395)acC>acT	p.T465T		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	465					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GCACGGTCTGGGTGGACTCTG	0.597000													12	221					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608595	4608595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4608595G>A	ENST00000312614.4	+	1	575	c.553G>A	c.(553-555)Gcc>Acc	p.A185T		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCTATCATAGCCATAACTCC	0.493000													37	87					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189590653	189590653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189590653G>A	ENST00000264731.3	+	10	1307	c.1218G>A	c.(1216-1218)agG>agA	p.R406R	TP63_ENST00000392461.3_Silent_p.R312R|TP63_ENST00000418709.2_Silent_p.R406R|TP63_ENST00000449992.1_Silent_p.R227R|TP63_ENST00000437221.1_Silent_p.R312R|TP63_ENST00000320472.5_Silent_p.R406R|TP63_ENST00000392463.2_Silent_p.R312R|TP63_ENST00000392460.3_Silent_p.R406R|TP63_ENST00000456148.1_Silent_p.R308R|TP63_ENST00000382063.4_Silent_p.R321R|TP63_ENST00000354600.5_Silent_p.R312R|TP63_ENST00000440651.2_Silent_p.R402R	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	406	Oligomerization.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CATAGGTGAGGGGCCGTGAGA	0.438000										HNSCC(45;0.13)			15	35					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58206895	58206895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58206895C>T	ENST00000377918.3	+	1	241	c.215C>T	c.(214-216)cCg>cTg	p.P72L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	72	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AACTCCGCACCGCACCTGCTG	0.687000													12	28					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51851266	51851266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51851266C>T	ENST00000453097.2	+	6	923	c.706C>T	c.(706-708)Cgc>Tgc	p.R236C	SLC4A8_ENST00000394856.1_Missense_Mutation_p.R183C|SLC4A8_ENST00000358657.3_Missense_Mutation_p.R263C|SLC4A8_ENST00000514353.3_Missense_Mutation_p.R183C|SLC4A8_ENST00000535225.2_Missense_Mutation_p.R183C	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	236					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TCCCATTGTTCGCTCCTTTGC	0.393000													24	85					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141336442	141336442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141336442C>T	ENST00000231484.3	-	1	2185	c.975G>A	c.(973-975)agG>agA	p.R325R		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	325	Cadherin 3.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCCAGGTCCCTTGCCTGAA	0.522000													25	56					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990342	63990342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:63990342C>T	ENST00000370657.4	-	4	1147	c.1114G>A	c.(1114-1116)Gac>Aac	p.D372N	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	372					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	TCTTTCCTGTCCTTGGAATAA	0.478000													52	149					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40714389	40714389	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40714389G>A	ENST00000373198.3	-	29	4252	c.4017C>T	c.(4015-4017)ttC>ttT	p.F1339F	PTPRT_ENST00000373187.1_Silent_p.F1317F|PTPRT_ENST00000373193.3_Silent_p.F1320F|PTPRT_ENST00000373201.1_Silent_p.F1307F|PTPRT_ENST00000373184.1_Silent_p.F1327F|PTPRT_ENST00000356100.2_Silent_p.F1326F|PTPRT_ENST00000373190.1_Silent_p.F1316F	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1317	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TACAGATGCGGAATATTCTGT	0.587000													6	91					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058235	11058235	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11058235C>T	ENST00000470054.1	-	0	412									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGTGTCGGCTCCTGCAGCACA	0.428000													12	134					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756466	56756466	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56756466C>T	ENST00000326855.2	+	1	120	c.78C>T	c.(76-78)atC>atT	p.I26I		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						TTTGGTGTATCCTCTTCATTG	0.393000													41	161					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57430138	57430138	+	Missense_Mutation	SNP	G	G	A	rs143613424	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57430138G>A	ENST00000442789.2	-	23	2589	c.2302C>T	c.(2302-2304)Cgg>Tgg	p.R768W	MYO1A_ENST00000544473.1_Missense_Mutation_p.R606W|MYO1A_ENST00000300119.3_Missense_Mutation_p.R768W	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	768	IQ 3.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						GCCTCTGACCGGAAATATTTG	0.468000													49	154					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226032	158226032	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158226032G>A	ENST00000289429.5	+	3	1097	c.564G>A	c.(562-564)ttG>ttA	p.L188L		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	188	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GTTTCATCTTGGGTCTTCTTG	0.463000													17	86					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	36007457	36007457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:36007457C>T	ENST00000297866.5	+	16	2801	c.2735C>T	c.(2734-2736)tCa>tTa	p.S912L		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	912										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GCATATTCCTCACTGGAATGT	0.353000													18	27					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169432736	169432736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169432736C>T	ENST00000261509.6	+	2	292	c.81C>T	c.(79-81)ttC>ttT	p.F27F	PALLD_ENST00000333488.4_5'UTR|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Silent_p.F27F	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	27					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CTGACTTCTTCCCGGGCCTTT	0.502000									Pancreatic Cancer, Familial Clustering of				18	69					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588260	247588260	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247588260G>A	ENST00000366497.2	+	4	2295	c.1515G>A	c.(1513-1515)atG>atA	p.M505I	NLRP3_ENST00000391828.3_Missense_Mutation_p.M505I|NLRP3_ENST00000336119.3_Missense_Mutation_p.M505I|NLRP3_ENST00000391827.2_Missense_Mutation_p.M505I|NLRP3_ENST00000348069.2_Missense_Mutation_p.M505I|NLRP3_ENST00000366496.2_Missense_Mutation_p.M505I|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	505	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCTGAGGATGAACCTGTTCC	0.502000													23	40					0	0	1	0	0
ZNF548	147694	broad.mit.edu	37	19	57910226	57910226	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57910226C>T	ENST00000366197.5	+	3	821	c.571C>T	c.(571-573)Cag>Tag	p.Q191*	ZNF548_ENST00000336128.7_Nonsense_Mutation_p.Q203*|AC003002.6_ENST00000600421.1_Intron|AC004076.7_ENST00000597410.1_Intron|AC003002.6_ENST00000596400.1_Intron	NM_152909.3	NP_690873.2	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGAAGCCTTTCAGACTGGACA	0.498000													23	74					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44019227	44019227	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44019227C>T	ENST00000359947.4	+	4	496	c.156C>T	c.(154-156)ttC>ttT	p.F52F	PTPRF_ENST00000372413.3_Silent_p.F52F|PTPRF_ENST00000372414.3_Silent_p.F52F|PTPRF_ENST00000438120.1_Silent_p.F52F	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	52	Ig-like C2-type 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TAGCCTCCTTCGTGTGCCAAG	0.562000													98	240					0	0	1	0	0
ESD	2098	broad.mit.edu	37	13	47355713	47355713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:47355713G>A	ENST00000378720.3	-	7	601	c.419C>T	c.(418-420)cCc>cTc	p.P140L	ESD_ENST00000495654.1_5'UTR|ESD_ENST00000378697.1_Missense_Mutation_p.P111L	NM_001984.1	NP_001975.1	P10768	ESTD_HUMAN	esterase D	140						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)	9		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	CATCCTTTGGGGATCCACTGG	0.353000													43	131					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69881775	69881775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:69881775G>A	ENST00000358913.5	+	2	1068	c.580G>A	c.(580-582)Gaa>Aaa	p.E194K	MYPN_ENST00000354393.2_Intron|MYPN_ENST00000540630.1_Missense_Mutation_p.E194K|MYPN_ENST00000373675.3_Missense_Mutation_p.E194K	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	194	Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						AGTTATGCAGGAAAACAGCTC	0.448000													21	74					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151134155	151134155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151134155C>T	ENST00000474524.1	+	41	6286	c.6248C>T	c.(6247-6249)tCg>tTg	p.S2083L	MED12L_ENST00000273432.4_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	2083	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			cagcagTCCTCGCAGTCCCAG	0.532000													21	71					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25008807	25008807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25008807G>A	ENST00000381989.3	-	31	4577	c.4472C>T	c.(4471-4473)tCc>tTc	p.S1491F		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1491					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		GGTAGTCCGGGACTGACTGCA	0.488000													6	68					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52521021	52521021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52521021G>A	ENST00000216286.5	-	4	785	c.786C>T	c.(784-786)atC>atT	p.I262I	NID2_ENST00000541773.1_Silent_p.I209I	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	262	NIDO.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					ACACTCCAGGGATCCCCAGGT	0.483000													8	42					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657090	143657090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143657090G>A	ENST00000392899.1	+	1	64	c.27G>A	c.(25-27)gtG>gtA	p.V9V		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					AGACTTGGGTGAGTGAATTTA	0.428000													45	132					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53185105	53185105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53185105C>T	ENST00000417996.2	-	7	1494	c.1420G>A	c.(1420-1422)Gcg>Acg	p.A474T	KRT3_ENST00000309505.3_Missense_Mutation_p.A474T	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	474	Coil 2.|Rod.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						TCATCCTTCGCCTGCTGTAGA	0.612000													42	80					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23809324	23809324	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23809324C>T	ENST00000354639.3	+	13	2057	c.1593C>T	c.(1591-1593)atC>atT	p.I531I	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Silent_p.I554I|STK31_ENST00000355870.3_Silent_p.I554I|STK31_ENST00000428484.1_Silent_p.I531I	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	554							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTGATGAAATCCTAGAGAAGA	0.373000													68	181					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224916	26224916	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:26224916G>A	ENST00000056233.3	+	4	1857	c.1598G>A	c.(1597-1599)aGa>aAa	p.R533K		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	533					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						GACACAGATAGAAACTTGAGC	0.428000													34	83					0	0	1	0	0
TEX19	400629	broad.mit.edu	37	17	80320289	80320289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80320289G>A	ENST00000333437.4	+	2	573	c.263G>A	c.(262-264)gGa>gAa	p.G88E		NM_207459.3	NP_997342.1	Q8NA77	TEX19_HUMAN	testis expressed 19	88						nucleus				breast(1)|endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	6						CAGAGCCCAGGACAGCCTGTG	0.647000													13	58					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087887	9087887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9087887G>A	ENST00000397910.4	-	1	4131	c.3928C>T	c.(3928-3930)Cct>Tct	p.P1310S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1310	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTCTCCAGGAGCTGTCATC	0.507000													24	65					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5541334	5541334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5541334G>A	ENST00000382368.3	-	3	689	c.566C>T	c.(565-567)cCc>cTc	p.P189L	FBXL18_ENST00000453700.3_Missense_Mutation_p.P189L	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	189									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GGTGCAGCAGGGCACCACGCC	0.662000													3	15					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155203216	155203216	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155203216T>C	ENST00000460012.1	-	22	3170	c.2813A>G	c.(2812-2814)aAc>aGc	p.N938S	PLCH1_ENST00000414191.1_Missense_Mutation_p.N938S|PLCH1_ENST00000340059.7_Missense_Mutation_p.N976S|PLCH1_ENST00000334686.6_Missense_Mutation_p.N938S|PLCH1_ENST00000447496.2_Missense_Mutation_p.N976S|PLCH1_ENST00000494598.1_Missense_Mutation_p.N956S			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	976					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCCAGAAGGTTTCTGTCAAC	0.468000													35	103					0	0	1	0	0
WWTR1	25937	broad.mit.edu	37	3	149290715	149290715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:149290715G>A	ENST00000465804.1	-	4	760	c.504C>T	c.(502-504)ctC>ctT	p.L168L	WWTR1_ENST00000360632.3_Silent_p.L168L|WWTR1_ENST00000467467.1_Silent_p.L168L	NM_001168278.1	NP_001161750.1	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	168					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	23			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CGGCAGGGTGGAGGTTCATAT	0.418000			T	CAMTA1	epitheliod hemangioendothelioma								39	82					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160050863	160050863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160050863C>T	ENST00000263635.6	+	17	3075	c.2838C>T	c.(2836-2838)ggC>ggT	p.G946G	TANC1_ENST00000454300.1_Silent_p.G840G	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	946						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CTCACCTTGGCCACGAGGAAG	0.557000													27	65					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250719	140250719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140250719C>T	ENST00000398640.2	+	1	2031	c.2031C>T	c.(2029-2031)gcC>gcT	p.A677A	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCAAAGGCCTCTTCCCGGA	0.652000													7	82					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74367329	74367329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74367329G>A	ENST00000290438.3	-	11	901	c.861C>T	c.(859-861)tcC>tcT	p.S287S		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	287										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						GGGGCGCCAGGGATGGGGGCT	0.552000													29	108					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207564903	207564903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207564903G>A	ENST00000452335.2	-	6	637	c.521C>T	c.(520-522)cCt>cTt	p.P174L	DYTN_ENST00000477734.1_5'UTR	NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	174						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		ACTTTCCACAGGGCACAGAGC	0.527000													35	79					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176011643	176011643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176011643G>A	ENST00000510636.1	+	19	2635	c.2361G>A	c.(2359-2361)ggG>ggA	p.G787G	CDHR2_ENST00000261944.5_Silent_p.G787G|CDHR2_ENST00000506348.1_Silent_p.G787G	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	787	Cadherin 7.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						ACCCCCAGGGGGGTGAGACCA	0.602000													13	125					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354074	57354074	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57354074C>T	ENST00000314922.3	-	2	637	c.561G>A	c.(559-561)ggG>ggA	p.G187G	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Silent_p.G187G	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	187					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TCATGAAGCCCCCATATCTCT	0.522000													53	129					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44087626	44087626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44087626C>T	ENST00000359947.4	+	34	6016	c.5676C>T	c.(5674-5676)taC>taT	p.Y1892Y	PTPRF_ENST00000422171.2_Silent_p.Y1251Y|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Silent_p.Y1883Y|PTPRF_ENST00000372414.3_Silent_p.Y1892Y|PTPRF_ENST00000438120.1_Silent_p.Y1883Y	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1892	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGCTGTGCTACCGTGCGGCCC	0.652000													30	81					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100623260	100623260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:100623260C>T	ENST00000317233.4	-	6	942	c.707G>A	c.(706-708)aGg>aAg	p.R236K	AFF3_ENST00000356421.2_Missense_Mutation_p.R261K|AFF3_ENST00000409236.1_Missense_Mutation_p.R236K|AFF3_ENST00000409579.1_Missense_Mutation_p.R261K	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	236					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GTCCATTGGCCTCACATACGC	0.577000													18	48					0	0	1	0	0
CLCF1	23529	broad.mit.edu	37	11	67133074	67133074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67133074C>T	ENST00000312438.7	-	3	408	c.211G>A	c.(211-213)Gag>Aag	p.E71K	AP003419.11_ENST00000543494.1_RNA|CLCF1_ENST00000528474.1_Missense_Mutation_p.E61K|CLCF1_ENST00000533438.1_Missense_Mutation_p.E61K	NM_013246.2	NP_037378.1	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1	71					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			endometrium(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			AAGTCTGGCTCGTTGAAAGGG	0.612000													31	82					0	0	1	0	0
SRPX2	27286	broad.mit.edu	37	X	99917296	99917296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:99917296G>A	ENST00000373004.3	+	4	715	c.287G>A	c.(286-288)cGa>cAa	p.R96Q		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	96	Sushi 1.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						CGGGGCTTTCGATTGATTGGA	0.537000													18	79					0	0	1	0	0
SHC2	25759	broad.mit.edu	37	19	430734	430734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:430734G>A	ENST00000264554.6	-	9	1123	c.1124C>T	c.(1123-1125)tCt>tTt	p.S375F		NM_012435.2	NP_036567.2	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing) transforming protein 2	375	CH1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol				endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTCTTAGAGAAGGAGATGG	0.647000													8	29					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996538	143996538	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143996538C>T	ENST00000323110.2	-	3	521	c.519G>A	c.(517-519)aaG>aaA	p.K173K		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	173			K -> R (in dbSNP:rs4539).		aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCACCTTCTTCTTCAGGGCCT	0.627000									Familial Hyperaldosteronism type I				3	19					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149449834	149449834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149449834G>A	ENST00000286301.3	-	9	1521	c.1230C>T	c.(1228-1230)ttC>ttT	p.F410F		NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	410	Ig-like C2-type 5.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	AGCCGTTGATGAATGTCCATA	0.572000													17	48					0	0	1	0	0
GSR	2936	broad.mit.edu	37	8	30567359	30567359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30567359G>A	ENST00000221130.5	-	3	484	c.394C>T	c.(394-396)Cca>Tca	p.P132S	GSR_ENST00000414019.1_Missense_Mutation_p.P89S|GSR_ENST00000541648.1_Missense_Mutation_p.P132S|GSR_ENST00000546342.1_Missense_Mutation_p.P132S|GSR_ENST00000537535.1_Missense_Mutation_p.P132S	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	132					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TCACAACTTGGAAAGCCATAA	0.363000													9	33					0	0	1	0	0
TRIM63	84676	broad.mit.edu	37	1	26393830	26393830	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26393830G>A	ENST00000374272.3	-	1	294	c.156C>T	c.(154-156)ttC>ttT	p.F52F	TRIM63_ENST00000483052.1_5'UTR	NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	52						cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CACTTACCTGGAAGATGTCAT	0.557000													12	27					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85696067	85696067	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:85696067G>A	ENST00000322366.6	-	29	5067	c.4660C>T	c.(4660-4662)Cga>Tga	p.R1554*	WDFY3_ENST00000295888.4_Nonsense_Mutation_p.R1554*			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1554						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GACATATCTCGAAGAGTCAGG	0.398000													47	99					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915289	119915289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:119915289G>A	ENST00000331113.4	+	1	1568	c.603G>A	c.(601-603)gcG>gcA	p.A201A		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	201					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CTGTCATCGCGAATGTGGTGG	0.572000													8	68					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4073527	4073527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:4073527C>T	ENST00000274673.3	-	6	687	c.284G>A	c.(283-285)gGa>gAa	p.G95E	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	95																	TATGGTACTTCCTTCATTAAG	0.299000													8	106					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58115674	58115674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58115674C>T	ENST00000332854.6	+	2	280	c.60C>T	c.(58-60)gcC>gcT	p.A20A	ZNF530_ENST00000597864.1_5'UTR	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGGATGTGGCCATTTACTTCT	0.507000													17	178					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440697	40440697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40440697C>T	ENST00000319592.4	-	4	923	c.214G>A	c.(214-216)Gag>Aag	p.E72K	RBM47_ENST00000381793.2_Missense_Mutation_p.E72K|RBM47_ENST00000381795.6_Missense_Mutation_p.E72K|RBM47_ENST00000295971.7_Missense_Mutation_p.E72K|RBM47_ENST00000514014.1_Missense_Mutation_p.E34K|RBM47_ENST00000515809.1_Intron			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	72	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						ACGAAGACCTCGCAGCCACGC	0.692000													11	30					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690654	33690654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33690654C>T	ENST00000394566.1	-	4	445	c.173G>A	c.(172-174)gGa>gAa	p.G58E	SLFN11_ENST00000308377.4_Missense_Mutation_p.G58E	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	58						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AATCACTCCTCCTCCTGAGTT	0.448000													60	116					0	0	1	0	0
MOS	4342	broad.mit.edu	37	8	57026446	57026446	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57026446C>T	ENST00000311923.1	-	1	95	c.96G>A	c.(94-96)gcG>gcA	p.A32A		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog	32							ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			GAAGCAGCTTCGCAGGTAGCT	0.701000													13	22					0	0	1	0	0
CLP1	10978	broad.mit.edu	37	11	57427291	57427291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57427291C>T	ENST00000533682.1	+	2	1068	c.343C>T	c.(343-345)Ccc>Tcc	p.P115S	CLP1_ENST00000302731.4_Missense_Mutation_p.P115S|CLP1_ENST00000525602.1_Missense_Mutation_p.P115S|CLP1_ENST00000529430.1_Missense_Mutation_p.P126S			Q92989	CLP1_HUMAN	cleavage and polyadenylation factor I subunit 1	115					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|stomach(1)	15						AGAGCGAGGTCCCCGAGTGAT	0.552000													14	42					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23328614	23328614	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23328614C>T	ENST00000597761.2	+	4	967	c.768C>T	c.(766-768)taC>taT	p.Y256Y		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						AAAAACCCTACCAATGTGAGA	0.333000													3	18					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131339657	131339657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131339657C>T	ENST00000372739.3	+	8	1067	c.957C>T	c.(955-957)gaC>gaT	p.D319D	SPTAN1_ENST00000372731.4_Silent_p.D319D|SPTAN1_ENST00000358161.5_Silent_p.D319D	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	319					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						CTGAGGCTGACCGCCTGCAAC	0.498000													33	67					0	0	1	0	0
RHPN1	114822	broad.mit.edu	37	8	144461624	144461624	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144461624C>T	ENST00000289013.6	+	8	992	c.891C>T	c.(889-891)tcC>tcT	p.S297S		NM_052924.2	NP_443156.2	Q8TCX5	RHPN1_HUMAN	rhophilin, Rho GTPase binding protein 1	297	BRO1.				signal transduction	intracellular				endometrium(1)|large_intestine(1)|lung(7)	9	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CACCTGCCTCCATGGCCCCCC	0.692000													3	9					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926806	1926806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1926806C>T	ENST00000399161.2	-	10	1482	c.735G>A	c.(733-735)cgG>cgA	p.R245R	MYT1L_ENST00000428368.2_Silent_p.R245R	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	245					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACTCACTTTTCCGACCCAGGT	0.458000													42	113					0	0	1	0	0
EXT2	2132	broad.mit.edu	37	11	44148446	44148446	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:44148446C>T	ENST00000395673.3	+	6	1175	c.1119C>T	c.(1117-1119)gtC>gtT	p.V373V	EXT2_ENST00000343631.3_Silent_p.V340V|EXT2_ENST00000533608.1_Silent_p.V340V|EXT2_ENST00000358681.4_Silent_p.V340V	NM_000401.3	NP_000392.3	Q93063	EXT2_HUMAN	exostosin glycosyltransferase 2	340					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|lung(17)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	32						CTGGCTGTGTCCCGGTTGTCA	0.498000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Hereditary Multiple Exostoses				37	110					0	0	1	0	0
UPK3A	7380	broad.mit.edu	37	22	45683229	45683229	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45683229C>T	ENST00000216211.4	+	3	417	c.385C>T	c.(385-387)Ctg>Ttg	p.L129L	UPK3A_ENST00000396082.2_Intron	NM_006953.3	NP_008884.1	O75631	UPK3A_HUMAN	uroplakin 3A	129					epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane				kidney(1)|large_intestine(1)|lung(2)|skin(1)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CTCACAGATCCTGAATGCCTA	0.612000													9	25					0	0	1	0	0
E2F3	1871	broad.mit.edu	37	6	20490515	20490515	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:20490515C>T	ENST00000346618.3	+	7	1318	c.1252C>T	c.(1252-1254)Cta>Tta	p.L418L	E2F3_ENST00000535432.1_Silent_p.L287L	NM_001949.4	NP_001940.1	O00716	E2F3_HUMAN	E2F transcription factor 3	418	Transactivation (Potential).				G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(3)	7	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			TCCTTCCAACCTAGAAGGACC	0.527000													28	79					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130282378	130282378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130282378G>A	ENST00000358511.6	+	2	562	c.531G>A	c.(529-531)atG>atA	p.M177I	COL6A6_ENST00000453409.2_Missense_Mutation_p.M177I	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	177	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TGAAGGCCATGGCCACGTCTC	0.463000													8	68					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073562	9073562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9073562C>T	ENST00000397910.4	-	3	14087	c.13884G>A	c.(13882-13884)ggG>ggA	p.G4628G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4630	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTAATAGCCCCCACAGACA	0.458000													19	62					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230162	39230162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39230162C>T	ENST00000340369.3	-	2	1003	c.775G>A	c.(775-777)Gag>Aag	p.E259K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.E259K	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	259							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGGATCTCCTCCCGGCATGCG	0.622000													37	91					0	0	1	0	0
ACOX3	8310	broad.mit.edu	37	4	8376785	8376785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8376785G>A	ENST00000356406.5	-	15	1825	c.1748C>T	c.(1747-1749)tCg>tTg	p.S583L	ACOX3_ENST00000413009.2_Missense_Mutation_p.S583L|ACOX3_ENST00000503233.1_Missense_Mutation_p.S583L	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	583					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						GGCCCGCAGCGAGGGCGGCAC	0.701000													3	3					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084368	152084368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152084368C>T	ENST00000368804.1	-	2	1324	c.1325G>A	c.(1324-1326)aGg>aAg	p.R442K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	442	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ctgctcgcgcctctcctgctc	0.692000													22	89					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63668267	63668267	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63668267C>T	ENST00000402010.2	+	10	1483	c.904C>T	c.(904-906)Cga>Tga	p.R302*	MARK2_ENST00000315032.8_Nonsense_Mutation_p.R302*|MARK2_ENST00000408948.3_Nonsense_Mutation_p.R269*|MARK2_ENST00000508192.1_Nonsense_Mutation_p.R302*|MARK2_ENST00000377809.4_Nonsense_Mutation_p.R302*|MARK2_ENST00000377810.3_Nonsense_Mutation_p.R269*|MARK2_ENST00000350490.7_Nonsense_Mutation_p.R302*|MARK2_ENST00000425897.2_Nonsense_Mutation_p.R269*|MARK2_ENST00000413835.2_Nonsense_Mutation_p.R302*|MARK2_ENST00000509502.2_Nonsense_Mutation_p.R269*|MARK2_ENST00000361128.5_Nonsense_Mutation_p.R302*|MARK2_ENST00000502399.3_Nonsense_Mutation_p.R302*|MARK2_ENST00000513765.2_Nonsense_Mutation_p.R269*	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	302	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CATGAAAGATCGATGGATGAA	0.562000													24	275					0	0	1	0	0
DNM1P34	729809	broad.mit.edu	37	15	75595057	75595057	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75595057C>T	ENST00000567292.1	-	0	249																											CTCCAGGCATCCCCAGGATCT	0.607000													3	8					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107416969	107416969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107416969C>T	ENST00000340010.5	-	15	1789	c.1605G>A	c.(1603-1605)gtG>gtA	p.V535V	SLC26A3_ENST00000422236.2_Silent_p.V500V	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	535	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TGAAAATTTTCACTCCTTCTG	0.358000													23	91					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76464763	76464763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76464763C>T	ENST00000389840.5	-	55	8796	c.8672G>A	c.(8671-8673)gGc>gAc	p.G2891D	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.G2900D					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTCATTCATGCCAAGGGACTT	0.552000													12	37					0	0	1	0	0
ACTR2	10097	broad.mit.edu	37	2	65482733	65482733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:65482733C>T	ENST00000260641.5	+	6	797	c.640C>T	c.(640-642)Cgc>Tgc	p.R214C	ACTR2_ENST00000377982.4_Missense_Mutation_p.R219C|ACTR2_ENST00000542850.1_Missense_Mutation_p.R159C	NM_005722.3	NP_005713.1	P61160	ARP2_HUMAN	ARP2 actin-related protein 2 homolog (yeast)	214					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)	12						TGAAACGGTTCGCATGATTAA	0.373000													46	102					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458358	45458358	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45458358G>A	ENST00000548424.1	+	0	448																											CTGCTGTTCAGGGTGGGGTCA	0.517000													11	24					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7439304	7439304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7439304C>T	ENST00000318881.6	+	5	1519	c.1282C>T	c.(1282-1284)Cct>Tct	p.P428S		NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	428	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CTTTGATGTCCCTCCCGAGAA	0.478000													17	77					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20432301	20432301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:20432301G>A	ENST00000377252.3	+	5	1460	c.619G>A	c.(619-621)Gat>Aat	p.D207N	PLXDC2_ENST00000377238.2_3'UTR|PLXDC2_ENST00000377242.3_Missense_Mutation_p.D158N	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	207						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						GGCAAATTTCGATCCCAGTGT	0.353000													46	104					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41459131	41459131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41459131C>T	ENST00000400454.1	-	22	4411	c.3934G>A	c.(3934-3936)Gac>Aac	p.D1312N		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1312	Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGAGAAGGGTCCCCAACAGCC	0.463000													27	68					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200967555	200967555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200967555G>A	ENST00000332129.2	-	14	2350	c.2034C>T	c.(2032-2034)atC>atT	p.I678I	KIF21B_ENST00000360529.5_Silent_p.I678I|KIF21B_ENST00000461742.2_Silent_p.I678I|KIF21B_ENST00000422435.2_Silent_p.I678I	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	678					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GTGTGTCTCGGATCTTGTTCT	0.602000													35	116					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227216844	227216844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:227216844G>A	ENST00000366769.3	-	29	5132	c.3841C>T	c.(3841-3843)Cct>Tct	p.P1281S	CDC42BPA_ENST00000366766.2_Missense_Mutation_p.P1316S|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.P1281S|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.P1253S|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.P1261S|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.P1200S|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.P1294S	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1294	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				GCTGACATAGGAAAAAGTCGT	0.433000													12	53					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54823363	54823363	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54823363C>T	ENST00000301219.3	-	4	299	c.180G>A	c.(178-180)ggG>ggA	p.G60G	LILRA5_ENST00000346508.3_Silent_p.G48G|AC008984.2_ENST00000507363.1_RNA|LILRA5_ENST00000446712.3_Silent_p.G48G|LILRA5_ENST00000432233.3_Silent_p.G60G	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	60	Ig-like C2-type 1.				innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACAGAGTTCCCCCGGCTGA	0.612000													35	88					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47681866	47681866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47681866C>T	ENST00000283303.2	+	6	1143	c.885C>T	c.(883-885)ttC>ttT	p.F295F	GPR115_ENST00000371220.1_Silent_p.F352F|GPR115_ENST00000327753.3_Silent_p.F295F	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	295					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						GCATAGCTTTCCCAACCTTGG	0.468000													22	43					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14797324	14797324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:14797324C>T	ENST00000403951.2	-	3	522	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	DGKB_ENST00000444700.2_Missense_Mutation_p.E35K|DGKB_ENST00000402815.1_Missense_Mutation_p.E35K|DGKB_ENST00000406247.3_Missense_Mutation_p.E35K|DGKB_ENST00000399322.3_Missense_Mutation_p.E35K|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Missense_Mutation_p.E35K|DGKB_ENST00000407950.1_Missense_Mutation_p.E35K			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	35					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CCATGGAATTCTTCAAGAACA	0.328000													14	51					0	0	1	0	0
PSMB11	122706	broad.mit.edu	37	14	23511881	23511881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23511881C>T	ENST00000408907.2	+	1	506	c.447C>T	c.(445-447)gcC>gcT	p.A149A		NM_001099780.1	NP_001093250.1	A5LHX3	PSB11_HUMAN	proteasome (prosome, macropain) subunit, beta type, 11	149					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(1)|kidney(2)|lung(4)	7	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		TGGCCACTGCCCTCTGCGGCT	0.617000													33	56					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053934	133053934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133053934G>A	ENST00000262283.5	-	8	869	c.770C>T	c.(769-771)cCc>cTc	p.P257L	OC90_ENST00000443356.2_Missense_Mutation_p.P61L|OC90_ENST00000254627.3_Missense_Mutation_p.P61L|OC90_ENST00000603859.1_Missense_Mutation_p.P61L			Q02509	OC90_HUMAN	otoconin 90	61					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GGTGAAGTGGGGGCCCAGGCA	0.587000													9	17					0	0	1	0	0
NEDD1	121441	broad.mit.edu	37	12	97339584	97339584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:97339584C>T	ENST00000266742.4	+	14	2107	c.1768C>T	c.(1768-1770)Cgt>Tgt	p.R590C	NEDD1_ENST00000557644.1_Missense_Mutation_p.R597C|NEDD1_ENST00000457368.2_Missense_Mutation_p.R501C|NEDD1_ENST00000429527.2_Missense_Mutation_p.R590C|NEDD1_ENST00000411739.2_Missense_Mutation_p.R501C	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	590					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol		p.R590C(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						CATTCAAATTCGTTTTATTCA	0.373000													33	54					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155720128	155720128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155720128G>A	ENST00000510397.1	+	4	993	c.814G>A	c.(814-816)Gat>Aat	p.D272N	RBM46_ENST00000281722.3_Missense_Mutation_p.D272N|RBM46_ENST00000514866.1_Missense_Mutation_p.D272N	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	272	RRM 3.						nucleotide binding|RNA binding	p.D272Y(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				GAAACTTAGAGATTATGCTTT	0.353000													18	50					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52539740	52539740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52539740G>A	ENST00000261839.7	-	15	1957	c.1796C>T	c.(1795-1797)cCt>cTt	p.P599L	MYO5C_ENST00000443683.2_3'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	599	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		TGAACCAAAAGGAGAAGGAGG	0.438000													30	79					0	0	1	0	0
KHDC1	80759	broad.mit.edu	37	6	73951407	73951407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73951407C>T	ENST00000370384.3	-	5	1059	c.559G>A	c.(559-561)Gat>Aat	p.D187N	KHDC1_ENST00000257765.5_Missense_Mutation_p.D114N|RP11-257K9.8_ENST00000423730.3_Intron	NM_001251874.1	NP_001238803.1	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	187						integral to membrane	RNA binding			large_intestine(1)|lung(4)|skin(1)	6						ACCAGGTCATCGTTGGTCAGA	0.557000													9	64					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43157211	43157211	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:43157211G>A	ENST00000522175.2	+	0	697							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATGTATTTGGACAAACTGCT	0.308000													6	75					0	0	1	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46120880	46120880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46120880G>A	ENST00000355105.3	-	5	1532	c.172C>T	c.(172-174)Ccc>Tcc	p.P58S	GPBP1L1_ENST00000290795.3_Missense_Mutation_p.P58S	NM_021639.4	NP_067652.1	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	58					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding		GPBP1L1/MAST2_ENST00000361297(2)	breast(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|stomach(1)	21	Acute lymphoblastic leukemia(166;0.155)					GTTCGTAGGGGACCATTGTTA	0.463000													46	85					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879424	3879424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3879424G>A	ENST00000315677.3	-	4	1240	c.645C>T	c.(643-645)taC>taT	p.Y215Y	DLGAP1-AS3_ENST00000577649.1_RNA|DLGAP1_ENST00000581527.1_Silent_p.Y215Y|DLGAP1_ENST00000515196.2_Silent_p.Y215Y|DLGAP1_ENST00000584874.1_Silent_p.Y215Y	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	215					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				AGGGGGCGTGGTAGATGCACA	0.677000													52	140					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52830625	52830625	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52830625G>A	ENST00000449956.2	+	3	249	c.243G>A	c.(241-243)gtG>gtA	p.V81V	ITIH3_ENST00000416872.2_Silent_p.V81V	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	81	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CCTTTGATGTGGAGCTGCCCA	0.567000													8	21					0	0	1	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51629059	51629059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51629059C>T	ENST00000440804.3	+	2	694	c.627C>T	c.(625-627)acC>acT	p.T209T	SIGLEC9_ENST00000250360.3_Silent_p.T209T	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	209	Ig-like C2-type 1.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ACCATGGCACCAGCCTCACCT	0.652000													11	120					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501656	140501656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140501656C>T	ENST00000194152.1	+	1	76	c.76C>T	c.(76-78)Cgc>Tgc	p.R26C		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		26					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTCTCAGGTTCGCCTCGAGCC	0.502000													27	67					0	0	1	0	0
PMS1	5378	broad.mit.edu	37	2	190670557	190670557	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:190670557C>T	ENST00000409985.1	+	4	659	c.495C>T	c.(493-495)ctC>ctT	p.L165L	PMS1_ENST00000441310.2_Intron|PMS1_ENST00000418224.3_Intron|PMS1_ENST00000432292.3_Intron|PMS1_ENST00000421722.1_Intron|PMS1_ENST00000447232.2_Intron|PMS1_ENST00000374826.4_Intron|PMS1_ENST00000409823.3_Intron			P54277	PMS1_HUMAN	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			AAAAGTTACTCGGTGAATACA	0.323000			"""Mis, N"""			"""colorectal, endometrial, ovarian"""		Direct reversal of damage;Mismatch excision repair (MMR)					3	12					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38317409	38317409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38317409C>T	ENST00000311856.4	+	7	1108	c.1059C>T	c.(1057-1059)ctC>ctT	p.L353L	SLC22A13_ENST00000450935.2_3'UTR	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	353						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		GCCTGAGCCTCCAAGTGGGGG	0.572000													19	49					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71903228	71903228	+	Missense_Mutation	SNP	G	G	A	rs145380453		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71903228G>A	ENST00000393679.1	+	2	447	c.11G>A	c.(10-12)cGg>cAg	p.R4Q	FOLR1_ENST00000393676.3_Missense_Mutation_p.R4Q|FOLR1_ENST00000312293.4_Missense_Mutation_p.R4Q|RP11-807H22.7_ENST00000378140.3_RNA|FOLR1_ENST00000393681.2_Missense_Mutation_p.R4Q			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	4					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						ATGGCTCAGCGGATGACAACA	0.577000													25	69					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130507048	130507048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130507048C>T	ENST00000314830.8	-	7	1708	c.1595G>A	c.(1594-1596)gGg>gAg	p.G532E	SH2D3C_ENST00000420366.1_Missense_Mutation_p.G374E|SH2D3C_ENST00000373274.3_Missense_Mutation_p.G372E|SH2D3C_ENST00000373276.3_Missense_Mutation_p.G464E|SH2D3C_ENST00000471939.1_5'UTR|SH2D3C_ENST00000373277.4_Missense_Mutation_p.G375E|SH2D3C_ENST00000429553.1_Missense_Mutation_p.G178E	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	532					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTCAGGGGCCCCATTTTCTGA	0.612000													34	255					0	0	1	0	0
SSTR5	6755	broad.mit.edu	37	16	1129702	1129702	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1129702G>A	ENST00000293897.4	+	1	922	c.834G>A	c.(832-834)caG>caA	p.Q278Q	SSTR5_ENST00000562758.1_Intron|SSTR5_ENST00000397547.2_Silent_p.Q278Q	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	278					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CGCTGCCCCAGGAGCCCGCCT	0.622000													15	63					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46145989	46145989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:46145989C>T	ENST00000256413.3	+	2	348	c.53C>T	c.(52-54)tCc>tTc	p.S18F	CTIF_ENST00000382998.4_Missense_Mutation_p.S18F	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	18	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						AGCAGCCGCTCCCAGGAGATC	0.642000													4	6					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26781309	26781309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26781309G>A	ENST00000376236.4	+	3	509	c.54G>A	c.(52-54)gaG>gaA	p.E18E	APBB1IP_ENST00000356785.4_Silent_p.E18E	NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	18					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TGCTGGGAGAGATGGATCTTC	0.388000													39	96					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54142212	54142212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:54142212C>T	ENST00000265572.3	-	4	1085	c.788G>A	c.(787-789)cGa>cAa	p.R263Q	RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000524278.1_Missense_Mutation_p.R174Q|OPRK1_ENST00000520287.1_Missense_Mutation_p.R263Q	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	263					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	ATCTTTCTCTCGGGAGCCAGA	0.547000													25	51					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50752301	50752301	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50752301C>T	ENST00000440075.2	+	13	1434	c.1387C>T	c.(1387-1389)Ctg>Ttg	p.L463L	MYH14_ENST00000425460.1_Silent_p.L463L|MYH14_ENST00000262269.8_Silent_p.L463L|MYH14_ENST00000376970.2_Silent_p.L455L|MYH14_ENST00000598205.1_Silent_p.L463L|MYH14_ENST00000596571.1_Silent_p.L455L|MYH14_ENST00000601313.1_Silent_p.L463L			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	455	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CTTCCGCTGGCTGGTTCTGCG	0.667000													6	18					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88945680	88945680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:88945680C>T	ENST00000268679.4	-	11	2056	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K	CBFA2T3_ENST00000360302.2_Missense_Mutation_p.E468K|CBFA2T3_ENST00000448839.1_Missense_Mutation_p.E478K|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.E468K|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.E516K	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	554					cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E554K(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GGCCCTACCTCGCTGGAGTCC	0.697000			T	RUNX1	AML								16	41					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113679831	113679831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113679831C>T	ENST00000003302.4	-	17	2186	c.2118G>A	c.(2116-2118)atG>atA	p.M706I	USP28_ENST00000545540.1_Missense_Mutation_p.M581I|USP28_ENST00000544967.1_Missense_Mutation_p.M414I|USP28_ENST00000260188.5_Missense_Mutation_p.M706I	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	706					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TGGAGGACTCCATTTGAGGGA	0.463000													92	223					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72346770	72346770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:72346770C>T	ENST00000299687.5	+	1	3795	c.3795C>T	c.(3793-3795)ctC>ctT	p.L1265L	ZNF407_ENST00000309902.6_Silent_p.L1265L|ZNF407_ENST00000582337.1_Silent_p.L1265L|ZNF407_ENST00000577538.1_Silent_p.L1265L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GCCCTGTGCTCGTTGTGACAA	0.567000													10	29					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53683068	53683068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53683068C>T	ENST00000257934.4	+	21	4994	c.4903C>T	c.(4903-4905)Cac>Tac	p.H1635Y	ESPL1_ENST00000552462.1_Missense_Mutation_p.H1635Y	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1635					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						GCTGCTCACCCACCTCCACAG	0.602000													10	152					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73544822	73544822	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73544822G>A	ENST00000224721.6	+	42	5697	c.5692G>A	c.(5692-5694)Ggc>Agc	p.G1898S		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1893	Cadherin 18.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CATCACTGCGGGCAACCGCGA	0.597000													25	47					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6939829	6939829	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:6939829G>A	ENST00000383032.1	+	12	1499	c.852G>A	c.(850-852)tgG>tgA	p.W284*	TBL1Y_ENST00000346432.3_Nonsense_Mutation_p.W284*|TBL1Y_ENST00000355162.2_Nonsense_Mutation_p.W284*	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	284					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						CTCTGAAATGGAACAAAAAGG	0.383000													6	14					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43385610	43385610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43385610G>A	ENST00000372851.3	-	5	586	c.520C>T	c.(520-522)Cgc>Tgc	p.R174C	RIMS4_ENST00000541604.2_Missense_Mutation_p.R175C	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	174	C2.				exocytosis|neurotransmitter transport	cell junction|synapse		p.R174C(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				AGCGACTTGCGAGCGACTTTG	0.567000													122	282					0	0	1	0	0
KRTAP12-1	353332	broad.mit.edu	37	21	46101961	46101961	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46101961G>A	ENST00000391617.1	-	1	117	c.78C>T	c.(76-78)atC>atT	p.I26I	TSPEAR_ENST00000323084.4_Intron	NM_181686.1	NP_859014.1	P59990	KR121_HUMAN	keratin associated protein 12-1	26	14 X 5 AA approximate repeats.					keratin filament				kidney(1)|large_intestine(1)|lung(1)|skin(2)	5						AGCCCACGGGGATGTAACAGG	0.667000													8	95					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43773519	43773519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43773519G>A	ENST00000372476.3	+	7	1045	c.966G>A	c.(964-966)caG>caA	p.Q322Q	TIE1_ENST00000433781.2_Intron|TIE1_ENST00000538015.1_Silent_p.Q322Q|TIE1_ENST00000441333.2_Intron	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	322	EGF-like 3.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCAGTGTCAGAATGGTGGCA	0.547000													21	57					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039417	31039417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:31039417C>T	ENST00000355537.3	+	4	3038	c.2891C>T	c.(2890-2892)tCc>tTc	p.S964F		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	964					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGCAAGTCCTCCCAGAGGAAG	0.582000													31	161					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29432720	29432720	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29432720G>A	ENST00000389048.3	-	25	4674	c.3768C>T	c.(3766-3768)ctC>ctT	p.L1256L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1256	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GACAGGTCAAGAGGCAGTTTC	0.507000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				16	44					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043470	20043470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20043470G>A	ENST00000570682.1	-	2	949	c.649C>T	c.(649-651)Cgt>Tgt	p.R217C		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	217						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						CCACGGAGACGAAAATTGCTC	0.507000													21	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179497989	179497989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179497989G>A	ENST00000589042.1	-	233	43235	c.43011C>T	c.(43009-43011)caC>caT	p.H14337H	TTN_ENST00000342992.6_Silent_p.H11769H|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.H12696H|TTN_ENST00000342175.6_Silent_p.H5464H|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.H5397H|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.H5272H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12696							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATTTCAAAGTGGGCTGTTT	0.413000													49	79					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107868959	107868959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107868959C>T	ENST00000328300.6	+	35	3285	c.3041C>T	c.(3040-3042)cCt>cTt	p.P1014L	COL4A5_ENST00000361603.2_Missense_Mutation_p.P1014L	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1014	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CCTGGTCTCCCTGGACAGCCA	0.433000									Alport syndrome with Diffuse Leiomyomatosis				6	18					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85436463	85436463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:85436463G>A	ENST00000359152.5	-	1	2608	c.2609C>T	c.(2608-2610)tCc>tTc	p.S870F	SYTL2_ENST00000524452.1_Intron|SYTL2_ENST00000354566.3_Missense_Mutation_p.S346F|SYTL2_ENST00000316356.4_Intron|SYTL2_ENST00000528231.1_Intron|SYTL2_ENST00000527523.1_Intron|SYTL2_ENST00000389960.4_Intron|SYTL2_ENST00000525423.1_Missense_Mutation_p.S346F	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	0	C2 2.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		GGAAAGCTGGGAAGTTGGATC	0.498000													37	86					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803597	185803597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185803597G>A	ENST00000302277.6	+	4	4068	c.3474G>A	c.(3472-3474)ggG>ggA	p.G1158G		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1158						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTTGTCCTGGGAACCAGCCAA	0.507000													61	132					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31294508	31294508	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:31294508G>A	ENST00000542188.1	-	27	4759	c.4446C>T	c.(4444-4446)tcC>tcT	p.S1482S	TRPM1_ENST00000397795.2_Silent_p.S1443S|RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000256552.6_Silent_p.S1465S	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1443					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTCTTCCCCGGGAATAGACGA	0.453000													46	86					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82880378	82880378	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:82880378C>T	ENST00000298281.4	+	8	3453	c.3001C>T	c.(3001-3003)Caa>Taa	p.Q1001*		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	1001	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						CCCTTTAGTCCAACAAGGAGG	0.507000													16	42					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37441019	37441019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37441019G>A	ENST00000374660.1	+	12	1608	c.1509G>A	c.(1507-1509)aaG>aaA	p.K503K	ANKRD30A_ENST00000361713.1_Silent_p.K503K|ANKRD30A_ENST00000602533.1_Silent_p.K503K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	559						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.K503N(1)		NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CCAAACAAAAGGACTATGAAG	0.294000													23	89					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54395001	54395001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54395001C>T	ENST00000263431.3	+	6	885	c.603C>T	c.(601-603)atC>atT	p.I201I	PRKCG_ENST00000540413.1_Silent_p.I201I|PRKCG_ENST00000536044.1_Silent_p.I201I|PRKCG_ENST00000542049.1_Silent_p.I88I	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	201	C2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TGAAGCTCATCCCAGACCCTC	0.527000													41	118					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839493	27839493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27839493G>A	ENST00000356790.2	+	3	315	c.70G>A	c.(70-72)Gat>Aat	p.D24N		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	24										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AGGGCTGGAAGATTTGATAGA	0.512000													15	23					0	0	1	0	0
SOCS2	8835	broad.mit.edu	37	12	93968856	93968856	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:93968856C>T	ENST00000340600.2	+	3	1096	c.498C>T	c.(496-498)ctC>ctT	p.L166L	SOCS2_ENST00000549122.1_Silent_p.L166L|SOCS2_ENST00000548537.1_3'UTR|SOCS2_ENST00000549206.1_Silent_p.L166L|SOCS2_ENST00000536696.2_Silent_p.L166L|SOCS2_ENST00000551556.1_Silent_p.L166L	NM_001270468.1|NM_001270469.1|NM_001270471.1|NM_003877.4	NP_001257397.1|NP_001257398.1|NP_001257400.1|NP_003868.1	O14508	SOCS2_HUMAN	suppressor of cytokine signaling 2	166	SOCS box.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)	14						TGCAGCATCTCTGTAGGCTCA	0.478000													28	47					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38983185	38983185	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38983185C>T	ENST00000355481.4	+	38	6314	c.6183C>T	c.(6181-6183)agC>agT	p.S2061S	RYR1_ENST00000359596.3_Silent_p.S2061S|RYR1_ENST00000360985.3_Silent_p.S2061S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2061	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCTGGGCAGCCGCCTCATGA	0.542000													9	81					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26849116	26849116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26849116G>A	ENST00000376236.4	+	12	1693	c.1238G>A	c.(1237-1239)gGa>gAa	p.G413E		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	413	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium		p.G413A(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TGGGTCATGGGAATACGGATA	0.498000													20	93					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99551337	99551337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:99551337G>A	ENST00000373034.4	-	6	5060	c.3385C>T	c.(3385-3387)Ctg>Ttg	p.L1129L	PCDH19_ENST00000420881.2_Silent_p.L1081L|PCDH19_ENST00000255531.7_Silent_p.L1082L	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	1129					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CCTTCCTTCAGAATGGGGCTG	0.512000													60	50					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113533736	113533736	+	Missense_Mutation	SNP	G	G	A	rs140847408		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113533736G>A	ENST00000505019.1	-	7	2736	c.2611C>T	c.(2611-2613)Cca>Tca	p.P871S	C4orf21_ENST00000309071.5_Missense_Mutation_p.P871S|C4orf21_ENST00000445203.2_Missense_Mutation_p.P840S	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	871										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GTAATAAATGGTTTCCTCACT	0.284000													8	55					0	0	1	0	0
IFNA7	3444	broad.mit.edu	37	9	21201647	21201647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21201647C>T	ENST00000239347.3	-	1	557	c.518G>A	c.(517-519)aGa>aAa	p.R173K		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	173					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGAGAAGGATCTCATGATTTC	0.388000													153	244					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131375669	131375669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131375669C>T	ENST00000372739.3	+	40	5163	c.5053C>T	c.(5053-5055)Ctg>Ttg	p.L1685L	SPTAN1_ENST00000372731.4_Silent_p.L1680L|SPTAN1_ENST00000358161.5_Silent_p.L1685L	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1680					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GGTGGAGGCCCTGCTGGCATC	0.478000													15	57					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1808290	1808290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1808290C>T	ENST00000518288.1	+	5	656	c.493C>T	c.(493-495)Ctc>Ttc	p.L165F	ARHGEF10_ENST00000520359.1_Missense_Mutation_p.L141F|ARHGEF10_ENST00000398560.1_Missense_Mutation_p.L165F|ARHGEF10_ENST00000262112.6_Missense_Mutation_p.L165F|ARHGEF10_ENST00000398564.1_Missense_Mutation_p.L165F|ARHGEF10_ENST00000349830.3_Missense_Mutation_p.L141F			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	165					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CAACCTGCCCCTCCTGCTGCC	0.662000													27	51					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15890615	15890615	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15890615G>A	ENST00000587443.2	-	0	182					NR_033864.1																						ATAGGTCCAGGCCAGGAAGCC	0.627000													13	46					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116241795	116241795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116241795C>T	ENST00000374140.2	+	5	649	c.440C>T	c.(439-441)gCc>gTc	p.A147V	RGS3_ENST00000350696.5_Missense_Mutation_p.A147V|RGS3_ENST00000317613.6_Missense_Mutation_p.A35V	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	147	C2.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						TCCATTGATGCCCAGGACCGG	0.577000													43	129					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120387522	120387522	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120387522C>T	ENST00000602047.1	+	18	1976	c.864C>T	c.(862-864)ttC>ttT	p.F288F	PCDP1_ENST00000413369.3_Silent_p.F574F			Q4G0U5	PCDP1_HUMAN		574						cilium	calmodulin binding					Colorectal(110;0.196)					ATTCCTTCTTCAATCTGCAGG	0.333000													25	47					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1032042	1032042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1032042C>T	ENST00000421673.2	-	3	177	c.127G>A	c.(127-129)Ggc>Agc	p.G43S		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	43					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAGCACTGGCCTTTGTCCGGG	0.637000													9	28					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96053752	96053752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:96053752C>T	ENST00000358812.4	+	5	994	c.860C>T	c.(859-861)tCt>tTt	p.S287F	MANEA_ENST00000474553.1_3'UTR	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	287	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		ACCTCAGGGTCTCGGAGTATT	0.383000													25	43					0	0	1	0	0
EFNA4	1945	broad.mit.edu	37	1	155041536	155041536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155041536C>T	ENST00000427683.2	+	4	574	c.511C>T	c.(511-513)Cct>Tct	p.P171S	EFNA3_ENST00000556931.1_Intron|EFNA3_ENST00000505139.1_Intron|EFNA4_ENST00000368409.3_3'UTR|EFNA4_ENST00000359751.4_Silent_p.S177S					ephrin-A4											breast(1)|endometrium(1)|large_intestine(1)|ovary(1)	4	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			AGGAGGGATCCCTGCTGCCTG	0.577000													6	112					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54395847	54395847	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54395847G>A	ENST00000263431.3	+	7	1053	c.771G>A	c.(769-771)ggG>ggA	p.G257G	PRKCG_ENST00000540413.1_Silent_p.G257G|PRKCG_ENST00000536044.1_Silent_p.G257G|PRKCG_ENST00000542049.1_Silent_p.G144G	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	257	C2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACTTCATGGGGGCCATGTCCT	0.657000													6	23					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17435792	17435792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17435792G>A	ENST00000159087.4	-	17	3223	c.3065C>T	c.(3064-3066)cCt>cTt	p.P1022L		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	1022						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						GAGGAAGGCAGGCAGGCGGGT	0.672000													59	140					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123145750	123145750	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123145750C>T	ENST00000264501.4	+	23	3084	c.2711C>T	c.(2710-2712)cCt>cTt	p.P904L	KIAA1109_ENST00000388738.3_Missense_Mutation_p.P904L|KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000455637.1_Missense_Mutation_p.P904L			Q2LD37	K1109_HUMAN	KIAA1109	904					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GAAGGTCTTCCTTTGGGAAGC	0.493000													20	48					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15829321	15829321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15829321C>T	ENST00000338282.6	-	26	3514	c.3408G>A	c.(3406-3408)aaG>aaA	p.K1136K	MYH11_ENST00000576790.1_Silent_p.K1136K|MYH11_ENST00000396324.3_Silent_p.K1143K|MYH11_ENST00000452625.2_Silent_p.K1143K|MYH11_ENST00000300036.5_Silent_p.K1136K	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1136					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GCTTTTCAGCCTTGTTCCTGG	0.597000			T	CBFB	AML								47	94					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70260710	70260710	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70260710C>T	ENST00000301843.8	+	6	560	c.354C>T	c.(352-354)gtC>gtT	p.V118V	CTTN_ENST00000376561.3_Silent_p.V118V|CTTN_ENST00000346329.3_Silent_p.V118V	NM_005231.3	NP_005222.2	Q14247	SRC8_HUMAN	cortactin	118						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		TGGACTCGGTCCGTGGCTTCG	0.562000													22	103					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110477422	110477422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110477422C>T	ENST00000378402.5	+	49	8465	c.8361C>T	c.(8359-8361)ggC>ggT	p.G2787G		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2787					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACAAGGCTGGCTTTCGCTGGG	0.398000										HNSCC(38;0.096)			29	52					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1996215	1996215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1996215C>T	ENST00000382722.5	-	7	1164	c.802G>A	c.(802-804)Gag>Aag	p.E268K	CACNA2D4_ENST00000585708.1_Missense_Mutation_p.E204K|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.E268K|CACNA2D4_ENST00000586184.1_Missense_Mutation_p.E268K|CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.E204K	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	268						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		ACTCCATTCTCATCAGGTGTC	0.502000													4	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179395723	179395723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179395723C>T	ENST00000589042.1	-	358	105843	c.105619G>A	c.(105619-105621)Gaa>Aaa	p.E35207K	TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000589355.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E32639K|TTN-AS1_ENST00000587944.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E33566K|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E26334K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E26267K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E26142K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	33566							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTTCCCTTCACTGTTTTCT	0.488000													131	291					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20618815	20618815	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20618815G>A	ENST00000504154.1	+	35	4382	c.4130G>A	c.(4129-4131)gGa>gAa	p.G1377E	SLIT2_ENST00000273739.5_Missense_Mutation_p.G1390E|SLIT2_ENST00000503823.1_Missense_Mutation_p.G1369E|SLIT2_ENST00000503837.1_Missense_Mutation_p.G1373E	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1377					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CCTTGCCTTGGAAATAAGTAA	0.567000													9	59					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383180	22383180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22383180C>T	ENST00000328795.4	+	1	799	c.708C>T	c.(706-708)gcC>gcT	p.A236A	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		AGAACAAGGCCATGTCCACGT	0.502000													33	93					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37120378	37120378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:37120378G>A	ENST00000274258.7	-	49	9369	c.5782C>T	c.(5782-5784)Ccg>Tcg	p.P1928S	C5orf42_ENST00000508244.1_Missense_Mutation_p.P3030S|C5orf42_ENST00000512288.1_5'UTR|C5orf42_ENST00000425232.2_Missense_Mutation_p.P3030S			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	3030										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ATATAACTCGGTTTGGACATA	0.358000													34	58					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212777	62212777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:62212777G>A	ENST00000519846.1	+	3	863	c.391G>A	c.(391-393)Gaa>Aaa	p.E131K	CLVS1_ENST00000325897.4_Missense_Mutation_p.E131K|RP11-787D18.1_ENST00000518064.1_RNA|CLVS1_ENST00000518592.1_Intron			Q8IUQ0	CLVS1_HUMAN	clavesin 1	131	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CGGGGTGCTGGAAAACCGAGA	0.463000													19	36					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969584	47969584	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47969584G>A	ENST00000236877.6	-	2	472	c.77C>T	c.(76-78)cCc>cTc	p.P26L	SLC8A2_ENST00000539381.1_Intron|SLC8A2_ENST00000542837.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	26					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CGGCAGGGAGGGGGTTGGGGT	0.736000													4	4					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104032266	104032266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104032266G>A	ENST00000374874.3	+	3	607	c.168G>A	c.(166-168)atG>atA	p.M56I	LPPR1_ENST00000395056.2_Missense_Mutation_p.M56I	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		56						integral to membrane	catalytic activity										GAGACTTAATGAAGCCTTACC	0.488000													12	43					0	0	1	0	0
MAP2K6	5608	broad.mit.edu	37	17	67513729	67513729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67513729C>T	ENST00000590474.1	+	4	508	c.221C>T	c.(220-222)cCc>cTc	p.P74L	MAP2K6_ENST00000589647.1_Missense_Mutation_p.P18L	NM_002758.3	NP_002749.2	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	74	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	20	Breast(10;6.05e-10)					CGGCACGTGCCCAGCGGGCAG	0.507000													14	33					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94913333	94913333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94913333C>T	ENST00000289495.5	+	15	3396	c.3180C>T	c.(3178-3180)atC>atT	p.I1060I	PPP1R9A_ENST00000424654.1_Silent_p.I1078I|PPP1R9A_ENST00000433360.1_Silent_p.I1100I|PPP1R9A_ENST00000340694.4_Intron|PPP1R9A_ENST00000456331.2_Silent_p.I1078I|PPP1R9A_ENST00000433881.1_Intron	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	844	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAACAGGATCTTCAGAGGCA	0.438000										HNSCC(28;0.073)			21	30					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95107644	95107644	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95107644G>A	ENST00000469935.1	+	0	249					NR_015340.1																						TCAGACCAAGGACCCCAGAGG	0.542000													7	20					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1213673	1213673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1213673C>T	ENST00000304460.10	+	5	815	c.759C>T	c.(757-759)ttC>ttT	p.F253F		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	253					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.F253L(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCATCGTCTTCCTCTTCACGC	0.652000													15	21					0	0	1	0	0
ZNF100	163227	broad.mit.edu	37	19	21909553	21909553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21909553C>T	ENST00000358296.6	-	5	1759	c.1561G>A	c.(1561-1563)Gac>Aac	p.D521N	ZNF100_ENST00000305570.6_Missense_Mutation_p.D457N	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						TGGTTAAAGTCTTTACCACAT	0.373000													17	98					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100123421	100123421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100123421C>T	ENST00000330710.5	+	3	1085	c.987C>T	c.(985-987)ttC>ttT	p.F329F	HHIPL1_ENST00000357223.2_Silent_p.F329F	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	329					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				TCTACATCTTCACTGGAGATG	0.507000													147	357					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70982076	70982076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70982076C>T	ENST00000276594.2	-	2	221	c.20G>A	c.(19-21)aGt>aAt	p.S7N		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CACGGCCTCACTTGGCCGGGG	0.687000													3	8					0	0	1	0	0
SDR9C7	121214	broad.mit.edu	37	12	57324024	57324024	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57324024G>A	ENST00000293502.1	-	2	689	c.546C>T	c.(544-546)ttC>ttT	p.F182F		NM_148897.2	NP_683695.1	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C, member 7	182						cytoplasm	binding|oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|pancreas(1)	7						TGCTGTCAGAGAAGGCCTCAA	0.552000													37	101					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15276853	15276853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15276853C>T	ENST00000263388.2	-	30	5487	c.5412G>A	c.(5410-5412)gaG>gaA	p.E1804E		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1804					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TTGGCATTGGCTCCAGAGCCC	0.577000													22	48					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48372493	48372493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48372493G>A	ENST00000380518.3	-	42	2946	c.2782C>T	c.(2782-2784)Ccc>Tcc	p.P928S	COL2A1_ENST00000337299.6_Missense_Mutation_p.P859S|COL2A1_ENST00000493991.1_5'UTR	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	928	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GCACCTTTGGGACCATCTTTT	0.627000													12	40					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103900460	103900460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103900460C>T	ENST00000278070.2	+	5	2234	c.2195C>T	c.(2194-2196)tCt>tTt	p.S732F	PPRC1_ENST00000413464.2_Missense_Mutation_p.S732F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	732					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTTGTGGATTCTCTGAAAATT	0.547000													48	105					0	0	1	0	0
PCYT1B	9468	broad.mit.edu	37	X	24608226	24608226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:24608226C>T	ENST00000379145.1	-	4	390	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	PCYT1B_ENST00000356768.4_Missense_Mutation_p.E134K|PCYT1B_ENST00000379144.2_Missense_Mutation_p.E134K|PCYT1B_ENST00000492876.1_5'UTR	NM_001163264.1	NP_001156736.1	Q9Y5K3	PCY1B_HUMAN	phosphate cytidylyltransferase 1, choline, beta	134	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity			breast(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	17					Choline(DB00122)	CTGAGAGCTTCGTATCTCTCG	0.443000													23	14					0	0	1	0	0
PHF13	148479	broad.mit.edu	37	1	6681627	6681627	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6681627G>A	ENST00000377648.4	+	4	1215	c.833G>A	c.(832-834)cGg>cAg	p.R278Q	PHF13_ENST00000495385.1_Intron	NM_153812.2	NP_722519.2	Q86YI8	PHF13_HUMAN	PHD finger protein 13	278					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(3)	7	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		CAAAAGTGCCGGGACTCCAAG	0.577000													19	61					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756742	56756742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56756742G>A	ENST00000326855.2	+	1	396	c.354G>A	c.(352-354)atG>atA	p.M118I		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						TGGCTATGATGGCAGTGGATC	0.418000													50	82					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033749	82033749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82033749C>T	ENST00000328945.5	-	3	276	c.149G>A	c.(148-150)gGa>gAa	p.G50E	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	50					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						AAACTTGATTCCTTCTGGAAT	0.463000													39	138					0	0	1	0	0
CPLX3	594855	broad.mit.edu	37	15	75122545	75122545	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75122545C>T	ENST00000395018.4	+	3	484	c.327C>T	c.(325-327)atC>atT	p.I109I	RP11-414J4.2_ENST00000564823.1_RNA	NM_001030005.2	NP_001025176.1	Q8WVH0	CPLX3_HUMAN	complexin 3	109						cell junction|synapse	syntaxin binding			large_intestine(2)|lung(2)	4						CCAAGATGATCGAGGAGGACA	0.617000													17	97					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	146997584	146997584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:146997584C>T	ENST00000265272.5	-	19	2703	c.2236G>A	c.(2236-2238)Gag>Aag	p.E746K	JAKMIP2_ENST00000507386.1_Missense_Mutation_p.E725K|JAKMIP2_ENST00000333010.6_Missense_Mutation_p.E704K	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	746						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCTCAGCTCCTCTTGCTGT	0.433000													24	83					0	0	1	0	0
TLK1	9874	broad.mit.edu	37	2	171871371	171871371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171871371C>T	ENST00000442919.2	-	13	1795	c.1180G>A	c.(1180-1182)Gat>Aat	p.D394N	TLK1_ENST00000434911.2_Missense_Mutation_p.D346N|TLK1_ENST00000360843.3_Missense_Mutation_p.D463N|TLK1_ENST00000521943.1_Missense_Mutation_p.D394N|TLK1_ENST00000431350.2_Missense_Mutation_p.D442N	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1	442					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TGTGAATTATCTTCATTGTTT	0.368000													29	89					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537744	55537744	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55537744C>T	ENST00000220676.1	+	4	1450	c.1302C>T	c.(1300-1302)atC>atT	p.I434I		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	434					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACACAGATATCATCCAGGGAA	0.448000													32	78					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594181	179594181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179594181C>T	ENST00000589042.1	-	64	18926	c.18702G>A	c.(18700-18702)aaG>aaA	p.K6234K	TTN_ENST00000342992.6_Silent_p.K4990K|TTN_ENST00000591111.1_Silent_p.K5917K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5917	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTGTTATTCTTCAGCCAAG	0.453000													50	85					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74700994	74700994	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74700994G>A	ENST00000373032.3	-	3	491	c.399C>T	c.(397-399)ttC>ttT	p.F133F		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	133					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					GACACCATCGGAATTTTGCAT	0.502000													41	158					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50794294	50794294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50794294C>T	ENST00000440075.2	+	36	5163	c.5116C>T	c.(5116-5118)Cgc>Tgc	p.R1706C	MYH14_ENST00000425460.1_Missense_Mutation_p.R1673C|MYH14_ENST00000262269.8_Missense_Mutation_p.R1706C|MYH14_ENST00000376970.2_Missense_Mutation_p.R1698C|MYH14_ENST00000598205.1_Missense_Mutation_p.R1673C|MYH14_ENST00000596571.1_Missense_Mutation_p.R1665C|MYH14_ENST00000601313.1_Missense_Mutation_p.R1706C			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1665					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GAAGCAGCTTCGCAAGATGCA	0.642000													11	13					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55047106	55047106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55047106C>T	ENST00000335056.3	+	4	689	c.651C>T	c.(649-651)atC>atT	p.I217I	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		ACATTGTGATCACAGGTGAGT	0.527000													28	103					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93982115	93982115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:93982115C>T	ENST00000369303.4	-	6	1534	c.1350G>A	c.(1348-1350)atG>atA	p.M450I		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	450	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTCTCTCCTTCATTACTCCAC	0.438000													57	56					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26692881	26692881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26692881G>A	ENST00000529632.2	+	4	1193	c.997G>A	c.(997-999)Gaa>Aaa	p.E333K	SEZ6L_ENST00000360929.3_Missense_Mutation_p.E333K|SEZ6L_ENST00000402979.1_Missense_Mutation_p.E106K|SEZ6L_ENST00000404234.3_Missense_Mutation_p.E333K|SEZ6L_ENST00000343706.4_Missense_Mutation_p.E333K|SEZ6L_ENST00000403121.1_Missense_Mutation_p.E106K|SEZ6L_ENST00000248933.6_Missense_Mutation_p.E333K	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	333	CUB 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GTCCGATGGGGAACTGCTCTC	0.582000													11	24					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1653404	1653404	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1653404G>A	ENST00000252804.4	-	17	2198	c.2148C>T	c.(2146-2148)ctC>ctT	p.L716L		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	716					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGTTTGCGATGAGGTTCAGGT	0.582000													10	86					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	424297	424297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:424297G>A	ENST00000256509.2	+	18	2761	c.2119G>A	c.(2119-2121)Gaa>Aaa	p.E707K	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Missense_Mutation_p.E691K	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	691					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGCCGTGAACGAAGTAGGGAG	0.463000													28	45					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537337	5537337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5537337G>A	ENST00000380184.1	-	1	598	c.335C>T	c.(334-336)tCc>tTc	p.S112F	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	112										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GTCCCGGAAGGAATGGGCTAG	0.537000													19	70					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457509	110457509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110457509C>T	ENST00000378402.5	+	38	5515	c.5411C>T	c.(5410-5412)cCt>cTt	p.P1804L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1804	IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTTGTGACTCCTCTCCCAGTT	0.463000										HNSCC(38;0.096)			31	81					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179414324	179414324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179414324C>T	ENST00000589042.1	-	338	92349	c.92125G>A	c.(92125-92127)Gat>Aat	p.D30709N	RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D28141N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D29068N|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D21836N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D21769N|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D21644N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29068	Ig-like 138.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCACTGGATCAGAATCAAGT	0.373000													25	99					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113303252	113303252	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113303252G>A	ENST00000389385.4	+	6	761	c.264G>A	c.(262-264)aaG>aaA	p.K88K	RPH3A_ENST00000420983.2_Silent_p.K88K|RPH3A_ENST00000415485.3_Silent_p.K88K|RPH3A_ENST00000551052.1_Silent_p.K84K|RPH3A_ENST00000543106.2_Silent_p.K88K|RPH3A_ENST00000447659.2_Silent_p.K39K|RPH3A_ENST00000548866.1_Silent_p.K39K	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	88	RabBD.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ACATGAGGAAGAACGTGGCTG	0.537000													7	107					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105417287	105417287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105417287G>A	ENST00000333244.5	-	7	4620	c.4501C>T	c.(4501-4503)Ccg>Tcg	p.P1501S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1501						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCGAACGACGGCATCTTGAAC	0.602000													45	289					0	0	1	0	0
IL34	146433	broad.mit.edu	37	16	70693520	70693520	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70693520G>A	ENST00000429149.2	+	6	957		c.e6-1		IL34_ENST00000566361.1_Splice_Site|IL34_ENST00000288098.2_Splice_Site	NM_001172771.1|NM_152456.2	NP_001166242.1|NP_689669.2	Q6ZMJ4	IL34_HUMAN	interleukin 34						positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			breast(1)|central_nervous_system(1)|kidney(9)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(2)	17						CTCCTTTCCAGGATGTGGAGG	0.627000													8	26					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76521136	76521136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76521136G>A	ENST00000389840.5	-	25	3931	c.3807C>T	c.(3805-3807)caC>caT	p.H1269H	DNAH17_ENST00000585328.1_Silent_p.H1270H					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGACCTCCCGGTGGCAGGCCT	0.657000													14	55					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67406248	67406248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:67406248G>A	ENST00000382713.5	+	6	837	c.647G>A	c.(646-648)gGa>gAa	p.G216E	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	216	IRS-type PTB.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				ACAAGGGAAGGAGAAATGATC	0.443000													45	123					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50056163	50056163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50056163C>T	ENST00000281631.5	+	5	470	c.312C>T	c.(310-312)tcC>tcT	p.S104S	PARP8_ENST00000511363.2_Intron|PARP8_ENST00000505554.1_Silent_p.S83S|PARP8_ENST00000503750.2_Silent_p.S104S|PARP8_ENST00000514342.2_5'UTR|PARP8_ENST00000505697.2_Silent_p.S104S|PARP8_ENST00000514067.2_Silent_p.S104S	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	104						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				GTTGCTTATCCATAAAATCCA	0.234000													8	44					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129209148	129209148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129209148C>T	ENST00000280333.6	+	43	4434	c.4325C>T	c.(4324-4326)cCa>cTa	p.P1442L		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1442	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TATTCTCGGCCAATCCGGAAG	0.408000													11	29					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33985438	33985438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33985438G>A	ENST00000373381.4	-	69	10886	c.10710C>T	c.(10708-10710)ggC>ggT	p.G3570G		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3426						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGAGCACGAAGCCCGCAATAA	0.627000													15	53					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57335885	57335885	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57335885G>A	ENST00000326441.9	-	4	502	c.139C>T	c.(139-141)Cag>Tag	p.Q47*	PEG3_ENST00000594706.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Intron|PEG3_ENST00000593695.1_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Nonsense_Mutation_p.Q47*	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	47	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CGAAACCTCTGATGAAAAAAC	0.502000													13	56					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2842728	2842728	+	Silent	SNP	C	C	T	rs141872607		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2842728C>T	ENST00000380445.3	+	11	1095	c.1023C>T	c.(1021-1023)gcC>gcT	p.A341A	VPS16_ENST00000380469.3_Intron|VPS16_ENST00000481812.2_Intron	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	341					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome		p.A341A(1)		NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						TCAAAATTGCCTCAATGGCCC	0.597000													13	18					0	0	1	0	0
CD81	975	broad.mit.edu	37	11	2416230	2416230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2416230C>T	ENST00000263645.5	+	4	564	c.308C>T	c.(307-309)gCc>gTc	p.A103V	CD81_ENST00000381036.3_Missense_Mutation_p.A141V|CD81_ENST00000492627.1_Missense_Mutation_p.A32V|CD81_ENST00000526072.1_Missense_Mutation_p.A32V|CD81_ENST00000524805.1_3'UTR|CD81_ENST00000481687.1_Missense_Mutation_p.A109V	NM_004356.3	NP_004347.1	P60033	CD81_HUMAN	CD81 molecule	103					activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding			endometrium(1)|lung(3)|skin(1)	5		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		ATCCTGTTTGCCTGTGAGGTG	0.662000													33	60					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091567	9091567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9091567G>A	ENST00000397910.4	-	1	451	c.248C>T	c.(247-249)tCc>tTc	p.S83F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	83	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGAGCAGAGGACATCACCCC	0.532000													32	87					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61255990	61255990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61255990C>T	ENST00000344731.5	+	2	191	c.89C>T	c.(88-90)tCc>tTc	p.S30F	SERPINB13_ENST00000269489.5_Missense_Mutation_p.S30F	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	30					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						ATCTTCTTTTCCCCTGTGGGC	0.532000													15	56					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15880873	15880873	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15880873C>T	ENST00000595525.1	+	0	529				CYP4F24P_ENST00000587443.2_RNA																							CTCTGAAGGTCCGATCTTCTT	0.493000													4	14					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11189841	11189841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11189841G>A	ENST00000361445.4	-	40	5744	c.5668C>T	c.(5668-5670)Cgt>Tgt	p.R1890C	MTOR_ENST00000376838.1_Missense_Mutation_p.R95C	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1890	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GAGATGGAACGGAAGAAGCCC	0.522000													10	55					0	0	1	0	0
DGKE	8526	broad.mit.edu	37	17	54925355	54925355	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54925355C>T	ENST00000284061.3	+	5	997	c.817C>T	c.(817-819)Cga>Tga	p.R273*		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	273	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					TTATTCAGCTCGAGTACTTGT	0.388000													22	77					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99358502	99358502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99358502C>T	ENST00000354593.2	-	7	1009	c.906G>A	c.(904-906)atG>atA	p.M302I	CYP3A4_ENST00000336411.2_Missense_Mutation_p.M452I			P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	452					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	GAGCAAGTTTCATGTTCATGA	0.363000													65	147					0	0	1	0	0
REEP2	51308	broad.mit.edu	37	5	137780194	137780194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137780194C>T	ENST00000378339.2	+	4	465	c.273C>T	c.(271-273)ttC>ttT	p.F91F	REEP2_ENST00000254901.5_Silent_p.F91F|REEP2_ENST00000506158.1_Silent_p.F53F	NM_001271803.1	NP_001258732.1	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	91						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACCGCAAGTTCGTGCACCCAA	0.587000													16	59					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242755876	242755876	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242755876C>T	ENST00000391969.2	+	3	906	c.195C>T	c.(193-195)tcC>tcT	p.S65S	NEU4_ENST00000405370.1_Silent_p.S65S|NEU4_ENST00000404257.1_Silent_p.S77S|NEU4_ENST00000407683.1_Silent_p.S65S|NEU4_ENST00000325935.6_Silent_p.S78S	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	65						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CCGGGGGCTCCGTGCGGGTGA	0.746000													3	6					0	0	1	0	0
LEPREL4	10609	broad.mit.edu	37	17	39964117	39964117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39964117G>A	ENST00000355468.3	-	6	1522	c.1056C>T	c.(1054-1056)ccC>ccT	p.P352P	LEPREL4_ENST00000393928.1_Silent_p.P352P			Q92791	SC65_HUMAN	leprecan-like 4	352	Asp/Glu-rich (acidic).				synaptonemal complex assembly	nucleolus|synaptonemal complex	binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8						CCACCTCCCGGGGCTGGAAGT	0.597000													26	20					0	0	1	0	0
HORMAD2	150280	broad.mit.edu	37	22	30489904	30489904	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30489904G>A	ENST00000336726.6	+	2	318		c.e2-1		HORMAD2_ENST00000403975.1_Splice_Site	NM_152510.2	NP_689723.1	Q8N7B1	HORM2_HUMAN	HORMA domain containing 2						meiosis|mitosis	chromosome|nucleus				large_intestine(1)|lung(1)	2			Epithelial(10;0.125)			ttttttaataGGTTGGACTTG	0.338000													8	10					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103343647	103343647	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103343647G>A	ENST00000358392.2	-	67	5702	c.5385C>T	c.(5383-5385)gtC>gtT	p.V1795V	COL11A1_ENST00000512756.1_Silent_p.V1667V|COL11A1_ENST00000353414.4_Silent_p.V1744V|COL11A1_ENST00000370096.3_Silent_p.V1783V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1783	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CATTGATCATGACATCAACAA	0.323000													35	62					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10088351	10088351	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10088351C>T	ENST00000287647.3	+	15	1315	c.1222C>T	c.(1222-1224)Cga>Tga	p.R408*	FANCD2_ENST00000383807.1_Nonsense_Mutation_p.R408*|FANCD2_ENST00000419585.1_Nonsense_Mutation_p.R408*|FANCD2_ENST00000383806.1_Nonsense_Mutation_p.R408*	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	408					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AAATAAGATTCGATCAGGCTG	0.368000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				25	116					0	0	1	0	0
CHST14	113189	broad.mit.edu	37	15	40764056	40764056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40764056C>T	ENST00000306243.5	+	1	897	c.644C>T	c.(643-645)cCc>cTc	p.P215L	CHST14_ENST00000559991.1_Missense_Mutation_p.P190L	NM_130468.3	NP_569735.1	Q8NCH0	CHSTE_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	215					carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding			cervix(1)|large_intestine(1)|prostate(2)	4		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		GTGCGGGAGCCCTTGGAACGC	0.592000													29	104					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234460143	234460143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234460143G>A	ENST00000251722.6	-	7	833	c.716C>T	c.(715-717)cCt>cTt	p.P239L	USP40_ENST00000450966.1_Missense_Mutation_p.P251L|USP40_ENST00000427112.2_Missense_Mutation_p.P239L			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	239					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		AAGAAAAGGAGGCAGCTTACG	0.318000													4	12					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	35993773	35993773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35993773G>A	ENST00000339686.3	-	10	1326	c.1150C>T	c.(1150-1152)Ccc>Tcc	p.P384S	DMKN_ENST00000472252.2_Missense_Mutation_p.P31S|DMKN_ENST00000602781.1_Missense_Mutation_p.P97S|DMKN_ENST00000467637.1_Missense_Mutation_p.P109S|DMKN_ENST00000492341.2_Missense_Mutation_p.P31S|DMKN_ENST00000419602.1_Missense_Mutation_p.P373S|DMKN_ENST00000402589.2_Missense_Mutation_p.P97S|DMKN_ENST00000443640.1_Missense_Mutation_p.P147S|DMKN_ENST00000480502.1_Intron|DMKN_ENST00000436012.1_Missense_Mutation_p.P80S|DMKN_ENST00000462126.1_5'UTR|DMKN_ENST00000429837.1_Missense_Mutation_p.P343S|DMKN_ENST00000414866.2_Missense_Mutation_p.P97S	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	384						extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGGGTGCTGGGGGGCGGGACC	0.622000													18	44					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50220340	50220340	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50220340G>A	ENST00000002829.3	+	10	1391	c.907G>A	c.(907-909)Gat>Aat	p.D303N	SEMA3F_ENST00000413852.1_Missense_Mutation_p.D204N|SEMA3F_ENST00000434342.1_Missense_Mutation_p.D272N	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	303	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CCCCCAGAACGATGACGGTGG	0.617000													5	21					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980866	40980866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40980866C>T	ENST00000373198.3	-	10	1855	c.1620G>A	c.(1618-1620)ggG>ggA	p.G540G	PTPRT_ENST00000373187.1_Silent_p.G540G|PTPRT_ENST00000373193.3_Silent_p.G540G|PTPRT_ENST00000373201.1_Silent_p.G540G|PTPRT_ENST00000373184.1_Silent_p.G540G|PTPRT_ENST00000356100.2_Silent_p.G540G|PTPRT_ENST00000373190.1_Silent_p.G540G	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	540	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGAACACTTTCCCCCTCTGGC	0.527000													29	90					0	0	1	0	0
FOXRED2	80020	broad.mit.edu	37	22	36900680	36900680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36900680G>A	ENST00000397224.4	-	3	754	c.661C>T	c.(661-663)Cgt>Tgt	p.R221C	FOXRED2_ENST00000397223.4_Missense_Mutation_p.R221C|FOXRED2_ENST00000216187.6_Missense_Mutation_p.R221C	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	221					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GAGTTCCCACGACCCAGGATC	0.567000													18	45					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45224880	45224880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45224880G>A	ENST00000279027.4	-	5	728	c.710C>T	c.(709-711)tCc>tTc	p.S237F	SLC13A3_ENST00000472148.1_Missense_Mutation_p.S190F|SLC13A3_ENST00000396360.1_Missense_Mutation_p.S190F|SLC13A3_ENST00000372121.1_Missense_Mutation_p.P215S|SLC13A3_ENST00000495082.1_Missense_Mutation_p.S190F|SLC13A3_ENST00000435032.1_5'UTR|SLC13A3_ENST00000290317.5_Missense_Mutation_p.S190F|SLC13A3_ENST00000413164.2_Missense_Mutation_p.P215S	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	237						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	GTAGGGGATGGAGATGAGGAA	0.577000													35	93					0	0	1	0	0
TMEM8A	58986	broad.mit.edu	37	16	427062	427062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:427062G>A	ENST00000431232.2	-	4	770	c.610C>T	c.(610-612)Ctc>Ttc	p.L204F	TMEM8A_ENST00000250930.3_Missense_Mutation_p.L11F	NM_021259.2	NP_067082.2	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A	204					cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						TGGGAGAGGAGGGTCTGAGGA	0.657000											OREG0003703	type=REGULATORY REGION|Gene=TMEM8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	47					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106680917	106680917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:106680917G>A	ENST00000526355.1	-	5	1962	c.1494C>T	c.(1492-1494)ttC>ttT	p.F498F	GUCY1A2_ENST00000282249.2_Silent_p.F498F|GUCY1A2_ENST00000347596.2_Silent_p.F519F	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	498					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		CATCACCAGGGAAAATAGAAT	0.418000													20	77					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584837	7584837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7584837G>A	ENST00000379802.3	+	24	7683	c.7342G>A	c.(7342-7344)Gaa>Aaa	p.E2448K	DSP_ENST00000418664.2_Missense_Mutation_p.E1849K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2448	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCCTCTGAAAGAAAAGAAGAA	0.403000													38	87					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890592	229890592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:229890592G>A	ENST00000392054.3	-	4	842	c.503C>T	c.(502-504)aCc>aTc	p.T168I	PID1_ENST00000392055.3_Missense_Mutation_p.T137I|PID1_ENST00000482518.2_Intron|PID1_ENST00000409462.1_Missense_Mutation_p.T88I|PID1_ENST00000354069.6_Missense_Mutation_p.T170I	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	170	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GTGGTCGGCGGTGCAGTAGGC	0.587000													39	84					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11319416	11319416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11319416G>A	ENST00000294618.7	-	39	5045	c.5034C>T	c.(5032-5034)ttC>ttT	p.F1678F	DOCK6_ENST00000319867.7_Silent_p.F1017F|CTC-510F12.2_ENST00000588634.1_RNA	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1678	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CCAGCTCAGTGAAGTGCTTCC	0.642000													18	44					0	0	1	0	0
TRAT1	50852	broad.mit.edu	37	3	108541781	108541781	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108541781G>A	ENST00000295756.6	+	1	237	c.7_splice	c.e1+1	p.G3_splice	TRAT1_ENST00000493604.1_3'UTR|TRAT1_ENST00000426646.1_Splice_Site_p.D3_splice	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	3					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						AAGCATGTCAGGTAAGTGGCA	0.313000													39	128					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31405603	31405603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31405603G>A	ENST00000389202.2	+	2	127	c.78G>A	c.(76-78)acG>acA	p.T26T		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	26					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						AGGAGCCTACGATCTTCCAGG	0.572000													16	48					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220161176	220161176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220161176G>A	ENST00000295718.2	-	17	2613	c.2373C>T	c.(2371-2373)atC>atT	p.I791I	PTPRN_ENST00000497977.1_5'UTR|PTPRN_ENST00000409251.3_Silent_p.I762I|PTPRN_ENST00000423636.2_Silent_p.I701I	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	791	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		AGAAGTCTGCGATGGTATGGG	0.602000													31	78					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99506319	99506319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99506319C>T	ENST00000355947.2	-	4	813	c.684G>A	c.(682-684)acG>acA	p.T228T	TRIM4_ENST00000349062.2_Silent_p.T202T|TRIM4_ENST00000354241.5_Silent_p.T202T	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	228					protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				GCTTCTTCTTCGTCTCTTCTT	0.448000													37	115					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24436904	24436904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24436904C>T	ENST00000230036.1	-	22	2368	c.2258G>A	c.(2257-2259)gGa>gAa	p.G753E		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	753						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						GCCGTCTTCTCCCCCAATCAG	0.443000													28	74					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49823408	49823408	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49823408C>T	ENST00000561648.1	-	2	119	c.66G>A	c.(64-66)gtG>gtA	p.V22V	ZNF423_ENST00000562520.1_5'UTR|ZNF423_ENST00000563137.2_5'UTR|ZNF423_ENST00000262383.2_Silent_p.V22V	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	22					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CTGCTGCTGTCACGGAGGAAT	0.572000													5	54					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740411	140740411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140740411G>A	ENST00000522605.1	+	1	709	c.709G>A	c.(709-711)Gat>Aat	p.D237N	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATGCCAACGATAACCCTCC	0.567000													24	61					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394955	154394955	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154394955C>T	ENST00000435029.4	+	1	1696	c.1536C>T	c.(1534-1536)acC>acT	p.T512T		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	512					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACGCTTTTACCACTCAGCATG	0.488000													30	78					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848098	215848098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215848098C>T	ENST00000366943.2	-	63	13541	c.13155G>A	c.(13153-13155)aaG>aaA	p.K4385K	USH2A_ENST00000307340.3_Silent_p.K4385K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4385	Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTTAGTAATCTTTCCATTTT	0.478000										HNSCC(13;0.011)			7	71					0	0	1	0	0
CCND2	894	broad.mit.edu	37	12	4387925	4387925	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4387925G>A	ENST00000261254.3	+	3	680		c.e3-1			NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2						cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			TTCCCCTCCAGGAGTGGGAAC	0.572000			T	IGL@	"""NHL,CLL"""								10	79					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3675458	3675458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3675458C>T	ENST00000344754.4	-	11	2795	c.2796G>A	c.(2794-2796)cgG>cgA	p.R932R	SIGLEC1_ENST00000202578.4_Silent_p.R932R	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	932	Ig-like C2-type 9.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCTGGCCATCCCGATACCAAC	0.612000													25	58					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4249749	4249749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4249749C>T	ENST00000404826.2	+	38	5633	c.5494C>T	c.(5494-5496)Ctg>Ttg	p.L1832L	SDK1_ENST00000389531.3_Silent_p.L1812L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1832	Fibronectin type-III 12.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAACGGCATCCTGCAGGGCTA	0.667000													10	58					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711073	58711073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58711073G>A	ENST00000300079.5	+	2	132	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_5'UTR	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	agcgcgaagtgaacacggaag	0.453000													9	39					0	0	1	0	0
CLDN23	137075	broad.mit.edu	37	8	8560001	8560001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8560001G>A	ENST00000519106.1	+	1	554	c.93G>A	c.(91-93)cgG>cgA	p.R31R		NM_194284.2	NP_919260.2	Q96B33	CLD23_HUMAN	claudin 23	31					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)	2		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		CCGGCTGGCGGCTGGTGAAGG	0.706000													5	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179571376	179571376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179571376C>T	ENST00000589042.1	-	102	29449	c.29225G>A	c.(29224-29226)gGa>gAa	p.G9742E	TTN_ENST00000342992.6_Missense_Mutation_p.G8498E|TTN_ENST00000591111.1_Missense_Mutation_p.G9425E|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9425	Ig-like 78.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACACGACCTCCTTGGTTCAG	0.443000													64	131					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755243	140755243	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140755243G>A	ENST00000517434.1	+	1	1593	c.1593G>A	c.(1591-1593)tgG>tgA	p.W531*	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAGCTGTGGGTGACAGCCA	0.597000													65	228					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57553764	57553764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57553764C>T	ENST00000243077.3	+	12	2421	c.1955C>T	c.(1954-1956)gCt>gTt	p.A652V		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	652					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CACCCCAGGGCTATTGTGGTG	0.562000													12	41					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78784639	78784639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78784639G>A	ENST00000545128.1	+	13	2177	c.1639G>A	c.(1639-1641)Gaa>Aaa	p.E547K	PCSK5_ENST00000376767.3_Missense_Mutation_p.E547K|PCSK5_ENST00000376752.4_Missense_Mutation_p.E547K	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	547	Homo B/P.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TCACTCCATGGAAGGATTCAA	0.413000													27	100					0	0	1	0	0
TNPO3	23534	broad.mit.edu	37	7	128615974	128615974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128615974G>A	ENST00000393245.1	-	17	2552	c.2179C>T	c.(2179-2181)Cac>Tac	p.H727Y	TNPO3_ENST00000471166.1_Missense_Mutation_p.H727Y|TNPO3_ENST00000265388.5_Missense_Mutation_p.H693Y|TNPO3_ENST00000482320.1_Missense_Mutation_p.H627Y|TNPO3_ENST00000471234.1_Missense_Mutation_p.H629Y	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	693					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						TGATGTACGTGGTACACATTC	0.453000													19	49					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60074101	60074101	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:60074101G>A	ENST00000267484.5	-	4	2210	c.1875C>T	c.(1873-1875)gcC>gcT	p.A625A	RTN1_ENST00000342503.4_Silent_p.A57A|RTN1_ENST00000395090.1_Silent_p.A42A|RTN1_ENST00000557422.1_5'UTR	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	625	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GGGCCAGGTAGGCCACGACGC	0.557000													5	53					0	0	1	0	0
RCN1	5954	broad.mit.edu	37	11	32125929	32125929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:32125929G>A	ENST00000054950.3	+	6	1200	c.907G>A	c.(907-909)Gag>Aag	p.E303K	RP1-65P5.3_ENST00000533009.1_RNA|RCN1_ENST00000532942.1_Missense_Mutation_p.E252K	NM_002901.2	NP_002892.1	Q15293	RCN1_HUMAN	reticulocalbin 1, EF-hand calcium binding domain	303	EF-hand 6.					endoplasmic reticulum lumen	calcium ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)	17	Lung SC(675;0.225)					GCTAACTAAAGAGGAAATATT	0.398000													10	19					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14022146	14022146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:14022146G>A	ENST00000382080.1	-	5	1205	c.490C>T	c.(490-492)Ctg>Ttg	p.L164L	RP11-3G21.1_ENST00000527110.1_RNA|SGCZ_ENST00000421524.2_Silent_p.L117L	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	151					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GCAGAAAACAGCACCCTGCCA	0.408000													10	72					0	0	1	0	0
TMEM63C	57156	broad.mit.edu	37	14	77715711	77715711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77715711G>A	ENST00000298351.4	+	21	2092	c.1948G>A	c.(1948-1950)Gag>Aag	p.E650K		NM_020431.2	NP_065164.2	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	650						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(1)	23			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CAAACTGAACGAGCAGATCCA	0.532000													31	75					0	0	1	0	0
NR1I3	9970	broad.mit.edu	37	1	161205715	161205715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161205715C>T	ENST00000367983.4	-	3	454	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	NR1I3_ENST00000367985.3_Missense_Mutation_p.E54K|NR1I3_ENST00000428574.2_Missense_Mutation_p.E54K|NR1I3_ENST00000367982.4_Missense_Mutation_p.E54K|NR1I3_ENST00000367980.2_Missense_Mutation_p.E54K|NR1I3_ENST00000367984.4_Missense_Mutation_p.E54K|NR1I3_ENST00000367981.3_Missense_Mutation_p.E25K|NR1I3_ENST00000367979.2_Missense_Mutation_p.E54K|NR1I3_ENST00000511676.1_Missense_Mutation_p.E25K|NR1I3_ENST00000511944.1_Missense_Mutation_p.E54K|NR1I3_ENST00000515452.1_Missense_Mutation_p.E54K|NR1I3_ENST00000442691.2_Missense_Mutation_p.E54K|NR1I3_ENST00000515621.1_5'UTR|NR1I3_ENST00000505005.1_Missense_Mutation_p.E54K|NR1I3_ENST00000502985.1_Missense_Mutation_p.E54K|NR1I3_ENST00000508740.1_Missense_Mutation_p.E25K|NR1I3_ENST00000412844.2_Missense_Mutation_p.E25K|NR1I3_ENST00000437437.2_Missense_Mutation_p.E25K|NR1I3_ENST00000504010.1_Missense_Mutation_p.E25K|NR1I3_ENST00000512372.1_Missense_Mutation_p.E25K|NR1I3_ENST00000511748.1_Missense_Mutation_p.E25K|NR1I3_ENST00000508387.1_Missense_Mutation_p.E25K|NR1I3_ENST00000506209.1_Missense_Mutation_p.E25K			Q14994	NR1I3_HUMAN	nuclear receptor subfamily 1, group I, member 3	54					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	15	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TTGCTGACTTCACAGCTTCCA	0.532000													14	65					0	0	1	0	0
MICA	100507436	broad.mit.edu	37	6	31378943	31378943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31378943C>T	ENST00000449934.2	+	3	474	c.420C>T	c.(418-420)ttC>ttT	p.F140F	HCP5_ENST00000414046.2_RNA	NM_001177519.1	NP_001170990.1	Q29983	MICA_HUMAN	MHC class I polypeptide-related sequence A	140					antigen processing and presentation|cytolysis|defense response to bacterium|defense response to virus|gamma-delta T cell activation|immune response to tumor cell|response to DNA damage stimulus|response to heat|stimulatory C-type lectin receptor signaling pathway	cell surface|cytoplasm|extracellular space|integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding	p.F140F(1)		breast(1)|endometrium(3)|kidney(1)	5		Ovarian(999;0.0253)				GGGAGCTCTTCCTCTCCCAAA	0.537000													12	17					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106917009	106917009	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106917009G>A	ENST00000369701.3	+	10	1823	c.1596G>A	c.(1594-1596)gtG>gtA	p.V532V		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	532						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTCCGGATGTGGACCTGAGAG	0.562000													5	57					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10204902	10204902	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10204902C>T	ENST00000418404.3	-	39	5949	c.5786G>A	c.(5785-5787)cGa>cAa	p.R1929Q	MYH13_ENST00000570743.1_Missense_Mutation_p.R1929Q|MYH13_ENST00000252172.4_Missense_Mutation_p.R1929Q			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1929					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GCCCACGTCTCGGCTCTTGGC	0.582000													17	140					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020566	5020566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5020566G>A	ENST00000321543.1	+	1	354	c.354G>A	c.(352-354)ctG>ctA	p.L118L		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGTGTTGCTGGCCATGGCCT	0.498000													65	145					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39394370	39394370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39394370G>A	ENST00000545653.1	-	2	583	c.53C>T	c.(52-54)gCc>gTc	p.A18V	DAB2_ENST00000509337.1_Missense_Mutation_p.A18V|DAB2_ENST00000339788.6_Missense_Mutation_p.A18V|DAB2_ENST00000320816.6_Missense_Mutation_p.A18V	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	18					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			TTTTGGTGCGGCCTGTTGGTC	0.493000													31	59					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2812786	2812786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2812786C>T	ENST00000301740.8	+	11	2806	c.2257C>T	c.(2257-2259)Cgc>Tgc	p.R753C		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	753	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						GAAGAAATCTCGCATTTCTTC	0.488000													37	112					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55127312	55127312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55127312G>A	ENST00000257290.5	+	3	431	c.100G>A	c.(100-102)Gaa>Aaa	p.E34K	PDGFRA_ENST00000508170.1_Missense_Mutation_p.E34K|FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	34	Ig-like C2-type 1.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CCTTCCAAATGAAAATGAAAA	0.473000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			32	139					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35477696	35477696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35477696C>T	ENST00000229771.6	-	6	588	c.509G>A	c.(508-510)gGa>gAa	p.G170E	TULP1_ENST00000322263.4_Missense_Mutation_p.G117E	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	170					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						GTCAGGGCTTCCCAGGTCTCC	0.567000													39	106					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581303	140581303	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140581303C>T	ENST00000354757.3	+	1	1956	c.1956C>T	c.(1954-1956)cgC>cgT	p.R652R	PCDHB11_ENST00000536699.1_Silent_p.R287R	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		652	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCCTCCGCGCTCGGCCACCG	0.721000													21	57					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102668758	102668758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102668758C>T	ENST00000315274.6	-	1	133	c.66G>A	c.(64-66)gcG>gcA	p.A22A	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	22					blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		TTTCTAGAGTCGCTGGGAAGC	0.443000													16	27					0	0	1	0	0
FASTKD2	22868	broad.mit.edu	37	2	207636626	207636626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207636626C>T	ENST00000236980.6	+	5	1347	c.999C>T	c.(997-999)gcC>gcT	p.A333A	FASTKD2_ENST00000402774.3_Silent_p.A333A|FASTKD2_ENST00000403094.3_Silent_p.A333A	NM_014929.3	NP_055744.2	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	333					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(2)	21				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		AGATGAAAGCCTTGAGGGAAT	0.323000													13	58					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566226	5566226	+	Silent	SNP	G	G	A	rs35658346		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5566226G>A	ENST00000322653.4	-	1	553	c.528C>T	c.(526-528)ttC>ttT	p.F176F	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGTCCTGCAGAAAGGCAGGC	0.493000													20	42					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124210210	124210210	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124210210C>T	ENST00000360013.3	+	31	4749	c.4622C>T	c.(4621-4623)cCc>cTc	p.P1541L	KALRN_ENST00000240874.3_Missense_Mutation_p.P1541L|KALRN_ENST00000460856.1_Missense_Mutation_p.P1532L	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1541	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GAGGGCGATCCCTGCAAATTC	0.562000													16	46					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70987031	70987031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70987031G>A	ENST00000354624.5	+	2	265	c.132G>A	c.(130-132)cgG>cgA	p.R44R	HKDC1_ENST00000395086.2_Silent_p.R44R|RP11-227H15.4_ENST00000450995.1_RNA	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	44					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						GGCGGTTCCGGGCTGAGATGG	0.597000													36	79					0	0	1	0	0
SMC5	23137	broad.mit.edu	37	9	72967122	72967122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72967122C>T	ENST00000361138.5	+	25	3239	c.3181C>T	c.(3181-3183)Cct>Tct	p.P1061S	SMC5_ENST00000471372.1_3'UTR	NM_015110.3	NP_055925.2	Q8IY18	SMC5_HUMAN	structural maintenance of chromosomes 5	1061					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(4)	35						GCAAAATCTTCCTTATTCTGA	0.378000													37	96					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13701487	13701487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13701487C>T	ENST00000265104.4	-	77	13501	c.13397G>A	c.(13396-13398)aGc>aAc	p.S4466N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4466					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGTAAACTGGCTGTTTCTTTC	0.393000									Kartagener syndrome				18	115					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36634028	36634028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:36634028G>A	ENST00000431169.1	-	12	1155	c.855C>T	c.(853-855)ttC>ttT	p.F285F	AOAH_ENST00000535891.1_Silent_p.F253F|AOAH_ENST00000258749.5_Silent_p.F285F|AOAH_ENST00000538464.1_Silent_p.F7F	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	285					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GTAGATTGATGAAAGAGTTCT	0.413000													25	42					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99441632	99441632	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:99441632C>T	ENST00000287042.4	+	2	1775	c.1425C>T	c.(1423-1425)tcC>tcT	p.S475S	KCNS2_ENST00000521839.1_Silent_p.S475S	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	475						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TAAATGATTCCCTACGTTAGC	0.493000													15	55					0	0	1	0	0
ARMC2	84071	broad.mit.edu	37	6	109190152	109190152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:109190152C>T	ENST00000392644.4	+	4	585	c.417C>T	c.(415-417)gcC>gcT	p.A139A	ARMC2_ENST00000368972.3_5'UTR	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	139							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		TCAGGGCTGCCTCCCAGCGGG	0.552000													21	34					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45537767	45537767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45537767C>T	ENST00000221452.8	+	11	1485	c.1335C>T	c.(1333-1335)ttC>ttT	p.F445F	RELB_ENST00000505236.1_Silent_p.F442F|RELB_ENST00000540120.1_Silent_p.F445F	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	445						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		TGGACCACTTCCTGCCCAACC	0.622000													5	11					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88027614	88027614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88027614C>T	ENST00000227266.5	-	7	1066	c.952G>A	c.(952-954)Gaa>Aaa	p.E318K		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	318					immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAAGCTTCTTCCACCAGCCCA	0.463000													16	77					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54416286	54416286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54416286C>T	ENST00000296733.1	-	10	1482	c.1308G>A	c.(1306-1308)ggG>ggA	p.G436G	CDC20B_ENST00000381375.2_Silent_p.G436G|CDC20B_ENST00000322374.6_Intron|CDC20B_ENST00000334206.5_3'UTR	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	436										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			GGATGCTCTTCCCAGCATTTA	0.453000													49	109					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77455135	77455135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77455135C>T	ENST00000451710.3	-	5	586	c.349G>A	c.(349-351)Gat>Aat	p.D117N	TRPM6_ENST00000376864.4_Missense_Mutation_p.D117N|TRPM6_ENST00000361255.3_Missense_Mutation_p.D112N|TRPM6_ENST00000360774.1_Missense_Mutation_p.D117N|TRPM6_ENST00000376871.3_Missense_Mutation_p.D117N|TRPM6_ENST00000376872.3_Missense_Mutation_p.D117N|TRPM6_ENST00000449912.2_Missense_Mutation_p.D112N|TRPM6_ENST00000359047.2_Missense_Mutation_p.D117N			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	117					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AGTTTTGTATCATAAGAAGTT	0.403000													15	26					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487829	248487829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248487829G>A	ENST00000317965.2	-	1	70	c.42C>T	c.(40-42)ctC>ctT	p.L14L		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGATTCCCAGGAGGAGGAAGT	0.453000													24	303					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104302572	104302572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104302572C>T	ENST00000389120.3	+	3	307	c.217C>T	c.(217-219)Cgt>Tgt	p.R73C		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	73					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AGATGAACTTCGTGAGCACAT	0.453000													36	121					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44030298	44030298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44030298C>T	ENST00000269439.7	+	5	706	c.655C>T	c.(655-657)Cac>Tac	p.H219Y	RNF165_ENST00000543885.1_Missense_Mutation_p.H27Y	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	219							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		CCCTCAGCTTCACTTCCTTGC	0.522000													20	100					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890618	229890618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:229890618G>A	ENST00000392054.3	-	4	816	c.477C>T	c.(475-477)ttC>ttT	p.F159F	PID1_ENST00000392055.3_Silent_p.F128F|PID1_ENST00000482518.2_Intron|PID1_ENST00000409462.1_Silent_p.F79F|PID1_ENST00000354069.6_Silent_p.F161F	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	161	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GGGCCACCTGGAAGGTATCCA	0.572000													29	75					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171174688	171174688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171174688C>T	ENST00000441535.1	+	7	1215	c.1098C>T	c.(1096-1098)ctC>ctT	p.L366L	RP1-127D3.4_ENST00000422841.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000209929.7_Silent_p.L366L|RP1-127D3.4_ENST00000445290.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	366					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGTCAACCCTCGCGTGCATTG	0.448000													24	83					0	0	1	0	0
TPRG1	285386	broad.mit.edu	37	3	188956634	188956634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:188956634C>T	ENST00000345063.3	+	4	582	c.415C>T	c.(415-417)Cct>Tct	p.P139S	TPRG1_ENST00000433971.1_Missense_Mutation_p.P139S|TPRG1-AS2_ENST00000425454.1_RNA	NM_198485.3	NP_940887.1	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	139										endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|skin(2)|urinary_tract(1)	16	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		GCAGCGGATTCCTCTGAGCGC	0.478000													36	99					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469386	72469386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:72469386G>A	ENST00000296776.5	+	1	365	c.316G>A	c.(316-318)Gaa>Aaa	p.E106K	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	106						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		AGAAAGTGAGGAAAGGGTCCC	0.532000													29	84					0	0	1	0	0
IGLV3-1	28809	broad.mit.edu	37	22	23223458	23223458	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23223458C>T	ENST00000390319.2	+	0	280																											CCTCAGGGATCCCTGAGCGAT	0.547000													28	59					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25287187	25287187	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25287187C>T	ENST00000552781.1	+	0	328				SNORD109A_ENST00000459128.1_RNA																							ATCTGAGGTCCAGATGTGTGG	0.468000													6	22					0	0	1	0	0
CBR4	84869	broad.mit.edu	37	4	169923281	169923281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169923281G>A	ENST00000306193.3	-	4	644	c.476C>T	c.(475-477)tCa>tTa	p.S159L	CBR4_ENST00000504480.1_Missense_Mutation_p.S159L|CBR4_ENST00000509108.1_5'UTR	NM_032783.4	NP_116172.2	Q8N4T8	CBR4_HUMAN	carbonyl reductase 4	159					fatty acid biosynthetic process|protein homotetramerization	mitochondrial matrix	NADPH binding|NADPH dehydrogenase (quinone) activity|protein binding|quinone binding			kidney(1)|large_intestine(2)|lung(2)	5		Prostate(90;0.00263)|Renal(120;0.0183)|Melanoma(52;0.123)		GBM - Glioblastoma multiforme(119;0.0321)		AAGAGCACGTGAAAATCCAAC	0.343000													16	58					0	0	1	0	0
RHBDL3	162494	broad.mit.edu	37	17	30648242	30648242	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:30648242C>T	ENST00000269051.4	+	9	1223	c.1209C>T	c.(1207-1209)ccC>ccT	p.P403P	RHBDL3_ENST00000538145.1_Silent_p.P395P|RHBDL3_ENST00000536287.1_Silent_p.P305P	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	403					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				TGCCGCCTCCCCCCTGAGGGC	0.597000													20	19					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121414362	121414362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121414362C>T	ENST00000260197.7	+	13	1920	c.1791C>T	c.(1789-1791)ttC>ttT	p.F597F	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	597					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GCACTGTCTTCACCATCTTTG	0.512000													47	106					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72111608	72111608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:72111608G>A	ENST00000340726.3	-	18	2385	c.1746C>T	c.(1744-1746)gcC>gcT	p.A582A	EYA1_ENST00000388742.4_Silent_p.A582A|RP11-326E22.1_ENST00000521685.1_RNA|EYA1_ENST00000388741.2_Silent_p.A548A|EYA1_ENST00000303824.7_Silent_p.A576A|EYA1_ENST00000419131.1_Silent_p.A547A|EYA1_ENST00000388743.2_Silent_p.A581A|EYA1_ENST00000388740.3_Silent_p.A549A	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	582					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CATGGTGCAGGGCCATGAGGT	0.617000													7	20					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179597800	179597800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:179597800G>A	ENST00000467460.1	-	5	752	c.422C>T	c.(421-423)gCc>gTc	p.A141V	PEX5L_ENST00000472994.1_Missense_Mutation_p.A82V|PEX5L_ENST00000468741.1_5'UTR|PEX5L_ENST00000464614.1_Intron|PEX5L_ENST00000392649.3_Intron|PEX5L_ENST00000263962.8_Missense_Mutation_p.A139V|PEX5L_ENST00000485199.1_Missense_Mutation_p.A106V|PEX5L_ENST00000476138.1_Missense_Mutation_p.A98V|PEX5L_ENST00000467440.2_Intron|PEX5L-AS1_ENST00000466064.1_RNA|PEX5L_ENST00000465751.1_Missense_Mutation_p.A117V	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	141					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AGATCCATCGGCCTTTTTCTT	0.517000													20	74					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94353077	94353077	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94353077G>A	ENST00000515393.1	-	2	831	c.832C>T	c.(832-834)Cga>Tga	p.R278*	MCTP1_ENST00000505208.1_Nonsense_Mutation_p.R57*|MCTP1_ENST00000429576.2_Nonsense_Mutation_p.R57*|MCTP1_ENST00000312216.8_Nonsense_Mutation_p.R57*	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	278	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTACCTCCTCGATCTCGAGCA	0.413000													60	124					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12726000	12726000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12726000C>T	ENST00000376221.1	+	4	478	c.478C>T	c.(478-480)Cct>Tct	p.P160S		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	160						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		CCACCATTCCCCTGCCCTTTT	0.527000													10	103					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79313613	79313613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79313613C>T	ENST00000305089.3	-	4	281	c.201G>A	c.(199-201)atG>atA	p.M67I		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	67	C-type lectin.				cell proliferation	extracellular region	sugar binding	p.M67I(2)		central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						TGCCTGAATTCATGTTCTGGC	0.498000													31	104					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730381	140730381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140730381G>A	ENST00000523390.1	+	1	554	c.554G>A	c.(553-555)gGa>gAa	p.G185E	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCCTGATGGAAGTAAATAT	0.468000													42	207					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183694775	183694775	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183694775C>T	ENST00000511685.1	+	23	5166	c.5043C>T	c.(5041-5043)atC>atT	p.I1681I	TENM3_ENST00000406950.2_Silent_p.I1681I|RP11-18D7.2_ENST00000513255.1_RNA					teneurin transmembrane protein 3																		TGTCCTCGATCGATTCTTTCT	0.463000													19	148					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55280709	55280709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55280709C>T	ENST00000358193.3	+	8	1101	c.1047C>T	c.(1045-1047)agC>agT	p.S349S	C1orf177_ENST00000371273.3_Silent_p.S349S	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	349										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						TTATGGGAAGCTGGGTAAGTG	0.542000													42	105					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16877460	16877460	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:16877460G>A	ENST00000355661.3	-	5	317	c.305_splice	c.e5-1	p.P103_splice	PLEKHA7_ENST00000448080.2_Splice_Site_p.P103_splice|PLEKHA7_ENST00000531066.1_Splice_Site_p.P103_splice|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	103					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TGTGGATTCGGCCTGTGAGGA	0.537000													54	159					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4855936	4855936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4855936G>A	ENST00000399583.3	-	8	2076	c.1889C>T	c.(1888-1890)cCc>cTc	p.P630L	RADIL_ENST00000536091.1_3'UTR|RADIL_ENST00000538469.1_Missense_Mutation_p.P390L	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	630	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGCCACCTCGGGGTGCACCTG	0.667000													7	14					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20129252	20129252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20129252C>T	ENST00000396085.1	+	37	7254	c.6893C>T	c.(6892-6894)tCg>tTg	p.S2298L	NAV2_ENST00000360655.4_Missense_Mutation_p.S2231L|NAV2_ENST00000311043.8_Missense_Mutation_p.S1359L|NAV2_ENST00000527559.2_Missense_Mutation_p.S2283L|NAV2_ENST00000349880.4_Missense_Mutation_p.S2295L|NAV2_ENST00000540292.1_Missense_Mutation_p.S2285L|NAV2_ENST00000533917.1_Missense_Mutation_p.S1359L|NAV2_ENST00000396087.3_Missense_Mutation_p.S2354L	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	2354						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GTGGACGGCTCGAGAGTGTGG	0.547000													134	318					0	0	1	0	0
AGBL2	79841	broad.mit.edu	37	11	47707561	47707561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47707561G>A	ENST00000525123.1	-	11	1957	c.1672C>T	c.(1672-1674)Cat>Tat	p.H558Y	AGBL2_ENST00000357610.3_Missense_Mutation_p.H558Y|AGBL2_ENST00000298861.4_Missense_Mutation_p.H558Y|AGBL2_ENST00000528244.1_Missense_Mutation_p.H520Y|AGBL2_ENST00000529712.1_5'UTR	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	558					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						CTGTGGCCATGGAAATCACAA	0.383000													41	68					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189910578	189910578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189910578C>T	ENST00000374866.3	-	46	3531	c.3257G>A	c.(3256-3258)gGa>gAa	p.G1086E		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1086					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent	p.G1086E(1)		NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCCAGGAGTTCCAGGGGCACC	0.498000													34	84					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129902393	129902393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129902393G>A	ENST00000368654.3	-	13	8086	c.7711C>T	c.(7711-7713)Cac>Tac	p.H2571Y	MKI67_ENST00000368653.3_Missense_Mutation_p.H2211Y	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2571	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCTTCAGTGTGACCTGGTGCT	0.483000													37	136					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170092404	170092404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170092404C>T	ENST00000263816.3	-	29	5151	c.4866G>A	c.(4864-4866)atG>atA	p.M1622I		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1622					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CACAAAAGTCCATGTAATCAA	0.443000													34	77					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232942	71232942	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:71232942C>T	ENST00000359042.2	+	3	1515	c.1321C>T	c.(1321-1323)Cag>Tag	p.Q441*	C17orf80_ENST00000255557.4_Nonsense_Mutation_p.Q441*|C17orf80_ENST00000426147.2_Nonsense_Mutation_p.Q441*|C17orf80_ENST00000535032.2_Nonsense_Mutation_p.Q441*|C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000268942.8_Nonsense_Mutation_p.Q441*|C17orf80_ENST00000577615.1_Nonsense_Mutation_p.Q441*	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	441						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			TCACACTCCTCAGAGCCCCTT	0.552000													31	67					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6730144	6730144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6730144C>T	ENST00000329858.4	-	2	1027	c.271G>A	c.(271-273)Gac>Aac	p.D91N	LPAR5_ENST00000431922.1_Missense_Mutation_p.D91N|LPAR5_ENST00000540335.1_5'UTR	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	91						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						CACAGGAGGTCGGGGAAGGGC	0.612000													5	18					0	0	1	0	0
ATG4B	23192	broad.mit.edu	37	2	242598552	242598552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242598552C>T	ENST00000405546.3	+	7	990	c.488C>T	c.(487-489)tCc>tTc	p.S163F	ATG4B_ENST00000474739.2_Missense_Mutation_p.S149F|ATG4B_ENST00000402096.1_Missense_Mutation_p.S89F|ATG4B_ENST00000396411.3_Missense_Mutation_p.S89F|ATG4B_ENST00000404914.3_Missense_Mutation_p.S163F			Q9Y4P1	ATG4B_HUMAN	autophagy related 4B, cysteine peptidase	163					autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		ACGTGGAGCTCCTTGGCGGTC	0.453000													12	24					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73678921	73678921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73678921C>T	ENST00000264448.6	+	8	5375	c.5264C>T	c.(5263-5265)tCc>tTc	p.S1755F	ALMS1_ENST00000409009.1_Missense_Mutation_p.S1713F|ALMS1_ENST00000377715.1_Missense_Mutation_p.S1755F	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1755	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ACTGTAACTTCCTCTTTCTAT	0.433000													14	138					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113241079	113241079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113241079G>A	ENST00000297405.5	-	70	11114	c.10870C>T	c.(10870-10872)Cat>Tat	p.H3624Y	CSMD3_ENST00000455883.2_Missense_Mutation_p.H3455Y|CSMD3_ENST00000343508.3_Missense_Mutation_p.H3584Y|CSMD3_ENST00000352409.3_Missense_Mutation_p.H3554Y	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3624						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTTGTACCATGAGGTTGATTT	0.279000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			29	60					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46998940	46998940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46998940C>T	ENST00000374314.4	+	1	1015	c.60C>T	c.(58-60)ccC>ccT	p.P20P	GPRIN2_ENST00000374317.1_Silent_p.P20P			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	20										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GCCTTCAGCCCCTGTCCCAGA	0.687000													9	134					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134670384	134670384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134670384C>T	ENST00000398015.3	+	3	665	c.295C>T	c.(295-297)Ctc>Ttc	p.L99F	EPHB1_ENST00000488154.1_3'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	99						integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CTGCAGCAGCCTCCCTAATGT	0.542000													19	37					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	144276933	144276933	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:144276933G>A	ENST00000295095.6	+	10	1092	c.925_splice	c.e10+1	p.G309_splice	RP11-570L15.2_ENST00000546678.1_RNA|RP11-570L15.1_ENST00000553076.1_RNA	NM_018460.3	NP_060930.3	Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	309	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGAGAAAAGAGGTGGGTGACT	0.453000													29	78					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22310278	22310278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22310278C>T	ENST00000337107.6	+	5	473	c.454C>T	c.(454-456)Ccc>Tcc	p.P152S		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	152	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						TGACATCCTTCCCAACGAGAC	0.622000													33	107					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72423500	72423500	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72423500G>A	ENST00000359373.5	-	6	1712	c.861C>T	c.(859-861)gcC>gcT	p.A287A	ARAP1_ENST00000393605.3_Silent_p.A47A|ARAP1_ENST00000426523.1_Silent_p.A42A|ARAP1_ENST00000429686.1_Silent_p.A42A|ARAP1_ENST00000334211.8_Silent_p.A42A|ARAP1_ENST00000455638.2_Silent_p.A287A|ARAP1_ENST00000393609.3_Silent_p.A287A			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	287					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						CGCCCTCATAGGCGTGGTCAT	0.687000													58	86					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95552654	95552654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95552654G>A	ENST00000371418.4	+	6	918	c.658G>A	c.(658-660)Gat>Aat	p.D220N	LGI1_ENST00000371413.3_Missense_Mutation_p.D220N|LGI1_ENST00000542308.1_Missense_Mutation_p.D172N	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	220	LRRCT.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				GAAGGATTTTGATTGCATCAT	0.388000													42	99					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58980191	58980191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58980191C>T	ENST00000361050.3	-	1	233	c.148G>A	c.(148-150)Ggc>Agc	p.G50S		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	50	MACPF.					integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				TTGTCCCAGCCCCCTCCAGGT	0.493000													71	157					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940423	144940423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144940423C>T	ENST00000525985.1	-	2	7070	c.6999G>A	c.(6997-6999)gaG>gaA	p.E2333E				P58107	EPIPL_HUMAN	epiplakin 1	2333						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGATGCCGTGCTCCCGGACGA	0.711000													24	339					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38776440	38776440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:38776440C>T	ENST00000308973.4	-	4	1377	c.772G>A	c.(772-774)Gac>Aac	p.D258N	TLR10_ENST00000508334.1_Missense_Mutation_p.D258N|TLR10_ENST00000361424.2_Missense_Mutation_p.D258N|TLR10_ENST00000506111.1_Missense_Mutation_p.D258N	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	258					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						AGGAAAAGGTCGTCCCAGAGT	0.353000													11	40					0	0	1	0	0
CLIC5	53405	broad.mit.edu	37	6	45882124	45882124	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:45882124C>T	ENST00000185206.6	-	5	1058	c.906G>A	c.(904-906)aaG>aaA	p.K302K	CLIC5_ENST00000339561.6_Silent_p.K143K|CLIC5_ENST00000544153.1_Silent_p.K143K|CLIC5_ENST00000486570.1_5'UTR	NM_001114086.1	NP_001107558.1	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5	302	GST C-terminal.				female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	13						TCTTTAGAGCCTTGGTTAGGC	0.493000													12	108					0	0	1	0	0
ST3GAL1	6482	broad.mit.edu	37	8	134472027	134472027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134472027G>A	ENST00000319914.5	-	9	2030	c.1003C>T	c.(1003-1005)Cgg>Tgg	p.R335W	ST3GAL1_ENST00000522652.1_Missense_Mutation_p.R335W|ST3GAL1_ENST00000399640.2_Missense_Mutation_p.R335W|ST3GAL1_ENST00000521180.1_Missense_Mutation_p.R335W			Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	335					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(3)|large_intestine(2)|lung(11)|prostate(1)	17	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			TTGAAGATCCGGATTTTATTG	0.572000													8	113					0	0	1	0	0
SNRPN	6638	broad.mit.edu	37	15	25223432	25223432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25223432C>T	ENST00000444203.2	+	7	1703	c.664C>T	c.(664-666)Ccg>Tcg	p.P222S	SNRPN_ENST00000554227.2_Missense_Mutation_p.P222S|SNRPN_ENST00000400100.1_Missense_Mutation_p.P218S|SNRPN_ENST00000400098.1_Missense_Mutation_p.P218S|SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000400097.1_Missense_Mutation_p.P218S|SNRPN_ENST00000346403.6_Missense_Mutation_p.P218S|SNRPN_ENST00000390687.4_Missense_Mutation_p.P218S|SNRPN_ENST00000577565.1_Missense_Mutation_p.P218S			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	218	Repeat-rich region.				RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		CATGCCGCCTCCGGGAATGAG	0.572000									Prader-Willi syndrome				47	150					0	0	1	0	0
CHMP4C	92421	broad.mit.edu	37	8	82670728	82670728	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:82670728G>A	ENST00000297265.4	+	5	844	c.651G>A	c.(649-651)agG>agA	p.R217R		NM_152284.3	NP_689497.1	Q96CF2	CHM4C_HUMAN	charged multivesicular body protein 4C	217	Intramolecular interaction with N- terminus (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	10						CTTCCCAGAGGGCAGAAGAAG	0.313000													19	85					0	0	1	0	0
GPR25	2848	broad.mit.edu	37	1	200842325	200842325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200842325C>T	ENST00000304244.2	+	1	243	c.160C>T	c.(160-162)Ctg>Ttg	p.L54L		NM_005298.2	NP_005289.2	O00155	GPR25_HUMAN	G protein-coupled receptor 25	54						integral to plasma membrane				large_intestine(1)|lung(2)|ovary(1)|skin(1)	5						CGCCGTGGGCCTGCTGGGCAA	0.721000													4	19					0	0	1	0	0
CDC25C	995	broad.mit.edu	37	5	137627780	137627780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137627780G>A	ENST00000323760.6	-	8	919	c.641C>T	c.(640-642)tCc>tTc	p.S214F	CDC25C_ENST00000514555.1_Missense_Mutation_p.S184F|CDC25C_ENST00000513970.1_Missense_Mutation_p.S214F|CDC25C_ENST00000356505.3_Missense_Mutation_p.S184F|CDC25C_ENST00000357274.3_Missense_Mutation_p.S171F|CDC25C_ENST00000348983.3_Missense_Mutation_p.S141F|CDC25C_ENST00000415130.2_Missense_Mutation_p.S141F	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	214					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CATCGACGGGGAGCGATATAG	0.438000													59	133					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69752175	69752175	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69752175G>A	ENST00000409085.4	-	10	1421	c.1045C>T	c.(1045-1047)Cca>Tca	p.P349S	AAK1_ENST00000406297.3_Missense_Mutation_p.P349S|AAK1_ENST00000409068.1_Missense_Mutation_p.P349S	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	349						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						CTGGCCTTTGGCTGGGTCTTT	0.453000													18	82					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102825195	102825195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102825195C>T	ENST00000260302.3	-	3	531	c.503G>A	c.(502-504)gGa>gAa	p.G168E	MMP13_ENST00000340273.4_Missense_Mutation_p.G168E	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	168					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		ACCCTTAATTCCAAAAGAGAT	0.303000													12	36					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240497465	240497465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240497465G>A	ENST00000319653.9	+	13	4931	c.4701G>A	c.(4699-4701)caG>caA	p.Q1567Q	FMN2_ENST00000545751.1_Silent_p.Q163Q	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1567	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ACCTTTTTCAGGCCTCACAGA	0.363000													79	202					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79350286	79350286	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79350286G>A	ENST00000233735.1	+	6	549	c.446G>A	c.(445-447)tGg>tAg	p.W149*		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	149	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						TTCCAGAAATGGAAGGATGTG	0.418000													23	39					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34263239	34263239	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:34263239C>T	ENST00000262622.3	+	4	1304	c.546C>T	c.(544-546)tcC>tcT	p.S182S	CHST8_ENST00000438847.2_Silent_p.S182S|CHST8_ENST00000434302.1_Silent_p.S182S	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	182					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					GCCACGTGTCCCGTATCTTCG	0.706000													6	47					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50090791	50090791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50090791C>T	ENST00000281631.5	+	12	1126	c.968C>T	c.(967-969)tCc>tTc	p.S323F	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505554.1_Missense_Mutation_p.S302F|PARP8_ENST00000503750.2_Missense_Mutation_p.S323F|PARP8_ENST00000514342.2_Missense_Mutation_p.S76F|PARP8_ENST00000505697.2_Missense_Mutation_p.S323F|PARP8_ENST00000514067.2_Missense_Mutation_p.S323F	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	323						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				AGGACTTGTTCCAGCACAGTC	0.527000													20	64					0	0	1	0	0
ZNF98	148198	broad.mit.edu	37	19	22574492	22574492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22574492C>T	ENST00000357774.5	-	4	1666	c.1545G>A	c.(1543-1545)gaG>gaA	p.E515E		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TGTAGGGTTTCTCTCCAGTAT	0.393000													23	77					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14801670	14801670	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14801670G>A	ENST00000380881.4	-	21	4492	c.3677C>T	c.(3676-3678)tCc>tTc	p.S1226F	FREM1_ENST00000380880.3_Missense_Mutation_p.S1225F|FREM1_ENST00000422223.2_Missense_Mutation_p.S1225F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1225					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GAGTTCCATGGAAAAGCTGTG	0.423000													11	25					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41758775	41758775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41758775G>A	ENST00000301178.4	+	16	2019	c.1829G>A	c.(1828-1830)cGa>cAa	p.R610Q	AXL_ENST00000359092.3_Missense_Mutation_p.R601Q|AXL_ENST00000593513.1_Missense_Mutation_p.R342Q	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	610	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GGTTCTGAACGAGAGAGCTTC	0.597000													21	92					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30864450	30864450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30864450C>T	ENST00000324771.8	+	15	2225	c.1677C>T	c.(1675-1677)ccC>ccT	p.P559P	DDR1_ENST00000418800.2_Silent_p.P522P|DDR1_ENST00000361741.4_Intron|DDR1_ENST00000376570.4_Silent_p.P522P|DDR1_ENST00000376569.3_Silent_p.P522P|DDR1_ENST00000376567.2_Silent_p.P522P|DDR1_ENST00000452441.1_Silent_p.P559P|DDR1_ENST00000376568.3_Silent_p.P559P|DDR1_ENST00000508312.1_Silent_p.P540P|DDR1_ENST00000454612.2_Silent_p.P522P|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000513240.1_Silent_p.P559P|DDR1_ENST00000376575.3_Silent_p.P559P			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	559	Gly/Pro-rich.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CGCTTCTGCCCCCACCTCCCC	0.632000													34	68					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	108518107	108518107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:108518107C>T	ENST00000375915.2	-	1	976	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	280						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						TCAAACTCTTCGTATTTCTCC	0.527000													41	82					0	0	1	0	0
IGLV3-16	28799	broad.mit.edu	37	22	23090244	23090244	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23090244C>T	ENST00000390311.2	+	0	221																											CAGGCCAGTTCCCTGTGCTGG	0.522000													8	83					0	0	1	0	0
ZNF577	84765	broad.mit.edu	37	19	52376092	52376092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52376092G>A	ENST00000420592.1	-	6	2307	c.974C>T	c.(973-975)tCa>tTa	p.S325L	ZNF577_ENST00000485702.1_Intron|ZNF577_ENST00000451628.2_Missense_Mutation_p.S325L|ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000301399.5_Missense_Mutation_p.S384L			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CACCGTCAGTGAATTTATGGC	0.423000													39	133					0	0	1	0	0
OR52E8	390079	broad.mit.edu	37	11	5878886	5878886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5878886G>A	ENST00000537935.1	-	1	78	c.47C>T	c.(46-48)tCt>tTt	p.S16F	TRIM5_ENST00000380027.1_Intron	NM_001005168.1	NP_001005168.1	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E, member 8	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGGAATGAAGAAGGATGGAA	0.433000													57	159					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413483	124413483	+	Missense_Mutation	SNP	C	C	T	rs140680123		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124413483C>T	ENST00000306842.2	-	1	92	c.68G>A	c.(67-69)cGg>cAg	p.R23Q		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		GAGGGGGATCCGCAGTCCCGG	0.547000													12	135					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123540242	123540242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:123540242C>T	ENST00000422452.2	-	26	5143	c.5080G>A	c.(5080-5082)Gat>Aat	p.D1694N	TENM1_ENST00000371130.3_Missense_Mutation_p.D1687N|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1									p.D1689H(1)									TTGGAAGTATCTAGCTCCACT	0.458000													40	81					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154147141	154147141	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:154147141G>A	ENST00000389740.2	-	1	363	c.264C>T	c.(262-264)ttC>ttT	p.F88F		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	88						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCAAAAACATGAAGATGGTCA	0.483000													21	129					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69050671	69050671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:69050671G>A	ENST00000288368.4	+	33	4283	c.4006G>A	c.(4006-4008)Gaa>Aaa	p.E1336K		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1336					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AGCCATGTTAGAAGATACACT	0.303000													8	107					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142561068	142561068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142561068C>T	ENST00000392957.2	+	5	870	c.83C>T	c.(82-84)tCa>tTa	p.S28L	EPHB6_ENST00000442129.1_Missense_Mutation_p.S28L|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	28						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CTGGTGTCTTCAGTTCTGGCT	0.557000													14	38					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11905848	11905848	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11905848C>T	ENST00000256720.2	+	2	274	c.181C>T	c.(181-183)Cga>Tga	p.R61*	LPIN1_ENST00000449576.2_Nonsense_Mutation_p.R110*|LPIN1_ENST00000396098.1_Nonsense_Mutation_p.R67*|LPIN1_ENST00000396099.1_Nonsense_Mutation_p.R67*|LPIN1_ENST00000425416.2_Nonsense_Mutation_p.R67*	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	61	N-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity	p.R61R(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CCTGCGCTCCCGAGAGAAAGT	0.577000													27	55					0	0	1	0	0
PRAMEF22	653606	broad.mit.edu	37	1	13036637	13036637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:13036637C>T	ENST00000376187.1	+	2	709	c.709C>T	c.(709-711)Cgc>Tgc	p.R237C	PRAMEF6_ENST00000376192.5_Intron	NM_001100631.1	NP_001094101.1	A3QJZ6	PRA22_HUMAN	PRAME family member 22	237										kidney(1)|large_intestine(2)|lung(1)|skin(1)	5						GAGGAATCTTCGCAAACTCTT	0.473000													79	220					0	0	1	0	0
SLC1A2	6506	broad.mit.edu	37	11	35336622	35336622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:35336622C>T	ENST00000278379.3	-	3	540	c.258G>A	c.(256-258)atG>atA	p.M86I	SLC1A2_ENST00000395750.1_Missense_Mutation_p.M77I|SLC1A2_ENST00000395753.1_Missense_Mutation_p.M77I|SLC1A2_ENST00000606205.1_Missense_Mutation_p.M86I	NM_004171.3	NP_004162.2	P43004	EAA2_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 2	86					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|urinary_tract(1)	24	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	TTAGCATCCTCATGAGTATAT	0.493000													37	42					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120582833	120582833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120582833G>A	ENST00000300648.6	-	40	5061	c.5049C>T	c.(5047-5049)gcC>gcT	p.A1683A		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1683				A -> V (in Ref. 7; AAC51648).	regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTTCACCATGGCCCCAAGGG	0.577000													27	77					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31585462	31585462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31585462C>T	ENST00000356173.3	-	6	464	c.372G>A	c.(370-372)tcG>tcA	p.S124S	SUN5_ENST00000375523.3_Silent_p.S99S	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	124					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						CTTTCATTTTCGATGGTAAGT	0.473000													22	39					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782274	54782274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54782274G>A	ENST00000391748.1	-	7	1225	c.1098C>T	c.(1096-1098)ctC>ctT	p.L366L	LILRB2_ENST00000391746.1_Silent_p.L366L|LILRB2_ENST00000314446.5_Silent_p.L366L|LILRB2_ENST00000434421.1_Silent_p.L250L|LILRB2_ENST00000391749.4_Silent_p.L366L	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	366	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ATCTTAGACGGAGTGGGGCAT	0.572000													55	154					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40719516	40719516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40719516C>T	ENST00000253055.3	+	9	2218	c.1930C>T	c.(1930-1932)Ccc>Tcc	p.P644S		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	644					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GCCTGCCGAGCCCTccccggg	0.761000													6	26					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080427	152080427	+	Missense_Mutation	SNP	G	G	A	rs71585886		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152080427G>A	ENST00000368804.1	-	2	5265	c.5266C>T	c.(5266-5268)Cgt>Tgt	p.R1756C		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1756	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTTCCGGACGGAGCTGCTCT	0.592000													16	118					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75408264	75408264	+	Silent	SNP	C	C	T	rs71471632		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75408264C>T	ENST00000394810.2	-	4	1295	c.1146G>A	c.(1144-1146)gaG>gaA	p.E382E	SYNPO2L_ENST00000372873.4_Silent_p.E158E|SYNPO2L_ENST00000372872.4_Silent_p.E382E	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	382						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					GCCCAGAGACCTCACTCAGCT	0.637000													26	74					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760539	54760539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54760539C>T	ENST00000450632.1	-	3	245	c.168G>A	c.(166-168)gaG>gaA	p.E56E	LILRB5_ENST00000449561.2_Silent_p.E56E|LILRB5_ENST00000316219.5_Silent_p.E56E|LILRB5_ENST00000345866.6_Silent_p.E56E			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	56	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACGGTACTCCTCAGTCTCCA	0.627000													58	117					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98312041	98312041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98312041G>A	ENST00000264193.2	-	1	526	c.308C>T	c.(307-309)cCt>cTt	p.P103L		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	103						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CGAGGTCTTAGGCAACATCTC	0.741000													6	12					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913368	6913368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6913368G>A	ENST00000299459.2	-	1	462	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCAACATAGCGATCATAGGAC	0.483000													51	32					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103137058	103137058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103137058C>T	ENST00000428762.1	-	56	9267	c.9108G>A	c.(9106-9108)gtG>gtA	p.V3036V	RELN_ENST00000424685.2_Silent_p.V3036V|RELN_ENST00000343529.5_Silent_p.V3036V|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3036					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAGCACGCTCCACCCCAGAGA	0.483000													20	72					0	0	1	0	0
USP30	84749	broad.mit.edu	37	12	109511303	109511303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109511303C>T	ENST00000257548.5	+	7	779	c.686C>T	c.(685-687)aCt>aTt	p.T229I	USP30_ENST00000392784.2_Missense_Mutation_p.T198I	NM_032663.3	NP_116052.2	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	229					ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(7)|kidney(1)|large_intestine(1)|liver(2)|lung(11)|prostate(1)|skin(3)|stomach(2)	28						GGAAGACTCACTAGTAATATG	0.403000													13	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9002672	9002672	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9002672G>A	ENST00000397910.4	-	51	40347	c.40142_splice	c.e51-1	p.P13382_splice	MUC16_ENST00000380951.5_Splice_Site_p.P23_splice	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13384	SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCTTCTCAGGCCTAGGGAGG	0.547000													18	60					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46501502	46501502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46501502C>T	ENST00000361297.2	+	29	5444	c.5161C>T	c.(5161-5163)Ccc>Tcc	p.P1721S	MAST2_ENST00000372008.1_Intron|MAST2_ENST00000372009.2_Missense_Mutation_p.P1531S	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1721					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					TTATGAGGATCCCAGCCAGGG	0.577000													5	68					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237538048	237538048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237538048C>T	ENST00000366574.2	+	7	733	c.416C>T	c.(415-417)tCa>tTa	p.S139L	RYR2_ENST00000542537.1_Missense_Mutation_p.S123L|RYR2_ENST00000360064.6_Missense_Mutation_p.S137L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	139	MIR 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCCCGGTCTTCAACTGATAAG	0.478000													6	10					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152557374	152557374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152557374C>T	ENST00000367255.5	-	110	20865	c.20264G>A	c.(20263-20265)cGa>cAa	p.R6755Q	SYNE1_ENST00000448038.1_Missense_Mutation_p.R6684Q|SYNE1_ENST00000423061.1_Missense_Mutation_p.R6684Q|SYNE1_ENST00000265368.4_Missense_Mutation_p.R6755Q|SYNE1_ENST00000341594.5_Missense_Mutation_p.R6367Q|SYNE1_ENST00000356820.4_Missense_Mutation_p.R1279Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6755					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TATCAGAAGTCGTTTCCCATC	0.338000										HNSCC(10;0.0054)			30	32					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935936	30935936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30935936G>A	ENST00000355537.3	+	2	1614	c.1467G>A	c.(1465-1467)ctG>ctA	p.L489L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.L489L(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ACTCCCTCCTGGGATGCCTCA	0.657000													26	54					0	0	1	0	0
PDHA2	5161	broad.mit.edu	37	4	96761857	96761857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:96761857G>A	ENST00000295266.4	+	1	619	c.556G>A	c.(556-558)Gag>Aag	p.E186K		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	186					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	AGGAAACGATGAGATCTGTTT	0.478000													33	82					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8486138	8486138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8486138G>A	ENST00000381196.4	-	25	3222	c.2679C>T	c.(2677-2679)ttC>ttT	p.F893F	PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Silent_p.F893F|PTPRD_ENST00000360074.4_Silent_p.F880F|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Silent_p.F871F|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Silent_p.F893F|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000397606.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	893	Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTGAGAGCCTGAAGACGTATG	0.463000										TSP Lung(15;0.13)			27	34					0	0	1	0	0
MAML1	9794	broad.mit.edu	37	5	179193008	179193008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179193008C>T	ENST00000292599.3	+	2	1260	c.997C>T	c.(997-999)Cct>Tct	p.P333S	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	333					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCTCTGCCCCTGTGAGTAC	0.602000													20	41					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15770051	15770051	+	Silent	SNP	C	C	T	rs140820169	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15770051C>T	ENST00000221307.7	+	13	1467	c.1419C>T	c.(1417-1419)ttC>ttT	p.F473F	CYP4F3_ENST00000586182.1_Silent_p.F473F|CYP4F3_ENST00000585846.1_Silent_p.F473F|CYP4F3_ENST00000591058.1_Silent_p.F473F	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	473					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GGCAGGCGTTCGCGATGGCGG	0.672000													19	25					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196913028	196913028	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196913028T>C	ENST00000312428.6	-	4	342	c.242A>G	c.(241-243)cAg>cGg	p.Q81R	DNAH7_ENST00000410072.1_Missense_Mutation_p.Q81R	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	81	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACCATGGGACTGTTCATTTTT	0.363000													24	75					0	0	1	0	0
SLC2A1	6513	broad.mit.edu	37	1	43394917	43394917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43394917G>A	ENST00000426263.3	-	7	1114	c.936C>T	c.(934-936)ggC>ggT	p.G312G	SLC2A1_ENST00000475162.1_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1	312					carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CGATACCGGAGCCAATGGTGG	0.587000													7	29					0	0	1	0	0
TFE3	7030	broad.mit.edu	37	X	48896732	48896732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48896732G>A	ENST00000315869.7	-	3	693	c.434C>T	c.(433-435)cCt>cTt	p.P145L	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	145					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						GGCAGGTGCAGGACTGGGGAA	0.682000			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								13	14					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153913883	153913883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153913883G>A	ENST00000361217.4	-	7	1507	c.1089C>T	c.(1087-1089)ttC>ttT	p.F363F		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	363	DENN.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTGGGGAAGGGAAGGGAACGT	0.592000													10	29					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117665424	117665424	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117665424C>T	ENST00000317775.6	-	23	4113	c.3428G>A	c.(3427-3429)tGg>tAg	p.W1143*	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Nonsense_Mutation_p.W1177*	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1143	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GCCCCATTTCCATTCCTCGTA	0.592000													17	58					0	0	1	0	0
TSPY1	7258	broad.mit.edu	37	Y	9305956	9305956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:9305956C>T	ENST00000451548.1	+	3	658	c.612C>T	c.(610-612)ttC>ttT	p.F204F	TSPY3_ENST00000440483.1_Intron|TSPY1_ENST00000423647.2_Silent_p.F210F|AC006156.1_ENST00000423213.1_Intron|AC006156.1_ENST00000450145.1_Intron	NM_001197242.1|NM_003308.3	NP_001184171.1|NP_003299.2	Q01534	TSPY1_HUMAN	testis specific protein, Y-linked 1	204					cell differentiation|cell proliferation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus	identical protein binding			lung(4)	4						TCATGTTGTTCTTTCGGAGTA	0.478000													47	272					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188492	57188492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57188492C>T	ENST00000331162.4	-	5	900	c.630G>A	c.(628-630)gaG>gaA	p.E210E		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TGTAGGACTTCTCCCTAGTAT	0.333000													10	32					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610225	47610225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47610225G>A	ENST00000371891.3	+	8	932	c.901G>A	c.(901-903)Gag>Aag	p.E301K	CYP4A22_ENST00000371890.3_Intron|CYP4A22_ENST00000294337.3_Missense_Mutation_p.E301K|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000485117.1_Intron	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	301						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTCCCAGATGGAGAATGGGAG	0.537000													31	154					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597494	136597494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136597494C>T	ENST00000531224.1	-	5	1421	c.1169G>A	c.(1168-1170)gGa>gAa	p.G390E	BCLAF1_ENST00000527536.1_Missense_Mutation_p.G390E|BCLAF1_ENST00000527759.1_Missense_Mutation_p.G388E|BCLAF1_ENST00000392348.2_Missense_Mutation_p.G388E|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000353331.4_Missense_Mutation_p.G388E	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	390					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTTTTGTTTTCCAGACTCTTT	0.423000													56	560					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640205	34640205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34640205C>T	ENST00000537011.1	+	3	518	c.136C>T	c.(136-138)Cct>Tct	p.P46S	NUTM1_ENST00000333756.4_Missense_Mutation_p.P18S|NUTM1_ENST00000438749.3_Missense_Mutation_p.P36S					NUT midline carcinoma, family member 1																		GAGCATGAAACCTAGTGCCGC	0.532000													13	69					0	0	1	0	0
SCRN1	9805	broad.mit.edu	37	7	29976195	29976195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:29976195G>A	ENST00000426154.1	-	6	1058	c.882C>T	c.(880-882)ttC>ttT	p.F294F	SCRN1_ENST00000416113.2_Silent_p.F120F|SCRN1_ENST00000242059.5_Silent_p.F294F|SCRN1_ENST00000409497.1_Silent_p.F294F	NM_001145513.1	NP_001138985.1	Q12765	SCRN1_HUMAN	secernin 1	294					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(2)|prostate(2)|skin(2)	25						GGGTTCCAGTGAAGTAGTGAA	0.522000													37	149					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57597283	57597283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57597283G>A	ENST00000243077.3	+	70	11396	c.10930G>A	c.(10930-10932)Gag>Aag	p.E3644K		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3644	LDL-receptor class A 28.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CGGCAGCGACGAGGAGGCCTG	0.677000													4	7					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046936	42046936	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42046936A>T	ENST00000372584.1	-	3	4547	c.3533T>A	c.(3532-3534)aTg>aAg	p.M1178K	HIVEP3_ENST00000429157.2_Missense_Mutation_p.M1178K|HIVEP3_ENST00000372583.1_Missense_Mutation_p.M1178K|HIVEP3_ENST00000247584.5_Missense_Mutation_p.M1178K	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1178					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AAGTGGGGGCATGGAGTATGG	0.577000													38	127					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991276	70991276	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70991276A>G	ENST00000256389.3	-	2	593	c.349T>C	c.(349-351)Ttt>Ctt	p.F117L	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	67					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TGTCCCCCAAACCGCAGGCTA	0.522000													29	77					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189923576	189923576	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189923576C>T	ENST00000374866.3	-	32	2403	c.2130_splice	c.e32+1	p.R710_splice		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	710					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent	p.R710I(1)		NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AATACTTACTCTAGGTCCTAA	0.343000													10	35					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45410157	45410157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45410157G>A	ENST00000332700.6	-	4	1103	c.932C>T	c.(931-933)cCc>cTc	p.P311L		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	311						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		TGCTTCTGGGGGTGGTGCCCC	0.483000													27	57					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995378	140995378	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140995378C>T	ENST00000285879.4	+	4	2474	c.2188C>T	c.(2188-2190)Cct>Tct	p.P730S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	730							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGTTTCCTCCTCAGGG	0.547000										HNSCC(15;0.026)			65	71					0	0	1	0	0
PSAT1	29968	broad.mit.edu	37	9	80943007	80943007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:80943007C>T	ENST00000376588.3	+	8	978	c.910C>T	c.(910-912)Cca>Tca	p.P304S	PSAT1_ENST00000347159.2_Intron	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	304					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	GATGAATATTCCATTCCGCAT	0.368000													12	39					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230326	140230326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140230326C>T	ENST00000378122.3	+	1	2970	c.2246C>T	c.(2245-2247)tCg>tTg	p.S749L	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.S749L|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAGTTGGTCGTACTCGCAG	0.647000													43	36					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30749771	30749771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30749771C>T	ENST00000262518.4	+	34	8795	c.8410C>T	c.(8410-8412)Ccc>Tcc	p.P2804S	SRCAP_ENST00000344771.4_Missense_Mutation_p.P2646S|SRCAP_ENST00000395059.2_Missense_Mutation_p.P2742S	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2804	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			ATCCTCCCCTCCCATTGGTGG	0.647000													7	102					0	0	1	0	0
CLASRP	11129	broad.mit.edu	37	19	45563679	45563679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45563679C>T	ENST00000544944.2	+	8	1435	c.743C>T	c.(742-744)gCc>gTc	p.A248V	CLASRP_ENST00000221455.3_Missense_Mutation_p.A248V|CLASRP_ENST00000391953.4_Missense_Mutation_p.A186V			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	248					mRNA processing|RNA splicing	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						GAGGCAGAGGCCATCAAGCAT	0.592000													22	65					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16504332	16504332	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:16504332C>T	ENST00000304523.5	-	8	1379	c.1056G>A	c.(1054-1056)tgG>tgA	p.W352*	LDB2_ENST00000441778.2_3'UTR|LDB2_ENST00000502640.1_3'UTR|RP11-446J8.1_ENST00000512370.1_RNA|LDB2_ENST00000515064.1_Nonsense_Mutation_p.W350*	NM_001290.3	NP_001281.1	O43679	LDB2_HUMAN	LIM domain binding 2	352							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						GTTTACTGTTCCACGGGCTGT	0.522000													56	160					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37709508	37709508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37709508G>A	ENST00000248901.6	+	13	1328	c.1141G>A	c.(1141-1143)Gac>Aac	p.D381N		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	381					regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CCCCTTCTACGACCTGGTCTC	0.587000													13	91					0	0	1	0	0
APOBEC2	10930	broad.mit.edu	37	6	41029269	41029269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41029269G>A	ENST00000244669.2	+	2	378	c.334G>A	c.(334-336)Gac>Aac	p.D112N		NM_006789.3	NP_006780.1	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	112					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding	p.D112N(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)	10	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCCAGCCTTCGACCCAGCCCT	0.572000													60	166					0	0	1	0	0
DKK4	27121	broad.mit.edu	37	8	42233236	42233236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42233236C>T	ENST00000220812.2	-	2	410	c.224G>A	c.(223-225)cGa>cAa	p.R75Q		NM_014420.2	NP_055235.1	Q9UBT3	DKK4_HUMAN	dickkopf WNT signaling pathway inhibitor 4	75	DKK-type Cys-1.				multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region		p.R75Q(1)		NS(1)|endometrium(1)|large_intestine(7)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			CATGGCATCTCGCTGGCACCT	0.552000													11	62					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89391132	89391132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:89391132C>T	ENST00000336596.2	+	5	1423	c.1198C>T	c.(1198-1200)Ctg>Ttg	p.L400L	EPHA3_ENST00000494014.1_Silent_p.L400L|EPHA3_ENST00000452448.2_Silent_p.L400L	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	400	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GACAGACCTTCTGGCACATAC	0.507000										TSP Lung(6;0.00050)			26	54					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175764149	175764149	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:175764149G>A	ENST00000443967.1	+	11	2763	c.2356_splice	c.e11+1	p.E786_splice	SIMC1_ENST00000332772.4_Splice_Site_p.E247_splice|SIMC1_ENST00000341199.6_Splice_Site_p.E371_splice|SIMC1_ENST00000430704.2_Splice_Site_p.E371_splice					SUMO-interacting motifs containing 1																		TGTTTTAAGAGGTAAGGAGCA	0.403000													24	112					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165791	172165791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172165791C>T	ENST00000241256.2	-	1	455	c.413G>A	c.(412-414)aGc>aAc	p.S138N	GHSR_ENST00000427970.1_Missense_Mutation_p.S138N	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	138					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GCGCTCGACGCTCAGCGCTGT	0.622000													8	28					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628883	3628883	+	Missense_Mutation	SNP	C	C	T	rs150287837		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3628883C>T	ENST00000325418.4	+	1	1673	c.1654C>T	c.(1654-1656)Cgc>Tgc	p.R552C	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	552	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										AGTGTGCAACCGCACAGAAGG	0.478000													33	34					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327285	52327285	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52327285C>T	ENST00000339223.4	+	2	463	c.284C>T	c.(283-285)tCa>tTa	p.S95L	FPR3_ENST00000595991.1_Missense_Mutation_p.S95L	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	95					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						CCTTTTGGCTCATTCCTATGT	0.453000													38	93					0	0	1	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117774392	117774392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117774392G>A	ENST00000528626.1	-	11	1623	c.1550C>T	c.(1549-1551)cCc>cTc	p.P517L	TMPRSS13_ENST00000524993.1_Missense_Mutation_p.P552L|TMPRSS13_ENST00000430170.2_Missense_Mutation_p.P552L|TMPRSS13_ENST00000445164.2_Missense_Mutation_p.P552L	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	547	Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GTAAATCCAGGGAAGAACTTC	0.577000													14	28					0	0	1	0	0
CES3	23491	broad.mit.edu	37	16	66998585	66998585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66998585C>T	ENST00000303334.4	+	6	845	c.774C>T	c.(772-774)atC>atT	p.I258I	CES3_ENST00000394037.1_Silent_p.I258I	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	258						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GTGGGGTCATCACCACCCCAG	0.587000													28	96					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436697	248436697	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248436697C>T	ENST00000318021.2	-	1	441	c.420G>A	c.(418-420)ctG>ctA	p.L140L		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGTCATCCTCAGGCACAGCT	0.582000													32	167					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227907816	227907816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227907816G>A	ENST00000396625.3	-	36	3581	c.3374C>T	c.(3373-3375)tCc>tTc	p.S1125F	COL4A4_ENST00000329662.7_Missense_Mutation_p.S1125F	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1125	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGGTCCAGAGGAGCCAGGTGG	0.532000													22	44					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105353296	105353296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105353296C>T	ENST00000453495.1	+	12	2951	c.2723C>T	c.(2722-2724)tCc>tTc	p.S908F	CEP170B_ENST00000414716.3_Missense_Mutation_p.S907F|CEP170B_ENST00000556508.1_Missense_Mutation_p.S837F|CEP170B_ENST00000418279.1_Missense_Mutation_p.S837F					centrosomal protein 170B																		GACTTCCACTCCCAGGACACC	0.682000													20	58					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6083359	6083359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6083359G>A	ENST00000409021.3	-	6	1527	c.1078C>T	c.(1078-1080)Ctc>Ttc	p.L360F	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.L195F|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.L360F|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.L195F|JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.L360F	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	360	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding	p.L360I(2)		NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCCCGCGTGAGGTTCTTGATT	0.532000													26	80					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435835	158435835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158435835C>T	ENST00000289451.2	+	1	564	c.484C>T	c.(484-486)Cta>Tta	p.L162L		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					CACCACCTCCCTAGTATTTCA	0.557000													75	199					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76980019	76980019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76980019C>T	ENST00000315938.4	-	8	824	c.574G>A	c.(574-576)Gag>Aag	p.E192K	GDPD4_ENST00000376217.2_Missense_Mutation_p.E192K	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	192					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						CCCAAATTCTCCTTCTCCTGA	0.453000													42	126					0	0	1	0	0
ABCA11P	79963	broad.mit.edu	37	4	419584	419584	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:419584G>A	ENST00000451020.2	-	0	1454					NR_002451.2																						AGTTTCCATCGAACTGTTATA	0.393000													8	31					0	0	1	0	0
U2SURP	23350	broad.mit.edu	37	3	142741799	142741799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142741799C>T	ENST00000473835.2	+	12	1213	c.1123C>T	c.(1123-1125)Ccc>Tcc	p.P375S	U2SURP_ENST00000397933.2_5'UTR|U2SURP_ENST00000493598.2_Missense_Mutation_p.P374S	NM_001080415.1	NP_001073884.1	O15042	SR140_HUMAN	U2 snRNP-associated SURP domain containing	375	Pro-rich.				RNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	31						ACATACGCTTCCCCCACCTCC	0.433000													4	24					0	0	1	0	0
DPYSL3	1809	broad.mit.edu	37	5	146777300	146777300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:146777300C>T	ENST00000343218.5	-	12	1929	c.1732G>A	c.(1732-1734)Ggg>Agg	p.G578R	DPYSL3_ENST00000534907.1_Missense_Mutation_p.G90R|DPYSL3_ENST00000398514.3_Missense_Mutation_p.G464R	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	464					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCCAGCCCCCTGGGTCACG	0.562000													31	94					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49137072	49137072	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49137072G>A	ENST00000306125.6	-	16	1734	c.1397C>T	c.(1396-1398)tCc>tTc	p.S466F	QARS_ENST00000414533.1_Missense_Mutation_p.S455F			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	466					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	CCAGAAGTAGGAAGAGCGTCT	0.567000													5	56					0	0	1	0	0
OR4C11	219429	broad.mit.edu	37	11	55371562	55371562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55371562C>T	ENST00000302231.4	-	1	312	c.288G>A	c.(286-288)atG>atA	p.M96I		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						AGACTTGTGTCATGCACTCAT	0.413000													53	101					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585343	7585343	+	Silent	SNP	G	G	A	rs148798300		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7585343G>A	ENST00000379802.3	+	24	8189	c.7848G>A	c.(7846-7848)tcG>tcA	p.S2616S	DSP_ENST00000418664.2_Silent_p.S2017S	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2616	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGGAAGAATCGAGCCCCATTG	0.483000													46	94					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170222320	170222320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:170222320G>A	ENST00000518525.1	+	6	813	c.349G>A	c.(349-351)Gtg>Atg	p.V117M	GABRP_ENST00000519385.1_Missense_Mutation_p.V117M|GABRP_ENST00000265294.4_Missense_Mutation_p.V117M|GABRP_ENST00000519598.1_Missense_Mutation_p.V117M			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	117						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GTTCCTCTGGGTGCCAGATAC	0.552000													55	130					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510452	56510452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56510452G>A	ENST00000302957.3	-	1	835	c.836C>T	c.(835-837)tCc>tTc	p.S279F		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGAGTAGGTGGAACTAGGCCT	0.468000													36	85					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813752	123813752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123813752G>A	ENST00000321252.2	-	1	828	c.794C>T	c.(793-795)gCt>gTt	p.A265V		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TTTGGACTGAGCCTCTGACAT	0.507000													43	139					0	0	1	0	0
LHX6	26468	broad.mit.edu	37	9	124979518	124979518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:124979518C>T	ENST00000394319.4	-	5	615	c.511G>A	c.(511-513)Gac>Aac	p.D171N	LHX6_ENST00000373754.2_Missense_Mutation_p.D142N|LHX6_ENST00000559895.1_5'UTR|LHX6_ENST00000541397.2_Missense_Mutation_p.D160N|LHX6_ENST00000373755.2_Missense_Mutation_p.D142N|LHX6_ENST00000340587.3_Missense_Mutation_p.D171N	NM_014368.4	NP_055183.2	Q9UPM6	LHX6_HUMAN	LIM homeobox 6	142	LIM zinc-binding 2.|Required for interaction with LBD1 (By similarity).				cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)	8						CGCACCCAGTCGCTGGCGTAG	0.662000													19	24					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81698074	81698074	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:81698074G>A	ENST00000429644.2	-	5	1267	c.624C>T	c.(622-624)tcC>tcT	p.S208S	GBE1_ENST00000489715.1_Silent_p.S167S	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	208					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TTCCTTCATGGGAAGAAATTC	0.318000									Glycogen Storage Disease, type IV				9	18					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052304	15052304	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15052304G>A	ENST00000248072.3	+	1	4	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					CGGCCCCATGGAAAGAGGAAA	0.468000													51	146					0	0	1	0	0
ISX	91464	broad.mit.edu	37	22	35478634	35478634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:35478634G>A	ENST00000308700.6	+	2	1305	c.353G>A	c.(352-354)aGg>aAg	p.R118K	ISX_ENST00000404699.2_Missense_Mutation_p.R118K	NM_001008494.1	NP_001008494.1	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	118						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(12)|ovary(3)|prostate(1)|skin(4)	26						CTGGCAGCCAGGATCAACCTC	0.572000													17	59					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53766094	53766094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53766094C>T	ENST00000288139.3	+	19	2636	c.2518C>T	c.(2518-2520)Cct>Tct	p.P840S	CACNA1D_ENST00000422281.2_Missense_Mutation_p.P820S|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P820S	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	820					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CCCCTATCCGCCTTGCGATGT	0.537000													7	68					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52603784	52603784	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52603784G>A	ENST00000395489.2	-	6	573	c.177C>T	c.(175-177)gaC>gaT	p.D59D	A1CF_ENST00000395495.1_Silent_p.D66D|A1CF_ENST00000373993.1_Silent_p.D66D|A1CF_ENST00000374001.1_Silent_p.D66D|A1CF_ENST00000373995.3_Silent_p.D74D|A1CF_ENST00000373997.3_Silent_p.D66D|A1CF_ENST00000282641.2_Silent_p.D66D	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	66	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CCTCAAAAAGGTCTCGGGGAA	0.393000													46	155					0	0	1	0	0
SH3RF1	57630	broad.mit.edu	37	4	170028273	170028273	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:170028273G>A	ENST00000284637.9	-	11	2564	c.2223C>T	c.(2221-2223)acC>acT	p.T741T		NM_020870.3	NP_065921.2	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	741						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CCACTTCTAGGGTGGGCGATG	0.577000													15	45					0	0	1	0	0
INO80C	125476	broad.mit.edu	37	18	33060487	33060487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:33060487G>A	ENST00000592173.1	-	2	255	c.197C>T	c.(196-198)cCc>cTc	p.P66L	INO80C_ENST00000334598.7_Missense_Mutation_p.P66L|INO80C_ENST00000441607.2_Missense_Mutation_p.P102L|RP11-322E11.6_ENST00000589258.1_Intron|INO80C_ENST00000586489.1_Missense_Mutation_p.P11L|INO80C_ENST00000590757.1_Intron			Q6PI98	IN80C_HUMAN	INO80 complex subunit C	66					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|MLL1 complex				central_nervous_system(1)|endometrium(1)|lung(3)|prostate(2)|skin(1)	8						AAACTCAGAGGGCACCATTTT	0.408000													17	152					0	0	1	0	0
CHST12	55501	broad.mit.edu	37	7	2472296	2472296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2472296C>T	ENST00000258711.6	+	2	157	c.22C>T	c.(22-24)Cgg>Tgg	p.R8W		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	8					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CCGGCTGTTCCGGCTGTGGCT	0.657000													17	35					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18776967	18776967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18776967G>A	ENST00000380548.4	+	19	3079	c.2740G>A	c.(2740-2742)Gac>Aac	p.D914N		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	914	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CTGGGAGAAGGACGGCCAGCA	0.677000													6	47					0	0	1	0	0
RFX5	5993	broad.mit.edu	37	1	151315436	151315436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151315436G>A	ENST00000290524.4	-	11	1255	c.1077C>T	c.(1075-1077)gcC>gcT	p.A359A	RFX5_ENST00000452513.2_Silent_p.A319A|RFX5_ENST00000452671.2_Silent_p.A359A|RFX5_ENST00000368870.2_Silent_p.A359A	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	359						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCACTTTCAGGGCACCTGAAG	0.592000													37	73					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101198189	101198189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:101198189G>A	ENST00000294728.2	+	7	1842	c.1741G>A	c.(1741-1743)Gga>Aga	p.G581R	VCAM1_ENST00000347652.2_Missense_Mutation_p.G489R|VCAM1_ENST00000370115.1_Missense_Mutation_p.G382R|VCAM1_ENST00000370119.4_Missense_Mutation_p.G519R	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	581	Ig-like C2-type 6.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	TTTATGTGAAGGAATTAACCA	0.413000													55	137					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455470	84455470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:84455470G>A	ENST00000377084.2	-	1	1058	c.173C>T	c.(172-174)tCc>tTc	p.S58F		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	58						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GTAAAACTGGGAAGTCGGGGC	0.433000													17	78					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34241243	34241243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34241243G>A	ENST00000374114.3	-	3	2265	c.2002C>T	c.(2002-2004)Ccc>Tcc	p.P668S	RBM12_ENST00000359646.1_Missense_Mutation_p.P668S|CPNE1_ENST00000397443.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.P668S|CPNE1_ENST00000397445.1_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000317677.5_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	668	Gly-rich.|Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CCTGCACCGGGAAGTCCTGCA	0.587000													21	39					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724971	49724971	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49724971C>A	ENST00000551245.1	+	13	2454	c.2343C>A	c.(2341-2343)ctC>ctA	p.L781L	TROAP_ENST00000257909.3_Intron|TROAP_ENST00000547923.1_Intron			Q12815	TROAP_HUMAN	trophinin associated protein	0					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						CCCCAGACCTCCCTCTAAATT	0.587000													11	27					4.68919e-08	4.70386e-08	1	1	0
NOXRED1	122945	broad.mit.edu	37	14	77861022	77861022	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77861022G>A	ENST00000380835.2	-	6	1198	c.1032C>T	c.(1030-1032)tcC>tcT	p.S344S		NM_001113475.2	NP_001106946.1	Q6NXP6	CN148_HUMAN	NADP-dependent oxidoreductase domain containing 1	344					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						CTTTGGTTAGGGAGATGCCAA	0.443000													30	58					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22941645	22941645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22941645G>A	ENST00000397104.3	-	5	792	c.793C>T	c.(793-795)Ctt>Ttt	p.L265F	ZNF99_ENST00000596209.1_Missense_Mutation_p.L356F					zinc finger protein 99									p.L265I(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTTTTCTAAGGGTTGAGGAC	0.368000													37	95					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900098	151900098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151900098C>T	ENST00000393900.3	-	3	1056	c.703G>A	c.(703-705)Gag>Aag	p.E235K	MAGEA12_ENST00000357916.4_Missense_Mutation_p.E235K|MAGEA12_ENST00000393869.3_Missense_Mutation_p.E235K|CSAG4_ENST00000361201.4_RNA	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	235	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					ACACTGTCCTCCCTCCCATCA	0.562000													86	69					0	0	1	0	0
PFKFB4	5210	broad.mit.edu	37	3	48587373	48587373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48587373G>A	ENST00000232375.3	-	3	347	c.235C>T	c.(235-237)Cgc>Tgc	p.R79C	PFKFB4_ENST00000490115.1_5'UTR|PFKFB4_ENST00000416568.1_Missense_Mutation_p.R79C|PFKFB4_ENST00000536104.1_Missense_Mutation_p.R68C|PFKFB4_ENST00000545984.1_Missense_Mutation_p.R79C|PFKFB4_ENST00000383734.2_Missense_Mutation_p.R79C|PFKFB4_ENST00000541519.1_Missense_Mutation_p.R45C	NM_004567.2	NP_004558.1	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	79	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ACGTCCCGGCGATACTGGCCA	0.502000													25	59					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207767	58207767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58207767G>A	ENST00000377918.3	+	1	1113	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	363	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GGCGCTGAGCGAGGCCGCCCC	0.672000													21	52					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105404490	105404490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105404490G>A	ENST00000333244.5	-	7	17417	c.17298C>T	c.(17296-17298)tcC>tcT	p.S5766S	AHNAK2_ENST00000557457.1_Silent_p.S764S	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5766						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTCTTGCCGCGGATGTCACCA	0.542000													21	38					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158284011	158284011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:158284011G>A	ENST00000296526.7	+	15	2792	c.2467G>A	c.(2467-2469)Ggc>Agc	p.G823S	GRIA2_ENST00000507898.1_Missense_Mutation_p.G776S|GRIA2_ENST00000449365.1_Missense_Mutation_p.G776S|GRIA2_ENST00000264426.9_Missense_Mutation_p.G823S|GRIA2_ENST00000393815.2_Missense_Mutation_p.G776S	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	823					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CCTTGTCGGGGGCCTTGGTTT	0.453000													15	99					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44223502	44223502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44223502C>T	ENST00000249130.5	-	7	896	c.761G>A	c.(760-762)cGg>cAg	p.R254Q	SULT4A1_ENST00000330884.4_Intron|SULT4A1_ENST00000540422.1_Intron			Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	254					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GAAGATCTTCCGAGCAAAGAC	0.403000													6	32					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150840204	150840204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150840204C>T	ENST00000370357.4	+	13	1635	c.1390C>T	c.(1390-1392)Ctc>Ttc	p.L464F		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	464						nucleus	signal transducer activity	p.L464V(4)|p.L464F(2)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					ATCCAACTCTCTCAAAAACAC	0.463000													28	27					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	11905494	11905494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11905494C>T	ENST00000396373.4	+	2	418	c.144C>T	c.(142-144)atC>atT	p.I48I	ETV6_ENST00000544715.1_3'UTR	NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	48	PNT.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				AAGACTCGATCCGCCTGCCTG	0.622000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								22	56					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112167654	112167654	+	Nonsense_Mutation	SNP	C	C	T	rs146335507		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:112167654C>T	ENST00000455480.2	+	11	1558	c.1381C>T	c.(1381-1383)Cga>Tga	p.R461*	ACAD10_ENST00000549590.1_Nonsense_Mutation_p.R430*|ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000313698.4_Nonsense_Mutation_p.R430*|ACAD10_ENST00000392636.2_Nonsense_Mutation_p.R32*	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	430							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						TAAGCAGTATCGAGCTTCCGA	0.542000													16	55					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21805064	21805064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21805064C>T	ENST00000328843.6	+	56	9011	c.8980C>T	c.(8980-8982)Cca>Tca	p.P2994S	DNAH11_ENST00000409508.3_Missense_Mutation_p.P2987S			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2994	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GTGTTTCTCTCCAGTTGGTCG	0.502000									Kartagener syndrome				49	106					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192544995	192544995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:192544995G>A	ENST00000367459.3	+	1	139	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	RGS1_ENST00000469578.2_Missense_Mutation_p.E25K	NM_002922.3	NP_002913.3	Q08116	RGS1_HUMAN	regulator of G-protein signaling 1	25					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			kidney(8)|large_intestine(1)|lung(13)	22		Breast(1374;0.188)				TAACCCAAAGGAATTGAAAGG	0.418000													23	50					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269982	150269982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150269982G>A	ENST00000255945.2	+	3	999	c.824G>A	c.(823-825)aGa>aAa	p.R275K	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Missense_Mutation_p.R289K	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	275							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGGAAAAGAGAAAGAAGCAA	0.463000													20	49					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61413644	61413644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61413644G>A	ENST00000395348.3	-	5	1776	c.1140C>T	c.(1138-1140)atC>atT	p.I380I	SLC16A9_ENST00000395347.1_Silent_p.I380I	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	380					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						GGCCCATGATGATTAAGGTAG	0.418000													42	82					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111090583	111090583	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:111090583T>G	ENST00000262839.2	-	6	2377	c.1459A>C	c.(1459-1461)Att>Ctt	p.I487L		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	487					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GAACTTAAAATGTTGGATATT	0.463000													20	28					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17468993	17468993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17468993G>A	ENST00000400588.1	-	3	650	c.543C>T	c.(541-543)tgC>tgT	p.C181C	GAB4_ENST00000523144.1_Intron	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	181										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCTGATGGGAGCAGCTGGGCT	0.607000													13	21					0	0	1	0	0
IGHV3-73	28409	broad.mit.edu	37	14	107211030	107211030	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107211030C>T	ENST00000390636.2	-	0	338																											GTGAACCTGCCTTTCACCGAC	0.527000													40	123					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57425699	57425699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57425699C>T	ENST00000543257.1	-	3	653	c.87G>A	c.(85-87)aaG>aaA	p.K29K	C8B_ENST00000371237.4_Silent_p.K81K|C8B_ENST00000535057.1_5'UTR	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	81					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TTACCCTTTTCTTCTGACAGG	0.532000													15	29					0	0	1	0	0
FNDC5	252995	broad.mit.edu	37	1	33333418	33333418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33333418C>T	ENST00000373471.3	-	4	501	c.210G>A	c.(208-210)ggG>ggA	p.G70G		NM_001171940.1|NM_153756.2	NP_001165411.1|NP_715637.1	Q8NAU1	FNDC5_HUMAN	fibronectin type III domain containing 5	129	Fibronectin type-III.					integral to membrane|peroxisomal membrane				breast(1)|large_intestine(1)|lung(2)|ovary(1)	5		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GTTGGTTCCTCCCCATCTCTT	0.567000													15	57					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128178990	128178990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128178990G>A	ENST00000453608.2	+	3	273	c.265G>A	c.(265-267)Gag>Aag	p.E89K	PROC_ENST00000409048.1_Missense_Mutation_p.E68K|PROC_ENST00000422777.3_Missense_Mutation_p.E68K|PROC_ENST00000234071.3_Missense_Mutation_p.E68K			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	68			G -> C (in patients with PROC deficiency).		blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	TGACTTCGAGGAGGCCAAGGA	0.587000													17	40					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43947855	43947855	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43947855G>A	ENST00000282406.4	+	16	2618	c.2508G>A	c.(2506-2508)aaG>aaA	p.K836K		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	836	PH 2.					cytoplasm|cytoskeleton|integral to membrane	binding	p.K836N(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TAATAGGAAAGACATTATATT	0.323000													59	152					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73484039	73484039	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73484039C>T	ENST00000314256.7	+	6	830	c.436C>T	c.(436-438)Cag>Tag	p.Q146*	KIAA0195_ENST00000579208.1_Intron|KIAA0195_ENST00000375248.5_Nonsense_Mutation_p.Q156*|KIAA0195_ENST00000583795.1_3'UTR	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	146					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGGGAGATCCAGTGGCCCAG	0.597000													14	48					0	0	1	0	0
NAT6	24142	broad.mit.edu	37	3	50334221	50334221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50334221G>A	ENST00000443842.1	-	2	1481	c.674C>T	c.(673-675)cCa>cTa	p.P225L	HYAL3_ENST00000415204.1_Intron|HYAL3_ENST00000359051.3_Intron|HYAL3_ENST00000336307.1_Intron|NAT6_ENST00000443094.2_Missense_Mutation_p.P225L|NAT6_ENST00000354862.4_Missense_Mutation_p.P247L|NAT6_ENST00000417393.1_Missense_Mutation_p.P225L|HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000450982.1_Intron					N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		AGTCAGGTTTGGGGCCTTCCT	0.662000													20	43					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108112947	108112947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108112947C>T	ENST00000273353.3	-	37	5306	c.5250G>A	c.(5248-5250)caG>caA	p.Q1750Q		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1750						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CAGCTTCTTTCTGCATCCGGG	0.488000													51	82					0	0	1	0	0
SERPINI1	5274	broad.mit.edu	37	3	167512518	167512518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167512518C>T	ENST00000295777.5	+	5	1218	c.787C>T	c.(787-789)Cct>Tct	p.P263S	SERPINI1_ENST00000446050.2_Missense_Mutation_p.P263S	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	263					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						ACAGGAAGTTCCTCTTGCTAC	0.448000													23	42					0	0	1	0	0
OR7E24	26648	broad.mit.edu	37	19	9361945	9361945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9361945C>T	ENST00000456448.1	+	1	340	c.226C>T	c.(226-228)Ccc>Tcc	p.P76S		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						CCTCCACACCCCCATGTACTT	0.577000													21	76					0	0	1	0	0
HAP1	9001	broad.mit.edu	37	17	39888301	39888301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39888301C>T	ENST00000393939.2	-	4	793	c.784G>A	c.(784-786)Gag>Aag	p.E262K	HAP1_ENST00000310778.5_Missense_Mutation_p.E262K|HAP1_ENST00000347901.4_Missense_Mutation_p.E262K|HAP1_ENST00000341193.5_Missense_Mutation_p.E270K|JUP_ENST00000540235.1_Intron			P54257	HAP1_HUMAN	huntingtin-associated protein 1	262	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			tcctcatcctcctcATCAGAA	0.512000													12	19					0	0	1	0	0
NUDT21	11051	broad.mit.edu	37	16	56481894	56481894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56481894G>A	ENST00000300291.5	-	2	296	c.124C>T	c.(124-126)Ctt>Ttt	p.L42F		NM_007006.2	NP_008937.1	O43809	CPSF5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 21	42	Necessary for RNA-binding.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	centrosome|mRNA cleavage factor complex|paraspeckles	AU-rich element binding|histone deacetylase binding|hydrolase activity|mRNA binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)	7						TAATTGGTAAGAGGGTACCTG	0.393000													7	38					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	402001	402001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:402001G>A	ENST00000256509.2	+	12	1842	c.1200G>A	c.(1198-1200)agG>agA	p.R400R	CHL1_ENST00000397491.2_Silent_p.R384R	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	384	Ig-like C2-type 4.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TCTTCCCCAGGGAAATCAGTT	0.378000													29	109					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48736725	48736725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48736725G>A	ENST00000285238.8	+	7	882	c.802G>A	c.(802-804)Gca>Aca	p.A268T	ABCC3_ENST00000427699.1_Missense_Mutation_p.A268T	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	268					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AAAGCAGACGGCACGGTGAGG	0.622000													21	69					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38187400	38187400	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:38187400G>A	ENST00000317025.8	-	6	1594	c.1077C>T	c.(1075-1077)ccC>ccT	p.P359P	WHSC1L1_ENST00000527502.1_Silent_p.P359P|WHSC1L1_ENST00000433384.2_Silent_p.P359P|WHSC1L1_ENST00000316985.3_Silent_p.P359P	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	359					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TCTGAGGTCGGGGTTTCCGAA	0.363000			T	NUP98	AML								21	74					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16735650	16735650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16735650C>T	ENST00000335496.1	-	7	1118	c.636G>A	c.(634-636)gaG>gaA	p.E212E	SPATA21_ENST00000466212.1_5'UTR|SPATA21_ENST00000540400.1_Silent_p.E189E	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	212							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		CCTCGGACTTCTCCCGGTTTT	0.612000													24	54					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47511092	47511092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47511092G>A	ENST00000285039.7	-	8	1241	c.942C>T	c.(940-942)ctC>ctT	p.L314L		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	314	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CCTTACCGAGGAGTGTGAAGG	0.552000													23	62					0	0	1	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124239059	124239059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124239059C>T	ENST00000330342.3	+	18	2516	c.2268C>T	c.(2266-2268)ctC>ctT	p.L756L	ATP6V0A2_ENST00000544833.1_Silent_p.L38L	NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	756					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		ACCTGAGGCTCTGGGCGCTTA	0.507000													13	59					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27736193	27736193	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27736193G>A	ENST00000430629.2	-	8	1547	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	WASF2_ENST00000536657.1_Intron	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	444	WH2.				actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TACCTTGACGGATGGCTGAAA	0.572000													20	78					0	0	1	0	0
IL27	246778	broad.mit.edu	37	16	28513323	28513323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28513323C>T	ENST00000356897.1	-	4	458	c.436G>A	c.(436-438)Gat>Aat	p.D146N		NM_145659.3	NP_663634.2	Q8NEV9	IL27A_HUMAN	interleukin 27	146					inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	10						CGCTGCAGATCGCGGAGGTCC	0.652000													27	81					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031894	32031894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:32031894C>T	ENST00000360311.4	+	2	1872	c.1323C>T	c.(1321-1323)ctC>ctT	p.L441L		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	441					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						GTTCATATCTCGTAGTTCATT	0.378000													28	57					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020752	5020752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5020752C>T	ENST00000321543.1	+	1	540	c.540C>T	c.(538-540)ttC>ttT	p.F180F		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCACGCCTTCTGTTTGCACC	0.473000													21	116					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6174985	6174985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6174985C>T	ENST00000264870.3	-	12	1840	c.1575G>A	c.(1573-1575)gtG>gtA	p.V525V		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	525					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CAGCATTTTCCACTTCAAAGT	0.478000													24	42					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16962338	16962338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16962338C>T	ENST00000379803.1	+	6	856	c.842C>T	c.(841-843)cCc>cTc	p.P281L	SIN3B_ENST00000596802.1_Missense_Mutation_p.P281L|SIN3B_ENST00000248054.5_Missense_Mutation_p.P281L	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	281					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						GTGTCTGCACCCGCCAAGGTA	0.672000													14	70					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	124012331	124012331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124012331C>T	ENST00000456829.2	+	16	2157	c.1906C>T	c.(1906-1908)Cgt>Tgt	p.R636C	VWA5A_ENST00000360334.4_Silent_p.T397T|VWA5A_ENST00000392748.1_Missense_Mutation_p.R636C	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	636										autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						ACACTCTGACCGTCCTCCTTC	0.468000													50	107					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117686752	117686752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117686752G>A	ENST00000368508.3	-	19	3163	c.2965C>T	c.(2965-2967)Cat>Tat	p.H989Y	ROS1_ENST00000368507.3_Missense_Mutation_p.H984Y|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	989	Fibronectin type-III 4.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ACCTTAGAATGAGCACTAAAT	0.423000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								24	42					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211438116	211438116	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211438116A>T	ENST00000233072.5	+	2	417	c.221A>T	c.(220-222)aAt>aTt	p.N74I	CPS1_ENST00000430249.2_Missense_Mutation_p.N80I	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	74	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GTGGTTTTTAATACTGGCCTG	0.433000													21	93					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56057844	56057844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56057844C>T	ENST00000313022.2	-	1	722	c.695G>A	c.(694-696)gGa>gAa	p.G232E		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					TTTCTGCTTTCCTGAAGTGGA	0.383000													48	100					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10434094	10434094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10434094G>A	ENST00000293677.6	-	4	1037	c.956C>T	c.(955-957)cCc>cTc	p.P319L		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	302	Interaction with PTBP1 (By similarity).					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			ACTGCGGCCGGGGGGCCCAGG	0.711000													4	20					0	0	1	0	0
USP41	373856	broad.mit.edu	37	22	20729877	20729877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20729877G>A	ENST00000454608.2	-	6	302	c.303C>T	c.(301-303)ttC>ttT	p.F101F						ubiquitin specific peptidase 41											endometrium(1)|kidney(1)|lung(2)|skin(1)	5						GAAGCATCTGGAAAGGGACGC	0.572000													4	22					0	0	1	0	0
SPP2	6694	broad.mit.edu	37	2	234975199	234975199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234975199G>A	ENST00000168148.3	+	5	555	c.467G>A	c.(466-468)gGa>gAa	p.G156E	SPP2_ENST00000373368.1_Missense_Mutation_p.G156E	NM_006944.2	NP_008875.1	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa	156					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		GACATGTTGGGATCTCATAAA	0.308000													42	105					0	0	1	0	0
OR52B6	340980	broad.mit.edu	37	11	5602589	5602589	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5602589G>A	ENST00000345043.2	+	1	483	c.483G>A	c.(481-483)ggG>ggA	p.G161G	AC015691.13_ENST00000394793.2_RNA|HBG2_ENST00000380259.2_Intron	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGTCATTGGGAAGATCGTCA	0.512000													72	203					0	0	1	0	0
MIR587	693172	broad.mit.edu	37	6	107232091	107232091	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:107232091C>T	ENST00000384845.1	+	0	92					NR_030314.1																						aagcccatcccatatcccacc	0.547000													16	32					0	0	1	0	0
FBLIM1	54751	broad.mit.edu	37	1	16091552	16091552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16091552C>T	ENST00000375766.3	+	3	714	c.74C>T	c.(73-75)gCc>gTc	p.A25V	FBLIM1_ENST00000441801.2_Missense_Mutation_p.A25V|FBLIM1_ENST00000400773.1_Missense_Mutation_p.A25V|FBLIM1_ENST00000375771.1_Missense_Mutation_p.A25V|FBLIM1_ENST00000332305.5_Missense_Mutation_p.A25V	NM_017556.2	NP_060026.2	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	25	Filamin-binding.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		CGCGATGTGGCCGTGGCGGAG	0.672000													47	86					0	0	1	0	0
C11orf42	160298	broad.mit.edu	37	11	6231278	6231278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6231278G>A	ENST00000316375.2	+	2	321	c.271G>A	c.(271-273)Ggt>Agt	p.G91S		NM_173525.2	NP_775796.2	Q8N5U0	CK042_HUMAN	chromosome 11 open reading frame 42	91										endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|soft_tissue(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGATCTGAGGGTGCCTTCGC	0.622000													19	45					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74003537	74003537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74003537C>T	ENST00000301607.3	-	22	6002	c.5749G>A	c.(5749-5751)Gtg>Atg	p.V1917M	EVPL_ENST00000586740.1_Missense_Mutation_p.V1939M	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1917	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCCTCGCCCACCGAGAGCCTC	0.662000													9	61					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68396094	68396094	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68396094C>T	ENST00000297770.4	-	8	963		c.e8-1		CPA6_ENST00000297769.4_Splice_Site|CPA6_ENST00000518549.1_Splice_Site	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6						proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			AAAATCGATCCTAGACATAAT	0.398000													48	154					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115964637	115964637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115964637G>A	ENST00000251864.2	+	10	1435	c.1282G>A	c.(1282-1284)Gag>Aag	p.E428K	TDRD1_ENST00000422662.1_Missense_Mutation_p.E89K|TDRD1_ENST00000369281.2_Missense_Mutation_p.E428K|TDRD1_ENST00000369282.1_Missense_Mutation_p.E428K|TDRD1_ENST00000369280.1_Missense_Mutation_p.E428K	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	428					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGTAGAAGTTGAGCTGCCAAA	0.383000													28	72					0	0	1	0	0
G6PC2	57818	broad.mit.edu	37	2	169759040	169759040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169759040C>T	ENST00000375363.3	+	2	396	c.304C>T	c.(304-306)Cct>Tct	p.P102S	SPC25_ENST00000472216.2_Intron|G6PC2_ENST00000421979.1_Intron|G6PC2_ENST00000429379.2_Missense_Mutation_p.P102S	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	102					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						TGAACAGTTCCCTACTACATG	0.403000													40	74					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38704876	38704876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38704876G>A	ENST00000359357.3	+	4	399	c.145G>A	c.(145-147)Gga>Aga	p.G49R	DNAH8_ENST00000441566.1_Missense_Mutation_p.G49R|DNAH8_ENST00000449981.2_Missense_Mutation_p.G266R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGCGTCGAAAGGACTCTTAAA	0.398000													31	92					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36933542	36933542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36933542G>A	ENST00000373103.1	-	14	2292	c.1745C>T	c.(1744-1746)tCc>tTc	p.S582F	CSF3R_ENST00000338937.5_Missense_Mutation_p.S582F|CSF3R_ENST00000373106.1_Missense_Mutation_p.S582F|CSF3R_ENST00000361632.4_Missense_Mutation_p.S582F|CSF3R_ENST00000373104.1_Missense_Mutation_p.S582F|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000440588.2_Missense_Mutation_p.S582F|CSF3R_ENST00000418048.2_Missense_Mutation_p.S582F|CSF3R_ENST00000331941.5_Missense_Mutation_p.S582F	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	582	Fibronectin type-III 5.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	AAAGCCACGGGAGGAGGCATT	0.632000													10	55					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17675478	17675478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17675478G>A	ENST00000262077.2	-	4	704	c.705C>T	c.(703-705)gcC>gcT	p.A235A	NUP153_ENST00000537253.1_Silent_p.A235A	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	235					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GTGTTCCAAAGGCAGACAAGT	0.408000													25	74					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56081758	56081758	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56081758C>T	ENST00000257880.7	-	25	3531	c.3312G>A	c.(3310-3312)tgG>tgA	p.W1104*	ITGA7_ENST00000347027.6_Nonsense_Mutation_p.W1054*|ITGA7_ENST00000394230.2_Nonsense_Mutation_p.W1064*|ITGA7_ENST00000452168.2_Nonsense_Mutation_p.W967*|ITGA7_ENST00000553804.1_Nonsense_Mutation_p.W1064*|ITGA7_ENST00000555728.1_Nonsense_Mutation_p.W1104*|ITGA7_ENST00000394229.2_Nonsense_Mutation_p.W1060*|ITGA7_ENST00000257879.6_Nonsense_Mutation_p.W1060*			Q13683	ITA7_HUMAN	integrin, alpha 7	1104					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCCTCACCTTCCACAGGAGCA	0.592000													49	151					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80623121	80623121	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80623121C>T	ENST00000458043.2	+	7	553	c.547C>T	c.(547-549)Cga>Tga	p.R183*	OTOGL_ENST00000547103.1_Nonsense_Mutation_p.R183*	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						AGAGGAAATTCGAATTTATGG	0.348000													24	46					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35381118	35381118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35381118C>T	ENST00000378495.3	+	18	2372	c.2150C>T	c.(2149-2151)gCc>gTc	p.A717V	UNC13B_ENST00000396787.1_Missense_Mutation_p.A729V|UNC13B_ENST00000378496.4_Missense_Mutation_p.A717V	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	717					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GACAAATCAGCCGTCTCAGGG	0.488000													6	34					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145246231	145246231	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145246231G>A	ENST00000377976.1	-	2	396	c.397C>T	c.(397-399)Cga>Tga	p.R133*		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	133								p.R133*(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						ATTGGGGTTCGAATGATTTTC	0.398000													36	88					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95790940	95790940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95790940G>A	ENST00000260766.3	+	2	771	c.137G>A	c.(136-138)cGa>cAa	p.R46Q	PLCE1_ENST00000371380.2_Missense_Mutation_p.R46Q	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	46					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				ACTGTCAGACGAAGTGGGGAG	0.433000													34	97					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104048451	104048451	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104048451G>A	ENST00000374874.3	+	4	757	c.318G>A	c.(316-318)gaG>gaA	p.E106E	LPPR1_ENST00000395056.2_Silent_p.E106E	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		106						integral to membrane	catalytic activity										TTGCTCAGGAGAAAACAATTC	0.388000													14	101					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75017841	75017841	+	Missense_Mutation	SNP	G	G	A	rs147534770		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75017841G>A	ENST00000261978.4	-	7	1998	c.1612C>T	c.(1612-1614)Cgg>Tgg	p.R538W	LTBP2_ENST00000557425.1_5'UTR|LTBP2_ENST00000556690.1_Missense_Mutation_p.R538W	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	538					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGCAGTGGCCGAGGGGGCTCT	0.667000													15	51					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90016808	90016808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90016808G>A	ENST00000405460.2	+	45	9776	c.9680G>A	c.(9679-9681)cGa>cAa	p.R3227Q		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3227					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATGTATCTCGAACTAATGGC	0.393000													51	114					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241262032	241262032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:241262032C>T	ENST00000366565.1	-	3	490	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	RGS7_ENST00000366563.1_Missense_Mutation_p.E37K|RGS7_ENST00000446183.2_5'UTR|RGS7_ENST00000366562.4_Missense_Mutation_p.E37K|RGS7_ENST00000401882.1_Missense_Mutation_p.E37K|RGS7_ENST00000331110.7_Missense_Mutation_p.E11K|RGS7_ENST00000348120.2_Missense_Mutation_p.E37K|RGS7_ENST00000366564.1_Missense_Mutation_p.E37K|RGS7_ENST00000407727.1_Missense_Mutation_p.E37K	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	37	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CCATTTTTTTCATCTTGCATC	0.348000													22	37					0	0	1	0	0
CCDC74A	90557	broad.mit.edu	37	2	132288272	132288272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132288272C>T	ENST00000467992.2	+	1	1036	c.722C>T	c.(721-723)tCc>tTc	p.S241F	CCDC74A_ENST00000295171.6_Missense_Mutation_p.S139F|CCDC74A_ENST00000409856.3_Intron			Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	139										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						AAGGAGGGCTCCTCACGGACA	0.662000													21	92					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93125602	93125602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93125602C>T	ENST00000216487.7	+	7	2282	c.2123C>T	c.(2122-2124)tCg>tTg	p.S708L	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	708	Interaction with RAB5B.|VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding	p.S708L(2)		endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				AAGGATGGTTCGCTGCAGCAG	0.547000													56	200					0	0	1	0	0
LFNG	3955	broad.mit.edu	37	7	2559870	2559870	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2559870C>T	ENST00000222725.5	+	1	395	c.375C>T	c.(373-375)ttC>ttT	p.F125F	LFNG_ENST00000402045.1_Intron|LFNG_ENST00000338732.3_Intron|LFNG_ENST00000402506.1_Intron|LFNG_ENST00000359574.3_Silent_p.F125F	NM_001040167.1	NP_001035257.1	Q8NES3	LFNG_HUMAN	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	125					organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)|urinary_tract(2)	6		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		CCAAAAAGTTCCACCGCGCGC	0.751000													16	47					0	0	1	0	0
RNF125	54941	broad.mit.edu	37	18	29645969	29645969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29645969C>T	ENST00000217740.3	+	5	1101	c.609C>T	c.(607-609)ttC>ttT	p.F203F	RP11-53I6.2_ENST00000583184.1_RNA|RNF125_ENST00000583384.1_3'UTR	NM_017831.3	NP_060301.2	Q96EQ8	RN125_HUMAN	ring finger protein 125, E3 ubiquitin protein ligase	203					negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						ATGATGATTTCATAGTAAGTA	0.328000													34	82					0	0	1	0	0
NUTM2A	728118	broad.mit.edu	37	10	88988177	88988177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88988177C>T	ENST00000381689.4	+	2	871	c.540C>T	c.(538-540)acC>acT	p.T180T	NUTM2A_ENST00000381707.2_Silent_p.T180T|NUTM2A-AS1_ENST00000451940.2_RNA					NUT family member 2A																		TGCTGTCTACCCTCCCCAGCA	0.677000													28	183					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207639872	207639872	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207639872G>A	ENST00000367057.3	+	2	249	c.58_splice	c.e2-1	p.G20_splice	CR2_ENST00000367058.3_Splice_Site_p.G20_splice|CR2_ENST00000458541.2_Splice_Site_p.G20_splice|CR2_ENST00000367059.3_Splice_Site_p.G20_splice	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	20					complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						ACTTTTCAGGGATTTCTTGTG	0.383000													66	186					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2211187	2211187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2211187C>T	ENST00000398665.3	+	15	1477	c.1441C>T	c.(1441-1443)Ccg>Tcg	p.P481S		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	481						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGCCCACCCCGCCCGCGCT	0.677000													29	68					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819490	43819490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43819490G>A	ENST00000382031.1	+	5	6564	c.6533G>A	c.(6532-6534)aGc>aAc	p.S2178N	MAP1A_ENST00000399453.1_Missense_Mutation_p.S1940N|MAP1A_ENST00000300231.5_Missense_Mutation_p.S1940N			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1940						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GCCAGCAAAAGCCATGCCACC	0.547000													37	73					0	0	1	0	0
AGMAT	79814	broad.mit.edu	37	1	15905504	15905504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15905504C>T	ENST00000375826.3	-	4	712	c.570G>A	c.(568-570)acG>acA	p.T190T	DNAJC16_ENST00000483270.1_Intron	NM_024758.4	NP_079034.3	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase)	190					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(2)|skin(1)	12		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		CCTTGTCGGTCGTGTCCGTGT	0.642000													15	46					0	0	1	0	0
ZNF414	84330	broad.mit.edu	37	19	8576620	8576620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8576620G>A	ENST00000393927.4	-	5	868	c.755C>T	c.(754-756)cCg>cTg	p.P252L	ZNF414_ENST00000255616.8_Missense_Mutation_p.P252L	NM_001146175.1	NP_001139647.1	Q96IQ9	ZN414_HUMAN	zinc finger protein 414	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(2)	2						GGGCAGGAACGGTCCGGTGGG	0.766000													3	4					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76828852	76828852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76828852C>T	ENST00000248598.5	-	1	291	c.259G>A	c.(259-261)Gaa>Aaa	p.E87K	CCDC146_ENST00000285871.4_Intron|CCDC146_ENST00000431197.1_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	87					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						TTTACGATTTCCTTGAGGTTT	0.507000													31	88					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413062	124413062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124413062C>T	ENST00000306842.2	-	1	513	c.489G>A	c.(487-489)atG>atA	p.M163I		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		AGGTCAGGTTCATTATGCTTC	0.502000													33	81					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22211865	22211865	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22211865G>A	ENST00000374695.3	-	10	1237	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	386	LDL-receptor class A 4.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGTCACAGTGGAAGCTGGCTG	0.627000													11	49					0	0	1	0	0
USP2	9099	broad.mit.edu	37	11	119228486	119228486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119228486G>A	ENST00000260187.2	-	10	1776	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	USP2_ENST00000455332.2_Silent_p.F251F|USP2_ENST00000525735.1_Silent_p.F285F	NM_004205.4	NP_004196.4	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2	494	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	24		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		AGATCTTTGGGAACCTCTGGA	0.498000													167	402					0	0	1	0	0
EGR1	1958	broad.mit.edu	37	5	137802597	137802597	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137802597C>T	ENST00000239938.4	+	2	731	c.459C>T	c.(457-459)ccC>ccT	p.P153P		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	153					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GGCCCGAGCCCCTCTTCAGCT	0.637000													45	131					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542280	55542280	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55542280C>T	ENST00000220676.1	+	4	5986	c.5838C>T	c.(5836-5838)ttC>ttT	p.F1946F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1946					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGAAAATTTCTTGGGTTTTT	0.343000													22	98					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584325	82584325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82584325C>T	ENST00000423517.2	-	5	6281	c.5944G>A	c.(5944-5946)Gga>Aga	p.G1982R	PCLO_ENST00000333891.8_Missense_Mutation_p.G1982R	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1913					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGCATAAATCCATTTTCTTCT	0.363000													37	158					0	0	1	0	0
ASPG	374569	broad.mit.edu	37	14	104565220	104565220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104565220C>T	ENST00000551177.1	+	6	636	c.544C>T	c.(544-546)Cgg>Tgg	p.R182W	ASPG_ENST00000546892.2_Missense_Mutation_p.R182W|ASPG_ENST00000455920.2_Missense_Mutation_p.R182W	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	182	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						TCAGCTGTTTCGGGGCAACCG	0.607000													5	24					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112031331	112031331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112031331C>T	ENST00000369716.4	-	3	906	c.773G>A	c.(772-774)gGa>gAa	p.G258E	ADORA3_ENST00000369717.4_Missense_Mutation_p.G177E	NM_020683.6	NP_065734.5	P33765	AA3R_HUMAN	adenosine A3 receptor	0					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GGCCAGGGTTCCTTTGTCGTC	0.537000													8	40					0	0	1	0	0
TFCP2	7024	broad.mit.edu	37	12	51512411	51512411	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51512411G>A	ENST00000307660.4	-	2	987	c.267C>T	c.(265-267)ctC>ctT	p.L89L	TFCP2_ENST00000549867.1_Silent_p.L89L|TFCP2_ENST00000257915.5_Silent_p.L89L|TFCP2_ENST00000548115.1_Silent_p.L89L	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	89					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						AACCTTGATTGAGATACGTTA	0.393000													11	114					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306738	41306738	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:41306738G>A	ENST00000373198.3	-	7	1156	c.921C>T	c.(919-921)atC>atT	p.I307I	PTPRT_ENST00000373187.1_Silent_p.I307I|PTPRT_ENST00000373193.3_Silent_p.I307I|PTPRT_ENST00000373201.1_Silent_p.I307I|PTPRT_ENST00000373184.1_Silent_p.I307I|PTPRT_ENST00000356100.2_Silent_p.I307I|PTPRT_ENST00000373190.1_Silent_p.I307I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	307	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CATTTGGCTTGATCCACAGGT	0.552000													11	36					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100395072	100395072	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100395072G>A	ENST00000542585.1	+	0	8561				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCATTTACAGAACGAGGAGG	0.622000													17	51					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70530546	70530546	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70530546G>A	ENST00000357887.3	-	3	2638	c.1885C>T	c.(1885-1887)Cag>Tag	p.Q629*	SLC8A3_ENST00000528359.1_Nonsense_Mutation_p.Q629*|SLC8A3_ENST00000216568.7_Intron|SLC8A3_ENST00000534137.1_Intron|SLC8A3_ENST00000533541.1_Intron|SLC8A3_ENST00000356921.2_Intron|SLC8A3_ENST00000381269.2_Intron|SLC8A3_ENST00000394330.2_Intron	NM_033262.3	NP_150287.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	628					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ACACCTTTCTGAAAACTCATA	0.423000													8	83					0	0	1	0	0
NMU	10874	broad.mit.edu	37	4	56471487	56471487	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:56471487G>A	ENST00000264218.3	-	7	495	c.390C>T	c.(388-390)ctC>ctT	p.L130L	NMU_ENST00000511469.1_Silent_p.L114L|NMU_ENST00000515325.1_5'UTR|NMU_ENST00000505262.1_Silent_p.L103L|NMU_ENST00000507338.1_Intron	NM_006681.2	NP_006672.1	P48645	NMU_HUMAN	neuromedin U	130					neuropeptide signaling pathway	extracellular region				lung(3)|ovary(1)|urinary_tract(1)	5	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		GGTGAGGAACGAGCTGCAGCA	0.502000													29	83					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163510	32163510	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32163510G>A	ENST00000564145.1	-	0	65																											TGCCCTTCGGGGTGATGCCAG	0.547000													10	78					0	0	1	0	0
GABRR2	2570	broad.mit.edu	37	6	89975401	89975401	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:89975401G>A	ENST00000402938.3	-	7	953	c.820C>T	c.(820-822)Ctg>Ttg	p.L274L	GABRR2_ENST00000602399.1_Silent_p.L299L			P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	299					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		ATGACCATCAGAGTGGCAGGG	0.512000													33	38					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51749832	51749832	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51749832C>T	ENST00000395052.3	+	4	2277	c.2043C>T	c.(2041-2043)gcC>gcT	p.A681A	GRM2_ENST00000442933.2_Intron|GRM2_ENST00000475478.1_3'UTR	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	681					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CACAGGTGGCCATCTGCCTGG	0.677000													9	39					0	0	1	0	0
MTFR1	9650	broad.mit.edu	37	8	66620087	66620087	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:66620087A>G	ENST00000262146.4	+	7	900	c.774A>G	c.(772-774)caA>caG	p.Q258Q	MTFR1_ENST00000458689.2_Silent_p.Q225Q|MTFR1_ENST00000517944.1_3'UTR	NM_014637.3	NP_055452.3	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1	258						mitochondrion|plasma membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|pancreas(1)|urinary_tract(1)	11			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			GGTCAGAGCAAGATGTGAAGC	0.488000													17	64					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32233121	32233121	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32233121T>G	ENST00000400246.1	+	26	2476	c.2334T>G	c.(2332-2334)ctT>ctG	p.L778L	DEPDC5_ENST00000382111.2_Silent_p.L778L|DEPDC5_ENST00000400248.1_Silent_p.L769L|DEPDC5_ENST00000400249.2_Silent_p.L769L|DEPDC5_ENST00000382105.2_Silent_p.L700L|DEPDC5_ENST00000535622.1_Silent_p.L700L|DEPDC5_ENST00000266091.3_Silent_p.L778L|DEPDC5_ENST00000382112.3_Silent_p.L769L			O75140	DEPD5_HUMAN	DEP domain containing 5	769					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ATGATCTCCTTCCAGAAGCAG	0.532000													8	88					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155199125	155199125	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155199125G>A	ENST00000460012.1	-	23	4957	c.4600C>T	c.(4600-4602)Cgg>Tgg	p.R1534W	PLCH1_ENST00000414191.1_Missense_Mutation_p.R1534W|PLCH1_ENST00000340059.7_Missense_Mutation_p.R1572W|PLCH1_ENST00000334686.6_Missense_Mutation_p.R1534W|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000494598.1_Intron			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1572					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			ACCAGTGCCCGGGGGAGCTGA	0.512000													23	98					0	0	1	0	0
LBR	3930	broad.mit.edu	37	1	225609926	225609926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:225609926G>A	ENST00000338179.2	-	3	344	c.219C>T	c.(217-219)tcC>tcT	p.S73S	LBR_ENST00000272163.4_Silent_p.S73S	NM_194442.2	NP_919424.1	Q14739	LBR_HUMAN	lamin B receptor	73	Nucleoplasmic (Potential).				cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		CTCGGCGTCTGGAAGGGGAAC	0.532000													8	77					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130281490	130281490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130281490C>T	ENST00000257359.6	-	6	2278	c.1572G>A	c.(1570-1572)gtG>gtA	p.V524V		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	524	Disintegrin.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CTCCATCTGCCACGGGCTGCA	0.582000													16	47					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581300	234581300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234581300G>A	ENST00000354728.4	+	1	802	c.720G>A	c.(718-720)acG>acA	p.T240T	UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		CACCTGTTACGGAGTATGATC	0.428000													171	445					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48936161	48936161	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48936161C>T	ENST00000294954.7	-	8	627	c.605_splice	c.e8-1	p.L202_splice	LHCGR_ENST00000405626.1_Splice_Site_p.L202_splice|LHCGR_ENST00000403273.1_Splice_Site_p.L202_splice|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000344775.3_Splice_Site_p.L202_splice|LHCGR_ENST00000401907.1_Splice_Site_p.L202_splice	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	202					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	CCTTTAGCTCCCTGTGGGGAA	0.488000													28	86					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75818801	75818801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:75818801C>T	ENST00000322507.8	-	52	8342	c.8033G>A	c.(8032-8034)gGa>gAa	p.G2678E	COL12A1_ENST00000483888.2_Missense_Mutation_p.G2678E|COL12A1_ENST00000416123.2_Intron|COL12A1_ENST00000345356.6_Missense_Mutation_p.G1514E	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2678	Nonhelical region (NC3).|TSP N-terminal.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength	p.G2678V(1)		breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TGTTATATTTCCAGCTTCCTT	0.323000													6	72					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625528	140625528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140625528G>A	ENST00000231173.3	+	1	382	c.382G>A	c.(382-384)Gat>Aat	p.D128N		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		128	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGACATAAACGATCATTCTCC	0.438000													57	143					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17091331	17091331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17091331G>A	ENST00000443236.1	-	14	1733	c.1702C>T	c.(1702-1704)Cgt>Tgt	p.R568C	CPAMD8_ENST00000388925.4_Intron	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	521						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TGTGTTAAACGAATCGGTTTC	0.592000													16	77					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098545	144098545	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:144098545G>A	ENST00000467773.1	-	4	437	c.438C>T	c.(436-438)gtC>gtT	p.V146V	NOBOX_ENST00000223140.5_Silent_p.V61V|NOBOX_ENST00000483238.1_Silent_p.V146V	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	146					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					CTTCTCCAGAGACTGCTGGCG	0.647000													19	35					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33502596	33502596	+	Silent	SNP	G	G	A	rs144422380		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:33502596G>A	ENST00000265371.4	-	10	1857	c.1332C>T	c.(1330-1332)gaC>gaT	p.D444D	NRP1_ENST00000395995.1_Silent_p.D444D|NRP1_ENST00000374867.2_Silent_p.D444D|NRP1_ENST00000374822.4_Silent_p.D444D|RP11-342D11.2_ENST00000451530.1_RNA|NRP1_ENST00000374821.5_Silent_p.D444D|NRP1_ENST00000374823.5_Silent_p.D444D|NRP1_ENST00000374816.3_Silent_p.D444D			O14786	NRP1_HUMAN	neuropilin 1	444	F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	TGATCTGGGAGTCAGAAATAA	0.493000													8	122					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158254056	158254056	+	Missense_Mutation	SNP	G	G	A	rs142538282	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:158254056G>A	ENST00000296526.7	+	7	1293	c.968G>A	c.(967-969)cGa>cAa	p.R323Q	GRIA2_ENST00000507898.1_Missense_Mutation_p.R276Q|GRIA2_ENST00000449365.1_Missense_Mutation_p.R276Q|GRIA2_ENST00000264426.9_Missense_Mutation_p.R323Q|GRIA2_ENST00000393815.2_Missense_Mutation_p.R276Q	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	323					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GAAATCTCCCGAAGGGGGAAT	0.478000													18	88					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230746	56230746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56230746G>A	ENST00000279791.1	-	1	131	c.132C>T	c.(130-132)atC>atT	p.I44I		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					TAATCAAAATGATCATACCAA	0.473000													16	47					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55939046	55939046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55939046C>T	ENST00000244728.5	-	20	2346	c.1949G>A	c.(1948-1950)gGa>gAa	p.G650E	COL21A1_ENST00000535941.1_Missense_Mutation_p.G650E|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.G50E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G647E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	650	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TCCCGGTGTTCCAGGCTGGCC	0.323000													34	105					0	0	1	0	0
PODXL	5420	broad.mit.edu	37	7	131191022	131191022	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131191022C>T	ENST00000541194.1	-	7	1571	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K	PODXL_ENST00000322985.9_Silent_p.K404K|PODXL_ENST00000537928.1_Silent_p.K404K|PODXL_ENST00000378555.3_Silent_p.K436K	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	436					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					CGCTTACCTCCTTTAGTTCAT	0.607000													50	116					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99441587	99441587	+	Silent	SNP	G	G	A	rs141454693	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:99441587G>A	ENST00000287042.4	+	2	1730	c.1380G>A	c.(1378-1380)acG>acA	p.T460T	KCNS2_ENST00000521839.1_Silent_p.T460T	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	460						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CAAGCCTGACGAACATGAGCA	0.493000													40	82					0	0	1	0	0
LBX1	10660	broad.mit.edu	37	10	102987154	102987154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102987154C>T	ENST00000370193.2	-	2	1697	c.719G>A	c.(718-720)gGc>gAc	p.G240D		NM_006562.4	NP_006553.2	P52954	LBX1_HUMAN	ladybird homeobox 1	240					muscle organ development		sequence-specific DNA binding			large_intestine(2)|lung(4)|ovary(1)	7		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		CTTCGGGGCGCCTGGGGGGAG	0.756000													7	19					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57929968	57929968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57929968G>A	ENST00000574161.1	+	9	1128	c.1009G>A	c.(1009-1011)Gaa>Aaa	p.E337K	GCOM1_ENST00000380561.2_Missense_Mutation_p.E306K|GCOM1_ENST00000572390.1_Missense_Mutation_p.E337K|GCOM1_ENST00000380560.2_Missense_Mutation_p.E268K|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Missense_Mutation_p.E337K|GCOM1_ENST00000587652.1_Missense_Mutation_p.E337K|GCOM1_ENST00000396180.1_Missense_Mutation_p.E306K|MYZAP_ENST00000267853.5_Missense_Mutation_p.E337K|GCOM1_ENST00000380568.3_Missense_Mutation_p.E337K|MYZAP_ENST00000380565.4_Missense_Mutation_p.E337K	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		337					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						TTCTGACAAGGAAAGGTAAGA	0.383000													8	21					0	0	1	0	0
MOS	4342	broad.mit.edu	37	8	57025542	57025542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57025542G>A	ENST00000311923.1	-	1	999	c.1000C>T	c.(1000-1002)Ctt>Ttt	p.L334F		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog	334	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			TCCACCAAAAGCAGCCGCGCG	0.567000													8	32					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65789247	65789247	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65789247C>T	ENST00000312106.5	-	3	1670	c.1533G>A	c.(1531-1533)tgG>tgA	p.W511*		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	511					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CCAAATTGTTCCAGAAGTCAA	0.592000													14	82					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179665278	179665278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179665278C>T	ENST00000589042.1	-	4	651	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	TTN_ENST00000342992.6_Missense_Mutation_p.E143K|TTN_ENST00000360870.5_Missense_Mutation_p.E143K|TTN_ENST00000591111.1_Missense_Mutation_p.E143K|TTN_ENST00000342175.6_Missense_Mutation_p.E143K|TTN_ENST00000359218.5_Missense_Mutation_p.E143K|TTN_ENST00000460472.2_Missense_Mutation_p.E143K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	143	Ig-like 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGGATTTCGGCTCCATCC	0.502000													44	109					0	0	1	0	0
MITF	4286	broad.mit.edu	37	3	70014033	70014033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:70014033C>T	ENST00000352241.4	+	10	1360	c.1197C>T	c.(1195-1197)tcC>tcT	p.S399S	MITF_ENST00000394355.2_Silent_p.S374S|MITF_ENST00000328528.6_Silent_p.S398S|MITF_ENST00000314557.6_Silent_p.S292S|MITF_ENST00000394351.3_Silent_p.S298S|MITF_ENST00000448226.2_Silent_p.S405S|MITF_ENST00000531774.1_Silent_p.S236S|MITF_ENST00000472437.1_Silent_p.S347S|MITF_ENST00000314589.5_Silent_p.S383S	NM_198159.2	NP_937802.1	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	405					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(6)|stomach(1)|urinary_tract(2)	30		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		ATGGACTTTCCCTTATTCCAT	0.453000			A		melanoma		"""Waardenburg syndrome type 2, Tietz syndrome"""						38	96					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9560897	9560897	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9560897C>T	ENST00000378429.3	-	5	1431	c.885G>A	c.(883-885)ccG>ccA	p.P295P	PAK7_ENST00000378423.1_Silent_p.P295P|PAK7_ENST00000353224.5_Silent_p.P295P	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	295	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			ATGGCATCATCGGTTCCTGGA	0.542000													52	139					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50266481	50266481	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50266481C>T	ENST00000246801.3	-	1	106	c.24G>A	c.(22-24)acG>acA	p.T8T		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	8							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		ACTGCCAGATCGTCTTCACCA	0.647000													52	92					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896749	175896749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175896749C>T	ENST00000359240.3	+	5	743	c.73C>T	c.(73-75)Ccc>Tcc	p.P25S	ADAM29_ENST00000445694.1_Missense_Mutation_p.P25S|ADAM29_ENST00000404450.4_Missense_Mutation_p.P25S|ADAM29_ENST00000514159.1_Missense_Mutation_p.P25S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	25					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GGATGAGCACCCCCAATATCA	0.512000													19	58					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106526727	106526727	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:106526727A>G	ENST00000359195.3	+	10	3330	c.3020A>G	c.(3019-3021)cAg>cGg	p.Q1007R	PIK3CG_ENST00000440650.2_Missense_Mutation_p.Q1007R|PIK3CG_ENST00000496166.1_Missense_Mutation_p.Q1007R	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1007	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						CCACACTTCCAGAAATTTCAG	0.493000													24	48					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6238577	6238577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6238577G>A	ENST00000524416.1	-	9	2549	c.2239C>T	c.(2239-2241)Ccc>Tcc	p.P747S	FAM160A2_ENST00000265978.4_Intron|FAM160A2_ENST00000449352.2_Intron			Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	743					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACACAGAAGGGAAGGCCTAGG	0.552000													19	27					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11154776	11154776	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11154776C>T	ENST00000409790.1	+	19	2243	c.2013C>T	c.(2011-2013)ttC>ttT	p.F671F	CLEC16A_ENST00000465491.1_3'UTR|CLEC16A_ENST00000409552.3_Silent_p.F653F	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	671								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GGGTGTTCTTCATGCTGCGTT	0.542000													64	234					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20665659	20665659	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20665659C>T	ENST00000357366.3	+	1	165	c.165C>T	c.(163-165)ttC>ttT	p.F55F		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TCCTGGGCTTCCCTTGCCCCA	0.512000													19	55					0	0	1	0	0
UBE2Q2	92912	broad.mit.edu	37	15	76175737	76175737	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:76175737C>T	ENST00000267938.4	+	9	1238	c.856C>T	c.(856-858)Cga>Tga	p.R286*	UBE2Q2_ENST00000569423.1_Nonsense_Mutation_p.R251*|UBE2Q2_ENST00000561851.1_Nonsense_Mutation_p.R270*|UBE2Q2_ENST00000338677.4_Nonsense_Mutation_p.R286*	NM_173469.2	NP_775740.1	Q8WVN8	UB2Q2_HUMAN	ubiquitin-conjugating enzyme E2Q family member 2	286					protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	12						TCCATTTGTTCGAGTGGTGTT	0.284000													28	81					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109103252	109103252	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:109103252C>T	ENST00000261483.4	+	6	1904	c.852C>T	c.(850-852)tcC>tcT	p.S284S		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	284					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding	p.S284S(1)		breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		AACCTCGGTCCGGCTGGGCTA	0.388000													51	92					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140409953	140409953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140409953C>T	ENST00000286349.3	+	4	2195	c.2004C>T	c.(2002-2004)aaC>aaT	p.N668N		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	668	Fibronectin type-III.					intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AGCTGCACAACCTGACCCCCA	0.428000													45	109					0	0	1	0	0
USPL1	10208	broad.mit.edu	37	13	31232685	31232685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:31232685C>T	ENST00000255304.4	+	9	2813	c.2471C>T	c.(2470-2472)cCc>cTc	p.P824L		NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	824					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AAGCCTCCTCCCATCAGTAAG	0.483000													30	79					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566459	5566459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5566459C>T	ENST00000322653.4	-	1	320	c.295G>A	c.(295-297)Gaa>Aaa	p.E99K	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E99K(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AATGTGATTTCGCGAGCCCCT	0.468000													30	43					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34087766	34087766	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34087766C>T	ENST00000373381.4	-	37	6004		c.e37+1		CSMD2_ENST00000373380.1_Splice_Site|CSMD2_ENST00000373377.1_Splice_Site|CSMD2_ENST00000373388.2_Splice_Site	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGATTCTCACTTTTGTACTC	0.507000													76	153					0	0	1	0	0
HHAT	55733	broad.mit.edu	37	1	210577852	210577852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210577852C>T	ENST00000367010.1	+	6	740	c.513C>T	c.(511-513)ttC>ttT	p.F171F	HHAT_ENST00000391905.3_Silent_p.F171F|HHAT_ENST00000545154.1_Silent_p.F172F|HHAT_ENST00000413764.2_Silent_p.F171F|HHAT_ENST00000545781.1_Silent_p.F108F|HHAT_ENST00000308852.6_Silent_p.F126F|HHAT_ENST00000537898.1_Silent_p.F106F|HHAT_ENST00000541565.1_Intron|HHAT_ENST00000261458.3_Silent_p.F171F	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	171					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		TGCTGCAGTTCACGCTGACCG	0.542000													28	46					0	0	1	0	0
TAGAP	117289	broad.mit.edu	37	6	159462467	159462467	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159462467C>T	ENST00000367066.3	-	6	727	c.396G>A	c.(394-396)aaG>aaA	p.K132K	TAGAP_ENST00000326965.6_5'UTR|RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA|TAGAP_ENST00000338313.5_Silent_p.K132K|RP1-111C20.4_ENST00000606466.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	132	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CCTTCAGCTCCTTACGGGCTT	0.522000													24	48					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93104242	93104242	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93104242A>T	ENST00000298050.3	+	7	685	c.585A>T	c.(583-585)aaA>aaT	p.K195N		NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	195										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TAAATGGTAAAAAACAGTGCT	0.328000													15	21					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41040073	41040073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41040073G>A	ENST00000352632.3	+	20	4268	c.4182G>A	c.(4180-4182)gaG>gaA	p.E1394E	SPTBN4_ENST00000392025.1_Silent_p.E137E|SPTBN4_ENST00000598249.1_Silent_p.E1394E|SPTBN4_ENST00000392023.1_Silent_p.E70E|SPTBN4_ENST00000595535.1_Silent_p.E1394E|SPTBN4_ENST00000338932.3_Silent_p.E1394E			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1394					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCTGGGCGGAGCTGGAGAGCA	0.642000													11	18					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1943503	1943503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1943503C>T	ENST00000543818.1	+	5	1571	c.729C>T	c.(727-729)ccC>ccT	p.P243P	CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000588077.1_Intron|LRTM2_ENST00000543730.1_3'UTR|LRTM2_ENST00000299194.1_Silent_p.P243P|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000382722.5_Intron|LRTM2_ENST00000535041.1_Silent_p.P243P	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	243	LRRCT.					integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GGATGGTCCCCATGGAGATGT	0.597000													13	43					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15299893	15299893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15299893C>T	ENST00000263388.2	-	8	1360	c.1285G>A	c.(1285-1287)Gag>Aag	p.E429K		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	429	EGF-like 10; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			ACATCGGTCTCACAGCGAGGT	0.642000													25	59					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538257	55538257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55538257C>T	ENST00000220676.1	+	4	1963	c.1815C>T	c.(1813-1815)ttC>ttT	p.F605F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	605					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATGATAGGTTCAGTCCTATTT	0.378000													33	109					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3827613	3827613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3827613C>T	ENST00000262961.4	-	6	901	c.891G>A	c.(889-891)aaG>aaA	p.K297K		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	297						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CCGCCTCCTTCTTTCTGTGCT	0.692000													3	5					0	0	1	0	0
OR51B2	79345	broad.mit.edu	37	11	5344952	5344952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5344952G>A	ENST00000328813.2	-	1	630	c.576C>T	c.(574-576)ttC>ttT	p.F192F	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F192L(1)		NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGTCTATTGAAAGTTATGT	0.363000													20	46					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10108085	10108085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10108085G>A	ENST00000264828.3	-	11	1310	c.1225C>T	c.(1225-1227)Ccc>Tcc	p.P409S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	409	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGGGGGCCGGGAGGGCCTGAG	0.602000													9	7					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612645	179612645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179612645G>A	ENST00000360870.5	-	46	14704	c.14482C>T	c.(14482-14484)Ctg>Ttg	p.L4828L	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	938	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGACTCAGGGAGAGCTGT	0.448000													21	51					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110836623	110836623	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110836623G>A	ENST00000502322.1	-	5	688	c.474C>T	c.(472-474)tcC>tcT	p.S158S	STARD4_ENST00000511569.1_5'UTR|STARD4_ENST00000512160.1_Intron|STARD4_ENST00000296632.3_Intron|STARD4_ENST00000509887.1_3'UTR			Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	0	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		TATCTCACAAGGAAAGAGACA	0.308000													16	42					0	0	1	0	0
IGLV2-8	28817	broad.mit.edu	37	22	23165508	23165508	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23165508C>T	ENST00000390317.2	+	0	241																											GACTCAGCCTCCCTCCGCGTC	0.592000													113	286					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169690824	169690824	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169690824G>T	ENST00000444448.2	+	9	969	c.493G>T	c.(493-495)Gag>Tag	p.E165*	NOSTRIN_ENST00000458381.2_Nonsense_Mutation_p.E165*|NOSTRIN_ENST00000421711.2_Nonsense_Mutation_p.E137*|NOSTRIN_ENST00000397209.2_Nonsense_Mutation_p.E137*|NOSTRIN_ENST00000317647.7_Nonsense_Mutation_p.E165*|NOSTRIN_ENST00000397206.2_Nonsense_Mutation_p.E87*|NOSTRIN_ENST00000445023.2_Nonsense_Mutation_p.E87*			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	165					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						GACTGAGAAGGAGAAGCGGAA	0.458000													14	56					0.000219431	0.000219733	1	1	0
NOTCH2	4853	broad.mit.edu	37	1	120458025	120458025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120458025G>A	ENST00000256646.2	-	34	7539	c.7320C>T	c.(7318-7320)acC>acT	p.T2440T		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	2440					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAGGGCTGGTGGTCACATCTG	0.582000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				22	110					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33292591	33292591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:33292591G>A	ENST00000280979.4	+	13	5742	c.5572G>A	c.(5572-5574)Gaa>Aaa	p.E1858K	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1858					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ACGTGTCTCTGAAAATAATGG	0.353000													36	68					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113146034	113146034	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113146034G>A	ENST00000316851.7	+	18	2472	c.2472G>A	c.(2470-2472)acG>acA	p.T824T	NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	834					axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AGACAGAAACGAAGCCAGCGC	0.547000													11	26					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30740710	30740710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30740710C>T	ENST00000262518.4	+	27	6329	c.5944C>T	c.(5944-5946)Cct>Tct	p.P1982S	SRCAP_ENST00000344771.4_Missense_Mutation_p.P1824S|SRCAP_ENST00000395059.2_Missense_Mutation_p.P1920S	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1982					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TGTCATGCCTCCTGTGGAGGC	0.567000													14	32					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124528805	124528805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:124528805C>T	ENST00000408936.3	+	9	1675	c.1493C>T	c.(1492-1494)gCc>gTc	p.A498V	DAB2IP_ENST00000309989.1_Missense_Mutation_p.A374V|DAB2IP_ENST00000259371.2_Missense_Mutation_p.A470V			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	498	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GAGGTGTTTGCCTCGTGGAGG	0.627000													16	32					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76965231	76965231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76965231G>A	ENST00000261532.7	+	8	1531	c.1459G>A	c.(1459-1461)Gag>Aag	p.E487K	ESRRB_ENST00000509242.1_Intron|RP11-187O7.3_ENST00000554926.1_lincRNA|ESRRB_ENST00000380887.2_Intron			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	0						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		ATACCACCTGGAGGTTTTCCT	0.602000													10	24					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5247821	5247821	+	Missense_Mutation	SNP	G	G	A	rs63750556		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5247821G>A	ENST00000335295.3	-	2	476	c.301C>T	c.(301-303)Cct>Tct	p.P101S		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	101			P -> L (in Brigham; O(2) affinity up).|P -> R (in New Mexico).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	AAGTTCTCAGGATCCACGTGC	0.502000									Sickle Cell Trait				23	78					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189706735	189706735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189706735G>A	ENST00000319332.5	-	4	1113	c.916C>T	c.(916-918)Cct>Tct	p.P306S	LEPREL1_ENST00000427335.2_Missense_Mutation_p.P125S	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	306					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TAGTGCAGAGGAAGAAAATTC	0.493000													44	92					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111957747	111957747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111957747G>A	ENST00000369732.3	-	11	1431	c.1376C>T	c.(1375-1377)tCc>tTc	p.S459F		NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	459					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CTTTCCAAGGGATACAGTTTC	0.502000													28	74					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325048	57325048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57325048C>T	ENST00000326441.9	-	10	5125	c.4762G>A	c.(4762-4764)Ggc>Agc	p.G1588S	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.G1464S|PEG3_ENST00000593695.1_Missense_Mutation_p.G1462S|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.G1588S	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1588					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGCCCTCAGCCAGTGTGGGTA	0.493000													10	41					0	0	1	0	0
ABCD1	215	broad.mit.edu	37	X	152991603	152991603	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:152991603C>T	ENST00000218104.3	+	1	1281	c.882C>T	c.(880-882)gcC>gcT	p.A294A	ABCD1_ENST00000370129.4_Silent_p.A109A	NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	294	ABC transmembrane type-1.		A -> T (in X-ALD; AMN-type).		fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGATCGCCTTCTATGGGG	0.706000													2	1					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56392835	56392835	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56392835G>A	ENST00000301295.6	+	10	3289		c.e10-1		NLRP4_ENST00000587891.1_Splice_Site|NLRP4_ENST00000346986.5_Splice_Site	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4								ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TATTTTACCAGGCTGAGAAAA	0.413000													7	24					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80722519	80722519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80722519G>A	ENST00000458043.2	+	35	4253	c.4247G>A	c.(4246-4248)cGa>cAa	p.R1416Q	OTOGL_ENST00000547103.1_Missense_Mutation_p.R1416Q	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GTTTATCCACGAGACTGTAAG	0.378000													13	25					0	0	1	0	0
BIRC8	112401	broad.mit.edu	37	19	53792933	53792933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53792933C>T	ENST00000426466.1	-	1	1942	c.695G>A	c.(694-696)aGa>aAa	p.R232K		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	232					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		CATAAAAACTCTTTGCTTGAA	0.388000													15	160					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13901376	13901376	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13901376C>T	ENST00000265104.4	-	14	2141	c.2037G>A	c.(2035-2037)agG>agA	p.R679R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	679	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GAAGCCACGCCCTGTGGAAGA	0.478000									Kartagener syndrome				16	43					0	0	1	0	0
POLH	5429	broad.mit.edu	37	6	43550847	43550847	+	Missense_Mutation	SNP	C	C	T	rs113074920		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43550847C>T	ENST00000372236.4	+	3	536	c.241C>T	c.(241-243)Cgt>Tgt	p.R81C	POLH_ENST00000535400.1_Missense_Mutation_p.R19C|POLH_ENST00000372226.1_Missense_Mutation_p.R81C	NM_006502.2	NP_006493.1	Q9Y253	POLH_HUMAN	polymerase (DNA directed), eta	81	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			GGCACAAGTTCGTGAGTCCCG	0.413000								DNA polymerases (catalytic subunits)	Xeroderma Pigmentosum				17	46					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37707446	37707446	+	Silent	SNP	G	G	A	rs112589819		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37707446G>A	ENST00000539465.1	+	3	728	c.135G>A	c.(133-135)agG>agA	p.R45R	FRMPD1_ENST00000377765.3_Silent_p.R45R|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	45						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GGCCCGCCAGGAACCCAACTC	0.498000													28	70					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888670	38888670	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38888670C>T	ENST00000302328.3	-	26	5089	c.4891G>A	c.(4891-4893)Gaa>Aaa	p.E1631K	SCN11A_ENST00000456224.3_Missense_Mutation_p.E1593K|SCN11A_ENST00000450244.1_Missense_Mutation_p.E1631K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1631					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.E1631K(1)		NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCAAACTTTTCCCACACTTCA	0.408000													42	139					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1258188	1258188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1258188G>A	ENST00000447027.1	+	25	3158	c.3100G>A	c.(3100-3102)Gac>Aac	p.D1034N	MUC5B_ENST00000529681.1_Missense_Mutation_p.D1031N			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1031	VWFD 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GAACTTCGACGACAATGCCAT	0.672000													3	7					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113243788	113243788	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113243788C>T	ENST00000297405.5	-	69	11058	c.10814G>A	c.(10813-10815)gGc>gAc	p.G3605D	CSMD3_ENST00000455883.2_Missense_Mutation_p.G3436D|CSMD3_ENST00000343508.3_Missense_Mutation_p.G3565D|CSMD3_ENST00000352409.3_Missense_Mutation_p.G3535D	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3605						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCTTTGTAGGCCAAATTGTCC	0.328000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			28	130					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102585936	102585936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:102585936C>T	ENST00000251808.3	+	6	1113	c.775C>T	c.(775-777)Cgt>Tgt	p.R259C	GRHL2_ENST00000395927.1_Missense_Mutation_p.R243C	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	259						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			CAAATCTCTCCGTCAGAAGCA	0.507000													15	43					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5203915	5203915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5203915C>T	ENST00000334314.3	-	3	358	c.282G>A	c.(280-282)cgG>cgA	p.R94R						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						CCAATTCTGCCCGAAAGAAAG	0.393000													10	26					0	0	1	0	0
NT5DC2	64943	broad.mit.edu	37	3	52563345	52563345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52563345G>A	ENST00000307076.4	-	2	527	c.127C>T	c.(127-129)Ctg>Ttg	p.L43L	NT5DC2_ENST00000422318.2_Silent_p.L80L|NT5DC2_ENST00000307092.4_Silent_p.L9L|NT5DC2_ENST00000490681.1_5'UTR|NT5DC2_ENST00000459839.1_Silent_p.L80L	NM_022908.2	NP_075059.1	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2	43							hydrolase activity|metal ion binding			endometrium(1)|lung(3)|prostate(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		TCGGGGGGCAGGAGGTCTAGA	0.587000													7	37					0	0	1	0	0
ME3	10873	broad.mit.edu	37	11	86382822	86382822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:86382822C>T	ENST00000543262.1	-	2	491	c.165G>A	c.(163-165)agG>agA	p.R55R	ME3_ENST00000393324.3_Silent_p.R55R|ME3_ENST00000359636.2_Silent_p.R55R	NM_001161586.1	NP_001155058.1	Q16798	MAON_HUMAN	malic enzyme 3, NADP(+)-dependent, mitochondrial	55					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|skin(3)|stomach(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	GATGAGGGTTCCTGGTGACAT	0.682000													23	50					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14868871	14868871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14868871C>T	ENST00000380881.4	-	3	920	c.105G>A	c.(103-105)atG>atA	p.M35I	FREM1_ENST00000380880.3_Missense_Mutation_p.M35I|FREM1_ENST00000422223.2_Missense_Mutation_p.M35I			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	35					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGTGGCCCTTCATCACCCTCA	0.562000													7	11					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981484	70981484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70981484G>A	ENST00000276594.2	-	2	813	c.612C>T	c.(610-612)ttC>ttT	p.F204F		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CGTACAGAACGAAGTGCAGGT	0.602000													27	64					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12409257	12409257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12409257C>T	ENST00000358136.3	+	46	9387	c.9257C>T	c.(9256-9258)tCg>tTg	p.S3086L	VPS13D_ENST00000356315.4_Missense_Mutation_p.S3061L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3085					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCAGGGGATTCGTTTGCTGTG	0.502000													43	160					0	0	1	0	0
PAXIP1	22976	broad.mit.edu	37	7	154738116	154738116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:154738116G>A	ENST00000404141.1	-	20	3307	c.3153C>T	c.(3151-3153)ttC>ttT	p.F1051F	PAXIP1_ENST00000397192.1_Silent_p.F1051F|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	1051	BRCT 6.|Interaction with TP53BP1.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		CAGTCAGAACGAACTCTGCAT	0.433000													68	131					0	0	1	0	0
CCDC83	220047	broad.mit.edu	37	11	85606413	85606413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:85606413G>A	ENST00000280245.4	+	6	1101	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	CCDC83_ENST00000529676.2_3'UTR|CCDC83_ENST00000376067.1_Missense_Mutation_p.E98K|CCDC83_ENST00000342404.3_Missense_Mutation_p.E197K	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	197										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CCAAAAGAAGGAATGGGCCAC	0.284000													25	65					0	0	1	0	0
PRPSAP1	5635	broad.mit.edu	37	17	74326663	74326663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74326663G>A	ENST00000446526.3	-	5	993	c.548C>T	c.(547-549)tCa>tTa	p.S183L	PRPSAP1_ENST00000324684.4_Missense_Mutation_p.S80L	NM_002766.2	NP_002757.2	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 1	154					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17						CAGGAAAGGTGAGGCTCTAAG	0.388000													25	60					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16955967	16955967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:16955967G>A	ENST00000377833.4	-	48	7441	c.7376C>T	c.(7375-7377)tCt>tTt	p.S2459F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2459	CUB 18.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGTTCCAATAGAGCCCTGAAG	0.478000													29	75					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73152144	73152144	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:73152144C>T	ENST00000377110.2	-	25	4092	c.3849G>A	c.(3847-3849)tcG>tcA	p.S1283S	TRPM3_ENST00000396292.4_Silent_p.S1155S|TRPM3_ENST00000360823.2_Silent_p.S1145S|TRPM3_ENST00000423814.3_Silent_p.S1310S|TRPM3_ENST00000396285.1_Silent_p.S1142S|TRPM3_ENST00000358082.3_Silent_p.S1145S|TRPM3_ENST00000357533.2_Silent_p.S1287S|TRPM3_ENST00000377105.1_Silent_p.S1142S|TRPM3_ENST00000377106.1_Silent_p.S1155S|TRPM3_ENST00000396280.5_Silent_p.S1132S|TRPM3_ENST00000377111.2_Silent_p.S1283S|TRPM3_ENST00000408909.2_Silent_p.S1142S	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1308						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						ACGAGGTCCTCGAGCGGATTT	0.612000													33	64					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39879654	39879654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39879654C>T	ENST00000260356.5	+	8	1392	c.1227C>T	c.(1225-1227)ctC>ctT	p.L409L		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	409	TSP type-1 1.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GCGATAGCCTCAACAACCGAT	0.577000													8	32					0	0	1	0	0
ITFG3	83986	broad.mit.edu	37	16	314141	314141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:314141C>T	ENST00000399932.3	+	11	1766	c.1315C>T	c.(1315-1317)Ctc>Ttc	p.L439F	ITFG3_ENST00000301679.2_Missense_Mutation_p.L439F|ITFG3_ENST00000442458.2_Missense_Mutation_p.L439F|ITFG3_ENST00000301678.3_Missense_Mutation_p.L439F|ITFG3_ENST00000450082.2_Missense_Mutation_p.L439F|ITFG3_ENST00000600536.1_Missense_Mutation_p.L439F			Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	439						integral to membrane				central_nervous_system(3)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				CTTCTGGGGCCTCCACGAGCT	0.701000													4	19					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64222206	64222206	+	Missense_Mutation	SNP	C	C	T	rs138448367	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64222206C>T	ENST00000205948.6	-	3	315	c.278G>A	c.(277-279)gGa>gAa	p.G93E		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	93	Sushi 2.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			GCGTACGGCTCCATTTTCTAA	0.358000													17	58					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25043497	25043497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:25043497C>T	ENST00000216336.2	-	4	584	c.548G>A	c.(547-549)aGg>aAg	p.R183K		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	183	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		ACAAATCTGCCTTCGGGGGTC	0.622000													16	31					0	0	1	0	0
MARCH11	441061	broad.mit.edu	37	5	16067687	16067687	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:16067687G>A	ENST00000332432.8	-	4	1301	c.1102C>T	c.(1102-1104)Cag>Tag	p.Q368*		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	368						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						TAGCCACACTGAAACCTTGGT	0.498000													47	130					0	0	1	0	0
ZNF133	7692	broad.mit.edu	37	20	18295752	18295752	+	Missense_Mutation	SNP	C	C	T	rs140722849		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:18295752C>T	ENST00000377671.3	+	7	813	c.254C>T	c.(253-255)cCt>cTt	p.P85L	ZNF133_ENST00000462170.1_3'UTR|ZNF133_ENST00000396026.3_Missense_Mutation_p.P89L|RP4-568F9.3_ENST00000436848.1_RNA|ZNF133_ENST00000316358.4_Missense_Mutation_p.P86L|ZNF133_ENST00000402618.2_Missense_Mutation_p.P23L|ZNF133_ENST00000538547.1_5'UTR|ZNF133_ENST00000535822.1_5'UTR|ZNF133_ENST00000401790.1_Missense_Mutation_p.P86L	NM_001083330.1|NM_003434.4	NP_001076799.1|NP_003425.2	P52736	ZN133_HUMAN	zinc finger protein 133	86						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						CCTTTCTGCCCTCCGGGTTTC	0.527000													28	115					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94711930	94711930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94711930G>A	ENST00000304338.3	+	13	1505	c.1351G>A	c.(1351-1353)Gat>Aat	p.D451N		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	451						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AAAGGTACTAGATGCTCTTAT	0.308000													23	66					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201356012	201356012	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201356012C>T	ENST00000391967.2	-	3	778	c.477G>A	c.(475-477)gaG>gaA	p.E159E	LAD1_ENST00000367313.3_Silent_p.E173E	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	159						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						CCACCAAGCTCTCCTCCTCCA	0.587000													21	116					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544596	82544596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82544596G>A	ENST00000423517.2	-	7	13043	c.12706C>T	c.(12706-12708)Ctc>Ttc	p.L4236F	PCLO_ENST00000437081.1_Missense_Mutation_p.L956F|PCLO_ENST00000333891.8_Missense_Mutation_p.L4236F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4167	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTTGAAGGAGCCTTGCCCTG	0.398000													13	41					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50461685	50461685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50461685G>A	ENST00000447370.2	-	8	1596	c.1506C>T	c.(1504-1506)tcC>tcT	p.S502S	SIGLEC11_ENST00000426971.2_Intron	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	502					cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		TGACCTCGAAGGAGCCCTGAC	0.697000													4	18					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40710658	40710658	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40710658C>T	ENST00000373198.3	-	31	4438		c.e31-1		PTPRT_ENST00000373187.1_Splice_Site|PTPRT_ENST00000373193.3_Splice_Site|PTPRT_ENST00000373201.1_Splice_Site|PTPRT_ENST00000373184.1_Splice_Site|PTPRT_ENST00000356100.2_Splice_Site|PTPRT_ENST00000373190.1_Splice_Site	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T						homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCCCCCATTTCTAAACACAGA	0.498000													20	75					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167051693	167051693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167051693C>T	ENST00000392766.2	-	10	949	c.609G>A	c.(607-609)gaG>gaA	p.E203E	ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Silent_p.E174E|ZBBX_ENST00000455345.2_Silent_p.E203E|ZBBX_ENST00000392767.2_Silent_p.E203E|ZBBX_ENST00000307529.5_Silent_p.E203E	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	203						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AATTATTCTCCTCTTTGGGTT	0.328000													19	57					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140616020	140616020	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140616020G>A	ENST00000526308.1	+	0	2083					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						GCTGCTGAGCGAGCGCGACGC	0.711000													35	89					0	0	1	0	0
WDR13	64743	broad.mit.edu	37	X	48458948	48458948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48458948C>T	ENST00000218056.5	+	5	1270	c.765C>T	c.(763-765)atC>atT	p.I255I		NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	255						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						TCCGAGAGATCCCTGACCCCG	0.597000													10	8					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37153991	37153991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:37153991G>A	ENST00000274258.7	-	41	8343	c.4756C>T	c.(4756-4758)Cct>Tct	p.P1586S	C5orf42_ENST00000508244.1_Missense_Mutation_p.P2688S|C5orf42_ENST00000425232.2_Missense_Mutation_p.P2688S			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2688										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CTTGGTGCAGGGCAAGCTGCA	0.468000													17	79					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149901663	149901663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149901663G>A	ENST00000439741.2	-	16	2043	c.1793C>T	c.(1792-1794)tCc>tTc	p.S598F	MTMR11_ENST00000406732.3_3'UTR|MTMR11_ENST00000369140.3_Missense_Mutation_p.S526F|MTMR11_ENST00000361405.6_3'UTR|MTMR11_ENST00000492824.1_5'UTR	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	598	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GCTTTCAGAGGAGATAGCAGG	0.602000													25	74					0	0	1	0	0
IL26	55801	broad.mit.edu	37	12	68619438	68619438	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:68619438G>T	ENST00000229134.4	-	1	163	c.99C>A	c.(97-99)taC>taA	p.Y33*	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	33					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTCCCCTTGGGTAACAACTTT	0.433000													23	222					5.45024e-15	5.47859e-15	1	1	0
GRXCR2	643226	broad.mit.edu	37	5	145246165	145246165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145246165C>T	ENST00000377976.1	-	2	462	c.463G>A	c.(463-465)Gag>Aag	p.E155K		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	155										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						ATCAGAGACTCTTCCTCAGCC	0.443000													52	122					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43414954	43414954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43414954C>T	ENST00000187910.2	-	3	549	c.484G>A	c.(484-486)Gag>Aag	p.E162K	PSG6_ENST00000292125.2_Missense_Mutation_p.E162K|PSG6_ENST00000402603.4_Missense_Mutation_p.E162K	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				CGCACAGCCTCCATGACCTCC	0.542000													58	256					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17446091	17446091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:17446091C>T	ENST00000262545.2	+	11	1638	c.1323C>T	c.(1321-1323)ctC>ctT	p.L441L	PCSK2_ENST00000536609.1_Silent_p.L406L|PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000377899.1_Silent_p.L422L	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	441					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTAATCACCTCTTTGGCTACG	0.557000													16	40					0	0	1	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31692252	31692252	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31692252C>T	ENST00000360542.3	-	1	355	c.102G>A	c.(100-102)gtG>gtA	p.V34V		NM_203405.1	NP_981950.1	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	34						intermediate filament				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16						CTCCACAGCTCACGCTGGTAG	0.557000													38	91					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70917960	70917960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70917960G>A	ENST00000264436.3	-	8	1251	c.807C>T	c.(805-807)gcC>gcT	p.A269A	ADD2_ENST00000413157.2_Silent_p.A269A|ADD2_ENST00000407644.2_Silent_p.A269A|ADD2_ENST00000355733.3_Silent_p.A269A|AC007395.3_ENST00000457851.1_RNA|ADD2_ENST00000430656.1_Silent_p.A285A	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	269					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						TGATCCGATCGGCTTCCTGCT	0.532000													24	81					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42490089	42490089	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42490089C>T	ENST00000545399.1	-	6	725	c.572G>A	c.(571-573)gGg>gAg	p.G191E	ATP1A3_ENST00000302102.5_Missense_Mutation_p.G178E|ATP1A3_ENST00000602133.1_Missense_Mutation_p.G148E|ATP1A3_ENST00000543770.1_Missense_Mutation_p.G189E	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	178					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CACCAGGTCCCCGACCACCAC	0.627000													42	128					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184099561	184099561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184099561C>T	ENST00000204604.1	+	5	815	c.569C>T	c.(568-570)tCg>tTg	p.S190L	EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000482805.1_3'UTR|CHRD_ENST00000348986.3_Missense_Mutation_p.S190L|CHRD_ENST00000450923.1_Missense_Mutation_p.S190L	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	190	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCCGAGTCTCGCTGCTGCGC	0.662000													13	17					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466553	56466553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56466553G>A	ENST00000291971.3	+	3	1200	c.1129G>A	c.(1129-1131)Gac>Aac	p.D377N	NLRP8_ENST00000590542.1_Missense_Mutation_p.D377N	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	377	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AGAGGAGGGAGACCAAGTCTT	0.478000													27	103					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14775943	14775943	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14775943G>A	ENST00000380881.4	-	26	5519	c.4704C>T	c.(4702-4704)ttC>ttT	p.F1568F	FREM1_ENST00000380894.1_Silent_p.F103F|FREM1_ENST00000380880.3_Silent_p.F1567F|FREM1_ENST00000422223.2_Silent_p.F1567F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1567					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCTGCTGGGTGAAATTGTGTT	0.557000													13	122					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55614818	55614818	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55614818G>A	ENST00000326258.1	+	1	10	c.10G>A	c.(10-12)Gaa>Aaa	p.E4K		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						TATGATCTGTGAAAATCACAC	0.313000													28	168					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505396	159505396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159505396G>A	ENST00000334857.2	-	1	446	c.402C>T	c.(400-402)gtC>gtT	p.V134V		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					TGCTCATGATGACAGTGTATC	0.483000													38	83					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120598020	120598020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120598020G>A	ENST00000300648.6	-	23	2488	c.2476C>T	c.(2476-2478)Ctg>Ttg	p.L826L		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	826					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTGCTGGTCAGCTGCACCTCC	0.582000													25	81					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468546	56468546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56468546C>T	ENST00000312153.1	+	1	683	c.683C>T	c.(682-684)tCc>tTc	p.S228F		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						TTGAGGATCTCCTCCTCCAAG	0.512000													42	214					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60708742	60708742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60708742G>A	ENST00000227880.3	-	5	1361	c.1128C>T	c.(1126-1128)ctC>ctT	p.L376L		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	376					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						CATTGGCCAGGAGGAGCCAGG	0.597000													11	26					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9264799	9264799	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9264799G>A	ENST00000318602.7	-	4	746	c.439C>T	c.(439-441)Cgt>Tgt	p.R147C		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	147					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GAGACAACACGAAATTTCACT	0.393000													10	49					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72290353	72290353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72290353G>A	ENST00000334456.5	-	27	2576	c.2331C>T	c.(2329-2331)ttC>ttT	p.F777F	PDE2A_ENST00000540345.1_Silent_p.F768F|PDE2A_ENST00000418754.2_Silent_p.F662F|PDE2A_ENST00000444035.2_Silent_p.F768F|PDE2A_ENST00000544570.1_Silent_p.F770F|PDE2A_ENST00000376450.3_Silent_p.F521F	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	777	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GGAGGTCCTTGAAGATGCGGA	0.602000													43	78					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656741	19656741	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19656741C>T	ENST00000586018.1	+	8	3507	c.3405C>T	c.(3403-3405)atC>atT	p.I1135I	CILP2_ENST00000291495.4_Silent_p.I1129I			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1129						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						TTGGTGACATCCGCAGGGAGA	0.731000													4	17					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50294041	50294041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50294041G>A	ENST00000332853.3	-	3	508	c.485C>T	c.(484-486)tCa>tTa	p.S162L		NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	162						integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						CTCAAAGGATGACTCTTCAGA	0.318000													12	61					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	705079	705079	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:705079C>T	ENST00000549091.1	+	14	1580	c.1488C>T	c.(1486-1488)gtC>gtT	p.V496V	WDR90_ENST00000293879.4_Silent_p.V496V|LA16c-349E10.1_ENST00000573609.1_RNA	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	496										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GCGAGGTGGTCGTTCTGGCAA	0.652000													13	70					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2786312	2786312	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2786312C>T	ENST00000399655.1	+	40	5146	c.4881C>T	c.(4879-4881)taC>taT	p.Y1627Y	CACNA1C_ENST00000347598.4_Silent_p.Y1675Y|CACNA1C_ENST00000399591.1_Silent_p.Y1635Y|CACNA1C_ENST00000344100.3_Silent_p.Y1668Y|CACNA1C_ENST00000399597.1_Silent_p.Y1627Y|CACNA1C_ENST00000335762.5_Silent_p.Y1652Y|CACNA1C_ENST00000399595.1_Silent_p.Y1635Y|CACNA1C_ENST00000399603.1_Silent_p.Y1627Y|CACNA1C_ENST00000399617.1_Silent_p.Y1627Y|CACNA1C_ENST00000399606.1_Silent_p.Y1647Y|CACNA1C_ENST00000399621.1_Silent_p.Y1646Y|CACNA1C_ENST00000399601.1_Silent_p.Y1627Y|CACNA1C_ENST00000399638.1_Silent_p.Y1655Y|CACNA1C_ENST00000399649.1_Silent_p.Y1633Y|CACNA1C_ENST00000399644.1_Silent_p.Y1627Y|CACNA1C_ENST00000399629.1_Silent_p.Y1644Y|CACNA1C_ENST00000327702.7_Silent_p.Y1627Y|CACNA1C_ENST00000399634.1_Silent_p.Y1627Y|CACNA1C_ENST00000399637.1_Silent_p.Y1646Y|CACNA1C_ENST00000406454.3_Silent_p.Y1627Y|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000402845.3_Silent_p.Y1646Y|CACNA1C_ENST00000399641.1_Silent_p.Y1627Y	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1675					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity	p.Y1675*(1)|p.Y1705*(1)|p.Y1162*(1)|p.Y1668*(1)|p.Y1627*(1)		NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCCAGGAGTACTTCCGGAAGT	0.607000													11	22					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34247714	34247714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:34247714G>A	ENST00000346562.2	+	8	1067	c.993G>A	c.(991-993)ggG>ggA	p.G331G	NPAS3_ENST00000357798.5_Silent_p.G350G|NPAS3_ENST00000548645.1_Silent_p.G333G|NPAS3_ENST00000356141.4_Silent_p.G363G|NPAS3_ENST00000551492.1_Silent_p.G368G	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	363	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		ATATCGTAGGGAAGAGATGCT	0.468000													30	67					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107979432	107979432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107979432G>A	ENST00000372129.2	-	1	219	c.143C>T	c.(142-144)tCg>tTg	p.S48L		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	48						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CGGACAAGACGACCCGGTCCC	0.657000													15	18					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569894	241569894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241569894C>T	ENST00000319838.5	+	6	1467	c.525C>T	c.(523-525)ttC>ttT	p.F175F	GPR35_ENST00000430267.1_Silent_p.F175F|GPR35_ENST00000407714.1_Silent_p.F175F|GPR35_ENST00000403859.1_Silent_p.F175F|GPR35_ENST00000438013.2_Silent_p.F206F	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	175						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		CCATGGCGTTCCCGCTGCTGG	0.657000													16	72					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545156	186545156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186545156G>A	ENST00000431808.1	-	14	1978	c.1415C>T	c.(1414-1416)tCc>tTc	p.S472F	SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.S572F|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.S376F|SORBS2_ENST00000284776.7_Missense_Mutation_p.S472F			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	472						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GGACTTCACGGAGCAGATCAC	0.607000													32	83					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74542148	74542148	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74542148C>T	ENST00000394019.2	-	6	400	c.3G>A	c.(1-3)atG>atA	p.M1I	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000359484.4_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000358683.4_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000357822.5_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000346834.4_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000377634.4_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000377632.1_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000423644.1_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000483195.1_Intron	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CCTTCACCTTCATGACTATAA	0.428000													66	156					0	0	1	0	0
NSUN4	387338	broad.mit.edu	37	1	46810805	46810805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46810805C>T	ENST00000474844.1	+	2	1076	c.426C>T	c.(424-426)ttC>ttT	p.F142F	NSUN4_ENST00000536062.1_Silent_p.F93F|NSUN4_ENST00000537428.1_Silent_p.F93F|NSUN4_ENST00000498008.1_3'UTR	NM_199044.3	NP_950245.2	Q96CB9	NSUN4_HUMAN	NOP2/Sun domain family, member 4	142							methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	8	Acute lymphoblastic leukemia(166;0.155)					TCAGTCGCTTCCCTCCTGCCA	0.562000													23	48					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74004825	74004825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74004825C>T	ENST00000301607.3	-	22	4714	c.4461G>A	c.(4459-4461)caG>caA	p.Q1487Q	EVPL_ENST00000586740.1_Silent_p.Q1509Q	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1487	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GGGTCTTCTCCTGGTCCAGGT	0.572000													62	120					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72492920	72492920	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72492920G>A	ENST00000319622.6	-	10	1840	c.1384C>T	c.(1384-1386)Cag>Tag	p.Q462*	PKM_ENST00000389093.3_Nonsense_Mutation_p.Q462*|PKM_ENST00000568883.1_Nonsense_Mutation_p.Q297*|PKM_ENST00000568459.1_Nonsense_Mutation_p.Q462*|PKM_ENST00000335181.5_Nonsense_Mutation_p.Q462*|PKM_ENST00000565154.1_Nonsense_Mutation_p.Q462*|PKM_ENST00000565184.1_Nonsense_Mutation_p.Q462*|PKM_ENST00000449901.2_Nonsense_Mutation_p.Q447*	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						AGGTGGGCCTGACGAGCTGTC	0.617000													9	109					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29562632	29562632	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:29562632G>T	ENST00000358273.4	+	28	4095	c.3712G>T	c.(3712-3714)Gaa>Taa	p.E1238*	NF1_ENST00000356175.3_Nonsense_Mutation_p.E1238*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1238	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTCTCAGGATGAACTAGCTCG	0.378000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			84	131					4.02937e-33	4.05745e-33	1	1	0
GIMAP8	155038	broad.mit.edu	37	7	150163999	150163999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150163999C>T	ENST00000307271.3	+	2	787	c.213C>T	c.(211-213)tcC>tcT	p.S71S		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	71						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ACCTTTTCTCCTCAATAGCTT	0.502000													68	140					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92560267	92560267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:92560267C>T	ENST00000377067.3	+	6	1729	c.1357C>T	c.(1357-1359)Cct>Tct	p.P453S		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	453						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AGGAATTGATCCTGTGATAAA	0.353000													16	63					0	0	1	0	0
ZNF174	7727	broad.mit.edu	37	16	3454458	3454458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3454458C>T	ENST00000268655.4	+	2	1020	c.435C>T	c.(433-435)ctC>ctT	p.L145L	ZNF174_ENST00000344823.5_Silent_p.L145L|ZNF174_ENST00000571936.1_Silent_p.L145L|ZNF174_ENST00000572544.1_Silent_p.L145L|ZNF174_ENST00000575752.1_Silent_p.L145L|LA16c-306E5.2_ENST00000575785.1_RNA	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	145					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						AAAAGGTGCTCTTGGAGAAAA	0.512000													58	107					0	0	1	0	0
FAM181A	90050	broad.mit.edu	37	14	94395108	94395108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94395108C>T	ENST00000267594.5	+	3	970	c.663C>T	c.(661-663)ccC>ccT	p.P221P	FAM181A_ENST00000557000.2_Silent_p.P159P|FAM181A_ENST00000557719.1_Silent_p.P159P|FAM181A_ENST00000556222.1_Silent_p.P159P	NM_001207073.1|NM_001207074.1|NM_138344.4	NP_001194002.1|NP_001194003.1|NP_612353.3	Q8N9Y4	F181A_HUMAN	family with sequence similarity 181, member A	221										cervix(1)|endometrium(2)|large_intestine(8)|lung(4)|prostate(1)|skin(2)	18						GACTGGGCCCCAGGGAGGGAC	0.627000													15	35					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37319368	37319368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37319368C>T	ENST00000262825.5	+	3	376	c.159C>T	c.(157-159)gcC>gcT	p.A53A	CSF2RB_ENST00000406230.1_Silent_p.A53A|CSF2RB_ENST00000403662.3_Silent_p.A53A	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	53					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CCCAGGATGCCCAGCGGCTCG	0.637000													11	41					0	0	1	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151205035	151205035	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151205035C>T	ENST00000409426.1	+	6	904	c.459C>T	c.(457-459)ctC>ctT	p.L153L	PIP5K1A_ENST00000441902.2_Silent_p.L153L|PIP5K1A_ENST00000368888.4_Silent_p.L165L|PIP5K1A_ENST00000368890.4_Silent_p.L152L			Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	165	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			breast(1)|central_nervous_system(1)|ovary(1)|skin(1)|stomach(1)	5	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGTATTCCCTCTGCAGTGAGC	0.428000													28	49					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79579761	79579761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:79579761G>A	ENST00000372391.2	-	16	3423	c.3418C>T	c.(3418-3420)Ccg>Tcg	p.P1140S	DLG5_ENST00000372388.2_Missense_Mutation_p.P800S|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1140					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CCACTGGCCGGGACACACTTC	0.607000													19	76					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117853292	117853292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117853292C>T	ENST00000350763.4	-	2	417	c.6G>A	c.(4-6)ggG>ggA	p.G2G	TNC_ENST00000535648.1_Silent_p.G2G|TNC_ENST00000542877.1_Silent_p.G2G|TNC_ENST00000423613.2_Silent_p.G2G|TNC_ENST00000346706.3_Silent_p.G2G|TNC_ENST00000537320.1_Silent_p.G2G|TNC_ENST00000341037.4_Silent_p.G2G|TNC_ENST00000345230.3_Silent_p.G2G|TNC_ENST00000340094.3_Silent_p.G2G	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2					cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GAGTCATGGCCCCCATGGTGG	0.557000													21	18					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50500108	50500108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50500108C>T	ENST00000301149.3	+	4	630	c.398C>T	c.(397-399)tCg>tTg	p.S133L	GPD1_ENST00000547190.1_3'UTR|GPD1_ENST00000548814.1_Missense_Mutation_p.S110L	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	133					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	AAGCTCATCTCGGAAGTGATT	0.617000													13	18					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818883	159818883	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159818883G>A	ENST00000497452.1	-	0	517																											ggagaaaacggagaagagtta	0.463000													116	369					0	0	1	0	0
ZNF525	170958	broad.mit.edu	37	19	53885197	53885197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53885197C>T	ENST00000467003.1	+	4	1458	c.1257C>T	c.(1255-1257)acC>acT	p.T419T	ZNF525_ENST00000593918.1_Intron|ZNF525_ENST00000475179.1_Intron|ZNF525_ENST00000474037.1_Silent_p.T455T|ZNF525_ENST00000355326.3_Silent_p.T173T					zinc finger protein 525											endometrium(3)|kidney(3)|lung(3)	9						TATCCCTTACCTGCCATTGTA	0.378000													21	39					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53413730	53413730	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53413730G>A	ENST00000371514.3	+	3	345	c.177G>A	c.(175-177)caG>caA	p.Q59Q	SCP2_ENST00000407246.2_Intron|SCP2_ENST00000371513.5_Silent_p.Q59Q|SCP2_ENST00000371509.4_Silent_p.Q59Q|SCP2_ENST00000528311.1_5'UTR	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	59					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						CAGTGGACCAGGCATGTGTTG	0.348000													46	178					0	0	1	0	0
BTNL3	10917	broad.mit.edu	37	5	180432565	180432565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180432565G>A	ENST00000342868.6	+	8	1278	c.1094G>A	c.(1093-1095)gGg>gAg	p.G365E		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	365	B30.2/SPRY.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GTAGACAGGGGGAAGAACAAT	0.478000													18	60					0	0	1	0	0
IGKJ5	28946	broad.mit.edu	37	2	89160099	89160099	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89160099C>T	ENST00000452230.1	-	0	39				IGKJ5_ENST00000390238.2_RNA|AC096579.7_ENST00000430694.1_RNA																							CCAGTCGTGTCCCTTGGCCGA	0.383000													23	54					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187153312	187153312	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187153312C>A	ENST00000264690.6	+	3	277	c.90C>A	c.(88-90)ttC>ttA	p.F30L	KLKB1_ENST00000513864.1_Missense_Mutation_p.F30L	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	30	Apple 1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		AAAACGCCTTCTTCAGAGGTG	0.383000													50	117					3.28156e-27	3.30318e-27	1	1	0
EPHA3	2042	broad.mit.edu	37	3	89448644	89448644	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:89448644C>T	ENST00000452448.2	+	7	1695	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	EPHA3_ENST00000336596.2_Intron|EPHA3_ENST00000494014.1_Intron	NM_182644.2	NP_872585.1	P29320	EPHA3_HUMAN	EPH receptor A3	0						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGTATTATTTCAATGCAGTCT	0.408000										TSP Lung(6;0.00050)			16	37					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179529435	179529435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179529435C>T	ENST00000589042.1	-	167	36372	c.36148G>A	c.(36148-36150)Gaa>Aaa	p.E12050K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10198	Ig-like 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTTCTTTTCAGGGACAATT	0.383000													12	46					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814408	106814408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106814408G>A	ENST00000407775.2	+	8	2348	c.2098G>A	c.(2098-2100)Gaa>Aaa	p.E700K	ZFPM2_ENST00000520492.1_Missense_Mutation_p.E568K|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.E431K|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.E568K|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	700					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CAGCCGGCACGAAACATACAT	0.488000													13	27					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189864087	189864087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189864087C>T	ENST00000304636.3	+	30	2269	c.2099C>T	c.(2098-2100)cCc>cTc	p.P700L	COL3A1_ENST00000317840.5_Missense_Mutation_p.P700L	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	700	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGAGCTGGTCCCCCTGGTCCC	0.473000													4	17					0	0	1	0	0
RPL18	6141	broad.mit.edu	37	19	49119388	49119388	+	Silent	SNP	G	G	A	rs138053229	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49119388G>A	ENST00000549273.1	-	5	402	c.369C>T	c.(367-369)ttC>ttT	p.F123F	RPL18_ENST00000549920.1_Silent_p.F123F|RPL18_ENST00000552588.1_Silent_p.F94F|RPL18_ENST00000550645.1_Intron			Q07020	RL18_HUMAN	ribosomal protein L18	123					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			cervix(1)|kidney(2)	3		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)		CCAGCTGGTCGAAAGTGAGGA	0.642000													20	54					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409973	105409973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105409973C>T	ENST00000333244.5	-	7	11934	c.11815G>A	c.(11815-11817)Gag>Aag	p.E3939K	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3939						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTGGGGCCTCGACGTCCACC	0.597000													90	288					0	0	1	0	0
IFI27L2	83982	broad.mit.edu	37	14	94594942	94594942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94594942G>A	ENST00000556727.1	-	3	260	c.33C>T	c.(31-33)tcC>tcT	p.S11S	IFI27L2_ENST00000238609.3_Silent_p.S36S			Q9H2X8	I27L2_HUMAN	interferon, alpha-inducible protein 27-like 2	36						integral to membrane		p.S36S(1)		breast(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	8						CTGCTATGGAGGACGCGGCGA	0.637000													4	51					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3679789	3679789	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3679789G>A	ENST00000294600.2	+	7	1156	c.1072G>A	c.(1072-1074)Ggt>Agt	p.G358S		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	358	Glu-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TGCCTGGGGAGGTGTGAGCCA	0.672000													5	5					0	0	1	0	0
KCNK15	60598	broad.mit.edu	37	20	43379197	43379197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43379197C>T	ENST00000372861.3	+	2	842	c.711C>T	c.(709-711)gcC>gcT	p.A237A		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	237						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				TCATTGGCGCCTTCCTCAACC	0.706000													15	83					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152193650	152193650	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152193650G>A	ENST00000368801.2	-	3	530	c.455C>T	c.(454-456)aCt>aTt	p.T152I	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	152					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TATGGATTCAGTCCCAGGTTT	0.438000													10	125					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12341345	12341345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12341345C>T	ENST00000256186.2	+	4	1820	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	510					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		CCCCAGCTTTCCTTGCAGTTA	0.517000													42	98					0	0	1	0	0
TFG	10342	broad.mit.edu	37	3	100467173	100467173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100467173C>T	ENST00000240851.4	+	8	1341	c.1001C>T	c.(1000-1002)tCt>tTt	p.S334F	TFG_ENST00000418917.2_Missense_Mutation_p.S330F|TFG_ENST00000481203.1_3'UTR|TFG_ENST00000476228.1_Missense_Mutation_p.S330F|TFG_ENST00000490574.1_Missense_Mutation_p.S334F	NM_001195478.1|NM_001195479.1|NM_006070.5	NP_001182407.1|NP_001182408.1|NP_006061.2	Q92734	TFG_HUMAN	TRK-fused gene	334					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/NR4A3(2)|TFG/NTRK1_ENST00000392302(5)|TFG/ALK(9)	large_intestine(4)|lung(2)|prostate(1)|stomach(1)	8						GCCCAAACTTCTCAGCCTACT	0.522000			T	"""NTRK1, ALK"""	"""papillary thyroid, ALCL, NSCLC"""								34	109					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125805353	125805353	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:125805353C>T	ENST00000346248.5	-	2	1018	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	CHST15_ENST00000421115.1_Missense_Mutation_p.E126K|CHST15_ENST00000435907.1_Missense_Mutation_p.E126K	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	126					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	p.E126K(1)		endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						CTTGGGTTTTCGCTGTCCATC	0.438000													82	178					0	0	1	0	0
MYF6	4618	broad.mit.edu	37	12	81101534	81101534	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81101534C>T	ENST00000228641.3	+	1	258	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	12					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						GCTCCTATTTCTTCTACTTGG	0.493000													36	88					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5860039	5860039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5860039G>A	ENST00000546188.1	-	11	1215	c.1144C>T	c.(1144-1146)Ctt>Ttt	p.L382F	ANO2_ENST00000356134.5_Missense_Mutation_p.L382F|ANO2_ENST00000327087.8_Missense_Mutation_p.L381F			Q9NQ90	ANO2_HUMAN	anoctamin 2	386						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CATCCATAAAGAAACACAATC	0.353000													10	21					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183778095	183778095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183778095C>T	ENST00000318351.1	+	9	1333	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	433						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ACCTGCTCTTCATGGCCTCCT	0.567000													66	175					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68992794	68992794	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68992794G>A	ENST00000288368.4	+	16	2036	c.1759G>A	c.(1759-1761)Gaa>Aaa	p.E587K	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	587					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AAAAGTTGTGGAAAATGTTAT	0.318000													4	44					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179587780	179587780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179587780G>A	ENST00000444136.1	+	5	1128	c.878G>A	c.(877-879)gGa>gAa	p.G293E	TDRD5_ENST00000367614.1_Missense_Mutation_p.G293E|TDRD5_ENST00000294848.8_Missense_Mutation_p.G293E	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	293					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GGACCTGGAGGAACTATCAGT	0.313000													30	83					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36291092	36291092	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36291092G>C	ENST00000301175.3	-	11	1476	c.1459C>G	c.(1459-1461)Ccc>Gcc	p.P487A		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	487					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGCCATAGGGAATGGACTTA	0.557000													4	8					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100361804	100361804	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100361804G>A	ENST00000542585.1	+	0	4400				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCCCTGGAGGGAACCCCACTT	0.617000													4	14					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94488981	94488981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:94488981G>A	ENST00000375708.3	-	8	1426	c.1228C>T	c.(1228-1230)Ccc>Tcc	p.P410S	ROR2_ENST00000375715.1_Missense_Mutation_p.P270S|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	410					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GCGATGCTGGGGACCAAGATG	0.498000													29	50					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40362893	40362893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40362893G>A	ENST00000221347.6	-	32	15184	c.15177C>T	c.(15175-15177)ccC>ccT	p.P5059P		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5059	VWFD 12.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGGTCGCGAAGGGGCCCTGGG	0.652000													49	118					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56538970	56538970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56538970G>A	ENST00000390649.3	+	7	1371	c.1371G>A	c.(1369-1371)gcG>gcA	p.A457A		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	457	NACHT.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GGTTGCGTGCGATCATGAACA	0.597000													9	27					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101194818	101194818	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:101194818G>A	ENST00000294728.2	+	5	1185	c.1084G>A	c.(1084-1086)Gag>Aag	p.E362K	VCAM1_ENST00000347652.2_Intron|VCAM1_ENST00000370115.1_Intron|VCAM1_ENST00000370119.4_Missense_Mutation_p.E300K	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	362	Ig-like C2-type 4.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GGTGAGGAGTGAGGGGACCAA	0.507000													56	125					0	0	1	0	0
KLK3	354	broad.mit.edu	37	19	51361366	51361366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51361366C>T	ENST00000360617.3	+	3	288	c.288C>T	c.(286-288)ttC>ttT	p.F96F	KLK3_ENST00000326003.2_Silent_p.F96F|KLK3_ENST00000593997.1_Silent_p.F96F|KLK3_ENST00000597483.1_Intron|KLK3_ENST00000595952.1_Intron			P07288	KLK3_HUMAN	kallikrein-related peptidase 3	96	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		GCCACAGCTTCCCACACCCGC	0.577000													23	47					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140793597	140793597	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140793597C>T	ENST00000398610.2	+	1	855	c.855C>T	c.(853-855)ttC>ttT	p.F285F	PCDHGA8_ENST00000398604.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATATTCATTCCGAAAATTAC	0.418000													8	13					0	0	1	0	0
PRRT2	112476	broad.mit.edu	37	16	29824999	29824999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29824999C>T	ENST00000300797.6	+	2	798	c.624C>T	c.(622-624)tcC>tcT	p.S208S	PRRT2_ENST00000567659.1_Silent_p.S208S|AC009133.20_ENST00000569039.1_RNA|PRRT2_ENST00000358758.7_Silent_p.S208S|PRRT2_ENST00000567551.1_Intron			Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	208	Pro-rich.				response to biotic stimulus	integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						CAAAAAAATCCCCCCCAGCCA	0.622000													3	11					0	0	1	0	0
SART3	9733	broad.mit.edu	37	12	108919251	108919251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108919251G>A	ENST00000228284.3	-	17	2740	c.2506C>T	c.(2506-2508)Cgg>Tgg	p.R836W	FICD_ENST00000546448.1_Intron|SART3_ENST00000431469.2_Missense_Mutation_p.R800W	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	836	RRM 2.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						TTGCCAGCCCGGTTGGTGACC	0.493000									Porokeratosis				23	46					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35803183	35803183	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35803183G>A	ENST00000361922.4	+	11	1866		c.e11-1		MAG_ENST00000392213.3_Intron|MAG_ENST00000537831.2_Intron	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein						blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTCTCCAATAGTCCAAAGAGG	0.642000													32	133					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55566490	55566490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55566490C>T	ENST00000373965.2	-	36	5298	c.4904G>A	c.(4903-4905)aGg>aAg	p.R1635K	PCDH15_ENST00000414778.1_Missense_Mutation_p.R1632K	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTTTTCAGCCTGTTCCTTAG	0.448000										HNSCC(58;0.16)			97	225					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46825081	46825081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46825081G>A	ENST00000339613.2	+	10	1280	c.1025G>A	c.(1024-1026)aGc>aAc	p.S342N	AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000300862.3_Missense_Mutation_p.S396N|HIF3A_ENST00000244303.6_Missense_Mutation_p.S329N|HIF3A_ENST00000420102.2_Missense_Mutation_p.S347N|HIF3A_ENST00000377670.4_Missense_Mutation_p.S398N|HIF3A_ENST00000472815.1_Missense_Mutation_p.S329N|HIF3A_ENST00000600383.1_Missense_Mutation_p.S329N			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CCTTCCCTGAGCGAGGCTGCC	0.682000													21	93					0	0	1	0	0
CRYGC	1420	broad.mit.edu	37	2	208993030	208993030	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:208993030C>T	ENST00000282141.3	-	3	459	c.422G>A	c.(421-423)gGg>gAg	p.G141E		NM_020989.3	NP_066269.1	P07315	CRGC_HUMAN	crystallin, gamma C	141	Beta/gamma crystallin 'Greek key' 4.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens			NS(1)|endometrium(1)|large_intestine(2)|lung(5)	9				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		GTATTGCCGCCCCCGGTAGTT	0.632000													37	87					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27190614	27190614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27190614G>A	ENST00000380036.4	+	10	1857	c.1415G>A	c.(1414-1416)gGg>gAg	p.G472E	TEK_ENST00000519097.1_Missense_Mutation_p.G325E|TEK_ENST00000406359.4_Missense_Mutation_p.G429E	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	472	Fibronectin type-III 1.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CCTTACTTTGGGGATGGACCA	0.423000													43	133					0	0	1	0	0
APOBR	55911	broad.mit.edu	37	16	28508889	28508889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28508889G>A	ENST00000564831.1	+	2	2560	c.2527G>A	c.(2527-2529)Gcc>Acc	p.A843T	APOBR_ENST00000431282.1_Missense_Mutation_p.A834T|APOBR_ENST00000328423.5_Missense_Mutation_p.A834T	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	834	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						GCGGGTAGAGGCCGAGGAATC	0.662000													4	10					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49848734	49848734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49848734C>T	ENST00000333486.3	-	9	1252	c.1094G>A	c.(1093-1095)gGt>gAt	p.G365D		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	365	2 approximate repeats.			GVLSPMVAMLGAVAAQEVLKAISR -> RCLEPMVACWVSS CPGSAEGNLQ (in Ref. 1; AAA75388 and 2; AAG49557).	ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AGCTACTGCACCCAGCATGGC	0.597000													22	59					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322559	55322559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55322559C>T	ENST00000314644.2	+	1	777	c.777C>T	c.(775-777)atC>atT	p.I259I		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GTGGGTTTATCTGCATCATAA	0.468000										HNSCC(20;0.049)			35	60					0	0	1	0	0
GTPBP1	9567	broad.mit.edu	37	22	39125543	39125543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39125543C>T	ENST00000216044.5	+	11	2026	c.1793C>T	c.(1792-1794)cCc>cTc	p.P598L		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	598					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					AAAAAGGGCCCCCTGACGAAA	0.607000													7	22					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952815	54952815	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54952815G>A	ENST00000273286.5	-	3	871	c.709C>T	c.(709-711)Cct>Tct	p.P237S	CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.P161S|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	237						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		ACTGGATCAGGAGCAGGAAGA	0.597000													11	21					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148669	34148669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34148669C>T	ENST00000346193.3	-	1	1778	c.1727G>A	c.(1726-1728)cGa>cAa	p.R576Q		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	576								p.R576Q(2)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GTAGGATGCTCGAATCTTGGG	0.512000													15	30					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29917838	29917838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29917838G>A	ENST00000389048.3	-	3	1736	c.830C>T	c.(829-831)tCc>tTc	p.S277F	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	277	MAM 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CAGTGGAGGGGAATACTCCAG	0.567000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				30	79					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886707	3886707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3886707G>A	ENST00000319331.3	+	2	1143	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	128						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		GCATTTGGAGGAAAATCAGAT	0.418000													26	67					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41276491	41276491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41276491G>A	ENST00000361937.3	-	33	4405	c.3981C>T	c.(3979-3981)atC>atT	p.I1327I	INO80_ENST00000401393.3_Silent_p.I1327I			Q9ULG1	INO80_HUMAN	INO80 complex subunit	1327	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GAACAAATGGGATCACCAGGT	0.478000													17	51					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19295170	19295170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:19295170C>T	ENST00000328405.2	+	2	367	c.101C>T	c.(100-102)gCc>gTc	p.A34V		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	34	PAS.					integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CTTGCCAATGCCCAGGTGGCT	0.428000													69	157					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32020752	32020752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32020752G>A	ENST00000375244.3	-	26	9011	c.8810C>T	c.(8809-8811)cCc>cTc	p.P2937L	TNXB_ENST00000375247.2_Missense_Mutation_p.P2935L			P22105	TENX_HUMAN	tenascin XB	2982	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TGTGGGGGCGGGAGTTTCTTC	0.642000													18	52					0	0	1	0	0
IGHV4-28	28400	broad.mit.edu	37	14	106780570	106780570	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106780570G>A	ENST00000390612.2	-	0	365																											GCTTCAGGGAGAACTGGTTCT	0.537000													91	280					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144943768	144943768	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144943768G>A	ENST00000525985.1	-	2	3725	c.3654C>T	c.(3652-3654)acC>acT	p.T1218T				P58107	EPIPL_HUMAN	epiplakin 1	1218						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGCCTCAAGGGTCTCCTGGG	0.716000													7	5					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069366	9069366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9069366G>A	ENST00000397910.4	-	3	18283	c.18080C>T	c.(18079-18081)tCc>tTc	p.S6027F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6029	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGACAGAGGAATGTAGTTT	0.453000													81	154					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126138986	126138986	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126138986G>A	ENST00000393425.1	+	11	1098	c.999G>A	c.(997-999)acG>acA	p.T333T	CCDC37_ENST00000352312.1_Silent_p.T332T|CCDC37_ENST00000505024.1_Silent_p.T333T			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	332								p.T332T(1)		NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		TTCTGCAGACGATGCGGCTGG	0.647000													8	28					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182358140	182358140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182358140C>T	ENST00000397033.2	+	11	1672	c.1242C>T	c.(1240-1242)ttC>ttT	p.F414F		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	414					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CGTCAACCTTCTCACAGGTAA	0.368000													33	83					0	0	1	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6325221	6325221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6325221G>A	ENST00000335585.5	-	9	1175	c.1152C>T	c.(1150-1152)ccC>ccT	p.P384P	PPP2R2C_ENST00000382599.4_Silent_p.P384P|PPP2R2C_ENST00000515571.1_Silent_p.P367P|PPP2R2C_ENST00000506140.1_Silent_p.P377P|PPP2R2C_ENST00000507294.1_Silent_p.P377P	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	384					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						GCACAGCCCGGGGCTTGCTGC	0.617000													9	44					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28619626	28619626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28619626C>T	ENST00000395609.1	-	6	1116	c.358G>A	c.(358-360)Gat>Aat	p.D120N	SULT1A1_ENST00000350842.4_Intron|SULT1A1_ENST00000395607.1_Missense_Mutation_p.D120N|SULT1A1_ENST00000569554.1_Missense_Mutation_p.D120N|SULT1A1_ENST00000314752.7_Missense_Mutation_p.D120N			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	120					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						ACCTTCTGATCCAACAGAGTC	0.577000													28	110					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15061169	15061169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15061169C>T	ENST00000430939.2	-	9	1470	c.1341G>A	c.(1339-1341)ggG>ggA	p.G447G	SLC1A6_ENST00000221742.3_Silent_p.G511G|SLC1A6_ENST00000600144.1_Silent_p.G433G			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	511					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	CAATTGAGTCCCCCAGTACGT	0.562000													22	50					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7762923	7762923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7762923G>A	ENST00000358415.4	+	7	901	c.735G>A	c.(733-735)caG>caA	p.Q245Q	ITIH2_ENST00000379587.4_Silent_p.Q234Q	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	245					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.Q245Q(1)		NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AAGGACAACAGAAGGTACCCT	0.502000													29	95					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754413	76754413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76754413G>A	ENST00000536229.3	+	1	2732	c.2023G>A	c.(2023-2025)Gac>Aac	p.D675N	SALL3_ENST00000575389.2_Missense_Mutation_p.D808N|SALL3_ENST00000537592.2_Missense_Mutation_p.D808N			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	808					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CATGGAGGACGACGCTGAGCT	0.652000													12	34					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61834329	61834329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61834329C>T	ENST00000280772.1	-	37	6501	c.6310G>A	c.(6310-6312)Gga>Aga	p.G2104R	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2104					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTATCTGTTCCAAAAAAGGAA	0.408000													31	88					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141536282	141536282	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141536282C>T	ENST00000350549.3	-	5	992	c.621G>A	c.(619-621)gtG>gtA	p.V207V	PRSS37_ENST00000438520.1_Silent_p.V207V	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	207	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						TGAAGTGCCCCACCTCGATTC	0.502000													30	83					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64973550	64973550	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:64973550G>A	ENST00000399262.2	-	8	2595	c.2377C>T	c.(2377-2379)Cct>Tct	p.P793S	JMJD1C_ENST00000402544.1_Missense_Mutation_p.P574S|JMJD1C_ENST00000542921.1_Missense_Mutation_p.P611S|JMJD1C_ENST00000399251.1_Missense_Mutation_p.P574S	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	793					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGTAAATGAGGGTGATGAACA	0.507000													15	30					0	0	1	0	0
SCGB1C1	147199	broad.mit.edu	37	11	193729	193729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:193729G>A	ENST00000342878.2	+	2	93	c.73G>A	c.(73-75)Gac>Aac	p.D25N	BET1L_ENST00000410108.1_Intron	NM_145651.2	NP_663626.2	Q8TD33	SG1C1_HUMAN	secretoglobin, family 1C, member 1	25						extracellular region	binding			endometrium(1)|liver(2)|lung(1)|skin(1)	5		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CACAGGGGAGGACAACGATGA	0.572000													12	44					0	0	1	0	0
C5orf54	63920	broad.mit.edu	37	5	159821494	159821494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:159821494G>A	ENST00000408953.3	-	2	1511	c.1004C>T	c.(1003-1005)tCc>tTc	p.S335F	C5orf54_ENST00000523213.1_Missense_Mutation_p.S335F	NM_022090.3	NP_071373.2	Q8IZ13	CE054_HUMAN	chromosome 5 open reading frame 54	335										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	12						ttggcctcgggaaagccacct	0.363000													22	37					0	0	1	0	0
LINC00521	256369	broad.mit.edu	37	14	94467737	94467737	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94467737C>T	ENST00000444118.1	+	0	815					NR_024182.1																						GGCCCCCTTTCCTGCATAGCC	0.652000													5	4					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51330994	51330994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51330994C>T	ENST00000326856.4	-	3	247	c.118G>A	c.(118-120)Gag>Aag	p.E40K	KLK15_ENST00000416184.1_Missense_Mutation_p.E41K|KLK15_ENST00000596931.1_Missense_Mutation_p.E40K|KLK15_ENST00000598239.1_Missense_Mutation_p.E41K|KLK15_ENST00000301421.2_Missense_Mutation_p.E41K	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	41	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CGTCCACGCTCGTAGAGAGCC	0.607000													17	31					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36954816	36954816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36954816C>T	ENST00000262865.4	+	10	1244	c.1155C>T	c.(1153-1155)tcC>tcT	p.S385S	CTD-2308N23.2_ENST00000437016.1_RNA|BPI_ENST00000489102.1_3'UTR	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	385					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				CCCTGGCTTCCCTCTTCCTGA	0.597000													11	29					0	0	1	0	0
RNASE1	6035	broad.mit.edu	37	14	21269835	21269835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21269835C>T	ENST00000397967.4	-	2	899	c.393G>A	c.(391-393)gaG>gaA	p.E131E	RNASE1_ENST00000397970.4_Silent_p.E131E|RNASE1_ENST00000412779.2_Silent_p.E131E|RNASE1_ENST00000555698.1_Silent_p.E91E|RNASE1_ENST00000340900.3_Silent_p.E131E	NM_002933.4	NP_002924.1	P07998	RNAS1_HUMAN	ribonuclease, RNase A family, 1 (pancreatic)	131						extracellular region	nucleic acid binding|pancreatic ribonuclease activity|protein binding			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	5	all_cancers(95;0.00671)	all_lung(585;0.235)	Epithelial(56;9.21e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0126)		TGATGTGTCTCTCCTTCGGGC	0.557000													49	99					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129901135	129901135	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129901135G>A	ENST00000368654.3	-	13	9344	c.8969C>T	c.(8968-8970)tCc>tTc	p.S2990F	MKI67_ENST00000368653.3_Missense_Mutation_p.S2630F	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2990					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGGGGGCAGGGAAGTGTTGCT	0.537000													40	85					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287192	202287192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202287192C>T	ENST00000367278.3	+	18	1850	c.1761C>T	c.(1759-1761)ttC>ttT	p.F587F	LGR6_ENST00000439764.2_Silent_p.F448F|LGR6_ENST00000255432.7_Silent_p.F535F	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	587						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						TGACCGTGTTCGCTGGCGGGC	0.617000													10	112					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81304583	81304583	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81304583G>A	ENST00000555265.1	-	11	1264	c.889C>T	c.(889-891)Caa>Taa	p.Q297*	CEP128_ENST00000281129.3_Nonsense_Mutation_p.Q297*|CEP128_ENST00000216517.6_Nonsense_Mutation_p.Q297*			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	297						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						CCTTCTGATTGATTCAATAAC	0.333000													12	100					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115456614	115456614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115456614G>A	ENST00000369522.3	+	20	1906	c.1666G>A	c.(1666-1668)Gaa>Aaa	p.E556K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E556K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	556					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGCAAGAAGAAAGGATGTT	0.244000													19	48					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66082657	66082657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66082657G>A	ENST00000311330.3	-	1	1858	c.1842C>T	c.(1840-1842)ccC>ccT	p.P614P	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	614	Pro-rich.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	GGAGGGCTGCGGGCTGGGTGG	0.622000													45	67					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5013298	5013298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5013298G>A	ENST00000380390.1	+	6	916	c.700G>A	c.(700-702)Gac>Aac	p.D234N	MMP26_ENST00000300762.1_Missense_Mutation_p.D234N			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	234					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CTGGTATCACGACCCTAGAAC	0.488000													19	51					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500456	90500456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90500456G>A	ENST00000325643.5	+	4	1120	c.1054G>A	c.(1054-1056)Ggt>Agt	p.G352S		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CATGGAGGTAGGTGGCTGCAC	0.562000													23	39					0	0	1	0	0
PIF1	80119	broad.mit.edu	37	15	65108835	65108835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65108835G>A	ENST00000268043.4	-	12	1898	c.1804C>T	c.(1804-1806)Cgc>Tgc	p.R602C	PIF1_ENST00000333425.6_Missense_Mutation_p.R602C|PIF1_ENST00000559239.1_Missense_Mutation_p.R602C			Q9H611	PIF1_HUMAN	PIF1 5'-to-3' DNA helicase	602	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						GGGTCACAGCGAACCGCCATG	0.657000													36	174					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198585	20198585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20198585G>A	ENST00000400331.5	-	5	1707	c.1399C>T	c.(1399-1401)Cat>Tat	p.H467Y	MACC1_ENST00000332878.4_Missense_Mutation_p.H467Y|MACC1_ENST00000589011.1_Missense_Mutation_p.H467Y	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	467					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						AATTGTTGATGAACTACTTCA	0.358000													21	58					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5724456	5724456	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5724456C>T	ENST00000546188.1	-	18	1898	c.1827G>A	c.(1825-1827)ccG>ccA	p.P609P	ANO2_ENST00000356134.5_Silent_p.P609P|ANO2_ENST00000327087.8_Silent_p.P608P			Q9NQ90	ANO2_HUMAN	anoctamin 2	613						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GTTCTGTTTTCGGAACCTCTG	0.458000													8	26					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40933038	40933038	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40933038G>A	ENST00000246914.5	+	1	343	c.322G>A	c.(322-324)Ggc>Agc	p.G108S		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	108					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		ACCCCCCGAGGGCACGTGGAC	0.731000													3	11					0	0	1	0	0
GTPBP10	85865	broad.mit.edu	37	7	89983814	89983814	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:89983814C>T	ENST00000222511.6	+	3	336	c.270C>T	c.(268-270)atC>atT	p.I90I	GTPBP10_ENST00000257659.8_Intron	NM_033107.3	NP_149098.2	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 (putative)	90					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(4)	10						ACTGTGAAATCCCTGTGCCTG	0.333000													37	92					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239910	5239910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:5239910G>A	ENST00000274181.7	+	16	2533	c.2395G>A	c.(2395-2397)Ggg>Agg	p.G799R		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	799	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CTACCTGAATGGGCACTGGAC	0.522000													33	107					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89347331	89347331	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89347331G>A	ENST00000301030.4	-	9	6079	c.5619C>T	c.(5617-5619)gtC>gtT	p.V1873V	ANKRD11_ENST00000378330.2_Silent_p.V1873V	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1873	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGGTGACAGTGACAACGGCAG	0.612000													21	60					0	0	1	0	0
PANX3	116337	broad.mit.edu	37	11	124489501	124489501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124489501G>A	ENST00000284288.2	+	4	916	c.849G>A	c.(847-849)ttG>ttA	p.L283L		NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3	283					protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		ACACCATATTGGTTCCAGTGA	0.453000													23	66					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33165256	33165256	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:33165256C>T	ENST00000280979.4	+	9	3110	c.2940C>T	c.(2938-2940)tcC>tcT	p.S980S	AKAP6_ENST00000557272.1_Silent_p.S980S|AKAP6_ENST00000557354.1_Silent_p.S980S	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	980					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ACATGGAGTCCCTTGTGATGG	0.468000													24	53					0	0	1	0	0
TFAP2A	7020	broad.mit.edu	37	6	10410431	10410431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:10410431G>A	ENST00000379613.3	-	2	445	c.189C>T	c.(187-189)ccC>ccT	p.P63P	TFAP2A_ENST00000482890.1_Silent_p.P61P|RP1-290I10.6_ENST00000420777.1_RNA|TFAP2A_ENST00000379608.3_Silent_p.P55P|TFAP2A_ENST00000497266.1_Intron|TFAP2A_ENST00000379604.2_Silent_p.P61P|TFAP2A_ENST00000319516.4_Silent_p.P57P			P05549	AP2A_HUMAN	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	61	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	13	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				TAGGCTGGTAGGGTGGGGGGA	0.657000													15	39					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325516	150325516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150325516C>T	ENST00000328902.5	-	3	386	c.170G>A	c.(169-171)gGa>gAa	p.G57E	GIMAP6_ENST00000493969.1_Intron	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	57							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GATGCTGTTTCCTGTTGCACT	0.542000													132	356					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82937540	82937540	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82937540G>A	ENST00000274341.4	-	5	1690	c.840C>T	c.(838-840)ctC>ctT	p.L280L		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	280	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CACCATCATTGAGACAAGCTT	0.512000													74	194					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23526958	23526958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:23526958G>A	ENST00000296682.3	+	11	1943	c.1761G>A	c.(1759-1761)cgG>cgA	p.R587R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	587					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGTGTGGGCGGGGCTTTAGCT	0.607000										HNSCC(3;0.000094)			25	87					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168114084	168114084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168114084C>T	ENST00000519560.1	-	30	3633	c.3214G>A	c.(3214-3216)Gag>Aag	p.E1072K	SLIT3_ENST00000332966.8_Missense_Mutation_p.E1079K|SLIT3_ENST00000404867.3_Missense_Mutation_p.E1072K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1072	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGTCTGTCTCACAGAGCTTC	0.597000													20	33					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149486857	149486857	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149486857C>T	ENST00000378016.2	+	0	4631							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTGCCTGGCCCCTCCCCAGGC	0.672000													19	38					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64873562	64873562	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64873562G>A	ENST00000533854.1	+	2	349	c.112G>A	c.(112-114)Gag>Aag	p.E38K	CACNG5_ENST00000169565.3_Missense_Mutation_p.E38K|CACNG5_ENST00000307139.3_Missense_Mutation_p.E38K			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	38					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GTACCTGGAGGAGGGTGTGAT	0.622000													22	73					0	0	1	0	0
ZNF625	90589	broad.mit.edu	37	19	12256752	12256752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12256752C>T	ENST00000355738.1	-	4	630	c.281G>A	c.(280-282)gGg>gAg	p.G94E	ZNF625-ZNF20_ENST00000430024.1_Intron|ZNF625_ENST00000439556.2_Missense_Mutation_p.G160E|ZNF625_ENST00000542938.1_Missense_Mutation_p.G94E|ZNF625_ENST00000455799.1_3'UTR			Q96I27	ZN625_HUMAN	zinc finger protein 625	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(4)|skin(2)	14						ATAAGGTTTCCCCCCAGTGTG	0.423000													19	146					0	0	1	0	0
DDX39B	7919	broad.mit.edu	37	6	31503091	31503091	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31503091G>A	ENST00000453105.2	-	5	833	c.647C>T	c.(646-648)cCc>cTc	p.P216L	DDX39B_ENST00000417556.2_Intron|DDX39B_ENST00000458640.1_Intron|DDX39B_ENST00000396172.1_Intron|DDX39B_ENST00000376177.2_Intron|DDX39B_ENST00000415382.2_Intron|ATP6V1G2-DDX39B_ENST00000376185.1_Intron			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0	Helicase ATP-binding.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						ggcgaggaaggggaggaggca	0.542000													18	39					0	0	1	0	0
C11orf16	56673	broad.mit.edu	37	11	8947545	8947545	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8947545C>T	ENST00000326053.5	-	5	775	c.669G>A	c.(667-669)gaG>gaA	p.E223E	C11orf16_ENST00000525780.1_Silent_p.E223E	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	223										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		TGTGCAGCCTCTCCACAGCCT	0.557000													32	100					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155200514	155200514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155200514C>T	ENST00000460012.1	-	23	3568	c.3211G>A	c.(3211-3213)Gaa>Aaa	p.E1071K	PLCH1_ENST00000414191.1_Missense_Mutation_p.E1071K|PLCH1_ENST00000340059.7_Missense_Mutation_p.E1109K|PLCH1_ENST00000334686.6_Missense_Mutation_p.E1071K|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000494598.1_Intron			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1109					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTACCCTTTTCCTTGATTTTC	0.468000													53	100					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134920412	134920412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134920412C>T	ENST00000398015.3	+	12	2597	c.2227C>T	c.(2227-2229)Cgg>Tgg	p.R743W	EPHB1_ENST00000493838.1_Missense_Mutation_p.R304W	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	743	Protein kinase.		R -> Q (in a gastric adenocarcinoma sample; somatic mutation).			integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.R743W(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TTATGTGCATCGGGACCTGGC	0.547000													40	182					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913431	6913431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6913431G>A	ENST00000299459.2	-	1	399	c.301C>T	c.(301-303)Ctt>Ttt	p.L101F		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAAAAGAGAAGTCGAGCTGCG	0.478000													21	64					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91739130	91739130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91739130C>T	ENST00000389857.6	-	30	6012	c.5926G>A	c.(5926-5928)Ggg>Agg	p.G1976R	CCDC88C_ENST00000331194.7_Missense_Mutation_p.G500R	NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1976					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				GCCGGAAGCCCCTCACTGCAG	0.711000													5	25					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76372213	76372213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76372213C>T	ENST00000407242.2	-	3	666	c.424G>A	c.(424-426)Gag>Aag	p.E142K	AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000404995.1_Missense_Mutation_p.E142K|LRRC32_ENST00000464145.1_Intron|LRRC32_ENST00000260061.5_Missense_Mutation_p.E142K	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	142						integral to plasma membrane		p.E142*(1)		endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						AGCAGCCGCTCCAGCAGGCCG	0.687000													15	41					0	0	1	0	0
RNASE12	493901	broad.mit.edu	37	14	21058675	21058675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21058675G>A	ENST00000556526.1	-	1	307	c.208C>T	c.(208-210)Cat>Tat	p.H70Y	RNASE11_ENST00000335950.4_5'UTR|RP11-14J7.6_ENST00000556487.1_RNA|AL163195.3_ENST00000555283.1_RNA|RP11-14J7.6_ENST00000554993.1_RNA|RP11-14J7.6_ENST00000554529.1_RNA|RP11-14J7.6_ENST00000553604.1_RNA	NM_001024822.2	NP_001019993.1	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	70						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			kidney(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		GGCCTCTCATGGATGAAGACA	0.438000													11	123					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82421702	82421702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:82421702C>T	ENST00000370728.1	+	13	2608	c.1963C>T	c.(1963-1965)Ctt>Ttt	p.L655F	LPHN2_ENST00000370723.1_Missense_Mutation_p.L642F|LPHN2_ENST00000335786.5_Missense_Mutation_p.L655F|LPHN2_ENST00000370715.1_Missense_Mutation_p.L642F|LPHN2_ENST00000370725.1_Missense_Mutation_p.L655F|LPHN2_ENST00000359929.3_Missense_Mutation_p.L642F|LPHN2_ENST00000394879.1_Missense_Mutation_p.L642F|LPHN2_ENST00000370727.1_Missense_Mutation_p.L655F|LPHN2_ENST00000370730.1_Missense_Mutation_p.L655F|LPHN2_ENST00000370717.2_Missense_Mutation_p.L655F|LPHN2_ENST00000319517.6_Missense_Mutation_p.L642F|LPHN2_ENST00000370713.1_Missense_Mutation_p.L642F|LPHN2_ENST00000370721.1_Missense_Mutation_p.L580F|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000271029.4_Missense_Mutation_p.L655F			O95490	LPHN2_HUMAN	latrophilin 2	655					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AGCTGACAATCTTTTAGAACC	0.348000													12	68					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168678436	168678436	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168678436C>T	ENST00000519560.1	-	2	644	c.225G>A	c.(223-225)agG>agA	p.R75R	SLIT3_ENST00000332966.8_Silent_p.R75R|SLIT3_ENST00000521130.1_5'UTR|SLIT3_ENST00000404867.3_Silent_p.R75R	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	75					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTTGGTGATCCTGGTGATAT	0.433000													40	77					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36596150	36596150	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:36596150C>T	ENST00000299440.5	+	2	1408	c.1296C>T	c.(1294-1296)tcC>tcT	p.S432S		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	432					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				ATGTGAAGTCCGTGTGCATGA	0.567000									Familial Hemophagocytic Lymphohistiocytosis				20	45					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52886564	52886564	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52886564C>T	ENST00000330722.6	-	1	477	c.409G>A	c.(409-411)Gag>Aag	p.E137K		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	137	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACGGTGACCTCTTGGATGCCT	0.632000													22	58					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169432679	169432679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169432679G>A	ENST00000261509.6	+	2	235	c.24G>A	c.(22-24)gaG>gaA	p.E8E	PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Silent_p.E8E	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	8					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCTCCCATGAGTCCTTCTATG	0.478000									Pancreatic Cancer, Familial Clustering of				26	71					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182359477	182359477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182359477C>T	ENST00000397033.2	+	12	1707	c.1277C>T	c.(1276-1278)tCg>tTg	p.S426L		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	426					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATCAGCAAATCGTTAAGTATG	0.308000													41	93					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21102957	21102957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21102957C>T	ENST00000377122.4	-	23	2653	c.2257G>A	c.(2257-2259)Gac>Aac	p.D753N	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	753					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TGTTTATGGTCCTGGGTATAT	0.328000													15	64					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72071175	72071175	+	Silent	SNP	G	G	A	rs112803189		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72071175G>A	ENST00000265381.4	-	8	1998	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	592	PID.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle		p.F592F(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						CCTCAGACTCGAAGACGTGGC	0.522000													44	157					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374539	31374539	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31374539G>A	ENST00000268296.4	+	14	1675	c.1554G>A	c.(1552-1554)tgG>tgA	p.W518*	ITGAX_ENST00000562522.1_Nonsense_Mutation_p.W518*	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	518					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GCCACCCCTGGGGTCGCTTTG	0.637000													56	101					0	0	1	0	0
PAMR1	25891	broad.mit.edu	37	11	35463233	35463233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:35463233C>T	ENST00000378880.2	-	7	1274	c.829G>A	c.(829-831)Gaa>Aaa	p.E277K	PAMR1_ENST00000378878.3_Missense_Mutation_p.E166K|PAMR1_ENST00000278360.3_Missense_Mutation_p.E294K|PAMR1_ENST00000532848.1_Missense_Mutation_p.E237K	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	277					proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						CAGTTTCTTTCTTCAAGGACT	0.398000													23	40					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35654817	35654817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35654817G>A	ENST00000440995.2	+	7	967	c.967G>A	c.(967-969)Gaa>Aaa	p.E323K	SPEF2_ENST00000356031.3_Missense_Mutation_p.E323K|SPEF2_ENST00000282469.6_Missense_Mutation_p.E323K|SPEF2_ENST00000509059.1_Missense_Mutation_p.E323K			Q9C093	SPEF2_HUMAN	sperm flagellar 2	323					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AATAGCCCACGAAGCACAAGA	0.363000													22	103					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119736782	119736782	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119736782G>A	ENST00000379735.5	-	5	768	c.497C>T	c.(496-498)cCt>cTt	p.P166L	SEC24D_ENST00000280551.6_Missense_Mutation_p.P166L|SEC24D_ENST00000419654.2_5'UTR	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	166	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						TTGAGATCCAGGCTGCAAAAT	0.582000													18	50					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164761751	164761751	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:164761751C>T	ENST00000420696.2	+	3	474	c.286C>T	c.(286-288)Cag>Tag	p.Q96*	PBX1_ENST00000540236.1_Nonsense_Mutation_p.Q96*|PBX1_ENST00000560641.1_5'UTR|PBX1_ENST00000401534.1_Nonsense_Mutation_p.Q96*|PBX1_ENST00000540246.1_5'UTR|PBX1_ENST00000559240.1_Nonsense_Mutation_p.Q96*|PBX1_ENST00000367897.1_Nonsense_Mutation_p.Q96*	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	96					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						CCGAGGAGCCCAGGAGGAGGA	0.532000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								14	35					0	0	1	0	0
GGTLC1	92086	broad.mit.edu	37	20	23965900	23965900	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23965900C>T	ENST00000335694.4	-	6	835	c.631G>A	c.(631-633)Gca>Aca	p.A211T	GGTLC1_ENST00000278765.4_Missense_Mutation_p.A211T|GGTLC1_ENST00000286890.4_Missense_Mutation_p.A211T	NM_178311.2	NP_842563.1	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	211							gamma-glutamyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15						GAGGCAGCTGCCCAGCCACCA	0.592000													27	76					0	0	1	0	0
CCDC24	149473	broad.mit.edu	37	1	44457929	44457929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44457929G>A	ENST00000372318.3	+	3	343	c.172G>A	c.(172-174)Gcc>Acc	p.A58T	SLC6A9_ENST00000372306.3_Intron|CCDC24_ENST00000486064.1_3'UTR|SLC6A9_ENST00000372307.3_Intron	NM_152499.1	NP_689712.1	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	58										endometrium(3)|large_intestine(2)|lung(3)|stomach(1)	9	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				ATCCTCTCAAGCCCCCAGCTC	0.632000													38	158					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659121	196659121	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196659121G>A	ENST00000312428.6	-	57	10757	c.10657C>T	c.(10657-10659)Cga>Tga	p.R3553*	DNAH7_ENST00000409063.1_Nonsense_Mutation_p.R36*	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3553	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGGTATGATCGAATGATATTA	0.453000													50	103					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16035627	16035627	+	Silent	SNP	G	G	A	rs149071621	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16035627G>A	ENST00000326742.7	-	5	592	c.591C>T	c.(589-591)ctC>ctT	p.L197L	CYP4F11_ENST00000402119.3_Silent_p.L197L|CYP4F11_ENST00000248041.7_Silent_p.L197L			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	197					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						CCAAGGTCATGAGGCTGATGT	0.527000													41	75					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049518	9049518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9049518C>T	ENST00000397910.4	-	5	32316	c.32113G>A	c.(32113-32115)Gaa>Aaa	p.E10705K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10707	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCATCTGATTCATGATGAGAA	0.473000													16	255					0	0	1	0	0
ZGLP1	100125288	broad.mit.edu	37	19	10419190	10419190	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10419190G>A	ENST00000403903.3	-	1	1366	c.168C>T	c.(166-168)gcC>gcT	p.A56A	FDX1L_ENST00000541276.1_3'UTR|CTD-2369P2.10_ENST00000452032.2_3'UTR|ZGLP1_ENST00000403352.1_5'UTR	NM_001103167.1	NP_001096637.1	P0C6A0	ZGLP1_HUMAN	zinc finger, GATA-like protein 1	56					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(2)|ovary(1)	6						GGAAGCACAGGGCGGTGACCG	0.667000													6	11					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133900636	133900636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133900636C>T	ENST00000220616.4	+	10	2624	c.2584C>T	c.(2584-2586)Ctc>Ttc	p.L862F	TG_ENST00000377869.1_Missense_Mutation_p.L862F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	862	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGAGAATATCCTCCTGGAGCC	0.537000													13	46					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11070974	11070974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11070974G>A	ENST00000287766.4	+	12	1680	c.1259G>A	c.(1258-1260)aGa>aAa	p.R420K	SLC6A1_ENST00000536032.1_Missense_Mutation_p.R242K	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	420					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CGCAACCGCAGAGAGCTCTTC	0.567000													9	28					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233274432	233274432	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233274432C>T	ENST00000295453.3	+	11	1501	c.1449C>T	c.(1447-1449)ttC>ttT	p.F483F		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	483					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	TCATGGCCTTCGCCGCCTGCC	0.751000													14	25					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120889255	120889255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120889255C>T	ENST00000263713.5	+	18	1777	c.1563C>T	c.(1561-1563)tcC>tcT	p.S521S	EPB41L5_ENST00000443902.2_Silent_p.S521S|EPB41L5_ENST00000452780.1_Silent_p.S521S	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	521						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						CTTTGCTGTCCCCTCGATCCA	0.413000													20	71					0	0	1	0	0
GZMA	3001	broad.mit.edu	37	5	54403622	54403622	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54403622G>A	ENST00000274306.6	+	3	251	c.215_splice	c.e3-1	p.L72_splice		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	72	Peptidase S1.			NL -> IP (in Ref. 5; no nucleotide entry).	cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CTGTTCTCAGGAACAAAAGGT	0.388000													21	69					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111564691	111564691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111564691C>T	ENST00000393934.3	+	4	1460	c.890C>T	c.(889-891)cCt>cTt	p.P297L	PLCXD2_ENST00000477665.1_3'UTR|PHLDB2_ENST00000393923.3_5'UTR	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	0					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CCAGTTTATCCTTTGAGATTC	0.468000													34	93					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14832636	14832636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14832636C>T	ENST00000261170.3	-	6	921	c.785G>A	c.(784-786)cGa>cAa	p.R262Q	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	262					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity	p.R262L(1)		breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AGCCACTGCTCGGTCACCCTT	0.418000													40	99					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16235856	16235856	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16235856C>T	ENST00000375759.3	+	4	1126	c.922C>T	c.(922-924)Cga>Tga	p.R308*		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	308	Ser-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TTCTCCAGCTCGATCAGTTCA	0.443000													19	232					0	0	1	0	0
YIPF3	25844	broad.mit.edu	37	6	43481164	43481164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43481164G>A	ENST00000372422.2	-	5	649	c.467C>T	c.(466-468)cCt>cTt	p.P156L	YIPF3_ENST00000506469.1_Missense_Mutation_p.P162L	NM_015388.3	NP_056203.2	Q9GZM5	YIPF3_HUMAN	Yip1 domain family, member 3	156					cell differentiation	integral to membrane|plasma membrane|transport vesicle				large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			CAGCATGAGAGGTCCATAGAG	0.478000													19	33					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38937179	38937179	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38937179C>T	ENST00000355481.4	+	8	830	c.699C>T	c.(697-699)tcC>tcT	p.S233S	RYR1_ENST00000359596.3_Silent_p.S233S|RYR1_ENST00000360985.3_Silent_p.S233S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	233	MIR 3.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGACCATTTCCCCTGCTGACA	0.587000													26	75					0	0	1	0	0
DHRS2	10202	broad.mit.edu	37	14	24108096	24108096	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24108096G>C	ENST00000250383.6	+	2	499	c.23G>C	c.(22-24)gGc>gCc	p.G8A	DHRS2_ENST00000553896.1_3'UTR|DHRS2_ENST00000344777.7_Missense_Mutation_p.G8A	NM_005794.3	NP_005785.1	Q13268	DHRS2_HUMAN	dehydrogenase/reductase (SDR family) member 2	0					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00659)		GTTGCCCGGGGCTACCAGGGC	0.557000													38	86					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410142	159410142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159410142C>T	ENST00000423932.3	+	1	631	c.594C>T	c.(592-594)tcC>tcT	p.S198S	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	198					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TGAAGCTCTCCTGCATTGACA	0.438000													68	146					0	0	1	0	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238552	71238552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71238552C>T	ENST00000398536.4	+	1	240	c.206C>T	c.(205-207)tCc>tTc	p.S69F		NM_001012503.1	NP_001012521.1	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	69	7 X 4 AA repeats of C-C-X-P.					keratin filament				breast(1)|endometrium(1)|kidney(3)|lung(6)|ovary(1)	12						GGCTGTGGCTCCTGTGGGGGC	0.652000													57	254					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136570068	136570068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136570068G>A	ENST00000264162.2	-	7	2176	c.2166C>T	c.(2164-2166)tcC>tcT	p.S722S		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	722	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAATCCAAGAGGATGAGGTCT	0.522000													36	70					0	0	1	0	0
FBXO31	79791	broad.mit.edu	37	16	87377322	87377322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:87377322G>A	ENST00000311635.7	-	4	551	c.539C>T	c.(538-540)cCc>cTc	p.P180L		NM_024735.3	NP_079011.3	Q5XUX0	FBX31_HUMAN	F-box protein 31	180					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0272)		ATCGACGTGGGGGTCATGGGG	0.592000													10	62					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114537894	114537894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:114537894G>A	ENST00000371920.3	+	3	260	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K	LUZP4_ENST00000451986.2_Intron	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	85						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						CAACTCTGAGGAAGGAAATCA	0.343000													64	31					0	0	1	0	0
HDGFRP3	50810	broad.mit.edu	37	15	83808025	83808025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83808025G>A	ENST00000299633.4	-	6	1212	c.609C>T	c.(607-609)acC>acT	p.T203T		NM_016073.3	NP_057157.1	Q9Y3E1	HDGR3_HUMAN		203					cell proliferation	nucleus	growth factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						ATGGTAGTTAGGTCTGTAAAA	0.313000													11	104					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38040710	38040710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38040710C>T	ENST00000599616.1	+	6	493	c.493C>T	c.(493-495)Cgt>Tgt	p.R165C	SH3BP1_ENST00000336738.5_Missense_Mutation_p.R229C|SH3BP1_ENST00000495174.1_3'UTR|SH3BP1_ENST00000357436.4_Missense_Mutation_p.R229C|Z83844.1_ENST00000456099.1_RNA|SH3BP1_ENST00000442465.2_Missense_Mutation_p.R229C			Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	229	BAR.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					CTACTTCATTCGTGTGAGTCC	0.582000													49	214					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	6030491	6030491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6030491C>T	ENST00000546188.1	-	3	308	c.237G>A	c.(235-237)ttG>ttA	p.L79L	ANO2_ENST00000356134.5_Silent_p.L79L|ANO2_ENST00000327087.8_Silent_p.L79L			Q9NQ90	ANO2_HUMAN	anoctamin 2	83						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GACGGGCCTCCAAGGACACAG	0.562000													10	44					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	90010762	90010762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:90010762G>A	ENST00000428670.3	-	12	2340	c.1884C>T	c.(1882-1884)gaC>gaT	p.D628D	ATP2B1_ENST00000261173.2_Silent_p.D628D|ATP2B1_ENST00000359142.3_Silent_p.D628D|ATP2B1_ENST00000348959.3_Silent_p.D628D|ATP2B1_ENST00000393164.2_Silent_p.D371D			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	628					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						TATCATCACGGTCCCTTGGTC	0.368000													17	106					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564036	176564036	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176564036C>T	ENST00000367662.3	+	3	2460	c.1296C>T	c.(1294-1296)gcC>gcT	p.A432A	PAPPA2_ENST00000367661.3_Silent_p.A432A	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	432					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGTCGACCGCCCTGCCACAAA	0.562000													29	83					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027865	55027865	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:55027865G>A	ENST00000371336.3	+	5	1834	c.1633G>A	c.(1633-1635)Gaa>Aaa	p.E545K	CASS4_ENST00000360314.3_Missense_Mutation_p.E545K|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	545					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						TTGGCCTCTGGAAGTTCTTGT	0.498000													23	54					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180372697	180372697	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:180372697C>T	ENST00000273654.4	-	13	1654	c.1035G>A	c.(1033-1035)ttG>ttA	p.L345L	CCDC39_ENST00000442201.2_Silent_p.L261L			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	261					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTTCTTTAACCAAATTTTCTT	0.284000													7	23					0	0	1	0	0
PMVK	10654	broad.mit.edu	37	1	154898850	154898850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154898850C>T	ENST00000368467.3	-	4	727	c.422G>A	c.(421-423)cGg>cAg	p.R141Q		NM_006556.3	NP_006547.1	Q15126	PMVK_HUMAN	phosphomevalonate kinase	141					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CACCCAGCCCCGCTGCTGTCG	0.632000													17	34					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796745	62796745	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62796745G>A	ENST00000582986.1	-	0	1175					NR_024386.1																						ACCTTCTGCAGGGCCTCCCGC	0.667000													10	43					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30703584	30703584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30703584C>T	ENST00000256246.2	-	1	3024	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	984										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAAGATGCTTCATCACTTAGG	0.348000													37	141					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40814611	40814611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40814611G>A	ENST00000396617.3	-	12	2421	c.1831C>T	c.(1831-1833)Cct>Tct	p.P611S	MKL1_ENST00000407029.1_Missense_Mutation_p.P611S|MKL1_ENST00000355630.3_Missense_Mutation_p.P611S|MKL1_ENST00000402042.1_Missense_Mutation_p.P561S			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	611	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						ACAGCACAAGGGTCTATGTGG	0.701000			T	RBM15	acute megakaryocytic leukemia								8	24					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117509617	117509617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:117509617C>T	ENST00000393203.2	+	6	1871	c.1724C>T	c.(1723-1725)tCc>tTc	p.S575F		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	575	Ig-like C2-type 5.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		AAAGTATCTTCCAAGAATATT	0.478000													12	56					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1258015	1258015	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1258015C>T	ENST00000348261.5	+	16	3405	c.3157C>T	c.(3157-3159)Ctg>Ttg	p.L1053L	CACNA1H_ENST00000565831.1_Silent_p.L1053L|CACNA1H_ENST00000358590.4_Silent_p.L1053L	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1053					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCCCGCAGAGCTGAAGATGTG	0.667000													5	9					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849373	98849373	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:98849373G>A	ENST00000554295.1	-	0	1550					NR_033801.1																						AGAACACGATGAAAGGCGTGG	0.527000													5	11					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59853806	59853806	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59853806G>A	ENST00000259008.2	-	14	2320	c.2053C>T	c.(2053-2055)Cag>Tag	p.Q685*	BRIP1_ENST00000583837.1_5'UTR|BRIP1_ENST00000577598.1_Nonsense_Mutation_p.Q685*	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	685					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						CTCACAGTCTGGCACACAGAT	0.393000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					67	139					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55569084	55569084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55569084C>T	ENST00000395445.1	-	36	5120	c.4726G>A	c.(4726-4728)Gaa>Aaa	p.E1576K	PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395440.1_Missense_Mutation_p.E510K|PCDH15_ENST00000395446.1_Missense_Mutation_p.E772K|PCDH15_ENST00000395442.1_Missense_Mutation_p.E441K|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395438.1_3'UTR	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTATCTTCTTCCTCAAGGCGT	0.418000										HNSCC(58;0.16)			24	43					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9258912	9258912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9258912C>T	ENST00000318602.7	-	10	1331	c.1024G>A	c.(1024-1026)Gaa>Aaa	p.E342K		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	342					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	CTTGTGATTTCACTGGACTGC	0.408000													41	66					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55044969	55044969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55044969C>T	ENST00000335056.3	+	3	127	c.89C>T	c.(88-90)tCc>tTc	p.S30F																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GACAAGTTCTCCCTGTCAGCC	0.552000													7	74					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207173411	207173411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207173411G>A	ENST00000374423.3	+	5	4545	c.4159G>A	c.(4159-4161)Gaa>Aaa	p.E1387K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1387							nucleic acid binding|zinc ion binding	p.E1387K(2)		endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ACCTGTCAAAGAAATAAATCT	0.353000													21	35					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21086851	21086851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21086851C>T	ENST00000261383.3	-	21	3000	c.3001G>A	c.(3001-3003)Gaa>Aaa	p.E1001K	DNAH3_ENST00000415178.1_Missense_Mutation_p.E1001K	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1001	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGAGAGTATTCCTTGCTGGCA	0.463000													18	67					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039343	11039343	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039343C>T	ENST00000470054.1	-	0	860									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTTGATCTTCGCCACAAATA	0.383000													24	410					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95777493	95777493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95777493C>T	ENST00000414645.2	+	9	1052	c.953C>T	c.(952-954)tCt>tTt	p.S318F		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	318						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					TTGTTGGTATCTCCTTTATTA	0.289000													51	145					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134993876	134993876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:134993876C>T	ENST00000535938.1	+	18	2452	c.2285C>T	c.(2284-2286)tCt>tTt	p.S762F	SAGE1_ENST00000537770.1_Missense_Mutation_p.S386F|SAGE1_ENST00000370709.3_Missense_Mutation_p.S762F|SAGE1_ENST00000324447.3_Missense_Mutation_p.S762F	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	762										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					GCATTGGATTCTTTCTCTCAC	0.423000													61	96					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117311310	117311310	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:117311310C>T	ENST00000369478.3	+	5	1069	c.961C>T	c.(961-963)Cac>Tac	p.H321Y		NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	321	Pro-rich.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	CACACAAGTTCACCAGCAGAA	0.582000													62	163					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123984630	123984630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:123984630G>A	ENST00000306315.5	-	4	1882	c.1447C>T	c.(1447-1449)Cca>Tca	p.P483S	ZNF608_ENST00000504926.1_Missense_Mutation_p.P56S	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	483						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCACAATTTGGGGGTGTCCTT	0.562000													29	95					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38877379	38877379	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38877379G>A	ENST00000359357.3	+	63	9202	c.8948G>A	c.(8947-8949)aGg>aAg	p.R2983K	DNAH8_ENST00000441566.1_Missense_Mutation_p.R2947K|DNAH8_ENST00000449981.2_Missense_Mutation_p.R3200K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CGCTGGCCAAGGGAGGCTCTG	0.448000													11	117					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307705	140307705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140307705G>A	ENST00000253807.2	+	1	1228	c.1228G>A	c.(1228-1230)Gaa>Aaa	p.E410K	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.E410K|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGATCAGTGAATACCAAGT	0.527000													8	67					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3889576	3889576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3889576C>T	ENST00000520002.1	-	4	1016	c.461G>A	c.(460-462)gGa>gAa	p.G154E	CSMD1_ENST00000542608.1_Missense_Mutation_p.G154E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G154E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G154E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G154E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G154E|CSMD1_ENST00000539096.1_Missense_Mutation_p.G154E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	154	Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATGCAGAACTCCTTTCAGGAT	0.448000													16	45					0	0	1	0	0
ACTL7A	10881	broad.mit.edu	37	9	111625524	111625524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111625524G>A	ENST00000333999.3	+	1	922	c.922G>A	c.(922-924)Gag>Aag	p.E308K		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	308						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGATGGGAAGGAGATTCAGCT	0.542000													24	58					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634297	180634297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:180634297C>T	ENST00000410066.1	-	3	789	c.186G>A	c.(184-186)gtG>gtA	p.V62V		NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	62						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TCAGCTGCTTCACTCGTTTGC	0.597000													22	43					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110826853	110826853	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110826853C>T	ENST00000375820.4	-	39	3467	c.3346G>A	c.(3346-3348)Gaa>Aaa	p.E1116K		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1116	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TCACCTTTTTCTCCAGGTAGC	0.483000													20	39					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100623449	100623449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:100623449C>T	ENST00000317233.4	-	6	753	c.518G>A	c.(517-519)gGa>gAa	p.G173E	AFF3_ENST00000356421.2_Missense_Mutation_p.G198E|AFF3_ENST00000409236.1_Missense_Mutation_p.G173E|AFF3_ENST00000409579.1_Missense_Mutation_p.G198E	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	173					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						AACACCATCTCCAAGCAAGGT	0.547000													17	45					0	0	1	0	0
CYP2A7	1549	broad.mit.edu	37	19	41386449	41386449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41386449C>T	ENST00000301146.4	-	3	969	c.428G>A	c.(427-429)cGa>cAa	p.R143Q	CYP2A7_ENST00000291764.3_Missense_Mutation_p.R92Q|CTC-490E21.12_ENST00000601627.1_Intron	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	143						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CTCGATGCCTCGCTTGCCCAC	0.672000													11	32					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27167606	27167606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27167606G>A	ENST00000288699.6	+	12	1681	c.1523G>A	c.(1522-1524)gGa>gAa	p.G508E	DPYSL5_ENST00000401478.1_Missense_Mutation_p.G508E	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	508					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAAGAGATGGGAACCCCACTC	0.582000													31	95					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111595608	111595608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:111595608C>T	ENST00000261486.5	-	8	987	c.711G>A	c.(709-711)aaG>aaA	p.K237K		NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	237	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TCCCCACTTGCTTTTTATTCT	0.408000													30	83					0	0	1	0	0
GJB4	127534	broad.mit.edu	37	1	35227159	35227159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35227159G>A	ENST00000339480.1	+	2	674	c.304G>A	c.(304-306)Gag>Aag	p.E102K	RP1-34M23.5_ENST00000542839.1_RNA	NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	102					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CGAGGAACGCGAGCGCAAGCA	0.647000													13	22					0	0	1	0	0
MED14	9282	broad.mit.edu	37	X	40551483	40551483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:40551483G>A	ENST00000324817.1	-	15	2050	c.1932C>T	c.(1930-1932)ttC>ttT	p.F644F		NM_004229.3	NP_004220.2	O60244	MED14_HUMAN	mediator complex subunit 14	644	Interaction with SREBF1.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(2)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ACATAGCGACGAAGTGGGCTA	0.378000													28	13					0	0	1	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7509157	7509157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7509157C>T	ENST00000593531.1	+	7	737	c.737C>T	c.(736-738)cCc>cTc	p.P246L	ARHGEF18_ENST00000319670.9_Silent_p.A130A|ARHGEF18_ENST00000359920.6_Silent_p.A288A																							ACTCCAGGGCCCTGCAGGAGG	0.617000													19	51					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79399020	79399020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79399020G>A	ENST00000264895.6	+	55	8343	c.7903G>A	c.(7903-7905)Gat>Aat	p.D2635N		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2630	Calx-beta 1.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGTCATCAACGATGATGACGT	0.483000													9	17					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123515039	123515039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:123515039C>T	ENST00000422452.2	-	32	7609	c.7546G>A	c.(7546-7548)Gga>Aga	p.G2516R	TENM1_ENST00000371130.3_Missense_Mutation_p.G2509R|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TGCTTCCCTCCTTCAAGGCAC	0.453000													74	50					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359609	66359609	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66359609G>A	ENST00000333861.3	-	1	945	c.878C>T	c.(877-879)cCc>cTc	p.P293L		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	293										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CCTGCTGGTGGGGGCCACAGG	0.602000													35	73					0	0	1	0	0
HFE2	148738	broad.mit.edu	37	1	145416700	145416700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145416700G>A	ENST00000336751.5	+	4	1283	c.1045G>A	c.(1045-1047)Gaa>Aaa	p.E349K	HFE2_ENST00000475797.1_Missense_Mutation_p.E123K|HFE2_ENST00000497365.1_Missense_Mutation_p.E123K|HFE2_ENST00000357836.5_Missense_Mutation_p.E236K	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	349					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCTGTGCAAGGAAGGGCTTCC	0.527000													16	47					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16955966	16955966	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:16955966A>T	ENST00000377833.4	-	48	7442	c.7377T>A	c.(7375-7377)tcT>tcA	p.S2459S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2459	CUB 18.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGTTCCAATAGAGCCCTGAA	0.478000													31	75					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179582436	179582436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179582436G>A	ENST00000589042.1	-	87	25389	c.25165C>T	c.(25165-25167)Ctt>Ttt	p.L8389F	TTN_ENST00000342992.6_Missense_Mutation_p.L7145F|TTN_ENST00000591111.1_Missense_Mutation_p.L8072F|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8072	Ig-like 66.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACACTTGAAGAGGTTCTGAG	0.408000													4	27					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152737379	152737379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152737379C>T	ENST00000360283.6	-	3	480	c.223G>A	c.(223-225)Gag>Aag	p.E75K	CACNB4_ENST00000427385.1_Missense_Mutation_p.E91K|CACNB4_ENST00000534999.1_Missense_Mutation_p.E75K|CACNB4_ENST00000201943.5_Missense_Mutation_p.E109K|CACNB4_ENST00000539935.1_Missense_Mutation_p.E109K|CACNB4_ENST00000397327.2_Missense_Mutation_p.E62K			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	109					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GGCACATCCTCGTCCAGGGCG	0.473000													13	26					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952418	119952418	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119952418G>A	ENST00000307142.4	+	4	2684	c.2488G>A	c.(2488-2490)Gga>Aga	p.G830R	SYNPO2_ENST00000429713.2_Missense_Mutation_p.G830R|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Missense_Mutation_p.G830R	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	830						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TCCCTTCAAAGGACCACAAGC	0.532000													21	51					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81599243	81599243	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:81599243C>T	ENST00000356860.3	-	28	2600	c.2262G>A	c.(2260-2262)agG>agA	p.R754R	CACNA2D1_ENST00000535308.1_Intron|CACNA2D1_ENST00000356253.5_Silent_p.R766R	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	766						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TATCTAGGCTCCTTTTATAGA	0.338000													21	81					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1247914	1247914	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1247914G>A	ENST00000447027.1	+	4	327	c.269G>A	c.(268-270)gGc>gAc	p.G90D	MUC5B_ENST00000529681.1_Missense_Mutation_p.G90D			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	90	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACCTTCGACGGCGACGTCTTC	0.647000													7	25					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97078893	97078893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:97078893C>T	ENST00000524981.3	+	9	1244	c.1244C>T	c.(1243-1245)tCa>tTa	p.S415L				Q6ZTY8	CL063_HUMAN		389										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						TTTGGCCCCTCACTCACCAAT	0.468000													16	40					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005313	74005313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74005313C>T	ENST00000301607.3	-	22	4226	c.3973G>A	c.(3973-3975)Gtg>Atg	p.V1325M	EVPL_ENST00000586740.1_Missense_Mutation_p.V1347M	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1325	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						TTCTCCAGCACCGGGTCCTTC	0.697000													18	264					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121957514	121957514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121957514C>T	ENST00000379692.4	-	4	2138	c.1612G>A	c.(1612-1614)Ggc>Agc	p.G538S		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	538	Fibronectin type-III 2.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						TAAGATTTGCCAGGCTGAAGA	0.403000													49	116					0	0	1	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490495	141490495	+	Missense_Mutation	SNP	C	C	T	rs146440743		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141490495C>T	ENST00000247883.4	+	1	479	c.334C>T	c.(334-336)Cgc>Tgc	p.R112C		NM_018980.2	NP_061853.1	Q9NYW4	TA2R5_HUMAN	taste receptor, type 2, member 5	112					chemosensory behavior|sensory perception of taste		taste receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9	Melanoma(164;0.0171)					GACCTTCGATCGCCCGGCCTA	0.483000													7	87					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757435	8757435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8757435G>A	ENST00000229335.6	-	4	614	c.511C>T	c.(511-513)Cgt>Tgt	p.R171C	AICDA_ENST00000537228.1_Missense_Mutation_p.R161C	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	171					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					CTGGAGAGACGAACTGAATTT	0.368000													36	160					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2595295	2595295	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2595295C>T	ENST00000399655.1	+	6	1048	c.783C>T	c.(781-783)atC>atT	p.I261I	CACNA1C_ENST00000347598.4_Silent_p.I261I|CACNA1C_ENST00000399591.1_Silent_p.I261I|CACNA1C_ENST00000480911.1_Silent_p.I261I|CACNA1C_ENST00000344100.3_Silent_p.I261I|CACNA1C_ENST00000399597.1_Silent_p.I261I|CACNA1C_ENST00000335762.5_Silent_p.I261I|CACNA1C_ENST00000399595.1_Silent_p.I261I|CACNA1C_ENST00000399603.1_Silent_p.I261I|CACNA1C_ENST00000399617.1_Silent_p.I261I|CACNA1C_ENST00000399606.1_Silent_p.I261I|CACNA1C_ENST00000399621.1_Silent_p.I261I|CACNA1C_ENST00000399601.1_Silent_p.I261I|CACNA1C_ENST00000399638.1_Silent_p.I261I|CACNA1C_ENST00000399649.1_Silent_p.I261I|CACNA1C_ENST00000399644.1_Silent_p.I261I|CACNA1C_ENST00000399629.1_Silent_p.I261I|CACNA1C_ENST00000327702.7_Silent_p.I261I|CACNA1C_ENST00000399634.1_Silent_p.I261I|CACNA1C_ENST00000399637.1_Silent_p.I261I|CACNA1C_ENST00000406454.3_Silent_p.I261I|CACNA1C_ENST00000402845.3_Silent_p.I261I|CACNA1C_ENST00000399641.1_Silent_p.I261I	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	261					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGAATTCCATCATCAAGGCCA	0.562000													4	24					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15760766	15760766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15760766C>T	ENST00000221307.7	+	7	739	c.691C>T	c.(691-693)Ctt>Ttt	p.L231F	CYP4F3_ENST00000586182.1_Missense_Mutation_p.L231F|CYP4F3_ENST00000585846.1_Missense_Mutation_p.L231F|CYP4F3_ENST00000591058.1_Missense_Mutation_p.L231F	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	231					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GCTCAGTGCCCTTGTGACAAA	0.527000													76	154					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73063711	73063711	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73063711G>A	ENST00000429829.1	-	0	8877					NR_001564.2																						GTACTACAAAGGAAAGGTGAT	0.403000													12	3					0	0	1	0	0
TRAV10	28676	broad.mit.edu	37	14	22294096	22294096	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22294096C>T	ENST00000390432.2	+	0	236																											GGTCCTGTTTCCCTGACAATC	0.458000													54	100					0	0	1	0	0
SDHAF2	54949	broad.mit.edu	37	11	61213508	61213508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61213508C>T	ENST00000301761.2	+	4	540	c.466C>T	c.(466-468)Cca>Tca	p.P156S	SDHAF2_ENST00000537782.1_3'UTR|SDHAF2_ENST00000542074.1_3'UTR|RP11-286N22.8_ENST00000543044.1_Missense_Mutation_p.P144S|RP11-286N22.8_ENST00000544880.1_Intron|SDHAF2_ENST00000543265.1_3'UTR	NM_017841.2	NP_060311.1	Q9NX18	SDHF2_HUMAN	succinate dehydrogenase complex assembly factor 2	156					mitochondrial electron transport, succinate to ubiquinone|protein-FAD linkage	mitochondrion	protein binding			large_intestine(3)|lung(4)|ovary(2)	9						ACTGCGTGCCCCAGATCTTGA	0.473000											OREG0021000	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	91					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95335847	95335847	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95335847G>A	ENST00000371483.4	+	2	623		c.e2-1		FFAR4_ENST00000371481.4_Splice_Site|FFAR4_ENST00000604414.1_Splice_Site	NM_181745.3	NP_859529.2			free fatty acid receptor 4									p.?(1)									TTTGTAACTAGGAAATTTCGA	0.438000													42	94					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88241775	88241775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88241775G>A	ENST00000418177.2	-	10	3991	c.3624C>T	c.(3622-3624)agC>agT	p.S1208S	GRM5_ENST00000455756.2_Silent_p.S1176S|GRM5_ENST00000305447.4_Silent_p.S1208S|GRM5_ENST00000393297.1_Silent_p.S938S|GRM5_ENST00000305432.5_Silent_p.S1176S|GRM5-AS1_ENST00000526448.1_RNA			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	1208					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ACGACGAGGAGCTCTGAGTGT	0.587000													16	42					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35387967	35387967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35387967C>T	ENST00000311565.4	+	5	543	c.194C>T	c.(193-195)gCc>gTc	p.A65V	PPARD_ENST00000360694.3_Missense_Mutation_p.A65V|PPARD_ENST00000337400.2_Missense_Mutation_p.A65V|PPARD_ENST00000418635.2_Intron|PPARD_ENST00000448077.2_Missense_Mutation_p.A26V|PPARD_ENST00000540939.1_Intron|PPARD_ENST00000444397.1_Missense_Mutation_p.A65V	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	65					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	TGTGACGGGGCCTCATGCGGC	0.637000													19	43					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111540084	111540084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:111540084G>A	ENST00000261486.5	-	15	1640	c.1364C>T	c.(1363-1365)cCt>cTt	p.P455L	CTC-459M5.2_ENST00000506875.1_RNA|EPB41L4A_ENST00000507810.1_5'UTR	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	455						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		CCTCCTCACAGGCTGTACAGA	0.483000													57	131					0	0	1	0	0
ESM1	11082	broad.mit.edu	37	5	54277898	54277898	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54277898C>T	ENST00000381405.4	-	2	523	c.378G>A	c.(376-378)acG>acA	p.T126T	ESM1_ENST00000598310.1_Intron|ESM1_ENST00000381403.4_Intron	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	126					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			GGCATTTTCCCGTCCCCCTGT	0.493000													49	107					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74607058	74607058	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74607058A>G	ENST00000253159.8	+	10	1699	c.1501A>G	c.(1501-1503)Atc>Gtc	p.I501V	ZNF236_ENST00000320610.9_Missense_Mutation_p.I503V	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	501					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GGTCCGCCACATCCGCATCCA	0.647000													44	130					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149497196	149497196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149497196G>A	ENST00000261799.4	-	22	3591	c.3122C>T	c.(3121-3123)tCc>tTc	p.S1041F		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	1041					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TAGGCTGGGGGAACCCTCCAG	0.612000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								18	55					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183714469	183714469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183714469G>A	ENST00000511685.1	+	26	6767	c.6644G>A	c.(6643-6645)cGa>cAa	p.R2215Q	TENM3_ENST00000406950.2_Missense_Mutation_p.R2215Q					teneurin transmembrane protein 3																		CTTCTAACTCGAGTTTACAGT	0.483000													23	51					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137707461	137707461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137707461G>A	ENST00000371817.3	+	51	4468	c.4054G>A	c.(4054-4056)Gag>Aag	p.E1352K		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1352	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCCCCCGGAGAGCCTGGCCC	0.622000													5	23					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152737408	152737408	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152737408G>T	ENST00000360283.6	-	3	451	c.194C>A	c.(193-195)aCa>aAa	p.T65K	CACNB4_ENST00000427385.1_Missense_Mutation_p.T81K|CACNB4_ENST00000534999.1_Missense_Mutation_p.T65K|CACNB4_ENST00000201943.5_Missense_Mutation_p.T99K|CACNB4_ENST00000539935.1_Missense_Mutation_p.T99K|CACNB4_ENST00000397327.2_Missense_Mutation_p.T52K			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	99					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GCTCACATTTGTCTTCACGGC	0.448000													14	31					4.7546e-09	4.7721e-09	1	1	0
CTBP2	1488	broad.mit.edu	37	10	126715662	126715662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:126715662G>A	ENST00000309035.6	-	1	797	c.667C>T	c.(667-669)Cct>Tct	p.P223S	CTBP2_ENST00000494626.2_Intron|CTBP2_ENST00000411419.2_Intron|CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000337195.5_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		TGTCTGGCAGGGGCAGGGTCA	0.677000													27	75					0	0	1	0	0
TAS2R14	50840	broad.mit.edu	37	12	11091012	11091012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11091012G>A	ENST00000537503.1	-	1	850	c.795C>T	c.(793-795)tcC>tcT	p.S265S	TAS2R14_ENST00000381852.4_5'UTR|PRR4_ENST00000536668.1_Intron	NM_023922.1	NP_076411.1	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	265					detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	8						CCATCACCTGGGAAAGAATAA	0.423000													11	124					0	0	1	0	0
CCBL1	883	broad.mit.edu	37	9	131600089	131600089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131600089G>A	ENST00000436267.2	-	8	873	c.724C>T	c.(724-726)Ccc>Tcc	p.P242S	CCBL1_ENST00000302586.3_Missense_Mutation_p.P148S|CCBL1_ENST00000320665.6_Missense_Mutation_p.P98S|CCBL1_ENST00000483599.1_5'UTR			Q16773	KAT1_HUMAN	cysteine conjugate-beta lyase, cytoplasmic	148					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	TTCTGGATGGGACCCTGCAAG	0.582000													5	61					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664043	44664043	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44664043G>A	ENST00000454036.1	+	3	293	c.216_splice	c.e3-1	p.E73_splice	SLC12A5_ENST00000243964.3_Splice_Site_p.E50_splice|SLC12A5_ENST00000539566.1_Splice_Site_p.E50_splice|SLC12A5_ENST00000372315.1_Splice_Site_p.E50_splice	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	73					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCCTCCATAGGAGGAGATGGA	0.592000													29	262					0	0	1	0	0
OR1B1	347169	broad.mit.edu	37	9	125391169	125391169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125391169G>A	ENST00000304833.3	-	1	683	c.646C>T	c.(646-648)Ccc>Tcc	p.P216S	RP11-64P14.7_ENST00000431442.1_RNA|RP11-64P14.7_ENST00000419604.1_RNA	NM_001004450.1	NP_001004450.1	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B, member 1	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)	16						AGGGCACAGGGGCCCAGCATA	0.537000													8	62					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242078	60242078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:60242078C>T	ENST00000269499.5	+	13	3182	c.2764C>T	c.(2764-2766)Ccc>Tcc	p.P922S	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.P601S	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	922					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						ACCAGGCTCTCCCCTTGCTGC	0.617000													24	49					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46474037	46474037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46474037C>T	ENST00000361297.2	+	9	1255	c.972C>T	c.(970-972)ttC>ttT	p.F324F	MAST2_ENST00000372008.1_Silent_p.F209F|MAST2_ENST00000372009.2_Silent_p.F324F	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	324					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					AAGAAAGATTCCCAAAGGTAA	0.428000													11	41					0	0	1	0	0
C9orf47	286223	broad.mit.edu	37	9	91606031	91606031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91606031C>T	ENST00000375851.2	+	1	254	c.121C>T	c.(121-123)Cca>Tca	p.P41S	C9orf47_ENST00000334490.5_Missense_Mutation_p.P41S|C9orf47_ENST00000375850.3_Missense_Mutation_p.P41S	NM_001001938.3|NM_001142413.1	NP_001001938.1|NP_001135885.1	Q6ZRZ4	CI047_HUMAN	chromosome 9 open reading frame 47	41						extracellular region				endometrium(1)|large_intestine(1)|liver(1)|lung(1)	4						GGACCTGGTTCCAAGCCTGTT	0.612000													13	22					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100609643	100609643	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100609643T>G	ENST00000319509.7	+	8	2375	c.2375T>G	c.(2374-2376)gTg>gGg	p.V792G	RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GCGCTGCTGGTGCTGCTGCTG	0.791000													3	2					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150868557	150868557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150868557G>A	ENST00000370353.3	+	3	487	c.97G>A	c.(97-99)Gag>Aag	p.E33K	PRRG3_ENST00000370354.1_Missense_Mutation_p.E41K|PRRG3_ENST00000538575.1_Missense_Mutation_p.E33K			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	33	Gla.					extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					GGGCACCATCGAGCGAGAGTG	0.562000													26	20					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32036794	32036794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32036794C>T	ENST00000375244.3	-	16	5908	c.5707G>A	c.(5707-5709)Gtg>Atg	p.V1903M	TNXB_ENST00000375247.2_Missense_Mutation_p.V1903M			P22105	TENX_HUMAN	tenascin XB	1985	Fibronectin type-III 11.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCCTCAGTCACCATCCAGGAG	0.582000													45	93					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1562025	1562025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:1562025G>A	ENST00000572621.1	-	32	5436	c.5171C>T	c.(5170-5172)cCt>cTt	p.P1724L	PRPF8_ENST00000304992.6_Missense_Mutation_p.P1724L			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1724	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TTGTATGAGAGGCTTGCTGCC	0.498000													25	26					0	0	1	0	0
FAM73B	84895	broad.mit.edu	37	9	131804628	131804628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131804628C>T	ENST00000277475.5	+	3	328	c.142C>T	c.(142-144)Ctc>Ttc	p.L48F	FAM73B_ENST00000406926.2_Missense_Mutation_p.L48F|FAM73B_ENST00000358369.4_Missense_Mutation_p.L48F|FAM73B_ENST00000474534.1_3'UTR			Q7L4E1	FA73B_HUMAN	family with sequence similarity 73, member B	48						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)	13						GCGGAAAGTCCTCTTTGCCAC	0.647000													11	35					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52425320	52425320	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52425320C>T	ENST00000420323.2	+	62	10128	c.9867C>T	c.(9865-9867)gcC>gcT	p.A3289A		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3354	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TAGACCCAGCCCTGGAGCCAG	0.627000													6	15					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39159259	39159259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39159259C>T	ENST00000359534.3	-	5	1245	c.907G>A	c.(907-909)Gac>Aac	p.D303N		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	303					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity	p.D303Y(1)|p.D303N(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						TTGATGAGGTCGTTGTAGGTC	0.627000													60	190					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22312906	22312906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22312906G>A	ENST00000398793.2	-	17	2499	c.2065C>T	c.(2065-2067)Ccc>Tcc	p.P689S	TOP3B_ENST00000357179.5_Missense_Mutation_p.P689S	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	689					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TAGCAGTAGGGGCACAGCGGG	0.587000													25	98					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32151349	32151349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32151349G>A	ENST00000373672.3	-	29	2423	c.1907C>T	c.(1906-1908)cCa>cTa	p.P636L	COL16A1_ENST00000271069.6_Missense_Mutation_p.P635L|COL16A1_ENST00000373668.3_Missense_Mutation_p.P636L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	636	Nonhelical region 7 (NC7).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGACAGGGCTGGGCACGGCTC	0.637000													50	201					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133654618	133654618	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133654618C>T	ENST00000310926.4	-	13	2087	c.1814_splice	c.e13+1	p.R605_splice	SLCO2A1_ENST00000493729.1_Splice_Site_p.R529_splice	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	605					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GGGCCCTCACCTGTCTCGGAG	0.597000													19	35					0	0	1	0	0
PTH	5741	broad.mit.edu	37	11	13514323	13514323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:13514323G>A	ENST00000282091.1	-	2	194	c.80C>T	c.(79-81)tCt>tTt	p.S27F	PTH_ENST00000529816.1_Missense_Mutation_p.S27F	NM_000315.2	NP_000306.1	P01270	PTHY_HUMAN	parathyroid hormone	27					bone resorption|cAMP metabolic process|cell-cell signaling|cellular calcium ion homeostasis|cellular macromolecule biosynthetic process|induction of apoptosis by hormones|positive regulation of cAMP biosynthetic process|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|skeletal system development		hormone activity|peptide hormone receptor binding			endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(625;0.00116)|Epithelial(150;0.0357)|LUSC - Lung squamous cell carcinoma(625;0.0836)		TTACTTAACAGATTTCCCATC	0.373000													9	31					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60241837	60241837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:60241837C>T	ENST00000269499.5	+	13	2941	c.2523C>T	c.(2521-2523)atC>atT	p.I841I	ZCCHC2_ENST00000586834.1_Silent_p.I520I	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	841					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						GCCTGAGCATCGCATCACCAA	0.507000													26	90					0	0	1	0	0
SPINT4	391253	broad.mit.edu	37	20	44352646	44352646	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44352646C>T	ENST00000279058.3	+	2	260	c.243C>T	c.(241-243)ttC>ttT	p.F81F		NM_178455.1	NP_848550.1	Q6UDR6	SPIT4_HUMAN	serine peptidase inhibitor, Kunitz type 4	81	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			lung(6)|ovary(1)|skin(1)	8		Myeloproliferative disorder(115;0.028)				TTAACAACTTCAAGCTTAAAA	0.403000													24	118					0	0	1	0	0
CAPN7	23473	broad.mit.edu	37	3	15265021	15265021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:15265021C>T	ENST00000253693.2	+	6	931	c.678C>T	c.(676-678)ttC>ttT	p.F226F		NM_014296.2	NP_055111.1	Q9Y6W3	CAN7_HUMAN	calpain 7	226					proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						ATGTTCCTTTCATGAATGTTG	0.318000													29	105					0	0	1	0	0
B3GNT6	192134	broad.mit.edu	37	11	76751273	76751273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76751273C>T	ENST00000533140.1	+	2	816	c.678C>T	c.(676-678)ttC>ttT	p.F226F	B3GNT6_ENST00000354301.5_Silent_p.F226F|B3GNT6_ENST00000421061.1_Silent_p.F137F			Q6ZMB0	B3GN6_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)	226					O-glycan processing, core 3	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)|kidney(2)|lung(4)|prostate(1)	8						ACGACGTGTTCGTGCACACCG	0.677000													7	41					0	0	1	0	0
TMEM156	80008	broad.mit.edu	37	4	39000465	39000465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39000465G>A	ENST00000381938.3	-	2	260	c.153C>T	c.(151-153)tcC>tcT	p.S51S	TMEM156_ENST00000372489.2_5'UTR	NM_024943.1	NP_079219.1	Q8N614	TM156_HUMAN	transmembrane protein 156	51						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						AATTTAAGGAGGAGAGTGAAT	0.333000													19	36					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121981045	121981045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121981045C>T	ENST00000498619.1	+	4	1601	c.1163C>T	c.(1162-1164)tCg>tTg	p.S388L	CASR_ENST00000296154.5_Missense_Mutation_p.S388L|CASR_ENST00000490131.1_Missense_Mutation_p.S388L	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	388					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGCAACAGCTCGACAGCCTTC	0.488000													9	60					0	0	1	0	0
USP30	84749	broad.mit.edu	37	12	109509423	109509423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109509423C>T	ENST00000257548.5	+	5	580	c.487C>T	c.(487-489)Cac>Tac	p.H163Y	USP30_ENST00000392784.2_Missense_Mutation_p.H132Y	NM_032663.3	NP_116052.2	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	163					ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(7)|kidney(1)|large_intestine(1)|liver(2)|lung(11)|prostate(1)|skin(3)|stomach(2)	28						ACAGGATGCTCACGAATTATT	0.493000													23	39					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35544969	35544969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35544969C>T	ENST00000536438.1	-	11	1383	c.1068G>A	c.(1066-1068)agG>agA	p.R356R	FKBP5_ENST00000540787.1_Silent_p.R177R|FKBP5_ENST00000357266.4_Silent_p.R356R|FKBP5_ENST00000539068.1_Silent_p.R356R	NM_001145775.1	NP_001139247.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	356					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						CTTCACCCCTCCTATACAAGC	0.453000													17	223					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167489245	167489245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167489245G>A	ENST00000519204.1	+	6	1245	c.1127G>A	c.(1126-1128)aGa>aAa	p.R376K	TENM2_ENST00000545108.1_Missense_Mutation_p.R497K|TENM2_ENST00000518659.1_Missense_Mutation_p.R497K|TENM2_ENST00000520394.1_Missense_Mutation_p.R265K|TENM2_ENST00000403607.2_Missense_Mutation_p.R330K					teneurin transmembrane protein 2																		TACATAAGAAGAGGACTTCCA	0.408000													36	82					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120009333	120009333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:120009333C>T	ENST00000371311.3	-	1	446	c.192G>A	c.(190-192)gaG>gaA	p.E64E		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	64										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						GCTCACCCTCCTCCTCCCCGA	0.731000													30	41					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41621801	41621801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41621801C>T	ENST00000216237.5	+	12	1518	c.1360C>T	c.(1360-1362)Ctc>Ttc	p.L454F		NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	454					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCCCCAGGTTCTCCTGGATGG	0.592000													16	44					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6181520	6181520	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6181520G>A	ENST00000261405.5	-	9	1340	c.1086C>T	c.(1084-1086)tcC>tcT	p.S362S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	362					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CTCGAGAGAGGGAGGTGCCGG	0.657000													20	44					0	0	1	0	0
TRIM50	135892	broad.mit.edu	37	7	72738612	72738612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72738612C>T	ENST00000333149.2	-	2	374	c.174G>A	c.(172-174)caG>caA	p.Q58Q	TRIM50_ENST00000493498.1_5'UTR|TRIM50_ENST00000453152.1_Silent_p.Q58Q	NM_178125.2	NP_835226.1	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	58						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						CGTCCACCGCCTGCCGGCACA	0.687000											OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	57					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87092147	87092147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87092147G>A	ENST00000265723.4	-	4	324	c.213C>T	c.(211-213)ctC>ctT	p.L71L	ABCB4_ENST00000359206.3_Silent_p.L71L|ABCB4_ENST00000545634.1_Silent_p.L71L|ABCB4_ENST00000358400.3_Silent_p.L71L|ABCB4_ENST00000453593.1_Silent_p.L71L	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	71	ABC transmembrane type-1 1.			IMAIAHGSGLP -> RGSSRVDLQAC (in Ref. 5; CAA84542).	cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TCATGAGGGGGAGACCTGATC	0.378000													18	60					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43269342	43269342	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43269342G>A	ENST00000372585.5	+	7	1068	c.973G>A	c.(973-975)Ggg>Agg	p.G325R	SLC22A7_ENST00000487175.1_3'UTR|SLC22A7_ENST00000372589.3_Missense_Mutation_p.G323R|SLC22A7_ENST00000372574.3_Missense_Mutation_p.G323R	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	325						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity	p.G325W(2)		NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			AGTGGCCGCCGGGGAACGGGT	0.587000													19	35					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2979523	2979523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2979523C>T	ENST00000396946.4	-	6	1127	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	242					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		AGCTTACATTCCTCCTCCATC	0.478000			Mis		DLBCL								32	124					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042352	75042352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75042352G>A	ENST00000343932.4	+	2	336	c.273G>A	c.(271-273)ctG>ctA	p.L91L		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	91					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TGAGCCGCCTGGACACCATCC	0.652000													14	85					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155156135	155156135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155156135G>A	ENST00000357232.3	-	25	8303	c.8304C>T	c.(8302-8304)acC>acT	p.T2768T		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2768					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CATGATCAGAGGTCGTCTGAG	0.418000													45	98					0	0	1	0	0
AGR2	10551	broad.mit.edu	37	7	16839434	16839434	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:16839434C>T	ENST00000419304.2	-	5	416	c.264G>A	c.(262-264)aaG>aaA	p.K88K	AGR2_ENST00000419572.2_Silent_p.K108K|AGR2_ENST00000401412.1_Silent_p.K88K	NM_006408.3	NP_006399.1	O95994	AGR2_HUMAN	anterior gradient 2	88					mucus secretion	endoplasmic reticulum|extracellular region	protein binding			endometrium(2)|lung(1)|prostate(1)|skin(2)	6	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		CAAACACTTTCTTTAAAGCTA	0.289000													5	47					0	0	1	0	0
QTRT1	81890	broad.mit.edu	37	19	10823277	10823277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10823277C>T	ENST00000250237.5	+	7	844	c.834C>T	c.(832-834)ttC>ttT	p.F278F		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	278					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GTGACATGTTCGACTGCGTCT	0.637000													65	166					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434244	72434244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:72434244C>T	ENST00000373517.3	-	1	440	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	NAP1L2_ENST00000536638.1_Intron	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	29					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TCCAGATGTTCCCCGAGCCCT	0.562000													26	21					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206225182	206225182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206225182G>A	ENST00000367126.4	+	1	1207	c.742G>A	c.(742-744)Gac>Aac	p.D248N		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	248					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	GAGGACTTGGGACAGGCCCTC	0.592000													35	84					0	0	1	0	0
C8orf86	389649	broad.mit.edu	37	8	38370017	38370017	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:38370017C>T	ENST00000437935.2	-	2	406	c.387G>A	c.(385-387)tgG>tgA	p.W129*	C8orf86_ENST00000358138.1_Missense_Mutation_p.G187E			Q6ZUL3	CH086_HUMAN	chromosome 8 open reading frame 86	0								p.G187E(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						atgtgcatttccaatcagttc	0.532000													34	85					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16355714	16355714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16355714G>A	ENST00000375692.1	+	13	1275	c.1147G>A	c.(1147-1149)Gac>Aac	p.D383N	CLCNKA_ENST00000331433.4_Missense_Mutation_p.D383N|CLCNKA_ENST00000439316.2_Missense_Mutation_p.D340N|CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000420078.1_Missense_Mutation_p.D383N			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	383					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CGAGGAGCTCGACCCCCAGCA	0.622000													28	68					0	0	1	0	0
OR52A1	23538	broad.mit.edu	37	11	5172952	5172952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5172952G>A	ENST00000380367.1	-	2	1065	c.648C>T	c.(646-648)ttC>ttT	p.F216F	OR52A1_ENST00000328942.1_Silent_p.F216F			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	216					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACAATGTGATGAATGTGAGGT	0.413000													48	99					0	0	1	0	0
TAPBP	6892	broad.mit.edu	37	6	33281164	33281164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33281164G>A	ENST00000434618.2	-	3	644	c.299C>T	c.(298-300)cCc>cTc	p.P100L	TAPBP_ENST00000456592.2_Missense_Mutation_p.P100L|TAPBP_ENST00000426633.2_Missense_Mutation_p.P100L|TAPBP_ENST00000475304.1_Missense_Mutation_p.P100L|TAPBP_ENST00000489157.1_Intron	NM_003190.4|NM_172209.2	NP_003181.3|NP_757346.2	O15533	TPSN_HUMAN	TAP binding protein (tapasin)	100					antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			endometrium(2)|large_intestine(5)|lung(8)|ovary(3)	18						CGCAGAGGCGGGGAGAGGCAC	0.706000													4	31					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	994600	994600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:994600C>T	ENST00000537687.1	+	19	6053	c.5410C>T	c.(5410-5412)Ctc>Ttc	p.L1804F	WNK1_ENST00000530271.2_Missense_Mutation_p.L2042F|WNK1_ENST00000340908.4_Missense_Mutation_p.L1137F|WNK1_ENST00000535572.1_Missense_Mutation_p.L1297F|WNK1_ENST00000315939.6_Missense_Mutation_p.L1544F	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1544					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity	p.L1544I(1)|p.L1804I(1)		breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GGCTTTCTCCCTCTCTGCACC	0.478000													101	395					0	0	1	0	0
NPPA	4878	broad.mit.edu	37	1	11907193	11907193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11907193C>T	ENST00000376480.3	-	2	525	c.427G>A	c.(427-429)Gga>Aga	p.G143R	NPPA-AS1_ENST00000400892.2_RNA|NPPA_ENST00000376476.1_Missense_Mutation_p.G93R|NPPA-AS1_ENST00000446542.1_RNA	NM_006172.3	NP_006163.1	P01160	ANF_HUMAN	natriuretic peptide A	143					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCCCAGTCCGCTCTGGGCT	0.597000													128	304					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53558288	53558288	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:53558288G>A	ENST00000025008.5	-	16	4484	c.3961C>T	c.(3961-3963)Cga>Tga	p.R1321*	RB1CC1_ENST00000539297.1_Nonsense_Mutation_p.R1321*|RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Nonsense_Mutation_p.R1321*	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1321					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AAAGATGTTCGAACATTTTGC	0.313000													18	44					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11053475	11053475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11053475C>T	ENST00000295082.1	+	1	1413	c.923C>T	c.(922-924)tCg>tTg	p.S308L		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	308						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CGCCACTCCTCGGGCCTGCAG	0.637000													6	23					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35802512	35802512	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35802512C>T	ENST00000342694.2	+	11	1978	c.1723C>T	c.(1723-1725)Cag>Tag	p.Q575*		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	575	Protein kinase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	GAGAGATGTTCAGTTCAACCA	0.413000													7	61					0	0	1	0	0
CDT1	81620	broad.mit.edu	37	16	88873061	88873061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:88873061C>T	ENST00000301019.4	+	7	1720	c.1101C>T	c.(1099-1101)gcC>gcT	p.A367A		NM_030928.3	NP_112190.2	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor 1	367					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(80;0.0476)		TGGCCCGGGCCCGCAACCTGA	0.667000													5	17					0	0	1	0	0
TMEM74B	55321	broad.mit.edu	37	20	1162148	1162148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1162148C>T	ENST00000381894.3	-	2	786	c.115G>A	c.(115-117)Ggt>Agt	p.G39S	TMEM74B_ENST00000481747.1_5'UTR	NM_018354.1	NP_060824.1	Q9NUR3	CT046_HUMAN	transmembrane protein 74B	39						integral to membrane	protein binding										GCTTGGGGACCATTGCTCAGT	0.602000													4	53					0	0	1	0	0
DCLRE1C	64421	broad.mit.edu	37	10	14950960	14950960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:14950960G>A	ENST00000453695.2	-	14	1610	c.1166C>T	c.(1165-1167)tCc>tTc	p.S389F	DCLRE1C_ENST00000492201.1_5'UTR|DCLRE1C_ENST00000357717.2_Missense_Mutation_p.S394F|DCLRE1C_ENST00000396817.2_Missense_Mutation_p.S389F|DCLRE1C_ENST00000378242.1_Missense_Mutation_p.S162F|DCLRE1C_ENST00000378258.1_Missense_Mutation_p.S389F|DCLRE1C_ENST00000378246.2_Missense_Mutation_p.S394F|DCLRE1C_ENST00000378278.2_Missense_Mutation_p.S509F|DCLRE1C_ENST00000378255.1_Missense_Mutation_p.S389F|DCLRE1C_ENST00000378254.1_Missense_Mutation_p.S389F|DCLRE1C_ENST00000378249.1_Missense_Mutation_p.S394F|DCLRE1C_ENST00000378289.4_Intron	NM_001033855.1	NP_001029027.1	Q96SD1	DCR1C_HUMAN	DNA cross-link repair 1C	509					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	17						CACTGTGGAGGAAGGGAAGTT	0.458000								Non-homologous end-joining					13	36					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130308020	130308020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130308020G>A	ENST00000358511.6	+	11	4243	c.4212G>A	c.(4210-4212)ggG>ggA	p.G1404G	COL6A6_ENST00000453409.2_Silent_p.G1404G	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1404	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GACCACCAGGGAAAAGGGTGA	0.433000													9	26					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17941319	17941319	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17941319G>A	ENST00000458235.1	-	22	3188	c.3089C>T	c.(3088-3090)cCc>cTc	p.P1030L	JAK3_ENST00000534444.1_Missense_Mutation_p.P1030L|JAK3_ENST00000527670.1_Missense_Mutation_p.P1030L	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	1030	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						CACGGCCGAGGGGCTGCAGCT	0.617000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								7	17					0	0	1	0	0
ISYNA1	51477	broad.mit.edu	37	19	18547253	18547253	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18547253A>T	ENST00000545187.1	-	3	482	c.196T>A	c.(196-198)Tct>Act	p.S66T	ISYNA1_ENST00000457269.3_Missense_Mutation_p.S162T|ISYNA1_ENST00000338128.7_Missense_Mutation_p.S216T|ISYNA1_ENST00000317018.6_Missense_Mutation_p.S14T|ISYNA1_ENST00000578963.1_Missense_Mutation_p.S88T			Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	216					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			breast(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	12						CCCGCGCTAGACCGGAAGTCT	0.587000													39	95					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55266593	55266593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55266593C>T	ENST00000340465.2	+	9	1213	c.1127C>T	c.(1126-1128)tCc>tTc	p.S376F		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	376						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TACAGAACTTCCAGAATATCA	0.358000													16	68					0	0	1	0	0
IL12RB2	3595	broad.mit.edu	37	1	67861377	67861377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:67861377G>A	ENST00000262345.1	+	16	2834	c.2194G>A	c.(2194-2196)Gga>Aga	p.G732R	IL12RB2_ENST00000371000.1_3'UTR|IL12RB2_ENST00000465396.1_3'UTR|IL12RB2_ENST00000541374.1_3'UTR|IL12RB2_ENST00000544434.1_Missense_Mutation_p.G646R	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	732					positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						AAGGGAAAAAGGAATCCAAGG	0.532000													18	52					0	0	1	0	0
SLC29A3	55315	broad.mit.edu	37	10	73122195	73122195	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73122195T>G	ENST00000373189.5	+	6	1310	c.1258T>G	c.(1258-1260)Tcc>Gcc	p.S420A	SLC29A3_ENST00000469204.1_3'UTR	NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	420					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						ACTCCTCAGCTCCCTGCTGGG	0.632000													30	90					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21462834	21462834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:21462834G>A	ENST00000281523.2	-	8	1578	c.1060C>T	c.(1060-1062)Ccc>Tcc	p.P354S		NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	354						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						AGACTGAAGGGGGAACTCAct	0.557000													6	24					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136564845	136564845	+	Silent	SNP	C	C	T	rs150640616		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136564845C>T	ENST00000264162.2	-	9	4036	c.4026G>A	c.(4024-4026)acG>acA	p.T1342T		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1342	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGGCCTGTTCGTGTTGTTGA	0.522000													47	79					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6428018	6428018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6428018C>T	ENST00000449001.2	+	11	1781	c.1287C>T	c.(1285-1287)ctC>ctT	p.L429L	PLEKHG6_ENST00000396988.3_Silent_p.L461L|PLEKHG6_ENST00000011684.7_Silent_p.L461L|PLEKHG6_ENST00000536531.1_Silent_p.L461L	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	461	PH.				regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						TGGAGAAGCTCGTGTGCCAAC	0.582000													12	46					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48381938	48381938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48381938C>T	ENST00000224600.4	-	4	3824	c.3711G>A	c.(3709-3711)gtG>gtA	p.V1237V		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1237					lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GGCTCCGCTTCACCCTCAGCT	0.647000													4	20					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23549177	23549177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23549177G>A	ENST00000262710.1	-	6	1868	c.1541C>T	c.(1540-1542)gCc>gTc	p.A514V	ACIN1_ENST00000605057.1_Missense_Mutation_p.A456V|ACIN1_ENST00000555053.1_Missense_Mutation_p.A514V|ACIN1_ENST00000457657.1_Missense_Mutation_p.A474V	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	514					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ATCCTTCTGGGCTGAGTAGTC	0.493000													61	94					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97427263	97427263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97427263C>T	ENST00000377075.2	+	1	625	c.527C>T	c.(526-528)cCt>cTt	p.P176L		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	176					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GTGGAGGAGCCTGGGAGGTTC	0.602000													110	257					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685672	125685672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:125685672C>T	ENST00000371126.1	-	1	1162	c.920G>A	c.(919-921)cGg>cAg	p.R307Q		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	307										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CACATTATCCCGGAAGTAGGG	0.582000													34	26					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40345098	40345098	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40345098A>G	ENST00000280871.4	-	4	1045	c.995T>C	c.(994-996)cTa>cCa	p.L332P	SLC2A13_ENST00000380858.1_Missense_Mutation_p.L332P	NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	332						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				GAACATTTGTAGGCCACAACC	0.373000										HNSCC(50;0.14)			8	65					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584932	82584932	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82584932C>T	ENST00000423517.2	-	5	5674	c.5337G>A	c.(5335-5337)ttG>ttA	p.L1779L	PCLO_ENST00000333891.8_Silent_p.L1779L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1710					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTTCCTCTCTCAATTCTTCTT	0.393000													39	86					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27444208	27444208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27444208C>T	ENST00000264705.4	+	3	507	c.345C>T	c.(343-345)ggC>ggT	p.G115G	CAD_ENST00000403525.1_Silent_p.G115G	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	115	GATase (Glutamine amidotransferase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCATCCCTGGCTTGCAAGGTA	0.567000													10	19					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9943624	9943624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9943624G>A	ENST00000396573.2	-	6	1626	c.1317C>T	c.(1315-1317)ttC>ttT	p.F439F	GRIN2A_ENST00000535259.1_Silent_p.F282F|GRIN2A_ENST00000404927.2_Silent_p.F439F|GRIN2A_ENST00000562109.1_Silent_p.F439F|GRIN2A_ENST00000330684.3_Silent_p.F439F|GRIN2A_ENST00000396575.2_Silent_p.F439F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	439					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGATTTTGACGAACTTCCGAC	0.502000													30	74					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40935959	40935959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40935959C>T	ENST00000246914.5	+	3	817	c.796C>T	c.(796-798)Ctg>Ttg	p.L266L		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	266	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCCCAGGTACCTGAGGCGGTT	0.672000													5	18					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034594	52034594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52034594C>T	ENST00000346477.3	-	2	315	c.247G>A	c.(247-249)Gaa>Aaa	p.E83K	SIGLEC6_ENST00000391797.3_Missense_Mutation_p.E83K|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.E47K|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.E83K|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.E83K|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.E83K	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	83	Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGCACTTCTTCGTCTGGGTCG	0.582000													31	92					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29287358	29287358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29287358G>A	ENST00000266943.6	-	3	888	c.519C>T	c.(517-519)gaC>gaT	p.D173D	SLC46A3_ENST00000380814.4_Silent_p.D173D	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	173					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		CAAGTAGAAAGTCAATGATAG	0.368000													27	47					0	0	1	0	0
ZNF138	7697	broad.mit.edu	37	7	64292248	64292248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:64292248C>T	ENST00000359735.3	+	4	804	c.457C>T	c.(457-459)Ctt>Ttt	p.L153F	ZNF138_ENST00000307355.7_Missense_Mutation_p.L210F|ZNF138_ENST00000430838.2_3'UTR|ZNF138_ENST00000397136.2_Missense_Mutation_p.L153F|ZNF138_ENST00000440155.2_Missense_Mutation_p.L184F|ZNF138_ENST00000440598.1_3'UTR|ZNF138_ENST00000437743.1_Missense_Mutation_p.L178F	NM_001271637.1|NM_001271639.1	NP_001258566.1|NP_001258568.1	B4DP87	B4DP87_HUMAN	zinc finger protein 138	184					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(2)|stomach(1)	7		Lung NSC(55;0.0795)|all_lung(88;0.18)				GTCCACAAACCTTTCTAAACC	0.343000													15	40					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951115	38951115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38951115C>T	ENST00000355481.4	+	20	2592	c.2461C>T	c.(2461-2463)Cat>Tat	p.H821Y	RYR1_ENST00000359596.3_Missense_Mutation_p.H821Y|RYR1_ENST00000360985.3_Missense_Mutation_p.H821Y	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	821					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGAGCGACTCCATCTTGAACC	0.647000													40	120					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42828080	42828080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42828080C>T	ENST00000314073.5	+	11	2511	c.2335C>T	c.(2335-2337)Cta>Tta	p.L779L	GLTSCR1L_ENST00000394168.1_Silent_p.L779L					GLTSCR1-like																		ATGCCTGCTCCTAGAAGATGC	0.383000													52	110					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111779739	111779739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111779739G>A	ENST00000261726.6	+	21	3695	c.3541G>A	c.(3541-3543)Gag>Aag	p.E1181K		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1181						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CGAGGAGAAGGAGGCACTGCG	0.642000													7	89					0	0	1	0	0
SMAD6	4091	broad.mit.edu	37	15	67073660	67073660	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:67073660C>T	ENST00000288840.5	+	4	2309	c.1278C>T	c.(1276-1278)gtC>gtT	p.V426V	SMAD6_ENST00000338426.4_Silent_p.V165V	NM_005585.4	NP_005576.3	O43541	SMAD6_HUMAN	SMAD family member 6	426	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			lung(1)|skin(1)	2						GCGCCCTGGTCGTGCGCAAGG	0.731000													10	37					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55976628	55976628	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55976628G>A	ENST00000263923.4	-	9	1492	c.1197C>T	c.(1195-1197)atC>atT	p.I399I		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	399	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GATTGGTAAGGATGACAGTGT	0.423000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			31	67					0	0	1	0	0
SGOL1	151648	broad.mit.edu	37	3	20216529	20216529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:20216529G>A	ENST00000412997.1	-	6	845	c.494C>T	c.(493-495)cCt>cTt	p.P165L	SGOL1_ENST00000442720.1_Intron|SGOL1_ENST00000437051.1_Missense_Mutation_p.P165L|SGOL1-AS1_ENST00000441442.1_RNA|SGOL1-AS1_ENST00000448208.1_RNA|SGOL1_ENST00000443724.1_Missense_Mutation_p.P165L|SGOL1_ENST00000412868.1_Missense_Mutation_p.P165L|SGOL1_ENST00000417364.1_Missense_Mutation_p.P165L|SGOL1_ENST00000429446.3_Intron|SGOL1_ENST00000452020.1_Intron|SGOL1_ENST00000425061.1_Missense_Mutation_p.P165L|SGOL1_ENST00000419233.2_Missense_Mutation_p.P165L|SGOL1_ENST00000263753.4_Missense_Mutation_p.P165L|SGOL1_ENST00000306698.2_Intron|SGOL1_ENST00000421451.1_Missense_Mutation_p.P165L|SGOL1_ENST00000383774.1_Missense_Mutation_p.P165L	NM_001199251.1	NP_001186180.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	165	Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						TGTGTCTTGAGGAATAGTAGG	0.308000													22	43					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043742	20043742	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20043742C>T	ENST00000570682.1	-	2	677	c.377G>A	c.(376-378)aGg>aAg	p.R126K		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	126						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						AGCGATATACCTGTCAATGGT	0.502000													24	73					0	0	1	0	0
RIC3	79608	broad.mit.edu	37	11	8148302	8148302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8148302G>A	ENST00000396677.2	-	2	87	c.88C>T	c.(88-90)Cga>Tga	p.R30*	RIC3_ENST00000539720.1_Nonsense_Mutation_p.R143*|RIC3_ENST00000530060.1_5'UTR|RIC3_ENST00000425599.2_Intron|RIC3_ENST00000343202.4_Nonsense_Mutation_p.R191*|RIC3_ENST00000335425.7_Intron|RIC3_ENST00000309737.6_Nonsense_Mutation_p.R192*			Q7Z5B4	RIC3_HUMAN	RIC3 acetylcholine receptor chaperone	192						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		GTGATTTCTCGGAGCTGATGT	0.443000													18	56					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41525904	41525904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41525904C>T	ENST00000396942.1	-	39	5358	c.5275G>A	c.(5275-5277)Gag>Aag	p.E1759K	ANK1_ENST00000289734.7_Missense_Mutation_p.E1759K|ANK1_ENST00000347528.4_Missense_Mutation_p.E1759K|ANK1_ENST00000379758.2_Missense_Mutation_p.E1759K|ANK1_ENST00000352337.4_Missense_Mutation_p.E1759K|ANK1_ENST00000265709.8_Missense_Mutation_p.E1800K|ANK1_ENST00000396945.1_Missense_Mutation_p.E1759K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1759	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CACGTGTGCTCACTTACAGAC	0.592000													25	57					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228525070	228525070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228525070G>A	ENST00000570156.2	+	77	19731	c.19657G>A	c.(19657-19659)Gat>Aat	p.D6553N	OBSCN_ENST00000366707.4_Missense_Mutation_p.D3230N|OBSCN_ENST00000422127.1_Missense_Mutation_p.D5596N|OBSCN_ENST00000284548.11_Missense_Mutation_p.D5596N|OBSCN_ENST00000366709.4_Missense_Mutation_p.D2715N	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5596	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGAGGACGGCGATGCCCGAGG	0.642000													4	12					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45475276	45475276	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:45475276C>A	ENST00000361462.2	+	5	2893	c.2710C>A	c.(2710-2712)Cga>Aga	p.R904R	KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Silent_p.R904R|FAM179B_ENST00000382233.2_Silent_p.R904R			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	904							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						GCCATCTTCCCGACGAGGTCT	0.413000													40	149					9.62906e-15	9.67881e-15	1	1	0
MUC16	94025	broad.mit.edu	37	19	9069821	9069821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9069821G>A	ENST00000397910.4	-	3	17828	c.17625C>T	c.(17623-17625)acC>acT	p.T5875T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5877	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAGGGTAAGGGTAGCCTGTG	0.493000													36	94					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175046766	175046766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175046766C>T	ENST00000239462.4	+	2	325	c.212C>T	c.(211-213)tCg>tTg	p.S71L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	71					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GATGGGGCTTCGCTCTTGGCC	0.587000													11	31					0	0	1	0	0
ATG3	64422	broad.mit.edu	37	3	112251591	112251591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112251591G>A	ENST00000283290.5	-	12	1334	c.900C>T	c.(898-900)gtC>gtT	p.V300V	ATG3_ENST00000402314.2_3'UTR	NM_022488.3	NP_071933.2	Q9NT62	ATG3_HUMAN	autophagy related 3	300					autophagic vacuole assembly|mitochondrial fragmentation involved in apoptosis|protein targeting to membrane|protein ubiquitination	cytoplasmic ubiquitin ligase complex|cytosol	Atg12 ligase activity|Atg8 ligase activity|enzyme binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(3)	9						TTGTTGGAATGACAGCTTGTA	0.284000													32	56					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597061	136597061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136597061C>T	ENST00000531224.1	-	5	1854	c.1602G>A	c.(1600-1602)agG>agA	p.R534R	BCLAF1_ENST00000527536.1_Silent_p.R534R|BCLAF1_ENST00000527759.1_Silent_p.R532R|BCLAF1_ENST00000392348.2_Silent_p.R532R|BCLAF1_ENST00000530767.1_Silent_p.R361R|BCLAF1_ENST00000353331.4_Silent_p.R532R	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	534					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding	p.R534S(1)		haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCATTTTGATCCTAAGTGGGC	0.433000													45	264					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52522557	52522557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52522557C>T	ENST00000345716.4	+	16	3183	c.3049C>T	c.(3049-3051)Ccc>Tcc	p.P1017S	NISCH_ENST00000479054.1_Missense_Mutation_p.P1017S	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	1017					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CGCCAAGACCCCCGGGACGGG	0.677000													19	38					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2714298	2714298	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2714298G>A	ENST00000399655.1	+	23	3277	c.3012G>A	c.(3010-3012)agG>agA	p.R1004R	CACNA1C_ENST00000347598.4_Silent_p.R1024R|CACNA1C_ENST00000399591.1_Silent_p.R1004R|CACNA1C_ENST00000480911.1_Silent_p.R1004R|CACNA1C_ENST00000344100.3_Silent_p.R1004R|CACNA1C_ENST00000399597.1_Silent_p.R1004R|CACNA1C_ENST00000335762.5_Silent_p.R1029R|CACNA1C_ENST00000399595.1_Silent_p.R1004R|CACNA1C_ENST00000399603.1_Silent_p.R1004R|CACNA1C_ENST00000399617.1_Silent_p.R1004R|CACNA1C_ENST00000399606.1_Silent_p.R1024R|CACNA1C_ENST00000399621.1_Silent_p.R1004R|CACNA1C_ENST00000399601.1_Silent_p.R1004R|CACNA1C-AS3_ENST00000543559.1_RNA|CACNA1C_ENST00000399638.1_Silent_p.R1004R|CACNA1C_ENST00000399649.1_Silent_p.R1004R|CACNA1C_ENST00000399644.1_Silent_p.R1004R|CACNA1C_ENST00000399629.1_Silent_p.R1004R|CACNA1C_ENST00000327702.7_Silent_p.R1004R|CACNA1C_ENST00000399634.1_Silent_p.R1004R|CACNA1C_ENST00000399637.1_Silent_p.R1004R|CACNA1C_ENST00000406454.3_Silent_p.R1004R|CACNA1C_ENST00000402845.3_Silent_p.R1004R|CACNA1C_ENST00000399641.1_Silent_p.R1004R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1024					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GAGTACTCAGGCCCCTGAGGG	0.592000													7	50					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8235575	8235575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8235575C>T	ENST00000520004.1	-	3	608	c.344G>A	c.(343-345)cGa>cAa	p.R115Q	SGK223_ENST00000330777.4_Missense_Mutation_p.R115Q			Q86YV5	SG223_HUMAN		115							ATP binding|non-membrane spanning protein tyrosine kinase activity										GCCAGGGGCTCGTCTCCAGAT	0.547000													30	83					0	0	1	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43802323	43802323	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43802323C>T	ENST00000291532.3	-	9	1758	c.803G>A	c.(802-804)tGg>tAg	p.W268*	TMPRSS3_ENST00000474596.1_5'UTR|TMPRSS3_ENST00000433957.2_Nonsense_Mutation_p.W268*|TMPRSS3_ENST00000398397.3_Nonsense_Mutation_p.W268*|TMPRSS3_ENST00000380399.1_Nonsense_Mutation_p.W352*|TMPRSS3_ENST00000398405.1_Nonsense_Mutation_p.W266*	NM_032404.2	NP_115780.1	P57727	TMPS3_HUMAN	transmembrane protease, serine 3	268	Peptidase S1.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						CTGGATGGTCCATGACTTGGG	0.498000													14	39					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20406640	20406640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20406640C>T	ENST00000222573.3	+	3	903	c.219C>T	c.(217-219)ttC>ttT	p.F73F	ITGB8_ENST00000537992.1_5'UTR	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	73					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						AACAGGATTTCATTTCAGGTG	0.303000													39	88					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40351347	40351347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40351347G>A	ENST00000310169.2	+	4	953	c.814G>A	c.(814-816)Gga>Aga	p.G272R		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	272					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	GGTCTCCCTGGGAGTGACCAT	0.502000													79	220					0	0	1	0	0
OR2Y1	134083	broad.mit.edu	37	5	180166987	180166987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180166987C>T	ENST00000307832.2	-	1	112	c.72G>A	c.(70-72)gaG>gaA	p.E24E		NM_001001657.1	NP_001001657.1	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y, member 1	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGGATGGGCTCCAGTTGCG	0.473000													11	32					0	0	1	0	0
RSPO3	84870	broad.mit.edu	37	6	127476394	127476394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:127476394G>A	ENST00000356698.4	+	4	1034	c.445G>A	c.(445-447)Gag>Aag	p.E149K	RSPO3_ENST00000485757.1_3'UTR|RSPO3_ENST00000368317.3_Missense_Mutation_p.E149K	NM_032784.3	NP_116173.2	Q9BXY4	RSPO3_HUMAN	R-spondin 3	149	TSP type-1.					extracellular region	heparin binding		PTPRK/RSPO3(10)	breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17				GBM - Glioblastoma multiforme(226;0.0555)		AGTGCACTGTGAGGTCAGTGA	0.428000													57	96					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207640026	207640026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207640026G>A	ENST00000367057.3	+	2	403	c.214G>A	c.(214-216)Gat>Aat	p.D72N	CR2_ENST00000367058.3_Missense_Mutation_p.D72N|CR2_ENST00000458541.2_Missense_Mutation_p.D72N|CR2_ENST00000367059.3_Missense_Mutation_p.D72N	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	72	Sushi 1.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						AGACAAAGTGGATGGAACCTG	0.413000													48	109					0	0	1	0	0
NR0B2	8431	broad.mit.edu	37	1	27238410	27238410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27238410C>T	ENST00000254227.3	-	2	725	c.700G>A	c.(700-702)Gac>Aac	p.D234N		NM_021969.2	NP_068804.1	Q15466	NR0B2_HUMAN	nuclear receptor subfamily 0, group B, member 2	234					cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity			NS(1)|large_intestine(1)|lung(3)	5		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		AAGAAGAGGTCCCCAAGCAGG	0.597000													34	130					0	0	1	0	0
ERLIN1	10613	broad.mit.edu	37	10	101912014	101912014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101912014G>A	ENST00000421367.2	-	11	3628	c.921C>T	c.(919-921)ttC>ttT	p.F307F	ERLIN1_ENST00000407654.3_Silent_p.F307F	NM_001100626.1|NM_006459.3	NP_001094096.1|NP_006450.2	O75477	ERLN1_HUMAN	ER lipid raft associated 1	305					ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding						Colorectal(252;0.234)		Epithelial(162;3.85e-10)|all cancers(201;3.25e-08)		AGGAGTCCACGAACATGTTAG	0.458000													17	76					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71712665	71712665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71712665G>A	ENST00000356340.3	+	37	2589	c.2053G>A	c.(2053-2055)Ggg>Agg	p.G685R	COL13A1_ENST00000517713.1_Missense_Mutation_p.G636R|COL13A1_ENST00000398973.3_Missense_Mutation_p.G659R|COL13A1_ENST00000398972.3_Missense_Mutation_p.G671R|COL13A1_ENST00000357811.3_Missense_Mutation_p.G651R|COL13A1_ENST00000398966.3_Missense_Mutation_p.G663R|COL13A1_ENST00000522165.1_Missense_Mutation_p.G654R|COL13A1_ENST00000398971.3_Missense_Mutation_p.G670R|COL13A1_ENST00000520133.1_Intron|COL13A1_ENST00000520267.1_Missense_Mutation_p.G613R|COL13A1_ENST00000398968.3_Missense_Mutation_p.G666R|COL13A1_ENST00000398978.3_Missense_Mutation_p.G685R|COL13A1_ENST00000398974.3_Missense_Mutation_p.G673R|COL13A1_ENST00000398964.3_Missense_Mutation_p.G656R|COL13A1_ENST00000354547.3_Missense_Mutation_p.G663R|COL13A1_ENST00000398969.3_Missense_Mutation_p.G613R			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	685	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AGGCTCTAGAGGGCCTAAAGG	0.428000													21	64					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	20998675	20998675	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20998675C>T	ENST00000247986.2	-	12	2788	c.2478G>A	c.(2476-2478)gaG>gaA	p.E826E	KIF17_ENST00000400463.3_Silent_p.E826E|KIF17_ENST00000490034.1_5'UTR|KIF17_ENST00000375044.1_Silent_p.E726E			Q9P2E2	KIF17_HUMAN	kinesin family member 17	826					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TGATCTCCACCTCTGCTGCCC	0.557000													9	27					0	0	1	0	0
HHATL	57467	broad.mit.edu	37	3	42739045	42739045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42739045G>A	ENST00000441594.1	-	7	1081	c.820C>T	c.(820-822)Ccc>Tcc	p.P274S	HHATL_ENST00000310417.5_Missense_Mutation_p.P274S	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	274					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		AGGTCGCTGGGGATAGTGAGG	0.612000													43	89					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178140442	178140442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178140442G>A	ENST00000335815.2	-	5	634	c.437C>T	c.(436-438)tCa>tTa	p.S146L		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	146					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		GTGGGTGGCTGAAACTATCTG	0.363000													69	126					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022865	76022865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76022865C>T	ENST00000393004.2	-	5	2904	c.2683G>A	c.(2683-2685)Ggg>Agg	p.G895R	FILIP1_ENST00000237172.7_Missense_Mutation_p.G895R|FILIP1_ENST00000370020.1_Missense_Mutation_p.G796R|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	895										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CCTGGGTGCCCTGGACTGGAA	0.532000													9	100					0	0	1	0	0
LGMN	5641	broad.mit.edu	37	14	93185157	93185157	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93185157G>A	ENST00000393218.2	-	4	508	c.171C>T	c.(169-171)caC>caT	p.H57H	LGMN_ENST00000334869.4_Silent_p.H57H|LGMN_ENST00000555699.1_Silent_p.H57H|LGMN_ENST00000557434.1_Silent_p.H57H	NM_001008530.2	NP_001008530.1	Q99538	LGMN_HUMAN	legumain	57					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|skin(2)	18		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		TCCCATTGCGGTGAATGATCT	0.483000													27	81					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230924019	230924019	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230924019T>C	ENST00000295190.4	-	2	508	c.50A>G	c.(49-51)aAa>aGa	p.K17R		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	17						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		CTTTTTGTCTTTGGGGCCATC	0.408000													5	69					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10222305	10222305	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10222305C>T	ENST00000418404.3	-	26	3703	c.3540G>A	c.(3538-3540)agG>agA	p.R1180R	MYH13_ENST00000570743.1_Silent_p.R1180R|MYH13_ENST00000252172.4_Silent_p.R1180R			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1180					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCTCCAGGTCCCTGCGCATTT	0.582000													94	77					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140362060	140362060	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140362060C>T	ENST00000532602.1	+	3	3487	c.2453_splice	c.e3-1	p.S818_splice	PCDHA4_ENST00000512229.2_Splice_Site_p.S815_splice|PCDHA5_ENST00000529859.1_Splice_Site_p.S804_splice|PCDHA6_ENST00000529310.1_Splice_Site_p.S818_splice|PCDHA7_ENST00000525929.1_Splice_Site_p.S805_splice|PCDHA8_ENST00000531613.1_Splice_Site_p.S818_splice|PCDHA5_ENST00000529619.1_Splice_Site_p.S804_splice|PCDHA4_ENST00000530339.1_Splice_Site_p.S815_splice|PCDHA6_ENST00000527624.1_Splice_Site_p.S554_splice|PCDHAC2_ENST00000289269.5_Splice_Site_p.S875_splice|PCDHA12_ENST00000398631.2_Splice_Site_p.S809_splice|PCDHAC1_ENST00000253807.2_Splice_Site_p.S831_splice|PCDHA10_ENST00000506939.2_Splice_Site_p.S553_splice|PCDHA10_ENST00000307360.5_Splice_Site_p.S816_splice|PCDHA1_ENST00000504120.2_Splice_Site_p.S818_splice|PCDHA11_ENST00000398640.2_Splice_Site_p.S817_splice|PCDHA13_ENST00000289272.2_Splice_Site_p.S818_splice|PCDHA13_ENST00000409494.1_Splice_Site_p.S818_splice|PCDHA3_ENST00000522353.2_Splice_Site_p.S818_splice|PCDHA1_ENST00000394633.3_Splice_Site_p.S554_splice|PCDHA2_ENST00000526136.1_Splice_Site_p.S816_splice	NM_031857.1	NP_114063.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTATTCAGCTCTGTGCACC	0.502000													28	56					0	0	1	0	0
OTX2	5015	broad.mit.edu	37	14	57268695	57268695	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:57268695G>A	ENST00000339475.5	-	5	928	c.652C>T	c.(652-654)Cac>Tac	p.H218Y	OTX2_ENST00000555006.1_Missense_Mutation_p.H210Y|OTX2_ENST00000408990.3_Missense_Mutation_p.H210Y|OTX2_ENST00000554788.1_3'UTR	NM_001270523.1|NM_001270524.1|NM_001270525.1|NM_021728.3	NP_001257452.1|NP_001257453.1|NP_001257454.1|NP_068374.1	P32243	OTX2_HUMAN	orthodenticle homeobox 2	210					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	19	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					GGAAGCTGGTGATGCATAGGG	0.522000													20	47					0	0	1	0	0
SPATA19	219938	broad.mit.edu	37	11	133712390	133712390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:133712390C>T	ENST00000299140.3	-	5	481	c.427G>A	c.(427-429)Gtg>Atg	p.V143M	SPATA19_ENST00000532889.1_Missense_Mutation_p.V143M	NM_174927.1	NP_777587.1	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19	143					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane				cervix(1)|endometrium(2)|large_intestine(2)|lung(5)|prostate(1)	11	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		CTTCGTCTCACCTGCTCTATT	0.532000													40	93					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18030129	18030129	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18030129C>T	ENST00000205890.5	+	6	4229	c.3891C>T	c.(3889-3891)ctC>ctT	p.L1297L		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1297	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TTGCAAATCTCGCCTTCGCCA	0.547000													79	91					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271920	22271920	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22271920G>A	ENST00000594947.1	+	4	1512	c.1368G>A	c.(1366-1368)gaG>gaA	p.E456E		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATACTGGAGAGAAACCCTACA	0.393000													24	55					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122387215	122387215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:122387215G>A	ENST00000264357.5	+	3	622	c.330G>A	c.(328-330)atG>atA	p.M110I	GRIA3_ENST00000542149.1_Missense_Mutation_p.M110I|GRIA3_ENST00000371256.5_Missense_Mutation_p.M110I|GRIA3_ENST00000371251.1_Missense_Mutation_p.M110I|GRIA3_ENST00000541091.1_Missense_Mutation_p.M94I|GRIA3_ENST00000479118.1_3'UTR	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	110					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	AGATGTCAATGAACACCCTGA	0.498000													73	50					0	0	1	0	0
SIK2	23235	broad.mit.edu	37	11	111572220	111572220	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111572220C>T	ENST00000304987.3	+	6	821	c.648C>T	c.(646-648)ccC>ccT	p.P216P		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	216	Protein kinase.				intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						GAGCTCTGCCCTTTGATGGAC	0.423000													20	201					0	0	1	0	0
HOXA3	3200	broad.mit.edu	37	7	27148074	27148074	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27148074T>C	ENST00000396352.4	-	3	991	c.792A>G	c.(790-792)ccA>ccG	p.P264P	HOXA-AS2_ENST00000518088.1_RNA|HOXA3_ENST00000317201.2_Silent_p.P264P	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	264					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						GGCTGCGACTTGGAGACTGGC	0.602000													50	129					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885727	29885727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29885727G>A	ENST00000310624.6	+	4	2131	c.2098G>A	c.(2098-2100)Gaa>Aaa	p.E700K		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	706	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						CCCAGTGAAGGAAGAAGCAAA	0.557000													53	145					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140596022	140596022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140596022C>T	ENST00000341948.4	+	1	2514	c.2327C>T	c.(2326-2328)cCc>cTc	p.P776L		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		776					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.P776H(1)		NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTTCCCTCCCCAGTGCCCT	0.468000													55	118					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314322	54314322	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54314322C>T	ENST00000324134.6	-	3	759	c.591G>A	c.(589-591)gaG>gaA	p.E197E	NLRP12_ENST00000354278.3_Silent_p.E197E|NLRP12_ENST00000391772.1_Silent_p.E197E|NLRP12_ENST00000351894.4_Silent_p.E197E|NLRP12_ENST00000391775.3_Silent_p.E197E|NLRP12_ENST00000535162.1_Silent_p.E197E|NLRP12_ENST00000345770.5_Silent_p.E197E|NLRP12_ENST00000391773.1_Silent_p.E197E	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	197					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAAAGAGGGTCTCTATCTTGA	0.637000													7	112					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92523184	92523184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92523184G>A	ENST00000298047.6	+	7	4428	c.4411G>A	c.(4411-4413)Gag>Aag	p.E1471K	FAT3_ENST00000525166.1_Missense_Mutation_p.E1321K|FAT3_ENST00000409404.2_Missense_Mutation_p.E1471K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1471	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACAATTTCCGAGGATGTGCT	0.423000										TCGA Ovarian(4;0.039)			21	99					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099913	133099913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133099913G>A	ENST00000515826.1	+	3	1481	c.1358G>A	c.(1357-1359)gGg>gAg	p.G453E	TMEM108_ENST00000321871.6_Missense_Mutation_p.G453E|TMEM108_ENST00000393130.3_Missense_Mutation_p.G453E|TMEM108_ENST00000508711.1_Intron			Q6UXF1	TM108_HUMAN	transmembrane protein 108	453						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GTGGCCGAGGGGGACAAACCG	0.612000													12	91					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73748388	73748388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73748388G>A	ENST00000200181.3	+	31	4114	c.3927G>A	c.(3925-3927)gaG>gaA	p.E1309E	ITGB4_ENST00000449880.2_Silent_p.E1309E|ITGB4_ENST00000339591.3_Silent_p.E1309E|ITGB4_ENST00000450894.3_Silent_p.E1309E|GALK1_ENST00000225614.2_Intron|ITGB4_ENST00000579662.1_Silent_p.E1309E	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1309	Fibronectin type-III 2.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGGGCCTGAGCGGGAGGCCA	0.672000													30	90					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8176871	8176871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8176871G>A	ENST00000600128.1	-	31	4365	c.3951C>T	c.(3949-3951)ttC>ttT	p.F1317F	FBN3_ENST00000601739.1_Silent_p.F1317F|FBN3_ENST00000270509.2_Silent_p.F1317F			Q75N90	FBN3_HUMAN	fibrillin 3	1317	EGF-like 19; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CGTGACATTCGAAGCCATCCC	0.637000													35	60					0	0	1	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18165325	18165325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:18165325C>T	ENST00000278816.2	+	10	2714	c.2064C>T	c.(2062-2064)ggC>ggT	p.G688G	CSRP2BP_ENST00000489634.2_Silent_p.G560G|CSRP2BP_ENST00000377681.2_Silent_p.G687G|CSRP2BP_ENST00000435364.2_Silent_p.G688G			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	688	N-acetyltransferase.				histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						TTGCCTTTGGCTTCATGGTTC	0.408000													42	86					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42173354	42173354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42173354G>A	ENST00000320955.6	-	13	2763	c.2536C>T	c.(2536-2538)Cct>Tct	p.P846S		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	846					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCATCCCCAGGGCCAGGGTGG	0.602000													23	33					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100796699	100796699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:100796699C>T	ENST00000358544.2	+	43	8122	c.8011C>T	c.(8011-8013)Cca>Tca	p.P2671S	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.P2646S	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2671					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCACAAATCCCCACAGGTATT	0.473000													24	105					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045156	87045156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87045156C>T	ENST00000370563.3	+	13	2284	c.2242C>T	c.(2242-2244)Ccc>Tcc	p.P748S	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	748						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CCCAAGCCTTCCCTTGCCTGA	0.468000													67	134					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123444423	123444423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123444423G>A	ENST00000542678.1	-	2	3198	c.360C>T	c.(358-360)ttC>ttT	p.F120F	ABCB9_ENST00000344275.7_Silent_p.F120F|ABCB9_ENST00000392439.3_Silent_p.F120F|ABCB9_ENST00000442833.2_Silent_p.F120F|ABCB9_ENST00000442028.2_Silent_p.F120F|ABCB9_ENST00000346530.5_Silent_p.F120F|ABCB9_ENST00000540285.1_Silent_p.F120F|ABCB9_ENST00000280560.8_Silent_p.F120F			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	120					positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		ACGTCCACACGAACAGGGCCC	0.657000													10	21					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664151	44664151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44664151G>A	ENST00000454036.1	+	3	401	c.325G>A	c.(325-327)Ggt>Agt	p.G109S	SLC12A5_ENST00000243964.3_Missense_Mutation_p.G86S|SLC12A5_ENST00000539566.1_Missense_Mutation_p.G86S|SLC12A5_ENST00000372315.1_Missense_Mutation_p.G86S	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	109					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAACAATGAGGGTGGAAAAAA	0.572000													22	52					0	0	1	0	0
F2RL2	2151	broad.mit.edu	37	5	75914387	75914387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75914387C>T	ENST00000296641.4	-	2	348	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	IQGAP2_ENST00000396234.3_Intron|F2RL2_ENST00000504899.1_Missense_Mutation_p.E27K|IQGAP2_ENST00000274364.6_Intron|IQGAP2_ENST00000502745.1_Intron|IQGAP2_ENST00000379730.3_Intron	NM_004101.3	NP_004092.1	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	49					platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(3)	32		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		GGGAACTCTTCAAAAGAATTT	0.418000													48	121					0	0	1	0	0
C9orf152	401546	broad.mit.edu	37	9	112963672	112963672	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112963672T>C	ENST00000400613.4	-	2	885	c.276A>G	c.(274-276)gaA>gaG	p.E92E	C9orf152_ENST00000473442.1_Intron	NM_001012993.2	NP_001013011.2	Q5JTZ5	CI152_HUMAN	chromosome 9 open reading frame 152	92										NS(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						AATCTGCCTCTTCCAGGGACA	0.552000													10	49					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20144725	20144725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20144725G>A	ENST00000245957.5	+	11	1134	c.1058G>A	c.(1057-1059)gGa>gAa	p.G353E	C20orf26_ENST00000377306.1_Missense_Mutation_p.G353E|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000451767.2_Missense_Mutation_p.G353E|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	353										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ATCTCCACTGGATATGCACAG	0.532000													17	72					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20344598	20344598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20344598C>T	ENST00000298642.2	+	1	208	c.172C>T	c.(172-174)Cct>Tct	p.P58S		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTACACTCTCCTATGTATTT	0.398000													113	243					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401262	89401262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89401262G>A	ENST00000439576.2	+	12	5820	c.5446G>A	c.(5446-5448)Gtt>Att	p.V1816I	ACAN_ENST00000352105.7_Missense_Mutation_p.V1816I|ACAN_ENST00000559004.1_Missense_Mutation_p.V1816I|ACAN_ENST00000561243.1_Missense_Mutation_p.V1816I	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1816					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCCTGACCTGGTTTCTGGTAC	0.512000													17	46					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8207323	8207323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8207323G>A	ENST00000382521.3	+	3	302	c.232G>A	c.(232-234)Gac>Aac	p.D78N	SH3TC1_ENST00000539824.1_Intron|SH3TC1_ENST00000245105.3_Intron			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	349							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						TTTTTCCAGGGACGCGTCAGT	0.557000													12	42					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204924014	204924014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204924014C>T	ENST00000367172.4	+	7	798	c.470C>T	c.(469-471)cCt>cTt	p.P157L	NFASC_ENST00000513543.1_Missense_Mutation_p.P151L|NFASC_ENST00000338586.6_Missense_Mutation_p.P157L|NFASC_ENST00000367169.4_Missense_Mutation_p.P157L|NFASC_ENST00000360049.4_Missense_Mutation_p.P151L|NFASC_ENST00000367171.4_Missense_Mutation_p.P157L|NFASC_ENST00000401399.1_Missense_Mutation_p.P157L|NFASC_ENST00000539706.1_Missense_Mutation_p.P151L|NFASC_ENST00000403080.1_Missense_Mutation_p.P157L|NFASC_ENST00000367170.4_Missense_Mutation_p.P157L|NFASC_ENST00000339876.6_Missense_Mutation_p.P157L|NFASC_ENST00000404907.1_Missense_Mutation_p.P151L|NFASC_ENST00000404076.1_Missense_Mutation_p.P151L|NFASC_ENST00000338515.6_Missense_Mutation_p.P157L			O94856	NFASC_HUMAN	neurofascin	157	Ig-like C2-type 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GAGGGCGCTCCTTTGACGCTC	0.552000													81	203					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96134679	96134679	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96134679C>T	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		CTGTGCACATCCTACGTTACT	0.478000			T	TRA@	T-ALL								14	67					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262636	140262636	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140262636G>A	ENST00000289272.2	+	1	783	c.783G>A	c.(781-783)gtG>gtA	p.V261V	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.V261V|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACATTAGTGATCAAGCTAA	0.423000													36	114					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56742738	56742738	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56742738G>A	ENST00000314128.4	-	17	1569	c.1546C>T	c.(1546-1548)Cag>Tag	p.Q516*	STAT2_ENST00000557235.1_Nonsense_Mutation_p.Q512*|STAT2_ENST00000556539.1_5'UTR			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	516					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						ATGCTCAGCTGGTCTGAGTTG	0.552000													16	67					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24811049	24811049	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24811049C>T	ENST00000221169.5	-	0	2024							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		tcctcctcctcGGCTTCTCCT	0.532000													6	17					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197024862	197024862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197024862G>A	ENST00000367412.1	-	8	1380	c.1337C>T	c.(1336-1338)tCc>tTc	p.S446F		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	446	Sushi 7.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						AACAGGTGGGGATGACCATTT	0.368000													39	73					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71740108	71740108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71740108C>T	ENST00000318442.5	-	5	2200	c.1710G>A	c.(1708-1710)agG>agA	p.R570R		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CGATTCTCCCCCTTCCCAGAC	0.597000													30	49					0	0	1	0	0
TBL2	26608	broad.mit.edu	37	7	72985229	72985229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72985229G>A	ENST00000305632.5	-	7	1193	c.952C>T	c.(952-954)Ccc>Tcc	p.P318S	TBL2_ENST00000459913.1_5'UTR|TBL2_ENST00000432538.1_Missense_Mutation_p.P282S	NM_012453.2	NP_036585.1	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	318										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	19		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGCAAGTAGGGGTCCTGCTTC	0.587000													32	98					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38592977	38592977	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38592977C>T	ENST00000413689.1	-	28	5079	c.4886G>A	c.(4885-4887)cGa>cAa	p.R1629Q	SCN5A_ENST00000423572.2_Missense_Mutation_p.R1628Q|SCN5A_ENST00000425664.1_Missense_Mutation_p.R1611Q|SCN5A_ENST00000333535.4_Missense_Mutation_p.R1629Q|SCN5A_ENST00000451551.2_Missense_Mutation_p.R1575Q|SCN5A_ENST00000455624.2_Missense_Mutation_p.R1596Q|SCN5A_ENST00000449557.2_Missense_Mutation_p.R1575Q|SCN5A_ENST00000450102.2_Missense_Mutation_p.R1575Q|SCN5A_ENST00000443581.1_Missense_Mutation_p.R1628Q|SCN5A_ENST00000414099.2_Missense_Mutation_p.R1611Q	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1629					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCGGCCTATTCGGGCCAGGCG	0.592000													42	94					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20585969	20585969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20585969G>A	ENST00000202677.6	-	15	2030	c.1888C>T	c.(1888-1890)Ctc>Ttc	p.L630F	RALGAPA2_ENST00000495793.1_5'UTR	NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	630					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						CATTCCGTGAGGGAGGACAGC	0.483000													12	42					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20649564	20649564	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20649564C>T	ENST00000428453.1	-	0	2634																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TAATTTCCTTCTTTCCCCATC	0.587000													56	141					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96053623	96053623	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:96053623G>A	ENST00000358812.4	+	5	865		c.e5-1		MANEA_ENST00000474553.1_Splice_Site	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha						post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		TTATTTTCTAGATATGGAAAT	0.348000													16	57					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141525	133141525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133141525G>A	ENST00000388996.4	-	15	3023	c.2603C>T	c.(2602-2604)tCc>tTc	p.S868F	KCNQ3_ENST00000519445.1_Missense_Mutation_p.S856F|KCNQ3_ENST00000521134.1_Missense_Mutation_p.S748F	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	868					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GGGCTTATTGGAAGGGGTCCA	0.532000													6	67					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46202900	46202900	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46202900C>T	ENST00000252934.5	+	10	1500	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L	ATXN10_ENST00000402380.3_Missense_Mutation_p.P63L|ATXN10_ENST00000381061.4_Missense_Mutation_p.P348L	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	412					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		GACAGTAACCCCTGTATCCTT	0.453000													31	86					0	0	1	0	0
SPO11	23626	broad.mit.edu	37	20	55908293	55908293	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:55908293A>C	ENST00000371263.3	+	3	404	c.295A>C	c.(295-297)Aag>Cag	p.K99Q	SPO11_ENST00000345868.4_Missense_Mutation_p.K61Q|SPO11_ENST00000371260.4_Missense_Mutation_p.K61Q	NM_012444.2	NP_036576.1	Q9Y5K1	SPO11_HUMAN	SPO11 meiotic protein covalently bound to DSB	99					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			autonomic_ganglia(1)|breast(3)|large_intestine(4)|lung(8)|skin(2)	18	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			CACCACCAGAAAGATCAAAAG	0.308000								Editing and processing nucleases					8	68					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102480727	102480727	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102480727C>T	ENST00000260228.2	-	4	570	c.558G>A	c.(556-558)cgG>cgA	p.R186R	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	186					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CTAGAGTCCCCCGAGGCCCAT	0.493000													17	45					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63885483	63885483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63885483G>A	ENST00000246841.3	+	2	2787	c.1744G>A	c.(1744-1746)Gag>Aag	p.E582K	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	554					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CCAGGCTGGCGAGCTGCTGAC	0.627000													4	52					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212799896	212799896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:212799896G>A	ENST00000294829.3	+	1	2108	c.1677G>A	c.(1675-1677)agG>agA	p.R559R	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	559										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		TGGCGGAGAGGAGCACCAACG	0.552000													38	101					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63141520	63141520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63141520C>T	ENST00000310969.4	+	3	929	c.661C>T	c.(661-663)Ctt>Ttt	p.L221F	SLC22A9_ENST00000279178.3_Silent_p.I272I			Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	0					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						ACTTTGTGATCTTTCTGACCT	0.428000													9	30					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38539158	38539158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38539158C>T	ENST00000287675.5	+	2	298	c.202C>T	c.(202-204)Cct>Tct	p.P68S	EXOG_ENST00000422077.2_Intron|EXOG_ENST00000358249.2_5'UTR	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	68						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						ATTTGGATTCCCTTTAACTGG	0.393000													31	61					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303861	151303861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151303861C>T	ENST00000370323.4	-	4	548	c.232G>A	c.(232-234)Gat>Aat	p.D78N	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Missense_Mutation_p.D78N	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	78										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GGTGTCTCATCATCAGCAGAA	0.542000													70	57					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8601239	8601239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8601239C>T	ENST00000338257.8	-	19	2207	c.1940G>A	c.(1939-1941)gGg>gAg	p.G647E		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	647	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GCGTTCGTCCCCACGCCACCG	0.652000													7	86					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6096537	6096537	+	Silent	SNP	C	C	T	rs141850118	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6096537C>T	ENST00000217289.4	-	3	1094	c.306G>A	c.(304-306)ccG>ccA	p.P102P	FERMT1_ENST00000536936.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	102	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TCTTCAAATTCGGCAGACGAA	0.498000													40	90					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039366	11039366	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039366G>A	ENST00000470054.1	-	0	837									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTCACTTCAGAAGACATTTT	0.353000													15	368					0	0	1	0	0
DPPA4	55211	broad.mit.edu	37	3	109049587	109049587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:109049587C>T	ENST00000335658.6	-	5	517	c.463G>A	c.(463-465)Gaa>Aaa	p.E155K	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	155						nucleus	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						AGGGACGTTTCCCCCTTTTCC	0.458000													31	97					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230894	21230894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21230894G>A	ENST00000233242.1	-	26	8973	c.8846C>T	c.(8845-8847)aCc>aTc	p.T2949I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2949					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCCTTCTATGGTGAAACTAAT	0.448000													54	177					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5757925	5757925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5757925G>A	ENST00000381624.3	+	14	1411	c.1350G>A	c.(1348-1350)ggG>ggA	p.G450G	CATSPERD_ENST00000309164.7_3'UTR|CATSPERD_ENST00000381614.2_Silent_p.G108G	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	450						integral to membrane											CATCAGATGGGAACACCAAGT	0.567000													18	37					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142586780	142586780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:142586780C>T	ENST00000378004.3	+	21	2361	c.2006C>T	c.(2005-2007)cCa>cTa	p.P669L	ARHGAP26_ENST00000274498.4_Missense_Mutation_p.P669L|ARHGAP26_ENST00000486650.1_Intron	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	669	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATCCAAGCCCAACTTCACCC	0.577000													31	116					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26739344	26739344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26739344C>T	ENST00000272371.2	-	5	577	c.451G>A	c.(451-453)Gga>Aga	p.G151R	OTOF_ENST00000403946.3_Missense_Mutation_p.G151R	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	151					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGCAGTCCATCCGTCTCT	0.632000													29	123					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23066136	23066136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23066136C>T	ENST00000246006.4	-	1	841	c.694G>A	c.(694-696)Gag>Aag	p.E232K		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	232					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CTCTGAGTCTCGTCCTTGTCA	0.597000													47	129					0	0	1	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6882289	6882289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6882289C>T	ENST00000419673.2	+	10	1184	c.967C>T	c.(967-969)Cta>Tta	p.L323L	ARHGAP28_ENST00000262227.3_Silent_p.L430L|ARHGAP28_ENST00000532996.1_Silent_p.L305L|ARHGAP28_ENST00000314319.3_Silent_p.L323L|ARHGAP28_ENST00000383472.4_Silent_p.L482L|ARHGAP28_ENST00000418986.1_Silent_p.L323L|ARHGAP28_ENST00000400091.2_Silent_p.L482L|ARHGAP28_ENST00000531294.1_Silent_p.L318L	NM_001010000.2	NP_001010000.1	B4DXL2	B4DXL2_HUMAN	Rho GTPase activating protein 28	305					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				CTTCATCAGTCTAATGGAAAG	0.403000													19	57					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52818464	52818464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52818464G>A	ENST00000273283.2	+	11	1402	c.1378G>A	c.(1378-1380)Gag>Aag	p.E460K	ITIH1_ENST00000540715.1_Missense_Mutation_p.E318K|ITIH1_ENST00000542827.1_Missense_Mutation_p.E460K|ITIH1_ENST00000537050.1_Missense_Mutation_p.E172K	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	460	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GAGAATCTACGAGGACCATGA	0.582000													24	55					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126079218	126079218	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:126079218G>A	ENST00000339582.2	-	11	3490	c.2682C>T	c.(2680-2682)tcC>tcT	p.S894S	GRM8_ENST00000444921.2_Silent_p.S894S|GRM8_ENST00000358373.3_3'UTR			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	894					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TCTTGGTAGAGGAAGCTGTTA	0.289000										HNSCC(24;0.065)			55	122					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8185497	8185497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8185497G>A	ENST00000520004.1	-	5	3059	c.2795C>T	c.(2794-2796)aCc>aTc	p.T932I	SGK223_ENST00000330777.4_Missense_Mutation_p.T932I			Q86YV5	SG223_HUMAN		932							ATP binding|non-membrane spanning protein tyrosine kinase activity										CTGAAGCTGGGTGCTCCCGGT	0.657000													11	47					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37670821	37670821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37670821G>A	ENST00000264741.5	+	16	2089	c.1833G>A	c.(1831-1833)aaG>aaA	p.K611K	ITGA9_ENST00000422441.1_Silent_p.K611K	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	611					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TTGCCCAAAAGAATCAGGTCA	0.532000													8	24					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74361203	74361203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:74361203G>A	ENST00000377044.4	-	3	925	c.386C>T	c.(385-387)tCt>tTt	p.S129F	TMEM2_ENST00000377066.5_Missense_Mutation_p.S129F	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	129	G8.					integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TTGCTTTGCAGAATCTTGTCC	0.433000													10	78					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55615307	55615307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55615307C>T	ENST00000326258.1	+	1	499	c.499C>T	c.(499-501)Cct>Tct	p.P167S		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						GATGGCCCTTCCTTTCTGTGG	0.478000													34	96					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6594233	6594233	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6594233C>T	ENST00000433363.2	-	10	1535	c.1302G>A	c.(1300-1302)ggG>ggA	p.G434G	SLC13A5_ENST00000293800.6_Silent_p.G417G|SLC13A5_ENST00000381074.4_Silent_p.G391G|SLC13A5_ENST00000573648.1_Silent_p.G434G	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	434						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						CCATCTGCTTCCCCATCCACA	0.627000													41	50					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887096	9887096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:9887096G>A	ENST00000306084.6	+	2	819	c.620G>A	c.(619-621)gGt>gAt	p.G207D	TXNDC2_ENST00000357775.4_Missense_Mutation_p.G140D|TXNDC2_ENST00000536353.2_Intron	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	207	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						CCCAAAGAGGGTGACATCCCC	0.567000													38	187					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18753478	18753478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18753478C>T	ENST00000380548.4	+	16	2528	c.2189C>T	c.(2188-2190)cCa>cTa	p.P730L		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	730						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		AATTGCCCCCCAGCCTGGTAC	0.512000													6	15					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167056366	167056366	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167056366G>A	ENST00000375387.4	-	27	5126	c.4786C>T	c.(4786-4788)Cta>Tta	p.L1596L	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Silent_p.L1595L|SCN9A_ENST00000409672.1_Silent_p.L1584L|SCN9A_ENST00000303354.6_Silent_p.L1596L			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1595						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AAATCAGCTAGAAACATACCT	0.378000													34	87					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143679	55143679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55143679C>T	ENST00000396331.1	+	6	1009	c.652C>T	c.(652-654)Ctg>Ttg	p.L218L	LILRB1_ENST00000448689.1_Silent_p.L218L|LILRB1_ENST00000434867.2_Silent_p.L218L|LILRB1_ENST00000396332.4_Silent_p.L218L|LILRB1_ENST00000427581.2_Silent_p.L254L|LILRB1_ENST00000324602.7_Silent_p.L218L|LILRB1_ENST00000418536.2_Silent_p.L218L|LILRB1_ENST00000396317.1_Silent_p.L218L|LILRB1_ENST00000396321.2_Silent_p.L218L|LILRB1_ENST00000396315.1_Silent_p.L218L|LILRB1_ENST00000396327.3_Silent_p.L218L	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	218	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCTGGAGCTCCTGGTCCTAGG	0.592000										HNSCC(37;0.09)			48	147					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60753853	60753853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60753853G>A	ENST00000303375.5	+	11	2197	c.1795G>A	c.(1795-1797)Gat>Aat	p.D599N		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	599	C-type lectin 3.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GCTCAGTGGGGATGAAGTCAT	0.617000													43	97					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174768	51174768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51174768C>T	ENST00000440970.1	-	2	1505	c.1074G>A	c.(1072-1074)gcG>gcA	p.A358A	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.A455A	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	455					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CAAAGACCTTCGCGCAGAACC	0.512000													44	82					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602760	96602760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96602760C>T	ENST00000371321.3	+	7	1210	c.1128C>T	c.(1126-1128)ttC>ttT	p.F376F	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	376					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	ACGTTAAATTCAGAAACTACC	0.473000													37	138					0	0	1	0	0
IGKV3D-11	28876	broad.mit.edu	37	2	90212209	90212209	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90212209G>A	ENST00000390277.2	+	0	398																											CCTAGAGCCTGAAGATTTTGC	0.502000													39	72					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111748180	111748180	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111748180G>C	ENST00000261726.6	+	15	1748	c.1594G>C	c.(1594-1596)Ggt>Cgt	p.G532R		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	532	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GCCACTGGGCGGTCCTGAGCC	0.741000													3	20					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161019326	161019326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161019326C>T	ENST00000368013.3	-	11	1894	c.1574G>A	c.(1573-1575)gGg>gAg	p.G525E	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.G525E|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.G348E	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	525					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ATCCTCTGCCCCCACCCACTC	0.647000													32	110					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143049018	143049018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143049018G>A	ENST00000343257.2	+	23	3014	c.2927G>A	c.(2926-2928)cGa>cAa	p.R976Q		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	976					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CCCAGCCTGCGATCCACAGAC	0.617000													26	94					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107491536	107491536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:107491536C>T	ENST00000415149.2	+	11	1295	c.968C>T	c.(967-969)tCc>tTc	p.S323F	BBX_ENST00000325805.8_Missense_Mutation_p.S323F|BBX_ENST00000416476.2_Intron|BBX_ENST00000402543.1_Missense_Mutation_p.S323F|BBX_ENST00000406780.1_Missense_Mutation_p.S323F	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	323					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GCAAAAGAATCCGATGGTGGA	0.348000													14	78					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58475249	58475249	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58475249G>A	ENST00000357552.3	-	18	1573	c.1348C>T	c.(1348-1350)Cct>Tct	p.P450S	SYCP2_ENST00000371001.2_Missense_Mutation_p.P450S			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	450					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TATTTTGAAGGTTTAGCAAAT	0.358000													20	62					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96792160	96792160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96792160G>A	ENST00000359933.4	-	15	3156	c.2263C>T	c.(2263-2265)Cgc>Tgc	p.R755C		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	755										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		ATTGGGAAGCGAACAGAAAGG	0.413000													11	103					0	0	1	0	0
PXMP2	5827	broad.mit.edu	37	12	133272542	133272542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:133272542C>T	ENST00000317479.3	+	3	374	c.309C>T	c.(307-309)ccC>ccT	p.P103P	PXMP2_ENST00000428960.2_Silent_p.P10P|PXMP2_ENST00000543589.1_Intron|RP13-672B3.2_ENST00000537262.1_Intron|PXMP2_ENST00000539093.1_Intron|PXMP2_ENST00000545677.1_Intron	NM_018663.1	NP_061133.1	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	103						integral to membrane|peroxisomal membrane	protein binding			large_intestine(1)|liver(2)|lung(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		CTGAGGTCCCCCTGGCAGGGC	0.572000													6	51					0	0	1	0	0
TDGF1P3	6998	broad.mit.edu	37	X	109764975	109764975	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:109764975C>T	ENST00000602699.1	+	0	1436					NR_002718.2																						ATGCAAATTTCATGACCCGTA	0.343000													15	22					0	0	1	0	0
POTEB	100996331	broad.mit.edu	37	15	22062320	22062320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22062320G>A	ENST00000439682.1	-	9	1345	c.1294C>T	c.(1294-1296)Cac>Tac	p.H432Y		NM_001277304.1	NP_001264233.1	Q6S5H4	POTEB_HUMAN	POTE ankyrin domain family, member B	469										endometrium(2)|kidney(8)|lung(4)	14						GCTCACCTGTGATACTCTTCA	0.373000													36	32					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3428168	3428168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3428168G>A	ENST00000356575.4	-	9	1286	c.1060C>T	c.(1060-1062)Ctg>Ttg	p.L354L	MEGF6_ENST00000294599.4_Silent_p.L249L	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	354	EGF-like 6.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CATGTGCACAGGGGCCCAGCA	0.642000													22	63					0	0	1	0	0
ENO1	2023	broad.mit.edu	37	1	8924024	8924024	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8924024G>A	ENST00000234590.4	-	9	1112	c.993C>T	c.(991-993)gcC>gcT	p.A331A		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	331					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		TCTCGTTCACGGCCTTGGCGA	0.562000													79	212					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	132826487	132826487	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:132826487A>G	ENST00000370818.3	-	5	1647	c.1202T>C	c.(1201-1203)tTc>tCc	p.F401S	GPC3_ENST00000543339.1_Missense_Mutation_p.F347S|GPC3_ENST00000394299.2_Missense_Mutation_p.F424S	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	401						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					AGCACTATAGAAGCTGATGAA	0.413000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				41	31					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38793958	38793958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38793958G>A	ENST00000359357.3	+	27	3477	c.3223G>A	c.(3223-3225)Gag>Aag	p.E1075K	DNAH8_ENST00000441566.1_Missense_Mutation_p.E1075K|DNAH8_ENST00000449981.2_Missense_Mutation_p.E1292K					dynein, axonemal, heavy chain 8									p.E1075Q(1)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTTATCCATCGAGGCCAAGGC	0.333000													11	34					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532026	84532026	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84532026C>T	ENST00000527857.1	+	0	2048					NR_026851.1																						GGTCCATGTTCCCATCTCCAT	0.478000													9	57					0	0	1	0	0
APOA5	116519	broad.mit.edu	37	11	116661443	116661443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:116661443C>T	ENST00000542499.1	-	4	574	c.502G>A	c.(502-504)Gag>Aag	p.E168K	APOA5_ENST00000227665.4_Missense_Mutation_p.E168K	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	168					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		GCCCAAGCCTCGTCCACGCCC	0.667000													20	53					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37770944	37770944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37770944C>T	ENST00000402918.1	-	3	1416	c.631G>A	c.(631-633)Gac>Aac	p.D211N	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Missense_Mutation_p.D211N	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	211	LRRCT.					cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					TGCAGGCGGTCGTAGTTCTTG	0.632000													11	21					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89662818	89662818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89662818C>T	ENST00000355754.6	-	2	307	c.210G>A	c.(208-210)atG>atA	p.M70I		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	70						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		CAAGACGATTCATGAGATAGG	0.488000													19	56					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36778713	36778713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36778713G>A	ENST00000416516.2	-	2	1928	c.1438C>T	c.(1438-1440)Ccg>Tcg	p.P480S		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	480	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						AGGTTTTCCGGCTTGAGGTCC	0.453000													12	41					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27789904	27789904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27789904C>T	ENST00000261588.4	+	28	4830	c.4811C>T	c.(4810-4812)cCc>cTc	p.P1604L		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1604										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GCCTTACGTCCCAAAACCTGC	0.597000													25	102					0	0	1	0	0
PRL	5617	broad.mit.edu	37	6	22294766	22294766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:22294766C>T	ENST00000306482.1	-	2	594	c.76G>A	c.(76-78)Gtg>Atg	p.V26M	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	26					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					AAGGGGGCCACGCTCTGGCAC	0.592000													4	26					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28478684	28478684	+	Missense_Mutation	SNP	G	G	A	rs143710331		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28478684G>A	ENST00000261609.7	-	29	4483	c.4375C>T	c.(4375-4377)Cat>Tat	p.H1459Y		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1459					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCACCTGCATGAACTAAAGAT	0.418000													35	103					0	0	1	0	0
TPST2	8459	broad.mit.edu	37	22	26937530	26937530	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26937530G>A	ENST00000338754.4	-	3	337	c.67C>T	c.(67-69)Cag>Tag	p.Q23*	TPST2_ENST00000403880.1_Nonsense_Mutation_p.Q23*|TPST2_ENST00000398110.2_Nonsense_Mutation_p.Q23*	NM_003595.3	NP_003586.3	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	23					peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)|large_intestine(1)|lung(5)	7						TGTCCCAGCTGAACCGCCAGC	0.741000													3	18					0	0	1	0	0
NPTX1	4884	broad.mit.edu	37	17	78445594	78445594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78445594C>T	ENST00000306773.4	-	4	1172	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K		NM_002522.3	NP_002513.2	Q15818	NPTX1_HUMAN	neuronal pentraxin I	339	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)	11	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GCCAAGTTCTCGCCACTGCCA	0.632000													23	49					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99582506	99582506	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:99582506G>A	ENST00000376460.1	-	3	329	c.249C>T	c.(247-249)gcC>gcT	p.A83A	DOCK9_ENST00000339416.2_Silent_p.A84A|DOCK9_ENST00000448493.2_Silent_p.A95A|DOCK9_ENST00000442173.1_Silent_p.A83A	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	84	Interaction with activated CDC42 (By similarity).				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTCTCAGGATGGCCGTCTGGA	0.552000													6	11					0	0	1	0	0
IL15RA	3601	broad.mit.edu	37	10	6008179	6008179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6008179C>T	ENST00000525219.2	-	2	398	c.104G>A	c.(103-105)aGc>aAc	p.S35N	IL15RA_ENST00000379971.1_Intron|IL15RA_ENST00000530685.1_Missense_Mutation_p.S71N|IL15RA_ENST00000397250.2_Intron|IL15RA_ENST00000397248.2_Missense_Mutation_p.S35N|IL15RA_ENST00000379977.3_Missense_Mutation_p.S71N|IL15RA_ENST00000534292.1_5'UTR|IL15RA_ENST00000397251.3_Intron|IL15RA_ENST00000397255.3_Missense_Mutation_p.S71N|IL15RA_ENST00000528354.1_Missense_Mutation_p.S71N	NM_001243539.1	NP_001230468.1	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha	71	Sushi.				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5						CTCCGTCAGGCTGGACGTGCC	0.552000													17	35					0	0	1	0	0
MAP3K15	389840	broad.mit.edu	37	X	19410551	19410551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:19410551C>T	ENST00000338883.4	-	17	2234	c.2235G>A	c.(2233-2235)atG>atA	p.M745I	MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Missense_Mutation_p.M577I|MAP3K15_ENST00000359173.3_Missense_Mutation_p.M180I	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	745	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					TCGGTTCCTTCATCGGCCCCC	0.433000													64	34					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18075548	18075548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18075548C>T	ENST00000205890.5	+	64	10632	c.10294C>T	c.(10294-10296)Cct>Tct	p.P3432S	MYO15A_ENST00000451725.2_Silent_p.P225P|MYO15A_ENST00000418233.3_Missense_Mutation_p.P696S	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	3432	FERM.|Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TGTGCCAGCCCCTTGCATCCT	0.587000													27	37					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582564	136582564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136582564G>A	ENST00000531224.1	-	12	2848	c.2596C>T	c.(2596-2598)Cgt>Tgt	p.R866C	BCLAF1_ENST00000527536.1_Missense_Mutation_p.R817C|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R864C|BCLAF1_ENST00000031135.9_Missense_Mutation_p.R84C|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000392348.2_Missense_Mutation_p.R815C|BCLAF1_ENST00000530767.1_Missense_Mutation_p.R693C|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R815C	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	866					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAAGTACCACGACCTCTTCCT	0.408000													55	310					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36169514	36169514	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:36169514C>T	ENST00000335119.2	+	1	126	c.15C>T	c.(13-15)ttC>ttT	p.F5F		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	5					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			AATTGGAATTCACGGAGAAAA	0.493000													12	40					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74565190	74565190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74565190G>A	ENST00000321288.5	+	9	1326	c.1326G>A	c.(1324-1326)atG>atA	p.M442I	CCDC33_ENST00000398814.3_Missense_Mutation_p.M239I			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	442							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CGTCCATGATGAACTTTGACG	0.602000													24	103					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93148220	93148220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93148220G>A	ENST00000298050.3	+	13	1678	c.1578G>A	c.(1576-1578)tcG>tcA	p.S526S	CCDC67_ENST00000525646.1_Silent_p.S268S	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	526										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TGCCACCTTCGACATTTCAAG	0.413000													23	84					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	169995191	169995191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169995191C>T	ENST00000263816.3	-	75	13699	c.13414G>A	c.(13414-13416)Gaa>Aaa	p.E4472K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4472					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTCCCATTTTCAGAGGGCTTG	0.418000													12	68					0	0	1	0	0
FBXL12	54850	broad.mit.edu	37	19	9922101	9922101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9922101G>A	ENST00000247977.4	-	3	693	c.452C>T	c.(451-453)cCc>cTc	p.P151L	FBXL12_ENST00000589626.1_3'UTR|FBXL12_ENST00000585379.1_Missense_Mutation_p.P98L|FBXL12_ENST00000592067.1_3'UTR|FBXL12_ENST00000586651.1_3'UTR|FBXL12_ENST00000591009.1_Missense_Mutation_p.P98L|FBXL12_ENST00000588922.1_3'UTR	NM_017703.1	NP_060173.1	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	151							protein binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(2)	10						TTCAAGCAGGGGCAGCACGGT	0.677000													24	66					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57860961	57860961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:57860961C>T	ENST00000381227.1	+	6	918	c.505C>T	c.(505-507)Cgt>Tgt	p.R169C	POLR2B_ENST00000314595.5_Missense_Mutation_p.R169C|POLR2B_ENST00000431623.2_Missense_Mutation_p.R94C|POLR2B_ENST00000441246.2_Missense_Mutation_p.R162C			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	169					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					CTTGACAGATCGTGATCTTTG	0.338000													41	78					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841197	13841197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13841197C>T	ENST00000265104.4	-	34	5631	c.5527G>A	c.(5527-5529)Gaa>Aaa	p.E1843K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1843	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGGGCTTCTTCTGAATCCCGT	0.348000									Kartagener syndrome				31	57					0	0	1	0	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293708	71293708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71293708G>A	ENST00000398530.1	-	1	213	c.176C>T	c.(175-177)tCc>tTc	p.S59F	KRTAP5-11_ENST00000526239.1_Intron|AP000867.1_ENST00000343767.3_Intron	NM_001005405.2	NP_001005405.1	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	59	6 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						GCCCCCACAGGAGCCACAGCT	0.632000													18	261					0	0	1	0	0
SPRY1	10252	broad.mit.edu	37	4	124322981	124322981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:124322981G>A	ENST00000394339.2	+	2	575	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	SPRY1_ENST00000339241.1_Missense_Mutation_p.E79K	NM_001258039.1|NM_005841.2	NP_001244968.1|NP_005832.1	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	79					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				NS(1)|large_intestine(4)|lung(2)|ovary(1)|skin(3)	11						AAGGACTCATGAAATCATACC	0.478000													37	96					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13361447	13361447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13361447G>A	ENST00000254508.5	-	37	5281	c.5199C>T	c.(5197-5199)ttC>ttT	p.F1733F		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1733					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TCTCCTTTGCGAATGCCAGCA	0.627000													17	58					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39008179	39008179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39008179C>T	ENST00000355481.4	+	66	9997	c.9866C>T	c.(9865-9867)cCc>cTc	p.P3289L	RYR1_ENST00000359596.3_Missense_Mutation_p.P3289L|RYR1_ENST00000360985.3_Missense_Mutation_p.P3289L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3289					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAGCGCGGGCCCGAGGCACCC	0.667000													20	31					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84256226	84256226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84256226G>A	ENST00000308251.4	-	3	1225	c.1157C>T	c.(1156-1158)tCc>tTc	p.S386F		NM_172347.2	NP_758857.1	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	386						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GACCAAAGGGGAGAAGAGGGT	0.642000													3	28					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104516006	104516006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104516006G>A	ENST00000409874.4	+	35	4084	c.4036G>A	c.(4036-4038)Gag>Aag	p.E1346K	TDRD9_ENST00000339063.5_Missense_Mutation_p.E1155K	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	1346					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				AAAGCCCTACGAGTGGAATCA	0.478000													5	13					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82834003	82834003	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82834003G>A	ENST00000265077.3	+	8	5746	c.5181G>A	c.(5179-5181)gaG>gaA	p.E1727E	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.E740E|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1727	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAAGGAAGGAGGAGGAGGGAA	0.403000													37	93					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4245738	4245738	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4245738C>T	ENST00000399609.3	-	5	438	c.426G>A	c.(424-426)aaG>aaA	p.K142K	SRL_ENST00000537996.1_Silent_p.K100K	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	601	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						TGGTTTTCAGCTTAGGCCCAT	0.542000													5	29					0	0	1	0	0
FAM122C	159091	broad.mit.edu	37	X	133981471	133981471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:133981471C>T	ENST00000445123.1	+	8	1445	c.149C>T	c.(148-150)tCc>tTc	p.S50F	FAM122C_ENST00000370784.4_Intron|FAM122C_ENST00000370785.3_Missense_Mutation_p.S135F			Q6P4D5	F222C_HUMAN	family with sequence similarity 122C	0										endometrium(2)|kidney(1)|lung(2)	5	Acute lymphoblastic leukemia(192;0.000127)					ACTCCAGTATCCTCAATGGCT	0.368000													33	32					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39817345	39817345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39817345C>T	ENST00000442448.1	-	4	510	c.239G>A	c.(238-240)aGc>aAc	p.S80N	ERG_ENST00000453032.2_Intron|ERG_ENST00000398907.1_Missense_Mutation_p.S73N|ERG_ENST00000398911.1_Missense_Mutation_p.S80N|ERG_ENST00000398919.2_Missense_Mutation_p.S80N|ERG_ENST00000429727.2_Missense_Mutation_p.S73N|ERG_ENST00000398905.1_Missense_Mutation_p.S73N|ERG_ENST00000398910.1_Missense_Mutation_p.S80N|ERG_ENST00000417133.2_Missense_Mutation_p.S80N|ERG_ENST00000398897.1_Intron|ERG_ENST00000288319.7_Missense_Mutation_p.S73N	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	80					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				ATTCACCTGGCTAGGGTTACA	0.527000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								13	35					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6245348	6245348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6245348G>A	ENST00000265978.4	-	3	627	c.269C>T	c.(268-270)cCc>cTc	p.P90L	FAM160A2_ENST00000524416.1_Missense_Mutation_p.P90L|FAM160A2_ENST00000449352.2_Missense_Mutation_p.P90L	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	90					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGGGCCTGTGGGGGCCGAGGG	0.627000													13	31					0	0	1	0	0
KMO	8564	broad.mit.edu	37	1	241725561	241725561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:241725561C>T	ENST00000366559.4	+	7	855	c.544C>T	c.(544-546)Cgc>Tgc	p.R182C	KMO_ENST00000366558.3_Missense_Mutation_p.R182C|KMO_ENST00000484628.1_3'UTR|KMO_ENST00000366557.4_Missense_Mutation_p.R182C	NM_003679.4	NP_003670.2	O15229	KMO_HUMAN	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	182					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GAAGAAACCTCGCTTTGATTA	0.438000													30	120					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207787802	207787802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207787802C>T	ENST00000367049.4	+	40	6629	c.6629C>T	c.(6628-6630)gCc>gTc	p.A2210V	CR1_ENST00000400960.2_Missense_Mutation_p.A1760V|CR1_ENST00000367052.1_Missense_Mutation_p.A1760V|CR1_ENST00000367053.1_Missense_Mutation_p.A1760V|CR1_ENST00000367051.1_Missense_Mutation_p.A1760V	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1760					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GGAATGAAAGCCCTTTGGAAT	0.413000													19	88					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211093356	211093356	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:211093356C>T	ENST00000367007.4	-	7	1176	c.1007G>A	c.(1006-1008)cGa>cAa	p.R336Q	KCNH1_ENST00000271751.4_Missense_Mutation_p.R363Q	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	363					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity	p.R363Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ACGGGCCACTCGCCCAAGACG	0.562000													21	111					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41159280	41159280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41159280C>T	ENST00000263413.3	-	12	2024	c.1760G>A	c.(1759-1761)cGa>cAa	p.R587Q	C6_ENST00000337836.5_Missense_Mutation_p.R587Q	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	587	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ATTGCATTCTCGGGTTCTCGA	0.493000													32	95					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81648681	81648681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81648681G>A	ENST00000548058.1	+	16	2951	c.2041G>A	c.(2041-2043)Gaa>Aaa	p.E681K	ACSS3_ENST00000548324.1_Missense_Mutation_p.E363K|ACSS3_ENST00000261206.3_Missense_Mutation_p.E680K			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	681						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CCACGTAGAAGAAATGCTGAA	0.308000													27	89					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57180319	57180319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:57180319C>T	ENST00000504228.1	+	6	756	c.651C>T	c.(649-651)tcC>tcT	p.S217S	KIAA1211_ENST00000264229.6_Silent_p.S217S|KIAA1211_ENST00000541073.1_Silent_p.S210S			Q6ZU35	K1211_HUMAN	KIAA1211	217	Glu-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CGCTGGATTCCGAGGAAGAGA	0.607000													10	34					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123908902	123908902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123908902C>T	ENST00000330487.5	-	1	815	c.807G>A	c.(805-807)ggG>ggA	p.G269G		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CGGCCACAACCCCATGCAAGG	0.512000													29	64					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50413309	50413309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50413309G>A	ENST00000435965.1	-	20	1949	c.1776C>T	c.(1774-1776)atC>atT	p.I592I	CACNA2D2_ENST00000423994.2_Silent_p.I592I|CACNA2D2_ENST00000266039.3_Silent_p.I592I|CACNA2D2_ENST00000479441.1_Silent_p.I592I|CACNA2D2_ENST00000424201.2_Silent_p.I592I|CACNA2D2_ENST00000360963.3_Silent_p.I523I|CACNA2D2_ENST00000395083.1_Silent_p.I592I|CACNA2D2_ENST00000429770.1_Silent_p.I592I			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	592					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TGCTCCGACGGATCTGGAAGG	0.592000													9	94					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202185	248202185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248202185C>T	ENST00000366479.2	+	1	712	c.616C>T	c.(616-618)Ctt>Ttt	p.L206F	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CACCATCTTTCTTGTGCTTCC	0.478000													28	255					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178562106	178562106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:178562106G>A	ENST00000286063.5	-	15	2616	c.2299C>T	c.(2299-2301)Ctt>Ttt	p.L767F	PDE11A_ENST00000358450.4_Missense_Mutation_p.L517F|PDE11A_ENST00000409504.1_Missense_Mutation_p.L409F|PDE11A_ENST00000449286.2_Missense_Mutation_p.L409F|PDE11A_ENST00000389683.3_Missense_Mutation_p.L323F|PDE11A_ENST00000497003.1_5'UTR	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	767	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGCTTCAAAAGCTGCATAAGG	0.383000									Primary Pigmented Nodular Adrenocortical Disease, Familial				15	90					0	0	1	0	0
OR4F15	390649	broad.mit.edu	37	15	102358832	102358832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:102358832C>T	ENST00000332238.4	+	1	467	c.443C>T	c.(442-444)tCc>tTc	p.S148F		NM_001001674.1	NP_001001674.1	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F, member 15	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(10)	19	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTAGCCACTTCCTCTATCATT	0.403000													82	261					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68643118	68643118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68643118G>A	ENST00000423218.2	-	9	992	c.897C>T	c.(895-897)gtC>gtT	p.V299V	ITGA11_ENST00000315757.7_Silent_p.V299V			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	299	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	AGTAGCCCAGGACCTGCCAGG	0.527000													49	71					0	0	1	0	0
KLHL26	55295	broad.mit.edu	37	19	18775224	18775224	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18775224C>T	ENST00000300976.4	+	2	327	c.237C>T	c.(235-237)gtC>gtT	p.V79V	KLHL26_ENST00000599006.1_Silent_p.V79V|KLHL26_ENST00000595182.1_Silent_p.V79V|KLHL26_ENST00000596843.1_3'UTR	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	79	BTB.									breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						CACACAAGGTCGTCCTGGCTG	0.642000													25	122					0	0	1	0	0
KLK5	25818	broad.mit.edu	37	19	51452325	51452325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51452325C>T	ENST00000336334.3	-	4	734	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	KLK5_ENST00000593428.1_Missense_Mutation_p.E128K|KLK5_ENST00000391809.2_Missense_Mutation_p.E128K	NM_012427.4	NP_036559.1	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5	128	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			NS(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		TGCCCAGATTCATAAACTGGT	0.542000													38	109					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24538596	24538596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24538596G>A	ENST00000342740.5	+	40	4256	c.4102G>A	c.(4102-4104)Gag>Aag	p.E1368K	LRRC16B_ENST00000334420.7_Missense_Mutation_p.E421K	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1368										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		AGGAACCAGTGAGCCAGGAAC	0.627000													29	44					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97484836	97484836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:97484836C>T	ENST00000376705.2	+	2	824	c.800C>T	c.(799-801)tCt>tTt	p.S267F		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	267						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					TGGAAAACCTCTCTTCATATG	0.507000													16	45					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48764779	48764779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48764779G>A	ENST00000316623.5	-	35	4760	c.4305C>T	c.(4303-4305)ttC>ttT	p.F1435F		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1435	EGF-like 24; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CACTGGGCACGAAGCCCATGT	0.522000													58	116					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173351826	173351826	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:173351826A>T	ENST00000375221.2	+	15	2250	c.2047A>T	c.(2047-2049)Acc>Tcc	p.T683S	ITGA6_ENST00000264106.6_Missense_Mutation_p.T683S|ITGA6_ENST00000409532.1_Missense_Mutation_p.T525S|ITGA6_ENST00000409080.1_Missense_Mutation_p.T644S|AC093818.1_ENST00000442417.1_RNA|ITGA6_ENST00000343713.4_Missense_Mutation_p.T639S|ITGA6_ENST00000264107.7_Missense_Mutation_p.T644S			P23229	ITA6_HUMAN	integrin, alpha 6	683					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TAAATTTTGCACCCGAGAAGG	0.358000													11	45					0	0	1	0	0
ASS1	445	broad.mit.edu	37	9	133339513	133339513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133339513C>T	ENST00000372394.1	+	6	860	c.379C>T	c.(379-381)Cgg>Tgg	p.R127W	ASS1_ENST00000372393.3_Missense_Mutation_p.R127W|ASS1_ENST00000352480.5_Missense_Mutation_p.R127W			P00966	ASSY_HUMAN	argininosuccinate synthase 1	127			R -> Q (in CTLN1).|R -> W (in CTLN1; severe clinical course).		arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	17				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	CGATCAGGTCCGGTTTGAGCT	0.602000													10	64					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19634676	19634676	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19634676G>A	ENST00000235835.3	-	3	588	c.567C>T	c.(565-567)ggC>ggT	p.G189G		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	189					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGATCCAGCCATTGCTCT	0.612000													26	71					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6752821	6752821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6752821G>A	ENST00000229243.2	-	6	1054	c.961C>T	c.(961-963)Cac>Tac	p.H321Y	ACRBP_ENST00000542357.1_5'UTR|ACRBP_ENST00000414226.2_Missense_Mutation_p.H288Y	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	321						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						GCCTCTGTGTGGGGCAGCTGC	0.587000													30	87					0	0	1	0	0
GSTM5	2949	broad.mit.edu	37	1	110254965	110254965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110254965C>T	ENST00000369812.5	+	1	102	c.31C>T	c.(31-33)Cgt>Tgt	p.R11C	GSTM5_ENST00000256593.3_Missense_Mutation_p.R11C|GSTM5_ENST00000369813.1_5'UTR			P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	11	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity	p.R11C(1)		NS(1)|central_nervous_system(6)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	21		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	CTGGGACATCCGTGGGGTAAG	0.637000													19	221					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4150369	4150369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4150369G>A	ENST00000404826.2	+	23	3538	c.3399G>A	c.(3397-3399)ctG>ctA	p.L1133L	SDK1_ENST00000389531.3_Silent_p.L1133L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1133	Fibronectin type-III 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCAGATGCTGGAGATCCCAA	0.557000													23	40					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021113	5021113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5021113C>T	ENST00000382545.3	+	2	1676	c.569C>T	c.(568-570)cCc>cTc	p.P190L	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	190					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAGACGCTCCCCGAGCTGAAG	0.572000													23	63					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4229251	4229251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:4229251G>A	ENST00000379453.4	-	1	470	c.354C>T	c.(352-354)atC>atT	p.I118I		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	118					cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	CCACTGAGAGGATGACAAGCA	0.652000													7	32					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152544005	152544005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152544005C>T	ENST00000427231.2	-	27	2767	c.2565G>A	c.(2563-2565)atG>atA	p.M855I	NEB_ENST00000604864.1_Missense_Mutation_p.M855I|NEB_ENST00000603639.1_Missense_Mutation_p.M855I|NEB_ENST00000172853.10_Missense_Mutation_p.M855I|NEB_ENST00000397345.3_Missense_Mutation_p.M855I|NEB_ENST00000409198.1_Missense_Mutation_p.M855I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	855					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGGCTCCAATCATTTTCCCTT	0.458000													19	173					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98084132	98084132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98084132G>A	ENST00000419175.1	+	6	1030	c.860G>A	c.(859-861)cGa>cAa	p.R287Q	DNTT_ENST00000371174.2_Missense_Mutation_p.R287Q	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	287	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AAATTTACACGAATGCAGAAA	0.453000													30	104					0	0	1	0	0
CXCL5	6374	broad.mit.edu	37	4	74863807	74863807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74863807G>A	ENST00000296027.4	-	3	445	c.248C>T	c.(247-249)tCc>tTc	p.S83F		NM_002994.3	NP_002985.1	P42830	CXCL5_HUMAN	chemokine (C-X-C motif) ligand 5	83					cell-cell signaling|chemotaxis|immune response|positive regulation of cell proliferation|signal transduction	extracellular space	chemokine activity			endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(1)	9	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			GTTCTTCAGGGAGGCTCTGAA	0.453000													29	93					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100126602	100126602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100126602C>T	ENST00000524871.1	+	17	2406	c.2116C>T	c.(2116-2118)Ctt>Ttt	p.L706F	CNTN5_ENST00000527185.1_Missense_Mutation_p.L706F|CNTN5_ENST00000528682.1_Missense_Mutation_p.L706F|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Missense_Mutation_p.L706F|CNTN5_ENST00000418526.2_Missense_Mutation_p.L632F	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	706	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTCCTACAACCTTCAAGCTCG	0.502000													28	50					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87235216	87235216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87235216C>T	ENST00000297524.3	-	2	905	c.802G>A	c.(802-804)Gaa>Aaa	p.E268K	SLC7A13_ENST00000419776.2_Missense_Mutation_p.E259K|SLC7A13_ENST00000520624.1_5'UTR	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	268						integral to membrane	amino acid transmembrane transporter activity	p.E268K(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						GAGAGAATTTCCCTGGGTGTC	0.383000													35	102					0	0	1	0	0
NPTX2	4885	broad.mit.edu	37	7	98249169	98249169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98249169G>A	ENST00000265634.3	+	2	806	c.641G>A	c.(640-642)cGa>cAa	p.R214Q		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	214					synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GAGCTGGAGCGAGGTGTGTGC	0.587000													4	29					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34493208	34493208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34493208C>T	ENST00000242317.4	+	9	869	c.698C>T	c.(697-699)gCc>gTc	p.A233V	DNAI1_ENST00000488369.1_3'UTR	NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	233					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		ATCTATGATGCCTATGTAGAG	0.453000									Kartagener syndrome				16	91					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156276982	156276982	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156276982C>T	ENST00000311277.4	-	9	1439	c.1176G>A	c.(1174-1176)tcG>tcA	p.S392S	AC097467.2_ENST00000417474.1_RNA|AC097467.2_ENST00000601977.1_RNA|MAP9_ENST00000515654.1_Silent_p.S368S|AC097467.2_ENST00000593387.1_RNA|AC097467.2_ENST00000598252.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	392					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		AGGTAGTTGTCGATGGAGTTC	0.348000													8	50					0	0	1	0	0
MIR527	574497	broad.mit.edu	37	19	54257294	54257294	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54257294G>A	ENST00000385244.1	+	0	23					NR_030219.1																						ACTGCAAAGGGAAGCCCTTTC	0.418000													25	189					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134896036	134896036	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134896036C>T	ENST00000607359.1	+	6	1122	c.1122C>T	c.(1120-1122)ttC>ttT	p.F374F				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CTCCTGCCTTCTTTCAATACC	0.587000													7	15					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92616397	92616397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92616397G>A	ENST00000298047.6	+	23	12792	c.12775G>A	c.(12775-12777)Gag>Aag	p.E4259K	FAT3_ENST00000525166.1_Missense_Mutation_p.E4109K|FAT3_ENST00000533797.1_Missense_Mutation_p.E594K|FAT3_ENST00000409404.2_Missense_Mutation_p.E4259K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4259					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.E4259K(2)|p.E834K(1)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTGGGAGGCGAGCACCAGGA	0.682000										TCGA Ovarian(4;0.039)			50	161					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20337703	20337703	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20337703G>A	ENST00000302555.5	-	2	200	c.51C>T	c.(49-51)gcC>gcT	p.A17A	GP2_ENST00000341642.5_Silent_p.A17A|GP2_ENST00000381360.5_Silent_p.A17A|GP2_ENST00000381362.4_Silent_p.A17A			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	17						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGGAGACCAAGGCCAGCCACA	0.532000													18	46					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121420752	121420752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121420752C>T	ENST00000260197.7	+	15	2264	c.2135C>T	c.(2134-2136)cCt>cTt	p.P712L		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	712					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TCATACTCCCCTCCTGTGCCT	0.488000													30	101					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578102	9578102	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9578102C>T	ENST00000301480.4	-	10	1734	c.1521G>A	c.(1519-1521)ttG>ttA	p.L507L		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TGTGAGTTCTCAAATGAGCAA	0.408000													43	102					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21866051	21866051	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21866051C>G	ENST00000399982.2	-	26	5046	c.4982G>C	c.(4981-4983)gGc>gCc	p.G1661A	CHD8_ENST00000430710.3_Missense_Mutation_p.G1382A|CHD8_ENST00000555962.1_5'UTR|CHD8_ENST00000557364.1_Missense_Mutation_p.G1661A	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1661					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ATCTGGTCGGCCAGCCTTTTC	0.393000													5	22					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26112152	26112152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:26112152C>T	ENST00000381655.2	+	7	676	c.534C>T	c.(532-534)gtC>gtT	p.V178V	ATP8A2_ENST00000255283.8_Silent_p.V138V	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	138					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TTGTGAAGGTCGTCAATGGGC	0.448000													17	55					0	0	1	0	0
PLEKHA1	59338	broad.mit.edu	37	10	124189150	124189150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124189150C>T	ENST00000368988.1	+	13	1075	c.952C>T	c.(952-954)Ccg>Tcg	p.P318S	PLEKHA1_ENST00000368989.2_Missense_Mutation_p.P318S|PLEKHA1_ENST00000368990.3_Missense_Mutation_p.P304L|PLEKHA1_ENST00000433307.1_Missense_Mutation_p.P304L|PLEKHA1_ENST00000538022.1_3'UTR			Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0					B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	13		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GAGCATCCCCCCGGTCCTTCA	0.507000													11	37					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68704332	68704332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68704332C>T	ENST00000255078.3	+	13	2495	c.2384C>T	c.(2383-2385)cCc>cTc	p.P795L		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	795	Gln/Pro-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCCCTGGGACCCCCAGCAGGG	0.706000													12	24					0	0	1	0	0
HIST2H2BA	337875	broad.mit.edu	37	1	120906269	120906269	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120906269G>A	ENST00000430394.1	+	0	242					NR_027337.1																						CGCATCGCGGGAGAGGCGTCC	0.642000													36	105					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756624	15756624	+	Silent	SNP	C	C	T	rs116936513	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15756624C>T	ENST00000221307.7	+	3	342	c.294C>T	c.(292-294)atC>atT	p.I98I	CYP4F3_ENST00000586182.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000591058.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	98					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding	p.I98I(1)		endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GGCACGCAATCGTCCGCATCT	0.582000													21	43					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	892285	892285	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:892285C>T	ENST00000456758.2	+	14	1458	c.1458C>T	c.(1456-1458)atC>atT	p.I486I	SUN1_ENST00000425407.2_Silent_p.I214I|SUN1_ENST00000405266.1_Silent_p.I334I|SUN1_ENST00000452783.2_Silent_p.I195I|SUN1_ENST00000413514.2_Silent_p.I106I|SUN1_ENST00000389574.3_Silent_p.I214I|SUN1_ENST00000401592.1_Silent_p.I297I			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	324					cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TCTTGCTCATCCCACTCTTCC	0.418000													44	149					0	0	1	0	0
TRIM60	166655	broad.mit.edu	37	4	165962195	165962195	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:165962195G>A	ENST00000512596.1	+	3	1187	c.971G>A	c.(970-972)cGa>cAa	p.R324Q	TRIM60_ENST00000508504.1_Missense_Mutation_p.R324Q|TRIM60_ENST00000341062.5_Missense_Mutation_p.R324Q	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	324	B30.2/SPRY.					intracellular	zinc ion binding	p.R324Q(1)		NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		AGAAAAAAACGAAACATTTGT	0.418000													25	109					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110032729	110032729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110032729C>T	ENST00000369870.3	+	8	1230	c.1215C>T	c.(1213-1215)acC>acT	p.T405T		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	405										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		ATTATGCAACCCGGCCCCCAC	0.662000													22	65					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100950384	100950384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100950384C>T	ENST00000335290.6	+	4	1250	c.1024C>T	c.(1024-1026)Cat>Tat	p.H342Y	WDR25_ENST00000554998.1_Missense_Mutation_p.H342Y|WDR25_ENST00000542471.2_Missense_Mutation_p.H85Y|WDR25_ENST00000402312.3_Missense_Mutation_p.H342Y	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	342										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				CTTGAAATTCCATCCAAAAGA	0.398000													46	127					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171765837	171765837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:171765837G>A	ENST00000311601.5	-	13	2442	c.2272C>T	c.(2272-2274)Cca>Tca	p.P758S	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	758	Pro-rich.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTGCGGGGTGGGACCACAGGT	0.617000													14	50					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760080	115760080	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:115760080C>T	ENST00000427548.1	-	0	1733							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										TCAGTACATTCATATGGTTTC	0.403000													7	64					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46094037	46094037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46094037C>T	ENST00000323040.4	-	2	2032	c.1088G>A	c.(1087-1089)tGa>tAa	p.*363*	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	0						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		ACTCGGGGTTCATTGTGCTGG	0.577000													22	46					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123971140	123971140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123971140C>T	ENST00000369005.1	+	9	7540	c.7200C>T	c.(7198-7200)atC>atT	p.I2400I	TACC2_ENST00000368999.1_Silent_p.I478I|TACC2_ENST00000369004.3_Silent_p.I478I|TACC2_ENST00000513429.1_Silent_p.I546I|TACC2_ENST00000358010.1_Silent_p.I546I|TACC2_ENST00000369000.1_Silent_p.I104I|TACC2_ENST00000515603.1_Silent_p.I2355I|TACC2_ENST00000369001.1_Silent_p.I104I|TACC2_ENST00000334433.3_Silent_p.I2400I|TACC2_ENST00000360561.3_Silent_p.I478I|TACC2_ENST00000515273.1_Silent_p.I2404I|TACC2_ENST00000453444.2_Silent_p.I2404I|TACC2_ENST00000260733.3_Silent_p.I478I	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2400	SPAZ.					microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCTTTGAGATCCCAGCCAGTG	0.532000													30	104					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188243719	188243719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:188243719C>T	ENST00000409998.1	-	9	1229	c.448G>A	c.(448-450)Gga>Aga	p.G150R	AC007319.1_ENST00000453517.1_RNA|CALCRL_ENST00000392370.3_Missense_Mutation_p.G150R|CALCRL_ENST00000410068.1_Missense_Mutation_p.G150R|AC007319.1_ENST00000412276.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	150						integral to plasma membrane		p.G150*(1)		endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			ATAGACAATCCGTGTCCAATT	0.294000													18	167					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2430192	2430192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2430192C>T	ENST00000449969.1	+	18	2439	c.2278C>T	c.(2278-2280)Ccc>Tcc	p.P760S	PLCH2_ENST00000288766.5_Missense_Mutation_p.P75S|PLCH2_ENST00000378488.3_Missense_Mutation_p.P751S|PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000419816.2_Missense_Mutation_p.P787S|PLCH2_ENST00000378486.3_Missense_Mutation_p.P787S			O75038	PLCH2_HUMAN	phospholipase C, eta 2	787	C2.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GATCATCGACCCCTTTGTGGA	0.687000													6	15					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30961728	30961728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30961728C>T	ENST00000311813.4	+	2	487	c.432C>T	c.(430-432)atC>atT	p.I144I	AQP1_ENST00000434909.2_Silent_p.I204I|AQP1_ENST00000441328.2_Silent_p.I61I|AQP1_ENST00000409899.1_Silent_p.I29I|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Silent_p.I93I|AQP1_ENST00000509504.1_Silent_p.I321I	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				TCGAGATCATCGGGACCCTCC	0.657000													16	67					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57429363	57429363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57429363G>A	ENST00000371100.4	+	1	1595	c.1043G>A	c.(1042-1044)cGa>cAa	p.R348Q	GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371075.3_Intron|GNAS_ENST00000371099.2_Missense_Mutation_p.R348Q|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371102.4_Missense_Mutation_p.R348Q|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000306120.3_Missense_Mutation_p.E285K|GNAS_ENST00000603534.1_Intron	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AAGAGAGAGCGAGCAGAGAGA	0.642000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			6	13					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56137167	56137167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56137167G>A	ENST00000319441.4	+	3	429	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K	PCK1_ENST00000543666.1_Intron|PCK1_ENST00000535860.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	89					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GGCCAGGATCGAAAGCAAGAC	0.557000													15	40					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929478	121929478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:121929478G>A	ENST00000265922.3	-	8	2631	c.2170C>T	c.(2170-2172)Ctg>Ttg	p.L724L	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		724					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CGGTGTTTCAGCATACAGGAG	0.552000													61	114					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451427	55451427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55451427C>T	ENST00000588756.1	-	6	1246	c.760G>A	c.(760-762)Ggc>Agc	p.G254S	NLRP7_ENST00000328092.5_Missense_Mutation_p.G254S|NLRP7_ENST00000340844.2_Missense_Mutation_p.G254S|NLRP7_ENST00000448121.2_Missense_Mutation_p.G254S|NLRP7_ENST00000590030.1_Missense_Mutation_p.G254S|NLRP7_ENST00000592784.1_Missense_Mutation_p.G254S|NLRP7_ENST00000446217.1_Missense_Mutation_p.G282S			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	254	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TCATCAAGGCCATCGACCACG	0.562000													43	106					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729527	18729527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18729527C>T	ENST00000440756.2	-	3	949	c.847G>A	c.(847-849)Gga>Aga	p.G283R	PSD3_ENST00000327040.8_Missense_Mutation_p.G283R|PSD3_ENST00000523619.1_Missense_Mutation_p.G218R			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	283					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CGATCACATCCCCCTGGGTGC	0.562000													7	108					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229772656	229772656	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:229772656C>T	ENST00000258243.2	+	4	2432	c.2296C>T	c.(2296-2298)Ctg>Ttg	p.L766L		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	766						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GGCCAGTGTCCTGCTGAGAAC	0.448000													29	66					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16908679	16908679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16908679C>T	ENST00000524140.2	+	16	3859	c.3441C>T	c.(3439-3441)tcC>tcT	p.S1147S	NWD1_ENST00000523826.1_Silent_p.S941S|NWD1_ENST00000379808.3_Silent_p.S1147S|NWD1_ENST00000552788.1_Silent_p.S1147S|NWD1_ENST00000339803.6_Silent_p.S1012S|NWD1_ENST00000549814.1_Silent_p.S1147S	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1147							ATP binding	p.S1012S(1)|p.S1147S(1)		NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCACGGGGTCCCTTGATGCGC	0.522000													67	231					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111317719	111317719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111317719C>T	ENST00000308208.5	+	6	741	c.499C>T	c.(499-501)Cac>Tac	p.H167Y	CCDC63_ENST00000550317.1_Intron|CCDC63_ENST00000552694.1_Missense_Mutation_p.H88Y|CCDC63_ENST00000545036.1_Missense_Mutation_p.H127Y	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	167										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GGTCACTGTTCACTTTGACAA	0.468000													44	128					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46407393	46407393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:46407393C>T	ENST00000433765.2	-	1	714	c.715G>A	c.(715-717)Gcc>Acc	p.A239T		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	239					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	AGCGTCTTGGCTTTCTTCTCC	0.642000													5	5					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325627	79325627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79325627G>A	ENST00000428286.1	-	8	1686	c.486C>T	c.(484-486)ttC>ttT	p.F162F	PRUNE2_ENST00000376718.3_Silent_p.F521F			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	521					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity	p.F521L(1)		endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TGTTGGGGAAGAAGTCATCTG	0.512000													9	21					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	8000004	8000004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8000004G>A	ENST00000377507.3	-	2	217	c.51C>T	c.(49-51)aaC>aaT	p.N17N		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	17					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTCTCAAAGTTGAGGACCA	0.443000													18	41					0	0	1	0	0
FAM187B	148109	broad.mit.edu	37	19	35715768	35715768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35715768G>A	ENST00000324675.3	-	2	1118	c.1070C>T	c.(1069-1071)tCc>tTc	p.S357F		NM_152481.1	NP_689694.1	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	357						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	9						CCTGCCCGGGGAAGGGTGGAT	0.677000													19	26					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145562712	145562712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145562712G>A	ENST00000355594.4	+	10	2487	c.2400G>A	c.(2398-2400)atG>atA	p.M800I		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	800										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AGGCCACGATGAGCGGGAAGA	0.637000													9	25					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113802129	113802129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113802129G>A	ENST00000260191.2	+	3	494	c.237G>A	c.(235-237)aaG>aaA	p.K79K	HTR3B_ENST00000537778.1_Silent_p.K68K	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	79					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		AAATATTAAAGACAAGTGTAT	0.318000													15	37					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69669638	69669638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69669638G>A	ENST00000194900.4	+	5	1027	c.686G>A	c.(685-687)cGa>cAa	p.R229Q	DLG3_ENST00000374360.3_Missense_Mutation_p.R211Q			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	211	PDZ 2.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					CCTGTGGTGCGATTGGTGGTG	0.642000													3	10					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39495059	39495059	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39495059T>C	ENST00000265707.5	+	9	709	c.664T>C	c.(664-666)Ttt>Ctt	p.F222L	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.F198L	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	222	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TTTTTAGATGTTTACCCAGTT	0.294000													9	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083644	9083644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9083644G>A	ENST00000397910.4	-	1	8374	c.8171C>T	c.(8170-8172)cCt>cTt	p.P2724L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2724	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTGGAAGAAGGATGGAGTGG	0.468000													28	90					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69046420	69046420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69046420G>A	ENST00000295381.3	+	9	1585	c.1166G>A	c.(1165-1167)cGa>cAa	p.R389Q	ARHGAP25_ENST00000497079.1_Missense_Mutation_p.R383Q|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.R83Q|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.R350Q|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.R383Q|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.R382Q|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.R390Q	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	389					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						GAAGACCTCCGAATTTCTAGG	0.532000													38	81					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111966270	111966270	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111966270G>A	ENST00000369732.3	-	5	433	c.378C>T	c.(376-378)tcC>tcT	p.S126S	OVGP1_ENST00000540696.1_Silent_p.S66S	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	126					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TCCTCAGAAGGGATATAACTG	0.443000													45	70					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21208825	21208825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21208825C>T	ENST00000574002.1	-	20	2696	c.2214G>A	c.(2212-2214)gaG>gaA	p.E738E	ZP2_ENST00000219593.4_Silent_p.E738E|ZP2_ENST00000574091.1_Silent_p.E729E|AF001550.7_ENST00000572747.1_RNA			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	738					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		CAGTCCTTTTCTCGTACAGGT	0.453000													11	77					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71329576	71329576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71329576G>A	ENST00000260382.5	+	15	2022	c.1762G>A	c.(1762-1764)Gaa>Aaa	p.E588K	LRRC49_ENST00000544974.2_Missense_Mutation_p.E578K|LRRC49_ENST00000560691.1_Missense_Mutation_p.E294K|LRRC49_ENST00000443425.2_Missense_Mutation_p.E544K|LRRC49_ENST00000560369.1_Missense_Mutation_p.E593K|LRRC49_ENST00000560158.2_Missense_Mutation_p.E276K|LRRC49_ENST00000436542.2_3'UTR	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	588						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						TATTATCAACGAAGAAAATAA	0.313000													50	171					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	48996764	48996764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48996764G>A	ENST00000226432.4	+	5	823	c.640G>A	c.(640-642)Gga>Aga	p.G214R	CWH43_ENST00000513409.1_Missense_Mutation_p.G187R	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	214					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						CTGGGTTTTTGGAGAAGTCTC	0.547000													46	116					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77918525	77918525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77918525G>A	ENST00000302536.2	+	7	1056	c.903G>A	c.(901-903)gtG>gtA	p.V301V		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	301							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						TGGAGAAGGTGAACCCCATCA	0.512000													10	15					0	0	1	0	0
UBE2U	148581	broad.mit.edu	37	1	64707407	64707407	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:64707407G>A	ENST00000371077.4	+	8	1092	c.668G>A	c.(667-669)tGg>tAg	p.W223*	UBE2U_ENST00000464349.1_3'UTR|UBE2U_ENST00000371076.3_Nonsense_Mutation_p.W223*			Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)	223							ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(3)|lung(2)|skin(1)	6						CAGAAAGAATGGAATTTAAAG	0.299000													11	43					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75831063	75831063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:75831063G>A	ENST00000322507.8	-	44	7350	c.7041C>T	c.(7039-7041)ttC>ttT	p.F2347F	COL12A1_ENST00000483888.2_Silent_p.F2347F|COL12A1_ENST00000416123.2_Silent_p.F2347F|COL12A1_ENST00000345356.6_Silent_p.F1183F	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2347	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCACAGTATTGAAGATGAATT	0.438000													12	78					0	0	1	0	0
SLC39A10	57181	broad.mit.edu	37	2	196581607	196581607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196581607C>T	ENST00000409086.3	+	7	2218	c.1943C>T	c.(1942-1944)tCt>tTt	p.S648F	SLC39A10_ENST00000541054.1_Missense_Mutation_p.S198F|SLC39A10_ENST00000359634.5_Missense_Mutation_p.S648F	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	648	His-rich.				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			CACAAGCATTCTCATCATTCC	0.488000													21	108					0	0	1	0	0
TLE2	7089	broad.mit.edu	37	19	3006496	3006496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3006496C>T	ENST00000262953.6	-	15	1684	c.1422G>A	c.(1420-1422)acG>acA	p.T474T	TLE2_ENST00000591529.1_Silent_p.T488T|TLE2_ENST00000590536.1_Silent_p.T475T|TLE2_ENST00000586422.1_Intron|TLE2_ENST00000455444.2_Silent_p.T352T|TLE2_ENST00000447365.2_Silent_p.T141T|TLE2_ENST00000443826.3_Silent_p.T352T|TLE2_ENST00000426948.2_Silent_p.T488T	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	474					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTGCCGCCCGTGTACACAT	0.716000													5	17					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348695	140348695	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348695C>T	ENST00000289269.5	+	1	2876	c.2344C>T	c.(2344-2346)Cga>Tga	p.R782*	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		782					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTGAAGTTCGAGGGAATGG	0.507000													21	58					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7697666	7697666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7697666C>T	ENST00000572933.1	+	49	9124	c.7664C>T	c.(7663-7665)aCc>aTc	p.T2555I	DNAH2_ENST00000389173.2_Missense_Mutation_p.T2555I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2555	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ATCAACATGACCTTCCCCACA	0.602000													21	27					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106321778	106321778	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106321778C>T	ENST00000390559.2	-	0	455																											CCACCTGCTTCCCCTCGCGCA	0.642000													13	41					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25671518	25671518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25671518C>T	ENST00000281589.3	+	1	1219	c.1182C>T	c.(1180-1182)aaC>aaT	p.N394N		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	394					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CTGTGCCCAACCAGCGAGCAC	0.498000													35	95					0	0	1	0	0
PRKCE	5581	broad.mit.edu	37	2	46237648	46237648	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:46237648C>T	ENST00000306156.3	+	10	1756	c.1429C>T	c.(1429-1431)Cag>Tag	p.Q477*	PRKCE_ENST00000394874.1_Nonsense_Mutation_p.Q200*	NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	477	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity		MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CTGCTGCTTCCAGACCAAGGT	0.473000													9	68					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158505106	158505106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:158505106C>T	ENST00000355585.4	+	22	3183	c.3108C>T	c.(3106-3108)ctC>ctT	p.L1036L	SYNJ2_ENST00000367122.2_Silent_p.L1036L|SYNJ2_ENST00000367121.3_Silent_p.L1036L|SYNJ2_ENST00000367112.1_Silent_p.L121L	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	1036							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		ACAGTGAACTCGGGGGAGACG	0.517000													106	157					0	0	1	0	0
CCL25	6370	broad.mit.edu	37	19	8121312	8121312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8121312G>A	ENST00000253451.4	+	4	360	c.254G>A	c.(253-255)aGa>aAa	p.R85K	CCL25_ENST00000315626.4_Intron|CCL25_ENST00000390669.3_Missense_Mutation_p.R85K	NM_001201359.1|NM_005624.3	NP_001188288.1|NP_005615.2	O15444	CCL25_HUMAN	chemokine (C-C motif) ligand 25	85					chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|hormone activity			NS(1)|endometrium(1)|lung(1)|skin(1)|urinary_tract(1)	5						GAGGTGCAGAGAGCCATGAAG	0.557000													11	32					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36766013	36766013	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36766013G>A	ENST00000244751.2	-	6	957	c.333C>T	c.(331-333)ttC>ttT	p.F111F		NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	111	C2 1.									central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CCTGGCCCAGGAAATCCTGCA	0.602000													8	20					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155528041	155528041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155528041G>A	ENST00000404648.3	-	8	1184	c.945C>T	c.(943-945)gcC>gcT	p.A315A	FGG_ENST00000407946.1_Silent_p.A323A|FGG_ENST00000336098.3_Silent_p.A315A|FGG_ENST00000405164.1_Silent_p.A323A	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	315	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AGCCATCAAAGGCATCTCCAG	0.463000													56	95					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47678608	47678608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47678608G>A	ENST00000283303.2	+	4	544	c.286G>A	c.(286-288)Gaa>Aaa	p.E96K	GPR115_ENST00000371220.1_Missense_Mutation_p.E153K|GPR115_ENST00000327753.3_Missense_Mutation_p.E96K	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	96					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CCTTTCTGTGGAAAAACTCTT	0.393000													32	65					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17614116	17614116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:17614116G>A	ENST00000377813.1	-	8	2902	c.2599C>T	c.(2599-2601)Ctg>Ttg	p.L867L	RRBP1_ENST00000360807.4_Silent_p.L434L|RRBP1_ENST00000455029.2_Silent_p.L208L|RRBP1_ENST00000246043.4_Silent_p.L867L|RRBP1_ENST00000377807.2_Silent_p.L434L			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	867					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						TGCAGCTGCAGGACCTGCTTC	0.642000													8	70					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76468259	76468259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:76468259G>A	ENST00000396423.2	+	6	782	c.658G>A	c.(658-660)Gga>Aga	p.G220R	HNF4G_ENST00000354370.1_Missense_Mutation_p.G183R	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	183					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			CTTACTGCTTGGAGCTACAAA	0.289000													15	65					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47746591	47746591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47746591G>A	ENST00000273857.4	-	5	626	c.627C>T	c.(625-627)ctC>ctT	p.L209L	CORIN_ENST00000504584.1_Silent_p.L209L|CORIN_ENST00000502252.1_Silent_p.L142L|CORIN_ENST00000505909.1_Silent_p.L209L|CORIN_ENST00000508498.1_Silent_p.L70L	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	209	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TACAGGGCAGGAGTCCATGAC	0.418000													13	139					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20620576	20620576	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20620576T>C	ENST00000504154.1	+	37	4786	c.4534T>C	c.(4534-4536)Ttt>Ctt	p.F1512L	SLIT2_ENST00000273739.5_Missense_Mutation_p.F1525L|SLIT2_ENST00000503823.1_Missense_Mutation_p.F1504L|SLIT2_ENST00000503837.1_Missense_Mutation_p.F1508L	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1512	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CGGCTCCTCCTTTGTGGACGA	0.547000													22	32					0	0	1	0	0
OR2K2	26248	broad.mit.edu	37	9	114090282	114090282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114090282C>T	ENST00000374428.1	-	1	518	c.519G>A	c.(517-519)atG>atA	p.M173I	OR2K2_ENST00000302681.1_Missense_Mutation_p.M144I			Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)	20						AGACCGTAGCCATCCGTGCAC	0.547000													29	70					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55615680	55615680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55615680G>A	ENST00000326258.1	+	1	872	c.872G>A	c.(871-873)gGc>gAc	p.G291D		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G291V(1)		endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						ATCATCTACGGCCTGAGGAAC	0.448000													24	58					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139657446	139657446	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139657446C>T	ENST00000263552.6	+	12	1243	c.705C>T	c.(703-705)tcC>tcT	p.S235S	TBXAS1_ENST00000448866.1_Silent_p.S234S|TBXAS1_ENST00000436047.2_Silent_p.S235S|TBXAS1_ENST00000414508.2_Silent_p.S235S|TBXAS1_ENST00000416849.2_Silent_p.S281S|TBXAS1_ENST00000425687.1_Silent_p.S167S|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000411653.1_Silent_p.S234S|TBXAS1_ENST00000458722.1_Silent_p.S280S|TBXAS1_ENST00000336425.5_Silent_p.S234S	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	234					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CATTTCCATCCATAATGGTCC	0.458000													24	67					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30532907	30532907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30532907C>T	ENST00000356798.6	+	31	3614	c.3434C>T	c.(3433-3435)tCt>tTt	p.S1145F	ITGAL_ENST00000358164.5_Missense_Mutation_p.S1061F|ITGAL_ENST00000433423.2_Missense_Mutation_p.S379F	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1145					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CAGCTGGCATCTGGGCAAGAG	0.582000													35	79					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9370586	9370586	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9370586T>C	ENST00000378501.2	+	13	1234	c.1219T>C	c.(1219-1221)Tcc>Ccc	p.S407P	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.S407P|PLCB4_ENST00000278655.4_Missense_Mutation_p.S407P|PLCB4_ENST00000378493.1_Missense_Mutation_p.S407P|PLCB4_ENST00000334005.3_Missense_Mutation_p.S407P|PLCB4_ENST00000378473.3_Missense_Mutation_p.S407P	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	407	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TGTAATTCTCTCCTTTGAAAA	0.368000													27	93					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71555572	71555572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71555572C>T	ENST00000265382.3	+	14	1673	c.1368C>T	c.(1366-1368)tcC>tcT	p.S456S	PIP5K1B_ENST00000541509.1_Silent_p.S456S	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	456						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		CCCTGGGATCCCGACACAGGC	0.433000													32	147					0	0	1	0	0
WDR18	57418	broad.mit.edu	37	19	990989	990989	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:990989C>T	ENST00000251289.5	+	5	758	c.735C>T	c.(733-735)ttC>ttT	p.F245F	WDR18_ENST00000587001.2_Silent_p.F245F	NM_024100.3	NP_077005.2	Q9BV38	WDR18_HUMAN	WD repeat domain 18	245										endometrium(1)|kidney(2)|lung(2)|skin(2)	7		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGACCTCTTCACCTGGGTGA	0.652000													15	34					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35781030	35781030	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:35781030C>T	ENST00000187397.4	+	17	2322	c.1866C>T	c.(1864-1866)ccC>ccT	p.P622P	ARPP21_ENST00000458225.1_Silent_p.P623P|ARPP21_ENST00000417925.1_Silent_p.P623P|ARPP21_ENST00000444190.1_Silent_p.P603P|ARPP21_ENST00000337271.5_Silent_p.P603P	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	622	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						AGCCCCCTCCCTCACCACAGG	0.562000													23	49					0	0	1	0	0
SLC8B1	80024	broad.mit.edu	37	12	113754419	113754419	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113754419G>A	ENST00000552014.1	-	11	1420	c.905C>T	c.(904-906)gCt>gTt	p.A302V	SLC24A6_ENST00000546737.1_Missense_Mutation_p.A246V|SLC24A6_ENST00000202831.3_Missense_Mutation_p.A302V|SLC24A6_ENST00000553238.1_5'UTR			Q6J4K2	NCKX6_HUMAN		302					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						CAGGATCTGAGCCGTGGTCTC	0.577000													32	273					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81111096	81111096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81111096G>A	ENST00000228644.3	+	1	406	c.254G>A	c.(253-255)cGg>cAg	p.R85Q		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	85					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						ATGGATCGGCGGAAGGCAGCC	0.627000													15	32					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491719	100491719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100491719C>T	ENST00000302913.4	-	2	273	c.135G>A	c.(133-135)ggG>ggA	p.G45G	ACHE_ENST00000428317.1_Silent_p.G45G|ACHE_ENST00000412389.1_Silent_p.G45G|ACHE_ENST00000411582.1_Silent_p.G45G|ACHE_ENST00000241069.5_Silent_p.G45G|ACHE_ENST00000419336.2_Silent_p.G45G	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	45					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GCAGCCGGCCCCCACGCACCG	0.697000													3	15					0	0	1	0	0
FRS2	10818	broad.mit.edu	37	12	69965947	69965947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:69965947C>T	ENST00000299293.2	+	9	972	c.462C>T	c.(460-462)ccC>ccT	p.P154P	FRS2_ENST00000397997.2_Silent_p.P154P|FRS2_ENST00000550389.1_Silent_p.P154P|FRS2_ENST00000549921.1_Silent_p.P154P	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	154					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			CCCGATATCCCTCATTTGGAG	0.483000													25	79					0	0	1	0	0
IGHV4-59	28392	broad.mit.edu	37	14	107083553	107083553	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107083553G>A	ENST00000455737.1	-	0	90																											CCTGGGACAGGACCCCTGTGA	0.602000													15	46					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44083474	44083474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44083474C>T	ENST00000359947.4	+	25	4603	c.4263C>T	c.(4261-4263)atC>atT	p.I1421I	PTPRF_ENST00000422171.2_Silent_p.I780I|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Silent_p.I1412I|PTPRF_ENST00000372414.3_Silent_p.I1421I|PTPRF_ENST00000438120.1_Silent_p.I1412I	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1421	Tyrosine-protein phosphatase 1.			I -> T (in Ref. 5; AAH48768).	transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATGCCTACATCGCCACGCAGG	0.582000													15	51					0	0	1	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806871	97806871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97806871C>T	ENST00000358642.2	+	1	855	c.855C>T	c.(853-855)ccC>ccT	p.P285P		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						TTATAATTCCCCTGCTAAACC	0.373000													16	48					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74868895	74868895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74868895C>T	ENST00000428789.2	+	1	167	c.64C>T	c.(64-66)Ctt>Ttt	p.L22F	MGAT5B_ENST00000374998.3_Intron|MGAT5B_ENST00000565675.1_Intron|MGAT5B_ENST00000301618.4_Intron|MGAT5B_ENST00000569840.2_Intron	NM_198955.1	NP_945193.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	12						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CACGATGGCCCTTCCTGCCCT	0.577000													9	38					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139719887	139719887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139719887C>T	ENST00000263552.6	+	17	2131	c.1593C>T	c.(1591-1593)atC>atT	p.I531I	TBXAS1_ENST00000448866.1_Silent_p.I530I|TBXAS1_ENST00000436047.2_Silent_p.I531I|TBXAS1_ENST00000414508.2_3'UTR|TBXAS1_ENST00000416849.2_Silent_p.I577I|TBXAS1_ENST00000425687.1_Silent_p.I463I|TBXAS1_ENST00000411653.1_3'UTR|TBXAS1_ENST00000458722.1_Silent_p.I576I|TBXAS1_ENST00000336425.5_Silent_p.I530I	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	530					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					ATATCAAGATCGTATCCCGCT	0.428000													19	47					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13764672	13764672	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13764672G>A	ENST00000279593.3	-	8	1976	c.1767C>T	c.(1765-1767)ctC>ctT	p.L589L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	589					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGCCATCAGCGAGGCACCTGT	0.483000													19	92					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184075040	184075040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184075040G>A	ENST00000265593.4	-	9	1084	c.913C>T	c.(913-915)Ctc>Ttc	p.L305F	EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000344937.7_Missense_Mutation_p.L305F|CLCN2_ENST00000434054.2_Missense_Mutation_p.L261F|CLCN2_ENST00000457512.1_Missense_Mutation_p.L305F|CLCN2_ENST00000423355.2_5'UTR	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	305						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GTTTTGAAGAGGGCTGTAATA	0.612000													27	59					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508190	37508190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37508190G>A	ENST00000374660.1	+	40	3838	c.3739G>A	c.(3739-3741)Gaa>Aaa	p.E1247K	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1128K|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1128K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1184						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TAAATTGAAGGAAAAACAAGA	0.368000													10	146					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76395319	76395319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76395319C>T	ENST00000357063.3	+	15	3630	c.2370C>T	c.(2368-2370)tcC>tcT	p.S790S	LMO7_ENST00000377534.3_Silent_p.S790S|LMO7_ENST00000321797.8_Silent_p.S505S|LMO7_ENST00000526202.1_Silent_p.S355S|LMO7_ENST00000341547.4_Silent_p.S456S|LMO7_ENST00000465261.2_Silent_p.S505S			Q8WWI1	LMO7_HUMAN	LIM domain 7	790						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TAAGGGAATCCCAAAATCAAA	0.453000													12	31					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618198	77618198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77618198G>A	ENST00000521891.2	+	2	2323	c.1875G>A	c.(1873-1875)tcG>tcA	p.S625S	ZFHX4_ENST00000455469.2_Silent_p.S625S|ZFHX4_ENST00000050961.6_Silent_p.S625S|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Silent_p.S625S	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	625						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGGGGTCTTCGAGGTCTCTTG	0.532000										HNSCC(33;0.089)			19	48					0	0	1	0	0
ABHD6	57406	broad.mit.edu	37	3	58271159	58271159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58271159C>T	ENST00000478253.1	+	9	1317	c.816C>T	c.(814-816)atC>atT	p.I272I	ABHD6_ENST00000295962.4_Silent_p.I272I			Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	272						integral to membrane	acylglycerol lipase activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	16				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)		CGACGCAGATCATCTGGGGGA	0.483000													21	64					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233704569	233704569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233704569C>T	ENST00000373566.3	+	24	3040	c.2843C>T	c.(2842-2844)tCt>tTt	p.S948F	GIGYF2_ENST00000409480.1_Missense_Mutation_p.S948F|GIGYF2_ENST00000409547.1_Missense_Mutation_p.S926F|GIGYF2_ENST00000452341.2_Missense_Mutation_p.S757F|GIGYF2_ENST00000409451.3_Missense_Mutation_p.S947F|GIGYF2_ENST00000409196.3_Missense_Mutation_p.S920F|GIGYF2_ENST00000373563.4_Missense_Mutation_p.S926F			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	926	Gln-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CTTCCTTCTTCTTCAACGTGG	0.453000													12	55					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17053020	17053020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:17053020C>T	ENST00000418129.2	+	2	2269	c.1804C>T	c.(1804-1806)Ctc>Ttc	p.L602F	PLCL2_ENST00000396755.2_Missense_Mutation_p.L602F|PLCL2_ENST00000432376.1_Missense_Mutation_p.L602F	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	728					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TGGCTATGTCCTCCGGCCAGC	0.483000													23	66					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124377772	124377772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124377772G>A	ENST00000338354.3	+	38	4850	c.4744G>A	c.(4744-4746)Gag>Aag	p.E1582K	DMBT1_ENST00000344338.3_Missense_Mutation_p.E1572K|DMBT1_ENST00000368955.3_Missense_Mutation_p.E1572K|DMBT1_ENST00000359586.6_Missense_Mutation_p.E433K|DMBT1_ENST00000330163.4_Missense_Mutation_p.E954K|DMBT1_ENST00000368956.2_Missense_Mutation_p.E954K|DMBT1_ENST00000368909.3_Missense_Mutation_p.E1582K			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1582	SRCR 12.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTCAGGACACGAGTCTTACCT	0.597000													59	159					0	0	1	0	0
STXBP5	134957	broad.mit.edu	37	6	147685156	147685156	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:147685156C>T	ENST00000367481.3	+	23	2935	c.2827C>T	c.(2827-2829)Ctg>Ttg	p.L943L	STXBP5_ENST00000367480.3_Silent_p.L926L|STXBP5_ENST00000321680.6_Silent_p.L979L|STXBP5_ENST00000179882.6_Silent_p.L634L	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	979					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TTTAAGACCTCTGTTGGATGT	0.358000													74	107					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191385	152191385	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152191385C>T	ENST00000368801.2	-	3	2795	c.2720G>A	c.(2719-2721)gGc>gAc	p.G907D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	907					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCATGTCGGCCATAGCTGGG	0.652000													72	191					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43384806	43384806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43384806C>T	ENST00000372851.3	-	6	845	c.779G>A	c.(778-780)aGc>aAc	p.S260N	RIMS4_ENST00000541604.2_Missense_Mutation_p.S261N	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	260					exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				CCCCACGGTGCTCTCGAGGGA	0.677000													52	105					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96025687	96025687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96025687G>A	ENST00000260766.3	+	16	4887	c.4253G>A	c.(4252-4254)gGa>gAa	p.G1418E	PLCE1_ENST00000371380.2_Missense_Mutation_p.G1418E|PLCE1_ENST00000371375.1_Missense_Mutation_p.G1110E|PLCE1_ENST00000371385.3_Missense_Mutation_p.G1110E	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1418	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				CAGCTCAAAGGAGAATCCTCG	0.423000													34	71					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70871758	70871758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70871758G>A	ENST00000393567.2	-	77	13227	c.13077C>T	c.(13075-13077)ctC>ctT	p.L4359L		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	4359										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGTTCACCTCGAGGTGAGTGG	0.453000													24	46					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64873464	64873464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64873464G>A	ENST00000533854.1	+	2	251	c.14G>A	c.(13-15)gGg>gAg	p.G5E	CACNG5_ENST00000169565.3_Missense_Mutation_p.G5E|CACNG5_ENST00000307139.3_Missense_Mutation_p.G5E			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	5					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			AGTGCCTGCGGGAGGAAGGCC	0.632000													17	67					0	0	1	0	0
CLCN4	1183	broad.mit.edu	37	X	10176100	10176100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:10176100C>T	ENST00000380833.4	+	9	1250	c.859C>T	c.(859-861)Ccc>Tcc	p.P287S	CLCN4_ENST00000421085.2_Missense_Mutation_p.P193S|CLCN4_ENST00000380829.1_Missense_Mutation_p.P287S	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	287						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TTACTACTTTCCCCTGAAGAC	0.498000													66	99					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25886970	25886970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25886970G>A	ENST00000376351.3	+	11	2774	c.2415G>A	c.(2413-2415)gaG>gaA	p.E805E	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	805						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCAAGGAGGAGACCCTGAAAA	0.547000													44	121					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37036109	37036109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37036109C>T	ENST00000379242.3	+	15	2186	c.1884C>T	c.(1882-1884)gcC>gcT	p.A628A	VIT_ENST00000401530.1_Silent_p.A592A|VIT_ENST00000379241.3_Silent_p.A591A|VIT_ENST00000404084.1_Silent_p.A565A|VIT_ENST00000389975.3_Silent_p.A613A|VIT_ENST00000497382.1_Silent_p.A282A	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	613	VWFA 2.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				GGATCCCAGCCATGGCTGCCC	0.582000													14	37					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156642416	156642416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156642416C>T	ENST00000368223.3	-	4	1696	c.1564G>A	c.(1564-1566)Gaa>Aaa	p.E522K		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	522	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCCCATATTTCCTGCTGCAAG	0.483000													26	203					0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24839717	24839717	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24839717G>A	ENST00000413692.2	+	3	1446	c.1302G>A	c.(1300-1302)gaG>gaA	p.E434E	NFATC4_ENST00000556169.1_Silent_p.E359E|NFATC4_ENST00000556279.1_Silent_p.E403E|NFATC4_ENST00000554591.1_Silent_p.E434E|NFATC4_ENST00000555453.1_Silent_p.E359E|NFATC4_ENST00000422617.3_Silent_p.E359E|NFATC4_ENST00000440487.2_3'UTR|NFATC4_ENST00000554661.1_Silent_p.E301E|NFATC4_ENST00000424781.2_Silent_p.E384E|NFATC4_ENST00000553879.1_Silent_p.E301E|NFATC4_ENST00000554050.1_Silent_p.E371E|NFATC4_ENST00000554966.1_Silent_p.E384E|NFATC4_ENST00000553708.1_Silent_p.E371E|NFATC4_ENST00000539237.2_Silent_p.E403E|NFATC4_ENST00000250373.4_Silent_p.E371E|NFATC4_ENST00000553469.1_Silent_p.E403E|NFATC4_ENST00000555590.1_Silent_p.E384E|NFATC4_ENST00000554344.1_Silent_p.E301E|NFATC4_ENST00000557451.1_Silent_p.E301E	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	371	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CCCGGAAGGAGGTGGCTGGCA	0.642000													9	46					0	0	1	0	0
SLC44A3	126969	broad.mit.edu	37	1	95307561	95307561	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:95307561T>G	ENST00000271227.6	+	8	868	c.766T>G	c.(766-768)Tgc>Ggc	p.C256G	SLC44A3_ENST00000467909.1_Missense_Mutation_p.C208G|SLC44A3_ENST00000532427.1_Missense_Mutation_p.C176G|SLC44A3_ENST00000529450.1_Missense_Mutation_p.C224G|SLC44A3_ENST00000527077.1_Missense_Mutation_p.C188G|RP11-465K1.2_ENST00000422162.1_RNA|SLC44A3_ENST00000446120.2_Missense_Mutation_p.C220G|SLC44A3_ENST00000530397.1_3'UTR	NM_001114106.2|NM_001258340.1|NM_001258341.1	NP_001107578.1|NP_001245269.1|NP_001245270.1	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3	256						integral to membrane|plasma membrane	choline transmembrane transporter activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|prostate(2)|stomach(1)|urinary_tract(1)	23		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	TCTAGTTGTCTGCGGTGTTTT	0.483000													70	235					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58306080	58306080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:58306080C>T	ENST00000249750.4	-	3	1106	c.339G>A	c.(337-339)gtG>gtA	p.V113V	ALDH1A2_ENST00000537372.1_Silent_p.V92V|ALDH1A2_ENST00000558231.1_Silent_p.V84V|ALDH1A2_ENST00000559517.1_Silent_p.V17V|ALDH1A2_ENST00000347587.3_Silent_p.V113V	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	113					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TGTCCCGTTCCACCAAGTCTG	0.473000													128	343					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92577409	92577409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92577409C>T	ENST00000298047.6	+	18	10893	c.10876C>T	c.(10876-10878)Cgc>Tgc	p.R3626C	FAT3_ENST00000525166.1_Missense_Mutation_p.R3476C|FAT3_ENST00000409404.2_Missense_Mutation_p.R3626C			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3626	Cadherin 33.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAGTGATGGTCGCTTCCAGGT	0.502000										TCGA Ovarian(4;0.039)			81	155					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50740495	50740495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:50740495G>A	ENST00000008391.3	+	8	1505	c.1277G>A	c.(1276-1278)gGa>gAa	p.G426E		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	426							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TCTGGCCAAGGACATGCCAAC	0.488000													18	44					0	0	1	0	0
BTN2A1	11120	broad.mit.edu	37	6	26463639	26463639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26463639C>T	ENST00000429381.1	+	4	810	c.598C>T	c.(598-600)Ctc>Ttc	p.L200F	BTN2A1_ENST00000541522.1_Missense_Mutation_p.L139F|BTN2A1_ENST00000312541.5_Missense_Mutation_p.L200F|BTN2A1_ENST00000469185.1_Missense_Mutation_p.L200F			Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1	200					lipid metabolic process	integral to plasma membrane				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(3)	27						TGCAGACGGCCTCTTCATGGT	0.557000													38	114					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55003839	55003839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:55003839G>A	ENST00000474759.1	+	29	2572	c.2524G>A	c.(2524-2526)Gat>Aat	p.D842N	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.D748N|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.D842N|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.D842N	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	842						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGCTTCCCTGGATGGCAAATG	0.512000													24	29					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22922660	22922660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22922660G>A	ENST00000166244.3	+	9	1831	c.1759G>A	c.(1759-1761)Gga>Aga	p.G587R		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	587						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CTATCAGAATGGACAGGGTGA	0.652000													10	39					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167086743	167086743	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167086743G>A	ENST00000361200.2	+	4	550	c.384G>A	c.(382-384)gaG>gaA	p.E128E	DUSP27_ENST00000443333.1_Silent_p.E128E|DUSP27_ENST00000271385.5_Silent_p.E128E			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	128					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						ATCGCCAAGAGGCGCCCTGGA	0.547000													5	15					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111164437	111164437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111164437C>T	ENST00000360467.5	+	48	5344	c.5038C>T	c.(5038-5040)Ccc>Tcc	p.P1680S		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1680	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GACCACCATTCCCGAGCAGAG	0.612000													17	87					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237796914	237796914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237796914C>T	ENST00000366574.2	+	43	6909	c.6592C>T	c.(6592-6594)Cgt>Tgt	p.R2198C	RYR2_ENST00000542537.1_Missense_Mutation_p.R2182C|RYR2_ENST00000360064.6_Missense_Mutation_p.R2196C	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2198	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.R2196S(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAACTGTTGCCGTTTTCTCTG	0.388000													45	139					0	0	1	0	0
TINAGL1	64129	broad.mit.edu	37	1	32042974	32042974	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32042974C>T	ENST00000271064.7	+	2	301	c.225C>T	c.(223-225)ctC>ctT	p.L75L	TINAGL1_ENST00000441210.2_Silent_p.L75L|TINAGL1_ENST00000481165.1_3'UTR|TINAGL1_ENST00000457433.2_Silent_p.L75L|TINAGL1_ENST00000537531.1_Silent_p.L75L	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	75	SMB.				endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		ACTGTGACCTCTTCTGCAACC	0.657000													33	148					0	0	1	0	0
POMGNT1	55624	broad.mit.edu	37	1	46655138	46655138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46655138G>A	ENST00000371984.3	-	21	2044	c.1887C>T	c.(1885-1887)tcC>tcT	p.S629S	POMGNT1_ENST00000396420.3_3'UTR|POMGNT1_ENST00000371986.3_Intron|POMGNT1_ENST00000535522.1_Silent_p.S607S|POMGNT1_ENST00000371992.1_Intron	NM_017739.3	NP_060209.3	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	629					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					ACGAGTAGGGGGAAGCCGGGA	0.527000													10	19					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215640	140215640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140215640G>A	ENST00000525929.1	+	1	1672	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.E558K|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCTGGACGAGAACGACAA	0.692000													56	129					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141752740	141752740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141752740C>T	ENST00000475668.2	+	26	3169	c.3115C>T	c.(3115-3117)Cgc>Tgc	p.R1039C	MGAM_ENST00000549489.2_Missense_Mutation_p.R1039C			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1039					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GAACCCCCTTCGCCTGGATGT	0.458000													11	57					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42695454	42695454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42695454G>A	ENST00000358131.5	+	7	1595	c.1387G>A	c.(1387-1389)Gac>Aac	p.D463N	TOX2_ENST00000435864.2_Missense_Mutation_p.D359N|TOX2_ENST00000341197.3_Missense_Mutation_p.D481N|TOX2_ENST00000423191.1_Missense_Mutation_p.D439N|TOX2_ENST00000372999.1_Missense_Mutation_p.D439N	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CGGGGACTGGGACAGCAGCTA	0.637000													43	121					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28618127	28618127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28618127G>A	ENST00000395609.1	-	8	1307	c.549C>T	c.(547-549)agC>agT	p.S183S	SULT1A1_ENST00000350842.4_Silent_p.S105S|SULT1A1_ENST00000395607.1_Silent_p.S183S|SULT1A1_ENST00000569554.1_Silent_p.S183S|SULT1A1_ENST00000314752.7_Silent_p.S183S			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	183					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						GGTGGGTGCGGCTCAGCTCCC	0.597000													14	155					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139876656	139876656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139876656C>T	ENST00000297183.6	+	15	2921	c.2797C>T	c.(2797-2799)Cca>Tca	p.P933S	ANKHD1_ENST00000462121.1_3'UTR|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P933S|ANKHD1_ENST00000360839.2_Missense_Mutation_p.P933S	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTATCATCTCCACAGTGTAA	0.398000													60	170					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174689	207174689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207174689G>A	ENST00000374423.3	+	5	5823	c.5437G>A	c.(5437-5439)Gat>Aat	p.D1813N		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1813							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GGATAATCCTGATGAACCAGT	0.393000													28	55					0	0	1	0	0
SIX4	51804	broad.mit.edu	37	14	61187102	61187102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:61187102G>A	ENST00000216513.4	-	2	984	c.925C>T	c.(925-927)Cct>Tct	p.P309S		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	309						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		AGTGGGTGAGGAGATAAATCC	0.458000													42	92					0	0	1	0	0
NBL1	4681	broad.mit.edu	37	1	19981573	19981573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19981573C>T	ENST00000375136.3	+	2	353	c.50C>T	c.(49-51)gCt>gTt	p.A17V	NBL1_ENST00000548815.1_Missense_Mutation_p.A16V|MINOS1-NBL1_ENST00000602662.1_Missense_Mutation_p.A17V|NBL1_ENST00000289749.2_Missense_Mutation_p.A52V	NM_001204085.1|NM_001278164.1|NM_001278166.1	NP_001191014.1|NP_001265093.1|NP_001265095.1	P41271	NBL1_HUMAN	neuroblastoma 1, DAN family BMP antagonist	16						extracellular region				lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00043)|Ovarian(437;0.00373)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.9e-05)|Kidney(64;0.000173)|GBM - Glioblastoma multiforme(114;0.0012)|KIRC - Kidney renal clear cell carcinoma(64;0.0026)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ATGCTACTGGCTGCCCCACCA	0.627000													8	24					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26312975	26312975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26312975G>A	ENST00000265944.5	+	9	922	c.756G>A	c.(754-756)caG>caA	p.Q252Q	MYO3A_ENST00000543632.1_Silent_p.Q252Q	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	252	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AACTAAGGCAGCCTGAGCTAT	0.378000													55	141					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7720897	7720897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7720897C>T	ENST00000572933.1	+	66	11499	c.10039C>T	c.(10039-10041)Cct>Tct	p.P3347S	DNAH2_ENST00000389173.2_Missense_Mutation_p.P3347S			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3347					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCTTCAGGTTCCTTGCTCCCC	0.537000													70	63					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982672	36982672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36982672G>A	ENST00000274963.8	+	8	1058	c.887G>A	c.(886-888)cGg>cAg	p.R296Q		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	296					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						CCCTAGGAGCGGCTGCAGGAC	0.642000													18	49					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945668	72945668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72945668G>A	ENST00000311131.2	+	3	931	c.464G>A	c.(463-465)gGg>gAg	p.G155E	P2RY2_ENST00000393597.2_Missense_Mutation_p.G155E|P2RY2_ENST00000393596.2_Missense_Mutation_p.G155E	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	155					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	CGGGTGGCCGGGGCCGTGTGG	0.716000													13	69					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79108233	79108233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79108233G>A	ENST00000326724.4	-	2	148	c.124C>T	c.(124-126)Ctc>Ttc	p.L42F		NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	42						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			ACGGCGAAGAGCCCGGAGAAA	0.662000													12	25					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89619495	89619495	+	Silent	SNP	C	C	T	rs1050404		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89619495C>T	ENST00000268704.2	+	14	1903	c.1888C>T	c.(1888-1890)Ctg>Ttg	p.L630L		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	630					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GTGCATGGCCCTGGGAGGACG	0.622000													8	25					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099443	133099443	+	Silent	SNP	G	G	A	rs138205990	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133099443G>A	ENST00000515826.1	+	3	1011	c.888G>A	c.(886-888)ggG>ggA	p.G296G	TMEM108_ENST00000321871.6_Silent_p.G296G|TMEM108_ENST00000393130.3_Silent_p.G296G|TMEM108_ENST00000508711.1_Intron			Q6UXF1	TM108_HUMAN	transmembrane protein 108	296						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GCCAAGGAGGGACACCAGATG	0.662000													17	42					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43321774	43321774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43321774G>A	ENST00000380486.3	-	12	1758	c.1517C>T	c.(1516-1518)tCg>tTg	p.S506L	C2CD2_ENST00000329623.7_Missense_Mutation_p.S351L	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	506						cytosol|extracellular region|nucleus		p.S506L(1)		endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						CTTCCGTGGCGACTTGAGTTT	0.498000													21	75					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150739141	150739141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150739141G>A	ENST00000358849.4	+	14	1804	c.1711G>A	c.(1711-1713)Gcg>Acg	p.A571T	ABCB8_ENST00000542328.1_Missense_Mutation_p.A483T|ABCB8_ENST00000498578.1_Missense_Mutation_p.A571T|ABCB8_ENST00000356058.4_3'UTR|ABCB8_ENST00000297504.6_Missense_Mutation_p.A588T	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	588	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCCCGGGAAGCGAATGCTCA	0.612000													42	52					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139938380	139938380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139938380G>A	ENST00000357560.4	-	13	1694	c.1251C>T	c.(1249-1251)gcC>gcT	p.A417A	APBB3_ENST00000508496.2_Silent_p.A194A|APBB3_ENST00000412920.3_Silent_p.A415A|APBB3_ENST00000354402.5_Silent_p.A424A|APBB3_ENST00000356738.2_Silent_p.A422A|APBB3_ENST00000358580.5_3'UTR	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	417	PID 2.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGCAGAGGCCACAAGAC	0.627000													19	50					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409163	56409163	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56409163G>A	ENST00000544374.1	-	1	784	c.756C>T	c.(754-756)ctC>ctT	p.L252L	OR5AP2_ENST00000302981.1_Silent_p.L251L			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						TGACAGCCATGAGGTAAGAGG	0.458000													28	71					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289353	107289353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107289353G>A	ENST00000277216.3	-	1	137	c.138C>T	c.(136-138)atC>atT	p.I46I		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TGCTTGCTATGATCAGAACAC	0.433000													41	95					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82131918	82131918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82131918G>A	ENST00000199936.4	+	5	1234	c.1041G>A	c.(1039-1041)tgG>tgA	p.W347*	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	347					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	CTTACTTGTGGATCTGCCTTG	0.493000													40	92					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107430033	107430033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107430033G>A	ENST00000340010.5	-	6	855	c.671C>T	c.(670-672)tCc>tTc	p.S224F	SLC26A3_ENST00000422236.2_Missense_Mutation_p.S189F	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	224					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TTTGAGTTGGGAAACCAAAAC	0.393000													4	44					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40362803	40362803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40362803G>A	ENST00000221347.6	-	32	15274	c.15267C>T	c.(15265-15267)ttC>ttT	p.F5089F		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5089						extracellular region	protein binding	p.F5089F(1)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGCGGCACAGGAAGGCTTTGT	0.657000													52	132					0	0	1	0	0
CCL23	6368	broad.mit.edu	37	17	34340942	34340942	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34340942C>T	ENST00000293280.2	-	3	214	c.144G>A	c.(142-144)tgG>tgA	p.W48*	CCL23_ENST00000591423.1_Intron	NM_005064.3	NP_005055.2	P55773	CCL23_HUMAN	chemokine (C-C motif) ligand 23	46					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding			large_intestine(2)|liver(1)|lung(2)|prostate(1)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	TCTTTCTCCTCCAGAGCACTG	0.542000													13	18					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220337666	220337666	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220337666G>A	ENST00000312358.7	+	16	4127	c.3995G>A	c.(3994-3996)tGg>tAg	p.W1332*	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1332	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCGGACCAGTGGACGGCACTG	0.647000													20	49					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7950045	7950045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7950045G>A	ENST00000309838.2	-	1	164	c.165C>T	c.(163-165)ctC>ctT	p.L55L		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGGGAACGTGGAGGCTCTGGT	0.473000													40	117					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124207135	124207135	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124207135G>A	ENST00000360013.3	+	29	4490	c.4363G>A	c.(4363-4365)Gat>Aat	p.D1455N	KALRN_ENST00000240874.3_Missense_Mutation_p.D1455N|KALRN_ENST00000460856.1_Missense_Mutation_p.D1446N	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1455	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GAAAGCCAATGATGCCATGCA	0.522000													27	56					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16895700	16895700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16895700G>A	ENST00000430580.2	-	23	3369	c.2482C>T	c.(2482-2484)Ccc>Tcc	p.P828S	NBPF1_ENST00000287968.8_3'UTR|NBPF1_ENST00000432949.1_Intron|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	828	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GACTCCTGGGGGACTTCCTCC	0.478000													28	368					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125831637	125831637	+	Silent	SNP	G	G	A	rs139545472		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125831637G>A	ENST00000393434.2	-	19	2518	c.2169C>T	c.(2167-2169)ttC>ttT	p.F723F	ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000472186.1_Silent_p.F723F|ALDH1L1_ENST00000452905.2_Silent_p.F622F|ALDH1L1_ENST00000273450.3_Silent_p.F733F	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	723	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CTCTCCGCACGAACTCATCAT	0.572000													26	98					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96024216	96024216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96024216C>T	ENST00000297954.4	+	12	3187	c.3187C>T	c.(3187-3189)Cct>Tct	p.P1063S	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.P675S|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.P675S|WNK2_ENST00000395477.2_Missense_Mutation_p.P1063S			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1063					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						GCCTGCCGCCCCTGAGCTCCT	0.682000													6	23					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323870	44323870	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:44323870C>T	ENST00000354250.2	+	3	817	c.748C>T	c.(748-750)Ccc>Tcc	p.P250S	NDUFV3_ENST00000340344.3_Intron|NDUFV3_ENST00000460259.1_3'UTR	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	20					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	AACCACAATGCCCAGATCTCA	0.398000													20	179					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30891955	30891955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30891955C>T	ENST00000540456.1	-	3	233	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	SEC14L4_ENST00000392772.2_5'UTR|SEC14L4_ENST00000381982.3_Missense_Mutation_p.R45Q|SEC14L4_ENST00000255858.7_Missense_Mutation_p.R45Q			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	138						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	GTCAAAGTTTCGAGCTGCAAG	0.502000													5	21					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153430423	153430423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153430423G>A	ENST00000368723.3	-	3	275	c.165C>T	c.(163-165)ctC>ctT	p.L55L	S100A7_ENST00000368722.1_Silent_p.L55L	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	55	EF-hand 2.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGACATCGGCGAGGTAATTTG	0.418000													26	100					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25449508	25449508	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25449508C>T	ENST00000424208.1	+	0	2339				SNORD115-19_ENST00000363098.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						TGGGTTGGGTCGATGATGAGA	0.517000													55	245					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81702170	81702170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81702170C>T	ENST00000372292.3	-	4	447	c.407G>A	c.(406-408)gGc>gAc	p.G136D		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	136	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TCCTTTTGGGCCTGGCTTGCC	0.597000													19	39					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129278591	129278591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129278591C>T	ENST00000393239.1	-	32	5347	c.5169G>A	c.(5167-5169)aaG>aaA	p.K1723K	PLXND1_ENST00000324093.4_Silent_p.K1723K			Q9Y4D7	PLXD1_HUMAN	plexin D1	1723					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						TCAGAATGGCCTTGAACAGGT	0.612000													28	127					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170030620	170030620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170030620G>A	ENST00000263816.3	-	56	11108	c.10823C>T	c.(10822-10824)cCa>cTa	p.P3608L		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3608	LDL-receptor class A 28.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCAGGATTCTGGGATGCAACG	0.517000													20	43					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111195390	111195390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:111195390C>T	ENST00000262839.2	-	2	1177	c.259G>A	c.(259-261)Gag>Aag	p.E87K		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	87					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGCAGTAGCTCCATGATCTCC	0.537000													72	28					0	0	1	0	0
TSKU	25987	broad.mit.edu	37	11	76507492	76507492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76507492C>T	ENST00000527881.1	+	2	1858	c.832C>T	c.(832-834)Ctg>Ttg	p.L278L	TSKU_ENST00000333090.4_Silent_p.L278L			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	278						extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					GTTTTCAGGCCTGAGCTCCCT	0.672000													18	59					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16025627	16025627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16025627G>A	ENST00000326742.7	-	9	1195	c.1194C>T	c.(1192-1194)atC>atT	p.I398I	CYP4F11_ENST00000402119.3_Silent_p.I398I|CYP4F11_ENST00000248041.7_Silent_p.I398I			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	398					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						AACATCGGGAGATGACCGGGA	0.627000													21	126					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939636	12939636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12939636C>T	ENST00000235349.5	-	4	1236	c.1166G>A	c.(1165-1167)gGa>gAa	p.G389E		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	389										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GATGGGATTTCCACAGAAGCT	0.522000													94	286					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62542072	62542072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:62542072C>T	ENST00000430451.2	+	3	1153	c.956C>T	c.(955-957)tCc>tTc	p.S319F	SYT16_ENST00000446982.2_Missense_Mutation_p.S319F|RP11-355I22.5_ENST00000553990.1_lincRNA	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	319								p.S319C(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTTGAAGATTCCTATGCCACT	0.502000													38	130					0	0	1	0	0
TMEM74B	55321	broad.mit.edu	37	20	1161580	1161580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1161580C>T	ENST00000381894.3	-	2	1354	c.683G>A	c.(682-684)aGa>aAa	p.R228K		NM_018354.1	NP_060824.1	Q9NUR3	CT046_HUMAN	transmembrane protein 74B	228						integral to membrane	protein binding										ATTGAGCTGTCTCATGCGCAG	0.602000													37	74					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440176	40440176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40440176C>T	ENST00000319592.4	-	4	1444	c.735G>A	c.(733-735)gtG>gtA	p.V245V	RBM47_ENST00000381793.2_Silent_p.V245V|RBM47_ENST00000381795.6_Silent_p.V245V|RBM47_ENST00000295971.7_Silent_p.V245V|RBM47_ENST00000514014.1_Silent_p.V207V|RBM47_ENST00000515809.1_Intron			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	245						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						AGAGGATCTTCACGGTCTCCA	0.617000													43	104					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22272156	22272156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22272156G>A	ENST00000594947.1	+	4	1748	c.1604G>A	c.(1603-1605)aGa>aAa	p.R535K		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R535I(1)		haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTACATAAGAGAATTCATGCT	0.363000													23	37					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116889168	116889168	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116889168G>A	ENST00000355044.3	+	5	826	c.700G>A	c.(700-702)Gaa>Aaa	p.E234K	ATRNL1_ENST00000527407.1_Missense_Mutation_p.E234K|ATRNL1_ENST00000529665.1_3'UTR	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	234	EGF-like 2.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGTATATTGTGAATGTGATAA	0.383000													13	93					0	0	1	0	0
WSCD1	23302	broad.mit.edu	37	17	6023659	6023659	+	Missense_Mutation	SNP	C	C	T	rs148765035		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6023659C>T	ENST00000574946.1	+	9	1796	c.1406C>T	c.(1405-1407)tCg>tTg	p.S469L	WSCD1_ENST00000539421.1_Missense_Mutation_p.S469L|WSCD1_ENST00000317744.5_Missense_Mutation_p.S469L|WSCD1_ENST00000573634.1_Missense_Mutation_p.S353L|WSCD1_ENST00000574232.1_Missense_Mutation_p.S469L			Q658N2	WSCD1_HUMAN	WSC domain containing 1	469						integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						AGCTACGCCTCGTGGTGGTCC	0.672000													55	80					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48678421	48678421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48678421C>T	ENST00000352832.5	+	18	4104	c.3732C>T	c.(3730-3732)ctC>ctT	p.L1244L	CACNA1G_ENST00000514717.1_Silent_p.L1244L|CACNA1G_ENST00000515765.1_Silent_p.L1267L|CACNA1G_ENST00000510366.1_Silent_p.L1267L|CACNA1G_ENST00000512389.1_Silent_p.L1267L|CACNA1G_ENST00000513964.1_Silent_p.L1267L|CACNA1G_ENST00000513689.2_Silent_p.L1267L|CACNA1G_ENST00000507609.1_Silent_p.L1267L|CACNA1G_ENST00000505165.1_Silent_p.L1267L|CACNA1G_ENST00000507336.1_Silent_p.L1267L|CACNA1G_ENST00000507510.2_Silent_p.L1267L|CACNA1G_ENST00000442258.2_Silent_p.L1244L|CACNA1G_ENST00000514181.1_Silent_p.L1267L|CACNA1G_ENST00000429973.2_Silent_p.L1267L|CACNA1G_ENST00000514079.1_Silent_p.L1267L|CACNA1G_ENST00000515165.1_Silent_p.L1267L|CACNA1G_ENST00000510115.1_Silent_p.L1244L|CACNA1G_ENST00000503485.1_Silent_p.L1267L|CACNA1G_ENST00000358244.5_Silent_p.L1244L|CACNA1G_ENST00000502264.1_Silent_p.L1244L|CACNA1G_ENST00000416767.4_Silent_p.L1267L|CACNA1G_ENST00000359106.5_Silent_p.L1267L|CACNA1G_ENST00000354983.4_Silent_p.L1244L|CACNA1G_ENST00000507896.1_Silent_p.L1267L|CACNA1G_ENST00000515411.1_Silent_p.L1267L|CACNA1G_ENST00000360761.4_Silent_p.L1244L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1267					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGTTCCGCCTCCTGTGTCACC	0.627000													55	85					0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30133195	30133195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30133195G>A	ENST00000403394.1	-	2	402	c.303C>T	c.(301-303)atC>atT	p.I101I	MAPK3_ENST00000395202.1_Silent_p.I101I|MAPK3_ENST00000395200.1_Silent_p.I72I|MAPK3_ENST00000263025.4_Silent_p.I101I|MAPK3_ENST00000322266.5_Silent_p.I101I|MAPK3_ENST00000395199.3_Silent_p.I101I|MAPK3_ENST00000484663.1_5'UTR	NM_001040056.1	NP_001035145.1	P27361	MK03_HUMAN	mitogen-activated protein kinase 3	101	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	CTCGGATGCCGATGACATTCT	0.602000													14	16					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2959084	2959084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2959084C>T	ENST00000396946.4	-	18	2835	c.2432G>A	c.(2431-2433)aGg>aAg	p.R811K		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	811					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCACTCGTGCCTGTCCTGGTA	0.607000			Mis		DLBCL								27	48					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28654823	28654823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28654823C>T	ENST00000280904.6	-	12	2157	c.1714G>A	c.(1714-1716)Gat>Aat	p.D572N	DSC2_ENST00000251081.6_Missense_Mutation_p.D572N	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	572	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GGGCTGTTATCATTCACGTCT	0.408000													19	32					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18458484	18458484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:18458484G>A	ENST00000338745.6	-	3	2032	c.298C>T	c.(298-300)Ctg>Ttg	p.L100L	SATB1_ENST00000475083.1_5'UTR|SATB1_ENST00000417717.2_Silent_p.L100L|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Silent_p.L100L	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	100	PDZ-like dimerization domain.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						TTTCTCACCAGCACAAATTCT	0.428000													49	127					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33464952	33464952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33464952G>A	ENST00000379471.2	-	21	2791	c.2704C>T	c.(2704-2706)Cga>Tga	p.R902*	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000455041.2_Nonsense_Mutation_p.R850*			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	902					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AAAAGGAATCGAAGGAAGCCA	0.502000													23	59					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9321515	9321515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9321515G>A	ENST00000261336.2	-	17	2085	c.2057C>T	c.(2056-2058)tCa>tTa	p.S686L	PZP_ENST00000381997.2_Missense_Mutation_p.S555L	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						AGGGATGACTGAACACGACTT	0.368000													36	86					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64556357	64556357	+	Silent	SNP	C	C	T	rs111652000		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:64556357C>T	ENST00000357395.3	+	60	12035	c.891C>T	c.(889-891)atC>atT	p.I297I	ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000344113.4_Silent_p.I3912I|SYNE2_ENST00000554584.1_Silent_p.I3945I|SYNE2_ENST00000555002.1_Silent_p.I546I|SYNE2_ENST00000358025.3_Silent_p.I3912I|SYNE2_ENST00000394768.2_Silent_p.I297I			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3912					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCAAAACTATCCTATTATCAA	0.279000													27	57					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155719427	155719427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155719427C>T	ENST00000510397.1	+	3	795	c.616C>T	c.(616-618)Cca>Tca	p.P206S	RBM46_ENST00000281722.3_Missense_Mutation_p.P206S|RBM46_ENST00000514866.1_Missense_Mutation_p.P206S	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	206	RRM 2.						nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				GAAACTAATTCCAGGTAAACT	0.338000													14	55					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104032305	104032305	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104032305C>T	ENST00000374874.3	+	3	646	c.207C>T	c.(205-207)acC>acT	p.T69T	LPPR1_ENST00000395056.2_Silent_p.T69T	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		69						integral to membrane	catalytic activity										GCTTCATCACCCCTCTGGTGC	0.443000													8	51					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41012157	41012157	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41012157C>T	ENST00000352632.3	+	13	1766	c.1680C>T	c.(1678-1680)tcC>tcT	p.S560S	SPTBN4_ENST00000598249.1_Silent_p.S560S|SPTBN4_ENST00000595535.1_Silent_p.S560S|SPTBN4_ENST00000344104.3_Silent_p.S560S|SPTBN4_ENST00000338932.3_Silent_p.S560S			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	560					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGCTGCTGTCCCGGGAGTGTG	0.652000													30	74					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62740730	62740730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62740730C>T	ENST00000371153.4	-	3	424	c.46G>A	c.(46-48)Gag>Aag	p.E16K	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	16										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GGGTCTTTCTCTTCATCCCCC	0.453000													28	77					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180348073	180348073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:180348073G>A	ENST00000410066.1	-	6	1199	c.596C>T	c.(595-597)cCt>cTt	p.P199L	ZNF385B_ENST00000409692.1_Missense_Mutation_p.P97L|ZNF385B_ENST00000409343.1_Missense_Mutation_p.P123L|ZNF385B_ENST00000336917.5_Missense_Mutation_p.P97L|ZNF385B_ENST00000466398.1_5'UTR	NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	199						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GTCCTTGGAAGGAACCATTTT	0.458000													5	77					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63257495	63257495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:63257495G>A	ENST00000323865.3	-	1	285	c.52C>T	c.(52-54)Ccc>Tcc	p.P18S	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	18					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GTCTCAAAGGGAGCCGGTGGT	0.622000													21	67					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25023478	25023478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25023478C>T	ENST00000400382.1	+	12	1855	c.1100C>T	c.(1099-1101)tCc>tTc	p.S367F	GGT1_ENST00000400380.1_Missense_Mutation_p.S367F|GGT1_ENST00000404532.1_Missense_Mutation_p.S23F|GGT1_ENST00000466310.1_3'UTR|GGT1_ENST00000400383.1_Missense_Mutation_p.S367F|GGT1_ENST00000248923.4_Missense_Mutation_p.S367F|GGT1_ENST00000403838.1_Missense_Mutation_p.S23F|GGT1_ENST00000406383.2_Missense_Mutation_p.S367F|GGT1_ENST00000404920.1_Missense_Mutation_p.S23F|GGT1_ENST00000404223.1_Missense_Mutation_p.S23F|GGT1_ENST00000401885.1_Missense_Mutation_p.S23F			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	367					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	CACCCGATCTCCTACTACAAG	0.637000													5	46					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202072836	202072836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202072836C>T	ENST00000360132.3	+	7	1178	c.760C>T	c.(760-762)Cct>Tct	p.P254S	CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000313728.7_Intron|CASP10_ENST00000272879.5_Silent_p.G284G|CASP10_ENST00000286186.6_Silent_p.G284G|CASP10_ENST00000448480.1_Silent_p.G241G|CASP10_ENST00000346817.5_Silent_p.G241G	NM_001206524.1|NM_001230.4|NM_032976.3	NP_001193453.1|NP_001221.2|NP_116758.1	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	0					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						ACCACAGAGGCCTCTGTGTCA	0.433000													26	56					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21119923	21119923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21119923G>A	ENST00000269228.5	-	18	3201	c.2647C>T	c.(2647-2649)Ctg>Ttg	p.L883L	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Silent_p.L565L	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	883					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCCGCATGCAGGTACTGACTG	0.483000													22	73					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504230	70504230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70504230C>T	ENST00000310961.5	+	22	3042	c.2624C>T	c.(2623-2625)cCa>cTa	p.P875L	LRRC7_ENST00000035383.5_Missense_Mutation_p.P870L|LRRC7_ENST00000415775.2_Missense_Mutation_p.P154L			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	870						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						ACTACCAGCCCATTGCCTGAA	0.468000													51	112					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448284	155448284	+	Silent	SNP	G	G	A	rs148724344		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155448284G>A	ENST00000368346.3	-	3	5016	c.4377C>T	c.(4375-4377)ccC>ccT	p.P1459P	ASH1L_ENST00000392403.3_Silent_p.P1459P			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1459					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding	p.P1459P(1)		autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TGGAAAGGAGGGGAGTCCTGC	0.478000													31	95					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99013055	99013055	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99013055G>C	ENST00000393504.1	+	8	1839	c.1422G>C	c.(1420-1422)ctG>ctC	p.L474L	CNGA3_ENST00000436404.2_Silent_p.L456L|CNGA3_ENST00000272602.2_Silent_p.L474L|CNGA3_ENST00000409937.1_Silent_p.L478L	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	474					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						ACGTGCACCTGGACACGCTGA	0.577000													5	21					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155488849	155488849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155488849C>T	ENST00000302068.4	+	4	658	c.595C>T	c.(595-597)Cgt>Tgt	p.R199C	FGB_ENST00000502545.1_3'UTR|FGB_ENST00000509493.1_5'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	199					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding	p.R199C(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TCGTGTGCTTCGTTCAATCCT	0.393000													52	111					0	0	1	0	0
TBX1	6899	broad.mit.edu	37	22	19752564	19752564	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19752564C>T	ENST00000332710.4	+	6	897	c.768C>T	c.(766-768)gcC>gcT	p.A256A	TBX1_ENST00000359500.3_Silent_p.A256A|TBX1_ENST00000329705.7_Silent_p.A256A	NM_080647.1	NP_542378.1	O43435	TBX1_HUMAN	T-box 1	256					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|lung(3)|ovary(2)	8	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				AGAAATATGCCGAGGAGAACT	0.542000													39	102					0	0	1	0	0
POU5F1	5460	broad.mit.edu	37	6	31138004	31138004	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31138004T>A	ENST00000259915.8	-	1	466	c.394A>T	c.(394-396)Aac>Tac	p.N132Y	POU5F1_ENST00000441888.3_Intron	NM_002701.4	NP_002692.2	Q01860	PO5F1_HUMAN	POU class 5 homeobox 1	132					anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	breast(1)|large_intestine(2)|lung(3)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	13						TCCTCCGGGTTTTGCTCCAGC	0.652000			T	EWSR1	sarcoma								25	58					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145109788	145109788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145109788G>A	ENST00000426825.1	-	18	2519	c.2438C>T	c.(2437-2439)cCt>cTt	p.P813L	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	813							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CACGTCGCCAGGGTGGAGATC	0.677000													11	26					0	0	1	0	0
NEXN	91624	broad.mit.edu	37	1	78398979	78398979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:78398979G>A	ENST00000330010.8	+	9	1171	c.874G>A	c.(874-876)Gac>Aac	p.D292N	NEXN_ENST00000480732.1_3'UTR|NEXN_ENST00000334785.7_Missense_Mutation_p.D356N|NEXN_ENST00000457030.1_Missense_Mutation_p.D342N	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	356	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		AGTAGATGATGACTCCCCAGA	0.299000													4	35					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878191	150878191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150878191G>A	ENST00000422024.1	-	3	1199	c.1074C>T	c.(1072-1074)ctC>ctT	p.L358L	ASB10_ENST00000420175.2_Silent_p.L313L|ASB10_ENST00000377867.3_Silent_p.L298L|ASB10_ENST00000434669.1_Silent_p.L358L|ASB10_ENST00000275838.1_Silent_p.L313L	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	313					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACAGGACAGGAGCAGCTCCA	0.672000													4	30					0	0	1	0	0
CLSTN1	22883	broad.mit.edu	37	1	9795569	9795569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9795569G>A	ENST00000377298.4	-	13	2631	c.1839C>T	c.(1837-1839)ttC>ttT	p.F613F	CLSTN1_ENST00000361311.4_Silent_p.F603F|CLSTN1_ENST00000377288.3_Silent_p.F594F	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	613					homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		CGGGCGTGGGGAACTGCCGGG	0.507000													44	155					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41497234	41497234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41497234C>T	ENST00000324071.4	+	1	31	c.24C>T	c.(22-24)ttC>ttT	p.F8F		NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	8					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TCCTCCTCTTCCTTGCACTCC	0.622000													71	184					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173552676	173552676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173552676C>T	ENST00000367714.3	-	6	1031	c.609G>A	c.(607-609)cgG>cgA	p.R203R	RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Silent_p.R101R	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	203					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										TTCTGTTGCCCCGAAAATTTC	0.279000													28	79					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94158125	94158125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94158125C>T	ENST00000553484.1	+	48	7640	c.7486C>T	c.(7486-7488)Cac>Tac	p.H2496Y	UNC79_ENST00000555664.1_Missense_Mutation_p.H2435Y|UNC79_ENST00000256339.4_Missense_Mutation_p.H2297Y|UNC79_ENST00000393151.2_Missense_Mutation_p.H2474Y			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2474						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CTCCCTCTTCCACGCGTTCAT	0.532000													30	84					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7580705	7580705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7580705G>A	ENST00000379802.3	+	23	4623	c.4282G>A	c.(4282-4284)Gaa>Aaa	p.E1428K	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1428	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAGGGTGGAAGAAGACATCCA	0.488000													19	59					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645535	45645535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:45645535C>T	ENST00000303230.4	-	2	658	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	201						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GAACTGTCTTCATTGACAGTC	0.388000													27	77					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110764629	110764629	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:110764629A>G	ENST00000451085.1	+	4	2847	c.1801A>G	c.(1801-1803)Aaa>Gaa	p.K601E	IMMP2L_ENST00000489381.1_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.K601E|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000331762.3_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.K601E|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000447215.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	601	Fibronectin type-III.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		CATCTATCAGAAAAACAGAAA	0.348000													5	58					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55418468	55418468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55418468C>T	ENST00000312422.2	+	1	89	c.89C>T	c.(88-90)tCt>tTt	p.S30F		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GTGGTGTTTTCTTTCTTCTAC	0.388000													28	117					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849489	73849489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73849489C>T	ENST00000523207.1	+	3	2487	c.1899C>T	c.(1897-1899)ttC>ttT	p.F633F		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	633					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AGATGAAGTTCCCAACCGACC	0.607000													40	114					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143793109	143793109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143793109C>T	ENST00000408949.2	+	1	969	c.909C>T	c.(907-909)gtC>gtT	p.V303V		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					TAAAGAGAGTCCTTTGGAAAC	0.438000													55	172					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088044	86088044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:86088044G>A	ENST00000330753.4	+	2	953	c.186G>A	c.(184-186)ccG>ccA	p.P62P	FLRT2_ENST00000554746.1_Silent_p.P62P	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	62	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TTGGGATCCCGGAGGGCGTAA	0.517000													23	122					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6458118	6458118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6458118C>T	ENST00000396966.2	-	9	1512	c.1493G>A	c.(1492-1494)aGa>aAa	p.R498K	SCNN1A_ENST00000540037.1_Silent_p.K217K|SCNN1A_ENST00000360168.3_Silent_p.K576K|SCNN1A_ENST00000228916.2_Silent_p.K517K|SCNN1A_ENST00000543768.1_Silent_p.K540K|SCNN1A_ENST00000358945.3_Silent_p.K539K			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	498					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	GGACTGACCTCTTGTTGTTGA	0.488000													126	321					0	0	1	0	0
GFOD2	81577	broad.mit.edu	37	16	67709604	67709604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67709604G>A	ENST00000268797.7	-	3	957	c.612C>T	c.(610-612)ttC>ttT	p.F204F	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	204						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TCTGCCTCACGAATGTCTTGA	0.612000													7	72					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128452782	128452782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128452782G>A	ENST00000297788.4	+	14	2929	c.2562G>A	c.(2560-2562)gtG>gtA	p.V854V	CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000487361.1_Intron|CCDC136_ENST00000464832.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	854						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						AAATGGTTGTGAAAGTGCTGA	0.577000													16	34					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126412156	126412156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126412156G>A	ENST00000394329.3	+	17	14192	c.14179G>A	c.(14179-14181)Gat>Aat	p.D4727N	FAT4_ENST00000335110.5_Missense_Mutation_p.D2968N	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4727					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCCTATAAGGGATGGTAATAC	0.493000													35	91					0	0	1	0	0
ADPRH	141	broad.mit.edu	37	3	119305206	119305206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119305206C>T	ENST00000478399.1	+	3	1778	c.373C>T	c.(373-375)Cat>Tat	p.H125Y	ADPRH_ENST00000465513.1_Missense_Mutation_p.H125Y|ADPRH_ENST00000478927.1_Missense_Mutation_p.H125Y|ADPRH_ENST00000357003.3_Missense_Mutation_p.H125Y|ADPRH_ENST00000471850.1_3'UTR			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	125					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		CTTCAACAGCCATGAGGGCGG	0.607000													64	139					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169282328	169282328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169282328C>T	ENST00000511577.1	-	37	5210	c.4963G>A	c.(4963-4965)Gat>Aat	p.D1655N	DDX60L_ENST00000260184.7_Missense_Mutation_p.D1655N			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1655							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		AATGCAAAATCTTTCAAACAC	0.289000													5	18					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42780032	42780032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42780032C>T	ENST00000330714.3	+	14	2204	c.2020C>T	c.(2020-2022)Cgc>Tgc	p.R674C		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	674	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				GGAAAAAAATCGCTATTCCTG	0.468000													54	45					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197036305	197036305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197036305C>T	ENST00000367412.1	-	1	92	c.49G>A	c.(49-51)Gaa>Aaa	p.E17K		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	17					blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						GCATAGAGTTCTCCTGAGATT	0.284000													14	38					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226446683	226446683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:226446683G>A	ENST00000272907.6	+	4	963	c.550G>A	c.(550-552)Gat>Aat	p.D184N	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	184																	ACCCCACAGCGATGAATATTC	0.413000													17	213					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21992265	21992265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21992265C>T	ENST00000327430.3	-	2	1891	c.1597G>A	c.(1597-1599)Ggc>Agc	p.G533S	SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron|SALL2_ENST00000450879.2_Missense_Mutation_p.G396S	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	533							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		ATGGCTGAGCCCTCACTCCCT	0.517000													7	67					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118310689	118310689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118310689C>T	ENST00000369221.2	+	5	432	c.404C>T	c.(403-405)tCg>tTg	p.S135L	PNLIP_ENST00000470562.1_3'UTR	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	135					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	ACACAAGCCTCGCAGAACATC	0.463000													7	30					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200014584	200014584	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200014584G>A	ENST00000367362.3	+	4	581	c.335G>A	c.(334-336)cGa>cAa	p.R112Q	NR5A2_ENST00000236914.3_Missense_Mutation_p.R66Q|NR5A2_ENST00000544748.1_Missense_Mutation_p.R40Q	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	112					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					TTTTTTAAGCGAACAGTCCAA	0.323000													12	68					0	0	1	0	0
PDK2	5164	broad.mit.edu	37	17	48174904	48174904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48174904C>T	ENST00000503176.1	+	2	397	c.236C>T	c.(235-237)cCc>cTc	p.P79L	PDK2_ENST00000007708.3_Missense_Mutation_p.P15L	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	79					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						CTGAGCACACCCTCCGTGCAG	0.612000									Autosomal Dominant Polycystic Kidney Disease				9	37					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159514632	159514632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:159514632G>A	ENST00000307765.5	+	3	518	c.267G>A	c.(265-267)gaG>gaA	p.E89E	RXFP1_ENST00000343542.5_Silent_p.E89E|RXFP1_ENST00000470033.1_Intron|RXFP1_ENST00000460056.2_Silent_p.E8E|RXFP1_ENST00000423548.1_Silent_p.E89E|RXFP1_ENST00000448688.2_Silent_p.E8E	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	89						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		ATCCTTTTGAGGCAGAAACAC	0.313000													5	47					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70978497	70978497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70978497C>T	ENST00000276594.2	-	5	1357	c.1156G>A	c.(1156-1158)Ggg>Agg	p.G386R		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GGCTGCTTCCCCGGCTCTGTG	0.537000													8	73					0	0	1	0	0
CPNE6	9362	broad.mit.edu	37	14	24546362	24546362	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24546362G>A	ENST00000397016.2	+	16	1610		c.e16-1		CPNE6_ENST00000216775.2_Splice_Site|CPNE6_ENST00000537691.1_Splice_Site			O95741	CPNE6_HUMAN	copine VI (neuronal)						lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		CTTGCCCTCAGAAGTACTCGG	0.597000													11	47					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121957874	121957874	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121957874G>A	ENST00000379692.4	-	4	1778	c.1252C>T	c.(1252-1254)Ctc>Ttc	p.L418F		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	418										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						AGTCGAACGAGGTATTTAGCT	0.423000													66	160					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39452309	39452309	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39452309C>T	ENST00000280481.7	+	22	8926	c.8710C>T	c.(8710-8712)Cag>Tag	p.Q2904*		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2904					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGATCCTGTCCAGAATCTGGG	0.398000													36	135					0	0	1	0	0
PHOX2B	8929	broad.mit.edu	37	4	41750565	41750565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41750565C>T	ENST00000226382.2	-	1	422	c.63G>A	c.(61-63)atG>atA	p.M21I	RP11-227F19.1_ENST00000508038.1_RNA	NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	21					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						TCGAGGTGTCCATCCCAGCCA	0.498000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				12	31					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39777260	39777260	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39777260G>A	ENST00000540235.1	-	8	1394	c.1395C>T	c.(1393-1395)acC>acT	p.T465T	KRT17_ENST00000311208.8_Silent_p.T306T			P14923	PLAK_HUMAN	junction plakoglobin	0					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		AGGCCTGCATGGTGCGCCGGA	0.597000													21	28					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28659862	28659862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28659862C>T	ENST00000280904.6	-	11	2057	c.1614G>A	c.(1612-1614)gaG>gaA	p.E538E	DSC2_ENST00000251081.6_Silent_p.E538E	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	538	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTTTGATGGTCTCTGCCTCTC	0.388000													19	229					0	0	1	0	0
LRRC39	127495	broad.mit.edu	37	1	100620727	100620727	+	Missense_Mutation	SNP	C	C	T	rs142389687	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100620727C>T	ENST00000370138.1	-	8	890	c.692G>A	c.(691-693)cGa>cAa	p.R231Q	LRRC39_ENST00000342895.3_Missense_Mutation_p.R231Q|LRRC39_ENST00000370137.1_Missense_Mutation_p.R231Q	NM_001256385.1	NP_001243314.1	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39	231										endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	13		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		TATTTCATTTCGTTGCAGCCA	0.308000													9	68					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123842272	123842272	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123842272G>A	ENST00000369005.1	+	4	597	c.257G>A	c.(256-258)gGa>gAa	p.G86E	TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.G86E|TACC2_ENST00000334433.3_Missense_Mutation_p.G86E|TACC2_ENST00000515273.1_Missense_Mutation_p.G86E|TACC2_ENST00000453444.2_Missense_Mutation_p.G86E	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	86						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GACCCACAGGGAGCCAGGGGG	0.637000													30	88					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226446723	226446723	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:226446723G>A	ENST00000272907.6	+	4	1003	c.590G>A	c.(589-591)cGa>cAa	p.R197Q	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	197								p.R197Q(2)									AAACCGAAGCGAAATCCGAAC	0.502000													71	196					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135441522	135441522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135441522G>A	ENST00000394143.1	+	11	7343	c.7052G>A	c.(7051-7053)aGt>aAt	p.S2351N	GPR112_ENST00000370652.1_Missense_Mutation_p.S2351N|GPR112_ENST00000394141.1_Missense_Mutation_p.S2146N|GPR112_ENST00000412101.1_Missense_Mutation_p.S2146N|GPR112_ENST00000287534.4_Intron	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2351					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AAAATCAAAAGTAAAATACAT	0.338000													73	41					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115454199	115454199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115454199G>A	ENST00000369522.3	+	18	1765	c.1525G>A	c.(1525-1527)Gag>Aag	p.E509K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E509K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	509				IQLTAITTSEQYYSKEVKDLKTELENEK -> YSYCHYHKW TVLPKRGQRPKLSSKRE (in Ref. 2; BAA22586).	cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTTGAAAACGAGAAGTATGT	0.249000													12	29					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1914014	1914014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1914014G>A	ENST00000399161.2	-	13	2562	c.1815C>T	c.(1813-1815)ctC>ctT	p.L605L	MYT1L_ENST00000428368.2_Silent_p.L603L	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	605					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGGGTACCTGAGCACGCGGT	0.637000													26	27					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45681059	45681059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45681059G>A	ENST00000270172.3	-	2	567	c.84C>T	c.(82-84)tcC>tcT	p.S28S	DNMT3L_ENST00000418993.1_Silent_p.S28S	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	28					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		CGGGTGAAACGGAGCTTGAGA	0.602000													36	83					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101566311	101566311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101566311G>A	ENST00000284395.5	+	18	2765	c.2365G>A	c.(2365-2367)Ggc>Agc	p.G789S	LRRK1_ENST00000388948.3_Missense_Mutation_p.G792S			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	792	Roc.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAGGGCCACAGGCTTCCCAGA	0.582000													12	64					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73615104	73615104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73615104C>T	ENST00000261917.3	-	8	4323	c.3330G>A	c.(3328-3330)ggG>ggA	p.G1110G		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	1110					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		CCATGGACTCCCCTGAGGAGT	0.721000													4	4					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99800311	99800311	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:99800311G>A	ENST00000259470.5	-	2	264	c.15C>T	c.(13-15)ctC>ctT	p.L5L	CTSV_ENST00000479932.1_5'UTR|CTSV_ENST00000538255.1_Silent_p.L5L	NM_001333.3	NP_001324.2			cathepsin V																		CAGCCAGGACGAGCGAAAGAT	0.418000													24	68					0	0	1	0	0
FAM217B	63939	broad.mit.edu	37	20	58519433	58519433	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58519433C>T	ENST00000358293.3	+	5	850	c.435C>T	c.(433-435)ttC>ttT	p.F145F	FAM217B_ENST00000469084.1_Intron|FAM217B_ENST00000360816.3_Silent_p.F145F	NM_001190826.1	NP_001177755.1	Q9NTX9	CT177_HUMAN	family with sequence similarity 217, member B	145																	ATCCTAATTTCCTTCCATCCC	0.483000													8	101					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57422542	57422542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57422542C>T	ENST00000543257.1	-	4	701	c.135G>A	c.(133-135)ggG>ggA	p.G45G	C8B_ENST00000371237.4_Silent_p.G97G|C8B_ENST00000535057.1_Silent_p.G35G	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	97					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGCACGGTTCCCCATGGAACT	0.522000													42	167					0	0	1	0	0
TBC1D21	161514	broad.mit.edu	37	15	74174023	74174023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74174023C>T	ENST00000300504.2	+	3	290	c.207C>T	c.(205-207)ttC>ttT	p.F69F	TBC1D21_ENST00000562056.1_Silent_p.F69F|TBC1D21_ENST00000535547.2_Silent_p.F33F	NM_153356.1	NP_699187.1	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	69	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	17						CCTGGAAATTCCTCACGGGCT	0.597000													13	48					0	0	1	0	0
CA9	768	broad.mit.edu	37	9	35675537	35675537	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35675537G>A	ENST00000378357.4	+	2	510	c.406G>A	c.(406-408)Gat>Aat	p.D136N		NM_001216.2	NP_001207.2	Q16790	CAH9_HUMAN	carbonic anhydrase IX	136	Catalytic.				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	17	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TTATACAGGGGATGACCAGAG	0.547000													10	47					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2610032	2610032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2610032C>T	ENST00000155840.5	+	10	1449	c.1341C>T	c.(1339-1341)ccC>ccT	p.P447P	KCNQ1_ENST00000335475.5_Silent_p.P320P	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	447					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CGTGCGACCCCCCAGAAGAGC	0.552000													9	31					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870051	4870051	+	Missense_Mutation	SNP	G	G	A	rs139421041		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4870051G>A	ENST00000322101.2	-	1	463	c.388C>T	c.(388-390)Cgg>Tgg	p.R130W	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R130W(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCAGTGCCCGATCAATGGAC	0.522000													45	99					0	0	1	0	0
STYXL1	51657	broad.mit.edu	37	7	75634657	75634657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:75634657G>A	ENST00000451157.1	-	6	688	c.519C>T	c.(517-519)ttC>ttT	p.F173F	STYXL1_ENST00000359697.3_Silent_p.F173F|STYXL1_ENST00000248600.1_Silent_p.F173F|STYXL1_ENST00000360591.3_3'UTR|STYXL1_ENST00000431581.1_Silent_p.F173F|STYXL1_ENST00000340062.5_Silent_p.F77F			Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	173	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						AGGCTTGACTGAAATTGCCAA	0.468000													33	87					0	0	1	0	0
MYL10	93408	broad.mit.edu	37	7	101265448	101265448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101265448C>T	ENST00000223167.4	-	5	559	c.382G>A	c.(382-384)Gcc>Acc	p.A128T		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	128						mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						TTCACCATGGCCTCCAGTTCC	0.602000													10	54					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104057386	104057386	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104057386G>T	ENST00000265148.3	-	40	6523	c.6434C>A	c.(6433-6435)cCc>cAc	p.P2145H	CENPE_ENST00000380026.3_Missense_Mutation_p.P2024H	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2145	Kinetochore-binding domain.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTGTAAATAGGGAAGTGAGAG	0.358000													47	105					1.06522e-23	1.07205e-23	1	1	0
ELF3	1999	broad.mit.edu	37	1	201983066	201983066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201983066C>T	ENST00000359651.3	+	7	4107	c.915C>T	c.(913-915)ttC>ttT	p.F305F	ELF3_ENST00000367284.5_Silent_p.F305F|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Silent_p.F305F			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	305					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.L306fs*19(2)		breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						TCTTCAAGTTCCTGCGCTCCG	0.592000													5	27					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40113039	40113039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40113039G>A	ENST00000373233.3	-	15	2387	c.2210C>T	c.(2209-2211)aCc>aTc	p.T737I	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	737					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CTCCATCATGGTGTTGATGAG	0.493000													58	163					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65456139	65456139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:65456139C>T	ENST00000330909.8	-	5	777	c.778G>A	c.(778-780)Gag>Aag	p.E260K	MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000402939.2_Missense_Mutation_p.E260K|MAGI1_ENST00000483466.1_Missense_Mutation_p.E260K|MAGI1_ENST00000497477.2_Missense_Mutation_p.E260K	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	260	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		AGAGTGTGCTCCTCTTGTTCA	0.458000													14	81					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128987836	128987836	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:128987836C>T	ENST00000314797.6	+	18	1940	c.1836C>T	c.(1834-1836)atC>atT	p.I612I		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	612	Interaction with ZNF289/ARFGAP2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										GGCAGGAGATCTTCCAGGGTG	0.512000													24	85					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36330297	36330297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36330297C>T	ENST00000378910.5	-	22	2950	c.2951G>A	c.(2950-2952)gGg>gAg	p.G984E	NPHS1_ENST00000353632.6_Missense_Mutation_p.G984E	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	984	Fibronectin type-III.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATAGTGGAACCCTGGAGTCCC	0.577000													19	62					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169509663	169509663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169509663C>T	ENST00000367796.3	-	13	4881	c.4680G>A	c.(4678-4680)agG>agA	p.R1560R	F5_ENST00000367797.3_Silent_p.R1555R			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1555	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGATGTTTGTCCTAACATCAG	0.418000													29	47					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11102947	11102947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11102947G>A	ENST00000400897.3	-	6	889	c.874C>T	c.(874-876)Cac>Tac	p.H292Y		NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2	292	CUB 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CTCGTGTAGTGGATCTTCCAG	0.532000													42	92					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88584064	88584064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88584064G>A	ENST00000339673.6	+	6	1233	c.1134G>A	c.(1132-1134)caG>caA	p.Q378Q	RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Silent_p.Q362Q|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	378					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		TAGAAGACCAGGAAGACAGTG	0.532000													50	167					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559623	44559623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44559623C>T	ENST00000332567.4	-	1	2365	c.2013G>A	c.(2011-2013)gaG>gaA	p.E671E	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	671					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CTGGCTTGATCTCCCCATTTT	0.582000													35	96					0	0	1	0	0
TM7SF3	51768	broad.mit.edu	37	12	27143469	27143469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:27143469G>A	ENST00000343028.4	-	6	1007	c.782C>T	c.(781-783)cCg>cTg	p.P261L	TM7SF3_ENST00000542667.1_Intron	NM_016551.2	NP_057635.1	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3	261						integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	18	Colorectal(261;0.0847)					ATTTAGAAACGGGTCCCAAAC	0.483000													25	92					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132307179	132307179	+	Missense_Mutation	SNP	C	C	T	rs148167692		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:132307179C>T	ENST00000331898.7	-	4	1179	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K	OPCML_ENST00000374778.4_Missense_Mutation_p.E160K|OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000524381.1_Missense_Mutation_p.E194K|OPCML_ENST00000541867.1_Missense_Mutation_p.E201K	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	201	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity	p.E201K(2)|p.E201Q(1)|p.E194Q(1)		endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GCGCTGCATTCGTACTCCCCG	0.532000													11	63					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765989	77765989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77765989C>T	ENST00000521891.2	+	10	7280	c.6832C>T	c.(6832-6834)Cgt>Tgt	p.R2278C	ZFHX4_ENST00000455469.2_Missense_Mutation_p.R2233C|ZFHX4_ENST00000050961.6_Missense_Mutation_p.R2233C|ZFHX4_ENST00000518282.1_Missense_Mutation_p.R2252C	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2233						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAGAATGCTCGTCAGAAAGC	0.388000										HNSCC(33;0.089)			7	27					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157740417	157740417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157740417C>T	ENST00000361516.3	-	3	140	c.92G>A	c.(91-93)gGa>gAa	p.G31E	FCRL2_ENST00000368181.4_Missense_Mutation_p.G31E|FCRL2_ENST00000392274.3_Missense_Mutation_p.G31E	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	31	Ig-like C2-type 1.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GATGCTGTCTCCTTCGAAGAC	0.453000													6	52					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35617264	35617264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35617264G>A	ENST00000392225.3	-	7	1805	c.1286C>T	c.(1285-1287)tCc>tTc	p.S429F	LGI4_ENST00000493050.1_5'UTR|LGI4_ENST00000310123.3_Silent_p.I403I			Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	0						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CGGCCTCGGGGATGTCTGTGC	0.667000													5	12					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192545481	192545481	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:192545481C>T	ENST00000367459.3	+	2	270	c.204C>T	c.(202-204)tcC>tcT	p.S68S	RGS1_ENST00000469578.2_Silent_p.S68S	NM_002922.3	NP_002913.3	Q08116	RGS1_HUMAN	regulator of G-protein signaling 1	68					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			kidney(8)|large_intestine(1)|lung(13)	22		Breast(1374;0.188)				TGAAATCTTCCAAGTCCAAGG	0.343000													19	50					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701424	56701424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56701424G>A	ENST00000586855.2	-	5	1573	c.1260C>T	c.(1258-1260)ttC>ttT	p.F420F	ZSCAN5B_ENST00000358992.3_Silent_p.F420F			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	420					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ACTCGTGGGCGAACCGCTTTT	0.567000													20	55					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7260984	7260984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7260984G>A	ENST00000266542.4	-	2	255	c.163C>T	c.(163-165)Ccc>Tcc	p.P55S	C1RL_ENST00000545280.1_Intron|C1RL_ENST00000545337.1_Missense_Mutation_p.P55S|C1RL_ENST00000544702.1_Missense_Mutation_p.P55S|C1RL-AS1_ENST00000435921.2_RNA|C1RL-AS1_ENST00000541775.1_RNA	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	55	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGGTACCCGGGGGATGTCAGC	0.622000													22	50					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858544	9858544	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9858544C>G	ENST00000396573.2	-	14	3166	c.2857G>C	c.(2857-2859)Gag>Cag	p.E953Q	GRIN2A_ENST00000535259.1_Missense_Mutation_p.E796Q|GRIN2A_ENST00000404927.2_Missense_Mutation_p.E953Q|GRIN2A_ENST00000562109.1_Missense_Mutation_p.E953Q|GRIN2A_ENST00000330684.3_Missense_Mutation_p.E953Q|GRIN2A_ENST00000396575.2_Missense_Mutation_p.E953Q	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	953					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAAATGCTCTCTTTCCCCTGA	0.443000													14	164					0	0	1	0	0
TUT1	64852	broad.mit.edu	37	11	62359062	62359062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62359062G>A	ENST00000308436.7	-	1	47	c.10C>T	c.(10-12)Cct>Tct	p.P4S	TUT1_ENST00000476907.1_5'UTR	NM_022830.2	NP_073741.2	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6 snRNA-specific	0					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GATCCGATAGGAAGTGACATA	0.572000													4	7					0	0	1	0	0
RNF220	55182	broad.mit.edu	37	1	45079881	45079881	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:45079881T>C	ENST00000355387.2	+	3	1120	c.670T>C	c.(670-672)Tgc>Cgc	p.C224R	RNF220_ENST00000361799.2_Missense_Mutation_p.C224R|RNF220_ENST00000372247.2_Missense_Mutation_p.C224R|RNF220_ENST00000443020.2_5'UTR			Q5VTB9	RN220_HUMAN	ring finger protein 220	224					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						GGCCCCAATTTGCCCCATCTG	0.587000													33	94					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531165	92531165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92531165C>T	ENST00000298047.6	+	9	5003	c.4986C>T	c.(4984-4986)acC>acT	p.T1662T	FAT3_ENST00000525166.1_Silent_p.T1512T|FAT3_ENST00000409404.2_Silent_p.T1662T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1662	Cadherin 15.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTCCGTCACCATGTCTGACA	0.448000										TCGA Ovarian(4;0.039)			33	58					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36872640	36872640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36872640C>T	ENST00000301807.6	-	21	8549	c.6652G>A	c.(6652-6654)Gag>Aag	p.E2218K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E2768K|TRANK1_ENST00000428977.2_Missense_Mutation_p.E2218K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2768					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CTGTTCCTCTCCTGACACTCC	0.537000													44	84					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123971151	123971151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123971151C>T	ENST00000369005.1	+	9	7551	c.7211C>T	c.(7210-7212)gCt>gTt	p.A2404V	TACC2_ENST00000368999.1_Missense_Mutation_p.A482V|TACC2_ENST00000369004.3_Missense_Mutation_p.A482V|TACC2_ENST00000513429.1_Missense_Mutation_p.A550V|TACC2_ENST00000358010.1_Missense_Mutation_p.A550V|TACC2_ENST00000369000.1_Missense_Mutation_p.A108V|TACC2_ENST00000515603.1_Missense_Mutation_p.A2359V|TACC2_ENST00000369001.1_Missense_Mutation_p.A108V|TACC2_ENST00000334433.3_Missense_Mutation_p.A2404V|TACC2_ENST00000360561.3_Missense_Mutation_p.A482V|TACC2_ENST00000515273.1_Missense_Mutation_p.A2408V|TACC2_ENST00000453444.2_Missense_Mutation_p.A2408V|TACC2_ENST00000260733.3_Missense_Mutation_p.A482V	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2404						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCAGCCAGTGCTATGGAAGCC	0.542000													25	94					0	0	1	0	0
SEC61A1	29927	broad.mit.edu	37	3	127783766	127783766	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127783766C>T	ENST00000243253.3	+	8	847	c.663C>T	c.(661-663)gcC>gcT	p.A221A	SEC61A1_ENST00000483956.1_3'UTR|SEC61A1_ENST00000464451.1_Silent_p.A227A|SEC61A1_ENST00000424880.2_Silent_p.A101A|RUVBL1_ENST00000464873.1_3'UTR	NM_013336.3	NP_037468.1	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit (S. cerevisiae)	221					protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|prostate(4)	21						ATCTGCTGGCCACACGCACAG	0.507000													23	102					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683765	159683765	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159683765C>T	ENST00000255030.5	-	2	328	c.225G>A	c.(223-225)aaG>aaA	p.K75K	CRP_ENST00000368110.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000437342.1_Intron|CRP_ENST00000368111.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	75	Pentaxin.			YSIFSYATKRQDNEIL -> TVFSRMPPRDKTMRFF (in Ref. 4; CAA39671).	acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	TGTCTTGTCTCTTGGTGGCAT	0.453000													24	84					0	0	1	0	0
SS18	6760	broad.mit.edu	37	18	23615043	23615043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:23615043G>A	ENST00000415083.2	-	9	1077	c.1022C>T	c.(1021-1023)cCa>cTa	p.P341L	SS18_ENST00000545952.1_Missense_Mutation_p.P258L|SS18_ENST00000542743.1_Missense_Mutation_p.P258L|SS18_ENST00000542420.2_Missense_Mutation_p.P318L|SS18_ENST00000269137.7_Missense_Mutation_p.P310L|SS18_ENST00000539849.1_Missense_Mutation_p.P259L	NM_001007559.1|NM_005637.2	NP_001007560.1|NP_005628.2	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	341	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX2(706)|SS18/SSX1(1169)|SS18/SSX4(12)	endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(1)	19	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					TCCCTGTTGTGGAGGTGGTCC	0.473000			T	"""SSX1,  SSX2"""	synovial sarcoma								13	104					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210857425	210857425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210857425C>T	ENST00000367007.4	-	11	2256	c.2087G>A	c.(2086-2088)cGa>cAa	p.R696Q	KCNH1_ENST00000271751.4_Missense_Mutation_p.R723Q	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	723	Calmodulin-binding.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity	p.R723Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTCATTCTTTCGTTTCATGCG	0.552000													16	55					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55139748	55139748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55139748C>T	ENST00000257290.5	+	10	1740	c.1409C>T	c.(1408-1410)tCa>tTa	p.S470L	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	470	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AACAATGTCTCAAACATCATC	0.502000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			23	87					0	0	1	0	0
PROK1	84432	broad.mit.edu	37	1	110998924	110998924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110998924C>T	ENST00000271331.3	+	3	286	c.269C>T	c.(268-270)cCg>cTg	p.P90L		NM_032414.2	NP_115790.1	P58294	PROK1_HUMAN	prokineticin 1	90					angiogenesis|positive regulation of cell division	extracellular region	growth factor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|skin(1)|stomach(1)	9		all_cancers(81;6.23e-06)|all_epithelial(167;2.12e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0239)|all cancers(265;0.0699)|Epithelial(280;0.0753)|Colorectal(144;0.105)|LUSC - Lung squamous cell carcinoma(189;0.135)		TCCAGGTTCCCGGACGGCAGG	0.542000													30	69					0	0	1	0	0
GSTM5	2949	broad.mit.edu	37	1	110256060	110256060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110256060G>A	ENST00000369813.1	+	2	914	c.9G>A	c.(7-9)ggG>ggA	p.G3G	GSTM5_ENST00000369812.5_Silent_p.G63G|GSTM5_ENST00000256593.3_Intron			P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	0	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			NS(1)|central_nervous_system(6)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	21		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	GGATGCTGGGGAGCCTGGTGG	0.557000													32	96					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78647165	78647165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:78647165G>A	ENST00000286627.5	-	27	4348	c.3396C>T	c.(3394-3396)tcC>tcT	p.S1132S	KCNMA1_ENST00000372440.1_Silent_p.S1132S|KCNMA1_ENST00000354353.5_Silent_p.S1193S|KCNMA1_ENST00000404857.1_Silent_p.S1173S|KCNMA1_ENST00000406533.3_Silent_p.S1194S|KCNMA1_ENST00000286628.8_Silent_p.S1190S|KCNMA1_ENST00000404771.3_Silent_p.S1190S|KCNMA1_ENST00000372443.1_Silent_p.S1159S	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	1190					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GGGAGGAATGGGACAGGCTGG	0.587000													22	59					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	98996696	98996696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98996696G>A	ENST00000393504.1	+	4	691	c.274G>A	c.(274-276)Gac>Aac	p.D92N	CNGA3_ENST00000436404.2_Missense_Mutation_p.D92N|CNGA3_ENST00000272602.2_Missense_Mutation_p.D92N|CNGA3_ENST00000409937.1_Missense_Mutation_p.D96N	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	92					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						GCACCACCAGGACCAGGGACC	0.592000													32	96					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11951662	11951662	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:11951662C>T	ENST00000339865.5	+	12	2149	c.1386C>T	c.(1384-1386)ttC>ttT	p.F462F	USP47_ENST00000539466.1_5'UTR|USP47_ENST00000399455.2_Silent_p.F550F|USP47_ENST00000527733.1_Silent_p.F530F	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	550					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		CTAGTGCTTTCGCAAGGTAAG	0.318000													12	70					0	0	1	0	0
TMEM213	155006	broad.mit.edu	37	7	138487709	138487709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138487709C>T	ENST00000442682.2	+	3	372	c.219C>T	c.(217-219)atC>atT	p.I73I	TMEM213_ENST00000422794.2_Silent_p.I123I|TMEM213_ENST00000458494.1_Silent_p.I49I|TMEM213_ENST00000413208.1_Intron|TMEM213_ENST00000397602.3_Silent_p.I72I	NM_001085429.1	NP_001078898.1	A2RRL7	TM213_HUMAN	transmembrane protein 213	73						integral to membrane		p.I73I(2)		breast(1)|endometrium(3)|kidney(1)|lung(1)	6						ACGGCTGGATCGCGGCAGCTG	0.607000													9	34					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500527	90500527	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90500527G>A	ENST00000325643.5	+	4	1191	c.1125G>A	c.(1123-1125)atG>atA	p.M375I		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GAGCACTGATGAAGATGTGGC	0.562000													40	55					0	0	1	0	0
FA2H	79152	broad.mit.edu	37	16	74750319	74750319	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:74750319G>A	ENST00000219368.3	-	6	1034	c.965C>T	c.(964-966)tCg>tTg	p.S322L	FA2H_ENST00000544337.1_Missense_Mutation_p.S109L	NM_024306.4	NP_077282.3	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	322					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						CTTGTGCGGCGAGCCAAAGTG	0.602000													23	33					0	0	1	0	0
TMEM63A	9725	broad.mit.edu	37	1	226065251	226065251	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226065251C>A	ENST00000366835.3	-	3	300	c.30G>T	c.(28-30)tgG>tgT	p.W10C		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	10						integral to membrane|lysosomal membrane	nucleotide binding			breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					CCTTGGACTGCCACAGCTCCA	0.592000											OREG0014291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	40					6.42651e-13	6.45749e-13	1	1	0
PPP6R2	9701	broad.mit.edu	37	22	50875489	50875489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50875489C>T	ENST00000216061.5	+	16	2045	c.1675C>T	c.(1675-1677)Ctt>Ttt	p.L559F	PPP6R2_ENST00000395741.3_Intron|PPP6R2_ENST00000395744.3_Intron|PPP6R2_ENST00000359139.3_Intron			O75170	PP6R2_HUMAN	protein phosphatase 6, regulatory subunit 2	559						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						CGAGCTGTCCCTTCAGCAGGT	0.627000													4	4					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101865230	101865230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101865230G>A	ENST00000348070.1	-	18	2198	c.2199C>T	c.(2197-2199)ccC>ccT	p.P733P	PCSK6_ENST00000358417.3_Silent_p.P720P|PCSK6_ENST00000561177.1_5'UTR	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	734	CRM (Cys-rich motif).				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGTAGCCCAAGGGGCACACAC	0.637000													5	38					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17559460	17559460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17559460C>T	ENST00000375471.4	+	11	1400	c.1308C>T	c.(1306-1308)ttC>ttT	p.F436F		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	436					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	GGAGCAGCTTCCCCAAGTGAG	0.657000													9	11					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35541110	35541110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:35541110G>A	ENST00000287272.2	+	5	636	c.616G>A	c.(616-618)Gag>Aag	p.E206K	UNC5D_ENST00000416672.1_Missense_Mutation_p.E206K|UNC5D_ENST00000420357.1_Missense_Mutation_p.E206K|UNC5D_ENST00000404895.2_Missense_Mutation_p.E206K|UNC5D_ENST00000453357.2_Missense_Mutation_p.E201K			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	206	Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGAACAAGACGAGAACATTGA	0.458000													10	55					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61611571	61611571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61611571C>T	ENST00000583023.1	+	5	1011	c.1000C>T	c.(1000-1002)Ccc>Tcc	p.P334S	KCNH6_ENST00000581784.1_Missense_Mutation_p.P334S|KCNH6_ENST00000456941.2_Missense_Mutation_p.P334S|KCNH6_ENST00000580652.1_Missense_Mutation_p.P334S|KCNH6_ENST00000314672.5_Missense_Mutation_p.P334S	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	334					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GGTCAGCCACCCCCGCCGCAT	0.567000													32	56					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849634	98849634	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:98849634C>T	ENST00000554295.1	-	0	1289					NR_033801.1																						GCGCCAGGATCATGCAGGAGA	0.478000													14	70					0	0	1	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125231419	125231419	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:125231419G>A	ENST00000439075.1	-	0	3326					NR_026876.1																						AATTTGTTATGAAATTGGAGC	0.308000													6	12					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96106999	96106999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:96106999C>T	ENST00000343702.4	-	4	1430	c.982G>A	c.(982-984)Gag>Aag	p.E328K	NTN4_ENST00000344911.4_Missense_Mutation_p.E291K|NTN4_ENST00000553059.1_Missense_Mutation_p.E328K|NTN4_ENST00000538383.1_Missense_Mutation_p.E291K	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	328	Laminin EGF-like 1.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						CTTCTGCACTCGTTGGGAGCC	0.502000													20	65					0	0	1	0	0
TRAV5	28688	broad.mit.edu	37	14	22217766	22217766	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22217766C>T	ENST00000390427.3	+	0	129																											GAGACAGCTCCGTTATAAACT	0.463000													11	35					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42045550	42045550	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42045550G>A	ENST00000372584.1	-	3	5933	c.4919C>T	c.(4918-4920)cCg>cTg	p.P1640L	HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1640L|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1640L|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1640L|HIVEP3_ENST00000460604.1_5'UTR	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1640					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGAAACCCCCGGAAGGTTGGG	0.488000													38	62					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170610362	170610362	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:170610362C>T	ENST00000523189.1	+	18	2130	c.1966C>T	c.(1966-1968)Cat>Tat	p.H656Y	RANBP17_ENST00000521759.1_3'UTR	NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	656					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGTGACAATCATAGTCTCAG	0.388000			T	TRD@	ALL								31	70					0	0	1	0	0
HLA-DPB1	3115	broad.mit.edu	37	6	33052914	33052914	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33052914C>T	ENST00000418931.2	+	3	668	c.552C>T	c.(550-552)atC>atT	p.I184I		NM_002121.5	NP_002112.3	P04440	DPB1_HUMAN	major histocompatibility complex, class II, DP beta 1	184	Beta-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex				cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	11						CCTTCCAGATCCTGGTGATGC	0.562000													38	104					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78369177	78369177	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78369177C>T	ENST00000278550.7	-	34	8698	c.8236G>A	c.(8236-8238)Gag>Aag	p.E2746K		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4									p.E2746*(2)									GGGTACTGCTCGACAGAGATC	0.597000													85	210					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111216202	111216202	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111216202G>A	ENST00000369769.2	-	1	1453	c.1230C>T	c.(1228-1230)atC>atT	p.I410I		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	410						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGAGAAAAGGATGACCCCAA	0.577000													18	59					0	0	1	0	0
TOP1	7150	broad.mit.edu	37	20	39729862	39729862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39729862C>T	ENST00000361337.2	+	13	1427	c.1177C>T	c.(1177-1179)Cct>Tct	p.P393S	RP1-1J6.2_ENST00000454626.1_RNA	NM_003286.2	NP_003277.1	P11387	TOP1_HUMAN	topoisomerase (DNA) I	393					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	TGCCAAGGTTCCTTCTCCTCC	0.443000			T	NUP98	AML*								50	72					0	0	1	0	0
TMEM98	26022	broad.mit.edu	37	17	31261321	31261321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:31261321C>T	ENST00000579849.1	+	5	707	c.276C>T	c.(274-276)tcC>tcT	p.S92S	TMEM98_ENST00000578289.1_Silent_p.S92S|TMEM98_ENST00000394642.3_Silent_p.S92S	NM_015544.2	NP_056359.2	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	92						endoplasmic reticulum|integral to membrane				kidney(2)|large_intestine(1)	3		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			GTCTCATGTCCCACTGCATTG	0.537000													7	56					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78458888	78458888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:78458888C>T	ENST00000566780.1	+	7	1093	c.727C>T	c.(727-729)Ctc>Ttc	p.L243F	WWOX_ENST00000402655.2_Intron|WWOX_ENST00000406884.2_Intron|WWOX_ENST00000408984.3_Missense_Mutation_p.L243F|WWOX_ENST00000539474.2_Intron	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	243	Interaction with MAPT (By similarity).|Mediates targeting to the mitochondria (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TGTCCAGCTCCTCCAGGATGT	0.517000													53	159					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18332967	18332967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18332967G>A	ENST00000355502.3	-	6	1280	c.409C>T	c.(409-411)Cgg>Tgg	p.R137W	PDE4C_ENST00000594465.2_Missense_Mutation_p.R137W|PDE4C_ENST00000262805.11_Missense_Mutation_p.R105W|PDE4C_ENST00000447275.2_Missense_Mutation_p.R31W|PDE4C_ENST00000594617.2_Missense_Mutation_p.R137W			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	137					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GAGGAGTTCCGAGACATGGCC	0.607000													23	30					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368095	18368095	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18368095G>A	ENST00000392413.3	-	4	4214	c.3999C>T	c.(3997-3999)acC>acT	p.T1333T	KIAA1683_ENST00000600328.2_Silent_p.T1146T|KIAA1683_ENST00000600359.2_Silent_p.T1100T	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	136						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GGCCTCGCCAGGTGGCTTGAA	0.612000													4	59					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824044	54824044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:54824044G>A	ENST00000243911.2	+	1	257	c.145G>A	c.(145-147)Ggc>Agc	p.G49S		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	86					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding	p.G86R(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			CCTGTCTCTGGGCATCGTCAG	0.567000													23	137					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47361637	47361637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47361637G>A	ENST00000396220.1	-	3	361	c.339C>T	c.(337-339)ttC>ttT	p.F113F	PREX1_ENST00000371941.3_Silent_p.F113F			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	113	DH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AGGCGGCCAAGAAATCCTTAT	0.502000													21	268					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45878105	45878105	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45878105G>A	ENST00000374391.2	+	2	378	c.325G>A	c.(325-327)Gag>Aag	p.E109K	ALOX5_ENST00000542434.1_Missense_Mutation_p.E109K	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	109	PLAT.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CGGCGATGTCGAGGTTGTCCT	0.592000													3	11					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161025734	161025734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:161025734G>A	ENST00000283249.2	-	7	1243	c.1006C>T	c.(1006-1008)Cat>Tat	p.H336Y	ITGB6_ENST00000485635.1_5'UTR|ITGB6_ENST00000409872.1_Missense_Mutation_p.H336Y|ITGB6_ENST00000428609.2_Missense_Mutation_p.H294Y|ITGB6_ENST00000409967.2_Missense_Mutation_p.H336Y			P18564	ITB6_HUMAN	integrin, beta 6	336	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						TCATATAAATGAACTTGTTCT	0.323000													32	83					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10425540	10425540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10425540C>T	ENST00000377086.1	+	43	4788	c.4586C>T	c.(4585-4587)tCg>tTg	p.S1529L	KIF1B_ENST00000263934.6_Missense_Mutation_p.S1483L|KIF1B_ENST00000377081.1_Missense_Mutation_p.S1529L			O60333	KIF1B_HUMAN	kinesin family member 1B	1529					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CTGAGCGACTCGTTATCCCCC	0.527000													7	85					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25543330	25543330	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:25543330G>A	ENST00000269141.3	-	15	2928	c.2505C>T	c.(2503-2505)ttC>ttT	p.F835F	CDH2_ENST00000399380.3_Silent_p.F804F|AC015933.2_ENST00000423367.1_RNA	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	835					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCTCATTAATGAAGTCCCCAA	0.488000													9	29					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125872343	125872343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125872343G>A	ENST00000393434.2	-	7	1151	c.802C>T	c.(802-804)Cgg>Tgg	p.R268W	ALDH1L1_ENST00000393431.2_Missense_Mutation_p.R268W|ALDH1L1_ENST00000472186.1_Missense_Mutation_p.R268W|ALDH1L1_ENST00000452905.2_Missense_Mutation_p.R167W|ALDH1L1_ENST00000273450.3_Missense_Mutation_p.R278W|ALDH1L1_ENST00000455064.2_Missense_Mutation_p.R93W|ALDH1L1_ENST00000413612.1_5'UTR	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	268					10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	ACCCCTGGCCGATGGGCTCCT	0.542000													31	71					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71747982	71747982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71747982G>A	ENST00000258104.3	+	11	1278	c.1001G>A	c.(1000-1002)aGa>aAa	p.R334K	DYSF_ENST00000410041.1_Missense_Mutation_p.R366K|DYSF_ENST00000429174.2_Missense_Mutation_p.R334K|DYSF_ENST00000409744.1_Missense_Mutation_p.R335K|DYSF_ENST00000410020.3_Missense_Mutation_p.R366K|DYSF_ENST00000394120.2_Missense_Mutation_p.R335K|DYSF_ENST00000409366.1_Missense_Mutation_p.R335K|DYSF_ENST00000409582.3_Missense_Mutation_p.R365K|DYSF_ENST00000413539.2_Missense_Mutation_p.R365K|DYSF_ENST00000409651.1_Missense_Mutation_p.R366K|DYSF_ENST00000409762.1_Missense_Mutation_p.R365K	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	334						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GCTGGGGCCAGAGGCTACCTG	0.572000													27	92					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11607595	11607595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11607595G>A	ENST00000262442.3	+	25	5295	c.5227G>A	c.(5227-5229)Gag>Aag	p.E1743K	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1743K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1743	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGAAGGCTATGAGAGTGCCAT	0.527000													27	43					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45459056	45459056	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45459056C>T	ENST00000548424.1	+	0	448																											AATTGGAGTTCGTTTCCTTCC	0.443000													13	26					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235969221	235969221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:235969221G>A	ENST00000389794.3	-	6	3389	c.3215C>T	c.(3214-3216)tCc>tTc	p.S1072F	LYST_ENST00000536965.1_Missense_Mutation_p.S1072F|LYST_ENST00000389793.2_Missense_Mutation_p.S1072F			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1072					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CACATTTATGGAAGAAATATG	0.383000													43	65					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183976274	183976274	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183976274C>T	ENST00000324557.4	+	3	724	c.679C>T	c.(679-681)Caa>Taa	p.Q227*	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000402825.3_Intron	NM_032331.3	NP_115707.2	O60344	ECE2_HUMAN	endothelin converting enzyme 2	0	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTGGGGGCCCAAATCCTCTC	0.582000													40	128					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834479	125834479	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125834479G>A	ENST00000299308.3	+	2	542	c.534G>A	c.(532-534)ggG>ggA	p.G178G	TMEM132B_ENST00000418253.2_3'UTR	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	178						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGCTGCAAGGGGCCCCAGGGC	0.627000													26	73					0	0	1	0	0
IGFBP2	3485	broad.mit.edu	37	2	217525496	217525496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:217525496C>T	ENST00000233809.4	+	2	788	c.659C>T	c.(658-660)cCa>cTa	p.P220L	IGFBP2_ENST00000456764.1_Missense_Mutation_p.P76L	NM_000597.2	NP_000588.2	P18065	IBP2_HUMAN	insulin-like growth factor binding protein 2, 36kDa	220					positive regulation of activated T cell proliferation|regulation of cell growth|regulation of insulin-like growth factor receptor signaling pathway	extracellular space	insulin-like growth factor I binding|insulin-like growth factor II binding			endometrium(2)|large_intestine(1)|lung(2)	5		Renal(323;0.0458)		Epithelial(149;2.9e-06)|all cancers(144;0.000223)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00968)		AAGCTGCGACCACCCCCTGCC	0.627000													5	10					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41585335	41585335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41585335C>T	ENST00000402685.2	+	2	732	c.724C>T	c.(724-726)Cga>Tga	p.R242*		NM_001164595.1	NP_001158067.1	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	242	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TATAGGAGGTCGACCAAATCA	0.303000													14	34					0	0	1	0	0
HP	3240	broad.mit.edu	37	16	72094210	72094210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72094210G>A	ENST00000355906.5	+	7	700	c.642G>A	c.(640-642)gcG>gcA	p.A214A	HP_ENST00000565574.1_Silent_p.A155A|HP_ENST00000570083.1_Silent_p.A155A|HP_ENST00000562526.1_Intron|HP_ENST00000398131.2_Silent_p.A155A|HPR_ENST00000356967.5_Intron	NM_005143.3	NP_005134.1	P00738	HPT_HUMAN	haptoglobin	214	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|urinary_tract(1)	7		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		ATGCAACAGCGAAAGACATTG	0.453000													23	50					0	0	1	0	0
MAPK14	1432	broad.mit.edu	37	6	36040749	36040749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36040749C>T	ENST00000229795.3	+	4	852	c.405C>T	c.(403-405)ctC>ctT	p.L135L	MAPK14_ENST00000468133.1_Silent_p.L58L|MAPK14_ENST00000310795.4_Silent_p.L135L|MAPK14_ENST00000229794.4_Silent_p.L135L	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	135	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						ACCAAATTCTCCGAGGTCTAA	0.378000													15	40					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181480566	181480566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181480566G>A	ENST00000526775.1	+	3	597	c.432G>A	c.(430-432)gtG>gtA	p.V144V	CACNA1E_ENST00000367570.1_Silent_p.V144V|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000360108.3_Silent_p.V144V|CACNA1E_ENST00000357570.5_Silent_p.V95V|CACNA1E_ENST00000358338.5_Silent_p.V95V|CACNA1E_ENST00000367573.2_Silent_p.V144V	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	144					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TCAAAATTGTGGCCCTGGGGT	0.488000													77	172					0	0	1	0	0
SLC16A13	201232	broad.mit.edu	37	17	6941598	6941598	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6941598C>T	ENST00000308027.6	+	3	779	c.471C>T	c.(469-471)ccC>ccT	p.P157P		NM_201566.2	NP_963860.1	Q7RTY0	MOT13_HUMAN	solute carrier family 16, member 13	157						integral to membrane|plasma membrane	symporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						CATTTGCCCCCTTTTTCCAGT	0.652000													30	30					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56108789	56108789	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:56108789G>A	ENST00000394555.2	-	5	1033	c.598C>T	c.(598-600)Cag>Tag	p.Q200*	EFEMP1_ENST00000394554.1_Nonsense_Mutation_p.Q200*|EFEMP1_ENST00000355426.3_Nonsense_Mutation_p.Q200*|EFEMP1_ENST00000424836.2_Nonsense_Mutation_p.Q142*	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	200	EGF-like 2; calcium-binding (Potential).				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGAGGGCACTGACATGCAAAG	0.517000													21	83					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39170381	39170381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39170381C>T	ENST00000301819.6	+	14	2055	c.1878C>T	c.(1876-1878)atC>atT	p.I626I	TTC21A_ENST00000431162.2_Silent_p.I625I|TTC21A_ENST00000440121.1_Silent_p.I577I	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	625							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GGGCATCCATCTTATTGGAAC	0.552000													31	68					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896999	175896999	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175896999G>A	ENST00000359240.3	+	5	993	c.323G>A	c.(322-324)gGg>gAg	p.G108E	ADAM29_ENST00000445694.1_Missense_Mutation_p.G108E|ADAM29_ENST00000404450.4_Missense_Mutation_p.G108E|ADAM29_ENST00000514159.1_Missense_Mutation_p.G108E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	108					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TATGTGGAAGGGGACCCAGAA	0.453000													12	61					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6711072	6711072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6711072C>T	ENST00000245907.6	-	12	1497	c.1405G>A	c.(1405-1407)Gag>Aag	p.E469K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	469			E -> D (in dbSNP:rs11569422).		complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TTGAGGGTCTCCCCGGGTCTG	0.602000													26	199					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159921563	159921563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159921563C>T	ENST00000368093.3	-	4	874	c.758G>A	c.(757-759)gGa>gAa	p.G253E	SLAMF9_ENST00000368092.3_Missense_Mutation_p.G162E|SLAMF9_ENST00000466773.1_5'UTR	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	253						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GACCCAGAGTCCCATGGCCAG	0.488000													48	102					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3520891	3520891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3520891C>T	ENST00000262919.5	+	3	585	c.517C>T	c.(517-519)Cgt>Tgt	p.R173C	ATRN_ENST00000446916.2_Missense_Mutation_p.R173C	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	173	CUB.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding	p.R173C(1)		breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						AATGAGACTTCGTTTCAATCA	0.308000													52	234					0	0	1	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153279643	153279643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153279643G>A	ENST00000290722.1	-	2	208	c.156C>T	c.(154-156)ctC>ctT	p.L52L		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	52					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCATCCCTGGGAGCTGGTCTG	0.632000													6	8					0	0	1	0	0
CEACAM3	1084	broad.mit.edu	37	19	42300634	42300634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42300634C>T	ENST00000357396.3	+	1	266	c.25C>T	c.(25-27)Cac>Tac	p.H9Y	CEACAM3_ENST00000221999.4_Missense_Mutation_p.H9Y|CEACAM3_ENST00000344550.4_Missense_Mutation_p.H9Y|CEACAM3_ENST00000595255.1_3'UTR	NM_001815.2	NP_001806.2	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 3	9						integral to membrane		p.H9Y(1)		endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(3)|skin(4)|stomach(1)	19						AGCCTCTCCCCACAGAGAATG	0.602000													25	43					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118314941	118314941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118314941C>T	ENST00000369221.2	+	8	761	c.733C>T	c.(733-735)Cca>Tca	p.P245S		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	245					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity	p.P245A(2)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AGATTTCTTTCCAAATGGAGG	0.388000													54	117					0	0	1	0	0
MICU3	286097	broad.mit.edu	37	8	16935338	16935338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16935338C>T	ENST00000318063.5	+	4	656	c.614C>T	c.(613-615)tCa>tTa	p.S205L		NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		TGGAAAGGCTCATCGAAGCTA	0.284000													17	45					0	0	1	0	0
IGHD	3495	broad.mit.edu	37	14	106311229	106311229	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106311229G>A	ENST00000390556.2	-	0	333																											TTGTGCAGTGGGCACTGAGGA	0.607000													5	12					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69881562	69881562	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:69881562C>T	ENST00000358913.5	+	2	855	c.367C>T	c.(367-369)Cga>Tga	p.R123*	MYPN_ENST00000354393.2_Intron|MYPN_ENST00000540630.1_Nonsense_Mutation_p.R123*|MYPN_ENST00000373675.3_Nonsense_Mutation_p.R123*	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	123	Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GGATAACCCTCGAAGTCCCAC	0.433000													6	67					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149493792	149493792	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149493792C>T	ENST00000378016.2	+	0	6788							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGATGGCTCGGATGAGGAG	0.657000													3	17					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81372163	81372163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81372163G>A	ENST00000398636.3	+	4	406	c.268G>A	c.(268-270)Gag>Aag	p.E90K	SFTPA1_ENST00000428376.2_Missense_Mutation_p.E90K|SFTPA1_ENST00000372308.3_Missense_Mutation_p.E90K|SFTPA1_ENST00000419470.2_Missense_Mutation_p.E105K|SFTPA1_ENST00000372313.5_Missense_Mutation_p.E31K	NM_001164644.1|NM_001164646.1|NM_005411.4	NP_001158116.1|NP_001158118.1|NP_005402.3	Q8IWL2	SFTA1_HUMAN	surfactant protein A1	90	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			AGAGAAGGGGGAGCCTGGCGA	0.632000													11	182					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422620	26422620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26422620C>T	ENST00000335473.7	+	43	6930	c.6680C>T	c.(6679-6681)cCc>cTc	p.P2227L	MYO18B_ENST00000536101.1_Missense_Mutation_p.P2227L|MYO18B_ENST00000407587.2_Missense_Mutation_p.P2228L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2227						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCTTCCTCTCCCCTGGCTTCT	0.577000													12	45					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026326	79026326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79026326G>A	ENST00000446378.2	+	2	1769	c.1738G>A	c.(1738-1740)Gaa>Aaa	p.E580K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	580	Glu-rich.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTTGTCTGAGGAAGAAAGAGA	0.423000													112	310					0	0	1	0	0
SYN3	8224	broad.mit.edu	37	22	33260980	33260980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:33260980G>A	ENST00000358763.2	-	6	875	c.633C>T	c.(631-633)ctC>ctT	p.L211L	SYN3_ENST00000332840.5_Silent_p.L211L	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	211	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						AGATCTTAATGAGCTGAGAGA	0.453000													66	147					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151789722	151789722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151789722C>T	ENST00000356728.6	-	2	196	c.42G>A	c.(40-42)ggG>ggA	p.G14G	RORC_ENST00000318247.6_Silent_p.G35G|RORC_ENST00000392697.3_Silent_p.G89G	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	35	Modulating (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACGACTTGTCCCCACAGATTT	0.498000													20	65					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140907670	140907670	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140907670G>A	ENST00000371372.1	+	18	2395	c.2250G>A	c.(2248-2250)gcG>gcA	p.A750A	CACNA1B_ENST00000371357.1_Silent_p.A751A|CACNA1B_ENST00000371363.1_Silent_p.A750A|CACNA1B_ENST00000277551.2_Silent_p.A750A|CACNA1B_ENST00000371355.4_Silent_p.A751A|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000277550.3_Silent_p.A41A	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	750					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGTCTGCCGCGAACATCTCCA	0.592000													8	29					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22364370	22364370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22364370G>A	ENST00000397121.2	-	3	466	c.149C>T	c.(148-150)tCc>tTc	p.S50F		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAACTCTTGGGAAAAATGAGA	0.274000													13	23					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52619652	52619652	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52619652C>T	ENST00000282641.2	-	3	236	c.49G>A	c.(49-51)Gaa>Aaa	p.E17K	A1CF_ENST00000395495.1_Missense_Mutation_p.E17K|A1CF_ENST00000373993.1_Missense_Mutation_p.E17K|A1CF_ENST00000395489.2_5'UTR|A1CF_ENST00000374001.1_Missense_Mutation_p.E17K|A1CF_ENST00000373995.3_5'UTR|A1CF_ENST00000373997.3_Missense_Mutation_p.E17K	NM_138932.2	NP_620310.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	17					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						AGGGCTGCTTCCTTCTGAGTG	0.483000													36	54					0	0	1	0	0
DCAF16	54876	broad.mit.edu	37	4	17805519	17805519	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:17805519A>C	ENST00000382247.1	-	3	1306	c.246T>G	c.(244-246)gaT>gaG	p.D82E	DCAF16_ENST00000536863.1_Missense_Mutation_p.D82E	NM_017741.3	NP_060211.3	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	82						CUL4 RING ubiquitin ligase complex				cervix(1)|endometrium(1)|lung(2)|ovary(1)	5						GTGTGCTTGGATCCAACAGTT	0.438000													19	112					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110833706	110833706	+	Missense_Mutation	SNP	G	G	A	rs150129180	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110833706G>A	ENST00000375820.4	-	29	2247	c.2126C>T	c.(2125-2127)cCa>cTa	p.P709L		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	709	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGTCCCCGGTGGCCCCATGTC	0.507000													11	22					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41419023	41419023	+	Silent	SNP	G	G	A	rs145714777		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41419023G>A	ENST00000551295.2	+	21	2712	c.2595G>A	c.(2593-2595)tcG>tcA	p.S865S	CNTN1_ENST00000550305.1_3'UTR|CNTN1_ENST00000348761.2_Silent_p.S854S|CNTN1_ENST00000347616.1_Silent_p.S865S	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	865	Fibronectin type-III 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AAGAGTACTCGGCCAGGCTCG	0.483000													64	205					0	0	1	0	0
NANOG	79923	broad.mit.edu	37	12	7945794	7945794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7945794C>T	ENST00000229307.4	+	2	619	c.400C>T	c.(400-402)Ctc>Ttc	p.L134F	NANOG_ENST00000526286.1_Missense_Mutation_p.L134F	NM_024865.2	NP_079141.2	Q9H9S0	NANOG_HUMAN	Nanog homeobox	134					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14				Kidney(36;0.0872)		CATCCTGAACCTCAGCTACAA	0.438000													4	42					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139756733	139756733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139756733C>T	ENST00000263549.3	-	3	1556	c.683G>A	c.(682-684)aGa>aAa	p.R228K		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	228						nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					ATGTGCATTTCTATAAATGGT	0.473000													33	126					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2972186	2972186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2972186C>T	ENST00000396946.4	-	11	1956	c.1553G>A	c.(1552-1554)cGa>cAa	p.R518Q		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	518					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		ATCTGATGTTCGCTTCAGGCT	0.493000			Mis		DLBCL								7	25					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160784397	160784397	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160784397G>A	ENST00000263285.5	+	4	948	c.918G>A	c.(916-918)agG>agA	p.R306R	LY9_ENST00000368035.1_5'UTR|LY9_ENST00000471816.1_3'UTR|LY9_ENST00000368041.2_Silent_p.R266R|LY9_ENST00000341032.4_Silent_p.R306R|LY9_ENST00000368040.1_5'UTR	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	306	Ig-like V-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTAAATCCAGGGATCCTTACA	0.532000													6	54					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197404228	197404228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197404228G>A	ENST00000367397.1	+	5	2236	c.1378G>A	c.(1378-1380)Gat>Aat	p.D460N	CRB1_ENST00000544212.1_Missense_Mutation_p.D560N|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.D967N|CRB1_ENST00000535699.1_Missense_Mutation_p.D1055N|CRB1_ENST00000367400.3_Missense_Mutation_p.D1079N			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1079	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GGATAATACAGATATTTATGT	0.418000													19	109					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081480	152081480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152081480C>T	ENST00000368804.1	-	2	4212	c.4213G>A	c.(4213-4215)Gag>Aag	p.E1405K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1405	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGTTGCTCGCGCTCCTGG	0.577000													46	135					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322632	55322632	+	Missense_Mutation	SNP	G	G	A	rs72140406		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55322632G>A	ENST00000314644.2	+	1	850	c.850G>A	c.(850-852)Gaa>Aaa	p.E284K		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						ACACAGTTCTGAAGGGCGCTG	0.453000										HNSCC(20;0.049)			29	139					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19319266	19319266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:19319266C>T	ENST00000461366.1	+	14	1889	c.1674C>T	c.(1672-1674)ctC>ctT	p.L558L		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	558							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						GGGCCGGGCTCATGGGCCTGG	0.687000													8	4					0	0	1	0	0
HTRA1	5654	broad.mit.edu	37	10	124266334	124266334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124266334G>A	ENST00000368984.3	+	4	1033	c.905G>A	c.(904-906)cGa>cAa	p.R302Q		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	302	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				ACCACCCAGCGAGGCGGCAAA	0.622000													27	72					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401599	89401599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89401599C>T	ENST00000439576.2	+	12	6157	c.5783C>T	c.(5782-5784)cCa>cTa	p.P1928L	ACAN_ENST00000352105.7_Missense_Mutation_p.P1928L|ACAN_ENST00000559004.1_Missense_Mutation_p.P1928L|ACAN_ENST00000561243.1_Missense_Mutation_p.P1928L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1928					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTGGAACTCCATCTAGTTTC	0.537000													25	75					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226033	158226033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158226033G>A	ENST00000289429.5	+	3	1098	c.565G>A	c.(565-567)Ggt>Agt	p.G189S		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	189	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TTTCATCTTGGGTCTTCTTGA	0.458000													17	85					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107692680	107692680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107692680C>T	ENST00000388781.3	-	26	3861	c.3778G>A	c.(3778-3780)Gaa>Aaa	p.E1260K	LAMB4_ENST00000205386.4_Missense_Mutation_p.E1260K|LAMB4_ENST00000388780.3_Missense_Mutation_p.E1260K	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1260	Domain II.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TTCAGTTGTTCATTTAGCTGC	0.323000													14	95					0	0	1	0	0
ELOVL7	79993	broad.mit.edu	37	5	60067864	60067864	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:60067864G>A	ENST00000505959.1	-	6	608	c.82C>T	c.(82-84)Cta>Tta	p.L28L	ELOVL7_ENST00000425382.1_Silent_p.L41L|ELOVL7_ENST00000438340.1_Silent_p.L41L|ELOVL7_ENST00000508821.1_Silent_p.L41L			A1L3X0	ELOV7_HUMAN	ELOVL fatty acid elongase 7	41					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	9		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				TAGAATCCTAGGAGGATGGTT	0.423000													13	17					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199219	4199219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:4199219G>A	ENST00000296358.4	-	5	1366	c.1342C>T	c.(1342-1344)Cac>Tac	p.H448Y		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	448					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGCTCTCGGTGAATGGATTCA	0.547000													22	96					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228526038	228526038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228526038G>A	ENST00000570156.2	+	79	19994	c.19920G>A	c.(19918-19920)gaG>gaA	p.E6640E	OBSCN_ENST00000366707.4_Silent_p.E3317E|OBSCN_ENST00000422127.1_Silent_p.E5683E|OBSCN_ENST00000284548.11_Silent_p.E5683E|OBSCN_ENST00000366709.4_Silent_p.E2802E	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5683	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCCTGGGGAGGCTGTGTCTG	0.632000													6	8					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577519	9577519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9577519G>A	ENST00000301480.4	-	10	2317	c.2104C>T	c.(2104-2106)Cgc>Tgc	p.R702C		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	702					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						GTTTTTAAGCGATCATGAAAG	0.378000													60	195					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70236545	70236545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:70236545C>T	ENST00000342771.4	+	11	2066	c.1745C>T	c.(1744-1746)tCc>tTc	p.S582F	AUTS2_ENST00000406775.2_Missense_Mutation_p.S582F	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	582										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CTCTTCCATTCCTATCCTCCT	0.493000													38	79					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101016248	101016248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101016248G>A	ENST00000360863.6	-	17	2727	c.2533C>T	c.(2533-2535)Cct>Tct	p.P845S	RGS22_ENST00000523437.1_Missense_Mutation_p.P833S|RGS22_ENST00000519421.1_5'UTR|RGS22_ENST00000523287.1_Missense_Mutation_p.P664S	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	845					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TATTCTGCAGGAACATTATCC	0.373000													22	60					0	0	1	0	0
PER2	8864	broad.mit.edu	37	2	239161976	239161976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239161976G>A	ENST00000254657.3	-	19	2967	c.2688C>T	c.(2686-2688)ttC>ttT	p.F896F	PER2_ENST00000254658.3_3'UTR|AC096574.4_ENST00000456601.1_RNA	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	896	Pro-rich.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		AAGGGGCAGGGAAAGGTGGGG	0.652000													22	37					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77945045	77945045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77945045C>T	ENST00000493585.1	-	4	663	c.641G>A	c.(640-642)aGa>aAa	p.R214K	ISM2_ENST00000429906.1_Silent_p.Q248Q|ISM2_ENST00000342219.4_Silent_p.Q329Q|ISM2_ENST00000393684.3_Silent_p.Q241Q|ISM2_ENST00000412904.1_Silent_p.Q248Q	NM_182509.3	NP_872315.2	Q6H9L7	ISM2_HUMAN	isthmin 2	0						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						TCCACTCCTTCTGAGGCTCAT	0.582000													24	47					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56136651	56136651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56136651G>A	ENST00000319441.4	+	2	348	c.184G>A	c.(184-186)Gaa>Aaa	p.E62K	PCK1_ENST00000543666.1_5'UTR|PCK1_ENST00000535860.1_5'UTR	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	62					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCAGATGGAGGAAGAGGGCAT	0.607000													41	81					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193361862	193361862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:193361862C>T	ENST00000361510.2	+	16	1810	c.1576C>T	c.(1576-1578)Ctg>Ttg	p.L526L	OPA1_ENST00000361150.2_Silent_p.L472L|OPA1_ENST00000361715.2_Silent_p.L490L|OPA1_ENST00000361828.2_Silent_p.L489L|OPA1_ENST00000361908.3_Silent_p.L508L|OPA1_ENST00000392438.3_Silent_p.L471L	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	471					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		CAAAGTAGACCTGGCAGAGAA	0.433000													32	44					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55138596	55138596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55138596C>T	ENST00000257290.5	+	9	1604	c.1273C>T	c.(1273-1275)Cat>Tat	p.H425Y	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	425	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CGATGATCACCATGGCTCAAC	0.468000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			28	94					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227886797	227886797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227886797C>T	ENST00000396625.3	-	44	4390	c.4183G>A	c.(4183-4185)Ggg>Agg	p.G1395R	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1392R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1395	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCAGGGAGCCCCATGGCTCCT	0.522000													56	174					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50208317	50208317	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50208317C>T	ENST00000392518.4	+	9	1197	c.825C>T	c.(823-825)gcC>gcT	p.A275A	CPT1C_ENST00000405931.2_Silent_p.A264A|CPT1C_ENST00000323446.5_Silent_p.A275A|CPT1C_ENST00000354199.5_Silent_p.A275A|CPT1C_ENST00000598293.1_Silent_p.A275A	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	275					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CTGGGAATGCCGTCCATGCCC	0.647000													34	63					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791659	95791659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95791659G>A	ENST00000260766.3	+	2	1490	c.856G>A	c.(856-858)Gac>Aac	p.D286N	PLCE1_ENST00000371380.2_Missense_Mutation_p.D286N	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	286					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TTGTAGGAAAGACTTTACTGA	0.378000													32	128					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39377166	39377166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39377166G>A	ENST00000545653.1	-	11	2190	c.1660C>T	c.(1660-1662)Cct>Tct	p.P554S	DAB2_ENST00000509337.1_Missense_Mutation_p.P554S|DAB2_ENST00000339788.6_Missense_Mutation_p.P357S|DAB2_ENST00000320816.6_Missense_Mutation_p.P575S	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	575					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GATGCAGAAGGGCCCCAGACA	0.532000											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	59					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82402423	82402423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:82402423G>A	ENST00000370728.1	+	7	944	c.299G>A	c.(298-300)cGa>cAa	p.R100Q	LPHN2_ENST00000370723.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000335786.5_Missense_Mutation_p.R100Q|LPHN2_ENST00000370715.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370725.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000359929.3_Missense_Mutation_p.R100Q|LPHN2_ENST00000394879.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370727.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370730.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370717.2_Missense_Mutation_p.R100Q|LPHN2_ENST00000319517.6_Missense_Mutation_p.R100Q|LPHN2_ENST00000370713.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370721.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000271029.4_Missense_Mutation_p.R100Q			O95490	LPHN2_HUMAN	latrophilin 2	100	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TGCAACAATCGAACACAGTGT	0.318000													39	87					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111854894	111854894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111854894C>T	ENST00000369740.1	+	4	241	c.138C>T	c.(136-138)atC>atT	p.I46I	CHIA_ENST00000353665.6_Intron|CHIA_ENST00000343320.6_Silent_p.I46I|CHIA_ENST00000430615.1_Intron|CHIA_ENST00000451398.2_Intron|CHIA_ENST00000483391.1_Intron	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	46					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		CTGACAACATCGACCCCTGCC	0.567000													39	88					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10079019	10079019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:10079019G>A	ENST00000382452.2	-	14	1905	c.1623C>T	c.(1621-1623)tcC>tcT	p.S541S	WDR1_ENST00000499869.2_Silent_p.S541S|WDR1_ENST00000502702.1_Silent_p.S401S|WDR1_ENST00000382451.2_Silent_p.S401S|WDR1_ENST00000515743.1_5'UTR	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	541					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CATTGTCTGGGGACCAGGCCA	0.507000													22	88					0	0	1	0	0
AP5B1	91056	broad.mit.edu	37	11	65545600	65545600	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65545600G>A	ENST00000532090.2	-	2	2574	c.2364C>T	c.(2362-2364)tcC>tcT	p.S788S		NM_138368.4	NP_612377.4	Q2VPB7	YK046_HUMAN	adaptor-related protein complex 5, beta 1 subunit	731							protein binding			lung(1)	1						CTGGCAGGCAGGAATCCCAGA	0.632000													38	88					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39495058	39495058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39495058G>A	ENST00000265707.5	+	9	708	c.663G>A	c.(661-663)atG>atA	p.M221I	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.M197I	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	221	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			ATTTTTAGATGTTTACCCAGT	0.289000													10	35					0	0	1	0	0
FANCG	2189	broad.mit.edu	37	9	35079515	35079515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35079515G>A	ENST00000378643.3	-	1	498	c.7C>T	c.(7-9)Cgc>Tgc	p.R3C		NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	3					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTGGTCTGGCGGGACATGGTG	0.662000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					19	101					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17522690	17522690	+	Missense_Mutation	SNP	G	G	A	rs140313023		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17522690G>A	ENST00000005226.7	-	23	2287	c.2288C>T	c.(2287-2289)tCc>tTc	p.S763F	USH1C_ENST00000318024.4_Missense_Mutation_p.S463F|USH1C_ENST00000527720.1_Missense_Mutation_p.S432F|USH1C_ENST00000527020.1_Missense_Mutation_p.S444F|USH1C_ENST00000529563.1_5'UTR	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	463					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						CAGGTCTAAGGATCCCTCCTG	0.592000													8	15					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846378	47846378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47846378G>A	ENST00000339488.4	-	3	2235	c.2202C>T	c.(2200-2202)ttC>ttT	p.F734F		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	734						integral to membrane	hedgehog receptor activity										ATACAAATGTGAAAAGCAGTG	0.403000													9	21					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332827	100332827	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:100332827G>A	ENST00000341853.1	-	0	1364					NR_003260.1																						TGACTACAACGAGGGACACAG	0.612000													14	112					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430821	43430821	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43430821C>T	ENST00000446844.3	-	0	846				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCCTTATTCTCCCTGGGGTTT	0.488000													73	366					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303874	151303874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151303874C>T	ENST00000370323.4	-	4	535	c.219G>A	c.(217-219)gaG>gaA	p.E73E	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Silent_p.E73E	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	73								p.E73D(1)		endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCAGAAACCTCCTCTGGGG	0.532000													55	47					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18181530	18181530	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18181530G>A	ENST00000321105.5	-	18	2500	c.2286C>T	c.(2284-2286)ccC>ccT	p.P762P	TOP3A_ENST00000542570.1_Silent_p.P667P|TOP3A_ENST00000540524.1_Silent_p.P292P	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	762					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						GGCGGCCAGAGGGCTGGCTAG	0.627000													31	49					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471878	47471878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:47471878C>T	ENST00000266581.4	-	2	1374	c.908G>A	c.(907-909)gGg>gAg	p.G303E	AMIGO2_ENST00000429635.1_Missense_Mutation_p.G303E|AMIGO2_ENST00000550413.1_Missense_Mutation_p.G303E|AMIGO2_ENST00000321382.3_Missense_Mutation_p.G303E	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	303	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane		p.G303V(1)		endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CAGTCTTTCCCCGACCTGAGC	0.483000													18	153					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679051	100679051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100679051G>A	ENST00000306151.4	+	3	4418	c.4354G>A	c.(4354-4356)Gaa>Aaa	p.E1452K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1452	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAAGGAAAGAC	0.493000													98	454					0	0	1	0	0
ITPA	3704	broad.mit.edu	37	20	3202495	3202495	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3202495C>T	ENST00000380113.3	+	7	612	c.420C>T	c.(418-420)atC>atT	p.I140I	ITPA_ENST00000455664.1_Silent_p.I123I|ITPA_ENST00000399838.3_Silent_p.I99I|ITPA_ENST00000483354.1_3'UTR	NM_033453.3	NP_258412.1	Q9BY32	ITPA_HUMAN	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	140					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			autonomic_ganglia(1)|large_intestine(3)|ovary(1)|stomach(1)	6						AGGGCCGGATCGTGGCACCCA	0.592000													16	23					0	0	1	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140782717	140782717	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140782717C>T	ENST00000573521.1	+	1	198	c.198C>T	c.(196-198)atC>atT	p.I66I	PCDHGA8_ENST00000398604.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGTCCGCATCGTCTCTAGAG	0.612000													40	86					0	0	1	0	0
MLC1	23209	broad.mit.edu	37	22	50521574	50521574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50521574G>A	ENST00000311597.5	-	3	812	c.206C>T	c.(205-207)tCg>tTg	p.S69L	MLC1_ENST00000535444.1_5'UTR|MLC1_ENST00000450140.2_Missense_Mutation_p.S69L|MLC1_ENST00000538737.1_Missense_Mutation_p.S69L|MLC1_ENST00000395876.2_Missense_Mutation_p.S69L|MLC1_ENST00000431262.2_Intron	NM_015166.3	NP_055981.1	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with subcortical cysts 1	69						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(3)	18		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		CAGGTACAGCGAAAACCCCGA	0.607000													26	72					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530577	140530577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140530577G>A	ENST00000231136.1	+	1	739	c.739G>A	c.(739-741)Gaa>Aaa	p.E247K	PCDHB6_ENST00000543635.1_Missense_Mutation_p.E111K	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		247	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGCTCTATGAAGCACAAGT	0.547000													19	39					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953629	140953629	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140953629C>T	ENST00000277549.5	+	31	4729	c.2160C>T	c.(2158-2160)gcC>gcT	p.A720A	CACNA1B_ENST00000371357.1_Silent_p.A1525A|CACNA1B_ENST00000371363.1_Silent_p.A1524A|CACNA1B_ENST00000277551.2_Silent_p.A1524A|CACNA1B_ENST00000371355.4_Silent_p.A1525A|CACNA1B_ENST00000371372.1_Silent_p.A1524A			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1524					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGATCATCGCCTTTGGGGTGC	0.498000													4	11					0	0	1	0	0
PTGES	9536	broad.mit.edu	37	9	132510954	132510954	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:132510954G>A	ENST00000340607.4	-	2	223	c.189C>T	c.(187-189)ccC>ccT	p.P63P	PTGES_ENST00000481476.1_5'UTR	NM_004878.4	NP_004869.1	O14684	PTGES_HUMAN	prostaglandin E synthase	63					prostaglandin biosynthetic process|signal transduction	integral to membrane|membrane fraction	glutathione binding|prostaglandin-E synthase activity			lung(1)|skin(1)	2		Ovarian(14;0.00556)				GTTCCACGTCGGGGTCGCTCC	0.602000													5	20					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42689053	42689053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42689053G>A	ENST00000397163.3	+	9	1390	c.1171G>A	c.(1171-1173)Gtc>Atc	p.V391I	CAPN3_ENST00000349748.3_Missense_Mutation_p.V343I|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000318023.7_Missense_Mutation_p.V391I|CAPN3_ENST00000357568.3_Missense_Mutation_p.V391I|CAPN3_ENST00000356316.3_Missense_Mutation_p.V304I	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	391	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		GCAGCACCAGGTCACTGAGGA	0.542000													5	78					0	0	1	0	0
SLC39A13	91252	broad.mit.edu	37	11	47436453	47436453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47436453G>A	ENST00000362021.4	+	8	954	c.912G>A	c.(910-912)aaG>aaA	p.K304K	SLC39A13_ENST00000533076.1_Silent_p.K304K|SLC39A13_ENST00000524928.1_3'UTR|SLC39A13_ENST00000354884.4_Silent_p.K304K	NM_001128225.2	NP_001121697.1	Q96H72	S39AD_HUMAN	solute carrier family 39 (zinc transporter), member 13	304					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|kidney(1)|lung(1)|prostate(1)	4				Lung(87;0.0936)		AGTCCCCCAAGGGAGTAGGTA	0.682000													23	56					0	0	1	0	0
DEFA4	1669	broad.mit.edu	37	8	6794376	6794376	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:6794376G>T	ENST00000297435.2	-	2	170	c.46C>A	c.(46-48)Cag>Aag	p.Q16K		NM_001925.1	NP_001916.1	P12838	DEF4_HUMAN	defensin, alpha 4, corticostatin	16					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	10				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		GCCCGGACCTGGAGGGCTACC	0.607000													7	44					8.12818e-05	8.14046e-05	1	1	0
PON1	5444	broad.mit.edu	37	7	94935616	94935616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94935616C>T	ENST00000222381.3	-	7	992	c.761G>A	c.(760-762)tGg>tAg	p.W254*	PON1_ENST00000542556.1_Nonsense_Mutation_p.W254*	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	254					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AGTTAAAGTCCAATTAGCATG	0.328000													36	170					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795593	142795593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142795593C>T	ENST00000370498.1	-	2	838	c.85G>A	c.(85-87)Gag>Aag	p.E29K		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	29										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TTCGGTGCCTCCTGCATCTGA	0.423000													21	20					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202461	140202461	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140202461C>T	ENST00000529859.1	+	1	1101	c.1101C>T	c.(1099-1101)gtC>gtT	p.V367V	PCDHA5_ENST00000529619.1_Silent_p.V367V|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000378126.3_Silent_p.V367V|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCACGGTCATTGCTCTGA	0.537000													53	93					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29886201	29886201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29886201G>A	ENST00000310624.6	+	4	2605	c.2572G>A	c.(2572-2574)Gac>Aac	p.D858N		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	864	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						GGAGAAGAAGGACAGCAAGAA	0.527000													8	23					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236949460	236949460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:236949460C>T	ENST00000409538.1	+	14	2998	c.2502C>T	c.(2500-2502)tcC>tcT	p.S834S	AGAP1_ENST00000304032.7_Silent_p.S622S|AGAP1_ENST00000336665.5_Silent_p.S569S|AGAP1_ENST00000428334.2_Silent_p.S461S			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	622					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GCGGGAACTCCCACTGTGTGG	0.627000													24	56					0	0	1	0	0
TCF7L2	6934	broad.mit.edu	37	10	114903687	114903687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:114903687C>T	ENST00000355995.4	+	7	1198	c.691C>T	c.(691-693)Cca>Tca	p.P231S	TCF7L2_ENST00000369397.4_Missense_Mutation_p.P208S|TCF7L2_ENST00000352065.5_Missense_Mutation_p.P208S|TCF7L2_ENST00000534894.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000545257.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000536810.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000369395.1_Missense_Mutation_p.P256S|TCF7L2_ENST00000543371.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000355717.4_Missense_Mutation_p.P255S|TCF7L2_ENST00000538897.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000542695.1_5'UTR|TCF7L2_ENST00000349937.2_Missense_Mutation_p.P231S|TCF7L2_ENST00000369389.1_5'UTR			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	231	Mediates interaction with MAD2L2.|Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		CTCAGGAATCCCACGGCCTCC	0.527000			T	VTI1A	colorectal								13	41					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163393520	163393520	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163393520G>A	ENST00000332142.5	-	3	477	c.378C>T	c.(376-378)atC>atT	p.I126I	KCNH7_ENST00000328032.4_Silent_p.I126I	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	126	PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CAAAATTAATGATGAACATCA	0.363000													61	139					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27350447	27350447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:27350447G>A	ENST00000429845.2	-	11	1048	c.686C>T	c.(685-687)tCc>tTc	p.S229F	NEK10_ENST00000341435.5_Missense_Mutation_p.S229F			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	229							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AGCCAGAAGGGAACCCAATAG	0.333000													8	22					0	0	1	0	0
OR4C11	219429	broad.mit.edu	37	11	55371088	55371088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55371088G>A	ENST00000302231.4	-	1	786	c.762C>T	c.(760-762)ttC>ttT	p.F254F		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	254					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						GTGTATATATGAATATACATG	0.438000													8	83					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27781201	27781201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27781201C>T	ENST00000261588.4	+	21	4014	c.3995C>T	c.(3994-3996)tCc>tTc	p.S1332F		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1332										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GTCCACGTCTCCCTGGATGGC	0.567000													68	136					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50158630	50158630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50158630C>T	ENST00000284509.6	-	26	3220	c.3079G>A	c.(3079-3081)Ggg>Agg	p.G1027R	ATP8B4_ENST00000559829.1_Missense_Mutation_p.G1027R	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1027					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GCAATGCTCCCCCAGATGAAG	0.383000													31	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9084263	9084263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9084263C>T	ENST00000397910.4	-	1	7755	c.7552G>A	c.(7552-7554)Ggc>Agc	p.G2518S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2518	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGAGAAAGCCCATGGCAGGT	0.512000													13	33					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169340494	169340494	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169340494G>A	ENST00000511577.1	-	19	2816	c.2569C>T	c.(2569-2571)Caa>Taa	p.Q857*	DDX60L_ENST00000505890.1_Nonsense_Mutation_p.Q857*|DDX60L_ENST00000260184.7_Nonsense_Mutation_p.Q857*			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	857	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ACCCATTTTTGGCGATGAGGA	0.368000													5	8					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9028347	9028347	+	Missense_Mutation	SNP	G	G	A	rs150243586	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9028347G>A	ENST00000397910.4	-	11	36648	c.36445C>T	c.(36445-36447)Cgc>Tgc	p.R12149C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12151	SEA 1.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGTCAGGGCGATGTGTGCAG	0.557000													48	120					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50103168	50103168	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50103168C>T	ENST00000418929.2	+	5	4330	c.4318C>T	c.(4318-4320)Ccc>Tcc	p.P1440S		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	619							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		TCCGGGGCTCCCCAGTGCCAA	0.612000													7	33					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124856640	124856640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124856640G>A	ENST00000356219.3	-	21	2890	c.2735C>T	c.(2734-2736)cCc>cTc	p.P912L	NCOR2_ENST00000404121.2_Missense_Mutation_p.P465L|NCOR2_ENST00000405201.1_Missense_Mutation_p.P912L|NCOR2_ENST00000404621.1_Missense_Mutation_p.P894L|NCOR2_ENST00000429285.2_Missense_Mutation_p.P894L|NCOR2_ENST00000397355.1_Missense_Mutation_p.P895L	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	912					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCTGTCCTGGGGGGCGCCCGA	0.706000													20	66					0	0	1	0	0
MEX3B	84206	broad.mit.edu	37	15	82335978	82335978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:82335978G>A	ENST00000329713.4	-	2	1668	c.1233C>T	c.(1231-1233)ttC>ttT	p.F411F	MEX3B_ENST00000558133.1_3'UTR	NM_032246.3	NP_115622.2	Q6ZN04	MEX3B_HUMAN	mex-3 RNA binding family member B	411					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)	19						CACCCCCGGGGAAGACCACGg	0.672000													10	23					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11504573	11504573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11504573G>A	ENST00000379237.1	-	15	2748	c.2354C>T	c.(2353-2355)cCc>cTc	p.P785L	USP6NL_ENST00000277575.5_Missense_Mutation_p.P802L	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	785						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						ATATCTCACGGGACTATCTAC	0.537000													56	164					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84564673	84564673	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84564673G>A	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							TTGTCGGCCAGAATTATCCTG	0.478000													6	26					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49831842	49831842	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49831842C>T	ENST00000527477.1	+	0	2067																											ACCCCTTTATCCCATAAAGCC	0.388000													60	94					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137928403	137928403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:137928403C>T	ENST00000409968.1	+	7	1796	c.1618C>T	c.(1618-1620)Cca>Tca	p.P540S	THSD7B_ENST00000272643.3_Missense_Mutation_p.P540S|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000413152.2_Missense_Mutation_p.P509S|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTGTGAGGATCCAATGTGCTA	0.512000													18	48					0	0	1	0	0
HIBADH	11112	broad.mit.edu	37	7	27689131	27689131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27689131G>A	ENST00000265395.2	-	2	419	c.213C>T	c.(211-213)ttC>ttT	p.F71F		NM_152740.3	NP_689953.1	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase	71					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(4)|kidney(2)|lung(3)|ovary(2)|prostate(1)	12			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	AGGCATCAGGGAACACATCAT	0.363000													22	43					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074991	9074991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9074991G>A	ENST00000397910.4	-	3	12658	c.12455C>T	c.(12454-12456)tCt>tTt	p.S4152F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4154	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCTTCCACAGAGGGAGGGCT	0.498000													8	100					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61865750	61865750	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61865750G>A	ENST00000280772.1	-	28	3432	c.3241C>T	c.(3241-3243)Cga>Tga	p.R1081*	ANK3_ENST00000355288.2_Nonsense_Mutation_p.R215*|ANK3_ENST00000503366.1_Nonsense_Mutation_p.R1082*|ANK3_ENST00000373827.2_Nonsense_Mutation_p.R1075*	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1081	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTTCACTTCGAAGAACAATG	0.383000													14	62					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204981969	204981969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204981969G>A	ENST00000367172.4	+	31	4115	c.3787G>A	c.(3787-3789)Gaa>Aaa	p.E1263K	NFASC_ENST00000513543.1_Missense_Mutation_p.E1085K|NFASC_ENST00000338586.6_Missense_Mutation_p.E1140K|NFASC_ENST00000367169.4_Missense_Mutation_p.E987K|NFASC_ENST00000360049.4_Missense_Mutation_p.E1085K|NFASC_ENST00000367171.4_Missense_Mutation_p.E1248K|NFASC_ENST00000401399.1_Missense_Mutation_p.E1156K|NFASC_ENST00000539706.1_Missense_Mutation_p.E1090K|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000367170.4_Missense_Mutation_p.E1184K|NFASC_ENST00000339876.6_Missense_Mutation_p.E1156K|NFASC_ENST00000404907.1_Missense_Mutation_p.E1090K|NFASC_ENST00000404076.1_Missense_Mutation_p.E1073K|NFASC_ENST00000338515.6_Missense_Mutation_p.E1173K			O94856	NFASC_HUMAN	neurofascin	1263					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGACCCCAAGGAAGAGGATGG	0.542000													33	93					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68617472	68617472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68617472G>A	ENST00000423218.2	-	18	2414	c.2319C>T	c.(2317-2319)gtC>gtT	p.V773V	ITGA11_ENST00000315757.7_Silent_p.V773V			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	773					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GATGTACCGAGACTCTGAGAG	0.622000													40	57					0	0	1	0	0
SET	6418	broad.mit.edu	37	9	131456259	131456259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131456259G>A	ENST00000322030.8	+	7	1105	c.748G>A	c.(748-750)Gaa>Aaa	p.E250K	SET_ENST00000477806.1_3'UTR|SET_ENST00000372688.4_Missense_Mutation_p.E239K|SET_ENST00000409104.3_Missense_Mutation_p.E241K|SET_ENST00000372692.4_Missense_Mutation_p.E263K	NM_003011.3	NP_003002.2	Q01105	SET_HUMAN	SET nuclear oncogene	263	Asp/Glu-rich (highly acidic).				DNA replication|mRNA metabolic process|negative regulation of histone acetylation|negative regulation of neuron apoptosis|negative regulation of transcription, DNA-dependent|nucleocytoplasmic transport|nucleosome assembly|nucleosome disassembly	cytosol|endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm|protein complex	histone binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity			endometrium(2)|kidney(1)|lung(2)	5		Myeloproliferative disorder(178;0.204)		GBM - Glioblastoma multiforme(294;3.1e-09)		agatattgacgaagaagggga	0.383000			T	NUP214	AML								8	21					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913356	77913356	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:77913356G>A	ENST00000321110.1	-	2	857	c.562C>T	c.(562-564)Ccc>Tcc	p.P188S		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	188	Pro-rich.						nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						GGCTCCTGGGGAGGTGGAAGC	0.542000													21	18					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66648120	66648120	+	Missense_Mutation	SNP	G	G	A	rs147474467		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:66648120G>A	ENST00000359626.5	+	14	1870	c.1706G>A	c.(1705-1707)cGa>cAa	p.R569Q		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	569					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				TAGCAACAACGAACTGTCTAC	0.498000													8	18					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090556	9090556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9090556G>A	ENST00000397910.4	-	1	1462	c.1259C>T	c.(1258-1260)aCc>aTc	p.T420I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	420	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAGTGATGGGTGTTGGTCTC	0.502000													21	56					0	0	1	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27911626	27911626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27911626C>T	ENST00000326019.6	+	12	2545	c.2263C>T	c.(2263-2265)Cca>Tca	p.P755S		NM_018158.2	NP_060628.2	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger), member 1, adaptor protein	755						cytoplasm|nucleus	double-stranded RNA binding|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.155)					AACACCTGGTCCAGGCAAAGT	0.353000													11	49					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086447	92086447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92086447C>T	ENST00000298047.6	+	1	1186	c.1169C>T	c.(1168-1170)cCt>cTt	p.P390L	FAT3_ENST00000525166.1_Missense_Mutation_p.P240L|FAT3_ENST00000409404.2_Missense_Mutation_p.P390L|FAT3_ENST00000541502.1_Missense_Mutation_p.P390L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	390	Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAATTTTCCCCTCCTGGTGTC	0.398000										TCGA Ovarian(4;0.039)			11	19					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74447035	74447035	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:74447035C>T	ENST00000339953.5	-	5	697	c.576G>A	c.(574-576)ggG>ggA	p.G192G		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	192						extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						TGATTGTCTTCCCGTTGACCT	0.627000													9	174					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76063292	76063292	+	Missense_Mutation	SNP	C	C	T	rs149762228		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76063292C>T	ENST00000393004.2	-	4	813	c.592G>A	c.(592-594)Gac>Aac	p.D198N	FILIP1_ENST00000237172.7_Missense_Mutation_p.D198N|FILIP1_ENST00000370020.1_Missense_Mutation_p.D99N			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	198										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GTGAAGTCGTCGCTCTTGTTC	0.532000													13	162					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113283333	113283333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113283333C>T	ENST00000362072.3	-	7	1427	c.1083G>A	c.(1081-1083)agG>agA	p.R361R	DRD2_ENST00000346454.3_Silent_p.R332R|DRD2_ENST00000542968.1_Silent_p.R361R|DRD2_ENST00000538967.1_Silent_p.R363R|DRD2_ENST00000355319.2_Silent_p.R363R|DRD2_ENST00000544518.1_Silent_p.R360R	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	361	Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGGAGAGCTTCCTACGGCTCA	0.567000													25	56					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206224750	206224750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206224750G>A	ENST00000367126.4	+	1	775	c.310G>A	c.(310-312)Gac>Aac	p.D104N		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	104					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCAGGGCCCCGACCTCCTGTG	0.632000													21	53					0	0	1	0	0
SNRPB	6628	broad.mit.edu	37	20	2442431	2442431	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2442431G>T	ENST00000438552.2	-	7	856	c.694C>A	c.(694-696)Ccc>Acc	p.P232T	SNRPB_ENST00000381342.2_3'UTR	NM_198216.1	NP_937859.1	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	232	Repeat-rich region.				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						ATTCCCGGGGGAGGGGGCCCT	0.547000													25	69					3.73148e-12	3.74869e-12	1	1	0
IGHD	3495	broad.mit.edu	37	14	106307412	106307412	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106307412C>T	ENST00000390556.2	-	0	625																											CTGTGGGGACCTTCCCGGCCA	0.662000													6	15					0	0	1	0	0
SEPT5	5413	broad.mit.edu	37	22	19707966	19707966	+	Silent	SNP	C	C	T	rs148378941		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19707966C>T	ENST00000438754.2	+	5	793	c.513C>T	c.(511-513)ccC>ccT	p.P171P	SEPT5_ENST00000455784.2_Silent_p.P162P|SEPT5_ENST00000383045.3_Silent_p.P171P|SEPT5_ENST00000406395.1_Silent_p.P162P	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	162					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					TCATCTCCCCCTTCGGGCATG	0.597000													22	59					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203420344	203420344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:203420344C>T	ENST00000374580.4	+	12	2495	c.1956C>T	c.(1954-1956)acC>acT	p.T652T	BMPR2_ENST00000374574.2_Intron	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	652					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						TTGGGCCAACCCCTGTCTGCT	0.443000													18	64					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57745893	57745893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57745893G>A	ENST00000281282.5	+	7	2145	c.2067G>A	c.(2065-2067)gtG>gtA	p.V689V		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	689						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TATTCCAGGTGAAGATGGAAC	0.517000													10	15					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065888	9065888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9065888C>T	ENST00000397910.4	-	3	21761	c.21558G>A	c.(21556-21558)gtG>gtA	p.V7186V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7188	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGAATCTCCACATTGGACG	0.507000													14	147					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138453020	138453020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138453020G>A	ENST00000344876.4	-	1	609	c.223C>T	c.(223-225)Cct>Tct	p.P75S	PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.P75S|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	75	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ACAAGTAGAGGAGAATTTCCC	0.418000													56	133					0	0	1	0	0
DYRK4	8798	broad.mit.edu	37	12	4705767	4705767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4705767G>A	ENST00000540757.2	+	6	592	c.432G>A	c.(430-432)caG>caA	p.Q144Q	DYRK4_ENST00000010132.5_Silent_p.Q144Q|DYRK4_ENST00000543431.1_Silent_p.Q144Q	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	144	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			TTCACCAGCAGGCCCTGATGG	0.522000													17	24					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282195	152282195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152282195C>T	ENST00000368799.1	-	3	5202	c.5167G>A	c.(5167-5169)Gag>Aag	p.E1723K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1723	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGTGTCCCTCGCTGTCACTG	0.597000									Ichthyosis				144	343					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18182980	18182980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18182980C>T	ENST00000600835.1	-	10	1266	c.963G>A	c.(961-963)tcG>tcA	p.S321S	IL12RB1_ENST00000593993.1_Silent_p.S321S|IL12RB1_ENST00000430026.2_Silent_p.S321S|IL12RB1_ENST00000322153.6_Silent_p.S321S			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	321	Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CAAATTGGTTCGAGGAGATGA	0.627000													17	35					0	0	1	0	0
OR5K4	403278	broad.mit.edu	37	3	98072952	98072952	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98072952C>T	ENST00000354924.2	+	1	255	c.255C>T	c.(253-255)ttC>ttT	p.F85F	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						TAGAGAATTTCTTTTCTGAGG	0.433000													165	356					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18668094	18668094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18668094C>T	ENST00000308799.4	+	7	1779	c.1560C>T	c.(1558-1560)ttC>ttT	p.F520F	FBXW10_ENST00000395667.1_Silent_p.F491F|FBXW10_ENST00000301938.4_Silent_p.F491F|FBXW10_ENST00000395665.4_Silent_p.F491F			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	491										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						CACGAATCTTCGGTGGTCACC	0.493000													27	32					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140055526	140055526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140055526G>A	ENST00000371561.3	+	9	2313	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K	GRIN1_ENST00000371553.3_Missense_Mutation_p.E427K|GRIN1_ENST00000315048.3_Missense_Mutation_p.E406K|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000350902.5_Missense_Mutation_p.E406K|GRIN1_ENST00000371546.4_Missense_Mutation_p.E427K|GRIN1_ENST00000371555.4_Missense_Mutation_p.E427K|GRIN1_ENST00000371559.4_Missense_Mutation_p.E406K|GRIN1_ENST00000371550.4_Missense_Mutation_p.E406K|GRIN1_ENST00000371560.3_Missense_Mutation_p.E427K	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	406					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GATCCACCAGGAGCCCTTCGT	0.627000													14	48					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147259245	147259245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:147259245C>T	ENST00000361727.3	+	12	2309	c.1793C>T	c.(1792-1794)tCc>tTc	p.S598F		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	598	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TACGAGCCTTCCTGTGAAGCC	0.448000										HNSCC(39;0.1)			10	72					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64418966	64418966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64418966C>T	ENST00000265459.6	-	14	3140	c.2679G>A	c.(2677-2679)atG>atA	p.M893I	NRXN2_ENST00000377551.1_Missense_Mutation_p.M893I|AP001092.4_ENST00000433606.1_RNA|NRXN2_ENST00000409571.1_Missense_Mutation_p.M886I|NRXN2_ENST00000377559.3_Missense_Mutation_p.M853I	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	893	Laminin G-like 4.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TGCACTGGTCCATGTAGGGCT	0.582000											OREG0021057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	37					0	0	1	0	0
GPR55	9290	broad.mit.edu	37	2	231775414	231775414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231775414G>A	ENST00000392040.1	-	2	456	c.264C>T	c.(262-264)tcC>tcT	p.S88S	GPR55_ENST00000392039.2_Silent_p.S88S	NM_005683.3	NP_005674.2	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	88					activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			endometrium(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		ACGGGAAGGGGGACTGTACCT	0.552000													24	57					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134896090	134896090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134896090G>A	ENST00000607359.1	+	6	1176	c.1176G>A	c.(1174-1176)agG>agA	p.R392R				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		ACTTGGGGAGGGGAGGCCTTT	0.587000													6	26					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57117372	57117372	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57117372G>A	ENST00000263314.2	+	7	739	c.705_splice	c.e7+1	p.T235_splice		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	235					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						TGGCGCGCACGGTGAGGACCT	0.642000											OREG0020966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	30					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	140990817	140990817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:140990817C>T	ENST00000389484.3	-	91	14709	c.13738G>A	c.(13738-13740)Gat>Aat	p.D4580N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4580					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCCTTTCATCAACACTTCCT	0.318000										TSP Lung(27;0.18)			15	55					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161300263	161300263	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:161300263G>A	ENST00000428797.2	+	6	751	c.396G>A	c.(394-396)aaG>aaA	p.K132K	GABRA1_ENST00000023897.6_Silent_p.K132K|GABRA1_ENST00000437025.2_Silent_p.K132K|GABRA1_ENST00000420560.1_Silent_p.K132K|GABRA1_ENST00000444819.1_Silent_p.K132K|GABRA1_ENST00000393943.4_Silent_p.K132K	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	132				Missing (in Ref. 4; CAA31925).	gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	ACAATGGAAAGAAGTCAGTGG	0.463000													9	55					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55658779	55658779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55658779G>A	ENST00000449290.2	+	7	1122	c.1030G>A	c.(1030-1032)Gag>Aag	p.E344K	TRIM51_ENST00000244891.3_Missense_Mutation_p.E201K	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	344	B30.2/SPRY.					intracellular	zinc ion binding										ATATTATTGGGAGGTTCATAT	0.433000													56	143					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711684	20711684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20711684G>A	ENST00000315409.2	+	1	787	c.734G>A	c.(733-735)aGa>aAa	p.R245K		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		GCTGGTCGGAGAAAAGCCTTC	0.433000													45	379					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135266134	135266134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135266134G>A	ENST00000334270.2	-	7	2111	c.2072C>T	c.(2071-2073)cCc>cTc	p.P691L		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	691	Myb-like 2.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TAACTCCTGGGGAGACATCTT	0.408000													28	186					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846452	43846452	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43846452G>A	ENST00000389420.3	-	13	1806	c.1807C>T	c.(1807-1809)Cga>Tga	p.R603*	ADAMTS20_ENST00000553158.1_Nonsense_Mutation_p.R603*	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	603	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TTACATGATCGAAATTTCATC	0.398000													9	17					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703333	55703333	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55703333C>T	ENST00000301532.3	-	1	543	c.544G>A	c.(544-546)Gac>Aac	p.D182N		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GGAGGGAGGTCACAGAAAAAA	0.403000													11	47					0	0	1	0	0
TRPV3	162514	broad.mit.edu	37	17	3430213	3430213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3430213G>A	ENST00000301365.4	-	12	1643	c.1512C>T	c.(1510-1512)gcC>gcT	p.A504A	TRPV3_ENST00000572519.1_Silent_p.A504A|TRPV3_ENST00000576742.1_Silent_p.A504A			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	504						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	GCAGGAAGATGGCAATGCCCT	0.567000													9	6					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25959211	25959211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25959211G>A	ENST00000356865.6	-	10	2065	c.1954C>T	c.(1954-1956)Ctc>Ttc	p.L652F		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	652					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TCCAGCCTGAGAAGCATGCCG	0.672000													14	46					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681681	55681681	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55681681G>A	ENST00000344514.1	-	1	377	c.378C>T	c.(376-378)atC>atT	p.I126I		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GGGGGTTGATGATGGCCTTGT	0.458000													29	49					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22945069	22945069	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22945069C>T	ENST00000313077.7	+	12	1265	c.1140C>T	c.(1138-1140)gcC>gcT	p.A380A	CYFIP1_ENST00000560848.1_Silent_p.A380A	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	380					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GCCAGGAGGCCCAGAAGACGG	0.701000													3	5					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990476	990476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:990476G>A	ENST00000190165.2	+	2	928	c.890G>A	c.(889-891)cGa>cAa	p.R297Q		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	297					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GGAGCAGAGCGAACTTCCGCA	0.582000													13	56					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551788	248551788	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248551788G>A	ENST00000355728.2	+	1	879	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGTCTGAGGAACAGGGATG	0.458000													13	59					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88847478	88847478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:88847478G>A	ENST00000333190.4	+	2	727	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	40						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GGATTTTGCAGAAAAGAAGTC	0.348000										HNSCC(36;0.09)			26	70					0	0	1	0	0
POLL	27343	broad.mit.edu	37	10	103339570	103339570	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103339570G>A	ENST00000370162.3	-	9	1862	c.1368C>T	c.(1366-1368)ttC>ttT	p.F456F	POLL_ENST00000370172.1_Silent_p.F368F|POLL_ENST00000370158.3_Silent_p.F181F|POLL_ENST00000299206.4_Silent_p.F456F|DPCD_ENST00000416979.2_Intron|POLL_ENST00000456836.2_Silent_p.F193F|POLL_ENST00000370168.3_Silent_p.F129F|POLL_ENST00000463515.1_5'UTR|POLL_ENST00000370169.1_Silent_p.F456F|DPCD_ENST00000470165.1_Intron|POLL_ENST00000339310.3_Silent_p.F179F	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	456					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		CATCTGTGAGGAACCCTGGCC	0.652000								DNA polymerases (catalytic subunits)					7	42					0	0	1	0	0
MAPK8IP1	9479	broad.mit.edu	37	11	45923603	45923603	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:45923603C>T	ENST00000395629.2	+	4	895	c.565C>T	c.(565-567)Ctg>Ttg	p.L189L	MAPK8IP1_ENST00000241014.2_Silent_p.L199L			Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting protein 1	199	JNK-binding domain (JBD).				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		ATCCTCACCCCTGAAGACAGG	0.532000													74	100					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59221646	59221646	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:59221646C>G	ENST00000262717.4	+	12	2522	c.2124C>G	c.(2122-2124)ctC>ctG	p.L708L	CDH20_ENST00000536675.2_Silent_p.L708L|CDH20_ENST00000538374.1_Silent_p.L708L			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	708					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TCGAGAGCCTCTCCCGCTACG	0.687000													14	51					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413782	48413782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48413782G>A	ENST00000249598.1	-	2	1245	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	362					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CAGCCAAGGGGAAGAAGCAGC	0.582000													19	51					0	0	1	0	0
NR4A1	3164	broad.mit.edu	37	12	52451238	52451238	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52451238C>T	ENST00000545748.1	+	7	2621	c.1626C>T	c.(1624-1626)gcC>gcT	p.A542A	NR4A1_ENST00000394824.2_Silent_p.A488A|NR4A1_ENST00000243050.1_Silent_p.A488A|NR4A1_ENST00000360284.3_Silent_p.A501A|NR4A1_ENST00000550082.1_Silent_p.A501A|NR4A1_ENST00000394825.1_Silent_p.A488A			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	488					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GTATCCTGGCCTTCTCAAGGT	0.612000													12	56					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155533028	155533028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155533028C>T	ENST00000404648.3	-	4	569	c.330G>A	c.(328-330)ttG>ttA	p.L110L	FGG_ENST00000407946.1_Silent_p.L110L|FGG_ENST00000336098.3_Silent_p.L110L|FGG_ENST00000405164.1_Silent_p.L110L	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	110					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TCCTGGACTTCAAAGTAGCAG	0.318000													9	31					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32089086	32089086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32089086G>A	ENST00000375201.4	-	6	554	c.509C>T	c.(508-510)tCc>tTc	p.S170F	ATF6B_ENST00000375203.3_Missense_Mutation_p.S173F			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	173					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						AGAGTTGACGGAAGAACATGG	0.537000													9	21					0	0	1	0	0
FAM53B	9679	broad.mit.edu	37	10	126370409	126370409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:126370409G>A	ENST00000337318.3	-	4	884	c.673C>T	c.(673-675)Ctg>Ttg	p.L225L	FAM53B_ENST00000392754.3_Silent_p.L225L|RP11-12J10.3_ENST00000494792.1_3'UTR|FAM53B_ENST00000280780.6_Silent_p.L225L	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	225										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		GACCGCTGCAGGTCCAGCCGG	0.642000													5	14					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702138	181702138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181702138G>A	ENST00000526775.1	+	19	3024	c.2859G>A	c.(2857-2859)acG>acA	p.T953T	CACNA1E_ENST00000367570.1_Silent_p.T972T|CACNA1E_ENST00000367567.4_Silent_p.T579T|CACNA1E_ENST00000360108.3_Silent_p.T953T|CACNA1E_ENST00000357570.5_Silent_p.T923T|CACNA1E_ENST00000358338.5_Silent_p.T904T|CACNA1E_ENST00000367573.2_Silent_p.T972T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	972					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.T972T(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGGAGCCAACGATCCAAGAAG	0.562000													10	33					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761127	92761127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92761127G>A	ENST00000318238.4	-	5	5374	c.4158C>T	c.(4156-4158)gcC>gcT	p.A1386A	SAMD9L_ENST00000411955.1_Silent_p.A1386A|SAMD9L_ENST00000437805.1_Silent_p.A1386A	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1386										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GAATAATGTTGGCCAAAATGG	0.383000													17	251					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493558	55493558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55493558G>A	ENST00000543010.1	+	6	635	c.492G>A	c.(490-492)ttG>ttA	p.L164L	NLRP2_ENST00000339757.7_Silent_p.L142L|NLRP2_ENST00000391721.4_Silent_p.L140L|NLRP2_ENST00000427260.2_Silent_p.L141L|NLRP2_ENST00000538819.1_Silent_p.L140L|NLRP2_ENST00000263437.6_Silent_p.L161L|NLRP2_ENST00000537859.1_Silent_p.L142L|NLRP2_ENST00000448584.2_Silent_p.L164L	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	164					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGTATATATTGAAGACGAAGT	0.453000													103	239					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115238117	115238117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115238117G>A	ENST00000369538.3	-	1	122	c.75C>T	c.(73-75)atC>atT	p.I25I	AMPD1_ENST00000353928.6_5'UTR|AMPD1_ENST00000520113.2_Silent_p.I25I	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	0					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TTGATTCTAGGATAGCACAGT	0.388000													39	141					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8174515	8174515	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8174515C>T	ENST00000600128.1	-	35	4870	c.4456_splice	c.e35+1	p.D1486_splice	FBN3_ENST00000601739.1_Splice_Site_p.D1486_splice|FBN3_ENST00000270509.2_Splice_Site_p.D1486_splice			Q75N90	FBN3_HUMAN	fibrillin 3	1486						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ATGGACTCACCCACGCAGCCC	0.567000													30	74					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24250784	24250784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24250784G>A	ENST00000256412.4	+	3	437	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	ADAMDEC1_ENST00000522298.1_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000538205.1_5'UTR	NM_014479.3	NP_055294.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	73					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		GGAAAGGTATGAACCTGAAGT	0.289000													25	71					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	47990456	47990456	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47990456G>A	ENST00000371741.4	-	2	1807	c.1641C>T	c.(1639-1641)acC>acT	p.T547T		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	547					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTGACTCCTTGGTATTGAGGA	0.517000													75	195					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723505	48723505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48723505C>T	ENST00000335017.1	+	1	743	c.431C>T	c.(430-432)cCc>cTc	p.P144L		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	144	Arg-rich.				chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						ACGCGCGCTCCCTGGAGGACC	0.721000													5	12					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77885578	77885578	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:77885578G>A	ENST00000354212.4	-	10	1982	c.1729C>T	c.(1729-1731)Cag>Tag	p.Q577*	MAGI2_ENST00000535697.1_Nonsense_Mutation_p.Q414*|MAGI2_ENST00000522391.1_Nonsense_Mutation_p.Q577*|MAGI2_ENST00000419488.1_Nonsense_Mutation_p.Q577*|MAGI2_ENST00000536571.1_Nonsense_Mutation_p.Q409*	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	577						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CCGTCTAGCTGACCATCAGTT	0.488000													16	41					0	0	1	0	0
C15orf32	145858	broad.mit.edu	37	15	93016251	93016251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93016251G>A	ENST00000333334.2	+	2	938	c.443G>A	c.(442-444)gGa>gAa	p.G148E	C15orf32_ENST00000556865.1_Missense_Mutation_p.G148E	NM_153040.2	NP_694585.1	Q32M92	CO032_HUMAN	chromosome 15 open reading frame 32	148										endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	12	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			TTCAATTGCGGAAGCATAGAG	0.468000													73	78					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101813497	101813497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101813497G>A	ENST00000506729.1	-	3	856	c.685C>T	c.(685-687)Ctg>Ttg	p.L229L	SLCO6A1_ENST00000514551.1_Intron|SLCO6A1_ENST00000379807.3_Silent_p.L229L|SLCO6A1_ENST00000379810.1_Intron|SLCO6A1_ENST00000389019.3_Intron|SLCO6A1_ENST00000513675.1_Intron			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	229						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AAGAAAGACAGGTATTTTGAT	0.363000													39	160					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046640	42046640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42046640G>A	ENST00000372584.1	-	3	4843	c.3829C>T	c.(3829-3831)Ccc>Tcc	p.P1277S	HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1277S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1277S|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1277S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1277					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TCTGTGCTGGGGGAGAGGCCA	0.617000													5	49					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52519592	52519592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52519592G>A	ENST00000270649.6	-	5	1803	c.1259C>T	c.(1258-1260)aCt>aTt	p.T420I	ZNF614_ENST00000356322.6_Intron	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	420					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TCCTGTATGAGTTCGCTGATG	0.413000													29	290					0	0	1	0	0
TPSG1	25823	broad.mit.edu	37	16	1272244	1272244	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1272244G>A	ENST00000234798.4	-	5	613	c.609C>T	c.(607-609)atC>atT	p.I203I		NM_012467.3	NP_036599.3	Q9NRR2	TRYG1_HUMAN	tryptase gamma 1	203	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			liver(1)|lung(2)|skin(1)	4		Hepatocellular(780;0.00369)				CGGGCTGAAGGATGCTGCCCC	0.706000													7	39					0	0	1	0	0
TNNI2	7136	broad.mit.edu	37	11	1862398	1862398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1862398G>A	ENST00000381906.1	+	7	483	c.414G>A	c.(412-414)agG>agA	p.R138R	TNNI2_ENST00000381905.3_Silent_p.R138R|TNNI2_ENST00000381911.1_Silent_p.R138R|TNNI2_ENST00000252898.7_Silent_p.R138R	NM_001145829.1	NP_001139301.1	P48788	TNNI2_HUMAN	troponin I type 2 (skeletal, fast)	138					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding			lung(8)|prostate(1)|urinary_tract(1)	10		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGACCTGAGGGCCAACCTGA	0.647000													19	29					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101606801	101606801	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101606801G>A	ENST00000370449.4	+	30	4343	c.4230G>A	c.(4228-4230)ttG>ttA	p.L1410L		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1410	ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGAAGGCCTTGGAGCTGGCTC	0.517000													63	183					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36940319	36940319	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36940319C>T	ENST00000262865.4	+	5	681	c.592C>T	c.(592-594)Cga>Tga	p.R198*	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	198					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				GTCTGCGCTTCGAAACAAGAT	0.507000													10	83					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360859	27360859	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27360859G>T	ENST00000335524.3	-	3	864	c.339C>A	c.(337-339)ccC>ccA	p.P113P		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	113	Pro-rich.									cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					agtggttggagggagaggatg	0.577000													5	17					0.014758	0.0147615	1	1	0
BHMT	635	broad.mit.edu	37	5	78415084	78415084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78415084C>T	ENST00000274353.5	+	3	276	c.169C>T	c.(169-171)Cgc>Tgc	p.R57C	DMGDH_ENST00000520388.1_Intron|BHMT_ENST00000524080.1_Intron	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	57	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	TCTCCCAGTTCGCCAGCTTCA	0.438000													30	100					0	0	1	0	0
NR6A1	2649	broad.mit.edu	37	9	127300526	127300526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127300526G>A	ENST00000487099.2	-	6	826	c.669C>T	c.(667-669)taC>taT	p.Y223Y	NR6A1_ENST00000373584.3_Silent_p.Y219Y|NR6A1_ENST00000416460.2_Silent_p.Y218Y|NR6A1_ENST00000344523.4_Silent_p.Y222Y	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	223	Sufficient for interaction with UIMC1 (By similarity).				cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						GTATATATTGGTAATGTGGAG	0.493000													23	66					0	0	1	0	0
PIGK	10026	broad.mit.edu	37	1	77620246	77620246	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:77620246G>A	ENST00000370812.3	-	9	897	c.874C>T	c.(874-876)Cag>Tag	p.Q292*	PIGK_ENST00000478391.1_5'UTR|PIGK_ENST00000359130.1_Nonsense_Mutation_p.Q292*|PIGK_ENST00000370813.5_Nonsense_Mutation_p.Q216*|PIGK_ENST00000445065.1_Nonsense_Mutation_p.Q198*	NM_005482.2	NP_005473.1	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class K	292					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	19						GGATCCCTCTGAAAAAGATCA	0.358000													19	61					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46916020	46916020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46916020C>T	ENST00000307522.3	-	1	821	c.48G>A	c.(46-48)gaG>gaA	p.E16E		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	16						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		ccagcctgacctcccggggga	0.602000													8	60					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692569	135692569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135692569G>A	ENST00000513104.1	-	2	789	c.507C>T	c.(505-507)atC>atT	p.I169I	TRPC7_ENST00000426057.2_Silent_p.I169I|TRPC7_ENST00000355180.3_Silent_p.I169I	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	169					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCGCCGCCAGGATGATGGGCG	0.632000													65	161					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382613	22382613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22382613C>T	ENST00000328795.4	+	1	232	c.141C>T	c.(139-141)ttC>ttT	p.F47F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCATTATTTTCACCATAAGGT	0.458000													78	231					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10357980	10357980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10357980C>T	ENST00000255381.2	-	22	2693	c.2583G>A	c.(2581-2583)gaG>gaA	p.E861E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	861					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CTTTGGTTTTCTCAAATTCTT	0.438000													40	100					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53340208	53340208	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:53340208C>T	ENST00000566029.1	+	32	6888	c.6679C>T	c.(6679-6681)Cag>Tag	p.Q2227*	CHD9_ENST00000447540.1_Nonsense_Mutation_p.Q2228*|CHD9_ENST00000398510.3_Nonsense_Mutation_p.Q2227*|CHD9_ENST00000564845.1_Nonsense_Mutation_p.Q2227*			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2227					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GAGCACTACCCAGGATGAGAC	0.398000													25	48					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121440964	121440964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121440964G>A	ENST00000260197.7	+	23	3451	c.3322G>A	c.(3322-3324)Gat>Aat	p.D1108N	SORL1_ENST00000525532.1_Missense_Mutation_p.D52N	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1108	LDL-receptor class A 1.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGACATGAGCGATGAGAGAAA	0.507000													34	83					0	0	1	0	0
ZNF839	55778	broad.mit.edu	37	14	102802155	102802155	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102802155C>T	ENST00000262236.5	+	5	1646	c.1291C>T	c.(1291-1293)Ctg>Ttg	p.L431L	ZNF839_ENST00000559185.1_Silent_p.L431L|ZNF839_ENST00000442396.2_Silent_p.L547L|ZNF839_ENST00000558850.1_Silent_p.L431L	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	431						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CCAGGAGACCCTGGAAATAAA	0.413000													20	40					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71510360	71510360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71510360C>T	ENST00000396073.3	+	9	3498	c.3217C>T	c.(3217-3219)Cca>Tca	p.P1073S	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	1073					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			CACCGGAACTCCATCTAGCGA	0.433000													21	95					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70488360	70488360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70488360G>A	ENST00000260128.4	+	6	1045	c.328G>A	c.(328-330)Gag>Aag	p.E110K	SULF1_ENST00000419716.3_Missense_Mutation_p.E110K|SULF1_ENST00000458141.2_Missense_Mutation_p.E110K|SULF1_ENST00000402687.4_Missense_Mutation_p.E110K	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	110					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CACCAACAACGAGAACTGCTC	0.507000													13	61					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173679074	173679074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:173679074C>T	ENST00000264111.6	+	4	552	c.365C>T	c.(364-366)cCc>cTc	p.P122L	RAPGEF4_ENST00000397081.3_Missense_Mutation_p.P122L|RAPGEF4_ENST00000409036.1_Missense_Mutation_p.P122L			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	122					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GACAACACACCCCGCCATGCA	0.517000													38	94					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751521	140751521	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140751521C>T	ENST00000576222.1	+	1	1691	c.1560C>T	c.(1558-1560)ttC>ttT	p.F520F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGAGCCTTCGACCACGAGC	0.682000													8	70					0	0	1	0	0
TLDC1	57707	broad.mit.edu	37	16	84520383	84520383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84520383G>A	ENST00000343629.6	-	5	994	c.812C>T	c.(811-813)tCg>tTg	p.S271L	TLDC1_ENST00000535580.1_Missense_Mutation_p.S244L	NM_020947.3	NP_065998.3			TBC/LysM-associated domain containing 1																		GAGCTCAGACGAAAAGAGCAG	0.597000													18	37					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121944316	121944316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121944316C>T	ENST00000442488.2	-	1	243	c.176G>A	c.(175-177)gGg>gAg	p.G59E	FEZF1-AS1_ENST00000428449.1_RNA|FEZF1_ENST00000331178.4_Missense_Mutation_p.G59E|FEZF1_ENST00000427185.2_Missense_Mutation_p.G59E	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	59					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						CTTGGGTTCCCCCTTGGGTAA	0.617000													36	109					0	0	1	0	0
NAT6	24142	broad.mit.edu	37	3	50334496	50334496	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50334496G>A	ENST00000443842.1	-	2	1206	c.399C>T	c.(397-399)ccC>ccT	p.P133P	HYAL3_ENST00000415204.1_Intron|HYAL3_ENST00000359051.3_Intron|HYAL3_ENST00000336307.1_Intron|NAT6_ENST00000443094.2_Silent_p.P133P|NAT6_ENST00000354862.4_Silent_p.P155P|NAT6_ENST00000417393.1_Silent_p.P133P|HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000450982.1_Intron					N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		AGAGGCTCTGGGGCTGGTTCA	0.682000													7	18					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27528496	27528496	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27528496G>A	ENST00000296098.4	+	6	1050	c.780G>A	c.(778-780)gaG>gaA	p.E260E	TRIM54_ENST00000380075.2_Silent_p.E218E	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	218					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAGGTTTGAGAGCCTGTGCG	0.627000													13	13					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171154906	171154906	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171154906G>A	ENST00000441535.1	+	2	171	c.54G>A	c.(52-54)ctG>ctA	p.L18L	FMO2_ENST00000529935.1_Intron|RP1-45C12.1_ENST00000455124.1_RNA|FMO2_ENST00000209929.7_Silent_p.L18L	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	18					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TAATTTCTCTGAAGTGCTGTG	0.463000													57	160					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26619945	26619945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26619945G>A	ENST00000256737.3	+	15	2333	c.1481G>A	c.(1480-1482)aGg>aAg	p.R494K	ANO3_ENST00000537978.1_Missense_Mutation_p.R478K|ANO3_ENST00000525139.1_Missense_Mutation_p.R478K|ANO3_ENST00000531568.1_Missense_Mutation_p.R348K	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	494						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						AAAAGGAGAAGGAGTATACTG	0.353000													10	119					0	0	1	0	0
ADCK4	79934	broad.mit.edu	37	19	41209632	41209632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41209632G>A	ENST00000324464.3	-	8	1006	c.705C>T	c.(703-705)gcC>gcT	p.A235A	ADCK4_ENST00000450541.1_Silent_p.A194A|ADCK4_ENST00000243583.6_Silent_p.A194A	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	235	Protein kinase.					integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GGATCTTCACGGCCACCTCCG	0.657000													15	69					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17596843	17596843	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17596843C>T	ENST00000375460.3	+	7	808	c.768C>T	c.(766-768)ttC>ttT	p.F256F		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	256					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GCCTGTCCTTCCCTGATGCCG	0.582000													31	65					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47765403	47765403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47765403C>T	ENST00000273857.4	-	4	609	c.610G>A	c.(610-612)Gat>Aat	p.D204N	CORIN_ENST00000504584.1_Missense_Mutation_p.D204N|CORIN_ENST00000502252.1_Missense_Mutation_p.D137N|CORIN_ENST00000505909.1_Missense_Mutation_p.D204N|CORIN_ENST00000508498.1_Missense_Mutation_p.D65N	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	204	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TACCTGTCATCGCCATCAATG	0.413000													6	17					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258362	56258362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56258362G>A	ENST00000327216.2	-	1	509	c.485C>T	c.(484-486)aCc>aTc	p.T162I		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					TAGGTTGTAGGTCCACATGGT	0.507000													32	103					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489440	237489440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:237489440C>T	ENST00000272928.3	+	2	642	c.332C>T	c.(331-333)cCc>cTc	p.P111L		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		AACCAGTGGCCCATGGGCGAG	0.572000													29	107					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144060402	144060402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:144060402G>A	ENST00000056217.5	+	2	814	c.640G>A	c.(640-642)Gag>Aag	p.E214K		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	214					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					GCCACCTGAGGAGCTGCAGGA	0.557000													46	218					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18378199	18378199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18378199G>A	ENST00000392413.3	-	3	366	c.151C>T	c.(151-153)Cct>Tct	p.P51S	KIAA1683_ENST00000600328.2_Missense_Mutation_p.P51S|KIAA1683_ENST00000600359.2_Missense_Mutation_p.P5S	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	51						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GGCTGTGGAGGCGCTTTCTCC	0.667000													48	107					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21631030	21631030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21631030G>A	ENST00000328843.6	+	14	2533	c.2502G>A	c.(2500-2502)gtG>gtA	p.V834V	DNAH11_ENST00000409508.3_Silent_p.V834V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	834	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGAAAAACGTGAAGGTGATCC	0.607000									Kartagener syndrome				21	56					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136562339	136562339	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136562339G>A	ENST00000264162.2	-	10	4472	c.4462C>T	c.(4462-4464)Cag>Tag	p.Q1488*		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1488	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CACCATACCTGGGGCTGGATG	0.547000													15	33					0	0	1	0	0
TNFRSF10B	8795	broad.mit.edu	37	8	22926370	22926370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22926370C>T	ENST00000276431.4	-	1	322	c.38G>A	c.(37-39)gGg>gAg	p.G13E	TNFRSF10B_ENST00000347739.3_Missense_Mutation_p.G13E|RP11-875O11.2_ENST00000501897.1_RNA|TNFRSF10B_ENST00000542226.1_5'UTR	NM_003842.4|NM_147187.2	NP_003833.4|NP_671716.2	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily, member 10b	13					activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding			NS(1)|endometrium(2)|large_intestine(7)|liver(1)|lung(3)|skin(1)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		TTTCCGGGCCCCCGAAGCGGC	0.677000													23	33					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78069181	78069181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78069181G>A	ENST00000397545.4	+	18	2979	c.2952G>A	c.(2950-2952)aaG>aaA	p.K984K		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	984					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGGACAGGAAGGCGCTCACCC	0.627000													22	55					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64417930	64417930	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64417930G>A	ENST00000265459.6	-	15	3560	c.3099C>T	c.(3097-3099)ctC>ctT	p.L1033L	NRXN2_ENST00000377551.1_Silent_p.L1033L|AP001092.4_ENST00000433606.1_RNA|NRXN2_ENST00000409571.1_Silent_p.L1026L|NRXN2_ENST00000377559.3_Silent_p.L993L	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1033	Laminin G-like 5.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CTTTGAGATCGAGGTTTCGGG	0.632000													36	137					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119540121	119540121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119540121C>T	ENST00000267260.4	+	2	600	c.212C>T	c.(211-213)cCc>cTc	p.P71L	RP11-364C11.2_ENST00000537730.1_RNA	NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	71					cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						GCCACCGAGCCCTTGGGCACC	0.542000													9	32					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81864696	81864696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81864696G>A	ENST00000555447.1	-	3	443	c.31C>T	c.(31-33)Cac>Tac	p.H11Y	STON2_ENST00000267540.2_Missense_Mutation_p.H11Y	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	11					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TCTGACTGGTGGGTGGCAATC	0.517000													18	50					0	0	1	0	0
C1orf146	388649	broad.mit.edu	37	1	92707838	92707838	+	Missense_Mutation	SNP	G	G	A	rs41286799		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92707838G>A	ENST00000370375.3	+	3	284	c.136G>A	c.(136-138)Gga>Aga	p.G46R	C1orf146_ENST00000370373.2_5'UTR	NM_001012425.1	NP_001012425.1	Q5VVC0	CA146_HUMAN	chromosome 1 open reading frame 146	46										breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		AGTGGAAAATGGATCAATTAT	0.299000													12	48					0	0	1	0	0
NOL10	79954	broad.mit.edu	37	2	10712207	10712207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:10712207G>A	ENST00000345985.3	-	20	2017	c.1907C>T	c.(1906-1908)tCg>tTg	p.S636L	NOL10_ENST00000538384.1_Missense_Mutation_p.S660L|NOL10_ENST00000542668.1_Missense_Mutation_p.S636L|NOL10_ENST00000381685.5_Missense_Mutation_p.S686L	NM_001261394.1	NP_001248323.1	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	686						nucleolus						Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		TCAATGAAACGACCGTCCTCT	0.498000													67	166					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53572226	53572226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53572226G>A	ENST00000601421.1	-	3	2329	c.1453C>T	c.(1453-1455)Cgt>Tgt	p.R485C	ZNF160_ENST00000418871.1_Missense_Mutation_p.R521C|ZNF160_ENST00000599056.1_Missense_Mutation_p.R521C|ZNF160_ENST00000429604.1_Missense_Mutation_p.R521C			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	521					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R521C(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		AGACTTGAACGAACACTGAAG	0.398000													16	148					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416282	178416282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178416282G>A	ENST00000231188.5	-	5	1315	c.1137C>T	c.(1135-1137)tcC>tcT	p.S379S	GRM6_ENST00000517717.1_Silent_p.S379S|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	379					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		ATTTGCGGGTGGAATCGTCTG	0.612000													21	36					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61828486	61828486	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61828486C>T	ENST00000280772.1	-	37	12344	c.12153G>A	c.(12151-12153)acG>acA	p.T4051T	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4051					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TAGCAGACTTCGTTGTAACCG	0.478000													66	166					0	0	1	0	0
PGD	5226	broad.mit.edu	37	1	10477453	10477453	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10477453C>T	ENST00000538557.1	+	10	1201	c.957C>T	c.(955-957)atC>atT	p.I319I	PGD_ENST00000270776.8_Silent_p.I332I|PGD_ENST00000541529.1_Silent_p.I310I|PGD_ENST00000498356.1_3'UTR			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	332					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		CTTCCAAGATCATCTCTTACG	0.507000													71	188					0	0	1	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148748050	148748050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148748050C>T	ENST00000514349.1	+	5	1627	c.1048C>T	c.(1048-1050)Cat>Tat	p.H350Y	PCYOX1L_ENST00000274569.4_Missense_Mutation_p.H440Y			Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like	440					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			breast(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTGCACTCCATGACCAGCT	0.607000													29	78					0	0	1	0	0
NEK9	91754	broad.mit.edu	37	14	75563921	75563921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75563921G>A	ENST00000238616.5	-	17	2213	c.2055C>T	c.(2053-2055)acC>acT	p.T685T		NM_033116.4	NP_149107.4	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	685					cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00718)		TCTCTGTGGGGGTCATTGCCA	0.498000													23	39					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23285498	23285498	+	RNA	SNP	T	T	A	rs116993237	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23285498T>A	ENST00000560464.1	-	0	5097																											CGTCACAGTGTGCGTGCTTGT	0.572000													4	42					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3227866	3227866	+	Missense_Mutation	SNP	C	C	T	rs149129110		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3227866C>T	ENST00000217939.6	-	7	8532	c.8378G>A	c.(8377-8379)gGa>gAa	p.G2793E		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2793	Ig-like C2-type 12.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGTCAGTGATCCCTGGGGGTG	0.502000													25	14					0	0	1	0	0
SLC47A1	55244	broad.mit.edu	37	17	19480671	19480671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:19480671G>A	ENST00000270570.4	+	17	1604	c.1518G>A	c.(1516-1518)acG>acA	p.T506T	SLC47A1_ENST00000436810.2_3'UTR|RP11-1113L8.1_ENST00000574267.1_RNA|SLC47A1_ENST00000571335.1_Silent_p.T252T|SLC47A1_ENST00000575023.1_Silent_p.T204T|SLC47A1_ENST00000457293.1_Silent_p.T506T|SLC47A1_ENST00000395585.1_Silent_p.T506T	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	506						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					GAATTTTAACGAACGATGTTG	0.443000													22	60					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85997426	85997426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85997426C>T	ENST00000372105.3	-	2	160	c.139G>A	c.(139-141)Gac>Aac	p.D47N		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	47	LRRNT.					integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						ATGTCGGGGTCGTTGCACACT	0.657000													17	55					0	0	1	0	0
MRPS35	60488	broad.mit.edu	37	12	27872744	27872744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:27872744C>T	ENST00000081029.3	+	4	396	c.325C>T	c.(325-327)Ccc>Tcc	p.P109S	MRPS35_ENST00000538315.1_Missense_Mutation_p.P109S	NM_021821.3	NP_068593.2	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35	109					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit				breast(1)|endometrium(1)|kidney(1)|lung(2)|urinary_tract(1)	6	Lung SC(9;0.0873)					ATTTAAGATTCCCAATTTTCT	0.274000													15	67					0	0	1	0	0
ZFP3	124961	broad.mit.edu	37	17	4995352	4995352	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4995352C>T	ENST00000318833.3	+	2	889	c.553C>T	c.(553-555)Cga>Tga	p.R185*		NM_153018.2	NP_694563.1	Q96NJ6	ZFP3_HUMAN	ZFP3 zinc finger protein	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(3)|prostate(1)	20						TTCAAGCCTTCGACGGCACCT	0.398000													49	50					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9117527	9117527	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9117527G>A	ENST00000377424.4	-	3	452	c.273C>T	c.(271-273)ccC>ccT	p.P91P	SLC2A5_ENST00000377414.3_Silent_p.P91P|SLC2A5_ENST00000535586.1_Intron	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	91					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TATTCACCAAGGGGCCGACCA	0.473000													19	33					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17462538	17462538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:17462538G>A	ENST00000262545.2	+	12	2055	c.1740G>A	c.(1738-1740)caG>caA	p.Q580Q	PCSK2_ENST00000536609.1_Silent_p.Q545Q|PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000377899.1_Silent_p.Q561Q	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	580					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCGCCCCGCAGAAGGGGGTGC	0.617000													9	28					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59203811	59203811	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:59203811G>A	ENST00000262717.4	+	8	1755	c.1357G>A	c.(1357-1359)Gac>Aac	p.D453N	CDH20_ENST00000536675.2_Missense_Mutation_p.D453N|CDH20_ENST00000538374.1_Missense_Mutation_p.D453N			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	453	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				AAGACCCCTAGACCGGGAAGA	0.418000													56	135					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181539	140181539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140181539G>A	ENST00000522353.2	+	1	757	c.757G>A	c.(757-759)Gaa>Aaa	p.E253K	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.E253K|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATTACTCGAAAATGCACC	0.443000													24	53					0	0	1	0	0
MYL9	10398	broad.mit.edu	37	20	35177519	35177519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35177519C>T	ENST00000279022.2	+	4	490	c.386C>T	c.(385-387)aCc>aTc	p.T129I	MYL9_ENST00000346786.2_Missense_Mutation_p.T75I|RP5-977B1.7_ENST00000439595.1_RNA|RP5-977B1.7_ENST00000425233.1_RNA	NM_006097.4	NP_006088.2	P24844	MYL9_HUMAN	myosin, light chain 9, regulatory	129	EF-hand 2.				axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)	8	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CTGCTCACCACCATGGGTGAC	0.582000													23	60					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44890982	44890982	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44890982C>T	ENST00000330997.4	-	4	1489	c.1425G>A	c.(1423-1425)caG>caA	p.Q475Q	ZNF285_ENST00000591679.1_Silent_p.Q482Q|CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000544719.2_Silent_p.Q475Q	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						TGTGAACTCTCTGATGAGTGT	0.403000													13	97					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113508735	113508735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113508735G>A	ENST00000505019.1	-	12	3603	c.3478C>T	c.(3478-3480)Cca>Tca	p.P1160S		NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	0										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ACTCTGTTTGGAGTAGCCACG	0.408000													87	155					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427635	119427635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119427635G>A	ENST00000369429.3	-	8	1538	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F	TBX15_ENST00000207157.3_Missense_Mutation_p.S404F			Q96SF7	TBX15_HUMAN	T-box 15	510						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GTTGTGAAGGGAGAAGGCATT	0.527000													20	35					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61822884	61822884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61822884G>A	ENST00000280772.1	-	40	12771	c.12580C>T	c.(12580-12582)Cat>Tat	p.H4194Y	ANK3_ENST00000355288.2_Missense_Mutation_p.H715Y|ANK3_ENST00000503366.1_Missense_Mutation_p.H1582Y|ANK3_ENST00000373827.2_Missense_Mutation_p.H1575Y	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4194					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACAGGGTCATGGAAAACATTG	0.328000													8	27					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250110	140250110	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140250110C>T	ENST00000398640.2	+	1	1422	c.1422C>T	c.(1420-1422)ttC>ttT	p.F474F	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACATCTTCACAGTGTCGG	0.662000													58	139					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88476372	88476372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88476372C>T	ENST00000394480.1	-	16	2081	c.1760G>A	c.(1759-1761)aGg>aAg	p.R587K	NTRK3_ENST00000542733.2_Missense_Mutation_p.R489K|NTRK3_ENST00000355254.2_Missense_Mutation_p.R587K|NTRK3_ENST00000357724.2_Missense_Mutation_p.R579K|NTRK3_ENST00000558676.1_Missense_Mutation_p.R579K|NTRK3_ENST00000360948.2_Missense_Mutation_p.R587K|NTRK3_ENST00000557856.1_Missense_Mutation_p.R579K	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	587	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTCGGCCTCCCTCTGGAAATC	0.552000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			6	90					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30024717	30024717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:30024717G>A	ENST00000346128.6	-	15	2411	c.1937C>T	c.(1936-1938)cCt>cTt	p.P646L	TJP1_ENST00000400011.2_Missense_Mutation_p.P650L|TJP1_ENST00000545208.2_Missense_Mutation_p.P646L|TJP1_ENST00000356107.6_Missense_Mutation_p.P646L	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	646	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		AATGGTTACAGGCCTCAGAAA	0.368000													19	83					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204913519	204913519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204913519G>A	ENST00000367172.4	+	3	404	c.76G>A	c.(76-78)Gaa>Aaa	p.E26K	NFASC_ENST00000513543.1_Missense_Mutation_p.E26K|NFASC_ENST00000338586.6_Missense_Mutation_p.E26K|NFASC_ENST00000367169.4_Missense_Mutation_p.E26K|NFASC_ENST00000360049.4_Missense_Mutation_p.E26K|NFASC_ENST00000367171.4_Missense_Mutation_p.E26K|NFASC_ENST00000401399.1_Missense_Mutation_p.E26K|NFASC_ENST00000539706.1_Missense_Mutation_p.E26K|NFASC_ENST00000403080.1_Missense_Mutation_p.E26K|NFASC_ENST00000367170.4_Missense_Mutation_p.E26K|NFASC_ENST00000339876.6_Missense_Mutation_p.E26K|NFASC_ENST00000404907.1_Missense_Mutation_p.E26K|NFASC_ENST00000404076.1_Missense_Mutation_p.E26K|NFASC_ENST00000338515.6_Missense_Mutation_p.E26K			O94856	NFASC_HUMAN	neurofascin	26					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.E26K(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CGGAGCCATCGAAATTCCTAT	0.597000													7	20					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55280655	55280655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55280655C>T	ENST00000358193.3	+	8	1047	c.993C>T	c.(991-993)ttC>ttT	p.F331F	C1orf177_ENST00000371273.3_Silent_p.F331F	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	331										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						AGCCCCCATTCCTGTTGACCT	0.542000													50	115					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109271457	109271457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109271457G>A	ENST00000370017.3	+	8	1850	c.1573G>A	c.(1573-1575)Gaa>Aaa	p.E525K	FNDC7_ENST00000271311.2_Missense_Mutation_p.E526K	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	526	Fibronectin type-III 6.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TGCTGTGGCCGAAACACAGGC	0.577000													24	52					0	0	1	0	0
SPINK4	27290	broad.mit.edu	37	9	33246683	33246683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33246683G>A	ENST00000379725.1	+	4	363	c.241G>A	c.(241-243)Ggg>Agg	p.G81R	SPINK4_ENST00000379723.1_Missense_Mutation_p.G81R|SPINK4_ENST00000379721.3_Missense_Mutation_p.G58R			O60575	ISK4_HUMAN	serine peptidase inhibitor, Kazal type 4	58	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			lung(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			CGGCACTGATGGGCTCACATA	0.567000													23	52					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7714547	7714547	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:7714547G>A	ENST00000507866.2	+	15	2065	c.1956G>A	c.(1954-1956)gaG>gaA	p.E652E	SORCS2_ENST00000329016.9_Silent_p.E480E	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	652						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						GCGGCGAGGAGGACTACAGCT	0.637000													11	22					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43813609	43813609	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43813609G>A	ENST00000382031.1	+	5	683	c.652G>A	c.(652-654)Gga>Aga	p.G218R	MAP1A_ENST00000399453.1_5'UTR|MAP1A_ENST00000300231.5_5'UTR			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	0						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GAGCCACCTGGGATTATCCAG	0.547000													16	81					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69969797	69969797	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:69969797C>T	ENST00000359154.2	+	18	1985	c.1884C>T	c.(1882-1884)ctC>ctT	p.L628L	WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000568684.1_Silent_p.L189L|WWP2_ENST00000542271.1_Silent_p.L512L|WWP2_ENST00000448661.1_Silent_p.L628L|WWP2_ENST00000356003.2_Silent_p.L628L	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	628	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCTTCACCCTCCCTTTCTACA	0.532000													55	164					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28617391	28617391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28617391G>A	ENST00000395609.1	-	9	1519	c.761C>T	c.(760-762)cCc>cTc	p.P254L	SULT1A1_ENST00000350842.4_Missense_Mutation_p.P176L|SULT1A1_ENST00000395607.1_Missense_Mutation_p.P254L|SULT1A1_ENST00000569554.1_Missense_Mutation_p.P254L|SULT1A1_ENST00000314752.7_Missense_Mutation_p.P254L			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	254					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						CCTCATGAAGGGGGAGATGCT	0.607000													47	199					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99315203	99315203	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99315203C>T	ENST00000336374.2	-	5	380	c.378G>A	c.(376-378)tgG>tgA	p.W126*		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	126					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					GTATTCTCTTCCATTCTTCAT	0.383000													6	63					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28467325	28467325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28467325G>A	ENST00000261609.7	-	36	5609	c.5501C>T	c.(5500-5502)gCt>gTt	p.A1834V		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1834					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTGAGCAGAAGCATTCATATC	0.493000													16	57					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20024478	20024478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:20024478C>T	ENST00000400230.2	-	12	853	c.809G>A	c.(808-810)aGa>aAa	p.R270K	TPTE2_ENST00000457266.2_Missense_Mutation_p.R159K|TPTE2_ENST00000390680.2_Missense_Mutation_p.R193K|TPTE2_ENST00000400103.2_Missense_Mutation_p.R159K|TPTE2_ENST00000255310.6_Missense_Mutation_p.R193K|TPTE2_ENST00000382977.4_Missense_Mutation_p.R270K|TPTE2_ENST00000382978.1_Missense_Mutation_p.R230K|TPTE2_ENST00000382975.4_Missense_Mutation_p.R230K			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	270	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATCATAAGCTCTTTCACCTAA	0.294000													33	87					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33991943	33991943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33991943C>T	ENST00000389232.4	+	41	6358	c.6288C>T	c.(6286-6288)ttC>ttT	p.F2096F	RYR3_ENST00000415757.3_Silent_p.F2096F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2096	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTGCCGTTTCCTTTGCTATT	0.438000													7	29					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74876271	74876271	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74876271G>A	ENST00000331628.3	-	2	424	c.177C>T	c.(175-177)tcC>tcT	p.S59S	SYNDIG1L_ENST00000554823.1_Silent_p.S59S	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	59					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						CCAGCTGCAGGGACCCTGGGT	0.672000													8	28					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155486959	155486959	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155486959G>A	ENST00000302068.4	+	2	177		c.e2-1		FGB_ENST00000502545.1_Splice_Site|FGB_ENST00000509493.1_Intron	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain						platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	ATTCCTTGTAGGGTTTCTTCA	0.463000													12	29					0	0	1	0	0
CH25H	9023	broad.mit.edu	37	10	90966300	90966300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90966300G>A	ENST00000371852.2	-	1	771	c.750C>T	c.(748-750)ttC>ttT	p.F250F		NM_003956.3	NP_003947.1	O95992	CH25H_HUMAN	cholesterol 25-hydroxylase	250					bile acid biosynthetic process|fatty acid biosynthetic process|sterol biosynthetic process	cytosol|endoplasmic reticulum membrane|integral to membrane	cholesterol 25-hydroxylase activity|iron ion binding			kidney(1)|large_intestine(2)|lung(3)|stomach(1)	7		Colorectal(252;0.0161)		GBM - Glioblastoma multiforme(2;0.000133)		AGTACGGAGCGAAGTTGCAGT	0.582000													19	16					0	0	1	0	0
WNT5A	7474	broad.mit.edu	37	3	55504313	55504313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:55504313G>A	ENST00000474267.1	-	6	1471	c.950C>T	c.(949-951)tCg>tTg	p.S317L	WNT5A_ENST00000497027.1_Missense_Mutation_p.S302L|WNT5A_ENST00000264634.4_Missense_Mutation_p.S317L			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	317					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		CGTGCCCAGCGAGCCGGTGCT	0.627000													18	44					0	0	1	0	0
TANGO2	128989	broad.mit.edu	37	22	20049180	20049180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20049180C>T	ENST00000327374.4	+	7	757	c.579C>T	c.(577-579)ctC>ctT	p.L193L	TANGO2_ENST00000432883.1_Silent_p.L131L|TANGO2_ENST00000447208.2_Silent_p.L193L|TANGO2_ENST00000420290.2_Silent_p.L95L|TANGO2_ENST00000434570.2_Intron|TANGO2_ENST00000401886.1_Silent_p.L131L|TANGO2_ENST00000401833.1_Silent_p.L234L|TANGO2_ENST00000456048.1_Silent_p.L198L|TANGO2_ENST00000398042.2_Silent_p.L131L	NM_152906.4	NP_690870.3			transport and golgi organization 2 homolog (Drosophila)																		TCGCCAGCCTCCTGGATGTGC	0.642000													3	8					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161044144	161044144	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161044144C>T	ENST00000368012.3	-	6	1322	c.1020G>A	c.(1018-1020)ggG>ggA	p.G340G	PVRL4_ENST00000453926.2_Silent_p.G74G	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	340					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CCACCTGCTTCCCAGAGTCTT	0.612000													28	57					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74041116	74041116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74041116C>T	ENST00000409561.1	+	2	731	c.610C>T	c.(610-612)Ccc>Tcc	p.P204S		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	204										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						CCTGTCACTTCCCTGCCAGAT	0.473000													23	46					0	0	1	0	0
COPB1	1315	broad.mit.edu	37	11	14504625	14504625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:14504625G>A	ENST00000249923.3	-	8	1210	c.910C>T	c.(910-912)Cgc>Tgc	p.R304C	COPB1_ENST00000439561.2_Missense_Mutation_p.R304C	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	304					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						TCTATCAAGCGATCCAAAACT	0.308000													19	45					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367521	107367521	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107367521G>A	ENST00000542196.1	-	1	430	c.388C>T	c.(388-390)Ctg>Ttg	p.L130L		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						GGATATCTCAGAGGGTTGCAG	0.512000													9	139					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108385508	108385508	+	Silent	SNP	G	G	A	rs116742815	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108385508G>A	ENST00000265843.4	-	6	836	c.726C>T	c.(724-726)ttC>ttT	p.F242F	EXPH5_ENST00000428840.1_Silent_p.F166F|EXPH5_ENST00000443411.1_Silent_p.F54F|EXPH5_ENST00000524840.1_5'UTR|EXPH5_ENST00000525344.1_Silent_p.F235F	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	242					intracellular protein transport		Rab GTPase binding	p.F242F(1)		breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AAAAGTGACCGAACTGTGTTC	0.383000													50	115					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40399472	40399472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:40399472C>T	ENST00000338305.6	-	2	1923	c.1381G>A	c.(1381-1383)Gat>Aat	p.D461N		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	461	Fibronectin type-III.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGTACCTCATCGTCAGAGCAG	0.592000													21	50					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25326366	25326366	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25326366C>T	ENST00000546682.1	+	0	66				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TGGGATCCTCCTGGATGTAAG	0.488000													18	38					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157085	22157085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22157085G>A	ENST00000397126.4	-	4	899	c.751C>T	c.(751-753)Cat>Tat	p.H251Y	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTCCAGTATGAATTACCTTA	0.353000													24	47					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684591	100684591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100684591G>A	ENST00000306151.4	+	3	9958	c.9894G>A	c.(9892-9894)acG>acA	p.T3298T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3298	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTTCTGAAACGAGCACCCTTT	0.507000													252	514					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42122179	42122179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42122179C>T	ENST00000502486.1	-	5	1858	c.1279G>A	c.(1279-1281)Gag>Aag	p.E427K	BEND4_ENST00000504360.1_Missense_Mutation_p.E423K	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	427	BEN.									NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						TACTTAAGCTCATCGGTTGTG	0.468000													6	49					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54403940	54403940	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54403940G>A	ENST00000263431.3	+	14	1794	c.1512G>A	c.(1510-1512)gaG>gaA	p.E504E	PRKCG_ENST00000540413.1_Silent_p.E504E|PRKCG_ENST00000542049.1_Silent_p.E391E	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	504	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TGTGTAAGGAGAACGTCTTCC	0.587000													90	361					0	0	1	0	0
ACKR2	1238	broad.mit.edu	37	3	42906678	42906678	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42906678C>T	ENST00000422265.1	+	3	859	c.684C>T	c.(682-684)ttC>ttT	p.F228F	ACKR2_ENST00000471537.1_Intron|ACKR2_ENST00000273145.2_Silent_p.F228F|ACKR2_ENST00000442925.1_Silent_p.F228F|CYP8B1_ENST00000437102.1_Intron|KRBOX1_ENST00000426937.1_Intron	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		CCATGATCTTCTTCTACTCCC	0.572000													84	164					0	0	1	0	0
USH1G	124590	broad.mit.edu	37	17	72916336	72916336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72916336G>A	ENST00000319642.1	-	2	777	c.595C>T	c.(595-597)Ctg>Ttg	p.L199L		NM_173477.2	NP_775748.2	Q495M9	USH1G_HUMAN	Usher syndrome 1G (autosomal recessive)	199					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton			HN1/USH1G(2)	endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(3)	14	all_lung(278;0.172)|Lung NSC(278;0.207)					GAGTACGGCAGGTGGCTGCCC	0.687000													16	43					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840247	27840247	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27840247G>A	ENST00000356790.2	+	3	1069	c.824G>A	c.(823-825)tGg>tAg	p.W275*		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	275	MAGE.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						CAATTCCTATGGGGCCCAAGA	0.468000													22	14					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52901800	52901800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52901800G>A	ENST00000354452.3	-	16	2076	c.1465C>T	c.(1465-1467)Cca>Tca	p.P489S	TCF4_ENST00000457482.3_Missense_Mutation_p.P329S|TCF4_ENST00000566279.1_Missense_Mutation_p.P429S|TCF4_ENST00000543082.1_Missense_Mutation_p.P447S|TCF4_ENST00000540999.1_Missense_Mutation_p.P465S|TCF4_ENST00000537856.3_Missense_Mutation_p.P359S|TCF4_ENST00000544241.2_Missense_Mutation_p.P418S|TCF4_ENST00000570287.2_Missense_Mutation_p.P329S|TCF4_ENST00000564403.2_Missense_Mutation_p.P495S|TCF4_ENST00000570177.2_Missense_Mutation_p.P359S|TCF4_ENST00000568740.1_Missense_Mutation_p.P464S|TCF4_ENST00000564228.1_Missense_Mutation_p.P418S|TCF4_ENST00000537578.1_Missense_Mutation_p.P465S|TCF4_ENST00000565018.2_Missense_Mutation_p.P489S|TCF4_ENST00000356073.4_Missense_Mutation_p.P489S|TCF4_ENST00000564999.1_Missense_Mutation_p.P489S|TCF4_ENST00000561992.1_Missense_Mutation_p.P359S|TCF4_ENST00000398339.1_Missense_Mutation_p.P591S|TCF4_ENST00000561831.3_Missense_Mutation_p.P329S|TCF4_ENST00000568673.1_Missense_Mutation_p.P465S|TCF4_ENST00000566286.1_Missense_Mutation_p.P486S|TCF4_ENST00000567880.1_Missense_Mutation_p.P429S	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	489					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TCCTGGGGTGGGTTCAGGTCA	0.562000											OREG0024990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	81					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7830111	7830111	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7830111C>T	ENST00000327325.5	+	3	289	c.171C>T	c.(169-171)tcC>tcT	p.S57S	CLEC4M_ENST00000334806.5_Silent_p.S29S|CLEC4M_ENST00000359059.5_Intron|CLEC4M_ENST00000597522.1_Silent_p.S57S|CLEC4M_ENST00000596707.1_Intron|CLEC4M_ENST00000248228.4_Silent_p.S57S|CLEC4M_ENST00000596363.1_Silent_p.S29S|CLEC4M_ENST00000394122.2_Silent_p.S49S|CLEC4M_ENST00000595496.1_Intron|CLEC4M_ENST00000357361.2_Silent_p.S57S	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	57					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						AACTCCTCTCCTTCATGCTCT	0.622000													34	101					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41009435	41009435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41009435C>T	ENST00000399564.4	-	32	3817	c.3367G>A	c.(3367-3369)Gac>Aac	p.D1123N	MROH2B_ENST00000506092.2_Missense_Mutation_p.D678N	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TCCAGTTTGTCTATTAAGGCT	0.507000													29	78					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061487	9061487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9061487C>T	ENST00000397910.4	-	3	26162	c.25959G>A	c.(25957-25959)gtG>gtA	p.V8653V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8655	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTTATAAATCACAGTCCCTA	0.448000													21	58					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544322	82544322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82544322G>A	ENST00000423517.2	-	7	13317	c.12980C>T	c.(12979-12981)tCc>tTc	p.S4327F	PCLO_ENST00000437081.1_Missense_Mutation_p.S1047F|PCLO_ENST00000333891.8_Missense_Mutation_p.S4327F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4258					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATGACTAAAGGAAACATCTAG	0.423000													21	43					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142178189	142178189	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142178189C>T	ENST00000519811.1	+	13	1910	c.1840C>T	c.(1840-1842)Cat>Tat	p.H614Y	DENND3_ENST00000424248.1_Missense_Mutation_p.H482Y|DENND3_ENST00000262585.2_Missense_Mutation_p.H534Y			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	534										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GCAGGCATACCATGCCCACTT	0.532000													17	140					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34810239	34810239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34810239C>T	ENST00000338074.2	+	21	2721	c.2560C>T	c.(2560-2562)Cct>Tct	p.P854S	EPB41L1_ENST00000373946.3_Missense_Mutation_p.P674S|EPB41L1_ENST00000373950.2_Missense_Mutation_p.P745S|EPB41L1_ENST00000441639.1_Missense_Mutation_p.P752S|EPB41L1_ENST00000202028.5_Missense_Mutation_p.P752S|EPB41L1_ENST00000373941.1_Missense_Mutation_p.P853S	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	854	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					ACTGCAGCATCCTGATATGCT	0.522000													15	178					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220496784	220496784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220496784C>T	ENST00000358055.3	+	7	1418	c.906C>T	c.(904-906)gcC>gcT	p.A302A	SLC4A3_ENST00000373762.3_Silent_p.A329A|SLC4A3_ENST00000273063.6_Silent_p.A329A|SLC4A3_ENST00000497589.1_3'UTR|SLC4A3_ENST00000373760.2_Silent_p.A302A|SLC4A3_ENST00000317151.3_Silent_p.A302A			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	302					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGGCCTGGCCCCCATCCTTC	0.637000													18	52					0	0	1	0	0
FAHD2B	151313	broad.mit.edu	37	2	97757237	97757237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97757237G>A	ENST00000414820.1	-	3	477	c.207C>T	c.(205-207)ttC>ttT	p.F69F	FAHD2B_ENST00000468548.1_Intron|FAHD2B_ENST00000440566.2_Silent_p.F69F|FAHD2B_ENST00000272610.3_Silent_p.F69F			Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing 2B	69							hydrolase activity|metal ion binding			kidney(5)|large_intestine(2)|lung(3)|skin(2)	12						CCTGCTCTAGGAACTGCGTCA	0.607000													17	55					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31324936	31324936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31324936G>A	ENST00000269197.5	+	12	5124	c.5124G>A	c.(5122-5124)atG>atA	p.M1708I		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1708			M -> V (in dbSNP:rs7232237).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CACAGAACATGAAAGCTTCCA	0.552000													30	69					0	0	1	0	0
PACS2	23241	broad.mit.edu	37	14	105843141	105843141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105843141C>T	ENST00000447393.1	+	9	1013	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S	PACS2_ENST00000325438.8_Missense_Mutation_p.P280S|PACS2_ENST00000430725.2_Missense_Mutation_p.P205S|PACS2_ENST00000547217.1_Missense_Mutation_p.P250S|PACS2_ENST00000458164.2_Missense_Mutation_p.P280S	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	280					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GGAGCACATCCCCGAGGCAGA	0.677000													14	64					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33560122	33560122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:33560122C>T	ENST00000228567.3	-	3	975	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	SYT10_ENST00000535526.1_Missense_Mutation_p.E46K	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	227						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTGACATCTTCGTTTTGGTTG	0.383000													18	48					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26725472	26725472	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26725472C>T	ENST00000396005.3	-	5	857	c.548G>A	c.(547-549)tGg>tAg	p.W183*	SLC5A12_ENST00000280467.6_Nonsense_Mutation_p.W183*	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	183					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						TGCATCTGTCCACACCACTGC	0.433000													43	141					0	0	1	0	0
NRBF2	29982	broad.mit.edu	37	10	64893181	64893181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:64893181C>T	ENST00000435510.2	+	1	97	c.6C>T	c.(4-6)ttC>ttT	p.F2F	NRBF2_ENST00000277746.6_5'UTR			Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	0					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding			large_intestine(2)|lung(3)|skin(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCTCCATGTTCCCCGGCGCCA	0.627000													10	16					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157805786	157805786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157805786C>T	ENST00000368174.4	-	3	311	c.215G>A	c.(214-216)gGa>gAa	p.G72E	CD5L_ENST00000484609.1_5'UTR	NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	72	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACTAGGGGTTCCGCTGGCAGC	0.542000													28	249					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70933619	70933619	+	Missense_Mutation	SNP	C	C	T	rs150844276	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70933619C>T	ENST00000334414.6	-	25	5728	c.5684G>A	c.(5683-5685)cGg>cAg	p.R1895Q	PTPRB_ENST00000550358.1_Missense_Mutation_p.R1807Q|PTPRB_ENST00000261266.5_Missense_Mutation_p.R1677Q|PTPRB_ENST00000451516.2_Missense_Mutation_p.R1587Q|PTPRB_ENST00000538708.1_Missense_Mutation_p.R1587Q|PTPRB_ENST00000550857.1_Missense_Mutation_p.R1587Q	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1677	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGAAGTTTTCCGGTTACTGTG	0.353000													22	85					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	18014197	18014197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18014197C>T	ENST00000361221.3	+	27	3298	c.3139C>T	c.(3139-3141)Ctg>Ttg	p.L1047L	ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000452522.1_Silent_p.L1008L|ARHGEF10L_ENST00000375415.1_Silent_p.L1008L|ARHGEF10L_ENST00000375408.3_Silent_p.L820L|ARHGEF10L_ENST00000434513.1_Silent_p.L1042L|ARHGEF10L_ENST00000167825.4_Silent_p.L750L	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	1047					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CCTGGAGCATCTGCAAGAGAT	0.642000													11	49					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938588	2938588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2938588C>T	ENST00000378404.2	+	1	543	c.338C>T	c.(337-339)tCc>tTc	p.S113F		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	113						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		ACGGAGCCCTCCCTGAACCCC	0.602000													32	61					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86124923	86124923	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86124923C>T	ENST00000394518.2	+	7	3719	c.3624C>T	c.(3622-3624)gcC>gcT	p.A1208A	AKAP13_ENST00000361243.2_Silent_p.A1208A	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1208					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						ATGATGGGGCCCCAGCTGGTG	0.597000													15	63					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79387418	79387418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:79387418G>A	ENST00000370742.3	-	9	1200	c.1137C>T	c.(1135-1137)acC>acT	p.T379T		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	379	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TGCCATTCATGGTATCAGGTG	0.398000													30	80					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184210648	184210648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:184210648C>T	ENST00000403733.3	+	21	3443	c.3244C>T	c.(3244-3246)Cgc>Tgc	p.R1082C	WWC2_ENST00000504005.1_Missense_Mutation_p.R764C|WWC2_ENST00000448232.2_Missense_Mutation_p.R1106C|WWC2_ENST00000513834.1_Missense_Mutation_p.R1033C|WWC2_ENST00000508747.1_Missense_Mutation_p.R210C	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1082										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		CCGGCAGAGCCGCCTCAATGA	0.567000													8	32					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140481402	140481402	+	Missense_Mutation	SNP	C	C	T	rs121913358		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:140481402C>T	ENST00000288602.6	-	11	1466	c.1406G>A	c.(1405-1407)gGa>gAa	p.G469E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	469	Protein kinase.		G -> A (in NHL; also in a lung adenocarcinoma sample; somatic mutation; elevated kinase activity; efficiently induces cell transformation).|G -> E (in CFC syndrome and colon cancer).|G -> R (in NHL).|G -> V (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G469A(19)|p.G469V(13)|p.G469S(5)|p.G469E(5)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GTAGACTGTTCCAAATGATCC	0.373000	G469A(NCIH1395_LUNG)|G469A(NCIH1755_LUNG)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				31	146					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51960931	51960931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51960931G>A	ENST00000321424.3	-	2	583	c.517C>T	c.(517-519)Ctg>Ttg	p.L173L	SIGLEC8_ENST00000340550.5_Intron|SIGLEC8_ENST00000430817.1_Intron	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	173	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GAGCAGGTCAGGTTCCTGGAG	0.627000													30	101					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16373106	16373106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16373106C>T	ENST00000375679.4	+	4	417	c.306C>T	c.(304-306)gcC>gcT	p.A102A		NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCTGTGGCCCTCGTCTCTT	0.597000													20	66					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20249310	20249310	+	Missense_Mutation	SNP	C	C	T	rs3968186		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20249310C>T	ENST00000315957.4	+	1	910	c.829C>T	c.(829-831)Cat>Tat	p.H277Y		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTCTGTGTTTCATACTGTAAT	0.388000													32	80					0	0	1	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342314	60342314	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60342314G>A	ENST00000581291.1	-	0	1839																				breast(2)|kidney(1)|lung(2)	5						ACGAGGAGGCGAAGCTTGCTT	0.468000													42	98					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9799447	9799447	+	Silent	SNP	C	C	T	rs141116659		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9799447C>T	ENST00000256460.3	-	11	1173	c.996G>A	c.(994-996)gcG>gcA	p.A332A	OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	332					cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		CCCCATGGCTCGCCGTCTGCC	0.652000													25	72					0	0	1	0	0
SNAPC2	6618	broad.mit.edu	37	19	7987638	7987638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7987638C>T	ENST00000221573.6	+	5	1045	c.994C>T	c.(994-996)Cct>Tct	p.P332S	SNAPC2_ENST00000597584.1_Missense_Mutation_p.P95S	NM_003083.3	NP_003074.1	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex, polypeptide 2, 45kDa	332					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						GGCAGCCACCCCTGCCAGGTG	0.687000													39	103					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173916423	173916423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:173916423G>A	ENST00000264111.6	+	31	3148	c.2961G>A	c.(2959-2961)cgG>cgA	p.R987R	RAPGEF4_ENST00000538974.1_Silent_p.R817R|RAPGEF4_ENST00000535187.1_Silent_p.R768R|RAPGEF4_ENST00000539331.1_Silent_p.R835R|RAPGEF4_ENST00000540783.1_Silent_p.R835R|RAPGEF4_ENST00000397081.3_Silent_p.R988R|RAPGEF4_ENST00000409036.1_Silent_p.R920R|RAPGEF4_ENST00000397087.3_Silent_p.R844R			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	988	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GTTATGTACGGCAATTAAATG	0.408000													24	60					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113196700	113196700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113196700C>T	ENST00000401783.2	-	30	5311	c.4975G>A	c.(4975-4977)Gat>Aat	p.D1659N	SVEP1_ENST00000374469.1_Missense_Mutation_p.D1636N	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1659	Sushi 5.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AAGCCTGGATCACAGAACAGA	0.502000													8	22					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784037	9784037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9784037C>T	ENST00000304374.2	+	1	780	c.384C>T	c.(382-384)atC>atT	p.I128I		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	128					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CTGCCTCCATCCTGAACCTGT	0.622000													6	40					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39871208	39871208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39871208G>A	ENST00000502986.2	+	10	1125	c.883G>A	c.(883-885)Ggc>Agc	p.G295S	IDO2_ENST00000389060.4_Missense_Mutation_p.G282S|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	282					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						TGAGTTCTTAGGCATTCGTCA	0.458000													8	42					0	0	1	0	0
WFDC2	10406	broad.mit.edu	37	20	44108342	44108342	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44108342G>A	ENST00000217425.5	+	3	310	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	WFDC2_ENST00000342873.3_5'UTR|WFDC2_ENST00000339946.3_Intron|WFDC2_ENST00000372676.3_Intron|WFDC2_ENST00000488143.1_3'UTR			Q14508	WFDC2_HUMAN	WAP four-disulfide core domain 2	0	WAP 2.				proteolysis|spermatogenesis	extracellular space	serine-type endopeptidase inhibitor activity			lung(1)	1		Myeloproliferative disorder(115;0.0122)				cctaggccacgaaggcccact	0.542000													39	65					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94056942	94056942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94056942C>T	ENST00000297268.6	+	49	3742	c.3271C>T	c.(3271-3273)Ccc>Tcc	p.P1091S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	1091					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTTGCAGGGCCCCCCTGGTCC	0.532000										HNSCC(75;0.22)			42	109					0	0	1	0	0
BAAT	570	broad.mit.edu	37	9	104125158	104125158	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104125158T>A	ENST00000259407.2	-	4	917	c.809A>T	c.(808-810)tAt>tTt	p.Y270F	BAAT_ENST00000395051.3_Missense_Mutation_p.Y270F	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	270					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	CTGACCATGATATACCTGTGG	0.438000													29	59					0	0	1	0	0
DMRTA1	63951	broad.mit.edu	37	9	22451350	22451350	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:22451350C>T	ENST00000325870.1	+	2	1180	c.955C>T	c.(955-957)Ctt>Ttt	p.L319F		NM_022160.2	NP_071443.2	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	319					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		CAAGGCAAGCCTTCCGACAGT	0.478000													6	49					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50701195	50701195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50701195G>A	ENST00000355832.5	-	8	1867	c.1789C>T	c.(1789-1791)Cta>Tta	p.L597L	ERCC6_ENST00000542458.1_Intron	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	597	Helicase ATP-binding.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GTTTCATGTAGAATTGCCACT	0.413000								Direct reversal of damage;Nucleotide excision repair (NER)					12	42					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75679468	75679468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75679468G>A	ENST00000370855.5	-	22	1997	c.1884C>T	c.(1882-1884)gcC>gcT	p.A628A	SLC44A5_ENST00000370859.3_Silent_p.A628A|SLC44A5_ENST00000535611.1_Silent_p.A498A	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	628						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						AGAATAGGAAGGCCAGAACAC	0.368000													40	92					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16612290	16612290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:16612290G>A	ENST00000443444.2	+	5	1059	c.919G>A	c.(919-921)Gaa>Aaa	p.E307K	CCDC144A_ENST00000456009.1_Intron|RP11-219A15.1_ENST00000448331.3_Missense_Mutation_p.E307K|CCDC144A_ENST00000360524.8_Missense_Mutation_p.E307K|CCDC144A_ENST00000340621.5_Missense_Mutation_p.E306K|CCDC144A_ENST00000399273.1_Missense_Mutation_p.E307K			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	307																	TGAAATTTATGAAAAATACAA	0.338000													22	38					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71762184	71762184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71762184C>T	ENST00000258104.3	+	14	1595	c.1318C>T	c.(1318-1320)Cct>Tct	p.P440S	DYSF_ENST00000410041.1_Missense_Mutation_p.P472S|DYSF_ENST00000429174.2_Missense_Mutation_p.P440S|DYSF_ENST00000409744.1_Missense_Mutation_p.P441S|DYSF_ENST00000410020.3_Missense_Mutation_p.P472S|DYSF_ENST00000394120.2_Missense_Mutation_p.P441S|DYSF_ENST00000409366.1_Missense_Mutation_p.P441S|DYSF_ENST00000409582.3_Missense_Mutation_p.P471S|DYSF_ENST00000413539.2_Missense_Mutation_p.P471S|DYSF_ENST00000409651.1_Missense_Mutation_p.P472S|DYSF_ENST00000409762.1_Missense_Mutation_p.P471S	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	440	C2 3.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GACGGCCAACCCTCAGTGGAA	0.627000													15	62					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85935348	85935348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:85935348G>A	ENST00000383699.3	+	5	1027	c.400G>A	c.(400-402)Gaa>Aaa	p.E134K	CADM2_ENST00000407528.2_Missense_Mutation_p.E125K|CADM2_ENST00000405615.2_Missense_Mutation_p.E127K	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	125	Ig-like C2-type 1.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AGGTGTTCCTGAAAAGCCTCA	0.393000													17	58					0	0	1	0	0
MARK4	57787	broad.mit.edu	37	19	45801408	45801408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45801408C>T	ENST00000300843.4	+	16	2182	c.1885C>T	c.(1885-1887)Ctc>Ttc	p.L629F	MARK4_ENST00000262891.4_Intron	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	629					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CAGGGTTACCCTCGATCCCTC	0.597000													11	45					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121439	50121439	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50121439C>T	ENST00000374160.3	-	1	838	c.762G>A	c.(760-762)tgG>tgA	p.W254*	WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron|RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Nonsense_Mutation_p.W254*	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	254						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CAAGTCACCTCCAGTCTTCCC	0.547000													57	150					0	0	1	0	0
DCD	117159	broad.mit.edu	37	12	55038536	55038536	+	Missense_Mutation	SNP	G	G	A	rs139716642		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55038536G>A	ENST00000456047.2	-	6	547	c.358C>T	c.(358-360)Cgt>Tgt	p.R120C	DCD_ENST00000293371.6_Silent_p.A98A			P81605	DCD_HUMAN	dermcidin	0					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			large_intestine(2)|lung(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(1001;0.0255)				CGTCATGGACGGCTCCTAGGA	0.488000													9	19					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1457134	1457134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1457134G>A	ENST00000535453.1	+	8	2812	c.1099G>A	c.(1099-1101)Gag>Aag	p.E367K	APC2_ENST00000233607.2_Missense_Mutation_p.E367K|APC2_ENST00000238483.4_Intron			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	367					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGCGCAAGGAGATGCGCGT	0.731000													4	4					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49005761	49005761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:49005761C>T	ENST00000226432.4	+	7	995	c.812C>T	c.(811-813)tCa>tTa	p.S271L	CWH43_ENST00000513409.1_Missense_Mutation_p.S244L	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	271					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						GGAACAGCTTCAGCTGCGGGG	0.502000													42	86					0	0	1	0	0
PRPF31	26121	broad.mit.edu	37	19	54625919	54625919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54625919C>T	ENST00000321030.4	+	5	715	c.366C>T	c.(364-366)ttC>ttT	p.F122F	AC012314.8_ENST00000452097.1_RNA|PRPF31_ENST00000498612.1_3'UTR|PRPF31_ENST00000391755.1_Silent_p.F122F|PRPF31_ENST00000419967.1_Silent_p.F122F	NM_015629.3	NP_056444.3	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31	122					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)|urinary_tract(3)	12	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAAAGAGATTCCCTGAACTGG	0.537000													144	95					0	0	1	0	0
TMEM59L	25789	broad.mit.edu	37	19	18731332	18731332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18731332C>T	ENST00000600490.1	+	9	1200	c.1015C>T	c.(1015-1017)Ctg>Ttg	p.L339L	TMEM59L_ENST00000262817.3_Silent_p.L339L			Q9UK28	TM59L_HUMAN	transmembrane protein 59-like	339						Golgi membrane|integral to membrane|membrane fraction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(2)	13						GAAGCTGGACCTGACCAAGCT	0.662000													18	51					0	0	1	0	0
TNFRSF10C	8794	broad.mit.edu	37	8	22974279	22974279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22974279C>T	ENST00000356864.3	+	5	1047	c.515C>T	c.(514-516)cCg>cTg	p.P172L	TNFRSF10C_ENST00000540813.1_Missense_Mutation_p.P70L	NM_003841.3	NP_003832.2	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	172					apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(6)|lung(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		AACACCAGCCCGGGGACTCCT	0.562000													14	143					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59113078	59113078	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:59113078G>A	ENST00000395153.3	+	4	1773	c.1626G>A	c.(1624-1626)gtG>gtA	p.V542V	DACT1_ENST00000541264.2_Silent_p.V298V|DACT1_ENST00000395151.3_Silent_p.V298V|DACT1_ENST00000335867.4_Silent_p.V579V|DACT1_ENST00000556859.1_Silent_p.V298V	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	579					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						TGGGCGTCGTGAAGAACTCCA	0.662000													9	26					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166408671	166408671	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:166408671A>C	ENST00000402744.4	+	6	1335	c.1055A>C	c.(1054-1056)gAg>gCg	p.E352A		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	352					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCACCTGAAGAGACTCTGAAG	0.453000													20	61					0	0	1	0	0
KAZN	23254	broad.mit.edu	37	1	14925592	14925592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:14925592C>T	ENST00000376030.2	+	1	393	c.99C>T	c.(97-99)acC>acT	p.T33T	KAZN_ENST00000503743.1_Silent_p.T33T|KAZN_ENST00000422387.2_Silent_p.T33T	NM_201628.2	NP_963922.2	Q674X7	KAZRN_HUMAN	kazrin, periplakin interacting protein	33					keratinization	cornified envelope|cytoplasm|desmosome|nucleus				central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(1)|prostate(2)	25						TCACGGCCACCAACCGGAGAC	0.731000													12	40					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20168604	20168604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20168604G>A	ENST00000245957.5	+	14	1492	c.1416G>A	c.(1414-1416)ttG>ttA	p.L472L	C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	472										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		CCACTCTCTTGGATACTCCTG	0.393000													17	91					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14851538	14851538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14851538C>T	ENST00000358984.4	+	36	3418	c.3238C>T	c.(3238-3240)Ctc>Ttc	p.L1080F		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1165										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TGAAAATGATCTCTTTCATGA	0.308000													9	13					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27800631	27800631	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27800631C>T	ENST00000408964.2	+	1	1243	c.1192C>T	c.(1192-1194)Caa>Taa	p.Q398*		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	398										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GTTAGGACATCAAGTCCCAGA	0.438000													37	71					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585704	82585704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82585704G>A	ENST00000423517.2	-	5	4902	c.4565C>T	c.(4564-4566)tCa>tTa	p.S1522L	PCLO_ENST00000333891.8_Missense_Mutation_p.S1522L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1453					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGAACAGGTGAGTTTTCACT	0.423000													18	31					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238270463	238270463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238270463G>A	ENST00000295550.4	-	15	6527	c.6075C>T	c.(6073-6075)gcC>gcT	p.A2025A	COL6A3_ENST00000353578.4_Silent_p.A1819A|COL6A3_ENST00000409809.1_Silent_p.A1819A|COL6A3_ENST00000472056.1_Silent_p.A1418A|COL6A3_ENST00000346358.4_Silent_p.A1825A|COL6A3_ENST00000347401.3_Silent_p.A1824A	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2025	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AAGCTTTCTCGGCAATGTTGT	0.522000													23	84					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20652291	20652291	+	Silent	SNP	C	C	T	rs143680068	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20652291C>T	ENST00000525748.1	+	10	1827	c.1554C>T	c.(1552-1554)ttC>ttT	p.F518F	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	518					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	TTGCCGGCTTCGTCATCTTCT	0.493000													35	100					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841872	13841872	+	Missense_Mutation	SNP	G	G	A	rs142155986	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13841872G>A	ENST00000265104.4	-	33	5517	c.5413C>T	c.(5413-5415)Cgc>Tgc	p.R1805C		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1805	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCTGCCTGGCGAATCACAAGA	0.408000									Kartagener syndrome				37	92					0	0	1	0	0
CHMP1B	57132	broad.mit.edu	37	18	11851674	11851674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:11851674C>T	ENST00000526991.2	+	1	280	c.164C>T	c.(163-165)gCc>gTc	p.A55V	GNAL_ENST00000535121.1_Intron|GNAL_ENST00000334049.6_Intron|GNAL_ENST00000269162.5_Intron|GNAL_ENST00000423027.3_Intron|RP11-78A19.3_ENST00000586474.1_RNA	NM_020412.4	NP_065145.2	Q7LBR1	CHM1B_HUMAN	charged multivesicular body protein 1B	55					cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|lung(1)|urinary_tract(1)	3						GCCGAAAATGCCATCCGCCAG	0.527000													15	42					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43099815	43099815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43099815C>T	ENST00000230419.4	+	6	1095	c.874C>T	c.(874-876)Cgg>Tgg	p.R292W	PTK7_ENST00000481273.1_Missense_Mutation_p.R300W|PTK7_ENST00000345201.2_Missense_Mutation_p.R292W|PTK7_ENST00000349241.2_Missense_Mutation_p.R292W|PTK7_ENST00000352931.2_Missense_Mutation_p.R292W|PTK7_ENST00000471863.1_Missense_Mutation_p.R292W	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	292	Ig-like C2-type 3.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.R292W(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GACCCAGGTCCGGCCACGCAA	0.617000													26	56					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11596500	11596500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11596500C>T	ENST00000304391.6	+	5	713	c.595C>T	c.(595-597)Cgc>Tgc	p.R199C	PTCHD2_ENST00000389575.3_Silent_p.I1312I|PTCHD2_ENST00000294484.6_Silent_p.I1312I			Q9P2K9	PTHD2_HUMAN	patched domain containing 2	0					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCTGCATCATCGCCCCATTTG	0.637000													27	69					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178769882	178769882	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:178769882G>A	ENST00000286063.5	-	3	1421	c.1104C>T	c.(1102-1104)atC>atT	p.I368I	PDE11A_ENST00000358450.4_Silent_p.I118I|PDE11A_ENST00000409504.1_Silent_p.I10I|PDE11A_ENST00000449286.2_Silent_p.I10I|PDE11A_ENST00000497003.1_5'UTR	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	368	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TAGATATGGCGATTCCACAAA	0.363000									Primary Pigmented Nodular Adrenocortical Disease, Familial				12	40					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15651288	15651288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15651288C>T	ENST00000269703.2	+	8	898	c.699C>T	c.(697-699)atC>atT	p.I233I	CYP4F22_ENST00000601005.2_Silent_p.I233I	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	233						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	p.I233I(1)		endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						TCTCCGCTATCATTGAACTGA	0.557000													28	75					0	0	1	0	0
PRRG1	5638	broad.mit.edu	37	X	37312709	37312709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37312709C>T	ENST00000542554.1	+	5	764	c.492C>T	c.(490-492)tcC>tcT	p.S164S	PRRG1_ENST00000449135.2_Silent_p.S164S|TM4SF2_ENST00000465127.1_Intron|PRRG1_ENST00000543642.1_Silent_p.S164S|PRRG1_ENST00000378628.4_Silent_p.S164S|PRRG1_ENST00000491253.1_3'UTR	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	164						extracellular region|integral to plasma membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						CTCGCCTGTCCAATTGTGATC	0.542000													30	27					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995791	19995791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:19995791G>A	ENST00000391403.2	-	1	2087	c.1984C>T	c.(1984-1986)Cct>Tct	p.P662S		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	662	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGAGGTGGAGGAACAAAGCCA	0.473000													96	233					0	0	1	0	0
CDC25A	993	broad.mit.edu	37	3	48209415	48209415	+	Missense_Mutation	SNP	G	G	A	rs141219026	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48209415G>A	ENST00000302506.3	-	10	1358	c.950C>T	c.(949-951)tCc>tTc	p.S317F	CDC25A_ENST00000351231.3_Missense_Mutation_p.S277F|CDC25A_ENST00000459900.1_5'UTR	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	317					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		AGATGCCAGGGATAAAGACTG	0.443000													15	44					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124624623	124624623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124624623G>A	ENST00000278927.5	-	5	773	c.644C>T	c.(643-645)tCg>tTg	p.S215L	ESAM_ENST00000442070.2_Missense_Mutation_p.S36L	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	215	Ig-like C2-type.				blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		CATGGAAGACGAAAGGTTGGT	0.483000													51	131					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22163861	22163861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:22163861C>T	ENST00000389397.4	+	32	3479	c.617C>T	c.(616-618)gCt>gTt	p.A206V	VWA3A_ENST00000389398.5_Missense_Mutation_p.A1104V|VWA3A_ENST00000563755.1_Missense_Mutation_p.A206V			A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1104						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		AGAAAGCTGGCTTCCTTCACC	0.567000													7	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064299	9064299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9064299G>A	ENST00000397910.4	-	3	23350	c.23147C>T	c.(23146-23148)cCt>cTt	p.P7716L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7718	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAAGTCACAGGAAGGGGAGA	0.547000													14	77					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57745960	57745960	+	Missense_Mutation	SNP	G	G	A	rs149480547		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57745960G>A	ENST00000281282.5	+	7	2212	c.2134G>A	c.(2134-2136)Gat>Aat	p.D712N		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	712						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGAAATGCACGATGAACTGGA	0.562000													10	34					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24559266	24559266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24559266G>A	ENST00000535378.1	-	18	3324	c.2682C>T	c.(2680-2682)ttC>ttT	p.F894F	KIAA0319_ENST00000543707.1_Silent_p.F903F|KIAA0319_ENST00000430948.2_Silent_p.F858F|KIAA0319_ENST00000378214.3_Silent_p.F903F|KIAA0319_ENST00000537886.1_Silent_p.F903F	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	903					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						TCAAGACCTTGAAAAGCAAGA	0.453000													7	18					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4928848	4928848	+	Silent	SNP	G	G	A	rs146129201		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4928848G>A	ENST00000359350.4	+	1	249	c.249G>A	c.(247-249)agG>agA	p.R83R	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATGTTGAGGGTCTTCTTGT	0.468000													35	125					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73749129	73749129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73749129C>T	ENST00000276033.5	+	5	1640	c.1474C>T	c.(1474-1476)Ctt>Ttt	p.L492F	SLC16A2_ENST00000587091.1_Missense_Mutation_p.L418F			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	418						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	CGTCGTCTGTCTTTTCCTGGG	0.577000													15	11					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43893672	43893672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43893672C>T	ENST00000450892.2	-	24	4700	c.4623G>A	c.(4621-4623)cgG>cgA	p.R1541R	STRC_ENST00000541030.1_Silent_p.R768R	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1541					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		CCTGTAGTTCCCGATCTCCTA	0.552000													37	83					0	0	1	0	0
CDC123	8872	broad.mit.edu	37	10	12279228	12279228	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:12279228C>T	ENST00000281141.4	+	9	931	c.651C>T	c.(649-651)ttC>ttT	p.F217F	CDC123_ENST00000378900.2_Intron|CDC123_ENST00000455773.3_3'UTR	NM_006023.2	NP_006014.2	O75794	CD123_HUMAN	cell division cycle 123	217					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm		p.F217L(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12						AAGACTTTTTCAAGAAACACA	0.289000													28	67					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492823	21492823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:21492823C>T	ENST00000377142.4	-	2	916	c.560G>A	c.(559-561)cGg>cAg	p.R187Q	NKX2-2-AS1_ENST00000549659.1_RNA	NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	187					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						TTTCTCGGCCCGGGCGCGCTT	0.677000													15	38					0	0	1	0	0
TEDDM1	127670	broad.mit.edu	37	1	182368876	182368876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:182368876G>A	ENST00000367565.1	-	1	875	c.745C>T	c.(745-747)Ctc>Ttc	p.L249F		NM_172000.3	NP_741997.3	Q5T9Z0	TEDM1_HUMAN	transmembrane epididymal protein 1	249						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)	7						AACTTGTAGAGGGGTCCTGGA	0.517000													32	55					0	0	1	0	0
EEF1A2	1917	broad.mit.edu	37	20	62126323	62126323	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62126323C>T	ENST00000217182.3	-	4	621	c.456G>A	c.(454-456)gtG>gtA	p.V152V	EEF1A2_ENST00000298049.7_Silent_p.V152V	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	152						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CCATTTTGTTCACGCCCACGA	0.607000													13	96					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120192591	120192591	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:120192591C>T	ENST00000450251.1	+	12	2120	c.1576C>T	c.(1576-1578)Cga>Tga	p.R526*	USP53_ENST00000274030.6_Nonsense_Mutation_p.R526*			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	526					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						ACCTCAGAGTCGAGCTTCTGC	0.398000													31	71					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475757	140475757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140475757C>T	ENST00000194155.4	+	1	1531	c.1383C>T	c.(1381-1383)ttC>ttT	p.F461F		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		461	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.632000													54	207					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173961099	173961099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:173961099C>T	ENST00000506823.1	+	13	2311	c.1654C>T	c.(1654-1656)Cat>Tat	p.H552Y	GALNTL6_ENST00000508122.1_Missense_Mutation_p.H535Y	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	552	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						AACATTATTCCATCCTGTGAG	0.428000													21	64					0	0	1	0	0
IP6K3	117283	broad.mit.edu	37	6	33693290	33693290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33693290C>T	ENST00000451316.1	-	6	1228	c.693G>A	c.(691-693)aaG>aaA	p.K231K	IP6K3_ENST00000293756.4_Silent_p.K231K	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	231					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						GGCGGGCCTTCTTCTCCTCCG	0.607000													13	36					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179408964	179408964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179408964C>T	ENST00000589042.1	-	345	96216	c.95992G>A	c.(95992-95994)Gaa>Aaa	p.E31998K	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E29430K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E30357K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E23125K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E23058K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E22933K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30357	Ig-like 142.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAATTGATTCGCTGTATTCG	0.383000													21	52					0	0	1	0	0
REG3A	5068	broad.mit.edu	37	2	79384754	79384754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79384754C>T	ENST00000393878.1	-	4	658	c.404G>A	c.(403-405)aGa>aAa	p.R135K	REG3A_ENST00000409839.3_Missense_Mutation_p.R135K|REG3A_ENST00000305165.2_Missense_Mutation_p.R135K	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	135	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						GGAGGGATTTCTCTCCCATGC	0.537000													38	94					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435398	158435398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158435398G>A	ENST00000289451.2	+	1	127	c.47G>A	c.(46-48)gGc>gAc	p.G16D		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					GTCGTCCTCGGCTTCTCATCC	0.507000													12	58					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94707034	94707034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94707034C>T	ENST00000304338.3	+	9	1032	c.878C>T	c.(877-879)cCc>cTc	p.P293L		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	293						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						ACTATACTTCCCTTAGTGAAA	0.308000													10	33					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56246224	56246224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56246224G>A	ENST00000361673.3	-	4	1997	c.1784C>T	c.(1783-1785)tCc>tTc	p.S595F	ALPK2_ENST00000587399.1_5'UTR	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	595							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						ATCAGCATGGGAACTCCGACC	0.488000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	85					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2211188	2211188	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2211188C>T	ENST00000398665.3	+	15	1478	c.1442C>T	c.(1441-1443)cCg>cTg	p.P481L		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	481						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCCCACCCCGCCCGCGCTG	0.672000													29	67					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67066476	67066476	+	Silent	SNP	G	G	A	rs147341587		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:67066476G>A	ENST00000315962.4	+	9	1804	c.1431G>A	c.(1429-1431)tcG>tcA	p.S477S	TRIM55_ENST00000350034.4_Intron|TRIM55_ENST00000353317.5_Intron|TRIM55_ENST00000276573.7_Silent_p.S477S	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	477						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CTGAGGATTCGAATGTACGGA	0.567000													29	42					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180056987	180056987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180056987C>T	ENST00000261937.6	-	5	710	c.632G>A	c.(631-633)gGa>gAa	p.G211E	FLT4_ENST00000393347.3_Missense_Mutation_p.G211E|FLT4_ENST00000502649.1_Missense_Mutation_p.G211E|FLT4_ENST00000424276.2_5'UTR	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	211	Ig-like C2-type 2.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTCCTGGTCTCCCCAGGTGGT	0.642000													25	36					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11642314	11642314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11642314G>A	ENST00000262442.3	+	29	6000	c.5932G>A	c.(5932-5934)Ggc>Agc	p.G1978S	DNAH9_ENST00000454412.2_Missense_Mutation_p.G1978S	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1978	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGGCTATGCTGGCCGCACAGA	0.488000													11	37					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8521544	8521544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8521544G>A	ENST00000381196.4	-	17	1237	c.694C>T	c.(694-696)Cgc>Tgc	p.R232C	PTPRD_ENST00000397611.3_Missense_Mutation_p.R229C|PTPRD_ENST00000397617.3_Missense_Mutation_p.R222C|PTPRD_ENST00000540109.1_Missense_Mutation_p.R232C|PTPRD_ENST00000360074.4_Missense_Mutation_p.R219C|PTPRD_ENST00000537002.1_Missense_Mutation_p.R229C|PTPRD_ENST00000358503.5_Missense_Mutation_p.R219C|PTPRD_ENST00000486161.1_Missense_Mutation_p.R232C|PTPRD_ENST00000356435.5_Missense_Mutation_p.R232C|PTPRD_ENST00000355233.5_Missense_Mutation_p.R232C|PTPRD_ENST00000397606.3_Missense_Mutation_p.R222C	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	232					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.R232C(2)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGGACACGGCGAACTGGAACA	0.448000										TSP Lung(15;0.13)			29	71					0	0	1	0	0
ZNF724P	440519	broad.mit.edu	37	19	23405633	23405633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23405633G>A	ENST00000418100.1	-	4	1531	c.1414C>T	c.(1414-1416)Cat>Tat	p.H472Y																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						TCTCCAGTATGAATTATCCTA	0.368000													28	84					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28575418	28575418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:28575418C>T	ENST00000220562.4	+	3	2744	c.1842C>T	c.(1840-1842)ttC>ttT	p.F614F	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Silent_p.F230F	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	614						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TCCATCTTTTCCCCCACACTC	0.572000													22	116					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551633	35551633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35551633G>A	ENST00000262626.2	+	9	1548	c.723G>A	c.(721-723)ggG>ggA	p.G241G	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Silent_p.G83G|HPN_ENST00000392226.1_Silent_p.G241G	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	241	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	TCTACCACGGGGGCTATCTTC	0.642000													24	76					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719089	140719089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140719089G>A	ENST00000394576.2	+	1	551	c.551G>A	c.(550-552)aGg>aAg	p.R184K	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGTGCGAAGGGGAGCTGAT	0.562000													33	92					0	0	1	0	0
SKAP2	8935	broad.mit.edu	37	7	26766566	26766566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:26766566G>A	ENST00000345317.2	-	7	842	c.529C>T	c.(529-531)Cta>Tta	p.L177L	SKAP2_ENST00000539623.1_Silent_p.L5L|SKAP2_ENST00000489977.1_5'UTR	NM_003930.3	NP_003921.2	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	177	PH.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						TCCTTTCTTAGAGTGTTATTC	0.323000													5	59					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37164388	37164388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:37164388G>A	ENST00000274258.7	-	37	7802	c.4215C>T	c.(4213-4215)ttC>ttT	p.F1405F	C5orf42_ENST00000508244.1_Silent_p.F2525F|C5orf42_ENST00000425232.2_Silent_p.F2525F			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2525								p.F1405F(1)|p.F2525F(1)		breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			AAGGAACGTCGAAGTCATCCA	0.318000													34	69					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108278674	108278674	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108278674G>A	ENST00000295746.8	-	16	2019	c.1943C>T	c.(1942-1944)gCt>gTt	p.A648V	KIAA1524_ENST00000491772.1_Missense_Mutation_p.A489V	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	648						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AAGGGCTAGAGCTTTTGTTTC	0.358000													15	46					0	0	1	0	0
CACNG1	786	broad.mit.edu	37	17	65040977	65040977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:65040977G>A	ENST00000226021.3	+	1	272	c.201G>A	c.(199-201)aaG>aaA	p.K67K		NM_000727.3	NP_000718.1	Q06432	CCG1_HUMAN	calcium channel, voltage-dependent, gamma subunit 1	67					muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(1)|large_intestine(2)|lung(2)|prostate(1)|skin(2)	8	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	ACGACAGCAAGACCTGCGGGC	0.652000													10	26					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932427	83932427	+	Missense_Mutation	SNP	C	C	T	rs149687703		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83932427C>T	ENST00000345382.2	-	4	1661	c.1576G>A	c.(1576-1578)Gaa>Aaa	p.E526K	BNC1_ENST00000569704.1_Missense_Mutation_p.E519K|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	526					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						AATGGCATTTCGTTTGAAATG	0.488000													35	124					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306689	41306689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:41306689C>T	ENST00000373198.3	-	7	1205	c.970G>A	c.(970-972)Gaa>Aaa	p.E324K	PTPRT_ENST00000373187.1_Missense_Mutation_p.E324K|PTPRT_ENST00000373193.3_Missense_Mutation_p.E324K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E324K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E324K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E324K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E324K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	324	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TATTCCACTTCCTTCAGGATG	0.567000													30	68					0	0	1	0	0
IL2	3558	broad.mit.edu	37	4	123374954	123374954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123374954C>T	ENST00000226730.4	-	3	546	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K		NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2	88					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		TTTAGCACTTCCTCCAGAGGT	0.368000			T	TNFRSF17	intestinal T-cell lymphoma								39	112					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017688	1017688	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1017688C>T	ENST00000421673.2	-	31	5163	c.5113G>A	c.(5113-5115)Gaa>Aaa	p.E1705K		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1705	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAGGTGGCTTCAGCATGGTGT	0.557000													79	620					0	0	1	0	0
MIR320A	407037	broad.mit.edu	37	8	22102552	22102552	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22102552G>A	ENST00000385302.1	-	0	4					NR_029714.1																						GGAGGGGAGCGAAGCGCCGCC	0.642000													21	72					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1271266	1271266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1271266G>A	ENST00000310581.5	-	8	2493	c.2436C>T	c.(2434-2436)ttC>ttT	p.F812F	TERT_ENST00000296820.5_Intron|TERT_ENST00000508104.2_Intron|TERT_ENST00000334602.6_Silent_p.F812F	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	812	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGTGGCACATGAAGCGTAGGA	0.652000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				6	52					0	0	1	0	0
SCIN	85477	broad.mit.edu	37	7	12691524	12691524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:12691524C>T	ENST00000297029.5	+	15	2119	c.2018C>T	c.(2017-2019)tCt>tTt	p.S673F	SCIN_ENST00000445618.2_Missense_Mutation_p.S426F|SCIN_ENST00000519209.1_Missense_Mutation_p.S426F	NM_001112706.2	NP_001106177.1	Q9Y6U3	ADSV_HUMAN	scinderin	673	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	17				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TCTCTGAAGTCTGGTAAGCTC	0.368000													4	6					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38877381	38877381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38877381G>A	ENST00000359357.3	+	63	9204	c.8950G>A	c.(8950-8952)Gag>Aag	p.E2984K	DNAH8_ENST00000441566.1_Missense_Mutation_p.E2948K|DNAH8_ENST00000449981.2_Missense_Mutation_p.E3201K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTGGCCAAGGGAGGCTCTGAT	0.448000													36	93					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955761	18955761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18955761G>A	ENST00000302797.3	-	1	795	c.571C>T	c.(571-573)Ctc>Ttc	p.L191F	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	191					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GACCCACAGAGAACCACACAT	0.507000													21	52					0	0	1	0	0
ERCC3	2071	broad.mit.edu	37	2	128029016	128029016	+	Missense_Mutation	SNP	G	G	A	rs139049289		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128029016G>A	ENST00000493187.2	-	12	2112	c.1649C>T	c.(1648-1650)tCg>tTg	p.S550L	ERCC3_ENST00000285398.2_Missense_Mutation_p.S614L			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	614	Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CAGATCAAACGAAGTGTCACC	0.423000			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				55	119					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160766091	160766091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160766091C>T	ENST00000263285.5	+	1	144	c.114C>T	c.(112-114)ttC>ttT	p.F38F	LY9_ENST00000368039.2_Silent_p.F38F|LY9_ENST00000471816.1_3'UTR|LY9_ENST00000368041.2_5'UTR|LY9_ENST00000341032.4_Silent_p.F38F|LY9_ENST00000368040.1_5'UTR	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	38					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTCTCCTCTTCCTGCTCATGG	0.493000													37	183					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56520206	56520206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56520206G>A	ENST00000390649.3	+	3	495	c.495G>A	c.(493-495)aaG>aaA	p.K165K		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	165						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GACCAAGCAAGGAAAAAGTGC	0.468000													4	18					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34129178	34129178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34129178C>T	ENST00000389232.4	+	88	11710	c.11640C>T	c.(11638-11640)tcC>tcT	p.S3880S	RYR3_ENST00000415757.3_Silent_p.S3875S	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3880					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGCTTCTGTCCCTCCTGGAAG	0.483000													11	15					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18391067	18391067	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:18391067G>A	ENST00000338745.6	-	11	3621	c.1887C>T	c.(1885-1887)ccC>ccT	p.P629P	SATB1_ENST00000417717.2_Silent_p.P661P|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Silent_p.P629P	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	629					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						AGGCCACCGTGGGTTGCCGTG	0.607000													20	44					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32014099	32014099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32014099C>T	ENST00000375244.3	-	31	10660	c.10459G>A	c.(10459-10461)Gac>Aac	p.D3487N	TNXB_ENST00000375247.2_Missense_Mutation_p.D3485N			P22105	TENX_HUMAN	tenascin XB	3532					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GGCTGCCCGTCCGTGTCCCTG	0.632000													10	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070533	9070533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9070533G>A	ENST00000397910.4	-	3	17116	c.16913C>T	c.(16912-16914)tCc>tTc	p.S5638F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5640	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGATGTCATGGAAGGTGACAT	0.527000													15	16					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6091063	6091063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6091063G>A	ENST00000217289.4	-	5	1416	c.628C>T	c.(628-630)Cct>Tct	p.P210S	FERMT1_ENST00000536936.1_Intron	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	210	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TCCGTCAAAGGGCTGTCACTG	0.498000													43	81					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34826110	34826110	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34826110C>T	ENST00000192788.5	+	14	2148	c.1977C>T	c.(1975-1977)agC>agT	p.S659S	UHRF1BP1_ENST00000452449.2_Silent_p.S659S	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	659										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						GTGGCTTTAGCCTTCTGCACA	0.493000													48	123					0	0	1	0	0
B3GNTL1	146712	broad.mit.edu	37	17	80918997	80918997	+	Missense_Mutation	SNP	G	G	A	rs138531570	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80918997G>A	ENST00000576599.1	-	8	1078	c.328C>T	c.(328-330)Cgc>Tgc	p.R110C	B3GNTL1_ENST00000571954.1_5'UTR|B3GNTL1_ENST00000320865.3_Missense_Mutation_p.R221C			Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	221							transferase activity, transferring glycosyl groups			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	8	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TGGTCCACGCGGATGACGCCG	0.697000													6	15					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17375071	17375071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17375071C>T	ENST00000252597.3	-	2	211	c.38G>A	c.(37-39)gGg>gAg	p.G13E	USHBP1_ENST00000598570.1_5'UTR|USHBP1_ENST00000431146.2_5'UTR	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	13							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						AGCATGCCTCCCTCGCCGGCT	0.657000													11	23					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34096010	34096010	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34096010C>T	ENST00000397527.1	+	32	7617	c.6897C>T	c.(6895-6897)acC>acT	p.T2299T	CEP250_ENST00000342580.4_Silent_p.T2243T	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	2299					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding	p.T2299T(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TGCGGAGTACCTTGGAGCAGG	0.567000													49	100					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103321104	103321104	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103321104G>A	ENST00000233969.2	+	10	2089	c.1947G>A	c.(1945-1947)agG>agA	p.R649R		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	649						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						AAAGCATTAGGAAGGACAGCA	0.512000													23	61					0	0	1	0	0
SERPINA6	866	broad.mit.edu	37	14	94776126	94776126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94776126G>A	ENST00000341584.3	-	3	977	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	277					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TCAGTGCAGCGATGACTGTGT	0.562000													34	89					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170716065	170716065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170716065G>A	ENST00000314251.3	-	10	1370	c.1291C>T	c.(1291-1293)Cca>Tca	p.P431S	SLC2A2_ENST00000382808.4_Missense_Mutation_p.P312S	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	431					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GCAGGACGTGGTCCTTGACTG	0.463000													24	75					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34003130	34003130	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34003130G>A	ENST00000373381.4	-	61	9887	c.9711C>T	c.(9709-9711)tcC>tcT	p.S3237S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3214	Sushi 26.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCAGGAGAAGGAGACAGATG	0.607000													28	74					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761935	92761935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92761935G>A	ENST00000318238.4	-	5	4566	c.3350C>T	c.(3349-3351)tCc>tTc	p.S1117F	SAMD9L_ENST00000411955.1_Missense_Mutation_p.S1117F|SAMD9L_ENST00000437805.1_Missense_Mutation_p.S1117F	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1117										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGAAATATAGGAATTTTTAGG	0.383000													38	131					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1208909	1208909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1208909C>T	ENST00000304460.10	+	2	307	c.251C>T	c.(250-252)cCc>cTc	p.P84L		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	84					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GAGGGCATCCCCCTGCTGTAC	0.667000													29	106					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112813	57112813	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57112813G>A	ENST00000454682.1	-	3	2782	c.2501C>T	c.(2500-2502)tCa>tTa	p.S834L	NACA_ENST00000548563.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGAAGAAATGAAGCTTCAAC	0.507000			T	BCL6	NHL								7	31					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831800	61831800	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61831800G>A	ENST00000280772.1	-	37	9030	c.8839C>T	c.(8839-8841)Cag>Tag	p.Q2947*	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2947					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGGAAGGCTGATCAAGCAAT	0.443000													30	71					0	0	1	0	0
BHMT	635	broad.mit.edu	37	5	78421875	78421875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78421875C>T	ENST00000274353.5	+	6	739	c.632C>T	c.(631-633)tCc>tTc	p.S211F	DMGDH_ENST00000520388.1_Intron|BHMT_ENST00000524080.1_Missense_Mutation_p.S58F	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	211	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding	p.S211Y(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	ACAGGAGCATCCATCATTGGT	0.493000													21	80					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90433383	90433383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90433383C>T	ENST00000394375.3	+	8	851	c.738C>T	c.(736-738)ttC>ttT	p.F246F	LIPF_ENST00000238983.4_Silent_p.F236F|LIPF_ENST00000355843.2_Silent_p.F203F	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	236					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		CACACAACTTCTTTGATCAAT	0.368000													83	154					0	0	1	0	0
FAM53A	152877	broad.mit.edu	37	4	1659150	1659150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1659150G>A	ENST00000308132.6	-	3	313	c.121C>T	c.(121-123)Cct>Tct	p.P41S	FAM53A_ENST00000472884.2_Missense_Mutation_p.P41S|FAM53A_ENST00000461064.1_Missense_Mutation_p.P41S|FAM53A_ENST00000489363.1_Missense_Mutation_p.P41S	NM_001174070.1	NP_001167541.1	Q6NSI3	FA53A_HUMAN	family with sequence similarity 53, member A	41						nucleus		p.P41S(1)		breast(2)|central_nervous_system(2)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			AGCTCCAAAGGGAACAGACGA	0.552000													4	20					0	0	1	0	0
PHF7	51533	broad.mit.edu	37	3	52454938	52454938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52454938C>T	ENST00000327906.3	+	7	1093	c.433C>T	c.(433-435)Cgc>Tgc	p.R145C	PHF7_ENST00000478707.1_Missense_Mutation_p.R145C|PHF7_ENST00000347025.2_Missense_Mutation_p.R145C	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	145						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		TGACAAACATCGCCCAACACA	0.493000													38	94					0	0	1	0	0
LMF2	91289	broad.mit.edu	37	22	50941853	50941853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50941853G>A	ENST00000216080.5	-	14	2184	c.2016C>T	c.(2014-2016)tcC>tcT	p.S672S	LMF2_ENST00000474879.2_Silent_p.S697S|LMF2_ENST00000380796.3_Silent_p.S584S			Q9BU23	LMF2_HUMAN	lipase maturation factor 2	697						endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCGAACTACTGGAGCAGGGGT	0.677000													15	28					0	0	1	0	0
LAMP3	27074	broad.mit.edu	37	3	182841908	182841908	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:182841908G>A	ENST00000265598.3	-	6	1467	c.1212C>T	c.(1210-1212)atC>atT	p.I404I	LAMP3_ENST00000466939.1_Silent_p.I380I	NM_014398.3	NP_055213.2	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	404					cell proliferation	integral to membrane|lysosomal membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(2)	28	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			ACCTTAGGCGGATTTTATAGA	0.453000													50	147					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633463	116633463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:116633463G>A	ENST00000260210.4	-	4	865	c.842C>T	c.(841-843)tCc>tTc	p.S281F	BUD13_ENST00000375445.3_Intron	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	281										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		TCTGGGCAGGGAATAAGTGAC	0.512000													64	112					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219299355	219299355	+	Missense_Mutation	SNP	G	G	A	rs143261714	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219299355G>A	ENST00000248444.5	+	14	1695	c.1607G>A	c.(1606-1608)cGg>cAg	p.R536Q	VIL1_ENST00000392114.2_Missense_Mutation_p.R225Q	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	536	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTCCCAGCGCGGGCCAATTTC	0.567000													31	90					0	0	1	0	0
C2CD2L	9854	broad.mit.edu	37	11	118986957	118986957	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118986957C>T	ENST00000336702.3	+	14	2474	c.2115C>T	c.(2113-2115)ccC>ccT	p.P705P	C2CD2L_ENST00000528586.1_3'UTR	NM_014807.3	NP_055622.3	O14523	C2C2L_HUMAN	C2CD2-like	704						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)	13						ACCCCAGCCCCCAGCTCTGAG	0.597000													14	50					0	0	1	0	0
ZNF568	374900	broad.mit.edu	37	19	37488068	37488068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37488068C>T	ENST00000455427.2	+	9	1612	c.1283C>T	c.(1282-1284)tCa>tTa	p.S428L		NM_001204839.1	NP_001191768.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGTTGTGCCTCACAGCTGAGT	0.428000													3	12					0	0	1	0	0
BAP1	8314	broad.mit.edu	37	3	52439273	52439273	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52439273G>A	ENST00000460680.1	-	11	1440	c.969C>T	c.(967-969)gcC>gcT	p.A323A	BAP1_ENST00000296288.5_Silent_p.A305A	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	323					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.A323fs*71(1)|p.P324fs*7(1)		NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		TGTGGGATGGGGCTTGTGCGC	0.592000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							59	136					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173934254	173934254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173934254G>A	ENST00000367696.2	-	10	1690	c.1339C>T	c.(1339-1341)Cgt>Tgt	p.R447C	RC3H1_ENST00000367694.2_Missense_Mutation_p.R447C|RC3H1_ENST00000258349.4_Missense_Mutation_p.R447C			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	447					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						TTCATTTTACGAAATCTATAT	0.368000													18	56					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10092766	10092766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10092766C>T	ENST00000264828.3	-	32	2520	c.2435G>A	c.(2434-2436)gGa>gAa	p.G812E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	812	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCCTATGGGTCCCAGGGGACC	0.537000													15	45					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28598868	28598868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28598868C>T	ENST00000253063.3	+	4	749	c.428C>T	c.(427-429)cCt>cTt	p.P143L		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	143					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGGTGACCCTGAGTGGCTG	0.622000													21	128					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102811671	102811671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102811671G>A	ENST00000307046.8	-	4	694	c.513C>T	c.(511-513)atC>atT	p.I171I	IGF1_ENST00000456098.1_Intron|IGF1_ENST00000392904.1_Intron|IGF1_ENST00000424202.2_Intron|IGF1_ENST00000337514.6_Intron	NM_001111285.1	NP_001104755.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	171					anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding	p.I171M(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						TCTTTCCTCTGATCTGCAGAC	0.463000													199	379					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113681267	113681267	+	Silent	SNP	C	C	T	rs114751886	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113681267C>T	ENST00000397024.1	+	4	375	c.357C>T	c.(355-357)ctC>ctT	p.L119L	MCF2L_ENST00000535094.2_Intron|MCF2L_ENST00000442652.2_Intron|MCF2L_ENST00000375608.3_Intron|MCF2L_ENST00000434480.2_Intron|MCF2L_ENST00000375597.4_Intron|MCF2L_ENST00000421756.1_Intron|MCF2L_ENST00000375604.2_Intron|MCF2L_ENST00000423482.2_Intron|MCF2L_ENST00000397030.1_Intron|MCF2L_ENST00000375601.3_Intron			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	1055	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CTGATGTGCTCGTCCCAGCCT	0.577000													4	19					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148384333	148384333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148384333G>A	ENST00000515425.1	-	17	3909	c.3808C>T	c.(3808-3810)Ccc>Tcc	p.P1270S	SH3TC2_ENST00000538184.1_3'UTR|SH3TC2_ENST00000512049.1_Missense_Mutation_p.P1263S|SH3TC2_ENST00000502274.1_Missense_Mutation_p.P132S	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1270							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCCGGAGGGCCTGCTGTGC	0.642000													9	24					0	0	1	0	0
LRRC20	55222	broad.mit.edu	37	10	72061139	72061139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72061139G>A	ENST00000355790.4	-	5	1003	c.526C>T	c.(526-528)Ccg>Tcg	p.P176S	LRRC20_ENST00000395011.1_Missense_Mutation_p.P126S|LRRC20_ENST00000358141.2_Missense_Mutation_p.P126S|LRRC20_ENST00000373224.1_Missense_Mutation_p.P176S|LRRC20_ENST00000395010.1_Missense_Mutation_p.P120S	NM_001278212.1|NM_001278214.1|NM_207119.1	NP_001265141.1|NP_001265143.1|NP_997002.1	Q8TCA0	LRC20_HUMAN	leucine rich repeat containing 20	176										endometrium(2)|large_intestine(4)|lung(2)|urinary_tract(1)	9						GCGCCTTCCGGAGACATGAGC	0.647000													24	59					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8993436	8993436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8993436G>A	ENST00000397910.4	-	66	41856	c.41653C>T	c.(41653-41655)Ctg>Ttg	p.L13885L	MUC16_ENST00000380951.5_Silent_p.L526L	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13888	SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGTGGGTCAGCTGGCTCAGC	0.592000													19	216					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160141149	160141149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160141149G>A	ENST00000368081.4	+	11	2071	c.1600G>A	c.(1600-1602)Gag>Aag	p.E534K		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	534					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GAATGGGCAGGAGTACTCAAT	0.512000													25	61					0	0	1	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249615	119249615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:119249615C>T	ENST00000217999.2	-	1	232	c.158G>A	c.(157-159)gGt>gAt	p.G53D	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	53					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						GTGGTTCACACCGCCCTCAGG	0.642000													42	30					0	0	1	0	0
GOLGA2	2801	broad.mit.edu	37	9	131021480	131021480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131021480G>A	ENST00000421699.2	-	19	1994	c.1982C>T	c.(1981-1983)gCc>gTc	p.A661V		NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	661						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						GGCCATCTCGGCCACCGCTTT	0.622000													12	30					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54958995	54958995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54958995G>A	ENST00000273286.5	-	2	417	c.255C>T	c.(253-255)tcC>tcT	p.S85S	CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_Silent_p.S9S|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	85						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		GATTTGAAAGGGAATTGTTGG	0.448000													14	32					0	0	1	0	0
LRPAP1	4043	broad.mit.edu	37	4	3516553	3516553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3516553C>T	ENST00000500728.2	-	7	1083	c.937G>A	c.(937-939)Gac>Aac	p.D313N	LRPAP1_ENST00000296325.5_5'UTR	NM_002337.3	NP_002328.1	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein associated protein 1	313	LDL receptor binding (Potential).				negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		CGCTCGCCGTCGCCCACGCTC	0.647000													19	86					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50163489	50163489	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50163489C>T	ENST00000376025.2	-	0	913							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					AGTGATTTTTCGTTGTGGTGT	0.383000													47	22					0	0	1	0	0
PTTG1	9232	broad.mit.edu	37	5	159851296	159851296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:159851296C>T	ENST00000393964.1	+	3	732	c.329C>T	c.(328-330)gCc>gTc	p.A110V	PTTG1_ENST00000519287.1_3'UTR|PTTG1_ENST00000352433.5_Missense_Mutation_p.A110V|PTTG1_ENST00000520452.1_Missense_Mutation_p.A110V			O95997	PTTG1_HUMAN	pituitary tumor-transforming 1	110					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|chromosome organization|chromosome segregation|DNA repair|mitosis|spermatogenesis|transcription from RNA polymerase II promoter	cytosol|nucleus	cysteine-type endopeptidase inhibitor activity|sequence-specific DNA binding transcription factor activity|SH3 domain binding			breast(1)|large_intestine(1)|lung(4)	6	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.00219)|Epithelial(171;0.00348)|all cancers(165;0.0104)		TCAGATGATGCCTATCCAGAA	0.378000													9	139					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36156555	36156555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:36156555G>A	ENST00000378660.1	+	10	1422	c.1234G>A	c.(1234-1236)Gaa>Aaa	p.E412K	CHDC2_ENST00000313548.4_Missense_Mutation_p.E412K					calponin homology domain containing 2																		TACTCTTTATGAAATTGACTT	0.289000													27	14					0	0	1	0	0
ACSL3	2181	broad.mit.edu	37	2	223795394	223795394	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:223795394C>T	ENST00000357430.3	+	14	2127	c.1596C>T	c.(1594-1596)ggC>ggT	p.G532G	ACSL3_ENST00000392066.3_Silent_p.G532G	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	532					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	TTATTGGGGGCCAAAGTGTGA	0.363000			T	ETV1	prostate								18	31					0	0	1	0	0
VOPP1	81552	broad.mit.edu	37	7	55565347	55565347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55565347G>A	ENST00000285279.5	-	3	350	c.150C>T	c.(148-150)tgC>tgT	p.C50C	VOPP1_ENST00000454227.1_Intron|VOPP1_ENST00000428097.1_5'UTR|VOPP1_ENST00000453256.1_5'UTR|VOPP1_ENST00000418904.1_Silent_p.C33C|VOPP1_ENST00000428648.1_5'UTR|VOPP1_ENST00000471168.1_5'UTR|VOPP1_ENST00000433959.1_Silent_p.C41C|VOPP1_ENST00000427700.1_Silent_p.C48C|VOPP1_ENST00000545390.1_Silent_p.C47C	NM_030796.3	NP_110423.3	Q96AW1	VOPP1_HUMAN	vesicular, overexpressed in cancer, prosurvival protein 1	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity			endometrium(1)|lung(4)	5						CCCGCACACAGCACCTGGAGC	0.637000													17	75					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3030524	3030524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3030524G>A	ENST00000381127.1	+	11	1921	c.1700G>A	c.(1699-1701)gGg>gAg	p.G567E	ARSF_ENST00000359361.2_Missense_Mutation_p.G567E|ARSF_ENST00000537104.1_Missense_Mutation_p.G567E	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	567						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTTGCTGTGGGGTGTTCCCA	0.532000													26	15					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480622	140480622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140480622C>T	ENST00000231130.2	+	1	389	c.389C>T	c.(388-390)tCt>tTt	p.S130F	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		130	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATGACCATTCTCCGGTATTC	0.413000													45	107					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111066773	111066773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111066773C>T	ENST00000550703.2	+	4	830	c.674C>T	c.(673-675)cCt>cTt	p.P225L	TCTN1_ENST00000397655.3_Intron|TCTN1_ENST00000551590.1_Intron|TCTN1_ENST00000377654.3_Intron|TCTN1_ENST00000551555.2_Intron|HVCN1_ENST00000548312.1_Intron|TCTN1_ENST00000397659.4_Intron			Q2MV58	TECT1_HUMAN	tectonic family member 1	0					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						AATATCTTTCCTTGTAAGTTA	0.348000													15	33					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19822386	19822386	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19822386G>A	ENST00000344099.3	-	4	1842	c.1704C>T	c.(1702-1704)ttC>ttT	p.F568F		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	568					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				TGGAAGAAATGAAGGCTTTTC	0.413000													29	69					0	0	1	0	0
GCK	2645	broad.mit.edu	37	7	44228526	44228526	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44228526C>T	ENST00000403799.3	-	1	496	c.27G>A	c.(25-27)gaG>gaA	p.E9E	GCK_ENST00000476008.1_Intron|GCK_ENST00000437084.1_Silent_p.E9E	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	9					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						TCTTGGCGGCCTCCATCCTGG	0.562000													13	29					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92568189	92568189	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:92568189G>A	ENST00000370382.3	+	3	774	c.507G>A	c.(505-507)gaG>gaA	p.E169E	BTBD8_ENST00000540648.1_Silent_p.E169E|BTBD8_ENST00000342818.3_Silent_p.E169E			Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	169						nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		AAATTCCAGAGGATATCAGTG	0.328000													33	76					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317795	30317795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30317795C>T	ENST00000375377.1	-	3	1383	c.1282G>A	c.(1282-1284)Gat>Aat	p.D428N		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	428										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						AACCGTGGATCATCAAAGGGA	0.507000													36	110					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20048142	20048142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:20048142G>A	ENST00000400230.2	-	6	348	c.304C>T	c.(304-306)Ctt>Ttt	p.L102F	TPTE2_ENST00000457266.2_Intron|TPTE2_ENST00000390680.2_Missense_Mutation_p.L65F|TPTE2_ENST00000400103.2_Intron|TPTE2_ENST00000255310.6_Missense_Mutation_p.L65F|TPTE2_ENST00000382977.4_Missense_Mutation_p.L102F|TPTE2_ENST00000382978.1_Missense_Mutation_p.L102F|TPTE2_ENST00000382975.4_Missense_Mutation_p.L102F			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	102						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		GGAATATAAAGTTTGCTGTCA	0.323000													40	109					0	0	1	0	0
SLC10A6	345274	broad.mit.edu	37	4	87744939	87744939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:87744939C>T	ENST00000273905.6	-	6	1183	c.1036G>A	c.(1036-1038)Gag>Aag	p.E346K		NM_197965.2	NP_932069.1	Q3KNW5	SOAT_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 6	346						integral to membrane|plasma membrane	bile acid:sodium symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	9		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		TCATTCACCTCCAAGAAGGCA	0.498000													33	74					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	670560	670560	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:670560C>T	ENST00000266383.5	+	20	2953	c.2940C>T	c.(2938-2940)ttC>ttT	p.F980F		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	980						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGAATTTCTTCCATCATTTCC	0.592000													7	31					0	0	1	0	0
DRGX	644168	broad.mit.edu	37	10	50574376	50574376	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50574376G>A	ENST00000374139.2	-	6	587	c.577C>T	c.(577-579)Ctt>Ttt	p.L193F	DRGX_ENST00000434016.1_Missense_Mutation_p.L198F			C9JW76	C9JW76_HUMAN	dorsal root ganglia homeobox	198					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	11						TAGGTGGGAAGGAAGGAGAGT	0.602000													28	72					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6107481	6107481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6107481C>T	ENST00000409021.3	-	3	792	c.343G>A	c.(343-345)Gcc>Acc	p.A115T	JAKMIP1_ENST00000410077.2_Intron|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.A115T|JAKMIP1_ENST00000409371.3_Intron|JAKMIP1_ENST00000457227.2_Intron|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.A115T	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	115	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTCAGCGTGGCCTGCAGCCGC	0.726000													3	17					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227919421	227919421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227919421G>A	ENST00000396625.3	-	31	2956	c.2749C>T	c.(2749-2751)Ccc>Tcc	p.P917S	COL4A4_ENST00000329662.7_Missense_Mutation_p.P917S	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	917	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CTTTCTCCGGGAAAACCTGGG	0.512000													16	51					0	0	1	0	0
POP4	10775	broad.mit.edu	37	19	30106194	30106194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30106194C>T	ENST00000585603.1	+	7	2872	c.570C>T	c.(568-570)ggC>ggT	p.G190G	POP4_ENST00000591824.1_3'UTR|POP4_ENST00000392279.3_Silent_p.G109G|POP4_ENST00000221770.3_Silent_p.G66G			O95707	RPP29_HUMAN	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)	190					mRNA cleavage|rRNA processing|tRNA processing	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease P activity|RNA binding			breast(1)|endometrium(1)|lung(4)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			AAACCGATGGCTTTATTTCCT	0.383000													23	49					0	0	1	0	0
METTL1	4234	broad.mit.edu	37	12	58163367	58163367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58163367G>A	ENST00000324871.7	-	4	1263	c.554C>T	c.(553-555)gCc>gTc	p.A185V	METTL1_ENST00000257848.7_Silent_p.C123C	NM_005371.5	NP_005362.3	Q9UBP6	TRMB_HUMAN	methyltransferase like 1	185						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding			large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			TAGCACGTAGGCATATTCTGC	0.527000													42	96					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190234050	190234050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190234050C>T	ENST00000367462.3	-	4	794	c.563G>A	c.(562-564)aGg>aAg	p.R188K	FAM5C_ENST00000534846.1_Missense_Mutation_p.R86K|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		188						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGTGCTGTCCCTGTCAATGAA	0.443000													45	99					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51289566	51289566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51289566C>T	ENST00000261842.5	+	18	2496	c.2390C>T	c.(2389-2391)tCa>tTa	p.S797L	AP4E1_ENST00000560508.1_Missense_Mutation_p.S722L	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	797					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		AGAAGGAAATCAAAAGTCAAA	0.323000													24	31					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156629387	156629387	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156629387G>A	ENST00000296518.7	+	5	526		c.e5-1		GUCY1A3_ENST00000393832.3_Splice_Site|GUCY1A3_ENST00000511507.1_Splice_Site|GUCY1A3_ENST00000506455.1_Splice_Site|GUCY1A3_ENST00000513574.1_Splice_Site|GUCY1A3_ENST00000515602.1_Splice_Site|GUCY1A3_ENST00000511108.1_Splice_Site|GUCY1A3_ENST00000455639.2_Splice_Site			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3						blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		AATATTTCCAGGAAATCTTTG	0.264000													27	47					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133698359	133698359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133698359C>T	ENST00000310926.4	-	2	473	c.200G>A	c.(199-201)aGt>aAt	p.S67N	SLCO2A1_ENST00000478651.1_5'UTR|SLCO2A1_ENST00000493729.1_Missense_Mutation_p.S67N	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	67					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						CGATGAAGAACTGGAGAGCCC	0.547000													41	109					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100226899	100226899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100226899C>T	ENST00000524871.1	+	25	3541	c.3251C>T	c.(3250-3252)tCg>tTg	p.S1084L	CNTN5_ENST00000528682.1_Missense_Mutation_p.S1084L|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Missense_Mutation_p.S1084L|CNTN5_ENST00000418526.2_Missense_Mutation_p.S1010L	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	1084					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCCACATCTTCGTCATCAGTC	0.418000													6	20					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37650510	37650510	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37650510C>T	ENST00000399151.3	+	30	5911	c.5826C>T	c.(5824-5826)gcC>gcT	p.A1942A		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1942					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CACTCAGTGCCTACAATGCTC	0.522000													23	120					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26802553	26802553	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26802553G>A	ENST00000376236.4	+	8	1232	c.777G>A	c.(775-777)gaG>gaA	p.E259E		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	259	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TATTTTTGGAGAAAGAGGAGA	0.313000													40	113					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73879550	73879550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73879550C>T	ENST00000342056.2	+	12	2005	c.1607C>T	c.(1606-1608)cCa>cTa	p.P536L	KCNQ5_ENST00000355635.3_Missense_Mutation_p.P518L|KCNQ5_ENST00000355194.4_Missense_Mutation_p.P517L|KCNQ5_ENST00000370398.1_Missense_Mutation_p.P517L|KCNQ5_ENST00000414165.2_Intron|KCNQ5_ENST00000403813.2_Missense_Mutation_p.P508L|KCNQ5_ENST00000402622.2_Missense_Mutation_p.P527L	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	517					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CTCACCCCACCACTTAAAACT	0.403000													6	41					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904255	73904255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73904255C>T	ENST00000342056.2	+	15	2372	c.1974C>T	c.(1972-1974)ctC>ctT	p.L658L	KCNQ5_ENST00000355635.3_Silent_p.L640L|KCNQ5_ENST00000355194.4_Silent_p.L639L|KCNQ5_ENST00000370398.1_Silent_p.L639L|KCNQ5_ENST00000414165.2_Silent_p.L529L|KCNQ5_ENST00000403813.2_Silent_p.L630L|KCNQ5_ENST00000402622.2_Silent_p.L649L	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	639					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CCTCAGCCCTCGCTTTGGCTT	0.473000													6	48					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202710650	202710650	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202710650G>A	ENST00000367265.3	-	19	3954	c.2790C>T	c.(2788-2790)ccC>ccT	p.P930P	KDM5B_ENST00000367264.2_Silent_p.P966P	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	930					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TAAGGGAGCTGGGGTCTAGGC	0.522000													22	41					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133208969	133208969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:133208969G>A	ENST00000320574.5	-	45	6305	c.6262C>T	c.(6262-6264)Cct>Tct	p.P2088S	POLE_ENST00000535270.1_Missense_Mutation_p.P2061S	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	2088					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGGAGGACAGGAAACATCTCT	0.522000								DNA polymerases (catalytic subunits)					9	68					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48124509	48124509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:48124509C>T	ENST00000244043.4	-	10	1480	c.1451G>A	c.(1450-1452)gGt>gAt	p.G484D	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	484					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CTGCATCAGACCGAAGCCGTA	0.602000													13	38					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104174892	104174892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104174892G>A	ENST00000020673.5	-	4	1378	c.852C>T	c.(850-852)tcC>tcT	p.S284S	PSD_ENST00000406432.1_Silent_p.S284S	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	284					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGTCTGTCTCGGAGTACTTGG	0.662000													16	45					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4534035	4534035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4534035C>T	ENST00000381848.3	-	2	132	c.52G>A	c.(52-54)Gac>Aac	p.D18N	CTB-50L17.14_ENST00000586020.1_Silent_p.R35R|PLIN5_ENST00000592610.1_Missense_Mutation_p.D18N|PLIN5_ENST00000586133.1_Missense_Mutation_p.D18N	NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	18						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						ACCTGCTGGTCCTGCTCCCAC	0.612000													5	8					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24528509	24528509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24528509C>T	ENST00000342740.5	+	21	1811	c.1657C>T	c.(1657-1659)Cgg>Tgg	p.R553W	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	553										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GGCAGACTCCCGGCTGAAGCT	0.657000													16	31					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38861371	38861371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38861371C>T	ENST00000409235.3	+	29	3534	c.3419C>T	c.(3418-3420)tCc>tTc	p.S1140F	CATSPERG_ENST00000215069.4_3'UTR|CATSPERG_ENST00000410018.1_Missense_Mutation_p.S1100F	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	1140					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						ATGTTCAGCTCCAGGATGACA	0.562000													26	114					0	0	1	0	0
NDC1	55706	broad.mit.edu	37	1	54262797	54262797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54262797G>A	ENST00000371429.3	-	12	1841	c.1243C>T	c.(1243-1245)Cca>Tca	p.P415S	NDC1_ENST00000537333.1_Missense_Mutation_p.P80S|NDC1_ENST00000540001.1_Missense_Mutation_p.P415S|NDC1_ENST00000234725.8_Missense_Mutation_p.P300S	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		CTAGATTTTGGTGTCTGAAAA	0.428000													32	63					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497486	141497486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141497486G>A	ENST00000264952.2	+	1	497	c.360G>A	c.(358-360)ggG>ggA	p.G120G		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	120	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CTGCCCCGGGGAACCCGCAAC	0.672000													9	33					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119886646	119886646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119886646G>A	ENST00000464295.1	-	10	2123	c.1678C>T	c.(1678-1680)Cct>Tct	p.P560S	GPR156_ENST00000461057.1_Missense_Mutation_p.P556S|GPR156_ENST00000315843.3_Missense_Mutation_p.P560S			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	560						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		GAAGCCTCAGGGCCCAGGCCC	0.587000													57	117					0	0	1	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65209693	65209693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65209693C>T	ENST00000380230.3	+	3	276	c.247C>T	c.(247-249)Ctc>Ttc	p.L83F	ANKDD1A_ENST00000357698.3_Missense_Mutation_p.L83F|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.L83F|ANKDD1A_ENST00000319580.8_Intron|AC069368.3_ENST00000437723.1_Intron|ANKDD1A_ENST00000496660.1_Intron|ANKDD1A_ENST00000491145.1_3'UTR	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	83					signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						GGTAGGGGCCCTCACAGAGGC	0.637000													4	10					0	0	1	0	0
ZNF34	80778	broad.mit.edu	37	8	145999601	145999601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145999601G>A	ENST00000429371.2	-	6	823	c.670C>T	c.(670-672)Cct>Tct	p.P224S	ZNF34_ENST00000343459.4_Missense_Mutation_p.P245S	NM_030580.3	NP_085057.3	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		TTCCCAGTAGGAATTTTCTGA	0.403000													12	25					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38723952	38723952	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:38723952G>A	ENST00000342213.2	-	1	1622	c.1276C>T	c.(1276-1278)Cac>Tac	p.H426Y		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	426						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GGGCTTTCGTGAAAGCAGAGC	0.562000													25	32					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61834595	61834595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61834595C>T	ENST00000280772.1	-	37	6235	c.6044G>A	c.(6043-6045)aGa>aAa	p.R2015K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2015					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TACTTGCACTCTCTCTGGCAG	0.443000													26	115					0	0	1	0	0
OSBPL3	26031	broad.mit.edu	37	7	24874210	24874210	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:24874210C>T	ENST00000313367.2	-	15	2092	c.1641G>A	c.(1639-1641)gtG>gtA	p.V547V	OSBPL3_ENST00000431825.2_Silent_p.V480V|OSBPL3_ENST00000396429.1_Silent_p.V511V|OSBPL3_ENST00000409069.1_Silent_p.V480V|OSBPL3_ENST00000396431.1_Silent_p.V516V|OSBPL3_ENST00000353930.1_Silent_p.V511V|OSBPL3_ENST00000352860.1_Silent_p.V516V	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	547					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						CGTTCAGCTCCACCGGCATGG	0.637000													26	56					0	0	1	0	0
CERK	64781	broad.mit.edu	37	22	47116007	47116007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:47116007G>A	ENST00000216264.8	-	3	467	c.355C>T	c.(355-357)Ctg>Ttg	p.L119L	CERK_ENST00000541677.1_5'UTR	NM_022766.5	NP_073603.2	Q8TCT0	CERK1_HUMAN	ceramide kinase	119	Required for binding to sulfatide and phosphoinositides.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	20		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ATCTCCCGCAGGGTCTGCAGC	0.572000													26	73					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32554771	32554771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32554771C>T	ENST00000286827.3	-	16	3325	c.2854G>A	c.(2854-2856)Gag>Aag	p.E952K	TIAM1_ENST00000541036.1_Missense_Mutation_p.E892K	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	952					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						AGGGGGCTCTCGCCAAGGTCG	0.662000													8	15					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63221455	63221455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:63221455C>T	ENST00000449996.3	+	18	1806	c.1734C>T	c.(1732-1734)tcC>tcT	p.S578S	RGS9_ENST00000443584.3_Silent_p.S578S|RGS9_ENST00000262406.9_Silent_p.S581S	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	581					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						TGGCTCTGTCCTTCAGCAGGT	0.682000													34	156					0	0	1	0	0
PDP2	57546	broad.mit.edu	37	16	66919186	66919186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66919186C>T	ENST00000311765.2	+	2	1333	c.999C>T	c.(997-999)atC>atT	p.I333I	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	333					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GGACGATCATCATGGAGGACA	0.587000													6	47					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2869055	2869055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2869055C>T	ENST00000155840.5	+	16	1961	c.1853C>T	c.(1852-1854)tCc>tTc	p.S618F	KCNQ1_ENST00000526095.1_3'UTR|KCNQ1-AS1_ENST00000440887.2_RNA|KCNQ1_ENST00000335475.5_Missense_Mutation_p.S491F	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	618	Subunits assembly domain.				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CAGCTGCTCTCCTTGCACGGT	0.692000													4	5					0	0	1	0	0
ZNF556	80032	broad.mit.edu	37	19	2877742	2877742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2877742G>A	ENST00000586426.1	+	4	870	c.783G>A	c.(781-783)aaG>aaA	p.K261K	ZNF556_ENST00000307635.2_Silent_p.K262K			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGAGTGCAAGCACTGTGGGA	0.537000													17	42					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21965021	21965021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21965021G>A	ENST00000261200.4	-	34	4172	c.4173C>T	c.(4171-4173)atC>atT	p.I1391I	ABCC9_ENST00000261201.4_Silent_p.I1391I|ABCC9_ENST00000345162.2_Silent_p.I1355I	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1391	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCTGCAGAATGATTGAAAGTC	0.383000													11	112					0	0	1	0	0
SPRYD7	57213	broad.mit.edu	37	13	50505152	50505152	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:50505152A>G	ENST00000361840.3	-	2	328		c.e2+1		SPRYD7_ENST00000378195.2_Intron	NM_020456.2	NP_065189.1	Q5W111	SPRY7_HUMAN	SPRY domain containing 7											haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)	6						CATTATACCAACCTGTGGACT	0.313000													15	49					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166897921	166897921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166897921G>A	ENST00000423058.2	-	13	2252	c.2235C>T	c.(2233-2235)ttC>ttT	p.F745F	SCN1A_ENST00000409050.1_Silent_p.F717F|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Silent_p.F734F|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Silent_p.F745F	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	745						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCCAGATTAAGAATATGTTGG	0.373000													38	126					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56768600	56768600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:56768600C>T	ENST00000381295.2	+	18	2776	c.2428C>T	c.(2428-2430)Cgt>Tgt	p.R810C	EXOC1_ENST00000346134.7_Missense_Mutation_p.R810C|EXOC1_ENST00000349598.6_Missense_Mutation_p.R795C	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	810					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					ACAAGAACTTCGTAAAGTCAT	0.383000													29	59					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10669536	10669536	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:10669536C>T	ENST00000226951.6	-	2	198		c.e2-1		CLNK_ENST00000442825.2_Splice_Site	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker						immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						TCAATTCAGCCTGTGGAAACA	0.478000													4	18					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73045661	73045661	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:73045661G>A	ENST00000545377.1	+	3	209		c.e3-1		ARHGEF28_ENST00000296794.6_Splice_Site|ARHGEF28_ENST00000287898.5_Splice_Site|ARHGEF28_ENST00000437974.1_Splice_Site|ARHGEF28_ENST00000426542.2_Splice_Site|ARHGEF28_ENST00000513042.2_Splice_Site	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		TCCTTTTTCAGGGGCAGATGA	0.418000													16	49					0	0	1	0	0
ZNF579	163033	broad.mit.edu	37	19	56090216	56090216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56090216G>A	ENST00000325421.4	-	2	818	c.790C>T	c.(790-792)Ccg>Tcg	p.P264S		NM_152600.2	NP_689813.2	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		GGGCGTGGCGGGGGCCCCCCT	0.721000													4	15					0	0	1	0	0
MUC13	56667	broad.mit.edu	37	3	124627180	124627180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124627180C>T	ENST00000311075.3	-	11	1388	c.1350G>A	c.(1348-1350)acG>acA	p.T450T		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	450						extracellular region|integral to membrane|plasma membrane		p.T450T(1)		breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						CAATATGCTTCGTTTTGTTAT	0.343000													16	34					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43505518	43505518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43505518C>T	ENST00000400427.1	+	4	779	c.383C>T	c.(382-384)tCc>tTc	p.S128F	UMODL1_ENST00000408989.2_Missense_Mutation_p.S200F|UMODL1_ENST00000400424.1_Missense_Mutation_p.S128F|UMODL1_ENST00000408910.2_Missense_Mutation_p.S200F	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	200	WAP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CTTCTGCATTCCTTGGTAGGT	0.607000													33	177					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21265245	21265245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21265245C>T	ENST00000233242.1	-	3	352	c.225G>A	c.(223-225)agG>agA	p.R75R	APOB_ENST00000399256.4_Silent_p.R75R	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	75	Heparin-binding.|Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGCAGTTGATCCTGGTGGCAC	0.587000													34	89					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64504407	64504407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64504407C>T	ENST00000377494.1	-	8	1835	c.913G>A	c.(913-915)Ggt>Agt	p.G305S	RASGRP2_ENST00000394432.3_Missense_Mutation_p.G305S|RASGRP2_ENST00000377497.3_Missense_Mutation_p.G305S|RASGRP2_ENST00000354024.3_Missense_Mutation_p.G305S			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	305	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGGTGCACACCCAGGATCGGG	0.652000													13	34					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23066116	23066116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23066116G>A	ENST00000246006.4	-	1	861	c.714C>T	c.(712-714)ttC>ttT	p.F238F		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	238					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCTTGCACAGGAAATAATGAC	0.592000													41	131					0	0	1	0	0
DIRAS2	54769	broad.mit.edu	37	9	93375806	93375806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:93375806C>T	ENST00000375765.3	-	2	692	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	102					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity	p.E102K(3)		kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						CAGATTTGTTCGTAGATGGGC	0.592000													10	106					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30026560	30026560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:30026560G>A	ENST00000346128.6	-	12	1908	c.1434C>T	c.(1432-1434)atC>atT	p.I478I	TJP1_ENST00000400011.2_Silent_p.I482I|TJP1_ENST00000545208.2_Silent_p.I478I|TJP1_ENST00000356107.6_Silent_p.I478I	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	478	PDZ 3.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CTTCTCTTATGATATTTGTAA	0.363000													29	77					0	0	1	0	0
ANKRD29	147463	broad.mit.edu	37	18	21209887	21209887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21209887G>A	ENST00000592179.1	-	6	612	c.458C>T	c.(457-459)gCc>gTc	p.A153V	ANKRD29_ENST00000322980.9_Missense_Mutation_p.A153V|ANKRD29_ENST00000284207.7_Missense_Mutation_p.A153V	NM_173505.2	NP_775776.2	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	153										breast(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)	13	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ACCACCTTGGGCAGCTAGGAA	0.438000													4	40					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112958820	112958820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112958820C>T	ENST00000271277.6	+	3	258	c.33C>T	c.(31-33)ctC>ctT	p.L11L	RP4-671G15.2_ENST00000502356.2_RNA	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	11						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGCCTGAACTCCTGACACTAT	0.343000													33	103					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209179022	209179022	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:209179022C>T	ENST00000264380.4	+	14	1859	c.1701C>T	c.(1699-1701)tcC>tcT	p.S567S		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	567					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						ACTTAGAATCCTTATTTAATC	0.373000													30	85					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3147762	3147762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3147762G>A	ENST00000263650.7	-	3	319	c.160C>T	c.(160-162)Ccg>Tcg	p.P54S	OSBPL5_ENST00000525498.1_Missense_Mutation_p.P6S|OSBPL5_ENST00000389989.3_Missense_Mutation_p.P54S|OSBPL5_ENST00000348039.5_Missense_Mutation_p.P54S|OSBPL5_ENST00000542243.1_5'UTR	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	54					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGCAGCGACGGGCCGTTGGGC	0.657000													9	23					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109704794	109704794	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109704794G>A	ENST00000356711.2	+	25	3079	c.2953G>A	c.(2953-2955)Gaa>Aaa	p.E985K	MYO16_ENST00000357550.2_Missense_Mutation_p.E985K|MYO16_ENST00000457511.2_Missense_Mutation_p.E497K	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	985	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AATTATTGGAGAAAACAAGAA	0.313000													27	69					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17749924	17749924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17749924C>T	ENST00000428389.2	-	26	3312	c.3313G>A	c.(3313-3315)Gaa>Aaa	p.E1105K	UNC13A_ENST00000551649.1_Missense_Mutation_p.E1017K|UNC13A_ENST00000552293.1_Missense_Mutation_p.E1017K|UNC13A_ENST00000252773.7_Missense_Mutation_p.E1017K|UNC13A_ENST00000519716.2_Missense_Mutation_p.E1017K|UNC13A_ENST00000550896.1_Missense_Mutation_p.E1015K			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1017	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CTGTACAGTTCATGGCAGTTA	0.542000													4	20					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106208522	106208522	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106208522G>A	ENST00000390548.2	-	0	377																											GTTTTGGGGGGAAGAGGAAGA	0.612000													35	58					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169519217	169519217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169519217C>T	ENST00000367796.3	-	10	1634	c.1433G>A	c.(1432-1434)gGg>gAg	p.G478E	F5_ENST00000546081.1_3'UTR|F5_ENST00000367797.3_Missense_Mutation_p.G478E			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	478	F5/8 type A 2.|Plastocyanin-like 3.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATAGGTTTCCCCTGGTTGAAC	0.353000													38	146					0	0	1	0	0
IL11	3589	broad.mit.edu	37	19	55879603	55879603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55879603C>T	ENST00000264563.2	-	4	466	c.404G>A	c.(403-405)cGg>cAg	p.R135Q	IL11_ENST00000585513.1_Missense_Mutation_p.R135Q|IL11_ENST00000590625.1_Missense_Mutation_p.R56Q	NM_000641.3	NP_000632.1	P20809	IL11_HUMAN	interleukin 11	135					B cell differentiation|fat cell differentiation|megakaryocyte differentiation|negative regulation of hormone secretion|platelet activation|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity|growth factor activity|interleukin-11 receptor binding			large_intestine(1)|skin(1)	2	Breast(117;0.191)	Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)	Oprelvekin(DB00038)	GCGCAGCAGCCGGTCCAGTCG	0.687000													3	2					0	0	1	0	0
C7orf66	154907	broad.mit.edu	37	7	108524513	108524513	+	Missense_Mutation	SNP	C	C	T	rs145510967		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:108524513C>T	ENST00000379007.2	-	1	131	c.77G>A	c.(76-78)aGc>aAc	p.S26N		NM_001024607.1	NP_001019778.1	A4D0T2	CG066_HUMAN	chromosome 7 open reading frame 66	26						integral to membrane				breast(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	15						GCAACTGAGGCTCCAAAGTCT	0.383000													6	46					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111154973	111154973	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111154973C>T	ENST00000280325.4	+	3	327	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	60										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		AGCCCTACTTCCCCCAGGAGC	0.662000													45	87					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24858320	24858320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:24858320G>A	ENST00000424834.2	+	7	2685	c.2212G>A	c.(2212-2214)Ggt>Agt	p.G738S	SPATA13_ENST00000343003.6_Missense_Mutation_p.G57S|SPATA13_ENST00000399949.2_Missense_Mutation_p.G35S|SPATA13_ENST00000382095.4_Missense_Mutation_p.G113S|SPATA13_ENST00000409126.1_Missense_Mutation_p.G35S|SPATA13_ENST00000382108.3_Missense_Mutation_p.G738S			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	113					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GGATGACAACGgtagtgagga	0.493000													17	30					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35242161	35242161	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:35242161T>A	ENST00000408931.3	-	8	1751	c.1225A>T	c.(1225-1227)Agt>Tgt	p.S409C		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	409						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GTGGGGCCACTCCCTTGCATG	0.557000													7	27					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42680109	42680109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42680109C>T	ENST00000358131.5	+	4	810	c.602C>T	c.(601-603)tCa>tTa	p.S201L	TOX2_ENST00000435864.2_Missense_Mutation_p.S70L|TOX2_ENST00000341197.3_Missense_Mutation_p.S192L|TOX2_ENST00000423191.1_Missense_Mutation_p.S150L|TOX2_ENST00000372999.1_Missense_Mutation_p.S150L	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGCTCCCCATCACCGCCGGGG	0.637000													7	24					0	0	1	0	0
CREB3L1	90993	broad.mit.edu	37	11	46334007	46334007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:46334007G>A	ENST00000529193.1	+	6	1336	c.885G>A	c.(883-885)cgG>cgA	p.R295R	CREB3L1_ENST00000288400.3_Silent_p.R295R			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	295					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		AGAGAGTCCGGAGGAAAATCA	0.587000			T	FUS	myxofibrosarcoma								14	16					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692426	135692426	+	Missense_Mutation	SNP	G	G	A	rs138178870	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135692426G>A	ENST00000513104.1	-	2	932	c.650C>T	c.(649-651)tCg>tTg	p.S217L	TRPC7_ENST00000426057.2_Missense_Mutation_p.S217L|TRPC7_ENST00000355180.3_Missense_Mutation_p.S217L	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	217					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTCATGCGCGAGCGCGAGTG	0.612000													14	32					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86954766	86954766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86954766G>A	ENST00000234701.3	+	9	1621	c.1270G>A	c.(1270-1272)Gag>Aag	p.E424K	CLCA1_ENST00000394711.1_Missense_Mutation_p.E424K			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	424	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GTGCTTTAACGAGGTCAAACA	0.468000													16	71					0	0	1	0	0
CACTIN	58509	broad.mit.edu	37	19	3623996	3623996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3623996G>A	ENST00000429344.2	-	2	384	c.332C>T	c.(331-333)cCt>cTt	p.P111L	CACTIN_ENST00000221899.3_Missense_Mutation_p.P43L|CACTIN_ENST00000248420.5_Missense_Mutation_p.P111L	NM_001080543.1	NP_001074012.1			cactin, spliceosome C complex subunit																		TGAGGAGCTAGGAGACCACGA	0.701000													6	15					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596678	179596678	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179596678C>T	ENST00000589042.1	-	58	17148	c.16924G>A	c.(16924-16926)Gaa>Aaa	p.E5642K	TTN_ENST00000342992.6_Missense_Mutation_p.E4398K|TTN_ENST00000591111.1_Missense_Mutation_p.E5325K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5325	Ig-like 37.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTTAAATTCCTTGGTAAAA	0.443000													10	74					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17614117	17614117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:17614117G>A	ENST00000377813.1	-	8	2901	c.2598C>T	c.(2596-2598)gtC>gtT	p.V866V	RRBP1_ENST00000360807.4_Silent_p.V433V|RRBP1_ENST00000455029.2_Silent_p.V207V|RRBP1_ENST00000246043.4_Silent_p.V866V|RRBP1_ENST00000377807.2_Silent_p.V433V			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	866					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						GCAGCTGCAGGACCTGCTTCT	0.637000													7	71					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952570	54952570	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54952570G>A	ENST00000273286.5	-	3	1116	c.954C>T	c.(952-954)gcC>gcT	p.A318A	CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_Silent_p.A242A|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	318						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		CATGGTACTGGGCTGTGATTG	0.517000													80	147					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143093720	143093720	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:143093720G>A	ENST00000367603.2	-	5	2898	c.2156C>T	c.(2155-2157)aCt>aTt	p.T719I	HIVEP2_ENST00000012134.2_Missense_Mutation_p.T719I|HIVEP2_ENST00000367604.1_Missense_Mutation_p.T719I	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	719					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GCCCACAGGAGTGCTTACAAT	0.507000													24	59					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176445	57176445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57176445G>A	ENST00000537055.2	-	2	353	c.122C>T	c.(121-123)gCc>gTc	p.A41V		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						TCCCTTGCAGGCCACGGCCTC	0.597000													16	69					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38793988	38793988	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38793988C>T	ENST00000359357.3	+	27	3507	c.3253C>T	c.(3253-3255)Cga>Tga	p.R1085*	DNAH8_ENST00000441566.1_Nonsense_Mutation_p.R1085*|DNAH8_ENST00000449981.2_Nonsense_Mutation_p.R1302*					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTTACTCTGTCGATATCTGAA	0.328000													16	44					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67304727	67304727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67304727G>A	ENST00000299798.11	+	16	2370	c.2305G>A	c.(2305-2307)Ggg>Agg	p.G769R		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	769					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		GAGTGGGCAGGGGGACCTGGC	0.597000													16	50					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225750837	225750837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:225750837G>A	ENST00000409592.3	-	6	650	c.537C>T	c.(535-537)tcC>tcT	p.S179S	DOCK10_ENST00000258390.7_Silent_p.S185S			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	185							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AGAGCCAGCCGGACTTGAAAA	0.498000													12	119					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67290926	67290926	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67290926C>T	ENST00000299798.11	+	7	1310	c.1245C>T	c.(1243-1245)ctC>ctT	p.L415L		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	415					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CCTTTGCTCTCGTCATCCTAC	0.557000													54	113					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340788	121340788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121340788G>A	ENST00000338040.4	+	3	926	c.512G>A	c.(511-513)gGa>gAa	p.G171E		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	171					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GAAATGGGAGGAGCAGTGGGT	0.493000													16	32					0	0	1	0	0
CARD10	29775	broad.mit.edu	37	22	37891882	37891882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37891882C>T	ENST00000403299.1	-	15	2404	c.2188G>A	c.(2188-2190)Gag>Aag	p.E730K	CARD10_ENST00000251973.5_Missense_Mutation_p.E730K|CARD10_ENST00000406271.3_Missense_Mutation_p.E444K			Q9BWT7	CAR10_HUMAN	caspase recruitment domain family, member 10	730					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					CGAAGGATCTCTTGGGCTTTC	0.622000													18	53					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993545	140993545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140993545C>T	ENST00000285879.4	+	4	641	c.355C>T	c.(355-357)Cct>Tct	p.P119S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	119							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGAGCCCTCCTGAGGGTGA	0.522000										HNSCC(15;0.026)			40	57					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	169997050	169997050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169997050C>T	ENST00000263816.3	-	72	13399	c.13114G>A	c.(13114-13116)Gaa>Aaa	p.E4372K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4372					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATAGGCAGTTCGATGGCTGCA	0.547000													12	29					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125844486	125844486	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125844486C>T	ENST00000393434.2	-	15	2122	c.1773G>A	c.(1771-1773)ggG>ggA	p.G591G	ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000472186.1_Silent_p.G591G|ALDH1L1_ENST00000452905.2_Silent_p.G490G|ALDH1L1_ENST00000273450.3_Silent_p.G601G	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	591	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CCACTGTGTTCCCGGCAGCCA	0.572000													26	74					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32945427	32945427	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32945427C>T	ENST00000340811.4	-	13	2554		c.e13-1		PKP2_ENST00000070846.6_Splice_Site	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2						cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TAAACTGAGCCTTTGGAATAA	0.428000													15	76					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20161138	20161138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:20161138C>T	ENST00000263754.4	+	8	1654	c.1199C>T	c.(1198-1200)tCa>tTa	p.S400L		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	400					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						AATTCAACCTCATCTTCCCTT	0.502000													35	68					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73676009	73676009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73676009G>A	ENST00000339764.1	+	4	1172	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	RP11-167N4.2_ENST00000537019.1_RNA|RP11-167N4.2_ENST00000540886.1_RNA|DNAJB13_ENST00000537753.1_5'UTR	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	141					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					CCCCCAAGTCGAACGGGATCT	0.527000											OREG0021218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	63					0	0	1	0	0
TMPRSS2	7113	broad.mit.edu	37	21	42866339	42866339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42866339G>A	ENST00000398585.3	-	3	353	c.293C>T	c.(292-294)tCc>tTc	p.S98F	TMPRSS2_ENST00000497881.1_Intron|TMPRSS2_ENST00000458356.1_Missense_Mutation_p.S61F|TMPRSS2_ENST00000332149.5_Missense_Mutation_p.S61F	NM_001135099.1	NP_001128571.1	O15393	TMPS2_HUMAN	transmembrane protease, serine 2	61					proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ETV1(34)|TMPRSS2/ETV5_ENST00000306376(5)|TMPRSS2/ERG(3582)|TMPRSS2/ETV4(13)	central_nervous_system(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				GACGGGGTTGGAAGCCTGCGT	0.602000			T	"""ERG, ETV1, ETV4, ETV5"""	prostate								12	40					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26825473	26825473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:26825473G>A	ENST00000541819.2	-	7	945	c.843C>T	c.(841-843)ttC>ttT	p.F281F	GABRB3_ENST00000545868.1_Silent_p.F140F|GABRB3_ENST00000299267.4_Silent_p.F225F|GABRB3_ENST00000311550.5_Silent_p.F225F|GABRB3_ENST00000400188.3_Silent_p.F154F			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	225					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CACCTGTGGCGAAGACAACAT	0.572000													31	63					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214171118	214171118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:214171118G>A	ENST00000366958.4	+	2	1848	c.1240G>A	c.(1240-1242)Gac>Aac	p.D414N	PROX1_ENST00000498508.2_Missense_Mutation_p.D414N|PROX1_ENST00000435016.1_Missense_Mutation_p.D414N|PROX1_ENST00000261454.4_Missense_Mutation_p.D414N	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	414					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GTGCTTTGGCGACGTCATCAT	0.562000													22	112					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85447412	85447412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85447412C>T	ENST00000394573.1	+	7	748	c.546C>T	c.(544-546)ttC>ttT	p.F182F	SLC28A1_ENST00000537624.1_Silent_p.F182F|SLC28A1_ENST00000537703.1_Silent_p.F104F|SLC28A1_ENST00000537216.1_Silent_p.F182F|SLC28A1_ENST00000538177.1_Silent_p.F182F|SLC28A1_ENST00000286749.3_Silent_p.F182F	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	182					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGGTGTCCTTCGCAGGAATCT	0.592000													40	109					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448522	155448522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155448522G>A	ENST00000368346.3	-	3	4778	c.4139C>T	c.(4138-4140)cCa>cTa	p.P1380L	ASH1L_ENST00000392403.3_Missense_Mutation_p.P1380L			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1380	Pro-rich.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ACCATAAGATGGATAGAATCC	0.453000													23	52					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81697929	81697929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81697929G>A	ENST00000372292.3	-	8	847	c.807C>T	c.(805-807)ggC>ggT	p.G269G		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	269	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			GTTTTACAAAGCCTGCTGTCT	0.542000													32	91					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110436354	110436354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110436354C>T	ENST00000506538.2	+	5	1217	c.644C>T	c.(643-645)aCc>aTc	p.T215I	WDR36_ENST00000505303.1_Missense_Mutation_p.T159I|WDR36_ENST00000513710.2_Missense_Mutation_p.T215I	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	215					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		CATCCAAGTACCTACTTGAAT	0.294000													4	56					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66191710	66191710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66191710C>T	ENST00000311034.2	+	7	1525	c.1349C>T	c.(1348-1350)aCc>aTc	p.T450I		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	450					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CATTTGCCCACCCCATCCAGC	0.562000													82	187					0	0	1	0	0
NFKBIB	4793	broad.mit.edu	37	19	39396066	39396066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39396066C>T	ENST00000392079.3	+	3	512	c.414C>T	c.(412-414)ccC>ccT	p.P138P	NFKBIB_ENST00000313582.5_Silent_p.P170P|NFKBIB_ENST00000572515.1_Silent_p.P170P			Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	170					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	8	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			ACCGTACTCCCGACACCAACC	0.657000													28	64					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80718764	80718764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:80718764G>A	ENST00000299564.8	-	2	442	c.287C>T	c.(286-288)cCt>cTt	p.P96L	CDYL2_ENST00000563890.1_Missense_Mutation_p.P96L|CDYL2_ENST00000562812.1_Missense_Mutation_p.P96L|CDYL2_ENST00000566173.1_Missense_Mutation_p.P96L|CDYL2_ENST00000562753.1_5'UTR	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	96						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						GCTCTTTCCAGGATCTGAAGG	0.547000													8	50					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35622914	35622914	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35622914G>A	ENST00000392225.3	-	4	866	c.347C>T	c.(346-348)tCt>tTt	p.S116F	LGI4_ENST00000591633.1_Missense_Mutation_p.S116F|LGI4_ENST00000493050.1_5'UTR|LGI4_ENST00000310123.3_Missense_Mutation_p.S116F			Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	116						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCATTCTTAGAGATGGAGCC	0.607000													5	9					0	0	1	0	0
MYADM	91663	broad.mit.edu	37	19	54377181	54377181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54377181C>T	ENST00000391769.2	+	3	678	c.398C>T	c.(397-399)tCg>tTg	p.S133L	MYADM_ENST00000391768.2_Missense_Mutation_p.S133L|MYADM_ENST00000391771.1_Missense_Mutation_p.S133L|MYADM_ENST00000336967.3_Missense_Mutation_p.S133L|MYADM_ENST00000391770.4_Missense_Mutation_p.S133L	NM_001020821.1	NP_001018657.1	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	133	MARVEL 1.					integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		CACGGCCGTTCGCGGGACCAC	0.652000													34	101					0	0	1	0	0
PDE9A	5152	broad.mit.edu	37	21	44189219	44189219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:44189219G>A	ENST00000291539.6	+	17	1604	c.1544G>A	c.(1543-1545)gGg>gAg	p.G515E	PDE9A_ENST00000398234.3_Missense_Mutation_p.G414E|PDE9A_ENST00000398224.3_Missense_Mutation_p.G388E|PDE9A_ENST00000349112.3_Missense_Mutation_p.G387E|PDE9A_ENST00000398236.3_Missense_Mutation_p.G429E|PDE9A_ENST00000398225.3_Missense_Mutation_p.G474E|PDE9A_ENST00000398227.3_Missense_Mutation_p.G355E|PDE9A_ENST00000539837.1_Missense_Mutation_p.G387E|PDE9A_ENST00000335440.6_Missense_Mutation_p.G413E|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000398229.3_Missense_Mutation_p.G381E|PDE9A_ENST00000335512.4_Missense_Mutation_p.G455E|PDE9A_ENST00000398232.3_Missense_Mutation_p.G448E|PDE9A_ENST00000328862.6_Missense_Mutation_p.G489E|PDE9A_ENST00000380328.2_Missense_Mutation_p.G462E	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	515	Catalytic (By similarity).				platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						GCCCAGATTGGGTTCATCAAG	0.507000													28	51					0	0	1	0	0
HOXB9	3219	broad.mit.edu	37	17	46700315	46700315	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46700315G>A	ENST00000311177.5	-	2	907	c.700C>T	c.(700-702)Cag>Tag	p.Q234*	HOXB7_ENST00000567101.1_Intron|HOXB9_ENST00000550387.1_3'UTR	NM_024017.4	NP_076922.1	P17482	HXB9_HUMAN	homeobox B9	234					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|large_intestine(1)|liver(1)|lung(6)|prostate(1)	12						CGCCGGTTCTGAAACCAGATT	0.463000													8	93					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95107144	95107144	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95107144C>T	ENST00000469935.1	+	0	83					NR_015340.1																						tttctgtaaccttgtgatgtg	0.582000													5	7					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127767930	127767930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:127767930G>A	ENST00000483725.3	-	5	1870	c.1534C>T	c.(1534-1536)Ccc>Tcc	p.P512S	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	512							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		TTCTTGGTGGGATTATCAGGC	0.473000													6	43					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31286972	31286972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31286972C>T	ENST00000544665.3	+	9	1032	c.961C>T	c.(961-963)Ctg>Ttg	p.L321L	ITGAM_ENST00000287497.8_Silent_p.L321L	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	321	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CTTTGAGGCTCTGAAGACCAT	0.557000													5	57					0	0	1	0	0
AL132709.8	0	broad.mit.edu	37	14	101431122	101431122	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101431122G>A	ENST00000423708.3	+	0	736																											CTGGATTGATGATATGATGGC	0.363000													23	51					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38830525	38830525	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38830525C>T	ENST00000449082.2	-	3	391	c.392G>A	c.(391-393)tGg>tAg	p.W131*		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	131					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TAAACTGAACCACCTGAAAGG	0.383000													13	28					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552609	1552609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1552609C>T	ENST00000381605.4	-	3	572	c.508G>A	c.(508-510)Gag>Aag	p.E170K	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000262929.5_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	170	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCATGGGACTCGCAGGTGAAG	0.567000													34	112					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11721000	11721000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11721000C>T	ENST00000389825.3	+	6	924	c.613C>T	c.(613-615)Ctt>Ttt	p.L205F	GREB1_ENST00000263834.5_Intron|GREB1_ENST00000234142.5_Intron|GREB1_ENST00000381486.2_Intron|GREB1_ENST00000381483.2_Intron			Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	0						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCCTGCTCTTCTTTGGGCCAA	0.617000													11	22					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63548115	63548115	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:63548115G>A	ENST00000397968.2	+	12	2769	c.2343G>A	c.(2341-2343)gaG>gaA	p.E781E	CDH7_ENST00000323011.3_Silent_p.E781E	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	781					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				CTGGCCAAGAGAGTTTGTACT	0.373000													16	85					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57757027	57757027	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57757027C>T	ENST00000360716.3	+	12	1743	c.1522C>T	c.(1522-1524)Ccc>Tcc	p.P508S	CCDC135_ENST00000394337.4_Missense_Mutation_p.P508S|CCDC135_ENST00000336825.8_Missense_Mutation_p.P443S			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	508						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						GCCTGGCCACCCCCAGGCTCT	0.597000													24	111					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21157616	21157616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21157616C>T	ENST00000377122.4	-	7	1057	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron|NEBL_ENST00000377119.1_Missense_Mutation_p.E221K	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	221					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TTAGAAGCTTCCACGGCATGT	0.343000													21	198					0	0	1	0	0
DBX1	120237	broad.mit.edu	37	11	20181561	20181561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20181561C>T	ENST00000524983.2	-	1	598	c.310G>A	c.(310-312)Gag>Aag	p.E104K	DBX1_ENST00000227256.3_Missense_Mutation_p.E104K			A6NMT0	DBX1_HUMAN	developing brain homeobox 1	104					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)	21						AACGTCGTCTCGCTGGCAGGG	0.677000													5	12					0	0	1	0	0
PRSS8	5652	broad.mit.edu	37	16	31144657	31144657	+	Silent	SNP	G	G	A	rs143732587	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31144657G>A	ENST00000317508.6	-	3	419	c.156C>T	c.(154-156)gtC>gtT	p.V52V	PRSS8_ENST00000568261.1_Silent_p.V52V	NM_002773.3	NP_002764.1	Q16651	PRSS8_HUMAN	protease, serine, 8	52	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	8						ACTGACCGGCGACTGCACTGC	0.637000													6	48					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151891543	151891543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151891543C>T	ENST00000355193.2	-	29	4707	c.4489G>A	c.(4489-4491)Gac>Aac	p.D1497N	KMT2C_ENST00000262189.6_Missense_Mutation_p.D1497N					lysine (K)-specific methyltransferase 2C																		ACCATTTTGTCTAGTTCAGGA	0.373000													13	117					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81173324	81173324	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81173324G>A	ENST00000394685.3	+	6	883	c.464G>A	c.(463-465)gGa>gAa	p.G155E	KIAA1199_ENST00000356249.5_Missense_Mutation_p.G155E|KIAA1199_ENST00000220244.3_Missense_Mutation_p.G155E			Q8WUJ3	K1199_HUMAN	KIAA1199	155	G8.									breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GAGTTGCATGGACAGAAAAAG	0.502000													39	159					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15917200	15917200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15917200G>A	ENST00000338282.6	-	3	520	c.414C>T	c.(412-414)atC>atT	p.I138I	MYH11_ENST00000576790.1_Silent_p.I138I|MYH11_ENST00000396324.3_Silent_p.I138I|MYH11_ENST00000452625.2_Silent_p.I138I|MYH11_ENST00000300036.5_Silent_p.I138I	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	138	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						ACATGTCGACGATCTTCTCCG	0.552000			T	CBFB	AML								28	62					0	0	1	0	0
TRAP1	10131	broad.mit.edu	37	16	3725373	3725373	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3725373G>A	ENST00000575671.1	-	3	942	c.213C>T	c.(211-213)ttC>ttT	p.F71F	TRAP1_ENST00000246957.5_Silent_p.F280F|TRAP1_ENST00000538171.1_Silent_p.F227F|TRAP1_ENST00000573872.1_5'UTR			Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1	280					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding	p.F280F(1)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(90;0.0261)				GGAAGCTGACGAAGTTGCTGT	0.488000													7	47					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61947987	61947987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61947987C>T	ENST00000422202.1	+	20	2696	c.2628C>T	c.(2626-2628)ttC>ttT	p.F876F	COL20A1_ENST00000326996.6_Silent_p.F869F|COL20A1_ENST00000435874.1_Silent_p.F876F|COL20A1_ENST00000358894.6_Silent_p.F869F			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	869	TSP N-terminal.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CCTCTGCCTTCGGTGGGACCC	0.647000													3	6					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56647797	56647797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56647797C>T	ENST00000389934.3	-	26	4003	c.3886G>A	c.(3886-3888)Gca>Aca	p.A1296T	TEX14_ENST00000240361.8_Missense_Mutation_p.A1302T|TEX14_ENST00000349033.5_Missense_Mutation_p.A1256T	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	1302						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGTCACATGCCTTAACAAGG	0.423000													43	97					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58520251	58520251	+	Splice_Site	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58520251T>A	ENST00000302819.5	-	3	452		c.e3-2		ACOX2_ENST00000459701.2_Splice_Site	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain						bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TGATGCTCTCTGCAGAGGACA	0.498000													24	51					0	0	1	0	0
THOP1	7064	broad.mit.edu	37	19	2790449	2790449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2790449C>T	ENST00000307741.6	+	2	250	c.47C>T	c.(46-48)tCt>tTt	p.S16F		NM_003249.3	NP_003240.1	P52888	THOP1_HUMAN	thimet oligopeptidase 1	16					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|lung(8)|ovary(2)|skin(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACGCAGCATCTCCGTGCTCT	0.602000													39	80					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116055828	116055828	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116055828C>T	ENST00000369271.3	-	19	2719		c.e19-1		AFAP1L2_ENST00000304129.4_Splice_Site|AFAP1L2_ENST00000545353.1_Splice_Site|AFAP1L2_ENST00000491814.1_5'UTR	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2						inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TCTCCCATTCCTAGGGTACCA	0.393000													23	239					0	0	1	0	0
SLPI	6590	broad.mit.edu	37	20	43881651	43881651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43881651G>A	ENST00000338380.2	-	3	406	c.386C>T	c.(385-387)cCt>cTt	p.P129L		NM_003064.2	NP_003055.1	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	129	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			lung(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				ACCTTTCACAGGGGAAACGCA	0.567000													29	88					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171584	150171584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150171584C>T	ENST00000307271.3	+	4	1741	c.1167C>T	c.(1165-1167)atC>atT	p.I389I		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	389						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ATGGTCTCATCCAGAAGTGTA	0.428000													42	173					0	0	1	0	0
SLC19A1	6573	broad.mit.edu	37	21	46950876	46950876	+	Missense_Mutation	SNP	G	G	A	rs56138890		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46950876G>A	ENST00000311124.4	-	4	1111	c.959C>T	c.(958-960)aCg>aTg	p.T320M	SLC19A1_ENST00000380010.4_Missense_Mutation_p.T320M|SLC19A1_ENST00000567670.1_Missense_Mutation_p.T320M|SLC19A1_ENST00000485649.2_Missense_Mutation_p.T280M	NM_194255.2	NP_919231.1	P41440	S19A1_HUMAN	solute carrier family 19 (folate transporter), member 1	320					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GGCGAAGGACGTGATGGCGCC	0.701000													5	14					0	0	1	0	0
ZNF253	56242	broad.mit.edu	37	19	20003140	20003140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20003140C>T	ENST00000589717.1	+	4	1176	c.1084C>T	c.(1084-1086)Cat>Tat	p.H362Y	ZNF253_ENST00000355650.4_Missense_Mutation_p.H286Y	NM_021047.2	NP_066385.2	O75346	ZN253_HUMAN	zinc finger protein 253	362				Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TAAGATACTTCATACTGGAGA	0.383000													10	90					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109677760	109677760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109677760C>T	ENST00000338432.7	+	35	4907	c.4788C>T	c.(4786-4788)ttC>ttT	p.F1596F	ACACB_ENST00000377848.3_Silent_p.F1596F|ACACB_ENST00000377854.5_Silent_p.F1526F|ACACB_ENST00000543201.1_Silent_p.F262F			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1596					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TCCTCAACTTCGTGCCCACTG	0.607000													45	61					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807483	20807483	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20807483T>A	ENST00000601440.1	-	4	1346	c.1200A>T	c.(1198-1200)gaA>gaT	p.E400D	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TGCCACATTCTTCACATTTGT	0.398000													8	116					0	0	1	0	0
RNASE10	338879	broad.mit.edu	37	14	20979118	20979118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20979118G>A	ENST00000430083.1	+	2	976	c.572G>A	c.(571-573)gGg>gAg	p.G191E	RNASE10_ENST00000328444.5_Missense_Mutation_p.G163E			Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	163						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	12	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		GAGCTCAAGGGGGGAAAATGT	0.473000													20	48					0	0	1	0	0
DBN1	1627	broad.mit.edu	37	5	176885201	176885201	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176885201T>G	ENST00000292385.5	-	13	2249	c.1640A>C	c.(1639-1641)gAc>gCc	p.D547A	DBN1_ENST00000393563.4_Missense_Mutation_p.D277A|DBN1_ENST00000512501.1_Missense_Mutation_p.D277A|DBN1_ENST00000393565.1_Missense_Mutation_p.D591A|DBN1_ENST00000309007.5_Missense_Mutation_p.D545A	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	545					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCTCTGGGTCACAGAAGGT	0.652000													10	64					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91779643	91779643	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91779643C>T	ENST00000389857.6	-	15	2603	c.2517G>A	c.(2515-2517)aaG>aaA	p.K839K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	839					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				GCTTGGCCTCCTTCTCCAGCA	0.627000													31	94					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35763096	35763096	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:35763096G>A	ENST00000187397.4	+	14	1451		c.e14-1		ARPP21_ENST00000458225.1_Splice_Site|ARPP21_ENST00000417925.1_Splice_Site|ARPP21_ENST00000444190.1_Splice_Site|ARPP21_ENST00000337271.5_Splice_Site	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa							cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						TCGTACTCCAGGGGCAACAGA	0.527000													5	22					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65220510	65220510	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65220510C>T	ENST00000389722.3	-	32	6400	c.6345_splice	c.e32-1	p.G2116_splice	SPTB_ENST00000342835.4_5'UTR|SPTB_ENST00000556626.1_Splice_Site_p.G2116_splice	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	0					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTCTTCTTCCCCCTGCTCAGG	0.597000													20	63					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43221192	43221192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43221192C>T	ENST00000255226.6	+	8	1826	c.1010C>T	c.(1009-1011)cCc>cTc	p.P337L	SLC14A2_ENST00000586448.1_Missense_Mutation_p.P337L	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	337						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTGGCCACACCCTTCGAGACC	0.572000													19	42					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609614	84609614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84609614G>A	ENST00000344803.2	+	4	4276	c.4229G>A	c.(4228-4230)aGg>aAg	p.R1410K		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AAAGACACTAGGGAGTTCCTA	0.498000													7	17					0	0	1	0	0
GAGE2A	729447	broad.mit.edu	37	X	49355801	49355801	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:49355801C>T	ENST00000362097.1	+	3	166	c.81_splice	c.e3-1	p.P28_splice		NM_001127212.1	NP_001120684.1			G antigen 2A											endometrium(4)	4	Ovarian(276;0.236)					ATTCCCCAGCCCGAGCAGTTC	0.438000													100	425					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18113665	18113665	+	Missense_Mutation	SNP	G	G	A	rs150320186		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18113665G>A	ENST00000403915.1	+	3	1841	c.1390G>A	c.(1390-1392)Gat>Aat	p.D464N	KCNS3_ENST00000304101.4_Missense_Mutation_p.D464N|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	464					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity	p.D464N(3)		endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TGTGGTGAGCGATCCTGACTC	0.453000													36	74					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14548453	14548453	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14548453C>T	ENST00000273083.3	-	0	2318							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						TCACTGGTCTCACTGAGGCTG	0.607000													4	14					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121379469	121379469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121379469G>A	ENST00000297848.3	+	46	5407	c.5137G>A	c.(5137-5139)Ggc>Agc	p.G1713S	COL14A1_ENST00000309791.4_Missense_Mutation_p.G1713S|COL14A1_ENST00000247781.3_Missense_Mutation_p.G1618S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1713	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AGGTCCAAGAGGCCCCCCTGG	0.373000													15	45					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168278043	168278043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168278043C>T	ENST00000367821.3	+	7	1031	c.980C>T	c.(979-981)tCc>tTc	p.S327F	TBX19_ENST00000465440.1_3'UTR	NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	327					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					AGCTGGACTTCCTTATCCTCC	0.473000													35	115					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131744851	131744851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131744851C>T	ENST00000372577.2	+	16	1561	c.1540C>T	c.(1540-1542)Cct>Tct	p.P514S		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	514					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						CCTTCGCATACCTCAAGGCAC	0.428000													26	80					0	0	1	0	0
SULT1C4	27233	broad.mit.edu	37	2	108998338	108998338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108998338G>A	ENST00000272452.2	+	2	616	c.290G>A	c.(289-291)gGa>gAa	p.G97E	SULT1C4_ENST00000409309.3_Missense_Mutation_p.G97E	NM_006588.2	NP_006579.2	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member 4	97					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						CCATCCTTAGGATCTGGTGAG	0.373000													18	76					0	0	1	0	0
OPN4	94233	broad.mit.edu	37	10	88418324	88418324	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88418324C>T	ENST00000372071.2	+	5	768	c.541C>T	c.(541-543)Ctg>Ttg	p.L181L	OPN4_ENST00000241891.5_Silent_p.L170L	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	170					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						GGACCGCTACCTGGTAATCAC	0.612000													13	69					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44488448	44488448	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44488448G>A	ENST00000425708.2	-	7	3056	c.2715C>T	c.(2713-2715)ttC>ttT	p.F905F	ZNF445_ENST00000396077.2_Silent_p.F905F			P59923	ZN445_HUMAN	zinc finger protein 445	905					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GTCTCCCAATGAACTCTTTCC	0.483000													40	92					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111311669	111311669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111311669C>T	ENST00000308208.5	+	5	635	c.393C>T	c.(391-393)atC>atT	p.I131I	CCDC63_ENST00000550317.1_3'UTR|CCDC63_ENST00000552694.1_Silent_p.I52I|CCDC63_ENST00000545036.1_Silent_p.I91I	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	131										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						AAAAAAAAATCGCAAACCAAA	0.403000													30	64					0	0	1	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148747925	148747925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148747925C>T	ENST00000514349.1	+	5	1502	c.923C>T	c.(922-924)tCc>tTc	p.S308F	PCYOX1L_ENST00000274569.4_Missense_Mutation_p.S398F			Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like	398					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	p.S398F(1)		breast(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGTCCAGTCCCCCAAGCCC	0.597000											OREG0016912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	156					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663986	169663986	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169663986C>T	ENST00000483289.2	-	0	3308				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						CATACAAAGCCCTCGGCATGC	0.498000													9	110					0	0	1	0	0
RAB9BP1	9366	broad.mit.edu	37	5	104435525	104435525	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:104435525C>T	ENST00000522464.1	-	0	68				RP11-6N13.1_ENST00000503650.1_lincRNA																							CAAAAGCTTTCCTTTTGTAAT	0.413000													13	41					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201012658	201012658	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201012658C>T	ENST00000362061.3	-	40	5025	c.4797_splice	c.e40-1	p.R1600_splice	CACNA1S_ENST00000367338.3_Splice_Site_p.R1581_splice	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1600					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GCCTCCAGTCCTCTAGGGGCA	0.577000											OREG0014067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	59					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192078283	192078283	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:192078283C>T	ENST00000454309.2	-	2	1069	c.244G>A	c.(244-246)Gga>Aga	p.G82R	FGF12_ENST00000430714.1_Intron|FGF12_ENST00000450716.1_Missense_Mutation_p.G20R|FGF12_ENST00000264730.3_Missense_Mutation_p.G20R|FGF12_ENST00000445105.1_Missense_Mutation_p.G20R	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	82					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		AGGAAGTATCCCTGCTGGCTG	0.398000													28	61					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74276934	74276934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74276934C>T	ENST00000262765.5	-	9	4045	c.3866G>A	c.(3865-3867)cGg>cAg	p.R1289Q		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1289							protein binding	p.R1289Q(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CTGTTTCTGCCGATGGTCCTC	0.622000													22	62					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85952165	85952165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:85952165G>A	ENST00000268638.5	+	7	1166	c.744G>A	c.(742-744)gaG>gaA	p.E248E	IRF8_ENST00000562492.1_Silent_p.E44E	NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	248					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				AGGGCCTGGAGCTGGTGCGCT	0.731000													18	34					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72473587	72473587	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72473587C>T	ENST00000360141.3	+	4	834	c.546C>T	c.(544-546)ctC>ctT	p.L182L	CD300A_ENST00000577511.1_Silent_p.L52L|CD300A_ENST00000392625.3_Silent_p.L69L|CD300A_ENST00000310828.5_Silent_p.L69L|CD300A_ENST00000361933.3_Intron	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	182					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						TCCCGCTGCTCCTCTCCCTGC	0.493000													16	43					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166892662	166892662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166892662G>A	ENST00000423058.2	-	16	3342	c.3325C>T	c.(3325-3327)Ccc>Tcc	p.P1109S	SCN1A_ENST00000409050.1_Missense_Mutation_p.P1081S|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.P1098S|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.P1109S	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1109						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTAAGACTGGGGTTGTTTATG	0.358000													56	114					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190129977	190129977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190129977G>A	ENST00000367462.3	-	7	1236	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	FAM5C_ENST00000534846.1_Silent_p.F233F|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		335						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					ATGTGTTGAGGAAATAATTCA	0.299000													37	84					0	0	1	0	0
UBE2U	148581	broad.mit.edu	37	1	64671346	64671346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:64671346G>A	ENST00000371077.4	+	2	515	c.91G>A	c.(91-93)Gaa>Aaa	p.E31K	UBE2U_ENST00000371076.3_Missense_Mutation_p.E31K			Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)	31							ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(3)|lung(2)|skin(1)	6						GCCTGTAAGTGAAGATATGAT	0.289000													29	72					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248309077	248309077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248309077C>T	ENST00000366476.1	+	1	628	c.628C>T	c.(628-630)Cct>Tct	p.P210S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GATTGTTTTTCCTGTTGCAAT	0.418000													72	344					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92715464	92715464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92715464G>A	ENST00000257068.2	+	2	1081	c.1075G>A	c.(1075-1077)Gca>Aca	p.A359T		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	359					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GCAGCACCAGGCAGATGCTCT	0.592000													20	42					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31624191	31624191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31624191G>A	ENST00000379416.3	-	4	249	c.201C>T	c.(199-201)caC>caT	p.H67H		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	67	2Fe-2S ferredoxin-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGGCAGAAAAGTGGCTAGAAC	0.507000													5	46					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107956544	107956544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:107956544C>T	ENST00000285311.3	-	1	910	c.205G>A	c.(205-207)Ggc>Agc	p.G69S	DKK2_ENST00000513208.1_Intron|DKK2_ENST00000510463.1_Intron	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	69					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		AGGTTTTTGCCCTTCTTACTG	0.577000													11	77					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123989933	123989933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123989933C>T	ENST00000369005.1	+	16	8445	c.8105C>T	c.(8104-8106)tCc>tTc	p.S2702F	TACC2_ENST00000368999.1_Missense_Mutation_p.S792F|TACC2_ENST00000369004.3_Intron|TACC2_ENST00000513429.1_Missense_Mutation_p.S848F|TACC2_ENST00000358010.1_Missense_Mutation_p.S848F|TACC2_ENST00000369000.1_Intron|TACC2_ENST00000515603.1_Intron|TACC2_ENST00000369001.1_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.S2702F|TACC2_ENST00000360561.3_Intron|TACC2_ENST00000515273.1_Intron|TACC2_ENST00000453444.2_Intron|TACC2_ENST00000260733.3_Missense_Mutation_p.S780F	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2702						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCTTTGGCTTCCCGCAGCCAC	0.592000													32	66					0	0	1	0	0
ABHD12	26090	broad.mit.edu	37	20	25287509	25287509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:25287509G>A	ENST00000339157.5	-	10	1182	c.910C>T	c.(910-912)Cct>Tct	p.P304S	ABHD12_ENST00000481556.1_5'UTR|ABHD12_ENST00000376542.3_Missense_Mutation_p.P304S	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	304						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						CTTGTAATAGGATCAAGGAAG	0.378000													8	52					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202490	248202490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248202490C>T	ENST00000366479.2	+	1	1017	c.921C>T	c.(919-921)atC>atT	p.I307I	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTCAGAAAATCTTCTCAGTGA	0.423000													20	100					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15793636	15793636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15793636C>T	ENST00000396353.2	+	10	1824	c.998C>T	c.(997-999)tCg>tTg	p.S333L	NDE1_ENST00000396354.1_Intron|NDE1_ENST00000396355.1_Intron|NDE1_ENST00000342673.5_Intron			Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	333					cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						ATGTCTTCATCGCCGCTGCCG	0.512000													8	16					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49896972	49896972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49896972C>T	ENST00000477224.1	-	11	1763	c.1285G>A	c.(1285-1287)Gcc>Acc	p.A429T	CAMKV_ENST00000488336.1_Missense_Mutation_p.A398T|CAMKV_ENST00000463537.1_Silent_p.Q360Q|CAMKV_ENST00000296471.7_Missense_Mutation_p.A401T|CAMKV_ENST00000467248.1_Missense_Mutation_p.A354T|CAMKV_ENST00000466940.1_Missense_Mutation_p.A355T			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	429	Ala-rich.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCATCAGTGGCTGGAGTAGCG	0.632000													40	72					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730073	96730073	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96730073C>T	ENST00000216629.6	+	3	660	c.54C>T	c.(52-54)ctC>ctT	p.L18L	BDKRB1_ENST00000553356.1_Silent_p.L18L|RP11-404P21.8_ENST00000553811.1_3'UTR|RP11-404P21.3_ENST00000553638.1_RNA|RP11-404P21.8_ENST00000555847.1_3'UTR	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	18					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		AGAGCCAGCTCTTCCCTCAAA	0.517000													12	21					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49898258	49898258	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49898258C>T	ENST00000477224.1	-	8	1144	c.666G>A	c.(664-666)gaG>gaA	p.E222E	CAMKV_ENST00000488336.1_Silent_p.E222E|CAMKV_ENST00000463537.1_Silent_p.E222E|CAMKV_ENST00000296471.7_Silent_p.E194E|CAMKV_ENST00000467248.1_Silent_p.E147E|CAMKV_ENST00000466940.1_Silent_p.E179E			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	222	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CTTCCACCTCCTCATAGAAAG	0.488000													53	134					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924294	188924294	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:188924294C>T	ENST00000326866.4	+	4	741	c.333C>T	c.(331-333)ttC>ttT	p.F111F	ZFP42_ENST00000509524.1_Silent_p.F111F	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	111					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AAAAGGTTTTCGAAGCAAGCT	0.408000													35	87					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400505	40400505	+	Silent	SNP	C	C	T	rs141680440	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:40400505C>T	ENST00000338305.6	-	2	890	c.348G>A	c.(346-348)ggG>ggA	p.G116G		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	116						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGGTGTCCTCCCCAAGGCTTG	0.587000													18	31					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40827457	40827457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40827457G>A	ENST00000396617.3	-	6	681	c.91C>T	c.(91-93)Cgt>Tgt	p.R31C	MKL1_ENST00000402630.1_Missense_Mutation_p.R31C|MKL1_ENST00000407029.1_Missense_Mutation_p.R31C|MKL1_ENST00000355630.3_Missense_Mutation_p.R31C|MKL1_ENST00000402042.1_Missense_Mutation_p.R31C			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	31	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						GGCCGGGAACGAATCTTCCGT	0.473000			T	RBM15	acute megakaryocytic leukemia								94	177					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215844336	215844336	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215844336G>A	ENST00000366943.2	-	64	14497	c.14111C>T	c.(14110-14112)cCt>cTt	p.P4704L	USH2A_ENST00000307340.3_Missense_Mutation_p.P4704L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4704	Fibronectin type-III 32.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTCTGTGAAAGGCAATAGTTC	0.378000										HNSCC(13;0.011)			41	139					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63488441	63488441	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:63488441C>G	ENST00000374852.3	-	14	2158	c.2091G>C	c.(2089-2091)gaG>gaC	p.E697D	MTMR8_ENST00000453546.1_Intron	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	697						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						AGTAGTCTGCCTCCTTGGTGC	0.522000													23	19					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61231327	61231327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61231327G>A	ENST00000382768.1	+	5	679	c.679G>A	c.(679-681)Gtg>Atg	p.V227M	SERPINB12_ENST00000269491.1_Missense_Mutation_p.V207M			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	207			K -> E (in dbSNP:rs35582068).		negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TGAAAACACGGTGGATGCACC	0.408000													8	95					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861395	55861395	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55861395C>T	ENST00000302124.2	+	1	643	c.612C>T	c.(610-612)ttC>ttT	p.F204F	OR8I2_ENST00000560768.1_3'UTR			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					TAGCTGGATTCACTCTTCTTA	0.453000													26	98					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29294507	29294507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29294507C>T	ENST00000331664.5	-	1	2620	c.2621G>A	c.(2620-2622)aGg>aAg	p.R874K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	874					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CCATGTTCTCCTGGTGGGGCC	0.622000													24	68					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837306	82837306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82837306C>T	ENST00000265077.3	+	8	9049	c.8484C>T	c.(8482-8484)ccC>ccT	p.P2828P	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.P1841P|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2828	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CATCATCTCCCCTCACTATCT	0.498000													21	129					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70017033	70017033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70017033C>T	ENST00000355303.5	+	22	2543	c.2238C>T	c.(2236-2238)ttC>ttT	p.F746F	ANO1_ENST00000398543.2_Silent_p.F600F|ANO1_ENST00000538023.1_Silent_p.F746F|ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000530676.1_Silent_p.F600F|ANO1_ENST00000531349.1_Silent_p.F455F	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	746					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TCGCCTCCTTCCCCCTGGCCC	0.587000													6	18					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14756399	14756399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14756399G>A	ENST00000380881.4	-	30	6198	c.5383C>T	c.(5383-5385)Cca>Tca	p.P1795S	FREM1_ENST00000380894.1_Missense_Mutation_p.P330S|FREM1_ENST00000380880.3_Missense_Mutation_p.P1794S|FREM1_ENST00000486223.1_5'UTR|FREM1_ENST00000422223.2_Missense_Mutation_p.P1794S			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1794	Calx-beta.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGTTTAGATGGAATCACGGTG	0.333000													5	10					0	0	1	0	0
SH3GL3	6457	broad.mit.edu	37	15	84237342	84237342	+	Silent	SNP	C	C	T	rs146975595		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84237342C>T	ENST00000324537.5	+	7	765	c.273C>T	c.(271-273)acC>acT	p.T91T	SH3GL3_ENST00000427482.2_Silent_p.T83T|SH3GL3_ENST00000434347.1_Silent_p.T91T|SH3GL3_ENST00000535412.1_Silent_p.T83T			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	83	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						AGGTGAAGACCACAGGATACC	0.468000													28	125					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8530211	8530211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8530211C>T	ENST00000348943.3	+	6	674	c.442C>T	c.(442-444)Cct>Tct	p.P148S	HNRNPM_ENST00000325495.4_Missense_Mutation_p.P148S	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	148	RRM 1.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						GTTTTAGGATCCTGATGGTGA	0.458000													17	176					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51749831	51749831	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51749831C>A	ENST00000395052.3	+	4	2276	c.2042C>A	c.(2041-2043)gCc>gAc	p.A681D	GRM2_ENST00000442933.2_Intron|GRM2_ENST00000475478.1_3'UTR	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	681					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TCACAGGTGGCCATCTGCCTG	0.672000													9	40					0.00829132	0.00829501	1	1	0
SLC38A1	81539	broad.mit.edu	37	12	46598182	46598182	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:46598182G>A	ENST00000398637.5	-	11	1418	c.724C>T	c.(724-726)Caa>Taa	p.Q242*	SLC38A1_ENST00000546893.1_Nonsense_Mutation_p.Q242*|SLC38A1_ENST00000549633.1_5'UTR|SLC38A1_ENST00000549049.1_Nonsense_Mutation_p.Q242*|SLC38A1_ENST00000439706.1_Nonsense_Mutation_p.Q242*|SLC38A1_ENST00000552197.1_Nonsense_Mutation_p.Q242*	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	242					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			CAGGGAATTTGAAATTTCTTG	0.323000													14	136					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095218	167095218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167095218G>A	ENST00000361200.2	+	6	1016	c.850G>A	c.(850-852)Gag>Aag	p.E284K	DUSP27_ENST00000443333.1_Missense_Mutation_p.E284K|DUSP27_ENST00000485151.1_3'UTR|DUSP27_ENST00000271385.5_Missense_Mutation_p.E284K			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	284					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity	p.E284Q(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GGAGAGAGAAGAGGACTATGG	0.617000													11	50					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26108068	26108068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26108068G>A	ENST00000313735.6	-	8	1091	c.858C>T	c.(856-858)ttC>ttT	p.F286F		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	286					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GTACCTGAGTGAATTCCACGT	0.647000													18	38					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043908	56043908	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56043908G>A	ENST00000313033.2	+	1	880	c.794G>A	c.(793-795)gGg>gAg	p.G265E		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					ATTTATCATGGGACAATCCTC	0.413000													65	160					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107646739	107646739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107646739G>A	ENST00000374736.3	-	4	665	c.271C>T	c.(271-273)Ccc>Tcc	p.P91S	ABCA1_ENST00000374733.1_Missense_Mutation_p.P31S|ABCA1_ENST00000423487.2_Missense_Mutation_p.P91S	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	91					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACAACTCCGGGAGCCTCCCCA	0.453000													18	61					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178879114	178879114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:178879114C>T	ENST00000286063.5	-	2	1303	c.986G>A	c.(985-987)cGa>cAa	p.R329Q	PDE11A_ENST00000358450.4_Missense_Mutation_p.R79Q	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	329	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			ATCACTGCTTCGGATAGGCAT	0.373000									Primary Pigmented Nodular Adrenocortical Disease, Familial				26	103					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170663	207170663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207170663G>A	ENST00000374423.3	+	5	1797	c.1411G>A	c.(1411-1413)Gaa>Aaa	p.E471K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	471							nucleic acid binding|zinc ion binding	p.E471*(2)		endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GATTGTTAAAGAAATAAGTCT	0.333000													12	28					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3319150	3319150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3319150C>T	ENST00000336727.3	+	2	2157	c.1253C>T	c.(1252-1254)aCc>aTc	p.T418I	RGS12_ENST00000543385.1_Missense_Mutation_p.T418I|RGS12_ENST00000382788.3_Missense_Mutation_p.T418I|RGS12_ENST00000344733.5_Missense_Mutation_p.T418I	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	418						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AACAACAGCACCAGCAGCAAC	0.617000													31	74					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48695053	48695053	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:48695053G>A	ENST00000236495.5	+	5	551	c.501G>A	c.(499-501)aaG>aaA	p.K167K	RP5-1024N4.4_ENST00000606809.1_RNA|SLC5A9_ENST00000438567.2_Silent_p.K142K|SLC5A9_ENST00000533824.1_Silent_p.K163K|SLC5A9_ENST00000420136.2_Silent_p.K135K	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	142						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						AGTATCTGAAGAAGCGATTTG	0.562000													10	81					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22806109	22806109	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:22806109G>A	ENST00000361524.3	-	4	1921	c.1773C>T	c.(1771-1773)gcC>gcT	p.A591A	ZNF521_ENST00000538137.2_Silent_p.A591A|ZNF521_ENST00000584787.1_Silent_p.A371A	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	591					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TATAATTCAGGGCCAAGGGAA	0.413000			T	PAX5	ALL								26	55					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182108	140182108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140182108C>T	ENST00000522353.2	+	1	1326	c.1326C>T	c.(1324-1326)tcC>tcT	p.S442S	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Silent_p.S442S|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGCGTGTCCGTGGAGGTGG	0.652000													61	133					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156269026	156269026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156269026C>T	ENST00000311277.4	-	14	2116	c.1853G>A	c.(1852-1854)cGa>cAa	p.R618Q	AC097467.2_ENST00000601977.1_RNA|MAP9_ENST00000515654.1_Missense_Mutation_p.R594Q|AC097467.2_ENST00000595229.1_RNA|AC097467.2_ENST00000597939.1_RNA|AC097467.2_ENST00000593387.1_RNA|AC097467.2_ENST00000598252.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	618					cell division|mitosis	cytoplasm|microtubule|spindle		p.R618Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CTTCTGTTTTCGTTCAATTCT	0.338000													3	10					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58342389	58342389	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58342389C>T	ENST00000371015.1	+	5	1157	c.690C>T	c.(688-690)agC>agT	p.S230S	PHACTR3_ENST00000395639.4_Intron|PHACTR3_ENST00000361300.4_Intron|PHACTR3_ENST00000359926.3_Silent_p.S227S|PHACTR3_ENST00000541461.1_Silent_p.S189S|PHACTR3_ENST00000395636.2_Silent_p.S189S|PHACTR3_ENST00000355648.4_Silent_p.S189S	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	230	Pro-rich.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			AGCTCCCCAGCCCCCCACTGC	0.592000													19	38					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711110	20711110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20711110G>A	ENST00000315409.2	+	1	213	c.160G>A	c.(160-162)Gcc>Acc	p.A54T		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A54S(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		GGGAAATGGAGCCATCATCTA	0.448000													32	86					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22134064	22134064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22134064C>T	ENST00000408935.1	+	1	768	c.768C>T	c.(766-768)ttC>ttT	p.F256F		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CATGTATCTTCATCTATACTC	0.507000													20	46					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12343364	12343364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12343364C>T	ENST00000358136.3	+	21	5335	c.5205C>T	c.(5203-5205)gtC>gtT	p.V1735V	VPS13D_ENST00000356315.4_Silent_p.V1735V	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1735					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CTCCTAATGTCTTCCAGTTGT	0.493000													20	70					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55285069	55285069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55285069G>A	ENST00000336077.6	+	3	395	c.355G>A	c.(355-357)Gac>Aac	p.D119N	KIR2DL1_ENST00000291633.7_Missense_Mutation_p.D119N|KIR3DL1_ENST00000541392.1_Intron|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL4_ENST00000396284.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	119					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		TGACCCTCTGGACATCGTGAT	0.522000													106	297					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47241497	47241497	+	Missense_Mutation	SNP	C	C	T	rs145043273		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47241497C>T	ENST00000300404.2	+	8	1053	c.994C>T	c.(994-996)Cgc>Tgc	p.R332C	B4GALNT2_ENST00000393354.2_Missense_Mutation_p.R272C|B4GALNT2_ENST00000504681.1_Missense_Mutation_p.R246C	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	332					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GACTTTCCTCCGCCCCCACAA	0.502000													43	193					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15601415	15601415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:15601415G>A	ENST00000281513.5	-	21	2274	c.2249C>T	c.(2248-2250)tCc>tTc	p.S750F	NBAS_ENST00000441750.1_Missense_Mutation_p.S750F	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	750										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						AAGCAGGTCGGAACCATGGTA	0.418000													20	90					0	0	1	0	0
SCN4B	6330	broad.mit.edu	37	11	118015844	118015844	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118015844G>A	ENST00000324727.4	-	2	308	c.162C>T	c.(160-162)acC>acT	p.T54T	SCN4B_ENST00000529878.1_Intron	NM_001142349.1|NM_174934.3	NP_001135821.1|NP_777594.1	Q8IWT1	SCN4B_HUMAN	sodium channel, voltage-gated, type IV, beta subunit	54	Ig-like C2-type.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.33e-05)|Epithelial(105;0.00126)		AGCTGGAGAAGGTGCAGGGCA	0.557000											OREG0021380	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	146					0	0	1	0	0
ZC3H6	376940	broad.mit.edu	37	2	113089137	113089137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113089137C>T	ENST00000409871.1	+	12	3043	c.2642C>T	c.(2641-2643)cCc>cTc	p.P881L	ZC3H6_ENST00000343936.4_Missense_Mutation_p.P881L	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	881							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						GTGTGGGCTCCCGAAGACTTA	0.428000													12	33					0	0	1	0	0
IL18BP	10068	broad.mit.edu	37	11	71711488	71711488	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71711488C>T	ENST00000497194.2	+	2	1492	c.120C>T	c.(118-120)gcC>gcT	p.A40A	IL18BP_ENST00000404792.1_Silent_p.A40A|IL18BP_ENST00000393705.4_Silent_p.A40A|IL18BP_ENST00000337131.5_Silent_p.A40A|IL18BP_ENST00000393703.4_Silent_p.A40A|IL18BP_ENST00000393707.4_Silent_p.A40A|IL18BP_ENST00000531053.1_Silent_p.A40A|IL18BP_ENST00000260049.5_Silent_p.A40A			O95998	I18BP_HUMAN	interleukin 18 binding protein	40					T-helper 1 type immune response	extracellular region	interleukin-18 binding|receptor antagonist activity	p.A40A(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(1)	7						CCACAGCTGCCACTGCCTCAG	0.607000													35	101					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176812784	176812784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176812784C>T	ENST00000324417.5	+	2	133	c.42C>T	c.(40-42)tcC>tcT	p.S14S	SLC34A1_ENST00000512593.1_Silent_p.S14S	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	14					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGCTGTCTCCCCACTCCCAG	0.622000													6	19					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1212541	1212541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1212541C>T	ENST00000304460.10	+	4	661	c.605C>T	c.(604-606)gCc>gTc	p.A202V		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	202					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTGTGCCTGGCCTGCGCATGG	0.637000													13	145					0	0	1	0	0
SH2B2	10603	broad.mit.edu	37	7	101957774	101957774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101957774C>T	ENST00000536178.1	+	8	1463	c.1418C>T	c.(1417-1419)cCc>cTc	p.P473L	SH2B2_ENST00000306803.8_Missense_Mutation_p.P435L			O14492	SH2B2_HUMAN	SH2B adaptor protein 2	436	SH2.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	9						GCAGGGGGGCCCCGGAACCAC	0.627000													11	19					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48746744	48746744	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48746744G>A	ENST00000285238.8	+	17	2176	c.2096G>A	c.(2095-2097)tGg>tAg	p.W699*		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	699	ABC transporter 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CAGCAGGCATGGATCCAGAAC	0.612000													23	64					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342997	29342997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29342997G>A	ENST00000396806.3	-	1	71	c.68C>T	c.(67-69)cCt>cTt	p.P23L	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						AAAGAAGAAAGGCTGCAGCTC	0.393000													8	61					0	0	1	0	0
ALOX15	246	broad.mit.edu	37	17	4536769	4536769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4536769G>A	ENST00000570836.1	-	10	1284	c.1188C>T	c.(1186-1188)acC>acT	p.T396T	ALOX15_ENST00000293761.3_Silent_p.T396T|ALOX15_ENST00000545513.1_Silent_p.T418T|ALOX15_ENST00000574640.1_Silent_p.T357T			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	396	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	TAATTTCCAGGGTGTATCGCA	0.517000													32	27					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833569	168833569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168833569G>A	ENST00000464456.1	-	7	2727	c.1527C>T	c.(1525-1527)ctC>ctT	p.L509L	MECOM_ENST00000433243.2_Silent_p.L510L|MECOM_ENST00000472280.1_Silent_p.L510L|MECOM_ENST00000392736.3_Silent_p.L509L|MECOM_ENST00000494292.1_Silent_p.L697L|MECOM_ENST00000468789.1_Silent_p.L509L|MECOM_ENST00000264674.3_Silent_p.L574L|MECOM_ENST00000460814.1_Silent_p.L509L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GAAAAAATGGGAGGGGAAACA	0.418000													37	85					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	280286	280286	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:280286G>A	ENST00000538872.1	+	13	3191	c.3073G>A	c.(3073-3075)Gaa>Aaa	p.E1025K	IQSEC3_ENST00000382841.2_Missense_Mutation_p.E722K|IQSEC3_ENST00000326261.4_Missense_Mutation_p.E1025K|IQSEC3_ENST00000537151.1_3'UTR|RP11-598F7.6_ENST00000537295.1_lincRNA			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	1025					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		AGCCAAAAGGGAAGCCGCGCT	0.617000													16	59					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189068247	189068247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189068247C>T	ENST00000332517.3	+	6	1268	c.1128C>T	c.(1126-1128)ttC>ttT	p.F376F	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	376	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GGGACCTGTTCTCACTAATAG	0.527000													21	111					0	0	1	0	0
DEFB115	245929	broad.mit.edu	37	20	29847325	29847325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:29847325G>A	ENST00000400552.1	+	2	157	c.157G>A	c.(157-159)Gag>Aag	p.E53K		NM_001037730.1	NP_001032819.1	Q30KQ5	DB115_HUMAN	defensin, beta 115	53					defense response to bacterium	extracellular region				kidney(1)|lung(3)|ovary(1)|skin(1)	6			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			CAAAGAAATTGAGAGGAAGAA	0.353000													17	39					0	0	1	0	0
DPF2	5977	broad.mit.edu	37	11	65107856	65107856	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65107856C>T	ENST00000528416.1	+	2	166	c.32_splice	c.e2-1	p.L11_splice	DPF2_ENST00000532264.1_Intron|DPF2_ENST00000415073.2_Splice_Site_p.L11_splice|DPF2_ENST00000252268.4_Splice_Site_p.L11_splice	NM_006268.4	NP_006259.1	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	11					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)	23						TTCCCTGCAGCCTTGGGGAGC	0.557000													48	232					0	0	1	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118005533	118005533	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:118005533C>T	ENST00000310754.4	-	1	1203	c.1017G>A	c.(1015-1017)tcG>tcA	p.S339S		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	339					protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						TAGAAGATCTCGACCGTTTCT	0.403000													81	169					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255182	140255182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140255182G>A	ENST00000398631.2	+	1	125	c.125G>A	c.(124-126)gGc>gAc	p.G42D	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAAACACGGCACCTTCGTG	0.677000													29	95					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74489273	74489273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74489273C>T	ENST00000394019.2	-	11	1199	c.802G>A	c.(802-804)Gga>Aga	p.G268R	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000359484.4_Missense_Mutation_p.G204R|SLC4A5_ENST00000358683.4_Missense_Mutation_p.G204R|SLC4A5_ENST00000357822.5_Missense_Mutation_p.G268R|SLC4A5_ENST00000346834.4_Missense_Mutation_p.G268R|SLC4A5_ENST00000377634.4_Missense_Mutation_p.G268R|SLC4A5_ENST00000377632.1_Missense_Mutation_p.G268R|SLC4A5_ENST00000423644.1_Missense_Mutation_p.G268R|SLC4A5_ENST00000483195.1_5'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	268						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CACAGACGTCCGTAATTTGCA	0.597000													7	42					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27169583	27169583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27169583G>A	ENST00000380036.4	+	4	1026	c.584G>A	c.(583-585)gGa>gAa	p.G195E	TEK_ENST00000519097.1_Missense_Mutation_p.G91E|TEK_ENST00000406359.4_Missense_Mutation_p.G195E	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	195					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AGGTATATAGGAGGAAACCTC	0.507000													41	88					0	0	1	0	0
RAD9A	5883	broad.mit.edu	37	11	67161231	67161231	+	Missense_Mutation	SNP	C	C	T	rs144155838	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67161231C>T	ENST00000307980.2	+	5	512	c.419C>T	c.(418-420)tCg>tTg	p.S140L		NM_001243224.1|NM_004584.2	NP_001230153.1|NP_004575.1	Q99638	RAD9A_HUMAN	RAD9 homolog A (S. pombe)	140					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding			lung(7)|upper_aerodigestive_tract(1)	8			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GACCCAGCCTCGTGCCCCCAC	0.657000								Other conserved DNA damage response genes					7	14					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994727	140994727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140994727C>T	ENST00000285879.4	+	4	1823	c.1537C>T	c.(1537-1539)Cct>Tct	p.P513S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	513							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCCAGTCTCCTCTCCAGAT	0.507000										HNSCC(15;0.026)			119	83					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215831647	215831647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215831647G>A	ENST00000272895.7	-	39	6028	c.5809C>T	c.(5809-5811)Ctt>Ttt	p.L1937F	ABCA12_ENST00000389661.4_Missense_Mutation_p.L1619F	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1937					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TAAGCTGGAAGGGAGTGATAG	0.383000													32	62					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48628106	48628106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48628106C>T	ENST00000006658.6	+	11	1331	c.1211C>T	c.(1210-1212)cCc>cTc	p.P404L	SPATA20_ENST00000393244.3_Missense_Mutation_p.P344L|SPATA20_ENST00000356488.4_Missense_Mutation_p.P388L|SPATA20_ENST00000511937.1_3'UTR	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	388					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			GCAGACTCGCCCCCAGAGCGG	0.672000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	103					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38481797	38481797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38481797G>A	ENST00000263409.4	-	20	3356	c.3194C>T	c.(3193-3195)tCc>tTc	p.S1065F	LIFR_ENST00000453190.2_Missense_Mutation_p.S1065F	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	1065					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					AAATTGTCGGGAATTAATGGA	0.388000			T	PLAG1	salivary adenoma								58	156					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30705246	30705246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30705246C>T	ENST00000256246.2	-	1	1362	c.1288G>A	c.(1288-1290)Gaa>Aaa	p.E430K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	430										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GACACTGGTTCATTTTCATTT	0.338000													43	157					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10788473	10788473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10788473G>A	ENST00000283025.2	-	1	329	c.258C>T	c.(256-258)ttC>ttT	p.F86F		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	86					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						TATAGCGAGAGAAGAGTGCGG	0.667000													31	65					0	0	1	0	0
SCARF2	91179	broad.mit.edu	37	22	20780149	20780149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20780149G>A	ENST00000405555.3	-	11	2184	c.2114C>T	c.(2113-2115)tCg>tTg	p.S705L	SCARF2_ENST00000266214.5_Missense_Mutation_p.S710L	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	705	Pro-rich.				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGTATGCGCCGATTTGTCGCT	0.766000													9	13					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3678588	3678588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3678588G>A	ENST00000344754.4	-	8	1978	c.1979C>T	c.(1978-1980)tCc>tTc	p.S660F	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.S660F	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	660	Ig-like C2-type 6.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CATGCGTGGGGAACAGCCCCC	0.622000													32	74					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750359	142750359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142750359G>A	ENST00000418316.1	+	1	943	c.922G>A	c.(922-924)Ggc>Agc	p.G308S		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					GAGGCTGAAAGGCCTTTGCAA	0.542000													10	20					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173873345	173873345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:173873345C>T	ENST00000506823.1	+	10	1964	c.1307C>T	c.(1306-1308)gCt>gTt	p.A436V	GALNTL6_ENST00000508122.1_Missense_Mutation_p.A419V	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	436						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						TTCATGGCTGCTGTGGCCTGG	0.612000													13	36					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17895037	17895037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17895037G>A	ENST00000594202.1	+	25	2498	c.2219G>A	c.(2218-2220)cGa>cAa	p.R740Q	FCHO1_ENST00000597512.1_Missense_Mutation_p.R747Q|FCHO1_ENST00000596536.1_Missense_Mutation_p.R740Q|FCHO1_ENST00000600676.1_Missense_Mutation_p.R740Q|FCHO1_ENST00000539407.1_Missense_Mutation_p.R740Q|FCHO1_ENST00000596951.1_Missense_Mutation_p.R740Q|FCHO1_ENST00000252771.7_Missense_Mutation_p.R740Q|FCHO1_ENST00000595033.1_Missense_Mutation_p.R690Q|FCHO1_ENST00000389133.4_Missense_Mutation_p.R740Q	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	740										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						GTGCTGCTGCGATACCAGGTG	0.657000											OREG0025350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	8					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887209	47887209	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47887209G>A	ENST00000396105.1	-	3	1386	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F	ZNFX1_ENST00000371754.4_Silent_p.F380F|ZNFX1_ENST00000371752.1_Silent_p.F380F	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	380							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AAGGTCTGACGAAATCTTCTC	0.468000													40	83					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3677847	3677847	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3677847G>A	ENST00000344754.4	-	9	2264	c.2265C>T	c.(2263-2265)ccC>ccT	p.P755P	SIGLEC1_ENST00000202578.4_Silent_p.P755P	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	755	Ig-like C2-type 7.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CGGTCTCCAGGGGACCCTGGG	0.632000													24	58					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119036026	119036026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119036026C>T	ENST00000296499.5	+	4	1538	c.1135C>T	c.(1135-1137)Cct>Tct	p.P379S	NDST3_ENST00000433996.2_Intron	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	379	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						CTGGTGGTTTCCTCACATGTG	0.443000													23	72					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41525800	41525800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41525800G>A	ENST00000396942.1	-	39	5462	c.5379C>T	c.(5377-5379)ttC>ttT	p.F1793F	ANK1_ENST00000289734.7_Silent_p.F1793F|ANK1_ENST00000347528.4_Silent_p.F1793F|ANK1_ENST00000379758.2_Silent_p.F1793F|ANK1_ENST00000352337.4_Silent_p.F1793F|ANK1_ENST00000265709.8_Silent_p.F1834F|ANK1_ENST00000396945.1_Silent_p.F1793F			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1793	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCACTTGGGTGAAGGTGTTCT	0.652000													33	49					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158326659	158326659	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158326659G>A	ENST00000444681.2	+	5	1136	c.843G>A	c.(841-843)tgG>tgA	p.W281*	CD1E_ENST00000368157.1_Nonsense_Mutation_p.W124*|CD1E_ENST00000452291.2_Nonsense_Mutation_p.W191*|CD1E_ENST00000368165.3_Nonsense_Mutation_p.W290*|CD1E_ENST00000368163.3_Nonsense_Mutation_p.W313*|CD1E_ENST00000368164.3_3'UTR|CD1E_ENST00000368155.3_Nonsense_Mutation_p.W223*|CD1E_ENST00000368154.1_Nonsense_Mutation_p.W136*|CD1E_ENST00000368167.3_Nonsense_Mutation_p.W380*|CD1E_ENST00000368156.1_Nonsense_Mutation_p.W278*|CD1E_ENST00000368161.3_3'UTR|CD1E_ENST00000368160.3_Nonsense_Mutation_p.W368*|CD1E_ENST00000368166.3_Nonsense_Mutation_p.W179*	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	380	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen		p.W380*(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					TGAAGAAGTGGAAGACACGCC	0.428000													26	116					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128494141	128494141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128494141G>A	ENST00000325888.8	+	40	6859	c.6598G>A	c.(6598-6600)Gag>Aag	p.E2200K	FLNC_ENST00000346177.6_Missense_Mutation_p.E2167K|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2200	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GCGGGGCGGGGAGACAAAGCG	0.687000													6	25					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53104213	53104213	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:53104213C>T	ENST00000408890.4	+	1	865	c.849C>T	c.(847-849)ttC>ttT	p.F283F		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	283								p.F283L(1)		endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GGGTCTCCTTCGCCCTCGAGG	0.617000													25	66					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81648080	81648080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81648080C>T	ENST00000558726.1	-	9	1056	c.921G>A	c.(919-921)aaG>aaA	p.K307K	TMC3_ENST00000359440.5_Silent_p.K307K|RP11-761I4.3_ENST00000559781.1_RNA|RP11-761I4.3_ENST00000560851.1_RNA			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	307						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						TTTTGCTTTTCTTTTTCTCCT	0.269000													13	63					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12943017	12943017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12943017G>A	ENST00000235349.5	-	2	269	c.199C>T	c.(199-201)Cct>Tct	p.P67S		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	67										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCTCAGAGGGAGGCGGCGG	0.602000													26	79					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222682	140222682	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140222682G>A	ENST00000531613.1	+	1	1776	c.1776G>A	c.(1774-1776)gcG>gcA	p.A592A	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Silent_p.A592A|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTGGTAGCGAAGGTGCGCG	0.697000													24	24					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39382857	39382857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39382857G>A	ENST00000545653.1	-	9	1671	c.1141C>T	c.(1141-1143)Cct>Tct	p.P381S	DAB2_ENST00000509337.1_Missense_Mutation_p.P381S|DAB2_ENST00000339788.6_Intron|DAB2_ENST00000320816.6_Missense_Mutation_p.P402S	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	402					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			CCTTTGGGAGGGCTTCCCACA	0.507000													29	87					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129744079	129744079	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:129744079G>A	ENST00000446488.3	-	20	2311	c.2208C>T	c.(2206-2208)tcC>tcT	p.S736S	NFRKB_ENST00000304521.5_Silent_p.S736S|NFRKB_ENST00000524746.1_Silent_p.S736S|NFRKB_ENST00000524794.1_Silent_p.S761S	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	736	Pro-rich.|Ser-rich.				DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		CAGGTGGAGGGGAGATGGGAA	0.557000													28	83					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150530026	150530026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150530026G>A	ENST00000271643.4	+	13	2340	c.2104G>A	c.(2104-2106)Gaa>Aaa	p.E702K	RP11-54A4.2_ENST00000442435.2_RNA|ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.E702K|ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.E702K|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.E725K	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	702					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GGAACTGGATGAACGCAGCTG	0.672000													5	8					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10315990	10315990	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10315990G>A	ENST00000403437.2	-	13	1297	c.1203C>T	c.(1201-1203)gcC>gcT	p.A401A	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	401	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GGTAGCAGAGGGCTTTGAGTA	0.498000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				94	133					0	0	1	0	0
CXorf27	25763	broad.mit.edu	37	X	37850185	37850185	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37850185C>T	ENST00000341016.3	+	1	116	c.93C>T	c.(91-93)ttC>ttT	p.F31F	TM4SF2_ENST00000465127.1_Intron	NM_012274.1	NP_036406.1	O75409	HYPM_HUMAN	chromosome X open reading frame 27	31							DNA binding			central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(2)	8						CTAGGAGCTTCGTGGACCGCG	0.458000													5	28					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163513	32163513	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32163513G>A	ENST00000564145.1	-	0	65																											CCTTCGGGGTGATGCCAGTCA	0.547000													18	72					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103051925	103051925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103051925C>T	ENST00000306312.3	-	6	773	c.512G>A	c.(511-513)aGa>aAa	p.R171K	SLC26A5_ENST00000393730.1_Missense_Mutation_p.R171K|SLC26A5_ENST00000432958.2_Missense_Mutation_p.R171K|SLC26A5_ENST00000393729.1_Missense_Mutation_p.R134K|SLC26A5_ENST00000356767.4_Missense_Mutation_p.R171K|SLC26A5_ENST00000339444.6_Missense_Mutation_p.R171K|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000393727.1_Missense_Mutation_p.R171K|SLC26A5_ENST00000393735.2_Missense_Mutation_p.R171K|SLC26A5_ENST00000393723.1_Missense_Mutation_p.R171K	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	171					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CAAGGCATCTCTGGCCTCTGT	0.448000													24	78					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908168	103908168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103908168G>A	ENST00000302259.3	+	1	861	c.618G>A	c.(616-618)ctG>ctA	p.L206L	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	206					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CCGACCCACTGGATCGGGAAG	0.507000													21	91					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2229538	2229538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2229538C>T	ENST00000399655.1	+	3	684	c.419C>T	c.(418-420)gCc>gTc	p.A140V	CACNA1C_ENST00000347598.4_Missense_Mutation_p.A140V|CACNA1C_ENST00000399591.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000480911.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000344100.3_Missense_Mutation_p.A140V|CACNA1C_ENST00000399597.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000335762.5_Missense_Mutation_p.A140V|CACNA1C_ENST00000399595.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399603.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399617.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399606.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399621.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399601.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399638.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399649.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399644.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399629.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000327702.7_Missense_Mutation_p.A140V|CACNA1C_ENST00000399634.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399637.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000406454.3_Missense_Mutation_p.A140V|CACNA1C_ENST00000402845.3_Missense_Mutation_p.A140V|CACNA1C_ENST00000399641.1_Missense_Mutation_p.A140V	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	140					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AATTGTGTGGCCTTAGCGATC	0.403000													29	115					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46338424	46338424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46338424G>A	ENST00000245934.7	-	11	1549	c.1305C>T	c.(1303-1305)acC>acT	p.T435T		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	435					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		ACTCCACGGGGGTGTAGATGG	0.607000													23	83					0	0	1	0	0
C22orf43	51233	broad.mit.edu	37	22	23974157	23974157	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23974157C>T	ENST00000317749.5	-	1	351	c.54G>A	c.(52-54)ggG>ggA	p.G18G	AP000346.2_ENST00000390329.2_RNA	NM_016449.3	NP_057533.2	Q6PGQ1	CV043_HUMAN	chromosome 22 open reading frame 43	18										endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						GTGCGTCCTTCCCCCTGGGCC	0.527000													18	81					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10363550	10363550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10363550C>T	ENST00000255381.2	-	13	1346	c.1236G>A	c.(1234-1236)gaG>gaA	p.E412E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	412	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TGGTTACGAACTCATTGCCGA	0.438000													46	54					0	0	1	0	0
CXCL10	3627	broad.mit.edu	37	4	76943088	76943088	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76943088G>A	ENST00000306602.1	-	4	357	c.292C>T	c.(292-294)Cct>Tct	p.P98S	ART3_ENST00000341029.5_Intron	NM_001565.3	NP_001556.2	P02778	CXL10_HUMAN	chemokine (C-X-C motif) ligand 10	98					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity			kidney(1)|large_intestine(1)|lung(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGGTTTTAAGGAGATCTTTTA	0.453000													50	128					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80772140	80772140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:80772140G>A	ENST00000466387.1	+	14	2048	c.1324G>A	c.(1324-1326)Gaa>Aaa	p.E442K	CTNNA2_ENST00000402739.4_Missense_Mutation_p.E442K|CTNNA2_ENST00000361291.4_Missense_Mutation_p.E476K|CTNNA2_ENST00000496558.1_Missense_Mutation_p.E442K|CTNNA2_ENST00000540488.1_Missense_Mutation_p.E442K|CTNNA2_ENST00000343114.3_Missense_Mutation_p.E121K|CTNNA2_ENST00000541047.1_Missense_Mutation_p.E442K			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	442					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CTCCAACAATGAAGAAGGGGT	0.468000													11	44					0	0	1	0	0
HPR	3250	broad.mit.edu	37	16	72110569	72110569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72110569G>A	ENST00000540303.2	+	5	668	c.636G>A	c.(634-636)aaG>aaA	p.K212K	HPR_ENST00000228226.8_Silent_p.K249K|HPR_ENST00000356967.5_Silent_p.K212K|HPR_ENST00000561690.1_Intron	NM_020995.3	NP_066275.3	P00739	HPTR_HUMAN	haptoglobin-related protein	212	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|stomach(1)|urinary_tract(2)	20		Ovarian(137;0.125)				TACCTTCAAAGAATTATGCAG	0.458000													39	87					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41298734	41298734	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:41298734T>G	ENST00000347132.5	+	11	1644	c.1562T>G	c.(1561-1563)cTc>cGc	p.L521R	KCNQ4_ENST00000509682.2_Missense_Mutation_p.L467R|KCNQ4_ENST00000506017.1_3'UTR	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	521					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			CAGTGTGAGCTCACGGTGGAC	0.602000													14	65					0	0	1	0	0
IGHA2	3494	broad.mit.edu	37	14	106054664	106054664	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106054664G>A	ENST00000390539.2	-	0	68																											GGCATGCGACGACCACGTTCC	0.637000													20	46					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85432029	85432029	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:85432029A>C	ENST00000393217.2	+	2	136	c.75A>C	c.(73-75)gaA>gaC	p.E25D		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	25										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CCTCCTTGGAAAAAGAAGACA	0.373000													11	97					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103701746	103701746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:103701746G>A	ENST00000245312.3	-	5	1408	c.812C>T	c.(811-813)tCc>tTc	p.S271F		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	271					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AACGATGGTGGAACATAGCTG	0.463000													23	72					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97078439	97078439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:97078439C>T	ENST00000524981.3	+	8	1083	c.1083C>T	c.(1081-1083)gcC>gcT	p.A361A				Q6ZTY8	CL063_HUMAN		335										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						TTCTCCAAGCCAGCAATCAAA	0.308000													7	105					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202900660	202900660	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202900660C>T	ENST00000286201.1	+	1	1351	c.1290C>T	c.(1288-1290)ttC>ttT	p.F430F		NM_003507.1	NP_003498.1	O75084	FZD7_HUMAN	frizzled family receptor 7	430					axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						CGCCTCTGTTCGTCTACCTCT	0.627000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	99					0	0	1	0	0
TBCCD1	55171	broad.mit.edu	37	3	186274254	186274254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186274254G>A	ENST00000424280.1	-	4	1282	c.803C>T	c.(802-804)cCa>cTa	p.P268L	TBCCD1_ENST00000446782.1_Missense_Mutation_p.P172L|TBCCD1_ENST00000338733.5_Missense_Mutation_p.P268L	NM_001134415.1	NP_001127887.1	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	268					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		TGTACCAAATGGATTCCCAGT	0.388000													31	61					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53012265	53012265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53012265C>T	ENST00000305748.3	-	1	78	c.44G>A	c.(43-45)gGg>gAg	p.G15E		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	15	Gly-rich.|Head.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTGAAGCCCCCCTTGGCAGC	0.612000													21	80					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233353658	233353658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233353658G>A	ENST00000258229.8	-	12	2912	c.2678C>T	c.(2677-2679)gCc>gTc	p.A893V	PCNXL2_ENST00000430153.1_Missense_Mutation_p.A192V|PCNXL2_ENST00000488780.2_Missense_Mutation_p.A26V	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	893						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TATTGGTGAGGCGGGGTCAGG	0.438000													5	34					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192701045	192701045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:192701045G>A	ENST00000304141.4	-	2	1211	c.882C>T	c.(880-882)ccC>ccT	p.P294P		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	294						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CGAAAGTGAGGGGAGAAACCT	0.473000													61	180					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108626548	108626548	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108626548C>T	ENST00000332082.4	+	8	1838	c.1020C>T	c.(1018-1020)tcC>tcT	p.S340S	WSCD2_ENST00000261400.3_Silent_p.S340S|WSCD2_ENST00000547525.1_Silent_p.S340S|WSCD2_ENST00000549903.1_Silent_p.S340S			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	340						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						CAGGCAAGTCCAAGCAGCTCA	0.562000													13	30					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5529693	5529693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5529693G>A	ENST00000453700.3	-	5	2268	c.2151C>T	c.(2149-2151)gtC>gtT	p.V717V	FBXL18_ENST00000382368.3_Intron			Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	717									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		TTATTCCTGAGACAGCCAGCG	0.493000													5	8					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50253064	50253064	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50253064C>T	ENST00000420502.1	+	0	615							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	TCCAGAACATCGGAGGTAAGA	0.657000													5	55					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56545017	56545017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56545017G>A	ENST00000390649.3	+	9	2557	c.2557G>A	c.(2557-2559)Gat>Aat	p.D853N		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	853						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GAAGGAAGAGGATGTAAGGAT	0.483000													74	199					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75983031	75983031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75983031G>A	ENST00000308508.5	-	3	467	c.375C>T	c.(373-375)gtC>gtT	p.V125V		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	125	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GAAACCCATCGACTGACAACG	0.627000													39	101					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24432489	24432489	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24432489G>A	ENST00000330966.7	-	5	646	c.484C>T	c.(484-486)Cgc>Tgc	p.R162C	MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Missense_Mutation_p.R161C|MYOM3_ENST00000374434.3_Missense_Mutation_p.R161C			Q5VTT5	MYOM3_HUMAN	myomesin 3	161	Ig-like C2-type 1.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCGTGGGAGCGAAGAGGGATC	0.657000													6	62					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764252	92764252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92764252C>T	ENST00000318238.4	-	5	2249	c.1033G>A	c.(1033-1035)Gaa>Aaa	p.E345K	SAMD9L_ENST00000411955.1_Missense_Mutation_p.E345K|SAMD9L_ENST00000437805.1_Missense_Mutation_p.E345K	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	345										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTAGCCCCTTCTCTTACAAAC	0.333000													56	119					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145111140	145111140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145111140C>T	ENST00000426825.1	-	15	2087	c.2006G>A	c.(2005-2007)gGg>gAg	p.G669E	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	669							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CTGGTAGCCCCCCTCAAAGTA	0.637000													18	59					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49063860	49063860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:49063860G>A	ENST00000226432.4	+	16	2236	c.2053G>A	c.(2053-2055)Gaa>Aaa	p.E685K	CWH43_ENST00000513409.1_Missense_Mutation_p.E658K	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	685					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						ACACAATTATGAAAACAACCA	0.259000													20	39					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69961741	69961741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:69961741G>A	ENST00000358913.5	+	18	4137	c.3649G>A	c.(3649-3651)Gag>Aag	p.E1217K	MYPN_ENST00000354393.2_Missense_Mutation_p.E942K|MYPN_ENST00000540630.1_Missense_Mutation_p.E1217K	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	1217	Ig-like 5.|Interaction with ACTN.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						TTGCACCAGAGAGAGGATCAG	0.567000													45	108					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48654502	48654502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48654502G>A	ENST00000263274.7	-	7	980	c.561C>T	c.(559-561)ccC>ccT	p.P187P	LIG1_ENST00000599165.1_5'UTR|LIG1_ENST00000536218.1_Intron|LIG1_ENST00000427526.2_Silent_p.P156P	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	187					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	AGGTCTTTAGGGGCTTGGGAG	0.557000								Nucleotide excision repair (NER)					40	157					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153497395	153497395	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:153497395G>A	ENST00000288670.9	+	25	3503	c.3136G>A	c.(3136-3138)Gga>Aga	p.G1046R	FMNL2_ENST00000475377.2_Missense_Mutation_p.G421R	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	1046	DAD.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						TGTATATGAGGGAAAAGATGG	0.413000													12	42					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955846	51955846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51955846C>T	ENST00000321424.3	-	7	1353	c.1287G>A	c.(1285-1287)aaG>aaA	p.K429K	SIGLEC8_ENST00000340550.5_Silent_p.K336K|SIGLEC8_ENST00000430817.1_Silent_p.K320K	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	429					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GGGGAGGCTTCTTCAGGGGGT	0.592000													8	51					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85450471	85450471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:85450471G>A	ENST00000393217.2	+	8	1961	c.1900G>A	c.(1900-1902)Gaa>Aaa	p.E634K		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	634										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		ACAAGAAAAAGAAATTTATTC	0.294000													8	30					0	0	1	0	0
ACVR1C	130399	broad.mit.edu	37	2	158395161	158395161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158395161G>A	ENST00000243349.7	-	8	1640	c.1280C>T	c.(1279-1281)tCg>tTg	p.S427L	ACVR1C_ENST00000335450.7_Missense_Mutation_p.S347L|ACVR1C_ENST00000348328.5_Missense_Mutation_p.S270L|ACVR1C_ENST00000409680.3_Missense_Mutation_p.S377L	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	427	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity	p.S427*(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						TTCCTCTATCGAGGGATCTGA	0.363000													23	99					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179562606	179562606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179562606G>A	ENST00000444136.1	+	3	494	c.244G>A	c.(244-246)Gaa>Aaa	p.E82K	TDRD5_ENST00000367614.1_Missense_Mutation_p.E82K|TDRD5_ENST00000294848.8_Missense_Mutation_p.E82K	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	82	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CATTCCAGATGAATCTACCAA	0.373000													8	33					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870993	13870993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13870993G>A	ENST00000265104.4	-	24	3821	c.3717C>T	c.(3715-3717)ttC>ttT	p.F1239F	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1239	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTTTCTTATTGAATTCTTCAA	0.398000									Kartagener syndrome				29	79					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67508495	67508495	+	Missense_Mutation	SNP	C	C	T	rs76231229	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:67508495C>T	ENST00000382713.5	+	8	1062	c.872C>T	c.(871-873)tCg>tTg	p.S291L		NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	291							insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GGGTTTGGTTCGTCAAAGATG	0.473000													54	128					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135003268	135003268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:135003268C>T	ENST00000304613.3	+	9	1547	c.1526C>T	c.(1525-1527)tCg>tTg	p.S509L	KNDC1_ENST00000368572.2_Missense_Mutation_p.S509L|KNDC1_ENST00000368571.2_Missense_Mutation_p.S444L			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	509	KIND 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TCCTATGACTCGTTCTTTCTG	0.642000													14	32					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62462974	62462974	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:62462974G>A	ENST00000430451.2	+	1	434	c.237G>A	c.(235-237)gaG>gaA	p.E79E	SYT16_ENST00000446982.2_Silent_p.E79E	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	79										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GGAGTCAAGAGGATGCAAATT	0.378000													18	169					0	0	1	0	0
PTPRA	5786	broad.mit.edu	37	20	3016271	3016271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3016271C>T	ENST00000216877.6	+	20	2334	c.1934C>T	c.(1933-1935)tCc>tTc	p.S645F	PTPRA_ENST00000356147.3_Missense_Mutation_p.S645F|PTPRA_ENST00000380393.3_Missense_Mutation_p.S654F|PTPRA_ENST00000425918.2_Missense_Mutation_p.S665F|PTPRA_ENST00000399903.2_Missense_Mutation_p.S654F|PTPRA_ENST00000318266.5_Missense_Mutation_p.S645F|PTPRA_ENST00000358719.4_Missense_Mutation_p.S510F	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	654	Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGACTGGTGTCCTATGGAGAT	0.532000													11	28					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10781819	10781819	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10781819G>T	ENST00000361367.2	+	6	1118	c.692G>T	c.(691-693)tGc>tTc	p.C231F		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	231					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AATTCCAAATGCGTGGGAGCA	0.438000													36	87					1.67305e-13	1.68134e-13	1	1	0
RBM19	9904	broad.mit.edu	37	12	114282476	114282476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:114282476G>A	ENST00000545145.2	-	23	2860	c.2782C>T	c.(2782-2784)Cac>Tac	p.H928Y	RBM19_ENST00000392561.3_Missense_Mutation_p.H928Y|RBM19_ENST00000261741.5_Missense_Mutation_p.H928Y	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	928					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CTCCTACCGTGAAAGTGAGCG	0.657000													4	11					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14465696	14465696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14465696C>T	ENST00000344204.4	+	37	5734	c.5710C>T	c.(5710-5712)Ccg>Tcg	p.P1904S	TRIO_ENST00000537187.1_Missense_Mutation_p.P1904S|TRIO_ENST00000515710.1_3'UTR	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1904					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					CTCCGAAACACCGAGTGCAGC	0.517000													11	97					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92797198	92797198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:92797198G>A	ENST00000377067.3	+	7	1889	c.1517G>A	c.(1516-1518)gGa>gAa	p.G506E		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	506						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GGTTGCGGGGGATCAGGAAGT	0.433000													47	66					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73464826	73464826	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73464826G>A	ENST00000224721.6	+	24	2912	c.2907G>A	c.(2905-2907)cgG>cgA	p.R969R	CDH23_ENST00000299366.7_Silent_p.R1009R	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	964	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACCAGCTGCGGGTGGTGGCCA	0.662000													21	49					0	0	1	0	0
ARHGAP18	93663	broad.mit.edu	37	6	129921871	129921871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:129921871G>A	ENST00000368149.2	-	11	1576	c.1488C>T	c.(1486-1488)tcC>tcT	p.S496S		NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	496	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		GCTGTTCACTGGACTTCAATC	0.363000													27	78					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31286903	31286903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31286903G>A	ENST00000332585.6	+	8	1916	c.1812G>A	c.(1810-1812)ggG>ggA	p.G604G	OSBP2_ENST00000407373.1_Silent_p.G431G|OSBP2_ENST00000535268.1_Silent_p.G148G|OSBP2_ENST00000382310.3_Silent_p.G555G|OSBP2_ENST00000437268.2_Silent_p.G346G|OSBP2_ENST00000401475.1_Silent_p.G237G|OSBP2_ENST00000403222.3_Silent_p.G438G|OSBP2_ENST00000446658.2_Silent_p.G603G	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	604					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						CCATGCTGGGGGAGACCTTCG	0.662000											OREG0026467	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	50					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72520464	72520464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72520464C>T	ENST00000373208.1	+	22	3536	c.3536C>T	c.(3535-3537)tCc>tTc	p.S1179F	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.S1176F	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	1176	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CCTGGAGCATCCTGGAGCATC	0.632000													22	54					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748286	143748286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143748286C>T	ENST00000408906.2	+	1	826	c.792C>T	c.(790-792)tcC>tcT	p.S264S		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CCCCCAAGTCCCGCCACCCTG	0.572000													60	131					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166658	19166658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19166658G>A	ENST00000375371.3	-	6	1976	c.1955C>T	c.(1954-1956)tCt>tTt	p.S652F		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	652					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GATCTGGAAAGAACGCACGGC	0.617000													55	114					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227942792	227942792	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227942792C>T	ENST00000396625.3	-	25	2012	c.1803_splice	c.e25-1	p.G602_splice	COL4A4_ENST00000329662.7_Splice_Site_p.G602_splice	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	602	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTCATGATCCCCCTGGGAATG	0.507000													14	22					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242755875	242755875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242755875C>T	ENST00000391969.2	+	3	905	c.194C>T	c.(193-195)tCc>tTc	p.S65F	NEU4_ENST00000405370.1_Missense_Mutation_p.S65F|NEU4_ENST00000404257.1_Missense_Mutation_p.S77F|NEU4_ENST00000407683.1_Missense_Mutation_p.S65F|NEU4_ENST00000325935.6_Missense_Mutation_p.S78F	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	65						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		GCCGGGGGCTCCGTGCGGGTG	0.751000													3	6					0	0	1	0	0
MCOLN2	255231	broad.mit.edu	37	1	85424379	85424379	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85424379G>A	ENST00000370608.3	-	3	311	c.244C>T	c.(244-246)Cgt>Tgt	p.R82C	MCOLN2_ENST00000531325.1_5'UTR|MCOLN2_ENST00000284027.5_Missense_Mutation_p.R54C	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	82						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		AAACCAAAACGAACAAGCTAA	0.333000													14	47					0	0	1	0	0
CCDC170	80129	broad.mit.edu	37	6	151894528	151894528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:151894528G>A	ENST00000367290.5	+	6	1083	c.994G>A	c.(994-996)Gcc>Acc	p.A332T	CCDC170_ENST00000239374.7_Missense_Mutation_p.A332T			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	332																	GAAAATCGCAGCCCTCCTTAG	0.502000													26	33					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77808752	77808752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:77808752G>A	ENST00000269397.4	-	5	866	c.689C>T	c.(688-690)cCc>cTc	p.P230L		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	230	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CATTCCGTTGGGGGGGCCCTT	0.642000											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	118					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17228395	17228395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:17228395G>A	ENST00000261381.6	-	9	2046	c.1962C>T	c.(1960-1962)tcC>tcT	p.S654S	CTD-2576D5.4_ENST00000567344.1_RNA	NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	654					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGCGGGCAAAGGAGTGGTACA	0.622000													25	72					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68396090	68396090	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68396090G>A	ENST00000297770.4	-	8	966	c.751C>T	c.(751-753)Cga>Tga	p.R251*	CPA6_ENST00000297769.4_Nonsense_Mutation_p.R103*|CPA6_ENST00000518549.1_Nonsense_Mutation_p.R251*	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	251					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			CTCCAAAATCGATCCTAGACA	0.393000													70	138					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16328098	16328098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:16328098G>A	ENST00000244769.4	-	8	1380	c.444C>T	c.(442-444)atC>atT	p.I148I	ATXN1_ENST00000436367.1_Silent_p.I148I	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	148					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CGGTTGGGGGGATCAGCTGTG	0.632000													32	96					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63316460	63316460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:63316460G>A	ENST00000322893.7	-	8	1748	c.1480C>T	c.(1480-1482)Ctc>Ttc	p.L494F	KCNH5_ENST00000420622.2_Missense_Mutation_p.L494F|KCNH5_ENST00000394968.1_Missense_Mutation_p.L436F	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	494					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACCTGATAGAGTTTTAGGAAG	0.393000													42	105					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31896655	31896655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31896655G>A	ENST00000477310.1	+	3	432	c.403G>A	c.(403-405)Ggc>Agc	p.G135S	C2_ENST00000299367.5_Missense_Mutation_p.G135S|CFB_ENST00000456570.1_Intron|C2_ENST00000452323.2_Intron|C2_ENST00000442278.2_Intron|C2_ENST00000469372.1_Intron|CFB_ENST00000556679.1_Intron|C2_ENST00000418949.2_Missense_Mutation_p.G135S			P00751	CFAB_HUMAN	complement factor B	149	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TCGCCCCAACGGCATGTGGGA	0.622000													22	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584010	179584010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179584010G>A	ENST00000589042.1	-	83	24331	c.24107C>T	c.(24106-24108)tCg>tTg	p.S8036L	TTN_ENST00000342992.6_Missense_Mutation_p.S6792L|TTN_ENST00000591111.1_Missense_Mutation_p.S7719L|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7719							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACGTTTTCCGAAAAGCTGGA	0.507000													28	139					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62751905	62751905	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62751905C>T	ENST00000377871.3	-	1	524	c.258G>A	c.(256-258)tgG>tgA	p.W86*	SLC22A6_ENST00000458333.2_Nonsense_Mutation_p.W86*|SLC22A6_ENST00000421062.2_Nonsense_Mutation_p.W86*|SLC22A6_ENST00000360421.4_Nonsense_Mutation_p.W86*	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	86					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						AGGGCAGTCCCCACTGCGGGG	0.637000													21	123					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10465272	10465272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10465272G>A	ENST00000525621.1	-	19	3112	c.2631C>T	c.(2629-2631)gtC>gtT	p.V877V	TYK2_ENST00000264818.6_Silent_p.V877V|TYK2_ENST00000524462.1_Silent_p.V692V	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	877					intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TCACAGTCAAGACGTCAGCAA	0.582000													29	62					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21136298	21136298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21136298G>A	ENST00000269228.5	-	8	1789	c.1235C>T	c.(1234-1236)gCc>gTc	p.A412V	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.A162V	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	412					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGTGAGAGGGGCCCGGATGAT	0.562000													25	53					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63445416	63445416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:63445416G>A	ENST00000453546.1	-	10	1329	c.1240C>T	c.(1240-1242)Ctc>Ttc	p.L414F	ASB12_ENST00000396130.2_Missense_Mutation_p.L30F|ASB12_ENST00000362002.2_Missense_Mutation_p.L39F			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						GCTTGATTGAGAGCCTGCTTC	0.517000													4	15					0	0	1	0	0
SIAH3	283514	broad.mit.edu	37	13	46358047	46358047	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46358047T>A	ENST00000400405.2	-	2	387	c.281A>T	c.(280-282)gAg>gTg	p.E94V		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	94	His-rich.				multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						CAGCCCCGCCTCCtggtggtg	0.692000													17	36					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35802840	35802840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35802840C>T	ENST00000361922.4	+	10	1786	c.1636C>T	c.(1636-1638)Ccc>Tcc	p.P546S	MAG_ENST00000593348.1_3'UTR|MAG_ENST00000392213.3_Missense_Mutation_p.P546S|MAG_ENST00000537831.2_Missense_Mutation_p.P521S	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	546					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GACAGAGAGCCCCAGCTTCTC	0.607000													6	18					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69344659	69344659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69344659C>T	ENST00000305363.4	+	9	1124	c.1060C>T	c.(1060-1062)Cct>Tct	p.P354S		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	354	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						CGCCATAACTCCTAGAATGTT	0.393000													50	185					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51742772	51742772	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51742772G>A	ENST00000262262.4	+	7	945		c.e7-1		CD33_ENST00000600557.1_Splice_Site|CD33_ENST00000421133.2_Splice_Site	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule						cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CTCTCCATAAGAAACACCAGA	0.502000													19	41					0	0	1	0	0
TM4SF19	116211	broad.mit.edu	37	3	196053858	196053858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:196053858C>T	ENST00000446879.1	-	3	372	c.247G>A	c.(247-249)Ggc>Agc	p.G83S	TM4SF19_ENST00000273695.3_Missense_Mutation_p.G83S|TM4SF19_ENST00000454715.1_Intron			Q96DZ7	T4S19_HUMAN	transmembrane 4 L six family member 19	83						integral to membrane				endometrium(2)|kidney(2)|large_intestine(3)|lung(5)	12	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;3.94e-24)|all cancers(36;4.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.53e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		CTGAAGCAGCCGTATCTCCAG	0.512000													8	25					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69283116	69283116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69283116G>A	ENST00000338352.2	+	1	776	c.742G>A	c.(742-744)Gag>Aag	p.E248K		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	248	OTU.									autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						CATCGGGGAGGAGTACGTCAA	0.657000													13	16					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81381515	81381515	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:81381515C>T	ENST00000222390.5	-	5	772	c.546G>A	c.(544-546)ggG>ggA	p.G182G	HGF_ENST00000444829.2_Silent_p.G182G|HGF_ENST00000453411.1_Silent_p.G177G|HGF_ENST00000423064.2_Silent_p.G182G|HGF_ENST00000457544.2_Silent_p.G177G	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	182	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CCCCTTCTTCCCCTCGAGGAT	0.433000													8	103					0	0	1	0	0
HIST1H4C	8364	broad.mit.edu	37	6	26104318	26104318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26104318C>T	ENST00000377803.2	+	1	215	c.143C>T	c.(142-144)tCc>tTc	p.S48F		NM_003542.3	NP_003533.1	P62805	H4_HUMAN	histone cluster 1, H4c	48					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7						AAGCGCATTTCCGGTCTTATC	0.537000													21	53					0	0	1	0	0
CNN1	1264	broad.mit.edu	37	19	11658696	11658696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11658696G>A	ENST00000592923.1	+	6	902	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	CNN1_ENST00000252456.2_Missense_Mutation_p.E159K|CNN1_ENST00000544952.1_Missense_Mutation_p.E139K|CNN1_ENST00000535659.2_Missense_Mutation_p.E109K			P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	159	CH.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9						GAAGCTAAGAGAAGGGCGGAA	0.582000													20	27					0	0	1	0	0
RAB20	55647	broad.mit.edu	37	13	111176459	111176459	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111176459C>T	ENST00000267328.3	-	2	471	c.258G>A	c.(256-258)caG>caA	p.Q86Q		NM_017817.1	NP_060287.1	Q9NX57	RAB20_HUMAN	RAB20, member RAS oncogene family	86					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding			endometrium(2)|large_intestine(2)|lung(3)	7	all_cancers(4;1.54e-11)|all_epithelial(4;1.22e-06)|all_lung(23;1e-05)|Lung NSC(43;0.000453)|Colorectal(4;0.00323)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.197)			CCACCAGGCTCTGCCGGTGAT	0.627000													15	67					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179413153	179413153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179413153C>T	ENST00000589042.1	-	339	93424	c.93200G>A	c.(93199-93201)aGt>aAt	p.S31067N	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S28499N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S29426N|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S22194N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S22127N|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S22002N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29426	Ig-like 139.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATTTTTCACTGATAACCTG	0.483000													56	215					0	0	1	0	0
TTC23	64927	broad.mit.edu	37	15	99740154	99740154	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:99740154G>A	ENST00000394132.2	-	9	1546	c.729C>T	c.(727-729)ctC>ctT	p.L243L	TTC23_ENST00000394130.1_Silent_p.L243L|TTC23_ENST00000394136.1_Silent_p.L243L|TTC23_ENST00000558663.1_Silent_p.L243L|TTC23_ENST00000558613.1_Silent_p.L243L|TTC23_ENST00000394129.2_Silent_p.L243L|TTC23_ENST00000394135.3_Silent_p.L243L|TTC23_ENST00000262074.4_Silent_p.L243L			Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	243							binding			endometrium(2)|large_intestine(3)|lung(9)|urinary_tract(2)	16	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			ATACATCGTGGAGTCCCAGGG	0.468000													79	111					0	0	1	0	0
CAMK2A	815	broad.mit.edu	37	5	149652720	149652720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149652720C>T	ENST00000348628.6	-	2	730	c.65G>A	c.(64-66)gGa>gAa	p.G22E	CAMK2A_ENST00000398376.3_Missense_Mutation_p.G22E	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	22	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGAGAAGGCTCCCCTAGGAGG	0.567000													14	69					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63277357	63277357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63277357C>T	ENST00000415491.2	+	3	977	c.363C>T	c.(361-363)ttC>ttT	p.F121F	LGALS12_ENST00000340246.5_Silent_p.F183F|LGALS12_ENST00000255684.5_Silent_p.F182F|LGALS12_ENST00000425950.2_Silent_p.F121F|LGALS12_ENST00000394618.3_Silent_p.F182F	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	182	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						CTGTTGGATTCCTGAACATCA	0.557000													5	24					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168678418	168678418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168678418G>A	ENST00000519560.1	-	2	662	c.243C>T	c.(241-243)ttC>ttT	p.F81F	SLIT3_ENST00000332966.8_Silent_p.F81F|SLIT3_ENST00000521130.1_5'UTR|SLIT3_ENST00000404867.3_Silent_p.F81F	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	81					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGAGCCCAGCGAAGTCCATCT	0.433000													32	95					0	0	1	0	0
ACVR1B	91	broad.mit.edu	37	12	52370317	52370317	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52370317C>T	ENST00000257963.4	+	3	615	c.538C>T	c.(538-540)Cag>Tag	p.Q180*	ACVR1B_ENST00000426655.2_Nonsense_Mutation_p.Q180*|ACVR1B_ENST00000415850.2_Nonsense_Mutation_p.Q180*|ACVR1B_ENST00000541224.1_Nonsense_Mutation_p.Q180*|ACVR1B_ENST00000542485.1_Nonsense_Mutation_p.Q128*	NM_004302.4|NM_020328.3	NP_004293.1|NP_064733.3	P36896	ACV1B_HUMAN	activin A receptor, type IB	180	GS.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			breast(5)|endometrium(4)|kidney(5)|large_intestine(12)|lung(10)|ovary(1)|pancreas(6)|prostate(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	CAAGACGCTCCAGGATCTTGT	0.502000													16	113					0	0	1	0	0
KRT77	374454	broad.mit.edu	37	12	53086630	53086630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53086630C>T	ENST00000341809.3	-	6	1143	c.1115G>A	c.(1114-1116)gGa>gAa	p.G372E	KRT77_ENST00000537195.1_Missense_Mutation_p.G139E|RP11-641A6.3_ENST00000547533.1_RNA	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	372	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CAGGTCGTCTCCATGTCTCCC	0.587000													16	55					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74275217	74275217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74275217C>T	ENST00000409262.3	+	1	1768	c.1768C>T	c.(1768-1770)Ccc>Tcc	p.P590S		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	590							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTTTGGGCTTCCCGGCCCCCC	0.592000													18	41					0	0	1	0	0
HDAC7	51564	broad.mit.edu	37	12	48190922	48190922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48190922G>A	ENST00000080059.7	-	7	580	c.581C>T	c.(580-582)tCt>tTt	p.S194F	HDAC7_ENST00000427332.2_Missense_Mutation_p.S155F|HDAC7_ENST00000354334.3_Missense_Mutation_p.S194F|HDAC7_ENST00000552960.1_Missense_Mutation_p.S177F|HDAC7_ENST00000380610.4_Missense_Mutation_p.S211F	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	155	Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding	p.S155F(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		GTTGGGCTCAGAGACTGCAGG	0.592000													40	87					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74824584	74824584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74824584G>A	ENST00000256362.4	+	2	1339	c.1098G>A	c.(1096-1098)agG>agA	p.R366R		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	366					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TGCCCCCCAGGGAGGTGCTGG	0.652000													20	35					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24578591	24578591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24578591C>T	ENST00000319715.4	+	15	2149	c.1717C>T	c.(1717-1719)Cct>Tct	p.P573S	RBBP6_ENST00000348022.2_Missense_Mutation_p.P573S|RBBP6_ENST00000381039.3_Intron	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	573					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		ccatacacttcctctccctcc	0.572000													18	192					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42914141	42914141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42914141G>A	ENST00000372565.3	-	3	690	c.421C>T	c.(421-423)Ctt>Ttt	p.L141F	ZMYND12_ENST00000433602.2_Intron	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	141						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CACTCACCAAGGCTGGCCTCG	0.532000													6	21					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24861028	24861028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:24861028C>T	ENST00000424834.2	+	9	3080	c.2607C>T	c.(2605-2607)gtC>gtT	p.V869V	SPATA13_ENST00000343003.6_Silent_p.V188V|SPATA13_ENST00000399949.2_Silent_p.V166V|SPATA13_ENST00000382095.4_Silent_p.V244V|SPATA13_ENST00000409126.1_Intron|SPATA13_ENST00000382108.3_Silent_p.V869V			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	244					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GGACCAACGTCATCCGGGAGA	0.602000													29	68					0	0	1	0	0
CCP110	9738	broad.mit.edu	37	16	19547602	19547602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19547602C>T	ENST00000396212.2	+	5	1047	c.611C>T	c.(610-612)cCc>cTc	p.P204L	CCP110_ENST00000381396.5_Missense_Mutation_p.P204L|CCP110_ENST00000396208.2_Missense_Mutation_p.P204L	NM_014711.4	NP_055526.3	O43303	CP110_HUMAN	centriolar coiled coil protein 110kDa	204	CEP97 binding.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|stomach(3)|urinary_tract(1)	21						TCTGATGGTCCCTTCTCAGTA	0.393000													57	107					0	0	1	0	0
MIR299	407023	broad.mit.edu	37	14	101490176	101490176	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101490176G>A	ENST00000385016.2	+	0	63					NR_029841.1																						ATGTATGTGGGATGGTAAACC	0.532000													22	64					0	0	1	0	0
GLUD1	2746	broad.mit.edu	37	10	88818945	88818945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88818945G>A	ENST00000277865.4	-	10	1460	c.1364C>T	c.(1363-1365)aCc>aTc	p.T455I	GLUD1_ENST00000544149.1_Missense_Mutation_p.T322I|GLUD1_ENST00000537649.1_Missense_Mutation_p.T288I	NM_005271.3	NP_005262.1	P00367	DHE3_HUMAN	glutamate dehydrogenase 1	455					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(11)|prostate(1)	22					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATATTTGAAGGTCAAACGGCC	0.398000													66	183					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44676255	44676255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44676255C>T	ENST00000588883.1	+	4	338	c.30C>T	c.(28-30)ttC>ttT	p.F10F	ZNF226_ENST00000590089.1_Silent_p.F10F|ZNF226_ENST00000454662.2_Silent_p.F10F|ZNF226_ENST00000300823.6_Silent_p.F10F|ZNF226_ENST00000589160.1_Silent_p.F10F|ZNF226_ENST00000588742.1_Silent_p.F10F|ZNF226_ENST00000588795.1_Silent_p.F10F|ZNF226_ENST00000413984.2_Silent_p.F10F|ZNF226_ENST00000337433.5_Silent_p.F10F			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				CAGTGACCTTCAAGGACGTGG	0.507000													42	141					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7833869	7833869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7833869G>A	ENST00000327325.5	+	7	1313	c.1195G>A	c.(1195-1197)Gaa>Aaa	p.E399K	CLEC4M_ENST00000334806.5_Missense_Mutation_p.E348K|CLEC4M_ENST00000359059.5_Missense_Mutation_p.E332K|CLEC4M_ENST00000597522.1_3'UTR|CLEC4M_ENST00000596707.1_Missense_Mutation_p.E332K|CLEC4M_ENST00000248228.4_Missense_Mutation_p.E377K|CLEC4M_ENST00000596363.1_3'UTR|CLEC4M_ENST00000394122.2_Missense_Mutation_p.E387K|CLEC4M_ENST00000595496.1_Missense_Mutation_p.E263K|CLEC4M_ENST00000357361.2_3'UTR	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	399					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						CTTCAGAGACGAATAGTTGTT	0.498000													17	64					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76797772	76797772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76797772C>T	ENST00000286719.7	-	11	1344	c.988G>A	c.(988-990)Gag>Aag	p.E330K		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	330	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTTCTCTTCTCCTCCATCTGC	0.517000													18	64					0	0	1	0	0
ARHGEF38	54848	broad.mit.edu	37	4	106534592	106534592	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:106534592C>T	ENST00000420470.2	+	3	580	c.436C>T	c.(436-438)Cag>Tag	p.Q146*	ARHGEF38_ENST00000265154.2_Nonsense_Mutation_p.Q146*	NM_001242729.1	NP_001229658.1	Q9NXL2	ARH38_HUMAN	Rho guanine nucleotide exchange factor (GEF) 38	146	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(3)	11						GTCCGTGCATCAGATATCAGC	0.438000													12	157					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43652765	43652765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:43652765G>A	ENST00000378069.4	-	8	976	c.829C>T	c.(829-831)Cct>Tct	p.P277S	MAOB_ENST00000536181.1_Missense_Mutation_p.P261S|MAOB_ENST00000538942.1_Missense_Mutation_p.P261S	NM_000898.4	NP_000889.3	P27338	AOFB_HUMAN	monoamine oxidase B	277					xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(2)|skin(5)	21					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	ATTGGCAGAGGGGGATTGAAG	0.413000													48	34					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331570	85331570	+	Silent	SNP	G	G	A	rs142600008		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85331570G>A	ENST00000440886.1	-	1	272	c.234C>T	c.(232-234)ttC>ttT	p.F78F	LPAR3_ENST00000370611.3_Silent_p.F78F|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	78					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						CAATTCCAGCGAAGAAATCGG	0.433000													23	180					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21227996	21227996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21227996G>A	ENST00000233242.1	-	26	11871	c.11744C>T	c.(11743-11745)tCc>tTc	p.S3915F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3915					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCTGCATGTGGAATCCAGGAC	0.418000													56	122					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55269448	55269448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55269448C>T	ENST00000275493.2	+	26	3312	c.3135C>T	c.(3133-3135)tcC>tcT	p.S1045S	EGFR_ENST00000454757.2_Silent_p.S992S|EGFR_ENST00000455089.1_Silent_p.S1000S|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	1045	Ser-rich.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GCAACAATTCCACCGTGGCTT	0.433000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			45	117					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24125674	24125674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24125674C>T	ENST00000598975.1	-	1	471	c.472G>A	c.(472-474)Ggg>Agg	p.G158R	MMP11_ENST00000215743.3_Silent_p.P470P																							AAGGCTTCCCCCGTCTCGTGG	0.607000													31	76					0	0	1	0	0
NR2F1	7025	broad.mit.edu	37	5	92923983	92923983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:92923983C>T	ENST00000327111.3	+	2	2511	c.824C>T	c.(823-825)cCg>cTg	p.P275L		NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	275					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CACGTGGCGCCGTTGCTGGCC	0.662000													23	59					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86370031	86370031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:86370031C>T	ENST00000400286.2	-	2	1211	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	205						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CCAATGTGTTCGAGAAAACCA	0.403000													24	120					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40698283	40698283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40698283C>T	ENST00000253055.3	+	1	633	c.345C>T	c.(343-345)gcC>gcT	p.A115A	MAP3K10_ENST00000593906.1_3'UTR	NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	115	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						TCTATCGGGCCCTGTGGCGTG	0.682000													4	21					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333310	70333310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70333310G>A	ENST00000338508.4	-	32	3090	c.3091C>T	c.(3091-3093)Cct>Tct	p.P1031S	SHANK2_ENST00000423696.2_Missense_Mutation_p.P651S|SHANK2_ENST00000409161.1_Missense_Mutation_p.P434S|SHANK2_ENST00000449833.2_Missense_Mutation_p.P435S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	651					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GTCGGGATAGGGATGGAGCAC	0.662000													51	125					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104897581	104897581	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:104897581T>G	ENST00000533400.1	-	8	1139	c.1104A>C	c.(1102-1104)gaA>gaC	p.E368D	CASP1_ENST00000525825.1_Missense_Mutation_p.E347D|CASP1_ENST00000446369.1_Missense_Mutation_p.E227D|CASP1_ENST00000436863.3_Missense_Mutation_p.E368D|CASP1_ENST00000415981.2_Missense_Mutation_p.E52D|CASP1_ENST00000353247.5_Missense_Mutation_p.E52D|CASP1_ENST00000531166.1_Missense_Mutation_p.E52D|CASP1_ENST00000598974.1_Missense_Mutation_p.E368D|CASP1_ENST00000594519.1_Missense_Mutation_p.E227D|CASP1_ENST00000534497.1_Missense_Mutation_p.E227D|CASP1_ENST00000593315.1_Missense_Mutation_p.E347D|CASP1_ENST00000393136.4_Missense_Mutation_p.E347D|CASP1_ENST00000528974.1_3'UTR|CASP1_ENST00000527979.1_Missense_Mutation_p.E331D|CASP1_ENST00000526568.1_Missense_Mutation_p.E275D	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	368					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TGCGGAAAATTTCCTCCACAT	0.408000													26	72					0	0	1	0	0
PXK	54899	broad.mit.edu	37	3	58368345	58368345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58368345G>A	ENST00000463280.1	+	2	298	c.207G>A	c.(205-207)gtG>gtA	p.V69V	PXK_ENST00000536660.1_Intron|PXK_ENST00000479241.1_Silent_p.V85V|PXK_ENST00000484288.1_Silent_p.V102V|PXK_ENST00000383716.3_Silent_p.V69V|PXK_ENST00000383715.4_Silent_p.V85V|PXK_ENST00000356151.2_Silent_p.V102V|PXK_ENST00000302779.5_Silent_p.V85V			Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	102	PX.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		ATCTCAACGTGATCACAACAA	0.388000													25	56					0	0	1	0	0
CHAF1B	8208	broad.mit.edu	37	21	37788600	37788600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37788600C>T	ENST00000314103.4	+	14	1767	c.1616C>T	c.(1615-1617)cCc>cTc	p.P539L		NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)	539					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						CAGGGCAGTCCCCCAGAGCTA	0.517000													10	30					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111397710	111397710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111397710G>A	ENST00000265162.5	+	1	482	c.140G>A	c.(139-141)gGg>gAg	p.G47E		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	47					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GACTCCAGCGGGGACGGCGGG	0.632000													46	131					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26872494	26872494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26872494C>T	ENST00000531382.1	+	1	152	c.103C>T	c.(103-105)Cct>Tct	p.P35S	RPS6KA1_ENST00000530003.1_Intron|RPS6KA1_ENST00000526792.1_Intron|RPS6KA1_ENST00000374162.2_Intron|RPS6KA1_ENST00000374166.4_Intron|RPS6KA1_ENST00000374168.2_Intron	NM_001006665.1	NP_001006666.1	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	26					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TCTGCCTGTCCCTGGCCCTGG	0.687000													3	25					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30891358	30891358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30891358G>A	ENST00000392772.2	-	5	421	c.144C>T	c.(142-144)atC>atT	p.I48I	SEC14L4_ENST00000381982.3_Silent_p.I102I|SEC14L4_ENST00000255858.7_Silent_p.I102I|SEC14L4_ENST00000540456.1_Silent_p.I87I			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	102						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	GGGACCCAATGATGTTGAAGT	0.547000													25	67					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73677031	73677031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73677031C>T	ENST00000264448.6	+	8	3485	c.3374C>T	c.(3373-3375)gCt>gTt	p.A1125V	ALMS1_ENST00000409009.1_Missense_Mutation_p.A1083V|ALMS1_ENST00000377715.1_Missense_Mutation_p.A1125V	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1125	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ATTTCAGTAGCTCCTGGACTA	0.473000													50	227					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137593095	137593095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137593095C>T	ENST00000371817.3	+	4	984	c.570C>T	c.(568-570)ttC>ttT	p.F190F	COL5A1_ENST00000464187.1_3'UTR	NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	190	Laminin G-like.|TSP N-terminal.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCACCAAATTCCTCGACCGCA	0.512000													7	28					0	0	1	0	0
PA2G4	5036	broad.mit.edu	37	12	56504236	56504236	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56504236T>C	ENST00000303305.6	+	8	1102	c.683T>C	c.(682-684)gTt>gCt	p.V228A	RP11-603J24.17_ENST00000548595.1_RNA|PA2G4_ENST00000552766.1_Missense_Mutation_p.V228A	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	228					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			GCTGTGGATGTTCTCGTCAGC	0.408000													38	66					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28966722	28966722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28966722C>T	ENST00000359747.4	+	3	185	c.156C>T	c.(154-156)atC>atT	p.I52I	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Silent_p.I52I|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	52	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGGAGTGGATCAAGTTTGCCG	0.438000													9	110					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103149037	103149037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103149037G>A	ENST00000295269.4	+	12	2744	c.2287G>A	c.(2287-2289)Gag>Aag	p.E763K		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	763					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GTCTGGAGGGGAGAGTGAGGG	0.552000													11	31					0	0	1	0	0
WISP2	8839	broad.mit.edu	37	20	43355771	43355771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43355771C>T	ENST00000372865.4	+	3	837	c.329C>T	c.(328-330)tCc>tTc	p.S110F	WISP2_ENST00000372868.2_Silent_p.V192V|RP11-445H22.4_ENST00000445420.1_RNA|WISP2_ENST00000471629.1_3'UTR|RP11-445H22.4_ENST00000427598.1_RNA|WISP2_ENST00000190983.4_Silent_p.V192V|RP11-445H22.4_ENST00000427303.1_RNA			O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	99	VWFC.				cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CCCCTGGTGTCCCCTGCCCAG	0.632000													57	107					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125805234	125805234	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:125805234G>A	ENST00000346248.5	-	2	1137	c.495C>T	c.(493-495)ttC>ttT	p.F165F	CHST15_ENST00000421115.1_Silent_p.F165F|CHST15_ENST00000435907.1_Silent_p.F165F	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	165					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						GTCTGGTCGTGAACTCAATCC	0.383000													109	284					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29121164	29121164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29121164C>T	ENST00000261590.8	+	13	2097	c.1888C>T	c.(1888-1890)Ctt>Ttt	p.L630F		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	630					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGTGGTACCACTTTTACTGCT	0.423000													25	74					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45303824	45303824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:45303824C>T	ENST00000303230.4	-	6	1552	c.1495G>A	c.(1495-1497)Gga>Aga	p.G499R		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	499						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.G499L(1)|p.G499R(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ATATAATCTCCAGGTTGAAAC	0.408000													33	135					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933065	43933065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43933065C>T	ENST00000537548.1	-	4	690	c.446G>A	c.(445-447)cGg>cAg	p.R149Q	MATN4_ENST00000372751.4_Intron|MATN4_ENST00000353917.5_Missense_Mutation_p.R149Q|MATN4_ENST00000342716.4_Missense_Mutation_p.R149Q|MATN4_ENST00000372756.1_Missense_Mutation_p.R149Q|MATN4_ENST00000360607.5_Missense_Mutation_p.R149Q|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000372754.1_Missense_Mutation_p.R149Q			O95460	MATN4_HUMAN	matrilin 4	149	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				GTCCTGGGGCCGCCCGTCTGT	0.721000													3	12					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103410325	103410325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103410325G>A	ENST00000361246.2	-	30	4599	c.4311C>T	c.(4309-4311)taC>taT	p.Y1437Y		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1437	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		AGCAAAGCAGGTACTCCTCGC	0.582000													27	50					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54579090	54579090	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:54579090C>T	ENST00000064571.2	-	1	1438	c.138G>A	c.(136-138)tcG>tcA	p.S46S		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	46						cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			TGGCCGGGTTCGAGTCGCACA	0.687000													10	46					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207643161	207643161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207643161G>A	ENST00000367057.3	+	6	1128	c.939G>A	c.(937-939)gtG>gtA	p.V313V	CR2_ENST00000367058.3_Silent_p.V313V|CR2_ENST00000485707.1_3'UTR|CR2_ENST00000458541.2_Silent_p.V313V|CR2_ENST00000367059.3_Silent_p.V313V	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	313	Sushi 5.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						AGGAAGGAGTGAACTTCATCC	0.483000													26	58					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810695	7810695	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7810695G>A	ENST00000315599.7	-	4	479	c.457C>T	c.(457-459)Ctg>Ttg	p.L153L	CD209_ENST00000601951.1_Silent_p.L129L|CD209_ENST00000301357.8_Intron|CD209_ENST00000315591.8_Silent_p.L129L|CD209_ENST00000204801.8_Silent_p.L109L|CD209_ENST00000602261.1_Silent_p.L153L|CD209_ENST00000601256.1_Silent_p.L129L|CD209_ENST00000394161.5_Intron|CD209_ENST00000593660.1_Silent_p.L129L|CD209_ENST00000354397.6_Silent_p.L153L|CD209_ENST00000593821.1_Silent_p.L109L|CD209_ENST00000394173.4_Intron	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	153	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCAGCCTTCAGCCAGGTCAGC	0.562000													76	178					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160109728	160109728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160109728C>T	ENST00000361216.3	+	22	3077	c.2988C>T	c.(2986-2988)ttC>ttT	p.F996F	ATP1A2_ENST00000392233.3_Silent_p.F985F	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	996					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TCCTCATCTTCATCTATGATG	0.577000													33	124					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32037544	32037544	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32037544G>A	ENST00000375244.3	-	15	5574	c.5373C>T	c.(5371-5373)tcC>tcT	p.S1791S	TNXB_ENST00000375247.2_Silent_p.S1791S			P22105	TENX_HUMAN	tenascin XB	1873	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AGAGGCCCACGGAGTTCTGGG	0.617000													6	24					0	0	1	0	0
PHKB	5257	broad.mit.edu	37	16	47628107	47628107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:47628107C>T	ENST00000455779.1	+	13	1350	c.1165C>T	c.(1165-1167)Ctt>Ttt	p.L389F	PHKB_ENST00000323584.5_Missense_Mutation_p.L396F|PHKB_ENST00000299167.8_Missense_Mutation_p.L396F|PHKB_ENST00000566044.1_Missense_Mutation_p.L389F			Q93100	KPBB_HUMAN	phosphorylase kinase, beta	396					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GACTCCAGTACTTCATCATAC	0.313000													7	66					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10551334	10551334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10551334G>A	ENST00000396560.2	+	7	1527	c.1300G>A	c.(1300-1302)Gga>Aga	p.G434R	ATF7IP2_ENST00000396559.1_Missense_Mutation_p.G434R|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000356427.2_Missense_Mutation_p.G434R|ATF7IP2_ENST00000324570.5_Missense_Mutation_p.G434R	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						TTCCGAAAAAGGAAGTAAAAA	0.294000													43	110					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402853	124402853	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124402853A>G	ENST00000338354.3	+	53	7287	c.7181A>G	c.(7180-7182)gAc>gGc	p.D2394G	DMBT1_ENST00000344338.3_Missense_Mutation_p.D2384G|DMBT1_ENST00000368955.3_Missense_Mutation_p.D2384G|DMBT1_ENST00000359586.6_Missense_Mutation_p.D1114G|DMBT1_ENST00000330163.4_Missense_Mutation_p.D1766G|DMBT1_ENST00000368956.2_Missense_Mutation_p.D1766G|DMBT1_ENST00000368909.3_Missense_Mutation_p.D2394G			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2394					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GAAAAGGTGGACGTCGTCCTG	0.627000													21	42					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16360108	16360108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16360108G>A	ENST00000375692.1	+	21	2144	c.2016G>A	c.(2014-2016)atG>atA	p.M672I	CLCNKA_ENST00000331433.4_Missense_Mutation_p.M673I|CLCNKA_ENST00000439316.2_Missense_Mutation_p.M630I|CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000420078.1_Missense_Mutation_p.M672I			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	673	CBS 2.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	TGTTCTAGATGAAGAAAGCAA	0.552000													15	55					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113237474	113237474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113237474C>T	ENST00000369644.1	+	11	2437	c.1408C>T	c.(1408-1410)Cca>Tca	p.P470S	MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000413052.2_Missense_Mutation_p.P526S|RP11-426L16.3_ENST00000421943.1_RNA|MOV10_ENST00000369645.1_Missense_Mutation_p.P526S|MOV10_ENST00000357443.2_Missense_Mutation_p.P526S			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	526					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CTTTGGGCCTCCAGGCACCGG	0.597000													5	65					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14022150	14022150	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:14022150C>T	ENST00000382080.1	-	5	1201	c.486G>A	c.(484-486)agG>agA	p.R162R	RP11-3G21.1_ENST00000527110.1_RNA|SGCZ_ENST00000421524.2_Silent_p.R115R	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	149					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		AAAACAGCACCCTGCCATCTT	0.413000													27	57					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179475048	179475048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179475048C>T	ENST00000589042.1	-	271	51429	c.51205G>A	c.(51205-51207)Gaa>Aaa	p.E17069K	TTN_ENST00000342992.6_Missense_Mutation_p.E14501K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E15428K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E8196K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E8129K|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E8004K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15428	Ig-like 102.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGGAGGTTCCCAAGTTAAC	0.398000													53	114					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55223540	55223540	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55223540G>A	ENST00000275493.2	+	8	1084	c.907G>A	c.(907-909)Gat>Aat	p.D303N	EGFR_ENST00000420316.2_Missense_Mutation_p.D303N|EGFR_ENST00000454757.2_Missense_Mutation_p.D250N|EGFR_ENST00000455089.1_Missense_Mutation_p.D258N|EGFR_ENST00000442591.1_Missense_Mutation_p.D303N|EGFR_ENST00000344576.2_Missense_Mutation_p.D303N|EGFR_ENST00000342916.3_Missense_Mutation_p.D303N	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	303					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.D303H(2)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGTGGTGACAGATCACGGCTC	0.597000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			16	81					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121944331	121944331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121944331C>T	ENST00000442488.2	-	1	228	c.161G>A	c.(160-162)gGa>gAa	p.G54E	FEZF1-AS1_ENST00000428449.1_RNA|FEZF1_ENST00000331178.4_Missense_Mutation_p.G54E|FEZF1_ENST00000427185.2_Missense_Mutation_p.G54E	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	54					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						GGGTAAGGCTCCCTGCAGGAA	0.597000													45	117					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47282381	47282381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47282381C>T	ENST00000335044.2	-	17	2191	c.1834G>A	c.(1834-1836)Gag>Aag	p.E612K	KIF9-AS1_ENST00000429315.3_RNA|KIF9_ENST00000444589.2_Missense_Mutation_p.E547K|KIF9_ENST00000265529.3_Missense_Mutation_p.E612K|KIF9_ENST00000352910.4_Missense_Mutation_p.E454K|KIF9_ENST00000452770.2_Missense_Mutation_p.E612K|KIF9_ENST00000487440.1_5'UTR	NM_001134878.1|NM_182902.3	NP_001128350.1|NP_878905.2	Q9HAQ2	KIF9_HUMAN	kinesin family member 9	612					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TGTGTGGTCTCGCTGGCCCTT	0.458000													41	90					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31914822	31914822	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31914822G>A	ENST00000456570.1	+	15	1898	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K	CFB_ENST00000425368.2_Missense_Mutation_p.E113K|CFB_ENST00000477310.1_Missense_Mutation_p.E464K|CFB_ENST00000556679.1_Missense_Mutation_p.E615K			P00751	CFAB_HUMAN	complement factor B	113	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CGAGAACGGGGAATACTGGCC	0.532000													29	61					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926255	1926255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1926255C>T	ENST00000399161.2	-	10	2033	c.1286G>A	c.(1285-1287)gGg>gAg	p.G429E	MYT1L_ENST00000428368.2_Missense_Mutation_p.G429E	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	429					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGTCAGGTTCCCCTTGGTCAT	0.552000													35	91					0	0	1	0	0
SPAG1	6674	broad.mit.edu	37	8	101178079	101178079	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101178079T>A	ENST00000388798.2	+	3	369	c.178T>A	c.(178-180)Ttt>Att	p.F60I	SPAG1_ENST00000251809.3_Missense_Mutation_p.F60I|SPAG1_ENST00000520508.1_Missense_Mutation_p.F60I|SPAG1_ENST00000520643.1_Missense_Mutation_p.F60I	NM_003114.4	NP_003105.2	Q07617	SPAG1_HUMAN	sperm associated antigen 1	60					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		ACTTACAGAATTTTGTGAAAA	0.398000													20	69					0	0	1	0	0
RPS6KB2	6199	broad.mit.edu	37	11	67201482	67201482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67201482C>T	ENST00000312629.5	+	11	968	c.923C>T	c.(922-924)cCc>cTc	p.P308L	AP003419.16_ENST00000535922.1_RNA	NM_003952.2	NP_003943.2	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 2	308	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|salivary_gland(1)|stomach(2)	25			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			AAACGGAATCCCAGCCAGCGG	0.642000													7	53					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616242	179616242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179616242C>T	ENST00000360870.5	-	46	11107	c.10885G>A	c.(10885-10887)Gat>Aat	p.D3629N	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9478	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTATCCTATCTTCTCCCCTT	0.368000													91	173					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31599462	31599462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31599462C>T	ENST00000376033.2	+	16	3246	c.3012C>T	c.(3010-3012)tcC>tcT	p.S1004S	PRRC2A_ENST00000376007.4_Silent_p.S1004S	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1004	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						GAAATCTTTCCCCTGCCCCAA	0.592000													10	18					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123754798	123754798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123754798G>A	ENST00000375026.2	-	3	663	c.447C>T	c.(445-447)ttC>ttT	p.F149F		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	149						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						CAGACAAGAAGAAAACATTTA	0.433000													16	91					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109690130	109690130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:109690130C>T	ENST00000277225.5	+	3	4226	c.3937C>T	c.(3937-3939)Cac>Tac	p.H1313Y	ZNF462_ENST00000457913.1_Missense_Mutation_p.H1313Y|ZNF462_ENST00000441147.2_Missense_Mutation_p.H158Y			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1313					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						AGCTGGCTACCACTGCGAGTG	0.517000													14	141					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113168633	113168633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113168633C>T	ENST00000401783.2	-	38	9583	c.9247G>A	c.(9247-9249)Gaa>Aaa	p.E3083K	SVEP1_ENST00000374469.1_Missense_Mutation_p.E3060K|SVEP1_ENST00000297826.5_Missense_Mutation_p.E1009K	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3083	Sushi 28.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ATCACATTTTCCTTCCAAGAG	0.473000													39	132					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189872637	189872637	+	Silent	SNP	C	C	T	rs148918486		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189872637C>T	ENST00000304636.3	+	46	3560	c.3390C>T	c.(3388-3390)atC>atT	p.I1130I	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1130	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AGGGTGCAATCGGCAGTCCAG	0.468000													32	85					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634323	32634323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32634323C>T	ENST00000242310.4	-	1	1344	c.1255G>A	c.(1255-1257)Gaa>Aaa	p.E419K	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	419					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGGAAGTTTTCGTCAGCCAGA	0.443000													65	246					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580483	140580483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580483G>A	ENST00000354757.3	+	1	1136	c.1136G>A	c.(1135-1137)gGa>gAa	p.G379E	PCDHB11_ENST00000536699.1_Missense_Mutation_p.G14E	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		379	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGGACAACGGAAGAATTGTT	0.433000													35	114					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138578	126138578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:126138578C>T	ENST00000299308.3	+	9	2567	c.2559C>T	c.(2557-2559)ccC>ccT	p.P853P	TMEM132B_ENST00000535886.1_Silent_p.P365P	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	853						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCCAGTCTCCCATGGAAGGGA	0.522000													12	54					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8609249	8609249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8609249C>T	ENST00000338257.8	-	14	1723	c.1456G>A	c.(1456-1458)Gct>Act	p.A486T		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	486	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GTCCCCACAGCCGCCTGCAGC	0.672000													13	28					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207108834	207108834	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207108834C>T	ENST00000356495.4	-	5	1558	c.1375G>A	c.(1375-1377)Gaa>Aaa	p.E459K		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	459						extracellular region|integral to plasma membrane	protein binding	p.E459K(1)		central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTCCTACCTTCGATAATCTTG	0.567000											OREG0014186	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	78					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115394878	115394878	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:115394878G>A	ENST00000393780.3	+	3	625	c.157G>A	c.(157-159)Gac>Aac	p.D53N	GAP43_ENST00000305124.6_Missense_Mutation_p.D17N	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	17	IQ.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		AAATGATGACGACCAAAAGAT	0.373000													37	68					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236208779	236208779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236208779C>T	ENST00000264187.6	-	3	812	c.730G>A	c.(730-732)Gaa>Aaa	p.E244K	NID1_ENST00000366595.3_Missense_Mutation_p.E244K	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	244	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TCAACTGATTCCCTGTCATTA	0.363000													26	60					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2110321	2110321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:2110321C>T	ENST00000382203.1	+	24	3569	c.3360C>T	c.(3358-3360)ttC>ttT	p.F1120F	SMARCA2_ENST00000382194.1_Silent_p.F1120F|SMARCA2_ENST00000349721.2_Silent_p.F1120F|SMARCA2_ENST00000357248.2_Silent_p.F1120F			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1120	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CCCAGTATTTCATTTTCTTGC	0.453000													26	57					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533756	92533756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92533756G>A	ENST00000298047.6	+	9	7594	c.7577G>A	c.(7576-7578)gGg>gAg	p.G2526E	FAT3_ENST00000525166.1_Missense_Mutation_p.G2376E|FAT3_ENST00000409404.2_Missense_Mutation_p.G2526E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2526	Cadherin 23.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGTGATCCAGGGACTTATGGG	0.493000										TCGA Ovarian(4;0.039)			4	19					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142458426	142458426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142458426G>A	ENST00000486171.1	+	2	78	c.61G>A	c.(61-63)Gat>Aat	p.D21N	PRSS1_ENST00000311737.7_Missense_Mutation_p.D21N			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	21					digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CTTTGATGATGATGACAAGAT	0.532000													53	257					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561151	9561151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9561151C>T	ENST00000378429.3	-	5	1177	c.631G>A	c.(631-633)Gaa>Aaa	p.E211K	PAK7_ENST00000378423.1_Missense_Mutation_p.E211K|PAK7_ENST00000353224.5_Missense_Mutation_p.E211K	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	211	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TCACTGTATTCACTTGGTTTG	0.483000													39	75					0	0	1	0	0
GGTLC2	91227	broad.mit.edu	37	22	22989341	22989341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22989341C>T	ENST00000448514.1	+	2	294	c.294C>T	c.(292-294)ttC>ttT	p.F98F	GGTLC2_ENST00000480559.1_Silent_p.F98F			Q14390	GGTL2_HUMAN	gamma-glutamyltransferase light chain 2	98					glutathione biosynthetic process		gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		CTGCCAATTTCATCCAGCCAG	0.612000													72	168					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17668547	17668547	+	Silent	SNP	C	C	T	rs138788718	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17668547C>T	ENST00000375448.4	+	7	788	c.762C>T	c.(760-762)ctC>ctT	p.L254L	AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	254					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	TGGAGGCCCTCGCTTTCCCGG	0.617000													21	54					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196965187	196965187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196965187G>A	ENST00000367414.5	+	6	954	c.898G>A	c.(898-900)Gag>Aag	p.E300K	CFHR5_ENST00000256785.4_Missense_Mutation_p.E276K	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	276	Sushi 5.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						ACCTGAACTCGAGTACGGTTA	0.348000													37	114					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2129298	2129298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2129298C>T	ENST00000219476.3	+	28	3783	c.3153C>T	c.(3151-3153)ctC>ctT	p.L1051L	TSC2_ENST00000382538.6_Silent_p.L959L|TSC2_ENST00000568366.1_3'UTR|TSC2_ENST00000568454.1_Silent_p.L1018L|TSC2_ENST00000350773.4_Silent_p.L1051L|TSC2_ENST00000439673.2_Silent_p.L971L|TSC2_ENST00000353929.4_Silent_p.L1008L|TSC2_ENST00000401874.2_Silent_p.L1007L	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1051					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				GCGAGTTCCTCCTAGCGGGTG	0.637000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				28	45					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50147111	50147111	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50147111G>A	ENST00000376025.2	-	0	1073							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TGCAGTGCTGGGTCCGGTGGC	0.433000													21	13					0	0	1	0	0
FAM46D	169966	broad.mit.edu	37	X	79698625	79698625	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:79698625A>T	ENST00000538312.1	+	5	921	c.587A>T	c.(586-588)aAa>aTa	p.K196I	FAM46D_ENST00000308293.5_Missense_Mutation_p.K196I	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	196										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						AAGCTAACCAAAGAATCCTAT	0.403000													38	18					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72862917	72862917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72862917G>A	ENST00000455107.2	-	4	543	c.127C>T	c.(127-129)Ccc>Tcc	p.P43S	FDXR_ENST00000581530.1_Missense_Mutation_p.P87S|FDXR_ENST00000413947.2_Missense_Mutation_p.P118S|FDXR_ENST00000293195.5_Missense_Mutation_p.P87S|FDXR_ENST00000544854.1_Missense_Mutation_p.P35S|FDXR_ENST00000581969.1_5'UTR|FDXR_ENST00000420580.2_Missense_Mutation_p.P88S|FDXR_ENST00000442102.2_Missense_Mutation_p.P130S|FDXR_ENST00000582944.1_Missense_Mutation_p.P87S|FDXR_ENST00000583917.1_Missense_Mutation_p.P88S			P22570	ADRO_HUMAN	ferredoxin reductase	87					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					TTCACCTCGGGGTGATCAGGC	0.632000													14	33					0	0	1	0	0
UCP1	7350	broad.mit.edu	37	4	141484541	141484541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141484541G>A	ENST00000262999.3	-	3	532	c.457C>T	c.(457-459)Cgc>Tgc	p.R153C		NM_021833.4	NP_068605.1	P25874	UCP1_HUMAN	uncoupling protein 1 (mitochondrial, proton carrier)	153					brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|stomach(1)	16	all_hematologic(180;0.162)					CCCGTGTAGCGAGGTTTGATT	0.463000													47	86					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141902	133141902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133141902C>T	ENST00000388996.4	-	15	2646	c.2226G>A	c.(2224-2226)gtG>gtA	p.V742V	KCNQ3_ENST00000519445.1_Silent_p.V730V|KCNQ3_ENST00000521134.1_Silent_p.V622V	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	742					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGGGCCTCTCCACATACGTTG	0.592000													17	27					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178442297	178442297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:178442297C>T	ENST00000448150.3	+	18	4551	c.3733C>T	c.(3733-3735)Cgc>Tgc	p.R1245C	RASAL2_ENST00000367649.3_Missense_Mutation_p.R1256C|RASAL2_ENST00000462775.1_Missense_Mutation_p.R1115C	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	1115					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						CATGCAGGTCCGCAATGGCAT	0.542000													26	78					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6174838	6174838	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6174838G>A	ENST00000264870.3	-	12	1987	c.1722C>T	c.(1720-1722)ttC>ttT	p.F574F		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	574					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GCGTCACGTCGAACGTCTCCT	0.522000													57	147					0	0	1	0	0
OR6C1	390321	broad.mit.edu	37	12	55714563	55714563	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55714563C>T	ENST00000379668.2	+	1	218	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_001005182.1	NP_001005182.1	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C, member 1	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|liver(2)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	25						TGTATTTCTTCCTCAGAAATT	0.418000													33	80					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43821218	43821218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43821218C>T	ENST00000389420.3	-	27	3999	c.4000G>A	c.(4000-4002)Gaa>Aaa	p.E1334K	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.E452K|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E1334K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1334	TSP type-1 9.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TGTCCATTTTCATCCTGGCAG	0.488000													18	40					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699504	52699504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52699504G>A	ENST00000293525.5	+	6	1010	c.958G>A	c.(958-960)Gag>Aag	p.E320K	KRT86_ENST00000544024.1_Missense_Mutation_p.E320K|KRT86_ENST00000423955.2_Missense_Mutation_p.E320K	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	320	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCGCACCAAGGAGGAGATCAA	0.597000													8	87					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46835200	46835200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46835200G>A	ENST00000262738.3	-	3	4291	c.4292C>T	c.(4291-4293)cCt>cTt	p.P1431L		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1431	EGF-like 3; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CTCGCCAGGAGGACACACGCA	0.647000													7	68					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75113409	75113409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75113409G>A	ENST00000310715.3	-	3	275	c.155C>T	c.(154-156)cCa>cTa	p.P52L	TTC18_ENST00000394865.1_Missense_Mutation_p.P52L|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000340329.3_Missense_Mutation_p.P52L|TTC18_ENST00000401621.2_Missense_Mutation_p.P52L	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	52							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					ACTTCCTTCTGGAGAAACAGT	0.403000													19	84					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241808421	241808421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241808421G>A	ENST00000307503.3	+	1	526	c.139G>A	c.(139-141)Ggg>Agg	p.G47R		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	47					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GCAGATGATCGGGTCCATGAG	0.642000													36	73					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168101389	168101389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168101389C>T	ENST00000409195.1	+	9	3576	c.3487C>T	c.(3487-3489)Cgt>Tgt	p.R1163C	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R1163C|XIRP2_ENST00000409273.1_Missense_Mutation_p.R941C|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	988					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGGGGATGTTCGTACAGCATG	0.403000													17	81					0	0	1	0	0
SET	6418	broad.mit.edu	37	9	131455961	131455961	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131455961G>A	ENST00000322030.8	+	6	894	c.537G>A	c.(535-537)agG>agA	p.R179R	SET_ENST00000477806.1_3'UTR|SET_ENST00000372688.4_Silent_p.R168R|SET_ENST00000409104.3_Silent_p.R170R|SET_ENST00000372692.4_Silent_p.R192R	NM_003011.3	NP_003002.2	Q01105	SET_HUMAN	SET nuclear oncogene	192					DNA replication|mRNA metabolic process|negative regulation of histone acetylation|negative regulation of neuron apoptosis|negative regulation of transcription, DNA-dependent|nucleocytoplasmic transport|nucleosome assembly|nucleosome disassembly	cytosol|endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm|protein complex	histone binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity			endometrium(2)|kidney(1)|lung(2)	5		Myeloproliferative disorder(178;0.204)		GBM - Glioblastoma multiforme(294;3.1e-09)		AAGCCAGCAGGAAGAGGCAGC	0.438000			T	NUP214	AML								7	70					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19070876	19070876	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19070876G>A	ENST00000569532.1	+	15	2296	c.2166G>A	c.(2164-2166)agG>agA	p.R722R	TMC7_ENST00000421369.3_Intron|TMC7_ENST00000304381.5_Intron			Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	111						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						ACACTGCAAGGAAAGTGCTGT	0.557000													9	28					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72846421	72846421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72846421G>A	ENST00000293190.5	-	6	1561	c.1415C>T	c.(1414-1416)tCc>tTc	p.S472F	GRIN2C_ENST00000347612.4_Missense_Mutation_p.S472F	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	472					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CAGGTCGTAGGAGAATTTGAC	0.607000													49	118					0	0	1	0	0
SMPD4P1	645280	broad.mit.edu	37	22	20977088	20977088	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20977088C>T	ENST00000443839.1	-	0	1446																											ACAAGGACACCATCCAGGCTG	0.582000													7	9					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82816544	82816544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82816544G>A	ENST00000265077.3	+	7	2984	c.2419G>A	c.(2419-2421)Gaa>Aaa	p.E807K	VCAN_ENST00000512590.2_Missense_Mutation_p.E759K|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.E807K	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	807	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding	p.E807K(1)		NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GTCATGGGATGAAGATAATAC	0.413000													15	97					0	0	1	0	0
IL23A	51561	broad.mit.edu	37	12	56733246	56733246	+	Missense_Mutation	SNP	G	G	A	rs150940553		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56733246G>A	ENST00000228534.4	+	2	365	c.199G>A	c.(199-201)Gat>Aat	p.D67N		NM_016584.2	NP_057668.1	Q9NPF7	IL23A_HUMAN	interleukin 23, alpha subunit p19	67					defense response to Gram-negative bacterium|inflammatory response|innate immune response|negative regulation of interleukin-10 production|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to virus|tissue remodeling	interleukin-23 complex	cytokine activity			kidney(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	5						GACTACAAATGATGTTCCCCA	0.493000													15	58					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033245	82033245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82033245C>T	ENST00000328945.5	-	3	780	c.653G>A	c.(652-654)aGc>aAc	p.S218N		NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	218					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CTCAACCAGGCTCCTGGGGTC	0.557000													51	141					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151108512	151108512	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151108512G>A	ENST00000341697.3	-	13	2925	c.1234C>T	c.(1234-1236)Cag>Tag	p.Q412*				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	412	Sema.					integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGTAGAGGCTGATGGGTGACA	0.557000													31	54					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178557010	178557010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178557010C>T	ENST00000251582.7	-	16	2481	c.2380G>A	c.(2380-2382)Gag>Aag	p.E794K		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	794	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TACTCCCACTCCACGCCCATG	0.582000													20	62					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150715528	150715528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150715528G>A	ENST00000605938.1	-	7	1800	c.1725C>T	c.(1723-1725)ttC>ttT	p.F575F	ATG9B_ENST00000377974.2_Silent_p.F575F|ATG9B_ENST00000444312.1_Silent_p.F61F|ATG9B_ENST00000494791.1_5'UTR	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	575					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTCCGGAATGAAAGACCTGA	0.677000											OREG0018444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	48					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43569108	43569108	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43569108G>C	ENST00000452443.2	-	12	1929	c.1925C>G	c.(1924-1926)aCg>aGg	p.T642R		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	642					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CAGCACCATCGTGCAGCTGCT	0.582000													21	42					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120150415	120150415	+	Silent	SNP	G	G	A	rs147828404		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120150415G>A	ENST00000392521.2	-	36	4720	c.4665C>T	c.(4663-4665)ctC>ctT	p.L1555L	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Silent_p.L1513L	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1513	PH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTGTATTTGCGAGTTCGGAAG	0.607000													13	73					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56822682	56822682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56822682G>A	ENST00000229201.4	-	11	1440	c.1286C>T	c.(1285-1287)gCc>gTc	p.A429V	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Missense_Mutation_p.A430V	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	430			A -> D (in a breast cancer sample; somatic mutation).		cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TGCCCAGGAGGCAGCTTCCTT	0.522000													29	44					0	0	1	0	0
ZBTB33	10009	broad.mit.edu	37	X	119388433	119388433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:119388433C>T	ENST00000326624.2	+	2	1391	c.1163C>T	c.(1162-1164)tCc>tTc	p.S388F	ZBTB33_ENST00000557385.1_Missense_Mutation_p.S388F	NM_006777.3	NP_006768.1	Q86T24	KAISO_HUMAN	zinc finger and BTB domain containing 33	388					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	26						CTTTCCAATTCCTTAAAAATT	0.363000													47	42					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513660	99513660	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:99513660G>A	ENST00000261037.3	+	5	1295	c.915G>A	c.(913-915)ggG>ggA	p.G305G	COL8A1_ENST00000273342.4_Silent_p.G305G	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	305	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGGTACCGGGGGTTCAAGGAC	0.642000													16	30					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67399174	67399174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67399174G>A	ENST00000335385.3	-	8	1147	c.1060C>T	c.(1060-1062)Cgg>Tgg	p.R354W		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	354					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						CTATCAGCCCGGATGTTGGGG	0.652000													3	17					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20492235	20492235	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20492235C>T	ENST00000573854.1	+	12	1615	c.1501C>T	c.(1501-1503)Cga>Tga	p.R501*	ACSM2A_ENST00000417235.2_Nonsense_Mutation_p.R422*|ACSM2A_ENST00000536134.1_Nonsense_Mutation_p.R273*|ACSM2A_ENST00000396104.2_Nonsense_Mutation_p.R501*|ACSM2A_ENST00000219054.6_Nonsense_Mutation_p.R501*|ACSM2A_ENST00000575690.1_Nonsense_Mutation_p.R501*|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	501					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AGACCCCGTCCGAGGAGAGGT	0.562000													13	39					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214772	161214772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161214772C>T	ENST00000327928.4	+	1	177	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	59						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AAACCCTCTTCACAGAAATGG	0.468000													30	72					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8196452	8196452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8196452G>A	ENST00000600128.1	-	15	2390	c.1976C>T	c.(1975-1977)cCt>cTt	p.P659L	FBN3_ENST00000601739.1_Missense_Mutation_p.P659L|FBN3_ENST00000270509.2_Missense_Mutation_p.P659L			Q75N90	FBN3_HUMAN	fibrillin 3	659	TB 3.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTCTTTGGCAGGACAAAGCTG	0.642000													12	102					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113346348	113346348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113346348C>T	ENST00000452357.2	+	2	378	c.188C>T	c.(187-189)tCc>tTc	p.S63F	OAS1_ENST00000553185.1_Missense_Mutation_p.S63F|OAS1_ENST00000445409.2_Missense_Mutation_p.S63F|OAS1_ENST00000202917.5_Missense_Mutation_p.S63F|OAS1_ENST00000551241.1_Missense_Mutation_p.S63F|RP1-71H24.1_ENST00000552784.1_RNA	NM_002534.2	NP_002525.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	63					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						CAGGGTGGCTCCTCAGGCAAG	0.478000													20	42					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25610343	25610343	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25610343C>T	ENST00000329474.6	+	36	4281	c.3913C>T	c.(3913-3915)Cct>Tct	p.P1305S		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1305					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						GAAAAAAGTTCCTTCAGACAA	0.473000													46	116					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43214429	43214429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43214429G>A	ENST00000259750.4	+	2	114	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	11						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCTTAAGGACGAAACCAACAT	0.667000													12	40					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140219477	140219477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:140219477G>A	ENST00000275884.6	-	18	3370	c.2953C>T	c.(2953-2955)Ccc>Tcc	p.P985S	DENND2A_ENST00000496613.1_Missense_Mutation_p.P985S|DENND2A_ENST00000537639.1_Missense_Mutation_p.P985S			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	985										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					TCTCCACTGGGGAGTGTTTCC	0.527000													10	144					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37670762	37670762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37670762G>A	ENST00000264741.5	+	16	2030	c.1774G>A	c.(1774-1776)Gaa>Aaa	p.E592K	ITGA9_ENST00000422441.1_Missense_Mutation_p.E592K	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	592					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GGAGGAGAGGGAACTGCCGCC	0.517000													11	31					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37187885	37187885	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37187885G>A	ENST00000425901.2	+	0	1727					NR_033753.2																						TTTGGATCTGGAACTTACCTT	0.488000													29	44					0	0	1	0	0
RNA5-8SP2	100873571	broad.mit.edu	37	16	33965525	33965525	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:33965525C>T	ENST00000363564.1	+	0	100																											ATCGACACTTCGAACGCAATT	0.572000													9	33					0	0	1	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266304	3266304	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3266304G>A	ENST00000576468.1	+	0	418																											ATCCACAAAGGGAAGATGGAA	0.522000													15	43					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42754799	42754799	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42754799C>T	ENST00000310232.6	-	14	1811	c.1728G>A	c.(1726-1728)gaG>gaA	p.E576E		NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	576										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						TGCTGTTGCTCTCCTCCACCC	0.612000													12	117					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466838	56466838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56466838G>A	ENST00000291971.3	+	3	1485	c.1414G>A	c.(1414-1416)Gaa>Aaa	p.E472K	NLRP8_ENST00000590542.1_Missense_Mutation_p.E472K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	472	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GTTAGGTAAAGAAGATCTTGA	0.498000													42	110					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62144067	62144067	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62144067G>A	ENST00000433197.2	-	8	901	c.806C>T	c.(805-807)cCg>cTg	p.P269L		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	269					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						CTTGGGGAACGGGTACTTCCA	0.592000													16	29					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139416468	139416468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139416468G>A	ENST00000406875.3	-	2	460	c.366C>T	c.(364-366)ctC>ctT	p.L122L	HIPK2_ENST00000342645.6_Silent_p.L122L|HIPK2_ENST00000428878.2_Silent_p.L122L	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	122	Transcriptional corepression (By similarity).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					AGGTATCAAGGAGGCTCACAG	0.552000													12	26					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100159990	100159990	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:100159990G>A	ENST00000370575.4	-	5	388	c.340C>T	c.(340-342)Cga>Tga	p.R114*	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	114							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						TAGGGGTTTCGAAGATGAAGC	0.522000													20	44					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480281	73480281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73480281G>A	ENST00000523207.1	+	2	900	c.312G>A	c.(310-312)cgG>cgA	p.R104R		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	104					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			ATTTCTACCGGACCGGGAAAC	0.463000													29	64					0	0	1	0	0
INTS3	65123	broad.mit.edu	37	1	153724787	153724787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153724787C>T	ENST00000456435.1	+	8	1330	c.144C>T	c.(142-144)ctC>ctT	p.L48L	INTS3_ENST00000435409.2_Silent_p.L254L|INTS3_ENST00000318967.2_Silent_p.L254L|INTS3_ENST00000512605.1_Silent_p.L48L|INTS3_ENST00000476843.1_3'UTR			Q68E01	INT3_HUMAN	integrator complex subunit 3	255					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTCGGGATCTCGTAAGACTAC	0.428000													89	269					0	0	1	0	0
DNAJC1	64215	broad.mit.edu	37	10	22048148	22048148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:22048148G>A	ENST00000376980.3	-	11	1837	c.1547C>T	c.(1546-1548)tCc>tTc	p.S516F		NM_022365.3	NP_071760.2	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	516	SANT 2.				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(13)|skin(2)|upper_aerodigestive_tract(2)	21		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				GCGGTCAGAGGATCCCCTTGG	0.542000													49	185					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102995	22102995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22102995C>T	ENST00000542433.1	-	1	101	c.4G>A	c.(4-6)Gga>Aga	p.G2R		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TTGGTCTTTCCCATGTCTTTT	0.438000													25	92					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234041375	234041375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:234041375G>A	ENST00000366618.3	+	2	299	c.154G>A	c.(154-156)Gag>Aag	p.E52K		NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	0					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GGCGATTAAGGAGGATCTGAA	0.632000													24	74					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69684658	69684658	+	Missense_Mutation	SNP	C	C	T	rs144426334		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:69684658C>T	ENST00000370598.1	+	9	2350	c.1529C>T	c.(1528-1530)cCt>cTt	p.P510L		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	510					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ATTGCAGCACCTTATGAAATA	0.413000													7	65					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535774	27535774	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27535774G>A	ENST00000574842.1	+	0	255																											CGGGGGACAGGTCAGTGCCCA	0.498000													51	178					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82447513	82447513	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:82447513C>T	ENST00000370728.1	+	21	3768	c.3123C>T	c.(3121-3123)ttC>ttT	p.F1041F	LPHN2_ENST00000370723.1_Silent_p.F1043F|LPHN2_ENST00000335786.5_Silent_p.F1041F|LPHN2_ENST00000370715.1_Silent_p.F1028F|LPHN2_ENST00000370725.1_Silent_p.F1056F|LPHN2_ENST00000359929.3_Silent_p.F1028F|LPHN2_ENST00000394879.1_Silent_p.F1043F|LPHN2_ENST00000370727.1_Silent_p.F1056F|LPHN2_ENST00000370730.1_Silent_p.F1041F|LPHN2_ENST00000370717.2_Silent_p.F1056F|LPHN2_ENST00000319517.6_Silent_p.F1028F|LPHN2_ENST00000370713.1_Silent_p.F1028F|LPHN2_ENST00000370721.1_Silent_p.F966F|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000271029.4_Silent_p.F1056F			O95490	LPHN2_HUMAN	latrophilin 2	1041					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTGGCGCTTTCGCTCTTCTGT	0.383000													94	318					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808137	48808137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48808137C>T	ENST00000309835.3	+	1	375	c.365C>T	c.(364-366)tCc>tTc	p.S122F	STON1_ENST00000406226.1_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.S122F|STON1_ENST00000404752.1_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.S122F					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGAGAATCTTCCTTACTGCCT	0.473000													32	53					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139274303	139274303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139274303G>A	ENST00000298532.2	-	20	2881	c.2513C>T	c.(2512-2514)gCc>gTc	p.A838V		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	838					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGTGCTCTGGGCACTTGAGGA	0.602000													5	14					0	0	1	0	0
CWC27	10283	broad.mit.edu	37	5	64273001	64273001	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:64273001C>T	ENST00000381070.3	+	13	1409	c.1192C>T	c.(1192-1194)Caa>Taa	p.Q398*	CWC27_ENST00000545000.1_3'UTR	NM_005869.2	NP_005860.2	Q6UX04	CWC27_HUMAN	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	398					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(5)|prostate(1)	21						TAAACTCACTCAAGCAATTGC	0.333000													15	50					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473345	19473345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:19473345C>T	ENST00000507958.1	-	15	3353	c.2363G>A	c.(2362-2364)aGa>aAa	p.R788K	CDH18_ENST00000510297.1_5'UTR|CDH18_ENST00000382275.1_Missense_Mutation_p.R788K|CDH18_ENST00000274170.4_Missense_Mutation_p.R788K			Q13634	CAD18_HUMAN	cadherin 18, type 2	788					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTAAGTTGTTCTTTCAGATTC	0.428000													44	121					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22063225	22063225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:22063225G>A	ENST00000261200.4	-	8	1185	c.1186C>T	c.(1186-1188)Ctt>Ttt	p.L396F	ABCC9_ENST00000261201.4_Missense_Mutation_p.L396F|ABCC9_ENST00000345162.2_Missense_Mutation_p.L396F	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	396	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAGAGCCTAAGGATTTTATTA	0.328000													40	73					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56471297	56471297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56471297G>A	ENST00000370754.5	-	39	8029	c.8030C>T	c.(8029-8031)cCt>cTt	p.P2677L	DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Missense_Mutation_p.P2499L|DST_ENST00000421834.2_Intron|DST_ENST00000446842.2_Missense_Mutation_p.P2173L|DST_ENST00000370769.4_Missense_Mutation_p.P2499L|DST_ENST00000312431.6_Missense_Mutation_p.P2499L|DST_ENST00000244364.6_Intron			Q03001	DYST_HUMAN	dystonin	2499					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGAGCCAACAGGATTTAAATG	0.378000													20	52					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49823439	49823439	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49823439G>A	ENST00000561648.1	-	2	88	c.35C>T	c.(34-36)tCa>tTa	p.S12L	ZNF423_ENST00000562520.1_5'UTR|ZNF423_ENST00000563137.2_5'UTR|ZNF423_ENST00000262383.2_Missense_Mutation_p.S12L	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	12					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CGAGAAGTCTGAGGCCTCCCC	0.582000													23	35					0	0	1	0	0
LILRA6	79168	broad.mit.edu	37	19	54746089	54746089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54746089C>T	ENST00000440558.2	-	3	216	c.168G>A	c.(166-168)caG>caA	p.Q56Q	LILRA6_ENST00000270464.5_Silent_p.Q56Q|LILRA6_ENST00000245621.5_Silent_p.Q56Q|LILRA6_ENST00000396365.2_Silent_p.Q56Q|LILRA6_ENST00000419410.2_Silent_p.Q56Q|LILRB3_ENST00000407860.2_Silent_p.Q56Q|LILRA6_ENST00000391735.3_Silent_p.Q56Q					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTTGGTACTCCTGGGCCTCCA	0.592000													50	290					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760771	20760771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20760771C>T	ENST00000400451.2	+	5	1962	c.1448C>T	c.(1447-1449)tCc>tTc	p.S483F	ZNF74_ENST00000405993.1_Missense_Mutation_p.S451F|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Missense_Mutation_p.S483F	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	483					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCTTCAGCTCCCACGCCTAC	0.637000													28	90					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44684879	44684879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44684879G>A	ENST00000454036.1	+	22	3023	c.2947G>A	c.(2947-2949)Gct>Act	p.A983T	SLC12A5_ENST00000243964.3_Missense_Mutation_p.A960T	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	983					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGAAGAGACGGCTGGTGACAG	0.577000													26	54					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25419959	25419959	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25419959G>A	ENST00000549301.1	+	0	694				SNHG14_ENST00000441592.2_RNA																							ggcttcagcaggtccctccgt	0.478000													26	59					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44418361	44418361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44418361G>A	ENST00000269973.5	-	10	2317	c.1227C>T	c.(1225-1227)ggC>ggT	p.G409G	ZNF45_ENST00000589703.1_Silent_p.G409G|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	409					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G409G(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						CTCCAGTATGGCCTCTTTGAT	0.478000													33	101					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99438647	99438647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99438647C>T	ENST00000397899.2	-	7	2420	c.2089G>A	c.(2089-2091)Gat>Aat	p.D697N		NM_207362.2	NP_997245.2			KIAA1211-like																		GAGGCGCCATCCCTGTATTTG	0.637000													4	21					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123594271	123594271	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123594271G>A	ENST00000340011.5	+	3	1004	c.647G>A	c.(646-648)tGg>tAg	p.W216*	SPAM1_ENST00000460182.1_Nonsense_Mutation_p.W216*|SPAM1_ENST00000439500.1_Nonsense_Mutation_p.W216*|SPAM1_ENST00000223028.7_Nonsense_Mutation_p.W216*|SPAM1_ENST00000402183.2_Nonsense_Mutation_p.W216*	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	216					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	AATCACTTGTGGGGTTATTAT	0.373000													34	104					0	0	1	0	0
OR6C76	390326	broad.mit.edu	37	12	55820243	55820243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55820243C>T	ENST00000328314.3	+	1	206	c.206C>T	c.(205-207)tCa>tTa	p.S69L		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TTGGAAATTTCATTTACTTCT	0.393000													37	159					0	0	1	0	0
CRYGC	1420	broad.mit.edu	37	2	208993031	208993031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:208993031C>T	ENST00000282141.3	-	3	458	c.421G>A	c.(421-423)Ggg>Agg	p.G141R		NM_020989.3	NP_066269.1	P07315	CRGC_HUMAN	crystallin, gamma C	141	Beta/gamma crystallin 'Greek key' 4.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens			NS(1)|endometrium(1)|large_intestine(2)|lung(5)	9				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		TATTGCCGCCCCCGGTAGTTG	0.632000													37	88					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28883029	28883029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28883029C>T	ENST00000282397.4	-	28	3922	c.3671G>A	c.(3670-3672)aGa>aAa	p.R1224K	FLT1_ENST00000543394.1_Missense_Mutation_p.R247K|FLT1_ENST00000540678.1_Missense_Mutation_p.R442K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1224					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GGTTTTGATTCTTTCCAGGCT	0.408000													35	64					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71025230	71025230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71025230C>T	ENST00000393567.2	-	25	4005	c.3855G>A	c.(3853-3855)gtG>gtA	p.V1285V		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1285										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CATCTGAGATCACACTGGAAG	0.463000													28	87					0	0	1	0	0
RMI1	80010	broad.mit.edu	37	9	86617114	86617114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:86617114C>T	ENST00000325875.3	+	3	1545	c.1213C>T	c.(1213-1215)Cat>Tat	p.H405Y		NM_024945.2	NP_079221.2	Q9H9A7	RMI1_HUMAN	RecQ mediated genome instability 1	405					DNA replication	nucleus				biliary_tract(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						TTTTTCAGTTCATTGTAATGT	0.313000													45	67					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7681496	7681496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7681496G>A	ENST00000446248.2	+	16	3382	c.3281G>A	c.(3280-3282)aGg>aAg	p.R1094K	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.R1067K	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	1067					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						GGGGTGAAGAGGCCCACGTCT	0.612000													17	49					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17322773	17322773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17322773C>T	ENST00000594824.1	+	40	6275	c.6128C>T	c.(6127-6129)cCt>cTt	p.P2043L	MYO9B_ENST00000397274.2_3'UTR|MYO9B_ENST00000595618.1_3'UTR			Q13459	MYO9B_HUMAN	myosin IXB	2043	Tail.			TVAAPP -> PWPPLH (in Ref. 3; AAC26597).	actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						GTGGCCGCCCCTCCACGACGA	0.692000													7	8					0	0	1	0	0
OTX1	5013	broad.mit.edu	37	2	63282749	63282749	+	Silent	SNP	C	C	T	rs75832508		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:63282749C>T	ENST00000366671.3	+	5	639	c.363C>T	c.(361-363)tcC>tcT	p.S121S	OTX1_ENST00000282549.2_Silent_p.S121S	NM_001199770.1	NP_001186699.1	P32242	OTX1_HUMAN	orthodenticle homeobox 1	121						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					GCTCGGGCTCCGAAAGCAGTG	0.672000													9	79					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72458995	72458995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72458995C>T	ENST00000309731.7	-	7	534	c.521G>A	c.(520-522)aGg>aAg	p.R174K	GRAMD2_ENST00000564184.1_5'UTR	NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	174						integral to membrane				cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						GCAGACTCTCCTCAGCAGGTC	0.552000													13	99					0	0	1	0	0
MIR496	574454	broad.mit.edu	37	14	101526943	101526943	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101526943G>A	ENST00000385226.1	+	0	34					NR_030176.1																						GGTTGTCCATGGTGTGTTCAT	0.532000													3	10					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95602890	95602890	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95602890C>A	ENST00000343958.4	-	2	2393	c.2170G>T	c.(2170-2172)Gac>Tac	p.D724Y	FGD6_ENST00000546711.1_Missense_Mutation_p.D724Y|FGD6_ENST00000549499.1_Missense_Mutation_p.D724Y	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	724					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						AGCATTTGGTCATCCAAAGAC	0.463000													19	107					4.63292e-17	4.65879e-17	1	1	0
NTRK2	4915	broad.mit.edu	37	9	87482336	87482336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:87482336G>A	ENST00000304053.6	+	14	2106	c.1623G>A	c.(1621-1623)aaG>aaA	p.K541K	NTRK2_ENST00000323115.4_Silent_p.K525K|NTRK2_ENST00000376213.1_Silent_p.K525K|NTRK2_ENST00000277120.3_Silent_p.K541K|NTRK2_ENST00000376208.1_Silent_p.K525K|NTRK2_ENST00000376214.1_Silent_p.K541K	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	525	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						GTCAGCTCAAGCCAGACACAT	0.463000										TSP Lung(25;0.17)			41	157					0	0	1	0	0
KRTAP5-2	440021	broad.mit.edu	37	11	1619373	1619373	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1619373C>T	ENST00000412090.1	-	1	151	c.108G>A	c.(106-108)ggG>ggA	p.G36G	KRTAP5-AS1_ENST00000424148.1_RNA	NM_001004325.1	NP_001004325.1	Q701N4	KRA52_HUMAN	keratin associated protein 5-2	36						keratin filament				large_intestine(1)|lung(2)|skin(1)	4		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCACAGCCCCCACGGCCGG	0.687000													33	71					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3907853	3907853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3907853G>A	ENST00000450849.2	+	5	947	c.480G>A	c.(478-480)ggG>ggA	p.G160G	ATCAY_ENST00000600960.1_Silent_p.G160G|ATCAY_ENST00000301260.6_Silent_p.G160G|ATCAY_ENST00000398448.3_Silent_p.G166G	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	160					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		TGATCATCGGGGAGCAAGAGC	0.657000													23	41					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31876828	31876828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31876828C>T	ENST00000396184.3	-	12	1373	c.1169G>A	c.(1168-1170)tGg>tAg	p.W390*	PDE1C_ENST00000396191.1_Nonsense_Mutation_p.W390*|PDE1C_ENST00000321453.7_Nonsense_Mutation_p.W390*|PDE1C_ENST00000396193.1_Nonsense_Mutation_p.W450*|PDE1C_ENST00000396182.2_Nonsense_Mutation_p.W390*	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	390	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			TGACATTGTCCAGCGATGATG	0.428000													17	83					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225688361	225688361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:225688361G>A	ENST00000409592.3	-	28	3135	c.3022C>T	c.(3022-3024)Ccc>Tcc	p.P1008S	DOCK10_ENST00000258390.7_Missense_Mutation_p.P1014S			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1014							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGAGGCCGGGGAAGCTAAGGA	0.368000													26	76					0	0	1	0	0
CDC34	997	broad.mit.edu	37	19	532078	532078	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:532078C>T	ENST00000215574.4	+	1	365	c.147C>T	c.(145-147)ccC>ccT	p.P49P		NM_004359.1	NP_004350.1	P49427	UB2R1_HUMAN	cell division cycle 34	49					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(1)	2		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGGCCCCCCAACACCTACT	0.682000													3	12					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71778763	71778763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71778763G>A	ENST00000258104.3	+	19	1942	c.1665G>A	c.(1663-1665)cgG>cgA	p.R555R	DYSF_ENST00000410041.1_Silent_p.R573R|DYSF_ENST00000429174.2_Silent_p.R555R|DYSF_ENST00000409744.1_Silent_p.R542R|DYSF_ENST00000410020.3_Silent_p.R573R|DYSF_ENST00000394120.2_Silent_p.R556R|DYSF_ENST00000409366.1_Silent_p.R556R|DYSF_ENST00000409582.3_Silent_p.R572R|DYSF_ENST00000413539.2_Silent_p.R586R|DYSF_ENST00000409651.1_Silent_p.R587R|DYSF_ENST00000409762.1_Silent_p.R572R	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	555			R -> W (in isolated hyperCKemia, LGMD2B and MMD1).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATCGTGGCCGGCTTCTGCTCT	0.637000													6	15					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4242186	4242186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4242186C>T	ENST00000399609.3	-	6	1402	c.1390G>A	c.(1390-1392)Gaa>Aaa	p.E464K	SRL_ENST00000537996.1_Missense_Mutation_p.E422K	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	923	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity	p.E464K(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						TTTGGTGTTTCGCTACACCCT	0.557000													64	114					0	0	1	0	0
PTPN9	5780	broad.mit.edu	37	15	75761170	75761170	+	Silent	SNP	G	G	A	rs137863856	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75761170G>A	ENST00000306726.2	-	13	2234	c.1722C>T	c.(1720-1722)ttC>ttT	p.F574F		NM_002833.2	NP_002824.1	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type 9	574	Tyrosine-protein phosphatase.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCTTCTCTGCGAACTCCAGGA	0.542000													35	148					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197411416	197411416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197411416G>A	ENST00000367400.3	+	11	4134	c.3999G>A	c.(3997-3999)gaG>gaA	p.E1333E	CRB1_ENST00000367397.1_3'UTR|CRB1_ENST00000544212.1_Silent_p.E814E|CRB1_ENST00000538660.1_Silent_p.E797E|CRB1_ENST00000367399.2_Silent_p.E1221E|RP11-75C23.1_ENST00000422250.1_RNA|CRB1_ENST00000535699.1_Silent_p.E1309E	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1333	EGF-like 19; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGCGCTGCGAGGTGGACGTAA	0.488000													63	221					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19349166	19349166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19349166C>T	ENST00000252575.5	+	11	3398	c.3355C>T	c.(3355-3357)Cgc>Tgc	p.R1119C	NCAN_ENST00000538881.1_Missense_Mutation_p.R570C	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1119	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding	p.R1133S(1)|p.R1119S(1)		breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CTGCCGCCGCCGCTCCGGCCA	0.652000													27	86					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143104761	143104761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143104761C>T	ENST00000275815.3	-	2	179	c.93G>A	c.(91-93)atG>atA	p.M31I		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	31						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TGCTTGTGTCCATCAGAGTAA	0.562000													77	192					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129906709	129906709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129906709G>A	ENST00000368654.3	-	13	3770	c.3395C>T	c.(3394-3396)cCa>cTa	p.P1132L	MKI67_ENST00000368653.3_Missense_Mutation_p.P772L	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1132	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTCTGGTGGTGGAGATTTGCA	0.463000													158	395					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28136760	28136760	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28136760G>A	ENST00000316334.3	-	5	1143	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	338							zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		GAGCCACTTGGAAAATCTCTT	0.483000													31	93					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48589800	48589800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48589800C>T	ENST00000340553.3	+	5	918	c.657C>T	c.(655-657)caC>caT	p.H219H		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	219					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TATCACCTCACTATTTAAGCT	0.363000													12	79					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656881	40656881	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:40656881G>A	ENST00000406785.1	-	2	729	c.540C>T	c.(538-540)ttC>ttT	p.F180F	SLC8A1_ENST00000542024.1_Silent_p.F180F|SLC8A1_ENST00000542756.1_Silent_p.F180F|SLC8A1_ENST00000332839.4_Silent_p.F180F|SLC8A1_ENST00000405901.3_Silent_p.F180F|SLC8A1_ENST00000403092.1_Silent_p.F180F|SLC8A1_ENST00000405269.1_Silent_p.F180F|SLC8A1_ENST00000402441.1_Silent_p.F180F|SLC8A1_ENST00000408028.2_Silent_p.F180F|SLC8A1_ENST00000406391.2_Silent_p.F180F			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	180					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CAATAATGATGAACATATTGA	0.463000													16	50					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63276393	63276393	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63276393G>A	ENST00000415491.2	+	2	799	c.185G>A	c.(184-186)tGg>tAg	p.W62*	LGALS12_ENST00000340246.5_Nonsense_Mutation_p.W124*|LGALS12_ENST00000255684.5_Nonsense_Mutation_p.W123*|LGALS12_ENST00000425950.2_Nonsense_Mutation_p.W62*|LGALS12_ENST00000394618.3_Nonsense_Mutation_p.W123*	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	123	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						GAGGCCCGGTGGCCCCACCTG	0.592000													18	73					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58533821	58533821	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58533821C>A	ENST00000348616.4	+	1	340	c.40C>A	c.(40-42)Ctt>Att	p.L14I	CDH26_ENST00000244047.5_Missense_Mutation_p.L14I	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	14					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			gctgctgctgcttctagtgct	0.597000													7	29					2.7689e-08	2.77803e-08	1	1	0
CD27	939	broad.mit.edu	37	12	6554699	6554699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6554699G>A	ENST00000266557.3	+	2	475	c.246G>A	c.(244-246)gaG>gaA	p.E82E	CD27-AS1_ENST00000545339.1_RNA|CD27_ENST00000541233.1_3'UTR|CD27-AS1_ENST00000399492.2_RNA	NM_001242.4	NP_001233.1	P26842	CD27_HUMAN	CD27 molecule	82					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						CCCACTGTGAGAGCTGTCGGC	0.597000													6	41					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207640181	207640181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207640181C>T	ENST00000367057.3	+	2	558	c.369C>T	c.(367-369)tcC>tcT	p.S123S	CR2_ENST00000367058.3_Silent_p.S123S|CR2_ENST00000458541.2_Silent_p.S123S|CR2_ENST00000367059.3_Silent_p.S123S	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	123	Sushi 2.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						CCAACTTCTCCATGAACGGAA	0.458000													36	77					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227919409	227919409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227919409C>T	ENST00000396625.3	-	31	2968	c.2761G>A	c.(2761-2763)Gga>Aga	p.G921R	COL4A4_ENST00000329662.7_Missense_Mutation_p.G921R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	921	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCAGGCTTTCCTCTTTCTCCG	0.512000													20	60					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216296644	216296644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:216296644G>A	ENST00000354785.4	-	4	828	c.459C>T	c.(457-459)acC>acT	p.T153T	FN1_ENST00000443816.1_Silent_p.T153T|FN1_ENST00000357009.2_Silent_p.T153T|FN1_ENST00000323926.6_Silent_p.T153T|FN1_ENST00000446046.1_Silent_p.T153T|FN1_ENST00000426059.1_Silent_p.T153T|FN1_ENST00000356005.4_Silent_p.T153T|FN1_ENST00000432072.2_Silent_p.T153T|FN1_ENST00000336916.4_Silent_p.T153T|FN1_ENST00000345488.5_Silent_p.T153T|FN1_ENST00000346544.3_Silent_p.T153T|FN1_ENST00000421182.1_Silent_p.T153T|FN1_ENST00000359671.1_Silent_p.T153T|FN1_ENST00000357867.4_Silent_p.T153T			P02751	FINC_HUMAN	fibronectin 1	153	Fibrin- and heparin-binding 1.|Fibronectin type-I 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCTCCTCCAGGTGTCACCAA	0.463000													11	179					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	93225885	93225885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:93225885C>T	ENST00000282020.4	+	1	336	c.78C>T	c.(76-78)atC>atT	p.I26I	GRID2_ENST00000510992.1_Silent_p.I26I|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	26					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CGGATTCGATCATTCACATCG	0.502000													19	51					0	0	1	0	0
DOLPP1	57171	broad.mit.edu	37	9	131847378	131847378	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131847378C>T	ENST00000372546.4	+	3	286	c.254C>T	c.(253-255)cCc>cTc	p.P85L	DOLPP1_ENST00000406974.3_Missense_Mutation_p.P85L|DOLPP1_ENST00000540102.1_Intron	NM_020438.4	NP_065171.2	Q86YN1	DOPP1_HUMAN	dolichyldiphosphatase 1	85					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			endometrium(3)|kidney(2)|lung(7)|skin(1)	13						GAGCCACGGCCCTGTGGAGGT	0.632000													8	48					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56387438	56387438	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56387438G>A	ENST00000355701.3	-	21	4651	c.3781C>T	c.(3781-3783)Cag>Tag	p.Q1261*	BZRAP1_ENST00000268893.6_Nonsense_Mutation_p.Q1201*|BZRAP1_ENST00000343736.4_Nonsense_Mutation_p.Q1261*	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1261						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tcttcctcctGGATGTCTGAC	0.572000													36	59					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770252	53770252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53770252G>A	ENST00000311170.4	-	1	720	c.667C>T	c.(667-669)Ccc>Tcc	p.P223S		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	223					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GAGGCTCTGGGGGAGAGATTG	0.537000										HNSCC(26;0.072)			8	18					0	0	1	0	0
WDR92	116143	broad.mit.edu	37	2	68358422	68358422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:68358422G>A	ENST00000295121.6	-	8	1138	c.1022C>T	c.(1021-1023)tCa>tTa	p.S341L	WDR92_ENST00000492039.2_5'UTR	NM_138458.3	NP_612467.1	Q96MX6	WDR92_HUMAN	WD repeat domain 92	341					apoptosis|histone lysine methylation		methylated histone residue binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|stomach(1)	12						TTGGTCAAATGAACTACAGAC	0.463000													44	154					0	0	1	0	0
OTOP2	92736	broad.mit.edu	37	17	72926672	72926672	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72926672G>A	ENST00000331427.4	+	6	1034	c.942G>A	c.(940-942)gtG>gtA	p.V314V	OTOP2_ENST00000580223.1_Silent_p.V314V	NM_178160.2	NP_835454.1	Q7RTS6	OTOP2_HUMAN	otopetrin 2	314						integral to membrane				breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|prostate(4)|skin(1)|urinary_tract(2)	39	all_lung(278;0.172)|Lung NSC(278;0.207)					AGGTTCAAGTGAGCGGGGACG	0.602000													7	37					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74698746	74698746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:74698746G>A	ENST00000541184.1	-	2	688	c.211C>T	c.(211-213)Cca>Tca	p.P71S	ZDHHC15_ENST00000373367.3_Missense_Mutation_p.P80S|ZDHHC15_ENST00000373361.3_Missense_Mutation_p.P80S	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	80						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						GGCTGCTGTGGGAGTGTAAAG	0.348000													13	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179497405	179497405	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179497405C>T	ENST00000589042.1	-	235	43552	c.43328G>A	c.(43327-43329)gGa>gAa	p.G14443E	TTN_ENST00000342992.6_Missense_Mutation_p.G11875E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G12802E|TTN_ENST00000342175.6_Missense_Mutation_p.G5570E|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G5503E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G5378E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12802	Fibronectin type-III 4.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCTGGGTTCCTTTTAGCCA	0.418000													55	144					0	0	1	0	0
DYRK1A	1859	broad.mit.edu	37	21	38884476	38884476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38884476C>T	ENST00000339659.3	+	11	3377	c.1907C>T	c.(1906-1908)tCt>tTt	p.S636F	DYRK1A_ENST00000338785.3_3'UTR|DYRK1A_ENST00000398960.2_Missense_Mutation_p.S645F|DYRK1A_ENST00000455387.2_Missense_Mutation_p.S417F	NM_130436.2	NP_569120.1	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	645					nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			breast(4)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						ACCCAAGATTCTATGGAGGTT	0.522000													27	63					0	0	1	0	0
IL32	9235	broad.mit.edu	37	16	3119069	3119069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3119069G>A	ENST00000525643.2	+	7	612	c.280G>A	c.(280-282)Gat>Aat	p.D94N	IL32_ENST00000551513.1_Missense_Mutation_p.D131N|IL32_ENST00000528163.2_Missense_Mutation_p.D94N|IL32_ENST00000552936.1_Missense_Mutation_p.D118N|IL32_ENST00000552356.1_Missense_Mutation_p.D74N|IL32_ENST00000526464.2_Missense_Mutation_p.D94N|IL32_ENST00000549213.1_Missense_Mutation_p.D94N|IL32_ENST00000529550.1_Missense_Mutation_p.D94N|IL32_ENST00000530538.2_Missense_Mutation_p.D94N|IL32_ENST00000531965.1_Missense_Mutation_p.D84N|IL32_ENST00000396887.3_Missense_Mutation_p.D94N|IL32_ENST00000008180.9_Missense_Mutation_p.D74N|IL32_ENST00000440815.3_Missense_Mutation_p.D94N|IL32_ENST00000325568.5_Missense_Mutation_p.D94N|IL32_ENST00000548652.1_Missense_Mutation_p.D85N|IL32_ENST00000548246.1_Missense_Mutation_p.D54N|IL32_ENST00000533097.2_Missense_Mutation_p.D94N|IL32_ENST00000534507.1_Missense_Mutation_p.D140N|IL32_ENST00000548476.1_Missense_Mutation_p.D140N|IL32_ENST00000552664.1_Missense_Mutation_p.D94N|IL32_ENST00000396890.2_Missense_Mutation_p.D140N|IL32_ENST00000444393.3_Missense_Mutation_p.D94N|IL32_ENST00000382213.3_Missense_Mutation_p.D85N|IL32_ENST00000530890.1_Missense_Mutation_p.D74N|IL32_ENST00000551122.1_Missense_Mutation_p.D94N|IL32_ENST00000529699.1_Missense_Mutation_p.D74N			P24001	IL32_HUMAN	interleukin 32	140					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						GGATGTTGAGGATCCCGCAAC	0.567000													8	15					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138687872	138687872	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:138687872C>T	ENST00000520602.1	-	16	2022	c.1737_splice	c.e16+1	p.L579_splice	MCF2_ENST00000370573.4_Splice_Site_p.L519_splice|MCF2_ENST00000370578.4_Splice_Site_p.L664_splice|MCF2_ENST00000536274.1_Splice_Site_p.L480_splice|MCF2_ENST00000338585.6_Splice_Site_p.L535_splice|MCF2_ENST00000414978.1_Splice_Site_p.L579_splice|MCF2_ENST00000370576.4_Splice_Site_p.L519_splice|MCF2_ENST00000519895.1_Splice_Site_p.L595_splice			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	519	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					AGTCGCTTACCAACAAAACAG	0.363000													83	63					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137777709	137777709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137777709G>A	ENST00000350339.2	+	5	425	c.411G>A	c.(409-411)ctG>ctA	p.L137L	FCN2_ENST00000291744.6_Silent_p.L175L	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	175	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding	p.L175L(1)		breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		AGTTCTGGCTGGGGAATGACA	0.672000													20	42					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117885050	117885050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:117885050C>T	ENST00000439649.3	-	5	804	c.437G>A	c.(436-438)gGg>gAg	p.G146E	GFRA1_ENST00000355422.6_Missense_Mutation_p.G151E|GFRA1_ENST00000544592.1_Missense_Mutation_p.G30E|GFRA1_ENST00000369236.1_Missense_Mutation_p.G146E	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	151					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		GCAGTTGTTCCCTTTGGGAAT	0.537000													6	14					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127253129	127253129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127253129C>T	ENST00000341640.2	-	6	843	c.638G>A	c.(637-639)aGa>aAa	p.R213K	PAX4_ENST00000463946.1_Missense_Mutation_p.R211K|PAX4_ENST00000378740.2_Missense_Mutation_p.R213K|PAX4_ENST00000338516.3_Missense_Mutation_p.R221K	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	221					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						TTTGGCTCTTCTGTTGGAAAA	0.527000													12	61					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71348651	71348651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:71348651C>T	ENST00000392650.3	-	41	5719	c.5719G>A	c.(5719-5721)Ggt>Agt	p.G1907S	SDK2_ENST00000388726.3_Missense_Mutation_p.G1888S|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1907	Fibronectin type-III 13.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GTGCCGAAACCATAGTCGTTG	0.637000													4	21					0	0	1	0	0
TCP11	6954	broad.mit.edu	37	6	35086057	35086057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35086057C>T	ENST00000311875.5	-	10	1957	c.1540G>A	c.(1540-1542)Gag>Aag	p.E514K	TCP11_ENST00000412155.2_Missense_Mutation_p.E463K|TCP11_ENST00000373974.4_Missense_Mutation_p.E468K|TCP11_ENST00000418521.2_Missense_Mutation_p.E438K|TCP11_ENST00000244645.3_Missense_Mutation_p.E439K|TCP11_ENST00000373979.2_Missense_Mutation_p.E439K|TCP11_ENST00000444780.2_Missense_Mutation_p.E509K|TCP11_ENST00000512012.1_Missense_Mutation_p.E501K			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	501					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						CAAACAGACTCCACTTTTGTT	0.512000													11	109					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102071146	102071146	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102071146A>T	ENST00000549145.1	+	27	3201	c.3101A>T	c.(3100-3102)aAa>aTa	p.K1034I	MYBPC1_ENST00000360610.2_Missense_Mutation_p.K1021I|MYBPC1_ENST00000541119.1_Missense_Mutation_p.K991I|MYBPC1_ENST00000536007.1_Missense_Mutation_p.K984I|MYBPC1_ENST00000553190.1_Missense_Mutation_p.K1003I|MYBPC1_ENST00000547509.1_Missense_Mutation_p.K989I|MYBPC1_ENST00000547405.1_Missense_Mutation_p.K977I|MYBPC1_ENST00000545503.2_Missense_Mutation_p.K1003I|MYBPC1_ENST00000441232.1_Missense_Mutation_p.K1021I|MYBPC1_ENST00000392934.3_Missense_Mutation_p.K990I|MYBPC1_ENST00000361685.2_Missense_Mutation_p.K1028I|MYBPC1_ENST00000361466.2_Missense_Mutation_p.K1028I|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000551300.1_Missense_Mutation_p.K904I|MYBPC1_ENST00000550270.1_Missense_Mutation_p.K1021I|MYBPC1_ENST00000452455.2_Missense_Mutation_p.K1021I			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	1021					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						ACCATGACTAAAGAGAGTGCA	0.458000													14	30					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57641153	57641153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57641153G>A	ENST00000254181.4	+	4	1564	c.1110G>A	c.(1108-1110)caG>caA	p.Q370Q	USP29_ENST00000598197.1_Silent_p.Q370Q	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	370					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCAACATGCAGAATGATGCTC	0.358000													35	85					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49248976	49248976	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49248976C>T	ENST00000332955.2	-	2	688	c.141G>A	c.(139-141)gcG>gcA	p.A47A		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	47					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TGTGATGCTTCGCATCCAGGT	0.532000													47	106					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76712680	76712680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76712680C>T	ENST00000369950.3	-	12	1435	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	416					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AGCTGGGGTTCAACAGGAGGA	0.428000													5	46					0	0	1	0	0
PRR23C	389152	broad.mit.edu	37	3	138763135	138763135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138763135C>T	ENST00000413199.1	-	1	599	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	PRR23C_ENST00000502927.2_Missense_Mutation_p.E110K|MRPS22_ENST00000495075.1_Intron	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	110										breast(2)|lung(7)|skin(2)	11						CCTGAGCATTCGTCGACGGAG	0.647000													4	7					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48269424	48269424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48269424C>T	ENST00000435803.1	+	7	659	c.635C>T	c.(634-636)tCc>tTc	p.S212F		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	212					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGTTCTAGTTCCTTAATATCC	0.388000													76	185					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9371224	9371224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9371224G>A	ENST00000378501.2	+	14	1300	c.1285G>A	c.(1285-1287)Ggg>Agg	p.G429R	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.G429R|PLCB4_ENST00000278655.4_Missense_Mutation_p.G429R|PLCB4_ENST00000378493.1_Missense_Mutation_p.G429R|PLCB4_ENST00000334005.3_Missense_Mutation_p.G429R|PLCB4_ENST00000378473.3_Missense_Mutation_p.G429R	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	429	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AGATCTATTTGGGGATCTCCT	0.343000													15	31					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102951139	102951139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:102951139G>A	ENST00000504592.1	+	14	1990	c.1572G>A	c.(1570-1572)atG>atA	p.M524I	BANK1_ENST00000322953.4_Missense_Mutation_p.M539I|BANK1_ENST00000444316.2_Missense_Mutation_p.M509I|RP11-498M5.2_ENST00000505091.1_RNA|BANK1_ENST00000428908.1_Missense_Mutation_p.M406I|BANK1_ENST00000508653.1_Missense_Mutation_p.M406I|BANK1_ENST00000510950.1_3'UTR			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	539					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AAGGCCAAATGGAAAGAAGTC	0.398000													28	72					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78796447	78796447	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78796447C>T	ENST00000545128.1	+	16	2675	c.2137C>T	c.(2137-2139)Ctg>Ttg	p.L713L	PCSK5_ENST00000376752.4_Silent_p.L713L	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	713	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TGGATACTTTCTGAATGAAGA	0.478000													37	79					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43067772	43067772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43067772G>A	ENST00000267890.6	-	13	1667	c.1559C>T	c.(1558-1560)tCt>tTt	p.S520F		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	520					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		GGTGTTGGCAGAAGCAGGCTT	0.502000													33	90					0	0	1	0	0
PHF2	5253	broad.mit.edu	37	9	96420455	96420455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96420455C>T	ENST00000359246.4	+	10	1543	c.1176C>T	c.(1174-1176)ccC>ccT	p.P392P	PHF2_ENST00000375376.4_Intron	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	392					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		AGCAGCTGCCCCCTCATCTAG	0.557000													4	24					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980844	40980844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40980844C>T	ENST00000373198.3	-	10	1877	c.1642G>A	c.(1642-1644)Gaa>Aaa	p.E548K	PTPRT_ENST00000373187.1_Missense_Mutation_p.E548K|PTPRT_ENST00000373193.3_Missense_Mutation_p.E548K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E548K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E548K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E548K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E548K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	548	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGTGGGTTTCATTCCGGAGC	0.572000													10	104					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73462885	73462885	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73462885C>T	ENST00000252034.7	+	15	1197	c.799_splice	c.e15+1	p.F266_splice	ELN_ENST00000380576.5_Splice_Site_p.F266_splice|ELN_ENST00000458204.1_Splice_Site_p.F256_splice|ELN_ENST00000380575.4_Splice_Site_p.F256_splice|ELN_ENST00000320492.7_Splice_Site_p.F230_splice|ELN_ENST00000414324.1_Splice_Site_p.F261_splice|ELN_ENST00000380553.4_Splice_Site_p.F149_splice|ELN_ENST00000357036.5_Splice_Site_p.F271_splice|ELN_ENST00000429192.1_Splice_Site_p.F271_splice|ELN_ENST00000380584.4_Splice_Site_p.F252_splice|ELN_ENST00000358929.4_Splice_Site_p.F266_splice|ELN_ENST00000445912.1_Splice_Site_p.F266_splice|ELN_ENST00000380562.4_Splice_Site_p.F266_splice|ELN_ENST00000320399.6_Splice_Site_p.F266_splice	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	266	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding	p.F266F(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	cagcaAAGTTCGGTGAGTGCC	0.607000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						5	65					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79193782	79193782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79193782G>A	ENST00000269392.4	-	2	322	c.75C>T	c.(73-75)ctC>ctT	p.L25L	AZI1_ENST00000450824.2_Silent_p.L25L|AZI1_ENST00000575907.1_Silent_p.L25L|AZI1_ENST00000374782.3_Silent_p.L25L	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	25					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CAGGCGGAGGGAGACCTGTCA	0.677000													23	65					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205554035	205554035	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205554035G>A	ENST00000367147.4	+	5	984	c.891G>A	c.(889-891)agG>agA	p.R297R	MFSD4_ENST00000539267.1_Silent_p.R297R|MFSD4_ENST00000536357.1_Silent_p.R210R	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	297					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GCTGCCAAAGGAAGAACCTCA	0.587000											OREG0014158	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	138					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139424	90139424	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90139424C>T	ENST00000492446.1	+	0	222																											CAGAGAAAGCCCCTAAGTCCC	0.522000													43	231					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52586576	52586576	+	Missense_Mutation	SNP	G	G	A	rs144206846	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52586576G>A	ENST00000591504.1	-	9	989	c.715C>T	c.(715-717)Ctc>Ttc	p.L239F	CCDC68_ENST00000337363.4_Missense_Mutation_p.L239F|CCDC68_ENST00000432185.1_Missense_Mutation_p.L239F	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	239										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TGCTCCTGGAGAATGGAAATC	0.453000													26	73					0	0	1	0	0
GNLY	10578	broad.mit.edu	37	2	85924772	85924772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:85924772G>A	ENST00000409696.3	+	5	636	c.354G>A	c.(352-354)gaG>gaA	p.E118E	GNLY_ENST00000263863.4_Silent_p.E133E|GNLY_ENST00000524600.1_Silent_p.E160E	NM_012483.2	NP_036615.2	P22749	GNLY_HUMAN	granulysin	133	Saposin B-type.				cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space		p.E133E(1)		endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						AGATCTGTGAGGACCTCAGGT	0.542000													4	45					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149503946	149503946	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149503946C>T	ENST00000378016.2	+	0	8770							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTTCTGCGCCCCCGGCTGCAC	0.662000													5	12					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45028281	45028281	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45028281G>A	ENST00000454753.1	-	0	488							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				CTGCAATGGAGGGTTTGGCCA	0.522000													11	51					0	0	1	0	0
FAR2P1	440905	broad.mit.edu	37	2	130792786	130792786	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130792786C>T	ENST00000325390.3	-	0	2542					NR_026758.1																						AATTAAGTCTCCCACAGCCAT	0.468000													19	30					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57080136	57080136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57080136G>A	ENST00000532437.1	-	4	2337	c.2026C>T	c.(2026-2028)Cca>Tca	p.P676S	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.P676S			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	676	Acidic.|Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				TCAGGGCCTGGAGGCTCGGGG	0.662000													20	46					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153476190	153476190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:153476190G>A	ENST00000288670.9	+	15	2162	c.1795G>A	c.(1795-1797)Gga>Aga	p.G599R	FMNL2_ENST00000475377.2_5'UTR	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	599	Pro-rich.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						TCCGCTGCCTGGAACATCTTC	0.562000													10	22					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999796	112999796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112999796C>T	ENST00000271277.6	+	6	1907	c.1682C>T	c.(1681-1683)cCc>cTc	p.P561L	CTTNBP2NL_ENST00000607039.1_3'UTR|RP4-671G15.3_ENST00000508462.1_RNA	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	561						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCCTGAGCCCCCTGTCTCCA	0.557000													29	90					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076250	9076250	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9076250A>T	ENST00000397910.4	-	3	11399	c.11196T>A	c.(11194-11196)tcT>tcA	p.S3732S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3733	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGTGGACAGAGAATCAAACA	0.502000													20	84					0	0	1	0	0
GZMB	3002	broad.mit.edu	37	14	25101071	25101071	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:25101071G>A	ENST00000216341.4	-	4	699	c.593C>T	c.(592-594)tCc>tTc	p.S198F	GZMB_ENST00000382540.1_Missense_Mutation_p.S153F|GZMB_ENST00000382542.1_Missense_Mutation_p.S232F|RP11-104E19.1_ENST00000557736.1_RNA|GZMB_ENST00000526004.1_3'UTR|GZMB_ENST00000415355.3_Missense_Mutation_p.S186F|RP11-104E19.1_ENST00000555300.1_RNA			P10144	GRAB_HUMAN	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	198	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(4)|stomach(4)|urinary_tract(2)	13				GBM - Glioblastoma multiforme(265;0.028)		TACCTTAAAGGAAGTCTTTTT	0.473000													33	98					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47858339	47858339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47858339C>T	ENST00000328771.4	+	3	1098	c.749C>T	c.(748-750)aCc>aTc	p.T250I		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	250	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TCGGCGGCCACCAAGATTGTA	0.587000													17	94					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176905489	176905489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176905489C>T	ENST00000367654.2	-	15	2432	c.2419G>A	c.(2419-2421)Gaa>Aaa	p.E807K	ASTN1_ENST00000424564.2_Missense_Mutation_p.E799K|ASTN1_ENST00000367657.3_Missense_Mutation_p.E799K|ASTN1_ENST00000361833.2_Missense_Mutation_p.E799K|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	807					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CCAGACACTTCACTGAAGTTC	0.488000													34	50					0	0	1	0	0
TRIM25	7706	broad.mit.edu	37	17	54972922	54972922	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54972922G>A	ENST00000316881.4	-	7	1273	c.1224C>T	c.(1222-1224)gcC>gcT	p.A408A	TRIM25_ENST00000537230.1_Silent_p.A408A	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	408	Interaction with influenza A virus NS1.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					ACTGTTCCGGGGCTCCAAACG	0.517000													18	181					0	0	1	0	0
CCKBR	887	broad.mit.edu	37	11	6291949	6291949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6291949C>T	ENST00000525462.1	+	4	730	c.727C>T	c.(727-729)Cgc>Tgc	p.R243C	CCKBR_ENST00000334619.2_Missense_Mutation_p.R243C|CCKBR_ENST00000532715.1_Missense_Mutation_p.R159C			P32239	GASR_HUMAN	cholecystokinin B receptor	201					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GCTTATCTCTCGCGAGCTCTA	0.597000													38	67					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93902842	93902842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:93902842G>A	ENST00000412050.4	-	6	1443	c.1355C>T	c.(1354-1356)cCt>cTt	p.P452L	CPEB3_ENST00000265997.4_Missense_Mutation_p.P466L	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	466	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				TACTACGAGAGGTCCAAACCT	0.398000													22	57					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94931643	94931643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94931643G>A	ENST00000222381.3	-	8	1014	c.783C>T	c.(781-783)tcC>tcT	p.S261S	PON1_ENST00000542556.1_Silent_p.S261S	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	261					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TAAAGTCAAGGGACTTAAAAG	0.378000													6	54					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141079606	141079606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141079606G>A	ENST00000389484.3	-	82	13537	c.12566C>T	c.(12565-12567)cCt>cTt	p.P4189L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4189					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGCCCCAGAAGGATTTAGCAA	0.373000										TSP Lung(27;0.18)			15	60					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43259160	43259160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43259160G>A	ENST00000404209.4	-	4	1064	c.968C>T	c.(967-969)cCa>cTa	p.P323L	PSG8_ENST00000406636.3_Missense_Mutation_p.P201L|PSG8_ENST00000600709.1_Intron|PSG8_ENST00000306511.4_Missense_Mutation_p.P323L|PSG8_ENST00000401467.2_Missense_Mutation_p.P230L	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	323	Ig-like C2-type 2.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				CAGGGTGACTGGGTAACTGCG	0.478000													43	244					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012767	29012767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29012767G>A	ENST00000377175.1	-	1	250	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						AATTTCTGAGGAAAAAGTACA	0.433000													29	75					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49656793	49656793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49656793C>T	ENST00000252825.4	-	1	1888	c.1702G>A	c.(1702-1704)Gag>Aag	p.E568K	HRC_ENST00000595625.1_Missense_Mutation_p.E568K	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	568					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		tcttcctcctcGCTGTGGTCT	0.622000													10	12					0	0	1	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133953998	133953998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:133953998C>T	ENST00000298622.4	+	9	1526	c.1388C>T	c.(1387-1389)tCc>tTc	p.S463F		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GAAGAGGCTTCCCTGGAATCC	0.587000													8	26					0	0	1	0	0
ELAVL3	1995	broad.mit.edu	37	19	11577595	11577595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11577595G>A	ENST00000359227.3	-	2	481	c.57C>T	c.(55-57)ggC>ggT	p.G19G	ELAVL3_ENST00000438662.2_Silent_p.G19G|CTC-398G3.6_ENST00000585656.1_Silent_p.G173G	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	19					cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCAgggccgggccggccgggc	0.652000													9	29					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908493	164908493	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164908493C>T	ENST00000475390.1	-	2	569	c.126G>A	c.(124-126)gaG>gaA	p.E42E	SLITRK3_ENST00000241274.3_Silent_p.E42E			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	42						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CAAAACAGGGCTCATCTATTT	0.393000										HNSCC(40;0.11)			15	115					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2928182	2928182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:2928182C>T	ENST00000381130.2	+	2	204	c.204C>T	c.(202-204)ccC>ccT	p.P68P		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	68						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GCCGGTACCCCATCAGATCAG	0.483000													9	6					0	0	1	0	0
HEMGN	55363	broad.mit.edu	37	9	100692463	100692463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:100692463G>A	ENST00000259456.3	-	4	1357	c.1214C>T	c.(1213-1215)cCt>cTt	p.P405L		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	405					cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				GAGGTCTTCAGGCCCCGGTGT	0.433000													101	206					0	0	1	0	0
ADRA2C	152	broad.mit.edu	37	4	3769561	3769561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3769561G>A	ENST00000330055.5	+	1	1437	c.1228G>A	c.(1228-1230)Gag>Aag	p.E410K	ADRA2C_ENST00000509482.1_Intron	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	410					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CATCTGCCGCGAGGCCTGCCA	0.592000													18	26					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031688	79031688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79031688G>A	ENST00000446378.2	+	2	7131	c.7100G>A	c.(7099-7101)aGa>aAa	p.R2367K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2367						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAAGAGCCAAGAAGTGATCAA	0.368000													17	51					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141752717	141752717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141752717C>T	ENST00000475668.2	+	26	3146	c.3092C>T	c.(3091-3093)cCc>cTc	p.P1031L	MGAM_ENST00000549489.2_Missense_Mutation_p.P1031L			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1031					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AATGCCTTCCCCTCCACACCC	0.458000													20	70					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46656462	46656462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46656462C>T	ENST00000253255.5	-	1	2757	c.2758G>A	c.(2758-2760)Gat>Aat	p.D920N		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	920					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTTTCCTGATCATTTAACCAA	0.438000													69	159					0	0	1	0	0
BTN3A2	11118	broad.mit.edu	37	6	26368453	26368453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26368453C>T	ENST00000356386.2	+	3	231	c.43C>T	c.(43-45)Cat>Tat	p.H15Y	BTN3A2_ENST00000532994.1_Intron|BTN3A2_ENST00000377708.2_Missense_Mutation_p.H15Y|BTN3A2_ENST00000527422.1_Missense_Mutation_p.H15Y|BTN3A2_ENST00000508906.2_Intron|BTN3A2_ENST00000396948.1_Missense_Mutation_p.H15Y|BTN3A2_ENST00000396934.3_Intron	NM_001197246.2|NM_001197247.1|NM_007047.3	NP_001184175.1|NP_001184176.1|NP_008978.2	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2	15						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)	10						GCTCAACTTTCATGTCTCCCT	0.453000													53	105					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10941926	10941926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10941926G>A	ENST00000298232.7	-	13	1090	c.723C>T	c.(721-723)ttC>ttT	p.F241F	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.F221F|TPTE_ENST00000361285.4_Silent_p.F259F	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	259	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GATTTCTATAGAAAGACTGCC	0.313000													34	258					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49812809	49812809	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49812809C>T	ENST00000249601.4	-	1	329	c.34_splice	c.e1+1	p.R11_splice	ARHGAP22_ENST00000417912.2_Splice_Site_p.R11_splice|ARHGAP22_ENST00000491108.1_5'UTR|ARHGAP22_ENST00000435790.2_Intron	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	11					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TGGACTTACCCCTCCTGGCCT	0.612000													19	77					0	0	1	0	0
IL11	3589	broad.mit.edu	37	19	55877404	55877404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55877404C>T	ENST00000264563.2	-	5	633	c.571G>A	c.(571-573)Gga>Aga	p.G191R	IL11_ENST00000585513.1_Missense_Mutation_p.G191R|IL11_ENST00000590625.1_Missense_Mutation_p.G112R	NM_000641.3	NP_000632.1	P20809	IL11_HUMAN	interleukin 11	191					B cell differentiation|fat cell differentiation|megakaryocyte differentiation|negative regulation of hormone secretion|platelet activation|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity|growth factor activity|interleukin-11 receptor binding			large_intestine(1)|skin(1)	2	Breast(117;0.191)	Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)	Oprelvekin(DB00038)	AGCAGCAGTCCCCTCACGGCC	0.647000													7	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613737	179613737	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179613737C>T	ENST00000360870.5	-	46	13612	c.13390G>A	c.(13390-13392)Gaa>Aaa	p.E4464K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	592	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAATTTTTCAAATTCGATA	0.338000													22	69					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56226561	56226561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56226561G>A	ENST00000332836.2	-	6	2388	c.2361C>T	c.(2359-2361)tcC>tcT	p.S787S		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	787						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TGGAGTCACAGGAGACAGAGG	0.512000													14	38					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133799148	133799148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133799148C>T	ENST00000372338.4	-	4	1074	c.832G>A	c.(832-834)Gac>Aac	p.D278N	FIBCD1_ENST00000253018.4_Missense_Mutation_p.D120N|FIBCD1_ENST00000448616.1_Missense_Mutation_p.D278N|FIBCD1_ENST00000372337.2_Missense_Mutation_p.D120N	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	278	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CCGCCGCCGTCCGTGCGCATG	0.672000													8	25					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48797262	48797262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48797262G>A	ENST00000316623.5	-	16	2375	c.1920C>T	c.(1918-1920)ttC>ttT	p.F640F		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	640	EGF-like 10; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCAGTCCAGGGAAGCATTCAC	0.502000													50	132					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6479870	6479870	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6479870C>T	ENST00000381480.2	-	3	238	c.126_splice	c.e3+1	p.Q42_splice	DENND1C_ENST00000543576.1_Intron|DENND1C_ENST00000591030.1_5'UTR	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	42	UDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GCCTGAATACCTGGTCCCTGA	0.652000													12	21					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33894000	33894000	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33894000C>T	ENST00000307296.3	+	13	2039	c.1662C>T	c.(1660-1662)tcC>tcT	p.S554S	PDCD6IP_ENST00000457054.2_Silent_p.S559S			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	554	Interaction with EIAV p9.|Self-association.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						TCTTAAAATCCTTATTGTCAA	0.303000													5	45					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179076997	179076997	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179076997G>A	ENST00000502732.1	-	12	3608	c.3405C>T	c.(3403-3405)gcC>gcT	p.A1135A	ABL2_ENST00000511413.1_Silent_p.A1032A|ABL2_ENST00000367623.4_Silent_p.A1114A|ABL2_ENST00000408940.3_Silent_p.A1099A|ABL2_ENST00000504405.1_Silent_p.A996A|ABL2_ENST00000344730.3_Silent_p.A1017A|ABL2_ENST00000507173.1_Silent_p.A1011A|ABL2_ENST00000512653.1_Silent_p.A1120A	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	1135	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CCTCTCGGAAGGCAAATTTGT	0.537000			T	ETV6	AML								29	44					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82644405	82644405	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:82644405C>T	ENST00000533655.1	+	6	2237	c.2025C>T	c.(2023-2025)gcC>gcT	p.A675A	C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000329143.3_Silent_p.A374A|C11orf82_ENST00000430323.2_Silent_p.A675A|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	675					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						GCTATGATGCCTCTGCTGATC	0.348000													58	194					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23865591	23865591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23865591C>T	ENST00000405093.3	-	20	2401	c.2331G>A	c.(2329-2331)gaG>gaA	p.E777E	MYH6_ENST00000356287.3_Silent_p.E777E	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	777	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CATCCCGCATCTCCTCCAGCA	0.607000													5	55					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121341592	121341592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121341592C>T	ENST00000338040.4	+	3	1730	c.1316C>T	c.(1315-1317)tCc>tTc	p.S439F		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	439					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GAACAGTTTTCCTCTGGGACA	0.522000													29	97					0	0	1	0	0
KRT16P2	400578	broad.mit.edu	37	17	16735731	16735731	+	RNA	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:16735731A>T	ENST00000579062.1	-	0	225																											GCCCACCAGAAGCccatcacc	0.637000													26	44					0	0	1	0	0
WNT11	7481	broad.mit.edu	37	11	75902850	75902850	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75902850G>A	ENST00000322563.3	-	4	772	c.648C>T	c.(646-648)ggC>ggT	p.G216G	RP11-619A14.2_ENST00000527314.1_RNA	NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	216					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						TGGAGCAGGAGCCAGACACCC	0.642000													18	51					0	0	1	0	0
DUOXA1	90527	broad.mit.edu	37	15	45411507	45411507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45411507G>A	ENST00000558996.1	-	6	748	c.694C>T	c.(694-696)Cac>Tac	p.H232Y	DUOXA1_ENST00000430224.2_Missense_Mutation_p.H232Y|DUOXA1_ENST00000558422.1_Missense_Mutation_p.H232Y|DUOXA1_ENST00000560572.1_Missense_Mutation_p.H277Y|DUOXA1_ENST00000267803.4_Missense_Mutation_p.H277Y|DUOXA1_ENST00000559014.1_Missense_Mutation_p.H277Y	NM_001276267.1|NM_001276268.1	NP_001263196.1|NP_001263197.1	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	277					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		TTCAGCCTGTGAGGCTGCATC	0.582000													12	46					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44804027	44804027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44804027C>T	ENST00000309315.4	+	14	1993	c.1870C>T	c.(1870-1872)Ctg>Ttg	p.L624L	ZMIZ2_ENST00000441627.1_Silent_p.L624L|ZMIZ2_ENST00000433667.1_Silent_p.L592L|ZMIZ2_ENST00000413916.1_Silent_p.L566L|ZMIZ2_ENST00000265346.7_Silent_p.L598L	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	624					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GTGCTTTGACCTGGAGTCGTA	0.527000													18	53					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	169930250	169930250	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169930250G>A	ENST00000367765.1	-	18	3491	c.1990C>T	c.(1990-1992)Cga>Tga	p.R664*	KIFAP3_ENST00000367767.1_Nonsense_Mutation_p.R660*|KIFAP3_ENST00000538366.1_Nonsense_Mutation_p.R626*|KIFAP3_ENST00000540905.1_Nonsense_Mutation_p.R406*|KIFAP3_ENST00000361580.2_Nonsense_Mutation_p.R704*	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	704					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding	p.R704*(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGCTCAATTCGATCATCACCA	0.408000													36	67					0	0	1	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242742894	242742894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242742894C>T	ENST00000192314.6	+	4	641	c.510C>T	c.(508-510)ttC>ttT	p.F170F		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	170					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TGGACGCGTTCCTGGCCTCGC	0.627000													7	15					0	0	1	0	0
SUCNR1	56670	broad.mit.edu	37	3	151599232	151599232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151599232C>T	ENST00000362032.4	+	3	1006	c.901C>T	c.(901-903)Cac>Tac	p.H301Y	RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_033050.4	NP_149039.2	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	301						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	TTTGGGAGATCACTTCAGGGA	0.433000													46	108					0	0	1	0	0
RBM28	55131	broad.mit.edu	37	7	127954827	127954827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127954827G>A	ENST00000223073.1	-	17	2149	c.2035C>T	c.(2035-2037)Ccc>Tcc	p.P679S	RBM28_ENST00000481788.1_5'UTR|RBM28_ENST00000415472.2_Missense_Mutation_p.P538S	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	679					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						CTGATTTTGGGGCCTCGGTGT	0.532000													79	259					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929987	121929987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:121929987C>T	ENST00000265922.3	-	8	2122	c.1661G>A	c.(1660-1662)aGc>aAc	p.S554N	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		554					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GTCCAGGCTGCTGTTGCGCAT	0.567000													10	34					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37603671	37603671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37603671C>T	ENST00000328544.3	-	2	705	c.172G>A	c.(172-174)Ggc>Agc	p.G58S	SSTR3_ENST00000402501.1_Missense_Mutation_p.G58S	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	58					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						CCCAGCAGGCCCACCACGCAC	0.657000													40	105					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38230103	38230103	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38230103T>C	ENST00000339503.4	-	8	1615	c.1114A>G	c.(1114-1116)Aaa>Gaa	p.K372E	ZNF573_ENST00000590414.2_Missense_Mutation_p.K430E|ZNF573_ENST00000536220.1_Missense_Mutation_p.K342E|ZNF573_ENST00000392138.1_Missense_Mutation_p.K343E|ZNF573_ENST00000357309.3_Missense_Mutation_p.K342E	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TGATGTTGTTTAAGGTAGCCA	0.358000													73	179					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24689314	24689314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:24689314C>T	ENST00000396475.2	+	5	653	c.354C>T	c.(352-354)atC>atT	p.I118I	MPP6_ENST00000222644.4_Silent_p.I118I|MPP6_ENST00000409761.1_Silent_p.I6I	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	118					protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						ATTCTTCTATCAATAATCAGT	0.378000													29	83					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169512260	169512260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169512260C>T	ENST00000367796.3	-	13	2284	c.2083G>A	c.(2083-2085)Gaa>Aaa	p.E695K	F5_ENST00000367797.3_Missense_Mutation_p.E690K			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	690	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TATGAGTCTTCATCATCATCT	0.393000													43	170					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38530995	38530995	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38530995C>T	ENST00000332509.3	-	6	1077	c.894_splice	c.e6+1	p.E298_splice	PLA2G6_ENST00000335539.3_Splice_Site_p.E298_splice|PLA2G6_ENST00000402064.1_Splice_Site_p.E298_splice	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	298					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	ATCCACTCACCTCTGCGTTCT	0.662000													11	40					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66905896	66905896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:66905896G>A	ENST00000374690.3	+	3	2337	c.1813G>A	c.(1813-1815)Gat>Aat	p.D605N	AR_ENST00000396044.3_Missense_Mutation_p.D605N|AR_ENST00000504326.1_Missense_Mutation_p.D605N|AR_ENST00000396043.2_Missense_Mutation_p.D73N|AR_ENST00000513847.1_3'UTR	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	604	Interaction with HIPK3 (By similarity).				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TTGCACTATTGATAAATTCCG	0.413000									Androgen Insensitivity Syndrome				29	16					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130408766	130408766	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130408766G>A	ENST00000370904.1	-	24	4441	c.3531C>T	c.(3529-3531)ccC>ccT	p.P1177P	IGSF1_ENST00000370903.3_Silent_p.P1191P|IGSF1_ENST00000370910.1_Silent_p.P1177P|IGSF1_ENST00000361420.3_Silent_p.P1186P			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1186	Ig-like C2-type 12.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						CACCTGGCAGGGGTCCTCGGC	0.502000													88	57					0	0	1	0	0
GBP7	388646	broad.mit.edu	37	1	89618032	89618032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89618032C>T	ENST00000294671.2	-	5	682	c.544G>A	c.(544-546)Gat>Aat	p.D182N		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	182						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		AGGGTAAAATCTCGAACAGTC	0.468000													31	154					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136268834	136268834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136268834G>A	ENST00000371957.3	+	15	1592	c.1485G>A	c.(1483-1485)gtG>gtA	p.V495V	C9orf96_ENST00000371955.1_Silent_p.V28V	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	495							ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GTATCATTGTGAACAAGGCCC	0.617000													8	19					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71908145	71908145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71908145G>A	ENST00000258104.3	+	53	6238	c.5961G>A	c.(5959-5961)atG>atA	p.M1987I	DYSF_ENST00000410041.1_Missense_Mutation_p.M2005I|DYSF_ENST00000429174.2_Missense_Mutation_p.M2008I|DYSF_ENST00000409744.1_Missense_Mutation_p.M1995I|DYSF_ENST00000410020.3_Missense_Mutation_p.M2026I|DYSF_ENST00000394120.2_Missense_Mutation_p.M1988I|DYSF_ENST00000409366.1_Missense_Mutation_p.M2009I|DYSF_ENST00000409582.3_Missense_Mutation_p.M2025I|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Missense_Mutation_p.M2018I|DYSF_ENST00000409651.1_Missense_Mutation_p.M2019I|DYSF_ENST00000409762.1_Missense_Mutation_p.M2004I	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1987						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						AGCTGGAAATGACCTTGGAGA	0.572000													6	26					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526272	176526272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176526272C>T	ENST00000367662.3	+	2	1978	c.814C>T	c.(814-816)Ctg>Ttg	p.L272L	PAPPA2_ENST00000367661.3_Silent_p.L272L	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	272					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GCGGGAGCGGCTGCTGCTGCG	0.567000													12	38					0	0	1	0	0
FBXO3	26273	broad.mit.edu	37	11	33777415	33777415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:33777415G>A	ENST00000530401.1	-	5	585	c.565C>T	c.(565-567)Ctc>Ttc	p.L189F	FBXO3_ENST00000265651.3_Missense_Mutation_p.L194F|FBXO3_ENST00000526785.1_Missense_Mutation_p.L81F|FBXO3_ENST00000448981.2_Missense_Mutation_p.L194F|FBXO3_ENST00000534136.1_Missense_Mutation_p.L194F			Q9UK99	FBX3_HUMAN	F-box protein 3	194					proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		GTTAAAGGGAGACAGTATTTC	0.448000													30	38					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210187104	210187104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210187104C>T	ENST00000537238.1	+	4	465	c.74C>T	c.(73-75)tCa>tTa	p.S25L	SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000399639.2_Missense_Mutation_p.S63L|SYT14_ENST00000367019.1_Missense_Mutation_p.S63L|SYT14_ENST00000367015.1_Missense_Mutation_p.S25L|SYT14_ENST00000534859.1_Missense_Mutation_p.S63L|SYT14_ENST00000472886.1_Missense_Mutation_p.S63L|SYT14_ENST00000422431.1_Missense_Mutation_p.S108L	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	63						integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		GATCTTGGTTCAGAATACAGT	0.328000													43	126					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118374328	118374328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118374328C>T	ENST00000534358.1	+	27	7744	c.7721C>T	c.(7720-7722)gCc>gTc	p.A2574V	KMT2A_ENST00000354520.4_Missense_Mutation_p.A2533V|KMT2A_ENST00000389506.5_Missense_Mutation_p.A2571V	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGTCCAGTGGCCCAACCAAGC	0.473000													19	68					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373565	126373565	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126373565G>A	ENST00000394329.3	+	9	11407	c.11394G>A	c.(11392-11394)gtG>gtA	p.V3798V	FAT4_ENST00000335110.5_Silent_p.V2096V	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3798					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAGTAAAGGTGGAATCTGTGG	0.483000													11	54					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	122075631	122075631	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:122075631C>T	ENST00000265922.3	-	2	464	c.3G>A	c.(1-3)atG>atA	p.M1I	DBC1_ENST00000373964.2_Start_Codon_SNP_p.M1I	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		1					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						ACCTCCAGTTCATGCTTTTCT	0.453000													10	38					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70974910	70974910	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70974910G>A	ENST00000334414.6	-	10	2528	c.2484C>T	c.(2482-2484)ttC>ttT	p.F828F	PTPRB_ENST00000550358.1_Silent_p.F828F|PTPRB_ENST00000551525.1_Silent_p.F827F|PTPRB_ENST00000261266.5_Silent_p.F610F|PTPRB_ENST00000451516.2_Silent_p.F520F|PTPRB_ENST00000538708.1_Silent_p.F610F|PTPRB_ENST00000550857.1_Silent_p.F520F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	610	Fibronectin type-III 10.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGAGAGAGTGGAAGCTGTATC	0.473000													49	113					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047038	42047038	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42047038G>A	ENST00000372584.1	-	3	4445	c.3431C>T	c.(3430-3432)tCc>tTc	p.S1144F	HIVEP3_ENST00000429157.2_Missense_Mutation_p.S1144F|HIVEP3_ENST00000372583.1_Missense_Mutation_p.S1144F|HIVEP3_ENST00000247584.5_Missense_Mutation_p.S1144F	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1144					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGAGAAAAGGGAGACTGGTGG	0.587000													50	110					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71341895	71341895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71341895C>T	ENST00000260382.5	+	16	2265	c.2005C>T	c.(2005-2007)Cgc>Tgc	p.R669C	LRRC49_ENST00000544974.2_Missense_Mutation_p.R659C|LRRC49_ENST00000560691.1_Missense_Mutation_p.R375C|LRRC49_ENST00000443425.2_Missense_Mutation_p.R625C|LRRC49_ENST00000560369.1_Missense_Mutation_p.R674C|LRRC49_ENST00000560158.2_Missense_Mutation_p.R357C|LRRC49_ENST00000436542.2_3'UTR	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	669						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						CATAGAAATTCGCAATAAAAA	0.368000													9	183					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	13959964	13959964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:13959964C>T	ENST00000382080.1	-	7	1380	c.665G>A	c.(664-666)gGg>gAg	p.G222E	SGCZ_ENST00000421524.2_Missense_Mutation_p.G175E	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	209					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CACCTGGACCCCACGGGGAGC	0.463000													7	38					0	0	1	0	0
IL36B	27177	broad.mit.edu	37	2	113788732	113788732	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113788732C>T	ENST00000259213.4	-	3	121	c.13_splice	c.e3-1	p.R5_splice	IL36B_ENST00000327407.2_Splice_Site_p.R5_splice	NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	5					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						TGCTGCCTCCCCTGCCAGATG	0.458000													16	34					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94049590	94049590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94049590G>A	ENST00000297268.6	+	35	2596	c.2125G>A	c.(2125-2127)Gga>Aga	p.G709R		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	709			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	tggtcctCGGGGAAGCCCTGT	0.453000										HNSCC(75;0.22)			12	99					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124515299	124515299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124515299G>A	ENST00000296181.4	-	10	1925	c.1629C>T	c.(1627-1629)atC>atT	p.I543I	ITGB5_ENST00000488466.1_5'UTR	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	543	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		AAGGCCCATAGATCTTGCCAA	0.587000													18	124					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3729188	3729188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3729188G>A	ENST00000315677.3	-	7	2133	c.1538C>T	c.(1537-1539)tCg>tTg	p.S513L	DLGAP1_ENST00000400149.3_Missense_Mutation_p.S221L|DLGAP1_ENST00000581699.1_Missense_Mutation_p.S219L|DLGAP1_ENST00000400150.3_Missense_Mutation_p.S219L|DLGAP1_ENST00000400145.2_Missense_Mutation_p.S211L|DLGAP1_ENST00000581527.1_Missense_Mutation_p.S513L|DLGAP1_ENST00000539435.1_Missense_Mutation_p.S211L|DLGAP1_ENST00000478161.1_5'UTR|DLGAP1_ENST00000400155.1_Missense_Mutation_p.S219L|DLGAP1_ENST00000400147.2_Missense_Mutation_p.S211L|DLGAP1_ENST00000534970.1_Missense_Mutation_p.S225L|DLGAP1_ENST00000515196.2_Missense_Mutation_p.S513L|DLGAP1_ENST00000584874.1_Missense_Mutation_p.S513L	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	513					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CGGCGAGGACGACCTCAGGGA	0.682000													12	42					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32261345	32261345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32261345C>T	ENST00000375015.4	-	26	1302	c.1102G>A	c.(1102-1104)Gag>Aag	p.E368K	C6orf10_ENST00000447241.2_Missense_Mutation_p.E369K|C6orf10_ENST00000527965.1_Missense_Mutation_p.E353K|C6orf10_ENST00000533191.1_Missense_Mutation_p.E367K|C6orf10_ENST00000375007.4_Missense_Mutation_p.E367K|C6orf10_ENST00000442822.2_Missense_Mutation_p.E360K			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	369						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						TCACTCTTCTCTACCTGGGCT	0.493000													68	198					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576383	33576383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33576383G>A	ENST00000504830.1	-	19	4083	c.3748C>T	c.(3748-3750)Cct>Tct	p.P1250S	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.P1165S	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1250	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CCTCCCAGAGGGAGCAGAGTG	0.522000										HNSCC(64;0.19)			48	144					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53041993	53041993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53041993C>T	ENST00000309680.3	-	5	1107	c.1086G>A	c.(1084-1086)agG>agA	p.R362R		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	362	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CTTCCTTGCTCCTCTGGGCGA	0.582000													53	113					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356289	37356289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:37356289C>T	ENST00000217420.1	+	2	848	c.585C>T	c.(583-585)gcC>gcT	p.A195A		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	195					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CCTGCTGCGCCCCGCGCTTCC	0.637000													15	36					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11676363	11676363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:11676363C>T	ENST00000423059.3	-	2	667	c.416G>A	c.(415-417)aGc>aAc	p.S139N	THSD7A_ENST00000480061.1_5'UTR	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	139						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTTCTCTAGGCTTTTTGAAAT	0.458000										HNSCC(18;0.044)			21	54					0	0	1	0	0
C12orf36	283422	broad.mit.edu	37	12	13529186	13529186	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13529186G>A	ENST00000318426.2	-	2	371	c.154C>T	c.(154-156)Ctg>Ttg	p.L52L	C12orf36_ENST00000531049.1_5'UTR|C12orf36_ENST00000527705.2_Silent_p.L52L|C12orf36_ENST00000532841.1_Silent_p.L52L|C12orf36_ENST00000539026.1_Silent_p.L52L					chromosome 12 open reading frame 36											lung(3)|skin(3)	6				BRCA - Breast invasive adenocarcinoma(232;0.198)		cctccAAGCAGGTCAGAGAAC	0.498000													20	77					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5283101	5283101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5283101G>A	ENST00000546004.1	-	3	986	c.740C>T	c.(739-741)tCc>tTc	p.S247F	PROKR2_ENST00000217270.3_Missense_Mutation_p.S247F			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	247						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GAGCTCCCGGGAGATCCTGGC	0.582000										HNSCC(71;0.22)			25	60					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110835726	110835726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110835726G>A	ENST00000296632.3	-	6	610	c.476C>T	c.(475-477)cCa>cTa	p.P159L	STARD4_ENST00000512160.1_3'UTR	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	159	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		GTCTTTAAGTGGAACACAAAA	0.413000													34	79					0	0	1	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114450762	114450762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114450762C>T	ENST00000369563.3	+	3	933	c.487C>T	c.(487-489)Cac>Tac	p.H163Y	DCLRE1B_ENST00000466480.1_3'UTR	NM_022836.3	NP_073747.1	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B	163					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(6)|stomach(1)	18	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAAGCTGCCCACCAGATTGT	0.463000								Other identified genes with known or suspected DNA repair function					33	102					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24251645	24251645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24251645G>A	ENST00000538205.1	+	5	658	c.111G>A	c.(109-111)acG>acA	p.T37T	ADAMDEC1_ENST00000522298.1_Silent_p.T37T|ADAMDEC1_ENST00000256412.4_Silent_p.T116T|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	116					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		AAATTACCACGAAACCTGAGA	0.458000													19	39					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45134815	45134815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45134815C>T	ENST00000296129.1	-	6	1715	c.1581G>A	c.(1579-1581)gaG>gaA	p.E527E		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	527	CUB.					extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GCCTGGAGGCCTCTTGTTGGA	0.527000													32	73					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27877351	27877351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27877351G>A	ENST00000374011.2	-	6	2244	c.1276C>T	c.(1276-1278)Ctg>Ttg	p.L426L	AHDC1_ENST00000247087.5_Silent_p.L426L|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	426	Pro-rich.						DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GGTTCGGCCAGGGCAGCCACC	0.726000													4	10					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21687043	21687043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:21687043C>T	ENST00000444366.2	+	1	183	c.182C>T	c.(181-183)cCc>cTc	p.P61L	PAX1_ENST00000398485.2_Intron|PAX1_ENST00000460221.1_Intron			P15863	PAX1_HUMAN	paired box 1	84					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						GTTTTCTCCCCCTCCGGCTCA	0.667000													10	68					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228547304	228547304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228547304G>A	ENST00000284548.11	+	81	18785	c.18711G>A	c.(18709-18711)gaG>gaA	p.E6237E	OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000570156.2_Intron|OBSCN_ENST00000366709.4_Silent_p.E3356E			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6237					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCAGAGAAGAGACCATCACCA	0.647000													6	8					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142151420	142151420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142151420C>T	ENST00000519811.1	+	4	690	c.620C>T	c.(619-621)tCc>tTc	p.S207F	DENND3_ENST00000424248.1_Missense_Mutation_p.S127F|DENND3_ENST00000262585.2_Missense_Mutation_p.S127F|DENND3_ENST00000518347.1_Missense_Mutation_p.S207F			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	127	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GACTGCCTTTCCTGGTGAGCT	0.647000													7	109					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57761270	57761270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57761270C>T	ENST00000360716.3	+	16	2366	c.2145C>T	c.(2143-2145)tcC>tcT	p.S715S	CCDC135_ENST00000394337.4_Silent_p.S715S|CCDC135_ENST00000336825.8_Silent_p.S650S			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	715						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						TGACCATCTCCATCTATGACA	0.557000													46	93					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131922087	131922087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131922087C>T	ENST00000286355.5	-	6	3599	c.1507G>A	c.(1507-1509)Gat>Aat	p.D503N	ADCY8_ENST00000377928.3_Missense_Mutation_p.D503N	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	503					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ATGTCAACATCGTGTTTTGTC	0.478000										HNSCC(32;0.087)			17	91					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121384953	121384953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121384953G>A	ENST00000260197.7	+	8	1263	c.1134G>A	c.(1132-1134)gaG>gaA	p.E378E	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	378					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CAGAGGCAGAGGGGCTGAAGT	0.522000													6	92					0	0	1	0	0
RFPL1S	10740	broad.mit.edu	37	22	29833640	29833640	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29833640G>A	ENST00000461286.2	-	0	4736					NR_002727.2																						CCAATAAAACGCCCTCATGTG	0.522000													11	24					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348138	220348138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220348138G>A	ENST00000312358.7	+	30	6085	c.5953G>A	c.(5953-5955)Gag>Aag	p.E1985K	SPEG_ENST00000485813.1_3'UTR|AC053503.11_ENST00000429882.1_RNA	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1985					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCAGGACCAGGAGGCTCCCAG	0.711000													4	8					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31230642	31230642	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31230642G>A	ENST00000322122.3	+	4	803	c.519G>A	c.(517-519)ggG>ggA	p.G173G		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	173					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						GGGCCGTGGGGGAGCAGCTGG	0.667000													20	86					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70031747	70031747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70031747C>T	ENST00000355303.5	+	25	2945	c.2640C>T	c.(2638-2640)tcC>tcT	p.S880S	ANO1_ENST00000398543.2_Silent_p.S734S|ANO1_ENST00000538023.1_Silent_p.S880S|ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000530676.1_Silent_p.S734S|ANO1_ENST00000531349.1_Silent_p.S589S	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	880					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						ACGACATCTCCAAGGACTTCT	0.577000													16	80					0	0	1	0	0
KRT33B	3884	broad.mit.edu	37	17	39521143	39521143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39521143G>A	ENST00000251646.3	-	6	1034	c.985C>T	c.(985-987)Cgc>Tgc	p.R329C		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	329	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				AGGTCACTGCGGATCTCCGCC	0.627000													52	62					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120568516	120568516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120568516G>A	ENST00000300648.6	-	56	7617	c.7605C>T	c.(7603-7605)ctC>ctT	p.L2535L		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2535					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGTCTCATGAGAAAGCCCA	0.607000													6	66					0	0	1	0	0
IGHV2-26	28455	broad.mit.edu	37	14	106757818	106757818	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106757818C>T	ENST00000390611.2	-	0	212																											CCAGGGCCTTCCCTGGGGGCT	0.537000													27	58					0	0	1	0	0
CNKSR3	154043	broad.mit.edu	37	6	154727673	154727673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:154727673G>A	ENST00000607772.1	-	13	2027	c.1483C>T	c.(1483-1485)Cgg>Tgg	p.R495W	CNKSR3_ENST00000433165.2_Missense_Mutation_p.R320W|CNKSR3_ENST00000479339.1_Missense_Mutation_p.R415W	NM_173515.2	NP_775786.2	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	495	DUF1170.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	15		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		TCCGCACCCCGGACCAGATGC	0.557000													42	38					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125081671	125081671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125081671G>A	ENST00000522917.1	+	29	3995	c.3789G>A	c.(3787-3789)aaG>aaA	p.K1263K	FER1L6_ENST00000399018.1_Silent_p.K1263K|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1263						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAATGCTCAAGAAGAAACCCA	0.468000													19	51					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113102448	113102448	+	Missense_Mutation	SNP	G	G	A	rs55757519		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113102448G>A	ENST00000316851.7	+	9	1141	c.1141G>A	c.(1141-1143)Gga>Aga	p.G381R	NCAM1_ENST00000533760.1_Missense_Mutation_p.G263R|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Missense_Mutation_p.G390R	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	391	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane		p.G390*(2)|p.G381*(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		CACTGATGCCGGAGAGTACAT	0.592000													30	76					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27506194	27506194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27506194G>A	ENST00000356183.4	-	16	2683	c.2668C>T	c.(2668-2670)Ccc>Tcc	p.P890S	GTF3C1_ENST00000561623.1_Missense_Mutation_p.P890S	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	890						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGGATTGGGGGGATGTAGCGC	0.562000													7	39					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10747052	10747052	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10747052C>T	ENST00000586078.1	+	15	1396	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	SLC44A2_ENST00000335757.5_Silent_p.F429F|SLC44A2_ENST00000407327.4_Silent_p.F427F	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	429					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GTTGCCAGTTCGCCTTCTACG	0.602000													33	67					0	0	1	0	0
UGT1A7	54577	broad.mit.edu	37	2	234590739	234590739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234590739G>A	ENST00000373426.3	+	1	156	c.156G>A	c.(154-156)ggG>ggA	p.G52G	UGT1A10_ENST00000344644.5_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Intron	NM_019077.2	NP_061950.2														NS(1)|endometrium(6)|kidney(5)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|prostate(1)|skin(1)	33		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCCTCAGGGGGCATGAGGTGG	0.547000													10	174					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377997	113377997	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113377997G>A	ENST00000316407.4	-	7	2942	c.2532C>T	c.(2530-2532)ttC>ttT	p.F844F	KIAA2018_ENST00000478658.1_Silent_p.F844F|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	844					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						ACACAGCAGGGAAGCTTTCTA	0.473000													18	50					0	0	1	0	0
MYOG	4656	broad.mit.edu	37	1	203054621	203054621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203054621C>T	ENST00000241651.4	-	1	543	c.469G>A	c.(469-471)Ggg>Agg	p.G157R		NM_002479.4	NP_002470.2	P15173	MYOG_HUMAN	myogenin (myogenic factor 4)	157					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|urinary_tract(1)	12						CCACTTACCCCTGGCTGGGGC	0.697000													3	18					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86258507	86258507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:86258507G>A	ENST00000263857.6	-	30	4902	c.4524C>T	c.(4522-4524)atC>atT	p.I1508I	POLR1A_ENST00000409681.1_Intron			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1508					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						TGAACGGGTGGATCTCACGCA	0.677000													62	155					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107674717	107674717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107674717C>T	ENST00000388781.3	-	31	4837	c.4754G>A	c.(4753-4755)cGg>cAg	p.R1585Q	LAMB4_ENST00000205386.4_Missense_Mutation_p.R1585Q|LAMB4_ENST00000483484.1_5'UTR|LAMB4_ENST00000388780.3_Missense_Mutation_p.R1585Q	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1585	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						AGAGTTTGCCCGTCCTTGAGT	0.338000													55	132					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52232540	52232540	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:52232540G>A	ENST00000356297.4	-	23	4403	c.4303C>T	c.(4303-4305)Ccc>Tcc	p.P1435S	RP11-401H2.1_ENST00000521294.1_RNA|PXDNL_ENST00000543296.1_3'UTR	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1435	VWFC.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGGGACAGGGAGCCGGGGGA	0.483000													7	15					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26655803	26655803	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26655803C>T	ENST00000256737.3	+	19	2778	c.1926C>T	c.(1924-1926)ttC>ttT	p.F642F	ANO3_ENST00000537978.1_Silent_p.F626F|ANO3_ENST00000525139.1_Silent_p.F626F|ANO3_ENST00000531568.1_Silent_p.F496F	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	642						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						TGAAGATGTTCCTCTTCCAGT	0.393000													7	57					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3424448	3424448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3424448G>A	ENST00000356575.4	-	14	1926	c.1700C>T	c.(1699-1701)tCc>tTc	p.S567F	MEGF6_ENST00000294599.4_Missense_Mutation_p.S462F	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	567	EGF-like 10.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		ACAGCTGCAGGAGAAGCTGCA	0.602000													21	54					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51449363	51449363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:51449363G>A	ENST00000522124.1	+	11	1336	c.675G>A	c.(673-675)ttG>ttA	p.L225L	SNTG1_ENST00000517473.1_Silent_p.L225L|SNTG1_ENST00000276467.5_Silent_p.L225L|SNTG1_ENST00000518864.1_Silent_p.L225L	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	225					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GCACAGATTTGAGTCGGTGAG	0.453000													19	166					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192594	152192594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152192594C>T	ENST00000368801.2	-	3	1586	c.1511G>A	c.(1510-1512)gGt>gAt	p.G504D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	504					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGTCGTTCACCCCTAGATGA	0.552000													108	336					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108315553	108315553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:108315553C>T	ENST00000520734.1	-	4	536	c.251G>A	c.(250-252)aGa>aAa	p.R84K	ANGPT1_ENST00000520052.1_Missense_Mutation_p.R83K|ANGPT1_ENST00000518386.1_Intron			Q15389	ANGP1_HUMAN	angiopoietin 1	284					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGCACAGTCTCTAAATGGTTT	0.313000													33	71					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7645572	7645572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:7645572G>A	ENST00000340209.4	+	5	802	c.505G>A	c.(505-507)Gaa>Aaa	p.E169K	RBFOX1_ENST00000422070.4_Missense_Mutation_p.E207K|RBFOX1_ENST00000547338.1_Missense_Mutation_p.E164K|RBFOX1_ENST00000547372.1_Missense_Mutation_p.E207K|RBFOX1_ENST00000355637.4_Missense_Mutation_p.E184K|RBFOX1_ENST00000553186.1_Missense_Mutation_p.E164K|RBFOX1_ENST00000436368.2_Missense_Mutation_p.E184K|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000311745.5_Missense_Mutation_p.E184K|RBFOX1_ENST00000552089.1_Missense_Mutation_p.E181K|RBFOX1_ENST00000550418.1_Missense_Mutation_p.E164K			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	164	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						CGTAACTTTCGAAAATAGTGC	0.453000													41	91					0	0	1	0	0
LIMS1	3987	broad.mit.edu	37	2	109276190	109276190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:109276190C>T	ENST00000393310.1	+	2	293	c.126C>T	c.(124-126)ttC>ttT	p.F42F	LIMS1_ENST00000409441.1_Silent_p.F79F|LIMS1_ENST00000338045.3_Silent_p.F42F|LIMS1_ENST00000544547.1_Silent_p.F54F|LIMS1_ENST00000332345.6_Silent_p.F42F|LIMS1_ENST00000410093.1_Silent_p.F46F|LIMS1_ENST00000393314.2_Silent_p.F104F|LIMS1_ENST00000462817.1_3'UTR|LIMS1_ENST00000542845.1_Silent_p.F104F	NM_001193488.1	NP_001180417.1	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	42	LIM zinc-binding 1.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	10						CTCAGTGCTTCCAGCAGTTCC	0.577000													19	98					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2967781	2967781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2967781C>T	ENST00000520002.1	-	44	7065	c.6510G>A	c.(6508-6510)ctG>ctA	p.L2170L	CSMD1_ENST00000542608.1_Silent_p.L2169L|CSMD1_ENST00000400186.3_Silent_p.L2170L|CSMD1_ENST00000602557.1_Silent_p.L2170L|CSMD1_ENST00000537824.1_Silent_p.L2169L|CSMD1_ENST00000602723.1_Silent_p.L2170L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2170	CUB 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCAGTCCTTCAGGATCGGAT	0.493000													4	29					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423159	56423159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56423159G>A	ENST00000588751.1	-	5	2048	c.2024C>T	c.(2023-2025)tCa>tTa	p.S675L	NLRP13_ENST00000342929.3_Missense_Mutation_p.S675L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	675							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TAGGCAAAATGAAGAAGCTTG	0.403000													16	171					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39425938	39425938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39425938C>T	ENST00000280481.7	+	11	7074	c.6858C>T	c.(6856-6858)tcC>tcT	p.S2286S		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2286	Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAAAGGTTTCCATTGTGAGAG	0.507000													22	62					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71103356	71103356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71103356G>A	ENST00000393567.2	-	14	1938	c.1788C>T	c.(1786-1788)ccC>ccT	p.P596P	HYDIN_ENST00000538248.1_Silent_p.P623P|HYDIN_ENST00000321489.5_Silent_p.P596P|HYDIN_ENST00000448089.2_Silent_p.P596P|HYDIN_ENST00000448691.1_Silent_p.P596P|HYDIN_ENST00000288168.10_Silent_p.P613P|HYDIN_ENST00000393550.2_Silent_p.P611P|HYDIN_ENST00000541601.1_Silent_p.P613P|HYDIN_ENST00000543639.1_5'UTR	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	596										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TGTAAGTCATGGGGATCAAAG	0.443000													11	38					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819408	43819408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43819408G>A	ENST00000382031.1	+	5	6482	c.6451G>A	c.(6451-6453)Gaa>Aaa	p.E2151K	MAP1A_ENST00000399453.1_Missense_Mutation_p.E1913K|MAP1A_ENST00000300231.5_Missense_Mutation_p.E1913K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1913						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCGCAAGGCTGAAGGGGAAAG	0.597000													21	71					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999049	143999049	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143999049G>A	ENST00000323110.2	-	1	210	c.208C>T	c.(208-210)Cag>Tag	p.Q70*		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	70					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TGGAAGGTCTGGTGCATCTCC	0.637000									Familial Hyperaldosteronism type I				29	62					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75869049	75869049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:75869049G>A	ENST00000377636.3	-	18	3603	c.3257C>T	c.(3256-3258)cCc>cTc	p.P1086L	TBC1D4_ENST00000431480.2_Missense_Mutation_p.P1078L|TBC1D4_ENST00000425511.1_Missense_Mutation_p.P250L|TBC1D4_ENST00000478591.1_5'UTR|TBC1D4_ENST00000377625.2_Missense_Mutation_p.P1023L	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1086	Rab-GAP TBC.					cytoplasm	Rab GTPase activator activity	p.P1086L(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GAGGAACCAGGGGGCAGCATA	0.393000													18	84					0	0	1	0	0
CTSS	1520	broad.mit.edu	37	1	150722495	150722495	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150722495G>A	ENST00000368985.3	-	6	1040	c.780C>T	c.(778-780)ttC>ttT	p.F260F	CTSS_ENST00000448301.2_Silent_p.F210F|CTSS_ENST00000480760.1_Intron	NM_001199739.1|NM_004079.4	NP_001186668.1|NP_004070.3	P25774	CATS_HUMAN	cathepsin S	260					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	15	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTGTAGAGGAAGAAAGAAG	0.393000													15	48					0	0	1	0	0
SIRT2	22933	broad.mit.edu	37	19	39384092	39384092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39384092G>A	ENST00000249396.7	-	4	489	c.188C>T	c.(187-189)aCc>aTc	p.T63I	SIRT2_ENST00000358931.5_Missense_Mutation_p.T63I|SIRT2_ENST00000392081.2_Missense_Mutation_p.T26I	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	63					cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			CCCTTCCAAGGTCAGCTCGTC	0.612000													13	28					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95372892	95372892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95372892C>T	ENST00000371447.3	+	1	548	c.410C>T	c.(409-411)cCa>cTa	p.P137L		NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	137	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				GTTGTGTTTCCATTGGACATT	0.527000													12	63					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41161948	41161948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41161948C>T	ENST00000263413.3	-	10	1569	c.1305G>A	c.(1303-1305)caG>caA	p.Q435Q	C6_ENST00000337836.5_Silent_p.Q435Q|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	435	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCTCTGCTCCCTGTATAAATG	0.398000													29	65					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159820456	159820456	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159820456C>T	ENST00000497452.1	-	0	517																											GTATGGAGTTCGAAAAGCAAT	0.408000													10	31					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219868840	219868840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219868840C>T	ENST00000341552.5	-	33	5472	c.5389G>A	c.(5389-5391)Gag>Aag	p.E1797K	CCDC108_ENST00000453220.1_Missense_Mutation_p.E1797K|AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000441968.1_Missense_Mutation_p.E1797K	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1797	Glu-rich.					integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		tcctccttctcctctatctcc	0.567000													11	100					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137727469	137727469	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137727469C>T	ENST00000314358.5	+	8	2348	c.2148C>T	c.(2146-2148)agC>agT	p.S716S	KDM3B_ENST00000542866.1_Intron|KDM3B_ENST00000394866.1_Silent_p.S372S	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	716	Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						GGGGCCCAAGCCTCTCTGCCA	0.572000													27	73					0	0	1	0	0
TMEM133	83935	broad.mit.edu	37	11	100863262	100863262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100863262C>T	ENST00000303130.2	+	1	452	c.223C>T	c.(223-225)Cct>Tct	p.P75S		NM_032021.2	NP_114410.1	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	75						integral to membrane				kidney(2)|large_intestine(1)|lung(1)|prostate(1)	5		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		CATTCTGTGTCCTGCCTGTCT	0.378000													41	186					0	0	1	0	0
ABCG2	9429	broad.mit.edu	37	4	89052351	89052351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89052351C>T	ENST00000237612.3	-	5	938	c.393G>A	c.(391-393)atG>atA	p.M131I	ABCG2_ENST00000515655.1_Missense_Mutation_p.M131I	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	131	ABC transporter.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	TCAGAGTGCCCATCACAACAT	0.378000													23	111					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107744	55107744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55107744G>A	ENST00000251372.3	+	7	1231	c.1049G>A	c.(1048-1050)gGg>gAg	p.G350E	LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000453777.1_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	350	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		CAGTCATGGGGGCCGTTCCAC	0.582000													41	86					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69265641	69265641	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:69265641C>T	ENST00000551568.1	-	4	414	c.354G>A	c.(352-354)cgG>cgA	p.R118R	CPM_ENST00000546373.1_Silent_p.R118R|CPM_ENST00000338356.3_Silent_p.R118R	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	118					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TGATGTGTATCCGGGTACTAT	0.463000													33	109					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1742181	1742181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1742181G>A	ENST00000381241.3	+	2	418	c.219G>A	c.(217-219)ctG>ctA	p.L73L	ASMT_ENST00000381233.3_Silent_p.L73L|ASMT_ENST00000381229.4_Silent_p.L73L	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	73					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGAAGCTGCTGAAAGTGGAGA	0.592000													10	37					0	0	1	0	0
TNIP1	10318	broad.mit.edu	37	5	150436378	150436378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150436378G>A	ENST00000389378.2	-	6	1164	c.576C>T	c.(574-576)aaC>aaT	p.N192N	TNIP1_ENST00000523200.1_Silent_p.N192N|TNIP1_ENST00000522226.1_Silent_p.N192N|TNIP1_ENST00000521591.1_Silent_p.N192N|TNIP1_ENST00000315050.7_Silent_p.N192N|TNIP1_ENST00000524280.1_Silent_p.N192N|TNIP1_ENST00000523338.1_Silent_p.N192N|TNIP1_ENST00000520931.1_Silent_p.N139N|TNIP1_ENST00000518977.1_Silent_p.N192N	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	192	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGCCAGTCGGTTGAACTCCA	0.667000													6	48					0	0	1	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074281	46074281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46074281G>A	ENST00000391618.1	-	1	295	c.251C>T	c.(250-252)tCc>tTc	p.S84F	TSPEAR_ENST00000323084.4_Intron	NM_198698.1	NP_941971.1	P60329	KR124_HUMAN	keratin associated protein 12-4	84	15 X 5 AA approximate repeats.					keratin filament				lung(4)|ovary(1)|prostate(1)	6						TGGGCAGAAGGAAGCCACACA	0.647000													21	43					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15713626	15713626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15713626C>T	ENST00000378076.3	-	8	1176	c.823G>A	c.(823-825)Gag>Aag	p.E275K		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	275					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CCAGTAAACTCCCCAGCAGCA	0.353000													17	50					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197703506	197703506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:197703506G>A	ENST00000330198.4	+	5	491	c.469G>A	c.(469-471)Gat>Aat	p.D157N	LMLN_ENST00000482695.1_Missense_Mutation_p.D105N|LMLN_ENST00000332636.5_Missense_Mutation_p.D105N|LMLN_ENST00000420910.2_Missense_Mutation_p.D157N	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	157					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GAAGGAAAACGATCCTCACAG	0.438000													86	98					0	0	1	0	0
SLC17A1	6568	broad.mit.edu	37	6	25811976	25811976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25811976G>A	ENST00000244527.4	-	9	1035	c.920C>T	c.(919-921)cCc>cTc	p.P307L	SLC17A1_ENST00000468082.1_Missense_Mutation_p.P253L|SLC17A1_ENST00000427328.1_Missense_Mutation_p.P253L|SLC17A1_ENST00000476801.1_Missense_Mutation_p.P307L	NM_005074.3	NP_005065.2	Q14916	NPT1_HUMAN	solute carrier family 17 (organic anion transporter), member 1	307					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	36						AAACAAATAGGGAAGGGAAGA	0.433000													19	86					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45475275	45475275	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:45475275C>T	ENST00000361462.2	+	5	2892	c.2709C>T	c.(2707-2709)tcC>tcT	p.S903S	KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Silent_p.S903S|FAM179B_ENST00000382233.2_Silent_p.S903S			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	903							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						CGCCATCTTCCCGACGAGGTC	0.418000													42	146					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823648	38823648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38823648C>T	ENST00000303592.3	-	2	748	c.490G>A	c.(490-492)Gac>Aac	p.D164N		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	164		Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium (By similarity).			synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					ATGAAGGAGTCGATGACGCAG	0.627000													6	75					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119961497	119961497	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119961497G>A	ENST00000327554.2	+	11	1568		c.e11-1		RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60											endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TGTGTCCACAGCCGCACTAAT	0.567000													5	50					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8146431	8146431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8146431G>A	ENST00000315684.8	-	2	76	c.69C>T	c.(67-69)atC>atT	p.I23I	CTC1_ENST00000581671.1_Intron	NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	23					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						GGGTCTTTTGGATGAAGACCT	0.473000													15	22					0	0	1	0	0
EPPIN	57119	broad.mit.edu	37	20	44174367	44174367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44174367C>T	ENST00000354280.4	-	2	200	c.134G>A	c.(133-135)aGg>aAg	p.R45K	EPPIN_ENST00000409554.1_Missense_Mutation_p.R45K|EPPIN-WFDC6_ENST00000504988.1_Missense_Mutation_p.R45K|EPPIN_ENST00000555685.1_Missense_Mutation_p.R45K|EPPIN_ENST00000336443.3_Missense_Mutation_p.R29K	NM_020398.3	NP_065131.1			epididymal peptidase inhibitor																		ACACACATCCCTTTCTTGGAA	0.433000													71	133					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25260919	25260919	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25260919G>A	ENST00000354454.3	+	21	2254	c.1425G>A	c.(1423-1425)gaG>gaA	p.E475E	LRMP_ENST00000548766.1_Silent_p.E475E|LRMP_ENST00000547044.1_Silent_p.E475E	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	531					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					CACAGCAAGAGGACTCATGGA	0.483000													27	100					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52813459	52813459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52813459G>A	ENST00000273283.2	+	5	446	c.422G>A	c.(421-423)aGa>aAa	p.R141K	ITIH1_ENST00000540715.1_5'UTR|ITIH1_ENST00000542827.1_Missense_Mutation_p.R141K	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	141	VIT.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GCCTCGGGGAGAACTATGGAG	0.507000													18	31					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12774193	12774193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12774193G>A	ENST00000456935.2	-	6	887	c.847C>T	c.(847-849)Cgc>Tgc	p.R283C	MAN2B1_ENST00000221363.4_Missense_Mutation_p.R283C	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	283					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TCGGGGCTGCGAGGGTCCTCC	0.567000													35	73					0	0	1	0	0
LOC643201	643201	broad.mit.edu	37	5	175572124	175572124	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:175572124C>T	ENST00000515403.1	-	0	2993				RP11-826N14.4_ENST00000510029.1_lincRNA	NR_036494.1																						AGGTTTACTTCCTGAAGAATG	0.413000													5	27					0	0	1	0	0
OSGIN1	29948	broad.mit.edu	37	16	83999347	83999347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:83999347C>T	ENST00000343939.2	+	7	1801	c.1418C>T	c.(1417-1419)tCc>tTc	p.S473F	OSGIN1_ENST00000393306.1_Missense_Mutation_p.S390F|OSGIN1_ENST00000361711.3_Missense_Mutation_p.S390F			Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	473					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity			autonomic_ganglia(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12						TTTGGGGTCTCCCTGGTGCTG	0.647000													7	61					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39974767	39974767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39974767G>A	ENST00000321562.4	+	4	819	c.715G>A	c.(715-717)Gag>Aag	p.E239K		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	239	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GGCCTATGGCGAGAAAGGCTA	0.547000													4	14					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77465424	77465424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77465424C>T	ENST00000282849.5	-	3	681	c.263G>A	c.(262-264)cGa>cAa	p.R88Q	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	88					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CTGCGCCGATCGCTTTTTCCT	0.483000													48	278					0	0	1	0	0
RNF214	257160	broad.mit.edu	37	11	117152902	117152902	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117152902C>T	ENST00000530849.1	+	10	1173	c.1163C>T	c.(1162-1164)tCt>tTt	p.S388F	RNF214_ENST00000300650.4_Missense_Mutation_p.S543F|RNF214_ENST00000531452.1_Missense_Mutation_p.S543F|RNF214_ENST00000524917.1_Intron|RNF214_ENST00000531287.1_Missense_Mutation_p.S388F			Q8ND24	RN214_HUMAN	ring finger protein 214	543							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		GTTAAGGCTTCTGCTGAAACT	0.592000													28	201					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043180	56043180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56043180C>T	ENST00000313033.2	+	1	152	c.66C>T	c.(64-66)acC>acT	p.T22T		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					CTGAAGTCACCATGTTTATAT	0.299000													28	148					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940425	113940425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113940425C>T	ENST00000245796.6	+	2	587	c.392C>T	c.(391-393)tCa>tTa	p.S131L	PSD4_ENST00000441564.2_Missense_Mutation_p.S131L|PSD4_ENST00000465917.1_3'UTR	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	131					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AACACAGCATCACCAGGGTCA	0.622000													6	88					0	0	1	0	0
SLC36A1	206358	broad.mit.edu	37	5	150856304	150856304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150856304C>T	ENST00000243389.3	+	9	1199	c.976C>T	c.(976-978)Ctg>Ttg	p.L326L	SLC36A1_ENST00000520701.1_Silent_p.L326L|SLC36A1_ENST00000521925.1_Silent_p.L326L	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	326					cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	AACCCTCAACCTGCCCAACTG	0.498000													15	42					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108012092	108012092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108012092G>A	ENST00000280758.5	+	10	2917	c.2389G>A	c.(2389-2391)Gag>Aag	p.E797K	BTBD11_ENST00000420571.2_Intron|BTBD11_ENST00000490090.2_Missense_Mutation_p.E797K|BTBD11_ENST00000357167.4_Missense_Mutation_p.E334K	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	797						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GGCCCTGAGGGAGGCCATGTA	0.627000													11	34					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48266576	48266576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48266576G>A	ENST00000225964.5	-	40	3008	c.2890C>T	c.(2890-2892)Cct>Tct	p.P964S		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	964	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	CTCTGACCAGGCAGGCCGACC	0.617000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						5	30					0	0	1	0	0
OR1I1	126370	broad.mit.edu	37	19	15198326	15198326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15198326G>A	ENST00000209540.2	+	1	536	c.450G>A	c.(448-450)atG>atA	p.M150I		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						CATCATGGATGATCACCAACC	0.562000													15	43					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61769308	61769308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:61769308C>T	ENST00000423902.2	+	34	7948	c.7469C>T	c.(7468-7470)tCg>tTg	p.S2490L	CHD7_ENST00000529472.1_3'UTR|CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2490					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GCAGGCCTTTCGCGCACACCC	0.478000													33	165					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118865039	118865039	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:118865039G>A	ENST00000295622.1	+	1	43	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	1										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		GGCAGGAAATGGAAGAGCCTC	0.617000													5	24					0	0	1	0	0
IRX4	50805	broad.mit.edu	37	5	1879722	1879722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1879722C>T	ENST00000505790.1	-	5	1088	c.632G>A	c.(631-633)cGg>cAg	p.R211Q	IRX4_ENST00000231357.2_Missense_Mutation_p.R211Q|IRX4_ENST00000513692.1_Missense_Mutation_p.R211Q|IRX4_ENST00000505938.1_5'UTR	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	211					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		GCACTTGTTCCGCGGCGGCCA	0.662000													9	79					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292793	4292793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4292793C>T	ENST00000301272.2	-	5	697	c.652G>A	c.(652-654)Ggc>Agc	p.G218S	TMIGD2_ENST00000600349.1_Missense_Mutation_p.G46S|TMIGD2_ENST00000600114.1_Missense_Mutation_p.G98S|TMIGD2_ENST00000595645.1_Missense_Mutation_p.G214S	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	218						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGCTCTGGCCCCTCTGGTCC	0.642000													22	87					0	0	1	0	0
ADA	100	broad.mit.edu	37	20	43257798	43257798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43257798G>A	ENST00000372874.4	-	3	242	c.108C>T	c.(106-108)atC>atT	p.I36I	ADA_ENST00000537820.1_Silent_p.I36I	NM_000022.2	NP_000013.2	P00813	ADA_HUMAN	adenosine deaminase	36					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(2)|prostate(3)|skin(2)|urinary_tract(1)	18		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	CTGGGAGGGCGATCCCTCTCC	0.597000									Adenosine Deaminase Deficiency				21	42					0	0	1	0	0
ELF2	1998	broad.mit.edu	37	4	139988877	139988877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:139988877G>A	ENST00000394235.2	-	7	1040	c.538C>T	c.(538-540)Cct>Tct	p.P180S	ELF2_ENST00000510408.1_Missense_Mutation_p.P120S|ELF2_ENST00000379550.1_Missense_Mutation_p.P192S|ELF2_ENST00000265495.4_Missense_Mutation_p.P180S|ELF2_ENST00000379549.2_Intron|ELF2_ENST00000358635.3_Missense_Mutation_p.P132S	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	192					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					CCTAACTCAGGAGACCCATTG	0.363000													43	99					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307140	140307140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140307140C>T	ENST00000253807.2	+	1	663	c.663C>T	c.(661-663)atC>atT	p.I221I	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHAC1_ENST00000409700.3_Silent_p.I221I|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGTCACCATCATTGTGGTGG	0.582000													12	47					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1116178	1116178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1116178C>T	ENST00000379290.1	+	8	866	c.693C>T	c.(691-693)acC>acT	p.T231T	TTLL10_ENST00000379289.1_Silent_p.T231T|TTLL10_ENST00000379288.3_Silent_p.T158T			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	231	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGCTCAGCACCCTTCGGGGAC	0.692000													8	15					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903304	6903304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:6903304C>T	ENST00000486284.1	+	1	503	c.229C>T	c.(229-231)Cac>Tac	p.H77Y	GRM7_ENST00000403881.1_Missense_Mutation_p.H77Y|GRM7_ENST00000389336.4_Missense_Mutation_p.H77Y|GRM7_ENST00000402647.2_Missense_Mutation_p.H77Y|GRM7_ENST00000357716.4_Missense_Mutation_p.H77Y	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	77					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AAACGGGATCCACAGGCTGGA	0.647000													5	25					0	0	1	0	0
C3P1	388503	broad.mit.edu	37	19	10165979	10165979	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10165979G>A	ENST00000495140.1	+	0	1607																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						CACCTCCAAGGGGAACCCAGG	0.592000													16	61					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908728	103908728	+	Missense_Mutation	SNP	G	G	A	rs148474807	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103908728G>A	ENST00000302259.3	+	1	1421	c.1178G>A	c.(1177-1179)cGa>cAa	p.R393Q	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	393					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GATTCAGGACGAAAAGAGCAT	0.428000													9	52					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36348818	36348818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36348818C>T	ENST00000360631.3	-	17	2288	c.2077G>A	c.(2077-2079)Gag>Aag	p.E693K	DCLK1_ENST00000379893.1_Missense_Mutation_p.E386K|DCLK1_ENST00000255448.4_Silent_p.R717R			O15075	DCLK1_HUMAN	doublecortin-like kinase 1	693					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		ACCTGCCTCTCCTTATCAAGA	0.512000													3	10					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383741	108383741	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108383741C>T	ENST00000265843.4	-	6	2603	c.2493G>A	c.(2491-2493)caG>caA	p.Q831Q	EXPH5_ENST00000428840.1_Silent_p.Q755Q|EXPH5_ENST00000443411.1_Silent_p.Q643Q|EXPH5_ENST00000525344.1_Silent_p.Q824Q	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	831					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CAGTTAATTCCTGGTGACAAC	0.388000													54	138					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78071109	78071109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78071109C>T	ENST00000397545.4	+	19	3114	c.3087C>T	c.(3085-3087)tcC>tcT	p.S1029S		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1029					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGAGCAGCTCCCTCCTAGAGA	0.562000													15	84					0	0	1	0	0
PBX4	80714	broad.mit.edu	37	19	19681534	19681534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19681534C>T	ENST00000251203.8	-	3	588	c.302G>A	c.(301-303)aGa>aAa	p.R101K		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	101							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						CGCTCCTCCTCTTCCTCTCTT	0.597000													26	70					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145303970	145303970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145303970C>T	ENST00000342960.5	+	9	1402	c.1367C>T	c.(1366-1368)tCa>tTa	p.S456L	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Missense_Mutation_p.S185L|NBPF10_ENST00000369339.2_Missense_Mutation_p.S185L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	456										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GTGCAGAAATCATCTGCCCCC	0.438000													56	353					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	371314	371314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:371314G>A	ENST00000342640.4	-	6	686	c.644C>T	c.(643-645)cCt>cTt	p.P215L	THEG_ENST00000346878.2_Missense_Mutation_p.P191L	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	215					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCCAGACAGGAGTCGTCCT	0.597000													69	138					0	0	1	0	0
CPD	1362	broad.mit.edu	37	17	28788251	28788251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:28788251C>T	ENST00000225719.4	+	18	3628	c.3552C>T	c.(3550-3552)tgC>tgT	p.C1184C	CPD_ENST00000543464.2_Silent_p.C937C|CPD_ENST00000584051.1_3'UTR	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	1184	Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						ACACAAGCTGCTGTTACTTTC	0.378000													34	48					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55002508	55002508	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:55002508C>T	ENST00000474759.1	+	28	2529	c.2481C>T	c.(2479-2481)ttC>ttT	p.F827F	CACNA2D3_ENST00000490478.1_Silent_p.F733F|CACNA2D3_ENST00000288197.5_Silent_p.F827F|CACNA2D3_ENST00000415676.2_Silent_p.F827F	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	827						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTGAATTTTTCCAAAGGAAGT	0.368000													4	14					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51261233	51261233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:51261233G>A	ENST00000395542.2	-	3	483	c.299C>T	c.(298-300)cCa>cTa	p.P100L	COBL_ENST00000441453.1_Missense_Mutation_p.P100L|COBL_ENST00000265136.7_Missense_Mutation_p.P100L|COBL_ENST00000395540.2_Missense_Mutation_p.P100L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	100										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					ATGGTGGGATGGATTCAGGTG	0.418000													7	83					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26482151	26482151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26482151G>A	ENST00000265944.5	+	32	4622	c.4456G>A	c.(4456-4458)Gag>Aag	p.E1486K	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1486					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TAAAGGAGAGGAGCCAAAAAT	0.353000													19	53					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123599975	123599975	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:123599975C>T	ENST00000340011.5	+	5	1839	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	SPAM1_ENST00000460182.1_Silent_p.F494F|SPAM1_ENST00000439500.1_Silent_p.F494F|SPAM1_ENST00000223028.7_Silent_p.F494F|SPAM1_ENST00000402183.2_Silent_p.F494F	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	494					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	CCACAATGTTCATTGTTAGTA	0.368000													30	76					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41062004	41062004	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41062004G>A	ENST00000352632.3	+	25	5185	c.5099G>A	c.(5098-5100)cGg>cAg	p.R1700Q	SPTBN4_ENST00000392025.1_Missense_Mutation_p.R443Q|SPTBN4_ENST00000598249.1_Missense_Mutation_p.R1700Q|SPTBN4_ENST00000392023.1_Missense_Mutation_p.R376Q|SPTBN4_ENST00000595535.1_Missense_Mutation_p.R1700Q|SPTBN4_ENST00000338932.3_Missense_Mutation_p.R1700Q			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1700					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CAGATCAGCCGGCGGCAGTCT	0.662000													4	23					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88380164	88380164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:88380164G>A	ENST00000298699.2	-	10	1027	c.847C>T	c.(847-849)Cat>Tat	p.H283Y	C12orf50_ENST00000550553.1_Missense_Mutation_p.H244Y	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	283										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						CCTTTAAAATGAGGCTTCTTC	0.323000													18	43					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56246777	56246777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56246777C>T	ENST00000361673.3	-	4	1444	c.1231G>A	c.(1231-1233)Ggg>Agg	p.G411R		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	411							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTCCTCACCCCAACTTCTTGG	0.572000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	45					0	0	1	0	0
RHPN2	85415	broad.mit.edu	37	19	33517487	33517487	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33517487G>A	ENST00000254260.3	-	3	272	c.237C>T	c.(235-237)ttC>ttT	p.F79F	RHPN2_ENST00000400226.4_5'UTR	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	79					signal transduction	perinuclear region of cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					CTGAGTTGACGAAGCTCAGCT	0.562000													113	68					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20974824	20974824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20974824G>A	ENST00000261383.3	-	53	10381	c.10382C>T	c.(10381-10383)cCt>cTt	p.P3461L	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3461					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCAAGACCCAGGGAGTTGCTC	0.532000													9	53					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30686936	30686936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30686936C>T	ENST00000534862.1	+	13	1679	c.1316C>T	c.(1315-1317)cCa>cTa	p.P439L	HCK_ENST00000375862.2_Missense_Mutation_p.P458L|HCK_ENST00000518730.1_Missense_Mutation_p.P437L|HCK_ENST00000538448.1_Missense_Mutation_p.P438L|HCK_ENST00000375852.2_Missense_Mutation_p.P459L|HCK_ENST00000520553.1_Missense_Mutation_p.P438L	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	459	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ATCCCTTACCCAGGTAGGGAA	0.542000													37	112					0	0	1	0	0
DIRAS2	54769	broad.mit.edu	37	9	93375997	93375997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:93375997G>A	ENST00000375765.3	-	2	501	c.113C>T	c.(112-114)cCg>cTg	p.P38L		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	38					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity	p.P38Q(1)		kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						TTCCACCGTCGGGATGTAGCT	0.577000													28	161					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52306893	52306893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52306893G>A	ENST00000550683.1	+	2	215	c.114G>A	c.(112-114)gtG>gtA	p.V38V	ACVRL1_ENST00000419526.2_Intron|ACVRL1_ENST00000388922.4_Silent_p.V24V	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	24					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GAGACCCTGTGAAGCCGTCTC	0.657000													7	9					0	0	1	0	0
SLC25A18	83733	broad.mit.edu	37	22	18070755	18070755	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18070755G>A	ENST00000327451.5	+	9	1178	c.640G>A	c.(640-642)Gag>Aag	p.E214K	AC004019.13_ENST00000443935.1_RNA|SLC25A18_ENST00000399813.1_Missense_Mutation_p.E214K	NM_031481.1	NP_113669.1	Q9H1K4	GHC2_HUMAN	solute carrier family 25 (glutamate carrier), member 18	214						integral to membrane|mitochondrial inner membrane	binding|symporter activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	18				Lung(27;0.124)	L-Glutamic Acid(DB00142)	GGGGTTCAACGAGCTCGCCGG	0.532000													47	101					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004526	41004526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41004526G>A	ENST00000399564.4	-	37	4566	c.4116C>T	c.(4114-4116)atC>atT	p.I1372I	MROH2B_ENST00000506092.2_Silent_p.I927I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GCAGCTCCAGGATTTTTTTTA	0.438000													36	114					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73063793	73063793	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73063793G>A	ENST00000429829.1	-	0	8795					NR_001564.2																						CACCAGAAGGGGCCTTGGAGG	0.398000													8	8					0	0	1	0	0
C1orf158	93190	broad.mit.edu	37	1	12819318	12819318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12819318C>T	ENST00000288048.5	+	3	517	c.301C>T	c.(301-303)Cat>Tat	p.H101Y	C1orf158_ENST00000376210.3_Missense_Mutation_p.H63Y	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	101										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CTATGACGACCATTACAACCG	0.567000													74	166					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7976167	7976167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7976167G>A	ENST00000319144.4	-	15	2288	c.2028C>T	c.(2026-2028)atC>atT	p.I676I		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	676	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						TGCGCTGGCGGATGTCGTGTG	0.602000										Multiple Myeloma(8;0.094)			6	50					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306867	54306867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54306867G>A	ENST00000545554.1	+	1	1767	c.1767G>A	c.(1765-1767)agG>agA	p.R589R	UNC13C_ENST00000537900.1_Silent_p.R589R|UNC13C_ENST00000260323.11_Silent_p.R589R			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	589					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TATGGCAGAGGAAACAGGAAG	0.463000													26	51					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211735	38211735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38211735G>A	ENST00000379705.3	-	11	3096	c.2239C>T	c.(2239-2241)Cgc>Tgc	p.R747C	TRPC4_ENST00000338947.5_Missense_Mutation_p.R574C|TRPC4_ENST00000358477.2_Missense_Mutation_p.R747C|TRPC4_ENST00000379681.3_Missense_Mutation_p.R752C|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379673.2_Missense_Mutation_p.R682C|TRPC4_ENST00000379679.1_Missense_Mutation_p.R574C|TRPC4_ENST00000355779.2_Intron			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	747	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACTTCAAAGCGGAAACTAGAA	0.363000													20	64					0	0	1	0	0
AKR7L	246181	broad.mit.edu	37	1	19593689	19593689	+	RNA	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19593689T>C	ENST00000420396.2	-	0	903				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						TTTTTCCAAATACTTCCATCC	0.418000													9	14					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713148	70713148	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70713148C>T	ENST00000530196.1	-	0	1370					NR_003951.1																						CCACACCATTCCCACAGCGCT	0.468000													31	88					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42874365	42874365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42874365C>T	ENST00000334370.4	+	38	7293	c.6658C>T	c.(6658-6660)Ccg>Tcg	p.P2220S	MEGF8_ENST00000378073.4_5'UTR|MEGF8_ENST00000251268.6_Missense_Mutation_p.P2287S	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2287						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GCAGTGCCTCCCGCTGTTTGT	0.612000													17	49					0	0	1	0	0
EXOC3L2	90332	broad.mit.edu	37	19	45728116	45728116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45728116C>T	ENST00000413988.1	-	6	500	c.460G>A	c.(460-462)Gaa>Aaa	p.E154K	EXOC3L2_ENST00000252482.3_Missense_Mutation_p.E154K	NM_138568.3	NP_612635.3	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	154										endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		GCAGATGCTTCCCGGGCCGGC	0.652000													7	17					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104176568	104176568	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104176568G>T	ENST00000020673.5	-	2	754	c.228C>A	c.(226-228)ccC>ccA	p.P76P	PSD_ENST00000492902.2_5'UTR|PSD_ENST00000406432.1_Silent_p.P76P	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	76	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GAGCAACACGGGGTGAGGGGG	0.672000													31	71					4.02929e-09	4.04425e-09	1	1	0
DNAH7	56171	broad.mit.edu	37	2	196651856	196651856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196651856G>A	ENST00000312428.6	-	58	10856	c.10756C>T	c.(10756-10758)Cat>Tat	p.H3586Y	DNAH7_ENST00000409063.1_Missense_Mutation_p.H69Y	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3586	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACCAAAGCATGAAAGAAACAC	0.388000													21	92					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6862869	6862869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6862869G>A	ENST00000307659.5	+	7	1215	c.760G>A	c.(760-762)Gag>Aag	p.E254K	KIAA0232_ENST00000425103.1_Missense_Mutation_p.E254K	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	254							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						AAGCAAAAACGAGAAGGAAAA	0.428000													12	72					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181701992	181701992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181701992C>T	ENST00000526775.1	+	19	2878	c.2713C>T	c.(2713-2715)Cgc>Tgc	p.R905C	CACNA1E_ENST00000367570.1_Missense_Mutation_p.R924C|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R531C|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R905C|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R875C|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R856C|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R924C	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	924					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CAGCCGGCATCGCCGCGTCAG	0.647000													34	116					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27517296	27517296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27517296G>A	ENST00000356183.4	-	10	1709	c.1694C>T	c.(1693-1695)tCc>tTc	p.S565F	GTF3C1_ENST00000561623.1_Missense_Mutation_p.S565F	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	565						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGAGACAAAGGACACGTTGGG	0.587000													48	82					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6501056	6501056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6501056G>A	ENST00000377828.1	+	5	1089	c.921G>A	c.(919-921)acG>acA	p.T307T		NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	307					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		ACGGGTACACGGCCGCCGACC	0.697000													4	19					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129276034	129276034	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129276034C>T	ENST00000324093.4	-	34	5656	c.5478G>A	c.(5476-5478)aaG>aaA	p.K1826K	PLXND1_ENST00000393239.1_3'UTR|PLXND1_ENST00000504689.1_5'UTR	NM_015103.2	NP_055918.2	Q9Y4D7	PLXD1_HUMAN	plexin D1	1826					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CAGGAATCTCCTTGGCGTAGA	0.557000													25	74					0	0	1	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64698931	64698931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64698931C>T	ENST00000164133.2	+	9	1537	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_006244.3	NP_006235.1	Q15173	2A5B_HUMAN	protein phosphatase 2, regulatory subunit B', beta	305					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)	21						TGGTGCAGTTCCTGGAGAAGG	0.602000													14	26					0	0	1	0	0
RAB6C	84084	broad.mit.edu	37	2	130738443	130738443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130738443C>T	ENST00000410061.2	+	1	1209	c.755C>T	c.(754-756)tCg>tTg	p.S252L		NM_032144.2	NP_115520.2	Q9H0N0	RAB6C_HUMAN	RAB6C, member RAS oncogene family	252					protein transport|response to drug|small GTPase mediated signal transduction		GTP binding|GTPase activity			large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	5	Colorectal(110;0.1)					CTGCCTGTCTCGTGGAGGTGA	0.373000													31	84					0	0	1	0	0
RSPH4A	345895	broad.mit.edu	37	6	116938431	116938431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116938431G>A	ENST00000229554.5	+	1	782	c.645G>A	c.(643-645)aaG>aaA	p.K215K	RSPH4A_ENST00000368581.4_Silent_p.K215K|RSPH4A_ENST00000368580.4_Silent_p.K215K	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	215					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						AGAATGCTAAGGCTTACCTGC	0.483000									Kartagener syndrome				20	82					0	0	1	0	0
RASL10B	91608	broad.mit.edu	37	17	34068188	34068188	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34068188C>T	ENST00000268864.3	+	4	853	c.476C>T	c.(475-477)tCg>tTg	p.S159L		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	159	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTGGAATGCTCGGCCAAGTAC	0.647000													17	26					0	0	1	0	0
HTR3E	285242	broad.mit.edu	37	3	183822058	183822058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183822058C>T	ENST00000415389.2	+	4	834	c.368C>T	c.(367-369)cCa>cTa	p.P123L	HTR3E_ENST00000440596.2_Missense_Mutation_p.P123L|HTR3E_ENST00000425359.2_Missense_Mutation_p.P108L|HTR3E_ENST00000436361.2_Missense_Mutation_p.P123L|HTR3E-AS1_ENST00000431427.1_RNA|HTR3E_ENST00000335304.2_Missense_Mutation_p.P138L	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	123						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CTGTGGCTCCCAGACATTTTC	0.517000													8	20					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23810624	23810624	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23810624G>A	ENST00000354639.3	+	14	2109	c.1644_splice	c.e14-1	p.D549_splice	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Splice_Site_p.D572_splice|STK31_ENST00000355870.3_Splice_Site_p.D572_splice|STK31_ENST00000428484.1_Splice_Site_p.D549_splice	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	572							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTTCATTTAGGATCAAGGTGA	0.338000													41	88					0	0	1	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6890533	6890533	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6890533C>T	ENST00000419673.2	+	13	1579	c.1362C>T	c.(1360-1362)ctC>ctT	p.L454L	ARHGAP28_ENST00000262227.3_Silent_p.L561L|ARHGAP28_ENST00000532996.1_Silent_p.L436L|ARHGAP28_ENST00000314319.3_Silent_p.L454L|ARHGAP28_ENST00000383472.4_Silent_p.L613L|ARHGAP28_ENST00000418986.1_Silent_p.L454L|ARHGAP28_ENST00000400091.2_Silent_p.L613L|ARHGAP28_ENST00000531294.1_Silent_p.L449L	NM_001010000.2	NP_001010000.1	B4DXL2	B4DXL2_HUMAN	Rho GTPase activating protein 28	436					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				GGAAGACCCTCGAGCGGGAGG	0.473000													9	26					0	0	1	0	0
WFDC3	140686	broad.mit.edu	37	20	44416581	44416581	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44416581G>A	ENST00000243938.4	-	4	335	c.252C>T	c.(250-252)tcC>tcT	p.S84S	WFDC3_ENST00000481847.1_5'UTR|WFDC3_ENST00000372630.2_Intron|WFDC3_ENST00000372632.2_Intron	NM_080614.1	NP_542181.1	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3	84	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity	p.S84>?(1)		endometrium(1)|large_intestine(3)|prostate(1)	5		Myeloproliferative disorder(115;0.0122)				TTTTCAAACAGGATTGTTTCC	0.463000													26	64					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342696	29342696	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29342696G>A	ENST00000396806.3	-	1	372	c.369C>T	c.(367-369)gcC>gcT	p.A123A	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						GATTGCAGATGGCAACAAAAC	0.488000													10	56					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89653510	89653510	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89653510C>T	ENST00000268720.5	+	11	1282	c.1152_splice	c.e11+1	p.T384_splice	CPNE7_ENST00000319518.8_Splice_Site_p.T309_splice	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	384	VWFA.				lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		TCCACTTCACCGTGAGTCCAT	0.721000													4	2					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50903491	50903491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50903491G>A	ENST00000380817.2	-	12	1454	c.1271C>T	c.(1270-1272)gCc>gTc	p.A424V	SBF1_ENST00000390679.3_Missense_Mutation_p.A424V|SBF1_ENST00000348911.6_Missense_Mutation_p.A425V	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	424	dDENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GCCAGCAAAGGCCATGCCCTC	0.647000													15	27					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100210086	100210086	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:100210086G>A	ENST00000317233.4	-	14	2272	c.2037C>T	c.(2035-2037)tcC>tcT	p.S679S	AFF3_ENST00000356421.2_Silent_p.S704S|AFF3_ENST00000409236.1_Silent_p.S679S|AFF3_ENST00000409579.1_Silent_p.S704S	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	679	Poly-Ser.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.S704>?(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						ACTCCAGGTCGGAGTCCGAGG	0.612000													32	109					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59899274	59899274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:59899274G>A	ENST00000265036.5	-	9	1253	c.1186C>T	c.(1186-1188)Cct>Tct	p.P396S	DEPDC1B_ENST00000453022.2_Missense_Mutation_p.P396S|DEPDC1B_ENST00000545085.1_Missense_Mutation_p.P369S	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	396					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity	p.P396S(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				AAGGCCAAAGGGACTTTCAGA	0.418000													26	67					0	0	1	0	0
GYPA	2993	broad.mit.edu	37	4	145038021	145038021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:145038021G>A	ENST00000360771.4	-	5	458	c.343C>T	c.(343-345)Cgc>Tgc	p.R115C	GYPB_ENST00000283126.7_Intron|GYPA_ENST00000324022.10_Missense_Mutation_p.R82C|RP11-673E1.4_ENST00000506982.1_RNA|GYPA_ENST00000504786.1_Missense_Mutation_p.R83C|GYPA_ENST00000512789.1_Missense_Mutation_p.R50C|GYPA_ENST00000535709.1_Missense_Mutation_p.R89C|GYPA_ENST00000512064.1_Missense_Mutation_p.R102C|GYPA_ENST00000503627.1_Missense_Mutation_p.R70C	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	115					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					ATCAGTCGGCGAATACCGTAA	0.368000													41	97					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15580660	15580660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15580660G>A	ENST00000292609.4	-	4	1553	c.1424C>T	c.(1423-1425)tCc>tTc	p.S475F	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.S475F			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	475					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GAAGCCCCGGGAGTTGTGGCC	0.706000													4	11					0	0	1	0	0
SWI5	375757	broad.mit.edu	37	9	131038524	131038524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131038524C>T	ENST00000320188.4	+	1	100	c.100C>T	c.(100-102)Cct>Tct	p.P34S		NM_001040011.1	NP_001035100.1	Q1ZZU3	SWI5_HUMAN	SWI5 recombination repair homolog (yeast)	34					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding										GGCCGGCTTTCCTTGGGTGCG	0.682000													12	15					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4968065	4968065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:4968065G>A	ENST00000333703.4	+	5	2926	c.2413G>A	c.(2413-2415)Gaa>Aaa	p.E805K	PCDH11Y_ENST00000362095.5_Missense_Mutation_p.E816K|PCDH11Y_ENST00000215473.6_Missense_Mutation_p.E816K	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	816	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						ACTGATTAATGAACTGGTGCG	0.438000													21	85					0	0	1	0	0
UVRAG	7405	broad.mit.edu	37	11	75852018	75852018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75852018C>T	ENST00000356136.3	+	15	1902	c.1661C>T	c.(1660-1662)tCc>tTc	p.S554F	UVRAG_ENST00000539288.1_Missense_Mutation_p.S182F|UVRAG_ENST00000533454.1_Missense_Mutation_p.S182F|UVRAG_ENST00000538870.1_Missense_Mutation_p.S110F|UVRAG_ENST00000531818.1_Missense_Mutation_p.S182F|UVRAG_ENST00000528420.1_Missense_Mutation_p.S453F|UVRAG_ENST00000532130.1_Missense_Mutation_p.S182F	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	554					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						TTGGATACCTCCTTGGACTTC	0.502000													16	53					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96702033	96702033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96702033G>A	ENST00000260682.6	+	3	428	c.416G>A	c.(415-417)aGg>aAg	p.R139K	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	139					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	ATGGGGAAGAGGAGCATTGAG	0.498000													50	105					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55955503	55955503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55955503C>T	ENST00000373965.2	-	11	1639	c.1245G>A	c.(1243-1245)tcG>tcA	p.S415S	PCDH15_ENST00000395445.1_Silent_p.S415S|PCDH15_ENST00000409834.1_Silent_p.S19S|PCDH15_ENST00000437009.1_Silent_p.S415S|PCDH15_ENST00000361849.3_Silent_p.S415S|PCDH15_ENST00000373957.3_Silent_p.S393S|PCDH15_ENST00000395433.1_Silent_p.S393S|PCDH15_ENST00000395432.2_Silent_p.S378S|PCDH15_ENST00000395440.1_Silent_p.S415S|PCDH15_ENST00000395446.1_Silent_p.S415S|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373955.1_Silent_p.S415S|PCDH15_ENST00000414778.1_Silent_p.S420S|PCDH15_ENST00000395430.1_Silent_p.S415S|PCDH15_ENST00000320301.6_Silent_p.S415S|PCDH15_ENST00000395438.1_Silent_p.S415S	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	415	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGAGACTGTCCGAAATGGTTG	0.368000										HNSCC(58;0.16)			31	77					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29498068	29498068	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29498068C>T	ENST00000389048.3	-	11	2844	c.1938G>A	c.(1936-1938)caG>caA	p.Q646Q	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	646					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTGCTGTATTCTGCAGGATCT	0.488000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				20	64					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466993	56466993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56466993C>T	ENST00000291971.3	+	3	1640	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F	NLRP8_ENST00000590542.1_Silent_p.F523F	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	523	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTCTCTGTTTCCCACAAAGAC	0.443000													61	176					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57587458	57587458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57587458C>T	ENST00000243077.3	+	47	8260	c.7794C>T	c.(7792-7794)atC>atT	p.I2598I		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2598	LDL-receptor class A 12.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTGACGAGATCCCTTGCAACA	0.612000													10	52					0	0	1	0	0
IL15RA	3601	broad.mit.edu	37	10	6008124	6008124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6008124G>A	ENST00000525219.2	-	2	453	c.159C>T	c.(157-159)ccC>ccT	p.P53P	IL15RA_ENST00000379971.1_Intron|IL15RA_ENST00000530685.1_Silent_p.P89P|IL15RA_ENST00000397250.2_Intron|IL15RA_ENST00000397248.2_Silent_p.P53P|IL15RA_ENST00000379977.3_Silent_p.P89P|IL15RA_ENST00000534292.1_5'UTR|IL15RA_ENST00000397251.3_Intron|IL15RA_ENST00000397255.3_Silent_p.P89P|IL15RA_ENST00000528354.1_Silent_p.P89P	NM_001243539.1	NP_001230468.1	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha	89	Sushi.				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5						ATTTGAGACTGGGGGTTGTCC	0.572000													8	36					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151337180	151337180	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151337180C>T	ENST00000426705.2	-	12	1528	c.1382_splice	c.e12-1	p.E462_splice	SELENBP1_ENST00000447402.3_Splice_Site_p.E358_splice|SELENBP1_ENST00000435071.1_Splice_Site_p.E356_splice|SELENBP1_ENST00000368868.5_Splice_Site_p.E420_splice	NM_001258289.1	NP_001245218.1	Q13228	SBP1_HUMAN	selenium binding protein 1	420					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACAGAGCCTTCCCTGGTGGAA	0.557000													16	156					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77389848	77389848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77389848C>T	ENST00000282849.5	-	9	1867	c.1449G>A	c.(1447-1449)aaG>aaA	p.K483K		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	483	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGAGGAATTTCTTGAGATACT	0.478000													10	105					0	0	1	0	0
SPNS2	124976	broad.mit.edu	37	17	4437103	4437103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4437103G>A	ENST00000329078.3	+	9	1509	c.1299G>A	c.(1297-1299)gaG>gaA	p.E433E		NM_001124758.1	NP_001118230.1	Q8IVW8	SPNS2_HUMAN	spinster homolog 2 (Drosophila)	433					lipid transport|transmembrane transport	integral to membrane				large_intestine(3)|lung(1)|prostate(1)|skin(1)	6						TCGTCGGGGAGACGCTGCTGT	0.592000													8	46					0	0	1	0	0
TMEM180	79847	broad.mit.edu	37	10	104235581	104235581	+	Missense_Mutation	SNP	A	A	C	rs144994591		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104235581A>C	ENST00000238936.4	+	10	1631	c.1394A>C	c.(1393-1395)cAg>cCg	p.Q465P	TMEM180_ENST00000366277.2_Missense_Mutation_p.Q194P	NM_024789.3	NP_079065.2	Q14CX5	TM180_HUMAN	transmembrane protein 180	465						integral to membrane				breast(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|skin(1)	13		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ACGCTCCGCCAGGGCTGCTTC	0.652000													14	37					0	0	1	0	0
HCN3	57657	broad.mit.edu	37	1	155253804	155253804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155253804C>T	ENST00000368358.3	+	3	756	c.748C>T	c.(748-750)Cgc>Tgc	p.R250C	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	250						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGCTGTGGTTCGCATCTTCAA	0.572000													31	88					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064557	7064557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7064557G>A	ENST00000299481.4	+	4	1646	c.1300G>A	c.(1300-1302)Gga>Aga	p.G434R		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	434	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CGCTGCCAAAGGAATATGGAC	0.428000													57	137					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3440797	3440797	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3440797G>A	ENST00000356575.4	-	5	721	c.495C>T	c.(493-495)tgC>tgT	p.C165C	MEGF6_ENST00000294599.4_Silent_p.C60C	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	165	EGF-like 2; calcium-binding (Potential).					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TGTGGGTTCGGCATTCGTCCA	0.647000													18	49					0	0	1	0	0
GOT2	2806	broad.mit.edu	37	16	58750625	58750625	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58750625G>A	ENST00000245206.5	-	7	923	c.795C>T	c.(793-795)atC>atT	p.I265I	GOT2_ENST00000434819.2_Silent_p.I222I|GOT2_ENST00000564400.1_Intron	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	265					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TGCCCTGTTCGATGAAGTGGC	0.488000													11	39					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168212924	168212924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168212924G>A	ENST00000519560.1	-	12	1558	c.1139C>T	c.(1138-1140)tCc>tTc	p.S380F	SLIT3_ENST00000332966.8_Missense_Mutation_p.S380F|SLIT3_ENST00000404867.3_Missense_Mutation_p.S380F	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	380					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGCTGTAGGGACACCAGCCC	0.502000													20	52					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48220034	48220034	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48220034C>T	ENST00000263277.3	+	2	416	c.165C>T	c.(163-165)ttC>ttT	p.F55F	EHD2_ENST00000538399.1_Intron|CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	55					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		ACGCAGACTTCGACGGCAAGC	0.677000													13	25					0	0	1	0	0
TMEM57	55219	broad.mit.edu	37	1	25824819	25824819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:25824819C>T	ENST00000374343.4	+	11	2036	c.1857C>T	c.(1855-1857)gcC>gcT	p.A619A	TMEM57_ENST00000399766.3_Silent_p.A392A|TMEM57_ENST00000399763.3_Silent_p.A261A	NM_018202.4	NP_060672.2	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	619						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part		p.A619A(1)		breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		AAGTCATGGCCGTCATGCCCA	0.502000													38	93					0	0	1	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209950791	209950791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209950791G>A	ENST00000367024.1	+	12	1664	c.1148G>A	c.(1147-1149)gGg>gAg	p.G383E	TRAF3IP3_ENST00000477431.1_Missense_Mutation_p.G119E|TRAF3IP3_ENST00000367026.3_Missense_Mutation_p.G363E|TRAF3IP3_ENST00000400959.3_Missense_Mutation_p.G363E|TRAF3IP3_ENST00000367023.1_Missense_Mutation_p.G119E|TRAF3IP3_ENST00000367025.3_Missense_Mutation_p.G383E|TRAF3IP3_ENST00000010338.4_Missense_Mutation_p.G363E			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	383						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		TGCCTGCAAGGGGACAGAGAC	0.522000													14	48					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156814893	156814893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156814893G>A	ENST00000368195.3	-	12	2808	c.2412C>T	c.(2410-2412)ttC>ttT	p.F804F	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	804					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCGCAAAGACGAAGGTGGCGG	0.632000													3	1					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86416200	86416200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86416200G>A	ENST00000361669.2	+	3	2191	c.1092G>A	c.(1090-1092)caG>caA	p.Q364Q	GRM3_ENST00000394720.2_Silent_p.Q362Q|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Silent_p.Q364Q|GRM3_ENST00000536043.1_Silent_p.Q236Q	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	364					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCAGCCTCCAGAACAAACGCA	0.567000													20	43					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30701523	30701523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30701523C>T	ENST00000256246.2	-	1	5085	c.5011G>A	c.(5011-5013)Gac>Aac	p.D1671N		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1671										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGGTTTTGGTCTACCAACAGT	0.338000													23	80					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819464	159819464	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159819464C>T	ENST00000497452.1	-	0	517																											AGAGAGAGGACTCTGGAGATG	0.463000													81	204					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75929447	75929447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:75929447G>A	ENST00000321027.3	-	3	630	c.497C>T	c.(496-498)tCc>tTc	p.S166F	GCFC2_ENST00000470503.1_Missense_Mutation_p.S166F|GCFC2_ENST00000541687.1_Missense_Mutation_p.S166F|GCFC2_ENST00000409857.3_Missense_Mutation_p.S166F	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	166					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										ACCAGAGATGGAGGAGGTATG	0.448000													57	121					0	0	1	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20470032	20470032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20470032G>A	ENST00000375102.3	+	3	365	c.263G>A	c.(262-264)gGt>gAt	p.G88D		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	45					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GTGGGCTACGGTTGCTACTGT	0.637000													16	73					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141457966	141457966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141457966G>A	ENST00000389484.3	-	41	7623	c.6652C>T	c.(6652-6654)Cca>Tca	p.P2218S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2218					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAATAACGTGGATTCTCATAT	0.333000										TSP Lung(27;0.18)			20	131					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33590868	33590868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33590868C>T	ENST00000380099.3	+	1	298	c.290C>T	c.(289-291)cCc>cTc	p.P97L	KL_ENST00000426690.2_Intron|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	97	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACCCACCACCCCCTGGCACCC	0.721000													5	17					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767873	105767873	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:105767873G>A	ENST00000374798.3	+	5	1030	c.960G>A	c.(958-960)aaG>aaA	p.K320K	CYLC2_ENST00000487798.1_Silent_p.K320K	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	320	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				aggatgcaaagaaaaatgcta	0.398000													7	21					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141059162	141059162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141059162G>A	ENST00000239440.4	-	4	713	c.648C>T	c.(646-648)gcC>gcT	p.A216A	ARAP3_ENST00000508305.1_Silent_p.A138A	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	216					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TTCTGTCGGGGGCTCCTGGAG	0.572000													15	61					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16306646	16306646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:16306646C>T	ENST00000244769.4	-	9	3298	c.2362G>A	c.(2362-2364)Gaa>Aaa	p.E788K	ATXN1_ENST00000436367.1_Missense_Mutation_p.E788K	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	788	Interaction with USP7.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				AAAGGTGGTTCGTCTTCTGAC	0.547000													35	79					0	0	1	0	0
CBL	867	broad.mit.edu	37	11	119156009	119156009	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119156009C>T	ENST00000264033.4	+	11	2050	c.1674C>T	c.(1672-1674)tcC>tcT	p.S558S		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	558	Pro-rich.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		GAGCAGAATCCCGACCTCAAA	0.577000			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies		OREG0021401	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	72					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108051462	108051462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108051462C>T	ENST00000280758.5	+	17	3810	c.3282C>T	c.(3280-3282)atC>atT	p.I1094I	BTBD11_ENST00000494235.2_Silent_p.I173I|BTBD11_ENST00000420571.2_Silent_p.I975I|BTBD11_ENST00000357167.4_Silent_p.I631I	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	1094						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TTCAGTCCATCCACTTGTCGT	0.507000													24	56					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40030920	40030920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40030920G>A	ENST00000372857.3	-	8	1895	c.1103C>T	c.(1102-1104)gCc>gTc	p.A368V	PABPC4_ENST00000372862.3_Missense_Mutation_p.A368V|PABPC4_ENST00000372856.3_Missense_Mutation_p.A368V|PABPC4_ENST00000372858.3_Missense_Mutation_p.A368V|RP11-69E11.8_ENST00000415255.1_RNA	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	368	RRM 4.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTTCCTCTGGGCCAGGGCAAC	0.498000													5	50					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110864522	110864522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110864522G>A	ENST00000265171.5	+	3	885	c.440G>A	c.(439-441)gGa>gAa	p.G147E	EGF_ENST00000502723.1_3'UTR|EGF_ENST00000509793.1_Missense_Mutation_p.G147E|EGF_ENST00000503392.1_Missense_Mutation_p.G147E	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	147					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GATATGAAAGGAAATAATTCC	0.308000													35	76					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159170685	159170685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159170685G>A	ENST00000368125.4	+	9	1327	c.1170G>A	c.(1168-1170)ggG>ggA	p.G390G	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000497636.1_3'UTR|CADM3_ENST00000368124.4_Silent_p.G424G	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	390					adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					AGTCAGGAGGGGACGACAAGA	0.612000													17	89					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102212	168102212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168102212G>A	ENST00000409195.1	+	9	4399	c.4310G>A	c.(4309-4311)cGa>cAa	p.R1437Q	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R1437Q|XIRP2_ENST00000409273.1_Missense_Mutation_p.R1215Q|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1262					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AACTATATACGAACAGTAAGT	0.338000													13	53					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584330	30584330	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30584330C>T	ENST00000217299.3	+	3	984	c.810C>T	c.(808-810)ctC>ctT	p.L270L		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	270						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CCGCCTCCCTCGTGTCTCTGG	0.711000													7	16					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176813028	176813028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176813028C>T	ENST00000324417.5	+	3	241	c.150C>T	c.(148-150)ccC>ccT	p.P50P	SLC34A1_ENST00000512593.1_Silent_p.P50P	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	50					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGCCTTCCCCAGCCTGGGCC	0.682000													36	67					0	0	1	0	0
DNPEP	23549	broad.mit.edu	37	2	220239650	220239650	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220239650G>A	ENST00000273075.4	-	14	1554	c.1334C>T	c.(1333-1335)cCc>cTc	p.P445L	DNPEP_ENST00000373972.1_Missense_Mutation_p.P370L|DNPEP_ENST00000490371.1_5'UTR|DNPEP_ENST00000523282.1_Missense_Mutation_p.P453L	NM_012100.2	NP_036232.2	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	435					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	GGCCAGTTGGGGGCTGCCTAA	0.607000													20	54					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284211	159284211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159284211G>A	ENST00000332217.5	-	1	238	c.239C>T	c.(238-240)cCc>cTc	p.P80L		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					AAGCATATGGGGAATGATGGC	0.493000													34	79					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48654501	48654501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48654501G>A	ENST00000263274.7	-	7	981	c.562C>T	c.(562-564)Cta>Tta	p.L188L	LIG1_ENST00000599165.1_5'UTR|LIG1_ENST00000536218.1_Intron|LIG1_ENST00000427526.2_Silent_p.L157L	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	188					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GAGGTCTTTAGGGGCTTGGGA	0.552000								Nucleotide excision repair (NER)					40	158					0	0	1	0	0
ART1	417	broad.mit.edu	37	11	3682615	3682615	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3682615G>A	ENST00000250693.1	+	4	959	c.858G>A	c.(856-858)aaG>aaA	p.K286K		NM_004314.2	NP_004305.2	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1	286					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|skin(1)	8		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	AGAAGTGCAAGTCTGGGCCTT	0.532000													26	57					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144875014	144875014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144875014G>A	ENST00000356994.2	-	30	4047	c.4041C>T	c.(4039-4041)gcC>gcT	p.A1347A	SCRIB_ENST00000377533.3_Silent_p.A1266A|SCRIB_ENST00000546337.1_5'UTR|SCRIB_ENST00000320476.3_Silent_p.A1347A	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	1347	Pro-rich.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GCTCCGGGGAGGCTGCAGGCC	0.711000													10	18					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168105525	168105525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168105525G>A	ENST00000409195.1	+	9	7712	c.7623G>A	c.(7621-7623)aaG>aaA	p.K2541K	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Silent_p.K2541K|XIRP2_ENST00000409273.1_Silent_p.K2319K|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2366					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAAAATTTAAGACACCTTTAA	0.318000													43	125					0	0	1	0	0
SRD5A2	6716	broad.mit.edu	37	2	31805774	31805774	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31805774C>T	ENST00000405650.1	-	0	362							P31213	S5A2_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)						androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity					Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GGCGAGGATCCCCGCGGGCAC	0.667000													5	17					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172766859	172766859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172766859C>T	ENST00000351008.3	-	3	821	c.638G>A	c.(637-639)gGa>gAa	p.G213E		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	213					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AAATGGTTCTCCCAGAACTGC	0.348000													12	38					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1325382	1325382	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1325382G>A	ENST00000381567.3	-	3	292	c.293C>T	c.(292-294)tCc>tTc	p.S98F	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Missense_Mutation_p.S98F	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	98						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				ATTCCTGATGGAGAAATAGAG	0.512000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								20	98					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813932	106813932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106813932G>A	ENST00000407775.2	+	8	1872	c.1622G>A	c.(1621-1623)aGc>aAc	p.S541N	ZFPM2_ENST00000520492.1_Missense_Mutation_p.S409N|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S272N|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S409N|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	541					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GTCATTTACAGCCCTTTGATG	0.453000													53	95					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21712328	21712328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21712328G>A	ENST00000388958.3	+	10	961	c.960G>A	c.(958-960)agG>agA	p.R320R	OTOA_ENST00000388956.4_Silent_p.R241R|OTOA_ENST00000286149.4_Silent_p.R320R	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	320					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		TTAACATGAGGAATACCTCCA	0.522000													17	46					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92730808	92730808	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92730808C>T	ENST00000379958.2	-	3	4872	c.4603G>A	c.(4603-4605)Gaa>Aaa	p.E1535K		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1535						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CAATTGTTTTCAGCTCGACCT	0.373000													19	45					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39965022	39965022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39965022C>T	ENST00000599117.1	+	28	3167	c.2800C>T	c.(2800-2802)Ccg>Tcg	p.P934S	SUPT5H_ENST00000598725.1_Missense_Mutation_p.P934S|SUPT5H_ENST00000402194.2_Missense_Mutation_p.P930S|SUPT5H_ENST00000359191.6_Missense_Mutation_p.P930S|SUPT5H_ENST00000432763.2_Missense_Mutation_p.P934S			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	934	10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y, motif CTR2.|Pro-rich.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCACCCTACACCGTCGCCCAT	0.632000											OREG0025462	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	38					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166976311	166976311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:166976311C>T	ENST00000061240.2	+	13	2255	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	TLL1_ENST00000507499.1_Silent_p.F559F	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	536	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TAGGGCGTTTCTGTGGTTATG	0.398000													27	69					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222217	140222217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140222217C>T	ENST00000531613.1	+	1	1311	c.1311C>T	c.(1309-1311)gcC>gcT	p.A437A	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Silent_p.A437A|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGTGGGCCACCGCCAGCT	0.657000													33	32					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82319705	82319705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:82319705C>T	ENST00000376552.2	+	9	1635	c.617C>T	c.(616-618)tCa>tTa	p.S206L	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376520.4_Intron|TLE4_ENST00000376537.4_Missense_Mutation_p.S206L|TLE4_ENST00000265284.6_Missense_Mutation_p.S181L|TLE4_ENST00000376544.3_Intron	NM_007005.3	NP_008936.2	O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CAGAGCTCTTCAGTATCCCCA	0.403000													72	166					0	0	1	0	0
KLRD1	3824	broad.mit.edu	37	12	10462275	10462275	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10462275G>A	ENST00000381908.3	+	3	411	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K	KLRD1_ENST00000538997.1_3'UTR|KLRD1_ENST00000381907.4_Missense_Mutation_p.E51K|KLRD1_ENST00000350274.5_Missense_Mutation_p.E20K|KLRD1_ENST00000336164.4_Missense_Mutation_p.E51K|KLRD1_ENST00000543777.1_Intron|KLRD1_ENST00000543420.1_Missense_Mutation_p.E51K			Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D, member 1	51					cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	10						ACCCAACATAGAACTCCAGAA	0.333000													5	39					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240374523	240374523	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240374523G>A	ENST00000319653.9	+	6	4283	c.4053G>A	c.(4051-4053)acG>acA	p.T1351T		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1351	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCTCAAAGACGAAGGCTAAAC	0.338000													40	109					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105842748	105842748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:105842748G>A	ENST00000282499.5	+	15	2848	c.2402G>A	c.(2401-2403)gGa>gAa	p.G801E	GRIA4_ENST00000530497.1_Missense_Mutation_p.G801E|GRIA4_ENST00000393127.2_Intron|GRIA4_ENST00000525187.1_Intron|GRIA4_ENST00000533094.1_Intron	NM_000829.3	NP_000820.3	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	801					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	AAGGACTCTGGAAGCAAGGTC	0.458000													20	57					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23177458	23177458	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:23177458G>A	ENST00000389131.3	-	8	1779	c.1410C>T	c.(1408-1410)atC>atT	p.I470I		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	470	SRCR 4.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TGGCCTCCACGATGCCCCAGT	0.657000													27	59					0	0	1	0	0
FLVCR1	28982	broad.mit.edu	37	1	213046096	213046096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:213046096C>T	ENST00000366971.4	+	3	1158	c.960C>T	c.(958-960)tcC>tcT	p.S320S		NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	320					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		AAGAGTACTCCTATAAGAAAT	0.383000													14	54					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141044607	141044607	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141044607C>T	ENST00000239440.4	-	19	2747	c.2682G>A	c.(2680-2682)tgG>tgA	p.W894*	ARAP3_ENST00000512390.1_5'UTR|ARAP3_ENST00000513878.1_Nonsense_Mutation_p.W556*|ARAP3_ENST00000508305.1_Nonsense_Mutation_p.W796*	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	894					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding	p.W894*(1)		NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TGGCTGCGTTCCATGCCGTGA	0.652000											OREG0016871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	22					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1427378	1427378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:1427378G>A	ENST00000446702.2	+	20	3228	c.2601G>A	c.(2599-2601)acG>acA	p.T867T	CNTN6_ENST00000539053.1_Silent_p.T795T|CNTN6_ENST00000350110.2_Silent_p.T867T			Q9UQ52	CNTN6_HUMAN	contactin 6	867	Fibronectin type-III 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAAACATCACGGGGCTGAAAG	0.428000													50	128					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150432701	150432701	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150432701C>T	ENST00000401000.4	+	8	1306	c.1241C>T	c.(1240-1242)tCc>tTc	p.S414F	RPRD2_ENST00000539519.1_Missense_Mutation_p.S414F|RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.S440F			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	440							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CTTTCCCCTTCCCCAGCATTG	0.448000													10	24					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150721387	150721387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150721387C>T	ENST00000605938.1	-	1	199	c.124G>A	c.(124-126)Gga>Aga	p.G42R	ATG9B_ENST00000377974.2_Missense_Mutation_p.G42R|ATG9B_ENST00000444312.1_5'UTR|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000605952.1_Missense_Mutation_p.G42R	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	42	Pro-rich.				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCCAGGTCCCCGGCATGAA	0.672000													4	9					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117552767	117552767	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117552767C>T	ENST00000374045.4	-	4	834	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	TNFSF15_ENST00000374044.1_Missense_Mutation_p.E164K	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	241					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						GTTTTATCTTCTTTTGTGTAA	0.428000													33	121					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678098	25678098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25678098G>A	ENST00000382051.3	+	13	1850	c.1800G>A	c.(1798-1800)ctG>ctA	p.L600L	SLC34A2_ENST00000503434.1_Silent_p.L599L|SLC34A2_ENST00000504570.1_Silent_p.L599L	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	600					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TGCGCTCGCTGAAGCCCTGGG	0.642000			T	ROS1	NSCLC								30	95					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142021257	142021257	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142021257C>T	ENST00000390381.3	+	0	546																											AAGGAAACTTCCCTGGTCGAT	0.527000													21	37					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9084500	9084500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9084500C>T	ENST00000397910.4	-	1	7518	c.7315G>A	c.(7315-7317)Ggg>Agg	p.G2439R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2439	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGGAGCCCCCATCAAGAGAA	0.502000													4	42					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20623038	20623038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20623038C>T	ENST00000525748.1	+	2	640	c.367C>T	c.(367-369)Cct>Tct	p.P123S		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	123					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CTGTAAGATCCCTTTTCTGCG	0.672000													7	18					0	0	1	0	0
ZBED1	9189	broad.mit.edu	37	X	2408546	2408546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:2408546G>A	ENST00000381223.4	-	2	418	c.215C>T	c.(214-216)cCc>cTc	p.P72L	ZBED1_ENST00000381222.2_Missense_Mutation_p.P72L|ZBED1_ENST00000381218.3_Missense_Mutation_p.P72L|DHRSX_ENST00000334651.5_Intron	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	72						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GAATTCCTCGGGGTGGTTCTT	0.582000													30	96					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208804	58208804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58208804C>T	ENST00000377918.3	+	1	2150	c.2124C>T	c.(2122-2124)ctC>ctT	p.L708L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	708					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGCTGCCGCTCATCGTGACTC	0.592000													23	58					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126137038	126137038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:126137038C>T	ENST00000299308.3	+	8	1959	c.1951C>T	c.(1951-1953)Ctg>Ttg	p.L651L	TMEM132B_ENST00000535886.1_Silent_p.L163L	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	651						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGTGATTGTCCTGGATGACCG	0.582000													8	40					0	0	1	0	0
OR51M1	390059	broad.mit.edu	37	11	5411015	5411015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5411015G>A	ENST00000328611.3	+	1	409	c.387G>A	c.(385-387)atG>atA	p.M129I	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004756.2	NP_001004756.2	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M, member 1	129						integral to membrane	olfactory receptor activity			NS(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|upper_aerodigestive_tract(1)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCTCCTCATGATGTCCTTTG	0.488000													75	234					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30495438	30495438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30495438G>A	ENST00000356798.6	+	9	1040	c.860G>A	c.(859-861)gGa>gAa	p.G287E	ITGAL_ENST00000454514.2_3'UTR|ITGAL_ENST00000358164.5_Missense_Mutation_p.G204E|ITGAL_ENST00000433423.2_Intron|RP11-297C4.2_ENST00000569459.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	287	VWFA.				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TCACAGATTGGAAAGCATTTT	0.483000													20	170					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8698473	8698473	+	Silent	SNP	C	C	T	rs145869401	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:8698473C>T	ENST00000378641.3	+	14	1966	c.1491C>T	c.(1489-1491)ttC>ttT	p.F497F	PLCB1_ENST00000338037.6_Silent_p.F497F|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Silent_p.F497F	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	497					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CCAGCATGTTCGAGCCCTCAT	0.522000													13	43					0	0	1	0	0
WIBG	84305	broad.mit.edu	37	12	56295662	56295662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56295662G>A	ENST00000408946.2	-	3	760	c.609C>T	c.(607-609)ggC>ggT	p.G203G	WIBG_ENST00000302533.6_5'UTR|WIBG_ENST00000398213.4_Silent_p.G202G	NM_032345.2	NP_115721.1	Q9BRP8	WIBG_HUMAN	within bgcn homolog (Drosophila)	203	eIF2A-like.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|exon-exon junction complex|nucleolus|nucleoplasm	protein binding|ribosome binding|RNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						GGCCTCAGAGGCCTAACTCCA	0.577000													81	263					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12656327	12656327	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12656327G>A	ENST00000425538.1	+	10	1922	c.1722G>A	c.(1720-1722)gaG>gaA	p.E574E	MYOCD_ENST00000395988.1_Silent_p.E478E|MYOCD_ENST00000343344.4_Silent_p.E574E	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	574					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGCAGGAAGAGGCTGTCTCCA	0.532000													28	25					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146256503	146256503	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:146256503G>C	ENST00000367503.3	-	12	3042	c.2644C>G	c.(2644-2646)Cgg>Ggg	p.R882G	SHPRH_ENST00000438092.2_Missense_Mutation_p.R882G|SHPRH_ENST00000367505.2_Missense_Mutation_p.R882G|SHPRH_ENST00000275233.7_Missense_Mutation_p.R882G	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	882					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CAGTAAGGCCGATAGAGAAGT	0.393000													27	29					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2437145	2437145	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2437145C>T	ENST00000452833.1	-	8	1133	c.1125G>A	c.(1123-1125)gtG>gtA	p.V375V	TRPM5_ENST00000155858.6_Silent_p.V373V|TRPM5_ENST00000533060.1_Silent_p.V373V|TRPM5_ENST00000528453.1_Silent_p.V373V			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	373						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCTTCCACTCCACGTCCCCAT	0.652000													3	8					0	0	1	0	0
ZNF132	7691	broad.mit.edu	37	19	58945977	58945977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58945977G>A	ENST00000254166.3	-	3	1234	c.834C>T	c.(832-834)atC>atT	p.I278I		NM_003433.3	NP_003424.3	P52740	ZN132_HUMAN	zinc finger protein 132	278						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(1)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TATTACCAAGGATTGATTTCT	0.443000													28	74					0	0	1	0	0
MKX	283078	broad.mit.edu	37	10	28024255	28024255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28024255G>A	ENST00000375790.5	-	4	829	c.397C>T	c.(397-399)Cga>Tga	p.R133*	MKX_ENST00000419761.1_Nonsense_Mutation_p.R133*			Q8IYA7	MKX_HUMAN	mohawk homeobox	133					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						TCTGGCTGTCGAACGGTATTC	0.368000													37	72					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53925647	53925647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53925647C>T	ENST00000371445.3	+	1	576	c.521C>T	c.(520-522)cCc>cTc	p.P174L		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	174	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						TACCCTGGCCCCCTAGACCTG	0.716000													3	12					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117696924	117696924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117696924C>T	ENST00000317775.6	-	15	3064	c.2379G>A	c.(2377-2379)atG>atA	p.M793I	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.M793I	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	793	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CATATTCTTCCATGGACATCA	0.522000													12	41					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968384	28968384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28968384G>A	ENST00000359747.4	+	4	300	c.271G>A	c.(271-273)Ggg>Agg	p.G91R	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.G91R|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	91	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTCTGGAGTAGGGATTGATCG	0.403000													17	63					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73484038	73484038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73484038C>T	ENST00000314256.7	+	6	829	c.435C>T	c.(433-435)atC>atT	p.I145I	KIAA0195_ENST00000579208.1_Intron|KIAA0195_ENST00000375248.5_Silent_p.I155I|KIAA0195_ENST00000583795.1_3'UTR	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	145					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCAGGGAGATCCAGTGGCCCA	0.602000													14	49					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154744507	154744507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154744507G>A	ENST00000271915.3	-	3	1707	c.1392C>T	c.(1390-1392)ctC>ctT	p.L464L	KCNN3_ENST00000358505.2_Silent_p.L151L|KCNN3_ENST00000361147.4_Silent_p.L159L	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	469						integral to membrane	calmodulin binding	p.L464L(1)|p.L159L(1)		cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TGCTGAACACGAGCAGCACAG	0.557000													23	67					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197189708	197189708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197189708C>T	ENST00000260983.2	-	6	919	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	HECW2_ENST00000409111.1_5'UTR	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	246	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TCTTACCTCTCGGTGCCAAAT	0.512000													48	102					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723410	58723410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58723410C>T	ENST00000300079.5	+	7	962	c.912C>T	c.(910-912)tcC>tcT	p.S304S	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Silent_p.S273S	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	273						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	ATGAAGACTCCCGCAGATTTG	0.453000													21	77					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35927567	35927567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35927567C>T	ENST00000490799.1	-	15	2008	c.1655G>A	c.(1654-1656)gGg>gAg	p.G552E	SLC26A8_ENST00000394602.2_Missense_Mutation_p.G447E|SLC26A8_ENST00000355574.2_Missense_Mutation_p.G552E	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	552	STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						GATTTTCACCCCAGGAATGGT	0.383000													29	62					0	0	1	0	0
BBS2	583	broad.mit.edu	37	16	56519580	56519580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56519580G>A	ENST00000245157.5	-	16	2401	c.1981C>T	c.(1981-1983)Cgc>Tgc	p.R661C	BBS2_ENST00000568104.1_Missense_Mutation_p.R615C	NM_031885.3	NP_114091.3	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2	661					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)	26						TTGTTACAGCGAATTTTATAT	0.378000									Bardet-Biedl syndrome				24	209					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111957659	111957659	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111957659G>A	ENST00000369732.3	-	11	1519	c.1464C>T	c.(1462-1464)acC>acT	p.T488T		NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	488					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TCTCTCCAGGGGTCATGGACT	0.532000													17	75					0	0	1	0	0
ACY3	91703	broad.mit.edu	37	11	67410302	67410302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67410302C>T	ENST00000255082.3	-	8	1023	c.853G>A	c.(853-855)Gag>Aag	p.E285K	ACY3_ENST00000529256.1_Missense_Mutation_p.E164K	NM_080658.1	NP_542389.1	Q96HD9	ACY3_HUMAN	aspartoacylase (aminocyclase) 3	285					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding			endometrium(1)|lung(5)|prostate(2)	8					L-Aspartic Acid(DB00128)	TAGGCAGCCTCGTTAATGAAC	0.597000													36	54					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121643197	121643197	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121643197G>A	ENST00000489711.1	+	12	1390		c.e12-1		SLC15A2_ENST00000295605.2_Splice_Site	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2						protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AAATGTTTCAGGGGTTTTTTG	0.363000													56	158					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145439658	145439658	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145439658C>T	ENST00000511217.1	+	8	1837	c.1785C>T	c.(1783-1785)tcC>tcT	p.S595S	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Silent_p.S595S			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	595							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGATCCACTCCGCGGCCAGCT	0.632000													21	67					0	0	1	0	0
ATXN7	6314	broad.mit.edu	37	3	63981490	63981490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:63981490C>T	ENST00000398590.3	+	12	2545	c.1992C>T	c.(1990-1992)tcC>tcT	p.S664S	ATXN7_ENST00000487717.1_Silent_p.S664S|ATXN7_ENST00000295900.6_Silent_p.S664S|ATXN7_ENST00000538065.1_Silent_p.S664S|ATXN7_ENST00000484332.1_Silent_p.S519S	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	664	Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		CGGTTCCTTCCTCCCCCATGT	0.512000													44	91					0	0	1	0	0
YPEL4	219539	broad.mit.edu	37	11	57413472	57413472	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57413472C>T	ENST00000524669.1	-	5	3088	c.366G>A	c.(364-366)aaG>aaA	p.K122K	YPEL4_ENST00000534711.1_Silent_p.K122K|AP000662.4_ENST00000530595.1_RNA|YPEL4_ENST00000300022.3_Silent_p.K122K|YPEL4_ENST00000544993.1_Silent_p.K122K			Q96NS1	YPEL4_HUMAN	yippee-like 4 (Drosophila)	122						nucleolus				lung(2)|skin(1)	3						AGCCGTTGTCCTTCACCATGT	0.547000													35	68					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050073	42050073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42050073G>A	ENST00000372584.1	-	3	1410	c.396C>T	c.(394-396)tcC>tcT	p.S132S	HIVEP3_ENST00000429157.2_Silent_p.S132S|HIVEP3_ENST00000372583.1_Silent_p.S132S|HIVEP3_ENST00000247584.5_Silent_p.S132S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	132					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGGCCACGAAGGAGCCAGAGG	0.607000													51	106					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234112908	234112908	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234112908G>A	ENST00000359570.5	+	28	3076	c.3076G>A	c.(3076-3078)Gaa>Aaa	p.1026_1026insK	INPP5D_ENST00000455936.2_Missense_Mutation_p.790_790insK|INPP5D_ENST00000450745.1_Missense_Mutation_p.790_790insK			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	0	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GAAGGACCAGGAATCCCCCAA	0.637000													16	52					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374623	8374623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8374623C>T	ENST00000538603.1	-	7	1748	c.1190G>A	c.(1189-1191)cGg>cAg	p.R397Q	FAM90A1_ENST00000307435.6_Missense_Mutation_p.R397Q	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	397							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		TTCCAGTCTCCGAAAGAGCAC	0.637000													7	31					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41476767	41476767	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41476767C>T	ENST00000314992.5	-	10	1097	c.907G>A	c.(907-909)Gaa>Aaa	p.E303K	EXD1_ENST00000458580.2_Missense_Mutation_p.E361K	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	303					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						TGAAGCAGTTCCTCTGGCAGC	0.408000													32	68					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63955210	63955210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:63955210G>A	ENST00000443617.2	-	44	8961	c.8874C>T	c.(8872-8874)atC>atT	p.I2958I		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2958					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GTACCTCTGGGATCCACATTC	0.468000													8	63					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770514	31770514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:31770514G>A	ENST00000240587.4	-	2	512	c.185C>T	c.(184-186)tCc>tTc	p.S62F		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	62					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GGCGGCCGGGGAGTTCTGGTA	0.587000													15	14					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519159	113519159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113519159C>T	ENST00000284601.3	-	4	2056	c.1988G>A	c.(1987-1989)gGa>gAa	p.G663E		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	663					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TCTTGATTTTCCCTGACTTTC	0.363000													61	164					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529732	5529732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5529732G>A	ENST00000311659.4	-	2	1204	c.1057C>T	c.(1057-1059)Ccc>Tcc	p.P353S	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	353										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGGACTGGGGGTTCTCGTGT	0.498000													46	96					0	0	1	0	0
CSRNP3	80034	broad.mit.edu	37	2	166536025	166536025	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166536025C>T	ENST00000314499.7	+	7	1896	c.1520C>T	c.(1519-1521)tCc>tTc	p.S507F	CSRNP3_ENST00000409420.1_Missense_Mutation_p.S539F|CSRNP3_ENST00000342316.4_Missense_Mutation_p.S507F	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	507					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						TGCTCCTCTTCCGAAAATGAT	0.512000													19	49					0	0	1	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43827047	43827047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43827047G>A	ENST00000420765.1	-	31	4309	c.4127C>T	c.(4126-4128)cCt>cTt	p.P1376L	PPIP5K1_ENST00000381885.1_Missense_Mutation_p.P1372L|PPIP5K1_ENST00000360301.4_Missense_Mutation_p.P1351L|PPIP5K1_ENST00000348806.6_Missense_Mutation_p.P1349L|PPIP5K1_ENST00000396923.3_Missense_Mutation_p.P1376L|PPIP5K1_ENST00000360135.4_Missense_Mutation_p.P1349L|PPIP5K1_ENST00000381879.4_Missense_Mutation_p.P1352L|PPIP5K1_ENST00000334933.4_Missense_Mutation_p.P1351L	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1376					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						GACCTCCTCAGGGATCTCTTC	0.547000													49	97					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48390632	48390632	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48390632C>T	ENST00000224600.4	-	1	359	c.246G>A	c.(244-246)ctG>ctA	p.L82L		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	82	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GAGGATCGTTCAGGGAGCTCT	0.612000													31	59					0	0	1	0	0
IGHV4-4	28401	broad.mit.edu	37	14	106478215	106478215	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106478215G>A	ENST00000390596.2	-	0	306																											GACTCTTGAGGGAGGGGTTGT	0.572000													11	98					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61028352	61028352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61028352C>T	ENST00000373867.3	-	9	1119	c.654G>A	c.(652-654)cgG>cgA	p.R218R	FAM13C_ENST00000422313.2_Silent_p.R301R|FAM13C_ENST00000435852.2_Silent_p.R301R|FAM13C_ENST00000468840.2_Silent_p.R218R|FAM13C_ENST00000442566.3_Silent_p.R322R|FAM13C_ENST00000419214.2_Silent_p.R301R|FAM13C_ENST00000373868.2_Silent_p.R301R|FAM13C_ENST00000277705.6_Silent_p.R322R	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	301										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTTCAAATTTCCGAATTTTCC	0.507000													23	49					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67051805	67051805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67051805C>T	ENST00000308595.5	+	18	1905	c.1615C>T	c.(1615-1617)Cgc>Tgc	p.R539C	ADRBK1_ENST00000527176.1_3'UTR|ADRBK1_ENST00000526285.1_Intron	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	539					activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCTGGAGGCTCGCAAGAAAGC	0.627000													7	46					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107732116	107732116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107732116G>A	ENST00000388781.3	-	14	1739	c.1656C>T	c.(1654-1656)ctC>ctT	p.L552L	LAMB4_ENST00000205386.4_Silent_p.L552L|LAMB4_ENST00000414450.2_Silent_p.L552L|LAMB4_ENST00000388780.3_Silent_p.L552L	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	552	Laminin EGF-like 5; truncated.|Laminin IV type B.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CTGCCTCGTAGAGATAGAAAT	0.493000													32	90					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71056346	71056346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71056346C>T	ENST00000283228.2	-	11	1989	c.1537G>A	c.(1537-1539)Gga>Aga	p.G513R	PTPRR_ENST00000537619.2_5'UTR|PTPRR_ENST00000549308.1_Missense_Mutation_p.G268R|PTPRR_ENST00000440835.2_Missense_Mutation_p.G268R|PTPRR_ENST00000342084.4_Missense_Mutation_p.G401R|PTPRR_ENST00000378778.1_Missense_Mutation_p.G307R	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	513	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TCAACTTTTCCATATATCCCT	0.373000													15	56					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17246733	17246733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:17246733C>T	ENST00000285681.2	+	23	3152	c.2783C>T	c.(2782-2784)tCc>tTc	p.S928F	USP25_ENST00000400183.2_Missense_Mutation_p.S966F|USP25_ENST00000351097.5_Missense_Mutation_p.S291F|USP25_ENST00000285679.6_Missense_Mutation_p.S896F			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	896					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TATATAGATTCCTTGCTGTTC	0.284000													26	51					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	54025254	54025254	+	Silent	SNP	C	C	T	rs148643501	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54025254C>T	ENST00000396328.1	-	2	332	c.93G>A	c.(91-93)acG>acA	p.T31T	WDR72_ENST00000360509.5_Silent_p.T31T|WDR72_ENST00000559418.1_Silent_p.T31T|WDR72_ENST00000557913.1_Silent_p.T31T	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	31										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		CAGTCACAATCGTTCGCTGGT	0.512000													40	110					0	0	1	0	0
IGHV5-51	28388	broad.mit.edu	37	14	107034732	107034732	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107034732C>T	ENST00000390626.2	-	0	406																											CTGTGTGTCTCGCACAGTAAT	0.597000													17	160					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64880991	64880991	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64880991C>T	ENST00000169565.3	+	4	783	c.783C>T	c.(781-783)ccC>ccT	p.P261P	CACNG5_ENST00000307139.3_Intron|CACNG5_ENST00000533854.1_Intron			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	0				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GCTCCTGTCCCCACGTCCACT	0.612000													23	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8997177	8997177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8997177G>A	ENST00000397910.4	-	60	41222	c.41019C>T	c.(41017-41019)tcC>tcT	p.S13673S	MUC16_ENST00000380951.5_Silent_p.S314S	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13675	SEA 11.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTTGAACAGGGACCTGAGCT	0.587000													25	67					0	0	1	0	0
IGF2BP2-AS1	646600	broad.mit.edu	37	3	185434297	185434297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185434297G>A	ENST00000296270.1	+	2	266	c.130G>A	c.(130-132)Gga>Aga	p.G44R	IGF2BP2_ENST00000457616.2_Intron|IGF2BP2_ENST00000421047.2_Intron|IGF2BP2_ENST00000382199.2_Intron|IGF2BP2_ENST00000346192.3_Intron																		all_cancers(143;1.5e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			CAGCTTTTGGGGAAGTGGGCT	0.458000													8	114					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87679348	87679348	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87679348G>A	ENST00000320005.5	-	6	704	c.657C>T	c.(655-657)ctC>ctT	p.L219L		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	219					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AGAGCCACAGGAGATAGAGTC	0.448000													9	29					0	0	1	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6094294	6094294	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:6094294G>A	ENST00000199389.6	-	2	306	c.160C>T	c.(160-162)Cta>Tta	p.L54L	EIF2AK1_ENST00000536084.1_5'UTR	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	54					negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GGCTGTTGTAGGGGTTCTTTT	0.393000													42	140					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56127839	56127839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56127839G>A	ENST00000303039.3	+	1	149	c.117G>A	c.(115-117)atG>atA	p.M39I		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					GGCTGACCATGGCAGGGAACC	0.498000													47	117					0	0	1	0	0
MTAP	4507	broad.mit.edu	37	9	21854633	21854633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21854633C>T	ENST00000380172.4	+	6	660	c.454C>T	c.(454-456)Ctt>Ttt	p.L152F	RP11-145E5.5_ENST00000404796.2_Intron|MTAP_ENST00000580900.1_Missense_Mutation_p.L152F|MTAP_ENST00000460874.2_Missense_Mutation_p.L169F	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	152					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	TTTCTAGGTTCTTATAGAGAC	0.443000													11	91					0	0	1	0	0
CT47A6	728062	broad.mit.edu	37	X	120094389	120094389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:120094389C>T	ENST00000443600.2	-	1	948	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K	CT47A5_ENST00000419194.2_Intron	NM_001080141.1	NP_001073610.1	Q5JQC4	CT47A_HUMAN	cancer/testis antigen family 47, member A6	232										large_intestine(1)|lung(4)	5						GTGGCTGGTTCCTCTGCGTCT	0.682000													249	2					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111671488	111671488	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111671488C>T	ENST00000431670.2	+	11	3112	c.2701C>T	c.(2701-2703)Cga>Tga	p.R901*	PHLDB2_ENST00000412622.1_Nonsense_Mutation_p.R858*|PHLDB2_ENST00000495180.1_Intron|PHLDB2_ENST00000481953.1_Nonsense_Mutation_p.R858*|PHLDB2_ENST00000393925.3_Nonsense_Mutation_p.R901*|PHLDB2_ENST00000393923.3_Nonsense_Mutation_p.R885*	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	901						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TACTTTGCCTCGAAAGAAAAC	0.443000													31	82					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151376574	151376574	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151376574C>T	ENST00000370314.4	-	7	915	c.677G>A	c.(676-678)gGa>gAa	p.G226E	GABRA3_ENST00000535043.1_Missense_Mutation_p.G226E|GABRA3_ENST00000370311.1_Missense_Mutation_p.G226E	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	226					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTTGTTCTTTCCGAGAGTCCA	0.443000													56	35					0	0	1	0	0
C9orf24	84688	broad.mit.edu	37	9	34381390	34381390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34381390C>T	ENST00000297623.2	-	4	647	c.449G>A	c.(448-450)aGg>aAg	p.R150K	C9orf24_ENST00000379124.1_Missense_Mutation_p.R15K|C9orf24_ENST00000379133.3_Missense_Mutation_p.R15K|C9orf24_ENST00000379127.1_Missense_Mutation_p.R15K|C9orf24_ENST00000379126.3_Missense_Mutation_p.R15K	NM_032596.3	NP_115985.2	Q8NCR6	CI024_HUMAN	chromosome 9 open reading frame 24	150										endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)		CCGCTCCGGCCTAGGAGGGCA	0.617000													36	117					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50611760	50611760	+	Silent	SNP	C	C	T	rs74987565	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50611760C>T	ENST00000444124.2	-	2	224	c.24G>A	c.(22-24)agG>agA	p.R8R	DDC_ENST00000431062.1_Silent_p.R8R|DDC_ENST00000380984.4_Silent_p.R8R|DDC_ENST00000357936.5_Silent_p.R8R|DDC_ENST00000426377.1_Silent_p.R8R	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	8					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CCTTCCCTCTCCTTCGGAATT	0.522000													58	154					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128608858	128608858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:128608858C>T	ENST00000335251.5	+	8	1388	c.1285C>T	c.(1285-1287)Cct>Tct	p.P429S		NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	429										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						TGAGAATGTTCCTCGTTTGGA	0.438000													31	96					0	0	1	0	0
TMEM173	340061	broad.mit.edu	37	5	138855874	138855874	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:138855874G>A	ENST00000330794.4	-	8	1445	c.1112C>T	c.(1111-1113)cCc>cTc	p.P371L		NM_198282.2	NP_938023.1	Q86WV6	TM173_HUMAN	transmembrane protein 173	371					activation of innate immune response|apoptosis|cellular response to exogenous dsRNA|defense response to virus|innate immune response|interferon-beta production|positive regulation of defense response to virus by host|positive regulation of protein binding|positive regulation of protein import into nucleus, translocation|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane|perinuclear region of cytoplasm|plasma membrane	protein homodimerization activity|protein kinase binding|transcription factor binding			endometrium(1)|kidney(1)|lung(6)|upper_aerodigestive_tract(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GAGAGGGAGGGGCTTTTCCAT	0.592000													3	6					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220108019	220108019	+	Silent	SNP	G	G	A	rs13388808		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220108019G>A	ENST00000295759.7	-	3	403	c.90C>T	c.(88-90)ttC>ttT	p.F30F	GLB1L_ENST00000409640.1_Silent_p.F30F|GLB1L_ENST00000356283.3_Silent_p.F30F|GLB1L_ENST00000392089.2_Silent_p.F30F			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	30					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TATCCACTACGAACGACCGAG	0.602000													32	75					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348083	220348083	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220348083G>A	ENST00000312358.7	+	30	6030	c.5898G>A	c.(5896-5898)ggG>ggA	p.G1966G	SPEG_ENST00000485813.1_3'UTR|AC053503.11_ENST00000429882.1_RNA	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1966					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CAGAGACTGGGGCTGCCACCC	0.701000													6	18					0	0	1	0	0
PMCH	5367	broad.mit.edu	37	12	102591323	102591323	+	Missense_Mutation	SNP	C	C	T	rs141964854		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102591323C>T	ENST00000329406.4	-	1	300	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K		NM_002674.2	NP_002665.2	P20382	MCH_HUMAN	pro-melanin-concentrating hormone	76					cell differentiation|neuropeptide signaling pathway|spermatogenesis|synaptic transmission		melanin-concentrating hormone activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	6						TTTTCCTCTTCGTTCATGAAA	0.348000													24	84					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52540749	52540749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52540749G>A	ENST00000321725.6	+	18	1948	c.1872G>A	c.(1870-1872)agG>agA	p.R624R		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	624	FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CGCTGCAGAGGGTAGACGTGA	0.692000													5	22					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130059685	130059685	+	Silent	SNP	C	C	T	rs142848651	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130059685C>T	ENST00000278742.5	+	5	910	c.492C>T	c.(490-492)caC>caT	p.H164H		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	164					proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	TCCCGCAGCACCTGGTGGAGG	0.677000													50	110					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43531170	43531170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43531170G>A	ENST00000220420.5	-	9	1197	c.1190C>T	c.(1189-1191)tCg>tTg	p.S397L	TGM5_ENST00000349114.4_Missense_Mutation_p.S315L	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	397					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	ATTCACCATCGAAAACACAAA	0.527000													14	55					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145442113	145442113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145442113C>T	ENST00000511217.1	+	9	2091	c.2039C>T	c.(2038-2040)tCc>tTc	p.S680F	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Missense_Mutation_p.S680F			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	680							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAAGCAGCGTCCTTGGGCCCA	0.597000													8	78					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71277022	71277022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71277022C>T	ENST00000398531.1	+	1	414	c.389C>T	c.(388-390)tCc>tTc	p.S130F	KRTAP5-10_ENST00000376536.4_Missense_Mutation_p.S82F	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	130	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGTGGGGGCTCCAAGGGGGGC	0.652000													48	180					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110819862	110819862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110819862G>A	ENST00000282356.4	+	11	1518	c.1120G>A	c.(1120-1122)Gaa>Aaa	p.E374K	CAMK4_ENST00000512453.1_Missense_Mutation_p.E374K|CAMK4_ENST00000512890.1_3'UTR	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	374					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		AGCTATTCCAGAAGGAGAGAA	0.537000													15	75					0	0	1	0	0
KITLG	4254	broad.mit.edu	37	12	88910190	88910190	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:88910190G>A	ENST00000347404.5	-	5	1013	c.441C>T	c.(439-441)tcC>tcT	p.S147S	KITLG_ENST00000357116.4_Intron|KITLG_ENST00000228280.5_Silent_p.S147S|KITLG_ENST00000378535.4_5'UTR	NM_003994.5	NP_003985.2	P21583	SCF_HUMAN	KIT ligand	147					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)	9						AGGCATCAATGGATCTATTAA	0.358000									Testicular Cancer, Familial Clustering of				22	73					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94055164	94055164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94055164G>A	ENST00000297268.6	+	44	3409	c.2938G>A	c.(2938-2940)Gaa>Aaa	p.E980K		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	980				E -> V (in Ref. 21; AAA51996).	axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AAACCGTGGTGAAACTGTAAG	0.577000										HNSCC(75;0.22)			3	13					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17434544	17434544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:17434544C>T	ENST00000262545.2	+	9	1358	c.1043C>T	c.(1042-1044)tCt>tTt	p.S348F	PCSK2_ENST00000536609.1_Missense_Mutation_p.S313F|PCSK2_ENST00000377899.1_Missense_Mutation_p.S329F	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	348	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAGAGCTGCTCTTCCACCTTG	0.597000													25	70					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91844621	91844621	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:91844621G>A	ENST00000370425.3	-	9	1255	c.1158_splice	c.e9+1	p.P386_splice	HFM1_ENST00000294696.5_5'UTR|HFM1_ENST00000370424.3_Splice_Site_p.P65_splice	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	386	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AATACCTACTGGAGTTGTCAT	0.264000													18	27					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78401191	78401191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:78401191C>T	ENST00000397909.2	+	8	2046	c.1873C>T	c.(1873-1875)Ccg>Tcg	p.P625S	NAV3_ENST00000228327.6_Missense_Mutation_p.P625S|NAV3_ENST00000536525.2_Missense_Mutation_p.P625S|NAV3_ENST00000266692.7_Missense_Mutation_p.P625S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	625						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACATAGCCACCCGAATACCGC	0.478000										HNSCC(70;0.22)			33	104					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348124	140348124	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348124C>T	ENST00000289269.5	+	1	2305	c.1773C>T	c.(1771-1773)ttC>ttT	p.F591F	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		591					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCAGCCTTCGAGATGGTGC	0.517000													19	33					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62748477	62748477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62748477G>A	ENST00000377871.3	-	6	1283	c.1017C>T	c.(1015-1017)ttC>ttT	p.F339F	SLC22A6_ENST00000458333.2_Silent_p.F339F|SLC22A6_ENST00000421062.2_Silent_p.F339F|SLC22A6_ENST00000360421.4_Silent_p.F339F|SLC22A6_ENST00000537349.1_5'UTR	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	339					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						AGAGGCAGAGGAAGAGGTGGC	0.617000													21	50					0	0	1	0	0
IGHV1-45	28466	broad.mit.edu	37	14	106963149	106963149	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106963149C>T	ENST00000390621.2	-	0	190																											AAGGTGTATCCGGAAGCCTTG	0.572000													53	101					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84050173	84050173	+	Silent	SNP	G	G	A	rs113073498	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84050173G>A	ENST00000299709.3	-	8	1112	c.1113C>T	c.(1111-1113)atC>atT	p.I371I		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	371					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						TGATGCTGACGATCTCGCTGA	0.592000													16	61					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537447	55537447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55537447G>A	ENST00000220676.1	+	4	1153	c.1005G>A	c.(1003-1005)atG>atA	p.M335I		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	335					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.M335I(1)		NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CAGTTGAGATGAAAGTTCGAT	0.313000													19	35					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2808778	2808778	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2808778G>A	ENST00000520002.1	-	67	10617	c.10062C>T	c.(10060-10062)ttC>ttT	p.F3354F	CSMD1_ENST00000542608.1_Silent_p.F3176F|CSMD1_ENST00000400186.3_Silent_p.F3177F|CSMD1_ENST00000602557.1_Silent_p.F3354F|CSMD1_ENST00000537824.1_Silent_p.F3353F|CSMD1_ENST00000602723.1_Silent_p.F3177F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3354						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGAATTGACGAAAAAGACAT	0.413000													6	17					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15809077	15809077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15809077C>T	ENST00000338282.6	-	39	5663	c.5557G>A	c.(5557-5559)Gaa>Aaa	p.E1853K	NDE1_ENST00000396354.1_Intron|MYH11_ENST00000576790.1_Missense_Mutation_p.E1853K|NDE1_ENST00000396355.1_Intron|MYH11_ENST00000396324.3_Missense_Mutation_p.E1860K|NDE1_ENST00000342673.5_Intron|MYH11_ENST00000452625.2_Missense_Mutation_p.E1860K|MYH11_ENST00000300036.5_Missense_Mutation_p.E1853K	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1853					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						AGCAAGATTTCCTTCAGCTTC	0.607000			T	CBFB	AML								31	69					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28736065	28736065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28736065G>A	ENST00000257197.3	-	4	673	c.412C>T	c.(412-414)Cct>Tct	p.P138S	DSC1_ENST00000257198.5_Missense_Mutation_p.P138S|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	138	Cadherin 1.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GCTGGAATAGGAGCCCATCGT	0.408000													43	75					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17280797	17280797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17280797C>T	ENST00000375541.5	+	22	3335	c.3266C>T	c.(3265-3267)tCc>tTc	p.S1089F	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1089					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCCACCATCTCCCTGGAGATG	0.627000													37	97					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427724	119427724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119427724G>A	ENST00000369429.3	-	8	1449	c.1440C>T	c.(1438-1440)gtC>gtT	p.V480V	TBX15_ENST00000207157.3_Silent_p.V374V			Q96SF7	TBX15_HUMAN	T-box 15	480						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CTGCCTGCATGACATACTGAA	0.567000													12	28					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960771	73960771	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73960771C>T	ENST00000373468.1	-	3	4272	c.3621G>A	c.(3619-3621)ggG>ggA	p.G1207G	KIAA2022_ENST00000055682.5_Silent_p.G1207G			Q5QGS0	K2022_HUMAN	KIAA2022	1207					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GTTTTTCAATCCCCTTGTTGT	0.438000													28	18					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32526597	32526597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32526597C>T	ENST00000286827.3	-	18	3610	c.3139G>A	c.(3139-3141)Gag>Aag	p.E1047K	TIAM1_ENST00000541036.1_Missense_Mutation_p.E987K	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1047	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TCCAGGAGCTCGCAGATCACC	0.582000													30	18					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375047	113375047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113375047G>A	ENST00000316407.4	-	7	5892	c.5482C>T	c.(5482-5484)Ctc>Ttc	p.L1828F	KIAA2018_ENST00000478658.1_Missense_Mutation_p.L1828F|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1828					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGATCACTGAGGTGAGGGGCA	0.473000													47	167					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45024569	45024569	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45024569G>A	ENST00000454753.1	-	0	1247							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				AGACCTCACAGGCATAGGGCC	0.642000													20	47					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115130449	115130449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115130449G>A	ENST00000393274.1	-	19	3181	c.2556C>T	c.(2554-2556)ttC>ttT	p.F852F	DENND2C_ENST00000393277.1_Silent_p.F740F|DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Silent_p.F795F	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	852	dDENN.									NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGACTTACGGAATGGTTCCC	0.483000													17	49					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58107029	58107029	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58107029G>A	ENST00000357272.4	+	20	3090	c.2925G>A	c.(2923-2925)ggG>ggA	p.G975G	FLNB_ENST00000493452.1_Silent_p.G806G|FLNB_ENST00000490882.1_Silent_p.G975G|FLNB_ENST00000429972.2_Silent_p.G975G|FLNB_ENST00000419752.2_Silent_p.G806G|FLNB_ENST00000348383.5_Silent_p.G975G|FLNB_ENST00000295956.4_Silent_p.G975G|FLNB_ENST00000358537.3_Silent_p.G975G			O75369	FLNB_HUMAN	filamin B, beta	975					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GAGGCCAGGGGAAGCTGGACG	0.587000													46	110					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064099	6064099	+	Silent	SNP	G	G	A	rs149678000	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6064099G>A	ENST00000409021.3	-	10	1949	c.1500C>T	c.(1498-1500)cgC>cgT	p.R500R	JAKMIP1_ENST00000410077.2_Silent_p.R335R|JAKMIP1_ENST00000409831.1_Silent_p.R500R|JAKMIP1_ENST00000409371.3_Silent_p.R315R|JAKMIP1_ENST00000282924.5_Silent_p.R500R	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	500	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GGGCGTAGGCGCGTTGCAGGG	0.642000													26	72					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449721	35449721	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35449721G>A	ENST00000404801.1	-	4	1424	c.1038C>T	c.(1036-1038)ttC>ttT	p.F346F	ZNF792_ENST00000605484.1_Silent_p.F279F	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TTCGGCTGAAGAATTTCCCAC	0.507000													15	32					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531893	50531893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50531893G>A	ENST00000374144.3	+	3	1591	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K	C10orf71_ENST00000323868.4_Missense_Mutation_p.E435K			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	435										endometrium(1)	1						GGAACCCAATGAACATTATGA	0.512000													27	87					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100226909	100226909	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100226909C>G	ENST00000524871.1	+	25	3551	c.3261C>G	c.(3259-3261)gtC>gtG	p.V1087V	CNTN5_ENST00000528682.1_Silent_p.V1087V|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Silent_p.V1087V|CNTN5_ENST00000418526.2_Silent_p.V1013V	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	1087					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CGTCATCAGTCACCTTGCTCT	0.418000													6	20					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26866495	26866495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:26866495G>A	ENST00000541819.2	-	5	697	c.595C>T	c.(595-597)Ctt>Ttt	p.L199F	GABRB3_ENST00000545868.1_Missense_Mutation_p.L58F|GABRB3_ENST00000299267.4_Missense_Mutation_p.L143F|GABRB3_ENST00000311550.5_Missense_Mutation_p.L143F|GABRB3_ENST00000400188.3_Missense_Mutation_p.L72F			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	143					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCAGGGTGAAGACGGATCATG	0.478000													34	105					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56026089	56026089	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:56026089C>T	ENST00000288221.6	-	11	2506	c.2251G>A	c.(2251-2253)Gag>Aag	p.E751K		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	751						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		ATTTACCTCTCCAGTTCTGCG	0.483000													9	152					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848257	73848257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73848257G>A	ENST00000523207.1	+	3	1255	c.667G>A	c.(667-669)Gaa>Aaa	p.E223K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	223					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GGAAACGGACGAATTTGGACA	0.478000													54	113					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45817352	45817352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45817352C>T	ENST00000358525.4	-	4	598	c.483G>A	c.(481-483)caG>caA	p.Q161Q	SLC6A20_ENST00000353278.4_Silent_p.Q161Q|SLC6A20_ENST00000456124.2_Silent_p.Q161Q	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	161					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CCCCGTTCTCCTGGAGGGACG	0.607000													40	143					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42231011	42231011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42231011G>A	ENST00000541110.1	-	8	2499	c.1931C>T	c.(1930-1932)cCc>cTc	p.P644L	TRERF1_ENST00000340840.2_Intron|TRERF1_ENST00000354325.2_Intron|TRERF1_ENST00000372917.4_Intron|TRERF1_ENST00000372922.4_Intron			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	628	Interacts with CREBBP.|Pro-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGGCGTGCGGGGGGCAGCCCC	0.647000													35	56					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88387520	88387520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:88387520G>A	ENST00000419482.2	+	3	539	c.454G>A	c.(454-456)Gac>Aac	p.D152N	SMYD1_ENST00000444564.2_Missense_Mutation_p.D152N|SMYD1_ENST00000468008.1_3'UTR|SMYD1_ENST00000438570.1_Intron	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	152	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						GGTGGACGTGGACACATTCTT	0.622000													18	61					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62652709	62652709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:62652709G>A	ENST00000337910.5	-	5	678	c.341C>T	c.(340-342)tCc>tTc	p.S114F	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.S114F	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	114	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					ATGATTTAGGGAATTGGGATT	0.408000													30	110					0	0	1	0	0
RPAP1	26015	broad.mit.edu	37	15	41819639	41819639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41819639G>A	ENST00000304330.4	-	12	1709	c.1593C>T	c.(1591-1593)gcC>gcT	p.A531A	RPAP1_ENST00000561603.1_Silent_p.A531A	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	531						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CATCATGTCGGGCCAGGTCAG	0.552000													21	75					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143104721	143104721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143104721C>T	ENST00000275815.3	-	2	219	c.133G>A	c.(133-135)Gat>Aat	p.D45N		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	45						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TTTGGGGGATCCAGCAGCCAG	0.562000													34	368					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262588	140262588	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140262588C>T	ENST00000289272.2	+	1	735	c.735C>T	c.(733-735)tcC>tcT	p.S245S	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.S245S|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTACCAATCCGTTTATAAAG	0.453000													34	96					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94670698	94670698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94670698C>T	ENST00000260526.6	-	7	798	c.616G>A	c.(616-618)Gag>Aag	p.E206K	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.E206K	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	206					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		AAAGCCAGCTCGATAGAGTCA	0.338000													14	53					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57017042	57017042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:57017042C>T	ENST00000370706.4	+	12	3020	c.2776C>T	c.(2776-2778)Ccg>Tcg	p.P926S	RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|RP11-203B9.4_ENST00000589263.1_RNA|ZNF451_ENST00000357489.3_Missense_Mutation_p.P878S|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.P926S|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000586466.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	926					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTGGAAGCCTCCGCTCAACTG	0.363000													29	59					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15296161	15296161	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15296161G>A	ENST00000263388.2	-	14	2278	c.2203C>T	c.(2203-2205)Cga>Tga	p.R735*		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	735	EGF-like 19.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CAGGCGTCTCGGGCCAGGCTC	0.677000													8	20					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620138	7620138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:7620138C>T	ENST00000486284.1	+	8	1819	c.1545C>T	c.(1543-1545)gtC>gtT	p.V515V	GRM7_ENST00000403881.1_Silent_p.V515V|GRM7_ENST00000389336.4_Silent_p.V515V|GRM7_ENST00000402647.2_Silent_p.V515V|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000357716.4_Silent_p.V515V	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	515					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GTAAAGGAGTCCGAGAGATAC	0.463000													18	55					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985517	108985517	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108985517C>T	ENST00000392806.3	-	2	811	c.643G>A	c.(643-645)Ggg>Agg	p.G215R		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	215						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						TCCTGGTCCCCCTCCTGGCTG	0.687000													25	63					0	0	1	0	0
SPRY2	10253	broad.mit.edu	37	13	80911411	80911411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:80911411G>A	ENST00000377102.1	-	2	1407	c.430C>T	c.(430-432)Cct>Tct	p.P144S	SPRY2_ENST00000540649.1_Missense_Mutation_p.P144S|SPRY2_ENST00000377104.3_Missense_Mutation_p.P144S			O43597	SPY2_HUMAN	sprouty homolog 2 (Drosophila)	144					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	12	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		TCAGCAACAGGCCCGGAGGAG	0.562000													21	57					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37690748	37690748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37690748C>T	ENST00000248901.6	+	3	337	c.150C>T	c.(148-150)ttC>ttT	p.F50F	CYTH4_ENST00000439667.1_3'UTR|CYTH4_ENST00000402997.1_Silent_p.F50F|CYTH4_ENST00000405206.3_Silent_p.F50F	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	50					regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						TCGACTGCTTCGAGAGTGCGG	0.592000													35	73					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124305219	124305219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124305219C>T	ENST00000409039.3	+	23	3764	c.3739C>T	c.(3739-3741)Cct>Tct	p.P1247S		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1247	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTTCGATCTTCCTATTACAAT	0.443000													21	76					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10468850	10468850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10468850G>A	ENST00000382483.3	-	4	2981	c.2758C>T	c.(2758-2760)Cgg>Tgg	p.R920W		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	920					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GACAGCCCCCGAGACCCCGCA	0.706000													4	32					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846645	47846645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47846645G>A	ENST00000339488.4	-	3	1968	c.1935C>T	c.(1933-1935)ccC>ccT	p.P645P		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	645						integral to membrane	hedgehog receptor activity										AGACAAAGGAGGGGTTGAACA	0.473000													34	158					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165182897	165182897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165182897G>A	ENST00000342310.3	-	5	1032	c.650C>T	c.(649-651)tCc>tTc	p.S217F	LMX1A_ENST00000294816.2_Missense_Mutation_p.S217F|LMX1A_ENST00000367893.4_Missense_Mutation_p.S217F	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	217						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					GGGCTTGGAGGATACTTCAAA	0.562000													60	124					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057787	9057787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9057787C>T	ENST00000397910.4	-	3	29862	c.29659G>A	c.(29659-29661)Gag>Aag	p.E9887K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9889	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGGTGGTCTCTTCAGAGGTG	0.453000													35	71					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54805108	54805108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54805108C>T	ENST00000306858.7	+	5	1455	c.1339C>T	c.(1339-1341)Cgg>Tgg	p.R447W		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	447										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTTTGCCAATCGGCTTGCGCA	0.458000													13	58					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95069791	95069791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95069791G>A	ENST00000371501.4	-	53	6255	c.6133C>T	c.(6133-6135)Ctc>Ttc	p.L2045F	MYOF_ENST00000358334.5_Missense_Mutation_p.L2032F|MYOF_ENST00000359263.4_Missense_Mutation_p.L2045F|MYOF_ENST00000371502.4_Missense_Mutation_p.L2035F			Q9NZM1	MYOF_HUMAN	myoferlin	2045					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AAAGAGTAGAGGAGCACGGCC	0.562000													19	33					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915173	46915173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46915173C>T	ENST00000307522.3	-	1	1668	c.895G>A	c.(895-897)Gct>Act	p.A299T		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	299						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTATCTGCAGCCTCTCCCCCC	0.647000													71	153					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22348106	22348106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:22348106G>A	ENST00000344041.6	-	5	385	c.73C>T	c.(73-75)Caa>Taa	p.Q25*	RAPGEF5_ENST00000405243.1_Nonsense_Mutation_p.Q178*	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	0					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						TAAGTATCTTGAAAGTATAGA	0.294000													5	8					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69334630	69334630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69334630G>A	ENST00000305363.4	+	4	356	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	98	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TCCATTAAGGGAAGAATTTGT	0.294000													37	192					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19520786	19520786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:19520786C>T	ENST00000507958.1	-	12	2482	c.1492G>A	c.(1492-1494)Gaa>Aaa	p.E498K	CDH18_ENST00000506372.1_Missense_Mutation_p.E498K|CDH18_ENST00000382275.1_Missense_Mutation_p.E498K|CDH18_ENST00000274170.4_Missense_Mutation_p.E498K|CDH18_ENST00000502796.1_Missense_Mutation_p.E498K|CDH18_ENST00000511273.1_Missense_Mutation_p.E498K			Q13634	CAD18_HUMAN	cadherin 18, type 2	498	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TTAGAATTTTCACATACAATA	0.373000													22	57					0	0	1	0	0
ALDH9A1	223	broad.mit.edu	37	1	165652225	165652225	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165652225G>A	ENST00000354775.4	-	3	754	c.450C>T	c.(448-450)tcC>tcT	p.S150S	ALDH9A1_ENST00000538148.1_Silent_p.S56S|ALDH9A1_ENST00000461664.1_5'UTR	NM_000696.3	NP_000687.3	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9 family, member A1	126				C -> Q (in Ref. 7; AA sequence).	carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	21	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	TACCAGCCATGGATGCAGCCA	0.502000													28	50					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586169	20586169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20586169C>T	ENST00000315543.4	+	1	604	c.604C>T	c.(604-606)Ccc>Tcc	p.P202S		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTTTTGTGGTCCCAATGTGGT	0.438000													65	153					0	0	1	0	0
IGHV1-58	28464	broad.mit.edu	37	14	107078517	107078517	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107078517C>T	ENST00000390628.2	-	0	267																											CAACGACGATCCATCCTATCC	0.522000													17	106					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31457512	31457512	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31457512G>A	ENST00000322054.5	+	1	310	c.25G>A	c.(25-27)Gac>Aac	p.D9N	EHD3_ENST00000541626.1_Missense_Mutation_p.D9N	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	9					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					GGGTACGGACGACCGCCGGAG	0.642000													25	61					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12918988	12918988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12918988G>A	ENST00000240189.2	+	2	211	c.124G>A	c.(124-126)Gag>Aag	p.E42K		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	42										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTCTTCAGGGAGGCCTTCAG	0.597000													43	213					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887664	97887664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97887664G>A	ENST00000356526.2	+	1	121	c.121G>A	c.(121-123)Ggg>Agg	p.G41R		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						CACCATCATGGGGAATCTTGG	0.408000													89	229					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42279563	42279563	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42279563C>T	ENST00000399518.3	-	17	2328	c.1842G>A	c.(1840-1842)ccG>ccA	p.P614P	CTD-2382E5.1_ENST00000499478.2_RNA|PLA2G4E_ENST00000413860.2_Silent_p.P585P	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	602	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		CAGGCAGGATCGGCTCGTCTT	0.562000													10	24					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118511610	118511610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:118511610G>A	ENST00000359236.5	-	5	1389	c.1113C>T	c.(1111-1113)acC>acT	p.T371T		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	371	Ig-like C2-type 4.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						GGATAGTGAGGGTGGAGTTCT	0.587000													7	43					0	0	1	0	0
GDF9	2661	broad.mit.edu	37	5	132199880	132199880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132199880G>A	ENST00000378673.2	-	2	1212	c.346C>T	c.(346-348)Ctc>Ttc	p.L116F	GDF9_ENST00000464378.1_5'UTR|GDF9_ENST00000296875.2_Missense_Mutation_p.L116F			O60383	GDF9_HUMAN	growth differentiation factor 9	116					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGGGTGAAGAGCCGAACAGTG	0.483000													28	107					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71139691	71139691	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71139691G>A	ENST00000283228.2	-	6	1366	c.914C>T	c.(913-915)cCt>cTt	p.P305L	PTPRR_ENST00000549308.1_Missense_Mutation_p.P60L|PTPRR_ENST00000440835.2_Missense_Mutation_p.P60L|PTPRR_ENST00000342084.4_Missense_Mutation_p.P193L|PTPRR_ENST00000378778.1_Missense_Mutation_p.P99L	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	305					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TCGGCCTTGAGGGTCCACGAC	0.532000													24	37					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21954063	21954063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21954063C>T	ENST00000261200.4	-	38	4564	c.4565G>A	c.(4564-4566)gGa>gAa	p.G1522E		NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1522	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.G1522E(1)		NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TAAAATATTTCCTCGCTTCAT	0.408000													8	70					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56297165	56297165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56297165C>T	ENST00000443188.1	-	12	3638	c.2928G>A	c.(2926-2928)ttG>ttA	p.L976L	NLRP11_ENST00000589093.1_Silent_p.L976L|NLRP11_ENST00000592953.1_Silent_p.L877L|NLRP11_ENST00000360133.3_Silent_p.L922L|NLRP11_ENST00000589824.2_Silent_p.L922L	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	976							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ACAGAAAGATCAAACTGGGTT	0.423000													32	82					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201752810	201752810	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201752810C>T	ENST00000367296.4	+	7	3054	c.2634C>T	c.(2632-2634)ctC>ctT	p.L878L	NAV1_ENST00000367300.3_Silent_p.L878L|NAV1_ENST00000367297.4_Silent_p.L878L|NAV1_ENST00000367295.1_Silent_p.L487L|NAV1_ENST00000469130.1_3'UTR|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000295624.6_Silent_p.L878L|NAV1_ENST00000367302.1_Silent_p.L891L	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	878					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						ACCCCAAACTCTCAGGCCTGC	0.597000													35	72					0	0	1	0	0
MAK	4117	broad.mit.edu	37	6	10796537	10796537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:10796537C>T	ENST00000313243.2	-	9	1219	c.837G>A	c.(835-837)ttG>ttA	p.L279L	MAK_ENST00000538030.1_Silent_p.L279L|SYCP2L_ENST00000543878.1_Intron|MAK_ENST00000474039.1_Silent_p.L279L|RP11-637O19.3_ENST00000480294.1_Intron|MAK_ENST00000354489.2_Silent_p.L279L|MAK_ENST00000536370.1_3'UTR			P20794	MAK_HUMAN	male germ cell-associated kinase	279	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)	22	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				ATGGGTGTTTCAATGCCTATA	0.373000													15	63					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73169046	73169046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:73169046G>A	ENST00000545377.1	+	22	2965	c.2789G>A	c.(2788-2790)cGa>cAa	p.R930Q	ARHGEF28_ENST00000296794.6_Missense_Mutation_p.R930Q|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.R617Q|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.R930Q|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.R930Q|ARHGEF28_ENST00000426542.2_Missense_Mutation_p.R930Q|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.R930Q	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		GTGATCGACCGAATTGGAGAT	0.413000													6	18					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76924069	76924069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76924069C>T	ENST00000409709.3	+	47	6699	c.6427C>T	c.(6427-6429)Ccc>Tcc	p.P2143S	MYO7A_ENST00000409619.2_Missense_Mutation_p.P2094S|MYO7A_ENST00000458637.2_Missense_Mutation_p.P2103S|MYO7A_ENST00000605744.1_3'UTR	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	2143	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CCTCATCGATCCCAAAACGAA	0.527000													7	5					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97185297	97185297	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97185297T>C	ENST00000514100.1	+	4	283	c.41T>C	c.(40-42)cTt>cCt	p.L14P	EPHA6_ENST00000502694.1_Missense_Mutation_p.L14P|EPHA6_ENST00000389672.5_Intron|EPHA6_ENST00000442602.2_Intron	NM_001278300.1	NP_001265229.1	Q9UF33	EPHA6_HUMAN	EPH receptor A6	0						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						ctgtactggcttaatgaaaag	0.428000													12	89					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89854483	89854483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:89854483G>A	ENST00000287908.3	+	2	480	c.87G>A	c.(85-87)agG>agA	p.R29R	STEAP2_ENST00000402625.2_Silent_p.R29R|STEAP2_ENST00000394622.2_Silent_p.R29R|STEAP2_ENST00000394626.1_Silent_p.R29R|STEAP2_ENST00000394632.1_Silent_p.R29R|STEAP2_ENST00000394629.2_Silent_p.R29R|STEAP2_ENST00000394621.2_Silent_p.R29R	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	29					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					AAGATGCAAGGAAGGTCACTG	0.408000													35	125					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133805017	133805017	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133805017C>T	ENST00000372338.4	-	2	731	c.489G>A	c.(487-489)aaG>aaA	p.K163K	FIBCD1_ENST00000253018.4_Silent_p.K5K|FIBCD1_ENST00000448616.1_Silent_p.K163K|FIBCD1_ENST00000372337.2_Silent_p.K5K	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	163					signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		TGCCATGCCCCTTCCGCAGCC	0.701000													5	25					0	0	1	0	0
RNASE10	338879	broad.mit.edu	37	14	20978633	20978633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20978633G>A	ENST00000430083.1	+	2	491	c.87G>A	c.(85-87)atG>atA	p.M29I	RNASE10_ENST00000328444.5_Start_Codon_SNP_p.M1I			Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	1						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	12	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		CAGGCAAAATGAAGCTGAATC	0.488000													37	109					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124731866	124731866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124731866G>A	ENST00000311127.4	-	6	2624	c.2557C>T	c.(2557-2559)Ctt>Ttt	p.L853F		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	853						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						GTGGTCATAAGAGGCTGAGAG	0.517000													29	156					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67053666	67053666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:67053666G>A	ENST00000295568.4	+	3	328	c.197G>A	c.(196-198)cGa>cAa	p.R66Q	KBTBD8_ENST00000469661.1_Intron|KBTBD8_ENST00000417314.2_Missense_Mutation_p.R92Q|KBTBD8_ENST00000460576.1_Intron	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	92	BTB.									breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		AAAGAAGTTCGAATAGTTGGT	0.373000													66	144					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17809054	17809054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17809054G>A	ENST00000378814.5	-	18	2107	c.2108C>T	c.(2107-2109)aCc>aTc	p.T703I	KIF13A_ENST00000378843.2_Missense_Mutation_p.T703I|KIF13A_ENST00000259711.6_Missense_Mutation_p.T703I|KIF13A_ENST00000378826.2_Missense_Mutation_p.T703I|KIF13A_ENST00000378816.5_Missense_Mutation_p.T703I	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	703					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTGGTAATCGGTGAGTTTGCT	0.473000													11	29					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30794044	30794044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30794044G>A	ENST00000262525.4	-	3	1812	c.1605C>T	c.(1603-1605)atC>atT	p.I535I		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			CCCTCTCATGGATCACCCGGT	0.697000													7	16					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55968569	55968569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55968569G>A	ENST00000263923.4	-	14	2389	c.2094C>T	c.(2092-2094)atC>atT	p.I698I		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	698	Ig-like C2-type 7.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TAAACCACATGATCTGTGGAG	0.458000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			51	85					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1585101	1585101	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1585101G>A	ENST00000381297.4	-	2	561	c.351C>T	c.(349-351)atC>atT	p.I117I		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	117						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCTCCACGCTGATACAGGTCA	0.632000			T	CRLF2	"""B-ALL, Downs associated ALL"""								6	18					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100451918	100451918	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100451918A>T	ENST00000279907.7	-	14	3349	c.3137T>A	c.(3136-3138)aTc>aAc	p.I1046N	UHRF1BP1L_ENST00000545232.2_Missense_Mutation_p.I696N	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1046										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						AGCTTTAAAGATGGACTCTAT	0.358000													30	81					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49831551	49831551	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49831551G>A	ENST00000527477.1	+	0	1776																											CAATATATATGGAGAGGAGGG	0.453000													24	28					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187447255	187447255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:187447255G>A	ENST00000406870.2	-	5	1304	c.938C>T	c.(937-939)gCc>gTc	p.A313V	RP11-211G3.3_ENST00000437407.1_Intron|BCL6_ENST00000232014.4_Missense_Mutation_p.A313V|RP11-211G3.3_ENST00000449623.1_Intron|BCL6_ENST00000450123.2_Missense_Mutation_p.A313V	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	313					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GAAATGCAGGGCAATCTCATC	0.592000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								44	104					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904976	73904976	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73904976G>T	ENST00000342056.2	+	15	3093	c.2695G>T	c.(2695-2697)Gag>Tag	p.E899*	KCNQ5_ENST00000355635.3_Nonsense_Mutation_p.E881*|KCNQ5_ENST00000355194.4_Nonsense_Mutation_p.E880*|KCNQ5_ENST00000370398.1_Nonsense_Mutation_p.E880*|KCNQ5_ENST00000414165.2_Nonsense_Mutation_p.E770*|KCNQ5_ENST00000403813.2_Nonsense_Mutation_p.E871*|KCNQ5_ENST00000402622.2_Nonsense_Mutation_p.E890*	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	880					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GGGTCCCGAAGAGACAGAGAC	0.507000													8	132					0.000274275	0.000274633	1	1	0
CCDC136	64753	broad.mit.edu	37	7	128445896	128445896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128445896G>A	ENST00000297788.4	+	7	1397	c.1030G>A	c.(1030-1032)Gag>Aag	p.E344K	CCDC136_ENST00000378685.4_Missense_Mutation_p.E382K|CCDC136_ENST00000487361.1_Missense_Mutation_p.E344K|CCDC136_ENST00000464832.1_Missense_Mutation_p.E394K	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	344						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GCTGCAGAGGGAGCTCAAGTG	0.562000													15	28					0	0	1	0	0
TRAF1	7185	broad.mit.edu	37	9	123671621	123671621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123671621G>A	ENST00000373887.3	-	7	3364	c.919C>T	c.(919-921)Ctg>Ttg	p.L307L	TRAF1_ENST00000540010.1_Silent_p.L307L|TRAF1_ENST00000546084.1_Silent_p.L185L	NM_005658.4	NP_005649.1	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	307	MATH.				apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(4)|pancreas(1)|skin(2)	22						TACAGCCGCAGGCACAACTTG	0.547000													26	198					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	56989552	56989552	+	Splice_Site	SNP	C	C	T	rs1802023		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:56989552C>T	ENST00000371250.3	-	4	1127	c.575_splice	c.e4-1	p.R192_splice		NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	192					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						AGAAGGACTTCCTGCAAGAGC	0.502000													10	22					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230916267	230916267	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230916267C>T	ENST00000354537.1	+	10	1298	c.1216C>T	c.(1216-1218)Ctg>Ttg	p.L406L	RP11-99J16__A.2_ENST00000452640.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA|CAPN9_ENST00000366666.2_Silent_p.L369L|RP11-99J16__A.2_ENST00000428480.1_RNA|CAPN9_ENST00000271971.2_Silent_p.L432L	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	432	Domain III.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				AGACGAACACCTGAACAAAGA	0.522000													36	99					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130292832	130292832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130292832C>T	ENST00000358511.6	+	7	3041	c.3010C>T	c.(3010-3012)Ctt>Ttt	p.L1004F	COL6A6_ENST00000453409.2_Missense_Mutation_p.L1004F	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1004	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCTTGTTTTCCTTATGGATGG	0.363000													11	33					0	0	1	0	0
TRBV7-3	28595	broad.mit.edu	37	7	142247209	142247209	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142247209G>A	ENST00000390361.3	-	0	296																											GCAAAGAACCGATCGTTGGGC	0.572000													38	99					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59166535	59166535	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:59166535G>A	ENST00000262717.4	+	3	761	c.363G>A	c.(361-363)agG>agA	p.R121R	CDH20_ENST00000536675.2_Silent_p.R121R|CDH20_ENST00000538374.1_Silent_p.R121R			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	121	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				CCATTCAGAGGCTCGACCGAG	0.552000													13	20					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194117702	194117702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:194117702C>T	ENST00000401815.1	-	1	1381	c.1310G>A	c.(1309-1311)cGg>cAg	p.R437Q	GP5_ENST00000323007.3_Missense_Mutation_p.R437Q			P40197	GPV_HUMAN	glycoprotein V (platelet)	437	LRRCT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		TAGGTGCTGCCGCAGCCACCC	0.756000													7	1					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43625191	43625191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43625191G>A	ENST00000405006.4	-	29	4497	c.4146C>T	c.(4144-4146)acC>acT	p.T1382T	THADA_ENST00000330266.7_Intron|THADA_ENST00000485353.1_5'UTR|THADA_ENST00000415080.2_Silent_p.T1063T|THADA_ENST00000405975.2_Silent_p.T1382T	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1382							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GAGTTCGAATGGTATTAGGAA	0.483000													50	72					0	0	1	0	0
TYR	7299	broad.mit.edu	37	11	89028445	89028445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:89028445C>T	ENST00000263321.5	+	5	2003	c.1501C>T	c.(1501-1503)Cgt>Tgt	p.R501C		NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	501					eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CTTGCTGTGTCGTCACAAGAG	0.537000													19	46					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174326	150174326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150174326G>A	ENST00000307271.3	+	5	2030	c.1456G>A	c.(1456-1458)Gga>Aga	p.G486R		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	486						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding	p.G486R(1)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GACATGGGACGGACAGGAGGT	0.597000													24	37					0	0	1	0	0
IL1RN	3557	broad.mit.edu	37	2	113890437	113890437	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113890437G>A	ENST00000361779.3	+	6	766	c.421G>A	c.(421-423)Gag>Aag	p.E141K	IL1RN_ENST00000409930.3_Missense_Mutation_p.E175K|IL1RN_ENST00000409052.1_Missense_Mutation_p.E141K|IL1RN_ENST00000354115.2_Missense_Mutation_p.E157K|IL1RN_ENST00000259206.5_Missense_Mutation_p.E178K	NM_173843.2	NP_776215.1	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist	175					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	10					Anakinra(DB00026)	CTACTTCCAGGAGGACGAGTA	0.612000									Lichen Sclerosis et Atrophicus, Familial Clustering of				11	99					0	0	1	0	0
SNRPB	6628	broad.mit.edu	37	20	2443865	2443865	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2443865G>A	ENST00000339610.6	-	6	647	c.192C>T	c.(190-192)acC>acT	p.T64T	SNRPB_ENST00000438552.2_Silent_p.T143T|SNRPB_ENST00000381342.2_Silent_p.T143T			P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	143					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						TTCCTTGTGGGGTCATCACCT	0.562000													15	41					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57317578	57317578	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57317578A>T	ENST00000457912.1	+	8	1532	c.1532A>T	c.(1531-1533)aAg>aTg	p.K511M	SMTNL1_ENST00000399154.2_Missense_Mutation_p.K456M|SMTNL1_ENST00000527972.1_Missense_Mutation_p.K493M			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	493										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						AAGACCAAGAAGAAGTGAGGA	0.602000													8	16					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215301468	215301468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215301468C>T	ENST00000312504.5	+	3	1308	c.506C>T	c.(505-507)cCt>cTt	p.P169L	AC107218.3_ENST00000437883.1_RNA|AC107218.3_ENST00000412896.1_RNA|VWC2L_ENST00000427124.1_Intron	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	169	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						CAATGTTGTCCTGTCTGCAAA	0.453000													14	31					0	0	1	0	0
SART3	9733	broad.mit.edu	37	12	108919967	108919967	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108919967A>G	ENST00000228284.3	-	16	2513	c.2279T>C	c.(2278-2280)cTt>cCt	p.L760P	SART3_ENST00000431469.2_Missense_Mutation_p.L724P	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	760	RRM 1.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						CAGTGCCTGAAGGGCTGATTT	0.507000									Porokeratosis				16	139					0	0	1	0	0
RBBP8NL	140893	broad.mit.edu	37	20	60987918	60987918	+	Missense_Mutation	SNP	C	C	T	rs145375194	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60987918C>T	ENST00000252998.1	-	12	1870	c.1714G>A	c.(1714-1716)Gaa>Aaa	p.E572K		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		TCATCCAGTTCGTCGGACTCT	0.652000													29	74					0	0	1	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208773295	208773295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:208773295G>A	ENST00000457206.1	-	7	2364	c.1937C>T	c.(1936-1938)tCc>tTc	p.S646F	PLEKHM3_ENST00000389247.4_Silent_p.F631F|PLEKHM3_ENST00000427836.2_Silent_p.F631F			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	0					intracellular signal transduction		metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATTCTCTGGGGAAAATTCTGA	0.438000													24	62					0	0	1	0	0
KRT222	125113	broad.mit.edu	37	17	38818217	38818217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38818217C>T	ENST00000476049.1	-	2	217	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	KRT222_ENST00000394052.3_Missense_Mutation_p.R59Q			Q8N1A0	KT222_HUMAN	keratin 222	59						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(2)|skin(1)	15						CCACTGGCGTCGGGCCTCCTT	0.468000													92	116					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16878310	16878310	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:16878310C>T	ENST00000377833.4	-	63	10169	c.10104G>A	c.(10102-10104)atG>atA	p.M3368I		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3368	CUB 25.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGCAGTACTCATAGAAGAAT	0.403000													35	67					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3151807	3151807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3151807C>T	ENST00000262958.3	+	4	846	c.588C>T	c.(586-588)tgC>tgT	p.C196C	AC005264.2_ENST00000587587.1_RNA	NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	196					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		ACGAGTACTGCTTCTCCGTGC	0.647000													9	110					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45706897	45706897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45706897C>T	ENST00000291582.5	+	3	471	c.344C>T	c.(343-345)cCc>cTc	p.P115L		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	115					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		GGGAGGAAGCCCCCGGCCGTC	0.677000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				23	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179528772	179528772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179528772G>A	ENST00000589042.1	-	169	36558	c.36334C>T	c.(36334-36336)Cct>Tct	p.P12112S	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10261	Ig-like 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTTTTTAGGAGGCACCACC	0.388000													45	96					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47264840	47264840	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47264840C>T	ENST00000271153.4	+	1	123	c.87C>T	c.(85-87)ctC>ctT	p.L29L	CYP4B1_ENST00000371923.4_Silent_p.L29L|CYP4B1_ENST00000546128.1_Intron|CYP4B1_ENST00000371919.4_Silent_p.L29L			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	29					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TTCTCAAGCTCATCCACCTGC	0.577000													8	18					0	0	1	0	0
CELF5	60680	broad.mit.edu	37	19	3284932	3284932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3284932C>T	ENST00000541430.2	+	9	1033	c.997C>T	c.(997-999)Cct>Tct	p.P333S	CELF5_ENST00000292672.2_Missense_Mutation_p.P358S|CELF5_ENST00000588101.1_3'UTR	NM_001172673.1	NP_001166144.1	Q8N6W0	CELF5_HUMAN	CUGBP, Elav-like family member 5	358					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)	13						GACACTGCATCCTGCCTTCTC	0.711000													3	21					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12760765	12760765	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12760765G>A	ENST00000456935.2	-	18	2269	c.2229C>T	c.(2227-2229)ttC>ttT	p.F743F	MAN2B1_ENST00000221363.4_Silent_p.F742F	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	743					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TGTCTGTGTAGAAGCGTCCCT	0.607000													65	156					0	0	1	0	0
E2F7	144455	broad.mit.edu	37	12	77419463	77419463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:77419463G>A	ENST00000322886.7	-	12	2675	c.2440C>T	c.(2440-2442)Cct>Tct	p.P814S	E2F7_ENST00000416496.2_Intron	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	814					cell cycle	transcription factor complex	DNA binding|identical protein binding	p.P814S(2)		central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						TGAAGCTGAGGGTCTGCAGAA	0.537000													37	61					0	0	1	0	0
PLEKHN1	84069	broad.mit.edu	37	1	907761	907761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:907761G>A	ENST00000379409.2	+	9	1145	c.1115G>A	c.(1114-1116)gGg>gAg	p.G372E	PLEKHN1_ENST00000379407.2_Missense_Mutation_p.G332E|PLEKHN1_ENST00000379410.3_Missense_Mutation_p.G320E			Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N member 1	372										central_nervous_system(1)|endometrium(3)|kidney(1)|lung(2)|skin(1)|urinary_tract(1)	9	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CACAGGGAGGGGGCCCCGCCG	0.672000													7	3					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68649559	68649559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68649559C>T	ENST00000423218.2	-	7	774	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	ITGA11_ENST00000315757.7_Missense_Mutation_p.E227K|ITGA11_ENST00000562826.1_5'UTR			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	227	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	CTGGCAGCTTCCACCACATCT	0.468000													39	46					0	0	1	0	0
FGF5	2250	broad.mit.edu	37	4	81207505	81207505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:81207505C>T	ENST00000312465.7	+	3	712	c.486C>T	c.(484-486)ttC>ttT	p.F162F	FGF5_ENST00000503413.1_3'UTR|FGF5_ENST00000456523.3_3'UTR	NM_004464.3	NP_004455.2	P12034	FGF5_HUMAN	fibroblast growth factor 5	162					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22						ACTGCAAGTTCAGGGAGCGTT	0.393000													34	183					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94718186	94718186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94718186C>T	ENST00000304338.3	+	16	1972	c.1818C>T	c.(1816-1818)ttC>ttT	p.F606F		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	606						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GTAAATATTTCTTTCTACCTG	0.289000													24	53					0	0	1	0	0
C7orf34	135927	broad.mit.edu	37	7	142636722	142636722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142636722C>T	ENST00000409607.3	+	1	120	c.79C>T	c.(79-81)Cct>Tct	p.P27S		NM_178829.4	NP_849151.2	Q96L11	CG034_HUMAN	chromosome 7 open reading frame 34	2						extracellular region				large_intestine(1)|lung(4)	5	Melanoma(164;0.059)					CAGGTCCATGCCTCCCCTGGC	0.657000													13	51					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103444967	103444967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103444967G>A	ENST00000358392.2	-	32	2934	c.2617C>T	c.(2617-2619)Cca>Tca	p.P873S	COL11A1_ENST00000512756.1_Missense_Mutation_p.P745S|COL11A1_ENST00000353414.4_Missense_Mutation_p.P822S|COL11A1_ENST00000370096.3_Missense_Mutation_p.P861S	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	861	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGGCACCTGGAAACCCAGGG	0.353000													17	37					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100169943	100169943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100169943C>T	ENST00000524871.1	+	20	2725	c.2435C>T	c.(2434-2436)gCt>gTt	p.A812V	CNTN5_ENST00000527185.1_Missense_Mutation_p.A812V|CNTN5_ENST00000528682.1_Missense_Mutation_p.A812V|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Missense_Mutation_p.A812V|CNTN5_ENST00000418526.2_Missense_Mutation_p.A738V	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	812	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TATATTGTGGCTTTCAGACCC	0.378000													12	31					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	21556024	21556024	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:21556024G>A	ENST00000298925.5	+	17	1987	c.1834G>A	c.(1834-1836)Gat>Aat	p.D612N	NELL1_ENST00000357134.5_Missense_Mutation_p.D584N|NELL1_ENST00000325319.5_Missense_Mutation_p.D527N|NELL1_ENST00000529218.1_3'UTR|NELL1_ENST00000532434.1_Intron			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	584	EGF-like 6; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity	p.D584N(1)		NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						TTTCCATGACGATGGGACCTA	0.532000													6	76					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46307639	46307639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46307639C>T	ENST00000357422.2	+	4	1533	c.990C>T	c.(988-990)ttC>ttT	p.F330F	CCR3_ENST00000395942.2_Silent_p.F330F|CCR3_ENST00000545097.1_Silent_p.F351F|CCR3_ENST00000541018.1_Silent_p.F330F|CCR3_ENST00000395940.2_Silent_p.F330F			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	330					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		ACATCCCATTCCTTCCTAGTG	0.512000													7	60					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468954	56468954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:56468954C>T	ENST00000288221.6	-	2	337	c.82G>A	c.(82-84)Ggc>Agc	p.G28S		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	28						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CTTCGGTGGCCCAAACGAGGA	0.498000													20	57					0	0	1	0	0
GGA2	23062	broad.mit.edu	37	16	23492068	23492068	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23492068G>A	ENST00000309859.4	-	10	986	c.904C>T	c.(904-906)Ctc>Ttc	p.L302F	GGA2_ENST00000567468.1_Intron	NM_015044.4	NP_055859.1	Q9UJY4	GGA2_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	302	GAT.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(48;0.0386)		TGGGTGAGGAGGTCATTTGCC	0.498000													28	56					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	92027138	92027138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92027138C>T	ENST00000265742.3	+	19	2873	c.2497C>T	c.(2497-2499)Cct>Tct	p.P833S		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	833							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGACTACACCCCTGCCAGTCG	0.542000													67	186					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141660725	141660725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141660725G>A	ENST00000389484.3	-	23	4501	c.3530C>T	c.(3529-3531)tCg>tTg	p.S1177L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1177					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTGTTCAGCGAACACTCATC	0.393000										TSP Lung(27;0.18)			28	51					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156828383	156828383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156828383C>T	ENST00000368195.3	-	1	427	c.31G>A	c.(31-33)Gca>Aca	p.A11T	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	11					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGCAGGCATGCTCCCCAGGGC	0.617000													30	80					0	0	1	0	0
TPCN2	219931	broad.mit.edu	37	11	68839451	68839451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68839451C>T	ENST00000294309.3	+	11	1122	c.1021C>T	c.(1021-1023)Cta>Tta	p.L341L	TPCN2_ENST00000542467.1_Silent_p.L341L|TPCN2_ENST00000442692.2_3'UTR	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	341					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTTTGAAGTCCTATCCTCCAT	0.627000													27	94					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4247875	4247875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4247875G>A	ENST00000399609.3	-	4	313	c.301C>T	c.(301-303)Ccg>Tcg	p.P101S	SRL_ENST00000537996.1_Missense_Mutation_p.P59S	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	560	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						ACACTCCACGGTCCCAGGAAC	0.423000													27	45					0	0	1	0	0
IP6K3	117283	broad.mit.edu	37	6	33695869	33695869	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33695869C>T	ENST00000451316.1	-	4	943	c.408G>A	c.(406-408)aaG>aaA	p.K136K	IP6K3_ENST00000293756.4_Silent_p.K136K	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	136					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						CTCACCTCTCCTTGGGTGAGC	0.652000													11	27					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140396114	140396114	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140396114C>T	ENST00000406427.1	-	15	1875	c.1539G>A	c.(1537-1539)agG>agA	p.R513R	PNPLA7_ENST00000371457.1_Silent_p.R94R|PNPLA7_ENST00000277531.4_Silent_p.R488R	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	488					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GGTCTCCCTGCCTTGACACCA	0.637000													4	29					0	0	1	0	0
OR2W5	441932	broad.mit.edu	37	1	247654918	247654918	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247654918G>A	ENST00000522351.1	+	0	549							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GTCCTCAGACGATGCAGCTCT	0.557000													31	61					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85906067	85906067	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:85906067G>A	ENST00000373131.1	+	3	793	c.630G>A	c.(628-630)gcG>gcA	p.A210A	DACH2_ENST00000508860.1_Silent_p.A56A|DACH2_ENST00000373125.4_Silent_p.A223A|DACH2_ENST00000510272.1_Silent_p.A4A	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TGGCTGAGGCGATGAAACTTC	0.358000													16	5					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919910	4919910	+	Missense_Mutation	SNP	C	C	T	rs149897413		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4919910C>T	ENST00000433855.1	+	1	1569	c.703C>T	c.(703-705)Cat>Tat	p.H235Y	KCNA6_ENST00000280684.3_Missense_Mutation_p.H235Y	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	235						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.H235Y(1)		NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CTACACATTTCATCATGGCAT	0.552000										HNSCC(72;0.22)			28	118					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58118073	58118073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58118073C>T	ENST00000332854.6	+	3	1400	c.1180C>T	c.(1180-1182)Ctt>Ttt	p.L394F	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CAATATCTACCTTATTCACCA	0.423000													46	98					0	0	1	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198523	91198523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:91198523G>A	ENST00000341233.4	-	6	1166	c.776C>T	c.(775-777)tCc>tTc	p.S259F	SLC16A12_ENST00000371790.4_Missense_Mutation_p.S289F	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	259						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						AAACAGAACGGAGACGGCTAA	0.448000													25	55					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280073	152280073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152280073C>T	ENST00000368799.1	-	3	7324	c.7289G>A	c.(7288-7290)cGg>cAg	p.R2430Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2430	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGTCCCGGTCCGTCCATGGGC	0.587000									Ichthyosis				95	363					0	0	1	0	0
SEPT9	10801	broad.mit.edu	37	17	75398191	75398191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:75398191C>T	ENST00000329047.8	+	2	885	c.73C>T	c.(73-75)Cca>Tca	p.P25S	SEPT9_ENST00000427177.1_Missense_Mutation_p.P43S|SEPT9_ENST00000449803.2_5'UTR|SEPT9_ENST00000592420.1_5'UTR|SEPT9_ENST00000590294.1_Missense_Mutation_p.P25S|SEPT9_ENST00000591198.1_Missense_Mutation_p.P24S|SEPT9_ENST00000427674.2_5'UTR|SEPT9_ENST00000423034.2_Missense_Mutation_p.P36S|SEPT9_ENST00000431235.2_5'UTR|SEPT9_ENST00000588690.1_5'UTR	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	43					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			CAACTCCACCCCACCCCGGAG	0.567000													19	49					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769386	247769386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247769386C>T	ENST00000320002.2	+	1	531	c.499C>T	c.(499-501)Cct>Tct	p.P167S	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTTGCAATTGCCTCTCTGTGG	0.473000													37	80					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61568368	61568368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61568368C>T	ENST00000577647.1	+	7	1018	c.973C>T	c.(973-975)Cct>Tct	p.P325S	ACE_ENST00000290863.6_Missense_Mutation_p.P325S|ACE_ENST00000413513.3_Missense_Mutation_p.P325S|ACE_ENST00000290866.4_Missense_Mutation_p.P899S|ACE_ENST00000490216.2_Missense_Mutation_p.P325S|ACE_ENST00000428043.1_Missense_Mutation_p.P899S|ACE_ENST00000421982.2_Missense_Mutation_p.P145S			P12821	ACE_HUMAN	angiotensin I converting enzyme	899	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGTGCCCTTCCCTTCAGCCCC	0.617000													42	127					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46306935	46306935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46306935G>A	ENST00000357422.2	+	4	829	c.286G>A	c.(286-288)Ggg>Agg	p.G96R	CCR3_ENST00000395942.2_Missense_Mutation_p.G96R|CCR3_ENST00000545097.1_Missense_Mutation_p.G117R|CCR3_ENST00000541018.1_Missense_Mutation_p.G96R|CCR3_ENST00000395940.2_Missense_Mutation_p.G96R			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	96					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CTATGTCAGGGGGCATAACTG	0.493000													87	217					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25430789	25430789	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25430789G>A	ENST00000424208.1	+	0	582				SNORD115-9_ENST00000362912.1_RNA	NR_003305.1																						GGTCGATGATGAGAACCTTAT	0.493000													89	223					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78647111	78647111	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:78647111G>A	ENST00000286627.5	-	27	4402	c.3450C>T	c.(3448-3450)tcC>tcT	p.S1150S	KCNMA1_ENST00000372440.1_Silent_p.S1150S|KCNMA1_ENST00000354353.5_Silent_p.S1211S|KCNMA1_ENST00000404857.1_Silent_p.S1191S|KCNMA1_ENST00000406533.3_Silent_p.S1212S|KCNMA1_ENST00000286628.8_Silent_p.S1208S|KCNMA1_ENST00000404771.3_Silent_p.S1208S|KCNMA1_ENST00000372443.1_Silent_p.S1177S	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	1208					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGGATGGGATGGAGTGAACAG	0.572000													25	131					0	0	1	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47650692	47650692	+	Missense_Mutation	SNP	G	G	A	rs150391778		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47650692G>A	ENST00000294338.2	-	3	376	c.254C>T	c.(253-255)tCg>tTg	p.S85L	PDZK1IP1_ENST00000371885.1_Missense_Mutation_p.S85L|PDZK1IP1_ENST00000491793.1_5'UTR	NM_005764.3	NP_005755.1	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	85						integral to membrane				endometrium(1)|lung(1)|prostate(1)	3						GGCCGCCATCGAAGAGTACCT	0.602000													22	57					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833573	168833573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168833573G>A	ENST00000464456.1	-	7	2723	c.1523C>T	c.(1522-1524)cCc>cTc	p.P508L	MECOM_ENST00000433243.2_Missense_Mutation_p.P509L|MECOM_ENST00000472280.1_Missense_Mutation_p.P509L|MECOM_ENST00000392736.3_Missense_Mutation_p.P508L|MECOM_ENST00000494292.1_Missense_Mutation_p.P696L|MECOM_ENST00000468789.1_Missense_Mutation_p.P508L|MECOM_ENST00000264674.3_Missense_Mutation_p.P573L|MECOM_ENST00000460814.1_Missense_Mutation_p.P508L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						AAATGGGAGGGGAAACATGGA	0.423000													21	102					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32724803	32724803	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:32724803C>T	ENST00000421745.2	+	46	8792	c.8658C>T	c.(8656-8658)tcC>tcT	p.S2886S		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2886					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CAGATAGCTCCGTGGGTGCTC	0.438000													68	199					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71891540	71891540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71891540C>T	ENST00000258104.3	+	45	5306	c.5029C>T	c.(5029-5031)Cgc>Tgc	p.R1677C	DYSF_ENST00000410041.1_Missense_Mutation_p.R1695C|DYSF_ENST00000429174.2_Missense_Mutation_p.R1698C|DYSF_ENST00000409744.1_Missense_Mutation_p.R1685C|DYSF_ENST00000410020.3_Missense_Mutation_p.R1716C|DYSF_ENST00000394120.2_Missense_Mutation_p.R1678C|DYSF_ENST00000409366.1_Missense_Mutation_p.R1699C|DYSF_ENST00000409582.3_Missense_Mutation_p.R1715C|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Missense_Mutation_p.R1708C|DYSF_ENST00000409651.1_Missense_Mutation_p.R1709C|DYSF_ENST00000409762.1_Missense_Mutation_p.R1694C	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1677						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GTTTGGGGCTCGCTGTGGACT	0.552000													22	45					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149509363	149509363	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149509363G>A	ENST00000378016.2	+	0	9761							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGAGCTGGGGGATGGGGTCCA	0.701000													4	22					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891498	5891498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:5891498C>T	ENST00000581347.1	-	3	1210	c.565G>A	c.(565-567)Gag>Aag	p.E189K	TMEM200C_ENST00000383490.2_Missense_Mutation_p.E189K|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	189						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						TCCCGGTTCTCGTGGAGGACC	0.602000													7	14					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45396248	45396248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45396248G>A	ENST00000389039.6	-	20	2949	c.2564C>T	c.(2563-2565)tCc>tTc	p.S855F	DUOX2_ENST00000603300.1_Missense_Mutation_p.S855F			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	855	EF-hand 2.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ATCCTCTGGGGAGCCTGGGAA	0.512000													12	33					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100585734	100585734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100585734C>T	ENST00000471714.1	-	10	1107	c.998G>A	c.(997-999)cGa>cAa	p.R333Q	ABI3BP_ENST00000495063.1_Missense_Mutation_p.R333Q|ABI3BP_ENST00000284322.5_Missense_Mutation_p.R333Q			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	333						extracellular space		p.R333Q(2)		central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TGTTGTGGGTCGTGCTGAGAT	0.358000													16	40					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55139809	55139809	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55139809C>T	ENST00000257290.5	+	10	1801	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	490	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTGTGACTTTCGCCAAAGTGG	0.532000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			6	105					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140846790	140846790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140846790C>T	ENST00000371372.1	+	7	1176	c.1031C>T	c.(1030-1032)tCc>tTc	p.S344F	CACNA1B_ENST00000371357.1_Missense_Mutation_p.S344F|CACNA1B_ENST00000371363.1_Missense_Mutation_p.S344F|CACNA1B_ENST00000277551.2_Missense_Mutation_p.S344F|CACNA1B_ENST00000371355.4_Missense_Mutation_p.S344F|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	344					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	ATCATCGGCTCCTTCTTCATG	0.582000													7	60					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5436224	5436224	+	Missense_Mutation	SNP	G	G	A	rs149973177		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:5436224G>A	ENST00000345221.3	-	11	3768	c.3214C>T	c.(3214-3216)Cct>Tct	p.P1072S	NLRP1_ENST00000262467.5_Missense_Mutation_p.P1076S|NLRP1_ENST00000577119.1_Missense_Mutation_p.P1042S|NLRP1_ENST00000572272.1_Missense_Mutation_p.P1072S|NLRP1_ENST00000269280.4_Missense_Mutation_p.P1072S|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000354411.3_Missense_Mutation_p.P1042S	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	1072					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding	p.P1072S(2)|p.P1076S(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GTCCCCAAAGGCTTCGTATGC	0.577000													7	49					0	0	1	0	0
BHMT	635	broad.mit.edu	37	5	78411722	78411722	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78411722G>A	ENST00000274353.5	+	2	273	c.166_splice	c.e2+1	p.V56_splice	DMGDH_ENST00000520388.1_Intron|BHMT_ENST00000524080.1_Splice_Site_p.G56_splice	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	56	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	CCCAGAAGCAGGTTGGTGCAG	0.547000													11	54					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23428365	23428365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23428365G>A	ENST00000307149.5	-	9	1400	c.1215C>T	c.(1213-1215)gcC>gcT	p.A405A		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	405					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		ATCTGTCAACGGCTGCAGACG	0.562000													13	50					0	0	1	0	0
TSPAN9	10867	broad.mit.edu	37	12	3387589	3387589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:3387589C>T	ENST00000011898.5	+	4	227	c.66C>T	c.(64-66)ctC>ctT	p.L22L	TSPAN9_ENST00000407263.1_Silent_p.L22L|TSPAN9_ENST00000492305.1_3'UTR|TSPAN9_ENST00000537971.1_Silent_p.L22L	NM_006675.4	NP_006666.1	O75954	TSN9_HUMAN	tetraspanin 9	22						integral to plasma membrane|membrane fraction				endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			CTTTCCAGCTCTGTGGCTGTG	0.602000													42	116					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50204093	50204093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50204093C>T	ENST00000392518.4	+	5	806	c.434C>T	c.(433-435)tCc>tTc	p.S145F	CPT1C_ENST00000405931.2_Missense_Mutation_p.S145F|CPT1C_ENST00000323446.5_Missense_Mutation_p.S145F|CPT1C_ENST00000354199.5_Missense_Mutation_p.S145F|CPT1C_ENST00000598293.1_Missense_Mutation_p.S145F	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	145					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GCCATGTCCTCCCCCACCAAG	0.622000													40	109					0	0	1	0	0
SLC22A15	55356	broad.mit.edu	37	1	116569584	116569584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:116569584C>T	ENST00000369503.4	+	5	799	c.669C>T	c.(667-669)tcC>tcT	p.S223S	SLC22A15_ENST00000369502.1_Silent_p.S223S	NM_018420.2	NP_060890.2	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	223					ion transport	integral to membrane	transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|urinary_tract(1)	17	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TCATCCGCTCCTGGAGGACCC	0.448000													60	123					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021043	132021043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132021043G>A	ENST00000356920.5	+	15	2109	c.2015G>A	c.(2014-2016)aGa>aAa	p.R672K	PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	672							ATP binding										AGCCAGCTAAGAGAAAAGAAA	0.363000													6	45					0	0	1	0	0
RHOF	54509	broad.mit.edu	37	12	122218831	122218831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122218831C>T	ENST00000267205.2	-	4	1046	c.418G>A	c.(418-420)Gag>Aag	p.E140K	TMEM120B_ENST00000449592.2_3'UTR|TMEM120B_ENST00000538055.1_Intron	NM_019034.2	NP_061907.2	Q9HBH0	RHOF_HUMAN	ras homolog family member F (in filopodia)	140					actin filament organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity			large_intestine(1)|lung(1)|ovary(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;4.38e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.223)		CGCAGCTGCTCCTTGTCCTTC	0.662000													11	25					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48139140	48139140	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48139140G>A	ENST00000311303.3	-	19	2928	c.2583C>T	c.(2581-2583)ttC>ttT	p.F861F	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_Silent_p.F858F	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	861	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				ACACCAGCATGAACACCATGC	0.572000													27	58					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121430236	121430236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121430236C>T	ENST00000260197.7	+	21	3048	c.2919C>T	c.(2917-2919)atC>atT	p.I973I		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	973					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGAATGAAATCTACTGGGATG	0.478000													25	81					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70917961	70917961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70917961G>A	ENST00000264436.3	-	8	1250	c.806C>T	c.(805-807)gCc>gTc	p.A269V	ADD2_ENST00000413157.2_Missense_Mutation_p.A269V|ADD2_ENST00000407644.2_Missense_Mutation_p.A269V|ADD2_ENST00000355733.3_Missense_Mutation_p.A269V|AC007395.3_ENST00000457851.1_RNA|ADD2_ENST00000430656.1_Missense_Mutation_p.A285V	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	269					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						GATCCGATCGGCTTCCTGCTC	0.537000													24	80					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23542422	23542422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23542422G>A	ENST00000300619.7	-	4	3564	c.3359C>T	c.(3358-3360)gCt>gTt	p.A1120V	ZNF91_ENST00000397082.2_Missense_Mutation_p.A1088V|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1120						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTTAGTAAGAGCTGAGGACTC	0.398000													15	93					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033513	82033513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82033513C>T	ENST00000328945.5	-	3	512	c.385G>A	c.(385-387)Gga>Aga	p.G129R	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	129					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						ACTTGACCTCCAAAGATGACA	0.488000													12	91					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176707784	176707784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176707784C>T	ENST00000439151.2	+	18	5886	c.5841C>T	c.(5839-5841)ttC>ttT	p.F1947F	NSD1_ENST00000347982.4_Silent_p.F1678F|NSD1_ENST00000361032.4_Silent_p.F1844F|NSD1_ENST00000354179.4_Silent_p.F1678F	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1947	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTGAAATTTTCCGCACATTAC	0.463000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			27	54					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89388756	89388756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89388756C>T	ENST00000439576.2	+	7	1446	c.1072C>T	c.(1072-1074)Cca>Tca	p.P358S	ACAN_ENST00000558207.1_Missense_Mutation_p.P358S|ACAN_ENST00000352105.7_Missense_Mutation_p.P358S|ACAN_ENST00000559004.1_Missense_Mutation_p.P358S|ACAN_ENST00000561243.1_Missense_Mutation_p.P358S	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	358					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGTGGACATCCCAGAAAACTT	0.577000													29	44					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100129237	100129237	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100129237C>T	ENST00000330710.5	+	6	1625	c.1527C>T	c.(1525-1527)aaC>aaT	p.N509N	HHIPL1_ENST00000357223.2_Silent_p.N509N	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	509					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				TCCAAGAGAACCCAGGGACAG	0.572000													8	51					0	0	1	0	0
GPR6	2830	broad.mit.edu	37	6	110300424	110300424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110300424G>A	ENST00000414000.2	+	3	393	c.154G>A	c.(154-156)Gga>Aga	p.G52R	GPR6_ENST00000275169.3_Missense_Mutation_p.G37R			P46095	GPR6_HUMAN	G protein-coupled receptor 6	37						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GGGCGAATGGGGACCCCCTGC	0.736000													16	29					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139657563	139657563	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139657563G>A	ENST00000263552.6	+	12	1360	c.822_splice	c.e12+1	p.E274_splice	TBXAS1_ENST00000448866.1_Splice_Site_p.E273_splice|TBXAS1_ENST00000436047.2_Splice_Site_p.E274_splice|TBXAS1_ENST00000414508.2_Splice_Site_p.E274_splice|TBXAS1_ENST00000416849.2_Splice_Site_p.E320_splice|TBXAS1_ENST00000425687.1_Splice_Site_p.E206_splice|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000411653.1_Splice_Site_p.E273_splice|TBXAS1_ENST00000458722.1_Splice_Site_p.E319_splice|TBXAS1_ENST00000336425.5_Splice_Site_p.E273_splice	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	273					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CTGCCGAAGAGGTAACGTATT	0.478000													6	58					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675180	81675180	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81675180C>T	ENST00000550584.2	-	26	3363	c.3068G>A	c.(3067-3069)tGg>tAg	p.W1023*	RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.W1023*|PPFIA2_ENST00000541570.2_Nonsense_Mutation_p.W559*|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.W1017*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.W1002*|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.W1008*|PPFIA2_ENST00000550359.2_Nonsense_Mutation_p.W870*|PPFIA2_ENST00000407050.4_Nonsense_Mutation_p.W922*|PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.W1008*|PPFIA2_ENST00000443686.3_Nonsense_Mutation_p.W918*|PPFIA2_ENST00000541017.1_Nonsense_Mutation_p.W209*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	922										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ATTTCCAATCCACTCATGATT	0.388000													27	88					0	0	1	0	0
TRIP13	9319	broad.mit.edu	37	5	893150	893150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:893150C>T	ENST00000166345.3	+	1	393	c.37C>T	c.(37-39)Ccc>Tcc	p.P13S		NM_004237.3	NP_004228.1	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	13					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	18			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			GCAGGCGCTTCCCTGTGTGGC	0.726000													6	8					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6730183	6730183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6730183G>A	ENST00000329858.4	-	2	988	c.232C>T	c.(232-234)Cgt>Tgt	p.R78C	LPAR5_ENST00000431922.1_Missense_Mutation_p.R78C|LPAR5_ENST00000540335.1_5'UTR	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	78						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						TAGGAGAGACGAACGGGCAGC	0.632000													8	20					0	0	1	0	0
MRPL1	65008	broad.mit.edu	37	4	78873665	78873665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:78873665C>T	ENST00000315567.8	+	9	1211	c.882C>T	c.(880-882)ttC>ttT	p.F294F		NM_020236.3	NP_064621.3	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1	294							RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)	17						TACGTGCTTTCCTTCGTAGTT	0.358000													32	77					0	0	1	0	0
SPRR2D	6703	broad.mit.edu	37	1	153012737	153012737	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153012737G>A	ENST00000368757.1	-	2	366	c.86C>T	c.(85-87)cCc>cTc	p.P29L	SPRR2D_ENST00000368758.3_Missense_Mutation_p.P29L|SPRR2D_ENST00000360379.3_Missense_Mutation_p.P29L|SPRR2D_ENST00000368756.1_Missense_Mutation_p.P29L			P22532	SPR2D_HUMAN	small proline-rich protein 2D	29	3 X 9 AA tandem repeats of P-K-C-P-[EQ]- P-C-P-[PS].				keratinization	cornified envelope|cytoplasm				endometrium(1)|skin(1)	2	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCACTTCGGGGGTGGACATGG	0.612000													68	123					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228525050	228525050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228525050C>T	ENST00000570156.2	+	77	19711	c.19637C>T	c.(19636-19638)tCc>tTc	p.S6546F	OBSCN_ENST00000366707.4_Missense_Mutation_p.S3223F|OBSCN_ENST00000422127.1_Missense_Mutation_p.S5589F|OBSCN_ENST00000284548.11_Missense_Mutation_p.S5589F|OBSCN_ENST00000366709.4_Missense_Mutation_p.S2708F	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5589	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGGAGTCTTCCTCAGAGTCA	0.647000													4	15					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087253	92087253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92087253G>A	ENST00000298047.6	+	1	1992	c.1975G>A	c.(1975-1977)Gag>Aag	p.E659K	FAT3_ENST00000525166.1_Missense_Mutation_p.E509K|FAT3_ENST00000409404.2_Missense_Mutation_p.E659K|FAT3_ENST00000541502.1_Missense_Mutation_p.E659K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	659	Cadherin 6.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AACTGATGGAGAGAATCTTGC	0.393000										TCGA Ovarian(4;0.039)			7	39					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140532181	140532181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140532181G>A	ENST00000231136.1	+	1	2343	c.2343G>A	c.(2341-2343)atG>atA	p.M781I	PCDHB6_ENST00000543635.1_Missense_Mutation_p.M645I	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		781					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGAGAAATGGAAGAAACCC	0.433000													9	85					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49585792	49585792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49585792C>T	ENST00000371175.4	-	3	507	c.481G>A	c.(481-483)Gaa>Aaa	p.E161K	RHAG_ENST00000229810.7_Missense_Mutation_p.E161K	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	161					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					TTAAATATTTCACTAACCAGG	0.383000													5	40					0	0	1	0	0
CD48	962	broad.mit.edu	37	1	160654665	160654665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160654665C>T	ENST00000368045.3	-	2	436	c.397G>A	c.(397-399)Gag>Aag	p.E133K	CD48_ENST00000368046.3_Intron			P09326	CD48_HUMAN	CD48 molecule	133	Ig-like C2-type 2.				blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CTCTTTGGCTCCCCTGACTCA	0.542000													64	172					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165383628	165383628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165383628G>A	ENST00000263915.3	-	4	1037	c.499C>T	c.(499-501)Cac>Tac	p.H167Y	GRB14_ENST00000543549.1_Missense_Mutation_p.H80Y	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	167	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						ACCAGTTCGTGGTCTTCTATT	0.264000													24	79					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076249	9076249	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9076249G>A	ENST00000397910.4	-	3	11400	c.11197C>T	c.(11197-11199)Ctg>Ttg	p.L3733L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3734	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGAGTGGACAGAGAATCAAAC	0.498000													17	84					0	0	1	0	0
WNT2B	7482	broad.mit.edu	37	1	113059742	113059742	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113059742G>C	ENST00000369684.4	+	4	1166		c.e4-1		WNT2B_ENST00000369686.4_Splice_Site|WNT2B_ENST00000256640.5_Splice_Site	NM_024494.2	NP_078613.1	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B						chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCTCCCCCAGGCTGTGCGGC	0.567000													20	70					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628477	173628477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173628477G>A	ENST00000333279.2	-	2	141	c.81C>T	c.(79-81)gcC>gcT	p.A27A		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	43										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						ctggttcttgggcttcttctt	0.443000													9	22					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238303556	238303556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238303556C>T	ENST00000295550.4	-	3	835	c.383G>A	c.(382-384)aGc>aAc	p.S128N	COL6A3_ENST00000353578.4_Intron|COL6A3_ENST00000392004.3_Intron|COL6A3_ENST00000392003.2_Intron|COL6A3_ENST00000409809.1_Intron|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000346358.4_Missense_Mutation_p.S128N|COL6A3_ENST00000347401.3_Missense_Mutation_p.S128N	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	128	Nonhelical region.|VWFA 1.			QS -> AK (in Ref. 4; AAB24261).	axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGTGAGGTGGCTTTGCATTAT	0.478000													43	81					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51795149	51795149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51795149G>A	ENST00000251076.5	-	17	3133	c.2846C>T	c.(2845-2847)tCt>tTt	p.S949F	DMXL2_ENST00000543779.2_Missense_Mutation_p.S949F|DMXL2_ENST00000449909.3_Intron	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	949						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		CACACTAGGAGAGGTTTCTGG	0.418000													23	125					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99446978	99446978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:99446978G>A	ENST00000547776.2	-	17	2734	c.2735C>T	c.(2734-2736)tCg>tTg	p.S912L	ANKS1B_ENST00000549493.2_Missense_Mutation_p.S138L|ANKS1B_ENST00000329257.7_Missense_Mutation_p.S912L|ANKS1B_ENST00000546960.1_Missense_Mutation_p.S138L|ANKS1B_ENST00000547010.1_Missense_Mutation_p.S488L|ANKS1B_ENST00000550693.2_Missense_Mutation_p.S138L|ANKS1B_ENST00000547446.1_Missense_Mutation_p.S107L|ANKS1B_ENST00000549558.2_Missense_Mutation_p.S138L|ANKS1B_ENST00000332712.7_Missense_Mutation_p.S138L|ANKS1B_ENST00000546568.1_Missense_Mutation_p.S138L|ANKS1B_ENST00000549025.2_Missense_Mutation_p.S81L	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	912	SAM 2.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane		p.S912L(1)		NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CAGGTCCATCGAAGTGTAGCC	0.408000													3	10					0	0	1	0	0
SLC18A2	6571	broad.mit.edu	37	10	119029946	119029946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:119029946G>A	ENST00000298472.5	+	15	1555	c.1412G>A	c.(1411-1413)cGa>cAa	p.R471Q	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	471					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TTTTTTCTTCGAAGTCCACCT	0.393000													18	109					0	0	1	0	0
LAT2	7462	broad.mit.edu	37	7	73631186	73631186	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73631186G>A	ENST00000460943.1	+	4	1015	c.126G>A	c.(124-126)caG>caA	p.Q42Q	LAT2_ENST00000275635.7_Silent_p.Q42Q|LAT2_ENST00000398475.1_Silent_p.Q42Q|LAT2_ENST00000344995.5_Silent_p.Q42Q	NM_032464.2	NP_115853.2	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family, member 2	42					B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6						TCTACCAGCAGAGAAGTCTGT	0.562000													13	70					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33696190	33696190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33696190C>T	ENST00000253193.7	+	5	716	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C	LRP3_ENST00000592484.1_3'UTR	NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	172	LDL-receptor class A 1.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					AGATGAGTTCCGCTGTGACAA	0.662000													3	11					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096187	167096187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167096187G>A	ENST00000361200.2	+	6	1985	c.1819G>A	c.(1819-1821)Gag>Aag	p.E607K	DUSP27_ENST00000443333.1_Missense_Mutation_p.E607K|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.E607K			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	607					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GAACAAGGAGGAGGTGGTGGA	0.612000													5	30					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745185	140745185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140745185C>T	ENST00000518069.1	+	1	1288	c.1288C>T	c.(1288-1290)Ccg>Tcg	p.P430S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGGAACCCCGCCCCTCTC	0.458000													45	115					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057754	9057754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9057754G>A	ENST00000397910.4	-	3	29895	c.29692C>T	c.(29692-29694)Ctt>Ttt	p.L9898F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9900	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTCCATAAAGGACTGCACTT	0.468000													28	89					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73964162	73964162	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73964162G>A	ENST00000373468.1	-	3	881	c.230C>T	c.(229-231)cCg>cTg	p.P77L	KIAA2022_ENST00000055682.5_Missense_Mutation_p.P77L			Q5QGS0	K2022_HUMAN	KIAA2022	77					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity	p.P77L(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						AGGAGAGGGCGGGCTCTGCAT	0.542000													31	21					0	0	1	0	0
MARC1	64757	broad.mit.edu	37	1	220970064	220970064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:220970064C>T	ENST00000366910.5	+	3	715	c.529C>T	c.(529-531)Ccc>Tcc	p.P177S	MARC1_ENST00000496110.1_3'UTR	NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	177							molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										GAAGTCACAGCCCTACCGCCT	0.602000													12	35					0	0	1	0	0
OR5P2	120065	broad.mit.edu	37	11	7817892	7817892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7817892C>T	ENST00000329434.2	-	1	628	c.598G>A	c.(598-600)Gga>Aga	p.G200R	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ATGATGGATCCAGAAGAAAAT	0.453000													8	83					0	0	1	0	0
LY6D	8581	broad.mit.edu	37	8	143867029	143867029	+	Missense_Mutation	SNP	G	G	A	rs144613234		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143867029G>A	ENST00000301263.4	-	2	202	c.127C>T	c.(127-129)Cgc>Tgc	p.R43C	RP11-706C16.8_ENST00000510610.2_RNA|LY6D_ENST00000518434.1_5'UTR	NM_003695.2	NP_003686.1	Q14210	LY6D_HUMAN	lymphocyte antigen 6 complex, locus D	43	UPAR/Ly6.				cell adhesion	anchored to membrane|membrane fraction|plasma membrane	protein binding			large_intestine(1)|lung(3)|prostate(1)	5	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TTGCAGAAGCGAGAGCTGGCC	0.637000													33	51					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214865	161214865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161214865C>T	ENST00000327928.4	+	1	270	c.270C>T	c.(268-270)ttC>ttT	p.F90F		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	90						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						TTGAAAACTTCACTCTTGACC	0.473000													34	155					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73636582	73636582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:73636582C>T	ENST00000377687.4	+	2	1381	c.845C>T	c.(844-846)cCc>cTc	p.P282L	KLF5_ENST00000539231.1_Missense_Mutation_p.P191L|KLF5_ENST00000477333.1_3'UTR	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	282					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CAGGGCATGCCCCCTTGCACA	0.507000													45	74					0	0	1	0	0
WBSCR27	155368	broad.mit.edu	37	7	73254755	73254755	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73254755G>A	ENST00000297873.4	-	4	426	c.377C>T	c.(376-378)cCc>cTc	p.P126L		NM_152559.2	NP_689772.2	Q8N6F8	WBS27_HUMAN	Williams Beuren syndrome chromosome region 27	126										NS(1)|central_nervous_system(1)|lung(2)|prostate(1)	5		Lung NSC(55;0.159)				TTCCGGGCTGGGCAGAGGCTC	0.652000													8	10					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8471043	8471043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8471043C>T	ENST00000381196.4	-	28	3999	c.3456G>A	c.(3454-3456)ggG>ggA	p.G1152G	PTPRD_ENST00000397611.3_Silent_p.G738G|PTPRD_ENST00000397617.3_Silent_p.G731G|PTPRD_ENST00000540109.1_Silent_p.G1152G|PTPRD_ENST00000360074.4_Silent_p.G1139G|PTPRD_ENST00000537002.1_Silent_p.G738G|PTPRD_ENST00000358503.5_Silent_p.G1130G|PTPRD_ENST00000486161.1_Silent_p.G741G|PTPRD_ENST00000356435.5_Silent_p.G1152G|PTPRD_ENST00000355233.5_Silent_p.G741G|PTPRD_ENST00000397606.3_Silent_p.G731G	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1152					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGATAAATTTCCCGCGAGATT	0.368000										TSP Lung(15;0.13)			13	121					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8449744	8449744	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8449744G>A	ENST00000381196.4	-	31	4512	c.3969C>T	c.(3967-3969)cgC>cgT	p.R1323R	PTPRD_ENST00000397611.3_Silent_p.R913R|PTPRD_ENST00000397617.3_Silent_p.R902R|PTPRD_ENST00000540109.1_Silent_p.R1323R|PTPRD_ENST00000360074.4_Silent_p.R1310R|PTPRD_ENST00000537002.1_Silent_p.R913R|PTPRD_ENST00000358503.5_Silent_p.R1301R|PTPRD_ENST00000486161.1_Silent_p.R916R|PTPRD_ENST00000356435.5_Silent_p.R1323R|PTPRD_ENST00000355233.5_Silent_p.R917R|PTPRD_ENST00000397606.3_Silent_p.R902R	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1323					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAAAGTTAAGGCGCCTCAGTT	0.453000										TSP Lung(15;0.13)			16	126					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064119	6064119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6064119C>T	ENST00000409021.3	-	10	1929	c.1480G>A	c.(1480-1482)Gag>Aag	p.E494K	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.E329K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.E494K|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.E309K|JAKMIP1_ENST00000457227.2_Intron|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.E494K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	494	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCCTGGTACTCCCGGGTCAGC	0.587000													26	74					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52240817	52240817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52240817G>A	ENST00000282588.6	+	27	3788	c.3330G>A	c.(3328-3330)cgG>cgA	p.R1110R	CTD-2175A23.1_ENST00000505701.1_RNA|CTD-2175A23.1_ENST00000503559.1_RNA	NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	1110					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GAGAACTTCGGAGTGAAAATG	0.323000													20	175					0	0	1	0	0
HOXB13	10481	broad.mit.edu	37	17	46805893	46805893	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46805893C>T	ENST00000290295.7	-	1	647	c.63G>A	c.(61-63)gcG>gcA	p.A21A		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	21					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GCCCCCCTCCCGCTCCCAGCA	0.657000													17	16					0	0	1	0	0
CD3E	916	broad.mit.edu	37	11	118183390	118183390	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118183390G>A	ENST00000361763.4	+	6	452	c.161G>A	c.(160-162)gGa>gAa	p.G54E	CD3E_ENST00000528600.1_Missense_Mutation_p.G48E	NM_000733.3	NP_000724.1	P07766	CD3E_HUMAN	CD3e molecule, epsilon (CD3-TCR complex)	54	Ig-like.				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|ovary(2)|stomach(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	CAGTATCCTGGATCTGAAATA	0.413000													90	176					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103299894	103299894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103299894C>T	ENST00000233969.2	+	4	1321	c.1179C>T	c.(1177-1179)ttC>ttT	p.F393F		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	393						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						ACTGGGCCTTCGTCTGCTTCA	0.507000													8	75					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32466746	32466746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:32466746C>T	ENST00000357033.4	-	27	3819	c.3613G>A	c.(3613-3615)Gaa>Aaa	p.E1205K	DMD_ENST00000378677.2_Missense_Mutation_p.E1201K	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1205					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGGGCCTCTTCTTTAGCTCTC	0.348000													25	26					0	0	1	0	0
SLC35E4	339665	broad.mit.edu	37	22	31032727	31032727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31032727G>A	ENST00000343605.4	+	1	1089	c.290G>A	c.(289-291)gGg>gAg	p.G97E	SLC35E4_ENST00000406566.1_Missense_Mutation_p.G97E|SLC35E4_ENST00000300385.8_Missense_Mutation_p.G97E	NM_001001479.2	NP_001001479.1	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	97						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						TGCCACCGGGGGGCACGGCGC	0.667000													8	20					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187627274	187627274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:187627274C>T	ENST00000304698.5	+	8	2408	c.2205C>T	c.(2203-2205)atC>atT	p.I735I		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	735						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						AGCCCAAGATCCTTTACTTAG	0.488000													33	97					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90281242	90281242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90281242G>A	ENST00000405460.2	+	85	18151	c.18055G>A	c.(18055-18057)Gga>Aga	p.G6019R	GPR98_ENST00000425867.2_Missense_Mutation_p.G1680R	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6019					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTGAGTTGGGGACTACCAGC	0.418000													12	40					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142650990	142650990	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142650990C>T	ENST00000355265.2	-	9	1452	c.978G>A	c.(976-978)ccG>ccA	p.P326P	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	326					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCAGGGACATCGGTGTGAATG	0.522000													40	166					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39959963	39959963	+	Silent	SNP	C	C	T	rs147765614		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39959963C>T	ENST00000599117.1	+	17	1666	c.1299C>T	c.(1297-1299)ctC>ctT	p.L433L	SUPT5H_ENST00000598725.1_Silent_p.L433L|SUPT5H_ENST00000402194.2_Silent_p.L429L|SUPT5H_ENST00000359191.6_Silent_p.L429L|SUPT5H_ENST00000432763.2_Silent_p.L433L			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	433	KOW 2.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGGGTGAGCTCATCAACCTGC	0.612000													9	23					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159028717	159028717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:159028717G>A	ENST00000283233.5	-	14	1997	c.1684C>T	c.(1684-1686)Cat>Tat	p.H562Y	CCDC148-AS1_ENST00000412781.2_RNA|CCDC148_ENST00000409187.1_Missense_Mutation_p.H571Y	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	562										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						AGTGTTCTATGAAGTCCAGCT	0.323000													8	88					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10515185	10515185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:10515185C>T	ENST00000226951.6	-	16	1048	c.809G>A	c.(808-810)aGa>aAa	p.R270K	CLNK_ENST00000515667.1_Missense_Mutation_p.R8K	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	270					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						AGGCTGGCATCTCTGAGGAGA	0.493000													6	16					0	0	1	0	0
TAC3	6866	broad.mit.edu	37	12	57409509	57409509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57409509C>T	ENST00000458521.2	-	2	232	c.73G>A	c.(73-75)Gag>Aag	p.E25K	TAC3_ENST00000415231.1_Missense_Mutation_p.E25K|TAC3_ENST00000441881.1_Missense_Mutation_p.E25K	NM_013251.3	NP_037383.1	Q9UHF0	TKNK_HUMAN	tachykinin 3	25					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						TCCTGTGGCTCCTTACAGACA	0.597000													15	60					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541971	133541971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133541971G>A	ENST00000409261.1	-	14	2786	c.2413C>T	c.(2413-2415)Ccc>Tcc	p.P805S	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.P805S	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	805							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTGCCCCTGGGAGGTATTTTT	0.463000													21	282					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18333104	18333104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18333104C>T	ENST00000355502.3	-	6	1143	c.272G>A	c.(271-273)gGg>gAg	p.G91E	PDE4C_ENST00000594465.2_Missense_Mutation_p.G91E|PDE4C_ENST00000262805.11_Missense_Mutation_p.G59E|PDE4C_ENST00000447275.2_5'UTR|PDE4C_ENST00000594617.2_Missense_Mutation_p.G91E			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	91					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GGCCCTCCTCCCACACGAGAG	0.637000													6	65					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88173915	88173915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88173915G>A	ENST00000507897.1	+	13	1899	c.1816G>A	c.(1816-1818)Gaa>Aaa	p.E606K	C6ORF165_ENST00000369562.4_Missense_Mutation_p.E606K|C6orf165_ENST00000506888.1_3'UTR			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	606										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGGAAAGAGCGAAATCACCGA	0.458000													17	31					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182755102	182755102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:182755102G>A	ENST00000492597.1	-	12	1873	c.1171C>T	c.(1171-1173)Cgg>Tgg	p.R391W	MCCC1_ENST00000265594.4_Missense_Mutation_p.R500W|MCCC1_ENST00000539926.1_Missense_Mutation_p.R365W|MCCC1_ENST00000489909.1_5'UTR			Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	500	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	GCAGCCTTCCGACTGAGCAAC	0.507000													6	80					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35793034	35793034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35793034C>T	ENST00000342694.2	+	1	884	c.629C>T	c.(628-630)cCc>cTc	p.P210L		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	210					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CCAGGGGGCCCCGAGCAGGCC	0.637000													6	35					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36036043	36036043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36036043G>A	ENST00000282507.3	-	7	1430	c.1329C>T	c.(1327-1329)atC>atT	p.I443I	UGT3A2_ENST00000513300.1_Silent_p.I409I|UGT3A2_ENST00000545528.1_Silent_p.I141I	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	443						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGGAGCGCAGGATGACACTGG	0.577000													11	38					0	0	1	0	0
DNAJC11	55735	broad.mit.edu	37	1	6741093	6741093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6741093G>A	ENST00000377577.5	-	2	200	c.77C>T	c.(76-78)tCt>tTt	p.S26F	DNAJC11_ENST00000294401.7_Missense_Mutation_p.S26F|DNAJC11_ENST00000542246.1_5'UTR|DNAJC11_ENST00000377573.5_5'UTR|DNAJC11_ENST00000349363.6_5'UTR	NM_018198.3	NP_060668.2	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	26	J.				protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTTCAGAAGAGGCCTAAAG	0.453000													10	90					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56057736	56057736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56057736C>T	ENST00000313022.2	-	1	830	c.803G>A	c.(802-804)gGa>gAa	p.G268E		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					TTGATCCCTTCCCAAAGAATA	0.338000													36	95					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111030	7111030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7111030G>A	ENST00000306904.5	+	1	866	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	227	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGACTACCGCGAACCCCGGGG	0.706000													8	24					0	0	1	0	0
NAALADL2	254827	broad.mit.edu	37	3	175184890	175184890	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:175184890G>A	ENST00000454872.1	+	8	1579	c.1451G>A	c.(1450-1452)gGg>gAg	p.G484E	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	484					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GTTAAGAGAGGGTGGAGACCA	0.423000													39	102					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101351026	101351026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101351026C>T	ENST00000534062.1	-	1	158	c.100G>A	c.(100-102)Gag>Aag	p.E34K		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	34										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						GACGTCGCCTCGGTGGTGTTG	0.572000													13	24					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10436605	10436605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10436605C>T	ENST00000245503.5	-	21	2822	c.2438G>A	c.(2437-2439)aGa>aAa	p.R813K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.R813K|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	813	IQ.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTTATACCTTCTCTCCACCAT	0.433000													51	61					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151164261	151164261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151164261C>T	ENST00000282466.3	-	4	3507	c.3508G>A	c.(3508-3510)Gaa>Aaa	p.E1170K		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1170					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTTTTAGCTTCATTGGTGCTA	0.418000													106	273					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159571	18159571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18159571C>T	ENST00000396275.2	+	3	1183	c.822C>T	c.(820-822)ttC>ttT	p.F274F		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	274						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TTTACTTCTTCGTGGGCTCCT	0.512000													48	105					0	0	1	0	0
C19orf52	90580	broad.mit.edu	37	19	11040106	11040106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11040106C>T	ENST00000270502.6	+	2	601	c.511C>T	c.(511-513)Cgc>Tgc	p.R171C		NM_138358.2	NP_612367.1	Q9BSF4	CS052_HUMAN	chromosome 19 open reading frame 52	171										prostate(1)	1						CTTCGTGGGTCGCTGGTGGGT	0.701000													16	21					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210414947	210414947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210414947C>T	ENST00000367012.3	+	4	566	c.336C>T	c.(334-336)tcC>tcT	p.S112S	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	112	SERTA.						protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TTTATATGTCCTTAGAAAAGC	0.338000													23	113					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30803094	30803094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30803094G>A	ENST00000383096.3	-	18	2090	c.1908C>T	c.(1906-1908)acC>acT	p.T636T	CCDC178_ENST00000406524.2_Silent_p.T636T|CCDC178_ENST00000300227.8_Intron|CCDC178_ENST00000579947.1_Silent_p.T636T|CCDC178_ENST00000402325.1_Silent_p.T636T|CCDC178_ENST00000583930.1_Silent_p.T636T|CCDC178_ENST00000403303.1_Silent_p.T636T|CCDC178_ENST00000579916.1_Intron					coiled-coil domain containing 178																		ATGCATCAAGGGTTTTCTTCC	0.279000													8	43					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170044495	170044495	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170044495C>T	ENST00000263816.3	-	49	9598	c.9313G>A	c.(9313-9315)Gat>Aat	p.D3105N		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3105	LDL-receptor class A 25.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCTTTCTCATCGCTGTTGTCC	0.483000													23	95					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179588821	179588821	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179588821C>T	ENST00000589042.1	-	73	21389	c.21165G>A	c.(21163-21165)ggG>ggA	p.G7055G	TTN_ENST00000342992.6_Silent_p.G5811G|TTN_ENST00000591111.1_Silent_p.G6738G|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|RP11-171I2.1_ENST00000590024.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6738	Ig-like 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACCTAACACCCCACCAGTAT	0.433000													7	30					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20045034	20045034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20045034C>T	ENST00000343769.5	+	4	1298	c.1270C>T	c.(1270-1272)Ccc>Tcc	p.P424S	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	424						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						TGGAGAGAAACCCTACAAATG	0.408000													21	88					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57945727	57945727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57945727G>A	ENST00000564448.1	-	25	2464	c.2404C>T	c.(2404-2406)Ctt>Ttt	p.L802F	CNGB1_ENST00000251102.8_Missense_Mutation_p.L808F			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	808					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						CAGTAATAAAGACAGGAATTC	0.582000													15	43					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178555117	178555117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178555117G>A	ENST00000251582.7	-	17	2561	c.2460C>T	c.(2458-2460)gtC>gtT	p.V820V		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	820	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCACCGGGATGACCTGTGCCA	0.582000													16	46					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64608117	64608117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:64608117G>A	ENST00000357395.3	+	82	15334	c.4190G>A	c.(4189-4191)gGg>gAg	p.G1397E	ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000344113.4_Missense_Mutation_p.G5012E|SYNE2_ENST00000554584.1_Missense_Mutation_p.G4929E|SYNE2_ENST00000555002.1_Missense_Mutation_p.G1646E|SYNE2_ENST00000358025.3_Missense_Mutation_p.G5012E|SYNE2_ENST00000394768.2_Missense_Mutation_p.G1397E			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5012					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATCAGTATCGGGAACCAGCTT	0.348000													25	80					0	0	1	0	0
MRPL4	51073	broad.mit.edu	37	19	10368916	10368916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10368916C>T	ENST00000393733.2	+	6	491	c.464C>T	c.(463-465)cCc>cTc	p.P155L	MRPL4_ENST00000588502.1_Missense_Mutation_p.P154L|CTD-2369P2.5_ENST00000592893.1_RNA|MRPL4_ENST00000590669.1_Missense_Mutation_p.P155L|MRPL4_ENST00000307422.5_Missense_Mutation_p.P155L|MRPL4_ENST00000253099.6_Missense_Mutation_p.P155L			Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4	155					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		GCCCATGGCCCCCGGGGCCCC	0.637000													5	39					0	0	1	0	0
MBLAC2	153364	broad.mit.edu	37	5	89757138	89757138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89757138G>A	ENST00000316610.6	-	2	1161	c.686C>T	c.(685-687)cCt>cTt	p.P229L		NM_203406.1	NP_981951.1	Q68D91	MBLC2_HUMAN	metallo-beta-lactamase domain containing 2	229							hydrolase activity|metal ion binding			kidney(1)|liver(1)|lung(3)	5						GAAGTGCCCAGGAAGCACCTT	0.423000													15	114					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819642	159819642	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159819642G>A	ENST00000497452.1	-	0	517																											GTGCGAATTTGAAAGAAGAAA	0.488000													68	171					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657088	143657088	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143657088G>A	ENST00000392899.1	+	1	62	c.25G>A	c.(25-27)Gtg>Atg	p.V9M		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					CCAGACTTGGGTGAGTGAATT	0.428000													15	159					0	0	1	0	0
NCEH1	57552	broad.mit.edu	37	3	172428810	172428810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172428810G>A	ENST00000538775.1	-	1	198	c.61C>T	c.(61-63)Ctt>Ttt	p.L21F	NCEH1_ENST00000543711.1_5'UTR|NCEH1_ENST00000475381.1_5'UTR|NCEH1_ENST00000273512.3_Missense_Mutation_p.L21F	NM_001146276.1	NP_001139748.1	Q6PIU2	NCEH1_HUMAN	neutral cholesterol ester hydrolase 1	0					lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)	15						GGCTGGCAAAGAGGAAAGGGC	0.627000											OREG0015927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	64					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175304863	175304863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175304863C>T	ENST00000367674.1	-	20	4323	c.3615G>A	c.(3613-3615)gaG>gaA	p.E1205E	TNR_ENST00000263525.2_Silent_p.E1205E	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1205	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					AGAACTCATCCTCCACGTTCC	0.443000													10	121					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839224	62839224	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62839224C>T	ENST00000536311.1	+	7	1039	c.675C>T	c.(673-675)gtC>gtT	p.V225V	MYT1_ENST00000328439.1_Silent_p.V225V|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	225	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGGAGGTCGTCGAAGTCACCA	0.617000													13	31					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30890998	30890998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30890998C>T	ENST00000321897.5	+	23	2935	c.2303C>T	c.(2302-2304)cCt>cTt	p.P768L	VARS2_ENST00000542001.1_Missense_Mutation_p.P628L|VARS2_ENST00000541562.1_Missense_Mutation_p.P798L|VARS2_ENST00000416670.2_Missense_Mutation_p.P768L|VARS2_ENST00000476162.1_3'UTR			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	768					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						GTGCCACAGCCTGCTGAGGAG	0.532000													30	130					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23758277	23758277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23758277C>T	ENST00000336689.3	-	23	2502	c.2458G>A	c.(2458-2460)Gag>Aag	p.E820K	ASAP3_ENST00000437606.2_Missense_Mutation_p.E811K|ASAP3_ENST00000484906.1_Intron|ASAP3_ENST00000495646.1_Missense_Mutation_p.E324K	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	820					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						CGGAGGCCCTCTTCAGAGTTG	0.652000													46	107					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75977862	75977862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75977862G>A	ENST00000308508.5	-	4	4062	c.3970C>T	c.(3970-3972)Cgc>Tgc	p.R1324C		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1324	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GCCTCAGGGCGGGAGTGCAGG	0.682000													5	17					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62330131	62330131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62330131G>A	ENST00000371158.2	+	20	2775	c.2661G>A	c.(2659-2661)gaG>gaA	p.E887E	INADL_ENST00000316485.6_Silent_p.E887E	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	887					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CATCCATGGAGTTGTATCCCT	0.418000													29	89					0	0	1	0	0
FAM114A1	92689	broad.mit.edu	37	4	38937369	38937369	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:38937369C>T	ENST00000358869.2	+	13	1670	c.1494C>T	c.(1492-1494)gcC>gcT	p.A498A	FAM114A1_ENST00000513966.1_3'UTR|FAM114A1_ENST00000515037.1_Silent_p.A291A	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1	498						cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						ATGAAGTGGCCTCTTTATCAA	0.323000													13	73					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638545	234638545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234638545G>A	ENST00000482026.1	+	1	792	c.773G>A	c.(772-774)cGa>cAa	p.R258Q	UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000373445.1_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TGGCTGTTCCGAGGGGACTTT	0.507000													99	231					0	0	1	0	0
NUP107	57122	broad.mit.edu	37	12	69109411	69109411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:69109411C>T	ENST00000229179.4	+	12	1306	c.974C>T	c.(973-975)cCt>cTt	p.P325L	NUP107_ENST00000539906.1_Missense_Mutation_p.P296L|NUP107_ENST00000378905.2_Missense_Mutation_p.P174L	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	325					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TTACAGGACCCTGATGCTCCC	0.358000													43	95					0	0	1	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077169	19077169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:19077169G>A	ENST00000329773.2	-	2	868	c.781C>T	c.(781-783)Cat>Tat	p.H261Y		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	261					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						GAAACTGGATGAATATGACAA	0.483000													34	87					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61687892	61687892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:61687892C>T	ENST00000577390.1	-	12	2974	c.2020G>A	c.(2020-2022)Gag>Aag	p.E674K	CDH8_ENST00000577730.1_Missense_Mutation_p.E674K|CDH8_ENST00000299345.6_Missense_Mutation_p.E674K	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	674					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GTGTCCTCCTCCCCTCCTCCT	0.383000													61	134					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87026001	87026001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87026001C>T	ENST00000370563.3	+	3	450	c.408C>T	c.(406-408)gaC>gaT	p.D136D	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	136						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TCACCCCTGACCTTCTACTTG	0.388000													35	69					0	0	1	0	0
SF3B2	10992	broad.mit.edu	37	11	65829159	65829159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65829159G>A	ENST00000528302.1	+	14	1785	c.1731G>A	c.(1729-1731)ggG>ggA	p.G577G	SF3B2_ENST00000322535.6_Silent_p.G594G			Q13435	SF3B2_HUMAN	splicing factor 3b, subunit 2, 145kDa	594					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	41						TCCCTCAGGGGAAGGAGTTCG	0.502000													17	48					0	0	1	0	0
MNX1	3110	broad.mit.edu	37	7	156798568	156798568	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:156798568C>T	ENST00000252971.6	-	3	1153		c.e3-1		MNX1_ENST00000469500.1_Intron|MNX1_ENST00000543409.1_Splice_Site	NM_005515.3	NP_005506.3	P50219	MNX1_HUMAN	motor neuron and pancreas homeobox 1						humoral immune response|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(4)|skin(1)	7	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAATCTTCACCTGCGGGCACA	0.672000													14	55					0	0	1	0	0
IGHV3-35	28432	broad.mit.edu	37	14	106845368	106845368	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106845368C>T	ENST00000390617.2	-	0	320																											TCAGGCTATTCGTTTGCAGAT	0.517000													54	224					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476410	57476410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57476410C>T	ENST00000371236.2	-	14	1889	c.1626G>A	c.(1624-1626)ggG>ggA	p.G542G	DAB1_ENST00000420954.2_Silent_p.G540G|DAB1_ENST00000439789.2_Silent_p.G456G|DAB1_ENST00000371234.4_Silent_p.G542G|DAB1_ENST00000371231.1_Silent_p.G575G|DAB1_ENST00000414851.2_Silent_p.G524G|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	575					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CACTGGGCTCCCCACTGGGCT	0.448000													12	129					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54617553	54617553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:54617553C>T	ENST00000302287.3	+	4	730	c.324C>T	c.(322-324)atC>atT	p.I108I	VSTM2A_ENST00000407838.3_Silent_p.I108I|VSTM2A_ENST00000402026.2_Silent_p.I107I|VSTM2A_ENST00000498834.1_3'UTR|VSTM2A_ENST00000402613.3_Silent_p.I108I|VSTM2A_ENST00000404951.1_Silent_p.I108I			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	108	Ig-like V-type.					extracellular region		p.I107I(2)|p.I108I(1)		endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			GCAATGACATCTCCCACAAGC	0.408000													10	24					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5567942	5567942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5567942G>A	ENST00000331789.5	-	4	963	c.772C>T	c.(772-774)Cct>Tct	p.P258S		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	258					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		AGTGCCTCAGGGCAGCGGAAC	0.617000													36	94					0	0	1	0	0
EDDM3A	10876	broad.mit.edu	37	14	21216087	21216087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21216087G>A	ENST00000326842.2	+	2	475	c.348G>A	c.(346-348)gaG>gaA	p.E116E		NM_006683.4	NP_006674.2	Q14507	EP3A_HUMAN	epididymal protein 3A	116					sperm displacement	extracellular space				breast(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	6						GGTACACAGAGAGCAGAAGCT	0.443000													20	63					0	0	1	0	0
FNDC4	64838	broad.mit.edu	37	2	27715556	27715556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27715556C>T	ENST00000264703.3	-	6	1037	c.646G>A	c.(646-648)Gga>Aga	p.G216R		NM_022823.2	NP_073734.1	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	216						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|prostate(1)|skin(1)	9	Acute lymphoblastic leukemia(172;0.155)					ACTGGCCTTCCCTGAGGACTC	0.557000													35	144					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130060507	130060507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130060507C>T	ENST00000278742.5	+	7	1211	c.793C>T	c.(793-795)Ctt>Ttt	p.L265F		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	265	CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	CAGCTTTGACCTTGCGTCCTG	0.701000													7	22					0	0	1	0	0
DIABLO	56616	broad.mit.edu	37	12	122702927	122702927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122702927G>A	ENST00000535844.1	-	13	1626	c.1612C>T	c.(1612-1614)Cct>Tct	p.P538S	DIABLO_ENST00000413918.1_Intron|DIABLO_ENST00000464942.2_Silent_p.S14S|DIABLO_ENST00000443649.3_Silent_p.S67S|DIABLO_ENST00000353548.6_Intron|DIABLO_ENST00000267169.6_Silent_p.S14S																							CACTACTAAGGGAATGAGGCT	0.398000													13	82					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54958874	54958874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54958874C>T	ENST00000273286.5	-	2	538	c.376G>A	c.(376-378)Gag>Aag	p.E126K	CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.E50K|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	126						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		AAATCAAGCTCCCTCAGCTGA	0.463000													20	57					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94487106	94487106	+	Missense_Mutation	SNP	G	G	A	rs56099091	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:94487106G>A	ENST00000375708.3	-	9	1868	c.1670C>T	c.(1669-1671)tCg>tTg	p.S557L	ROR2_ENST00000375715.1_Missense_Mutation_p.S417L|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	557	Protein kinase.		S -> L (in dbSNP:rs56099091).		negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.S557L(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GTCGCCGTGCGAACAGTAGCT	0.652000													9	47					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71839936	71839936	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71839936G>A	ENST00000258104.3	+	39	4610	c.4333_splice	c.e39+1	p.D1445_splice	DYSF_ENST00000410041.1_Splice_Site_p.D1463_splice|DYSF_ENST00000429174.2_Splice_Site_p.D1445_splice|DYSF_ENST00000409744.1_Splice_Site_p.D1432_splice|DYSF_ENST00000410020.3_Splice_Site_p.D1463_splice|DYSF_ENST00000394120.2_Splice_Site_p.D1446_splice|DYSF_ENST00000409366.1_Splice_Site_p.D1446_splice|DYSF_ENST00000409582.3_Splice_Site_p.D1462_splice|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Splice_Site_p.D1476_splice|DYSF_ENST00000409651.1_Splice_Site_p.D1477_splice|DYSF_ENST00000409762.1_Splice_Site_p.D1462_splice	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1445						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GGGTGGCCCAGGTAGGGGAAG	0.632000													7	28					0	0	1	0	0
TEX37	200523	broad.mit.edu	37	2	88828854	88828854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:88828854C>T	ENST00000303254.3	+	4	547	c.405C>T	c.(403-405)ctC>ctT	p.L135L		NM_152670.2	NP_689883.1			testis expressed 37																		TTCCGTGCCTCGTGGATCCCA	0.572000													29	62					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35829247	35829247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35829247C>T	ENST00000085219.5	+	6	1228	c.1162C>T	c.(1162-1164)Ccc>Tcc	p.P388S	CD22_ENST00000536635.2_Intron|CD22_ENST00000270311.6_Missense_Mutation_p.P268S|CD22_ENST00000544992.2_Missense_Mutation_p.P388S|CD22_ENST00000594250.1_Intron|CD22_ENST00000419549.2_Missense_Mutation_p.P216S|CD22_ENST00000341773.6_Intron	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	388	Ig-like C2-type 3.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AAAGATCCTCCCCTGGCACGC	0.532000													31	80					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897943	175897943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175897943C>T	ENST00000359240.3	+	5	1937	c.1267C>T	c.(1267-1269)Ccc>Tcc	p.P423S	ADAM29_ENST00000445694.1_Missense_Mutation_p.P423S|ADAM29_ENST00000404450.4_Missense_Mutation_p.P423S|ADAM29_ENST00000514159.1_Missense_Mutation_p.P423S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	423	Disintegrin.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGCAAAAGATCCCTGCTGTCT	0.443000													33	91					0	0	1	0	0
ANKRD20A11P	391267	broad.mit.edu	37	21	15352085	15352085	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:15352085C>T	ENST00000344693.5	-	0	673					NR_027270.1																						GCTCCATCTCCGCGGCGTCGC	0.667000													5	29					0	0	1	0	0
CHIAP2	149620	broad.mit.edu	37	1	111827633	111827633	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111827633G>A	ENST00000369743.4	+	0	1732					NR_003928.1																						CAACTTTGGAGGTGCCATGGT	0.488000													3	6					0	0	1	0	0
HTRA1	5654	broad.mit.edu	37	10	124248484	124248484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124248484C>T	ENST00000368984.3	+	2	667	c.539C>T	c.(538-540)gCc>gTc	p.A180V		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	180					proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				GAGAAGATCGCCCCTGCCGTG	0.448000													37	108					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108872124	108872124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108872124G>A	ENST00000329106.2	+	4	496	c.496G>A	c.(496-498)Gaa>Aaa	p.E166K	SULT1C3_ENST00000376700.1_Missense_Mutation_p.E166K	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	166						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						GAACTTAGAGGAATTTTATGA	0.428000													7	94					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58620087	58620087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58620087C>T	ENST00000358781.2	-	10	904	c.594G>A	c.(592-594)aaG>aaA	p.K198K	RP11-475O23.3_ENST00000464125.1_RNA	NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	198					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CTGGGCTGTTCTTTAAGAACT	0.507000													34	79					0	0	1	0	0
NR3C1	2908	broad.mit.edu	37	5	142779665	142779665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:142779665G>A	ENST00000343796.2	-	2	1733	c.740C>T	c.(739-741)cCt>cTt	p.P247L	NR3C1_ENST00000394466.2_Missense_Mutation_p.P247L|NR3C1_ENST00000415690.2_Missense_Mutation_p.P247L|NR3C1_ENST00000504572.1_Missense_Mutation_p.P247L|NR3C1_ENST00000231509.3_Missense_Mutation_p.P247L|NR3C1_ENST00000394464.2_Missense_Mutation_p.P247L|NR3C1_ENST00000416954.2_Intron|NR3C1_ENST00000424646.2_Missense_Mutation_p.P247L|NR3C1_ENST00000503201.1_Missense_Mutation_p.P247L	NM_001018074.1|NM_001018075.1|NM_001018077.1	NP_001018084.1|NP_001018085.1|NP_001018087.1	P04150	GCR_HUMAN	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	247	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	35		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TAAAATGAGAGGCTTGCAGTC	0.423000													59	137					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62941524	62941524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62941524G>A	ENST00000251157.5	-	45	5815	c.5782C>T	c.(5782-5784)Cgt>Tgt	p.R1928C	DOCK7_ENST00000489185.1_5'UTR|DOCK7_ENST00000340370.5_Missense_Mutation_p.R1908C	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1939	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						ATGAATCGACGAAGATTGTAA	0.403000													48	121					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711093	58711093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58711093G>A	ENST00000300079.5	+	2	152	c.102G>A	c.(100-102)caG>caA	p.Q34Q	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_5'UTR	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	ggtacctgcaggatccaattg	0.473000													13	43					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471412	47471412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:47471412C>T	ENST00000266581.4	-	2	1840	c.1374G>A	c.(1372-1374)cgG>cgA	p.R458R	AMIGO2_ENST00000429635.1_Silent_p.R458R|AMIGO2_ENST00000550413.1_Silent_p.R458R|AMIGO2_ENST00000321382.3_Silent_p.R458R	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	458					heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CACCTGCCTTCCGTTCATCAG	0.512000													17	67					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18897384	18897384	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18897384C>T	ENST00000542601.2	-	10	1502	c.1113G>A	c.(1111-1113)ggG>ggA	p.G371G	COMP_ENST00000425807.1_Silent_p.G351G|COMP_ENST00000222271.2_Silent_p.G404G			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	404			C -> S (in EDM1; Fairbank type).		anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						CACAGGCATCCCCTATACCAT	0.582000													14	54					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220312757	220312757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220312757G>A	ENST00000312358.7	+	4	1009	c.877G>A	c.(877-879)Gaa>Aaa	p.E293K	SPEG_ENST00000396698.1_Missense_Mutation_p.E189K|SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396695.2_5'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	293	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ACTGGCCAGCGAAGCCCCACG	0.706000													8	27					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10514928	10514928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10514928G>A	ENST00000444303.2	+	6	967	c.495G>A	c.(493-495)atG>atA	p.M165I	AMPD3_ENST00000396554.3_Missense_Mutation_p.M333I	NM_001172431.1	NP_001165902.1	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3	324					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CCGCCTGCATGAACCAAAAGC	0.597000													41	142					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68699036	68699036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68699036G>A	ENST00000283916.6	-	7	676	c.578C>T	c.(577-579)gCt>gTt	p.A193V	TMPRSS11D_ENST00000509584.1_5'UTR|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11D_ENST00000545541.1_Missense_Mutation_p.A76V	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	193	Peptidase S1.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						TCCCTCCTCAGCCTCAGTGCC	0.522000													47	151					0	0	1	0	0
ZNF418	147686	broad.mit.edu	37	19	58438240	58438240	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58438240G>A	ENST00000396147.1	-	4	1600	c.1309C>T	c.(1309-1311)Cga>Tga	p.R437*	ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000595830.1_Nonsense_Mutation_p.R437*|ZNF418_ENST00000425570.3_Nonsense_Mutation_p.R458*|ZNF418_ENST00000599852.1_Nonsense_Mutation_p.R352*	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TTGCCCTTTCGACTAAAAGAT	0.468000													69	211					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107012559	107012559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:107012559C>T	ENST00000369701.3	+	23	3359	c.3132C>T	c.(3130-3132)atC>atT	p.I1044I		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1044						integral to membrane	neuropeptide receptor activity	p.I1044I(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGGACCAGATCCTCATTGCCG	0.527000													46	98					0	0	1	0	0
CD200R1L	344807	broad.mit.edu	37	3	112545989	112545989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112545989C>T	ENST00000488794.1	-	6	1056	c.467G>A	c.(466-468)gGa>gAa	p.G156E	CD200R1L_ENST00000448932.1_Missense_Mutation_p.G156E|CD200R1L_ENST00000398214.1_Missense_Mutation_p.G177E			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	177	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						AAGAATAGATCCCTCTGGGAT	0.507000													13	35					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110489561	110489561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110489561G>A	ENST00000378402.5	+	53	9129	c.9025G>A	c.(9025-9027)Gat>Aat	p.D3009N		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3009					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATTCTCCAGGATTGCTTTCC	0.408000										HNSCC(38;0.096)			19	52					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36257174	36257174	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36257174C>T	ENST00000296604.3	-	10	1258		c.e10-1		RANBP3L_ENST00000502994.1_Splice_Site|RANBP3L_ENST00000515759.1_Splice_Site	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like						intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GAGTCTGTTCCTAAGAGAAAA	0.368000													19	78					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78340231	78340231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78340231G>A	ENST00000255189.3	-	6	918	c.890C>T	c.(889-891)tCa>tTa	p.S297L	DMGDH_ENST00000380311.4_Missense_Mutation_p.S96L|DMGDH_ENST00000540686.1_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	297					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		GAGATAATATGATCCTTCCAG	0.438000													45	107					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156496304	156496304	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156496304G>A	ENST00000361170.2	-	38	4880	c.4870C>T	c.(4870-4872)Ctc>Ttc	p.L1624F		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1624					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTCTTGTTGAGGAGGAAGATG	0.488000													13	52					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28918362	28918362	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28918362G>A	ENST00000257192.4	+	10	1562	c.1350G>A	c.(1348-1350)aaG>aaA	p.K450K		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	450	Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AAGTTACCAAGGAACAGTACA	0.338000													21	68					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75900468	75900468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:75900468G>A	ENST00000377636.3	-	10	2244	c.1898C>T	c.(1897-1899)tCc>tTc	p.S633F	TBC1D4_ENST00000431480.2_Missense_Mutation_p.S633F|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000377625.2_Missense_Mutation_p.S633F	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	633						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AAACTGCGGGGAGTCGGAATC	0.582000													16	44					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17539536	17539536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17539536C>T	ENST00000229922.2	+	8	1205	c.673C>T	c.(673-675)Ctc>Ttc	p.L225F	CAP2_ENST00000493172.1_Intron|CAP2_ENST00000465994.1_Missense_Mutation_p.L161F|CAP2_ENST00000489374.1_Missense_Mutation_p.L113F|CAP2_ENST00000378990.2_Missense_Mutation_p.L199F	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	225					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			GTTTTCTGTCCTCTCCTCTGG	0.552000													34	180					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26825586	26825586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:26825586C>T	ENST00000541819.2	-	7	832	c.730G>A	c.(730-732)Gac>Aac	p.D244N	GABRB3_ENST00000545868.1_Missense_Mutation_p.D103N|GABRB3_ENST00000299267.4_Missense_Mutation_p.D188N|GABRB3_ENST00000311550.5_Missense_Mutation_p.D188N|GABRB3_ENST00000400188.3_Missense_Mutation_p.D117N			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	188					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AACTCAATGTCATCCGTGGTG	0.507000													30	80					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8808591	8808591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8808591C>T	ENST00000324436.3	-	1	581	c.461G>A	c.(460-462)aGc>aAc	p.S154N		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	154						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						GGTGGCCGGGCTGAAGGGTGG	0.672000													20	56					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13749204	13749204	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:13749204C>T	ENST00000532502.1	+	2	2059	c.231C>T	c.(229-231)ctC>ctT	p.L77L	FAR1_ENST00000354817.3_Silent_p.L453L			Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	453					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						TGTCTGGCCTCCCTGCAGCCA	0.383000													24	93					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73042718	73042718	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73042718G>A	ENST00000604411.1	+	0	30679				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCTACTCAATGAAGTTTCTTC	0.353000													17	13					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212745	62212745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:62212745G>A	ENST00000519846.1	+	3	831	c.359G>A	c.(358-360)aGg>aAg	p.R120K	CLVS1_ENST00000325897.4_Missense_Mutation_p.R120K|RP11-787D18.1_ENST00000518064.1_RNA|CLVS1_ENST00000518592.1_Intron			Q8IUQ0	CLVS1_HUMAN	clavesin 1	120	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						GGCATTAAGAGGGCTCTGATC	0.502000													23	42					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209803966	209803966	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209803966A>T	ENST00000391911.1	-	8	1326	c.937T>A	c.(937-939)Tgc>Agc	p.C313S	LAMB3_ENST00000356082.4_Missense_Mutation_p.C313S|LAMB3_ENST00000367030.3_Missense_Mutation_p.C313S	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	313	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CTACTTTGGCATTCATGGGCG	0.617000													21	64					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82834820	82834820	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82834820C>T	ENST00000265077.3	+	8	6563	c.5998C>T	c.(5998-6000)Ccc>Tcc	p.P2000S	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.P1013S|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2000	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTCAGCCTTCCCCTGGGAAGA	0.512000													22	54					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96970493	96970493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96970493C>T	ENST00000341686.3	+	5	823	c.698C>T	c.(697-699)cCc>cTc	p.P233L	C10orf129_ENST00000394005.3_Missense_Mutation_p.P233L|C10orf129_ENST00000430183.1_Missense_Mutation_p.P78L	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	233					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		ACAGGAGCTCCCAAAATGGTC	0.507000													24	57					0	0	1	0	0
ZFP41	286128	broad.mit.edu	37	8	144332487	144332487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144332487C>T	ENST00000330701.4	+	2	843	c.474C>T	c.(472-474)ctC>ctT	p.L158L	ZFP41_ENST00000522452.1_Silent_p.L158L|ZFP41_ENST00000520584.1_Silent_p.L158L	NM_173832.3	NP_776193.1	Q8N8Y5	ZFP41_HUMAN	ZFP41 zinc finger protein	158					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|lung(4)|ovary(1)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GCTCCAATCTCCTGAAACATC	0.562000													52	117					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810712	65810712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65810712C>T	ENST00000312006.4	-	3	843	c.562G>A	c.(562-564)Gag>Aag	p.E188K	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.E188K	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	188					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						TAGTATGCCTCGGGCGCGCGC	0.677000													11	38					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196642646	196642646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196642646C>T	ENST00000312428.6	-	59	11042	c.10942G>A	c.(10942-10944)Gat>Aat	p.D3648N	DNAH7_ENST00000409063.1_Missense_Mutation_p.D131N	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3648					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.D3648N(1)		NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCCAGTCATCGGTCACTCTG	0.473000													17	54					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171173122	171173122	+	Missense_Mutation	SNP	G	G	A	rs147029269	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171173122G>A	ENST00000441535.1	+	6	863	c.746G>A	c.(745-747)cGa>cAa	p.R249Q	RP1-127D3.4_ENST00000422841.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000209929.7_Missense_Mutation_p.R249Q|RP1-127D3.4_ENST00000445290.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	249					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTACTGCCACGAACAGCTGTA	0.453000													22	61					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57349320	57349320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57349320C>T	ENST00000361249.3	+	6	917	c.821C>T	c.(820-822)tCa>tTa	p.S274L		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	274	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CAAGACACTTCATTCTTGAAC	0.403000													15	51					0	0	1	0	0
CECR5	27440	broad.mit.edu	37	22	17624020	17624020	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17624020G>A	ENST00000336737.4	-	5	564	c.537_splice	c.e5-1	p.P180_splice	CECR5_ENST00000155674.5_Splice_Site_p.P150_splice|CECR5_ENST00000399852.3_Splice_Site_p.P43_splice	NM_033070.2	NP_149061.1	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	180							hydrolase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(10)|pancreas(1)|prostate(1)	21		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				CCTCGGGAGGGGCTGCAGAGA	0.577000													10	45					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66322807	66322807	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66322807C>T	ENST00000513398.1	+	0	784				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						CAGAGAAATACCTGGACATCC	0.562000													22	89					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21690356	21690356	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21690356G>A	ENST00000388958.3	+	3	121		c.e3-1		OTOA_ENST00000286149.4_Splice_Site	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin						sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		TTGCCTTTTAGGAAGAAATAA	0.383000													24	200					0	0	1	0	0
U2AF1L4	199746	broad.mit.edu	37	19	36233574	36233574	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36233574G>A	ENST00000292879.5	-	6	587	c.534C>T	c.(532-534)tcC>tcT	p.S178S	AD000671.6_ENST00000589807.1_Intron|U2AF1L4_ENST00000412391.2_3'UTR|U2AF1L4_ENST00000378975.3_3'UTR	NM_144987.2	NP_659424.2	Q8WU68	U2AF4_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 4	0					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	8	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGTCCTGCCAGGAACATCTGT	0.597000													28	103					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138453098	138453098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138453098C>T	ENST00000344876.4	-	1	531	c.145G>A	c.(145-147)Gag>Aag	p.E49K	PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.E49K|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	49	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					GCCACATCCTCTGATAGTCTT	0.408000													34	87					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218305	130218305	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130218305G>A	ENST00000276211.5	+	5	1017	c.672G>A	c.(670-672)agG>agA	p.R224R	ARHGAP36_ENST00000370921.1_Silent_p.R88R|ARHGAP36_ENST00000370922.1_Silent_p.R212R	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	224					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GATCCAAAAGGAAGATGAGTC	0.478000													26	12					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2297376	2297376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2297376G>A	ENST00000222990.3	-	8	1020	c.978C>T	c.(976-978)tcC>tcT	p.S326S		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	326					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		TCACCTTATAGGACTGCAGCA	0.567000													67	273					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123887067	123887067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123887067C>T	ENST00000320891.4	+	1	786	c.786C>T	c.(784-786)ggC>ggT	p.G262G		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGAGGCCAGGCTCCATGGATG	0.522000													15	60					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76777849	76777849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:76777849G>A	ENST00000373344.5	-	32	7081	c.6867C>T	c.(6865-6867)ttC>ttT	p.F2289F	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Silent_p.F2251F	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2289					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TTGGTATGTTGAAACGCATGG	0.368000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						39	27					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124397119	124397119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124397119C>T	ENST00000360013.3	+	50	7403	c.7276C>T	c.(7276-7278)Cgt>Tgt	p.R2426C	KALRN_ENST00000428018.2_Missense_Mutation_p.R697C|KALRN_ENST00000291478.4_Missense_Mutation_p.R729C|KALRN_ENST00000462213.1_Missense_Mutation_p.R43C	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2425					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CACAGGGCCTCGTAAACCCAA	0.498000													27	100					0	0	1	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19564139	19564139	+	Silent	SNP	G	G	A	rs148651015	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:19564139G>A	ENST00000397821.3	-	15	1814	c.1524C>T	c.(1522-1524)gaC>gaT	p.D508D	SH3KBP1_ENST00000379698.4_Silent_p.D471D|SH3KBP1_ENST00000379716.1_Silent_p.D270D|SH3KBP1_ENST00000541422.1_Silent_p.D247D	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	508					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						GACTTGGGGAGTCGAAGATAT	0.433000													19	16					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94700041	94700041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94700041C>T	ENST00000304338.3	+	6	722	c.568C>T	c.(568-570)Cgt>Tgt	p.R190C		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	190						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AGTCCAGTCTCGTTTAGTTAG	0.303000													39	111					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157985168	157985168	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157985168C>T	ENST00000389413.3	-	5	503	c.400G>A	c.(400-402)Ggc>Agc	p.G134S	PTPRN2_ENST00000409483.1_Missense_Mutation_p.G96S|PTPRN2_ENST00000404321.2_Missense_Mutation_p.G157S|PTPRN2_ENST00000389416.4_Missense_Mutation_p.G117S|PTPRN2_ENST00000389418.4_Missense_Mutation_p.G134S	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	134						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CTCTCGCTGCCAACGCTGTGT	0.637000													18	86					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	994959	994959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:994959C>T	ENST00000537687.1	+	19	6412	c.5769C>T	c.(5767-5769)ttC>ttT	p.F1923F	WNK1_ENST00000530271.2_Silent_p.F2161F|WNK1_ENST00000340908.4_Silent_p.F1256F|WNK1_ENST00000535572.1_Silent_p.F1416F|WNK1_ENST00000315939.6_Silent_p.F1663F	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1663					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GGTCTCTGTTCAGTGAACACA	0.483000													21	60					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9389291	9389291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9389291C>T	ENST00000378501.2	+	19	1780	c.1765C>T	c.(1765-1767)Cat>Tat	p.H589Y	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.H601Y|PLCB4_ENST00000278655.4_Missense_Mutation_p.H589Y|PLCB4_ENST00000378493.1_Missense_Mutation_p.H589Y|PLCB4_ENST00000334005.3_Missense_Mutation_p.H589Y|PLCB4_ENST00000378473.3_Missense_Mutation_p.H601Y	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	589	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						ACGCAATATTCATTATAACAT	0.358000													7	24					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11718434	11718434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11718434C>T	ENST00000381486.2	+	6	949	c.649C>T	c.(649-651)Cgg>Tgg	p.R217W	GREB1_ENST00000263834.5_Missense_Mutation_p.R217W|GREB1_ENST00000234142.5_Missense_Mutation_p.R217W|GREB1_ENST00000389825.3_Missense_Mutation_p.R107W|GREB1_ENST00000381483.2_Missense_Mutation_p.R217W	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	217						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GTTTAGAAGCCGGCAGATCCC	0.577000													79	131					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10357094	10357094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10357094C>T	ENST00000255381.2	-	23	2910	c.2800G>A	c.(2800-2802)Gaa>Aaa	p.E934K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	934					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTGATCTCTTCCTCATCCTCA	0.443000													110	247					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49668450	49668450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49668450C>T	ENST00000339139.4	-	5	350	c.114G>A	c.(112-114)agG>agA	p.R38R		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	38						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTACAATCTCCCTTTGCACTT	0.363000													25	88					0	0	1	0	0
CSN2	1447	broad.mit.edu	37	4	70823435	70823435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70823435G>A	ENST00000353151.3	-	5	243	c.232C>T	c.(232-234)Cca>Tca	p.P78S		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	78					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						ATGTTTTGTGGAAGAAAACCA	0.468000													29	111					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177036456	177036456	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:177036456G>A	ENST00000468418.3	+	4	2843	c.753G>A	c.(751-753)aaG>aaA	p.K251K	HOXD3_ENST00000249440.3_Silent_p.K251K|HOXD3_ENST00000410016.1_Silent_p.K251K			P31249	HXD3_HUMAN	homeobox D3	251					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGTACAAGAAGGACCAGAAGG	0.662000													37	89					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38903382	38903382	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38903382G>A	ENST00000359357.3	+	75	11075	c.10821G>A	c.(10819-10821)gaG>gaA	p.E3607E	DNAH8_ENST00000441566.1_Silent_p.E3571E|DNAH8_ENST00000449981.2_Silent_p.E3824E|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TAGAGGCTGAGAGGGTTAAAC	0.313000													93	200					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15234464	15234464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:15234464C>T	ENST00000395930.1	-	3	625	c.439G>A	c.(439-441)Gga>Aga	p.G147R	TEKT3_ENST00000338696.2_Missense_Mutation_p.G147R	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	147					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		ACACGTTCTCCCAGATTTTGG	0.388000													30	51					0	0	1	0	0
FCER2	2208	broad.mit.edu	37	19	7755310	7755310	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7755310G>A	ENST00000346664.5	-	9	815	c.603C>T	c.(601-603)atC>atT	p.I201I	FCER2_ENST00000360067.4_Silent_p.I200I|FCER2_ENST00000597921.1_Silent_p.I201I	NM_001220500.1|NM_002002.4	NP_001207429.1|NP_001993.2	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor for (CD23)	201	C-type lectin.				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10						CCGGGCTGTGGATGCTGACCA	0.637000													17	53					0	0	1	0	0
OR5P2	120065	broad.mit.edu	37	11	7817655	7817655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7817655G>A	ENST00000329434.2	-	1	865	c.835C>T	c.(835-837)Ccc>Tcc	p.P279S	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTCAACATGGGAATCACCACT	0.438000													30	107					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139151280	139151280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139151280C>T	ENST00000395297.1	-	18	4020	c.3850G>A	c.(3850-3852)Gat>Aat	p.D1284N		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1284										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCAGCATTATCCCTGAAGGTC	0.423000										HNSCC(54;0.14)			27	72					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210560616	210560616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:210560616C>T	ENST00000360351.4	+	7	4228	c.3722C>T	c.(3721-3723)gCc>gTc	p.A1241V	MAP2_ENST00000361559.4_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.A1237V|MAP2_ENST00000199940.6_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1241					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GAGATAGAAGCCCAGGGAGAA	0.493000													8	56					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123283252	123283252	+	Silent	SNP	C	C	T	rs35817975		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123283252C>T	ENST00000264501.4	+	86	15241	c.14868C>T	c.(14866-14868)ggC>ggT	p.G4956G	KIAA1109_ENST00000388738.3_Silent_p.G4956G			Q2LD37	K1109_HUMAN	KIAA1109	4956					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AAAAATTGGGCTTTCATCATG	0.353000													29	166					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44114596	44114596	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44114596C>T	ENST00000259746.9	+	11	978	c.795C>T	c.(793-795)ccC>ccT	p.P265P	TMEM63B_ENST00000323267.6_Silent_p.P265P			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	265						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			AAGCCTACCCCAACTGCACAG	0.562000													33	70					0	0	1	0	0
C1QA	712	broad.mit.edu	37	1	22965719	22965719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22965719C>T	ENST00000374642.3	+	3	761	c.557C>T	c.(556-558)tCc>tTc	p.S186F	C1QA_ENST00000402322.1_Missense_Mutation_p.S186F	NM_015991.2	NP_057075.1	P02745	C1QA_HUMAN	complement component 1, q subcomponent, A chain	186	C1q.				cell-cell signaling|complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				autonomic_ganglia(1)|liver(1)|lung(3)|skin(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.41e-27)|Colorectal(126;1.52e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.63e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000541)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GTCCGACGCTCCCTGGGCTTC	0.592000													14	63					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145627780	145627780	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:145627780G>A	ENST00000296575.3	+	5	1584	c.929G>A	c.(928-930)tGg>tAg	p.W310*		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	310						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		CAAGAACGGTGGGCTATCGGG	0.433000													16	35					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25349830	25349830	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25349830G>A	ENST00000546682.1	+	0	2300				SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000516123.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TGGAATCTGAGCAAAACGAGT	0.463000													20	88					0	0	1	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642706	1642706	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1642706G>A	ENST00000399682.1	-	1	662	c.618C>T	c.(616-618)tcC>tcT	p.S206S		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	266	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGCAGCAACTGGACTGGCAGC	0.597000													74	144					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221279	161221279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161221279G>A	ENST00000327928.4	+	4	983	c.983G>A	c.(982-984)cGg>cAg	p.R328Q		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	328	Collagen-like 3.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AAGGGCTCTCGGGGCTTTAAA	0.572000													7	16					0	0	1	0	0
APPL1	26060	broad.mit.edu	37	3	57272128	57272128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:57272128C>T	ENST00000288266.3	+	4	416	c.269C>T	c.(268-270)tCa>tTa	p.S90L		NM_012096.2	NP_036228.1	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	90	Required for RAB5A binding.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(10)|liver(2)|lung(4)|prostate(2)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		CAACAGTTTTCAAAAGTTATA	0.328000													19	45					0	0	1	0	0
SIAE	54414	broad.mit.edu	37	11	124530644	124530644	+	Silent	SNP	G	G	A	rs147638217		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124530644G>A	ENST00000263593.3	-	3	457	c.285C>T	c.(283-285)ttC>ttT	p.F95F	SIAE_ENST00000545756.1_Silent_p.F60F			Q9HAT2	SIAE_HUMAN	sialic acid acetylesterase	95						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	15	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		CCATCACTTCGAAAGGTCCTC	0.443000													80	183					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77407038	77407038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77407038G>A	ENST00000560626.2	-	7	5176	c.4701C>T	c.(4699-4701)gaC>gaT	p.D1567D	PEAK1_ENST00000312493.4_Silent_p.D1567D			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1567	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										GGATCTCGGGGTCCACCAGAT	0.537000													44	149					0	0	1	0	0
MKKS	8195	broad.mit.edu	37	20	10393713	10393713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:10393713G>A	ENST00000347364.2	-	3	1212	c.450C>T	c.(448-450)ctC>ctT	p.L150L		NM_170784.2	NP_740754.1	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome	150					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding			kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|stomach(2)	16						CCAAACAAAGGAGGATCTGAG	0.408000													34	83					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52475669	52475669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52475669C>T	ENST00000231721.2	-	6	587	c.588G>A	c.(586-588)ctG>ctA	p.L196L		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	196	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CCTCTCGCCCCAGGAAGTCAG	0.657000													6	78					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98763931	98763931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98763931G>A	ENST00000266058.4	-	34	4004	c.3759C>T	c.(3757-3759)gcC>gcT	p.A1253A	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.A1253A	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1253	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TCTGGTCAAAGGCAACCAGCT	0.557000													47	208					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124743205	124743205	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124743205G>A	ENST00000397801.1	+	10	1728		c.e10-1		ROBO3_ENST00000538940.1_Splice_Site	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)						axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTCTCTTCCAGGAGATGGACA	0.552000													9	10					0	0	1	0	0
MRPL51	51258	broad.mit.edu	37	12	6601548	6601548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6601548G>A	ENST00000229238.3	-	3	737	c.276C>T	c.(274-276)atC>atT	p.I92I	MRPL51_ENST00000543164.1_5'UTR|MRPL51_ENST00000543703.1_5'UTR	NM_016497.3	NP_057581.2	Q4U2R6	RM51_HUMAN	mitochondrial ribosomal protein L51	92					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome			kidney(2)|large_intestine(1)|lung(3)	6						TCCTCTTTCGGATACAACGTT	0.443000													88	283					0	0	1	0	0
METTL21C	196541	broad.mit.edu	37	13	103343261	103343261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:103343261C>T	ENST00000267273.6	-	2	189	c.184G>A	c.(184-186)Gat>Aat	p.D62N		NM_001010977.1	NP_001010977.1	Q5VZV1	MT21C_HUMAN	methyltransferase like 21C	62							methyltransferase activity			breast(1)|large_intestine(3)|lung(2)|skin(1)	7						CTGGCGTAATCTGTAGGAACA	0.438000													8	104					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179664562	179664562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179664562C>T	ENST00000589042.1	-	5	883	c.659G>A	c.(658-660)cGa>cAa	p.R220Q	TTN_ENST00000342992.6_Missense_Mutation_p.R220Q|TTN_ENST00000360870.5_Missense_Mutation_p.R220Q|TTN_ENST00000591111.1_Missense_Mutation_p.R220Q|TTN_ENST00000342175.6_Missense_Mutation_p.R220Q|TTN_ENST00000359218.5_Missense_Mutation_p.R220Q|TTN_ENST00000460472.2_Missense_Mutation_p.R220Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	220							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R220P(6)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTTCAATTCGGGTTTGTCT	0.403000													22	47					0	0	1	0	0
PRKG1	5592	broad.mit.edu	37	10	54031199	54031199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:54031199C>T	ENST00000373980.4	+	11	1680	c.1263C>T	c.(1261-1263)atC>atT	p.I421I	PRKG1_ENST00000401604.2_Silent_p.I406I|PRKG1_ENST00000373975.2_Silent_p.I124I|PRKG1-AS1_ENST00000426785.2_RNA|PRKG1_ENST00000373985.1_Silent_p.I394I|PRKG1-AS1_ENST00000452247.2_RNA	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	406	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		AGGAGCACATCCGCTCAGAGA	0.463000													13	45					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213419	9213419	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9213419G>A	ENST00000305456.2	-	1	563	c.564C>T	c.(562-564)tcC>tcT	p.S188S		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						CTGTGCAGAAGGACAGCCTCA	0.493000													27	50					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20141286	20141286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20141286C>T	ENST00000375121.2	-	1	485	c.309G>A	c.(307-309)gaG>gaA	p.E103E	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	103						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCACCGCCTCATGGTCGC	0.672000													15	71					0	0	1	0	0
ACVR1	90	broad.mit.edu	37	2	158634709	158634709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158634709G>A	ENST00000263640.3	-	5	906	c.477C>T	c.(475-477)ccC>ccT	p.P159P	ACVR1_ENST00000487456.1_5'UTR|ACVR1_ENST00000410057.2_Silent_p.P159P|ACVR1_ENST00000409283.2_Silent_p.P159P|ACVR1_ENST00000434821.1_Silent_p.P159P	NM_001105.4	NP_001096.1	Q04771	ACVR1_HUMAN	activin A receptor, type I	159					BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	19				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	CCACGTCTCGGGGATTGAGGC	0.483000													16	40					0	0	1	0	0
RNF14	9604	broad.mit.edu	37	5	141359747	141359747	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141359747C>A	ENST00000394520.2	+	6	1203	c.894C>A	c.(892-894)tcC>tcA	p.S298S	RNF14_ENST00000356143.1_Silent_p.S298S|RNF14_ENST00000347642.3_Silent_p.S298S|RNF14_ENST00000540015.1_Intron|RNF14_ENST00000394519.1_Silent_p.S298S|AC005740.5_ENST00000520882.1_RNA|RNF14_ENST00000394514.2_Silent_p.S172S|RNF14_ENST00000394515.3_Silent_p.S122S	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	298					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		TCCTCCAGTCCTCCTTGGACC	0.542000													41	185					2.24722e-20	2.26093e-20	1	1	0
PGLYRP3	114771	broad.mit.edu	37	1	153276337	153276337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153276337C>T	ENST00000290722.1	-	4	577	c.525G>A	c.(523-525)agG>agA	p.R175R		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	175					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCTTACCCTTCCTGGGCATCA	0.537000													29	72					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424154	125424154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125424154C>T	ENST00000373686.1	+	1	310	c.310C>T	c.(310-312)Cgt>Tgt	p.R104C				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						CTCAGACACTCGTCTCCAGAC	0.468000													45	95					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31606007	31606007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31606007C>T	ENST00000379416.3	-	11	946	c.898G>A	c.(898-900)Gga>Aga	p.G300R	XDH_ENST00000491727.1_5'UTR	NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	300	FAD-binding PCMH-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CAAGCAGCTCCAAAGGAGATA	0.522000													17	51					0	0	1	0	0
CA9	768	broad.mit.edu	37	9	35679199	35679199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35679199C>T	ENST00000378357.4	+	7	1029	c.925C>T	c.(925-927)Cca>Tca	p.P309S	CA9_ENST00000493245.1_3'UTR	NM_001216.2	NP_001207.2	Q16790	CAH9_HUMAN	carbonic anhydrase IX	309	Catalytic.				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	17	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GACTCAGGTCCCAGGACTGGA	0.537000													24	258					0	0	1	0	0
IL11RA	3590	broad.mit.edu	37	9	34660551	34660551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34660551C>T	ENST00000555003.1	+	11	2479	c.1123C>T	c.(1123-1125)Ctt>Ttt	p.L375F	IL11RA_ENST00000602473.1_Missense_Mutation_p.L375F|IL11RA_ENST00000378817.4_Missense_Mutation_p.L375F|IL11RA_ENST00000441545.2_Missense_Mutation_p.L375F|IL11RA_ENST00000318041.9_Missense_Mutation_p.L375F			Q14626	I11RA_HUMAN	interleukin 11 receptor, alpha	375						integral to plasma membrane	cytokine receptor activity			breast(1)|large_intestine(1)|ovary(1)|skin(1)	4	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.174)	Oprelvekin(DB00038)	TTTGGGAATCCTTTCTTTCCT	0.592000													11	36					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20296056	20296056	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20296056T>C	ENST00000568211.1	+	1	449	c.449T>C	c.(448-450)cTt>cCt	p.L150P	OR4N2_ENST00000315947.1_Missense_Mutation_p.L150P			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTCTGTGGCTTGGGGGTTTT	0.532000													73	153					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28647982	28647982	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28647982C>T	ENST00000280904.6	-	16	3148	c.2705G>A	c.(2704-2706)tGa>tAa	p.*902*	DSC2_ENST00000251081.6_3'UTR	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	0					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			AGAACACACTCATCTCTTCAT	0.373000													9	47					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197446859	197446859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197446859G>A	ENST00000367400.3	+	12	4206	c.4071G>A	c.(4069-4071)ctG>ctA	p.L1357L	CRB1_ENST00000544212.1_Silent_p.L838L|CRB1_ENST00000538660.1_Silent_p.L821L|CRB1_ENST00000367399.2_Silent_p.L1245L|CRB1_ENST00000535699.1_Silent_p.L1333L	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1357					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCTTGTTACTGATCCTCTTGC	0.502000													10	53					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28362215	28362215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28362215G>A	ENST00000261609.7	-	87	13466	c.13358C>T	c.(13357-13359)tCg>tTg	p.S4453L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4453					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GGGACCAAACGAGCTCATCTT	0.592000													5	40					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110476877	110476877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110476877G>A	ENST00000378402.5	+	49	7920	c.7816G>A	c.(7816-7818)Gtt>Att	p.V2606I		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2606					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCAAAAAAGAGTTCCCCTTGG	0.438000										HNSCC(38;0.096)			13	95					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51728689	51728689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51728689G>A	ENST00000262262.4	+	2	274	c.253G>A	c.(253-255)Gag>Aag	p.E85K	CD33_ENST00000436584.2_Intron|CD33_ENST00000391796.3_Missense_Mutation_p.E85K|CD33_ENST00000421133.2_Intron	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	85	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AGTACAGGAGGAGACTCAGGG	0.522000													26	96					0	0	1	0	0
ERO1L	30001	broad.mit.edu	37	14	53149110	53149110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:53149110G>A	ENST00000395686.3	-	3	474	c.251C>T	c.(250-252)cCg>cTg	p.P84L		NM_014584.1	NP_055399.1	Q96HE7	ERO1A_HUMAN	ERO1-like (S. cerevisiae)	84					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor		ERO1L/FERMT2(2)	breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12	Breast(41;0.226)					GAAAGGACACGGCCTCTTCAG	0.333000													35	106					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57641207	57641207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57641207G>A	ENST00000254181.4	+	4	1618	c.1164G>A	c.(1162-1164)atG>atA	p.M388I	USP29_ENST00000598197.1_Missense_Mutation_p.M388I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	388					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAGAAGACATGGAAAAATTAA	0.378000													34	75					0	0	1	0	0
FOXI2	399823	broad.mit.edu	37	10	129536979	129536979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129536979C>T	ENST00000388920.4	+	2	746	c.707C>T	c.(706-708)cCa>cTa	p.P236L		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	236					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				TCGCCCTCTCCATCCGCACCC	0.751000													4	16					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55048253	55048253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55048253G>A	ENST00000335056.3	+	5	858	c.820G>A	c.(820-822)Gaa>Aaa	p.E274K	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GAGACACAGGGAAGCATTCCA	0.547000													44	100					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	514923	514923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:514923C>T	ENST00000453061.2	+	7	1299	c.1193C>T	c.(1192-1194)tCa>tTa	p.S398L	PIGG_ENST00000310340.5_Missense_Mutation_p.S398L|PIGG_ENST00000383028.4_Missense_Mutation_p.S265L|PIGG_ENST00000503111.1_Intron|PIGG_ENST00000509768.1_Missense_Mutation_p.S309L|PIGG_ENST00000536264.1_Missense_Mutation_p.S276L|PIGG_ENST00000296306.7_Intron|PIGG_ENST00000504346.1_Missense_Mutation_p.S309L	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	398					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						GAAAAGCATTCAGAAGTCCTA	0.473000													33	87					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128651888	128651888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128651888G>A	ENST00000344954.6	+	5	914	c.526G>A	c.(526-528)Gac>Aac	p.D176N	FLI1_ENST00000429175.2_Missense_Mutation_p.D209N|FLI1_ENST00000525560.1_Missense_Mutation_p.D16N|FLI1_ENST00000281428.8_Missense_Mutation_p.D143N|FLI1_ENST00000534087.1_Missense_Mutation_p.D176N			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	209	PNT.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		CTCCCACACCGACCAATCCTC	0.413000			T	EWSR1	Ewing sarcoma								34	89					0	0	1	0	0
CD81	975	broad.mit.edu	37	11	2415372	2415372	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2415372T>G	ENST00000263645.5	+	3	485	c.229T>G	c.(229-231)Ttc>Gtc	p.F77V	CD81_ENST00000381036.3_Missense_Mutation_p.F115V|CD81_ENST00000492627.1_Missense_Mutation_p.F6V|CD81_ENST00000526072.1_Missense_Mutation_p.F6V|CD81_ENST00000524805.1_3'UTR|CD81_ENST00000481687.1_Missense_Mutation_p.F83V	NM_004356.3	NP_004347.1	P60033	CD81_HUMAN	CD81 molecule	77					activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding			endometrium(1)|lung(3)|skin(1)	5		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTTCGTTGGCTTCCTGGGCTG	0.662000													18	47					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193120444	193120444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:193120444G>A	ENST00000342695.4	-	30	3910	c.3588C>T	c.(3586-3588)ctC>ctT	p.L1196L	ATP13A4_ENST00000392443.3_Silent_p.L1177L|ATP13A4_ENST00000482964.1_5'UTR|ATP13A4_ENST00000400270.2_Silent_p.L212L	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1196					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		ATGTCCTTCAGAGTTGTTCTT	0.433000													24	27					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207785317	207785317	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207785317C>T	ENST00000367049.4	+	39	6506	c.6506C>T	c.(6505-6507)cCt>cTt	p.P2169L	CR1_ENST00000400960.2_Missense_Mutation_p.P1719L|CR1_ENST00000367052.1_Missense_Mutation_p.P1719L|CR1_ENST00000367053.1_Missense_Mutation_p.P1719L|CR1_ENST00000367051.1_Missense_Mutation_p.P1719L	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1719					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity	p.P2169L(1)|p.P1724L(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GGCCAACTCCCTCATGGCCGT	0.483000													30	408					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41710281	41710281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41710281C>T	ENST00000400454.1	-	8	2007	c.1530G>A	c.(1528-1530)atG>atA	p.M510I		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	510	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGATGTTTTTCATTGGTCGAA	0.418000													13	52					0	0	1	0	0
URAD	646625	broad.mit.edu	37	13	28562602	28562602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28562602G>A	ENST00000332715.4	-	1	172	c.173C>T	c.(172-174)tCa>tTa	p.S58L		NM_001105577.1	NP_001099047.1			ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase																		AGCCTTACCTGACTGTGCAAG	0.433000													18	45					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239010666	239010666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239010666G>A	ENST00000343063.3	+	2	642	c.379G>A	c.(379-381)Ggc>Agc	p.G127S	ESPNL_ENST00000409169.1_Missense_Mutation_p.G127S	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	127										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GCTCCACGAGGGCCACTCGGC	0.701000													3	17					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739539	55739539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55739539C>T	ENST00000370830.3	-	1	823	c.125G>A	c.(124-126)aGa>aAa	p.R42K	BMP5_ENST00000446683.2_Missense_Mutation_p.R42K	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	42					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GTTCCGTAGTCTTCTATAAAT	0.453000													62	173					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105207212	105207212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105207212C>T	ENST00000332972.5	+	7	909	c.750C>T	c.(748-750)ttC>ttT	p.F250F	ADSSL1_ENST00000330877.2_Silent_p.F207F	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	207					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	AGTCGATGTTCCCCACCCTGG	0.602000													17	294					0	0	1	0	0
CENPH	64946	broad.mit.edu	37	5	68492933	68492933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:68492933C>T	ENST00000283006.2	+	5	455	c.368C>T	c.(367-369)tCt>tTt	p.S123F	CENPH_ENST00000515001.1_Intron	NM_022909.3	NP_075060.1	Q9H3R5	CENPH_HUMAN	centromere protein H	123					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|kinetochore organization|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	kinetochore binding|protein binding			kidney(15)|large_intestine(2)|lung(3)	20		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.41e-56)|Epithelial(20;1.29e-52)|all cancers(19;3.15e-48)|Lung(70;0.0178)		AGCAGACAGTCTAGGTATGAT	0.328000													14	55					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15580492	15580492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15580492G>A	ENST00000292609.4	-	4	1721	c.1592C>T	c.(1591-1593)cCc>cTc	p.P531L	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.P531L			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	531					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						CGCGTCGCCGGGGCAGTCGGT	0.726000													5	12					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49825032	49825032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:49825032C>T	ENST00000451037.2	-	4	1366	c.426G>A	c.(424-426)ggG>ggA	p.G142G	CA10_ENST00000442502.2_Silent_p.G142G|CA10_ENST00000340813.6_Silent_p.G148G|CA10_ENST00000570565.1_Silent_p.G67G|CA10_ENST00000285273.4_Silent_p.G142G|CA10_ENST00000571918.1_5'UTR	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	142					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GGTGCTCCGACCCTTGGCTGT	0.507000													57	131					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202446915	202446915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202446915C>T	ENST00000439140.1	-	5	586	c.542G>A	c.(541-543)cGg>cAg	p.R181Q	ALS2CR11_ENST00000286195.3_Missense_Mutation_p.R181Q|ALS2CR11_ENST00000450242.1_Missense_Mutation_p.R181Q|ALS2CR11_ENST00000439802.1_Missense_Mutation_p.R181Q	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	181										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						AATATTATTCCGCTTATCATC	0.303000													21	89					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11650885	11650885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11650885G>A	ENST00000262442.3	+	32	6480	c.6412G>A	c.(6412-6414)Gag>Aag	p.E2138K	DNAH9_ENST00000454412.2_Missense_Mutation_p.E2138K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2138	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGTCCAGCTGGAGGAGCTCCT	0.582000													15	12					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62995958	62995958	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62995958T>G	ENST00000306494.6	-	2	480	c.481A>C	c.(481-483)Aac>Cac	p.N161H	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A25_ENST00000403374.2_5'UTR	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	161					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CCATATAGGTTGCCTCCCACC	0.408000													25	66					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43865643	43865643	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43865643C>T	ENST00000378009.4	+	0	1154				CTC-490G23.4_ENST00000607109.1_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				GTGTGCAGCCCCTTGGAACCT	0.602000													9	69					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33623141	33623141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33623141C>T	ENST00000361680.2	+	1	144	c.66C>T	c.(64-66)tcC>tcT	p.S22S	WDR88_ENST00000355868.3_Silent_p.S22S|WDR88_ENST00000592765.1_Silent_p.S22S			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	22										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					CGCCACCCTCCGCCCCCGCCA	0.701000													8	72					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106208133	106208133	+	RNA	SNP	C	C	T	rs1803800		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106208133C>T	ENST00000390548.2	-	0	670																											CGGGGCTGCCCTGTAGGGACA	0.642000													59	178					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207870911	207870911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207870911C>T	ENST00000508064.2	+	6	986	c.926C>T	c.(925-927)tCa>tTa	p.S309L	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	309	Sushi 5.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GACAACTTTTCACCCGGGCAG	0.547000													69	200					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29039024	29039024	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29039024G>A	ENST00000257189.4	+	5	484	c.401G>A	c.(400-402)gGa>gAa	p.G134E		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	134	Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AATGCCCAAGGACTAGATGTA	0.328000													21	39					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29414516	29414516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:29414516G>A	ENST00000378993.1	+	4	1177	c.504G>A	c.(502-504)gaG>gaA	p.E168E	IL1RAPL1_ENST00000302196.4_Silent_p.E168E	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	168	Ig-like C2-type 2.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						GTGACATAGAGGATTTTCTAC	0.378000													58	49					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921362	24921362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24921362C>T	ENST00000329468.2	+	1	822	c.348C>T	c.(346-348)atC>atT	p.I116I		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCGTAAGGATCCCTCCTCCCA	0.657000													28	57					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20071504	20071504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20071504G>A	ENST00000245957.5	+	7	659	c.583G>A	c.(583-585)Gat>Aat	p.D195N	C20orf26_ENST00000377306.1_Missense_Mutation_p.D195N|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000451767.2_Missense_Mutation_p.D195N|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	195								p.D195N(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		AGACCATGACGATCTCATGCC	0.438000													36	197					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32332505	32332505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32332505G>A	ENST00000298386.2	+	2	276	c.205G>A	c.(205-207)Gat>Aat	p.D69N	RXFP2_ENST00000380314.1_Missense_Mutation_p.D69N	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	69	LDL-receptor class A.					integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TGATGGCAAGGATGACTGTGG	0.522000													46	129					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36580097	36580097	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:36580097C>T	ENST00000431169.1	-	16	1434	c.1133_splice	c.e16-1	p.G378_splice	AOAH_ENST00000535891.1_Splice_Site_p.G346_splice|AOAH_ENST00000258749.5_Splice_Site_p.G378_splice|AOAH_ENST00000538464.1_Splice_Site_p.G100_splice|AOAH_ENST00000491444.1_5'UTR	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	378					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity	p.G378G(1)		NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GGTCACTCTTCCTGTTGGTGG	0.463000													16	46					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52374652	52374652	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52374652C>T	ENST00000296585.5	+	24	3019	c.2876C>T	c.(2875-2877)tCa>tTa	p.S959L		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	959					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AATGTTCCTTCAATCGTGCAC	0.373000													17	42					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32259377	32259377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32259377C>T	ENST00000360482.2	-	12	2634	c.2505G>A	c.(2503-2505)agG>agA	p.R835R	SPOCD1_ENST00000533231.1_Silent_p.R835R|SPOCD1_ENST00000373648.2_3'UTR|SPOCD1_ENST00000257100.3_Silent_p.R328R	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	835					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GAGACAACTCCCTGGTTTTGG	0.592000													74	112					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45281205	45281205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45281205C>T	ENST00000270279.3	+	1	80	c.17C>T	c.(16-18)gCc>gTc	p.A6V	CBLC_ENST00000341505.4_Missense_Mutation_p.A6V	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	6					cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				CTGGCGGTGGCCCCGTGGGGG	0.716000			M		AML								9	15					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23830128	23830128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:23830128C>T	ENST00000264867.2	-	5	771	c.652G>A	c.(652-654)Gat>Aat	p.D218N	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	218					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GGAGGGTCATCGTTTGTGGTC	0.468000													54	170					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130290201	130290201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130290201G>A	ENST00000358511.6	+	6	2972	c.2941G>A	c.(2941-2943)Gat>Aat	p.D981N	COL6A6_ENST00000453409.2_Missense_Mutation_p.D981N	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	981	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AATATTTTCAGATGTGACAGC	0.433000													13	28					0	0	1	0	0
WNT8B	7479	broad.mit.edu	37	10	102240871	102240871	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102240871G>A	ENST00000343737.5	+	4	486	c.358G>A	c.(358-360)Ggg>Agg	p.G120R		NM_003393.3	NP_003384.2	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family, member 8B	120					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|large_intestine(1)|ovary(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		CTCCCGCAACGGGCAACTGGG	0.488000													30	53					0	0	1	0	0
WDR35	57539	broad.mit.edu	37	2	20169345	20169345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:20169345G>A	ENST00000345530.3	-	9	1019	c.904C>T	c.(904-906)Cct>Tct	p.P302S	WDR35_ENST00000416055.2_5'UTR|WDR35_ENST00000281405.4_Missense_Mutation_p.P302S	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	302										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTTTCCAGGAACTTTCAAA	0.338000													26	50					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8122528	8122528	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8122528C>T	ENST00000305253.4	+	12	1777	c.1536C>T	c.(1534-1536)atC>atT	p.I512I	TUB_ENST00000299506.2_Silent_p.I457I|TUB_ENST00000534099.1_Silent_p.I463I	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	457					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		ACTTCCAGATCATCCATGGCA	0.522000													18	76					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41542137	41542137	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41542137G>A	ENST00000396942.1	-	37	4545	c.4462C>T	c.(4462-4464)Cga>Tga	p.R1488*	ANK1_ENST00000289734.7_Nonsense_Mutation_p.R1488*|ANK1_ENST00000347528.4_Nonsense_Mutation_p.R1488*|ANK1_ENST00000379758.2_Nonsense_Mutation_p.R1488*|ANK1_ENST00000352337.4_Nonsense_Mutation_p.R1488*|ANK1_ENST00000265709.8_Nonsense_Mutation_p.R1529*|ANK1_ENST00000396945.1_Nonsense_Mutation_p.R1488*			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1488	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CGGCTCTGTCGGCCGGAACCC	0.592000													14	40					0	0	1	0	0
SLC39A3	29985	broad.mit.edu	37	19	2733206	2733206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2733206G>A	ENST00000269740.4	-	3	817	c.488C>T	c.(487-489)tCg>tTg	p.S163L	AC006538.4_ENST00000586572.1_Intron|SLC39A3_ENST00000545664.1_Missense_Mutation_p.S163L	NM_144564.4	NP_653165.2	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter), member 3	163						integral to membrane|plasma membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGCGCGCGAGAGGCCCTG	0.731000													15	35					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55863771	55863771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55863771G>A	ENST00000388975.3	-	10	1250	c.1134C>T	c.(1132-1134)ttC>ttT	p.F378F		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	378					cell cycle|cell division	septin complex	GTP binding|protein binding	p.F378F(1)|p.F167F(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TAAGATGCTCGAACTTGTCCT	0.378000													15	33					0	0	1	0	0
RSBN1L	222194	broad.mit.edu	37	7	77402549	77402549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:77402549C>T	ENST00000334955.7	+	6	1738	c.1711C>T	c.(1711-1713)Cat>Tat	p.H571Y	RSBN1L_ENST00000445288.1_Missense_Mutation_p.H301Y	NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	571						nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GACAAGAGCTCATGCAGATCA	0.423000													28	66					0	0	1	0	0
MIR498	574460	broad.mit.edu	37	19	54177468	54177468	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54177468G>A	ENST00000385134.1	+	0	18					NR_030182.1																						CTTGGGAAGTGAAGCTCAGGC	0.478000													39	99					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36109295	36109295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36109295C>T	ENST00000303965.4	-	27	4666	c.4177G>A	c.(4177-4179)Gaa>Aaa	p.E1393K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1393	Ras-associating.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGTACATTTTCCTTGTAGTGA	0.343000													43	99					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27703021	27703021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27703021G>A	ENST00000438700.3	-	1	276	c.159C>T	c.(157-159)tcC>tcT	p.S53S		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	53					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						AGGGTTCGGGGGATTTCGGGG	0.697000													36	84					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56587632	56587632	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56587632C>T	ENST00000336078.4	+	4	2889	c.2113C>T	c.(2113-2115)Ctt>Ttt	p.L705F	ZNF532_ENST00000589288.1_Missense_Mutation_p.L705F|ZNF532_ENST00000591808.1_Missense_Mutation_p.L705F|ZNF532_ENST00000591083.1_Missense_Mutation_p.L705F|ZNF532_ENST00000591230.1_Missense_Mutation_p.L705F	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						AACTTCCACTCTTCAGAGCCC	0.483000													6	92					0	0	1	0	0
ZNF556	80032	broad.mit.edu	37	19	2877393	2877393	+	Missense_Mutation	SNP	G	G	A	rs35499960	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2877393G>A	ENST00000586426.1	+	4	521	c.434G>A	c.(433-435)cGg>cAg	p.R145Q	ZNF556_ENST00000307635.2_Missense_Mutation_p.R146Q			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTGTAAGACGGTACGAATGC	0.393000													37	110					0	0	1	0	0
IGHV3-66	28412	broad.mit.edu	37	14	107131135	107131135	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107131135C>T	ENST00000390632.2	-	0	324																											ATCGGCCCTTCACGGAGTCTG	0.522000													15	165					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136320418	136320418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136320418C>T	ENST00000371929.3	+	25	3705	c.3261C>T	c.(3259-3261)tcC>tcT	p.S1087S	ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000356589.2_Silent_p.S1056S|ADAMTS13_ENST00000485925.1_3'UTR|ADAMTS13_ENST00000355699.2_Silent_p.S1087S	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	1087	TSP type-1 8.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GCTCTGTTTCCTGTGGGGATG	0.617000													20	167					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142561799	142561799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142561799C>T	ENST00000392957.2	+	7	1028	c.241C>T	c.(241-243)Cct>Tct	p.P81S	EPHB6_ENST00000442129.1_Missense_Mutation_p.P81S|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	81						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GGCAGGGGCCCCTCCAGGCAC	0.632000													77	202					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389390	4389390	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4389390G>A	ENST00000408920.2	-	1	226	c.136C>T	c.(136-138)Ctg>Ttg	p.L46L		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGATGAGCAGGCTGTTCCCA	0.527000													13	27					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104493142	104493142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104493142G>A	ENST00000409874.4	+	28	3196	c.3148G>A	c.(3148-3150)Gtc>Atc	p.V1050I	TDRD9_ENST00000339063.5_Missense_Mutation_p.V1050I	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	1050					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				CCTTGTGAAGGTCTTCTCTGT	0.572000													23	58					0	0	1	0	0
CNDP1	84735	broad.mit.edu	37	18	72238431	72238431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:72238431G>A	ENST00000582365.1	+	6	704	c.638G>A	c.(637-639)aGa>aAa	p.R213K	CNDP1_ENST00000358821.3_Missense_Mutation_p.R256K			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)	256					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GTGAAATGCAGAGACCAGGAT	0.413000													28	90					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8755350	8755350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:8755350G>A	ENST00000378641.3	+	27	3570	c.3095G>A	c.(3094-3096)cGa>cAa	p.R1032Q	PLCB1_ENST00000338037.6_Missense_Mutation_p.R1032Q|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Missense_Mutation_p.R1032Q	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1032					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TACCAGAAGCGAGAACATATT	0.373000													25	74					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74429817	74429817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74429817G>A	ENST00000376332.3	-	2	639	c.143C>T	c.(142-144)cCc>cTc	p.P48L	CHRDL2_ENST00000263671.5_Missense_Mutation_p.P48L|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	48	VWFC 1.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					CTCCAAGTAGGGGTGCCAGCT	0.587000													7	25					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2893767	2893767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:2893767G>A	ENST00000380698.4	-	5	534	c.445C>T	c.(445-447)Ccg>Tcg	p.P149S		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	149					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GAGCTACCCGGCAACAACTCT	0.398000													41	102					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453654	84453654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:84453654G>A	ENST00000377084.2	-	1	2874	c.1989C>T	c.(1987-1989)tcC>tcT	p.S663S		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	663						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTGTCTGTAGGGAATTAATCT	0.557000													5	34					0	0	1	0	0
MISP	126353	broad.mit.edu	37	19	757826	757826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:757826G>A	ENST00000215582.6	+	2	983	c.880G>A	c.(880-882)Gag>Aag	p.E294K		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GACGCCCATCGAGCGGGAGAT	0.667000													9	66					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21396000	21396000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:21396000G>A	ENST00000400602.2	-	9	1051	c.1016C>T	c.(1015-1017)tCt>tTt	p.S339F	XPO4_ENST00000255305.6_Missense_Mutation_p.S339F	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	339					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		CACAGCTTCAGAATCTTCTAT	0.338000													17	45					0	0	1	0	0
GYPA	2993	broad.mit.edu	37	4	145039905	145039905	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:145039905C>T	ENST00000360771.4	-	4	348	c.232_splice	c.e4-1	p.G78_splice	GYPB_ENST00000283126.7_Intron|GYPA_ENST00000324022.10_Splice_Site_p.G45_splice|RP11-673E1.4_ENST00000506982.1_RNA|GYPA_ENST00000504786.1_Splice_Site_p.G46_splice|GYPA_ENST00000512789.1_Splice_Site_p.G13_splice|GYPA_ENST00000535709.1_Splice_Site_p.G52_splice|GYPA_ENST00000512064.1_Intron|GYPA_ENST00000503627.1_Intron	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	78			G -> R (in ERIK antigen; dbSNP:rs1800582).		interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					TACCCTTTCTCCTATAAAGCA	0.318000													26	74					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55277720	55277720	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55277720G>A	ENST00000358193.3	+	6	674	c.618_splice	c.e6-1	p.G207_splice	C1orf177_ENST00000371273.3_Splice_Site_p.G207_splice	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	207										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						GTGCTCTAGGGGAGTGGTCTG	0.627000													25	119					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94486955	94486955	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:94486955G>A	ENST00000375708.3	-	9	2019	c.1821C>T	c.(1819-1821)tcC>tcT	p.S607S	ROR2_ENST00000375715.1_Silent_p.S467S|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	607	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CGTGGTGGCTGGATAGGTACT	0.607000													23	51					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140615524	140615524	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140615524C>T	ENST00000526308.1	+	0	1587					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						ACAACAGCCCCGCCCTGCACA	0.637000													87	275					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123516367	123516367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123516367C>T	ENST00000392770.2	-	2	949	c.147G>A	c.(145-147)atG>atA	p.M49I	SCN3B_ENST00000530277.1_Missense_Mutation_p.M49I|SCN3B_ENST00000299333.3_Missense_Mutation_p.M49I	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	49	Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		CCTCTCTCTTCATGCAGGAGA	0.577000													27	133					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114278641	114278641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114278641C>T	ENST00000357077.4	+	38	8920	c.8867C>T	c.(8866-8868)tCt>tTt	p.S2956F	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.S2923F|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2923					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGTTTTCACTCTTCTGAAGTG	0.393000													56	245					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56373451	56373451	+	Silent	SNP	G	G	A	rs148970920		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56373451G>A	ENST00000301295.6	+	5	2534	c.2112G>A	c.(2110-2112)acG>acA	p.T704T	NLRP4_ENST00000587891.1_Silent_p.T629T|NLRP4_ENST00000346986.5_Silent_p.T704T	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	704							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCACCCTCACGAAACTCTCTC	0.463000													45	94					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48331680	48331680	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:48331680G>A	ENST00000428869.2	-	6	531	c.273C>T	c.(271-273)ctC>ctT	p.L91L	MRO_ENST00000436348.2_Silent_p.L105L|MRO_ENST00000587291.1_5'UTR|MRO_ENST00000256425.2_Silent_p.L91L|MRO_ENST00000398439.3_Silent_p.L91L|MRO_ENST00000588444.1_Silent_p.L91L|MRO_ENST00000431965.2_Silent_p.L105L			Q9BYG7	MSTRO_HUMAN	maestro	91						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		CCAGCAGGTCGAGGACAATTT	0.463000													15	91					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179622401	179622401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179622401C>T	ENST00000589042.1	-	45	10770	c.10546G>A	c.(10546-10548)Gag>Aag	p.E3516K	TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Missense_Mutation_p.E3470K|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3197	Ig-like 21.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGACTCCTCAAAATGGAAA	0.453000													35	96					0	0	1	0	0
ZNF623	9831	broad.mit.edu	37	8	144732203	144732203	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144732203C>T	ENST00000501748.2	+	1	250	c.161C>T	c.(160-162)cCc>cTc	p.P54L	ZNF623_ENST00000458270.2_Missense_Mutation_p.P14L|ZNF623_ENST00000526926.1_Missense_Mutation_p.P14L	NM_014789.3	NP_055604.3	O75123	ZN623_HUMAN	zinc finger protein 623	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GTCCACGAGCCCAGATTAGGG	0.567000													20	56					0	0	1	0	0
DYDC2	84332	broad.mit.edu	37	10	82122265	82122265	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:82122265G>A	ENST00000372199.1	+	4	664	c.66G>A	c.(64-66)gcG>gcA	p.A22A	DYDC2_ENST00000256039.2_Silent_p.A22A|DYDC2_ENST00000372198.1_Silent_p.A36A|DYDC2_ENST00000444807.2_Silent_p.A22A|DYDC2_ENST00000372197.1_Silent_p.A22A			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	22							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			CAGAGGTGGCGAAGGTTCGGC	0.488000													24	52					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540736	94540736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94540736G>A	ENST00000289495.5	+	1	1527	c.1311G>A	c.(1309-1311)atG>atA	p.M437I	PPP1R9A_ENST00000424654.1_Missense_Mutation_p.M437I|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.M437I|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.M437I|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.M437I|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.M437I	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	437	Interacts with protein phosphatase 1 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGCCTGATATGGAGTACTCGG	0.418000										HNSCC(28;0.073)			16	39					0	0	1	0	0
LCMT1	51451	broad.mit.edu	37	16	25151534	25151534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:25151534C>T	ENST00000399069.3	+	4	525	c.370C>T	c.(370-372)Cca>Tca	p.P124S	LCMT1_ENST00000380966.4_Missense_Mutation_p.P124S	NM_016309.2	NP_057393.2	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1	124							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity								GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	GGTTGACTTTCCAATGATTGT	0.403000													5	9					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104642395	104642395	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104642395C>T	ENST00000315264.7	+	11	3231	c.2853C>T	c.(2851-2853)gcC>gcT	p.A951A	KIF26A_ENST00000423312.2_Silent_p.A1090A			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1090					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCTCTCAGGCCCCTGAGGGGG	0.672000													7	12					0	0	1	0	0
C4B	721	broad.mit.edu	37	6	31997551	31997551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31997551C>T	ENST00000435363.2	+	29	3969	c.3885C>T	c.(3883-3885)ttC>ttT	p.F1295F	C4B_ENST00000425700.2_Silent_p.F1295F	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1295					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										AGGGCAGCTTCCAAGGGGGAT	0.642000													14	66					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15977991	15977991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:15977991G>A	ENST00000262101.5	-	9	1279	c.1158C>T	c.(1156-1158)gtC>gtT	p.V386V	MSR1_ENST00000445506.2_Silent_p.V404V|MSR1_ENST00000355282.2_Intron|MSR1_ENST00000350896.3_Intron			P21757	MSRE_HUMAN	macrophage scavenger receptor 1	386	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TCCTACAGACGACCTGTCCAA	0.542000													50	115					0	0	1	0	0
SSX5	6758	broad.mit.edu	37	X	48047090	48047090	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48047090C>T	ENST00000311798.1	-	8	719	c.667G>A	c.(667-669)Gac>Aac	p.D223N	SSX5_ENST00000376923.1_Missense_Mutation_p.D182N|SSX5_ENST00000347757.1_Missense_Mutation_p.D182N	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						TCCTGAGGGTCGCTGATCTCT	0.483000													114	114					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123332988	123332988	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123332988C>T	ENST00000360772.3	-	34	5934	c.5556G>A	c.(5554-5556)gaG>gaA	p.E1852E	MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000346322.5_Silent_p.E1834E|MYLK_ENST00000418370.2_Silent_p.E143E|MYLK_ENST00000583087.1_Silent_p.E143E|MYLK_ENST00000578202.1_Silent_p.E142E|MYLK_ENST00000354792.5_Silent_p.E703E|MYLK_ENST00000359169.1_Silent_p.E1852E|MYLK-AS1_ENST00000463408.1_RNA|MYLK-AS1_ENST00000470449.1_RNA|MYLK_ENST00000475616.1_Silent_p.E1903E|MYLK_ENST00000360304.3_Silent_p.E1903E			Q15746	MYLK_HUMAN	myosin light chain kinase	1903	Ig-like C2-type 9.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CTTCACCTTCCTCCATCGTTT	0.458000													32	292					0	0	1	0	0
OGFRL1	79627	broad.mit.edu	37	6	72006513	72006513	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:72006513C>T	ENST00000370435.4	+	6	819	c.685C>T	c.(685-687)Ctg>Ttg	p.L229L	RP11-154D6.1_ENST00000591156.1_RNA|RP11-154D6.1_ENST00000586030.1_RNA|RP11-154D6.1_ENST00000423255.1_RNA|RP11-154D6.1_ENST00000588612.1_RNA|RP11-154D6.1_ENST00000587253.1_RNA|RP3-331H24.5_ENST00000602823.1_lincRNA|RP11-154D6.1_ENST00000432050.1_RNA|RP11-154D6.1_ENST00000586232.1_RNA|RP11-154D6.1_ENST00000412751.1_RNA	NM_024576.3	NP_078852.3	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	229						membrane	receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|upper_aerodigestive_tract(1)	13						ATTTCAGCATCTGAATGAGTA	0.408000													6	64					0	0	1	0	0
WNT3	7473	broad.mit.edu	37	17	44851147	44851147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:44851147G>A	ENST00000225512.5	-	2	371	c.209C>T	c.(208-210)gCc>gTc	p.A70V		NM_030753.4	NP_110380.1	P56703	WNT3_HUMAN	wingless-type MMTV integration site family, member 3	70					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			endometrium(2)|large_intestine(6)|lung(4)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(9;0.0257)			CACGCCCTCGGCCACGCTGGG	0.647000													28	36					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35043180	35043180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35043180G>A	ENST00000312292.5	+	2	601	c.554G>A	c.(553-555)gGg>gAg	p.G185E	C9orf131_ENST00000421362.2_Missense_Mutation_p.G137E|C9orf131_ENST00000354479.5_Missense_Mutation_p.G112E	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	185										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			ATAGCATCAGGGAACCGCCAG	0.567000													39	99					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107097124	107097124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:107097124G>A	ENST00000261058.1	+	1	937	c.690G>A	c.(688-690)agG>agA	p.R230R		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	230										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						ATGCATCAAGGAGCTTTGAAA	0.368000													54	122					0	0	1	0	0
GTF2F2	2963	broad.mit.edu	37	13	45725907	45725907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:45725907C>T	ENST00000340473.6	+	4	386	c.245C>T	c.(244-246)cCa>cTa	p.P82L		NM_004128.2	NP_004119.1	P13984	T2FB_HUMAN	general transcription factor IIF, polypeptide 2, 30kDa	82					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	microtubule cytoskeleton|transcription factor TFIIF complex	ATP binding|ATP-dependent helicase activity|DNA binding|protein binding			breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|prostate(1)|upper_aerodigestive_tract(1)	10		Lung NSC(96;0.00115)|Prostate(109;0.00578)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000647)		AGAGAACATCCATTTGTCTTG	0.368000													60	161					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400585	89400585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89400585C>T	ENST00000439576.2	+	12	5143	c.4769C>T	c.(4768-4770)cCt>cTt	p.P1590L	ACAN_ENST00000352105.7_Missense_Mutation_p.P1590L|ACAN_ENST00000559004.1_Missense_Mutation_p.P1590L|ACAN_ENST00000561243.1_Missense_Mutation_p.P1590L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1590					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTGGGTTGCCTTCTGGAAAA	0.532000													15	154					0	0	1	0	0
CEACAM21	90273	broad.mit.edu	37	19	42090779	42090779	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42090779C>T	ENST00000407170.2	+	5	1209	c.396C>T	c.(394-396)ctC>ctT	p.L132L	CEACAM21_ENST00000401445.2_Silent_p.L260L|CEACAM21_ENST00000187608.9_Silent_p.L259L|CEACAM21_ENST00000482870.2_3'UTR			Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	260						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						GTTTCCTGCTCCTCCGAAAAA	0.537000													6	12					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54373514	54373514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:54373514C>T	ENST00000306888.2	-	3	708	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	LNX1-AS1_ENST00000514364.1_RNA|LNX1_ENST00000263925.7_Missense_Mutation_p.E249K|LNX1-AS1_ENST00000511989.1_RNA|FIP1L1_ENST00000507166.1_Intron|LNX1-AS1_ENST00000510785.1_RNA	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	249						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TCAGAATTTTCCCTGCCCTGG	0.488000													30	81					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475061	16475061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16475061G>A	ENST00000358432.5	-	3	789	c.635C>T	c.(634-636)cCt>cTt	p.P212L	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	212	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GATGGTCTCAGGGAAGTGGGC	0.652000													19	48					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3753941	3753941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3753941G>A	ENST00000378230.3	-	9	1358	c.1034C>T	c.(1033-1035)cCt>cTt	p.P345L		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	345						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						ATATGATGAAGGCTTTTCCTG	0.448000													18	42					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922226	37922226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37922226C>T	ENST00000346872.3	-	8	1408	c.1347G>A	c.(1345-1347)atG>atA	p.M449I	IKZF3_ENST00000439167.2_Missense_Mutation_p.M376I|IKZF3_ENST00000350532.3_Missense_Mutation_p.M410I|IKZF3_ENST00000583368.1_Missense_Mutation_p.M202I|IKZF3_ENST00000377958.2_Missense_Mutation_p.M362I|IKZF3_ENST00000467757.1_Missense_Mutation_p.M393I|IKZF3_ENST00000351680.3_Missense_Mutation_p.M410I|IKZF3_ENST00000377952.2_Missense_Mutation_p.M228I|IKZF3_ENST00000346243.3_Missense_Mutation_p.M371I|IKZF3_ENST00000377944.3_Missense_Mutation_p.M306I|IKZF3_ENST00000535189.1_Missense_Mutation_p.M415I|IKZF3_ENST00000394189.2_Missense_Mutation_p.M267I|IKZF3_ENST00000439016.2_Missense_Mutation_p.M354I|IKZF3_ENST00000377945.3_Missense_Mutation_p.M315I	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	449					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATACACATCCATCACCTCCC	0.557000													57	66					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873265	36873265	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36873265G>A	ENST00000301807.6	-	21	7924	c.6027C>T	c.(6025-6027)tgC>tgT	p.C2009C	TRANK1_ENST00000429976.2_Silent_p.C2559C|TRANK1_ENST00000428977.2_Silent_p.C2009C	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2559					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CCTGGCCAGGGCAGTCCATGC	0.572000													27	72					0	0	1	0	0
SLC35D2	11046	broad.mit.edu	37	9	99126776	99126776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:99126776G>A	ENST00000253270.7	-	3	311	c.249C>T	c.(247-249)ttC>ttT	p.F83F	SLC35D2_ENST00000375259.4_Silent_p.F83F|SLC35D2_ENST00000375257.1_Silent_p.F83F|SLC35D2_ENST00000482643.1_5'UTR	NM_007001.2	NP_008932.2	Q76EJ3	S35D2_HUMAN	solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2	83						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity			endometrium(3)|large_intestine(3)|lung(4)|skin(2)	12		Acute lymphoblastic leukemia(62;0.0167)				CAAAATCAGGGAAGTGAATGA	0.338000													46	127					0	0	1	0	0
VPS35	55737	broad.mit.edu	37	16	46716030	46716030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:46716030G>A	ENST00000299138.7	-	3	218	c.160C>T	c.(160-162)Cgg>Tgg	p.R54W		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	54					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				ATAGAAGTCCGGAGTTCACCA	0.333000													10	41					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126784913	126784913	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:126784913C>T	ENST00000274473.6	+	23	3246	c.2980_splice	c.e23+1	p.L993_splice	MEGF10_ENST00000510828.1_3'UTR|MEGF10_ENST00000503335.2_Splice_Site_p.L993_splice	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	993	Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TCAACGAGCTCGGTGAGTTCT	0.532000													34	68					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41594887	41594887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41594887C>T	ENST00000330436.3	+	2	234	c.234C>T	c.(232-234)gtC>gtT	p.V78V		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	78					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	CCCGGCGGGTCGTGGTGCTGT	0.637000													26	82					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026783	79026783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79026783C>T	ENST00000446378.2	+	2	2226	c.2195C>T	c.(2194-2196)cCa>cTa	p.P732L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	732						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TACATGATTCCATCAGAAGAG	0.448000													24	69					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33411949	33411949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33411949G>A	ENST00000404816.2	+	6	1581	c.1228G>A	c.(1228-1230)Ggt>Agt	p.G410S	LTBP1_ENST00000404525.1_Missense_Mutation_p.G84S|LTBP1_ENST00000402934.1_Missense_Mutation_p.G84S|LTBP1_ENST00000390003.4_Missense_Mutation_p.G84S|LTBP1_ENST00000418533.2_Missense_Mutation_p.G84S|LTBP1_ENST00000407925.1_Missense_Mutation_p.G84S|LTBP1_ENST00000354476.3_Missense_Mutation_p.G410S			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	410	EGF-like 2.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity	p.G410C(1)		breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ATGTATGAATGGTGGCCAGTG	0.433000													20	45					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35504607	35504607	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35504607G>A	ENST00000217320.3	+	1	74	c.30G>A	c.(28-30)cgG>cgA	p.R10R	TLDC2_ENST00000602922.1_Silent_p.R10R	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		GTTACACTCGGCTGGTAAGGG	0.637000													13	132					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383132	22383132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22383132C>T	ENST00000328795.4	+	1	751	c.660C>T	c.(658-660)gtC>gtT	p.V220V	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCTATGCAGTCATCCTCTGCC	0.502000													27	81					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631980	32631980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32631980G>A	ENST00000242310.4	-	1	3687	c.3598C>T	c.(3598-3600)Cgc>Tgc	p.R1200C		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1200					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GTCTCACAGCGAACATACTCT	0.428000													15	142					0	0	1	0	0
ASTE1	28990	broad.mit.edu	37	3	130743962	130743962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130743962G>A	ENST00000264992.3	-	3	630	c.189C>T	c.(187-189)ttC>ttT	p.F63F	ASTE1_ENST00000514044.1_Silent_p.F63F	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	63					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						GTGATTCAAAGAATTTTTGTA	0.363000													12	98					0	0	1	0	0
RBP5	83758	broad.mit.edu	37	12	7280989	7280989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7280989G>A	ENST00000266560.3	-	2	265	c.99C>T	c.(97-99)atC>atT	p.I33I	RBP5_ENST00000542370.1_Silent_p.I33I	NM_031491.2	NP_113679.1	P82980	RET5_HUMAN	retinol binding protein 5, cellular	33						cytoplasm	retinal binding|retinol binding|transporter activity			autonomic_ganglia(1)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)	10					Vitamin A(DB00162)	GCAGCAGCGCGATCTTCCGCA	0.607000													14	54					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23912862	23912862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:23912862G>A	ENST00000382298.3	-	10	5741	c.5153C>T	c.(5152-5154)tCc>tTc	p.S1718F	SACS_ENST00000402364.1_Missense_Mutation_p.S968F|SACS_ENST00000382292.3_Missense_Mutation_p.S1718F	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1718					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GGAAGAGCAGGATTTTTTTTT	0.358000													40	29					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93090139	93090139	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:93090139C>T	ENST00000359558.2	-	10	1043	c.744G>A	c.(742-744)agG>agA	p.R248R	CALCR_ENST00000394441.1_Silent_p.R214R|CALCR_ENST00000421592.1_Silent_p.R230R|CALCR_ENST00000360249.4_Silent_p.R230R|CALCR_ENST00000426151.1_Silent_p.R214R	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	230					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TTACCGGGTCCCTTCGCACGA	0.383000													23	115					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9523354	9523354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9523354G>A	ENST00000378429.3	-	10	2429	c.1883C>T	c.(1882-1884)tCc>tTc	p.S628F	PAK7_ENST00000378423.1_Missense_Mutation_p.S628F|PAK7_ENST00000353224.5_Missense_Mutation_p.S628F	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	628	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GATCCCGAGGGACCAGATGTC	0.517000													18	74					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46801068	46801068	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46801068G>A	ENST00000230588.4	+	11	1411	c.1402G>A	c.(1402-1404)Ggg>Agg	p.G468R		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	468	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			ATATGGTTTTGGGGTAACTTT	0.493000													31	77					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56443363	56443363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56443363C>T	ENST00000588751.1	-	1	339	c.315G>A	c.(313-315)atG>atA	p.M105I	NLRP13_ENST00000342929.3_Missense_Mutation_p.M105I			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	105	DAPIN.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TCTCACCTTTCATCTCGGCTC	0.532000													14	44					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88420335	88420335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:88420335C>T	ENST00000298699.2	-	3	243	c.63G>A	c.(61-63)gtG>gtA	p.V21V	C12orf50_ENST00000550553.1_Silent_p.V21V	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	21										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						AGCTGATCTTCACACAACCAA	0.368000													7	78					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184610	6184610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6184610G>A	ENST00000262450.3	-	30	4605	c.4506C>T	c.(4504-4506)acC>acT	p.T1502T	CHD5_ENST00000378021.1_Silent_p.T359T	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1502					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCCCGATGCGGGTCAGCACGT	0.647000													11	27					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37732434	37732434	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:37732434G>A	ENST00000330843.4	-	3	1233	c.1221C>T	c.(1219-1221)gaC>gaT	p.D407D	RAB11FIP1_ENST00000287263.4_Silent_p.D407D|RAB11FIP1_ENST00000524118.1_Silent_p.D259D|RAB11FIP1_ENST00000522727.1_Silent_p.D259D	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	407					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TTTCCCTGAGGTCCCCACTGA	0.562000													25	74					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535765	69535765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69535765G>A	ENST00000338206.5	-	1	581	c.572C>T	c.(571-573)cCt>cTt	p.P191L		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	191					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										ATAGGAAGGAGGGAACAGAAA	0.368000													52	216					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57171830	57171830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57171830G>A	ENST00000371244.4	+	8	1425	c.1359G>A	c.(1357-1359)atG>atA	p.M453I		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	453					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						ACGTGAAAATGAGCTTACAAC	0.343000													28	63					0	0	1	0	0
SLC2A12	154091	broad.mit.edu	37	6	134350251	134350251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:134350251C>T	ENST00000275230.5	-	2	867	c.712G>A	c.(712-714)Gga>Aga	p.G238R		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	238						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		CTTAACCTTCCAAGAACCTTG	0.443000													33	42					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151094619	151094619	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151094619G>A	ENST00000474524.1	+	27	4018	c.3980G>A	c.(3979-3981)tGg>tAg	p.W1327*	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Nonsense_Mutation_p.W1187*	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1327					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGGCAATCCTGGTTAGAACTC	0.343000													12	73					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196722403	196722403	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196722403G>T	ENST00000312428.6	-	44	8212	c.8112C>A	c.(8110-8112)gtC>gtA	p.V2704V		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2704	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TAACAAGCTTGACACCAGCAG	0.368000													12	53					1.49906e-05	1.50184e-05	1	1	0
OR13A1	79290	broad.mit.edu	37	10	45799190	45799190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45799190C>T	ENST00000553795.1	-	4	989	c.681G>A	c.(679-681)gtG>gtA	p.V227V	OR13A1_ENST00000536058.1_Silent_p.V227V|OR13A1_ENST00000374401.2_Silent_p.V227V	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						TCAGGAAGTTCACTATGCCGT	0.552000													20	78					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122001066	122001066	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122001066A>T	ENST00000498619.1	+	6	2183	c.1745A>T	c.(1744-1746)gAg>gTg	p.E582V	CASR_ENST00000296154.5_Missense_Mutation_p.E572V|CASR_ENST00000490131.1_Missense_Mutation_p.E572V	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	572			C -> F (in FHH).|C -> Y (in NSHPT).		anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCTGATGGGGAGTATAGTGAT	0.597000													29	66					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579837	55579837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55579837G>A	ENST00000333973.2	+	1	984	c.895G>A	c.(895-897)Gaa>Aaa	p.E299K		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				AGATGTGAAAGAAGCTCTCAG	0.463000													22	51					0	0	1	0	0
CNOT6L	246175	broad.mit.edu	37	4	78641627	78641627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:78641627G>A	ENST00000504123.1	-	12	1756	c.1626C>T	c.(1624-1626)ctC>ctT	p.L542L	CNOT6L_ENST00000264903.4_Silent_p.L542L			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	542					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						CAAGAGGCAGGAGTGGAGGGT	0.507000													28	120					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188634	140188634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140188634C>T	ENST00000530339.1	+	1	1862	c.1862C>T	c.(1861-1863)cCg>cTg	p.P621L	PCDHA4_ENST00000512229.2_Missense_Mutation_p.P621L|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.P621L|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1												p.P621L(2)		breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCATCCCGTTCCGCGTG	0.672000													25	84					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165175145	165175145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165175145C>T	ENST00000342310.3	-	8	1326	c.944G>A	c.(943-945)gGt>gAt	p.G315D	LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Missense_Mutation_p.G315D|LMX1A_ENST00000367893.4_Missense_Mutation_p.G315D	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	315						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					TGGGGTGAGACCCTGTCGGAA	0.577000													28	57					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180056393	180056393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180056393G>A	ENST00000261937.6	-	7	929	c.851C>T	c.(850-852)tCc>tTc	p.S284F	FLT4_ENST00000393347.3_Missense_Mutation_p.S284F|FLT4_ENST00000502649.1_Missense_Mutation_p.S284F|FLT4_ENST00000424276.2_5'UTR	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	284	Ig-like C2-type 3.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GGTCTGCTGGGAGCGTCGCTC	0.657000													20	35					0	0	1	0	0
LRRC48	83450	broad.mit.edu	37	17	17891358	17891358	+	Silent	SNP	C	C	T	rs145108400	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:17891358C>T	ENST00000313838.8	+	6	769	c.390C>T	c.(388-390)ctC>ctT	p.L130L	LRRC48_ENST00000399187.1_Silent_p.L130L|LRRC48_ENST00000584166.1_Silent_p.L130L|LRRC48_ENST00000411504.2_Silent_p.L130L|LRRC48_ENST00000399182.1_Silent_p.L130L	NM_001130090.1	NP_001123562.1	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48	130						cytoplasm				breast(1)|large_intestine(2)|lung(2)|pancreas(1)|urinary_tract(1)	7	all_neural(463;0.228)					TGGACGCCCTCGTCAAGCTGC	0.587000													14	29					0	0	1	0	0
WAS	7454	broad.mit.edu	37	X	48542353	48542353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48542353G>A	ENST00000376701.4	+	1	186	c.111G>A	c.(109-111)gaG>gaA	p.E37E	WAS_ENST00000483750.1_3'UTR	NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	37					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				GACTCTTTGAGATGCTTGGAC	0.622000			"""Mis, N, F, S"""			lymphoma							38	26					0	0	1	0	0
TMEM125	128218	broad.mit.edu	37	1	43738463	43738463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43738463G>A	ENST00000432792.2	+	4	640	c.70G>A	c.(70-72)Gag>Aag	p.E24K	TMEM125_ENST00000439858.1_Missense_Mutation_p.E24K			Q96AQ2	TM125_HUMAN	transmembrane protein 125	24						integral to membrane				breast(1)|large_intestine(1)|lung(1)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGAGCAGGTGGAGCTGTGGTG	0.721000													8	8					0	0	1	0	0
CETN1	1068	broad.mit.edu	37	18	580874	580874	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:580874G>A	ENST00000327228.3	+	1	508	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	156	EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						TGGGGACGGCGAAGTGAACGA	0.537000													40	22					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141081603	141081603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141081603C>T	ENST00000389484.3	-	81	13344	c.12373G>A	c.(12373-12375)Gaa>Aaa	p.E4125K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4125					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATATAATCTTCAAAGATATCG	0.289000										TSP Lung(27;0.18)			38	111					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30366743	30366743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30366743G>A	ENST00000340513.4	+	10	1538	c.1010G>A	c.(1009-1011)cGa>cAa	p.R337Q	TPX2_ENST00000300403.6_Missense_Mutation_p.R337Q			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	337					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			TTCCATAAACGAACCCCTAAC	0.413000													44	94					0	0	1	0	0
LUZP2	338645	broad.mit.edu	37	11	24759824	24759824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:24759824G>A	ENST00000533227.1	+	4	338	c.51G>A	c.(49-51)gaG>gaA	p.E17E	LUZP2_ENST00000336930.6_Silent_p.E103E|LUZP2_ENST00000531187.1_3'UTR	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	103						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						AGACATCAGAGAAAGCAGAAA	0.373000													15	37					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25280503	25280503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25280503G>A	ENST00000218548.6	+	15	2422	c.2089G>A	c.(2089-2091)Gaa>Aaa	p.E697K	ATP12A_ENST00000381946.3_Missense_Mutation_p.E691K	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	691					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CATGAGCTCAGAACAGCTGGA	0.562000													22	56					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	69281668	69281668	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:69281668G>A	ENST00000433211.1	-	5	685	c.511C>T	c.(511-513)Cag>Tag	p.Q171*	CTNNA3_ENST00000545309.1_Nonsense_Mutation_p.Q171*|CTNNA3_ENST00000373744.4_Nonsense_Mutation_p.Q171*	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	171					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TAGGTTTTCTGGAGGTCAGAT	0.408000													36	88					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100087130	100087130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100087130G>A	ENST00000423930.1	+	4	1945	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	NYAP1_ENST00000454988.1_Missense_Mutation_p.D539N|NYAP1_ENST00000300179.2_Missense_Mutation_p.D596N			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	596																	GCAAGGGACCGATGGGGGTGC	0.637000													31	60					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38957887	38957887	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38957887C>T	ENST00000359357.3	+	86	12756	c.12502C>T	c.(12502-12504)Cag>Tag	p.Q4168*	DNAH8_ENST00000441566.1_Nonsense_Mutation_p.Q4132*					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGAATACATCCAGTCACTGCC	0.408000													63	182					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130292831	130292831	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130292831C>T	ENST00000358511.6	+	7	3040	c.3009C>T	c.(3007-3009)ttC>ttT	p.F1003F	COL6A6_ENST00000453409.2_Silent_p.F1003F	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1003	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ATCTTGTTTTCCTTATGGATG	0.363000													11	33					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542468	55542468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55542468G>A	ENST00000220676.1	+	4	6174	c.6026G>A	c.(6025-6027)aGa>aAa	p.R2009K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	2009					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAACAAAAAAGAATTAACTTC	0.294000													43	81					0	0	1	0	0
OR52E2	119678	broad.mit.edu	37	11	5080338	5080338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5080338G>A	ENST00000321522.2	-	1	519	c.520C>T	c.(520-522)Cat>Tat	p.H174Y		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGAATTACATGATTCCCACAG	0.403000													12	32					0	0	1	0	0
AK2	204	broad.mit.edu	37	1	33478956	33478956	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33478956G>A	ENST00000373449.2	-	6	587	c.546C>T	c.(544-546)gcC>gcT	p.A182A	RP1-117O3.2_ENST00000427524.1_RNA|AK2_ENST00000548033.1_Silent_p.A140A|AK2_ENST00000354858.6_Silent_p.A182A|AK2_ENST00000480134.1_3'UTR|AK2_ENST00000467905.1_Silent_p.A182A	NM_001199199.1|NM_013411.4	NP_001186128.1|NP_037543.1	P54819	KAD2_HUMAN	adenylate kinase 2	182					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				GGATTTTCAAGGCCTTTTCAT	0.512000													24	36					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148927953	148927953	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:148927953C>T	ENST00000264613.6	-	3	870		c.e3+1			NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)						cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	AGAAGATGTACCTTTTTTACA	0.403000													27	68					0	0	1	0	0
BCO2	83875	broad.mit.edu	37	11	112070448	112070448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:112070448C>T	ENST00000357685.5	+	6	898	c.763C>T	c.(763-765)Cct>Tct	p.P255S	BCO2_ENST00000526088.1_Missense_Mutation_p.P221S|BCO2_ENST00000438022.1_Missense_Mutation_p.P221S|BCO2_ENST00000531169.1_Missense_Mutation_p.P221S|BCO2_ENST00000393032.2_Missense_Mutation_p.P221S|BCO2_ENST00000361053.4_Missense_Mutation_p.P182S|BCO2_ENST00000532593.1_Missense_Mutation_p.P150S|SDHD_ENST00000532612.1_3'UTR			Q9BYV7	BCDO2_HUMAN	beta-carotene oxygenase 2	255					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)	16						TATTCGGGTTCCTCCAGAGAA	0.403000													42	104					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74824431	74824431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74824431C>T	ENST00000256362.4	+	2	1186	c.945C>T	c.(943-945)tcC>tcT	p.S315S		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	315					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CCCGCTTCTCCGCCAAGCACT	0.632000													25	75					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51054653	51054653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51054653G>A	ENST00000441560.2	+	3	620	c.139G>A	c.(139-141)Gag>Aag	p.E47K	ATL1_ENST00000358385.6_Missense_Mutation_p.E47K|ATL1_ENST00000556478.2_3'UTR|ATL1_ENST00000354525.4_Missense_Mutation_p.E47K|ATL1_ENST00000357032.3_Missense_Mutation_p.E47K	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	47					axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						CCATTCCTTTGAGTTAGATGA	0.438000													57	139					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997813	46997813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46997813C>T	ENST00000599531.1	-	1	1942	c.910G>A	c.(910-912)Gag>Aag	p.E304K	PNMAL2_ENST00000594749.1_Intron|PNMAL2_ENST00000377655.2_Intron|AC011484.1_ENST00000377652.3_5'UTR	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	304										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ACCGGCTCCTCGTCCGGGGTG	0.582000													13	112					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171071264	171071264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171071264G>A	ENST00000334231.6	+	5	479	c.479G>A	c.(478-480)cGa>cAa	p.R160Q	MYO3B_ENST00000409044.3_Missense_Mutation_p.R151Q|MYO3B_ENST00000602629.1_Intron|MYO3B_ENST00000408978.4_Missense_Mutation_p.R151Q			Q8WXR4	MYO3B_HUMAN	myosin IIIB	151	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						CACAACAACCGAATCATCCAC	0.428000													19	51					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176798513	176798513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176798513C>T	ENST00000408923.3	+	14	1609	c.1421C>T	c.(1420-1422)cCc>cTc	p.P474L	RGS14_ENST00000506944.1_3'UTR	NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	474					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCACCCATCCCCCTCCAGCG	0.597000													42	214					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32818262	32818262	+	Silent	SNP	C	C	T	rs146000974	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32818262C>T	ENST00000380250.3	+	47	7267	c.6771C>T	c.(6769-6771)gtC>gtT	p.V2257V		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACCTTTCTGTCGTTCCTGTCA	0.478000													34	114					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6867339	6867339	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6867339G>A	ENST00000299454.4	+	1	457	c.426G>A	c.(424-426)cgG>cgA	p.R142R	OR10A5_ENST00000379831.2_Silent_p.R146R			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAAGGACACGGGCCAAACTGG	0.537000													40	146					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23782435	23782435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23782435G>A	ENST00000336689.3	-	3	331	c.287C>T	c.(286-288)tCc>tTc	p.S96F	ASAP3_ENST00000437606.2_Missense_Mutation_p.S96F	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	96					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						GAAGCCTGTGGACAGCTCATG	0.572000													40	90					0	0	1	0	0
TMEM218	219854	broad.mit.edu	37	11	124967604	124967604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124967604G>A	ENST00000455225.1	-	4	897	c.246C>T	c.(244-246)gtC>gtT	p.V82V	TMEM218_ENST00000529583.1_Silent_p.V82V|TMEM218_ENST00000531262.1_5'UTR|TMEM218_ENST00000527766.1_Silent_p.V82V|TMEM218_ENST00000528724.1_Silent_p.V108V|TMEM218_ENST00000532156.1_3'UTR|TMEM218_ENST00000529609.1_3'UTR|TMEM218_ENST00000527271.1_Silent_p.V82V|TMEM218_ENST00000532407.1_Silent_p.V82V|TMEM218_ENST00000531909.1_Silent_p.V82V|TMEM218_ENST00000526175.1_Silent_p.V82V|TMEM218_ENST00000279968.4_Silent_p.V82V			A2RU14	TM218_HUMAN	transmembrane protein 218	82						integral to membrane		p.V82V(1)		breast(1)|large_intestine(2)|lung(1)|prostate(1)	5						AAGCCAGCAGGACATAGCGGC	0.448000													7	36					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59170239	59170239	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:59170239G>A	ENST00000262717.4	+	5	1113	c.715G>A	c.(715-717)Gaa>Aaa	p.E239K	CDH20_ENST00000536675.2_Missense_Mutation_p.E239K|CDH20_ENST00000538374.1_Missense_Mutation_p.E239K			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	239	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				AGAATACTACGAAGTGATTAT	0.448000											OREG0025026	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	103					0	0	1	0	0
RAD54L	8438	broad.mit.edu	37	1	46733199	46733199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46733199G>A	ENST00000371975.4	+	9	1634	c.960G>A	c.(958-960)cgG>cgA	p.R320R	RAD54L_ENST00000442598.1_Silent_p.R320R	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	320	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		CCAGCCGGCGGGTGCTCATCT	0.483000								Direct reversal of damage;Homologous recombination					35	64					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39915363	39915363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39915363C>T	ENST00000425673.1	+	17	3828	c.3503C>T	c.(3502-3504)tCg>tTg	p.S1168L	PLEKHG2_ENST00000458508.2_Missense_Mutation_p.S1138L|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.S1197L|PLEKHG2_ENST00000409797.2_Intron			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	1197	Pro-rich.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTCACACCTTCGTTGGAGCAG	0.572000													82	195					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68972915	68972915	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68972915G>A	ENST00000288368.4	+	11	1517	c.1238_splice	c.e11-1	p.E414_splice	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	414	DEP 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.E414K(2)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CTCTTGCAGCGAATTTGTGTC	0.418000													19	66					0	0	1	0	0
UBXN4	23190	broad.mit.edu	37	2	136537829	136537829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136537829C>T	ENST00000272638.9	+	12	1573	c.1262C>T	c.(1261-1263)cCa>cTa	p.P421L	UBXN4_ENST00000490163.1_3'UTR	NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	421					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						GTGCTTTATCCATTCCTTGCC	0.438000													45	121					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24454270	24454270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24454270C>T	ENST00000230036.1	-	14	1418	c.1308G>A	c.(1306-1308)gaG>gaA	p.E436E		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	436						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TCCTGTGGGCCTCCTTGTCCA	0.567000													29	85					0	0	1	0	0
C10orf113	387638	broad.mit.edu	37	10	21414830	21414830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21414830C>T	ENST00000534331.1	-	2	440	c.390G>A	c.(388-390)ggG>ggA	p.G130G	NEBL_ENST00000417816.2_Intron|C10orf113_ENST00000529198.1_3'UTR|C10orf113_ENST00000377118.4_Silent_p.G120G	NM_001010896.2	NP_001010896.2	Q5VZT2	CJ113_HUMAN	chromosome 10 open reading frame 113	130										endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|pancreas(1)	7						ATCCATGCTTCCCTTTGGTTA	0.463000													55	114					0	0	1	0	0
SLC18A1	6570	broad.mit.edu	37	8	20035989	20035989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:20035989G>A	ENST00000440926.1	-	5	974	c.504C>T	c.(502-504)atC>atT	p.I168I	SLC18A1_ENST00000276373.5_Silent_p.I168I|SLC18A1_ENST00000519026.1_Silent_p.I168I|SLC18A1_ENST00000381608.4_Silent_p.I168I|SLC18A1_ENST00000265808.7_Silent_p.I168I|SLC18A1_ENST00000437980.1_Silent_p.I168I	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1	168					neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		CAAACATGGGGATATGATATC	0.348000													6	20					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241987827	241987827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241987827G>A	ENST00000310397.8	+	9	1369	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K	SNED1_ENST00000469006.1_3'UTR|SNED1_ENST00000401884.1_Missense_Mutation_p.E457K|SNED1_ENST00000342631.6_Missense_Mutation_p.E457K|AC005237.4_ENST00000458377.1_RNA|SNED1_ENST00000405547.3_Missense_Mutation_p.E457K	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	457	EGF-like 5.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		CGAGTGCCCCGAAGGCTTCAT	0.667000													4	20					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723158	58723158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58723158G>A	ENST00000300079.5	+	7	710	c.660G>A	c.(658-660)ggG>ggA	p.G220G	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Silent_p.G189G	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	189						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	GGAAGCGAGGGAAGAATGAGA	0.498000													16	72					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18735519	18735519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18735519C>T	ENST00000513874.1	-	14	2114	c.1975G>A	c.(1975-1977)Ggg>Agg	p.G659R	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	659	Ig-like 4.							p.G659R(1)		NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TGGTCTTCCCCGCGCTCCATG	0.592000													28	76					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5759096	5759096	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5759096G>A	ENST00000381624.3	+	15	1429		c.e15-1		CATSPERD_ENST00000309164.7_Splice_Site|CATSPERD_ENST00000381614.2_Splice_Site	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta							integral to membrane											TGACCCCACAGGATATTTTCC	0.557000													32	109					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10408483	10408483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10408483C>T	ENST00000226207.5	-	21	2526	c.2432G>A	c.(2431-2433)aGa>aAa	p.R811K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	811	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTAATACCTTCTTTCCACCAT	0.418000													26	71					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109688977	109688977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:109688977G>A	ENST00000277225.5	+	3	3073	c.2784G>A	c.(2782-2784)cgG>cgA	p.R928R	ZNF462_ENST00000457913.1_Silent_p.R928R			Q96JM2	ZN462_HUMAN	zinc finger protein 462	928					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						ACCGGTGTCGGTTTTGTTCAT	0.473000													12	140					0	0	1	0	0
SPAG1	6674	broad.mit.edu	37	8	101206519	101206519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101206519G>A	ENST00000520508.1	+	10	1403	c.1119G>A	c.(1117-1119)agG>agA	p.R373R	SPAG1_ENST00000251809.3_Intron|SPAG1_ENST00000388798.2_Intron|SPAG1_ENST00000520643.1_Silent_p.R373R			Q07617	SPAG1_HUMAN	sperm associated antigen 1	0					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TTCTATTTAGGTTATGTAAAA	0.323000													5	21					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120138561	120138561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120138561G>A	ENST00000392521.2	-	44	5667	c.5612C>T	c.(5611-5613)cCt>cTt	p.P1871L	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.P1829L|RP1-127H14.3_ENST00000535109.1_Missense_Mutation_p.G50S	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1829	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		AAAGGCCAAAGGTAAGCGACT	0.547000													10	88					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174830	150174830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150174830G>A	ENST00000307271.3	+	5	2534	c.1960G>A	c.(1960-1962)Gaa>Aaa	p.E654K		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	654						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GTCCCAAGCCGAAAAACTCCT	0.463000													22	65					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154303543	154303543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154303543C>T	ENST00000368489.3	+	5	323	c.323C>T	c.(322-324)tCc>tTc	p.S108F	ATP8B2_ENST00000341822.2_Missense_Mutation_p.S94F|ATP8B2_ENST00000368487.3_Missense_Mutation_p.S75F|ATP8B2_ENST00000426445.1_3'UTR	NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	94					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAGATCTCTTCCCTGTCCTGG	0.458000													17	75					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38851680	38851680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38851680G>A	ENST00000359357.3	+	54	7768	c.7514G>A	c.(7513-7515)cGa>cAa	p.R2505Q	DNAH8_ENST00000441566.1_Missense_Mutation_p.R2469Q|DNAH8_ENST00000449981.2_Missense_Mutation_p.R2722Q					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTGGATAAGCGAATTGGAAGC	0.363000													39	72					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169484792	169484792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169484792C>T	ENST00000367796.3	-	24	6634	c.6433G>A	c.(6433-6435)Ggc>Agc	p.G2145S	F5_ENST00000495481.1_5'UTR|F5_ENST00000367797.3_Missense_Mutation_p.G2140S			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	2140	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GACTTGCAGCCCTGTGTTATA	0.398000													46	126					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109707875	109707875	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109707875C>T	ENST00000356711.2	+	27	3327	c.3201C>T	c.(3199-3201)gtC>gtT	p.V1067V	MYO16_ENST00000357550.2_Silent_p.V1067V|MYO16_ENST00000457511.2_Silent_p.V579V	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1067	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATATTGGGGTCCTGGAGATGG	0.428000													31	121					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52580396	52580396	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52580396C>T	ENST00000395489.2	-	10	1158	c.762G>A	c.(760-762)agG>agA	p.R254R	A1CF_ENST00000395495.1_Silent_p.R206R|A1CF_ENST00000373993.1_Silent_p.R261R|A1CF_ENST00000374001.1_Silent_p.R261R|A1CF_ENST00000373995.3_Silent_p.R269R|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000373997.3_Silent_p.R261R|A1CF_ENST00000282641.2_Silent_p.R261R	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	261	RRM 3.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TTTTCTTCACCCTCTCCACAG	0.393000													8	62					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94508333	94508333	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94508333G>A	ENST00000370225.3	-	22	3398	c.3312C>T	c.(3310-3312)ctC>ctT	p.L1104L		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1104	ABC transporter 1.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GATACTTCAGGAGCAGATCCC	0.572000													16	37					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106907399	106907399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106907399G>A	ENST00000369701.3	+	9	1554	c.1327G>A	c.(1327-1329)Gag>Aag	p.E443K		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	443						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGTACAGACGAGAACCAAGT	0.473000													30	79					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885581	24885581	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24885581G>A	ENST00000382554.3	+	9	4944	c.4626G>A	c.(4624-4626)agG>agA	p.R1542R		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1542					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						AACTCCGGAGGGATCTGATTT	0.567000													9	11					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20216109	20216109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20216109G>A	ENST00000418063.2	+	3	322	c.210G>A	c.(208-210)atG>atA	p.M70I	ZNF90_ENST00000474284.1_3'UTR	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	70	KRAB.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						GACATGAGATGATTGCCAAAT	0.408000													29	94					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135690087	135690087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135690087G>A	ENST00000298545.3	-	10	1438	c.917C>T	c.(916-918)gCt>gTt	p.A306V	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	306	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						ATCTGCCACAGCCTCTTTCAG	0.493000													16	53					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67686146	67686146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67686146C>T	ENST00000334583.6	+	27	3049	c.2721C>T	c.(2719-2721)gcC>gcT	p.A907A	RLTPR_ENST00000545661.1_Silent_p.A871A	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	907	Pro-rich.									breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		TGCCCCCTGCCCTACCAGCAC	0.567000													23	113					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705633	101705633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:101705633G>A	ENST00000305352.6	+	2	1468	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	365					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						CCAGAAAGACGAAGGGGACAA	0.547000													30	81					0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77475383	77475383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:77475383C>T	ENST00000299543.7	+	8	2070	c.1923C>T	c.(1921-1923)ttC>ttT	p.F641F	CTDP1_ENST00000075430.7_Silent_p.F641F	NM_001202504.1|NM_004715.4	NP_001189433.1|NP_004706.3	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	641	BRCT.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CCATAATTTTCAGTGGGCTAC	0.597000													4	13					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21015720	21015720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21015720C>T	ENST00000381545.3	+	8	878	c.659C>T	c.(658-660)cCa>cTa	p.P220L	SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000540229.1_Missense_Mutation_p.P220L|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.P220L|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.P220L	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	220					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATGATTGGTCCAGTCATTGGC	0.333000													19	134					0	0	1	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46387882	46387882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46387882G>A	ENST00000302165.3	-	1	1494	c.1151C>T	c.(1150-1152)tCc>tTc	p.S384F		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CGGCTCGGGGGATGCCTTGCG	0.746000													5	29					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129123150	129123150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129123150G>A	ENST00000505956.1	-	7	1508	c.1346C>T	c.(1345-1347)tCt>tTt	p.S449F	EFCAB12_ENST00000326085.3_Missense_Mutation_p.S449F	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		CAGATTCGGAGAAAAGACCTT	0.572000													34	90					0	0	1	0	0
NR2E1	7101	broad.mit.edu	37	6	108489317	108489317	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:108489317C>T	ENST00000368983.3	+	1	91	c.87C>T	c.(85-87)ttC>ttT	p.F29F	NR2E1_ENST00000368986.4_Intron			Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	0					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		GACTGGGTTTCCCTTTAGGCT	0.597000													4	10					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065577	55065577	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55065577C>T	ENST00000526016.1	-	0	131					NR_038174.2																						CATGTTGTCTCCTTGCATTTA	0.493000													13	30					0	0	1	0	0
GAA	2548	broad.mit.edu	37	17	78084749	78084749	+	Missense_Mutation	SNP	G	G	A	rs121907937		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78084749G>A	ENST00000302262.3	+	11	1780	c.1561G>A	c.(1561-1563)Gag>Aag	p.E521K	GAA_ENST00000390015.3_Missense_Mutation_p.E521K	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	521			E -> K (in GSD2; severe).		cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGACATGAACGAGCCTTCCAA	0.632000													7	59					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255810	15255810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15255810C>T	ENST00000378116.4	-	8	1783	c.1777G>A	c.(1777-1779)Gac>Aac	p.D593N		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	593						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TAGGAGTGGTCCCCGGGGAGT	0.542000													59	63					0	0	1	0	0
GABRD	2563	broad.mit.edu	37	1	1961051	1961051	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1961051G>A	ENST00000378585.4	+	8	992	c.909G>A	c.(907-909)cgG>cgA	p.R303R		NM_000815.4	NP_000806.2	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	303						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CCCTGCCACGGGCATCAGCCA	0.607000													9	39					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118165285	118165285	+	Missense_Mutation	SNP	C	C	T	rs148780595		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:118165285C>T	ENST00000427715.2	+	6	661	c.227C>T	c.(226-228)tCg>tTg	p.S76L	SLC30A8_ENST00000456015.2_Missense_Mutation_p.S125L|SLC30A8_ENST00000521243.1_Missense_Mutation_p.S76L|SLC30A8_ENST00000519688.1_Missense_Mutation_p.S76L	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	125					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity	p.S125*(2)		breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TGGTTGTCATCGAAGCCTCCC	0.527000													15	36					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51171299	51171299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51171299G>A	ENST00000440970.1	-	3	3839	c.3408C>T	c.(3406-3408)ttC>ttT	p.F1136F	SALL1_ENST00000566102.1_3'UTR|SALL1_ENST00000541611.1_Silent_p.F56F|SALL1_ENST00000251020.4_Silent_p.F1233F	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1233					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACTGATTCCAGAAGCTGGAAG	0.542000													15	36					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32280440	32280440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32280440C>T	ENST00000360482.2	-	2	624	c.495G>A	c.(493-495)agG>agA	p.R165R	SPOCD1_ENST00000533231.1_Silent_p.R165R|SPOCD1_ENST00000373648.2_Silent_p.R165R|SPOCD1_ENST00000257100.3_Intron	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	165					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CTCTGGCCTCCCTGGGCCTGA	0.617000													48	78					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186672571	186672571	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:186672571G>A	ENST00000343098.5	+	17	18805	c.18805G>A	c.(18805-18807)Gaa>Aaa	p.E6269K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E6180K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TAACATAATAGAAGAAATTGC	0.303000													16	48					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31318246	31318246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:31318246G>A	ENST00000380490.3	+	2	218	c.120G>A	c.(118-120)agG>agA	p.R40R	ALOX5AP_ENST00000479597.1_3'UTR	NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	40					cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		AGAATGGGAGGAGCTTCCAGA	0.542000													10	51					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220494887	220494887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220494887C>T	ENST00000358055.3	+	6	1136	c.624C>T	c.(622-624)ccC>ccT	p.P208P	SLC4A3_ENST00000373762.3_Silent_p.P235P|SLC4A3_ENST00000273063.6_Silent_p.P235P|SLC4A3_ENST00000497589.1_Intron|SLC4A3_ENST00000373760.2_Silent_p.P208P|SLC4A3_ENST00000317151.3_Silent_p.P208P			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	208					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCCAGCCCCCGGGCCCGGG	0.692000													3	15					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98592348	98592348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98592348C>T	ENST00000359863.4	+	66	10353	c.10144C>T	c.(10144-10146)Ctg>Ttg	p.L3382L	TRRAP_ENST00000355540.3_Silent_p.L3353L|TRRAP_ENST00000446306.3_Silent_p.L3371L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3382					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGGGTGGGCCTGGAGAATGT	0.567000													86	192					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174869243	174869243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:174869243G>A	ENST00000393752.2	-	2	1852	c.860C>T	c.(859-861)cCt>cTt	p.P287L		NM_000794.3	NP_000785.1	P21728	DRD1_HUMAN	dopamine receptor D1	287					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	GATGAAGAAAGGTAGCCAACA	0.463000													14	34					0	0	1	0	0
MAPK7	5598	broad.mit.edu	37	17	19286458	19286458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:19286458C>T	ENST00000308406.5	+	7	2751	c.2365C>T	c.(2365-2367)Cct>Tct	p.P789S	MAPK7_ENST00000395604.3_Missense_Mutation_p.P789S|MAPK7_ENST00000395602.4_Missense_Mutation_p.P789S|MAPK7_ENST00000571657.1_3'UTR|MAPK7_ENST00000299612.7_Missense_Mutation_p.P650S	NM_139033.2	NP_620602.2	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7	789	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					TGGCATGAACCCTGCCGATAT	0.612000													24	28					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764842	77764842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77764842C>T	ENST00000521891.2	+	10	6133	c.5685C>T	c.(5683-5685)atC>atT	p.I1895I	ZFHX4_ENST00000455469.2_Silent_p.I1850I|ZFHX4_ENST00000050961.6_Silent_p.I1850I|ZFHX4_ENST00000518282.1_Silent_p.I1869I	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1850						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACCATCCATCCCACCACCCC	0.433000										HNSCC(33;0.089)			8	16					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20216065	20216065	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20216065C>T	ENST00000418063.2	+	3	278	c.166C>T	c.(166-168)Ctg>Ttg	p.L56L	ZNF90_ENST00000474284.1_3'UTR	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	56	KRAB.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						GATCACCTGTCTGGAGCAAGG	0.388000													36	93					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32137577	32137577	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32137577C>T	ENST00000312561.4	+	4	4102	c.3688C>T	c.(3688-3690)Caa>Taa	p.Q1230*	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		CACTGTTGTTCAATTTAAGAG	0.378000													26	54					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256729	140256729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140256729G>A	ENST00000398631.2	+	1	1672	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCTGGACGAGAACGACAA	0.701000													66	153					0	0	1	0	0
DOK3	79930	broad.mit.edu	37	5	176931397	176931397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176931397G>A	ENST00000501403.2	-	6	1259	c.910C>T	c.(910-912)Ccc>Tcc	p.P304S	DOK3_ENST00000357198.4_Missense_Mutation_p.P360S|DOK3_ENST00000377112.4_Intron|DOK3_ENST00000312943.6_Intron			Q7L591	DOK3_HUMAN	docking protein 3	360	IRS-type PTB.					cytoplasm|plasma membrane	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|lung(7)	13	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TGGGGTCCGGGCTCGGCCAGG	0.687000													4	25					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180064816	180064816	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:180064816G>A	ENST00000367607.3	+	35	9088	c.8670G>A	c.(8668-8670)aaG>aaA	p.K2890K	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2890						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AAAAAAATAAGGCAGAAGAAA	0.433000													21	54					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676126	123676126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123676126C>T	ENST00000309154.2	-	1	969	c.932G>A	c.(931-933)aGg>aAg	p.R311K		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		TCAAGTTTTCCTTTGTATCAA	0.378000													10	129					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582507	136582507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136582507G>A	ENST00000531224.1	-	12	2905	c.2653C>T	c.(2653-2655)Cct>Tct	p.P885S	BCLAF1_ENST00000527536.1_Missense_Mutation_p.P836S|BCLAF1_ENST00000527759.1_Missense_Mutation_p.P883S|BCLAF1_ENST00000031135.9_Missense_Mutation_p.P103S|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000392348.2_Missense_Mutation_p.P834S|BCLAF1_ENST00000530767.1_Missense_Mutation_p.P712S|BCLAF1_ENST00000353331.4_Missense_Mutation_p.P834S	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	885					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GTCCATTTAGGACTGCTACCT	0.433000													58	293					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96239919	96239919	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:96239919G>A	ENST00000347108.3	-	18	2524	c.2092C>T	c.(2092-2094)Cca>Tca	p.P698S	DZIP1_ENST00000361396.2_Missense_Mutation_p.P679S|DZIP1_ENST00000376829.2_Missense_Mutation_p.P698S|DZIP1_ENST00000361156.3_Missense_Mutation_p.P679S			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	698					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AGTGGGCCTGGGGATGCGTAT	0.572000													18	44					0	0	1	0	0
OR5B2	390190	broad.mit.edu	37	11	58189862	58189862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58189862C>T	ENST00000302581.2	-	1	924	c.873G>A	c.(871-873)agG>agA	p.R291R		NM_001005566.2	NP_001005566.1	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B, member 2	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTTCTCTGTTCCTCAGGCTGT	0.418000													32	62					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131755565	131755565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:131755565C>T	ENST00000368648.3	-	6	583	c.511G>A	c.(511-513)Ggc>Agc	p.G171S	EBF3_ENST00000355311.5_Missense_Mutation_p.G171S	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	171					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		TTTCTATTGCCACAACTTTTC	0.388000													28	104					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33586675	33586675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33586675G>A	ENST00000262873.7	+	33	4365	c.4273G>A	c.(4273-4275)Gaa>Aaa	p.E1425K		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1383						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GAGCAAGTACGAAGCAGATGC	0.637000													17	42					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174243	51174243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51174243G>A	ENST00000440970.1	-	2	2030	c.1599C>T	c.(1597-1599)gtC>gtT	p.V533V	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.V630V	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	630					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTGAGTTGGTGACCATGCCAC	0.637000													16	54					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364116	5364116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5364116G>A	ENST00000300773.2	-	1	693	c.639C>T	c.(637-639)ttC>ttT	p.F213F	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATAGGAGATGAAGATAATCA	0.468000													38	83					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17476486	17476486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17476486G>A	ENST00000252590.4	-	3	849	c.788C>T	c.(787-789)tCg>tTg	p.S263L		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	263						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGCCAATTCCGAGCCCAGGGG	0.602000													11	89					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108076871	108076871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108076871C>T	ENST00000357759.5	+	6	1280	c.866C>T	c.(865-867)tCa>tTa	p.S289L	HHLA2_ENST00000467761.1_Missense_Mutation_p.S289L|HHLA2_ENST00000467562.1_Missense_Mutation_p.S225L|HHLA2_ENST00000489514.2_Missense_Mutation_p.S289L|HHLA2_ENST00000491820.1_Missense_Mutation_p.S289L	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	289	Ig-like V-type 2.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						TCCCGATTCTCATGGAACAAA	0.373000													44	166					0	0	1	0	0
TSPAN18	90139	broad.mit.edu	37	11	44948236	44948236	+	Silent	SNP	G	G	A	rs149091051	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:44948236G>A	ENST00000340160.3	+	8	866	c.627G>A	c.(625-627)acG>acA	p.T209T	TSPAN18_ENST00000520358.2_Silent_p.T209T	NM_130783.4	NP_570139.3	Q96SJ8	TSN18_HUMAN	tetraspanin 18	209						integral to membrane				endometrium(1)|large_intestine(6)|lung(3)	10						GCTGTTACACGGTGATCCTCA	0.587000											OREG0020922	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	123					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117669776	117669776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117669776G>A	ENST00000317775.6	-	22	4081	c.3396C>T	c.(3394-3396)gtC>gtT	p.V1132V	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.V1166V	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1132	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCTTGCTGAGGACCAGCAGAC	0.557000													10	17					0	0	1	0	0
SSUH2	51066	broad.mit.edu	37	3	8675522	8675522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:8675522G>A	ENST00000317371.4	-	11	1328	c.103C>T	c.(103-105)Cct>Tct	p.P35S	SSUH2_ENST00000544814.1_Intron|SSUH2_ENST00000341795.3_Missense_Mutation_p.P35S|SSUH2_ENST00000415132.1_Missense_Mutation_p.P35S					ssu-2 homolog (C. elegans)																		TTCTGGGAAGGGCCTGTGGAC	0.647000													8	14					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186445073	186445073	+	Silent	SNP	G	G	A	rs142183659		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186445073G>A	ENST00000265023.4	+	5	824	c.612G>A	c.(610-612)acG>acA	p.T204T	RP11-573D15.8_ENST00000599314.1_RNA|KNG1_ENST00000447445.1_Intron|KNG1_ENST00000287611.2_Silent_p.T204T	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	204	Cystatin 2.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	TTGTGCAAACGAATTGTTCCA	0.348000													16	97					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17698997	17698997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:17698997G>A	ENST00000399080.2	-	1	709	c.686C>T	c.(685-687)tCa>tTa	p.S229L		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	229										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TAGTACAGATGATGAAATGTT	0.338000													17	69					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52858009	52858009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52858009G>A	ENST00000266041.4	-	10	1279	c.1183C>T	c.(1183-1185)Ccc>Tcc	p.P395S	ITIH4_ENST00000485816.1_Missense_Mutation_p.P395S|ITIH4_ENST00000406595.1_Missense_Mutation_p.P395S|ITIH4_ENST00000346281.5_Missense_Mutation_p.P395S|ITIH4_ENST00000434759.3_Missense_Mutation_p.P307S|ITIH4-AS1_ENST00000478366.1_RNA	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	395	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		ATGCTCCTGGGGTTAGTCTCC	0.542000													15	50					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75136681	75136681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75136681G>A	ENST00000356357.4	-	14	2272	c.1757C>T	c.(1756-1758)gCc>gTc	p.A586V	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		TATGATTTGGGCCAGGAAAGA	0.542000													32	87					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184632794	184632794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184632794C>T	ENST00000287546.4	+	26	2386	c.2215C>T	c.(2215-2217)Ccc>Tcc	p.P739S	VPS8_ENST00000436792.2_Missense_Mutation_p.P737S|VPS8_ENST00000446204.2_Missense_Mutation_p.P647S|VPS8_ENST00000437079.3_Missense_Mutation_p.P739S	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	739							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TCGTGCCTATCCCCTTGGTGA	0.428000													22	73					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	782336	782336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:782336G>A	ENST00000540986.1	-	7	1990	c.555C>T	c.(553-555)tcC>tcT	p.S185S	NARFL_ENST00000251588.2_Silent_p.S287S|NARFL_ENST00000562862.1_5'UTR|NARFL_ENST00000301694.5_3'UTR|NARFL_ENST00000568545.1_Silent_p.S185S			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	287					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				GGTCGGGGAGGGAGACGCCCT	0.532000													66	161					0	0	1	0	0
FBLN7	129804	broad.mit.edu	37	2	112944888	112944888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:112944888C>T	ENST00000331203.2	+	8	1396	c.1125C>T	c.(1123-1125)atC>atT	p.I375I	FBLN7_ENST00000409903.1_Intron|FBLN7_ENST00000409450.3_Silent_p.I329I|FBLN7_ENST00000409667.3_Silent_p.I241I	NM_001128165.1|NM_153214.2	NP_001121637.1|NP_694946.2	Q53RD9	FBLN7_HUMAN	fibulin 7	375					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GGTTTGGGATCGTGGGTGGGA	0.642000													56	101					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156741403	156741403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156741403G>A	ENST00000347377.6	+	12	1593	c.1162G>A	c.(1162-1164)Gag>Aag	p.E388K	CYFIP2_ENST00000377576.3_Missense_Mutation_p.E388K|CYFIP2_ENST00000318218.6_Missense_Mutation_p.E388K|CYFIP2_ENST00000541131.1_Missense_Mutation_p.E313K|CYFIP2_ENST00000522463.1_Missense_Mutation_p.E192K|CYFIP2_ENST00000521420.1_Missense_Mutation_p.E362K|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Missense_Mutation_p.E62K	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	388					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGAGTATCGCGAGCTCTTCGA	0.587000													29	67					0	0	1	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940338	67940338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:67940338G>A	ENST00000357461.2	-	3	712	c.303C>T	c.(301-303)tgC>tgT	p.C101C	TMEM229B_ENST00000557006.1_Silent_p.C101C	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	101						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						AGTCCCAGGGGCAGGCGTTGA	0.632000													4	8					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49869412	49869412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49869412G>A	ENST00000331456.2	-	11	1087	c.974C>T	c.(973-975)cCc>cTc	p.P325L	TRAIP_ENST00000469027.1_Missense_Mutation_p.P170L	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	325	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCGGGCTGGGGGAGTATCCAC	0.547000													29	67					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40044087	40044087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40044087G>A	ENST00000373233.3	-	34	6855	c.6678C>T	c.(6676-6678)tcC>tcT	p.S2226S		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2226					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TGGCTCCTGGGGACCCCTCTG	0.597000													8	12					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15688901	15688901	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15688901C>T	ENST00000378076.3	-	12	1504	c.1151G>A	c.(1150-1152)gGg>gAg	p.G384E		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	384					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	p.G384L(1)		NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						ACCGAATCTCCCAAACGTCTC	0.483000													15	51					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3845280	3845280	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3845280C>T	ENST00000400147.2	-	1	79	c.3G>A	c.(1-3)atG>atA	p.M1I	DLGAP1_ENST00000400149.3_Intron|DLGAP1_ENST00000581699.1_Intron|DLGAP1_ENST00000315677.3_Intron|DLGAP1_ENST00000400150.3_Intron|DLGAP1_ENST00000400145.2_Start_Codon_SNP_p.M1I|DLGAP1_ENST00000581527.1_Intron|DLGAP1_ENST00000539435.1_Start_Codon_SNP_p.M1I|DLGAP1_ENST00000478161.1_Intron|DLGAP1_ENST00000400155.1_Intron|DLGAP1_ENST00000534970.1_Intron|DLGAP1_ENST00000515196.2_Intron|DLGAP1_ENST00000584874.1_Intron	NM_001003809.2	NP_001003809.1	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	0					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.M1I(2)		breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				AAATTAAGTTCATTATTCATC	0.368000													15	58					0	0	1	0	0
API5	8539	broad.mit.edu	37	11	43342980	43342980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:43342980C>T	ENST00000378852.3	+	4	470	c.345C>T	c.(343-345)aaC>aaT	p.N115N	API5_ENST00000534600.1_Silent_p.N115N|API5_ENST00000531273.1_Silent_p.N115N|API5_ENST00000455725.2_Silent_p.N104N|API5_ENST00000534695.1_Intron|API5_ENST00000420461.2_Silent_p.N61N	NM_001142930.1|NM_006595.3	NP_001136402.1|NP_006586.1	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	115					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						CAGAATTTAACCTAGTGAACA	0.303000													19	45					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	31498133	31498133	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:31498133C>T	ENST00000520407.1	+	1	863	c.633C>T	c.(631-633)ccC>ccT	p.P211P	NRG1_ENST00000519301.1_Intron	NM_013962.2	NP_039256.2	Q02297	NRG1_HUMAN	neuregulin 1	594	EGF-like.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TCATGGAGCCCGACGCCAACA	0.687000													8	44					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72338188	72338188	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72338188C>T	ENST00000333850.3	+	3	511	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	TPH2_ENST00000546576.1_3'UTR	NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	124	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	TGAGCTCATTCAGTTGCTGAA	0.433000													28	117					0	0	1	0	0
GPR27	2850	broad.mit.edu	37	3	71804292	71804292	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:71804292G>A	ENST00000304411.2	+	1	1092	c.1092G>A	c.(1090-1092)gcG>gcA	p.A364A		NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	364						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CCACCCAGGCGACCCATCCCT	0.632000													9	21					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58118530	58118530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58118530C>T	ENST00000332854.6	+	3	1857	c.1637C>T	c.(1636-1638)cCt>cTt	p.P546L	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGAGAAAGGCCTTATGAGTGC	0.448000													11	136					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65180891	65180891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:65180891G>A	ENST00000310045.7	-	2	2458	c.985C>T	c.(985-987)Ctt>Ttt	p.L329F	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	319						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				CCAGGTAAAAGGGTGGCATAA	0.383000													15	123					0	0	1	0	0
SLC17A3	10786	broad.mit.edu	37	6	25850805	25850805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25850805C>T	ENST00000397060.4	-	8	984	c.875G>A	c.(874-876)aGa>aAa	p.R292K	SLC17A3_ENST00000361703.6_Missense_Mutation_p.R214K|SLC17A3_ENST00000360657.3_Missense_Mutation_p.R214K	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	214					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						GGGTAGAGATCTGAGCATAGC	0.423000													20	82					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032418	142032418	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142032418C>T	ENST00000547918.2	+	0	271																											ATCGGGGCTTCCCCGTGATCG	0.552000													14	16					0	0	1	0	0
ZNF391	346157	broad.mit.edu	37	6	27368311	27368311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:27368311C>T	ENST00000244576.4	+	3	707	c.162C>T	c.(160-162)ttC>ttT	p.F54F		NM_001076781.1	NP_001070249.1	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(6)|lung(7)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	21						AAGAAATTTTCACAGGGGAGG	0.428000													26	77					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646757	57646757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57646757G>A	ENST00000269834.1	-	5	1333	c.948C>T	c.(946-948)ttC>ttT	p.F316F		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTTGTAAATGAAAGCCTTTC	0.403000													52	128					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152518823	152518823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152518823C>T	ENST00000427231.2	-	46	5998	c.5796G>A	c.(5794-5796)atG>atA	p.M1932I	NEB_ENST00000604864.1_Missense_Mutation_p.M1932I|NEB_ENST00000603639.1_Missense_Mutation_p.M1932I|NEB_ENST00000172853.10_Missense_Mutation_p.M1932I|NEB_ENST00000397345.3_Missense_Mutation_p.M1932I|NEB_ENST00000409198.1_Missense_Mutation_p.M1932I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1932					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAATGCCCTTCATGAAGTCAG	0.433000													16	120					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40364092	40364092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40364092G>A	ENST00000221347.6	-	31	14557	c.14550C>T	c.(14548-14550)gcC>gcT	p.A4850A		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4850						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CACAGCCTGTGGCATGACAGG	0.647000													12	51					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8069746	8069746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:8069746C>T	ENST00000332175.8	+	8	2232	c.1195C>T	c.(1195-1197)Cgc>Tgc	p.R399C	PTPRM_ENST00000400053.4_Missense_Mutation_p.R337C|PTPRM_ENST00000444013.1_Missense_Mutation_p.R186C|PTPRM_ENST00000578571.1_3'UTR|PTPRM_ENST00000580170.1_Missense_Mutation_p.R399C|PTPRM_ENST00000400060.4_Missense_Mutation_p.R399C	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	399	Fibronectin type-III 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				AATCACTATCCGCTGGGAGCC	0.423000													18	48					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32585567	32585567	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:32585567C>T	ENST00000341377.5	+	6	1120	c.603C>T	c.(601-603)gaC>gaT	p.D201D	NRG1_ENST00000287840.5_Silent_p.D201D|NRG1_ENST00000539990.1_Silent_p.D47D|NRG1_ENST00000520407.1_Silent_p.D382D|NRG1_ENST00000405005.2_Silent_p.D201D|NRG1_ENST00000287845.5_Silent_p.D167D|NRG1_ENST00000287842.3_Silent_p.D201D|NRG1_ENST00000338921.4_Silent_p.D201D|NRG1_ENST00000520502.2_Silent_p.D256D|NRG1_ENST00000523079.1_Silent_p.D201D|NRG1_ENST00000356819.4_Silent_p.D201D|NRG1_ENST00000521670.1_Silent_p.D201D|NRG1_ENST00000519301.1_Silent_p.D146D			Q02297	NRG1_HUMAN	neuregulin 1	201	EGF-like.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGGTGAAAGACCTTTCAAACC	0.423000													25	92					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100380924	100380924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100380924G>A	ENST00000262233.6	+	15	1781	c.1642G>A	c.(1642-1644)Gga>Aga	p.G548R	EML1_ENST00000327921.9_Missense_Mutation_p.G536R|EML1_ENST00000334192.4_Missense_Mutation_p.G567R	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	548						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TGAGCTCTGGGGACTGGCCAT	0.537000													6	46					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101680176	101680176	+	Missense_Mutation	SNP	C	C	T	rs147399996		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101680176C>T	ENST00000261637.4	+	5	578	c.404C>T	c.(403-405)tCg>tTg	p.S135L		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	135					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding	p.S135L(1)		NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						ACTATCACCTCGATCCTGGAG	0.423000													84	199					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220107272	220107272	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220107272G>A	ENST00000295759.7	-	5	728	c.415C>T	c.(415-417)Cga>Tga	p.R139*	GLB1L_ENST00000409640.1_Nonsense_Mutation_p.R139*|GLB1L_ENST00000356283.3_Nonsense_Mutation_p.R139*|GLB1L_ENST00000392089.2_Nonsense_Mutation_p.R139*			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	139					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAGGTTTTCGAAGCAACCAG	0.443000													48	105					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084910	53084910	+	Missense_Mutation	SNP	G	G	A	rs140839383		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:53084910G>A	ENST00000276480.7	-	10	1194	c.511C>T	c.(511-513)Cat>Tat	p.H171Y		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	171						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCATCAGAATGAATCAGAAAG	0.403000													31	55					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83591047	83591047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83591047C>T	ENST00000265362.3	-	17	2270	c.1956G>A	c.(1954-1956)gtG>gtA	p.V652V	SEMA3A_ENST00000436949.1_Silent_p.V652V	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	652	Ig-like C2-type.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						ACCCATGTTCCACCGCATGGC	0.438000													28	82					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202060586	202060586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202060586C>T	ENST00000286186.6	+	5	1034	c.599C>T	c.(598-600)cCt>cTt	p.P200L	CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000374650.3_Missense_Mutation_p.P200L|CASP10_ENST00000360132.3_Missense_Mutation_p.P200L|CASP10_ENST00000313728.7_Missense_Mutation_p.P200L|CASP10_ENST00000272879.5_Missense_Mutation_p.P200L|CASP10_ENST00000448480.1_Missense_Mutation_p.P200L|CASP10_ENST00000346817.5_Missense_Mutation_p.P200L	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	200					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						GTGACACCTCCTGTAGACAAG	0.443000													72	166					0	0	1	0	0
CYP2S1	29785	broad.mit.edu	37	19	41704713	41704713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41704713G>A	ENST00000310054.4	+	5	970	c.754G>A	c.(754-756)Gtg>Atg	p.V252M	CYP2S1_ENST00000542619.1_Intron	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	252					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						AGTCCGGCAGGTGCAGCAGCA	0.642000													29	64					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6477836	6477836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6477836G>A	ENST00000525074.1	-	6	1514	c.1120C>T	c.(1120-1122)Ctt>Ttt	p.L374F	TRIM3_ENST00000345851.3_Missense_Mutation_p.L374F|TRIM3_ENST00000536344.1_Missense_Mutation_p.L255F|TRIM3_ENST00000529058.1_5'UTR|TRIM3_ENST00000359518.3_Missense_Mutation_p.L374F|TRIM3_ENST00000537602.1_Missense_Mutation_p.L296F	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	374					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCACCGGAAGGCGCGTGCCG	0.632000													13	41					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65490231	65490231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65490231C>T	ENST00000261883.4	-	9	2559	c.2393G>A	c.(2392-2394)aGt>aAt	p.S798N		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	798					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TGTGATGACACTGTCAAAGCG	0.587000													16	135					0	0	1	0	0
C1orf64	149563	broad.mit.edu	37	1	16332591	16332591	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16332591A>G	ENST00000329454.2	+	2	328	c.260A>G	c.(259-261)gAa>gGa	p.E87G		NM_178840.2	NP_849162.1	Q8NEQ6	CA064_HUMAN	chromosome 1 open reading frame 64	87										breast(2)|endometrium(1)|lung(3)	6		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTGTGGGGAAAACTGGCCC	0.642000													55	98					0	0	1	0	0
LAMP1	3916	broad.mit.edu	37	13	113973849	113973849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113973849C>T	ENST00000332556.4	+	5	822	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S	LAMP1_ENST00000397181.3_Missense_Mutation_p.P157S	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	210	Hinge.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			CAGCCCCTCGCCCTCACCCGT	0.652000													16	52					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61513219	61513219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61513219G>A	ENST00000266070.4	-	16	4414	c.4089C>T	c.(4087-4089)atC>atT	p.I1363I	DIDO1_ENST00000395343.1_Silent_p.I1363I	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1363					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					ACTGCTGGACGATCGGATCTA	0.622000													57	128					0	0	1	0	0
AK1	203	broad.mit.edu	37	9	130630339	130630339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130630339G>A	ENST00000373176.1	-	7	685	c.533C>T	c.(532-534)tCc>tTc	p.S178F	AK1_ENST00000223836.10_Missense_Mutation_p.S194F|RP11-203J24.9_ENST00000476274.2_RNA|AK1_ENST00000373156.1_Missense_Mutation_p.S178F	NM_000476.2	NP_000467.1	P00568	KAD1_HUMAN	adenylate kinase 1	178					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding			endometrium(1)|prostate(1)	2						ACTGTCCACGGAGCCCTCAGC	0.677000													27	50					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966705	41966705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41966705G>A	ENST00000298919.7	+	10	1732	c.1344G>A	c.(1342-1344)cgG>cgA	p.R448R	PDZRN4_ENST00000539469.2_Silent_p.R450R|PDZRN4_ENST00000402685.2_Silent_p.R708R			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	708	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding	p.R450R(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAGGATTCCGGAATTATAACA	0.448000													7	120					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56935685	56935685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56935685C>T	ENST00000333201.9	+	5	1868	c.1658C>T	c.(1657-1659)cCc>cTc	p.P553L	ZNF583_ENST00000585612.1_Intron|ZNF583_ENST00000291598.7_Missense_Mutation_p.P553L	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	553					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		ctttcctctccctcaccctcc	0.423000													13	23					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61040427	61040427	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61040427G>A	ENST00000252997.2	-	6	1068	c.1007C>T	c.(1006-1008)cCa>cTa	p.P336L		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	336					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			AGGGCACACTGGGGACGCCAG	0.672000													7	19					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404084	124404084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:124404084G>A	ENST00000303921.2	-	1	1597	c.947C>T	c.(946-948)cCg>cTg	p.P316L		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	316						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GATGACCAGCGGAAGGCAGAA	0.532000													63	134					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207881565	207881565	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207881565G>A	ENST00000508064.2	+	10	1431	c.1371G>A	c.(1369-1371)tcG>tcA	p.S457S	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	457	Sushi 7.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GTATCCTCTCGGGCAATACTG	0.453000													40	183					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169535587	169535587	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169535587T>C	ENST00000449804.2	+	2	869	c.824T>C	c.(823-825)cTc>cCc	p.L275P	FOXI1_ENST00000306268.6_Missense_Mutation_p.L370P	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	370					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTGGTGTCCTCTACCCCAGG	0.572000									Pendred syndrome				35	86					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240774	126240774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126240774G>A	ENST00000394329.3	+	1	3221	c.3208G>A	c.(3208-3210)Gtt>Att	p.V1070I		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1070	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGTTTTAATGGTTGTTGCTTC	0.373000													68	172					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901844	51901844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:51901844G>A	ENST00000268919.4	+	1	1606	c.1450G>A	c.(1450-1452)Gct>Act	p.A484T		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	484					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ATGTATTCTGGCTTTGGGTCA	0.507000													8	37					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21213314	21213314	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21213314C>T	ENST00000574002.1	-	13	1800	c.1318G>A	c.(1318-1320)Gaa>Aaa	p.E440K	ZP2_ENST00000219593.4_Missense_Mutation_p.E440K|ZP2_ENST00000574091.1_Missense_Mutation_p.E440K|AF001550.7_ENST00000572747.1_RNA			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	440	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		GCATGTATTTCGTTTTCATAG	0.393000													32	113					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008510	120008510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120008510C>T	ENST00000341846.5	-	1	651	c.230G>A	c.(229-231)cGa>cAa	p.R77Q		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	77					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R77L(2)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GATGATGGGTCGCCGCCACTC	0.637000													81	189					0	0	1	0	0
OPN4	94233	broad.mit.edu	37	10	88417801	88417801	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88417801C>T	ENST00000372071.2	+	4	563	c.336C>T	c.(334-336)ctC>ctT	p.L112L	OPN4_ENST00000241891.5_Silent_p.L101L	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	101					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						GCAGAAGCCTCCGGACACCTG	0.562000													7	92					0	0	1	0	0
LEKR1	389170	broad.mit.edu	37	3	156711020	156711020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:156711020C>T	ENST00000470811.1	+	10	1486	c.151C>T	c.(151-153)Ctt>Ttt	p.L51F	LEKR1_ENST00000356539.4_Missense_Mutation_p.L355F			D3DNK7	D3DNK7_HUMAN	leucine, glutamate and lysine rich 1	64										breast(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	11			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AACCAAAACTCTTCTGAATCA	0.323000													10	112					0	0	1	0	0
OR2T8	343172	broad.mit.edu	37	1	248085211	248085211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248085211G>A	ENST00000319968.4	+	1	892	c.892G>A	c.(892-894)Gcc>Acc	p.A298T		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGTGAAGGGAGCCCTGACAAG	0.453000													51	129					0	0	1	0	0
KLF4	9314	broad.mit.edu	37	9	110249798	110249798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:110249798G>A	ENST00000374672.4	-	3	1350	c.877C>T	c.(877-879)Cct>Tct	p.P293S		NM_004235.4	NP_004226.3	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	293	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(5)|large_intestine(1)|lung(3)|pancreas(1)|prostate(2)	16						TTGCTGAGAGGGGGTCCAGCG	0.701000													4	17					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74082501	74082501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74082501G>A	ENST00000443185.2	-	7	3731	c.3414C>T	c.(3412-3414)tcC>tcT	p.S1138S	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	1138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGGCGTCTGCGGAGGTGGTAT	0.527000													6	16					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423265	56423265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56423265G>A	ENST00000588751.1	-	5	1942	c.1918C>T	c.(1918-1920)Cac>Tac	p.H640Y	NLRP13_ENST00000342929.3_Missense_Mutation_p.H640Y			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	640							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TGTAGGCAGTGAAAAAGTCGT	0.423000													40	79					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216837	21216837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21216837C>T	ENST00000380216.1	-	1	473	c.468G>A	c.(466-468)ggG>ggA	p.G156G		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	156					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TGTATTTCTTCCCCATCAGAT	0.438000													44	403					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75329450	75329450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75329450G>A	ENST00000556489.2	-	1	1087	c.1088C>T	c.(1087-1089)cCt>cTt	p.P363L	PROX2_ENST00000556084.2_Intron|PROX2_ENST00000445876.1_Missense_Mutation_p.P363L	NM_001243007.1	NP_001229936.1	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	363					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GTCCTGGGGAGGACTGCTACT	0.537000													15	31					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72955525	72955525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:72955525C>T	ENST00000264839.7	+	11	2089	c.2089C>T	c.(2089-2091)Ccc>Tcc	p.P697S	RIMS1_ENST00000401910.3_Missense_Mutation_p.P171S|RIMS1_ENST00000348717.5_Missense_Mutation_p.P697S|RIMS1_ENST00000520567.1_Missense_Mutation_p.P697S|RIMS1_ENST00000523963.1_Missense_Mutation_p.P171S|RIMS1_ENST00000517960.1_Missense_Mutation_p.P697S|RIMS1_ENST00000521978.1_Missense_Mutation_p.P697S|RIMS1_ENST00000522291.1_Missense_Mutation_p.P697S|RIMS1_ENST00000517827.1_Missense_Mutation_p.P156S|RIMS1_ENST00000518273.1_Missense_Mutation_p.P697S|RIMS1_ENST00000491071.2_Missense_Mutation_p.P697S|RIMS1_ENST00000425662.2_Missense_Mutation_p.P90S			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	697					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TAGTGACATTCCCCGGATTCC	0.393000													22	45					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67016572	67016572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67016572G>A	ENST00000340001.4	-	19	2768	c.2557C>T	c.(2557-2559)Cgc>Tgc	p.R853C	ABCA9_ENST00000370732.2_Missense_Mutation_p.R853C|ABCA9_ENST00000453985.2_Missense_Mutation_p.R853C	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	853					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TTTAGGAAGCGAACTTTTGCT	0.398000													49	116					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183196718	183196718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183196718G>A	ENST00000264144.4	+	10	1419	c.1354G>A	c.(1354-1356)Gat>Aat	p.D452N	LAMC2_ENST00000493293.1_Missense_Mutation_p.D452N	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	452	Laminin EGF-like 5.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						TTTCTACAACGATCCGCACGA	0.557000													61	141					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8692525	8692525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8692525G>A	ENST00000299663.3	-	2	221	c.56C>T	c.(55-57)tCc>tTc	p.S19F	CLEC4E_ENST00000545274.1_Missense_Mutation_p.S19F|CLEC4E_ENST00000446457.2_Missense_Mutation_p.S19F	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	19						integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					GAACATTTGGGAAGAGAAGCA	0.403000													38	144					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147381126	147381126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:147381126G>A	ENST00000240986.4	+	2	1097	c.1044G>A	c.(1042-1044)gaG>gaA	p.E348E	GJA8_ENST00000369235.1_Silent_p.E348E	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	348					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					AGGTGGGAGAGAAGAAGGAGG	0.637000													3	10					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644533	169644533	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169644533G>A	ENST00000428432.2	+	6	872	c.483G>A	c.(481-483)caG>caA	p.Q161Q	SAMD7_ENST00000335556.3_Silent_p.Q161Q	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	161										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GAAACCTTCAGGGAAACCCCA	0.562000													49	83					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47031040	47031040	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47031040C>T	ENST00000450053.3	+	6	692	c.513C>T	c.(511-513)ttC>ttT	p.F171F	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Silent_p.F171F	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	171							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		AATACAAGTTCCCTCCTGCTG	0.622000													5	12					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207025	58207025	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58207025C>T	ENST00000377918.3	+	1	371	c.345C>T	c.(343-345)atC>atT	p.I115I		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	115	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ACAAGGAGATCTGCATGATCA	0.592000													14	26					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99514193	99514193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:99514193G>A	ENST00000261037.3	+	5	1828	c.1448G>A	c.(1447-1449)gGa>gAa	p.G483E	COL8A1_ENST00000273342.4_Missense_Mutation_p.G483E	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	483	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGACCTAAGGGAGAGCCAGGA	0.627000													4	9					0	0	1	0	0
CRHBP	1393	broad.mit.edu	37	5	76249004	76249004	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76249004C>T	ENST00000274368.4	+	1	467	c.45C>T	c.(43-45)ttC>ttT	p.F15F	CRHBP_ENST00000506501.1_Silent_p.F15F	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	15					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		TTCTCATCTTCCTGACGGCTC	0.582000													16	44					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125512489	125512489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125512489C>T	ENST00000373684.1	+	1	471	c.471C>T	c.(469-471)atC>atT	p.I157I	OR1L6_ENST00000304720.2_Silent_p.I121I			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						CTATGGCCATCGACCGGCTGG	0.527000													20	143					0	0	1	0	0
EFCAB11	90141	broad.mit.edu	37	14	90397920	90397920	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90397920G>A	ENST00000316738.7	-	5	403	c.375C>T	c.(373-375)ccC>ccT	p.P125P	EFCAB11_ENST00000267544.9_Silent_p.P62P|EFCAB11_ENST00000550103.2_5'UTR|EFCAB11_ENST00000556005.1_Silent_p.P101P|EFCAB11_ENST00000538485.2_Silent_p.P125P|EFCAB11_ENST00000555872.1_Silent_p.P101P|RP11-33N16.3_ENST00000555070.1_RNA|EFCAB11_ENST00000556609.1_Silent_p.P77P	NM_145231.2	NP_660274.1	Q9BUY7	EFC11_HUMAN	EF-hand calcium binding domain 11	125	EF-hand 2.						calcium ion binding			large_intestine(1)|lung(1)	2						CCGGTAATTTGGGAGCCACCT	0.333000													54	116					0	0	1	0	0
ZNF599	148103	broad.mit.edu	37	19	35251398	35251398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35251398G>A	ENST00000329285.7	-	4	681	c.308C>T	c.(307-309)tCt>tTt	p.S103F		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TTCCTGGAAAGAGGATTCCTC	0.428000													30	65					0	0	1	0	0
TMEM19	55266	broad.mit.edu	37	12	72092736	72092736	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72092736T>C	ENST00000266673.5	+	5	1288	c.694T>C	c.(694-696)Ttt>Ctt	p.F232L	RP11-293I14.2_ENST00000548802.1_3'UTR|TMEM19_ENST00000549735.1_Missense_Mutation_p.F232L	NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	232						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		TGGTGGTACCTTTGTGGGCAT	0.453000													61	104					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49898976	49898976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49898976C>T	ENST00000477224.1	-	5	815	c.337G>A	c.(337-339)Gac>Aac	p.D113N	CAMKV_ENST00000488336.1_Missense_Mutation_p.D113N|CAMKV_ENST00000463537.1_Missense_Mutation_p.D113N|CAMKV_ENST00000296471.7_Missense_Mutation_p.D113N|CAMKV_ENST00000467248.1_Missense_Mutation_p.D38N|CAMKV_ENST00000466940.1_Intron|CAMKV_ENST00000498324.1_5'UTR			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	113	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TAGCCCTGGTCCAGGATCCAG	0.612000													20	60					0	0	1	0	0
COPS2	9318	broad.mit.edu	37	15	49431756	49431756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:49431756G>A	ENST00000388901.5	-	4	414	c.341C>T	c.(340-342)tCt>tTt	p.S114F	COPS2_ENST00000542928.1_Missense_Mutation_p.S50F|COPS2_ENST00000299259.6_Missense_Mutation_p.S114F	NM_001143887.1|NM_004236.3	NP_001137359.1|NP_004227.1	P61201	CSN2_HUMAN	COP9 signalosome subunit 2	114					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(2)	18		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		ATCAAGAATAGAATTAATGGA	0.328000													34	89					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5282933	5282933	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5282933G>A	ENST00000546004.1	-	3	1154	c.908C>T	c.(907-909)aCt>aTt	p.T303I	PROKR2_ENST00000217270.3_Missense_Mutation_p.T303I			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	303						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CACGAACACAGTGGGGAAGAA	0.552000										HNSCC(71;0.22)			44	65					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127622432	127622432	+	Silent	SNP	C	C	T	rs28763928		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127622432C>T	ENST00000508053.1	-	61	7964	c.6990G>A	c.(6988-6990)agG>agA	p.R2330R	FBN2_ENST00000262464.4_Silent_p.R2330R			P35556	FBN2_HUMAN	fibrillin 2	2330	EGF-like 39; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTCCATCGGGCCTTCGGGCCA	0.512000													13	65					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91795689	91795689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91795689C>T	ENST00000394232.1	+	4	1193	c.723C>T	c.(721-723)atC>atT	p.I241I	SV2B_ENST00000545111.2_Silent_p.I90I|SV2B_ENST00000330276.4_Silent_p.I241I	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	241					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GGCTGGGCATCTTCTGGATGA	0.532000													29	76					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71408680	71408680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71408680G>A	ENST00000302628.4	+	3	281	c.204G>A	c.(202-204)atG>atA	p.M68I	CALB2_ENST00000349553.5_Missense_Mutation_p.M68I	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	68	EF-hand 2.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				GAGAAAAGATGAAGGAGTTCA	0.478000													16	50					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197889254	197889254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197889254C>T	ENST00000367390.3	+	3	327	c.300C>T	c.(298-300)ctC>ctT	p.L100L	LHX9_ENST00000367391.1_Silent_p.L100L|LHX9_ENST00000367387.4_Silent_p.L109L|LHX9_ENST00000337020.2_Silent_p.L109L|LHX9_ENST00000561173.1_Silent_p.L115L	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	109	LIM zinc-binding 1.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						AGTCCGAGCTCACCTGCTTTG	0.557000													21	328					0	0	1	0	0
TRGV8	6982	broad.mit.edu	37	7	38370174	38370174	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38370174C>T	ENST00000390343.2	-	0	237																											ACAGGAAGATCACAAGTGATT	0.502000													35	67					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76427474	76427474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76427474G>A	ENST00000357063.3	+	29	6027	c.4767G>A	c.(4765-4767)ccG>ccA	p.P1589P	LMO7_ENST00000377534.3_Silent_p.P1589P|LMO7_ENST00000321797.8_Silent_p.P1304P|LMO7_ENST00000526202.1_Silent_p.P1181P|LMO7_ENST00000341547.4_Silent_p.P1255P|LMO7_ENST00000465261.2_Silent_p.P1304P			Q8WWI1	LMO7_HUMAN	LIM domain 7	1589						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		CCCCCACCCCGAGAAGCCATT	0.577000													17	72					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147131157	147131157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:147131157C>T	ENST00000282928.4	+	3	1892	c.1163C>T	c.(1162-1164)tCg>tTg	p.S388L		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	388	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						GAATCCTCCTCGCAGGGCTCG	0.627000													29	88					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240286601	240286601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240286601G>A	ENST00000319653.9	+	2	1968	c.1738G>A	c.(1738-1740)Gaa>Aaa	p.E580K		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	580					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTGCTTCAGGGAACCGTGTAA	0.493000													30	77					0	0	1	0	0
LDLRAD2	401944	broad.mit.edu	37	1	22140991	22140991	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22140991C>T	ENST00000344642.2	+	2	373	c.186C>T	c.(184-186)acC>acT	p.T62T	LDLRAD2_ENST00000543870.1_Silent_p.T62T	NM_001013693.2	NP_001013715.2	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain containing 2	62						integral to membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)	6		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		CTCCGGACACCGACTGCGGGC	0.726000													8	47					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	94797	94797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:94797C>T	ENST00000309812.4	-	2	175	c.113G>A	c.(112-114)gGg>gAg	p.G38E	TUBB8_ENST00000332708.5_Intron|TUBB8_ENST00000447903.2_5'UTR|TUBB8_ENST00000413237.3_5'UTR	NM_177987.2	NP_817124.1	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	38					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GTGGCTGTCCCCGTGGTAGGT	0.647000													5	8					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101765653	101765653	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101765653C>T	ENST00000334289.3	-	8	1399	c.804G>A	c.(802-804)acG>acA	p.T268T		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	268	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		TAAAAAATCTCGTTTCATCCT	0.313000													20	55					0	0	1	0	0
CHST1	8534	broad.mit.edu	37	11	45671761	45671761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:45671761C>T	ENST00000308064.2	-	4	1383	c.713G>A	c.(712-714)gGc>gAc	p.G238D		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	238					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		AGCCAGAATGCCGCGGGGGTC	0.652000													16	60					0	0	1	0	0
SNTB1	6641	broad.mit.edu	37	8	121823712	121823712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121823712C>T	ENST00000395601.3	-	2	786	c.372G>A	c.(370-372)ggG>ggA	p.G124G	SNTB1_ENST00000519177.1_5'UTR|SNTB1_ENST00000517992.1_Silent_p.G124G	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	124	PDZ.|PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGATGCTGATCCCCAGCCCGC	0.637000													15	31					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810601	123810601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123810601C>T	ENST00000307033.2	+	1	352	c.278C>T	c.(277-279)tCc>tTc	p.S93F		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCTACCATTTCCTTTGGTGGA	0.468000													29	93					0	0	1	0	0
KRT28	162605	broad.mit.edu	37	17	38953243	38953243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38953243G>A	ENST00000306658.7	-	5	968	c.903C>T	c.(901-903)ttC>ttT	p.F301F		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	301	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				GGCTCCGGGCGAAAGTGGCTG	0.657000													22	50					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124345586	124345586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124345586C>T	ENST00000338354.3	+	16	1576	c.1470C>T	c.(1468-1470)tcC>tcT	p.S490S	DMBT1_ENST00000344338.3_Silent_p.S480S|DMBT1_ENST00000368955.3_Silent_p.S480S|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368909.3_Silent_p.S490S			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	490					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GATCTGAATCCAGTTTGGCCC	0.542000													119	312					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	92006331	92006331	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:92006331C>T	ENST00000450295.1	-	9	1399		c.e9-1		SEMA4D_ENST00000455551.2_Splice_Site|SEMA4D_ENST00000343780.4_Splice_Site|SEMA4D_ENST00000438547.2_Splice_Site|SEMA4D_ENST00000420987.1_Splice_Site|SEMA4D_ENST00000339861.4_Splice_Site|SEMA4D_ENST00000356444.2_Splice_Site|SEMA4D_ENST00000422704.2_Splice_Site			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D						anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						AAACTAGGCTCTGCAGAGAGA	0.582000													13	57					0	0	1	0	0
HOXA5	3202	broad.mit.edu	37	7	27182802	27182802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27182802C>T	ENST00000222726.3	-	1	485	c.425G>A	c.(424-426)gGg>gAg	p.G142E	HOXA3_ENST00000467897.2_Intron|HOXA-AS3_ENST00000521197.1_RNA|HOXA-AS3_ENST00000518848.1_RNA	NM_019102.3	NP_061975.2	P20719	HXA5_HUMAN	homeobox A5	142					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(12)|skin(1)	16						CGTGCCAACCCCCTCTCTGCT	0.736000													24	60					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166870271	166870271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166870271G>A	ENST00000423058.2	-	18	3705	c.3688C>T	c.(3688-3690)Ctt>Ttt	p.L1230F	SCN1A_ENST00000409050.1_Missense_Mutation_p.L1202F|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.L1219F|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.L1230F	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1230						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCACTACTAAGGAGAATCATG	0.378000													25	66					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409824	56409824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56409824C>T	ENST00000544374.1	-	1	123	c.95G>A	c.(94-96)gGa>gAa	p.G32E	OR5AP2_ENST00000302981.1_Missense_Mutation_p.G31E			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						AAAGAGGACTCCTTGTAGATC	0.413000													9	95					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124988179	124988179	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124988179G>A	ENST00000522917.1	+	9	931	c.725G>A	c.(724-726)tGg>tAg	p.W242*	FER1L6_ENST00000399018.1_Nonsense_Mutation_p.W242*	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	242	C2 2.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAGAGACCGTGGGCCAGATTC	0.443000													65	121					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34111984	34111984	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34111984C>T	ENST00000389232.4	+	77	10804	c.10734C>T	c.(10732-10734)acC>acT	p.T3578T	RYR3_ENST00000415757.3_Silent_p.T3573T	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3578					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTTTGTACACCTCCTATTCCA	0.353000													135	331					0	0	1	0	0
NR2E3	10002	broad.mit.edu	37	15	72104690	72104690	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72104690G>A	ENST00000398840.2	+	0	776							Q9Y5X4	NR2E3_HUMAN	nuclear receptor subfamily 2, group E, member 3						phototransduction|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|endometrium(1)|lung(1)	3						TGAGAATATTGATGTCACCAG	0.582000													46	138					0	0	1	0	0
HOXB13	10481	broad.mit.edu	37	17	46805705	46805705	+	Missense_Mutation	SNP	C	C	T	rs138213197	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46805705C>T	ENST00000290295.7	-	1	835	c.251G>A	c.(250-252)gGa>gAa	p.G84E		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	84					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GTACCCGCCTCCAAAGTAACC	0.687000													12	70					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13741672	13741672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:13741672C>T	ENST00000383314.2	+	7	1196	c.956C>T	c.(955-957)cCc>cTc	p.P319L	RNMT_ENST00000589866.1_Missense_Mutation_p.P319L|RNMT_ENST00000592764.1_Missense_Mutation_p.P319L|RNMT_ENST00000543302.2_Missense_Mutation_p.P319L|RNMT_ENST00000535051.1_Missense_Mutation_p.P77L|RNMT_ENST00000262173.3_Missense_Mutation_p.P319L			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	319					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						GGTACTACTCCCAATAGCTTT	0.343000													17	89					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602378	138602378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138602378G>A	ENST00000440172.1	-	2	2042	c.1994C>T	c.(1993-1995)cCc>cTc	p.P665L	KIAA1549_ENST00000422774.1_Missense_Mutation_p.P665L|KIAA1549_ENST00000242365.4_Missense_Mutation_p.P615L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	665	Ser-rich.					integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CTCAACCAAGGGAGAAAAAGA	0.502000			O	BRAF	pilocytic astrocytoma								3	27					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11008349	11008349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11008349C>T	ENST00000377004.4	-	12	1842	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K	C1orf127_ENST00000377008.4_Missense_Mutation_p.E448K	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	466										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GAGCACGTTTCCTGGGGCTCT	0.662000													38	96					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103566796	103566796	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103566796C>T	ENST00000380069.3	+	1	316	c.240C>T	c.(238-240)tcC>tcT	p.S80S		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	80										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						GGCGAAGCTCCTGCTCCCTGT	0.672000													13	25					0	0	1	0	0
RGR	5995	broad.mit.edu	37	10	86008723	86008723	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:86008723G>A	ENST00000372092.3	+	3	249	c.244G>A	c.(244-246)Ggg>Agg	p.G82R	RGR_ENST00000359452.4_Silent_p.Q98Q|RGR_ENST00000358110.5_Silent_p.Q94Q			P47804	RGR_HUMAN	retinal G protein coupled receptor	0					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	17						ACGGCTTCCAGGGCTTTGTGA	0.632000													10	56					0	0	1	0	0
C14orf166	51637	broad.mit.edu	37	14	52458057	52458057	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52458057C>T	ENST00000261700.3	+	2	249	c.84C>T	c.(82-84)ttC>ttT	p.F28F	C14orf166_ENST00000556760.1_Silent_p.F28F	NM_016039.2	NP_057123.1	Q9Y224	CN166_HUMAN	chromosome 14 open reading frame 166	28						microtubule organizing center|nucleus|perinuclear region of cytoplasm|tRNA-splicing ligase complex	identical protein binding			endometrium(1)|large_intestine(3)|lung(2)	6	Breast(41;0.0639)|all_epithelial(31;0.101)					TTAGAAACTTCATCGTTTGGC	0.353000													5	61					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211541795	211541795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211541795C>T	ENST00000233072.5	+	37	4535	c.4339C>T	c.(4339-4341)Cat>Tat	p.H1447Y	CPS1_ENST00000430249.2_Missense_Mutation_p.H1453Y|CPS1_ENST00000451903.2_Missense_Mutation_p.H996Y	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1447					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity	p.H1447D(1)|p.H1453D(1)		breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TAAATTTGTCCATGATAATTA	0.378000													37	148					0	0	1	0	0
REEP4	80346	broad.mit.edu	37	8	21996484	21996484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:21996484G>A	ENST00000306306.3	-	6	976	c.508C>T	c.(508-510)Ccc>Tcc	p.P170S	REEP4_ENST00000334530.5_Intron|REEP4_ENST00000523293.1_Missense_Mutation_p.P170S	NM_025232.2	NP_079508.2	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	170						integral to membrane				kidney(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	7				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		AGGTAGAGGGGGTCATGGTAG	0.677000													8	21					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157959834	157959834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157959834C>T	ENST00000389413.3	-	6	802	c.699G>A	c.(697-699)gtG>gtA	p.V233V	PTPRN2_ENST00000409483.1_Silent_p.V195V|PTPRN2_ENST00000404321.2_Silent_p.V256V|PTPRN2_ENST00000389416.4_Silent_p.V216V|PTPRN2_ENST00000389418.4_Silent_p.V233V	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	233						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CACCACTGTCCACCTTAGGGC	0.697000													18	36					0	0	1	0	0
WFDC3	140686	broad.mit.edu	37	20	44405749	44405749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44405749C>T	ENST00000243938.4	-	5	541	c.458G>A	c.(457-459)gGc>gAc	p.G153D	WFDC3_ENST00000481847.1_Intron|WFDC3_ENST00000372630.2_Intron|WFDC3_ENST00000372632.2_Intron	NM_080614.1	NP_542181.1	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3	153	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity			endometrium(1)|large_intestine(3)|prostate(1)	5		Myeloproliferative disorder(115;0.0122)				GCGGCCACAGCCGGTGCTGCA	0.557000													19	33					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37323488	37323488	+	Missense_Mutation	SNP	C	C	T	rs140013994		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37323488C>T	ENST00000361924.2	+	3	576	c.202C>T	c.(202-204)Cgg>Tgg	p.R68W	GOLGA4_ENST00000444882.1_Missense_Mutation_p.R68W|GOLGA4_ENST00000356847.4_Missense_Mutation_p.R90W|GOLGA4_ENST00000435830.2_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	68					Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GCTCCAGCTCCGGGTGCCCTC	0.443000													14	117					0	0	1	0	0
TSPAN13	27075	broad.mit.edu	37	7	16817503	16817503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:16817503C>T	ENST00000262067.4	+	4	826	c.393C>T	c.(391-393)ttC>ttT	p.F131F	TSPAN13_ENST00000466195.1_3'UTR	NM_014399.3	NP_055214.1	O95857	TSN13_HUMAN	tetraspanin 13	131						integral to plasma membrane|membrane fraction				autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)|skin(1)|stomach(1)	7	Lung NSC(10;0.0494)|all_lung(11;0.109)			UCEC - Uterine corpus endometrioid carcinoma (126;0.188)		GCTGTGGGTTCCGAAGTGTTA	0.368000													13	71					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38798333	38798333	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38798333C>T	ENST00000449082.2	-	9	1121	c.1122G>A	c.(1120-1122)atG>atA	p.M374I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	374					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAAAAAAGATCATATAGATTT	0.473000													36	89					0	0	1	0	0
ERMARD	55780	broad.mit.edu	37	6	170154030	170154030	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:170154030T>A	ENST00000366773.3	+	2	110	c.77T>A	c.(76-78)tTt>tAt	p.F26Y	C6orf70_ENST00000366772.2_Missense_Mutation_p.F26Y|C6orf70_ENST00000588451.1_5'UTR|C6orf70_ENST00000392095.4_Intron|C6orf70_ENST00000418781.3_Missense_Mutation_p.F26Y	NM_001278532.1|NM_018341.1	NP_001265461.1|NP_060811.1	Q5T6L9	CF070_HUMAN		26						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		AATCTTGGGTTTCAACTCAGA	0.353000													10	20					0	0	1	0	0
MS4A3	932	broad.mit.edu	37	11	59829943	59829943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59829943C>T	ENST00000278865.3	+	3	232	c.159C>T	c.(157-159)gcC>gcT	p.A53A	MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000534744.1_Intron|MS4A3_ENST00000358152.2_Intron	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	53						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				TCTTTCAGGCCATCCAGATCC	0.433000													36	88					0	0	1	0	0
WDR93	56964	broad.mit.edu	37	15	90286605	90286605	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90286605G>C	ENST00000268130.7	+	17	2145	c.2044G>C	c.(2044-2046)Gag>Cag	p.E682Q	WDR93_ENST00000560294.1_Missense_Mutation_p.E654Q|WDR93_ENST00000444934.2_Missense_Mutation_p.E399Q	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	682					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			GCTCCAGAGAGAGAACTTCAA	0.577000													15	81					0	0	1	0	0
RP3-400B16.4	0	broad.mit.edu	37	6	4135832	4135832	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:4135832G>A	ENST00000527831.1	+	0	123																											GCTCGGGGGTGGGGCCGGGTC	0.751000													5	15					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072087	9072087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9072087G>A	ENST00000397910.4	-	3	15562	c.15359C>T	c.(15358-15360)tCt>tTt	p.S5120F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5122	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGTTTATAGAAGGAAAAAT	0.443000													28	69					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72952047	72952047	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72952047G>A	ENST00000425042.2	-	13	1553	c.1476C>T	c.(1474-1476)tcC>tcT	p.S492S		NM_030630.2	NP_085133.1			HID1 domain containing																		TGAGGTAGGGGGACACTGTAA	0.617000													7	102					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356729	42356729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:42356729G>A	ENST00000554171.1	+	5	3333	c.901G>A	c.(901-903)Gga>Aga	p.G301R	LRFN5_ENST00000554120.1_Missense_Mutation_p.G301R|LRFN5_ENST00000298119.4_Missense_Mutation_p.G301R			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	301	Ig-like.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AGTCCTGGAGGGACAAAGGGC	0.468000										HNSCC(30;0.082)			41	97					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151911	158151911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158151911G>A	ENST00000368171.3	+	4	917	c.418G>A	c.(418-420)Gat>Aat	p.D140N		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	140					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TCAAGGAAAAGATATCCTGAG	0.522000													15	278					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32712801	32712801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:32712801C>T	ENST00000421745.2	+	41	8035	c.7901C>T	c.(7900-7902)tCa>tTa	p.S2634L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2634					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					ATACAGTTATCATCTGTCCCA	0.368000													44	88					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7374329	7374329	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7374329C>T	ENST00000502583.1	-	5	1287	c.723G>A	c.(721-723)ggG>ggA	p.G241G	CAGE1_ENST00000338150.4_Silent_p.G241G|CAGE1_ENST00000379918.4_Silent_p.G241G|CAGE1_ENST00000296742.7_Silent_p.G105G|CAGE1_ENST00000512086.1_Silent_p.G241G|CAGE1_ENST00000509324.1_5'UTR	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	241										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					CAGGAATCTCCCCATAATTCT	0.398000													33	125					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121356074	121356074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121356074C>T	ENST00000314583.3	-	7	575	c.484G>A	c.(484-486)Ggg>Agg	p.G162R	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Intron	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	162					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		TTCTCCACCCCGTACCGGCCA	0.557000													32	100					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15296162	15296162	+	Silent	SNP	G	G	A	rs140040122	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15296162G>A	ENST00000263388.2	-	14	2277	c.2202C>T	c.(2200-2202)gcC>gcT	p.A734A		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	734	EGF-like 19.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.A734A(1)		breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AGGCGTCTCGGGCCAGGCTCT	0.682000													8	20					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183777626	183777626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183777626C>T	ENST00000318351.1	+	8	970	c.936C>T	c.(934-936)ttC>ttT	p.F312F		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	312						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GTGTCTACTTCGCCCTGTGCC	0.517000													9	114					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32955366	32955366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32955366G>A	ENST00000340811.4	-	10	2246	c.2138C>T	c.(2137-2139)tCc>tTc	p.S713F	PKP2_ENST00000070846.6_Missense_Mutation_p.S757F	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	757					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AAGATTCCGGGACAGATTCCT	0.443000													80	173					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074935	106074935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106074935G>A	ENST00000278071.2	-	3	1327	c.875C>T	c.(874-876)tCc>tTc	p.S292F	ITPRIP_ENST00000358187.2_Missense_Mutation_p.S292F|ITPRIP_ENST00000337478.1_Missense_Mutation_p.S292F	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	292						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						CAGGTACAGGGAATCTGTGGC	0.597000													17	48					0	0	1	0	0
ZNF701	55762	broad.mit.edu	37	19	53086249	53086249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53086249C>T	ENST00000540331.1	+	5	1360	c.1135C>T	c.(1135-1137)Ctt>Ttt	p.L379F	CTD-3099C6.7_ENST00000599222.1_RNA|ZNF701_ENST00000391785.3_Missense_Mutation_p.L313F|ZNF701_ENST00000301093.2_Missense_Mutation_p.L379F	NM_001172655.1	NP_001166126.1	Q9NV72	ZN701_HUMAN	zinc finger protein 701	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(6)	14				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		ACAATCAAACCTTGCACGTCA	0.388000													36	92					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19822199	19822199	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19822199G>A	ENST00000344099.3	-	4	2029	c.1891C>T	c.(1891-1893)Cga>Tga	p.R631*		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				TCATGCAGTCGAAAGTGACTG	0.393000													14	127					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50600952	50600952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:50600952G>A	ENST00000216373.5	-	19	3238	c.2964C>T	c.(2962-2964)ttC>ttT	p.F988F	SOS2_ENST00000543680.1_Silent_p.F955F	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	988	Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					GGTTTTCAAAGAATCTCTGGA	0.289000													68	173					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383934	108383934	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108383934T>A	ENST00000265843.4	-	6	2410	c.2300A>T	c.(2299-2301)aAa>aTa	p.K767I	EXPH5_ENST00000428840.1_Missense_Mutation_p.K691I|EXPH5_ENST00000443411.1_Missense_Mutation_p.K579I|EXPH5_ENST00000525344.1_Missense_Mutation_p.K760I	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	767					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GGGTGACTTTTTTGAACTTAT	0.378000													64	144					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65517349	65517349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:65517349C>T	ENST00000310193.3	-	5	1296	c.1123G>A	c.(1123-1125)Gat>Aat	p.D375N	CYP7B1_ENST00000523954.1_5'UTR	NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	375					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AGAGTCAAATCCTCCTCAACA	0.428000													18	51					0	0	1	0	0
AIFM3	150209	broad.mit.edu	37	22	21328398	21328398	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21328398C>T	ENST00000399167.2	+	5	642	c.402C>T	c.(400-402)tgC>tgT	p.C134C	AIFM3_ENST00000405089.1_Silent_p.C140C|AIFM3_ENST00000399163.2_Silent_p.C134C|AIFM3_ENST00000440238.2_Silent_p.C134C|AIFM3_ENST00000335375.5_Silent_p.C122C|AIFM3_ENST00000333607.6_Silent_p.C134C	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			ACGGCGCCTGCTTCAACATCA	0.662000													10	21					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814637	242814637	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242814637C>T	ENST00000343216.3	+	2	958	c.930C>T	c.(928-930)tcC>tcT	p.S310S		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	310						integral to membrane											GCCCCATCTCCCTCAACAATG	0.662000													25	61					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76919504	76919504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76919504C>T	ENST00000409709.3	+	43	6158	c.5886C>T	c.(5884-5886)ttC>ttT	p.F1962F	MYO7A_ENST00000409619.2_Silent_p.F1913F|MYO7A_ENST00000458637.2_Silent_p.F1924F|MYO7A_ENST00000605744.1_3'UTR	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1962	FERM 2.		Missing (in USH1B).		actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ATGACTTCTTCTTTGACTTTG	0.527000													3	13					0	0	1	0	0
GHDC	84514	broad.mit.edu	37	17	40344693	40344693	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40344693G>T	ENST00000301671.8	-	4	896	c.455C>A	c.(454-456)gCc>gAc	p.A152D	GHDC_ENST00000587427.1_Missense_Mutation_p.A152D|GHDC_ENST00000428494.2_Missense_Mutation_p.A113D|GHDC_ENST00000414034.3_Missense_Mutation_p.A152D|GHDC_ENST00000593209.1_Missense_Mutation_p.A152D|GHDC_ENST00000436923.2_Missense_Mutation_p.A152D			Q8N2G8	GHDC_HUMAN	GH3 domain containing	152						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CGTCACACGGGCAGTGCGTCC	0.637000													20	36					1.37878e-21	1.38734e-21	1	1	0
ABCB4	5244	broad.mit.edu	37	7	87092091	87092091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87092091C>T	ENST00000265723.4	-	4	380	c.269G>A	c.(268-270)gGa>gAa	p.G90E	ABCB4_ENST00000359206.3_Missense_Mutation_p.G90E|ABCB4_ENST00000545634.1_Missense_Mutation_p.G90E|ABCB4_ENST00000358400.3_Missense_Mutation_p.G90E|ABCB4_ENST00000453593.1_Missense_Mutation_p.G90E	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	90	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GGAGAAGTTTCCTGCAGTATC	0.388000													16	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569978	179569978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179569978C>T	ENST00000589042.1	-	103	29751	c.29527G>A	c.(29527-29529)Gga>Aga	p.G9843R	TTN_ENST00000342992.6_Missense_Mutation_p.G8599R|TTN_ENST00000591111.1_Missense_Mutation_p.G9526R|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9526	Ig-like 79.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGTGATTCCATACATGCGG	0.378000													18	60					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35756549	35756549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:35756549C>T	ENST00000400445.3	+	29	5249	c.4715C>T	c.(4714-4716)tCg>tTg	p.S1572L	NBEA_ENST00000310336.4_Missense_Mutation_p.S1572L|NBEA_ENST00000540320.1_Missense_Mutation_p.S1572L|NBEA_ENST00000379939.2_Missense_Mutation_p.S1569L	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	1572						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TACTTCATTTCGGTTCTGATG	0.373000													29	98					0	0	1	0	0
MT1JP	4498	broad.mit.edu	37	16	56670357	56670357	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56670357C>T	ENST00000564564.1	+	0	683																											GCAGGTGGCTCCTGCACGTGC	0.572000													10	70					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325912	57325912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57325912G>A	ENST00000326441.9	-	10	4261	c.3898C>T	c.(3898-3900)Cac>Tac	p.H1300Y	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.H1176Y|PEG3_ENST00000593695.1_Missense_Mutation_p.H1174Y|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.H1300Y	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1300					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACAGTTACGTGATCTGCAAGT	0.458000													21	69					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88853988	88853988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88853988G>A	ENST00000537554.1	-	2	4568	c.1006C>T	c.(1006-1008)Cgc>Tgc	p.R336C	CNR1_ENST00000549890.1_Missense_Mutation_p.R336C|CNR1_ENST00000535130.1_Missense_Mutation_p.R336C|CNR1_ENST00000369499.2_Missense_Mutation_p.R336C|CNR1_ENST00000369501.2_Missense_Mutation_p.R336C|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000428600.2_Missense_Mutation_p.R336C|CNR1_ENST00000549716.1_Missense_Mutation_p.R275C|CNR1_ENST00000468898.1_Missense_Mutation_p.R303C	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	336					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	ATGTCCATGCGGGCTTGGTCT	0.567000													44	67					0	0	1	0	0
MAN1C1	57134	broad.mit.edu	37	1	26090428	26090428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26090428C>T	ENST00000374332.4	+	7	1441	c.1111C>T	c.(1111-1113)Ctc>Ttc	p.L371F	MAN1C1_ENST00000263979.3_Missense_Mutation_p.L191F|MAN1C1_ENST00000374329.1_Missense_Mutation_p.L142F	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	371					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		CCCCAACTTCCTCAGCCCAGT	0.582000													31	91					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24884069	24884069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24884069G>A	ENST00000396432.2	-	20	4249	c.3763C>T	c.(3763-3765)Cgt>Tgt	p.R1255C	ARHGAP21_ENST00000320481.6_Missense_Mutation_p.R1042C	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1254	Rho-GAP.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GTTTTCAGACGATCTAGAGGA	0.303000													19	49					0	0	1	0	0
TMEM133	83935	broad.mit.edu	37	11	100863137	100863137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100863137C>T	ENST00000303130.2	+	1	327	c.98C>T	c.(97-99)cCc>cTc	p.P33L		NM_032021.2	NP_114410.1	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	33						integral to membrane				kidney(2)|large_intestine(1)|lung(1)|prostate(1)	5		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		GTTACTTTCCCCTTGACTAAA	0.423000													32	99					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118960710	118960710	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118960710G>A	ENST00000334549.1	+	2	264	c.264G>A	c.(262-264)caG>caA	p.Q88Q		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	88						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		GGCATCTGCAGAAGGTGAAGC	0.517000													66	166					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48772186	48772186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:48772186G>A	ENST00000314191.2	-	47	6246	c.6190C>T	c.(6190-6192)Cgt>Tgt	p.R2064C	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.R2064C	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2065					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CTCCGAAAACGACCAGTGGCA	0.458000								Non-homologous end-joining					54	166					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120474738	120474738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:120474738G>A	ENST00000355622.6	+	3	433	c.332G>A	c.(331-333)gGa>gAa	p.G111E	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.G71E	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	111					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						ATATTGACAGGAAACCCCATC	0.433000													18	48					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77376999	77376999	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77376999G>A	ENST00000451710.3	-	26	4825	c.4588C>T	c.(4588-4590)Ctc>Ttc	p.L1530F	TRPM6_ENST00000376864.4_Missense_Mutation_p.L1530F|TRPM6_ENST00000361255.3_Missense_Mutation_p.L1525F|TRPM6_ENST00000360774.1_Missense_Mutation_p.L1530F|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Missense_Mutation_p.L1525F			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1530					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TATCTGCGGAGAGGATTGATC	0.433000													13	77					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52539771	52539771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52539771G>A	ENST00000321725.6	+	15	1745	c.1669G>A	c.(1669-1671)Ggc>Agc	p.G557S		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	557	FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTTGCGTGACGGCCGCCTGAT	0.637000													14	48					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166032863	166032863	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166032863G>A	ENST00000360093.3	-	3	533	c.42C>T	c.(40-42)ttC>ttT	p.F14F	SCN3A_ENST00000283254.7_Silent_p.F14F|SCN3A_ENST00000409101.3_Silent_p.F14F	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	14						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.F14F(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TAAAAAGGCGGAAGCTTTCAG	0.428000													24	124					0	0	1	0	0
ISPD	729920	broad.mit.edu	37	7	16298032	16298032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:16298032G>A	ENST00000407010.2	-	8	1101	c.1102C>T	c.(1102-1104)Cct>Tct	p.P368S	AC004741.3_ENST00000457112.1_RNA|ISPD_ENST00000399310.3_Missense_Mutation_p.P318S|AC004741.3_ENST00000438573.1_RNA	NM_001101426.3	NP_001094896.1	A4D126	ISPD_HUMAN	isoprenoid synthase domain containing	368					isoprenoid biosynthetic process		nucleotidyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)	9						ACAACAACAGGATATAAAATG	0.318000										Multiple Myeloma(15;0.18)			6	21					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170239104	170239104	+	Missense_Mutation	SNP	G	G	A	rs147911240		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:170239104G>A	ENST00000518525.1	+	11	1629	c.1165G>A	c.(1165-1167)Gac>Aac	p.D389N	GABRP_ENST00000519385.1_3'UTR|GABRP_ENST00000265294.4_Missense_Mutation_p.D389N			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	389						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAAAACCAGCGACAAGTTCAA	0.408000													42	85					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17487897	17487897	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17487897G>A	ENST00000252590.4	-	1	262	c.201C>T	c.(199-201)gcC>gcT	p.A67A		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	67						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ATAGGCCCTCGGCTCGGCGCT	0.592000													11	38					0	0	1	0	0
MMP27	64066	broad.mit.edu	37	11	102567208	102567208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102567208C>T	ENST00000260229.4	-	6	887	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	266			E -> V (in dbSNP:rs1276286).		collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		TTAGCAGGTTCCTTAGGCAGA	0.418000													27	69					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23522829	23522829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:23522829C>T	ENST00000296682.3	+	8	899	c.717C>T	c.(715-717)gcC>gcT	p.A239A		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	239					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						ACCGTTCAGCCCTCAGTCTGC	0.572000										HNSCC(3;0.000094)			11	42					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3215001	3215001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3215001G>A	ENST00000400569.3	-	2	554	c.221C>T	c.(220-222)tCg>tTg	p.S74L	MYOM1_ENST00000261606.7_Missense_Mutation_p.S74L|RP13-270P17.2_ENST00000580139.1_RNA|MYOM1_ENST00000356443.4_Missense_Mutation_p.S74L			P52179	MYOM1_HUMAN	myomesin 1	74						striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GGCGTGCTGCGAGGCCTGCTG	0.682000													13	28					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31606601	31606601	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31606601C>T	ENST00000170150.3	+	9	1023	c.828C>T	c.(826-828)gcC>gcT	p.A276A		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	276						extracellular region	lipid binding										AGGCCGGTGCCCTCAACCTGG	0.667000													16	61					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28121356	28121356	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28121356C>T	ENST00000330236.6	+	6	1482	c.1298C>T	c.(1297-1299)cCc>cTc	p.P433L	ZKSCAN8_ENST00000457389.2_Missense_Mutation_p.P433L	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		GGAGAGAGACCCTATGAATGT	0.498000													11	123					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21742392	21742392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21742392G>A	ENST00000328843.6	+	38	6297	c.6266G>A	c.(6265-6267)cGa>cAa	p.R2089Q	DNAH11_ENST00000409508.3_Missense_Mutation_p.R2082Q			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2089					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TCTCTGAAACGAGGAGATAAA	0.398000									Kartagener syndrome				9	22					0	0	1	0	0
TEX26	122046	broad.mit.edu	37	13	31531050	31531050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:31531050G>A	ENST00000380473.3	+	4	366	c.353G>A	c.(352-354)gGg>gAg	p.G118E		NM_152325.1	NP_689538.1	Q8N6G2	CM026_HUMAN	testis expressed 26	118																	CAACAAACGGGGACACTAAAG	0.388000													27	85					0	0	1	0	0
IGLV8-61	28774	broad.mit.edu	37	22	22453567	22453567	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22453567C>T	ENST00000390283.2	+	0	359																											CACGGGGGCCCAGGCAGATGA	0.488000													32	103					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481952	140481952	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140481952C>T	ENST00000231130.2	+	1	1719	c.1719C>T	c.(1717-1719)acC>acT	p.T573T		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		573	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCCCTGCACCGAGCTGGTGC	0.701000													26	92					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94847297	94847297	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94847297G>A	ENST00000448921.1	-	5	1400	c.828C>T	c.(826-828)ttC>ttT	p.F276F	SERPINA1_ENST00000393088.4_Silent_p.F276F|SERPINA1_ENST00000437397.1_Silent_p.F276F|SERPINA1_ENST00000355814.4_Silent_p.F276F|SERPINA1_ENST00000404814.4_Silent_p.F276F|SERPINA1_ENST00000393087.4_Silent_p.F276F|SERPINA1_ENST00000402629.1_Silent_p.F276F|SERPINA1_ENST00000449399.3_Silent_p.F276F|SERPINA1_ENST00000440909.1_Silent_p.F276F	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	276					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	CAGGCAGGAAGAAGATGGCGG	0.483000													38	69					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13786434	13786434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13786434C>T	ENST00000265104.4	-	52	8778	c.8674G>A	c.(8674-8676)Gaa>Aaa	p.E2892K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2892					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTAGGTGTTTCAGCATCAGCC	0.388000									Kartagener syndrome				22	44					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68424640	68424640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68424640G>A	ENST00000265404.2	+	1	195	c.113G>A	c.(112-114)gGa>gAa	p.G38E	STAP1_ENST00000396225.1_Missense_Mutation_p.G38E	NM_012108.2	NP_036240.1	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	38	PH.				cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						AAGCGGTCAGGATACCGGGTG	0.378000													48	113					0	0	1	0	0
SOHLH2	54937	broad.mit.edu	37	13	36776042	36776042	+	Silent	SNP	C	C	T	rs144247429		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36776042C>T	ENST00000379881.3	-	2	325	c.237G>A	c.(235-237)gaG>gaA	p.E79E	CCDC169-SOHLH2_ENST00000511166.1_Silent_p.E156E|SOHLH2_ENST00000317764.6_Silent_p.E79E|SOHLH2_ENST00000554962.1_Silent_p.E156E	NM_017826.2	NP_060296.2			spermatogenesis and oogenesis specific basic helix-loop-helix 2											autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		CTTCCAGCTCCTCGGCACTTA	0.393000													28	69					0	0	1	0	0
ALDH1A1	216	broad.mit.edu	37	9	75533671	75533671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:75533671C>T	ENST00000297785.3	-	8	869	c.815G>A	c.(814-816)gGa>gAa	p.G272E	ALDH1A1_ENST00000376939.1_Intron	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	272					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	AGGGCTCTTTCCTCCAAGCTC	0.463000													16	91					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156526	22156526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22156526G>A	ENST00000397126.4	-	4	1458	c.1310C>T	c.(1309-1311)tCc>tTc	p.S437F	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAGGTTTGAGGACCAGTTGAA	0.373000													34	80					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90651043	90651043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90651043G>A	ENST00000282146.4	+	2	1364	c.923G>A	c.(922-924)cGa>cAa	p.R308Q		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	308						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				GGACTCTTGCGATCACGCAGG	0.572000													38	77					0	0	1	0	0
FETUB	26998	broad.mit.edu	37	3	186362702	186362702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186362702C>T	ENST00000265029.3	+	4	688	c.587C>T	c.(586-588)tCt>tTt	p.S196F	RP11-134F2.2_ENST00000455926.1_RNA|FETUB_ENST00000450521.1_Missense_Mutation_p.S196F|FETUB_ENST00000382134.3_Missense_Mutation_p.S131F|FETUB_ENST00000539949.1_Missense_Mutation_p.S48F|FETUB_ENST00000382136.3_Missense_Mutation_p.S159F|RP11-134F2.2_ENST00000428501.1_RNA	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	196	Cystatin fetuin-B-type 2.					extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		ACCAGGGCTTCTAGCCAGGTA	0.478000													17	74					0	0	1	0	0
SYT13	57586	broad.mit.edu	37	11	45265663	45265663	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:45265663C>T	ENST00000020926.3	-	6	1332	c.1221G>A	c.(1219-1221)tgG>tgA	p.W407*		NM_001247987.1|NM_020826.2	NP_001234916.1|NP_065877.1	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	407						transport vesicle				breast(1)|large_intestine(3)|lung(16)|ovary(1)|skin(2)	23						GCATCTCCTCCCAGTGGCTGC	0.642000													6	49					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128628034	128628034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128628034G>A	ENST00000429175.2	+	2	307	c.43G>A	c.(43-45)Gac>Aac	p.D15N	FLI1_ENST00000527767.2_3'UTR|FLI1_ENST00000525560.1_5'UTR|FLI1_ENST00000344954.6_5'UTR|FLI1_ENST00000534087.1_5'UTR	NM_002017.3	NP_002008.2	Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	15					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GGTGAGCGACGACCAGTCCCT	0.602000			T	EWSR1	Ewing sarcoma								3	12					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51464871	51464871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51464871C>T	ENST00000298355.3	-	7	2621	c.1500G>A	c.(1498-1500)gtG>gtA	p.V500V	TRIM9_ENST00000338969.5_Silent_p.V496V|TRIM9_ENST00000360392.4_Silent_p.V500V	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	500	Fibronectin type-III.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					GAAGACCATCCACAGTGCACA	0.552000													20	68					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14724560	14724560	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14724560G>A	ENST00000253697.3	+	3	792	c.340G>A	c.(340-342)Gcc>Acc	p.A114T	C3orf20_ENST00000435614.1_5'UTR|C3orf20_ENST00000412910.1_5'UTR	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	114						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						CACTGGGGCAGCCAAGCGCTC	0.627000													3	19					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29840139	29840139	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:29840139G>A	ENST00000375398.2	-	8	663	c.214C>T	c.(214-216)Cga>Tga	p.R72*	SVIL_ENST00000355867.4_Nonsense_Mutation_p.R72*|SVIL_ENST00000375400.3_Nonsense_Mutation_p.R72*			O95425	SVIL_HUMAN	supervillin	72	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TATTTGGATCGAGTTTGCTTT	0.473000													34	65					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64111644	64111644	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64111644C>T	ENST00000356786.5	+	14	1675	c.1631C>T	c.(1630-1632)tCa>tTa	p.S544L	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	544					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTCGAGGCATCAGCTGAGTGT	0.632000													42	101					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74641768	74641768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:74641768C>T	ENST00000541184.1	-	8	1244	c.767G>A	c.(766-768)gGc>gAc	p.G256D	ZDHHC15_ENST00000373367.3_Missense_Mutation_p.G265D|ZDHHC15_ENST00000373361.3_3'UTR	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	265						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						CTTGATGAAGCCAAGGTTGAA	0.433000													21	28					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22191364	22191364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22191364G>A	ENST00000374695.3	-	36	4677	c.4598C>T	c.(4597-4599)cCg>cTg	p.P1533L		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1533	Laminin EGF-like 9; second part.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GTAGCCTGGCGGGCAGCGGCA	0.687000													4	22					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6711049	6711049	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6711049G>A	ENST00000245907.6	-	12	1520	c.1428C>T	c.(1426-1428)ctC>ctT	p.L476L		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	476					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CCATTCGCAGGAGGAAGTTGA	0.597000													41	187					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870120	4870120	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4870120G>A	ENST00000322101.2	-	1	394	c.319C>T	c.(319-321)Cta>Tta	p.L107L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACCATCTGTAGAAGGCAGGCT	0.542000													21	95					0	0	1	0	0
PSORS1C2	170680	broad.mit.edu	37	6	31105856	31105856	+	Missense_Mutation	SNP	G	G	A	rs144826968	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31105856G>A	ENST00000259845.4	-	2	606	c.283C>T	c.(283-285)Ccc>Tcc	p.P95S	PSORS1C1_ENST00000547221.1_Intron|PSORS1C1_ENST00000259881.9_Intron	NM_014069.2	NP_054788.2	Q9UIG4	PS1C2_HUMAN	psoriasis susceptibility 1 candidate 2	95						extracellular region				NS(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						TCAGGCCGGGGAGGTTGAGGA	0.657000													31	50					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181689418	181689418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181689418C>T	ENST00000526775.1	+	14	1993	c.1828C>T	c.(1828-1830)Ctc>Ttc	p.L610F	CACNA1E_ENST00000367570.1_Missense_Mutation_p.L610F|CACNA1E_ENST00000367567.4_Missense_Mutation_p.L217F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.L610F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.L561F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.L561F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.L610F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	610					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GCTTTTCCTCCTCTTCCTCTT	0.463000													13	28					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7621969	7621969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7621969G>A	ENST00000256861.6	-	9	1245	c.1167C>T	c.(1165-1167)gcC>gcT	p.A389A	ITIH5_ENST00000298441.6_Silent_p.A175A|ITIH5_ENST00000446830.2_Silent_p.A171A|ITIH5_ENST00000397146.2_Silent_p.A389A|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Silent_p.A389A	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	389	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TGCCACTGTGGGCCACGTACT	0.602000													8	30					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33785177	33785177	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:33785177C>T	ENST00000261326.5	+	6	1177	c.1156C>T	c.(1156-1158)Cag>Tag	p.Q386*		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	386					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	CCCTGAGGTTCAGGGCCCAAT	0.498000													55	84					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81134721	81134721	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81134721G>A	ENST00000533478.1	-	0	5441				PKD1L2_ENST00000534142.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GCGTGTGGACGAACAGCTTAG	0.577000													5	57					0	0	1	0	0
BEND5	79656	broad.mit.edu	37	1	49202013	49202013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:49202013C>T	ENST00000371833.3	-	5	1092	c.1006G>A	c.(1006-1008)Gat>Aat	p.D336N	AGBL4_ENST00000371838.1_Intron|AGBL4_ENST00000371839.1_Intron|BEND5_ENST00000476096.1_Intron	NM_024603.2	NP_078879.2	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	336	BEN.									large_intestine(5)|lung(2)|skin(1)	8						TTCAGAACATCTGTTCCCCAA	0.468000													41	133					0	0	1	0	0
OR7G3	390883	broad.mit.edu	37	19	9237432	9237432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9237432G>A	ENST00000305444.2	-	1	194	c.195C>T	c.(193-195)atC>atT	p.I65I		NM_001001958.1	NP_001001958.1	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G, member 3	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						CCAAGGACAGGATAGAGAGGA	0.547000													48	95					0	0	1	0	0
ANKRD20A5P	440482	broad.mit.edu	37	18	14184125	14184125	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14184125C>T	ENST00000581935.1	+	0	814																				lung(3)	3						AACTTTCTTTCCAAAATATTT	0.333000													25	104					0	0	1	0	0
VSIG4	11326	broad.mit.edu	37	X	65252517	65252517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:65252517G>A	ENST00000455586.2	-	3	613	c.487C>T	c.(487-489)Ctt>Ttt	p.L163F	VSIG4_ENST00000374737.4_Missense_Mutation_p.L163F|VSIG4_ENST00000412866.2_Intron	NM_001184830.1	NP_001171759.1	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	163	Ig-like 2.				complement activation, alternative pathway	integral to membrane	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TGGCATTGAAGGCTAATCCTC	0.483000													8	33					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121410779	121410779	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121410779G>A	ENST00000393667.3	-	14	7542	c.7432C>T	c.(7432-7434)Cga>Tga	p.R2478*	GOLGB1_ENST00000340645.5_Nonsense_Mutation_p.R2473*	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2473					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		ATGCGGTCTCGATCATTTTGG	0.413000													23	204					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215333	140215333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140215333C>T	ENST00000525929.1	+	1	1365	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.F455F|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1												p.F455L(2)		NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGGCGTTCGCGCAGCCCG	0.677000													33	88					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343311	248343311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248343311C>T	ENST00000359682.2	+	1	24	c.24C>T	c.(22-24)ttC>ttT	p.F8F		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATCAGACCTTCAACTCCGACT	0.423000													51	254					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444290	20444290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20444290C>T	ENST00000305051.5	+	1	688	c.613C>T	c.(613-615)Ctt>Ttt	p.L205F		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTCTGTGACCTTCCTCTAGT	0.418000													85	191					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24832666	24832666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24832666G>A	ENST00000376451.2	+	14	3776	c.3516G>A	c.(3514-3516)ggG>ggA	p.G1172G	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000376454.3_Silent_p.G1489G|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000396446.1_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1489					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						aggaaaatggggaTTCTGTAG	0.433000													12	32					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141457967	141457967	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141457967A>T	ENST00000389484.3	-	41	7622	c.6651T>A	c.(6649-6651)aaT>aaA	p.N2217K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2217					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATAACGTGGATTCTCATATG	0.338000										TSP Lung(27;0.18)			19	131					0	0	1	0	0
SLC18A2	6571	broad.mit.edu	37	10	119014811	119014811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:119014811C>T	ENST00000298472.5	+	7	867	c.724C>T	c.(724-726)Ctc>Ttc	p.L242F	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	242					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	CGGGAGTGTGCTCTATGAGTT	0.602000													12	45					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61654077	61654077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:61654077C>T	ENST00000381103.2	+	10	1248	c.763C>T	c.(763-765)Cgt>Tgt	p.R255C	KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000506857.1_Missense_Mutation_p.R229C|KIF2A_ENST00000407818.3_Missense_Mutation_p.R275C|KIF2A_ENST00000401507.3_Missense_Mutation_p.R275C	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	275	Kinesin-motor.				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding	p.R275C(1)|p.R248C(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		CCAAACATTTCGTTTTGATTA	0.323000													8	42					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7122765	7122765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7122765G>A	ENST00000341500.5	-	18	3392	c.3353C>T	c.(3352-3354)cCc>cTc	p.P1118L	INSR_ENST00000302850.5_Missense_Mutation_p.P1130L	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1130	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAGGGTAGGGGGAGGGCGGCC	0.582000													23	48					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27212761	27212761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27212761C>T	ENST00000380036.4	+	17	3185	c.2743C>T	c.(2743-2745)Cgc>Tgc	p.R915C	TEK_ENST00000519097.1_Missense_Mutation_p.R767C|TEK_ENST00000406359.4_Missense_Mutation_p.R872C	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	915	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GGACTTCCTTCGCAAGAGCCG	0.582000													7	39					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123524485	123524485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123524485G>A	ENST00000392770.2	-	1	827	c.25C>T	c.(25-27)Ccc>Tcc	p.P9S	SCN3B_ENST00000530277.1_Missense_Mutation_p.P9S|SCN3B_ENST00000299333.3_Missense_Mutation_p.P9S	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	9					axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		GAAGCCAGGGGAAACAATCTA	0.502000													51	207					0	0	1	0	0
RHOU	58480	broad.mit.edu	37	1	228879409	228879409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228879409G>A	ENST00000366691.3	+	3	1365	c.699G>A	c.(697-699)aaG>aaA	p.K233K		NM_021205.5	NP_067028.1	Q7L0Q8	RHOU_HUMAN	ras homolog family member U	233					regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	13	Breast(184;0.162)	Prostate(94;0.183)				AACAGCCAAAGAAGTCTAAAA	0.458000													31	88					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686993	68686993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:68686993G>A	ENST00000361320.4	+	2	897	c.319G>A	c.(319-321)Gga>Aga	p.G107R	CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	107						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TGCTTTTAATGGAATACGCAG	0.358000													37	153					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50497861	50497861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50497861G>A	ENST00000301149.3	+	1	260	c.28G>A	c.(28-30)Ggc>Agc	p.G10S	GPD1_ENST00000547190.1_3'UTR|GPD1_ENST00000548814.1_Missense_Mutation_p.G10S	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	10					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	CTGCATTGTAGGCTCCGGGAA	0.587000													26	95					0	0	1	0	0
SSX5	6758	broad.mit.edu	37	X	48049607	48049607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48049607C>T	ENST00000311798.1	-	7	603	c.551G>A	c.(550-552)gGa>gAa	p.G184E	SSX5_ENST00000376923.1_Missense_Mutation_p.G143E|SSX5_ENST00000347757.1_Missense_Mutation_p.G143E	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	143				Q -> P (in Ref. 1; AAC05821).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						ATTTAGTTTTCCTGAGGGGCG	0.483000													64	42					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157737198	157737198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157737198G>A	ENST00000361516.3	-	6	1033	c.985C>T	c.(985-987)Cca>Tca	p.P329S	FCRL2_ENST00000368181.4_Intron|FCRL2_ENST00000469986.1_Missense_Mutation_p.P76S|FCRL2_ENST00000392274.3_Missense_Mutation_p.P329S	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	329	Ig-like C2-type 4.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TACAAGATTGGGGGAGAGCCT	0.597000													37	89					0	0	1	0	0
OTUB2	78990	broad.mit.edu	37	14	94510998	94510998	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94510998G>A	ENST00000203664.5	+	5	579	c.370G>A	c.(370-372)Gac>Aac	p.D124N		NM_023112.3	NP_075601.1	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2	124	OTU.				cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity			kidney(1)|large_intestine(1)|lung(2)|ovary(1)	5		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		GGTGTTCAACGACCAGAGTGC	0.587000													15	45					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35255046	35255046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:35255046G>A	ENST00000360310.1	-	14	2335	c.1768C>T	c.(1768-1770)Cgt>Tgt	p.R590C	BAZ1A_ENST00000382422.2_Missense_Mutation_p.R590C|BAZ1A_ENST00000358716.4_Missense_Mutation_p.R558C	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	590					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TTGCTCAAACGAAGCTCCATA	0.418000													48	93					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130833010	130833010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130833010C>T	ENST00000357462.5	-	15	2128	c.2035G>A	c.(2035-2037)Gat>Aat	p.D679N	POTEF_ENST00000360967.5_3'UTR|POTEF_ENST00000409914.2_Missense_Mutation_p.D679N|POTEF_ENST00000361163.4_3'UTR			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	679						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						CTTTCAATATCCTCCAAATAT	0.388000													7	60					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87718078	87718078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:87718078G>A	ENST00000436978.1	+	41	6892	c.6412G>A	c.(6412-6414)Gaa>Aaa	p.E2138K	PTPN13_ENST00000511467.1_Missense_Mutation_p.E2138K|PTPN13_ENST00000427191.2_Missense_Mutation_p.E2114K|PTPN13_ENST00000316707.6_Missense_Mutation_p.E1942K|PTPN13_ENST00000411767.2_Missense_Mutation_p.E2133K	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2133						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AGTAAAAAGTGAAAGGTGAGA	0.284000													5	7					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17554814	17554814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17554814C>T	ENST00000005226.7	-	2	91	c.92G>A	c.(91-93)cGa>cAa	p.R31Q	USH1C_ENST00000318024.4_Missense_Mutation_p.R31Q|USH1C_ENST00000527720.1_5'UTR|USH1C_ENST00000527020.1_Missense_Mutation_p.R31Q	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	31					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						GTGGTACATTCGCAGCACATC	0.507000													29	75					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128873892	128873892	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128873892C>T	ENST00000375990.3	+	8	1178	c.775C>T	c.(775-777)Cag>Tag	p.Q259*	UGGT1_ENST00000259253.6_Nonsense_Mutation_p.Q283*			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	283					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TGATGAGGTTCAGGGGTTCCT	0.353000													25	69					0	0	1	0	0
AADAT	51166	broad.mit.edu	37	4	170990371	170990371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:170990371G>A	ENST00000337664.4	-	7	1007	c.731C>T	c.(730-732)cCa>cTa	p.P244L	AADAT_ENST00000353187.2_Missense_Mutation_p.P244L|AADAT_ENST00000509167.1_Missense_Mutation_p.P248L|AADAT_ENST00000515480.1_Missense_Mutation_p.P244L	NM_016228.3	NP_057312.1	Q8N5Z0	AADAT_HUMAN	aminoadipate aminotransferase	244					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|pancreas(1)|stomach(1)	11		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAGAAATGTTGGTACCCTGAA	0.388000													23	36					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55046958	55046958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55046958G>A	ENST00000335056.3	+	4	541	c.503G>A	c.(502-504)gGg>gAg	p.G168E	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		CTTGACCAGGGGATGGAGGCT	0.537000													24	49					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33135598	33135598	+	Missense_Mutation	SNP	C	C	T	rs146082418		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33135598C>T	ENST00000341947.2	-	55	4219	c.3992G>A	c.(3991-3993)cGa>cAa	p.R1331Q	COL11A2_ENST00000374714.1_Missense_Mutation_p.R1305Q|COL11A2_ENST00000361917.1_Missense_Mutation_p.R1224Q|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000395197.1_Missense_Mutation_p.R1271Q|COL11A2_ENST00000374713.1_Missense_Mutation_p.R1284Q|COL11A2_ENST00000374712.1_Missense_Mutation_p.R1250Q|COL11A2_ENST00000374708.4_Missense_Mutation_p.R1245Q|COL11A2_ENST00000357486.1_Missense_Mutation_p.R1310Q	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1331	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCCTCCTTGTCGCCCCTCGGA	0.657000													13	30					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60711204	60711204	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60711204G>A	ENST00000227880.3	-	3	1186	c.953C>T	c.(952-954)cCc>cTc	p.P318L		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	318					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						CACCATGACGGGCAAGATCTT	0.612000													6	18					0	0	1	0	0
KRTAP10-3	386682	broad.mit.edu	37	21	45978416	45978416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45978416G>A	ENST00000391620.1	-	1	227	c.183C>T	c.(181-183)gcC>gcT	p.A61A	TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198696.2	NP_941969.2	P60369	KR103_HUMAN	keratin associated protein 10-3	61	18 X 5 AA repeats of C-C-X(3).					keratin filament				kidney(1)|lung(4)|prostate(1)|skin(1)	7						TGGGCTCACAGGCCGCCTGGC	0.711000													33	75					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25416232	25416232	+	Missense_Mutation	SNP	C	C	T	rs140457030		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25416232C>T	ENST00000255324.5	+	19	2588	c.2536C>T	c.(2536-2538)Cct>Tct	p.P846S	RNF17_ENST00000381921.1_Missense_Mutation_p.P846S	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	846					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCTTGGTGCTCCTGAAATGAC	0.343000													22	64					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	123953720	123953720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123953720C>T	ENST00000360013.3	+	3	314	c.187C>T	c.(187-189)Cgc>Tgc	p.R63C	KALRN_ENST00000240874.3_Missense_Mutation_p.R63C|KALRN_ENST00000460856.1_Missense_Mutation_p.R63C	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	63	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CTTCCCTGCTCGCAGCAATCA	0.537000													7	12					0	0	1	0	0
LHX3	8022	broad.mit.edu	37	9	139089576	139089576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139089576C>T	ENST00000371746.3	-	6	922	c.804G>A	c.(802-804)ttG>ttA	p.L268L	LHX3_ENST00000371748.5_Silent_p.L263L	NM_014564.3	NP_055379.1	Q9UBR4	LHX3_HUMAN	LIM homeobox 3	263					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	8		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		CCATTTCCGCCAAGGAAGGCT	0.687000													8	23					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167666526	167666526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167666526G>A	ENST00000367854.3	+	6	996	c.665G>A	c.(664-666)gGa>gAa	p.G222E	RCSD1_ENST00000537350.1_Missense_Mutation_p.G192E	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	222										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					TCCAGTGAGGGAGCAGCGGGA	0.597000													24	40					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700041	136700041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:136700041G>A	ENST00000445907.2	+	3	957	c.429G>A	c.(427-429)atG>atA	p.M143I	AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.M143I|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.M143I|CHRM2_ENST00000402486.3_Missense_Mutation_p.M143I|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.M143I|AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.M143I	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	143					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAGGTATGATGATTGCAGCTG	0.502000													41	90					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181689353	181689353	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181689353C>T	ENST00000526775.1	+	14	1928	c.1763C>T	c.(1762-1764)tCc>tTc	p.S588F	CACNA1E_ENST00000367570.1_Missense_Mutation_p.S588F|CACNA1E_ENST00000367567.4_Missense_Mutation_p.S195F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.S588F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.S539F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.S539F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.S588F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	588					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TATTGGGCTTCCCTACGGAAT	0.473000													21	45					0	0	1	0	0
FOXN4	121643	broad.mit.edu	37	12	109717725	109717725	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109717725C>T	ENST00000299162.5	-	10	1409	c.1305G>A	c.(1303-1305)tgG>tgA	p.W435*	FOXN4_ENST00000355216.1_Nonsense_Mutation_p.W255*	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	435					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						TCATCTCCTCCCACAGGTTCC	0.557000													10	41					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47236521	47236521	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47236521C>T	ENST00000300404.2	+	6	860	c.801C>T	c.(799-801)ttC>ttT	p.F267F	B4GALNT2_ENST00000393354.2_Silent_p.F207F|B4GALNT2_ENST00000504681.1_Silent_p.F181F	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	267					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TGTTGAAGTTCATTCTTCAGC	0.532000													71	176					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811474	23811474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23811474C>T	ENST00000314520.3	+	1	1021	c.545C>T	c.(544-546)gCc>gTc	p.A182V	MKRN3_ENST00000568252.1_Intron|MKRN3_ENST00000564592.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	182						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TTCTTTGAAGCCGAGAGAGAC	0.617000													4	56					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51687149	51687149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51687149G>A	ENST00000335449.6	+	5	715	c.659G>A	c.(658-660)gGa>gAa	p.G220E	GLDN_ENST00000396399.2_Missense_Mutation_p.G96E	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	220	Collagen-like 2.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		GGTGACAAAGGAGATGTGTCC	0.582000													10	25					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8591700	8591700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8591700C>T	ENST00000338257.8	-	23	2861	c.2594G>A	c.(2593-2595)aGg>aAg	p.R865K		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	865						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GGGCAGGGGCCTCCGCGTCGC	0.672000													7	19					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156381657	156381657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156381657C>T	ENST00000274532.2	-	2	225	c.169G>A	c.(169-171)Gac>Aac	p.D57N	TIMD4_ENST00000407087.3_Missense_Mutation_p.D57N	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	57	Ig-like V-type.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGCACTGGTCTTTCCCCCAG	0.527000													31	63					0	0	1	0	0
MPZL2	10205	broad.mit.edu	37	11	118133292	118133292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118133292C>T	ENST00000278937.2	-	3	425	c.297G>A	c.(295-297)ggG>ggA	p.G99G	MPZL2_ENST00000438295.2_Silent_p.G99G	NM_005797.3	NP_005788.1	O60487	MPZL2_HUMAN	myelin protein zero-like 2	99	Ig-like V-type.				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|skin(1)	11	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		GCTCAGGATTCCCATCCCAAG	0.517000													5	59					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43109933	43109933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43109933C>T	ENST00000230419.4	+	13	2164	c.1943C>T	c.(1942-1944)tCc>tTc	p.S648F	PTK7_ENST00000481273.1_Missense_Mutation_p.S656F|PTK7_ENST00000345201.2_Missense_Mutation_p.S608F|PTK7_ENST00000349241.2_Missense_Mutation_p.S518F|PTK7_ENST00000352931.2_Intron	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	648	Ig-like C2-type 7.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CAGAATGGCTCCCTGGTGATC	0.627000													28	69					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168093495	168093495	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168093495C>T	ENST00000519560.1	-	36	4955	c.4536G>A	c.(4534-4536)gaG>gaA	p.E1512E	SLIT3_ENST00000332966.8_Silent_p.E1519E|CTC-558O2.2_ENST00000520041.1_RNA	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1512	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTAAGTGTCTCTCCACCTCTT	0.642000													6	18					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124848315	124848315	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124848315G>A	ENST00000356219.3	-	22	2993	c.2838C>T	c.(2836-2838)acC>acT	p.T946T	NCOR2_ENST00000404121.2_Silent_p.T499T|NCOR2_ENST00000405201.1_Silent_p.T946T|NCOR2_ENST00000404621.1_Silent_p.T928T|NCOR2_ENST00000429285.2_Silent_p.T928T|NCOR2_ENST00000397355.1_Silent_p.T929T	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	946					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CGCCAGTCGGGGTGAGGAGGC	0.716000													30	56					0	0	1	0	0
ZCWPW2	152098	broad.mit.edu	37	3	28476733	28476733	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:28476733C>T	ENST00000383768.2	+	4	653	c.465C>T	c.(463-465)ttC>ttT	p.F155F	ZCWPW2_ENST00000421010.1_Silent_p.F155F			Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	155	PWWP.						zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(6)|ovary(2)	17						AGGCAACATTCGTTGGACATT	0.333000													14	84					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22729233	22729233	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:22729233C>T	ENST00000511446.1	+	0	61				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AATTTGAGTCCCAACAAGCAA	0.438000													59	323					0	0	1	0	0
DHCR24	1718	broad.mit.edu	37	1	55319263	55319263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55319263G>A	ENST00000371269.3	-	8	1339	c.1241C>T	c.(1240-1242)cCg>cTg	p.P414L	DHCR24_ENST00000537443.1_Missense_Mutation_p.P198L|DHCR24_ENST00000535035.1_Missense_Mutation_p.P373L	NM_014762.3	NP_055577.1	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase	414					anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			large_intestine(2)|liver(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7						CAGGATGAACGGACACAGCCA	0.577000													10	23					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81181868	81181868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81181868G>A	ENST00000394685.3	+	10	1440	c.1021G>A	c.(1021-1023)Gag>Aag	p.E341K	KIAA1199_ENST00000356249.5_Missense_Mutation_p.E341K|KIAA1199_ENST00000220244.3_Missense_Mutation_p.E341K			Q8WUJ3	K1199_HUMAN	KIAA1199	341										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TAAAGGTGGGGAGAAAATTTC	0.428000													56	79					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133899646	133899646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133899646C>T	ENST00000220616.4	+	9	2069	c.2029C>T	c.(2029-2031)Cct>Tct	p.P677S	TG_ENST00000377869.1_Missense_Mutation_p.P677S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	677	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGGCAGCCAGCCTGCTGGCTC	0.552000													16	52					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189733	124189733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124189733C>T	ENST00000357438.2	-	1	451	c.361G>A	c.(361-363)Gac>Aac	p.D121N		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		ACATAACGGTCATATTCCATG	0.408000													24	51					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49459669	49459669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49459669C>T	ENST00000374201.3	-	2	393	c.91G>A	c.(91-93)Gag>Aag	p.E31K	FRMPD2_ENST00000407470.4_Missense_Mutation_p.E22K|FRMPD2_ENST00000305531.3_Missense_Mutation_p.E29K	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	31	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		CAGATTTCCTCCTCAGACAGA	0.577000													5	73					0	0	1	0	0
TREML1	340205	broad.mit.edu	37	6	41121799	41121799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41121799C>T	ENST00000373127.4	-	2	121	c.73G>A	c.(73-75)Gtg>Atg	p.V25M	TREML1_ENST00000437044.2_Intron|TREML1_ENST00000426005.2_Missense_Mutation_p.V25M	NM_001271807.1	NP_001258736.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	25	Ig-like V-type.				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCCTGCAGCACCTCAGGGAGG	0.612000													11	38					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167023529	167023529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167023529C>T	ENST00000392766.2	-	17	1967	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	ZBBX_ENST00000392764.1_Missense_Mutation_p.E514K|ZBBX_ENST00000455345.2_Missense_Mutation_p.E543K|ZBBX_ENST00000392767.2_Missense_Mutation_p.E543K|ZBBX_ENST00000307529.5_Missense_Mutation_p.E543K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	543						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AATTTCTCCTCAATGGGAGCT	0.353000													24	48					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50661436	50661436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:50661436C>T	ENST00000371824.1	+	5	969	c.712C>T	c.(712-714)Cac>Tac	p.H238Y	ELAVL4_ENST00000357083.4_Missense_Mutation_p.H255Y|ELAVL4_ENST00000371823.4_Missense_Mutation_p.H238Y|ELAVL4_ENST00000371821.1_Missense_Mutation_p.H243Y|ELAVL4_ENST00000448907.2_Missense_Mutation_p.H241Y|ELAVL4_ENST00000371819.1_Missense_Mutation_p.H243Y|ELAVL4_ENST00000371827.1_Missense_Mutation_p.H238Y			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	238					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						AGGTCCACTTCACCACCAGGC	0.597000													29	83					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101092443	101092443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101092443C>T	ENST00000360863.6	-	4	452	c.258G>A	c.(256-258)agG>agA	p.R86R	RGS22_ENST00000523437.1_Silent_p.R86R|RGS22_ENST00000523287.1_5'UTR	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	86				Missing (in Ref. 1; AAH92411).	negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TCTTTCCTTTCCTTACAACAT	0.338000													35	74					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73659854	73659854	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73659854C>T	ENST00000261917.3	-	1	1751	c.758G>A	c.(757-759)tGg>tAg	p.W253*		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	253	Involved in subunit assembly (By similarity).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GTGGATAATCCAAAATCCGGC	0.607000													21	87					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152768620	152768620	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152768620G>A	ENST00000367255.5	-	29	4243	c.3642C>T	c.(3640-3642)ttC>ttT	p.F1214F	SYNE1_ENST00000413186.2_Silent_p.F1214F|SYNE1_ENST00000448038.1_Silent_p.F1221F|SYNE1_ENST00000367253.4_Silent_p.F1214F|SYNE1_ENST00000367248.3_Silent_p.F1204F|SYNE1_ENST00000423061.1_Silent_p.F1221F|SYNE1_ENST00000265368.4_Silent_p.F1214F|SYNE1_ENST00000341594.5_Silent_p.F1280F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1214					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAAGAGCCTTGAAAGAGCTGG	0.453000										HNSCC(10;0.0054)			21	22					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196749920	196749920	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:196749920G>A	ENST00000296350.5	-	5	665	c.552C>T	c.(550-552)tcC>tcT	p.S184S	MFI2_ENST00000296351.4_Silent_p.S184S	NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	184	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GGCGACAGAGGGACTCAGAGT	0.617000													25	29					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63173904	63173904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:63173904G>A	ENST00000449996.3	+	9	709	c.637G>A	c.(637-639)Gaa>Aaa	p.E213K	RGS9_ENST00000443584.3_Missense_Mutation_p.E213K|RGS9_ENST00000262406.9_Missense_Mutation_p.E213K|RGS9_ENST00000577186.1_3'UTR	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	213					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						CAATCCGAATGAAGTCAAGGT	0.493000													30	67					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38568232	38568232	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38568232A>T	ENST00000399017.2	+	42	8221	c.5474A>T	c.(5473-5475)aAg>aTg	p.K1825M	TTC3_ENST00000354749.2_Missense_Mutation_p.K1825M|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000355666.1_Missense_Mutation_p.K1825M	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1825					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				GCTGATCGGAAGCAGCCTGTT	0.572000													19	30					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145537316	145537316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145537316G>A	ENST00000394434.2	-	9	980	c.814C>T	c.(814-816)Ctt>Ttt	p.L272F	LARS_ENST00000510191.1_Missense_Mutation_p.L218F|LARS_ENST00000274562.9_Missense_Mutation_p.L245F|LARS_ENST00000545646.1_Missense_Mutation_p.L226F|LARS_ENST00000511505.1_5'UTR	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	272	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TATGGCTCAAGCACCTTCAAT	0.348000													34	64					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27499923	27499923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27499923G>A	ENST00000396271.3	-	9	1150	c.1024C>T	c.(1024-1026)Cgt>Tgt	p.R342C	ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375888.1_Missense_Mutation_p.R351C|ACBD5_ENST00000375897.3_Missense_Mutation_p.R165C|ACBD5_ENST00000375901.1_Missense_Mutation_p.R233C|ACBD5_ENST00000375905.4_Missense_Mutation_p.R307C	NM_145698.3	NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	351					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding	p.R307C(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						ATATCTTCACGAAATCCAGAA	0.418000													67	169					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10348598	10348598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10348598C>T	ENST00000255381.2	-	36	5361	c.5251G>A	c.(5251-5253)Gaa>Aaa	p.E1751K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1751					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTGCGGGCTTCCTGGACGATG	0.468000													45	109					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54792418	54792418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54792418C>T	ENST00000293379.4	-	28	3167	c.2906G>A	c.(2905-2907)cGa>cAa	p.R969Q	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	969					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding	p.R969Q(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						AGGCAGGATTCGGTAGGGCAT	0.577000													12	32					0	0	1	0	0
BTN1A1	696	broad.mit.edu	37	6	26502051	26502051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26502051G>A	ENST00000244513.6	+	2	379	c.313G>A	c.(313-315)Ggg>Agg	p.G105R		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	105	Ig-like V-type 1.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						CATCGCCAAGGGGCGCGTGGC	0.667000													8	50					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75993946	75993946	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75993946G>A	ENST00000274364.6	+	33	4638	c.4341G>A	c.(4339-4341)aaG>aaA	p.K1447K	IQGAP2_ENST00000396234.3_Silent_p.K943K|CTD-2384B11.2_ENST00000507514.1_RNA|IQGAP2_ENST00000502745.1_Silent_p.K943K|IQGAP2_ENST00000379730.3_Silent_p.K949K	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1447					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CCTACATAAAGACTTGTTTAG	0.328000													15	37					0	0	1	0	0
TAP2	6891	broad.mit.edu	37	6	32798475	32798475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32798475G>A	ENST00000374897.2	-	8	1512	c.1381C>T	c.(1381-1383)Ccc>Tcc	p.P461S	TAP2_ENST00000374899.4_Missense_Mutation_p.P461S|TAP2_ENST00000452392.2_Missense_Mutation_p.P461S	NM_000544.3	NP_000535.3	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	461					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										AGAGTGGTGGGGGCAAGCGTG	0.537000													18	27					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133389993	133389993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:133389993G>A	ENST00000204726.3	-	4	977	c.419C>T	c.(418-420)tCt>tTt	p.S140F	GOLGA3_ENST00000537452.1_Missense_Mutation_p.S140F|GOLGA3_ENST00000545875.1_Missense_Mutation_p.S140F|GOLGA3_ENST00000450791.2_Missense_Mutation_p.S140F|GOLGA3_ENST00000456883.2_Missense_Mutation_p.S140F	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	140	Interaction with GOPC.	Cleavage; by caspase-3.			intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GGGCAGGGGAGAATCTGTAGA	0.512000													15	19					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23406208	23406208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23406208C>T	ENST00000216036.4	-	5	721	c.525G>A	c.(523-525)ctG>ctA	p.L175L		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	175							binding			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		GGCAGAGGACCAGTGTGTCCA	0.577000													10	49					0	0	1	0	0
LMX1B	4010	broad.mit.edu	37	9	129458122	129458122	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:129458122C>T	ENST00000355497.5	+	7	931	c.924C>T	c.(922-924)gtC>gtT	p.V308V	LMX1B_ENST00000561065.1_Silent_p.V285V|LMX1B_ENST00000425646.2_Silent_p.V274V|LMX1B_ENST00000526117.1_Silent_p.V297V|LMX1B_ENST00000373474.4_Silent_p.V297V	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	274					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						CCCCAGAGGTCCTGTCCAGCC	0.667000									Nail-Patella Syndrome				10	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179642167	179642167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179642167G>A	ENST00000589042.1	-	26	4849	c.4625C>T	c.(4624-4626)tCa>tTa	p.S1542L	RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S1542L|TTN_ENST00000360870.5_Missense_Mutation_p.S1542L|TTN_ENST00000591111.1_Missense_Mutation_p.S1542L|TTN_ENST00000342175.6_Missense_Mutation_p.S1496L|TTN_ENST00000359218.5_Missense_Mutation_p.S1496L|TTN_ENST00000460472.2_Missense_Mutation_p.S1496L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1542	Ig-like 6.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAAATCACTGAAATTGAAGA	0.383000													8	32					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33466940	33466940	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33466940G>A	ENST00000379471.2	-	15	2007	c.1920C>T	c.(1918-1920)ccC>ccT	p.P640P	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000455041.2_Silent_p.P588P			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	640					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GTGCATCCAGGGGGCCCCCCA	0.517000											OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	376					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155724215	155724215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155724215G>A	ENST00000437809.1	-	28	5704	c.5582C>T	c.(5581-5583)tCc>tTc	p.S1861F	GON4L_ENST00000368331.1_Missense_Mutation_p.S1861F|GON4L_ENST00000271883.5_Missense_Mutation_p.S1861F			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1861					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTTCAGCTTGGAATCTGGACC	0.542000													21	178					0	0	1	0	0
LOC442028	442028	broad.mit.edu	37	2	95558357	95558357	+	RNA	SNP	G	G	A	rs76554397		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95558357G>A	ENST00000568768.1	-	0	476																											ACCACCAACCGGTGAAATCCA	0.428000													12	23					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3712680	3712680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3712680G>A	ENST00000324932.7	-	28	4771	c.4351C>T	c.(4351-4353)Cct>Tct	p.P1451S	NUP98_ENST00000359171.4_Missense_Mutation_p.P1451S|NUP98_ENST00000355260.3_Missense_Mutation_p.P1451S	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1468					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity	p.P1451S(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGATACGAAGGAAGTGGGGAG	0.428000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								11	57					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575439	179575439	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179575439C>T	ENST00000589042.1	-	98	28609	c.28385G>A	c.(28384-28386)gGa>gAa	p.G9462E	TTN_ENST00000342992.6_Missense_Mutation_p.G8218E|TTN_ENST00000591111.1_Missense_Mutation_p.G9145E|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9145	Ig-like 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGAATCTCCTTTGTCTAC	0.438000													57	78					0	0	1	0	0
GGTLC1	92086	broad.mit.edu	37	20	23966723	23966723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23966723G>A	ENST00000335694.4	-	3	498	c.294C>T	c.(292-294)ttC>ttT	p.F98F	GGTLC1_ENST00000278765.4_Silent_p.F98F|GGTLC1_ENST00000286890.4_Silent_p.F98F	NM_178311.2	NP_842563.1	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	98							gamma-glutamyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15						CTGGCTGGATGAAATTGGCAG	0.612000													32	116					0	0	1	0	0
FAM149A	25854	broad.mit.edu	37	4	187093119	187093119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187093119G>A	ENST00000356371.5	+	14	2300	c.2300G>A	c.(2299-2301)aGg>aAg	p.R767K	FAM149A_ENST00000389354.5_Missense_Mutation_p.R476K|FAM149A_ENST00000227065.4_Missense_Mutation_p.R476K|FAM149A_ENST00000503432.1_Missense_Mutation_p.R476K|FAM149A_ENST00000502970.1_Missense_Mutation_p.R476K|FAM149A_ENST00000514153.1_Missense_Mutation_p.R476K			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	767										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		ACTTTCAAGAGGAGATTCCAA	0.418000													13	96					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974138	49974138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49974138C>T	ENST00000555099.1	+	1	196	c.164C>T	c.(163-165)tCc>tTc	p.S55F		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						TCACTGAGATCCCCCATGTAC	0.428000													104	152					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685759	248685759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248685759G>A	ENST00000343414.4	+	1	844	c.812G>A	c.(811-813)gGa>gAa	p.G271E		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAAAACCAGGGAAAGTTTGTT	0.438000													28	89					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241815373	241815373	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241815373C>T	ENST00000307503.3	+	8	1185	c.798C>T	c.(796-798)gtC>gtT	p.V266V		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	266					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CAATCCCCGTCATCAGCCTGT	0.617000													4	43					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80044225	80044225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80044225G>A	ENST00000306749.2	-	22	3855	c.3637C>T	c.(3637-3639)Cct>Tct	p.P1213S		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1213					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CTGAGCAGAGGGTCCTCTGGC	0.667000													7	19					0	0	1	0	0
TTC27	55622	broad.mit.edu	37	2	32891781	32891781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:32891781C>T	ENST00000317907.4	+	7	1116	c.885C>T	c.(883-885)gtC>gtT	p.V295V		NM_001193509.1|NM_017735.4	NP_001180438.1|NP_060205.3	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	295							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						AAGGGGATGTCCTTTCAAATT	0.373000													38	86					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57931719	57931719	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57931719G>A	ENST00000574161.1	+	10	1214	c.1095G>A	c.(1093-1095)aaG>aaA	p.K365K	GCOM1_ENST00000380561.2_Silent_p.K334K|GCOM1_ENST00000572390.1_Silent_p.K365K|GCOM1_ENST00000380560.2_Silent_p.K296K|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Silent_p.K365K|GCOM1_ENST00000587652.1_Silent_p.K365K|GCOM1_ENST00000396180.1_Silent_p.K334K|MYZAP_ENST00000267853.5_Silent_p.K365K|GCOM1_ENST00000380568.3_Silent_p.K365K|MYZAP_ENST00000380565.4_Silent_p.K365K	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		365					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GCCAGCAGAAGAAAGTCAAGC	0.522000													10	34					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64517912	64517912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64517912C>T	ENST00000164139.3	-	17	2511	c.2113G>A	c.(2113-2115)Gga>Aga	p.G705R	PYGM_ENST00000377432.3_Missense_Mutation_p.G617R	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	705					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	TTTTCCTCTCCCGCCTCTTCT	0.557000													16	231					0	0	1	0	0
C1orf115	79762	broad.mit.edu	37	1	220870013	220870013	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:220870013C>T	ENST00000294889.5	+	2	927	c.369C>T	c.(367-369)ttC>ttT	p.F123F		NM_024709.4	NP_078985.3	Q9H7X2	CA115_HUMAN	chromosome 1 open reading frame 115	123						integral to membrane		p.F123F(1)		large_intestine(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0273)		TGCAAGGCTTCGCTGCAGCCT	0.557000													46	116					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23517687	23517687	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23517687G>A	ENST00000397359.3	-	13	2221	c.1960_splice	c.e13-1	p.A654_splice	CDH24_ENST00000485922.1_5'UTR|CDH24_ENST00000267383.5_Splice_Site_p.A654_splice|CDH24_ENST00000554034.1_Splice_Site_p.A616_splice|CDH24_ENST00000487137.2_Splice_Site_p.A616_splice	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	654					adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GCACCACCAGGGCTGCGCGAG	0.647000													29	91					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43909390	43909390	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43909390C>T	ENST00000562955.1	+	61	8577	c.8577C>T	c.(8575-8577)ttC>ttT	p.F2859F	SZT2_ENST00000372442.1_Silent_p.F2017F	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2916						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GCTTGGCTTTCCTGCAGCAAT	0.622000													57	160					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166911222	166911222	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166911222C>T	ENST00000423058.2	-	4	545	c.528G>A	c.(526-528)agG>agA	p.R176R	SCN1A_ENST00000409050.1_Silent_p.R176R|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Silent_p.R176R|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Silent_p.R176R	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	176						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AACAGAATCCCCTTGCAATAA	0.323000													4	44					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100677281	100677281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100677281G>A	ENST00000306151.4	+	3	2648	c.2584G>A	c.(2584-2586)Gaa>Aaa	p.E862K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	862	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTTATAGTGAAGGAAGAAC	0.488000													181	478					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494140	55494140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55494140C>T	ENST00000543010.1	+	6	1217	c.1074C>T	c.(1072-1074)ggC>ggT	p.G358G	NLRP2_ENST00000339757.7_Silent_p.G336G|NLRP2_ENST00000391721.4_Silent_p.G334G|NLRP2_ENST00000427260.2_Silent_p.G335G|NLRP2_ENST00000538819.1_Silent_p.G334G|NLRP2_ENST00000263437.6_Silent_p.G355G|NLRP2_ENST00000537859.1_Silent_p.G336G|NLRP2_ENST00000448584.2_Silent_p.G358G	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	358	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGGTGGAGGGCTTCCTGGAGG	0.622000													4	35					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219256209	219256209	+	Silent	SNP	C	C	T	rs141050730		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219256209C>T	ENST00000233202.6	+	11	1495	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	SLC11A1_ENST00000539932.1_Silent_p.F267F	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	385					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGGGACAGTTCGTGATGGAGG	0.672000													4	6					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74276776	74276776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74276776C>T	ENST00000262765.5	-	10	4101	c.3922G>A	c.(3922-3924)Gaa>Aaa	p.E1308K		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1308							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						TTGGCCTTTTCCTTTTCGAGC	0.592000													28	93					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101815074	101815074	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101815074G>A	ENST00000263468.8	+	3	597	c.327G>A	c.(325-327)caG>caA	p.Q109Q		NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	109							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AAAGAAAACAGAAGTTTGAAG	0.358000													24	58					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2040308	2040308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2040308C>T	ENST00000262113.4	+	16	2104	c.1963C>T	c.(1963-1965)Ctc>Ttc	p.L655F	MYOM2_ENST00000523438.1_Missense_Mutation_p.L80F	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	655	Fibronectin type-III 3.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CGGAACCAACCTCTGGGAGCC	0.612000													11	77					0	0	1	0	0
LECT1	11061	broad.mit.edu	37	13	53286957	53286957	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:53286957C>T	ENST00000448904.2	-	5	626	c.516G>A	c.(514-516)tgG>tgA	p.W172*	LECT1_ENST00000377962.3_Nonsense_Mutation_p.W172*	NM_001011705.1|NM_007015.2	NP_001011705.1|NP_008946.1	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1	172	BRICHOS.				cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	15		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		CTACAGCCACCCAGATAAGAG	0.408000													31	78					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42185719	42185719	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:42185719G>A	ENST00000379310.3	-	39	4938	c.4870C>T	c.(4870-4872)Cag>Tag	p.Q1624*		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		GACCTCTGCTGGAATGCTCTC	0.512000													31	109					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31320253	31320253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31320253C>T	ENST00000269197.5	+	11	2885	c.2885C>T	c.(2884-2886)tCa>tTa	p.S962L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	962					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TCAGAGATATCAAAGAGAAAA	0.423000													6	11					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72085567	72085567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:72085567C>T	ENST00000555818.1	+	3	1940	c.1592C>T	c.(1591-1593)tCt>tTt	p.S531F	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.S531F|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.S531F|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.S6F	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	531					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAAAATGGATCTCCGTACAAC	0.403000													28	79					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25283504	25283504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25283504C>T	ENST00000218548.6	+	18	2847	c.2514C>T	c.(2512-2514)atC>atT	p.I838I	ATP12A_ENST00000381946.3_Silent_p.I832I	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	832					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CCCTCTAGATCCCCTCCATTG	0.592000													16	81					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072864	17072864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17072864C>T	ENST00000359963.3	-	1	836	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	193					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCGTCTAGTTCCTTGATAGCC	0.612000													27	72					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52901670	52901670	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52901670C>T	ENST00000261844.7	-	6	1593	c.1441G>A	c.(1441-1443)Gag>Aag	p.E481K	FAM214A_ENST00000546305.2_Missense_Mutation_p.E488K	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	481								p.E481K(1)									TCTTGCCGCTCCTGGAGTAAA	0.428000													12	164					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57970952	57970952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57970952G>A	ENST00000302592.6	-	1	701	c.702C>T	c.(700-702)atC>atT	p.I234I		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				CAGCTCTGATGATGCAGACAT	0.438000													20	60					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164776773	164776773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164776773C>T	ENST00000264382.3	-	12	1438	c.1376G>A	c.(1375-1377)gGa>gAa	p.G459E		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	459	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGGTGTACTTCCATCTGACTC	0.373000										HNSCC(35;0.089)			9	45					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140682678	140682678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140682678G>A	ENST00000239451.4	-	1	934	c.755C>T	c.(754-756)aCc>aTc	p.T252I		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	252					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	ACTTAAGAGGGTACCAATAAA	0.428000													17	48					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20497945	20497945	+	Missense_Mutation	SNP	G	G	A	rs148142047		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20497945G>A	ENST00000573854.1	+	14	1793	c.1679G>A	c.(1678-1680)cGa>cAa	p.R560Q	ACSM2A_ENST00000417235.2_Missense_Mutation_p.R481Q|ACSM2A_ENST00000536134.1_Missense_Mutation_p.R332Q|ACSM2A_ENST00000396104.2_Missense_Mutation_p.R560Q|ACSM2A_ENST00000219054.6_Missense_Mutation_p.R560Q|ACSM2A_ENST00000575690.1_Missense_Mutation_p.R560Q	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	560					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding	p.R560Q(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AAAATTCAACGAGCCAAGCTT	0.473000													56	180					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66433743	66433743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:66433743C>T	ENST00000383703.3	-	16	2688	c.2085G>A	c.(2083-2085)ggG>ggA	p.G695G	SLC25A26_ENST00000536651.1_Intron|LRIG1_ENST00000496559.2_5'UTR|LRIG1_ENST00000273261.3_Silent_p.G718G			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	718	Ig-like C2-type 3.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCGGAGGGTTCCCCGTGGCTT	0.607000													26	82					0	0	1	0	0
NAP1L5	266812	broad.mit.edu	37	4	89618461	89618461	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89618461C>T	ENST00000323061.5	-	1	925	c.445G>A	c.(445-447)Gag>Aag	p.E149K	HERC3_ENST00000543130.1_Intron|HERC3_ENST00000402738.1_Intron|HERC3_ENST00000264345.3_Intron	NM_153757.2	NP_715638.1	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	149	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		tccccctcctcctcgtcatcc	0.637000													34	77					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32789541	32789541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:32789541G>A	ENST00000326958.1	+	1	597	c.34G>A	c.(34-36)Gaa>Aaa	p.E12K	NPR3_ENST00000265074.8_3'UTR																							ACATTTCTCTGAAGAACCATC	0.393000													49	128					0	0	1	0	0
FAN1	22909	broad.mit.edu	37	15	31206141	31206141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:31206141C>T	ENST00000362065.4	+	5	1949	c.1658C>T	c.(1657-1659)tCg>tTg	p.S553L		NM_014967.4	NP_055782.3	Q9Y2M0	FAN1_HUMAN	FANCD2/FANCI-associated nuclease 1	553					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding	p.S553L(1)		autonomic_ganglia(2)|breast(2)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(6)|lung(8)|skin(1)	29						CTACTGTTTTCGTTGACCGAC	0.502000								Direct reversal of damage					14	73					0	0	1	0	0
INMT	11185	broad.mit.edu	37	7	30795320	30795320	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30795320C>T	ENST00000013222.5	+	3	661	c.645C>T	c.(643-645)gcC>gcT	p.A215A	INMT_ENST00000484180.1_3'UTR|INMT_ENST00000409539.1_Silent_p.A214A|INMT-FAM188B_ENST00000458257.1_Intron	NM_001199219.1|NM_006774.4	NP_001186148.1|NP_006765.4	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	215						cytoplasm	amine N-methyltransferase activity			kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|stomach(1)	23						CCTGCGTGGCCCTGGAGAAAG	0.587000													10	66					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96025959	96025959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96025959C>T	ENST00000297954.4	+	14	3522	c.3522C>T	c.(3520-3522)tcC>tcT	p.S1174S	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Silent_p.S786S|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_Silent_p.S786S|WNK2_ENST00000395477.2_Silent_p.S1174S			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1174					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						ACCGCAGGTCCACGCGTGCGC	0.687000													3	9					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33587345	33587345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33587345C>T	ENST00000170564.2	+	7	1159	c.845C>T	c.(844-846)tCa>tTa	p.S282L		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	282						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					TTGGGAATTTCAGGCCAGGTA	0.343000													10	58					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51464813	51464813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51464813C>T	ENST00000298355.3	-	7	2679	c.1558G>A	c.(1558-1560)Gga>Aga	p.G520R	TRIM9_ENST00000338969.5_Missense_Mutation_p.G516R|TRIM9_ENST00000360392.4_Missense_Mutation_p.G520R	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	520	Fibronectin type-III.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					GGGCTGACTCCTGTTTTGTTG	0.537000													10	50					0	0	1	0	0
ITPK1	3705	broad.mit.edu	37	14	93408217	93408217	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93408217G>A	ENST00000267615.6	-	11	1107	c.934C>T	c.(934-936)Ctc>Ttc	p.L312F	ITPK1_ENST00000354313.3_Intron|ITPK1_ENST00000555495.1_Missense_Mutation_p.L193F|ITPK1_ENST00000556603.2_Missense_Mutation_p.L312F			Q13572	ITPK1_HUMAN	inositol-tetrakisphosphate 1-kinase	312	ATP-grasp.				blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)	11		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		TGGTTCAGGAGGTCTGTGAAG	0.657000													6	25					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38770069	38770069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38770069G>A	ENST00000449082.2	-	15	2603	c.2604C>T	c.(2602-2604)atC>atT	p.I868I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	868					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCAAGAAAAGGATGAGGCATA	0.517000													19	46					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58125397	58125397	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58125397C>T	ENST00000257897.3	-	9	1059	c.974G>A	c.(973-975)cGa>cAa	p.R325Q	AGAP2_ENST00000547588.1_Missense_Mutation_p.R661Q	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	661	Interaction with PLCG1 (By similarity).				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding	p.R325Q(1)		breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						ATCCAAGCTTCGTTTCTCGGA	0.532000													6	59					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94983448	94983448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94983448C>T	ENST00000357742.4	+	17	2129	c.2129C>T	c.(2128-2130)cCc>cTc	p.P710L	MCTP2_ENST00000451018.3_Intron	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	710					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TATATGATCCCCTTGGCATTG	0.413000													47	351					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181341	140181341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140181341G>A	ENST00000522353.2	+	1	559	c.559G>A	c.(559-561)Gag>Aag	p.E187K	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.E187K|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAAATGATGAGGAAATTAA	0.373000													40	57					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1811607	1811607	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1811607G>A	ENST00000539485.1	-	2	362	c.129C>T	c.(127-129)atC>atT	p.I43I	ATP8B3_ENST00000526092.1_5'UTR|ATP8B3_ENST00000525591.1_5'UTR|ATP8B3_ENST00000310127.6_Silent_p.I43I			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	43					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCTCCGCGGATGCCAGCAG	0.667000													9	23					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43872552	43872552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43872552C>T	ENST00000261488.6	-	12	1953	c.1376G>A	c.(1375-1377)cGa>cAa	p.R459Q	ENOX1_ENST00000412891.1_Missense_Mutation_p.R459Q	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	459					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TTCTTCTGTTCGGAAAAGCTG	0.478000													42	110					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52567414	52567414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52567414C>T	ENST00000313234.5	-	5	898	c.801G>A	c.(799-801)ctG>ctA	p.L267L	KRT80_ENST00000394815.2_Silent_p.L267L	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	267	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		CGGCCTCCTCCAGGCTGCGAG	0.662000													28	77					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71942074	71942074	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71942074C>T	ENST00000541756.1	+	12	1542	c.612C>T	c.(610-612)ttC>ttT	p.F204F	INPPL1_ENST00000538751.1_Silent_p.F204F|INPPL1_ENST00000298229.2_Silent_p.F446F			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	446					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CATCCTGGTTCACATCGAAGG	0.587000													40	155					0	0	1	0	0
C8orf47	203111	broad.mit.edu	37	8	99101746	99101746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:99101746G>A	ENST00000318528.3	+	2	860	c.501G>A	c.(499-501)aaG>aaA	p.K167K	C8orf47_ENST00000545282.1_Intron	NM_173549.2	NP_775820.2	Q6P6B1	CH047_HUMAN	chromosome 8 open reading frame 47	167										kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(2)	13	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			CAGTAGAGAAGGACTCTCTCA	0.517000													4	48					0	0	1	0	0
DCLK2	166614	broad.mit.edu	37	4	151177266	151177266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:151177266C>T	ENST00000296550.7	+	16	2922	c.2168C>T	c.(2167-2169)cCc>cTc	p.P723L	DCLK2_ENST00000302176.8_Missense_Mutation_p.P740L|DCLK2_ENST00000506325.1_Missense_Mutation_p.P722L	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	723	Pro-rich.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					CCAGTTCCTCCCTCAGTGGAG	0.647000													4	31					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59937222	59937222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59937222G>A	ENST00000259008.2	-	3	407	c.140C>T	c.(139-141)cCc>cTc	p.P47L	BRIP1_ENST00000577598.1_Missense_Mutation_p.P47L	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	47	Helicase ATP-binding.		P -> A (in BC; early onset; loss of ATPase and helicase activities; dbSNP:rs28903098).		DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						ACTTCCTGTGGGACTCTCCAA	0.353000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					18	98					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57648289	57648289	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57648289T>A	ENST00000269834.1	-	4	578	c.193A>T	c.(193-195)Aag>Tag	p.K65*		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	65	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATGGCTCCTTTCCTTGTTCC	0.527000													38	92					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47882631	47882631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47882631G>A	ENST00000289672.2	-	34	5424	c.5374C>T	c.(5374-5376)Ctg>Ttg	p.L1792L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1792					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGGCCCGGCAGGGAAGCTTCT	0.478000													6	45					0	0	1	0	0
RBM43	375287	broad.mit.edu	37	2	152107524	152107524	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152107524G>A	ENST00000331426.5	-	4	1121	c.970C>T	c.(970-972)Ctg>Ttg	p.L324L		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	324							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		AGGTTAATCAGGACTTCAAGG	0.343000													32	91					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133942568	133942568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133942568C>T	ENST00000361069.4	+	14	2702	c.2569C>T	c.(2569-2571)Cct>Tct	p.P857S	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	857	Laminin EGF-like 8.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CGCCCTGGCCCCTCGACCCGC	0.647000													46	48					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388862	48388862	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48388862G>A	ENST00000224600.4	-	1	2129	c.2016C>T	c.(2014-2016)gcC>gcT	p.A672A		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	672	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CTGTGCGGTAGGCGCCCTGGG	0.667000													13	25					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233275579	233275579	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233275579G>A	ENST00000258229.8	-	20	3774	c.3540C>T	c.(3538-3540)ttC>ttT	p.F1180F	PCNXL2_ENST00000520463.1_5'UTR|PCNXL2_ENST00000488780.2_Silent_p.F313F	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1180						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGAGTCTTTCGAACCACATTA	0.323000													30	11					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214670	161214670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161214670C>T	ENST00000327928.4	+	1	75	c.75C>T	c.(73-75)acC>acT	p.T25T		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	25						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						TAGCAAAGACCACACCACATA	0.393000													7	14					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125397960	125397960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:125397960C>T	ENST00000521654.2	+	4	1439	c.1439C>T	c.(1438-1440)cCa>cTa	p.P480L	RNF217_ENST00000560949.1_Missense_Mutation_p.P245L|RNF217_ENST00000368414.2_Missense_Mutation_p.P42L|RNF217_ENST00000359704.2_Missense_Mutation_p.P188L|RNF217_ENST00000275184.6_Missense_Mutation_p.P124L			Q8TC41	RN217_HUMAN	ring finger protein 217	188					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		CGCTACCTCCCAGAGAGACCT	0.438000													49	88					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1650748	1650748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:1650748C>T	ENST00000324015.3	+	7	734	c.657C>T	c.(655-657)ttC>ttT	p.F219F	SERPINF2_ENST00000450523.2_Silent_p.F155F|SERPINF2_ENST00000382061.4_Silent_p.F219F	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	219					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TTCAGGAATTCCTCTCTGGGC	0.587000													10	13					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6063645	6063645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6063645C>T	ENST00000379959.3	-	4	552	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	IL2RA_ENST00000379954.1_Intron|IL2RA_ENST00000256876.6_Missense_Mutation_p.E127K	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	127	Sushi 2.				cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GGTGGAGGTTCCCTGCAGTGA	0.527000													22	63					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49633259	49633259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49633259C>T	ENST00000334186.4	+	6	941	c.592C>T	c.(592-594)Ctt>Ttt	p.L198F	PPFIA3_ENST00000602351.1_Missense_Mutation_p.L198F	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	198						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GACTCTGAACCTTCGAGAACA	0.597000													6	55					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784984	9784984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9784984C>T	ENST00000304374.2	+	1	1727	c.1331C>T	c.(1330-1332)tCc>tTc	p.S444F		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	444					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TATCAGACGTCCCCAGATGGT	0.547000													30	55					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2690852	2690852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2690852C>T	ENST00000399655.1	+	14	2257	c.1992C>T	c.(1990-1992)atC>atT	p.I664I	CACNA1C_ENST00000347598.4_Silent_p.I664I|CACNA1C_ENST00000399591.1_Silent_p.I664I|CACNA1C_ENST00000480911.1_Silent_p.I664I|CACNA1C_ENST00000344100.3_Silent_p.I664I|CACNA1C_ENST00000399597.1_Silent_p.I664I|CACNA1C_ENST00000335762.5_Silent_p.I689I|CACNA1C_ENST00000399595.1_Silent_p.I664I|CACNA1C_ENST00000399603.1_Silent_p.I664I|CACNA1C_ENST00000399617.1_Silent_p.I664I|CACNA1C_ENST00000399606.1_Silent_p.I664I|CACNA1C_ENST00000399621.1_Silent_p.I664I|CACNA1C_ENST00000399601.1_Silent_p.I664I|CACNA1C_ENST00000399638.1_Silent_p.I664I|CACNA1C_ENST00000399649.1_Silent_p.I664I|CACNA1C_ENST00000399644.1_Silent_p.I664I|CACNA1C_ENST00000399629.1_Silent_p.I664I|CACNA1C_ENST00000327702.7_Silent_p.I664I|CACNA1C_ENST00000399634.1_Silent_p.I664I|CACNA1C_ENST00000399637.1_Silent_p.I664I|CACNA1C_ENST00000406454.3_Silent_p.I664I|CACNA1C_ENST00000402845.3_Silent_p.I664I|CACNA1C_ENST00000399641.1_Silent_p.I664I	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	664					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	tcatcatcatcttctccctcc	0.537000													10	24					0	0	1	0	0
SPINK13	153218	broad.mit.edu	37	5	147661689	147661689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147661689C>T	ENST00000512953.1	+	5	662	c.131C>T	c.(130-132)cCa>cTa	p.P44L	SPINK13_ENST00000511106.1_Missense_Mutation_p.P4L|RP11-373N22.3_ENST00000501695.3_RNA|SPINK13_ENST00000398450.4_Missense_Mutation_p.P44L			Q1W4C9	ISK13_HUMAN	serine peptidase inhibitor, Kazal type 13 (putative)	44	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			breast(2)|lung(3)	5						ATGTATATCCCACTGGACCCT	0.438000													36	111					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55794837	55794837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55794837C>T	ENST00000379665.2	+	1	624	c.525C>T	c.(523-525)ttC>ttT	p.F175F		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						TTGACCATTTCATCTGTGATT	0.438000													79	276					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815501	106815501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106815501C>T	ENST00000407775.2	+	8	3441	c.3191C>T	c.(3190-3192)tCc>tTc	p.S1064F	ZFPM2_ENST00000520492.1_Missense_Mutation_p.S932F|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S795F|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S932F|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	1064					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAGAACATTTCCCAGAATCCT	0.483000													8	27					0	0	1	0	0
VAC14	55697	broad.mit.edu	37	16	70820186	70820186	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70820186A>C	ENST00000261776.5	-	2	447	c.187T>G	c.(187-189)Tct>Gct	p.S63A		NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	63					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				GGGTGCTGAGACAGGGCAAAC	0.612000													33	76					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51975425	51975425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51975425C>T	ENST00000220478.3	+	4	594	c.191C>T	c.(190-192)cCa>cTa	p.P64L	SCG3_ENST00000542355.2_5'UTR	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	64					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		GAAAACAAGCCAGGTCAGAGC	0.338000													91	216					0	0	1	0	0
IFNW1	3467	broad.mit.edu	37	9	21141378	21141378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21141378C>T	ENST00000380229.2	-	1	766	c.192G>A	c.(190-192)gaG>gaA	p.E64E		NM_002177.1	NP_002168.1	P05000	IFNW1_HUMAN	interferon, omega 1	64					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)	5				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTTTTACCATCTCCTGGGGGA	0.527000													48	77					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181732596	181732596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181732596C>T	ENST00000526775.1	+	33	4852	c.4687C>T	c.(4687-4689)Cgc>Tgc	p.R1563C	CACNA1E_ENST00000367570.1_Missense_Mutation_p.R1582C|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R1189C|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R1563C|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R1533C|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1514C|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R1582C	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1582					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCGAGCTGCCCGCCTCATAAA	0.468000													26	44					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10265056	10265056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10265056G>A	ENST00000340748.4	-	21	2119	c.1884C>T	c.(1882-1884)ttC>ttT	p.F628F	DNMT1_ENST00000540357.1_Silent_p.F628F|DNMT1_ENST00000359526.4_Silent_p.F644F			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	628					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	AGAAAGTATCGAAGATCTGGT	0.562000													36	156					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189904209	189904209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189904209C>T	ENST00000374866.3	-	51	3988	c.3714G>A	c.(3712-3714)ggG>ggA	p.G1238G		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1238					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CATCATAGTGCCCCATGATAT	0.547000													8	30					0	0	1	0	0
LHFPL4	375323	broad.mit.edu	37	3	9547825	9547825	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9547825C>T	ENST00000287585.6	-	3	754	c.469G>A	c.(469-471)Gac>Aac	p.D157N		NM_198560.2	NP_940962.1	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4	157						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(3)|skin(1)	10	Medulloblastoma(99;0.227)					CCACACATGTCCCGGATGGTC	0.632000													10	84					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209807885	209807885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209807885G>A	ENST00000391911.1	-	5	860	c.471C>T	c.(469-471)ttC>ttT	p.F157F	LAMB3_ENST00000356082.4_Silent_p.F157F|LAMB3_ENST00000367030.3_Silent_p.F157F	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	157	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGACCCGAGGGAAGGTGGAGG	0.637000													27	64					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921783	78921783	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78921783G>A	ENST00000261751.3	-	5	975	c.864C>T	c.(862-864)acC>acT	p.T288T	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	288					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CATCGAGGGAGGTGGGTGGCA	0.567000													21	74					0	0	1	0	0
SLC16A1	6566	broad.mit.edu	37	1	113460565	113460565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113460565G>A	ENST00000538576.1	-	4	1294	c.463C>T	c.(463-465)Cct>Tct	p.P155S	SLC16A1_ENST00000369626.3_Missense_Mutation_p.P155S|SLC16A1_ENST00000433570.4_Missense_Mutation_p.P155S	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	155					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	AGGAACACAGGGCTGCCTGCC	0.507000													23	71					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41516650	41516650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41516650C>T	ENST00000400454.1	-	17	3504	c.3027G>A	c.(3025-3027)aaG>aaA	p.K1009K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1009	Fibronectin type-III 2.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCAAATGTTTCTTGGGAGCCT	0.443000													14	56					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	56977725	56977725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:56977725G>A	ENST00000371250.3	-	5	1284	c.733C>T	c.(733-735)Cgc>Tgc	p.R245C	PPAP2B_ENST00000459962.1_5'UTR	NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	245					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						TCTGATACGCGAGACAGTCCC	0.572000													13	53					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31133838	31133838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31133838C>T	ENST00000349752.5	-	15	2227	c.1588G>A	c.(1588-1590)Ggc>Agc	p.G530S	GALNT14_ENST00000406653.1_Missense_Mutation_p.G510S|GALNT14_ENST00000356174.3_Missense_Mutation_p.G497S|GALNT14_ENST00000324589.5_Missense_Mutation_p.G535S|GALNT14_ENST00000420311.2_Missense_Mutation_p.G495S|GALNT14_ENST00000486564.1_5'UTR	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	530	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					ATTTCCTTGCCGTTCTCGGTG	0.537000													31	63					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98666301	98666301	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:98666301C>T	ENST00000261574.5	+	22	2392	c.2212C>T	c.(2212-2214)Cga>Tga	p.R738*	IPO5_ENST00000490680.1_Nonsense_Mutation_p.R720*|IPO5_ENST00000539640.1_Nonsense_Mutation_p.R595*	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	720					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						GAAACGTGTTCGAGTGGCAGC	0.433000													38	120					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53809900	53809900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:53809900G>A	ENST00000396328.1	-	20	3544	c.3305C>T	c.(3304-3306)tCt>tTt	p.S1102F	WDR72_ENST00000360509.5_Missense_Mutation_p.S1102F|WDR72_ENST00000559418.1_Missense_Mutation_p.S1112F|WDR72_ENST00000567224.1_5'UTR|WDR72_ENST00000557913.1_Missense_Mutation_p.S1099F	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1102										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTCCATTTAAGACACCTTGCA	0.368000													37	99					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100433464	100433464	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100433464G>A	ENST00000279907.7	-	20	4397	c.4185C>T	c.(4183-4185)gtC>gtT	p.V1395V	UHRF1BP1L_ENST00000545232.2_Silent_p.V1045V	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1395										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						TGGCTTGCGTGACACTGCGTT	0.458000													17	55					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247607363	247607363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247607363G>A	ENST00000366497.2	+	7	3368	c.2588G>A	c.(2587-2589)cGa>cAa	p.R863Q	NLRP3_ENST00000391828.3_Missense_Mutation_p.R920Q|NLRP3_ENST00000336119.3_Missense_Mutation_p.R920Q|NLRP3_ENST00000391827.2_Missense_Mutation_p.R863Q|NLRP3_ENST00000348069.2_Missense_Mutation_p.R806Q|NLRP3_ENST00000366496.2_Missense_Mutation_p.R863Q	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	920					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTTTACCTGCGAGGCAACACT	0.493000													22	62					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182363398	182363398	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182363398C>T	ENST00000397033.2	+	15	2019	c.1589C>T	c.(1588-1590)cCa>cTa	p.P530L		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	530					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GCAGAGTCTCCACCAAGATTC	0.348000													18	60					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543050	28543050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28543050C>T	ENST00000452236.2	-	3	2049	c.1432G>A	c.(1432-1434)Gat>Aat	p.D478N		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	478	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TTTCGGATATCCTCAGTTTGT	0.428000													36	79					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34773187	34773187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34773187G>A	ENST00000338074.2	+	7	876	c.715G>A	c.(715-717)Gag>Aag	p.E239K	EPB41L1_ENST00000373946.3_Missense_Mutation_p.E208K|EPB41L1_ENST00000373950.2_Missense_Mutation_p.E142K|EPB41L1_ENST00000441639.1_Missense_Mutation_p.E177K|EPB41L1_ENST00000202028.5_Missense_Mutation_p.E177K|EPB41L1_ENST00000373941.1_Missense_Mutation_p.E239K	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	239	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					CTATGTCAGCGAGCTCCGCTT	0.587000													17	46					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622451	74622451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74622451C>T	ENST00000156626.7	-	6	1534	c.1335G>A	c.(1333-1335)ctG>ctA	p.L445L		NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	445					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GGGTGCCTTCCAGGAAGTGCA	0.562000													22	55					0	0	1	0	0
SPI1	6688	broad.mit.edu	37	11	47380496	47380496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47380496G>A	ENST00000378538.3	-	4	614	c.392C>T	c.(391-393)tCa>tTa	p.S131L	SPI1_ENST00000533968.1_Missense_Mutation_p.S131L|SPI1_ENST00000533030.1_Intron|SPI1_ENST00000227163.4_Missense_Mutation_p.S132L	NM_001080547.1|NM_003120.2	NP_001074016.1|NP_003111.2	P17947	SPI1_HUMAN	spleen focus forming virus (SFFV) proviral integration oncogene	131					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of erythrocyte differentiation	nucleus	protein binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(4)|ovary(1)	8				Lung(87;0.0967)		CTCCTCATCTGAGCTGGGCTG	0.692000													5	4					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143310846	143310846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143310846C>T	ENST00000524325.1	-	13	1713	c.1538G>A	c.(1537-1539)tGa>tAa	p.*513*	TSNARE1_ENST00000307180.3_Silent_p.*514*|TSNARE1_ENST00000520166.1_Silent_p.*514*			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	0					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CGGGTAGCATCACTTTCGGAC	0.517000													16	46					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35709136	35709136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35709136C>T	ENST00000440995.2	+	19	2737	c.2737C>T	c.(2737-2739)Cct>Tct	p.P913S	SPEF2_ENST00000356031.3_Missense_Mutation_p.P918S|SPEF2_ENST00000509059.1_Missense_Mutation_p.P913S|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	918					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCCTCCTGCTCCTCCTCCTGA	0.433000													27	85					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424057	56424057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56424057C>T	ENST00000588751.1	-	5	1150	c.1126G>A	c.(1126-1128)Gtg>Atg	p.V376M	NLRP13_ENST00000342929.3_Missense_Mutation_p.V376M			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	376	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CATGGATTCACTAATGAGGCC	0.423000													45	94					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71839802	71839802	+	Missense_Mutation	SNP	C	C	T	rs138268837		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71839802C>T	ENST00000258104.3	+	39	4476	c.4199C>T	c.(4198-4200)cCc>cTc	p.P1400L	DYSF_ENST00000410041.1_Missense_Mutation_p.P1418L|DYSF_ENST00000429174.2_Missense_Mutation_p.P1400L|DYSF_ENST00000409744.1_Missense_Mutation_p.P1387L|DYSF_ENST00000410020.3_Missense_Mutation_p.P1418L|DYSF_ENST00000394120.2_Missense_Mutation_p.P1401L|DYSF_ENST00000409366.1_Missense_Mutation_p.P1401L|DYSF_ENST00000409582.3_Missense_Mutation_p.P1417L|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Missense_Mutation_p.P1431L|DYSF_ENST00000409651.1_Missense_Mutation_p.P1432L|DYSF_ENST00000409762.1_Missense_Mutation_p.P1417L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1400						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TACTGCCCCCCCATCACCGTC	0.622000													26	81					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19120895	19120895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19120895G>A	ENST00000601879.1	-	5	2404	c.2107C>T	c.(2107-2109)Ctc>Ttc	p.L703F	SUGP2_ENST00000600377.1_Missense_Mutation_p.L717F|SUGP2_ENST00000456085.2_Missense_Mutation_p.L472F|SUGP2_ENST00000452918.2_Missense_Mutation_p.L703F|SUGP2_ENST00000337018.6_Missense_Mutation_p.L703F			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	703					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GAGGATAGGAGGGTCTGGGTC	0.642000													33	104					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43439821	43439821	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43439821G>A	ENST00000446844.3	-	0	254				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GCAAATTGTGGACAAGTAGAA	0.453000													105	204					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128324337	128324337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128324337G>A	ENST00000262462.4	+	3	1740	c.730G>A	c.(730-732)Ggt>Agt	p.G244S	SLC27A6_ENST00000506176.1_Missense_Mutation_p.G244S|SLC27A6_ENST00000395266.1_Missense_Mutation_p.G244S			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	244					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GGTTTTAAGGGGTTCTGCTGT	0.398000													53	126					0	0	1	0	0
CST4	1472	broad.mit.edu	37	20	23667824	23667824	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23667824C>T	ENST00000217423.3	-	2	313	c.243G>A	c.(241-243)gtG>gtA	p.V81V		NM_001899.2	NP_001890.1	P01036	CYTS_HUMAN	cystatin S	81						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	16	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					AGAAGTAATTCACCCCCCCAA	0.557000													49	184					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93065419	93065419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:93065419C>T	ENST00000359558.2	-	14	1395	c.1096G>A	c.(1096-1098)Gag>Aag	p.E366K	CALCR_ENST00000394441.1_Missense_Mutation_p.E332K|CALCR_ENST00000421592.1_Missense_Mutation_p.E348K|CALCR_ENST00000360249.4_Missense_Mutation_p.E348K|CALCR_ENST00000426151.1_Missense_Mutation_p.E332K	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	348					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GATTCCGCCTCATGGGTTTCC	0.478000													21	56					0	0	1	0	0
AQP2	359	broad.mit.edu	37	12	50344655	50344655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50344655C>T	ENST00000199280.3	+	1	127	c.42C>T	c.(40-42)ttC>ttT	p.F14F		NM_000486.5	NP_000477.1	P41181	AQP2_HUMAN	aquaporin 2 (collecting duct)	14					cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(4)|ovary(2)	10						GGGCTGTGTTCGCAGAGTTCC	0.642000													24	40					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15561637	15561637	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:15561637C>T	ENST00000344577.2	-	2	238	c.213G>A	c.(211-213)agG>agA	p.R71R	LIPI_ENST00000536861.1_Silent_p.R50R	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	50					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTAGGTTGTTCCTTGTATACA	0.353000													29	101					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41853402	41853402	+	Missense_Mutation	SNP	G	G	A	rs148972694	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41853402G>A	ENST00000263798.3	+	2	426	c.202G>A	c.(202-204)Ggg>Agg	p.G68R	TYRO3_ENST00000559066.1_Missense_Mutation_p.G23R	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	68	Ig-like C2-type 1.					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CAGTGTGGAGGGGATGGAGGA	0.592000													8	72					0	0	1	0	0
ZNF235	9310	broad.mit.edu	37	19	44791515	44791515	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44791515G>A	ENST00000291182.4	-	5	2175	c.2073C>T	c.(2071-2073)ggC>ggT	p.G691G	ZNF235_ENST00000589248.1_Intron|ZNF235_ENST00000589799.1_Intron	NM_004234.4	NP_004225.3	Q14590	ZN235_HUMAN	zinc finger protein 235	691					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29		Prostate(69;0.0352)|all_neural(266;0.116)				CCTGACTGAAGCCCTTCCCAC	0.512000													24	98					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637427	248637427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248637427C>T	ENST00000359594.2	+	1	801	c.776C>T	c.(775-777)gCt>gTt	p.A259V		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCTTCGGTGCTTCCTTCTAC	0.552000													102	353					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75102019	75102019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75102019G>A	ENST00000326665.5	-	6	766	c.548C>T	c.(547-549)tCa>tTa	p.S183L		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	183										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCTGGACCTTGAAGTTACCTT	0.388000													66	201					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103068633	103068633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103068633G>A	ENST00000264260.2	+	12	2381	c.1792G>A	c.(1792-1794)Gaa>Aaa	p.E598K	IL18RAP_ENST00000409369.1_Missense_Mutation_p.E456K	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	598					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						CCAGCCTAAGGAATGGTGAAA	0.517000													40	77					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49701640	49701640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:49701640C>T	ENST00000303221.5	-	5	734	c.519G>A	c.(517-519)ggG>ggA	p.G173G	EMB_ENST00000514111.1_Silent_p.G123G|EMB_ENST00000506190.1_5'UTR|EMB_ENST00000508934.1_Silent_p.G119G	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	173	Ig-like V-type 2.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				CAGTAGAATCCCCTACGTAAG	0.348000													32	53					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940104	68940104	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:68940104G>A	ENST00000433211.1	-	7	1192	c.1018C>T	c.(1018-1020)Cag>Tag	p.Q340*	CTNNA3_ENST00000545309.1_Nonsense_Mutation_p.Q340*|CTNNA3_ENST00000494580.1_5'UTR|CTNNA3_ENST00000373744.4_Nonsense_Mutation_p.Q340*	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	340					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						AGCAGATCCTGAAGAGCCTGG	0.502000													18	63					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263531	140263531	+	Missense_Mutation	SNP	G	G	A	rs139225969	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140263531G>A	ENST00000289272.2	+	1	1678	c.1678G>A	c.(1678-1680)Gac>Aac	p.D560N	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.D560N|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGAGAACGACAACGCTCC	0.697000													47	114					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75015177	75015177	+	Missense_Mutation	SNP	C	C	T	rs77425771		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75015177C>T	ENST00000379727.3	-	2	460	c.262G>A	c.(262-264)Ggc>Agc	p.G88S	CYP1A1_ENST00000395049.4_Missense_Mutation_p.G88S|CYP1A1_ENST00000567032.1_Missense_Mutation_p.G88S|CYP1A1_ENST00000564596.1_Intron|CYP1A1_ENST00000395048.2_Missense_Mutation_p.G88S			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	88					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	GTGTCCAGGCCGCTCAGCACC	0.617000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				20	67					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201196111	201196111	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201196111G>A	ENST00000335211.4	+	23	11018	c.10888G>A	c.(10888-10890)Gag>Aag	p.E3630K	IGFN1_ENST00000295591.8_3'UTR	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CCAGGGCTGCGAGTGCTGCAT	0.677000													45	81					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43606197	43606197	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43606197G>A	ENST00000360835.3	-	19	2559	c.2433C>T	c.(2431-2433)tcC>tcT	p.S811S		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	811	CUB.				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GGTAGTTGGGGGACTCGATGT	0.652000													15	34					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924639	188924639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:188924639C>T	ENST00000326866.4	+	4	1086	c.678C>T	c.(676-678)ttC>ttT	p.F226F	ZFP42_ENST00000509524.1_Silent_p.F226F	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	226					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GGAAAGCGTTCGTTGAGAGCT	0.507000													30	76					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124952521	124952521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124952521G>A	ENST00000360647.4	-	9	1534	c.1049C>T	c.(1048-1050)tCt>tTt	p.S350F	ZNF148_ENST00000484491.1_Missense_Mutation_p.S350F|ZNF148_ENST00000468369.1_Intron|SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000544464.1_Intron|ZNF148_ENST00000485866.1_Missense_Mutation_p.S350F|ZNF148_ENST00000497929.1_5'UTR|ZNF148_ENST00000492394.1_Missense_Mutation_p.S350F	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	350					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						AGTACTTGAAGAATAAAGAGG	0.388000													33	120					0	0	1	0	0
GRB7	2886	broad.mit.edu	37	17	37898852	37898852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37898852C>T	ENST00000309156.4	+	3	446	c.189C>T	c.(187-189)tcC>tcT	p.S63S	GRB7_ENST00000394209.2_Silent_p.S63S|GRB7_ENST00000394211.3_Silent_p.S63S|GRB7_ENST00000394204.1_Silent_p.S63S|GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000445327.2_Silent_p.S86S|GRB7_ENST00000309185.3_Silent_p.S63S	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	63					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GTGCCACCTCCCTCCCCTCTA	0.627000													63	90					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48603334	48603334	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48603334G>A	ENST00000323776.5	+	14	2166	c.2004G>A	c.(2002-2004)ggG>ggA	p.G668G	MYCBPAP_ENST00000436259.2_Silent_p.G631G	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	631					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CCAGGCCAGGGGACAAGGAGC	0.597000													38	143					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55047005	55047005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55047005C>T	ENST00000335056.3	+	4	588	c.550C>T	c.(550-552)Cct>Tct	p.P184S	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		TTCCATGGGTCCTGTAACGCC	0.537000													25	72					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625129	74625129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74625129C>T	ENST00000156626.7	-	2	995	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K	ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	266					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						CTGTATTTTTCCTCAAAATCC	0.577000													48	99					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39442854	39442854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39442854G>A	ENST00000265707.5	+	2	160	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K	ADAM18_ENST00000520772.1_Missense_Mutation_p.E39K|ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.E39K	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	39					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AAATGACAGTGAAGTTTCAGA	0.313000													25	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179614236	179614236	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179614236C>T	ENST00000360870.5	-	46	13113	c.12891G>A	c.(12889-12891)tgG>tgA	p.W4297*	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	430	Ig-like 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACATTTGTCCAGGGAGTAA	0.398000													23	50					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119115959	119115959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119115959C>T	ENST00000328252.3	+	17	4603	c.4234C>T	c.(4234-4236)Cct>Tct	p.P1412S	PAPPA_ENST00000534838.1_Missense_Mutation_p.P450S	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1412	Sushi 3.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						AGCTTGTGTTCCTGTGACCTG	0.507000													44	76					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216243581	216243581	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216243581T>C	ENST00000366943.2	-	30	6297	c.5911A>G	c.(5911-5913)Att>Gtt	p.I1971V	USH2A_ENST00000307340.3_Missense_Mutation_p.I1971V			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1971	Fibronectin type-III 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTCACCTCAATGCTGTATCCA	0.478000										HNSCC(13;0.011)			26	52					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54603833	54603833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54603833G>A	ENST00000474759.1	+	7	736	c.688G>A	c.(688-690)Gaa>Aaa	p.E230K	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.E136K|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.E230K|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.E230K	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	230						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GATTAAATGGGAACCAGATGA	0.393000													6	13					0	0	1	0	0
CDC25C	995	broad.mit.edu	37	5	137665307	137665307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137665307G>A	ENST00000323760.6	-	3	502	c.224C>T	c.(223-225)tCg>tTg	p.S75L	CDC25C_ENST00000514555.1_Missense_Mutation_p.S75L|CDC25C_ENST00000513970.1_Missense_Mutation_p.S75L|CDC25C_ENST00000356505.3_Missense_Mutation_p.S75L|CDC25C_ENST00000357274.3_Intron|CDC25C_ENST00000348983.3_Intron|CDC25C_ENST00000415130.2_Intron	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	75					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GCTAAGATTCGAAAGATCGAG	0.423000													51	124					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98189116	98189116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98189116G>A	ENST00000332650.5	+	1	793	c.696G>A	c.(694-696)gaG>gaA	p.E232E		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AATCCAAAGAGGGAAGGGCCA	0.343000													42	97					0	0	1	0	0
SPINK7	84651	broad.mit.edu	37	5	147693757	147693757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147693757G>A	ENST00000274565.4	+	3	243	c.182G>A	c.(181-183)gGg>gAg	p.G61E	SPINK7_ENST00000514394.1_3'UTR|RP11-373N22.3_ENST00000501695.3_RNA|SPINK7_ENST00000523535.1_Missense_Mutation_p.G35E	NM_032566.2	NP_115955.1	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7 (putative)	61	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCACCTATGGGAATGAATGT	0.463000													16	123					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358659	72358659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72358659G>A	ENST00000441259.1	-	3	978	c.818C>T	c.(817-819)tCt>tTt	p.S273F	PRF1_ENST00000373209.2_Missense_Mutation_p.S273F	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	273	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						GGCTTCGGCAGAGATGCTGCC	0.622000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				24	86					0	0	1	0	0
SLC1A2	6506	broad.mit.edu	37	11	35339031	35339031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:35339031C>T	ENST00000278379.3	-	2	332	c.50G>A	c.(49-51)cGa>cAa	p.R17Q	SLC1A2_ENST00000395750.1_Missense_Mutation_p.R8Q|SLC1A2_ENST00000395753.1_Missense_Mutation_p.R8Q|SLC1A2_ENST00000606205.1_Missense_Mutation_p.R17Q	NM_004171.3	NP_004162.2	P43004	EAA2_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 2	17					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|urinary_tract(1)	24	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	GTCGTGCATTCGCACTTCCAC	0.567000													88	117					0	0	1	0	0
ALG9	79796	broad.mit.edu	37	11	111708198	111708198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111708198G>A	ENST00000398006.2	-	12	1839	c.931C>T	c.(931-933)Cct>Tct	p.P311S	ALG9_ENST00000524880.1_3'UTR|ALG9_ENST00000531154.1_Missense_Mutation_p.P318S|ALG9_ENST00000527228.1_5'UTR	NM_001077690.1|NM_001077691.1|NM_001077692.1	NP_001071158.1|NP_001071159.1|NP_001071160.1	Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	482					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		TACTTGTCAGGAAGAAGGAAG	0.408000													24	52					0	0	1	0	0
LALBA	3906	broad.mit.edu	37	12	48963801	48963801	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48963801C>T	ENST00000549817.1	-	1	48	c.3G>A	c.(1-3)atG>atA	p.M1I	LALBA_ENST00000301046.2_Start_Codon_SNP_p.M1I			P00709	LALBA_HUMAN	lactalbumin, alpha-	1					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity			large_intestine(1)|stomach(2)	3						CAAAGAACCTCATTTTGGCTA	0.483000													41	81					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40728919	40728919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40728919C>T	ENST00000298910.7	+	40	5966	c.5908C>T	c.(5908-5910)Cta>Tta	p.L1970L		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1970	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CACTAGAACCCTACAGCACAG	0.517000													19	62					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98512567	98512567	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:98512567C>T	ENST00000268042.6	+	5	1004	c.840C>T	c.(838-840)tcC>tcT	p.S280S	ARRDC4_ENST00000538249.1_Silent_p.S193S	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	280					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TTACTCCATCCATCCTGGATT	0.428000													60	59					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61602272	61602272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61602272C>T	ENST00000238508.3	+	8	1049	c.990C>T	c.(988-990)aaC>aaT	p.N330N	AC009802.1_ENST00000599868.1_Intron	NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				CAGCAAGAAACCTATTTTTGT	0.413000													30	55					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119926647	119926647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119926647C>T	ENST00000327554.2	+	5	998	c.533C>T	c.(532-534)cCt>cTt	p.P178L	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	178										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		ACCATGAAGCCTGTGATCACC	0.547000													26	60					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143995719	143995719	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143995719C>A	ENST00000323110.2	-	5	917	c.915G>T	c.(913-915)aaG>aaT	p.K305N		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	305					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TAGAGTTGGCCTTGATGGCTT	0.587000									Familial Hyperaldosteronism type I				17	24					1.00905e-13	1.01412e-13	1	1	0
TIAM2	26230	broad.mit.edu	37	6	155458470	155458470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155458470G>A	ENST00000461783.3	+	7	2627	c.1354G>A	c.(1354-1356)Gat>Aat	p.D452N	TIAM2_ENST00000318981.5_Missense_Mutation_p.D452N|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000529824.2_Missense_Mutation_p.D452N|TIAM2_ENST00000360366.4_Missense_Mutation_p.D452N|TIAM2_ENST00000456144.1_Missense_Mutation_p.D452N			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	452					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GATTGGCAGCGATCCCCTCCG	0.502000													53	50					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38776168	38776168	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:38776168C>T	ENST00000308973.4	-	4	1649	c.1044G>A	c.(1042-1044)acG>acA	p.T348T	TLR10_ENST00000508334.1_Silent_p.T348T|TLR10_ENST00000361424.2_Silent_p.T348T|TLR10_ENST00000506111.1_Silent_p.T348T	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	348					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity	p.T348T(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						ATTGGAATTTCGTAGGATAAT	0.328000													38	113					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72040764	72040764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72040764C>T	ENST00000355327.3	+	14	2380	c.2246C>T	c.(2245-2247)tCg>tTg	p.S749L	THSD4_ENST00000261862.6_Missense_Mutation_p.S749L|THSD4_ENST00000357769.4_Missense_Mutation_p.S389L|THSD4_ENST00000567838.1_3'UTR			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	749	TSP type-1 3.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TTTCAGTGCTCGGTGCCCTGC	0.577000													13	66					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42231188	42231188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42231188G>A	ENST00000541110.1	-	8	2322	c.1754C>T	c.(1753-1755)cCc>cTc	p.P585L	TRERF1_ENST00000340840.2_Intron|TRERF1_ENST00000354325.2_Intron|TRERF1_ENST00000372917.4_Intron|TRERF1_ENST00000372922.4_Missense_Mutation_p.P585L			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	585	Interacts with CREBBP.|Pro-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GACAGACACGGGCATGACCAT	0.692000													21	70					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46609673	46609673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:46609673C>T	ENST00000263734.3	+	15	2907	c.2397C>T	c.(2395-2397)ttC>ttT	p.F799F		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	799					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AGAGCAGGTTCCCCCCACAGT	0.637000													24	84					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89939785	89939785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89939785G>A	ENST00000405460.2	+	14	2815	c.2719G>A	c.(2719-2721)Gat>Aat	p.D907N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	907					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGCAAAGGAGATGCTATCTA	0.274000													5	19					0	0	1	0	0
CD276	80381	broad.mit.edu	37	15	73996519	73996519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73996519C>T	ENST00000318443.5	+	6	1377	c.1075C>T	c.(1075-1077)Ccc>Tcc	p.P359S	CD276_ENST00000537340.2_Missense_Mutation_p.P213S|CD276_ENST00000564751.1_Missense_Mutation_p.P141S|CD276_ENST00000318424.5_Missense_Mutation_p.P141S|CD276_ENST00000561213.1_Missense_Mutation_p.P359S	NM_001024736.1	NP_001019907.1	Q5ZPR3	CD276_HUMAN	CD276 molecule	359					cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						ACCTCCAGCTCCCTACTCGAA	0.637000													6	22					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156929952	156929952	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156929952C>T	ENST00000257527.4	-	12	1245	c.1167G>A	c.(1165-1167)agG>agA	p.R389R	ADAM19_ENST00000430702.2_Silent_p.R122R|ADAM19_ENST00000517905.1_Silent_p.R389R|ADAM19_ENST00000394020.1_Silent_p.R391R	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	389	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCAGCTCCCTCCTGTTGCATC	0.552000													38	81					0	0	1	0	0
P2RX7	5027	broad.mit.edu	37	12	121593887	121593887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121593887C>T	ENST00000546057.1	+	3	443	c.300C>T	c.(298-300)aaC>aaT	p.N100N	P2RX7_ENST00000328963.5_5'UTR|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000535250.1_Silent_p.N10N|P2RX7_ENST00000377162.2_Silent_p.N100N|P2RX7_ENST00000541446.1_5'UTR	NM_002562.5	NP_002553.3	A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	100						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CACAGGGGAACTCTTTCTTCG	0.473000													39	95					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79733273	79733273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79733273C>T	ENST00000338008.5	+	3	949	c.769C>T	c.(769-771)Cat>Tat	p.H257Y	ZFYVE16_ENST00000510158.1_Missense_Mutation_p.H257Y|ZFYVE16_ENST00000505560.1_Missense_Mutation_p.H257Y	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	257					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		CAAAATGTTTCATGCCAAAGA	0.353000													26	94					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	175995723	175995723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:175995723C>T	ENST00000510636.1	+	4	443	c.169C>T	c.(169-171)Cct>Tct	p.P57S	CDHR2_ENST00000261944.5_Missense_Mutation_p.P57S|CDHR2_ENST00000506348.1_Missense_Mutation_p.P57S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	57	Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GGACAATGACCCTCTGACCTA	0.597000													16	80					0	0	1	0	0
C1orf141	400757	broad.mit.edu	37	1	67559037	67559037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:67559037G>A	ENST00000371007.2	-	8	963	c.854C>T	c.(853-855)tCt>tTt	p.S285F	C1orf141_ENST00000371006.1_Missense_Mutation_p.S285F|C1orf141_ENST00000544837.1_Missense_Mutation_p.S285F	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	285										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						CGCTTTAAAAGACATAGGGAT	0.333000													25	107					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53207919	53207919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53207919C>T	ENST00000293774.4	-	1	416	c.146G>A	c.(145-147)cGa>cAa	p.R49Q	KRT4_ENST00000551956.1_5'UTR			B4DRS2	B4DRS2_HUMAN	keratin 4	0						keratin filament	structural molecule activity	p.R49P(1)		endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CCTCAGCCTTCGTCTCTTATA	0.567000													6	44					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55352346	55352346	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:55352346C>T	ENST00000536015.1	-	14	1550	c.1429_splice	c.e14-1	p.G477_splice	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Splice_Site_p.G477_splice|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	477					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				CCCGATGGTCCCCTGAGAAAC	0.473000													9	123					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181538	128181538	+	Missense_Mutation	SNP	G	G	A	rs140414363		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:128181538G>A	ENST00000469083.1	-	2	3108	c.551C>T	c.(550-552)tCg>tTg	p.S184L	DNAJB8_ENST00000319153.3_Missense_Mutation_p.S184L			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	184					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		CTCGGTGGACGACATCACCGA	0.622000													37	70					0	0	1	0	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	98995059	98995059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98995059G>A	ENST00000453547.2	-	9	1198	c.1199C>T	c.(1198-1200)tCa>tTa	p.S400L	ARHGAP19_ENST00000487035.1_5'UTR|ARHGAP19-SLIT1_ENST00000316676.8_Missense_Mutation_p.S400L|ARHGAP19_ENST00000355366.5_Missense_Mutation_p.S391L|ARHGAP19_ENST00000358531.4_Missense_Mutation_p.S400L|ARHGAP19-SLIT1_ENST00000358308.3_Missense_Mutation_p.S371L|ARHGAP19_ENST00000371027.1_Missense_Mutation_p.S391L																							CTGGGTCAATGATTGCTTATT	0.418000													43	109					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60768077	60768077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60768077G>A	ENST00000303375.5	+	27	4369	c.3967G>A	c.(3967-3969)Ggc>Agc	p.G1323S	MRC2_ENST00000446119.2_Missense_Mutation_p.G189S	NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1323	C-type lectin 8.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GAGCTATGAGGGCCAGAGTCG	0.612000													18	48					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870938	51870938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51870938C>T	ENST00000371497.5	+	2	1828	c.941C>T	c.(940-942)tCg>tTg	p.S314L	TSHZ2_ENST00000603338.2_Missense_Mutation_p.S311L|TSHZ2_ENST00000329613.6_Missense_Mutation_p.S311L	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	314					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			ACCATTTCCTCGAAAATGGTC	0.458000													10	100					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45802612	45802612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45802612C>T	ENST00000397928.1	+	9	1672	c.1227C>T	c.(1225-1227)atC>atT	p.I409I	TRPM2_ENST00000300481.9_Silent_p.I409I|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Silent_p.I409I|TRPM2_ENST00000397932.2_Silent_p.I409I	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	409						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TCCAAGATATCGTCCGGAGGC	0.562000													7	24					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155450443	155450443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155450443C>T	ENST00000461783.3	+	6	1359	c.86C>T	c.(85-87)tCc>tTc	p.S29F	TIAM2_ENST00000318981.5_Missense_Mutation_p.S29F|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000529824.2_Missense_Mutation_p.S29F|TIAM2_ENST00000360366.4_Missense_Mutation_p.S29F|TIAM2_ENST00000456144.1_Missense_Mutation_p.S29F			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	29					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		ATTCCTTGCTCCCTGAAAATA	0.448000													18	52					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154543767	154543767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154543767G>A	ENST00000368476.3	+	5	732	c.468G>A	c.(466-468)aaG>aaA	p.K156K		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	156					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity	p.K156N(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	GCGCATGCAAGATTGAAGTAA	0.527000													38	53					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147900526	147900526	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147900526C>T	ENST00000362016.2	-	6	671	c.507_splice	c.e6-1	p.E170_splice	HTR4_ENST00000360693.3_Intron|HTR4_ENST00000517929.1_Intron|HTR4_ENST00000520514.1_Intron|HTR4_ENST00000314512.6_Intron|HTR4_ENST00000521530.1_Intron|HTR4_ENST00000521735.1_Intron|HTR4_ENST00000377888.3_Intron|HTR4_ENST00000354217.2_Intron			Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	169					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AGACTCCTTTCCTTGAAAAAG	0.478000													25	53					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37673727	37673727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37673727C>T	ENST00000447079.4	+	10	2914	c.2881C>T	c.(2881-2883)Cct>Tct	p.P961S	CDK12_ENST00000430627.2_Missense_Mutation_p.P961S	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	961	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						AGCTGTGTGGCCTGATGTTAT	0.448000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			53	114					0	0	1	0	0
AMHR2	269	broad.mit.edu	37	12	53823694	53823694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53823694G>A	ENST00000257863.4	+	9	1300	c.1220G>A	c.(1219-1221)cGa>cAa	p.R407Q	AMHR2_ENST00000550311.1_Missense_Mutation_p.R407Q|AMHR2_ENST00000379791.3_Intron	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	407	Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	GCCCTCCGACGAGCTGATATT	0.582000													19	52					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158577134	158577134	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158577134G>A	ENST00000361284.1	+	1	906	c.906G>A	c.(904-906)agG>agA	p.R302R		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					CAGCTCTGAGGAATGCTTTCA	0.458000													72	191					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238592	104238592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104238592C>T	ENST00000374851.1	-	4	1930	c.783G>A	c.(781-783)cgG>cgA	p.R261R	RP11-490D19.6_ENST00000431507.1_RNA|TMEM246_ENST00000374847.1_Silent_p.R261R|RP11-490D19.6_ENST00000450109.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374848.3_Silent_p.R261R			Q9BRR3	CI125_HUMAN	transmembrane protein 246	261						integral to membrane											ATTCCAGGATCCGCATGGGCT	0.552000													61	71					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50958867	50958867	+	Silent	SNP	C	C	T	rs145465195	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50958867C>T	ENST00000357701.5	+	20	2355	c.2304C>T	c.(2302-2304)atC>atT	p.I768I		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	768	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle	p.I768I(1)		breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CAGGTGGCATCGATGGGTACC	0.622000													12	88					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170019096	170019096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170019096G>A	ENST00000263816.3	-	63	12058	c.11773C>T	c.(11773-11775)Cct>Tct	p.P3925S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3925					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAAGGTTTAGGGGTCGGTTTT	0.388000													21	61					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60696259	60696259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60696259C>T	ENST00000005286.4	+	4	846	c.693C>T	c.(691-693)gcC>gcT	p.A231A	TMEM132A_ENST00000453848.2_Silent_p.A231A	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	231						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GGGAGCAGGCCCTCCCAGTGG	0.701000													12	20					0	0	1	0	0
CXXC1	30827	broad.mit.edu	37	18	47812438	47812438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47812438G>A	ENST00000285106.6	-	4	1127	c.413C>T	c.(412-414)tCg>tTg	p.S138L	CXXC1_ENST00000412036.2_Missense_Mutation_p.S138L|CXXC1_ENST00000589940.1_Missense_Mutation_p.S138L	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	138					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						TTTGTGGGGCGAAGCAGAGCC	0.632000													27	71					0	0	1	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77492582	77492582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77492582G>A	ENST00000238647.3	-	1	2452	c.1554C>T	c.(1552-1554)ccC>ccT	p.P518P		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	518						nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						ggggtgcgctgggggcgcggc	0.766000													5	4					0	0	1	0	0
STAT1	6772	broad.mit.edu	37	2	191874651	191874651	+	Missense_Mutation	SNP	G	G	A	rs11549696		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:191874651G>A	ENST00000361099.3	-	3	466	c.79C>T	c.(79-81)Ccc>Tcc	p.P27S	STAT1_ENST00000409465.1_Missense_Mutation_p.P27S|STAT1_ENST00000392322.3_Missense_Mutation_p.P27S|STAT1_ENST00000540176.1_Missense_Mutation_p.P27S|STAT1_ENST00000392323.2_Missense_Mutation_p.P29S	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	27					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	ATTTCCATGGGAAAACTGTCA	0.408000													10	186					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58111348	58111348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58111348C>T	ENST00000357272.4	+	23	4104	c.3939C>T	c.(3937-3939)atC>atT	p.I1313I	FLNB_ENST00000493452.1_Silent_p.I1144I|FLNB_ENST00000490882.1_Silent_p.I1313I|FLNB_ENST00000429972.2_Silent_p.I1313I|FLNB_ENST00000419752.2_Silent_p.I1144I|FLNB_ENST00000348383.5_Silent_p.I1313I|FLNB_ENST00000295956.4_Silent_p.I1313I|FLNB_ENST00000358537.3_Silent_p.I1313I			O75369	FLNB_HUMAN	filamin B, beta	1313	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ACGTGCCTATCCCAAACAGTC	0.473000													38	85					0	0	1	0	0
FBP2	8789	broad.mit.edu	37	9	97355969	97355969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:97355969G>A	ENST00000375337.3	-	1	106	c.40C>T	c.(40-42)Ctg>Ttg	p.L14L		NM_003837.2	NP_003828.2	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	14					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding			endometrium(1)|large_intestine(3)|lung(5)	9		Acute lymphoblastic leukemia(62;0.136)				TAGCGGGTCAGGGTGAGCATG	0.552000													12	51					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50052708	50052708	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50052708C>T	ENST00000376042.1	+	6	1837	c.1539C>T	c.(1537-1539)acC>acT	p.T513T	CCNB3_ENST00000276014.7_Silent_p.T513T|CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000376038.1_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	513					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TACAGACCACCTCTGGAGAAA	0.428000													7	27					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56954855	56954855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56954855C>T	ENST00000497933.1	+	2	1074	c.927C>T	c.(925-927)ttC>ttT	p.F309F		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	279	Poly-Glu.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						TCGTGGGCTTCGTGGTCTCCA	0.582000													20	68					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87645063	87645063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87645063C>T	ENST00000320005.5	-	11	1284	c.1237G>A	c.(1237-1239)Gaa>Aaa	p.E413K		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	413					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						GTTTGTGGTTCTGGAAGGCCA	0.323000													17	44					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234357778	234357778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234357778C>T	ENST00000264057.2	+	15	1656	c.1644C>T	c.(1642-1644)tcC>tcT	p.S548S	DGKD_ENST00000409813.3_Silent_p.S504S	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	548					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	AGCTGGATTCCCTTCTCAAGA	0.587000													57	144					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163241215	163241215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163241215C>T	ENST00000332142.5	-	13	3044	c.2945G>A	c.(2944-2946)aGa>aAa	p.R982K		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	982					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AGAGTGACTTCTTTTATCTAT	0.408000													13	162					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987389	61987389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61987389G>A	ENST00000450719.3	-	3	559	c.322C>T	c.(322-324)Ctc>Ttc	p.L108F	CSHL1_ENST00000438387.2_Intron|CSHL1_ENST00000346606.6_Intron|CSHL1_ENST00000309894.5_Intron|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000561003.1_Missense_Mutation_p.L119F|CSHL1_ENST00000259003.10_Intron|CSHL1_ENST00000558099.1_5'UTR			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	0						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						GGATTCACGAGGGGAAATGAA	0.542000													43	110					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649270	75649270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:75649270C>T	ENST00000361470.2	+	1	1225	c.947C>T	c.(946-948)tCg>tTg	p.S316L		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	316	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						GGTGAGGGATCGAGCACCTCC	0.711000													4	19					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52308303	52308303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52308303G>A	ENST00000550683.1	+	5	849	c.748G>A	c.(748-750)Gaa>Aaa	p.E250K	ACVRL1_ENST00000419526.2_Missense_Mutation_p.E62K|ACVRL1_ENST00000388922.4_Missense_Mutation_p.E236K	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	236	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CTCGAGGGATGAACAGTCCTG	0.592000													13	25					0	0	1	0	0
ZNF345	25850	broad.mit.edu	37	19	37368402	37368402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37368402C>T	ENST00000529555.1	+	2	1458	c.670C>T	c.(670-672)Cat>Tat	p.H224Y	ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000420450.1_Missense_Mutation_p.H224Y|ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000589046.1_Missense_Mutation_p.H224Y			Q14585	ZN345_HUMAN	zinc finger protein 345	224					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCGGCGGATTCATACTGGTGA	0.448000													7	109					0	0	1	0	0
KCTD17	79734	broad.mit.edu	37	22	37457582	37457582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37457582C>T	ENST00000403888.3	+	8	810	c.809C>T	c.(808-810)tCc>tTc	p.S270F	KCTD17_ENST00000402077.3_Missense_Mutation_p.S246F			Q8N5Z5	KCD17_HUMAN	potassium channel tetramerization domain containing 17	270	Pro-rich.					voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity			NS(1)|breast(1)|endometrium(1)|lung(1)|prostate(1)	5						CTTGCAGGTTCCCGTCCGCAC	0.677000													6	21					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	601394	601394	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:601394C>T	ENST00000219611.2	+	8	2522	c.2159C>T	c.(2158-2160)tCc>tTc	p.S720F	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		CATGCCTACTCCATCCTGGAT	0.662000													16	63					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189855065	189855065	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189855065C>T	ENST00000304636.3	+	10	947	c.777C>T	c.(775-777)ttC>ttT	p.F259F	COL3A1_ENST00000317840.5_Silent_p.F259F	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	259	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TACCTGGATTCCCTGGTATGA	0.348000													15	30					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201190778	201190778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201190778G>A	ENST00000335211.4	+	19	10235	c.10105G>A	c.(10105-10107)Gga>Aga	p.G3369R	IGFN1_ENST00000295591.8_Missense_Mutation_p.G529R	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCTTCGGCCTGGAGAGGGCTA	0.607000													14	32					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33572868	33572868	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33572868G>A	ENST00000262873.7	+	11	959		c.e11-1			NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta							membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TCTGCCCACAGGGCAAGTTCA	0.662000													27	92					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553608	140553608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140553608G>A	ENST00000231137.3	+	1	1366	c.1192G>A	c.(1192-1194)Gaa>Aaa	p.E398K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		398	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.E398K(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCATCTGTCGAAAACTTCTA	0.493000													36	53					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122664263	122664263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:122664263C>T	ENST00000263461.6	+	25	3379	c.3133C>T	c.(3133-3135)Ccc>Tcc	p.P1045S	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	1045						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						CTCGTCAGGCCCCTCTCAGAG	0.443000													29	90					0	0	1	0	0
TRBV6-1	28606	broad.mit.edu	37	7	142028454	142028454	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142028454G>A	ENST00000390353.2	+	0	245																											ATGGGACTGAGGCTGATTTAT	0.498000													45	193					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189068185	189068185	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189068185G>A	ENST00000332517.3	+	6	1206	c.1066G>A	c.(1066-1068)Ggc>Agc	p.G356S	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	356	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GTGGGAAGTGGGCATCTGCAA	0.517000													16	68					0	0	1	0	0
GPR6	2830	broad.mit.edu	37	6	110301203	110301203	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110301203C>T	ENST00000414000.2	+	3	1172	c.933C>T	c.(931-933)gcC>gcT	p.A311A	GPR6_ENST00000275169.3_Silent_p.A296A			P46095	GPR6_HUMAN	G protein-coupled receptor 6	296						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		TGCCCTTCGCCATCTATTGCG	0.622000													5	46					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10563949	10563949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10563949G>A	ENST00000344979.3	+	1	335	c.10G>A	c.(10-12)Gtg>Atg	p.V4M	PDE4A_ENST00000293683.5_Intron|PDE4A_ENST00000592685.1_Intron|PDE4A_ENST00000380702.2_Intron|PDE4A_ENST00000352831.6_Intron|PDE4A_ENST00000440014.2_Intron	NM_006202.2	NP_006193.1	P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	0					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	GATGCCCTTGGTGGATTTCTT	0.652000													9	27					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63883944	63883944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63883944G>A	ENST00000246841.3	+	2	1248	c.205G>A	c.(205-207)Gac>Aac	p.D69N	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	41					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CTACTGCAACGACCGGGGACT	0.607000													23	44					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8476354	8476354	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8476354C>T	ENST00000447869.1	-	6	1641	c.723G>A	c.(721-723)ctG>ctA	p.L241L	STK33_ENST00000396673.1_Silent_p.L241L|STK33_ENST00000315204.1_Silent_p.L241L|STK33_ENST00000396672.1_Silent_p.L241L|STK33_ENST00000358872.3_Silent_p.L54L|STK33_ENST00000534493.1_Silent_p.L200L			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	241	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		TTATATTTTCCAGTTTCAGAT	0.259000													10	52					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211523399	211523399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211523399G>A	ENST00000233072.5	+	31	3939	c.3743G>A	c.(3742-3744)gGa>gAa	p.G1248E	CPS1_ENST00000430249.2_Missense_Mutation_p.G1254E|CPS1_ENST00000451903.2_Missense_Mutation_p.G797E	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1248	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTTGTCAAAGGAAATGATGTC	0.433000													7	62					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17543308	17543308	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17543308C>T	ENST00000229922.2	+	11	1675	c.1143C>T	c.(1141-1143)ctC>ctT	p.L381L	CAP2_ENST00000493172.1_Silent_p.L121L|CAP2_ENST00000465994.1_Silent_p.L317L|CAP2_ENST00000489374.1_Silent_p.L269L|CAP2_ENST00000378990.2_Silent_p.L355L	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	381	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			GTAAAAAACTCGGCCTGGTGT	0.403000													74	158					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125528104	125528104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:125528104C>T	ENST00000241305.3	-	9	1391	c.1237G>A	c.(1237-1239)Gag>Aag	p.E413K	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	413					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		ATCCGCGTCTCCTCCACCAGG	0.632000													42	79					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71740870	71740870	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:71740870G>C	ENST00000269500.5	-	10	1466	c.1131C>G	c.(1129-1131)ccC>ccG	p.P377P	FBXO15_ENST00000580806.1_5'UTR|FBXO15_ENST00000419743.2_Silent_p.P453P	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	377										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		AGCTGTCAGAGGGTGTGGCAG	0.522000													63	212					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172544728	172544728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:172544728C>T	ENST00000367723.3	+	11	1829	c.1705C>T	c.(1705-1707)Cct>Tct	p.P569S	SUCO_ENST00000263688.3_Missense_Mutation_p.P410S	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		ACAGAGTTTCCCTTTAGATGA	0.308000													6	62					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	76958702	76958702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76958702C>T	ENST00000257626.7	-	21	1759	c.1681G>A	c.(1681-1683)Gga>Aga	p.G561R	GSAP_ENST00000440473.1_Intron	NM_017439.3	NP_059135.2			gamma-secretase activating protein																		CTTCTTTTTCCTGTTTTCTAG	0.378000													15	40					0	0	1	0	0
ENGASE	64772	broad.mit.edu	37	17	77078205	77078205	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:77078205C>T	ENST00000539857.2	+	6	955	c.540C>T	c.(538-540)ttC>ttT	p.F180F	ENGASE_ENST00000584568.1_Intron|ENGASE_ENST00000579016.1_Intron			Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	0						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						GACCTCATTTCCTCATGGACC	0.607000													11	29					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81110977	81110977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81110977G>A	ENST00000228644.3	+	1	287	c.135G>A	c.(133-135)gaG>gaA	p.E45E		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	45					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						ACAAAGCAGAGCTGCAGGGCT	0.622000													18	24					0	0	1	0	0
GSTA3	2940	broad.mit.edu	37	6	52761661	52761661	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52761661C>T	ENST00000211122.3	-	7	677	c.612G>A	c.(610-612)agG>agA	p.R204R	GSTA3_ENST00000370968.1_Silent_p.R154R	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	204	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	CGGGAGGCTTCCTTGGGCTGC	0.473000													29	111					0	0	1	0	0
ALDH7A1	501	broad.mit.edu	37	5	125919701	125919701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:125919701G>A	ENST00000409134.3	-	4	535	c.316C>T	c.(316-318)Cct>Tct	p.P106S	ALDH7A1_ENST00000447989.2_Missense_Mutation_p.P133S|ALDH7A1_ENST00000413020.1_5'UTR|ALDH7A1_ENST00000553117.1_Missense_Mutation_p.P106S	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	106					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	TTTGGAGCAGGAATCTAAGAA	0.348000													29	50					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61982370	61982370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61982370C>T	ENST00000370263.4	-	5	614	c.393G>A	c.(391-393)ggG>ggA	p.G131G	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	131					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CCGCGAAGTCCCCGTCAGCAC	0.652000													6	35					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169825875	169825875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169825875C>T	ENST00000263817.6	-	16	2120	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	666	Interaction with HAX1 (By similarity).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ATGTCCTCTTCATTAAGAGCT	0.368000													11	26					0	0	1	0	0
CD69	969	broad.mit.edu	37	12	9907256	9907256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9907256C>T	ENST00000228434.3	-	4	498	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	CD69_ENST00000536709.1_Missense_Mutation_p.E140K	NM_001781.2	NP_001772.1	Q07108	CD69_HUMAN	CD69 molecule	140	C-type lectin.					integral to plasma membrane	sugar binding|transmembrane receptor activity			endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)	10						ACCCAGTGTTCCTCTCTACCT	0.393000													83	186					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064856	9064856	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9064856C>T	ENST00000397910.4	-	3	22793	c.22590G>A	c.(22588-22590)agG>agA	p.R7530R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7532	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTGAATTTTCCTAGTGTTAG	0.473000													26	70					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21132126	21132126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21132126C>T	ENST00000261383.3	-	11	1633	c.1634G>A	c.(1633-1635)cGg>cAg	p.R545Q	CTC-508F8.1_ENST00000575612.1_RNA|DNAH3_ENST00000415178.1_Missense_Mutation_p.R545Q	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	545	Stem (By similarity).		R -> W (in dbSNP:rs16970910).		ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CACACATTGCCGATCAGCAGC	0.493000													11	27					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126398344	126398344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126398344G>A	ENST00000394329.3	+	13	12341	c.12328G>A	c.(12328-12330)Gga>Aga	p.G4110R	FAT4_ENST00000335110.5_Missense_Mutation_p.G2373R	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4110	Laminin G-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGTTACAGTTGGAGGTATCAG	0.353000													57	121					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166170230	166170230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166170230C>T	ENST00000357398.3	+	9	1425	c.1135C>T	c.(1135-1137)Cgt>Tgt	p.R379C	SCN2A_ENST00000375437.2_Missense_Mutation_p.R379C|SCN2A_ENST00000375427.2_Missense_Mutation_p.R379C|SCN2A_ENST00000283256.6_Missense_Mutation_p.R379C			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	379					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R379C(1)		NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTCCTTATTTCGTCTCATGAC	0.413000													27	99					0	0	1	0	0
MXRA8	54587	broad.mit.edu	37	1	1290115	1290115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1290115G>A	ENST00000309212.6	-	5	926	c.896C>T	c.(895-897)cCc>cTc	p.P299L	MXRA8_ENST00000342753.4_Missense_Mutation_p.P198L|MXRA8_ENST00000445648.2_Missense_Mutation_p.P299L	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	299						integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCCCCGGGGGGGCGGCTCCGC	0.731000													7	19					0	0	1	0	0
TIAL1	7073	broad.mit.edu	37	10	121337200	121337200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:121337200G>A	ENST00000369092.4	-	9	1544	c.236C>T	c.(235-237)cCa>cTa	p.P79L	TIAL1_ENST00000369093.2_Missense_Mutation_p.P219L|TIAL1_ENST00000436547.2_Missense_Mutation_p.P202L			Q01085	TIAR_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein-like 1	202	RRM 1.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(3)|ovary(1)	13		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		ACAATTTTTTGGACTTGACTG	0.368000													59	144					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87229775	87229775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87229775G>A	ENST00000297524.3	-	3	1206	c.1103C>T	c.(1102-1104)tCa>tTa	p.S368L	SLC7A13_ENST00000419776.2_Missense_Mutation_p.S359L	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	368						integral to membrane	amino acid transmembrane transporter activity	p.S368L(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						AGACCATAATGAACCCGTGAA	0.323000													13	56					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9307218	9307218	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9307218G>A	ENST00000261336.2	-	29	3796	c.3768C>T	c.(3766-3768)tcC>tcT	p.S1256S	PZP_ENST00000381997.2_Silent_p.S1042S	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TGACCTGGGTGGAGGAGAAAC	0.512000													9	19					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38318867	38318867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38318867C>T	ENST00000311856.4	+	10	1616	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S		NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	523						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		CTCTAGGTCCCCCAAATCAGT	0.542000													27	73					0	0	1	0	0
SENP1	29843	broad.mit.edu	37	12	48477508	48477508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48477508G>A	ENST00000004980.5	-	6	896	c.418C>T	c.(418-420)Cac>Tac	p.H140Y	SENP1_ENST00000549595.1_Missense_Mutation_p.H140Y|SENP1_ENST00000549518.1_Missense_Mutation_p.H140Y|SENP1_ENST00000339976.6_3'UTR|SENP1_ENST00000448372.1_Missense_Mutation_p.H140Y|SENP1_ENST00000551330.1_Missense_Mutation_p.H140Y|SENP1_ENST00000547886.1_5'UTR			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	140	Ser-rich.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				ACATGGCAGTGATGGTTTGAC	0.358000													32	70					0	0	1	0	0
SERTAD2	9792	broad.mit.edu	37	2	64863228	64863228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:64863228G>A	ENST00000313349.3	-	2	1075	c.778C>T	c.(778-780)Ccc>Tcc	p.P260S		NM_014755.2	NP_055570.1	Q14140	SRTD2_HUMAN	SERTA domain containing 2	260					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|skin(1)	12						GAAGTGCAGGGGTCAAAATCA	0.512000													22	53					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35801756	35801756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35801756C>T	ENST00000342694.2	+	8	1808	c.1553C>T	c.(1552-1554)tCg>tTg	p.S518L		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	518	Protein kinase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CTCACACTGTCGCTGGTGAGC	0.542000													19	95					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102959618	102959618	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102959618G>A	ENST00000311734.2	+	7	1144	c.805G>A	c.(805-807)Gag>Aag	p.E269K	IL1RL1_ENST00000404917.2_Missense_Mutation_p.E152K|IL1RL1_ENST00000233954.1_Missense_Mutation_p.E269K|IL1RL1_ENST00000409584.1_Missense_Mutation_p.E255K			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	269	Ig-like C2-type 3.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						AATTCAACAAGAGGAAGGGCA	0.418000													30	132					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47041196	47041196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:47041196C>T	ENST00000377604.3	+	15	2366	c.1624C>T	c.(1624-1626)Cct>Tct	p.P542S	RBM10_ENST00000345781.6_Missense_Mutation_p.P465S|RBM10_ENST00000468791.1_Intron|RBM10_ENST00000329236.7_Missense_Mutation_p.P464S	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	542					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						GCTCCAGAGCCCTACCCATCC	0.602000													3	23					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92346621	92346621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:92346621G>A	ENST00000276609.3	+	6	980	c.741G>A	c.(739-741)ctG>ctA	p.L247L	SLC26A7_ENST00000523719.1_Silent_p.L247L|SLC26A7_ENST00000309536.2_Silent_p.L247L	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	247						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TTAAAGAGCTGAATGAACAGT	0.338000													25	54					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25232061	25232061	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25232061G>A	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						GGAGTGGTAGGAGGAGGGTTG	0.463000													18	45					0	0	1	0	0
OTX2	5015	broad.mit.edu	37	14	57270922	57270922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:57270922G>A	ENST00000339475.5	-	4	533	c.257C>T	c.(256-258)cCc>cTc	p.P86L	OTX2_ENST00000555006.1_Missense_Mutation_p.P78L|OTX2_ENST00000408990.3_Missense_Mutation_p.P78L|OTX2_ENST00000554788.1_Intron|OTX2_ENST00000554559.1_Intron	NM_001270523.1|NM_001270524.1|NM_001270525.1|NM_021728.3	NP_001257452.1|NP_001257453.1|NP_001257454.1|NP_068374.1	P32243	OTX2_HUMAN	orthodenticle homeobox 2	78					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	19	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CCTCGACTCGGGCAAGTTGAT	0.567000													12	58					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066852	46066852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46066852C>T	ENST00000334670.8	+	1	522	c.477C>T	c.(475-477)tcC>tcT	p.S159S	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	153	25 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						GCTGTGTGTCCACCTGCTCTG	0.637000													57	225					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62329911	62329911	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62329911G>A	ENST00000371158.2	+	20	2555	c.2439_splice	c.e20-1	p.G814_splice	INADL_ENST00000316485.6_Splice_Site_p.G814_splice	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	814					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TATTTATAGGGATTTAGAGAT	0.358000													11	71					0	0	1	0	0
SLC35F2	54733	broad.mit.edu	37	11	107673741	107673741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:107673741G>A	ENST00000525071.1	-	10	1513	c.925C>T	c.(925-927)Ctg>Ttg	p.L309L	SLC35F2_ENST00000375682.4_Silent_p.L262L|SLC35F2_ENST00000429869.1_Silent_p.L309L|SLC35F2_ENST00000265836.7_Silent_p.L161L|SLC35F2_ENST00000525815.1_Silent_p.L309L			Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	309					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		TAGCCAAACAGAAAGAGTCCA	0.413000													22	58					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68903887	68903887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:68903887G>A	ENST00000262340.5	-	10	1164	c.1111C>T	c.(1111-1113)Cct>Tct	p.P371S		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	371					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						ATATTCAAAGGAAGTACATAT	0.373000													20	45					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202010	140202010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140202010G>A	ENST00000529859.1	+	1	650	c.650G>A	c.(649-651)gGa>gAa	p.G217E	PCDHA5_ENST00000529619.1_Missense_Mutation_p.G217E|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.G217E|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGATGGAGGAAAACCCGAA	0.358000													46	125					0	0	1	0	0
RASA4	10156	broad.mit.edu	37	7	102246372	102246372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:102246372G>A	ENST00000262940.7	-	5	428	c.361C>T	c.(361-363)Cac>Tac	p.H121Y	RP11-514P8.6_ENST00000519541.1_3'UTR|RASA4_ENST00000461209.1_Missense_Mutation_p.H49Y|RASA4_ENST00000449970.2_Missense_Mutation_p.H121Y|RASA4_ENST00000462172.1_Missense_Mutation_p.H49Y	NM_006989.5	NP_008920.5	O43374	RASL2_HUMAN	RAS p21 protein activator 4	121					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytosol|intrinsic to internal side of plasma membrane	metal ion binding|Ras GTPase activator activity			lung(1)|prostate(1)|urinary_tract(1)	3						AGCCGCAGGTGGATCTCGCCC	0.716000													12	24					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332600	71332600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71332600C>T	ENST00000242462.4	-	2	229	c.200G>A	c.(199-201)gGa>gAa	p.G67E		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	67					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						CCGGCTGCGTCCCCCGCGCCG	0.697000													4	9					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215807904	215807904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215807904C>T	ENST00000366943.2	-	70	15580	c.15194G>A	c.(15193-15195)aGa>aAa	p.R5065K	USH2A_ENST00000307340.3_Missense_Mutation_p.R5065K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5065					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGGATTTTTCTTTGTAGTAT	0.448000										HNSCC(13;0.011)			24	75					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51220090	51220090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51220090G>A	ENST00000293441.1	-	1	105	c.87C>T	c.(85-87)tcC>tcT	p.S29S	SHANK1_ENST00000359082.3_Silent_p.S29S|SHANK1_ENST00000391814.1_Silent_p.S29S	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	29					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCCCGTCTGGGGAGCTGTCGG	0.711000													10	6					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51649346	51649346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51649346C>T	ENST00000317643.6	+	4	1064	c.995C>T	c.(994-996)tCc>tTc	p.S332F	SIGLEC7_ENST00000600577.1_Intron|SIGLEC7_ENST00000305628.7_Missense_Mutation_p.S239F	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	332	Ig-like C2-type 2.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CAGCACGTTTCCCTGAACCTC	0.607000													25	61					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6013256	6013256	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:6013256G>A	ENST00000259569.5	-	1	2362	c.2352C>T	c.(2350-2352)tcC>tcT	p.S784S		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	784					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TAACTTCAATGGACTTTGCAA	0.388000													66	81					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57754021	57754021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57754021G>A	ENST00000281282.5	+	8	2412	c.2334G>A	c.(2332-2334)atG>atA	p.M778I		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	778						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		ATCAGGAGATGGACAAGCTGA	0.537000													26	69					0	0	1	0	0
TRAV9-2	28677	broad.mit.edu	37	14	22409569	22409569	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22409569G>A	ENST00000390441.2	+	0	115																											AGAACCCGTGGAAATTCAGTG	0.448000													4	9					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130283963	130283963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130283963G>A	ENST00000358511.6	+	3	818	c.787G>A	c.(787-789)Gaa>Aaa	p.E263K	COL6A6_ENST00000453409.2_Missense_Mutation_p.E263K	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	263	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TGACATAAAGGAAAATTGCAT	0.393000													35	128					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64397937	64397937	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64397937G>A	ENST00000265459.6	-	19	4155	c.3694C>T	c.(3694-3696)Cga>Tga	p.R1232*	NRXN2_ENST00000377551.1_Nonsense_Mutation_p.R1232*|NRXN2_ENST00000409571.1_Nonsense_Mutation_p.R1225*|NRXN2_ENST00000377559.3_Nonsense_Mutation_p.R1192*|NRXN2_ENST00000301894.2_Nonsense_Mutation_p.R186*	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1232	Laminin G-like 6.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CCGCCGCTTCGAGTGAAGCGC	0.672000													27	84					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157497642	157497642	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157497642G>A	ENST00000361835.3	-	9	1882	c.1725C>T	c.(1723-1725)gcC>gcT	p.A575A	FCRL5_ENST00000368190.3_Silent_p.A575A|FCRL5_ENST00000356953.4_Silent_p.A575A|FCRL5_ENST00000368191.3_Silent_p.A490A	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	575	Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CCACAGCCTGGGCCCTGGGAA	0.532000													33	106					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158974352	158974352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158974352C>T	ENST00000605860.1	+	7	573	c.527C>T	c.(526-528)cCc>cTc	p.P176L	UPP2_ENST00000460456.1_Intron|UPP2_ENST00000005756.4_Missense_Mutation_p.P119L|UPP2_ENST00000409859.4_Missense_Mutation_p.P176L			O95045	UPP2_HUMAN	uridine phosphorylase 2	119					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						ATGGGCATCCCCTCCATTTCT	0.408000													12	102					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38862636	38862636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38862636G>A	ENST00000359357.3	+	57	8346	c.8092G>A	c.(8092-8094)Gac>Aac	p.D2698N	DNAH8_ENST00000441566.1_Missense_Mutation_p.D2662N|DNAH8_ENST00000449981.2_Missense_Mutation_p.D2915N					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGTAATTGCAGACAGGTGCGT	0.398000													11	16					0	0	1	0	0
ODF1	4956	broad.mit.edu	37	8	103564043	103564043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:103564043G>A	ENST00000285402.3	+	1	244	c.88G>A	c.(88-90)Gaa>Aaa	p.E30K		NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	30					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			ATGCATCGACGAATTTAGCAC	0.493000													53	143					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22255652	22255652	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22255652G>A	ENST00000594947.1	+	2	189	c.45G>A	c.(43-45)ctG>ctA	p.L15L	ZNF257_ENST00000600162.1_Silent_p.L15L	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	15	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				AATTCTCTCTGGAGGAGTGGC	0.433000													50	160					0	0	1	0	0
YTHDC2	64848	broad.mit.edu	37	5	112929053	112929053	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:112929053C>A	ENST00000161863.4	+	29	4479	c.4266C>A	c.(4264-4266)ccC>ccA	p.P1422P		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1422							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AACGTCTTCCCTTGGGAGAAA	0.368000													24	64					4.7796e-09	4.79703e-09	1	1	0
CAPN9	10753	broad.mit.edu	37	1	230916261	230916261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230916261G>A	ENST00000354537.1	+	10	1292	c.1210G>A	c.(1210-1212)Gaa>Aaa	p.E404K	RP11-99J16__A.2_ENST00000452640.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA|CAPN9_ENST00000366666.2_Missense_Mutation_p.E367K|RP11-99J16__A.2_ENST00000428480.1_RNA|CAPN9_ENST00000271971.2_Missense_Mutation_p.E430K	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	430	Domain III.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TGACAAAGACGAACACCTGAA	0.517000													32	83					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40300277	40300277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40300277C>T	ENST00000263791.5	+	25	3500	c.3457C>T	c.(3457-3459)Ccc>Tcc	p.P1153S	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.P1125S|EIF2AK4_ENST00000559311.1_3'UTR	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1153	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCGATTTCATCCCAAAGAACT	0.408000													54	185					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15262412	15262412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15262412C>T	ENST00000256953.2	-	5	568	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	RERG_ENST00000546331.1_Missense_Mutation_p.E59K|RERG_ENST00000538313.1_Missense_Mutation_p.E78K|RERG_ENST00000536465.1_Missense_Mutation_p.E78K	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	78					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						ACAAAGCCTTCCCCCCATCGC	0.458000													51	464					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52502448	52502448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:52502448C>T	ENST00000219746.9	-	2	410	c.126G>A	c.(124-126)gcG>gcA	p.A42A	TOX3_ENST00000407228.3_Silent_p.A38A	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	42					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						ACGCATTGTTCGCCTCAGCCA	0.353000													26	98					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69959346	69959346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:69959346C>T	ENST00000359154.2	+	11	1294	c.1193C>T	c.(1192-1194)tCg>tTg	p.S398L	WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000568684.1_5'UTR|WWP2_ENST00000542271.1_Missense_Mutation_p.S282L|WWP2_ENST00000448661.1_Missense_Mutation_p.S398L|WWP2_ENST00000356003.2_Missense_Mutation_p.S398L	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	398					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity	p.S398L(1)		breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCGAGTGCTTCGACTGACCAT	0.488000													182	397					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38627445	38627445	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38627445G>A	ENST00000413689.1	-	16	2717	c.2524C>T	c.(2524-2526)Ctg>Ttg	p.L842L	SCN5A_ENST00000423572.2_Silent_p.L842L|SCN5A_ENST00000425664.1_Silent_p.L842L|SCN5A_ENST00000333535.4_Silent_p.L842L|SCN5A_ENST00000451551.2_Silent_p.L842L|SCN5A_ENST00000455624.2_Silent_p.L842L|SCN5A_ENST00000449557.2_Silent_p.L842L|SCN5A_ENST00000450102.2_Silent_p.L842L|SCN5A_ENST00000443581.1_Silent_p.L842L|SCN5A_ENST00000414099.2_Silent_p.L842L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	842					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACCAGTGTCAGGTTCCCCAGT	0.572000													30	63					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70303932	70303932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70303932G>A	ENST00000310961.5	+	8	932	c.514G>A	c.(514-516)Gag>Aag	p.E172K	LRRC7_ENST00000035383.5_Missense_Mutation_p.E167K|LRRC7_ENST00000370958.1_Missense_Mutation_p.E205K|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	167						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GCGGATCTTGGAGTTAAGAGA	0.289000													8	45					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13397765	13397765	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13397765G>T	ENST00000360228.5	-	20	3104	c.3105C>A	c.(3103-3105)tcC>tcA	p.S1035S	CACNA1A_ENST00000573710.2_Silent_p.S1036S	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1036					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CAGGGACCCCGGAGCCCTGGT	0.537000													18	16					2.94398e-08	2.9536e-08	1	1	0
C16orf62	57020	broad.mit.edu	37	16	19580865	19580865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19580865C>T	ENST00000438132.3	+	3	552	c.504C>T	c.(502-504)ctC>ctT	p.L168L	C16orf62_ENST00000251143.5_Silent_p.L79L|C16orf62_ENST00000417362.2_Silent_p.L79L|C16orf62_ENST00000542263.1_Silent_p.L168L|C16orf62_ENST00000538853.1_Silent_p.L168L	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	79				F -> S (in Ref. 3; CAH10399).		integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						CTGACCCCCTCTCCATGTTTG	0.612000													7	50					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77406534	77406534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77406534G>A	ENST00000560626.2	-	7	5680	c.5205C>T	c.(5203-5205)tcC>tcT	p.S1735S	PEAK1_ENST00000312493.4_Silent_p.S1735S			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1735					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TACAACTGAGGGAGTCTGTAG	0.463000													28	127					0	0	1	0	0
EGR2	1959	broad.mit.edu	37	10	64573977	64573977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:64573977G>A	ENST00000242480.3	-	2	746	c.421C>T	c.(421-423)Ccc>Tcc	p.P141S	EGR2_ENST00000411732.1_Missense_Mutation_p.P91S|EGR2_ENST00000439032.1_Missense_Mutation_p.P141S	NM_000399.3|NM_001136177.1	NP_000390.2|NP_001129649.1	P11161	EGR2_HUMAN	early growth response 2	141					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	36	Prostate(12;0.0297)|all_hematologic(501;0.228)					AGTGGGTTGGGGGAGGCAGAG	0.597000													15	61					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121384967	121384967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121384967C>T	ENST00000260197.7	+	8	1277	c.1148C>T	c.(1147-1149)tCc>tTc	p.S383F	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	383					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CTGAAGTTCTCCCTGTCCTTG	0.542000													19	62					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154681001	154681001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:154681001G>A	ENST00000404039.1	+	24	2719	c.2132G>A	c.(2131-2133)cGa>cAa	p.R711Q	DPP6_ENST00000427557.1_Missense_Mutation_p.R668Q|DPP6_ENST00000377770.3_Missense_Mutation_p.R775Q|DPP6_ENST00000332007.3_Missense_Mutation_p.R713Q	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	775					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GTAGCCCATCGAGTCTCCGCG	0.542000													9	31					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19592859	19592859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19592859G>A	ENST00000438132.3	+	7	838	c.790G>A	c.(790-792)Gag>Aag	p.E264K	C16orf62_ENST00000251143.5_Missense_Mutation_p.E175K|C16orf62_ENST00000448695.1_Missense_Mutation_p.E53K|C16orf62_ENST00000417362.2_Missense_Mutation_p.E175K|C16orf62_ENST00000542263.1_Missense_Mutation_p.E264K|C16orf62_ENST00000543152.1_5'UTR|C16orf62_ENST00000538853.1_3'UTR	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	175						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						TTCCCAAAAGGAGCTGTTGAA	0.493000													39	157					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19428056	19428056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19428056G>A	ENST00000375267.2	-	88	12984	c.12981C>T	c.(12979-12981)acC>acT	p.T4327T	UBR4_ENST00000543981.1_Silent_p.T18T|UBR4_ENST00000375226.2_Silent_p.T4303T|UBR4_ENST00000375224.1_Silent_p.T34T|UBR4_ENST00000375254.3_Silent_p.T4327T|UBR4_ENST00000375217.2_Silent_p.T4320T			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	4327					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGAACACCGGGGTCCGGTAGT	0.537000													27	120					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12186665	12186665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12186665G>A	ENST00000439326.3	+	4	905	c.730G>A	c.(730-732)Gaa>Aaa	p.E244K	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	244					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TCAAATACATGAAAGAACTCA	0.373000													9	35					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98850360	98850360	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:98850360G>A	ENST00000554295.1	-	0	563					NR_033801.1																						CCTATGGGTCGAATGTTACCT	0.413000													8	22					0	0	1	0	0
TM4SF18	116441	broad.mit.edu	37	3	149040164	149040164	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:149040164C>T	ENST00000296059.2	-	5	735	c.470G>A	c.(469-471)tGg>tAg	p.W157*	TM4SF18_ENST00000470080.1_Nonsense_Mutation_p.W157*|RP11-206M11.7_ENST00000489011.1_RNA	NM_138786.3	NP_620141.1	Q96CE8	T4S18_HUMAN	transmembrane 4 L six family member 18	157						integral to membrane				lung(1)|ovary(1)|prostate(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			AATGATGTTCCACTCCACAAC	0.443000													8	82					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95500992	95500992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95500992C>T	ENST00000297591.5	-	24	5456	c.5381G>A	c.(5380-5382)gGa>gAa	p.G1794E	KIAA1429_ENST00000437199.1_3'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1794					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AACAAACTTTCCTCTTGAGCC	0.498000													67	174					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519592	113519592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113519592C>T	ENST00000284601.3	-	4	1623	c.1555G>A	c.(1555-1557)Gaa>Aaa	p.E519K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	519					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						ATTCTTTGTTCTTCATCATCC	0.333000													9	31					0	0	1	0	0
DEFA6	1671	broad.mit.edu	37	8	6783476	6783476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:6783476G>A	ENST00000297436.2	-	1	122	c.82C>T	c.(82-84)Cca>Tca	p.P28S		NM_001926.3	NP_001917.1	Q01524	DEF6_HUMAN	defensin, alpha 6, Paneth cell-specific	28					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				lung(4)	4			STAD - Stomach adenocarcinoma(24;0.0322)	COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		GCCTGCAGTGGATCATCCTCA	0.577000													10	19					0	0	1	0	0
PNKP	11284	broad.mit.edu	37	19	50370385	50370385	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50370385G>A	ENST00000322344.3	-	2	186	c.77C>T	c.(76-78)tCg>tTg	p.S26L	PNKP_ENST00000596014.1_Missense_Mutation_p.S26L|PNKP_ENST00000600910.1_Missense_Mutation_p.S26L|PNKP_ENST00000595792.1_5'UTR|PNKP_ENST00000600573.1_Missense_Mutation_p.S26L	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	26					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		TTGCCCGTCCGAGGGCAGGAA	0.726000								Other BER factors					13	51					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23019757	23019757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23019757C>T	ENST00000327968.5	+	1	1671	c.1583C>T	c.(1582-1584)tCc>tTc	p.S528F	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	528	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						GATATAGTATCCCGAGGTCTT	0.378000													44	35					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42434764	42434764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42434764G>A	ENST00000397272.3	-	19	2388	c.2297C>T	c.(2296-2298)cCc>cTc	p.P766L	PLA2G4F_ENST00000382396.4_Missense_Mutation_p.P764L	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	764	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GTTAACCAGGGGGAAGTGCAG	0.632000													19	50					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	19018374	19018374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19018374G>A	ENST00000420770.2	+	5	796	c.713G>A	c.(712-714)aGg>aAg	p.R238K	PAX7_ENST00000375375.3_Missense_Mutation_p.R238K|PAX7_ENST00000400661.3_Missense_Mutation_p.R236K	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	238					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		GCCTTTGAGAGGACCCACTAC	0.637000			T	FOXO1A	alveolar rhabdomyosarcoma								7	24					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139216801	139216801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139216801G>A	ENST00000274710.3	+	11	1848	c.1643G>A	c.(1642-1644)gGg>gAg	p.G548E		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	548	PH.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCTCAAAGGGACCATCCTG	0.622000													34	66					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31256287	31256287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:31256287C>T	ENST00000407793.2	+	25	2740	c.2489C>T	c.(2488-2490)tCt>tTt	p.S830F	DDX11_ENST00000542838.1_Silent_p.L832L|DDX11_ENST00000350437.4_Silent_p.L782L|DDX11_ENST00000251758.5_3'UTR|DDX11_ENST00000228264.6_Silent_p.L806L|DDX11_ENST00000545668.1_Missense_Mutation_p.S830F	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	830					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					AGGGAAGGCTCTGGTGGAGAA	0.637000										Multiple Myeloma(12;0.14)			8	18					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62286062	62286062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62286062G>A	ENST00000378024.4	-	5	16101	c.15827C>T	c.(15826-15828)cCc>cTc	p.P5276L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5276					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AGAAACATCGGGCCCTTCGAG	0.532000													20	69					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237936946	237936946	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237936946C>T	ENST00000366574.2	+	87	12090	c.11773C>T	c.(11773-11775)Cag>Tag	p.Q3925*	RYR2_ENST00000542537.1_Nonsense_Mutation_p.Q3909*|RYR2_ENST00000360064.6_Nonsense_Mutation_p.Q3931*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3925					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGAGTATATTCAGGTAAACAT	0.368000													12	24					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77387698	77387698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77387698C>T	ENST00000282849.5	-	10	1964	c.1546G>A	c.(1546-1548)Gat>Aat	p.D516N		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	516	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GTGTCAGCATCATAAATCTGT	0.428000													45	121					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756444	94756444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94756444C>T	ENST00000554723.1	-	2	1025	c.607G>A	c.(607-609)Ggg>Agg	p.G203R	SERPINA10_ENST00000554173.1_Missense_Mutation_p.G163R|SERPINA10_ENST00000393096.1_Missense_Mutation_p.G163R|SERPINA10_ENST00000261994.4_Missense_Mutation_p.G163R			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	163					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		GCAAAACTCCCCTGTGTGAGG	0.507000													34	82					0	0	1	0	0
KLK7	5650	broad.mit.edu	37	19	51485632	51485632	+	Silent	SNP	G	G	A	rs113100315		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51485632G>A	ENST00000391807.1	-	2	125	c.24C>T	c.(22-24)ccC>ccT	p.P8P	KLK7_ENST00000595638.1_5'UTR|KLK7_ENST00000595820.1_Silent_p.P8P|CTB-147C22.9_ENST00000594512.1_RNA|KLK7_ENST00000336317.4_5'UTR|KLK7_ENST00000597707.1_Intron	NM_139277.2	NP_644806.1	P49862	KLK7_HUMAN	kallikrein-related peptidase 7	8					epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(2)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		AGATCTGCAGGGGCAGGAGAA	0.592000													4	9					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96937826	96937826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96937826G>A	ENST00000267584.4	+	13	1413	c.1369G>A	c.(1369-1371)Gat>Aat	p.D457N		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	457	Adenylate kinase.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TCAACTAGACGATCAATATAT	0.279000													10	62					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4525711	4525711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4525711C>T	ENST00000381848.3	-	6	734	c.654G>A	c.(652-654)ggG>ggA	p.G218G		NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	218						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						GCCTCAGTTTCCCCACAGAGT	0.662000													34	68					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325004	150325004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150325004C>T	ENST00000328902.5	-	3	898	c.682G>A	c.(682-684)Gga>Aga	p.G228R	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	228							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TAATAATCTCCTTCGTTTTCC	0.512000													70	176					0	0	1	0	0
OXGR1	27199	broad.mit.edu	37	13	97639219	97639219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:97639219G>A	ENST00000298440.1	-	4	1038	c.795C>T	c.(793-795)atC>atT	p.I265I	OXGR1_ENST00000543457.1_Silent_p.I265I	NM_080818.3	NP_543008.3	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	265						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			NS(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			GGCGAGATTCGATCCGAATGA	0.433000													20	69					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10392112	10392112	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10392112G>A	ENST00000397077.1	-	14	2726	c.2151C>T	c.(2149-2151)ttC>ttT	p.F717F	ATP2B2_ENST00000383800.4_Silent_p.F717F|ATP2B2_ENST00000360273.2_Silent_p.F762F|ATP2B2_ENST00000352432.4_Silent_p.F762F|ATP2B2_ENST00000343816.4_Silent_p.F748F			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	762					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						TCCTCCTGTTGAACTCCTTGC	0.592000													32	55					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101551177	101551177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101551177C>T	ENST00000536262.2	-	15	2271	c.1713G>A	c.(1711-1713)aaG>aaA	p.K571K		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	571	Poly-Lys.				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AAACATGCTTCTTCTAAAAGA	0.343000													3	11					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109271289	109271289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109271289G>A	ENST00000370017.3	+	8	1682	c.1405G>A	c.(1405-1407)Gat>Aat	p.D469N	FNDC7_ENST00000271311.2_Missense_Mutation_p.D470N	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	470	Fibronectin type-III 6.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TGTTTCAAGGGATGCATTCTC	0.418000													20	53					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70342950	70342950	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70342950C>T	ENST00000333646.6	+	11	1690	c.1491C>T	c.(1489-1491)tcC>tcT	p.S497S	MED12_ENST00000374102.1_Silent_p.S497S|MED12_ENST00000374080.3_Silent_p.S497S	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	497					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TCCAGATCTCCTCAGATGATG	0.483000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						82	64					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3654979	3654979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3654979C>T	ENST00000263087.4	-	15	1956	c.1858G>A	c.(1858-1860)Gga>Aga	p.G620R		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	620					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TCCCAGTGTCCATTGTAGATA	0.597000													18	33					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291460	141291460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:141291460G>A	ENST00000247452.3	-	3	661	c.314C>T	c.(313-315)tCc>tTc	p.S105F		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	105	Ser-rich.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TGAAAAAGAGGAGCAGCAGGA	0.557000										HNSCC(46;0.14)			26	26					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71068757	71068757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:71068757G>A	ENST00000452400.2	-	11	2024	c.1843C>T	c.(1843-1845)Ccc>Tcc	p.P615S	NCOA2_ENST00000524223.1_5'UTR	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	615					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GGCAGGTTGGGGTCATTTGTT	0.552000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								26	94					0	0	1	0	0
DTX3	196403	broad.mit.edu	37	12	58000757	58000757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58000757G>A	ENST00000548198.1	+	3	1615	c.111G>A	c.(109-111)ctG>ctA	p.L37L	DTX3_ENST00000548804.1_Silent_p.L37L|DTX3_ENST00000551632.1_Silent_p.L40L|DTX3_ENST00000337737.3_Silent_p.L37L			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	37					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					CAGCCCGGCTGGCCCGGCTTC	0.607000													47	330					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62192276	62192276	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62192276G>A	ENST00000467148.1	-	15	7222	c.7153C>T	c.(7153-7155)Ctt>Ttt	p.L2385F	HELZ2_ENST00000427522.2_Missense_Mutation_p.L1816F	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		TCTCCGAGAAGAACCACCTGG	0.642000													17	99					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	598008	598008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:598008C>T	ENST00000219611.2	+	4	1533	c.1170C>T	c.(1168-1170)agC>agT	p.S390S	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		ACAAGCCCAGCCCCTGCGGCA	0.746000													3	8					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203667416	203667416	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203667416C>T	ENST00000357681.5	+	3	1448	c.325C>T	c.(325-327)Ctg>Ttg	p.L109L	ATP2B4_ENST00000391954.2_Silent_p.L109L|ATP2B4_ENST00000367219.3_Silent_p.L109L|ATP2B4_ENST00000341360.2_Silent_p.L109L|ATP2B4_ENST00000367218.3_Silent_p.L109L	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	109					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GCTTATCATCCTGGAGATTGC	0.483000													32	104					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45968358	45968358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45968358G>A	ENST00000260324.7	+	6	1100	c.714G>A	c.(712-714)ggG>ggA	p.G238G	RP11-96O20.4_ENST00000564080.1_Silent_p.G238G|SQRDL_ENST00000568606.1_Silent_p.G238G	NM_021199.2	NP_067022.1	Q9Y6N5	SQRD_HUMAN	sulfide quinone reductase-like (yeast)	238							oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	11		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		CCATTTTCGGGGTTAAGAAGT	0.443000													95	191					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42489109	42489109	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42489109G>A	ENST00000545399.1	-	8	1146	c.993C>T	c.(991-993)atC>atT	p.I331I	ATP1A3_ENST00000302102.5_Silent_p.I318I|ATP1A3_ENST00000602133.1_Silent_p.I288I|ATP1A3_ENST00000543770.1_Silent_p.I329I	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	318					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CATTGGCCACGATGATGCCGA	0.612000													8	26					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	410451	410451	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:410451G>A	ENST00000280886.6	-	20	2427	c.2340C>T	c.(2338-2340)ttC>ttT	p.F780F	DIP2C_ENST00000381496.3_3'UTR|DIP2C_ENST00000540204.1_Silent_p.F101F	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	780						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CGGGACCCACGAACCCCAGCA	0.617000													19	65					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103067330	103067330	+	Silent	SNP	C	C	T	rs140183707	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103067330C>T	ENST00000264260.2	+	11	1822	c.1233C>T	c.(1231-1233)ttC>ttT	p.F411F	IL18RAP_ENST00000409369.1_Silent_p.F269F	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	411	TIR.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity	p.F411F(1)		autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TTGATGCTTTCGTATCCTATG	0.343000													36	78					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663768	169663768	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169663768C>T	ENST00000483289.2	-	0	3526				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						TGGCCAGATTCACAGAGCATT	0.498000													12	152					0	0	1	0	0
OPHN1	4983	broad.mit.edu	37	X	67502952	67502952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:67502952G>A	ENST00000355520.5	-	4	899	c.258C>T	c.(256-258)tcC>tcT	p.S86S	OPHN1_ENST00000540071.1_Silent_p.S86S	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	86					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						ATTCCTTGAAGGATTCAGCTG	0.413000													17	21					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56380414	56380414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56380414G>A	ENST00000370754.5	-	72	18316	c.18317C>T	c.(18316-18318)tCa>tTa	p.S6106L	DST_ENST00000370788.2_Missense_Mutation_p.S3731L|DST_ENST00000361203.3_Missense_Mutation_p.S5817L|DST_ENST00000421834.2_Missense_Mutation_p.S3840L|DST_ENST00000446842.2_Missense_Mutation_p.S5602L|DST_ENST00000370769.4_Missense_Mutation_p.S5928L|DST_ENST00000312431.6_3'UTR|DST_ENST00000340834.4_5'UTR|DST_ENST00000244364.6_Missense_Mutation_p.S3514L			Q03001	DYST_HUMAN	dystonin	5926					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATACCTTTCTGAATTAATCTG	0.418000													5	35					0	0	1	0	0
FRRS1L	23732	broad.mit.edu	37	9	111911944	111911944	+	Missense_Mutation	SNP	C	C	T	rs141125474	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111911944C>T	ENST00000374581.3	-	2	447	c.448G>A	c.(448-450)Gac>Aac	p.D150N		NM_014334.2	NP_055149.2	Q9P0K9	CI004_HUMAN	ferric-chelate reductase 1-like	150						integral to membrane											TTTCCACAGTCGTCCACTTTG	0.428000													4	38					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159646591	159646591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159646591G>A	ENST00000297267.9	+	8	1109	c.909G>A	c.(907-909)gaG>gaA	p.E303E	FNDC1_ENST00000480856.1_3'UTR|FNDC1_ENST00000340366.6_Silent_p.E303E	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	303	Fibronectin type-III 3.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCTATCGAGAGAAGGGGGAAT	0.468000													58	91					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63533730	63533730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:63533730G>A	ENST00000307078.5	-	6	1737	c.1424C>T	c.(1423-1425)tCg>tTg	p.S475L	AXIN2_ENST00000375702.5_Missense_Mutation_p.S475L	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	475	Interaction with beta-catenin (By similarity).				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						GTGGTACTGCGAATGGTGGTG	0.711000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				3	12					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957827	49957827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:49957827C>T	ENST00000376056.2	-	5	1660	c.1510G>A	c.(1510-1512)Gga>Aga	p.G504R	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000358526.2_Missense_Mutation_p.G513R|AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000376064.3_Missense_Mutation_p.G504R			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	513					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					CATGAGTTTCCTTGCTTTTGG	0.448000													86	53					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084126	152084126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152084126C>T	ENST00000368804.1	-	2	1566	c.1567G>A	c.(1567-1569)Gag>Aag	p.E523K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	523	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTCCTCCTCCTGGCGCTTC	0.652000													44	196					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079149	57079149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57079149G>A	ENST00000316981.3	-	5	1635	c.1156C>T	c.(1156-1158)Cct>Tct	p.P386S	PLAG1_ENST00000429357.2_Missense_Mutation_p.P386S|PLAG1_ENST00000423799.2_Missense_Mutation_p.P304S	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	386	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Massively activates transcription.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			CCAATCTGAGGATCCAACCCT	0.483000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								36	110					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184938	19184938	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:19184938G>A	ENST00000275461.3	-	1	106	c.48C>T	c.(46-48)ttC>ttT	p.F16F	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	16					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						GGTCTGCGACGAAGTCCAGCA	0.672000													17	47					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72993646	72993646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72993646G>A	ENST00000268489.5	-	2	1071	c.399C>T	c.(397-399)atC>atT	p.I133I	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	133					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GCTGGTAGACGATCTCCCCGG	0.711000													17	47					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1221818	1221818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1221818G>A	ENST00000304460.10	+	12	1760	c.1704G>A	c.(1702-1704)gaG>gaA	p.E568E		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	568					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTCCCCAGGAGGAATTTCCCA	0.592000													13	49					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95502186	95502186	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95502186G>A	ENST00000343958.4	-	11	3425	c.3202C>T	c.(3202-3204)Cag>Tag	p.Q1068*	FGD6_ENST00000546711.1_Nonsense_Mutation_p.Q1068*|FGD6_ENST00000549499.1_Nonsense_Mutation_p.Q1068*	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1068					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						ATAAGTTTCTGAAAGTTGTCC	0.423000													11	45					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142565412	142565412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142565412C>T	ENST00000392957.2	+	12	2584	c.1797C>T	c.(1795-1797)tcC>tcT	p.S599S	EPHB6_ENST00000442129.1_Silent_p.S599S|EPHB6_ENST00000411471.2_Silent_p.S322S	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	599						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					TGATCGGCTCCATCCTGGGGG	0.657000													8	14					0	0	1	0	0
CHRM1	1128	broad.mit.edu	37	11	62677322	62677322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62677322G>A	ENST00000306960.3	-	2	1792	c.1251C>T	c.(1249-1251)tgC>tgT	p.C417C	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	417					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	AGAGTGCGTAGCACATGGGGT	0.607000													37	146					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154860085	154860085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:154860085G>A	ENST00000460393.1	+	12	1274	c.1154G>A	c.(1153-1155)cGa>cAa	p.R385Q	MME_ENST00000462745.1_Missense_Mutation_p.R385Q|MME_ENST00000493237.1_Missense_Mutation_p.R385Q|MME_ENST00000492661.1_Missense_Mutation_p.R385Q|MME_ENST00000360490.2_Missense_Mutation_p.R385Q	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	385					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding	p.R385Q(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	AGCCTCAGCCGAACCTACAAG	0.383000													11	108					0	0	1	0	0
KIAA0391	9692	broad.mit.edu	37	14	35649969	35649969	+	Missense_Mutation	SNP	C	C	T	rs147065101		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:35649969C>T	ENST00000557565.1	+	5	1642	c.1261C>T	c.(1261-1263)Cgt>Tgt	p.R421C	KIAA0391_ENST00000534898.4_Missense_Mutation_p.R421C|KIAA0391_ENST00000604948.1_Missense_Mutation_p.R326C|KIAA0391_ENST00000603544.1_Missense_Mutation_p.R405C|KIAA0391_ENST00000250377.7_Missense_Mutation_p.R326C|KIAA0391_ENST00000605870.1_Missense_Mutation_p.R49C|KIAA0391_ENST00000321130.10_Missense_Mutation_p.R405C			O15091	MRRP3_HUMAN	KIAA0391	421					tRNA processing	mitochondrion				central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		TCCTAAAGTTCGTGAATCTCA	0.333000													13	54					0	0	1	0	0
HDAC6	10013	broad.mit.edu	37	X	48666444	48666444	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48666444C>A	ENST00000334136.5	+	9	815	c.637C>A	c.(637-639)Cct>Act	p.P213T	HDAC6_ENST00000444343.2_Missense_Mutation_p.P227T|HDAC6_ENST00000469223.1_3'UTR|HDAC6_ENST00000376619.2_Missense_Mutation_p.P213T|HDAC6_ENST00000413163.2_Missense_Mutation_p.P158T			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	213	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	GCCCAGGCCTCCTGGACATCA	0.547000													5	7					0.000602214	0.000602896	1	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28304412	28304412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:28304412G>A	ENST00000284987.5	-	6	2081	c.1960C>T	c.(1960-1962)Ccc>Tcc	p.P654S	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	654	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						GCATATTTGGGAACCCATTCC	0.448000													46	24					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93142930	93142930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93142930C>T	ENST00000216487.7	+	8	2605	c.2446C>T	c.(2446-2448)Ccc>Tcc	p.P816S	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	816	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				GCTCATGGACCCCGCCCTGCA	0.622000													12	52					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467747	10467747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10467747C>T	ENST00000382483.3	-	4	4084	c.3861G>A	c.(3859-3861)tcG>tcA	p.S1287S		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1287					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GCTCCAGGTTCGAGCTCGCCC	0.522000													21	174					0	0	1	0	0
ZNF555	148254	broad.mit.edu	37	19	2853194	2853194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2853194C>T	ENST00000334241.4	+	4	1269	c.1131C>T	c.(1129-1131)ttC>ttT	p.F377F	AC006130.3_ENST00000589365.1_RNA|ZNF555_ENST00000591539.1_Silent_p.F376F	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGACCTTCATTTATCCCC	0.463000													11	42					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85950141	85950141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:85950141C>T	ENST00000373131.1	+	4	1014	c.851C>T	c.(850-852)cCa>cTa	p.P284L	DACH2_ENST00000508860.1_Missense_Mutation_p.P130L|DACH2_ENST00000373125.4_Missense_Mutation_p.P297L|DACH2_ENST00000510272.1_Missense_Mutation_p.P78L	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding	p.P284Q(1)|p.P297Q(1)		breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						GGGGGTGCTCCAACCCTCAAT	0.493000													11	6					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60375621	60375621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60375621G>A	ENST00000371204.3	-	5	739	c.696C>T	c.(694-696)gtC>gtT	p.V232V	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	232					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					TCCATGGAAAGACATTGTAGA	0.358000													13	31					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154624199	154624199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:154624199C>T	ENST00000260010.6	+	1	1548	c.140C>T	c.(139-141)cCc>cTc	p.P47L		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	47					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				AACTCCATTCCCTCAGGGCTC	0.493000													15	24					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230252982	230252982	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230252982G>A	ENST00000341772.4	-	11	1988	c.1855_splice	c.e11+1	p.I618_splice		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	618					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AATACTTACGGATCTCACAGT	0.493000													41	117					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54429267	54429267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54429267G>A	ENST00000334206.5	-	6	846	c.670C>T	c.(670-672)Cat>Tat	p.H224Y	CDC20B_ENST00000381375.2_Missense_Mutation_p.H224Y|CDC20B_ENST00000322374.6_Missense_Mutation_p.H224Y|CDC20B_ENST00000296733.1_Missense_Mutation_p.H224Y			Q86Y33	CD20B_HUMAN	cell division cycle 20B	224										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			CCAGTAATATGAATCTTCACC	0.363000													31	109					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61621019	61621019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61621019C>T	ENST00000583023.1	+	10	2242	c.2231C>T	c.(2230-2232)tCa>tTa	p.S744L	KCNH6_ENST00000581784.1_Missense_Mutation_p.S691L|KCNH6_ENST00000456941.2_Missense_Mutation_p.S691L|KCNH6_ENST00000314672.5_Missense_Mutation_p.S744L	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	744					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GACAACCAGTCAGGTGAGCAA	0.647000													28	62					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230272018	230272018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230272018G>A	ENST00000341772.4	-	10	1787	c.1653C>T	c.(1651-1653)agC>agT	p.S551S		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	551	EGF-like 9.|Follistatin-like.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CGTTCAGACAGCTGACGTTAG	0.532000													43	104					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6947245	6947245	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6947245G>A	ENST00000389658.3	-	61	8854	c.8761C>T	c.(8761-8763)Cga>Tga	p.R2921*		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2921	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGGAGGTTCGAAACTCCAGT	0.562000													23	57					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208218536	208218536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:208218536G>A	ENST00000367033.3	-	19	4272	c.3515C>T	c.(3514-3516)cCt>cTt	p.P1172L		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1172	IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TCCAGAGGCAGGAGGGCAGAG	0.493000													30	88					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79572069	79572069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:79572069G>A	ENST00000372391.2	-	21	4097	c.4092C>T	c.(4090-4092)atC>atT	p.I1364I	DLG5_ENST00000372388.2_Silent_p.I1024I|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1364	PDZ 3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTCCACTCACGATGGAGATGC	0.587000													18	73					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36303772	36303772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36303772C>T	ENST00000301175.3	-	2	181	c.164G>A	c.(163-165)gGg>gAg	p.G55E		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	55					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CACCAACTGCCCCTTGCCCAG	0.557000													7	21					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267772	71267772	+	Silent	SNP	G	G	A	rs147891121	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:71267772G>A	ENST00000554752.2	-	2	431	c.432C>T	c.(430-432)ctC>ctT	p.L144L	MAP3K9_ENST00000555993.2_Silent_p.L144L|MAP3K9_ENST00000381250.4_Silent_p.L144L			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	144	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CTTCCAAGGTGAGCTCCGCAA	0.438000													24	63					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61949961	61949961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61949961C>T	ENST00000336844.5	-	4	583	c.432G>A	c.(430-432)gaG>gaA	p.E144E	CSH2_ENST00000392886.2_Silent_p.E144E|CSH2_ENST00000345366.7_Intron|CSH2_ENST00000560142.1_Silent_p.E87E	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	144					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						GGATGCCTTCCTCTAGGTCCT	0.602000													28	101					0	0	1	0	0
KRT39	390792	broad.mit.edu	37	17	39116746	39116746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39116746G>A	ENST00000355612.2	-	6	1039	c.1004C>T	c.(1003-1005)tCc>tTc	p.S335F	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	335	Coil 2.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				GCACTCTTGGGAATCTCTCTA	0.463000													24	85					0	0	1	0	0
SEMA4C	54910	broad.mit.edu	37	2	97527522	97527522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97527522G>A	ENST00000305476.5	-	13	1685	c.1553C>T	c.(1552-1554)gCc>gTc	p.A518V		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	518	PSI.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						GACGCTCCAGGCGCAATAGGG	0.647000													17	64					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66259201	66259201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66259201C>T	ENST00000532677.1	+	9	1420	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	DPP3_ENST00000541961.1_Missense_Mutation_p.P321L|DPP3_ENST00000531863.1_Missense_Mutation_p.P341L|DPP3_ENST00000360510.2_Missense_Mutation_p.P321L|DPP3_ENST00000530165.1_Missense_Mutation_p.P291L|DPP3_ENST00000453114.1_Missense_Mutation_p.P321L	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	321					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TACCGCGACCCCTTTGGTTCC	0.612000													88	197					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120369247	120369247	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120369247A>T	ENST00000602047.1	+	14	1494	c.382A>T	c.(382-384)Att>Ttt	p.I128F	PCDP1_ENST00000413369.3_Missense_Mutation_p.I414F|PCDP1_ENST00000597189.1_3'UTR			Q4G0U5	PCDP1_HUMAN		414						cilium	calmodulin binding					Colorectal(110;0.196)					AGGAGATCCTATTTTGGATGA	0.333000													28	72					0	0	1	0	0
PDGFRL	5157	broad.mit.edu	37	8	17447105	17447105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17447105C>T	ENST00000541323.1	+	3	629	c.184C>T	c.(184-186)Cca>Tca	p.P62S	PDGFRL_ENST00000398074.3_Missense_Mutation_p.P62S|PDGFRL_ENST00000251630.6_Missense_Mutation_p.P62S	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	62	Ig-like C2-type 1.					extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		CAATTCAGCACCAAAGACGCA	0.498000													23	112					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13885322	13885322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13885322C>T	ENST00000265104.4	-	19	2863	c.2759G>A	c.(2758-2760)gGa>gAa	p.G920E	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	920	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTCAAAATTTCCTTCTTCTCT	0.383000									Kartagener syndrome				22	42					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94847393	94847393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94847393C>T	ENST00000448921.1	-	5	1304	c.732G>A	c.(730-732)atG>atA	p.M244I	SERPINA1_ENST00000393088.4_Missense_Mutation_p.M244I|SERPINA1_ENST00000437397.1_Missense_Mutation_p.M244I|SERPINA1_ENST00000355814.4_Missense_Mutation_p.M244I|SERPINA1_ENST00000404814.4_Missense_Mutation_p.M244I|SERPINA1_ENST00000393087.4_Missense_Mutation_p.M244I|SERPINA1_ENST00000402629.1_Missense_Mutation_p.M244I|SERPINA1_ENST00000449399.3_Missense_Mutation_p.M244I|SERPINA1_ENST00000440909.1_Missense_Mutation_p.M244I	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	244					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	AACGCTTCATCATAGGCACCT	0.532000													9	58					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	72941367	72941367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:72941367G>A	ENST00000553530.1	+	10	860	c.653G>A	c.(652-654)cGa>cAa	p.R218Q	RGS6_ENST00000554782.1_Missense_Mutation_p.R79Q|RGS6_ENST00000434263.2_Missense_Mutation_p.R149Q|RGS6_ENST00000556437.1_Missense_Mutation_p.R218Q|RGS6_ENST00000343854.6_Missense_Mutation_p.R218Q|RGS6_ENST00000402788.2_Missense_Mutation_p.R218Q|RGS6_ENST00000555571.1_Missense_Mutation_p.R218Q|RGS6_ENST00000406236.4_Missense_Mutation_p.R218Q|RGS6_ENST00000404301.2_Missense_Mutation_p.R218Q|RGS6_ENST00000553525.1_Missense_Mutation_p.R218Q|RGS6_ENST00000355512.6_Missense_Mutation_p.R218Q|RGS6_ENST00000407322.4_Missense_Mutation_p.R218Q	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	218					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		ATGGATATCCGAAAATGTCGA	0.363000													26	51					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3790455	3790455	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3790455G>A	ENST00000262367.5	-	24	4887	c.4078C>T	c.(4078-4080)Cga>Tga	p.R1360*	CREBBP_ENST00000382070.3_Nonsense_Mutation_p.R1322*	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1360	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.R1360*(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCCACCACTCGGACAAAAACC	0.582000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						7	65					0	0	1	0	0
PSAP	5660	broad.mit.edu	37	10	73591668	73591668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73591668G>A	ENST00000394936.3	-	3	331	c.184C>T	c.(184-186)Ccc>Tcc	p.P62S	PSAP_ENST00000394934.1_Missense_Mutation_p.P62S			P07602	SAP_HUMAN	prosaposin	62	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						ATGTCGCAGGGAAGGGATTTC	0.502000													47	123					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33704144	33704144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33704144C>T	ENST00000336934.5	-	5	786	c.670G>A	c.(670-672)Gat>Aat	p.D224N	STARD13_ENST00000255486.4_Missense_Mutation_p.D216N|STARD13_ENST00000399365.3_Missense_Mutation_p.D106N	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	224					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AGTGGGGCATCCAGCATGACC	0.632000													18	36					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101592065	101592065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101592065G>A	ENST00000284395.5	+	25	3980	c.3580G>A	c.(3580-3582)Gcc>Acc	p.A1194T	LRRK1_ENST00000388948.3_Missense_Mutation_p.A1197T|RP11-505E24.2_ENST00000559857.1_RNA			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1197					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTCCTGACGGCCATCGAGCG	0.637000													7	68					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50666819	50666819	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:50666819C>T	ENST00000371824.1	+	7	1327	c.1070C>T	c.(1069-1071)tCc>tTc	p.S357F	ELAVL4_ENST00000357083.4_Missense_Mutation_p.S374F|ELAVL4_ENST00000371823.4_Missense_Mutation_p.S371F|ELAVL4_ENST00000371821.1_Missense_Mutation_p.S376F|ELAVL4_ENST00000448907.2_Missense_Mutation_p.S360F|ELAVL4_ENST00000371819.1_Missense_Mutation_p.S362F|ELAVL4_ENST00000371827.1_Missense_Mutation_p.S357F			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	371	RRM 3.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						TTGCAAGTTTCCTTTAAAACC	0.458000													20	62					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104679800	104679800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104679800C>T	ENST00000369878.3	+	1	1687	c.1563C>T	c.(1561-1563)ccC>ccT	p.P521P	CNNM2_ENST00000369875.3_Silent_p.P521P|CNNM2_ENST00000433628.2_Silent_p.P521P|CNNM2_ENST00000457502.2_Silent_p.P279P	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	521	CBS 2.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ATAACCACCCCTTGCACTTTG	0.448000													64	145					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55044017	55044017	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55044017G>A	ENST00000335056.3	+	1	41	c.3G>A	c.(1-3)atG>atA	p.M1I																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GTGGCACCATGGCCCCCAAAC	0.507000													51	117					0	0	1	0	0
NR2F1	7025	broad.mit.edu	37	5	92924027	92924027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:92924027G>A	ENST00000327111.3	+	2	2555	c.868G>A	c.(868-870)Gac>Aac	p.D290N		NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	290					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CATGTCTGCCGACCGCGTCGT	0.657000													14	53					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109685438	109685438	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109685438C>T	ENST00000338432.7	+	40	5718	c.5599C>T	c.(5599-5601)Caa>Taa	p.Q1867*	ACACB_ENST00000377848.3_Nonsense_Mutation_p.Q1867*|ACACB_ENST00000377854.5_Nonsense_Mutation_p.Q1797*|ACACB_ENST00000543201.1_Nonsense_Mutation_p.Q533*			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1867	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CCTGACTCCCCAAGACTACAC	0.418000													50	139					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348338	140348338	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348338C>T	ENST00000289269.5	+	1	2519	c.1987C>T	c.(1987-1989)Cga>Tga	p.R663*	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		663	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGTGGTCCGAGATAATGG	0.498000													13	47					0	0	1	0	0
SBK2	646643	broad.mit.edu	37	19	56042656	56042656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56042656G>A	ENST00000413299.1	-	3	347	c.310C>T	c.(310-312)Ctg>Ttg	p.L104L	SBK2_ENST00000344158.3_Silent_p.L104L	NM_001101401.2	NP_001094871.2	P0C263	SBK2_HUMAN	SH3 domain binding kinase family, member 2	104	Protein kinase.						ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						AACTCGTACAGGAAGCCACGG	0.652000													6	14					0	0	1	0	0
SMTNL2	342527	broad.mit.edu	37	17	4500472	4500472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4500472G>A	ENST00000389313.4	+	7	1180	c.1113G>A	c.(1111-1113)gtG>gtA	p.V371V	SMTNL2_ENST00000338859.4_Silent_p.V227V	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	371	CH.									breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		TGCAGCACGTGGACCTGCAGA	0.612000													19	26					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138522699	138522699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138522699G>A	ENST00000440172.1	-	20	5805	c.5757C>T	c.(5755-5757)ctC>ctT	p.L1919L	TMEM213_ENST00000413208.1_Silent_p.R80R|KIAA1549_ENST00000422774.1_Silent_p.L1935L|KIAA1549_ENST00000242365.4_Silent_p.L1869L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1935						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						AGAGCCGGAGGAGCTCCTCGC	0.617000			O	BRAF	pilocytic astrocytoma								13	35					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61465948	61465948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61465948G>A	ENST00000398019.2	+	6	890	c.565G>A	c.(565-567)Gaa>Aaa	p.E189K	SERPINB7_ENST00000336429.2_Missense_Mutation_p.E189K|SERPINB7_ENST00000546027.1_Missense_Mutation_p.E189K|SERPINB7_ENST00000540675.1_Missense_Mutation_p.E172K	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	189					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				CACCAAGAGCGAAACCATAAA	0.423000													40	85					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100155173	100155173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100155173G>A	ENST00000263174.4	+	7	1732	c.1357G>A	c.(1357-1359)Gag>Aag	p.E453K	PALMD_ENST00000605497.1_Missense_Mutation_p.E453K	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	453	Poly-Glu.				regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		TGAGGAGGAGGAGGATGAAGG	0.483000													21	59					0	0	1	0	0
TTC5	91875	broad.mit.edu	37	14	20767011	20767011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20767011G>A	ENST00000258821.3	-	5	640	c.584C>T	c.(583-585)tCt>tTt	p.S195F		NM_138376.2	NP_612385.2	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	195					DNA repair	cytoplasm|nucleus	binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		CTGGCCAGTAGAGAAGTAAAG	0.423000													20	38					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26966471	26966471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26966471G>A	ENST00000528896.2	-	11	1165	c.1091C>T	c.(1090-1092)aCc>aTc	p.T364I	KIAA0100_ENST00000389003.3_Missense_Mutation_p.T221I|KIAA0100_ENST00000544884.1_Missense_Mutation_p.T221I	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	364						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					GAGGTCAATGGTGGTCACCTG	0.453000													25	22					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29012441	29012441	+	Missense_Mutation	SNP	C	C	T	rs55974987	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29012441C>T	ENST00000282397.4	-	4	681	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	FLT1_ENST00000541932.1_Missense_Mutation_p.E144K|FLT1_ENST00000539099.1_Missense_Mutation_p.E144K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	144			E -> K (in dbSNP:rs55974987).		cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGTATAATTTCGGGGATTTCA	0.383000													9	43					0	0	1	0	0
MFAP5	8076	broad.mit.edu	37	12	8800731	8800731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8800731G>A	ENST00000359478.2	-	10	665	c.478C>T	c.(478-480)Cct>Tct	p.P160S	MFAP5_ENST00000433590.2_Missense_Mutation_p.P135S|MFAP5_ENST00000540087.1_Missense_Mutation_p.P150S|MFAP5_ENST00000535336.1_Missense_Mutation_p.P96S|MFAP5_ENST00000543369.1_Missense_Mutation_p.P138S|MFAP5_ENST00000396549.2_Missense_Mutation_p.P150S	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	160						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					TCACAGGGAGGAAGTCGGAAG	0.478000													14	56					0	0	1	0	0
NIPAL4	348938	broad.mit.edu	37	5	156899784	156899784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156899784C>T	ENST00000311946.7	+	6	1333	c.1217C>T	c.(1216-1218)gCt>gTt	p.A406V	NIPAL4_ENST00000435489.2_Missense_Mutation_p.A387V|ADAM19_ENST00000430702.2_Intron	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	406						integral to membrane	receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						ATGCTGCATGCTTTCAAAGAC	0.547000													13	40					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233986949	233986949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233986949G>A	ENST00000359570.5	+	3	331	c.331G>A	c.(331-333)Gac>Aac	p.D111N	INPP5D_ENST00000538935.1_Missense_Mutation_p.D111N|INPP5D_ENST00000474278.1_3'UTR			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	111					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CACAGGCGACGACCCTGAGGA	0.567000													13	29					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172585245	172585245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:172585245C>T	ENST00000534253.2	+	14	1444	c.1276C>T	c.(1276-1278)Cat>Tat	p.H426Y	DYNC1I2_ENST00000397119.3_Missense_Mutation_p.H426Y|DYNC1I2_ENST00000409317.1_Missense_Mutation_p.H420Y|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.H426Y|DYNC1I2_ENST00000409197.1_Missense_Mutation_p.H400Y|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.H400Y|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.H420Y|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.H418Y|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.H400Y|DYNC1I2_ENST00000410079.3_Missense_Mutation_p.H418Y|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.H426Y			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	426					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			GGAGTTGGTTCATAAACAGTC	0.363000													6	16					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216496929	216496929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216496929G>A	ENST00000366943.2	-	8	1823	c.1437C>T	c.(1435-1437)ttC>ttT	p.F479F	USH2A_ENST00000366942.3_Silent_p.F479F|USH2A_ENST00000307340.3_Silent_p.F479F			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	479	Laminin N-terminal.		F -> S.		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.F479F(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGCTTTTACGAACTCTTGAA	0.408000										HNSCC(13;0.011)			16	172					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100523597	100523597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:100523597C>T	ENST00000358544.2	+	29	4676	c.4565C>T	c.(4564-4566)aCc>aTc	p.T1522I	VPS13B_ENST00000357162.2_Missense_Mutation_p.T1497I|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1522					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTACCAAAGACCCAAAAAGAG	0.358000													15	48					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72234479	72234479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:72234479G>A	ENST00000340726.3	-	5	866	c.227C>T	c.(226-228)cCa>cTa	p.P76L	EYA1_ENST00000388742.4_Missense_Mutation_p.P76L|EYA1_ENST00000388741.2_Missense_Mutation_p.P43L|EYA1_ENST00000303824.7_Missense_Mutation_p.P76L|EYA1_ENST00000419131.1_Missense_Mutation_p.P76L|EYA1_ENST00000388743.2_Missense_Mutation_p.P76L|EYA1_ENST00000388740.3_Missense_Mutation_p.P43L	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	76					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AGTTGGTCGTGGGCTGAAACT	0.343000													18	63					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53740812	53740812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53740812G>A	ENST00000333952.4	-	5	1333	c.1168C>T	c.(1168-1170)Ctt>Ttt	p.L390F	ZNF677_ENST00000598513.1_Missense_Mutation_p.L390F			Q86XU0	ZN677_HUMAN	zinc finger protein 677	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		TGTTGGGTAAGGCTTGAACGT	0.413000													11	90					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43821264	43821264	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43821264C>T	ENST00000382031.1	+	5	8338	c.8307C>T	c.(8305-8307)ctC>ctT	p.L2769L	MAP1A_ENST00000399453.1_Silent_p.L2531L|MAP1A_ENST00000300231.5_Silent_p.L2531L			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2531						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGGCAGCCCTCGACTCAGATG	0.587000													62	124					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44261954	44261954	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44261954G>A	ENST00000315087.7	-	6	1303	c.643C>T	c.(643-645)Ccc>Tcc	p.P215S	ST8SIA5_ENST00000538168.1_Missense_Mutation_p.P251S|ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000536490.1_Missense_Mutation_p.P184S	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	215					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						ATGATGCTGGGGTTCACAGTG	0.542000													11	29					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56345295	56345295	+	Silent	SNP	C	C	T	rs149585110	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56345295C>T	ENST00000262290.4	+	13	2395	c.2079C>T	c.(2077-2079)ttC>ttT	p.F693F	LPO_ENST00000421678.2_Silent_p.F610F|LPO_ENST00000543544.1_Silent_p.F634F|LPO_ENST00000582328.1_Silent_p.F610F	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	693					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						CCTATGACTTCGTGGATTGCT	0.567000													44	85					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15904925	15904925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15904925C>T	ENST00000308940.8	+	1	165	c.67C>T	c.(67-69)Ctc>Ttc	p.L23F		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CTTCCCCCACCTCCAGCTGAT	0.587000													60	178					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121973125	121973125	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121973125G>A	ENST00000498619.1	+	2	527	c.89G>A	c.(88-90)gGg>gAg	p.G30E	CASR_ENST00000296154.5_Missense_Mutation_p.G30E|CASR_ENST00000490131.1_Missense_Mutation_p.G30E	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	30					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CAAAAGAAGGGGGACATTATC	0.517000													44	135					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3293298	3293298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3293298G>A	ENST00000219596.1	-	10	2228	c.2189C>T	c.(2188-2190)tCc>tTc	p.S730F	MEFV_ENST00000541159.1_3'UTR|MEFV_ENST00000536379.1_Missense_Mutation_p.S519F|MEFV_ENST00000339854.4_Missense_Mutation_p.S550F	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	730	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	ATTGTAAAAGGAGATGCTTCC	0.542000													24	106					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121693987	121693987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121693987C>T	ENST00000393386.2	+	26	6687	c.6276C>T	c.(6274-6276)ttC>ttT	p.F2092F	PTPRZ1_ENST00000449182.1_Silent_p.F1225F	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2092	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GCAATGAATTCATCATTACCC	0.413000													63	154					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142488856	142488856	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142488856C>T	ENST00000430863.1	-	0	1185					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CAGCGCAGGTCCTCCGAGTTC	0.662000													7	6					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15706608	15706608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15706608G>A	ENST00000396368.3	-	17	3486	c.3280C>T	c.(3280-3282)Cct>Tct	p.P1094S	KIAA0430_ENST00000344181.3_Missense_Mutation_p.P696S|KIAA0430_ENST00000540441.2_Missense_Mutation_p.P929S|KIAA0430_ENST00000551742.1_Missense_Mutation_p.P1094S|KIAA0430_ENST00000602337.1_Missense_Mutation_p.P1091S|KIAA0430_ENST00000548025.1_Missense_Mutation_p.P1091S	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1093						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TTACCTACAGGACTCTTCGAA	0.463000													50	156					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101748762	101748762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101748762C>T	ENST00000506729.1	-	9	1729	c.1558G>A	c.(1558-1560)Gat>Aat	p.D520N	SLCO6A1_ENST00000379807.3_Missense_Mutation_p.D520N|SLCO6A1_ENST00000379810.1_Missense_Mutation_p.D267N|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.D458N|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.D267N			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	520	Kazal-like.					integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TCAATATCATCTCTTCCACAT	0.313000													17	36					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327514	57327514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57327514C>T	ENST00000326441.9	-	10	2659	c.2296G>A	c.(2296-2298)Gaa>Aaa	p.E766K	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.E642K|PEG3_ENST00000593695.1_Missense_Mutation_p.E640K|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.E766K	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	766					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TAGACATTTTCCTTAGTGGGA	0.428000													57	218					0	0	1	0	0
COLEC10	10584	broad.mit.edu	37	8	120103399	120103399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:120103399G>A	ENST00000332843.2	+	3	273	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	COLEC10_ENST00000521788.1_3'UTR	NM_006438.3	NP_006429.2	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 (C-type lectin)	78	Collagen-like.					collagen|cytoplasm	mannose binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			AATTAAAGGAGAACTGGGTGA	0.383000													9	88					0	0	1	0	0
TPP1	1200	broad.mit.edu	37	11	6635912	6635912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6635912G>A	ENST00000533371.1	-	12	1626	c.828C>T	c.(826-828)acC>acT	p.T276T	TPP1_ENST00000299427.6_Silent_p.T519T			O14773	TPP1_HUMAN	tripeptidyl peptidase I	519					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		GGCAGCCACGGGTTACCTAGG	0.532000													27	93					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176308482	176308482	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176308482G>A	ENST00000292432.5	-	18	2539	c.2448C>T	c.(2446-2448)ccC>ccT	p.P816P		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	816	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGAGGTCAGGGGTAGCCCCA	0.652000													10	31					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65245923	65245923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65245923G>A	ENST00000389722.3	-	21	4568	c.4515C>T	c.(4513-4515)gaC>gaT	p.D1505D	SPTB_ENST00000556626.1_Silent_p.D1505D|SPTB_ENST00000542895.1_Silent_p.D1505D|SPTB_ENST00000389721.5_Silent_p.D1505D|SPTB_ENST00000389720.3_Silent_p.D1505D	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1505					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TAGTGCCATAGTCGGCTGACT	0.582000													11	32					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53694250	53694250	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53694250C>T	ENST00000288139.3	+	5	832	c.714C>T	c.(712-714)gcC>gcT	p.A238A	CACNA1D_ENST00000422281.2_Silent_p.A238A|CACNA1D_ENST00000350061.5_Silent_p.A238A	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	238					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ATGTCAAAGCCCTCCGTGCCT	0.453000													25	75					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440076	124440076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124440076G>A	ENST00000284287.3	+	1	184	c.112G>A	c.(112-114)Gca>Aca	p.A38T		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		AACGAAGAGAGCAGACCTCCA	0.527000													26	84					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96123893	96123893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:96123893C>T	ENST00000453304.1	-	12	2473	c.2125G>A	c.(2125-2127)Gat>Aat	p.D709N		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	709	Interaction with DCC (By similarity).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTCAGGGCATCCTGGGTGTCA	0.597000													10	12					0	0	1	0	0
MFAP5	8076	broad.mit.edu	37	12	8802109	8802109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8802109C>T	ENST00000359478.2	-	9	584	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	MFAP5_ENST00000433590.2_Missense_Mutation_p.E108K|MFAP5_ENST00000540087.1_Missense_Mutation_p.E123K|MFAP5_ENST00000535336.1_Intron|MFAP5_ENST00000543369.1_Missense_Mutation_p.E111K|MFAP5_ENST00000396549.2_Missense_Mutation_p.E123K	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	133						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					TTCATAGCTTCGTGTTCCTTA	0.433000													19	42					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40720956	40720956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40720956C>T	ENST00000253055.3	+	10	2910	c.2622C>T	c.(2620-2622)ttC>ttT	p.F874F		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	874					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						CCCCTGAGTTCCCAGGCCGCC	0.711000													9	30					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47274758	47274758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47274758G>A	ENST00000396220.1	-	17	1912	c.1890C>T	c.(1888-1890)ccC>ccT	p.P630P	PREX1_ENST00000371941.3_Silent_p.P630P			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	630	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCTCCTCCTGGGGCAGGATCT	0.672000											OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	268					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	44005977	44005977	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44005977C>T	ENST00000292140.5	-	4	803	c.443G>A	c.(442-444)cGa>cAa	p.R148Q	PHLDB3_ENST00000599242.1_Missense_Mutation_p.R148Q	NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	148										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				AGCGGCCACTCGCTCCCCAGC	0.706000													4	8					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793010	65793010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65793010C>T	ENST00000312106.5	-	1	978	c.841G>A	c.(841-843)Gac>Aac	p.D281N		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	281	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						tggggatggtcgccatggtgg	0.577000													3	11					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32200883	32200883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32200883C>T	ENST00000400246.1	+	17	1341	c.1199C>T	c.(1198-1200)cCt>cTt	p.P400L	DEPDC5_ENST00000536766.1_Missense_Mutation_p.P372L|DEPDC5_ENST00000382111.2_Missense_Mutation_p.P400L|DEPDC5_ENST00000400248.1_Missense_Mutation_p.P400L|DEPDC5_ENST00000400249.2_Missense_Mutation_p.P400L|DEPDC5_ENST00000382105.2_Missense_Mutation_p.P400L|DEPDC5_ENST00000400242.3_Missense_Mutation_p.P400L|DEPDC5_ENST00000535622.1_Missense_Mutation_p.P400L|DEPDC5_ENST00000266091.3_Missense_Mutation_p.P400L|DEPDC5_ENST00000382112.3_Missense_Mutation_p.P400L			O75140	DEPD5_HUMAN	DEP domain containing 5	400					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TATAATATCCCTCACTGGATA	0.433000													21	230					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19176015	19176015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19176015G>A	ENST00000375371.3	-	4	1308	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	429					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCAGGAGAGTGAAGTTGACCT	0.562000													10	50					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131415460	131415460	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:131415460C>T	ENST00000512055.1	-	9	2559	c.432_splice	c.e9-1	p.V145_splice	CPNE4_ENST00000512332.1_Splice_Site_p.V163_splice|CPNE4_ENST00000502818.1_Splice_Site_p.V163_splice|CPNE4_ENST00000429747.1_Splice_Site_p.V145_splice|CPNE4_ENST00000511604.1_Splice_Site_p.V145_splice			Q96A23	CPNE4_HUMAN	copine IV	145	C2 2.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						TCAGCAATCACCTAAAGGAAA	0.403000													25	78					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606558	84606558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84606558G>A	ENST00000344803.2	+	4	1220	c.1173G>A	c.(1171-1173)ggG>ggA	p.G391G		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CCTTTTTAGGGGGGCACTCTG	0.473000													16	49					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90770548	90770548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90770548G>A	ENST00000354366.3	-	5	968	c.736C>T	c.(736-738)Ccc>Tcc	p.P246S	NRDE2_ENST00000357904.3_Missense_Mutation_p.P15S	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		TCAGATGAGGGAGGTTCAGTT	0.448000													43	120					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241700753	241700753	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241700753A>C	ENST00000498729.2	-	24	2404	c.2158T>G	c.(2158-2160)Ttc>Gtc	p.F720V	KIF1A_ENST00000320389.7_Missense_Mutation_p.F711V	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	711					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CACTTCCGGAAGGCCCAGAGC	0.622000													23	46					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33246090	33246090	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33246090C>T	ENST00000404816.2	+	3	1033	c.680C>T	c.(679-681)tCg>tTg	p.S227L	LTBP1_ENST00000354476.3_Missense_Mutation_p.S227L			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	227					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAGGACACCTCGTCACCAGTC	0.552000													78	215					0	0	1	0	0
ACVR1	90	broad.mit.edu	37	2	158617438	158617438	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158617438G>T	ENST00000263640.3	-	9	1647	c.1218C>A	c.(1216-1218)gcC>gcA	p.A406A	ACVR1_ENST00000410057.2_Silent_p.A406A|ACVR1_ENST00000409283.2_Silent_p.A406A|ACVR1_ENST00000434821.1_Silent_p.A406A	NM_001105.4	NP_001096.1	Q04771	ACVR1_HUMAN	activin A receptor, type I	406	Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	19				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	CAAGTCCAAAGGCCCAAATAT	0.458000													5	75					1.024e-07	1.0271e-07	1	1	0
HOXC10	3226	broad.mit.edu	37	12	54379177	54379177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54379177G>A	ENST00000303460.4	+	1	208	c.134G>A	c.(133-135)aGg>aAg	p.R45K	HOXC-AS3_ENST00000514702.1_RNA	NM_017409.3	NP_059105.2	Q9NYD6	HXC10_HUMAN	homeobox C10	45					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R45K(1)		endometrium(2)|large_intestine(3)|lung(14)|pancreas(1)	20						GGGGTGATGAGGGGCTGCGGG	0.662000													13	58					0	0	1	0	0
ADCYAP1	116	broad.mit.edu	37	18	909582	909582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:909582G>A	ENST00000579794.1	+	4	755	c.477G>A	c.(475-477)ggG>ggA	p.G159G	ADCYAP1_ENST00000450565.3_Silent_p.G159G	NM_001117.3	NP_001108.2	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary)	159					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						CCGTCCTAGGGAAGAGGTATA	0.512000													40	199					0	0	1	0	0
RBPMS2	348093	broad.mit.edu	37	15	65042566	65042566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65042566G>A	ENST00000300069.4	-	3	447	c.180C>T	c.(178-180)tcC>tcT	p.S60S	RBPMS2_ENST00000560606.1_5'UTR	NM_194272.1	NP_919248.1	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	60	RRM.						nucleic acid binding|nucleotide binding			breast(1)|large_intestine(3)|lung(3)|prostate(1)	8						GCTTGATCAGGGACCCTTCAT	0.572000													84	241					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38647586	38647586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38647586G>A	ENST00000413689.1	-	10	1387	c.1194C>T	c.(1192-1194)ttC>ttT	p.F398F	SCN5A_ENST00000423572.2_Silent_p.F398F|SCN5A_ENST00000425664.1_Silent_p.F398F|SCN5A_ENST00000333535.4_Silent_p.F398F|SCN5A_ENST00000451551.2_Silent_p.F398F|SCN5A_ENST00000455624.2_Silent_p.F398F|SCN5A_ENST00000449557.2_Silent_p.F398F|SCN5A_ENST00000450102.2_Silent_p.F398F|SCN5A_ENST00000443581.1_Silent_p.F398F|SCN5A_ENST00000414099.2_Silent_p.F398F	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	398					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGGACCCCAGGAAGATGACAA	0.577000													15	64					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119914839	119914839	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:119914839C>T	ENST00000331113.4	+	1	1118	c.153C>T	c.(151-153)cgC>cgT	p.R51R		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	51					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GTGGCACCCGCTTCCAGACGT	0.572000													17	291					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98449122	98449122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98449122C>T	ENST00000450876.1	-	6	1991	c.676G>A	c.(676-678)Gac>Aac	p.D226N	TMEM130_ENST00000345589.4_Missense_Mutation_p.D208N|TMEM130_ENST00000416379.2_Missense_Mutation_p.D310N|TMEM130_ENST00000546258.1_Missense_Mutation_p.D291N|TMEM130_ENST00000339375.4_Missense_Mutation_p.D310N			Q8N3G9	TM130_HUMAN	transmembrane protein 130	310	PKD.					Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAGCAGTAGTCCCCAGGGTCC	0.592000													24	42					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15815444	15815444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15815444C>T	ENST00000338282.6	-	32	4519	c.4413G>A	c.(4411-4413)agG>agA	p.R1471R	NDE1_ENST00000396354.1_Intron|MYH11_ENST00000576790.1_Silent_p.R1471R|NDE1_ENST00000396355.1_Intron|MYH11_ENST00000396324.3_Silent_p.R1478R|NDE1_ENST00000342673.5_Intron|MYH11_ENST00000452625.2_Silent_p.R1478R|MYH11_ENST00000300036.5_Silent_p.R1471R	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1471					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CAGCTCTGTCCCTCTCATCCG	0.557000			T	CBFB	AML								12	70					0	0	1	0	0
TDG	6996	broad.mit.edu	37	12	104370702	104370702	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104370702C>T	ENST00000392872.3	+	2	264	c.30C>T	c.(28-30)tcC>tcT	p.S10S	TDG_ENST00000544861.1_Intron|TDG_ENST00000266775.9_Silent_p.S6S	NM_003211.4	NP_003202.3	Q13569	TDG_HUMAN	thymine-DNA glycosylase	10					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			large_intestine(2)|lung(14)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(302;0.00114)		TCAGCTATTCCCTTCAGCAAG	0.353000								Base excision repair (BER), DNA glycosylases					15	40					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196183	207196183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207196183C>T	ENST00000359470.5	-	4	1175	c.926G>A	c.(925-927)aGc>aAc	p.S309N	C1orf116_ENST00000461135.2_Missense_Mutation_p.S63N	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	309						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					GCTTCGGCTGCTCTTCAGAAC	0.587000													28	50					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54959101	54959101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54959101G>A	ENST00000273286.5	-	2	311	c.149C>T	c.(148-150)cCt>cTt	p.P50L	CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_5'UTR|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	50	LRRNT.					integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		TCGAGTCTGAGGAGGTAAATG	0.473000													6	37					0	0	1	0	0
PDSS1	23590	broad.mit.edu	37	10	26994270	26994270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26994270C>T	ENST00000376215.5	+	4	336	c.283C>T	c.(283-285)Cct>Tct	p.P95S	PDSS1_ENST00000376203.5_Missense_Mutation_p.P95S	NM_014317.3	NP_055132.2	Q5T2R2	DPS1_HUMAN	prenyl (decaprenyl) diphosphate synthase, subunit 1	95					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity			autonomic_ganglia(1)|endometrium(1)|kidney(7)|large_intestine(6)|lung(5)|prostate(1)	21						ATACACCGATCCTTTCAAACT	0.383000													17	39					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207590	58207590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58207590C>T	ENST00000377918.3	+	1	936	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	304	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGGCCTAATCCGTGTGAAGGG	0.577000													18	44					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113102449	113102449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113102449G>A	ENST00000316851.7	+	9	1142	c.1142G>A	c.(1141-1143)gGa>gAa	p.G381E	NCAM1_ENST00000533760.1_Missense_Mutation_p.G263E|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Missense_Mutation_p.G390E	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	391	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ACTGATGCCGGAGAGTACATC	0.597000													30	76					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55782877	55782877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55782877G>A	ENST00000373965.2	-	20	2716	c.2322C>T	c.(2320-2322)tcC>tcT	p.S774S	PCDH15_ENST00000395445.1_Silent_p.S774S|PCDH15_ENST00000409834.1_Silent_p.S378S|PCDH15_ENST00000437009.1_Silent_p.S696S|PCDH15_ENST00000361849.3_Silent_p.S767S|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395433.1_Silent_p.S745S|PCDH15_ENST00000395432.2_Silent_p.S730S|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373955.1_Silent_p.S767S|PCDH15_ENST00000414778.1_Silent_p.S772S|PCDH15_ENST00000395430.1_Silent_p.S767S|PCDH15_ENST00000320301.6_Silent_p.S767S|PCDH15_ENST00000395438.1_Silent_p.S767S	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	767	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCTCCCATTGGATGTGATAC	0.393000										HNSCC(58;0.16)			6	75					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55710208	55710208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55710208G>A	ENST00000376350.3	-	8	1515	c.1493C>T	c.(1492-1494)cCc>cTc	p.P498L	PTPRH_ENST00000263434.5_Missense_Mutation_p.P320L|PTPRH_ENST00000588559.1_5'UTR	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	498	Fibronectin type-III 6.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TGGGCCCTGGGGAGCTGTCCA	0.592000													7	34					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124403488	124403488	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124403488G>A	ENST00000409039.3	+	64	11169	c.11144G>A	c.(11143-11145)gGc>gAc	p.G3715D		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3715					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TATAACCACGGCTGCACAGGT	0.498000													6	72					0	0	1	0	0
IL1F10	84639	broad.mit.edu	37	2	113832841	113832841	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113832841G>A	ENST00000393197.2	+	4	780	c.359G>A	c.(358-360)tGg>tAg	p.W120*	IL1F10_ENST00000341010.2_Nonsense_Mutation_p.W120*|IL1F10_ENST00000337569.3_Nonsense_Mutation_p.W120*	NM_032556.5	NP_115945.4	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	120						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			endometrium(1)|lung(6)|ovary(1)	8						TGGCCTGGCTGGTTCCTGTGT	0.592000													37	147					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202272434	202272434	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202272434G>A	ENST00000367278.3	+	10	1046	c.957G>A	c.(955-957)caG>caA	p.Q319Q	LGR6_ENST00000439764.2_Silent_p.Q180Q|LGR6_ENST00000308543.3_3'UTR|LGR6_ENST00000255432.7_Silent_p.Q267Q	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	319						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						TGGACATCCAGGAGTTTCCAG	0.502000													6	73					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38822908	38822908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38822908C>T	ENST00000303592.3	-	2	1488	c.1230G>A	c.(1228-1230)gaG>gaA	p.E410E	RP3-434P1.6_ENST00000433230.1_RNA	NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	410					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					TGATGCCCGCCTCCTCCTTGG	0.677000													46	116					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8146261	8146261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8146261C>T	ENST00000600128.1	-	58	7731	c.7317G>A	c.(7315-7317)gaG>gaA	p.E2439E	FBN3_ENST00000601739.1_Silent_p.E2439E|FBN3_ENST00000270509.2_Silent_p.E2439E			Q75N90	FBN3_HUMAN	fibrillin 3	2439	EGF-like 39; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TCCTGCCATCCTCCTCCAGCA	0.582000													11	29					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30934525	30934525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30934525C>T	ENST00000355537.3	+	2	203	c.56C>T	c.(55-57)cCc>cTc	p.P19L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GAAGCTGAGCCCCACCTGAGT	0.622000													52	122					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44673604	44673604	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44673604G>A	ENST00000454036.1	+	12	1539		c.e12-1		SLC12A5_ENST00000243964.3_Splice_Site|SLC12A5_ENST00000539566.1_Intron	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5						potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CATCATTCCAGGTTTGGCGAA	0.562000													70	130					0	0	1	0	0
SCN1B	6324	broad.mit.edu	37	19	35524582	35524582	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35524582C>T	ENST00000262631.5	+	3	524	c.387C>T	c.(385-387)ttC>ttT	p.F129F	SCN1B_ENST00000415950.3_Silent_p.F129F|SCN1B_ENST00000596348.1_3'UTR|SCN1B_ENST00000595652.1_Intron	NM_001037.4	NP_001028.1	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta subunit	129	Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	11	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGCTCTTCTTCGAAAACTACG	0.552000													52	122					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71041035	71041035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:71041035G>A	ENST00000452400.2	-	17	3686	c.3505C>T	c.(3505-3507)Cgt>Tgt	p.R1169C	NCOA2_ENST00000267974.4_Missense_Mutation_p.R257C	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1169					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GGCTGCATACGGAGTGTGGCA	0.552000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								17	34					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174955	63174955	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:63174955G>A	ENST00000322893.7	-	11	2506	c.2238C>T	c.(2236-2238)tcC>tcT	p.S746S	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	746					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTCCGGTGATGGAGGCTCCAT	0.537000													7	86					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26690364	26690364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26690364C>T	ENST00000529632.2	+	3	1138	c.942C>T	c.(940-942)gtC>gtT	p.V314V	SEZ6L_ENST00000360929.3_Silent_p.V314V|SEZ6L_ENST00000402979.1_Silent_p.V87V|SEZ6L_ENST00000404234.3_Silent_p.V314V|SEZ6L_ENST00000343706.4_Silent_p.V314V|SEZ6L_ENST00000403121.1_Silent_p.V87V|SEZ6L_ENST00000248933.6_Silent_p.V314V	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	314	CUB 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						ACGTGACAGTCTACACTGGCT	0.552000													47	70					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103772	52103772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52103772C>T	ENST00000361781.2	-	7	1062	c.103G>A	c.(103-105)Gac>Aac	p.D35N	SGMS1_ENST00000361543.2_Missense_Mutation_p.D35N|SGMS1_ENST00000429490.1_Intron	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	41	SAM.				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						TTGATCAAGTCCTGGCCTGTG	0.512000													29	57					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566491	45566491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:45566491C>T	ENST00000588982.1	-	3	1489	c.988G>A	c.(988-990)Gac>Aac	p.D330N	ZBTB7C_ENST00000586438.1_Missense_Mutation_p.D330N|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.D330N|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.D330N|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.D330N			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	330						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GCACCGTAGTCGTTCTCCGCC	0.637000													33	66					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106729593	106729593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:106729593G>A	ENST00000299045.3	+	7	1123	c.949G>A	c.(949-951)Gaa>Aaa	p.E317K		NM_152772.1	NP_689985.1	Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	317										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						TCAGAAAAAAGAATTACCAGA	0.388000													12	64					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841626	94841626	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94841626G>A	ENST00000357742.4	+	1	132	c.132G>A	c.(130-132)ttG>ttA	p.L44L	MCTP2_ENST00000543482.1_Silent_p.L44L|MCTP2_ENST00000451018.3_Silent_p.L44L|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	44					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GGCATCACTTGGACCGCCGTC	0.572000													24	107					0	0	1	0	0
AGMAT	79814	broad.mit.edu	37	1	15909693	15909693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15909693G>A	ENST00000375826.3	-	2	612	c.470C>T	c.(469-471)aCc>aTc	p.T157I	DNAJC16_ENST00000483270.1_Intron	NM_024758.4	NP_079034.3	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase)	157					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(2)|skin(1)	12		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		ATTACCCAAGGTCAGAGGAAT	0.493000													15	43					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631512	32631512	+	Missense_Mutation	SNP	G	G	A	rs56107531		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32631512G>A	ENST00000242310.4	-	1	4155	c.4066C>T	c.(4066-4068)Cgc>Tgc	p.R1356C		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1356			R -> C (in dbSNP:rs56107531).		male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GATTTTCTGCGAACCTCATGC	0.398000													103	213					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8200927	8200927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8200927G>A	ENST00000600128.1	-	13	1923	c.1509C>T	c.(1507-1509)ggC>ggT	p.G503G	FBN3_ENST00000601739.1_Silent_p.G503G|FBN3_ENST00000270509.2_Silent_p.G503G			Q75N90	FBN3_HUMAN	fibrillin 3	503	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGACACAGCGGCCCAGGTGAC	0.632000													7	25					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168678406	168678406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168678406C>T	ENST00000519560.1	-	2	674	c.255G>A	c.(253-255)aaG>aaA	p.K85K	SLIT3_ENST00000332966.8_Silent_p.K85K|SLIT3_ENST00000521130.1_5'UTR|SLIT3_ENST00000404867.3_Silent_p.K85K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	85					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCGGAGGTTCTTGAGCCCAG	0.443000													28	89					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219299356	219299356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219299356G>A	ENST00000248444.5	+	14	1696	c.1608G>A	c.(1606-1608)cgG>cgA	p.R536R	VIL1_ENST00000392114.2_Silent_p.R225R	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	536	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCCAGCGCGGGCCAATTTCC	0.567000													31	91					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10369690	10369690	+	Missense_Mutation	SNP	G	G	A	rs112133139		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10369690G>A	ENST00000255381.2	-	4	358	c.248C>T	c.(247-249)cCc>cTc	p.P83L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	83	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.P83L(1)		NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTCATATTTGGGAGGGTTCAT	0.438000													56	81					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76868005	76868005	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76868005G>A	ENST00000409709.3	+	7	962	c.690G>A	c.(688-690)gcG>gcA	p.A230A	MYO7A_ENST00000409619.2_Silent_p.A219A|MYO7A_ENST00000409893.1_Silent_p.A230A|MYO7A_ENST00000458637.2_Silent_p.A230A	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	230	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TCGAGGGCGCGAAGATTGAGC	0.582000													25	57					0	0	1	0	0
AADACL3	126767	broad.mit.edu	37	1	12785747	12785747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12785747C>T	ENST00000332530.3	+	3	853	c.627C>T	c.(625-627)ctC>ctT	p.L209L	AADACL3_ENST00000359318.5_Silent_p.L279L	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	279							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCTCAGCTCCCGGAAACCT	0.522000													58	89					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42509145	42509145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42509145G>A	ENST00000381668.5	-	23	2205	c.1974C>T	c.(1972-1974)gcC>gcT	p.A658A	ATP8A1_ENST00000264449.10_Silent_p.A643A	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	658					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	TATCCTCAATGGCTGTTGCTC	0.343000													40	123					0	0	1	0	0
C2CD4A	145741	broad.mit.edu	37	15	62359880	62359880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:62359880C>T	ENST00000355522.5	+	2	209	c.68C>T	c.(67-69)cCg>cTg	p.P23L		NM_207322.2	NP_997205.2	Q8NCU7	C2C4A_HUMAN	C2 calcium-dependent domain containing 4A	23						nucleus											TGGCTTCTCCCGGGTCGGGCC	0.667000													22	25					0	0	1	0	0
SPANXN3	139067	broad.mit.edu	37	X	142596707	142596707	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142596707G>A	ENST00000370503.2	-	2	446	c.363C>T	c.(361-363)tcC>tcT	p.S121S	GS1-256O22.5_ENST00000431432.1_RNA	NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	121										endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCTGTGAGGATCCTTCAG	0.458000													69	43					0	0	1	0	0
WFDC5	149708	broad.mit.edu	37	20	43739057	43739057	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43739057G>A	ENST00000307971.4	-	3	429	c.351C>T	c.(349-351)tgC>tgT	p.C117C	WFDC5_ENST00000372789.4_Silent_p.C117C			Q8TCV5	WFDC5_HUMAN	WAP four-disulfide core domain 5	117	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				CAGGATCCCGGCAATCCCGCC	0.607000													6	19					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129095170	129095170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129095170C>T	ENST00000249344.2	+	8	832	c.792C>T	c.(790-792)ttC>ttT	p.F264F	STRIP2_ENST00000435494.2_Silent_p.F264F	NM_020704.2	NP_065755.1			striatin interacting protein 2																		CTCCTCACTTCCCCATAAAGA	0.517000													13	167					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914613	51914613	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51914613T>G	ENST00000353836.5	-	10	1770	c.1549A>C	c.(1549-1551)Aat>Cat	p.N517H	SIGLEC10_ENST00000339313.5_Missense_Mutation_p.N612H|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.N554H|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.N369H|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.N427H|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.N469H|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.N612H|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.N434H|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.N459H	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	612					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GCTTTCTGATTCCGCTTCTGA	0.502000													23	63					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642599	57642599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57642599C>T	ENST00000254181.4	+	4	3010	c.2556C>T	c.(2554-2556)gcC>gcT	p.A852A	USP29_ENST00000598197.1_Silent_p.A852A	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	852					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGAAGCAGGCCTGGTTCACAT	0.468000													18	52					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83195246	83195246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:83195246C>T	ENST00000398309.2	-	17	2374	c.1904G>A	c.(1903-1905)aGc>aAc	p.S635N	DLG2_ENST00000524982.1_Intron|DLG2_ENST00000543673.1_Missense_Mutation_p.S740N|DLG2_ENST00000418306.2_Intron|DLG2_ENST00000532653.1_Intron|DLG2_ENST00000426717.2_Intron|DLG2_ENST00000280241.8_Missense_Mutation_p.S674N|DLG2_ENST00000376106.3_Intron|DLG2_ENST00000398304.1_Intron|DLG2_ENST00000531015.1_Missense_Mutation_p.S602N|DLG2_ENST00000330014.6_Intron|DLG2_ENST00000537455.1_Intron|DLG2_ENST00000376104.2_Missense_Mutation_p.S740N|DLG2_ENST00000404783.3_Intron	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	635						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				AAAGATGAAGCTCTTTTTACG	0.413000													30	97					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32800019	32800019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32800019C>T	ENST00000380250.3	+	39	5610	c.5114C>T	c.(5113-5115)tCc>tTc	p.S1705F		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AATTTCCATTCCATTGCTTCC	0.483000													47	90					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55340173	55340173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55340173C>T	ENST00000314634.3	+	1	570	c.570C>T	c.(568-570)acC>acT	p.T190T		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				GTTCAGAAACCTATGTGGTTA	0.433000													22	90					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205549800	205549800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205549800C>T	ENST00000367147.4	+	3	534	c.441C>T	c.(439-441)ttC>ttT	p.F147F	MFSD4_ENST00000539267.1_Silent_p.F147F|MFSD4_ENST00000536357.1_Intron	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	147					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TGCTCCATTTCTTCGTGGGCT	0.637000													15	168					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29429863	29429863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29429863G>A	ENST00000377136.1	+	4	782	c.317G>A	c.(316-318)gGg>gAg	p.G106E	OR2H1_ENST00000377133.1_Missense_Mutation_p.G106E|OR2H1_ENST00000442615.1_Missense_Mutation_p.G106E|OR2H1_ENST00000396792.2_Missense_Mutation_p.G106E|OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377132.1_Missense_Mutation_p.G106E			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						CTGTCCCTGGGGACCACTGAG	0.587000													41	103					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109840830	109840830	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109840830C>G	ENST00000357155.1	-	2	244	c.195G>C	c.(193-195)cgG>cgC	p.R65R	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	65	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CCCCAACCTTCCGGATGTAGG	0.522000													24	126					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68882677	68882677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:68882677C>T	ENST00000303786.3	+	3	1571	c.1151C>T	c.(1150-1152)aCc>aTc	p.T384I	PROKR1_ENST00000394342.2_Missense_Mutation_p.T384I			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	384						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.T384N(1)		endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ATGCCTGCCACCGAAGAGGTG	0.483000													14	44					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15874868	15874868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15874868C>T	ENST00000375847.3	+	7	1132	c.968C>T	c.(967-969)gCc>gTc	p.A323V	DNAJC16_ENST00000375838.1_Missense_Mutation_p.A323V|DNAJC16_ENST00000375849.1_Missense_Mutation_p.A323V	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	323					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AATATCTACGCCCCTACCCTC	0.413000													17	57					0	0	1	0	0
TPTEP1	387590	broad.mit.edu	37	22	17119552	17119552	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17119552C>T	ENST00000426585.1	+	0	364																											CTTTATATTCCTTCGGAGTAT	0.348000													24	80					0	0	1	0	0
CAMK1D	57118	broad.mit.edu	37	10	12595318	12595318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:12595318G>A	ENST00000378847.3	+	2	524	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	CAMK1D_ENST00000487696.1_Intron|CAMK1D_ENST00000378845.1_Missense_Mutation_p.E63K	NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	63	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		GAAGGGCAAGGAAAGCAGCAT	0.542000													32	76					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4968027	4968027	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4968027G>A	ENST00000380373.2	-	1	329	c.304C>T	c.(304-306)Cag>Tag	p.Q102*	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGAATTCCTGGGCAAAGCAG	0.448000													59	140					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226080	23226080	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23226080G>A	ENST00000300061.2	+	12	1684	c.1541G>A	c.(1540-1542)aGa>aAa	p.R514K		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	514					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	CTGAACCAGAGATCCATCATG	0.502000													18	37					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43858077	43858077	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43858077G>A	ENST00000378009.4	+	0	167				CD177_ENST00000378012.2_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CCCCGGCAATGGACCCCTAAG	0.612000													33	64					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2164218	2164218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2164218G>A	ENST00000262304.4	-	11	3014	c.2806C>T	c.(2806-2808)Cgc>Tgc	p.R936C	PKD1_ENST00000423118.1_Missense_Mutation_p.R936C	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	936	PKD 4.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GGCGTGGCGCGGAGGCCACAG	0.697000													9	30					0	0	1	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119945434	119945434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:119945434G>A	ENST00000297350.4	-	2	514	c.136C>T	c.(136-138)Cct>Tct	p.P46S		NM_002546.3	NP_002537.3	O00300	TR11B_HUMAN	tumor necrosis factor receptor superfamily, member 11b	46					apoptosis|skeletal system development		cytokine activity|receptor activity			breast(1)|central_nervous_system(3)|endometrium(4)|large_intestine(6)|lung(7)|prostate(3)|skin(1)	25	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			TAGGTACCAGGAGGACATTTG	0.498000													57	235					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94944637	94944637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94944637C>T	ENST00000222381.3	-	4	598	c.367G>A	c.(367-369)Gaa>Aaa	p.E123K	PON1_ENST00000542556.1_Missense_Mutation_p.E123K	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	123					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TTGTTACCTTCATCTGTGAAT	0.303000													10	33					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36897018	36897018	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36897018G>A	ENST00000301807.6	-	12	4310	c.2413C>T	c.(2413-2415)Cag>Tag	p.Q805*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.Q1355*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.Q805*	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1355					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CTGATTTGCTGATACAGACTG	0.473000													36	122					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680148	114680148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114680148G>A	ENST00000393296.1	-	3	1117	c.1040C>T	c.(1039-1041)tCc>tTc	p.S347F	SYT6_ENST00000369547.1_Missense_Mutation_p.S262F			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	347					acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCCAGATGGAGGTTTCCCG	0.522000													33	66					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027464	55027464	+	Missense_Mutation	SNP	C	C	T	rs112730552	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:55027464C>T	ENST00000371336.3	+	5	1433	c.1232C>T	c.(1231-1233)tCc>tTc	p.S411F	CASS4_ENST00000360314.3_Missense_Mutation_p.S411F|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	411	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						AGCATCGTTTCCTCGTGCTCC	0.552000													15	26					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15843396	15843396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:15843396C>T	ENST00000217246.4	+	9	1047	c.652C>T	c.(652-654)Cgg>Tgg	p.R218W	MACROD2_ENST00000310348.4_Missense_Mutation_p.R218W|MACROD2_ENST00000402914.1_5'UTR	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	218	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CTAGGTGGATCGGATCATTTT	0.368000													11	43					0	0	1	0	0
RASGRP3	25780	broad.mit.edu	37	2	33783919	33783919	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33783919G>A	ENST00000403687.3	+	17	2626	c.1886G>A	c.(1885-1887)gGg>gAg	p.G629E	RASGRP3_ENST00000402538.3_Missense_Mutation_p.G629E|RASGRP3_ENST00000407811.1_Missense_Mutation_p.G628E|AC020594.5_ENST00000437680.1_RNA	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	629					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					GGGGACTCGGGGTCCCACACC	0.557000													20	73					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10312885	10312885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10312885G>A	ENST00000403437.2	-	16	1702	c.1608C>T	c.(1606-1608)atC>atT	p.I536I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	536	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CCTCTTCCAGGATGGAGAAGA	0.473000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				29	55					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088839	9088839	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9088839G>A	ENST00000397910.4	-	1	3179	c.2976C>T	c.(2974-2976)ctC>ctT	p.L992L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	992	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTAGCAGAGAGAGAAGTGG	0.473000													76	221					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206610475	206610475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206610475C>T	ENST00000360409.3	+	10	2438	c.1647C>T	c.(1645-1647)ttC>ttT	p.F549F	NRP2_ENST00000357118.4_Silent_p.F549F|NRP2_ENST00000540841.1_Silent_p.F549F|NRP2_ENST00000540178.1_Silent_p.F549F|NRP2_ENST00000357785.5_Silent_p.F549F|NRP2_ENST00000272849.3_Silent_p.F549F|NRP2_ENST00000412873.2_Silent_p.F549F	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	549	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity	p.F549F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						TGCAGCTGTTCGAAGGGAACA	0.612000													12	28					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149508081	149508081	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149508081C>T	ENST00000378016.2	+	0	9475							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CACTGTGGTTCGTCCATGTGA	0.602000													6	49					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210977336	210977336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210977336G>A	ENST00000367007.4	-	8	1723	c.1554C>T	c.(1552-1554)tcC>tcT	p.S518S	KCNH1_ENST00000271751.4_Silent_p.S545S	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	545					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTCTGGACATGGACCAAGTGG	0.483000													39	113					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48416519	48416519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48416519G>A	ENST00000249598.1	-	1	334	c.175C>T	c.(175-177)Ctg>Ttg	p.L59L		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	59					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						ACGTTCTCCAGAAACATCTTC	0.607000													6	55					0	0	1	0	0
IFITM1	8519	broad.mit.edu	37	11	314350	314350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:314350C>T	ENST00000408968.3	+	1	498	c.180C>T	c.(178-180)tcC>tcT	p.S60S	IFITM1_ENST00000328221.5_Silent_p.S60S|IFITM1_ENST00000528780.1_Silent_p.S60S	NM_003641.3	NP_003632.3	P13164	IFM1_HUMAN	interferon induced transmembrane protein 1	60					negative regulation of cell proliferation|regulation of immune response|response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding|receptor signaling protein activity			large_intestine(1)|lung(3)	4		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		TCGCCTACTCCGTGAAGGTGC	0.622000													13	167					0	0	1	0	0
HMGB4	127540	broad.mit.edu	37	1	34329958	34329958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34329958G>A	ENST00000522796.1	+	4	2071	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K	CSMD2_ENST00000373381.4_Intron|HMGB4_ENST00000425537.1_3'UTR|HMGB4_ENST00000519684.1_Missense_Mutation_p.E56K			B2R4X7	B2R4X7_HUMAN	high mobility group box 4	56						nucleus	DNA binding			NS(1)|breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CTCAAAGCATGAAAAGGCCAA	0.423000													48	109					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870918	13870918	+	Silent	SNP	C	C	T	rs141079124		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13870918C>T	ENST00000265104.4	-	24	3896	c.3792G>A	c.(3790-3792)agG>agA	p.R1264R	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1264	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTTGCTCCTCCCTTATTTCTT	0.338000									Kartagener syndrome				15	59					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	313789	313789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:313789C>T	ENST00000428720.1	-	4	1033	c.290G>A	c.(289-291)gGc>gAc	p.G97D	RP11-283I3.2_ENST00000539568.1_RNA|SLC6A12_ENST00000359674.4_Missense_Mutation_p.G97D|SLC6A12_ENST00000536824.1_Missense_Mutation_p.G97D|SLC6A12_ENST00000424061.2_Missense_Mutation_p.G97D|SLC6A12_ENST00000397296.2_Missense_Mutation_p.G97D	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	97					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GGTGTATTGGCCCAACGCCAC	0.582000													17	48					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16980627	16980627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16980627C>T	ENST00000379803.1	+	14	2273	c.2259C>T	c.(2257-2259)gcC>gcT	p.A753A	SIN3B_ENST00000248054.5_Silent_p.A721A|SIN3B_ENST00000595541.1_Silent_p.A311A	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	753					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						ATGCCCCGGCCACTGAGCAGC	0.662000													19	41					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128477589	128477589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128477589C>T	ENST00000325888.8	+	4	1098	c.837C>T	c.(835-837)atC>atT	p.I279I	FLNC_ENST00000346177.6_Silent_p.I279I	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	279					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						AGAAAGCCATCGCCTATGGGC	0.597000													23	75					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66914311	66914311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66914311C>T	ENST00000269080.2	-	14	1941	c.1804G>A	c.(1804-1806)Gaa>Aaa	p.E602K	ABCA8_ENST00000586539.1_Missense_Mutation_p.E642K|ABCA8_ENST00000430352.2_Missense_Mutation_p.E642K	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	602	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GCAGTTGGTTCATCCAACAGG	0.403000													9	60					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57254689	57254689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57254689G>A	ENST00000343433.6	-	3	956	c.876C>T	c.(874-876)gcC>gcT	p.A292A	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	292										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						GCCTCTGAAAGGCCTGGAGGT	0.587000													7	115					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149323976	149323976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149323976G>A	ENST00000255266.5	-	1	380	c.261C>T	c.(259-261)ttC>ttT	p.F87F		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	87	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CCTGCAGGAGGAAGCACAGCT	0.517000													6	63					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459983	107459983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107459983G>A	ENST00000409382.3	-	2	1061	c.451C>T	c.(451-453)Cct>Tct	p.P151S	ST6GAL2_ENST00000409087.3_Missense_Mutation_p.P151S|ST6GAL2_ENST00000361686.4_Missense_Mutation_p.P151S	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	151					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CCGGGGGAAGGGAATCCCAAT	0.607000													65	174					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432372	30432372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30432372C>T	ENST00000375978.3	-	1	1048	c.974G>A	c.(973-975)gGa>gAa	p.G325E		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	325					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.G325E(1)		kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						GAAGAACATTCCTGGCGTCCG	0.617000													28	79					0	0	1	0	0
TMEM183A	92703	broad.mit.edu	37	1	202991991	202991991	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202991991C>T	ENST00000367242.3	+	8	1034	c.954C>T	c.(952-954)atC>atT	p.I318I		NM_001079809.1|NM_138391.4	NP_001073277.1|NP_612400.3			transmembrane protein 183A											endometrium(1)|large_intestine(2)|lung(1)|skin(3)	7			BRCA - Breast invasive adenocarcinoma(75;0.18)			AGTTTACTATCAATGTGAGCA	0.448000													59	158					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227922301	227922301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227922301G>A	ENST00000396625.3	-	29	2606	c.2399C>T	c.(2398-2400)cCt>cTt	p.P800L	COL4A4_ENST00000329662.7_Missense_Mutation_p.P800L	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	800	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TAGGAATCCAGGAATGCCAGC	0.478000													11	31					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36118737	36118737	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36118737C>A	ENST00000303965.4	-	25	4473	c.3984G>T	c.(3982-3984)ttG>ttT	p.L1328F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1328	Ras-associating.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTTCAATTAACAAATCTCCAG	0.363000													7	34					0.00198382	0.00198538	1	1	0
FAM120C	54954	broad.mit.edu	37	X	54184166	54184166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54184166G>A	ENST00000375180.2	-	3	1041	c.985C>T	c.(985-987)Cac>Tac	p.H329Y	FAM120C_ENST00000328235.4_Missense_Mutation_p.H329Y	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	329										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						AGGCTCCAGTGAAAAGCAGCC	0.423000													10	9					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17411114	17411114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17411114G>A	ENST00000375486.4	-	8	981	c.918C>T	c.(916-918)ccC>ccT	p.P306P	PADI2_ENST00000375481.1_Silent_p.P306P|PADI2_ENST00000444885.2_Intron	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	306					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ACACCGACACGGGAGGCAGGA	0.587000													2	2					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626236	140626236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140626236G>A	ENST00000231173.3	+	1	1090	c.1090G>A	c.(1090-1092)Gaa>Aaa	p.E364K		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		364	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCAGAGACAGAAGTGGCCCT	0.423000													25	99					0	0	1	0	0
GBP3	2635	broad.mit.edu	37	1	89477649	89477649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89477649C>T	ENST00000370481.4	-	7	1150	c.930G>A	c.(928-930)atG>atA	p.M310I		NM_018284.2	NP_060754.2	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	310						integral to membrane	GTP binding|GTPase activity			breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		CTGCGTTCTCCATGCAGGGCA	0.498000													27	49					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84510501	84510501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84510501G>A	ENST00000360700.4	+	4	1202	c.316G>A	c.(316-318)Gaa>Aaa	p.E106K	ZNF711_ENST00000373165.3_Missense_Mutation_p.E106K|ZNF711_ENST00000276123.3_Missense_Mutation_p.E106K|ZNF711_ENST00000395402.1_Missense_Mutation_p.E84K			Q9Y462	ZN711_HUMAN	zinc finger protein 711	106					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GGATTTAGAGGAAGATGATGG	0.438000													63	48					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74004305	74004305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74004305C>T	ENST00000301607.3	-	22	5234	c.4981G>A	c.(4981-4983)Gac>Aac	p.D1661N	EVPL_ENST00000586740.1_Missense_Mutation_p.D1683N	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1661	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCGTGGAGGTCCCGGAGCGTC	0.672000													25	63					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146350703	146350703	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:146350703C>T	ENST00000392299.2	+	2	520	c.50C>T	c.(49-51)tCc>tTc	p.S17F	GRM1_ENST00000355289.4_Missense_Mutation_p.S17F|GRM1_ENST00000492807.2_Missense_Mutation_p.S17F|GRM1_ENST00000282753.1_Missense_Mutation_p.S17F|GRM1_ENST00000507907.1_Missense_Mutation_p.S17F|GRM1_ENST00000361719.2_Missense_Mutation_p.S17F			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	17					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTGGAGGTGTCCCTTCTCCCC	0.602000													99	114					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41153949	41153949	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41153949C>T	ENST00000263413.3	-	15	2517	c.2253G>A	c.(2251-2253)tgG>tgA	p.W751*	C6_ENST00000337836.5_Nonsense_Mutation_p.W751*	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	751	C5b-binding domain.|Sushi 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGGGTGGTGTCCAGGAATTCC	0.473000													9	64					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148963692	148963692	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148963692C>T	ENST00000434415.1	+	2	454	c.291C>T	c.(289-291)gcC>gcT	p.A97A		NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	97					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GCAAGTGGGCCGTGCTGGGGA	0.632000													29	99					0	0	1	0	0
NKD1	85407	broad.mit.edu	37	16	50667106	50667106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50667106C>T	ENST00000268459.3	+	10	1051	c.827C>T	c.(826-828)tCc>tTc	p.S276F		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	276					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		TTCCTAGGCTCCCCTTCCGTG	0.582000													25	55					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114290179	114290179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114290179G>A	ENST00000374374.3	+	2	679	c.504G>A	c.(502-504)gaG>gaA	p.E168E	ZNF483_ENST00000355824.3_Intron|ZNF483_ENST00000358151.4_Intron|ZNF483_ENST00000309235.5_Intron			Q8TF39	ZN483_HUMAN	zinc finger protein 483	104					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						CTGCTAAAGaggagtctgagg	0.408000													7	8					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606482	55606482	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55606482G>A	ENST00000378396.1	+	1	255	c.255G>A	c.(253-255)gtG>gtA	p.V85V		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TGATGCTGGTGAACCTGGTTG	0.393000													107	240					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15326031	15326031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15326031G>A	ENST00000378116.4	-	2	177	c.171C>T	c.(169-171)ttC>ttT	p.F57F		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	57						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CCTGGTTGGTGAAGATCTCGA	0.552000													22	48					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013381	107013381	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107013381C>T	ENST00000390625.2	-	0	96																											GAAAACCCAGCTAAGCCCAAA	0.493000													36	200					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25718682	25718682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:25718682G>A	ENST00000520164.1	-	13	1762	c.1225C>T	c.(1225-1227)Ccc>Tcc	p.P409S	EBF2_ENST00000408929.3_Missense_Mutation_p.P261S|EBF2_ENST00000535548.1_Missense_Mutation_p.P140S	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	409					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		AGCTGGCTGGGATTCCTGGGG	0.527000													39	90					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61557841	61557841	+	Missense_Mutation	SNP	G	G	A	rs149412997	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61557841G>A	ENST00000290866.4	+	5	823	c.799G>A	c.(799-801)Gga>Aga	p.G267R	ACE_ENST00000584529.1_3'UTR|ACE_ENST00000428043.1_Missense_Mutation_p.G267R|ACE_ENST00000538928.1_Missense_Mutation_p.G267R	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	267	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TCGCCGATACGGAGACAGATA	0.607000													34	87					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57672040	57672040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57672040C>T	ENST00000554048.2	-	2	150	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	51						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		GTATTGATTTCTAAAGCAAGT	0.393000													28	100					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117552834	117552834	+	Silent	SNP	G	G	A	rs142354033		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117552834G>A	ENST00000374045.4	-	4	767	c.654C>T	c.(652-654)ttC>ttT	p.F218F	TNFSF15_ENST00000374044.1_Silent_p.F141F	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	218					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						CTTGCAAGGAGAACATGGCTC	0.488000													16	82					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39755530	39755530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39755530G>A	ENST00000442448.1	-	11	1455	c.1184C>T	c.(1183-1185)cCc>cTc	p.P395L	ERG_ENST00000453032.2_Missense_Mutation_p.P320L|ERG_ENST00000398907.1_Missense_Mutation_p.P389L|ERG_ENST00000398911.1_Missense_Mutation_p.P395L|ERG_ENST00000398919.2_Missense_Mutation_p.P419L|ERG_ENST00000398905.1_Missense_Mutation_p.P388L|ERG_ENST00000398910.1_Missense_Mutation_p.P396L|ERG_ENST00000417133.2_Missense_Mutation_p.P419L|ERG_ENST00000398897.1_Missense_Mutation_p.P296L|ERG_ENST00000288319.7_Missense_Mutation_p.P412L	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	419					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				GAGGTCTGAGGGGTACTTGTA	0.607000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								24	80					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48602929	48602929	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48602929C>T	ENST00000328333.8	-	115	8548	c.8440_splice	c.e115-1	p.R2814_splice	COL7A1_ENST00000454817.1_Splice_Site_p.R2782_splice	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2814	Nonhelical region (NC2).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGGAGGGGTCCTGGAGCCAA	0.642000													8	16					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52547965	52547965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52547965C>T	ENST00000321725.6	+	32	3491	c.3415C>T	c.(3415-3417)Cct>Tct	p.P1139S		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1139	FAS1 4.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGACTTGGTGCCTGCCTTCAG	0.642000													53	121					0	0	1	0	0
VIPAS39	63894	broad.mit.edu	37	14	77910637	77910637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77910637G>A	ENST00000553888.1	-	8	1062	c.552C>T	c.(550-552)ctC>ctT	p.L184L	VIPAS39_ENST00000557658.1_Silent_p.L184L|VIPAS39_ENST00000327028.4_Silent_p.L171L|VIPAS39_ENST00000448935.2_Silent_p.L135L|VIPAS39_ENST00000556412.1_Silent_p.L210L|VIPAS39_ENST00000343765.2_Silent_p.L184L	NM_001193314.1|NM_001193317.1|NM_022067.3	NP_001180243.1|NP_001180246.1|NP_071350.2			VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog																		CCTCTTCTAGGAGTTGTAGTT	0.383000													21	56					0	0	1	0	0
TET2	54790	broad.mit.edu	37	4	106155412	106155412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:106155412G>A	ENST00000513237.1	+	3	1173	c.376G>A	c.(376-378)Ggg>Agg	p.G126R	TET2_ENST00000545826.1_Missense_Mutation_p.G105R|TET2_ENST00000394764.1_Missense_Mutation_p.G105R|TET2_ENST00000413648.2_Missense_Mutation_p.G105R|TET2_ENST00000380013.4_Missense_Mutation_p.G105R|TET2_ENST00000305737.2_Missense_Mutation_p.G105R|TET2_ENST00000540549.1_Missense_Mutation_p.G105R			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	105					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TTCTCTCTCTGGGCTCCTTCA	0.423000			"""Mis N, F"""		MDS								26	53					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220355492	220355492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220355492G>A	ENST00000312358.7	+	38	9331	c.9199G>A	c.(9199-9201)Gtg>Atg	p.V3067M	SPEG_ENST00000485813.1_3'UTR|AC053503.11_ENST00000429882.1_RNA	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	3067	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CACTTACATGGTGCAGCTGCT	0.602000													26	79					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82785261	82785261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82785261C>T	ENST00000423517.2	-	2	1033	c.696G>A	c.(694-696)caG>caA	p.Q232Q	PCLO_ENST00000333891.8_Silent_p.Q232Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	232	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GAGTGCCATCCTGCTGAAGCG	0.468000													17	31					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54776454	54776454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54776454C>T	ENST00000218436.6	-	13	3845	c.3816G>A	c.(3814-3816)gtG>gtA	p.V1272V		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1272					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TGCCTAGAATCACAGGCACAT	0.602000													17	5					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47363609	47363609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47363609C>T	ENST00000545968.1	-	18	1777	c.1723G>A	c.(1723-1725)Ggt>Agt	p.G575S	MYBPC3_ENST00000256993.4_Missense_Mutation_p.G574S|MYBPC3_ENST00000399249.2_Missense_Mutation_p.G575S	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	574	Ig-like C2-type 4.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		AGCCACACACCCCGAACATTC	0.577000													8	15					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46143848	46143848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46143848G>A	ENST00000374366.3	-	6	706	c.241C>T	c.(241-243)Cct>Tct	p.P81S	ZFAND4_ENST00000374370.1_5'UTR|ZFAND4_ENST00000374371.2_Missense_Mutation_p.P155S|ZFAND4_ENST00000344646.5_Missense_Mutation_p.P155S			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	155	Ubiquitin-like.						zinc ion binding										TCTACTGCAGGAAAGAAATTC	0.413000													20	162					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55195914	55195914	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:55195914G>A	ENST00000396834.1	+	10	1462	c.966G>A	c.(964-966)ggG>ggA	p.G322G	IL31RA_ENST00000396836.2_Silent_p.G341G|IL31RA_ENST00000490985.1_Silent_p.G199G|IL31RA_ENST00000354961.4_Silent_p.G322G|IL31RA_ENST00000359040.5_Silent_p.G341G|IL31RA_ENST00000297015.3_Silent_p.G199G|IL31RA_ENST00000447346.2_Silent_p.G341G	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	309	Fibronectin type-III 4.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ATTCTCTTGGGAAGTCTCCAG	0.453000													20	194					0	0	1	0	0
THBD	7056	broad.mit.edu	37	20	23029230	23029230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23029230G>A	ENST00000377103.2	-	1	1148	c.912C>T	c.(910-912)ggC>ggT	p.G304G		NM_000361.2	NP_000352.1	P07204	TRBM_HUMAN	thrombomodulin	304	EGF-like 2.				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity			endometrium(2)|large_intestine(3)|ovary(1)|skin(1)	7	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	ACGAGTAGGAGCCCGGCTGGT	0.687000													8	15					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39265290	39265290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39265290C>T	ENST00000280481.7	+	1	4025	c.3809C>T	c.(3808-3810)tCc>tTc	p.S1270F		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1270					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CATGATGACTCCGAGACCCAG	0.428000													110	250					0	0	1	0	0
RTP3	83597	broad.mit.edu	37	3	46541948	46541948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46541948G>A	ENST00000296142.3	+	2	830	c.258G>A	c.(256-258)atG>atA	p.M86I		NM_031440.1	NP_113628.1	Q9BQQ7	RTP3_HUMAN	receptor (chemosensory) transporter protein 3	86					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			endometrium(1)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		AGGTGAAGATGAGGGTGTTTA	0.522000													13	187					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130287	45130287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45130287C>T	ENST00000457685.2	-	6	2900	c.1577G>A	c.(1576-1578)aGa>aAa	p.R526K	ZNF334_ENST00000593880.1_Missense_Mutation_p.R587K|ZNF334_ENST00000347606.4_Missense_Mutation_p.R564K			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TGTGTGTGTTCTCTGATGGTG	0.463000													59	156					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439392	150439392	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150439392C>T	ENST00000358647.3	+	3	532	c.165C>T	c.(163-165)tcC>tcT	p.S55S	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTTTGAGTCCAAGCTGAGGG	0.562000													27	62					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31743882	31743882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:31743882G>A	ENST00000396556.2	-	7	1336	c.1214C>T	c.(1213-1215)tCa>tTa	p.S405L	OSBPL10_ENST00000438237.2_Missense_Mutation_p.S341L	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	405					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		TTTGAGTTGTGAAATGAGATG	0.428000													13	58					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15487565	15487565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:15487565G>A	ENST00000341776.2	+	6	942	c.698G>A	c.(697-699)cGg>cAg	p.R233Q	JARID2_ENST00000541660.1_Missense_Mutation_p.R195Q|JARID2_ENST00000397311.3_Missense_Mutation_p.R61Q	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	233					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGGTCAACACGGGAGAAGGAA	0.493000													15	40					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327124	52327124	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52327124C>T	ENST00000339223.4	+	2	302	c.123C>T	c.(121-123)gtC>gtT	p.V41V	FPR3_ENST00000595991.1_Silent_p.V41V	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	41					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TCTTCGGGGTCCTGGGCAATG	0.547000													27	77					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57135874	57135874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57135874C>T	ENST00000263314.2	+	10	1000	c.966C>T	c.(964-966)atC>atT	p.I322I		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	322					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						TCCCCACCATCATCAGCTCTG	0.622000													43	162					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196642613	196642613	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196642613G>A	ENST00000312428.6	-	59	11075	c.10975C>T	c.(10975-10977)Cta>Tta	p.L3659L	DNAH7_ENST00000409063.1_Silent_p.L142L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3659					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATTTGTTTAGAATGCTGCGC	0.473000													23	60					0	0	1	0	0
MARS2	92935	broad.mit.edu	37	2	198570227	198570227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:198570227C>T	ENST00000282276.6	+	1	141	c.98C>T	c.(97-99)tCc>tTc	p.S33F	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	33					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	AGTTCGGGCTCCCTCAGTGCC	0.622000													17	60					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38652442	38652442	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:38652442C>T	ENST00000494540.1	+	0	432					NR_003086.1																						TTCATATGTTCTCCACAGCTG	0.428000													15	39					0	0	1	0	0
KAZALD1	81621	broad.mit.edu	37	10	102822738	102822738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102822738C>T	ENST00000370200.5	+	2	715	c.389C>T	c.(388-390)tCg>tTg	p.S130L		NM_030929.4	NP_112191.2	Q96I82	KAZD1_HUMAN	Kazal-type serine peptidase inhibitor domain 1	130	Kazal-like.				cell differentiation|multicellular organismal development|ossification|regulation of cell growth		insulin-like growth factor binding			endometrium(1)|ovary(1)|prostate(2)	4				Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		GCCTGTCGTTCGCAGAGTCCG	0.687000													8	21					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573729	38573729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38573729C>T	ENST00000222345.6	+	3	2033	c.1524C>T	c.(1522-1524)ttC>ttT	p.F508F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	508					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGATTACTTCGTGGGCAAAG	0.622000													22	30					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36330466	36330466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36330466G>A	ENST00000378910.5	-	21	2858	c.2859C>T	c.(2857-2859)acC>acT	p.T953T	NPHS1_ENST00000353632.6_Silent_p.T953T	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	953	Fibronectin type-III.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGGAGTGTGGGGTCAGACTCA	0.557000													21	98					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781919	128781919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128781919C>T	ENST00000529694.1	+	2	1127	c.751C>T	c.(751-753)Ccc>Tcc	p.P251S	KCNJ5_ENST00000338350.4_Missense_Mutation_p.P251S|KCNJ5_ENST00000533599.1_Missense_Mutation_p.P251S	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	251					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	GGAGTTCATCCCCCTGAACCA	0.592000													42	106					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167666583	167666583	+	Missense_Mutation	SNP	G	G	A	rs142342977	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167666583G>A	ENST00000367854.3	+	6	1053	c.722G>A	c.(721-723)aGg>aAg	p.R241K	RCSD1_ENST00000537350.1_Missense_Mutation_p.R211K	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	241	RCSD.									NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CCTCTGAGGAGGTCACCCAGC	0.617000													13	31					0	0	1	0	0
CTRB1	1504	broad.mit.edu	37	16	75258657	75258657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:75258657G>A	ENST00000361017.4	+	7	693	c.685G>A	c.(685-687)Ggc>Agc	p.G229S		NM_001906.4	NP_001897.4			chymotrypsinogen B1											central_nervous_system(1)|lung(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.166)		GACCCTGGTGGGCATTGTGTC	0.647000													19	72					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760756	92760756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92760756C>T	ENST00000318238.4	-	5	5745	c.4529G>A	c.(4528-4530)gGg>gAg	p.G1510E	SAMD9L_ENST00000411955.1_Missense_Mutation_p.G1510E|SAMD9L_ENST00000437805.1_Missense_Mutation_p.G1510E	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1510										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CCACACATCCCCACTGTGCCA	0.418000													41	85					0	0	1	0	0
PRRT2	112476	broad.mit.edu	37	16	29824855	29824855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29824855C>T	ENST00000300797.6	+	2	654	c.480C>T	c.(478-480)ctC>ctT	p.L160L	PRRT2_ENST00000567659.1_Silent_p.L160L|AC009133.20_ENST00000569039.1_RNA|PRRT2_ENST00000358758.7_Silent_p.L160L|PRRT2_ENST00000567551.1_Intron			Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	160	Pro-rich.				response to biotic stimulus	integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						AACCAGAGCTCCCTACCCAGG	0.632000													12	28					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8687402	8687402	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8687402G>A	ENST00000299663.3	-	6	657	c.492C>T	c.(490-492)ttC>ttT	p.F164F	CLEC4E_ENST00000545274.1_Silent_p.F119F|CLEC4E_ENST00000446457.2_3'UTR	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	164	C-type lectin.					integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					CTACATCCCAGAAGCTGAAAA	0.408000													20	53					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38230307	38230307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38230307C>T	ENST00000339503.4	-	8	1411	c.910G>A	c.(910-912)Gag>Aag	p.E304K	ZNF573_ENST00000590414.2_Missense_Mutation_p.E362K|ZNF573_ENST00000536220.1_Missense_Mutation_p.E274K|ZNF573_ENST00000392138.1_Missense_Mutation_p.E275K|ZNF573_ENST00000357309.3_Missense_Mutation_p.E274K	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TTCTTACACTCCTTACATTCA	0.378000													23	94					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42263150	42263150	+	Missense_Mutation	SNP	C	C	T	rs150623766		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42263150C>T	ENST00000361204.4	+	2	570	c.404C>T	c.(403-405)cCc>cTc	p.P135L		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	135	Gln-rich.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						cagccccgcccccagccccag	0.597000													38	71					0	0	1	0	0
SMOC2	64094	broad.mit.edu	37	6	168910679	168910679	+	Missense_Mutation	SNP	G	G	C	rs144833047		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:168910679G>C	ENST00000354536.5	+	2	389	c.169G>C	c.(169-171)Gga>Cga	p.G57R	SMOC2_ENST00000356284.2_Missense_Mutation_p.G57R	NM_022138.2	NP_071421.1	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	57	Kazal-like.				signal transduction	basement membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	32		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CGCATCTGACGGAAGGACCTT	0.463000													38	37					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54420804	54420804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54420804G>A	ENST00000296733.1	-	9	1216	c.1042C>T	c.(1042-1044)Cat>Tat	p.H348Y	CDC20B_ENST00000381375.2_Missense_Mutation_p.H348Y|CDC20B_ENST00000322374.6_Missense_Mutation_p.H348Y|CDC20B_ENST00000334206.5_3'UTR	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	348										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			GTTCCAACATGATGCTGGGCT	0.498000													35	75					0	0	1	0	0
RBM19	9904	broad.mit.edu	37	12	114386804	114386804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:114386804G>A	ENST00000545145.2	-	10	1188	c.1110C>T	c.(1108-1110)gtC>gtT	p.V370V	RBM19_ENST00000261741.5_Silent_p.V370V|RBM19_ENST00000392561.3_Silent_p.V370V	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	370					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TGGTGGTGGGGACGTTCTTTT	0.587000													21	168					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49706729	49706729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:49706729C>T	ENST00000303221.5	-	4	669	c.454G>A	c.(454-456)Gga>Aga	p.G152R	EMB_ENST00000514111.1_Missense_Mutation_p.G102R|EMB_ENST00000506190.1_5'UTR|EMB_ENST00000508934.1_Missense_Mutation_p.G98R	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	152	Ig-like V-type 1.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TTAAATGTTCCCCTTTGTTCC	0.284000													4	51					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38802355	38802355	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38802355G>A	ENST00000359357.3	+	30	3906	c.3651_splice	c.e30-1	p.E1218_splice	DNAH8_ENST00000441566.1_Splice_Site_p.E1218_splice|DNAH8_ENST00000449981.2_Splice_Site_p.E1435_splice					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTCCTTACAGGAAGGACCTAT	0.323000													39	105					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	654295	654295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:654295G>A	ENST00000255622.6	+	12	1550	c.1507G>A	c.(1507-1509)Gaa>Aaa	p.E503K	PDE6B_ENST00000429163.2_Missense_Mutation_p.E224K|PDE6B_ENST00000496514.1_Missense_Mutation_p.E503K	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	503					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						TGACATCTACGAATTCCACTT	0.572000													7	38					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175355212	175355212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175355212C>T	ENST00000367674.1	-	8	2441	c.1733G>A	c.(1732-1734)cGa>cAa	p.R578Q	TNR_ENST00000263525.2_Missense_Mutation_p.R578Q	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	578	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GTTGGTCCCTCGGACGGCACT	0.637000													40	104					0	0	1	0	0
CDK18	5129	broad.mit.edu	37	1	205498689	205498689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205498689C>T	ENST00000360066.2	+	13	1520	c.1219C>T	c.(1219-1221)Ctg>Ttg	p.L407L	CDK18_ENST00000509056.1_3'UTR|CDK18_ENST00000429964.2_Silent_p.L407L|CDK18_ENST00000506784.1_Silent_p.L437L	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	405	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						CAGCCTGCTCCTGGTGAGTGT	0.667000													12	44					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48338023	48338023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48338023C>T	ENST00000435803.1	+	23	9284	c.9260C>T	c.(9259-9261)tCc>tTc	p.S3087F		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3087					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CTTCGCTCTTCCATCCAAATC	0.368000													23	32					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179504001	179504001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179504001G>A	ENST00000367618.3	+	25	3322	c.2935G>A	c.(2935-2937)Gaa>Aaa	p.E979K		NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	979	Glu-rich.									NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						agaagagaaagaaaatcaaga	0.323000													8	71					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227191	38227191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38227191C>T	ENST00000373048.4	-	3	735	c.736G>A	c.(736-738)Ggg>Agg	p.G246R	EPHA10_ENST00000319637.6_Missense_Mutation_p.G246R|EPHA10_ENST00000427468.2_Missense_Mutation_p.G246R	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	246						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCAGGCTCCCCTTCCGAGTGC	0.731000													4	31					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77702315	77702315	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:77702315G>A	ENST00000534064.1	-	2	119	c.85C>T	c.(85-87)Cga>Tga	p.R29*	INTS4_ENST00000529807.1_Nonsense_Mutation_p.R29*|INTS4_ENST00000527522.1_Nonsense_Mutation_p.R29*	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	29					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TTTGTTAGTCGGAGTTTCTTA	0.428000													44	97					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31577468	31577468	+	Missense_Mutation	SNP	C	C	T	rs142997193		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31577468C>T	ENST00000356173.3	-	9	663	c.571G>A	c.(571-573)Gga>Aga	p.G191R	SUN5_ENST00000375523.3_Missense_Mutation_p.G166R	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	191					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						ATGTAATCTCCGTGTATCATC	0.488000													13	57					0	0	1	0	0
FAM227B	196951	broad.mit.edu	37	15	49800440	49800440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:49800440C>T	ENST00000299338.6	-	11	1283	c.980G>A	c.(979-981)aGa>aAa	p.R327K	FAM227B_ENST00000561064.1_Missense_Mutation_p.R293K	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		GTCTGCAATTCTTTCCTTTAC	0.348000													8	123					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40762483	40762483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40762483C>T	ENST00000216194.7	+	13	1468	c.1412C>T	c.(1411-1413)cCa>cTa	p.P471L	ADSL_ENST00000342312.6_Missense_Mutation_p.P412L|RP5-1042K10.13_ENST00000498234.1_RNA|ADSL_ENST00000454266.2_Missense_Mutation_p.P485L	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	471					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						CTGTTAAAACCATATGAAAGC	0.358000													22	49					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100085	110100085	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110100085C>T	ENST00000518632.1	+	2	695	c.344C>T	c.(343-345)tCa>tTa	p.S115L	TRHR_ENST00000311762.2_Missense_Mutation_p.S115L			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	115						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TCCTCTTGTTCAATAACAGCC	0.413000													22	60					0	0	1	0	0
SEC1P	653677	broad.mit.edu	37	19	49183689	49183689	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49183689C>T	ENST00000430145.2	+	0	776					NR_004401.2																						CCGCCACATCCCGGGGCGCTG	0.652000													13	36					0	0	1	0	0
SNTB1	6641	broad.mit.edu	37	8	121561077	121561077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121561077C>T	ENST00000395601.3	-	6	1672	c.1258G>A	c.(1258-1260)Gac>Aac	p.D420N	SNTB1_ENST00000517992.1_Missense_Mutation_p.D420N	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	420	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGGGAGAGGTCCCTGCTGGTC	0.522000													16	61					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72368614	72368614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72368614C>T	ENST00000335666.4	+	4	1312	c.1264C>T	c.(1264-1266)Cgg>Tgg	p.R422W		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	422						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CAAGACTTTCCGGGCCACTGT	0.617000													25	60					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113783888	113783888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:113783888G>A	ENST00000375559.3	+	2	231	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	F10_ENST00000409306.1_Missense_Mutation_p.E65K|F10_ENST00000375551.3_Missense_Mutation_p.E65K|F10_ENST00000483537.1_3'UTR	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	65	Gla.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGCTCATACGAAGAGGCCCG	0.572000													31	91					0	0	1	0	0
OR13J1	392309	broad.mit.edu	37	9	35870088	35870088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35870088C>T	ENST00000377981.2	-	1	373	c.311G>A	c.(310-312)aGc>aAc	p.S104N		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			CGTGGACAGGCTCAGACACAT	0.597000													7	44					0	0	1	0	0
ZNF16	7564	broad.mit.edu	37	8	146156154	146156154	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:146156154G>A	ENST00000276816.4	-	4	2205	c.2019C>T	c.(2017-2019)atC>atT	p.I673I	ZNF16_ENST00000394909.2_Silent_p.I673I	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	673					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		ACTGGTGTTTGATCAACTTTG	0.527000													35	166					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41318367	41318367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41318367C>T	ENST00000551295.2	+	6	526	c.409C>T	c.(409-411)Cct>Tct	p.P137S	CNTN1_ENST00000547849.1_Missense_Mutation_p.P137S|CNTN1_ENST00000547702.1_Missense_Mutation_p.P137S|CNTN1_ENST00000348761.2_Missense_Mutation_p.P126S|CNTN1_ENST00000360099.3_Missense_Mutation_p.P137S|CNTN1_ENST00000347616.1_Missense_Mutation_p.P137S	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	137	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AGATCTTGATCCTTTCCCACC	0.388000													9	20					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152086448	152086448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152086448G>A	ENST00000368804.1	-	1	108	c.109C>T	c.(109-111)Ctt>Ttt	p.L37F		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	37	EF-hand 1.|S-100-like.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCCTTTCAAGGAGGTTCTTC	0.403000													21	125					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38934840	38934840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38934840G>A	ENST00000355481.4	+	6	607	c.476G>A	c.(475-477)gGa>gAa	p.G159E	RYR1_ENST00000359596.3_Missense_Mutation_p.G159E|RYR1_ENST00000360985.3_Missense_Mutation_p.G159E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	159	MIR 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGGTCTGAAGGAGAAAAGGTC	0.602000													26	46					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123901221	123901221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123901221C>T	ENST00000431524.1	+	1	925	c.892C>T	c.(892-894)Ctg>Ttg	p.L298L		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GAAGAAAGCTCTGTTGAAGCT	0.448000													39	78					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18648044	18648044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18648044G>A	ENST00000308799.4	+	1	706	c.487G>A	c.(487-489)Gag>Aag	p.E163K	FBXW10_ENST00000395667.1_Missense_Mutation_p.E163K|FBXW10_ENST00000301938.4_Missense_Mutation_p.E163K|FBXW10_ENST00000395665.4_Missense_Mutation_p.E163K			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	163										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						GTTTCTGAGAGAGGAGAACAA	0.493000													12	34					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143096028	143096028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143096028C>T	ENST00000275815.3	-	6	1088	c.1002G>A	c.(1000-1002)tcG>tcA	p.S334S		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	334	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TTCGGGGGGCCGAGGGGGGAC	0.632000													6	13					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176946975	176946975	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:176946975C>T	ENST00000308618.4	-	2	766	c.630G>A	c.(628-630)gaG>gaA	p.E210E		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	210						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		ACACATAGTTCTCCCGGTAGA	0.662000													9	19					0	0	1	0	0
GBP7	388646	broad.mit.edu	37	1	89618454	89618454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89618454G>A	ENST00000294671.2	-	4	463	c.325C>T	c.(325-327)Cct>Tct	p.P109S		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	109						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TCACTCTTAGGGTCACTCTAG	0.443000													5	58					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181680128	181680128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181680128G>A	ENST00000526775.1	+	8	1259	c.1094G>A	c.(1093-1095)aGg>aAg	p.R365K	CACNA1E_ENST00000367570.1_Missense_Mutation_p.R365K|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R365K|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R316K|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R316K|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R365K	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	365					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GAGAACCGAAGGGCTTTCATG	0.547000													28	91					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897995	175897995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175897995G>A	ENST00000359240.3	+	5	1989	c.1319G>A	c.(1318-1320)gGg>gAg	p.G440E	ADAM29_ENST00000445694.1_Missense_Mutation_p.G440E|ADAM29_ENST00000404450.4_Missense_Mutation_p.G440E|ADAM29_ENST00000514159.1_Missense_Mutation_p.G440E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	440	Disintegrin.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGTGCTTTTGGGCTTTGTTGC	0.448000													16	83					0	0	1	0	0
C9orf9	11092	broad.mit.edu	37	9	135759459	135759459	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135759459C>G	ENST00000372136.3	+	2	572	c.125C>G	c.(124-126)cCc>cGc	p.P42R	C9orf9_ENST00000356311.5_Missense_Mutation_p.P42R|C9orf9_ENST00000350499.6_Missense_Mutation_p.P42R			Q96E40	CI009_HUMAN	chromosome 9 open reading frame 9	42								p.?(1)		cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		AAGATCCGGCCCATCTCCAGC	0.637000													7	53					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94502338	94502338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94502338G>A	ENST00000370225.3	-	26	3906	c.3820C>T	c.(3820-3822)Ctg>Ttg	p.L1274L		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1274					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GTGACCTTCAGAAAAATCTGT	0.428000													24	153					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52569401	52569401	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52569401G>A	ENST00000389534.4	-	7	2193	c.1734C>T	c.(1732-1734)ttC>ttT	p.F578F	ZNF432_ENST00000598446.1_Intron|ZNF841_ENST00000359973.2_Intron|ZNF841_ENST00000594295.1_Silent_p.F578F|ZNF841_ENST00000426391.2_Silent_p.F462F	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						AATAGTAAGTGAAGACCATGC	0.418000													19	82					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84118695	84118695	+	Silent	SNP	G	G	A	rs141095084	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84118695G>A	ENST00000343411.3	-	10	1674	c.1179C>T	c.(1177-1179)acC>acT	p.T393T	MBTPS1_ENST00000569770.1_5'UTR	NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	393	Serine protease.				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CAGCACCATAGGTGACAATGT	0.567000											OREG0023982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	63					0	0	1	0	0
C19orf55	148137	broad.mit.edu	37	19	36255969	36255969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36255969C>T	ENST00000544099.1	+	7	724	c.661C>T	c.(661-663)Ccc>Tcc	p.P221S	C19orf55_ENST00000396908.4_Missense_Mutation_p.P221S			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	221	Ser-rich.									cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCCCTCAGCCCCAGCGATGC	0.627000													56	213					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55045177	55045177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55045177G>A	ENST00000335056.3	+	3	335	c.297G>A	c.(295-297)aaG>aaA	p.K99K																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GAATTTACAAGCACGCCTCAA	0.552000													7	34					0	0	1	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337365	22337365	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22337365C>T	ENST00000390436.2	+	0	179																											CAAACTACTTCCCTTGGTATA	0.438000													56	140					0	0	1	0	0
RASA2	5922	broad.mit.edu	37	3	141295889	141295889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141295889C>T	ENST00000286364.3	+	15	1566	c.1531C>T	c.(1531-1533)Cgt>Tgt	p.R511C	RASA2_ENST00000452898.1_Missense_Mutation_p.R511C			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	511	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						TGTATTTCTTCGTTTCTTTGC	0.358000													53	136					0	0	1	0	0
MRE11A	4361	broad.mit.edu	37	11	94180480	94180480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94180480G>A	ENST00000323929.3	-	15	1910	c.1688C>T	c.(1687-1689)tCa>tTa	p.S563L	MRE11A_ENST00000393241.4_Missense_Mutation_p.S563L|MRE11A_ENST00000323977.3_Missense_Mutation_p.S563L|MRE11A_ENST00000407439.3_Missense_Mutation_p.S566L	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	563					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity	p.S563L(2)		breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				GGTTGCTGCTGAGATGCTATC	0.483000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				73	196					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99827651	99827651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:99827651G>A	ENST00000524871.1	+	8	1077	c.787G>A	c.(787-789)Gat>Aat	p.D263N	CNTN5_ENST00000527185.1_Missense_Mutation_p.D263N|CNTN5_ENST00000528682.1_Missense_Mutation_p.D263N|CNTN5_ENST00000279463.3_Missense_Mutation_p.D263N|CNTN5_ENST00000418526.2_Missense_Mutation_p.D189N	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	263	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCAAACATCAGATGTTGGCAG	0.463000													19	33					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903942	5903942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5903942G>A	ENST00000378961.4	+	4	1356	c.1152G>A	c.(1150-1152)gaG>gaA	p.E384E		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	384						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						GGGATGAGGAGGACAAGAGAA	0.552000													27	125					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325888	31325888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31325888C>T	ENST00000269197.5	+	12	6076	c.6076C>T	c.(6076-6078)Cct>Tct	p.P2026S		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	2026	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						tccccctccccctccaccctt	0.592000													6	11					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73569264	73569264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73569264C>T	ENST00000392550.3	+	20	2747	c.2630C>T	c.(2629-2631)tCg>tTg	p.S877L	LLGL2_ENST00000167462.5_Missense_Mutation_p.S877L|LLGL2_ENST00000577200.1_Missense_Mutation_p.S877L	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	877					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CAGGTGGTCTCGCTGCCCCTG	0.652000													20	54					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038215	75038215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75038215C>T	ENST00000326665.5	-	14	3397	c.3179G>A	c.(3178-3180)cGa>cAa	p.R1060Q	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1060	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AGCTTTCCTTCGCTCTCTTGC	0.428000													71	191					0	0	1	0	0
CEACAM1	634	broad.mit.edu	37	19	43023124	43023124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43023124C>T	ENST00000161559.6	-	5	1356	c.1222G>A	c.(1222-1224)Gac>Aac	p.D408N	CEACAM1_ENST00000358394.3_Intron|CEACAM1_ENST00000352591.5_Intron|LIPE-AS1_ENST00000594688.1_RNA|CEACAM1_ENST00000351134.3_Intron|CEACAM1_ENST00000599389.1_Intron|CEACAM1_ENST00000403461.1_Intron|LIPE-AS1_ENST00000457234.2_RNA|CEACAM1_ENST00000403444.3_Missense_Mutation_p.D408N|CEACAM1_ENST00000308072.4_Intron|LIPE-AS1_ENST00000594624.2_RNA	NM_001712.4	NP_001703.2	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	408	Ig-like C2-type 3.				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	17		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	ATGATGGGGTCGCTTTGGTTC	0.488000													22	125					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87679359	87679359	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87679359G>A	ENST00000320005.5	-	6	693	c.646C>T	c.(646-648)Cga>Tga	p.R216*		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	216					signal transduction|visual perception	integral to membrane	cGMP binding	p.R216*(1)		NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AGATAGAGTCGATCTGGAAAA	0.453000													8	21					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115341719	115341719	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115341719A>T	ENST00000351270.3	+	9	1019	c.923A>T	c.(922-924)gAg>gTg	p.E308V	HABP2_ENST00000542051.1_Missense_Mutation_p.E282V|HABP2_ENST00000541666.1_Intron	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	308					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		GAGATAGCAGAGAGGAAGATC	0.557000													46	124					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316985	30316985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30316985C>T	ENST00000375377.1	-	3	2193	c.2092G>A	c.(2092-2094)Gag>Aag	p.E698K		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	698										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CTTTGGGGCTCCTCGGAGAAA	0.547000													14	46					0	0	1	0	0
SGK2	10110	broad.mit.edu	37	20	42195138	42195138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42195138G>A	ENST00000341458.4	+	1	402	c.183G>A	c.(181-183)atG>atA	p.M61I	SGK2_ENST00000373100.1_Start_Codon_SNP_p.M1I|SGK2_ENST00000423407.3_Start_Codon_SNP_p.M1I|SGK2_ENST00000373092.3_Start_Codon_SNP_p.M1I|SGK2_ENST00000373077.1_Start_Codon_SNP_p.M1I|SGK2_ENST00000426287.1_Missense_Mutation_p.M27I	NM_016276.3	NP_057360.2	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2	61					intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GCTACAGAATGAACTCTAGCC	0.597000													23	82					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457608	45457608	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45457608C>T	ENST00000548424.1	+	0	448																											GTCACTGGTTCTGGATTGGGC	0.502000													18	59					0	0	1	0	0
PPIA	5478	broad.mit.edu	37	7	44839450	44839450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44839450C>T	ENST00000468812.1	+	4	384	c.339C>T	c.(337-339)ttC>ttT	p.F113F	PPIA_ENST00000489459.1_Silent_p.F53F|PPIA_ENST00000355968.6_Silent_p.F53F|PPIA_ENST00000480603.1_3'UTR|PPIA_ENST00000451562.1_Silent_p.F113F	NM_021130.3	NP_066953.1	P62937	PPIA_HUMAN	peptidylprolyl isomerase A (cyclophilin A)	113	PPIase cyclophilin-type.				entry into host cell|leukocyte migration|platelet activation|platelet degranulation|protein folding|provirus integration|regulation of viral genome replication|RNA-dependent DNA replication|uncoating of virus	cytosol|extracellular region|nucleus	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding|virion binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4					Cyclosporine(DB00091)|L-Proline(DB00172)	CCCAGTTTTTCATCTGCACTG	0.468000													39	83					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28710605	28710605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28710605C>T	ENST00000257198.5	-	16	2818	c.2557G>A	c.(2557-2559)Gaa>Aaa	p.E853K	DSC1_ENST00000257197.3_3'UTR|RP11-408H20.2_ENST00000581836.1_RNA	NM_024421.2	NP_077739.1	Q08554	DSC1_HUMAN	desmocollin 1	853					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CCTTTGCCTTCATAGTTATAC	0.428000													55	133					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33140081	33140081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33140081G>A	ENST00000341947.2	-	40	3200	c.2973C>T	c.(2971-2973)ggC>ggT	p.G991G	COL11A2_ENST00000374714.1_Silent_p.G965G|COL11A2_ENST00000361917.1_Silent_p.G884G|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000395197.1_Silent_p.G931G|COL11A2_ENST00000374713.1_Silent_p.G944G|COL11A2_ENST00000374712.1_Silent_p.G910G|COL11A2_ENST00000374708.4_Silent_p.G905G|COL11A2_ENST00000357486.1_Silent_p.G970G	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	991	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TGCCTGGGAGGCCTCTCTCTC	0.632000													3	7					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189912957	189912957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189912957C>T	ENST00000374866.3	-	45	3453	c.3179G>A	c.(3178-3180)cGg>cAg	p.R1060Q		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1060					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AGCACCATCCCGTCCTGGGGT	0.348000													22	55					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	158074137	158074137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:158074137C>T	ENST00000264428.4	+	9	1442	c.1172C>T	c.(1171-1173)aCt>aTt	p.T391I	GLRB_ENST00000541722.1_Intron|GLRB_ENST00000512619.1_Intron|GLRB_ENST00000509282.1_Missense_Mutation_p.T391I	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	391					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GGAACAGGGACTCCTGTTCAT	0.408000													19	39					0	0	1	0	0
EIF4E1B	253314	broad.mit.edu	37	5	176072431	176072431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176072431G>A	ENST00000318682.6	+	8	1112	c.528G>A	c.(526-528)ggG>ggA	p.G176G	EIF4E1B_ENST00000512734.1_3'UTR|EIF4E1B_ENST00000504597.1_Silent_p.G176G	NM_001099408.1	NP_001092878.1	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E family member 1B	176					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			breast(1)|large_intestine(1)|lung(2)|pancreas(1)	5	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGTATGTGGGGCCGTCGTCA	0.617000													14	40					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39432079	39432079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39432079C>T	ENST00000280481.7	+	13	7340	c.7124C>T	c.(7123-7125)cCt>cTt	p.P2375L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2375					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCTTCTGTCCCTCAAATTGTA	0.428000													30	131					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6832146	6832146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6832146C>T	ENST00000304076.2	+	15	1537	c.1443C>T	c.(1441-1443)ggC>ggT	p.G481G	VAV1_ENST00000596764.1_Silent_p.G449G|VAV1_ENST00000539284.1_Silent_p.G384G|VAV1_ENST00000599806.1_Silent_p.G426G|VAV1_ENST00000602142.1_Silent_p.G481G	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	481	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						GTGCCCAGGGCTATGAGCTGT	0.557000													17	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067464	9067464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9067464C>T	ENST00000397910.4	-	3	20185	c.19982G>A	c.(19981-19983)gGa>gAa	p.G6661E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6663	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGCTGGTTCCCTTCAGCCC	0.512000													27	63					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956040	18956040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18956040G>A	ENST00000302797.3	-	1	516	c.292C>T	c.(292-294)Ctc>Ttc	p.L98F	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	98					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ACAGGATAGAGGATTTTAGAG	0.532000													50	139					0	0	1	0	0
H2BFWT	158983	broad.mit.edu	37	X	103267933	103267933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:103267933C>T	ENST00000217926.5	-	1	326	c.300G>A	c.(298-300)cgG>cgA	p.R100R		NM_001002916.3	NP_001002916.2	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	100					nucleosome assembly	nuclear membrane|nucleosome	DNA binding	p.R100R(1)		breast(2)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	16						TCACGGCCTCCCGGGAAAGGC	0.637000													13	18					0	0	1	0	0
OR51I1	390063	broad.mit.edu	37	11	5462037	5462037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5462037C>T	ENST00000380211.1	-	1	707	c.708G>A	c.(706-708)cgG>cgA	p.R236R	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001005288.2	NP_001005288.1	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I, member 1	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGCCTTGAGCCGCTGTTCCT	0.478000													13	32					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63149732	63149732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63149732C>T	ENST00000279178.3	+	6	1305	c.1056C>T	c.(1054-1056)tcC>tcT	p.S352S	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	352					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						AAAGGATCTCCCTCCTGTCCT	0.403000													42	108					0	0	1	0	0
GNG7	2788	broad.mit.edu	37	19	2515055	2515055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2515055G>A	ENST00000382159.3	-	5	369	c.172C>T	c.(172-174)Ccc>Tcc	p.P58S		NM_052847.2	NP_443079.1	O60262	GBG7_HUMAN	guanine nucleotide binding protein (G protein), gamma 7	58					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity			central_nervous_system(2)|large_intestine(1)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTTAAAGGGGTTCTCCGAG	0.493000													34	96					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84564044	84564044	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84564044C>T	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							GCCCAGGGTCCCTACGCATGT	0.532000													14	32					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100192536	100192536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100192536C>T	ENST00000554176.1	+	9	1452	c.786C>T	c.(784-786)ttC>ttT	p.F262F	CYP46A1_ENST00000423126.2_Silent_p.F328F|CYP46A1_ENST00000261835.3_Silent_p.F425F			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	425					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GGCCACGGTTCACCTACTTCC	0.607000													15	47					0	0	1	0	0
CRY1	1407	broad.mit.edu	37	12	107393622	107393622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107393622G>A	ENST00000008527.5	-	7	1711	c.844C>T	c.(844-846)Cct>Tct	p.P282S		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	282	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						GAAAGGGGAGGGGAACTGTTC	0.333000													25	49					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11302087	11302087	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11302087G>A	ENST00000397056.1	+	3	1555	c.1364G>A	c.(1363-1365)tGg>tAg	p.W455*	HRH1_ENST00000431010.2_Nonsense_Mutation_p.W455*|HRH1_ENST00000438284.2_Nonsense_Mutation_p.W455*	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	455					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TTCACCATCTGGCTGGGCTAC	0.453000													41	208					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94044314	94044314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94044314G>A	ENST00000553484.1	+	18	2492	c.2338G>A	c.(2338-2340)Gga>Aga	p.G780R	UNC79_ENST00000555664.1_Missense_Mutation_p.G780R|UNC79_ENST00000256339.4_Missense_Mutation_p.G603R|UNC79_ENST00000393151.2_Missense_Mutation_p.G780R			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	780						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CAAGAATTTTGGACACCCAGG	0.423000													57	122					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060233	54060233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54060233C>T	ENST00000312233.2	-	3	909	c.343G>A	c.(343-345)Ggc>Agc	p.G115S		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	115					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						TTGGAAGGGCCCCCCAGATCT	0.647000													10	51					0	0	1	0	0
TWF1	5756	broad.mit.edu	37	12	44191132	44191132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:44191132G>A	ENST00000395510.2	-	7	862	c.733C>T	c.(733-735)Cat>Tat	p.H245Y	TWF1_ENST00000552521.1_Missense_Mutation_p.H147Y|TWF1_ENST00000548315.1_Missense_Mutation_p.H252Y|TWF1_ENST00000325127.4_Missense_Mutation_p.H279Y	NM_001242397.1|NM_002822.4	NP_001229326.1|NP_002813.3	Q12792	TWF1_HUMAN	twinfilin actin-binding protein 1	245	ADF-H 2.					actin cytoskeleton|cytoplasm	actin binding|protein tyrosine kinase activity			endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|stomach(1)	14	all_cancers(12;0.00125)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.0474)		TCTCCTTCATGGGAATGTTTA	0.333000													13	133					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100549576	100549576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100549576C>T	ENST00000379458.4	+	2	157	c.157C>T	c.(157-159)Ctg>Ttg	p.53_53insL	MUC3A_ENST00000483366.1_3'UTR					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						CTCCAGAGACCTGGCTGGGTG	0.582000													28	131					0	0	1	0	0
CHMP2B	25978	broad.mit.edu	37	3	87302653	87302653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:87302653C>T	ENST00000263780.4	+	5	762	c.524C>T	c.(523-525)tCt>tTt	p.S175F	CHMP2B_ENST00000494980.1_Missense_Mutation_p.S145F|CHMP2B_ENST00000471660.1_Missense_Mutation_p.S134F	NM_014043.3	NP_054762.2	Q9UQN3	CHM2B_HUMAN	charged multivesicular body protein 2B	175					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane|mitochondrion|nucleus	protein domain specific binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	12	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		ATTGAAATTTCTGGAAAGGTA	0.353000													6	53					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78922032	78922032	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78922032G>A	ENST00000261751.3	-	5	726	c.615C>T	c.(613-615)gcC>gcT	p.A205A	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	205					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						TCCCTGGGAGGGCCACTATGT	0.552000													80	97					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104638985	104638985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104638985C>T	ENST00000315264.7	+	6	1361	c.983C>T	c.(982-984)tCc>tTc	p.S328F	KIF26A_ENST00000423312.2_Missense_Mutation_p.S467F			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	467					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		TGCATTTTTTCCTTTGGCCAC	0.632000													19	29					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207135558	207135558	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207135558C>T	ENST00000324852.4	-	5	1126	c.652_splice	c.e5+1	p.G218_splice	FCAMR_ENST00000450945.2_Splice_Site_p.V218_splice|FCAMR_ENST00000400962.3_Splice_Site_p.V218_splice	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	173						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						CAGCTCATACCTGCAGAGATG	0.512000													17	50					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935684	30935684	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30935684C>T	ENST00000355537.3	+	2	1362	c.1215C>T	c.(1213-1215)tcC>tcT	p.S405S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGAACAAGTCCCCCAGCGACC	0.622000													6	57					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3334456	3334456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3334456G>A	ENST00000378398.3	+	12	2838	c.2756G>A	c.(2755-2757)gGc>gAc	p.G919D	PRDM16_ENST00000378391.2_Missense_Mutation_p.G919D|PRDM16_ENST00000442529.2_Missense_Mutation_p.G918D|PRDM16_ENST00000441472.2_Missense_Mutation_p.G918D|PRDM16_ENST00000514189.1_Missense_Mutation_p.G919D|PRDM16_ENST00000511072.1_Missense_Mutation_p.G920D|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Missense_Mutation_p.G919D			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	919	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCGGACTCGGGCAGCTCCCTG	0.602000			T	EVI1	"""MDS, AML"""								38	109					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49167284	49167284	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49167284G>A	ENST00000418109.1	-	11	1557	c.1393C>T	c.(1393-1395)Ctg>Ttg	p.L465L	LAMB2_ENST00000305544.4_Silent_p.L465L	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	465	Laminin EGF-like 3.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGGCAGCCCAGACGGTCACTG	0.572000													30	119					0	0	1	0	0
EXOC6	54536	broad.mit.edu	37	10	94708030	94708030	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:94708030G>A	ENST00000371552.4	+	14	1324		c.e14-1		EXOC6_ENST00000260762.6_Splice_Site|EXOC6_ENST00000443748.2_Splice_Site|EXOC6_ENST00000371547.4_Splice_Site	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6						protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TTTCCTAACAGGGACATTTTT	0.318000													30	45					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170573	90170573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:90170573G>A	ENST00000333209.3	-	2	1207	c.689C>T	c.(688-690)tCt>tTt	p.S230F		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	230										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		CCTCATTTCAGAGTCACAGAT	0.547000													22	52					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16859997	16859997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16859997G>A	ENST00000524140.2	+	6	962	c.544G>A	c.(544-546)Gaa>Aaa	p.E182K	NWD1_ENST00000523826.1_5'UTR|NWD1_ENST00000379808.3_Missense_Mutation_p.E182K|NWD1_ENST00000552788.1_Missense_Mutation_p.E182K|NWD1_ENST00000339803.6_Missense_Mutation_p.E47K|NWD1_ENST00000549814.1_Missense_Mutation_p.E182K	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	182							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AGAGGACCGGGAACAGGGAGC	0.572000													19	48					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25365205	25365205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:25365205C>T	ENST00000330560.3	+	15	3500	c.3023C>T	c.(3022-3024)tCt>tTt	p.S1008F	CDCA2_ENST00000380665.3_Missense_Mutation_p.S993F|CDCA2_ENST00000521098.2_3'UTR	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	1008					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		GGAGAGAGCTCTCTGACTGCC	0.433000													33	90					0	0	1	0	0
FBXO4	26272	broad.mit.edu	37	5	41929924	41929924	+	Missense_Mutation	SNP	C	C	T	rs139473757		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41929924C>T	ENST00000296812.2	+	3	607	c.551C>T	c.(550-552)cCa>cTa	p.P184L	FBXO4_ENST00000281623.3_Missense_Mutation_p.P184L|FBXO4_ENST00000509134.1_Missense_Mutation_p.P184L	NM_033484.2	NP_277019.1	Q9UKT5	FBX4_HUMAN	F-box protein 4	184					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(11)|prostate(1)|stomach(1)|urinary_tract(2)	27		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				ATGTTTGGACCAGGTTTGGAA	0.433000													65	175					0	0	1	0	0
PGD	5226	broad.mit.edu	37	1	10479767	10479767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10479767C>T	ENST00000538557.1	+	13	1618	c.1374C>T	c.(1372-1374)ggC>ggT	p.G458G	PGD_ENST00000270776.8_Silent_p.G471G|PGD_ENST00000541529.1_Silent_p.G449G|PGD_ENST00000498356.1_3'UTR			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	471					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		ACTGGACAGGCCATGGTGGCA	0.547000													16	117					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184298401	184298401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184298401C>T	ENST00000330394.2	+	12	2836	c.2384C>T	c.(2383-2385)tCc>tTc	p.S795F	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	795	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TACACCAGTTCCCTGGTACAG	0.642000													30	66					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10353916	10353916	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10353916G>A	ENST00000255381.2	-	30	4145	c.4035C>T	c.(4033-4035)gaC>gaT	p.D1345D	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1345					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CCCGCAGCAGGTCACAGTCAT	0.532000													39	45					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47423267	47423267	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47423267C>T	ENST00000404338.3	+	1	1335	c.1335C>T	c.(1333-1335)ttC>ttT	p.F445F		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	445	FF 3.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CTTCTCCTTTCATAACTCCCG	0.453000													7	74					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48547612	48547612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48547612G>A	ENST00000435803.1	+	50	13515	c.13491G>A	c.(13489-13491)agG>agA	p.R4497R	ABCA13_ENST00000544596.1_Silent_p.R227R	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4497					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTGGCTACAGGATGTACTGGT	0.488000													8	34					0	0	1	0	0
TRBV30	28557	broad.mit.edu	37	7	142511029	142511029	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142511029G>A	ENST00000417977.2	-	0	55																											CCTCTTCTGGGCCAGTGATGT	0.562000													3	2					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995641	140995641	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140995641C>T	ENST00000285879.4	+	4	2737	c.2451C>T	c.(2449-2451)ttC>ttT	p.F817F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	817							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGCTCCTTCCCCTCCTCCA	0.557000										HNSCC(15;0.026)			85	125					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23928430	23928430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23928430C>T	ENST00000379211.3	+	2	560	c.11C>T	c.(10-12)tCc>tTc	p.S4F		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	4										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						ATGAATCGTTCCTCAAATGTA	0.348000													6	17					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142625187	142625187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142625187C>T	ENST00000265310.1	-	7	1253	c.905G>A	c.(904-906)cGa>cAa	p.R302Q	TRPV5_ENST00000442623.1_Missense_Mutation_p.R302Q	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	302					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CCATACCTCTCGTTTATCAGA	0.522000													13	66					0	0	1	0	0
INTS9	55756	broad.mit.edu	37	8	28695168	28695168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:28695168G>A	ENST00000416984.2	-	4	683	c.324C>T	c.(322-324)acC>acT	p.T108T	INTS9_ENST00000397363.4_Silent_p.T23T|INTS9_ENST00000521777.1_Silent_p.T105T|INTS9_ENST00000521022.1_Silent_p.T129T	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	129					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		CGATCTGGACGGTGGGTTCCG	0.532000													5	30					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218616	130218616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130218616G>A	ENST00000276211.5	+	6	1110	c.765G>A	c.(763-765)ggG>ggA	p.G255G	ARHGAP36_ENST00000370921.1_Silent_p.G119G|ARHGAP36_ENST00000370922.1_Silent_p.G243G	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	255	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GCGCAGTGGGGATTTTTACCC	0.488000													47	43					0	0	1	0	0
FOXR2	139628	broad.mit.edu	37	X	55650496	55650496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:55650496G>A	ENST00000339140.3	+	1	664	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	118					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						ACAAAAAGACGAAGGGTCTAA	0.527000													3	26					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83634662	83634662	+	Silent	SNP	G	G	A	rs138570323	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83634662G>A	ENST00000265362.3	-	11	1667	c.1353C>T	c.(1351-1353)atC>atT	p.I451I	SEMA3A_ENST00000436949.1_Silent_p.I451I	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	451	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						TACCTGTTCCGATAAACATAA	0.358000													20	96					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15452403	15452403	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:15452403C>T	ENST00000341776.2	+	4	734	c.490C>T	c.(490-492)Cga>Tga	p.R164*	JARID2_ENST00000541660.1_Nonsense_Mutation_p.R126*|JARID2_ENST00000397311.3_5'UTR	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	164					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding	p.R164*(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				TCTCTGCCTTCGAGGTAAGAC	0.468000													11	89					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36381037	36381037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36381037C>T	ENST00000373204.4	+	15	2135	c.1922C>T	c.(1921-1923)tCc>tTc	p.S641F	AGO1_ENST00000373206.1_Missense_Mutation_p.S566F	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GAAGACTTGTCCTACATGGTG	0.547000													31	97					0	0	1	0	0
ECT2L	345930	broad.mit.edu	37	6	139175174	139175174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:139175174G>A	ENST00000423192.1	+	9	1242	c.1081G>A	c.(1081-1083)Ggt>Agt	p.G361S	ECT2L_ENST00000541398.1_Missense_Mutation_p.G292S|ECT2L_ENST00000495970.1_3'UTR|ECT2L_ENST00000367682.2_Missense_Mutation_p.G361S			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	361					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.G361C(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						CTATAAAATTGGTGTTAAAAA	0.363000			"""N, Splice, Mis"""		ETP ALL								50	82					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31322989	31322989	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31322989G>A	ENST00000412585.2	-	5	935	c.907C>T	c.(907-909)Cag>Tag	p.Q303*		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						ACGGTGGACTGGGAAGACGGC	0.602000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				24	55					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885620	180885620	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:180885620G>A	ENST00000367588.4	+	2	436	c.381G>A	c.(379-381)ggG>ggA	p.G127G		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	127										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GGAGAGCCGGGACTCCATCAG	0.597000													10	143					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61945235	61945235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61945235G>A	ENST00000422202.1	+	17	2439	c.2371G>A	c.(2371-2373)Gag>Aag	p.E791K	COL20A1_ENST00000326996.6_Missense_Mutation_p.E784K|COL20A1_ENST00000435874.1_Missense_Mutation_p.E791K|COL20A1_ENST00000358894.6_Missense_Mutation_p.E784K			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	784	Fibronectin type-III 6.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CTTGGGACCCGAGAAATCCGT	0.672000													4	32					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79351478	79351478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79351478G>A	ENST00000264895.6	+	37	5316	c.4876G>A	c.(4876-4878)Gcg>Acg	p.A1626T	FRAS1_ENST00000325942.6_Missense_Mutation_p.A1626T	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1625					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGCTGAGACAGCGCCCAAAGA	0.483000													18	46					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19766365	19766365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19766365G>A	ENST00000357324.6	-	10	1394	c.1368C>T	c.(1366-1368)atC>atT	p.I456I	ATP13A1_ENST00000496082.1_5'UTR|ATP13A1_ENST00000291503.5_Silent_p.I338I	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	456	Poly-Ala.				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CAGCTGCAGCGATGGCAAACA	0.607000													18	31					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23522873	23522873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:23522873C>T	ENST00000296682.3	+	8	943	c.761C>T	c.(760-762)cCt>cTt	p.P254L		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	254	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TCAGGCATCCCTCAGGCTGGG	0.582000										HNSCC(3;0.000094)			5	57					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92470193	92470193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92470193G>A	ENST00000267622.4	-	11	4500	c.4127C>T	c.(4126-4128)tCg>tTg	p.S1376L		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1376					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		GGCAGCAATCGAATCAGACAA	0.378000			T	PDGFRB	AML								49	105					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17539531	17539531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17539531C>T	ENST00000229922.2	+	8	1200	c.668C>T	c.(667-669)tCt>tTt	p.S223F	CAP2_ENST00000493172.1_Intron|CAP2_ENST00000465994.1_Missense_Mutation_p.S159F|CAP2_ENST00000489374.1_Missense_Mutation_p.S111F|CAP2_ENST00000378990.2_Missense_Mutation_p.S197F	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	223					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			TCAGCGTTTTCTGTCCTCTCC	0.552000													77	145					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	48098736	48098736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:48098736G>A	ENST00000371741.4	-	1	448	c.282C>T	c.(280-282)tcC>tcT	p.S94S		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	94					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AGTTGAGGATGGAGGTGAAGG	0.597000													12	52					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42778721	42778721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42778721G>A	ENST00000330714.3	+	13	1885	c.1701G>A	c.(1699-1701)atG>atA	p.M567I		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	567					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CAGAAAACATGATCCAACTTC	0.368000													26	74					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2272573	2272573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:2272573G>A	ENST00000290974.2	-	13	2882	c.2543C>T	c.(2542-2544)tCg>tTg	p.S848L	ZFYVE28_ENST00000515312.1_Missense_Mutation_p.S778L|ZFYVE28_ENST00000511071.1_Missense_Mutation_p.S818L|ZFYVE28_ENST00000508471.1_Missense_Mutation_p.S153L	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	848					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GGAGCAGCGCGAGCAGAAGAT	0.657000													4	30					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9434089	9434089	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9434089G>A	ENST00000378501.2	+	29	2955	c.2940G>A	c.(2938-2940)gaG>gaA	p.E980E	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Silent_p.E992E|PLCB4_ENST00000278655.4_Silent_p.E980E|PLCB4_ENST00000378493.1_Silent_p.E980E|PLCB4_ENST00000334005.3_Silent_p.E980E|PLCB4_ENST00000378473.3_Silent_p.E992E	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	980					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AAATCCTAGAGAAGGCAATGA	0.388000													8	76					0	0	1	0	0
LGI3	203190	broad.mit.edu	37	8	22006318	22006318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22006318G>A	ENST00000306317.2	-	8	1291	c.1002C>T	c.(1000-1002)gcC>gcT	p.A334A	LGI3_ENST00000424267.2_Silent_p.A310A	NM_139278.2	NP_644807.1	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	334					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	17				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CGATGCGGAAGGCTTCTAGGT	0.607000													13	32					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73280619	73280619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73280619C>T	ENST00000286657.4	-	4	610	c.574G>A	c.(574-576)Gaa>Aaa	p.E192K		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	192					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCTTTTTCTTCCTCCATCTGT	0.388000													36	85					0	0	1	0	0
RAB4B-EGLN2	100529264	broad.mit.edu	37	19	41292841	41292841	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41292841C>T	ENST00000594136.1	+	7	720	c.615C>T	c.(613-615)gcC>gcT	p.A205A	RAB4B_ENST00000594800.1_Silent_p.A205A|RAB4B-EGLN2_ENST00000601949.1_3'UTR|RAB4B_ENST00000357052.2_Silent_p.A205A														p.A240A(1)									GTGCCCAGGCCGTGGCCCCTC	0.682000													5	52					0	0	1	0	0
ZNF678	339500	broad.mit.edu	37	1	227843293	227843293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:227843293C>T	ENST00000343776.4	+	4	1687	c.1342C>T	c.(1342-1344)Ctt>Ttt	p.L448F	ZNF678_ENST00000397097.3_Missense_Mutation_p.L503F|ZNF678_ENST00000498759.1_Intron			F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	503					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				ATCCTCAATCCTTAGTAAGCA	0.378000													26	78					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55179383	55179383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55179383C>T	ENST00000391736.1	+	14	1575	c.1260C>T	c.(1258-1260)ctC>ctT	p.L420L	LILRB4_ENST00000270452.2_Silent_p.L420L|LILRB4_ENST00000391734.3_Silent_p.L367L|LILRB4_ENST00000391733.3_Silent_p.L421L|LILRB4_ENST00000430952.2_Silent_p.L419L	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	420						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GCTTTACCCTCAGACAGAAGG	0.627000													28	120					0	0	1	0	0
CAMKK2	10645	broad.mit.edu	37	12	121683011	121683011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121683011G>A	ENST00000324774.5	-	15	2313	c.1485C>T	c.(1483-1485)tcC>tcT	p.S495S	CAMKK2_ENST00000347034.2_Silent_p.S452S|CAMKK2_ENST00000538733.1_Silent_p.S452S|CAMKK2_ENST00000402834.4_Silent_p.S495S|CAMKK2_ENST00000446440.2_Silent_p.S452S|CAMKK2_ENST00000545538.1_Silent_p.S282S|CAMKK2_ENST00000337174.3_Silent_p.S495S|CAMKK2_ENST00000412367.2_Silent_p.S495S|CAMKK2_ENST00000392473.2_Silent_p.S495S|CAMKK2_ENST00000392474.2_Silent_p.S495S|CAMKK2_ENST00000404169.3_Silent_p.S495S	NM_006549.3	NP_006540.3	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase kinase 2, beta	495	Calmodulin-binding (By similarity).				calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGTTCCCAAAGGAGCGTTTAC	0.592000													4	5					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143586489	143586489	+	Missense_Mutation	SNP	G	G	A	rs146836865		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:143586489G>A	ENST00000507359.2	+	2	1303	c.212G>A	c.(211-213)gGa>gAa	p.G71E	KCTD16_ENST00000512467.1_Missense_Mutation_p.G71E	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16	71	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			GACTCCAAGGGAAGGTTTTTC	0.463000													12	28					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108872050	108872050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108872050C>T	ENST00000329106.2	+	4	422	c.422C>T	c.(421-423)cCc>cTc	p.P141L	SULT1C3_ENST00000376700.1_Missense_Mutation_p.P141L	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	141						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						GCCAGAAATCCCAAGGATTGC	0.423000													50	114					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180280	124180280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124180280C>T	ENST00000357821.2	-	1	453	c.383G>A	c.(382-384)aGc>aAc	p.S128N		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AAGCAGTGGGCTACAGATGGC	0.498000													6	26					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697719	6697719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6697719C>T	ENST00000245907.6	-	20	2619	c.2527G>A	c.(2527-2529)Gag>Aag	p.E843K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	843					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TCCACCTGCTCGTTTCGAACA	0.587000													41	30					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42285037	42285037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42285037G>A	ENST00000399518.3	-	13	1854	c.1368C>T	c.(1366-1368)ctC>ctT	p.L456L	CTD-2382E5.1_ENST00000499478.2_RNA|PLA2G4E_ENST00000413860.2_Silent_p.L427L	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	444	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GGAATTTGCGGAGCTGGTCTG	0.582000													28	45					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155959	151155959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151155959C>T	ENST00000282466.3	-	6	6389	c.6390G>A	c.(6388-6390)atG>atA	p.M2130I	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2130	Ig-like C2-type 7.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGTGGACCTTCATTTCATCTT	0.443000													14	49					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125083792	125083792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125083792G>A	ENST00000522917.1	+	31	4218	c.4012G>A	c.(4012-4014)Gac>Aac	p.D1338N	FER1L6_ENST00000399018.1_Missense_Mutation_p.D1338N|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1338						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TAGCTCTGAGGACAGCGGGCA	0.507000													16	39					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440711	124440711	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124440711G>A	ENST00000284287.3	+	1	819	c.747G>A	c.(745-747)ggG>ggA	p.G249G		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		CCACAGAGGGGAGATCCAAAG	0.478000													28	89					0	0	1	0	0
DDO	8528	broad.mit.edu	37	6	110714266	110714266	+	Silent	SNP	C	C	T	rs148812598	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110714266C>T	ENST00000368924.3	-	5	837	c.822G>A	c.(820-822)ccG>ccA	p.P274P	DDO_ENST00000368923.3_Silent_p.P215P|DDO_ENST00000368925.1_Silent_p.P246P	NM_003649.2	NP_003640.2	Q99489	OXDD_HUMAN	D-aspartate oxidase	246					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|pancreas(1)|skin(3)	24		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		TTTCTGCATCCGGGGACAGAT	0.522000													52	90					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80714267	80714267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80714267G>A	ENST00000458043.2	+	33	3847	c.3841G>A	c.(3841-3843)Gat>Aat	p.D1281N	OTOGL_ENST00000547103.1_Missense_Mutation_p.D1281N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CCATGACAATGATACTCTTAG	0.448000													9	38					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277759	114277759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114277759C>T	ENST00000357077.4	+	38	8038	c.7985C>T	c.(7984-7986)tCc>tTc	p.S2662F	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.S2629F|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2629					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGGTGTCTTCCTCCTCAGAA	0.478000													22	68					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857825	9857825	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9857825G>A	ENST00000396573.2	-	14	3885	c.3576C>T	c.(3574-3576)acC>acT	p.T1192T	GRIN2A_ENST00000535259.1_Silent_p.T1035T|GRIN2A_ENST00000404927.2_Silent_p.T1192T|GRIN2A_ENST00000562109.1_Silent_p.T1192T|GRIN2A_ENST00000330684.3_Silent_p.T1192T|GRIN2A_ENST00000396575.2_Silent_p.T1192T	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1192					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTCTTTCAAGGTGAAGTGCT	0.542000													127	248					0	0	1	0	0
UGT1A8	54576	broad.mit.edu	37	2	234526842	234526842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234526842C>T	ENST00000373450.4	+	1	552	c.489C>T	c.(487-489)ctC>ctT	p.L163L		NM_019076.4	NP_061949.3														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		ATTTCTCCCTCCCCTCTGTGG	0.453000													63	270					0	0	1	0	0
ATP13A2	23400	broad.mit.edu	37	1	17318748	17318748	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17318748G>A	ENST00000452699.1	-	18	2169	c.1980C>T	c.(1978-1980)aaC>aaT	p.N660N	RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000341676.5_Silent_p.N660N|ATP13A2_ENST00000326735.8_Silent_p.N665N	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	665					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CTGTCTCGGGGTTGCAGAGCC	0.677000													16	25					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27087520	27087520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27087520C>T	ENST00000324856.7	+	5	2465	c.2094C>T	c.(2092-2094)tcC>tcT	p.S698S	ARID1A_ENST00000457599.2_Silent_p.S698S|ARID1A_ENST00000374152.2_Silent_p.S315S	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	698					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTTCCCCGTCCCCTGTTGGCT	0.607000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								29	68					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70079869	70079869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70079869G>A	ENST00000446444.1	-	1	580	c.572C>T	c.(571-573)cCt>cTt	p.P191L	RP11-704M14.1_ENST00000505646.1_RNA|RP11-704M14.1_ENST00000504301.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	191					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						TATGTAGGAAGGAGGGAAAAT	0.403000													14	114					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	166958637	166958637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:166958637C>T	ENST00000392766.2	-	21	2687	c.2347G>A	c.(2347-2349)Gaa>Aaa	p.E783K	ZBBX_ENST00000392764.1_Missense_Mutation_p.E754K|ZBBX_ENST00000455345.2_Missense_Mutation_p.E822K|ZBBX_ENST00000392767.2_Missense_Mutation_p.E783K|ZBBX_ENST00000307529.5_Missense_Mutation_p.E822K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	783	Poly-Glu.					intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AGAAAATCTTCCTCCTCCTCA	0.368000													38	81					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86790910	86790910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86790910G>A	ENST00000441037.2	+	6	492	c.397G>A	c.(397-399)Ggc>Agc	p.G133S	AGBL1_ENST00000421325.2_Missense_Mutation_p.G133S	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	133					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						AGAGTCGAACGGCCGCAGAGC	0.562000													3	16					0	0	1	0	0
MIPEP	4285	broad.mit.edu	37	13	24455909	24455909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:24455909G>A	ENST00000382172.3	-	3	479	c.381C>T	c.(379-381)atC>atT	p.I127I	MIPEP_ENST00000469167.1_5'UTR	NM_005932.3	NP_005923.2	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase	127					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(12)|prostate(2)|skin(1)	27		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CAGGGTGAGCGATTTTCACAA	0.458000													13	34					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110441668	110441668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110441668C>T	ENST00000378402.5	+	26	3204	c.3100C>T	c.(3100-3102)Cgt>Tgt	p.R1034C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1034					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGACCTACTTCGTACACCCAG	0.343000										HNSCC(38;0.096)			5	15					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17373487	17373487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17373487C>T	ENST00000252597.3	-	4	689	c.516G>A	c.(514-516)gaG>gaA	p.E172E	USHBP1_ENST00000598570.1_5'UTR|USHBP1_ENST00000431146.2_Silent_p.E108E	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	172							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						GGCGAGCTGCCTCTCGCTGGC	0.677000													11	114					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	130984581	130984581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130984581C>T	ENST00000341179.7	+	7	1047	c.955C>T	c.(955-957)Cct>Tct	p.P319S	DNM1_ENST00000393594.3_Missense_Mutation_p.P319S|DNM1_ENST00000475805.1_Missense_Mutation_p.P319S|DNM1_ENST00000372923.3_Missense_Mutation_p.P319S|DNM1_ENST00000486160.1_Missense_Mutation_p.P319S	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	319					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						GAACTTCCGCCCTGATGACCC	0.622000													21	31					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111693359	111693359	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111693359G>A	ENST00000431670.2	+	18	4122	c.3711G>A	c.(3709-3711)tgG>tgA	p.W1237*	PHLDB2_ENST00000393923.3_Nonsense_Mutation_p.W1221*|PHLDB2_ENST00000412622.1_Nonsense_Mutation_p.W1194*|PHLDB2_ENST00000393925.3_Nonsense_Mutation_p.W1237*|PHLDB2_ENST00000495180.1_Nonsense_Mutation_p.W728*|PHLDB2_ENST00000481953.1_Nonsense_Mutation_p.W1194*	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	1237	PH.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TGCGGATCTGGATGGATGTTA	0.453000													14	151					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127615	152127615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152127615C>T	ENST00000316073.3	-	3	2024	c.1960G>A	c.(1960-1962)Gat>Aat	p.D654N		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	654	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TGTTGGCTATCCTCTTCAGGC	0.507000													26	89					0	0	1	0	0
ZC4H2	55906	broad.mit.edu	37	X	64139971	64139971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:64139971G>A	ENST00000545618.1	-	4	936	c.373C>T	c.(373-375)Ctt>Ttt	p.L125F	ZC4H2_ENST00000374839.3_Missense_Mutation_p.L130F|ZC4H2_ENST00000447788.2_Missense_Mutation_p.L130F|ZC4H2_ENST00000337990.2_Missense_Mutation_p.L107F|ZC4H2_ENST00000488608.1_5'UTR			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	130							metal ion binding|protein binding			endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TCCAAGGAAAGCTTCTCCTCT	0.522000													6	25					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32158230	32158230	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32158230G>A	ENST00000373672.3	-	15	1643	c.1127C>T	c.(1126-1128)cCg>cTg	p.P376L	COL16A1_ENST00000271069.6_Missense_Mutation_p.P376L|COL16A1_ENST00000373668.3_Missense_Mutation_p.P376L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	376	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTCTCCCTTCGGGCCTTCTGC	0.647000													15	55					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33399952	33399952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33399952C>T	ENST00000418600.2	+	4	411	c.310C>T	c.(310-312)Cgc>Tgc	p.R104C	SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000293748.5_Missense_Mutation_p.R104C|SYNGAP1_ENST00000428982.2_Missense_Mutation_p.R45C	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	104					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						CCACTTGGGTCGCTCGAGGAG	0.632000													16	35					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64643370	64643370	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:64643370C>T	ENST00000587624.1	+	0	777																											CAGAGATATTCGAGAGGCTCT	0.398000													10	45					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46299162	46299162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46299162C>T	ENST00000221538.3	-	6	2261	c.2119G>A	c.(2119-2121)Gag>Aag	p.E707K	RSPH6A_ENST00000597055.1_3'UTR|RSPH6A_ENST00000600188.1_Missense_Mutation_p.E443K	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	707	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						tcctcctcctcgccctcctcc	0.577000													55	86					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183888410	183888410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183888410C>T	ENST00000313143.3	+	15	2266	c.2018C>T	c.(2017-2019)cCc>cTc	p.P673L	EIF2B5_ENST00000444495.1_Intron|DVL3_ENST00000431765.1_Missense_Mutation_p.P656L	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	673					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CCCCCGCCGCCCGCGGCCATG	0.726000													15	20					0	0	1	0	0
F2R	2149	broad.mit.edu	37	5	76029030	76029030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76029030G>A	ENST00000319211.4	+	2	1245	c.980G>A	c.(979-981)gGa>gAa	p.G327E		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	327					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	ATTTGCTTCGGACCCACAAAC	0.512000													34	101					0	0	1	0	0
PDP1	54704	broad.mit.edu	37	8	94935499	94935499	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:94935499C>T	ENST00000396200.3	+	3	1563	c.1287C>T	c.(1285-1287)caC>caT	p.H429H	PDP1_ENST00000517764.1_Silent_p.H404H|PDP1_ENST00000297598.4_Silent_p.H404H|PDP1_ENST00000520728.1_Silent_p.H404H	NM_001161779.1	NP_001155251.1	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 1	404					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18						TAACTTACCACCGATTAAGGC	0.458000													35	107					0	0	1	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	74005167	74005167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:74005167C>T	ENST00000476977.1	+	24	4103	c.2412C>T	c.(2410-2412)ggC>ggT	p.G804G	GTF2IRD1_ENST00000265755.3_Silent_p.G819G|GTF2IRD1_ENST00000424337.2_Silent_p.G804G|GTF2IRD1_ENST00000455841.2_Silent_p.G836G			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	819						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGGCCCTGGGCCTGAACCGGC	0.607000													16	29					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52945952	52945952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52945952C>T	ENST00000295213.4	+	9	1596	c.1222C>T	c.(1222-1224)Cct>Tct	p.P408S	SPATA18_ENST00000419395.2_Missense_Mutation_p.P376S	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	408					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GATTTCATTCCCTCCTGTCGT	0.438000													75	226					0	0	1	0	0
PAEP	5047	broad.mit.edu	37	9	138454150	138454150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138454150C>T	ENST00000479141.1	+	2	151	c.107C>T	c.(106-108)aCc>aTc	p.T36I	PAEP_ENST00000371766.2_Missense_Mutation_p.T36I|PAEP_ENST00000277508.5_Missense_Mutation_p.T36I	NM_002571.2	NP_002562.2	P09466	PAEP_HUMAN	progestagen-associated endometrial protein	36				GTW -> VTA (in Ref. 9; AA sequence).|T -> K (in Ref. 7; AA sequence).	multicellular organismal development	extracellular region	binding|transporter activity			cervix(1)|endometrium(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	6				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		TTGGCAGGGACCTGGCACTCC	0.652000													5	39					0	0	1	0	0
SLC36A3	285641	broad.mit.edu	37	5	150666980	150666980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150666980C>T	ENST00000335230.3	-	6	946	c.535G>A	c.(535-537)Gag>Aag	p.E179K	SLC36A3_ENST00000377713.3_Missense_Mutation_p.E220K	NM_181774.3	NP_861439.3	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3	179						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	21		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTCAGAATCTCCCTGGGCTGG	0.507000													7	67					0	0	1	0	0
CCDC138	165055	broad.mit.edu	37	2	109411018	109411018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:109411018C>T	ENST00000295124.4	+	5	477	c.417C>T	c.(415-417)acC>acT	p.T139T	CCDC138_ENST00000470608.1_3'UTR|CCDC138_ENST00000412964.2_Silent_p.T139T	NM_144978.1	NP_659415.1	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	139										endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	14						CTAATACGACCTCATCGAGAC	0.388000													29	75					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24811299	24811299	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24811299C>T	ENST00000221169.5	-	0	1774							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TCCTCGCCTTCCAAGAGTTTC	0.532000													7	17					0	0	1	0	0
TMEM190	147744	broad.mit.edu	37	19	55889179	55889179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55889179G>A	ENST00000291934.3	+	4	248	c.230G>A	c.(229-231)cGg>cAg	p.R77Q	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	77						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GAAAACGTGCGGAGGAAGCAC	0.677000													6	47					0	0	1	0	0
MIR522	574495	broad.mit.edu	37	19	54254478	54254478	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54254478C>T	ENST00000385071.1	+	0	14					NR_030217.1																						CAGGCTGTGTCCCTCTAGAGG	0.413000													51	119					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497178	1497178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1497178C>T	ENST00000421627.2	+	2	453	c.319C>T	c.(319-321)Cgc>Tgc	p.R107C		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	186					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CAAGATCAACCGCATCCCGGC	0.682000													11	13					0	0	1	0	0
TRBC2	28638	broad.mit.edu	37	7	142498732	142498732	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142498732G>A	ENST00000466254.1	+	0	8																											CAGAGGACCTGAAAAACGTGT	0.562000													18	57					0	0	1	0	0
GALNT7	51809	broad.mit.edu	37	4	174169386	174169386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:174169386C>T	ENST00000265000.4	+	2	465	c.382C>T	c.(382-384)Cgc>Tgc	p.R128C	GALNT7_ENST00000512285.1_Missense_Mutation_p.R128C	NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	128					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		TCCTGTGCTTCGCCCAGGGAT	0.512000													32	61					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44797655	44797655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44797655C>T	ENST00000309315.4	+	6	884	c.761C>T	c.(760-762)cCt>cTt	p.P254L	ZMIZ2_ENST00000441627.1_Missense_Mutation_p.P254L|ZMIZ2_ENST00000433667.1_Missense_Mutation_p.P222L|ZMIZ2_ENST00000413916.1_Missense_Mutation_p.P222L|ZMIZ2_ENST00000265346.7_Missense_Mutation_p.P254L	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	254	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TATCCTGGGCCTCCCCAGGCC	0.632000													36	95					0	0	1	0	0
MIR551B	693136	broad.mit.edu	37	3	168269701	168269701	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168269701G>A	ENST00000384984.1	+	0	60					NR_030294.1																						AGAACGGGAAGGCGACCCATA	0.453000													15	49					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55143862	55143862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:55143862C>T	ENST00000491143.2	+	2	1454	c.1422C>T	c.(1420-1422)ttC>ttT	p.F474F		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	474					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		GCAACTTCTTCATGAACGCCC	0.577000													13	71					0	0	1	0	0
IL17B	27190	broad.mit.edu	37	5	148756469	148756469	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148756469C>T	ENST00000261796.3	-	2	191	c.141G>A	c.(139-141)ctG>ctA	p.L47L	IL17B_ENST00000505432.1_5'UTR	NM_014443.2	NP_055258.1	Q9UHF5	IL17B_HUMAN	interleukin 17B	47					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)|urinary_tract(1)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACCAGGTCCAGTGGCACCT	0.652000													30	81					0	0	1	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60027228	60027228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:60027228G>A	ENST00000586569.1	+	6	600	c.562G>A	c.(562-564)Gag>Aag	p.E188K	TNFRSF11A_ENST00000269485.7_Missense_Mutation_p.E188K	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	188					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				TCATGGGACAGAGAAATCCGA	0.433000													27	70					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38451527	38451527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38451527C>T	ENST00000322350.5	+	19	3000	c.2654C>T	c.(2653-2655)tCc>tTc	p.S885F	EGFLAM_ENST00000397210.3_Missense_Mutation_p.S28F|EGFLAM_ENST00000336740.6_Missense_Mutation_p.S651F|EGFLAM_ENST00000514476.1_Missense_Mutation_p.S28F|EGFLAM_ENST00000506135.1_Missense_Mutation_p.S28F|EGFLAM_ENST00000397202.2_Missense_Mutation_p.S251F|EGFLAM_ENST00000354891.3_Missense_Mutation_p.S893F	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	893	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GACTTCATTTCCTTGGGCCTT	0.517000													37	102					0	0	1	0	0
KRT6C	286887	broad.mit.edu	37	12	52865921	52865921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52865921G>A	ENST00000252250.6	-	2	731	c.684C>T	c.(682-684)atC>atT	p.I228I		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	228	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GTTCCCCGACGATGCTGTCCA	0.597000													42	132					0	0	1	0	0
BAAT	570	broad.mit.edu	37	9	104125001	104125001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104125001G>A	ENST00000259407.2	-	4	1074	c.966C>T	c.(964-966)ttC>ttT	p.F322F	BAAT_ENST00000395051.3_Silent_p.F322F	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	322					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	CTCCTACAATGAAGAGGAATT	0.468000													32	94					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187003942	187003942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187003942C>T	ENST00000296795.2	+	4	1206	c.1102C>T	c.(1102-1104)Cca>Tca	p.P368S	TLR3_ENST00000504367.1_Missense_Mutation_p.P91S	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	368					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TAATGATATTCCAGGCATAAA	0.343000													15	36					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286905	152286905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152286905C>T	ENST00000368799.1	-	3	492	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	153					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAACTAGATTCATGCCTTTTC	0.348000									Ichthyosis				17	130					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16977298	16977298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16977298C>T	ENST00000379803.1	+	13	1847	c.1833C>T	c.(1831-1833)ttC>ttT	p.F611F	SIN3B_ENST00000248054.5_Silent_p.F579F|SIN3B_ENST00000595541.1_Silent_p.F169F	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	611					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						CTGTGAACTTCAAGCAGAACG	0.597000													26	84					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751374	26751374	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:26751374C>T	ENST00000396641.2	+	2	803	c.211C>T	c.(211-213)Ctg>Ttg	p.L71L	LRRC3B_ENST00000456208.2_Silent_p.L71L|LRRC3B_ENST00000417744.1_Silent_p.L71L	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	71						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						CTTACTGTATCTGGACTCCAA	0.403000													16	49					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7989454	7989454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7989454G>A	ENST00000319144.4	-	2	492	c.232C>T	c.(232-234)Ccc>Tcc	p.P78S		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	78	PLAT.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						GGGTCCTTGGGGAAGAAGGCG	0.592000										Multiple Myeloma(8;0.094)			24	26					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69817226	69817226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69817226C>T	ENST00000251566.4	-	1	283	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K		NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	85						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TCATTTTCTTCTGTTCTGTCC	0.368000													22	67					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98209303	98209303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:98209303G>A	ENST00000430669.2	-	23	4622	c.4037C>T	c.(4036-4038)cCc>cTc	p.P1346L	PTCH1_ENST00000421141.1_Missense_Mutation_p.P1261L|PTCH1_ENST00000331920.6_Missense_Mutation_p.P1412L|PTCH1_ENST00000429896.2_Missense_Mutation_p.P1261L|PTCH1_ENST00000418258.1_Missense_Mutation_p.P1261L|PTCH1_ENST00000375274.2_Missense_Mutation_p.P1411L|PTCH1_ENST00000437951.1_Missense_Mutation_p.P1346L			Q13635	PTC1_HUMAN	patched 1	1412					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AGGCACGTGGGGGTCCTCAAA	0.672000													9	96					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100594366	100594366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100594366C>T	ENST00000471714.1	-	8	933	c.824G>A	c.(823-825)gGa>gAa	p.G275E	ABI3BP_ENST00000495063.1_Missense_Mutation_p.G275E|ABI3BP_ENST00000284322.5_Missense_Mutation_p.G275E			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	275						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TATCACTCCTCCCAGTGGAGC	0.438000													15	51					0	0	1	0	0
SAMSN1	64092	broad.mit.edu	37	21	15858288	15858288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:15858288G>A	ENST00000285670.2	-	9	1445	c.1271C>T	c.(1270-1272)tCt>tTt	p.S424F	SAMSN1_ENST00000400564.1_Missense_Mutation_p.S188F|SAMSN1_ENST00000400566.1_Missense_Mutation_p.S356F	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	356					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CAGATTTTCAGACTCCAGATC	0.393000													30	140					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38281580	38281580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:38281580C>T	ENST00000553443.1	+	25	4631	c.4631C>T	c.(4630-4632)aCc>aTc	p.T1544I	TTC6_ENST00000267368.7_Missense_Mutation_p.T178I|TTC6_ENST00000382320.3_Missense_Mutation_p.T258I|TTC6_ENST00000476979.1_Missense_Mutation_p.T178I					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		AAACTAAATACCTTCCTTAAT	0.368000													31	82					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43552311	43552311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43552311C>T	ENST00000220420.5	-	3	382	c.375G>A	c.(373-375)caG>caA	p.Q125Q	TGM5_ENST00000349114.4_Intron	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	125					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TCACAGACCCCTGGAAGGAGT	0.612000													53	75					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38753835	38753835	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38753835G>A	ENST00000449082.2	-	22	3905	c.3906C>T	c.(3904-3906)ctC>ctT	p.L1302L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1302					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCCCTGCGAAGAGGTTCACAC	0.493000													30	154					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100999520	100999520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100999520C>T	ENST00000325455.5	-	1	1735	c.282G>A	c.(280-282)agG>agA	p.R94R	PGR_ENST00000263463.5_Silent_p.R94R|PGR_ENST00000534013.1_Intron	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	94	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CTCCAGCACCCCTTGTAGCTT	0.632000													14	46					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90016011	90016011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90016011G>A	ENST00000405460.2	+	44	9690	c.9594G>A	c.(9592-9594)ggG>ggA	p.G3198G		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3198					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCCCTTTGGGGCTATTCAGTA	0.368000													17	19					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439312	110439312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110439312G>A	ENST00000378402.5	+	25	3031	c.2927G>A	c.(2926-2928)cGa>cAa	p.R976Q		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	976					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCAGTTACACGAGAGGGAACC	0.542000										HNSCC(38;0.096)			11	62					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46094150	46094150	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46094150G>A	ENST00000323040.4	-	2	1919	c.975C>T	c.(973-975)acC>acT	p.T325T	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	325						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		AGGTGAGTGGGGTCTCCAGGG	0.662000													11	93					0	0	1	0	0
RNF220	55182	broad.mit.edu	37	1	44878220	44878220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44878220C>T	ENST00000355387.2	+	2	901	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	RNF220_ENST00000361799.2_Missense_Mutation_p.P151S|RNF220_ENST00000372247.2_Missense_Mutation_p.P151S			Q5VTB9	RN220_HUMAN	ring finger protein 220	151					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						CACAGAGTCTCCCCACTTGCG	0.562000													40	88					0	0	1	0	0
GABRD	2563	broad.mit.edu	37	1	1961512	1961512	+	Missense_Mutation	SNP	C	C	T	rs79386457	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1961512C>T	ENST00000378585.4	+	9	1233	c.1150C>T	c.(1150-1152)Ccg>Tcg	p.P384S		NM_000815.4	NP_000806.2	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	384						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GCGCCGCGTCCCGGGGAACCT	0.687000													14	38					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10080036	10080036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10080036G>A	ENST00000264828.3	-	57	4226	c.4141C>T	c.(4141-4143)Cct>Tct	p.P1381S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1381	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			AGGGGGCCAGGAGGGCCCATC	0.597000													18	47					0	0	1	0	0
B3GNT2	10678	broad.mit.edu	37	2	62449618	62449618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:62449618C>T	ENST00000301998.4	+	2	515	c.263C>T	c.(262-264)tCc>tTc	p.S88F	B3GNT2_ENST00000405767.1_Missense_Mutation_p.S88F	NM_006577.5	NP_006568.2	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	88						Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)	18	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			GGCAGGCTCTCCAATATAAGC	0.547000													163	404					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25675929	25675929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25675929C>T	ENST00000382051.3	+	11	1278	c.1228C>T	c.(1228-1230)Ccc>Tcc	p.P410S	SLC34A2_ENST00000503434.1_Missense_Mutation_p.P409S|SLC34A2_ENST00000504570.1_Missense_Mutation_p.P409S	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	410					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TTTCCCCTTTCCCTTTGCATG	0.597000			T	ROS1	NSCLC								18	34					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126400967	126400967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126400967C>T	ENST00000394329.3	+	14	12558	c.12545C>T	c.(12544-12546)tCa>tTa	p.S4182L	FAT4_ENST00000335110.5_Intron	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4182	EGF-like 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GATTACTGGTCATGGCAGCAG	0.428000													17	34					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310133	57310133	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57310133G>A	ENST00000457912.1	+	2	72	c.72G>A	c.(70-72)ggG>ggA	p.G24G	SMTNL1_ENST00000399154.2_Silent_p.G6G|SMTNL1_ENST00000527972.1_Silent_p.G6G			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	6										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						AGAAGGAAGGGAAGCTCTCTG	0.597000													6	26					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216007	140216007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140216007C>T	ENST00000525929.1	+	1	2039	c.2039C>T	c.(2038-2040)tCg>tTg	p.S680L	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.S680L|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGCGTCGTCGCGGGCATCG	0.627000													28	102					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83433134	83433134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:83433134C>T	ENST00000296591.5	-	5	812	c.394G>A	c.(394-396)Gga>Aga	p.G132R	EDIL3_ENST00000380138.3_Missense_Mutation_p.G122R	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	132	EGF-like 3.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GTACATATTCCACCATTTTTG	0.358000													51	115					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2622075	2622075	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2622075G>T	ENST00000399655.1	+	9	1580	c.1315G>T	c.(1315-1317)Gat>Tat	p.D439Y	CACNA1C_ENST00000347598.4_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399591.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000480911.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000344100.3_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399597.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000335762.5_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399595.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399603.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399617.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399606.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399621.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399601.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399638.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399649.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399644.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399629.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000327702.7_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399634.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399637.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000406454.3_Missense_Mutation_p.D439Y|CACNA1C_ENST00000402845.3_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399641.1_Missense_Mutation_p.D439Y	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	439	Binding to the beta subunit (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGGCTACCTGGATTGGATCAC	0.537000													6	14					0.00116845	0.00116965	1	1	0
COL14A1	7373	broad.mit.edu	37	8	121262978	121262978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121262978G>A	ENST00000297848.3	+	22	2995	c.2725G>A	c.(2725-2727)Gac>Aac	p.D909N	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.D909N|COL14A1_ENST00000247781.3_Missense_Mutation_p.D814N	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	909	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AGGCTTCAGCGACGCCCTGAC	0.478000													10	47					0	0	1	0	0
WNT1	7471	broad.mit.edu	37	12	49373260	49373260	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49373260G>A	ENST00000293549.3	+	2	150	c.114G>A	c.(112-114)gtG>gtA	p.V38V		NM_005430.3	NP_005421.1	P04628	WNT1_HUMAN	wingless-type MMTV integration site family, member 1	38					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(357;0.244)		GGGGTATTGTGAACGTAGCCT	0.567000													44	101					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113953812	113953812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113953812G>A	ENST00000245796.6	+	12	2509	c.2314G>A	c.(2314-2316)Gat>Aat	p.D772N	PSD4_ENST00000441564.2_Missense_Mutation_p.D744N	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	772					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCTGGCTCAGGATCCCACAGT	0.567000													16	45					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72345460	72345460	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72345460G>A	ENST00000389916.4	+	10	1323	c.1185G>A	c.(1183-1185)caG>caA	p.Q395Q		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	395					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GGGGCCGGCAGGATCGGGGTG	0.662000													12	17					0	0	1	0	0
KRTAP10-7	386675	broad.mit.edu	37	21	46021535	46021535	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46021535C>T	ENST00000380102.2	+	1	1039	c.1014C>T	c.(1012-1014)tcC>tcT	p.S338S	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	338	30 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						CCCCCACCTCCTCCTGCCAGG	0.716000													22	69					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74943984	74943984	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74943984A>G	ENST00000569840.2	+	17	2570	c.1996A>G	c.(1996-1998)Aat>Gat	p.N666D	MGAT5B_ENST00000301618.4_Missense_Mutation_p.N664D|MGAT5B_ENST00000428789.2_Missense_Mutation_p.N675D	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	666						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCTGGCCCCCAATGCCACCCA	0.711000													8	25					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85401165	85401165	+	Missense_Mutation	SNP	C	C	T	rs139722212		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85401165C>T	ENST00000258888.5	+	6	3969	c.3802C>T	c.(3802-3804)Ccc>Tcc	p.P1268S		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1268					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGGTCCTGGTCCCAGCTCCCT	0.687000													6	19					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152057759	152057759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152057759G>A	ENST00000368806.1	-	3	2463	c.2399C>T	c.(2398-2400)cCa>cTa	p.P800L		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	800							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CTGGTATAGTGGACTGGAATA	0.488000													50	123					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595325	140595325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140595325G>A	ENST00000341948.4	+	1	1817	c.1630G>A	c.(1630-1632)Gag>Aag	p.E544K		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		544	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGAGCAGCGAGGCGCTGGT	0.701000													32	71					0	0	1	0	0
PLS1	5357	broad.mit.edu	37	3	142405204	142405204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142405204C>T	ENST00000337777.3	+	9	1180	c.967C>T	c.(967-969)Ctt>Ttt	p.L323F	PLS1_ENST00000497002.1_Missense_Mutation_p.L323F|PLS1_ENST00000457734.2_Missense_Mutation_p.L323F	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	323	Actin-binding 1.|CH 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						TGCCATTGACCTTTCAGGAAT	0.348000													28	118					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41979410	41979410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:41979410C>T	ENST00000372584.1	-	7	6496	c.5482G>A	c.(5482-5484)Gac>Aac	p.D1828N	HIVEP3_ENST00000429157.2_Missense_Mutation_p.D1828N|HIVEP3_ENST00000372583.1_Missense_Mutation_p.D1828N|HIVEP3_ENST00000247584.5_Missense_Mutation_p.D1828N|HIVEP3_ENST00000460604.1_5'UTR	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1828	Acidic 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGAACAGGTCGTCACTGGTT	0.597000													9	33					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196295998	196295998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196295998C>T	ENST00000367433.5	-	19	2226	c.2125G>A	c.(2125-2127)Gag>Aag	p.E709K	KCNT2_ENST00000498426.1_Intron|KCNT2_ENST00000367431.4_Missense_Mutation_p.E659K|KCNT2_ENST00000294725.8_Missense_Mutation_p.E709K|KCNT2_ENST00000451324.2_Missense_Mutation_p.E320K			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	709						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TTTGCATCCTCATAGTAGTTA	0.318000													42	102					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116073768	116073768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116073768C>T	ENST00000369271.3	-	7	954	c.654G>A	c.(652-654)gtG>gtA	p.V218V	AFAP1L2_ENST00000304129.4_Silent_p.V218V|AFAP1L2_ENST00000545353.1_Silent_p.V271V	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	218	PH 1.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		CCAGTAGGTTCACGTCCAGCT	0.552000													18	57					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196716443	196716443	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196716443G>A	ENST00000367429.4	+	22	3936	c.3696G>A	c.(3694-3696)taG>taA	p.*1232*		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	0					complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						CAAAAAGATAGAATCAATCAT	0.338000													20	56					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116198974	116198974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116198974C>T	ENST00000533213.2	-	21	2224	c.1923G>A	c.(1921-1923)atG>atA	p.M641I	ABLIM1_ENST00000369253.2_Missense_Mutation_p.M324I|ABLIM1_ENST00000369266.3_Missense_Mutation_p.M378I|ABLIM1_ENST00000277895.5_Missense_Mutation_p.M701I|ABLIM1_ENST00000392952.3_Missense_Mutation_p.M378I|ABLIM1_ENST00000369252.4_Missense_Mutation_p.M641I			O14639	ABLM1_HUMAN	actin binding LIM protein 1	701					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CTCCTCGGTCCATTCTCATTG	0.473000													18	55					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130501159	130501159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130501159C>T	ENST00000314830.8	-	12	2562	c.2449G>A	c.(2449-2451)Gag>Aag	p.E817K	SH2D3C_ENST00000420366.1_Missense_Mutation_p.E659K|SH2D3C_ENST00000373274.3_Missense_Mutation_p.E657K|SH2D3C_ENST00000373276.3_Missense_Mutation_p.E749K|SH2D3C_ENST00000373277.4_Missense_Mutation_p.E660K|SH2D3C_ENST00000429553.1_Missense_Mutation_p.E463K	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	817	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						ATCTGGAACTCCGTGCTGAAC	0.647000													4	8					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46094548	46094548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46094548G>A	ENST00000323040.4	-	2	1521	c.577C>T	c.(577-579)Ccg>Tcg	p.P193S	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	193						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		AGCGCCCACGGGAAGAGGAAG	0.642000													15	62					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100373312	100373312	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100373312C>T	ENST00000542585.1	+	0	6194				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACAGGTCACCCTCCCCGCCAT	0.567000													16	59					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154414531	154414531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:154414531C>T	ENST00000229768.5	+	4	1341	c.1291C>T	c.(1291-1293)Cgt>Tgt	p.R431C	OPRM1_ENST00000435918.2_Intron|OPRM1_ENST00000522236.1_Intron|OPRM1_ENST00000524163.1_Intron|OPRM1_ENST00000452687.2_Intron|OPRM1_ENST00000330432.7_Intron|OPRM1_ENST00000360422.4_Intron|OPRM1_ENST00000434900.2_Intron|OPRM1_ENST00000520708.1_Intron|OPRM1_ENST00000337049.4_Intron|OPRM1_ENST00000518759.1_Intron|OPRM1_ENST00000419506.2_Intron|OPRM1_ENST00000522555.1_Intron|OPRM1_ENST00000414028.2_Intron	NM_001008505.1	NP_001008505.2	P35372	OPRM_HUMAN	opioid receptor, mu 1	0					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	GTCCTGCCTTCGTGGAAATAC	0.527000													43	146					0	0	1	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15444301	15444301	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:15444301T>A	ENST00000295297.4	+	3	1028	c.769T>A	c.(769-771)Ttc>Atc	p.F257I	C1QTNF7_ENST00000429690.1_Missense_Mutation_p.F250I|C1QTNF7_ENST00000444304.2_Missense_Mutation_p.F250I	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	250	C1q.					collagen				endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						GCTGGAGATTTTCTTCACAGA	0.493000													54	94					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42458807	42458807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42458807G>A	ENST00000318006.5	-	15	1722	c.1560C>T	c.(1558-1560)tcC>tcT	p.S520S	VPS39_ENST00000348544.4_Silent_p.S531S	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	531					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		CTTTCAGAGGGGAGTTGGCTT	0.547000													21	51					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47379846	47379846	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47379846T>A	ENST00000285039.7	-	31	4493	c.4194A>T	c.(4192-4194)gaA>gaT	p.E1398D	MYO5B_ENST00000324581.6_Missense_Mutation_p.E513D	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1398					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GCCGGGATATTTCCTGCTGAA	0.567000													20	67					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107938511	107938511	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107938511G>A	ENST00000328300.6	+	52	5080	c.4836G>A	c.(4834-4836)ggG>ggA	p.G1612G	COL4A5_ENST00000361603.2_Silent_p.G1606G	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1606	Collagen IV NC1.		Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CAAGTGCAGGGGCAGAAGGCT	0.493000									Alport syndrome with Diffuse Leiomyomatosis				16	77					0	0	1	0	0
CXCL12	6387	broad.mit.edu	37	10	44873247	44873247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:44873247G>A	ENST00000395794.2	-	4	416	c.373C>T	c.(373-375)Cgt>Tgt	p.R125C	CXCL12_ENST00000395795.4_Intron|CXCL12_ENST00000374426.2_Intron|CXCL12_ENST00000395793.3_Intron|CXCL12_ENST00000374429.2_Intron|CXCL12_ENST00000343575.6_3'UTR	NM_001178134.1	NP_001171605.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	0					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	GGCCAAAGACGGATCTCACAG	0.612000													8	19					0	0	1	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98677961	98677961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:98677961C>T	ENST00000288985.7	+	5	1138	c.833C>T	c.(832-834)tCa>tTa	p.S278L	ERCC6L2_ENST00000466840.1_3'UTR|ERCC6L2_ENST00000437817.1_Missense_Mutation_p.S89L	NM_001010895.2	NP_001010895.1	Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	278	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										TTGGAATGGTCAGCTGTCATT	0.363000													17	96					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17789545	17789545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:17789545G>A	ENST00000380607.4	+	6	741	c.621G>A	c.(619-621)atG>atA	p.M207I	SH3GL2_ENST00000537391.1_Missense_Mutation_p.M160I	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	207	BAR.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		TCTTGGAGATGGATGTAAGTG	0.373000													11	72					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801491	185801491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185801491C>T	ENST00000302277.6	+	4	1962	c.1368C>T	c.(1366-1368)agC>agT	p.S456S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	456						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTTCCTATAGCTGTAATCCTC	0.353000													40	108					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33920725	33920725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33920725C>T	ENST00000389232.4	+	21	2698	c.2628C>T	c.(2626-2628)atC>atT	p.I876I	RYR3_ENST00000415757.3_Silent_p.I876I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	876	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGAAAACATCCATGAGCTTT	0.443000													17	67					0	0	1	0	0
ANKRD10	55608	broad.mit.edu	37	13	111546503	111546503	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111546503G>A	ENST00000375758.5	-	4	636	c.502C>T	c.(502-504)Caa>Taa	p.Q168*	ANKRD10_ENST00000267339.2_Intron|ANKRD10_ENST00000310847.4_Nonsense_Mutation_p.Q168*|ANKRD10_ENST00000489973.2_5'UTR			Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	0										central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)	9	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			ACTCCATGTTGAAGTTCCCCT	0.383000													36	88					0	0	1	0	0
IFNA14	3448	broad.mit.edu	37	9	21239751	21239751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21239751G>A	ENST00000380222.2	-	1	227	c.184C>T	c.(184-186)Ccc>Tcc	p.P62S		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	62					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TCCTCCTGGGGAAATTCAAAG	0.468000													67	106					0	0	1	0	0
PWWP2B	170394	broad.mit.edu	37	10	134218356	134218356	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134218356C>T	ENST00000305233.5	+	2	411	c.352C>T	c.(352-354)Cct>Tct	p.P118S	PWWP2B_ENST00000368609.4_Missense_Mutation_p.P118S	NM_138499.3	NP_612508.3	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2B	118	Pro-rich.									central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GCCCCCGTACCCTCCCTACTT	0.756000													17	20					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131186724	131186724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:131186724G>A	ENST00000337057.3	-	17	2962	c.2781C>T	c.(2779-2781)acC>acT	p.T927T	EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000528282.1_Silent_p.T669T|EPB41L2_ENST00000525193.1_Silent_p.T628T|EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000527659.1_Silent_p.T733T|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000445890.2_Silent_p.T669T|EPB41L2_ENST00000368128.2_Silent_p.T927T|EPB41L2_ENST00000527411.1_Silent_p.T857T|EPB41L2_ENST00000530481.1_Silent_p.T774T|EPB41L2_ENST00000531410.1_Silent_p.T48T|EPB41L2_ENST00000529208.1_Silent_p.T857T|EPB41L2_ENST00000524581.1_Silent_p.T305T	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	927	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CAGATGTGATGGTTTGTGCGG	0.458000													19	47					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327032	52327032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52327032G>A	ENST00000339223.4	+	2	210	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K	FPR3_ENST00000595991.1_Missense_Mutation_p.E11K	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	11					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TCCTCTGAATGAAACTGAGGA	0.493000													22	42					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12483637	12483637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:12483637G>A	ENST00000535902.1	-	4	1183	c.620C>T	c.(619-621)tCa>tTa	p.S207L	MANSC1_ENST00000396349.3_Missense_Mutation_p.S173L|MANSC1_ENST00000545735.1_Missense_Mutation_p.S126L			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	207						integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		GGAAAATTGTGAACTCTGAGA	0.463000													20	51					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34125657	34125657	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34125657G>A	ENST00000297161.2	+	14	2072	c.1698G>A	c.(1696-1698)tgG>tgA	p.W566*	BMPER_ENST00000426693.1_Nonsense_Mutation_p.W566*	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	566	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						TCAAATCCTGGGAGTTTCAGA	0.502000													22	56					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3342181	3342181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3342181G>A	ENST00000378398.3	+	14	3058	c.2976G>A	c.(2974-2976)tcG>tcA	p.S992S	PRDM16_ENST00000378391.2_Silent_p.S992S|PRDM16_ENST00000442529.2_Silent_p.S991S|PRDM16_ENST00000441472.2_Silent_p.S991S|PRDM16_ENST00000514189.1_Silent_p.S992S|PRDM16_ENST00000511072.1_Silent_p.S993S|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Silent_p.S992S			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	992	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCATCTCTTCGAACCTCCAGC	0.632000			T	EVI1	"""MDS, AML"""								35	76					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135429948	135429948	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135429948G>A	ENST00000394143.1	+	6	4374	c.4083G>A	c.(4081-4083)ggG>ggA	p.G1361G	GPR112_ENST00000370652.1_Silent_p.G1361G|GPR112_ENST00000394141.1_Silent_p.G1156G|GPR112_ENST00000412101.1_Silent_p.G1156G|GPR112_ENST00000287534.4_Silent_p.G1298G	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1361					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CCAGTCTTGGGAAAACAGCTC	0.478000													22	110					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64662882	64662882	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64662882G>A	ENST00000421419.2	-	40	5580	c.5466C>T	c.(5464-5466)tcC>tcT	p.S1822S	ATG2A_ENST00000377264.3_Silent_p.S1820S			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1820							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						GGGCTGCCGGGGACAGGATGT	0.701000													5	10					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949180	27949180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27949180G>A	ENST00000379992.2	-	6	1939	c.1490C>T	c.(1489-1491)tCc>tTc	p.S497F	LINGO2_ENST00000308675.3_Missense_Mutation_p.S497F	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	497	Ig-like C2-type.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CACAGTTAAGGAGGCTGTGAA	0.483000													20	84					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43106982	43106982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43106982G>A	ENST00000230419.4	+	9	1692	c.1471G>A	c.(1471-1473)Gag>Aag	p.E491K	PTK7_ENST00000481273.1_Missense_Mutation_p.E499K|PTK7_ENST00000345201.2_Missense_Mutation_p.E491K|PTK7_ENST00000349241.2_Intron|PTK7_ENST00000352931.2_Missense_Mutation_p.E491K	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	491	Ig-like C2-type 5.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CGGCAGCATCGAGGCGCAAGC	0.607000													20	34					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79939559	79939559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:79939559G>A	ENST00000373275.4	-	37	4399	c.4183C>T	c.(4183-4185)Cgc>Tgc	p.R1395C	BRWD3_ENST00000473691.1_Intron	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1395	Bromo 2.									breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						AATATTTGGCGAACATCCTTA	0.348000													11	42					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43771946	43771946	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43771946G>A	ENST00000244293.7	-	2	486	c.420C>T	c.(418-420)ttC>ttT	p.F140F	PSG9_ENST00000593948.1_Silent_p.F140F|PSG9_ENST00000418820.2_Silent_p.F140F|PSG9_ENST00000596730.1_Silent_p.F140F|PSG9_ENST00000443718.3_Silent_p.F140F|PSG9_ENST00000291752.5_Silent_p.F140F|PSG9_ENST00000270077.3_Silent_p.F140F			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	140	Ig-like V-type.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGTATAAGGTGAAGGTGAAAT	0.488000													77	209					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142505555	142505555	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142505555C>T	ENST00000430863.1	-	0	371					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CAGCACTGTTCATGTCCTGCA	0.532000													18	41					0	0	1	0	0
ZNF578	147660	broad.mit.edu	37	19	53015326	53015326	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53015326G>A	ENST00000421239.2	+	6	1936	c.1692G>A	c.(1690-1692)gaG>gaA	p.E564E	CTD-3099C6.5_ENST00000599143.1_RNA	NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATAGCGGAGAGAAACCTTACA	0.393000													26	68					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56320147	56320147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56320147C>T	ENST00000443188.1	-	5	2539	c.1829G>A	c.(1828-1830)aGg>aAg	p.R610K	NLRP11_ENST00000589093.1_Missense_Mutation_p.R610K|NLRP11_ENST00000592953.1_Missense_Mutation_p.R511K|NLRP11_ENST00000360133.3_Missense_Mutation_p.R610K|NLRP11_ENST00000589824.2_Missense_Mutation_p.R610K	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	610							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AGCAGTTGGCCTTATAAGTGG	0.408000													37	102					0	0	1	0	0
CA4	762	broad.mit.edu	37	17	58234891	58234891	+	Silent	SNP	G	G	A	rs145588553	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58234891G>A	ENST00000300900.4	+	4	471	c.372G>A	c.(370-372)aaG>aaA	p.K124K		NM_000717.3	NP_000708.1	P22748	CAH4_HUMAN	carbonic anhydrase IV	124					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(5)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TGCCATATAAGGGCTCGGAGC	0.612000													42	170					0	0	1	0	0
OR4F6	390648	broad.mit.edu	37	15	102346532	102346532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:102346532G>A	ENST00000328882.4	+	1	631	c.610G>A	c.(610-612)Gga>Aga	p.G204R		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TGCCAATAGTGGATTTATTTC	0.343000													45	187					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40852889	40852889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:40852889C>T	ENST00000254691.5	+	3	1654	c.1455C>T	c.(1453-1455)atC>atT	p.I485I	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	485					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TACACAAAATCTTTCTTCATC	0.443000													18	72					0	0	1	0	0
FSD1	79187	broad.mit.edu	37	19	4323544	4323544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4323544C>T	ENST00000597590.1	+	13	1375	c.1304C>T	c.(1303-1305)gCt>gTt	p.A435V	FSD1_ENST00000221856.6_Silent_p.S465S			Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	0	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGTGGCAGCTTCCAGGTGA	0.682000													12	20					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529187	57529187	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57529187G>A	ENST00000420713.1	+	4	1132	c.1020G>A	c.(1018-1020)aaG>aaA	p.K340K		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						CAACCCTTAAGAAACATAAGA	0.398000													15	39					0	0	1	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58190262	58190262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58190262G>A	ENST00000318203.5	+	5	1988	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	431					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTCCACACCAGAAGCTTCCTA	0.398000													22	99					0	0	1	0	0
PPIL3	53938	broad.mit.edu	37	2	201746149	201746149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:201746149G>A	ENST00000286175.8	-	5	630	c.247C>T	c.(247-249)Ctt>Ttt	p.L83F	PPIL3_ENST00000465823.1_5'UTR|PPIL3_ENST00000409361.1_Missense_Mutation_p.L75F|PPIL3_ENST00000392283.4_Missense_Mutation_p.L79F|PPIL3_ENST00000409449.1_Missense_Mutation_p.L83F	NM_032472.3	NP_115861.1	Q9H2H8	PPIL3_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 3	79	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity|protein binding			endometrium(1)|lung(2)	3						TTTACCTTAAGATATTCACTG	0.338000													20	37					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280433	152280433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152280433G>A	ENST00000368799.1	-	3	6964	c.6929C>T	c.(6928-6930)tCc>tTc	p.S2310F	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2310	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCACCAGAGGAATTCTCTGC	0.567000									Ichthyosis				173	496					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50048801	50048801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50048801G>A	ENST00000371564.3	-	9	2744	c.2525C>T	c.(2524-2526)aCc>aTc	p.T842I	NFATC2_ENST00000414705.1_Missense_Mutation_p.T822I|NFATC2_ENST00000396009.3_Missense_Mutation_p.T842I	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	842					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GCCAGGTCTGGTGGTGCCTGG	0.617000													10	74					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21926377	21926377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21926377C>T	ENST00000240662.2	-	2	519	c.174G>A	c.(172-174)caG>caA	p.Q58Q		NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	58						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	TGAAGATGTCCTGTAGAAAGC	0.582000											OREG0021704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	62					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134920414	134920414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134920414G>A	ENST00000398015.3	+	12	2599	c.2229G>A	c.(2227-2229)cgG>cgA	p.R743R	EPHB1_ENST00000493838.1_Silent_p.R304R	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	743	Protein kinase.		R -> Q (in a gastric adenocarcinoma sample; somatic mutation).			integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						ATGTGCATCGGGACCTGGCTG	0.547000													53	161					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795341	142795341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142795341C>T	ENST00000370498.1	-	2	1090	c.337G>A	c.(337-339)Gaa>Aaa	p.E113K		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	113										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGGTCTTCGTCCTCCTGT	0.532000													18	241					0	0	1	0	0
PBLD	64081	broad.mit.edu	37	10	70044033	70044033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70044033G>A	ENST00000358769.2	-	10	970	c.768C>T	c.(766-768)tcC>tcT	p.S256S	PBLD_ENST00000309049.4_Silent_p.S256S|PBLD_ENST00000336578.1_Silent_p.S223S	NM_022129.3	NP_071412.2	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing	256					biosynthetic process		isomerase activity			endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						CTCCTCGGTGGGAACACTGAA	0.413000													6	68					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069622	9069622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9069622G>A	ENST00000397910.4	-	3	18027	c.17824C>T	c.(17824-17826)Ctt>Ttt	p.L5942F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5944	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCGGAATAAAGAGATGAATGT	0.502000													15	48					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122756816	122756816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:122756816G>A	ENST00000227349.2	+	2	556	c.259G>A	c.(259-261)Gag>Aag	p.E87K	C11orf63_ENST00000307257.6_Missense_Mutation_p.E87K|C11orf63_ENST00000531316.1_Missense_Mutation_p.E87K	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	87										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AAGCCTGCACGAGATGGAAGA	0.537000													31	105					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39884993	39884993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39884993G>A	ENST00000260356.5	+	17	2922	c.2757G>A	c.(2755-2757)aaG>aaA	p.K919K		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	919					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CCGACCAGAAGGACTCTGACG	0.502000													7	39					0	0	1	0	0
CLDN8	9073	broad.mit.edu	37	21	31588019	31588019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31588019C>T	ENST00000399899.1	-	1	372	c.225G>A	c.(223-225)ccG>ccA	p.P75P	CLDN8_ENST00000286809.1_Silent_p.P75P	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	75					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						CCTGTAGGTCCGGAGAAAGAG	0.507000													35	72					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13098373	13098373	+	Splice_Site	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:13098373G>T	ENST00000399002.2	+	8	1426		c.e8+1		SPTLC3_ENST00000378194.4_Intron	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3						sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	TGGAAGGAAGGTAAGAGAGGG	0.483000													13	71					9.31168e-06	9.3299e-06	1	1	0
CACNA2D4	93589	broad.mit.edu	37	12	2022194	2022194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2022194C>T	ENST00000382722.5	-	3	783	c.421G>A	c.(421-423)Gtc>Atc	p.V141I	CACNA2D4_ENST00000585708.1_Missense_Mutation_p.V77I|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.V141I|CACNA2D4_ENST00000586184.1_Missense_Mutation_p.V141I|CACNA2D4_ENST00000585732.1_Missense_Mutation_p.V141I|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.V77I	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	141						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity	p.V141I(2)		endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AGTACCTGGACCGCCTCGACT	0.602000													4	19					0	0	1	0	0
WRB	7485	broad.mit.edu	37	21	40765134	40765134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:40765134C>T	ENST00000333781.5	+	4	520	c.379C>T	c.(379-381)Cct>Tct	p.P127S	WRB_ENST00000380708.1_Missense_Mutation_p.P93S|WRB_ENST00000466787.1_3'UTR|WRB_ENST00000541890.1_Missense_Mutation_p.P127S|WRB_ENST00000398753.1_Missense_Mutation_p.P93S	NM_004627.4	NP_004618.2	O00258	WRB_HUMAN	tryptophan rich basic protein	127						integral to membrane|nucleolus				endometrium(3)	3		Prostate(19;1.2e-06)				TTATTCTGTCCCTGTGGCTGT	0.498000													22	64					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116046221	116046221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116046221C>T	ENST00000603594.1	+	11	1842	c.1521C>T	c.(1519-1521)ttC>ttT	p.F507F	VWA2_ENST00000392982.3_Silent_p.F507F	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	507	VWFA 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		AGGATCTGTTCAACCAAATCC	0.627000													13	49					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54946752	54946752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54946752G>A	ENST00000301194.4	+	11	1278	c.1156G>A	c.(1156-1158)Gaa>Aaa	p.E386K	TTYH1_ENST00000376530.3_Missense_Mutation_p.E386K|TTYH1_ENST00000376531.3_Missense_Mutation_p.E386K|TTYH1_ENST00000489425.1_3'UTR|TTYH1_ENST00000391739.3_Missense_Mutation_p.416_416insQ			Q9H313	TTYH1_HUMAN	tweety family member 1	386					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GGGCCTGTGCGAAGACGCCCT	0.677000													18	46					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21690081	21690081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21690081G>A	ENST00000261195.2	-	16	2173	c.1919C>T	c.(1918-1920)tCc>tTc	p.S640F		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	640					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TGGTACTGAGGAAGGCCTGGG	0.443000													15	41					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316938	30316938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30316938C>T	ENST00000375377.1	-	3	2240	c.2139G>A	c.(2137-2139)ccG>ccA	p.P713P		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	713										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CTGCACGACTCGGCCCTCCCA	0.572000													19	45					0	0	1	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206725	142206725	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142206725G>A	ENST00000426318.2	-	0	180																											CTCCAAGTCTGGTGACACATC	0.483000													50	94					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169812155	169812155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169812155G>A	ENST00000335742.7	+	12	2930	c.1573G>A	c.(1573-1575)Gac>Aac	p.D525N	PALLD_ENST00000261509.6_Missense_Mutation_p.D683N|PALLD_ENST00000507735.1_Missense_Mutation_p.D196N|PALLD_ENST00000512127.1_Missense_Mutation_p.D301N|CBR4_ENST00000509108.1_Intron|PALLD_ENST00000505667.1_Missense_Mutation_p.D683N			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	907	Ig-like C2-type 2.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TGTTATTCAAGACCTGGAACG	0.463000									Pancreatic Cancer, Familial Clustering of				27	58					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82321756	82321756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:82321756C>T	ENST00000376520.4	+	11	1706	c.878C>T	c.(877-879)cCa>cTa	p.P293L	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376537.4_Missense_Mutation_p.P293L|TLE4_ENST00000265284.6_Missense_Mutation_p.P268L|TLE4_ENST00000376544.3_Intron|TLE4_ENST00000376552.2_Missense_Mutation_p.P293L			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CCGATTAGTCCAGCCTCTATT	0.527000													65	158					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20442548	20442548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20442548G>A	ENST00000331849.4	+	10	1360	c.1213G>A	c.(1213-1215)Gat>Aat	p.D405N		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	405					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CCAGATTGTGGATGATGAGGG	0.552000													11	102					0	0	1	0	0
HTR3E	285242	broad.mit.edu	37	3	183823084	183823084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183823084G>A	ENST00000415389.2	+	6	1055	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	HTR3E_ENST00000440596.2_Missense_Mutation_p.E223K|HTR3E_ENST00000425359.2_Missense_Mutation_p.E182K|HTR3E_ENST00000436361.2_Missense_Mutation_p.E197K|HTR3E_ENST00000335304.2_Missense_Mutation_p.E212K	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	197						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CATGGAGAAAGAAGTGTGGGA	0.498000													16	46					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179633587	179633587	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179633587C>T	ENST00000589042.1	-	38	9200	c.8976G>A	c.(8974-8976)gtG>gtA	p.V2992V	TTN_ENST00000342992.6_Silent_p.V2992V|TTN_ENST00000360870.5_Silent_p.V2992V|TTN_ENST00000591111.1_Silent_p.V2992V|TTN_ENST00000342175.6_Silent_p.V2946V|TTN_ENST00000359218.5_Silent_p.V2946V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V2946V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2730	Ig-like 17.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCATAGTTCACTGTCACCT	0.388000													14	54					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8758078	8758078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8758078C>T	ENST00000229335.6	-	3	263	c.160G>A	c.(160-162)Ggc>Agc	p.G54S	AICDA_ENST00000537228.1_Missense_Mutation_p.G54S	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	54					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					ACGTGGCAGCCGTTCTGGAGA	0.557000													15	47					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113950885	113950885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113950885G>A	ENST00000245796.6	+	8	2165	c.1970G>A	c.(1969-1971)cGa>cAa	p.R657Q	PSD4_ENST00000441564.2_Missense_Mutation_p.R629Q	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	657	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GAACGGGAGCGAATCCTCTAC	0.607000													27	68					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602980	138602980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138602980C>T	ENST00000440172.1	-	2	1440	c.1392G>A	c.(1390-1392)atG>atA	p.M464I	KIAA1549_ENST00000422774.1_Missense_Mutation_p.M464I|KIAA1549_ENST00000242365.4_Missense_Mutation_p.M414I	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	464						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CGACGCTACTCATTAGAGAGA	0.493000			O	BRAF	pilocytic astrocytoma								18	51					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2132987	2132987	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:2132987G>A	ENST00000511885.2	-	17	2115	c.1762C>T	c.(1762-1764)Cag>Tag	p.Q588*	POLN_ENST00000382865.1_Nonsense_Mutation_p.Q588*			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	588					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			GTAGTAATCTGAATTGGGTGC	0.343000								DNA polymerases (catalytic subunits)					8	95					0	0	1	0	0
SLC16A3	9123	broad.mit.edu	37	17	80193902	80193902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80193902G>A	ENST00000581287.1	+	1	2340	c.18G>A	c.(16-18)gtG>gtA	p.V6V	SLC16A3_ENST00000392341.1_Silent_p.V6V|SLC16A3_ENST00000582743.1_Silent_p.V6V|SLC16A3_ENST00000392339.1_Silent_p.V6V|SLC16A3_ENST00000584781.1_3'UTR	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	6					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	GGGCCGTGGTGGACGAGGGCC	0.672000													12	21					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154284938	154284938	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154284938G>A	ENST00000285873.7	-	17	2569	c.2494C>T	c.(2494-2496)Cca>Tca	p.P832S		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	832					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTCTCTTTTGGTGGCTCCTTT	0.338000													24	85					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82444475	82444475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:82444475G>A	ENST00000268206.7	-	18	2488	c.2320C>T	c.(2320-2322)Cgt>Tgt	p.R774C	EFTUD1_ENST00000359445.3_Missense_Mutation_p.R723C	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	774					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						TCCATAGAACGAATCAAATCA	0.418000													25	91					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175742	159175742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159175742G>A	ENST00000537147.1	+	3	1356	c.513G>A	c.(511-513)gtG>gtA	p.V171V	DARC_ENST00000368122.2_Silent_p.V171V|DARC_ENST00000368121.2_Silent_p.V173V			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	171					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					GGCTCACTGTGGGAATTTGGG	0.632000													5	24					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48597980	48597980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48597980G>A	ENST00000537810.1	-	14	1677	c.1073C>T	c.(1072-1074)tCt>tTt	p.S358F	FRYL_ENST00000506685.1_Missense_Mutation_p.S64F|FRYL_ENST00000503238.1_Missense_Mutation_p.S358F|FRYL_ENST00000358350.4_Missense_Mutation_p.S358F|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507711.1_Missense_Mutation_p.S358F			O94915	FRYL_HUMAN	FRY-like	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.S358C(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						TCTATACAAAGATTCCAGTGC	0.284000													8	31					0	0	1	0	0
PAPL	390928	broad.mit.edu	37	19	39576015	39576015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39576015C>T	ENST00000331256.5	+	2	380	c.106C>T	c.(106-108)Cat>Tat	p.H36Y	PAPL_ENST00000594229.1_Missense_Mutation_p.H36Y	NM_001004318.2	NP_001004318.2	Q6ZNF0	PAPL_HUMAN		36						extracellular region	acid phosphatase activity|metal ion binding										AGAGCAAGTCCATCTGTCTTA	0.582000													36	116					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127611766	127611766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127611766C>T	ENST00000508053.1	-	65	8532	c.7558G>A	c.(7558-7560)Ggg>Agg	p.G2520R	FBN2_ENST00000262464.4_Missense_Mutation_p.G2520R			P35556	FBN2_HUMAN	fibrillin 2	2520	EGF-like 42; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGGACATACCCCCTCGGACAT	0.433000													31	148					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54364942	54364942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:54364942G>A	ENST00000306888.2	-	4	807	c.556C>T	c.(556-558)Ccc>Tcc	p.P186S	LNX1-AS1_ENST00000502373.1_RNA|LNX1_ENST00000263925.7_Missense_Mutation_p.P282S|FIP1L1_ENST00000507166.1_Intron	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	282						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			CTTTCACTGGGATCTACTCGA	0.443000													26	55					0	0	1	0	0
ALAD	210	broad.mit.edu	37	9	116155791	116155791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116155791G>A	ENST00000409155.3	-	2	245	c.49C>T	c.(49-51)Cgg>Tgg	p.R17W	ALAD_ENST00000277315.5_Missense_Mutation_p.R17W	NM_000031.5	NP_000022.3	P13716	HEM2_HUMAN	aminolevulinate dehydratase	17					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|stomach(1)	9					Aminolevulinic acid(DB00855)	TGCCAGGCCCGAAGTAGTGGG	0.617000													13	46					0	0	1	0	0
OR7C1	26664	broad.mit.edu	37	19	14910370	14910370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14910370G>A	ENST00000248073.2	-	1	653	c.579C>T	c.(577-579)ttC>ttT	p.F193F	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	193					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						CGTTATTAATGAAGGTGTCAG	0.398000													14	148					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765360	18765360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18765360G>A	ENST00000304081.4	-	5	985	c.885C>T	c.(883-885)ttC>ttT	p.F295F	NT5C1B_ENST00000359846.2_Silent_p.F355F|NT5C1B-RDH14_ENST00000532967.1_Silent_p.F355F|NT5C1B_ENST00000600945.1_Silent_p.F355F	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				ATACCTTGACGAAGCGGAACG	0.572000													31	119					0	0	1	0	0
KCNIP2	30819	broad.mit.edu	37	10	103603287	103603287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103603287G>A	ENST00000358038.3	-	1	390	c.39C>T	c.(37-39)tcC>tcT	p.S13S	KCNIP2_ENST00000370046.1_Silent_p.S13S|KCNIP2_ENST00000461105.1_Silent_p.S13S|KCNIP2_ENST00000355657.2_5'UTR|KCNIP2_ENST00000356640.2_Silent_p.S13S|KCNIP2_ENST00000353068.3_Silent_p.S13S|KCNIP2_ENST00000343195.4_Silent_p.S13S	NM_173192.2|NM_173193.2|NM_173195.2	NP_775284.1|NP_775285.1|NP_775287.1	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2	13					clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		CCAGGTCTCGGGAATCGGACA	0.726000													5	12					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8670542	8670542	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8670542G>A	ENST00000270328.4	-	2	320	c.54C>T	c.(52-54)ctC>ctT	p.L18L	ADAMTS10_ENST00000596709.1_Intron|ADAMTS10_ENST00000597188.1_Silent_p.L18L			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	18					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CCTCGAACATGAGGCCCAGCC	0.657000													10	18					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139193282	139193282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139193282G>A	ENST00000274710.3	+	3	965	c.760G>A	c.(760-762)Ggc>Agc	p.G254S		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	254					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCCCTCAGGGCCCAGGGGG	0.622000													9	20					0	0	1	0	0
NR1H2	7376	broad.mit.edu	37	19	50881015	50881015	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50881015C>T	ENST00000253727.5	+	4	304	c.69C>T	c.(67-69)gcC>gcT	p.A23A	NR1H2_ENST00000411902.2_Silent_p.A23A|NR1H2_ENST00000598168.1_Silent_p.A23A|NR1H2_ENST00000593926.1_Silent_p.A23A|NR1H2_ENST00000599105.1_Silent_p.A23A|NR1H2_ENST00000542413.1_5'UTR	NM_007121.5	NP_009052.3	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	23					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AGCCTGGCGCCCCTTCTTCTT	0.632000													24	58					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50764888	50764888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50764888C>T	ENST00000440075.2	+	21	2628	c.2581C>T	c.(2581-2583)Cgc>Tgc	p.R861C	MYH14_ENST00000425460.1_Missense_Mutation_p.R828C|MYH14_ENST00000262269.8_Missense_Mutation_p.R861C|MYH14_ENST00000376970.2_Missense_Mutation_p.R853C|MYH14_ENST00000598205.1_Missense_Mutation_p.R828C|MYH14_ENST00000596571.1_Missense_Mutation_p.R820C|MYH14_ENST00000601313.1_Missense_Mutation_p.R861C			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	820					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		ATACCTGGCTCGCAGGTGGGC	0.662000													13	13					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17228372	17228372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:17228372C>T	ENST00000261381.6	-	9	2069	c.1985G>A	c.(1984-1986)cGg>cAg	p.R662Q	CTD-2576D5.4_ENST00000567344.1_RNA	NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	662					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CGTCTCGGCCCGTCGAAGACC	0.612000													7	89					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141359	143141359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143141359C>T	ENST00000332690.1	+	1	814	c.814C>T	c.(814-816)Cca>Tca	p.P272S	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	272					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					AGGTATTTTTCCACCTCTGGA	0.488000													67	137					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118375399	118375399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118375399C>T	ENST00000534358.1	+	27	8815	c.8792C>T	c.(8791-8793)cCa>cTa	p.P2931L	KMT2A_ENST00000354520.4_Missense_Mutation_p.P2890L|KMT2A_ENST00000389506.5_Missense_Mutation_p.P2928L	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CTAGAGCTACCATCTGATCTG	0.498000													49	129					0	0	1	0	0
RFC3	5983	broad.mit.edu	37	13	34409298	34409298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:34409298C>T	ENST00000380071.3	+	8	953	c.823C>T	c.(823-825)Cgt>Tgt	p.R275C	RFC3_ENST00000434425.1_Missense_Mutation_p.R275C	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	275					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		CCTTGAAGTTCGTGGAAGGCT	0.313000													13	76					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451045	138451045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138451045G>A	ENST00000344876.4	-	1	2584	c.2198C>T	c.(2197-2199)tCc>tTc	p.S733F	PCDH18_ENST00000507846.1_Missense_Mutation_p.S513F|PCDH18_ENST00000412923.2_Missense_Mutation_p.S733F|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	733					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					GCAGTTATAGGATCTAGTGTC	0.438000													18	59					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140777335	140777335	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140777335G>A	ENST00000371372.1	+	3	675	c.530_splice	c.e3+1	p.G177_splice	CACNA1B_ENST00000371357.1_Splice_Site_p.G177_splice|CACNA1B_ENST00000371363.1_Splice_Site_p.G177_splice|RP11-188C12.3_ENST00000371390.1_RNA|CACNA1B_ENST00000277551.2_Splice_Site_p.G177_splice|CACNA1B_ENST00000371355.4_Splice_Site_p.G177_splice|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	177					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GTCCTCACAGGGTAGGCAAGC	0.622000													37	221					0	0	1	0	0
DDX24	57062	broad.mit.edu	37	14	94527347	94527347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94527347G>A	ENST00000330836.5	-	4	1440	c.1309C>T	c.(1309-1311)Cgt>Tgt	p.R437C	DDX24_ENST00000555054.1_Missense_Mutation_p.R394C|DDX24_ENST00000544005.1_Missense_Mutation_p.R187C	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	437	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		ATCTCAGGACGACGGTTCAGC	0.443000													50	117					0	0	1	0	0
VRK3	51231	broad.mit.edu	37	19	50504104	50504104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50504104G>A	ENST00000443401.2	-	5	492	c.14C>T	c.(13-15)cCa>cTa	p.P5L	VRK3_ENST00000377011.2_Silent_p.P135P|VRK3_ENST00000593919.1_Silent_p.P185P|VRK3_ENST00000601341.1_Silent_p.P135P|VRK3_ENST00000601912.1_Silent_p.P135P|VRK3_ENST00000599538.1_Silent_p.P185P|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000316763.3_Silent_p.P185P|VRK3_ENST00000594092.1_Silent_p.P185P|VRK3_ENST00000594948.1_Silent_p.P185P			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	0						nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GGGTGGAGGTGGGTGCAGCTG	0.572000													6	26					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67129918	67129918	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67129918G>A	ENST00000284425.2	-	6	829	c.655C>T	c.(655-657)Cac>Tac	p.H219Y		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	219					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATCTCATTGTGAAGAAGATTT	0.313000													10	67					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97547984	97547984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:97547984C>T	ENST00000370192.3	-	22	2909	c.2809G>A	c.(2809-2811)Gaa>Aaa	p.E937K		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	937					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TTGCTCAATTCACCAAATGTT	0.363000													34	144					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6896430	6896430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6896430C>T	ENST00000312053.4	+	3	153	c.116C>T	c.(115-117)aCc>aTc	p.T39I	EMR1_ENST00000381407.5_Missense_Mutation_p.T39I|EMR1_ENST00000601198.1_3'UTR|EMR1_ENST00000381404.4_Missense_Mutation_p.T39I|EMR1_ENST00000250572.8_Missense_Mutation_p.T39I|EMR1_ENST00000450315.3_Missense_Mutation_p.T39I	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	39	EGF-like 1.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					AGAGACAGTACCTTGTGCCCA	0.453000													31	171					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19372292	19372292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19372292C>T	ENST00000291481.7	-	2	147	c.84G>A	c.(82-84)ggG>ggA	p.G28G	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	28					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			CACGCTGCGCCCCCGCAGGGG	0.726000													8	51					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49446098	49446098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49446098G>A	ENST00000374201.3	-	8	1159	c.857C>T	c.(856-858)tCg>tTg	p.S286L	FRMPD2_ENST00000407470.4_Missense_Mutation_p.S255L|FRMPD2_ENST00000305531.3_Missense_Mutation_p.S262L	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	286					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GTCTGCTGCCGAGTGCACAGA	0.572000													39	77					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22362829	22362829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22362829C>T	ENST00000397121.2	-	3	2007	c.1690G>A	c.(1690-1692)Gaa>Aaa	p.E564K		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CCACATTCTTCACATTTGTAG	0.378000													34	90					0	0	1	0	0
IL36G	56300	broad.mit.edu	37	2	113736846	113736846	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113736846G>A	ENST00000259205.4	+	3	173	c.104G>A	c.(103-105)tGg>tAg	p.W35*	IL36G_ENST00000376489.2_Intron	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	35					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						CAGCAAGTGTGGACCCTTCAG	0.448000													12	59					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907474	12907474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12907474C>T	ENST00000317869.6	-	2	894	c.669G>A	c.(667-669)gaG>gaA	p.E223E		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TACTGCTCTGCTCCTCTTCTG	0.463000													62	180					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57868278	57868278	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57868278C>T	ENST00000391705.3	+	4	1325	c.1041C>T	c.(1039-1041)agC>agT	p.S347S	ZNF304_ENST00000598744.1_Silent_p.S305S|ZNF304_ENST00000443917.2_Silent_p.S394S|ZNF304_ENST00000282286.5_Silent_p.S347S	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		ACAGCAGAAGCTCCCACCTTG	0.473000													31	78					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178139858	178139858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178139858G>A	ENST00000335815.2	-	5	1218	c.1021C>T	c.(1021-1023)Ctt>Ttt	p.L341F		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	341					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		CATCCAGAAAGGGATGTGCTG	0.403000													47	89					0	0	1	0	0
MPL	4352	broad.mit.edu	37	1	43803534	43803534	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43803534C>T	ENST00000372470.3	+	1	57	c.15C>T	c.(13-15)gcC>gcT	p.A5A	MPL_ENST00000413998.2_Silent_p.A5A	NM_005373.2	NP_005364.1	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	5					cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(551)|large_intestine(3)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	567	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTCCTGGGCCCTCTTCATGG	0.632000			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						7	18					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22047044	22047044	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:22047044A>T	ENST00000261200.4	-	12	1723	c.1724T>A	c.(1723-1725)cTg>cAg	p.L575Q	ABCC9_ENST00000261201.4_Missense_Mutation_p.L575Q|ABCC9_ENST00000345162.2_Missense_Mutation_p.L575Q	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	575	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAAGAGAGACAGTGAAGCAAA	0.478000													13	97					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985509	108985509	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108985509C>T	ENST00000392806.3	-	2	819	c.651G>A	c.(649-651)caG>caA	p.Q217Q		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	217						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						CCTGGACTTCCTGGTCCCCCT	0.697000													12	79					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17448979	17448979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17448979C>T	ENST00000324894.8	+	2	284	c.216C>T	c.(214-216)ccC>ccT	p.P72P	GTPBP3_ENST00000361619.5_Silent_p.P94P|GTPBP3_ENST00000598038.1_3'UTR|GTPBP3_ENST00000600625.1_Silent_p.P72P|GTPBP3_ENST00000358792.7_Silent_p.P72P	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	72					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						GAGACCTGCCCCTTGCTCGCC	0.711000													4	16					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69718372	69718372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69718372G>A	ENST00000194900.4	+	16	2259	c.1918G>A	c.(1918-1920)Gga>Aga	p.G640R	DLG3_ENST00000542398.1_Missense_Mutation_p.G157R|DLG3_ENST00000374360.3_Missense_Mutation_p.G608R|DLG3_ENST00000374355.3_Missense_Mutation_p.G303R|DLG3_ENST00000461646.1_3'UTR			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	608	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					TGTTGCAGAAGGACAAGAGGA	0.517000													8	13					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767944	57767944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57767944G>A	ENST00000371030.2	+	1	1870	c.1870G>A	c.(1870-1872)Ggg>Agg	p.G624R		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	624						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCAGGTGTACGGGGATGAGAC	0.607000													33	79					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255871	140255871	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140255871G>A	ENST00000398631.2	+	1	814	c.814G>A	c.(814-816)Gga>Aga	p.G272R	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAGACGAAGGACTTAATGG	0.383000													39	130					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143633133	143633133	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143633133C>T	ENST00000408955.2	+	1	875	c.808C>T	c.(808-810)Caa>Taa	p.Q270*		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CTCAGTCCTTCAAGAGAAGCT	0.507000													41	96					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122001064	122001064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122001064G>A	ENST00000498619.1	+	6	2181	c.1743G>A	c.(1741-1743)ggG>ggA	p.G581G	CASR_ENST00000296154.5_Silent_p.G571G|CASR_ENST00000490131.1_Silent_p.G571G	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	571					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GTCCTGATGGGGAGTATAGTG	0.597000													31	67					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209783237	209783237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209783237G>A	ENST00000009105.1	+	9	1035	c.790G>A	c.(790-792)Gag>Aag	p.E264K	CAMK1G_ENST00000494990.1_3'UTR|CAMK1G_ENST00000361322.2_Missense_Mutation_p.E264K			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	264	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		GGATCCGAACGAGCGGTACAC	0.498000													21	76					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29430158	29430158	+	Silent	SNP	C	C	T	rs144363872	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29430158C>T	ENST00000377136.1	+	4	1077	c.612C>T	c.(610-612)ttC>ttT	p.F204F	OR2H1_ENST00000377133.1_Silent_p.F204F|OR2H1_ENST00000442615.1_Silent_p.F204F|OR2H1_ENST00000396792.2_Silent_p.F204F|OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377132.1_Silent_p.F204F			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						GTGTCATCTTCGTGGTTGTGC	0.502000													67	168					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33628011	33628011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33628011C>T	ENST00000380099.3	+	2	935	c.927C>T	c.(925-927)acC>acT	p.T309T	KL_ENST00000426690.2_Silent_p.T2T|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	309	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GAAGAATGACCGACCACAGCA	0.463000													56	183					0	0	1	0	0
RP11-337C18.8	0	broad.mit.edu	37	1	146649854	146649854	+	RNA	SNP	C	C	T	rs1053423		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:146649854C>T	ENST00000607149.1	+	0	350																											AGTTCTTCGCCCCCTGGTGTG	0.567000													10	111					0	0	1	0	0
IFNA2	3440	broad.mit.edu	37	9	21384900	21384900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21384900C>T	ENST00000380206.2	-	1	496	c.429G>A	c.(427-429)agG>agA	p.R143R		NM_000605.3	NP_000596.2	P01563	IFNA2_HUMAN	interferon, alpha 2	143					blood coagulation|cell-cell signaling|induction of apoptosis|inflammatory response|negative regulation of interleukin-13 secretion|negative regulation of interleukin-5 secretion|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of transcription, DNA-dependent|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(2)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	13				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)	Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GGAAGTATTTCCTCACAGCCA	0.478000													103	213					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130060506	130060506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130060506C>T	ENST00000278742.5	+	7	1210	c.792C>T	c.(790-792)gaC>gaT	p.D264D		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	264	CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GCAGCTTTGACCTTGCGTCCT	0.701000													9	21					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23895187	23895187	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23895187C>T	ENST00000355349.3	-	19	2310	c.2148G>A	c.(2146-2148)ggG>ggA	p.G716G		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	716	Myosin head-like.		G -> R (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCCGGAAGTCCCCGTAGAGGA	0.607000													14	51					0	0	1	0	0
CLEC4G	339390	broad.mit.edu	37	19	7794920	7794920	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7794920C>T	ENST00000328853.5	-	7	680	c.612G>A	c.(610-612)ggG>ggA	p.G204G		NM_001244856.1|NM_198492.3	NP_001231785.1|NP_940894.1	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	204	C-type lectin.					integral to membrane	protein binding|sugar binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(1)|lung(1)	6						CATCCAGGCCCCCAACGATCA	0.677000													6	10					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96267073	96267073	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96267073C>T	ENST00000225235.4	+	7	1679	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F		NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	523	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				GGAAAAGTTTCAGTGAAACAA	0.338000													16	85					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6919588	6919588	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6919588G>T	ENST00000312053.4	+	13	1487	c.1450G>T	c.(1450-1452)Gtg>Ttg	p.V484L	EMR1_ENST00000381407.5_Missense_Mutation_p.V343L|EMR1_ENST00000381404.4_Missense_Mutation_p.V432L|EMR1_ENST00000250572.8_Missense_Mutation_p.V484L|EMR1_ENST00000450315.3_Missense_Mutation_p.V307L	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	484	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TGTCTCCTTTGTGGGCATGGA	0.453000													55	101					7.41606e-26	7.4644e-26	1	1	0
AVEN	57099	broad.mit.edu	37	15	34160047	34160047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34160047G>A	ENST00000306730.3	-	5	751	c.622C>T	c.(622-624)Cct>Tct	p.P208S	AVEN_ENST00000558136.1_5'UTR	NM_020371.2	NP_065104.1	Q9NQS1	AVEN_HUMAN	apoptosis, caspase activation inhibitor	208					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	7		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		ACCTCTAAAGGAACTGTACCC	0.448000													21	71					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56436015	56436015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56436015G>A	ENST00000584437.1	-	8	3077	c.1122C>T	c.(1120-1122)ccC>ccT	p.P374P	RNF43_ENST00000407977.2_Silent_p.P374P|RNF43_ENST00000577716.1_Silent_p.P374P|RNF43_ENST00000583753.1_Silent_p.P333P|RNF43_ENST00000581868.1_Silent_p.P247P|RNF43_ENST00000577625.1_Silent_p.P247P|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000500597.2_Silent_p.P333P			Q68DV7	RNF43_HUMAN	ring finger protein 43	374						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATGGCAGGAAGGGACCAGGTC	0.687000													4	3					0	0	1	0	0
KCNN1	3780	broad.mit.edu	37	19	18092675	18092675	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18092675C>T	ENST00000601725.1	+	0	291																											ACGTACGCGCCCTCGGTGGCC	0.652000													9	25					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241812439	241812439	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241812439G>A	ENST00000307503.3	+	5	955	c.568G>A	c.(568-570)Ggg>Agg	p.G190R		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	190			G -> R (in HP1).		glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity	p.G190R(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ATCCCTGGGCGGGACCCCCCT	0.662000													14	120					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42695102	42695102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:42695102C>T	ENST00000230882.4	+	5	540	c.350C>T	c.(349-351)tCg>tTg	p.S117L	GHR_ENST00000357703.3_Missense_Mutation_p.S95L|GHR_ENST00000537449.1_5'UTR	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	117					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTTAATTCATCGTTTACCTCC	0.378000													15	38					0	0	1	0	0
SLC5A5	6528	broad.mit.edu	37	19	17986820	17986820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17986820C>T	ENST00000222248.3	+	5	950	c.603C>T	c.(601-603)ggC>ggT	p.G201G		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	201					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						TGCTAAGTGGCTTCTGGGTTG	0.622000													18	76					0	0	1	0	0
MS4A6A	64231	broad.mit.edu	37	11	59949119	59949119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59949119C>T	ENST00000528851.1	-	2	222	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	MS4A6A_ENST00000323961.3_Missense_Mutation_p.E28K|MS4A6A_ENST00000412309.2_Missense_Mutation_p.E56K|MS4A6A_ENST00000420732.2_Missense_Mutation_p.E28K|MS4A6A_ENST00000426738.2_Missense_Mutation_p.E28K|MS4A6A_ENST00000529054.1_Missense_Mutation_p.E56K|MS4A6A_ENST00000530839.1_Missense_Mutation_p.E28K|MS4A6A_ENST00000533023.1_Missense_Mutation_p.E28K|MS4A6A_ENST00000532169.1_Missense_Mutation_p.E28K			Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member 6A	28						integral to membrane	receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGGTGGGTTCGGGTTTCTCT	0.463000													57	127					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038256	75038256	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75038256C>T	ENST00000326665.5	-	14	3356	c.3138G>A	c.(3136-3138)agG>agA	p.R1046R	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1046	Glu-rich.							p.R1046S(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AAATTTCTTTCCTATCATCTT	0.453000													56	224					0	0	1	0	0
IL7	3574	broad.mit.edu	37	8	79710412	79710412	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:79710412G>A	ENST00000263851.4	-	2	642	c.42C>T	c.(40-42)ccC>ccT	p.P14P	IL7_ENST00000379113.2_Silent_p.P14P|IL7_ENST00000520269.1_Silent_p.P14P	NM_000880.3|NM_001199886.1|NM_001199887.1	NP_000871.1|NP_001186815.1|NP_001186816.1	P13232	IL7_HUMAN	interleukin 7	14					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding			endometrium(2)|large_intestine(2)|lung(1)	5						CAAGGATCAGGGGAGGAAGTC	0.353000													13	51					0	0	1	0	0
FADS6	283985	broad.mit.edu	37	17	72878706	72878706	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72878706G>A	ENST00000310226.6	-	3	506	c.492C>T	c.(490-492)ttC>ttT	p.F164F		NM_178128.3	NP_835229.2	Q8N9I5	FADS6_HUMAN	fatty acid desaturase 6	170					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity			endometrium(3)|kidney(1)|lung(4)	8	all_lung(278;0.172)|Lung NSC(278;0.207)					AAGGAGCAAGGAACATGTAGA	0.612000													6	16					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122532572	122532572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:122532572G>A	ENST00000264357.5	+	7	1290	c.998G>A	c.(997-999)cGg>cAg	p.R333Q	GRIA3_ENST00000542149.1_Missense_Mutation_p.R333Q|GRIA3_ENST00000371256.5_Missense_Mutation_p.R333Q|GRIA3_ENST00000371251.1_Missense_Mutation_p.R333Q|GRIA3_ENST00000541091.1_Missense_Mutation_p.R317Q	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	333					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity	p.R333Q(3)		breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	GATGTGTCCCGGAGAGGAAGT	0.483000													19	11					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324066	152324066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152324066G>A	ENST00000388718.5	-	3	6268	c.6196C>T	c.(6196-6198)Cat>Tat	p.H2066Y	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2066							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTCTCATGAACTGAGGAT	0.532000													196	481					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45127468	45127468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45127468C>T	ENST00000296129.1	-	9	2307	c.2173G>A	c.(2173-2175)Ggg>Agg	p.G725R		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	725						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCCTTTCGCCCTTTCTGAAAC	0.488000													26	290					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53069372	53069372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53069372C>T	ENST00000252244.3	-	9	1598	c.1540G>A	c.(1540-1542)Gga>Aga	p.G514R		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	514	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						ctgccacctccacTGATGGTG	0.607000													17	42					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68934353	68934353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68934353G>A	ENST00000288368.4	+	4	696	c.419G>A	c.(418-420)aGa>aAa	p.R140K	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	140	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AACAAAATAAGAACAATCCGG	0.328000													5	52					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13363279	13363279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13363279G>A	ENST00000254508.5	-	36	5054	c.4972C>T	c.(4972-4974)Ctg>Ttg	p.L1658L		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1658					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TTCATGCTCAGGTGCTTCCGC	0.592000													41	298					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71853601	71853601	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71853601G>A	ENST00000373255.4	+	5	852	c.588_splice	c.e5+1	p.K196_splice		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	196	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						TGGGACAGAAGGTAACAAAGA	0.418000													11	33					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128498536	128498536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128498536G>A	ENST00000325888.8	+	48	8398	c.8137G>A	c.(8137-8139)Gaa>Aaa	p.E2713K	FLNC_ENST00000346177.6_Missense_Mutation_p.E2680K|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2713	Interaction with INPPL1.|Self-association site, tail (By similarity).				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GTGGGGTGACGAAAGTGTCCC	0.542000													20	33					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15789234	15789234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15789234C>T	ENST00000359621.4	+	4	259	c.234C>T	c.(232-234)tcC>tcT	p.S78S		NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	78	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						CCAGCTCCTCCAGGACCTACC	0.617000													39	100					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070255	9070255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9070255C>T	ENST00000397910.4	-	3	17394	c.17191G>A	c.(17191-17193)Gaa>Aaa	p.E5731K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5733	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATTGTGATTCATGTCCAGAA	0.488000													25	72					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87173491	87173491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87173491C>T	ENST00000265724.3	-	18	2582	c.2165G>A	c.(2164-2166)gGa>gAa	p.G722E	ABCB1_ENST00000543898.1_Missense_Mutation_p.G658E	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	722	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity	p.G722V(1)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTGCAGGCCTCCATTTATAAT	0.358000													29	55					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228562353	228562353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228562353G>A	ENST00000570156.2	+	108	25508	c.25434G>A	c.(25432-25434)ctG>ctA	p.L8478L	OBSCN_ENST00000366707.4_Silent_p.L5155L|OBSCN_ENST00000422127.1_Silent_p.L7521L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7521					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCAGCTTCTGACCATCCTGG	0.622000													25	65					0	0	1	0	0
KCTD9	54793	broad.mit.edu	37	8	25298174	25298174	+	Missense_Mutation	SNP	G	G	A	rs143658803	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:25298174G>A	ENST00000221200.4	-	4	450	c.230C>T	c.(229-231)tCt>tTt	p.S77F	KCTD9_ENST00000518067.1_5'UTR	NM_017634.3	NP_060104.2	Q7L273	KCTD9_HUMAN	potassium channel tetramerization domain containing 9	77	KHA.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(2)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)	12		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)		AGGAGGCTTAGAATCTGTCTG	0.393000													28	53					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35700224	35700224	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35700224G>A	ENST00000314888.9	-	49	6977	c.6624C>T	c.(6622-6624)agC>agT	p.S2208S	TLN1_ENST00000540444.1_Silent_p.S2096S	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	2208					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TAGCACGGCGGCTCAGATTGG	0.537000													9	79					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247712462	247712462	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247712462C>T	ENST00000366490.3	+	4	489	c.331C>T	c.(331-333)Cag>Tag	p.Q111*	GCSAML_ENST00000366491.2_5'UTR|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366488.4_5'UTR|GCSAML_ENST00000366489.1_5'UTR|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000536561.1_5'UTR					germinal center-associated, signaling and motility-like																		GAGTGAAACTCAGGAGCTGAG	0.502000													6	60					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61564393	61564393	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61564393G>A	ENST00000457692.1	+	5	690	c.357G>A	c.(355-357)ggG>ggA	p.G119G	SERPINB2_ENST00000482254.1_3'UTR|SERPINB2_ENST00000299502.4_Silent_p.G119G	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	119					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CATCCACAGGGAATTATTTAC	0.408000													37	79					0	0	1	0	0
ZNF652	22834	broad.mit.edu	37	17	47390089	47390089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47390089G>A	ENST00000362063.2	-	3	1337	c.1019C>T	c.(1018-1020)aCc>aTc	p.T340I	ZNF652_ENST00000430262.2_Missense_Mutation_p.T340I	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			ATGAGCCATGGTATAGAATTT	0.378000													16	54					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15646221	15646221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15646221C>T	ENST00000378076.3	-	20	2457	c.2104G>A	c.(2104-2106)Gaa>Aaa	p.E702K	ITGA8_ENST00000477064.1_5'UTR	NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	702					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TTGTTGCGTTCGATTCCAACA	0.383000													36	77					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	80993272	80993272	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:80993272G>A	ENST00000555265.1	-	23	3388	c.3013C>T	c.(3013-3015)Cgc>Tgc	p.R1005C	CEP128_ENST00000281129.3_Missense_Mutation_p.R1005C|CEP128_ENST00000553717.1_5'UTR			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	1005						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						GAATTTCTGCGAACCCTGTAT	0.348000													18	76					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539571	56539571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56539571C>T	ENST00000390649.3	+	7	1972	c.1972C>T	c.(1972-1974)Ccc>Tcc	p.P658S		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	658						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTGTCCCGTTCCCCTGGGGGT	0.587000													31	79					0	0	1	0	0
ESRP2	80004	broad.mit.edu	37	16	68266310	68266310	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68266310C>T	ENST00000473183.2	-	8	1456	c.918G>A	c.(916-918)caG>caA	p.Q306Q	ESRP2_ENST00000565858.1_Silent_p.Q316Q			Q9H6T0	ESRP2_HUMAN	epithelial splicing regulatory protein 2	316	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			NS(1)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	16						GCTTGTGTCTCTGCAGCGCTA	0.637000													15	65					0	0	1	0	0
ERVFRD-1	405754	broad.mit.edu	37	6	11104936	11104936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:11104936C>T	ENST00000472091.1	-	2	983	c.608G>A	c.(607-609)cGa>cAa	p.R203Q	SMIM13_ENST00000416247.2_Intron|ERVFRD-1_ENST00000542862.1_Missense_Mutation_p.R203Q	NM_207582.2	NP_997465.1	P60508	EFRD1_HUMAN		203						integral to membrane|plasma membrane|virion		p.R203Q(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(4)|stomach(1)	15						CCAGAAGTTTCGAGTACTGCA	0.463000													55	126					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100532314	100532314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100532314G>A	ENST00000457717.1	+	14	2040	c.1784G>A	c.(1783-1785)cGa>cAa	p.R595Q	RP11-766F14.1_ENST00000508578.1_RNA|MTTP_ENST00000265517.5_Missense_Mutation_p.R595Q|MTTP_ENST00000511045.1_Missense_Mutation_p.R622Q	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	595	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	ATTGTCCGTCGAGTTCTGAAG	0.398000													12	85					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152470822	152470822	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152470822G>A	ENST00000427231.2	-	77	11771	c.11569C>T	c.(11569-11571)Cag>Tag	p.Q3857*	NEB_ENST00000604864.1_Nonsense_Mutation_p.Q3857*|NEB_ENST00000603639.1_Nonsense_Mutation_p.Q3857*|NEB_ENST00000172853.10_Nonsense_Mutation_p.Q3614*|NEB_ENST00000397345.3_Nonsense_Mutation_p.Q3857*|NEB_ENST00000409198.1_Nonsense_Mutation_p.Q3614*	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3857					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCCGAGCCTGAATGACGTCA	0.473000													43	96					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134125725	134125725	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134125725G>A	ENST00000220616.4	+	44	7672	c.7632G>A	c.(7630-7632)caG>caA	p.Q2544Q	TG_ENST00000542445.1_Silent_p.Q914Q|TG_ENST00000519543.1_Silent_p.Q677Q|TG_ENST00000377869.1_Silent_p.Q2487Q	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2544					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGCACTGCAGAATTCTCTGG	0.498000													24	75					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94112962	94112962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94112962C>T	ENST00000553484.1	+	37	6390	c.6236C>T	c.(6235-6237)tCc>tTc	p.S2079F	UNC79_ENST00000555664.1_Missense_Mutation_p.S2018F|UNC79_ENST00000256339.4_Missense_Mutation_p.S1880F|UNC79_ENST00000393151.2_Missense_Mutation_p.S2057F			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2057						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AGATTGGCATCCAGTACTACC	0.393000													19	44					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9017436	9017436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9017436C>T	ENST00000397910.4	-	26	38091	c.37888G>A	c.(37888-37890)Gag>Aag	p.E12630K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12632	SEA 4.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATAGCTGCTCCCTGTCCACT	0.582000													17	180					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367196	107367196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107367196G>A	ENST00000542196.1	-	1	755	c.713C>T	c.(712-714)tCc>tTc	p.S238F		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ACAGGTAGAGGAAGCTTTGCT	0.398000													6	85					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893798	36893798	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36893798G>A	ENST00000301807.6	-	13	4703	c.2806C>T	c.(2806-2808)Cag>Tag	p.Q936*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.Q1486*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.Q936*	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1486					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAATAGAACTGAAGTAAATCC	0.418000													4	17					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75968884	75968884	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75968884C>T	ENST00000308508.5	-	10	6068	c.5976G>A	c.(5974-5976)gtG>gtA	p.V1992V	CTD-2026K11.1_ENST00000569467.1_RNA	NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1992	Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GCCGCCCGCCCACCAGGAGAT	0.617000													16	113					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34100921	34100921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34100921C>T	ENST00000373381.4	-	31	5155	c.4979G>A	c.(4978-4980)gGg>gAg	p.G1660E	CSMD2_ENST00000373380.1_Missense_Mutation_p.G533E|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1620	CUB 10.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ATACTGTCCCCCACAGGGGGC	0.552000											OREG0013349	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	32					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105258925	105258925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:105258925G>A	ENST00000306107.5	+	7	1337	c.837G>A	c.(835-837)gaG>gaA	p.E279E	ALCAM_ENST00000486979.2_Silent_p.E228E|ALCAM_ENST00000472644.2_Silent_p.E279E|ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000389927.4_Intron	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	279	Ig-like C2-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						CTCCCCCAGAGGAATTTTTGT	0.393000													20	188					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171080016	171080016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171080016C>T	ENST00000367755.4	+	6	816	c.705C>T	c.(703-705)ctC>ctT	p.L235L	FMO3_ENST00000538429.1_Silent_p.L172L|FMO3_ENST00000392085.2_Silent_p.L235L|FMO3_ENST00000542847.1_Silent_p.L215L	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	235					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACATGCTGCTCGTCACTCGAT	0.463000													67	159					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52269605	52269605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:52269605G>A	ENST00000354831.7	-	22	2587	c.2398C>T	c.(2398-2400)Ctt>Ttt	p.L800F	NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000539524.1_Missense_Mutation_p.L668F|NRD1_ENST00000544028.1_Missense_Mutation_p.L600F|NRD1_ENST00000352171.7_Missense_Mutation_p.L732F	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	731					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TTATGCGTAAGGATATTGACA	0.383000													5	47					0	0	1	0	0
SUCLG2	8801	broad.mit.edu	37	3	67570915	67570915	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:67570915G>A	ENST00000307227.5	-	5	588	c.561C>T	c.(559-561)ctC>ctT	p.L187L	SUCLG2_ENST00000493112.1_Silent_p.L187L|SUCLG2_ENST00000492795.1_Silent_p.L187L	NM_003848.3	NP_003839.2	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming, beta subunit	187	ATP-grasp.				succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	10		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	CCTTAAAAATGAGCTCCGGGT	0.498000													44	94					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76348532	76348532	+	Splice_Site	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76348532T>A	ENST00000312916.7	+	9	1749	c.1365_splice	c.e9-1	p.F456_splice		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	456	FHA.				angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		CTTTCTAAGTTTCATGCAGAA	0.299000													7	49					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96970536	96970536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96970536C>T	ENST00000341686.3	+	5	866	c.741C>T	c.(739-741)ttC>ttT	p.F247F	C10orf129_ENST00000394005.3_Silent_p.F247F|C10orf129_ENST00000430183.1_Silent_p.F92F	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	247					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GAATGGGATTCAGCCAGGCTT	0.493000													21	59					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248004718	248004718	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248004718G>A	ENST00000355784.2	-	1	536	c.481C>T	c.(481-483)Ctg>Ttg	p.L161L		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAAATCATCAGGGAAGGCAGA	0.557000													31	90					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77691833	77691833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77691833G>A	ENST00000296043.6	+	10	6357	c.5404G>A	c.(5404-5406)Ggg>Agg	p.G1802R	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1802	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GGAGGCGAAGGGGAGCCTGCT	0.552000													26	82					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20555588	20555588	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20555588C>T	ENST00000504154.1	+	26	2974	c.2722C>T	c.(2722-2724)Caa>Taa	p.Q908*	SLIT2_ENST00000273739.5_Nonsense_Mutation_p.Q912*|SLIT2_ENST00000503823.1_Nonsense_Mutation_p.Q900*|SLIT2_ENST00000503837.1_Nonsense_Mutation_p.Q904*	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	908	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ATTTACCTGTCAAGGTATGGT	0.338000													30	71					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197298091	197298091	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197298091G>A	ENST00000367400.3	+	2	745	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	CRB1_ENST00000538660.1_Missense_Mutation_p.E204K|CRB1_ENST00000367399.2_Missense_Mutation_p.E204K|CRB1_ENST00000535699.1_Missense_Mutation_p.E135K	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	204	EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATGCCTCAATGAAATAGGAAG	0.443000													15	38					0	0	1	0	0
KLK5	25818	broad.mit.edu	37	19	51446957	51446957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51446957C>T	ENST00000336334.3	-	6	1164	c.812G>A	c.(811-813)aGa>aAa	p.R271K	KLK5_ENST00000593428.1_Missense_Mutation_p.R271K|KLK5_ENST00000391809.2_Missense_Mutation_p.R271K	NM_012427.4	NP_036559.1	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5	271	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			NS(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		GACACCCGGTCTGTTGGGCCG	0.597000													20	86					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55045040	55045040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55045040C>T	ENST00000335056.3	+	3	198	c.160C>T	c.(160-162)Cgg>Tgg	p.R54W															p.R54W(1)		endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		TTCCCATCTTCGGTTTGTCAT	0.537000													13	29					0	0	1	0	0
ADAMTSL5	339366	broad.mit.edu	37	19	1510897	1510897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1510897G>A	ENST00000330475.4	-	2	489	c.46C>T	c.(46-48)Ctc>Ttc	p.L16F	ADAMTSL5_ENST00000413997.2_Missense_Mutation_p.L26F|ADAMTSL5_ENST00000395467.2_5'UTR|ADAMTSL5_ENST00000590562.1_5'UTR	NM_213604.2	NP_998769.2	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5	16						proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGAGCAGGAGGTTCTGGAAG	0.652000													5	13					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168812899	168812899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168812899C>T	ENST00000464456.1	-	11	3593	c.2393G>A	c.(2392-2394)aGa>aAa	p.R798K	MECOM_ENST00000433243.2_Missense_Mutation_p.R808K|MECOM_ENST00000472280.1_Missense_Mutation_p.R808K|MECOM_ENST00000392736.3_Missense_Mutation_p.R807K|MECOM_ENST00000494292.1_Missense_Mutation_p.R986K|MECOM_ENST00000468789.1_Missense_Mutation_p.R807K|MECOM_ENST00000264674.3_Missense_Mutation_p.R872K|MECOM_ENST00000460814.1_Missense_Mutation_p.R798K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						CTTTAGGTGTCTGTCTAAATT	0.343000													13	44					0	0	1	0	0
FAM13B	51306	broad.mit.edu	37	5	137284808	137284808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137284808G>A	ENST00000033079.3	-	17	2381	c.1930C>T	c.(1930-1932)Cca>Tca	p.P644S	FAM13B_ENST00000425075.2_Missense_Mutation_p.P548S|FAM13B_ENST00000420893.2_Missense_Mutation_p.P644S	NM_016603.2	NP_057687.2	Q9NYF5	FA13B_HUMAN	family with sequence similarity 13, member B	644					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(4)|kidney(2)|lung(5)	11						AAGCTTTTTGGAAGTGTGTTA	0.383000													54	119					0	0	1	0	0
TMEM163	81615	broad.mit.edu	37	2	135260556	135260556	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:135260556G>A	ENST00000281924.6	-	5	535	c.471C>T	c.(469-471)atC>atT	p.I157I		NM_030923.4	NP_112185.1	Q8TC26	TM163_HUMAN	transmembrane protein 163	157						integral to membrane				endometrium(1)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(221;0.154)		TCACCCCCAAGATGACACAGG	0.443000													12	18					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72146759	72146759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72146759G>A	ENST00000356056.5	-	35	6777	c.6305C>T	c.(6304-6306)tCg>tTg	p.S2102L	MYO9A_ENST00000424560.1_Missense_Mutation_p.S2173L|MYO9A_ENST00000564571.1_Missense_Mutation_p.S2102L|MYO9A_ENST00000444904.1_Missense_Mutation_p.S2083L	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	2102	Rho-GAP.|Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTTATTAGTCGAACCAGACTT	0.363000													83	259					0	0	1	0	0
KCNN4	3783	broad.mit.edu	37	19	44278616	44278616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44278616G>A	ENST00000262888.3	-	3	806	c.411C>T	c.(409-411)tcC>tcT	p.S137S		NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	137					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	AGGGCTGCGGGGAGGTCAGCG	0.731000											OREG0025535	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	10					0	0	1	0	0
CDK2AP1	8099	broad.mit.edu	37	12	123751787	123751787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123751787G>A	ENST00000542174.1	-	1	837	c.14C>T	c.(13-15)tCa>tTa	p.S5L	CDK2AP1_ENST00000544658.1_Missense_Mutation_p.S5L|CDK2AP1_ENST00000261692.2_Missense_Mutation_p.S33L|CDK2AP1_ENST00000538446.1_Missense_Mutation_p.S5L|CDK2AP1_ENST00000535979.1_Missense_Mutation_p.S5L			O14519	CDKA1_HUMAN	cyclin-dependent kinase 2 associated protein 1	33					DNA-dependent DNA replication|protein phosphorylation|S phase of mitotic cell cycle	cytoplasm|nucleus	DNA binding|protein binding			lung(2)|stomach(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000554)|Epithelial(86;0.00178)		GCGGTACTGTGAAGACGTTGC	0.622000													23	78					0	0	1	0	0
ZNF251	90987	broad.mit.edu	37	8	145947971	145947971	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145947971G>A	ENST00000292562.7	-	5	1349	c.1074C>T	c.(1072-1074)ttC>ttT	p.F358F	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		AGCTTCGACTGAAGGCCTTCC	0.507000													22	72					0	0	1	0	0
SEH1L	81929	broad.mit.edu	37	18	12982560	12982560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:12982560C>T	ENST00000262124.11	+	7	932	c.805C>T	c.(805-807)Cat>Tat	p.H269Y	SEH1L_ENST00000399892.2_Missense_Mutation_p.H269Y|SEH1L_ENST00000592582.1_3'UTR	NM_031216.3	NP_112493.2	Q96EE3	SEH1_HUMAN	SEH1-like (S. cerevisiae)	269					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	11						GTTTGAAATCCATATAGTGGC	0.383000													11	114					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30091926	30091926	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30091926G>A	ENST00000567636.1	+	0	301					NR_003558.1																						AACAGCTCATGATGGTTTGAG	0.448000													20	55					0	0	1	0	0
OR2T34	127068	broad.mit.edu	37	1	248737607	248737607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248737607G>A	ENST00000328782.2	-	1	473	c.452C>T	c.(451-453)tCa>tTa	p.S151L		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCAGCAGGCTGACACCAGGAG	0.517000													16	30					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584153	82584153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82584153C>T	ENST00000423517.2	-	5	6453	c.6116G>A	c.(6115-6117)aGc>aAc	p.S2039N	PCLO_ENST00000333891.8_Missense_Mutation_p.S2039N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1970					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TATCTCATGGCTTTCTGGGAT	0.388000													5	61					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92543146	92543146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92543146C>T	ENST00000298047.6	+	12	9402	c.9385C>T	c.(9385-9387)Cct>Tct	p.P3129S	FAT3_ENST00000525166.1_Missense_Mutation_p.P2979S|FAT3_ENST00000409404.2_Missense_Mutation_p.P3129S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3129	Cadherin 28.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGATAACCCCCCTGTGTTTTC	0.542000										TCGA Ovarian(4;0.039)			24	57					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117788609	117788609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117788609C>T	ENST00000276204.6	+	43	4814	c.4740C>T	c.(4738-4740)atC>atT	p.I1580I	DOCK11_ENST00000276202.7_Silent_p.I1580I			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1580	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CCAAGAGAATCCGCACTGTTC	0.418000													40	19					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111965556	111965556	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111965556G>A	ENST00000369732.3	-	6	656	c.601C>T	c.(601-603)Cta>Tta	p.L201L	OVGP1_ENST00000540696.1_Silent_p.L141L|OVGP1_ENST00000481495.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	201					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CACCTTCCTAGAAAGCGCACA	0.557000													112	248					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227895176	227895176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227895176C>T	ENST00000396625.3	-	41	4163	c.3956G>A	c.(3955-3957)gGa>gAa	p.G1319E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1319E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1319	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GCCATCTTTTCCATCACATCC	0.522000													35	118					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124413966	124413966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124413966G>A	ENST00000409039.3	+	70	12122	c.12097G>A	c.(12097-12099)Gag>Aag	p.E4033K	DNAH10OS_ENST00000514254.2_3'UTR|CCDC92_ENST00000544798.1_Intron	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4033	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGTGGTGCAGGAGAGAAGGAA	0.517000													7	27					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609301	84609301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84609301G>A	ENST00000344803.2	+	4	3963	c.3916G>A	c.(3916-3918)Gga>Aga	p.G1306R		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AGAGCTTGATGGAGGGGATGC	0.532000													6	27					0	0	1	0	0
MICU3	286097	broad.mit.edu	37	8	16935309	16935309	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16935309C>T	ENST00000318063.5	+	4	627	c.585C>T	c.(583-585)ctC>ctT	p.L195L		NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		ATCAAATGCTCGCAGAAACAC	0.313000													13	46					0	0	1	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452023	43452023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43452023G>A	ENST00000282388.3	-	2	1213	c.920C>T	c.(919-921)tCc>tTc	p.S307F	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	307					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GGAGGCCgaggaacaggagga	0.781000													5	6					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30602580	30602580	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30602580G>A	ENST00000358107.4	-	10	2096	c.2097C>T	c.(2095-2097)ttC>ttT	p.F699F	MTPAP_ENST00000263063.3_Silent_p.F569F|MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	569					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						TGGTTTTTGTGAAATTTTCTG	0.363000													55	132					0	0	1	0	0
DGKZ	8525	broad.mit.edu	37	11	46398761	46398761	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:46398761C>T	ENST00000454345.1	+	26	3030	c.2906_splice	c.e26+1	p.R969_splice	DGKZ_ENST00000543978.1_Splice_Site_p.R133_splice|DGKZ_ENST00000395574.3_Splice_Site_p.R747_splice|DGKZ_ENST00000318201.8_Splice_Site_p.R758_splice|DGKZ_ENST00000532868.2_Splice_Site_p.R785_splice|DGKZ_ENST00000456247.2_Splice_Site_p.R780_splice|DGKZ_ENST00000527911.1_Splice_Site_p.R781_splice|DGKZ_ENST00000528615.1_Splice_Site_p.R559_splice|DGKZ_ENST00000421244.2_Splice_Site_p.R781_splice|DGKZ_ENST00000343674.6_Splice_Site_p.R797_splice	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	969					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		ACCCACGCCCCGGTGAGTCCT	0.637000													14	15					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72190375	72190375	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:72190375C>T	ENST00000555818.1	+	16	4631	c.4283C>T	c.(4282-4284)tCc>tTc	p.S1428F	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.S1407F|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.S1407F|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.S882F	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1428	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACCATGAGCTCCCGACACTCT	0.547000													27	78					0	0	1	0	0
EVX1	2128	broad.mit.edu	37	7	27284711	27284711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27284711G>A	ENST00000496902.4	+	2	958	c.472G>A	c.(472-474)Gag>Aag	p.E158K	EVX1-AS_ENST00000517726.1_RNA|EVX1_ENST00000222761.3_Silent_p.A139A|EVX1_ENST00000535619.1_5'UTR			P49640	EVX1_HUMAN	even-skipped homeobox 1	158						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|liver(1)|lung(10)|prostate(1)|skin(1)	14						CGGAGGGAGCGAGACCCCCAA	0.667000													31	54					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98866842	98866842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98866842G>A	ENST00000477737.1	+	20	2939	c.2735G>A	c.(2734-2736)gGa>gAa	p.G912E	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	912										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AACCCCCAAGGAGCCAAACTC	0.408000													30	86					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063965	9063965	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9063965G>A	ENST00000397910.4	-	3	23684	c.23481C>T	c.(23479-23481)tcC>tcT	p.S7827S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7829	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGTCAGGGAGGAAGCTAGCT	0.542000													24	59					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67431935	67431935	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67431935C>T	ENST00000349015.3	-	8	1243	c.805G>A	c.(805-807)Gag>Aag	p.E269K	ALDH3B2_ENST00000530069.1_Missense_Mutation_p.E269K	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	269					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	TTGATGGCCTCGTCCACGCTC	0.652000													46	89					0	0	1	0	0
OR4C12	283093	broad.mit.edu	37	11	50003147	50003147	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:50003147C>T	ENST00000335238.4	-	1	924	c.891G>A	c.(889-891)agG>agA	p.R297R		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						TCCAAAGCTTCCTTATTGCAC	0.353000													10	33					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7334709	7334709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7334709G>A	ENST00000318881.6	+	3	818	c.581G>A	c.(580-582)gGa>gAa	p.G194E	SYT9_ENST00000396716.2_Missense_Mutation_p.G162E	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	194						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CAGTTGACTGGAATTGGTAGA	0.413000													9	93					0	0	1	0	0
ZNF491	126069	broad.mit.edu	37	19	11917576	11917576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11917576C>T	ENST00000323169.5	+	3	1139	c.808C>T	c.(808-810)Cct>Tct	p.P270S	ZNF491_ENST00000492230.1_Intron	NM_152356.3	NP_689569.2	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(14)|lung(6)|ovary(2)|skin(1)	26						TGGAGAGAGGCCTCATAAATG	0.408000													23	75					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168289904	168289904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:168289904C>T	ENST00000366806.2	+	7	1049	c.907C>T	c.(907-909)Cct>Tct	p.P303S	MLLT4_ENST00000351017.4_Missense_Mutation_p.P303S|MLLT4_ENST00000392108.3_Missense_Mutation_p.P303S|MLLT4_ENST00000392112.1_Missense_Mutation_p.P302S|MLLT4_ENST00000344191.4_Missense_Mutation_p.P303S|MLLT4_ENST00000400822.3_Missense_Mutation_p.P302S|MLLT4_ENST00000447894.2_Missense_Mutation_p.P303S			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	303	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GGTTATGCTTCCTCCTGGAGC	0.333000			T	MLL	AL								44	55					0	0	1	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182869233	182869233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:182869233C>T	ENST00000367547.3	-	10	2083	c.1847G>A	c.(1846-1848)gGa>gAa	p.G616E	SHCBP1L_ENST00000423786.1_Missense_Mutation_p.G497E|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	688										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						TTTTTTATCTCCTGAAGAAGC	0.343000													15	21					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164393656	164393656	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164393656G>A	ENST00000280605.3	-	1	1391	c.1231C>T	c.(1231-1233)Caa>Taa	p.Q411*		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	411						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ATATTGGCTTGAGAAATGGCT	0.498000													18	32					0	0	1	0	0
TARS2	80222	broad.mit.edu	37	1	150471471	150471471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150471471C>T	ENST00000369064.3	+	12	1534	c.1500C>T	c.(1498-1500)ggC>ggT	p.G500G	TARS2_ENST00000606933.1_Silent_p.G418G|TARS2_ENST00000369054.2_Silent_p.G370G|TARS2_ENST00000463555.1_3'UTR|TARS2_ENST00000438568.2_3'UTR	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	500					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	GGCCATCTGGCTTCCTGGGGG	0.562000													10	125					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39895225	39895225	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39895225G>A	ENST00000373186.4	-	1	230	c.93C>T	c.(91-93)ggC>ggT	p.G31G	MOCS1_ENST00000373188.2_Intron|MOCS1_ENST00000308559.7_Intron|MOCS1_ENST00000432280.2_Intron|MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000340692.5_Intron|MOCS1_ENST00000373175.4_Intron|MOCS1_ENST00000425303.2_Silent_p.G31G	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	29	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGAAGCATGGGCCCCTGCTAC	0.637000													9	11					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130343086	130343086	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130343086C>T	ENST00000299164.2	+	8	2223	c.2223C>T	c.(2221-2223)ttC>ttT	p.F741F		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	741	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		ACGGGCATTTCGTGGTGTCGG	0.637000													31	56					0	0	1	0	0
CHST3	9469	broad.mit.edu	37	10	73768064	73768064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73768064C>T	ENST00000373115.4	+	3	1712	c.1275C>T	c.(1273-1275)ttC>ttT	p.F425F		NM_004273.4	NP_004264.2	Q7LGC8	CHST3_HUMAN	carbohydrate (chondroitin 6) sulfotransferase 3	425					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity			endometrium(1)|lung(5)	6						CGGAGCAGTTCGAGAAGTGGC	0.652000													5	5					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25261739	25261739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25261739C>T	ENST00000395990.2	-	17	2031	c.1774G>A	c.(1774-1776)Gaa>Aaa	p.E592K	CASC1_ENST00000537577.1_Intron|CASC1_ENST00000395987.3_Missense_Mutation_p.E638K|CASC1_ENST00000354189.5_Intron|CASC1_ENST00000320267.9_Missense_Mutation_p.E632K|CASC1_ENST00000545133.1_Missense_Mutation_p.E573K	NM_001204102.1	NP_001191031.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	632										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			GTACATGCTTCAGTAAGGTGT	0.363000													8	21					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52159647	52159647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52159647G>A	ENST00000354534.5	+	16	2915	c.2737G>A	c.(2737-2739)Gaa>Aaa	p.E913K	SCN8A_ENST00000545061.1_Missense_Mutation_p.E913K|SCN8A_ENST00000550891.1_Missense_Mutation_p.E913K	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	913					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CCAGGACTGTGAACTCCCTCG	0.488000													66	115					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227465	38227465	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38227465C>T	ENST00000373048.4	-	3	461	c.462G>A	c.(460-462)acG>acA	p.T154T	EPHA10_ENST00000319637.6_Silent_p.T154T|EPHA10_ENST00000427468.2_Silent_p.T154T	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	154						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCGCCGCGATCGTGTCGATTT	0.662000													23	31					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819601	159819601	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159819601G>A	ENST00000497452.1	-	0	517																											GAATCTGGAGGAAAACTGACC	0.423000													94	214					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45322706	45322706	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45322706A>G	ENST00000391955.1	+	12	1621	c.1577A>G	c.(1576-1578)aAc>aGc	p.N526S	BCAM_ENST00000270233.6_Missense_Mutation_p.N526S			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	526	Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GAAGCCTCCAACCCCCACGGG	0.647000													28	71					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103427792	103427792	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103427792C>T	ENST00000358392.2	-	40	3407	c.3090G>A	c.(3088-3090)ggG>ggA	p.G1030G	COL11A1_ENST00000512756.1_Silent_p.G902G|COL11A1_ENST00000353414.4_Silent_p.G979G|COL11A1_ENST00000370096.3_Silent_p.G1018G	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1018	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTCCATCTTTCCCTGAGATAC	0.383000													41	77					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123519851	123519851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:123519851G>A	ENST00000422452.2	-	29	5815	c.5752C>T	c.(5752-5754)Ctg>Ttg	p.L1918L	TENM1_ENST00000371130.3_Silent_p.L1911L|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		ACTGAGAGCAGACAATCTGGT	0.498000													24	18					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44680451	44680451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44680451C>T	ENST00000590089.1	+	7	1403	c.1036C>T	c.(1036-1038)Cgt>Tgt	p.R346C	ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000454662.2_Missense_Mutation_p.R346C|ZNF226_ENST00000337433.5_Missense_Mutation_p.R346C			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				AGGTTTCAGTCGTAGATCAGC	0.463000													37	93					0	0	1	0	0
TMEM207	131920	broad.mit.edu	37	3	190158179	190158179	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:190158179C>T	ENST00000354905.2	-	4	225		c.e4-1			NM_207316.1	NP_997199.1	Q6UWW9	TM207_HUMAN	transmembrane protein 207							integral to membrane				endometrium(1)|large_intestine(2)|lung(4)	7	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)		CAGGAGGATCCTGACTCCAAA	0.517000													7	25					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26203890	26203890	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26203890G>A	ENST00000264712.3	-	1	1476	c.897C>T	c.(895-897)gcC>gcT	p.A299A	KIF3C_ENST00000405914.1_Silent_p.A299A	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	299	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTTGCCCAGGGCAGATAATG	0.637000													10	42					0	0	1	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16852153	16852153	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:16852153G>A	ENST00000437538.2	-	2	214	c.206C>T	c.(205-207)cCa>cTa	p.P69L	TNFRSF13B_ENST00000583789.1_Missense_Mutation_p.P69L|TNFRSF13B_ENST00000579315.1_Missense_Mutation_p.P115L|TNFRSF13B_ENST00000581616.2_5'UTR|TNFRSF13B_ENST00000261652.2_Missense_Mutation_p.P115L			O14836	TR13B_HUMAN	tumor necrosis factor receptor superfamily, member 13B	115					cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|skin(1)	16						GAGCTCTGGTGGAAGGTTCAC	0.527000									IgA Deficiency, Selective				71	84					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108129689	108129689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108129689C>T	ENST00000273353.3	-	32	4352	c.4296G>A	c.(4294-4296)caG>caA	p.Q1432Q		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1432						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CCAGCTGCAGCTGGTGCCTGG	0.622000													17	41					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210411339	210411339	+	Missense_Mutation	SNP	G	G	A	rs146773666		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210411339G>A	ENST00000367012.3	+	2	264	c.34G>A	c.(34-36)Gag>Aag	p.E12K	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	12							protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TAGATTCTGCGAGCCCATTGT	0.483000													38	102					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63529377	63529377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:63529377G>A	ENST00000550760.3	+	2	291	c.112G>A	c.(112-114)Gga>Aga	p.G38R	RP11-3N2.13_ENST00000445978.1_RNA	NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	38	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						AGAGAACTACGGAAACCTGTT	0.388000													25	18					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212752	62212752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:62212752G>A	ENST00000519846.1	+	3	838	c.366G>A	c.(364-366)ctG>ctA	p.L122L	CLVS1_ENST00000325897.4_Silent_p.L122L|RP11-787D18.1_ENST00000518064.1_RNA|CLVS1_ENST00000518592.1_Intron			Q8IUQ0	CLVS1_HUMAN	clavesin 1	122	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						AGAGGGCTCTGATCGATGGGT	0.488000													15	52					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72399970	72399970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:72399970C>T	ENST00000340595.3	+	15	2371	c.2175C>T	c.(2173-2175)ttC>ttT	p.F725F	SLC4A4_ENST00000425175.1_Silent_p.F769F|SLC4A4_ENST00000264485.5_Silent_p.F769F|SLC4A4_ENST00000351898.6_Silent_p.F769F	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	769						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity	p.F725F(2)|p.F769F(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GAGGTTGGTTCGTTCCACCGT	0.423000													19	47					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75969356	75969356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75969356C>T	ENST00000274364.6	+	25	3448	c.3151C>T	c.(3151-3153)Ctg>Ttg	p.L1051L	IQGAP2_ENST00000396234.3_Silent_p.L547L|IQGAP2_ENST00000502745.1_Silent_p.L547L|IQGAP2_ENST00000379730.3_Silent_p.L553L	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1051	Ras-GAP.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CATTGAGAACCTGAGAAGGGT	0.418000													10	117					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11994845	11994845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:11994845C>T	ENST00000333796.3	-	1	1741	c.1425G>A	c.(1423-1425)atG>atA	p.M475I	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	475					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						GATGGTTTTTCATCCCACACT	0.493000													24	15					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563735	176563735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176563735G>A	ENST00000367662.3	+	3	2159	c.995G>A	c.(994-996)gGa>gAa	p.G332E	PAPPA2_ENST00000367661.3_Missense_Mutation_p.G332E	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	332					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AAGGACAAGGGAAAGCGGGAT	0.562000													15	62					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41739911	41739911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:41739911G>A	ENST00000242208.4	-	2	308	c.62C>T	c.(61-63)tCc>tTc	p.S21F	INHBA-AS1_ENST00000420821.1_RNA|INHBA-AS1_ENST00000415848.2_RNA|INHBA_ENST00000442711.1_Missense_Mutation_p.S21F|INHBA-AS1_ENST00000422822.1_RNA|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	21					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						TGGGGTGGGGGAACTCCTCAC	0.567000										TSP Lung(11;0.080)			87	180					0	0	1	0	0
INTS10	55174	broad.mit.edu	37	8	19703292	19703292	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:19703292C>T	ENST00000397977.3	+	16	2358	c.1960C>T	c.(1960-1962)Caa>Taa	p.Q654*		NM_018142.2	NP_060612.2	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	654					snRNA processing	integrator complex	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	20				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		ACTACCCAATCAAGGAATGCT	0.398000													15	52					0	0	1	0	0
MS4A6E	245802	broad.mit.edu	37	11	60105379	60105379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60105379C>T	ENST00000300182.4	+	2	378	c.313C>T	c.(313-315)Cct>Tct	p.P105S		NM_139249.2	NP_640342.1	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member 6E	105						integral to membrane	receptor activity			endometrium(2)|kidney(1)|lung(9)|stomach(1)	13						TTATCATTCACCTTACACCAT	0.408000													30	92					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935344	151935344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151935344G>A	ENST00000393902.3	-	3	1390	c.823C>T	c.(823-825)Cca>Tca	p.P275S	MAGEA3_ENST00000370278.3_Missense_Mutation_p.P275S			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	275	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGCCCTTGGACCCCACAGG	0.532000													73	52					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34030707	34030707	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34030707G>A	ENST00000389232.4	+	50	7642	c.7572G>A	c.(7570-7572)tgG>tgA	p.W2524*	RYR3_ENST00000415757.3_Nonsense_Mutation_p.W2524*	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2524	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTTCAGGATGGGGGAGCTACG	0.512000											OREG0023032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	47					0	0	1	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086747	46086747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46086747G>A	ENST00000360770.3	-	1	97	c.57C>T	c.(55-57)ccC>ccT	p.P19P	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	19	23 X 5 AA approximate repeats.					keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						CTGGCTGGCAGGGGCTGGGCG	0.657000													8	25					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39435943	39435943	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39435943G>A	ENST00000257408.4	+	2	1036	c.939G>A	c.(937-939)acG>acA	p.T313T		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	313	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						CGGAAAACACGATGGATATAT	0.468000													24	65					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8871662	8871662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:8871662G>A	ENST00000256707.3	-	30	4685	c.4504C>T	c.(4504-4506)Ctc>Ttc	p.L1502F	KIDINS220_ENST00000427284.1_Missense_Mutation_p.L1483F|KIDINS220_ENST00000418530.1_Missense_Mutation_p.L1403F|KIDINS220_ENST00000473731.1_Missense_Mutation_p.L1483F	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1502					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTCTGGAAGAGGCTTGACCTT	0.473000													19	46					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189706760	189706760	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189706760G>A	ENST00000319332.5	-	4	1088	c.891C>T	c.(889-891)cgC>cgT	p.R297R	LEPREL1_ENST00000427335.2_Silent_p.R116R	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	297					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGGGAGAGAGGCGGCCAGGGC	0.507000													18	96					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80750645	80750645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80750645C>T	ENST00000458043.2	+	48	5949	c.5943C>T	c.(5941-5943)ttC>ttT	p.F1981F	OTOGL_ENST00000546620.1_5'UTR|OTOGL_ENST00000547103.1_Silent_p.F1969F	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						AAGATCAATTCATGATTCAAG	0.348000													15	24					0	0	1	0	0
TMEM245	23731	broad.mit.edu	37	9	111812952	111812952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111812952G>A	ENST00000374586.3	-	13	1906	c.1875C>T	c.(1873-1875)atC>atT	p.I625I		NM_032012.3	NP_114401.2	Q9H330	CI005_HUMAN	transmembrane protein 245	625						integral to membrane											GGCTCATAACGATCCACAGAG	0.458000													15	37					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48269841	48269841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48269841C>T	ENST00000225964.5	-	29	2096	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	660	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	CTTACCTGTTCACCAGGTTTG	0.582000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						9	21					0	0	1	0	0
G6PD	2539	broad.mit.edu	37	X	153761272	153761272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153761272G>A	ENST00000393562.2	-	9	1409	c.1026C>T	c.(1024-1026)ccC>ccT	p.P342P	G6PD_ENST00000393564.2_Silent_p.P312P|G6PD_ENST00000369620.2_Silent_p.P358P	NM_000402.3	NP_000393.4	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase	312			L -> F (in Chinese-5).		cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(3)|ovary(4)	18	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTCTCCATCGGGGTTCCCCA	0.612000													8	60					0	0	1	0	0
TMPPE	643853	broad.mit.edu	37	3	33134930	33134930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33134930G>A	ENST00000342462.4	-	2	948	c.758C>T	c.(757-759)tCg>tTg	p.S253L	GLB1_ENST00000399402.3_Intron|GLB1_ENST00000445488.2_Intron|GLB1_ENST00000307363.5_Intron|GLB1_ENST00000307377.8_Intron|TMPPE_ENST00000416695.2_Missense_Mutation_p.S116L	NM_001039770.2	NP_001034859.2	Q6ZT21	TMPPE_HUMAN	transmembrane protein with metallophosphoesterase domain	253						integral to membrane	metal ion binding			breast(1)|large_intestine(5)|lung(6)|prostate(1)	13						CCGCAGGACCGAGGCTTCTGA	0.547000													24	97					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38927686	38927686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38927686C>T	ENST00000302328.3	-	16	3077	c.2879G>A	c.(2878-2880)aGa>aAa	p.R960K	SCN11A_ENST00000456224.3_Intron|SCN11A_ENST00000444237.2_Missense_Mutation_p.R960K|SCN11A_ENST00000450244.1_Missense_Mutation_p.R960K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	960					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ACTTTGAACTCTCTGGCTCGT	0.448000													21	61					0	0	1	0	0
TRIM35	23087	broad.mit.edu	37	8	27151776	27151776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27151776G>A	ENST00000305364.4	-	3	666	c.583C>T	c.(583-585)Cgc>Tgc	p.R195C	TRIM35_ENST00000521253.1_Missense_Mutation_p.R163C	NM_171982.3	NP_741983.2	Q9UPQ4	TRI35_HUMAN	tripartite motif containing 35	195					apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding	p.R195C(1)		breast(1)|endometrium(6)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	14		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		AAGAACTCGCGAAGCTTATCA	0.577000													14	58					0	0	1	0	0
PYROXD1	79912	broad.mit.edu	37	12	21614955	21614955	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21614955C>T	ENST00000538582.1	+	9	1434	c.681C>T	c.(679-681)gtC>gtT	p.V227V	PYROXD1_ENST00000545178.1_3'UTR|PYROXD1_ENST00000240651.9_Silent_p.V298V			Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 1	298							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|soft_tissue(1)	18						TGTGGCCTGTCTATGTGGAAT	0.368000													27	48					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21205122	21205122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21205122G>A	ENST00000381541.3	+	10	1489	c.1424G>A	c.(1423-1425)gGa>gAa	p.G475E	SLCO1B7_ENST00000554957.1_Missense_Mutation_p.G475E|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.G428E|SLCO1B3_ENST00000553473.1_Intron																							CCCGTCTGTGGAAACAATGGA	0.378000													37	96					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151509770	151509770	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151509770C>T	ENST00000271636.7	+	21	3693	c.3560C>T	c.(3559-3561)tCg>tTg	p.S1187L		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	1181	Tail.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TACGATCCCTCGTCCATTGCA	0.552000													19	65					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52714852	52714852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52714852C>T	ENST00000293670.3	-	1	330	c.268G>A	c.(268-270)Gag>Aag	p.E90K		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	90	Head.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGAGGCTCTCGTTGACCGAC	0.667000													32	108					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75036942	75036942	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75036942C>T	ENST00000326665.5	-	14	4670	c.4452G>A	c.(4450-4452)agG>agA	p.R1484R	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1484	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GACTCAATTCCCTCTCTCCCT	0.542000													69	159					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10648094	10648094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10648094C>T	ENST00000547195.1	-	8	1014	c.514G>A	c.(514-516)Gac>Aac	p.D172N	MRVI1_ENST00000541483.1_Intron|MRVI1_ENST00000421747.1_Missense_Mutation_p.D254N|MRVI1_ENST00000423302.2_Missense_Mutation_p.D263N|MRVI1_ENST00000436272.1_Missense_Mutation_p.D236N|MRVI1_ENST00000534266.2_5'UTR|MRVI1_ENST00000424001.1_5'UTR|MRVI1_ENST00000531107.1_Missense_Mutation_p.D255N|MRVI1_ENST00000527509.2_Missense_Mutation_p.D172N|MRVI1_ENST00000558540.1_5'UTR|MRVI1_ENST00000552103.1_Missense_Mutation_p.D172N|MRVI1_ENST00000545852.1_5'UTR	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	236	Interaction with PRKG1 (By similarity).				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTCCTCTGGTCATTCTGCTTC	0.532000													8	21					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35245491	35245491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:35245491G>A	ENST00000360310.1	-	18	3034	c.2467C>T	c.(2467-2469)Ctc>Ttc	p.L823F	BAZ1A_ENST00000382422.2_Missense_Mutation_p.L823F|BAZ1A_ENST00000358716.4_Missense_Mutation_p.L791F	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	823	Interaction with SMARCA5.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TCAATAAAGAGTCCAGGAATA	0.413000													46	94					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129249780	129249780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129249780G>A	ENST00000296271.3	+	2	517	c.423G>A	c.(421-423)aaG>aaA	p.K141K		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	141					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	TGGTGTGTAAGCCCATGAGCA	0.637000													47	166					0	0	1	0	0
PLBD1	79887	broad.mit.edu	37	12	14706316	14706316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14706316G>A	ENST00000240617.5	-	2	798	c.146C>T	c.(145-147)cCt>cTt	p.P49L		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	49					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						CTTTTCAGCAGGCATCCAGTA	0.408000													19	90					0	0	1	0	0
BANP	54971	broad.mit.edu	37	16	88066771	88066771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:88066771C>T	ENST00000393207.1	+	9	1317	c.1096C>T	c.(1096-1098)Ccg>Tcg	p.P366S	BANP_ENST00000479780.2_Missense_Mutation_p.P335S|BANP_ENST00000538234.1_Missense_Mutation_p.P374S|BANP_ENST00000393208.2_Missense_Mutation_p.P335S|BANP_ENST00000355163.5_Missense_Mutation_p.P341S|BANP_ENST00000286122.7_Missense_Mutation_p.P366S|BANP_ENST00000355022.4_Missense_Mutation_p.P335S	NM_001173543.1	NP_001167014.1	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein	366	DNA-binding (By similarity).|Gln-rich.				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.00551)		ACAGCCGCAGCCGCAGGCCCT	0.627000													7	27					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551382	35551382	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35551382G>A	ENST00000262626.2	+	8	1411	c.586G>A	c.(586-588)Gac>Aac	p.D196N	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Intron|HPN_ENST00000392226.1_Missense_Mutation_p.D196N	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	196	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity	p.D196Y(1)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GCTCTCCGGGGACTGGGTGCT	0.672000													37	95					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16032714	16032714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16032714G>A	ENST00000350896.3	-	3	396	c.199C>T	c.(199-201)Ctc>Ttc	p.L67F	MSR1_ENST00000381998.4_Missense_Mutation_p.L67F|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000262101.5_Missense_Mutation_p.L67F|MSR1_ENST00000445506.2_Missense_Mutation_p.L85F|MSR1_ENST00000355282.2_Missense_Mutation_p.L67F	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	67					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTCCAATGAGAGGGATGAGA	0.418000													7	81					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53421577	53421577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53421577C>T	ENST00000262056.9	+	7	1005	c.679C>T	c.(679-681)Cgt>Tgt	p.R227C	EIF4B_ENST00000416762.3_Missense_Mutation_p.R188C|RP11-983P16.4_ENST00000552905.1_RNA|EIF4B_ENST00000420463.3_Missense_Mutation_p.R227C	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	227	Arg-rich.|Asp-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity	p.R227C(1)		breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						GTATCGAGATCGTTATGATTC	0.483000													22	133					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970347	101970347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:101970347C>T	ENST00000543253.1	+	5	1469	c.550C>T	c.(550-552)Cct>Tct	p.P184S	GPRASP2_ENST00000332262.5_Missense_Mutation_p.P184S|GPRASP2_ENST00000535209.1_Missense_Mutation_p.P184S	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						TGAAACCTTTCCTGGCACCCA	0.532000													78	43					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139873744	139873744	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139873744G>A	ENST00000224167.2	+	3	399	c.324G>A	c.(322-324)cgG>cgA	p.R108R	PTGDS_ENST00000371625.3_Silent_p.R108R|PTGDS_ENST00000460340.1_3'UTR			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	108					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ACAGCTACCGGAGTCCCCGTG	0.692000													23	63					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156819153	156819153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156819153G>A	ENST00000368195.3	-	6	1725	c.1329C>T	c.(1327-1329)gcC>gcT	p.A443A	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	443					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCGGGTTGAAGGCGAAGTAGA	0.602000													43	106					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665972	19665972	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19665972G>A	ENST00000328041.6	+	12	1488	c.1291G>A	c.(1291-1293)Gat>Aat	p.D431N		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	431						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						cgaggatgatgatgaagGACC	0.512000													31	62					0	0	1	0	0
DUSP26	78986	broad.mit.edu	37	8	33454988	33454988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:33454988G>A	ENST00000256261.4	-	2	563	c.46C>T	c.(46-48)Cgc>Tgc	p.R16C	DUSP26_ENST00000523956.1_Missense_Mutation_p.R16C	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	16						Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		CGGGAGAAGCGGGCCATAAAA	0.542000													7	39					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2191098	2191098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2191098G>A	ENST00000381178.1	-	3	205	c.187C>T	c.(187-189)Ccg>Tcg	p.P63S	TH_ENST00000352909.3_Missense_Mutation_p.P32S|TH_ENST00000381175.1_Missense_Mutation_p.P59S|TH_ENST00000333684.5_Missense_Mutation_p.P36S	NM_199292.2	NP_954986.2	P07101	TY3H_HUMAN	tyrosine hydroxylase	63					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(7)|skin(1)	11		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	ATGAACCGCGGGGACTGTGGG	0.716000													4	12					0	0	1	0	0
DUPD1	338599	broad.mit.edu	37	10	76803681	76803681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76803681C>T	ENST00000338487.5	-	2	294	c.295G>A	c.(295-297)Gac>Aac	p.D99N		NM_001003892.1	NP_001003892.1	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase domain containing 1	99	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CGGTAGTAGTCGGGCCCAGTG	0.667000													31	55					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94946066	94946066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94946066C>T	ENST00000222381.3	-	3	412	c.181G>A	c.(181-183)Gga>Aga	p.G61R	PON1_ENST00000542556.1_Missense_Mutation_p.G61R	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	61					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AAAGCCAGTCCATTAGGCAGT	0.403000													35	148					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61932087	61932087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61932087G>A	ENST00000280772.1	-	21	2648	c.2457C>T	c.(2455-2457)acC>acT	p.T819T	ANK3_ENST00000503366.1_Silent_p.T802T|ANK3_ENST00000373827.2_Silent_p.T813T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	819					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGGTCTCTTCGGTCACTATCT	0.483000													19	75					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75829083	75829083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:75829083C>T	ENST00000322507.8	-	45	7502	c.7193G>A	c.(7192-7194)gGa>gAa	p.G2398E	COL12A1_ENST00000483888.2_Missense_Mutation_p.G2398E|COL12A1_ENST00000416123.2_Missense_Mutation_p.G2398E|COL12A1_ENST00000345356.6_Missense_Mutation_p.G1234E	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2398	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TGTGTTTCCTCCTCTGTACCT	0.438000													18	142					0	0	1	0	0
RTF1	23168	broad.mit.edu	37	15	41769408	41769408	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41769408C>T	ENST00000389629.4	+	13	1618	c.1606C>T	c.(1606-1608)Caa>Taa	p.Q536*		NM_015138.4	NP_055953.3	Q92541	RTF1_HUMAN	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	536					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	18		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		CAAACAAATCCAAGATCAACT	0.512000													47	179					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123215752	123215752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123215752G>A	ENST00000349780.4	-	21	2954	c.2775C>T	c.(2773-2775)ctC>ctT	p.L925L	CDK5RAP2_ENST00000360190.4_Silent_p.L925L|CDK5RAP2_ENST00000359309.3_Silent_p.L925L|CDK5RAP2_ENST00000360822.3_Silent_p.L893L	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	925					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						TAATACCAGGGAGGGAAAGGA	0.453000													36	90					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12725998	12725998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12725998C>T	ENST00000376221.1	+	4	476	c.476C>T	c.(475-477)tCc>tTc	p.S159F		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	159						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GACCACCATTCCCCTGCCCTT	0.527000													24	86					0	0	1	0	0
MATN2	4147	broad.mit.edu	37	8	99039822	99039822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:99039822C>T	ENST00000254898.5	+	14	2352	c.2121C>T	c.(2119-2121)ttC>ttT	p.F707F	MATN2_ENST00000524308.1_Silent_p.F666F|MATN2_ENST00000522025.2_Silent_p.F423F|MATN2_ENST00000521689.1_Silent_p.F707F|MATN2_ENST00000520016.1_Silent_p.F707F|RPL30_ENST00000518164.1_Intron	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	707	VWFA 2.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			ACACAGAGTTCACTCTGAGAA	0.488000													10	51					0	0	1	0	0
KCTD18	130535	broad.mit.edu	37	2	201371607	201371607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:201371607G>A	ENST00000359878.3	-	2	643	c.133C>T	c.(133-135)Cgc>Tgc	p.R45C	KCTD18_ENST00000468413.1_5'UTR|KCTD18_ENST00000409157.1_Missense_Mutation_p.R45C	NM_152387.2	NP_689600.2	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain containing 18	45	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						AGAGGAAAGCGACCACTGAAC	0.433000													27	58					0	0	1	0	0
DDX20	11218	broad.mit.edu	37	1	112305305	112305305	+	Missense_Mutation	SNP	C	C	T	rs61755354		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112305305C>T	ENST00000369702.4	+	9	1731	c.1111C>T	c.(1111-1113)Cgt>Tgt	p.R371C	DDX20_ENST00000475700.1_5'UTR|DDX20_ENST00000536167.1_3'UTR	NM_007204.4	NP_009135.4	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	371	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAGACTTCTCGTGGGATTGA	0.403000													17	125					0	0	1	0	0
T	6862	broad.mit.edu	37	6	166581001	166581001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:166581001C>T	ENST00000296946.2	-	2	547	c.79G>A	c.(79-81)Gag>Aag	p.E27K	T_ENST00000366871.3_Missense_Mutation_p.E27K	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	27					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GCCTGCAGCTCATTCTCCACG	0.682000									Chordoma, Familial Clustering of				7	9					0	0	1	0	0
UBL7	84993	broad.mit.edu	37	15	74740913	74740913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74740913G>A	ENST00000567435.1	-	10	1374	c.911C>T	c.(910-912)tCc>tTc	p.S304F	UBL7_ENST00000395081.2_Missense_Mutation_p.S304F|UBL7_ENST00000361351.4_Missense_Mutation_p.S304F|UBL7_ENST00000564488.1_Missense_Mutation_p.S304F|UBL7_ENST00000565335.1_Missense_Mutation_p.S304F			Q96S82	UBL7_HUMAN	ubiquitin-like 7 (bone marrow stromal cell-derived)	304							protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9						GACACCAGAGGACATTGGTGA	0.552000													79	293					0	0	1	0	0
IGHV7-81	28378	broad.mit.edu	37	14	107283249	107283249	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107283249G>A	ENST00000390639.2	-	0	31																											TGCTCTAGGGGATTCTCCCAA	0.507000													27	49					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16918926	16918926	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16918926G>A	ENST00000524140.2	+	18	4684	c.4266G>A	c.(4264-4266)tgG>tgA	p.W1422*	NWD1_ENST00000523826.1_Nonsense_Mutation_p.W1216*|NWD1_ENST00000379808.3_Nonsense_Mutation_p.W1422*|NWD1_ENST00000552788.1_Nonsense_Mutation_p.W1422*|NWD1_ENST00000339803.6_Nonsense_Mutation_p.W1287*|NWD1_ENST00000549814.1_Nonsense_Mutation_p.W1380*	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1422							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CACGCAAGTGGAAATTCGAGA	0.567000													23	51					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43351612	43351612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43351612C>T	ENST00000395891.1	+	4	883	c.278C>T	c.(277-279)tCt>tTt	p.S93F	HECW1_ENST00000453890.1_Missense_Mutation_p.S93F	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	93					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						ATCGGGCACTCTCAGGACCTG	0.567000													26	74					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72946126	72946126	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72946126C>T	ENST00000311131.2	+	3	1389	c.922C>T	c.(922-924)Ctg>Ttg	p.L308L	P2RY2_ENST00000393597.2_Silent_p.L308L|P2RY2_ENST00000393596.2_Silent_p.L308L	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	308					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	GCTCTACTTCCTGGCTGGGCA	0.662000													9	29					0	0	1	0	0
ZNF512B	57473	broad.mit.edu	37	20	62594450	62594450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62594450G>A	ENST00000450537.1	-	12	2026	c.1966C>T	c.(1966-1968)Ccc>Tcc	p.P656S	ZNF512B_ENST00000369888.1_Missense_Mutation_p.P656S|ZNF512B_ENST00000217130.3_Missense_Mutation_p.P656S			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	656					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCACTCACGGGGGCCGTGTGC	0.622000													3	8					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	51053096	51053096	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:51053096G>A	ENST00000442544.2	+	28	4837	c.4221G>A	c.(4219-4221)gaG>gaA	p.E1407E	DCC_ENST00000581580.1_Silent_p.E1040E|RP11-671P2.1_ENST00000582064.1_RNA	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1407					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AAGTGTCTGAGGAGAGCCACA	0.483000													8	89					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703417	4703417	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4703417G>A	ENST00000396950.3	-	2	764	c.525C>T	c.(523-525)caC>caT	p.H175H		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CACAATAGGAGTGCGAGAGGA	0.532000													28	70					0	0	1	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458239	20458239	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20458239G>A	ENST00000426804.1	-	1	3547	c.3063C>T	c.(3061-3063)ccC>ccT	p.P1021P		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			ATACCACATGGGGGTGGCGGT	0.627000													7	11					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129929579	129929579	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129929579C>T	ENST00000222481.4	+	11	1307	c.1252C>T	c.(1252-1254)Ccc>Tcc	p.P418S		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	418					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					GCGAGACCACCCCTATTAGGG	0.522000													28	64					0	0	1	0	0
TBK1	29110	broad.mit.edu	37	12	64854024	64854024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:64854024C>T	ENST00000331710.5	+	3	482	c.143C>T	c.(142-144)cCa>cTa	p.P48L		NM_013254.3	NP_037386.1	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	48	Protein kinase.				I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)	20				GBM - Glioblastoma multiforme(28;0.0386)		TTCCTTCGTCCAGTGGATGTT	0.269000													32	62					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219249890	219249890	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219249890G>A	ENST00000233202.6	+	4	634	c.294G>A	c.(292-294)tgG>tgA	p.W98*	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	98					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCTGCTCTGGGCCACCGTGT	0.622000													9	90					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005674	74005674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74005674C>T	ENST00000301607.3	-	22	3865	c.3612G>A	c.(3610-3612)ccG>ccA	p.P1204P	EVPL_ENST00000586740.1_Silent_p.P1226P	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1204	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCTCTGTCTCCGGATCCACCT	0.627000													28	64					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28983403	28983403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28983403G>A	ENST00000359747.4	+	11	1471	c.1442G>A	c.(1441-1443)gGa>gAa	p.G481E	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.G481E|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	481	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACAGCTACAGGAACCATATGT	0.398000													13	26					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158609717	158609717	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158609717G>A	ENST00000368148.3	-	34	4998	c.4818C>T	c.(4816-4818)gcC>gcT	p.A1606A	SPTA1_ENST00000368147.3_Silent_p.A1606A	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1606					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTGACGACTGGCCTCATTGA	0.473000													42	116					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27321123	27321123	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27321123G>A	ENST00000407991.1	-	6	1445	c.837C>T	c.(835-837)atC>atT	p.I279I	CHRNA2_ENST00000520933.2_Silent_p.I279I|CHRNA2_ENST00000240132.2_Silent_p.I264I	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	279			I -> N (in ENFL4; markedly increases receptor sensitivity to acetylcholine).			cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	TGAGGCAGGAGATGAGCAGGC	0.607000													16	44					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233486	21233486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21233486C>T	ENST00000233242.1	-	26	6381	c.6254G>A	c.(6253-6255)cGa>cAa	p.R2085Q		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2085	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATGGTTTGTCGATTCCTCTC	0.348000													21	77					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046521	73046521	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73046521C>T	ENST00000604411.1	+	0	34482				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TTCTATCCTTCCTGGGTTCTG	0.468000													81	52					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7661052	7661052	+	Silent	SNP	T	T	G	rs56030009		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7661052T>G	ENST00000299492.4	+	15	1714	c.1326T>G	c.(1324-1326)ccT>ccG	p.P442P	PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000533792.1_Silent_p.P284P|PPFIBP2_ENST00000528883.1_Silent_p.P330P|PPFIBP2_ENST00000530181.1_Silent_p.P299P	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	442					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCAAATCTCCTCCCACCATCT	0.597000													40	136					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133051060	133051060	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133051060T>A	ENST00000262283.5	-	11	1292	c.1193A>T	c.(1192-1194)gAc>gTc	p.D398V	OC90_ENST00000443356.2_Missense_Mutation_p.D202V|OC90_ENST00000254627.3_Missense_Mutation_p.D202V|OC90_ENST00000603859.1_Missense_Mutation_p.D202V			Q02509	OC90_HUMAN	otoconin 90	202	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TGTTGTCAAGTCTTCCTTGAT	0.517000													8	21					0	0	1	0	0
USP8	9101	broad.mit.edu	37	15	50785001	50785001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50785001C>T	ENST00000433963.1	+	16	2838	c.2338C>T	c.(2338-2340)Cgt>Tgt	p.R780C	USP8_ENST00000307179.4_Missense_Mutation_p.R780C|USP8_ENST00000425032.3_Missense_Mutation_p.R674C|USP8_ENST00000396444.3_Missense_Mutation_p.R780C	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	780					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TACTGGACTTCGTAACTTAGG	0.403000													38	107					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50959005	50959005	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50959005C>T	ENST00000374103.4	-	7	861	c.776G>A	c.(775-777)tGg>tAg	p.W259*	OGDHL_ENST00000419399.1_Nonsense_Mutation_p.W202*|OGDHL_ENST00000432695.1_Nonsense_Mutation_p.W50*	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	259					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CTCTGAGGACCATTTCCGGGC	0.562000													5	17					0	0	1	0	0
GPR87	53836	broad.mit.edu	37	3	151012587	151012587	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151012587G>A	ENST00000260843.4	-	3	911	c.447C>T	c.(445-447)gaC>gaT	p.D149D	MED12L_ENST00000491549.1_Intron|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_023915.3	NP_076404.3	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	149						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(6)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	19			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACATCCGAGAGTCCCCAAATG	0.418000													13	62					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645297	52645297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:52645297C>T	ENST00000395961.3	-	4	523	c.357G>A	c.(355-357)gtG>gtA	p.V119V	BCAS1_ENST00000371435.2_Silent_p.V119V|BCAS1_ENST00000371440.3_Silent_p.V119V|BCAS1_ENST00000411563.1_Silent_p.V22V	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	119						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CATCAAGCTTCACTGATCCAA	0.537000													21	64					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7678627	7678627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7678627C>T	ENST00000572933.1	+	30	6248	c.4788C>T	c.(4786-4788)ttC>ttT	p.F1596F	DNAH2_ENST00000389173.2_Silent_p.F1596F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1596	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACATTGACTTCCTCCACTCAG	0.547000													11	14					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7175787	7175787	+	Missense_Mutation	SNP	G	G	A	rs142773314		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7175787G>A	ENST00000406697.1	+	14	1851	c.1223G>A	c.(1222-1224)aGc>aAc	p.S408N	C1S_ENST00000328916.3_Missense_Mutation_p.S408N|C1S_ENST00000402681.3_Missense_Mutation_p.S241N|C1S_ENST00000495061.1_3'UTR|C1S_ENST00000360817.5_Missense_Mutation_p.S408N			P09871	C1S_HUMAN	complement component 1, s subcomponent	408	Sushi 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GGTAACGGGAGCTGGGTGAAT	0.582000													15	27					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93902868	93902868	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:93902868G>A	ENST00000412050.4	-	6	1417	c.1329C>T	c.(1327-1329)atC>atT	p.I443I	CPEB3_ENST00000265997.4_Silent_p.I457I	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	457	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				AGCTGGCAGTGATCTCATCTA	0.358000													14	35					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74276746	74276746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74276746C>T	ENST00000262765.5	-	10	4131	c.3952G>A	c.(3952-3954)Gag>Aag	p.E1318K		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1318							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						ACATCGATCTCCATCTCCAGG	0.587000													18	78					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87241867	87241867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87241867C>T	ENST00000297524.3	-	1	743	c.640G>A	c.(640-642)Gga>Aga	p.G214R	SLC7A13_ENST00000419776.2_Missense_Mutation_p.G214R|SLC7A13_ENST00000520624.1_Intron	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	214						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						GCAAAATATCCTTGGAAGATG	0.368000													43	100					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171535411	171535411	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171535411A>G	ENST00000367742.3	+	21	6399	c.6157A>G	c.(6157-6159)Act>Gct	p.T2053A	PRRC2C_ENST00000426496.2_Missense_Mutation_p.T2051A|PRRC2C_ENST00000338920.4_Missense_Mutation_p.T2051A|PRRC2C_ENST00000392078.3_Missense_Mutation_p.T2053A			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2051							protein C-terminus binding										CGAAATTGGAACTGACACAAT	0.373000													6	22					0	0	1	0	0
PDCD1	5133	broad.mit.edu	37	2	242794827	242794827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242794827G>A	ENST00000334409.5	-	2	451	c.382C>T	c.(382-384)Ctg>Ttg	p.L128L		NM_005018.2	NP_005009.2	Q15116	PDCD1_HUMAN	programmed cell death 1	128	Ig-like V-type.				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			endometrium(1)|lung(2)|ovary(1)|prostate(3)|skin(1)	8		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		TTGGGGGCCAGGGAGATGGCC	0.677000													15	41					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31606075	31606075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31606075C>T	ENST00000170150.3	+	8	783	c.588C>T	c.(586-588)ccC>ccT	p.P196P		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	196						extracellular region	lipid binding										GCCTCAACCCCGTGGGTCCTG	0.478000													18	73					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101868335	101868335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101868335G>A	ENST00000263468.8	+	11	3585	c.3315G>A	c.(3313-3315)aaG>aaA	p.K1105K	KIAA1377_ENST00000537689.1_Silent_p.K906K	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	1105							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TCCAGGAGAAGAGAGAAGATA	0.428000													7	78					0	0	1	0	0
PEG10	23089	broad.mit.edu	37	7	94293537	94293537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94293537C>T	ENST00000482108.1	+	2	1148	c.669C>T	c.(667-669)gtC>gtT	p.V223V	PEG10_ENST00000488574.1_Silent_p.V223V	NM_001040152.1|NM_001172438.1|NM_001184962.1	NP_001035242.1|NP_001165909.1|NP_001171891.1	Q86TG7	PEG10_HUMAN	paternally expressed 10	223	Necessary for interaction with ALK1.				apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding	p.V223V(1)		NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(9)|prostate(3)|skin(1)	21	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			ACCTCGAGGTCGCCAAGTCGC	0.627000													48	55					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119953070	119953070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119953070C>T	ENST00000307142.4	+	4	3336	c.3140C>T	c.(3139-3141)tCc>tTc	p.S1047F	SYNPO2_ENST00000429713.2_Missense_Mutation_p.S1047F|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Missense_Mutation_p.S1047F	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	1047						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GTCAGTGCATCCCCAGTGCCT	0.532000													19	53					0	0	1	0	0
RNF10	9921	broad.mit.edu	37	12	120992561	120992561	+	Missense_Mutation	SNP	C	C	T	rs138704590		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120992561C>T	ENST00000325954.4	+	4	1056	c.595C>T	c.(595-597)Cat>Tat	p.H199Y	RNF10_ENST00000413266.2_Missense_Mutation_p.H199Y	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	199					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTACACAGCTCATTTTGCTGA	0.428000													40	149					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38531037	38531037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38531037G>A	ENST00000332509.3	-	6	1035	c.852C>T	c.(850-852)ccC>ccT	p.P284P	PLA2G6_ENST00000335539.3_Silent_p.P284P|PLA2G6_ENST00000402064.1_Silent_p.P284P	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	284					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	CTCCGTAACGGGGGTCTTTGC	0.657000													20	58					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058960	152058960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152058960G>A	ENST00000368806.1	-	3	1262	c.1198C>T	c.(1198-1200)Cat>Tat	p.H400Y		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	400							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GCTGTTCCATGGGCCTCAGGA	0.473000													68	160					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70064186	70064186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70064186C>T	ENST00000370598.1	+	27	4342	c.3521C>T	c.(3520-3522)tCg>tTg	p.S1174L	BAI3_ENST00000546190.1_Missense_Mutation_p.S138L|BAI3_ENST00000238918.8_Missense_Mutation_p.S380L	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1174	Poly-Ser.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GCAGATTCTTCGAGTTCGTTT	0.393000													61	68					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489255	237489255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:237489255C>T	ENST00000272928.3	+	2	457	c.147C>T	c.(145-147)ttC>ttT	p.F49F		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		CGCTCTCCTTCATTTACATTT	0.527000													8	20					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103787	53103787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:53103787C>T	ENST00000408890.4	+	1	439	c.423C>T	c.(421-423)atC>atT	p.I141I		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	141										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCATCGGGATCGCGCCCCCTG	0.716000													19	42					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5890243	5890243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:5890243G>A	ENST00000581347.1	-	3	2465	c.1820C>T	c.(1819-1821)tCt>tTt	p.S607F	TMEM200C_ENST00000383490.2_Missense_Mutation_p.S607F|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	607						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						TATGGCATGAGACCTGGAAAT	0.547000													38	100					0	0	1	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249106434	249106434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:249106434G>A	ENST00000366472.5	-	7	2076	c.847C>T	c.(847-849)Ccc>Tcc	p.P283S	SH3BP5L_ENST00000411742.2_Missense_Mutation_p.P251S|SH3BP5L_ENST00000475978.1_5'UTR	NM_030645.1	NP_085148.1	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	283										endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGGCCCAGGGGGTGGGGAGGC	0.716000													6	21					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435305	18435305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18435305C>T	ENST00000433979.1	+	2	406	c.290C>T	c.(289-291)tCc>tTc	p.S97F	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.S97F|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.S97F|PIK3C2G_ENST00000535651.1_Missense_Mutation_p.S97F|RERGL_ENST00000541632.1_Intron	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	97					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CGTGAACTCTCCTGGCATCAA	0.423000													30	115					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712534	121712534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121712534G>A	ENST00000273691.3	-	6	1035	c.930C>T	c.(928-930)ctC>ctT	p.L310L	ILDR1_ENST00000462014.1_Silent_p.L322L|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000393631.1_Silent_p.L265L|ILDR1_ENST00000344209.5_Silent_p.L354L	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	354						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GAATTGGGGTGAGCCACTGCT	0.602000													15	35					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52822006	52822006	+	Silent	SNP	C	C	T	rs145881645	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52822006C>T	ENST00000273283.2	+	17	1953	c.1929C>T	c.(1927-1929)ttC>ttT	p.F643F	ITIH1_ENST00000540715.1_Silent_p.F501F|ITIH1_ENST00000542827.1_Intron|ITIH1_ENST00000537050.1_Silent_p.F355F|ITIH1_ENST00000405128.3_Silent_p.F9F	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	643	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity	p.F643L(1)|p.F643F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		CATCAGCGTTCGTGCTGTCAG	0.612000													38	121					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71015363	71015363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71015363C>T	ENST00000393567.2	-	29	4591	c.4441G>A	c.(4441-4443)Gaa>Aaa	p.E1481K		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1481										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GTGATATTTTCTGGGTCCAGG	0.478000													29	67					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936693	4936693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4936693G>A	ENST00000322013.3	-	1	229	c.201C>T	c.(199-201)ttC>ttT	p.F67F	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCATGGACAGGAAGAGATACA	0.478000													18	40					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171092543	171092543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171092543C>T	ENST00000334231.6	+	7	673	c.673C>T	c.(673-675)Cgc>Tgc	p.R225C	MYO3B_ENST00000409044.3_Missense_Mutation_p.R216C|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000408978.4_Missense_Mutation_p.R216C			Q8WXR4	MYO3B_HUMAN	myosin IIIB	216	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						CTATGACGCTCGCTGTGACGT	0.493000											OREG0014376	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	110					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196759830	196759830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196759830G>A	ENST00000312428.6	-	30	4866	c.4766C>T	c.(4765-4767)tCc>tTc	p.S1589F		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1589	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATCTTCTCGGAAAAGAATGC	0.368000													24	61					0	0	1	0	0
LRRC10	376132	broad.mit.edu	37	12	70003892	70003892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70003892C>T	ENST00000361484.3	-	1	1050	c.727G>A	c.(727-729)Gag>Aag	p.E243K		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	243						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TCTGGCGTCTCCTCTGCCCAT	0.582000													15	63					0	0	1	0	0
MYOG	4656	broad.mit.edu	37	1	203054976	203054976	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203054976C>T	ENST00000241651.4	-	1	188	c.114G>A	c.(112-114)acG>acA	p.T38T		NM_002479.4	NP_002470.2	P15173	MYOG_HUMAN	myogenin (myogenic factor 4)	38					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|urinary_tract(1)	12						GGGTGAGCTCCGTCCGCTCGT	0.652000													20	48					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109707915	109707915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109707915C>T	ENST00000356711.2	+	27	3367	c.3241C>T	c.(3241-3243)Cgc>Tgc	p.R1081C	MYO16_ENST00000357550.2_Missense_Mutation_p.R1081C|MYO16_ENST00000457511.2_Missense_Mutation_p.R593C	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1081	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATACCCTGTTCGCCTTTCCTT	0.433000													29	132					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59272864	59272864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:59272864G>A	ENST00000320743.3	-	14	2111	c.1825C>T	c.(1825-1827)Ccc>Tcc	p.P609S	LRIG3_ENST00000379141.4_Missense_Mutation_p.P549S	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	609	Ig-like C2-type 2.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			AGATCCATGGGGGTCTTGGTG	0.527000			T	ROS1	NSCLC								19	30					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14563098	14563098	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14563098C>T	ENST00000273083.3	-	0	778							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CACCTCCCCCCATCCCAGGCC	0.582000													6	8					0	0	1	0	0
KRT38	8687	broad.mit.edu	37	17	39597070	39597070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39597070C>T	ENST00000246646.3	-	1	103	c.104G>A	c.(103-105)gGg>gAg	p.G35E		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	35	Head.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				GGCCTCTGCCCCAGGCTGGCA	0.617000													18	39					0	0	1	0	0
EYA2	2139	broad.mit.edu	37	20	45633599	45633599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45633599C>T	ENST00000327619.5	+	4	548	c.174C>T	c.(172-174)ctC>ctT	p.L58L	EYA2_ENST00000357410.3_Silent_p.L58L|EYA2_ENST00000317304.6_Silent_p.L58L	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	58					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				CACGTGTCCTCCCCCGCCAGC	0.572000													18	119					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650730	179650730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179650730C>T	ENST00000589042.1	-	14	2439	c.2215G>A	c.(2215-2217)Gaa>Aaa	p.E739K	TTN_ENST00000342992.6_Missense_Mutation_p.E739K|TTN_ENST00000360870.5_Missense_Mutation_p.E739K|TTN_ENST00000591111.1_Missense_Mutation_p.E739K|TTN_ENST00000342175.6_Missense_Mutation_p.E693K|TTN_ENST00000359218.5_Missense_Mutation_p.E693K|TTN_ENST00000460472.2_Missense_Mutation_p.E693K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	739							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAATGCGTTCCTTATATCCG	0.552000													29	69					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54913107	54913107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54913107C>T	ENST00000293373.6	+	16	1695	c.1616C>T	c.(1615-1617)tCt>tTt	p.S539F	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.S489F	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	539					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TCTGATCTGTCTACTTTCTGG	0.383000													35	98					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76397922	76397922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76397922C>T	ENST00000357063.3	+	16	4278	c.3018C>T	c.(3016-3018)gcC>gcT	p.A1006A	LMO7_ENST00000377534.3_Silent_p.A1006A|LMO7_ENST00000321797.8_Silent_p.A721A|LMO7_ENST00000526202.1_Silent_p.A571A|LMO7_ENST00000341547.4_Silent_p.A672A|LMO7_ENST00000465261.2_Silent_p.A721A			Q8WWI1	LMO7_HUMAN	LIM domain 7	1006						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		CTTCTAAAGCCACATTGTCTT	0.473000													8	71					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101818765	101818765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101818765C>T	ENST00000263468.8	+	4	668	c.398C>T	c.(397-399)tCc>tTc	p.S133F		NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	133							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TCTTTAGTTTCCCGAAAACCA	0.333000													9	66					0	0	1	0	0
MKKS	8195	broad.mit.edu	37	20	10393290	10393290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:10393290G>A	ENST00000347364.2	-	3	1635	c.873C>T	c.(871-873)gtC>gtT	p.V291V		NM_170784.2	NP_740754.1	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome	291	Substrate-binding apical domain.				brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding			kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|stomach(2)	16						TTTGGCACAGGACAAGATCTA	0.438000													30	80					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66931291	66931291	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:66931291G>A	ENST00000374690.3	+	4	2457	c.1933G>A	c.(1933-1935)Gag>Aag	p.E645K	AR_ENST00000396044.3_Missense_Mutation_p.E645K|AR_ENST00000396043.2_Missense_Mutation_p.E113K	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	644	Interaction with HIPK3 (By similarity).|Interaction with MYST2.		A -> D (in dbSNP:rs1800053).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GGAGGAAGGAGAGGCTTCCAG	0.473000									Androgen Insensitivity Syndrome				4	5					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79326248	79326248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79326248C>T	ENST00000376718.3	-	8	1065	c.942G>A	c.(940-942)caG>caA	p.Q314Q	PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	314					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GGCAAGGGTTCTGACACTCTT	0.488000													10	13					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124385898	124385898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124385898C>T	ENST00000360013.3	+	47	6695	c.6568C>T	c.(6568-6570)Ccc>Tcc	p.P2190S	KALRN_ENST00000459915.1_Missense_Mutation_p.P282S|KALRN_ENST00000428018.2_Missense_Mutation_p.P461S|KALRN_ENST00000393496.1_Missense_Mutation_p.P531S|KALRN_ENST00000291478.4_Missense_Mutation_p.P493S	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2189	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GGACAATGATCCCTGCAAGTT	0.433000													29	74					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135389715	135389715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135389715C>T	ENST00000442011.2	+	9	1371	c.1210C>T	c.(1210-1212)Ctc>Ttc	p.L404F	TGFBI_ENST00000305126.8_Missense_Mutation_p.L404F	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	404	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CGGCAATCATCTCTCTGGAAG	0.507000													31	126					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17353254	17353254	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:17353254G>A	ENST00000261381.6	-	3	588	c.504C>T	c.(502-504)ttC>ttT	p.F168F		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	168					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCCTGGGTGCGAAGTTGCTGT	0.498000													28	98					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6228309	6228309	+	Silent	SNP	G	G	A	rs146996909	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6228309G>A	ENST00000262450.3	-	2	207	c.108C>T	c.(106-108)ttC>ttT	p.F36F	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	36					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding	p.F36F(1)		breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AAAAGTCATCGAAGGCTTCAA	0.498000													84	189					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164679	139164679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139164679G>A	ENST00000395297.1	-	13	2209	c.2039C>T	c.(2038-2040)tCa>tTa	p.S680L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	680										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TATGATGGATGAAGATCTCTT	0.537000										HNSCC(54;0.14)			9	100					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382554	152382554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152382554C>T	ENST00000271835.3	-	3	1066	c.1004G>A	c.(1003-1005)aGg>aAg	p.R335K	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	335	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGTCTGGCTCCTGCCTTGACC	0.592000													74	190					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532019	50532019	+	Missense_Mutation	SNP	G	G	A	rs141342139	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50532019G>A	ENST00000374144.3	+	3	1717	c.1429G>A	c.(1429-1431)Gga>Aga	p.G477R	C10orf71_ENST00000323868.4_Missense_Mutation_p.G477R			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	477										endometrium(1)	1						ACAGCTAAACGGATACCAAGA	0.572000													7	26					0	0	1	0	0
CDK1	983	broad.mit.edu	37	10	62552004	62552004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:62552004C>T	ENST00000448257.2	+	7	953	c.752C>T	c.(751-753)tCc>tTc	p.S251F	CDK1_ENST00000395284.3_Missense_Mutation_p.S251F|CDK1_ENST00000373809.2_Missense_Mutation_p.S194F|CDK1_ENST00000316629.4_Missense_Mutation_p.S194F			P06493	CDK1_HUMAN	cyclin-dependent kinase 1	251	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|axon guidance|cell division|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|mitosis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein localization to kinetochore|Ras protein signal transduction|regulation of transcription involved in G1/S phase of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|midbody|nucleoplasm|spindle microtubule	ATP binding|cyclin-dependent protein kinase activity|RNA polymerase II carboxy-terminal domain kinase activity			ovary(1)	1						AGCCTAGCATCCCATGTCAAA	0.403000													27	53					0	0	1	0	0
PLA2G7	7941	broad.mit.edu	37	6	46672983	46672983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46672983C>T	ENST00000274793.7	-	11	1292	c.1096G>A	c.(1096-1098)Gga>Aga	p.G366R	PLA2G7_ENST00000537365.1_Missense_Mutation_p.G366R	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	366					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			AGCATGTGTCCAATTATTTTG	0.333000													9	64					0	0	1	0	0
STMN4	81551	broad.mit.edu	37	8	27097571	27097571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27097571C>T	ENST00000350889.4	-	6	621	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K	STMN4_ENST00000519997.1_Missense_Mutation_p.E134K|STMN4_ENST00000265770.7_Missense_Mutation_p.E143K|STMN4_ENST00000522908.1_Missense_Mutation_p.E170K|STMN4_ENST00000519614.1_Missense_Mutation_p.E143K|STMN4_ENST00000523048.1_Missense_Mutation_p.E170K	NM_030795.2	NP_110422.2	Q9H169	STMN4_HUMAN	stathmin-like 4	143					intracellular signal transduction					endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)	11		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		GCCAGTTTTTCCTTAGCCATC	0.527000													28	76					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903186	4903186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4903186C>T	ENST00000380378.1	+	1	138	c.138C>T	c.(136-138)ttC>ttT	p.F46F	MMP26_ENST00000477339.1_Intron|OR51T1_ENST00000322049.1_Silent_p.F19F|MMP26_ENST00000380390.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCACTGCATTCCCTGGGCTGG	0.423000													37	84					0	0	1	0	0
MFSD10	10227	broad.mit.edu	37	4	2935555	2935555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:2935555G>A	ENST00000329687.4	-	1	630	c.96C>T	c.(94-96)ctC>ctT	p.L32L	MFSD10_ENST00000507555.1_Silent_p.L32L|MFSD10_ENST00000508221.1_Silent_p.L32L|MFSD10_ENST00000355443.4_Silent_p.L32L|MFSD10_ENST00000514800.1_Silent_p.L32L	NM_001120.4	NP_001111.3	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing 10	32					apoptosis	integral to membrane	tetracycline transporter activity			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GGTCCAGCAGGAGGCCGAGAA	0.716000													4	4					0	0	1	0	0
RYK	6259	broad.mit.edu	37	3	133894509	133894509	+	Missense_Mutation	SNP	G	G	A	rs144378986	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133894509G>A	ENST00000427044.2	-	14	1562	c.952C>T	c.(952-954)Cgt>Tgt	p.R318C	RYK_ENST00000296084.4_Missense_Mutation_p.R508C			P34925	RYK_HUMAN	receptor-like tyrosine kinase	504					corpus callosum development|positive regulation of MAPKKK cascade|Wnt receptor signaling pathway	cytoplasm|integral to plasma membrane|nucleus	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(1)|ovary(3)	4						GCCATCCAACGAACTGGCCTG	0.473000													65	136					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903121	4903121	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4903121C>T	ENST00000380378.1	+	1	73	c.73C>T	c.(73-75)Caa>Taa	p.Q25*	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCAGTGTCTTCAACCAACCAT	0.338000													21	55					0	0	1	0	0
SULT1E1	6783	broad.mit.edu	37	4	70721023	70721023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70721023C>T	ENST00000226444.3	-	3	379	c.267G>A	c.(265-267)atG>atA	p.M89I		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	89					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						CGTTACCATTCATGAGGTTTT	0.318000													11	41					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94746701	94746701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:94746701G>A	ENST00000399300.2	-	3	2151	c.1938C>T	c.(1936-1938)ctC>ctT	p.L646L	RBM12B_ENST00000517700.1_Intron|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	646							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CCTCCTCGGGGAGCTGCCTGA	0.647000													26	146					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34962775	34962775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34962775G>A	ENST00000329357.5	+	1	1863	c.1827G>A	c.(1825-1827)aaG>aaA	p.K609K		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	609										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCATTGAAAAGCTGTTTGCCA	0.438000													89	70					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119106955	119106955	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119106955C>T	ENST00000328252.3	+	14	4114	c.3745C>T	c.(3745-3747)Cag>Tag	p.Q1249*	PAPPA_ENST00000534838.1_Nonsense_Mutation_p.Q287*	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1249	Sushi 1.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CTACGTGCTCCAGATACGGCG	0.582000													7	47					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120464920	120464920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120464920G>A	ENST00000256646.2	-	28	5371	c.5152C>T	c.(5152-5154)Cgc>Tgc	p.R1718C		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1718					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCATCTCGGCGAAGAGTGAAA	0.483000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				17	67					0	0	1	0	0
TBC1D22A	25771	broad.mit.edu	37	22	47193357	47193357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:47193357C>T	ENST00000337137.4	+	4	643	c.477C>T	c.(475-477)gcC>gcT	p.A159A	TBC1D22A_ENST00000380995.1_Silent_p.A112A|TBC1D22A_ENST00000406733.1_Silent_p.A112A|TBC1D22A_ENST00000407381.3_Intron|TBC1D22A_ENST00000355704.3_Intron	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	159						intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		CCAGCGATGCCGCCCCTCTGC	0.632000											OREG0026659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	128					0	0	1	0	0
HSF5	124535	broad.mit.edu	37	17	56557593	56557593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56557593G>A	ENST00000323777.3	-	2	695	c.586C>T	c.(586-588)Cgt>Tgt	p.R196C		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	196						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTATCTCGACGAAATGACCGG	0.433000													35	68					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142393656	142393656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:142393656G>A	ENST00000378004.3	+	12	1474	c.1119G>A	c.(1117-1119)tcG>tcA	p.S373S	ARHGAP26_ENST00000274498.4_Silent_p.S373S	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	373					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding	p.S373S(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCTACAACTCGAACAAAGACA	0.428000													13	85					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159618524	159618524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159618524C>T	ENST00000297267.9	+	2	371	c.171C>T	c.(169-171)gtC>gtT	p.V57V	FNDC1_ENST00000340366.6_Silent_p.V57V	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	57	Fibronectin type-III 1.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCTGAAAGTCACGTGGGACC	0.453000													21	95					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558038	140558038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140558038G>A	ENST00000239444.2	+	1	668	c.423G>A	c.(421-423)gtG>gtA	p.V141V		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		141	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGTTGGTGAAAGTATCAG	0.413000													33	105					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48382030	48382030	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48382030C>T	ENST00000224600.4	-	4	3732	c.3619G>A	c.(3619-3621)Gaa>Aaa	p.E1207K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1207	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CCCACCCCTTCCCAGGAGCTG	0.642000													32	52					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75115153	75115153	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:75115153C>T	ENST00000290573.2	+	16	2943	c.2343C>T	c.(2341-2343)atC>atT	p.I781I	HK2_ENST00000409174.1_Silent_p.I753I	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	781	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						CAAGGGGCATCTTTGAAACCA	0.512000													53	130					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71148051	71148051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71148051C>T	ENST00000283228.2	-	5	1110	c.658G>A	c.(658-660)Gac>Aac	p.D220N	PTPRR_ENST00000549308.1_5'UTR|PTPRR_ENST00000440835.2_5'UTR|PTPRR_ENST00000342084.4_Missense_Mutation_p.D108N|PTPRR_ENST00000378778.1_Missense_Mutation_p.D14N	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	220					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CAGATTTTGTCCGCTTCATGC	0.358000													19	39					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83218214	83218214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83218214G>A	ENST00000562833.1	-	5	598	c.599C>T	c.(598-600)cCa>cTa	p.P200L	CPEB1_ENST00000398592.2_Silent_p.P239P|CPEB1_ENST00000261723.6_Silent_p.P468P|CPEB1_ENST00000568757.1_Silent_p.P390P|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000563800.1_Silent_p.P492P|CPEB1_ENST00000562019.1_Silent_p.P470P|CPEB1_ENST00000398591.2_Silent_p.P395P|CPEB1_ENST00000568128.1_Silent_p.P465P|CPEB1_ENST00000450751.2_Silent_p.P390P|CPEB1_ENST00000423133.2_Silent_p.P390P|CPEB1_ENST00000564522.1_Silent_p.P390P																							ACTTACCAATGGGATACTTGT	0.517000													17	55					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144942442	144942442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144942442C>T	ENST00000525985.1	-	2	5051	c.4980G>A	c.(4978-4980)caG>caA	p.Q1660Q				P58107	EPIPL_HUMAN	epiplakin 1	1660						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGAGGGAGATCTGCTGCCCGG	0.642000													34	74					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7976251	7976251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7976251G>A	ENST00000319144.4	-	15	2204	c.1944C>T	c.(1942-1944)ttC>ttT	p.F648F		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	648	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						GAATGTCCGGGAAGTGTCCCA	0.687000										Multiple Myeloma(8;0.094)			10	14					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56511246	56511246	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56511246C>T	ENST00000302957.3	-	1	41	c.42G>A	c.(40-42)gtG>gtA	p.V14V		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CTTCCATGTCCACGGAGGTGA	0.408000													32	94					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74904519	74904519	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74904519C>T	ENST00000289575.5	+	9	1727	c.1332C>T	c.(1330-1332)gcC>gcT	p.A444A	SLCO2B1_ENST00000532236.1_Silent_p.A328A|SLCO2B1_ENST00000525650.1_Silent_p.A300A|SLCO2B1_ENST00000341411.4_Silent_p.A217A|SLCO2B1_ENST00000454962.2_Silent_p.A217A|SLCO2B1_ENST00000531756.1_Silent_p.A189A|SLCO2B1_ENST00000428359.2_Silent_p.A422A	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	444					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	GATGCGGTGCCCTTTGCCTGC	0.632000													12	41					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11009471	11009471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11009471G>A	ENST00000324288.8	+	14	3066	c.2933G>A	c.(2932-2934)cGg>cAg	p.R978Q	CIITA_ENST00000381835.5_Missense_Mutation_p.R394Q	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	978			Missing (in BLS2).		interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						AAACTGGTGCGGATCCTCACG	0.572000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								12	62					0	0	1	0	0
TRBV6-6	28601	broad.mit.edu	37	7	142162089	142162089	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142162089C>T	ENST00000390371.3	-	0	229																											AAATCAGCTTCAGCCCCATGC	0.478000													83	197					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064290	9064290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9064290G>A	ENST00000397910.4	-	3	23359	c.23156C>T	c.(23155-23157)tCa>tTa	p.S7719L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7721	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGAGAAGTGAAGTCACAGG	0.547000													34	70					0	0	1	0	0
CLDN17	26285	broad.mit.edu	37	21	31538872	31538872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31538872G>A	ENST00000286808.3	-	1	99	c.64C>T	c.(64-66)Ctt>Ttt	p.L22F		NM_012131.2	NP_036263.1	P56750	CLD17_HUMAN	claudin 17	22					calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(2)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	23						GTTGTGGCAAGAGTCCCCACC	0.483000													24	66					0	0	1	0	0
OCLN	100506658	broad.mit.edu	37	5	68800117	68800117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:68800117G>A	ENST00000355237.2	+	2	482	c.46G>A	c.(46-48)Gaa>Aaa	p.E16K	OCLN_ENST00000542132.1_5'UTR|OCLN_ENST00000396442.2_Missense_Mutation_p.E16K|OCLN_ENST00000538151.1_5'UTR|OCLN_ENST00000380766.2_Missense_Mutation_p.E16K	NM_002538.3	NP_002529.1	Q16625	OCLN_HUMAN	occludin	16					cellular component disassembly involved in apoptosis|protein complex assembly	integral to membrane|tight junction	protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|liver(1)|prostate(1)|skin(1)	6		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CAGGCCTGATGAATTGTAAGT	0.358000													12	24					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187192915	187192915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187192915C>T	ENST00000264692.4	+	3	541	c.208C>T	c.(208-210)Ccc>Tcc	p.P70S	F11_ENST00000403665.2_Missense_Mutation_p.P70S|F11_ENST00000492972.2_Missense_Mutation_p.P70S			P03951	FA11_HUMAN	coagulation factor XI	70	Apple 1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	ATCTGAGGATCCCACCCGATG	0.418000													28	97					0	0	1	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87329760	87329760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87329760G>A	ENST00000338056.3	+	4	724	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	RUNDC3B_ENST00000394654.3_Missense_Mutation_p.E88K|RUNDC3B_ENST00000493037.1_Missense_Mutation_p.E88K|ABCB1_ENST00000265724.3_Intron	NM_001134405.1|NM_138290.2	NP_001127877.1|NP_612147.1	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B	105	RUN.									breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(2)	26	Esophageal squamous(14;0.00164)					GTTTGGTTATGAAAGTCCTCG	0.343000													12	35					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141583073	141583073	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141583073G>A	ENST00000442267.2	-	10	1851	c.1777C>T	c.(1777-1779)Cga>Tga	p.R593*		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	593	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTGGGATTTCGAAAAGCATAA	0.398000													13	28					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168352575	168352575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:168352575C>T	ENST00000366806.2	+	30	4662	c.4520C>T	c.(4519-4521)tCg>tTg	p.S1507L	MLLT4_ENST00000351017.4_Missense_Mutation_p.S1514L|MLLT4_ENST00000392108.3_Missense_Mutation_p.S1507L|MLLT4_ENST00000392112.1_Missense_Mutation_p.S1490L|MLLT4_ENST00000344191.4_Missense_Mutation_p.S1507L|MLLT4_ENST00000400822.3_Missense_Mutation_p.S1506L|MLLT4_ENST00000447894.2_Missense_Mutation_p.S1507L			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	1507					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GAGCTTTCCTCGGGGGACAGT	0.592000			T	MLL	AL								16	35					0	0	1	0	0
RGS21	431704	broad.mit.edu	37	1	192321319	192321319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:192321319C>T	ENST00000417209.2	+	4	405	c.231C>T	c.(229-231)ttC>ttT	p.F77F		NM_001039152.3	NP_001034241.1	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	77	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			NS(1)|endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	15						ATTCTGAATTCATTGAAGCTG	0.388000													21	44					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47894564	47894564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47894564G>A	ENST00000289672.2	-	30	4825	c.4775C>T	c.(4774-4776)tCc>tTc	p.S1592F		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1592					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GGGGTTTTCGGAAAGCTCAGT	0.388000													32	94					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10721541	10721541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10721541C>T	ENST00000283025.2	-	7	1428	c.1357G>A	c.(1357-1359)Gag>Aag	p.E453K	TEKT5_ENST00000574923.1_5'UTR	NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	453					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule		p.E453K(1)		breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						ATGGCGAGCTCGTGCTCCAGC	0.637000													11	51					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196646781	196646781	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196646781G>A	ENST00000367429.4	+	5	843	c.603G>A	c.(601-603)gaG>gaA	p.E201E	CFH_ENST00000439155.2_Silent_p.E201E|CFH_ENST00000359637.2_Intron	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	201	Sushi 3.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GGAGTAAAGAGAAACCAAAGT	0.328000													30	144					0	0	1	0	0
MAP6	4135	broad.mit.edu	37	11	75319244	75319244	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75319244C>T	ENST00000434603.2	-	2	1093	c.1029G>A	c.(1027-1029)gaG>gaA	p.E343E	MAP6_ENST00000526740.1_Silent_p.E14E|MAP6_ENST00000304771.3_Silent_p.E343E	NM_207577.1	NP_997460.1	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6	343						Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	19	Ovarian(111;0.11)					GCTTGCTGGCCTCTCCTTTGA	0.498000													10	99					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50826513	50826513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50826513G>A	ENST00000376959.2	-	2	1860	c.1697C>T	c.(1696-1698)cCc>cTc	p.P566L	KCNC3_ENST00000391818.2_Intron|KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000477616.1_Missense_Mutation_p.P566L			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	566					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CGGTTGCGGGGGCCGGGGGAT	0.657000													9	13					0	0	1	0	0
KCNJ11	3767	broad.mit.edu	37	11	17408842	17408842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17408842G>A	ENST00000339994.4	-	1	1364	c.797C>T	c.(796-798)cCa>cTa	p.P266L	KCNJ11_ENST00000528731.1_Missense_Mutation_p.P179L	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	179						integral to membrane	ATP-activated inward rectifier potassium channel activity			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		GTCGTAGAGTGGGCTGTTGGC	0.607000											OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	76					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75150111	75150111	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75150111G>A	ENST00000356357.4	-	5	884	c.369C>T	c.(367-369)tcC>tcT	p.S123S	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		TTACTACGTTGGAATTGGGCT	0.488000													32	146					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39281897	39281897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:39281897G>A	ENST00000426016.1	-	6	664	c.578C>T	c.(577-579)cCt>cTt	p.P193L	SOS1_ENST00000395038.2_Missense_Mutation_p.P193L|SOS1_ENST00000402219.2_Missense_Mutation_p.P193L|SOS1_ENST00000428721.2_Missense_Mutation_p.P136L			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	193					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				TGAGGTGGAAGGCTCTTCGTC	0.279000									Noonan syndrome				44	137					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086197	92086197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92086197G>A	ENST00000298047.6	+	1	936	c.919G>A	c.(919-921)Gat>Aat	p.D307N	FAT3_ENST00000525166.1_Missense_Mutation_p.D157N|FAT3_ENST00000409404.2_Missense_Mutation_p.D307N|FAT3_ENST00000541502.1_Missense_Mutation_p.D307N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	307	Cadherin 3.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGTGGCTGGGGATCCTTTAGA	0.448000										TCGA Ovarian(4;0.039)			14	37					0	0	1	0	0
CRYGA	1418	broad.mit.edu	37	2	209025752	209025752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:209025752G>A	ENST00000304502.4	-	3	320	c.301C>T	c.(301-303)Ctt>Ttt	p.L101F		NM_014617.3	NP_055432.2			crystallin, gamma A											endometrium(1)|kidney(3)|large_intestine(1)|lung(7)	12				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		TCAGACATAAGGCCTCGGTAG	0.498000													30	55					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697549	6697549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6697549G>A	ENST00000245907.6	-	21	2694	c.2602C>T	c.(2602-2604)Cac>Tac	p.H868Y		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	868					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GCTGGATTGTGGAGTAGTTCC	0.592000													8	44					0	0	1	0	0
IGSF8	93185	broad.mit.edu	37	1	160062981	160062981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160062981G>A	ENST00000368086.1	-	4	1261	c.1045C>T	c.(1045-1047)Cct>Tct	p.P349S	IGSF8_ENST00000314485.7_Missense_Mutation_p.P349S			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	349	Ig-like C2-type 3.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCCCCCGCAGGTGCCATCTCC	0.662000													10	28					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921209	24921209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24921209C>T	ENST00000329468.2	+	1	669	c.195C>T	c.(193-195)ttC>ttT	p.F65F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1									p.F65F(1)									CCAGCATCTTCGTCGCCCCTA	0.721000													11	35					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416016	178416016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178416016C>T	ENST00000231188.5	-	6	1452	c.1274G>A	c.(1273-1275)gGg>gAg	p.G425E	GRM6_ENST00000517717.1_Missense_Mutation_p.G425E|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	425					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GCCTGTGTGCCCAGGGCAGAG	0.627000													6	29					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542887	14542887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14542887C>T	ENST00000358970.5	-	1	258	c.259G>A	c.(259-261)Gac>Aac	p.D87N	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	87										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGGAGTTGTCATGGTCTCCA	0.592000													72	320					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15661511	15661511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15661511C>T	ENST00000281171.4	+	7	1604	c.1274C>T	c.(1273-1275)tCa>tTa	p.S425L	PTPRO_ENST00000348962.2_Missense_Mutation_p.S425L|PTPRO_ENST00000543886.1_Missense_Mutation_p.S425L	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	425						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				GCAGGTCCTTCAGGAGAGTGG	0.458000													4	24					0	0	1	0	0
DDI2	84301	broad.mit.edu	37	1	15978206	15978206	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15978206C>T	ENST00000480945.1	+	8	1170	c.999C>T	c.(997-999)tcC>tcT	p.S333S		NM_032341.4	NP_115717.3	Q5TDH0	DDI2_HUMAN	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	333					proteolysis		aspartic-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|stomach(1)	17		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CCAAGTGTTCCATCGACCTGA	0.448000													16	52					0	0	1	0	0
OR1I1	126370	broad.mit.edu	37	19	15198013	15198013	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15198013T>A	ENST00000209540.2	+	1	223	c.137T>A	c.(136-138)aTc>aAc	p.I46N		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						GCCCTCATTATCCTGGCCATC	0.512000													28	52					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25308673	25308673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25308673G>A	ENST00000400358.4	+	22	2939	c.2882G>A	c.(2881-2883)gGa>gAa	p.G961E	SGSM1_ENST00000400359.4_Missense_Mutation_p.G1016E	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	1016	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TTCCCCCACGGAGGCGCCATG	0.507000													4	39					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28650782	28650782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28650782C>T	ENST00000280904.6	-	14	2603	c.2160G>A	c.(2158-2160)ggG>ggA	p.G720G	DSC2_ENST00000251081.6_Silent_p.G720G	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	720					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GTTTAGACGTCCCAGAAGCCC	0.388000													19	86					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108487953	108487953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108487953G>A	ENST00000408999.3	+	20	3570	c.3493G>A	c.(3493-3495)Gag>Aag	p.E1165K	RGPD4_ENST00000354986.4_Missense_Mutation_p.E1165K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1165	RanBD1 1.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						GCAGAAATTTGAGGAATGCCA	0.433000													22	203					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74658705	74658705	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74658705G>A	ENST00000334011.5	+	2	563	c.345G>A	c.(343-345)tgG>tgA	p.W115*		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	115						nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					GCTGTCTCTGGAACACCACGG	0.587000													19	51					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450542	158450542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158450542G>A	ENST00000368152.1	+	1	875	c.875G>A	c.(874-876)aGg>aAg	p.R292K	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					AACAAAGACAGGCTGGTGACG	0.458000													19	61					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54798615	54798615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54798615C>T	ENST00000293379.4	-	13	1550	c.1289G>A	c.(1288-1290)gGg>gAg	p.G430E	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	430					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						TCCTGGGCCCCCAGGAAATAC	0.617000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	36					0	0	1	0	0
IFNA7	3444	broad.mit.edu	37	9	21201733	21201733	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21201733C>T	ENST00000239347.3	-	1	471	c.432G>A	c.(430-432)agG>agA	p.R144R		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	144					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGAAGTATTTCCTCACAGCCA	0.448000													47	337					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7875820	7875820	+	Missense_Mutation	SNP	G	G	A	rs139675589		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:7875820G>A	ENST00000378789.3	-	5	824	c.773C>T	c.(772-774)tCg>tTg	p.S258L		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	258	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CCCATGATTCGACACCAAGAT	0.483000													33	71					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	132110663	132110663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132110663G>A	ENST00000404460.1	+	7	548	c.494G>A	c.(493-495)cGa>cAa	p.R165Q	PLEKHB2_ENST00000303908.3_Missense_Mutation_p.R165Q			Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	0						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		CTCCCAACGCGATGTTTTTTT	0.448000													13	26					0	0	1	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253688	32253688	+	Silent	SNP	G	G	A	rs143748718		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32253688G>A	ENST00000332378.4	-	1	186	c.156C>T	c.(154-156)ctC>ctT	p.L52L		NM_175858.2	NP_787054.1	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	52						keratin filament	structural molecule activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|pancreas(1)	18						AGTGGTCCAGGAGCCAAGAGC	0.572000													16	53					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99319926	99319926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99319926C>T	ENST00000336374.2	-	3	213	c.211G>A	c.(211-213)Gtc>Atc	p.V71I		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	71			V -> A (in dbSNP:rs45580339).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					CACCCCCAGACTTTTCTATAC	0.393000													8	87					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021437	132021437	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132021437C>T	ENST00000356920.5	+	15	2503	c.2409C>T	c.(2407-2409)atC>atT	p.I803I	PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	803	Actin-like.						ATP binding										AGCACCCCATCCTGCTGACCG	0.587000													66	161					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115371995	115371995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115371995C>T	ENST00000369358.4	-	30	3764	c.3520G>A	c.(3520-3522)Gag>Aag	p.E1174K	NRAP_ENST00000360478.3_Missense_Mutation_p.E1131K|NRAP_ENST00000359988.3_Missense_Mutation_p.E1166K|NRAP_ENST00000369360.3_Missense_Mutation_p.E1139K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1166						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CTCCTTACCTCACTCTGCAAT	0.542000													25	61					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167659342	167659342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167659342G>A	ENST00000367854.3	+	4	586	c.255G>A	c.(253-255)ctG>ctA	p.L85L	RCSD1_ENST00000537350.1_Silent_p.L55L	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	85								p.L85L(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					GCTCGCCTCTGATTGAGAAGC	0.423000													20	81					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103124179	103124179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103124179C>T	ENST00000428762.1	-	62	10261	c.10102G>A	c.(10102-10104)Ggg>Agg	p.G3368R	RELN_ENST00000424685.2_Missense_Mutation_p.G3368R|RELN_ENST00000343529.5_Missense_Mutation_p.G3368R|CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000473945.1_5'UTR	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3368					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGGTGATCCCGTTGTTGACG	0.557000													32	130					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215896555	215896555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215896555G>A	ENST00000272895.7	-	9	1270	c.1051C>T	c.(1051-1053)Ctg>Ttg	p.L351L	ABCA12_ENST00000389661.4_Silent_p.L33L|AC072062.3_ENST00000437897.3_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	351					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGTGCAGCCAGACTGCTTGGA	0.328000													49	122					0	0	1	0	0
ACTL7A	10881	broad.mit.edu	37	9	111624631	111624631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111624631G>A	ENST00000333999.3	+	1	29	c.29G>A	c.(28-30)gGg>gAg	p.G10E		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	10						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GCAATCATGGGGGATGGGCCC	0.597000													22	63					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37710234	37710234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37710234C>T	ENST00000400485.1	+	4	526	c.450C>T	c.(448-450)ttC>ttT	p.F150F	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	150					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						TAGTGGCATTCAACAAGCACC	0.378000													53	116					0	0	1	0	0
RNF10	9921	broad.mit.edu	37	12	121002954	121002954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121002954C>T	ENST00000325954.4	+	11	2206	c.1745C>T	c.(1744-1746)cCt>cTt	p.P582L	RNF10_ENST00000413266.2_Missense_Mutation_p.P587L	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	582					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTTTGCAACCTCCTGTGGTC	0.478000													16	128					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151970819	151970819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151970819G>A	ENST00000355193.2	-	7	1201	c.983C>T	c.(982-984)cCa>cTa	p.P328L	KMT2C_ENST00000262189.6_Missense_Mutation_p.P328L					lysine (K)-specific methyltransferase 2C																		AATGTGTTCTGGACAAAGCAG	0.378000													18	381					0	0	1	0	0
KRT85	3891	broad.mit.edu	37	12	52754805	52754805	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52754805G>A	ENST00000257901.3	-	9	1431	c.1356C>T	c.(1354-1356)gtC>gtT	p.V452V	KRT85_ENST00000544265.1_Silent_p.V240V	NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	452	Tail.				epidermis development	keratin filament	protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CCCCACAGGAGACTCCACCAC	0.652000													4	10					0	0	1	0	0
TRAJ36	28719	broad.mit.edu	37	14	22974135	22974135	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22974135G>A	ENST00000390501.1	+	0	40																											GGACTGGAACGAGACTCACCG	0.418000													23	55					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161152234	161152234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161152234C>T	ENST00000308192.9	+	11	1471	c.1408C>T	c.(1408-1410)Ctt>Ttt	p.L470F		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	470					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGTTGTCCTGCTTCCAGATGT	0.498000													11	54					0	0	1	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672818	141672818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141672818C>T	ENST00000547270.1	-	1	755	c.672G>A	c.(670-672)atG>atA	p.M224I		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	224					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					TCATTGTCCTCATGTGCCTTC	0.468000													24	62					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202702705	202702705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202702705G>A	ENST00000367265.3	-	23	4897	c.3733C>T	c.(3733-3735)Cgc>Tgc	p.R1245C	KDM5B_ENST00000367264.2_Missense_Mutation_p.R1281C	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1245					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding	p.R1245C(1)		breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TCAGGAAGGCGAACTCGGATA	0.512000													44	90					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192395	132192395	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:132192395G>A	ENST00000359827.3	-	2	2020	c.1058C>T	c.(1057-1059)tCg>tTg	p.S353L	PLXNA4_ENST00000423507.2_Missense_Mutation_p.S353L|PLXNA4_ENST00000321063.4_Missense_Mutation_p.S353L|PLXNA4_ENST00000378539.5_Missense_Mutation_p.S353L			Q9HCM2	PLXA4_HUMAN	plexin A4	353	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCACAGGGCCGACTCATCCAG	0.572000													19	72					0	0	1	0	0
CPNE9	151835	broad.mit.edu	37	3	9756994	9756994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9756994C>T	ENST00000383832.3	+	12	904	c.714C>T	c.(712-714)ttC>ttT	p.F238F	CPNE9_ENST00000383831.3_Silent_p.F238F	NM_153635.2	NP_705899.2	Q8IYJ1	CPNE9_HUMAN	copine family member IX	238	C2 2.									breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16	Medulloblastoma(99;0.227)					TTGGTGAGTTCACCACCAGCT	0.567000													14	71					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116285273	116285273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116285273G>A	ENST00000374140.2	+	18	2031	c.1822G>A	c.(1822-1824)Gac>Aac	p.D608N	RGS3_ENST00000374136.1_Missense_Mutation_p.D234N|RGS3_ENST00000350696.5_Missense_Mutation_p.D608N|RGS3_ENST00000394646.3_Missense_Mutation_p.D327N|RGS3_ENST00000343817.5_Missense_Mutation_p.D327N|RGS3_ENST00000317613.6_Missense_Mutation_p.D496N	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	608					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						TGGCCGCTGCGACGTCCTGAG	0.582000													12	118					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103698508	103698508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:103698508C>T	ENST00000245312.3	-	6	1618	c.1022G>A	c.(1021-1023)gGa>gAa	p.G341E		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	341					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TTGAAATCCTCCATTTGCCTT	0.363000													30	80					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	31062105	31062105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31062105C>T	ENST00000399914.1	-	3	1008	c.487G>A	c.(487-489)Gat>Aat	p.D163N	GRIK1_ENST00000399907.1_Missense_Mutation_p.D163N|GRIK1_ENST00000399913.1_Missense_Mutation_p.D163N|GRIK1_ENST00000389125.3_Missense_Mutation_p.D163N|GRIK1_ENST00000399909.1_Missense_Mutation_p.D163N|GRIK1_ENST00000327783.4_Missense_Mutation_p.D163N|GRIK1_ENST00000535441.1_Missense_Mutation_p.D163N|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000389124.2_Missense_Mutation_p.D163N|GRIK1_ENST00000309434.7_Missense_Mutation_p.D163N			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	163					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AGGACCAGATCCAGGATCGCC	0.488000													29	221					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69682029	69682029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69682029G>A	ENST00000265403.7	+	1	319	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	UGT2B10_ENST00000458688.2_Missense_Mutation_p.E98K	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	98					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						GAGATTGTCAGAAATTCAAAA	0.313000													37	94					0	0	1	0	0
IL12B	3593	broad.mit.edu	37	5	158747383	158747383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:158747383C>T	ENST00000231228.2	-	5	1083	c.628G>A	c.(628-630)Gtc>Atc	p.V210I		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	210					cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCACCATGACCTCAATGGGC	0.502000													11	136					0	0	1	0	0
RECK	8434	broad.mit.edu	37	9	36122898	36122898	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:36122898C>T	ENST00000377966.3	+	21	3338	c.2772C>T	c.(2770-2772)gtC>gtT	p.V924V		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	924						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CGTCCCATGTCCCTCTCTCTG	0.557000													35	126					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50683749	50683749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:50683749C>T	ENST00000442544.2	+	8	1901	c.1285C>T	c.(1285-1287)Cct>Tct	p.P429S	DCC_ENST00000580146.1_3'UTR|DCC_ENST00000581580.1_Missense_Mutation_p.P84S|DCC_ENST00000412726.1_Missense_Mutation_p.P277S	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	429	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CAGTGTCCTCCCTTCGGCTCC	0.537000													82	180					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99655718	99655718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:99655718C>T	ENST00000370597.3	-	10	1596	c.1241G>A	c.(1240-1242)gGa>gAa	p.G414E	CRTAC1_ENST00000298819.4_Missense_Mutation_p.G414E|CRTAC1_ENST00000370591.2_Missense_Mutation_p.G414E	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	414						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CATCCCGTCTCCGTCGAAGTC	0.582000													6	68					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717466	222717466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:222717466G>A	ENST00000343410.6	-	2	445	c.387C>T	c.(385-387)ctC>ctT	p.L129L		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	129					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		AGAGGCCCGGGAGATTCCGGA	0.577000													65	158					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152554067	152554067	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152554067G>A	ENST00000427231.2	-	14	1450	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F	NEB_ENST00000604864.1_Silent_p.F416F|NEB_ENST00000603639.1_Silent_p.F416F|NEB_ENST00000172853.10_Silent_p.F416F|NEB_ENST00000397345.3_Silent_p.F416F|NEB_ENST00000409198.1_Silent_p.F416F	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	416					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATCACTACTGAAGTTCTGCA	0.343000													9	97					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24491771	24491771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:24491771G>A	ENST00000264463.4	-	11	2297	c.1790C>T	c.(1789-1791)tCc>tTc	p.S597F	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	597	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCACTGCAGGATTGCATGTT	0.527000										HNSCC(23;0.051)			34	83					0	0	1	0	0
TNFSF4	7292	broad.mit.edu	37	1	173176258	173176258	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173176258C>T	ENST00000281834.3	-	1	194	c.58G>A	c.(58-60)Gag>Aag	p.E20K		NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	20					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						TTGTTCCTCTCGAATCTTGGC	0.512000													23	70					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189996	124189996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124189996C>T	ENST00000357438.2	-	1	188	c.98G>A	c.(97-99)gGa>gAa	p.G33E		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		CACATATATTCCAAGGAACAG	0.463000													33	113					0	0	1	0	0
LCN1	3933	broad.mit.edu	37	9	138415807	138415807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138415807G>A	ENST00000263598.2	+	4	434	c.374G>A	c.(373-375)gGg>gAg	p.G125E	LCN1_ENST00000371781.3_Missense_Mutation_p.G125E	NM_001252617.1|NM_001252618.1|NM_001252619.1|NM_002297.3	NP_001239546.1|NP_001239547.1|NP_001239548.1|NP_002288.1	P31025	LCN1_HUMAN	lipocalin 1	125					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)	13		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		GAGCTGCACGGGAAGCCGGTC	0.637000													11	41					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10603749	10603749	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:10603749C>T	ENST00000334534.5	+	8	1129	c.949C>T	c.(949-951)Cga>Tga	p.R317*		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		TGGAAGTGATCGATTAGTCCC	0.458000													33	125					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242139	60242139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:60242139C>T	ENST00000269499.5	+	13	3243	c.2825C>T	c.(2824-2826)tCt>tTt	p.S942F	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.S621F	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	942					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						GCAGCAACTTCTCCCCAGCCA	0.652000													8	106					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37506753	37506753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37506753G>A	ENST00000374660.1	+	39	3502	c.3403G>A	c.(3403-3405)Gct>Act	p.A1135T	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.A1016T|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.A1016T			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1110						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ACTTGAACAGGCTCTCAGAAT	0.289000													11	54					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98460836	98460836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98460836G>A	ENST00000450876.1	-	2	1336	c.21C>T	c.(19-21)tcC>tcT	p.S7S	TMEM130_ENST00000345589.4_Intron|TMEM130_ENST00000416379.2_Silent_p.S91S|TMEM130_ENST00000546258.1_Silent_p.S72S|TMEM130_ENST00000339375.4_Silent_p.S91S			Q8N3G9	TM130_HUMAN	transmembrane protein 130	91						Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CACGGATGGTGGAGCTGAGAC	0.657000													8	63					0	0	1	0	0
NT5C3B	115024	broad.mit.edu	37	17	39985108	39985108	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39985108G>A	ENST00000269534.8	-	7	578	c.477C>T	c.(475-477)atC>atT	p.I159I	NT5C3B_ENST00000435506.2_Silent_p.I167I|NT5C3B_ENST00000521789.1_Silent_p.I134I	NM_052935.4	NP_443167.4			5'-nucleotidase, cytosolic IIIB																		TCATCTGTCGGATAATTTCTT	0.438000													34	59					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233353659	233353659	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233353659C>A	ENST00000258229.8	-	12	2911	c.2677G>T	c.(2677-2679)Gcc>Tcc	p.A893S	PCNXL2_ENST00000430153.1_Missense_Mutation_p.A192S|PCNXL2_ENST00000488780.2_Missense_Mutation_p.A26S	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	893						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				ATTGGTGAGGCGGGGTCAGGC	0.433000													5	34					8.12818e-05	8.14046e-05	1	1	0
ENKUR	219670	broad.mit.edu	37	10	25273727	25273727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25273727C>T	ENST00000331161.4	-	5	921	c.702G>A	c.(700-702)atG>atA	p.M234I	ENKUR_ENST00000376363.1_Missense_Mutation_p.M234I	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	234						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						CTAGTTGTTTCATTTCTTCTT	0.348000													6	79					0	0	1	0	0
KCNN4	3783	broad.mit.edu	37	19	44278350	44278350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44278350G>A	ENST00000262888.3	-	3	1072	c.677C>T	c.(676-678)gCc>gTc	p.A226V		NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	226					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	TCACCTCTCGGCCACGGACAG	0.677000											OREG0025535	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	17					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31540583	31540583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31540583C>T	ENST00000454783.1	+	2	322	c.64C>T	c.(64-66)Ctg>Ttg	p.L22L	LTA_ENST00000418386.2_Silent_p.L22L	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	22					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	CCTCCTCCTTCTGGGGCTGCT	0.622000													24	78					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55761363	55761363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55761363C>T	ENST00000278409.1	-	1	738	c.739G>A	c.(739-741)Gcc>Acc	p.A247T		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A247S(1)		endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					AGAATTATGGCTGTCAGGTGA	0.493000													12	81					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36570342	36570342	+	Silent	SNP	G	G	A	rs144959929	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36570342G>A	ENST00000273183.3	+	10	1275	c.975G>A	c.(973-975)ggG>ggA	p.G325G	STAC_ENST00000457375.2_Silent_p.G264G	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	325	SH3.				intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						CCTTTCAGGGGAAAATTCAAG	0.338000													13	28					0	0	1	0	0
RBFA	79863	broad.mit.edu	37	18	77797462	77797462	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:77797462G>A	ENST00000306735.5	+	3	472	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	RBFA_ENST00000262197.7_Missense_Mutation_p.E112K|RBFADN_ENST00000569722.1_Intron|RBFA_ENST00000586847.1_3'UTR	NM_024805.2	NP_079081.2	Q8N0V3	RBFA_HUMAN	ribosome binding factor A (putative)	112					rRNA processing	mitochondrion				endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|urinary_tract(1)	15						GTGTACCCCTGAAGTGAGTCA	0.552000													63	125					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77386640	77386640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77386640C>T	ENST00000451710.3	-	25	3752	c.3515G>A	c.(3514-3516)cGa>cAa	p.R1172Q	TRPM6_ENST00000376864.4_Missense_Mutation_p.R1172Q|TRPM6_ENST00000361255.3_Missense_Mutation_p.R1167Q|TRPM6_ENST00000360774.1_Missense_Mutation_p.R1172Q|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Missense_Mutation_p.R1167Q			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1172					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CACTCGGATTCGTTCCTCACA	0.368000													7	79					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6305701	6305701	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6305701C>T	ENST00000264870.3	-	3	467	c.202G>A	c.(202-204)Gac>Aac	p.D68N		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	68					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TCATACTTGTCAGTGTGGTGG	0.453000													14	62					0	0	1	0	0
PDLIM5	10611	broad.mit.edu	37	4	95496819	95496819	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:95496819C>T	ENST00000317968.4	+	5	480	c.344C>T	c.(343-345)tCc>tTc	p.S115F	PDLIM5_ENST00000380180.3_Intron|PDLIM5_ENST00000450793.1_Intron|PDLIM5_ENST00000437932.1_Intron|PDLIM5_ENST00000514743.1_Intron|PDLIM5_ENST00000538141.1_Intron|PDLIM5_ENST00000542407.1_5'UTR|PDLIM5_ENST00000508216.1_Intron|PDLIM5_ENST00000318007.5_Intron	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	115					regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		CCTGCTGTGTCCAAAGTCACT	0.428000													52	139					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48419867	48419867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48419867C>T	ENST00000296438.5	+	6	652	c.466C>T	c.(466-468)Cct>Tct	p.P156S	FBXW12_ENST00000445170.1_Missense_Mutation_p.P137S|FBXW12_ENST00000436231.1_Intron|FBXW12_ENST00000415155.1_Intron	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	156										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGTAACCCTCCCTCAGATGCA	0.507000													6	56					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711529	192711529	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:192711529C>T	ENST00000304141.4	-	1	452	c.123G>A	c.(121-123)ggG>ggA	p.G41G	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	41						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CCTCTGTGTTCCCTAGGTTCA	0.607000													33	62					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25965265	25965265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:25965265G>A	ENST00000435504.4	-	13	4234	c.3941C>T	c.(3940-3942)cCg>cTg	p.P1314L	ASXL2_ENST00000336112.4_Missense_Mutation_p.P1286L|ASXL2_ENST00000404843.1_Missense_Mutation_p.P797L|ASXL2_ENST00000272341.4_Missense_Mutation_p.P797L			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	1314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATACAACTTCGGGGTTTGCAG	0.552000													6	9					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993181	28993181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28993181C>T	ENST00000359747.4	+	15	2832	c.2803C>T	c.(2803-2805)Cca>Tca	p.P935S	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.P916S|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	916					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TAATGCTGATCCATGTGTGCA	0.433000													68	144					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53662562	53662562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53662562C>T	ENST00000257934.4	+	2	103	c.12C>T	c.(10-12)ttC>ttT	p.F4F	ESPL1_ENST00000552462.1_Silent_p.F4F	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	4					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						TGAGGAGCTTCAAAAGAGTCA	0.532000													3	14					0	0	1	0	0
TMEM74	157753	broad.mit.edu	37	8	109797285	109797285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:109797285G>A	ENST00000297459.3	-	2	221	c.43C>T	c.(43-45)Ctc>Ttc	p.L15F	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	15					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			GCATCACAGAGGTCTGCCTGG	0.547000													14	53					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781494	128781494	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128781494G>A	ENST00000529694.1	+	2	702	c.326G>A	c.(325-327)tGg>tAg	p.W109*	KCNJ5_ENST00000338350.4_Nonsense_Mutation_p.W109*|KCNJ5_ENST00000533599.1_Nonsense_Mutation_p.W109*	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	109					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TTCATTTGGTGGCTCATTGCT	0.527000													32	71					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045064	87045064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87045064C>T	ENST00000370563.3	+	13	2192	c.2150C>T	c.(2149-2151)cCt>cTt	p.P717L	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	717						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CCGCCAAGACCTGAAATTGAT	0.438000													32	67					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800537	21800537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21800537C>T	ENST00000443632.2	+	2	1725	c.1353C>T	c.(1351-1353)ttC>ttT	p.F451F	HIC2_ENST00000407598.2_Silent_p.F451F|HIC2_ENST00000407464.2_Silent_p.F451F			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	451					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				CCAAGGGCTTCCCCAGCTCTG	0.622000													47	96					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1421334	1421334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:1421334G>A	ENST00000381312.1	-	2	447	c.122C>T	c.(121-123)aCc>aTc	p.T41I		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	41					mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		AGCGAGGAAGGTTGACAATAT	0.433000													20	49					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17464325	17464325	+	Silent	SNP	C	C	T	rs61748766	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17464325C>T	ENST00000302539.4	-	10	1697	c.1572G>A	c.(1570-1572)acG>acA	p.T524T	ABCC8_ENST00000528202.1_5'UTR|ABCC8_ENST00000389817.3_Silent_p.T524T	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	524	ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TCCTGCGGGTCGTCTCCACCC	0.597000													20	58					0	0	1	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21743221	21743221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21743221G>A	ENST00000319481.3	-	28	2981	c.2775C>T	c.(2773-2775)ccC>ccT	p.P925P	OSBPL1A_ENST00000399443.3_Silent_p.P412P|OSBPL1A_ENST00000357041.4_Silent_p.P543P	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	925					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CTCCATTGTAGGGATTAGGAC	0.408000													25	65					0	0	1	0	0
FAM86B1	85002	broad.mit.edu	37	8	12044027	12044027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:12044027C>T	ENST00000448228.2	-	5	523	c.474G>A	c.(472-474)cgG>cgA	p.R158R	FAM86B1_ENST00000533513.1_3'UTR|FAM86B1_ENST00000321602.8_Intron|FAM86B1_ENST00000534520.1_Intron|FAM86B1_ENST00000533852.2_Silent_p.R192R	NM_001083537.1	NP_001077006.1	Q8N7N1	F86B1_HUMAN	family with sequence similarity 86, member B1	158										kidney(1)|prostate(1)|stomach(1)	3			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		GCTCGAGGACCCGGCTGTGAG	0.612000													12	44					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53630443	53630443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:53630443G>A	ENST00000342160.3	-	26	3219	c.2762C>T	c.(2761-2763)tCc>tTc	p.S921F	HUWE1_ENST00000262854.6_Missense_Mutation_p.S921F|HUWE1_ENST00000218328.8_Missense_Mutation_p.S921F			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	921					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTGGTTTACGGAGATGGAACG	0.418000													28	18					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158908993	158908993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158908993C>T	ENST00000368140.1	+	4	780	c.535C>T	c.(535-537)Ccc>Tcc	p.P179S	PYHIN1_ENST00000392254.2_Missense_Mutation_p.P179S|PYHIN1_ENST00000368138.3_Missense_Mutation_p.P170S|PYHIN1_ENST00000368135.4_Missense_Mutation_p.P179S|PYHIN1_ENST00000392252.3_Missense_Mutation_p.P170S	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	179					cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					TTCCCCACCTCCCCAGACCTC	0.522000													50	138					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9046410	9046410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9046410C>T	ENST00000397910.4	-	5	35424	c.35221G>A	c.(35221-35223)Gag>Aag	p.E11741K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11743	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCACCATCTCTGGTGCACCA	0.488000													35	95					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10440650	10440650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10440650C>T	ENST00000245503.5	-	16	2181	c.1797G>A	c.(1795-1797)aaG>aaA	p.K599K	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Silent_p.K599K|MYH2_ENST00000532183.1_Silent_p.K599K|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	599	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GGTCCTTGTTCTTCTCCAGCC	0.527000													69	91					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138985	126138985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:126138985C>T	ENST00000299308.3	+	9	2974	c.2966C>T	c.(2965-2967)tCc>tTc	p.S989F	TMEM132B_ENST00000535886.1_Missense_Mutation_p.S501F	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	989						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AATGGCAGTTCCCAGAAGACT	0.453000													15	22					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55569674	55569674	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55569674G>A	ENST00000294383.6	-	42	4899	c.4900C>T	c.(4900-4902)Cga>Tga	p.R1634*	USP24_ENST00000407756.1_Nonsense_Mutation_p.R1474*	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1634					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						GCTGCCAATCGGCTATTCGCT	0.343000													7	6					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55419298	55419298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55419298G>A	ENST00000312422.2	+	1	919	c.919G>A	c.(919-921)Gag>Aag	p.E307K		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				TGTTTTCTTGGAGGCTAAAGG	0.363000													58	163					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569269	179569269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179569269G>A	ENST00000589042.1	-	105	30154	c.29930C>T	c.(29929-29931)cCa>cTa	p.P9977L	TTN_ENST00000342992.6_Missense_Mutation_p.P8733L|TTN_ENST00000591111.1_Missense_Mutation_p.P9660L|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9660	Glu-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCGATGTGTGGACCACAAAC	0.373000													12	37					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875287	247875287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247875287G>A	ENST00000302084.2	-	1	818	c.771C>T	c.(769-771)ttC>ttT	p.F257F	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGACGTGAAGGAAAACTGTGG	0.527000													37	103					0	0	1	0	0
TESK1	7016	broad.mit.edu	37	9	35608894	35608894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35608894C>T	ENST00000336395.5	+	10	1286	c.1036C>T	c.(1036-1038)Ccc>Tcc	p.P346S	TESK1_ENST00000498522.1_3'UTR	NM_006285.2	NP_006276.2	Q15569	TESK1_HUMAN	testis-specific kinase 1	346					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	27			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGCCACGCTTCCCAGGCCAGA	0.582000													41	112					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52031002	52031002	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52031002C>T	ENST00000346477.3	-	6	1207	c.1140_splice	c.e6+1	p.R380_splice	SIGLEC6_ENST00000391797.3_Intron|SIGLEC6_ENST00000436458.1_Splice_Site_p.R344_splice|SIGLEC6_ENST00000474054.1_5'UTR|SIGLEC6_ENST00000359982.4_Intron|SIGLEC6_ENST00000343300.4_Intron|SIGLEC6_ENST00000425629.3_Splice_Site_p.R396_splice	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	396					cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GTCACTCACCCTGGAGCCTGA	0.488000													35	164					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327197	150327197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150327197C>T	ENST00000328902.5	-	2	250	c.34G>A	c.(34-36)Gag>Aag	p.E12K	GIMAP6_ENST00000493969.1_Missense_Mutation_p.E12K	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	12							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGGGATTCTCCTGGGGAATT	0.423000													53	136					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57417739	57417739	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57417739C>T	ENST00000543257.1	-	6	1058	c.492G>A	c.(490-492)gtG>gtA	p.V164V	C8B_ENST00000371237.4_Silent_p.V216V|C8B_ENST00000535057.1_Silent_p.V154V	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	216	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGTAGCTTTCCACATTGTAGG	0.552000													48	97					0	0	1	0	0
SLC15A1	6564	broad.mit.edu	37	13	99378490	99378490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:99378490G>A	ENST00000376503.5	-	4	187	c.132C>T	c.(130-132)ttC>ttT	p.F44F		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	44					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CCCAGCTGATGAAATTTGTGA	0.522000													20	61					0	0	1	0	0
ST7	7982	broad.mit.edu	37	7	116862069	116862069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:116862069C>T	ENST00000265437.5	+	15	1805	c.1591C>T	c.(1591-1593)Ctc>Ttc	p.L531F	ST7_ENST00000393451.3_Missense_Mutation_p.L508F|ST7_ENST00000393443.1_Missense_Mutation_p.L453F|ST7_ENST00000393446.2_Missense_Mutation_p.L477F|ST7_ENST00000432298.1_Missense_Mutation_p.L485F|ST7_ENST00000422922.1_Missense_Mutation_p.L462F|ST7_ENST00000393444.3_Missense_Mutation_p.L465F|ST7_ENST00000323984.3_Missense_Mutation_p.L531F|ST7_ENST00000393449.1_Missense_Mutation_p.L526F|ST7_ENST00000393447.4_Missense_Mutation_p.L488F	NM_021908.2	NP_068708.1	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7	531						integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(1)	21	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CATGCTGGCCCTCCTGACACA	0.507000													27	92					0	0	1	0	0
DMRTC2	63946	broad.mit.edu	37	19	42354563	42354563	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42354563C>T	ENST00000596827.1	+	7	1025	c.939C>T	c.(937-939)ttC>ttT	p.F313F	DMRTC2_ENST00000269945.3_Intron			Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	275	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						AGCGGGGGTTCCCAGTCTGCT	0.617000													24	79					0	0	1	0	0
KISS1	3814	broad.mit.edu	37	1	204159666	204159666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204159666G>A	ENST00000367194.4	-	3	511	c.363C>T	c.(361-363)ttC>ttT	p.F121F		NM_002256.3	NP_002247.3	Q15726	KISS1_HUMAN	KiSS-1 metastasis-suppressor	121	Essential for receptor binding and receptor activation.				cytoskeleton organization	extracellular region	protein binding			large_intestine(1)|lung(1)|ovary(1)	3	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)	Breast(1374;9.42e-05)	KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.069)|Kidney(21;0.0934)|Epithelial(59;0.239)	Colorectal(1306;0.0129)		CCCGCTTGCCGAAGCGCAGGC	0.692000													9	8					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27660021	27660021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27660021C>T	ENST00000261588.4	+	6	524	c.505C>T	c.(505-507)Ctc>Ttc	p.L169F	KIAA0556_ENST00000567894.1_3'UTR	NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	169										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GGATGTGACTCTCCAGGCAAA	0.562000													10	42					0	0	1	0	0
GPR55	9290	broad.mit.edu	37	2	231775413	231775413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231775413G>A	ENST00000392040.1	-	2	457	c.265C>T	c.(265-267)Ccc>Tcc	p.P89S	GPR55_ENST00000392039.2_Missense_Mutation_p.P89S	NM_005683.3	NP_005674.2	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	89					activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			endometrium(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		GACGGGAAGGGGGACTGTACC	0.557000													24	56					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143747606	143747606	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143747606C>T	ENST00000408906.2	+	1	146	c.112C>T	c.(112-114)Ctg>Ttg	p.L38L		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CGTCTTCACCCTGCTGGGAAA	0.512000													53	100					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101609053	101609053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101609053C>T	ENST00000311812.2	-	10	942	c.792G>A	c.(790-792)cgG>cgA	p.R264R	SNX31_ENST00000428383.2_Silent_p.R165R	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	264					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			GCCGTACCTCCCGGGCCAGCT	0.512000													31	83					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3511920	3511920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3511920C>T	ENST00000356575.4	-	3	584	c.358G>A	c.(358-360)Gag>Aag	p.E120K		NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	120	EMI.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CAGCCCTCCTCGTCGGGCTGC	0.662000													21	57					0	0	1	0	0
PRSS35	167681	broad.mit.edu	37	6	84233940	84233940	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:84233940G>A	ENST00000536636.1	+	3	1125	c.780G>A	c.(778-780)ccG>ccA	p.P260P	PRSS35_ENST00000369700.3_Silent_p.P260P	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	260	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		CCCACATTCCGAAGGGCTGGG	0.537000													4	28					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73826224	73826224	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73826224C>T	ENST00000207549.4	-	30	3218	c.2839G>A	c.(2839-2841)Gac>Aac	p.D947N	UNC13D_ENST00000412096.2_Missense_Mutation_p.D947N	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	947	C2 2.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACAAAGGGGTCGCTGGAGCCT	0.637000									Familial Hemophagocytic Lymphohistiocytosis		OREG0024741	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	8					0	0	1	0	0
DDX55	57696	broad.mit.edu	37	12	124094582	124094582	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124094582C>T	ENST00000238146.4	+	7	698	c.648C>T	c.(646-648)ggC>ggT	p.G216G	DDX55_ENST00000538744.1_Silent_p.G216G	NM_020936.1	NP_065987.1	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	216	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TGAGAGCGGGCCTCCGGAACC	0.577000													24	52					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24433686	24433686	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24433686C>T	ENST00000330966.7	-	4	444	c.282G>A	c.(280-282)gaG>gaA	p.E94E	MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Silent_p.E93E|MYOM3_ENST00000374434.3_Silent_p.E93E			Q5VTT5	MYOM3_HUMAN	myomesin 3	93										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCTCCTCCAGCTCCACGGCAG	0.687000													4	14					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158257668	158257668	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:158257668T>A	ENST00000296526.7	+	11	1938	c.1613T>A	c.(1612-1614)tTt>tAt	p.F538Y	GRIA2_ENST00000507898.1_Missense_Mutation_p.F491Y|GRIA2_ENST00000449365.1_Missense_Mutation_p.F491Y|GRIA2_ENST00000264426.9_Missense_Mutation_p.F538Y|GRIA2_ENST00000393815.2_Missense_Mutation_p.F491Y	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	538					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GTGTTTTCCTTTCTTGATCCT	0.448000													86	232					0	0	1	0	0
TMCO4	255104	broad.mit.edu	37	1	20107104	20107104	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20107104G>A	ENST00000294543.6	-	4	389	c.148C>T	c.(148-150)Ctg>Ttg	p.L50L	TMCO4_ENST00000375122.2_Silent_p.L50L|TMCO4_ENST00000375127.1_Silent_p.L50L	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	50						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AACTGGGACAGGGAGATGCCA	0.592000													11	37					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17294426	17294426	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:17294426C>T	ENST00000261381.6	-	4	1083	c.999G>A	c.(997-999)gtG>gtA	p.V333V		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	333					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGCCGTGGACCACCAGGACAA	0.562000													59	146					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120512162	120512162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120512162G>A	ENST00000256646.2	-	6	1299	c.1080C>T	c.(1078-1080)ttC>ttT	p.F360F		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	360	EGF-like 9; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACATGCAAGAGAAGGAGGCCA	0.562000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				4	37					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239016599	239016599	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239016599G>A	ENST00000343063.3	+	4	1103	c.840G>A	c.(838-840)gaG>gaA	p.E280E	ESPNL_ENST00000409169.1_Silent_p.E280E	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	280										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		ACGCAGCAGAGAACGGGCAGA	0.642000													9	32					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150693611	150693611	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150693611C>T	ENST00000297494.3	+	4	747	c.390C>T	c.(388-390)ttC>ttT	p.F130F	NOS3_ENST00000467517.1_Silent_p.F130F|NOS3_ENST00000484524.1_Silent_p.F130F|NOS3_ENST00000461406.1_Intron	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	130	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCCGGGACTTCATCAACCAGT	0.652000													13	23					0	0	1	0	0
RP11-85G18.6	0	broad.mit.edu	37	10	27535148	27535148	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27535148C>T	ENST00000574842.1	+	0	255																											GTTATTTACTCTTGTGGCACT	0.473000													15	23					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49825033	49825033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:49825033C>T	ENST00000451037.2	-	4	1365	c.425G>A	c.(424-426)gGg>gAg	p.G142E	CA10_ENST00000442502.2_Missense_Mutation_p.G142E|CA10_ENST00000340813.6_Missense_Mutation_p.G148E|CA10_ENST00000570565.1_Missense_Mutation_p.G67E|CA10_ENST00000285273.4_Missense_Mutation_p.G142E|CA10_ENST00000571918.1_5'UTR	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	142					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTGCTCCGACCCTTGGCTGTC	0.512000													57	131					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124358351	124358351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124358351G>A	ENST00000338354.3	+	26	3124	c.3018G>A	c.(3016-3018)gtG>gtA	p.V1006V	DMBT1_ENST00000344338.3_Silent_p.V996V|DMBT1_ENST00000368955.3_Silent_p.V996V|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Silent_p.V507V|DMBT1_ENST00000368956.2_Silent_p.V507V|DMBT1_ENST00000368909.3_Silent_p.V1006V			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1006	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AGGGCCGAGTGGAGGTCCTAT	0.572000													141	450					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58118247	58118247	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58118247C>T	ENST00000332854.6	+	3	1574	c.1354C>T	c.(1354-1356)Cga>Tga	p.R452*	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGGCCTCTTTCGACACAGAAG	0.423000													37	126					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58074568	58074568	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58074568C>T	ENST00000219271.3	+	5	1661	c.876C>T	c.(874-876)ccC>ccT	p.P292P		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	292					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						TCAAGCTGCCCGAGGACGATC	0.627000													28	63					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106960963	106960963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106960963G>A	ENST00000369701.3	+	16	2440	c.2213G>A	c.(2212-2214)gGa>gAa	p.G738E	SORCS3_ENST00000369699.4_Missense_Mutation_p.G24E	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	738						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GACCACTCAGGATCAGTGGTC	0.493000													22	103					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367424	234367424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:234367424C>T	ENST00000366618.3	+	3	690	c.545C>T	c.(544-546)cCg>cTg	p.P182L	SLC35F3_ENST00000366617.3_Missense_Mutation_p.P113L	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	113					transport	integral to membrane		p.P182Q(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TTATTCTTCCCGTTGTACTAC	0.592000													10	195					0	0	1	0	0
TTTY11	83866	broad.mit.edu	37	Y	8657192	8657192	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:8657192C>T	ENST00000253470.4	-	0	272					NR_001548.2																						TGCCAATGTTCTCATGACCAC	0.433000													10	13					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125877456	125877456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125877456G>A	ENST00000393434.2	-	3	503	c.154C>T	c.(154-156)Ccg>Tcg	p.P52S	ALDH1L1_ENST00000393431.2_Missense_Mutation_p.P52S|ALDH1L1_ENST00000472186.1_Missense_Mutation_p.P52S|ALDH1L1_ENST00000452905.2_Missense_Mutation_p.P52S|ALDH1L1_ENST00000273450.3_Missense_Mutation_p.P62S|ALDH1L1_ENST00000455064.2_Intron	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	52	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TTGAATACCGGCACTCCATCC	0.582000													19	107					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140221126	140221126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140221126C>T	ENST00000531613.1	+	1	220	c.220C>T	c.(220-222)Ctt>Ttt	p.L74F	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.L74F|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACCGGGACCTTCTGGAGGT	0.642000													24	220					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31215756	31215756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31215756C>T	ENST00000349752.5	-	2	886	c.247G>A	c.(247-249)Gag>Aag	p.E83K	GALNT14_ENST00000406653.1_Missense_Mutation_p.E63K|GALNT14_ENST00000356174.3_Missense_Mutation_p.E83K|GALNT14_ENST00000324589.5_Intron|GALNT14_ENST00000420311.2_Missense_Mutation_p.E48K	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	83						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					CGCTCACTCTCCCGCTGGTTG	0.562000													31	73					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152060506	152060506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152060506C>T	ENST00000368806.1	-	2	178	c.114G>A	c.(112-114)caG>caA	p.Q38Q		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	38							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CAAACTCGCCCTGGATGAGTT	0.443000													50	194					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126371800	126371800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126371800G>A	ENST00000394329.3	+	9	9642	c.9629G>A	c.(9628-9630)gGa>gAa	p.G3210E	FAT4_ENST00000335110.5_Missense_Mutation_p.G1508E	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3210	Cadherin 31.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCCCCAAGTGGAACAACAGTT	0.408000													44	89					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120906771	120906771	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120906771C>T	ENST00000310396.5	+	20	3009	c.2542C>T	c.(2542-2544)Cta>Tta	p.L848L		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		ATCACGTCCCCTAGAGAATAC	0.403000													29	97					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14564608	14564608	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14564608G>A	ENST00000273083.3	-	0	556							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CAAGAAGCAGGAATCATCCAC	0.587000													22	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179466465	179466465	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179466465C>T	ENST00000589042.1	-	286	55576	c.55352G>A	c.(55351-55353)cGa>cAa	p.R18451Q	TTN_ENST00000342992.6_Missense_Mutation_p.R15883Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R16810Q|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R9578Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R9511Q|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R9386Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16810	Ig-like 106.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTATGAGATCGTTTACACTC	0.363000													23	80					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123513287	123513287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123513287G>A	ENST00000392770.2	-	3	1114	c.312C>T	c.(310-312)tcC>tcT	p.S104S	SCN3B_ENST00000530277.1_Silent_p.S104S|SCN3B_ENST00000299333.3_Silent_p.S104S	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	104	Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		GCACAGTGATGGACACGTCCT	0.567000													23	65					0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24845205	24845205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24845205G>A	ENST00000413692.2	+	9	2287	c.2143G>A	c.(2143-2145)Gag>Aag	p.E715K	NFATC4_ENST00000554473.1_Missense_Mutation_p.E187K|NFATC4_ENST00000555802.1_5'UTR|NFATC4_ENST00000555167.1_Missense_Mutation_p.E187K|NFATC4_ENST00000556169.1_Missense_Mutation_p.E640K|NFATC4_ENST00000557767.1_5'UTR|NFATC4_ENST00000556279.1_Missense_Mutation_p.E684K|NFATC4_ENST00000556759.1_Missense_Mutation_p.E187K|NFATC4_ENST00000554591.1_Missense_Mutation_p.E715K|NFATC4_ENST00000555453.1_Missense_Mutation_p.E640K|NFATC4_ENST00000555393.1_5'UTR|NFATC4_ENST00000422617.3_Missense_Mutation_p.E640K|NFATC4_ENST00000554661.1_Missense_Mutation_p.E582K|NFATC4_ENST00000424781.2_Missense_Mutation_p.E665K|NFATC4_ENST00000553879.1_Missense_Mutation_p.E582K|NFATC4_ENST00000554050.1_Missense_Mutation_p.E652K|NFATC4_ENST00000554966.1_Missense_Mutation_p.E665K|NFATC4_ENST00000553708.1_Missense_Mutation_p.E652K|NFATC4_ENST00000539237.2_Missense_Mutation_p.E684K|NFATC4_ENST00000250373.4_Missense_Mutation_p.E652K|NFATC4_ENST00000553469.1_Missense_Mutation_p.E684K|NFATC4_ENST00000555590.1_Missense_Mutation_p.E665K|NFATC4_ENST00000554344.1_Missense_Mutation_p.E582K|NFATC4_ENST00000557451.1_Missense_Mutation_p.E582K	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	652					cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		GACTGTCCCCGAGTACAGCAA	0.577000													24	221					0	0	1	0	0
PGM5P2	595135	broad.mit.edu	37	9	69113627	69113627	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:69113627C>T	ENST00000591037.1	-	0	1018					NR_002836.2																						CCATATTCTCCTCCTTTCATT	0.458000													6	60					0	0	1	0	0
NECAB2	54550	broad.mit.edu	37	16	84024221	84024221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84024221G>A	ENST00000565691.1	+	4	1055	c.333G>A	c.(331-333)caG>caA	p.Q111Q	NECAB2_ENST00000305202.4_Silent_p.Q194Q			Q7Z6G3	NECA2_HUMAN	N-terminal EF-hand calcium binding protein 2	194	EF-hand 2.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding	p.Q194Q(1)		endometrium(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19						TCGAGGAACAGACCAGCCAGC	0.627000													20	42					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113532972	113532972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113532972C>T	ENST00000257600.3	+	7	2015	c.1512C>T	c.(1510-1512)acC>acT	p.T504T	DTX1_ENST00000547974.1_3'UTR	NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	504					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						ATACCCAGACCATCCGCATCG	0.642000													7	102					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56417688	56417688	+	Missense_Mutation	SNP	G	G	A	rs112177059		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56417688G>A	ENST00000370754.5	-	61	15808	c.15809C>T	c.(15808-15810)tCg>tTg	p.S5270L	DST_ENST00000370788.2_Missense_Mutation_p.S3004L|DST_ENST00000361203.3_Missense_Mutation_p.S5090L|DST_ENST00000421834.2_Missense_Mutation_p.S3004L|DST_ENST00000446842.2_Missense_Mutation_p.S4766L|DST_ENST00000370769.4_Missense_Mutation_p.S5092L|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.S2678L			Q03001	DYST_HUMAN	dystonin	5090					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity	p.S5092L(1)		NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GGATCCCAGCGAATCATGGAT	0.418000													39	217					0	0	1	0	0
NNMT	4837	broad.mit.edu	37	11	114168706	114168706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:114168706G>A	ENST00000535401.1	+	4	452	c.188G>A	c.(187-189)gGc>gAc	p.G63D	NNMT_ENST00000541754.1_5'UTR|NNMT_ENST00000299964.3_Missense_Mutation_p.G63D|RP11-64D24.2_ENST00000544925.1_RNA			P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	63	S-adenosyl-L-methionine binding.				xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	ATTGACATCGGCTCTGGCCCC	0.512000													45	85					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131027	72131027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72131027G>A	ENST00000265381.4	-	2	1322	c.1100C>T	c.(1099-1101)tCg>tTg	p.S367L		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	367					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GGTGTAAGGCGAACGGATGGT	0.617000													29	78					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34078170	34078170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34078170G>A	ENST00000389232.4	+	66	9646	c.9576G>A	c.(9574-9576)atG>atA	p.M3192I	RYR3_ENST00000415757.3_Missense_Mutation_p.M3192I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3192					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTCCTGGATGAAGCGCATTG	0.498000													60	160					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81568677	81568677	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81568677G>A	ENST00000548058.1	+	8	2119	c.1209G>A	c.(1207-1209)caG>caA	p.Q403Q	ACSS3_ENST00000548324.1_Silent_p.Q85Q|ACSS3_ENST00000261206.3_Silent_p.Q402Q			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	403						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TCCGTCAACAGGACCCTGGGG	0.493000													13	59					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18554486	18554486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18554486G>A	ENST00000251296.1	+	2	548	c.165G>A	c.(163-165)cgG>cgA	p.R55R		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	55	Ig-like 1.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		GGCGCATGCGGGAGATCGTGT	0.582000													35	66					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73558989	73558989	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73558989C>T	ENST00000224721.6	+	50	7196	c.7191C>T	c.(7189-7191)atC>atT	p.I2397I	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Silent_p.I152I	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2392	Cadherin 22.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding	p.I2397I(1)		NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACCTGGAAATCGTGGACATCA	0.617000													7	49					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34018827	34018827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:34018827G>A	ENST00000382499.2	-	24	3239	c.3240C>T	c.(3238-3240)tcC>tcT	p.S1080S	SYNJ1_ENST00000357345.3_Silent_p.S1041S|SYNJ1_ENST00000382491.3_Silent_p.S1036S|SYNJ1_ENST00000322229.7_Silent_p.S1041S|SYNJ1_ENST00000433931.2_Silent_p.S1080S	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1041	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						AAGAGCTGGGGGAAGTACCAA	0.522000													6	106					0	0	1	0	0
RRP15	51018	broad.mit.edu	37	1	218458698	218458698	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:218458698G>A	ENST00000366932.3	+	1	70	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	RRP15_ENST00000491428.1_3'UTR	NM_016052.3	NP_057136.2	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog (S. cerevisiae)	14						mitochondrion|nucleolus	protein binding		ACBD6/RRP15(2)	NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		GAGTGAGGAAGAAAACCTGAA	0.547000													22	59					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64526872	64526872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64526872C>T	ENST00000498707.1	-	36	5762	c.5420G>A	c.(5419-5421)gGg>gAg	p.G1807E	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.G1779E	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1807	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GCGCCGGCTCCCGTTATAGGG	0.478000													46	103					0	0	1	0	0
NIPA1	123606	broad.mit.edu	37	15	23049282	23049282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23049282G>A	ENST00000437912.2	-	5	1609	c.312C>T	c.(310-312)atC>atT	p.I104I	NIPA1_ENST00000561183.1_Silent_p.I104I|NIPA1_ENST00000538684.1_Silent_p.I9I|NIPA1_ENST00000337435.4_Silent_p.I179I			Q7RTP0	NIPA1_HUMAN	non imprinted in Prader-Willi/Angelman syndrome 1	179					cell death	early endosome|integral to membrane|plasma membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|skin(1)	15		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		GGGCCGGCGCGATCCAGAAGA	0.607000													5	23					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15326904	15326904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:15326904G>A	ENST00000281513.5	-	50	6698	c.6673C>T	c.(6673-6675)Cgc>Tgc	p.R2225C	NBAS_ENST00000441750.1_Missense_Mutation_p.R2105C	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	2225										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TACAAAGAGCGACACATTTTC	0.428000													39	112					0	0	1	0	0
C14orf166	51637	broad.mit.edu	37	14	52460467	52460467	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52460467C>T	ENST00000261700.3	+	3	378	c.213C>T	c.(211-213)ttC>ttT	p.F71F	C14orf166_ENST00000556760.1_Silent_p.F71F	NM_016039.2	NP_057123.1	Q9Y224	CN166_HUMAN	chromosome 14 open reading frame 166	71						microtubule organizing center|nucleus|perinuclear region of cytoplasm|tRNA-splicing ligase complex	identical protein binding			endometrium(1)|large_intestine(3)|lung(2)	6	Breast(41;0.0639)|all_epithelial(31;0.101)					ACTGTCCTTTCAAGATTCAAG	0.373000													20	62					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75509332	75509332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75509332C>T	ENST00000228027.7	+	7	1130	c.870C>T	c.(868-870)ttC>ttT	p.F290F	DGAT2_ENST00000376262.3_Silent_p.F247F	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	290					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					AGGTGATCTTCGAGGAGGGCT	0.537000													69	159					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126136884	126136884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126136884G>A	ENST00000373631.3	+	11	3417	c.3416G>A	c.(3415-3417)aGc>aAc	p.S1139N	CRB2_ENST00000373629.2_Missense_Mutation_p.S807N	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	1139	EGF-like 14.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						AAGGAGTGCAGCCTGAATGTC	0.662000													5	56					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95847020	95847020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95847020C>T	ENST00000398107.2	+	4	843	c.321C>T	c.(319-321)tcC>tcT	p.S107S	ZNF2_ENST00000340539.5_Silent_p.S149S|ZNF2_ENST00000295210.6_Silent_p.S111S|ZNF2_ENST00000453539.2_Silent_p.S162S|ZNF2_ENST00000425369.1_Silent_p.S69S	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		GTAAGAAATCCCTCTCCCGGG	0.522000													26	78					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79440623	79440623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79440623C>T	ENST00000264895.6	+	67	10968	c.10528C>T	c.(10528-10530)Ctc>Ttc	p.L3510F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3505					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGACACTGTTCTCTGGAGAAC	0.473000													90	167					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133911710	133911710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133911710G>A	ENST00000361069.4	+	4	1100	c.967G>A	c.(967-969)Gag>Aag	p.E323K	LAMC3_ENST00000480883.1_3'UTR	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	323	Laminin EGF-like 1.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GGCTGCCCACGAGTGTCTGCG	0.677000													14	43					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99489896	99489896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99489896C>T	ENST00000355947.2	-	7	1522	c.1393G>A	c.(1393-1395)Gga>Aga	p.G465R	TRIM4_ENST00000349062.2_Missense_Mutation_p.G439R	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	465	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				AGGTGCACTCCGTCCACAGCG	0.537000													60	126					0	0	1	0	0
STS	412	broad.mit.edu	37	X	7171326	7171326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:7171326C>T	ENST00000217961.4	+	2	321	c.101C>T	c.(100-102)gCt>gTt	p.A34V		NM_000351.4	NP_000342.2	P08842	STS_HUMAN	steroid sulfatase (microsomal), isozyme S	34					female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(1)	27		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CTGGTGATGGCTGACGACCTC	0.502000									Ichthyosis				15	33					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127944915	127944915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:127944915G>A	ENST00000335247.7	-	8	1181	c.1051C>T	c.(1051-1053)Cat>Tat	p.H351Y	CYP27C1_ENST00000409327.1_Missense_Mutation_p.H351Y	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	351						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		GTTTTTGCATGAACAGCATTG	0.453000													34	71					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6472692	6472692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6472692G>A	ENST00000358945.3	-	2	1041	c.601C>T	c.(601-603)Cgt>Tgt	p.R201C	SCNN1A_ENST00000540037.1_5'UTR|SCNN1A_ENST00000396966.2_Missense_Mutation_p.R201C|SCNN1A_ENST00000360168.3_Missense_Mutation_p.R260C|SCNN1A_ENST00000228916.2_Missense_Mutation_p.R201C|SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000543768.1_Missense_Mutation_p.R224C			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	201					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	CGGGCTCGACGGGCCCCGTGA	0.726000													12	21					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16032908	16032908	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16032908C>T	ENST00000326742.7	-	8	1055	c.1054G>A	c.(1054-1056)Gaa>Aaa	p.E352K	CYP4F11_ENST00000402119.3_Missense_Mutation_p.E352K|CYP4F11_ENST00000248041.7_Missense_Mutation_p.E352K			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	352					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						CGGCACTGTTCCTGGTATTCT	0.522000													30	52					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097327	167097327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167097327G>A	ENST00000361200.2	+	6	3125	c.2959G>A	c.(2959-2961)Gaa>Aaa	p.E987K	DUSP27_ENST00000443333.1_Missense_Mutation_p.E987K|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.E987K			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	987	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCAGTCAGAGGAACAGGACAC	0.517000													8	122					0	0	1	0	0
PAPOLA	10914	broad.mit.edu	37	14	97002296	97002296	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:97002296C>T	ENST00000216277.8	+	11	1210	c.990C>T	c.(988-990)tcC>tcT	p.S330S	PAPOLA_ENST00000392990.2_Silent_p.S330S	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	330					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ACAATGTGTCCGTTTCAACAC	0.413000													37	74					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75609555	75609555	+	Silent	SNP	C	C	T	rs147867930		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75609555C>T	ENST00000294638.5	+	7	1300	c.636C>T	c.(634-636)gcC>gcT	p.A212A	LHX8_ENST00000356261.3_Silent_p.A202A	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	212						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						TGGAAGGTGCCCTCCTCACAG	0.393000													15	46					0	0	1	0	0
PROSER2	254427	broad.mit.edu	37	10	11911536	11911536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11911536C>T	ENST00000277570.5	+	4	593	c.439C>T	c.(439-441)Cct>Tct	p.P147S	PROSER2-AS1_ENST00000453242.1_RNA|PROSER2-AS1_ENST00000445498.1_RNA	NM_153256.3	NP_694988.3			proline and serine-rich protein 2																		TGCTGAGACTCCTCCACCTCC	0.667000													13	35					0	0	1	0	0
AARD	441376	broad.mit.edu	37	8	117954928	117954928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:117954928G>A	ENST00000378279.3	+	2	501	c.456G>A	c.(454-456)gcG>gcA	p.A152A	AARD_ENST00000523536.1_3'UTR	NM_001025357.2	NP_001020528.1	Q4LEZ3	AARD_HUMAN	alanine and arginine rich domain containing protein	152																	ATGATGCTGCGAATCCGGAAT	0.502000													19	67					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960618	73960618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73960618C>T	ENST00000373468.1	-	3	4425	c.3774G>A	c.(3772-3774)ttG>ttA	p.L1258L	KIAA2022_ENST00000055682.5_Silent_p.L1258L			Q5QGS0	K2022_HUMAN	KIAA2022	1258					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TACATTCAGCCAATGTCTTCC	0.507000													19	4					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105803263	105803263	+	Silent	SNP	G	G	A	rs148868816		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105803263G>A	ENST00000353479.5	-	35	2801	c.2511C>T	c.(2509-2511)gcC>gcT	p.A837A	COL17A1_ENST00000369733.3_Silent_p.A837A	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	837	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ACTGACCTGGGGCACCTGGAG	0.557000													14	29					0	0	1	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629337	9629337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:9629337G>A	ENST00000382492.2	-	1	1126	c.808C>T	c.(808-810)Cct>Tct	p.P270S	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	270					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						TGTCCAGAAGGGTATATACCA	0.373000													34	96					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123285917	123285917	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123285917C>T	ENST00000253079.6	+	9	1568	c.1224C>T	c.(1222-1224)aaC>aaT	p.N408N	CCDC62_ENST00000392441.4_Silent_p.N408N|CCDC62_ENST00000392440.2_Silent_p.N169N|CCDC62_ENST00000537566.1_Silent_p.N169N	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	408						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		AGAAACACAACCTCCCTTGGT	0.413000													9	40					0	0	1	0	0
PABPC1L	80336	broad.mit.edu	37	20	43559289	43559289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43559289C>T	ENST00000255136.3	+	8	1243	c.1161C>T	c.(1159-1161)tcC>tcT	p.S387S	PABPC1L_ENST00000217074.4_3'UTR|PABPC1L_ENST00000217073.2_Silent_p.S387S|PABPC1L_ENST00000490798.1_3'UTR|PABPC1L_ENST00000537323.1_3'UTR	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like	387							nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						AGCGCCTCTCCACCATGCGGA	0.652000													42	231					0	0	1	0	0
ALDH3A1	218	broad.mit.edu	37	17	19642357	19642357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:19642357C>T	ENST00000457500.2	-	8	1497	c.1168G>A	c.(1168-1170)Gat>Aat	p.D390N	ALDH3A1_ENST00000225740.6_Missense_Mutation_p.D390N|ALDH3A1_ENST00000444455.1_Missense_Mutation_p.D390N|ALDH3A1_ENST00000395555.3_Missense_Mutation_p.D326N|ALDH3A1_ENST00000494157.2_Missense_Mutation_p.D317N	NM_001135168.1	NP_001128640.1	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3 family, member A1	390					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	ACGATGACATCGTTGGCCGCC	0.632000													18	13					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96533503	96533503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:96533503C>T	ENST00000389672.5	+	1	74	c.36C>T	c.(34-36)tcC>tcT	p.S12S	EPHA6_ENST00000470610.2_Silent_p.S12S	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	0						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CGAGGAGCTCCCCGGCGCCGC	0.711000													9	24					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125141072	125141072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125141072C>T	ENST00000362012.2	+	5	376	c.371C>T	c.(370-372)cCc>cTc	p.P124L	PTGS1_ENST00000223423.4_Missense_Mutation_p.P124L|PTGS1_ENST00000540753.1_Missense_Mutation_p.P99L|PTGS1_ENST00000373698.5_Missense_Mutation_p.P15L	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	124					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	AACCTTATCCCCAGTCCCCCC	0.537000													13	58					0	0	1	0	0
TAS2R4	50832	broad.mit.edu	37	7	141478552	141478552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141478552C>T	ENST00000247881.2	+	1	311	c.264C>T	c.(262-264)ttC>ttT	p.F88F	SSBP1_ENST00000465582.1_Intron	NM_016944.1	NP_058640.1	Q9NYW5	TA2R4_HUMAN	taste receptor, type 2, member 4	88					sensory perception of taste	cilium membrane	taste receptor activity			endometrium(1)|large_intestine(4)|lung(2)	7	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		TGTTGTGTTTCATGTTTTTGG	0.418000													44	144					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130287237	130287237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130287237G>A	ENST00000358511.6	+	5	2221	c.2190G>A	c.(2188-2190)acG>acA	p.T730T	COL6A6_ENST00000453409.2_Silent_p.T730T	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	730	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCCTCATCACGGATGGTGAAG	0.517000													14	83					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91795728	91795728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91795728C>T	ENST00000394232.1	+	4	1232	c.762C>T	c.(760-762)gcC>gcT	p.A254A	SV2B_ENST00000545111.2_Silent_p.A103A|SV2B_ENST00000330276.4_Silent_p.A254A	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	254					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CTGCCATGGCCTGGAGCATCA	0.542000													13	59					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31232216	31232216	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31232216G>A	ENST00000322122.3	+	5	1001		c.e5-1			NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72						exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						TCTCTCTCCAGAAATACTGCC	0.542000													36	103					0	0	1	0	0
DNAAF3	352909	broad.mit.edu	37	19	55672734	55672734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55672734G>A	ENST00000527223.2	-	7	921	c.920C>T	c.(919-921)gCc>gTc	p.A307V	CTD-2587H24.5_ENST00000591665.1_RNA|DNAAF3_ENST00000524407.2_Missense_Mutation_p.A239V|DNAAF3_ENST00000391720.4_Missense_Mutation_p.A286V|DNAAF3_ENST00000455045.1_Missense_Mutation_p.A185V	NM_001256714.1	NP_001243643.1	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	239																	GAGTTCAAAGGCGACGCCTGT	0.667000													8	15					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56083794	56083794	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56083794G>A	ENST00000429804.2	-	8	1952	c.1392C>T	c.(1390-1392)ttC>ttT	p.F464F	CTCFL_ENST00000422869.2_Silent_p.F514F|CTCFL_ENST00000422109.2_Intron|CTCFL_ENST00000433949.2_Silent_p.F514F|CTCFL_ENST00000502686.2_Silent_p.F252F|CTCFL_ENST00000371196.2_Silent_p.F514F|CTCFL_ENST00000423479.2_Silent_p.F514F|CTCFL_ENST00000539382.1_Silent_p.F309F|CTCFL_ENST00000426658.2_3'UTR|CTCFL_ENST00000243914.3_Silent_p.F514F|CTCFL_ENST00000432255.2_Silent_p.F370F	NM_001269046.1	NP_001255975.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	514					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			AAAGGCAGGTGAATGGTTTCT	0.438000													34	98					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67713779	67713779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:67713779C>T	ENST00000335894.4	+	16	2435	c.2369C>T	c.(2368-2370)cCt>cTt	p.P790L	IQCH-AS1_ENST00000559298.1_lincRNA|IQCH_ENST00000358767.3_Missense_Mutation_p.P526L|IQCH_ENST00000360277.4_Missense_Mutation_p.P451L|IQCH_ENST00000546225.1_Missense_Mutation_p.P447L	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	790										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		ACCACCGTGCCTCAGACCTCA	0.507000													18	92					0	0	1	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186761062	186761062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186761062G>A	ENST00000169298.3	+	4	1245	c.571G>A	c.(571-573)Gga>Aga	p.G191R	ST6GAL1_ENST00000457772.2_Intron|ST6GAL1_ENST00000448044.1_Missense_Mutation_p.G191R	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	191					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		GTCGTCAGCGGGATCTCTGAA	0.522000													26	141					0	0	1	0	0
FAM198B	51313	broad.mit.edu	37	4	159092246	159092246	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:159092246C>T	ENST00000296530.8	-	2	903	c.282G>A	c.(280-282)gaG>gaA	p.E94E	FAM198B_ENST00000585682.1_Silent_p.E94E|FAM198B_ENST00000393807.5_Silent_p.E94E|RP11-597D13.9_ENST00000503611.1_RNA|FAM198B_ENST00000589306.1_Intron|FAM198B_ENST00000592057.1_Silent_p.E94E	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	94						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						TGCCCTGGGACTCTGGAGGGG	0.632000													25	64					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33313498	33313498	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:33313498C>T	ENST00000242067.6	+	9	1467	c.946C>T	c.(946-948)Caa>Taa	p.Q316*	BBS9_ENST00000396127.2_Nonsense_Mutation_p.Q316*|BBS9_ENST00000354265.4_Nonsense_Mutation_p.Q316*|BBS9_ENST00000425508.2_Nonsense_Mutation_p.Q271*|BBS9_ENST00000355070.2_Nonsense_Mutation_p.Q316*|BBS9_ENST00000350941.3_Nonsense_Mutation_p.Q316*	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	316					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			GCATATTTATCAAGATGTGAC	0.353000									Bardet-Biedl syndrome				19	37					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56459573	56459573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56459573C>T	ENST00000291971.3	+	1	376	c.305C>T	c.(304-306)tCg>tTg	p.S102L	NLRP8_ENST00000590542.1_Missense_Mutation_p.S102L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	102	DAPIN.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GATGTGACTTCGAACATCTTT	0.507000													23	41					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43372307	43372307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43372307G>A	ENST00000244296.2	-	5	1326	c.1189C>T	c.(1189-1191)Cgt>Tgt	p.R397C	PSG1_ENST00000312439.6_Missense_Mutation_p.R397C|PSG1_ENST00000436291.2_Missense_Mutation_p.R397C|PSG1_ENST00000403380.3_Missense_Mutation_p.R304C|PSG1_ENST00000595124.1_Missense_Mutation_p.R304C|PSG1_ENST00000595356.1_Missense_Mutation_p.R397C	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				GCTGAGTTACGAACAGAGCAA	0.448000													139	293					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141955043	141955043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141955043G>A	ENST00000552471.1	-	3	587	c.268C>T	c.(268-270)Cat>Tat	p.H90Y	PRSS58_ENST00000547058.2_Missense_Mutation_p.H90Y			Q8IYP2	PRS58_HUMAN	protease, serine, 58	90	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						AAGTGTGGATGATGAATCATC	0.413000													34	104					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844988	18844988	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18844988C>T	ENST00000412938.1	+	0	3238																											GCAGCGGCCTCCTTGAAGATC	0.572000													9	38					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19560691	19560691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19560691C>T	ENST00000328041.6	+	4	593	c.396C>T	c.(394-396)ttC>ttT	p.F132F		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	132						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ATGACTTCTTCGTCCCTTCCT	0.502000													48	77					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44974300	44974300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:44974300G>A	ENST00000340446.4	-	1	2182	c.1891C>T	c.(1891-1893)Ccc>Tcc	p.P631S		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	631	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		ACTTCAGCGGGGGCCTCCTCA	0.637000													5	27					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46942907	46942907	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46942907G>A	ENST00000429979.1	-	4	1183	c.579C>T	c.(577-579)ttC>ttT	p.F193F	KIAA0226L_ENST00000378784.4_Silent_p.F126F|KIAA0226L_ENST00000389908.3_Silent_p.F193F|KIAA0226L_ENST00000378787.3_Silent_p.F193F|KIAA0226L_ENST00000534925.1_Silent_p.F58F|KIAA0226L_ENST00000409879.2_Silent_p.F36F|KIAA0226L_ENST00000322896.6_Silent_p.F36F|KIAA0226L_ENST00000378781.3_Silent_p.F193F|KIAA0226L_ENST00000378797.2_Silent_p.F193F	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	193										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						CCTCTGGTGAGAAGGAATTCG	0.358000													42	119					0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2511077	2511077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2511077C>T	ENST00000569496.1	+	4	516	c.457C>T	c.(457-459)Cct>Tct	p.P153S	C16orf59_ENST00000563531.1_Missense_Mutation_p.P153S|C16orf59_ENST00000483320.1_5'UTR|C16orf59_ENST00000361837.4_Missense_Mutation_p.P153S			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	153										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				CAAGGGCCACCCTGAGCGCCG	0.706000													6	52					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22902738	22902738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22902738C>T	ENST00000166244.3	+	3	260	c.188C>T	c.(187-189)tCc>tTc	p.S63F	EPHA8_ENST00000374644.4_Missense_Mutation_p.S63F|EPHA8_ENST00000538803.1_Missense_Mutation_p.S63F	NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	63						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GTGGACGAGTCCTTCCAGCCC	0.612000													46	128					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1262101	1262101	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1262101G>A	ENST00000348261.5	+	25	4970	c.4722G>A	c.(4720-4722)gaG>gaA	p.E1574E	CACNA1H_ENST00000565831.1_Silent_p.E1574E|CACNA1H_ENST00000358590.4_Silent_p.E1574E	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1574					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGCGGCGAGAGGAGAAGCGGC	0.692000													13	82					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907882	12907882	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12907882C>T	ENST00000317869.6	-	2	486	c.261G>A	c.(259-261)gaG>gaA	p.E87E		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TCACTTTTGGCTCTGCAGCCA	0.478000													26	267					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79351739	79351739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79351739G>A	ENST00000350881.2	+	3	614	c.424G>A	c.(424-426)Gag>Aag	p.E142K	THBS4_ENST00000511733.1_Missense_Mutation_p.E51K|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	142	TSP N-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CGGCTCCCTAGAGCTCTACCT	0.572000													29	86					0	0	1	0	0
ME3	10873	broad.mit.edu	37	11	86209145	86209145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:86209145C>T	ENST00000543262.1	-	6	891	c.565G>A	c.(565-567)Gag>Aag	p.E189K	ME3_ENST00000323418.6_Missense_Mutation_p.E127K|RP11-317J19.1_ENST00000524610.1_RNA|ME3_ENST00000525957.1_5'UTR|ME3_ENST00000393324.3_Missense_Mutation_p.E189K|ME3_ENST00000359636.2_Missense_Mutation_p.E189K	NM_001161586.1	NP_001155058.1	Q16798	MAON_HUMAN	malic enzyme 3, NADP(+)-dependent, mitochondrial	189					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|skin(3)|stomach(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	AGGATGCGCTCCCCATCAGTC	0.627000													31	85					0	0	1	0	0
SLC3A2	6520	broad.mit.edu	37	11	62655996	62655996	+	Missense_Mutation	SNP	C	C	T	rs138529750		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62655996C>T	ENST00000377892.1	+	13	2041	c.1817C>T	c.(1816-1818)tCg>tTg	p.S606L	SLC3A2_ENST00000535296.1_Missense_Mutation_p.S544L|SLC3A2_ENST00000377891.2_Missense_Mutation_p.S576L|SLC3A2_ENST00000338663.7_Missense_Mutation_p.S474L|SLC3A2_ENST00000536981.1_Missense_Mutation_p.S120L|SLC3A2_ENST00000377890.2_Missense_Mutation_p.S575L|SLC3A2_ENST00000377889.2_Missense_Mutation_p.S513L			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	575					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						GTGGGCCTCTCGGCTGGACTG	0.642000													67	153					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137727218	137727218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137727218C>T	ENST00000314358.5	+	8	2097	c.1897C>T	c.(1897-1899)Cct>Tct	p.P633S	KDM3B_ENST00000542866.1_Intron|KDM3B_ENST00000394866.1_Missense_Mutation_p.P289S	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	633					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						CCGAGAAGAGCCTTCTAATCC	0.493000													36	194					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33855038	33855038	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33855038G>A	ENST00000389232.4	+	11	1043	c.972_splice	c.e11-1	p.E325_splice	RYR3_ENST00000415757.3_Splice_Site_p.E325_splice	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	325	MIR 4.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TATGAATTAGGAACTCAAGGA	0.388000													12	31					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703819	55703819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55703819G>A	ENST00000301532.3	-	1	57	c.58C>T	c.(58-60)Cca>Tca	p.P20S		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GGGCGAGTTGGAAAACCTAAT	0.373000													16	53					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300912	88300912	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88300912G>A	ENST00000418177.2	-	8	2306	c.1939C>T	c.(1939-1941)Cag>Tag	p.Q647*	GRM5_ENST00000455756.2_Nonsense_Mutation_p.Q647*|GRM5_ENST00000305447.4_Nonsense_Mutation_p.Q647*|GRM5_ENST00000393297.1_Nonsense_Mutation_p.Q647*|GRM5_ENST00000305432.5_Nonsense_Mutation_p.Q647*			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	647					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CCAATTCTCTGAAGGTAGCAG	0.493000													5	33					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33578885	33578885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33578885G>A	ENST00000262873.7	+	22	2362	c.2270G>A	c.(2269-2271)gGg>gAg	p.G757E		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	715	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TGCCGCCAAGGGTTCCCCAAC	0.652000													17	46					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113212415	113212415	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113212415C>T	ENST00000401783.2	-	24	4363	c.4027G>A	c.(4027-4029)Gga>Aga	p.G1343R	SVEP1_ENST00000374469.1_Missense_Mutation_p.G1320R|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Missense_Mutation_p.G1343R	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1343	EGF-like 4; calcium-binding (Potential).				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ACGTTCTTTCCACATCGGGTA	0.458000													29	283					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125671766	125671766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125671766G>A	ENST00000431078.1	+	24	4186	c.3822G>A	c.(3820-3822)atG>atA	p.M1274I		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1274					cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CGAGCCAGATGAAGGAGAAGG	0.443000													38	86					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	520865	520865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:520865C>T	ENST00000453061.2	+	10	2213	c.2107C>T	c.(2107-2109)Ctc>Ttc	p.L703F	PIGG_ENST00000310340.5_Missense_Mutation_p.L695F|PIGG_ENST00000383028.4_Missense_Mutation_p.L570F|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000504346.1_Missense_Mutation_p.L614F	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	703					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CCTGGCTGCCCTCTCCCTCCT	0.572000													14	35					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28193847	28193847	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:28193847C>T	ENST00000302326.4	-	1	3639	c.2685G>A	c.(2683-2685)ggG>ggA	p.G895G		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	895							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						TGCTACTGGTCCCGGACGGGC	0.711000			T	ETV6	"""AML, meningioma"""								9	20					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	69978115	69978115	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:69978115C>T	ENST00000355303.5	+	11	1493	c.1188C>T	c.(1186-1188)gcC>gcT	p.A396A	ANO1_ENST00000398543.2_Silent_p.A280A|ANO1_ENST00000538023.1_Silent_p.A396A|ANO1_ENST00000530676.1_Silent_p.A280A|ANO1_ENST00000531349.1_Silent_p.A131A|ANO1_ENST00000316296.5_Silent_p.A368A|RP11-805J14.3_ENST00000530525.1_RNA	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	396					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						CAGCCTGCGCCACGGCCCGCG	0.582000													8	11					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61819654	61819654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61819654G>A	ENST00000373827.2	-	40	5019	c.4849C>T	c.(4849-4851)Ccc>Tcc	p.P1617S	ANK3_ENST00000355288.2_Missense_Mutation_p.P757S|RP11-388P9.2_ENST00000414383.1_RNA|ANK3_ENST00000503366.1_Missense_Mutation_p.P1624S|ANK3_ENST00000280772.1_Intron	NM_001204403.1	NP_001191332.1	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3674	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTTCTAAGGGGAGATTCTATG	0.502000													31	91					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51936919	51936919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51936919C>T	ENST00000371117.3	-	8	871	c.596G>A	c.(595-597)gGa>gAa	p.G199E	PKHD1_ENST00000340994.4_Missense_Mutation_p.G199E	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	199	IPT/TIG 2.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.G199E(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TCACCAGCTTCCCATCTGCCT	0.413000													10	66					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19183983	19183983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19183983G>A	ENST00000375371.3	-	2	346	c.325C>T	c.(325-327)Cag>Tag	p.Q109*	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	109					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AGCACCGGCTGGACATTGTTG	0.552000													32	91					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94693284	94693284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94693284G>A	ENST00000282020.4	+	16	2917	c.2659G>A	c.(2659-2661)Gat>Aat	p.D887N	GRID2_ENST00000510992.1_Missense_Mutation_p.D792N	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	887					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTTGTGCACAGATGACGACAG	0.448000													62	126					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135673	156135673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156135673C>T	ENST00000329476.3	+	2	1071	c.582C>T	c.(580-582)atC>atT	p.I194I	NPY2R_ENST00000506608.1_Silent_p.I194I	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	194					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				TGATTGAGATCATCCCGGACT	0.517000													48	102					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834534	101834534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101834534G>A	ENST00000506729.1	-	1	186	c.15C>T	c.(13-15)gtC>gtT	p.V5V	SLCO6A1_ENST00000379807.3_Silent_p.V5V|SLCO6A1_ENST00000379810.1_Silent_p.V5V|SLCO6A1_ENST00000389019.3_Silent_p.V5V|SLCO6A1_ENST00000513675.1_Silent_p.V5V			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	5						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AGTGCCGGGCGACGCCTACGA	0.706000													29	193					0	0	1	0	0
TAS2R7	50837	broad.mit.edu	37	12	10954432	10954432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10954432G>A	ENST00000240687.2	-	1	794	c.738C>T	c.(736-738)gcC>gcT	p.A246A		NM_023919.2	NP_076408.1	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	246					sensory perception of taste	integral to membrane	taste receptor activity			kidney(1)|large_intestine(1)|lung(3)|skin(2)|stomach(3)	10						ACAAATAGTAGGCAATAAAGA	0.493000													14	56					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70938397	70938397	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70938397C>T	ENST00000334414.6	-	22	5478	c.5434G>A	c.(5434-5436)Gaa>Aaa	p.E1812K	PTPRB_ENST00000550358.1_Missense_Mutation_p.E1724K|PTPRB_ENST00000261266.5_Missense_Mutation_p.E1594K|PTPRB_ENST00000451516.2_Missense_Mutation_p.E1504K|PTPRB_ENST00000538708.1_Missense_Mutation_p.E1504K|PTPRB_ENST00000550857.1_Missense_Mutation_p.E1504K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1594	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTTGTGAATTCCTTCAGGTCC	0.363000													12	46					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	550076	550076	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:550076C>T	ENST00000239830.4	+	12	1413	c.1234C>T	c.(1234-1236)Cga>Tga	p.R412*	CCDC77_ENST00000422000.1_Nonsense_Mutation_p.R380*|CCDC77_ENST00000540180.1_Nonsense_Mutation_p.R380*|CCDC77_ENST00000412006.2_Nonsense_Mutation_p.R380*	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	412						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			ATTGGAGCGTCGACGTATCCT	0.428000													15	57					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10209890	10209890	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10209890C>T	ENST00000418404.3	-	36	5515	c.5352G>A	c.(5350-5352)gaG>gaA	p.E1784E	MYH13_ENST00000570743.1_Silent_p.E1784E|MYH13_ENST00000252172.4_Silent_p.E1784E			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1784					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TCTTCATCCGCTCCAGGTGGG	0.577000													50	64					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768532	117768532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117768532C>T	ENST00000317775.6	-	2	1028	c.343G>A	c.(343-345)Ggg>Agg	p.G115R	NOS1_ENST00000344089.3_Missense_Mutation_p.G115R|NOS1_ENST00000338101.4_Missense_Mutation_p.G115R	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	115	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTGGGGGTCCCATCACCTGTA	0.632000													22	38					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43836363	43836363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43836363C>T	ENST00000372781.3	+	2	482	c.425C>T	c.(424-426)cCt>cTt	p.P142L	SEMG1_ENST00000244069.6_Missense_Mutation_p.P142L	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				ACACAAAATCCTTCTCAAGAT	0.403000													37	103					0	0	1	0	0
KCTD14	65987	broad.mit.edu	37	11	77727683	77727683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:77727683C>T	ENST00000353172.5	-	2	768	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	KCTD14_ENST00000533144.1_Missense_Mutation_p.E212K	NM_001203260.1|NM_001203262.1|NM_023930.3	NP_001190189.1|NP_001190191.1|NP_076419.2	Q9BQ13	KCD14_HUMAN	potassium channel tetramerization domain containing 14	242						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.E242K(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	15	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			AAATGGAATTCGTTTCTTTTG	0.448000													21	44					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075750	145075750	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145075750C>T	ENST00000369359.4	-	1	151	c.113G>A	c.(112-114)cGa>cAa	p.R38Q	PDE4DIP_ENST00000369345.4_Missense_Mutation_p.R38Q|PDE4DIP_ENST00000369348.3_Missense_Mutation_p.R38Q|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R38Q			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGAGGGGTTCGCGTCGCGTC	0.731000			T	PDGFRB	MPD								17	102					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71604584	71604584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71604584C>T	ENST00000355962.4	-	8	1043	c.910G>A	c.(910-912)Gag>Aag	p.E304K	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	304					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	ATTATCACCTCATTGCCAAAA	0.473000													16	49					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89388907	89388907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89388907C>T	ENST00000439576.2	+	7	1597	c.1223C>T	c.(1222-1224)tCc>tTc	p.S408F	ACAN_ENST00000558207.1_Missense_Mutation_p.S408F|ACAN_ENST00000352105.7_Missense_Mutation_p.S408F|ACAN_ENST00000559004.1_Missense_Mutation_p.S408F|ACAN_ENST00000561243.1_Missense_Mutation_p.S408F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	408					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TTCGAGGTCTCCCCCAGTCCC	0.602000													16	60					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11308580	11308580	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:11308580G>A	ENST00000380732.3	-	2	606	c.607C>T	c.(607-609)Cag>Tag	p.Q203*	ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000413512.3_Intron|ARHGAP6_ENST00000380736.1_Intron|ARHGAP6_ENST00000337414.4_Intron			O43182	RHG06_HUMAN	Rho GTPase activating protein 6	196					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CCTAAGATCTGAAGATCATAC	0.363000													26	31					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121420796	121420796	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121420796G>A	ENST00000260197.7	+	15	2308	c.2180_splice	c.e15+1	p.G727_splice		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	727					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GAGAACGAGAGGGTATGTATC	0.502000													25	57					0	0	1	0	0
PRDM11	56981	broad.mit.edu	37	11	45204610	45204610	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:45204610T>G	ENST00000263765.4	+	5	773	c.524T>G	c.(523-525)aTc>aGc	p.I175S	PRDM11_ENST00000424263.2_Missense_Mutation_p.I141S|PRDM11_ENST00000530656.1_Missense_Mutation_p.I175S|PRDM11_ENST00000528980.1_3'UTR			Q9NQV5	PRD11_HUMAN	PR domain containing 11	175	SET.									endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	26						AAGGGCCACATCTTCGGCCCC	0.597000											OREG0020926	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	16					0	0	1	0	0
C11orf42	160298	broad.mit.edu	37	11	6231270	6231270	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6231270G>A	ENST00000316375.2	+	2	313	c.263G>A	c.(262-264)gGa>gAa	p.G88E		NM_173525.2	NP_775796.2	Q8N5U0	CK042_HUMAN	chromosome 11 open reading frame 42	88										endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|soft_tissue(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGCAGGCAGGATCTGAGGGT	0.632000													20	38					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149884829	149884829	+	Silent	SNP	G	G	A	rs144646284	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149884829G>A	ENST00000369146.3	-	2	1054	c.564C>T	c.(562-564)ttC>ttT	p.F188F	SV2A_ENST00000369145.1_Silent_p.F188F	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	188					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TGGGCAGCACGAAGCCCACCA	0.582000													29	100					0	0	1	0	0
STOML3	161003	broad.mit.edu	37	13	39542580	39542580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39542580G>A	ENST00000379631.4	-	6	952	c.608C>T	c.(607-609)tCc>tTc	p.S203F	STOML3_ENST00000423210.1_Missense_Mutation_p.S194F	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	203						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GGCTGCCATGGATCTCTGCAA	0.557000													40	103					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18413795	18413795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18413795G>A	ENST00000440756.2	-	15	2960	c.2858C>T	c.(2857-2859)tCa>tTa	p.S953L	PSD3_ENST00000428502.2_Missense_Mutation_p.S280L|PSD3_ENST00000327040.8_Missense_Mutation_p.S951L|PSD3_ENST00000286485.8_Missense_Mutation_p.S417L|PSD3_ENST00000523619.1_Missense_Mutation_p.S886L			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	952					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GGGGGGATATGAGCGGTGCTC	0.488000													46	153					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43926898	43926898	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43926898G>A	ENST00000537548.1	-	8	1582	c.1338C>T	c.(1336-1338)gcC>gcT	p.A446A	MATN4_ENST00000372751.4_Silent_p.A297A|MATN4_ENST00000353917.5_Silent_p.A364A|MATN4_ENST00000342716.4_Silent_p.A446A|MATN4_ENST00000372756.1_Silent_p.A446A|MATN4_ENST00000360607.5_Silent_p.A405A|MATN4_ENST00000372753.1_Silent_p.A297A|MATN4_ENST00000372754.1_Silent_p.A487A			O95460	MATN4_HUMAN	matrilin 4	487	VWFA 2.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				GCACGTTAAGGGCACGGGGCC	0.662000													38	68					0	0	1	0	0
EGFL6	25975	broad.mit.edu	37	X	13613031	13613031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:13613031G>A	ENST00000361306.1	+	3	521	c.264G>A	c.(262-264)ggG>ggA	p.G88G	EGFL6_ENST00000380602.3_Silent_p.G88G	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	88	EGF-like 1.				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						GATACACCGGGAAAACCTGCA	0.473000													16	14					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130222677	130222677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130222677C>T	ENST00000276211.5	+	12	1907	c.1562C>T	c.(1561-1563)cCc>cTc	p.P521L	ARHGAP36_ENST00000370921.1_Missense_Mutation_p.P385L|ARHGAP36_ENST00000370922.1_Missense_Mutation_p.P509L	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	521					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GGTAACCCTCCCATTCCGGAG	0.527000													20	12					0	0	1	0	0
MYC	4609	broad.mit.edu	37	8	128750684	128750684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:128750684C>T	ENST00000377970.2	+	2	731	c.221C>T	c.(220-222)cCg>cTg	p.P74L	MYC_ENST00000259523.6_Missense_Mutation_p.P59L|MYC_ENST00000524013.1_Missense_Mutation_p.P73L	NM_002467.4	NP_002458.2	P01106	MYC_HUMAN	v-myc avian myelocytomatosis viral oncogene homolog	59					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		CTGCCCACCCCGCCCCTGTCC	0.677000		3	"""A, T"""	"""IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"""	"""Burkitt lymphoma,  amplified in other cancers, B-CLL"""						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	35					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106917017	106917017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106917017G>A	ENST00000369701.3	+	10	1831	c.1604G>A	c.(1603-1605)aGa>aAa	p.R535K		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	535						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GTGGACCTGAGAGGAAGCCCA	0.557000													8	43					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55224579	55224579	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55224579C>T	ENST00000413439.1	+	0	1769																											TCTGAGACCTCTTGGTCCACC	0.622000													21	31					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885216	88885216	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:88885216G>A	ENST00000319675.3	-	1	1080	c.984C>T	c.(982-984)gtC>gtT	p.V328V		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	328										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						CGGCCGCCACGACTCCTTCTT	0.572000													20	57					0	0	1	0	0
RBFOX2	23543	broad.mit.edu	37	22	36142017	36142017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36142017G>A	ENST00000449924.2	-	12	1239	c.1051C>T	c.(1051-1053)Ccc>Tcc	p.P351S	RBFOX2_ENST00000405409.2_Silent_p.T334T|RBFOX2_ENST00000416721.2_Missense_Mutation_p.P347S|RBFOX2_ENST00000359369.4_Silent_p.T337T|RBFOX2_ENST00000397303.2_Missense_Mutation_p.P328S|RBFOX2_ENST00000414461.2_Silent_p.T337T|RBFOX2_ENST00000262829.7_Missense_Mutation_p.P329S|RBFOX2_ENST00000438146.2_Missense_Mutation_p.P422S			O43251	RFOX2_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 2	361	Ala-rich.				estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding			endometrium(4)|large_intestine(7)|lung(7)	18						GCATGGTAGGGGTCGGCTGTG	0.403000													122	376					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75019754	75019754	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75019754T>A	ENST00000261978.4	-	5	1419	c.1033A>T	c.(1033-1035)Acg>Tcg	p.T345S	CTD-2207P18.1_ENST00000554552.1_lincRNA|LTBP2_ENST00000557425.1_Intron|LTBP2_ENST00000556690.1_Missense_Mutation_p.T345S	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	345					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		ATTTTCTCCGTGAGGTTCAGC	0.582000													6	30					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3319755	3319755	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3319755C>T	ENST00000336727.3	+	2	2762	c.1858C>T	c.(1858-1860)Cga>Tga	p.R620*	RGS12_ENST00000543385.1_Nonsense_Mutation_p.R620*|RGS12_ENST00000382788.3_Nonsense_Mutation_p.R620*|RGS12_ENST00000344733.5_Nonsense_Mutation_p.R620*	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	620						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCGAAATGTTCGAAAGACTAA	0.582000													62	117					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105774679	105774679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:105774679G>A	ENST00000393127.2	+	8	1471	c.1025G>A	c.(1024-1026)gGa>gAa	p.G342E	GRIA4_ENST00000530497.1_Missense_Mutation_p.G342E|GRIA4_ENST00000428631.2_Missense_Mutation_p.G342E|GRIA4_ENST00000525187.1_Missense_Mutation_p.G342E|GRIA4_ENST00000282499.5_Missense_Mutation_p.G342E|GRIA4_ENST00000393125.2_Missense_Mutation_p.G342E	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	342					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TGGGGCCAGGGAATTGACATG	0.408000													34	77					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36716041	36716041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36716041G>A	ENST00000244751.2	-	15	1599	c.975C>T	c.(973-975)acC>acT	p.T325T	CPNE5_ENST00000393189.2_Silent_p.T33T|CPNE5_ENST00000459703.1_5'UTR	NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	325										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						AGTTGATCTGGGTCCTAGAAG	0.582000													14	117					0	0	1	0	0
DPY19L3	147991	broad.mit.edu	37	19	32902290	32902290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:32902290C>T	ENST00000587077.1	+	3	406	c.249C>T	c.(247-249)ttC>ttT	p.F83F	DPY19L3_ENST00000342179.5_Intron|DPY19L3_ENST00000392250.2_Intron|DPY19L3_ENST00000586987.1_Intron			Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	0						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					TATGGAGTTTCTTTGACCATT	0.393000													48	87					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319378	21319378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:21319378G>A	ENST00000583088.1	+	3	1619	c.724G>A	c.(724-726)Gag>Aag	p.E242K	KCNJ12_ENST00000331718.5_Missense_Mutation_p.E242K	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CGAGGAGGGCGAGTACATCCC	0.607000										Prostate(3;0.18)			6	54					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77369707	77369707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77369707G>A	ENST00000282849.5	-	12	2223	c.1805C>T	c.(1804-1806)tCc>tTc	p.S602F		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	602	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						ACATGTCCGGGAACATTCTGA	0.567000													76	172					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50329519	50329519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50329519C>T	ENST00000338821.5	-	4	686	c.422G>A	c.(421-423)cGg>cAg	p.R141Q	ATP9A_ENST00000311637.5_Missense_Mutation_p.R126Q|ATP9A_ENST00000402822.1_Missense_Mutation_p.R141Q	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	141					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TGCTGTGAGCCGGCTGTAGAC	0.637000											OREG0026044	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	12					0	0	1	0	0
GPR19	2842	broad.mit.edu	37	12	12814457	12814457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:12814457G>A	ENST00000540510.1	-	2	1118	c.926C>T	c.(925-927)tCc>tTc	p.S309F	GPR19_ENST00000332427.2_Missense_Mutation_p.S309F			Q15760	GPR19_HUMAN	G protein-coupled receptor 19	309						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		GAAAACAAGGGAACTTTTCTT	0.388000													25	64					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31593601	31593601	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31593601C>T	ENST00000376033.2	+	8	1026	c.792C>T	c.(790-792)ccC>ccT	p.P264P	PRRC2A_ENST00000376007.4_Silent_p.P264P|PRRC2A_ENST00000469577.1_3'UTR	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	264	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						TCCCTCCGCCCTATGGACCCC	0.577000													16	74					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353842	77353842	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77353842G>A	ENST00000282849.5	-	16	2854	c.2436C>T	c.(2434-2436)ttC>ttT	p.F812F		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	812	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CAGCGAAGGGGAACTCCCCAG	0.572000													13	78					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1023983	1023983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1023983C>T	ENST00000421673.2	-	25	3396	c.3346G>A	c.(3346-3348)Ggt>Agt	p.G1116S		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1116					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACGCACACACCCTTGTCCAGA	0.682000													12	27					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63477198	63477198	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:63477198C>T	ENST00000536984.2	+	3	1163	c.469C>T	c.(469-471)Cca>Tca	p.P157S	CDH7_ENST00000323011.3_Missense_Mutation_p.P157S|CDH7_ENST00000397968.2_Missense_Mutation_p.P157S			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	157	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TTTGGATGGCCCATACACGGC	0.463000													57	133					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77944601	77944601	+	Missense_Mutation	SNP	C	C	T	rs140615876	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77944601C>T	ENST00000493585.1	-	5	858	c.836G>A	c.(835-837)cGg>cAg	p.R279Q	ISM2_ENST00000429906.1_Silent_p.T313T|ISM2_ENST00000342219.4_Silent_p.T394T|ISM2_ENST00000393684.3_Silent_p.T306T|ISM2_ENST00000412904.1_Silent_p.T313T	NM_182509.3	NP_872315.2	Q6H9L7	ISM2_HUMAN	isthmin 2	0						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						CATGCATGTCCGTAGCATTGC	0.607000													24	127					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6916364	6916364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6916364G>A	ENST00000312053.4	+	12	1442	c.1405G>A	c.(1405-1407)Gaa>Aaa	p.E469K	EMR1_ENST00000381407.5_Missense_Mutation_p.E328K|EMR1_ENST00000381404.4_Missense_Mutation_p.E417K|EMR1_ENST00000250572.8_Missense_Mutation_p.E469K|EMR1_ENST00000450315.3_Missense_Mutation_p.E292K	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	469	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CACAATTGAGGAATCTGAATC	0.438000													38	111					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54849621	54849621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:54849621C>T	ENST00000333896.5	+	8	1407	c.1022C>T	c.(1021-1023)cCc>cTc	p.P341L	SPTBN1_ENST00000356805.4_Missense_Mutation_p.P354L	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	354					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GAGAAACCACCCAAGTAAGAT	0.413000													8	108					0	0	1	0	0
ZNF558	148156	broad.mit.edu	37	19	8922431	8922431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8922431G>A	ENST00000601372.1	-	10	1446	c.735C>T	c.(733-735)ttC>ttT	p.F245F	ZNF558_ENST00000444186.2_Silent_p.F174F|ZNF558_ENST00000301475.1_Silent_p.F245F			Q96NG5	ZN558_HUMAN	zinc finger protein 558	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						AACTGGTGCGGAAAACGTGAA	0.443000													29	52					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2375858	2375858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2375858C>T	ENST00000202625.2	+	3	261	c.200C>T	c.(199-201)gCc>gTc	p.A67V	TGM6_ENST00000381423.1_Missense_Mutation_p.A67V|TGM6_ENST00000477505.1_Intron	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	67					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	GCTTCTGAGGCCCTCCACACC	0.582000													9	27					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900161	151900161	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151900161C>T	ENST00000393900.3	-	3	993	c.640G>A	c.(640-642)Gac>Aac	p.D214N	MAGEA12_ENST00000357916.4_Missense_Mutation_p.D214N|MAGEA12_ENST00000393869.3_Missense_Mutation_p.D214N|CSAG4_ENST00000361201.4_RNA	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	214	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGCACAGTCGCCCTCTTTT	0.582000													87	72					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89346601	89346601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89346601G>A	ENST00000301030.4	-	9	6809	c.6349C>T	c.(6349-6351)Ccg>Tcg	p.P2117S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P2117S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2117	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CAGGGCACCGGCTCCACCTGG	0.697000													3	16					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1418759	1418759	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:1418759G>A	ENST00000446702.2	+	17	2793	c.2166_splice	c.e17+1	p.E722_splice	CNTN6_ENST00000539053.1_Splice_Site_p.E650_splice|CNTN6_ENST00000350110.2_Splice_Site_p.E722_splice			Q9UQ52	CNTN6_HUMAN	contactin 6	722	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TTACGTGGGAGGTAATTTTCT	0.398000													43	99					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54578136	54578136	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54578136C>T	ENST00000336470.4	+	11	1138	c.999C>T	c.(997-999)acC>acT	p.T333T	GNL3L_ENST00000360845.2_Silent_p.T333T	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	333					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						ACCCTGTGACCCCAGTGGAGA	0.627000													6	33					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049038	70049038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70049038G>A	ENST00000330891.5	-	10	1882	c.1656C>T	c.(1654-1656)ccC>ccT	p.P552P	BEST3_ENST00000488961.1_Silent_p.P339P|BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Silent_p.P446P	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	552						chloride channel complex|plasma membrane	chloride channel activity	p.P552P(1)		cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CCTTCTCTGAGGGAGACAGGA	0.542000													19	80					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3329159	3329159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3329159G>A	ENST00000378398.3	+	10	2483	c.2401G>A	c.(2401-2403)Gag>Aag	p.E801K	PRDM16_ENST00000378391.2_Missense_Mutation_p.E800K|PRDM16_ENST00000442529.2_Missense_Mutation_p.E800K|PRDM16_ENST00000441472.2_Missense_Mutation_p.E800K|PRDM16_ENST00000514189.1_Missense_Mutation_p.E801K|PRDM16_ENST00000511072.1_Missense_Mutation_p.E801K|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Missense_Mutation_p.E800K			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	800	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ATCCGGCGAGGAGCAGCCGCT	0.692000			T	EVI1	"""MDS, AML"""								7	21					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	71012625	71012625	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:71012625C>T	ENST00000357250.6	-	1	161	c.3G>A	c.(1-3)atG>atA	p.M1I	COL9A1_ENST00000370496.3_Start_Codon_SNP_p.M1I	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	1					axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AGCAGGTCTTCATTTTCCCAG	0.502000													74	120					0	0	1	0	0
WBP11	51729	broad.mit.edu	37	12	14942001	14942001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14942001G>A	ENST00000261167.2	-	11	1609	c.1376C>T	c.(1375-1377)cCt>cTt	p.P459L	WBP11_ENST00000537574.1_Missense_Mutation_p.P425L	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	459	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						TGGTCCTGGAGGTAAAAGTCG	0.597000													7	25					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008530	120008530	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120008530G>A	ENST00000341846.5	-	1	631	c.210C>T	c.(208-210)ttC>ttT	p.F70F		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	70					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CATTGCCCGCGAACAGGGCGC	0.622000													36	201					0	0	1	0	0
NUFIP1	26747	broad.mit.edu	37	13	45563333	45563333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:45563333G>A	ENST00000379161.4	-	1	285	c.239C>T	c.(238-240)cCc>cTc	p.P80L	RP11-321C24.1_ENST00000437748.2_lincRNA	NM_012345.2	NP_036477.2	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein interacting protein 1	80	Pro-rich.				box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(4)|skin(3)	18		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		GGCGTCGAAGGGGGGCGGAGC	0.662000													16	24					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87735635	87735635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:87735635C>T	ENST00000436978.1	+	48	7884	c.7404C>T	c.(7402-7404)gtC>gtT	p.V2468V	PTPN13_ENST00000511467.1_Silent_p.V2468V|PTPN13_ENST00000427191.2_Silent_p.V2444V|PTPN13_ENST00000316707.6_Silent_p.V2272V|PTPN13_ENST00000411767.2_Silent_p.V2463V	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2463						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		GCTATCAAGTCATCCTTTATG	0.348000													6	54					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154860056	154860056	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:154860056C>T	ENST00000460393.1	+	12	1245	c.1125C>T	c.(1123-1125)ttC>ttT	p.F375F	MME_ENST00000462745.1_Silent_p.F375F|MME_ENST00000493237.1_Silent_p.F375F|MME_ENST00000492661.1_Silent_p.F375F|MME_ENST00000360490.2_Silent_p.F375F	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	375					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CCTGGAGATTCATAATGGATC	0.398000													37	104					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23237025	23237025	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23237025C>T	ENST00000400191.3	+	14	2671	c.2653C>T	c.(2653-2655)Cgc>Tgc	p.R885C	EPHB2_ENST00000374632.3_Missense_Mutation_p.R886C|EPHB2_ENST00000374630.3_Missense_Mutation_p.R885C|EPHB2_ENST00000374627.1_Missense_Mutation_p.R880C	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	885					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CAAGATGATCCGCAATCCCAA	0.637000													12	51					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25488690	25488690	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25488690C>T	ENST00000453082.2	+	0	2318					NR_003343.1																						ACCCTGGTCTCCTGCACTAGC	0.587000													43	111					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177690298	177690298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:177690298C>T	ENST00000390654.3	-	9	907	c.550G>A	c.(550-552)Ggg>Agg	p.G184R	COL23A1_ENST00000407622.1_Missense_Mutation_p.G148R	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	184	Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CCCGGAGGCCCAGCAGCTCCA	0.672000													9	21					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21523896	21523896	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21523896C>T	ENST00000313654.9	+	69	9412	c.9171C>T	c.(9169-9171)atC>atT	p.I3057I	LAMA3_ENST00000587184.1_Silent_p.I1392I|LAMA3_ENST00000399516.3_Silent_p.I3001I|LAMA3_ENST00000269217.6_Silent_p.I1448I|LAMA3_ENST00000588770.1_3'UTR	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	3057	Laminin G-like 4.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATTGAGGATCAAAAGCAAGG	0.468000													11	62					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106824192	106824192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:106824192C>T	ENST00000228347.4	+	14	1627	c.1405C>T	c.(1405-1407)Cgc>Tgc	p.R469C	POLR3B_ENST00000539066.1_Missense_Mutation_p.R411C	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	469					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						GAGTGGTCCTCGCTCCCTCCA	0.493000													22	107					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45028282	45028282	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45028282G>A	ENST00000454753.1	-	0	487							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				TGCAATGGAGGGTTTGGCCAG	0.527000													11	52					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32907432	32907432	+	Missense_Mutation	SNP	C	C	T	rs80358469		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32907432C>T	ENST00000544455.1	+	10	2044	c.1817C>T	c.(1816-1818)cCg>cTg	p.P606L	BRCA2_ENST00000380152.3_Missense_Mutation_p.P606L	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	606					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAAAAATACCGAAAGACCAA	0.318000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			18	57					0	0	1	0	0
TNFSF10	8743	broad.mit.edu	37	3	172241118	172241118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172241118G>A	ENST00000241261.2	-	1	179	c.57C>T	c.(55-57)atC>atT	p.I19I	TNFSF10_ENST00000420541.2_Silent_p.I19I	NM_003810.3	NP_003801.1	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily, member 10	19					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			breast(2)|cervix(1)|large_intestine(1)|lung(6)|ovary(1)|skin(4)	15	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TGAAGATCACGATCAGCACGC	0.562000													29	81					0	0	1	0	0
CLDN6	9074	broad.mit.edu	37	16	3065685	3065685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3065685G>A	ENST00000396925.1	-	3	766	c.338C>T	c.(337-339)tCc>tTc	p.S113F	CLDN6_ENST00000572154.1_Intron|CLDN6_ENST00000328796.4_Missense_Mutation_p.S113F			P56747	CLD6_HUMAN	claudin 6	113					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GCGGGCCTTGGAATCCTTCTC	0.612000													15	44					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241808770	241808770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241808770G>A	ENST00000307503.3	+	2	736	c.349G>A	c.(349-351)Gag>Aag	p.E117K		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	117					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GGACATCGGGGAGCGCATAGG	0.657000													5	58					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60107264	60107264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60107264G>A	ENST00000397786.2	-	7	1196	c.1120C>T	c.(1120-1122)Cat>Tat	p.H374Y		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	374					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TCCACCACATGATTTGCTAAT	0.373000													20	101					0	0	1	0	0
MMAB	326625	broad.mit.edu	37	12	110009504	110009504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110009504G>A	ENST00000545712.2	-	2	539	c.146C>T	c.(145-147)tCc>tTc	p.S49F	MMAB_ENST00000540016.1_Intron|MMAB_ENST00000266839.5_5'UTR	NM_052845.3	NP_443077.1	Q96EY8	MMAB_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblB type	49					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGTCTTCGAGGAAGGCTGTGG	0.498000													9	36					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20966148	20966148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20966148G>A	ENST00000261383.3	-	55	11057	c.11058C>T	c.(11056-11058)aaC>aaT	p.N3686N	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3686	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GGGGGCCGAAGTTTCTTCTCT	0.488000													34	127					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23792369	23792369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23792369C>T	ENST00000354639.3	+	9	1446	c.982C>T	c.(982-984)Cac>Tac	p.H328Y	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Missense_Mutation_p.H351Y|STK31_ENST00000355870.3_Missense_Mutation_p.H351Y|STK31_ENST00000428484.1_Missense_Mutation_p.H328Y	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	351							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTTGACTAACCACTTAGAATA	0.353000													18	58					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123987394	123987394	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123987394G>A	ENST00000369005.1	+	14	8107	c.7767G>A	c.(7765-7767)gcG>gcA	p.A2589A	TACC2_ENST00000368999.1_Silent_p.A679A|TACC2_ENST00000369004.3_Silent_p.A679A|TACC2_ENST00000513429.1_Silent_p.A735A|TACC2_ENST00000358010.1_Silent_p.A735A|TACC2_ENST00000369000.1_Silent_p.A289A|TACC2_ENST00000515603.1_Silent_p.A2544A|TACC2_ENST00000369001.1_Silent_p.A293A|TACC2_ENST00000334433.3_Silent_p.A2589A|TACC2_ENST00000360561.3_Silent_p.A667A|TACC2_ENST00000515273.1_Silent_p.A2593A|TACC2_ENST00000453444.2_Silent_p.A2593A|TACC2_ENST00000260733.3_Silent_p.A667A	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2589						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACACTGCTGCGAAAAACCAGC	0.522000													52	101					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1268745	1268745	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1268745G>A	ENST00000310581.5	-	9	2529	c.2472C>T	c.(2470-2472)tcC>tcT	p.S824S	TERT_ENST00000296820.5_Silent_p.L764L|TERT_ENST00000508104.2_Silent_p.L764L|TERT_ENST00000334602.6_Silent_p.S824S	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	824	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACTGGACGTAGGACCTGGGGC	0.602000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				10	41					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44598104	44598104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44598104G>A	ENST00000322927.2	-	3	528	c.428C>T	c.(427-429)cCc>cTc	p.P143L	ZNF335_ENST00000426788.1_Intron	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GATGAGGTCGGGCCCGATGGT	0.622000													4	31					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53269385	53269385	+	Missense_Mutation	SNP	G	G	A	rs137948996	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53269385G>A	ENST00000338230.3	-	3	1891	c.1624C>T	c.(1624-1626)Cat>Tat	p.H542Y		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	542					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CGATGGCAATGAAGGTATGAC	0.458000													101	262					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61843366	61843366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61843366C>T	ENST00000280772.1	-	33	4275	c.4084G>A	c.(4084-4086)Gga>Aga	p.G1362R	ANK3_ENST00000355288.2_Missense_Mutation_p.G496R|ANK3_ENST00000503366.1_Missense_Mutation_p.G1363R|ANK3_ENST00000373827.2_Missense_Mutation_p.G1356R	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1362					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATAGGTTTTCCTTCCAGAACC	0.294000													22	63					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100831085	100831085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:100831085G>A	ENST00000358544.2	+	47	8776	c.8665G>A	c.(8665-8667)Gac>Aac	p.D2889N	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.D2864N	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2889					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CATAGAACCTGACCTTGTACA	0.378000													23	72					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220104315	220104315	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220104315C>T	ENST00000295759.7	-	9	1183	c.870G>A	c.(868-870)gaG>gaA	p.E290E	GLB1L_ENST00000409640.1_Silent_p.E200E|GLB1L_ENST00000356283.3_Silent_p.E200E|GLB1L_ENST00000497855.1_5'UTR|GLB1L_ENST00000392089.2_Silent_p.E290E			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	290					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGAGCATGTTCTCTAGTCCTT	0.478000													73	168					0	0	1	0	0
MRPL44	65080	broad.mit.edu	37	2	224824624	224824624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:224824624C>T	ENST00000258383.3	+	2	622	c.553C>T	c.(553-555)Cca>Tca	p.P185S		NM_022915.3	NP_075066.1	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44	185	RNase III.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGAAGAATTCCCAGTGCCCCC	0.483000													45	101					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57982295	57982295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57982295C>T	ENST00000309433.6	+	1	79	c.79C>T	c.(79-81)Ctc>Ttc	p.L27F		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				TGAATTCATTCTCCTGGGATT	0.413000													53	125					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54971043	54971043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54971043C>T	ENST00000243052.3	+	15	1978	c.1542C>T	c.(1540-1542)tcC>tcT	p.S514S	PPP1R1A_ENST00000547431.1_3'UTR|PDE1B_ENST00000550620.1_Silent_p.S494S|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Silent_p.S473S	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	514					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						ACGAGCTGTCCCCCTGTGAAG	0.557000													37	149					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74354374	74354374	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74354374C>T	ENST00000226355.3	+	7	834	c.741C>T	c.(739-741)ttC>ttT	p.F247F		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	247	Albumin 2.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCAAAAATTCCCCAAGATTG	0.363000													23	84					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128455945	128455945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128455945C>T	ENST00000297788.4	+	16	3690	c.3323C>T	c.(3322-3324)cCc>cTc	p.P1108L	CCDC136_ENST00000471729.1_3'UTR|CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000487361.1_Intron|CCDC136_ENST00000464832.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	1108	Glu-rich.					integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						CTTGAAAGTCCCGAAGAAAAT	0.493000													7	27					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51096346	51096346	+	Missense_Mutation	SNP	G	G	A	rs138592316		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:51096346G>A	ENST00000395542.2	-	12	2877	c.2693C>T	c.(2692-2694)cCc>cTc	p.P898L	COBL_ENST00000265136.7_Missense_Mutation_p.P816L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	816										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CTTCTGCTGGGGCGATATTGG	0.657000													11	52					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402960	248402960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248402960C>T	ENST00000306687.1	+	1	730	c.730C>T	c.(730-732)Cac>Tac	p.H244Y		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTGCTCCTCCCACCTGTCTGT	0.517000													16	64					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327956	57327956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57327956C>T	ENST00000326441.9	-	10	2217	c.1854G>A	c.(1852-1854)caG>caA	p.Q618Q	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Silent_p.Q494Q|PEG3_ENST00000593695.1_Silent_p.Q492Q|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Silent_p.Q618Q	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	618					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CATACATTTTCTGAAACTCAT	0.443000													15	38					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	138011723	138011723	+	Missense_Mutation	SNP	C	C	T	rs1049289		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138011723C>T	ENST00000252854.4	+	6	1290	c.1103C>T	c.(1102-1104)tCc>tTc	p.S368F	OLFM1_ENST00000371793.3_Missense_Mutation_p.S386F|OLFM1_ENST00000371796.3_Missense_Mutation_p.S359F	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	386	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		GACCCCGTGTCCCTGCAGACC	0.637000													16	35					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	134973999	134973999	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134973999G>A	ENST00000304613.3	+	1	49	c.28G>A	c.(28-30)Gat>Aat	p.D10N	KNDC1_ENST00000368572.2_Missense_Mutation_p.D10N			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	10					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGCCGCGGCGGATCTTTACGA	0.756000													5	12					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85967484	85967484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:85967484C>T	ENST00000263360.6	+	5	1168	c.482C>T	c.(481-483)cCt>cTt	p.P161L	EED_ENST00000327320.4_Missense_Mutation_p.P161L|EED_ENST00000351625.6_Missense_Mutation_p.P161L|EED_ENST00000528180.1_Missense_Mutation_p.P161L	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	161	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				ACGAGCCATCCTCTGCTGGCT	0.358000													10	74					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33134586	33134586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33134586C>T	ENST00000341947.2	-	59	4476	c.4249G>A	c.(4249-4251)Gga>Aga	p.G1417R	COL11A2_ENST00000374714.1_Missense_Mutation_p.G1391R|COL11A2_ENST00000361917.1_Missense_Mutation_p.G1310R|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000395197.1_Missense_Mutation_p.G1357R|COL11A2_ENST00000374713.1_Missense_Mutation_p.G1370R|COL11A2_ENST00000374712.1_Missense_Mutation_p.G1336R|COL11A2_ENST00000374708.4_Missense_Mutation_p.G1331R|COL11A2_ENST00000357486.1_Missense_Mutation_p.G1396R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1417	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCAATCAGTCCAATGAGACCT	0.607000													4	39					0	0	1	0	0
XRRA1	143570	broad.mit.edu	37	11	74559185	74559185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74559185C>T	ENST00000340360.6	-	15	2010	c.1679G>A	c.(1678-1680)aGc>aAc	p.S560N	XRRA1_ENST00000321448.8_Missense_Mutation_p.S285N|XRRA1_ENST00000527087.1_Missense_Mutation_p.S473N	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	560					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						GGACTCTGTGCTCTTGGAGTC	0.577000													7	29					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52200481	52200481	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52200481G>A	ENST00000354534.5	+	27	5389	c.5211G>A	c.(5209-5211)ggG>ggA	p.G1737G	SCN8A_ENST00000545061.1_Silent_p.G1696G	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1737					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GAGATTGTGGGAACCCCTCAG	0.512000													25	52					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456123	5456123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5456123C>T	ENST00000222033.4	+	1	698	c.621C>T	c.(619-621)atC>atT	p.I207I		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	207	PA.					integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GGGGCCAGATCGCCATCCCCT	0.682000													40	89					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230010	56230010	+	Silent	SNP	G	G	A	rs145474756	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56230010G>A	ENST00000279791.1	-	1	867	c.868C>T	c.(868-870)Ctg>Ttg	p.L290L		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					TTATTTCTCAGACTGTAGATC	0.403000													37	96					0	0	1	0	0
ENAH	55740	broad.mit.edu	37	1	225702558	225702558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:225702558G>A	ENST00000366844.2	-	7	1409	c.958C>T	c.(958-960)Cca>Tca	p.P320S	ENAH_ENST00000284563.6_Missense_Mutation_p.P567S|ENAH_ENST00000366843.2_Missense_Mutation_p.P320S	NM_001008493.1	NP_001008493.1	Q8N8S7	ENAH_HUMAN	enabled homolog (Drosophila)	320	Pro-rich.				axon guidance|intracellular transport|T cell receptor signaling pathway	cytosol|filopodium|focal adhesion|lamellipodium|synapse	actin binding|SH3 domain binding|WW domain binding			NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.19)		ggccctggtgggagtggtgga	0.592000													13	36					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803521	185803521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185803521C>T	ENST00000302277.6	+	4	3992	c.3398C>T	c.(3397-3399)tCc>tTc	p.S1133F		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1133						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CAGTTTCTTTCCCAAATCCCA	0.542000													37	79					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169572341	169572341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169572341C>T	ENST00000263686.6	-	10	1665	c.1628G>A	c.(1627-1629)gGa>gAa	p.G543E	SELP_ENST00000458599.2_Intron|SELP_ENST00000367792.2_Intron|SELP_ENST00000367794.2_Missense_Mutation_p.G481E|SELP_ENST00000367786.2_Missense_Mutation_p.G481E|SELP_ENST00000367791.2_Missense_Mutation_p.G419E|SELP_ENST00000367788.2_Missense_Mutation_p.G481E|SELP_ENST00000367793.2_Missense_Mutation_p.G481E	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	543	Sushi 6.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CAAAGAATATCCCTCGTCACA	0.473000													42	84					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129905716	129905716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129905716G>A	ENST00000368654.3	-	13	4763	c.4388C>T	c.(4387-4389)cCc>cTc	p.P1463L	MKI67_ENST00000368653.3_Missense_Mutation_p.P1103L	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1463	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTCTTCTAGGGGTTGGGCCTT	0.493000													65	256					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619443	57619443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57619443C>T	ENST00000349394.5	+	2	1015	c.840C>T	c.(838-840)ttC>ttT	p.F280F		NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	280	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						TCTGTATCTTCGTCTCTTTCC	0.577000													17	69					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35974126	35974126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:35974126C>T	ENST00000297866.5	+	8	1289	c.1223C>T	c.(1222-1224)cCt>cTt	p.P408L		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	408										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						ACAGGACTTCCTGTTTTACTA	0.373000													35	61					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907749	12907749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12907749G>A	ENST00000317869.6	-	2	619	c.394C>T	c.(394-396)Cct>Tct	p.P132S		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						GGAGGAGGAGGAGGTACACGT	0.498000													34	209					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541169	55541169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55541169C>T	ENST00000220676.1	+	4	4875	c.4727C>T	c.(4726-4728)tCt>tTt	p.S1576F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1576					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TCAGAGTCCTCTCCTGATTTA	0.383000													17	69					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075484	9075484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9075484C>T	ENST00000397910.4	-	3	12165	c.11962G>A	c.(11962-11964)Gaa>Aaa	p.E3988K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3990	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATTGCTTGTTCCCTGGTGGAG	0.488000													15	35					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55238216	55238216	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55238216C>T	ENST00000344576.2	+	16	2342	c.2097C>T	c.(2095-2097)atC>atT	p.I699I	EGFR_ENST00000454757.2_Intron|EGFR_ENST00000275493.2_Intron|EGFR_ENST00000455089.1_Intron|EGFR_ENST00000442591.1_Intron	NM_201284.1	NP_958441.1	P00533	EGFR_HUMAN	epidermal growth factor receptor	0	Important for dimerization, phosphorylation and activation.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTGTGATCATCACGGCCTCCT	0.597000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			21	89					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819612	50819612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50819612C>T	ENST00000374115.3	+	1	1266	c.826C>T	c.(826-828)Ctg>Ttg	p.L276L	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	276					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						TCGGGCCAACCTGCCAGTGGG	0.652000													31	56					0	0	1	0	0
FKBP9L	360132	broad.mit.edu	37	7	55755518	55755518	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55755518C>T	ENST00000455909.1	-	0	488					NR_027340.1|NR_027342.1				FK506 binding protein 9-like											endometrium(1)|kidney(1)|lung(3)	5						TGATCACTGTCCGTTTCTCGC	0.517000													17	59					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92647599	92647599	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:92647599C>G	ENST00000318445.6	+	4	1050	c.836C>G	c.(835-837)tCc>tGc	p.S279C	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.S279C|SLCO3A1_ENST00000555549.1_3'UTR	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	279					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TTCTTCTCTTCCCTCTTGATG	0.587000													13	233					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997406	115997406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:115997406G>A	ENST00000264363.2	-	2	1465	c.787C>T	c.(787-789)Cat>Tat	p.H263Y		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	263	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATTCCATCATGAAGCCCCAGA	0.438000													48	166					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228467731	228467731	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228467731G>A	ENST00000366707.4	+	0	7650				OBSCN_ENST00000422127.1_Missense_Mutation_p.G2536S|OBSCN_ENST00000284548.11_Missense_Mutation_p.G2536S|OBSCN_ENST00000570156.2_Missense_Mutation_p.G2965S|OBSCN_ENST00000366709.4_De_novo_Start_OutOfFrame|OBSCN_ENST00000359599.6_Missense_Mutation_p.G1383S			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGCTGATGCTGGTGTCTACCG	0.612000													4	9					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	62029974	62029974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:62029974G>A	ENST00000280772.1	-	5	619	c.428C>T	c.(427-429)cCa>cTa	p.P143L	ANK3_ENST00000503366.1_Missense_Mutation_p.P126L|ANK3_ENST00000373827.2_Missense_Mutation_p.P137L	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	143					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CATATACAATGGCGTGAAACC	0.403000													12	36					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51497470	51497470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51497470C>T	ENST00000371117.3	-	65	11833	c.11558G>A	c.(11557-11559)aGg>aAg	p.R3853K		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3853					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTTCTCCTTCCTAGTCACAGG	0.478000													24	81					0	0	1	0	0
GYS1	2997	broad.mit.edu	37	19	49490508	49490508	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49490508G>A	ENST00000323798.3	-	3	631	c.435C>T	c.(433-435)gaC>gaT	p.D145D	GYS1_ENST00000263276.6_Intron|GYS1_ENST00000540532.1_Silent_p.D65D|GYS1_ENST00000541188.1_Silent_p.D65D|GYS1_ENST00000544287.1_Intron|GYS1_ENST00000457974.1_5'UTR	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	145					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TGGCCTCGCGGTCGTACCACG	0.607000													14	28					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101480449	101480449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101480449G>A	ENST00000392979.3	+	16	1804	c.1443G>A	c.(1441-1443)gtG>gtA	p.V481V	ANO4_ENST00000392977.3_Silent_p.V516V|ANO4_ENST00000550015.1_Silent_p.V36V|ANO4_ENST00000299222.9_Silent_p.V36V	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	516						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TCTGCGTGGTGATTGCTGCCG	0.502000										HNSCC(74;0.22)			90	203					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186944252	186944252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186944252C>T	ENST00000337774.5	-	12	1887	c.1498G>A	c.(1498-1500)Gat>Aat	p.D500N		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	500	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		AGGGTCGGATCTTCCGGATCG	0.577000													3	15					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55690819	55690819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55690819C>T	ENST00000379906.2	+	1	468	c.213C>T	c.(211-213)ggC>ggT	p.G71G	SLC6A2_ENST00000414754.3_Silent_p.G71G|SLC6A2_ENST00000561820.1_Silent_p.G71G|SLC6A2_ENST00000568943.1_Silent_p.G71G|SLC6A2_ENST00000566163.1_Silent_p.G71G|SLC6A2_ENST00000219833.8_Silent_p.G71G	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	71					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CCGTAGTCGGCTTCGCAGTGG	0.672000													25	87					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526305	176526305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176526305C>T	ENST00000367662.3	+	2	2011	c.847C>T	c.(847-849)Ccc>Tcc	p.P283S	PAPPA2_ENST00000367661.3_Missense_Mutation_p.P283S	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	283					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGCTGAGATTCCCCGGGAGGC	0.567000													11	26					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54435228	54435228	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54435228G>A	ENST00000537900.1	+	2	2997	c.2997G>A	c.(2995-2997)gtG>gtA	p.V999V	UNC13C_ENST00000260323.11_Silent_p.V999V|UNC13C_ENST00000545554.1_Intron			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	999					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCAGTTCTGTGGATGAAAAGG	0.328000													23	78					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51400016	51400016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51400016C>T	ENST00000266037.9	+	49	5227	c.5204C>T	c.(5203-5205)tCg>tTg	p.S1735L		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1735	Ser-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GTTCTGTCCTCGTCCCAGGCA	0.562000													17	47					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39227429	39227429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39227429C>T	ENST00000340369.3	-	2	3736	c.3508G>A	c.(3508-3510)Gag>Aag	p.E1170K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1170							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AGGGCAGTCTCCCTGTGCCTT	0.642000													12	29					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222429004	222429004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:222429004G>A	ENST00000281821.2	-	3	311	c.270C>T	c.(268-270)acC>acT	p.T90T	EPHA4_ENST00000409938.1_Silent_p.T90T|EPHA4_ENST00000409854.1_Silent_p.T90T|EPHA4_ENST00000392071.4_Silent_p.T39T	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	90						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CCCCTTCTCGGGTGATCCAAT	0.468000													14	171					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119738993	119738993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:119738993G>A	ENST00000541757.1	+	10	921	c.541G>A	c.(541-543)Ggg>Agg	p.G181R	MARCO_ENST00000327097.4_Missense_Mutation_p.G259R			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	259	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGGAAGCAAAGGGGACAGGGG	0.562000													10	24					0	0	1	0	0
TRBV25-1	28562	broad.mit.edu	37	7	142378989	142378989	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142378989C>T	ENST00000390398.3	+	0	294																											TCAACAGTCTCCAGAATAAGG	0.483000													28	71					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44108899	44108899	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:44108899G>A	ENST00000262419.6	-	15	3731	c.3261C>T	c.(3259-3261)ccC>ccT	p.P1087P	KANSL1_ENST00000432791.1_Silent_p.P1087P|KANSL1_ENST00000393476.3_Silent_p.P381P|KANSL1_ENST00000574590.1_Silent_p.P1087P|KANSL1_ENST00000572904.1_Silent_p.P1087P|KANSL1_ENST00000575318.1_Silent_p.P1023P	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	1087						MLL1 complex	protein binding										GACTCTTGAGGGGGACAATGG	0.617000													9	19					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10870427	10870427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10870427C>T	ENST00000314646.5	+	2	339	c.175C>T	c.(175-177)Cgc>Tgc	p.R59C	DNM2_ENST00000359692.6_Missense_Mutation_p.R59C|DNM2_ENST00000389253.4_Missense_Mutation_p.R59C|DNM2_ENST00000355667.6_Missense_Mutation_p.R59C|DNM2_ENST00000408974.4_Missense_Mutation_p.R59C|DNM2_ENST00000585892.1_Missense_Mutation_p.R59C			P50570	DYN2_HUMAN	dynamin 2	59					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTTCCTTCCCCGCGGTTCAGG	0.567000			"""F, N, Splice, Mis, O"""		ETP ALL								47	236					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141675040	141675040	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:141675040G>A	ENST00000522684.1	-	31	3151	c.2922C>T	c.(2920-2922)ctC>ctT	p.L974L	PTK2_ENST00000340930.3_Silent_p.L987L|PTK2_ENST00000395218.2_Silent_p.L987L|PTK2_ENST00000517712.1_Silent_p.L37L|PTK2_ENST00000521059.1_Silent_p.L974L|PTK2_ENST00000538769.1_Silent_p.L642L|PTK2_ENST00000535192.1_Silent_p.L928L|PTK2_ENST00000519465.1_Silent_p.L602L|PTK2_ENST00000519419.1_Silent_p.L1018L|PTK2_ENST00000430260.2_Silent_p.L284L|PTK2_ENST00000517887.1_Silent_p.L1018L	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	974	Interaction with RGNEF (By similarity).|Interaction with TGFB1I1.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TGGCTGGTAGGAGGGGAATGG	0.542000													11	23					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23776524	23776524	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23776524G>A	ENST00000354639.3	+	8	1239	c.773_splice	c.e8-1	p.E259_splice	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Splice_Site_p.E282_splice|STK31_ENST00000355870.3_Splice_Site_p.E282_splice|STK31_ENST00000428484.1_Splice_Site_p.E259_splice	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	282							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTTTTATAGGGAAAGTTTGGC	0.323000													16	48					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90455056	90455056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:90455056G>A	ENST00000369393.3	-	29	4229	c.4114C>T	c.(4114-4116)Ctc>Ttc	p.L1372F	MDN1_ENST00000428876.1_Missense_Mutation_p.L1372F			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1372					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGCATCGCGAGTCTCCGCATG	0.453000													34	53					0	0	1	0	0
PRSS50	29122	broad.mit.edu	37	3	46753846	46753846	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46753846G>A	ENST00000460241.1	-	11	2718	c.1048C>T	c.(1048-1050)Caa>Taa	p.Q350*	PRSS50_ENST00000315170.7_Nonsense_Mutation_p.Q350*			Q9UI38	TSP50_HUMAN	protease, serine, 50	350	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						ATCCAGTGTTGGTAGGAGGAG	0.657000													6	25					0	0	1	0	0
RBPJ	3516	broad.mit.edu	37	4	26387991	26387991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:26387991C>T	ENST00000342320.4	+	2	210	c.34C>T	c.(34-36)Cct>Tct	p.P12S	RBPJ_ENST00000511401.1_3'UTR|RBPJ_ENST00000348160.4_Missense_Mutation_p.P13S|RBPJ_ENST00000504907.1_Missense_Mutation_p.P12S|RBPJ_ENST00000507561.1_5'UTR|RBPJ_ENST00000361572.6_Missense_Mutation_p.P26S|RBPJ_ENST00000355476.3_Missense_Mutation_p.P12S|RBPJ_ENST00000345843.3_Missense_Mutation_p.P11S|RBPJ_ENST00000342295.1_Missense_Mutation_p.P26S			Q06330	SUH_HUMAN	recombination signal binding protein for immunoglobulin kappa J region	26					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)	15		Breast(46;0.0503)				TGGTGAGCGGCCTCCACCTAA	0.279000													10	43					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1396269	1396269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1396269G>A	ENST00000324385.5	+	25	2663	c.2505G>A	c.(2503-2505)ggG>ggA	p.G835G	BAIAP3_ENST00000426824.3_Silent_p.G800G|BAIAP3_ENST00000397488.2_Silent_p.G817G|BAIAP3_ENST00000421665.2_Silent_p.G764G|BAIAP3_ENST00000564213.1_3'UTR|BAIAP3_ENST00000397489.1_Silent_p.G817G|BAIAP3_ENST00000562208.1_Silent_p.G777G|BAIAP3_ENST00000568887.1_Silent_p.G772G	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	835					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				GGCCCGAGGGGGTGCTCCCCC	0.677000													4	18					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59962312	59962312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59962312G>A	ENST00000444766.3	-	16	2138	c.2063C>T	c.(2062-2064)cCt>cTt	p.P688L	INTS2_ENST00000251334.6_Missense_Mutation_p.P680L	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	688					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						GAATTTGATAGGAATCTGATC	0.333000													3	24					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76744460	76744460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76744460G>A	ENST00000369963.3	-	2	301	c.112C>T	c.(112-114)Cgc>Tgc	p.R38C	IMPG1_ENST00000369950.3_Missense_Mutation_p.R116C			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	116					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TCAGGGATGCGATCCAGAAAG	0.502000													12	59					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19451950	19451950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19451950C>T	ENST00000396229.2	+	3	1339	c.590C>T	c.(589-591)cCa>cTa	p.P197L	TMC5_ENST00000542583.2_Missense_Mutation_p.P197L|TMC5_ENST00000541464.1_Missense_Mutation_p.P197L|TMC5_ENST00000381414.4_Missense_Mutation_p.P197L	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	197						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AGAATCAATCCATACGCAGAC	0.488000													19	112					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187524930	187524930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187524930G>A	ENST00000441802.2	-	19	10959	c.10750C>T	c.(10750-10752)Cct>Tct	p.P3584S		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3584	Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCCATCTGAGGGTCGAGACTG	0.483000										HNSCC(5;0.00058)			8	26					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119699940	119699940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:119699940C>T	ENST00000327097.4	+	1	199	c.64C>T	c.(64-66)Cac>Tac	p.H22Y	MARCO_ENST00000541757.1_5'UTR	NM_006770.3	NP_006761.1	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	22					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGCTGCTTTTCACCAAATTGC	0.423000													22	91					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52476875	52476875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52476875G>A	ENST00000231721.2	-	2	163	c.164C>T	c.(163-165)tCc>tTc	p.S55F		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	55	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity	p.S55C(1)		kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GAGGTTCAGGGAGCCCTGGGG	0.622000													5	9					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90651116	90651116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90651116G>A	ENST00000282146.4	+	2	1437	c.996G>A	c.(994-996)gtG>gtA	p.V332V		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	332						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CAGACGGGGTGGCAGAGAGTG	0.617000													36	70					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20725319	20725319	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:20725319G>A	ENST00000404938.2	+	16	2522	c.1869_splice	c.e16-1	p.D624_splice	ABCB5_ENST00000258738.6_Splice_Site_p.D179_splice	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	179	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TTCCTGTAAGGATATTAAAAA	0.343000													15	43					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55907804	55907804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55907804C>T	ENST00000521992.1	-	3	451	c.306G>A	c.(304-306)acG>acA	p.T102T	CES5A_ENST00000541580.1_Intron|CES5A_ENST00000290567.9_Silent_p.T73T|CES5A_ENST00000518005.1_5'UTR|CES5A_ENST00000520435.1_Silent_p.T73T|CES5A_ENST00000319165.9_Silent_p.T73T	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	73						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GCTGCGGGTTCGTAAATCGCA	0.592000													8	14					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164905885	164905885	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164905885C>T	ENST00000475390.1	-	2	3177	c.2734G>A	c.(2734-2736)Gaa>Aaa	p.E912K	SLITRK3_ENST00000241274.3_Missense_Mutation_p.E912K			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	912						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						ACGTGCAGTTCCTTTAATTTG	0.532000										HNSCC(40;0.11)			30	80					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907971	12907971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12907971C>T	ENST00000317869.6	-	2	397	c.172G>A	c.(172-174)Gat>Aat	p.D58N		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1									p.D58N(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TTCTCCTTATCATATTGAACG	0.468000													32	278					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113085140	113085140	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113085140G>A	ENST00000316851.7	+	7	936	c.936G>A	c.(934-936)gaG>gaA	p.E312E	NCAM1_ENST00000533760.1_Silent_p.E204E|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Silent_p.E321E	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	322	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TGGAATTAGAGGAGCAGGTCA	0.448000													9	23					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269430	30269430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:30269430C>T	ENST00000378981.3	+	4	1141	c.820C>T	c.(820-822)Ccg>Tcg	p.P274S	MAGEB1_ENST00000397548.2_Missense_Mutation_p.P274S|MAGEB1_ENST00000397550.1_Missense_Mutation_p.P274S	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	274	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						CCTATGGGGTCCGAGAGCCTA	0.507000													46	29					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212800	62212800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:62212800G>A	ENST00000519846.1	+	3	886	c.414G>A	c.(412-414)agG>agA	p.R138R	CLVS1_ENST00000325897.4_Silent_p.R138R|RP11-787D18.1_ENST00000518064.1_RNA|CLVS1_ENST00000518592.1_Intron			Q8IUQ0	CLVS1_HUMAN	clavesin 1	138	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						ATTACGGCAGGAAGATTCTTT	0.448000													4	49					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13845085	13845085	+	Missense_Mutation	SNP	C	C	T	rs146830682		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13845085C>T	ENST00000265104.4	-	32	5236	c.5132G>A	c.(5131-5133)cGa>cAa	p.R1711Q		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1711	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.R1711Q(1)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AAAGCACAGTCGTTTTTTCTC	0.453000									Kartagener syndrome				9	52					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140011714	140011714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140011714G>A	ENST00000302014.6	-	2	1484	c.855C>T	c.(853-855)ttC>ttT	p.F285F	CD14_ENST00000401743.2_Silent_p.F285F	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	285					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGCCCAGCGAACGACAGAT	0.612000													13	71					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209644	140209644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140209644G>A	ENST00000529310.1	+	1	2082	c.1968G>A	c.(1966-1968)gaG>gaA	p.E656E	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACGGTGAGCCGGCGCTGA	0.697000													18	84					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229738200	229738200	+	Silent	SNP	G	G	A	rs143676179		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:229738200G>A	ENST00000366675.3	-	4	802	c.714C>T	c.(712-714)gcC>gcT	p.A238A	TAF5L_ENST00000366676.1_Silent_p.A238A|TAF5L_ENST00000258281.2_Silent_p.A238A	NM_001025247.1	NP_001020418.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	238					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				AGACCTCTAGGGCAGCCTCGT	0.552000													11	109					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788463	42788463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42788463G>A	ENST00000372980.3	-	2	1836	c.964C>T	c.(964-966)Ctg>Ttg	p.L322L		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	322					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CCGTGGCGCAGGTTGTCCAGC	0.662000													17	36					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139390781	139390781	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139390781G>A	ENST00000277541.6	-	34	7485	c.7410C>T	c.(7408-7410)tcC>tcT	p.S2470S		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	2470					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.S2472fs*6(1)|p.S2472fs*8(1)|p.S2471fs*1(1)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGACCAGCGAGGATGGCAGCG	0.697000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			5	8					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131792974	131792974	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131792974G>A	ENST00000286355.5	-	18	5510	c.3418C>T	c.(3418-3420)Ctg>Ttg	p.L1140L	ADCY8_ENST00000377928.3_Silent_p.L1009L	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1140					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGGTCCTTCAGGATGAGATAG	0.498000										HNSCC(32;0.087)			56	99					0	0	1	0	0
SECTM1	6398	broad.mit.edu	37	17	80282490	80282490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80282490C>T	ENST00000269389.3	-	3	721	c.371G>A	c.(370-372)aGa>aAa	p.R124K	SECTM1_ENST00000580437.1_Missense_Mutation_p.R124K	NM_003004.2	NP_002995.1	Q8WVN6	SCTM1_HUMAN	secreted and transmembrane 1	124					immune response|mesoderm development|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular space|Golgi apparatus|integral to membrane|plasma membrane	cytokine activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(1)	4	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			TCTGTTATTTCTCTGGTGTCC	0.642000													20	54					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56952689	56952689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56952689C>T	ENST00000504904.3	-	7	2394	c.1675G>A	c.(1675-1677)Gaa>Aaa	p.E559K	ZNF667_ENST00000292069.6_Missense_Mutation_p.E559K|ZNF667_ENST00000342634.3_Missense_Mutation_p.E687K|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTCCCACATTCATTACATTCA	0.408000													23	115					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118957063	118957063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118957063C>T	ENST00000334549.1	+	1	64	c.64C>T	c.(64-66)Cct>Tct	p.P22S		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	22						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		AAAGCTCTTCCCTGGCCTCTG	0.632000													24	48					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22134094	22134094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22134094C>T	ENST00000408935.1	+	1	798	c.798C>T	c.(796-798)tcC>tcT	p.S266S		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CCAGCTTCTCCATTGACAAGG	0.507000													15	54					0	0	1	0	0
JKAMP	51528	broad.mit.edu	37	14	59970692	59970692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:59970692C>T	ENST00000554271.1	+	7	1406	c.880C>T	c.(880-882)Ctt>Ttt	p.L294F	JKAMP_ENST00000356057.5_Missense_Mutation_p.L288F|JKAMP_ENST00000261247.9_Missense_Mutation_p.L280F|RP11-701B16.2_ENST00000554253.1_RNA|JKAMP_ENST00000425728.2_Missense_Mutation_p.L274F			Q9P055	JKAMP_HUMAN	JNK1/MAPK8-associated membrane protein	295					ER-associated protein catabolic process|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ubiquitin protein ligase binding			breast(1)|endometrium(1)|kidney(1)|lung(3)	6						AGATTTGCCCCTTTTGGCTTT	0.418000													36	78					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369068	22369068	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22369068C>T	ENST00000332663.2	+	1	591	c.493C>T	c.(493-495)Cga>Tga	p.R165*	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTCATTGTTCGACTTCCTTT	0.498000													42	205					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128480613	128480613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128480613G>A	ENST00000325888.8	+	10	1822	c.1561G>A	c.(1561-1563)Gag>Aag	p.E521K	FLNC_ENST00000346177.6_Missense_Mutation_p.E521K	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	521					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GGGCACAGAGGAGCCAGTGAA	0.602000													28	58					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70974966	70974966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70974966C>T	ENST00000334414.6	-	10	2472	c.2428G>A	c.(2428-2430)Gaa>Aaa	p.E810K	PTPRB_ENST00000550358.1_Missense_Mutation_p.E810K|PTPRB_ENST00000551525.1_Missense_Mutation_p.E809K|PTPRB_ENST00000261266.5_Missense_Mutation_p.E592K|PTPRB_ENST00000451516.2_Missense_Mutation_p.E502K|PTPRB_ENST00000538708.1_Missense_Mutation_p.E592K|PTPRB_ENST00000550857.1_Missense_Mutation_p.E502K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	592	Fibronectin type-III 9.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACCACATTTTCATGGATCAGT	0.463000													42	137					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53560056	53560056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:53560056G>A	ENST00000357758.3	-	3	1302	c.1119C>T	c.(1117-1119)acC>acT	p.T373T	DDHD1_ENST00000323669.5_Silent_p.T373T|DDHD1_ENST00000395606.1_Silent_p.T380T	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	373					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					CCAGTTTTTGGGTAACTGTTC	0.323000													8	49					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6128845	6128845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6128845G>A	ENST00000261405.5	-	28	3993	c.3739C>T	c.(3739-3741)Ccc>Tcc	p.P1247S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1247					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GCATCTGTGGGAGGCACCACC	0.567000													13	24					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4333791	4333791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4333791C>T	ENST00000600324.1	-	3	264	c.197G>A	c.(196-198)gGa>gAa	p.G66E	STAP2_ENST00000594605.1_Missense_Mutation_p.G66E	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	66	PH.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAAATGCTCCCAAGTTGAG	0.567000													23	51					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29002037	29002037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29002037C>T	ENST00000282397.4	-	9	1379	c.1128G>A	c.(1126-1128)gcG>gcA	p.A376A	FLT1_ENST00000541932.1_Silent_p.A376A|FLT1_ENST00000539099.1_Silent_p.A376A	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	376	Ig-like C2-type 4.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ATTTCTCAGTCGCAGGTAACC	0.398000													27	100					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64873549	64873549	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64873549G>A	ENST00000533854.1	+	2	336	c.99G>A	c.(97-99)tgG>tgA	p.W33*	CACNG5_ENST00000169565.3_Nonsense_Mutation_p.W33*|CACNG5_ENST00000307139.3_Nonsense_Mutation_p.W33*			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	33					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CCGACTACTGGCTGTACCTGG	0.607000													17	72					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204588393	204588393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204588393G>A	ENST00000367175.1	-	1	2940	c.728C>T	c.(727-729)tCc>tTc	p.S243F	LRRN2_ENST00000367176.3_Missense_Mutation_p.S243F|LRRN2_ENST00000367177.3_Missense_Mutation_p.S243F			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	243					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GTCATAGAAGGAGAGGCTCTC	0.642000													15	59					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248636944	248636944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248636944C>T	ENST00000359594.2	+	1	318	c.293C>T	c.(292-294)tCc>tTc	p.S98F		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATACCATTTCCCCGTCAGGC	0.542000													15	41					0	0	1	0	0
MOSPD3	64598	broad.mit.edu	37	7	100210593	100210593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100210593C>T	ENST00000393950.2	+	1	461	c.179C>T	c.(178-180)cCc>cTc	p.P60L	MOSPD3_ENST00000424091.2_Missense_Mutation_p.P60L|MOSPD3_ENST00000379527.2_Missense_Mutation_p.P60L|MOSPD3_ENST00000223054.4_Missense_Mutation_p.P60L	NM_023948.4	NP_076438.1	O75425	MSPD3_HUMAN	motile sperm domain containing 3	60	MSP.					integral to membrane	structural molecule activity			breast(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CTCTATAACCCCACAGGAACT	0.647000													28	139					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45484823	45484823	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45484823G>A	ENST00000334940.6	+	7	794	c.660_splice	c.e7+1	p.R220_splice	RASSF4_ENST00000374417.2_3'UTR|RASSF4_ENST00000340258.4_Splice_Site_p.R211_splice|RASSF4_ENST00000472561.1_3'UTR			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	211	Ras-associating.				cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						ACAAATTTAGGGTAAGCCTGG	0.577000													10	21					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110830538	110830538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110830538G>A	ENST00000375820.4	-	32	2620	c.2499C>T	c.(2497-2499)ttC>ttT	p.F833F		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	833	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCAGTCCAGGGAATCCGGGGA	0.522000													28	93					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37398589	37398589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37398589G>A	ENST00000535679.1	-	6	768	c.769C>T	c.(769-771)Ctt>Ttt	p.L257F	SULT6B1_ENST00000407963.1_Missense_Mutation_p.L219F|SULT6B1_ENST00000260637.3_Missense_Mutation_p.L219F|SULT6B1_ENST00000379149.2_Missense_Mutation_p.L153F			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	257						cytoplasm	sulfotransferase activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				TTGCGGAAAAGGAATGGGCCG	0.463000													41	115					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152882619	152882619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152882619G>A	ENST00000368764.3	+	2	410	c.346G>A	c.(346-348)Gat>Aat	p.D116N	IVL_ENST00000392667.2_5'UTR			P07476	INVO_HUMAN	involucrin	116					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AACACAAAGGGATCAGCAGCT	0.473000													21	44					0	0	1	0	0
TMCC3	57458	broad.mit.edu	37	12	94965318	94965318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:94965318G>A	ENST00000261226.4	-	4	1458	c.1327C>T	c.(1327-1329)Cgc>Tgc	p.R443C	TMCC3_ENST00000551457.1_Missense_Mutation_p.R412C	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	443						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						ATGTGGCAGCGACTCTTCATC	0.478000													53	91					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99456460	99456460	+	Missense_Mutation	SNP	C	C	T	rs45483397		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:99456460C>T	ENST00000268035.6	+	8	2388	c.1777C>T	c.(1777-1779)Cat>Tat	p.H593Y	IGF1R_ENST00000558762.1_Missense_Mutation_p.H593Y	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	593	Fibronectin type-III 1.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GGAGAACGACCATATCCGTGG	0.552000													27	137					0	0	1	0	0
SF3A3	10946	broad.mit.edu	37	1	38435103	38435103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38435103G>A	ENST00000373019.4	-	14	2159	c.1204C>T	c.(1204-1206)Cta>Tta	p.L402L	SF3A3_ENST00000448721.2_Silent_p.L349L	NM_006802.2	NP_006793.1	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3, 60kDa	402					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|prostate(2)	12	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TTGATATTTAGGCCATGAAGC	0.398000													11	96					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31404690	31404690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31404690C>T	ENST00000389202.2	+	1	58	c.9C>T	c.(7-9)ttC>ttT	p.F3F		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	3					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGATGACCTTCGGCACTGTGC	0.587000													34	87					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881789	228881789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228881789C>T	ENST00000392056.3	-	7	3827	c.3781G>A	c.(3781-3783)Gat>Aat	p.D1261N	SPHKAP_ENST00000344657.5_Missense_Mutation_p.D1261N	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1261						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCAAAGCCATCTAAAGAGTTG	0.542000													18	64					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439343	150439343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150439343G>A	ENST00000358647.3	+	3	483	c.116G>A	c.(115-117)gGg>gAg	p.G39E	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACAGGCTGCGGGAAAAGTGCC	0.507000													31	73					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20976437	20976437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:20976437C>T	ENST00000380249.1	+	38	4515	c.4151C>T	c.(4150-4152)cCt>cTt	p.P1384L	FOCAD_ENST00000338382.6_Missense_Mutation_p.P1384L|FOCAD_ENST00000605086.1_Missense_Mutation_p.P820L	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	1384						integral to membrane	binding										TCTGTGCCTCCTTCCCTTCTT	0.418000													25	245					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52880906	52880906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52880906G>A	ENST00000356971.3	-	9	1295	c.806C>T	c.(805-807)cCc>cTc	p.P269L	ICK_ENST00000350082.5_Missense_Mutation_p.P269L	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	269	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TCGTTTCTTGGGATCCCACTG	0.408000													38	79					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120530855	120530855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120530855G>A	ENST00000397558.2	+	9	1612	c.1612G>A	c.(1612-1614)Gaa>Aaa	p.E538K	CCDC64_ENST00000446727.2_Missense_Mutation_p.E209K|CCDC64_ENST00000546857.1_3'UTR|CCDC64_ENST00000257583.4_Missense_Mutation_p.E235K	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	538					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCACCTGAAAGAACGGAGCCA	0.622000													18	66					0	0	1	0	0
EIF2D	1939	broad.mit.edu	37	1	206769163	206769163	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206769163G>A	ENST00000271764.2	-	13	1621	c.1413C>T	c.(1411-1413)gcC>gcT	p.A471A	EIF2D_ENST00000367114.3_Silent_p.A347A|EIF2D_ENST00000472709.2_5'UTR	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	471					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						TCACTTGATAGGCAGGCTGTA	0.438000													42	164					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160977153	160977153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160977153C>T	ENST00000447678.1	-	31	4997	c.4877G>A	c.(4876-4878)gGc>gAc	p.G1626D	LPA_ENST00000316300.5_Missense_Mutation_p.G1626D	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4134	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGAGAATGTGCCTCGATAACT	0.483000													27	149					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205273195	205273195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205273195C>T	ENST00000367157.3	-	7	1396	c.1270G>A	c.(1270-1272)Gag>Aag	p.E424K		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	424					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGAGGGTCCTCCTGTACCCCT	0.627000													27	82					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102851377	102851377	+	Missense_Mutation	SNP	G	G	A	rs34289672		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102851377G>A	ENST00000264257.2	+	11	1444	c.1318G>A	c.(1318-1320)Gaa>Aaa	p.E440K	IL1RL2_ENST00000441515.2_Missense_Mutation_p.E322K|IL1RL2_ENST00000481806.1_3'UTR|IL1RL2_ENST00000539491.1_Missense_Mutation_p.E440K	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	440	TIR.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						TGTCATCGATGAAAACGTTAA	0.463000													29	68					0	0	1	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841655	8841655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8841655G>A	ENST00000324060.2	+	1	340	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCTGCGGGGAGAAGGTGCCAC	0.547000													26	63					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177553	89177553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:89177553C>T	ENST00000561129.2	+	1	599	c.469C>T	c.(469-471)Ctg>Ttg	p.L157L	TGIF2LX_ENST00000283891.5_Silent_p.L157L			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	157						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						TGTACAAAGCCTGCCCCTGTG	0.612000													9	29					0	0	1	0	0
MBD3	53615	broad.mit.edu	37	19	1581114	1581114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1581114G>A	ENST00000590550.2	-	4	859	c.486C>T	c.(484-486)ttC>ttT	p.F162F	MBD3_ENST00000434436.3_Silent_p.F218F|MBD3_ENST00000592012.1_Silent_p.F186F|MBD3_ENST00000156825.1_Silent_p.F218F			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	218					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGTCACCATGAAGGCTTTGC	0.647000													11	42					0	0	1	0	0
IGJ	3512	broad.mit.edu	37	4	71527857	71527857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71527857G>A	ENST00000254801.4	-	2	309	c.140C>T	c.(139-141)tCt>tTt	p.S47F	ENAM_ENST00000472903.1_3'UTR|IGJ_ENST00000543780.1_Missense_Mutation_p.S63F	NM_144646.3	NP_653247.1	P01591	IGJ_HUMAN	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	47					immune response	extracellular region	antigen binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7			Lung(101;0.235)			ATCTTCGGAAGAACGGATGAT	0.388000													20	104					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179590257	179590257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179590257C>T	ENST00000589042.1	-	71	20898	c.20674G>A	c.(20674-20676)Gaa>Aaa	p.E6892K	TTN_ENST00000342992.6_Missense_Mutation_p.E5648K|TTN_ENST00000591111.1_Missense_Mutation_p.E6575K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|RP11-171I2.1_ENST00000590024.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6575	Ig-like 50.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCACTTCTTCCTTCTCTTTA	0.433000													18	62					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701557	143701557	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143701557C>T	ENST00000408922.2	+	1	536	c.468C>T	c.(466-468)tcC>tcT	p.S156S		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TTGGCATCTCCCTGGCGAAGA	0.532000													27	46					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71265027	71265027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71265027C>T	ENST00000399575.2	+	2	199	c.25C>T	c.(25-27)Ctg>Ttg	p.L9L	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	9					regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				CTTCTTGGGCCTGTTGGCTCT	0.318000													4	46					0	0	1	0	0
SBK2	646643	broad.mit.edu	37	19	56041213	56041213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56041213G>A	ENST00000413299.1	-	4	971	c.934C>T	c.(934-936)Ccc>Tcc	p.P312S	SBK2_ENST00000344158.3_Missense_Mutation_p.P312S	NM_001101401.2	NP_001094871.2	P0C263	SBK2_HUMAN	SH3 domain binding kinase family, member 2	312	Protein kinase.						ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						CTCCTTCGGGGGTGAGGGTCC	0.751000													14	23					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219538350	219538350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219538350C>T	ENST00000295709.3	+	3	366	c.87C>T	c.(85-87)gtC>gtT	p.V29V	STK36_ENST00000392106.2_Silent_p.V29V|STK36_ENST00000392105.3_Silent_p.V29V|STK36_ENST00000440309.1_Silent_p.V29V	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	29	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		ACTGACAGGTCGTGGCCCTGA	0.458000													9	45					0	0	1	0	0
DHRS7C	201140	broad.mit.edu	37	17	9676110	9676110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:9676110C>T	ENST00000330255.4	-	5	716	c.704G>A	c.(703-705)gGa>gAa	p.G235E	DHRS7C_ENST00000571134.1_Missense_Mutation_p.G234E	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	235						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						TTCCCAGTTTCCTTGCTCTGG	0.562000													17	23					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76755238	76755238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76755238G>A	ENST00000536229.3	+	2	3341	c.2632G>A	c.(2632-2634)Ggc>Agc	p.G878S	SALL3_ENST00000575389.2_Missense_Mutation_p.G1011S|SALL3_ENST00000537592.2_Missense_Mutation_p.G1083S			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1083					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCTGCCCGCGGGCGTCCAGGT	0.711000													11	12					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86327250	86327250	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:86327250G>A	ENST00000263857.6	-	2	501	c.123C>T	c.(121-123)agC>agT	p.S41S	POLR1A_ENST00000409681.1_Silent_p.S41S			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	41					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						GGTTCCCCAGGCTGTCCAGGT	0.483000													25	63					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93104332	93104332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93104332C>T	ENST00000298050.3	+	7	775	c.675C>T	c.(673-675)ttC>ttT	p.F225F		NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	225										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				GAGATGAGTTCATTATTGAAA	0.348000													10	19					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8188758	8188758	+	Missense_Mutation	SNP	C	C	T	rs138166112		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8188758C>T	ENST00000600128.1	-	23	3280	c.2866G>A	c.(2866-2868)Gat>Aat	p.D956N	FBN3_ENST00000601739.1_Missense_Mutation_p.D956N|FBN3_ENST00000270509.2_Missense_Mutation_p.D956N			Q75N90	FBN3_HUMAN	fibrillin 3	956	TB 5.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GACTCGGGATCCGGGCAGGCC	0.662000													9	37					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43507295	43507295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43507295C>T	ENST00000300215.3	-	3	975	c.518G>A	c.(517-519)aGa>aAa	p.R173K	EPB42_ENST00000441366.2_Missense_Mutation_p.R143K|EPB42_ENST00000540029.1_Intron			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	143					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		AAACTTACCTCTATTCCAGGG	0.597000													9	32					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	939091	939091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:939091C>T	ENST00000265846.5	-	9	1051	c.832G>A	c.(832-834)Gat>Aat	p.D278N	ADAP1_ENST00000539900.1_Missense_Mutation_p.D289N|ADAP1_ENST00000449296.2_Missense_Mutation_p.D206N	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	278	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						CTGCGGTCATCCATGGTGAAC	0.637000													15	23					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189689737	189689737	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189689737C>T	ENST00000319332.5	-	12	1956	c.1759G>A	c.(1759-1761)Gat>Aat	p.D587N	LEPREL1_ENST00000427335.2_Missense_Mutation_p.D406N	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	587	Fe2OG dioxygenase.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GCCTCTGGATCCAACAAACAG	0.453000													14	34					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719243	140719243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140719243G>A	ENST00000394576.2	+	1	705	c.705G>A	c.(703-705)gcG>gcA	p.A235A	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1												p.A235A(2)		breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGGATGCGAACGACAATG	0.592000													28	82					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92495284	92495284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92495284G>A	ENST00000298047.6	+	4	3949	c.3932G>A	c.(3931-3933)gGg>gAg	p.G1311E	FAT3_ENST00000525166.1_Missense_Mutation_p.G1161E|RP11-203F8.1_ENST00000529884.1_RNA|FAT3_ENST00000409404.2_Missense_Mutation_p.G1311E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1311	Cadherin 12.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTAAAACTGGGATGGTTTCT	0.453000										TCGA Ovarian(4;0.039)			13	75					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36362863	36362863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36362863G>A	ENST00000221891.4	+	6	967	c.775G>A	c.(775-777)Gag>Aag	p.E259K	APLP1_ENST00000537454.2_Missense_Mutation_p.E220K|APLP1_ENST00000586861.1_Missense_Mutation_p.E253K	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	259					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TTACTTCGTGGAGCCTCCGCA	0.622000													50	173					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314090	67314090	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67314090C>T	ENST00000360461.5	+	1	2678	c.143C>T	c.(142-144)cCt>cTt	p.P48L	PLEKHG4_ENST00000427155.2_Missense_Mutation_p.P48L|PLEKHG4_ENST00000379344.3_Missense_Mutation_p.P48L|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.P48L	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	48					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		GACCCAGGTCCTCCAAGACCA	0.602000													8	61					0	0	1	0	0
WFDC2	10406	broad.mit.edu	37	20	44108722	44108722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44108722C>T	ENST00000342873.3	+	1	644	c.211C>T	c.(211-213)Ccc>Tcc	p.P71S	WFDC2_ENST00000339946.3_Missense_Mutation_p.P74S|WFDC2_ENST00000372676.3_Missense_Mutation_p.P122S|WFDC2_ENST00000488143.1_3'UTR			Q14508	WFDC2_HUMAN	WAP four-disulfide core domain 2	122	WAP 1.			SL -> LLC (in Ref. 1; CAA44869 and 2; AAL37485).	proteolysis|spermatogenesis	extracellular space	serine-type endopeptidase inhibitor activity			lung(1)	1		Myeloproliferative disorder(115;0.0122)				CTGTGTCACTCCCAATTTCTG	0.572000													31	110					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730213	57730213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57730213G>A	ENST00000281282.5	+	2	94	c.16G>A	c.(16-18)Ggt>Agt	p.G6S		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	6	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		GCTGTATTTCGGTGAATATCA	0.443000													141	278					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64981737	64981737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:64981737G>A	ENST00000268603.4	-	13	2775	c.2160C>T	c.(2158-2160)ttC>ttT	p.F720F	CDH11_ENST00000566827.1_Silent_p.F594F|CDH11_ENST00000394156.3_3'UTR	NM_001797.2	NP_001788.2	P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	720					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TCGTGTTGATGAAGTCATCGA	0.532000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			34	78					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325940	158325940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158325940C>T	ENST00000434258.1	+	4	954	c.943C>T	c.(943-945)Ctg>Ttg	p.L315L	CD1E_ENST00000368157.1_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368165.3_Intron|CD1E_ENST00000368163.3_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368167.3_Intron|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000368161.3_Intron|CD1E_ENST00000368160.3_Intron|CD1E_ENST00000444681.2_Intron|CD1E_ENST00000368166.3_Intron			P15812	CD1E_HUMAN	CD1e molecule	0					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GAAAATAGCCCTGGGGCTTTT	0.473000													8	26					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167675260	167675260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167675260C>T	ENST00000519204.1	+	26	7071	c.6953C>T	c.(6952-6954)tCc>tTc	p.S2318F	TENM2_ENST00000545108.1_Missense_Mutation_p.S2438F|TENM2_ENST00000518659.1_Missense_Mutation_p.S2439F|TENM2_ENST00000520394.1_Missense_Mutation_p.S2200F|TENM2_ENST00000403607.2_Missense_Mutation_p.S2263F					teneurin transmembrane protein 2																		CGATGGACCTCCCCAGACTAT	0.522000													14	40					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31432838	31432838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31432838C>T	ENST00000261592.5	-	11	2182	c.1885G>A	c.(1885-1887)Gaa>Aaa	p.E629K	NOL4_ENST00000535475.1_Missense_Mutation_p.E410K|NOL4_ENST00000269185.4_Missense_Mutation_p.E413K|NOL4_ENST00000535384.1_Missense_Mutation_p.E344K|NOL4_ENST00000538587.1_Missense_Mutation_p.E555K|NOL4_ENST00000589544.1_Missense_Mutation_p.E527K	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	629						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TTTTCCAGTTCATCTGCAGAT	0.418000													6	65					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223272	44223272	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44223272G>A	ENST00000244314.5	+	2	761	c.562G>A	c.(562-564)Gcc>Acc	p.A188T		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	188						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CTTCAGAGAGGCCGCTGTCCT	0.672000													16	42					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32181595	32181595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32181595C>T	ENST00000375023.3	-	14	2328	c.2190G>A	c.(2188-2190)atG>atA	p.M730I	NOTCH4_ENST00000465528.1_5'UTR	NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	730	EGF-like 19.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GACAAGCTGTCATCTCCTCAC	0.597000													15	38					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75886311	75886311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75886311C>T	ENST00000274364.6	+	8	1016	c.719C>T	c.(718-720)cCa>cTa	p.P240L	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	240					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CTAAGAAACCCAAATGCGGTT	0.378000													38	57					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234550	21234550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21234550C>T	ENST00000233242.1	-	26	5317	c.5190G>A	c.(5188-5190)aaG>aaA	p.K1730K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1730					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTGACTGACCTTGAAGTTGA	0.448000													79	274					0	0	1	0	0
CCDC74A	90557	broad.mit.edu	37	2	132290506	132290506	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132290506C>T	ENST00000295171.6	+	6	1084	c.946C>T	c.(946-948)Ccc>Tcc	p.P316S	CCDC74A_ENST00000409856.3_Missense_Mutation_p.P250S|CCDC74A_ENST00000467992.2_3'UTR	NM_001258304.1|NM_001258305.1|NM_138770.2	NP_001245233.1|NP_001245234.1|NP_620125.1	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	316										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						AGCTAGCTTTCCCAGGTGAGT	0.647000													26	65					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124303686	124303686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124303686G>A	ENST00000291478.4	+	1	181	c.18G>A	c.(16-18)agG>agA	p.R6R	KALRN_ENST00000360013.3_Intron|KALRN_ENST00000428018.2_Silent_p.R6R|KALRN_ENST00000393496.1_Intron	NM_007064.3	NP_008995.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	0					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCGGCGACAGGGCTTACACCC	0.677000													4	7					0	0	1	0	0
WBSCR28	135886	broad.mit.edu	37	7	73279445	73279445	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73279445C>T	ENST00000320531.2	+	2	231	c.195C>T	c.(193-195)ccC>ccT	p.P65P		NM_182504.3	NP_872310.2	Q6UE05	WBS28_HUMAN	Williams-Beuren syndrome chromosome region 28	65						integral to membrane				breast(2)|kidney(2)|lung(6)|skin(1)	11		Lung NSC(55;0.159)				CCCACCTACCCCTGGGAGCTG	0.632000													43	185					0	0	1	0	0
MFAP3L	9848	broad.mit.edu	37	4	170912824	170912824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:170912824G>A	ENST00000361618.3	-	3	1242	c.935C>T	c.(934-936)cCt>cTt	p.P312L	RP11-6E9.4_ENST00000508955.1_RNA|MFAP3L_ENST00000393704.3_Missense_Mutation_p.P209L	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	312						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		AATTTGCTGAGGTTGCTCGTG	0.552000													5	48					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1987498	1987498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:1987498G>A	ENST00000382722.5	-	16	2064	c.1702C>T	c.(1702-1704)Ccc>Tcc	p.P568S	CACNA2D4_ENST00000585708.1_Missense_Mutation_p.P504S|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000586184.1_Missense_Mutation_p.P568S|CACNA2D4_ENST00000585732.1_Missense_Mutation_p.P453S|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.P504S	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	568	Cache.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CGGAGGTCGGGATGGGAGAGG	0.507000													4	6					0	0	1	0	0
TRGV4	6977	broad.mit.edu	37	7	38393601	38393601	+	RNA	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38393601T>A	ENST00000390345.2	-	0	402																											TCGTTCTCCCTTCCAAGTTGG	0.433000													33	76					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862573	14862573	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14862573G>A	ENST00000285046.5	+	1	2105	c.1995G>A	c.(1993-1995)acG>acA	p.T665T	FGD5_ENST00000543601.1_Silent_p.T424T	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	665					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						AGAAGAAGACGGAGAACAAAT	0.512000													9	57					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12122504	12122504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:12122504C>T	ENST00000379388.2	+	4	2808	c.2476C>T	c.(2476-2478)Ctg>Ttg	p.L826L		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	826					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGTGTTTCTTCTGTCTGTACC	0.418000													64	133					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5011861	5011861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5011861C>T	ENST00000380390.1	+	4	570	c.354C>T	c.(352-354)tcC>tcT	p.S118S	MMP26_ENST00000300762.1_Silent_p.S118S			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	118					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGAAGCCATCCGCAGTGAAAG	0.393000													34	66					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48269226	48269226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48269226C>T	ENST00000225964.5	-	31	2168	c.2050G>A	c.(2050-2052)Gag>Aag	p.E684K		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	684	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	ACACCACGCTCGCCAGGGAAA	0.642000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						3	13					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54914569	54914569	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54914569G>A	ENST00000545554.1	+	30	6151	c.6151G>A	c.(6151-6153)Gac>Aac	p.D2051N	UNC13C_ENST00000537900.1_Missense_Mutation_p.D2049N|UNC13C_ENST00000260323.11_Missense_Mutation_p.D2051N|UNC13C_ENST00000539562.2_5'UTR			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2051	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGTTCATGTGGACATCACTGC	0.443000													32	65					0	0	1	0	0
SLC22A16	85413	broad.mit.edu	37	6	110763791	110763791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110763791G>A	ENST00000368919.3	-	4	905	c.839C>T	c.(838-840)cCc>cTc	p.P280L	SLC22A16_ENST00000439654.1_Missense_Mutation_p.P280L|SLC22A16_ENST00000456137.2_3'UTR|SLC22A16_ENST00000330550.4_Missense_Mutation_p.P246L	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	280					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CAGGATAAAGGGGACAGTCAC	0.488000													32	46					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24209511	24209511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24209511G>A	ENST00000265769.4	+	21	2300	c.2190G>A	c.(2188-2190)atG>atA	p.M730I	RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_Missense_Mutation_p.E479K|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	730					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TGAGTCAGATGAAGCCCCATG	0.383000													30	76					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624451	123624451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123624451C>T	ENST00000327930.2	-	1	802	c.776G>A	c.(775-777)aGa>aAa	p.R259K		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGCTGTGGGTCTTAGGTACAT	0.463000													20	68					0	0	1	0	0
CLEC4G	339390	broad.mit.edu	37	19	7796584	7796584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7796584G>A	ENST00000328853.5	-	2	197	c.129C>T	c.(127-129)gtC>gtT	p.V43V	CLEC4G_ENST00000598081.1_5'UTR	NM_001244856.1|NM_198492.3	NP_001231785.1|NP_940894.1	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	43						integral to membrane	protein binding|sugar binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(1)|lung(1)	6						CAGCCCAAAGGACTGTGGTGA	0.607000													19	34					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64622825	64622825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64622825G>A	ENST00000320631.3	-	4	1303	c.1049C>T	c.(1048-1050)cCt>cTt	p.P350L	EHD1_ENST00000359393.2_Missense_Mutation_p.P350L	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	350					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						GAAGTCCCCAGGGGAGATCTG	0.582000											OREG0004024	type=REGULATORY REGION|Gene=EHD1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	25	59					0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50813813	50813813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50813813C>T	ENST00000540145.1	+	9	1791	c.1376C>T	c.(1375-1377)cCc>cTc	p.P459L	CYLD_ENST00000568704.2_Intron|CYLD_ENST00000427738.3_Missense_Mutation_p.P459L|CYLD_ENST00000311559.9_Missense_Mutation_p.P459L|CYLD_ENST00000398568.2_Missense_Mutation_p.P456L|CYLD_ENST00000569418.1_Missense_Mutation_p.P456L|CYLD_ENST00000566206.1_Missense_Mutation_p.P456L|CYLD_ENST00000564326.1_Missense_Mutation_p.P456L			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	459	Interaction with TRAF2.|Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				GAGAGTCCACCCTTGGCCATG	0.512000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				17	87					0	0	1	0	0
SRSF5	6430	broad.mit.edu	37	14	70238135	70238135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70238135C>T	ENST00000553521.1	+	9	2229	c.776C>T	c.(775-777)tCc>tTc	p.S259F	SRSF5_ENST00000553635.1_Missense_Mutation_p.S256F|SRSF5_ENST00000557154.1_Missense_Mutation_p.S259F|SRSF5_ENST00000394366.2_Missense_Mutation_p.S259F|SRSF5_ENST00000556587.1_3'UTR			Q13243	SRSF5_HUMAN	serine/arginine-rich splicing factor 5	259	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding			large_intestine(1)|liver(1)	2						CGCCAGAGGTCCCGGTCCCGA	0.463000													60	151					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53007517	53007517	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53007517G>A	ENST00000305748.3	-	5	973	c.939C>T	c.(937-939)atC>atT	p.I313I	RP11-641A6.2_ENST00000552364.1_RNA|RP11-641A6.2_ENST00000549180.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	313	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTTCCGGGCGATCTCCTCAT	0.597000													33	82					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41795943	41795943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:41795943G>A	ENST00000301831.4	-	22	2693	c.2231C>T	c.(2230-2232)cCc>cTc	p.P744L		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	744							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GCATGTTGAGGGGCTGTCAAG	0.368000													16	83					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95111341	95111341	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95111341G>A	ENST00000469935.1	+	0	1161					NR_015340.1																						AGAACCTGCAGACTGGAGATG	0.502000													15	54					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21263862	21263862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21263862C>T	ENST00000233242.1	-	4	458	c.331G>A	c.(331-333)Gcc>Acc	p.A111T	APOB_ENST00000399256.4_Missense_Mutation_p.A111T	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	111	Heparin-binding.|Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCAGCAAGGCTTTGCCCTCA	0.527000													11	48					0	0	1	0	0
TNIP3	79931	broad.mit.edu	37	4	122075732	122075732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122075732C>T	ENST00000454328.1	-	7	693	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	TNIP3_ENST00000057513.3_Missense_Mutation_p.E156K|TNIP3_ENST00000509841.1_Missense_Mutation_p.E233K|TNIP3_ENST00000507879.1_Missense_Mutation_p.E226K			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	156										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						ATTTCACATTCGTAATGTTCC	0.358000													29	73					0	0	1	0	0
TRA2B	6434	broad.mit.edu	37	3	185638963	185638963	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185638963G>A	ENST00000453386.2	-	6	926	c.651C>T	c.(649-651)cgC>cgT	p.R217R	TRA2B_ENST00000382191.4_Silent_p.R117R	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	217	Linker.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						AATCCCGACGGCGAGAGCTGC	0.418000													25	72					0	0	1	0	0
PAGE4	9506	broad.mit.edu	37	X	49597176	49597176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:49597176G>A	ENST00000218068.6	+	4	294	c.215G>A	c.(214-216)cGg>cAg	p.R72Q	PAGE4_ENST00000376141.1_Missense_Mutation_p.R72Q	NM_007003.2	NP_008934.1	O60829	GAGC1_HUMAN	P antigen family, member 4 (prostate associated)	72												Ovarian(276;0.236)					GAAAAGACTCGGAGTGAGCGT	0.358000													7	30					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045909	87045909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87045909C>T	ENST00000370563.3	+	14	2683	c.2641C>T	c.(2641-2643)Cct>Tct	p.P881S	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	881						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		tacacctactcctactcctac	0.348000													14	48					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72299495	72299495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72299495G>A	ENST00000263563.6	+	15	2153	c.1885G>A	c.(1885-1887)Gac>Aac	p.D629N		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CCCCATGCCGGACTTCTGTGC	0.662000													23	66					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115782979	115782979	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:115782979G>T	ENST00000343348.6	-	19	3210	c.2423C>A	c.(2422-2424)tCc>tAc	p.S808Y	SEMA6A_ENST00000282394.6_Missense_Mutation_p.S285Y|SEMA6A_ENST00000510263.1_Missense_Mutation_p.S808Y|SEMA6A_ENST00000513137.1_Missense_Mutation_p.S235Y|SEMA6A_ENST00000503865.1_Missense_Mutation_p.S187Y|SEMA6A_ENST00000257414.8_Missense_Mutation_p.S825Y	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	808	Pro-rich.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GTGGCTGGGGGAGGCCCGCAG	0.642000													26	64					9.04412e-07	9.06555e-07	1	1	0
CDK5RAP1	51654	broad.mit.edu	37	20	31967359	31967359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31967359G>A	ENST00000357886.4	-	9	1210	c.1057C>T	c.(1057-1059)Cgt>Tgt	p.R353C	CDK5RAP1_ENST00000339269.5_Intron|CDK5RAP1_ENST00000452723.3_Missense_Mutation_p.R249C|CDK5RAP1_ENST00000544843.1_Missense_Mutation_p.R339C|CDK5RAP1_ENST00000346416.2_Missense_Mutation_p.R339C|CDK5RAP1_ENST00000473997.1_5'UTR			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	353					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity	p.R339C(1)		endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						TGAGCAAAACGAAGTCCTCCT	0.483000													23	39					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122854132	122854132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122854132G>A	ENST00000264811.5	-	1	480	c.62C>T	c.(61-63)gCt>gTt	p.A21V	TRPC3_ENST00000379645.3_Missense_Mutation_p.A94V|TRPC3_ENST00000513531.1_Missense_Mutation_p.A21V	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	9					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCCCCTGACAGCCTGGCGCCG	0.607000													7	50					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49736512	49736512	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49736512C>T	ENST00000327697.6	+	10	882	c.738C>T	c.(736-738)gcC>gcT	p.A246A	RNF123_ENST00000432042.1_Silent_p.A100A	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	246	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		AGTCCGTGGCCTTCAACTTTG	0.582000													29	97					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34863731	34863731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34863731G>A	ENST00000431794.3	-	15	1786	c.1264C>T	c.(1264-1266)Cct>Tct	p.P422S	MYO19_ENST00000268852.9_Missense_Mutation_p.P422S	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	422	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGTTGTCAGGAAATGATTCA	0.537000													7	28					0	0	1	0	0
SYNGR1	9145	broad.mit.edu	37	22	39773623	39773623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39773623C>T	ENST00000318801.4	+	4	590	c.504C>T	c.(502-504)gcC>gcT	p.A168A	SYNGR1_ENST00000381535.4_Silent_p.A169A|SYNGR1_ENST00000328933.5_Intron	NM_145731.3	NP_663783.1			synaptogyrin 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	7	Melanoma(58;0.04)					CAGCCCTGGCCGTGCGGAGAT	0.672000													7	27					0	0	1	0	0
MANBA	4126	broad.mit.edu	37	4	103592516	103592516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:103592516C>T	ENST00000226578.4	-	9	1251	c.1152G>A	c.(1150-1152)atG>atA	p.M384I	MANBA_ENST00000505239.1_Missense_Mutation_p.M327I	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	384					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		GAAGAGTATTCATATTAGCAT	0.353000													18	35					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540249	169540249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169540249C>T	ENST00000340806.6	+	1	540	c.540C>T	c.(538-540)ttC>ttT	p.F180F		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	180										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						TTGAAGTTTTCCCCCAGGAGC	0.517000													34	86					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9021059	9021059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9021059C>T	ENST00000397910.4	-	19	37467	c.37264G>A	c.(37264-37266)Ggt>Agt	p.G12422S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12424	SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCACCAGACCCTGCAGGACC	0.547000													29	129					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119583407	119583407	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119583407G>A	ENST00000267260.4	+	9	1381	c.993G>A	c.(991-993)ggG>ggA	p.G331G		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	331	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding	p.G331fs*37(2)		breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						CTGATTCAGGGAACTCCTTCA	0.612000													4	20					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48370691	48370691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48370691G>A	ENST00000395702.2	+	2	386	c.159G>A	c.(157-159)acG>acA	p.T53T	ZNF488_ENST00000494156.1_Silent_p.T53T|ZNF488_ENST00000586537.1_5'UTR			Q96MN9	ZN488_HUMAN	zinc finger protein 488	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						TCGAGAAGACGAACCGCCTGG	0.677000													25	59					0	0	1	0	0
LY6K	54742	broad.mit.edu	37	8	143783057	143783057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143783057G>A	ENST00000522591.1	+	2	199	c.143G>A	c.(142-144)aGa>aAa	p.R48K	LY6K_ENST00000292430.6_Missense_Mutation_p.R48K|LY6K_ENST00000519387.1_Missense_Mutation_p.R48K|LY6K_ENST00000518841.1_Missense_Mutation_p.R48K|LY6K_ENST00000561179.1_Missense_Mutation_p.R106K|LY6K_ENST00000519390.1_3'UTR			Q17RY6	LY6K_HUMAN	lymphocyte antigen 6 complex, locus K	48	UPAR/Ly6.					anchored to membrane|cytoplasm|extracellular region|nucleolus|plasma membrane				NS(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)	10	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GTTTGTGAGAGAGAAAACACT	0.473000													9	43					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226910	24226910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24226910C>T	ENST00000345044.6	+	12	1633	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	SLC2A11_ENST00000316185.8_Silent_p.F458F|AP000350.10_ENST00000433835.3_Intron|SLC2A11_ENST00000398356.2_Silent_p.F462F			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	455						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						CTGGCCTGTTCCTTCCTGAGA	0.562000													51	144					0	0	1	0	0
B3GNT7	93010	broad.mit.edu	37	2	232263400	232263400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:232263400C>T	ENST00000287590.5	+	2	1231	c.970C>T	c.(970-972)Ccg>Tcg	p.P324S		NM_145236.2	NP_660279.1	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	324					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)	17		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		GGAGCTCTACCCGATCGACGA	0.672000													9	53					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070414	114070414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:114070414G>A	ENST00000462705.1	-	11	1113	c.292C>T	c.(292-294)Ctg>Ttg	p.L98L	ZBTB20_ENST00000464560.1_Silent_p.L98L|ZBTB20_ENST00000481632.1_Silent_p.L98L|ZBTB20_ENST00000471418.1_Silent_p.L98L|ZBTB20_ENST00000474710.1_Silent_p.L171L|ZBTB20_ENST00000393785.2_Silent_p.L98L|ZBTB20_ENST00000357258.3_Silent_p.L98L	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		AGGATCTGCAGAGCTTCCGAC	0.582000													29	42					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936471	4936471	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4936471G>A	ENST00000322013.3	-	1	451	c.423C>T	c.(421-423)ctC>ctT	p.L141L	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTGTTGGTGAGAATGGAAA	0.478000													12	52					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323156	61323156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61323156C>T	ENST00000283752.5	-	8	1051	c.908G>A	c.(907-909)gGa>gAa	p.G303E	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.G251E	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	303					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						ATCCACCATTCCCATGGTTCT	0.502000													27	121					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94173221	94173221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94173221G>A	ENST00000553484.1	+	51	8099	c.7945G>A	c.(7945-7947)Gaa>Aaa	p.E2649K	UNC79_ENST00000555664.1_Missense_Mutation_p.E2588K|UNC79_ENST00000256339.4_Missense_Mutation_p.E2450K|UNC79_ENST00000393151.2_Missense_Mutation_p.E2627K			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2627						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCAGTCCTCGGAAGCAGCCTC	0.527000													20	66					0	0	1	0	0
MVP	9961	broad.mit.edu	37	16	29856066	29856066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29856066C>T	ENST00000357402.5	+	11	2025	c.1887C>T	c.(1885-1887)ccC>ccT	p.P629P	MVP_ENST00000395353.1_Silent_p.P629P	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	629					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						CTGTCTTCCCCCAAAACGGGC	0.657000													13	145					0	0	1	0	0
ZNF563	147837	broad.mit.edu	37	19	12429458	12429458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12429458G>A	ENST00000293725.5	-	4	1586	c.1381C>T	c.(1381-1383)Ccc>Tcc	p.P461S		NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						CATACACTGGGATAAACAAAG	0.378000													52	109					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32742026	32742026	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32742026T>G	ENST00000333070.4	+	8	820	c.720T>G	c.(718-720)gtT>gtG	p.V240V	LCK_ENST00000373564.3_Intron|LCK_ENST00000336890.5_Silent_p.V240V	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	240	Interaction with PTPRH.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	AGTGGGAGGTTCCCAGGGAGA	0.662000			T	TRB@	T-ALL								13	37					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56949917	56949917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56949917C>T	ENST00000497933.1	+	1	697	c.550C>T	c.(550-552)Cac>Tac	p.H184Y		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	154						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						TGGGCTAGTCCACATCGACCT	0.607000													16	34					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105153049	105153049	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105153049G>A	ENST00000428173.2	+	13	1722	c.1419G>A	c.(1417-1419)cgG>cgA	p.R473R	NRK_ENST00000243300.9_Silent_p.R472R			Q7Z2Y5	NRK_HUMAN	Nik related kinase	472	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						CACGACTACGGAGGGCAGCCA	0.562000										HNSCC(51;0.14)			11	18					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201016711	201016711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201016711C>T	ENST00000362061.3	-	37	4711	c.4485G>A	c.(4483-4485)aaG>aaA	p.K1495K	CACNA1S_ENST00000367338.3_Silent_p.K1476K	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1495					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCCAGATCTTCTTGATGATGG	0.527000													18	58					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16021577	16021577	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16021577G>A	ENST00000350896.3	-	5	1011	c.814C>T	c.(814-816)Caa>Taa	p.Q272*	MSR1_ENST00000381998.4_Nonsense_Mutation_p.Q272*|MSR1_ENST00000536385.1_Nonsense_Mutation_p.Q46*|MSR1_ENST00000262101.5_Nonsense_Mutation_p.Q272*|MSR1_ENST00000445506.2_Nonsense_Mutation_p.Q290*|MSR1_ENST00000355282.2_Nonsense_Mutation_p.Q272*	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	272					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTTTACCTTGAATTAAAGTG	0.294000													15	33					0	0	1	0	0
FPGS	2356	broad.mit.edu	37	9	130569509	130569509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130569509C>T	ENST00000373245.1	+	6	573	c.523C>T	c.(523-525)Ccc>Tcc	p.P175S	FPGS_ENST00000373225.3_Missense_Mutation_p.P125S|FPGS_ENST00000460181.1_3'UTR|FPGS_ENST00000393706.2_Intron|FPGS_ENST00000373247.2_Missense_Mutation_p.P175S			Q05932	FOLC_HUMAN	folylpolyglutamate synthase	175					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7					L-Glutamic Acid(DB00142)	TGTCTCCATGCCCCCCTACTT	0.602000													41	109					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29879498	29879498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29879498G>A	ENST00000310624.6	+	2	1051	c.1018G>A	c.(1018-1020)Gac>Aac	p.D340N		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	340	Coil 2B.|Rod.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						AAGCACCAAGGACTCACTGGA	0.612000													26	102					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152394450	152394450	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152394450C>T	ENST00000427231.2	-	140	21240	c.21038G>A	c.(21037-21039)tGg>tAg	p.W7013*	NEB_ENST00000604864.1_Nonsense_Mutation_p.W7013*|NEB_ENST00000603639.1_Nonsense_Mutation_p.W7013*|NEB_ENST00000172853.10_Nonsense_Mutation_p.W5312*|NEB_ENST00000397345.3_Nonsense_Mutation_p.W7013*|NEB_ENST00000409198.1_Nonsense_Mutation_p.W5312*	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	5312					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AATGGACCTCCAGATACCCAA	0.393000													12	38					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86468627	86468627	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:86468627G>A	ENST00000297814.2	-	15	3417	c.3274C>T	c.(3274-3276)Cgt>Tgt	p.R1092C	RP11-575L7.4_ENST00000590813.1_RNA|RP11-575L7.4_ENST00000586206.1_RNA|RP11-575L7.4_ENST00000590368.1_RNA|RP11-575L7.4_ENST00000591217.1_RNA|KIF27_ENST00000334204.2_Missense_Mutation_p.R995C|KIF27_ENST00000413982.1_Missense_Mutation_p.R1026C|RP11-575L7.4_ENST00000589817.1_RNA	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	1092					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						GCTTCACCACGAGAGAGGTTA	0.398000													37	90					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131220670	131220670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:131220670C>T	ENST00000337057.3	-	8	1378	c.1197G>A	c.(1195-1197)aaG>aaA	p.K399K	EPB41L2_ENST00000525271.1_Silent_p.K399K|EPB41L2_ENST00000528282.1_Silent_p.K399K|EPB41L2_ENST00000525193.1_Silent_p.K399K|EPB41L2_ENST00000527659.1_Silent_p.K399K|EPB41L2_ENST00000392427.3_Silent_p.K399K|EPB41L2_ENST00000445890.2_Silent_p.K399K|EPB41L2_ENST00000368128.2_Silent_p.K399K|EPB41L2_ENST00000527411.1_Silent_p.K399K|EPB41L2_ENST00000530481.1_Silent_p.K399K|EPB41L2_ENST00000530148.1_5'UTR|EPB41L2_ENST00000529208.1_Silent_p.K399K	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	399	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TGGAAAGCCTCTTTGCATTTT	0.418000													34	63					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31146148	31146148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31146148G>A	ENST00000304166.4	+	16	1546	c.1257G>A	c.(1255-1257)aaG>aaA	p.K419K	ADCYAP1R1_ENST00000409363.1_Silent_p.K398K|ADCYAP1R1_ENST00000409489.1_Silent_p.K475K|ADCYAP1R1_ENST00000396211.2_Silent_p.K447K	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	419					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						GAAGCTGGAAGGTGAACCGTT	0.592000													25	49					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77274304	77274304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77274304G>A	ENST00000251089.2	-	3	949	c.837C>T	c.(835-837)ttC>ttT	p.F279F		NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	279										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TGAGGTTCACGAAGCGATAGT	0.512000													22	57					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770263	53770263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53770263C>T	ENST00000311170.4	-	1	709	c.656G>A	c.(655-657)aGc>aAc	p.S219N		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	219					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GGAGAGATTGCTCCTATCAAT	0.547000										HNSCC(26;0.072)			9	26					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32221810	32221810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32221810G>A	ENST00000373658.3	-	4	969	c.628C>T	c.(628-630)Cgc>Tgc	p.R210C	BAI2_ENST00000398556.3_Missense_Mutation_p.R213C|BAI2_ENST00000257070.4_Missense_Mutation_p.R210C|BAI2_ENST00000398538.1_Missense_Mutation_p.R198C|BAI2_ENST00000527361.1_Missense_Mutation_p.R210C|BAI2_ENST00000398542.1_Missense_Mutation_p.R198C|BAI2_ENST00000398547.1_Missense_Mutation_p.R198C|BAI2_ENST00000373655.2_Missense_Mutation_p.R210C	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	210					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CCGGCAGCGCGGCCACACTCC	0.647000													7	51					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814507	60814507	+	Missense_Mutation	SNP	C	C	T	rs17853369		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60814507C>T	ENST00000544856.2	-	7	1097	c.719G>A	c.(718-720)gGa>gAa	p.G240E	MARCH10_ENST00000583600.1_Missense_Mutation_p.G279E|RP11-156L14.1_ENST00000577270.1_RNA|RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.G241E|MARCH10_ENST00000311269.5_Missense_Mutation_p.G241E			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	241							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						ACTATTTTTTCCTTGGAAGGC	0.532000													48	127					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23225854	23225854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:23225854G>A	ENST00000389131.3	-	2	380	c.11C>T	c.(10-12)cCt>cTt	p.P4L		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	4					aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GGAGCACAGAGGCCTCTCCAT	0.637000													22	31					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61834025	61834025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61834025G>A	ENST00000280772.1	-	37	6805	c.6614C>T	c.(6613-6615)cCa>cTa	p.P2205L	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2205					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGTGGGCTTTGGTTCCAATTC	0.448000													33	94					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96030073	96030073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96030073G>A	ENST00000297954.4	+	16	3742	c.3742G>A	c.(3742-3744)Gag>Aag	p.E1248K	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.E860K|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.E860K|WNK2_ENST00000395477.2_Missense_Mutation_p.E1248K			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1248					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						AACGTTCATCGAGCAGATGAA	0.602000													4	18					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101918575	101918575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101918575C>T	ENST00000437600.4	+	17	1854	c.1502C>T	c.(1501-1503)tCc>tTc	p.S501F	CUX1_ENST00000425244.2_Missense_Mutation_p.S457F|CUX1_ENST00000393824.3_Missense_Mutation_p.S464F|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000292538.4_Missense_Mutation_p.S503F|CUX1_ENST00000547394.2_Missense_Mutation_p.S487F	NM_181500.2	NP_852477.1	P39880	CUX1_HUMAN	cut-like homeobox 1	315					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCACTGCTTTCCATCATCTCC	0.642000													30	72					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70928354	70928354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70928354G>A	ENST00000393567.2	-	55	9396	c.9246C>T	c.(9244-9246)ttC>ttT	p.F3082F		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3082										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CCAGTTACCTGAACGCGATCT	0.522000													12	46					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128362842	128362842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:128362842C>T	ENST00000262462.4	+	7	2282	c.1272C>T	c.(1270-1272)ctC>ctT	p.L424L	SLC27A6_ENST00000506176.1_Silent_p.L424L|SLC27A6_ENST00000395266.1_Silent_p.L424L			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	424					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CTGGACTTCTCATTTCTCGAG	0.378000													40	92					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149906993	149906993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149906993G>A	ENST00000439741.2	-	5	604	c.354C>T	c.(352-354)ctC>ctT	p.L118L	MTMR11_ENST00000406732.3_Silent_p.L90L|MTMR11_ENST00000369140.3_Silent_p.L46L|MTMR11_ENST00000361405.6_Silent_p.L118L|MTMR11_ENST00000492824.1_5'UTR	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	118							phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACCCTGGACGGAGGAGCTGGA	0.547000													28	87					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107844633	107844633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107844633G>A	ENST00000328300.6	+	26	2203	c.1959G>A	c.(1957-1959)ggG>ggA	p.G653G	COL4A5_ENST00000361603.2_Silent_p.G653G	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	653	Triple-helical region.		G -> R (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GTCCTAAAGGGGATCCAGGTC	0.403000									Alport syndrome with Diffuse Leiomyomatosis				9	13					0	0	1	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473075	22473075	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22473075C>T	ENST00000557788.2	-	0	195																											CCAATCCACTCCAGCCCCTTC	0.572000													26	233					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158746637	158746637	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158746637C>T	ENST00000339258.1	-	1	788	c.789G>A	c.(787-789)aaG>aaA	p.K263K		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					AATAGCTCTTCTTTAGCCGCA	0.443000													37	77					0	0	1	0	0
NFAM1	150372	broad.mit.edu	37	22	42807591	42807591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42807591C>T	ENST00000329021.5	-	2	310	c.273G>A	c.(271-273)agG>agA	p.R91R		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	91	Ig-like V-type.				B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			large_intestine(1)|lung(3)	4						TCTTAGGGCTCCTCTGTCCCT	0.547000													34	86					0	0	1	0	0
ZRANB2	9406	broad.mit.edu	37	1	71530793	71530793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:71530793G>A	ENST00000370920.3	-	10	1258	c.957C>T	c.(955-957)tcC>tcT	p.S319S	ZRANB2-AS1_ENST00000450461.1_RNA|ZRANB2_ENST00000254821.6_3'UTR|ZRANB2-AS1_ENST00000426999.1_RNA|ZRANB2_ENST00000477096.1_5'UTR	NM_203350.2	NP_976225.1	O95218	ZRAB2_HUMAN	zinc finger, RAN-binding domain containing 2	319	Required for nuclear targeting.				mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|stomach(1)	15						AACCAGAATGGGATGATCCAG	0.348000													7	61					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73464772	73464772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73464772G>A	ENST00000224721.6	+	24	2858	c.2853G>A	c.(2851-2853)gtG>gtA	p.V951V	CDH23_ENST00000299366.7_Silent_p.V991V	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	946	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCAGCGGCGTGGTGGTCACCA	0.667000													39	85					0	0	1	0	0
ECSIT	51295	broad.mit.edu	37	19	11624842	11624842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11624842C>T	ENST00000270517.7	-	3	426	c.291G>A	c.(289-291)gcG>gcA	p.A97A	ECSIT_ENST00000252440.7_Silent_p.A97A|ECSIT_ENST00000591104.1_Silent_p.A97A|ECSIT_ENST00000592312.1_5'UTR|ECSIT_ENST00000417981.2_Intron|ECSIT_ENST00000588998.1_Intron	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	97					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						CGCTGTGCTCCGCAAATTTCT	0.622000													18	58					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76573651	76573651	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:76573651C>T	ENST00000307431.8	+	21	3638	c.3253C>T	c.(3253-3255)Caa>Taa	p.Q1085*	CNTNAP4_ENST00000478060.1_Nonsense_Mutation_p.Q1013*|CNTNAP4_ENST00000377504.4_Nonsense_Mutation_p.Q1037*|CNTNAP4_ENST00000476707.1_Nonsense_Mutation_p.Q1089*|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1086	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AAATAAATATCAAGAGCCTGA	0.343000													22	40					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56190114	56190114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56190114C>T	ENST00000340462.4	-	3	542	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	ZBP1_ENST00000371173.3_Missense_Mutation_p.E111K|ZBP1_ENST00000395822.3_Missense_Mutation_p.E36K|ZBP1_ENST00000538947.1_5'UTR|ZBP1_ENST00000541799.1_Missense_Mutation_p.E111K|ZBP1_ENST00000343535.4_Missense_Mutation_p.E111K			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	111			E -> K (in dbSNP:rs2073145).			cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			TAGATGTCTTCCTCTGGgagg	0.572000													28	136					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137681046	137681046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137681046G>A	ENST00000371817.3	+	32	3106	c.2692G>A	c.(2692-2694)Ggc>Agc	p.G898S		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	898	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGGAGAGAAGGGCGGCAGGGT	0.572000													15	22					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14766126	14766126	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14766126C>T	ENST00000261170.3	-	27	3283	c.3147G>A	c.(3145-3147)cgG>cgA	p.R1049R	RP11-695J4.2_ENST00000542401.1_RNA|RP11-695J4.2_ENST00000545424.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	1049					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AGCTGGCTACCCGTCTGGGTT	0.433000													68	250					0	0	1	0	0
GGTLC2	91227	broad.mit.edu	37	22	22989517	22989517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22989517G>A	ENST00000448514.1	+	3	369	c.369G>A	c.(367-369)atG>atA	p.M123I	GGTLC2_ENST00000480559.1_Intron			Q14390	GGTL2_HUMAN	gamma-glutamyltransferase light chain 2	120					glutathione biosynthetic process		gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		AGGTCCGGATGGTGGTGGGAG	0.642000													30	90					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390859	197390859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197390859C>T	ENST00000367397.1	+	2	902	c.44C>T	c.(43-45)cCa>cTa	p.P15L	CRB1_ENST00000544212.1_Missense_Mutation_p.P115L|CRB1_ENST00000538660.1_Missense_Mutation_p.P634L|CRB1_ENST00000367399.2_Missense_Mutation_p.P522L|CRB1_ENST00000543483.1_Intron|CRB1_ENST00000535699.1_Missense_Mutation_p.P565L|CRB1_ENST00000367400.3_Missense_Mutation_p.P634L			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	634					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TATAATATGCCATCCACACCT	0.408000													54	149					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43579536	43579536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43579536G>A	ENST00000406487.1	-	3	777	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	227	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region		p.R227C(1)		central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GGGTCACTGCGGCTGGCACTC	0.527000													39	447					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76463724	76463724	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:76463724C>T	ENST00000396423.2	+	4	578	c.454C>T	c.(454-456)Cgc>Tgc	p.R152C	HNF4G_ENST00000354370.1_Missense_Mutation_p.R115C	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	115					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			AGTTCGGTCTCGCCAGGTACC	0.423000													9	34					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49699167	49699167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49699167G>A	ENST00000296452.4	+	6	10003	c.9889G>A	c.(9889-9891)Gat>Aat	p.D3297N		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3297					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGACTCATACGATCCCCGCGG	0.612000													23	58					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676400	65676400	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65676400G>A	ENST00000352385.2	-	20	3909	c.3700C>T	c.(3700-3702)Cct>Tct	p.P1234S	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1234						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GCTCCTAGAGGGCAGGGGGAT	0.632000													7	24					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23872985	23872985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23872985C>T	ENST00000405093.3	-	9	808	c.738G>A	c.(736-738)ggG>ggA	p.G246G	MYH6_ENST00000356287.3_Silent_p.G246G	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	246	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TAATGAATTTCCCCTGGGGAC	0.567000													6	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179529611	179529611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179529611G>A	ENST00000589042.1	-	166	36310	c.36086C>T	c.(36085-36087)cCt>cTt	p.P12029L	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10177	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTTGGAAGGAACTGTCTT	0.373000													5	22					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814126	123814126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123814126G>A	ENST00000321252.2	-	1	454	c.420C>T	c.(418-420)gtC>gtT	p.V140V		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V140V(1)		breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTTGGGAACAGACATGGCCAT	0.567000													12	18					0	0	1	0	0
KCNIP3	30818	broad.mit.edu	37	2	96040113	96040113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96040113C>T	ENST00000295225.5	+	3	386	c.251C>T	c.(250-252)gCc>gTc	p.A84V	KCNIP3_ENST00000360990.3_Missense_Mutation_p.A84V|KCNIP3_ENST00000468529.1_Missense_Mutation_p.A58V|KCNIP3_ENST00000377181.2_3'UTR	NM_013434.4	NP_038462.1	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3, calsenilin	84	EF-hand 1; degenerate.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	16				READ - Rectum adenocarcinoma(193;0.13)		CAGCTGCAGGCCCAGACCAAG	0.602000													16	58					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18524140	18524140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18524140C>T	ENST00000433979.1	+	12	1768	c.1652C>T	c.(1651-1653)tCa>tTa	p.S551L	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.S551L|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.S592L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	551					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GAAATAAAGTCACTTCCAAGG	0.368000													8	18					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22892237	22892237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22892237G>A	ENST00000543184.1	-	4	1726	c.864C>T	c.(862-864)ttC>ttT	p.F288F	PRAME_ENST00000398743.2_Silent_p.F288F|PRAME_ENST00000402697.1_Silent_p.F288F|PRAME_ENST00000398741.1_Silent_p.F288F|PRAME_ENST00000405655.3_Silent_p.F288F|PRAME_ENST00000539862.1_Silent_p.F272F|PRAME_ENST00000424204.2_Silent_p.F272F	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	288					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		ACTGAGAGGTGAACTGGGCGA	0.522000													27	66					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28519449	28519449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28519449G>A	ENST00000261609.7	-	7	896	c.788C>T	c.(787-789)tCc>tTc	p.S263F		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	263					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGTCACGACGGACCTGAGGAA	0.592000													14	28					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7708370	7708370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7708370C>T	ENST00000572933.1	+	60	10738	c.9278C>T	c.(9277-9279)cCc>cTc	p.P3093L	DNAH2_ENST00000389173.2_Missense_Mutation_p.P3093L			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3093	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GAGGCACTGCCCGCCCTGGAA	0.587000													45	48					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95403849	95403849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95403849G>A	ENST00000336148.5	-	10	1921	c.1797C>T	c.(1795-1797)ttC>ttT	p.F599F		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			TTATAGAGTTGAACAAAAGGC	0.408000								Direct reversal of damage;Homologous recombination					58	136					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234452365	234452365	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:234452365C>T	ENST00000366618.3	+	5	991	c.846C>T	c.(844-846)ctC>ctT	p.L282L	SLC35F3_ENST00000366617.3_Silent_p.L213L	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	213					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CCGCCATCCTCGCCATCGCTG	0.577000													148	370					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724972	49724972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49724972C>T	ENST00000551245.1	+	13	2455	c.2344C>T	c.(2344-2346)Cct>Tct	p.P782S	TROAP_ENST00000257909.3_Intron|TROAP_ENST00000547923.1_Intron			Q12815	TROAP_HUMAN	trophinin associated protein	0					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						CCCAGACCTCCCTCTAAATTT	0.582000													12	27					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91809811	91809811	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91809811G>A	ENST00000394232.1	+	7	1478		c.e7-1		SV2B_ENST00000545111.2_Splice_Site|SV2B_ENST00000330276.4_Splice_Site	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B						neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTACTTTTCAGGTTTCCAACA	0.373000													18	69					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619434	57619434	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57619434C>T	ENST00000349394.5	+	2	1006	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	277	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						TCAAAGTCATCTGTATCTTCG	0.572000													16	68					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156882382	156882382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156882382C>T	ENST00000338302.3	+	18	2402	c.2177C>T	c.(2176-2178)cCc>cTc	p.P726L	PEAR1_ENST00000292357.7_Missense_Mutation_p.P726L			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	726						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGTGTATGTCCCCCAGGGCAC	0.602000													21	55					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36845839	36845839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36845839G>A	ENST00000279024.4	-	13	2988	c.2717C>T	c.(2716-2718)gCc>gTc	p.A906V		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	906										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CAGCTGAGCGGCCTGCTTGGA	0.692000													8	19					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182852338	182852338	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:182852338C>T	ENST00000367549.3	+	25	3089	c.2979C>T	c.(2977-2979)tcC>tcT	p.S993S	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	993					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						TTGTTATCTCCCTCCTGGCCT	0.398000													38	113					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70455136	70455136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70455136G>A	ENST00000503640.1	-	6	1593	c.1538C>T	c.(1537-1539)tCc>tTc	p.S513F	UGT2A1_ENST00000286604.4_Missense_Mutation_p.S513F|UGT2A1_ENST00000512704.1_Missense_Mutation_p.S469F|UGT2A1_ENST00000514019.1_Missense_Mutation_p.S679F|UGT2A2_ENST00000457664.2_Missense_Mutation_p.S522F	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	513					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						TTTTTGACAGGAAAACAAACA	0.353000													23	62					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186459360	186459360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186459360G>A	ENST00000265023.4	+	10	1387	c.1175G>A	c.(1174-1176)cGa>cAa	p.R392Q	RP11-573D15.8_ENST00000354642.2_RNA|RP11-573D15.8_ENST00000599314.1_RNA|KNG1_ENST00000447445.1_Missense_Mutation_p.R356Q|KNG1_ENST00000287611.2_Missense_Mutation_p.R392Q	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	392					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CGATCATCACGAATAGGGGAA	0.403000													18	105					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89941791	89941791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89941791G>A	ENST00000405460.2	+	16	3001	c.2905G>A	c.(2905-2907)Gaa>Aaa	p.E969K		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	969	Calx-beta 7.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAAGATTCCAGAAGAAATGGA	0.323000													9	32					0	0	1	0	0
ASF1B	55723	broad.mit.edu	37	19	14247214	14247214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14247214G>A	ENST00000263382.3	-	1	554	c.55C>T	c.(55-57)Cac>Tac	p.H19Y	ASF1B_ENST00000592798.1_Missense_Mutation_p.H19Y|ASF1B_ENST00000474890.1_Missense_Mutation_p.H19Y	NM_018154.2	NP_060624.1	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B histone chaperone	19	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus				endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7						AAGGGGCTGTGGAAAGGGCTC	0.716000													13	43					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024477	55024477	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:55024477C>T	ENST00000324000.3	+	3	2670	c.636C>T	c.(634-636)ccC>ccT	p.P212P		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	212					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CCTTCAACCCCAGCATCCTGG	0.398000													31	103					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43310378	43310378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43310378C>T	ENST00000321925.4	+	3	325	c.93C>T	c.(91-93)ttC>ttT	p.F31F	SLC14A1_ENST00000586142.1_Silent_p.F31F|SLC14A1_ENST00000502059.2_Intron|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000436407.3_Silent_p.F87F|SLC14A1_ENST00000415427.3_Silent_p.F87F|SLC14A1_ENST00000535474.1_Intron|SLC14A1_ENST00000402943.2_Intron|SLC14A1_ENST00000589700.1_Silent_p.F31F|SLC14A1_ENST00000591943.1_3'UTR	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	31						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						GAAGGTGCTTCCCCAAAGCTC	0.488000													32	84					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481842	140481842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140481842G>A	ENST00000231130.2	+	1	1609	c.1609G>A	c.(1609-1611)Ggc>Agc	p.G537S		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		537	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACAGACCGTGGCTCCCCGGC	0.677000													36	93					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86270675	86270675	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86270675C>T	ENST00000394518.2	+	29	7163	c.7068C>T	c.(7066-7068)acC>acT	p.T2356T	AKAP13_ENST00000394510.2_Silent_p.T601T|AKAP13_ENST00000361243.2_Silent_p.T2360T|AKAP13_ENST00000560579.1_3'UTR	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2356	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TGTTGGACACCAGAGCCCGAG	0.438000													21	93					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219874711	219874711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219874711C>T	ENST00000341552.5	-	27	4488	c.4405G>A	c.(4405-4407)Gag>Aag	p.E1469K	CCDC108_ENST00000453220.1_Missense_Mutation_p.E1469K|AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000441968.1_Missense_Mutation_p.E1469K	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1469						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAATTTCCTCGTTCTTGGAG	0.532000													11	48					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77779516	77779516	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:77779516G>A	ENST00000407578.2	-	26	3984	c.3718C>T	c.(3718-3720)Cat>Tat	p.H1240Y	MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Missense_Mutation_p.H1202Y|MYCBP2_ENST00000544440.2_Missense_Mutation_p.H1202Y	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CCTCCTCCATGACCTAGAATA	0.368000													31	63					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90498113	90498113	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90498113G>A	ENST00000325643.5	+	1	373	c.307G>A	c.(307-309)Gag>Aag	p.E103K		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GAGCAGCAGGGAGGTAAGGAG	0.557000													4	7					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42457418	42457418	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42457418G>A	ENST00000381668.5	-	29	2944	c.2713C>T	c.(2713-2715)Cct>Tct	p.P905S	ATP8A1_ENST00000264449.10_Missense_Mutation_p.P890S	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	905					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	AGAGTTAAAGGAGGCATTGCT	0.398000													31	92					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286638	152286638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152286638C>T	ENST00000368799.1	-	3	759	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	242					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCATAGGCTTCATCCTGGATT	0.353000									Ichthyosis				46	123					0	0	1	0	0
ATF2	1386	broad.mit.edu	37	2	175939542	175939542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:175939542G>A	ENST00000264110.2	-	14	1611	c.1313C>T	c.(1312-1314)tCa>tTa	p.S438L	ATF2_ENST00000345739.5_Missense_Mutation_p.S380L|ATF2_ENST00000538946.1_3'UTR|ATF2_ENST00000409635.1_Missense_Mutation_p.S380L|ATF2_ENST00000392544.1_Missense_Mutation_p.S438L|ATF2_ENST00000487334.2_3'UTR|ATF2_ENST00000392543.2_Missense_Mutation_p.S59L|ATF2_ENST00000409499.1_Missense_Mutation_p.S77L|ATF2_ENST00000426833.3_Missense_Mutation_p.S420L|ATF2_ENST00000409437.1_Missense_Mutation_p.S322L	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	438					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			AATGTCTTCTGAACTATCATC	0.418000													17	52					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138713428	138713428	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138713428G>A	ENST00000389532.4	-	11	3143	c.3079C>T	c.(3079-3081)Ctt>Ttt	p.L1027F	CAMSAP1_ENST00000312405.6_Missense_Mutation_p.L749F|CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.L1038F	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	1027						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GTTTCGTTAAGCTTCTCGATG	0.542000													18	34					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433090	55433090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55433090G>A	ENST00000314259.3	+	1	477	c.448G>A	c.(448-450)Gga>Aga	p.G150R		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TTGGGTGGGGGGATTTATGCA	0.468000													21	94					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175334383	175334383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175334383G>A	ENST00000367674.1	-	12	3058	c.2350C>T	c.(2350-2352)Cat>Tat	p.H784Y	TNR_ENST00000263525.2_Missense_Mutation_p.H784Y	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	784	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GAGGTCACATGAGAAAAGTGC	0.507000													16	32					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497337	141497337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141497337C>T	ENST00000264952.2	+	1	348	c.211C>T	c.(211-213)Cgt>Tgt	p.R71C		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	71	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CCGCCTCTTCCGTGACTTCCT	0.662000													15	22					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1684132	1684132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1684132C>T	ENST00000252804.4	-	7	613	c.563G>A	c.(562-564)cGa>cAa	p.R188Q		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	188					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TGAGTCCAGTCGCCTGTGGGA	0.592000													16	32					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104432603	104432603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:104432603C>T	ENST00000297579.5	+	2	915	c.638C>T	c.(637-639)tCg>tTg	p.S213L	DCAF13_ENST00000521716.1_Missense_Mutation_p.S57L|DCAF13_ENST00000519682.1_Missense_Mutation_p.S57L|DCAF13_ENST00000521999.1_Intron|DCAF13_ENST00000521971.1_Missense_Mutation_p.S57L	NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	61					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						TTCCTTGCTTCGCTGGATGGT	0.458000													23	45					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76752151	76752151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76752151G>A	ENST00000575389.2	+	2	160	c.160G>A	c.(160-162)Gag>Aag	p.E54K	SALL3_ENST00000537592.2_Missense_Mutation_p.E54K|SALL3_ENST00000536229.3_5'UTR|SALL3_ENST00000572928.1_3'UTR			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CAGCGTGTGCGAGAAATGCTG	0.687000													5	18					0	0	1	0	0
OR1J1	347168	broad.mit.edu	37	9	125239244	125239244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125239244C>T	ENST00000259357.2	-	1	991	c.962G>A	c.(961-963)gGa>gAa	p.G321E		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	321					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						gcctcagcctcccaaagtgtt	0.468000													13	33					0	0	1	0	0
C2orf42	54980	broad.mit.edu	37	2	70387902	70387902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70387902G>A	ENST00000264434.2	-	9	1750	c.1371C>T	c.(1369-1371)acC>acT	p.T457T	C2orf42_ENST00000420306.1_Silent_p.T457T	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	457										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						TAAAGCTACGGGTGATTTCCA	0.403000													17	45					0	0	1	0	0
H2BFM	286436	broad.mit.edu	37	X	103294884	103294884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:103294884C>T	ENST00000243297.5	+	3	650	c.650C>T	c.(649-651)tCc>tTc	p.S217F	H2BFM_ENST00000355016.3_Missense_Mutation_p.S114F					H2B histone family, member M											endometrium(1)|lung(1)|ovary(1)	3						ACCATCACCTCCCGGGACATC	0.617000													5	5					0	0	1	0	0
PPP6R1	22870	broad.mit.edu	37	19	55750817	55750817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55750817G>A	ENST00000412770.2	-	15	2273	c.1707C>T	c.(1705-1707)ttC>ttT	p.F569F	PPP6R1_ENST00000587283.1_Silent_p.F569F	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	569					regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						CATTGAAGCCGAAGTGGTCAA	0.612000													5	19					0	0	1	0	0
RNASE11	122651	broad.mit.edu	37	14	21052444	21052444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21052444G>A	ENST00000335950.4	-	3	652	c.190C>T	c.(190-192)Ctc>Ttc	p.L64F	RNASE11_ENST00000398009.2_Missense_Mutation_p.L64F|RNASE11_ENST00000398008.2_Missense_Mutation_p.L64F|RNASE11_ENST00000555841.1_Missense_Mutation_p.L64F|RNASE11_ENST00000553849.1_Missense_Mutation_p.L64F|RNASE11_ENST00000432835.2_Missense_Mutation_p.L64F	NM_145250.3	NP_660293.1	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	64						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(6)|lung(7)|ovary(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	21	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		GACATGCTGAGGCTGGTATTT	0.393000													90	258					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29104780	29104780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29104780G>A	ENST00000261590.8	+	8	1152	c.943G>A	c.(943-945)Gga>Aga	p.G315R		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	315	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			ATTTGCATCAGGAAATGAAGG	0.368000													12	79					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511765	61511765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61511765G>A	ENST00000266070.4	-	16	5868	c.5543C>T	c.(5542-5544)cCc>cTc	p.P1848L	DIDO1_ENST00000395343.1_Missense_Mutation_p.P1848L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1848	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CTCCCCATGGGGATCCTTGCG	0.607000													13	117					0	0	1	0	0
EPSTI1	94240	broad.mit.edu	37	13	43463358	43463358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43463358C>T	ENST00000313640.7	-	12	1033	c.969G>A	c.(967-969)tcG>tcA	p.S323S	EPSTI1_ENST00000313624.7_Intron|EPSTI1_ENST00000398762.3_Intron	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	0										endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		TTAGGTGCCTCGAAAAAACTA	0.294000													21	42					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29632657	29632657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:29632657G>A	ENST00000278882.3	+	8	852	c.472G>A	c.(472-474)Gaa>Aaa	p.E158K	FRG1B_ENST00000358464.4_Missense_Mutation_p.E158K																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATAAGTAAAGAAGAGAGTAA	0.308000													39	970					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212537927	212537927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:212537927C>T	ENST00000342788.4	-	14	1988	c.1678G>A	c.(1678-1680)Gag>Aag	p.E560K	ERBB4_ENST00000436443.1_Missense_Mutation_p.E560K|ERBB4_ENST00000402597.1_Missense_Mutation_p.E560K	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	560	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCATCTTCTCACACTGGGGG	0.463000										TSP Lung(8;0.080)			21	52					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138651571	138651571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138651571C>T	ENST00000298480.5	+	11	975	c.901C>T	c.(901-903)Ctc>Ttc	p.L301F	KCNT1_ENST00000263604.3_Missense_Mutation_p.L282F|KCNT1_ENST00000488444.2_Missense_Mutation_p.L282F|KCNT1_ENST00000371757.2_Missense_Mutation_p.L301F|KCNT1_ENST00000486577.2_Missense_Mutation_p.L262F|KCNT1_ENST00000490355.2_Missense_Mutation_p.L282F|KCNT1_ENST00000487664.1_Missense_Mutation_p.L256F|KCNT1_ENST00000491806.2_Missense_Mutation_p.L268F			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	301						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GAACCTGTCCCTCCTGACCTC	0.667000													11	41					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110465872	110465872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110465872C>T	ENST00000329608.6	+	6	1020	c.629C>T	c.(628-630)cCc>cTc	p.P210L	CSF1_ENST00000369801.1_Missense_Mutation_p.P210L|CSF1_ENST00000344188.5_Missense_Mutation_p.P210L|CSF1_ENST00000369802.3_Missense_Mutation_p.P210L|CSF1_ENST00000420111.2_Intron	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	210					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCTCATCAGCCCCTCGCCCCC	0.617000											OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	103					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862740	14862740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14862740C>T	ENST00000285046.5	+	1	2272	c.2162C>T	c.(2161-2163)tCc>tTc	p.S721F	FGD5_ENST00000543601.1_Missense_Mutation_p.S480F	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	721					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TCCCCCTCCTCCCTCATCTTT	0.582000													25	61					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158299230	158299230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158299230C>T	ENST00000368168.3	-	4	923	c.816G>A	c.(814-816)ggG>ggA	p.G272G		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	272	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					CAGCCGCCTCCCCATCTGCCA	0.587000													24	84					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160755484	160755484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160755484C>T	ENST00000263636.4	-	2	208	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	LY75-CD302_ENST00000504764.1_Missense_Mutation_p.E61K|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.E61K|LY75_ENST00000553424.1_Missense_Mutation_p.E61K|LY75_ENST00000554112.1_Missense_Mutation_p.E61K	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TCCTCAGTTTCATCACAGTCG	0.478000													17	117					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408375	29408375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29408375G>A	ENST00000444197.2	+	1	1293	c.583G>A	c.(583-585)Gaa>Aaa	p.E195K	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CTCGCTTAATGAACTGCAGAT	0.562000													71	143					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6661841	6661841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6661841C>T	ENST00000299441.3	-	2	1415	c.1004G>A	c.(1003-1005)cGa>cAa	p.R335Q		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	335	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCACCATCTCGTGCTTGCAC	0.587000													50	80					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206580936	206580936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206580936C>T	ENST00000360409.3	+	3	1062	c.271C>T	c.(271-273)Cgg>Tgg	p.R91W	NRP2_ENST00000355117.4_Missense_Mutation_p.R91W|NRP2_ENST00000357118.4_Missense_Mutation_p.R91W|NRP2_ENST00000540841.1_Missense_Mutation_p.R91W|NRP2_ENST00000540178.1_Missense_Mutation_p.R91W|NRP2_ENST00000417189.1_Missense_Mutation_p.R91W|NRP2_ENST00000357785.5_Missense_Mutation_p.R91W|NRP2_ENST00000272849.3_Missense_Mutation_p.R91W|NRP2_ENST00000412873.2_Missense_Mutation_p.R91W	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	91	CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						TATCGAGATTCGGGATGGGGA	0.542000													49	112					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41664893	41664893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41664893G>A	ENST00000313860.7	+	15	2082	c.2028G>A	c.(2026-2028)gtG>gtA	p.V676V	LIMCH1_ENST00000513024.1_Silent_p.V505V|LIMCH1_ENST00000396595.3_Silent_p.V522V|LIMCH1_ENST00000381753.4_Silent_p.V510V|LIMCH1_ENST00000512946.1_Silent_p.V676V|LIMCH1_ENST00000514096.1_Silent_p.V517V|LIMCH1_ENST00000509277.1_Silent_p.V510V|LIMCH1_ENST00000512820.1_Silent_p.V664V|LIMCH1_ENST00000508501.1_Silent_p.V676V|LIMCH1_ENST00000503057.1_Silent_p.V1061V|LIMCH1_ENST00000512632.1_Silent_p.V676V|LIMCH1_ENST00000511496.1_Silent_p.V517V	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	676					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TGGCCTTTGTGGAATTTCCCT	0.458000													12	98					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443492	5443492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5443492G>A	ENST00000300778.4	+	1	152	c.62G>A	c.(61-63)gGa>gAa	p.G21E	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GACATCCCTGGATTTGAGGCC	0.502000													47	156					0	0	1	0	0
CYP27A1	1593	broad.mit.edu	37	2	219679167	219679167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219679167C>T	ENST00000258415.4	+	7	1676	c.1249C>T	c.(1249-1251)Ctc>Ttc	p.L417F		NM_000784.3	NP_000775.1	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A, polypeptide 1	417					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(3)|urinary_tract(1)	26		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	TGATGGCTTCCTCTTCCCCAA	0.522000													40	94					0	0	1	0	0
FGF1	2246	broad.mit.edu	37	5	141993537	141993537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141993537C>T	ENST00000359370.6	-	2	235	c.156G>A	c.(154-156)agG>agA	p.R52R	AC005592.2_ENST00000443800.1_RNA|FGF1_ENST00000378046.1_Silent_p.R52R|FGF1_ENST00000407758.1_Silent_p.R52R|FGF1_ENST00000494579.1_Intron|FGF1_ENST00000337706.2_Silent_p.R52R|FGF1_ENST00000419524.2_Silent_p.R52R|FGF1_ENST00000360966.5_Silent_p.R52R|AC005592.2_ENST00000414314.1_RNA	NM_000800.4|NM_001144892.2|NM_001144934.1|NM_001144935.1|NM_001257205.1|NM_001257206.1|NM_001257207.1|NM_001257210.1|NM_001257212.1|NM_033137.2	NP_000791.1|NP_001138364.1|NP_001138406.1|NP_001138407.1|NP_001244134.1|NP_001244135.1|NP_001244136.1|NP_001244139.1|NP_001244141.1|NP_149128.1	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic)	52					angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding			large_intestine(1)|lung(2)	3		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	GCTGGTCGCTCCTGTCCCTTG	0.537000													7	57					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219896315	219896315	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219896315G>A	ENST00000341552.5	-	7	794	c.711C>T	c.(709-711)gcC>gcT	p.A237A	CCDC108_ENST00000453220.1_Silent_p.A237A|CCDC108_ENST00000410037.1_Silent_p.A172A|CCDC108_ENST00000409865.3_Silent_p.A226A|CCDC108_ENST00000441968.1_Silent_p.A237A	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	237						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGGCAGGGTGGCCCGTAGGC	0.607000													33	121					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108363052	108363052	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108363052C>T	ENST00000361582.3	+	14	1413	c.1183C>T	c.(1183-1185)Cat>Tat	p.H395Y	DZIP3_ENST00000463306.1_Missense_Mutation_p.H395Y	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	395					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TTATTTCTATCATCTGCTTCA	0.303000													24	67					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999275	27999275	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27999275G>A	ENST00000441525.1	-	1	291	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	59										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						CATCGTTCAGGAAACCACCAT	0.507000													25	26					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56382215	56382215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56382215G>A	ENST00000301295.6	+	7	2799	c.2377G>A	c.(2377-2379)Gag>Aag	p.E793K	NLRP4_ENST00000587891.1_Missense_Mutation_p.E718K|NLRP4_ENST00000346986.5_Missense_Mutation_p.E737K	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	793							ATP binding	p.E793K(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCACCTCAGCGAGCAGTGCTG	0.493000													21	55					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59271314	59271314	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:59271314C>T	ENST00000320743.3	-	15	2690	c.2404G>A	c.(2404-2406)Gat>Aat	p.D802N	LRIG3_ENST00000379141.4_Missense_Mutation_p.D742N	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	802						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			CATCCGTCATCGTCTAACGAT	0.572000			T	ROS1	NSCLC								21	40					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40139745	40139745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40139745G>A	ENST00000325157.6	-	7	2013	c.1763C>T	c.(1762-1764)tCa>tTa	p.S588L		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	588										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					GCTTATTTGTGAACTATTCAG	0.413000													26	67					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	629880	629880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:629880G>A	ENST00000230449.4	-	4	512	c.377C>T	c.(376-378)cCc>cTc	p.P126L	EXOC2_ENST00000448181.3_Intron	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	126					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TAAGGACAAGGGCGGAATTCC	0.408000													26	91					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169623443	169623443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:169623443C>T	ENST00000366787.3	-	19	3150	c.2901G>A	c.(2899-2901)ttG>ttA	p.L967L	XXyac-YX65C7_A.2_ENST00000444188.1_RNA|THBS2_ENST00000488355.1_5'UTR	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	967	TSP C-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CTTTGGGATCCAAGGGGACCA	0.498000													20	41					0	0	1	0	0
TMEM8A	58986	broad.mit.edu	37	16	426755	426755	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:426755G>A	ENST00000431232.2	-	5	853	c.693C>T	c.(691-693)tcC>tcT	p.S231S	TMEM8A_ENST00000250930.3_Silent_p.S38S	NM_021259.2	NP_067082.2	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A	231					cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						GGCTCCCATTGGACACGCAGT	0.667000													4	27					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61742998	61742998	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:61742998C>T	ENST00000423902.2	+	15	4119	c.3640C>T	c.(3640-3642)Cag>Tag	p.Q1214*	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1214			Q -> R (in CHARGES).		central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AACAAACATTCAGAAGAAATA	0.378000													39	109					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179497087	179497087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179497087C>T	ENST00000589042.1	-	236	43758	c.43534G>A	c.(43534-43536)Gaa>Aaa	p.E14512K	TTN_ENST00000342992.6_Missense_Mutation_p.E11944K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E12871K|TTN_ENST00000342175.6_Missense_Mutation_p.E5639K|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E5572K|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E5447K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12871							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGCACTTTCCTTCTCTTTG	0.403000													9	12					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112020521	112020521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112020521G>A	ENST00000374566.3	-	7	1205	c.688C>T	c.(688-690)Cgg>Tgg	p.R230W	EPB41L4B_ENST00000374557.4_Missense_Mutation_p.R230W	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	230	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGAATGAACCGAAACTCAGAC	0.443000													12	65					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40433618	40433618	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:40433618G>A	ENST00000301825.3	+	3	263	c.145G>A	c.(145-147)Gag>Aag	p.E49K	ENTPD3-AS1_ENST00000439293.1_RNA|ENTPD3-AS1_ENST00000452768.1_RNA|ENTPD3_ENST00000445129.1_Missense_Mutation_p.E49K|ENTPD3-AS1_ENST00000425156.1_RNA|ENTPD3_ENST00000456402.1_Missense_Mutation_p.E49K	NM_001248.2	NP_001239.2	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase 3	49						integral to membrane	ATP binding|hydrolase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		CCACAAGCAAGAGGTCCTCCC	0.468000													24	84					0	0	1	0	0
OR8K1	390157	broad.mit.edu	37	11	56113718	56113718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56113718C>T	ENST00000279783.2	+	1	298	c.204C>T	c.(202-204)ttC>ttT	p.F68F		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F68F(1)		large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TGTACTTTTTCCTTAGACATT	0.408000										HNSCC(65;0.19)			45	144					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149753822	149753822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149753822C>T	ENST00000451292.1	+	8	1064	c.956C>T	c.(955-957)cCc>cTc	p.P319L	TCOF1_ENST00000504761.2_Missense_Mutation_p.P319L|TCOF1_ENST00000445265.2_Missense_Mutation_p.P242L|TCOF1_ENST00000377797.3_Missense_Mutation_p.P319L|TCOF1_ENST00000394269.3_Missense_Mutation_p.P319L|TCOF1_ENST00000323668.7_Missense_Mutation_p.P242L|TCOF1_ENST00000439160.2_Missense_Mutation_p.P319L|TCOF1_ENST00000513346.1_Missense_Mutation_p.P319L			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	319					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCCCAGCACCCCCTGGGAAG	0.597000													4	13					0	0	1	0	0
OR2AE1	81392	broad.mit.edu	37	7	99473921	99473921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99473921C>T	ENST00000316368.2	-	1	759	c.736G>A	c.(736-738)Gtg>Atg	p.V246M		NM_001005276.1	NP_001005276.1	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE, member 1	246					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)	11	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGAGAAACCACCGTGAGGTGG	0.478000													38	85					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183713541	183713541	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183713541C>T	ENST00000511685.1	+	26	5839	c.5716C>T	c.(5716-5718)Cga>Tga	p.R1906*	TENM3_ENST00000406950.2_Nonsense_Mutation_p.R1906*					teneurin transmembrane protein 3																		GCAGACCATCCGATCCATTGG	0.542000													22	53					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133787240	133787240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133787240G>A	ENST00000372338.4	-	5	1127	c.885C>T	c.(883-885)ttC>ttT	p.F295F	FIBCD1_ENST00000253018.4_Silent_p.F137F|FIBCD1_ENST00000448616.1_Silent_p.F295F|FIBCD1_ENST00000372337.2_Silent_p.F137F	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	295	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		AGCCCCGGAAGAAGTTCACGG	0.677000													5	8					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101679563	101679563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101679563C>T	ENST00000261637.4	+	4	404	c.230C>T	c.(229-231)tCa>tTa	p.S77L		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	77					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						AAATGCCAATCATTCAATCAG	0.358000													36	85					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39696876	39696876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:39696876G>A	ENST00000395670.3	-	35	5044	c.4625C>T	c.(4624-4626)cCt>cTt	p.P1542L	KIF21A_ENST00000361961.3_Missense_Mutation_p.P1528L|KIF21A_ENST00000544797.2_Missense_Mutation_p.P1504L|KIF21A_ENST00000541463.2_Missense_Mutation_p.P1488L|KIF21A_ENST00000361418.5_Missense_Mutation_p.P1541L			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1541					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				ATCATAATGAGGGGGTTCAAA	0.388000													10	119					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167162335	167162335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167162335C>T	ENST00000375387.4	-	5	906	c.566G>A	c.(565-567)tGg>tAg	p.W189*	SCN9A_ENST00000409435.1_Nonsense_Mutation_p.W188*|SCN9A_ENST00000409672.1_Nonsense_Mutation_p.W188*|SCN9A_ENST00000303354.6_Nonsense_Mutation_p.W189*			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	188						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CAGCCAGTTCCACGGGTCACG	0.373000													20	62					0	0	1	0	0
ZNF8	7554	broad.mit.edu	37	19	58805887	58805887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58805887C>T	ENST00000196548.5	+	4	844	c.713C>T	c.(712-714)tCc>tTc	p.S238F	AC010642.1_ENST00000591325.1_3'UTR	NM_021089.2	NP_066575.2	P17098	ZNF8_HUMAN	zinc finger protein 8	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	19		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		CACAGAGATTCCAGTCAGGCC	0.478000													15	59					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54867965	54867965	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54867965C>T	ENST00000391743.3	-	6	852	c.572_splice	c.e6+1	p.R191_splice	LAIR1_ENST00000391742.2_Splice_Site_p.R209_splice|LAIR1_ENST00000474878.1_Splice_Site_p.R191_splice|LAIR1_ENST00000434277.2_Splice_Site_p.R208_splice|LAIR1_ENST00000313038.6_Splice_Site_p.R202_splice|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000348231.4_Splice_Site_p.R192_splice			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	209						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		GGGGCCTCACCTCTGCTGTGG	0.592000													13	107					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113105810	113105810	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113105810C>G	ENST00000316851.7	+	13	1719	c.1719C>G	c.(1717-1719)gcC>gcG	p.A573A	NCAM1_ENST00000533760.1_Silent_p.A455A|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Silent_p.A582A	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	583	Fibronectin type-III 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		CAACGTACGCCGTAAGGCTGG	0.552000													6	11					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616180	248616180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248616180C>T	ENST00000342927.3	+	1	104	c.82C>T	c.(82-84)Ctc>Ttc	p.L28F		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCCCGGGCTTCTCTTTGCAAT	0.527000													36	275					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9100181	9100181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9100181G>A	ENST00000377424.4	-	6	818	c.639C>T	c.(637-639)ttC>ttT	p.F213F	SLC2A5_ENST00000377414.3_3'UTR|SLC2A5_ENST00000536305.1_Silent_p.F154F|SLC2A5_ENST00000535586.1_Silent_p.F98F	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	213					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGCTCTCGGGGAAGAAGGGCA	0.682000													3	8					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46267784	46267784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:46267784C>T	ENST00000372004.3	+	14	2761	c.2545C>T	c.(2545-2547)Cgt>Tgt	p.R849C	NCOA3_ENST00000371997.3_Missense_Mutation_p.R859C|NCOA3_ENST00000371998.3_Missense_Mutation_p.R849C|NCOA3_ENST00000341724.6_Intron	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	849					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GCAGTCTATTCGTCCTCCATA	0.373000													53	103					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73056942	73056942	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:73056942T>C	ENST00000261180.4	+	19	3138	c.3042T>C	c.(3040-3042)ctT>ctC	p.L1014L		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1014					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						AAGACGAGCTTTTCCAATGGT	0.393000													16	31					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57437680	57437680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57437680C>T	ENST00000442789.2	-	11	1139	c.852G>A	c.(850-852)caG>caA	p.Q284Q	MYO1A_ENST00000544473.1_Silent_p.Q122Q|MYO1A_ENST00000300119.3_Silent_p.Q284Q	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	284	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TCCCACTGGCCTGGAACTCAT	0.552000													15	36					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110765834	110765834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110765834C>T	ENST00000369787.3	+	2	954	c.927C>T	c.(925-927)ttC>ttT	p.F309F	KCNC4_ENST00000412512.2_Intron|KCNC4_ENST00000438661.2_Silent_p.F309F|KCNC4_ENST00000413138.3_Silent_p.F309F	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	309					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGCTGGACTTCGTCAAGAACC	0.607000													23	76					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68919784	68919784	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68919784C>T	ENST00000356291.2	-	10	1219	c.1158_splice	c.e10-1	p.G387_splice	RP11-453E17.1_ENST00000500538.2_RNA	NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	387	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						ACCAGAATCTCCCTGAAATAA	0.358000													20	77					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133044138	133044138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133044138C>T	ENST00000262283.5	-	16	1756	c.1657G>A	c.(1657-1659)Gac>Aac	p.D553N	OC90_ENST00000443356.2_Missense_Mutation_p.D357N|OC90_ENST00000254627.3_Missense_Mutation_p.D341N|OC90_ENST00000603859.1_Missense_Mutation_p.D341N			Q02509	OC90_HUMAN	otoconin 90	357					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CTGTCTAGGTCATCCCTTGGC	0.557000													9	19					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100594382	100594382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100594382C>T	ENST00000471714.1	-	8	917	c.808G>A	c.(808-810)Gaa>Aaa	p.E270K	ABI3BP_ENST00000495063.1_Missense_Mutation_p.E270K|ABI3BP_ENST00000284322.5_Missense_Mutation_p.E270K			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	270						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GGAGCTTTTTCTGGGGATTTA	0.438000													19	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071513	9071513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9071513G>A	ENST00000397910.4	-	3	16136	c.15933C>T	c.(15931-15933)acC>acT	p.T5311T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5313	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCATGAGAGTGGTCACCTCTG	0.532000													14	71					0	0	1	0	0
EPO	2056	broad.mit.edu	37	7	100320391	100320391	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100320391C>A	ENST00000252723.2	+	4	532	c.351C>A	c.(349-351)ccC>ccA	p.P117P		NM_000799.2	NP_000790.2	P01588	EPO_HUMAN	erythropoietin	117					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)|endometrium(2)|lung(7)|prostate(1)	12	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CGTGGGAGCCCCTGCAGCTGC	0.652000													19	39					5.26018e-13	5.28572e-13	1	1	0
MTAP	4507	broad.mit.edu	37	9	21859377	21859377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21859377C>T	ENST00000380172.4	+	7	972	c.766C>T	c.(766-768)Cct>Tct	p.P256S	RP11-145E5.5_ENST00000404796.2_Intron|MTAP_ENST00000580900.1_Missense_Mutation_p.P256S|RP11-70L8.4_ENST00000581788.1_RNA|MTAP_ENST00000460874.2_Missense_Mutation_p.P273S	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	256					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	CACTACCATACCTCAGATAGG	0.458000													5	47					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32341039	32341039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32341039C>T	ENST00000375200.1	+	5	916	c.551C>T	c.(550-552)cCt>cTt	p.P184L	ZNF341_ENST00000342427.2_Missense_Mutation_p.P184L			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	184	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						cctcctccacctcctccacca	0.612000													31	57					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25664416	25664416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25664416G>A	ENST00000382051.3	+	3	252	c.202G>A	c.(202-204)Gac>Aac	p.D68N	SLC34A2_ENST00000503434.1_Missense_Mutation_p.D67N|SLC34A2_ENST00000504570.1_Missense_Mutation_p.D67N	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	68					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TGAGGTGGATGACCCCTGGAA	0.522000			T	ROS1	NSCLC								31	79					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64084892	64084892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64084892G>A	ENST00000295902.6	-	8	2955	c.2370C>T	c.(2368-2370)ttC>ttT	p.F790F	PRICKLE2_ENST00000564377.1_Silent_p.F846F|RP11-129B22.1_ENST00000482609.1_RNA	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	790						cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GTTCTCCTAGGAAATAGCCCT	0.567000													22	64					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94749806	94749806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94749806G>A	ENST00000283357.5	+	4	495	c.449G>A	c.(448-450)cGa>cAa	p.R150Q		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	150			R -> G (in dbSNP:rs10042271).							central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		CATGGCTTTCGAAAAGAGGAA	0.493000													41	81					0	0	1	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998909	8998909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8998909G>A	ENST00000310455.3	-	2	403	c.253C>T	c.(253-255)Ccg>Tcg	p.P85S	PPP1R3B_ENST00000519699.1_Missense_Mutation_p.P85S	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	85					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		ATATCTAGCGGGTCATCGAAT	0.532000													10	124					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38877410	38877410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38877410C>T	ENST00000359357.3	+	63	9233	c.8979C>T	c.(8977-8979)ttC>ttT	p.F2993F	DNAH8_ENST00000441566.1_Silent_p.F2957F|DNAH8_ENST00000449981.2_Silent_p.F3210F					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CCTCCTACTTCCTTTCAGACT	0.448000													28	81					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183226214	183226214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183226214G>A	ENST00000341319.3	-	3	577	c.542C>T	c.(541-543)gCt>gTt	p.A181V		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	181	BACK.									breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTGTGTGTCAGCCAGCCTCAG	0.488000													31	85					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102269264	102269264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102269264G>A	ENST00000370345.3	-	4	305	c.208C>T	c.(208-210)Cac>Tac	p.H70Y	NDUFB8_ENST00000531258.1_Intron|SEC31B_ENST00000370329.5_Missense_Mutation_p.H70Y|SEC31B_ENST00000535773.1_Intron|SEC31B_ENST00000451524.1_Missense_Mutation_p.H70Y|NDUFB8_ENST00000557395.1_Intron	NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	70					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		ACCAGCTTGTGAAACCTATAA	0.502000											OREG0020441	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	15					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55873040	55873040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55873040G>A	ENST00000388975.3	-	9	1146	c.1030C>T	c.(1030-1032)Caa>Taa	p.Q344*		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	344					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTCTGACATTGATCATAGAAC	0.348000													12	28					0	0	1	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45695524	45695524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45695524C>T	ENST00000305560.6	+	1	996	c.897C>T	c.(895-897)ctC>ctT	p.L299L	SPATA5L1_ENST00000559860.1_Silent_p.L299L	NM_024063.2	NP_076968.2	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	299						cytoplasm	ATP binding|nucleoside-triphosphatase activity			kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GACCCAGCCTCCTCTTCCTGG	0.726000													5	13					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11008269	11008269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11008269C>T	ENST00000377004.4	-	12	1922	c.1923G>A	c.(1921-1923)atG>atA	p.M641I	C1orf127_ENST00000377008.4_Missense_Mutation_p.M474I	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	492										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		ATGAAAGGTCCATGTGCCCCC	0.647000													8	92					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18258341	18258341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18258341G>A	ENST00000286479.3	+	2	935	c.828G>A	c.(826-828)ggG>ggA	p.G276G	NAT2_ENST00000520116.1_Silent_p.G146G	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	276					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		TTTCCTTGGGGAGAAATCTCG	0.358000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				17	62					0	0	1	0	0
BCHE	590	broad.mit.edu	37	3	165503968	165503968	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:165503968C>T	ENST00000264381.3	-	3	1815	c.1649G>A	c.(1648-1650)tGg>tAg	p.W550*	BCHE_ENST00000540653.1_Nonsense_Mutation_p.W12*	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	550					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAATGATGTCCAGAATCGACA	0.353000													10	66					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207751211	207751211	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207751211G>A	ENST00000367049.4	+	29	4599	c.4599G>A	c.(4597-4599)gaG>gaA	p.E1533E	CR1_ENST00000400960.2_Silent_p.E1083E|CR1_ENST00000367052.1_Silent_p.E1083E|CR1_ENST00000367053.1_Silent_p.E1083E|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367051.1_Silent_p.E1083E|RP11-78B10.2_ENST00000597497.1_RNA	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1083	Sushi 24.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCAACAGAGAGAATTTTCACT	0.473000													21	102					0	0	1	0	0
DEGS2	123099	broad.mit.edu	37	14	100615443	100615443	+	Silent	SNP	G	G	A	rs145891510		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100615443G>A	ENST00000305631.5	-	2	1262	c.687C>T	c.(685-687)ttC>ttT	p.F229F	DEGS2_ENST00000553834.1_Intron|DEGS2_ENST00000557117.1_5'UTR	NM_206918.2	NP_996801.2	Q6QHC5	DEGS2_HUMAN	delta(4)-desaturase, sphingolipid 2	229					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity	p.F229F(2)		breast(1)|lung(6)|skin(1)	8		Melanoma(154;0.212)				GCTCGGCCACGAAGTGGCCCG	0.622000													37	90					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48698262	48698262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48698262G>A	ENST00000544264.1	-	1	2086	c.1806C>T	c.(1804-1806)atC>atT	p.I602I	CELSR3_ENST00000164024.4_Silent_p.I602I			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	602	Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCACCACCTGGATCTCGCCAG	0.607000													8	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179614317	179614317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179614317G>A	ENST00000360870.5	-	46	13032	c.12810C>T	c.(12808-12810)tcC>tcT	p.S4270S	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	416							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGATCTCTGGAATATTTTC	0.383000													32	62					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147120535	147120535	+	Missense_Mutation	SNP	C	C	T	rs148365070	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:147120535C>T	ENST00000383075.3	-	2	562	c.50G>A	c.(49-51)cGa>cAa	p.R17Q	ZIC4_ENST00000525172.2_Missense_Mutation_p.R67Q|ZIC4_ENST00000425731.3_Missense_Mutation_p.R55Q|ZIC4_ENST00000491672.1_Missense_Mutation_p.R17Q|ZIC4_ENST00000473123.1_Missense_Mutation_p.R17Q|ZIC4_ENST00000484399.1_Missense_Mutation_p.R17Q	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	17						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						AAGAGTGTTTCGGTAAAGCCG	0.353000													43	147					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54849490	54849490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54849490G>A	ENST00000291759.4	-	4	428	c.372C>T	c.(370-372)acC>acT	p.T124T		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	124	Ig-like C2-type 2.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GTGCGGACAGGGTGGGTCTGC	0.572000													13	46					0	0	1	0	0
TBC1D21	161514	broad.mit.edu	37	15	74177154	74177154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74177154C>T	ENST00000300504.2	+	5	483	c.400C>T	c.(400-402)Ccc>Tcc	p.P134S	TBC1D21_ENST00000562056.1_Intron|TBC1D21_ENST00000535547.2_Missense_Mutation_p.P98S	NM_153356.1	NP_699187.1	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	134	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	17						TGACAAAGATCCCCTGGGCAA	0.522000													16	40					0	0	1	0	0
INPP5B	3633	broad.mit.edu	37	1	38355359	38355359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38355359G>A	ENST00000373023.2	-	9	1000	c.907C>T	c.(907-909)Cgc>Tgc	p.R303C	INPP5B_ENST00000373026.1_Missense_Mutation_p.R303C|INPP5B_ENST00000373027.1_Missense_Mutation_p.R59C|INPP5B_ENST00000373024.3_Missense_Mutation_p.R223C	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	303					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GTGGAGGAGCGAACCATGTCA	0.388000													44	140					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101060585	101060585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:101060585G>A	ENST00000394095.2	-	15	2198	c.2145C>T	c.(2143-2145)ttC>ttT	p.F715F	SENP7_ENST00000314261.7_Silent_p.F649F|SENP7_ENST00000358203.3_Silent_p.F551F|SENP7_ENST00000394091.1_Silent_p.F551F|SENP7_ENST00000348610.3_Silent_p.F682F|SENP7_ENST00000394094.2_Silent_p.F650F	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	715					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GCTTCTGCAGGAAGGTGTAAG	0.438000													18	48					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36642158	36642158	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36642158G>A	ENST00000373448.2	-	3	299	c.61C>T	c.(61-63)Ctc>Ttc	p.L21F	TTI1_ENST00000373447.3_Missense_Mutation_p.L21F|TTI1_ENST00000449821.1_Missense_Mutation_p.L21F|TTI1_ENST00000487362.1_5'UTR	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	21							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						GTCTTTGTGAGCTGAACACAG	0.507000													24	161					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72945959	72945959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:72945959C>T	ENST00000262209.4	-	23	2995	c.2788G>A	c.(2788-2790)Gaa>Aaa	p.E930K	RP11-383H13.1_ENST00000457356.4_Intron|RP11-383H13.1_ENST00000524152.1_Intron|RP11-383H13.1_ENST00000537896.1_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	930						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TGTGCCAATTCATTTCTCAGA	0.378000													10	70					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33840370	33840370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33840370C>T	ENST00000389232.4	+	9	850	c.780C>T	c.(778-780)gcC>gcT	p.A260A	RYR3_ENST00000415757.3_Silent_p.A260A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	260	MIR 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGACTCGAGCCAGGTCTCTTT	0.512000													4	24					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	625222	625222	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:625222G>A	ENST00000588649.2	-	4	939	c.855C>T	c.(853-855)ttC>ttT	p.F285F		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	285					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTCACCATGAATAACACAT	0.622000													27	77					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122795646	122795646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:122795646G>A	ENST00000227349.2	+	4	1203	c.906G>A	c.(904-906)caG>caA	p.Q302Q	C11orf63_ENST00000531316.1_Silent_p.Q302Q	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	302										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		CGTCTATTCAGAATGCCAAGG	0.408000													18	92					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43325417	43325417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43325417G>A	ENST00000361428.2	-	3	712	c.635C>T	c.(634-636)cCt>cTt	p.P212L	ZNF318_ENST00000318149.3_Missense_Mutation_p.P212L	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	212					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GGGACTGAGAGGCCCTTCCTC	0.478000													35	101					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606170	21606170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:21606170G>A	ENST00000281523.2	-	3	690	c.172C>T	c.(172-174)Ccg>Tcg	p.P58S	ZNF385D-AS1_ENST00000412369.1_RNA|ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	58						nucleus	nucleic acid binding|zinc ion binding	p.P58T(1)		NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						TTCTGAATCGGGTCCATCTGT	0.358000													18	69					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713683	46713683	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46713683G>T	ENST00000318962.4	-	23	2564	c.2481C>A	c.(2479-2481)tcC>tcA	p.S827S	ALS2CL_ENST00000415953.1_Silent_p.S827S|ALS2CL_ENST00000383742.3_Silent_p.S174S	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	827	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CCCTGACCAGGGAGTACCTCT	0.647000													9	34					0.00829132	0.00829501	1	1	0
ZNF597	146434	broad.mit.edu	37	16	3487274	3487274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3487274G>A	ENST00000301744.4	-	4	660	c.425C>T	c.(424-426)tCt>tTt	p.S142F	LA16c-306E5.2_ENST00000575785.1_RNA	NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						AAGAATTTCAGAAAGTGTGTT	0.408000													32	127					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120690526	120690526	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120690526C>T	ENST00000527524.2	+	6	695	c.408C>T	c.(406-408)acC>acT	p.T136T	GRIK4_ENST00000438375.2_Silent_p.T136T			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	136					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GATTCACAACCCTGAACCTCC	0.557000													104	279					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50909687	50909687	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50909687C>T	ENST00000440232.2	+	12	1460	c.1407C>T	c.(1405-1407)ctC>ctT	p.L469L	POLD1_ENST00000599857.1_Silent_p.L469L|POLD1_ENST00000595904.1_Silent_p.L469L	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	469					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		AGTACAAGCTCCGCTCCTACA	0.657000								DNA polymerases (catalytic subunits)					4	4					0	0	1	0	0
VCPIP1	80124	broad.mit.edu	37	8	67578798	67578798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:67578798G>A	ENST00000310421.4	-	1	654	c.396C>T	c.(394-396)ccC>ccT	p.P132P		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	132					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			GAGCTAATATGGGCGACAACA	0.557000													27	65					0	0	1	0	0
WNT7B	7477	broad.mit.edu	37	22	46327170	46327170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46327170C>T	ENST00000339464.4	-	3	752	c.378G>A	c.(376-378)ggG>ggA	p.G126G	WNT7B_ENST00000410058.1_Silent_p.G126G|WNT7B_ENST00000410089.1_Silent_p.G110G|WNT7B_ENST00000409496.3_Silent_p.G130G	NM_058238.2	NP_478679.1	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family, member 7B	126					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	19		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		TGCTCAGGTTCCCTTGGCTGC	0.687000													25	47					0	0	1	0	0
OR1L3	26735	broad.mit.edu	37	9	125437581	125437581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125437581C>T	ENST00000304820.2	+	1	267	c.173C>T	c.(172-174)cCt>cTt	p.P58L		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						CTTCAAAACCCTATGTATTTT	0.413000													44	184					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144944740	144944740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144944740C>T	ENST00000525985.1	-	2	2753	c.2682G>A	c.(2680-2682)gaG>gaA	p.E894E				P58107	EPIPL_HUMAN	epiplakin 1	894						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGATACCGGCCTCCAGGAGCT	0.662000													5	16					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176003124	176003124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176003124G>A	ENST00000510636.1	+	12	1406	c.1132G>A	c.(1132-1134)Gag>Aag	p.E378K	CDHR2_ENST00000261944.5_Missense_Mutation_p.E378K|CDHR2_ENST00000506348.1_Missense_Mutation_p.E378K	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	378	Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CTACGTGGACGAGCATGCCTC	0.627000													18	66					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71707098	71707098	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71707098G>C	ENST00000356340.3	+	36	2561	c.2025_splice	c.e36+1	p.R675_splice	COL13A1_ENST00000517713.1_Splice_Site_p.R626_splice|COL13A1_ENST00000398973.3_Splice_Site_p.R649_splice|COL13A1_ENST00000398972.3_Splice_Site_p.R661_splice|COL13A1_ENST00000357811.3_Splice_Site_p.R641_splice|COL13A1_ENST00000398966.3_Splice_Site_p.R653_splice|COL13A1_ENST00000522165.1_Splice_Site_p.R644_splice|COL13A1_ENST00000398971.3_Splice_Site_p.R660_splice|COL13A1_ENST00000520133.1_Splice_Site_p.R597_splice|COL13A1_ENST00000520267.1_Splice_Site_p.R603_splice|COL13A1_ENST00000398968.3_Splice_Site_p.R656_splice|COL13A1_ENST00000398978.3_Splice_Site_p.R675_splice|COL13A1_ENST00000398974.3_Splice_Site_p.R663_splice|COL13A1_ENST00000398964.3_Splice_Site_p.R646_splice|COL13A1_ENST00000354547.3_Splice_Site_p.R653_splice|COL13A1_ENST00000398969.3_Splice_Site_p.R603_splice			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	675	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AGGGAAACCGGGTGAGTCTGA	0.507000													10	44					0	0	1	0	0
FTH1P10	2502	broad.mit.edu	37	5	17353944	17353944	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:17353944G>A	ENST00000401830.3	-	0	789					NR_002201.1																						GGTGACCAGGGAAGTCACCCC	0.458000													10	22					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55144597	55144597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55144597G>A	ENST00000257290.5	+	15	2402	c.2071G>A	c.(2071-2073)Gat>Aat	p.D691N	FIP1L1_ENST00000507166.1_Missense_Mutation_p.D451N	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	691	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TAAGAATAGGGATAGCTTCCT	0.463000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			19	79					0	0	1	0	0
WARS	7453	broad.mit.edu	37	14	100813129	100813129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100813129G>A	ENST00000355338.2	-	7	1398	c.780C>T	c.(778-780)ttC>ttT	p.F260F	WARS_ENST00000358655.4_Silent_p.F219F|WARS_ENST00000556645.1_Silent_p.F219F|RP11-638I2.8_ENST00000557226.1_RNA|WARS_ENST00000557135.1_Silent_p.F260F|WARS_ENST00000344102.5_Silent_p.F219F|WARS_ENST00000392882.2_Silent_p.F260F	NM_173701.1	NP_776049.1	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase	260					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	TCACTTGGTTGAAGGTAACAT	0.488000													14	72					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169780186	169780186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169780186C>T	ENST00000263817.6	-	28	4036	c.3912G>A	c.(3910-3912)atG>atA	p.M1304I		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1304	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTTTTTGGGCCATCAGTTCTT	0.512000													15	39					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702757	27702757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27702757G>A	ENST00000438700.3	-	1	540	c.423C>T	c.(421-423)ttC>ttT	p.F141F		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	141					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GCGCCAGCAGGAAGATCCAGG	0.662000													30	78					0	0	1	0	0
LMF2	91289	broad.mit.edu	37	22	50944496	50944496	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50944496G>A	ENST00000216080.5	-	5	835	c.667C>T	c.(667-669)Cga>Tga	p.R223*	LMF2_ENST00000474879.2_Nonsense_Mutation_p.R248*|LMF2_ENST00000505981.1_5'UTR|LMF2_ENST00000380796.3_Nonsense_Mutation_p.R248*			Q9BU23	LMF2_HUMAN	lipase maturation factor 2	248						endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGCAGGCGTCGAATGGGGGCG	0.647000													5	3					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73544831	73544831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73544831G>A	ENST00000224721.6	+	42	5706	c.5701G>A	c.(5701-5703)Gag>Aag	p.E1901K		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1896	Cadherin 18.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GGGCAACCGCGAGCGGGCCTT	0.592000													8	53					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50283911	50283911	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50283911C>A	ENST00000320634.3	-	8	646	c.552G>T	c.(550-552)ggG>ggT	p.G184G	FAIM2_ENST00000550890.1_Silent_p.G138G	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	184					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						TGGACAGCATCCCAGTGAGGT	0.607000													8	62					3.09899e-07	3.10697e-07	1	1	0
DOCK9	23348	broad.mit.edu	37	13	99446979	99446979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:99446979C>T	ENST00000339416.2	-	54	6237	c.6183G>A	c.(6181-6183)acG>acA	p.T2061T	DOCK9_ENST00000376460.1_3'UTR			Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	0					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTAAGACGCTCGTCTTCTCCT	0.512000													12	35					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43412005	43412005	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43412005C>T	ENST00000187910.2	-	4	773	c.706_splice	c.e4-1	p.P236_splice	PSG6_ENST00000292125.2_Splice_Site_p.P236_splice|PSG6_ENST00000402603.4_Intron	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				TGGGCAGCTTCGCTGTGTGGA	0.493000													77	182					0	0	1	0	0
ISM1	140862	broad.mit.edu	37	20	13279769	13279769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:13279769G>A	ENST00000262487.3	+	6	1064	c.1058G>A	c.(1057-1059)gGg>gAg	p.G353E	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	353	AMOP.					extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						GACGCCAGCGGGCCCAAGGAG	0.652000													4	27					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75978949	75978949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75978949G>A	ENST00000274364.6	+	29	3967	c.3670G>A	c.(3670-3672)Gaa>Aaa	p.E1224K	IQGAP2_ENST00000396234.3_Missense_Mutation_p.E720K|IQGAP2_ENST00000502745.1_Missense_Mutation_p.E720K|IQGAP2_ENST00000379730.3_Missense_Mutation_p.E726K	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1224					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GCTCCTGTTGGAACACCAGGA	0.398000													27	70					0	0	1	0	0
HAS2	3037	broad.mit.edu	37	8	122641360	122641360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:122641360G>A	ENST00000303924.4	-	2	758	c.221C>T	c.(220-222)tCc>tTc	p.S74F		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	74						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GGTTTCTAGGGATTTTTTCAT	0.398000													79	246					0	0	1	0	0
LANCL2	55915	broad.mit.edu	37	7	55467736	55467736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55467736C>T	ENST00000254770.2	+	4	1195	c.617C>T	c.(616-618)gCc>gTc	p.A206V	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	206					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TATCTGTATGCCTTACTGTAC	0.473000													33	114					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291034	33291034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:33291034C>T	ENST00000280979.4	+	13	4185	c.4015C>T	c.(4015-4017)Ctt>Ttt	p.L1339F	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1339					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TTTGCCAGATCTTCTAGGTGG	0.433000													13	41					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783815	54783815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54783815C>T	ENST00000391748.1	-	4	313	c.186G>A	c.(184-186)agG>agA	p.R62R	LILRB2_ENST00000391746.1_Silent_p.R62R|LILRB2_ENST00000314446.5_Silent_p.R62R|LILRB2_ENST00000471216.1_5'UTR|LILRB2_ENST00000434421.1_5'UTR|LILRB2_ENST00000391749.4_Silent_p.R62R	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	62	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ATTTTTTCTCCCTATATAGAC	0.552000													30	183					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123821032	123821032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123821032G>A	ENST00000420886.2	-	5	657	c.658C>T	c.(658-660)Cct>Tct	p.P220S	SBNO1_ENST00000602750.1_Missense_Mutation_p.P219S|SBNO1_ENST00000267176.4_Missense_Mutation_p.P219S|SBNO1_ENST00000602398.1_Missense_Mutation_p.P220S	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	220							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		tttACAACAGGAACCTTCTGC	0.418000													11	29					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234862561	234862561	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234862561C>T	ENST00000324695.4	+	10	1181	c.1140_splice	c.e10-1	p.L381_splice	AC005538.5_ENST00000455991.1_RNA|TRPM8_ENST00000433712.2_Splice_Site_p.L69_splice	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	381						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	ATTTCGCCAGCTCAAAGAAAT	0.373000													12	29					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54656240	54656240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54656240C>T	ENST00000406403.1	+	14	3384	c.1781C>T	c.(1780-1782)cCg>cTg	p.P594L	CNOT3_ENST00000221232.5_Missense_Mutation_p.P594L|CNOT3_ENST00000496327.1_3'UTR|CNOT3_ENST00000358389.3_Missense_Mutation_p.P413L			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	594	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GTGAACATACCGCTGTCGCTG	0.652000													16	94					0	0	1	0	0
CRH	1392	broad.mit.edu	37	8	67089149	67089149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:67089149C>T	ENST00000276571.3	-	2	1010	c.564G>A	c.(562-564)agG>agA	p.R188R		NM_000756.2	NP_000747.1	P06850	CRF_HUMAN	corticotropin releasing hormone	188					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity			breast(1)|endometrium(1)|lung(2)|urinary_tract(1)	5		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	CCATGAGTTTCCTGTTGCTGT	0.453000											OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	48					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114196635	114196635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114196635C>T	ENST00000369615.1	+	15	2686	c.2624C>T	c.(2623-2625)cCa>cTa	p.P875L	MAGI3_ENST00000369611.4_Missense_Mutation_p.P875L|MAGI3_ENST00000307546.9_Missense_Mutation_p.P875L|MAGI3_ENST00000369617.4_Missense_Mutation_p.P900L	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	900					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAACCACCTCCAGGAGGTAAG	0.448000													59	223					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183211938	183211938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183211938C>T	ENST00000341319.3	-	5	1314	c.1279G>A	c.(1279-1281)Gga>Aga	p.G427R		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	427								p.G427*(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			TCAAAGCCTCCGATCACATAG	0.453000													39	139					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67430791	67430791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67430791G>A	ENST00000349015.3	-	10	1491	c.1053C>T	c.(1051-1053)ccC>ccT	p.P351P	ALDH3B2_ENST00000530069.1_Silent_p.P351P	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	351					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	CCAGGCCGGAGGGGGCGAGCA	0.617000													20	41					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33540299	33540299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33540299G>A	ENST00000404816.2	+	24	4046	c.3693G>A	c.(3691-3693)caG>caA	p.Q1231Q	LTBP1_ENST00000404525.1_Silent_p.Q852Q|LTBP1_ENST00000402934.1_Silent_p.Q852Q|LTBP1_ENST00000272273.5_Silent_p.Q171Q|LTBP1_ENST00000390003.4_Silent_p.Q906Q|LTBP1_ENST00000418533.2_Silent_p.Q905Q|LTBP1_ENST00000407925.1_Silent_p.Q905Q|LTBP1_ENST00000354476.3_Silent_p.Q1232Q			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1231	EGF-like 12; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCTGCCAGCAGGGTTTCTCAA	0.428000													43	62					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21355829	21355829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21355829C>T	ENST00000313654.9	+	10	1588	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F	LAMA3_ENST00000399516.3_Silent_p.F449F	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	449	Domain V.|Laminin EGF-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCCAAATTTCCACGGAGACA	0.493000													27	79					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210857019	210857019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210857019C>T	ENST00000367007.4	-	11	2662	c.2493G>A	c.(2491-2493)tcG>tcA	p.S831S	KCNH1_ENST00000271751.4_Silent_p.S858S	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	858					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GTGTCTCCATCGACTCAGCCT	0.592000													36	109					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43984301	43984301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43984301G>A	ENST00000282406.4	+	26	3949	c.3839G>A	c.(3838-3840)gGg>gAg	p.G1280E		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1280	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ACTCCAGCAGGGCATGTTACC	0.343000													36	89					0	0	1	0	0
OR2V2	285659	broad.mit.edu	37	5	180582494	180582494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180582494C>T	ENST00000328275.1	+	1	552	c.552C>T	c.(550-552)tcC>tcT	p.S184S		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGATGCTATCCTTGTTGAAGC	0.463000													54	231					0	0	1	0	0
C10orf53	282966	broad.mit.edu	37	10	50902647	50902647	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50902647G>A	ENST00000374111.3	+	3	293	c.281G>A	c.(280-282)tGa>tAa	p.*94*	C10orf53_ENST00000374112.3_Intron|C10orf53_ENST00000535836.1_Intron|C10orf53_ENST00000374113.3_3'UTR	NM_001042427.1	NP_001035892.1	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53	0										endometrium(1)|lung(6)	7		all_neural(218;0.107)				AATGCCTACTGATCTCCTCAT	0.512000													18	47					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130736	45130736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45130736G>A	ENST00000457685.2	-	6	2451	c.1128C>T	c.(1126-1128)ttC>ttT	p.F376F	ZNF334_ENST00000593880.1_Silent_p.F437F|ZNF334_ENST00000347606.4_Silent_p.F414F			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				ATTGACAAAAGAAGGTTTTCT	0.423000													18	168					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716446	142716446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142716446C>T	ENST00000381779.4	-	2	2704	c.2479G>A	c.(2479-2481)Gtc>Atc	p.V827I	SLITRK4_ENST00000356928.1_Missense_Mutation_p.V827I|SLITRK4_ENST00000338017.4_Missense_Mutation_p.V827I	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	827						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAAGGACCTGTAGGTAG	0.403000													36	24					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128680491	128680491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128680491G>A	ENST00000344954.6	+	9	1256	c.868G>A	c.(868-870)Gag>Aag	p.E290K	FLI1_ENST00000429175.2_Missense_Mutation_p.E323K|FLI1_ENST00000525560.1_Missense_Mutation_p.E130K|FLI1_ENST00000281428.8_Missense_Mutation_p.E257K|FLI1_ENST00000534087.1_Missense_Mutation_p.E290K			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	323					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GCGCTGGGGCGAGCGGAAAAG	0.552000			T	EWSR1	Ewing sarcoma								12	28					0	0	1	0	0
FOXD4	2298	broad.mit.edu	37	9	116866	116866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116866C>T	ENST00000382500.2	-	1	1551	c.1254G>A	c.(1252-1254)ggG>ggA	p.G418G		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	418					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGGTGAGGTCCCCTCTCCGC	0.697000													7	46					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98819884	98819884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98819884G>A	ENST00000266058.4	-	10	1218	c.973C>T	c.(973-975)Cct>Tct	p.P325S	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371041.3_Missense_Mutation_p.P325S|SLIT1_ENST00000371070.4_Missense_Mutation_p.P325S	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	325					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GCTCCAGGAGGGATGGACTTG	0.622000													30	75					0	0	1	0	0
SND1	27044	broad.mit.edu	37	7	127343298	127343298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127343298C>T	ENST00000354725.3	+	7	955	c.761C>T	c.(760-762)tCg>tTg	p.S254L		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	254	TNase-like 2.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						TTCACTGAGTCGCGACTGCTT	0.493000													37	75					0	0	1	0	0
KRTAP19-8	728299	broad.mit.edu	37	21	32410599	32410599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32410599C>T	ENST00000382822.2	-	1	196	c.164G>A	c.(163-165)gGa>gAa	p.G55E		NM_001099219.1	NP_001092689.1	Q3LI54	KR198_HUMAN	keratin associated protein 19-8	55						intermediate filament				endometrium(2)|upper_aerodigestive_tract(1)	3						TCCATATCCTCCGTAGTATAA	0.478000													48	151					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118764585	118764585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118764585G>A	ENST00000292174.4	+	2	508	c.332G>A	c.(331-333)gGc>gAc	p.G111D	BCL9L_ENST00000334801.3_3'UTR	NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	111					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GTGGCCGAGGGCTCTGTGGGC	0.627000													29	61					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50847230	50847230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:50847230C>T	ENST00000404971.1	-	9	2709	c.1370G>A	c.(1369-1371)gGa>gAa	p.G457E	NRXN1_ENST00000402717.3_Missense_Mutation_p.G409E|NRXN1_ENST00000401669.2_Missense_Mutation_p.G417E|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Missense_Mutation_p.G417E|NRXN1_ENST00000405472.3_Missense_Mutation_p.G409E|NRXN1_ENST00000406859.3_Missense_Mutation_p.G417E	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	417	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGGACTGCCTCCAACATAGAA	0.463000													11	24					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724262	38724262	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:38724262C>T	ENST00000342213.2	-	1	1312	c.966G>A	c.(964-966)agG>agA	p.R322R		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	322						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCTCGTCGACCCTGATTGGCC	0.607000													44	119					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174868913	174868913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:174868913G>A	ENST00000393752.2	-	2	2182	c.1190C>T	c.(1189-1191)tCc>tTc	p.S397F		NM_000794.3	NP_000785.1	P21728	DRD1_HUMAN	dopamine receptor D1	397					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	GTCCTCAGAGGAGCCCACAGC	0.542000													6	74					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125282013	125282013	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125282013C>T	ENST00000340750.1	+	1	594	c.594C>T	c.(592-594)gtC>gtT	p.V198V		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						ATGAGCTGGTCATTTTCACAG	0.473000													30	57					0	0	1	0	0
ASGR2	433	broad.mit.edu	37	17	7012127	7012127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7012127G>A	ENST00000380952.2	-	3	469	c.205C>T	c.(205-207)Ctg>Ttg	p.L69L	ASGR2_ENST00000355035.5_Silent_p.L69L|ASGR2_ENST00000254850.7_Silent_p.L50L|ASGR2_ENST00000446679.2_Silent_p.L50L	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172.1|NP_001188281.1|NP_550434.1	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	69					cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	ACCAGCAGCAGGATGTTGAAG	0.632000													21	19					0	0	1	0	0
SCYL2	55681	broad.mit.edu	37	12	100708387	100708387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100708387C>T	ENST00000360820.2	+	8	1527	c.1090C>T	c.(1090-1092)Ccc>Tcc	p.P364S		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	364					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						ACCAAAACTGCCCAAGGTTTG	0.303000													9	59					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166964517	166964517	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:166964517G>A	ENST00000061240.2	+	12	2117	c.1470G>A	c.(1468-1470)tgG>tgA	p.W490*	TLL1_ENST00000507499.1_Nonsense_Mutation_p.W490*	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	490	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AATGTGTGTGGAAAATAACAG	0.433000													61	152					0	0	1	0	0
KRTAP6-2	337967	broad.mit.edu	37	21	31971122	31971122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31971122G>A	ENST00000334897.3	-	1	97	c.72C>T	c.(70-72)ggC>ggT	p.G24G		NM_181604.1	NP_853635.1	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	24						intermediate filament				endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11						CATAGCCATAGCCTAGGCCTT	0.572000													32	70					0	0	1	0	0
SPRED2	200734	broad.mit.edu	37	2	65541092	65541092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:65541092G>A	ENST00000356388.4	-	6	989	c.800C>T	c.(799-801)cCc>cTc	p.P267L	SPRED2_ENST00000443619.2_Missense_Mutation_p.P264L	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	267					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						GTCCACGTAGGGGTAGTTGTA	0.682000													34	84					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141952311	141952311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141952311C>T	ENST00000552471.1	-	4	876	c.557G>A	c.(556-558)gGa>gAa	p.G186E	PRSS58_ENST00000547058.2_Missense_Mutation_p.G186E			Q8IYP2	PRS58_HUMAN	protease, serine, 58	186	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						CTGCCTCCTTCCTGGCACAAT	0.423000													58	119					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590485	156590485	+	Missense_Mutation	SNP	C	C	T	rs148999608		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156590485C>T	ENST00000302938.4	-	2	886	c.791G>A	c.(790-792)aGg>aAg	p.R264K		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	264	Ala-rich.					nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACCTGCTGTCCTTGCTGCTCC	0.587000													42	89					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145114840	145114840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145114840G>A	ENST00000426825.1	-	2	177	c.96C>T	c.(94-96)gtC>gtT	p.V32V	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	32							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GCAGTTTTAAGACCCGCACGT	0.667000													15	50					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940784	22940784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22940784G>A	ENST00000397104.3	-	5	1653	c.1654C>T	c.(1654-1656)Cat>Tat	p.H552Y	ZNF99_ENST00000596209.1_Missense_Mutation_p.H643Y					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTCCAGTATGAATTATCTCA	0.363000													21	68					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132160463	132160463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:132160463C>T	ENST00000511190.1	-	6	2255	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	USP26_ENST00000370832.1_Missense_Mutation_p.D596N|USP26_ENST00000406273.1_Missense_Mutation_p.D596N	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	596					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					GCCAGGATATCTTTGGATTCC	0.398000													31	24					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114268724	114268724	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:114268724C>T	ENST00000393500.3	+	9	932	c.112C>T	c.(112-114)Ctg>Ttg	p.L38L	FOXP2_ENST00000390668.3_Silent_p.L154L|FOXP2_ENST00000403559.4_Silent_p.L130L|FOXP2_ENST00000393494.2_Silent_p.L130L|FOXP2_ENST00000393498.2_Silent_p.L130L|FOXP2_ENST00000360232.4_Silent_p.L130L|FOXP2_ENST00000408937.3_Silent_p.L155L|FOXP2_ENST00000393489.3_Silent_p.L38L|FOXP2_ENST00000393491.3_Silent_p.L38L|FOXP2_ENST00000378237.3_Silent_p.L130L|FOXP2_ENST00000459666.1_3'UTR|FOXP2_ENST00000350908.4_Silent_p.L130L			O15409	FOXP2_HUMAN	forkhead box P2	130					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						GGCTGTCATGCTGCAGCAGGT	0.488000													53	110					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35507460	35507460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35507460C>T	ENST00000217320.3	+	3	250	c.206C>T	c.(205-207)cCa>cTa	p.P69L	TLDC2_ENST00000602922.1_Missense_Mutation_p.P69L	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		TTTCACTTCCCACCAAGAGTC	0.622000													61	177					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104592419	104592419	+	Missense_Mutation	SNP	C	C	T	rs142037395	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104592419C>T	ENST00000369887.3	-	6	1159	c.988G>A	c.(988-990)Gag>Aag	p.E330K		NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	330			Missing (in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities).		androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	TCAATCTCCTCGTAGAGCTTC	0.532000													33	76					0	0	1	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122958467	122958467	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122958467G>A	ENST00000543897.1	-	12	3342	c.987C>T	c.(985-987)gtC>gtT	p.V329V	ZCCHC8_ENST00000536306.1_Silent_p.V329V|ZCCHC8_ENST00000336229.4_Silent_p.V567V|ZCCHC8_ENST00000538116.1_Silent_p.V178V			Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	567						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TTCCCTCCGGGACAGGGAGGT	0.507000													97	265					0	0	1	0	0
GCM1	8521	broad.mit.edu	37	6	52993438	52993438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52993438C>T	ENST00000259803.7	-	6	1088	c.877G>A	c.(877-879)Gat>Aat	p.D293N		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	293						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					GCTTGTAGATCGCCATGATCA	0.473000													9	73					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7773905	7773905	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:7773905A>T	ENST00000358415.4	+	13	1759	c.1593A>T	c.(1591-1593)ggA>ggT	p.G531G	ITIH2_ENST00000379587.4_Silent_p.G520G	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	531					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TGGTGGCAGGAAAATTTGACC	0.433000													47	92					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5204841	5204841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5204841C>T	ENST00000334314.3	-	2	312	c.236G>A	c.(235-237)aGa>aAa	p.R79K						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						TATTTCCTCTCTCTTGACGGT	0.423000													50	175					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81167172	81167172	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81167172G>A	ENST00000525539.1	-	0	5852				PKD1L2_ENST00000533478.1_RNA|PKD1L2_ENST00000534142.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GCCTACCCAGGATTTCTCTGA	0.527000													7	37					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321402	52321402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:52321402G>A	ENST00000356297.4	-	17	2882	c.2782C>T	c.(2782-2784)Ccc>Tcc	p.P928S	PXDNL_ENST00000543296.1_Missense_Mutation_p.P928S	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	928					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.P127S(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTTCCGGAGGGAGGCCAAGGA	0.647000													9	15					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76257129	76257129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76257129C>T	ENST00000529032.1	+	19	3562	c.3562C>T	c.(3562-3564)Ccc>Tcc	p.P1188S	C11orf30_ENST00000525038.1_Missense_Mutation_p.P1189S|C11orf30_ENST00000533248.1_Missense_Mutation_p.P1097S|C11orf30_ENST00000525919.1_Missense_Mutation_p.P1189S|C11orf30_ENST00000524490.1_Missense_Mutation_p.P1090S|C11orf30_ENST00000334736.3_Missense_Mutation_p.P1188S|C11orf30_ENST00000524767.1_Missense_Mutation_p.P1203S|C11orf30_ENST00000343878.3_Intron			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1188					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						AGGATCATTACCCTCCACCCA	0.502000													26	67					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57480853	57480853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57480853G>A	ENST00000371236.2	-	12	1410	c.1147C>T	c.(1147-1149)Ccc>Tcc	p.P383S	DAB1_ENST00000420954.2_Missense_Mutation_p.P381S|DAB1_ENST00000439789.2_Missense_Mutation_p.P297S|DAB1_ENST00000371234.4_Missense_Mutation_p.P383S|DAB1_ENST00000371231.1_Missense_Mutation_p.P416S|DAB1_ENST00000414851.2_Missense_Mutation_p.P365S|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	416					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GGGGTGAGGGGACCTTGGAAC	0.592000													27	67					0	0	1	0	0
IDO1	3620	broad.mit.edu	37	8	39785360	39785360	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39785360C>T	ENST00000518237.1	+	10	1507	c.868C>T	c.(868-870)Cag>Tag	p.Q290*	RP11-44K6.3_ENST00000517623.1_RNA|IDO1_ENST00000522495.1_Nonsense_Mutation_p.Q290*	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	290					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	ACATGCTGCTCAGTTCCTCCA	0.483000													3	9					0	0	1	0	0
TBPL2	387332	broad.mit.edu	37	14	55903639	55903639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:55903639G>A	ENST00000247219.5	-	2	318	c.248C>T	c.(247-249)tCg>tTg	p.S83L		NM_199047.2	NP_950248.1	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	83					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding	p.S83L(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8						TTCAGGGTTCGAATTAAATGC	0.448000													28	97					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204943415	204943415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204943415G>A	ENST00000367172.4	+	13	1716	c.1388G>A	c.(1387-1389)cGa>cAa	p.R463Q	NFASC_ENST00000513543.1_Missense_Mutation_p.R474Q|NFASC_ENST00000338586.6_Missense_Mutation_p.R463Q|NFASC_ENST00000367169.4_Missense_Mutation_p.R463Q|NFASC_ENST00000360049.4_Missense_Mutation_p.R474Q|NFASC_ENST00000367171.4_Missense_Mutation_p.R463Q|NFASC_ENST00000401399.1_Missense_Mutation_p.R463Q|NFASC_ENST00000539706.1_Missense_Mutation_p.R474Q|NFASC_ENST00000403080.1_Missense_Mutation_p.R463Q|NFASC_ENST00000367170.4_Missense_Mutation_p.R463Q|NFASC_ENST00000339876.6_Missense_Mutation_p.R463Q|NFASC_ENST00000404907.1_Missense_Mutation_p.R474Q|NFASC_ENST00000404076.1_Missense_Mutation_p.R457Q|NFASC_ENST00000338515.6_Missense_Mutation_p.R463Q			O94856	NFASC_HUMAN	neurofascin	463	Ig-like C2-type 5.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.R474Q(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCCACACTGCGATGGTAAGTT	0.572000													7	19					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87487747	87487747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87487747G>A	ENST00000327946.7	-	10	1483	c.1398C>T	c.(1396-1398)ttC>ttT	p.F466F	GRID1_ENST00000536331.1_Silent_p.F37F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	466						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CATCTATGGAGAACCCTTTGT	0.493000										Multiple Myeloma(13;0.14)			30	170					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65788286	65788286	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65788286G>A	ENST00000312106.5	-	6	2060	c.1923C>T	c.(1921-1923)gcC>gcT	p.A641A		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	641					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CCCTACCCTGGGCACGGCTGT	0.637000													11	38					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2778188	2778188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2778188G>A	ENST00000399655.1	+	38	4978	c.4713G>A	c.(4711-4713)agG>agA	p.R1571R	CACNA1C_ENST00000347598.4_Silent_p.R1619R|CACNA1C_ENST00000399591.1_Silent_p.R1560R|CACNA1C_ENST00000344100.3_Silent_p.R1593R|CACNA1C_ENST00000399597.1_Silent_p.R1571R|CACNA1C_ENST00000335762.5_Silent_p.R1596R|CACNA1C_ENST00000399595.1_Silent_p.R1560R|CACNA1C_ENST00000399603.1_Silent_p.R1571R|CACNA1C_ENST00000399617.1_Silent_p.R1571R|CACNA1C_ENST00000399606.1_Silent_p.R1591R|CACNA1C_ENST00000399621.1_Silent_p.R1571R|CACNA1C_ENST00000399601.1_Silent_p.R1571R|CACNA1C_ENST00000399638.1_Silent_p.R1599R|CACNA1C_ENST00000399649.1_Silent_p.R1558R|CACNA1C_ENST00000399644.1_Silent_p.R1571R|CACNA1C_ENST00000399629.1_Silent_p.R1588R|CACNA1C_ENST00000327702.7_Silent_p.R1571R|CACNA1C_ENST00000399634.1_Silent_p.R1571R|CACNA1C_ENST00000399637.1_Silent_p.R1571R|CACNA1C_ENST00000406454.3_Silent_p.R1571R|CACNA1C-AS2_ENST00000545526.1_RNA|CACNA1C_ENST00000402845.3_Silent_p.R1571R|CACNA1C_ENST00000399641.1_Silent_p.R1571R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1619					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CGGCCCTGAGGATCAAAACAG	0.572000													40	80					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437486	120437486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:120437486C>T	ENST00000369400.1	-	1	1632	c.1474G>A	c.(1474-1476)Gaa>Aaa	p.E492K		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	492	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CAACGGCCTTCATACTTGCAA	0.488000													26	44					0	0	1	0	0
ZSCAN23	222696	broad.mit.edu	37	6	28403868	28403868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28403868G>A	ENST00000289788.4	-	2	321	c.176C>T	c.(175-177)tCc>tTc	p.S59F	ZSCAN23_ENST00000486481.1_Intron	NM_001012455.1	NP_001012458.1	Q3MJ62	ZSC23_HUMAN	zinc finger and SCAN domain containing 23	59	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|prostate(1)|stomach(2)	4						GGGCCCAGGGGACTCCTGATA	0.552000													18	39					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507766	155507766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155507766C>T	ENST00000302053.3	-	5	893	c.815G>A	c.(814-816)gGa>gAa	p.G272E	FGA_ENST00000403106.3_Missense_Mutation_p.G272E	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	272					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GGTGGAGCCTCCTCGAGTAAT	0.537000													63	121					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179476841	179476841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179476841C>T	ENST00000589042.1	-	267	50521	c.50297G>A	c.(50296-50298)cGa>cAa	p.R16766Q	TTN_ENST00000342992.6_Missense_Mutation_p.R14198Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R15125Q|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R7893Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R7826Q|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R7701Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15125	Ig-like 101.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R14198P(2)|p.R7701P(1)|p.R7893P(1)|p.R7826P(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCAACATGTCGTTTTGTCAC	0.398000													6	21					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088430	9088430	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9088430G>A	ENST00000397910.4	-	1	3588	c.3385C>T	c.(3385-3387)Ctg>Ttg	p.L1129L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1129	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGGAGTCAGAGCTGAGCTT	0.458000													20	55					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914542	51914542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51914542C>T	ENST00000353836.5	-	10	1841	c.1620G>A	c.(1618-1620)aaG>aaA	p.K540K	SIGLEC10_ENST00000339313.5_Silent_p.K635K|SIGLEC10_ENST00000439889.2_Silent_p.K577K|SIGLEC10_ENST00000442846.3_Silent_p.K392K|SIGLEC10_ENST00000525998.1_Silent_p.K450K|SIGLEC10_ENST00000436984.2_Silent_p.K492K|SIGLEC10_ENST00000356298.5_Silent_p.K635K|SIGLEC10_ENST00000432469.2_Silent_p.K457K|SIGLEC10_ENST00000441969.3_Silent_p.K482K	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	635					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		TTTTCTGGTTCTTCTTTGATT	0.532000													51	133					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102904439	102904439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102904439C>T	ENST00000359520.7	+	10	2701	c.2475C>T	c.(2473-2475)tgC>tgT	p.C825C	TECPR2_ENST00000558678.1_Silent_p.C825C	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	825							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						ATATCTGGTGCCTGGACTACA	0.597000											OREG0022547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	146					0	0	1	0	0
TACSTD2	4070	broad.mit.edu	37	1	59042069	59042069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:59042069C>T	ENST00000371225.2	-	1	1097	c.760G>A	c.(760-762)Gag>Aag	p.E254K		NM_002353.2	NP_002344.2	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	254					cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity					all_cancers(7;6.54e-05)					AGCGTGCGCTCCACCTGCAGG	0.642000													8	21					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3632689	3632689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3632689G>A	ENST00000294008.3	-	15	5799	c.5159C>T	c.(5158-5160)tCc>tTc	p.S1720F	RP11-461A8.1_ENST00000573982.1_lincRNA	NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1720	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.|Poly-Ser.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CTCACAGGAGGAAGAACTGAA	0.592000								Direct reversal of damage					4	25					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150267063	150267063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150267063G>A	ENST00000461940.1	+	2	157	c.74G>A	c.(73-75)aGt>aAt	p.S25N	GIMAP4_ENST00000494750.1_Intron|GIMAP4_ENST00000255945.2_Intron			Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	20							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGCATTCAGTGCTCCCCAG	0.592000													10	56					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187042	140187042	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140187042C>T	ENST00000530339.1	+	1	270	c.270C>T	c.(268-270)atC>atT	p.I90I	PCDHA4_ENST00000512229.2_Silent_p.I90I|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.I90I|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGACCGGGAGG	0.622000													40	96					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42128605	42128605	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42128605G>A	ENST00000401548.3	+	11	1369	c.1329G>A	c.(1327-1329)ctG>ctA	p.L443L	MEI1_ENST00000300398.4_5'UTR|MEI1_ENST00000540833.1_Silent_p.L183L|MEI1_ENST00000400107.1_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	443							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CTGCTTTTCTGAGGTGAGAGA	0.542000													16	46					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84366585	84366585	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:84366585C>T	ENST00000428679.2	-	7	1140		c.e7-1		SNAP91_ENST00000521485.1_Splice_Site|SNAP91_ENST00000439399.2_Splice_Site|SNAP91_ENST00000195649.6_Splice_Site|SNAP91_ENST00000369694.2_Splice_Site|SNAP91_ENST00000521743.1_Splice_Site|SNAP91_ENST00000437520.1_Splice_Site|SNAP91_ENST00000520213.1_Splice_Site|SNAP91_ENST00000520302.1_Splice_Site			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa						clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TTGGATGCACCTAGAAAAACA	0.289000													5	9					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171486848	171486848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171486848C>T	ENST00000367742.3	+	6	887	c.645C>T	c.(643-645)atC>atT	p.I215I	PRRC2C_ENST00000426496.2_Silent_p.I213I|PRRC2C_ENST00000338920.4_Silent_p.I213I|PRRC2C_ENST00000392078.3_Silent_p.I215I|PRRC2C_ENST00000476522.1_3'UTR			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	213							protein C-terminus binding										AAAATGATATCCTCAAAGTGG	0.498000													15	36					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15587019	15587019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15587019G>A	ENST00000292609.4	-	2	591	c.462C>T	c.(460-462)acC>acT	p.T154T	PGLYRP2_ENST00000340880.4_Silent_p.T154T			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	154					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						CATCTGGAAAGGTATCTCCAG	0.587000													17	82					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23814665	23814665	+	Missense_Mutation	SNP	G	G	A	rs149856244		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:23814665G>A	ENST00000264867.2	-	9	1996	c.1877C>T	c.(1876-1878)tCg>tTg	p.S626L	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	626	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding	p.S626L(1)		central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GCTGTAGGGCGATCTTGAACG	0.493000													64	119					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38141867	38141867	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38141867C>T	ENST00000308059.6	+	19	2836	c.2815C>T	c.(2815-2817)Cag>Tag	p.Q939*	DLEC1_ENST00000452631.2_Nonsense_Mutation_p.Q939*|DLEC1_ENST00000346219.3_Nonsense_Mutation_p.Q939*			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	939					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCTGCACTGCCAGCATCTGGA	0.582000													36	85					0	0	1	0	0
CARD10	29775	broad.mit.edu	37	22	37903940	37903940	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37903940G>A	ENST00000403299.1	-	7	1303	c.1087C>T	c.(1087-1089)Ctg>Ttg	p.L363L	CARD10_ENST00000251973.5_Silent_p.L363L|CARD10_ENST00000406271.3_Silent_p.L77L			Q9BWT7	CAR10_HUMAN	caspase recruitment domain family, member 10	363					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					TTGAGCCGCAGGTCTTCCATC	0.627000													23	88					0	0	1	0	0
SH3RF3	344558	broad.mit.edu	37	2	110065788	110065788	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:110065788C>T	ENST00000309415.6	+	8	1991	c.1991C>T	c.(1990-1992)cCg>cTg	p.P664L		NM_001099289.1	NP_001092759.1	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	664							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(5)|ovary(2)	18						TGCCCACGGCCGGCCATCCCC	0.677000													5	17					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59211041	59211041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59211041C>T	ENST00000302030.2	+	1	425	c.400C>T	c.(400-402)Ctc>Ttc	p.L134F		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						CAGCCCCCTTCTCTACCCCAC	0.547000													72	278					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47344548	47344548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47344548G>A	ENST00000398879.1	-	21	3070	c.2704C>T	c.(2704-2706)Ccc>Tcc	p.P902S	TNS3_ENST00000311160.9_Missense_Mutation_p.P902S|TNS3_ENST00000355730.3_Missense_Mutation_p.P662S			Q68CZ2	TENS3_HUMAN	tensin 3	902						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GGTCCGATGGGGCTCTCTGAC	0.597000													14	38					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155150523	155150523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155150523G>A	ENST00000392451.2	+	6	1038	c.955G>A	c.(955-957)Ggg>Agg	p.G319R	TRIM46_ENST00000545012.1_Missense_Mutation_p.G193R|TRIM46_ENST00000543729.1_Missense_Mutation_p.G326R|TRIM46_ENST00000368383.3_Missense_Mutation_p.G319R|TRIM46_ENST00000334634.4_Missense_Mutation_p.G319R|TRIM46_ENST00000368382.1_Missense_Mutation_p.G296R|TRIM46_ENST00000368385.4_Missense_Mutation_p.G319R|TRIM46_ENST00000468878.1_3'UTR			Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	319						intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCTGGTGCGGGGGCTGGGGGC	0.617000													19	39					0	0	1	0	0
DZIP1L	199221	broad.mit.edu	37	3	137816641	137816641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:137816641G>A	ENST00000327532.2	-	3	912	c.550C>T	c.(550-552)Cac>Tac	p.H184Y	DZIP1L_ENST00000469243.1_Missense_Mutation_p.H184Y	NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	184						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						cgctggatgtggccccggaga	0.577000											OREG0015831	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	17					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105261008	105261008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:105261008G>A	ENST00000507740.1	+	19	3234	c.2998G>A	c.(2998-3000)Gtg>Atg	p.V1000M	RIMS2_ENST00000262231.10_Missense_Mutation_p.V1025M|RIMS2_ENST00000339750.2_Missense_Mutation_p.V122M|RIMS2_ENST00000406091.3_Missense_Mutation_p.V1186M|RIMS2_ENST00000436393.2_Missense_Mutation_p.V1204M	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1248					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGCTCAGCTAGTGGGACGCCA	0.428000										HNSCC(12;0.0054)			21	52					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660736	77660736	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77660736A>T	ENST00000296043.6	+	5	2363	c.1410A>T	c.(1408-1410)gtA>gtT	p.V470V		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	470					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TCTACCCGGTACCTTCCCTGG	0.577000													29	76					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164095	26164095	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26164095C>T	ENST00000335473.7	+	4	462	c.212C>T	c.(211-213)tCc>tTc	p.S71F	MYO18B_ENST00000536101.1_Missense_Mutation_p.S71F|MYO18B_ENST00000407587.2_Missense_Mutation_p.S71F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	71	Ser-rich.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCAGAAATTTCCATCAGCCAA	0.498000													42	139					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450081	158450081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158450081G>A	ENST00000368152.1	+	1	414	c.414G>A	c.(412-414)atG>atA	p.M138I	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M138I(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					TGGGTGTGATGGGTTATGATC	0.483000													92	272					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111164364	111164364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111164364C>T	ENST00000360467.5	+	48	5271	c.4965C>T	c.(4963-4965)ttC>ttT	p.F1655F		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1655	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCACACCATTCATCGAATGCA	0.632000													29	85					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158735998	158735998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158735998C>T	ENST00000335094.2	-	1	494	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					AAGGAAATTTCAACTACTGGC	0.537000													23	54					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48595010	48595010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48595010G>A	ENST00000323776.5	+	4	710	c.548G>A	c.(547-549)gGg>gAg	p.G183E	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.G146E	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	146					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CACATCTTGGGGAGTCTCCAG	0.512000													27	40					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	31010117	31010117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31010117C>T	ENST00000295055.8	-	2	251	c.75G>A	c.(73-75)cgG>cgA	p.R25R	CAPN13_ENST00000465960.2_5'UTR|CAPN13_ENST00000534090.2_Silent_p.R25R	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	25					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GGCAGTGATCCCGCAAGGTGG	0.522000													9	21					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27803388	27803388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27803388G>A	ENST00000408964.2	+	1	4000	c.3949G>A	c.(3949-3951)Gaa>Aaa	p.E1317K		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1317										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					TCCTTCTAGGGAATTAGCAGC	0.398000													13	64					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49001477	49001477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49001477C>T	ENST00000600059.1	-	11	3076	c.2849G>A	c.(2848-2850)gGg>gAg	p.G950E	LMTK3_ENST00000270238.3_Missense_Mutation_p.G979E					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTCGGGGGACCCCAGGGCCCC	0.642000													34	102					0	0	1	0	0
TRBV20-1	28567	broad.mit.edu	37	7	142334236	142334236	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142334236G>A	ENST00000390394.3	+	0	74																											AGGCCATCACGGAAGATGCTG	0.567000											OREG0018395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	28					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581070	234581070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234581070C>T	ENST00000354728.4	+	1	572	c.490C>T	c.(490-492)Ccc>Tcc	p.P164S	UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		TTTCTCCCTCCCCTCCGTGGT	0.433000													69	195					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41452225	41452225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41452225C>T	ENST00000400454.1	-	25	4751	c.4274G>A	c.(4273-4275)gGg>gAg	p.G1425E		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1425	Fibronectin type-III 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGAAAACTCCCCCACTGCTC	0.473000													12	56					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91779837	91779837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91779837G>A	ENST00000389857.6	-	15	2409	c.2323C>T	c.(2323-2325)Ctg>Ttg	p.L775L		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	775					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTGCTCTCCAGGCTCTGCTGC	0.662000													12	21					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67943846	67943846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:67943846C>T	ENST00000252336.6	+	13	3209	c.2837C>T	c.(2836-2838)cCg>cTg	p.P946L	STARD8_ENST00000374597.3_Missense_Mutation_p.P946L|STARD8_ENST00000374599.3_Missense_Mutation_p.P1026L	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	946	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						TCCCTGGATCCGGAACAACCT	0.607000													24	23					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18725439	18725439	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18725439G>A	ENST00000440756.2	-	4	1481	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F	PSD3_ENST00000327040.8_Missense_Mutation_p.S460F|PSD3_ENST00000523619.1_Missense_Mutation_p.S395F			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	460					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TGTCTCCAGGGACTCTGCACT	0.458000													42	91					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493706	55493706	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55493706C>T	ENST00000543010.1	+	6	783	c.640C>T	c.(640-642)Cct>Tct	p.P214S	NLRP2_ENST00000339757.7_Missense_Mutation_p.P192S|NLRP2_ENST00000391721.4_Missense_Mutation_p.P190S|NLRP2_ENST00000427260.2_Missense_Mutation_p.P191S|NLRP2_ENST00000538819.1_Missense_Mutation_p.P190S|NLRP2_ENST00000263437.6_Missense_Mutation_p.P211S|NLRP2_ENST00000537859.1_Missense_Mutation_p.P192S|NLRP2_ENST00000448584.2_Missense_Mutation_p.P214S	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	214	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GCTGTATGGTCCTGCAGGCCT	0.532000													29	76					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101818648	101818648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:101818648C>T	ENST00000375001.3	+	35	3722	c.3299C>T	c.(3298-3300)cCc>cTc	p.P1100L		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1100	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CCACCGGGGCCCCCGGGGCCA	0.627000													13	65					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37282783	37282783	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:37282783G>A	ENST00000373091.3	-	13	1985	c.1969C>T	c.(1969-1971)Ctg>Ttg	p.L657L	GRIK3_ENST00000373093.4_Silent_p.L657L	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	657					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AAGGCAGCCAGGTTGGCCGTG	0.552000													36	57					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2939141	2939141	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2939141G>A	ENST00000378404.2	+	1	1096	c.891G>A	c.(889-891)ggG>ggA	p.G297G		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	297						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		TCCTCTTTGGGGAGATTGTGC	0.607000													35	90					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12203533	12203533	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12203533G>A	ENST00000432424.2	+	0	1031							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AAACCACTACGACTTCCAGGA	0.527000													21	29					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65621371	65621371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65621371G>A	ENST00000327987.4	-	14	2572	c.2321C>T	c.(2320-2322)gCt>gTt	p.A774V		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	774										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GGCGCAGGGAGCCGTGGCCTC	0.711000													17	13					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137928454	137928454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:137928454G>A	ENST00000409968.1	+	7	1847	c.1669G>A	c.(1669-1671)Gga>Aga	p.G557R	THSD7B_ENST00000272643.3_Missense_Mutation_p.G557R|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000413152.2_Missense_Mutation_p.G526R|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B									p.G526R(1)|p.G557R(1)		NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCCTGATCATGGAAAATGTGG	0.522000													13	31					0	0	1	0	0
SLC35G1	159371	broad.mit.edu	37	10	95660749	95660749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95660749C>T	ENST00000371408.3	+	3	658	c.597C>T	c.(595-597)atC>atT	p.I199I	SLC35G1_ENST00000427197.1_Silent_p.I200I			Q2M3R5	TMM20_HUMAN	solute carrier family 35, member G1	200	DUF6 1.					integral to membrane											TGATCCTTATCGTGAGACCAC	0.448000													22	54					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774549	40774549	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:40774549G>A	ENST00000602553.1	-	5	1020	c.726C>T	c.(724-726)tcC>tcT	p.S242S	ZNF658_ENST00000377626.3_Silent_p.S242S|ZNF658_ENST00000441795.1_Silent_p.S240S			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CATCCTTACAGGACTTTTCTC	0.328000													24	93					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123556375	123556375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:123556375G>A	ENST00000422452.2	-	24	4281	c.4218C>T	c.(4216-4218)atC>atT	p.I1406I	TENM1_ENST00000371130.3_Silent_p.I1399I|STAG2_ENST00000469481.1_3'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GGCGTCCTGCGATGATCCGAA	0.498000													40	40					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41804342	41804342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41804342C>T	ENST00000263800.6	-	4	577	c.481G>A	c.(481-483)Ggg>Agg	p.G161R	LTK_ENST00000355166.5_Missense_Mutation_p.G161R|LTK_ENST00000453182.2_Missense_Mutation_p.G161R|LTK_ENST00000561619.1_Intron	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	161					apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CCCTGCTGCCCCACCAGGATG	0.726000										TSP Lung(18;0.14)			10	29					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107314668	107314668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107314668G>A	ENST00000265715.3	+	5	699	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	159					regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GGCCCCCGACGAACACTTTCT	0.433000									Pendred syndrome				41	110					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22039149	22039149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22039149C>T	ENST00000406385.1	+	10	721	c.661C>T	c.(661-663)Ctg>Ttg	p.L221L	PPIL2_ENST00000492445.2_Silent_p.L221L|PPIL2_ENST00000412327.1_Silent_p.L221L|PPIL2_ENST00000456792.2_Silent_p.L200L|PPIL2_ENST00000398831.3_Silent_p.L221L|PPIL2_ENST00000335025.7_Silent_p.L221L			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	221					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					GGACGAGATTCTGGCAGCCAC	0.562000													24	39					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105609479	105609479	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105609479G>A	ENST00000331782.3	-	26	3673	c.3270C>T	c.(3268-3270)gcC>gcT	p.A1090A	JAG2_ENST00000347004.2_Silent_p.A1052A	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	1090					auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		GCACGCTGAAGGCACCACACA	0.692000													19	37					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2416007	2416007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2416007G>A	ENST00000449969.1	+	5	846	c.685G>A	c.(685-687)Gac>Aac	p.D229N	PLCH2_ENST00000288766.5_Intron|PLCH2_ENST00000378488.3_Missense_Mutation_p.D256N|PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000419816.2_Missense_Mutation_p.D256N|PLCH2_ENST00000378486.3_Missense_Mutation_p.D256N			O75038	PLCH2_HUMAN	phospholipase C, eta 2	256	EF-hand 2.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CAACCACAAGGACCACCTGGA	0.622000													17	44					0	0	1	0	0
SERGEF	26297	broad.mit.edu	37	11	18026017	18026017	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18026017G>A	ENST00000265965.5	-	4	569	c.418C>T	c.(418-420)Cga>Tga	p.R140*	RP1-59M18.2_ENST00000525523.1_RNA|SERGEF_ENST00000532212.1_5'UTR|SERGEF_ENST00000532265.1_Nonsense_Mutation_p.R26*|SERGEF_ENST00000528200.1_Nonsense_Mutation_p.R140*	NM_012139.2	NP_036271.1	Q9UGK8	SRGEF_HUMAN	secretion regulating guanine nucleotide exchange factor	140					negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(5)|lung(5)	12						ACACATCTTCGAGGTCCATGA	0.418000													9	22					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110477352	110477352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:110477352G>A	ENST00000260283.4	-	10	1181	c.897C>T	c.(895-897)ctC>ctT	p.L299L	ARHGAP20_ENST00000528829.1_Silent_p.L263L|ARHGAP20_ENST00000524756.1_Silent_p.L276L|ARHGAP20_ENST00000527598.1_Silent_p.L263L|ARHGAP20_ENST00000533353.1_Silent_p.L273L|ARHGAP20_ENST00000357139.3_Silent_p.L273L	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	299					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCTCTCGGGGGAGCTGTTCCA	0.537000													96	194					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3084090	3084090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3084090G>A	ENST00000397461.1	+	20	2879	c.2495G>A	c.(2494-2496)cGa>cAa	p.R832Q	CNTN4_ENST00000397459.2_Missense_Mutation_p.R504Q|CNTN4_ENST00000418658.1_Missense_Mutation_p.R832Q|CNTN4_ENST00000427331.1_Missense_Mutation_p.R832Q|CNTN4_ENST00000448906.2_Missense_Mutation_p.R504Q|CNTN4-AS1_ENST00000442749.2_RNA|CNTN4_ENST00000358480.3_Missense_Mutation_p.R613Q	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	832	Fibronectin type-III 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AATAGAGGACGAATACAAGGT	0.463000													19	36					0	0	1	0	0
VPS37D	155382	broad.mit.edu	37	7	73085400	73085400	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73085400C>T	ENST00000324941.4	+	4	584	c.450C>T	c.(448-450)gcC>gcT	p.A150A	VPS37D_ENST00000451519.1_Silent_p.A65A	NM_001077621.1	NP_001071089.1	Q86XT2	VP37D_HUMAN	vacuolar protein sorting 37 homolog D (S. cerevisiae)	150	VPS37 C-terminal.				cellular membrane organization|endosome transport|protein transport	late endosome membrane				central_nervous_system(1)|ovary(1)	2		Lung NSC(55;0.0908)|all_lung(88;0.198)				TCCTGCCTGCCTTCCAGCGTG	0.706000													13	28					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9498830	9498830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9498830C>T	ENST00000246070.2	+	5	1111	c.619C>T	c.(619-621)Cac>Tac	p.H207Y	LAMP5_ENST00000427562.2_Missense_Mutation_p.H163Y	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	207						integral to membrane											GTCTGCGGTCCACATCCAACC	0.483000													5	78					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121016411	121016411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121016411C>T	ENST00000392793.1	+	12	3962	c.3691C>T	c.(3691-3693)Cgg>Tgg	p.R1231W	TECTA_ENST00000264037.2_Missense_Mutation_p.R1231W|TECTA_ENST00000478058.1_3'UTR			O75443	TECTA_HUMAN	tectorin alpha	1231	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CACAGTCCCTCGGAGCATGCA	0.507000													30	52					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130407850	130407850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130407850C>T	ENST00000370904.1	-	26	4814	c.3904G>A	c.(3904-3906)Gaa>Aaa	p.E1302K	IGSF1_ENST00000370903.3_Missense_Mutation_p.E1316K|IGSF1_ENST00000370910.1_Missense_Mutation_p.E1302K|IGSF1_ENST00000361420.3_Missense_Mutation_p.E1311K			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1311					regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GGTTCTCCTTCTTGGTTACAC	0.463000													89	48					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36253876	36253876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36253876C>T	ENST00000296604.3	-	12	1525	c.1040G>A	c.(1039-1041)gGc>gAc	p.G347D	RANBP3L_ENST00000502994.1_Missense_Mutation_p.G372D	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	347	RanBD1.				intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CCTTAGACTGCCTTGATTGCG	0.393000													29	76					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2411249	2411249	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2411249C>T	ENST00000288766.5	+	3	622	c.213_splice	c.e3+1	p.F71_splice	PLCH2_ENST00000378488.3_Silent_p.F116F|PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000449969.1_Silent_p.F89F|PLCH2_ENST00000419816.2_Silent_p.F116F|PLCH2_ENST00000378486.3_Silent_p.F116F			O75038	PLCH2_HUMAN	phospholipase C, eta 2	783	Necessary for plasma membrane localization (By similarity).|PH.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		ACGGCAGCTTCGACCCCAACT	0.677000													5	11					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518778	113518778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113518778C>T	ENST00000284601.3	-	4	2437	c.2369G>A	c.(2368-2370)cGa>cAa	p.R790Q		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	790					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TACTGTATCTCGTTGACAAAG	0.398000													19	63					0	0	1	0	0
TRGJP2	6972	broad.mit.edu	37	7	38295943	38295943	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38295943G>A	ENST00000390334.1	-	0	54																											CTTACCAGGCGAAGTTACTAT	0.338000													8	13					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230231657	230231657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230231657C>T	ENST00000341772.4	-	12	2168	c.2034G>A	c.(2032-2034)gaG>gaA	p.E678E		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	678	Interaction with AP1G1 and somatodendritic targeting (By similarity).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGTAGAACTCCTCATAGGCTG	0.582000													22	47					0	0	1	0	0
HMGCL	3155	broad.mit.edu	37	1	24140689	24140689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24140689G>A	ENST00000374483.4	-	6	1084	c.413C>T	c.(412-414)tCt>tTt	p.S138F	HMGCL_ENST00000509389.1_Intron|HMGCL_ENST00000374490.3_Missense_Mutation_p.S163F|HMGCL_ENST00000436439.2_Intron			P35914	HMGCL_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase	163					acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		CCCCCGCACAGAAATATTGGC	0.498000													29	68					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96021270	96021270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96021270C>T	ENST00000297954.4	+	11	2440	c.2440C>T	c.(2440-2442)Cct>Tct	p.P814S	WNK2_ENST00000395475.2_Missense_Mutation_p.P748S|WNK2_ENST00000349097.3_Missense_Mutation_p.P426S|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.P426S|WNK2_ENST00000395477.2_Missense_Mutation_p.P814S			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	814					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CGACGGCCTCCCTCCGGCCCT	0.657000													21	60					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74692164	74692164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74692164C>T	ENST00000334011.5	+	9	1738	c.1520C>T	c.(1519-1521)tCc>tTc	p.S507F		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	507	ZP.					nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					GACGAGCGTTCCCGCTGTGCC	0.582000													56	157					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39974733	39974733	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39974733G>A	ENST00000321562.4	+	4	785	c.681G>A	c.(679-681)agG>agA	p.R227R		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	227	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GAGAGAGAAGGAAGATTATCA	0.557000													9	18					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105905313	105905313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105905313G>A	ENST00000357060.3	-	31	3980	c.3865C>T	c.(3865-3867)Cgc>Tgc	p.R1289C	WDR96_ENST00000428666.1_Missense_Mutation_p.R1261C	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1289										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TTAAAGCTGCGATCCATAACC	0.368000													11	43					0	0	1	0	0
FKBP3	2287	broad.mit.edu	37	14	45603624	45603624	+	Silent	SNP	C	C	T	rs28366026		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:45603624C>T	ENST00000216330.3	-	2	446	c.36G>A	c.(34-36)gtG>gtA	p.V12V	FKBP3_ENST00000396062.3_Silent_p.V12V			Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	12					protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity			NS(1)|biliary_tract(1)|endometrium(1)|large_intestine(2)|lung(6)|skin(1)	12						GCAGCTGCTCCACGGTCCACG	0.662000													21	79					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455864	5455864	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5455864G>T	ENST00000222033.4	+	1	439	c.362G>T	c.(361-363)gGc>gTc	p.G121V		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	121						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GCGCTGTTCGGCGTCCCCCTG	0.682000													18	110					2.89027e-11	2.9022e-11	1	1	0
TSPEAR	54084	broad.mit.edu	37	21	45947202	45947202	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45947202G>A	ENST00000323084.4	-	7	1187	c.1122C>T	c.(1120-1122)gcC>gcT	p.A374A	TSPEAR_ENST00000397916.1_Silent_p.A306A	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	374					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						AATGCCTCCAGGCCTGTGCTT	0.562000													16	96					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64607671	64607671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64607671G>A	ENST00000342711.5	-	5	501	c.502C>T	c.(502-504)Ccg>Tcg	p.P168S		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	168	Protein kinase.		P -> L (in dbSNP:rs34454471).		actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						AGCTCGGGCGGGAGACGGTCC	0.642000													15	38					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30795606	30795606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30795606C>T	ENST00000383096.3	-	19	2168	c.1986G>A	c.(1984-1986)atG>atA	p.M662I	CCDC178_ENST00000406524.2_Missense_Mutation_p.M662I|CCDC178_ENST00000300227.8_Missense_Mutation_p.M624I|CCDC178_ENST00000579947.1_Missense_Mutation_p.M662I|CCDC178_ENST00000402325.1_Missense_Mutation_p.M662I|CCDC178_ENST00000583930.1_Missense_Mutation_p.M662I|CCDC178_ENST00000403303.1_Missense_Mutation_p.M662I|CCDC178_ENST00000579916.1_Intron					coiled-coil domain containing 178									p.M624I(1)|p.M662I(1)									CATAAAAAATCATTGTCTTAC	0.254000													4	33					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18764911	18764911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18764911G>A	ENST00000358540.2	-	5	787	c.357C>T	c.(355-357)ctC>ctT	p.L119L	PTPN5_ENST00000396170.1_Intron|PTPN5_ENST00000396171.4_Silent_p.L119L|PTPN5_ENST00000396167.2_Intron|PTPN5_ENST00000477854.1_5'UTR|PTPN5_ENST00000496201.2_5'UTR|PTPN5_ENST00000396168.1_Silent_p.L95L	NM_006906.1	NP_008837.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	119						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						AAGAGGAGACGAGGTTTGTGG	0.592000													74	46					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186008003	186008003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186008003C>T	ENST00000271588.4	+	38	6123	c.5894C>T	c.(5893-5895)aCc>aTc	p.T1965I	HMCN1_ENST00000367492.2_Missense_Mutation_p.T1965I	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1965	Ig-like C2-type 17.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCAGGTTCCACCAGCATGACT	0.368000													50	123					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561502	145561502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145561502C>T	ENST00000355594.4	+	10	1277	c.1190C>T	c.(1189-1191)cCa>cTa	p.P397L		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	397										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACAGTAAATCCAGTATTAGCT	0.552000													18	54					0	0	1	0	0
YAE1D1	57002	broad.mit.edu	37	7	39611996	39611996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:39611996C>T	ENST00000223273.2	+	3	415	c.372C>T	c.(370-372)atC>atT	p.I124I	YAE1D1_ENST00000432096.2_Intron|YAE1D1_ENST00000448268.1_3'UTR	NM_020192.3	NP_064577.1	Q9NRH1	CG036_HUMAN	Yae1 domain containing 1	124																	TGAAATCAATCACTCCACCGT	0.368000													22	93					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6750866	6750866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6750866G>A	ENST00000378827.4	+	2	1312	c.93G>A	c.(91-93)agG>agA	p.R31R		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	31					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	TGGGCCGCAGGAAGTTCGCGG	0.692000													6	8					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66928483	66928483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66928483C>T	ENST00000269080.2	-	6	880	c.743G>A	c.(742-744)aGg>aAg	p.R248K	ABCA8_ENST00000586539.1_Missense_Mutation_p.R248K|ABCA8_ENST00000430352.2_Missense_Mutation_p.R248K	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	248						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					CATCCTTTTCCTCTCTCTTGT	0.388000													23	41					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475717	120475717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:120475717G>A	ENST00000355622.6	+	3	1412	c.1311G>A	c.(1309-1311)atG>atA	p.M437I	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.M397I	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	437					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TGAAACAAATGAGTGAGTTTT	0.378000													20	77					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96952165	96952165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96952165G>A	ENST00000323853.5	-	29	3964	c.3887C>T	c.(3886-3888)cCc>cTc	p.P1296L	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1296						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						GGTTGGAGGGGGGTACTTCTC	0.498000													33	101					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88258513	88258513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88258513C>T	ENST00000418177.2	-	9	3057	c.2690G>A	c.(2689-2691)gGg>gAg	p.G897E	GRM5_ENST00000455756.2_Intron|GRM5_ENST00000305447.4_Missense_Mutation_p.G897E|GRM5_ENST00000393297.1_Intron|GRM5_ENST00000305432.5_Intron			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	897					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CCCCATACTCCCTTTGGGGGT	0.483000													116	304					0	0	1	0	0
ANKRD6	22881	broad.mit.edu	37	6	90340157	90340157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:90340157G>A	ENST00000369408.5	+	15	1862	c.1513G>A	c.(1513-1515)Gac>Aac	p.D505N	ANKRD6_ENST00000447838.2_Missense_Mutation_p.D535N|LYRM2_ENST00000520441.1_Intron|ANKRD6_ENST00000339746.4_Missense_Mutation_p.D540N|ANKRD6_ENST00000520793.1_Missense_Mutation_p.D476N|ANKRD6_ENST00000522441.1_Missense_Mutation_p.D540N	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	540							protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		ACCAGGTGTGGACCAATTAGT	0.507000													14	26					0	0	1	0	0
B3GALTL	145173	broad.mit.edu	37	13	31835147	31835147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:31835147C>T	ENST00000343307.4	+	7	673	c.524C>T	c.(523-525)tCc>tTc	p.S175F	B3GALTL_ENST00000461652.2_3'UTR	NM_194318.3	NP_919299.3	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	175					fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		TATGCCTTTTCCGAGAATCCT	0.343000													14	58					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71825461	71825461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:71825461G>A	ENST00000373545.3	-	23	2876	c.2438C>T	c.(2437-2439)cCc>cTc	p.P813L	PHKA1_ENST00000541944.1_Missense_Mutation_p.P813L|PHKA1_ENST00000373539.3_Missense_Mutation_p.P872L|PHKA1_ENST00000339490.3_Missense_Mutation_p.P872L|PHKA1_ENST00000373542.4_Missense_Mutation_p.P872L			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	872	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CGCCTCATAGGGCAGAGGTCT	0.393000													15	17					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157528825	157528825	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:157528825C>T	ENST00000346085.5	+	20	6551	c.6550C>T	c.(6550-6552)Ccc>Tcc	p.P2184S	ARID1B_ENST00000275248.4_Missense_Mutation_p.P2166S|ARID1B_ENST00000367148.1_Missense_Mutation_p.P2224S|ARID1B_ENST00000350026.5_Missense_Mutation_p.P2171S	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2171					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity	p.P2168fs*6(1)		NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GCACATGCAGCCCCCGCCCCT	0.557000													35	52					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81769583	81769583	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81769583G>A	ENST00000550584.2	-	9	1418	c.1123C>T	c.(1123-1125)Ctg>Ttg	p.L375L	PPFIA2_ENST00000549396.1_Silent_p.L375L|PPFIA2_ENST00000548586.1_Silent_p.L375L|PPFIA2_ENST00000552948.1_Silent_p.L375L|PPFIA2_ENST00000545296.2_5'UTR|PPFIA2_ENST00000549325.1_Silent_p.L357L|PPFIA2_ENST00000550359.2_Silent_p.L222L|PPFIA2_ENST00000407050.4_Silent_p.L301L|PPFIA2_ENST00000333447.7_Silent_p.L357L|PPFIA2_ENST00000443686.3_Silent_p.L276L	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	301										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ACCTGCCGCAGGATAGCTTCT	0.398000													11	27					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7581550	7581550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7581550C>T	ENST00000379802.3	+	23	5468	c.5127C>T	c.(5125-5127)ctC>ctT	p.L1709L	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1709	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGCAGTCTCTCACAGAGAACC	0.463000													18	125					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31541429	31541429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31541429C>T	ENST00000454783.1	+	4	835	c.577C>T	c.(577-579)Ctc>Ttc	p.L193F	LTA_ENST00000418386.2_Missense_Mutation_p.L193F	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	193					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	CCACCTAGTCCTCAGCCCTAG	0.522000													79	186					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590670	156590670	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156590670C>T	ENST00000302938.4	-	2	702		c.e2-1			NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B							nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCTCTGCAGCCTATACCAAGG	0.483000													32	70					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44146425	44146425	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44146425C>T	ENST00000223357.3	+	2	839	c.534C>T	c.(532-534)acC>acT	p.T178T		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	178	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						CCTCAGAAACCCTGGAGTGGC	0.667000													8	21					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84243513	84243513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:84243513G>A	ENST00000405413.2	-	3	368	c.232C>T	c.(232-234)Cca>Tca	p.P78S	HPSE_ENST00000311412.5_Missense_Mutation_p.P78S|HPSE_ENST00000513463.1_Missense_Mutation_p.P78S|HPSE_ENST00000512196.1_Missense_Mutation_p.P78S	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	78					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	CGAAGCTTTGGAGAACTGTTA	0.423000													12	21					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88476386	88476386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:88476386C>T	ENST00000394480.1	-	16	2067	c.1746G>A	c.(1744-1746)cgG>cgA	p.R582R	NTRK3_ENST00000542733.2_Silent_p.R484R|NTRK3_ENST00000355254.2_Silent_p.R582R|NTRK3_ENST00000357724.2_Silent_p.R574R|NTRK3_ENST00000558676.1_Silent_p.R574R|NTRK3_ENST00000360948.2_Silent_p.R582R|NTRK3_ENST00000557856.1_Silent_p.R574R	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	582	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGAAATCCTTCCGGGCAGCCA	0.567000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			51	49					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109513549	109513549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:109513549C>T	ENST00000409271.1	-	12	1700	c.1257G>A	c.(1255-1257)gaG>gaA	p.E419E	EDAR_ENST00000376651.1_Silent_p.E419E|EDAR_ENST00000258443.2_Silent_p.E387E			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	387	Death.				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TGCCCCCAATCTCATCCCTCT	0.562000													11	44					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662562	662562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:662562C>T	ENST00000266383.5	+	14	1486	c.1473C>T	c.(1471-1473)tcC>tcT	p.S491S		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	491						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			CCCCCTTCTCCAAGCGGAACT	0.642000													9	91					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584156	179584156	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179584156G>A	ENST00000589042.1	-	83	24185	c.23961C>T	c.(23959-23961)ttC>ttT	p.F7987F	TTN_ENST00000342992.6_Silent_p.F6743F|TTN_ENST00000591111.1_Silent_p.F7670F|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7670	Ig-like 62.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTGCGGATGAAGGAAGGAG	0.502000													24	85					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072414	9072414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9072414G>A	ENST00000397910.4	-	3	15235	c.15032C>T	c.(15031-15033)tCa>tTa	p.S5011L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5013	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATCCAATTGTGAAAATCCATG	0.483000													9	71					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103142759	103142759	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103142759G>A	ENST00000295269.4	+	11	2449	c.1992G>A	c.(1990-1992)ggG>ggA	p.G664G		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	664					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						ACCCCTACGGGAATCCTCAGT	0.502000													38	92					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164506928	164506928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164506928C>T	ENST00000503008.1	-	6	1372	c.396G>A	c.(394-396)atG>atA	p.M132I	MARCH1_ENST00000274056.7_Missense_Mutation_p.M132I|MARCH1_ENST00000514618.1_Missense_Mutation_p.M388I|MARCH1_ENST00000339875.5_Missense_Mutation_p.M115I	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	132					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GCTTGGTCTCCATTATGAAGT	0.483000													35	80					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107423262	107423262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107423262C>T	ENST00000409382.3	-	6	2072	c.1462G>A	c.(1462-1464)Gag>Aag	p.E488K	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.E488K	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	488					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						AGGAGCTTCTCATAGAGTAGT	0.617000													24	65					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13381426	13381426	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13381426G>A	ENST00000254508.5	-	25	3481	c.3399C>T	c.(3397-3399)atC>atT	p.I1133I	NUP210_ENST00000485755.1_5'UTR	NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1133					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TGCCGTTCCCGATGGCGAGGC	0.622000													44	157					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7709559	7709559	+	Silent	SNP	C	C	T	rs139160342	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7709559C>T	ENST00000441779.2	+	14	1237	c.1200C>T	c.(1198-1200)atC>atT	p.I400I	STXBP2_ENST00000221283.5_Silent_p.I389I|STXBP2_ENST00000414284.2_Silent_p.I386I	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	389					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						TGAAGCTGATCGTTCCGGTGC	0.657000													22	47					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832220	61832220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61832220C>T	ENST00000280772.1	-	37	8610	c.8419G>A	c.(8419-8421)Gat>Aat	p.D2807N	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2807					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTCACATTATCAGAGCCAGAA	0.373000													36	78					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22872489	22872489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22872489C>T	ENST00000283645.4	+	22	3148	c.3018C>T	c.(3016-3018)tcC>tcT	p.S1006S	TUBGCP5_ENST00000453949.2_Silent_p.S1006S	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	1006					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GTAGAGGATCCTTTCCCCATT	0.323000													26	115					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149879672	149879672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149879672C>T	ENST00000369146.3	-	9	1956	c.1466G>A	c.(1465-1467)gGg>gAg	p.G489E	SV2A_ENST00000369145.1_Missense_Mutation_p.G489E	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	489					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TACGCGCTCCCCGGGGAACAC	0.517000													49	134					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160482654	160482654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:160482654C>T	ENST00000356956.1	+	24	3530	c.3382C>T	c.(3382-3384)Ctc>Ttc	p.L1128F		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1128					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TTGCAATCCTCTCCCTTACAT	0.493000													47	58					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78933433	78933433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78933433G>A	ENST00000261751.3	-	1	154	c.43C>T	c.(43-45)Ctt>Ttt	p.L15F	CHRNB4_ENST00000412074.2_Missense_Mutation_p.L15F|CHRNB4_ENST00000560511.1_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	15					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CGCCCGCAAAGGGCGACCAGG	0.711000													7	16					0	0	1	0	0
GCM1	8521	broad.mit.edu	37	6	52999086	52999086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:52999086C>T	ENST00000259803.7	-	3	323	c.112G>A	c.(112-114)Gat>Aat	p.D38N		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	38						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					GCATAGGAATCTGGCCACTCC	0.493000													9	107					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495547	71495547	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71495547C>T	ENST00000296755.7	+	5	6663	c.6365C>T	c.(6364-6366)cCc>cTc	p.P2122L		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2122						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TCTGAAAAGCCCCTCACTCAA	0.542000													58	129					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881273	142881273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142881273G>A	ENST00000446620.1	+	1	762	c.762G>A	c.(760-762)atG>atA	p.M254I		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	254					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					ACCCCAGCATGGAGGCTCACA	0.488000													38	126					0	0	1	0	0
ALG10B	144245	broad.mit.edu	37	12	38714175	38714175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:38714175C>T	ENST00000308742.4	+	3	898	c.582C>T	c.(580-582)gtC>gtT	p.V194V	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	194					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TCTGGGCTGTCTTCTGTGCAG	0.388000													45	287					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161013	90161013	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:90161013C>T	ENST00000567960.1	+	0	243				TUBB8P7_ENST00000564451.1_RNA																							CGGGGCCCTTCGGGCAGGTCT	0.667000													24	61					0	0	1	0	0
CLDN10	9071	broad.mit.edu	37	13	96205054	96205054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:96205054C>T	ENST00000299339.2	+	1	76	c.47C>T	c.(46-48)tCa>tTa	p.S16L	CLDN10_ENST00000376873.3_Intron	NM_006984.4	NP_008915.1	P78369	CLD10_HUMAN	claudin 10	16					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			GTCTCCATCTCAGGCTGGGTA	0.652000													12	33					0	0	1	0	0
MMD	23531	broad.mit.edu	37	17	53488740	53488740	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:53488740G>A	ENST00000262065.3	-	3	443	c.147C>T	c.(145-147)ctC>ctT	p.L49L		NM_012329.2	NP_036461.2	Q15546	PAQRB_HUMAN	monocyte to macrophage differentiation-associated	49					cytolysis	integral to plasma membrane|late endosome membrane|lysosomal membrane|membrane fraction	receptor activity			breast(1)|large_intestine(1)|lung(4)|prostate(1)	7						ACAGCCGATGGAGGAGGGCAC	0.438000													8	48					0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101718929	101718929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101718929G>A	ENST00000318607.5	-	11	2680	c.1552C>T	c.(1552-1554)Cgc>Tgc	p.R518C	PABPC1_ENST00000519004.1_Missense_Mutation_p.R473C|PABPC1_ENST00000519596.1_5'UTR|PABPC1_ENST00000522387.1_Missense_Mutation_p.R486C	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	518					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			TGAGGATTGCGAACTCCTGCA	0.453000													36	74					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77257578	77257578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77257578C>T	ENST00000376896.2	+	4	1096	c.484C>T	c.(484-486)Cag>Tag	p.Q162*	RORB_ENST00000396204.2_Nonsense_Mutation_p.Q173*	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	173	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.Q162*(1)		breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						CGATTCCGGTCAGCCGTCCCC	0.507000													18	32					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57194407	57194407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57194407C>T	ENST00000331162.4	-	3	328	c.58G>A	c.(58-60)Gac>Aac	p.D20N		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			ATAGCTATGTCTCTGAATGTC	0.413000													11	94					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19748171	19748171	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:19748171G>A	ENST00000400113.3	-	5	1289	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	395					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ACATGAGATCGAACTTATGGT	0.642000													57	158					0	0	1	0	0
UPK3A	7380	broad.mit.edu	37	22	45685012	45685012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45685012C>T	ENST00000216211.4	+	4	591	c.559C>T	c.(559-561)Cgc>Tgc	p.R187C	UPK3A_ENST00000396082.2_Intron	NM_006953.3	NP_008884.1	O75631	UPK3A_HUMAN	uroplakin 3A	187					epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane				kidney(1)|large_intestine(1)|lung(2)|skin(1)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		AGACCCCATCCGCACCAACCA	0.602000													18	97					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277031	152277031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152277031C>T	ENST00000368799.1	-	3	10366	c.10331G>A	c.(10330-10332)gGa>gAa	p.G3444E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3444	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCCTGCCTTCCTCTTCTGCT	0.602000									Ichthyosis				162	415					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43439744	43439744	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43439744G>A	ENST00000446844.3	-	0	331				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TACTATATATGATGTAACATA	0.423000													88	329					0	0	1	0	0
MSI1	4440	broad.mit.edu	37	12	120785268	120785268	+	Silent	SNP	C	C	T	rs141481855	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120785268C>T	ENST00000257552.2	-	12	928	c.840G>A	c.(838-840)gcG>gcA	p.A280A		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	280	Poly-Ala.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAACCACAGCCGCTGCCGCCG	0.627000													35	173					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65396366	65396366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65396366C>T	ENST00000355703.3	+	24	4427	c.3888C>T	c.(3886-3888)gcC>gcT	p.A1296A		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1296						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						TAGGCAGTGCCGTCTTCATCA	0.632000													11	24					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102964547	102964547	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102964547G>A	ENST00000233954.1	+	9	1384	c.1113G>A	c.(1111-1113)agG>agA	p.R371R		NM_016232.4	NP_057316.3	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	371					innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						ACAAGACTAGGAATGGTAAGT	0.378000													30	50					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34052145	34052145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34052145C>T	ENST00000373381.4	-	46	7186	c.7010G>A	c.(7009-7011)gGa>gAa	p.G2337E		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2339	Sushi 13.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CAGGTAGGTTCCAAGTTTGCA	0.488000													17	67					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42915959	42915959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42915959C>T	ENST00000316161.4	-	1	1674	c.1350G>A	c.(1348-1350)gtG>gtA	p.V450V	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Intron|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	450					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		TAAAGAGCTTCACCTCACTGA	0.537000													25	48					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169819815	169819815	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169819815G>A	ENST00000335742.7	+	14	3254	c.1897G>A	c.(1897-1899)Gga>Aga	p.G633R	PALLD_ENST00000261509.6_Missense_Mutation_p.G791R|PALLD_ENST00000507735.1_Missense_Mutation_p.G304R|PALLD_ENST00000512127.1_Missense_Mutation_p.G409R|CBR4_ENST00000509108.1_Intron|PALLD_ENST00000505667.1_Missense_Mutation_p.G808R			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	1015					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GATCTTTGAGGGAATGCCAGT	0.433000									Pancreatic Cancer, Familial Clustering of				19	75					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22890763	22890763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22890763G>A	ENST00000543184.1	-	5	2118	c.1256C>T	c.(1255-1257)tCc>tTc	p.S419F	PRAME_ENST00000398743.2_Missense_Mutation_p.S419F|PRAME_ENST00000402697.1_Missense_Mutation_p.S419F|PRAME_ENST00000398741.1_Missense_Mutation_p.S419F|PRAME_ENST00000405655.3_Missense_Mutation_p.S419F|PRAME_ENST00000539862.1_Missense_Mutation_p.S403F|PRAME_ENST00000424204.2_Missense_Mutation_p.S403F	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	419	Mediates interaction with RARA.				apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		GGCAGATATGGAGATGGAATT	0.547000													17	49					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885275	88885275	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:88885275C>T	ENST00000319675.3	-	1	1021	c.925G>A	c.(925-927)Gaa>Aaa	p.E309K		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	309										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						ACATGACCTTCGTACTGTGTT	0.517000													13	71					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690528	33690528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33690528C>T	ENST00000394566.1	-	4	571	c.299G>A	c.(298-300)gGa>gAa	p.G100E	SLFN11_ENST00000308377.4_Missense_Mutation_p.G100E	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	100						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAAACACCTTCCTTGTTGCTT	0.458000													19	58					0	0	1	0	0
DOK5	55816	broad.mit.edu	37	20	53205055	53205055	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:53205055C>T	ENST00000262593.5	+	3	558	c.208C>T	c.(208-210)Cga>Tga	p.R70*	DOK5_ENST00000395939.1_5'UTR	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	70	PH.						insulin receptor binding	p.R70G(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			GAACGTAGCTCGATTGCCAAA	0.408000													59	133					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57865804	57865804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57865804C>T	ENST00000228682.2	+	12	3372	c.3281C>T	c.(3280-3282)tCc>tTc	p.S1094F	GLI1_ENST00000546141.1_Missense_Mutation_p.S1053F|GLI1_ENST00000543426.1_Missense_Mutation_p.S966F	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	1094					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding	p.S1094F(2)		NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			TTACTGAGATCCCTACCTGGG	0.532000													30	94					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68912536	68912536	+	Silent	SNP	G	G	A	rs146357166	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:68912536G>A	ENST00000262340.5	-	3	155	c.102C>T	c.(100-102)atC>atT	p.I34I		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	34					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						GCCAGAGGGGGATCCTGCCTG	0.542000													21	68					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152787119	152787119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152787119G>A	ENST00000367255.5	-	17	2328	c.1727C>T	c.(1726-1728)tCa>tTa	p.S576L	SYNE1_ENST00000466159.2_Missense_Mutation_p.S576L|SYNE1_ENST00000413186.2_Missense_Mutation_p.S576L|SYNE1_ENST00000448038.1_Missense_Mutation_p.S583L|SYNE1_ENST00000367253.4_Missense_Mutation_p.S576L|SYNE1_ENST00000367248.3_Missense_Mutation_p.S566L|SYNE1_ENST00000423061.1_Missense_Mutation_p.S583L|SYNE1_ENST00000265368.4_Missense_Mutation_p.S576L|SYNE1_ENST00000341594.5_Missense_Mutation_p.S583L|SYNE1_ENST00000495090.2_Missense_Mutation_p.S143L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	576					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGTTTTACCTGAACCATCTGC	0.373000										HNSCC(10;0.0054)			22	27					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33585816	33585816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33585816G>A	ENST00000404816.2	+	27	4506	c.4153G>A	c.(4153-4155)Gaa>Aaa	p.E1385K	LTBP1_ENST00000404525.1_Missense_Mutation_p.E1006K|LTBP1_ENST00000402934.1_Missense_Mutation_p.E1004K|LTBP1_ENST00000272273.5_Missense_Mutation_p.E283K|LTBP1_ENST00000390003.4_Missense_Mutation_p.E1060K|LTBP1_ENST00000418533.2_Missense_Mutation_p.E1017K|LTBP1_ENST00000407925.1_Missense_Mutation_p.E1059K|LTBP1_ENST00000354476.3_Missense_Mutation_p.E1386K			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1385	TB 3.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGATAACTGCGAAATCTTCCC	0.498000													5	74					0	0	1	0	0
TMEM40	55287	broad.mit.edu	37	3	12780058	12780058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12780058C>T	ENST00000314124.7	-	6	741	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K	TMEM40_ENST00000431022.2_Missense_Mutation_p.E145K|TMEM40_ENST00000476331.1_5'UTR|TMEM40_ENST00000435575.1_Missense_Mutation_p.E53K|TMEM40_ENST00000264728.8_Missense_Mutation_p.E129K|TMEM40_ENST00000435218.2_Missense_Mutation_p.E99K	NM_018306.2	NP_060776.2	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	129						integral to membrane				breast(1)|large_intestine(3)|lung(5)|urinary_tract(1)	10						TCACCTGATTCCCCAGAGGGT	0.547000													36	102					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116339546	116339546	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:116339546C>T	ENST00000397752.3	+	2	608	c.408C>T	c.(406-408)gtC>gtT	p.V136V	MET_ENST00000318493.6_Silent_p.V136V|MET_ENST00000436117.2_Silent_p.V136V	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	136	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			GTGGCAGCGTCAACAGAGGGA	0.473000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				17	174					0	0	1	0	0
KRT23	25984	broad.mit.edu	37	17	39092585	39092585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39092585G>A	ENST00000209718.3	-	2	695	c.271C>T	c.(271-273)Cgc>Tgc	p.R91C	AC004231.2_ENST00000418393.1_RNA|KRT23_ENST00000436344.3_Intron	NM_015515.3	NP_056330.3	Q9C075	K1C23_HUMAN	keratin 23 (histone deacetylase inducible)	91	Coil 1A.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000301)|Ovarian(249;0.15)				TCCAGGGCGCGAACCTTCTCC	0.557000													55	98					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039058	11039058	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039058C>T	ENST00000470054.1	-	0	1145									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCATCAATCCAGTAGAAAGT	0.398000													71	706					0	0	1	0	0
CSNK2A3	283106	broad.mit.edu	37	11	11373680	11373680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:11373680C>T	ENST00000528848.2	-	1	1224	c.987G>A	c.(985-987)aaG>aaA	p.K329K	GALNT18_ENST00000227756.4_Intron	NM_001256686.1	NP_001243615.1			casein kinase 2, alpha 3 polypeptide																		GAGCCTGGTCCTTCACAACAG	0.542000													25	96					0	0	1	0	0
CALML3	810	broad.mit.edu	37	10	5567368	5567368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5567368G>A	ENST00000315238.1	+	1	445	c.320G>A	c.(319-321)cGa>cAa	p.R107Q	CALML3-AS1_ENST00000542093.1_RNA|CALML3-AS1_ENST00000545372.1_RNA|RP11-116G8.5_ENST00000442008.2_RNA	NM_005185.2	NP_005176.1	P27482	CALL3_HUMAN	calmodulin-like 3	107	EF-hand 3.						calcium ion binding			endometrium(3)|lung(2)	5						GCCGAGCTGCGACACGTCATG	0.647000													17	31					0	0	1	0	0
WDR86	349136	broad.mit.edu	37	7	151097249	151097249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151097249C>T	ENST00000334493.6	-	2	672	c.242G>A	c.(241-243)aGg>aAg	p.R81K	WDR86_ENST00000469830.2_Missense_Mutation_p.R81K|WDR86_ENST00000477459.1_5'UTR	NM_198285.2	NP_938026.2	Q86TI4	WDR86_HUMAN	WD repeat domain 86	81										breast(1)|endometrium(2)|kidney(1)|lung(6)	10			OV - Ovarian serous cystadenocarcinoma(82;0.00419)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACGTCCCACCTCCTGATGGT	0.607000													6	15					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131186710	131186710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:131186710G>A	ENST00000337057.3	-	17	2976	c.2795C>T	c.(2794-2796)tCc>tTc	p.S932F	EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000528282.1_Missense_Mutation_p.S674F|EPB41L2_ENST00000525193.1_Missense_Mutation_p.S633F|EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000527659.1_Missense_Mutation_p.S738F|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000445890.2_Missense_Mutation_p.S674F|EPB41L2_ENST00000368128.2_Missense_Mutation_p.S932F|EPB41L2_ENST00000527411.1_Missense_Mutation_p.S862F|EPB41L2_ENST00000530481.1_Missense_Mutation_p.S779F|EPB41L2_ENST00000531410.1_Missense_Mutation_p.S53F|EPB41L2_ENST00000529208.1_Missense_Mutation_p.S862F|EPB41L2_ENST00000524581.1_Missense_Mutation_p.S310F	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	932	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity	p.S932F(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TGTTGACACGGACTCAGATGT	0.458000													19	48					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6062203	6062203	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6062203C>T	ENST00000409021.3	-	11	2041	c.1592G>A	c.(1591-1593)aGg>aAg	p.R531K	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.R366K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.R531K|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.R346K|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.R531K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	531	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GGCCTGACACCTCAGCAGATC	0.527000													37	129					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57771017	57771017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57771017C>T	ENST00000371030.2	+	2	3832	c.3832C>T	c.(3832-3834)Cgt>Tgt	p.R1278C		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1278						intracellular	nucleic acid binding|zinc ion binding	p.R1278C(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AAAGATGTCTCGTGGGAACAG	0.498000													36	147					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123596828	123596828	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123596828G>A	ENST00000336139.4	-	8	2186	c.1824C>T	c.(1822-1824)ctC>ctT	p.L608L	ZNF202_ENST00000529691.1_Silent_p.L608L|ZNF202_ENST00000530393.1_Silent_p.L608L			O95125	ZN202_HUMAN	zinc finger protein 202	608					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		GATGCCTGACGAGGTGGTCCC	0.552000													28	81					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107022182	107022182	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:107022182A>T	ENST00000369701.3	+	26	3764	c.3537A>T	c.(3535-3537)aaA>aaT	p.K1179N		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1179						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACGCCCCCAAAATCACACTCA	0.507000													21	52					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52682524	52682524	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52682524G>A	ENST00000355568.4	-	8	623	c.484C>T	c.(484-486)Cga>Tga	p.R162*		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	162	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity	p.R219*(1)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		ATACAAGTTCGAGCAAGTTCC	0.333000													33	65					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55912417	55912417	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:55912417G>A	ENST00000389286.4	-	20	3293	c.3246C>T	c.(3244-3246)acC>acT	p.T1082T		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	1082					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TTAATACAGTGGTGCCTGGCT	0.468000													32	87					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186445088	186445088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186445088G>A	ENST00000265023.4	+	5	839	c.627G>A	c.(625-627)gaG>gaA	p.E209E	RP11-573D15.8_ENST00000599314.1_RNA|KNG1_ENST00000447445.1_Intron|KNG1_ENST00000287611.2_Silent_p.E209E	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	209	Cystatin 2.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GTTCCAAAGAGAATTTTCTGT	0.343000													10	107					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163302789	163302789	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163302789G>A	ENST00000332142.5	-	7	1392	c.1293C>T	c.(1291-1293)ttC>ttT	p.F431F	KCNH7_ENST00000328032.4_Silent_p.F424F	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	431					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CATTGAGGAGGAAGGCTGCAG	0.423000													24	64					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54930377	54930377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54930377C>T	ENST00000301194.4	+	2	324	c.202C>T	c.(202-204)Cgc>Tgc	p.R68C	TTYH1_ENST00000376530.3_Missense_Mutation_p.R68C|TTYH1_ENST00000376531.3_Missense_Mutation_p.R68C|TTYH1_ENST00000391739.3_Missense_Mutation_p.R117C			Q9H313	TTYH1_HUMAN	tweety family member 1	68					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		CTACCTCATCCGCTTCTGCTG	0.687000													35	97					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111078277	111078277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111078277C>T	ENST00000551590.1	+	8	1089	c.933C>T	c.(931-933)ctC>ctT	p.L311L	TCTN1_ENST00000397655.3_Silent_p.L297L|TCTN1_ENST00000377654.3_Silent_p.L133L|TCTN1_ENST00000551555.2_3'UTR|HVCN1_ENST00000548312.1_Intron|TCTN1_ENST00000397659.4_Silent_p.L311L			Q2MV58	TECT1_HUMAN	tectonic family member 1	311					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						AGCCGACTCTCGTCAACGCTG	0.507000													28	52					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702859	181702859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181702859C>T	ENST00000526775.1	+	20	3343	c.3178C>T	c.(3178-3180)Ccc>Tcc	p.P1060S	CACNA1E_ENST00000367570.1_Missense_Mutation_p.P1079S|CACNA1E_ENST00000367567.4_Missense_Mutation_p.P686S|CACNA1E_ENST00000360108.3_Missense_Mutation_p.P1060S|CACNA1E_ENST00000357570.5_Missense_Mutation_p.P1030S|CACNA1E_ENST00000358338.5_Missense_Mutation_p.P1011S|CACNA1E_ENST00000367573.2_Missense_Mutation_p.P1079S	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1079					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CGACGTGGACCCCTTGGTGGA	0.627000													10	39					0	0	1	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998360	8998360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8998360G>A	ENST00000310455.3	-	2	952	c.802C>T	c.(802-804)Ctg>Ttg	p.L268L	PPP1R3B_ENST00000519699.1_Silent_p.L268L	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	268					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		TCTGGAAACAGACCATAGGAA	0.532000													16	41					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103907979	103907979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103907979C>T	ENST00000302259.3	+	1	672	c.429C>T	c.(427-429)ccC>ccT	p.P143P	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	143					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGGGCAGCCCCGCCCTGATCC	0.672000													19	42					0	0	1	0	0
GABRG3	2567	broad.mit.edu	37	15	27571983	27571983	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:27571983C>T	ENST00000333743.6	+	4	552	c.298C>T	c.(298-300)Cag>Tag	p.Q100*	GABRG3_ENST00000555083.1_Nonsense_Mutation_p.Q100*	NM_033223.4	NP_150092.2	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	100					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		ATTTTTTGCTCAGACCTGGAC	0.388000													46	92					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287109	202287109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202287109G>A	ENST00000367278.3	+	18	1767	c.1678G>A	c.(1678-1680)Gaa>Aaa	p.E560K	LGR6_ENST00000439764.2_Missense_Mutation_p.E421K|LGR6_ENST00000255432.7_Missense_Mutation_p.E508K	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	560						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						GTACCTCTTTGAAAGCTGGGG	0.612000													35	82					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86386565	86386565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:86386565C>T	ENST00000285379.5	+	4	594	c.364C>T	c.(364-366)Cac>Tac	p.H122Y		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	122					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TCACTTGGTTCACTGGAACAC	0.408000													67	149					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111789272	111789272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:111789272C>T	ENST00000389811.4	+	16	1664	c.1440C>T	c.(1438-1440)tcC>tcT	p.S480S	ACOXL_ENST00000439055.1_Silent_p.S450S			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	480					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						CTTCTCTGTCCCTGGCACACA	0.502000													19	65					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76826243	76826243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76826243C>T	ENST00000248598.5	-	2	705	c.673G>A	c.(673-675)Gag>Aag	p.E225K	CCDC146_ENST00000285871.4_Intron|RP11-467H10.2_ENST00000459742.1_RNA|CCDC146_ENST00000431197.1_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	225	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						CTGTAGGTCTCACTGCTTCTT	0.428000													43	133					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179453325	179453325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179453325C>T	ENST00000589042.1	-	304	63351	c.63127G>A	c.(63127-63129)Gaa>Aaa	p.E21043K	TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E18475K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E19402K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E12170K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E12103K|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E11978K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19402	Fibronectin type-III 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCCAATTTCATTTTCTGCC	0.448000													98	228					0	0	1	0	0
BTBD3	22903	broad.mit.edu	37	20	11903963	11903963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:11903963C>T	ENST00000405977.1	+	5	1843	c.1218C>T	c.(1216-1218)ttC>ttT	p.F406F	BTBD3_ENST00000254977.3_Silent_p.F345F|BTBD3_ENST00000378226.2_Silent_p.F406F|BTBD3_ENST00000399006.2_Silent_p.F345F			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	406										breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						AAAGAGTGTTCATTGCTGGCT	0.522000													23	55					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25701903	25701903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:25701903G>A	ENST00000349320.3	-	10	1430	c.1042C>T	c.(1042-1044)Ctc>Ttc	p.L348F	RHCE_ENST00000455194.1_Missense_Mutation_p.L259F|RHCE_ENST00000425135.1_Missense_Mutation_p.P273L|RHCE_ENST00000374352.2_Missense_Mutation_p.L348F|RHCE_ENST00000413854.1_Intron|RHCE_ENST00000346452.4_Missense_Mutation_p.L213F|RHCE_ENST00000349438.4_Missense_Mutation_p.P319L|RHCE_ENST00000340849.4_Intron|RHCE_ENST00000243186.6_Intron|RHCE_ENST00000294413.7_Missense_Mutation_p.L364F			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	364						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		ATGCTGAGGAGGACCTGGAAG	0.542000													35	163					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678234	100678234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100678234C>T	ENST00000306151.4	+	3	3601	c.3537C>T	c.(3535-3537)acC>acT	p.T1179T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1179	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGGCTAACACCCTTTCAACAA	0.522000													110	479					0	0	1	0	0
ORM2	5005	broad.mit.edu	37	9	117094122	117094122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117094122G>A	ENST00000431067.2	+	5	489	c.453G>A	c.(451-453)acG>acA	p.T151T	ORM2_ENST00000412657.1_3'UTR	NM_000608.2	NP_000599.1			orosomucoid 2											breast(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(1)	7		Myeloproliferative disorder(63;0.163)				AGCCAGAGACGACCAAGGAGC	0.607000													13	32					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240071520	240071520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240071520G>A	ENST00000255380.4	+	5	1548	c.769G>A	c.(769-771)Gaa>Aaa	p.E257K		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	257					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GATCTATAAGGAAACTGAAAA	0.483000													32	88					0	0	1	0	0
FAM159A	348378	broad.mit.edu	37	1	53122628	53122628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53122628G>A	ENST00000517870.1	+	3	639	c.489G>A	c.(487-489)atG>atA	p.M163I	FAM159A_ENST00000401050.3_Intron	NM_001042693.1	NP_001036158.1	Q6UWV7	F159A_HUMAN	family with sequence similarity 159, member A	163						integral to membrane				endometrium(3)|lung(6)|upper_aerodigestive_tract(1)	10						ATTGCTTCATGGCCACAGTGA	0.542000													22	256					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	961030	961030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:961030G>A	ENST00000262301.11	-	4	582	c.564C>T	c.(562-564)tgC>tgT	p.C188C	LMF1_ENST00000399843.2_Silent_p.C188C|LMF1_ENST00000543238.1_Intron|LMF1_ENST00000568897.1_5'UTR|LMF1_ENST00000539379.1_3'UTR	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	188						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				TCCACAGAGGGCACAGGAAGA	0.557000													12	27					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182392099	182392099	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182392099G>A	ENST00000397033.2	+	22	2845	c.2415G>A	c.(2413-2415)atG>atA	p.M805I		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	805					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGGAGAAAATGAACTTAACTT	0.333000													19	62					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33133532	33133532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33133532G>A	ENST00000341947.2	-	63	4771	c.4544C>T	c.(4543-4545)tCg>tTg	p.S1515L	COL11A2_ENST00000374714.1_Missense_Mutation_p.S1489L|COL11A2_ENST00000361917.1_Missense_Mutation_p.S1408L|COL11A2_ENST00000477772.1_5'UTR|COL11A2_ENST00000395197.1_Missense_Mutation_p.S1455L|COL11A2_ENST00000374713.1_Missense_Mutation_p.S1468L|COL11A2_ENST00000374712.1_Missense_Mutation_p.S1434L|COL11A2_ENST00000374708.4_Missense_Mutation_p.S1429L|COL11A2_ENST00000357486.1_Missense_Mutation_p.S1494L	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1515					cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCCATCCACCGAGCGCCGAGT	0.637000													35	83					0	0	1	0	0
KRT6C	286887	broad.mit.edu	37	12	52862934	52862934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52862934C>T	ENST00000252250.6	-	9	1654	c.1607G>A	c.(1606-1608)gGg>gAg	p.G536E		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	536	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GAGGCCACCCCCAATGGCTCT	0.592000													22	69					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31815971	31815971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:31815971G>A	ENST00000446923.2	+	9	3497	c.3106G>A	c.(3106-3108)Gaa>Aaa	p.E1036K	ZEB1_ENST00000560721.2_Missense_Mutation_p.E1032K|ZEB1_ENST00000361642.5_Missense_Mutation_p.E1053K|ZEB1_ENST00000542815.3_Missense_Mutation_p.E985K|ZEB1_ENST00000320985.10_Missense_Mutation_p.E1052K	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1052	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				agaattgcaggaagaaaaaga	0.473000													5	15					0	0	1	0	0
FADS2	9415	broad.mit.edu	37	11	61596039	61596039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61596039C>T	ENST00000278840.4	+	1	807	c.177C>T	c.(175-177)gtC>gtT	p.V59V	FADS2_ENST00000257261.6_Intron|FADS2_ENST00000522056.1_Intron|FADS2_ENST00000521849.1_Silent_p.V59V	NM_004265.2	NP_004256.1	O95864	FADS2_HUMAN	fatty acid desaturase 2	59	Cytochrome b5 heme-binding.				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	GCCAGCGGGTCATCGGGCACT	0.622000											OREG0021015	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	27					0	0	1	0	0
OR52E2	119678	broad.mit.edu	37	11	5080361	5080361	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5080361A>C	ENST00000321522.2	-	1	496	c.497T>G	c.(496-498)tTg>tGg	p.L166W		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGGCAACCGCAATATAAGAAG	0.423000													7	24					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17442179	17442179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17442179G>A	ENST00000159087.4	-	6	786	c.628C>T	c.(628-630)Cct>Tct	p.P210S		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	210						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						TCGTGGACAGGGAACACCTGC	0.637000													17	75					0	0	1	0	0
PRSS12	8492	broad.mit.edu	37	4	119256682	119256682	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119256682C>T	ENST00000296498.3	-	3	1048	c.766G>A	c.(766-768)Ggt>Agt	p.G256S		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	256	SRCR 1.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						CACACCCCACCCTGCCAGATG	0.423000													37	95					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124345682	124345682	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124345682G>A	ENST00000409039.3	+	38	6544	c.6519G>A	c.(6517-6519)agG>agA	p.R2173R		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2173	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACATCTTCAGGGAAATCAACA	0.453000													12	20					0	0	1	0	0
SMYD2	56950	broad.mit.edu	37	1	214504346	214504346	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:214504346C>T	ENST00000366957.5	+	9	892	c.870C>T	c.(868-870)gcC>gcT	p.A290A	SMYD2_ENST00000491455.1_3'UTR|SMYD2_ENST00000415093.2_Intron	NM_020197.2	NP_064582.2	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	290					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding	p.A290A(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		AGGCAGAAGCCATCCGAGACA	0.502000													48	113					0	0	1	0	0
CXCR6	10663	broad.mit.edu	37	3	45988648	45988648	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45988648G>A	ENST00000458629.1	+	1	2138	c.675G>A	c.(673-675)caG>caA	p.Q225Q	CXCR6_ENST00000457814.1_Silent_p.Q225Q|CXCR6_ENST00000438735.1_Silent_p.Q225Q|FYCO1_ENST00000296137.2_Intron|FYCO1_ENST00000535325.1_Intron|FYCO1_ENST00000438446.1_Intron|CXCR6_ENST00000304552.4_Silent_p.Q225Q			O00574	CXCR6_HUMAN	chemokine (C-X-C motif) receptor 6	225					viral genome replication	integral to plasma membrane	coreceptor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|lung(1)|prostate(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GAGGCTTCCAGAAGCACAGAT	0.498000													25	85					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74092231	74092231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74092231G>A	ENST00000443185.2	-	4	2156	c.1839C>T	c.(1837-1839)tcC>tcT	p.S613S	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	613					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TCACCTCTTCGGAAAAGCAGC	0.557000													20	46					0	0	1	0	0
DAND5	199699	broad.mit.edu	37	19	13084208	13084208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13084208C>T	ENST00000317060.2	+	2	509	c.330C>T	c.(328-330)ttC>ttT	p.F110F	DAND5_ENST00000585548.1_3'UTR	NM_152654.2	NP_689867.1	Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	110	CTCK.					extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			CCCAGGTGTTCTCCCGGCCCG	0.622000													19	81					0	0	1	0	0
RBM11	54033	broad.mit.edu	37	21	15599286	15599286	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:15599286C>T	ENST00000400577.3	+	5	527	c.518C>T	c.(517-519)tCa>tTa	p.S173L	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	173							nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GTGTCTTCCTCACTGAATCAT	0.453000													33	269					0	0	1	0	0
HPCAL4	51440	broad.mit.edu	37	1	40149780	40149780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40149780G>A	ENST00000372844.3	-	3	598	c.207C>T	c.(205-207)ttC>ttT	p.F69F		NM_016257.2	NP_057341.1	Q9UM19	HPCL4_HUMAN	hippocalcin like 4	69	EF-hand 2.				central nervous system development	intracellular	calcium ion binding			breast(1)|central_nervous_system(1)|lung(5)|stomach(1)	8	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CGAAGGTGCGGAAAGCGTGCT	0.677000													20	43					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56144898	56144898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:56144898C>T	ENST00000394555.2	-	4	854	c.419G>A	c.(418-420)cGg>cAg	p.R140Q	EFEMP1_ENST00000394554.1_Missense_Mutation_p.R140Q|EFEMP1_ENST00000355426.3_Missense_Mutation_p.R140Q|EFEMP1_ENST00000424836.2_Missense_Mutation_p.R82Q	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	140					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGGGTTCCGCCGGATGACAAA	0.582000													14	99					0	0	1	0	0
TRIM5	85363	broad.mit.edu	37	11	5687273	5687273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5687273G>A	ENST00000305836.5	-	6	1108	c.806C>T	c.(805-807)cCa>cTa	p.P269L	TRIM5_ENST00000380034.3_Missense_Mutation_p.P269L|TRIM5_ENST00000396853.4_Missense_Mutation_p.P270L|TRIM5_ENST00000396855.3_Missense_Mutation_p.P269L|TRIM5_ENST00000380027.1_Missense_Mutation_p.P269L|TRIM5_ENST00000483835.1_5'UTR|TRIM5_ENST00000396847.3_Missense_Mutation_p.P269L			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	269					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		TTGATTTTTTGGAAAAGTTTC	0.403000													30	90					0	0	1	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99338587	99338587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:99338587C>T	ENST00000408927.3	+	9	1090	c.977C>T	c.(976-978)cCa>cTa	p.P326L	RAP1GDS1_ENST00000339360.5_Missense_Mutation_p.P327L|RAP1GDS1_ENST00000380158.4_Missense_Mutation_p.P278L|RAP1GDS1_ENST00000408900.3_Missense_Mutation_p.P277L|RAP1GDS1_ENST00000264572.7_Missense_Mutation_p.P235L|RAP1GDS1_ENST00000453712.2_Missense_Mutation_p.P327L	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	326							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TCTTGGATCCCATCAAATAAC	0.388000			T	NUP98	T-ALL								20	51					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350363	51350363	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51350363C>T	ENST00000327536.5	-	3	693	c.594G>A	c.(592-594)aaG>aaA	p.K198K	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	198										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		GGTTCAGCTTCTTCCGGAACT	0.488000													13	107					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70346365	70346365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70346365C>T	ENST00000305107.6	-	6	1620	c.1574G>A	c.(1573-1575)gGg>gAg	p.G525E	UGT2B4_ENST00000512583.1_3'UTR|UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000381096.3_Missense_Mutation_p.G389E	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	525					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						ATCTCTTTTCCCCTTCTTTCC	0.408000													37	86					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7828164	7828164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7828164C>T	ENST00000327325.5	+	1	130	c.12C>T	c.(10-12)tcC>tcT	p.S4S	CLEC4M_ENST00000334806.5_Silent_p.S4S|CLEC4M_ENST00000359059.5_Silent_p.S4S|CLEC4M_ENST00000597522.1_Silent_p.S4S|CLEC4M_ENST00000596707.1_Silent_p.S4S|CLEC4M_ENST00000248228.4_Silent_p.S4S|CLEC4M_ENST00000596363.1_Silent_p.S4S|CLEC4M_ENST00000394122.2_Silent_p.S4S|CLEC4M_ENST00000595496.1_Silent_p.S4S|CLEC4M_ENST00000357361.2_Silent_p.S4S	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	4					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						TGAGTGACTCCAAGGAACCAA	0.547000													70	47					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430058	43430058	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43430058C>T	ENST00000446844.3	-	0	1199				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GCTGAAACTTCCCATTAATTG	0.458000													94	298					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389456	4389456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4389456C>T	ENST00000408920.2	-	1	160	c.70G>A	c.(70-72)Gac>Aac	p.D24N		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGTGCTGGTCCTGTAGGCCA	0.517000													19	22					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2711054	2711054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2711054C>T	ENST00000399655.1	+	22	3153	c.2888C>T	c.(2887-2889)tCt>tTt	p.S963F	CACNA1C_ENST00000347598.4_Missense_Mutation_p.S983F|CACNA1C_ENST00000399591.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000480911.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000344100.3_Missense_Mutation_p.S963F|CACNA1C_ENST00000399597.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000335762.5_Missense_Mutation_p.S988F|CACNA1C_ENST00000399595.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399603.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399617.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399606.1_Missense_Mutation_p.S983F|CACNA1C_ENST00000399621.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399601.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399638.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399649.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399644.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399629.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000327702.7_Missense_Mutation_p.S963F|CACNA1C_ENST00000399634.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399637.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000406454.3_Missense_Mutation_p.S963F|CACNA1C_ENST00000402845.3_Missense_Mutation_p.S963F|CACNA1C_ENST00000399641.1_Missense_Mutation_p.S963F	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	983					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity	p.S498Y(1)|p.S963Y(1)|p.S1013Y(1)		NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CACAAGGGTTCTTTCTGCCGG	0.577000													17	42					0	0	1	0	0
IGLV3-27	28791	broad.mit.edu	37	22	23011177	23011177	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23011177C>T	ENST00000390304.2	+	0	278																											CTGAGCGATTCTCCGGCTCCA	0.557000													17	37					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	7995115	7995115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:7995115C>T	ENST00000377507.3	-	6	668	c.502G>A	c.(502-504)Gga>Aga	p.G168R		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	168					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGATGCTCCCGGAGAGAGG	0.542000													13	65					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5282896	5282896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5282896G>A	ENST00000546004.1	-	3	1191	c.945C>T	c.(943-945)ttC>ttT	p.F315F	PROKR2_ENST00000217270.3_Silent_p.F315F			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	315						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CGACCACGTAGAAGGCAGTGA	0.517000										HNSCC(71;0.22)			15	132					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729720	62729720	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62729720C>T	ENST00000349451.3	+	6	1093	c.681C>T	c.(679-681)ccC>ccT	p.P227P	OPRL1_ENST00000336866.2_Silent_p.P227P|OPRL1_ENST00000355631.4_Silent_p.P227P	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	227					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TCATCGTCCCCGTGCTCGTCA	0.622000													58	116					0	0	1	0	0
TESC	54997	broad.mit.edu	37	12	117479781	117479781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117479781C>T	ENST00000335209.7	-	7	724	c.538G>A	c.(538-540)Gag>Aag	p.E180K	TESC_ENST00000392545.4_Missense_Mutation_p.E233K|TESC_ENST00000541210.1_Missense_Mutation_p.E153K			Q96BS2	TESC_HUMAN	tescalcin	180					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		GTGATCCCCTCGTACACCTGA	0.667000													4	8					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808333	48808333	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48808333G>A	ENST00000309835.3	+	1	571	c.561G>A	c.(559-561)tgG>tgA	p.W187*	STON1_ENST00000406226.1_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000405008.1_Nonsense_Mutation_p.W187*|STON1_ENST00000404752.1_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000402114.2_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000394751.3_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000394754.1_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000309827.2_Nonsense_Mutation_p.W187*					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTCCATTTTGGAAAGATGAAG	0.428000													7	87					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907015	77907015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77907015C>T	ENST00000355300.6	-	2	1408	c.1234G>A	c.(1234-1236)Gat>Aat	p.D412N	LINGO1_ENST00000561030.1_Missense_Mutation_p.D406N	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	412	Ig-like C2-type.|LRRCT.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						AGTAGCACATCAGGGAAGTCC	0.652000													4	32					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31154973	31154973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31154973G>A	ENST00000349752.5	-	10	1658	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	GALNT14_ENST00000406653.1_Missense_Mutation_p.P320L|GALNT14_ENST00000356174.3_Missense_Mutation_p.P307L|GALNT14_ENST00000324589.5_Missense_Mutation_p.P345L|GALNT14_ENST00000420311.2_Missense_Mutation_p.P305L|GALNT14_ENST00000486564.1_5'UTR	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	340						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					GAAAACGTAGGGGTGCTTCTT	0.602000													31	71					0	0	1	0	0
AMIGO1	57463	broad.mit.edu	37	1	110051073	110051073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110051073G>A	ENST00000369864.4	-	2	811	c.462C>T	c.(460-462)ttC>ttT	p.F154F	AMIGO1_ENST00000369862.1_Silent_p.F154F			Q86WK6	AMGO1_HUMAN	adhesion molecule with Ig-like domain 1	154					axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		CCATGTCATCGAAGGCGCACC	0.537000													36	109					0	0	1	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215667	20215667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20215667C>T	ENST00000331723.1	+	1	81	c.81C>T	c.(79-81)ctC>ctT	p.L27L		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCTATTTCTCTTCTTACTAT	0.393000													54	114					0	0	1	0	0
SYNJ2BP	55333	broad.mit.edu	37	14	70842434	70842434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70842434G>A	ENST00000256366.4	-	3	337	c.256C>T	c.(256-258)Cgt>Tgt	p.R86C	RP11-718G2.3_ENST00000555276.1_RNA|SYNJ2BP_ENST00000554216.1_5'UTR	NM_018373.2	NP_060843.2			synaptojanin 2 binding protein											central_nervous_system(1)|kidney(2)|large_intestine(1)|upper_aerodigestive_tract(1)	5				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		CCTGCATTACGAAAGAGGTCT	0.463000													52	133					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2820136	2820136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2820136G>A	ENST00000520002.1	-	62	10038	c.9483C>T	c.(9481-9483)atC>atT	p.I3161I	CSMD1_ENST00000542608.1_Silent_p.I2983I|CSMD1_ENST00000400186.3_Silent_p.I2984I|CSMD1_ENST00000602557.1_Silent_p.I3161I|CSMD1_ENST00000537824.1_Silent_p.I3160I|CSMD1_ENST00000602723.1_Silent_p.I2984I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3161	Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTTCTGCGGGGATGCCAGGGT	0.493000													12	11					0	0	1	0	0
SNCB	6620	broad.mit.edu	37	5	176056599	176056599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176056599C>T	ENST00000310112.3	-	3	307	c.57G>A	c.(55-57)gcG>gcA	p.A19A	SNCB_ENST00000393693.2_Silent_p.A19A|SNCB_ENST00000506696.1_Silent_p.A19A|SNCB_ENST00000510387.1_Silent_p.A19A	NM_001001502.1	NP_001001502.1	Q16143	SYUB_HUMAN	synuclein, beta	19							calcium ion binding|phospholipase inhibitor activity			breast(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	10	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGTTTTCTCCGCGGCTGCCA	0.672000													11	29					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	36943516	36943516	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:36943516G>A	ENST00000379242.3	+	2	305	c.3G>A	c.(1-3)atG>atA	p.M1I	VIT_ENST00000457137.2_Start_Codon_SNP_p.M1I|VIT_ENST00000401530.1_Start_Codon_SNP_p.M1I|VIT_ENST00000379241.3_Start_Codon_SNP_p.M1I|VIT_ENST00000404084.1_Start_Codon_SNP_p.M1I|VIT_ENST00000389975.3_Start_Codon_SNP_p.M1I|VIT_ENST00000497382.1_5'UTR	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	1						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				TGATATTTATGAGGACTGTTG	0.383000													20	65					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121498457	121498457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121498457C>T	ENST00000260197.7	+	47	6687	c.6558C>T	c.(6556-6558)ttC>ttT	p.F2186F	SORL1_ENST00000527934.1_Silent_p.F801F|SORL1_ENST00000525532.1_Silent_p.F1130F|SORL1_ENST00000532694.1_Silent_p.F1032F|SORL1_ENST00000534286.1_Silent_p.F1096F	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2186					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CCGCAATCTTCTCCTCTGGGG	0.607000													7	38					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99367785	99367785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99367785G>A	ENST00000336411.2	-	5	575	c.392C>T	c.(391-393)tCa>tTa	p.S131L	CYP3A4_ENST00000354593.2_Intron	NM_001202855.2|NM_017460.5	NP_001189784.1|NP_059488.2	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	131					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	AGACAGCAATGATCGTAATCT	0.388000													37	101					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121393311	121393311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121393311C>T	ENST00000260197.7	+	10	1550	c.1421C>T	c.(1420-1422)tCc>tTc	p.S474F	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	474					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CAGGGCTGTTCCCTTCATCTG	0.572000													52	172					0	0	1	0	0
DKK1	22943	broad.mit.edu	37	10	54074332	54074332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:54074332C>T	ENST00000373970.3	+	1	277	c.138C>T	c.(136-138)ccC>ccT	p.P46P		NM_012242.2	NP_036374.1	O94907	DKK1_HUMAN	dickkopf WNT signaling pathway inhibitor 1	46					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			kidney(2)|large_intestine(4)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	16						AGAACCTGCCCCCACCGCTGG	0.647000											OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	95					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68956332	68956332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68956332G>A	ENST00000356291.2	-	3	250	c.191C>T	c.(190-192)tCt>tTt	p.S64F		NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	64	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						GACTTTAAAAGAGGCAAGGTA	0.328000													6	117					0	0	1	0	0
ZNF503	84858	broad.mit.edu	37	10	77159218	77159218	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:77159218G>A	ENST00000372524.4	-	2	1716	c.1230C>T	c.(1228-1230)tcC>tcT	p.S410S	RP11-399K21.11_ENST00000418818.2_lincRNA|ZNF503_ENST00000535216.1_Silent_p.S410S	NM_032772.4	NP_116161.2	Q96F45	ZN503_HUMAN	zinc finger protein 503	410	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			lung(4)|ovary(1)|skin(1)	6	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					CCAAAGGGCTGGAGCCGGCCG	0.716000													4	4					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38237701	38237701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38237701G>A	ENST00000379705.3	-	6	2397	c.1540C>T	c.(1540-1542)Ctg>Ttg	p.L514L	TRPC4_ENST00000338947.5_Silent_p.L341L|TRPC4_ENST00000358477.2_Silent_p.L514L|TRPC4_ENST00000379681.3_Silent_p.L514L|TRPC4_ENST00000447043.1_Silent_p.L514L|TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000379673.2_Silent_p.L514L|TRPC4_ENST00000494529.1_5'UTR|TRPC4_ENST00000379679.1_Silent_p.L341L|TRPC4_ENST00000355779.2_Silent_p.L514L			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	514					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AAAATGTCCAGGAGCATTCTT	0.388000													23	63					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72889564	72889564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:72889564G>A	ENST00000264839.7	+	5	758	c.758G>A	c.(757-759)gGg>gAg	p.G253E	RIMS1_ENST00000348717.5_Missense_Mutation_p.G253E|RIMS1_ENST00000520567.1_Missense_Mutation_p.G253E|RIMS1_ENST00000517960.1_Missense_Mutation_p.G253E|RIMS1_ENST00000521978.1_Missense_Mutation_p.G253E|RIMS1_ENST00000522291.1_Missense_Mutation_p.G253E|RIMS1_ENST00000518273.1_Missense_Mutation_p.G253E|RIMS1_ENST00000491071.2_Missense_Mutation_p.G253E			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	253					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAAGCCTTGGGGCCTGAACAG	0.557000													10	18					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94069757	94069757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94069757C>T	ENST00000553484.1	+	26	3901	c.3747C>T	c.(3745-3747)tcC>tcT	p.S1249S	UNC79_ENST00000555664.1_Silent_p.S1249S|UNC79_ENST00000256339.4_Silent_p.S1072S|UNC79_ENST00000393151.2_Silent_p.S1249S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1249						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCCTGACCTCCAAAATTCGTT	0.478000													10	45					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102964006	102964006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102964006C>T	ENST00000359520.7	+	19	4257	c.4031C>T	c.(4030-4032)cCc>cTc	p.P1344L		NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1344							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						GACAAGAACCCCGCCGGGGAC	0.672000													6	19					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205549071	205549071	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205549071C>T	ENST00000367147.4	+	2	516	c.423C>T	c.(421-423)ttC>ttT	p.F141F	MFSD4_ENST00000539267.1_Silent_p.F141F|MFSD4_ENST00000536357.1_Silent_p.F141F	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	141					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CGGCCGTCTTCCTCCAGGTAA	0.672000													12	35					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23851691	23851691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23851691G>A	ENST00000405093.3	-	38	5812	c.5742C>T	c.(5740-5742)atC>atT	p.I1914I	MYH6_ENST00000356287.3_Silent_p.I1914I	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1914					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle	p.I1914I(1)		breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GGGACTCAGCGATGTCCGCCC	0.592000													42	96					0	0	1	0	0
MAPK15	225689	broad.mit.edu	37	8	144800391	144800391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144800391G>A	ENST00000338033.4	+	4	324	c.205G>A	c.(205-207)Gac>Aac	p.D69N	MAPK15_ENST00000395107.4_Missense_Mutation_p.D69N|MAPK15_ENST00000395108.2_Missense_Mutation_p.D69N	NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	69	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGAGTTTGGGGACCATCCCAA	0.592000													20	47					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14160099	14160099	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14160099G>A	ENST00000263379.2	+	10	1500	c.1375G>A	c.(1375-1377)Gga>Aga	p.G459R		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	459	Fibronectin type-III 3.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						TGCACAGAGTGGAACCAGCCC	0.642000													7	81					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183191281	183191281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183191281C>T	ENST00000264144.4	+	6	763	c.698C>T	c.(697-699)tCa>tTa	p.S233L	LAMC2_ENST00000493293.1_Missense_Mutation_p.S233L	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	233	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						CTCCAATGGTCACAGCGCCAT	0.488000													34	115					0	0	1	0	0
URM1	81605	broad.mit.edu	37	9	131151740	131151740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131151740C>T	ENST00000452446.1	+	4	451	c.389C>T	c.(388-390)cCa>cTa	p.P130L	URM1_ENST00000483206.1_3'UTR|URM1_ENST00000372850.1_3'UTR|URM1_ENST00000372853.4_Intron	NM_001135947.2	NP_001129419.1	Q9BTM9	URM1_HUMAN	ubiquitin related modifier 1	0					tRNA thio-modification|tRNA wobble uridine modification		protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)	5						TCTCCCACTCCAGGTGAGGAA	0.562000													7	5					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003933	122003933	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122003933G>A	ENST00000498619.1	+	7	3600	c.3162G>A	c.(3160-3162)gtG>gtA	p.V1054V	CASR_ENST00000296154.5_Silent_p.V1044V|CASR_ENST00000490131.1_Silent_p.V1044V	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	1044					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GGCCAGAGGTGGAGGACCCTG	0.547000													27	92					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7571715	7571715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7571715G>A	ENST00000379802.3	+	14	2142	c.1801G>A	c.(1801-1803)Gga>Aga	p.G601R	DSP_ENST00000418664.2_Missense_Mutation_p.G601R	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	601	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGAGATGTTTGGAGATGATGA	0.483000													28	216					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75406808	75406808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75406808G>A	ENST00000394810.2	-	4	2751	c.2602C>T	c.(2602-2604)Ccc>Tcc	p.P868S	SYNPO2L_ENST00000372873.4_Missense_Mutation_p.P644S|SYNPO2L_ENST00000372872.4_Intron	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	868	Pro-rich.					cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					GGAGTCGGGGGAACCTCATCA	0.582000													50	134					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27857437	27857437	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:27857437C>T	ENST00000261716.3	+	18	2680	c.2161C>T	c.(2161-2163)Caa>Taa	p.Q721*	TAOK1_ENST00000536202.1_Nonsense_Mutation_p.Q573*	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	721					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			TAAAGAACTCCAAATAAAAAA	0.353000													12	13					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183211937	183211937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183211937C>T	ENST00000341319.3	-	5	1315	c.1280G>A	c.(1279-1281)gGa>gAa	p.G427E		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	427										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTCAAAGCCTCCGATCACATA	0.458000													41	139					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55183954	55183954	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:55183954C>T	ENST00000337714.3	+	2	1362	c.1129C>T	c.(1129-1131)Cag>Tag	p.Q377*	AKAP1_ENST00000571629.1_Nonsense_Mutation_p.Q377*|AKAP1_ENST00000572557.1_Nonsense_Mutation_p.Q377*|AKAP1_ENST00000314126.3_Nonsense_Mutation_p.Q377*|AKAP1_ENST00000539273.1_Nonsense_Mutation_p.Q377*	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	377					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					TCGTGTGTGTCAGGCCAGTCA	0.577000													16	94					0	0	1	0	0
CASQ2	845	broad.mit.edu	37	1	116311118	116311118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:116311118G>A	ENST00000261448.5	-	1	284	c.45C>T	c.(43-45)tcC>tcT	p.S15S	CASQ2_ENST00000456138.2_Silent_p.S15S	NM_001232.3	NP_001223.2	O14958	CASQ2_HUMAN	calsequestrin 2 (cardiac muscle)	15					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	18	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CCCTGCAAGAGGACAGAAAAT	0.418000													18	37					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160274736	160274736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:160274736C>T	ENST00000264431.4	+	22	4125	c.3706C>T	c.(3706-3708)Cgc>Tgc	p.R1236C		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1236					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TCAGGGGGATCGCGCGTCACT	0.532000													29	107					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51294740	51294740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51294740C>T	ENST00000261842.5	+	21	3401	c.3295C>T	c.(3295-3297)Ccc>Tcc	p.P1099S	AP4E1_ENST00000560508.1_Missense_Mutation_p.P1024S|AP4E1_ENST00000561397.1_3'UTR	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	1099					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		CCCATCCATCCCCTGCTTACT	0.413000													59	155					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133175158	133175158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133175158G>A	ENST00000329321.3	+	1	1012	c.543G>A	c.(541-543)gtG>gtA	p.V181V		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	181						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding	p.V181V(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ACCCCCTGGTGAACGTGCCCA	0.617000													19	62					0	0	1	0	0
DPPA3P2	400206	broad.mit.edu	37	14	36840769	36840769	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:36840769G>A	ENST00000557188.1	+	0	400																											CGCTAGTAGCGAATCTGTTTC	0.502000													14	26					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4525644	4525644	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4525644C>T	ENST00000381848.3	-	6	801		c.e6+1			NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5							lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CGGGCTCTCACCAGCTCCAGC	0.637000													12	50					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43250649	43250649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43250649C>T	ENST00000259750.4	+	14	2254	c.2171C>T	c.(2170-2172)cCt>cTt	p.P724L		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	724						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCACTGGCTCCTGTTCAGCCT	0.587000													28	40					0	0	1	0	0
TRIM6	117854	broad.mit.edu	37	11	5626743	5626743	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5626743G>A	ENST00000380097.3	+	4	1022	c.780G>A	c.(778-780)gaG>gaA	p.E260E	TRIM6_ENST00000445329.1_Silent_p.E57E|AC015691.13_ENST00000394793.2_RNA|TRIM6_ENST00000507320.1_Silent_p.E57E|TRIM6_ENST00000506134.1_Silent_p.E57E|TRIM6-TRIM34_ENST00000354852.5_Silent_p.E260E|TRIM6_ENST00000515022.1_Silent_p.E57E|TRIM6_ENST00000380107.1_Silent_p.E206E|TRIM6_ENST00000278302.5_Silent_p.E232E|HBG2_ENST00000380259.2_Intron	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		CGCTGCGAGAGCTCATCTCGG	0.522000											OREG0003723	type=REGULATORY REGION|Gene=TRIM6|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	13	48					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984756	85984756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85984756G>A	ENST00000372113.4	-	2	230	c.225C>T	c.(223-225)ttC>ttT	p.F75F	LRIT2_ENST00000538192.1_Silent_p.F75F	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	75						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						TCATGTTGATGAAAGACCCTT	0.463000													13	114					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27949610	27949610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27949610C>T	ENST00000374005.3	-	4	560	c.272G>A	c.(271-273)cGa>cAa	p.R91Q	FGR_ENST00000399173.1_Missense_Mutation_p.R91Q|FGR_ENST00000374004.1_Missense_Mutation_p.R91Q|FGR_ENST00000545953.1_Missense_Mutation_p.R91Q	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	91	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ATCCTCAGTTCGAGCCTCATA	0.562000													12	36					0	0	1	0	0
ANKK1	255239	broad.mit.edu	37	11	113270348	113270348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113270348C>T	ENST00000303941.3	+	8	1751	c.1657C>T	c.(1657-1659)Cct>Tct	p.P553S		NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	553							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|stomach(1)	29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		TGGAGCGGTCCCTGATGCCCT	0.597000													6	8					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38802870	38802870	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38802870C>T	ENST00000449082.2	-	6	695	c.696G>A	c.(694-696)ctG>ctA	p.L232L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	232					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAATGACCTTCAGGCCTGCGG	0.512000													11	37					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113547238	113547238	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113547238C>T	ENST00000416899.2	+	10	1630	c.1504C>T	c.(1504-1506)Ctt>Ttt	p.L502F	MUSK_ENST00000374448.4_Missense_Mutation_p.L510F|MUSK_ENST00000189978.5_Missense_Mutation_p.L510F|MUSK_ENST00000374438.1_Intron			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	510					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						ATTTGTGCTTCTTACCATAAC	0.373000													40	123					0	0	1	0	0
ACTA1	58	broad.mit.edu	37	1	229568311	229568311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:229568311C>T	ENST00000366684.3	-	3	548	c.446G>A	c.(445-447)aGg>aAg	p.R149K	ACTA1_ENST00000366683.2_Intron	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	149					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	ACCGGTGGTCCTGCCGGAGGC	0.711000													20	48					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96264406	96264406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:96264406C>T	ENST00000347108.3	-	9	1631	c.1199G>A	c.(1198-1200)cGa>cAa	p.R400Q	DZIP1_ENST00000361396.2_Missense_Mutation_p.R400Q|DZIP1_ENST00000376829.2_Missense_Mutation_p.R400Q|DZIP1_ENST00000361156.3_Missense_Mutation_p.R400Q			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	400					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			cattgAGGTTCGAAGTTTCTC	0.378000													25	71					0	0	1	0	0
SSTR2	6752	broad.mit.edu	37	17	71166148	71166148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:71166148C>T	ENST00000357585.2	+	2	1059	c.690C>T	c.(688-690)ttC>ttT	p.F230F	RP11-143K11.5_ENST00000580671.1_RNA|SSTR2_ENST00000315332.2_Silent_p.F230F	NM_001050.2	NP_001041.1	P30874	SSR2_HUMAN	somatostatin receptor 2	230					digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity			endometrium(2)|large_intestine(5)|lung(2)|prostate(2)	11			LUSC - Lung squamous cell carcinoma(166;0.197)			GCTACCTGTTCATTATCATCA	0.512000													38	139					0	0	1	0	0
MRPL49	740	broad.mit.edu	37	11	64893018	64893018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64893018C>T	ENST00000534078.1	+	2	173	c.137C>T	c.(136-138)tCt>tTt	p.S46F	MRPL49_ENST00000279242.2_Silent_p.V96V|MRPL49_ENST00000526171.1_Silent_p.V96V|MRPL49_ENST00000531705.1_Intron|MRPL49_ENST00000524482.1_3'UTR			Q13405	RM49_HUMAN	mitochondrial ribosomal protein L49	0					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			endometrium(1)|ovary(1)	2						ACATCCCCGTCTACAAGGACA	0.552000													23	82					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943464	72943464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72943464G>A	ENST00000328801.4	+	6	1514	c.1514G>A	c.(1513-1515)gGc>gAc	p.G505D		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	505						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CTGGGCCAGGGCCTGCAGCGG	0.642000													17	42					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5238990	5238990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5238990G>A	ENST00000372412.4	-	13	2025	c.1792C>T	c.(1792-1794)Cgc>Tgc	p.R598C	PTPRS_ENST00000588012.1_Missense_Mutation_p.R584C|PTPRS_ENST00000357368.4_Missense_Mutation_p.R597C|PTPRS_ENST00000353284.2_Missense_Mutation_p.R584C|PTPRS_ENST00000348075.2_Missense_Mutation_p.R584C|PTPRS_ENST00000592099.1_Missense_Mutation_p.R584C|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000587303.1_Missense_Mutation_p.R597C|PTPRS_ENST00000262963.6_Missense_Mutation_p.R593C			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	597	Fibronectin type-III 3.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TGCGGCGAGCGGGCCGCCAGG	0.711000													19	61					0	0	1	0	0
TRBV24-1	28563	broad.mit.edu	37	7	142364233	142364233	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142364233C>T	ENST00000390397.2	+	0	36																											CTCTTCATGCCATGGCCTCCC	0.493000													5	20					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93170762	93170762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93170762G>A	ENST00000298050.3	+	14	1792	c.1692G>A	c.(1690-1692)ctG>ctA	p.L564L	CCDC67_ENST00000525646.1_Silent_p.L306L	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	564										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				ATTTCCTTCTGGAAGAAGAGA	0.378000													20	42					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113694393	113694393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113694393C>T	ENST00000003302.4	-	12	1285	c.1217G>A	c.(1216-1218)cGa>cAa	p.R406Q	USP28_ENST00000537706.1_Missense_Mutation_p.R406Q|USP28_ENST00000545540.1_Missense_Mutation_p.R281Q|USP28_ENST00000544967.1_Missense_Mutation_p.R114Q|USP28_ENST00000260188.5_Missense_Mutation_p.R406Q	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	406					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCTCTTATTTCGAATAAGCTC	0.318000													17	67					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54802110	54802110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54802110C>T	ENST00000391745.1	-	10	1445	c.1129G>A	c.(1129-1131)Gag>Aag	p.E377K	LILRA3_ENST00000391744.3_Missense_Mutation_p.E296K|LILRA3_ENST00000251390.3_Missense_Mutation_p.E360K					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCTGCCCCCTCCTTGGTCAAA	0.597000													41	124					0	0	1	0	0
IGHV3-43	28426	broad.mit.edu	37	14	106926359	106926359	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106926359C>T	ENST00000434710.1	-	0	262																											CCAGACCCTTCCCCGGAGCTT	0.542000													72	153					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26273425	26273425	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:26273425G>A	ENST00000381655.2	+	25	2468	c.2326G>A	c.(2326-2328)Gaa>Aaa	p.E776K	ATP8A2_ENST00000491840.1_3'UTR|ATP8A2_ENST00000255283.8_Missense_Mutation_p.E736K	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	736					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GCTCTCCTTCGAAGTCCGGAG	0.542000													8	46					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122811931	122811931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122811931G>A	ENST00000194130.2	-	3	295	c.256C>T	c.(256-258)Cac>Tac	p.H86Y	SLC13A1_ENST00000539873.1_Missense_Mutation_p.H22Y	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	86						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	AGCAGTAAGTGAAAATCCTTG	0.338000													26	79					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841810	13841810	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13841810G>A	ENST00000265104.4	-	33	5579	c.5475C>T	c.(5473-5475)ttC>ttT	p.F1825F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1825	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCTGAGCAGGGAAGGATGAAA	0.358000									Kartagener syndrome				29	57					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73100164	73100164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73100164C>T	ENST00000450736.2	+	5	1668	c.1253C>T	c.(1252-1254)gCc>gTc	p.A418V	SLC16A5_ENST00000580123.1_Missense_Mutation_p.A418V|SLC16A5_ENST00000329783.4_Missense_Mutation_p.A418V|SLC16A5_ENST00000538213.2_Missense_Mutation_p.A458V			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	418					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	AGCTTCTACGCCCTGCAGAAG	0.567000													18	108					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292806	4292806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4292806C>T	ENST00000301272.2	-	5	684	c.639G>A	c.(637-639)ggG>ggA	p.G213G	TMIGD2_ENST00000600349.1_Silent_p.G41G|TMIGD2_ENST00000600114.1_Silent_p.G93G|TMIGD2_ENST00000595645.1_Silent_p.G209G	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	213						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGGTCCTTCCCCTCTCCAG	0.622000													8	105					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54849620	54849620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:54849620C>T	ENST00000333896.5	+	8	1406	c.1021C>T	c.(1021-1023)Ccc>Tcc	p.P341S	SPTBN1_ENST00000356805.4_Missense_Mutation_p.P354S	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	354					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GGAGAAACCACCCAAGTAAGA	0.413000													8	110					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915457	46915457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46915457C>T	ENST00000307522.3	-	1	1384	c.611G>A	c.(610-612)gGg>gAg	p.G204E		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	204						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTTCAGCTTCCCCCAGGACAC	0.692000													14	20					0	0	1	0	0
HTR7P1	93164	broad.mit.edu	37	12	13155411	13155411	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13155411C>T	ENST00000543321.1	+	0	31				HTR7P1_ENST00000535469.1_RNA																							GCAGCGACTACCTTGGGGATC	0.527000													6	17					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64815823	64815823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64815823C>T	ENST00000358658.3	-	9	1260	c.1233G>A	c.(1231-1233)gcG>gcA	p.A411A	NAALADL1_ENST00000339885.2_Silent_p.A411A|NAALADL1_ENST00000355721.3_Silent_p.A370A|NAALADL1_ENST00000356632.3_Silent_p.A376A|NAALADL1_ENST00000355369.2_Silent_p.A411A|NAALADL1_ENST00000526799.1_5'UTR|NAALADL1_ENST00000340252.4_Silent_p.A462A|NAALADL1_ENST00000528884.1_5'UTR	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	411	NAALADase.				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CCCCCCAGCTCGCAAACACGA	0.582000													9	99					0	0	1	0	0
XCR1	2829	broad.mit.edu	37	3	46062465	46062465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46062465G>A	ENST00000309285.3	-	2	1331	c.975C>T	c.(973-975)ttC>ttT	p.F325F	XCR1_ENST00000542109.1_Silent_p.F325F	NM_001024644.1	NP_001019815.1	P46094	XCR1_HUMAN	chemokine (C motif) receptor 1	325					chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CCTCATAGGCGAAGGCACCAG	0.647000													5	10					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75156789	75156789	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:75156789G>A	ENST00000342232.4	-	4	1920	c.1880C>T	c.(1879-1881)cCt>cTt	p.P627L	JPH1_ENST00000518195.1_5'UTR	NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	627					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			TTCCAAAGCAGGGCATGAATC	0.433000													30	169					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240256102	240256102	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240256102G>A	ENST00000319653.9	+	1	923	c.693G>A	c.(691-693)gaG>gaA	p.E231E		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	231					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCGCCGAGGAGCCTGCAGCGC	0.736000													5	14					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216784	21216784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21216784G>A	ENST00000380216.1	-	1	526	c.521C>T	c.(520-522)tCc>tTc	p.S174F		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	174					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AAAAGAGAAGGATCTCATGAT	0.383000													144	244					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129096476	129096476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129096476C>T	ENST00000249344.2	+	9	1071	c.1031C>T	c.(1030-1032)tCt>tTt	p.S344F	STRIP2_ENST00000435494.2_Missense_Mutation_p.S344F	NM_020704.2	NP_065755.1			striatin interacting protein 2																		CGCCGTGGCTCTCGAAGGGTA	0.552000													14	27					0	0	1	0	0
UBE2D3	7323	broad.mit.edu	37	4	103730987	103730987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:103730987G>A	ENST00000453744.2	-	3	563	c.50C>T	c.(49-51)cCt>cTt	p.P17L	UBE2D3_ENST00000349311.8_Missense_Mutation_p.P17L|UBE2D3_ENST00000343106.5_Missense_Mutation_p.P17L|UBE2D3_ENST00000502404.1_5'UTR|UBE2D3_ENST00000507845.1_5'UTR|UBE2D3_ENST00000338145.3_Missense_Mutation_p.P17L|UBE2D3_ENST00000394801.4_Missense_Mutation_p.P17L|UBE2D3_ENST00000321805.7_Missense_Mutation_p.P17L|UBE2D3_ENST00000394804.2_Missense_Mutation_p.P17L|UBE2D3_ENST00000504211.1_5'UTR|UBE2D3_ENST00000394803.5_Missense_Mutation_p.P17L|UBE2D3_ENST00000513098.1_5'UTR|UBE2D3_ENST00000350435.7_Missense_Mutation_p.P11L|UBE2D3_ENST00000505207.1_5'UTR|UBE2D3_ENST00000357194.6_Missense_Mutation_p.P19L	NM_181891.1	NP_871620.1	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3	17					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		TTGTGCTGGAGGGTCACGGGC	0.383000													47	109					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20490535	20490535	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20490535G>A	ENST00000555186.1	+	0	515					NR_038836.1																						TGTTGGTAGTGGATCCAAAGG	0.428000													37	264					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129122724	129122724	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129122724C>T	ENST00000249344.2	+	20	2131	c.2091C>T	c.(2089-2091)gcC>gcT	p.A697A	STRIP2_ENST00000435494.2_Silent_p.A697A	NM_020704.2	NP_065755.1			striatin interacting protein 2																		TAAAGCGGGCCCTCAAGGTCA	0.443000													34	90					0	0	1	0	0
AHCYL2	23382	broad.mit.edu	37	7	128865045	128865045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128865045C>T	ENST00000325006.3	+	1	182	c.128C>T	c.(127-129)cCc>cTc	p.P43L	AHCYL2_ENST00000446544.2_Missense_Mutation_p.P43L	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	43					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						GCCATGGCCCCCCCGGCGGGC	0.786000													3	1					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987664	61987664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61987664G>A	ENST00000450719.3	-	3	284	c.47C>T	c.(46-48)tCc>tTc	p.S16F	CSHL1_ENST00000438387.2_Missense_Mutation_p.S27F|CSHL1_ENST00000346606.6_Missense_Mutation_p.S16F|CSHL1_ENST00000309894.5_Missense_Mutation_p.S110F|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000561003.1_Missense_Mutation_p.S27F|CSHL1_ENST00000259003.10_Missense_Mutation_p.S48F|CSHL1_ENST00000558099.1_5'UTR			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	110						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						GAGCAGCAGGGAGATGTGGAG	0.627000													17	38					0	0	1	0	0
GET4	51608	broad.mit.edu	37	7	927046	927046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:927046C>T	ENST00000407192.1	+	3	2714	c.197C>T	c.(196-198)tCt>tTt	p.S66F	GET4_ENST00000265857.3_Missense_Mutation_p.S119F			Q7L5D6	GET4_HUMAN	golgi to ER traffic protein 4 homolog (S. cerevisiae)	119					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding			breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GACCCCAACTCTCCTGAGCGC	0.622000													37	95					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59166625	59166625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:59166625C>T	ENST00000262717.4	+	3	851	c.453C>T	c.(451-453)ttC>ttT	p.F151F	CDH20_ENST00000536675.2_Silent_p.F151F|CDH20_ENST00000538374.1_Silent_p.F151F			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	151	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				AGTCAGAGTTCATCATCAAAA	0.537000													9	33					0	0	1	0	0
OR13C9	286362	broad.mit.edu	37	9	107380208	107380208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107380208G>A	ENST00000259362.1	-	1	277	c.278C>T	c.(277-279)tCc>tTc	p.S93F		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						GCCAGAAAAGGAAATGGTCTT	0.502000													32	120					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90398133	90398133	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90398133C>T	ENST00000405460.2	+	87	18504	c.18408C>T	c.(18406-18408)ctC>ctT	p.L6136L	GPR98_ENST00000425867.2_Silent_p.L1797L	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6136					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGTTGGTTCTCTTTGTCATTT	0.373000											OREG0016703	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	14					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697782	6697782	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6697782C>T	ENST00000245907.6	-	20	2556	c.2464G>A	c.(2464-2466)Gag>Aag	p.E822K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	822					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACTGTGACCTCGAAGGGGTCT	0.562000													5	40					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940498	144940498	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144940498G>A	ENST00000525985.1	-	2	6995	c.6924C>T	c.(6922-6924)acC>acT	p.T2308T				P58107	EPIPL_HUMAN	epiplakin 1	2308						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGTGTAGCCGGTGACGGCGC	0.706000													14	260					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60912783	60912783	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60912783G>A	ENST00000252999.3	-	16	2093	c.2026_splice	c.e16-1	p.P676_splice		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	676	Laminin EGF-like 7.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCAGTGGCAGGCTGCAGACAA	0.662000													12	38					0	0	1	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46106066	46106066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46106066G>A	ENST00000355105.3	-	8	1920	c.560C>T	c.(559-561)cCt>cTt	p.P187L	GPBP1L1_ENST00000290795.3_Missense_Mutation_p.P187L	NM_021639.4	NP_067652.1	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding		GPBP1L1/MAST2_ENST00000361297(2)	breast(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|stomach(1)	21	Acute lymphoblastic leukemia(166;0.155)					CTTGGCACTAGGCGGGTTTTC	0.443000													59	144					0	0	1	0	0
SMTN	6525	broad.mit.edu	37	22	31487759	31487759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31487759C>T	ENST00000333137.7	+	11	1776	c.1558C>T	c.(1558-1560)Cgg>Tgg	p.R520W	SMTN_ENST00000347557.2_Missense_Mutation_p.R520W|SMTN_ENST00000358743.1_Missense_Mutation_p.R520W	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	520					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						GACCCTGGCTCGGCTGGGCAG	0.662000													14	17					0	0	1	0	0
TRIM35	23087	broad.mit.edu	37	8	27168522	27168522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27168522G>A	ENST00000305364.4	-	1	314	c.231C>T	c.(229-231)aaC>aaT	p.N77N	TRIM35_ENST00000521253.1_Silent_p.N77N	NM_171982.3	NP_741983.2	Q9UPQ4	TRI35_HUMAN	tripartite motif containing 35	77					apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding			breast(1)|endometrium(6)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	14		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		TCTCCACCAGGTTGTTGAGGG	0.697000													5	9					0	0	1	0	0
NXPE1	120400	broad.mit.edu	37	11	114392968	114392968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:114392968C>T	ENST00000536271.1	-	4	1757	c.514G>A	c.(514-516)Ggt>Agt	p.G172S	NXPE1_ENST00000251921.2_Missense_Mutation_p.G314S|NXPE1_ENST00000424269.1_Missense_Mutation_p.G456S					neurexophilin and PC-esterase domain family, member 1																		TTTTGAACACCGATGGCCCTG	0.438000													13	142					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43086883	43086883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43086883G>A	ENST00000267890.6	-	10	1047	c.939C>T	c.(937-939)acC>acT	p.T313T	TTBK2_ENST00000567274.1_Silent_p.T278T|TTBK2_ENST00000567840.1_Silent_p.T313T	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	313	Poly-Thr.		T -> A (in dbSNP:rs56017612).		cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		ACTGAGGGGTGGTAGAAGTAG	0.438000													9	134					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114111003	114111003	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:114111003G>A	ENST00000297405.5	-	5	1143	c.899C>T	c.(898-900)tCt>tTt	p.S300F	CSMD3_ENST00000455883.2_Missense_Mutation_p.S300F|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Missense_Mutation_p.S260F|CSMD3_ENST00000352409.3_Missense_Mutation_p.S300F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	300	CUB 2.					integral to membrane|plasma membrane		p.S300F(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGGTGGCTCAGAACCTTCTAT	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	43					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629474	47629474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:47629474G>A	ENST00000546455.1	+	4	1359	c.628G>A	c.(628-630)Gat>Aat	p.D210N	PCED1B_ENST00000432328.1_Missense_Mutation_p.D210N					PC-esterase domain containing 1B																		ACATAACTTCGATGTACTGGA	0.587000													9	15					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180383269	180383269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:180383269G>A	ENST00000410066.1	-	5	1096	c.493C>T	c.(493-495)Cgc>Tgc	p.R165C	ZNF385B_ENST00000409692.1_Missense_Mutation_p.R63C|ZNF385B_ENST00000336917.5_Missense_Mutation_p.R63C|ZNF385B_ENST00000409343.1_Missense_Mutation_p.R89C|ZNF385B_ENST00000466398.1_5'UTR	NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	165						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GAGTTAAAGCGAAGCTGACAG	0.353000													41	100					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219411757	219411757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219411757G>A	ENST00000258399.3	-	7	899	c.487C>T	c.(487-489)Ctt>Ttt	p.L163F	USP37_ENST00000418019.1_Missense_Mutation_p.L163F|USP37_ENST00000454775.1_Missense_Mutation_p.L163F|USP37_ENST00000338465.5_Missense_Mutation_p.L163F|USP37_ENST00000415516.1_Missense_Mutation_p.L91F	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	163					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		GGATTACCAAGAACTTTTCGA	0.368000													30	104					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85775681	85775681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:85775681C>T	ENST00000383699.3	+	2	698	c.71C>T	c.(70-72)tCa>tTa	p.S24L	CADM2_ENST00000407528.2_Intron|CADM2_ENST00000405615.2_Missense_Mutation_p.S17L	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	20					adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GCGGCTGCTTCAAAGAATAAA	0.353000													20	177					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8692540	8692540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8692540C>T	ENST00000299663.3	-	2	206	c.41G>A	c.(40-42)aGa>aAa	p.R14K	CLEC4E_ENST00000545274.1_Missense_Mutation_p.R14K|CLEC4E_ENST00000446457.2_Missense_Mutation_p.R14K	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	14						integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					GAAGCATCCTCTCTCTGTAGA	0.408000													29	119					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585536	7585536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7585536G>A	ENST00000379802.3	+	24	8382	c.8041G>A	c.(8041-8043)Gac>Aac	p.D2681N	DSP_ENST00000418664.2_Missense_Mutation_p.D2082N	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2681	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGGTGTGATTGACCAAGACAT	0.567000													59	154					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10401959	10401959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10401959C>T	ENST00000226207.5	-	30	4259	c.4165G>A	c.(4165-4167)Gag>Aag	p.E1389K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1389						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TCCTCCAGCTCCTCTGTGCGC	0.478000													51	71					0	0	1	0	0
TTC39A	22996	broad.mit.edu	37	1	51754555	51754555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:51754555C>T	ENST00000447632.2	-	17	1722	c.1674G>A	c.(1672-1674)gaG>gaA	p.E558E	TTC39A_ENST00000451380.1_Silent_p.E522E|TTC39A_ENST00000530004.1_Silent_p.E166E|TTC39A_ENST00000371750.5_Silent_p.E523E|TTC39A_ENST00000534098.1_5'UTR|TTC39A_ENST00000262675.7_Silent_p.E495E|TTC39A_ENST00000413473.2_Silent_p.E526E			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	558							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						TTCTGTCTTGCTCCATAAGCA	0.493000													8	11					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142625942	142625942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142625942G>A	ENST00000265310.1	-	6	954	c.606C>T	c.(604-606)atC>atT	p.I202I	TRPV5_ENST00000442623.1_Silent_p.I202I	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	202					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GGAGGATGAGGATGTGTAATA	0.562000													27	113					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247920864	247920864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247920864G>A	ENST00000408896.2	-	1	1118	c.845C>T	c.(844-846)gCt>gTt	p.A282V		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CAGCATCGGAGCCACCATTGA	0.473000													61	113					0	0	1	0	0
CDH3	1001	broad.mit.edu	37	16	68732150	68732150	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68732150G>T	ENST00000264012.4	+	16	2881	c.2337G>T	c.(2335-2337)gtG>gtT	p.V779V	CDH3_ENST00000429102.2_3'UTR|CDH3_ENST00000581171.1_Silent_p.V724V	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	779					adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CCCTCTTGGTGTTCGACTATG	0.622000													37	92					2.05212e-20	2.06471e-20	1	1	0
MYRF	745	broad.mit.edu	37	11	61533562	61533562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61533562C>T	ENST00000278836.5	+	3	363	c.267C>T	c.(265-267)ccC>ccT	p.P89P	MYRF_ENST00000265460.5_Silent_p.P80P	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		GCCATGGTCCCCTCCCACCCC	0.741000													7	30					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516978	140516978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140516978C>T	ENST00000231134.5	+	1	2179	c.1962C>T	c.(1960-1962)acC>acT	p.T654T		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		654	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCGGCCACCGCCACGCTGC	0.731000													18	119					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53854443	53854443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53854443C>T	ENST00000458035.1	+	4	632	c.515C>T	c.(514-516)tCg>tTg	p.S172L	ZNF845_ENST00000595091.1_Missense_Mutation_p.S172L	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AACAGTGCTTCGTTGGTTTCA	0.393000													44	115					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7581641	7581641	+	Missense_Mutation	SNP	G	G	A	rs142885240	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7581641G>A	ENST00000379802.3	+	23	5559	c.5218G>A	c.(5218-5220)Gaa>Aaa	p.E1740K	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1740	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton	p.E1740K(1)		biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGACGAAGCGAAGCGGACAG	0.507000													46	133					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12121044	12121044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:12121044C>T	ENST00000379388.2	+	4	1348	c.1016C>T	c.(1015-1017)cCt>cTt	p.P339L		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	339					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CTAACTTCACCTTCCAGTAGA	0.433000													65	143					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64570110	64570110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64570110G>A	ENST00000294066.2	-	3	261	c.170C>T	c.(169-171)tCc>tTc	p.S57F	MAP4K2_ENST00000377350.3_Missense_Mutation_p.S57F|MAP4K2_ENST00000468062.1_5'UTR	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2	57	Protein kinase.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						CTGCTGGAGGGAGCTGATGTC	0.612000													4	28					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109672146	109672146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109672146C>T	ENST00000356711.2	+	23	2743	c.2617C>T	c.(2617-2619)Ctc>Ttc	p.L873F	MYO16_ENST00000357550.2_Missense_Mutation_p.L873F|MYO16_ENST00000251041.5_Missense_Mutation_p.L873F|MYO16_ENST00000457511.2_Missense_Mutation_p.L385F	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	873	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACTACAAAGTCTCCTAGAATC	0.423000													11	49					0	0	1	0	0
TBCEL	219899	broad.mit.edu	37	11	120925967	120925967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120925967C>T	ENST00000422003.2	+	5	850	c.662C>T	c.(661-663)tCa>tTa	p.S221L	TBCEL_ENST00000529397.1_Missense_Mutation_p.S221L	NM_152715.3	NP_689928.3	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	221						cytoplasm|cytoskeleton			TECTA/TBCEL(2)	endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		CCTGATGATTCATTGGCCAGG	0.433000													25	48					0	0	1	0	0
PDE4B	5142	broad.mit.edu	37	1	66829101	66829101	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:66829101C>T	ENST00000423207.2	+	10	1571	c.1086C>T	c.(1084-1086)ctC>ctT	p.L362L	PDE4B_ENST00000480109.2_Silent_p.L144L|PDE4B_ENST00000371045.5_Silent_p.L205L|PDE4B_ENST00000371049.3_Silent_p.L377L|PDE4B_ENST00000329654.4_Silent_p.L377L	NM_001037340.1	NP_001032417.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	377					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	AAAGAGACCTCCTAAAGACAT	0.353000													16	49					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6051600	6051600	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6051600C>T	ENST00000409021.3	-	15	2358		c.e15-1		JAKMIP1_ENST00000409371.3_Splice_Site	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1						protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CATTCACATCCTGGAAGAGAT	0.443000													9	21					0	0	1	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153274984	153274984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153274984G>A	ENST00000290722.1	-	5	681	c.629C>T	c.(628-630)gCt>gTt	p.A210V		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	210					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCTTGTGCCAGCGGTGTGGAT	0.488000													45	86					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100268	8100268	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:8100268G>A	ENST00000379328.3	+	3	810	c.241_splice	c.e3-1	p.G81_splice	GATA3_ENST00000346208.3_Splice_Site_p.G81_splice	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	81					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						TGCCCCACAGGGAGCCAGGTG	0.672000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						33	61					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123021952	123021952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123021952C>T	ENST00000462833.1	-	14	3886	c.2674G>A	c.(2674-2676)Gat>Aat	p.D892N	ADCY5_ENST00000309879.5_Missense_Mutation_p.D542N|ADCY5_ENST00000491190.1_Missense_Mutation_p.D525N	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	892					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CCCTGCTCATCGCCCAGGCTG	0.647000													19	40					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107407872	107407872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107407872C>T	ENST00000394872.2	-	40	4261	c.4030G>A	c.(4030-4032)Gac>Aac	p.D1344N	COL4A6_ENST00000372216.4_Missense_Mutation_p.D1344N|COL4A6_ENST00000545689.1_Missense_Mutation_p.D1319N|COL4A6_ENST00000334504.7_Missense_Mutation_p.D1343N|COL4A6_ENST00000538570.1_Intron			Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1344	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						AATCCTGGGTCTCCAGGTGGC	0.597000									Alport syndrome with Diffuse Leiomyomatosis				62	43					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431918	56431918	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56431918G>A	ENST00000302969.2	+	1	781	c.757G>A	c.(757-759)Ggc>Agc	p.G253S		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						CCTCTTCTATGGCACAGTCAT	0.498000													8	104					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40411940	40411940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40411940C>T	ENST00000221347.6	-	7	3695	c.3688G>A	c.(3688-3690)Gga>Aga	p.G1230R		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1230	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTGCGGTCCGCAGCTGGAG	0.667000													20	51					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117665278	117665278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117665278C>T	ENST00000317775.6	-	23	4259	c.3574G>A	c.(3574-3576)Gaa>Aaa	p.E1192K	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.E1226K	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1192	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGGTGCACTTCATCAGGGTAC	0.622000													17	37					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91404546	91404546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:91404546G>A	ENST00000370440.1	-	3	2582	c.2365C>T	c.(2365-2367)Cct>Tct	p.P789S	ZNF644_ENST00000467231.1_Intron|ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.P789S|ZNF644_ENST00000347275.5_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	789					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		GGCTTATGAGGGTCTGAAATA	0.358000													30	76					0	0	1	0	0
CCDC50	152137	broad.mit.edu	37	3	191107287	191107287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:191107287C>T	ENST00000392455.3	+	10	1395	c.797C>T	c.(796-798)cCa>cTa	p.P266L	CCDC50_ENST00000392456.3_Missense_Mutation_p.P442L	NM_174908.3	NP_777568.1	Q8IVM0	CCD50_HUMAN	coiled-coil domain containing 50	266	Poly-Pro.					cytoplasm	protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|stomach(1)	23	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		CCTTTTAGGCCACCACCACCT	0.418000													65	148					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37725472	37725472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37725472C>T	ENST00000264741.5	+	18	2289	c.2033C>T	c.(2032-2034)tCc>tTc	p.S678F		NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	678					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TTCAATGTTTCCCGGGAGCTC	0.473000													16	38					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81545644	81545644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81545644G>A	ENST00000548058.1	+	6	1853	c.943G>A	c.(943-945)Gga>Aga	p.G315R	ACSS3_ENST00000548324.1_5'UTR|ACSS3_ENST00000261206.3_Missense_Mutation_p.G314R			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	315						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GCCCACTGGGGGATACGCTGT	0.383000													16	87					0	0	1	0	0
TEC	7006	broad.mit.edu	37	4	48230567	48230567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48230567G>A	ENST00000381501.3	-	2	222	c.65C>T	c.(64-66)tCg>tTg	p.S22L		NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	22	PH.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						GTTTAAGGGCGATGTCTTCTT	0.388000													46	85					0	0	1	0	0
HAUS7	55559	broad.mit.edu	37	X	152728076	152728076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:152728076G>A	ENST00000370219.3	-	4	933	c.376C>T	c.(376-378)Ctc>Ttc	p.L126F	HAUS7_ENST00000370210.1_Missense_Mutation_p.L116F|HAUS7_ENST00000421080.2_5'UTR|TREX2_ENST00000334497.2_5'UTR|TREX2_ENST00000338525.2_5'UTR|HAUS7_ENST00000370211.4_Missense_Mutation_p.L116F|TREX2_ENST00000370232.1_5'UTR|HAUS7_ENST00000370212.3_Missense_Mutation_p.L126F|TREX2_ENST00000330912.2_5'UTR	NM_017518.6	NP_059988.3	Q99871	HAUS7_HUMAN	HAUS augmin-like complex, subunit 7	126					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding			endometrium(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)	19						ACCTTGAGGAGCTCCTGGTCA	0.587000													12	12					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815707	158815707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158815707G>A	ENST00000368141.4	+	5	1162	c.901G>A	c.(901-903)Gaa>Aaa	p.E301K		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	301	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					CAGAATTATCGAAATAGCAAA	0.338000													39	92					0	0	1	0	0
MUC5AC	4586	broad.mit.edu	37	11	1162237	1162237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1162237C>T	ENST00000356191.2	+	20	1737	c.1737C>T	c.(1735-1737)ttC>ttT	p.579_579insF						mucin 5AC, oligomeric mucus/gel-forming											NS(1)|breast(2)|central_nervous_system(7)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(5)|kidney(9)|large_intestine(19)|liver(1)|lung(89)|ovary(7)|prostate(8)|skin(9)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	203		all_cancers(49;2.94e-05)|Breast(177;0.00257)|all_epithelial(84;0.00314)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00146)|Lung(200;0.0612)|LUSC - Lung squamous cell carcinoma(625;0.0724)		CCGATGACTTCCGGACCCTCA	0.637000													8	17					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774731	122774731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:122774731C>T	ENST00000227349.2	+	3	740	c.443C>T	c.(442-444)cCg>cTg	p.P148L	C11orf63_ENST00000307257.6_Missense_Mutation_p.P148L|C11orf63_ENST00000531316.1_Missense_Mutation_p.P148L	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	148										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GAAGCGTTGCCGGAGTCCACG	0.527000													49	143					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94772593	94772593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94772593G>A	ENST00000283357.5	+	7	922	c.876G>A	c.(874-876)atG>atA	p.M292I		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	292										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GCCACGAAATGAACCTTTTGG	0.378000													15	44					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275534	152275534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152275534C>T	ENST00000368799.1	-	3	11863	c.11828G>A	c.(11827-11829)gGa>gAa	p.G3943E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3943	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTGTATTCCTGAGTGATA	0.433000									Ichthyosis				46	88					0	0	1	0	0
TXK	7294	broad.mit.edu	37	4	48076025	48076025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48076025G>A	ENST00000264316.4	-	13	1369	c.1284C>T	c.(1282-1284)ttC>ttT	p.F428F	TXK_ENST00000507351.1_Silent_p.F83F	NM_003328.2	NP_003319.2	P42681	TXK_HUMAN	TXK tyrosine kinase	428	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(2)	25						ACTTGATTGGGAACTTGGCTC	0.388000													9	90					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98186452	98186452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:98186452G>A	ENST00000306031.5	-	6	640	c.514C>T	c.(514-516)Cat>Tat	p.H172Y	DPYD_ENST00000474241.1_5'UTR|DPYD_ENST00000423006.2_Intron|DPYD_ENST00000370192.3_Intron	NM_001160301.1	NP_001153773.1	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	0					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CTTTACAAATGATTCATTAAA	0.338000													4	23					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31654358	31654358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31654358G>A	ENST00000331728.4	+	3	312	c.198G>A	c.(196-198)ggG>ggA	p.G66G	LIMK2_ENST00000406516.1_5'UTR|LIMK2_ENST00000340552.4_Silent_p.G45G|LIMK2_ENST00000333611.4_Silent_p.G45G|LIMK2_ENST00000444929.2_Intron	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	66						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						ACTACTGGGGGAAGTTTGGGG	0.512000													41	56					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31317894	31317894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31317894G>A	ENST00000265071.2	+	11	2010	c.1745G>A	c.(1744-1746)gGg>gAg	p.G582E	CDH6_ENST00000514738.1_Missense_Mutation_p.G527E	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	582	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AGCAGCACTGGGACAGTGACT	0.542000													22	49					0	0	1	0	0
MT1L	4500	broad.mit.edu	37	16	56651395	56651395	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56651395G>A	ENST00000565768.1	+	0	8					NR_001447.2				metallothionein 1L (gene/pseudogene)																		CCTGCAAAAGGAGCAGCTGGC	0.662000													14	28					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95847290	95847290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95847290C>T	ENST00000398107.2	+	4	1113	c.591C>T	c.(589-591)ttC>ttT	p.F197F	ZNF2_ENST00000340539.5_Silent_p.F239F|ZNF2_ENST00000295210.6_Silent_p.F201F|ZNF2_ENST00000453539.2_Silent_p.F252F|ZNF2_ENST00000425369.1_Silent_p.F159F	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		CAAAAGCCTTCTTTGACCGTT	0.522000													16	131					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50781399	50781399	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50781399G>A	ENST00000440075.2	+	30	3932	c.3885G>A	c.(3883-3885)cgG>cgA	p.R1295R	MYH14_ENST00000425460.1_Silent_p.R1262R|MYH14_ENST00000262269.8_Silent_p.R1295R|MYH14_ENST00000376970.2_Silent_p.R1287R|MYH14_ENST00000598205.1_Silent_p.R1262R|MYH14_ENST00000596571.1_Silent_p.R1254R|MYH14_ENST00000601313.1_Silent_p.R1295R			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1254					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CCGAGCTGCGGGCAGAACTGA	0.642000													7	25					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18384706	18384706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18384706G>A	ENST00000441493.2	-	5	981	c.629C>T	c.(628-630)cCt>cTt	p.P210L	MICAL3_ENST00000207726.7_Missense_Mutation_p.P210L|MICAL3_ENST00000400561.2_Missense_Mutation_p.P210L|MICAL3_ENST00000414725.2_Missense_Mutation_p.P210L|MICAL3_ENST00000429452.1_Missense_Mutation_p.P210L|MICAL3_ENST00000585038.1_Missense_Mutation_p.P210L|MICAL3_ENST00000444520.1_Missense_Mutation_p.P210L|MICAL3_ENST00000383094.3_Missense_Mutation_p.P210L	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	210						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CTCTGACACAGGATGAGTCTT	0.537000													13	26					0	0	1	0	0
MOGAT2	80168	broad.mit.edu	37	11	75442214	75442214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75442214C>T	ENST00000526712.1	+	5	1415	c.642C>T	c.(640-642)ccC>ccT	p.P214P	MOGAT2_ENST00000198801.5_Silent_p.P296P			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	296					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					CGCTGCATCCCTCGGAGGAGG	0.577000													24	60					0	0	1	0	0
MYSM1	114803	broad.mit.edu	37	1	59126874	59126874	+	Missense_Mutation	SNP	G	G	A	rs141454457		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:59126874G>A	ENST00000472487.1	-	19	2335	c.2296C>T	c.(2296-2298)Cgc>Tgc	p.R766C	MYSM1_ENST00000493821.1_5'UTR	NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	766					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.R766C(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					GAATCCCGGCGAAAGATTTTA	0.363000													23	50					0	0	1	0	0
WDR47	22911	broad.mit.edu	37	1	109538218	109538218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109538218G>A	ENST00000357672.3	-	7	1966	c.1591C>T	c.(1591-1593)Cct>Tct	p.P531S	WDR47_ENST00000400794.3_Missense_Mutation_p.P567S|WDR47_ENST00000369962.3_Missense_Mutation_p.P559S|WDR47_ENST00000369965.4_Missense_Mutation_p.P560S|WDR47_ENST00000361054.3_Missense_Mutation_p.P531S			O94967	WDR47_HUMAN	WD repeat domain 47	559										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CTTCCACAAGGTGATTCCTCC	0.363000													74	225					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1092165	1092165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1092165G>A	ENST00000441003.2	+	30	4011	c.3984G>A	c.(3982-3984)ggG>ggA	p.G1328G	MUC2_ENST00000359061.5_Silent_p.G1329G	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1328						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CATTTGATGGGGTCTGCGGGG	0.587000													7	20					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2855544	2855544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2855544G>A	ENST00000520002.1	-	55	8924	c.8369C>T	c.(8368-8370)cCc>cTc	p.P2790L	CSMD1_ENST00000542608.1_Missense_Mutation_p.P2731L|CSMD1_ENST00000400186.3_Missense_Mutation_p.P2732L|CSMD1_ENST00000602557.1_Missense_Mutation_p.P2790L|CSMD1_ENST00000537824.1_Missense_Mutation_p.P2789L|CSMD1_ENST00000602723.1_Missense_Mutation_p.P2732L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2790	Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCGACACGTGGGCAGAGGGCT	0.552000													9	29					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12979590	12979590	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12979590G>A	ENST00000251472.4	+	21	2739	c.2700G>A	c.(2698-2700)aaG>aaA	p.K900K		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	900					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CAGTAGAGAAGAGGCCTTCTC	0.592000													9	147					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013479	73013479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73013479G>A	ENST00000308744.6	+	4	1617	c.1519G>A	c.(1519-1521)Gaa>Aaa	p.E507K	NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000358749.3_Missense_Mutation_p.E405K|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000395999.1_Missense_Mutation_p.E408K	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	507					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			ACCCCAACAGGAATTAGTGAT	0.348000													22	61					0	0	1	0	0
TSKU	25987	broad.mit.edu	37	11	76506753	76506753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76506753C>T	ENST00000527881.1	+	2	1119	c.93C>T	c.(91-93)ttC>ttT	p.F31F	TSKU_ENST00000333090.4_Silent_p.F31F			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	31	LRRNT.					extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					TGGAGACCTTCGGCCTTTTCG	0.672000													7	61					0	0	1	0	0
HPD	3242	broad.mit.edu	37	12	122281721	122281721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122281721C>T	ENST00000543163.1	-	13	1177	c.732G>A	c.(730-732)gaG>gaA	p.E244E	HPD_ENST00000289004.4_Silent_p.E283E	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	283					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	CCAGGCCTCTCTCTCTCAAGT	0.532000													23	39					0	0	1	0	0
CLDN19	149461	broad.mit.edu	37	1	43203960	43203960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43203960G>A	ENST00000296387.1	-	3	603	c.413C>T	c.(412-414)tCg>tTg	p.S138L	CLDN19_ENST00000539749.1_Intron|CLDN19_ENST00000372539.3_Missense_Mutation_p.S138L	NM_001123395.1|NM_148960.2	NP_001116867.1|NP_683763.2	Q8N6F1	CLD19_HUMAN	claudin 19	138					calcium-independent cell-cell adhesion|response to stimulus|visual perception	basolateral plasma membrane|integral to membrane|tight junction	identical protein binding			breast(2)|large_intestine(1)|lung(2)|skin(1)	6	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGCATACCACGAGACAGCAGT	0.612000													15	71					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71907116	71907116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71907116G>A	ENST00000393679.1	+	5	1105	c.669G>A	c.(667-669)gaG>gaA	p.E223E	FOLR1_ENST00000393676.3_Silent_p.E223E|FOLR1_ENST00000312293.4_Silent_p.E223E|RP11-807H22.7_ENST00000378140.3_RNA|FOLR1_ENST00000393681.2_Silent_p.E223E			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	223					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						ACCCCAATGAGGAGGTGGCGA	0.607000													13	69					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61986905	61986905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:61986905C>T	ENST00000409186.1	-	5	3432	c.1327G>A	c.(1327-1329)Gaa>Aaa	p.E443K	PCDH20_ENST00000409204.4_Missense_Mutation_p.E443K			Q8N6Y1	PCD20_HUMAN	protocadherin 20	416	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGTTCCAGTTCTTTCAGATAA	0.418000													35	103					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066875	46066875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46066875C>T	ENST00000334670.8	+	1	545	c.500C>T	c.(499-501)tCa>tTa	p.S167L	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	161	25 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						GATTCCTCTTCATGCTGCCAG	0.617000													63	253					0	0	1	0	0
AADACL3	126767	broad.mit.edu	37	1	12785679	12785679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12785679G>A	ENST00000332530.3	+	3	785	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K	AADACL3_ENST00000359318.5_Missense_Mutation_p.E257K	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	257							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTTACTTGGAAGTAAGTGT	0.502000													63	120					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325407	47325407	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47325407G>A	ENST00000505841.1	-	0	1122					NR_002788.2																						GCGTAGAGGCGGAGGCATTCC	0.493000													20	87					0	0	1	0	0
SLC30A1	7779	broad.mit.edu	37	1	211749497	211749497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:211749497G>A	ENST00000367001.4	-	2	886	c.757C>T	c.(757-759)Ctt>Ttt	p.L253F		NM_021194.2	NP_067017.2	Q9Y6M5	ZNT1_HUMAN	solute carrier family 30 (zinc transporter), member 1	253					cadmium ion transmembrane transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|negative regulation of calcium ion import|negative regulation of neurotransmitter secretion|negative regulation of zinc ion import	integral to membrane|T-tubule	calcium channel inhibitor activity|zinc ion transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(3)|prostate(1)	11				OV - Ovarian serous cystadenocarcinoma(81;0.00535)|GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.0604)|Epithelial(68;0.0978)		GCATCTCCAAGGACATGCAGA	0.413000													25	77					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2376115	2376115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2376115G>A	ENST00000301732.5	-	5	915	c.215C>T	c.(214-216)cCt>cTt	p.P72L	ABCA3_ENST00000567910.1_Missense_Mutation_p.P72L|ABCA3_ENST00000382381.3_Missense_Mutation_p.P72L	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	72					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				TCCTGGCGGAGGGAAGGTGAA	0.577000													10	50					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446015	10446015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:10446015G>A	ENST00000326756.3	-	3	2376	c.1938C>T	c.(1936-1938)gtC>gtT	p.V646V		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TGCCCTCGGGGACATTTTCAG	0.408000													50	147					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111138100	111138100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111138100C>T	ENST00000360467.5	+	34	3430	c.3124C>T	c.(3124-3126)Ccc>Tcc	p.P1042S		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1042	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CATCGGAGTCCCCGGCATCCC	0.617000													30	63					0	0	1	0	0
RMND5A	64795	broad.mit.edu	37	2	86980590	86980590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:86980590C>T	ENST00000283632.4	+	4	925	c.430C>T	c.(430-432)Ctt>Ttt	p.L144F		NM_022780.3	NP_073617.1	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	144	LisH.									kidney(1)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	17						GGAATCTGGTCTTTCTGTAGA	0.373000													45	96					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117810748	117810748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117810748G>A	ENST00000350763.4	-	16	5054	c.4643C>T	c.(4642-4644)tCc>tTc	p.S1548F	TNC_ENST00000535648.1_Intron|TNC_ENST00000481475.1_5'UTR|TNC_ENST00000542877.1_Intron|TNC_ENST00000423613.2_Intron|TNC_ENST00000346706.3_Intron|TNC_ENST00000537320.1_Intron|TNC_ENST00000341037.4_Intron|TNC_ENST00000345230.3_Intron|TNC_ENST00000340094.3_Missense_Mutation_p.S1184F	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1548	Fibronectin type-III 11.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TGCCATCCAGGAAACTGTGAA	0.502000													9	40					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3101050	3101050	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3101050C>T	ENST00000355072.5	+	3	542	c.397C>T	c.(397-399)Ctg>Ttg	p.L133L		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	133					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGAACTTTTTCTGCTGTGCAG	0.438000													9	88					0	0	1	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516120	138516120	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138516120G>A	ENST00000371763.1	-	5	907	c.654C>T	c.(652-654)atC>atT	p.I218I		NM_182974.2	NP_892019.2	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	218					carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	15		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		GTCCAAACGGGATGCAAGCTG	0.493000													18	100					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23224167	23224167	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23224167G>T	ENST00000300061.2	+	10	1526	c.1383G>T	c.(1381-1383)gaG>gaT	p.E461D	CTC-391G2.1_ENST00000563471.1_RNA	NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	461				EWT -> DGH (in Ref. 5; AAC50758).	excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GCTTTAAAGAGTGGACACTAA	0.592000													10	72					1.58986e-06	1.59347e-06	1	1	0
COL17A1	1308	broad.mit.edu	37	10	105840406	105840406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105840406C>T	ENST00000353479.5	-	2	316	c.26G>A	c.(25-27)cGa>cAa	p.R9Q	COL17A1_ENST00000369733.3_Missense_Mutation_p.R9Q|COL17A1_ENST00000393211.3_Missense_Mutation_p.R9Q	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	9	Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGTTCCATCTCGTTTGTTTTT	0.308000													32	87					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103326685	103326685	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:103326685T>A	ENST00000376052.3	+	28	3440	c.3424T>A	c.(3424-3426)Tgt>Agt	p.C1142S	TPP2_ENST00000466153.1_3'UTR|TPP2_ENST00000376065.4_Missense_Mutation_p.C1129S			P29144	TPP2_HUMAN	tripeptidyl peptidase II	1129					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TAGGAAAGGTTGTGCCCTGGC	0.433000													25	59					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703443	55703443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55703443C>T	ENST00000301532.3	-	1	433	c.434G>A	c.(433-435)cGg>cAg	p.R145Q		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GACAATCAACCGCATACAGAT	0.428000													29	71					0	0	1	0	0
C4orf17	84103	broad.mit.edu	37	4	100443816	100443816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100443816G>A	ENST00000514652.1	+	3	641	c.287G>A	c.(286-288)gGa>gAa	p.G96E	C4orf17_ENST00000326581.4_Missense_Mutation_p.G96E|C4orf17_ENST00000503257.1_3'UTR			Q53FE4	CD017_HUMAN	chromosome 4 open reading frame 17	96										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		CCTGTAAGAGGAATGTCGCCA	0.507000													24	85					0	0	1	0	0
MLNR	2862	broad.mit.edu	37	13	49796481	49796481	+	Missense_Mutation	SNP	G	G	A	rs141878008		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:49796481G>A	ENST00000218721.1	+	2	1207	c.1207G>A	c.(1207-1209)Gag>Aag	p.E403K	MLNR_ENST00000398307.1_3'UTR	NM_001507.1	NP_001498.1	O43193	MTLR_HUMAN	motilin receptor	403					digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity			endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)	14		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		GGGCTACACCGAGACAAGCGC	0.572000													4	20					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	818396	818396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:818396G>A	ENST00000566549.1	+	16	2031	c.1614G>A	c.(1612-1614)gaG>gaA	p.E538E	MSLN_ENST00000382862.3_Silent_p.E546E|MSLN_ENST00000545450.2_Silent_p.E538E|MSLN_ENST00000563941.1_Silent_p.E538E			Q13421	MSLN_HUMAN	mesothelin	546					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				CTGTGGCTGAGGTGCAGAAAC	0.682000													10	25					0	0	1	0	0
CD19	930	broad.mit.edu	37	16	28944640	28944640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28944640C>T	ENST00000538922.1	+	4	707	c.645C>T	c.(643-645)acC>acT	p.T215T	CD19_ENST00000567541.1_Silent_p.T215T|CD19_ENST00000324662.3_Silent_p.T215T	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	215	Ig-like C2-type 2.				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						TCTCCTGGACCCATGTGCACC	0.622000													17	33					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179449278	179449278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179449278C>T	ENST00000589042.1	-	311	65224	c.65000G>A	c.(64999-65001)cGa>cAa	p.R21667Q	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R19099Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R20026Q|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R12794Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R12727Q|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R12602Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20026	Fibronectin type-III 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R12794P(1)|p.R19099P(1)|p.R19097P(1)|p.R12602P(1)|p.R12727P(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTGACTCGTGCATTCTT	0.398000													27	48					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125284084	125284084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:125284084G>A	ENST00000521654.2	+	1	394	c.394G>A	c.(394-396)Gag>Aag	p.E132K	RP11-510H23.1_ENST00000439075.1_RNA|RNF217_ENST00000560949.1_5'UTR			Q8TC41	RN217_HUMAN	ring finger protein 217	0					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		CCCCGGCGAAGAGCTGGAGCC	0.672000													6	19					0	0	1	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89476605	89476605	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89476605G>A	ENST00000484817.1	-	0	39																											AGCTGAGCAAGGAGCCTCATT	0.552000													5	27					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1230951	1230951	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:1230951C>T	ENST00000381312.1	-	9	2218	c.1893G>A	c.(1891-1893)ccG>ccA	p.P631P	ADARB2_ENST00000381305.1_Silent_p.P33P|ADARB2_ENST00000381310.3_Silent_p.P140P	NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	631	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCGACTTCCCCGGCTGGCGCG	0.682000													6	39					0	0	1	0	0
ZNF610	162963	broad.mit.edu	37	19	52869802	52869802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52869802C>T	ENST00000601151.1	+	5	1494	c.1042C>T	c.(1042-1044)Ctt>Ttt	p.L348F	ZNF610_ENST00000403906.3_Missense_Mutation_p.L391F|ZNF610_ENST00000321287.8_Missense_Mutation_p.L391F|ZNF610_ENST00000327920.8_Missense_Mutation_p.L391F	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		TATGGCCCATCTTCTAATCCA	0.413000													21	71					0	0	1	0	0
GNL2	29889	broad.mit.edu	37	1	38034744	38034744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38034744G>A	ENST00000373062.3	-	13	1674	c.1576C>T	c.(1576-1578)Ctc>Ttc	p.L526F	GNL2_ENST00000462812.1_5'UTR	NM_013285.2	NP_037417.1	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2 (nucleolar)	526					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				ACTCGTGTGAGAATCTGCTGC	0.473000													36	81					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4950860	4950860	+	Missense_Mutation	SNP	C	C	T	rs149764746	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4950860C>T	ENST00000345988.2	-	6	666	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K	PPL_ENST00000590782.2_Missense_Mutation_p.E191K	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	193					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GCCCGGAGTTCGCTGTTCTGC	0.657000													56	207					0	0	1	0	0
SDF2L1	23753	broad.mit.edu	37	22	21998345	21998345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21998345C>T	ENST00000248958.4	+	3	623	c.547C>T	c.(547-549)Cgt>Tgt	p.R183C		NM_022044.2	NP_071327.2	Q9HCN8	SDF2L_HUMAN	stromal cell-derived factor 2-like 1	183	MIR 3.					endoplasmic reticulum lumen|membrane				prostate(1)	1	Colorectal(54;0.105)					AAGCCCCATCCGTGGGCAGCA	0.602000											OREG0026342	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	30					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30961695	30961695	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30961695G>A	ENST00000311813.4	+	2	454	c.399G>A	c.(397-399)gtG>gtA	p.V133V	AQP1_ENST00000434909.2_Silent_p.V193V|AQP1_ENST00000441328.2_Silent_p.V50V|AQP1_ENST00000409899.1_Silent_p.V18V|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Silent_p.V82V|AQP1_ENST00000509504.1_Silent_p.V310V	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				CTGATGGTGTGAACTCGGGCC	0.652000													29	77					0	0	1	0	0
CXCR2P1	3580	broad.mit.edu	37	2	218925040	218925040	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:218925040G>A	ENST00000439871.1	-	0	1340					NR_002712.1																						AACCCCACGGGACTGCACTTA	0.552000													25	81					0	0	1	0	0
ZSCAN23	222696	broad.mit.edu	37	6	28403922	28403922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28403922G>A	ENST00000289788.4	-	2	267	c.122C>T	c.(121-123)cCt>cTt	p.P41L	ZSCAN23_ENST00000486481.1_Intron	NM_001012455.1	NP_001012458.1	Q3MJ62	ZSC23_HUMAN	zinc finger and SCAN domain containing 23	41					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|prostate(1)|stomach(2)	4						TCTGGTATGAGGGTTATTTCT	0.537000													4	10					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239360	5239360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:5239360C>T	ENST00000274181.7	+	15	2389	c.2251C>T	c.(2251-2253)Ctc>Ttc	p.L751F		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	751	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TCACAGGGGTCTCTACACCAA	0.512000													39	152					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105386875	105386875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105386875G>A	ENST00000369774.4	-	9	965	c.689C>T	c.(688-690)tCc>tTc	p.S230F	SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.S230F|SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000538130.1_Missense_Mutation_p.S65F|SH3PXD2A_ENST00000540321.1_Missense_Mutation_p.S97F|SH3PXD2A_ENST00000427662.2_Missense_Mutation_p.S92F			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	230					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GTTGATGTCGGAGTCATCCCG	0.607000													28	83					0	0	1	0	0
HCAR1	27198	broad.mit.edu	37	12	123214755	123214755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123214755C>T	ENST00000432564.1	-	1	374	c.132G>A	c.(130-132)atG>atA	p.M44I	HCAR1_ENST00000436083.2_Missense_Mutation_p.M44I|HCAR1_ENST00000356987.2_Missense_Mutation_p.M44I	NM_032554.3	NP_115943.1	Q9BXC0	HCAR1_HUMAN	hydroxycarboxylic acid receptor 1	44					response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)	10						TCCAGGTCTTCATGTGGAAGC	0.547000													9	27					0	0	1	0	0
KLHL8	57563	broad.mit.edu	37	4	88106515	88106515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88106515G>A	ENST00000273963.5	-	3	994	c.653C>T	c.(652-654)tCc>tTc	p.S218F	KLHL8_ENST00000545252.1_Intron|KLHL8_ENST00000498875.2_Missense_Mutation_p.S142F|KLHL8_ENST00000512111.1_Missense_Mutation_p.S218F|KLHL8_ENST00000425278.2_Intron	NM_020803.3	NP_065854.3	Q9P2G9	KLHL8_HUMAN	kelch-like family member 8	218										breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		ATCACTGGAGGACAAAAGCTT	0.428000													15	139					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214813331	214813331	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:214813331C>T	ENST00000366955.3	+	12	1818	c.1650C>T	c.(1648-1650)tcC>tcT	p.S550S		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	550					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAGAAAACTCCTTGACTTTAG	0.343000													75	169					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19195304	19195304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19195304C>T	ENST00000562034.1	+	3	4401	c.603C>T	c.(601-603)ttC>ttT	p.F201F	SYT17_ENST00000568115.1_Silent_p.F201F|SYT17_ENST00000562711.2_Silent_p.F258F|SYT17_ENST00000355377.2_Silent_p.F262F			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	262	C2 1.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						GCTACACCTTCGAGATCCCCT	0.557000													62	112					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48266805	48266805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48266805C>T	ENST00000302329.3	+	1	198	c.150C>T	c.(148-150)ccC>ccT	p.P50P		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P50P(1)		breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						TTGGTTCCCCCATGTACTTCT	0.488000													31	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438751	179438751	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179438751C>T	ENST00000589042.1	-	326	72332	c.72108G>A	c.(72106-72108)aaG>aaA	p.K24036K	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Silent_p.K21468K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Silent_p.K22395K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Silent_p.K15163K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.K15096K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.K14971K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22395	Fibronectin type-III 74.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACCGTGTCCTTAAATTTAA	0.463000													19	29					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50467665	50467665	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50467665G>A	ENST00000331340.3	+	8	1055	c.900G>A	c.(898-900)gaG>gaA	p.E300E	IKZF1_ENST00000346667.4_Silent_p.E70E|IKZF1_ENST00000357364.4_Silent_p.E213E|IKZF1_ENST00000439701.1_Silent_p.E258E|IKZF1_ENST00000359197.5_Silent_p.E258E|IKZF1_ENST00000438033.1_Silent_p.E213E|IKZF1_ENST00000343574.5_Silent_p.E213E|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000349824.4_Silent_p.E157E	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	300					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CCAGCTACGAGAAGGAGAACG	0.637000			"""D,T"""	BCL6	"""ALL, DLBCL"""								10	27					0	0	1	0	0
CPA5	93979	broad.mit.edu	37	7	129986368	129986368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129986368C>T	ENST00000485477.1	+	2	1171	c.42C>T	c.(40-42)tcC>tcT	p.S14S	CPA5_ENST00000461828.1_Silent_p.S14S|CPA5_ENST00000466363.2_Silent_p.S14S|CPA5_ENST00000431780.2_Silent_p.S14S|CPA5_ENST00000474905.1_Silent_p.S14S|CPA5_ENST00000393213.3_Silent_p.S14S|CPA5_ENST00000355388.3_Silent_p.S14S			Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5	14					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(2)|breast(2)|endometrium(2)|large_intestine(7)|lung(4)|ovary(3)|pancreas(1)|skin(2)	23	Melanoma(18;0.0435)					CTGGGCCATCCCCCGTGGACA	0.632000													25	88					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14857646	14857646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14857646G>A	ENST00000380881.4	-	6	1548	c.733C>T	c.(733-735)Ctt>Ttt	p.L245F	FREM1_ENST00000380880.3_Missense_Mutation_p.L245F|FREM1_ENST00000422223.2_Missense_Mutation_p.L245F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	245					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TGATAACGAAGGCCCATCAGC	0.473000													32	61					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24448182	24448182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24448182G>A	ENST00000230036.1	-	17	1711	c.1601C>T	c.(1600-1602)tCc>tTc	p.S534F		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	534				VIGS -> MLGT (in Ref. 6; AA sequence).		extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TGCAAAAGGGGAGCCGATGAC	0.532000													16	55					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167272581	167272581	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167272581C>T	ENST00000308378.3	-	6	962	c.657G>A	c.(655-657)tgG>tgA	p.W219*	WDR49_ENST00000453925.2_Nonsense_Mutation_p.W272*|WDR49_ENST00000479765.1_Intron|WDR49_ENST00000476376.1_Nonsense_Mutation_p.W44*	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	219										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CATTGAAGTCCCATATCTTTA	0.318000													42	97					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53104125	53104125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:53104125C>T	ENST00000408890.4	+	1	777	c.761C>T	c.(760-762)tCc>tTc	p.S254F		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	254										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GCTTGGCCTTCCGTGCTGGTC	0.637000													33	61					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65008433	65008433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65008433C>T	ENST00000247207.6	+	1	1248	c.866C>T	c.(865-867)tCg>tTg	p.S289L	HSPA2_ENST00000394709.1_Missense_Mutation_p.S289L	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	289					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GAGATCGACTCGCTCTACGAG	0.667000													8	19					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26695003	26695003	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26695003C>T	ENST00000396005.3	-	14	1962	c.1653G>A	c.(1651-1653)aaG>aaA	p.K551K		NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	551					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						TTTTGTACTTCTTAGACCAAA	0.388000													54	143					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32145279	32145279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32145279G>A	ENST00000373672.3	-	42	3242	c.2726C>T	c.(2725-2727)cCa>cTa	p.P909L	COL16A1_ENST00000271069.6_Missense_Mutation_p.P908L|COL16A1_ENST00000373668.3_Missense_Mutation_p.P893L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	909	Triple-helical region 4 (COL4) with 2 imperfections.		P -> L (in dbSNP:rs2229804).		cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGAATACCTGGTGGACCCTG	0.627000													46	140					0	0	1	0	0
POMT2	29954	broad.mit.edu	37	14	77750178	77750178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77750178G>A	ENST00000261534.4	-	15	1817	c.1615C>T	c.(1615-1617)Cct>Tct	p.P539S		NM_013382.5	NP_037514.2	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	539					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		AAGATCTCAGGAAAACTGGGC	0.473000													34	84					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52573812	52573812	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52573812C>T	ENST00000395489.2	-	12	1527	c.1131G>A	c.(1129-1131)atG>atA	p.M377I	A1CF_ENST00000395495.1_Missense_Mutation_p.M329I|A1CF_ENST00000373993.1_Missense_Mutation_p.M384I|A1CF_ENST00000374001.1_Intron|ASAH2B_ENST00000483649.1_Intron|A1CF_ENST00000373995.3_Intron|A1CF_ENST00000493415.1_Intron|A1CF_ENST00000373997.3_Intron|A1CF_ENST00000282641.2_Missense_Mutation_p.M384I	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	384	Required for nuclear localization.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CAGGTACATTCATGTAAATTT	0.468000													26	65					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247836280	247836280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247836280C>T	ENST00000359688.2	-	1	85	c.64G>A	c.(64-66)Gga>Aga	p.G22R	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AAGATAATTCCCTGGAGTTCA	0.423000													37	72					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220168485	220168485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220168485G>A	ENST00000295718.2	-	4	589	c.349C>T	c.(349-351)Cgc>Tgc	p.R117C	PTPRN_ENST00000409251.3_Missense_Mutation_p.R117C|AC114803.3_ENST00000417355.1_RNA|PTPRN_ENST00000423636.2_Missense_Mutation_p.R27C	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	117					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCTGGGGGGCGAAGCCTGGGG	0.542000													12	36					0	0	1	0	0
NDRG4	65009	broad.mit.edu	37	16	58538273	58538273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58538273C>T	ENST00000394282.4	+	6	822	c.415C>T	c.(415-417)Ccc>Tcc	p.P139S	NDRG4_ENST00000566192.1_Missense_Mutation_p.P87S|NDRG4_ENST00000568640.1_Missense_Mutation_p.P105S|NDRG4_ENST00000356752.4_Missense_Mutation_p.P117S|NDRG4_ENST00000563799.1_Missense_Mutation_p.P105S|NDRG4_ENST00000570248.1_Missense_Mutation_p.P87S|NDRG4_ENST00000394279.2_Missense_Mutation_p.P119S|NDRG4_ENST00000562999.1_Missense_Mutation_p.P87S|NDRG4_ENST00000258187.5_Missense_Mutation_p.P119S|NDRG4_ENST00000569923.1_Missense_Mutation_p.P32S	NM_001130487.1	NP_001123959.1	Q9ULP0	NDRG4_HUMAN	NDRG family member 4	87					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						GTACCAGTTCCCCTCCATGGA	0.677000													66	164					0	0	1	0	0
DUSP26	78986	broad.mit.edu	37	8	33454981	33454981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:33454981G>A	ENST00000256261.4	-	2	570	c.53C>T	c.(52-54)tCc>tTc	p.S18F	DUSP26_ENST00000523956.1_Missense_Mutation_p.S18F	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	18						Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		GCTACTCCGGGAGAAGCGGGC	0.552000													10	38					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093412	30093412	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30093412C>T	ENST00000567636.1	+	0	1787					NR_003558.1																						AGCTCCCTTGCTGAACCCTGA	0.527000													12	120					0	0	1	0	0
ISL1	3670	broad.mit.edu	37	5	50679518	50679518	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50679518G>A	ENST00000230658.7	+	1	598	c.13G>A	c.(13-15)Gga>Aga	p.G5R	ISL1_ENST00000511384.1_Missense_Mutation_p.G5R	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	5					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				GGGAGACATGGGAGATCCACC	0.522000													20	54					0	0	1	0	0
TECTB	6975	broad.mit.edu	37	10	114053792	114053792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:114053792C>T	ENST00000369422.3	+	6	644	c.644C>T	c.(643-645)cCc>cTc	p.P215L		NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	215	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		TTCATGTATCCCTTGCAGTGG	0.478000													11	40					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39001159	39001159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39001159G>A	ENST00000355481.4	+	59	9085	c.8954G>A	c.(8953-8955)cGa>cAa	p.R2985Q	RYR1_ENST00000359596.3_Missense_Mutation_p.R2985Q|RYR1_ENST00000360985.3_Missense_Mutation_p.R2985Q	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2985					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.R2985L(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGCAGTGGGCGAGTGGAAAAG	0.562000													20	106					0	0	1	0	0
RPL10L	140801	broad.mit.edu	37	14	47120366	47120366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:47120366G>A	ENST00000298283.3	-	1	662	c.574C>T	c.(574-576)Cct>Tct	p.P192S		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	192					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						CAACCATCAGGGATGAGGCAC	0.517000													41	83					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527500	23527500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:23527500G>A	ENST00000296682.3	+	11	2485	c.2303G>A	c.(2302-2304)aGg>aAg	p.R768K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	768					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGACACCAGAGGACACACACA	0.582000										HNSCC(3;0.000094)			26	197					0	0	1	0	0
SLC25A40	55972	broad.mit.edu	37	7	87466116	87466116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87466116G>A	ENST00000341119.5	-	11	1179	c.833C>T	c.(832-834)cCt>cTt	p.P278L		NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40	278					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					CATATGCAAAGGCATAGAAAC	0.299000													27	47					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3019165	3019165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3019165G>A	ENST00000381127.1	+	8	1226	c.1005G>A	c.(1003-1005)agG>agA	p.R335R	ARSF_ENST00000359361.2_Silent_p.R335R|ARSF_ENST00000537104.1_Silent_p.R335R	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	335						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTGGCCTAAGGAACAACACCC	0.408000													26	19					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043735	20043735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20043735G>A	ENST00000570682.1	-	2	684	c.384C>T	c.(382-384)atC>atT	p.I128I		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	128						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						GGCAGACAGCGATATACCTGT	0.507000													23	72					0	0	1	0	0
MBL1P	8512	broad.mit.edu	37	10	81680793	81680793	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81680793G>A	ENST00000480805.1	+	0	860					NR_002724.2																						CAGGACCTAGGGGCCAAAAAG	0.602000													6	10					0	0	1	0	0
FAM118A	55007	broad.mit.edu	37	22	45719239	45719239	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45719239C>T	ENST00000216214.3	+	4	1065	c.231C>T	c.(229-231)ttC>ttT	p.F77F	FAM118A_ENST00000441876.2_Silent_p.F77F|FAM118A_ENST00000405673.1_Silent_p.F77F	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	77						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TCGCCGAGTTCCGGAGGAAAG	0.592000													11	89					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34100769	34100769	+	Missense_Mutation	SNP	G	G	A	rs452752		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34100769G>A	ENST00000374181.3	-	1	674	c.505C>T	c.(505-507)Ctt>Ttt	p.L169F	GRM4_ENST00000374177.3_Intron|GRM4_ENST00000538487.1_Missense_Mutation_p.L169F	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	169			L -> F (in dbSNP:rs452752).		activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	AAGAGGCGAAGGATGTTGGCC	0.632000													17	29					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771993	143771993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143771993C>T	ENST00000408898.2	+	1	719	c.681C>T	c.(679-681)atC>atT	p.I227I		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					TTCTAAAGATCCAGTCAGGAG	0.478000													27	117					0	0	1	0	0
FKBP2	2286	broad.mit.edu	37	11	64010708	64010708	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64010708T>C	ENST00000394540.3	+	3	679	c.209T>C	c.(208-210)cTg>cCg	p.L70P	FKBP2_ENST00000449942.2_Missense_Mutation_p.L70P|FKBP2_ENST00000309366.4_Missense_Mutation_p.L70P	NM_057092.2	NP_476433.1	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa	70	PPIase FKBP-type.				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			endometrium(2)|lung(3)	5						GACAGCAGCCTGCCCCAGAAC	0.622000													7	57					0	0	1	0	0
GPR84	53831	broad.mit.edu	37	12	54756536	54756536	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54756536G>T	ENST00000551809.1	-	1	1735	c.1100C>A	c.(1099-1101)cCt>cAt	p.P367H	GPR84_ENST00000267015.3_Missense_Mutation_p.P367H|RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA			Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	367						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P367H(1)		NS(1)|breast(2)|kidney(2)|large_intestine(6)|lung(5)|skin(1)|urinary_tract(1)	18						ATAGAGCACAGGGTTGATGCA	0.542000													84	209					2.5963e-48	2.61485e-48	1	1	0
GJA3	2700	broad.mit.edu	37	13	20717051	20717051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:20717051G>A	ENST00000241125.3	-	2	553	c.377C>T	c.(376-378)cCg>cTg	p.P126L		NM_021954.3	NP_068773.2	Q9Y6H8	CXA3_HUMAN	gap junction protein, alpha 3, 46kDa	126					cell-cell signaling|visual perception	connexon complex|integral to membrane				NS(1)|endometrium(1)|kidney(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		all_cancers(29;1.4e-21)|all_epithelial(30;8.75e-19)|all_lung(29;1.28e-17)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000554)|Epithelial(112;0.000872)|OV - Ovarian serous cystadenocarcinoma(117;0.0105)|Lung(94;0.0251)|LUSC - Lung squamous cell carcinoma(192;0.0784)		ATTGTCCTGCGGTGGCTCCTT	0.632000													3	8					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26242107	26242107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26242107C>T	ENST00000335473.7	+	19	3659	c.3409C>T	c.(3409-3411)Cct>Tct	p.P1137S	MYO18B_ENST00000536101.1_Missense_Mutation_p.P1137S|MYO18B_ENST00000407587.2_Missense_Mutation_p.P1138S	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1137	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGCCAAGCTGCCTCCTGTGTG	0.652000													5	18					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105484080	105484080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105484080C>T	ENST00000369774.4	-	5	622	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.E116K			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	116	PX.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CGGAAGACTTCGTCACACTGT	0.552000													14	27					0	0	1	0	0
MIR543	100126335	broad.mit.edu	37	14	101498367	101498367	+	RNA	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101498367A>C	ENST00000390751.1	+	0	44					NR_030619.1																						TTTATTTGTGACGAAACATTC	0.502000													17	67					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31167799	31167799	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31167799C>T	ENST00000349752.5	-	8	1391	c.752G>A	c.(751-753)tGg>tAg	p.W251*	GALNT14_ENST00000406653.1_Nonsense_Mutation_p.W231*|GALNT14_ENST00000356174.3_Nonsense_Mutation_p.W218*|GALNT14_ENST00000324589.5_Nonsense_Mutation_p.W256*|GALNT14_ENST00000420311.2_Nonsense_Mutation_p.W216*|GALNT14_ENST00000486564.1_5'UTR	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	251						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					GTGGAGGCTCCAGTCAAACCC	0.577000													7	72					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614630	247614630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247614630G>A	ENST00000318749.6	-	1	678	c.655C>T	c.(655-657)Ctt>Ttt	p.L219F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	219					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TAGGAGAGAAGGATGAGAGCC	0.582000													11	64					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28710500	28710500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28710500C>T	ENST00000257198.5	-	16	2923	c.2662G>A	c.(2662-2664)Gca>Aca	p.A888T	DSC1_ENST00000257197.3_3'UTR|RP11-408H20.2_ENST00000581836.1_RNA	NM_024421.2	NP_077739.1	Q08554	DSC1_HUMAN	desmocollin 1	888					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CATGTCTTTGCTAATGTCCTA	0.428000													38	185					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79165041	79165041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79165041G>A	ENST00000269392.4	-	22	2973	c.2726C>T	c.(2725-2727)gCc>gTc	p.A909V	AZI1_ENST00000575907.1_Missense_Mutation_p.A873V|AZI1_ENST00000450824.2_Missense_Mutation_p.A906V|AZI1_ENST00000374782.3_Missense_Mutation_p.A870V	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	909					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGCCATGTCGGCCTCCAGCCG	0.652000													37	100					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10433021	10433021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10433021C>T	ENST00000245503.5	-	24	3361	c.2977G>A	c.(2977-2979)Gaa>Aaa	p.E993K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E993K|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	993					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCAATGGTTTCATCCAGACCT	0.502000													87	107					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451832	138451832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138451832C>T	ENST00000344876.4	-	1	1797	c.1411G>A	c.(1411-1413)Gaa>Aaa	p.E471K	PCDH18_ENST00000507846.1_Missense_Mutation_p.E251K|PCDH18_ENST00000412923.2_Missense_Mutation_p.E471K|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	471	Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ATTACAAATTCATATCGGCTT	0.423000													66	185					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13752396	13752396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13752396G>A	ENST00000265104.4	-	64	10979	c.10875C>T	c.(10873-10875)atC>atT	p.I3625I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3625	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTAAAGACGTGATCTAGGAAC	0.423000									Kartagener syndrome				23	69					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214794828	214794828	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:214794828C>T	ENST00000331683.5	+	12	1454	c.1359C>T	c.(1357-1359)tcC>tcT	p.S453S	SPAG16_ENST00000374309.3_Silent_p.S359S	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	453					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TTGTGGCTTCCTCCTCACTGG	0.428000													53	84					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21028279	21028279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21028279C>T	ENST00000381545.3	+	9	1057	c.838C>T	c.(838-840)Ccg>Tcg	p.P280S	SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000540229.1_Missense_Mutation_p.P280S|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.P280S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.P280S	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	280					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TTTTTTCTTGCCGAAAAATCC	0.348000													24	84					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271775	59271775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59271775C>T	ENST00000313253.1	+	1	727	c.727C>T	c.(727-729)Cac>Tac	p.H243Y		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						TTGCACCTCCCACATCACTGT	0.552000													86	216					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166924631	166924631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:166924631G>A	ENST00000061240.2	+	6	1368	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	TLL1_ENST00000513213.1_Missense_Mutation_p.E241K|TLL1_ENST00000507499.1_Missense_Mutation_p.E241K	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	241	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGTTGTTCATGAATTGGGTCA	0.443000													36	96					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95847143	95847143	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95847143C>T	ENST00000398107.2	+	4	966	c.444C>T	c.(442-444)acC>acT	p.T148T	ZNF2_ENST00000340539.5_Silent_p.T190T|ZNF2_ENST00000295210.6_Silent_p.T152T|ZNF2_ENST00000453539.2_Silent_p.T203T|ZNF2_ENST00000425369.1_Silent_p.T110T	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		CATCCCTCACCCGCCATCAGA	0.572000													22	94					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36271373	36271373	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36271373C>T	ENST00000296604.3	-	2	617	c.132G>A	c.(130-132)aaG>aaA	p.K44K	RANBP3L_ENST00000502994.1_Silent_p.K44K|RANBP3L_ENST00000515759.1_Silent_p.K44K	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	44					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TTTGTTCTCCCTTTTCAAAAA	0.303000													10	69					0	0	1	0	0
DOK5	55816	broad.mit.edu	37	20	53205028	53205028	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:53205028G>A	ENST00000262593.5	+	3	531	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	DOK5_ENST00000395939.1_5'UTR	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	61	PH.						insulin receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			TCAGGTTACAGAACTCAATAA	0.408000													41	99					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36870251	36870251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36870251G>A	ENST00000279024.4	-	3	553	c.282C>T	c.(280-282)ccC>ccT	p.P94P		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	94										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GAGGGTTGAGGGGTGCCAAGT	0.572000													25	74					0	0	1	0	0
PSKH2	85481	broad.mit.edu	37	8	87076588	87076588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87076588C>T	ENST00000276616.2	-	2	532	c.458G>A	c.(457-459)gGa>gAa	p.G153E	PSKH2_ENST00000517981.1_5'UTR	NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	153	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			TGTAAAGGATCCCTGAGCAAT	0.488000													17	61					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33916036	33916036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33916036G>A	ENST00000389232.4	+	20	2456	c.2386G>A	c.(2386-2388)Gga>Aga	p.G796R	RYR3_ENST00000415757.3_Missense_Mutation_p.G796R	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	796	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGACGTCATGGAGAGTTTAA	0.403000													12	103					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207640098	207640098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207640098G>A	ENST00000367057.3	+	2	475	c.286G>A	c.(286-288)Gta>Ata	p.V96I	CR2_ENST00000367058.3_Missense_Mutation_p.V96I|CR2_ENST00000458541.2_Missense_Mutation_p.V96I|CR2_ENST00000367059.3_Missense_Mutation_p.V96I	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	96	Sushi 2.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGAGCCCATAGTACCAGGAGG	0.398000													21	112					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633831	32633831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32633831G>A	ENST00000242310.4	-	1	1836	c.1747C>T	c.(1747-1749)Cca>Tca	p.P583S	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	583					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGATTCCATGGATCTTTCACT	0.458000													117	261					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108872051	108872051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108872051C>T	ENST00000329106.2	+	4	423	c.423C>T	c.(421-423)ccC>ccT	p.P141P	SULT1C3_ENST00000376700.1_Silent_p.P141P	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	141						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						CCAGAAATCCCAAGGATTGCC	0.418000													49	111					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111964046	111964046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111964046G>A	ENST00000369732.3	-	8	810	c.755C>T	c.(754-756)cCc>cTc	p.P252L	OVGP1_ENST00000540696.1_Intron|OVGP1_ENST00000481495.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	252					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CTTCTCTGAGGGTGCCCCAAG	0.527000													27	92					0	0	1	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3391706	3391706	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:3391706C>T	ENST00000324266.5	+	2	507	c.312C>T	c.(310-312)ccC>ccT	p.P104P	TRAPPC12_ENST00000382110.2_Silent_p.P104P	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	104							binding										GCCCGGAGCCCGCGGGCACCC	0.771000													4	5					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142655514	142655514	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142655514C>T	ENST00000355265.2	-	5	876	c.400_splice	c.e5-1	p.E134_splice	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	134					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AATTCTGGACCTCTAGAAAGG	0.488000													12	39					0	0	1	0	0
P2RX5-TAX1BP3	100533970	broad.mit.edu	37	17	3594945	3594945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3594945G>A	ENST00000550383.1	-	2	469	c.281C>T	c.(280-282)cCa>cTa	p.P94L	P2RX5_ENST00000225328.5_Missense_Mutation_p.P94L|P2RX5_ENST00000547178.1_Missense_Mutation_p.P94L|P2RX5_ENST00000551178.1_Missense_Mutation_p.P94L|P2RX5_ENST00000552276.1_Missense_Mutation_p.P94L|P2RX5_ENST00000435558.1_Missense_Mutation_p.P94L|P2RX5_ENST00000345901.3_Missense_Mutation_p.P94L|P2RX5_ENST00000552050.1_Missense_Mutation_p.P58L																							GACCTGGGCTGGAATGACGTA	0.617000													22	37					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24811764	24811764	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24811764C>T	ENST00000221169.5	-	0	1694							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TTTTAGGTATCGTGCCATTTC	0.378000													33	134					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200213792	200213792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:200213792C>T	ENST00000443023.1	-	6	2093	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	SATB2_ENST00000457245.1_Missense_Mutation_p.E269K|SATB2_ENST00000428695.1_Missense_Mutation_p.E151K|SATB2_ENST00000260926.5_Missense_Mutation_p.E269K|SATB2_ENST00000417098.1_Missense_Mutation_p.E269K			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	269						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GGAGACTGTTCGTTGGTTTTC	0.498000													30	63					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586118	20586118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20586118C>T	ENST00000315543.4	+	1	553	c.553C>T	c.(553-555)Ctt>Ttt	p.L185F		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTTGGGTCTCCTTCACTCAGG	0.448000													40	78					0	0	1	0	0
FOXO1	2308	broad.mit.edu	37	13	41134284	41134284	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:41134284A>C	ENST00000379561.5	-	2	1728	c.1344T>G	c.(1342-1344)agT>agG	p.S448R		NM_002015.3	NP_002006.2	Q12778	FOXO1_HUMAN	forkhead box O1	448					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX7/FOXO1(197)|PAX3/FOXO1(749)	central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	20		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TACCTCCATAACTCGACTTAT	0.453000													26	51					0	0	1	0	0
SLC9A8	23315	broad.mit.edu	37	20	48471989	48471989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:48471989C>T	ENST00000417961.1	+	8	842	c.632C>T	c.(631-633)tCc>tTc	p.S211F	SLC9A8_ENST00000539601.1_5'UTR|SLC9A8_ENST00000361573.2_Missense_Mutation_p.S195F|SLC9A8_ENST00000541138.1_5'UTR	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	195						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			GCGTTTGGCTCCCTAATATCT	0.438000													47	138					0	0	1	0	0
INA	9118	broad.mit.edu	37	10	105048321	105048321	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105048321G>T	ENST00000369849.4	+	3	1444	c.1395G>T	c.(1393-1395)caG>caT	p.Q465H		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	465	Tail.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		AAACCTCCCAGATAGGGGAAA	0.403000													6	76					0.0215528	0.0215557	1	1	0
LAMA1	284217	broad.mit.edu	37	18	7023190	7023190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:7023190C>T	ENST00000389658.3	-	19	2767	c.2674G>A	c.(2674-2676)Gac>Aac	p.D892N		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	892	Laminin EGF-like 8.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCACAGCGTCCCCATAGAAC	0.567000													10	22					0	0	1	0	0
DBNDD2	55861	broad.mit.edu	37	20	44037095	44037095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44037095C>T	ENST00000372720.3	+	2	513	c.282C>T	c.(280-282)ccC>ccT	p.P94P	SYS1-DBNDD2_ENST00000475242.1_Intron|SYS1-DBNDD2_ENST00000452133.1_Intron|DBNDD2_ENST00000372722.3_Intron|DBNDD2_ENST00000360981.4_Intron|DBNDD2_ENST00000372710.3_Silent_p.P98P|DBNDD2_ENST00000372712.2_Intron|DBNDD2_ENST00000372723.3_Intron|DBNDD2_ENST00000372717.1_Intron|DBNDD2_ENST00000357275.2_Intron	NM_018478.3	NP_060948.3	Q9BQY9	DBND2_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 2	94					negative regulation of protein kinase activity	cytoplasm	protein binding			breast(1)|lung(2)	3		Myeloproliferative disorder(115;0.0122)				CTCCTCTACCCGCAGGAGCTG	0.602000													12	120					0	0	1	0	0
ZNF655	79027	broad.mit.edu	37	7	99171107	99171107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99171107C>T	ENST00000424881.1	+	4	1701	c.1481C>T	c.(1480-1482)aCc>aTc	p.T494I	ZNF655_ENST00000252713.4_Missense_Mutation_p.T459I|ZNF655_ENST00000394163.2_Missense_Mutation_p.T459I|ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000493277.1_Missense_Mutation_p.T494I|ZNF655_ENST00000425063.1_3'UTR	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	459					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GAAGTCCTCACCAGACAGAAA	0.403000													63	168					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532881	84532881	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84532881G>A	ENST00000527857.1	+	0	2903					NR_026851.1																						TATTTCTCAGGGAGATTCCAA	0.428000													9	17					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840182	27840182	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27840182G>A	ENST00000356790.2	+	3	1004	c.759G>A	c.(757-759)gtG>gtA	p.V253V		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	253	MAGE.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AAGATTTGGTGAAAGAAAATT	0.478000													5	26					0	0	1	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18123478	18123478	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:18123478C>T	ENST00000278816.2	+	2	824	c.174C>T	c.(172-174)tcC>tcT	p.S58S	CSRP2BP_ENST00000604915.1_Silent_p.S58S|CSRP2BP_ENST00000377681.2_Silent_p.S58S|CSRP2BP_ENST00000435364.2_Silent_p.S58S|PET117_ENST00000432901.2_3'UTR			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	58					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						GTGGGGATTCCCTCAACAGTG	0.527000													24	65					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600079	29600079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29600079C>T	ENST00000431530.3	+	1	1332	c.1274C>T	c.(1273-1275)tCa>tTa	p.S425L		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	415						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GGCAAAATTTCACCATGTGCA	0.507000													14	23					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56086338	56086338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56086338C>T	ENST00000312711.1	+	1	556	c.556C>T	c.(556-558)Cct>Tct	p.P186S		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					CCCTTTGTTACCTTTGCTTTG	0.328000													7	98					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69719813	69719813	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69719813C>T	ENST00000194900.4	+	18	2496	c.2155C>T	c.(2155-2157)Cag>Tag	p.Q719*	DLG3_ENST00000542398.1_Nonsense_Mutation_p.Q236*|DLG3_ENST00000374360.3_Nonsense_Mutation_p.Q687*|DLG3_ENST00000374355.3_Nonsense_Mutation_p.Q382*|DLG3_ENST00000461646.1_3'UTR			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	687	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					GAAAGATATTCAGGACAACAA	0.488000													9	14					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175063158	175063158	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175063158C>T	ENST00000239462.4	+	7	1470	c.1357C>T	c.(1357-1359)Cga>Tga	p.R453*		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	453	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGTCACTGATCGAGTGACTGA	0.433000													15	48					0	0	1	0	0
EVL	51466	broad.mit.edu	37	14	100563966	100563966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100563966C>T	ENST00000544450.2	+	3	624	c.341C>T	c.(340-342)gCc>gTc	p.A114V	EVL_ENST00000402714.2_Missense_Mutation_p.A108V|EVL_ENST00000392920.3_Missense_Mutation_p.A110V|EVL_ENST00000555048.1_3'UTR			Q9UI08	EVL_HUMAN	Enah/Vasp-like	108					actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				ATGCTGTTTGCCCTGAACATC	0.522000													10	69					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480344	140480344	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140480344G>A	ENST00000231130.2	+	1	111	c.111G>A	c.(109-111)gaG>gaA	p.E37E	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		37	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGTGGCTGAGGAAAAAGAGA	0.512000													7	59					0	0	1	0	0
ACVR1C	130399	broad.mit.edu	37	2	158443811	158443811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158443811G>A	ENST00000243349.7	-	2	552	c.192C>T	c.(190-192)gtC>gtT	p.V64V	ACVR1C_ENST00000335450.7_Silent_p.V64V|ACVR1C_ENST00000348328.5_Silent_p.V64V|ACVR1C_ENST00000409680.3_Silent_p.V14V	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	64					apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						CTGGAAGGGAGACACAGGATT	0.423000													98	264					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31235609	31235609	+	Missense_Mutation	SNP	G	G	A	rs112486041		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31235609G>A	ENST00000322122.3	+	7	1251	c.967G>A	c.(967-969)Gag>Aag	p.E323K		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	323	B30.2/SPRY.				exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						GCCGGCCGGGGAGGACCCGCG	0.706000													9	20					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235236	5235236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:5235236G>A	ENST00000274181.7	+	13	2098	c.1960G>A	c.(1960-1962)Gag>Aag	p.E654K	ADAMTS16_ENST00000513709.1_3'UTR	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	654	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TCAGTGTGCCGAGCACAACAG	0.527000													23	63					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46903410	46903410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:46903410C>T	ENST00000378623.1	-	20	2899	c.2657G>A	c.(2656-2658)cGa>cAa	p.R886Q		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	886					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CATGCCAGCTCGTTCAATCTT	0.512000													6	41					0	0	1	0	0
ZNF480	147657	broad.mit.edu	37	19	52825349	52825349	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52825349C>T	ENST00000595962.1	+	5	912	c.846C>T	c.(844-846)acC>acT	p.T282T	CTD-2525I3.6_ENST00000594379.1_RNA|ZNF480_ENST00000335090.6_Silent_p.T205T|ZNF480_ENST00000490272.1_3'UTR|ZNF480_ENST00000334564.7_Silent_p.T239T	NM_144684.2	NP_653285.2	Q8WV37	ZN480_HUMAN	zinc finger protein 480	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		GAATTCATACCAGAGAGAAGC	0.348000													14	44					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50223468	50223468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50223468C>T	ENST00000284509.6	-	16	1631	c.1490G>A	c.(1489-1491)gGg>gAg	p.G497E	ATP8B4_ENST00000559829.1_Missense_Mutation_p.G497E	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	497					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CACTAGAGCCCCTTCATCAGG	0.393000													11	49					0	0	1	0	0
DPPA3	359787	broad.mit.edu	37	12	7867834	7867834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7867834C>T	ENST00000345088.2	+	2	255	c.138C>T	c.(136-138)atC>atT	p.I46I		NM_199286.2	NP_954980.1	Q6W0C5	DPPA3_HUMAN	developmental pluripotency associated 3	46						cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)	8				Kidney(36;0.0887)		ACTTGACTATCAACGCTAGTA	0.458000													14	102					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142176561	142176561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142176561G>A	ENST00000350721.4	-	45	7661	c.7540C>T	c.(7540-7542)Cgc>Tgc	p.R2514C	ATR_ENST00000383101.3_Missense_Mutation_p.R2450C	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2514	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TGAGTCAGGCGAAATGGCACA	0.368000								Other conserved DNA damage response genes					28	63					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54780682	54780682	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54780682G>A	ENST00000391748.1	-	10	1586	c.1459C>T	c.(1459-1461)Cag>Tag	p.Q487*	LILRB2_ENST00000391746.1_Nonsense_Mutation_p.Q488*|LILRB2_ENST00000314446.5_Nonsense_Mutation_p.Q487*|LILRB2_ENST00000434421.1_Nonsense_Mutation_p.Q372*|LILRB2_ENST00000391749.4_Nonsense_Mutation_p.Q488*	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	488					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGTTTGCCCTGACGTCGATGT	0.607000													33	175					0	0	1	0	0
ANKRD22	118932	broad.mit.edu	37	10	90588376	90588376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90588376G>A	ENST00000371930.4	-	3	471	c.261C>T	c.(259-261)ttC>ttT	p.F87F		NM_144590.2	NP_653191.2	Q5VYY1	ANR22_HUMAN	ankyrin repeat domain 22	87										NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10		Colorectal(252;0.0163)		Colorectal(12;6.29e-05)|COAD - Colon adenocarcinoma(12;7.69e-05)		GATAATCAATGAAGGTAAATT	0.323000													50	120					0	0	1	0	0
SLAMF8	56833	broad.mit.edu	37	1	159799809	159799809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159799809G>A	ENST00000289707.5	+	2	343	c.194G>A	c.(193-195)cGa>cAa	p.R65Q	SLAMF8_ENST00000471286.1_3'UTR|SLAMF8_ENST00000368104.4_Intron	NM_020125.2	NP_064510.1	Q9P0V8	SLAF8_HUMAN	SLAM family member 8	65						integral to membrane				endometrium(2)|large_intestine(4)|lung(6)	12	all_hematologic(112;0.0597)					ACGTTTTTCCGAGGCTCCCTG	0.637000													80	159					0	0	1	0	0
RNASE3	6037	broad.mit.edu	37	14	21359980	21359980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21359980G>A	ENST00000304639.3	+	2	193	c.135G>A	c.(133-135)ctG>ctA	p.L45L		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	45					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	ACATCAGTCTGAACCCCCCTC	0.488000													49	118					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569441	179569441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179569441C>T	ENST00000589042.1	-	105	29982	c.29758G>A	c.(29758-29760)Gaa>Aaa	p.E9920K	TTN_ENST00000342992.6_Missense_Mutation_p.E8676K|TTN_ENST00000591111.1_Missense_Mutation_p.E9603K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9603	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTCAATTTCAAAGACAGCA	0.328000													10	15					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331697	70331697	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70331697G>A	ENST00000338508.4	-	32	4703	c.4704C>T	c.(4702-4704)ctC>ctT	p.L1568L	SHANK2_ENST00000423696.2_Silent_p.L1188L|SHANK2_ENST00000409161.1_Silent_p.L971L|SHANK2_ENST00000449833.2_Silent_p.L972L			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1188					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTTCTTCCACGAGCGCGTCTT	0.552000													61	172					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699242	43699242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43699242G>A	ENST00000405312.3	-	4	1130	c.893C>T	c.(892-894)cCc>cTc	p.P298L	PSG4_ENST00000433626.2_Missense_Mutation_p.P205L|PSG4_ENST00000244295.9_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	298	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				CGTGACATTGGGTAGAATGAG	0.483000													68	274					0	0	1	0	0
FXYD5	53827	broad.mit.edu	37	19	35657304	35657304	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35657304G>A	ENST00000543307.1	+	8	643	c.563G>A	c.(562-564)gGt>gAt	p.G188D	FXYD5_ENST00000588699.1_Missense_Mutation_p.G188D|FXYD5_ENST00000541435.2_Intron|FXYD5_ENST00000423817.3_Intron|FXYD5_ENST00000392219.2_Intron|FXYD5_ENST00000342879.3_Intron|FXYD5_ENST00000392217.3_Intron|FXYD5_ENST00000591716.2_Intron|FXYD5_ENST00000590686.1_Intron			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	0					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GTTCTCAAAGGTCCCTGGGCA	0.453000													5	49					0	0	1	0	0
OGT	8473	broad.mit.edu	37	X	70764432	70764432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70764432C>T	ENST00000373719.3	+	4	695	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	OGT_ENST00000373701.3_Missense_Mutation_p.R150C|OGT_ENST00000498566.1_3'UTR	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	160					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					GTACTGTGTTCGCAGTGACCT	0.398000													3	15					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104129725	104129725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104129725C>T	ENST00000369983.3	+	26	3580	c.3320C>T	c.(3319-3321)gCc>gTc	p.A1107V		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1107					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AAGAGAGTGGCCTTAGAGTGT	0.483000													27	58					0	0	1	0	0
USB1	79650	broad.mit.edu	37	16	58044008	58044008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58044008C>T	ENST00000219281.3	+	3	552	c.441C>T	c.(439-441)tcC>tcT	p.S147S	USB1_ENST00000563149.1_Silent_p.S147S|USB1_ENST00000423271.3_Silent_p.S147S|USB1_ENST00000561743.1_Silent_p.S96S|USB1_ENST00000565662.1_3'UTR|USB1_ENST00000539737.2_Silent_p.S147S	NM_024598.3	NP_078874.2			U6 snRNA biogenesis 1																		GTATGACCTCCTTCCACAGGT	0.597000													6	48					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70500891	70500891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70500891C>T	ENST00000428974.2	+	5	525	c.467C>T	c.(466-468)tCg>tTg	p.S156L	FUK_ENST00000571514.1_Intron|FUK_ENST00000288078.6_Intron|FUK_ENST00000378912.2_Intron			Q8N0W3	FUK_HUMAN	fucokinase	612						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				TGCCTTCCTTCGTCACAGCCA	0.637000													10	30					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12661513	12661513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12661513G>A	ENST00000425538.1	+	12	2514	c.2314G>A	c.(2314-2316)Gaa>Aaa	p.E772K	MYOCD_ENST00000395988.1_Missense_Mutation_p.E676K|MYOCD_ENST00000343344.4_Missense_Mutation_p.E724K	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	724					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCCATCCTATGAAGATGCCGT	0.393000													21	36					0	0	1	0	0
CH25H	9023	broad.mit.edu	37	10	90966983	90966983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90966983G>A	ENST00000371852.2	-	1	88	c.67C>T	c.(67-69)Ctc>Ttc	p.L23F		NM_003956.3	NP_003947.1	O95992	CH25H_HUMAN	cholesterol 25-hydroxylase	23					bile acid biosynthetic process|fatty acid biosynthetic process|sterol biosynthetic process	cytosol|endoplasmic reticulum membrane|integral to membrane	cholesterol 25-hydroxylase activity|iron ion binding			kidney(1)|large_intestine(2)|lung(3)|stomach(1)	7		Colorectal(252;0.0161)		GBM - Glioblastoma multiforme(2;0.000133)		TGGTCCCAGAGGGGCTGCAGG	0.627000													6	6					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28861654	28861654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28861654C>T	ENST00000373833.6	+	8	819	c.534C>T	c.(532-534)gcC>gcT	p.A178A	RCC1_ENST00000429051.1_3'UTR|RCC1_ENST00000373831.3_Silent_p.A209A|RCC1_ENST00000373832.1_Silent_p.A178A|RCC1_ENST00000398958.2_Silent_p.A178A			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	178					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		TAAAGGTGGCCTCAGGTGGGT	0.577000													17	69					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105965741	105965741	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105965741C>T	ENST00000357060.3	-	7	1058	c.943G>A	c.(943-945)Ggc>Agc	p.G315S	WDR96_ENST00000428666.1_Missense_Mutation_p.G316S|WDR96_ENST00000278064.2_Missense_Mutation_p.G246S|WDR96_ENST00000369720.1_Missense_Mutation_p.G246S|WDR96_ENST00000369719.1_Missense_Mutation_p.G246S	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	315										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GCCAGCACGCCCTCCTTCTGA	0.338000													12	47					0	0	1	0	0
STOML1	9399	broad.mit.edu	37	15	74281509	74281509	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74281509G>A	ENST00000316900.5	-	3	454	c.330C>T	c.(328-330)ttC>ttT	p.F110F	STOML1_ENST00000359750.4_Silent_p.F110F|STOML1_ENST00000316911.6_Intron|STOML1_ENST00000541638.1_Silent_p.F68F|STOML1_ENST00000561656.1_Silent_p.F23F|STOML1_ENST00000564777.1_Intron	NM_001256672.1|NM_001256675.1|NM_001256677.1|NM_004809.4	NP_001243601.1|NP_001243604.1|NP_001243606.1|NP_004800.2	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	110						integral to membrane	sterol binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						AGGAGTCAATGAAGGGCAAGA	0.597000													25	57					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35144355	35144355	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:35144355C>T	ENST00000436258.1	-	0	1711																											ACGCTAACAACTGCAATGTGT	0.323000													9	34					0	0	1	0	0
MGEA5	10724	broad.mit.edu	37	10	103550824	103550824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103550824G>A	ENST00000361464.3	-	14	2678	c.2283C>T	c.(2281-2283)tcC>tcT	p.S761S	MGEA5_ENST00000482611.1_5'UTR|MGEA5_ENST00000357797.5_Silent_p.S694S|MGEA5_ENST00000439817.1_Silent_p.S708S	NM_012215.3	NP_036347.1	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	761	Histone acetyltransferase activity (By similarity).|Required for histone H4 binding (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	23		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		CCAGGCTGAGGGAAAGCAGCC	0.423000													37	73					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20999045	20999045	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20999045C>T	ENST00000261383.3	-	46	6851	c.6852G>A	c.(6850-6852)ggG>ggA	p.G2284G	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2284	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACAGCAGGACCCCTTGAATCA	0.453000													12	46					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20636757	20636757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20636757C>T	ENST00000219151.4	-	12	1678	c.468G>A	c.(466-468)ccG>ccA	p.P156P	ACSM1_ENST00000520010.1_Silent_p.P505P|ACSM1_ENST00000307493.4_Silent_p.P505P			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	505					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding	p.P505P(2)|p.P156P(2)		central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						CCCCTCGAATCGGGTCTGGGC	0.602000													19	16					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24880576	24880576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24880576G>A	ENST00000382554.3	+	6	2880	c.2562G>A	c.(2560-2562)acG>acA	p.T854T		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	854					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						ACTTTCTGACGAAGCTACACT	0.552000											OREG0022626	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	95	185					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890862	23890862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23890862C>T	ENST00000532292.1	-	1	313	c.219G>A	c.(217-219)gaG>gaA	p.E73E		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GTGTGGGCACCTCCGCTTGCG	0.682000													4	11					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349741	100349741	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100349741C>T	ENST00000542585.1	+	0	2161				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCACCACCTCCATGGAAGAGC	0.522000													25	69					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55449572	55449572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55449572C>T	ENST00000588756.1	-	7	2455	c.1969G>A	c.(1969-1971)Gat>Aat	p.D657N	NLRP7_ENST00000328092.5_Intron|NLRP7_ENST00000340844.2_Missense_Mutation_p.D657N|NLRP7_ENST00000448121.2_Intron|NLRP7_ENST00000590030.1_Missense_Mutation_p.D657N|NLRP7_ENST00000592784.1_Missense_Mutation_p.D657N|NLRP7_ENST00000446217.1_Missense_Mutation_p.D685N			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	657							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GAGCGAAGATCCTGCCGAGCC	0.502000													35	81					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	40068723	40068723	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40068723C>T	ENST00000350221.3	-	2	212	c.3G>A	c.(1-3)atG>atA	p.M1I	RP11-37C7.1_ENST00000558616.1_RNA	NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	1										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TTATAATATCCATTGAAATCC	0.338000													30	78					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3122903	3122903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3122903G>A	ENST00000263650.7	-	13	1611	c.1452C>T	c.(1450-1452)gcC>gcT	p.A484A	OSBPL5_ENST00000525498.1_Silent_p.A395A|OSBPL5_ENST00000389989.3_Silent_p.A416A|OSBPL5_ENST00000348039.5_Silent_p.A416A|OSBPL5_ENST00000542243.1_Silent_p.A115A	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	484					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TGACGTGGAAGGCAGACACGG	0.637000													17	41					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59728228	59728228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:59728228G>A	ENST00000361421.1	-	7	1281	c.1061C>T	c.(1060-1062)tCg>tTg	p.S354L		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	354						nucleus	DNA binding	p.S354L(2)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				CGACGGCTTCGAATTGATCAG	0.522000													14	52					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115391684	115391684	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115391684C>A	ENST00000369358.4	-	17	1916	c.1672G>T	c.(1672-1674)Gga>Tga	p.G558*	NRAP_ENST00000360478.3_Nonsense_Mutation_p.G523*|NRAP_ENST00000359988.3_Nonsense_Mutation_p.G558*|NRAP_ENST00000369360.3_Nonsense_Mutation_p.G523*			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	558						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ATCTCAAATCCTTTCCCCTTT	0.463000													48	147					1.46156e-29	1.47134e-29	1	1	0
CNGA2	1260	broad.mit.edu	37	X	150907031	150907031	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150907031G>A	ENST00000329903.4	+	1	109	c.76G>A	c.(76-78)Gcc>Acc	p.A26T		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	26					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCATCAAGGCCAATGGCAA	0.502000													43	33					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7416873	7416873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7416873C>T	ENST00000322644.6	+	29	5689	c.5290C>T	c.(5290-5292)Ccg>Tcg	p.P1764S		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1764	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				CAGCTACAGCCCGACATCACC	0.542000													121	205					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10951376	10951376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10951376G>A	ENST00000298232.7	-	9	649	c.282C>T	c.(280-282)gaC>gaT	p.D94D	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.D74D|TPTE_ENST00000361285.4_Silent_p.D112D	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	112					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAAAATTAGGTCGGCAAGGA	0.323000													20	197					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149509438	149509438	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149509438C>T	ENST00000261799.4	-	10	1930	c.1461G>A	c.(1459-1461)caG>caA	p.Q487Q		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	487	Ig-like C2-type 5.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCTCAAACTCCTGCTCCTCCT	0.647000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""						OREG0016927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	67					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48429349	48429349	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48429349C>T	ENST00000224605.2	-	2	802	c.537G>A	c.(535-537)caG>caA	p.Q179Q		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	179					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						TGGCCGTGTTCTGCGAGAGGC	0.721000													4	28					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41758873	41758873	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41758873G>A	ENST00000301178.4	+	16	2116		c.e16+1		AXL_ENST00000359092.3_Splice_Site|AXL_ENST00000593513.1_Splice_Site	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase							integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						CCAGCCAGTGGTAAGGGGCGT	0.517000													16	65					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234750088	234750088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234750088G>A	ENST00000411486.2	-	8	1403	c.1338C>T	c.(1336-1338)tgC>tgT	p.C446C	HJURP_ENST00000432087.1_Silent_p.C392C|HJURP_ENST00000441687.1_Silent_p.C361C	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	446					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		TGGGACTCAGGCAATATTCCC	0.547000													33	112					0	0	1	0	0
GEM	2669	broad.mit.edu	37	8	95265325	95265325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:95265325C>T	ENST00000297596.2	-	3	611	c.347G>A	c.(346-348)cGa>cAa	p.R116Q	GEM_ENST00000396194.2_Missense_Mutation_p.R116Q	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	116					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			CATCAGGGTTCGTTCATATGT	0.413000													42	87					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96701966	96701966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96701966G>A	ENST00000260682.6	+	3	361	c.349G>A	c.(349-351)Gga>Aga	p.G117R	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	117					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TTTCAGCAATGGAAAGAAATG	0.522000													35	69					0	0	1	0	0
CEACAM16	388551	broad.mit.edu	37	19	45211365	45211365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45211365G>A	ENST00000587331.1	+	6	1388	c.1173G>A	c.(1171-1173)caG>caA	p.Q391Q	CEACAM16_ENST00000405314.2_Silent_p.Q391Q|CTB-171A8.1_ENST00000590796.1_RNA	NM_001039213.2	NP_001034302.2	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 16	391										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				TGTTGGTGCAGAAGCTGAACC	0.632000													10	10					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48465262	48465262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48465262G>A	ENST00000358536.4	-	3	1028	c.759C>T	c.(757-759)ctC>ctT	p.L253L	PLXNB1_ENST00000296440.6_Silent_p.L253L|PLXNB1_ENST00000358459.4_Silent_p.L253L|PLXNB1_ENST00000456774.1_Silent_p.L253L|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	253	Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTGGTCCCGGAGACACACTC	0.622000													17	82					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102851526	102851526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102851526G>A	ENST00000264257.2	+	11	1593	c.1467G>A	c.(1465-1467)gaG>gaA	p.E489E	IL1RL2_ENST00000441515.2_Silent_p.E371E|IL1RL2_ENST00000481806.1_3'UTR|IL1RL2_ENST00000539491.1_Silent_p.E489E	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	489	TIR.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						TTGAGCTGGAGAAAATCGAGG	0.512000													33	87					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83350314	83350314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83350314G>A	ENST00000261722.3	-	5	586	c.379C>T	c.(379-381)Cgt>Tgt	p.R127C	AP3B2_ENST00000535348.1_Missense_Mutation_p.R95C|AP3B2_ENST00000535359.1_Missense_Mutation_p.R127C|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	127					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			GCACTGGCACGAATCAGCTGG	0.572000													20	66					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11684402	11684402	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11684402C>T	ENST00000262442.3	+	39	7697	c.7629C>T	c.(7627-7629)ttC>ttT	p.F2543F	DNAH9_ENST00000454412.2_Silent_p.F2543F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2543	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCATCTATTTCATTGATGACA	0.557000													13	26					0	0	1	0	0
LINC00477	144360	broad.mit.edu	37	12	24736816	24736816	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:24736816G>A	ENST00000483544.1	-	0	286					NR_029451.2																						CCTAGGAAACGAAGTAAAAAG	0.527000													8	65					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	14018946	14018946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14018946G>A	ENST00000279593.3	-	2	406	c.197C>T	c.(196-198)cCc>cTc	p.P66L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	66					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTCCACCCGGGGTACCACGGA	0.557000													26	99					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8136997	8136997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8136997C>T	ENST00000600128.1	-	63	8437	c.8023G>A	c.(8023-8025)Gaa>Aaa	p.E2675K	FBN3_ENST00000601739.1_Missense_Mutation_p.E2675K|FBN3_ENST00000270509.2_Missense_Mutation_p.E2675K			Q75N90	FBN3_HUMAN	fibrillin 3	2675						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ATCTTGCATTCGTAGCAGGCT	0.662000													63	147					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117243236	117243236	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117243236G>A	ENST00000332958.2	+	13	1375	c.1359G>A	c.(1357-1359)aaG>aaA	p.K453K		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	453					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						AAGAACTGAAGGATCTCCTTA	0.353000													14	58					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167525034	167525034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167525034C>T	ENST00000519204.1	+	8	1470	c.1352C>T	c.(1351-1353)tCa>tTa	p.S451L	TENM2_ENST00000545108.1_Missense_Mutation_p.S572L|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000518659.1_Missense_Mutation_p.S572L|TENM2_ENST00000520394.1_Missense_Mutation_p.S340L|TENM2_ENST00000403607.2_Missense_Mutation_p.S405L					teneurin transmembrane protein 2																		TTTTCAGATTCAGTGCAGGAC	0.448000													6	21					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72723336	72723336	+	Missense_Mutation	SNP	G	G	A	rs140390474		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72723336G>A	ENST00000377182.4	+	3	975	c.358G>A	c.(358-360)Gaa>Aaa	p.E120K	MAMDC2-AS1_ENST00000591368.1_RNA|MAMDC2-AS1_ENST00000414515.3_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	120	MAM 1.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						GTCAGCTAAGGAACCTTCAGA	0.438000													18	54					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54956501	54956501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54956501C>T	ENST00000173898.7	+	12	3456	c.3344C>T	c.(3343-3345)aCc>aTc	p.T1115I	TRO_ENST00000375022.4_Intron|TRO_ENST00000375041.2_Missense_Mutation_p.T718I|TRO_ENST00000399736.1_Intron|TRO_ENST00000420798.2_Missense_Mutation_p.T646I|TRO_ENST00000319167.8_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	1115	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GCACTTAGTACCGCTGCTGAC	0.582000													33	13					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84526469	84526469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84526469C>T	ENST00000360700.4	+	10	2945	c.2059C>T	c.(2059-2061)Cat>Tat	p.H687Y	ZNF711_ENST00000373165.3_Missense_Mutation_p.H641Y|ZNF711_ENST00000276123.3_Missense_Mutation_p.H641Y|ZNF711_ENST00000395402.1_Missense_Mutation_p.H649Y|ZNF711_ENST00000542798.1_Missense_Mutation_p.H483Y			Q9Y462	ZN711_HUMAN	zinc finger protein 711	641					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TAGTGATATCCATAAGGGTAG	0.388000													17	14					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	123987692	123987692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123987692G>A	ENST00000360013.3	+	5	680	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	KALRN_ENST00000240874.3_Missense_Mutation_p.E185K|KALRN_ENST00000460856.1_Missense_Mutation_p.E185K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	185					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GGAGTGGATCGAACTGCGGCT	0.602000													18	48					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	825075	825075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:825075C>T	ENST00000293892.3	-	7	1496	c.1497G>A	c.(1495-1497)cgG>cgA	p.R499R	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	168					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CTCCAATGCACCGGGCCCATC	0.761000													6	18					0	0	1	0	0
ZC3H15	55854	broad.mit.edu	37	2	187370268	187370268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:187370268C>T	ENST00000337859.6	+	7	1035	c.808C>T	c.(808-810)Ctt>Ttt	p.L270F	ZC3H15_ENST00000544130.1_Missense_Mutation_p.L65F	NM_018471.2	NP_060941.2	Q8WU90	ZC3HF_HUMAN	zinc finger CCCH-type containing 15	270						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			GATTGATAAACTTGAACAAGA	0.393000													11	60					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2217878	2217878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2217878C>T	ENST00000398665.3	+	22	2688	c.2652C>T	c.(2650-2652)ccC>ccT	p.P884P		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	884						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGCATTCCCCTGGCCAGCG	0.687000													6	27					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232941806	232941806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:232941806G>A	ENST00000418460.1	+	1	1164	c.1037G>A	c.(1036-1038)gGa>gAa	p.G346E		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		ACAGGAGGAGGAGCGGAGGTC	0.632000													15	39					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158596730	158596730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158596730G>A	ENST00000368148.3	-	41	5912	c.5732C>T	c.(5731-5733)cCt>cTt	p.P1911L	SPTA1_ENST00000368147.3_Missense_Mutation_p.P1908L|SPTA1_ENST00000461624.1_5'UTR	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1911					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGCCAGAGAAGGGGTCTTTTC	0.428000													63	149					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178556956	178556956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178556956G>A	ENST00000251582.7	-	16	2535	c.2434C>T	c.(2434-2436)Ctc>Ttc	p.L812F		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	812	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GTGCCGTGGAGGGGGCCCATG	0.657000													22	55					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32260977	32260977	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32260977C>T	ENST00000375015.4	-	26	1670	c.1470G>A	c.(1468-1470)gaG>gaA	p.E490E	C6orf10_ENST00000447241.2_Silent_p.E491E|C6orf10_ENST00000527965.1_Silent_p.E475E|C6orf10_ENST00000533191.1_Silent_p.E489E|C6orf10_ENST00000375007.4_Silent_p.E489E|C6orf10_ENST00000442822.2_Intron			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	491	Lys-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						CCTCAAAACTCTCCTTCTTTT	0.373000													13	227					0	0	1	0	0
AGPAT2	10555	broad.mit.edu	37	9	139571924	139571924	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139571924G>A	ENST00000371696.2	-	2	332	c.267C>T	c.(265-267)gcC>gcT	p.A89A	AGPAT2_ENST00000538402.1_Silent_p.A89A|AGPAT2_ENST00000371694.3_Silent_p.A89A	NM_006412.3	NP_006403.2	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	89					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			endometrium(1)|large_intestine(1)|lung(2)|prostate(2)	6	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		CACAGGGACGGGCCTCCTGCA	0.652000													19	51					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30202214	30202214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30202214G>A	ENST00000397771.2	-	13	1328	c.1151C>T	c.(1150-1152)tCa>tTa	p.S384L	ASCC2_ENST00000542393.1_Missense_Mutation_p.S308L|ASCC2_ENST00000307790.3_Missense_Mutation_p.S384L|ASCC2_ENST00000478812.1_5'UTR			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			CAAGACTGATGAGGCCTGCTG	0.567000													26	60					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233150519	233150519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233150519G>A	ENST00000258229.8	-	28	5078	c.4844C>T	c.(4843-4845)tCa>tTa	p.S1615L	PCNXL2_ENST00000344698.2_Missense_Mutation_p.S267L	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1615						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CAGGGTCGTTGAAGGCTGAAA	0.502000													16	51					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63149733	63149733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63149733C>T	ENST00000279178.3	+	6	1306	c.1057C>T	c.(1057-1059)Ctc>Ttc	p.L353F	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	353					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						AAGGATCTCCCTCCTGTCCTT	0.403000													40	107					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394038	233394038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233394038C>T	ENST00000258229.8	-	5	1804	c.1570G>A	c.(1570-1572)Gaa>Aaa	p.E524K	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	524						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TGCCTCTTTTCATGGCTGGAC	0.502000													19	50					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227924928	227924928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227924928G>A	ENST00000396625.3	-	27	2295	c.2088C>T	c.(2086-2088)gcC>gcT	p.A696A	COL4A4_ENST00000329662.7_Silent_p.A696A	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	696	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCAGCCCAGGGGCACCTTGGG	0.428000													50	107					0	0	1	0	0
PLBD1	79887	broad.mit.edu	37	12	14706282	14706282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14706282C>T	ENST00000240617.5	-	2	832	c.180G>A	c.(178-180)atG>atA	p.M60I		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	60					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						CATTCTTGTCCATTACATTTT	0.448000													18	98					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018525	161018525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161018525C>T	ENST00000368013.3	-	12	2606	c.2286G>A	c.(2284-2286)caG>caA	p.Q762Q	ARHGAP30_ENST00000368016.3_Intron|ARHGAP30_ENST00000368015.1_Silent_p.Q585Q	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	762	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CAGCTTCTACCTGGGCTTCCT	0.488000													38	304					0	0	1	0	0
SHBG	6462	broad.mit.edu	37	17	7534655	7534655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7534655C>T	ENST00000380450.4	+	4	562	c.531C>T	c.(529-531)ttC>ttT	p.F177F	SHBG_ENST00000574539.1_Silent_p.F119F|SHBG_ENST00000576728.1_Intron|SHBG_ENST00000416273.3_Silent_p.F177F|SHBG_ENST00000570547.1_Silent_p.F119F|SHBG_ENST00000575314.1_Silent_p.F119F|SHBG_ENST00000572182.1_Intron|SHBG_ENST00000572262.1_Intron|SHBG_ENST00000441599.2_Silent_p.F177F|SHBG_ENST00000576478.1_Intron|SHBG_ENST00000575903.1_Silent_p.F177F|SHBG_ENST00000340624.5_Silent_p.F119F	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin	177	Laminin G-like 1.				hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	GGCTGCTCTTCCCCGCTTCCA	0.612000													8	15					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149227596	149227596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:149227596C>T	ENST00000407073.1	+	9	3081	c.2084C>T	c.(2083-2085)tCa>tTa	p.S695L	MBD5_ENST00000404807.1_Missense_Mutation_p.S695L	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	695						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GGTCAGGGTTCATTTCCCATC	0.468000													24	64					0	0	1	0	0
C2	717	broad.mit.edu	37	6	31902026	31902026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31902026G>A	ENST00000299367.5	+	6	1075	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	CFB_ENST00000456570.1_Intron|C2_ENST00000452323.2_Intron|C2_ENST00000442278.2_Missense_Mutation_p.E135K|C2_ENST00000469372.1_Intron|CFB_ENST00000477310.1_Intron|CFB_ENST00000556679.1_Intron|C2_ENST00000418949.2_Missense_Mutation_p.E267K	NM_000063.4	NP_000054.2			complement component 2											haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	27		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		GAGTGTGTCGGAAAATGACTT	0.532000													66	241					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167298029	167298029	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167298029G>A	ENST00000409855.1	-	14	2160	c.2034C>T	c.(2032-2034)ttC>ttT	p.F678F		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	678					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						ACACATTCAGGAAGGAGTGGA	0.463000													20	51					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89653337	89653337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89653337C>T	ENST00000264344.5	-	22	2866	c.2659G>A	c.(2659-2661)Ggg>Agg	p.G887R	FAM13A_ENST00000508369.1_Missense_Mutation_p.G561R|FAM13A_ENST00000513837.1_Missense_Mutation_p.G533R|FAM13A_ENST00000395002.2_Missense_Mutation_p.G533R|FAM13A_ENST00000503556.1_Missense_Mutation_p.G547R|FAM13A_ENST00000511976.1_Missense_Mutation_p.G473R	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	887					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TCTTCTGACCCCTCCTCTTCT	0.413000													30	60					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19758545	19758545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19758545G>A	ENST00000357324.6	-	20	2682	c.2656C>T	c.(2656-2658)Cct>Tct	p.P886S	ATP13A1_ENST00000291503.5_Missense_Mutation_p.P768S	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	886					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						ACCCGCTCAGGGGCATTGGCC	0.682000													4	6					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27683082	27683082	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27683082G>A	ENST00000374040.3	-	24	3759	c.3500_splice	c.e24+1	p.R1167_splice	MAP3K6_ENST00000357582.2_Splice_Site_p.R1175_splice|MAP3K6_ENST00000493901.1_Splice_Site_p.R1175_splice			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	1175					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GGGCTTTACCGATCAGTCTCT	0.642000													13	24					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211163161	211163161	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211163161C>T	ENST00000352451.3	-	3	434	c.287G>A	c.(286-288)gGa>gAa	p.G96E	MYL1_ENST00000341685.4_Missense_Mutation_p.G52E|MYL1_ENST00000496436.1_5'UTR	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	96					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GCTGGGGTTTCCCAGAACTTT	0.483000													39	129					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131924381	131924381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131924381C>T	ENST00000378823.3	+	8	1455	c.637C>T	c.(637-639)Cgt>Tgt	p.R213C	RAD50_ENST00000487596.1_3'UTR|RAD50_ENST00000265335.6_Missense_Mutation_p.R352C	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	352					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTTAAAAGGTCGTCTACAGCT	0.368000								Homologous recombination					33	25					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149506170	149506170	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149506170G>A	ENST00000261799.4	-	11	2056	c.1587C>T	c.(1585-1587)ccC>ccT	p.P529P		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	529					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCACCTTAAAGGGCAAGGCTG	0.562000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								5	38					0	0	1	0	0
KRTAP10-12	386685	broad.mit.edu	37	21	46117708	46117708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46117708C>T	ENST00000400365.3	+	1	622	c.592C>T	c.(592-594)Ctc>Ttc	p.L198F	TSPEAR_ENST00000323084.4_Intron	NM_198699.1	NP_941972.1	P60413	KR10C_HUMAN	keratin associated protein 10-12	198	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|lung(8)	9						CGTGTCCCTCCTCTGCCGCCC	0.701000													50	179					0	0	1	0	0
KLK13	26085	broad.mit.edu	37	19	51563821	51563821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51563821G>A	ENST00000595793.1	-	2	150	c.108C>T	c.(106-108)ctC>ctT	p.L36L	KLK13_ENST00000335422.3_Intron|KLK13_ENST00000595547.1_Silent_p.L36L|KLK13_ENST00000596955.1_Silent_p.L36L	NM_015596.1	NP_056411.1	Q9UKR3	KLK13_HUMAN	kallikrein-related peptidase 13	36	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|skin(1)	16		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		AGCCACCTGGGAGAAACCCAC	0.572000													53	89					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19766141	19766141	+	Silent	SNP	G	G	A	rs117174741	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19766141G>A	ENST00000357324.6	-	11	1544	c.1518C>T	c.(1516-1518)atC>atT	p.I506I	ATP13A1_ENST00000496082.1_5'UTR|ATP13A1_ENST00000291503.5_Silent_p.I388I	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	506					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						TGGCCAGGGCGATGAGGGAGG	0.627000													17	50					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109865299	109865299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109865299G>A	ENST00000310903.5	+	19	1915	c.1809G>A	c.(1807-1809)agG>agA	p.R603R	MYO1H_ENST00000431443.2_Silent_p.R613R			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						TCCTCATAAGGCATCAGATCA	0.463000													69	177					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58978287	58978287	+	Silent	SNP	C	C	T	rs144610063		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58978287C>T	ENST00000361050.3	-	1	2137	c.2052G>A	c.(2050-2052)aaG>aaA	p.K684K		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	684						integral to membrane		p.K684K(1)		NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GATATGCTTTCTTCTTGAACT	0.542000													28	84					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41558063	41558063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41558063C>T	ENST00000373060.1	+	12	1870	c.1412C>T	c.(1411-1413)aCc>aTc	p.T471I	FOXP4_ENST00000373063.3_Missense_Mutation_p.T458I|FOXP4_ENST00000373057.3_Missense_Mutation_p.T469I|FOXP4_ENST00000409208.1_Missense_Mutation_p.T459I|FOXP4_ENST00000307972.4_Missense_Mutation_p.T471I	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	471					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCCCCCTTCACCTACGCCTCC	0.647000													42	120					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17415923	17415923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17415923C>T	ENST00000302539.4	-	37	4563	c.4438G>A	c.(4438-4440)Gag>Aag	p.E1480K	ABCC8_ENST00000389817.3_Missense_Mutation_p.E1479K	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1479	ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTGAAATTCTCCCCGCCTTCT	0.562000													26	70					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990672	990672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:990672C>T	ENST00000190165.2	+	2	1124	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	362					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		AGCCCCCTTTCCCCCAGCCAC	0.587000													11	58					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135745671	135745671	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:135745671C>A	ENST00000375845.3	-	7	801	c.771G>T	c.(769-771)gaG>gaT	p.E257D	MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000358371.4_Missense_Mutation_p.E144D|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392915.1_Missense_Mutation_p.E274D	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		ATGGGCTGAGCTCATCAGATT	0.453000													37	90					4.92203e-23	4.95309e-23	1	1	0
SDPR	8436	broad.mit.edu	37	2	192701434	192701434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:192701434C>T	ENST00000304141.4	-	2	822	c.493G>A	c.(493-495)Gag>Aag	p.E165K		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	165						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCAGGGATCTCATTTTCCTCC	0.468000													16	19					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21991299	21991299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21991299C>T	ENST00000594012.1	-	7	2036	c.1522G>A	c.(1522-1524)Gaa>Aaa	p.E508K	ZNF43_ENST00000354959.4_Missense_Mutation_p.E514K|ZNF43_ENST00000595461.1_Missense_Mutation_p.E508K|ZNF43_ENST00000598381.1_Missense_Mutation_p.E508K	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TTGCCACATTCTTCACATTTG	0.373000													23	107					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64275924	64275924	+	Missense_Mutation	SNP	C	C	T	rs145891572	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:64275924C>T	ENST00000261891.3	-	2	127	c.122G>A	c.(121-123)cGg>cAg	p.R41Q	DAPK2_ENST00000558069.1_Missense_Mutation_p.R41Q|DAPK2_ENST00000558482.1_5'UTR|DAPK2_ENST00000457488.1_Missense_Mutation_p.R41Q			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	41	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		GCTCTTCTCCCGGCACTTCTT	0.597000													8	59					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	123989367	123989367	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123989367C>T	ENST00000456829.2	+	6	848	c.597C>T	c.(595-597)tgC>tgT	p.C199C	VWA5A_ENST00000392744.4_Silent_p.C215C|VWA5A_ENST00000361352.5_Silent_p.C199C|VWA5A_ENST00000360334.4_Silent_p.C199C|VWA5A_ENST00000392748.1_Silent_p.C199C|VWA5A_ENST00000449321.1_Silent_p.C199C	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	199										autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						AATCCAACTGCCCCTTGAGTC	0.498000													12	53					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26128028	26128028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:26128028G>A	ENST00000381655.2	+	12	1297	c.1155G>A	c.(1153-1155)gtG>gtA	p.V385V	ATP8A2_ENST00000255283.8_Silent_p.V345V	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	345					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TTGAGGTTGTGAAGTATACTC	0.383000													42	90					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30510707	30510707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30510707G>A	ENST00000356798.6	+	17	2222	c.2042G>A	c.(2041-2043)cGg>cAg	p.R681Q	ITGAL_ENST00000358164.5_Missense_Mutation_p.R598Q|ITGAL_ENST00000433423.2_Missense_Mutation_p.R77Q|RP11-297C4.1_ENST00000563751.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	681					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity	p.R681Q(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GATGGCCACCGGACCAGAAGA	0.542000													13	164					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559839	44559839	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44559839C>T	ENST00000332567.4	-	1	2149	c.1797G>A	c.(1795-1797)caG>caA	p.Q599Q	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	599	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTTTGTTTTCCTGTGGCTTTT	0.493000													45	106					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212638	26212638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:26212638C>T	ENST00000379034.1	+	2	824	c.675C>T	c.(673-675)gtC>gtT	p.V225V		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	225	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						TGAAGTGTGTCCGCAGAGAGT	0.478000													33	22					0	0	1	0	0
RIC3	79608	broad.mit.edu	37	11	8132554	8132554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8132554C>T	ENST00000396677.2	-	3	314	c.315G>A	c.(313-315)atG>atA	p.M105I	RIC3_ENST00000539720.1_Missense_Mutation_p.M218I|RIC3_ENST00000530060.1_5'UTR|RIC3_ENST00000425599.2_Missense_Mutation_p.M186I|RIC3_ENST00000343202.4_Missense_Mutation_p.M266I|RIC3_ENST00000335425.7_Missense_Mutation_p.M85I|RIC3_ENST00000309737.6_Missense_Mutation_p.M267I			Q7Z5B4	RIC3_HUMAN	RIC3 acetylcholine receptor chaperone	267						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		CCTCTTCTATCATTCCCATTC	0.448000													33	125					0	0	1	0	0
SV2C	22987	broad.mit.edu	37	5	75581606	75581606	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75581606G>A	ENST00000502798.2	+	6	1490	c.1047_splice	c.e6-1	p.V350_splice	RP11-466P24.6_ENST00000502589.1_RNA|SV2C_ENST00000322285.7_Splice_Site_p.V350_splice	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	350					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CATTTCTTAGGTTGGAAAACA	0.458000													23	56					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325003	150325003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150325003C>T	ENST00000328902.5	-	3	899	c.683G>A	c.(682-684)gGa>gAa	p.G228E	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	228							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTAATAATCTCCTTCGTTTTC	0.512000													71	175					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776016	5776016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5776016C>T	ENST00000317254.3	+	1	94	c.46C>T	c.(46-48)Ctg>Ttg	p.L16L	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TTCATTTATTCTGAATGGAGT	0.413000													27	59					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6498355	6498355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6498355G>A	ENST00000361413.3	-	16	2735	c.2377C>T	c.(2377-2379)Cgt>Tgt	p.R793C	KIAA0753_ENST00000575027.1_5'UTR|KIAA0753_ENST00000589033.1_Missense_Mutation_p.R249C|KIAA0753_ENST00000542606.1_Missense_Mutation_p.R494C|KIAA0753_ENST00000572370.1_Missense_Mutation_p.R494C	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	793						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		TATCTTTGACGAACAGACTCC	0.308000													31	28					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53857356	53857356	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53857356C>T	ENST00000315251.5	-	3	1117	c.680G>A	c.(679-681)tGg>tAg	p.W227*		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase	227					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	CATGTCCATCCAGCCGAAGCC	0.607000													7	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594547	179594547	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179594547C>T	ENST00000589042.1	-	63	18657	c.18433G>A	c.(18433-18435)Gaa>Aaa	p.E6145K	TTN_ENST00000342992.6_Missense_Mutation_p.E4901K|TTN_ENST00000591111.1_Missense_Mutation_p.E5828K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5828	Ig-like 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTTATTTCATTCCCGTCT	0.428000													35	53					0	0	1	0	0
ZNF618	114991	broad.mit.edu	37	9	116779058	116779058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116779058C>T	ENST00000288466.7	+	10	901	c.802C>T	c.(802-804)Ccc>Tcc	p.P268S	ZNF618_ENST00000374126.5_Missense_Mutation_p.P280S	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	360					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						CTTACACGCCCCCATCAGTGA	0.577000													8	14					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108776277	108776277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108776277C>T	ENST00000232603.5	-	13	1170	c.1088G>A	c.(1087-1089)cGa>cAa	p.R363Q	MORC1_ENST00000483760.1_Missense_Mutation_p.R363Q	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	363					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding	p.R363Q(1)		breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AGCTTGGCTTCGGTTTTCTAC	0.338000													22	102					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433147	140433147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140433147C>T	ENST00000306549.3	+	1	2169	c.2092C>T	c.(2092-2094)Ctt>Ttt	p.L698F		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		698					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTGGTCATCCTTTCCTTTCT	0.373000													51	174					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90427414	90427414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90427414C>T	ENST00000394375.3	+	4	337	c.224C>T	c.(223-225)cCt>cTt	p.P75L	LIPF_ENST00000238983.4_Missense_Mutation_p.P65L|LIPF_ENST00000355843.2_Missense_Mutation_p.P65L	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	65					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		AATAGAATTCCTTATGGGAAG	0.353000													26	133					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30672584	30672584	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30672584G>A	ENST00000376406.3	-	10	5023	c.4376C>T	c.(4375-4377)aCc>aTc	p.T1459I	MDC1_ENST00000376405.2_Missense_Mutation_p.T1195I|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1459	Interaction with the PRKDC complex.|Pro-rich.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						GTCTGTGGAGGTGGAAGGCTG	0.567000								Other conserved DNA damage response genes					129	188					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156277015	156277015	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156277015C>T	ENST00000311277.4	-	9	1406	c.1143G>A	c.(1141-1143)ttG>ttA	p.L381L	AC097467.2_ENST00000417474.1_RNA|AC097467.2_ENST00000601977.1_RNA|MAP9_ENST00000515654.1_Silent_p.L357L|AC097467.2_ENST00000593387.1_RNA|AC097467.2_ENST00000598252.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	381					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TAGATTTCTTCAAAAACTCAG	0.343000													14	30					0	0	1	0	0
CMPK2	129607	broad.mit.edu	37	2	6991667	6991667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:6991667C>T	ENST00000256722.5	-	4	1139	c.1140G>A	c.(1138-1140)gaG>gaA	p.E380E	CMPK2_ENST00000478738.1_5'UTR|CMPK2_ENST00000458098.1_Intron|CMPK2_ENST00000404168.1_Silent_p.E380E	NM_207315.3	NP_997198.2	Q5EBM0	CMPK2_HUMAN	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	380					dTDP biosynthetic process	mitochondrion	ATP binding|cytidylate kinase activity|thymidylate kinase activity|UMP kinase activity			large_intestine(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GCAACCTCTCCTCAGGACTCA	0.587000													23	78					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100508335	100508335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:100508335C>T	ENST00000471714.1	-	55	4132	c.4023G>A	c.(4021-4023)gtG>gtA	p.V1341V	ABI3BP_ENST00000383691.4_Silent_p.V618V|ABI3BP_ENST00000284322.5_Silent_p.V664V			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	664						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TTCTGGGCCTCACAGTAGTAT	0.423000													4	6					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123845774	123845774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123845774G>A	ENST00000369005.1	+	4	4099	c.3759G>A	c.(3757-3759)gtG>gtA	p.V1253V	TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Silent_p.V1253V|TACC2_ENST00000334433.3_Silent_p.V1253V|TACC2_ENST00000515273.1_Silent_p.V1253V|TACC2_ENST00000453444.2_Silent_p.V1253V	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1253						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACAGTGGAGTGAAAGCTGTTT	0.592000													17	141					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52420785	52420785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52420785C>T	ENST00000420323.2	+	56	9180	c.8919C>T	c.(8917-8919)acC>acT	p.T2973T		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2973	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGCCAGGCACCAAGGTGGATG	0.572000													4	6					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67132350	67132350	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67132350C>T	ENST00000284425.2	-	4	517	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	ABCA6_ENST00000590645.1_Missense_Mutation_p.E115K	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	115					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AGAAGTATTTCGTCCATGTGT	0.323000													4	11					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2298005	2298005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2298005C>T	ENST00000381458.5	+	7	920	c.857C>T	c.(856-858)tCt>tTt	p.S286F	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	286					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity	p.S286F(1)		breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	GCGCTGCGGTCTTTGGGGATT	0.582000													46	74					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20376776	20376776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20376776G>A	ENST00000302451.4	-	9	1451	c.1203C>T	c.(1201-1203)gtC>gtT	p.V401V		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	401	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						CTTTGTCAAAGACGACTACGT	0.438000													16	140					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047864	9047864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9047864G>A	ENST00000397910.4	-	5	33970	c.33767C>T	c.(33766-33768)tCc>tTc	p.S11256F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11258	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCACCAGTGGAGACAGTCAA	0.468000													3	22					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216680433	216680433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216680433C>T	ENST00000391890.3	-	9	1694	c.1177G>A	c.(1177-1179)Gaa>Aaa	p.E393K	ESRRG_ENST00000463665.1_Missense_Mutation_p.E347K|ESRRG_ENST00000366937.1_Missense_Mutation_p.E421K|ESRRG_ENST00000361395.2_Missense_Mutation_p.E386K|ESRRG_ENST00000360012.3_Missense_Mutation_p.E386K|ESRRG_ENST00000493603.1_Missense_Mutation_p.E386K|ESRRG_ENST00000366938.2_Missense_Mutation_p.E386K|ESRRG_ENST00000359162.2_Missense_Mutation_p.E386K|ESRRG_ENST00000366940.2_Missense_Mutation_p.E386K|ESRRG_ENST00000361525.3_Missense_Mutation_p.E386K|ESRRG_ENST00000493748.1_Missense_Mutation_p.E386K|ESRRG_ENST00000408911.3_Missense_Mutation_p.E409K|ESRRG_ENST00000487276.1_Missense_Mutation_p.E386K	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	409					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CGAGGGTCTTCCATGTGCTGG	0.507000													46	85					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145435641	145435641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145435641G>A	ENST00000511217.1	+	7	1472	c.1420G>A	c.(1420-1422)Ggt>Agt	p.G474S	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Missense_Mutation_p.G474S			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	474							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATTTCAGAAGGTGATCCACG	0.557000													66	182					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138768660	138768660	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138768660A>T	ENST00000242351.5	-	3	879	c.563T>A	c.(562-564)cTc>cAc	p.L188H	ZC3HAV1_ENST00000471652.1_Missense_Mutation_p.L188H|ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.L188H	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	188					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						ATGGGACCGGAGGCAGTTGGG	0.572000													16	50					0	0	1	0	0
MAGEH1	28986	broad.mit.edu	37	X	55479463	55479463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:55479463C>T	ENST00000342972.1	+	1	926	c.656C>T	c.(655-657)cCt>cTt	p.P219L		NM_014061.3	NP_054780.2	Q9H213	MAGH1_HUMAN	melanoma antigen family H, 1	219					apoptosis					central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|skin(2)	15						TATTCCGCCCCTTAAGTAGAT	0.493000													24	17					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3321352	3321352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3321352G>A	ENST00000378398.3	+	8	1019	c.937G>A	c.(937-939)Gac>Aac	p.D313N	PRDM16_ENST00000378391.2_Missense_Mutation_p.D312N|PRDM16_ENST00000442529.2_Missense_Mutation_p.D312N|PRDM16_ENST00000441472.2_Missense_Mutation_p.D312N|PRDM16_ENST00000514189.1_Missense_Mutation_p.D313N|PRDM16_ENST00000511072.1_Missense_Mutation_p.D313N|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Missense_Mutation_p.D312N			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	312					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GTACAAATGCGACCAGTGTCC	0.607000			T	EVI1	"""MDS, AML"""								28	48					0	0	1	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32918430	32918430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32918430G>A	ENST00000374843.4	-	2	324	c.239C>T	c.(238-240)cCt>cTt	p.P80L	XXbac-BPG181M17.5_ENST00000429234.1_Intron|HLA-DMA_ENST00000395303.3_Missense_Mutation_p.P80L|HLA-DMA_ENST00000395305.3_Intron|HLA-DMA_ENST00000464392.1_Intron	NM_006120.3	NP_006111.2	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM alpha	80						integral to membrane|MHC class II protein complex				kidney(1)|large_intestine(2)|lung(8)	11						GGGCAGGCGAGGCACCCGAGT	0.537000													25	110					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149323835	149323835	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149323835G>T	ENST00000255266.5	-	1	521	c.402C>A	c.(400-402)ttC>ttA	p.F134L		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	134	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGTCCAAAGGGAAGACGATCT	0.567000													37	109					6.53348e-20	6.57289e-20	1	1	0
GRAMD4	23151	broad.mit.edu	37	22	47022730	47022730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:47022730G>A	ENST00000406902.1	+	2	247	c.34G>A	c.(34-36)Ggt>Agt	p.G12S	GRAMD4_ENST00000361034.3_Missense_Mutation_p.G12S			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	12					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CAGGTTCAGAGGTCACAAGAG	0.562000													14	65					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41010033	41010033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41010033G>A	ENST00000352632.3	+	12	1745	c.1659G>A	c.(1657-1659)gaG>gaA	p.E553E	SPTBN4_ENST00000598249.1_Silent_p.E553E|SPTBN4_ENST00000595535.1_Silent_p.E553E|SPTBN4_ENST00000344104.3_Silent_p.E553E|SPTBN4_ENST00000338932.3_Silent_p.E553E			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	553					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGATGGAGGAGATGCAGGTGC	0.622000													7	39					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81053203	81053203	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81053203C>T	ENST00000334512.5	+	12	1595	c.1023C>T	c.(1021-1023)tcC>tcT	p.S341S	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	341	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GGCCTGCCTCCATGGGGGGCA	0.667000													30	156					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	176580	176580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:176580G>A	ENST00000538872.1	+	1	650	c.532G>A	c.(532-534)Ggc>Agc	p.G178S	IQSEC3_ENST00000326261.4_Missense_Mutation_p.G178S			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	178					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CCTCGGCAAGGGCGTCCTGAG	0.647000													5	31					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3721927	3721927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3721927G>A	ENST00000324932.7	-	24	4075	c.3655C>T	c.(3655-3657)Ctc>Ttc	p.L1219F	NUP98_ENST00000359171.4_Missense_Mutation_p.L1219F|NUP98_ENST00000355260.3_Missense_Mutation_p.L1219F	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1236					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		GGGACAATGAGAGGACACAGT	0.423000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								14	57					0	0	1	0	0
KIAA1430	57587	broad.mit.edu	37	4	186111405	186111405	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186111405C>T	ENST00000458385.2	-	2	1065	c.946G>A	c.(946-948)Gag>Aag	p.E316K	KIAA1430_ENST00000296775.6_Missense_Mutation_p.E316K|KIAA1430_ENST00000514798.1_Missense_Mutation_p.E316K	NM_020827.1	NP_065878.1	Q9P2B7	K1430_HUMAN	KIAA1430	316										endometrium(3)|kidney(2)|large_intestine(5)|upper_aerodigestive_tract(1)	11		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		ACATCAGGCTCATGTTTTTCT	0.348000													8	27					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321602	56321602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56321602G>A	ENST00000443188.1	-	5	1084	c.374C>T	c.(373-375)tCg>tTg	p.S125L	NLRP11_ENST00000589093.1_Missense_Mutation_p.S125L|NLRP11_ENST00000592953.1_Missense_Mutation_p.S26L|NLRP11_ENST00000360133.3_Missense_Mutation_p.S125L|NLRP11_ENST00000589824.2_Missense_Mutation_p.S125L	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	125							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CACATCTGACGAAACGTCACG	0.383000													23	46					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77425644	77425644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77425644G>A	ENST00000560626.2	-	6	4255	c.3780C>T	c.(3778-3780)ccC>ccT	p.P1260P	PEAK1_ENST00000312493.4_Silent_p.P1260P			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1260					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										GTCTGCAAGAGGGCCCACGCC	0.527000													49	135					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41839448	41839448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41839448G>A	ENST00000396930.3	-	5	1277	c.734C>T	c.(733-735)tCc>tTc	p.S245F	KAT6A_ENST00000265713.2_Missense_Mutation_p.S245F|KAT6A_ENST00000406337.1_Missense_Mutation_p.S245F|KAT6A_ENST00000485568.1_Missense_Mutation_p.S245F	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	245					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TAGTTCAGGGGAAAACTTTAA	0.413000													10	24					0	0	1	0	0
MOGAT2	80168	broad.mit.edu	37	11	75431059	75431059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75431059C>T	ENST00000198801.5	+	2	184	c.114C>T	c.(112-114)ttC>ttT	p.F38F	MOGAT2_ENST00000526712.1_5'UTR	NM_025098.2	NP_079374.2	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	38					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					CTGTGGGCTTCATAGCCCTCC	0.597000													80	177					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052501	15052501	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15052501C>T	ENST00000248072.3	+	1	201	c.201C>T	c.(199-201)tcC>tcT	p.S67S		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					CCAACCTGTCCTTTGCTGACA	0.483000													25	69					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21098223	21098223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21098223G>A	ENST00000261383.3	-	19	2823	c.2824C>T	c.(2824-2826)Ccc>Tcc	p.P942S	DNAH3_ENST00000415178.1_Missense_Mutation_p.P942S	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	942	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CTGAGGATGGGAATGTACTGC	0.512000													51	208					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51984482	51984482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51984482G>A	ENST00000220478.3	+	7	1220	c.817G>A	c.(817-819)Gaa>Aaa	p.E273K	SCG3_ENST00000542355.2_Missense_Mutation_p.E41K	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	273				EEL -> RDF (in Ref. 1; AAD44483).	platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		CAACTTTGAGGAACTCCAATA	0.383000													53	89					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21236075	21236075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21236075C>T	ENST00000233242.1	-	25	4300	c.4173G>A	c.(4171-4173)atG>atA	p.M1391I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1391					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGTCAGCCTTCATGTGGTAAC	0.532000													58	120					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96028737	96028737	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96028737G>A	ENST00000260766.3	+	17	4967	c.4333G>A	c.(4333-4335)Gat>Aat	p.D1445N	PLCE1_ENST00000371380.2_Missense_Mutation_p.D1445N|PLCE1_ENST00000371375.1_Missense_Mutation_p.D1137N|PLCE1_ENST00000371385.3_Missense_Mutation_p.D1137N	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1445	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GGACGGAGACGATGGGATGCC	0.453000													17	71					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154395381	154395381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154395381G>A	ENST00000435029.4	+	1	2122	c.1962G>A	c.(1960-1962)atG>atA	p.M654I		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	654					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGCGTCAAATGAAAGAGGATG	0.408000													39	147					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47842882	47842882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47842882G>A	ENST00000289672.2	-	53	7938	c.7888C>T	c.(7888-7890)Cct>Tct	p.P2630S	C7orf69_ENST00000418326.2_Intron|C7orf69_ENST00000258776.4_Intron	NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2630					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGAATGCCAGGAAGATAGACG	0.498000													32	46					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51255362	51255362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:51255362G>A	ENST00000404971.1	-	2	1389	c.50C>T	c.(49-51)tCg>tTg	p.S17L	NRXN1_ENST00000405581.1_Missense_Mutation_p.S17L|NRXN1_ENST00000402717.3_Missense_Mutation_p.S17L|NRXN1_ENST00000401669.2_Missense_Mutation_p.S17L|NRXN1_ENST00000406316.2_Missense_Mutation_p.S17L|NRXN1_ENST00000405472.3_Missense_Mutation_p.S17L|NRXN1_ENST00000406859.3_Missense_Mutation_p.S17L	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	17					adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAGCAGCAGCGAGAGGCACAG	0.716000													3	8					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176934326	176934326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176934326C>T	ENST00000367654.2	-	9	1608	c.1595G>A	c.(1594-1596)gGa>gAa	p.G532E	ASTN1_ENST00000424564.2_Missense_Mutation_p.G524E|ASTN1_ENST00000367657.3_Missense_Mutation_p.G524E|ASTN1_ENST00000361833.2_Missense_Mutation_p.G524E|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	532					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GGGCTGCTCTCCCAAAACCAG	0.418000													33	95					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142564239	142564239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142564239C>T	ENST00000392957.2	+	10	2250	c.1463C>T	c.(1462-1464)cCc>cTc	p.P488L	EPHB6_ENST00000442129.1_Missense_Mutation_p.P488L|EPHB6_ENST00000411471.2_Missense_Mutation_p.P211L	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	488	Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					ACTCTAGTGCCCTCTGCTGTC	0.597000													17	43					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45472166	45472166	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45472166C>T	ENST00000291574.4	+	4	466	c.291C>T	c.(289-291)acC>acT	p.T97T	TRAPPC10_ENST00000380221.3_Silent_p.T97T	NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	97					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						TTTAGGATACCGAAGTGTATA	0.398000													8	117					0	0	1	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401213	11401213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:11401213G>A	ENST00000002596.5	-	2	1591	c.417C>T	c.(415-417)tcC>tcT	p.S139S		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	139						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						GCAGCCGGATGGACGGGTTCA	0.587000													20	38					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142626122	142626122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142626122G>A	ENST00000265310.1	-	5	929	c.581C>T	c.(580-582)tCc>tTc	p.S194F	TRPV5_ENST00000442623.1_Missense_Mutation_p.S194F	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	194					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CTTACCCAGGGAGTCCTGGGC	0.612000													14	30					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50553013	50553013	+	Missense_Mutation	SNP	C	C	T	rs149927638	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50553013C>T	ENST00000262794.5	+	7	1171	c.1088C>T	c.(1087-1089)tCg>tTg	p.S363L	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000395858.3_Missense_Mutation_p.S363L|MOV10L1_ENST00000545383.1_Missense_Mutation_p.S363L|MOV10L1_ENST00000540615.1_Missense_Mutation_p.S343L	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	363					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TCTCAGATGTCGGAGAGCAGT	0.473000													16	65					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26868297	26868297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:26868297G>A	ENST00000381340.3	-	8	1206	c.790C>T	c.(790-792)Ctt>Ttt	p.L264F		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	264	MIR 3.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GTCGTACGAAGGAAAATGTGC	0.373000													28	133					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28710546	28710546	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28710546C>T	ENST00000257198.5	-	16	2877	c.2616G>A	c.(2614-2616)gaG>gaA	p.E872E	DSC1_ENST00000257197.3_3'UTR|RP11-408H20.2_ENST00000581836.1_RNA	NM_024421.2	NP_077739.1	Q08554	DSC1_HUMAN	desmocollin 1	872					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ACTCCAGTCCCTCTTCTTCCT	0.423000													40	196					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2464818	2464818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2464818G>A	ENST00000278772.4	-	6	1276	c.789C>T	c.(787-789)ctC>ctT	p.L263L	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						TCTTCCCTAAGAGGGTCCTCG	0.433000													18	99					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108377998	108377998	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:108377998G>A	ENST00000263054.6	-	21	2836	c.2829C>T	c.(2827-2829)ttC>ttT	p.F943F	SORCS1_ENST00000344440.6_Silent_p.F943F|SORCS1_ENST00000478809.2_5'UTR|SORCS1_ENST00000369698.1_Silent_p.F478F	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	943						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAGTAAATCTGAAGGATATGC	0.458000													18	64					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49657924	49657924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49657924C>T	ENST00000252825.4	-	1	757	c.571G>A	c.(571-573)Gaa>Aaa	p.E191K	HRC_ENST00000595625.1_Missense_Mutation_p.E191K	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	191	4 X tandem repeats, acidic.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		tcttcTCCTTCATCATCTTCC	0.567000													29	54					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41710035	41710035	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41710035G>A	ENST00000400454.1	-	8	2253	c.1776C>T	c.(1774-1776)acC>acT	p.T592T		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	592	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TACCTTTCACGGTCACGTGGA	0.507000													46	101					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94674868	94674868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94674868C>T	ENST00000260526.6	-	4	561	c.379G>A	c.(379-381)Gat>Aat	p.D127N	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.D127N	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	127					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TGGAAGAGATCGTTTTTGTTT	0.323000													13	47					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65260293	65260293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65260293G>A	ENST00000389722.3	-	13	2141	c.2088C>T	c.(2086-2088)atC>atT	p.I696I	SPTB_ENST00000556626.1_Silent_p.I696I|SPTB_ENST00000542895.1_Silent_p.I696I|SPTB_ENST00000389721.5_Silent_p.I696I|SPTB_ENST00000389720.3_Silent_p.I696I	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	696					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTCCTGGAAGATCTGCTCCA	0.587000													19	25					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103300777	103300777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103300777C>T	ENST00000233969.2	+	5	1549	c.1407C>T	c.(1405-1407)ttC>ttT	p.F469F		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	469						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						TTGTCATATTCTTTACTGTCT	0.403000													62	172					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3655083	3655083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3655083C>T	ENST00000263087.4	-	15	1852	c.1754G>A	c.(1753-1755)gGg>gAg	p.G585E		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	585					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACTGAGATCCCCCATAGCCGC	0.557000													25	50					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118020103	118020103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:118020103G>A	ENST00000425217.1	-	6	1200	c.1146C>T	c.(1144-1146)atC>atT	p.I382I	KSR2_ENST00000302438.5_Silent_p.I108I|KSR2_ENST00000339824.5_Silent_p.I411I|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	411					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCTGTGCTTGATGGAGTTGC	0.592000													12	68					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158368677	158368677	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158368677G>A	ENST00000334438.1	-	1	579	c.580C>T	c.(580-582)Cat>Tat	p.H194Y		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TCTTTCACATGGGTGTCAGTG	0.438000													15	43					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54785280	54785280	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54785280C>T	ENST00000218436.6	-	8	1256	c.1227G>A	c.(1225-1227)gtG>gtA	p.V409V		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	409	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TGGAGAGGATCACACTGGGGG	0.627000													15	14					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139601552	139601552	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139601552G>A	ENST00000303045.6	-	65	5271	c.4825C>T	c.(4825-4827)Cag>Tag	p.Q1609*	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Nonsense_Mutation_p.Q1589*	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1609					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TAGGCACACTGGGAAGGGTCA	0.602000										HNSCC(7;0.00092)			12	38					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98058822	98058822	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:98058822G>A	ENST00000370192.3	-	10	1180	c.1080C>T	c.(1078-1080)ttC>ttT	p.F360F		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	360					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGAAGACGATGAACACACGGC	0.458000													44	132					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49831696	49831696	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49831696G>A	ENST00000527477.1	+	0	1921																											AGAACTGTGAGCTTCGTTGAT	0.458000													55	103					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73491369	73491369	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73491369C>T	ENST00000314256.7	+	21	3127	c.2733C>T	c.(2731-2733)tcC>tcT	p.S911S	KIAA0195_ENST00000579208.1_Silent_p.S562S|KIAA0195_ENST00000375248.5_Silent_p.S921S	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	911					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCACAGTGTCCCGAGATGATG	0.592000													9	31					0	0	1	0	0
GIPR	2696	broad.mit.edu	37	19	46181175	46181175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46181175C>T	ENST00000590918.1	+	11	1035	c.936C>T	c.(934-936)ctC>ctT	p.L312L	GIPR_ENST00000593127.1_3'UTR|GIPR_ENST00000263281.3_Silent_p.L312L|GIPR_ENST00000304207.8_Silent_p.L276L	NM_000164.2	NP_000155.1	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	312					generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				endometrium(1)|kidney(2)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	12		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		TTAATTTCCTCATTTTTATCC	0.567000													22	81					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124359953	124359953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124359953C>T	ENST00000409039.3	+	46	7785	c.7760C>T	c.(7759-7761)tCg>tTg	p.S2587L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2587	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.S1179L(1)|p.S2587L(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGATTTATTTCGCTATTCAGT	0.443000													14	50					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181689429	181689429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181689429C>T	ENST00000526775.1	+	14	2004	c.1839C>T	c.(1837-1839)ttC>ttT	p.F613F	CACNA1E_ENST00000367570.1_Silent_p.F613F|CACNA1E_ENST00000367567.4_Silent_p.F220F|CACNA1E_ENST00000360108.3_Silent_p.F613F|CACNA1E_ENST00000357570.5_Silent_p.F564F|CACNA1E_ENST00000358338.5_Silent_p.F564F|CACNA1E_ENST00000367573.2_Silent_p.F613F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	613					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TCTTCCTCTTCATCGTTGTCT	0.473000													12	28					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767302	105767302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:105767302C>T	ENST00000374798.3	+	5	459	c.389C>T	c.(388-390)tCg>tTg	p.S130L	CYLC2_ENST00000487798.1_Missense_Mutation_p.S130L	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	130	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				ACAACAGATTCGGAATCAGAA	0.318000													17	38					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8928844	8928844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:8928844G>A	ENST00000256707.3	-	15	1901	c.1720C>T	c.(1720-1722)Ctc>Ttc	p.L574F	KIDINS220_ENST00000473731.1_Missense_Mutation_p.L574F|KIDINS220_ENST00000418530.1_Missense_Mutation_p.L532F|KIDINS220_ENST00000319688.5_Missense_Mutation_p.L575F|KIDINS220_ENST00000427284.1_Missense_Mutation_p.L574F	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	574	KAP NTPase.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AATTTAAGGAGGAGTTCCAAA	0.428000													35	98					0	0	1	0	0
KCNMB3	27094	broad.mit.edu	37	3	178968736	178968736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:178968736G>A	ENST00000392685.2	-	1	682	c.43C>T	c.(43-45)Ccc>Tcc	p.P15S	KCNMB3_ENST00000485523.1_Intron|KCNMB3_ENST00000497599.1_Intron|KCNMB3_ENST00000349697.2_Intron|KCNMB3_ENST00000314235.5_Intron	NM_171830.1	NP_741981.1	Q9NPA1	KCMB3_HUMAN	potassium large conductance calcium-activated channel, subfamily M beta member 3	0					detection of calcium ion|platelet activation|regulation of action potential in neuron	voltage-gated potassium channel complex	calcium-activated potassium channel activity|potassium channel regulator activity			NS(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_cancers(143;5.6e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;2.41e-27)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.03)			TGGGGAAAGGGAGAAGGAGAT	0.512000													11	82					0	0	1	0	0
ARL6IP5	10550	broad.mit.edu	37	3	69151000	69151000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:69151000C>T	ENST00000273258.3	+	2	291	c.187C>T	c.(187-189)Ccc>Tcc	p.P63S	ARL6IP5_ENST00000478935.1_Missense_Mutation_p.P63S	NM_006407.3	NP_006398.1	O75915	PRAF3_HUMAN	ADP-ribosylation-like factor 6 interacting protein 5	63					L-glutamate transport	endoplasmic reticulum membrane|integral to membrane				biliary_tract(1)|endometrium(1)|large_intestine(2)|ovary(1)|prostate(1)|urinary_tract(1)	7		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.78e-05)|Epithelial(33;0.000818)|LUSC - Lung squamous cell carcinoma(21;0.0118)|Lung(16;0.0189)|KIRC - Kidney renal clear cell carcinoma(39;0.203)|Kidney(39;0.238)		GTTTCTGAGTCCCTTCAACAT	0.453000													6	23					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121000554	121000554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121000554G>A	ENST00000392793.1	+	10	2846	c.2575G>A	c.(2575-2577)Gag>Aag	p.E859K	TECTA_ENST00000264037.2_Missense_Mutation_p.E859K			O75443	TECTA_HUMAN	tectorin alpha	859	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CGCCAGTGACGAGTTCTGTCT	0.537000													41	111					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161039388	161039388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161039388C>T	ENST00000368013.3	-	1	347	c.27G>A	c.(25-27)aaG>aaA	p.K9K	ARHGAP30_ENST00000368016.3_Silent_p.K9K|ARHGAP30_ENST00000368015.1_Intron	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	9					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CGCTGCCCTTCTTCTTTCCTT	0.622000													36	74					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42128555	42128555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42128555C>T	ENST00000401548.3	+	11	1319	c.1279C>T	c.(1279-1281)Cct>Tct	p.P427S	MEI1_ENST00000300398.4_5'UTR|MEI1_ENST00000540833.1_Missense_Mutation_p.P167S|MEI1_ENST00000400107.1_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	427							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						AGTTAGCAGCCCTGTGCTGGA	0.547000													27	37					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93902843	93902843	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:93902843G>A	ENST00000412050.4	-	6	1442	c.1354C>T	c.(1354-1356)Cct>Tct	p.P452S	CPEB3_ENST00000265997.4_Missense_Mutation_p.P466S	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	466	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				ACTACGAGAGGTCCAAACCTG	0.403000													22	57					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57399026	57399026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57399026C>T	ENST00000543257.1	-	11	1944	c.1378G>A	c.(1378-1380)Gga>Aga	p.G460R	C8B_ENST00000371237.4_Missense_Mutation_p.G512R|C8B_ENST00000535057.1_Missense_Mutation_p.G450R	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	512	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ACAGGGACTCCATTTCCTTGG	0.547000													33	64					0	0	1	0	0
KIAA0141	9812	broad.mit.edu	37	5	141309182	141309182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141309182C>T	ENST00000432126.2	+	5	582	c.448C>T	c.(448-450)Cca>Tca	p.P150S	KIAA0141_ENST00000194118.4_Missense_Mutation_p.P150S	NM_001142603.1|NM_014773.3	NP_001136075.1|NP_055588.3	Q14154	DELE_HUMAN	KIAA0141	150					apoptosis|regulation of caspase activity	mitochondrion	protein binding			endometrium(3)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(3)	16		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGATGGCCCAGCTCCCAG	0.602000													20	95					0	0	1	0	0
LMAN1	3998	broad.mit.edu	37	18	57013217	57013217	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:57013217G>A	ENST00000251047.5	-	8	1606	c.889C>T	c.(889-891)Caa>Taa	p.Q297*	LMAN1_ENST00000587940.1_5'UTR	NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1	297					blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	AATTCTTGTTGAAAGTGCTCA	0.418000													18	131					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54305645	54305645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54305645G>A	ENST00000545554.1	+	1	545	c.545G>A	c.(544-546)cGa>cAa	p.R182Q	UNC13C_ENST00000537900.1_Missense_Mutation_p.R182Q|UNC13C_ENST00000260323.11_Missense_Mutation_p.R182Q			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	182					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.R182Q(1)		breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGAGCTTTACGAAAACTGAGA	0.458000													39	98					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188592225	188592225	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:188592225C>T	ENST00000312675.4	+	11	2043	c.1797C>T	c.(1795-1797)gcC>gcT	p.A599A	LPP_ENST00000543006.1_Silent_p.A599A	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	599	LIM zinc-binding 3.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GCAACTCTGCCCGCATCAGGG	0.512000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								30	73					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29296383	29296383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29296383C>T	ENST00000331664.5	-	1	744	c.745G>A	c.(745-747)Gag>Aag	p.E249K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	249					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						GCCAGATCCTCCCTGACTTCC	0.552000													27	65					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080819	54080819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54080819C>T	ENST00000253144.9	+	7	2338	c.1005C>T	c.(1003-1005)gcC>gcT	p.A335A	ZNF331_ENST00000512387.1_Silent_p.A335A|ZNF331_ENST00000511593.2_Silent_p.A335A|ZNF331_ENST00000511154.1_Silent_p.A335A|ZNF331_ENST00000449416.1_Silent_p.A335A|ZNF331_ENST00000513265.1_3'UTR|ZNF331_ENST00000513999.1_Silent_p.A335A|ZNF331_ENST00000411977.2_Silent_p.A335A	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GTGGGAAGGCCTTTCGCTGGG	0.512000			T	?	follicular thyroid adenoma								19	53					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1243835	1243835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1243835G>A	ENST00000324642.3	+	9	1420	c.1297G>A	c.(1297-1299)Ggg>Agg	p.G433R	SLC6A18_ENST00000296821.4_Intron	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	433					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCTGGACGTGGGGGTCCTGCC	0.652000													8	52					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49292849	49292849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49292849G>A	ENST00000438782.1	+	7	795	c.559G>A	c.(559-561)Gac>Aac	p.D187N	CCDC36_ENST00000296449.5_Missense_Mutation_p.D187N|CCDC36_ENST00000452691.2_Missense_Mutation_p.D187N			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	187										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		GGCCCAGAATGACCTGGTGTT	0.453000													42	96					0	0	1	0	0
LGALS13	29124	broad.mit.edu	37	19	40097942	40097942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40097942G>A	ENST00000221797.4	+	4	428	c.383G>A	c.(382-384)aGa>aAa	p.R128K		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	128	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CAAGTGTCGAGAGATATCTCC	0.463000													10	97					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74825147	74825147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74825147G>A	ENST00000256362.4	+	2	1902	c.1661G>A	c.(1660-1662)gGc>gAc	p.G554D		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	554					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TGGCCCAGAGGCCTGTCCAAA	0.627000													37	100					0	0	1	0	0
PPM1M	132160	broad.mit.edu	37	3	52283280	52283280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52283280G>A	ENST00000296487.4	+	9	1098	c.694G>A	c.(694-696)Gag>Aag	p.E232K	PPM1M_ENST00000457351.2_Missense_Mutation_p.E393K|PPM1M_ENST00000409502.3_Missense_Mutation_p.E181K|PPM1M_ENST00000323588.4_Missense_Mutation_p.E232K			Q96MI6	PPM1M_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1M	232					protein dephosphorylation	nucleus	CTD phosphatase activity|manganese ion binding			prostate(1)|urinary_tract(1)	2				BRCA - Breast invasive adenocarcinoma(193;2.4e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)		ACTGTCCAACGAGCAGGTGGC	0.577000													5	22					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66075705	66075705	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:66075705C>T	ENST00000349533.6	+	13	2013	c.1828C>T	c.(1828-1830)Cag>Tag	p.Q610*	LEPR_ENST00000371058.1_Nonsense_Mutation_p.Q610*|LEPR_ENST00000371059.3_Nonsense_Mutation_p.Q610*|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371060.3_Nonsense_Mutation_p.Q610*|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000344610.8_Nonsense_Mutation_p.Q610*	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	610	Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CTATGCTGTTCAGGTGCGCTG	0.413000													72	174					0	0	1	0	0
MSI2	124540	broad.mit.edu	37	17	55704618	55704618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:55704618C>T	ENST00000284073.2	+	10	890	c.681C>T	c.(679-681)ggC>ggT	p.G227G	MSI2_ENST00000579180.1_Silent_p.G123G|MSI2_ENST00000442934.2_Silent_p.G166G|MSI2_ENST00000579505.1_3'UTR|MSI2_ENST00000416426.2_Silent_p.G205G|MSI2_ENST00000322684.3_Silent_p.G223G	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	227						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		CGACCTATGGCCGTGGCTACC	0.537000			T	HOXA9	CML								42	116					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51693482	51693482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51693482C>T	ENST00000267012.4	-	6	486	c.425G>A	c.(424-426)cGg>cAg	p.R142Q	BIN2_ENST00000544402.1_Missense_Mutation_p.R116Q|BIN2_ENST00000452142.2_Missense_Mutation_p.R110Q|BIN2_ENST00000604560.1_Missense_Mutation_p.R115Q	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	142	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						TTTCCGACCCCGCTTGGCAAT	0.498000													55	88					0	0	1	0	0
SEPN1	57190	broad.mit.edu	37	1	26138213	26138213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26138213C>T	ENST00000361547.2	+	9	1179	c.1124C>T	c.(1123-1125)cCc>cTc	p.P375L	SEPN1_ENST00000354177.4_Missense_Mutation_p.P341L|SEPN1_ENST00000374315.1_Missense_Mutation_p.P341L	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	375						endoplasmic reticulum membrane|extracellular region	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		CCCTCTGTGCCCTCCGTGATC	0.617000													4	7					0	0	1	0	0
RPL12P38	645688	broad.mit.edu	37	17	58511106	58511106	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58511106G>A	ENST00000588627.1	-	0	2251																											GCATTCCACAGCACCACTGTT	0.398000													13	43					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133306681	133306681	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:133306681G>A	ENST00000539605.1	-	10	8565	c.1881C>T	c.(1879-1881)gcC>gcT	p.A627A	ANKLE2_ENST00000357997.5_Silent_p.A689A|ANKLE2_ENST00000542657.1_Silent_p.A44A|ANKLE2_ENST00000542374.1_Intron|ANKLE2_ENST00000542282.1_Silent_p.A44A			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	689						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CTCCCGGCTCGGCGGCTTCTA	0.622000													12	97					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275789	130275789	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130275789G>A	ENST00000257359.6	-	9	3040	c.2334C>T	c.(2332-2334)agC>agT	p.S778S		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	778	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		AGGGCCGGAAGCTCTGCAGGC	0.582000													74	123					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2546536	2546536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2546536C>T	ENST00000567020.1	+	2	527	c.387C>T	c.(385-387)tcC>tcT	p.S129S	TBC1D24_ENST00000293970.5_Silent_p.S129S|RP11-20I23.1_ENST00000564543.1_Silent_p.S129S|TBC1D24_ENST00000434757.2_Silent_p.S129S	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	129	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						CCGACATCTCCTTCTGCCCCG	0.667000													21	45					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33612897	33612897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:33612897C>T	ENST00000321505.4	+	11	3970	c.3790C>T	c.(3790-3792)Cct>Tct	p.P1264S	KIAA1549L_ENST00000265654.5_Intron|KIAA1549L_ENST00000389726.3_Missense_Mutation_p.P1270S					KIAA1549-like																		TAGAGATGCTCCTCAGGAAAG	0.557000													5	46					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69433848	69433848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69433848C>T	ENST00000317746.2	-	1	397	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	119					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.E119K(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						TCAGAATATTCCCAACACAAT	0.294000													37	140					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031756	32031756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:32031756G>A	ENST00000360311.4	+	2	1734	c.1185G>A	c.(1183-1185)ggG>ggA	p.G395G		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G395G(2)		endometrium(3)|lung(4)|ovary(1)	8						ATGGTATAGGGAAACTTTATA	0.373000													18	78					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101567960	101567960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101567960C>T	ENST00000370449.4	+	13	1902	c.1789C>T	c.(1789-1791)Ccc>Tcc	p.P597S		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	597	ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GAGCATGCTTCCCATGATGAT	0.483000													58	161					0	0	1	0	0
GALNT11	63917	broad.mit.edu	37	7	151791331	151791331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151791331C>T	ENST00000434507.1	+	4	456	c.19C>T	c.(19-21)Cgg>Tgg	p.R7W	GALNT11_ENST00000482812.1_Intron|GALNT11_ENST00000422997.2_Missense_Mutation_p.R7W|GALNT11_ENST00000452146.2_Intron|GALNT11_ENST00000415421.1_Missense_Mutation_p.R7W|GALNT11_ENST00000320311.2_Missense_Mutation_p.R7W|GALNT11_ENST00000430044.2_Missense_Mutation_p.R7W			Q8NCW6	GLT11_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)	7						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|prostate(5)|skin(2)	27	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		TGTCACAGTTCGGTATTTCTG	0.368000													141	297					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307838	46307838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46307838G>A	ENST00000221538.3	-	3	1467	c.1325C>T	c.(1324-1326)cCc>cTc	p.P442L	RSPH6A_ENST00000597055.1_Missense_Mutation_p.P442L|RSPH6A_ENST00000600188.1_Missense_Mutation_p.P178L	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	442						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						AGTGACGTGGGGCAGCCGCGT	0.632000													18	66					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509295	71509295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71509295G>A	ENST00000396073.3	+	9	2433	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	718					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			TTATTACAGTGAATTTTACCC	0.388000													47	92					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55653197	55653197	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55653197A>T	ENST00000449290.2	+	2	385	c.293A>T	c.(292-294)gAg>gTg	p.E98V		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	98						intracellular	zinc ion binding										ATGCACAGAGAGACAAAGAAG	0.483000													10	33					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79030039	79030039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79030039C>T	ENST00000446378.2	+	2	5482	c.5451C>T	c.(5449-5451)ctC>ctT	p.L1817L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1817						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTTCTGACCTCCTTGTAGAAC	0.378000													20	69					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121383391	121383391	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121383391C>T	ENST00000297848.3	+	48	5582	c.5311_splice	c.e48-1	p.A1771_splice	COL14A1_ENST00000247781.3_Splice_Site_p.A1676_splice	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1771	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCCTCTTTAGCTCCCCATCCA	0.517000													18	211					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835304	38835304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38835304G>A	ENST00000449082.2	-	1	197	c.198C>T	c.(196-198)ttC>ttT	p.F66F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	66					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GCTCACCATAGAACTTGGGCA	0.542000													52	120					0	0	1	0	0
MRPL38	64978	broad.mit.edu	37	17	73900778	73900778	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73900778G>A	ENST00000309352.3	-	2	627	c.90C>T	c.(88-90)ccC>ccT	p.P30P	MRPL38_ENST00000585475.1_Intron|MRPL38_ENST00000409963.3_5'UTR|RP11-552F3.12_ENST00000587556.1_3'UTR	NM_032478.3	NP_115867.2	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38	30						actin cytoskeleton|mitochondrion|ribosome				ovary(1)|pancreas(1)|prostate(2)|skin(1)	5			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCCCAGCGGGGGTGTCCGGC	0.721000													5	11					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38876376	38876376	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38876376C>T	ENST00000274276.3	+	3	549	c.147C>T	c.(145-147)caC>caT	p.H49H	OSMR_ENST00000502536.1_Silent_p.H49H	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	49					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					AGAGTTTGCACTTACAATGGA	0.393000													18	83					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70681510	70681510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:70681510G>A	ENST00000377844.4	-	1	1081	c.322C>T	c.(322-324)Cct>Tct	p.P108S	ATXN8OS_ENST00000414504.2_RNA|KLHL1_ENST00000545028.1_5'UTR	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	108					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CCCTGCCCAGGAGCCCCTTGC	0.592000													27	45					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10798340	10798340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10798340C>T	ENST00000449870.1	+	18	2707	c.2390C>T	c.(2389-2391)cCc>cTc	p.P797L	ILF3_ENST00000588657.1_Missense_Mutation_p.P797L|ILF3_ENST00000590261.1_Missense_Mutation_p.P793L|ILF3_ENST00000318511.3_Missense_Mutation_p.P793L|ILF3_ENST00000586544.1_3'UTR	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	793	Interaction with PRMT1.|Poly-Gly.			G -> R (in Ref. 4; CAC01124 and 6; AAK07425).	M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			TACAACTCTCCCGGGGGCGGG	0.602000													14	44					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540351	169540351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169540351G>A	ENST00000340806.6	+	1	642	c.642G>A	c.(640-642)caG>caA	p.Q214Q		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	214										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						CGGGGCTGCAGAAGTTCTATA	0.532000													44	93					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29752501	29752501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29752501G>A	ENST00000357586.2	-	6	816	c.630C>T	c.(628-630)gcC>gcT	p.A210A	AP1B1_ENST00000317368.7_Silent_p.A210A|AP1B1_ENST00000402502.1_Silent_p.A210A|AP1B1_ENST00000432560.2_Silent_p.A210A|AP1B1_ENST00000405198.1_Silent_p.A210A|AP1B1_ENST00000356015.2_Silent_p.A210A|AP1B1_ENST00000415447.1_Silent_p.A210A	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	210					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						ACTCATTGAGGGCTGTCAGCA	0.602000													20	35					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	944731	944731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:944731C>T	ENST00000265846.5	-	5	686	c.467G>A	c.(466-468)cGa>cAa	p.R156Q	ADAP1_ENST00000539900.1_Missense_Mutation_p.R167Q|ADAP1_ENST00000449296.2_Missense_Mutation_p.R84Q|ADAP1_ENST00000463358.1_5'UTR	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	156	PH 1.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						AGCACCCTCTCGTTCTGTCAG	0.602000													32	54					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121290766	121290766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121290766G>A	ENST00000297848.3	+	28	3700	c.3430G>A	c.(3430-3432)Gga>Aga	p.G1144R	COL14A1_ENST00000309791.4_Missense_Mutation_p.G1144R|COL14A1_ENST00000247781.3_Missense_Mutation_p.G1049R	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1144	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TATAACTGATGGAAGATCACA	0.373000													20	46					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152520314	152520314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152520314C>T	ENST00000427231.2	-	45	5713	c.5511G>A	c.(5509-5511)ctG>ctA	p.L1837L	NEB_ENST00000604864.1_Silent_p.L1837L|NEB_ENST00000603639.1_Silent_p.L1837L|NEB_ENST00000172853.10_Silent_p.L1837L|NEB_ENST00000397345.3_Silent_p.L1837L|NEB_ENST00000409198.1_Silent_p.L1837L	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1837					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGTCATCTTCCAGGCTCCGGA	0.453000													22	70					0	0	1	0	0
IKZF5	64376	broad.mit.edu	37	10	124755623	124755623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124755623C>T	ENST00000368886.5	-	4	523	c.203G>A	c.(202-204)gGa>gAa	p.G68E	PSTK_ENST00000497219.1_Intron	NM_001271840.1	NP_001258769.1	Q9H5V7	IKZF5_HUMAN	IKAROS family zinc finger 5 (Pegasus)	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|lung(3)|prostate(1)	6		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		TACTAACATTCCTGAGTTTTC	0.423000													31	76					0	0	1	0	0
C15orf54	400360	broad.mit.edu	37	15	39544722	39544722	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:39544722G>A	ENST00000318578.3	+	2	754	c.386G>A	c.(385-387)tGg>tAg	p.W129*	RP11-624L4.1_ENST00000560484.1_RNA|RP11-624L4.1_ENST00000561058.1_RNA|RP11-624L4.1_ENST00000558209.1_RNA|C15orf54_ENST00000561223.1_Nonsense_Mutation_p.W129*	NM_207445.2	NP_997328.1	Q8N8G6	CO054_HUMAN	chromosome 15 open reading frame 54	129										NS(1)|haematopoietic_and_lymphoid_tissue(2)|lung(2)	5		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		TCTCCTGGGTGGAAGAACATG	0.468000													40	112					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110831353	110831353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110831353G>A	ENST00000375820.4	-	31	2496	c.2375C>T	c.(2374-2376)tCc>tTc	p.S792F		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	792	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGACCCCACGGAGCCTGGCAA	0.607000													3	11					0	0	1	0	0
FAM109A	144717	broad.mit.edu	37	12	111801115	111801115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111801115G>A	ENST00000450786.2	-	2	220	c.59C>T	c.(58-60)tCg>tTg	p.S20L	FAM109A_ENST00000392658.5_Silent_p.F39F|FAM109A_ENST00000547838.2_Silent_p.F39F|FAM109A_ENST00000361483.3_Silent_p.F52F|FAM109A_ENST00000548163.1_Silent_p.F39F			Q8N4B1	SESQ1_HUMAN	family with sequence similarity 109, member A	0	PH.				endosome organization|receptor recycling|retrograde transport, endosome to Golgi	clathrin-coated vesicle|early endosome|recycling endosome|trans-Golgi network	protein homodimerization activity			breast(1)|endometrium(1)|lung(1)|ovary(1)	4						CGCGCAGCACGAACCAGCGCC	0.662000													7	34					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21992598	21992598	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21992598G>A	ENST00000594012.1	-	7	737	c.223C>T	c.(223-225)Cat>Tat	p.H75Y	ZNF43_ENST00000354959.4_Missense_Mutation_p.H81Y|ZNF43_ENST00000595461.1_Missense_Mutation_p.H75Y|ZNF43_ENST00000598381.1_Missense_Mutation_p.H75Y	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	81	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TGGGTAAAATGAGAACACATA	0.294000													13	90					0	0	1	0	0
CAPS2	84698	broad.mit.edu	37	12	75683475	75683475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:75683475C>T	ENST00000393284.3	-	14	1283	c.682G>A	c.(682-684)Gaa>Aaa	p.E228K	CAPS2_ENST00000442339.2_Missense_Mutation_p.E50K|CAPS2_ENST00000409004.1_5'UTR|CAPS2_ENST00000409445.3_Missense_Mutation_p.E460K|RP11-560G2.1_ENST00000549953.1_RNA|CAPS2_ENST00000409799.1_Missense_Mutation_p.E378K			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	460							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						CCATTTCCTTCCTTGTCCAAC	0.348000													10	123					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216498859	216498859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216498859C>T	ENST00000366943.2	-	6	1317	c.931G>A	c.(931-933)Gtc>Atc	p.V311I	USH2A_ENST00000366942.3_Missense_Mutation_p.V311I|USH2A_ENST00000307340.3_Missense_Mutation_p.V311I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	311	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAAGGGTGGACCCGCGGGTGG	0.527000										HNSCC(13;0.011)			19	81					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553026	140553026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140553026G>A	ENST00000231137.3	+	1	784	c.610G>A	c.(610-612)Gag>Aag	p.E204K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		204	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGATCGGGAAGAGATACCAGA	0.507000													9	88					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677770	37677770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37677770G>A	ENST00000532828.2	-	5	920	c.669C>T	c.(667-669)ttC>ttT	p.F223F	ZNF585B_ENST00000312908.5_5'UTR|ZNF585B_ENST00000531805.1_Silent_p.F168F|CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000527838.1_3'UTR	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGTTATAAGGGAAACCTTTCC	0.388000													48	100					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50252883	50252883	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50252883G>A	ENST00000420502.1	+	0	518							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	AAGTCCTCAGGGGTCGTGGGT	0.582000													18	87					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77816807	77816807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77816807G>A	ENST00000334306.2	-	1	2195	c.2196C>T	c.(2194-2196)ttC>ttT	p.F732F		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	732																	GATAGACAGGGAAAATGGGCT	0.502000													105	229					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86200608	86200608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86200608G>A	ENST00000370571.2	-	59	5188	c.4822C>T	c.(4822-4824)Cat>Tat	p.H1608Y	COL24A1_ENST00000436319.1_Missense_Mutation_p.H1587Y	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1608	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTCAGTAAATGAAGGAAGTTC	0.428000													10	75					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30681077	30681077	+	Silent	SNP	G	G	A	rs144222920	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30681077G>A	ENST00000376406.3	-	5	1289	c.642C>T	c.(640-642)ttC>ttT	p.F214F	MDC1_ENST00000376405.2_Silent_p.F214F	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	214	Interaction with the MRN complex.|Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TGTTCAAATTGAAGGCAAAAG	0.527000								Other conserved DNA damage response genes					18	99					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220504278	220504278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220504278C>T	ENST00000358055.3	+	20	3610	c.3098C>T	c.(3097-3099)tCc>tTc	p.S1033F	SLC4A3_ENST00000373762.3_Missense_Mutation_p.S1060F|SLC4A3_ENST00000273063.6_Missense_Mutation_p.S1060F|SLC4A3_ENST00000373760.2_Missense_Mutation_p.S1033F|SLC4A3_ENST00000317151.3_Missense_Mutation_p.S1033F			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1033	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCATTGGCTCCCTGGGGGGG	0.652000													31	81					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54307109	54307109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54307109C>T	ENST00000545554.1	+	1	2009	c.2009C>T	c.(2008-2010)tCa>tTa	p.S670L	UNC13C_ENST00000537900.1_Missense_Mutation_p.S670L|UNC13C_ENST00000260323.11_Missense_Mutation_p.S670L			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	670					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGCTTGGATTCATCCACCCAG	0.413000													30	69					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177142399	177142399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:177142399C>T	ENST00000296525.3	-	5	690	c.577G>A	c.(577-579)Gat>Aat	p.D193N	ASB5_ENST00000512254.1_Missense_Mutation_p.D140N	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	193					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TGGTCAACATCTATGCCCCAG	0.443000													11	108					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61778959	61778959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:61778959C>T	ENST00000325324.6	+	10	1029	c.860C>T	c.(859-861)tCa>tTa	p.S287L	KIF2A_ENST00000509663.2_Intron|IPO11_ENST00000409296.3_Missense_Mutation_p.S327L	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	287						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		CATCCTTTTTCATTTACTCCT	0.308000													33	48					0	0	1	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103599776	103599776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103599776G>A	ENST00000560869.1	+	10	2262	c.1623G>A	c.(1621-1623)aaG>aaA	p.K541K	TNFAIP2_ENST00000538222.1_Silent_p.K24K|TNFAIP2_ENST00000451723.2_Silent_p.K210K|TNFAIP2_ENST00000333007.1_Silent_p.K541K			Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	541					angiogenesis|cell differentiation	extracellular space				NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	11		Melanoma(154;0.155)	Epithelial(46;0.191)			TGGTCCTCAAGACGGCCGAGC	0.632000													24	70					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042709	74042709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74042709C>T	ENST00000409561.1	+	3	1480	c.1359C>T	c.(1357-1359)ctC>ctT	p.L453L		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	453										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						ATACTTACCTCCCCCCGATCT	0.463000													17	22					0	0	1	0	0
GPR183	1880	broad.mit.edu	37	13	99947438	99947438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:99947438C>T	ENST00000376414.4	-	2	1045	c.962G>A	c.(961-963)aGg>aAg	p.R321K	UBAC2_ENST00000376440.2_Intron|UBAC2_ENST00000403766.3_Intron	NM_004951.4	NP_004942.1	P32249	GP183_HUMAN	G protein-coupled receptor 183	321					humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	23						TTTCAGCATCCTCATAACCTT	0.403000													15	94					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9337875	9337875	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:9337875G>A	ENST00000382496.5	-	4	839	c.174C>T	c.(172-174)ttC>ttT	p.F58F		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	58	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TTAACTGCGAGAAATCCACAG	0.343000													26	93					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228673	142228673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142228673G>A	ENST00000519067.1	-	4	1216	c.913C>T	c.(913-915)Ctg>Ttg	p.L305L	SLC45A4_ENST00000024061.3_Silent_p.L305L|SLC45A4_ENST00000433583.2_Silent_p.L298L|SLC45A4_ENST00000517878.1_Silent_p.L356L			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	356					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			AGGCGGGGCAGCTTGGTCTTG	0.617000													15	55					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	938710	938710	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:938710C>T	ENST00000265846.5	-	10	1275	c.1056G>A	c.(1054-1056)caG>caA	p.Q352Q	ADAP1_ENST00000539900.1_Silent_p.Q363Q|ADAP1_ENST00000449296.2_Silent_p.Q280Q	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	352	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						CCACCGCCTTCTGGAAGGCCG	0.687000													18	54					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	938749	938749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:938749C>T	ENST00000265846.5	-	10	1236	c.1017G>A	c.(1015-1017)gaG>gaA	p.E339E	ADAP1_ENST00000539900.1_Silent_p.E350E|ADAP1_ENST00000449296.2_Silent_p.E267E	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	339	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						CGGACTCCGTCTCGCAGGCAA	0.687000													17	59					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659215	196659215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196659215C>T	ENST00000312428.6	-	57	10663	c.10563G>A	c.(10561-10563)acG>acA	p.T3521T	DNAH7_ENST00000409063.1_Silent_p.T4T	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3521	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATGGGTAACTCGTTAGCCACA	0.383000													35	86					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33879667	33879667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33879667C>T	ENST00000374408.3	-	1	537	c.441G>A	c.(439-441)gtG>gtA	p.V147V		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	147										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGAAGTGGACCACAGCCTGGG	0.612000													43	99					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117885049	117885049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:117885049C>T	ENST00000439649.3	-	5	805	c.438G>A	c.(436-438)ggG>ggA	p.G146G	GFRA1_ENST00000355422.6_Silent_p.G151G|GFRA1_ENST00000544592.1_Silent_p.G30G|GFRA1_ENST00000369236.1_Silent_p.G146G	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	151					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		GGCAGTTGTTCCCTTTGGGAA	0.537000													6	14					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156658	22156658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22156658C>T	ENST00000397126.4	-	4	1326	c.1178G>A	c.(1177-1179)gGa>gAa	p.G393E	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGGTTTCTCTCCAGTATGAAT	0.383000													7	77					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11236895	11236895	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:11236895G>A	ENST00000304623.8	-	10	1858	c.1669C>T	c.(1669-1671)Cag>Tag	p.Q557*	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Nonsense_Mutation_p.Q220*|CTNND2_ENST00000511377.1_Nonsense_Mutation_p.Q466*|CTNND2_ENST00000458100.2_Nonsense_Mutation_p.Q124*|CTNND2_ENST00000359640.2_Nonsense_Mutation_p.Q557*	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	557					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding	p.Q557K(1)|p.Q557E(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGCAACATCTGAATCACTTCC	0.483000													39	89					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52962009	52962009	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52962009C>T	ENST00000549343.1	-	8	1379	c.1341G>A	c.(1339-1341)ctG>ctA	p.L447L	KRT74_ENST00000305620.2_Silent_p.L433L			Q7RTS7	K2C74_HUMAN	keratin 74	433	Coil 2.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		TGTCCAGGGCCAGTTTCAGGC	0.647000													35	76					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50144128	50144128	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:50144128C>T	ENST00000376025.2	-	0	1377							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					CTCCTACAGTCATCATGCACC	0.458000													3	2					0	0	1	0	0
SPACA3	124912	broad.mit.edu	37	17	31324017	31324017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:31324017C>T	ENST00000580599.1	+	4	702	c.293C>T	c.(292-294)tCa>tTa	p.S98L	SPACA3_ENST00000394638.1_Missense_Mutation_p.S64L|SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000269053.3_Missense_Mutation_p.S167L			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	167					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			ATGTACTGCTCAGGTAGCTGG	0.592000													28	44					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9046907	9046907	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9046907G>A	ENST00000397910.4	-	5	34927	c.34724C>T	c.(34723-34725)gCc>gTc	p.A11575V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11577	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGCCACGTGGCTGTAGTCTC	0.517000													8	22					0	0	1	0	0
NMNAT1	64802	broad.mit.edu	37	1	10042714	10042714	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10042714C>T	ENST00000377205.1	+	5	939	c.795C>T	c.(793-795)gtC>gtT	p.V265V		NM_022787.3	NP_073624.2	Q9HAN9	NMNA1_HUMAN	nicotinamide nucleotide adenylyltransferase 1	265					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding			large_intestine(2)|lung(2)|stomach(1)	5		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		ATGCTGGGGTCATCCTGGCCC	0.453000													23	37					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027662	37027662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37027662G>A	ENST00000358047.3	+	1	1231	c.1179G>A	c.(1177-1179)gaG>gaA	p.E393E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	393										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCCGCCCAGAGACCCCCAAGA	0.607000													41	34					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167798579	167798579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167798579G>A	ENST00000367848.1	-	26	3897	c.3400C>T	c.(3400-3402)Cac>Tac	p.H1134Y	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Missense_Mutation_p.H1226Y|ADCY10_ENST00000545172.1_Missense_Mutation_p.H1073Y			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1226					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TACTTGCAGTGAAAAAGATAA	0.433000													30	110					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147203	26147203	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:26147203C>T	ENST00000331351.5	+	2	1397	c.1005C>T	c.(1003-1005)atC>atT	p.I335I	HS3ST4_ENST00000475436.1_3'UTR	NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	335					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		GAATAGGGATCTATGCGCTGC	0.552000													80	166					0	0	1	0	0
LOC644669	644669	broad.mit.edu	37	18	15323268	15323268	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:15323268C>T	ENST00000455308.2	-	0	580					NR_027417.1																						TTAAACTTATCAACTGCAATT	0.299000													4	23					0	0	1	0	0
TRAPPC3	27095	broad.mit.edu	37	1	36605347	36605347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36605347G>A	ENST00000373166.3	-	3	304	c.214C>T	c.(214-216)Cgg>Tgg	p.R72W	TRAPPC3_ENST00000373162.1_Missense_Mutation_p.R26W|TRAPPC3_ENST00000462715.1_5'UTR|TRAPPC3_ENST00000373159.1_Missense_Mutation_p.R72W|TRAPPC3_ENST00000373163.1_Missense_Mutation_p.R26W	NM_001270896.1|NM_014408.3	NP_001257825.1|NP_055223.1	O43617	TPPC3_HUMAN	trafficking protein particle complex 3	72						endoplasmic reticulum	guanylate cyclase activity|heme binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Myeloproliferative disorder(586;0.0393)				GCAGTTTCCCGAAAGTCATGG	0.488000													18	43					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42732372	42732372	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42732372C>T	ENST00000287777.4	+	5	1729	c.1629C>T	c.(1627-1629)ttC>ttT	p.F543F		NM_152393.2	NP_689606.2			kelch-like family member 40																		TCGAGGCCTTCCCACAGGAGC	0.622000													15	45					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99439351	99439351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99439351C>T	ENST00000397899.2	-	7	1716	c.1385G>A	c.(1384-1386)aGa>aAa	p.R462K		NM_207362.2	NP_997245.2			KIAA1211-like																		CTCCGCTTCTCTCTCGGGCTC	0.746000													11	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061005	9061005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9061005C>T	ENST00000397910.4	-	3	26644	c.26441G>A	c.(26440-26442)gGa>gAa	p.G8814E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8816	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGTGAGTTCCTGGCCAGGA	0.542000													37	89					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60562911	60562911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:60562911G>A	ENST00000373886.3	+	15	2094	c.2090G>A	c.(2089-2091)gGg>gAg	p.G697E	BICC1_ENST00000263103.1_Missense_Mutation_p.G323E	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	697					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						AAGGCTCCAGGGAGTGAGCGC	0.532000													11	63					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73677285	73677285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73677285G>A	ENST00000339764.1	+	5	1346	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K	RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000543947.1_5'UTR|DNAJB13_ENST00000537753.1_5'UTR	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	199					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					CTTTGAGAAGGAAGGGGACCA	0.562000													6	25					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65053926	65053926	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65053926C>T	ENST00000298705.1	+	10	822	c.726C>T	c.(724-726)ttC>ttT	p.F242F	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	242																	TTTATACTTTCTGTACATATG	0.388000													7	59					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25470566	25470566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:25470566G>A	ENST00000278886.6	-	12	1614	c.1541C>T	c.(1540-1542)tCg>tTg	p.S514L	NINL_ENST00000422516.1_Missense_Mutation_p.S514L	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	514					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						CAGCCTCTCCGAATCCGAAAG	0.577000													53	114					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95159188	95159188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95159188G>A	ENST00000371501.4	-	13	1304	c.1182C>T	c.(1180-1182)ctC>ctT	p.L394L	MYOF_ENST00000358334.5_Silent_p.L394L|MYOF_ENST00000359263.4_Silent_p.L394L|MYOF_ENST00000371489.1_Silent_p.L394L|MYOF_ENST00000371502.4_Silent_p.L394L			Q9NZM1	MYOF_HUMAN	myoferlin	394	C2 3.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AAGGATCCACGAGATTTTTCT	0.348000													19	36					0	0	1	0	0
RPS24	6229	broad.mit.edu	37	10	79795386	79795386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:79795386C>T	ENST00000440692.1	+	3	329	c.187C>T	c.(187-189)Cat>Tat	p.H63Y	RPS24_ENST00000360830.4_Missense_Mutation_p.H63Y|RPS24_ENST00000372360.3_Missense_Mutation_p.H63Y|RPS24_ENST00000435275.1_Missense_Mutation_p.H63Y|RPS24_ENST00000476545.1_3'UTR	NM_001142285.1	NP_001135757.1	P62847	RS24_HUMAN	ribosomal protein S24	63					endocrine pancreas development|erythrocyte homeostasis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	nucleotide binding|structural constituent of ribosome|translation initiation factor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(2)|skin(1)	5	all_cancers(46;0.0343)|all_epithelial(25;0.000959)|Breast(12;0.00113)|Prostate(51;0.0095)		Epithelial(14;0.00128)|OV - Ovarian serous cystadenocarcinoma(4;0.00248)|all cancers(16;0.00428)			ATTCAGAACTCATTTTGGTGG	0.433000													65	187					0	0	1	0	0
RIMKLA	284716	broad.mit.edu	37	1	42875687	42875687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42875687C>T	ENST00000431473.3	+	4	643	c.514C>T	c.(514-516)Cac>Tac	p.H172Y		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	172	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						AGATAAACATCACCTCTCTGA	0.498000													57	185					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15874796	15874796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15874796C>T	ENST00000375847.3	+	7	1060	c.896C>T	c.(895-897)tCa>tTa	p.S299L	DNAJC16_ENST00000375838.1_Missense_Mutation_p.S299L|DNAJC16_ENST00000375849.1_Missense_Mutation_p.S299L	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	299					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GATTATTTATCATTTGGATAT	0.383000													17	48					0	0	1	0	0
IGHV1-46	28465	broad.mit.edu	37	14	106967409	106967409	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106967409C>T	ENST00000390622.2	-	0	350																											AAAATCCCTTCCTCAGCCCTG	0.557000													23	69					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4234802	4234802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4234802G>A	ENST00000221847.5	+	4	571	c.518G>A	c.(517-519)gGa>gAa	p.G173E		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	173	Fibronectin type-III 2.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGCGTCAGGGAGCTGCGCGC	0.612000													52	134					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17629689	17629689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17629689G>A	ENST00000262077.2	-	18	2740	c.2741C>T	c.(2740-2742)cCt>cTt	p.P914L	NUP153_ENST00000537253.1_Missense_Mutation_p.P945L	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	914					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			AGTCTGAGAAGGCCCAGAAGA	0.413000													38	93					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118598527	118598527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:118598527C>T	ENST00000336338.5	-	19	2616	c.2551G>A	c.(2551-2553)Gaa>Aaa	p.E851K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	851						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCAACAAGTTCCAAATAATTC	0.318000													28	63					0	0	1	0	0
MARK4	57787	broad.mit.edu	37	19	45801462	45801462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45801462C>T	ENST00000300843.4	+	16	2236	c.1939C>T	c.(1939-1941)Ccc>Tcc	p.P647S	MARK4_ENST00000262891.4_Intron	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	311					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CGCCTCTCTGCCCCAGGGATC	0.617000													21	39					0	0	1	0	0
NMNAT3	349565	broad.mit.edu	37	3	139297788	139297788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:139297788C>T	ENST00000406164.1	-	4	671	c.108G>A	c.(106-108)caG>caA	p.Q36Q	NMNAT3_ENST00000296202.7_Silent_p.Q73Q|NMNAT3_ENST00000507242.1_5'UTR|NMNAT3_ENST00000413939.2_Intron|NMNAT3_ENST00000406824.1_5'UTR|NMNAT3_ENST00000339837.5_Silent_p.Q36Q|RP11-319G6.1_ENST00000381790.3_RNA|NMNAT3_ENST00000511444.1_Silent_p.Q36Q|NMNAT3_ENST00000512391.1_Silent_p.Q73Q|RP11-319G6.1_ENST00000515247.1_RNA			Q96T66	NMNA3_HUMAN	nicotinamide nucleotide adenylyltransferase 3	73					water-soluble vitamin metabolic process	cytosol|mitochondrion	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)	9						AGTCGGATGTCTGCAGGGCCA	0.572000													21	53					0	0	1	0	0
VSX2	338917	broad.mit.edu	37	14	74711968	74711968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74711968G>A	ENST00000261980.2	+	3	646	c.556G>A	c.(556-558)Gag>Aag	p.E186K		NM_182894.2	NP_878314.1	P58304	VSX2_HUMAN	visual system homeobox 2	186					multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00154)		CATGAAAACGGAGCTGCCGGA	0.577000													15	55					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74625024	74625024	+	Silent	SNP	C	C	T	rs149610315		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74625024C>T	ENST00000321288.5	+	18	2385	c.2385C>T	c.(2383-2385)ttC>ttT	p.F795F	CCDC33_ENST00000398814.3_Silent_p.F592F|CCDC33_ENST00000268082.4_Silent_p.F185F|CCDC33_ENST00000558821.1_Silent_p.F185F			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	795							protein binding	p.F592F(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CTCTAGGCTTCCCTATGCTCT	0.562000													44	148					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107360936	107360936	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107360936C>T	ENST00000374779.2	-	1	852	c.759G>A	c.(757-759)ggG>ggA	p.G253G		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						GGAAGATGGTCCCACAGAATG	0.428000													22	85					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38753876	38753876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38753876G>A	ENST00000449082.2	-	22	3864	c.3865C>T	c.(3865-3867)Ctc>Ttc	p.L1289F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1289					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAGAAGATGAGGCAGACGAGG	0.537000													32	122					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	54015097	54015097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54015097C>T	ENST00000396328.1	-	3	401	c.162G>A	c.(160-162)gcG>gcA	p.A54A	WDR72_ENST00000360509.5_Silent_p.A54A|WDR72_ENST00000559418.1_Silent_p.A54A|WDR72_ENST00000557913.1_Silent_p.A54A	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	54								p.A54A(1)		NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		GGAGTTCTTTCGCTGAAATCT	0.353000													16	136					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247039	164247039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164247039G>A	ENST00000296533.2	-	2	1199	c.668C>T	c.(667-669)cCa>cTa	p.P223L	NPY1R_ENST00000509586.1_5'UTR	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	223					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAAACAAAGTGGACCAAAATA	0.353000													7	34					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105421934	105421934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105421934C>T	ENST00000333244.5	-	5	471	c.352G>A	c.(352-354)Gag>Aag	p.E118K		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	118	PDZ.					nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCCTCCACCTCTGTCTTCAGC	0.587000													24	53					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124519294	124519294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:124519294C>T	ENST00000408936.3	+	4	547	c.365C>T	c.(364-366)tCc>tTc	p.S122F	DAB2IP_ENST00000487716.1_3'UTR|DAB2IP_ENST00000309989.1_5'UTR|DAB2IP_ENST00000259371.2_Missense_Mutation_p.S94F			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	122	PH.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						CACCCCAGGTCCCATCTGATG	0.667000													19	55					0	0	1	0	0
CHRNA7	1139	broad.mit.edu	37	15	32404046	32404046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:32404046C>T	ENST00000306901.3	+	4	393	c.296C>T	c.(295-297)aCt>aTt	p.T99I	CHRNA7_ENST00000455693.2_Intron|CHRNA7_ENST00000454250.3_Missense_Mutation_p.T128I	NM_000746.5	NP_000737.1	P36544	ACHA7_HUMAN	cholinergic receptor, nicotinic, alpha 7 (neuronal)	99					activation of MAPK activity|calcium ion transport|cellular calcium ion homeostasis|memory|negative regulation of tumor necrosis factor production|positive regulation of angiogenesis|positive regulation of cell proliferation|response to hypoxia|response to nicotine	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|beta-amyloid binding|chloride channel regulator activity|nicotinic acetylcholine-activated cation-selective channel activity|protein homodimerization activity|toxin binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(2)	12		all_lung(180;6.35e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)	Nicotine(DB00184)|Varenicline(DB01273)	GGGGTGAAGACTGTTCGTTTC	0.403000													49	127					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71479591	71479591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71479591G>A	ENST00000296755.7	+	3	606	c.308G>A	c.(307-309)cGa>cAa	p.R103Q		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	103						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTTCATCACCGAAGTGACGTT	0.493000													31	92					0	0	1	0	0
METTL8	79828	broad.mit.edu	37	2	172195966	172195966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:172195966G>A	ENST00000375258.3	-	4	549	c.334C>T	c.(334-336)Cct>Tct	p.P112S				B3KW44	B3KW44_HUMAN	methyltransferase like 8	112							methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						AGAATTTCAGGAAATTCCCTC	0.358000													47	101					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240417	3240417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3240417C>T	ENST00000217939.6	-	5	3463	c.3309G>A	c.(3307-3309)atG>atA	p.M1103I		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1103						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACATACTGCTCATTATACCCA	0.483000													27	15					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156128253	156128253	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156128253C>T	ENST00000368285.3	+	5	705	c.438C>T	c.(436-438)gcC>gcT	p.A146A	SEMA4A_ENST00000368284.1_Intron|SEMA4A_ENST00000355014.2_Silent_p.A146A|SEMA4A_ENST00000368286.2_Intron|SEMA4A_ENST00000368282.1_Silent_p.A146A|SEMA4A_ENST00000487358.1_3'UTR	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	146	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					GCACCTTCGCCTTCAGCCCTG	0.522000													18	197					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40853713	40853713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:40853713C>T	ENST00000255224.3	-	2	1049	c.681G>A	c.(679-681)ggG>ggA	p.G227G	SYT4_ENST00000586678.1_Intron|SYT4_ENST00000590752.1_Silent_p.G209G	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	227	C2 1.|Phospholipid binding (Probable).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						TGTAGGGTATCCCATAGAATG	0.398000													33	105					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42683154	42683154	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42683154G>A	ENST00000358131.5	+	5	1102	c.894G>A	c.(892-894)gaG>gaA	p.E298E	TOX2_ENST00000435864.2_Silent_p.E167E|TOX2_ENST00000341197.3_Silent_p.E289E|TOX2_ENST00000423191.1_Silent_p.E247E|TOX2_ENST00000372999.1_Silent_p.E247E	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCCTGGGAGAGGAACAGAAGC	0.572000													12	31					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73679447	73679447	+	Missense_Mutation	SNP	C	C	T	rs146910386	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73679447C>T	ENST00000339764.1	+	6	1415	c.664C>T	c.(664-666)Cgc>Tgc	p.R222C	RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000543947.1_Missense_Mutation_p.R47C|DNAJB13_ENST00000537753.1_Missense_Mutation_p.R47C	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	222					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					GCTACACCCTCGCTTCCGCAG	0.562000													27	43					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150835336	150835336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150835336C>T	ENST00000397238.2	+	12	1602	c.1602C>T	c.(1600-1602)tcC>tcT	p.S534S	AGAP3_ENST00000463381.1_Intron	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	498	PH.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						GCTCCTGCTCCGTTTCCAGCG	0.697000													8	14					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5841610	5841610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5841610C>T	ENST00000317037.2	+	1	67	c.45C>T	c.(43-45)atC>atT	p.I15I	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTCTTTATCTTGAATGGCG	0.507000													13	73					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30876227	30876227	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:30876227G>A	ENST00000251071.5	-	11	2759	c.2009C>T	c.(2008-2010)tCc>tTc	p.S670F	CAPRIN2_ENST00000308433.5_Missense_Mutation_p.S337F|CAPRIN2_ENST00000395805.2_Missense_Mutation_p.S670F|CAPRIN2_ENST00000298892.5_Missense_Mutation_p.S670F|CAPRIN2_ENST00000417045.1_Missense_Mutation_p.S670F	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	670					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					ACTTTGACTGGACAGATTTTG	0.358000													17	61					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111080842	111080842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111080842G>A	ENST00000360467.5	+	7	695	c.389G>A	c.(388-390)gGa>gAa	p.G130E		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	130					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGGCCCAGGGGAAGGCCGGGC	0.622000													18	83					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982475	36982475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36982475G>A	ENST00000274963.8	+	7	1048	c.877G>A	c.(877-879)Gag>Aag	p.E293K		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	293					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						AGCCATCACTGAGATGGTAAG	0.607000													15	29					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198950188	198950188	+	Silent	SNP	C	C	T	rs151231252		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:198950188C>T	ENST00000428675.1	+	2	2345	c.1947C>T	c.(1945-1947)atC>atT	p.I649I	PLCL1_ENST00000437704.2_Silent_p.I551I	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	649	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.I551I(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CCATGAGGATCGATTCCAGTA	0.423000													21	54					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25299361	25299361	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25299361C>T	ENST00000549804.2	+	0	98				SNORD116-2_ENST00000384274.1_RNA|SNHG14_ENST00000547292.1_RNA																							GTGCTTGGATCGATGATGAGT	0.493000													61	148					0	0	1	0	0
CERS5	91012	broad.mit.edu	37	12	50561058	50561058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50561058G>A	ENST00000317551.6	-	1	147	c.23C>T	c.(22-24)cCc>cTc	p.P8L	CERS5_ENST00000547852.1_5'UTR|CERS5_ENST00000422340.2_5'UTR	NM_147190.2	NP_671723.1	Q8N5B7	CERS5_HUMAN	ceramide synthase 5	8					ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CAAGCTTAGGGGTCCCTGCGC	0.697000													14	28					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401379	77401379	+	Missense_Mutation	SNP	C	C	T	rs146432168		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77401379C>T	ENST00000282849.5	-	4	1155	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	ADAMTS18_ENST00000567121.1_Intron	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	246					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTGCAACCTTCGATGGTGATA	0.483000													28	64					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73491370	73491370	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73491370C>T	ENST00000314256.7	+	21	3128	c.2734C>T	c.(2734-2736)Cga>Tga	p.R912*	KIAA0195_ENST00000579208.1_Nonsense_Mutation_p.R563*|KIAA0195_ENST00000375248.5_Nonsense_Mutation_p.R922*	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	912					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACAGTGTCCCGAGATGATGC	0.587000													9	31					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48220020	48220020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48220020G>A	ENST00000263277.3	+	2	402	c.151G>A	c.(151-153)Gag>Aag	p.E51K	EHD2_ENST00000538399.1_Intron|CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	51					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		GCCGGCCCTGGAGGACGCAGA	0.662000													11	25					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12576177	12576177	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12576177C>T	ENST00000397732.3	-	4	730	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K	ZNF709_ENST00000428311.1_Missense_Mutation_p.E187K|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						TGAGTTCTTTCATGTATTTGA	0.403000													36	98					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142480013	142480013	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142480013G>A	ENST00000603901.1	+	0	145					NR_001296.3																						CCACTTCTGCGGTGGCTCCCT	0.562000													18	218					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132560846	132560846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132560846C>T	ENST00000265342.7	-	10	1557	c.1308G>A	c.(1306-1308)aaG>aaA	p.K436K	FSTL4_ENST00000507112.1_5'UTR	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	436						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACTTACGGGTCTTTCTAGCTG	0.527000													30	64					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43576027	43576027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43576027C>T	ENST00000406487.1	-	4	887	c.789G>A	c.(787-789)gcG>gcA	p.A263A		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	263	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region		p.A263A(1)		central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GGTTAGAGTTCGCGAAGCAAG	0.443000													116	256					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89939773	89939773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89939773G>A	ENST00000405460.2	+	14	2803	c.2707G>A	c.(2707-2709)Gaa>Aaa	p.E903K		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	903					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GATGATAAATGAAAGCAAAGG	0.294000													6	20					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24789026	24789026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24789026G>A	ENST00000310677.4	-	22	2768	c.2655C>T	c.(2653-2655)ttC>ttT	p.F885F	ADCY4_ENST00000418030.2_Silent_p.F885F|ADCY4_ENST00000554068.2_Silent_p.F885F	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	885					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		ATTCAGAGTAGAACTCCTTGA	0.488000													21	53					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143020469	143020469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143020469G>A	ENST00000343257.2	+	6	851	c.764G>A	c.(763-765)gGg>gAg	p.G255E	CLCN1_ENST00000495612.1_Intron	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	255					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GTGTTCTGCGGGGTATATGAG	0.602000													25	66					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209807842	209807842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209807842G>A	ENST00000391911.1	-	5	903	c.514C>T	c.(514-516)Cgg>Tgg	p.R172W	LAMB3_ENST00000356082.4_Missense_Mutation_p.R172W|LAMB3_ENST00000367030.3_Missense_Mutation_p.R172W	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	172	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GACTGGCACCGAACATCCTGC	0.602000													34	83					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1670063	1670063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1670063C>T	ENST00000252804.4	-	10	1264	c.1214G>A	c.(1213-1215)gGg>gAg	p.G405E	PXDN_ENST00000483018.1_5'UTR	NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	405	Ig-like C2-type 2.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCCGCTGTCCCCCTGTACGAC	0.587000													9	36					0	0	1	0	0
TMEM44	93109	broad.mit.edu	37	3	194343970	194343970	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:194343970G>A	ENST00000392432.2	-	5	800	c.595C>T	c.(595-597)Ccc>Tcc	p.P199S	TMEM44_ENST00000473092.1_Missense_Mutation_p.P199S|TMEM44_ENST00000381975.3_Missense_Mutation_p.P199S|TMEM44_ENST00000347147.4_Missense_Mutation_p.P199S|TMEM44_ENST00000330115.3_Missense_Mutation_p.P96S|TMEM44_ENST00000273580.7_Missense_Mutation_p.P199S	NM_001166305.1	NP_001159777.1	Q2T9K0	TMM44_HUMAN	transmembrane protein 44	199						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|urinary_tract(1)	8	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		GAGAGAGGGGGGATCCGAGAA	0.592000													7	11					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31743776	31743776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31743776G>A	ENST00000375686.3	-	3	715	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	VWA7_ENST00000447450.1_Missense_Mutation_p.R160C|VWA7_ENST00000467576.1_Intron|VWA7_ENST00000375688.4_Missense_Mutation_p.R160C	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	160						extracellular region											AGGCGCTGGCGAGCCAGGGTG	0.667000													61	116					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21031193	21031193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21031193C>T	ENST00000247986.2	-	5	1180	c.870G>A	c.(868-870)tcG>tcA	p.S290S	KIF17_ENST00000400463.3_Silent_p.S290S|KIF17_ENST00000375044.1_Silent_p.S190S			Q9P2E2	KIF17_HUMAN	kinesin family member 17	290					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GCGTCAGCTTCGAGTCACGGT	0.617000													26	67					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48606480	48606480	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48606480C>T	ENST00000323776.5	+	18	2946	c.2784C>T	c.(2782-2784)atC>atT	p.I928I	MYCBPAP_ENST00000436259.2_Silent_p.I891I	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	891					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CCCCTGACATCATCCTCTCTT	0.517000													21	47					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215901705	215901705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215901705C>T	ENST00000366943.2	-	61	12119	c.11733G>A	c.(11731-11733)gaG>gaA	p.E3911E	USH2A_ENST00000307340.3_Silent_p.E3911E			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3911	Fibronectin type-III 24.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.E3911D(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAACAGACTCCTCTTCAATGC	0.453000										HNSCC(13;0.011)			19	35					0	0	1	0	0
STPG1	90529	broad.mit.edu	37	1	24696301	24696301	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24696301C>T	ENST00000374409.1	-	7	854	c.600G>A	c.(598-600)gtG>gtA	p.V200V	STPG1_ENST00000003583.8_Silent_p.V153V|STPG1_ENST00000440416.1_Silent_p.V153V|STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000337248.4_Silent_p.V200V	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		GCGACTGCTTCACAAGGGATT	0.393000													13	118					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760621	19760621	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19760621T>G	ENST00000357324.6	-	18	2490	c.2464A>C	c.(2464-2466)Acc>Ccc	p.T822P	ATP13A1_ENST00000291503.5_Missense_Mutation_p.T704P	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	822					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						TGGGGGTCGGTGGCCTGCAGG	0.692000													7	33					0	0	1	0	0
TRIM24	8805	broad.mit.edu	37	7	138235915	138235915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138235915C>T	ENST00000343526.4	+	8	1466	c.1251C>T	c.(1249-1251)atC>atT	p.I417I	TRIM24_ENST00000415680.2_Silent_p.I417I|TRIM24_ENST00000497516.1_3'UTR			O15164	TIF1A_HUMAN	tripartite motif containing 24	417					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						CTCAAAATATCATCAACTTAG	0.418000													61	150					0	0	1	0	0
FAM105B	90268	broad.mit.edu	37	5	14693021	14693021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14693021C>T	ENST00000284274.4	+	7	1001	c.923C>T	c.(922-924)tCc>tTc	p.S308F		NM_138348.4	NP_612357.4	Q96BN8	F105B_HUMAN	family with sequence similarity 105, member B	308										breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	14	Lung NSC(4;0.00696)					TACCGGCTCTCCAAGTACAAC	0.522000													35	90					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5247885	5247885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5247885C>T	ENST00000335295.3	-	2	412	c.237G>A	c.(235-237)ctG>ctA	p.L79L		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	79			L -> R (in Quin-hai).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	TGAGGTTGTCCAGGTGAGCCA	0.542000									Sickle Cell Trait				25	109					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130761	20130761	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20130761C>T	ENST00000334554.7	+	10	1749	c.1608C>T	c.(1606-1608)ccC>ccT	p.P536P	ZDHHC8_ENST00000320602.7_Silent_p.P444P|ZDHHC8_ENST00000405930.3_Silent_p.P536P	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	536						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					CCCGGGAGCCCTCGCCTGTGC	0.706000													15	26					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170278	90170278	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:90170278G>A	ENST00000333209.3	-	2	1502	c.984C>T	c.(982-984)gtC>gtT	p.V328V		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	328										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		ATCTGCTCTCGACACTCGCCA	0.527000													42	93					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63019376	63019376	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:63019376G>A	ENST00000561311.1	+	27	3576	c.3346G>A	c.(3346-3348)Gaa>Aaa	p.E1116K	TLN2_ENST00000306829.6_Missense_Mutation_p.E1116K			Q9Y4G6	TLN2_HUMAN	talin 2	1116	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TCAAGGCAACGAACACTACAC	0.562000													7	49					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132237666	132237666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132237666G>A	ENST00000321253.6	+	4	507	c.400G>A	c.(400-402)Ggc>Agc	p.G134S	TUBA3D_ENST00000409047.2_3'UTR	NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	134					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		AGGACTGCAGGGCTTCCTCAT	0.587000													18	92					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3643301	3643301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3643301G>A	ENST00000335312.3	-	13	1677	c.1589C>T	c.(1588-1590)tCc>tTc	p.S530F	PIP5K1C_ENST00000539785.1_Missense_Mutation_p.S530F|PIP5K1C_ENST00000589578.1_Missense_Mutation_p.S530F|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.S530F	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	530					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		GAGGGATGTGGATGACAGAGT	0.662000													42	101					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58285269	58285269	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:58285269C>T	ENST00000249750.4	-	6	1325	c.558G>A	c.(556-558)tgG>tgA	p.W186*	ALDH1A2_ENST00000537372.1_Nonsense_Mutation_p.W165*|ALDH1A2_ENST00000558231.1_Nonsense_Mutation_p.W157*|ALDH1A2_ENST00000559517.1_Nonsense_Mutation_p.W90*|ALDH1A2_ENST00000347587.3_Nonsense_Mutation_p.W186*	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	186					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GGGGGAAGTTCCACTGAAAGG	0.418000													15	56					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33650113	33650113	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33650113G>A	ENST00000399362.4	-	14	1747	c.1394C>T	c.(1393-1395)tCa>tTa	p.S465L	CLASP2_ENST00000480013.1_Missense_Mutation_p.S232L|CLASP2_ENST00000313350.6_Missense_Mutation_p.S238L|CLASP2_ENST00000359576.5_Missense_Mutation_p.S465L|CLASP2_ENST00000468888.2_Missense_Mutation_p.S466L|CLASP2_ENST00000539981.1_Missense_Mutation_p.S217L|CLASP2_ENST00000461133.3_Missense_Mutation_p.S232L|CLASP2_ENST00000487200.1_Missense_Mutation_p.S238L|CLASP2_ENST00000307312.7_5'UTR|CLASP2_ENST00000333778.6_Missense_Mutation_p.S242L	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	466										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						AAATTCAAATGAACGTCTGAA	0.343000													9	18					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434306	72434306	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:72434306T>C	ENST00000373517.3	-	1	378	c.23A>G	c.(22-24)aAg>aGg	p.K8R	NAP1L2_ENST00000536638.1_Intron	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	8					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TGACAGCTCCTTGCGGTTCTC	0.547000													25	32					0	0	1	0	0
LINC00842	643650	broad.mit.edu	37	10	47133709	47133709	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:47133709G>A	ENST00000422732.2	-	0	435					NR_033957.1																						GAACCACTTCGACCTCTTTGG	0.468000													18	143					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37605969	37605969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:37605969C>T	ENST00000505425.1	-	16	2787	c.2788G>A	c.(2788-2790)Gaa>Aaa	p.E930K	MDGA1_ENST00000297153.7_Intron|MDGA1_ENST00000434837.2_Intron			Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	930					brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						CCACCTCCTTCCCGTCTTGCA	0.582000													18	27					0	0	1	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24523781	24523781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:24523781C>T	ENST00000376862.3	+	2	681	c.48C>T	c.(46-48)atC>atT	p.I16I		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	16					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						ACAGTAAAATCAGTGATGCTG	0.517000													31	66					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45914634	45914634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45914634C>T	ENST00000348697.2	+	2	299	c.152C>T	c.(151-153)tCg>tTg	p.S51L	FBLN1_ENST00000402984.3_Missense_Mutation_p.S51L|FBLN1_ENST00000327858.6_Missense_Mutation_p.S51L|FBLN1_ENST00000340923.5_Missense_Mutation_p.S51L|FBLN1_ENST00000442170.2_Missense_Mutation_p.S51L|FBLN1_ENST00000262722.7_Missense_Mutation_p.S51L			P23142	FBLN1_HUMAN	fibulin 1	51	Anaphylatoxin-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding	p.S51W(3)		biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		AAGGACTGCTCGCTGCCATAT	0.552000													5	10					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149460492	149460492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149460492C>T	ENST00000286301.3	-	3	436	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	CSF1R_ENST00000543093.1_Missense_Mutation_p.E49K	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	49	Ig-like C2-type 1.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CCATCCCATTCCACGCTGCCA	0.587000													13	24					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31672723	31672723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31672723C>T	ENST00000375483.3	+	4	703	c.703C>T	c.(703-705)Cct>Tct	p.P235S		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	235						cytoplasm|extracellular region	lipid binding										GCTGACCCTCCCTCGGGTGTC	0.667000													15	16					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69320593	69320593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:69320593C>T	ENST00000260364.5	+	4	460	c.159C>T	c.(157-159)tcC>tcT	p.S53S	NOX5_ENST00000448182.3_Silent_p.S53S|NOX5_ENST00000530406.2_Silent_p.S71S|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000455873.3_Silent_p.S64S|NOX5_ENST00000388866.3_Silent_p.S71S			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	71	EF-hand 1.|N-terminal regulatory region; interacts with the C-terminal catalytic region in a calcium-dependent manner.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						TATTTGACTCCGATAGAAGTG	0.552000													34	197					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890849	23890849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23890849G>A	ENST00000532292.1	-	1	326	c.232C>T	c.(232-234)Ccg>Tcg	p.P78S		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GGCTGGAGCGGCAGTGTGGGC	0.667000													3	15					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12270755	12270755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12270755C>T	ENST00000256194.4	+	22	3097	c.2809C>T	c.(2809-2811)Cat>Tat	p.H937Y	MICAL2_ENST00000379612.3_Missense_Mutation_p.H747Y|MICAL2_ENST00000342902.5_Intron|MICAL2_ENST00000527546.1_Missense_Mutation_p.H747Y|MICAL2_ENST00000537344.1_Missense_Mutation_p.H747Y	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	937						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		ttcagggttccattttcatcc	0.458000													25	49					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814477	242814477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242814477G>A	ENST00000343216.3	+	2	798	c.770G>A	c.(769-771)gGg>gAg	p.G257E		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	257						integral to membrane											GCCATGCCTGGGGGCAAAGGC	0.667000													19	39					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144769802	144769802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:144769802C>T	ENST00000367545.3	+	16	1969	c.1969C>T	c.(1969-1971)Cgt>Tgt	p.R657C		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	657	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding	p.R657C(1)		NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GGAGACTGTTCGTGTAAGAGA	0.423000													18	113					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79025987	79025987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79025987G>A	ENST00000446378.2	+	2	1430	c.1399G>A	c.(1399-1401)Gaa>Aaa	p.E467K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	467						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGAAAGGGCAGAACCAGTCTC	0.512000													38	116					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33895342	33895342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33895342C>T	ENST00000389232.4	+	18	2011	c.1941C>T	c.(1939-1941)ttC>ttT	p.F647F	RYR3_ENST00000415757.3_Silent_p.F647F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	647	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAAACATCTTCCTGGGAGTCG	0.522000													22	109					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37482128	37482128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37482128G>A	ENST00000374660.1	+	33	2844	c.2745G>A	c.(2743-2745)atG>atA	p.M915I	ANKRD30A_ENST00000475522.1_3'UTR|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.M796I|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.M796I			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	967						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CCTGCAGAATGAAAGTTTCTA	0.269000													44	97					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28996398	28996398	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:28996398G>A	ENST00000322982.3	-	0	1536							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										AGCGGTCAGGGAAGCTGAGGG	0.687000													18	69					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192053172	192053172	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:192053172C>G	ENST00000454309.2	-	3	1217	c.392G>C	c.(391-393)gGt>gCt	p.G131A	FGF12_ENST00000430714.1_Missense_Mutation_p.G32A|FGF12_ENST00000450716.1_Missense_Mutation_p.G69A|FGF12_ENST00000264730.3_Missense_Mutation_p.G69A|FGF12_ENST00000445105.1_Missense_Mutation_p.G69A	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	131					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		ATAGCCTTCACCATTCATGGC	0.463000													22	98					0	0	1	0	0
LANCL3	347404	broad.mit.edu	37	X	37518741	37518741	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37518741C>T	ENST00000378621.3	+	3	1026	c.724C>T	c.(724-726)Ctt>Ttt	p.L242F	TM4SF2_ENST00000465127.1_Intron|LANCL3_ENST00000378619.3_Missense_Mutation_p.L242F	NM_198511.2	NP_940913.1	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3 (bacterial)	242							catalytic activity			lung(4)|pancreas(1)	5						GTCGTCTATTCTTCAGATGCT	0.433000													15	19					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25572670	25572670	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:25572670G>A	ENST00000269141.3	-	9	1716	c.1293C>T	c.(1291-1293)ttC>ttT	p.F431F	CDH2_ENST00000399380.3_Silent_p.F400F	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	431	Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TCTGGATGGCGAACCGTCCAG	0.527000													31	84					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43847746	43847746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43847746C>T	ENST00000389420.3	-	12	1723	c.1724G>A	c.(1723-1725)gGa>gAa	p.G575E	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.G575E	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	575	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACTTTCGATTCCGCCTCCACA	0.418000													6	15					0	0	1	0	0
FLAD1	80308	broad.mit.edu	37	1	154960590	154960590	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154960590C>T	ENST00000368433.1	+	2	725	c.382C>T	c.(382-384)Cag>Tag	p.Q128*	FLAD1_ENST00000315144.10_Nonsense_Mutation_p.Q31*|FLAD1_ENST00000368432.1_Nonsense_Mutation_p.Q31*|FLAD1_ENST00000292180.3_Nonsense_Mutation_p.Q128*|FLAD1_ENST00000487371.1_3'UTR|FLAD1_ENST00000295530.2_5'UTR|FLAD1_ENST00000405236.2_Nonsense_Mutation_p.Q29*|FLAD1_ENST00000368431.3_Nonsense_Mutation_p.Q29*			Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	128	Molybdenum cofactor biosynthesis protein- like.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGGACACACTCAGGACACCAA	0.562000													46	148					0	0	1	0	0
NUAK1	9891	broad.mit.edu	37	12	106460850	106460850	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:106460850G>A	ENST00000261402.2	-	7	3095	c.1716C>T	c.(1714-1716)atC>atT	p.I572I		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	572							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TGTCATCGCTGATGACACTGG	0.617000													18	28					0	0	1	0	0
KCNJ16	3773	broad.mit.edu	37	17	68129141	68129141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:68129141C>T	ENST00000585558.1	+	4	1406	c.1018C>T	c.(1018-1020)Ctc>Ttc	p.L340F	KCNJ16_ENST00000392670.1_Missense_Mutation_p.L305F|KCNJ16_ENST00000392671.1_Missense_Mutation_p.L305F|KCNJ16_ENST00000589377.1_Missense_Mutation_p.L305F|KCNJ16_ENST00000586462.1_Missense_Mutation_p.L344F|KCNJ16_ENST00000283936.1_Missense_Mutation_p.L305F			Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 16	305					synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	32	Breast(10;2.96e-09)					CCGAGAAATTCTCTGGGGCCA	0.403000													33	116					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071953	9071953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9071953G>A	ENST00000397910.4	-	3	15696	c.15493C>T	c.(15493-15495)Cct>Tct	p.P5165S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5167	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATGTGGAAGGAGCTGGATCT	0.488000													57	195					0	0	1	0	0
TMEM8B	51754	broad.mit.edu	37	9	35853227	35853227	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35853227C>T	ENST00000377988.2	+	12	2344	c.1056C>T	c.(1054-1056)ttC>ttT	p.F352F	TMEM8B_ENST00000377991.4_Silent_p.F352F	NM_001042590.2	NP_001036055.1	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B	352					cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	7						CCAGTCTCTTCGCCCTGGGGA	0.612000													28	105					0	0	1	0	0
PDIK1L	149420	broad.mit.edu	37	1	26440953	26440953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26440953C>T	ENST00000374271.4	+	3	441	c.154C>T	c.(154-156)Cgt>Tgt	p.R52C	PDIK1L_ENST00000374269.1_Missense_Mutation_p.R52C	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	52	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		ACTAGCCCTTCGTGAGTTCTG	0.458000													10	34					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128564722	128564722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:128564722C>T	ENST00000335251.5	+	2	296	c.193C>T	c.(193-195)Ctg>Ttg	p.L65L	INTU_ENST00000296461.5_Silent_p.L65L	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	65										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						AAATGGAGAGCTGTTTTATTT	0.388000													81	222					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331609	85331609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85331609G>A	ENST00000440886.1	-	1	233	c.195C>T	c.(193-195)ttC>ttT	p.F65F	LPAR3_ENST00000370611.3_Silent_p.F65F|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	65					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						ACAGGTAGTAGAAGGGGAAAT	0.393000													26	129					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95132727	95132727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95132727G>A	ENST00000371501.4	-	24	2539	c.2417C>T	c.(2416-2418)tCt>tTt	p.S806F	MYOF_ENST00000358334.5_Missense_Mutation_p.S793F|MYOF_ENST00000359263.4_Missense_Mutation_p.S806F|MYOF_ENST00000371502.4_Missense_Mutation_p.S806F			Q9NZM1	MYOF_HUMAN	myoferlin	806					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GTATTTTCCAGATGCATTCTC	0.453000													10	134					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151927040	151927040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151927040G>A	ENST00000355193.2	-	18	3162	c.2944C>T	c.(2944-2946)Cag>Tag	p.Q982*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.Q982*					lysine (K)-specific methyltransferase 2C																		TGGTAACACTGACCACACTGA	0.343000													26	472					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3823288	3823288	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3823288C>T	ENST00000262961.4	-	8	1337	c.1327G>A	c.(1327-1329)Ggc>Agc	p.G443S		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	443						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		TCAGAGCAGCCCGCGGGAGCT	0.627000													45	128					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6753012	6753012	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:6753012C>T	ENST00000230859.6	+	12	1425	c.1296C>T	c.(1294-1296)acC>acT	p.T432T		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	432					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CTCCACCGACCCTAGGGGTTG	0.527000													31	73					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11150225	11150225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11150225C>T	ENST00000358026.2	+	30	4546	c.4262C>T	c.(4261-4263)tCa>tTa	p.S1421L	SMARCA4_ENST00000450717.3_Intron|SMARCA4_ENST00000413806.3_Intron|SMARCA4_ENST00000444061.3_Intron|SMARCA4_ENST00000344626.4_Intron|SMARCA4_ENST00000541122.2_Intron|SMARCA4_ENST00000590574.1_Intron|SMARCA4_ENST00000589677.1_Intron|SMARCA4_ENST00000429416.3_Intron	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1389					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACACGTGCGTCAAAGGTGGGG	0.527000			"""F, N, Mis"""		NSCLC								3	18					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98808818	98808818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98808818G>A	ENST00000266058.4	-	14	1604	c.1359C>T	c.(1357-1359)ttC>ttT	p.F453F	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.F453F	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	453	LRRCT 2.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TGGTGCGCAGGAAGTCTGCCA	0.587000													26	77					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62744636	62744636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62744636C>T	ENST00000377871.3	-	9	1851	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	SLC22A6_ENST00000458333.2_Intron|SLC22A6_ENST00000421062.2_Missense_Mutation_p.E485K|SLC22A6_ENST00000360421.4_Intron	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	529					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						atccctgcttctttctgagTG	0.607000													19	173					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43259928	43259928	+	Silent	SNP	G	G	A	rs140077118		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43259928G>A	ENST00000422911.1	-	7	887	c.786C>T	c.(784-786)agC>agT	p.S262S	PRDM15_ENST00000269844.3_Silent_p.S591S|PRDM15_ENST00000398548.1_Silent_p.S262S|PRDM15_ENST00000447207.2_Silent_p.S225S|PRDM15_ENST00000538201.1_Silent_p.S225S			P57071	PRD15_HUMAN	PR domain containing 15	591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CTGGAGGAAGGCTTTTGGCTT	0.602000													42	134					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228469732	228469732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228469732G>A	ENST00000570156.2	+	36	9657	c.9583G>A	c.(9583-9585)Gac>Aac	p.D3195N	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.D2766N|OBSCN_ENST00000284548.11_Missense_Mutation_p.D2766N|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000359599.6_Missense_Mutation_p.D1613N	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2195	Ig-like 32.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GAGTGCCAGCGACCCGGCCAT	0.617000													18	25					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114136107	114136107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:114136107G>A	ENST00000356116.1	+	1	152	c.40G>A	c.(40-42)Gag>Aag	p.E14K	ACSL5_ENST00000433418.1_5'UTR|ACSL5_ENST00000479936.1_Intron|ACSL5_ENST00000393081.1_Intron|ACSL5_ENST00000354273.4_5'UTR|ACSL5_ENST00000354655.4_Intron	NM_016234.3	NP_057318.2	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	0					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GAGGAACCACGAGCGAGGGAA	0.632000													42	101					0	0	1	0	0
TRBV5-6	28609	broad.mit.edu	37	7	142131517	142131517	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142131517G>A	ENST00000390375.2	-	0	278																											AATCGATCAGGGAAGTTGCCT	0.537000													28	76					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71163622	71163622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71163622C>T	ENST00000393567.2	-	9	1298	c.1148G>A	c.(1147-1149)cGa>cAa	p.R383Q	HYDIN_ENST00000538248.1_Missense_Mutation_p.R410Q|HYDIN_ENST00000321489.5_Missense_Mutation_p.R383Q|HYDIN_ENST00000448089.2_Missense_Mutation_p.R383Q|HYDIN_ENST00000448691.1_Missense_Mutation_p.R383Q|HYDIN_ENST00000288168.10_Missense_Mutation_p.R400Q|HYDIN_ENST00000393550.2_Missense_Mutation_p.R383Q|HYDIN_ENST00000541601.1_Missense_Mutation_p.R400Q	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	383										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CGCAAAGGTTCGGGACAGAAC	0.443000													15	31					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162875326	162875326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:162875326G>A	ENST00000360534.3	-	16	1893	c.1333C>T	c.(1333-1335)Ctc>Ttc	p.L445F		NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	445					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	TCACAACTGAGGCATGTCACT	0.403000													32	83					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75108723	75108723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75108723G>A	ENST00000326665.5	-	4	521	c.303C>T	c.(301-303)atC>atT	p.I101I		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	101										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TAAACCTCTGGATTCGCTCCT	0.338000													28	73					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41015551	41015551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41015551C>T	ENST00000399564.4	-	29	3364	c.2914G>A	c.(2914-2916)Ggt>Agt	p.G972S	MROH2B_ENST00000506092.2_Missense_Mutation_p.G527S	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TCCTGCAAACCCTGCAGTCTT	0.413000													19	53					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48800737	48800737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48800737C>T	ENST00000315396.7	-	14	2191	c.1509G>A	c.(1507-1509)aaG>aaA	p.K503K		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	503										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CGGCCAGGTCCTTCTGGCGCT	0.736000													4	20					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40438554	40438554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40438554G>A	ENST00000381793.2	-	4	1630	c.1234C>T	c.(1234-1236)Cat>Tat	p.H412Y	RBM47_ENST00000381795.6_Intron|RBM47_ENST00000295971.7_Missense_Mutation_p.H412Y|RBM47_ENST00000514014.1_Missense_Mutation_p.H374Y|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000319592.4_Intron			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	412						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						TTCCCTTCATGATATCGGCTA	0.522000													19	238					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83331569	83331569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83331569C>T	ENST00000261722.3	-	22	2860	c.2653G>A	c.(2653-2655)Gat>Aat	p.D885N	AP3B2_ENST00000535348.1_Missense_Mutation_p.D853N|AP3B2_ENST00000535359.1_Missense_Mutation_p.D904N|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	885					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			ATGTGGGGATCCCCGGAGAAA	0.622000													21	15					0	0	1	0	0
GRWD1	83743	broad.mit.edu	37	19	48956279	48956279	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48956279C>A	ENST00000253237.5	+	7	1571	c.1338C>A	c.(1336-1338)gtC>gtA	p.V446V		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	446						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		CCATCAGCGTCTGAGGCGTCC	0.602000													14	54					1.52009e-12	1.52731e-12	1	1	0
TOP1MT	116447	broad.mit.edu	37	8	144408461	144408461	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144408461G>A	ENST00000523676.1	-	5	525	c.120C>T	c.(118-120)ttC>ttT	p.F40F	TOP1MT_ENST00000521193.1_Silent_p.F40F|TOP1MT_ENST00000519148.1_Silent_p.F40F|TOP1MT_ENST00000329245.4_Silent_p.F138F			Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	138					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	GGATCTCCGTGAAGTCACACT	0.557000													62	103					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170066148	170066148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170066148C>T	ENST00000263816.3	-	38	6569	c.6284G>A	c.(6283-6285)cGa>cAa	p.R2095Q		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2095					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.R2095Q(2)		biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAGTGCGTTTCGTCCTGGAAG	0.413000													13	48					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979735	12979735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12979735G>A	ENST00000361079.2	+	4	1010	c.927G>A	c.(925-927)ttG>ttA	p.L309L						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGTCGGACTTGAAGCATCTCT	0.567000													14	138					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13742516	13742516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:13742516C>T	ENST00000383314.2	+	8	1244	c.1004C>T	c.(1003-1005)tCa>tTa	p.S335L	RNMT_ENST00000589866.1_Missense_Mutation_p.S335L|RNMT_ENST00000592764.1_Missense_Mutation_p.S335L|RNMT_ENST00000543302.2_Missense_Mutation_p.S335L|RNMT_ENST00000535051.1_Missense_Mutation_p.S93L|RNMT_ENST00000262173.3_Missense_Mutation_p.S335L			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	335					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						GAAACAGAATCATTTGGAAAT	0.328000													40	82					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559123	140559123	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140559123C>T	ENST00000239444.2	+	1	1753	c.1508C>T	c.(1507-1509)tCc>tTc	p.S503F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		503	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCTCGCCTCCCTGGTCTCC	0.667000													59	314					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125015581	125015581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125015581G>A	ENST00000522917.1	+	13	1900	c.1694G>A	c.(1693-1695)gGg>gAg	p.G565E	FER1L6_ENST00000399018.1_Missense_Mutation_p.G565E|FER1L6-AS1_ENST00000518567.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	565						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTGACAGAAGGGAACAGGTAG	0.502000													11	39					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111870807	111870807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111870807C>T	ENST00000305815.5	-	28	3673	c.3421G>A	c.(3421-3423)Gga>Aga	p.G1141R	SLC9C1_ENST00000487372.1_Missense_Mutation_p.G1093R	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	1141					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										CTGTGTGCTCCATCCTGGGAT	0.522000													26	40					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15065098	15065098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15065098G>A	ENST00000430939.2	-	7	1150	c.1021C>T	c.(1021-1023)Ctg>Ttg	p.L341L	SLC1A6_ENST00000221742.3_Silent_p.L405L|SLC1A6_ENST00000600144.1_Silent_p.L327L			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	405					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	TCCACACCCAGGCCCTCCTCC	0.687000													33	60					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229235	21229235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21229235C>T	ENST00000233242.1	-	26	10632	c.10505G>A	c.(10504-10506)gGt>gAt	p.G3502D		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3502	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAGAACCGAACCCTTGACATC	0.468000													47	101					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70946680	70946680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70946680G>A	ENST00000334414.6	-	21	5308	c.5264C>T	c.(5263-5265)cCt>cTt	p.P1755L	PTPRB_ENST00000550358.1_Missense_Mutation_p.P1667L|PTPRB_ENST00000261266.5_Missense_Mutation_p.P1537L|PTPRB_ENST00000451516.2_Missense_Mutation_p.P1447L|PTPRB_ENST00000538708.1_Missense_Mutation_p.P1447L|PTPRB_ENST00000550857.1_Missense_Mutation_p.P1447L	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1537	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTTGCTGTTAGGATTTTCGGC	0.468000													28	93					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427031	135427031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135427031C>T	ENST00000394143.1	+	6	1457	c.1166C>T	c.(1165-1167)tCa>tTa	p.S389L	GPR112_ENST00000370652.1_Missense_Mutation_p.S389L|GPR112_ENST00000394141.1_Missense_Mutation_p.S184L|GPR112_ENST00000412101.1_Missense_Mutation_p.S184L|GPR112_ENST00000287534.4_Missense_Mutation_p.S326L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	389					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TCTACAACTTCAGCAATTAAA	0.368000													48	29					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916457	42916457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42916457C>T	ENST00000316161.4	-	1	1176	c.852G>A	c.(850-852)caG>caA	p.Q284Q	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.Q284Q|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	284					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCGTGTTCCCCTGGGAGGCCC	0.582000													8	17					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43268903	43268903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43268903G>A	ENST00000372585.5	+	6	953	c.858G>A	c.(856-858)ctG>ctA	p.L286L	SLC22A7_ENST00000487175.1_3'UTR|SLC22A7_ENST00000372589.3_Silent_p.L284L|SLC22A7_ENST00000372574.3_Silent_p.L284L	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	286						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GCTGGCTTCTGACCCAAGGCC	0.572000													35	69					0	0	1	0	0
WDR45B	56270	broad.mit.edu	37	17	80579640	80579640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80579640G>A	ENST00000392325.4	-	6	657	c.463C>T	c.(463-465)Ctc>Ttc	p.L155F	WDR45B_ENST00000571835.1_5'UTR	NM_019613.3	NP_062559.2			WD repeat domain 45B																		AAGGCCAGGAGGGAGTTGTTA	0.567000													11	35					0	0	1	0	0
ZNF549	256051	broad.mit.edu	37	19	58049491	58049491	+	Silent	SNP	C	C	T	rs138206012		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58049491C>T	ENST00000376233.3	+	4	1300	c.1119C>T	c.(1117-1119)tcC>tcT	p.S373S	ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000240719.3_Silent_p.S360S|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTATTCATTCCTATGACCGCA	0.443000													24	59					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169696962	169696962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169696962C>T	ENST00000333360.7	-	9	1525	c.1386G>A	c.(1384-1386)gaG>gaA	p.E462E	SELE_ENST00000367780.4_Silent_p.E337E|SELE_ENST00000367781.4_Silent_p.E399E|SELE_ENST00000367779.4_Intron|SELE_ENST00000367782.4_Intron|SELE_ENST00000367777.1_Intron|SELE_ENST00000367775.1_Silent_p.E337E|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367776.1_Silent_p.E399E|SELE_ENST00000367774.1_Intron	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	462	Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					CAAATCCCTCCTCACAGCTGA	0.502000													33	118					0	0	1	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73490866	73490866	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:73490866A>C	ENST00000556143.1	-	2	1071	c.351T>G	c.(349-351)ccT>ccG	p.P117P	ZFYVE1_ENST00000553891.1_Silent_p.P117P|ZFYVE1_ENST00000318876.5_Silent_p.P117P	NM_021260.2	NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	117						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		ACACAGTAACAGGGTGTCTCC	0.483000													94	236					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915458	46915458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46915458C>T	ENST00000307522.3	-	1	1383	c.610G>A	c.(610-612)Ggg>Agg	p.G204R		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	204						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		TTCAGCTTCCCCCAGGACACC	0.697000													14	21					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916520	42916520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42916520C>T	ENST00000316161.4	-	1	1113	c.789G>A	c.(787-789)agG>agA	p.R263R	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.R263R|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	263					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCCCCTGCTCCCTCAGAAACT	0.582000													8	19					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158524020	158524020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:158524020C>T	ENST00000313708.6	-	2	535	c.253G>A	c.(253-255)Gag>Aag	p.E85K	EBF1_ENST00000380654.4_Missense_Mutation_p.E85K|EBF1_ENST00000517373.1_Missense_Mutation_p.E85K|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	85					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTGTCCTCTCGATCTCCACG	0.627000			T	HMGA2	lipoma								4	30					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150443463	150443463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150443463C>T	ENST00000401000.4	+	10	2026	c.1961C>T	c.(1960-1962)cCt>cTt	p.P654L	RPRD2_ENST00000539519.1_Missense_Mutation_p.P654L|RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.P680L			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	680	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						AAAGGTAATCCTGGTTTCAGT	0.507000													29	64					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981797	61981797	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61981797G>A	ENST00000370263.4	-	5	1187	c.966C>T	c.(964-966)gtC>gtT	p.V322V	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	322					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AGACCGTGATGACGATGGACA	0.607000													35	82					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79418033	79418033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79418033C>T	ENST00000264895.6	+	60	9473	c.9033C>T	c.(9031-9033)ggC>ggT	p.G3011G		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3006					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCTACCTCGGCCTTCCTCTTG	0.453000													37	128					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111981908	111981908	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111981908G>A	ENST00000305815.5	-	10	1312	c.1060C>T	c.(1060-1062)Cga>Tga	p.R354*	SLC9C1_ENST00000487372.1_Nonsense_Mutation_p.R306*	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	354					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										TGACCAACTCGAGACAAAACA	0.373000													38	94					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234858655	234858655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234858655C>T	ENST00000324695.4	+	9	1045	c.1005C>T	c.(1003-1005)atC>atT	p.I335I	AC005538.5_ENST00000455991.1_RNA|TRPM8_ENST00000433712.2_Silent_p.I23I	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	335						integral to membrane		p.I335I(1)		breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CGGGCCAGATCGCTGATGTGA	0.552000													18	42					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100130033	100130033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100130033G>A	ENST00000394897.1	-	6	702	c.620C>T	c.(619-621)tCt>tTt	p.S207F	RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000407820.2_5'UTR|ADH6_ENST00000237653.7_Missense_Mutation_p.S207F|ADH6_ENST00000394899.2_Missense_Mutation_p.S207F|ADH6_ENST00000504257.1_5'UTR			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	207					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	CATGACAACAGACAAGCCGAC	0.473000													39	274					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8531250	8531250	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8531250C>T	ENST00000348943.3	+	8	877	c.645C>T	c.(643-645)tcC>tcT	p.S215S	HNRNPM_ENST00000325495.4_Silent_p.S254S	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	254	RRM 2.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						TTGAACAGTCCATTGAAGCTG	0.398000													51	135					0	0	1	0	0
TEX13B	56156	broad.mit.edu	37	X	107224759	107224759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107224759C>T	ENST00000302917.1	-	3	582	c.490G>A	c.(490-492)Gct>Act	p.A164T		NM_031273.2	NP_112563.1	Q9BXU2	TX13B_HUMAN	testis expressed 13B	164										breast(1)|endometrium(5)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28						AACACTGTAGCCTGGCCCTGT	0.642000													58	48					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240871	3240871	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3240871G>A	ENST00000217939.6	-	5	3009	c.2855C>T	c.(2854-2856)tCa>tTa	p.S952L		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	952						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGGCTCTGGTGACGATCCAAC	0.507000													17	28					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62239438	62239438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:62239438G>A	ENST00000261517.5	-	43	4903	c.4830C>T	c.(4828-4830)gtC>gtT	p.V1610V	VPS13C_ENST00000249837.3_Silent_p.V1567V|VPS13C_ENST00000395896.4_Silent_p.V1610V|VPS13C_ENST00000395898.3_Silent_p.V1567V	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	1610					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						CACAGACAAAGACATTAAATG	0.308000													51	151					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148809282	148809282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148809282G>A	ENST00000378061.2	-	3	383	c.251C>T	c.(250-252)cCt>cTt	p.P84L	ZNF425_ENST00000484196.1_5'UTR	NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	84					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.P84H(1)		breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			ATCAGTAGGAGGGCTAGTTGT	0.378000													16	201					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150163996	150163996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150163996C>T	ENST00000307271.3	+	2	784	c.210C>T	c.(208-210)ttC>ttT	p.F70F		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	70						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CTGACCTTTTCTCCTCAATAG	0.493000													69	137					0	0	1	0	0
GLT8D2	83468	broad.mit.edu	37	12	104387256	104387256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104387256C>T	ENST00000360814.4	-	10	1199	c.794G>A	c.(793-795)gGa>gAa	p.G265E	GLT8D2_ENST00000548660.1_Missense_Mutation_p.G265E|GLT8D2_ENST00000546436.1_Missense_Mutation_p.G265E	NM_031302.3	NP_112592.1	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	265						integral to membrane	transferase activity, transferring glycosyl groups			kidney(3)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						CACCCCTCCTCCCAGGGAGCT	0.458000													5	41					0	0	1	0	0
HOXB13	10481	broad.mit.edu	37	17	46805604	46805604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46805604C>T	ENST00000290295.7	-	1	936	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	118					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GGGTACTCTTCCCCGGCCGTG	0.652000													51	99					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9086960	9086960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9086960C>T	ENST00000397910.4	-	1	5058	c.4855G>A	c.(4855-4857)Gag>Aag	p.E1619K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1619	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGCCAGTCTCAATCTCTCTG	0.512000													56	143					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114304291	114304291	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114304291G>A	ENST00000309235.5	+	6	1234	c.1076G>A	c.(1075-1077)cGg>cAg	p.R359Q	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	359					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GAAAAGTCACGGAAATCTAAT	0.438000													40	66					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131908343	131908343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131908343G>A	ENST00000359827.3	-	9	3002	c.2040C>T	c.(2038-2040)gtC>gtT	p.V680V	PLXNA4_ENST00000321063.4_Silent_p.V680V			Q9HCM2	PLXA4_HUMAN	plexin A4	680	PSI 2.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CATGGGTGCAGACATGCCGGT	0.587000													8	22					0	0	1	0	0
PEX13	5194	broad.mit.edu	37	2	61275754	61275754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:61275754C>T	ENST00000295030.4	+	4	1099	c.1061C>T	c.(1060-1062)tCt>tTt	p.S354F		NM_002618.3	NP_002609.1	Q92968	PEX13_HUMAN	peroxisomal biogenesis factor 13	354					cerebral cortex cell migration|fatty acid alpha-oxidation|locomotory behavior|microtubule-based peroxisome localization|neuron migration|protein import into peroxisome matrix, docking|suckling behavior	integral to peroxisomal membrane|membrane fraction	protein binding			endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10			LUSC - Lung squamous cell carcinoma(5;2.05e-06)|Lung(5;3.13e-05)|Epithelial(17;0.114)			CAGCAACAATCTTTTACCAAC	0.383000													27	99					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175048558	175048558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175048558G>A	ENST00000239462.4	+	3	612	c.499G>A	c.(499-501)Gag>Aag	p.E167K		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	167	EGF-like 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCCCGCCTGCGAGCGGCTGGC	0.731000													4	9					0	0	1	0	0
SULT2A1	6822	broad.mit.edu	37	19	48374717	48374717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48374717C>T	ENST00000222002.3	-	6	992	c.853G>A	c.(853-855)Gaa>Aaa	p.E285K		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	285					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		GGACGTTATTCCCATGGGAAC	0.428000													22	77					0	0	1	0	0
FTMT	94033	broad.mit.edu	37	5	121187759	121187759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121187759C>T	ENST00000321339.1	+	1	110	c.101C>T	c.(100-102)cCg>cTg	p.P34L		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	34					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CGTTGGGCCCCGGGGCGCCCC	0.766000													11	16					0	0	1	0	0
HHATL	57467	broad.mit.edu	37	3	42739655	42739655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42739655G>A	ENST00000441594.1	-	6	933	c.672C>T	c.(670-672)acC>acT	p.T224T	HHATL_ENST00000310417.5_Silent_p.T224T	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	224					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		AGCGATCAAAGGTCATGATGG	0.527000													33	62					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44575962	44575962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44575962C>T	ENST00000289547.4	-	4	1802	c.1747G>A	c.(1747-1749)Gac>Aac	p.D583N	NPC1L1_ENST00000546276.1_Missense_Mutation_p.D583N|NPC1L1_ENST00000423141.1_Missense_Mutation_p.D583N|NPC1L1_ENST00000381160.3_Missense_Mutation_p.D583N	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	583					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AGACGGGGGTCCCCGGCAGGG	0.567000													28	70					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125284948	125284948	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125284948C>T	ENST00000431078.1	+	10	1925	c.1561C>T	c.(1561-1563)Cag>Tag	p.Q521*		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	521	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TATTGATAACCAGCCCAAGGA	0.443000													31	77					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71705447	71705447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71705447G>A	ENST00000356340.3	+	35	2492	c.1956G>A	c.(1954-1956)ggG>ggA	p.G652G	COL13A1_ENST00000517713.1_Silent_p.G603G|COL13A1_ENST00000398973.3_Silent_p.G626G|COL13A1_ENST00000398972.3_Silent_p.G638G|COL13A1_ENST00000357811.3_Silent_p.G618G|COL13A1_ENST00000398966.3_Silent_p.G630G|COL13A1_ENST00000522165.1_Silent_p.G621G|COL13A1_ENST00000398971.3_Silent_p.G637G|COL13A1_ENST00000520133.1_Silent_p.G574G|COL13A1_ENST00000520267.1_Silent_p.G580G|COL13A1_ENST00000398968.3_Silent_p.G633G|COL13A1_ENST00000398978.3_Silent_p.G652G|COL13A1_ENST00000398974.3_Silent_p.G640G|COL13A1_ENST00000398964.3_Silent_p.G623G|COL13A1_ENST00000354547.3_Silent_p.G630G|COL13A1_ENST00000398969.3_Silent_p.G580G			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	652	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	GAGACCCTGGGATGACAGGAC	0.527000													7	18					0	0	1	0	0
TPST2	8459	broad.mit.edu	37	22	26936880	26936880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26936880C>T	ENST00000338754.4	-	3	987	c.717G>A	c.(715-717)gaG>gaA	p.E239E	TPST2_ENST00000403880.1_Silent_p.E239E|TPST2_ENST00000398110.2_Silent_p.E239E	NM_003595.3	NP_003586.3	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	239					peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)|large_intestine(1)|lung(5)	7						GCACCAGCTGCTCGTAGTACA	0.597000													18	51					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55594959	55594959	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55594959G>A	ENST00000378397.1	+	1	265	c.265G>A	c.(265-267)Gac>Aac	p.D89N		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				CTTTAACAAGGACAAAGCCAT	0.473000										HNSCC(27;0.073)			78	209					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18865907	18865907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18865907C>T	ENST00000447925.2	-	6	846	c.577G>A	c.(577-579)Gga>Aga	p.G193R	PLCZ1_ENST00000538330.1_5'UTR|PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000435379.1_Intron|PLCZ1_ENST00000541695.1_Missense_Mutation_p.G58R|PLCZ1_ENST00000266505.7_Missense_Mutation_p.G195R	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	195	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CAACGGCATCCTTTCACAAGG	0.358000													8	72					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231577	21231577	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21231577G>A	ENST00000233242.1	-	26	8290	c.8163C>T	c.(8161-8163)ttC>ttT	p.F2721F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2721				Missing (in Ref. 15; AAA51758).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGGGATTATGAATTCTGGAA	0.428000													80	190					0	0	1	0	0
PRRX2	51450	broad.mit.edu	37	9	132483027	132483027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:132483027C>T	ENST00000372469.4	+	3	827	c.600C>T	c.(598-600)ctC>ctT	p.L200L		NM_016307.3	NP_057391.1	Q99811	PRRX2_HUMAN	paired related homeobox 2	200						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|pancreas(1)	3		Ovarian(14;0.00556)				CAGATTATCTCTCCTGGACAG	0.662000													15	53					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51679045	51679045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51679045G>A	ENST00000409535.1	+	16	2581	c.2456G>A	c.(2455-2457)gGa>gAa	p.G819E	RAD54L2_ENST00000296477.3_Missense_Mutation_p.G513E	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	819	Helicase C-terminal.					nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TAAAGGGCCGGATGCTTGGGT	0.468000													16	53					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88853989	88853989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88853989G>A	ENST00000537554.1	-	2	4567	c.1005C>T	c.(1003-1005)gcC>gcT	p.A335A	CNR1_ENST00000549890.1_Silent_p.A335A|CNR1_ENST00000535130.1_Silent_p.A335A|CNR1_ENST00000369499.2_Silent_p.A335A|CNR1_ENST00000369501.2_Silent_p.A335A|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000428600.2_Silent_p.A335A|CNR1_ENST00000549716.1_Silent_p.A274A|CNR1_ENST00000468898.1_Silent_p.A302A	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	335					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	TGTCCATGCGGGCTTGGTCTG	0.562000													44	66					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13399748	13399748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13399748G>A	ENST00000254508.5	-	16	2384	c.2302C>T	c.(2302-2304)Ccg>Tcg	p.P768S		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	768					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TGCAGCAGCGGACAGGACATG	0.667000													20	88					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57713104	57713104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57713104C>T	ENST00000333493.4	+	5	669	c.508C>T	c.(508-510)Ctg>Ttg	p.L170L	GPR97_ENST00000327655.6_5'UTR|GPR97_ENST00000450388.3_Silent_p.L50L	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	170					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCGGCTCGGCCTGGGAGATGG	0.627000													14	63					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33785099	33785099	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:33785099C>T	ENST00000261326.5	+	6	1099	c.1078C>T	c.(1078-1080)Ctg>Ttg	p.L360L		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	360					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	CTACGTGGCCCTGTCCTCTCT	0.473000													11	100					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348165	140348165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348165C>T	ENST00000289269.5	+	1	2346	c.1814C>T	c.(1813-1815)aCc>aTc	p.T605I	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		605	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACCTGGTCACCAAAGTCATA	0.517000													18	40					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46946124	46946124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46946124C>T	ENST00000429979.1	-	3	1091	c.487G>A	c.(487-489)Gac>Aac	p.D163N	KIAA0226L_ENST00000378784.4_Missense_Mutation_p.D96N|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.D163N|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.D163N|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.D28N|KIAA0226L_ENST00000409879.2_Intron|KIAA0226L_ENST00000322896.6_Intron|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.D163N|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.D163N	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	163										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						AAAGCACTGTCAGTCTCAGGA	0.517000													9	32					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74823635	74823635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74823635G>A	ENST00000256362.4	+	2	390	c.149G>A	c.(148-150)gGc>gAc	p.G50D		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	50					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CGGGAGGGAGGCCCTGGCCTC	0.637000													10	100					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137642657	137642657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137642657G>A	ENST00000371817.3	+	13	2005	c.1591G>A	c.(1591-1593)Gat>Aat	p.D531N		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	531	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGGTGGCGGCGATGCGGGCTC	0.637000													10	46					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52473859	52473859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:52473859C>T	ENST00000219746.9	-	7	1293	c.1009G>A	c.(1009-1011)Gcc>Acc	p.A337T	TOX3_ENST00000407228.3_Missense_Mutation_p.A332T	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	337					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						ATGGTCTGGGCTTCTGCTGAC	0.433000													16	48					0	0	1	0	0
MARVELD2	153562	broad.mit.edu	37	5	68737434	68737434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:68737434C>T	ENST00000325631.5	+	7	1704	c.1630C>T	c.(1630-1632)Caa>Taa	p.Q544*	MARVELD2_ENST00000413223.2_Nonsense_Mutation_p.Q428*	NM_001038603.2|NM_001244734.1	NP_001033692.2|NP_001231663.1	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2	544					sensory perception of sound	integral to membrane|tight junction				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(4)|skin(1)|urinary_tract(1)	15		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		GCAAAGAATTCAAGAATATGA	0.249000													16	50					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7569464	7569464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7569464G>A	ENST00000379802.3	+	12	1806	c.1465G>A	c.(1465-1467)Gag>Aag	p.E489K	DSP_ENST00000418664.2_Missense_Mutation_p.E489K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	489	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGACAACAACGAGCGCAGCAA	0.527000													39	98					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34025231	34025231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34025231C>T	ENST00000374372.1	-	3	981	c.478G>A	c.(478-480)Gag>Aag	p.E160K	GDF5_ENST00000374369.3_Missense_Mutation_p.E160K			P43026	GDF5_HUMAN	growth differentiation factor 5	160					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CGAAACGGCTCCTTGGGCTCT	0.632000													24	89					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54364824	54364824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:54364824C>T	ENST00000306888.2	-	4	925	c.674G>A	c.(673-675)gGa>gAa	p.G225E	LNX1-AS1_ENST00000502373.1_RNA|LNX1_ENST00000263925.7_Missense_Mutation_p.G321E|FIP1L1_ENST00000507166.1_Intron	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	321						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AATGATGTCTCCTGGCAGTAG	0.488000													22	56					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61574598	61574598	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61574598C>T	ENST00000290866.4	+	25	3816	c.3792C>T	c.(3790-3792)ttC>ttT	p.F1264F	ACE_ENST00000577647.1_Intron|ACE_ENST00000290863.6_Silent_p.F690F|ACE_ENST00000413513.3_Silent_p.F649F|ACE_ENST00000490216.2_Intron|ACE_ENST00000428043.1_Intron|ACE_ENST00000421982.2_Silent_p.F469F	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	1264					arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TGCTGCTCTTCCTGGGCATCG	0.716000													4	9					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196883708	196883708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196883708G>A	ENST00000367416.2	+	8	1398	c.1261G>A	c.(1261-1263)Gaa>Aaa	p.E421K	CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000251424.4_Missense_Mutation_p.E175K|CFHR4_ENST00000367418.1_Missense_Mutation_p.E175K	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						ATTGGACTACGAATGCTACGA	0.393000													14	64					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115409800	115409800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115409800C>T	ENST00000369358.4	-	9	1128	c.884G>A	c.(883-885)gGc>gAc	p.G295D	NRAP_ENST00000360478.3_Missense_Mutation_p.G295D|NRAP_ENST00000359988.3_Missense_Mutation_p.G295D|NRAP_ENST00000369360.3_Missense_Mutation_p.G295D			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	295						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ACATACCTGGCCATATTGGTC	0.468000													33	184					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858500	9858500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9858500C>T	ENST00000396573.2	-	14	3210	c.2901G>A	c.(2899-2901)gtG>gtA	p.V967V	GRIN2A_ENST00000535259.1_Silent_p.V810V|GRIN2A_ENST00000404927.2_Silent_p.V967V|GRIN2A_ENST00000562109.1_Silent_p.V967V|GRIN2A_ENST00000330684.3_Silent_p.V967V|GRIN2A_ENST00000396575.2_Silent_p.V967V	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	967					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCCGGTTGGCCACAAATGTTT	0.458000													40	79					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369958	20369958	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20369958G>A	ENST00000593655.1	-	0	199																											GCTTTCTGGAGGGTCTACTAT	0.403000													19	79					0	0	1	0	0
CDR2	1039	broad.mit.edu	37	16	22358533	22358533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:22358533G>A	ENST00000268383.2	-	5	1425	c.1118C>T	c.(1117-1119)tCc>tTc	p.S373F		NM_001802.1	NP_001793.1	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2, 62kDa	373						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(48;0.0188)		GTGTGACAGGGAGTCCTGTTC	0.592000													15	79					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482341	142482341	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142482341G>A	ENST00000603901.1	+	0	721					NR_001296.3																						CTGGATTAAGGACACCATAGC	0.502000													28	106					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120989342	120989342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120989342C>T	ENST00000392793.1	+	7	1389	c.1118C>T	c.(1117-1119)tCa>tTa	p.S373L	TECTA_ENST00000264037.2_Missense_Mutation_p.S373L			O75443	TECTA_HUMAN	tectorin alpha	373	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CGCAGAGGTTCAGCCGTCTCC	0.537000													11	102					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762808	130762808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:130762808G>A	ENST00000392429.1	+	2	3619	c.1241G>A	c.(1240-1242)cGg>cAg	p.R414Q	TMEM200A_ENST00000296978.3_Missense_Mutation_p.R414Q|TMEM200A_ENST00000545622.1_Missense_Mutation_p.R414Q	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	414						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GCAGAACAACGGAAACATCCA	0.483000													27	33					0	0	1	0	0
RIMS3	9783	broad.mit.edu	37	1	41101655	41101655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:41101655G>A	ENST00000372684.3	-	4	761	c.292C>T	c.(292-294)Cgg>Tgg	p.R98W	RIMS3_ENST00000372683.1_Missense_Mutation_p.R98W	NM_014747.2	NP_055562.2	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	98					neurotransmitter transport	cell junction|synapse		p.R98W(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			CGTGTGACCCGGCTCCGCATC	0.682000													21	50					0	0	1	0	0
PNPLA5	150379	broad.mit.edu	37	22	44280179	44280179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44280179G>A	ENST00000216177.4	-	7	1128	c.996C>T	c.(994-996)ttC>ttT	p.F332F	PNPLA5_ENST00000597664.1_Silent_p.F332F|PNPLA5_ENST00000381198.2_Silent_p.F218F|PNPLA5_ENST00000593866.1_Silent_p.F218F	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	332					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				CCGAGTGCCAGAAGCGGGCCC	0.617000											OREG0026622	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	113					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067679	9067679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9067679G>A	ENST00000397910.4	-	3	19970	c.19767C>T	c.(19765-19767)tcC>tcT	p.S6589S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6591	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTATGTTTGTGGAAGGATACA	0.453000													48	111					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124515320	124515320	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124515320G>A	ENST00000296181.4	-	10	1904	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	ITGB5_ENST00000488466.1_5'UTR	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	536	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		ACTCGCTCTCGAAGCAGGAGC	0.602000													28	90					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2138110	2138110	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2138110C>T	ENST00000219476.3	+	40	5760	c.5130C>T	c.(5128-5130)ttC>ttT	p.F1710F	TSC2_ENST00000382538.6_Silent_p.F1595F|TSC2_ENST00000568454.1_Silent_p.F1654F|TSC2_ENST00000350773.4_Silent_p.F1687F|TSC2_ENST00000439673.2_Silent_p.F1607F|TSC2_ENST00000353929.4_Silent_p.F1667F|TSC2_ENST00000401874.2_Silent_p.F1643F	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1710	Rap-GAP.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				ACCTGCCCTTCGTGGCCCGCC	0.652000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				18	96					0	0	1	0	0
SCYL1	57410	broad.mit.edu	37	11	65293661	65293661	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65293661T>C	ENST00000524944.1	+	4	475	c.442T>C	c.(442-444)Ttc>Ctc	p.F148L	SCYL1_ENST00000420247.2_Missense_Mutation_p.F148L|SCYL1_ENST00000533862.1_Missense_Mutation_p.F148L|SCYL1_ENST00000527630.1_Missense_Mutation_p.F148L|SCYL1_ENST00000279270.6_Missense_Mutation_p.F148L|SCYL1_ENST00000525364.1_Missense_Mutation_p.F148L|SCYL1_ENST00000527009.1_Missense_Mutation_p.F5L|SCYL1_ENST00000270176.5_Missense_Mutation_p.F148L			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	148	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			ovary(1)|skin(1)	2						GGCCGCCGTGTTCGTGGACCG	0.637000													19	43					0	0	1	0	0
MIR329-2	574409	broad.mit.edu	37	14	101493518	101493518	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101493518C>T	ENST00000385029.1	+	0	82					NR_029968.1																						TTTCCAGTATCAAATCCCATC	0.463000													38	128					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	16021923	16021923	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:16021923G>A	ENST00000217246.4	+	16	1626	c.1231_splice	c.e16+1	p.A411_splice	MACROD2_ENST00000310348.4_Splice_Site_p.V411_splice|MACROD2_ENST00000378058.3_Splice_Site_p.V176_splice|MACROD2_ENST00000402914.1_Splice_Site_p.V176_splice|MACROD2_ENST00000407045.3_Splice_Site_p.V62_splice	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	434										breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				AGGTCCTGATGGTAAGGTTCT	0.443000													18	26					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129419523	129419523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:129419523C>T	ENST00000421865.2	+	4	651	c.602C>T	c.(601-603)tCa>tTa	p.S201L		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	201	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATCTGCACTTCATTTTACTCC	0.433000													38	46					0	0	1	0	0
NR4A1	3164	broad.mit.edu	37	12	52451249	52451249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52451249C>T	ENST00000545748.1	+	7	2632	c.1637C>T	c.(1636-1638)tCc>tTc	p.S546F	NR4A1_ENST00000394824.2_Missense_Mutation_p.S492F|NR4A1_ENST00000243050.1_Missense_Mutation_p.S492F|NR4A1_ENST00000360284.3_Missense_Mutation_p.S505F|NR4A1_ENST00000550082.1_Missense_Mutation_p.S505F|NR4A1_ENST00000394825.1_Missense_Mutation_p.S492F			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	492					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		TTCTCAAGGTCCCTGCACAGC	0.602000													10	58					0	0	1	0	0
RHOT1	55288	broad.mit.edu	37	17	30503006	30503006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:30503006C>T	ENST00000358365.3	+	5	475	c.248C>T	c.(247-249)gCc>gTc	p.A83V	RHOT1_ENST00000333942.6_Missense_Mutation_p.A83V|RHOT1_ENST00000580976.1_Intron|RHOT1_ENST00000581094.1_Missense_Mutation_p.A83V|RHOT1_ENST00000583994.1_5'UTR|RHOT1_ENST00000545287.2_Missense_Mutation_p.A83V|RHOT1_ENST00000354266.3_Missense_Mutation_p.A62V|RHOT1_ENST00000394692.2_Missense_Mutation_p.A83V	NM_001033568.1	NP_001028740.1	Q8IXI2	MIRO1_HUMAN	ras homolog family member T1	83	Miro 1.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			NS(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				ATAGTGTATGCCGTTAACAAC	0.308000													7	25					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181708304	181708304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181708304C>T	ENST00000526775.1	+	24	3742	c.3577C>T	c.(3577-3579)Ctg>Ttg	p.L1193L	CACNA1E_ENST00000367570.1_Silent_p.L1212L|CACNA1E_ENST00000367567.4_Silent_p.L819L|CACNA1E_ENST00000360108.3_Silent_p.L1193L|CACNA1E_ENST00000357570.5_Silent_p.L1163L|CACNA1E_ENST00000358338.5_Silent_p.L1144L|CACNA1E_ENST00000367573.2_Silent_p.L1212L	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1212					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGGCTTGATCCTGCAGGATGG	0.512000													46	130					0	0	1	0	0
STX5	6811	broad.mit.edu	37	11	62574950	62574950	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62574950G>A	ENST00000294179.3	-	11	1212	c.1059C>T	c.(1057-1059)ttC>ttT	p.F353F	STX5_ENST00000541317.1_Silent_p.F257F|STX5_ENST00000377897.4_3'UTR|STX5_ENST00000394690.1_Silent_p.F299F	NM_001244666.1|NM_003164.4	NP_001231595.1|NP_003155.2	Q13190	STX5_HUMAN	syntaxin 5	353					intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			breast(2)|endometrium(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	18						TTCAAGCAAGGAAGACCACAA	0.527000													5	29					0	0	1	0	0
DPYSL3	1809	broad.mit.edu	37	5	146780333	146780333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:146780333C>T	ENST00000343218.5	-	10	1571	c.1374G>A	c.(1372-1374)ggG>ggA	p.G458G	DPYSL3_ENST00000534907.1_Intron|DPYSL3_ENST00000398514.3_Silent_p.G344G	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	344					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGTCCTTCCCAATTGCTT	0.557000													20	55					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288831	107288831	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107288831G>A	ENST00000277216.3	-	1	659	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TGTAGAGGATGAACATATAGG	0.408000													21	109					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36330510	36330510	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36330510C>T	ENST00000378910.5	-	21	2815		c.e21-1		NPHS1_ENST00000353632.6_Splice_Site	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)						cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCAGGGCGGCCTATGGGGAGA	0.502000													17	70					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161821579	161821579	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161821579C>T	ENST00000367942.3	+	11	1454	c.1387C>T	c.(1387-1389)Cct>Tct	p.P463S	ATF6_ENST00000476437.1_3'UTR	NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	463	Poly-Pro.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GCTTTACATTCCTCCACCTCC	0.398000													77	200					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23065576	23065576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23065576G>A	ENST00000246006.4	-	1	1401	c.1254C>T	c.(1252-1254)gcC>gcT	p.A418A		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	418	EGF-like 4; calcium-binding (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGTCCTCCCCGGCCAGGACGT	0.632000													35	64					0	0	1	0	0
KRT17	3872	broad.mit.edu	37	17	39780712	39780712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39780712G>A	ENST00000311208.8	-	1	117	c.50C>T	c.(49-51)tCc>tTc	p.S17F	JUP_ENST00000540235.1_Intron	NM_000422.2	NP_000413.1	Q04695	K1C17_HUMAN	keratin 17	17	Head.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	12		Breast(137;0.000307)				CAGGCCGGAGGAGCCCTTGAT	0.716000													9	13					0	0	1	0	0
CCT3	7203	broad.mit.edu	37	1	156294849	156294849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156294849G>A	ENST00000295688.3	-	6	616	c.336C>T	c.(334-336)ttC>ttT	p.F112F	CCT3_ENST00000368261.3_Silent_p.F67F|CCT3_ENST00000368259.2_Silent_p.F74F|CCT3_ENST00000472765.2_Silent_p.F67F	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	112					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					GCTGCTCCAGGAAGTGCTCAG	0.428000													15	69					0	0	1	0	0
CDH1	999	broad.mit.edu	37	16	68842665	68842665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68842665C>T	ENST00000261769.5	+	5	792	c.601C>T	c.(601-603)Cct>Tct	p.P201S	CDH1_ENST00000422392.2_Missense_Mutation_p.P201S|CDH1_ENST00000562836.1_3'UTR	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	201	Cadherin 1.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(2)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TGACACACCCCCTGTTGGTGT	0.413000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				16	49					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	43990966	43990966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43990966G>A	ENST00000292140.5	-	11	1666	c.1306C>T	c.(1306-1308)Ctc>Ttc	p.L436F		NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	436										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				AGCTGGTAGAGGGGGTATCTG	0.612000													3	19					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56345178	56345178	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56345178G>A	ENST00000262290.4	+	13	2278	c.1962G>A	c.(1960-1962)acG>acA	p.T654T	LPO_ENST00000421678.2_Silent_p.T571T|LPO_ENST00000543544.1_Silent_p.T595T|LPO_ENST00000582328.1_Silent_p.T571T	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	654					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						GGGTCTTCACGAACGAGCAGA	0.572000													21	50					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38990427	38990427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:38990427C>T	ENST00000318792.1	+	2	231	c.221C>T	c.(220-222)tCc>tTc	p.S74F		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	74										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		GAAGATGCTTCCCTTCTCTTC	0.507000													20	50					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42858582	42858582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:42858582G>A	ENST00000455697.1	-	7	1539	c.1254C>T	c.(1252-1254)ctC>ctT	p.L418L	RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000445766.2_Silent_p.L418L|PRICKLE1_ENST00000552240.1_Silent_p.L418L|PRICKLE1_ENST00000548696.1_Silent_p.L418L|PRICKLE1_ENST00000345127.3_Silent_p.L418L	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	418					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		ACTTGAGGAGGAGCTGCGTCA	0.438000													6	38					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197073649	197073649	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197073649G>A	ENST00000367409.4	-	18	4988	c.4732C>T	c.(4732-4734)Cga>Tga	p.R1578*	ASPM_ENST00000294732.7_Intron|ASPM_ENST00000367408.1_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1578					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TTTAAAAATCGAACTCTGTCT	0.338000													19	72					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41062005	41062005	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41062005G>A	ENST00000352632.3	+	25	5186	c.5100G>A	c.(5098-5100)cgG>cgA	p.R1700R	SPTBN4_ENST00000392025.1_Silent_p.R443R|SPTBN4_ENST00000598249.1_Silent_p.R1700R|SPTBN4_ENST00000392023.1_Silent_p.R376R|SPTBN4_ENST00000595535.1_Silent_p.R1700R|SPTBN4_ENST00000338932.3_Silent_p.R1700R			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1700					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGATCAGCCGGCGGCAGTCTC	0.662000													4	23					0	0	1	0	0
KLHL38	340359	broad.mit.edu	37	8	124664732	124664732	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124664732G>A	ENST00000325995.7	-	1	458	c.435C>T	c.(433-435)atC>atT	p.I145I	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	145	BACK.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						CGCAGCTTAAGATTTCTGAGA	0.582000													20	51					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25890625	25890625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:25890625G>A	ENST00000520164.1	-	6	1064	c.527C>T	c.(526-528)cCa>cTa	p.P176L	EBF2_ENST00000408929.3_Missense_Mutation_p.P28L	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	176					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TGGGTCCGATGGAGTCTCATT	0.388000													8	120					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101835746	101835746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101835746G>A	ENST00000370418.3	-	2	593	c.342C>T	c.(340-342)atC>atT	p.I114I		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	114	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TGAGCTGGACGATGCGCTGGT	0.612000													24	66					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6260441	6260441	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6260441G>A	ENST00000379936.2	+	1	120	c.5G>A	c.(4-6)aGc>aAc	p.S2N	CNGA4_ENST00000533426.1_Intron	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	2					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAACCATGAGCCAGGACACC	0.577000													27	65					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77290690	77290690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77290690G>A	ENST00000388914.3	-	10	1388	c.1236C>T	c.(1234-1236)atC>atT	p.I412I		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	412										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						GGTCAATGGTGATGCTGTTGC	0.557000													6	84					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25671151	25671151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25671151G>A	ENST00000281589.3	+	1	852	c.815G>A	c.(814-816)cGg>cAg	p.R272Q		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	272					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding	p.R272Q(1)		breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAAGTGGAACGGCAGACGGAA	0.398000													49	136					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59221482	59221482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:59221482G>A	ENST00000262717.4	+	12	2358	c.1960G>A	c.(1960-1962)Gac>Aac	p.D654N	CDH20_ENST00000536675.2_Missense_Mutation_p.D654N|CDH20_ENST00000538374.1_Missense_Mutation_p.D654N			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	654					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				CATCATCGACGACGAGGAAAA	0.577000													47	147					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8007490	8007490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8007490G>A	ENST00000380149.1	-	13	2226	c.2196C>T	c.(2194-2196)ttC>ttT	p.F732F	ALOXE3_ENST00000448843.2_Silent_p.F576F|ALOXE3_ENST00000318227.3_Silent_p.F708F			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	576					leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						TTGCAGTGAGGAACTTCACCA	0.582000													11	17					0	0	1	0	0
OSR2	116039	broad.mit.edu	37	8	99961684	99961684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:99961684G>A	ENST00000297565.4	+	2	1000	c.504G>A	c.(502-504)acG>acA	p.T168T	OSR2_ENST00000435298.2_Silent_p.T168T|OSR2_ENST00000522510.1_Silent_p.T168T|OSR2_ENST00000523368.1_Silent_p.T168T|OSR2_ENST00000457907.2_Silent_p.T289T	NM_001142462.1	NP_001135934.1	Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	168					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CCTCCAAAACGAAAAAAGAGT	0.522000													73	232					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57407426	57407426	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:57407426C>A	ENST00000374900.4	+	7	1080	c.960C>A	c.(958-960)tcC>tcA	p.S320S		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	320						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						TTTTAATGTCCAAAGTGGACC	0.303000										HNSCC(52;0.14)			49	26					3.39706e-21	3.41802e-21	1	1	0
ZNF615	284370	broad.mit.edu	37	19	52497354	52497354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52497354G>A	ENST00000602063.1	-	6	1324	c.975C>T	c.(973-975)ttC>ttT	p.F325F	ZNF615_ENST00000376716.5_Silent_p.F325F|ZNF615_ENST00000594083.1_Silent_p.F336F|ZNF615_ENST00000598071.1_Silent_p.F336F|ZNF615_ENST00000391795.3_Silent_p.F330F			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		ACTTTGTAGAGAAGGCCTTCC	0.423000													18	163					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87614323	87614323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87614323G>A	ENST00000327946.7	-	8	1248	c.1163C>T	c.(1162-1164)tCg>tTg	p.S388L		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	388						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	ATAGGGATTCGAACTGTCCTC	0.493000										Multiple Myeloma(13;0.14)			27	64					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196774900	196774900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196774900G>A	ENST00000312428.6	-	25	4055	c.3955C>T	c.(3955-3957)Cat>Tat	p.H1319Y		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1319	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGGTGCAAATGAAGGGCTCCA	0.398000													9	25					0	0	1	0	0
EXD3	54932	broad.mit.edu	37	9	140267448	140267448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140267448G>A	ENST00000340951.4	-	5	566	c.371C>T	c.(370-372)cCa>cTa	p.P124L	EXD3_ENST00000342129.4_5'UTR|EXD3_ENST00000475006.1_5'UTR|EXD3_ENST00000479452.1_Missense_Mutation_p.P124L	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	124					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						GCTGGCCAGTGGTGCCGCAAG	0.642000													11	57					0	0	1	0	0
MVB12B	89853	broad.mit.edu	37	9	129143376	129143376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:129143376C>T	ENST00000361171.3	+	3	319	c.238C>T	c.(238-240)Ctc>Ttc	p.L80F	MVB12B_ENST00000535766.1_Missense_Mutation_p.L73F|MVB12B_ENST00000436593.3_Missense_Mutation_p.L65F|MVB12B_ENST00000545391.1_Missense_Mutation_p.L80F	NM_033446.2	NP_258257.1			multivesicular body subunit 12B																		GGATGCTGACCTCTGGAAAGA	0.463000													37	63					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4947743	4947743	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4947743C>T	ENST00000345988.2	-	9	994	c.905G>A	c.(904-906)tGg>tAg	p.W302*	PPL_ENST00000590782.2_Nonsense_Mutation_p.W300*	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	302					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GTACTCCTTCCAGTCTGCGTG	0.602000													18	29					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20129011	20129011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20129011C>T	ENST00000334554.7	+	9	1224	c.1083C>T	c.(1081-1083)ttC>ttT	p.F361F	ZDHHC8_ENST00000320602.7_Silent_p.F269F|ZDHHC8_ENST00000405930.3_Silent_p.F361F|ZDHHC8_ENST00000468112.1_3'UTR	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	361						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					GGCCGGCTTTCCCCACGGGTC	0.657000													9	31					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156875149	156875149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156875149G>A	ENST00000338302.3	+	5	465	c.240G>A	c.(238-240)gtG>gtA	p.V80V	PEAR1_ENST00000292357.7_Silent_p.V80V			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	80	EMI.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTCAGGTGGTGAAGACGGACC	0.657000													8	38					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94316839	94316839	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94316839C>T	ENST00000282020.4	+	9	1585	c.1327C>T	c.(1327-1329)Cta>Tta	p.L443L	GRID2_ENST00000510992.1_Silent_p.L348L	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	443					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGGAGTGGTTCTACGTGTAGT	0.393000													33	84					0	0	1	0	0
PTGFR	5737	broad.mit.edu	37	1	78959016	78959016	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:78959016G>A	ENST00000370756.3	+	2	825	c.588G>A	c.(586-588)tgG>tgA	p.W196*	PTGFR_ENST00000370758.1_Nonsense_Mutation_p.W196*|PTGFR_ENST00000370757.3_Nonsense_Mutation_p.W196*	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	196					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	TCAAAGACTGGGAAGATAGAT	0.408000													11	114					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229771485	229771485	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:229771485C>T	ENST00000258243.2	+	4	1261	c.1125C>T	c.(1123-1125)atC>atT	p.I375I		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	375						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						TCTACAACATCGCTGCCGACA	0.522000													25	49					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32486707	32486707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:32486707C>T	ENST00000357033.4	-	23	3276	c.3070G>A	c.(3070-3072)Gaa>Aaa	p.E1024K	DMD_ENST00000378677.2_Missense_Mutation_p.E1020K	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1024					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCCTCAATTTCTTCAAATTCT	0.428000													18	11					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169049242	169049242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169049242G>A	ENST00000359299.3	+	2	212	c.26G>A	c.(25-27)gGa>gAa	p.G9E		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	9							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		CAGGTGCAAGGAACCATCTTC	0.423000													28	36					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182156	140182156	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140182156C>T	ENST00000522353.2	+	1	1374	c.1374C>T	c.(1372-1374)tcC>tcT	p.S458S	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Silent_p.S458S|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCGCAGTCCGAGTACACGG	0.667000													51	115					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110494919	110494919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:110494919C>T	ENST00000324068.1	-	6	918	c.751G>A	c.(751-753)Ggc>Agc	p.G251S	CAPN6_ENST00000541758.1_5'UTR	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	251	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						TAGGTATGGCCCTTCAGCAGA	0.448000													141	110					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	77134191	77134191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77134191G>A	ENST00000563290.1	-	5	372	c.277C>T	c.(277-279)Cct>Tct	p.P93S	SCAPER_ENST00000324767.7_Missense_Mutation_p.P93S|SCAPER_ENST00000538941.2_5'UTR			Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	92						endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						ATTTTCCGAGGGTGCCTTGTT	0.388000													10	132					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84777114	84777114	+	Missense_Mutation	SNP	G	G	A	rs148362906	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:84777114G>A	ENST00000389394.3	+	9	1555	c.1418G>A	c.(1417-1419)cGa>cAa	p.R473Q	DNAH6_ENST00000237449.6_Missense_Mutation_p.R473Q|DNAH6_ENST00000398278.2_Missense_Mutation_p.R473Q	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	473	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						AAGCTAAAACGAACACCTTCA	0.348000													15	40					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16907974	16907974	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16907974A>T	ENST00000430580.2	-	15	2207	c.1320T>A	c.(1318-1320)gaT>gaA	p.D440E		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	440	NBPF 2.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CTTCATCCTCATCTTCGTCAT	0.433000													36	966					0	0	1	0	0
NRIP2	83714	broad.mit.edu	37	12	2936434	2936434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2936434C>T	ENST00000337508.4	-	6	825	c.785G>A	c.(784-786)cGg>cAg	p.R262Q	ITFG2_ENST00000542548.1_Intron	NM_031474.2	NP_113662.1	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	262					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GGCTTTCAGCCGCAGCACTCC	0.622000													12	24					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3677394	3677394	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3677394C>T	ENST00000344754.4	-	10	2521	c.2522G>A	c.(2521-2523)gGt>gAt	p.G841D	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.G841D	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	841	Ig-like C2-type 8.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GACCTGGGGACCCAGGCTGGT	0.637000													13	64					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157509152	157509152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157509152G>A	ENST00000361835.3	-	7	1283	c.1126C>T	c.(1126-1128)Ccc>Tcc	p.P376S	FCRL5_ENST00000368189.3_Missense_Mutation_p.P376S|FCRL5_ENST00000368190.3_Missense_Mutation_p.P376S|FCRL5_ENST00000356953.4_Missense_Mutation_p.P376S|FCRL5_ENST00000368191.3_Missense_Mutation_p.P291S	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	376						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TGAGACACGGGAACTGAGAGA	0.458000													13	43					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43936053	43936053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43936053G>A	ENST00000262726.7	-	28	4086	c.3833C>T	c.(3832-3834)cCc>cTc	p.P1278L	EFCAB6_ENST00000461800.1_5'UTR|EFCAB6_ENST00000396231.2_Missense_Mutation_p.P1126L	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CTCCTGAGTGGGCAATGAGAG	0.612000													6	72					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480454	73480454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73480454G>A	ENST00000523207.1	+	2	1073	c.485G>A	c.(484-486)cGa>cAa	p.R162Q		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	162				ER -> DG (in Ref. 1; AAP46292).	regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding	p.R162Q(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			ATGCGAGAGCGAGAAGGAGAA	0.458000													9	169					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767669	57767669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57767669C>T	ENST00000371030.2	+	1	1595	c.1595C>T	c.(1594-1596)cCt>cTt	p.P532L		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	532						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					ACGCAGAAGCCTCTGAGCCCC	0.721000													4	4					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121971092	121971092	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:121971092C>T	ENST00000265922.3	-	7	1511	c.1050G>A	c.(1048-1050)gaG>gaA	p.E350E	DBC1_ENST00000482797.1_5'UTR	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		350					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GTCTCTGTGCCTCCGTGGCAC	0.577000													17	48					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111143688	111143688	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111143688G>A	ENST00000360467.5	+	37	3760		c.e37+1			NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2						angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGACAAACAGGTAAAATCTCC	0.542000													3	4					0	0	1	0	0
YTHDF1	54915	broad.mit.edu	37	20	61834443	61834443	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61834443G>A	ENST00000370339.3	-	4	1190	c.849C>T	c.(847-849)gcC>gcT	p.A283A	YTHDF1_ENST00000370334.4_Intron|YTHDF1_ENST00000370333.4_Silent_p.A233A	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	283	Gln/Pro-rich.			AP -> PH (in Ref. 5; CAD39029).						NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						GGGGGACTGGGGCCTTCGGCA	0.652000													36	100					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54147437	54147437	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:54147437C>T	ENST00000265572.3	-	3	789	c.492G>A	c.(490-492)gtG>gtA	p.V164V	RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000524278.1_Silent_p.V75V|OPRK1_ENST00000520287.1_Silent_p.V164V	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	164					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CCAAAGCCTTCACGGGGTGGC	0.488000													14	68					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67161070	67161070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:67161070C>T	ENST00000435165.2	+	1	694	c.39C>T	c.(37-39)ctC>ctT	p.L13L	SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371037.4_Intron|SGIP1_ENST00000371036.3_Intron|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000237247.6_Intron			Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	509					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CCTTCTCTCTCCCTTTCCTTA	0.468000													6	60					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20576124	20576124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20576124C>T	ENST00000329697.6	-	2	212	c.44G>A	c.(43-45)gGt>gAt	p.G15D	ACSM2B_ENST00000565322.1_Intron|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G15D|ACSM2B_ENST00000414188.2_Missense_Mutation_p.G15D|ACSM2B_ENST00000565232.1_Missense_Mutation_p.G15D	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	15					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CATCTGAGTACCCCACAGGGT	0.493000													16	55					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69002342	69002342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69002342C>T	ENST00000409220.1	+	1	410	c.30C>T	c.(28-30)ttC>ttT	p.F10F	ARHGAP25_ENST00000497079.1_Silent_p.F10F|ARHGAP25_ENST00000544262.1_Intron|ARHGAP25_ENST00000467265.1_Intron|ARHGAP25_ENST00000456116.2_Intron|ARHGAP25_ENST00000409030.3_Silent_p.F10F|ARHGAP25_ENST00000409202.3_Intron|ARHGAP25_ENST00000295381.3_Intron	NM_001166276.1	NP_001159748.1	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	0					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CCTGTCTGTTCCTCTCTATAG	0.622000													115	277					0	0	1	0	0
DIS3	22894	broad.mit.edu	37	13	73346025	73346025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:73346025G>A	ENST00000377767.4	-	11	1613	c.1513C>T	c.(1513-1515)Cat>Tat	p.H505Y	DIS3_ENST00000377780.4_Missense_Mutation_p.H475Y|DIS3_ENST00000545453.1_Missense_Mutation_p.H343Y	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	505					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TCAGCAATATGAACACCAACC	0.333000										Multiple Myeloma(4;0.011)			22	104					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072297	134072297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:134072297C>T	ENST00000264360.4	+	1	1828	c.1002C>T	c.(1000-1002)ggC>ggT	p.G334G		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	334	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		AGGACCTGGGCCCCAACGCCG	0.597000													20	121					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102956585	102956585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102956585G>A	ENST00000311734.2	+	4	639	c.300G>A	c.(298-300)gcG>gcA	p.A100A	IL1RL1_ENST00000473175.1_3'UTR|IL1RL1_ENST00000404917.2_5'UTR|IL1RL1_ENST00000233954.1_Silent_p.A100A|IL1RL1_ENST00000393393.3_Silent_p.A100A|IL1RL1_ENST00000409584.1_Silent_p.A100A			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	100	Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						CTGGATATGCGAATGTCACCA	0.299000													7	30					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228509866	228509866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228509866C>T	ENST00000570156.2	+	66	18269	c.18195C>T	c.(18193-18195)gcC>gcT	p.A6065A	OBSCN_ENST00000366707.4_Silent_p.A2742A|OBSCN_ENST00000422127.1_Silent_p.A5108A|OBSCN_ENST00000284548.11_Silent_p.A5108A|OBSCN_ENST00000366709.4_Silent_p.A2227A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5108	Ig-like 52.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGACTCCTGCCCCTGTGGTGC	0.602000													10	19					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72129198	72129198	+	Splice_Site	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:72129198A>T	ENST00000340726.3	-	13	1839		c.e13+1		EYA1_ENST00000388742.4_Splice_Site|EYA1_ENST00000388741.2_Splice_Site|EYA1_ENST00000303824.7_Splice_Site|EYA1_ENST00000419131.1_Splice_Site|EYA1_ENST00000388743.2_Splice_Site|EYA1_ENST00000388740.3_Splice_Site	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)						double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AAGGGTGCTCACCTTAGGTCC	0.358000													32	80					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6483972	6483972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6483972C>T	ENST00000263125.5	-	16	1818	c.1719G>A	c.(1717-1719)ctG>ctA	p.L573L	PRKCQ_ENST00000539722.1_Silent_p.L448L|PRKCQ_ENST00000397176.2_Intron	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	573	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						ACTGACCAATCAGCATTTCAT	0.517000													29	67					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58966695	58966695	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58966695C>T	ENST00000391696.1	+	3	1286	c.354C>T	c.(352-354)gcC>gcT	p.A118A	ZNF324B_ENST00000336614.4_Silent_p.A128A|ZNF324B_ENST00000545523.1_Silent_p.A128A			Q6AW86	Z324B_HUMAN	zinc finger protein 324B	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AACCGGGTGCCTCCCCATCTC	0.607000													35	87					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228480406	228480406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228480406C>T	ENST00000570156.2	+	45	12147	c.12073C>T	c.(12073-12075)Cgt>Tgt	p.R4025C	OBSCN_ENST00000366707.4_Missense_Mutation_p.R715C|OBSCN_ENST00000422127.1_Missense_Mutation_p.R3596C|OBSCN_ENST00000284548.11_Missense_Mutation_p.R3596C|OBSCN_ENST00000366709.4_Missense_Mutation_p.R715C|OBSCN_ENST00000359599.6_Missense_Mutation_p.R2443C	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3066	Ig-like 41.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCTGCAGATTCGTGGCCTGGC	0.602000													53	127					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81065942	81065942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81065942C>T	ENST00000334512.5	+	22	3081	c.2509C>T	c.(2509-2511)Cct>Tct	p.P837S		NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	837					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CAAGGACGACCCTGATGGCAT	0.612000													18	41					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43708292	43708292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43708292G>A	ENST00000405312.3	-	2	413	c.176C>T	c.(175-177)cCc>cTc	p.P59L	PSG4_ENST00000433626.2_Missense_Mutation_p.P59L|PSG4_ENST00000244295.9_Missense_Mutation_p.P59L	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	59	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				AAGATTCTGGGGCAAATTGTG	0.443000													30	347					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152818521	152818521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:152818521G>A	ENST00000370186.1	+	11	2136	c.1810G>A	c.(1810-1812)Gaa>Aaa	p.E604K	ATP2B3_ENST00000263519.4_Missense_Mutation_p.E618K|ATP2B3_ENST00000393842.1_Missense_Mutation_p.E604K|ATP2B3_ENST00000349466.2_Missense_Mutation_p.E618K|ATP2B3_ENST00000370181.2_Missense_Mutation_p.E604K|ATP2B3_ENST00000359149.3_Missense_Mutation_p.E618K			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	618					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCAATGGCGAACTCCGGGG	0.612000													23	13					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059682	152059682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152059682G>A	ENST00000368806.1	-	3	540	c.476C>T	c.(475-477)cCa>cTa	p.P159L		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	159							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTCTCTCCATGGGTCCACTCT	0.453000													16	100					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89537460	89537460	+	Missense_Mutation	SNP	C	C	T	rs141552770		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:89537460C>T	ENST00000329758.1	-	3	506	c.178G>A	c.(178-180)Gag>Aag	p.E60K	TRIM49_ENST00000532501.2_Missense_Mutation_p.E60K	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	60						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTTATCTGCTCGGTTGACTTT	0.463000													25	97					0	0	1	0	0
PLD4	122618	broad.mit.edu	37	14	105398476	105398476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105398476G>A	ENST00000540372.1	+	9	1399	c.1207G>A	c.(1207-1209)Gcg>Acg	p.A403T	PLD4_ENST00000392593.4_Missense_Mutation_p.A396T			Q96BZ4	PLD4_HUMAN	phospholipase D family, member 4	396					lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	13		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	GTCCCTGCAGGCGCTCAGCAA	0.731000													7	22					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70924606	70924606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70924606G>A	ENST00000603540.1	+	2	648	c.390G>A	c.(388-390)ggG>ggA	p.G130G	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Silent_p.G130G	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	130					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CTTGTTTTGGGGGCTTTCGAG	0.453000													39	109					0	0	1	0	0
ZNF512B	57473	broad.mit.edu	37	20	62598022	62598022	+	Missense_Mutation	SNP	G	G	A	rs140764494	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62598022G>A	ENST00000450537.1	-	5	566	c.506C>T	c.(505-507)cCt>cTt	p.P169L	ZNF512B_ENST00000369888.1_Missense_Mutation_p.P169L|ZNF512B_ENST00000217130.3_Missense_Mutation_p.P169L			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CTTGGAGGCAGGCAGGGGTCG	0.622000													22	79					0	0	1	0	0
TMEM156	80008	broad.mit.edu	37	4	39000451	39000451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39000451G>A	ENST00000381938.3	-	2	274	c.167C>T	c.(166-168)tCt>tTt	p.S56F	TMEM156_ENST00000372489.2_5'UTR	NM_024943.1	NP_079219.1	Q8N614	TM156_HUMAN	transmembrane protein 156	56						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						AGTCACAAAAGAAAAATTTAA	0.353000													17	32					0	0	1	0	0
TUBA4A	7277	broad.mit.edu	37	2	220116411	220116411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220116411C>T	ENST00000392088.2	-	3	761	c.206G>A	c.(205-207)cGa>cAa	p.R69Q	TUBA4A_ENST00000498660.1_5'UTR|TUBA4A_ENST00000248437.4_Missense_Mutation_p.R84Q	NM_001278552.1	NP_001265481.1	P68366	TBA4A_HUMAN	tubulin, alpha 4a	84					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAAGAGCTGTCGGTATGGGCC	0.542000													27	39					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603793	5603793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5603793G>A	ENST00000423158.3	+	2	664	c.452G>A	c.(451-453)cGg>cAg	p.R151Q	NTF3_ENST00000331010.6_Missense_Mutation_p.R138Q|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	138					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding	p.R138Q(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						CGGCGGAAACGGTACGCGGAG	0.602000													33	66					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100190865	100190865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:100190865C>T	ENST00000355295.4	+	2	413	c.118C>T	c.(118-120)Ccc>Tcc	p.P40S	TDRD7_ENST00000422139.2_Intron	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	40	Lotus/OST-HTH 1.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				AGACTGGATCCCCTTCAAACA	0.483000													17	61					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631951	32631951	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32631951G>A	ENST00000242310.4	-	1	3716	c.3627C>T	c.(3625-3627)gtC>gtT	p.V1209V		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1209					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGGCATCAATGACAGCTGGTT	0.428000													61	96					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27419836	27419836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:27419836G>A	ENST00000211936.6	-	6	1786	c.1502C>T	c.(1501-1503)cCc>cTc	p.P501L	ZNF184_ENST00000377419.1_Missense_Mutation_p.P501L	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						GCATTCAAAGGGCTTTTCTCT	0.388000													19	81					0	0	1	0	0
ZNF358	140467	broad.mit.edu	37	19	7584262	7584262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7584262C>T	ENST00000597229.1	+	2	304	c.134C>T	c.(133-135)cCt>cTt	p.P45L	ZNF358_ENST00000394341.2_Missense_Mutation_p.P45L|CTD-2207O23.12_ENST00000599312.1_3'UTR	NM_018083.4	NP_060553.4	Q9NW07	ZN358_HUMAN	zinc finger protein 358	45					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|lung(1)|skin(2)	8						GACCCAGAGCCTGATCCTGAA	0.582000													36	73					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43897964	43897964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43897964C>T	ENST00000562955.1	+	36	5125	c.5125C>T	c.(5125-5127)Cct>Tct	p.P1709S	SZT2_ENST00000372442.1_Missense_Mutation_p.P867S	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1766						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CCTCCATCTCCCTGGCCATGT	0.577000													113	303					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41615664	41615664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41615664G>A	ENST00000313860.7	+	7	722	c.668G>A	c.(667-669)aGg>aAg	p.R223K	LIMCH1_ENST00000513024.1_Missense_Mutation_p.R64K|LIMCH1_ENST00000396595.3_Missense_Mutation_p.R69K|LIMCH1_ENST00000381753.4_Missense_Mutation_p.R69K|LIMCH1_ENST00000512946.1_Missense_Mutation_p.R223K|LIMCH1_ENST00000514096.1_Missense_Mutation_p.R76K|LIMCH1_ENST00000509454.1_Missense_Mutation_p.R71K|LIMCH1_ENST00000509277.1_Missense_Mutation_p.R69K|LIMCH1_ENST00000512820.1_Missense_Mutation_p.R223K|LIMCH1_ENST00000508501.1_Missense_Mutation_p.R223K|LIMCH1_ENST00000509638.1_Missense_Mutation_p.R64K|LIMCH1_ENST00000503057.1_Missense_Mutation_p.R64K|LIMCH1_ENST00000512632.1_Missense_Mutation_p.R223K|LIMCH1_ENST00000511496.1_Missense_Mutation_p.R64K	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	223					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						GTAGTCCTCAGGGGAAGCAGC	0.542000													9	64					0	0	1	0	0
ZNF662	389114	broad.mit.edu	37	3	42956099	42956099	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42956099C>T	ENST00000541208.1	+	5	903	c.534C>T	c.(532-534)ctC>ctT	p.L178L	ZNF662_ENST00000440367.2_Silent_p.L178L|ZNF662_ENST00000422021.1_Intron|ZNF662_ENST00000328199.6_Silent_p.L204L|KRBOX1_ENST00000426937.1_Intron			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		TCAATAACCTCCTTGGTATAC	0.353000													29	71					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228486318	228486318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228486318G>A	ENST00000570156.2	+	49	13184	c.13110G>A	c.(13108-13110)acG>acA	p.T4370T	RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000366707.4_Silent_p.T1060T|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000359599.6_3'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3413	Ig-like 45.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGATGGGACGAGGTGTGAGC	0.587000													32	75					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8181592	8181592	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8181592G>A	ENST00000600128.1	-	29	4092	c.3678C>T	c.(3676-3678)ggC>ggT	p.G1226G	FBN3_ENST00000601739.1_Silent_p.G1226G|FBN3_ENST00000270509.2_Silent_p.G1226G			Q75N90	FBN3_HUMAN	fibrillin 3	1226	EGF-like 17.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGGCCATGAAGCCATCATAGC	0.627000													14	109					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736825	140736825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140736825C>T	ENST00000571252.1	+	1	2058	c.2058C>T	c.(2056-2058)gaC>gaT	p.D686D	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCCAGACGACTCGGGCCTCA	0.617000													26	49					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940459	144940459	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144940459G>A	ENST00000525985.1	-	2	7034	c.6963C>T	c.(6961-6963)ctC>ctT	p.L2321L				P58107	EPIPL_HUMAN	epiplakin 1	2321						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGCCTGGAAGAGGGAGATCT	0.706000													17	335					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7561562	7561562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:7561562C>T	ENST00000399429.3	-	5	873	c.733G>A	c.(733-735)Gga>Aga	p.G245R		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	245	Collagen-like 1.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CCTGGATCTCCCTTCTCACAT	0.378000													18	58					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48652918	48652918	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48652918C>T	ENST00000352832.5	+	8	1527	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	CACNA1G_ENST00000514717.1_Silent_p.F385F|CACNA1G_ENST00000515765.1_Silent_p.F385F|CACNA1G_ENST00000510366.1_Silent_p.F385F|CACNA1G_ENST00000512389.1_Silent_p.F385F|CACNA1G_ENST00000513964.1_Silent_p.F385F|CACNA1G_ENST00000513689.2_Silent_p.F385F|CACNA1G_ENST00000507609.1_Silent_p.F385F|CACNA1G_ENST00000505165.1_Silent_p.F385F|CACNA1G_ENST00000507336.1_Silent_p.F385F|CACNA1G_ENST00000507510.2_Silent_p.F385F|CACNA1G_ENST00000442258.2_Silent_p.F385F|CACNA1G_ENST00000514181.1_Silent_p.F385F|CACNA1G_ENST00000429973.2_Silent_p.F385F|CACNA1G_ENST00000514079.1_Silent_p.F385F|CACNA1G_ENST00000515165.1_Silent_p.F385F|CACNA1G_ENST00000510115.1_Silent_p.F385F|CACNA1G_ENST00000503485.1_Silent_p.F385F|CACNA1G_ENST00000358244.5_Silent_p.F385F|CACNA1G_ENST00000502264.1_Silent_p.F385F|CACNA1G_ENST00000416767.4_Silent_p.F385F|CACNA1G_ENST00000359106.5_Silent_p.F385F|CACNA1G_ENST00000354983.4_Silent_p.F385F|CACNA1G_ENST00000507896.1_Silent_p.F385F|CACNA1G_ENST00000515411.1_Silent_p.F385F|CACNA1G_ENST00000360761.4_Silent_p.F385F	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	385					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCTCCTTCTTCATGATCAACC	0.552000													13	26					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100402849	100402849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100402849C>T	ENST00000358173.3	-	16	3241	c.2773G>A	c.(2773-2775)Gaa>Aaa	p.E925K	EPHB4_ENST00000360620.3_Intron	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	925	SAM.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					AAACTTTCTTCGTATCTTCCC	0.602000													4	16					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39564382	39564382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39564382C>T	ENST00000265707.5	+	18	2021	c.1976C>T	c.(1975-1977)tCc>tTc	p.S659F	ADAM18_ENST00000523755.1_3'UTR|ADAM18_ENST00000541111.1_Missense_Mutation_p.S73F|ADAM18_ENST00000379866.1_Missense_Mutation_p.S635F	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	659					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CAGTTTGGTTCCCCAGGGGGT	0.318000													10	64					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123846092	123846092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123846092G>A	ENST00000369005.1	+	4	4417	c.4077G>A	c.(4075-4077)ggG>ggA	p.G1359G	TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Silent_p.G1359G|TACC2_ENST00000334433.3_Silent_p.G1359G|TACC2_ENST00000515273.1_Silent_p.G1359G|TACC2_ENST00000453444.2_Silent_p.G1359G	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1359						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGGCCAGTGGGGAGGGCATGG	0.622000													18	35					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36939451	36939451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36939451C>T	ENST00000373103.1	-	5	946	c.399G>A	c.(397-399)atG>atA	p.M133I	CSF3R_ENST00000338937.5_Missense_Mutation_p.M133I|CSF3R_ENST00000373106.1_Missense_Mutation_p.M133I|CSF3R_ENST00000361632.4_Missense_Mutation_p.M133I|CSF3R_ENST00000373104.1_Missense_Mutation_p.M133I|CSF3R_ENST00000440588.2_Missense_Mutation_p.M133I|CSF3R_ENST00000418048.2_Missense_Mutation_p.M133I|CSF3R_ENST00000331941.5_Missense_Mutation_p.M133I	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	133	Fibronectin type-III 1.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTGTGAGGTTCATGAGGCAGG	0.592000													22	58					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27343200	27343200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:27343200G>A	ENST00000429845.2	-	14	1517	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	NEK10_ENST00000341435.5_Silent_p.F385F			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	385							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CTTGAAGTGAGAAAGTATTTT	0.353000													3	11					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47860722	47860722	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47860722G>A	ENST00000289672.2	-	46	6967	c.6917C>T	c.(6916-6918)tCc>tTc	p.S2306F		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2306					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TTCATCTTGGGAAAATCTCCC	0.413000													17	45					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158724951	158724951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158724951G>A	ENST00000368144.2	+	1	442	c.346G>A	c.(346-348)Gag>Aag	p.E116K		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					CCTAATCAGTGAGCAGAAGAG	0.498000													51	121					0	0	1	0	0
MIIP	60672	broad.mit.edu	37	1	12090106	12090106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12090106C>T	ENST00000235332.4	+	8	1036	c.867C>T	c.(865-867)atC>atT	p.I289I	MIIP_ENST00000436478.2_Intron|MIIP_ENST00000466860.1_3'UTR	NM_021933.3	NP_068752.2	Q5JXC2	MIIP_HUMAN	migration and invasion inhibitory protein	289										autonomic_ganglia(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						CGCTGTCGATCCTGGAGCCCC	0.682000													18	52					0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55564480	55564480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55564480C>T	ENST00000288135.5	+	3	465	c.368C>T	c.(367-369)tCc>tTc	p.S123F		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	123	Ig-like C2-type 2.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.S123F(1)		NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTTGACCGCTCCTTGTATGGG	0.473000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				10	19					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043645	71043645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71043645C>T	ENST00000272367.2	-	4	944	c.868G>A	c.(868-870)Gaa>Aaa	p.E290K	CLEC4F_ENST00000426626.1_Missense_Mutation_p.E290K	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	290					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TGCAAATTTTCCTTTAGTCCC	0.418000													55	157					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20915649	20915649	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20915649C>T	ENST00000375071.3	+	1	209	c.27C>T	c.(25-27)acC>acT	p.T9T	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	9					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	CTGCCTGCACCCTGAAGCCTG	0.657000													13	74					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156916190	156916190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156916190G>A	ENST00000257527.4	-	20	2323	c.2245C>T	c.(2245-2247)Ccc>Tcc	p.P749S	ADAM19_ENST00000430702.2_Missense_Mutation_p.P482S|ADAM19_ENST00000517905.1_Missense_Mutation_p.P749S|ADAM19_ENST00000394020.1_Missense_Mutation_p.P751S	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	749					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACCCTGAAGGGACAACTAGAA	0.547000													8	23					0	0	1	0	0
PDLIM2	64236	broad.mit.edu	37	8	22442865	22442865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22442865C>T	ENST00000265810.4	+	5	608	c.493C>T	c.(493-495)Ccc>Tcc	p.P165S	PDLIM2_ENST00000397760.4_Missense_Mutation_p.P165S|PDLIM2_ENST00000448520.1_3'UTR|PDLIM2_ENST00000397761.2_Missense_Mutation_p.P165S|PDLIM2_ENST00000339162.7_Missense_Mutation_p.P165S|PDLIM2_ENST00000409141.1_Missense_Mutation_p.P165S|PDLIM2_ENST00000308354.7_Missense_Mutation_p.P415S|PDLIM2_ENST00000409417.1_Missense_Mutation_p.P165S	NM_176871.3	NP_789847.1	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 (mystique)	165						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		CCCGGGCCTCCCCGCTGCTGA	0.677000													9	16					0	0	1	0	0
CLDN8	9073	broad.mit.edu	37	21	31588018	31588018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31588018C>T	ENST00000399899.1	-	1	373	c.226G>A	c.(226-228)Gac>Aac	p.D76N	CLDN8_ENST00000286809.1_Missense_Mutation_p.D76N	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	76					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						GCCTGTAGGTCCGGAGAAAGA	0.512000													33	72					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76732370	76732370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76732370C>T	ENST00000287239.4	+	7	1523	c.1034C>T	c.(1033-1035)cCg>cTg	p.P345L	KAT6B_ENST00000372714.1_Missense_Mutation_p.P345L|KAT6B_ENST00000372725.1_Missense_Mutation_p.P345L|KAT6B_ENST00000372711.1_Missense_Mutation_p.P345L|KAT6B_ENST00000372724.1_Missense_Mutation_p.P345L	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	345					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										ATTGGACGACCGAAAAATAAA	0.338000													53	158					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327598	85327598	+	Silent	SNP	C	C	T	rs148220929		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85327598C>T	ENST00000299927.3	+	1	1714	c.1692C>T	c.(1690-1692)ccC>ccT	p.P564P	ZNF592_ENST00000560079.2_Silent_p.P564P			Q92610	ZN592_HUMAN	zinc finger protein 592	564					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCTCCAACCCCGTGCCCCTCT	0.592000													53	184					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230902178	230902178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230902178C>T	ENST00000295190.4	-	5	1909	c.1451G>A	c.(1450-1452)gGa>gAa	p.G484E		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	484						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		AAAGAGTATTCCTATCATGTA	0.333000													18	49					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16205242	16205242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16205242C>T	ENST00000399408.2	+	23	3087	c.2912C>T	c.(2911-2913)tCc>tTc	p.S971F	ABCC1_ENST00000349029.5_Missense_Mutation_p.S846F|ABCC1_ENST00000345148.5_Missense_Mutation_p.S961F|ABCC1_ENST00000346370.5_Missense_Mutation_p.S905F|ABCC1_ENST00000399410.3_Missense_Mutation_p.S961F|ABCC1_ENST00000351154.5_Missense_Mutation_p.S902F			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	961					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTCAAGCTTTCCGTGTACTGG	0.557000													55	142					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53220037	53220037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53220037C>T	ENST00000394729.2	+	11	1408	c.1080C>T	c.(1078-1080)ttC>ttT	p.F360F	PRKCD_ENST00000330452.3_Silent_p.F360F	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	360	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		AAGGCAGCTTCGGGAAGGTGA	0.607000													12	39					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898763	36898763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36898763C>T	ENST00000301807.6	-	12	2565	c.668G>A	c.(667-669)tGg>tAg	p.W223*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.W773*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.W223*	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	773					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CTGCGTGCTCCAGTCATCCTG	0.542000													76	297					0	0	1	0	0
LINC01098	285501	broad.mit.edu	37	4	178897018	178897018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:178897018G>A	ENST00000507870.1	+	5	683	c.221G>A	c.(220-222)gGg>gAg	p.G74E																	lung(8)|prostate(1)	9						ACGGGAAAGGGGTTGAGCAAG	0.403000													41	102					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42719313	42719313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:42719313C>T	ENST00000230882.4	+	10	1894	c.1704C>T	c.(1702-1704)acC>acT	p.T568T	GHR_ENST00000357703.3_Silent_p.T546T|GHR_ENST00000537449.1_Silent_p.T381T	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	568					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTTACATCACCACAGAAAGCC	0.488000													9	32					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821046	43821046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43821046C>T	ENST00000417669.1	+	2	499	c.55C>T	c.(55-57)Ctc>Ttc	p.L19F	MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000443721.1_Missense_Mutation_p.L19F|MPPED1_ENST00000542779.1_Missense_Mutation_p.L19F|MPPED1_ENST00000538182.1_Missense_Mutation_p.L52F			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	19							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				CCTGGCCCTCCTCCCCTGCGG	0.711000													5	27					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129853969	129853969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:129853969C>T	ENST00000373425.3	-	4	1879	c.1262G>A	c.(1261-1263)aGa>aAa	p.R421K	RALGPS1_ENST00000424082.2_Intron|ANGPTL2_ENST00000373417.1_Missense_Mutation_p.R119K|RALGPS1_ENST00000373436.1_Intron|RALGPS1_ENST00000259351.5_Intron|RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000373434.1_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	421	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						ATCATGATCTCTGTCCAGGGT	0.552000													75	239					0	0	1	0	0
SRP72	6731	broad.mit.edu	37	4	57350913	57350913	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:57350913C>T	ENST00000342756.5	+	10	1690	c.969C>T	c.(967-969)tgC>tgT	p.C323C	SRP72_ENST00000510663.1_Silent_p.C262C	NM_006947.3	NP_008878.3	O76094	SRP72_HUMAN	signal recognition particle 72kDa	323					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					CTGAACAATGCCGCAAAATAT	0.413000													33	144					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57372430	57372430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57372430G>A	ENST00000361249.3	+	8	1283	c.1187G>A	c.(1186-1188)gGa>gAa	p.G396E		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	396	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGTTTATCAGGAGACCATTGT	0.423000													53	127					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7770734	7770734	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:7770734G>A	ENST00000420658.1	-	17	2527	c.2253_splice	c.e17-1	p.S752_splice	AFAP1_ENST00000358461.2_Splice_Site_p.S668_splice|AFAP1_ENST00000360265.4_Splice_Site_p.S668_splice|AFAP1_ENST00000513842.1_5'UTR|AFAP1_ENST00000382543.3_Splice_Site_p.S752_splice	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	668						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						GAACACTGGAGACTTAACGGA	0.547000													36	121					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155156512	155156512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155156512C>T	ENST00000357232.3	-	25	7926	c.7927G>A	c.(7927-7929)Gaa>Aaa	p.E2643K		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2643					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GTTTCTCCTTCCACAGAACAG	0.468000													21	88					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97466366	97466366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97466366C>T	ENST00000389672.5	+	17	3266	c.3228C>T	c.(3226-3228)ttC>ttT	p.F1076F		NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	981						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AGAATAACTTCGTGGCAGCAG	0.423000													12	16					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112144721	112144721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112144721C>T	ENST00000412145.1	-	19	4549	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K	PTPN3_ENST00000446349.1_Missense_Mutation_p.E621K|PTPN3_ENST00000394827.3_Missense_Mutation_p.E265K|PTPN3_ENST00000262539.3_Missense_Mutation_p.E643K|PTPN3_ENST00000374541.2_Missense_Mutation_p.E797K	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	797	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GTGTGTTCTTCCCCGGTCTGT	0.577000													30	23					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119729101	119729101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:119729101G>A	ENST00000541757.1	+	5	597	c.217G>A	c.(217-219)Ggc>Agc	p.G73S	MARCO_ENST00000327097.4_Missense_Mutation_p.G151S			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	151					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGGTGAACAAGGCGCCCCAGG	0.582000													39	88					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38793802	38793802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38793802G>A	ENST00000449082.2	-	11	1662	c.1663C>T	c.(1663-1665)Cct>Tct	p.P555S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	555					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTGGGTTGAGGAAGAGGGCTT	0.602000													30	76					0	0	1	0	0
TMEM30A	55754	broad.mit.edu	37	6	75994289	75994289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:75994289G>A	ENST00000230461.6	-	1	395	c.66C>T	c.(64-66)acC>acT	p.T22T	TMEM30A_ENST00000475111.2_Silent_p.T22T	NM_018247.3	NP_060717.1	Q9NV96	CC50A_HUMAN	transmembrane protein 30A	22						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(8)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GAGTCTTCGCGGTGCCCCCCG	0.617000													21	139					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515442	140515442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140515442C>T	ENST00000231134.5	+	1	643	c.426C>T	c.(424-426)atC>atT	p.I142I		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		142	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTAAAAATCCCAGAGAGCA	0.438000													20	87					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40312406	40312406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:40312406C>T	ENST00000264661.3	-	16	3038	c.2706G>A	c.(2704-2706)cgG>cgA	p.R902R	KCNH4_ENST00000607371.1_Silent_p.R902R	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	902					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCATGATGTGCCGCAGCTCCC	0.592000													16	34					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37388776	37388776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37388776C>T	ENST00000361924.2	+	21	6939	c.6565C>T	c.(6565-6567)Cgt>Tgt	p.R2189C	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.R2204C	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	2189	GRIP.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TATGATGGGTCGTGAGACTAA	0.368000													11	96					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21348460	21348460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21348460C>T	ENST00000215739.8	+	14	1876	c.1517C>T	c.(1516-1518)cCg>cTg	p.P506L	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Missense_Mutation_p.P487L	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	506	BTB 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GGGGCCCGGCCGCCCCTGCTG	0.682000													6	14					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96522620	96522620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96522620C>T	ENST00000371321.3	+	1	240	c.158C>T	c.(157-159)tCc>tTc	p.S53F	CYP2C19_ENST00000464755.1_Intron	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	53					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GTCAGCAAATCCTTAACCAAT	0.403000													30	66					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149903251	149903251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149903251G>A	ENST00000439741.2	-	13	1441	c.1191C>T	c.(1189-1191)gcC>gcT	p.A397A	MTMR11_ENST00000406732.3_Intron|MTMR11_ENST00000369140.3_Silent_p.A325A|MTMR11_ENST00000361405.6_Intron|MTMR11_ENST00000492824.1_Intron	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	397	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACAGTGTTCGGGCTTCGGGGG	0.567000													12	79					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37680644	37680644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37680644G>A	ENST00000532828.2	-	4	462	c.211C>T	c.(211-213)Cct>Tct	p.P71S	ZNF585B_ENST00000531805.1_Missense_Mutation_p.P16S|CTC-454I21.3_ENST00000585860.2_Missense_Mutation_p.P71S|ZNF585B_ENST00000527838.1_Missense_Mutation_p.P71S|ZNF585B_ENST00000586320.1_Missense_Mutation_p.P56S	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTGGTTTAGGAACTTGATAC	0.478000													28	63					0	0	1	0	0
S1PR3	1903	broad.mit.edu	37	9	91616823	91616823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91616823G>A	ENST00000375846.3	+	1	5403	c.708G>A	c.(706-708)gaG>gaA	p.E236E	S1PR3_ENST00000358157.2_Silent_p.E236E			Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	236					anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(1)	34						ACAACTCGGAGCGGTCCATGG	0.577000													14	51					0	0	1	0	0
SLC2A12	154091	broad.mit.edu	37	6	134349893	134349893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:134349893G>A	ENST00000275230.5	-	2	1225	c.1070C>T	c.(1069-1071)tCg>tTg	p.S357L		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	357						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		GGTCACCAACGAAGCTGCCAT	0.493000													23	50					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344463	56344463	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56344463C>T	ENST00000526812.2	-	1	800	c.735G>A	c.(733-735)ctG>ctA	p.L245L		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						TGACTATTGTCAGGTGGGAAG	0.428000													13	137					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43614358	43614358	+	Silent	SNP	G	G	A	rs142184960		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43614358G>A	ENST00000360835.3	-	15	1920	c.1794C>T	c.(1792-1794)gtC>gtT	p.V598V		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	598					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				CAGTGCCTGAGACCTGGACAT	0.647000													75	102					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42227377	42227377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42227377G>A	ENST00000541110.1	-	9	2597	c.2029C>T	c.(2029-2031)Cgg>Tgg	p.R677W	TRERF1_ENST00000340840.2_Missense_Mutation_p.R574W|TRERF1_ENST00000354325.2_Missense_Mutation_p.R574W|TRERF1_ENST00000372917.4_Missense_Mutation_p.R574W|TRERF1_ENST00000372922.4_Missense_Mutation_p.R657W			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	657	Interacts with CREBBP.|Pro-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGTTCCGGCCGGTGCCGGAAC	0.637000													12	87					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43492321	43492321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43492321G>A	ENST00000282041.5	-	22	3951	c.3917C>T	c.(3916-3918)cCc>cTc	p.P1306L	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1306					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TGGCAGGAGGGGGTGATCAGA	0.557000													10	75					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81634807	81634807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:81634807G>A	ENST00000356860.3	-	18	1860	c.1522C>T	c.(1522-1524)Ccc>Tcc	p.P508S	CACNA2D1_ENST00000356253.5_Missense_Mutation_p.P508S|CACNA2D1_ENST00000464354.1_5'UTR	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	508	Cache.					voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TACCCATTGGGGCACAGCTGG	0.303000													3	10					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156816441	156816441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156816441C>T	ENST00000368195.3	-	8	2076	c.1680G>A	c.(1678-1680)gtG>gtA	p.V560V	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	560	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGGCTAGGGTCACCCCTGGCT	0.612000													8	62					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38516844	38516844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38516844C>T	ENST00000399017.2	+	21	4539	c.1792C>T	c.(1792-1794)Cac>Tac	p.H598Y	TTC3_ENST00000540756.1_Missense_Mutation_p.H288Y|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000355666.1_Missense_Mutation_p.H598Y|TTC3_ENST00000354749.2_Missense_Mutation_p.H598Y	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	598					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				AGCTCTCAATCACTTTGAGAA	0.348000													11	143					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371732	240371732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240371732C>T	ENST00000319653.9	+	5	3850	c.3620C>T	c.(3619-3621)cCc>cTc	p.P1207L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1207	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCTGGGATTCCCCCACCTCCT	0.657000													18	26					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45309885	45309885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45309885G>A	ENST00000313237.5	-	5	798	c.648C>T	c.(646-648)ccC>ccT	p.P216P	PHF21B_ENST00000403565.1_Intron|PHF21B_ENST00000404079.2_Intron|PHF21B_ENST00000447824.3_Intron|PHF21B_ENST00000396103.3_Intron	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	216							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		gtgatggggagggaggggtga	0.642000													20	40					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	818660	818660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:818660G>A	ENST00000566549.1	+	17	2213	c.1796G>A	c.(1795-1797)gGg>gAg	p.G599E	MSLN_ENST00000382862.3_Missense_Mutation_p.G607E|MSLN_ENST00000545450.2_Missense_Mutation_p.G599E|MSLN_ENST00000563941.1_Missense_Mutation_p.G599E			Q13421	MSLN_HUMAN	mesothelin	607					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				GCCCTCTCGGGGACGCCCTGC	0.711000													10	50					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73044544	73044544	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73044544G>A	ENST00000335350.6	+	3	788	c.372G>A	c.(370-372)gaG>gaA	p.E124E	UNC5B_ENST00000373192.4_Silent_p.E124E	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	124	Ig-like.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						TTGGGCTGGAGGATTACTGGT	0.682000													37	72					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125288811	125288811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125288811G>A	ENST00000304880.2	-	1	761	c.762C>T	c.(760-762)ttC>ttT	p.F254F		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	254					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F254F(1)		breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						GGTAGGCACTGAAGAGGGTCC	0.542000													25	40					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124380660	124380660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124380660G>A	ENST00000338354.3	+	41	5091	c.4985G>A	c.(4984-4986)gGa>gAa	p.G1662E	DMBT1_ENST00000344338.3_Missense_Mutation_p.G1652E|DMBT1_ENST00000368955.3_Missense_Mutation_p.G1652E|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Missense_Mutation_p.G1034E|DMBT1_ENST00000368956.2_Missense_Mutation_p.G1034E|DMBT1_ENST00000368909.3_Missense_Mutation_p.G1662E			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1662	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGCTCCTGGGGAACCGTGTGT	0.592000													117	324					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58954710	58954710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:58954710C>T	ENST00000423743.3	+	24	3536	c.3278C>T	c.(3277-3279)tCc>tTc	p.S1093F	KIAA0586_ENST00000556134.1_Missense_Mutation_p.S1122F|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000261244.5_Missense_Mutation_p.S1061F|KIAA0586_ENST00000354386.6_Missense_Mutation_p.S1190F	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	1061										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCAGATATTTCCATTGATAAA	0.473000													11	19					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071765	9071765	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9071765G>A	ENST00000397910.4	-	3	15884	c.15681C>T	c.(15679-15681)gtC>gtT	p.V5227V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5229	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGAAGAGTTGACCCCTGTAC	0.498000													19	128					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409091	105409091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105409091C>T	ENST00000333244.5	-	7	12816	c.12697G>A	c.(12697-12699)Ggc>Agc	p.G4233S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4233						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACCTGGGGGCCCTTGAGGGCC	0.647000													84	235					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038703	75038703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75038703C>T	ENST00000326665.5	-	14	2909	c.2691G>A	c.(2689-2691)caG>caA	p.Q897Q	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	897	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCTCTAAACCCTGTTCCCCTT	0.512000													85	265					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513626	78513626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:78513626C>T	ENST00000397909.2	+	15	3823	c.3650C>T	c.(3649-3651)tCc>tTc	p.S1217F	NAV3_ENST00000228327.6_Missense_Mutation_p.S1217F|NAV3_ENST00000536525.2_Missense_Mutation_p.S1217F|NAV3_ENST00000266692.7_Missense_Mutation_p.S1217F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1217	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTGTCAGGTTCCCCCAAATCC	0.522000										HNSCC(70;0.22)			25	82					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117292939	117292939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117292939C>T	ENST00000003084.6	+	24	4049	c.3917C>T	c.(3916-3918)cCc>cTc	p.P1306L	CFTR_ENST00000454343.1_Missense_Mutation_p.P1245L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1306	ABC transporter 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AACTTGGATCCCTATGAACAG	0.299000									Cystic Fibrosis				8	95					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6091073	6091073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6091073G>A	ENST00000217289.4	-	5	1406	c.618C>T	c.(616-618)ttC>ttT	p.F206F	FERMT1_ENST00000536936.1_Intron	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	206	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						GGCTGTCACTGAACCAAGTCA	0.522000													27	105					0	0	1	0	0
ARNTL2	56938	broad.mit.edu	37	12	27553473	27553473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:27553473G>A	ENST00000544915.1	+	9	1043	c.824G>A	c.(823-825)aGa>aAa	p.R275K	ARNTL2_ENST00000311001.5_Missense_Mutation_p.R295K|ARNTL2_ENST00000261178.5_Missense_Mutation_p.R261K|ARNTL2_ENST00000266503.5_Missense_Mutation_p.R309K|RP11-165P7.1_ENST00000500498.2_RNA|ARNTL2_ENST00000542388.1_Missense_Mutation_p.R224K|ARNTL2_ENST00000395901.2_Missense_Mutation_p.R272K|ARNTL2_ENST00000546179.1_Missense_Mutation_p.R272K	NM_020183.4	NP_064568.3	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear translocator-like 2	309					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	21	Colorectal(261;0.0847)|Lung SC(9;0.184)					TTAGAGCACAGAAAATTCTAT	0.294000													26	58					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476429	57476429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57476429G>A	ENST00000371236.2	-	14	1870	c.1607C>T	c.(1606-1608)cCa>cTa	p.P536L	DAB1_ENST00000420954.2_Missense_Mutation_p.P534L|DAB1_ENST00000439789.2_Missense_Mutation_p.P450L|DAB1_ENST00000371234.4_Missense_Mutation_p.P536L|DAB1_ENST00000371231.1_Missense_Mutation_p.P569L|DAB1_ENST00000414851.2_Missense_Mutation_p.P518L|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	569					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CTCACCAAATGGATCACTGTT	0.438000													32	84					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111409813	111409813	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111409813G>A	ENST00000265162.5	+	2	1103	c.761G>A	c.(760-762)gGa>gAa	p.G254E		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	254					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AAAGAATACGGAGCACTTTCA	0.383000													62	36					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130833139	130833139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130833139G>A	ENST00000357462.5	-	15	1999	c.1906C>T	c.(1906-1908)Ctt>Ttt	p.L636F	POTEF_ENST00000360967.5_3'UTR|POTEF_ENST00000409914.2_Missense_Mutation_p.L636F|POTEF_ENST00000361163.4_3'UTR			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	636						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TTACAACTAAGAGAAAGCTAA	0.323000													7	30					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884112	39884112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39884112C>T	ENST00000341184.6	+	2	975	c.760C>T	c.(760-762)Cgg>Tgg	p.R254W		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	254					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GCTCAAGTTCCGGGAGATGCT	0.642000													27	72					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36641484	36641484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36641484G>A	ENST00000373448.2	-	3	973	c.735C>T	c.(733-735)ttC>ttT	p.F245F	TTI1_ENST00000373447.3_Silent_p.F245F|TTI1_ENST00000449821.1_Silent_p.F245F|TTI1_ENST00000487362.1_Intron	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	245							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						CAGCCATAATGAAGCTCACTG	0.433000													72	168					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964677	70964677	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70964677G>A	ENST00000357250.6	-	24	1812	c.1654C>T	c.(1654-1656)Cct>Tct	p.P552S	COL9A1_ENST00000370499.4_Missense_Mutation_p.P309S|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000320755.7_Missense_Mutation_p.P309S	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	552	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						TTTGTTCCAGGCATTCCAGGG	0.468000													11	27					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71604216	71604216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71604216G>A	ENST00000355962.4	-	9	1130	c.997C>T	c.(997-999)Cgc>Tgc	p.R333C	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	333					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CCCGGGGTGCGACATAGGATG	0.547000													22	52					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581261	234581261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234581261C>T	ENST00000354728.4	+	1	763	c.681C>T	c.(679-681)gcC>gcT	p.A227A	UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		TCAAAAATGCCCTAGAAATAG	0.423000													89	440					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152605214	152605214	+	Missense_Mutation	SNP	C	C	T	rs147615757		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152605214C>T	ENST00000367255.5	-	96	18707	c.18106G>A	c.(18106-18108)Gac>Aac	p.D6036N	SYNE1_ENST00000448038.1_Missense_Mutation_p.D5965N|SYNE1_ENST00000423061.1_Missense_Mutation_p.D5965N|SYNE1_ENST00000265368.4_Missense_Mutation_p.D6036N|SYNE1_ENST00000341594.5_Missense_Mutation_p.D5648N|SYNE1_ENST00000356820.4_Missense_Mutation_p.D560N	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6036					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCGCAGGGTCGGCCTCACAA	0.562000										HNSCC(10;0.0054)			20	30					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140438247	140438247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140438247G>A	ENST00000406427.1	-	5	630	c.294C>T	c.(292-294)acC>acT	p.T98T	PNPLA7_ENST00000277531.4_Silent_p.T73T	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	73					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TCTCCACAAGGGTGTTGGGGA	0.602000													25	44					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766568	27766568	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27766568T>A	ENST00000451261.2	+	5	1955	c.1556T>A	c.(1555-1557)cTt>cAt	p.L519H		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						ATAAACTGTCTTGAACCCCAC	0.507000													11	3					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39915756	39915756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39915756C>T	ENST00000425673.1	+	17	4221	c.3896C>T	c.(3895-3897)cCc>cTc	p.P1299L	PLEKHG2_ENST00000458508.2_Intron|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.P1328L|PLEKHG2_ENST00000409797.2_Intron			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	1328					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCACCACCTCCCCCAGCCAGG	0.741000													4	14					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50599869	50599869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50599869G>A	ENST00000540615.1	+	26	3695	c.3475G>A	c.(3475-3477)Gcc>Acc	p.A1159T	MOV10L1_ENST00000262794.5_Silent_p.E1209E|MOV10L1_ENST00000545383.1_Silent_p.E1209E|MOV10L1_ENST00000395852.1_Silent_p.E336E|MOV10L1_ENST00000395858.3_Silent_p.E1163E	NM_001164105.1	NP_001157577.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	0					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGCATCAGGAGCCCAGCTGAT	0.627000													3	12					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9118220	9118220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9118220G>A	ENST00000377424.4	-	2	302	c.123C>T	c.(121-123)tcC>tcT	p.S41S	SLC2A5_ENST00000377414.3_Silent_p.S41S|SLC2A5_ENST00000535586.1_Intron	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	41					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGTGCTGGGGAGTTGACAG	0.597000													21	31					0	0	1	0	0
TRAF3	7187	broad.mit.edu	37	14	103371731	103371731	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103371731C>T	ENST00000560371.1	+	11	1534	c.1317C>T	c.(1315-1317)tcC>tcT	p.S439S	TRAF3_ENST00000351691.5_Silent_p.S414S|TRAF3_ENST00000539721.1_Silent_p.S356S|TRAF3_ENST00000392745.2_Silent_p.S439S|TRAF3_ENST00000347662.4_Silent_p.S414S	NM_003300.3|NM_145725.2	NP_003291.2|NP_663777.1	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3	439	MATH.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|liver(2)|lung(7)|ovary(1)|prostate(2)	30		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		AGACCCTGTCCCTTTACAGCC	0.577000													35	58					0	0	1	0	0
HEMGN	55363	broad.mit.edu	37	9	100693400	100693400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:100693400C>T	ENST00000259456.3	-	4	420	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	93					cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				ATTTCCTTTTCTATCTGTGGC	0.443000													24	94					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178554971	178554971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178554971G>A	ENST00000251582.7	-	17	2707	c.2606C>T	c.(2605-2607)cCc>cTc	p.P869L		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	869	TSP type-1 2.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TCCGCCACAGGGCTTGGAGCA	0.612000													15	141					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985516	108985516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108985516C>T	ENST00000392806.3	-	2	812	c.644G>A	c.(643-645)gGg>gAg	p.G215E		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	215						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						TTCCTGGTCCCCCTCCTGGCT	0.687000													25	63					0	0	1	0	0
SOX9	6662	broad.mit.edu	37	17	70120479	70120479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:70120479G>A	ENST00000245479.2	+	3	1853	c.1481G>A	c.(1480-1482)aGc>aAc	p.S494N		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	494					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CAGACCCACAGCCCCCAGCAC	0.607000													10	95					0	0	1	0	0
CRIP1	1396	broad.mit.edu	37	14	105954825	105954825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105954825G>A	ENST00000330233.7	+	4	1154	c.211G>A	c.(211-213)Gcc>Acc	p.A71T	CRIP1_ENST00000551180.1_Missense_Mutation_p.S39N|CRIP1_ENST00000392531.3_Missense_Mutation_p.A71T|CRIP1_ENST00000409393.2_Missense_Mutation_p.A71T			P50238	CRIP1_HUMAN	cysteine-rich protein 1 (intestinal)	71					cell proliferation	cytoplasm	zinc ion binding						Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.235)		GCGGGGCGGAGCCGAGAGCCA	0.642000													21	71					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58209161	58209161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58209161G>A	ENST00000377918.3	+	1	2507	c.2481G>A	c.(2479-2481)caG>caA	p.Q827Q		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	827					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CTGTCCCTCAGGGGCACGCGG	0.602000													13	30					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37769835	37769835	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37769835G>A	ENST00000402918.1	-	3	2525	c.1740C>T	c.(1738-1740)tcC>tcT	p.S580S	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Silent_p.S580S	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	580						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					CTGCAGGGAGGGACTGGCACT	0.657000													11	24					0	0	1	0	0
TMEM198	130612	broad.mit.edu	37	2	220412343	220412343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220412343G>A	ENST00000344458.2	+	4	867	c.282G>A	c.(280-282)gcG>gcA	p.A94A	RP11-256I23.1_ENST00000596829.1_RNA|TMEM198_ENST00000373883.3_Silent_p.A94A			Q66K66	TM198_HUMAN	transmembrane protein 198	94	Leu-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GTGCTGGGGCGAGCGCGGGCA	0.657000													93	165					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7100082	7100082	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7100082G>A	ENST00000399510.2	-	11	2058	c.1206C>T	c.(1204-1206)atC>atT	p.I402I	DLG4_ENST00000302955.6_Silent_p.I356I|DLG4_ENST00000399506.2_Silent_p.I359I	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	359					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						TCACCGACAGGATCTGGTCCC	0.667000													5	4					0	0	1	0	0
GPR113	165082	broad.mit.edu	37	2	26537451	26537451	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26537451C>T	ENST00000333478.6	-	4	948	c.366G>A	c.(364-366)tgG>tgA	p.W122*	GPR113_ENST00000421160.2_Nonsense_Mutation_p.W252*|GPR113_ENST00000541401.1_Intron|GPR113_ENST00000311519.1_Nonsense_Mutation_p.W321*|GPR113_ENST00000459892.1_Intron	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	321					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATACAGGTTCCACTTGAAGC	0.602000													14	38					0	0	1	0	0
GABRD	2563	broad.mit.edu	37	1	1956458	1956458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1956458C>T	ENST00000378585.4	+	2	229	c.146C>T	c.(145-147)gCc>gTc	p.A49V		NM_000815.4	NP_000806.2	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	49						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GGGCTGATAGCCGGCTACGCC	0.677000													12	40					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469108	10469108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10469108C>T	ENST00000382483.3	-	4	2723	c.2500G>A	c.(2500-2502)Gcc>Acc	p.A834T		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	834					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GCCTCTTGGGCCGGCTGCGTC	0.721000													6	9					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359610	66359610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66359610G>A	ENST00000333861.3	-	1	944	c.877C>T	c.(877-879)Ccc>Tcc	p.P293S		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	293										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CTGCTGGTGGGGGCCACAGGA	0.602000													35	71					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56270365	56270365	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:56270365C>T	ENST00000327381.5	+	2	1034	c.934C>T	c.(934-936)Ctg>Ttg	p.L312L		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	312						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			AGCCACCTTTCTGGAAAGTGC	0.478000													18	47					0	0	1	0	0
GPN3	51184	broad.mit.edu	37	12	110895370	110895370	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110895370A>G	ENST00000543199.1	-	4	596	c.512T>C	c.(511-513)tTc>tCc	p.F171S	GPN3_ENST00000228827.3_Missense_Mutation_p.F132S|GPN3_ENST00000537466.2_Missense_Mutation_p.F142S	NM_001164372.1	NP_001157844.1	Q9UHW5	GPN3_HUMAN	GPN-loop GTPase 3	132						protein complex	GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|urinary_tract(1)	8						ACAGACTCGGAACTCCCACTG	0.393000													20	43					0	0	1	0	0
USP49	25862	broad.mit.edu	37	6	41774231	41774231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41774231C>T	ENST00000394253.3	-	3	820	c.491G>A	c.(490-492)cGg>cAg	p.R164Q	USP49_ENST00000373010.1_Missense_Mutation_p.R164Q|USP49_ENST00000373006.1_Missense_Mutation_p.R164Q|USP49_ENST00000373009.3_Missense_Mutation_p.R164Q|USP49_ENST00000297229.2_Missense_Mutation_p.R164Q			Q70CQ1	UBP49_HUMAN	ubiquitin specific peptidase 49	164					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(2)|skin(2)	23	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGCCTGGCCCCGGGAGCTCTT	0.721000													6	31					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587768	55587768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55587768C>T	ENST00000333976.4	+	1	683	c.663C>T	c.(661-663)ttC>ttT	p.F221F		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CTTATGCGTTCATTGTTGTAA	0.478000													25	87					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81647141	81647141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81647141C>T	ENST00000548058.1	+	14	2685	c.1775C>T	c.(1774-1776)cCc>cTc	p.P592L	ACSS3_ENST00000548324.1_Missense_Mutation_p.P274L|ACSS3_ENST00000261206.3_Missense_Mutation_p.P591L			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	592						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						AAGGAAGATCCCTTAAAAGGT	0.398000													53	216					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151729515	151729515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:151729515G>A	ENST00000535741.1	-	32	5814	c.5341C>T	c.(5341-5343)Cca>Tca	p.P1781S	LRBA_ENST00000510413.1_Missense_Mutation_p.P1781S|LRBA_ENST00000507224.1_Missense_Mutation_p.P1781S|LRBA_ENST00000357115.3_Missense_Mutation_p.P1781S			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1781						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TCAACTGTTGGAACTGAGGGC	0.294000													33	69					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377838	55377838	+	Missense_Mutation	SNP	G	G	A	rs138770759	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55377838G>A	ENST00000326321.3	+	8	1152	c.1119G>A	c.(1117-1119)atG>atA	p.M373I	KIR3DL2_ENST00000270442.5_Missense_Mutation_p.M356I|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.M373I	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	373					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		CTGCTGTAATGGACCAAGAGC	0.552000													42	120					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48729211	48729211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48729211G>A	ENST00000316623.5	-	53	6898	c.6443C>T	c.(6442-6444)tCc>tTc	p.S2148F		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2148	EGF-like 36; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCAGCGATAGGAACCATCTGT	0.358000													25	71					0	0	1	0	0
OLR1	4973	broad.mit.edu	37	12	10312586	10312586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10312586G>A	ENST00000309539.3	-	6	775	c.715C>T	c.(715-717)Cct>Tct	p.P239S	OLR1_ENST00000432556.2_3'UTR|OLR1_ENST00000545927.1_3'UTR|OLR1_ENST00000544577.1_Intron|OLR1_ENST00000543993.1_3'UTR	NM_002543.3	NP_002534.1	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like) receptor 1	239	C-type lectin.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						GTACCTGAAGGGTATGTCTGG	0.428000													35	135					0	0	1	0	0
CCDC94	55702	broad.mit.edu	37	19	4268649	4268649	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4268649C>T	ENST00000262962.7	+	8	996	c.928C>T	c.(928-930)Ctg>Ttg	p.L310L		NM_018074.4	NP_060544.2	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	310										NS(1)|endometrium(1)|lung(2)|ovary(1)|stomach(2)	7				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		CCTGAGCCAACTGGGTGCATA	0.622000													7	28					0	0	1	0	0
TBC1D5	9779	broad.mit.edu	37	3	17418070	17418070	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:17418070G>A	ENST00000253692.7	-	10	2312	c.648C>T	c.(646-648)gtC>gtT	p.V216V	TBC1D5_ENST00000446818.2_Silent_p.V216V|TBC1D5_ENST00000429924.2_Silent_p.V168V|TBC1D5_ENST00000429383.4_Silent_p.V216V|TBC1D5_ENST00000414318.2_Intron	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	216	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						CACAGTGAAGGACAAAGACTA	0.418000													19	67					0	0	1	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32975941	32975941	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32975941C>T	ENST00000229829.5	-	2	255	c.180G>A	c.(178-180)gtG>gtA	p.V60V	HLA-DOA_ENST00000450833.2_Silent_p.V30V	NM_002119.3	NP_002110.1	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO alpha	60	Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	9						TCTTCAGGTCCACAGAGAACA	0.602000													19	48					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	76055823	76055823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76055823G>A	ENST00000377636.3	-	1	427	c.81C>T	c.(79-81)ggC>ggT	p.G27G	TBC1D4_ENST00000431480.2_Silent_p.G27G|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000377625.2_Silent_p.G27G	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	27						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GCTTCCCGGGGCCGGGCTGAG	0.687000													6	19					0	0	1	0	0
CEP89	84902	broad.mit.edu	37	19	33390817	33390817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33390817G>A	ENST00000305768.4	-	16	1909	c.1821C>T	c.(1819-1821)aaC>aaT	p.N607N		NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	607						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						GGCCAACAAGGTTTGCCAGGT	0.428000													36	100					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489348	133489348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133489348C>T	ENST00000409261.1	-	17	5778	c.5405G>A	c.(5404-5406)aGg>aAg	p.R1802K	NCKAP5_ENST00000405974.3_Missense_Mutation_p.R483K|NCKAP5_ENST00000409213.1_Missense_Mutation_p.R483K|NCKAP5_ENST00000317721.6_Missense_Mutation_p.R1802K	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1802							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTGAAGAGGCCTCATCCCTCT	0.517000													26	50					0	0	1	0	0
NEUROG1	4762	broad.mit.edu	37	5	134870797	134870797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134870797G>A	ENST00000314744.4	-	1	842	c.584C>T	c.(583-585)cCg>cTg	p.P195L		NM_006161.2	NP_006152.2	Q92886	NGN1_HUMAN	neurogenin 1	195					positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	nucleus	chromatin binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			endometrium(1)|liver(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCAGAGAGCGGGGAGGCGGC	0.716000													6	40					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101971537	101971537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101971537C>T	ENST00000348070.1	-	5	641	c.642G>A	c.(640-642)ctG>ctA	p.L214L	PCSK6_ENST00000331826.7_Silent_p.L49L|PCSK6_ENST00000344273.2_Silent_p.L214L|PCSK6_ENST00000398181.2_Silent_p.L214L|PCSK6_ENST00000358417.3_Silent_p.L214L|PCSK6_ENST00000561177.1_5'UTR	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	215	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AATTTGGGGCCAGGTCAGGGT	0.448000													14	50					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406213	55406213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55406213C>T	ENST00000314612.2	+	1	380	c.380C>T	c.(379-381)cCc>cTc	p.P127L		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						ATTTGCAAGCCCCTGCACTAC	0.423000													23	74					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974415	29974415	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29974415G>A	ENST00000376797.3	-	0	1346				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							TGCTGCTCTCGGGGACCCTGG	0.706000													18	41					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178564848	178564848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178564848C>T	ENST00000251582.7	-	12	1974	c.1873G>A	c.(1873-1875)Gag>Aag	p.E625K		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	625	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CGGCACTGCTCCTCGCGGAAG	0.701000													3	5					0	0	1	0	0
ELAC2	60528	broad.mit.edu	37	17	12903528	12903528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12903528G>A	ENST00000338034.4	-	15	1607	c.1368C>T	c.(1366-1368)ttC>ttT	p.F456F	ELAC2_ENST00000395962.2_Silent_p.F437F|ELAC2_ENST00000426905.3_Silent_p.F416F	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	456					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						CGCTCTGCTGGAAGTTGGGAA	0.577000													15	29					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22855192	22855192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22855192C>T	ENST00000283645.4	+	13	1783	c.1653C>T	c.(1651-1653)ttC>ttT	p.F551F	TUBGCP5_ENST00000559846.1_3'UTR|TUBGCP5_ENST00000453949.2_Silent_p.F551F	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	551					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TGGTGTCCTTCCTCAAACCTG	0.542000													18	61					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124439967	124439967	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124439967G>A	ENST00000284287.3	+	1	75	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GCCTTTTAATGGGGTTCTTGT	0.532000													6	53					0	0	1	0	0
OR2AG2	338755	broad.mit.edu	37	11	6790008	6790008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6790008G>A	ENST00000338569.2	-	1	278	c.181C>T	c.(181-183)Ctc>Ttc	p.L61F		NM_001004490.1	NP_001004490.1	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG, member 2	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(13)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	28		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCAAGCAGGAGGTACATGGGC	0.522000													11	161					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40790031	40790031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40790031C>T	ENST00000373198.3	-	18	2944	c.2709G>A	c.(2707-2709)atG>atA	p.M903I	PTPRT_ENST00000373187.1_Missense_Mutation_p.M881I|PTPRT_ENST00000373193.3_Missense_Mutation_p.M884I|PTPRT_ENST00000373201.1_Missense_Mutation_p.M871I|PTPRT_ENST00000373184.1_Missense_Mutation_p.M871I|PTPRT_ENST00000356100.2_Missense_Mutation_p.M890I|PTPRT_ENST00000373190.1_Missense_Mutation_p.M880I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	881	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCCTCTCTTCATCTGCGTGA	0.562000													28	73					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90129103	90129103	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90129103C>T	ENST00000268138.7	+	4	1446	c.1341C>T	c.(1339-1341)tcC>tcT	p.S447S	RP11-429B14.1_ENST00000559041.1_RNA|TICRR_ENST00000560985.1_Silent_p.S446S					TOPBP1-interacting checkpoint and replication regulator																		ACACAGCTTCCCTTTTCTCAG	0.478000													15	140					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104062929	104062929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104062929G>A	ENST00000265148.3	-	35	5530	c.5441C>T	c.(5440-5442)tCa>tTa	p.S1814L	CENPE_ENST00000380026.3_Missense_Mutation_p.S1789L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1814					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTAGCATTTGAATTTTCTAA	0.313000													4	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179441363	179441363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179441363C>T	ENST00000589042.1	-	325	69832	c.69608G>A	c.(69607-69609)gGa>gAa	p.G23203E	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G20635E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G21562E|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G14330E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G14263E|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G14138E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21562	Fibronectin type-III 68.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTGCAGTCCTGTTACTTT	0.443000													87	217					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46967040	46967040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46967040C>T	ENST00000264318.3	-	8	2063	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	361					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCGGGAACTTCCTGAGGGGGC	0.443000													34	62					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43052897	43052897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43052897C>T	ENST00000443598.2	+	8	1221	c.1132C>T	c.(1132-1134)Ccg>Tcg	p.P378S	HNF4A_ENST00000415691.1_Intron|HNF4A_ENST00000316099.3_Intron|HNF4A_ENST00000457232.1_Intron	NM_001030004.2|NM_178850.2	NP_001025175.1|NP_849181.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	377					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCTGGGAGGTCCGTGCCAAGC	0.607000													9	19					0	0	1	0	0
IFNA10	3446	broad.mit.edu	37	9	21206699	21206699	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21206699G>A	ENST00000357374.2	-	1	443	c.398C>T	c.(397-399)cCc>cTc	p.P133L		NM_002171.1	NP_002162.1	P01566	IFN10_HUMAN	interferon, alpha 10	133					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|large_intestine(3)|liver(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		ATTCATCAGGGGAGTCTCTTC	0.463000													53	153					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169801120	169801120	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169801120G>A	ENST00000263817.6	-	21	2729	c.2605C>T	c.(2605-2607)Caa>Taa	p.Q869*		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	869	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTCACCCCTTGAACTTGGGAA	0.433000													23	226					0	0	1	0	0
IL12A	3592	broad.mit.edu	37	3	159708044	159708044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159708044C>T	ENST00000305579.2	+	2	516	c.209C>T	c.(208-210)cCa>cTa	p.P70L	IL12A_ENST00000480787.1_Missense_Mutation_p.P70L|CTD-2049J23.2_ENST00000497452.1_RNA|IL12A_ENST00000466512.1_Missense_Mutation_p.P70L	NM_000882.3	NP_000873.2	P29459	IL12A_HUMAN	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	36					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	9			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGAATGTTCCCATGCCTTCAC	0.602000													17	60					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4153809	4153809	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4153809G>A	ENST00000404826.2	+	25	3865	c.3726G>A	c.(3724-3726)ctG>ctA	p.L1242L	SDK1_ENST00000389531.3_Silent_p.L1242L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1242	Fibronectin type-III 6.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCGAGGAGCTGGAGGAGTGGA	0.632000													13	32					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152496920	152496920	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152496920G>A	ENST00000427231.2	-	61	8836	c.8634C>T	c.(8632-8634)ccC>ccT	p.P2878P	NEB_ENST00000604864.1_Silent_p.P2878P|NEB_ENST00000603639.1_Silent_p.P2878P|NEB_ENST00000172853.10_Silent_p.P2878P|NEB_ENST00000397345.3_Silent_p.P2878P|NEB_ENST00000409198.1_Silent_p.P2878P	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2878					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CGCTCTGGTCGGGCAGGCATG	0.547000													70	220					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62298879	62298879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62298879G>A	ENST00000378024.4	-	5	3284	c.3010C>T	c.(3010-3012)Ccc>Tcc	p.P1004S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1004					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTAAATTTGGGCATTTTAATC	0.468000													57	152					0	0	1	0	0
FOXB2	442425	broad.mit.edu	37	9	79635164	79635164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79635164C>T	ENST00000376708.1	+	1	594	c.594C>T	c.(592-594)ccC>ccT	p.P198P		NM_001013735.1	NP_001013757.1	Q5VYV0	FOXB2_HUMAN	forkhead box B2	198					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|lung(8)|ovary(1)	10						CGTCACAGCCCCCGCAGCAAC	0.766000													10	17					0	0	1	0	0
HOXD10	3236	broad.mit.edu	37	2	176982006	176982006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:176982006C>T	ENST00000249501.4	+	1	700	c.445C>T	c.(445-447)Cct>Tct	p.P149S	HOXD10_ENST00000490088.2_Intron	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	149						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GGTTCCCGTCCCTGGATATTT	0.537000													62	167					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9382181	9382181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9382181G>A	ENST00000378501.2	+	17	1570	c.1555G>A	c.(1555-1557)Gaa>Aaa	p.E519K	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.E519K|PLCB4_ENST00000278655.4_Missense_Mutation_p.E519K|PLCB4_ENST00000378493.1_Missense_Mutation_p.E519K|PLCB4_ENST00000334005.3_Missense_Mutation_p.E519K|PLCB4_ENST00000378473.3_Missense_Mutation_p.E519K	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	519					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						ATTTGGAAATGAACTTTCTGC	0.458000													18	30					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180043925	180043925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180043925C>T	ENST00000261937.6	-	22	3149	c.3071G>A	c.(3070-3072)gGg>gAg	p.G1024E	FLT4_ENST00000393347.3_Missense_Mutation_p.G1024E|FLT4_ENST00000502649.1_Missense_Mutation_p.G1024E	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1024	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GAACTCCATCCCTCTGGCCAC	0.602000													26	70					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34064204	34064204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34064204C>T	ENST00000389232.4	+	63	8970	c.8900C>T	c.(8899-8901)aCt>aTt	p.T2967I	RYR3_ENST00000415757.3_Missense_Mutation_p.T2967I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2967					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGGAGAAGACTTCAGAAAAC	0.458000													4	23					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171086461	171086461	+	Missense_Mutation	SNP	C	C	T	rs61008738	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171086461C>T	ENST00000367755.4	+	9	1589	c.1478C>T	c.(1477-1479)tCg>tTg	p.S493L	FMO3_ENST00000538429.1_Missense_Mutation_p.S430L|FMO3_ENST00000392085.2_Missense_Mutation_p.S493L|FMO3_ENST00000542847.1_Missense_Mutation_p.S473L	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	493					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity	p.S493*(1)		endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGGACCGGTCGTTGAAACCC	0.517000													28	49					0	0	1	0	0
CASP9	842	broad.mit.edu	37	1	15844812	15844812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:15844812G>A	ENST00000546424.1	-	2	455	c.211C>T	c.(211-213)Cct>Tct	p.P71S	CASP9_ENST00000375890.4_5'UTR|CASP9_ENST00000469637.1_5'UTR|CASP9_ENST00000333868.5_Missense_Mutation_p.P71S|CASP9_ENST00000348549.5_Missense_Mutation_p.P71S			P55211	CASP9_HUMAN	caspase 9, apoptosis-related cysteine peptidase	71	CARD.				activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|stomach(1)	18		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		ATGAACAAAGGAAGAGCCTGA	0.547000													25	70					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3102863	3102863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3102863C>T	ENST00000378398.3	+	2	294	c.212C>T	c.(211-213)cCt>cTt	p.P71L	PRDM16_ENST00000378391.2_Missense_Mutation_p.P71L|PRDM16_ENST00000442529.2_Missense_Mutation_p.P71L|PRDM16_ENST00000441472.2_Missense_Mutation_p.P71L|PRDM16_ENST00000514189.1_Missense_Mutation_p.P71L|PRDM16_ENST00000511072.1_Missense_Mutation_p.P71L|PRDM16_ENST00000270722.5_Missense_Mutation_p.P71L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	71					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TACGAGGCCCCTGTCTACATT	0.657000			T	EVI1	"""MDS, AML"""								15	129					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84089651	84089651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84089651G>A	ENST00000343411.3	-	22	3416	c.2921C>T	c.(2920-2922)cCc>cTc	p.P974L		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	974					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AGGGGACAAGGGCCTCACTTG	0.502000													23	57					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231109737	231109737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231109737C>T	ENST00000392045.3	+	6	720	c.606C>T	c.(604-606)ctC>ctT	p.L202L	SP140_ENST00000417495.3_Silent_p.L202L|SP140_ENST00000486687.2_Silent_p.L202L|SP140_ENST00000420434.3_Silent_p.L202L|SP140_ENST00000350136.5_Silent_p.L182L|SP140_ENST00000343805.6_Silent_p.L202L	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	202					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGTTAGCTCTCCCAAAGGCTG	0.458000													21	66					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25281301	25281301	+	Silent	SNP	C	C	T	rs148902783		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25281301C>T	ENST00000218548.6	+	16	2661	c.2328C>T	c.(2326-2328)ttC>ttT	p.F776F	ATP12A_ENST00000381946.3_Silent_p.F770F	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	770					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ACGACAACTTCGCATCCATCG	0.552000													19	49					0	0	1	0	0
HS3ST3A1	9955	broad.mit.edu	37	17	13503904	13503904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:13503904C>T	ENST00000284110.1	-	1	1340	c.543G>A	c.(541-543)gtG>gtA	p.V181V		NM_006042.1	NP_006033.1	Q9Y663	HS3SA_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	181						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GCTCGGCGCCCACGGCGCGCA	0.721000													3	7					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111319010	111319010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111319010C>T	ENST00000308208.5	+	7	1005	c.763C>T	c.(763-765)Ctc>Ttc	p.L255F	CCDC63_ENST00000550317.1_3'UTR|CCDC63_ENST00000552694.1_Missense_Mutation_p.L176F|CCDC63_ENST00000545036.1_Missense_Mutation_p.L215F	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	255										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GCTGGAGCGTCTCTATGCCCA	0.552000													11	30					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237993860	237993860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237993860G>A	ENST00000366574.2	+	103	15003	c.14686G>A	c.(14686-14688)Gat>Aat	p.D4896N	RYR2_ENST00000542537.1_Missense_Mutation_p.D4880N|RYR2_ENST00000360064.6_Missense_Mutation_p.D4902N|RYR2_ENST00000462585.1_3'UTR	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4896					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATAGGCAATGATTACTTCGA	0.423000													18	147					0	0	1	0	0
FAM120B	84498	broad.mit.edu	37	6	170627575	170627575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:170627575C>T	ENST00000476287.1	+	2	1205	c.1097C>T	c.(1096-1098)cCc>cTc	p.P366L	FAM120B_ENST00000537664.1_Missense_Mutation_p.P389L|FAM120B_ENST00000540480.1_Missense_Mutation_p.P378L|FAM120B_ENST00000252510.9_Intron	NM_032448.1	NP_115824.1	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	366					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(2)	44		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		CGAGAAGTTCCCGTGTATACA	0.527000													78	146					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104136527	104136527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104136527C>T	ENST00000369983.3	+	32	4515	c.4255C>T	c.(4255-4257)Cgg>Tgg	p.R1419W		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1419					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CAAGACTCTCCGGATCTTTGT	0.552000													19	70					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87636167	87636167	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:87636167G>A	ENST00000376214.1	+	21	3270	c.2331_splice	c.e21-1	p.V778_splice	NTRK2_ENST00000323115.4_Splice_Site_p.V762_splice|NTRK2_ENST00000376213.1_Splice_Site_p.V762_splice|NTRK2_ENST00000277120.3_Splice_Site_p.V778_splice	NM_006180.3	NP_006171.2	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	762	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						CTCCATCCAGGTGATAGAGTG	0.527000										TSP Lung(25;0.17)			4	21					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37506752	37506752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37506752G>A	ENST00000374660.1	+	39	3501	c.3402G>A	c.(3400-3402)caG>caA	p.Q1134Q	ANKRD30A_ENST00000361713.1_Silent_p.Q1015Q|ANKRD30A_ENST00000602533.1_Silent_p.Q1015Q			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1109						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AACTTGAACAGGCTCTCAGAA	0.294000													33	33					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50468302	50468302	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50468302G>A	ENST00000331340.3	+	8	1692	c.1537G>A	c.(1537-1539)Gag>Aag	p.E513K	IKZF1_ENST00000346667.4_Missense_Mutation_p.E283K|IKZF1_ENST00000357364.4_Missense_Mutation_p.E426K|IKZF1_ENST00000439701.1_Missense_Mutation_p.E471K|IKZF1_ENST00000359197.5_Missense_Mutation_p.E471K|IKZF1_ENST00000438033.1_Missense_Mutation_p.E426K|IKZF1_ENST00000343574.5_Missense_Mutation_p.E426K|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000349824.4_Missense_Mutation_p.E370K	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	513					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AACGCGAGGGGAGCACCGCTT	0.642000			"""D,T"""	BCL6	"""ALL, DLBCL"""								8	34					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4829647	4829647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4829647G>A	ENST00000354582.6	+	51	6937	c.6587G>A	c.(6586-6588)cGa>cAa	p.R2196Q	ITPR1_ENST00000456211.2_Missense_Mutation_p.R2148Q|ITPR1_ENST00000443694.2_Missense_Mutation_p.R2196Q|ITPR1_ENST00000423119.2_Missense_Mutation_p.R2163Q|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.R2163Q|ITPR1_ENST00000302640.8_Missense_Mutation_p.R2196Q			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2211					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGATTAGACCGAACAATGGAA	0.383000													5	18					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50756563	50756563	+	Silent	SNP	G	G	A	rs75934273		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50756563G>A	ENST00000300589.2	+	8	2850	c.2745G>A	c.(2743-2745)ggG>ggA	p.G915G		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	915					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GTGACGAGGGGGCCCAGGCCC	0.517000													164	349					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031795	79031795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79031795G>A	ENST00000446378.2	+	2	7238	c.7207G>A	c.(7207-7209)Gaa>Aaa	p.E2403K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2403						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TATCACAAAGGAATCAGAGAA	0.348000													16	48					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74452007	74452007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74452007C>T	ENST00000394019.2	-	28	3603	c.3206G>A	c.(3205-3207)aGg>aAg	p.R1069K	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000359484.4_Missense_Mutation_p.R967K|SLC4A5_ENST00000358683.4_Missense_Mutation_p.R967K|SLC4A5_ENST00000357822.5_Missense_Mutation_p.R1085K|SLC4A5_ENST00000346834.4_Missense_Mutation_p.R988K|SLC4A5_ENST00000377634.4_Missense_Mutation_p.R1085K|SLC4A5_ENST00000377632.1_Missense_Mutation_p.R988K|SLC4A5_ENST00000423644.1_3'UTR|SLC4A5_ENST00000483195.1_5'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1085						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TTTTCTCTTCCTCTTCTTGTC	0.502000													50	151					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168066361	168066361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168066361G>A	ENST00000367838.1	-	5	797	c.484C>T	c.(484-486)Ccc>Tcc	p.P162S	GPR161_ENST00000539777.1_Missense_Mutation_p.P84S|GPR161_ENST00000537209.1_Missense_Mutation_p.P182S|GPR161_ENST00000546300.1_Missense_Mutation_p.P48S|GPR161_ENST00000361697.2_Missense_Mutation_p.P162S|GPR161_ENST00000367836.1_Missense_Mutation_p.P30S|GPR161_ENST00000271357.5_Missense_Mutation_p.P162S|GPR161_ENST00000367835.1_Missense_Mutation_p.P162S	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	162					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CCAAACAGGGGTGGCAGGCAG	0.572000													26	54					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82643420	82643420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:82643420C>T	ENST00000533655.1	+	6	1252	c.1040C>T	c.(1039-1041)cCc>cTc	p.P347L	C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000329143.3_Missense_Mutation_p.P46L|C11orf82_ENST00000430323.2_Missense_Mutation_p.P347L|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	347					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						ATGCGAGAGCCCCTTGAGTCA	0.408000													44	150					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929812	121929812	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:121929812G>A	ENST00000265922.3	-	8	2297	c.1836C>T	c.(1834-1836)ttC>ttT	p.F612F	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		612					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GGACCGTCTCGAAAAATGTTT	0.552000													42	86					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101365178	101365178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101365178C>T	ENST00000392979.3	+	5	807	c.446C>T	c.(445-447)cCt>cTt	p.P149L	ANO4_ENST00000392977.3_Missense_Mutation_p.P184L|ANO4_ENST00000538618.1_Missense_Mutation_p.P350L|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	184						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GTAAGAATGCCTTTCAGGTAG	0.373000										HNSCC(74;0.22)			25	72					0	0	1	0	0
LOC643733	643733	broad.mit.edu	37	11	104774135	104774135	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:104774135C>T	ENST00000532510.1	-	0	3401																											ATCACACTTTCATTTATTTCA	0.388000													8	23					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540419	133540419	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133540419G>A	ENST00000409261.1	-	14	4338	c.3965C>T	c.(3964-3966)tCt>tTt	p.S1322F	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.S1322F	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1322							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTTGTTGGGAGAGCTTTCCGT	0.612000													6	46					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142749482	142749482	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142749482C>T	ENST00000418316.1	+	1	66	c.45C>T	c.(43-45)ttC>ttT	p.F15F		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					TCTTGGGCTTCTCCTCCTTTG	0.512000													49	129					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7847058	7847058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7847058C>T	ENST00000328375.1	-	1	461	c.462G>A	c.(460-462)gtG>gtA	p.V154V	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCCAAGCATTCACACATCCAC	0.473000													36	70					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98363806	98363806	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98363806C>T	ENST00000339364.5	-	15	2290	c.2170_splice	c.e15-1	p.S724_splice	PIK3AP1_ENST00000371109.3_Splice_Site_p.S323_splice|PIK3AP1_ENST00000371110.2_Splice_Site_p.S546_splice	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	724						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		ACTTGTGCTACCTAAAGGGTA	0.453000													5	14					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171384	150171384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150171384G>A	ENST00000307271.3	+	4	1541	c.967G>A	c.(967-969)Ggc>Agc	p.G323S		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	323						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CATCTGTACAGGCCCCCATGC	0.428000													30	72					0	0	1	0	0
FAM114A1	92689	broad.mit.edu	37	4	38907180	38907180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:38907180C>T	ENST00000358869.2	+	5	650	c.474C>T	c.(472-474)gcC>gcT	p.A158A	FAM114A1_ENST00000515037.1_5'UTR	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1	158						cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						AAGCAGGAGCCACTCTACGGA	0.448000													45	137					0	0	1	0	0
SPAG7	9552	broad.mit.edu	37	17	4864089	4864089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4864089G>A	ENST00000575142.1	-	2	130	c.112C>T	c.(112-114)Cgt>Tgt	p.R38C	SPAG7_ENST00000206020.3_Missense_Mutation_p.R49C|SPAG7_ENST00000573366.1_5'UTR			O75391	SPAG7_HUMAN	sperm associated antigen 7	49						nucleus	nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(3)|ovary(2)|urinary_tract(1)	10						ACCCTTTTACGAAACTCCACT	0.468000													27	57					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8528672	8528672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8528672C>T	ENST00000381196.4	-	12	1003	c.460G>A	c.(460-462)Gat>Aat	p.D154N	PTPRD_ENST00000397611.3_Missense_Mutation_p.D154N|PTPRD_ENST00000397617.3_Missense_Mutation_p.D154N|PTPRD_ENST00000463477.1_Missense_Mutation_p.D154N|PTPRD_ENST00000540109.1_Missense_Mutation_p.D154N|PTPRD_ENST00000360074.4_Missense_Mutation_p.D154N|PTPRD_ENST00000537002.1_Missense_Mutation_p.D154N|PTPRD_ENST00000358503.5_Missense_Mutation_p.D154N|PTPRD_ENST00000486161.1_Missense_Mutation_p.D154N|PTPRD_ENST00000356435.5_Missense_Mutation_p.D154N|PTPRD_ENST00000355233.5_Missense_Mutation_p.D154N|PTPRD_ENST00000397606.3_Missense_Mutation_p.D154N	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	154	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.D154Y(3)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATTTCTGGATCCGGATTACCA	0.483000										TSP Lung(15;0.13)			15	139					0	0	1	0	0
LOC286238	286238	broad.mit.edu	37	9	91262450	91262450	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91262450G>A	ENST00000418343.2	-	0	301																											TATACATAATGAGTTATCATC	0.433000													34	101					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19765374	19765374	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19765374G>A	ENST00000357324.6	-	13	1817	c.1791C>T	c.(1789-1791)gcC>gcT	p.A597A	ATP13A1_ENST00000496082.1_5'UTR|ATP13A1_ENST00000291503.5_Silent_p.A479A	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	597					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						TCCAGTCCACGGCCGTCAGCA	0.672000													14	32					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688639	26688639	+	Missense_Mutation	SNP	C	C	T	rs151261975		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26688639C>T	ENST00000529632.2	+	2	558	c.362C>T	c.(361-363)tCg>tTg	p.S121L	SEZ6L_ENST00000360929.3_Missense_Mutation_p.S121L|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000404234.3_Missense_Mutation_p.S121L|SEZ6L_ENST00000343706.4_Missense_Mutation_p.S121L|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000248933.6_Missense_Mutation_p.S121L	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	121						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						AAACTGCCTTCGCTCAAGCAG	0.652000													9	33					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65623988	65623988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65623988G>A	ENST00000327987.4	-	8	1409	c.1158C>T	c.(1156-1158)acC>acT	p.T386T	IGDCC3_ENST00000559231.1_5'UTR	NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	386	Ig-like C2-type 4.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TTCCAGAAATGGTCAGTGTGC	0.547000													11	20					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118514600	118514600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118514600C>T	ENST00000361417.2	+	15	3371	c.2960C>T	c.(2959-2961)tCt>tTt	p.S987F	PHLDB1_ENST00000534672.1_3'UTR|PHLDB1_ENST00000524713.1_Missense_Mutation_p.S130F|PHLDB1_ENST00000356063.5_Missense_Mutation_p.S940F|PHLDB1_ENST00000527898.1_Missense_Mutation_p.S23F	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	987										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		tcctctggctcttcctcctcc	0.652000													29	43					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43847747	43847747	+	Missense_Mutation	SNP	C	C	T	rs150619594		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43847747C>T	ENST00000389420.3	-	12	1722	c.1723G>A	c.(1723-1725)Gga>Aga	p.G575R	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.G575R	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	575	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTTTCGATTCCGCCTCCACAT	0.418000													5	14					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256380	63256380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:63256380G>A	ENST00000323865.3	-	1	1400	c.1167C>T	c.(1165-1167)ggC>ggT	p.G389G	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	389					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGTTGGAGTAGCCCAGCCAAT	0.507000													60	234					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117710337	117710337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117710337C>T	ENST00000317775.6	-	10	2377	c.1692G>A	c.(1690-1692)ctG>ctA	p.L564L	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.L564L	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	564					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CGTACCACTTCAGCCCCAGGT	0.607000													15	64					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30495221	30495221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30495221G>A	ENST00000356798.6	+	8	976	c.796G>A	c.(796-798)Gag>Aag	p.E266K	ITGAL_ENST00000454514.2_3'UTR|ITGAL_ENST00000358164.5_Missense_Mutation_p.E183K|ITGAL_ENST00000433423.2_Intron|RP11-297C4.2_ENST00000569459.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	266	VWFA.				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CACGGATGGGGAGGCCACTGA	0.582000													28	185					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106693	55106693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55106693G>A	ENST00000453777.1	+	5	657	c.487G>A	c.(487-489)Gaa>Aaa	p.E163K	LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.E163K|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	163	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		AGGAGAAGATGAACACCCACA	0.587000													56	145					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328747	88328747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:88328747C>T	ENST00000325089.6	+	2	1323	c.1104C>T	c.(1102-1104)tcC>tcT	p.S368S	SLITRK5_ENST00000400028.3_Silent_p.S127S	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	368	LRRNT.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					AGACCAAATCCCCGGTGCCTT	0.597000													15	65					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24877584	24877584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24877584C>T	ENST00000382554.3	+	3	1026	c.708C>T	c.(706-708)tcC>tcT	p.S236S		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	236					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCATGGTGTCCGTGGGAGAGA	0.597000													24	98					0	0	1	0	0
SERPINA12	145264	broad.mit.edu	37	14	94962931	94962931	+	Silent	SNP	G	G	A	rs34365882	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94962931G>A	ENST00000341228.2	-	4	1479	c.684C>T	c.(682-684)ttC>ttT	p.F228F	SERPINA12_ENST00000556881.1_Silent_p.F228F	NM_173850.2	NP_776249.1	Q8IW75	SPA12_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	228					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33				COAD - Colon adenocarcinoma(157;0.235)		TCTCCAGAAAGAAATCTTCCT	0.413000													45	90					0	0	1	0	0
NCCRP1	342897	broad.mit.edu	37	19	39691306	39691306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39691306C>T	ENST00000339852.4	+	6	760	c.738C>T	c.(736-738)ttC>ttT	p.F246F		NM_001001414.1	NP_001001414.1	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	246	FBA.				protein catabolic process					kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	10						TTATCCACTTCCTGCACAAGG	0.627000													115	271					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43319820	43319820	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43319820G>A	ENST00000331495.3	+	16	2334	c.1998G>A	c.(1996-1998)gaG>gaA	p.E666E	FMNL1_ENST00000587489.1_Silent_p.E244E|FMNL1_ENST00000328118.3_Silent_p.E666E	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	666	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						TCAATGATGAGAAGGTGCTGC	0.582000													15	25					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394265	164394265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164394265C>T	ENST00000280605.3	-	1	782	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	208						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCAAAGGCTTCACAGCAATTC	0.517000													19	88					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2421882	2421882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2421882G>A	ENST00000332578.3	+	13	2083	c.2083G>A	c.(2083-2085)Gag>Aag	p.E695K		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	695	Peptidase S1 2.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCTGCGAGGAGGCCCCTGG	0.612000													44	67					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168138055	168138055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168138055C>T	ENST00000519560.1	-	25	2983	c.2564G>A	c.(2563-2565)gGa>gAa	p.G855E	SLIT3_ENST00000332966.8_Missense_Mutation_p.G855E|SLIT3_ENST00000404867.3_Missense_Mutation_p.G855E|CTC-558O2.1_ENST00000522615.1_RNA	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	855					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGGTTGGTTCCCAGCGCCCT	0.597000													3	11					0	0	1	0	0
NKD1	85407	broad.mit.edu	37	16	50667441	50667441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50667441C>T	ENST00000268459.3	+	10	1386	c.1162C>T	c.(1162-1164)Ccg>Tcg	p.P388S		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	388					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GGCTGCCAGCCCGGCCCTCCT	0.716000													4	22					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94056584	94056584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94056584C>T	ENST00000297268.6	+	48	3715	c.3244C>T	c.(3244-3246)Cct>Tct	p.P1082S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	1082					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CATTCGAGGCCCTCAGGGTCA	0.502000										HNSCC(75;0.22)			7	11					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50823956	50823956	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50823956T>C	ENST00000391818.2	-	2	132	c.74A>G	c.(73-75)aAg>aGg	p.K25R	KCNC3_ENST00000376959.2_Silent_p.E688E|KCNC3_ENST00000474951.1_Silent_p.E4E|KCNC3_ENST00000477616.1_Silent_p.E688E			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	649					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GGCTCTTGTCTTCCGGGGACA	0.657000													12	39					0	0	1	0	0
TCEA3	6920	broad.mit.edu	37	1	23724045	23724045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23724045G>A	ENST00000450454.2	-	7	763	c.657C>T	c.(655-657)atC>atT	p.I219I		NM_003196.1	NP_003187.1	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	219	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		TATGATCTTCGATTTCTGATG	0.498000													33	67					0	0	1	0	0
IQCF1	132141	broad.mit.edu	37	3	51937085	51937085	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51937085C>T	ENST00000310914.5	-	2	86	c.24G>A	c.(22-24)aaG>aaA	p.K8K		NM_152397.2	NP_689610.2	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	8										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GTTCCTTCGTCTTTTGGGGCT	0.537000													104	294					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236205563	236205563	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236205563C>T	ENST00000264187.6	-	4	864	c.782G>A	c.(781-783)tGg>tAg	p.W261*	NID1_ENST00000366595.3_Nonsense_Mutation_p.W261*	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	261	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CTCAAACACCCAGACACCCTG	0.552000													69	228					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108367771	108367771	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108367771A>T	ENST00000361582.3	+	17	2199	c.1969A>T	c.(1969-1971)Agt>Tgt	p.S657C	DZIP3_ENST00000463306.1_Missense_Mutation_p.S657C	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	657					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						CTAGGTTAAGAGTAAACAAAG	0.264000													4	21					0	0	1	0	0
CYP39A1	51302	broad.mit.edu	37	6	46604135	46604135	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46604135A>C	ENST00000275016.2	-	5	926	c.723T>G	c.(721-723)gaT>gaG	p.D241E		NM_016593.3	NP_057677.2	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A, polypeptide 1	241					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity		EIF3K/CYP39A1(2)	NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)	21						CCATGGAATTATCTTTTGCAG	0.274000													16	56					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291465	33291465	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:33291465G>A	ENST00000280979.4	+	13	4616	c.4446G>A	c.(4444-4446)atG>atA	p.M1482I	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1482					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AATTACCAATGATAATGAAAC	0.358000													21	52					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175105061	175105061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175105061G>A	ENST00000239462.4	+	16	3524	c.3411G>A	c.(3409-3411)atG>atA	p.M1137I		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1137	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGGACCCCATGAAGGAGTTCT	0.542000													32	73					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18113038	18113038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18113038C>T	ENST00000403915.1	+	3	1214	c.763C>T	c.(763-765)Ctg>Ttg	p.L255L	KCNS3_ENST00000304101.4_Silent_p.L255L|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	255					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GAAAAACCCTCTGAACATCAT	0.512000													31	136					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80782861	80782861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:80782861C>T	ENST00000466387.1	+	16	2308	c.1584C>T	c.(1582-1584)ctC>ctT	p.L528L	CTNNA2_ENST00000402739.4_Silent_p.L528L|CTNNA2_ENST00000361291.4_Silent_p.L562L|CTNNA2_ENST00000496558.1_Silent_p.L528L|CTNNA2_ENST00000540488.1_Silent_p.L528L|CTNNA2_ENST00000343114.3_Silent_p.L207L|CTNNA2_ENST00000541047.1_Silent_p.L528L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	528					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TGATAGCCCTCCAAGAGGGCG	0.483000													29	84					0	0	1	0	0
ZNF701	55762	broad.mit.edu	37	19	53085871	53085871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53085871C>T	ENST00000540331.1	+	5	982	c.757C>T	c.(757-759)Cgt>Tgt	p.R253C	CTD-3099C6.7_ENST00000599222.1_RNA|ZNF701_ENST00000391785.3_Missense_Mutation_p.R187C|ZNF701_ENST00000301093.2_Missense_Mutation_p.R253C	NM_001172655.1	NP_001166126.1	Q9NV72	ZN701_HUMAN	zinc finger protein 701	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(6)	14				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		GCCAAAAACTCGTATTTCTAA	0.383000													33	68					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89650505	89650505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89650505G>A	ENST00000268720.5	+	6	857	c.727G>A	c.(727-729)Gac>Aac	p.D243N	CPNE7_ENST00000319518.8_Missense_Mutation_p.D168N	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	243	C2 2.				lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GAAGCTGGACGACAAGGTGAG	0.677000													6	48					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25467363	25467363	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25467363C>T	ENST00000424208.1	+	0	3097				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						CAGTGTCCATCATCCAGGTGC	0.582000													11	32					0	0	1	0	0
GAL3ST4	79690	broad.mit.edu	37	7	99758461	99758461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99758461G>A	ENST00000360039.4	-	4	943	c.551C>T	c.(550-552)tCt>tTt	p.S184F	GAL3ST4_ENST00000423751.1_Missense_Mutation_p.L83F|GAL3ST4_ENST00000413800.1_Missense_Mutation_p.S184F|GAL3ST4_ENST00000411994.1_Missense_Mutation_p.L83F|GAL3ST4_ENST00000426974.2_Missense_Mutation_p.S122F	NM_024637.4	NP_078913.3	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	184					cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(5)|prostate(1)|upper_aerodigestive_tract(1)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGCAGCCAAAGATGGTGACTT	0.562000													27	78					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182781010	182781010	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182781010C>T	ENST00000431877.2	+	11	2822	c.2643C>T	c.(2641-2643)ttC>ttT	p.F881F	SSFA2_ENST00000320370.7_Silent_p.F881F|SSFA2_ENST00000428267.2_Silent_p.F728F|SSFA2_ENST00000409136.1_Silent_p.F390F|SSFA2_ENST00000409001.1_Silent_p.F881F	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	881						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			GTAGTGCCTTCGCTTCCCCTT	0.517000													11	103					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169511109	169511109	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169511109G>A	ENST00000367796.3	-	13	3435	c.3234C>T	c.(3232-3234)tcC>tcT	p.S1078S	F5_ENST00000367797.3_Silent_p.S1073S			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1073	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATGTTTCATTGGATTTATGAA	0.423000													77	266					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145627710	145627710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:145627710C>T	ENST00000296575.3	+	5	1514	c.859C>T	c.(859-861)Ctc>Ttc	p.L287F		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	287						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		ACTGCTAAGCCTCGCATTCCA	0.413000													16	26					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20625847	20625847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20625847G>A	ENST00000525748.1	+	3	829	c.556G>A	c.(556-558)Gat>Aat	p.D186N		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	186					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CGAGCAAGGGGATGAGAATAA	0.607000													44	112					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120135468	120135468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120135468G>A	ENST00000392521.2	-	46	5933	c.5878C>T	c.(5878-5880)Cgc>Tgc	p.R1960C	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.R1918C	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1918					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GGTTACCTGCGGGAGGTGGAC	0.527000													32	132					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18322637	18322637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18322637C>T	ENST00000355502.3	-	18	2594	c.1723G>A	c.(1723-1725)Gag>Aag	p.E575K	PDE4C_ENST00000594465.2_Missense_Mutation_p.E575K|PDE4C_ENST00000262805.11_Missense_Mutation_p.E543K|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000539010.1_Missense_Mutation_p.E344K|PDE4C_ENST00000447275.2_Missense_Mutation_p.E469K|PDE4C_ENST00000594617.2_Missense_Mutation_p.E575K			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	575					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GACTCACGCTCGCGGTCTCCC	0.627000													37	74					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106769947	106769947	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:106769947G>A	ENST00000276185.4	+	3	228	c.228G>A	c.(226-228)gtG>gtA	p.V76V	FRMPD3-AS1_ENST00000415252.1_RNA			Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	76	PDZ.					cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GGCCTGTGGTGGTTCGATCTG	0.552000													27	35					0	0	1	0	0
PGAM2	5224	broad.mit.edu	37	7	44102378	44102378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44102378C>T	ENST00000297283.3	-	3	804	c.747G>A	c.(745-747)caG>caA	p.Q249Q		NM_000290.3	NP_000281.2	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2 (muscle)	249					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity			large_intestine(2)|lung(4)|ovary(1)|stomach(1)	8						TGGCCTTGCCCTGGGCAGCCA	0.617000													4	42					0	0	1	0	0
PGM2	55276	broad.mit.edu	37	4	37831637	37831637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:37831637G>A	ENST00000381967.4	+	2	233	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	PGM2_ENST00000537241.1_5'UTR|PGM2_ENST00000544359.1_5'UTR	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	45					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						AGGTAATAAAGAAGAACTACG	0.418000													30	61					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33236535	33236535	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33236535G>A	ENST00000401073.2	+	6	1825	c.1755G>A	c.(1753-1755)tcG>tcA	p.S585S	KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373481.3_Silent_p.S537S|KIAA1522_ENST00000373480.1_Silent_p.S526S	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	526	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GTGGATACTCGAGCCAAAGTG	0.662000													20	32					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476860	20476860	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20476860C>T	ENST00000573854.1	+	3	313	c.199C>T	c.(199-201)Cca>Tca	p.P67S	ACSM2A_ENST00000417235.2_5'UTR|ACSM2A_ENST00000536134.1_5'UTR|ACSM2A_ENST00000396104.2_Missense_Mutation_p.P67S|ACSM2A_ENST00000219054.6_Missense_Mutation_p.P67S|ACSM2A_ENST00000424070.1_Missense_Mutation_p.P67S|ACSM2A_ENST00000575690.1_Missense_Mutation_p.P67S|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	67					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						ACTCCCAAGCCCAGCCCTGTG	0.537000													18	55					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33134870	33134870	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33134870C>T	ENST00000341947.2	-	58	4434	c.4207G>A	c.(4207-4209)Gat>Aat	p.D1403N	COL11A2_ENST00000374714.1_Missense_Mutation_p.D1377N|COL11A2_ENST00000361917.1_Missense_Mutation_p.D1296N|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000395197.1_Missense_Mutation_p.D1343N|COL11A2_ENST00000374713.1_Missense_Mutation_p.D1356N|COL11A2_ENST00000374712.1_Missense_Mutation_p.D1322N|COL11A2_ENST00000374708.4_Missense_Mutation_p.D1317N|COL11A2_ENST00000357486.1_Missense_Mutation_p.D1382N	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1403	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GCTCCAGCATCGCCCCGGAGA	0.612000													8	68					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66816097	66816097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66816097G>A	ENST00000393946.2	+	11	2297	c.1135G>A	c.(1135-1137)Ggc>Agc	p.G379S	SYT12_ENST00000527043.1_Missense_Mutation_p.G379S|SYT12_ENST00000525457.1_Missense_Mutation_p.G379S			Q8IV01	SYT12_HUMAN	synaptotagmin XII	379	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						CAGCAGCGACGGCCGTGGGGA	0.627000													30	53					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43522383	43522383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43522383C>T	ENST00000400427.1	+	8	1474	c.1078C>T	c.(1078-1080)Cac>Tac	p.H360Y	C21orf128_ENST00000329015.2_3'UTR|UMODL1_ENST00000408989.2_Missense_Mutation_p.H432Y|UMODL1_ENST00000400424.1_Missense_Mutation_p.H360Y|UMODL1_ENST00000408910.2_Missense_Mutation_p.H432Y	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	432	Fibronectin type-III 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						ACAACTGCTTCACGAGGTAAA	0.458000													19	58					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4732836	4732836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4732836G>A	ENST00000354582.6	+	32	4187	c.3837G>A	c.(3835-3837)gaG>gaA	p.E1279E	ITPR1_ENST00000456211.2_Silent_p.E1255E|ITPR1_ENST00000443694.2_Silent_p.E1264E|ITPR1_ENST00000423119.2_Silent_p.E1270E|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Silent_p.E1270E|ITPR1_ENST00000302640.8_Silent_p.E1264E			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1279					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGATCCTGGAGGCAGTAACCA	0.443000													3	22					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30926222	30926222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30926222G>A	ENST00000383096.3	-	9	793	c.611C>T	c.(610-612)tCt>tTt	p.S204F	CCDC178_ENST00000406524.2_Missense_Mutation_p.S204F|CCDC178_ENST00000300227.8_Missense_Mutation_p.S204F|CCDC178_ENST00000579947.1_Missense_Mutation_p.S204F|CCDC178_ENST00000402325.1_Missense_Mutation_p.S204F|CCDC178_ENST00000583930.1_Missense_Mutation_p.S204F|CCDC178_ENST00000403303.1_Missense_Mutation_p.S204F|CCDC178_ENST00000579916.1_Intron					coiled-coil domain containing 178																		GACTGACCAAGAGTCAATTTT	0.368000													34	102					0	0	1	0	0
OR5AU1	390445	broad.mit.edu	37	14	21624046	21624046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21624046C>T	ENST00000304418.3	-	1	176	c.139G>A	c.(139-141)Gag>Aag	p.E47K		NM_001004731.1	NP_001004731.1	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU, member 1	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(12)|pancreas(1)	21	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		CTCCAGTGCTCTGCGATGGAG	0.532000													38	90					0	0	1	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46387758	46387758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46387758G>A	ENST00000302165.3	-	1	1618	c.1275C>T	c.(1273-1275)gcC>gcT	p.A425A		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CATTCTTCAGGGCGGCAATGG	0.711000													14	37					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13729486	13729486	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:13729486T>C	ENST00000354817.3	+	4	549	c.405T>C	c.(403-405)ctT>ctC	p.L135L		NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	135					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						CGCGACAGCTTATTCTCCTTG	0.353000													22	53					0	0	1	0	0
HRASLS2	54979	broad.mit.edu	37	11	63320447	63320447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63320447C>T	ENST00000255695.1	-	4	536	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K		NM_017878.1	NP_060348.1	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	160					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6						TATTGCCTTTCCCGCTTGCTT	0.512000													14	57					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14284465	14284465	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:14284465G>A	ENST00000310358.7	+	0	2739				RP11-21L19.1_ENST00000534587.1_RNA			Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AGGGAGGCCCGAGAGAGCCGG	0.592000													16	39					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64335111	64335111	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64335111C>T	ENST00000301891.4	+	7	1473	c.1099C>T	c.(1099-1101)Ctg>Ttg	p.L367L	SLC22A11_ENST00000377585.3_Intron|SLC22A11_ENST00000377581.3_Silent_p.L367L	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	367					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	GGTCTTCGACCTGCAGAGCCT	0.632000													62	133					0	0	1	0	0
SYPL2	284612	broad.mit.edu	37	1	110018217	110018217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110018217C>T	ENST00000369872.3	+	3	360	c.144C>T	c.(142-144)ttC>ttT	p.F48F	SYPL2_ENST00000475497.1_3'UTR|SYPL2_ENST00000401021.3_Silent_p.F48F	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	48	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		TTGCTATTTTCGCCTTCGGGT	0.547000													20	57					0	0	1	0	0
RPS6KL1	83694	broad.mit.edu	37	14	75388145	75388145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75388145G>A	ENST00000555647.1	-	3	387	c.100C>T	c.(100-102)Cgc>Tgc	p.R34C	RPS6KL1_ENST00000557413.1_Missense_Mutation_p.R34C|RPS6KL1_ENST00000358328.4_Missense_Mutation_p.R34C|RPS6KL1_ENST00000354625.2_Missense_Mutation_p.R34C|RPS6KL1_ENST00000554900.1_Intron			Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	34						ribosome	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(234;0.00658)		ACCCTGTTGCGAATCTGCTCC	0.627000													14	136					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356729	37356729	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:37356729G>A	ENST00000217420.1	+	2	1288	c.1025G>A	c.(1024-1026)tGg>tAg	p.W342*		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	342					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	ATGATGAACTGGACGCACATC	0.592000													15	47					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555713	155555713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:155555713C>T	ENST00000295101.2	+	1	903	c.426C>T	c.(424-426)gcC>gcT	p.A142A	KCNJ3_ENST00000544049.1_Silent_p.A142A	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	142					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding	p.A142A(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	AGACGGAGGCCACCATCGGCT	0.572000													20	52					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027387	55027387	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:55027387C>T	ENST00000371336.3	+	5	1356	c.1155C>T	c.(1153-1155)tcC>tcT	p.S385S	CASS4_ENST00000360314.3_Silent_p.S385S|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	385	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CATGGTTCTCCAGACGGACAA	0.537000													11	31					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8807884	8807884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8807884G>A	ENST00000324436.3	-	1	1288	c.1168C>T	c.(1168-1170)Ctg>Ttg	p.L390L		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	390						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						AAGGCGCGCAGGGAGGCCAGG	0.647000													22	50					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110980464	110980464	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110980464C>T	ENST00000524391.1	-	4	2388	c.1356G>A	c.(1354-1356)aaG>aaA	p.K452K	KCNV1_ENST00000297404.1_Silent_p.K452K			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	452						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TGGTAAGCTTCTTTAGGGCTT	0.448000													20	54					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59221500	59221500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:59221500G>A	ENST00000262717.4	+	12	2376	c.1978G>A	c.(1978-1980)Gag>Aag	p.E660K	CDH20_ENST00000536675.2_Missense_Mutation_p.E660K|CDH20_ENST00000538374.1_Missense_Mutation_p.E660K			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	660					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				AAACATCCACGAGAACATCGT	0.612000													51	162					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48167728	48167728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48167728C>T	ENST00000311303.3	-	7	1343	c.998G>A	c.(997-999)aGa>aAa	p.R333K	ABCC12_ENST00000416054.1_Missense_Mutation_p.R333K|ABCC12_ENST00000448542.1_Missense_Mutation_p.R333K	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	333	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CAGTAATTTTCTTTCCCTCCT	0.443000													19	45					0	0	1	0	0
POLG2	11232	broad.mit.edu	37	17	62487002	62487002	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62487002G>A	ENST00000539111.2	-	4	947	c.880C>T	c.(880-882)Ccc>Tcc	p.P294S		NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	294					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding	p.P294S(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			TTTCCCCAGGGAAAATTGTAG	0.398000													40	71					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215301392	215301392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215301392G>A	ENST00000312504.5	+	3	1232	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	AC107218.3_ENST00000437883.1_RNA|AC107218.3_ENST00000412896.1_RNA|VWC2L_ENST00000427124.1_Intron	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	144	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						GCCCAGCAATGAAGTTCACTG	0.443000													12	47					0	0	1	0	0
POLDIP3	84271	broad.mit.edu	37	22	42981873	42981873	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42981873G>A	ENST00000252115.5	-	9	1294	c.1190C>T	c.(1189-1191)aCc>aTc	p.T397I	POLDIP3_ENST00000451060.2_3'UTR|POLDIP3_ENST00000348657.2_Missense_Mutation_p.T368I|POLDIP3_ENST00000339677.6_Intron	NM_032311.3	NP_115687.2	Q9BY77	PDIP3_HUMAN	polymerase (DNA-directed), delta interacting protein 3	397					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	16						CTTCAGGATGGTGTCAGGGTC	0.582000													44	91					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9581067	9581067	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9581067C>T	ENST00000301480.4	-	7	662		c.e7+1			NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						GCCAGACTTACCTACTGAGGA	0.438000													27	127					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53215798	53215798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53215798G>A	ENST00000330553.5	-	9	1500	c.1466C>T	c.(1465-1467)tCc>tTc	p.S489F		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	489	Tail.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCCACCCAGGGAGATGCCACC	0.622000													13	57					0	0	1	0	0
FAM188B	84182	broad.mit.edu	37	7	30898886	30898886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30898886C>T	ENST00000265299.6	+	13	1768	c.1691C>T	c.(1690-1692)cCc>cTc	p.P564L	AQP1_ENST00000434909.2_5'UTR|INMT-FAM188B_ENST00000458257.1_3'UTR|AQP1_ENST00000509504.1_Missense_Mutation_p.P27L	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	564										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GAAGTGGGCCCCTATGGCTGC	0.592000													13	86					0	0	1	0	0
CRX	1406	broad.mit.edu	37	19	48343035	48343035	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48343035C>T	ENST00000221996.7	+	4	917	c.711C>T	c.(709-711)ctC>ctT	p.L237L	CRX_ENST00000539067.1_Silent_p.L237L|TPRX2P_ENST00000535362.1_Intron	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	237					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		TTAGCCCCCTCTCTGGCCCCT	0.652000													23	250					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10323457	10323457	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10323457G>A	ENST00000403437.2	-	3	182	c.88C>T	c.(88-90)Caa>Taa	p.Q30*	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	30	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GGCTTGTTTTGGGCCTCAATC	0.478000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				78	103					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14543004	14543004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14543004C>T	ENST00000358970.5	-	1	141	c.142G>A	c.(142-144)Gac>Aac	p.D48N	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	48										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TCGTCGTGGTCTCCAGAAGTG	0.587000													58	299					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49087283	49087283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49087283G>A	ENST00000261900.3	-	9	1936	c.1714C>T	c.(1714-1716)Cgt>Tgt	p.R572C		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	572	Ser-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						CCCCTTTTACGAGTAGAACTG	0.443000													46	121					0	0	1	0	0
FOXL1	2300	broad.mit.edu	37	16	86612425	86612425	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:86612425C>T	ENST00000320241.3	+	1	311	c.96C>T	c.(94-96)ttC>ttT	p.F32F		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	32					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						CTCTGGCCTTCGCCCCCGCGG	0.692000													13	58					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	120053765	120053765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:120053765G>A	ENST00000313400.4	-	2	570	c.470C>T	c.(469-471)tCg>tTg	p.S157L	ASTN2_ENST00000373996.3_Missense_Mutation_p.S157L|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.S157L			O75129	ASTN2_HUMAN	astrotactin 2	157						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GTGCACCAGCGAGATGTCCGC	0.627000													11	38					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332740	71332740	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71332740G>A	ENST00000242462.4	-	2	89	c.60C>T	c.(58-60)tcC>tcT	p.S20S		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	20					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						CTCTGGGGAAGGACCGCTCCG	0.672000													24	62					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377563	113377563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113377563G>A	ENST00000316407.4	-	7	3376	c.2966C>T	c.(2965-2967)tCa>tTa	p.S989L	KIAA2018_ENST00000478658.1_Missense_Mutation_p.S989L|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	989					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGTATCTGATGAATCTTGCTC	0.393000													41	145					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70530586	70530586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70530586G>A	ENST00000357887.3	-	3	2598	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F	SLC8A3_ENST00000528359.1_Silent_p.F615F|SLC8A3_ENST00000216568.7_Intron|SLC8A3_ENST00000534137.1_Intron|SLC8A3_ENST00000533541.1_Intron|SLC8A3_ENST00000356921.2_Intron|SLC8A3_ENST00000381269.2_Intron|SLC8A3_ENST00000394330.2_Intron	NM_033262.3	NP_150287.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	615	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCATCTCAATGAAGTAATTCT	0.398000													26	79					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	769447	769447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:769447C>T	ENST00000297440.6	+	2	763	c.743C>T	c.(742-744)tCc>tTc	p.S248F	HEATR2_ENST00000438961.1_3'UTR|HEATR2_ENST00000313147.5_Missense_Mutation_p.S248F	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	248							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		GACGTGCTTTCCCATTTTGCT	0.572000													18	37					0	0	1	0	0
SGPP2	130367	broad.mit.edu	37	2	223423135	223423135	+	Missense_Mutation	SNP	G	G	A	rs141548793	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:223423135G>A	ENST00000321276.7	+	5	804	c.718G>A	c.(718-720)Gac>Aac	p.D240N		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	240					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		GACCTTCATCGACTGCCTGGA	0.537000													48	131					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146536809	146536809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:146536809G>A	ENST00000361727.3	+	3	731	c.215G>A	c.(214-216)gGg>gAg	p.G72E		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	72	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCAGGTGCTGGGGGATGGTCT	0.423000										HNSCC(39;0.1)			11	50					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515551	140515551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140515551C>T	ENST00000231134.5	+	1	752	c.535C>T	c.(535-537)Cat>Tat	p.H179Y		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		179	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCACACTTTCATGTTGCTAC	0.507000													33	83					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24366209	24366209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24366209C>T	ENST00000005284.3	+	3	1553	c.351C>T	c.(349-351)ttC>ttT	p.F117F		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	117					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.F117F(1)		NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		TGCTGTTCTTCGGCGGGCTCT	0.617000													17	42					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49690103	49690103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49690103G>A	ENST00000296452.4	+	5	3228	c.3114G>A	c.(3112-3114)gaG>gaA	p.E1038E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1038					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCACCATCGAGGACTCCTCAG	0.662000													17	26					0	0	1	0	0
TREH	11181	broad.mit.edu	37	11	118529660	118529660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118529660C>T	ENST00000529101.1	-	13	1544	c.1499G>A	c.(1498-1500)cGa>cAa	p.R500Q	TREH_ENST00000264029.4_Missense_Mutation_p.R500Q|TREH_ENST00000397925.1_Missense_Mutation_p.R469Q|TREH_ENST00000530256.1_Missense_Mutation_p.R377Q|TREH_ENST00000525958.1_Missense_Mutation_p.R469Q			O43280	TREA_HUMAN	trehalase (brush-border membrane glycoprotein)	500					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity	p.R500P(1)		NS(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		AAAATTGGTTCGGATCCAATT	0.587000													67	139					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600089	92600089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92600089C>T	ENST00000298047.6	+	21	11858	c.11841C>T	c.(11839-11841)ttC>ttT	p.F3947F	FAT3_ENST00000525166.1_Silent_p.F3797F|FAT3_ENST00000533797.1_Silent_p.F282F|FAT3_ENST00000409404.2_Silent_p.F3947F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3947	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCCTCTACTTCCAGACGCTGA	0.632000										TCGA Ovarian(4;0.039)			6	27					0	0	1	0	0
C6orf195	154386	broad.mit.edu	37	6	2624022	2624022	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:2624022G>A	ENST00000296847.3	-	3	558	c.35C>T	c.(34-36)cCc>cTc	p.P12L		NM_152554.2	NP_689767.2	Q96MT4	CF195_HUMAN	chromosome 6 open reading frame 195	12										cervix(1)|endometrium(1)|lung(2)|skin(1)	5	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				CTGCTTCCAGGGAATGTTCCT	0.507000													13	53					0	0	1	0	0
CHST4	10164	broad.mit.edu	37	16	71571673	71571673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71571673G>A	ENST00000338482.5	+	3	1436	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K	CHST4_ENST00000539698.3_Missense_Mutation_p.E365K|RP11-510M2.9_ENST00000572693.1_RNA|CHST4_ENST00000572450.1_Missense_Mutation_p.E365K|ZNF19_ENST00000568446.1_Intron			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	365					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						CGTCAGATCTGAACAAGAACA	0.522000											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	71					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53617456	53617456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:53617456G>A	ENST00000342160.3	-	34	4556	c.4099C>T	c.(4099-4101)Ctc>Ttc	p.L1367F	HUWE1_ENST00000262854.6_Missense_Mutation_p.L1367F|HUWE1_ENST00000218328.8_Missense_Mutation_p.L1367F			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1367					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GACATGCTGAGATCCTAGAGT	0.438000													11	54					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18671986	18671986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18671986C>T	ENST00000308799.4	+	9	2150	c.1931C>T	c.(1930-1932)cCc>cTc	p.P644L	FBXW10_ENST00000395667.1_Missense_Mutation_p.P615L|FBXW10_ENST00000301938.4_Missense_Mutation_p.P615L|FBXW10_ENST00000395665.4_Missense_Mutation_p.P615L			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	615										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						TTCAAGCATCCCAAGTAGGTG	0.567000													24	16					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169696610	169696610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169696610C>T	ENST00000333360.7	-	10	1664	c.1525G>A	c.(1525-1527)Gag>Aag	p.E509K	SELE_ENST00000367780.4_Missense_Mutation_p.E384K|SELE_ENST00000367781.4_Missense_Mutation_p.E446K|SELE_ENST00000367779.4_Missense_Mutation_p.E383K|SELE_ENST00000367782.4_Missense_Mutation_p.E446K|SELE_ENST00000367777.1_Missense_Mutation_p.E446K|SELE_ENST00000367775.1_Missense_Mutation_p.E384K|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367776.1_Missense_Mutation_p.E446K|SELE_ENST00000367774.1_Missense_Mutation_p.E383K	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	509	Sushi 6.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					AACACGGGCTCCCCACTGCAG	0.522000													16	47					0	0	1	0	0
H1FOO	132243	broad.mit.edu	37	3	129267879	129267879	+	Silent	SNP	G	G	A	rs145471008		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129267879G>A	ENST00000324382.2	+	3	419	c.414G>A	c.(412-414)agG>agA	p.R138R	H1FOO_ENST00000503977.1_5'UTR	NM_153833.1	NP_722575.1	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	138					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding	p.R138R(1)		endometrium(1)|lung(4)|skin(1)	6						TCCAGCCCAGGAAGATGGCCC	0.647000													5	30					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21035984	21035984	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21035984C>T	ENST00000261383.3	-	39	5579	c.5580G>A	c.(5578-5580)tgG>tgA	p.W1860*	DNAH3_ENST00000415178.1_Nonsense_Mutation_p.W1860*	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1860	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCAGGGGCTTCCAGCCTAGTT	0.532000													4	47					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152383212	152383212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152383212C>T	ENST00000271835.3	-	3	408	c.346G>A	c.(346-348)Gga>Aga	p.G116R	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	116					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTCTCTGTCCTTCGCCCAGC	0.617000													159	301					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091556	9091556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9091556G>A	ENST00000397910.4	-	1	462	c.259C>T	c.(259-261)Cct>Tct	p.P87S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	87	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGACTCAGGGAGAGCAGAG	0.537000													40	80					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45540982	45540982	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45540982C>T	ENST00000221452.8	+	12	1824	c.1674C>T	c.(1672-1674)ttC>ttT	p.F558F	RELB_ENST00000505236.1_Silent_p.F555F|RELB_ENST00000540120.1_Silent_p.F558F	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	558						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		GCAACATGTTCCCCAATCATT	0.697000													5	27					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35400426	35400426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35400426C>T	ENST00000378495.3	+	36	4445	c.4223C>T	c.(4222-4224)tCg>tTg	p.S1408L	UNC13B_ENST00000396787.1_Missense_Mutation_p.S1420L|UNC13B_ENST00000378496.4_Missense_Mutation_p.S1408L	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	1408					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity	p.S1408*(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TTTGTGCGCTCGCAGACCACC	0.527000													70	121					0	0	1	0	0
GTF2H3	2967	broad.mit.edu	37	12	124135583	124135583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124135583C>T	ENST00000543341.2	+	5	438	c.407C>T	c.(406-408)tCc>tTc	p.S136F	GTF2H3_ENST00000228955.7_Missense_Mutation_p.S95F	NM_001271867.1|NM_001516.3	NP_001258796.1|NP_001507.2	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3, 34kDa	136					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		CTGGCAGGATCCCTGGCCAAA	0.368000								Nucleotide excision repair (NER)					23	44					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1507763	1507763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1507763C>T	ENST00000345913.4	+	14	2521	c.2430C>T	c.(2428-2430)gcC>gcT	p.A810A	TPO_ENST00000497517.2_3'UTR|TPO_ENST00000349624.3_Silent_p.A637A|TPO_ENST00000382198.1_Silent_p.A637A|TPO_ENST00000337415.3_Silent_p.A810A|TPO_ENST00000382201.3_Silent_p.A753A|TPO_ENST00000329066.4_Silent_p.A810A|TPO_ENST00000346956.3_Intron	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	810	EGF-like; calcium-binding (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCTGCCACGCCTCTGCGAGGT	0.627000													21	43					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4445806	4445806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4445806G>A	ENST00000254718.4	-	22	3346	c.3040C>T	c.(3040-3042)Ccc>Tcc	p.P1014S	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.P1014S			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	1014					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						ACCAGGATGGGGAGCAGGCTC	0.637000													32	40					0	0	1	0	0
TRAJ9	28746	broad.mit.edu	37	14	23004532	23004532	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23004532G>A	ENST00000390528.1	+	0	31																											AACTATCTTTGGAGCAGGAAC	0.373000													13	60					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16242248	16242248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:16242248G>A	ENST00000339732.5	+	3	1332	c.829G>A	c.(829-831)Gat>Aat	p.D277N	GALNT15_ENST00000437509.1_Missense_Mutation_p.D277N	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		AGCCACCGGGGATGTGCTCGT	0.622000													17	30					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105797580	105797580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:105797580C>T	ENST00000393127.2	+	13	2407	c.1961C>T	c.(1960-1962)cCc>cTc	p.P654L	GRIA4_ENST00000530497.1_Missense_Mutation_p.P654L|GRIA4_ENST00000525187.1_Missense_Mutation_p.P654L|GRIA4_ENST00000282499.5_Missense_Mutation_p.P654L	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	654					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity	p.P654L(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATGGTCTCTCCCATAGAAAGT	0.418000													14	52					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123843062	123843062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123843062C>T	ENST00000369005.1	+	4	1387	c.1047C>T	c.(1045-1047)ggC>ggT	p.G349G	TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Silent_p.G349G|TACC2_ENST00000334433.3_Silent_p.G349G|TACC2_ENST00000515273.1_Silent_p.G349G|TACC2_ENST00000453444.2_Silent_p.G349G	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	349						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGCCCTGGGGCTTGCCAAGTC	0.627000													22	65					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31565099	31565099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31565099C>T	ENST00000379416.3	-	32	3517	c.3469G>A	c.(3469-3471)Ggg>Agg	p.G1157R		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	1157					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CAAGCCACCCCATAGCTGAAG	0.443000													37	97					0	0	1	0	0
GNGT2	2793	broad.mit.edu	37	17	47284190	47284190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47284190C>T	ENST00000511277.1	-	4	318	c.139G>A	c.(139-141)Gat>Aat	p.D47N	GNGT2_ENST00000515635.1_Missense_Mutation_p.D47N|GNGT2_ENST00000300406.2_Missense_Mutation_p.D47N|GNGT2_ENST00000503070.1_Missense_Mutation_p.D47N|GNGT2_ENST00000511673.1_Missense_Mutation_p.D47N|GNGT2_ENST00000507680.1_Missense_Mutation_p.D47N	NM_001198756.1	NP_001185685.1	O14610	GBGT2_HUMAN	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	47					G-protein coupled receptor protein signaling pathway|phototransduction|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity			endometrium(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			AGAAAAGGATCGTTTCCTGCT	0.488000													28	90					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80366371	80366371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:80366371G>A	ENST00000265080.4	+	4	671	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	202					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CCAAGAAGACGAAGATCCAGA	0.428000													35	80					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55452895	55452895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55452895G>A	ENST00000588756.1	-	4	671	c.185C>T	c.(184-186)tCc>tTc	p.S62F	NLRP7_ENST00000328092.5_Missense_Mutation_p.S62F|NLRP7_ENST00000340844.2_Missense_Mutation_p.S62F|NLRP7_ENST00000448121.2_Missense_Mutation_p.S62F|NLRP7_ENST00000590030.1_Missense_Mutation_p.S62F|NLRP7_ENST00000592784.1_Missense_Mutation_p.S62F|NLRP7_ENST00000446217.1_Missense_Mutation_p.S90F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	62	DAPIN.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		ATTTTCTGAGGAGGTGTTGAC	0.468000													40	76					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420603	53420603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:53420603C>T	ENST00000377942.3	-	1	2172	c.1969G>A	c.(1969-1971)Gag>Aag	p.E657K	PCDH8_ENST00000338862.4_Missense_Mutation_p.E657K	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	657	Cadherin 6.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TCGCGCGGCTCCTGCTGCTGC	0.711000													13	24					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105174066	105174066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105174066C>T	ENST00000369797.3	+	11	1444	c.1350C>T	c.(1348-1350)atC>atT	p.I450I		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	450					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ATCATGACATCGAACCTGGGG	0.443000													18	37					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86049712	86049712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:86049712C>T	ENST00000414626.2	+	14	3172	c.2283C>T	c.(2281-2283)gcC>gcT	p.A761A	LRRCC1_ENST00000360375.3_Silent_p.A781A			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	781					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						CTTCTCTAGCCCAAAATCGTG	0.318000													18	74					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616152	248616152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248616152C>T	ENST00000342927.3	+	1	76	c.54C>T	c.(52-54)ctC>ctT	p.L18L		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCACAGGCCTCATCACCCATC	0.517000													38	173					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14378223	14378223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:14378223C>T	ENST00000403951.2	-	23	2461	c.2042G>A	c.(2041-2043)cGa>cAa	p.R681Q	DGKB_ENST00000444700.2_Missense_Mutation_p.R662Q|DGKB_ENST00000402815.1_Missense_Mutation_p.R680Q|DGKB_ENST00000406247.3_Missense_Mutation_p.R681Q|DGKB_ENST00000399322.3_Missense_Mutation_p.R681Q|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Missense_Mutation_p.R681Q|DGKB_ENST00000407950.1_Missense_Mutation_p.R673Q			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	681					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding	p.R681Q(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TCGATGGCTTCGTCTTTTCTT	0.398000													36	81					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120989131	120989131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120989131G>A	ENST00000392793.1	+	7	1178	c.907G>A	c.(907-909)Gag>Aag	p.E303K	TECTA_ENST00000264037.2_Missense_Mutation_p.E303K			O75443	TECTA_HUMAN	tectorin alpha	303	VWFC.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix		p.E303K(1)	TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TAGCCCCTACGAGGTGTGCGA	0.537000													27	67					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2705044	2705044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2705044C>T	ENST00000399655.1	+	20	2933	c.2668C>T	c.(2668-2670)Cgc>Tgc	p.R890C	CACNA1C_ENST00000347598.4_Missense_Mutation_p.R890C|CACNA1C_ENST00000399591.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000480911.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000344100.3_Missense_Mutation_p.R890C|CACNA1C_ENST00000399597.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000335762.5_Missense_Mutation_p.R915C|CACNA1C_ENST00000399595.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399603.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399617.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399606.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399621.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399601.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399638.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399649.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399644.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399629.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000327702.7_Missense_Mutation_p.R890C|CACNA1C_ENST00000399634.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399637.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000406454.3_Missense_Mutation_p.R890C|CACNA1C_ENST00000402845.3_Missense_Mutation_p.R890C|CACNA1C_ENST00000399641.1_Missense_Mutation_p.R890C	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	890					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GTACAGGTTTCGCCTCCAGTG	0.582000													34	80					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227983423	227983423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227983423C>T	ENST00000396625.3	-	7	634	c.427G>A	c.(427-429)Ggc>Agc	p.G143S	COL4A4_ENST00000329662.7_Missense_Mutation_p.G143S	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	143	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTCTTGAGCCATTGTGGCCA	0.502000													27	78					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6228308	6228308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6228308C>T	ENST00000262450.3	-	2	208	c.109G>A	c.(109-111)Gat>Aat	p.D37N	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	37					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AAAAAGTCATCGAAGGCTTCA	0.493000													77	198					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501994	140501994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140501994C>T	ENST00000194152.1	+	1	414	c.414C>T	c.(412-414)ctC>ctT	p.L138L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		138	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGAAGTGCTCTTGAAAATAC	0.408000													30	86					0	0	1	0	0
P2RY6	5031	broad.mit.edu	37	11	73007962	73007962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73007962C>T	ENST00000393590.2	+	2	698	c.399C>T	c.(397-399)gcC>gcT	p.A133A	P2RY6_ENST00000393591.1_Silent_p.A133A|P2RY6_ENST00000542092.1_Silent_p.A133A|P2RY6_ENST00000540342.1_Silent_p.A133A|P2RY6_ENST00000540124.1_Silent_p.A133A|P2RY6_ENST00000538328.1_Silent_p.A133A|P2RY6_ENST00000393592.2_Silent_p.A133A|P2RY6_ENST00000349767.2_Silent_p.A133A	NM_001277207.1|NM_001277208.1	NP_001264136.1|NP_001264137.1	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y, G-protein coupled, 6	133					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)	14						ACCCGCTGGCCCCCTGGCACA	0.657000													8	88					0	0	1	0	0
GCNT3	9245	broad.mit.edu	37	15	59910953	59910953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:59910953C>T	ENST00000396065.1	+	3	964	c.516C>T	c.(514-516)ttC>ttT	p.F172F	GCNT3_ENST00000560585.1_Silent_p.F172F	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	172					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CAGAAACTTTCAAAGAGGCGG	0.463000													27	121					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41145444	41145444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41145444G>A	ENST00000344051.4	+	3	832	c.598G>A	c.(598-600)Gta>Ata	p.V200I	SPINT1_ENST00000431806.1_Missense_Mutation_p.V200I|SPINT1_ENST00000562057.1_Missense_Mutation_p.V200I			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	200						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GGATGTCAGGGTAGAGGTGAG	0.612000													22	67					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143959	56143959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56143959C>T	ENST00000302270.1	+	1	860	c.860C>T	c.(859-861)cCc>cTc	p.P287L		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					ATGTTGAATCCCTTAATCTAT	0.373000													17	214					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861758	52861758	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52861758C>G	ENST00000343457.3	-	4	1436	c.1430G>C	c.(1429-1431)aGg>aCg	p.R477T		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	477						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						CTTTCTGCTCCTTCCCAGAGT	0.542000													27	89					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75051446	75051446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75051446C>T	ENST00000310715.3	-	19	2302	c.2182G>A	c.(2182-2184)Gat>Aat	p.D728N	TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000355577.3_Missense_Mutation_p.D197N|TTC18_ENST00000401621.2_Missense_Mutation_p.D728N|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000394865.1_Missense_Mutation_p.D728N	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	728							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CAAGTAGCATCCTCAAAGAAA	0.393000													12	27					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32272248	32272248	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32272248C>T	ENST00000400246.1	+	37	3944	c.3802C>T	c.(3802-3804)Cga>Tga	p.R1268*	DEPDC5_ENST00000382111.2_Nonsense_Mutation_p.R1268*|DEPDC5_ENST00000400248.1_Nonsense_Mutation_p.R1237*|DEPDC5_ENST00000400249.2_Nonsense_Mutation_p.R1237*|DEPDC5_ENST00000382105.2_Intron|DEPDC5_ENST00000535622.1_Nonsense_Mutation_p.R1168*|DEPDC5_ENST00000539165.1_Nonsense_Mutation_p.R85*|DEPDC5_ENST00000266091.3_Nonsense_Mutation_p.R1246*|DEPDC5_ENST00000382112.3_Nonsense_Mutation_p.R1259*			O75140	DEPD5_HUMAN	DEP domain containing 5	1237					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						AGAGCCCGACCGAGGTTAGAG	0.532000													45	90					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848171	123848171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123848171C>T	ENST00000531945.1	-	1	317	c.228G>A	c.(226-228)ctG>ctA	p.L76L		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AGAGGTGCCCCAGGAAGTGGT	0.547000													12	36					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31341692	31341692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31341692G>A	ENST00000544665.3	+	27	3198	c.3127G>A	c.(3127-3129)Gaa>Aaa	p.E1043K	ITGAM_ENST00000287497.8_Missense_Mutation_p.E1042K	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1042					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CATCCAGGAAGAATTCAATGC	0.582000													27	69					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220472776	220472776	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220472776C>T	ENST00000456909.1	+	14	1317	c.1227C>T	c.(1225-1227)ttC>ttT	p.F409F	STK11IP_ENST00000295641.10_Silent_p.F420F			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	420					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGGATGGTTCGTGCAGCAGC	0.627000													24	30					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115412772	115412772	+	Silent	SNP	G	G	A	rs149492667		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115412772G>A	ENST00000369358.4	-	6	736	c.492C>T	c.(490-492)ccC>ccT	p.P164P	NRAP_ENST00000360478.3_Silent_p.P164P|NRAP_ENST00000359988.3_Silent_p.P164P|NRAP_ENST00000369360.3_Silent_p.P164P			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	164						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CCTTGCCCCTGGGTTGCTCAT	0.473000													35	96					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51446170	51446170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51446170G>A	ENST00000298355.3	-	9	3126	c.2005C>T	c.(2005-2007)Ccc>Tcc	p.P669S	TRIM9_ENST00000338969.5_Missense_Mutation_p.P750S	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	669	B30.2/SPRY.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					AATGCTATGGGACCTTGTTGT	0.488000													78	166					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332700	70332700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70332700C>T	ENST00000338508.4	-	32	3700	c.3701G>A	c.(3700-3702)gGa>gAa	p.G1234E	SHANK2_ENST00000423696.2_Missense_Mutation_p.G854E|SHANK2_ENST00000409161.1_Missense_Mutation_p.G637E|SHANK2_ENST00000449833.2_Missense_Mutation_p.G638E			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	854					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCCTTTGGGTCCCTGTTGAGA	0.607000													50	79					0	0	1	0	0
GIN1	54826	broad.mit.edu	37	5	102440250	102440250	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:102440250G>A	ENST00000399004.2	-	4	728	c.634C>T	c.(634-636)Caa>Taa	p.Q212*	GIN1_ENST00000508629.1_Nonsense_Mutation_p.Q212*|GIN1_ENST00000511400.1_5'UTR	NM_017676.2	NP_060146.2	Q9NXP7	GIN1_HUMAN	gypsy retrotransposon integrase 1	212	Integrase catalytic.				DNA integration		DNA binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		CTTACCTGTTGAATGAATTCA	0.343000													8	21					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155450803	155450803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155450803C>T	ENST00000461783.3	+	6	1719	c.446C>T	c.(445-447)tCc>tTc	p.S149F	TIAM2_ENST00000318981.5_Missense_Mutation_p.S149F|TIAM2_ENST00000367174.2_5'UTR|TIAM2_ENST00000529824.2_Missense_Mutation_p.S149F|TIAM2_ENST00000360366.4_Missense_Mutation_p.S149F|TIAM2_ENST00000456144.1_Missense_Mutation_p.S149F			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	149					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGCATTGCCTCCACCCCACCG	0.572000													15	25					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148112648	148112648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148112648G>A	ENST00000361727.3	+	24	4452	c.3936G>A	c.(3934-3936)atG>atA	p.M1312I	CNTNAP2_ENST00000538075.1_Missense_Mutation_p.M371I|CNTNAP2_ENST00000463592.2_3'UTR	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1312					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCGCCATCATGAACAACGACC	0.542000										HNSCC(39;0.1)			14	81					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24669876	24669876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24669876G>A	ENST00000376454.3	+	3	463	c.433G>A	c.(433-435)Gct>Act	p.A145T	KIAA1217_ENST00000376452.3_Missense_Mutation_p.A145T|KIAA1217_ENST00000458595.1_Missense_Mutation_p.A145T|KIAA1217_ENST00000376462.1_Missense_Mutation_p.A65T|KIAA1217_ENST00000430453.2_Missense_Mutation_p.A66T	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	145			A -> G (in dbSNP:rs17506606).		embryonic skeletal system development	cytoplasm		p.A145T(1)		breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AGAGACGTCCGCTGATTCTTT	0.542000													21	80					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960273	73960273	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73960273T>A	ENST00000373468.1	-	3	4770	c.4119A>T	c.(4117-4119)acA>acT	p.T1373T	KIAA2022_ENST00000055682.5_Silent_p.T1373T			Q5QGS0	K2022_HUMAN	KIAA2022	1373					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						ACTCCTGTGGTGTCCCAGCCA	0.458000													43	29					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69935090	69935090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:69935090G>A	ENST00000358913.5	+	12	3063	c.2575G>A	c.(2575-2577)Gga>Aga	p.G859R	MYPN_ENST00000354393.2_Missense_Mutation_p.G584R|MYPN_ENST00000540630.1_Missense_Mutation_p.G859R	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	859						nucleus|sarcomere	actin binding	p.G859R(1)		breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GCCATCCCAGGGATTAGCGAA	0.423000													21	35					0	0	1	0	0
HAL	3034	broad.mit.edu	37	12	96389457	96389457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:96389457C>T	ENST00000261208.3	-	2	600	c.232G>A	c.(232-234)Gag>Aag	p.E78K	HAL_ENST00000538703.1_Missense_Mutation_p.E78K|HAL_ENST00000541929.1_5'UTR	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	78					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	TCCACGAACTCGTTGTTCTCT	0.627000													7	66					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50827018	50827018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50827018G>A	ENST00000376959.2	-	2	1355	c.1192C>T	c.(1192-1194)Ctc>Ttc	p.L398F	KCNC3_ENST00000391818.2_Intron|KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000477616.1_Missense_Mutation_p.L398F			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	398					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		AGGCCCGAGAGGCCCACCTCG	0.597000													25	37					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16385458	16385458	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:16385458C>T	ENST00000354981.2	-	17	1941	c.1784_splice	c.e17+1	p.G595_splice	KIF16B_ENST00000408042.1_Splice_Site_p.G595_splice|KIF16B_ENST00000355755.3_Splice_Site_p.G595_splice|KIF16B_ENST00000378003.2_5'UTR	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	595					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						GTTCACTCACCCGGGGTTATA	0.478000													10	29					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100774643	100774643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100774643C>T	ENST00000323346.5	+	2	579	c.266C>T	c.(265-267)tCc>tTc	p.S89F	SLC17A8_ENST00000392989.3_Missense_Mutation_p.S89F	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	89					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TTCTGCATTTCCTTTGGGATC	0.517000													28	127					0	0	1	0	0
RPUSD3	285367	broad.mit.edu	37	3	9882454	9882454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9882454G>A	ENST00000383820.5	-	5	444	c.443C>T	c.(442-444)cCc>cTc	p.P148L	RPUSD3_ENST00000433535.2_Missense_Mutation_p.P133L|RPUSD3_ENST00000424438.1_Missense_Mutation_p.P116L|TTLL3_ENST00000455274.1_Intron	NM_173659.3	NP_775930.2	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	148					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(2)|endometrium(3)|lung(2)	7	Medulloblastoma(99;0.227)					AGCTGTCTGGGGACAGCTGGA	0.527000													8	30					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45005740	45005740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:45005740G>A	ENST00000258787.7	-	16	2225	c.2089C>T	c.(2089-2091)Cgg>Tgg	p.R697W		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	697						myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						ACCAGTGTCCGGGGTGAGCGG	0.642000													10	37					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	633625	633625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:633625C>T	ENST00000026218.5	+	10	2362	c.2274C>T	c.(2272-2274)gtC>gtT	p.V758V	PIGQ_ENST00000321878.5_3'UTR	NM_148920.2	NP_683721.1	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	758					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				CTGGAGAGGTCGCTTTGTGAA	0.647000													24	52					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13882840	13882840	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13882840G>A	ENST00000265104.4	-	21	3363	c.3259C>T	c.(3259-3261)Caa>Taa	p.Q1087*	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1087	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CATTTACCTTGAAGTTCATTT	0.303000									Kartagener syndrome				6	46					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62536530	62536530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:62536530G>A	ENST00000430451.2	+	2	930	c.733G>A	c.(733-735)Gaa>Aaa	p.E245K	SYT16_ENST00000446982.2_Missense_Mutation_p.E245K|RP11-355I22.5_ENST00000553990.1_lincRNA	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	245										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		ATCTGCCTGCGAAGGTATCCT	0.483000													12	48					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121008491	121008491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121008491C>T	ENST00000392793.1	+	11	3574	c.3303C>T	c.(3301-3303)atC>atT	p.I1101I	TECTA_ENST00000264037.2_Silent_p.I1101I			O75443	TECTA_HUMAN	tectorin alpha	1101	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCTCCTGCATCGTCTCAGGCT	0.587000													20	30					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52256720	52256720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52256720C>T	ENST00000597542.1	-	9	2641	c.1684G>A	c.(1684-1686)Gag>Aag	p.E562K	TLR9_ENST00000360658.2_Missense_Mutation_p.E538K|TLR9_ENST00000494383.1_Missense_Mutation_p.R691Q			Q9NR96	TLR9_HUMAN	toll-like receptor 9	538					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	AATGAGTGCTCGTGGTAGAGG	0.602000													12	42					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10525053	10525053	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10525053G>A	ENST00000396560.2	+	3	803	c.576G>A	c.(574-576)aaG>aaA	p.K192K	ATF7IP2_ENST00000396559.1_Silent_p.K192K|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000356427.2_Silent_p.K192K|ATF7IP2_ENST00000324570.5_Silent_p.K192K	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						TGGGTGACAAGAAAACTGACC	0.423000													10	102					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45132974	45132974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45132974G>A	ENST00000296129.1	-	7	1818	c.1684C>T	c.(1684-1686)Ccc>Tcc	p.P562S		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	562						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCCCAGTTGGGGGTCCTCAGG	0.572000													6	15					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43400228	43400228	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43400228C>T	ENST00000244533.3	+	1	740	c.381C>T	c.(379-381)gcC>gcT	p.A127A	ABCC10_ENST00000443426.2_Intron|ABCC10_ENST00000372530.4_Silent_p.A170A	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	170						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCCATGGCCCGCCTATGCT	0.652000													42	80					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41585482	41585482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41585482C>T	ENST00000396942.1	-	4	354	c.271G>A	c.(271-273)Gat>Aat	p.D91N	ANK1_ENST00000289734.7_Missense_Mutation_p.D91N|ANK1_ENST00000347528.4_Missense_Mutation_p.D91N|ANK1_ENST00000379758.2_Missense_Mutation_p.D91N|ANK1_ENST00000352337.4_Missense_Mutation_p.D91N|ANK1_ENST00000265709.8_Missense_Mutation_p.D124N|ANK1_ENST00000396945.1_Missense_Mutation_p.D91N			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	91	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACCACCTCATCCTGCCCGGCT	0.602000													13	65					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142626169	142626169	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142626169G>A	ENST00000265310.1	-	5	882	c.534C>T	c.(532-534)atC>atT	p.I178I	TRPV5_ENST00000442623.1_Silent_p.I178I	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	178					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCAGCCGCACGATCTCCTCGC	0.617000													10	31					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85863064	85863064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:85863064C>T	ENST00000304195.3	-	14	1769	c.1563G>A	c.(1561-1563)gtG>gtA	p.V521V	FRMD3_ENST00000376438.1_Silent_p.V521V|FRMD3_ENST00000465485.1_5'UTR|FRMD3_ENST00000376434.1_Silent_p.V327V|FRMD3_ENST00000328788.1_Silent_p.V178V	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	521						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						CCAGTGGGTTCACCCGAATAT	0.517000													26	58					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45361850	45361850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45361850G>A	ENST00000559488.1	+	4	419	c.403G>A	c.(403-405)Gat>Aat	p.D135N	ITGB3_ENST00000571680.1_Missense_Mutation_p.D135N|ITGB3_ENST00000560629.1_Missense_Mutation_p.G123E|ITGB3_ENST00000435993.2_Missense_Mutation_p.D88N	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	135	VWFA.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	GCAGGTGGAGGATTACCCTGT	0.468000													16	37					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27455991	27455991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27455991G>A	ENST00000337929.3	+	6	1109	c.636G>A	c.(634-636)ggG>ggA	p.G212G	IL21R_ENST00000564089.1_Silent_p.G212G|IL21R_ENST00000564583.1_3'UTR|IL21R_ENST00000395755.1_Silent_p.G212G|IL21R_ENST00000395754.4_Silent_p.G212G	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	212					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						CCTACCAGGGGACCTGGAGTG	0.582000			T	BCL6	NHL								19	86					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814171	60814171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60814171G>A	ENST00000544856.2	-	7	1433	c.1055C>T	c.(1054-1056)tCa>tTa	p.S352L	MARCH10_ENST00000583600.1_Missense_Mutation_p.S391L|RP11-156L14.1_ENST00000577270.1_RNA|RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.S353L|MARCH10_ENST00000311269.5_Missense_Mutation_p.S353L			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	353							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						TATTCTCAATGAGCCATGACT	0.493000													50	108					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38445684	38445684	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38445684G>A	ENST00000397210.3	+	0	43				EGFLAM_ENST00000336740.6_Intron|EGFLAM_ENST00000506135.1_De_novo_Start_InFrame|EGFLAM_ENST00000322350.5_Intron|EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000354891.3_Intron	NM_182801.2	NP_877953.1	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains							cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GAGAAACAAGGCTGGCTTCAA	0.522000													22	57					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046780	73046780	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73046780C>T	ENST00000604411.1	+	0	34741				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CCAACTCAGGCCTTCGGTCCA	0.493000													27	23					0	0	1	0	0
RPRD1B	58490	broad.mit.edu	37	20	36676878	36676878	+	Missense_Mutation	SNP	C	C	T	rs140300358		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36676878C>T	ENST00000373433.4	+	3	812	c.410C>T	c.(409-411)cCc>cTc	p.P137L		NM_021215.3	NP_067038.1	Q9NQG5	RPR1B_HUMAN	regulation of nuclear pre-mRNA domain containing 1B	137										endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)	12						AGCCCTCCCCCCAAAGGTAGA	0.478000													16	64					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7846791	7846791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7846791G>A	ENST00000328375.1	-	1	728	c.729C>T	c.(727-729)tcC>tcT	p.S243S	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAGTGAGGTGGGAGGTGCAGG	0.507000													23	88					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323636	79323636	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79323636A>T	ENST00000428286.1	-	8	3677	c.2477T>A	c.(2476-2478)gTa>gAa	p.V826E	PRUNE2_ENST00000376718.3_Missense_Mutation_p.V1185E			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1185					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CTCCCAATCTACCTGATTTGC	0.498000													19	68					0	0	1	0	0
TRBV2	28620	broad.mit.edu	37	7	142001208	142001208	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142001208C>T	ENST00000455382.2	+	0	374																											AGATCCGGTCCACAAAGCTGG	0.453000													6	26					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120996131	120996131	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120996131C>T	ENST00000392793.1	+	8	1595	c.1324C>T	c.(1324-1326)Cag>Tag	p.Q442*	TECTA_ENST00000264037.2_Nonsense_Mutation_p.Q442*			O75443	TECTA_HUMAN	tectorin alpha	442	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TTTTGATGGCCAGCACTACGC	0.483000													91	390					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17657537	17657537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17657537C>T	ENST00000375448.4	+	2	192	c.166C>T	c.(166-168)Cct>Tct	p.P56S	PADI4_ENST00000375453.1_Missense_Mutation_p.P56S|AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	56					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	TGCCCACGGCCCTCCAGCCAA	0.602000													23	44					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127505	152127505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152127505C>T	ENST00000316073.3	-	3	2134	c.2070G>A	c.(2068-2070)caG>caA	p.Q690Q		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	690	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TGGTCTGGGCCTGTCTGTGGC	0.527000													61	160					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389325	1389325	+	Silent	SNP	C	C	T	rs71299249		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1389325C>T	ENST00000324803.4	+	1	3986	c.1026C>T	c.(1024-1026)gcC>gcT	p.A342A		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	342					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GAGTGCCCGCCTGCTCACACG	0.667000													31	345					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20344970	20344970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20344970C>T	ENST00000298642.2	+	1	580	c.544C>T	c.(544-546)Cct>Tct	p.P182S		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGTGACCTTCCTGTGGTGTT	0.423000													134	315					0	0	1	0	0
TDP2	51567	broad.mit.edu	37	6	24667042	24667042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24667042C>T	ENST00000378198.4	-	1	219	c.49G>A	c.(49-51)Gag>Aag	p.E17K	TDP2_ENST00000545995.1_Missense_Mutation_p.E47K			O95551	TYDP2_HUMAN	tyrosyl-DNA phosphodiesterase 2	17					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			kidney(2)|large_intestine(1)|lung(5)|ovary(1)	9						GGCTCGCCCTCTTCCTCCGCC	0.647000								Direct reversal of damage					106	242					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144874791	144874791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:144874791G>A	ENST00000369359.4	-	33	5263	c.5225C>T	c.(5224-5226)tCt>tTt	p.S1742F	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S1606F|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S1562F|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S1742F|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S1606F|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1606			A -> S (in dbSNP:rs1698605).		cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTGCTGGGAGAGCGGTGGGA	0.547000			T	PDGFRB	MPD								29	328					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045324	142045324	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142045324G>A	ENST00000390392.3	+	0	73																											TCACCCAGAGGACCCCAGTCA	0.602000													20	84					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33559689	33559689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:33559689G>A	ENST00000265371.4	-	4	869	c.344C>T	c.(343-345)tCa>tTa	p.S115L	NRP1_ENST00000395995.1_Missense_Mutation_p.S115L|NRP1_ENST00000374867.2_Missense_Mutation_p.S115L|NRP1_ENST00000374816.3_Missense_Mutation_p.S115L|NRP1_ENST00000374822.4_Missense_Mutation_p.S115L|NRP1_ENST00000374821.5_Missense_Mutation_p.S115L|NRP1_ENST00000374823.5_Missense_Mutation_p.S115L			O14786	NRP1_HUMAN	neuropilin 1	115	CUB 1.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	AAATGGCCCTGAAGACACAAC	0.403000													24	64					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	51943380	51943380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:51943380G>A	ENST00000311234.4	-	16	2643	c.2171C>T	c.(2170-2172)tCa>tTa	p.S724L	INTS6_ENST00000463928.1_3'UTR|INTS6_ENST00000497989.1_Missense_Mutation_p.S546L|INTS6_ENST00000398119.2_Missense_Mutation_p.S711L|INTS6_ENST00000425000.1_Missense_Mutation_p.S292L|INTS6_ENST00000490542.1_Missense_Mutation_p.S408L	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	724					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity	p.S724L(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		AATGTCTGATGAAAGTTGGTC	0.388000													9	64					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85981972	85981972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85981972C>T	ENST00000372113.4	-	3	1362	c.1357G>A	c.(1357-1359)Gat>Aat	p.D453N	LRIT2_ENST00000538192.1_Missense_Mutation_p.D463N	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	453						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						CCACCAGCATCTCTGCCTGTT	0.597000													35	94					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73485203	73485203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73485203G>A	ENST00000224721.6	+	29	3525	c.3520G>A	c.(3520-3522)Gag>Aag	p.E1174K	C10orf105_ENST00000398786.2_Intron	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1169	Cadherin 11.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CCTGGACCGGGAGCGGAACTC	0.657000													10	32					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103249038	103249038	+	Silent	SNP	C	C	T	rs62508587		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:103249038C>T	ENST00000553106.1	-	6	1054	c.582G>A	c.(580-582)ctG>ctA	p.L194L	PAH_ENST00000307000.2_Silent_p.L189L	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	194			L -> P (in PKU).|Missing (in PKU).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	ACAAGGACTTCAGAGTCTTGA	0.438000													12	57					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47571890	47571890	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47571890C>T	ENST00000334194.3	+	9	1161	c.1158C>T	c.(1156-1158)ctC>ctT	p.L386L	CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	386						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						CCCGGTTACTCGACAAACCCA	0.463000													10	126					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117996324	117996324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117996324G>A	ENST00000425217.1	-	8	1347	c.1293C>T	c.(1291-1293)atC>atT	p.I431I	KSR2_ENST00000302438.5_Silent_p.I157I|KSR2_ENST00000339824.5_Silent_p.I460I|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	460					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCGGTGGATGATCAGAAGAT	0.507000													9	61					0	0	1	0	0
CCM2	83605	broad.mit.edu	37	7	45108060	45108060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:45108060C>T	ENST00000381112.3	+	5	1233	c.554C>T	c.(553-555)tCc>tTc	p.S185F	CCM2_ENST00000541586.1_Missense_Mutation_p.S106F|CCM2_ENST00000258781.6_Missense_Mutation_p.S164F|CCM2_ENST00000475551.1_Missense_Mutation_p.S158F|CCM2_ENST00000544363.1_Intron|CCM2_ENST00000474617.1_Intron|CCM2_ENST00000461377.1_3'UTR	NM_001029835.2	NP_001025006.1	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2	164	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding			NS(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						CCAGGGATCTCCCCCAGCCAG	0.612000													33	63					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61988009	61988009	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:61988009C>T	ENST00000409186.1	-	5	2328	c.223G>A	c.(223-225)Gga>Aga	p.G75R	PCDH20_ENST00000409204.4_Missense_Mutation_p.G75R			Q8N6Y1	PCD20_HUMAN	protocadherin 20	48	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GCGGGTAGTCCCTCGTTTAGG	0.652000													4	20					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68747555	68747555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68747555G>A	ENST00000309106.3	-	1	900	c.901C>T	c.(901-903)Cgc>Tgc	p.R301C		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	301						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGCTCCTCGCGAAGCGCCTGT	0.677000													35	65					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113496541	113496541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113496541G>A	ENST00000416899.2	+	6	765	c.639G>A	c.(637-639)agG>agA	p.R213R	MUSK_ENST00000374448.4_Silent_p.R213R|MUSK_ENST00000189978.5_Silent_p.R213R			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	213	Ig-like 3.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						TTTTTGCCAGGATCCTGCGGG	0.502000													5	21					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9983625	9983625	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:9983625T>C	ENST00000256190.8	-	16	1876	c.1739A>G	c.(1738-1740)aAa>aGa	p.K580R		NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	580					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TGCCTTTCCTTTAAGGGCTCT	0.448000													28	62					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36623931	36623931	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:36623931G>A	ENST00000280527.2	+	2	872		c.e2+1			NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)						nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				AGAATTGAAGGTAAGCATTAA	0.373000													22	96					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153149829	153149829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153149829G>A	ENST00000285900.5	+	13	2467	c.2124G>A	c.(2122-2124)agG>agA	p.R708R	GRIA1_ENST00000518142.1_Silent_p.R628R|GRIA1_ENST00000518783.1_Silent_p.R718R|GRIA1_ENST00000521843.2_Silent_p.R639R|GRIA1_ENST00000448073.4_Silent_p.R718R|GRIA1_ENST00000340592.5_Silent_p.R708R	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	708					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTCGAGTGAGGAAATCCAAAG	0.483000													22	59					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475030	16475030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16475030G>A	ENST00000358432.5	-	3	820	c.666C>T	c.(664-666)tcC>tcT	p.S222S	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	222	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CAGTGGCCAGGGAAGGTGCAT	0.662000													7	55					0	0	1	0	0
USP49	25862	broad.mit.edu	37	6	41774051	41774051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41774051G>A	ENST00000394253.3	-	3	1000	c.671C>T	c.(670-672)tCg>tTg	p.S224L	USP49_ENST00000373010.1_Missense_Mutation_p.S224L|USP49_ENST00000373006.1_Missense_Mutation_p.S224L|USP49_ENST00000373009.3_Missense_Mutation_p.S224L|USP49_ENST00000297229.2_Missense_Mutation_p.S224L			Q70CQ1	UBP49_HUMAN	ubiquitin specific peptidase 49	224					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(2)|skin(2)	23	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ggcggggcgcgaggcagccgg	0.751000													16	16					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12203184	12203184	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12203184C>T	ENST00000432424.2	+	0	1009							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TTGTGAACTGCTATTCTCCCT	0.507000													9	14					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157669500	157669500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157669500G>A	ENST00000368184.3	-	3	325	c.34C>T	c.(34-36)Cct>Tct	p.P12S	FCRL3_ENST00000368186.5_Missense_Mutation_p.P12S	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	12						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					TCTCTTCCAGGAGCTGTGAGG	0.468000													11	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179501469	179501469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179501469C>T	ENST00000589042.1	-	225	41209	c.40985G>A	c.(40984-40986)gGa>gAa	p.G13662E	TTN_ENST00000342992.6_Missense_Mutation_p.G11094E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G12021E|TTN_ENST00000342175.6_Missense_Mutation_p.G4789E|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000418062.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G4722E|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G4597E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12021	Ig-like 93.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCACCACTTCCTGGCCTTAA	0.423000													24	57					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153056708	153056708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153056708G>A	ENST00000285900.5	+	7	1359	c.1016G>A	c.(1015-1017)aGa>aAa	p.R339K	GRIA1_ENST00000518142.1_Missense_Mutation_p.R259K|GRIA1_ENST00000518783.1_Missense_Mutation_p.R349K|GRIA1_ENST00000521843.2_Missense_Mutation_p.R270K|GRIA1_ENST00000448073.4_Missense_Mutation_p.R349K|GRIA1_ENST00000340592.5_Missense_Mutation_p.R339K	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	339					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GACATCCAGAGAGCTCTGCAG	0.517000													10	36					0	0	1	0	0
CUEDC1	404093	broad.mit.edu	37	17	55962752	55962752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:55962752G>A	ENST00000577830.1	-	2	587	c.174C>T	c.(172-174)ttC>ttT	p.F58F	CUEDC1_ENST00000360238.2_Silent_p.F58F|CUEDC1_ENST00000407144.2_Silent_p.F58F|CUEDC1_ENST00000577840.1_Intron	NM_001271875.1	NP_001258804.1	Q9NWM3	CUED1_HUMAN	CUE domain containing 1	58	CUE.									endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12						CCATGTTGGGGAACATGGTCT	0.647000													33	55					0	0	1	0	0
KLRC3	3823	broad.mit.edu	37	12	10569274	10569274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10569274G>A	ENST00000396439.2	-	5	623	c.579C>T	c.(577-579)ttC>ttT	p.F193F	KLRC3_ENST00000381903.2_Silent_p.F193F|KLRC3_ENST00000381904.2_Silent_p.F193F|NKG2-E_ENST00000539033.1_Silent_p.F193F	NM_002261.2	NP_002252.2			killer cell lectin-like receptor subfamily C, member 3											large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						ACTCATGTTTGAAAGCCAAAC	0.318000													16	77					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043528	56043528	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56043528C>T	ENST00000313033.2	+	1	500	c.414C>T	c.(412-414)atC>atT	p.I138I		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					ATGTAGCCATCTACAACCCTC	0.428000													97	184					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92734558	92734558	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92734558G>A	ENST00000379958.2	-	3	1122	c.853C>T	c.(853-855)Cga>Tga	p.R285*		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	285						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTGGCTCTCGAATGCACTTC	0.373000													36	92					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103400012	103400012	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103400012C>A	ENST00000358392.2	-	46	3946	c.3629G>T	c.(3628-3630)gGt>gTt	p.G1210V	COL11A1_ENST00000512756.1_Missense_Mutation_p.G1082V|COL11A1_ENST00000353414.4_Missense_Mutation_p.G1159V|COL11A1_ENST00000370096.3_Missense_Mutation_p.G1198V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1198	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TACCTGAAGACCTATTGGACC	0.458000													15	70					4.14922e-12	4.16807e-12	1	1	0
PCLO	27445	broad.mit.edu	37	7	82545094	82545094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82545094C>T	ENST00000423517.2	-	7	12545	c.12208G>A	c.(12208-12210)Gaa>Aaa	p.E4070K	PCLO_ENST00000437081.1_Missense_Mutation_p.E790K|PCLO_ENST00000333891.8_Missense_Mutation_p.E4070K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4001					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGATCCTTTTCATGAAGGCTA	0.448000													3	17					0	0	1	0	0
SKAP2	8935	broad.mit.edu	37	7	26778453	26778453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:26778453G>A	ENST00000345317.2	-	6	743	c.430C>T	c.(430-432)Ctc>Ttc	p.L144F	SKAP2_ENST00000539623.1_5'UTR|SKAP2_ENST00000489977.1_5'UTR	NM_003930.3	NP_003921.2	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	144	PH.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						GTTTTACTGAGAGCACACCAC	0.363000													42	75					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237037098	237037098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237037098C>T	ENST00000366577.5	+	23	2825	c.2431C>T	c.(2431-2433)Cca>Tca	p.P811S	MTR_ENST00000535889.1_Missense_Mutation_p.P760S	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	811	B12-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGTCATGACTCCATGTGATAA	0.378000													27	85					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96962966	96962966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:96962966C>T	ENST00000389672.5	+	5	1479	c.1441C>T	c.(1441-1443)Cgc>Tgc	p.R481C	EPHA6_ENST00000470610.2_Missense_Mutation_p.R481C	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	386	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TGGAGGACTCCGCTTCATCCC	0.448000													19	46					0	0	1	0	0
CIB2	10518	broad.mit.edu	37	15	78401619	78401619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78401619C>T	ENST00000258930.3	-	4	632	c.304G>A	c.(304-306)Gct>Act	p.A102T	CIB2_ENST00000539011.1_Missense_Mutation_p.A59T|CIB2_ENST00000560618.1_Missense_Mutation_p.A59T|CIB2_ENST00000557846.1_Missense_Mutation_p.A53T	NM_006383.2	NP_006374.1	O75838	CIB2_HUMAN	calcium and integrin binding family member 2	102							calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	11						TCTCGGGGAGCCGACTCGCAG	0.552000													25	75					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38523620	38523620	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38523620G>A	ENST00000263409.4	-	5	624	c.462C>T	c.(460-462)taC>taT	p.Y154Y	LIFR_ENST00000503088.1_5'UTR|LIFR_ENST00000453190.2_Silent_p.Y154Y	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	154					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TCCACTTTAGGTATAATGTAG	0.363000			T	PLAG1	salivary adenoma								14	79					0	0	1	0	0
ZNF512	84450	broad.mit.edu	37	2	27838116	27838116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27838116C>T	ENST00000355467.4	+	11	1296	c.1213C>T	c.(1213-1215)Cgt>Tgt	p.R405C	RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000413371.2_Missense_Mutation_p.R328C|ZNF512_ENST00000556601.1_Missense_Mutation_p.R274C|ZNF512_ENST00000379717.1_Missense_Mutation_p.R404C|ZNF512_ENST00000416005.2_Missense_Mutation_p.R376C			Q96ME7	ZN512_HUMAN	zinc finger protein 512	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					GAAATATCATCGTATTCAGTG	0.373000													38	153					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101720918	101720918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101720918C>T	ENST00000261637.4	+	26	3275	c.3101C>T	c.(3100-3102)tCa>tTa	p.S1034L		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1034					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						AAATCTGCTTCAGGCACCCGC	0.463000													38	101					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86697752	86697752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86697752C>T	ENST00000441037.2	+	3	311	c.216C>T	c.(214-216)ctC>ctT	p.L72L	AGBL1_ENST00000421325.2_Silent_p.L72L	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	72					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						GCCAGAATCTCCTCCACTGTC	0.507000													20	22					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76957805	76957805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:76957805C>T	ENST00000380887.2	+	6	875	c.803C>T	c.(802-804)tCc>tTc	p.S268F	ESRRB_ENST00000509242.1_Missense_Mutation_p.S268F|ESRRB_ENST00000261532.7_Missense_Mutation_p.S268F|ESRRB_ENST00000556177.1_Missense_Mutation_p.S268F			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	268						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		TCAAGCCTCTCCCTGGGGGAC	0.647000													3	10					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89531571	89531571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:89531571C>T	ENST00000329758.1	-	8	1414	c.1086G>A	c.(1084-1086)cgG>cgA	p.R362R	TRIM49_ENST00000532501.2_Silent_p.R285R	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	362	B30.2/SPRY.					intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TCTTCTCTTTCCGATACATAT	0.453000													42	146					0	0	1	0	0
EFNB1	1947	broad.mit.edu	37	X	68060237	68060237	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:68060237C>T	ENST00000204961.4	+	5	1561	c.781C>T	c.(781-783)Cta>Tta	p.L261L		NM_004429.4	NP_004420.1	P98172	EFNB1_HUMAN	ephrin-B1	261					cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	22						CCTGACGGTCCTACTACTGAA	0.622000													12	11					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873178	55873178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55873178C>T	ENST00000313503.1	+	1	660	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					CCTATGTGTTCATTCTCTTTA	0.403000										HNSCC(53;0.14)			55	124					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188228210	188228210	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:188228210T>A	ENST00000409998.1	-	10	1301	c.520A>T	c.(520-522)Att>Ttt	p.I174F	AC007319.1_ENST00000453517.1_RNA|CALCRL_ENST00000392370.3_Missense_Mutation_p.I174F|CALCRL_ENST00000410068.1_Missense_Mutation_p.I174F|AC007319.1_ENST00000412276.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	174						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TGTAAGGTAATCCTTTGGCAA	0.353000													20	81					0	0	1	0	0
BCHE	590	broad.mit.edu	37	3	165503967	165503967	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:165503967C>T	ENST00000264381.3	-	3	1816	c.1650G>A	c.(1648-1650)tgG>tgA	p.W550*	BCHE_ENST00000540653.1_Nonsense_Mutation_p.W12*	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	550					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAAATGATGTCCAGAATCGAC	0.353000													10	67					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28848076	28848076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28848076C>T	ENST00000340394.8	+	23	3325	c.3113C>T	c.(3112-3114)cCc>cTc	p.P1038L	ATXN2L_ENST00000564304.1_Missense_Mutation_p.P1062L|ATXN2L_ENST00000395547.2_3'UTR|RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000382686.4_Silent_p.P1030P|ATXN2L_ENST00000570200.1_Missense_Mutation_p.P1056L|ATXN2L_ENST00000336783.4_3'UTR|ATXN2L_ENST00000325215.6_Silent_p.P1048P	NM_148415.2|NM_148416.2	NP_680781.1|NP_680782.1	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	1036						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						CAGCAGCTCCCCTTCCACCCC	0.582000													14	61					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186015231	186015231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186015231C>T	ENST00000265022.3	-	5	891	c.352G>A	c.(352-354)Gag>Aag	p.E118K	DGKG_ENST00000344484.4_Missense_Mutation_p.E118K|DGKG_ENST00000544847.1_Missense_Mutation_p.E118K|DGKG_ENST00000382164.4_Missense_Mutation_p.E118K	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	118					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	GCACAGGCCTCGTCTGCTTTG	0.448000													21	106					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56390337	56390337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:56390337G>A	ENST00000423270.1	-	8	1048	c.1049C>T	c.(1048-1050)tCa>tTa	p.S350L	RFX7_ENST00000317318.6_Missense_Mutation_p.S350L|RFX7_ENST00000559447.2_Missense_Mutation_p.S253L|RFX7_ENST00000422057.1_Missense_Mutation_p.S253L	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	253					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						AGAAAGGATTGAAGGATTTCC	0.423000													21	46					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42566673	42566673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42566673G>A	ENST00000262895.3	-	4	474	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S	GRIK5_ENST00000301218.4_Missense_Mutation_p.P159S|GRIK5_ENST00000593562.1_Missense_Mutation_p.P159S	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	159						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CTGGCCGAGGGGTAGTTGAAG	0.572000													33	54					0	0	1	0	0
NKG7	4818	broad.mit.edu	37	19	51875290	51875290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51875290C>T	ENST00000221978.5	-	3	522	c.343G>A	c.(343-345)Gag>Aag	p.E115K	NKG7_ENST00000600427.1_Intron|NKG7_ENST00000595217.1_Silent_p.A108A	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	115						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TCCCACCGCTCGCTGGTGTAC	0.607000													29	67					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69640520	69640520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:69640520C>T	ENST00000370598.1	+	4	1648	c.827C>T	c.(826-828)cCt>cTt	p.P276L		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	276					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				AAAAGGGTCCCTCAGGAACAA	0.343000													8	49					0	0	1	0	0
RNF38	152006	broad.mit.edu	37	9	36352839	36352839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:36352839G>A	ENST00000357058.3	-	8	1435	c.829C>T	c.(829-831)Cct>Tct	p.P277S	RNF38_ENST00000377877.4_Missense_Mutation_p.P284S|RNF38_ENST00000350199.4_Missense_Mutation_p.P277S|RNF38_ENST00000353739.4_Missense_Mutation_p.P310S|RNF38_ENST00000377885.2_Missense_Mutation_p.P277S|RNF38_ENST00000259605.6_Missense_Mutation_p.P360S	NM_194328.2	NP_919309.1	Q9H0F5	RNF38_HUMAN	ring finger protein 38	360	Pro-rich.						zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			ATAAATGGAGGATAAGGCTGC	0.403000													5	31					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103155868	103155868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103155868G>A	ENST00000424685.2	-	50	8042	c.7883C>T	c.(7882-7884)cCt>cTt	p.P2628L	RELN_ENST00000343529.5_Missense_Mutation_p.P2628L|RELN_ENST00000428762.1_Missense_Mutation_p.P2628L			P78509	RELN_HUMAN	reelin	2628					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGCATCAGGAGGGAGAAGGAT	0.478000													15	36					0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978659	10978659	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10978659G>A	ENST00000240619.2	-	1	298	c.210C>T	c.(208-210)ttC>ttT	p.F70F		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	70					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						TATTTGGAGAGAATATCTGTA	0.333000													18	44					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3831551	3831551	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3831551C>T	ENST00000309890.7	-	21	3201	c.3051G>A	c.(3049-3051)tgG>tgA	p.W1017*	ATP2A3_ENST00000352011.3_Nonsense_Mutation_p.W1017*|ATP2A3_ENST00000359983.3_Nonsense_Mutation_p.W1017*|ATP2A3_ENST00000397039.1_Intron|ATP2A3_ENST00000397041.3_Intron|ATP2A3_ENST00000397035.3_Nonsense_Mutation_p.W1017*|ATP2A3_ENST00000397043.3_Intron	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	1017					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GGTCTGGGGTCCAAGAGGTGG	0.612000													16	32					0	0	1	0	0
TSPAN12	23554	broad.mit.edu	37	7	120428761	120428761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120428761G>A	ENST00000222747.3	-	8	1410	c.803C>T	c.(802-804)tCt>tTt	p.S268F	TSPAN12_ENST00000415871.1_Missense_Mutation_p.S268F	NM_012338.3	NP_036470.1	O95859	TSN12_HUMAN	tetraspanin 12	268					angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction				endometrium(3)|kidney(1)|lung(4)|ovary(1)|skin(1)	10	all_neural(327;0.117)					CAGGTGCTGAGAGTTGTCATT	0.453000													56	112					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130932542	130932542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130932542G>A	ENST00000409031.1	-	3	1336	c.188C>T	c.(187-189)cCc>cTc	p.P63L	SMPD4_ENST00000426662.2_Intron|SMPD4_ENST00000351288.6_Missense_Mutation_p.P63L|SMPD4_ENST00000473720.1_Intron|SMPD4_ENST00000453750.1_Missense_Mutation_p.P63L|SMPD4_ENST00000431183.2_Missense_Mutation_p.P63L|SMPD4_ENST00000339679.7_5'UTR|SMPD4_ENST00000443958.2_Intron|SMPD4_ENST00000452225.2_Intron	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	24					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CTGTGCAAAGGGCTTATTTAT	0.443000													41	105					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306651	41306651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:41306651C>T	ENST00000373198.3	-	7	1243	c.1008G>A	c.(1006-1008)gaG>gaA	p.E336E	PTPRT_ENST00000373187.1_Silent_p.E336E|PTPRT_ENST00000373193.3_Silent_p.E336E|PTPRT_ENST00000373201.1_Silent_p.E336E|PTPRT_ENST00000373184.1_Silent_p.E336E|PTPRT_ENST00000356100.2_Silent_p.E336E|PTPRT_ENST00000373190.1_Silent_p.E336E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	336	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTATGTGGGTCTCTGCCCACG	0.552000													41	92					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42437980	42437980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42437980C>T	ENST00000397272.3	-	15	1753	c.1662G>A	c.(1660-1662)cgG>cgA	p.R554R	PLA2G4F_ENST00000382396.4_Silent_p.R552R	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	552	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GGTAACAGATCCGGGGTTCAG	0.632000													9	63					0	0	1	0	0
ATG16L1	55054	broad.mit.edu	37	2	234200864	234200864	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234200864C>T	ENST00000392017.4	+	15	1778	c.1521C>T	c.(1519-1521)tcC>tcT	p.S507S	ATG16L1_ENST00000392018.1_Silent_p.S524S|ATG16L1_ENST00000347464.5_Silent_p.S344S|ATG16L1_ENST00000392020.4_Silent_p.S488S|ATG16L1_ENST00000373525.5_Silent_p.S328S	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	507					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		TGAGCTGCTCCCGTGATGACT	0.473000													17	60					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902119	51902119	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:51902119C>T	ENST00000268919.4	+	1	1881	c.1725C>T	c.(1723-1725)tcC>tcT	p.S575S		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	575					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CAGAAATGTCCCTTCAGAGGG	0.403000													20	71					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53208027	53208027	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53208027C>T	ENST00000293774.4	-	1	308	c.38G>A	c.(37-39)gGg>gAg	p.G13E	KRT4_ENST00000551956.1_5'UTR			B4DRS2	B4DRS2_HUMAN	keratin 4	0						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CTTCCCGCACCCGTTGAGCAT	0.537000													22	49					0	0	1	0	0
TRGC2	6967	broad.mit.edu	37	7	38289092	38289092	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38289092C>T	ENST00000436911.2	-	0	81																											AAGGTATGTTCCAGCCTTCTG	0.403000													101	238					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102464199	102464199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102464199G>A	ENST00000260228.2	-	8	1230	c.1218C>T	c.(1216-1218)acC>acT	p.T406T		NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	406	Hemopexin-like 3.				proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CAAAGAAAAGGGTCTTCTGTG	0.388000													41	54					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102992208	102992208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102992208C>T	ENST00000375735.2	+	10	1612	c.1468C>T	c.(1468-1470)Cgc>Tgc	p.R490C	DYNC2H1_ENST00000334267.7_Missense_Mutation_p.R490C|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.R490C	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	490	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGTTTGGGTTCGCCAGTTGGA	0.368000													22	61					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42833145	42833145	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42833145C>T	ENST00000314073.5	+	13	3377	c.3201C>T	c.(3199-3201)tcC>tcT	p.S1067S	GLTSCR1L_ENST00000394168.1_Silent_p.S1067S					GLTSCR1-like																		AAACTGACTCCATTTTAGAAG	0.512000													45	115					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475910	120475910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:120475910G>A	ENST00000355622.6	+	3	1605	c.1504G>A	c.(1504-1506)Gac>Aac	p.D502N	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.D462N	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	502					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GACCTTCCTGGACCTCTCTCA	0.438000													27	54					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119731983	119731983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:119731983G>A	ENST00000541757.1	+	6	681	c.301G>A	c.(301-303)Gcc>Acc	p.A101T	MARCO_ENST00000327097.4_Missense_Mutation_p.A179T			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	179					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						TGAGAAGGGAGCCAAGGGGGC	0.562000													5	13					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23410955	23410955	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23410955C>T	ENST00000379361.4	+	3	2180	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	440					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						ATAGTATCTTCTGTAGAAAAG	0.468000													60	29					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102483436	102483436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:102483436C>T	ENST00000369138.1	+	14	2796	c.2306C>T	c.(2305-2307)cCc>cTc	p.P769L	GRIK2_ENST00000413795.1_Missense_Mutation_p.P769L|GRIK2_ENST00000369134.4_Missense_Mutation_p.P720L|GRIK2_ENST00000369137.3_Missense_Mutation_p.P693L|GRIK2_ENST00000318991.6_Missense_Mutation_p.P769L|GRIK2_ENST00000421544.1_Missense_Mutation_p.P769L	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	769					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GTTGGCACTCCCATGGGTAGG	0.438000													47	67					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48683440	48683440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48683440G>A	ENST00000416767.4	+	23	4506	c.4478G>A	c.(4477-4479)gGg>gAg	p.G1493E	CACNA1G_ENST00000514717.1_Intron|CACNA1G_ENST00000515765.1_Intron|CACNA1G_ENST00000510366.1_Intron|CACNA1G_ENST00000512389.1_Intron|CACNA1G_ENST00000513964.1_Intron|CACNA1G_ENST00000513689.2_Intron|CACNA1G_ENST00000507609.1_Intron|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000507336.1_Intron|CACNA1G_ENST00000507510.2_Intron|CACNA1G_ENST00000442258.2_Intron|CACNA1G_ENST00000514181.1_Intron|CACNA1G_ENST00000429973.2_Intron|CACNA1G_ENST00000352832.5_Intron|CACNA1G_ENST00000514079.1_Intron|CACNA1G_ENST00000515165.1_Intron|CACNA1G_ENST00000510115.1_Intron|CACNA1G_ENST00000503485.1_Intron|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000502264.1_Intron|CACNA1G_ENST00000359106.5_Intron|CACNA1G_ENST00000354983.4_Intron|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000515411.1_Intron|CACNA1G_ENST00000360761.4_Intron			O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	982					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGGGGCACAGGGCCATGCTTA	0.602000													31	49					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87179256	87179256	+	Missense_Mutation	SNP	G	G	A	rs142600685	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87179256G>A	ENST00000265724.3	-	14	1882	c.1465C>T	c.(1465-1467)Cgc>Tgc	p.R489C	ABCB1_ENST00000543898.1_Missense_Mutation_p.R425C	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	489	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CGGCCATAGCGAATGTTTTCA	0.428000													29	225					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424299	56424299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56424299G>A	ENST00000588751.1	-	5	908	c.884C>T	c.(883-885)cCc>cTc	p.P295L	NLRP13_ENST00000342929.3_Missense_Mutation_p.P295L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	295	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CTCTTCAATGGGGGCATCAAA	0.398000													26	66					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15053254	15053254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15053254C>T	ENST00000248072.3	+	1	954	c.954C>T	c.(952-954)ctC>ctT	p.L318L		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	318					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TTGCTAAGCTCTCATGAATTG	0.478000													28	52					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66479913	66479913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:66479913C>T	ENST00000256447.4	-	3	915	c.758G>A	c.(757-759)gGa>gAa	p.G253E		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	253					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		CTCAAATGTTCCCAGCCAGAG	0.438000													26	60					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51696586	51696586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51696586G>A	ENST00000335449.6	+	10	1347	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K	GLDN_ENST00000396399.2_Missense_Mutation_p.E307K	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	431	Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		AGCTGTAGATGAAAAGGGCCT	0.418000													60	153					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100657	93100657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:93100657C>T	ENST00000544406.2	+	2	516	c.250C>T	c.(250-252)Ctt>Ttt	p.L84F	C12orf74_ENST00000397833.3_Missense_Mutation_p.L84F			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	84										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						CCCATGTTACCTTTCGAAGAG	0.557000													22	48					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50058997	50058997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50058997G>A	ENST00000281631.5	+	7	597	c.439G>A	c.(439-441)Gaa>Aaa	p.E147K	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505554.1_Missense_Mutation_p.E126K|PARP8_ENST00000503750.2_Missense_Mutation_p.E147K|PARP8_ENST00000514342.2_5'UTR|PARP8_ENST00000505697.2_Missense_Mutation_p.E147K|PARP8_ENST00000514067.2_Missense_Mutation_p.E147K	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	147						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				CTATGATGGGGAACTGCACAA	0.418000													11	40					0	0	1	0	0
FAM181A	90050	broad.mit.edu	37	14	94394620	94394620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94394620G>A	ENST00000267594.5	+	3	482	c.175G>A	c.(175-177)Ggc>Agc	p.G59S	FAM181A_ENST00000557000.2_5'UTR|FAM181A_ENST00000557719.1_5'UTR|FAM181A_ENST00000556222.1_5'UTR	NM_001207073.1|NM_001207074.1|NM_138344.4	NP_001194002.1|NP_001194003.1|NP_612353.3	Q8N9Y4	F181A_HUMAN	family with sequence similarity 181, member A	59										cervix(1)|endometrium(2)|large_intestine(8)|lung(4)|prostate(1)|skin(2)	18						CTCGTGCAGTGGCCCCCTGGT	0.607000													26	56					0	0	1	0	0
EDDM3B	64184	broad.mit.edu	37	14	21238538	21238538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21238538G>A	ENST00000326783.3	+	2	327	c.229G>A	c.(229-231)Gag>Aag	p.E77K		NM_022360.4	NP_071755.1	P56851	EP3B_HUMAN	epididymal protein 3B	77					spermatid development	extracellular region				central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						GTACAAAATCGAGCATATATG	0.403000													25	71					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19350783	19350783	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:19350783C>T	ENST00000307015.9	+	20	3717	c.1965C>T	c.(1963-1965)atC>atT	p.I655I	DENND4C_ENST00000434457.2_Silent_p.I1467I|DENND4C_ENST00000602925.1_Silent_p.I1418I|DENND4C_ENST00000540671.1_Silent_p.I512I|DENND4C_ENST00000380432.2_Silent_p.I1182I			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1182						integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						ACACAAGTATCTCAGGGTTGG	0.433000													18	83					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72345521	72345521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:72345521C>T	ENST00000299687.5	+	1	2546	c.2546C>T	c.(2545-2547)tCa>tTa	p.S849L	ZNF407_ENST00000309902.6_Missense_Mutation_p.S849L|ZNF407_ENST00000582337.1_Missense_Mutation_p.S849L|ZNF407_ENST00000577538.1_Missense_Mutation_p.S849L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	849					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGTAACATCTCACGGACGTGT	0.438000													18	74					0	0	1	0	0
SCN4B	6330	broad.mit.edu	37	11	118007795	118007795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118007795C>T	ENST00000324727.4	-	5	780	c.634G>A	c.(634-636)Gag>Aag	p.E212K	SCN4B_ENST00000423160.2_5'UTR|SCN4B_ENST00000529878.1_Missense_Mutation_p.E78K	NM_001142349.1|NM_174934.3	NP_001135821.1|NP_777594.1	Q8IWT1	SCN4B_HUMAN	sodium channel, voltage-gated, type IV, beta subunit	212						voltage-gated sodium channel complex	voltage-gated sodium channel activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.33e-05)|Epithelial(105;0.00126)		AAGCCGTTCTCCGTGTTGTCA	0.577000													9	32					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450836	55450836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55450836C>T	ENST00000588756.1	-	6	1837	c.1351G>A	c.(1351-1353)Gga>Aga	p.G451R	NLRP7_ENST00000328092.5_Missense_Mutation_p.G451R|NLRP7_ENST00000340844.2_Missense_Mutation_p.G451R|NLRP7_ENST00000448121.2_Missense_Mutation_p.G451R|NLRP7_ENST00000590030.1_Missense_Mutation_p.G451R|NLRP7_ENST00000592784.1_Missense_Mutation_p.G451R|NLRP7_ENST00000446217.1_Missense_Mutation_p.G479R			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	451	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AGGATGTCTCCGTCCAGGAAC	0.622000													19	45					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622530	38622530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38622530C>T	ENST00000413689.1	-	17	3313	c.3120G>A	c.(3118-3120)ggG>ggA	p.G1040G	SCN5A_ENST00000423572.2_Silent_p.G1040G|SCN5A_ENST00000425664.1_Silent_p.G1040G|SCN5A_ENST00000333535.4_Silent_p.G1040G|SCN5A_ENST00000451551.2_Silent_p.G1040G|SCN5A_ENST00000455624.2_Silent_p.G1040G|SCN5A_ENST00000449557.2_Silent_p.G1040G|SCN5A_ENST00000450102.2_Silent_p.G1040G|SCN5A_ENST00000443581.1_Silent_p.G1040G|SCN5A_ENST00000414099.2_Silent_p.G1040G	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1040					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCTCTGGATCCCCGGGGGTGC	0.642000													3	27					0	0	1	0	0
IFIT1B	439996	broad.mit.edu	37	10	91144246	91144246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:91144246G>A	ENST00000371809.3	+	2	1256	c.1176G>A	c.(1174-1176)ggG>ggA	p.G392G	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	392							binding			endometrium(2)|large_intestine(3)|lung(8)	13						AACATCATGGGAAATCTCAAG	0.363000													28	74					0	0	1	0	0
CDX1	1044	broad.mit.edu	37	5	149546471	149546471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149546471C>T	ENST00000231656.8	+	1	114	c.32C>T	c.(31-33)tCg>tTg	p.S11L		NM_001804.2	NP_001795.2	P47902	CDX1_HUMAN	caudal type homeobox 1	11						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|lung(1)|ovary(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GACAAGGATTCGCCCGTGTAC	0.776000													4	11					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91134173	91134173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:91134173C>T	ENST00000373094.1	+	2	3779	c.2934C>T	c.(2932-2934)atC>atT	p.I978I	PCDH11X_ENST00000361655.2_Silent_p.I978I|PCDH11X_ENST00000406881.1_Silent_p.I978I|PCDH11X_ENST00000373097.1_Silent_p.I978I|PCDH11X_ENST00000361724.1_Silent_p.I978I|PCDH11X_ENST00000298274.8_Silent_p.I978I|PCDH11X_ENST00000504220.1_Silent_p.I978I|PCDH11X_ENST00000373088.1_Silent_p.I978I|PCDH11X_ENST00000395337.2_Silent_p.I978I	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	978					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GTGACTCTATCTCCAAGTGTT	0.517000													88	62					0	0	1	0	0
RTN4RL2	349667	broad.mit.edu	37	11	57235131	57235131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57235131G>A	ENST00000335099.3	+	2	398	c.81G>A	c.(79-81)gcG>gcA	p.A27A	RTN4RL2_ENST00000395120.2_Silent_p.A27A|RTN4RL2_ENST00000533205.1_Silent_p.A27A	NM_178570.1	NP_848665.1	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2	27					axon regeneration	anchored to plasma membrane	receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(2)	6						TGCCCCTGGCGGCCCCCAGCT	0.677000													26	101					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92577687	92577687	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92577687G>A	ENST00000298047.6	+	18	11171	c.11154G>A	c.(11152-11154)ctG>ctA	p.L3718L	FAT3_ENST00000525166.1_Silent_p.L3568L|FAT3_ENST00000533797.1_Silent_p.L53L|FAT3_ENST00000409404.2_Silent_p.L3718L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3718					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGCCTACCTGATCCAGAAGC	0.547000										TCGA Ovarian(4;0.039)			3	21					0	0	1	0	0
LTF	4057	broad.mit.edu	37	3	46497339	46497339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46497339C>T	ENST00000231751.4	-	4	741	c.446G>A	c.(445-447)gGg>gAg	p.G149E	LTF_ENST00000417439.1_Missense_Mutation_p.G149E|LTF_ENST00000426532.2_Missense_Mutation_p.G105E	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	149	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	ACGAAGTGTCCCTATAGGGAC	0.572000													21	37					0	0	1	0	0
DDX43	55510	broad.mit.edu	37	6	74104714	74104714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:74104714G>A	ENST00000370336.4	+	1	244	c.86G>A	c.(85-87)aGg>aAg	p.R29K	DDX43_ENST00000539829.1_Missense_Mutation_p.R29K|OOEP_ENST00000370363.1_5'UTR	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	29						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						GCGCCAGAGAGGAGGCCGGCG	0.642000													13	84					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81661830	81661830	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81661830C>T	ENST00000550584.2	-	28	3642	c.3347G>A	c.(3346-3348)tGg>tAg	p.W1116*	PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.W1116*|PPFIA2_ENST00000541570.2_Nonsense_Mutation_p.W652*|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.W1110*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.W1095*|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.W1101*|PPFIA2_ENST00000550359.2_Nonsense_Mutation_p.W963*|PPFIA2_ENST00000407050.4_Nonsense_Mutation_p.W1015*|PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.W1104*|PPFIA2_ENST00000443686.3_Nonsense_Mutation_p.W1011*|PPFIA2_ENST00000541017.1_Nonsense_Mutation_p.W302*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	1015										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TGCTTGTATCCAGCGAATAAC	0.373000													6	7					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033491	95033491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95033491C>T	ENST00000557004.1	+	3	1255	c.834C>T	c.(832-834)ttC>ttT	p.F278F	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Silent_p.F278F|SERPINA4_ENST00000298841.5_Silent_p.F278F			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	278					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		CCGTGTTTTTCATTCTCCCTA	0.478000													26	39					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537224	5537224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5537224G>A	ENST00000380184.1	-	1	711	c.448C>T	c.(448-450)Cac>Tac	p.H150Y	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	150										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CCCACAAAGTGGGCCAGTTCC	0.532000													9	94					0	0	1	0	0
ZW10	9183	broad.mit.edu	37	11	113614568	113614568	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113614568G>A	ENST00000200135.3	-	10	1611	c.1467C>T	c.(1465-1467)ctC>ctT	p.L489L		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	489					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TCTGATAGGCGAGTTCCATTA	0.403000													33	125					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51383417	51383417	+	Silent	SNP	G	G	A	rs139544303		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51383417G>A	ENST00000216392.7	-	9	1367	c.1035C>T	c.(1033-1035)ctC>ctT	p.L345L	PYGL_ENST00000532462.1_Silent_p.L345L|PYGL_ENST00000544180.2_Silent_p.L311L	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	345				AL -> RI (in Ref. 1; AAA52577).	glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CAGGGATCGCGAGTGCAGGGT	0.483000													39	73					0	0	1	0	0
IGHV3-23	28442	broad.mit.edu	37	14	106725467	106725467	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106725467C>T	ENST00000390609.2	-	0	163																											TGTACCAAGCCTCCCCCAGAC	0.562000													59	221					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020498	56020498	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56020498C>T	ENST00000303059.3	+	1	823	c.823C>T	c.(823-825)Cta>Tta	p.L275L		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TGGCTCTCACCTAACTGGAGT	0.408000													59	154					0	0	1	0	0
TCP10L2	401285	broad.mit.edu	37	6	167591985	167591985	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:167591985G>A	ENST00000366832.2	+	5	743	c.612G>A	c.(610-612)agG>agA	p.R204R		NM_001145121.1	NP_001138593.1	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	204										endometrium(1)|kidney(2)|lung(3)	6						CCACTGGAAGGCCGACTCCCG	0.522000													18	80					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187419802	187419802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:187419802C>T	ENST00000358241.1	-	1	543	c.115G>A	c.(115-117)Gag>Aag	p.E39K		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	39					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		GGGGCCAGCTCACTGGGCTTG	0.592000													49	181					0	0	1	0	0
IFT57	55081	broad.mit.edu	37	3	107937477	107937477	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:107937477A>G	ENST00000264538.3	-	3	646	c.399T>C	c.(397-399)ccT>ccC	p.P133P		NM_018010.3	NP_060480.1	Q9NWB7	IFT57_HUMAN	intraflagellar transport 57 homolog (Chlamydomonas)	133					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	14			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TTAATTTTGAAGGAGGAAAAT	0.328000													11	40					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119770441	119770441	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:119770441G>A	ENST00000313400.4	-	7	1621	c.1521C>T	c.(1519-1521)tcC>tcT	p.S507S	ASTN2_ENST00000361209.2_Silent_p.S456S|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Silent_p.S507S			O75129	ASTN2_HUMAN	astrotactin 2	507						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TCACCCATGGGGAGGTGGCAT	0.572000													28	50					0	0	1	0	0
OCM2	4951	broad.mit.edu	37	7	97617821	97617821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:97617821G>A	ENST00000257627.4	-	2	192	c.101C>T	c.(100-102)tCa>tTa	p.S34L	OCM2_ENST00000473987.2_5'UTR	NM_006188.3	NP_006179.2	P0CE71	OCM2_HUMAN	oncomodulin 2	34							calcium ion binding			lung(4)	4						GGAGAGGCCTGACGTCTGGAA	0.463000													90	205					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033447	82033447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82033447G>A	ENST00000328945.5	-	3	578	c.451C>T	c.(451-453)Cac>Tac	p.H151Y	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	151					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CGAGAGTAGTGATCAGGGTGG	0.507000													40	64					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595369	55595369	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55595369C>T	ENST00000378397.1	+	1	675	c.675C>T	c.(673-675)atC>atT	p.I225I		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				TCACCACTATCCTGAAGATAC	0.483000										HNSCC(27;0.073)			45	103					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54791248	54791248	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54791248G>A	ENST00000293379.4	-	29	3228	c.2967C>T	c.(2965-2967)acC>acT	p.T989T	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	989					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CTTCTGCCTTGGTCCATTGCA	0.522000													12	41					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72039235	72039235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72039235C>T	ENST00000355327.3	+	13	2229	c.2095C>T	c.(2095-2097)Cgc>Tgc	p.R699C	THSD4_ENST00000261862.6_Missense_Mutation_p.R699C|THSD4_ENST00000357769.4_Missense_Mutation_p.R339C|THSD4_ENST00000567838.1_3'UTR			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	699	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CATGCAGCACCGCCAGGTTCT	0.622000													12	72					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127797208	127797208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:127797208C>T	ENST00000556132.1	-	6	2827	c.1963G>A	c.(1963-1965)Gag>Aag	p.E655K	SOGA3_ENST00000368268.2_Missense_Mutation_p.E655K|SOGA3_ENST00000525778.1_Missense_Mutation_p.E655K|SOGA3_ENST00000481848.2_Missense_Mutation_p.E655K|SOGA3_ENST00000465909.2_Missense_Mutation_p.E655K	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	655						integral to membrane											AGCTCCGTCTCGTCTTCCACC	0.632000													9	60					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43816702	43816702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43816702C>T	ENST00000382031.1	+	5	3776	c.3745C>T	c.(3745-3747)Cat>Tat	p.H1249Y	MAP1A_ENST00000399453.1_Missense_Mutation_p.H1011Y|MAP1A_ENST00000300231.5_Missense_Mutation_p.H1011Y			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1011						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CACACCCTTTCATCAGTCCCC	0.572000													32	74					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69445293	69445293	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:69445293C>T	ENST00000337103.4	+	6	2273	c.681C>T	c.(679-681)ctC>ctT	p.L227L	C8orf34_ENST00000539993.1_Silent_p.L252L|C8orf34_ENST00000518698.1_Silent_p.L338L|C8orf34_ENST00000348340.2_Silent_p.L252L			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	252					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCGCAATGCTCTCTCAAGATT	0.373000													45	118					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45695845	45695845	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:45695845C>T	ENST00000303230.4	-	1	408	c.351G>A	c.(349-351)caG>caA	p.Q117Q		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	117	Involved in subunit assembly (By similarity).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CCACCGCCTTCTGGCTCCCAA	0.602000													15	59					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155757553	155757553	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155757553G>A	ENST00000159060.2	-	7	899	c.798_splice	c.e7+1	p.S266_splice		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	266	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CATTCTTACCGAGGGTTCCTT	0.438000													32	65					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4356353	4356353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4356353G>A	ENST00000355530.2	+	8	1246	c.966G>A	c.(964-966)ggG>ggA	p.G322G	SPNS3_ENST00000576069.1_3'UTR|SPNS3_ENST00000333476.2_Silent_p.G195G	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	322					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GCGTCATTGGGGTCATCTTGG	0.587000													36	58					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115226835	115226835	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115226835C>T	ENST00000369538.3	-	4	666	c.619G>A	c.(619-621)Gag>Aag	p.E207K	AMPD1_ENST00000353928.6_Missense_Mutation_p.E178K|AMPD1_ENST00000520113.2_Missense_Mutation_p.E211K	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	178					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TAGAAGCTCTCATTTGCTACC	0.338000													51	88					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107710318	107710318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107710318G>A	ENST00000388781.3	-	18	2220	c.2137C>T	c.(2137-2139)Ccc>Tcc	p.P713S	LAMB4_ENST00000205386.4_Missense_Mutation_p.P713S|LAMB4_ENST00000388780.3_Missense_Mutation_p.P713S	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	713	Laminin IV type B.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TTGATTTGGGGAATAAGGCCA	0.358000													28	69					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1732664	1732664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1732664C>T	ENST00000313288.4	+	5	1542	c.1436C>T	c.(1435-1437)gCc>gTc	p.A479V		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	479						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CAGTTGGCAGCCGAGACCCCA	0.632000													6	53					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28493824	28493824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28493824C>T	ENST00000412168.2	+	1	123	c.34C>T	c.(34-36)Ccc>Tcc	p.P12S	GPX6_ENST00000483058.1_Intron|GPX5_ENST00000469384.1_Missense_Mutation_p.P12S	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	12					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	CCATCTGCTTCCCCTTCTCCT	0.498000													79	168					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1808329	1808329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1808329C>T	ENST00000340107.4	+	16	2349	c.2093C>T	c.(2092-2094)cCc>cTc	p.P698L	FGFR3_ENST00000481110.2_Silent_p.P673P|FGFR3_ENST00000440486.2_Missense_Mutation_p.P696L|FGFR3_ENST00000412135.2_Missense_Mutation_p.P584L|FGFR3_ENST00000260795.2_Missense_Mutation_p.P696L|FGFR3_ENST00000352904.1_Missense_Mutation_p.P584L	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	696	Protein kinase.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TCCCCGTACCCCGGCATCCCT	0.647000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				13	47					0	0	1	0	0
SS18	6760	broad.mit.edu	37	18	23612462	23612462	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:23612462A>G	ENST00000415083.2	-	10	1186	c.1131T>C	c.(1129-1131)ccT>ccC	p.P377P	SS18_ENST00000545952.1_Silent_p.P294P|SS18_ENST00000542743.1_Silent_p.P294P|SS18_ENST00000542420.2_Silent_p.P354P|SS18_ENST00000269137.7_Silent_p.P346P|SS18_ENST00000539849.1_Silent_p.P295P	NM_001007559.1|NM_005637.2	NP_001007560.1|NP_005628.2	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	377	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX2(706)|SS18/SSX1(1169)|SS18/SSX4(12)	endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(1)	19	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					GTGGGTAGTTAGGATACTGAG	0.498000			T	"""SSX1,  SSX2"""	synovial sarcoma								24	105					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065396	9065396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9065396G>A	ENST00000397910.4	-	3	22253	c.22050C>T	c.(22048-22050)tcC>tcT	p.S7350S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7352	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTATTACCAAGGAGGGAGTGG	0.488000													16	45					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68995622	68995622	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68995622G>A	ENST00000288368.4	+	18	2303	c.2027_splice	c.e18+1	p.E676_splice	RP11-403D15.2_ENST00000526901.1_RNA|PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	676					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AAAGCCAAGAGAGTAAGTTGT	0.318000													19	56					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58512360	58512360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58512360C>T	ENST00000302819.5	-	10	1470	c.1179G>A	c.(1177-1179)atG>atA	p.M393I	ACOX2_ENST00000459701.2_Missense_Mutation_p.M379I	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	393					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TCATGGCCTTCATGCCCGTGC	0.607000													8	57					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135347379	135347379	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:135347379C>T	ENST00000463117.2	+	8	1217	c.945C>T	c.(943-945)ctC>ctT	p.L315L	SPRN_ENST00000541506.1_Intron|CYP2E1_ENST00000252945.3_Silent_p.L315L			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	315					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	TCCTGATTCTCATGAAATACC	0.542000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				28	62					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73822580	73822580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73822580C>T	ENST00000373109.2	-	11	1657	c.1213G>A	c.(1213-1215)Gag>Aag	p.E405K	SPOCK2_ENST00000317376.4_Missense_Mutation_p.E405K|SPOCK2_ENST00000536168.1_Missense_Mutation_p.E405K	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	405	Glu-rich.				extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						tcggcctcctcgcctgcttcc	0.662000													7	21					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57399115	57399115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57399115G>A	ENST00000543257.1	-	11	1855	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F	C8B_ENST00000371237.4_Missense_Mutation_p.S482F|C8B_ENST00000535057.1_Missense_Mutation_p.S420F	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	482	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						CACTGTGCTGGAATAGGCAAA	0.473000													18	45					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62933664	62933664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62933664G>A	ENST00000306494.6	-	7	1136	c.1137C>T	c.(1135-1137)ttC>ttT	p.F379F	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	379					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						TCTGCAACAGGAAAACATTGT	0.478000													25	64					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173517593	173517593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173517593C>T	ENST00000367714.3	-	12	1818	c.1396G>A	c.(1396-1398)Gaa>Aaa	p.E466K	SLC9C2_ENST00000466087.1_5'UTR|SLC9C2_ENST00000536496.1_Missense_Mutation_p.E364K	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	466					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										AAAATTTTTTCTGTTTTAAAT	0.348000													22	60					0	0	1	0	0
LINC00661	126536	broad.mit.edu	37	19	16131429	16131429	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16131429G>A	ENST00000549354.1	+	0	260				AC004790.3_ENST00000592886.1_lincRNA	NR_026828.1																						CAGTGCCCTGGAAGTGAAGGT	0.622000													13	28					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130878039	130878039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130878039G>A	ENST00000357462.5	-	1	143	c.50C>T	c.(49-51)cCa>cTa	p.P17L	POTEF_ENST00000360967.5_Missense_Mutation_p.P17L|POTEF_ENST00000409914.2_Missense_Mutation_p.P17L|POTEF_ENST00000361163.4_Missense_Mutation_p.P17L			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	17						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GAGACCAAATGGCTTCTTCAC	0.562000													18	184					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587813	247587813	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247587813G>A	ENST00000366497.2	+	4	1848	c.1068G>A	c.(1066-1068)gaG>gaA	p.E356E	NLRP3_ENST00000391828.3_Silent_p.E356E|NLRP3_ENST00000336119.3_Silent_p.E356E|NLRP3_ENST00000391827.2_Silent_p.E356E|NLRP3_ENST00000348069.2_Silent_p.E356E|NLRP3_ENST00000366496.2_Silent_p.E356E|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	356	NACHT.		E -> D (in CINCA).		detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGGCCCTGGAGAAACTGCAGC	0.552000													23	76					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17682618	17682618	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17682618G>A	ENST00000375448.4	+	12	1477	c.1451G>A	c.(1450-1452)aGg>aAg	p.R484K	PADI4_ENST00000487048.1_3'UTR	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	484					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GCACCCGACAGGAAGGTACAG	0.592000													14	46					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411681	23411681	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23411681C>T	ENST00000379361.4	+	3	2906	c.2046C>T	c.(2044-2046)ttC>ttT	p.F682F		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	682					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TCATCGTCTTCAATCCGTCCT	0.493000													37	19					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151400307	151400307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151400307G>A	ENST00000271715.2	-	7	1384	c.1070C>T	c.(1069-1071)tCa>tTa	p.S357L	POGZ_ENST00000491586.1_Missense_Mutation_p.S304L|POGZ_ENST00000409503.1_Missense_Mutation_p.S348L|POGZ_ENST00000531094.1_Missense_Mutation_p.S295L|POGZ_ENST00000361398.3_Missense_Mutation_p.S304L|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000392723.1_Missense_Mutation_p.S304L|POGZ_ENST00000368863.2_Missense_Mutation_p.S262L	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	357					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACCTTTCATTGAAGACTCAGG	0.448000													6	27					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1544488	1544488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1544488C>T	ENST00000345913.4	+	16	2832	c.2741C>T	c.(2740-2742)tCg>tTg	p.S914L	TPO_ENST00000497517.2_Intron|TPO_ENST00000349624.3_Missense_Mutation_p.S741L|TPO_ENST00000382198.1_Missense_Mutation_p.S741L|TPO_ENST00000337415.3_Intron|TPO_ENST00000382201.3_Missense_Mutation_p.S857L|TPO_ENST00000329066.4_Missense_Mutation_p.S914L|TPO_ENST00000346956.3_Missense_Mutation_p.S870L	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	914					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCTCAGGACTCGGAGCAGGTG	0.652000													21	45					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15415903	15415903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:15415903G>A	ENST00000281513.5	-	44	5454	c.5429C>T	c.(5428-5430)cCt>cTt	p.P1810L	NBAS_ENST00000441750.1_Missense_Mutation_p.P1690L	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1810										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TGCTTCAAGAGGACTCATGTT	0.368000													19	77					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61990996	61990996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61990996G>A	ENST00000370263.4	-	2	353	c.132C>T	c.(130-132)ctC>ctT	p.L44L	CHRNA4_ENST00000463705.1_Intron	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	44					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AACCGGAGAAGAGTTTCTTCA	0.652000													7	77					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80770937	80770937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80770937C>T	ENST00000458043.2	+	57	6795	c.6789C>T	c.(6787-6789)atC>atT	p.I2263I	OTOGL_ENST00000546620.1_Silent_p.I282I|OTOGL_ENST00000547103.1_Silent_p.I2251I	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						AGAAAGTGATCATTAAATCGG	0.308000													10	32					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61261588	61261588	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61261588G>A	ENST00000344731.5	+	6	574		c.e6-1		SERPINB13_ENST00000269489.5_Splice_Site	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13						regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						TTCATTTGCAGAAAAAATCAA	0.383000													10	45					0	0	1	0	0
PKN1	5585	broad.mit.edu	37	19	14568910	14568910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14568910C>T	ENST00000242783.6	+	8	1398	c.1233C>T	c.(1231-1233)ggC>ggT	p.G411G	PKN1_ENST00000342216.4_Silent_p.G417G	NM_002741.3	NP_002732.3	Q16512	PKN1_HUMAN	protein kinase N1	411	C2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)	31						AGCCATGTGGCCCCAATGCCT	0.577000													43	200					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42992602	42992602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42992602C>T	ENST00000253408.5	-	1	318	c.253G>A	c.(253-255)Gag>Aag	p.E85K	GFAP_ENST00000435360.2_Missense_Mutation_p.E85K|GFAP_ENST00000586793.1_Missense_Mutation_p.E85K|GFAP_ENST00000591327.1_5'UTR|GFAP_ENST00000588735.1_Intron	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	85	Coil 1A.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				CGAACCTTCTCGATGTAGCTG	0.602000													22	27					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20328616	20328616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20328616G>A	ENST00000302555.5	-	8	1484	c.1335C>T	c.(1333-1335)ttC>ttT	p.F445F	GP2_ENST00000341642.5_Silent_p.F298F|GP2_ENST00000381360.5_Silent_p.F301F|GP2_ENST00000381362.4_Silent_p.F448F			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	448	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CAGCAAACATGAACATCTGAA	0.488000													9	81					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92088157	92088157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92088157C>T	ENST00000298047.6	+	1	2896	c.2879C>T	c.(2878-2880)aCc>aTc	p.T960I	FAT3_ENST00000525166.1_Missense_Mutation_p.T810I|FAT3_ENST00000409404.2_Missense_Mutation_p.T960I|FAT3_ENST00000541502.1_Missense_Mutation_p.T960I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	960	Cadherin 9.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.T960S(1)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGCTTGAGACCCATGATCCA	0.468000										TCGA Ovarian(4;0.039)			29	76					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38885838	38885838	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38885838G>A	ENST00000359357.3	+	68	10049	c.9795G>A	c.(9793-9795)ggG>ggA	p.G3265G	DNAH8_ENST00000441566.1_Silent_p.G3229G|DNAH8_ENST00000449981.2_Silent_p.G3482G					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AAGTCTGTGGGAATGTGGCTG	0.388000													26	66					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39991461	39991461	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39991461C>T	ENST00000332312.3	-	4	940	c.748G>A	c.(748-750)Gag>Aag	p.E250K		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	250						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				CTTAGGATCTCGTCTAAGGGA	0.602000													18	55					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130312089	130312089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130312089G>A	ENST00000358511.6	+	16	4494	c.4463G>A	c.(4462-4464)gGa>gAa	p.G1488E	COL6A6_ENST00000453409.2_Missense_Mutation_p.G1488E	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1488	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GGAGATGAGGGATCTCAGGTA	0.363000													15	54					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605290	171605290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171605290G>A	ENST00000037502.5	-	3	1349	c.1290C>T	c.(1288-1290)ttC>ttT	p.F430F		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	430	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CACAGATGATGAAGGCATTGG	0.507000													47	131					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31475943	31475943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31475943C>T	ENST00000457010.2	+	4	2300	c.1599C>T	c.(1597-1599)tcC>tcT	p.S533S	ARMC5_ENST00000563544.1_Silent_p.S533S|ARMC5_ENST00000268314.4_Silent_p.S533S|ARMC5_ENST00000408912.3_Silent_p.S628S|ARMC5_ENST00000412665.2_Silent_p.S177S|ARMC5_ENST00000538189.1_Silent_p.S565S	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	533							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CGCGCTTTTCCCAGGCCCCTG	0.731000													8	11					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61844941	61844941	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61844941G>A	ENST00000280772.1	-	31	4010	c.3819C>T	c.(3817-3819)gtC>gtT	p.V1273V	ANK3_ENST00000355288.2_Silent_p.V407V|ANK3_ENST00000503366.1_Silent_p.V1274V|ANK3_ENST00000373827.2_Silent_p.V1267V	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1273					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTGTAAAGGAGACACAATCTT	0.383000													28	87					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21991161	21991161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21991161G>A	ENST00000594012.1	-	7	2174	c.1660C>T	c.(1660-1662)Cat>Tat	p.H554Y	ZNF43_ENST00000354959.4_Missense_Mutation_p.H560Y|ZNF43_ENST00000595461.1_Missense_Mutation_p.H554Y|ZNF43_ENST00000598381.1_Missense_Mutation_p.H554Y	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TCTCCAGTATGAATCCTCTTA	0.363000													37	69					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47506910	47506910	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47506910G>A	ENST00000285039.7	-	9	1259	c.960C>T	c.(958-960)tcC>tcT	p.S320S		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	320	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TCATCTGATGGGACTCTTTCA	0.393000													9	52					0	0	1	0	0
VRK2	7444	broad.mit.edu	37	2	58359011	58359011	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:58359011C>T	ENST00000435505.2	+	12	1490	c.745C>T	c.(745-747)Ccc>Tcc	p.P249S	VRK2_ENST00000417641.2_Missense_Mutation_p.P249S|VRK2_ENST00000340157.4_Missense_Mutation_p.P249S|VRK2_ENST00000440705.2_Missense_Mutation_p.P226S|VRK2_ENST00000412104.2_Missense_Mutation_p.P249S			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	249	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						TGGGAAACTTCCCTGGGAACA	0.473000													38	84					0	0	1	0	0
TKT	7086	broad.mit.edu	37	3	53263106	53263106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53263106G>A	ENST00000462138.1	-	10	1400	c.1312C>T	c.(1312-1314)Cgg>Tgg	p.R438W	TKT_ENST00000296289.6_Missense_Mutation_p.R391W|TKT_ENST00000423516.1_Missense_Mutation_p.R446W|TKT_ENST00000461139.1_5'UTR|TKT_ENST00000423525.2_Missense_Mutation_p.R438W			P29401	TKT_HUMAN	transketolase	438					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	GGGACTGACCGAAACATAGCC	0.542000													62	150					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052360	44052360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:44052360G>A	ENST00000306006.6	-	2	1820	c.1168C>T	c.(1168-1170)Ctt>Ttt	p.L390F	ZNF239_ENST00000374446.2_Missense_Mutation_p.L390F|ZNF239_ENST00000535642.1_Missense_Mutation_p.L390F|ZNF239_ENST00000426961.1_Missense_Mutation_p.L390F	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGGATGCGAAGATCCGAGCTC	0.527000													8	78					0	0	1	0	0
QRFPR	84109	broad.mit.edu	37	4	122250491	122250491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122250491G>A	ENST00000394427.2	-	6	1685	c.1274C>T	c.(1273-1275)tCt>tTt	p.S425F	QRFPR_ENST00000334383.5_3'UTR	NM_198179.2	NP_937822.2	Q96P65	QRFPR_HUMAN	pyroglutamylated RFamide peptide receptor	425						plasma membrane	neuropeptide Y receptor activity			endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(2)|skin(3)|stomach(1)	28						GTCTAAAGGAGAATTCTCAGC	0.363000													25	109					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55874940	55874940	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55874940T>A	ENST00000388975.3	-	8	945	c.829A>T	c.(829-831)Aat>Tat	p.N277Y		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	277					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCACAGTGATTTTCATTTTCC	0.308000													23	44					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3116432	3116432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3116432C>T	ENST00000400569.3	-	21	3533	c.3200G>A	c.(3199-3201)cGg>cAg	p.R1067Q	MYOM1_ENST00000261606.7_Missense_Mutation_p.R971Q|MYOM1_ENST00000356443.4_Missense_Mutation_p.R1067Q			P52179	MYOM1_HUMAN	myomesin 1	1067	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GACCGGAGTCCGCCCGGAGTG	0.552000													10	21					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131117932	131117932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131117932C>T	ENST00000300456.3	+	12	1748	c.1631C>T	c.(1630-1632)aCc>aTc	p.T544I	SLC27A4_ENST00000372870.1_Missense_Mutation_p.T138I	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	544					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						CCCCCAGGAACCGAGGGCCGG	0.657000													19	72					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89347138	89347138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89347138G>A	ENST00000301030.4	-	9	6272	c.5812C>T	c.(5812-5814)Ccc>Tcc	p.P1938S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1938S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1938	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCGCTGAAGGGACCCTCGTCC	0.697000													20	47					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10084736	10084736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:10084736G>A	ENST00000382452.2	-	10	1388	c.1106C>T	c.(1105-1107)tCc>tTc	p.S369F	WDR1_ENST00000499869.2_Missense_Mutation_p.S369F|WDR1_ENST00000502702.1_Missense_Mutation_p.S229F|WDR1_ENST00000382451.2_Missense_Mutation_p.S229F|WDR1_ENST00000515743.1_5'UTR	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	369					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		GGTCATCCTGGACACCTGGTT	0.602000													13	27					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42571329	42571329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42571329C>T	ENST00000372901.1	+	5	793	c.535C>T	c.(535-537)Cct>Tct	p.P179S	UBR2_ENST00000372899.1_Missense_Mutation_p.P179S|UBR2_ENST00000372903.2_Missense_Mutation_p.P179S			Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	179					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			ctttCAGGATCCTCTTGTTCA	0.303000													14	19					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65413779	65413779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65413779C>T	ENST00000394224.3	+	7	1647	c.1351C>T	c.(1351-1353)Cgc>Tgc	p.R451C	SIPA1_ENST00000394227.3_Missense_Mutation_p.R451C|SIPA1_ENST00000534313.1_Missense_Mutation_p.R451C|SIPA1_ENST00000527525.1_Missense_Mutation_p.R451C	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	451	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						CACCACCATCCGCTCGCACTT	0.632000													36	88					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6924124	6924124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6924124G>A	ENST00000011653.4	+	5	831	c.573G>A	c.(571-573)aaG>aaA	p.K191K	CD4_ENST00000541982.1_Silent_p.K136K|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	191	Ig-like C2-type 1.		K -> E (in dbSNP:rs28917504).		cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				AGAACCAGAAGAAGGTGGAGT	0.577000													6	31					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19701585	19701585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:19701585C>T	ENST00000284885.3	-	15	1714	c.1681G>A	c.(1681-1683)Gga>Aga	p.G561R		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	561	CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						ATATTCTTTCCTTTTTGTGCA	0.308000													13	39					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476041	120476041	+	Silent	SNP	C	C	T	rs140976297		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:120476041C>T	ENST00000355622.6	+	3	1736	c.1635C>T	c.(1633-1635)tcC>tcT	p.S545S	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.S505S	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	545					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GTCTGAACTCCCTCCAGGTTC	0.378000													11	55					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79092621	79092621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79092621G>A	ENST00000388820.4	-	2	579	c.369C>T	c.(367-369)gcC>gcT	p.A123A	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	123					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CCGGGGTGTGGGCCCGGATGT	0.731000													8	29					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30126365	30126365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30126365G>A	ENST00000449742.2	-	3	642	c.567C>T	c.(565-567)ttC>ttT	p.F189F	TRIM10_ENST00000376704.3_Silent_p.F189F	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	189						cytoplasm	zinc ion binding	p.F189F(1)		ovary(1)	1						TCAGGTGTGCGAACTCAGAAA	0.517000													100	225					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48117823	48117823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48117823C>T	ENST00000311303.3	-	28	4335	c.3990G>A	c.(3988-3990)ggG>ggA	p.G1330G	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1330	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CCTATACCTTCCCATTTTCCA	0.483000													26	84					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35667306	35667306	+	Missense_Mutation	SNP	G	G	A	rs144477950		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35667306G>A	ENST00000440995.2	+	9	1300	c.1300G>A	c.(1300-1302)Gat>Aat	p.D434N	SPEF2_ENST00000356031.3_Missense_Mutation_p.D434N|SPEF2_ENST00000282469.6_Missense_Mutation_p.D434N|SPEF2_ENST00000509059.1_Missense_Mutation_p.D434N			Q9C093	SPEF2_HUMAN	sperm flagellar 2	434					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGAAATTTTGGATCAAATAGT	0.328000													17	38					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34092618	34092618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34092618C>T	ENST00000397527.1	+	30	7141	c.6421C>T	c.(6421-6423)Ctt>Ttt	p.L2141F	CEP250_ENST00000342580.4_Missense_Mutation_p.L2085F	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	2141	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			ATCTCTAAAACTTGATTCTTT	0.557000													7	95					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104239033	104239033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104239033G>A	ENST00000374851.1	-	4	1489	c.342C>T	c.(340-342)ggC>ggT	p.G114G	RP11-490D19.6_ENST00000431507.1_RNA|TMEM246_ENST00000374847.1_Silent_p.G114G|RP11-490D19.6_ENST00000450109.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000424154.1_RNA|TMEM246_ENST00000374848.3_Silent_p.G114G			Q9BRR3	CI125_HUMAN	transmembrane protein 246	114						integral to membrane											CGTAGTGGAAGCCAGGCTGCC	0.622000													5	54					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73235205	73235205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:73235205G>A	ENST00000377110.2	-	15	2123	c.1880C>T	c.(1879-1881)cCt>cTt	p.P627L	TRPM3_ENST00000396292.4_Missense_Mutation_p.P499L|TRPM3_ENST00000360823.2_Missense_Mutation_p.P489L|TRPM3_ENST00000423814.3_Missense_Mutation_p.P654L|TRPM3_ENST00000396285.1_Missense_Mutation_p.P474L|TRPM3_ENST00000358082.3_Missense_Mutation_p.P489L|TRPM3_ENST00000357533.2_Missense_Mutation_p.P631L|TRPM3_ENST00000377105.1_Missense_Mutation_p.P486L|TRPM3_ENST00000377106.1_Missense_Mutation_p.P499L|TRPM3_ENST00000396280.5_Missense_Mutation_p.P476L|TRPM3_ENST00000377111.2_Missense_Mutation_p.P627L|TRPM3_ENST00000408909.2_Missense_Mutation_p.P486L	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	652						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GTTGATCTCAGGATCATCCAA	0.498000													48	157					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073120	17073120	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17073120G>A	ENST00000359963.3	-	1	580	c.321C>T	c.(319-321)ttC>ttT	p.F107F		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	107					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.F107F(1)		breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCAGAACCACGAAGGCTGTGC	0.662000													20	64					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240674	39240674	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39240674G>A	ENST00000391417.4	+	1	216	c.216G>A	c.(214-216)acG>acA	p.T72T		NM_033061.3	NP_149050.3			keratin associated protein 4-7											NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GCTGTGAGACGACctgctgcc	0.657000													13	31					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14809496	14809496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14809496C>T	ENST00000261170.3	-	12	1556	c.1420G>A	c.(1420-1422)Gaa>Aaa	p.E474K		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	474					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AAGATATTTTCAGGAGGAATG	0.358000													34	107					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69416504	69416504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69416504C>T	ENST00000317746.2	-	5	1246	c.1204G>A	c.(1204-1206)Gat>Aat	p.D402N		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	402					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						GCAATGTTATCATGTTGATCC	0.448000													53	143					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976700	20976700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20976700C>T	ENST00000261383.3	-	53	8505	c.8506G>A	c.(8506-8508)Gat>Aat	p.D2836N	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2836	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AATTTCAGATCCCCAAGAATC	0.413000													19	91					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110295781	110295781	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110295781G>A	ENST00000369805.3	-	13	1390	c.1161C>T	c.(1159-1161)ccC>ccT	p.P387P	EPS8L3_ENST00000361965.4_Silent_p.P386P|RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361852.4_Silent_p.P386P	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	386						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CTGAGAATGTGGGTTGGTAGG	0.572000													11	87					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123452725	123452725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123452725C>T	ENST00000360772.3	-	11	1496	c.1118G>A	c.(1117-1119)aGg>aAg	p.R373K	MYLK_ENST00000360304.3_Missense_Mutation_p.R373K|MYLK_ENST00000475616.1_Missense_Mutation_p.R373K|MYLK_ENST00000346322.5_Missense_Mutation_p.R373K|MYLK_ENST00000359169.1_Missense_Mutation_p.R373K			Q15746	MYLK_HUMAN	myosin light chain kinase	373					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGGAGCTGGCCTCTTCCTCTC	0.612000													38	103					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101523896	101523896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101523896C>T	ENST00000388948.3	+	4	784	c.425C>T	c.(424-426)tCc>tTc	p.S142F	LRRK1_ENST00000532029.2_Missense_Mutation_p.S142F|LRRK1_ENST00000284395.5_Intron	NM_024652.3	NP_078928.3	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	142					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTGCTTGAGTCCTTACCAGGT	0.527000													25	78					0	0	1	0	0
GJB2	2706	broad.mit.edu	37	13	20763615	20763615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:20763615G>A	ENST00000382844.1	-	1	304	c.106C>T	c.(106-108)Ctc>Ttc	p.L36F	GJB2_ENST00000382848.4_Missense_Mutation_p.L36F			P29033	CXB2_HUMAN	gap junction protein, beta 2, 26kDa	36					cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane				breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		GCCACAACGAGGATCATAATG	0.542000									Keratitis, Ichthyosis and Deafness syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	86					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23203759	23203759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23203759G>A	ENST00000300061.2	+	4	848	c.705G>A	c.(703-705)atG>atA	p.M235I		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	235					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TACACTACATGAACATCATGG	0.488000													11	91					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72848173	72848173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72848173G>A	ENST00000293190.5	-	3	1123	c.977C>T	c.(976-978)cCt>cTt	p.P326L	GRIN2C_ENST00000347612.4_Missense_Mutation_p.P326L	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	326					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CTCCCGGGCAGGGCTGACGGG	0.716000													5	15					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57865164	57865164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57865164C>T	ENST00000228682.2	+	12	2732	c.2641C>T	c.(2641-2643)Ctg>Ttg	p.L881L	GLI1_ENST00000546141.1_Silent_p.L840L|GLI1_ENST00000543426.1_Silent_p.L753L	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	881					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			CAGGCCTTGCCTGGACTTTGA	0.552000													17	132					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246811221	246811221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:246811221C>T	ENST00000366513.4	+	9	1987	c.1718C>T	c.(1717-1719)tCc>tTc	p.S573F	CNST_ENST00000366512.3_Missense_Mutation_p.S573F|CNST_ENST00000483271.1_3'UTR	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	573					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						GACGACGACTCCGATCTCCTT	0.408000													53	237					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57569316	57569316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57569316C>T	ENST00000243077.3	+	23	4087	c.3621C>T	c.(3619-3621)tcC>tcT	p.S1207S		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1207	EGF-like 5.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTGTGTGTTCCTGCCCTCTGG	0.582000											OREG0021937	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	67					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156756843	156756843	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156756843C>T	ENST00000271526.4	+	3	1232	c.960C>T	c.(958-960)ccC>ccT	p.P320P	PRCC_ENST00000353233.3_Silent_p.P320P|PRCC_ENST00000491853.1_3'UTR	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	320					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCAATGCCCCCCTTGAATTCA	0.572000			T	TFE3	papillary renal								82	168					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31523087	31523087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31523087G>A	ENST00000261592.5	-	9	1781	c.1484C>T	c.(1483-1485)tCa>tTa	p.S495L	NOL4_ENST00000535475.1_Missense_Mutation_p.S276L|NOL4_ENST00000269185.4_Intron|NOL4_ENST00000535384.1_Missense_Mutation_p.S210L|NOL4_ENST00000538587.1_Missense_Mutation_p.S421L|NOL4_ENST00000589544.1_Intron	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	495						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						CTCACAAGCTGAAGCCAAGAT	0.423000													20	81					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33235498	33235498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33235498G>A	ENST00000401073.2	+	6	788	c.718G>A	c.(718-720)Gag>Aag	p.E240K	KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373481.3_Missense_Mutation_p.E192K|KIAA1522_ENST00000373480.1_Missense_Mutation_p.E181K	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	181										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GAATGAGCGTGAGGCACCAGG	0.701000													8	25					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120935629	120935629	+	Missense_Mutation	SNP	C	C	T	rs147434701	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120935629C>T	ENST00000310396.5	+	23	3471	c.3004C>T	c.(3004-3006)Cat>Tat	p.H1002Y		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		ATCGCCATATCATGTCAGAGG	0.378000													45	104					0	0	1	0	0
OR6C75	390323	broad.mit.edu	37	12	55758950	55758950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55758950C>T	ENST00000343399.3	+	1	56	c.56C>T	c.(55-57)cCa>cTa	p.P19L		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						ACAAGTGACCCACAGTGGCAG	0.363000													56	183					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120263021	120263021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120263021G>A	ENST00000392521.2	-	8	960	c.905C>T	c.(904-906)cCc>cTc	p.P302L	CIT_ENST00000261833.7_Missense_Mutation_p.P302L	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	302	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTCTGCGAAGGGGGATCTCCC	0.468000													35	73					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68968190	68968190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68968190C>T	ENST00000288368.4	+	10	1496	c.1219C>T	c.(1219-1221)Cct>Tct	p.P407S	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	407	DEP 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GACTACGTTCCCTAAATGCTT	0.398000													41	73					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112162920	112162920	+	Nonstop_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:112162920G>C	ENST00000520401.1	+	1	11	c.11G>C	c.(10-12)tGa>tCa	p.*4S	APC_ENST00000457016.1_Missense_Mutation_p.L508F|APC_ENST00000508376.2_Missense_Mutation_p.L508F|APC_ENST00000257430.4_Missense_Mutation_p.L508F														p.?(1)									TGACAAACTTGACTTTTGGAG	0.333000													8	80					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14565186	14565186	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14565186C>T	ENST00000273083.3	-	0	488							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						TTGAAATGATCCTGGGGTTAT	0.517000													8	19					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70516049	70516049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70516049C>T	ENST00000265872.6	+	14	1764	c.1645C>T	c.(1645-1647)Cgc>Tgc	p.R549C	CCAR1_ENST00000483264.1_3'UTR|CCAR1_ENST00000543719.1_Missense_Mutation_p.R534C|CCAR1_ENST00000535016.1_Missense_Mutation_p.R534C	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	549					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						TGCAGAGATTCGCTACCATCG	0.453000													31	57					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648300	112648300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112648300G>A	ENST00000471858.1	-	3	420	c.188C>T	c.(187-189)cCt>cTt	p.P63L	CD200R1_ENST00000308611.3_Missense_Mutation_p.P86L|CD200R1_ENST00000440122.2_Missense_Mutation_p.P86L|CD200R1_ENST00000295863.4_Missense_Mutation_p.P41L|CD200R1_ENST00000490004.1_Missense_Mutation_p.P63L	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	63	Ig-like V-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TAATGCGATAGGAGGGCAACA	0.383000													23	105					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751819	26751819	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:26751819C>T	ENST00000396641.2	+	2	1248	c.656C>T	c.(655-657)tCa>tTa	p.S219L	LRRC3B_ENST00000456208.2_Missense_Mutation_p.S219L|LRRC3B_ENST00000417744.1_Missense_Mutation_p.S219L	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	219						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						ATGGTGATCTCATATGTGGTA	0.468000													11	30					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2020459	2020459	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2020459C>T	ENST00000262113.4	+	9	969	c.828C>T	c.(826-828)ttC>ttT	p.F276F	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	276	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		ACACGCACTTCGACGTCCAGT	0.567000													8	57					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123369776	123369776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:123369776C>T	ENST00000275162.4	+	4	1909	c.574C>T	c.(574-576)Cca>Tca	p.P192S	CLVS2_ENST00000368438.1_Missense_Mutation_p.P46S	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	192	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						GGATAGTTTCCCAGCGCGATT	0.378000													23	62					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200965372	200965372	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200965372C>T	ENST00000332129.2	-	15	2545	c.2229G>A	c.(2227-2229)agG>agA	p.R743R	KIF21B_ENST00000360529.5_Silent_p.R743R|KIF21B_ENST00000461742.2_Silent_p.R743R|KIF21B_ENST00000422435.2_Silent_p.R743R	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	743					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TCTTCAGCTCCCTCTCGTAGC	0.612000													74	204					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402151	89402151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89402151G>A	ENST00000439576.2	+	12	6709	c.6335G>A	c.(6334-6336)gGg>gAg	p.G2112E	ACAN_ENST00000352105.7_Missense_Mutation_p.G2112E|ACAN_ENST00000559004.1_Missense_Mutation_p.G2112E|ACAN_ENST00000561243.1_Missense_Mutation_p.G2112E	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2112					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCTGGGTTCGGGGCATCTGCC	0.552000													21	80					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103897786	103897786	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103897786C>T	ENST00000278070.2	+	2	372	c.333C>T	c.(331-333)agC>agT	p.S111S	PPRC1_ENST00000413464.2_Silent_p.S111S	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	111					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		ATTTTGGGAGCCTTGGAGAGG	0.527000													18	32					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130220636	130220636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130220636G>A	ENST00000276211.5	+	11	1828	c.1483G>A	c.(1483-1485)Gaa>Aaa	p.E495K	ARHGAP36_ENST00000370921.1_Missense_Mutation_p.E359K|ARHGAP36_ENST00000370922.1_Missense_Mutation_p.E483K	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	495					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GCCTTCTGATGAAGGTCAGTT	0.537000													20	19					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179580269	179580269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179580269G>A	ENST00000589042.1	-	89	26096	c.25872C>T	c.(25870-25872)gcC>gcT	p.A8624A	TTN_ENST00000342992.6_Silent_p.A7380A|TTN_ENST00000591111.1_Silent_p.A8307A|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8307	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCATTGTGGGCCTCACAGG	0.478000													5	78					0	0	1	0	0
MYOZ2	51778	broad.mit.edu	37	4	120085516	120085516	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:120085516A>T	ENST00000307128.5	+	5	740	c.527A>T	c.(526-528)aAg>aTg	p.K176M		NM_016599.4	NP_057683.1	Q9NPC6	MYOZ2_HUMAN	myozenin 2	176							protein phosphatase 2B binding			endometrium(1)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						CCTGAAGGAAAGGCAGAACTG	0.423000													27	76					0	0	1	0	0
SERINC5	256987	broad.mit.edu	37	5	79498730	79498730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79498730G>A	ENST00000507668.2	-	2	320	c.170C>T	c.(169-171)aCc>aTc	p.T57I	SERINC5_ENST00000513907.1_5'UTR|SERINC5_ENST00000512972.2_Missense_Mutation_p.T57I|SERINC5_ENST00000509193.1_Missense_Mutation_p.T57I|SERINC5_ENST00000512721.1_Missense_Mutation_p.T57I	NM_001174071.1|NM_178276.5	NP_001167542.1|NP_840060.1	Q86VE9	SERC5_HUMAN	serine incorporator 5	57					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|kidney(1)|lung(3)|ovary(1)	8		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GTGAGCCACGGTTGTTGACAT	0.502000													10	24					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098412	144098412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:144098412C>T	ENST00000467773.1	-	4	570	c.571G>A	c.(571-573)Gag>Aag	p.E191K	NOBOX_ENST00000223140.5_Missense_Mutation_p.E106K|NOBOX_ENST00000483238.1_Missense_Mutation_p.E191K	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	191					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					ATCTTCACCTCTCCCACTGGG	0.607000													9	12					0	0	1	0	0
OR8K5	219453	broad.mit.edu	37	11	55926894	55926894	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55926894G>T	ENST00000313447.1	-	1	899	c.900C>A	c.(898-900)gcC>gcA	p.A300A		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GCTTATAGAAGGCATTTTTCA	0.279000													13	70					3.27435e-08	3.28482e-08	1	1	0
DCLK3	85443	broad.mit.edu	37	3	36779911	36779911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36779911G>A	ENST00000416516.2	-	2	730	c.240C>T	c.(238-240)ccC>ccT	p.P80P		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	80						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						AAAGCTCCTCGGGGATCTTCC	0.612000													73	174					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43332497	43332497	+	Silent	SNP	G	G	A	rs139545553	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43332497G>A	ENST00000380486.3	-	7	1138	c.897C>T	c.(895-897)ttC>ttT	p.F299F	C2CD2_ENST00000329623.7_Silent_p.F144F	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	299	C2.					cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						GGGTGCTGGAGAACCTCTGAA	0.498000													11	12					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76451897	76451897	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76451897C>T	ENST00000389840.5	-	63	10081	c.9957G>A	c.(9955-9957)tcG>tcA	p.S3319S	DNAH17_ENST00000586052.1_Intron|DNAH17_ENST00000585328.1_Silent_p.S3328S					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGATGTTTTCCGATGCTAATC	0.557000													8	35					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75550745	75550745	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75550745C>T	ENST00000604729.1	+	8	1251	c.954C>T	c.(952-954)tcC>tcT	p.S318S	ZSWIM8_ENST00000398706.2_Silent_p.S318S|ZSWIM8_ENST00000605216.1_Silent_p.S318S|ZSWIM8_ENST00000603114.1_Silent_p.S318S|ZSWIM8_ENST00000604524.1_Silent_p.S318S					zinc finger, SWIM-type containing 8																		ATGTGAACTCCATGTATCTGT	0.542000													24	64					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128786428	128786428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128786428C>T	ENST00000529694.1	+	3	1438	c.1062C>T	c.(1060-1062)acC>acT	p.T354T	KCNJ5_ENST00000338350.4_Silent_p.T354T|KCNJ5_ENST00000533599.1_Silent_p.T354T	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	354					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TCCATGATACCTATGAGACCA	0.577000													51	131					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976471	38976471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38976471C>T	ENST00000355481.4	+	34	5307	c.5176C>T	c.(5176-5178)Cgc>Tgc	p.R1726C	RYR1_ENST00000359596.3_Missense_Mutation_p.R1726C|RYR1_ENST00000360985.3_Missense_Mutation_p.R1726C	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1726	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTGCCGCAGCCGCCGCTCCAT	0.647000													33	69					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35556465	35556465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35556465G>A	ENST00000262626.2	+	11	1755	c.930G>A	c.(928-930)caG>caA	p.Q310Q	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Silent_p.Q152Q|HPN_ENST00000392226.1_Silent_p.Q310Q	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	310	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GGGTACTCCAGGAGGCTCGAG	0.612000													17	29					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24537774	24537774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:24537774C>T	ENST00000264463.4	-	3	748	c.241G>A	c.(241-243)Gac>Aac	p.D81N		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	81	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TTATCTTGGTCTGAATGTAGC	0.368000										HNSCC(23;0.051)			11	50					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093784	30093784	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30093784C>T	ENST00000567636.1	+	0	2159					NR_003558.1																						GGCCTCTGTTCACAACAGTAG	0.413000													4	11					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154183798	154183798	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154183798C>T	ENST00000336314.4	+	14	2270	c.2246C>T	c.(2245-2247)cCa>cTa	p.P749L		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	826							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGTTCAAACCCACCCTTGGAG	0.532000													42	117					0	0	1	0	0
SEC24B-AS1	100533182	broad.mit.edu	37	4	110268668	110268668	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110268668C>A	ENST00000499713.2	-	0	1395																											ATTCAAGCTCCAACGAGCTTG	0.527000													11	25					6.40141e-05	6.41218e-05	1	1	0
DTWD2	285605	broad.mit.edu	37	5	118176751	118176751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:118176751G>A	ENST00000304058.4	-	6	630	c.560C>T	c.(559-561)tCc>tTc	p.S187F	DTWD2_ENST00000515439.3_Missense_Mutation_p.S157F|DTWD2_ENST00000510708.1_Missense_Mutation_p.S253F			Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	253										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)	13		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		AAGTTGAAAGGAGCATAAAGC	0.373000													9	19					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43319611	43319611	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43319611C>T	ENST00000589700.1	+	5	782	c.782C>T	c.(781-783)tCc>tTc	p.S261F	SLC14A1_ENST00000321925.4_Silent_p.L310L|SLC14A1_ENST00000586142.1_Silent_p.L310L|SLC14A1_ENST00000502059.2_Silent_p.L202L|RP11-116O18.3_ENST00000586213.1_RNA|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000436407.3_Silent_p.L366L|SLC14A1_ENST00000415427.3_Silent_p.L366L|SLC14A1_ENST00000535474.1_Silent_p.L178L|SLC14A1_ENST00000402943.2_Silent_p.L205L|SLC14A1_ENST00000591541.1_Silent_p.L14L			Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	0						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						AAACCCACCTCCTGGCTCTTG	0.537000													28	69					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21695445	21695445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21695445C>T	ENST00000261195.2	-	13	1884	c.1630G>A	c.(1630-1632)Gat>Aat	p.D544N		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	544					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GCAGTAGGATCAGCCACGTGC	0.507000													10	38					0	0	1	0	0
SEC24B	10427	broad.mit.edu	37	4	110447439	110447439	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110447439C>T	ENST00000265175.5	+	17	2904	c.2849C>T	c.(2848-2850)tCc>tTc	p.S950F	SEC24B_ENST00000504968.2_Missense_Mutation_p.S980F|SEC24B_ENST00000399100.2_Missense_Mutation_p.S915F	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	950					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		GATTTGTTATCCCTTGCCAAC	0.348000													39	88					0	0	1	0	0
PAPOLG	64895	broad.mit.edu	37	2	60995608	60995608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:60995608C>T	ENST00000238714.3	+	4	499	c.250C>T	c.(250-252)Ctc>Ttc	p.L84F		NM_022894.3	NP_075045.2	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	84					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	35	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			ATTTTAGAACCTCCCACCTTC	0.383000													10	109					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3806148	3806148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:3806148C>T	ENST00000440314.2	-	4	491	c.18G>A	c.(16-18)ggG>ggA	p.G6G	EFCAB4B_ENST00000444507.1_Silent_p.G6G|EFCAB4B_ENST00000252322.1_Silent_p.G6G	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	6					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			AGACTACCCTCCCGTCAGGGG	0.572000													10	16					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628811	84628811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:84628811C>T	ENST00000284136.6	-	17	2322	c.2279G>A	c.(2278-2280)cGa>cAa	p.R760Q	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	760	Arg/Lys-rich (basic).				cell differentiation|nervous system development	extracellular region|membrane	receptor activity	p.R760Q(1)		NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TCTTCGATTTCGTTTCTTCTT	0.453000													32	78					0	0	1	0	0
DTNB	1838	broad.mit.edu	37	2	25678335	25678335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:25678335G>A	ENST00000406818.3	-	11	1357	c.1108C>T	c.(1108-1110)Cac>Tac	p.H370Y	DTNB_ENST00000404103.3_Missense_Mutation_p.H370Y|DTNB_ENST00000288642.8_Missense_Mutation_p.H370Y|DTNB_ENST00000496972.2_Missense_Mutation_p.H313Y|DTNB_ENST00000407038.3_Intron|DTNB_ENST00000407186.1_Intron|DTNB_ENST00000407661.3_Missense_Mutation_p.H370Y|DTNB_ENST00000545439.1_Missense_Mutation_p.H166Y|DTNB_ENST00000405222.1_Intron	NM_001256303.1|NM_021907.4	NP_001243232.1|NP_068707.1	O60941	DTNB_HUMAN	dystrobrevin, beta	370						cytoplasm	calcium ion binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGGCCAAGTGACTGGGTATA	0.527000													6	11					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157516898	157516898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157516898G>A	ENST00000361835.3	-	3	299	c.142C>T	c.(142-144)Cgc>Tgc	p.R48C	FCRL5_ENST00000368189.3_Missense_Mutation_p.R48C|FCRL5_ENST00000368188.2_Missense_Mutation_p.R48C|FCRL5_ENST00000368190.3_Missense_Mutation_p.R48C|FCRL5_ENST00000356953.4_Missense_Mutation_p.R48C|FCRL5_ENST00000368191.3_Intron	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	48	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity	p.R48C(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GAGTAGAAGCGAAATCCCTTG	0.478000													35	96					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196309524	196309524	+	Missense_Mutation	SNP	G	G	A	rs140538298		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196309524G>A	ENST00000367433.5	-	16	1831	c.1730C>T	c.(1729-1731)tCg>tTg	p.S577L	KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000367431.4_Missense_Mutation_p.S527L|KCNT2_ENST00000294725.8_Missense_Mutation_p.S577L|KCNT2_ENST00000451324.2_Missense_Mutation_p.S188L			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	577						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						ATGATAAAACGACCTGGACAC	0.303000													30	106					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80048890	80048890	+	Silent	SNP	G	G	A	rs145311183		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80048890G>A	ENST00000306749.2	-	10	1766	c.1548C>T	c.(1546-1548)ttC>ttT	p.F516F		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	516	Acyl and malonyl transferases (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TGGAATCTCGGAAGCGGTCCA	0.622000													19	57					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46326989	46326989	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46326989G>A	ENST00000397850.2	-	5	621	c.169C>T	c.(169-171)Cct>Tct	p.P57S	ITGB2_ENST00000397854.3_Missense_Mutation_p.P57S|ITGB2_ENST00000397857.1_Missense_Mutation_p.P57S|ITGB2_ENST00000302347.5_Missense_Mutation_p.P57S|ITGB2_ENST00000397852.1_Missense_Mutation_p.P57S|ITGB2_ENST00000355153.4_Missense_Mutation_p.P57S			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	57					apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	ATGGAGTCAGGATCCCCCGGC	0.652000													15	42					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41961632	41961632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41961632G>A	ENST00000298919.7	+	9	1123	c.735G>A	c.(733-735)gaG>gaA	p.E245E	PDZRN4_ENST00000539469.2_Silent_p.E247E|PDZRN4_ENST00000402685.2_Silent_p.E505E			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	505	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCTTAGAGGAGTTAAACTTGG	0.398000													17	77					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8399573	8399573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8399573G>A	ENST00000471889.1	+	8	2180	c.1795G>A	c.(1795-1797)Gag>Aag	p.E599K	SLC45A1_ENST00000377479.2_Missense_Mutation_p.E633K|SLC45A1_ENST00000289877.8_Missense_Mutation_p.E599K			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	599					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGCTGGAGGAGTTCCTCAG	0.652000													20	72					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41165887	41165887	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41165887G>A	ENST00000483722.1	-	2	521	c.336C>T	c.(334-336)atC>atT	p.I112I		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	112	Ig-like V-type.				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGGGGTACAGGATCCCAGAGG	0.622000													9	39					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3949503	3949503	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3949503G>A	ENST00000281228.8	-	0	706				FAM86EP_ENST00000313946.8_RNA																							GGACGGCAGAGAGCTGACAGA	0.607000													4	36					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179503926	179503926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179503926C>T	ENST00000367618.3	+	25	3247	c.2860C>T	c.(2860-2862)Cat>Tat	p.H954Y		NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	954	Glu-rich.									NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						TGAGAAACTTCATCATACCCT	0.348000													36	107					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102316	168102316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168102316G>A	ENST00000409195.1	+	9	4503	c.4414G>A	c.(4414-4416)Gaa>Aaa	p.E1472K	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1472K|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1250K|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1297					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTTAGAATATGAAAATATCAA	0.378000													31	85					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44595350	44595350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44595350G>A	ENST00000372299.3	+	2	465	c.407G>A	c.(406-408)gGa>gAa	p.G136E	KLF17_ENST00000476802.1_Intron	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	136					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					ATGCCCGTAGGAGAGCCCAAT	0.542000													36	58					0	0	1	0	0
KRT72	140807	broad.mit.edu	37	12	52979922	52979922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52979922C>T	ENST00000293745.2	-	9	1465	c.1380G>A	c.(1378-1380)ggG>ggA	p.G460G	KRT72_ENST00000537672.2_Silent_p.G460G|KRT72_ENST00000354310.4_Silent_p.G418G|KRT72_ENST00000398066.3_Silent_p.G272G	NM_080747.2	NP_542785.1	Q14CN4	K2C72_HUMAN	keratin 72	460	Tail.					keratin filament	structural molecule activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(357;0.195)		TGAAGCCAGCCCCTCCTGCCC	0.587000													9	46					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108147413	108147413	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108147413C>T	ENST00000273353.3	-	28	3744	c.3688G>A	c.(3688-3690)Gaa>Aaa	p.E1230K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1230						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TTGTCTTTTTCCAGTTTCTGC	0.488000													55	105					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207528044	207528044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207528044C>T	ENST00000452335.2	-	11	1332	c.1216G>A	c.(1216-1218)Gaa>Aaa	p.E406K		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	406						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		GGAACCTTTTCAGTTGAAGAA	0.448000													22	60					0	0	1	0	0
MRPL44	65080	broad.mit.edu	37	2	224824592	224824592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:224824592C>T	ENST00000258383.3	+	2	590	c.521C>T	c.(520-522)gCt>gTt	p.A174V		NM_022915.3	NP_075066.1	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44	174	RNase III.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGAAACTTGGCTGTGGAGCAG	0.483000													28	112					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15726582	15726582	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15726582C>T	ENST00000441682.2	+	0	219							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CGGTGTTTCCCGCAGCCCCGG	0.642000													8	118					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230471	140230471	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140230471G>A	ENST00000378122.3	+	1	3115	c.2391G>A	c.(2389-2391)ggG>ggA	p.G797G	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Silent_p.G797G|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCAACTGGGAAGGTGGGTT	0.423000													33	26					0	0	1	0	0
HBG2	3048	broad.mit.edu	37	11	5275566	5275566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5275566C>T	ENST00000380259.2	-	7	1511	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K	HBG2_ENST00000380252.1_Missense_Mutation_p.E81K|HBG2_ENST00000336906.4_Missense_Mutation_p.E91K					hemoglobin, gamma G											endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	13		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGTGCAGTTCACTCAGCTGG	0.507000													28	130					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19492695	19492695	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19492695C>T	ENST00000396229.2	+	15	3020	c.2271C>T	c.(2269-2271)atC>atT	p.I757I	TMC5_ENST00000219821.5_Silent_p.I511I|TMC5_ENST00000542583.2_Silent_p.I757I|CTA-363E6.6_ENST00000561762.1_RNA|TMC5_ENST00000541464.1_Silent_p.I705I|TMC5_ENST00000381414.4_Silent_p.I757I|TMC5_ENST00000561503.1_Silent_p.I398I|TMC5_ENST00000564959.1_Silent_p.I440I	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	757						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TTCACAGAATCATTGGGATGC	0.443000													12	89					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55761311	55761311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55761311G>A	ENST00000278409.1	-	1	790	c.791C>T	c.(790-792)tCc>tTc	p.S264F		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					GGAGTAGCTGGAACTAGGTCT	0.498000													32	81					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53190843	53190843	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:53190843T>G	ENST00000566029.1	+	2	1051	c.842T>G	c.(841-843)aTa>aGa	p.I281R	CHD9_ENST00000447540.1_Missense_Mutation_p.I281R|CHD9_ENST00000398510.3_Missense_Mutation_p.I281R|CHD9_ENST00000564845.1_Missense_Mutation_p.I281R			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	281	Ser-rich.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				AGTAATCATATATCACCAAAC	0.343000													36	78					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941152	144941152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144941152C>T	ENST00000525985.1	-	2	6341	c.6270G>A	c.(6268-6270)cgG>cgA	p.R2090R				P58107	EPIPL_HUMAN	epiplakin 1	2090						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTCGGAGTCCCGTGCAGCCT	0.597000													14	121					0	0	1	0	0
GCK	2645	broad.mit.edu	37	7	44189392	44189392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44189392C>T	ENST00000403799.3	-	6	1115	c.646G>A	c.(646-648)Gaa>Aaa	p.E216K	GCK_ENST00000345378.2_Missense_Mutation_p.E217K|GCK_ENST00000395796.3_Missense_Mutation_p.E215K|GCK_ENST00000437084.1_Missense_Mutation_p.E199K	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	216					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						TGATGGTCTTCGTAGTAGCAG	0.557000													40	81					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28761201	28761201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:28761201G>A	ENST00000422425.2	+	10	648	c.604G>A	c.(604-606)Ggc>Agc	p.G202S	PLB1_ENST00000327757.5_Missense_Mutation_p.G191S	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	191	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GCTTGCGGCGGGCGGCGTGGA	0.652000													13	21					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120148155	120148155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120148155G>A	ENST00000392521.2	-	39	5027	c.4972C>T	c.(4972-4974)Ctg>Ttg	p.L1658L	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Silent_p.L1616L	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1616	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		AAGACATTCAGGGCGTAGAGC	0.498000													44	66					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11728976	11728976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11728976G>A	ENST00000381486.2	+	10	1564	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	GREB1_ENST00000234142.5_Missense_Mutation_p.E422K|GREB1_ENST00000381483.2_Missense_Mutation_p.E422K	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	422						integral to membrane		p.E422K(2)		breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACGGGCATACGAGCAGTACGG	0.587000													43	88					0	0	1	0	0
RP11-909M7.3	0	broad.mit.edu	37	14	101450256	101450256	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101450256G>A	ENST00000554693.2	+	0	799				SNORD114-23_ENST00000363536.1_RNA																							CATAGACAATGAATACGTGTC	0.358000													62	197					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16339673	16339673	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:16339673G>A	ENST00000400202.1	-	3	1553	c.841C>T	c.(841-843)Cga>Tga	p.R281*	NRIP1_ENST00000318948.4_Nonsense_Mutation_p.R281*|NRIP1_ENST00000400199.1_Nonsense_Mutation_p.R281*			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	281	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GCGTGTTCTCGAGAATACTGC	0.458000													33	101					0	0	1	0	0
COMMD1	150684	broad.mit.edu	37	2	62132963	62132963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:62132963C>T	ENST00000311832.5	+	1	182	c.150C>T	c.(148-150)ccC>ccT	p.P50P	COMMD1_ENST00000538736.1_Silent_p.P50P|COMMD1_ENST00000472729.1_Intron	NM_152516.2	NP_689729.1	Q8N668	COMD1_HUMAN	copper metabolism (Murr1) domain containing 1	50					copper ion homeostasis|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process	cell junction|Cul2-RING ubiquitin ligase complex|cytoplasm|nucleolus	copper ion binding|protein homodimerization activity			large_intestine(1)|liver(2)|lung(5)|ovary(1)	9	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;4.73e-07)|Epithelial(17;0.0216)|all cancers(80;0.0934)			AGTTCCGCCCCTTTCTGGCAA	0.597000													12	48					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226570804	226570804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226570804G>A	ENST00000366794.5	-	8	1235	c.1092C>T	c.(1090-1092)tcC>tcT	p.S364S		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	364					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TGGCCGCCACGGAGGCGCTGG	0.512000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					85	280					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4881996	4881996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4881996G>A	ENST00000321919.9	-	5	597	c.521C>T	c.(520-522)cCc>cTc	p.P174L	GLYR1_ENST00000591451.1_Missense_Mutation_p.P174L|GLYR1_ENST00000436648.5_Intron|GLYR1_ENST00000586901.1_5'UTR|GLYR1_ENST00000381983.3_Missense_Mutation_p.P174L	NM_032569.3	NP_115958.2	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	174					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						ATCCTTTGGGGGCCGACCCCG	0.498000													19	47					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313882	54313882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54313882G>A	ENST00000324134.6	-	3	1199	c.1031C>T	c.(1030-1032)cCc>cTc	p.P344L	NLRP12_ENST00000354278.3_Missense_Mutation_p.P344L|NLRP12_ENST00000391772.1_Missense_Mutation_p.P344L|NLRP12_ENST00000351894.4_Missense_Mutation_p.P344L|NLRP12_ENST00000391775.3_Missense_Mutation_p.P344L|NLRP12_ENST00000535162.1_Missense_Mutation_p.P344L|NLRP12_ENST00000345770.5_Missense_Mutation_p.P344L|NLRP12_ENST00000391773.1_Missense_Mutation_p.P344L	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	344	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAAAGCCGTGGGCCGTGTGGT	0.547000													48	118					0	0	1	0	0
LARGE	9215	broad.mit.edu	37	22	34000534	34000534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:34000534G>A	ENST00000354992.2	-	6	1073	c.502C>T	c.(502-504)Ctg>Ttg	p.L168L	LARGE_ENST00000397394.2_Silent_p.L168L|LARGE_ENST00000402320.1_Silent_p.L168L|LARGE_ENST00000437602.2_Silent_p.L168L|LARGE_ENST00000337431.2_Silent_p.L168L	NM_004737.4	NP_004728.1	O95461	LARGE_HUMAN	like-glycosyltransferase	168					glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(1;0.219)				TGGAAGTGCAGAGGGTTCCGT	0.547000													18	62					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94888377	94888377	+	Missense_Mutation	SNP	G	G	A	rs139457907		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94888377G>A	ENST00000357742.4	+	7	989	c.989G>A	c.(988-990)cGa>cAa	p.R330Q	MCTP2_ENST00000543482.1_Missense_Mutation_p.R330Q|MCTP2_ENST00000451018.3_Missense_Mutation_p.R330Q|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	330					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AATCGGAAGCGATTAAGTGCC	0.318000													6	63					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43552380	43552380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43552380C>T	ENST00000220420.5	-	3	313	c.306G>A	c.(304-306)gtG>gtA	p.V102V	TGM5_ENST00000349114.4_Intron	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	102					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CGCACAAGCTCACCTCTGTGG	0.642000													28	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179638073	179638073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179638073G>A	ENST00000589042.1	-	33	7842	c.7618C>T	c.(7618-7620)Cgt>Tgt	p.R2540C	TTN_ENST00000342992.6_Missense_Mutation_p.R2540C|TTN_ENST00000360870.5_Missense_Mutation_p.R2540C|TTN_ENST00000591111.1_Missense_Mutation_p.R2540C|TTN_ENST00000342175.6_Missense_Mutation_p.R2494C|TTN_ENST00000359218.5_Missense_Mutation_p.R2494C|TTN-AS1_ENST00000584485.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R2494C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2274							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R2494C(3)|p.R2540C(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAAGGTCACGAAGACCTCTG	0.353000													22	68					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958448	53958448	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53958448C>T	ENST00000454407.1	+	0	1140							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		ACAGCTCACTCTTAAGGAAAC	0.363000													46	169					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69329483	69329483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:69329483C>T	ENST00000260364.5	+	9	1551	c.1250C>T	c.(1249-1251)gCc>gTc	p.A417V	NOX5_ENST00000448182.3_Missense_Mutation_p.A389V|NOX5_ENST00000530406.2_Missense_Mutation_p.A407V|NOX5_ENST00000455873.3_Missense_Mutation_p.A400V|NOX5_ENST00000388866.3_Missense_Mutation_p.A435V			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	435	Ferric oxidoreductase.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CTGGAGAAGGCCATCGGACTG	0.572000													36	98					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13830851	13830851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13830851C>T	ENST00000265104.4	-	36	6020	c.5916G>A	c.(5914-5916)atG>atA	p.M1972I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1972	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCCCCATGCTCATTCCCAGAG	0.512000									Kartagener syndrome				32	74					0	0	1	0	0
NEURL3	93082	broad.mit.edu	37	2	97171064	97171064	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97171064G>A	ENST00000310865.3	-	0	18									neuralized E3 ubiquitin protein ligase 3																		GGTCTAGAAGGAACTGCCTGG	0.522000													14	41					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720829	140720829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140720829G>A	ENST00000394576.2	+	1	2291	c.2291G>A	c.(2290-2292)cGg>cAg	p.R764Q	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGACTCGCGGAAGAGCCAC	0.562000													22	216					0	0	1	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420206	56420206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:56420206G>A	ENST00000407595.2	+	2	1373	c.871G>A	c.(871-873)Gaa>Aaa	p.E291K	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	291	His-rich.									breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGGCAGCCCCGAACAGCAAAG	0.627000													46	114					0	0	1	0	0
TTC39A	22996	broad.mit.edu	37	1	51777827	51777827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:51777827G>A	ENST00000262676.5	-	4	470	c.310C>T	c.(310-312)Ctg>Ttg	p.L104L	TTC39A_ENST00000451380.1_Silent_p.L107L|TTC39A_ENST00000447632.2_Silent_p.L108L|TTC39A_ENST00000371750.5_Silent_p.L108L|TTC39A_ENST00000371747.3_Silent_p.L107L|TTC39A_ENST00000262675.7_Silent_p.L80L|TTC39A_ENST00000413473.2_Silent_p.L111L			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	108							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						CGGTTCACCAGGCTGCTGAAG	0.567000													4	18					0	0	1	0	0
GSG1L	146395	broad.mit.edu	37	16	27895874	27895874	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27895874G>A	ENST00000380898.2	-	3	567	c.18C>T	c.(16-18)ttC>ttT	p.F6F	GSG1L_ENST00000380897.3_Silent_p.F6F|GSG1L_ENST00000569166.1_Silent_p.F6F|GSG1L_ENST00000447459.2_Silent_p.F161F|GSG1L_ENST00000395724.3_Intron			Q6UXU4	GSG1L_HUMAN	GSG1-like	161						integral to membrane				endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(4)	17						TGCTGGAGTGGAAGAGCTCGA	0.587000													4	14					0	0	1	0	0
ODAM	54959	broad.mit.edu	37	4	71063013	71063013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71063013G>A	ENST00000396094.2	+	3	164	c.116G>A	c.(115-117)gGt>gAt	p.G39D		NM_017855.3	NP_060325.3	A1E959	ODAM_HUMAN	odontogenic, ameloblast asssociated	39					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(3)|skin(2)	20						CTTAATAATGGTCAACTTTTG	0.274000													24	89					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131072886	131072886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131072886G>A	ENST00000357668.1	-	27	3158	c.3131C>T	c.(3130-3132)tCc>tTc	p.S1044F	ASAP1_ENST00000518721.1_Missense_Mutation_p.S1044F			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	1044					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						GAGGTCGTTGGAGTCTTCAGA	0.532000													26	199					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10363559	10363559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10363559C>T	ENST00000377093.4	+	21	2469	c.2316C>T	c.(2314-2316)gcC>gcT	p.A772A	KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000377083.1_Silent_p.A772A	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AGCTTTGTGCCATGTATGGCA	0.537000													45	81					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142188379	142188379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142188379C>T	ENST00000350721.4	-	38	6473	c.6352G>A	c.(6352-6354)Gat>Aat	p.D2118N	ATR_ENST00000383101.3_Missense_Mutation_p.D2054N|RP11-383G6.3_ENST00000460977.1_RNA	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2118	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TTACCCAAATCATTCCTCATT	0.343000								Other conserved DNA damage response genes					31	83					0	0	1	0	0
TPM3	7170	broad.mit.edu	37	1	154163758	154163758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154163758C>T	ENST00000368530.2	-	2	339	c.147G>A	c.(145-147)aaG>aaA	p.K49K	TPM3_ENST00000271850.7_Silent_p.K49K	NM_152263.2	NP_689476.2	P06753	TPM3_HUMAN	tropomyosin 3	48					cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/NTRK1_ENST00000392302(70)|TPM3/ALK(33)	breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					CTTTCAGCTTCTTCTGCATGG	0.512000			T	"""NTRK1, ALK, ROS1"""	"""papillary thyroid, ALCL, NSCLC"""								40	76					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806039	54806039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54806039C>T	ENST00000306858.7	+	5	2386	c.2270C>T	c.(2269-2271)tCa>tTa	p.S757L		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	757										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					GAACTTGCTTCAAAGAAGGAA	0.383000													16	57					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58512243	58512243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58512243G>A	ENST00000302819.5	-	10	1587	c.1296C>T	c.(1294-1296)gcC>gcT	p.A432A	ACOX2_ENST00000459701.2_Silent_p.A418A	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	432					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		AGGTACAGGAGGCCGACAATT	0.607000													22	29					0	0	1	0	0
GPR162	27239	broad.mit.edu	37	12	6936037	6936037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6936037C>T	ENST00000311268.3	+	5	2222	c.1435C>T	c.(1435-1437)Ctt>Ttt	p.L479F	GPR162_ENST00000382315.3_Missense_Mutation_p.L175F|GPR162_ENST00000428545.2_Missense_Mutation_p.L195F	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	479						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						GCTGGCCAGCCTTCGCCAATT	0.642000													28	118					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	12006381	12006381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:12006381C>T	ENST00000396373.4	+	4	623	c.349C>T	c.(349-351)Ctt>Ttt	p.L117F		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	117	PNT.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CTATGAACTCCTTCAGCATAT	0.443000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								45	113					0	0	1	0	0
C4orf45	152940	broad.mit.edu	37	4	159836479	159836479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:159836479C>T	ENST00000434826.2	-	4	473	c.389G>A	c.(388-390)gGa>gAa	p.G130E	C4orf45_ENST00000508011.1_5'UTR	NM_152543.2	NP_689756.2	Q96LM5	CD045_HUMAN	chromosome 4 open reading frame 45	130										large_intestine(2)|lung(3)	5						ACTCTGTTTTCCTTGCATATC	0.433000													8	22					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26718782	26718782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26718782G>A	ENST00000396005.3	-	8	1278	c.969C>T	c.(967-969)gtC>gtT	p.V323V	SLC5A12_ENST00000280467.6_Silent_p.V323V	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	323					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						ATATCTCCATGACAAAGTACG	0.378000													40	81					0	0	1	0	0
RBBP5	5929	broad.mit.edu	37	1	205069166	205069166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205069166G>A	ENST00000264515.6	-	8	920	c.779C>T	c.(778-780)tCt>tTt	p.S260F	RBBP5_ENST00000367164.1_Missense_Mutation_p.S260F	NM_001193273.1|NM_005057.3	NP_001180202.1|NP_005048.2	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	260					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CCCATCCCCAGAGAAACAACA	0.507000													25	75					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999578	46999578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46999578C>T	ENST00000374314.4	+	1	1653	c.698C>T	c.(697-699)gCt>gTt	p.A233V	GPRIN2_ENST00000374317.1_Missense_Mutation_p.A233V			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	233			A -> S (in dbSNP:rs11204659).							breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						CCCCCAGCTGCTCTACTCTGT	0.632000													5	48					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171227237	171227237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171227237G>A	ENST00000354841.4	+	1	142	c.11G>A	c.(10-12)cGa>cAa	p.R4Q	FMO1_ENST00000402921.2_Missense_Mutation_p.R4Q|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.R4Q			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	4					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGGCCAAGCGAGTTGCCATT	0.537000													21	52					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	240976925	240976925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240976925C>T	ENST00000366565.1	-	13	1330	c.949G>A	c.(949-951)Gag>Aag	p.E317K	RGS7_ENST00000366563.1_Missense_Mutation_p.E317K|RGS7_ENST00000446183.2_Missense_Mutation_p.E233K|RGS7_ENST00000366562.4_Missense_Mutation_p.E317K|RGS7_ENST00000401882.1_Missense_Mutation_p.E264K|RGS7_ENST00000331110.7_Missense_Mutation_p.E291K|RGS7_ENST00000348120.2_Missense_Mutation_p.E264K|RGS7_ENST00000366564.1_Missense_Mutation_p.E317K|RGS7_ENST00000407727.1_Missense_Mutation_p.E317K	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	317					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TACCTTGCCTCAAGTTCCCAG	0.433000													15	35					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184298852	184298852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184298852G>A	ENST00000330394.2	+	14	3083	c.2631G>A	c.(2629-2631)cgG>cgA	p.R877R	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	877	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCTGGGTGCGGGACCGGAACC	0.602000													28	86					0	0	1	0	0
NOX1	27035	broad.mit.edu	37	X	100117458	100117458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:100117458C>T	ENST00000372966.3	-	6	799	c.594G>A	c.(592-594)agG>agA	p.R198R	NOX1_ENST00000372960.4_Silent_p.R161R|NOX1_ENST00000372964.1_Intron|NOX1_ENST00000217885.5_Silent_p.R198R	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	198	Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						CAAAATAACTCCTCCGGATGA	0.438000													114	68					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70387219	70387219	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70387219C>T	ENST00000374051.3	+	6	1534	c.1212C>T	c.(1210-1212)gtC>gtT	p.V404V	NLGN3_ENST00000536169.1_Silent_p.V384V|NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000358741.3_Silent_p.V424V	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	424					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					AGGATGGTGTCTCTGGCACTG	0.517000													31	20					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79387439	79387439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79387439C>T	ENST00000264895.6	+	50	7547	c.7107C>T	c.(7105-7107)ttC>ttT	p.F2369F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2368					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GGCAGCATTTCCACCTCACCT	0.557000													22	74					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971644	96971644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96971644G>A	ENST00000341686.3	+	6	890	c.765G>A	c.(763-765)atG>atA	p.M255I	C10orf129_ENST00000394005.3_Missense_Mutation_p.M255I|C10orf129_ENST00000430183.1_Missense_Mutation_p.M100I	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	255					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GACGGTGGATGGATCTCCAGC	0.483000													12	42					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101510475	101510475	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101510475G>A	ENST00000392979.3	+	24	2725	c.2364G>A	c.(2362-2364)gtG>gtA	p.V788V	ANO4_ENST00000392977.3_Silent_p.V823V|ANO4_ENST00000550015.1_Silent_p.V343V|ANO4_ENST00000299222.9_Silent_p.V343V	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	823						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TTGGCTATGTGAATGCCAGCT	0.473000										HNSCC(74;0.22)			79	207					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60591609	60591609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:60591609C>T	ENST00000406854.1	+	9	3274	c.2720C>T	c.(2719-2721)tCt>tTt	p.S907F	PCNXL4_ENST00000535349.1_Missense_Mutation_p.S114F|PCNXL4_ENST00000404681.2_Missense_Mutation_p.S907F|PCNXL4_ENST00000317623.4_Missense_Mutation_p.S673F|PCNXL4_ENST00000406949.1_Missense_Mutation_p.S673F					pecanex-like 4 (Drosophila)																		TGTTCACATTCTCACTTAGTA	0.423000													11	167					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882500	228882500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228882500C>T	ENST00000392056.3	-	7	3116	c.3070G>A	c.(3070-3072)Gag>Aag	p.E1024K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E1024K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1024						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCATGGACTCATCCACAACC	0.498000													30	120					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159171	152159171	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:152159171G>A	ENST00000439251.1	-	2	1410	c.972C>T	c.(970-972)ctC>ctT	p.L324L	PNMA5_ENST00000535214.1_Silent_p.L324L|PNMA5_ENST00000452693.1_Silent_p.L324L|PNMA5_ENST00000361887.5_Silent_p.L324L	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	324					apoptosis			p.L324L(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					CATCTCGAATGAGCTTCATTA	0.562000													23	26					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78071191	78071191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78071191C>T	ENST00000397545.4	+	19	3196	c.3169C>T	c.(3169-3171)Ctc>Ttc	p.L1057F		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1057					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTTGGGGCCCTCAAACGACA	0.592000													10	39					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44234833	44234833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:44234833G>A	ENST00000330884.4	-	4	542	c.422C>T	c.(421-423)tCt>tTt	p.S141F	SULT4A1_ENST00000249130.5_Missense_Mutation_p.S141F|SULT4A1_ENST00000540422.1_Intron	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	141					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		CTGATAATAAGACACCACCAG	0.552000													21	59					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25014056	25014056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25014056C>T	ENST00000382114.4	-	7	906	c.721G>A	c.(721-723)Gat>Aat	p.D241N		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	241						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				ACGTACACATCGTTCTTGGAG	0.468000													26	84					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17190305	17190305	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17190305A>G	ENST00000265970.7	-	1	983	c.984T>C	c.(982-984)ctT>ctC	p.L328L	PIK3C2A_ENST00000531428.1_Intron|PIK3C2A_ENST00000540361.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	328					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	TTGCCACAGAAAGGGATTTTC	0.398000													32	163					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8590392	8590392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8590392G>A	ENST00000338257.8	-	25	3092	c.2825C>T	c.(2824-2826)cCt>cTt	p.P942L		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	942						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CGCCCGGGTAGGGGCTTGGGA	0.607000													29	43					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2855543	2855543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2855543G>A	ENST00000520002.1	-	55	8925	c.8370C>T	c.(8368-8370)ccC>ccT	p.P2790P	CSMD1_ENST00000542608.1_Silent_p.P2731P|CSMD1_ENST00000400186.3_Silent_p.P2732P|CSMD1_ENST00000602557.1_Silent_p.P2790P|CSMD1_ENST00000537824.1_Silent_p.P2789P|CSMD1_ENST00000602723.1_Silent_p.P2732P			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2790	Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCGACACGTGGGCAGAGGGC	0.547000													9	29					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237604620	237604620	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237604620A>G	ENST00000366574.2	+	13	1324	c.1005_splice	c.e13-1	p.E336_splice	RYR2_ENST00000542537.1_Splice_Site_p.E320_splice|RYR2_ENST00000360064.6_Splice_Site_p.E334_splice	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	336	MIR 4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCCCCTTAGGAAAAATTGGAT	0.358000													24	55					0	0	1	0	0
TMCO4	255104	broad.mit.edu	37	1	20107106	20107106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:20107106G>A	ENST00000294543.6	-	4	387	c.146C>T	c.(145-147)tCc>tTc	p.S49F	TMCO4_ENST00000375122.2_Missense_Mutation_p.S49F|TMCO4_ENST00000375127.1_Missense_Mutation_p.S49F	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	49						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		CTGGGACAGGGAGATGCCACA	0.592000													15	33					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12856867	12856867	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12856867G>A	ENST00000456430.2	+	8	1275	c.1234G>A	c.(1234-1236)Gga>Aga	p.G412R	CAND2_ENST00000295989.5_Missense_Mutation_p.G319R	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	412					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GCCCCCGAAGGGATGGCTGGA	0.612000													23	62					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89265995	89265995	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89265995C>T	ENST00000464162.1	-	0	165																											CTGACTTGCCCGGCAAGTGAT	0.502000													59	202					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103142729	103142729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103142729G>A	ENST00000295269.4	+	11	2419	c.1962G>A	c.(1960-1962)aaG>aaA	p.K654K		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	654					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CTGGCACCAAGAATATCCGCT	0.517000													41	114					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131519662	131519662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131519662G>A	ENST00000423981.1	+	2	127	c.17G>A	c.(16-18)gGa>gAa	p.G6E	AMER3_ENST00000321420.4_Missense_Mutation_p.G6E	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		CTGAAGAGAGGAAAGACCTTC	0.622000													3	16					0	0	1	0	0
CIDEA	1149	broad.mit.edu	37	18	12277269	12277269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:12277269G>A	ENST00000320477.9	+	5	725	c.660G>A	c.(658-660)taG>taA	p.*220*	CIDEA_ENST00000521296.1_3'UTR	NM_001279.3	NP_001270.1	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a	0					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)	13						CGTGTGGATAGGGATGCAGGC	0.527000													25	29					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75514208	75514208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75514208G>A	ENST00000355774.2	-	2	2366	c.2151C>T	c.(2149-2151)ttC>ttT	p.F717F	MLH3_ENST00000556740.1_Silent_p.F717F|MLH3_ENST00000238662.7_Silent_p.F717F|MLH3_ENST00000556257.1_Silent_p.F717F|MLH3_ENST00000380968.2_5'UTR	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	717					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TATACCAGGGGAAAGAGGGGG	0.378000								Mismatch excision repair (MMR)					39	99					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143986231	143986231	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:143986231C>T	ENST00000409869.1	+	6	555	c.378C>T	c.(376-378)tcC>tcT	p.S126S	ARHGAP15_ENST00000295095.6_Silent_p.S126S			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	126	PH.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		AGGCTCTGTCCAATATGGTAA	0.303000													34	58					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413680	178413680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178413680C>T	ENST00000231188.5	-	8	1753	c.1575G>A	c.(1573-1575)ggG>ggA	p.G525G	GRM6_ENST00000517717.1_Silent_p.G525G|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	525					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TCTTCCGCTCCCCCGGCCCGC	0.672000													13	46					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846459	43846459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43846459C>T	ENST00000389420.3	-	13	1799	c.1800G>A	c.(1798-1800)atG>atA	p.M600I	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.M600I	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	600	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ATCGAAATTTCATCCTGCGGC	0.388000													10	17					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176738894	176738894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176738894C>T	ENST00000367662.3	+	16	5639	c.4475C>T	c.(4474-4476)tCt>tTt	p.S1492F		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1492	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGCTCAATCTCTTGTGTCCCA	0.522000													52	106					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19317917	19317917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:19317917C>T	ENST00000461366.1	+	9	1167	c.952C>T	c.(952-954)Cgt>Tgt	p.R318C		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	318							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						CCTCTTAGTTCGTGACTCATC	0.597000													19	26					0	0	1	0	0
HFE2	148738	broad.mit.edu	37	1	145415657	145415657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145415657G>A	ENST00000336751.5	+	3	714	c.476G>A	c.(475-477)gGt>gAt	p.G159D	HFE2_ENST00000475797.1_Intron|HFE2_ENST00000497365.1_Intron|HFE2_ENST00000357836.5_Missense_Mutation_p.G46D	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	159					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGGCTGCATGGTCGTCCCCCG	0.687000													14	46					0	0	1	0	0
IL12B	3593	broad.mit.edu	37	5	158745790	158745790	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:158745790G>A	ENST00000231228.2	-	6	1264	c.809C>T	c.(808-810)tCc>tTc	p.S270F		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	270	Fibronectin type-III.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAATGTCAGGGAGAAGTAGGA	0.507000													26	62					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350440	30350440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30350440C>T	ENST00000359358.4	-	2	553	c.115G>A	c.(115-117)Gcc>Acc	p.A39T	KLHL14_ENST00000358095.4_Missense_Mutation_p.A39T|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	39	BTB.					cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						TGGCCCTGGGCCGTCAGGGTC	0.652000													8	60					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411082	126411082	+	Missense_Mutation	SNP	A	A	T	rs139260545	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126411082A>T	ENST00000394329.3	+	17	13118	c.13105A>T	c.(13105-13107)Atg>Ttg	p.M4369L	FAT4_ENST00000335110.5_Missense_Mutation_p.M2610L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4369	Laminin G-like 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CATTGCTTCTATGTGGTATGG	0.438000													65	172					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182026719	182026719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:182026719C>T	ENST00000339948.3	-	2	634	c.427G>A	c.(427-429)Gac>Aac	p.D143N		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						GGTAGTCGGTCCCCAAGAGGT	0.572000													25	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179644778	179644778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179644778C>T	ENST00000589042.1	-	22	3902	c.3678G>A	c.(3676-3678)agG>agA	p.R1226R	TTN_ENST00000342992.6_Silent_p.R1226R|TTN_ENST00000360870.5_Silent_p.R1226R|TTN_ENST00000591111.1_Silent_p.R1226R|TTN_ENST00000342175.6_Silent_p.R1180R|TTN_ENST00000359218.5_Silent_p.R1180R|TTN_ENST00000460472.2_Silent_p.R1180R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1226							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATTTTCTTCCTAATTAAGG	0.333000													36	64					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254404	30254404	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:30254404C>T	ENST00000361644.2	+	5	1100	c.363C>T	c.(361-363)ttC>ttT	p.F121F	MAGEB3_ENST00000378986.1_Silent_p.F121F	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	121	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						TGGTGCAGTTCCTGATGGAAA	0.393000													20	19					0	0	1	0	0
KCNE1	3753	broad.mit.edu	37	21	35821901	35821901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:35821901G>A	ENST00000337385.3	-	3	407	c.32C>T	c.(31-33)cCc>cTc	p.P11L	KCNE1_ENST00000399286.2_Missense_Mutation_p.P11L|KCNE1_ENST00000399289.3_Missense_Mutation_p.P11L|KCNE1_ENST00000432085.1_Missense_Mutation_p.P11L|KCNE1_ENST00000416357.2_Missense_Mutation_p.P11L|KCNE1_ENST00000399284.1_Missense_Mutation_p.P11L	NM_001270402.1|NM_001270403.1	NP_001257331.1|NP_001257332.1	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related family, member 1	11					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound	lysosome	delayed rectifier potassium channel activity|potassium channel regulator activity			large_intestine(4)|lung(1)|ovary(2)	7					Indapamide(DB00808)	GGTCAGAAAGGGCGTCACCGC	0.587000													13	39					0	0	1	0	0
APOC4-APOC2	100533990	broad.mit.edu	37	19	45448094	45448094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45448094G>A	ENST00000419266.2	+	2	205	c.165G>A	c.(163-165)aaG>aaA	p.K55K	APOC4-APOC2_ENST00000436871.1_Silent_p.K55K|APOC4_ENST00000592954.1_Silent_p.K55K|APOC4-APOC2_ENST00000589057.1_Silent_p.K55K|APOC4_ENST00000591600.1_Silent_p.K55K																							GCAGGATGAAGGAGCTGCTGG	0.622000													10	6					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30531273	30531273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30531273C>T	ENST00000356798.6	+	30	3504	c.3324C>T	c.(3322-3324)ttC>ttT	p.F1108F	ITGAL_ENST00000358164.5_Silent_p.F1024F|ITGAL_ENST00000433423.2_Silent_p.F342F	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1108					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TGCTCATTTTCATAGTGCTGT	0.587000													14	112					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20328687	20328687	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20328687G>A	ENST00000302555.5	-	8	1413	c.1264C>T	c.(1264-1266)Caa>Taa	p.Q422*	GP2_ENST00000341642.5_Nonsense_Mutation_p.Q275*|GP2_ENST00000381360.5_Nonsense_Mutation_p.Q278*|GP2_ENST00000381362.4_Nonsense_Mutation_p.Q425*			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	425	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GAATCACGTTGATTTGAGCAG	0.478000													14	68					0	0	1	0	0
CD28	940	broad.mit.edu	37	2	204591684	204591684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:204591684G>A	ENST00000374481.3	+	3	351	c.129G>A	c.(127-129)aaG>aaA	p.K43K	CD28_ENST00000324106.7_Silent_p.K127K|CD28_ENST00000374478.4_Intron|CD28_ENST00000458610.2_Silent_p.K141K			P10747	CD28_HUMAN	CD28 molecule	127	Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						ACAATGAGAAGAGCAATGGAA	0.373000													15	72					0	0	1	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679361	37679361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:37679361G>A	ENST00000379800.3	-	1	442	c.33C>T	c.(31-33)ctC>ctT	p.L11L		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	11					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		CTCCCACAACGAGTTCGGCTT	0.592000													41	92					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35949969	35949969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35949969G>A	ENST00000490799.1	-	8	1307	c.954C>T	c.(952-954)ttC>ttT	p.F318F	SLC26A8_ENST00000394602.2_Silent_p.F213F|SLC26A8_ENST00000355574.2_Silent_p.F318F	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	318					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						CAATCACAGTGAAGCCAATAA	0.418000													37	86					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103400011	103400011	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103400011A>T	ENST00000358392.2	-	46	3947	c.3630T>A	c.(3628-3630)ggT>ggA	p.G1210G	COL11A1_ENST00000512756.1_Silent_p.G1082G|COL11A1_ENST00000353414.4_Silent_p.G1159G|COL11A1_ENST00000370096.3_Silent_p.G1198G	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1198	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTACCTGAAGACCTATTGGAC	0.453000													15	66					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833838	168833838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168833838C>T	ENST00000464456.1	-	7	2458	c.1258G>A	c.(1258-1260)Gat>Aat	p.D420N	MECOM_ENST00000433243.2_Missense_Mutation_p.D421N|MECOM_ENST00000472280.1_Missense_Mutation_p.D421N|MECOM_ENST00000392736.3_Missense_Mutation_p.D420N|MECOM_ENST00000494292.1_Missense_Mutation_p.D608N|MECOM_ENST00000468789.1_Missense_Mutation_p.D420N|MECOM_ENST00000264674.3_Missense_Mutation_p.D485N|MECOM_ENST00000460814.1_Missense_Mutation_p.D420N	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TTCTCTTTATCACTTTCAATG	0.383000													17	76					0	0	1	0	0
TDP1	55775	broad.mit.edu	37	14	90450874	90450874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90450874C>T	ENST00000335725.4	+	9	1149	c.899C>T	c.(898-900)cCc>cTc	p.P300L	TDP1_ENST00000555880.1_Missense_Mutation_p.P300L|TDP1_ENST00000393454.2_Missense_Mutation_p.P300L|TDP1_ENST00000393452.3_Missense_Mutation_p.P300L|TDP1_ENST00000357382.3_Missense_Mutation_p.P61L	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	300					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGTTGAGCCCCTTATACCCA	0.393000								Repair of DNA-protein crosslinks					50	211					0	0	1	0	0
CYP51A1	1595	broad.mit.edu	37	7	91753076	91753076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:91753076G>A	ENST00000003100.8	-	6	1027	c.862C>T	c.(862-864)Ctc>Ttc	p.L288F	LRRD1_ENST00000422722.1_5'UTR|CYP51A1_ENST00000450723.1_Missense_Mutation_p.L183F	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	282					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	AAAGTTTGGAGAATGTCATCA	0.343000													9	73					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43585109	43585109	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43585109G>A	ENST00000452443.2	-	3	241	c.237C>T	c.(235-237)ttC>ttT	p.F79F		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	79					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CCCGGGTGAGGAAGAATGTGG	0.527000													59	190					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237617862	237617862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237617862C>T	ENST00000366574.2	+	15	1781	c.1464C>T	c.(1462-1464)ctC>ctT	p.L488L	RYR2_ENST00000542537.1_Silent_p.L472L|RYR2_ENST00000360064.6_Silent_p.L486L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	488					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCAAAATCTCTTCCAGGAAG	0.428000													4	16					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170952658	170952658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:170952658G>A	ENST00000367759.4	+	9	866	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K	MROH9_ENST00000367758.3_Missense_Mutation_p.E238K	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		TCAACAAGACGAAAGTAAAAT	0.358000													7	39					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58453672	58453672	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58453672G>A	ENST00000282308.3	-	3	700	c.504C>T	c.(502-504)ttC>ttT	p.F168F	ZNF256_ENST00000598928.1_3'UTR	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	168					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		CCTTGCAAGTGAAGGGCTTCC	0.478000													10	108					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	170159870	170159870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:170159870G>A	ENST00000328939.4	+	6	1039	c.502G>A	c.(502-504)Gag>Aag	p.E168K	KCNIP1_ENST00000434108.1_Missense_Mutation_p.E193K|KCNIP1_ENST00000390656.4_Missense_Mutation_p.E168K|KCNIP1_ENST00000520740.1_Missense_Mutation_p.E140K|KCNIP1_ENST00000377360.4_Missense_Mutation_p.E177K|KCNIP1_ENST00000411494.1_Missense_Mutation_p.E179K	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	179	EF-hand 3.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTGCTCAAAGAGGACACTCC	0.498000													21	59					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91169122	91169122	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91169122C>T	ENST00000420329.2	+	10	1011	c.864C>T	c.(862-864)gcC>gcT	p.A288A	RP11-387D10.2_ENST00000559531.1_RNA|CRTC3_ENST00000268184.6_Silent_p.A288A	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	288					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CCCTGCCAGCCTCCCTGGACA	0.542000			T	MAML2	salivary gland mucoepidermoid								72	532					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74208526	74208526	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74208526C>T	ENST00000269391.6	-	2	258	c.126G>A	c.(124-126)gaG>gaA	p.E42E	RNF157_ENST00000592271.1_Silent_p.E42E|RNF157_ENST00000319945.6_Silent_p.E42E	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	42							zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			AGTCAAACTTCTCTCCTCCCA	0.403000													8	83					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999077	46999077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46999077G>A	ENST00000374314.4	+	1	1152	c.197G>A	c.(196-198)gGg>gAg	p.G66E	GPRIN2_ENST00000374317.1_Missense_Mutation_p.G66E			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	66										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GAGGAAGAGGGGAACCCGCCT	0.692000													11	80					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66879961	66879961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66879961C>T	ENST00000269080.2	-	27	3695	c.3558G>A	c.(3556-3558)aaG>aaA	p.K1186K	ABCA8_ENST00000586539.1_Silent_p.K1226K|ABCA8_ENST00000430352.2_Silent_p.K1226K	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1186						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TCATTGATTTCTTTCCAAACT	0.284000													13	36					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383124	108383124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108383124C>T	ENST00000265843.4	-	6	3220	c.3110G>A	c.(3109-3111)gGa>gAa	p.G1037E	EXPH5_ENST00000428840.1_Missense_Mutation_p.G961E|EXPH5_ENST00000443411.1_Missense_Mutation_p.G849E|EXPH5_ENST00000525344.1_Missense_Mutation_p.G1030E	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1037					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TATTTTACTTCCTGACTGCCT	0.373000													29	68					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50055509	50055509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50055509G>A	ENST00000281631.5	+	4	375	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	PARP8_ENST00000511363.2_Intron|PARP8_ENST00000505554.1_Missense_Mutation_p.E52K|PARP8_ENST00000503750.2_Missense_Mutation_p.E73K|PARP8_ENST00000514342.2_5'UTR|PARP8_ENST00000505697.2_Missense_Mutation_p.E73K|PARP8_ENST00000514067.2_Missense_Mutation_p.E73K	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	73						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				AGAGAATGATGAAGATGTGCT	0.244000													16	85					0	0	1	0	0
CD79A	973	broad.mit.edu	37	19	42383213	42383213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42383213C>T	ENST00000221972.3	+	2	418	c.233C>T	c.(232-234)cCt>cTt	p.P78L	CD79A_ENST00000444740.2_Missense_Mutation_p.P78L	NM_001783.3|NM_021601.3	NP_001774.1|NP_067612.1	P11912	CD79A_HUMAN	CD79a molecule, immunoglobulin-associated alpha	78	Ig-like C2-type.				B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11						ACGTGGCCCCCTGAGTTCTTG	0.617000			"""O, S"""		DLBCL								29	77					0	0	1	0	0
CKMT2	1160	broad.mit.edu	37	5	80555016	80555016	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:80555016G>A	ENST00000424301.2	+	9	1195	c.957G>A	c.(955-957)tcG>tcA	p.S319S	CTC-281B15.1_ENST00000500148.2_RNA|CTC-281B15.1_ENST00000501927.2_RNA|CKMT2_ENST00000254035.4_Silent_p.S319S|CTC-281B15.1_ENST00000511495.1_RNA|CTC-281B15.1_ENST00000502041.2_RNA|CTC-281B15.1_ENST00000505295.1_RNA|CKMT2_ENST00000437669.1_Silent_p.S319S|CTC-281B15.1_ENST00000503483.2_RNA|CTC-281B15.1_ENST00000512287.1_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	319	Phosphagen kinase C-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	CCTGTCCTTCGAACCTTGGAA	0.512000													12	142					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285448	48285448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48285448C>T	ENST00000320048.1	+	1	36	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						AAATAATTTTCGTGGGATTTT	0.428000													26	30					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83711968	83711968	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:83711968C>T	ENST00000566620.1	+	10	1730	c.1440C>T	c.(1438-1440)gaC>gaT	p.D480D	CDH13_ENST00000428848.3_Silent_p.D441D|CDH13_ENST00000268613.10_Silent_p.D527D	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	480	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TCTACCCAGACCCCATGATGG	0.612000													9	55					0	0	1	0	0
MAN1C1	57134	broad.mit.edu	37	1	26104708	26104708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26104708G>A	ENST00000374332.4	+	9	1700	c.1370G>A	c.(1369-1371)gGc>gAc	p.G457D	MAN1C1_ENST00000263979.3_Missense_Mutation_p.G277D|MAN1C1_ENST00000374329.1_Missense_Mutation_p.G228D	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	457					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		TTCTCCGGGGGCATGATCGCC	0.612000													21	44					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39987429	39987429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:39987429C>T	ENST00000373257.3	+	20	2570	c.2479C>T	c.(2479-2481)Ctg>Ttg	p.L827L	LPIN3_ENST00000491528.1_3'UTR	NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	827					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				CAGCACAGACCTGGCCAACCC	0.617000													12	135					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150266998	150266998	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150266998C>T	ENST00000255945.2	+	2	184	c.9C>T	c.(7-9)gcC>gcT	p.A3A	GIMAP4_ENST00000494750.1_Intron|GIMAP4_ENST00000461940.1_Silent_p.A3A	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	3							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAATGGCAGCCCAATACGGCA	0.512000													17	58					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152847233	152847233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152847233G>A	ENST00000367255.5	-	5	808	c.207C>T	c.(205-207)gtC>gtT	p.V69V	SYNE1_ENST00000466159.2_Silent_p.V69V|SYNE1_ENST00000413186.2_Silent_p.V69V|SYNE1_ENST00000448038.1_Silent_p.V69V|SYNE1_ENST00000367253.4_Silent_p.V69V|SYNE1_ENST00000367248.3_Silent_p.V69V|SYNE1_ENST00000423061.1_Silent_p.V69V|SYNE1_ENST00000265368.4_Silent_p.V69V|SYNE1_ENST00000341594.5_Silent_p.V69V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	69	Actin-binding.|CH 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCCCAGACAGGACCTCCAGAA	0.413000										HNSCC(10;0.0054)			6	78					0	0	1	0	0
PLAU	5328	broad.mit.edu	37	10	75673453	75673453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75673453C>T	ENST00000446342.1	+	6	1048	c.566C>T	c.(565-567)aCc>aTc	p.T189I	PLAU_ENST00000372762.4_Missense_Mutation_p.T170I|PLAU_ENST00000494287.1_3'UTR|PLAU_ENST00000372764.3_Missense_Mutation_p.T206I|C10orf55_ENST00000412307.2_Intron|C10orf55_ENST00000409178.1_Intron	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	206	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	GGCTCTGTCACCTACGTGTGT	0.592000													32	98					0	0	1	0	0
TNRC6C	57690	broad.mit.edu	37	17	76098601	76098601	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76098601C>T	ENST00000335749.4	+	19	5225	c.4656C>T	c.(4654-4656)ctC>ctT	p.L1552L	TNRC6C_ENST00000588847.1_Silent_p.L1552L|TNRC6C_ENST00000588061.1_Silent_p.L1516L|TNRC6C_ENST00000541771.1_Silent_p.L1516L|TNRC6C_ENST00000544502.1_Silent_p.L1552L|TNRC6C_ENST00000301624.4_Silent_p.L1516L	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	1516	Sufficient for translational repression when tethered to a target mRNA.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GCAGCTGGCTCGTTCTTCGAA	0.592000													6	17					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110477426	110477426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110477426C>T	ENST00000378402.5	+	49	8469	c.8365C>T	c.(8365-8367)Cgc>Tgc	p.R2789C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2789					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGCTGGCTTTCGCTGGGAACA	0.393000										HNSCC(38;0.096)			27	49					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56917978	56917978	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56917978C>T	ENST00000438926.2	+	14	1716	c.1687C>T	c.(1687-1689)Caa>Taa	p.Q563*	SLC12A3_ENST00000566786.1_Nonsense_Mutation_p.Q562*|SLC12A3_ENST00000262502.5_Nonsense_Mutation_p.Q562*|SLC12A3_ENST00000563236.1_Nonsense_Mutation_p.Q563*	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	563					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	ACCTTCATTCCAATACTACAA	0.612000													12	49					0	0	1	0	0
THPO	7066	broad.mit.edu	37	3	184090609	184090609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184090609C>T	ENST00000204615.7	-	6	968	c.754G>A	c.(754-756)Gaa>Aaa	p.E252K	EIF2B5_ENST00000444495.1_Intron|THPO_ENST00000445696.2_Missense_Mutation_p.E248K|THPO_ENST00000421442.2_Missense_Mutation_p.R213Q	NM_000460.2|NM_001177597.1|NM_001177598.1	NP_000451.1|NP_001171068.1|NP_001171069.1	P40225	TPO_HUMAN	thrombopoietin	252					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity	p.E252K(1)		NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCAAGAGTTCGTGTATCCTG	0.557000													26	106					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160850442	160850442	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160850442G>A	ENST00000326245.3	-	6	736	c.621C>T	c.(619-621)atC>atT	p.I207I	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	207	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGACCACAGGGATCACCGGGC	0.443000													72	164					0	0	1	0	0
WDR19	57728	broad.mit.edu	37	4	39245969	39245969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39245969C>T	ENST00000399820.3	+	22	2677	c.2523C>T	c.(2521-2523)gtC>gtT	p.V841V	WDR19_ENST00000288634.7_Silent_p.V681V	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	841					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						CCAGCAGGGTCCTTAAAAGAG	0.428000													30	71					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11022970	11022970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:11022970C>T	ENST00000304623.8	-	17	3099	c.2910G>A	c.(2908-2910)gtG>gtA	p.V970V	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Silent_p.V633V|CTNND2_ENST00000511377.1_Silent_p.V879V|CTNND2_ENST00000458100.2_Silent_p.V537V|CTNND2_ENST00000359640.2_Silent_p.V912V	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	970					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TCTTGGTAATCACTTCGTGCA	0.517000													31	60					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774680	121774680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:121774680C>T	ENST00000264808.3	-	3	433	c.193G>A	c.(193-195)Gga>Aga	p.G65R	PRDM5_ENST00000428209.2_Missense_Mutation_p.G65R|PRDM5_ENST00000515109.1_Missense_Mutation_p.G65R|PRDM5_ENST00000394435.2_Missense_Mutation_p.G65R	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	65	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding	p.G65*(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AAAACTTCTCCCTTACTCCCA	0.448000													28	337					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41582040	41582040	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41582040G>A	ENST00000396942.1	-	7	728	c.645C>T	c.(643-645)caC>caT	p.H215H	ANK1_ENST00000289734.7_Silent_p.H215H|ANK1_ENST00000347528.4_Silent_p.H215H|ANK1_ENST00000379758.2_Silent_p.H215H|ANK1_ENST00000352337.4_Silent_p.H215H|ANK1_ENST00000265709.8_Silent_p.H248H|ANK1_ENST00000396945.1_Silent_p.H215H			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	215	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGTTCTCGTAGTGAGCCGCAA	0.562000													3	5					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51448530	51448530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51448530G>A	ENST00000298355.3	-	8	3016	c.1895C>T	c.(1894-1896)tCg>tTg	p.S632L	TRIM9_ENST00000338969.5_Missense_Mutation_p.S713L	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	632	B30.2/SPRY.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					GTTGGTGTGCGAGTTGTTGTG	0.498000													45	119					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12969475	12969475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12969475G>A	ENST00000251472.4	+	12	1327	c.1288G>A	c.(1288-1290)Gag>Aag	p.E430K	MAST1_ENST00000591495.1_Missense_Mutation_p.E426K	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	430	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CACCTTCGCCGAGAACCCGTT	0.572000													22	40					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55219018	55219018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55219018G>A	ENST00000275493.2	+	5	768	c.591G>A	c.(589-591)ggG>ggA	p.G197G	EGFR_ENST00000420316.2_Silent_p.G197G|EGFR_ENST00000454757.2_Silent_p.G144G|EGFR_ENST00000455089.1_Silent_p.G152G|EGFR_ENST00000442591.1_Silent_p.G197G|EGFR_ENST00000344576.2_Silent_p.G197G|EGFR_ENST00000342916.3_Silent_p.G197G	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	197					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTCCCAATGGGAGCTGCTGGG	0.502000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			23	119					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101773360	101773360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101773360G>A	ENST00000334289.3	-	6	1127	c.532C>T	c.(532-534)Cca>Tca	p.P178S		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	178	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		ACCTCAAATGGGTAGCTAGAT	0.333000													30	68					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120903846	120903846	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120903846C>T	ENST00000263713.5	+	20	1988	c.1774C>T	c.(1774-1776)Cag>Tag	p.Q592*	EPB41L5_ENST00000443902.2_Nonsense_Mutation_p.Q592*|EPB41L5_ENST00000452780.1_Nonsense_Mutation_p.Q592*	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	592						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TGCCAATGTTCAGGATGCTGC	0.308000													12	31					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119216557	119216557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119216557G>A	ENST00000555262.1	-	4	512	c.353C>T	c.(352-354)aCc>aTc	p.T118I	MFRP_ENST00000530681.1_Missense_Mutation_p.T118I|MFRP_ENST00000360167.4_Missense_Mutation_p.T118I|MFRP_ENST00000449574.2_Missense_Mutation_p.T118I|C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		ggtggtgatggtgggggtggt	0.657000													27	61					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760833	62760833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62760833G>A	ENST00000311438.8	-	9	1591	c.1592C>T	c.(1591-1593)gCt>gTt	p.A531V	SLC22A8_ENST00000545207.1_Intron|SLC22A8_ENST00000535878.1_Intron|SLC22A8_ENST00000430500.2_Intron|SLC22A8_ENST00000336232.2_Intron			Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	61					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CTAAGGAAAAGCCCTGGGCCC	0.597000													12	33					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159654630	159654630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159654630C>T	ENST00000297267.9	+	11	3286	c.3086C>T	c.(3085-3087)tCc>tTc	p.S1029F	FNDC1_ENST00000340366.6_Missense_Mutation_p.S966F	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1029						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CGGTCACCTTCCCAGCCCAGG	0.736000													4	5					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34867273	34867273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34867273G>A	ENST00000431794.3	-	12	1438	c.916C>T	c.(916-918)Ctt>Ttt	p.L306F	MYO19_ENST00000268852.9_Missense_Mutation_p.L306F	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	306	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ATATTGCCAAGGTGCAGCAGT	0.607000													2	0					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24121450	24121450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24121450C>T	ENST00000215743.3	+	2	237	c.185C>T	c.(184-186)gCc>gTc	p.A62V	MMP11_ENST00000477567.1_3'UTR	NM_005940.3	NP_005931.2	P24347	MMP11_HUMAN	matrix metallopeptidase 11 (stromelysin 3)	62					collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	27		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				CCGGCACCTGCCCCTGCCACG	0.711000													11	15					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124390562	124390562	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124390562G>A	ENST00000338354.3	+	46	5830	c.5724G>A	c.(5722-5724)ggG>ggA	p.G1908G	DMBT1_ENST00000344338.3_Silent_p.G1898G|DMBT1_ENST00000368955.3_Silent_p.G1898G|DMBT1_ENST00000359586.6_Silent_p.G628G|DMBT1_ENST00000330163.4_Silent_p.G1280G|DMBT1_ENST00000368956.2_Silent_p.G1280G|DMBT1_ENST00000368909.3_Silent_p.G1908G			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1908	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCACCTGGGGGACAGTTTGTG	0.483000													17	39					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7526061	7526061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7526061G>A	ENST00000313599.3	-	14	3642	c.3585C>T	c.(3583-3585)gcC>gcT	p.A1195A	CD163L1_ENST00000396630.1_Silent_p.A1195A|CD163L1_ENST00000416109.2_Silent_p.A1205A			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1195	SRCR 11.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TAGATAAAGGGGCGAGGCTGA	0.567000													16	133					0	0	1	0	0
USP32P3	347716	broad.mit.edu	37	17	20320092	20320092	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:20320092C>T	ENST00000583574.2	+	0	333																											GGGGCTGACCCAGAGGAAGTC	0.567000													8	17					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107230086	107230086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:107230086G>A	ENST00000273980.4	-	3	479	c.32C>T	c.(31-33)gCc>gTc	p.A11V	TBCK_ENST00000394706.3_Missense_Mutation_p.A11V|TBCK_ENST00000432496.2_Missense_Mutation_p.A11V|TBCK_ENST00000394708.2_Missense_Mutation_p.A11V|TBCK_ENST00000361687.4_Missense_Mutation_p.A11V			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	11	Protein kinase.					intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						GAAGGTAAAGGCTCCCATTTC	0.428000													20	38					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926341	1926341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1926341C>T	ENST00000399161.2	-	10	1947	c.1200G>A	c.(1198-1200)gcG>gcA	p.A400A	MYT1L_ENST00000428368.2_Silent_p.A400A	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	400					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CATCCTCCTTCGCACAGCTGG	0.597000													17	25					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125671718	125671718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125671718G>A	ENST00000431078.1	+	24	4138	c.3774G>A	c.(3772-3774)atG>atA	p.M1258I		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1258					cell adhesion|signal transduction	integral to membrane	receptor binding	p.M1258I(1)		NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCGGCATCATGACCCGGTTCC	0.453000													60	123					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25610314	25610314	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:25610314C>T	ENST00000329474.6	+	36	4252	c.3884C>T	c.(3883-3885)gCc>gTc	p.A1295V		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1295					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						CCGAAAGTTGCCCTTCTTCCA	0.478000													55	151					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149241047	149241047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:149241047C>T	ENST00000404807.1	+	5	3016	c.2887C>T	c.(2887-2889)Ccg>Tcg	p.P963S	MBD5_ENST00000407073.1_Intron			Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	968						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TTTTCTCAACCCGAATGTAAA	0.463000													23	39					0	0	1	0	0
NAALADL2	254827	broad.mit.edu	37	3	174951855	174951855	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:174951855C>T	ENST00000454872.1	+	3	808	c.680C>T	c.(679-681)tCt>tTt	p.S227F	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	227					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CCAGGCCCTTCTCCCAGCACT	0.473000													40	69					0	0	1	0	0
PAX2	5076	broad.mit.edu	37	10	102584444	102584444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102584444C>T	ENST00000370296.2	+	9	1578	c.1028C>T	c.(1027-1029)cCt>cTt	p.P343L	PAX2_ENST00000428433.1_Missense_Mutation_p.P343L|PAX2_ENST00000556085.1_Missense_Mutation_p.P319L|PAX2_ENST00000361791.3_Missense_Mutation_p.P320L|PAX2_ENST00000355243.3_Missense_Mutation_p.P320L			Q02962	PAX2_HUMAN	paired box 2	343					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		GGTTACCCCCCTCACGTGCCC	0.612000													60	135					0	0	1	0	0
TUBBP1	92755	broad.mit.edu	37	8	30210015	30210015	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30210015G>A	ENST00000518096.1	+	0	627																											ATCGCATCATGAATACCTTCA	0.532000													18	39					0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52918892	52918892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52918892C>T	ENST00000360465.3	+	7	1213	c.787C>T	c.(787-789)Cat>Tat	p.H263Y	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TCAAAGAATTCATACTGGAGA	0.398000													33	101					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476262	120476262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:120476262C>T	ENST00000355622.6	+	3	1957	c.1856C>T	c.(1855-1857)cCt>cTt	p.P619L	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.P579L	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	619	LRRCT.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CAGGGCATGCCTGTGCTGAGT	0.468000													8	30					0	0	1	0	0
VAC14	55697	broad.mit.edu	37	16	70778438	70778438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70778438G>A	ENST00000261776.5	-	13	1676	c.1416C>T	c.(1414-1416)tcC>tcT	p.S472S		NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	472					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				GGCCTGCGGGGGAGGAAGCGA	0.672000													10	54					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724783	138724783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138724783C>T	ENST00000383163.2	-	1	327	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	110										endometrium(3)|kidney(1)|lung(7)	11						CCTGAGCGTTCGTCGACAGAG	0.617000													12	21					0	0	1	0	0
IFNL2	282616	broad.mit.edu	37	19	39759326	39759326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39759326G>A	ENST00000331982.5	+	2	75	c.20G>A	c.(19-21)gGg>gAg	p.G7E		NM_172138.1	NP_742150.1			interferon, lambda 2																		GACATGACTGGGGACTGCACG	0.647000													5	58					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115963932	115963932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115963932G>A	ENST00000251864.2	+	9	1235	c.1082G>A	c.(1081-1083)aGa>aAa	p.R361K	TDRD1_ENST00000422662.1_Intron|TDRD1_ENST00000369281.2_Missense_Mutation_p.R361K|TDRD1_ENST00000369282.1_Missense_Mutation_p.R361K|TDRD1_ENST00000369280.1_Missense_Mutation_p.R361K	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	361	Tudor 1.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CCATTAAACAGAATTTACCAC	0.353000													18	62					0	0	1	0	0
HOXA5	3202	broad.mit.edu	37	7	27183048	27183048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27183048C>T	ENST00000222726.3	-	1	239	c.179G>A	c.(178-180)gGc>gAc	p.G60D	HOXA3_ENST00000467897.2_Intron|HOXA-AS3_ENST00000521197.1_RNA|HOXA-AS3_ENST00000518848.1_RNA	NM_019102.3	NP_061975.2	P20719	HXA5_HUMAN	homeobox A5	60					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(12)|skin(1)	16						GTGGCCGGAGCCCGAGCGGCC	0.697000													15	41					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36241637	36241637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36241637G>A	ENST00000400445.3	+	56	9062	c.8528G>A	c.(8527-8529)cGa>cAa	p.R2843Q	NBEA_ENST00000310336.4_Missense_Mutation_p.R2843Q|NBEA_ENST00000537702.1_Missense_Mutation_p.R636Q|NBEA_ENST00000540320.1_Missense_Mutation_p.R2843Q|NBEA_ENST00000379922.3_Missense_Mutation_p.R421Q|NBEA_ENST00000379939.2_Missense_Mutation_p.R2840Q	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2843						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TACTATGAACGAGGGCGATTC	0.433000													58	159					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873264	36873264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36873264G>A	ENST00000301807.6	-	21	7925	c.6028C>T	c.(6028-6030)Cct>Tct	p.P2010S	TRANK1_ENST00000429976.2_Missense_Mutation_p.P2560S|TRANK1_ENST00000428977.2_Missense_Mutation_p.P2010S	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2560					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ACCTGGCCAGGGCAGTCCATG	0.572000													26	71					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45725690	45725690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:45725690C>T	ENST00000297323.7	+	13	2225	c.2203C>T	c.(2203-2205)Ctg>Ttg	p.L735L		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	735					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	GCTCTGCTGCCTGGTGGGCAC	0.617000													27	47					0	0	1	0	0
ACADSB	36	broad.mit.edu	37	10	124802595	124802595	+	Missense_Mutation	SNP	C	C	T	rs138063747		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124802595C>T	ENST00000358776.4	+	6	729	c.715C>T	c.(715-717)Cgt>Tgt	p.R239C	ACADSB_ENST00000368869.4_Missense_Mutation_p.R137C|ACADSB_ENST00000496730.2_3'UTR	NM_001609.3	NP_001600.1	P45954	ACDSB_HUMAN	acyl-CoA dehydrogenase, short/branched chain	239					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	CTTAGTAGATCGTGATACTCC	0.398000													45	110					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50139825	50139825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50139825G>A	ENST00000371564.3	-	2	1174	c.955C>T	c.(955-957)Ccc>Tcc	p.P319S	NFATC2_ENST00000414705.1_Missense_Mutation_p.P299S|NFATC2_ENST00000396009.3_Missense_Mutation_p.P319S	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	319					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					ATCTTGGGGGGGATCCCACAA	0.687000													16	30					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061180	9061180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9061180G>A	ENST00000397910.4	-	3	26469	c.26266C>T	c.(26266-26268)Cct>Tct	p.P8756S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8758	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATTGAGCAGGACCTGGGGTG	0.498000													20	79					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51412344	51412344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:51412344C>T	ENST00000319760.6	-	1	104	c.52G>A	c.(52-54)Gat>Aat	p.D18N		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				ACACCAGGATCCTGAGAAAAG	0.428000													16	38					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67402484	67402484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67402484G>A	ENST00000335385.3	-	2	345	c.258C>T	c.(256-258)atC>atT	p.I86I		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	86					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						CCTTGGTGACGATCATCTCAG	0.647000													14	30					0	0	1	0	0
PHACTR2	9749	broad.mit.edu	37	6	144128271	144128271	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:144128271G>A	ENST00000427704.2	+	12	2019		c.e12+1		PHACTR2_ENST00000367582.3_Splice_Site|PHACTR2_ENST00000305766.6_Splice_Site|PHACTR2_ENST00000367584.4_Splice_Site|RP3-468K18.5_ENST00000545614.1_Splice_Site|PHACTR2_ENST00000440869.2_Splice_Site	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2								actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		AGTTTACAAGGTAGGTGACAA	0.313000													28	27					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6081974	6081974	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6081974C>T	ENST00000409021.3	-	7	1616	c.1167G>A	c.(1165-1167)acG>acA	p.T389T	JAKMIP1_ENST00000410077.2_Silent_p.T224T|JAKMIP1_ENST00000409831.1_Silent_p.T389T|JAKMIP1_ENST00000409371.3_Silent_p.T224T|JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000282924.5_Silent_p.T389T	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	389	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCTCATCCCTCGTCAGGCTGA	0.582000													12	40					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20522568	20522568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20522568G>A	ENST00000359062.3	+	1	390	c.350G>A	c.(349-351)gGa>gAa	p.G117E	RP11-284H19.1_ENST00000535755.1_RNA	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	117					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGGCCTCGGGGAGGTGCTCCC	0.706000													4	8					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43441253	43441253	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43441253C>T	ENST00000446844.3	-	0	65				PSG7_ENST00000471557.1_RNA|PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GCGTGTTCTCCTCTGTGGAGA	0.597000													37	80					0	0	1	0	0
MRM1	79922	broad.mit.edu	37	17	34964684	34964684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34964684C>T	ENST00000250156.7	+	5	1134	c.895C>T	c.(895-897)Ctt>Ttt	p.L299F	MRM1_ENST00000585770.1_Missense_Mutation_p.L104F	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	299					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TGCAGGAATTCTTCTTCACTC	0.542000													82	108					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360240	27360240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27360240C>T	ENST00000335524.3	-	3	1483	c.958G>A	c.(958-960)Gaa>Aaa	p.E320K		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	320										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCCTGCTTCCTTCGGCCTT	0.667000													25	60					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121381702	121381702	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121381702A>C	ENST00000297848.3	+	47	5559	c.5289A>C	c.(5287-5289)tcA>tcC	p.S1763S	COL14A1_ENST00000309791.4_Silent_p.S1763S|COL14A1_ENST00000247781.3_Silent_p.S1668S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1763	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACCCCTCATCATGTTCTGCCT	0.532000													23	80					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51092883	51092883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:51092883G>A	ENST00000395542.2	-	14	4121	c.3937C>T	c.(3937-3939)Ctc>Ttc	p.L1313F	COBL_ENST00000265136.7_Missense_Mutation_p.L1231F			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1231										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GTGTTGCTGAGGGTGCCCGTG	0.647000													18	74					0	0	1	0	0
CCDC92	80212	broad.mit.edu	37	12	124421994	124421994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124421994G>A	ENST00000545135.1	-	3	3852	c.556C>T	c.(556-558)Cgc>Tgc	p.R186C	CCDC92_ENST00000545891.1_Missense_Mutation_p.R186C|CCDC92_ENST00000544798.1_Intron|CCDC92_ENST00000238156.3_Missense_Mutation_p.R203C			Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	203										large_intestine(5)|lung(2)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		ATGCGGCGGCGAGGCGTTTCG	0.617000													25	59					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72596824	72596824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:72596824G>A	ENST00000264839.7	+	1	98	c.98G>A	c.(97-99)aGg>aAg	p.R33K	RIMS1_ENST00000348717.5_Missense_Mutation_p.R33K|RIMS1_ENST00000520567.1_Missense_Mutation_p.R33K|RIMS1_ENST00000517960.1_Missense_Mutation_p.R33K|RIMS1_ENST00000521978.1_Missense_Mutation_p.R33K|RIMS1_ENST00000522291.1_Missense_Mutation_p.R33K|RIMS1_ENST00000518273.1_Missense_Mutation_p.R33K|RIMS1_ENST00000491071.2_Missense_Mutation_p.R33K			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	33	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GAAGAGGAGAGGAACATTATC	0.622000													15	15					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51100335	51100335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51100335C>T	ENST00000301180.5	+	21	2455	c.2421C>T	c.(2419-2421)ttC>ttT	p.F807F		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	807						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						GTTTGGTGTTCGTGGTTGGGA	0.363000													38	95					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	780476	780476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:780476C>T	ENST00000297440.6	+	3	821	c.801C>T	c.(799-801)tcC>tcT	p.S267S	HEATR2_ENST00000438961.1_3'UTR|HEATR2_ENST00000313147.5_Silent_p.S267S	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	267							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CGGTGGCCTCCGTGGTGGGCG	0.642000													46	194					0	0	1	0	0
SIX2	10736	broad.mit.edu	37	2	45233467	45233467	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:45233467G>A	ENST00000303077.6	-	2	1037	c.718C>T	c.(718-720)Ctg>Ttg	p.L240L		NM_016932.4	NP_058628.3	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	240						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(6)|large_intestine(3)|lung(8)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	22		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGGGACGGCAGCCCAGGGGGC	0.701000													27	79					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3672097	3672097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3672097C>T	ENST00000294600.2	+	3	603	c.519C>T	c.(517-519)ttC>ttT	p.F173F		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	173										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AGGACCTGTTCTTGGCCAGGC	0.617000													102	226					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328431	57328431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57328431G>A	ENST00000326441.9	-	10	1742	c.1379C>T	c.(1378-1380)tCg>tTg	p.S460L	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.S336L|PEG3_ENST00000593695.1_Missense_Mutation_p.S334L|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.S460L	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	460					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GACACTGAACGACCTCCCACA	0.493000													65	134					0	0	1	0	0
LRFN3	79414	broad.mit.edu	37	19	36431004	36431004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36431004C>T	ENST00000588831.1	+	3	1731	c.677C>T	c.(676-678)tCc>tTc	p.S226F	LRFN3_ENST00000246529.3_Missense_Mutation_p.S226F			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	226					cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCACTCTTCTCCCGCCTGCCC	0.701000													50	130					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167796357	167796357	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:167796357T>A	ENST00000366827.2	-	2	216	c.5A>T	c.(4-6)gAg>gTg	p.E2V	TCP10_ENST00000397829.4_Missense_Mutation_p.E2V|TCP10_ENST00000476779.2_Missense_Mutation_p.E2V			Q12799	TCP10_HUMAN	t-complex 10	29						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		AGGTGTCTTCTCCATGGCAGC	0.667000													5	10					0	0	1	0	0
PLD4	122618	broad.mit.edu	37	14	105396385	105396385	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105396385G>A	ENST00000540372.1	+	6	873	c.681G>A	c.(679-681)gtG>gtA	p.V227V	PLD4_ENST00000392593.4_Silent_p.V220V			Q96BZ4	PLD4_HUMAN	phospholipase D family, member 4	220	PLD phosphodiesterase 1.				lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	13		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	TCTGGGTTGTGGATGGACGGC	0.587000													22	69					0	0	1	0	0
MYCN	4613	broad.mit.edu	37	2	16086016	16086016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:16086016C>T	ENST00000281043.3	+	3	1489	c.1192C>T	c.(1192-1194)Cgg>Tgg	p.R398W		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	398	Helix-loop-helix motif.				regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CAACGACCTTCGGTCCAGCTT	0.567000			A		neuroblastoma								48	114					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118230475	118230475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:118230475C>T	ENST00000402510.2	-	8	1247	c.1248G>A	c.(1246-1248)aaG>aaA	p.K416K		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	416										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						GAAGGTTCTTCTTTTGTTTGC	0.463000													13	11					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94514490	94514490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94514490C>T	ENST00000370225.3	-	18	2763	c.2677G>A	c.(2677-2679)Gcc>Acc	p.A893T	ABCA4_ENST00000535735.1_Missense_Mutation_p.A819T	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	893					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TTTTCCAGGGCTCTTTCTTCT	0.532000													17	79					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38103775	38103775	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38103775C>T	ENST00000308059.6	+	4	810	c.789C>T	c.(787-789)ttC>ttT	p.F263F	DLEC1_ENST00000452631.2_Silent_p.F263F|DLEC1_ENST00000346219.3_Silent_p.F263F			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	263					negative regulation of cell proliferation	cytoplasm		p.F263F(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		TTGCTGAGTTCGAAGATGAGT	0.453000													26	67					0	0	1	0	0
FAM134A	79137	broad.mit.edu	37	2	220047103	220047103	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220047103C>T	ENST00000430297.2	+	9	1520	c.1384C>T	c.(1384-1386)Ccc>Tcc	p.P462S		NM_024293.4	NP_077269.3	Q8NC44	F134A_HUMAN	family with sequence similarity 134, member A	462						endoplasmic reticulum|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	19		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGACCCAGCCCCCTCCCCTTC	0.617000													69	145					0	0	1	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157266	65157266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65157266C>T	ENST00000323544.4	+	6	780	c.652C>T	c.(652-654)Cct>Tct	p.P218S	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	218	Pro-rich.									NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						GACCACCAGCCCTGGTGACAG	0.627000													21	176					0	0	1	0	0
GDF9	2661	broad.mit.edu	37	5	132197639	132197639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132197639G>A	ENST00000378673.2	-	3	1873	c.1007C>T	c.(1006-1008)tCc>tTc	p.S336F	GDF9_ENST00000296875.2_Missense_Mutation_p.S336F			O60383	GDF9_HUMAN	growth differentiation factor 9	336					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGATTGAAGGAAGCTGGGCC	0.483000													36	91					0	0	1	0	0
SRP14	6727	broad.mit.edu	37	15	40328545	40328545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40328545C>T	ENST00000267884.6	-	5	471	c.400G>A	c.(400-402)Gca>Aca	p.A134T	SRP14_ENST00000560773.1_Missense_Mutation_p.A54T|SRP14_ENST00000558720.1_Missense_Mutation_p.A54T|SRP14_ENST00000558527.1_5'UTR	NM_003134.4	NP_003125.3	P37108	SRP14_HUMAN	signal recognition particle 14kDa (homologous Alu RNA binding protein)	134	Ala/Thr-rich.				negative regulation of translational elongation|response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|endoplasmic reticulum signal peptide binding|protein binding			endometrium(1)|skin(1)|upper_aerodigestive_tract(1)	3		all_cancers(109;7.56e-18)|all_epithelial(112;4.02e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.84e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0505)		TACTGtgctgctgttgctgct	0.488000													18	67					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754848	49754848	+	Missense_Mutation	SNP	C	C	T	rs149194608		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49754848C>T	ENST00000304801.3	-	1	205	c.53G>A	c.(52-54)cGa>cAa	p.R18Q		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	18					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CATGATGACTCGCTTCCCTCT	0.418000													33	76					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38646287	38646287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38646287G>A	ENST00000413689.1	-	11	1644	c.1451C>T	c.(1450-1452)tCa>tTa	p.S484L	SCN5A_ENST00000423572.2_Missense_Mutation_p.S484L|SCN5A_ENST00000425664.1_Missense_Mutation_p.S484L|SCN5A_ENST00000333535.4_Missense_Mutation_p.S484L|SCN5A_ENST00000451551.2_Missense_Mutation_p.S484L|SCN5A_ENST00000455624.2_Missense_Mutation_p.S484L|SCN5A_ENST00000449557.2_Missense_Mutation_p.S484L|SCN5A_ENST00000450102.2_Missense_Mutation_p.S484L|SCN5A_ENST00000443581.1_Missense_Mutation_p.S484L|SCN5A_ENST00000414099.2_Missense_Mutation_p.S484L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	484					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CTCAGTTCCTGAAGACATCCG	0.542000													8	42					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634652	32634652	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32634652G>A	ENST00000242310.4	-	1	1015	c.926C>T	c.(925-927)tCt>tTt	p.S309F	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	309					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GTTCCACAAAGACTTCTGGCT	0.498000													40	125					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049182	9049182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9049182C>T	ENST00000397910.4	-	5	32652	c.32449G>A	c.(32449-32451)Gaa>Aaa	p.E10817K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10819	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTAGCTGGTTCACCAGGGGAG	0.483000													61	123					0	0	1	0	0
CLRN3	119467	broad.mit.edu	37	10	129681992	129681992	+	Missense_Mutation	SNP	G	G	A	rs141771225		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129681992G>A	ENST00000368671.3	-	2	539	c.377C>T	c.(376-378)cCg>cTg	p.P126L		NM_152311.3	NP_689524.1	Q8NCR9	CLRN3_HUMAN	clarin 3	126						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				CACCCCCGTCGGCCCCAGGAA	0.572000													28	66					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100551777	100551777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100551777C>T	ENST00000319509.7	+	1	528	c.528C>T	c.(526-528)atC>atT	p.I176I						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TGAGCACGATCGTGTCAACAT	0.473000													42	517					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226453307	226453307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:226453307G>A	ENST00000328205.5	-	10	1558	c.1013C>T	c.(1012-1014)cCg>cTg	p.P338L	LIN9_ENST00000366801.1_Missense_Mutation_p.P287L|LIN9_ENST00000481685.1_Missense_Mutation_p.P303L	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	322					cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		ACTTCTCCACGGCGACTGTCC	0.318000													16	50					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135587422	135587422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135587422C>T	ENST00000513104.1	-	6	1776	c.1494G>A	c.(1492-1494)gaG>gaA	p.E498E	TRPC7_ENST00000426057.2_Silent_p.E382E|TRPC7_ENST00000355180.3_Silent_p.E437E	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	498					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACAGCTGTGCCTCCGTGGCCT	0.582000													9	23					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14508475	14508475	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14508475C>T	ENST00000344204.4	+	57	9262	c.9238C>T	c.(9238-9240)Cga>Tga	p.R3080*	TRIO_ENST00000537187.1_Nonsense_Mutation_p.R2904*|TRIO_ENST00000344135.5_Nonsense_Mutation_p.R579*	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	3080					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GAATGATGTTCGACCTATCCG	0.522000													35	105					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24436349	24436349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:24436349G>A	ENST00000383168.4	-	5	926	c.798C>T	c.(796-798)ttC>ttT	p.F266F	AQP4_ENST00000581374.1_Silent_p.F244F|AQP4_ENST00000583022.1_5'UTR|AQP4-AS1_ENST00000579964.1_RNA|AQP4-AS1_ENST00000582605.1_RNA|AQP4_ENST00000440832.3_Silent_p.F244F	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	266					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					CAGCTTTGCTGAAGGCTTCTT	0.488000													62	266					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949866	27949866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27949866G>A	ENST00000379992.2	-	6	1253	c.804C>T	c.(802-804)gcC>gcT	p.A268A	LINGO2_ENST00000308675.3_Silent_p.A268A	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	268						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		GGTGTTTAAAGGCAAGGAAGG	0.493000													19	141					0	0	1	0	0
MUS81	80198	broad.mit.edu	37	11	65632592	65632592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65632592C>T	ENST00000308110.4	+	13	1726	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	MUS81_ENST00000533035.1_Silent_p.F384F	NM_025128.4	NP_079404.3	Q96NY9	MUS81_HUMAN	MUS81 structure-specific endonuclease subunit	459					DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	13				READ - Rectum adenocarcinoma(159;0.166)		TCAGTGACTTCAACGCAGGAG	0.597000								Homologous recombination					86	190					0	0	1	0	0
ZNF540	163255	broad.mit.edu	37	19	38102515	38102515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38102515C>T	ENST00000592533.1	+	5	666	c.334C>T	c.(334-336)Cgt>Tgt	p.R112C	ZNF540_ENST00000343599.5_Missense_Mutation_p.R112C|ZNF540_ENST00000586792.1_3'UTR|ZNF540_ENST00000316433.4_Missense_Mutation_p.R112C|ZNF540_ENST00000589117.1_Missense_Mutation_p.R80C	NM_152606.4	NP_689819.1			zinc finger protein 540									p.R112C(1)		breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAAAACTCTTCGTCTGAAAGG	0.333000													25	194					0	0	1	0	0
CAPN11	11131	broad.mit.edu	37	6	44147827	44147827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44147827C>T	ENST00000542245.1	+	14	1605	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S	CAPN11_ENST00000398776.1_Missense_Mutation_p.P523S			Q9UMQ6	CAN11_HUMAN	calpain 11	523	Domain III.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TATCATTATTCCCTCCACCTT	0.552000													26	45					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92638150	92638150	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:92638150G>T	ENST00000318445.6	+	3	900	c.686G>T	c.(685-687)gGg>gTg	p.G229V	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.G229V	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	229					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CCAGCCTGCGGGTTTATCCTG	0.428000													21	99					7.92952e-12	7.96446e-12	1	1	0
TFAP4	7023	broad.mit.edu	37	16	4311934	4311934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4311934G>A	ENST00000204517.6	-	4	699	c.371C>T	c.(370-372)tCc>tTc	p.S124F		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	124					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						TCGCTTGGGGGACGAGCCGCT	0.657000											OREG0023575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	17					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22303555	22303555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22303555C>T	ENST00000337107.6	+	1	42	c.23C>T	c.(22-24)tCc>tTc	p.S8F		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	8					cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						CTGCTCAGTTCCCTCCTCCTT	0.527000													86	230					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371795	240371795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240371795C>T	ENST00000319653.9	+	5	3913	c.3683C>T	c.(3682-3684)cCt>cTt	p.P1228L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1228	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCCCTCCACCTGGGACAGGA	0.622000													15	28					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127358154	127358154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127358154C>T	ENST00000342480.6	+	2	176	c.137C>T	c.(136-138)tCc>tTc	p.S46F		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	46					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						ACCTCCACCTCCCTGCTAGAC	0.642000													18	54					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033732	82033732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82033732C>T	ENST00000328945.5	-	3	293	c.166G>A	c.(166-168)Gga>Aga	p.G56R	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	56					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CGGATGTCTCCTTGTATAAAC	0.502000													16	149					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42379582	42379582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42379582C>T	ENST00000290472.3	-	3	265	c.171G>A	c.(169-171)atG>atA	p.M57I		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	57	C2.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TCTTAAACTTCATTCCAGGTG	0.547000													56	141					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248813326	248813326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248813326G>A	ENST00000344889.3	-	1	859	c.860C>T	c.(859-861)cCa>cTa	p.P287L		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTAAATGAGTGGATTGAGCAT	0.493000													20	69					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442346	138442346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138442346G>A	ENST00000344876.4	-	4	3631	c.3245C>T	c.(3244-3246)tCt>tTt	p.S1082F	PCDH18_ENST00000507846.1_Missense_Mutation_p.S861F|PCDH18_ENST00000412923.2_Missense_Mutation_p.S1081F|PCDH18_ENST00000510305.1_Missense_Mutation_p.S293F|PCDH18_ENST00000511115.1_Missense_Mutation_p.S262F	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	1082	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					CCATTTTGAAGAAGGCTGCAC	0.512000													15	32					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110901982	110901982	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110901982G>A	ENST00000265171.5	+	15	2667	c.2221_splice	c.e15-1	p.G741_splice	EGF_ENST00000509793.1_Splice_Site_p.G699_splice|EGF_ENST00000503392.1_Splice_Site_p.G741_splice	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	741	EGF-like 5.				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TCTCTACTAGGAGCAGATCCC	0.408000													29	88					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539443	55539443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55539443G>A	ENST00000220676.1	+	4	3149	c.3001G>A	c.(3001-3003)Gaa>Aaa	p.E1001K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1001					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGACACTGGTGAAGAAGATCT	0.383000													61	189					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756644	15756644	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15756644C>T	ENST00000221307.7	+	3	362	c.314C>T	c.(313-315)aCc>aTc	p.T105I	CYP4F3_ENST00000586182.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000591058.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	105					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						TTCCACCCCACCTACATCAAG	0.592000													19	34					0	0	1	0	0
C22orf29	79680	broad.mit.edu	37	22	19839242	19839242	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19839242G>A	ENST00000405640.1	-	2	1211	c.543C>T	c.(541-543)gaC>gaT	p.D181D	GNB1L_ENST00000405009.1_Intron|C22orf29_ENST00000407472.1_Silent_p.D181D|C22orf29_ENST00000484072.1_Intron|GNB1L_ENST00000403325.1_Intron|GNB1L_ENST00000460402.1_Intron|GNB1L_ENST00000329517.6_Intron|C22orf29_ENST00000328554.4_Silent_p.D181D			Q7L3V2	CV029_HUMAN	chromosome 22 open reading frame 29	181										NS(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	7	Colorectal(54;0.0993)					AACTGTTCGGGTCTTGAACAA	0.617000													8	95					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76828970	76828970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76828970C>T	ENST00000248598.5	-	1	173	c.141G>A	c.(139-141)ggG>ggA	p.G47G	CCDC146_ENST00000285871.4_Intron|CCDC146_ENST00000431197.1_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	47					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						CTTCGCATTTCCCTCTGCTTT	0.493000													41	121					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74489326	74489326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74489326G>A	ENST00000394019.2	-	11	1146	c.749C>T	c.(748-750)cCg>cTg	p.P250L	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000359484.4_Missense_Mutation_p.P186L|SLC4A5_ENST00000358683.4_Missense_Mutation_p.P186L|SLC4A5_ENST00000357822.5_Missense_Mutation_p.P250L|SLC4A5_ENST00000346834.4_Missense_Mutation_p.P250L|SLC4A5_ENST00000377634.4_Missense_Mutation_p.P250L|SLC4A5_ENST00000377632.1_Missense_Mutation_p.P250L|SLC4A5_ENST00000423644.1_Missense_Mutation_p.P250L|SLC4A5_ENST00000483195.1_5'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	250						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GTGTAGACTCGGGCCAGCACC	0.587000													12	48					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66947101	66947101	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66947101C>T	ENST00000299752.4	-	9	1180	c.987G>A	c.(985-987)gaG>gaA	p.E329E	CDH16_ENST00000570262.1_Silent_p.E249E|CDH16_ENST00000565796.1_Silent_p.E329E|CDH16_ENST00000568632.1_Silent_p.E232E|CDH16_ENST00000394055.3_Silent_p.E329E	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	329	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CGTTGTCATTCTCATCCATCA	0.612000													14	136					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2298088	2298088	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2298088G>A	ENST00000381458.5	+	7	1003	c.940G>A	c.(940-942)Gac>Aac	p.D314N	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	314					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	TGTGTACTACGACCCCATGGG	0.517000													54	151					0	0	1	0	0
MRPL14	64928	broad.mit.edu	37	6	44081883	44081883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44081883G>A	ENST00000372014.3	-	3	266	c.135C>T	c.(133-135)gcC>gcT	p.A45A		NM_032111.2	NP_115487.2	Q6P1L8	RM14_HUMAN	mitochondrial ribosomal protein L14	45					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0181)			TGTTCCCCAGGGCACTGTTGT	0.542000													29	301					0	0	1	0	0
TREML1	340205	broad.mit.edu	37	6	41117391	41117391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41117391G>A	ENST00000426005.2	-	6	930	c.887C>T	c.(886-888)tCg>tTg	p.S296L	TREML1_ENST00000437044.2_Missense_Mutation_p.S185L|TREML1_ENST00000373127.4_3'UTR	NM_178174.2	NP_835468.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	296					calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGCCCACACGAGGTCCCTCC	0.547000													29	77					0	0	1	0	0
DMRT2	10655	broad.mit.edu	37	9	1057157	1057157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:1057157G>A	ENST00000382251.3	+	5	1899	c.1570G>A	c.(1570-1572)Gac>Aac	p.D524N	DMRT2_ENST00000358146.2_Missense_Mutation_p.D524N|DMRT2_ENST00000302441.6_Missense_Mutation_p.D524N|DMRT2_ENST00000259622.6_3'UTR|DMRT2_ENST00000382255.3_3'UTR			Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor 2	524					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)|prostate(2)	4		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		ATGTGCAAAAGACCTTTTTGT	0.393000													11	91					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142513531	142513531	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:142513531G>A	ENST00000378004.3	+	19	2053		c.e19-1		ARHGAP26_ENST00000274498.4_Splice_Site	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26						actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCGTTTGCAGATATTTAACA	0.517000													88	193					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10420095	10420095	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10420095C>T	ENST00000397077.1	-	9	1483		c.e9-1		ATP2B2_ENST00000383800.4_Splice_Site|ATP2B2_ENST00000360273.2_Splice_Site|ATP2B2_ENST00000352432.4_Splice_Site|ATP2B2_ENST00000343816.4_Splice_Site			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2						ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						TGTTGTTTGGCTGCAGGGGGC	0.632000													25	65					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116073723	116073723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116073723C>T	ENST00000369271.3	-	7	999	c.699G>A	c.(697-699)cgG>cgA	p.R233R	AFAP1L2_ENST00000304129.4_Silent_p.R233R|AFAP1L2_ENST00000545353.1_Silent_p.R286R	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	233	PH 1.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GCTCCTTCTTCCGCACTTGCT	0.567000													13	60					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52549277	52549277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52549277G>A	ENST00000242839.4	-	2	235	c.79C>T	c.(79-81)Cgt>Tgt	p.R27C	ATP7B_ENST00000542656.1_5'UTR|ATP7B_ENST00000400366.3_Missense_Mutation_p.R27C|ATP7B_ENST00000400370.3_Missense_Mutation_p.R27C|ATP7B_ENST00000418097.2_Missense_Mutation_p.R27C|ATP7B_ENST00000448424.2_Missense_Mutation_p.R27C|ATP7B_ENST00000344297.5_Missense_Mutation_p.R27C	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	27					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TCCCAGGCACGGGTAGGCAAA	0.428000									Wilson disease				16	45					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18456703	18456703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:18456703G>A	ENST00000338745.6	-	5	2273	c.539C>T	c.(538-540)cCt>cTt	p.P180L	SATB1_ENST00000475083.1_5'UTR|SATB1_ENST00000417717.2_Missense_Mutation_p.P180L|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Missense_Mutation_p.P180L	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	180	PDZ-like dimerization domain.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						TTGTTCGGGAGGCAAGTCTTC	0.453000													27	54					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133543152	133543152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133543152C>T	ENST00000409261.1	-	14	1605	c.1232G>A	c.(1231-1233)cGa>cAa	p.R411Q	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.R411Q	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	411							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TAACACTTTTCGCTTCTGTAG	0.413000													27	55					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8422107	8422107	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8422107G>A	ENST00000360416.3	-	21	2484	c.2346C>T	c.(2344-2346)atC>atT	p.I782I	MYH10_ENST00000396239.1_Silent_p.I772I|MYH10_ENST00000269243.4_Silent_p.I751I|MYH10_ENST00000379980.4_Silent_p.I767I	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	751	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CTAAAGCCCGGATCTAAGAGA	0.348000													28	33					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41758327	41758327	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41758327C>T	ENST00000301178.4	+	15	1973	c.1783C>T	c.(1783-1785)Ccc>Tcc	p.P595S	AXL_ENST00000359092.3_Missense_Mutation_p.P586S|AXL_ENST00000593513.1_Missense_Mutation_p.P327S	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	595	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						ATTTGACCATCCCAACGTCAT	0.567000													20	58					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087825	47087825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:47087825G>A	ENST00000374312.1	+	3	1461	c.1042G>A	c.(1042-1044)Gag>Aag	p.E348K	NPY4R_ENST00000395716.1_Missense_Mutation_p.E348K	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		CCCCCTGGAGGAGTCGGAGCA	0.552000													17	142					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113085149	113085149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113085149C>T	ENST00000316851.7	+	7	945	c.945C>T	c.(943-945)gtC>gtT	p.V315V	NCAM1_ENST00000533760.1_Silent_p.V207V|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Silent_p.V324V	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	325	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AGGAGCAGGTCACTCTTACCT	0.458000													8	21					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621303	179621303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179621303G>A	ENST00000589042.1	-	46	11124	c.10900C>T	c.(10900-10902)Cat>Tat	p.H3634Y	TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Missense_Mutation_p.H3463Y|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3321	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGCAGTATGGCACAACTGT	0.423000													9	61					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100330	8100330	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:8100330G>A	ENST00000379328.3	+	3	872	c.304G>A	c.(304-306)Gcc>Acc	p.A102T	GATA3_ENST00000346208.3_Missense_Mutation_p.A102T	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	102				A -> V (in Ref. 2; CAA38877).	aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CGGCGGCAAAGCCCTGGGCAG	0.687000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						29	119					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382267	152382267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152382267C>T	ENST00000271835.3	-	3	1353	c.1291G>A	c.(1291-1293)Gga>Aga	p.G431R	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	431					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTGTCTCCCTGCCCTTCT	0.592000													34	70					0	0	1	0	0
AKR1C4	1109	broad.mit.edu	37	10	5258737	5258737	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5258737C>T	ENST00000380448.1	+	10	1163	c.910C>T	c.(910-912)Cga>Tga	p.R304*	AKR1C4_ENST00000263126.1_Nonsense_Mutation_p.R304*			P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	304					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	18					NADH(DB00157)	CAGAAATTATCGATATGTTGT	0.343000													6	15					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662311	99662311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:99662311C>T	ENST00000373034.4	-	1	2960	c.1285G>A	c.(1285-1287)Ggc>Agc	p.G429S	PCDH19_ENST00000255531.7_Missense_Mutation_p.G429S|PCDH19_ENST00000420881.2_Missense_Mutation_p.G429S	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	429	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						ATGGGCACGCCGCCGTCGCGT	0.552000													12	69					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21032513	21032513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21032513C>T	ENST00000381545.3	+	11	1498	c.1279C>T	c.(1279-1281)Cct>Tct	p.P427S	SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000540229.1_Missense_Mutation_p.P427S|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.P427S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.P427S	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	427					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TCTATATTTCCCTCTAATCTG	0.308000													22	54					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54535276	54535276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54535276C>T	ENST00000566473.2	+	13	1502	c.1502C>T	c.(1501-1503)tCc>tTc	p.S501F	ANKFN1_ENST00000318698.2_Missense_Mutation_p.S501F			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	501										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						ATACCAATATCCTCATCCTCA	0.502000													35	75					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3607626	3607626	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3607626G>A	ENST00000301749.7	-	0	2472				NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000359128.5_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TGACCAAGAGGGATCTGGCCA	0.498000													6	22					0	0	1	0	0
CSNK1E	1454	broad.mit.edu	37	22	38699191	38699191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38699191G>A	ENST00000396832.1	-	3	399	c.139C>T	c.(139-141)Ccc>Tcc	p.P47S	CSNK1E_ENST00000359867.3_Missense_Mutation_p.P47S|CSNK1E_ENST00000403904.1_Missense_Mutation_p.P47S|CSNK1E_ENST00000413574.2_Missense_Mutation_p.P47S|CSNK1E_ENST00000400206.2_Missense_Mutation_p.P47S|CSNK1E_ENST00000405675.3_Missense_Mutation_p.P47S	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	47	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					TGCAGCTGGGGGTGCTTTGTC	0.667000													7	13					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47548875	47548875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47548875C>T	ENST00000273859.3	+	10	1900	c.1631C>T	c.(1630-1632)cCc>cTc	p.P544L	ATP10D_ENST00000504445.1_Missense_Mutation_p.P529L	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	544					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						TTCAGTAGCCCCATTGTAAGT	0.428000													7	31					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111397755	111397755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111397755C>T	ENST00000265162.5	+	1	527	c.185C>T	c.(184-186)tCt>tTt	p.S62F		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	62					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CACCTGCCTTCTTCCACGGCC	0.637000													19	89					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424037	125424037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125424037C>T	ENST00000373686.1	+	1	193	c.193C>T	c.(193-195)Ctt>Ttt	p.L65F				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						ATTCATCCTCCTTGGACTCTC	0.448000													25	69					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150869196	150869196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150869196C>T	ENST00000370353.3	+	4	777	c.387C>T	c.(385-387)ctC>ctT	p.L129L	PRRG3_ENST00000538575.1_Silent_p.L129L			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	129						extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					GGCACACCCTCCCCCGGGTCA	0.652000													43	25					0	0	1	0	0
NRL	4901	broad.mit.edu	37	14	24551935	24551935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24551935G>A	ENST00000561028.1	-	2	442	c.123C>T	c.(121-123)tcC>tcT	p.S41S	NRL_ENST00000397002.2_Silent_p.S41S|NRL_ENST00000396997.1_Silent_p.S41S			P54845	NRL_HUMAN	neural retina leucine zipper	41					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding			lung(2)	2				GBM - Glioblastoma multiforme(265;0.0181)		TGTAAGGTGTGGAGCCCAGTG	0.597000													7	30					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62739651	62739651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62739651C>T	ENST00000371153.4	-	3	1503	c.1125G>A	c.(1123-1125)gaG>gaA	p.E375E	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	375										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CTTTGATTTCCTCTTCCTGCT	0.542000													33	101					0	0	1	0	0
ASL	435	broad.mit.edu	37	7	65557757	65557757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:65557757C>T	ENST00000304874.9	+	17	1355	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	ASL_ENST00000395331.3_Missense_Mutation_p.P398L|ASL_ENST00000395332.3_Missense_Mutation_p.P418L|ASL_ENST00000380839.4_Missense_Mutation_p.P392L|ASL_ENST00000464970.1_3'UTR|AC068533.7_ENST00000450043.1_Intron	NM_000048.3	NP_000039.2	P04424	ARLY_HUMAN	argininosuccinate lyase	418					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(3)|endometrium(3)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	18					L-Arginine(DB00125)	CTCCCCAGCCCCCTGTTCTCG	0.687000													42	129					0	0	1	0	0
ZNF287	57336	broad.mit.edu	37	17	16466515	16466515	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:16466515G>A	ENST00000395824.1	-	5	1277	c.660C>T	c.(658-660)ccC>ccT	p.P220P	ZNF287_ENST00000395825.3_Silent_p.P220P			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	213	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CTTCCAATATGGGAATCACAG	0.368000													14	58					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48567670	48567670	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48567670G>A	ENST00000537810.1	-	29	3812	c.3208C>T	c.(3208-3210)Cgt>Tgt	p.R1070C	FRYL_ENST00000503238.1_Missense_Mutation_p.R1070C|FRYL_ENST00000358350.4_Missense_Mutation_p.R1070C|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507711.1_Missense_Mutation_p.R1070C			O94915	FRYL_HUMAN	FRY-like	1070					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AGACTGTGACGAAGGCTCTGT	0.353000													14	44					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35084740	35084740	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35084740C>T	ENST00000382002.5	-	5	631	c.203_splice	c.e5-1	p.E69_splice	PRLR_ENST00000509934.1_5'UTR|PRLR_ENST00000511486.1_Intron|PRLR_ENST00000310101.5_Splice_Site_p.E69_splice|PRLR_ENST00000513753.1_Splice_Site_p.E69_splice|PRLR_ENST00000348262.3_Splice_Site_p.E69_splice|PRLR_ENST00000397391.3_5'UTR|PRLR_ENST00000542609.1_Splice_Site_p.E69_splice|PRLR_ENST00000342362.5_Intron|PRLR_ENST00000231423.3_Splice_Site_p.E69_splice	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	69	Fibronectin type-III 1.				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ATGAGTGTCTCTCTGCAATAA	0.408000													22	59					0	0	1	0	0
DHRS3	9249	broad.mit.edu	37	1	12677180	12677180	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12677180G>A	ENST00000376223.2	-	1	557	c.174C>T	c.(172-174)ttC>ttT	p.F58F		NM_004753.4	NP_004744.2	O75911	DHRS3_HUMAN	dehydrogenase/reductase (SDR family) member 3	58					retinol metabolic process|visual perception	integral to membrane	electron carrier activity|NADP-retinol dehydrogenase activity|nucleotide binding			cervix(1)|large_intestine(4)|lung(2)|prostate(1)|skin(1)	9	Ovarian(185;0.249)	Lung NSC(185;4.11e-05)|all_lung(284;4.58e-05)|Renal(390;0.000147)|Colorectal(325;0.000585)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;9.25e-07)|COAD - Colon adenocarcinoma(227;0.000326)|BRCA - Breast invasive adenocarcinoma(304;0.000344)|Kidney(185;0.00235)|KIRC - Kidney renal clear cell carcinoma(229;0.00656)|STAD - Stomach adenocarcinoma(313;0.00798)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	CGCGCTCCGCGAACTCGCGGG	0.731000													26	49					0	0	1	0	0
DDO	8528	broad.mit.edu	37	6	110714215	110714215	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110714215G>A	ENST00000368924.3	-	5	888	c.873C>T	c.(871-873)ccC>ccT	p.P291P	DDO_ENST00000368923.3_Silent_p.P232P|DDO_ENST00000368925.1_Silent_p.P263P	NM_003649.2	NP_003640.2	Q99489	OXDD_HUMAN	D-aspartate oxidase	263					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|pancreas(1)|skin(3)	24		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		CGTGGAGGGAGGGCTCCAGAG	0.572000													57	102					0	0	1	0	0
ZNF890P	645700	broad.mit.edu	37	7	5167360	5167360	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5167360G>A	ENST00000422060.2	-	0	491					NR_034163.1																						CCACGTCCCCGAATGACAGTG	0.557000													4	16					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50405101	50405101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50405101C>T	ENST00000435965.1	-	27	2463	c.2290G>A	c.(2290-2292)Ggt>Agt	p.G764S	CACNA2D2_ENST00000423994.2_Missense_Mutation_p.G764S|CACNA2D2_ENST00000266039.3_Missense_Mutation_p.G757S|XXcos-LUCA11.4_ENST00000607121.1_RNA|XXcos-LUCA11.4_ENST00000607088.1_RNA|XXcos-LUCA11.5_ENST00000606589.1_Intron|CACNA2D2_ENST00000479441.1_Missense_Mutation_p.G764S|XXcos-LUCA11.4_ENST00000606259.1_RNA|CACNA2D2_ENST00000424201.2_Missense_Mutation_p.G757S|XXcos-LUCA11.4_ENST00000607362.1_RNA|CACNA2D2_ENST00000360963.3_Missense_Mutation_p.G688S|CACNA2D2_ENST00000395083.1_Missense_Mutation_p.G757S|CACNA2D2_ENST00000429770.1_Missense_Mutation_p.G757S|XXcos-LUCA11.4_ENST00000606665.1_RNA			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	764					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	GTGATGCCACCGTCTGTGGCA	0.642000													19	36					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640122	179640122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179640122C>T	ENST00000589042.1	-	28	6693	c.6469G>A	c.(6469-6471)Gct>Act	p.A2157T	TTN_ENST00000342992.6_Missense_Mutation_p.A2157T|TTN_ENST00000360870.5_Missense_Mutation_p.A2157T|TTN_ENST00000591111.1_Missense_Mutation_p.A2157T|TTN_ENST00000342175.6_Missense_Mutation_p.A2111T|TTN_ENST00000359218.5_Missense_Mutation_p.A2111T|TTN_ENST00000460472.2_Missense_Mutation_p.A2111T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1918	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTCTCCAGCTATGTTGATG	0.433000													18	73					0	0	1	0	0
DEFB1	1672	broad.mit.edu	37	8	6728337	6728337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:6728337G>A	ENST00000297439.3	-	2	237	c.73C>T	c.(73-75)Ctc>Ttc	p.L25F		NM_005218.3	NP_005209.1	P60022	DEFB1_HUMAN	defensin, beta 1	25					chemotaxis|defense response to bacterium|G-protein coupled receptor protein signaling pathway|innate immune response	extracellular region				lung(1)	1			STAD - Stomach adenocarcinoma(24;0.0984)	COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.128)		AGGCCTGTGAGAAAGTTACCA	0.468000													12	35					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233507881	233507881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233507881G>A	ENST00000366624.3	+	6	1911	c.1650G>A	c.(1648-1650)atG>atA	p.M550I	MLK4_ENST00000366623.3_Missense_Mutation_p.M550I	NM_032435.2	NP_115811.2																					GCCCCACAATGATGCCCCGAC	0.557000													31	80					0	0	1	0	0
C8orf31	286122	broad.mit.edu	37	8	144126224	144126224	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144126224G>A	ENST00000395172.1	+	4	697	c.345G>A	c.(343-345)gaG>gaA	p.E115E	C8orf31_ENST00000517653.1_3'UTR	NM_173687.2	NP_775958.1	Q8N9H6	CH031_HUMAN	chromosome 8 open reading frame 31	115										breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGAGCTGGGAGAGAGGGCAAG	0.622000													9	14					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72198665	72198665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72198665G>A	ENST00000537465.1	-	3	321	c.163C>T	c.(163-165)Cac>Tac	p.H55Y	PMFBP1_ENST00000543746.1_5'UTR|PMFBP1_ENST00000355636.6_5'UTR|PMFBP1_ENST00000237353.10_Missense_Mutation_p.H55Y			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	55										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TCCCTTACGTGGCTGCTGTTC	0.522000													9	89					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139741513	139741513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139741513G>A	ENST00000263549.3	-	6	1986	c.1113C>T	c.(1111-1113)ttC>ttT	p.F371F	PARP12_ENST00000470515.1_5'UTR	NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	371	WWE 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					TGGTGAGGATGAAGTGTGGAG	0.498000													42	199					0	0	1	0	0
C5orf28	64417	broad.mit.edu	37	5	43446355	43446355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:43446355G>A	ENST00000500337.2	-	5	948	c.617C>T	c.(616-618)tCt>tTt	p.S206F	C5orf28_ENST00000511525.1_5'UTR|C5orf28_ENST00000510130.1_Missense_Mutation_p.S104F|C5orf28_ENST00000537319.1_Missense_Mutation_p.S75F|C5orf28_ENST00000397080.3_Missense_Mutation_p.S206F|C5orf28_ENST00000512085.1_Missense_Mutation_p.S206F			Q0VDI3	CE028_HUMAN	chromosome 5 open reading frame 28	206						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(5)	9	Lung NSC(6;2.07e-05)					ATGTTTTGAAGACATCATTTG	0.368000													12	68					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85399823	85399823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85399823G>A	ENST00000258888.5	+	6	2627	c.2460G>A	c.(2458-2460)gtG>gtA	p.V820V		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	820					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGATACAAGTGGATGGAAGGA	0.522000													16	78					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157041160	157041160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157041160C>T	ENST00000348165.5	+	19	2940	c.2580C>T	c.(2578-2580)gcC>gcT	p.A860A		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	860	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		ACCACCTCGCCTCCCTAGACC	0.512000													21	173					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8234961	8234961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8234961C>T	ENST00000339754.5	+	1	155	c.77C>T	c.(76-78)gCc>gTc	p.A26V		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	26					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		CCGCCCCGGGCCTCCAACCGC	0.637000													5	23					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16315466	16315466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16315466G>A	ENST00000575728.1	-	2	291	c.259C>T	c.(259-261)Cgg>Tgg	p.R87W	ABCC6_ENST00000574094.1_Intron|ABCC6_ENST00000205557.7_Intron	NM_001079528.3	NP_001072996.1	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0					response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TGCCTCCCCCGAACATTGCCT	0.542000													6	17					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10756116	10756116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10756116G>A	ENST00000416569.2	-	3	1298	c.1272C>T	c.(1270-1272)atC>atT	p.I424I	XKR6_ENST00000304437.2_Silent_p.I145I	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	424						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		AAATGTACACGATCCCTACCA	0.493000													12	22					0	0	1	0	0
PDZD4	57595	broad.mit.edu	37	X	153072226	153072226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153072226C>T	ENST00000164640.4	-	4	648	c.457G>A	c.(457-459)Gag>Aag	p.E153K	PDZD4_ENST00000544474.1_Missense_Mutation_p.E44K|PDZD4_ENST00000475140.1_5'UTR|PDZD4_ENST00000393758.2_Missense_Mutation_p.E78K	NM_032512.2	NP_115901.2	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	153	PDZ.					cell cortex				breast(3)|cervix(1)|endometrium(5)|lung(13)|skin(1)	23	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGTCCTCCTCGTCGTCCGTG	0.632000													7	48					0	0	1	0	0
CGREF1	10669	broad.mit.edu	37	2	27324423	27324423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27324423C>T	ENST00000402394.1	-	6	944	c.676G>A	c.(676-678)Gag>Aag	p.E226K	CGREF1_ENST00000452318.2_Intron|CGREF1_ENST00000405600.1_Missense_Mutation_p.E226K|CGREF1_ENST00000402550.1_Intron|CGREF1_ENST00000260595.5_Missense_Mutation_p.E226K|CGREF1_ENST00000312734.4_Missense_Mutation_p.E226K|CGREF1_ENST00000404694.3_Missense_Mutation_p.E348K	NM_006569.5	NP_006560.3	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	226					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			kidney(1)|lung(4)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCTGGCCCTCAGCTTCCCCT	0.672000													133	270					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78440599	78440599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78440599C>T	ENST00000278550.7	-	22	3690	c.3228G>A	c.(3226-3228)agG>agA	p.R1076R		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TGAGGCTGATCCTCAGGACAG	0.582000													20	47					0	0	1	0	0
ZDHHC23	254887	broad.mit.edu	37	3	113672617	113672617	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113672617C>T	ENST00000330212.3	+	3	531	c.232C>T	c.(232-234)Cga>Tga	p.R78*	ZDHHC23_ENST00000498275.1_Nonsense_Mutation_p.R72*	NM_173570.3	NP_775841.2	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC-type containing 23	78						integral to membrane	acyltransferase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|urinary_tract(2)	16						TGATCGCCTCCGAATTCCTTG	0.453000													47	113					0	0	1	0	0
FGF3	2248	broad.mit.edu	37	11	69625426	69625426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:69625426C>T	ENST00000334134.2	-	3	457	c.367G>A	c.(367-369)Gag>Aag	p.E123K		NM_005247.2	NP_005238.1	P11487	FGF3_HUMAN	fibroblast growth factor 3	123					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of cardiac muscle tissue development|positive regulation of cell division|positive regulation of cell proliferation	extracellular region	growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|urinary_tract(1)	13			LUSC - Lung squamous cell carcinoma(11;5.05e-15)|STAD - Stomach adenocarcinoma(18;0.0278)			TAGCCCAGCTCGTGGATCCGC	0.647000													20	69					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128491636	128491636	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128491636C>T	ENST00000325888.8	+	35	6057	c.5796C>T	c.(5794-5796)ttC>ttT	p.F1932F	FLNC_ENST00000346177.6_Silent_p.F1899F|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1932					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TCGTGCGCTTCGATGACAAGC	0.577000													29	70					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916742	42916742	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42916742C>T	ENST00000316161.4	-	1	891	c.567G>A	c.(565-567)acG>acA	p.T189T	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.T189T|KRBOX1_ENST00000426937.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	189					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCTTGTCCTTCGTGTAGCCGA	0.522000													17	80					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968350	28968350	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28968350G>A	ENST00000359747.4	+	4	266	c.237G>A	c.(235-237)tcG>tcA	p.S79S	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Silent_p.S79S|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	79	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACTGCGAATCGAACCAGAAGA	0.413000													21	57					0	0	1	0	0
DCAF11	80344	broad.mit.edu	37	14	24590594	24590594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24590594C>T	ENST00000446197.3	+	13	1994	c.1267C>T	c.(1267-1269)Cca>Tca	p.P423S	RP11-468E2.6_ENST00000558325.1_Missense_Mutation_p.P12L|DCAF11_ENST00000396941.4_Missense_Mutation_p.P397S|DCAF11_ENST00000396936.1_Missense_Mutation_p.P323S|DCAF11_ENST00000559115.1_Missense_Mutation_p.P423S	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11	423						CUL4 RING ubiquitin ligase complex	protein binding										GCTGAAGCTCCCAGGGGACAG	0.572000													43	110					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108156452	108156452	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108156452C>T	ENST00000273353.3	-	26	3286	c.3230G>A	c.(3229-3231)aGt>aAt	p.S1077N		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1077						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GTTCTCCATACTTTCCCGATT	0.483000													53	205					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039248	11039248	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039248C>T	ENST00000470054.1	-	0	955									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTTAGGTTCCTCTAACAACT	0.418000													22	412					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204955233	204955233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204955233C>T	ENST00000367172.4	+	23	3110	c.2782C>T	c.(2782-2784)Ccg>Tcg	p.P928S	NFASC_ENST00000513543.1_Missense_Mutation_p.P924S|NFASC_ENST00000338586.6_Missense_Mutation_p.P928S|NFASC_ENST00000367169.4_Intron|NFASC_ENST00000360049.4_Missense_Mutation_p.P924S|NFASC_ENST00000367171.4_Missense_Mutation_p.P913S|NFASC_ENST00000401399.1_Intron|NFASC_ENST00000539706.1_Missense_Mutation_p.P924S|NFASC_ENST00000367170.4_Missense_Mutation_p.P928S|NFASC_ENST00000339876.6_Intron|NFASC_ENST00000404907.1_Missense_Mutation_p.P924S|NFASC_ENST00000404076.1_Missense_Mutation_p.P907S|NFASC_ENST00000338515.6_Missense_Mutation_p.P928S			O94856	NFASC_HUMAN	neurofascin	928					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GTTCACCACCCCGGAAGGAGG	0.602000													9	30					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25272796	25272796	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25272796C>T	ENST00000218548.6	+	12	1864	c.1530_splice	c.e12-1	p.L511_splice	ATP12A_ENST00000381946.3_Splice_Site_p.L505_splice	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	505					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TCCTTCCCAGCTCTCCATCCA	0.507000													23	41					0	0	1	0	0
ARFIP1	27236	broad.mit.edu	37	4	153791994	153791994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:153791994C>T	ENST00000451320.2	+	4	456	c.292C>T	c.(292-294)Cct>Tct	p.P98S	ARFIP1_ENST00000511289.1_3'UTR|ARFIP1_ENST00000356064.3_Intron|ARFIP1_ENST00000405727.2_Intron|ARFIP1_ENST00000429148.2_Intron|ARFIP1_ENST00000353617.2_Missense_Mutation_p.P98S			P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	98					intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane			ARFIP1/FHDC1(2)	cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(180;0.093)					TTTAATTGTTCCTGCAGGTAT	0.433000													28	42					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2942488	2942488	+	Missense_Mutation	SNP	G	G	A	rs145270510	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:2942488G>A	ENST00000397461.1	+	10	1444	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	CNTN4_ENST00000397459.2_Missense_Mutation_p.E26K|CNTN4_ENST00000418658.1_Missense_Mutation_p.E354K|CNTN4_ENST00000427331.1_Missense_Mutation_p.E354K|CNTN4_ENST00000448906.2_Missense_Mutation_p.E26K|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000358480.3_Missense_Mutation_p.E135K	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	354	Ig-like C2-type 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AAAAAATGGCGAACCTCTGCT	0.398000													29	79					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238049074	238049074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:238049074C>T	ENST00000366570.4	-	7	1110	c.952G>A	c.(952-954)Gaa>Aaa	p.E318K	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	318	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ATCTGAAGTTCCAGAGTGAGG	0.502000													8	48					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76744936	76744936	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76744936C>T	ENST00000287239.4	+	12	2961	c.2472C>T	c.(2470-2472)ttC>ttT	p.F824F	KAT6B_ENST00000372714.1_Silent_p.F532F|KAT6B_ENST00000490365.1_3'UTR|KAT6B_ENST00000372725.1_Silent_p.F532F|KAT6B_ENST00000372711.1_Silent_p.F641F|KAT6B_ENST00000372724.1_Silent_p.F532F	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	824	Catalytic.|Interaction with BRPF1.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										TCGAGCCATTCCTTTTTTATG	0.378000													12	82					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306200	54306200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54306200G>A	ENST00000545554.1	+	1	1100	c.1100G>A	c.(1099-1101)aGa>aAa	p.R367K	UNC13C_ENST00000537900.1_Missense_Mutation_p.R367K|UNC13C_ENST00000260323.11_Missense_Mutation_p.R367K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	367					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGACACCAGAGAGACTGCCCA	0.383000													5	66					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25457049	25457049	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25457049G>A	ENST00000424208.1	+	0	2516				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						ATTTGGAGGAGGATGCTGGGA	0.507000													107	208					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28540813	28540813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28540813C>T	ENST00000452236.2	-	4	3470	c.2853G>A	c.(2851-2853)aaG>aaA	p.K951K		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	951					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						caatataattctttacagctt	0.343000													13	34					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	136974658	136974658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:136974658G>A	ENST00000508657.1	-	10	1821	c.1107C>T	c.(1105-1107)ggC>ggT	p.G369G	KLHL3_ENST00000541417.1_Intron|KLHL3_ENST00000506491.1_Silent_p.G319G|KLHL3_ENST00000506873.1_5'UTR|KLHL3_ENST00000309755.4_Silent_p.G401G	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	401						cytoplasm|cytoskeleton	actin binding|structural molecule activity	p.G401G(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		TGCCATCAAAGCCTCCCACTG	0.582000													8	21					0	0	1	0	0
BHMT2	23743	broad.mit.edu	37	5	78379618	78379618	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78379618G>A	ENST00000255192.3	+	7	1015	c.949G>A	c.(949-951)Gaa>Aaa	p.E317K	BHMT2_ENST00000521567.1_Missense_Mutation_p.E253K|DMGDH_ENST00000520388.1_Intron	NM_017614.4	NP_060084.2	Q9H2M3	BHMT2_HUMAN	betaine--homocysteine S-methyltransferase 2	317					methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	15		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	ACCAGCTTCAGAAAAACACGG	0.478000													18	29					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102476636	102476636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102476636C>T	ENST00000360184.4	+	31	6409	c.6245C>T	c.(6244-6246)tCc>tTc	p.S2082F		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2082	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CAGCTCTCTTCCCAAAGCCAT	0.408000													18	89					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81864669	81864669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81864669C>T	ENST00000555447.1	-	3	470	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K	STON2_ENST00000267540.2_Missense_Mutation_p.E20K	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	20					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GGTGGCTCTTCATTGAAGGAG	0.483000													18	48					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86772975	86772975	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:86772975C>T	ENST00000373119.4	+	1	224	c.79C>T	c.(79-81)Caa>Taa	p.Q27*	KLHL4_ENST00000373114.4_Nonsense_Mutation_p.Q27*	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	27						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TCATCCTTTTCAAGGTTCCAC	0.493000													46	22					0	0	1	0	0
ATG4C	84938	broad.mit.edu	37	1	63282323	63282323	+	Missense_Mutation	SNP	C	C	T	rs146646910		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:63282323C>T	ENST00000317868.4	+	4	445	c.238C>T	c.(238-240)Cgt>Tgt	p.R80C	ATG4C_ENST00000371120.3_Missense_Mutation_p.R80C	NM_032852.3	NP_116241.2	Q96DT6	ATG4C_HUMAN	autophagy related 4C, cysteine peptidase	80					autophagic vacuole assembly|protein targeting to membrane|proteolysis	cytosol|extracellular region	cysteine-type endopeptidase activity		ATG4C/FBXO38(2)	NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(3)|ovary(1)|prostate(2)	19						AGAAGAATTTCGTAAAGATTT	0.398000													8	88					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55198609	55198609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55198609G>A	ENST00000340465.2	+	3	269	c.183G>A	c.(181-183)agG>agA	p.R61R		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	61						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCAAGATGAGGAATTCATCAT	0.358000													56	143					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41648595	41648595	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41648595C>T	ENST00000313860.7	+	12	1404	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F	LIMCH1_ENST00000513024.1_Silent_p.F279F|LIMCH1_ENST00000396595.3_Silent_p.F296F|LIMCH1_ENST00000381753.4_Silent_p.F284F|LIMCH1_ENST00000512946.1_Silent_p.F450F|LIMCH1_ENST00000514096.1_Silent_p.F291F|LIMCH1_ENST00000509277.1_Silent_p.F284F|LIMCH1_ENST00000512820.1_Silent_p.F438F|LIMCH1_ENST00000508501.1_Silent_p.F450F|LIMCH1_ENST00000503057.1_Silent_p.F835F|LIMCH1_ENST00000512632.1_Silent_p.F450F|LIMCH1_ENST00000511496.1_Silent_p.F291F	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	450					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TTGAGAGGTTCACCATCAGTG	0.493000													54	182					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324482	152324482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152324482C>T	ENST00000388718.5	-	3	5852	c.5780G>A	c.(5779-5781)gGa>gAa	p.G1927E	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1927							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGGTATCTCCTGTCTGTCC	0.502000													101	245					0	0	1	0	0
RPUSD2	27079	broad.mit.edu	37	15	40866204	40866204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40866204C>T	ENST00000315616.7	+	3	1420	c.1382C>T	c.(1381-1383)gCc>gTc	p.A461V	RPUSD2_ENST00000559271.1_Missense_Mutation_p.A400V	NM_152260.1	NP_689473.1	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing 2	461	Poly-Ala.				pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			kidney(4)|lung(4)|skin(3)	11		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		GCTGCAGCTGCCCAGAAGATG	0.552000													29	89					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445619	49445619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49445619G>A	ENST00000301067.7	-	10	1846	c.1847C>T	c.(1846-1848)cCc>cTc	p.P616L		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGGGGAAAGGGGAGACTCCTC	0.602000													17	70					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7565753	7565753	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7565753C>T	ENST00000379802.3	+	7	1280	c.939_splice	c.e7+1	p.S313_splice	DSP_ENST00000418664.2_Splice_Site_p.S313_splice	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	313	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGCCTTCTCCGTAAGTTCAC	0.517000													15	45					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58491601	58491601	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58491601G>A	ENST00000357552.3	-	8	678	c.453C>T	c.(451-453)ttC>ttT	p.F151F	SYCP2_ENST00000371001.2_Silent_p.F151F			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	151					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TGCGAGGTACGAAACTTTCCA	0.294000													7	77					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31901501	31901501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31901501C>T	ENST00000456570.1	+	3	426	c.371C>T	c.(370-372)tCt>tTt	p.S124F	C2_ENST00000299367.5_Missense_Mutation_p.S186F|C2_ENST00000452323.2_Missense_Mutation_p.S63F|C2_ENST00000442278.2_Missense_Mutation_p.S54F|C2_ENST00000469372.1_Missense_Mutation_p.L18F|CFB_ENST00000477310.1_Intron|CFB_ENST00000556679.1_Missense_Mutation_p.S124F|C2_ENST00000418949.2_Missense_Mutation_p.S186F			P00751	CFAB_HUMAN	complement factor B	200	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CTCACGGGGTCTTCGGAGCGG	0.637000													20	59					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088099	86088099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:86088099C>T	ENST00000330753.4	+	2	1008	c.241C>T	c.(241-243)Cct>Tct	p.P81S	FLRT2_ENST00000554746.1_Missense_Mutation_p.P81S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	81					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGCTGGATTTCCTGCAGAACT	0.488000													29	84					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893702	36893702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36893702C>T	ENST00000301807.6	-	13	4799	c.2902G>A	c.(2902-2904)Gac>Aac	p.D968N	TRANK1_ENST00000429976.2_Missense_Mutation_p.D1518N|TRANK1_ENST00000428977.2_Missense_Mutation_p.D968N	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1518					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ATTGCCAAGTCGCTTACACTA	0.428000													10	53					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124393367	124393367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124393367G>A	ENST00000360013.3	+	49	7226	c.7099G>A	c.(7099-7101)Gac>Aac	p.D2367N	KALRN_ENST00000428018.2_Missense_Mutation_p.D638N|KALRN_ENST00000291478.4_Missense_Mutation_p.D670N|KALRN_ENST00000459915.1_Missense_Mutation_p.D458N|KALRN_ENST00000393496.1_Missense_Mutation_p.D707N	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2366	SH3 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCCTGCCAGCGACCATTCCCC	0.597000													9	18					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335551	20335551	+	Missense_Mutation	SNP	G	G	A	rs140222432		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20335551G>A	ENST00000302555.5	-	3	271	c.122C>T	c.(121-123)tCg>tTg	p.S41L	GP2_ENST00000341642.5_Intron|GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.S41L			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	41						anchored to membrane|extracellular region|plasma membrane		p.S41L(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CAGCCCATACGAACTGGCTTC	0.532000													25	37					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553899	140553899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140553899G>A	ENST00000231137.3	+	1	1657	c.1483G>A	c.(1483-1485)Gac>Aac	p.D495N		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		495	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCGTCCCAGGACCCGCACCT	0.662000													49	162					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53227586	53227586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53227586G>A	ENST00000330553.5	-	1	493	c.459C>T	c.(457-459)ttC>ttT	p.F153F		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	153	Coil 1A.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGAAGGAGGCGAACTTGTTGT	0.607000													68	185					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38950815	38950815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38950815G>A	ENST00000357387.3	-	31	3165	c.3135C>T	c.(3133-3135)ttC>ttT	p.F1045F	RICTOR_ENST00000296782.5_Silent_p.F1045F	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1045	Ser-rich.				actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					CCTCCAATATGAACATACCTA	0.333000													29	66					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12144525	12144525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12144525G>A	ENST00000263932.2	+	2	290	c.68G>A	c.(67-69)cGa>cAa	p.R23Q	TNFRSF8_ENST00000417814.2_Intron	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	23					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCAGGATCGACCCTTCGAG	0.597000													10	104					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40231823	40231823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:40231823G>A	ENST00000302541.6	+	10	1876	c.1534G>A	c.(1534-1536)Gag>Aag	p.E512K	MYRIP_ENST00000444716.1_Missense_Mutation_p.E512K|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Missense_Mutation_p.E423K|MYRIP_ENST00000539167.1_Missense_Mutation_p.E325K|MYRIP_ENST00000425621.1_Missense_Mutation_p.E512K	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	512	Actin-binding.|Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GGACAGCAGCGAGCCGGAGGA	0.647000													34	73					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36216190	36216190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36216190C>T	ENST00000420124.1	+	11	3598	c.3598C>T	c.(3598-3600)Ccc>Tcc	p.P1200S	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Missense_Mutation_p.P1200S																							GCCAGGGGGCCCCCCGATGGT	0.597000													11	20					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6594260	6594260	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6594260C>T	ENST00000433363.2	-	10	1509		c.e10-1		SLC13A5_ENST00000293800.6_Splice_Site|SLC13A5_ENST00000381074.4_Splice_Site|SLC13A5_ENST00000573648.1_Splice_Site	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5							integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						GCCCCGAGGCCTGGGAAGCAC	0.642000													35	36					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23292929	23292929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:23292929G>A	ENST00000358689.4	-	11	1671	c.1436C>T	c.(1435-1437)tCt>tTt	p.S479F	ENTPD4_ENST00000417069.2_Missense_Mutation_p.S471F|ENTPD4_ENST00000521321.1_5'UTR|ENTPD4_ENST00000356206.6_Missense_Mutation_p.S471F	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	479					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		GTCAGCATGAGAGGCGTACAG	0.478000													7	29					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325159	31325159	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31325159C>T	ENST00000269197.5	+	12	5347	c.5347C>T	c.(5347-5349)Caa>Taa	p.Q1783*		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1783					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ATTGCCTCTTCAAACTACCTC	0.512000													20	51					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140588852	140588852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140588852G>A	ENST00000239450.2	+	1	562	c.373G>A	c.(373-375)Gat>Aat	p.D125N	PCDHB12_ENST00000541609.1_Intron	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		125	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCAGGTCAGGGATATAAATGA	0.443000													61	143					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50367249	50367249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50367249C>T	ENST00000331340.3	+	3	211	c.56C>T	c.(55-57)cCt>cTt	p.P19L	IKZF1_ENST00000346667.4_Missense_Mutation_p.P19L|IKZF1_ENST00000357364.4_Missense_Mutation_p.P19L|IKZF1_ENST00000439701.1_Missense_Mutation_p.P19L|IKZF1_ENST00000359197.5_Missense_Mutation_p.P19L|IKZF1_ENST00000438033.1_Missense_Mutation_p.P19L|IKZF1_ENST00000343574.5_Missense_Mutation_p.P19L|IKZF1_ENST00000492782.1_3'UTR|IKZF1_ENST00000440768.2_Missense_Mutation_p.P19L|IKZF1_ENST00000349824.4_Missense_Mutation_p.P19L|IKZF1_ENST00000413698.1_Missense_Mutation_p.P19L	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	19					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(33)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GAAAGCCCCCCTGTAAGCGAT	0.597000			"""D,T"""	BCL6	"""ALL, DLBCL"""								5	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179486595	179486595	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179486595C>T	ENST00000589042.1	-	244	45278	c.45054G>A	c.(45052-45054)gcG>gcA	p.A15018A	TTN_ENST00000342992.6_Silent_p.A12450A|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.A13377A|TTN_ENST00000342175.6_Silent_p.A6145A|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.A6078A|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.A5953A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13377	Fibronectin type-III 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAAGTTCTCGCTGTCCTTA	0.378000													19	35					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702748	30702748	+	Silent	SNP	C	C	T	rs112301482		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30702748C>T	ENST00000256246.2	-	1	3860	c.3786G>A	c.(3784-3786)gcG>gcA	p.A1262A		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1262								p.A1262A(1)		NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CGTCAGTTTTCGCCTTTGTGT	0.313000													14	73					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44069433	44069433	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44069433C>T	ENST00000359947.4	+	16	2950	c.2610C>T	c.(2608-2610)ttC>ttT	p.F870F	PTPRF_ENST00000422171.2_Silent_p.F218F|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Silent_p.F861F|PTPRF_ENST00000372414.3_Silent_p.F870F|PTPRF_ENST00000438120.1_Silent_p.F861F	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	870	Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCATAGATTTCGGCAAGGATG	0.637000													21	73					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139839014	139839014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139839014G>A	ENST00000303045.6	-	6	1302	c.856C>T	c.(856-858)Ccc>Tcc	p.P286S	COL22A1_ENST00000435777.1_Missense_Mutation_p.P286S	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	286	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AAACCTTGGGGGAACACATCC	0.522000										HNSCC(7;0.00092)			5	41					0	0	1	0	0
INSL5	10022	broad.mit.edu	37	1	67263912	67263912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:67263912G>A	ENST00000304526.2	-	2	226	c.192C>T	c.(190-192)tcC>tcT	p.S64S		NM_005478.4	NP_005469.2	Q9Y5Q6	INSL5_HUMAN	insulin-like 5	64						extracellular region	hormone activity			breast(2)|endometrium(1)|lung(5)	8						GGAGCTGGAAGGAGTTTCCTG	0.478000													19	76					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178392827	178392827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178392827G>A	ENST00000320129.3	+	5	1725	c.1422G>A	c.(1420-1422)gaG>gaA	p.E474E	ZNF454_ENST00000519564.1_Silent_p.E474E	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		AAATCTGTGAGAAAGCCTTTA	0.383000													48	84					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21108367	21108367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21108367C>T	ENST00000377122.4	-	20	2437	c.2041G>A	c.(2041-2043)Gag>Aag	p.E681K	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	681					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CTCAGCTGCTCCTGGTTTCGC	0.428000													84	153					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156638365	156638365	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156638365G>A	ENST00000296518.7	+	8	1836	c.1627G>A	c.(1627-1629)Gat>Aat	p.D543N	GUCY1A3_ENST00000393832.3_Missense_Mutation_p.D285N|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.D543N|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.D543N|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.D543N|GUCY1A3_ENST00000511108.1_Missense_Mutation_p.D543N|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.D543N			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	543	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CAAAGAGAGTGATACTCATGC	0.433000													19	90					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396866	154396866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154396866G>A	ENST00000435029.4	+	1	3607	c.3447G>A	c.(3445-3447)gaG>gaA	p.E1149E		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1149	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATCCTACCGAGGTGACCCCAG	0.527000													35	59					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397806	125397806	+	Missense_Mutation	SNP	G	G	A	rs143365567		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125397806G>A	ENST00000536769.1	-	1	2088	c.512C>T	c.(511-513)cCc>cTc	p.P171L	UBC_ENST00000546120.1_Intron|UBC_ENST00000538617.1_Intron|UBC_ENST00000339647.5_Missense_Mutation_p.P171L			P0CG48	UBC_HUMAN	ubiquitin C	171	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGTGTCACTGGGCTCCACCTC	0.517000													24	198					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77343191	77343191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77343191G>A	ENST00000451710.3	-	37	6148	c.5911C>T	c.(5911-5913)Cat>Tat	p.H1971Y	TRPM6_ENST00000361255.3_Missense_Mutation_p.H1962Y|TRPM6_ENST00000360774.1_Missense_Mutation_p.H1967Y|TRPM6_ENST00000376871.3_Missense_Mutation_p.H804Y|TRPM6_ENST00000376872.3_Missense_Mutation_p.H922Y|TRPM6_ENST00000449912.2_Missense_Mutation_p.H1962Y			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1967	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GAGTTACAATGATGTTTTGCA	0.398000													20	62					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62903542	62903542	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:62903542C>T	ENST00000512091.1	+	23	4228	c.3481C>T	c.(3481-3483)Cga>Tga	p.R1161*	LPHN3_ENST00000504896.1_Nonsense_Mutation_p.R1161*|LPHN3_ENST00000545650.1_Nonsense_Mutation_p.R1161*|LPHN3_ENST00000507164.1_Nonsense_Mutation_p.R1220*|LPHN3_ENST00000514157.1_Nonsense_Mutation_p.R1152*|LPHN3_ENST00000511324.1_Nonsense_Mutation_p.R1220*|LPHN3_ENST00000508693.1_Nonsense_Mutation_p.R1229*|LPHN3_ENST00000506746.1_Nonsense_Mutation_p.R1220*|LPHN3_ENST00000506700.1_Nonsense_Mutation_p.R1152*|LPHN3_ENST00000514591.1_Nonsense_Mutation_p.R1161*|LPHN3_ENST00000506720.1_Nonsense_Mutation_p.R1229*|LPHN3_ENST00000509896.1_Nonsense_Mutation_p.R1229*|LPHN3_ENST00000507625.1_Nonsense_Mutation_p.R1220*|LPHN3_ENST00000508946.1_Nonsense_Mutation_p.R1161*|LPHN3_ENST00000514996.1_Nonsense_Mutation_p.R1152*			Q9HAR2	LPHN3_HUMAN	latrophilin 3	1139					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						ATCTGGTTCTCGAACTCCTGG	0.428000													30	72					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964210	70964210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70964210G>A	ENST00000357250.6	-	25	1846	c.1688C>T	c.(1687-1689)cCt>cTt	p.P563L	COL9A1_ENST00000370499.4_Missense_Mutation_p.P320L|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000320755.7_Missense_Mutation_p.P320L	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	563	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						ATCACCAGGAGGCCCAGGTTT	0.388000													8	70					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34888231	34888231	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34888231C>T	ENST00000360581.1	+	8	1109	c.981C>T	c.(979-981)ccC>ccT	p.P327P	NPSR1_ENST00000359791.1_Silent_p.P327P|NPSR1_ENST00000381539.3_Silent_p.P327P|NPSR1_ENST00000381542.1_Silent_p.P261P|NPSR1_ENST00000531252.1_Silent_p.P316P	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	327						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CCATCAACCCCCTCATCTACT	0.502000													44	152					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131878824	131878824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131878824G>A	ENST00000359827.3	-	14	3815	c.2853C>T	c.(2851-2853)ttC>ttT	p.F951F	PLXNA4_ENST00000321063.4_Silent_p.F951F			Q9HCM2	PLXA4_HUMAN	plexin A4	951	IPT/TIG 1.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GACTCACCATGAAGTAATAGA	0.592000													14	51					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	819602	819602	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:819602G>A	ENST00000293892.3	-	16	2987	c.2988C>T	c.(2986-2988)ccC>ccT	p.P996P	MSLNL_ENST00000442466.1_Silent_p.P645P			Q96KJ4	MSLNL_HUMAN	mesothelin-like	645					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CCATCGCCAGGGGCAGGTACC	0.652000													10	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179605677	179605677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179605677C>T	ENST00000589042.1	-	48	12507	c.12283G>A	c.(12283-12285)Gag>Aag	p.E4095K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E3778K|TTN_ENST00000342175.6_Missense_Mutation_p.E3924K|TTN_ENST00000359218.5_Missense_Mutation_p.E3857K|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E3732K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3778							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAATATGCTCATAAGATAGT	0.408000													35	76					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205038639	205038639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205038639G>A	ENST00000331830.4	+	17	2430	c.2146G>A	c.(2146-2148)Gga>Aga	p.G716R		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	716	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGCACCCTCAGGACTCAGCGG	0.597000													10	31					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54586243	54586243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54586243G>A	ENST00000545554.1	+	10	3969	c.3969G>A	c.(3967-3969)atG>atA	p.M1323I	UNC13C_ENST00000537900.1_Missense_Mutation_p.M1321I|UNC13C_ENST00000260323.11_Missense_Mutation_p.M1323I			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1323					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTGGAGAAATGGATGTCTGGT	0.343000													19	228					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169523	207169523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207169523G>A	ENST00000374423.3	+	5	657	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	91	Poly-Glu.						nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TGAAGAAGAGGAAGAGGATGA	0.438000													9	41					0	0	1	0	0
CEACAM1	634	broad.mit.edu	37	19	43023314	43023314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43023314C>T	ENST00000161559.6	-	5	1166	c.1032G>A	c.(1030-1032)gtG>gtA	p.V344V	CEACAM1_ENST00000358394.3_Intron|CEACAM1_ENST00000352591.5_Intron|LIPE-AS1_ENST00000594688.1_RNA|CEACAM1_ENST00000351134.3_Intron|CEACAM1_ENST00000599389.1_Intron|CEACAM1_ENST00000403461.1_Intron|LIPE-AS1_ENST00000457234.2_RNA|CEACAM1_ENST00000403444.3_Silent_p.V344V|CEACAM1_ENST00000308072.4_Intron|LIPE-AS1_ENST00000594624.2_RNA	NM_001712.4	NP_001703.2	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	344	Ig-like C2-type 3.				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	17		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	AGGTCAGGTTCACAGAGTCCT	0.502000													56	98					0	0	1	0	0
FBLN5	10516	broad.mit.edu	37	14	92347740	92347740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92347740C>T	ENST00000267620.10	-	10	1177	c.1008G>A	c.(1006-1008)agG>agA	p.R336R	FBLN5_ENST00000342058.4_Silent_p.R295R|FBLN5_ENST00000556154.1_Silent_p.R300R			Q9UBX5	FBLN5_HUMAN	fibulin 5	295					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				ACGTGTGGTTCCTGTGCTCAC	0.557000													29	72					0	0	1	0	0
HTR1F	3355	broad.mit.edu	37	3	88039932	88039932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:88039932G>A	ENST00000319595.4	+	1	87	c.33G>A	c.(31-33)ttG>ttA	p.L11L		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	11					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity	p.L11L(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	ATCAAAACTTGACCTCAGAGG	0.373000													36	120					0	0	1	0	0
ZNF175	7728	broad.mit.edu	37	19	52091439	52091439	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52091439A>G	ENST00000262259.2	+	5	2213	c.1855A>G	c.(1855-1857)Aaa>Gaa	p.K619E	ZNF175_ENST00000436511.2_Intron	NM_007147.2	NP_009078.1	Q9Y473	ZN175_HUMAN	zinc finger protein 175	619					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		TGTCTGTTACAAATGTGGGAA	0.433000													69	145					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9014636	9014636	+	Missense_Mutation	SNP	G	G	A	rs34857031		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9014636G>A	ENST00000397910.4	-	31	38542	c.38339C>T	c.(38338-38340)cCt>cTt	p.P12780L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12782	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCCACTCCAGGGCTTTTGGG	0.562000													27	92					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22705588	22705588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:22705588G>A	ENST00000376603.2	+	11	1871	c.1729G>A	c.(1729-1731)Gtg>Atg	p.V577M	SPAG6_ENST00000376624.3_Missense_Mutation_p.V501M|SPAG6_ENST00000538630.1_Missense_Mutation_p.V476M|SPAG6_ENST00000313311.6_Missense_Mutation_p.G452D|SPAG6_ENST00000376601.1_Missense_Mutation_p.V262M			O75602	SPAG6_HUMAN	sperm associated antigen 6	501					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						TCTGCAGAGGGTGGACAGCTA	0.358000													39	107					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54964810	54964810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54964810C>T	ENST00000326764.5	+	5	880	c.401C>T	c.(400-402)cCc>cTc	p.P134L	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	105							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CCATCCGCACCCCAACACCAA	0.567000													19	67					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43416923	43416923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43416923C>T	ENST00000244533.3	+	18	4459	c.4100C>T	c.(4099-4101)gCt>gTt	p.A1367V	ABCC10_ENST00000372530.4_Missense_Mutation_p.A1395V	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	1395	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TTGGCCAGGGCTCTCCTCACA	0.592000													8	63					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77386669	77386669	+	Missense_Mutation	SNP	C	C	T	rs139669465	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77386669C>T	ENST00000451710.3	-	25	3723	c.3486G>A	c.(3484-3486)atG>atA	p.M1162I	TRPM6_ENST00000376864.4_Missense_Mutation_p.M1162I|TRPM6_ENST00000361255.3_Missense_Mutation_p.M1157I|TRPM6_ENST00000360774.1_Missense_Mutation_p.M1162I|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Missense_Mutation_p.M1157I			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1162					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TCACATCTTCCATCTTCTCAT	0.363000													7	83					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16967672	16967672	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:16967672G>A	ENST00000377833.4	-	42	6438	c.6373C>T	c.(6373-6375)Caa>Taa	p.Q2125*		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2125	CUB 15.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGGCCACTTTGGACCAGGACG	0.502000													26	63					0	0	1	0	0
MYL7	58498	broad.mit.edu	37	7	44178607	44178607	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44178607G>A	ENST00000458240.1	-	6	648	c.360C>T	c.(358-360)ttC>ttT	p.F120F	MYL7_ENST00000434895.1_5'UTR|MYL7_ENST00000223364.3_Silent_p.F147F			Q01449	MLRA_HUMAN	myosin, light chain 7, regulatory	147	EF-hand 2.				actin filament-based movement|smooth muscle contraction	A band|myosin complex	ATPase activity, coupled|calcium ion binding|microfilament motor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	12						GTGTCAGGGCGAACATCTGCT	0.612000													17	42					0	0	1	0	0
POMC	5443	broad.mit.edu	37	2	25384054	25384054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:25384054C>T	ENST00000405623.1	-	3	1155	c.700G>A	c.(700-702)Gac>Aac	p.D234N	POMC_ENST00000264708.3_Missense_Mutation_p.D234N|POMC_ENST00000395826.2_Missense_Mutation_p.D234N|POMC_ENST00000380794.1_Missense_Mutation_p.D234N			P01189	COLI_HUMAN	proopiomelanocortin	234					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	TAGCGCTTGTCCTTGGGCGGG	0.637000													4	42					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196648906	196648906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196648906C>T	ENST00000367429.4	+	6	1013	c.773C>T	c.(772-774)cCg>cTg	p.P258L	CFH_ENST00000439155.2_Missense_Mutation_p.P258L|CFH_ENST00000359637.2_Missense_Mutation_p.P194L	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	258	Sushi 4.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GGATGGCGTCCGTTGCCTTCA	0.289000													5	54					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143054022	143054022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143054022C>T	ENST00000409408.1	-	6	2328	c.620G>A	c.(619-621)aGc>aAc	p.S207N	FAM131B_ENST00000409578.1_Missense_Mutation_p.S223N|FAM131B_ENST00000409222.3_Missense_Mutation_p.S207N|FAM131B_ENST00000443739.2_Missense_Mutation_p.S235N|FAM131B_ENST00000409346.1_Missense_Mutation_p.S207N			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	207										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					GGACTGATCGCTGGCTTCCCA	0.557000													14	56					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685415	248685415	+	Silent	SNP	C	C	T	rs146219175	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248685415C>T	ENST00000343414.4	+	1	500	c.468C>T	c.(466-468)tcC>tcT	p.S156S		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCATCACCTCCCTAATTCAGT	0.577000													11	38					0	0	1	0	0
BCL10	8915	broad.mit.edu	37	1	85733503	85733503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85733503G>A	ENST00000370580.1	-	3	1246	c.509C>T	c.(508-510)tCt>tTt	p.S170F		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	170					apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		ATTCAGAGAAGAATTAGTAGA	0.448000			T	IGH@	MALT								20	150					0	0	1	0	0
ANKLE1	126549	broad.mit.edu	37	19	17394122	17394122	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17394122C>T	ENST00000394458.3	+	5	825	c.549C>T	c.(547-549)ggC>ggT	p.G183G	ANKLE1_ENST00000404085.1_Silent_p.G205G|ANKLE1_ENST00000598347.1_Silent_p.G183G|ANKLE1_ENST00000594072.1_Silent_p.G172G|ANKLE1_ENST00000433424.2_Silent_p.G237G	NM_152363.4	NP_689576.4	Q8NAG6	ANKL1_HUMAN	ankyrin repeat and LEM domain containing 1	183						nuclear envelope				large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	7						GGGACATTGGCTTGGAGGCTG	0.602000													29	126					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7242035	7242035	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7242035G>A	ENST00000542285.1	-	5	768	c.619C>T	c.(619-621)Ctg>Ttg	p.L207L				P00736	C1R_HUMAN	complement component 1, r subcomponent	208	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGGTACTCCAGGCTGGAGATG	0.632000													23	15					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37602795	37602795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37602795C>T	ENST00000328544.3	-	2	1581	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K	SSTR3_ENST00000402501.1_Missense_Mutation_p.E350K	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	350	Glu-rich (acidic).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						tcatcctcctcctcAGTCTTC	0.687000													26	51					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038913	11038913	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11038913G>A	ENST00000470054.1	-	0	1290									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTTGGGGAGGAAGACACATC	0.423000													28	614					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160826660	160826660	+	Splice_Site	SNP	G	G	A	rs113304621	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160826660G>A	ENST00000283243.7	-	18	2865	c.2660_splice	c.e18+1	p.R887_splice	PLA2R1_ENST00000392771.1_Splice_Site_p.R887_splice	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	887	C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding	p.R887C(1)	PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GGTTCATACCGAAATTCATCA	0.318000													27	66					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178423749	178423749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:178423749C>T	ENST00000448150.3	+	12	2941	c.2123C>T	c.(2122-2124)tCc>tTc	p.S708F	RASAL2_ENST00000367649.3_Missense_Mutation_p.S726F|RASAL2_ENST00000462775.1_Missense_Mutation_p.S578F	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	578					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						GTTTTGCATTCCTTACTGTGG	0.413000													23	93					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123844591	123844591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123844591C>T	ENST00000369005.1	+	4	2916	c.2576C>T	c.(2575-2577)tCt>tTt	p.S859F	TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.S859F|TACC2_ENST00000334433.3_Missense_Mutation_p.S859F|TACC2_ENST00000515273.1_Missense_Mutation_p.S859F|TACC2_ENST00000453444.2_Missense_Mutation_p.S859F	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	859						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AAAGAGACTTCTCCAAGCCAT	0.512000													41	88					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43495431	43495431	+	Missense_Mutation	SNP	C	C	T	rs150037117	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43495431C>T	ENST00000300215.3	-	11	2208	c.1751G>A	c.(1750-1752)cGa>cAa	p.R584Q	EPB42_ENST00000441366.2_Missense_Mutation_p.R554Q|EPB42_ENST00000540029.1_Missense_Mutation_p.R476Q|EPB42_ENST00000563128.1_5'UTR			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	554					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GGGTGGGTTTCGCTCAAAATT	0.478000													24	79					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208798	140208798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140208798G>A	ENST00000529310.1	+	1	1236	c.1122G>A	c.(1120-1122)gtG>gtA	p.V374V	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Silent_p.V374V|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAATTAGCGTGAACGACCTCG	0.498000													60	160					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10089654	10089654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10089654C>T	ENST00000264828.3	-	40	2962	c.2877G>A	c.(2875-2877)ggG>ggA	p.G959G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	959	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GTCCCAGTTCCCCCTACAGGA	0.622000													3	16					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740765	140740765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140740765C>T	ENST00000522605.1	+	1	1063	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTATCTACTCCCCTACCGGA	0.458000													21	60					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123301256	123301256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123301256C>T	ENST00000296513.2	+	3	217	c.32C>T	c.(31-33)tCg>tTg	p.S11L	ADAD1_ENST00000388725.2_5'UTR|ADAD1_ENST00000388724.2_Missense_Mutation_p.S11L	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	11					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTTCAGAGTTCGCAGGTCCCC	0.433000													16	43					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237167	56237167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56237167C>T	ENST00000312240.2	-	1	847	c.807G>A	c.(805-807)ggG>ggA	p.G269G		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					CCACCATCTTCCCCTGCTCCA	0.463000													7	33					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36848065	36848065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36848065G>A	ENST00000279024.4	-	11	2794	c.2523C>T	c.(2521-2523)gtC>gtT	p.V841V		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	841										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GGCCCAGGCGGACACGGAGCT	0.622000													27	95					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21228550	21228550	+	Silent	SNP	G	G	A	rs75165693		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21228550G>A	ENST00000233242.1	-	26	11317	c.11190C>T	c.(11188-11190)ttC>ttT	p.F3730F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3730					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGGAATAATGAATTTATCAG	0.408000													54	157					0	0	1	0	0
HTR3D	200909	broad.mit.edu	37	3	183756736	183756736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183756736C>T	ENST00000382489.3	+	8	1338	c.1338C>T	c.(1336-1338)atC>atT	p.I446I	HTR3D_ENST00000428798.2_Silent_p.I396I|HTR3D_ENST00000334128.2_Silent_p.I271I|HTR3D_ENST00000453435.1_Silent_p.I225I	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	446						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCTCCATCATCACCGTCATAT	0.567000													32	126					0	0	1	0	0
MED26	9441	broad.mit.edu	37	19	16686990	16686990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16686990C>T	ENST00000263390.3	-	3	1913	c.1651G>A	c.(1651-1653)Gat>Aat	p.D551N	CTD-3222D19.2_ENST00000409035.1_Intron	NM_004831.3	NP_004822.2	O95402	MED26_HUMAN	mediator complex subunit 26	551					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	8						CTGTCGAGATCGTCCTGTGTG	0.642000													24	59					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53586454	53586454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:53586454G>A	ENST00000025008.5	-	7	1476	c.953C>T	c.(952-954)cCt>cTt	p.P318L	RB1CC1_ENST00000539297.1_Missense_Mutation_p.P318L|RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Missense_Mutation_p.P318L	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	318					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CACATCATTAGGTCTATCTTG	0.338000													14	55					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32740570	32740570	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32740570C>T	ENST00000373564.3	+	2	338	c.338C>T	c.(337-339)tCc>tTc	p.S113F	LCK_ENST00000333070.4_Intron|LCK_ENST00000336890.5_Intron			P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	0	SH3.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GCTCGGTTCTCCCTGATGCCC	0.582000			T	TRB@	T-ALL								27	72					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131412	72131412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:72131412C>T	ENST00000265381.4	-	2	937	c.715G>A	c.(715-717)Gac>Aac	p.D239N		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	239	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GAGCGCTCGTCGTAATGGTGC	0.716000													11	17					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22170068	22170068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22170068C>T	ENST00000397126.4	-	3	324	c.176G>A	c.(175-177)gGa>gAa	p.G59E	ZNF208_ENST00000599916.1_Missense_Mutation_p.G59E|ZNF208_ENST00000597040.1_Missense_Mutation_p.G27E|ZNF208_ENST00000601773.1_Missense_Mutation_p.G59E	NM_007153.3	NP_009084.2			zinc finger protein 208									p.G59E(3)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGACTCTTTTCCTTCCTCCAG	0.413000													9	106					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36468525	36468525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36468525C>T	ENST00000405275.2	+	13	1397	c.1154C>T	c.(1153-1155)gCt>gTt	p.A385V	CTNNBL1_ENST00000373469.1_Missense_Mutation_p.A160V|CTNNBL1_ENST00000373473.1_Missense_Mutation_p.A225V|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.A412V|CTNNBL1_ENST00000473857.1_3'UTR			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	412					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				TCGATCCTGGCTTCCCTCCTG	0.493000													18	47					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76397896	76397896	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76397896C>T	ENST00000357063.3	+	16	4252	c.2992C>T	c.(2992-2994)Caa>Taa	p.Q998*	LMO7_ENST00000377534.3_Nonsense_Mutation_p.Q998*|LMO7_ENST00000321797.8_Nonsense_Mutation_p.Q713*|LMO7_ENST00000526202.1_Nonsense_Mutation_p.Q563*|LMO7_ENST00000341547.4_Nonsense_Mutation_p.Q664*|LMO7_ENST00000465261.2_Nonsense_Mutation_p.Q713*			Q8WWI1	LMO7_HUMAN	LIM domain 7	998						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding	p.Q713K(1)|p.Q664K(1)|p.Q998K(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		ATCTCTTTCCCAAGACCAGGC	0.478000													25	59					0	0	1	0	0
HAUS5	23354	broad.mit.edu	37	19	36110939	36110939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36110939C>T	ENST00000203166.5	+	16	1457	c.1432C>T	c.(1432-1434)Cca>Tca	p.P478S	HAUS5_ENST00000379045.2_3'UTR	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	478					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						CACGGTCCTCCCATCCATCCA	0.672000													86	215					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212295675	212295675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:212295675C>T	ENST00000342788.4	-	21	2948	c.2638G>A	c.(2638-2640)Gga>Aga	p.G880R	ERBB4_ENST00000436443.1_Missense_Mutation_p.G880R|ERBB4_ENST00000402597.1_Missense_Mutation_p.G870R	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	880	Protein kinase.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CCCACCTTTCCTCCATCAGCA	0.363000										TSP Lung(8;0.080)			48	115					0	0	1	0	0
SYTL4	94121	broad.mit.edu	37	X	99934391	99934391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:99934391C>T	ENST00000455616.1	-	16	1923	c.1577G>A	c.(1576-1578)gGa>gAa	p.G526E	SYTL4_ENST00000263033.5_Missense_Mutation_p.G526E|SYTL4_ENST00000372989.1_Missense_Mutation_p.G526E|SYTL4_ENST00000454200.2_Missense_Mutation_p.G528E|SYTL4_ENST00000276141.6_Missense_Mutation_p.G526E			Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	526	C2 2.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(2)	27					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGGAGCTCTCCCCCTTCCCC	0.512000													31	14					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46898811	46898811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:46898811C>T	ENST00000378623.1	-	23	3458	c.3216G>A	c.(3214-3216)gtG>gtA	p.V1072V		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1072					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		TTGGTACCACCACATCAGCAA	0.527000													20	69					0	0	1	0	0
SOHLH2	54937	broad.mit.edu	37	13	36788653	36788653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36788653G>A	ENST00000379881.3	-	1	99	c.11C>T	c.(10-12)tCa>tTa	p.S4L	CCDC169-SOHLH2_ENST00000511166.1_Intron|SOHLH2_ENST00000317764.6_Missense_Mutation_p.S4L|SOHLH2_ENST00000554962.1_Intron	NM_017826.2	NP_060296.2			spermatogenesis and oogenesis specific basic helix-loop-helix 2											autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		GCAGATAATTGAGGAAGCCAT	0.667000													11	19					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151751698	151751698	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151751698G>A	ENST00000368822.1	-	5	1075	c.442C>T	c.(442-444)Cgt>Tgt	p.R148C	TDRKH_ENST00000440583.2_5'UTR|TDRKH_ENST00000458431.2_Missense_Mutation_p.R148C|TDRKH_ENST00000368823.1_Missense_Mutation_p.R144C|TDRKH_ENST00000368827.6_Missense_Mutation_p.R148C|TDRKH_ENST00000368825.3_Intron|TDRKH_ENST00000368824.3_Missense_Mutation_p.R148C|TDRKH_ENST00000484421.1_5'UTR			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	148	KH 2.						RNA binding	p.R148C(1)		breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CAGATAGAACGAATTGTCTCG	0.398000													23	75					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7311894	7311894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7311894C>T	ENST00000302926.2	+	1	393	c.320C>T	c.(319-321)cCg>cTg	p.P107L	NLGN2_ENST00000575301.1_Missense_Mutation_p.P107L	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	107					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				CCCGCCTGCCCGCAGAACCTG	0.741000													3	2					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125513025	125513025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125513025G>A	ENST00000373684.1	+	1	1007	c.1007G>A	c.(1006-1008)aGg>aAg	p.R336K	OR1L6_ENST00000304720.2_Missense_Mutation_p.R300K			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	336					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R336T(1)		breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						GATATGAAGAGGGGTTTGAAG	0.408000													21	42					0	0	1	0	0
TMEM133	83935	broad.mit.edu	37	11	100863138	100863138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100863138C>T	ENST00000303130.2	+	1	328	c.99C>T	c.(97-99)ccC>ccT	p.P33P		NM_032021.2	NP_114410.1	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	33						integral to membrane				kidney(2)|large_intestine(1)|lung(1)|prostate(1)	5		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		TTACTTTCCCCTTGACTAAAG	0.428000													32	98					0	0	1	0	0
KRT77	374454	broad.mit.edu	37	12	53096708	53096708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53096708G>A	ENST00000341809.3	-	1	539	c.511C>T	c.(511-513)Ctc>Ttc	p.L171F	KRT77_ENST00000537195.1_5'UTR	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	171	Coil 1A.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						ttgttgttgagaaccataatc	0.512000													45	131					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733505	152733505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152733505C>T	ENST00000368773.1	+	2	1499	c.1441C>T	c.(1441-1443)Ctg>Ttg	p.L481L	KPRP_ENST00000606109.1_Silent_p.L481L	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	481	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAATTCCCCTGCCGGCGCC	0.662000													52	103					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080123	54080123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54080123G>A	ENST00000253144.9	+	7	1642	c.309G>A	c.(307-309)atG>atA	p.M103I	ZNF331_ENST00000512387.1_Missense_Mutation_p.M103I|ZNF331_ENST00000511593.2_Missense_Mutation_p.M103I|ZNF331_ENST00000511154.1_Missense_Mutation_p.M103I|ZNF331_ENST00000449416.1_Missense_Mutation_p.M103I|ZNF331_ENST00000513265.1_Intron|ZNF331_ENST00000513999.1_Missense_Mutation_p.M103I|ZNF331_ENST00000411977.2_Missense_Mutation_p.M103I	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		TCAATCAGATGATCATCAATT	0.438000			T	?	follicular thyroid adenoma								25	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585180	179585180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179585180C>T	ENST00000589042.1	-	80	23533	c.23309G>A	c.(23308-23310)gGg>gAg	p.G7770E	TTN_ENST00000342992.6_Missense_Mutation_p.G6526E|TTN_ENST00000591111.1_Missense_Mutation_p.G7453E|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7453	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGATATTCCCCGACATCGGA	0.378000													38	105					0	0	1	0	0
PABPC1L	80336	broad.mit.edu	37	20	43541387	43541387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43541387C>T	ENST00000255136.3	+	2	362	c.280C>T	c.(280-282)Cgc>Tgc	p.R94C	PABPC1L_ENST00000217074.4_Missense_Mutation_p.R94C|PABPC1L_ENST00000217073.2_Missense_Mutation_p.R94C|PABPC1L_ENST00000537323.1_Missense_Mutation_p.R94C	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like	94							nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						CCCAGGACTTCGCAAGTCAGG	0.512000													16	77					0	0	1	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50474954	50474954	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50474954C>T	ENST00000602139.1	+	0	1029									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						GTGATGGTTTCCCAAGCAAAC	0.597000													30	97					0	0	1	0	0
HRH3	11255	broad.mit.edu	37	20	60791572	60791572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60791572C>T	ENST00000340177.5	-	3	1112	c.828G>A	c.(826-828)ggG>ggA	p.G276G	HRH3_ENST00000317393.6_Silent_p.G276G	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	276					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	CCTCACCCACCCCATACCTGT	0.756000													5	7					0	0	1	0	0
RASSF6	166824	broad.mit.edu	37	4	74477528	74477528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74477528G>A	ENST00000342081.3	-	2	211	c.81C>T	c.(79-81)ctC>ctT	p.L27L	RASSF6_ENST00000395777.2_5'UTR|RASSF6_ENST00000307439.5_5'UTR|RASSF6_ENST00000335049.5_Intron|RASSF6_ENST00000512591.1_5'UTR	NM_201431.2	NP_958834.1	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family member 6	27					apoptosis|signal transduction		protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|pancreas(2)|skin(2)	17	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CCTCCTTTTTGAGATGGTCTG	0.333000													45	103					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794788	140794788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140794788C>T	ENST00000398610.2	+	1	2046	c.2046C>T	c.(2044-2046)ttC>ttT	p.F682F	PCDHGA8_ENST00000398604.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB6_ENST00000520790.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGCAGCTTCGAGTCTCCAG	0.657000													57	137					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57425845	57425845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57425845C>T	ENST00000371237.4	-	2	163	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	C8B_ENST00000535057.1_5'UTR|C8B_ENST00000543257.1_5'UTR|C8B_ENST00000494324.1_5'UTR	NM_000066.2	NP_000057.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	33					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGTGGCCTTTCACCTCTAAAA	0.393000													26	76					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17157559	17157559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17157559C>T	ENST00000180173.5	-	14	1829	c.1795G>A	c.(1795-1797)Gaa>Aaa	p.E599K	MTMR7_ENST00000398099.3_Missense_Mutation_p.E190K|VPS37A_ENST00000521162.1_3'UTR	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	599							protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		GCAGAATCTTCATCGCCTTGT	0.483000													9	125					0	0	1	0	0
VWC2	375567	broad.mit.edu	37	7	49951682	49951682	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:49951682G>A	ENST00000340652.3	+	4	1435	c.879G>A	c.(877-879)aaG>aaA	p.K293K	ZPBP_ENST00000491129.1_Intron	NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	293					negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						GAGAAGTGAAGACTGACGAGT	0.453000													18	65					0	0	1	0	0
CD160	11126	broad.mit.edu	37	1	145698847	145698847	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145698847C>T	ENST00000369290.1	-	3	474	c.317G>A	c.(316-318)gGg>gAg	p.G106E	CD160_ENST00000369288.2_Intron|CD160_ENST00000235933.6_Intron|CD160_ENST00000401557.3_Intron			O95971	BY55_HUMAN	CD160 molecule	0	Ig-like V-type.				cell proliferation|cell surface receptor linked signaling pathway|cellular defense response|regulation of immune response	anchored to plasma membrane	MHC class I receptor activity|receptor binding			endometrium(3)|large_intestine(2)|lung(2)	7	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			TTTTTCTCTCCCCCTGGACAT	0.458000													4	6					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220501453	220501453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220501453C>T	ENST00000358055.3	+	16	2904	c.2392C>T	c.(2392-2394)Ctc>Ttc	p.L798F	SLC4A3_ENST00000373762.3_Missense_Mutation_p.L825F|SLC4A3_ENST00000273063.6_Missense_Mutation_p.L825F|SLC4A3_ENST00000373760.2_Missense_Mutation_p.L798F|SLC4A3_ENST00000317151.3_Missense_Mutation_p.L798F			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	798	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGGGTTGGTCTCTGGCTGGT	0.622000													38	87					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102469297	102469297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102469297C>T	ENST00000360184.4	+	23	5042	c.4878C>T	c.(4876-4878)ttC>ttT	p.F1626F		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	1626	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GGTCATCTTTCCCCAGGTAAG	0.463000													22	48					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228153893	228153893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228153893G>A	ENST00000396578.3	+	35	3071	c.2909G>A	c.(2908-2910)gGa>gAa	p.G970E	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	970	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGTGAGAAAGGAAACAGAGGC	0.483000													11	35					0	0	1	0	0
SULT1A2	6799	broad.mit.edu	37	16	28603583	28603583	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28603583C>T	ENST00000533150.1	-	3	1793		c.e3+1		SULT1A2_ENST00000335715.4_Splice_Site|SULT1A2_ENST00000395630.1_Splice_Site			P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2						3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|skin(2)	14						CCGGCACCTACCTTTCCTCAT	0.607000													24	111					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31682918	31682918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31682918C>T	ENST00000375483.3	+	10	1357	c.1357C>T	c.(1357-1359)Cct>Tct	p.P453S		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	453						cytoplasm|extracellular region	lipid binding										TGAAGAGCTTCCTCCACTTAC	0.488000													60	143					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48849077	48849077	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:48849077G>A	ENST00000314191.2	-	12	1170	c.1113_splice	c.e12-1	p.P372_splice	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Splice_Site_p.P372_splice	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	372					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACCTTGCACGGCTTTAGAAAA	0.378000								Non-homologous end-joining					18	38					0	0	1	0	0
FAM181A	90050	broad.mit.edu	37	14	94394743	94394743	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94394743C>T	ENST00000267594.5	+	3	605	c.298C>T	c.(298-300)Cgc>Tgc	p.R100C	FAM181A_ENST00000557000.2_Missense_Mutation_p.R38C|FAM181A_ENST00000557719.1_Missense_Mutation_p.R38C|FAM181A_ENST00000556222.1_Missense_Mutation_p.R38C	NM_001207073.1|NM_001207074.1|NM_138344.4	NP_001194002.1|NP_001194003.1|NP_612353.3	Q8N9Y4	F181A_HUMAN	family with sequence similarity 181, member A	100										cervix(1)|endometrium(2)|large_intestine(8)|lung(4)|prostate(1)|skin(2)	18						CGTGGACCATCGCAAGTACCT	0.612000													13	25					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55522958	55522958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:55522958C>T	ENST00000436346.1	-	31	6167	c.5326G>A	c.(5326-5328)Ggc>Agc	p.G1776S	CCDC88A_ENST00000422883.2_Missense_Mutation_p.G277S|CCDC88A_ENST00000263630.8_Missense_Mutation_p.G1748S|CCDC88A_ENST00000336838.6_Missense_Mutation_p.G1775S|CCDC88A_ENST00000413716.2_Intron	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1776					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						CCTTGAGTGCCTGGTGTAGGT	0.403000													23	65					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18770762	18770762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18770762C>T	ENST00000380548.4	+	17	2719	c.2380C>T	c.(2380-2382)Ctc>Ttc	p.L794F		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	794	TSP type-1 7.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CGAGTGGCTTCTCTCAGACTG	0.483000													14	17					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7812358	7812358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7812358G>A	ENST00000315599.7	-	1	62	c.40C>T	c.(40-42)Ctc>Ttc	p.L14F	CD209_ENST00000601951.1_5'UTR|CD209_ENST00000301357.8_Missense_Mutation_p.L14F|CD209_ENST00000315591.8_Missense_Mutation_p.L14F|CD209_ENST00000204801.8_Missense_Mutation_p.L14F|CD209_ENST00000602261.1_Missense_Mutation_p.L14F|CD209_ENST00000601256.1_5'UTR|CD209_ENST00000394161.5_Missense_Mutation_p.L14F|CD209_ENST00000593660.1_5'UTR|CD209_ENST00000354397.6_Missense_Mutation_p.L14F|CD209_ENST00000593821.1_Missense_Mutation_p.L14F|CD209_ENST00000394173.4_Missense_Mutation_p.L14F	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	14					cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TCACCCAGGAGGCCCAGCTGC	0.612000													96	221					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170118	58170118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58170118G>A	ENST00000309403.2	-	1	764	c.765C>T	c.(763-765)ttC>ttT	p.F255F		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTAAGTACATGAAGATAATAG	0.463000													18	81					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95941690	95941690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95941690G>A	ENST00000317620.9	+	3	440	c.307G>A	c.(307-309)Gag>Aag	p.E103K	PROM2_ENST00000542147.1_Missense_Mutation_p.E103K|PROM2_ENST00000317668.4_Missense_Mutation_p.E103K|PROM2_ENST00000403131.2_Missense_Mutation_p.E103K|PROM2_ENST00000463580.1_Intron	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	103						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						GGTGCGGTACGAGGCGGGCTA	0.687000													4	12					0	0	1	0	0
LVRN	206338	broad.mit.edu	37	5	115348125	115348125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:115348125C>T	ENST00000357872.4	+	15	2426	c.2302C>T	c.(2302-2304)Cgt>Tgt	p.R768C		NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		768					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										AACTATAATTCGTGAAAATGT	0.289000													39	134					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172025193	172025193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172025193G>A	ENST00000336824.4	+	10	1201	c.1102G>A	c.(1102-1104)Gag>Aag	p.E368K	FNDC3B_ENST00000416957.1_Missense_Mutation_p.E368K|FNDC3B_ENST00000415807.2_Missense_Mutation_p.E368K	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	368	Fibronectin type-III 1.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ATCCTGCTCCGAGCCTGTTAG	0.502000													30	89					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67815433	67815433	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67815433C>T	ENST00000265686.3	+	13	1656	c.1548C>T	c.(1546-1548)atC>atT	p.I516I	TCIRG1_ENST00000532635.1_Silent_p.I300I	NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	516					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity	p.I516I(1)		breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						CCTTTGGCATCGATCCTGTGA	0.647000													16	34					0	0	1	0	0
C1QTNF6	114904	broad.mit.edu	37	22	37578762	37578762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37578762G>A	ENST00000337843.2	-	3	378	c.303C>T	c.(301-303)gaC>gaT	p.D101D	C1QTNF6_ENST00000397110.2_Silent_p.D101D|C1QTNF6_ENST00000255836.6_Intron|RP1-151B14.6_ENST00000419128.1_RNA|C1QTNF6_ENST00000470655.1_Intron	NM_031910.3	NP_114116.3	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6	82	Collagen-like.					collagen				breast(1)|large_intestine(2)|lung(6)|stomach(1)|upper_aerodigestive_tract(1)	11						TTGGGCCTGGGTCCCCTTTGT	0.642000													14	20					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172163094	172163094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172163094G>A	ENST00000241256.2	-	2	1000	c.958C>T	c.(958-960)Ccc>Tcc	p.P320S		NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	320					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TACAGAATGGGGTTGATGGCA	0.502000													35	103					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14859437	14859437	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14859437G>A	ENST00000380881.4	-	5	1190	c.375C>T	c.(373-375)gtC>gtT	p.V125V	FREM1_ENST00000380880.3_Silent_p.V125V|FREM1_ENST00000422223.2_Silent_p.V125V			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	125					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCAGGAGATAGACCCACAGGA	0.403000													60	107					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72360523	72360523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72360523C>T	ENST00000441259.1	-	2	296	c.136G>A	c.(136-138)Gag>Aag	p.E46K	PRF1_ENST00000373209.2_Missense_Mutation_p.E46K	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	46	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						TCCACACCCTCCCCGGCCAGC	0.682000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				6	46					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107845226	107845226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:107845226G>A	ENST00000285311.3	-	4	1370	c.665C>T	c.(664-666)tCt>tTt	p.S222F	DKK2_ENST00000513208.1_Missense_Mutation_p.S122F|DKK2_ENST00000510463.1_Missense_Mutation_p.S176F	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	222	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space		p.S222F(1)|p.S222Y(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CAGCCCATGAGAACCCTTCTT	0.502000													45	128					0	0	1	0	0
CYP2F1	1572	broad.mit.edu	37	19	41628036	41628036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41628036G>A	ENST00000331105.2	+	6	892	c.820G>A	c.(820-822)Gag>Aag	p.E274K		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	274					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						CAAGATGGCAGAGGTAATCCC	0.602000													12	27					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169586315	169586315	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169586315C>T	ENST00000263686.6	-	3	469	c.432G>A	c.(430-432)aaG>aaA	p.K144K	SELP_ENST00000458599.2_Silent_p.K144K|SELP_ENST00000367792.2_Silent_p.K144K|SELP_ENST00000367794.2_Silent_p.K144K|SELP_ENST00000367786.2_Silent_p.K144K|SELP_ENST00000367791.2_Silent_p.K144K|SELP_ENST00000367788.2_Silent_p.K144K|SELP_ENST00000367793.2_Silent_p.K144K	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	144	C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CATCATTCCACTTGCCAGGGG	0.453000													49	145					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150931954	150931954	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:150931954G>A	ENST00000309170.3	-	3	463	c.151C>T	c.(151-153)Ccc>Tcc	p.P51S	P2RY14_ENST00000424796.2_Missense_Mutation_p.P51S|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	51						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTAGAGCTGGGCACGTAAAAG	0.438000													30	96					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33143334	33143334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:33143334C>T	ENST00000375030.2	+	22	2252	c.1634C>T	c.(1633-1635)tCg>tTg	p.S545L	C10orf68_ENST00000375028.3_Missense_Mutation_p.S590L|C10orf68_ENST00000375025.4_Missense_Mutation_p.S650L			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	586										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						TTAGGGCATTCGAAAGTTGTT	0.279000													13	38					0	0	1	0	0
DSCR4	10281	broad.mit.edu	37	21	39427006	39427006	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39427006G>A	ENST00000328264.3	-	3	404	c.300C>T	c.(298-300)ctC>ctT	p.L100L	DSCR4_ENST00000398948.1_Intron	NM_005867.2	NP_005858.1	P56555	DSCR4_HUMAN	Down syndrome critical region gene 4	100										large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	6						ATTTCTTGTGGAGCCCATGGA	0.463000													36	88					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372625	126372625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126372625C>T	ENST00000394329.3	+	9	10467	c.10454C>T	c.(10453-10455)tCa>tTa	p.S3485L	FAT4_ENST00000335110.5_Missense_Mutation_p.S1783L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3485	Cadherin 33.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCTGTTGATTCAGGGACCCCC	0.458000													59	146					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7984041	7984041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7984041G>A	ENST00000319144.4	-	5	845	c.585C>T	c.(583-585)ttC>ttT	p.F195F	AC129492.6_ENST00000399413.3_3'UTR	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	195	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						TTAAGTTCAGGAACTTGGTGG	0.577000										Multiple Myeloma(8;0.094)	OREG0024153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	75					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981621	70981621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70981621G>A	ENST00000276594.2	-	2	676	c.475C>T	c.(475-477)Ctg>Ttg	p.L159L		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TCAGGTAACAGAGAAGCATCC	0.562000													8	52					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71978050	71978050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71978050G>A	ENST00000266674.5	+	18	2571	c.2260G>A	c.(2260-2262)Gga>Aga	p.G754R	LGR5_ENST00000540815.2_Missense_Mutation_p.G730R|LGR5_ENST00000536515.1_Missense_Mutation_p.G682R			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	754						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TTTGGACAAGGGAGACCTGGA	0.483000													19	129					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382697	22382697	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22382697C>T	ENST00000328795.4	+	1	316	c.225C>T	c.(223-225)ttC>ttT	p.F75F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCTACTCCTTCATTGTGGCTC	0.478000													56	233					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35648033	35648033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:35648033C>T	ENST00000287272.2	+	16	2627	c.2607C>T	c.(2605-2607)tcC>tcT	p.S869S	UNC5D_ENST00000416672.1_Silent_p.S943S|UNC5D_ENST00000420357.1_Silent_p.S871S|UNC5D_ENST00000404895.2_Silent_p.S938S|UNC5D_ENST00000453357.2_Silent_p.S933S|UNC5D_ENST00000449677.1_Silent_p.S514S			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	938	Death.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTTCAGAATCCCAGCTTGATG	0.502000													20	50					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90052277	90052277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90052277C>T	ENST00000405460.2	+	56	11683	c.11587C>T	c.(11587-11589)Ctt>Ttt	p.L3863F		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3863	Calx-beta 25.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCAGGATGACCTTCCTGAATT	0.408000													44	109					0	0	1	0	0
PAGE4	9506	broad.mit.edu	37	X	49597218	49597218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:49597218C>T	ENST00000218068.6	+	4	336	c.257C>T	c.(256-258)cCa>cTa	p.P86L	PAGE4_ENST00000376141.1_Missense_Mutation_p.P86L	NM_007003.2	NP_008934.1	O60829	GAGC1_HUMAN	P antigen family, member 4 (prostate associated)	86												Ovarian(276;0.236)					GAGAAGACTCCACCTAATCCT	0.383000													20	30					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47228830	47228830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47228830G>A	ENST00000391910.3	-	10	1795	c.1345C>T	c.(1345-1347)Cgt>Tgt	p.R449C	STRN4_ENST00000263280.6_Missense_Mutation_p.R442C|STRN4_ENST00000539396.1_Missense_Mutation_p.R323C|STRN4_ENST00000594357.2_5'UTR			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	442						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding	p.R442C(1)		NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GCCAGGGAACGAATGCCGTCG	0.612000													13	44					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332927	70332927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70332927G>A	ENST00000338508.4	-	32	3473	c.3474C>T	c.(3472-3474)ttC>ttT	p.F1158F	SHANK2_ENST00000423696.2_Silent_p.F778F|SHANK2_ENST00000409161.1_Silent_p.F561F|SHANK2_ENST00000449833.2_Silent_p.F562F			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	778					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding	p.F1158F(1)|p.F562F(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CGCCACCCACGAAATGGTTTT	0.672000													29	69					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104067702	104067702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104067702G>A	ENST00000388887.2	+	23	2593	c.2389G>A	c.(2389-2391)Gga>Aga	p.G797R		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	797					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTGCGTTCACGGAACATGCAA	0.592000													12	47					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5058617	5058617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:5058617C>T	ENST00000251170.7	+	14	1948	c.1768C>T	c.(1768-1770)Ccc>Tcc	p.P590S		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	590	GOLD.					integral to membrane|intracellular	transporter activity	p.P590A(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						TGTGGAGGCTCCCCTTGTCTG	0.657000													26	70					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	76955545	76955545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76955545C>T	ENST00000257626.7	-	23	1889	c.1811G>A	c.(1810-1812)cGg>cAg	p.R604Q	GSAP_ENST00000441833.2_5'UTR|GSAP_ENST00000440473.1_5'UTR	NM_017439.3	NP_059135.2			gamma-secretase activating protein																		CATGAGCAGCCGCTGGTGGCT	0.512000													23	69					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039138	11039138	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039138G>A	ENST00000470054.1	-	0	1065									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGGACATAATGAAGTGCTTTC	0.403000													48	550					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45281402	45281402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45281402G>A	ENST00000270279.3	+	1	277	c.214G>A	c.(214-216)Ggt>Agt	p.G72S	CBLC_ENST00000341505.4_Missense_Mutation_p.G72S	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	72	4H.|Cbl-PTB.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				cggccccgggggtcccggcgg	0.726000			M		AML								8	6					0	0	1	0	0
RASEF	158158	broad.mit.edu	37	9	85622405	85622405	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:85622405G>A	ENST00000376447.3	-	7	1235	c.975C>T	c.(973-975)atC>atT	p.I325I		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	325					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TGTATGCTCGGATTATTTCCA	0.398000													47	69					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74364582	74364582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74364582C>T	ENST00000290438.3	-	14	1610	c.1570G>A	c.(1570-1572)Gac>Aac	p.D524N		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	524										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						CTCTCCAGGTCCTCTGGGATG	0.627000													10	176					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65239505	65239505	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65239505G>A	ENST00000389722.3	-	25	5399	c.5346C>T	c.(5344-5346)ctC>ctT	p.L1782L	SPTB_ENST00000556626.1_Silent_p.L1782L|SPTB_ENST00000542895.1_Silent_p.L1782L|SPTB_ENST00000389721.5_Silent_p.L1782L|SPTB_ENST00000389720.3_Silent_p.L1782L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1782					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGAGCTCCAGGAGGTCTGCCC	0.627000													26	39					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231233	21231233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21231233C>T	ENST00000233242.1	-	26	8634	c.8507G>A	c.(8506-8508)aGa>aAa	p.R2836K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2836					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGCTCCGTTCTCAGGTACTT	0.408000													54	163					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6442295	6442295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6442295G>A	ENST00000162749.2	-	5	790	c.491C>T	c.(490-492)aCc>aTc	p.T164I	TNFRSF1A_ENST00000366159.4_Missense_Mutation_p.T164I|TNFRSF1A_ENST00000540022.1_Missense_Mutation_p.T121I|TNFRSF1A_ENST00000437813.3_5'UTR	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	164					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						GGTGCACACGGTGTTCTGTTT	0.557000													9	32					0	0	1	0	0
IGHV1-18	28468	broad.mit.edu	37	14	106641605	106641605	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106641605C>T	ENST00000390605.2	-	0	367																											ATCTCAGGCTCCTCAGCTCCA	0.537000													120	228					0	0	1	0	0
ASB17	127247	broad.mit.edu	37	1	76397716	76397716	+	Silent	SNP	G	G	A	rs11811988		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:76397716G>A	ENST00000284142.6	-	1	400	c.261C>T	c.(259-261)ctC>ctT	p.L87L		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	87					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						CAGTGAAGTCGAGGTTAAAAC	0.378000													7	68					0	0	1	0	0
PRH2	5555	broad.mit.edu	37	12	11083393	11083393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11083393G>A	ENST00000396400.3	+	3	271	c.233G>A	c.(232-234)gGc>gAc	p.G78D	PRH2_ENST00000381847.3_Missense_Mutation_p.G78D|PRR4_ENST00000536668.1_Intron	NM_001110213.1	NP_001103683.1	P02810	PRPC_HUMAN	proline-rich protein HaeIII subfamily 2	78						extracellular space	protein binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	13						CAACAAGGAGGCCAGCAGCAA	0.607000													24	79					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363937	22363937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22363937C>T	ENST00000397121.2	-	3	899	c.582G>A	c.(580-582)gaG>gaA	p.E194E		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TGTAGGGTTTCTCTCCAGTAT	0.348000													10	110					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104705146	104705146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104705146C>T	ENST00000526691.1	+	3	655	c.199C>T	c.(199-201)Ctt>Ttt	p.L67F	TXNRD1_ENST00000526950.1_Missense_Mutation_p.L84F|TXNRD1_ENST00000529546.1_Intron|TXNRD1_ENST00000542918.1_Missense_Mutation_p.L65F|TXNRD1_ENST00000388854.3_Missense_Mutation_p.L67F|TXNRD1_ENST00000525566.1_Missense_Mutation_p.L165F|TXNRD1_ENST00000526390.1_Missense_Mutation_p.L59F|TXNRD1_ENST00000503506.2_Missense_Mutation_p.L15F|TXNRD1_ENST00000429002.2_Missense_Mutation_p.L165F|TXNRD1_ENST00000427956.1_Missense_Mutation_p.L130F|TXNRD1_ENST00000397736.2_Missense_Mutation_p.L59F|TXNRD1_ENST00000524698.1_Missense_Mutation_p.L15F|TXNRD1_ENST00000378070.4_Missense_Mutation_p.L114F|TXNRD1_ENST00000540716.1_Intron|TXNRD1_ENST00000354940.6_Missense_Mutation_p.L15F	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	165	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						TGACTATGACCTTATCATCAT	0.443000													3	20					0	0	1	0	0
PLAUR	5329	broad.mit.edu	37	19	44171764	44171764	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44171764G>A	ENST00000221264.4	-	2	561	c.135C>T	c.(133-135)ctC>ctT	p.L45L	PLAUR_ENST00000340093.3_Silent_p.L45L|PLAUR_ENST00000339082.3_Silent_p.L45L|PLAUR_ENST00000601723.1_Silent_p.L45L	NM_001005377.2	NP_001005377.1	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	45	UPAR/Ly6 1.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(1)|stomach(1)|urinary_tract(3)	20		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	TGGTCCTGCAGAGGTCCTGTC	0.622000													20	50					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111239	7111239	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7111239G>A	ENST00000306904.5	+	1	1075	c.888G>A	c.(886-888)cgG>cgA	p.R296R		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	296	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCCCAGGACGGGGGACACCGC	0.662000													13	29					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38137471	38137471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:38137471C>T	ENST00000379747.4	-	23	2627	c.2510G>A	c.(2509-2511)tGa>tAa	p.*837*	POSTN_ENST00000379749.4_Silent_p.*809*|POSTN_ENST00000541481.1_Silent_p.*750*|POSTN_ENST00000541179.1_Silent_p.*782*|POSTN_ENST00000379743.4_Silent_p.*810*|POSTN_ENST00000379742.4_Silent_p.*780*	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	0					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TTTGGATTTTCACTGAGAACG	0.323000													21	41					0	0	1	0	0
VCX3B	425054	broad.mit.edu	37	X	8434313	8434313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:8434313G>A	ENST00000381032.1	+	3	937	c.630G>A	c.(628-630)atG>atA	p.M210I	VCX3B_ENST00000381029.4_Missense_Mutation_p.M178I|VCX3B_ENST00000444481.1_Missense_Mutation_p.M180I|VCX3B_ENST00000440654.2_Missense_Mutation_p.M160I|VCX3B_ENST00000453306.1_Intron	NM_001001888.3	NP_001001888.3	Q9H321	VCX3B_HUMAN	variable charge, X-linked 3B	210	11 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.					nucleolus				NS(1)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|urinary_tract(3)	11						AGAGCGAGATGGAAGAACCAC	0.562000													41	195					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156915384	156915384	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156915384C>T	ENST00000257527.4	-	21	2517	c.2439G>A	c.(2437-2439)agG>agA	p.R813R	ADAM19_ENST00000430702.2_Silent_p.R546R|ADAM19_ENST00000517905.1_Silent_p.R813R|ADAM19_ENST00000394020.1_Silent_p.R815R	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	813					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCCTAGCAGCCCTGCTCAGGT	0.652000													35	79					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189875434	189875434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189875434C>T	ENST00000304636.3	+	50	4242	c.4072C>T	c.(4072-4074)Cga>Tga	p.R1358*	COL3A1_ENST00000317840.5_Nonsense_Mutation_p.R1055*	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1358	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGCATTCCTTCGACTTCTCTC	0.428000													26	115					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974693	49974693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:49974693C>T	ENST00000555099.1	+	1	751	c.719C>T	c.(718-720)tCc>tTc	p.S240F		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						ACCTGTGTCTCCCACATCACA	0.458000													59	85					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100148243	100148243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:100148243G>A	ENST00000370575.4	-	13	1363	c.1315C>T	c.(1315-1317)Cct>Tct	p.P439S	PYROXD2_ENST00000483923.1_Intron	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	439							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						AGCGAGGAAGGGATGCAGAGC	0.622000													8	13					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32371624	32371624	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32371624C>T	ENST00000375200.1	+	12	2171	c.1806C>T	c.(1804-1806)ttC>ttT	p.F602F	ZNF341_ENST00000342427.2_Silent_p.F595F			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	602					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GCAAGAAGTTCTTCCGGCGGG	0.617000													12	65					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43039079	43039079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43039079C>T	ENST00000394056.2	+	10	1717	c.1222C>T	c.(1222-1224)Cgt>Tgt	p.R408C	KLC4_ENST00000479388.1_Missense_Mutation_p.R408C|KLC4_ENST00000259708.3_Missense_Mutation_p.R426C|KLC4_ENST00000394058.1_Missense_Mutation_p.R408C|KLC4_ENST00000453940.2_Missense_Mutation_p.R331C|KLC4_ENST00000347162.5_Missense_Mutation_p.R408C			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	408						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			GATCCTGACCCGTGCCCATGT	0.512000													16	43					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169141144	169141144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169141144G>A	ENST00000256935.8	+	18	1852	c.1772G>A	c.(1771-1773)gGg>gAg	p.G591E	DOCK2_ENST00000540750.1_5'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.G83E	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	591	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTGTTGGGGGGCTTTCTGTC	0.542000													22	49					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49165917	49165917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49165917G>A	ENST00000418109.1	-	16	2156	c.1992C>T	c.(1990-1992)atC>atT	p.I664I	LAMB2_ENST00000305544.4_Silent_p.I664I	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	664	Laminin IV type B.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAGTCCCTTGGATGCGATCAT	0.612000													10	36					0	0	1	0	0
RNF182	221687	broad.mit.edu	37	6	13977612	13977612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13977612C>T	ENST00000488300.1	+	3	785	c.262C>T	c.(262-264)Ctt>Ttt	p.L88F	RNF182_ENST00000537388.1_Missense_Mutation_p.L88F|RNF182_ENST00000537663.1_Missense_Mutation_p.L88F|RNF182_ENST00000544682.1_Missense_Mutation_p.L88F	NM_152737.3	NP_689950.1	Q8N6D2	RN182_HUMAN	ring finger protein 182	88						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|large_intestine(7)|liver(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			CAACAACATCCTTGTAAACTT	0.542000													36	89					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128642808	128642808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128642808G>A	ENST00000344954.6	+	4	806	c.418G>A	c.(418-420)Gag>Aag	p.E140K	FLI1_ENST00000429175.2_Missense_Mutation_p.E173K|FLI1_ENST00000525560.1_Intron|FLI1_ENST00000281428.8_Missense_Mutation_p.E107K|FLI1_ENST00000534087.1_Missense_Mutation_p.E140K			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	173	PNT.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		AATGAACAAGGAGGACTTCCT	0.522000			T	EWSR1	Ewing sarcoma								47	141					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47601016	47601016	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:47601016G>A	ENST00000439988.2	-	5	618	c.619C>T	c.(619-621)Cga>Tga	p.R207*	MDGA2_ENST00000357362.3_5'UTR|MDGA2_ENST00000426342.1_5'UTR|MDGA2_ENST00000399232.2_Nonsense_Mutation_p.R276*			Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	207	Ig-like 2.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						TCCTGAGGTCGAAGATTCTTT	0.343000													19	44					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20559433	20559433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20559433C>T	ENST00000329697.6	-	8	1217	c.1049G>A	c.(1048-1050)aGg>aAg	p.R350K	ACSM2B_ENST00000565322.1_Missense_Mutation_p.R271K|ACSM2B_ENST00000567001.1_Missense_Mutation_p.R350K|ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565232.1_Missense_Mutation_p.R350K	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	350					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TGTCTGGGCCCTCCAGTTCTC	0.512000													45	205					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38357818	38357818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38357818G>A	ENST00000273173.4	+	9	1627	c.1536G>A	c.(1534-1536)gcG>gcA	p.A512A	SLC22A14_ENST00000448498.1_Silent_p.A512A	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	512			A -> V (in dbSNP:rs2070492).			integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CTTTCAGGGCGACAGGTCTGG	0.612000													17	59					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26839553	26839553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:26839553G>A	ENST00000381340.3	-	11	1425	c.1009C>T	c.(1009-1011)Cct>Tct	p.P337S		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	337	MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GAAGTTGGAGGGACTCCATCT	0.398000													35	177					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184580816	184580816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184580816C>T	ENST00000287546.4	+	15	1527	c.1356C>T	c.(1354-1356)ttC>ttT	p.F452F	VPS8_ENST00000436792.2_Silent_p.F450F|VPS8_ENST00000446204.2_Silent_p.F450F|VPS8_ENST00000437079.3_Silent_p.F452F	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	452							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GCAGCCATTTCAAATCACTAG	0.408000													59	121					0	0	1	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315572	73315572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73315572G>A	ENST00000258098.6	-	3	1414	c.1174C>T	c.(1174-1176)Cgt>Tgt	p.R392C	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	392					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						CTGTTGCTACGACTGCCTCTG	0.637000													21	74					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53225270	53225270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53225270C>T	ENST00000330553.5	-	2	652	c.618G>A	c.(616-618)ctG>ctA	p.L206L		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	206	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GAAGTCTGTCCAGCGTGCTCC	0.612000													32	105					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2024083	2024083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2024083C>T	ENST00000568546.1	+	2	196	c.68C>T	c.(67-69)cCt>cTt	p.P23L		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	23					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						AAAATTGAGCCTTTCTACAAG	0.652000													8	34					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46930315	46930315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46930315C>T	ENST00000264318.3	-	9	2574	c.1592G>A	c.(1591-1593)gGg>gAg	p.G531E		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	531					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.G531V(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTTAAATGCCCCAAATGTGAC	0.388000													23	100					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99509613	99509613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:99509613C>T	ENST00000261037.3	+	4	467	c.87C>T	c.(85-87)gcC>gcT	p.A29A	COL8A1_ENST00000273342.4_Silent_p.A29A	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	29	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						AGGCTGGTGCCTACTATGGGA	0.562000													26	42					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39226715	39226715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39226715G>A	ENST00000340369.3	-	2	4450	c.4222C>T	c.(4222-4224)Ccc>Tcc	p.P1408S	XIRP1_ENST00000421646.1_Missense_Mutation_p.P91S|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1408							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTGGGCCTGGGGGCCGTGGTG	0.602000													22	54					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61835772	61835772	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61835772G>A	ENST00000280772.1	-	37	5058	c.4867C>T	c.(4867-4869)Cga>Tga	p.R1623*	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1623	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGAGAGGTTCGAGAGGAAAAC	0.478000													30	89					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99944898	99944898	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:99944898G>A	ENST00000524871.1	+	13	1742	c.1452G>A	c.(1450-1452)ctG>ctA	p.L484L	CNTN5_ENST00000527185.1_Silent_p.L484L|CNTN5_ENST00000528682.1_Silent_p.L484L|CNTN5_ENST00000279463.3_Silent_p.L484L|CNTN5_ENST00000418526.2_Silent_p.L410L	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	484	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding	p.L484L(2)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTTTTGCACTGAATCAACTGA	0.373000													5	34					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157929367	157929367	+	Missense_Mutation	SNP	C	C	T	rs142423725		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157929367C>T	ENST00000389413.3	-	8	1256	c.1153G>A	c.(1153-1155)Gat>Aat	p.D385N	PTPRN2_ENST00000409483.1_Missense_Mutation_p.D347N|PTPRN2_ENST00000404321.2_Missense_Mutation_p.D408N|PTPRN2_ENST00000389416.4_Missense_Mutation_p.D368N|PTPRN2_ENST00000389418.4_Missense_Mutation_p.D385N	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	385						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGTCTATCATCGTCGTCCTGC	0.433000													10	100					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532391	50532391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50532391C>T	ENST00000374144.3	+	3	2089	c.1801C>T	c.(1801-1803)Ccc>Tcc	p.P601S	C10orf71_ENST00000323868.4_Missense_Mutation_p.P601S			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	601										endometrium(1)	1						CGCCAAAGCCCCCTTCTATGT	0.547000													10	23					0	0	1	0	0
OSBPL6	114880	broad.mit.edu	37	2	179255882	179255882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179255882G>A	ENST00000190611.4	+	22	2760	c.2384G>A	c.(2383-2385)gGa>gAa	p.G795E	OSBPL6_ENST00000409631.1_Missense_Mutation_p.G759E|OSBPL6_ENST00000392505.2_Missense_Mutation_p.G820E|OSBPL6_ENST00000359685.3_Missense_Mutation_p.G759E|OSBPL6_ENST00000409045.3_Missense_Mutation_p.G764E|OSBPL6_ENST00000315022.2_Missense_Mutation_p.G799E	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	795					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CGGCTGTTTGGAAAGTGGCAT	0.527000													41	117					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10033879	10033879	+	Missense_Mutation	SNP	C	C	T	rs150596900		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:10033879C>T	ENST00000378380.3	+	8	2319	c.1990C>T	c.(1990-1992)Cct>Tct	p.P664S	ANKEF1_ENST00000488991.1_3'UTR|ANKEF1_ENST00000378392.1_Missense_Mutation_p.P664S|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000603542.1_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		AGGCAAGACACCTCCTATACT	0.348000													21	113					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51224954	51224954	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51224954G>A	ENST00000245441.5	-	18	2984	c.2794C>T	c.(2794-2796)Ctg>Ttg	p.L932L	NIN_ENST00000530997.2_Silent_p.L932L|NIN_ENST00000453196.1_Silent_p.L932L|NIN_ENST00000382041.3_Silent_p.L932L|NIN_ENST00000324330.9_Silent_p.L932L|NIN_ENST00000389868.3_Intron|NIN_ENST00000382043.4_Intron	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	932					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TCAGACAGCAGGCTTTGCTGG	0.517000			T	PDGFRB	MPD								49	124					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52812419	52812419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52812419C>T	ENST00000273283.2	+	3	226	c.202C>T	c.(202-204)Cac>Tac	p.H68Y	ITIH1_ENST00000542827.1_Missense_Mutation_p.H68Y	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	68	VIT.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TCGCTTCGCCCACTATGTTGT	0.522000													48	98					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55525834	55525834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55525834C>T	ENST00000219070.4	+	8	1811	c.1302C>T	c.(1300-1302)tcC>tcT	p.S434S	MMP2_ENST00000437642.2_Silent_p.S384S|MMP2_ENST00000570308.1_Silent_p.S358S|MMP2_ENST00000543485.1_Silent_p.S358S	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	434	Collagenase-like 2.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	TCCGTCTGTCCCAGGATGACA	0.617000													13	31					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94935629	94935629	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94935629G>A	ENST00000337425.5	-	2	677	c.603C>T	c.(601-603)acC>acT	p.T201T	SERPINA9_ENST00000448305.2_Silent_p.T103T|SERPINA9_ENST00000424550.2_Silent_p.T52T|SERPINA9_ENST00000546329.1_Silent_p.T165T|SERPINA9_ENST00000380365.3_Silent_p.T183T|SERPINA9_ENST00000298845.7_Silent_p.T101T	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	183					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CCTTCCCTTGGGTCTTCTTTT	0.453000													58	174					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116605158	116605158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116605158C>T	ENST00000369248.4	+	8	1381	c.1046C>T	c.(1045-1047)tCa>tTa	p.S349L	FAM160B1_ENST00000369250.3_Missense_Mutation_p.S349L	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	349										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						GAAGATGCTTCAGCATTTCCA	0.358000													28	68					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46787167	46787167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46787167G>A	ENST00000262738.3	-	16	6165	c.6166C>T	c.(6166-6168)Ccc>Tcc	p.P2056S		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2056					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AATGCTTTGGGACAGCCATTG	0.617000											OREG0026656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	27					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178854323	178854323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:178854323G>A	ENST00000367635.3	+	12	1355	c.1017G>A	c.(1015-1017)agG>agA	p.R339R	RALGPS2_ENST00000477383.1_3'UTR|RALGPS2_ENST00000367634.2_Silent_p.R339R|RALGPS2_ENST00000324778.4_Silent_p.R304R	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	339					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						ATGGACATAGGAAGTGCCATA	0.408000													12	70					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8651597	8651597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8651597C>T	ENST00000270328.4	-	19	2514	c.2248G>A	c.(2248-2250)Gga>Aga	p.G750R	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.G750R|ADAMTS10_ENST00000595838.1_Missense_Mutation_p.G237R			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	750	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TCCTGGTCTCCCTTCAGGGCT	0.637000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	87					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52258422	52258422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:52258422C>T	ENST00000356297.4	-	20	4087	c.3987G>A	c.(3985-3987)aaG>aaA	p.K1329K	PXDNL_ENST00000543296.1_Intron	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1329					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ACTCCATATCCTTATCAACAG	0.378000													14	51					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116858707	116858707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116858707C>T	ENST00000374118.3	-	5	521	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	KIF12_ENST00000473174.1_5'UTR	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	228	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						GGCATGGCTTCGGCTGGAGGC	0.582000													6	11					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411707	23411707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23411707G>A	ENST00000379361.4	+	3	2932	c.2072G>A	c.(2071-2073)cGa>cAa	p.R691Q		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	691					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TACATGGATCGATATGCCTCC	0.488000													33	21					0	0	1	0	0
AADAC	13	broad.mit.edu	37	3	151545475	151545475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151545475C>T	ENST00000232892.6	+	5	841	c.715C>T	c.(715-717)Cta>Tta	p.L239L	RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	239					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TTCAAATTTTCTATTTCTATC	0.368000													34	71					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43230915	43230915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43230915G>A	ENST00000259750.4	+	13	1896	c.1813G>A	c.(1813-1815)Gag>Aag	p.E605K	TTBK1_ENST00000304139.5_Missense_Mutation_p.E554K	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	605						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGCGCTGGCGGAGGAGGACCT	0.756000													3	7					0	0	1	0	0
SLC25A41	284427	broad.mit.edu	37	19	6433541	6433541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6433541C>T	ENST00000321510.6	-	1	232	c.164G>A	c.(163-165)gGc>gAc	p.G55D		NM_173637.3	NP_775908.2	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	55					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	6						ATGCATGTGGCCAAACGCGTA	0.582000													23	74					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41181646	41181646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41181646C>T	ENST00000263413.3	-	7	1006	c.742G>A	c.(742-744)Gat>Aat	p.D248N	C6_ENST00000337836.5_Missense_Mutation_p.D248N|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	248	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding	p.D248Y(1)		central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTCAAGTCATCTTCTGCAGTT	0.348000													14	53					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21557827	21557827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:21557827G>A	ENST00000382592.4	-	5	2423	c.2018C>T	c.(2017-2019)aCc>aTc	p.T673I	LATS2_ENST00000542899.1_Missense_Mutation_p.T673I	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	673	Protein kinase.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		GATCCCCAGGGTTTTGATCTT	0.488000													45	110					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69327560	69327560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69327560G>A	ENST00000305363.4	+	2	97	c.33G>A	c.(31-33)agG>agA	p.R11R		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	11					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TGAGGGCTAGGAAAAGAGTTT	0.428000													143	347					0	0	1	0	0
ZNRF3	84133	broad.mit.edu	37	22	29446228	29446228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29446228C>T	ENST00000544604.2	+	8	2234	c.2059C>T	c.(2059-2061)Ctc>Ttc	p.L687F	ZNRF3_ENST00000406323.3_Missense_Mutation_p.L587F|ZNRF3_ENST00000332811.4_Missense_Mutation_p.L587F|ZNRF3_ENST00000402174.1_Missense_Mutation_p.L587F	NM_001206998.1	NP_001193927.1	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	687						integral to membrane	zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(4)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	28						AGAAGTGGGGCTCGAGGCTTC	0.667000													8	73					0	0	1	0	0
FCGR2B	2213	broad.mit.edu	37	1	161641278	161641278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161641278C>T	ENST00000367962.4	+	3	357	c.230C>T	c.(229-231)cCt>cTt	p.P77L	FCGR2B_ENST00000403078.3_Missense_Mutation_p.P77L|FCGR2B_ENST00000367960.5_Missense_Mutation_p.P70L|FCGR2B_ENST00000236937.9_Missense_Mutation_p.P77L|FCGR2B_ENST00000428605.2_Missense_Mutation_p.P77L|FCGR2B_ENST00000358671.5_Missense_Mutation_p.P77L|FCGR2B_ENST00000367961.4_Missense_Mutation_p.P70L			P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor (CD32)	77	Ig-like C2-type 1.				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity					all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACTCACAGCCCTGAGAGCGAC	0.582000			T	?	ALL								18	77					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31533829	31533829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31533829C>T	ENST00000215885.3	-	4	1185	c.933G>A	c.(931-933)ggG>ggA	p.G311G		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	311					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						GATGTGGTGGCCCCTTCCGAA	0.652000													61	139					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169394126	169394126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169394126C>T	ENST00000545005.1	-	3	547	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	CCDC181_ENST00000367805.3_Missense_Mutation_p.E14K|CCDC181_ENST00000491570.1_5'UTR|CCDC181_ENST00000367806.3_Missense_Mutation_p.E14K					coiled-coil domain containing 181																		TCTTCGTATTCTTCACTTTTC	0.308000													25	62					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773898	140773898	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140773898C>T	ENST00000398604.2	+	1	1518	c.1518C>T	c.(1516-1518)tcC>tcT	p.S506S	PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTATATCTCCATCAACTCTG	0.592000													8	83					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160465879	160465879	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160465879C>T	ENST00000368059.3	-	2	423	c.354G>A	c.(352-354)aaG>aaA	p.K118K	SLAMF6_ENST00000368055.1_Intron|SLAMF6_ENST00000368057.3_Silent_p.K118K	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	118						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			AACTGGACAGCTTTGCAGAGG	0.423000													56	129					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634749	70634749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70634749C>T	ENST00000381269.2	-	2	1144	c.391G>A	c.(391-393)Gaa>Aaa	p.E131K	SLC8A3_ENST00000528359.1_Missense_Mutation_p.E131K|SLC8A3_ENST00000357887.3_Missense_Mutation_p.E131K|SLC8A3_ENST00000534137.1_Missense_Mutation_p.E131K|SLC8A3_ENST00000356921.2_Missense_Mutation_p.E131K	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	131					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GAGACAGTTTCATTCCAGACC	0.478000													29	44					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83636688	83636688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:83636688G>A	ENST00000265362.3	-	10	1435	c.1121C>T	c.(1120-1122)cCc>cTc	p.P374L	SEMA3A_ENST00000436949.1_Missense_Mutation_p.P374L	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	374	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CCGTGGATAGGGGACTCTTCC	0.423000													44	112					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51757907	51757907	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51757907G>A	ENST00000543196.2	-	5	1252	c.1047C>T	c.(1045-1047)atC>atT	p.I349I	GALNT6_ENST00000356317.3_Silent_p.I349I			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	349	Catalytic subdomain B.				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						GTCCTTACTTGATGGGGTAGG	0.552000													32	55					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55272965	55272965	+	Silent	SNP	C	C	T	rs143770509		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55272965C>T	ENST00000275493.2	+	28	3465	c.3288C>T	c.(3286-3288)tcC>tcT	p.S1096S	EGFR_ENST00000454757.2_Silent_p.S1043S|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	1096					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TAAACCAGTCCGTTCCCAAAA	0.527000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			11	43					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99640764	99640764	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:99640764C>T	ENST00000345514.2	-	3	2462	c.2196G>A	c.(2194-2196)aaG>aaA	p.K732K	BCL11B_ENST00000357195.3_Silent_p.K803K|BCL11B_ENST00000443726.2_Silent_p.K609K	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	803						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		TCTTGAACACCTTGCCGCAGT	0.711000			T	TLX3	T-ALL								4	19					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233393629	233393629	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233393629G>T	ENST00000258385.3	+	6	599	c.567G>T	c.(565-567)gaG>gaT	p.E189D	CHRND_ENST00000457943.2_Intron|CHRND_ENST00000536614.1_Intron|CHRND_ENST00000543200.1_Missense_Mutation_p.E174D	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	189					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		ATGCCAAGGAGAACCGCACCT	0.587000													15	94					0.00316338	0.00316555	1	1	0
ARHGEF10L	55160	broad.mit.edu	37	1	17953868	17953868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17953868C>T	ENST00000361221.3	+	15	1613	c.1454C>T	c.(1453-1455)tCg>tTg	p.S485L	ARHGEF10L_ENST00000375420.3_Missense_Mutation_p.S243L|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000452522.1_Missense_Mutation_p.S446L|ARHGEF10L_ENST00000375415.1_Missense_Mutation_p.S446L|ARHGEF10L_ENST00000375408.3_Missense_Mutation_p.S263L|ARHGEF10L_ENST00000434513.1_Missense_Mutation_p.S485L|ARHGEF10L_ENST00000167825.4_Missense_Mutation_p.S193L	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	485	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GACAGGCTGTCGCTGCAGCTG	0.627000													18	60					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6087174	6087174	+	Silent	SNP	C	C	T	rs61753516		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6087174C>T	ENST00000409021.3	-	4	1256	c.807G>A	c.(805-807)ggG>ggA	p.G269G	JAKMIP1_ENST00000410077.2_Silent_p.G104G|JAKMIP1_ENST00000409831.1_Silent_p.G269G|JAKMIP1_ENST00000409371.3_Silent_p.G104G|JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000282924.5_Silent_p.G269G	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	269	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCACCATGTCCCCGATCCCGG	0.607000													11	41					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46312191	46312191	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:46312191G>A	ENST00000510861.1	-	6	731	c.559_splice	c.e6+1	p.S186_splice	GABRA2_ENST00000381620.4_Splice_Site_p.S186_splice|GABRA2_ENST00000507069.1_Splice_Site_p.S186_splice|GABRA2_ENST00000356504.1_Splice_Site_p.S186_splice|GABRA2_ENST00000514090.1_Splice_Site_p.S186_splice|GABRA2_ENST00000515082.1_Splice_Site_p.S186_splice|GABRA2_ENST00000540012.1_Splice_Site_p.S131_splice			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	186					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTACTTACAGCTGCCAAATT	0.393000													7	93					0	0	1	0	0
NCR3	259197	broad.mit.edu	37	6	31557903	31557903	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31557903C>T	ENST00000376073.4	-	2	307	c.43_splice	c.e2-1	p.G15_splice	NCR3_ENST00000491161.1_5'UTR|NCR3_ENST00000376072.3_Splice_Site_p.G15_splice|NCR3_ENST00000376071.4_Splice_Site_p.G15_splice|NCR3_ENST00000340027.5_Splice_Site_p.G15_splice	NM_001145466.1	NP_001138938.1	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	15					cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			cervix(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)	9						AGCACAGGATCCTGGGGGCAG	0.552000													20	38					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7670265	7670265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7670265C>T	ENST00000446248.2	+	2	403	c.302C>T	c.(301-303)cCc>cTc	p.P101L	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.P101L	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	101					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CCCCCCAACCCCTCTGCACTG	0.682000													25	129					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647268	121647268	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121647268G>A	ENST00000489711.1	+	15	1595	c.1206_splice	c.e15-1	p.E403_splice	SLC15A2_ENST00000295605.2_Splice_Site_p.E372_splice|SLC15A2_ENST00000465060.1_3'UTR	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	403					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TTGCTCTAAGGAAATGGCCCC	0.463000													49	163					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502456	91502456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91502456G>A	ENST00000266718.4	-	2	755	c.301C>T	c.(301-303)Ctt>Ttt	p.L101F	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	101				L -> V (in Ref. 1; AAA85268).	collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TTTTCTAGAAGGTTGTGATCT	0.388000													23	54					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54905628	54905628	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54905628G>A	ENST00000293373.6	+	8	856	c.777G>A	c.(775-777)tgG>tgA	p.W259*	NCKAP1L_ENST00000552211.1_3'UTR|NCKAP1L_ENST00000545638.2_Nonsense_Mutation_p.W209*	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	259					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TGGAGCGCTGGATTATCAGTA	0.413000													51	98					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604199	179604199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179604199C>T	ENST00000589042.1	-	48	13985	c.13761G>A	c.(13759-13761)gaG>gaA	p.E4587E	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Silent_p.E4270E|TTN_ENST00000342175.6_Silent_p.E4416E|TTN_ENST00000359218.5_Silent_p.E4349E|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.E4224E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4270	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTAGCAACCTCCTCAGTAC	0.458000													18	72					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99723945	99723945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:99723945C>T	ENST00000345514.2	-	2	556	c.290G>A	c.(289-291)aGc>aAc	p.S97N	BCL11B_ENST00000357195.3_Missense_Mutation_p.S97N|BCL11B_ENST00000443726.2_Intron	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	496						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GGGTGGCGGGCTGTCCTTGTC	0.597000			T	TLX3	T-ALL								7	92					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113287617	113287617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113287617G>A	ENST00000362072.3	-	4	844	c.500C>T	c.(499-501)tCc>tTc	p.S167F	DRD2_ENST00000535984.1_Intron|DRD2_ENST00000346454.3_Missense_Mutation_p.S167F|DRD2_ENST00000542968.1_Missense_Mutation_p.S167F|DRD2_ENST00000538967.1_Missense_Mutation_p.S167F|DRD2_ENST00000355319.2_Missense_Mutation_p.S167F|DRD2_ENST00000544518.1_Missense_Mutation_p.S166F	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	167					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GAGTGGGCAGGAGATGGTGAA	0.592000													8	33					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11862215	11862215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11862215G>A	ENST00000396516.2	-	11	1513	c.1316C>T	c.(1315-1317)aCc>aTc	p.T439I	ZC3H7A_ENST00000355758.4_Missense_Mutation_p.T439I			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	439						nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						CAATTCATGGGTTCCTTCGAG	0.408000													55	126					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607827	84607827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84607827G>A	ENST00000344803.2	+	4	2489	c.2442G>A	c.(2440-2442)ggG>ggA	p.G814G		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		ATCTGTCAGGGAATGACTCAG	0.453000													24	42					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61570930	61570930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61570930G>A	ENST00000577647.1	+	9	1369	c.1324G>A	c.(1324-1326)Gag>Aag	p.E442K	ACE_ENST00000290863.6_Missense_Mutation_p.E442K|ACE_ENST00000413513.3_Missense_Mutation_p.E442K|ACE_ENST00000290866.4_Missense_Mutation_p.E1016K|ACE_ENST00000490216.2_Missense_Mutation_p.E442K|ACE_ENST00000428043.1_Missense_Mutation_p.E1016K|ACE_ENST00000421982.2_Missense_Mutation_p.E262K			P12821	ACE_HUMAN	angiotensin I converting enzyme	1016	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CGGCTTCCATGAGGCCATTGG	0.592000													10	74					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95606880	95606880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:95606880G>A	ENST00000324972.6	+	7	791	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	DYNC1I1_ENST00000457059.1_Missense_Mutation_p.E183K|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.E163K|DYNC1I1_ENST00000447467.2_Missense_Mutation_p.E183K|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.E180K|DYNC1I1_ENST00000359388.4_Missense_Mutation_p.E163K	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	200					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CTCAGAACTGGAAAATCAGGA	0.323000													5	41					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65016088	65016088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:65016088G>A	ENST00000394156.3	-	8	1569	c.1116C>T	c.(1114-1116)atC>atT	p.I372I	CDH11_ENST00000268603.4_Silent_p.I372I|CDH11_ENST00000566827.1_Silent_p.I246I			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	372	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CTTCTACTGAGATCTTGACGG	0.517000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			25	94					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97810277	97810277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97810277C>T	ENST00000420699.2	+	9	1168	c.924C>T	c.(922-924)gcC>gcT	p.A308A	ANKRD36_ENST00000461153.2_Silent_p.A308A	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	308										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						AACAACCGGCCTTGAAGGTAT	0.318000													9	29					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1823746	1823746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1823746G>A	ENST00000170168.4	-	4	2149	c.2055C>T	c.(2053-2055)gcC>gcT	p.A685A	CTB-31O20.4_ENST00000593201.1_RNA|CTB-31O20.4_ENST00000587741.1_RNA	NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	685						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGGGGCCGGGCCGGGGGCA	0.741000													4	3					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45837921	45837921	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45837921C>T	ENST00000397928.1	+	21	3703	c.3258C>T	c.(3256-3258)ctC>ctT	p.L1086L	TRPM2_ENST00000300481.9_Silent_p.L1066L|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Silent_p.L1086L|TRPM2_ENST00000397932.2_Silent_p.L1086L	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1086						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ccTTCATCCTCCTCAGCCACC	0.627000													43	68					0	0	1	0	0
SLC9A7	84679	broad.mit.edu	37	X	46522065	46522065	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:46522065C>T	ENST00000328306.4	-	6	832	c.807G>A	c.(805-807)gcG>gcA	p.A269A		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	269					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						CATTAAATATCGCCAGCACAG	0.403000													20	16					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111166	55111166	+	Silent	SNP	C	C	T	rs144421988	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55111166C>T	ENST00000314721.2	+	1	540	c.490C>T	c.(490-492)Cta>Tta	p.L164L		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						TCTGTACAGTCTACCAATCTG	0.443000													31	145					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24822131	24822131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24822131G>A	ENST00000376451.2	+	11	2688	c.2428G>A	c.(2428-2430)Gaa>Aaa	p.E810K	KIAA1217_ENST00000307544.6_Missense_Mutation_p.E810K|KIAA1217_ENST00000376452.3_Missense_Mutation_p.E1091K|KIAA1217_ENST00000458595.1_Missense_Mutation_p.E1092K|KIAA1217_ENST00000376462.1_Missense_Mutation_p.E1047K|KIAA1217_ENST00000376454.3_Missense_Mutation_p.E1127K|KIAA1217_ENST00000396445.1_Missense_Mutation_p.E810K|KIAA1217_ENST00000396446.1_Missense_Mutation_p.E810K			Q5T5P2	SKT_HUMAN	KIAA1217	1127					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGAGGAAGAAGAAGAAGAAGG	0.552000													15	60					0	0	1	0	0
DECR2	26063	broad.mit.edu	37	16	461033	461033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:461033C>T	ENST00000219481.5	+	7	756	c.618C>T	c.(616-618)ctC>ctT	p.L206L	DECR2_ENST00000424398.2_Silent_p.L194L|DECR2_ENST00000461947.1_3'UTR	NM_020664.3	NP_065715.1	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2, peroxisomal	206						peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)	9		Hepatocellular(16;0.00015)				TCAACAGCCTCGCCCCTGGCC	0.642000													4	11					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84363153	84363153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84363153C>T	ENST00000509231.1	-	1	901	c.822G>A	c.(820-822)atG>atA	p.M274I	SATL1_ENST00000395409.3_Missense_Mutation_p.M87I|SATL1_ENST00000332921.5_Missense_Mutation_p.M87I			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	87	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						GGTTCATGTCCATTTGGTTCA	0.448000													19	52					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98155083	98155083	+	Silent	SNP	C	C	T	rs151335014		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98155083C>T	ENST00000357947.3	-	13	1812	c.1587G>A	c.(1585-1587)acG>acA	p.T529T	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	529	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.T529T(1)		NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CACTCTCTTCCGTGGGGCCAT	0.527000													29	72					0	0	1	0	0
IGHV4-34	28395	broad.mit.edu	37	14	106829885	106829885	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106829885G>A	ENST00000390616.2	-	0	108																											GCTGCACCTGGGACAGGACCC	0.562000													20	44					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38847158	38847158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38847158G>A	ENST00000409235.3	+	10	1285	c.1170G>A	c.(1168-1170)caG>caA	p.Q390Q	CATSPERG_ENST00000215069.4_Intron|CATSPERG_ENST00000410018.1_Silent_p.Q390Q	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	390					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						TGCCCAGGCAGTGGTCTGTGT	0.607000													23	78					0	0	1	0	0
F11R	50848	broad.mit.edu	37	1	160969689	160969689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160969689G>A	ENST00000368026.6	-	6	945	c.671C>T	c.(670-672)tCa>tTa	p.S224L	F11R_ENST00000289779.3_3'UTR|F11R_ENST00000537746.1_Missense_Mutation_p.S175L	NM_016946.4	NP_058642.1	Q9Y624	JAM1_HUMAN	F11 receptor	224	Ig-like V-type 2.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)	12	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			CACAGCATTTGAAGTCATGGG	0.517000													21	73					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168103648	168103648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168103648G>A	ENST00000409195.1	+	9	5835	c.5746G>A	c.(5746-5748)Gag>Aag	p.E1916K	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1916K|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1694K|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1741					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TCTGAAAAAGGAGCTTCTCAA	0.353000													16	51					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757480	8757480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8757480C>T	ENST00000229335.6	-	4	569	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	AICDA_ENST00000537228.1_Missense_Mutation_p.E146K	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	156					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					AAAGTTCTTTCGTGGTTTTCT	0.423000													45	92					0	0	1	0	0
EIF3B	8662	broad.mit.edu	37	7	2402289	2402289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2402289C>T	ENST00000360876.4	+	3	758	c.702C>T	c.(700-702)ttC>ttT	p.F234F	EIF3B_ENST00000397011.2_Silent_p.F234F	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	234	RRM.|Sufficient for interaction with EIF3E.|Sufficient for interaction with EIF3J.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GGTATATTTTCCTGGAGTACG	0.587000													22	48					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38950158	38950158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38950158C>T	ENST00000359357.3	+	84	12474	c.12220C>T	c.(12220-12222)Ccc>Tcc	p.P4074S	DNAH8_ENST00000441566.1_Missense_Mutation_p.P4038S					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATGGAATATTCCCTACGAATT	0.353000													15	207					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627648	21627648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:21627648G>A	ENST00000425654.2	+	19	2995	c.2515G>A	c.(2515-2517)Gat>Aat	p.D839N	CNKSR2_ENST00000379510.3_Missense_Mutation_p.D869N|CNKSR2_ENST00000279451.4_Missense_Mutation_p.D869N|CNKSR2_ENST00000543067.1_Missense_Mutation_p.D820N	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	869					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TGACCCACAGGATGACGTGCA	0.522000													34	21					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74043403	74043403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74043403G>A	ENST00000409561.1	+	3	2174	c.2053G>A	c.(2053-2055)Gag>Aag	p.E685K		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	685										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TAAAGGCCCGGAGAAAATTCA	0.512000													7	70					0	0	1	0	0
KRR1	11103	broad.mit.edu	37	12	75897712	75897712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:75897712G>A	ENST00000229214.4	-	7	826	c.803C>T	c.(802-804)cCa>cTa	p.P268L	KRR1_ENST00000438169.2_Intron	NM_007043.6	NP_008974.5	Q13601	KRR1_HUMAN	KRR1, small subunit (SSU) processome component, homolog (yeast)	268	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	11						TGGTGGGAATGGCGTATATTC	0.343000													24	204					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31317934	31317934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31317934G>A	ENST00000265071.2	+	11	2050	c.1785G>A	c.(1783-1785)ggG>ggA	p.G595G	CDH6_ENST00000514738.1_Silent_p.G540G	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	595	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ACCACCACGGGAACATGCAAT	0.572000													23	42					0	0	1	0	0
TUBA1B	10376	broad.mit.edu	37	12	49523142	49523142	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49523142G>A	ENST00000336023.5	-	3	352	c.258C>T	c.(256-258)ctC>ctT	p.L86L	RP11-386G11.10_ENST00000547387.1_RNA	NM_006082.2	NP_006073.2	P68363	TBA1B_HUMAN	tubulin, alpha 1b	86					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(4)	12						CAGGGTGGAAGAGCTGGCGGT	0.557000													51	106					0	0	1	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43694429	43694429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:43694429C>T	ENST00000395809.1	-	9	3490	c.984G>A	c.(982-984)ctG>ctA	p.L328L	RASGEF1A_ENST00000374459.1_Silent_p.L336L|RASGEF1A_ENST00000395810.1_Silent_p.L328L			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	328	Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						AAGTTTTCTTCAGCCTTGCCA	0.622000													49	87					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95480899	95480899	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95480899G>A	ENST00000356884.6	-	5	2095	c.2028C>T	c.(2026-2028)atC>atT	p.I676I	BICD2_ENST00000375512.3_Silent_p.I676I	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	676	Interacts with RAB6A (By similarity).				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						TCAGCTTGAGGATCTCCTCCA	0.642000													22	183					0	0	1	0	0
GNAT3	346562	broad.mit.edu	37	7	80108268	80108268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:80108268C>T	ENST00000398291.3	-	4	443	c.350G>A	c.(349-351)gGt>gAt	p.G117D	CD36_ENST00000435819.1_Intron	NM_001102386.1	NP_001095856.1	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha transducing 3	117					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	9						TGTCATGCCACCATCTTCCAG	0.418000													33	103					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113943683	113943683	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113943683G>A	ENST00000245796.6	+	5	1674	c.1479G>A	c.(1477-1479)ttG>ttA	p.L493L	PSD4_ENST00000441564.2_Silent_p.L465L	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	493					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTTCACTCTTGGAGACGGATG	0.567000													26	68					0	0	1	0	0
SENP8	123228	broad.mit.edu	37	15	72432043	72432043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72432043C>T	ENST00000544411.1	+	3	566	c.79C>T	c.(79-81)Ctc>Ttc	p.L27F	SENP8_ENST00000542035.2_Missense_Mutation_p.L27F|SENP8_ENST00000340912.4_Missense_Mutation_p.L27F|SENP8_ENST00000544171.1_Missense_Mutation_p.L27F	NM_001172109.1|NM_001172110.1	NP_001165580.1|NP_001165581.1	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	27	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			breast(1)|kidney(2)|lung(1)|ovary(1)|skin(1)	6						GCCAAGCTGGCTCAATGACCA	0.488000													66	205					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124756633	124756633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124756633C>T	ENST00000306534.3	-	16	3006	c.2521G>A	c.(2521-2523)Gac>Aac	p.D841N	ROBO4_ENST00000533054.1_Missense_Mutation_p.D696N|RP11-664I21.5_ENST00000524453.1_RNA	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	841					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CTGCCCATGTCCGTGAACTCT	0.652000													13	41					0	0	1	0	0
ZNF702P	79986	broad.mit.edu	37	19	53473988	53473988	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53473988C>T	ENST00000600068.1	-	0	377				ZNF702P_ENST00000270443.4_RNA																							AAGGAAAAATCTCCAGTGTGA	0.408000													13	132					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124117644	124117644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124117644G>A	ENST00000360013.3	+	13	2393	c.2266G>A	c.(2266-2268)Gag>Aag	p.E756K	KALRN_ENST00000240874.3_Missense_Mutation_p.E756K|KALRN_ENST00000460856.1_Missense_Mutation_p.E756K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	756					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCAGATGGAGGAGCTGTTCCA	0.582000													33	86					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585896	179585896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179585896G>A	ENST00000589042.1	-	79	23074	c.22850C>T	c.(22849-22851)tCa>tTa	p.S7617L	TTN_ENST00000342992.6_Missense_Mutation_p.S6373L|TTN_ENST00000591111.1_Missense_Mutation_p.S7300L|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7300	Ig-like 58.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAACTTTTGAAGCTTCTAA	0.348000													15	35					0	0	1	0	0
TRIM40	135644	broad.mit.edu	37	6	30105149	30105149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30105149C>T	ENST00000396581.1	+	2	722	c.336C>T	c.(334-336)agC>agT	p.S112S	TRIM40_ENST00000307859.4_Silent_p.S112S|TRIM40_ENST00000376724.2_Silent_p.S112S			Q6P9F5	TRI40_HUMAN	tripartite motif containing 40	112						intracellular	zinc ion binding			ovary(1)	1						ATGCCCTCAGCCACTACAAGG	0.547000													11	82					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2542544	2542544	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2542544C>T	ENST00000358864.1	+	4	457	c.442C>T	c.(442-444)Ctg>Ttg	p.L148L		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	148	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGGGGAGTCCCTGTCCGAGGA	0.607000													24	65					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51379750	51379750	+	Missense_Mutation	SNP	C	C	T	rs147080743		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51379750C>T	ENST00000325321.3	+	3	454	c.229C>T	c.(229-231)Cgg>Tgg	p.R77W	KLK2_ENST00000391810.2_5'UTR|KLK2_ENST00000597509.1_3'UTR|KLK2_ENST00000358049.4_Missense_Mutation_p.R77W			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	77	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		CTGGCTGGGTCGGCACAACCT	0.567000			T	ETV4	prostate								16	41					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553997	140553997	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140553997C>T	ENST00000231137.3	+	1	1755	c.1581C>T	c.(1579-1581)ttC>ttT	p.F527F		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		527	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAGGCGTTCGAGTTCCGCG	0.701000													54	106					0	0	1	0	0
WLS	79971	broad.mit.edu	37	1	68619310	68619310	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:68619310G>A	ENST00000262348.4	-	5	946	c.693C>T	c.(691-693)acC>acT	p.T231T	GNG12-AS1_ENST00000420587.1_RNA|WLS_ENST00000540432.1_Silent_p.T231T|GNG12-AS1_ENST00000413628.1_RNA|WLS_ENST00000491811.1_5'UTR|WLS_ENST00000354777.2_Silent_p.T229T|WLS_ENST00000370976.3_Silent_p.T140T	NM_024911.6	NP_079187.3	Q5T9L3	WLS_HUMAN	wntless Wnt ligand secretion mediator	231	Interacts with Wnt proteins (By similarity).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)|prostate(3)|urinary_tract(1)	20						ACCACACCTTGGTGAAGCCTC	0.463000													19	49					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16892697	16892697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:16892697G>A	ENST00000355661.3	-	4	264	c.254C>T	c.(253-255)cCt>cTt	p.P85L	PLEKHA7_ENST00000448080.2_Missense_Mutation_p.P85L|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.P85L|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	85	WW 2.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TCCCGTCACAGGATGCCTGAA	0.428000													16	69					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160277257	160277257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:160277257C>T	ENST00000264431.4	+	23	4840	c.4421C>T	c.(4420-4422)tCt>tTt	p.S1474F		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1474					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CCGAACGAGTCTGACCCGCGC	0.537000													15	33					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203194880	203194880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203194880G>A	ENST00000367229.1	-	3	208	c.174C>T	c.(172-174)ttC>ttT	p.F58F	CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000535569.1_Silent_p.F68F|CHIT1_ENST00000255427.3_Silent_p.F58F	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	58					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						TCATGCCAGCGAAGGCGTAGA	0.572000													7	84					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6381394	6381394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6381394G>A	ENST00000394456.5	-	9	1458	c.994C>T	c.(994-996)Ccg>Tcg	p.P332S	GTF2F1_ENST00000429701.2_Missense_Mutation_p.P247S	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	332	Glu-rich.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						TTCTCCTGCGGGGTGGGTGcc	0.652000													5	22					0	0	1	0	0
ZNF662	389114	broad.mit.edu	37	3	42956100	42956100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42956100C>T	ENST00000541208.1	+	5	904	c.535C>T	c.(535-537)Ctt>Ttt	p.L179F	ZNF662_ENST00000440367.2_Missense_Mutation_p.L179F|ZNF662_ENST00000422021.1_Intron|ZNF662_ENST00000328199.6_Missense_Mutation_p.L205F|KRBOX1_ENST00000426937.1_Intron			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		CAATAACCTCCTTGGTATACA	0.348000													31	71					0	0	1	0	0
EFHD1	80303	broad.mit.edu	37	2	233546349	233546349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233546349G>A	ENST00000264059.3	+	4	1117	c.640G>A	c.(640-642)Gat>Aat	p.D214N	EFHD1_ENST00000409613.1_Missense_Mutation_p.D118N|EFHD1_ENST00000410095.1_Missense_Mutation_p.D102N|EFHD1_ENST00000409708.1_Missense_Mutation_p.D102N	NM_025202.3	NP_079478.1	Q9BUP0	EFHD1_HUMAN	EF-hand domain family, member D1	214							calcium ion binding|protein binding			NS(1)|breast(1)|large_intestine(2)|lung(3)	7		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Breast(86;0.0199)|Renal(207;0.025)		Epithelial(121;2.08e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00825)|Lung(119;0.0101)		AGCTGAGCAAGATGAGCGGAA	0.542000													58	101					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67333348	67333348	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67333348G>A	ENST00000304372.5	-	6	959	c.904C>T	c.(904-906)Ctg>Ttg	p.L302L	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	302						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		AGCTGGCCCAGCGCAGAGTCC	0.627000													31	78					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9523353	9523353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9523353G>A	ENST00000378429.3	-	10	2430	c.1884C>T	c.(1882-1884)tcC>tcT	p.S628S	PAK7_ENST00000378423.1_Silent_p.S628S|PAK7_ENST00000353224.5_Silent_p.S628S	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	628	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TGATCCCGAGGGACCAGATGT	0.517000													19	76					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24442461	24442461	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:24442461G>A	ENST00000383168.4	-	2	260	c.132C>T	c.(130-132)gcC>gcT	p.A44A	AQP4_ENST00000581374.1_Silent_p.A22A|AQP4-AS1_ENST00000579964.1_RNA|AQP4-AS1_ENST00000582605.1_RNA|AQP4_ENST00000440832.3_Silent_p.A22A	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	44					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					AAATAAGCATGGCCAGAAATT	0.488000													83	186					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360640	27360640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27360640G>A	ENST00000335524.3	-	3	1083	c.558C>T	c.(556-558)tcC>tcT	p.S186S		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	186										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGGGACCCGGACCCAGTGT	0.637000													21	60					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233393906	233393906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233393906C>T	ENST00000258229.8	-	5	1936	c.1702G>A	c.(1702-1704)Gga>Aga	p.G568R	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	568						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GGCATTTGTCCTTCCTTAGCC	0.423000													14	54					0	0	1	0	0
MOGAT1	116255	broad.mit.edu	37	2	223559950	223559950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:223559950G>A	ENST00000446656.3	+	5	796	c.796G>A	c.(796-798)Gga>Aga	p.G266R		NM_058165.2	NP_477513.2	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	266					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)|cervix(1)|endometrium(1)|lung(5)|urinary_tract(1)	9		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		TCATGCCAGGGGAGTTTTTCA	0.388000													5	27					0	0	1	0	0
HOXC4	3221	broad.mit.edu	37	12	54448070	54448070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54448070C>T	ENST00000430889.2	+	1	410	c.364C>T	c.(364-366)Ccc>Tcc	p.P122S	HOXC4_ENST00000303406.4_Missense_Mutation_p.P122S	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	122						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						CCAGCCAGCCCCCGACCATCC	0.637000													10	25					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44418275	44418275	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44418275T>A	ENST00000269973.5	-	10	2403	c.1313A>T	c.(1312-1314)cAt>cTt	p.H438L	ZNF45_ENST00000589703.1_Missense_Mutation_p.H438L|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	438					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						TTCCCCTGTATGGACTCTAAA	0.478000													32	110					0	0	1	0	0
KLF11	8462	broad.mit.edu	37	2	10187786	10187786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:10187786C>T	ENST00000535335.1	+	3	487	c.271C>T	c.(271-273)Cct>Tct	p.P91S	KLF11_ENST00000305883.1_Missense_Mutation_p.P108S|KLF11_ENST00000540845.1_Missense_Mutation_p.P91S	NM_001177718.1	NP_001171189.1	O14901	KLF11_HUMAN	Kruppel-like factor 11	108					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GTGCATAACTCCTCCTCAGAG	0.413000													12	75					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28497335	28497335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28497335C>T	ENST00000412168.2	+	2	284	c.195C>T	c.(193-195)ctC>ctT	p.L65L	GPX5_ENST00000442674.2_3'UTR|GPX5_ENST00000469384.1_Silent_p.L65L	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	65					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	AGCACATCCTCTTCGTCAACG	0.438000													37	68					0	0	1	0	0
OFCC1	266553	broad.mit.edu	37	6	9900697	9900697	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:9900697C>T	ENST00000316020.6	-	6	572	c.573G>A	c.(571-573)ctG>ctA	p.L191L	OFCC1_ENST00000472329.1_5'UTR					orofacial cleft 1 candidate 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)	11	Ovarian(93;0.0473)|Breast(50;0.201)	all_hematologic(90;0.124)				CTTCAGAATTCAGAGTCTCCT	0.443000													46	112					0	0	1	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134497253	134497253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:134497253G>A	ENST00000372195.1	-	11	2078	c.1835C>T	c.(1834-1836)tCc>tTc	p.S612F	RAPGEF1_ENST00000372189.3_Missense_Mutation_p.S595F|RAPGEF1_ENST00000372190.3_Missense_Mutation_p.S613F			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	595					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CCCACTGAAGGAGTCGCTGAA	0.612000													6	15					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40648100	40648100	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:40648100G>A	ENST00000342449.3	-	12	1222	c.1145_splice	c.e12+1	p.R382_splice	BRWD1_ENST00000333229.2_Splice_Site_p.R382_splice|BRWD1_ENST00000380800.3_Splice_Site_p.R382_splice	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CACACTTACCGATCACCATTG	0.328000													39	97					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179745905	179745905	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179745905G>A	ENST00000253778.8	-	10	1015	c.846C>T	c.(844-846)atC>atT	p.I282I	GFPT2_ENST00000520165.1_5'UTR	NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	282	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CCACTGCGGCGATGTCATCGT	0.582000													19	32					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57731603	57731603	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57731603A>T	ENST00000281282.5	+	2	1484	c.1406A>T	c.(1405-1407)aAa>aTa	p.K469I		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	469	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		ATAGATGGGAAAGTTCTGGAA	0.582000													22	66					0	0	1	0	0
RAD51AP1	10635	broad.mit.edu	37	12	4662198	4662198	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4662198C>T	ENST00000228843.9	+	8	707	c.657C>T	c.(655-657)gaC>gaT	p.D219D	RAD51AP1_ENST00000544927.1_Silent_p.D202D|RAD51AP1_ENST00000544931.1_3'UTR|RAD51AP1_ENST00000352618.4_Silent_p.D202D|RAD51AP1_ENST00000543041.1_Silent_p.D84D|RAD51AP1_ENST00000321524.7_Silent_p.D219D	NM_001130862.1	NP_001124334.1	Q96B01	R51A1_HUMAN	RAD51 associated protein 1	219					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|RNA binding|single-stranded DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			AGGATAATGACGAAGACTTCT	0.313000													10	37					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139189308	139189308	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139189308G>A	ENST00000274710.3	+	2	488	c.283G>A	c.(283-285)Gag>Aag	p.E95K		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	95					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATTCAGCGGAGTCCAGGCC	0.612000													34	109					0	0	1	0	0
BIRC5	332	broad.mit.edu	37	17	76219712	76219712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76219712C>T	ENST00000374948.2	+	3	441	c.388C>T	c.(388-390)Cct>Tct	p.P130S	BIRC5_ENST00000350051.3_3'UTR|BIRC5_ENST00000301633.4_3'UTR|BIRC5_ENST00000589892.1_3'UTR|AC087645.1_ENST00000600484.1_Missense_Mutation_p.E190K	NM_001012270.1	NP_001012270.1	O15392	BIRC5_HUMAN	baculoviral IAP repeat containing 5	0					anti-apoptosis|apoptosis|cell division|chromosome segregation|cytokinesis|establishment of chromosome localization|G2/M transition of mitotic cell cycle|mitosis|mitotic prometaphase|positive regulation of exit from mitosis|positive regulation of mitotic cell cycle|protein complex localization|spindle checkpoint	centriole|chromosome passenger complex|chromosome, centromeric region|cytoplasm|cytoplasmic microtubule|cytosol|interphase microtubule organizing center|midbody|nuclear chromosome|spindle|spindle microtubule	caspase inhibitor activity|chaperone binding|cobalt ion binding|cofactor binding|cysteine-type endopeptidase inhibitor activity|metal ion binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|Ran GTPase binding|zinc ion binding			kidney(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.153)			CACCAGCCTTCCTGTGGGCCC	0.527000													11	23					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69329379	69329379	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:69329379G>A	ENST00000260364.5	+	9	1447	c.1146G>A	c.(1144-1146)tgG>tgA	p.W382*	NOX5_ENST00000448182.3_Nonsense_Mutation_p.W354*|NOX5_ENST00000530406.2_Nonsense_Mutation_p.W372*|NOX5_ENST00000455873.3_Nonsense_Mutation_p.W365*|NOX5_ENST00000388866.3_Nonsense_Mutation_p.W400*			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	400	Ferric oxidoreductase.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						TGTTCTATTGGACTCACCTGT	0.557000													112	151					0	0	1	0	0
COG6	57511	broad.mit.edu	37	13	40239278	40239278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:40239278C>T	ENST00000416691.1	+	4	515	c.415C>T	c.(415-417)Ctt>Ttt	p.L139F	COG6_ENST00000455146.3_Missense_Mutation_p.L139F	NM_001145079.1	NP_001138551.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6	139					protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		AACCACTAAGCTTCAATCTGA	0.259000													27	71					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881631	26881631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:26881631C>T	ENST00000231021.4	-	12	2156	c.1984G>A	c.(1984-1986)Gaa>Aaa	p.E662K		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	662					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CCGCCGCCTTCATCGTTGTAG	0.438000													72	129					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15729966	15729966	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15729966T>A	ENST00000378076.3	-	3	768	c.415A>T	c.(415-417)Aca>Tca	p.T139S		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	139					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						GCTTTCACTGTTGCTCCAAAC	0.423000													20	126					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78695312	78695312	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:78695312G>A	ENST00000436010.2	-	19	3748	c.2751C>T	c.(2749-2751)gtC>gtT	p.V917V	ROBO1_ENST00000495273.1_Silent_p.V911V|ROBO1_ENST00000467549.1_Silent_p.V911V|ROBO1_ENST00000464233.1_Silent_p.V956V			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	956					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CTCCACTGCTGACAGCTTCGC	0.348000													27	83					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419851	130419851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:130419851G>A	ENST00000370904.1	-	10	1152	c.242C>T	c.(241-243)tCa>tTa	p.S81L	IGSF1_ENST00000370910.1_Missense_Mutation_p.S81L|IGSF1_ENST00000370903.3_Missense_Mutation_p.S90L|IGSF1_ENST00000361420.3_Missense_Mutation_p.S90L|IGSF1_ENST00000370900.1_Missense_Mutation_p.S90L|IGSF1_ENST00000370901.4_Missense_Mutation_p.S90L			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	90	Ig-like C2-type 1.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TATAAGGAATGAAACTTGGAA	0.512000													55	52					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41100936	41100936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:41100936C>T	ENST00000373198.3	-	8	1655	c.1420G>A	c.(1420-1422)Gag>Aag	p.E474K	PTPRT_ENST00000373187.1_Missense_Mutation_p.E474K|PTPRT_ENST00000373193.3_Missense_Mutation_p.E474K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E474K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E474K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E474K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E474K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	474	Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACCAGCTCCTCGCTCTCCATT	0.587000													14	96					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113999206	113999206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113999206G>A	ENST00000429538.3	-	7	893	c.699C>T	c.(697-699)ctC>ctT	p.L233L	AC016683.6_ENST00000451179.1_RNA|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000333145.5_RNA|PAX8_ENST00000348715.5_Silent_p.L233L|PAX8_ENST00000263335.7_Silent_p.L233L|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000397647.3_Silent_p.L233L|PAX8_ENST00000263334.5_Silent_p.L233L|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000422956.1_RNA	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	233					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						CGAGCGGCTCGAGGTGGTGCT	0.627000			T	PPARG	follicular thyroid		Thyroid dysgenesis						24	24					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192595	152192595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152192595C>T	ENST00000368801.2	-	3	1585	c.1510G>A	c.(1510-1512)Ggt>Agt	p.G504S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	504					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCGTTCACCCCTAGATGAC	0.552000													109	339					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23065577	23065577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23065577G>A	ENST00000246006.4	-	1	1400	c.1253C>T	c.(1252-1254)gCc>gTc	p.A418V		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	418	EGF-like 4; calcium-binding (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTCCTCCCCGGCCAGGACGTA	0.637000													33	62					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139890497	139890497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139890497C>T	ENST00000303045.6	-	3	600	c.154G>A	c.(154-156)Gag>Aag	p.E52K	COL22A1_ENST00000435777.1_Missense_Mutation_p.E52K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	52	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCAAAGTCCTCCTTGCCCACG	0.637000										HNSCC(7;0.00092)			5	12					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55655610	55655610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55655610G>A	ENST00000449290.2	+	4	702	c.610G>A	c.(610-612)Gag>Aag	p.E204K	TRIM51_ENST00000244891.3_Missense_Mutation_p.E61K	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	204						intracellular	zinc ion binding	p.E204K(1)|p.E45K(1)									GCTGCGAAAGGAGGGCGAGGA	0.423000													33	70					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061161	9061161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9061161G>A	ENST00000397910.4	-	3	26488	c.26285C>T	c.(26284-26286)tCa>tTa	p.S8762L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8764	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATTTCTGGTGATATTGTGGA	0.502000													20	80					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832883	61832883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61832883C>T	ENST00000280772.1	-	37	7947	c.7756G>A	c.(7756-7758)Gaa>Aaa	p.E2586K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2586					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTCAGTTTTTCTTCAGCCTCC	0.433000													44	93					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3000022	3000022	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3000022G>A	ENST00000520002.1	-	42	6764	c.6209C>T	c.(6208-6210)tCg>tTg	p.S2070L	CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000542608.1_Missense_Mutation_p.S2069L|CSMD1_ENST00000400186.3_Missense_Mutation_p.S2070L|CSMD1_ENST00000602557.1_Missense_Mutation_p.S2070L|CSMD1_ENST00000537824.1_Missense_Mutation_p.S2069L|CSMD1_ENST00000602723.1_Missense_Mutation_p.S2070L|CSMD1_ENST00000539096.1_Missense_Mutation_p.S2069L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2070	CUB 12.					integral to membrane		p.S2069L(1)|p.S1798L(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCGGTTTTGCGAATGGTCACT	0.453000													11	43					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50216681	50216681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50216681C>T	ENST00000392518.4	+	20	2603	c.2231C>T	c.(2230-2232)tCc>tTc	p.S744F	CPT1C_ENST00000405931.2_Missense_Mutation_p.S733F|CPT1C_ENST00000323446.5_Missense_Mutation_p.S744F|CPT1C_ENST00000354199.5_Missense_Mutation_p.S655F|CPT1C_ENST00000598293.1_Missense_Mutation_p.S744F	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	744					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTCCAGGATTCCCACAGGCTG	0.592000													22	72					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97851545	97851545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97851545G>A	ENST00000354565.2	+	1	4	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						TGAGGACATGGAAGAGGAAAA	0.398000													62	147					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10114359	10114359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10114359G>A	ENST00000264828.3	-	6	816	c.731C>T	c.(730-732)cCt>cTt	p.P244L		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	244	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CTTCCGCCGAGGACGAGGGGT	0.577000													9	79					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10465377	10465377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10465377C>T	ENST00000382483.3	-	4	6454	c.6231G>A	c.(6229-6231)gaG>gaA	p.E2077E		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2077					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTGGGTGGGCCTCCCCTTCTG	0.642000													26	244					0	0	1	0	0
TSPAN8	7103	broad.mit.edu	37	12	71531781	71531781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71531781C>T	ENST00000393330.2	-	9	948	c.396G>A	c.(394-396)ggG>ggA	p.G132G	TSPAN8_ENST00000546561.1_Silent_p.G132G|TSPAN8_ENST00000552128.1_Silent_p.G49G|TSPAN8_ENST00000247829.3_Silent_p.G132G			P19075	TSN8_HUMAN	tetraspanin 8	132					protein glycosylation	integral to membrane|lysosome	signal transducer activity			breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(7)|skin(3)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			TTTCACTTTCCCCTGTGGCGC	0.353000													33	114					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432226	140432226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140432226C>T	ENST00000306549.3	+	1	1248	c.1171C>T	c.(1171-1173)Ccc>Tcc	p.P391S		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		391	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAAGACCTTCCCTTTGTAAT	0.473000													41	77					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65263284	65263284	+	Silent	SNP	G	G	A	rs150377252		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65263284G>A	ENST00000389722.3	-	10	1385	c.1332C>T	c.(1330-1332)ctC>ctT	p.L444L	SPTB_ENST00000556626.1_Silent_p.L444L|SPTB_ENST00000542895.1_Silent_p.L444L|SPTB_ENST00000389721.5_Silent_p.L444L|SPTB_ENST00000389720.3_Silent_p.L444L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	444					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTGGGCCACGAGGCGCTGGT	0.587000													14	76					0	0	1	0	0
DCAF6	55827	broad.mit.edu	37	1	168014196	168014196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168014196C>T	ENST00000367840.3	+	16	2083	c.1989C>T	c.(1987-1989)gaC>gaT	p.D663D	DCAF6_ENST00000432587.2_Silent_p.D632D|DCAF6_ENST00000367843.3_Silent_p.D606D|DCAF6_ENST00000312263.6_Silent_p.D586D	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	603					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						AAAGAAATGACCTCAATCTTG	0.428000													53	172					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56342232	56342232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56342232C>T	ENST00000262290.4	+	10	1732	c.1416C>T	c.(1414-1416)ccC>ccT	p.P472P	LPO_ENST00000421678.2_Silent_p.P389P|LPO_ENST00000543544.1_Silent_p.P413P|LPO_ENST00000582328.1_Silent_p.P389P	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	472					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						TGGAGGTCCCCTCTAGTATGT	0.517000													28	59					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47841699	47841699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47841699C>T	ENST00000371764.4	+	6	665	c.656C>T	c.(655-657)tCg>tTg	p.S219L	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	219						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAAAACCTCTCGTTCCAGGAC	0.418000													36	118					0	0	1	0	0
RNF122	79845	broad.mit.edu	37	8	33416195	33416195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:33416195G>A	ENST00000256257.1	-	2	521	c.120C>T	c.(118-120)gtC>gtT	p.V40V		NM_024787.2	NP_079063.2	Q9H9V4	RN122_HUMAN	ring finger protein 122	40						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding			endometrium(2)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		TGCCGAAGATGACCATATAGA	0.537000													19	78					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370810	35370810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35370810G>A	ENST00000373347.1	-	3	443	c.175C>T	c.(175-177)Cct>Tct	p.P59S	DLGAP3_ENST00000235180.4_Missense_Mutation_p.P59S|DLGAP3_ENST00000495979.1_5'UTR			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	59					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GGCCCTTCAGGAGAAATGTGT	0.711000													3	7					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99305460	99305460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99305460G>A	ENST00000336374.2	-	12	1393	c.1391C>T	c.(1390-1392)tCc>tTc	p.S464F		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	464					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					AGGTTTGAAGGAGAAGTTCTG	0.348000													14	172					0	0	1	0	0
MIR518A1	574488	broad.mit.edu	37	19	54234287	54234287	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54234287C>T	ENST00000385068.1	+	0	28					NR_030210.1																						AAAGGGAAGCCCTTTCTGTTG	0.433000													48	141					0	0	1	0	0
DUSP12	11266	broad.mit.edu	37	1	161722918	161722918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161722918C>T	ENST00000367943.4	+	5	760	c.728C>T	c.(727-729)cCt>cTt	p.P243L	DUSP12_ENST00000484291.1_3'UTR	NM_007240.1	NP_009171.1	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	243					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|lung(1)	5	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			GGAAGTGGACCTATAGCCTTT	0.433000													56	136					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50683829	50683829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:50683829G>A	ENST00000442544.2	+	8	1981	c.1365G>A	c.(1363-1365)gcG>gcA	p.A455A	DCC_ENST00000581580.1_Silent_p.A110A|DCC_ENST00000412726.1_Silent_p.A303A	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	455	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTGCAGAAGCGAAAGGGAACA	0.502000													36	97					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87037411	87037411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87037411C>T	ENST00000265723.4	-	25	3332	c.3221G>A	c.(3220-3222)gGg>gAg	p.G1074E	ABCB4_ENST00000359206.3_Missense_Mutation_p.G1074E|ABCB4_ENST00000545634.1_Missense_Mutation_p.G1074E|ABCB4_ENST00000358400.3_Missense_Mutation_p.G1027E|ABCB4_ENST00000453593.1_Missense_Mutation_p.G1027E	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	1074	ABC transporter 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CGTGCTCTTCCCACAGCCACT	0.557000													25	118					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75203197	75203197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:75203197G>A	ENST00000336926.6	-	8	640	c.614C>T	c.(613-615)tCc>tTc	p.S205F	HIP1_ENST00000434438.2_Missense_Mutation_p.S205F	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	205					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CATGTCCAGGGAGTTGAATAC	0.572000			T	PDGFRB	CMML								14	30					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81122553	81122553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:81122553G>A	ENST00000339711.4	+	9	1560	c.329G>A	c.(328-330)gGa>gAa	p.G110E	PRDM8_ENST00000504452.1_Missense_Mutation_p.G110E|PRDM8_ENST00000415738.2_Missense_Mutation_p.G110E	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	110	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						ATAAAAAACGGACAGCTGTTC	0.502000													17	58					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90349346	90349346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90349346C>T	ENST00000300060.6	-	2	782	c.469G>A	c.(469-471)Gag>Aag	p.E157K		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	157	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding	p.E157Q(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TCGGTGGGCTCCACCAGCTCA	0.617000													22	103					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27685247	27685247	+	Missense_Mutation	SNP	G	G	A	rs146598623		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27685247G>A	ENST00000374040.3	-	18	2772	c.2512C>T	c.(2512-2514)Cgc>Tgc	p.R838C	MAP3K6_ENST00000357582.2_Missense_Mutation_p.R846C|MAP3K6_ENST00000493901.1_Missense_Mutation_p.R846C			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	846	Protein kinase.				activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AAGGGGGGGCGACCTGTGGCC	0.617000													23	45					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728090	20728090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20728090G>A	ENST00000427401.4	-	4	1013	c.919C>T	c.(919-921)Cat>Tat	p.H307Y		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	307					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TCTCCGCTATGAATTATCTTA	0.408000													20	56					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90503026	90503026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90503026G>A	ENST00000325643.5	+	4	3690	c.3624G>A	c.(3622-3624)agG>agA	p.R1208R		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		AGGCCCACAGGAGGCCCAGAA	0.642000													6	10					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893670	36893670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36893670C>T	ENST00000301807.6	-	13	4831	c.2934G>A	c.(2932-2934)agG>agA	p.R978R	TRANK1_ENST00000429976.2_Silent_p.R1528R|TRANK1_ENST00000428977.2_Silent_p.R978R	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1528					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCTGAGTTTTCCTTTTATTCC	0.428000													21	48					0	0	1	0	0
FITM1	161247	broad.mit.edu	37	14	24601911	24601911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24601911C>T	ENST00000267426.5	+	2	1047	c.758C>T	c.(757-759)gCc>gTc	p.A253V	FITM1_ENST00000559294.1_Missense_Mutation_p.A57V	NM_203402.2	NP_981947.1	A5D6W6	FITM1_HUMAN	fat storage-inducing transmembrane protein 1	253					lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11						GTGGTGGGCGCCGCAGTGGGC	0.602000													30	68					0	0	1	0	0
SHE	126669	broad.mit.edu	37	1	154471640	154471640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154471640G>A	ENST00000304760.2	-	2	752	c.666C>T	c.(664-666)gtC>gtT	p.V222V		NM_001010846.2	NP_001010846.1	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	222										breast(4)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	14	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CGTTCTCTCCGACTCTCTCTG	0.433000													30	74					0	0	1	0	0
TGM1	7051	broad.mit.edu	37	14	24730968	24730968	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24730968G>A	ENST00000206765.6	-	3	564	c.441C>T	c.(439-441)ttC>ttT	p.F147F	TGM1_ENST00000544573.1_Intron	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	147					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GGAGCATATGGAAAGGCTGCC	0.592000													13	127					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48312163	48312163	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48312163C>T	ENST00000435803.1	+	17	2924	c.2900C>T	c.(2899-2901)tCa>tTa	p.S967L		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	967					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ATTTATTCTTCATTTTACCGA	0.308000													27	51					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136536721	136536721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136536721C>T	ENST00000371872.4	-	18	2519	c.2262G>A	c.(2260-2262)gcG>gcA	p.A754A	SARDH_ENST00000371868.1_Silent_p.A182A|SARDH_ENST00000422262.2_Silent_p.A586A|SARDH_ENST00000439388.1_Silent_p.A754A	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	754					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GCTTGGCACCCGCGGCCATCA	0.662000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179605338	179605338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179605338C>T	ENST00000589042.1	-	48	12846	c.12622G>A	c.(12622-12624)Gaa>Aaa	p.E4208K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E3891K|TTN_ENST00000342175.6_Missense_Mutation_p.E4037K|TTN_ENST00000359218.5_Missense_Mutation_p.E3970K|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E3845K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3891							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTCAGGTTCAGCTAATAAA	0.388000													30	76					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47945211	47945211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47945211C>T	ENST00000402813.3	-	7	785	c.643G>A	c.(643-645)Gat>Aat	p.D215N	CNGA1_ENST00000514170.1_Missense_Mutation_p.D146N|CNGA1_ENST00000544810.1_Missense_Mutation_p.D146N|CNGA1_ENST00000420489.2_Missense_Mutation_p.D146N|CNGA1_ENST00000358519.4_Missense_Mutation_p.D146N			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	146					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						TCtttcttatctttgcttttc	0.328000													12	37					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210595030	210595030	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:210595030C>A	ENST00000360351.4	+	15	5899	c.5393C>A	c.(5392-5394)tCc>tAc	p.S1798Y	MAP2_ENST00000361559.4_Missense_Mutation_p.S442Y|MAP2_ENST00000392194.1_Missense_Mutation_p.S442Y|MAP2_ENST00000447185.1_Missense_Mutation_p.S1794Y|MAP2_ENST00000199940.6_Missense_Mutation_p.S530Y	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1798					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGCAATGTCTCCTCGTCTGGA	0.547000													11	49					0.00829132	0.00829501	1	1	0
TPCN1	53373	broad.mit.edu	37	12	113704138	113704138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113704138C>T	ENST00000550785.1	+	5	776	c.607C>T	c.(607-609)Ccc>Tcc	p.P203S	TPCN1_ENST00000392569.4_Missense_Mutation_p.P63S|TPCN1_ENST00000541517.1_Missense_Mutation_p.P203S|TPCN1_ENST00000335509.6_Missense_Mutation_p.P131S	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	131						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						CCCCGCCGTCCCCGCACTCCG	0.632000													127	255					0	0	1	0	0
PLGLA	285189	broad.mit.edu	37	2	107002817	107002817	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107002817G>A	ENST00000484422.1	+	0	49																											CTGGGGGCAGGAAGCAGAGAA	0.483000													96	231					0	0	1	0	0
AKT1	207	broad.mit.edu	37	14	105239822	105239822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105239822C>T	ENST00000554581.1	-	8	2278	c.798G>A	c.(796-798)tcG>tcA	p.S266S	AKT1_ENST00000402615.2_Silent_p.S266S|AKT1_ENST00000407796.2_Silent_p.S266S|AKT1_ENST00000555528.1_Silent_p.S266S|AKT1_ENST00000349310.3_Silent_p.S266S|AKT1_ENST00000554192.1_5'UTR|AKT1_ENST00000554848.1_Silent_p.S266S|AKT1_ENST00000544168.1_Silent_p.S204S			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	266	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	CGTTCTTCTCCGAGTGCAGGT	0.672000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								4	32					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56196429	56196429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56196429C>T	ENST00000361673.3	-	6	5608	c.5395G>A	c.(5395-5397)Gaa>Aaa	p.E1799K		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1799	Ig-like 2.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CCAGAGTGTTCAGGGAACATC	0.368000													16	108					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72538358	72538358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72538358G>A	ENST00000299290.1	-	6	851	c.462C>T	c.(460-462)tcC>tcT	p.S154S	TBATA_ENST00000456372.2_Silent_p.S154S|TBATA_ENST00000545575.1_Silent_p.S143S	NM_152710.2	NP_689923.2			thymus, brain and testes associated																		AGGCCACCCGGGAAGCTAGCT	0.587000													59	151					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208224719	208224719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:208224719G>A	ENST00000367033.3	-	16	3800	c.3043C>T	c.(3043-3045)Ctt>Ttt	p.L1015F		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1015	IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ACCGGGCCAAGGCCATTGGAT	0.562000													13	37					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13766107	13766107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13766107C>T	ENST00000265104.4	-	59	10183	c.10079G>A	c.(10078-10080)gGg>gAg	p.G3360E	DNAH5_ENST00000504001.3_Intron	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3360	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TAAAAAGTTCCCTGCAGTCAT	0.428000									Kartagener syndrome				23	142					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817564	4817564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4817564G>A	ENST00000248244.5	-	2	1055	c.826C>T	c.(826-828)Ccc>Tcc	p.P276S		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	276	Pro-rich.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GCCACTTCGGGAAGCCCAGGA	0.662000													16	28					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369660	56369660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56369660G>A	ENST00000301295.6	+	3	1323	c.901G>A	c.(901-903)Gga>Aga	p.G301R	NLRP4_ENST00000587891.1_Missense_Mutation_p.G226R|NLRP4_ENST00000346986.5_Missense_Mutation_p.G301R	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	301	NACHT.						ATP binding	p.G301R(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCAGCCCCGGGGATTCAACGA	0.512000													21	66					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372173	126372173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126372173C>T	ENST00000394329.3	+	9	10015	c.10002C>T	c.(10000-10002)caC>caT	p.H3334H	FAT4_ENST00000335110.5_Silent_p.H1632H	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3334	Cadherin 32.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGGAGGTACACTATTTGATTT	0.378000													28	142					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15636352	15636352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15636352C>T	ENST00000269703.2	+	3	404	c.205C>T	c.(205-207)Ctg>Ttg	p.L69L	CYP4F22_ENST00000601005.2_Silent_p.L69L	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	69						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						CAACTGGCTGCTGGGCCACCT	0.672000													17	37					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120980043	120980043	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120980043C>T	ENST00000392793.1	+	4	593	c.322C>T	c.(322-324)Cga>Tga	p.R108*	TECTA_ENST00000264037.2_Nonsense_Mutation_p.R108*			O75443	TECTA_HUMAN	tectorin alpha	108	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CAATGGAATTCGAGGCGAGAT	0.507000													24	46					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1418203	1418203	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1418203C>T	ENST00000345913.4	+	2	114	c.23C>T	c.(22-24)tCt>tTt	p.S8F	TPO_ENST00000337415.3_Missense_Mutation_p.S8F|TPO_ENST00000382269.3_Missense_Mutation_p.S8F|TPO_ENST00000497517.2_Intron|TPO_ENST00000346956.3_Missense_Mutation_p.S8F|TPO_ENST00000349624.3_Missense_Mutation_p.S8F|TPO_ENST00000382201.3_Missense_Mutation_p.S8F|TPO_ENST00000329066.4_Missense_Mutation_p.S8F|TPO_ENST00000382198.1_Missense_Mutation_p.S8F|TPO_ENST00000539820.1_Missense_Mutation_p.S8F	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	8					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCTGTGCTGTCTGTCACGCTG	0.507000													13	28					0	0	1	0	0
GBP1P1	400759	broad.mit.edu	37	1	89889957	89889957	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89889957G>A	ENST00000513638.1	+	0	698					NR_003133.2																						GATGGAGAGCGACAGGGTCCA	0.443000													99	354					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200957929	200957929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200957929G>A	ENST00000332129.2	-	22	3579	c.3263C>T	c.(3262-3264)cCc>cTc	p.P1088L	KIF21B_ENST00000360529.5_Missense_Mutation_p.P1088L|KIF21B_ENST00000461742.2_Missense_Mutation_p.P1088L|KIF21B_ENST00000422435.2_Missense_Mutation_p.P1088L	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1088					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CTGCAGCTCGGGGTGAGCTTC	0.627000													13	30					0	0	1	0	0
ZNF486	90649	broad.mit.edu	37	19	20278139	20278139	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20278139G>A	ENST00000335117.8	+	0	57				CTC-260E6.6_ENST00000593655.1_RNA|CTC-260E6.6_ENST00000586657.1_RNA|ZNF486_ENST00000597083.1_De_novo_Start_InFrame	NM_052852.3	NP_443084.2	Q96H40	ZN486_HUMAN	zinc finger protein 486						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11						CCACAGCCAAGATGCCGGGAC	0.582000													13	77					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240341341	240341341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240341341G>A	ENST00000319653.9	+	3	2133	c.1903G>A	c.(1903-1905)Gaa>Aaa	p.E635K	RP11-567G24.3_ENST00000412311.1_RNA|RP11-567G24.3_ENST00000444308.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	635					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCCCGATGAGGAACACAGGCT	0.473000													19	62					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6977581	6977581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6977581G>A	ENST00000278319.5	+	7	1961	c.1373G>A	c.(1372-1374)gGa>gAa	p.G458E	ZNF215_ENST00000529903.1_Intron|ZNF215_ENST00000414517.2_Missense_Mutation_p.G458E	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	458					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CTCCATTTTGGAAACAATTTC	0.393000													19	70					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170096247	170096247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170096247G>A	ENST00000263816.3	-	26	4369	c.4084C>T	c.(4084-4086)Cac>Tac	p.H1362Y		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1362	EGF-like 5.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACACACTCGTGAGTACAACCA	0.383000													26	69					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283247	152283247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152283247C>T	ENST00000368799.1	-	3	4150	c.4115G>A	c.(4114-4116)gGc>gAc	p.G1372D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1372	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGCCCAATGCCTGAGTGTCT	0.537000									Ichthyosis				213	560					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720094	140720094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140720094C>T	ENST00000394576.2	+	1	1556	c.1556C>T	c.(1555-1557)tCc>tTc	p.S519F	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACTGCGCTCCTTTGATTAT	0.507000													68	117					0	0	1	0	0
TBXA2R	6915	broad.mit.edu	37	19	3600303	3600303	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3600303G>A	ENST00000375190.4	-	2	723	c.330C>T	c.(328-330)gtC>gtT	p.V110V	TBXA2R_ENST00000411851.3_Silent_p.V110V|TBXA2R_ENST00000589966.1_Silent_p.V110V	NM_001060.5|NM_201636.2	NP_001051.1|NP_963998.2	P21731	TA2R_HUMAN	thromboxane A2 receptor	110					platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	AGATCATGACGACGCCCATGA	0.692000													19	37					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112358338	112358338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112358338G>A	ENST00000206423.3	-	2	1368	c.415C>T	c.(415-417)Ccc>Tcc	p.P139S	CCDC80_ENST00000439685.2_Missense_Mutation_p.P139S|CCDC80_ENST00000475181.1_5'UTR	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	139										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						AGGATGTTGGGAGAGCTGGAC	0.572000													8	127					0	0	1	0	0
ASCL1	429	broad.mit.edu	37	12	103352675	103352675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:103352675C>T	ENST00000266744.3	+	1	1212	c.653C>T	c.(652-654)tCt>tTt	p.S218F		NM_004316.3	NP_004307.2	P50553	ASCL1_HUMAN	achaete-scute family bHLH transcription factor 1	218					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			NS(3)|large_intestine(1)|lung(1)	5						GACGAGGGCTCTTACGACCCG	0.632000													14	41					0	0	1	0	0
BANF2	140836	broad.mit.edu	37	20	17705763	17705763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:17705763C>T	ENST00000246090.5	+	3	355	c.93C>T	c.(91-93)ctC>ctT	p.L31L	BANF2_ENST00000545418.2_Silent_p.L38L|BANF2_ENST00000377805.3_Silent_p.L31L	NM_178477.4	NP_848572.3	Q9H503	BAFL_HUMAN	barrier to autointegration factor 2	31						cytoplasm|nucleus	DNA binding			large_intestine(1)|lung(1)|prostate(3)|skin(1)	6						GCCATGAGCTCGCGATCAATT	0.493000													19	88					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241555917	241555917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241555917C>T	ENST00000270364.7	+	3	526	c.386C>T	c.(385-387)tCa>tTa	p.S129L	GPR35_ENST00000319838.5_5'UTR|GPR35_ENST00000403859.1_5'UTR|GPR35_ENST00000438013.2_5'UTR			Q9HC96	CAN10_HUMAN	calpain 10	0	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		tccgatacttcaccagattca	0.522000													141	266					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10645331	10645331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10645331C>T	ENST00000547195.1	-	9	1668	c.1168G>A	c.(1168-1170)Gaa>Aaa	p.E390K	MRVI1_ENST00000541483.1_Missense_Mutation_p.E275K|MRVI1_ENST00000421747.1_Missense_Mutation_p.E472K|MRVI1_ENST00000423302.2_Missense_Mutation_p.E481K|MRVI1_ENST00000436272.1_Missense_Mutation_p.E454K|MRVI1_ENST00000534266.2_Missense_Mutation_p.E166K|MRVI1_ENST00000424001.1_Missense_Mutation_p.E166K|MRVI1_ENST00000531107.1_Missense_Mutation_p.E473K|MRVI1_ENST00000527509.2_Missense_Mutation_p.E390K|MRVI1_ENST00000558540.1_Missense_Mutation_p.E166K|MRVI1_ENST00000552103.1_Missense_Mutation_p.E390K|MRVI1_ENST00000545852.1_Missense_Mutation_p.E166K	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	454					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTACCTTTTTCCTGCTCAGCT	0.468000													19	72					0	0	1	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389971	150389971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150389971G>A	ENST00000223293.5	+	3	691	c.597G>A	c.(595-597)atG>atA	p.M199I		NM_015660.2	NP_056475.1	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	199						integral to membrane	GTP binding			kidney(1)|large_intestine(1)|lung(8)|skin(2)|urinary_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGAACTAATGGACTGTATTG	0.468000													34	159					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450252	105450252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105450252C>T	ENST00000337685.2	+	5	1612	c.827C>T	c.(826-828)tCa>tTa	p.S276L	MUM1L1_ENST00000357175.2_Missense_Mutation_p.S276L|MUM1L1_ENST00000372552.1_Missense_Mutation_p.S276L	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	276										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						TCTGCTTTCTCAGAGAATATT	0.488000													9	11					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215876180	215876180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215876180C>T	ENST00000272895.7	-	17	2534	c.2315G>A	c.(2314-2316)gGa>gAa	p.G772E	ABCA12_ENST00000389661.4_Missense_Mutation_p.G454E	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	772					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity	p.G772E(1)		NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TATGGGAATTCCATATTTTGA	0.343000													17	39					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105963467	105963467	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105963467G>A	ENST00000357060.3	-	8	1173	c.1058C>T	c.(1057-1059)tCt>tTt	p.S353F	WDR96_ENST00000428666.1_Missense_Mutation_p.S354F|WDR96_ENST00000278064.2_Missense_Mutation_p.S284F|WDR96_ENST00000369720.1_Missense_Mutation_p.S284F|WDR96_ENST00000369719.1_Missense_Mutation_p.S284F	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	353										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						ATAATTGGGAGAAAATGTCAT	0.313000													29	57					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10384494	10384494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10384494C>T	ENST00000397077.1	-	18	3299	c.2724G>A	c.(2722-2724)aaG>aaA	p.K908K	ATP2B2_ENST00000383800.4_Silent_p.K908K|ATP2B2_ENST00000360273.2_Silent_p.K953K|ATP2B2_ENST00000352432.4_Silent_p.K953K|ATP2B2_ENST00000343816.4_Silent_p.K939K			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	953					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CCAGGATGTTCTTCATCATGG	0.632000													6	53					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27157868	27157868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27157868C>T	ENST00000380036.4	+	2	534	c.92C>T	c.(91-93)tCc>tTc	p.S31F	TEK_ENST00000519097.1_Intron|TEK_ENST00000406359.4_Missense_Mutation_p.S31F	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	31					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TTGATCAATTCCCTACCTCTT	0.458000													78	168					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64644097	64644097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:64644097C>T	ENST00000371079.1	+	9	2748	c.2373C>T	c.(2371-2373)ttC>ttT	p.F791F	ROR1_ENST00000545203.1_Silent_p.F242F	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	791	Pro-rich.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						ATTACATGTTCCCGAGCCAGG	0.507000													26	96					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100686795	100686795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100686795C>T	ENST00000306151.4	+	3	12162	c.12098C>T	c.(12097-12099)aCa>aTa	p.T4033I		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4033						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCAACCAGTACACCTCACACC	0.527000													60	174					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72233977	72233977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:72233977G>A	ENST00000340726.3	-	6	1049	c.410C>T	c.(409-411)tCc>tTc	p.S137F	EYA1_ENST00000388742.4_Missense_Mutation_p.S137F|EYA1_ENST00000388741.2_Missense_Mutation_p.S103F|EYA1_ENST00000303824.7_Missense_Mutation_p.S136F|EYA1_ENST00000419131.1_Missense_Mutation_p.S137F|EYA1_ENST00000388743.2_Missense_Mutation_p.S136F|EYA1_ENST00000388740.3_Missense_Mutation_p.S104F	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	137					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ACCATATGAGGAAATGCCGTA	0.488000													14	34					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249533	52249533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52249533G>A	ENST00000595042.1	-	3	856	c.715C>T	c.(715-717)Ccc>Tcc	p.P239S	FPR1_ENST00000304748.4_Missense_Mutation_p.P239S	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	239					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	ACCCGTAAGGGACGACTGGAC	0.507000													19	48					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873950	36873950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36873950C>T	ENST00000301807.6	-	21	7239	c.5342G>A	c.(5341-5343)gGg>gAg	p.G1781E	TRANK1_ENST00000429976.2_Missense_Mutation_p.G2331E|TRANK1_ENST00000428977.2_Missense_Mutation_p.G1781E	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2331					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCTGCCTCTCCCCCTGCCCCT	0.502000													52	111					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1574994	1574994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1574994C>T	ENST00000421627.2	+	4	1425	c.1291C>T	c.(1291-1293)Cgg>Tgg	p.R431W		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	510					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ATTCCGCTCCCGGAACCAGAG	0.627000													5	9					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31155072	31155072	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31155072C>T	ENST00000268281.4	-	7	865	c.807G>A	c.(805-807)cgG>cgA	p.R269R	PRSS36_ENST00000569305.1_Silent_p.R269R|PRSS36_ENST00000418068.2_Silent_p.R269R	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	269	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						GGCGGTTTCTCCGTCCACAGC	0.612000													16	53					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622450	74622450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74622450C>T	ENST00000156626.7	-	6	1535	c.1336G>A	c.(1336-1338)Gaa>Aaa	p.E446K		NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	446					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						CGGGTGCCTTCCAGGAAGTGC	0.557000													22	54					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106066502	106066502	+	RNA	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106066502T>C	ENST00000577108.1	-	0	44				IGHE_ENST00000576077.1_RNA																							TCTGCTCCCATTCGGCCCTGG	0.627000													7	121					0	0	1	0	0
SFXN1	94081	broad.mit.edu	37	5	174940517	174940517	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:174940517G>A	ENST00000321442.5	+	7	902	c.648G>A	c.(646-648)ggG>ggA	p.G216G		NM_022754.5	NP_073591.2	Q9H9B4	SFXN1_HUMAN	sideroflexin 1	216					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity|protein binding			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(3)	15	all_cancers(89;0.00922)|Renal(175;0.000269)|Lung NSC(126;0.00515)|all_lung(126;0.00873)	Medulloblastoma(196;0.0399)|all_neural(177;0.0663)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ACCGCTTGGGGGAGTCGGCGA	0.517000													28	57					0	0	1	0	0
MTHFD2	10797	broad.mit.edu	37	2	74438352	74438352	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74438352C>T	ENST00000394053.2	+	6	777	c.697C>T	c.(697-699)Cga>Tga	p.R233*	MTHFD2_ENST00000409804.1_Nonsense_Mutation_p.R105*|MTHFD2_ENST00000264090.4_Nonsense_Mutation_p.R131*|MTHFD2_ENST00000409601.1_Nonsense_Mutation_p.R192*|MTHFD2_ENST00000394050.3_Nonsense_Mutation_p.R69*	NM_006636.3	NP_006627.2	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	233					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	AATATCTCATCGATATACTCC	0.398000													39	127					0	0	1	0	0
CCDC134	79879	broad.mit.edu	37	22	42204930	42204930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42204930C>T	ENST00000255784.5	+	2	140	c.36C>T	c.(34-36)gtC>gtT	p.V12V	CCDC134_ENST00000402061.3_Silent_p.V12V	NM_024821.2	NP_079097.1	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134	12						extracellular region				large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						TCCTCTTTGTCCTGCTTTTGT	0.493000													19	92					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52520434	52520434	+	Missense_Mutation	SNP	G	G	A	rs142884639	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52520434G>A	ENST00000216286.5	-	5	1291	c.1292C>T	c.(1291-1293)tCg>tTg	p.S431L	NID2_ENST00000541773.1_Missense_Mutation_p.S378L	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	431						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					ATCCATTTCCGAAGGCACTGG	0.537000													41	86					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240493995	240493995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240493995G>A	ENST00000319653.9	+	11	4760	c.4530G>A	c.(4528-4530)caG>caA	p.Q1510Q	FMN2_ENST00000545751.1_Silent_p.Q106Q	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1510	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCGAGGACAGGCAGATGGCT	0.423000													19	101					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127646621	127646621	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127646621G>A	ENST00000405109.1	+	3	1552	c.1085G>A	c.(1084-1086)gGa>gAa	p.G362E	KBTBD12_ENST00000492025.1_Intron|KBTBD12_ENST00000343941.4_Missense_Mutation_p.E4K|KBTBD12_ENST00000407609.3_5'UTR|KBTBD12_ENST00000405256.1_Missense_Mutation_p.G362E			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	362										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						CATGATAGAGGAAACCAGTTT	0.368000													65	179					0	0	1	0	0
TNFSF9	8744	broad.mit.edu	37	19	6534669	6534669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6534669C>T	ENST00000245817.3	+	3	395	c.357C>T	c.(355-357)tcC>tcT	p.S119S		NM_003811.3	NP_003802.1	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily, member 9	119					apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						CAGGCGTGTCCCTGACGGGGG	0.592000													5	13					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857960	9857960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9857960G>A	ENST00000396573.2	-	14	3750	c.3441C>T	c.(3439-3441)ttC>ttT	p.F1147F	GRIN2A_ENST00000535259.1_Silent_p.F990F|GRIN2A_ENST00000404927.2_Silent_p.F1147F|GRIN2A_ENST00000562109.1_Silent_p.F1147F|GRIN2A_ENST00000330684.3_Silent_p.F1147F|GRIN2A_ENST00000396575.2_Silent_p.F1147F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1147					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGGGTCCGGGAAGTCCACGT	0.527000													32	112					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4836859	4836859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4836859G>A	ENST00000354582.6	+	52	7224	c.6874G>A	c.(6874-6876)Gga>Aga	p.G2292R	ITPR1_ENST00000456211.2_Missense_Mutation_p.G2244R|ITPR1_ENST00000443694.2_Missense_Mutation_p.G2292R|ITPR1_ENST00000423119.2_Missense_Mutation_p.G2259R|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.G2259R|ITPR1_ENST00000302640.8_Missense_Mutation_p.G2292R			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2307					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CCCGTTTAAGGGAGTCCGAGG	0.483000													10	28					0	0	1	0	0
CHIAP2	149620	broad.mit.edu	37	1	111826767	111826767	+	RNA	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111826767T>G	ENST00000369743.4	+	0	1477					NR_003928.1																						TGGACACTCCTTCCTTCTGAG	0.547000													10	23					0	0	1	0	0
CACNG2	10369	broad.mit.edu	37	22	36983516	36983516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36983516G>A	ENST00000300105.6	-	2	1272	c.291C>T	c.(289-291)ttC>ttT	p.F97F		NM_006078.3	NP_006069.1	Q9Y698	CCG2_HUMAN	calcium channel, voltage-dependent, gamma subunit 2	97					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	18						ACTCACGGAGGAAATATTCTG	0.512000													41	94					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205197796	205197796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205197796C>T	ENST00000358024.3	+	1	493	c.104C>T	c.(103-105)cCt>cTt	p.P35L		NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	35						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GACCTCCGGCCTGGGGAGACC	0.672000													17	26					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34775646	34775646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34775646G>A	ENST00000338074.2	+	8	995	c.834G>A	c.(832-834)aaG>aaA	p.K278K	EPB41L1_ENST00000373946.3_Silent_p.K247K|EPB41L1_ENST00000373950.2_Silent_p.K181K|EPB41L1_ENST00000441639.1_Silent_p.K216K|EPB41L1_ENST00000202028.5_Silent_p.K216K|EPB41L1_ENST00000373941.1_Silent_p.K278K	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	278	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					AGAATGCCAAGAAGCTTTCCA	0.537000													12	35					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102056928	102056928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102056928G>A	ENST00000318222.3	-	6	1376	c.994C>T	c.(994-996)Cca>Tca	p.P332S	PKD2L1_ENST00000353274.3_Missense_Mutation_p.P332S|PKD2L1_ENST00000338519.3_Missense_Mutation_p.P257S	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	332					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TGCCAGGATGGGATGGCACCT	0.562000													23	76					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43858486	43858486	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43858486G>A	ENST00000378009.4	+	0	363				CD177_ENST00000378012.2_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				GCCGCCAGGAGGACTTCTGCA	0.677000													27	64					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34513176	34513176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34513176G>A	ENST00000242317.4	+	16	1727	c.1556G>A	c.(1555-1557)gGa>gAa	p.G519E		NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	519					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		ACAGAGGAGGGAAAAATCTAC	0.522000									Kartagener syndrome				62	105					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51413243	51413243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51413243C>T	ENST00000266037.9	+	51	5500	c.5477C>T	c.(5476-5478)cCc>cTc	p.P1826L		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1826						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGCAGTGATCCCAATCTGTCT	0.532000													38	92					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102445	168102445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168102445G>A	ENST00000409195.1	+	9	4632	c.4543G>A	c.(4543-4545)Gaa>Aaa	p.E1515K	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1515K|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1293K|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1340					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AATGACCAAGGAAGAAATCCC	0.358000													50	100					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42940083	42940083	+	Silent	SNP	G	G	A	rs146924589	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42940083G>A	ENST00000426333.2	-	16	1902	c.1605C>T	c.(1603-1605)gcC>gcT	p.A535A	EFTUD2_ENST00000402521.3_Silent_p.A500A|EFTUD2_ENST00000591382.1_Silent_p.A535A|EFTUD2_ENST00000592576.1_Silent_p.A525A	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	535						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				GGCAGTACCTGGCCACAGAGA	0.582000													7	10					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117884974	117884974	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:117884974G>A	ENST00000439649.3	-	5	880	c.513C>T	c.(511-513)acC>acT	p.T171T	GFRA1_ENST00000355422.6_Silent_p.T176T|GFRA1_ENST00000544592.1_Silent_p.T55T|GFRA1_ENST00000369236.1_Silent_p.T171T	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	176					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		TGGTGCACGGGGTGATGTACG	0.587000													4	40					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38939413	38939413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38939413G>A	ENST00000359357.3	+	81	12100	c.11846G>A	c.(11845-11847)cGa>cAa	p.R3949Q	DNAH8_ENST00000441566.1_Missense_Mutation_p.R3913Q|DNAH8_ENST00000449981.2_Missense_Mutation_p.R4166Q					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTACATGCTCGAAAGCTGATT	0.413000													22	94					0	0	1	0	0
PLIN3	10226	broad.mit.edu	37	19	4847814	4847814	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4847814G>A	ENST00000221957.4	-	6	899	c.723C>T	c.(721-723)tcC>tcT	p.S241S	PLIN3_ENST00000592528.1_Silent_p.S229S|PLIN3_ENST00000585479.1_Silent_p.S241S	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	241					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	TCTCCGACAGGGAGCCCAGAC	0.637000													10	32					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42482807	42482807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42482807G>A	ENST00000545399.1	-	12	1773	c.1620C>T	c.(1618-1620)gcC>gcT	p.A540A	ATP1A3_ENST00000302102.5_Silent_p.A527A|ATP1A3_ENST00000602133.1_Silent_p.A497A|ATP1A3_ENST00000543770.1_Silent_p.A538A	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	527					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CATTCTGGAAGGCCTCCTTCA	0.662000													20	81					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38904723	38904723	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38904723C>A	ENST00000302328.3	-	24	4217	c.4019G>T	c.(4018-4020)gGa>gTa	p.G1340V	SCN11A_ENST00000456224.3_Missense_Mutation_p.G1302V|SCN11A_ENST00000444237.2_Missense_Mutation_p.G1340V|SCN11A_ENST00000450244.1_Missense_Mutation_p.G1340V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1340					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTTTTTGGATCCTAATTTTTT	0.348000													18	47					1.67942e-08	1.68507e-08	1	1	0
NRK	203447	broad.mit.edu	37	X	105152872	105152872	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105152872C>T	ENST00000428173.2	+	13	1545	c.1242C>T	c.(1240-1242)gcC>gcT	p.A414A	NRK_ENST00000243300.9_Silent_p.A413A			Q7Z2Y5	NRK_HUMAN	Nik related kinase	413	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						AGGGAGCAGCCAGGGTATTCA	0.587000										HNSCC(51;0.14)			16	14					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718688	140718688	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140718688G>A	ENST00000394576.2	+	1	150	c.150G>A	c.(148-150)aaG>aaA	p.K50K	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACATCGCCAAGGACTTGGGTT	0.617000											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	94					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205890756	205890756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205890756G>A	ENST00000367135.3	-	17	2106	c.1993C>T	c.(1993-1995)Ctc>Ttc	p.L665F	SLC26A9_ENST00000367134.2_Missense_Mutation_p.L665F|SLC26A9_ENST00000340781.4_Missense_Mutation_p.L665F	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	665	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TCCAGGATGAGGGTGTGGAAG	0.647000													5	19					0	0	1	0	0
C14orf119	55017	broad.mit.edu	37	14	23566952	23566952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23566952C>T	ENST00000319074.4	+	2	941	c.85C>T	c.(85-87)Cct>Tct	p.P29S	C14orf119_ENST00000554203.1_Missense_Mutation_p.P29S	NM_017924.3	NP_060394.1	Q9NWQ9	CN119_HUMAN	chromosome 14 open reading frame 119	29										central_nervous_system(1)|endometrium(1)|lung(1)	3	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00649)		CCCTTCCCCTCCTCTGATGTC	0.488000													82	201					0	0	1	0	0
LOC101929950	101929950	broad.mit.edu	37	17	36375119	36375119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:36375119G>A	ENST00000312412.4	-	3	398	c.399C>T	c.(397-399)ttC>ttT	p.F133F	RP11-1407O15.2_ENST00000544906.1_5'UTR																kidney(1)|lung(3)	4						GAGTACTAGGGAAAGACAAGG	0.348000													6	42					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71511997	71511997	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:71511997C>T	ENST00000304743.2	+	20	4461	c.4015C>T	c.(4015-4017)Cga>Tga	p.R1339*	PCNX_ENST00000439984.3_Nonsense_Mutation_p.R1228*|PCNX_ENST00000238570.5_Nonsense_Mutation_p.R1339*	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1339						integral to membrane		p.R1339*(1)		NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GTATGAAGTTCGAAGTAAGTA	0.343000													24	59					0	0	1	0	0
CCDC83	220047	broad.mit.edu	37	11	85627240	85627240	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:85627240G>A	ENST00000280245.4	+	11	1649	c.1137G>A	c.(1135-1137)atG>atA	p.M379I	CCDC83_ENST00000376067.1_Missense_Mutation_p.M248I|CCDC83_ENST00000342404.3_Missense_Mutation_p.M348I	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	348										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ACACTGATATGAAGTACTTAC	0.348000													63	112					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105105720	105105720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:105105720C>T	ENST00000436393.2	+	21	2984	c.2743C>T	c.(2743-2745)Cat>Tat	p.H915Y	RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000507740.1_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	369					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATGGGATCCTCATAGAGGGGC	0.398000										HNSCC(12;0.0054)			41	98					0	0	1	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026534	176026534	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176026534G>A	ENST00000303991.4	-	2	479	c.302C>T	c.(301-303)cCc>cTc	p.P101L		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	101						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGACTCCTGGGGAGAGAAGCA	0.647000													22	50					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128681	152128681	+	Silent	SNP	C	C	T	rs112678204		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152128681C>T	ENST00000316073.3	-	3	958	c.894G>A	c.(892-894)acG>acA	p.T298T		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	298	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CTTGTCTGTCCGTCTGACCGT	0.507000													246	674					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105252524	105252524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:105252524C>T	ENST00000306107.5	+	5	1037	c.537C>T	c.(535-537)ccC>ccT	p.P179P	ALCAM_ENST00000486979.2_Silent_p.P128P|ALCAM_ENST00000472644.2_Silent_p.P179P|ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000389927.4_5'UTR	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	179	Ig-like V-type 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						TGCTACATCCCCTTGAAGGAG	0.448000													29	90					0	0	1	0	0
APOBEC3F	200316	broad.mit.edu	37	22	39448345	39448345	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39448345C>T	ENST00000308521.5	+	6	1347	c.990C>T	c.(988-990)atC>atT	p.I330I	APOBEC3G_ENST00000452957.2_Intron	NM_145298.5	NP_660341.2	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F	337					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|skin(2)	16	Melanoma(58;0.04)					CCGTGGAGATCATGGGCTACA	0.617000													36	81					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716045	13716045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13716045G>A	ENST00000279593.3	-	13	4336	c.4127C>T	c.(4126-4128)tCg>tTg	p.S1376L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1376					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGGTAGAGCGACTTGCTGAG	0.587000													11	31					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207644806	207644806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207644806G>A	ENST00000367057.3	+	9	1721	c.1532G>A	c.(1531-1533)gGc>gAc	p.G511D	CR2_ENST00000367058.3_Missense_Mutation_p.G511D|CR2_ENST00000458541.2_Intron|CR2_ENST00000367059.3_Missense_Mutation_p.G511D	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	511	Sushi 8.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						GAGTGTCAAGGCACAATTCCT	0.403000													55	147					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143093026	143093026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:143093026G>A	ENST00000367603.2	-	5	3592	c.2850C>T	c.(2848-2850)tcC>tcT	p.S950S	HIVEP2_ENST00000012134.2_Silent_p.S950S|HIVEP2_ENST00000367604.1_Silent_p.S950S	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	950	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ACTCCCCTGAGGAGTGCTCCA	0.557000													34	52					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	124007847	124007847	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124007847C>T	ENST00000456829.2	+	15	2002	c.1751C>T	c.(1750-1752)tCc>tTc	p.S584F	VWA5A_ENST00000360334.4_Intron|VWA5A_ENST00000392748.1_Missense_Mutation_p.S584F	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	584										autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						GTCATAAGCTCCTTCACAGCT	0.502000													17	60					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110232227	110232227	+	Silent	SNP	G	G	A	rs146929022		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110232227G>A	ENST00000418703.2	-	7	1492	c.1398C>T	c.(1396-1398)ttC>ttT	p.F466F	TRPV4_ENST00000541794.1_Silent_p.F419F|TRPV4_ENST00000537083.1_Silent_p.F406F|TRPV4_ENST00000261740.2_Silent_p.F466F|TRPV4_ENST00000392719.2_Silent_p.F419F|TRPV4_ENST00000536838.1_Silent_p.F432F|TRPV4_ENST00000346520.2_Silent_p.F406F|TRPV4_ENST00000544971.1_Silent_p.F359F	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	466					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						AGACGGCCCCGAACTTGCGCC	0.602000													48	108					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66101939	66101939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:66101939G>A	ENST00000349533.6	+	20	2924	c.2739G>A	c.(2737-2739)ttG>ttA	p.L913L	LEPR_ENST00000406510.3_5'UTR	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	913					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CTCTTCTTTTGGAGCCTGAAA	0.368000													68	198					0	0	1	0	0
CIB4	130106	broad.mit.edu	37	2	26806663	26806663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26806663C>T	ENST00000288861.4	-	5	485	c.432G>A	c.(430-432)acG>acA	p.T144T	CIB4_ENST00000405346.3_5'UTR	NM_001029881.1	NP_001025052.1	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	144	EF-hand 3.						calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACACGTGGTTCGTGAGGTCCA	0.582000													15	76					0	0	1	0	0
PPP6R1	22870	broad.mit.edu	37	19	55757032	55757032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55757032G>A	ENST00000412770.2	-	3	808	c.242C>T	c.(241-243)gCc>gTc	p.A81V	PPP6R1_ENST00000587283.1_Missense_Mutation_p.A81V	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	81	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						AATCTCGCAGGCCACACTGGG	0.667000													8	22					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74007901	74007901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74007901G>A	ENST00000301607.3	-	20	2773	c.2520C>T	c.(2518-2520)gcC>gcT	p.A840A	EVPL_ENST00000586740.1_Silent_p.A862A	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	840	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GTCTCTTGGGGGCTGACACTG	0.622000													12	30					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202914163	202914163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202914163G>A	ENST00000340990.5	-	5	863	c.565C>T	c.(565-567)Ctc>Ttc	p.L189F	ADIPOR1_ENST00000436244.1_Missense_Mutation_p.L189F|ADIPOR1_ENST00000367254.3_Intron	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	189					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			GTGTGAAAGAGCCAGGAGAAG	0.448000													13	158					0	0	1	0	0
TXK	7294	broad.mit.edu	37	4	48073536	48073536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48073536C>T	ENST00000264316.4	-	14	1598	c.1513G>A	c.(1513-1515)Gag>Aag	p.E505K	TXK_ENST00000507351.1_Missense_Mutation_p.E160K	NM_003328.2	NP_003319.2	P42681	TXK_HUMAN	TXK tyrosine kinase	505	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(2)	25						ATGCTTACCTCATGCCAGCAG	0.453000													56	98					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49425842	49425842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49425842G>A	ENST00000301067.7	-	39	12645	c.12646C>T	c.(12646-12648)Cct>Tct	p.P4216S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGCTGCTGAGGACTTAAGTGC	0.622000													7	62					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126132444	126132444	+	Missense_Mutation	SNP	G	G	A	rs139824767		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126132444G>A	ENST00000373631.3	+	7	1113	c.1112G>A	c.(1111-1113)gGa>gAa	p.G371E	CRB2_ENST00000373629.2_Missense_Mutation_p.G39E|CRB2_ENST00000359999.3_Missense_Mutation_p.G371E	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	371	EGF-like 8; calcium-binding (Potential).					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						CTGCACGGCGGAACCTGCAGT	0.602000													20	59					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57869041	57869041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57869041C>T	ENST00000391705.3	+	4	2088	c.1804C>T	c.(1804-1806)Ctc>Ttc	p.L602F	ZNF304_ENST00000598744.1_Missense_Mutation_p.L560F|ZNF304_ENST00000443917.2_Missense_Mutation_p.L649F|ZNF304_ENST00000282286.5_Missense_Mutation_p.L602F	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	602					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CAACTCTGGCCTCATTCTGCA	0.478000													32	68					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895665	90895665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:90895665C>T	ENST00000287934.2	+	1	1883	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	490					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding	p.F490F(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGCGTGGCTTCGTGCTGGCGC	0.612000													75	188					0	0	1	0	0
OR1L3	26735	broad.mit.edu	37	9	125437994	125437994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125437994G>A	ENST00000304820.2	+	1	680	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						CTTTGTCAATGAAATTGTGGC	0.433000													56	197					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21252800	21252800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21252800C>T	ENST00000233242.1	-	11	1567	c.1440G>A	c.(1438-1440)ggG>ggA	p.G480G	APOB_ENST00000399256.4_Silent_p.G480G	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	480	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATCTTCATCCCCAGTGCAGT	0.418000													48	160					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72509738	72509738	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72509738C>T	ENST00000373208.1	+	16	2433	c.2433C>T	c.(2431-2433)atC>atT	p.I811I	ADAMTS14_ENST00000373207.1_Silent_p.I808I	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	808	Spacer.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CCATTGCCATCCTGGTGAGCC	0.642000													11	56					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383994	108383994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108383994G>A	ENST00000265843.4	-	6	2350	c.2240C>T	c.(2239-2241)tCc>tTc	p.S747F	EXPH5_ENST00000428840.1_Missense_Mutation_p.S671F|EXPH5_ENST00000443411.1_Missense_Mutation_p.S559F|EXPH5_ENST00000525344.1_Missense_Mutation_p.S740F	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	747					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGAGTCCTGGGATAAGGGATT	0.423000													42	87					0	0	1	0	0
PLGLA	285189	broad.mit.edu	37	2	107002828	107002828	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107002828G>A	ENST00000484422.1	+	0	60																											AAGCAGAGAAGAATGTGCAGC	0.473000													66	276					0	0	1	0	0
REG3G	130120	broad.mit.edu	37	2	79253856	79253856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79253856G>A	ENST00000272324.5	+	3	278	c.94G>A	c.(94-96)Gaa>Aaa	p.E32K	REG3G_ENST00000393897.2_Missense_Mutation_p.E32K|REG3G_ENST00000409471.1_Missense_Mutation_p.E32K	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	32					acute-phase response	extracellular region	sugar binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AACCCAGAAGGAACTGCCCTC	0.532000													20	49					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032146	26032146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26032146G>A	ENST00000244661.2	-	1	142	c.143C>T	c.(142-144)gCt>gTt	p.A48V		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	48					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						CTCGCGCAGAGCCACAGTGCC	0.632000													35	148					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162505	33162505	+	RNA	SNP	C	C	T	rs146818486	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33162505C>T	ENST00000510327.1	-	0	346																											GTGTTGTACTCGTAAAACAAG	0.502000													20	56					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130319437	130319437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130319437C>T	ENST00000299164.2	+	1	569	c.569C>T	c.(568-570)cCt>cTt	p.P190L		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	190					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GCCCTGGACCCTTACAAGCCG	0.726000													5	5					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	122075601	122075601	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:122075601G>A	ENST00000265922.3	-	2	494	c.33C>T	c.(31-33)ttC>ttT	p.F11F	DBC1_ENST00000373964.2_Silent_p.F11F	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		11					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						ATATAAACAGGAAGTAGAGGA	0.473000													15	54					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168861618	168861618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168861618G>A	ENST00000264674.3	-	3	144	c.6C>T	c.(4-6)atC>atT	p.I2I	MECOM_ENST00000433243.2_5'UTR|MECOM_ENST00000472280.1_5'UTR|MECOM_ENST00000464456.1_5'UTR|MECOM_ENST00000392736.3_5'UTR|MECOM_ENST00000494292.1_Silent_p.I126I|MECOM_ENST00000468789.1_5'UTR	NM_001105077.3	NP_001098547.3	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						ATTCGTCTAAGATCTGGAGGG	0.373000													25	133					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74092095	74092095	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:74092095C>T	ENST00000443185.2	-	4	2292	c.1975G>A	c.(1975-1977)Gag>Aag	p.E659K	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	659					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTAGAAGTCTCTCTGCTACTG	0.522000													24	51					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554457	135554457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135554457C>T	ENST00000372146.4	+	2	2015	c.1451C>T	c.(1450-1452)cCc>cTc	p.P484L	GTF3C4_ENST00000483873.2_3'UTR	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	484					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GCAGTGAGCCCCTGCGGTGCA	0.473000													7	77					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979793	12979793	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12979793G>T	ENST00000361079.2	+	4	1068	c.985G>T	c.(985-987)Gtc>Ttc	p.V329F						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCTGAGGGGTGTCACGCTGAC	0.572000													14	128					1.49906e-05	1.50184e-05	1	1	0
MYH7B	57644	broad.mit.edu	37	20	33577900	33577900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33577900G>A	ENST00000262873.7	+	19	2069	c.1977G>A	c.(1975-1977)caG>caA	p.Q659Q		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	617	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity	p.Q659H(1)		NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGAAGTCACAGAATAGGCTCC	0.547000													55	103					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699168	52699168	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52699168G>A	ENST00000293525.5	+	5	932	c.880G>A	c.(880-882)Gag>Aag	p.E294K	KRT86_ENST00000544024.1_Missense_Mutation_p.E294K|KRT86_ENST00000423955.2_Missense_Mutation_p.E294K	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	294	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		GGCTGAGGCCGAGTCCTGGTA	0.537000													25	85					0	0	1	0	0
MYL4	4635	broad.mit.edu	37	17	45299052	45299052	+	Missense_Mutation	SNP	G	G	A	rs138156448		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45299052G>A	ENST00000354968.1	+	5	446	c.318G>A	c.(316-318)atG>atA	p.M106I	MYL4_ENST00000393450.1_Missense_Mutation_p.M106I|MYL4_ENST00000572316.1_Missense_Mutation_p.M106I	NM_001002841.1	NP_001002841.1	P12829	MYL4_HUMAN	myosin, light chain 4, alkali; atrial, embryonic	106					cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			endometrium(2)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)	11						CTGAAGAGATGAATGTCAAGA	0.547000													48	55					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89925077	89925077	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89925077T>G	ENST00000405460.2	+	9	1656	c.1560T>G	c.(1558-1560)ttT>ttG	p.F520L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	520					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAATAACATTTTTTCCTATGG	0.373000													9	30					0	0	1	0	0
TDP1	55775	broad.mit.edu	37	14	90485726	90485726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90485726C>T	ENST00000335725.4	+	15	1858	c.1608C>T	c.(1606-1608)tcC>tcT	p.S536S	TDP1_ENST00000555880.1_Silent_p.S536S|TDP1_ENST00000393454.2_Silent_p.S536S|TDP1_ENST00000393452.3_Silent_p.S536S|TDP1_ENST00000357382.3_Silent_p.S297S	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	536					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGATCCGCTCCTACGAGCTCG	0.522000								Repair of DNA-protein crosslinks					10	46					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201063042	201063042	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201063042C>T	ENST00000362061.3	-	3	592	c.366G>A	c.(364-366)tgG>tgA	p.W122*	CACNA1S_ENST00000367338.3_Nonsense_Mutation_p.W122*	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	122					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCAGCACATTCCAGCCACTGC	0.547000													24	61					0	0	1	0	0
PAQR7	164091	broad.mit.edu	37	1	26189653	26189653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26189653G>A	ENST00000374296.3	-	2	1344	c.678C>T	c.(676-678)ttC>ttT	p.F226F	RP1-125I3.2_ENST00000455431.1_RNA	NM_178422.5	NP_848509.1	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	226					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		CGGAGGACACGAAGATACGAT	0.577000													29	63					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449186	104449186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104449186C>T	ENST00000361820.3	-	2	1596	c.996G>A	c.(994-996)atG>atA	p.M332I		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	332					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GGATACTTTCCATGTCGCAGC	0.517000													13	41					0	0	1	0	0
SSUH2	51066	broad.mit.edu	37	3	8673774	8673774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:8673774C>T	ENST00000317371.4	-	12	1520	c.295G>A	c.(295-297)Gaa>Aaa	p.E99K	SSUH2_ENST00000544814.1_Missense_Mutation_p.E121K|SSUH2_ENST00000341795.3_Missense_Mutation_p.E99K|SSUH2_ENST00000415132.1_Missense_Mutation_p.E99K					ssu-2 homolog (C. elegans)																		ATCCTGGATTCACTAAAGGTC	0.413000													27	74					0	0	1	0	0
SERPINE1	5054	broad.mit.edu	37	7	100777118	100777118	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100777118C>T	ENST00000223095.4	+	5	1000	c.843C>T	c.(841-843)ctC>ctT	p.L281L	SERPINE1_ENST00000445463.2_Silent_p.L266L	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	281				QLI -> HVM (in Ref. 7; CAA31208).	angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GTGCCCAGCTCATCAGCCACT	0.587000													26	77					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77425034	77425034	+	Missense_Mutation	SNP	G	G	A	rs148023800	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:77425034G>A	ENST00000255194.6	-	16	1923	c.1748C>T	c.(1747-1749)cCg>cTg	p.P583L	AP3B1_ENST00000519295.1_Missense_Mutation_p.P534L	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	583					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		CTTTACATTCGGAACAATAAG	0.368000									Hermansky-Pudlak syndrome				20	62					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86415927	86415927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86415927C>T	ENST00000361669.2	+	3	1918	c.819C>T	c.(817-819)gtC>gtT	p.V273V	AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000394720.2_Silent_p.V271V|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Silent_p.V273V|GRM3_ENST00000536043.1_Silent_p.V145V	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	273					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCGTCGTGGTCCTCTTCATGC	0.672000													8	74					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204939824	204939824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204939824G>A	ENST00000367172.4	+	11	1412	c.1084G>A	c.(1084-1086)Gga>Aga	p.G362R	NFASC_ENST00000513543.1_Missense_Mutation_p.G373R|NFASC_ENST00000338586.6_Missense_Mutation_p.G362R|NFASC_ENST00000367169.4_Missense_Mutation_p.G362R|NFASC_ENST00000360049.4_Missense_Mutation_p.G373R|NFASC_ENST00000367171.4_Missense_Mutation_p.G362R|NFASC_ENST00000401399.1_Missense_Mutation_p.G362R|NFASC_ENST00000539706.1_Missense_Mutation_p.G373R|NFASC_ENST00000403080.1_Missense_Mutation_p.G362R|NFASC_ENST00000367170.4_Missense_Mutation_p.G362R|NFASC_ENST00000339876.6_Missense_Mutation_p.G362R|NFASC_ENST00000404907.1_Missense_Mutation_p.G373R|NFASC_ENST00000404076.1_Missense_Mutation_p.G356R|NFASC_ENST00000338515.6_Missense_Mutation_p.G362R			O94856	NFASC_HUMAN	neurofascin	362	Ig-like C2-type 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCGAGCCAATGGAAACCCCAA	0.532000													30	59					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179582503	179582503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179582503C>T	ENST00000589042.1	-	87	25322	c.25098G>A	c.(25096-25098)ctG>ctA	p.L8366L	TTN_ENST00000342992.6_Silent_p.L7122L|TTN_ENST00000591111.1_Silent_p.L8049L|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8049	Ig-like 66.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAACGTCTTTCAGTTTTCTTG	0.418000													7	26					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130789654	130789654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:130789654G>A	ENST00000276708.4	-	2	1061	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	60						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CATTGAGGGAGAATTCAACTG	0.423000													22	52					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48312489	48312489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48312489C>T	ENST00000435803.1	+	17	3250	c.3226C>T	c.(3226-3228)Cgt>Tgt	p.R1076C		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1076					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGAAGATTTTCGTATTTCTTT	0.378000													7	14					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7527128	7527128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7527128C>T	ENST00000313599.3	-	13	3376	c.3319G>A	c.(3319-3321)Gga>Aga	p.G1107R	CD163L1_ENST00000396630.1_Missense_Mutation_p.G1107R|CD163L1_ENST00000416109.2_Missense_Mutation_p.G1117R			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1107	SRCR 10.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GACTCCATTCCTGTGCAGTTC	0.622000													34	71					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2946452	2946452	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2946452C>T	ENST00000396946.4	-	25	3688	c.3285G>A	c.(3283-3285)acG>acA	p.T1095T		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1095	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		ACTCCTCCTCCGTCTCAGGTC	0.682000			Mis		DLBCL								16	24					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9333729	9333729	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:9333729C>T	ENST00000261336.2	-	15	1718		c.e15-1		PZP_ENST00000381997.2_Splice_Site	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TCAAATCCACCTGTGGGAAAT	0.522000													6	38					0	0	1	0	0
KIR2DL3	3804	broad.mit.edu	37	19	55263177	55263177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55263177C>T	ENST00000342376.3	+	6	823	c.792C>T	c.(790-792)ctC>ctT	p.L264L	KIR3DL1_ENST00000541392.1_Intron|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL4_ENST00000396284.2_Intron	NM_015868.2	NP_056952.2			killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3											breast(1)|cervix(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		tcttctttctccttcATCGCT	0.522000													49	46					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44222779	44222779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44222779G>A	ENST00000244314.5	+	2	268	c.69G>A	c.(67-69)agG>agA	p.R23R		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	23						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CCAAGGAAAGGCTGGAGGCCC	0.642000													40	85					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3855571	3855571	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3855571G>A	ENST00000520002.1	-	5	1227	c.672C>T	c.(670-672)ttC>ttT	p.F224F	CSMD1_ENST00000542608.1_Silent_p.F224F|CSMD1_ENST00000400186.3_Silent_p.F224F|CSMD1_ENST00000602557.1_Silent_p.F224F|CSMD1_ENST00000537824.1_Silent_p.F224F|CSMD1_ENST00000602723.1_Silent_p.F224F|CSMD1_ENST00000539096.1_Silent_p.F224F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	224	CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACTCTGAAGGGAAGTGCGGGC	0.572000													3	5					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248437012	248437012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248437012G>A	ENST00000318021.2	-	1	126	c.105C>T	c.(103-105)acC>acT	p.T35T		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CAAACAGGGAGGTCAAAACGA	0.488000													32	77					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128865607	128865607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128865607C>T	ENST00000375990.3	+	4	704	c.301C>T	c.(301-303)Cgt>Tgt	p.R101C	UGGT1_ENST00000259253.6_Missense_Mutation_p.R125C			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	125					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TCTGTCCCTTCGTTCTTACTC	0.433000													51	102					0	0	1	0	0
SDC4	6385	broad.mit.edu	37	20	43956011	43956011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43956011G>A	ENST00000372733.3	-	5	529	c.490C>T	c.(490-492)Ctg>Ttg	p.L164L	SDC4_ENST00000537976.1_Silent_p.L92L	NM_002999.3	NP_002990.2	P31431	SDC4_HUMAN	syndecan 4	164						extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity		SDC4/ROS1(7)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)	5		Myeloproliferative disorder(115;0.0122)				AGTAGGATCAGGAAGACGGCA	0.532000			T	ROS1	NSCLC								14	58					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110831646	110831646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110831646G>A	ENST00000375820.4	-	30	2437	c.2316C>T	c.(2314-2316)atC>atT	p.I772I		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	772	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CAGGGGGTCCGATCGCTCCAT	0.577000													32	81					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784861	82784861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82784861G>A	ENST00000423517.2	-	2	1433	c.1096C>T	c.(1096-1098)Ctt>Ttt	p.L366F	PCLO_ENST00000333891.8_Missense_Mutation_p.L366F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	326	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.P365_L366insRLSWRLSRTK(2)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCAGGACCAAGAGGCTGAGCT	0.577000													8	38					0	0	1	0	0
FAM117B	150864	broad.mit.edu	37	2	203630246	203630246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:203630246C>T	ENST00000303116.6	+	8	1539	c.797C>T	c.(796-798)tCt>tTt	p.S266F	FAM117B_ENST00000392238.2_Missense_Mutation_p.S510F	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	510										breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						AAAAGTGGATCTGCTTTCTGC	0.483000													37	159					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23728509	23728509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23728509C>T	ENST00000304749.2	-	3	440	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K	CST1_ENST00000398402.1_Missense_Mutation_p.E124K	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	124						extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					CAGGGAACTTCGTAGATCTCG	0.527000													31	34					0	0	1	0	0
FCGR3A	2214	broad.mit.edu	37	1	161519511	161519511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161519511G>A	ENST00000367969.3	-	1	307	c.124C>T	c.(124-126)Ctc>Ttc	p.L42F	FCGR3A_ENST00000540048.1_Intron|FCGR3A_ENST00000436743.1_Missense_Mutation_p.L6F|FCGR3A_ENST00000443193.1_Missense_Mutation_p.L42F|FCGR3A_ENST00000476031.1_5'UTR	NM_000569.6	NP_000560.5	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	6	Ig-like C2-type 1.				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCAGTTGGGAGGAGCAGCTGC	0.532000													17	49					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90816375	90816375	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:90816375C>T	ENST00000394980.1	+	2	572	c.253C>T	c.(253-255)Ccc>Tcc	p.P85S	MMRN1_ENST00000264790.2_Missense_Mutation_p.P85S|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	85					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AACACTGCCTCCCTCAGAAAC	0.478000													20	47					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93106913	93106913	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:93106913G>A	ENST00000359558.2	-	6	626	c.327C>T	c.(325-327)tcC>tcT	p.S109S	CALCR_ENST00000394441.1_Silent_p.S91S|CALCR_ENST00000421592.1_Silent_p.S91S|CALCR_ENST00000360249.4_Silent_p.S91S|CALCR_ENST00000426151.1_Silent_p.S91S	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	91					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding	p.S91S(1)|p.S109S(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	AGAACTGATAGGACAATACTC	0.423000													15	45					0	0	1	0	0
C11orf88	399949	broad.mit.edu	37	11	111385654	111385654	+	Missense_Mutation	SNP	C	C	T	rs4418847		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111385654C>T	ENST00000529167.1	+	1	145	c.145C>T	c.(145-147)Cct>Tct	p.P49S	C11orf88_ENST00000375618.4_Missense_Mutation_p.P49S|C11orf88_ENST00000332814.6_Missense_Mutation_p.P49S|RP11-794P6.6_ENST00000530283.1_RNA			Q6PI97	CK088_HUMAN	chromosome 11 open reading frame 88	49										endometrium(1)|large_intestine(3)|lung(2)	6						GATGTATCCCCCTAGCGAATC	0.597000											OREG0021329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	78					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167993	140167993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140167993G>A	ENST00000504120.2	+	1	2118	c.2118G>A	c.(2116-2118)gcG>gcA	p.A706A	PCDHA1_ENST00000378133.3_Silent_p.A706A|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATCTGCGCGGTGTCCAGCC	0.682000													35	76					0	0	1	0	0
ACD	65057	broad.mit.edu	37	16	67694215	67694215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67694215G>A	ENST00000219251.8	-	1	498	c.167C>T	c.(166-168)cCa>cTa	p.P56L	ACD_ENST00000393919.4_Missense_Mutation_p.P56L	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	56					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTCCTTCGCTGGGCGGGGCCG	0.741000													5	32					0	0	1	0	0
TFPI2	7980	broad.mit.edu	37	7	93516176	93516176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:93516176G>A	ENST00000222543.5	-	5	976	c.664C>T	c.(664-666)Cgc>Tgc	p.R222C	GNGT1_ENST00000455502.1_Intron|TFPI2_ENST00000545378.1_Missense_Mutation_p.R111C	NM_006528.3	NP_006519.1	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2	222					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity	p.R222C(1)		endometrium(1)|large_intestine(5)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			CTGGCAAAGCGAAGCTTTGGC	0.328000													48	121					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	517561	517561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:517561C>T	ENST00000453061.2	+	9	2034	c.1928C>T	c.(1927-1929)tCc>tTc	p.S643F	PIGG_ENST00000310340.5_Missense_Mutation_p.S635F|PIGG_ENST00000383028.4_Missense_Mutation_p.S510F|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000504346.1_Missense_Mutation_p.S554F	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	643					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CCCTCTACCTCCGAAGTGCTC	0.637000													15	48					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87772351	87772351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87772351C>T	ENST00000398204.4	+	15	1554	c.1231C>T	c.(1231-1233)Cct>Tct	p.P411S	ADAM22_ENST00000398201.4_Missense_Mutation_p.P411S|ADAM22_ENST00000398209.3_Missense_Mutation_p.P411S|ADAM22_ENST00000315984.7_Missense_Mutation_p.P411S|ADAM22_ENST00000265727.7_Missense_Mutation_p.P411S	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	411	Peptidase M12B.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CTATTATCTTCCTAAAAAGTT	0.343000													38	105					0	0	1	0	0
ACTC1	70	broad.mit.edu	37	15	35083487	35083487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:35083487G>A	ENST00000290378.4	-	6	1473	c.818C>T	c.(817-819)tCt>tTt	p.S273F	RP11-814P5.1_ENST00000503496.1_RNA|ACTC1_ENST00000557860.1_5'UTR	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	273					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GATGCCAGCAGATTCCATACC	0.468000													19	79					0	0	1	0	0
C8orf47	203111	broad.mit.edu	37	8	99101478	99101478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:99101478C>T	ENST00000318528.3	+	2	592	c.233C>T	c.(232-234)cCc>cTc	p.P78L	C8orf47_ENST00000545282.1_Intron	NM_173549.2	NP_775820.2	Q6P6B1	CH047_HUMAN	chromosome 8 open reading frame 47	78										kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(2)	13	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			GGTGTTAAACCCCTCCAAGAA	0.527000													30	113					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29642576	29642576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:29642576C>T	ENST00000373779.3	+	24	3555	c.3426C>T	c.(3424-3426)atC>atT	p.I1142I	PTPRU_ENST00000428026.2_Silent_p.I1139I|PTPRU_ENST00000460170.2_Silent_p.I1148I|PTPRU_ENST00000323874.8_Silent_p.I1148I|PTPRU_ENST00000345512.3_Silent_p.I1152I|PTPRU_ENST00000356870.3_Silent_p.I1148I	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1152	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		AGACCACCATCCCTGTCAGTG	0.552000													17	59					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53227577	53227577	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53227577G>A	ENST00000330553.5	-	1	502	c.468C>T	c.(466-468)ttC>ttT	p.F156F		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	156	Coil 1A.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCTTGTCGATGAAGGAGGCGA	0.607000													32	234					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4069751	4069751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:4069751C>T	ENST00000274673.3	-	7	1109	c.706G>A	c.(706-708)Gaa>Aaa	p.E236K	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	236																	GTGAAAGGTTCCTCAACATTT	0.378000													47	114					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82323694	82323694	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:82323694C>T	ENST00000376520.4	+	14	2180	c.1352C>T	c.(1351-1353)tCa>tTa	p.S451L	TLE4_ENST00000376534.4_Missense_Mutation_p.S56L|TLE4_ENST00000376537.4_Missense_Mutation_p.S451L|TLE4_ENST00000265284.6_Missense_Mutation_p.S394L|TLE4_ENST00000376544.3_Missense_Mutation_p.S350L|TLE4_ENST00000376552.2_Missense_Mutation_p.S419L			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TATGGGAGATCACCAGTGGTG	0.582000													9	25					0	0	1	0	0
SLC9A1	6548	broad.mit.edu	37	1	27436206	27436206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27436206G>A	ENST00000263980.3	-	3	1451	c.876C>T	c.(874-876)ttC>ttT	p.F292F	SLC9A1_ENST00000545949.1_5'UTR|SLC9A1_ENST00000374086.3_Silent_p.F292F	NM_003047.4	NP_003038.2	P19634	SL9A1_HUMAN	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	292					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	GGAAGCCGAGGAAGATGTCCA	0.612000													37	105					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86524856	86524856	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86524856C>T	ENST00000370571.2	-	9	2120	c.1752_splice	c.e9-1	p.G585_splice	COL24A1_ENST00000436319.1_Splice_Site_p.G585_splice	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	585	Collagen-like 2.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCCTGGAATTCCCTGAAATAA	0.333000													13	50					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42608869	42608869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42608869G>A	ENST00000359486.3	-	1	2579	c.2443C>T	c.(2443-2445)Ccc>Tcc	p.P815S	TCF20_ENST00000335626.4_Missense_Mutation_p.P815S	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	815					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CCCCAGTGGGGATTTTCTAAT	0.443000													30	70					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34038291	34038291	+	Splice_Site	SNP	G	G	A	rs139241831		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34038291G>A	ENST00000373381.4	-	50	7753	c.7576_splice	c.e50-1	p.A2526_splice		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2528	Sushi 14.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACAGGAAAGAGCTAGCAAAAG	0.448000													15	63					0	0	1	0	0
FAM111A	63901	broad.mit.edu	37	11	58920793	58920793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58920793C>T	ENST00000528737.1	+	5	4470	c.1652C>T	c.(1651-1653)tCa>tTa	p.S551L	FAM111A_ENST00000531147.1_Missense_Mutation_p.S551L|FAM111A_ENST00000361723.3_Missense_Mutation_p.S551L|FAM111A_ENST00000420244.1_Missense_Mutation_p.S551L|FAM111A_ENST00000533703.1_Missense_Mutation_p.S551L			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	551					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				TCAAAAGGTTCATTGGTGGCC	0.428000													59	131					0	0	1	0	0
TMEM65	157378	broad.mit.edu	37	8	125332403	125332403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125332403G>A	ENST00000297632.6	-	6	1079	c.545C>T	c.(544-546)tCc>tTc	p.S182F		NM_194291.2	NP_919267.2	Q6PI78	TMM65_HUMAN	transmembrane protein 65	182						integral to membrane				cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	6	Lung NSC(37;1.18e-11)|Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GCCTAACCTGGAAGCCAATGC	0.368000													47	65					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36784456	36784456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36784456G>A	ENST00000361475.2	-	3	399	c.226C>T	c.(226-228)Cgt>Tgt	p.R76C	TGM2_ENST00000536701.1_Intron|TGM2_ENST00000536724.1_Missense_Mutation_p.R16C	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	76			R -> H (in dbSNP:rs41274720).		apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	AGTGGAAAACGGGCCTTGGTC	0.657000													5	21					0	0	1	0	0
CXCR3	2833	broad.mit.edu	37	X	70836294	70836294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70836294C>T	ENST00000373691.4	-	2	1332	c.1169G>A	c.(1168-1170)gGg>gAg	p.G390E	CXCR3_ENST00000373693.3_Missense_Mutation_p.G343E	NM_001142797.1	NP_001136269.1	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3	343					cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|central_nervous_system(2)|large_intestine(2)|lung(3)|ovary(2)	10	Renal(35;0.156)					CCTCTGGAGCCCTCTCTGGTT	0.637000													5	13					0	0	1	0	0
GSDMB	55876	broad.mit.edu	37	17	38062518	38062518	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38062518G>A	ENST00000394175.2	-	5	891	c.668C>T	c.(667-669)tCt>tTt	p.S223F	GSDMB_ENST00000309481.7_Missense_Mutation_p.S232F|GSDMB_ENST00000520542.1_Missense_Mutation_p.S236F|GSDMB_ENST00000418519.1_Missense_Mutation_p.S245F|GSDMB_ENST00000394179.1_Missense_Mutation_p.S240F|GSDMB_ENST00000360317.3_Missense_Mutation_p.S245F	NM_018530.2	NP_061000.2	Q8TAX9	GSDMB_HUMAN	gasdermin B	240						cytoplasm				breast(2)|endometrium(3)|large_intestine(6)|lung(6)|pancreas(1)|prostate(1)|stomach(2)	21						CGAACCCAAAGACTTTCCTGT	0.473000													27	38					0	0	1	0	0
VASH2	79805	broad.mit.edu	37	1	213147345	213147345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:213147345G>A	ENST00000366968.4	+	8	1083	c.733G>A	c.(733-735)Gga>Aga	p.G245R	VASH2_ENST00000366967.2_Missense_Mutation_p.G206R|VASH2_ENST00000366966.2_Missense_Mutation_p.G245R|VASH2_ENST00000366965.2_Missense_Mutation_p.G266R|VASH2_ENST00000517399.1_Missense_Mutation_p.G310R|VASH2_ENST00000271776.4_3'UTR	NM_001136474.1	NP_001129946.1	Q86V25	VASH2_HUMAN	vasohibin 2	310					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		GAGAAGCCGGGGAAAATCCCT	0.572000													13	60					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288840	107288840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107288840G>A	ENST00000277216.3	-	1	650	c.651C>T	c.(649-651)tcC>tcT	p.S217S		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TGAACATATAGGAGAAAAAAA	0.408000													10	112					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71602144	71602144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71602144G>A	ENST00000355962.4	-	12	1401	c.1268C>T	c.(1267-1269)cCc>cTc	p.P423L	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	423					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CATCACCTCGGGGACTGTGAT	0.522000													9	48					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36872942	36872942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36872942G>A	ENST00000301807.6	-	21	8247	c.6350C>T	c.(6349-6351)tCc>tTc	p.S2117F	TRANK1_ENST00000429976.2_Missense_Mutation_p.S2667F|TRANK1_ENST00000428977.2_Missense_Mutation_p.S2117F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2667					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TTGCTTTTGGGAAAGAATGGT	0.542000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179501491	179501491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179501491C>T	ENST00000589042.1	-	225	41187	c.40963G>A	c.(40963-40965)Gaa>Aaa	p.E13655K	TTN_ENST00000342992.6_Missense_Mutation_p.E11087K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E12014K|TTN_ENST00000342175.6_Missense_Mutation_p.E4782K|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000418062.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E4715K|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E4590K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12014	Ig-like 92.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E4590K(1)|p.E4782K(1)|p.E11087K(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTCCTTTCGGCTTCTATT	0.433000													17	54					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115590997	115590997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:115590997C>T	ENST00000265440.7	-	6	626	c.446G>A	c.(445-447)aGa>aAa	p.R149K	TFEC_ENST00000457268.1_Missense_Mutation_p.R82K|TFEC_ENST00000484212.1_Missense_Mutation_p.R239K|TFEC_ENST00000320239.7_Missense_Mutation_p.R120K|TFEC_ENST00000393485.1_Missense_Mutation_p.R120K	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	149	Helix-loop-helix motif.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			CCTTCTTCTTCTTTCAACTAT	0.284000													14	40					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209788748	209788748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209788748C>T	ENST00000391911.1	-	22	3776	c.3387G>A	c.(3385-3387)atG>atA	p.M1129I	LAMB3_ENST00000356082.4_Missense_Mutation_p.M1129I|LAMB3_ENST00000367030.3_Missense_Mutation_p.M1129I	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1129	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GCTCCAACTCCATGTCTGAGG	0.587000													12	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179436900	179436900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179436900C>T	ENST00000589042.1	-	326	74183	c.73959G>A	c.(73957-73959)gtG>gtA	p.V24653V	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Silent_p.V22085V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Silent_p.V23012V|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Silent_p.V15780V|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.V15713V|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V15588V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23012	Fibronectin type-III 79.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGCATCTCCACAATGTAGC	0.458000													14	21					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55421210	55421210	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55421210C>T	ENST00000242994.3	+	2	1365	c.987C>T	c.(985-987)ttC>ttT	p.F329F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	329					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						ATACAGTCTTCACTGAGTGAG	0.428000													161	300					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65272664	65272664	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65272664C>T	ENST00000534336.1	+	0	7432					NR_002819.2																						TCAGGTACCCCTCACTAAAGG	0.498000													18	36					0	0	1	0	0
RFPL1	5988	broad.mit.edu	37	22	29837927	29837927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29837927C>T	ENST00000354373.2	+	2	979	c.770C>T	c.(769-771)tCc>tTc	p.S257F	RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	257	B30.2/SPRY.						zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						CAGAACGTTTCCTTTTTTGAT	0.507000													35	97					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6511792	6511792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6511792G>A	ENST00000377828.1	+	9	2213	c.2045G>A	c.(2044-2046)gGg>gAg	p.G682E	ESPN_ENST00000461727.1_Missense_Mutation_p.G116E|ESPN_ENST00000416731.1_Missense_Mutation_p.G116E|ESPN_ENST00000475228.1_3'UTR	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	682	Pro-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		TCAGGCATCGGGCAGCCGGCC	0.682000													7	18					0	0	1	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87329812	87329812	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87329812C>T	ENST00000338056.3	+	4	776	c.365C>T	c.(364-366)tCa>tTa	p.S122L	RUNDC3B_ENST00000394654.3_Missense_Mutation_p.S105L|RUNDC3B_ENST00000493037.1_Missense_Mutation_p.S105L|ABCB1_ENST00000265724.3_Intron	NM_001134405.1|NM_138290.2	NP_001127877.1|NP_612147.1	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B	122	RUN.									breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(2)	26	Esophageal squamous(14;0.00164)					CGGAAAGTTTCACAGAATTGT	0.383000													26	55					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56372893	56372893	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56372893C>T	ENST00000301295.6	+	4	2420	c.1998C>T	c.(1996-1998)agC>agT	p.S666S	NLRP4_ENST00000587891.1_Silent_p.S591S|NLRP4_ENST00000346986.5_Silent_p.S666S	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	666							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGCATCCCAGCTGTCGCCTTC	0.557000													24	58					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32624481	32624481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32624481C>T	ENST00000286827.3	-	6	1459	c.988G>A	c.(988-990)Gag>Aag	p.E330K	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Missense_Mutation_p.E330K	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	330					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TCTGCAAACTCACTGCCCTCG	0.572000													74	233					0	0	1	0	0
TCN1	6947	broad.mit.edu	37	11	59630139	59630139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59630139G>A	ENST00000257264.3	-	3	420	c.316C>T	c.(316-318)Cgt>Tgt	p.R106C	TCN1_ENST00000532419.1_5'UTR	NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	106					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCAGCGTTACGACATACTCCC	0.358000													33	106					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227895207	227895207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227895207G>A	ENST00000396625.3	-	41	4132	c.3925C>T	c.(3925-3927)Cca>Tca	p.P1309S	COL4A4_ENST00000329662.7_Missense_Mutation_p.P1309S	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1309	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTGTATCCTGGAGGGCCTGGT	0.537000													33	109					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151156198	151156198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151156198G>A	ENST00000282466.3	-	6	6150	c.6151C>T	c.(6151-6153)Ctc>Ttc	p.L2051F	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2051	Ig-like C2-type 7.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTCCCATGGAGCACTTGCTTT	0.438000													41	125					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101413856	101413856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101413856G>A	ENST00000392979.3	+	8	1035	c.674G>A	c.(673-675)aGa>aAa	p.R225K	ANO4_ENST00000392977.3_Missense_Mutation_p.R260K|ANO4_ENST00000538618.1_3'UTR|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	260						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						AATGCCACAAGAAGTAGAATC	0.308000										HNSCC(74;0.22)			27	55					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121980436	121980436	+	Missense_Mutation	SNP	G	G	A	rs104893689		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121980436G>A	ENST00000498619.1	+	4	992	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	CASR_ENST00000296154.5_Missense_Mutation_p.R185Q|CASR_ENST00000490131.1_Missense_Mutation_p.R185Q	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	185			R -> Q (in FHH).		anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TCTTTCCTCCGAACCATCCCC	0.502000													58	156					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162696315	162696315	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:162696315G>A	ENST00000375514.5	+	5	614	c.327G>A	c.(325-327)agG>agA	p.R109R	SLC4A10_ENST00000421911.1_Silent_p.R98R|SLC4A10_ENST00000446997.1_Silent_p.R98R|SLC4A10_ENST00000272716.5_Silent_p.R98R|SLC4A10_ENST00000535165.1_Silent_p.R98R|SLC4A10_ENST00000493021.1_3'UTR|SLC4A10_ENST00000415876.2_Silent_p.R98R	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	98					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CATCACAGAGGGTACAGTTTA	0.453000													15	43					0	0	1	0	0
DDX25	29118	broad.mit.edu	37	11	125787074	125787074	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:125787074G>A	ENST00000263576.6	+	9	1121	c.966G>A	c.(964-966)agG>agA	p.R322R	RP11-680F20.9_ENST00000533033.2_RNA|DDX25_ENST00000525943.1_3'UTR	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	322	Helicase C-terminal.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		GTGAGCACAGGAAAGACAAAT	0.468000													8	16					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72267089	72267089	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:72267089C>T	ENST00000340726.3	-	3	691	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	EYA1_ENST00000388742.4_Missense_Mutation_p.E18K|EYA1_ENST00000388741.2_Intron|EYA1_ENST00000303824.7_Missense_Mutation_p.E18K|EYA1_ENST00000419131.1_Missense_Mutation_p.E18K|EYA1_ENST00000388743.2_Missense_Mutation_p.E18K|EYA1_ENST00000388740.3_Intron	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	18					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTGGGGGATTCACTACTACCA	0.453000													50	132					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111077171	111077171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111077171G>A	ENST00000360467.5	+	5	577	c.271G>A	c.(271-273)Ggt>Agt	p.G91S		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	91					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGGAGACAAGGGTGAAAGGGG	0.637000													25	64					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43610472	43610472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43610472C>T	ENST00000372806.3	+	4	343	c.248C>T	c.(247-249)cCt>cTt	p.P83L	STK4_ENST00000499879.2_Missense_Mutation_p.P83L|STK4_ENST00000372801.1_Missense_Mutation_p.P83L|STK4_ENST00000396731.4_Missense_Mutation_p.P83L	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	83	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				CTCTCTAGCCCTCATGTAGTC	0.343000													16	53					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44934018	44934018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44934018C>T	ENST00000291187.4	-	6	1242	c.920G>A	c.(919-921)aGa>aAa	p.R307K	ZNF229_ENST00000588931.1_Missense_Mutation_p.R313K|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				TGTGGGAACTCTTTGATGTCT	0.507000													7	38					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34022007	34022007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34022007C>T	ENST00000374372.1	-	4	1709	c.1206G>A	c.(1204-1206)cgG>cgA	p.R402R	GDF5OS_ENST00000374375.1_Silent_p.F17F|GDF5_ENST00000374369.3_Silent_p.R402R			P43026	GDF5_HUMAN	growth differentiation factor 5	402					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GCAGTGCCTTCCGACTGCAGC	0.607000													39	124					0	0	1	0	0
SPTLC2	9517	broad.mit.edu	37	14	78021720	78021720	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:78021720G>A	ENST00000216484.2	-	8	1292	c.1099C>T	c.(1099-1101)Ccc>Tcc	p.P367S		NM_004863.3	NP_004854.1	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base subunit 2	367						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(5)	19			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACATCCTCGGGATCCAGGCCA	0.512000													77	139					0	0	1	0	0
ARID3B	10620	broad.mit.edu	37	15	74883703	74883703	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74883703C>T	ENST00000346246.5	+	6	1324	c.1093C>T	c.(1093-1095)Ctt>Ttt	p.L365F		NM_006465.2	NP_006456.1	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B (BRIGHT-like)	365	Interaction with RB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(2)	14						CTTTCCCATCCTTGGGCTTGG	0.622000													31	171					0	0	1	0	0
ABHD14B	84836	broad.mit.edu	37	3	52003883	52003883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52003883C>T	ENST00000461108.1	-	3	613	c.529G>A	c.(529-531)Ggg>Agg	p.G177R	ABHD14B_ENST00000361143.5_Intron|ABHD14B_ENST00000395008.2_Intron|ABHD14B_ENST00000525795.1_Intron|ABHD14B_ENST00000483233.1_Intron|RP11-155D18.12_ENST00000488257.1_RNA|ABHD14B_ENST00000487005.1_Intron|ABHD14B_ENST00000315877.10_Intron			Q96IU4	ABHEB_HUMAN	abhydrolase domain containing 14B	0						cytoplasm|nucleus	hydrolase activity			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000548)|KIRC - Kidney renal clear cell carcinoma(197;0.00072)		TTATCCAGCCCCCAGATGAGG	0.562000													8	38					0	0	1	0	0
TEC	7006	broad.mit.edu	37	4	48169959	48169959	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48169959G>A	ENST00000381501.3	-	7	664	c.507C>T	c.(505-507)ccC>ccT	p.P169P		NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	169					intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						GAATTGGTGGGGGAGGCCTTC	0.383000													11	101					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22838343	22838343	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22838343C>T	ENST00000404138.1	+	12	2688	c.2177C>T	c.(2176-2178)tCa>tTa	p.S726L	ZBTB40_ENST00000374651.4_Missense_Mutation_p.S614L|ZBTB40_ENST00000375647.4_Missense_Mutation_p.S726L	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	726					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		AAAGAGGCTTCAGCCTCCCCA	0.527000													13	43					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137777102	137777102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137777102G>A	ENST00000350339.2	+	4	219	c.205G>A	c.(205-207)Gac>Aac	p.D69N	FCN2_ENST00000291744.6_Missense_Mutation_p.D107N	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	107	Collagen-like.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		TACCTGCAAGGACCTGCTAGA	0.667000													12	35					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369238	22369238	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22369238T>G	ENST00000332663.2	+	1	761	c.663T>G	c.(661-663)ctT>ctG	p.L221L	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATGCCTTCCTTCTGGCCTTGT	0.478000													52	125					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67155970	67155970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:67155970C>T	ENST00000371037.4	+	17	1618	c.1541C>T	c.(1540-1542)tCc>tTc	p.S514F	SGIP1_ENST00000371035.3_Missense_Mutation_p.S304F|SGIP1_ENST00000371036.3_Missense_Mutation_p.S314F|SGIP1_ENST00000371039.1_Missense_Mutation_p.S315F|SGIP1_ENST00000237247.6_Missense_Mutation_p.S545F	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	514					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						TCAACCAATTCCTTGAGCGCA	0.468000													68	175					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	626031	626031	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:626031C>T	ENST00000470411.2	+	3	926	c.882C>T	c.(880-882)tcC>tcT	p.S294S	PIGQ_ENST00000409527.2_Intron|PIGQ_ENST00000321878.5_Intron|PIGQ_ENST00000026218.5_Intron			Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	0	Leu-rich.				C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				CTTCTCCATCCCCCTCTGCAC	0.711000													4	2					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104031893	104031893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104031893G>A	ENST00000388887.2	+	8	1013	c.809G>A	c.(808-810)gGg>gAg	p.G270E		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	270	EGF-like 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GGCTACCGTGGGGATGGCCAA	0.502000													28	83					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169111329	169111329	+	Missense_Mutation	SNP	G	G	A	rs139449745		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169111329G>A	ENST00000256935.8	+	8	816	c.736G>A	c.(736-738)Gac>Aac	p.D246N		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	246					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCTCTCTACGACCCCAACAA	0.498000													12	151					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71218869	71218869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71218869C>T	ENST00000393567.2	-	3	310	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	HYDIN_ENST00000538248.1_Missense_Mutation_p.E81K|HYDIN_ENST00000541601.1_Missense_Mutation_p.E71K|HYDIN_ENST00000288168.10_Missense_Mutation_p.E71K|HYDIN_ENST00000321489.5_Missense_Mutation_p.E54K|HYDIN_ENST00000448691.1_Missense_Mutation_p.E54K|HYDIN_ENST00000448089.2_Missense_Mutation_p.E54K|HYDIN_ENST00000393550.2_Missense_Mutation_p.E54K	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	54								p.E54K(2)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGGGACATTTCCTTCAGGAAC	0.408000													20	70					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90254384	90254384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90254384C>T	ENST00000469640.2	+	5	914	c.539C>T	c.(538-540)aCt>aTt	p.T180I	DAPK1_ENST00000358077.5_Missense_Mutation_p.T180I|DAPK1_ENST00000408954.3_Missense_Mutation_p.T180I|DAPK1_ENST00000472284.1_Missense_Mutation_p.T180I|DAPK1_ENST00000491893.1_Missense_Mutation_p.T180I			P53355	DAPK1_HUMAN	death-associated protein kinase 1	180	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						ATATTTGGGACTCCAGAGTTT	0.398000									Chronic Lymphocytic Leukemia, Familial Clustering of				26	101					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169690823	169690823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169690823G>A	ENST00000444448.2	+	9	968	c.492G>A	c.(490-492)aaG>aaA	p.K164K	NOSTRIN_ENST00000458381.2_Silent_p.K164K|NOSTRIN_ENST00000421711.2_Silent_p.K136K|NOSTRIN_ENST00000397209.2_Silent_p.K136K|NOSTRIN_ENST00000317647.7_Silent_p.K164K|NOSTRIN_ENST00000397206.2_Silent_p.K86K|NOSTRIN_ENST00000445023.2_Silent_p.K86K			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	164					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						TGACTGAGAAGGAGAAGCGGA	0.463000													14	56					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897751	175897751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175897751G>A	ENST00000359240.3	+	5	1745	c.1075G>A	c.(1075-1077)Ggc>Agc	p.G359S	ADAM29_ENST00000445694.1_Missense_Mutation_p.G359S|ADAM29_ENST00000404450.4_Missense_Mutation_p.G359S|ADAM29_ENST00000514159.1_Missense_Mutation_p.G359S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	359	Peptidase M12B.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AATGCATGAAGGCAACCCACC	0.373000													47	111					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152329580	152329580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152329580C>T	ENST00000388718.5	-	3	754	c.682G>A	c.(682-684)Gga>Aga	p.G228R	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	228	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTTTGATCCAGATCCAGAT	0.438000													80	234					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9801402	9801402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9801402C>T	ENST00000256460.3	-	9	955	c.778G>A	c.(778-780)Gac>Aac	p.D260N	OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	260	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TTCTCTGGGTCCTTCTCCATC	0.517000													78	159					0	0	1	0	0
EPN3	55040	broad.mit.edu	37	17	48613885	48613885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48613885G>A	ENST00000537145.1	+	2	352	c.215G>A	c.(214-216)gGg>gAg	p.G72E	EPN3_ENST00000268933.3_5'UTR|EPN3_ENST00000541226.1_5'UTR			Q9H201	EPN3_HUMAN	epsin 3	208	ENTH.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CCTCCGGCGGGGGCGAGGGCC	0.622000													21	61					0	0	1	0	0
MYO1C	4641	broad.mit.edu	37	17	1371776	1371776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:1371776G>A	ENST00000359786.5	-	26	2949	c.2625C>T	c.(2623-2625)gcC>gcT	p.A875A	MYO1C_ENST00000361007.2_Silent_p.A840A|MYO1C_ENST00000438665.2_Silent_p.A856A|MYO1C_ENST00000545534.2_Silent_p.A851A|MYO1C_ENST00000575158.1_Silent_p.A840A	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	875					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CACTAGCCACGGCCTTCTGCT	0.587000													19	26					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75499524	75499524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75499524C>T	ENST00000360639.2	+	2	1455	c.1135C>T	c.(1135-1137)Cct>Tct	p.P379S	C15orf39_ENST00000567617.1_Missense_Mutation_p.P379S|C15orf39_ENST00000394987.4_Missense_Mutation_p.P379S			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	379										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						ACTGAGTTTTCCTTATGCCCG	0.627000													150	184					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81744996	81744996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81744996G>A	ENST00000555447.1	-	6	1071	c.659C>T	c.(658-660)cCt>cTt	p.P220L	STON2_ENST00000556280.1_5'UTR|STON2_ENST00000267540.2_Missense_Mutation_p.P220L	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	220					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TGGAGGGGCAGGGTGCCCATT	0.532000													27	49					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27333047	27333047	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:27333047G>A	ENST00000429845.2	-	18	1766	c.1404C>T	c.(1402-1404)ttC>ttT	p.F468F	NEK10_ENST00000341435.5_Silent_p.F468F			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	468							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CTATGTCAATGAAGATCTCAA	0.348000													11	21					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14905687	14905687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14905687G>A	ENST00000285046.5	+	2	2688	c.2578G>A	c.(2578-2580)Gag>Aag	p.E860K	FGD5_ENST00000543601.1_Missense_Mutation_p.E619K	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	860					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						AGCCCCCAAAGAGGACCTTAC	0.547000													21	57					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22130333	22130333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:22130333C>T	ENST00000389398.5	+	12	1197	c.1101C>T	c.(1099-1101)acC>acT	p.T367T	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	367						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		AGGCGCTCACCTGCACCATGG	0.617000													5	10					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152057846	152057846	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152057846G>A	ENST00000368806.1	-	3	2376	c.2312C>T	c.(2311-2313)tCt>tTt	p.S771F		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	771							calcium ion binding	p.S771Y(1)		breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GGGGACTGAAGAATTGTGCTC	0.493000													26	124					0	0	1	0	0
MIR518F	574472	broad.mit.edu	37	19	54203316	54203316	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54203316G>A	ENST00000384973.1	+	0	48					NR_030194.1																						TTGTCTAAAAGAAAAGAAAGC	0.388000													26	113					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70257751	70257751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70257751G>A	ENST00000310961.5	+	5	648	c.230G>A	c.(229-231)cGa>cAa	p.R77Q	LRRC7_ENST00000035383.5_Missense_Mutation_p.R72Q|LRRC7_ENST00000370958.1_Missense_Mutation_p.R110Q|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	72						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CAAGCTCTACGAAAACTAAGT	0.294000													26	78					0	0	1	0	0
SYT13	57586	broad.mit.edu	37	11	45277287	45277287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:45277287G>A	ENST00000020926.3	-	2	450	c.339C>T	c.(337-339)agC>agT	p.S113S		NM_001247987.1|NM_020826.2	NP_001234916.1|NP_065877.1	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	113						transport vesicle				breast(1)|large_intestine(3)|lung(16)|ovary(1)|skin(2)	23						GGGGTTGGGGGCTGGCAGGTG	0.587000													9	29					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531517	92531517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92531517G>A	ENST00000298047.6	+	9	5355	c.5338G>A	c.(5338-5340)Gag>Aag	p.E1780K	FAT3_ENST00000525166.1_Missense_Mutation_p.E1630K|FAT3_ENST00000409404.2_Missense_Mutation_p.E1780K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1780	Cadherin 16.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGCCTAAGTGAGGCTGCCCC	0.458000										TCGA Ovarian(4;0.039)			14	21					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110448612	110448612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110448612C>T	ENST00000378402.5	+	30	3655	c.3551C>T	c.(3550-3552)tCa>tTa	p.S1184L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1184	IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity	p.S1186L(1)		NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AATGAAAATTCAAAGGTATTA	0.348000										HNSCC(38;0.096)			21	51					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94884136	94884136	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94884136G>A	ENST00000331706.4	+	0	1017				MCTP2_ENST00000543482.1_Missense_Mutation_p.G318S|MCTP2_ENST00000451018.3_Missense_Mutation_p.G318S|MCTP2_ENST00000357742.4_Missense_Mutation_p.G318S			Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GGTAAAACAGGGTGATTTCAA	0.373000													14	71					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43285837	43285837	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:43285837C>T	ENST00000374518.4	+	5	577	c.514C>T	c.(514-516)Caa>Taa	p.Q172*		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	172					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAACATCTGTCAAGTACATGG	0.378000													40	136					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858068	9858068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9858068G>A	ENST00000396573.2	-	14	3642	c.3333C>T	c.(3331-3333)agC>agT	p.S1111S	GRIN2A_ENST00000535259.1_Silent_p.S954S|GRIN2A_ENST00000404927.2_Silent_p.S1111S|GRIN2A_ENST00000562109.1_Silent_p.S1111S|GRIN2A_ENST00000330684.3_Silent_p.S1111S|GRIN2A_ENST00000396575.2_Silent_p.S1111S	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1111					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.S1111R(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTCTAGGGGAGCTTGATTTGG	0.483000													47	103					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56650809	56650809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56650809G>A	ENST00000267116.7	-	4	372	c.251C>T	c.(250-252)tCc>tTc	p.S84F		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	84							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						CTCGTTTCGGGAGGCAGCAGC	0.498000													4	34					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167240254	167240254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167240254C>T	ENST00000308378.3	-	12	1872	c.1567G>A	c.(1567-1569)Gaa>Aaa	p.E523K	WDR49_ENST00000453925.2_Intron|WDR49_ENST00000479765.1_Intron|WDR49_ENST00000476376.1_Missense_Mutation_p.E348K	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	523										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						AGGCAGTTTTCAATATGCCAG	0.313000													17	57					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539234	55539234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55539234C>T	ENST00000220676.1	+	4	2940	c.2792C>T	c.(2791-2793)cCt>cTt	p.P931L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	931					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACTTTAAAGCCTATAAAATCA	0.323000													15	45					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128322868	128322868	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128322868C>T	ENST00000389524.4	+	4	246	c.193C>T	c.(193-195)Cag>Tag	p.Q65*	MYO7B_ENST00000428314.1_Nonsense_Mutation_p.Q65*|MYO7B_ENST00000409816.2_Nonsense_Mutation_p.Q65*			Q6PIF6	MYO7B_HUMAN	myosin VIIB	65						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CAACTCAGTCCAGGGTGTGGA	0.592000													9	44					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43683254	43683254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43683254C>T	ENST00000599812.1	-	3	581	c.486G>A	c.(484-486)atG>atA	p.M162I	PSG5_ENST00000407356.1_Intron|PSG5_ENST00000404580.1_Intron|PSG5_ENST00000342951.6_Intron|PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407568.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	162	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				TCACAGCCTCCATGGCCTCCC	0.522000													79	264					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35974178	35974178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:35974178C>T	ENST00000297866.5	+	8	1341	c.1275C>T	c.(1273-1275)ttC>ttT	p.F425F		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	425										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AACCTTGTTTCATGGGTGAAC	0.363000													36	59					0	0	1	0	0
TCEB3	6924	broad.mit.edu	37	1	24082811	24082811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24082811C>T	ENST00000418390.2	+	9	2369	c.2098C>T	c.(2098-2100)Cgt>Tgt	p.R700C		NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	700	Activation domain (By similarity).				positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CAAGCCACCTCGTGACGTCCG	0.498000													3	8					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124459232	124459232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124459232C>T	ENST00000329446.4	-	1	106	c.75G>A	c.(73-75)agG>agA	p.R25R		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	25										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				TTTCATTCTTCCTTTCTTGCA	0.448000													24	65					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480398	140480398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140480398G>A	ENST00000231130.2	+	1	165	c.165G>A	c.(163-165)agG>agA	p.R55R	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		55	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGGACTAAGGGTAGAGGAAC	0.512000													29	86					0	0	1	0	0
ESYT3	83850	broad.mit.edu	37	3	138191536	138191536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138191536C>T	ENST00000389567.4	+	18	2258	c.2072C>T	c.(2071-2073)aCt>aTt	p.T691I		NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	691						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						ATCTTCCTGACTGTCCCAGGT	0.602000													38	105					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367233	234367233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:234367233G>A	ENST00000366618.3	+	3	499	c.354G>A	c.(352-354)ggG>ggA	p.G118G	SLC35F3_ENST00000366617.3_Silent_p.G49G	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	49					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			AGGCCGGCGGGAGAGCGAGTC	0.746000													23	37					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177608588	177608588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:177608588G>A	ENST00000280193.2	-	6	1313	c.898C>T	c.(898-900)Cgg>Tgg	p.R300W	RP11-313E19.2_ENST00000504017.1_RNA|RP11-313E19.2_ENST00000509194.1_RNA	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	300	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CTGGCAGGCCGAAGCCCCGCT	0.512000													11	122					0	0	1	0	0
HBD	3045	broad.mit.edu	37	11	5254013	5254013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5254013G>A	ENST00000292901.3	-	3	380	c.331C>T	c.(331-333)Cct>Tct	p.P111S				P02042	HBD_HUMAN	hemoglobin, delta	0					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGCCTCAGGAACCTTCTTA	0.388000													4	27					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532340	84532340	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84532340G>A	ENST00000527857.1	+	0	2362					NR_026851.1																						GGAATTATCAGGGATACAGCC	0.468000													8	46					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17483289	17483289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17483289G>A	ENST00000302539.4	-	5	788	c.663C>T	c.(661-663)ttC>ttT	p.F221F	ABCC8_ENST00000389817.3_Silent_p.F221F	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	221					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GCAGATTCACGAAGGGCTGCA	0.582000													34	93					0	0	1	0	0
UGT1A5	54579	broad.mit.edu	37	2	234621899	234621899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234621899G>A	ENST00000373414.3	+	1	262	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000373445.1_Intron	NM_019078.1	NP_061951.1														cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GACCCAGGACGAATTTGATCG	0.428000													53	113					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4703806	4703806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4703806C>T	ENST00000354582.6	+	15	1642	c.1292C>T	c.(1291-1293)gCc>gTc	p.A431V	ITPR1_ENST00000456211.2_Missense_Mutation_p.A416V|ITPR1_ENST00000443694.2_Missense_Mutation_p.A416V|ITPR1_ENST00000423119.2_Missense_Mutation_p.A431V|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.A431V|ITPR1_ENST00000302640.8_Missense_Mutation_p.A416V			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	431	MIR 5.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GAAGCATTTGCCATAGTTCCG	0.493000													30	70					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106066395	106066395	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106066395G>A	ENST00000577108.1	-	0	136				IGHE_ENST00000576077.1_RNA																							GAGGGAGGCAGGAGTACGTCA	0.587000													21	113					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46267841	46267841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:46267841C>T	ENST00000372004.3	+	14	2818	c.2602C>T	c.(2602-2604)Cct>Tct	p.P868S	NCOA3_ENST00000371997.3_Missense_Mutation_p.P878S|NCOA3_ENST00000371998.3_Missense_Mutation_p.P868S|NCOA3_ENST00000341724.6_Intron	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	868					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TGGCTCAAGTCCTCCAGTAAA	0.438000													35	84					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115421590	115421590	+	Silent	SNP	C	C	T	rs151231750	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:115421590C>T	ENST00000337530.6	+	4	1688	c.1392C>T	c.(1390-1392)acC>acT	p.T464T	KIAA1958_ENST00000536272.1_Silent_p.T492T	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	464										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						TTTATGTCACCGTCAAGAAGA	0.542000													33	51					0	0	1	0	0
APOBEC1	339	broad.mit.edu	37	12	7805044	7805044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7805044C>T	ENST00000229304.4	-	3	452	c.432G>A	c.(430-432)atG>atA	p.M144I		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	144					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						CTGATGCTCTCATAATCTGAA	0.418000													12	54					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833244	168833244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168833244C>T	ENST00000464456.1	-	7	3052	c.1852G>A	c.(1852-1854)Gaa>Aaa	p.E618K	MECOM_ENST00000433243.2_Missense_Mutation_p.E619K|MECOM_ENST00000472280.1_Missense_Mutation_p.E619K|MECOM_ENST00000392736.3_Missense_Mutation_p.E618K|MECOM_ENST00000494292.1_Missense_Mutation_p.E806K|MECOM_ENST00000468789.1_Missense_Mutation_p.E618K|MECOM_ENST00000264674.3_Missense_Mutation_p.E683K|MECOM_ENST00000460814.1_Missense_Mutation_p.E618K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	27							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GGTCTTGATTCGACGTTGCTT	0.473000													6	55					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157659643	157659643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157659643G>A	ENST00000368184.3	-	10	2046	c.1755C>T	c.(1753-1755)ctC>ctT	p.L585L	FCRL3_ENST00000368186.5_Silent_p.L585L|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	585						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CAGCAAGGACGAGGATGCTGA	0.567000													30	49					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120373013	120373013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:120373013C>T	ENST00000331113.4	+	2	2137	c.1172C>T	c.(1171-1173)tCg>tTg	p.S391L		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	391					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TCTATCTGTTCGCTGAGTGGG	0.418000													25	74					0	0	1	0	0
ASPG	374569	broad.mit.edu	37	14	104575594	104575594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104575594G>A	ENST00000551177.1	+	13	1554	c.1462G>A	c.(1462-1464)Gaa>Aaa	p.E488K	ASPG_ENST00000546892.2_Missense_Mutation_p.E488K|ASPG_ENST00000455920.2_Missense_Mutation_p.E488K	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	488					lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						GTTGCTGCGGGAAGCCGGGGC	0.652000													9	28					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186559240	186559240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186559240C>T	ENST00000393528.3	-	12	1636	c.899G>A	c.(898-900)gGa>gAa	p.G300E	SORBS2_ENST00000431808.1_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000355634.5_Intron|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000418609.1_Intron|SORBS2_ENST00000284776.7_Intron	NM_003603.5	NP_003594.3	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	228						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TACCGGGCGTCCAAACTCCAG	0.373000													23	152					0	0	1	0	0
PELI2	57161	broad.mit.edu	37	14	56763866	56763866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:56763866C>T	ENST00000267460.4	+	6	1531	c.1245C>T	c.(1243-1245)ttC>ttT	p.F415F		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	415					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						AATTAATTTTCCAAGGTCCAA	0.433000													4	25					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74623563	74623563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74623563G>A	ENST00000321288.5	+	17	2306	c.2306G>A	c.(2305-2307)cGg>cAg	p.R769Q	CCDC33_ENST00000398814.3_Missense_Mutation_p.R566Q|CCDC33_ENST00000268082.4_Missense_Mutation_p.R159Q|CCDC33_ENST00000558821.1_Missense_Mutation_p.R159Q			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	769							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AAGATGGAGCGGGTGCTGGAG	0.642000													10	57					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232581315	232581315	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:232581315G>A	ENST00000366630.1	-	10	3671	c.3313C>T	c.(3313-3315)Cga>Tga	p.R1105*	SIPA1L2_ENST00000262861.4_Nonsense_Mutation_p.R1105*|SIPA1L2_ENST00000308942.4_Nonsense_Mutation_p.R179*			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1105					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GAGGTGCTTCGAGGAATGGCA	0.637000													16	54					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45402903	45402903	+	Silent	SNP	G	G	A	rs144183694	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45402903G>A	ENST00000389039.6	-	8	1273	c.888C>T	c.(886-888)atC>atT	p.I296I	DUOX2_ENST00000603300.1_Silent_p.I296I			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	296	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CATACACAGCGATGTTCTGAG	0.607000													13	35					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110493734	110493734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110493734C>T	ENST00000378402.5	+	56	9504	c.9400C>T	c.(9400-9402)Cat>Tat	p.H3134Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3134	G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TAGAGGAAATCATACTACACA	0.398000										HNSCC(38;0.096)			5	15					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180048704	180048704	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180048704G>A	ENST00000261937.6	-	13	1936	c.1858C>T	c.(1858-1860)Ctg>Ttg	p.L620L	FLT4_ENST00000393347.3_Silent_p.L620L|FLT4_ENST00000502649.1_Silent_p.L620L|FLT4_ENST00000424276.2_5'UTR	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	620	Ig-like C2-type 6.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGGCGGCCAGAGGGGTGGCG	0.682000													7	32					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468962	56468962	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:56468962G>A	ENST00000288221.6	-	2	329	c.74C>T	c.(73-75)cCt>cTt	p.P25L		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	25						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GCCCAAACGAGGAGACCTTGG	0.488000													19	52					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520004	131520004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131520004C>T	ENST00000423981.1	+	2	469	c.359C>T	c.(358-360)tCc>tTc	p.S120F	AMER3_ENST00000321420.4_Missense_Mutation_p.S120F	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		TTCCCGGGCTCCCCGGGCAGC	0.642000													12	23					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94650958	94650958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94650958G>A	ENST00000260526.6	-	17	2042	c.1860C>T	c.(1858-1860)tcC>tcT	p.S620S	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	620					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ATTTCGTGGGGGATCTCAATT	0.398000													37	82					0	0	1	0	0
TNFSF18	8995	broad.mit.edu	37	1	173010692	173010692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173010692G>A	ENST00000404377.3	-	3	415	c.415C>T	c.(415-417)Ctg>Ttg	p.L139L	RP1-15D23.2_ENST00000432694.1_RNA|TNFSF18_ENST00000239468.2_Silent_p.L117L	NM_005092.3	NP_005083.2	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily, member 18	139					anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	9						TTTTTATACAGCCGCACCTCA	0.383000													23	81					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247063417	247063417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247063417G>A	ENST00000366508.1	-	10	1623	c.1487C>T	c.(1486-1488)cCt>cTt	p.P496L	AHCTF1_ENST00000326225.3_Missense_Mutation_p.P470L|AHCTF1_ENST00000391829.2_Missense_Mutation_p.P461L			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	461	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TGGATATGAAGGAGGGACTCC	0.368000													61	187					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72156856	72156856	+	Nonsense_Mutation	SNP	G	G	A	rs140352254		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72156856G>A	ENST00000537465.1	-	19	2898	c.2740C>T	c.(2740-2742)Cga>Tga	p.R914*	PMFBP1_ENST00000355636.6_Nonsense_Mutation_p.R764*|PMFBP1_ENST00000537792.1_Nonsense_Mutation_p.R75*|PMFBP1_ENST00000237353.10_Nonsense_Mutation_p.R909*			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	914										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				ACCTGCTCTCGGAGCTGGTTT	0.532000													14	33					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370490	240370490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240370490G>A	ENST00000319653.9	+	5	2608	c.2378G>A	c.(2377-2379)cGa>cAa	p.R793Q		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	793	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCTCCAAGGCGAATATCAGTC	0.577000													20	78					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688487	26688487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26688487C>T	ENST00000529632.2	+	2	406	c.210C>T	c.(208-210)ccC>ccT	p.P70P	SEZ6L_ENST00000360929.3_Silent_p.P70P|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000404234.3_Silent_p.P70P|SEZ6L_ENST00000343706.4_Silent_p.P70P|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000248933.6_Silent_p.P70P	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	70						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						TAACAGCGCCCCCCAGTTCCT	0.632000													8	42					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9364963	9364963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9364963C>T	ENST00000378501.2	+	11	984	c.969C>T	c.(967-969)ttC>ttT	p.F323F	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Silent_p.F323F|PLCB4_ENST00000278655.4_Silent_p.F323F|PLCB4_ENST00000378493.1_Silent_p.F323F|PLCB4_ENST00000334005.3_Silent_p.F323F|PLCB4_ENST00000378473.3_Silent_p.F323F	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	323	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CTCACTACTTCATCAGTTCTT	0.468000													36	94					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43420354	43420354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43420354C>T	ENST00000601833.1	-	2	1420	c.137G>A	c.(136-138)gGa>gAa	p.G46E	PSG6_ENST00000292125.2_Missense_Mutation_p.G117E|PSG6_ENST00000187910.2_Missense_Mutation_p.G117E|PSG6_ENST00000402603.4_Missense_Mutation_p.G117E					pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				GGTGTAGGATCCTGCATCCTC	0.468000													156	310					0	0	1	0	0
ZNF326	284695	broad.mit.edu	37	1	90493234	90493234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:90493234C>T	ENST00000340281.4	+	12	1866	c.1723C>T	c.(1723-1725)Cct>Tct	p.P575S	ZNF326_ENST00000455342.2_Missense_Mutation_p.P369S|ZNF326_ENST00000370447.2_Missense_Mutation_p.P486S	NM_182976.2	NP_892021.1	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326	575	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(7)|ovary(1)	25		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TGCTGACTTCCCTGTTGAGCA	0.398000													26	51					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55909079	55909079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55909079G>A	ENST00000290567.9	-	1	176	c.55C>T	c.(55-57)Ctt>Ttt	p.L19F	CES5A_ENST00000541580.1_Intron|CES5A_ENST00000518005.1_Intron|CES5A_ENST00000520435.1_Missense_Mutation_p.L19F|CES5A_ENST00000521992.1_Intron|CES5A_ENST00000319165.9_Missense_Mutation_p.L19F	NM_001143685.1	NP_001137157.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	19						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GGGGCTGCAAGGACCCAGATA	0.532000													29	115					0	0	1	0	0
AOC1	26	broad.mit.edu	37	7	150553935	150553935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150553935G>A	ENST00000493429.1	+	4	961	c.377G>A	c.(376-378)cGa>cAa	p.R126Q	AOC1_ENST00000467291.1_Missense_Mutation_p.R126Q|AOC1_ENST00000416793.2_Missense_Mutation_p.R126Q|AOC1_ENST00000360937.4_Missense_Mutation_p.R126Q					amine oxidase, copper containing 1																		TGCTACATGCGAGCACTGTCC	0.637000													36	84					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48609816	48609816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48609816C>T	ENST00000328333.8	-	89	7082	c.6975G>A	c.(6973-6975)gaG>gaA	p.E2325E	COL7A1_ENST00000454817.1_Silent_p.E2293E	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2325	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TACTTACCGGCTCACCCACCA	0.597000													36	84					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	97987291	97987291	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97987291G>A	ENST00000224337.5	-	5	377	c.236C>T	c.(235-237)tCg>tTg	p.S79L	BLNK_ENST00000371176.2_Missense_Mutation_p.S79L|BLNK_ENST00000413476.2_Missense_Mutation_p.S79L|BLNK_ENST00000427367.2_Missense_Mutation_p.S79L	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	79					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CTCTGAGTCCGAGTGCTCATC	0.592000													16	130					0	0	1	0	0
YOD1	55432	broad.mit.edu	37	1	207222587	207222587	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207222587G>A	ENST00000367084.1	-	4	897	c.693C>T	c.(691-693)ttC>ttT	p.F231F	YOD1_ENST00000391927.1_Silent_p.F231F|YOD1_ENST00000315927.4_Silent_p.F275F	NM_001276320.1	NP_001263249.1	Q5VVQ6	OTU1_HUMAN	YOD1 deubiquitinase	275	OTU.				cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(3)	11	Prostate(682;0.19)					CTGGATCAGGGAAGTTACGCT	0.413000													74	179					0	0	1	0	0
RHBDD1	84236	broad.mit.edu	37	2	227731973	227731973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227731973C>T	ENST00000392062.2	+	5	1029	c.505C>T	c.(505-507)Cct>Tct	p.P169S	RHBDD1_ENST00000341329.3_Missense_Mutation_p.P169S	NM_001167608.1	NP_001161080.1	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	169						integral to membrane	serine-type endopeptidase activity			breast(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		TTTGGGCTTTCCTGTACCGAA	0.393000													65	203					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	131009728	131009728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131009728C>T	ENST00000341179.7	+	17	1948	c.1856C>T	c.(1855-1857)tCc>tTc	p.S619F	DNM1_ENST00000393594.3_Missense_Mutation_p.S619F|DNM1_ENST00000475805.1_Missense_Mutation_p.S619F|DNM1_ENST00000372923.3_Missense_Mutation_p.S619F|DNM1_ENST00000486160.1_Missense_Mutation_p.S619F	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	619	PH.				receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						TGGAAGGCCTCCTTCCTGAGG	0.607000													6	21					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29295578	29295578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29295578G>A	ENST00000331664.5	-	1	1549	c.1550C>T	c.(1549-1551)tCa>tTa	p.S517L		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	517					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						GTCAGCAGGTGAAGATTGTGG	0.542000													56	94					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634006	70634006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70634006C>T	ENST00000381269.2	-	2	1887	c.1134G>A	c.(1132-1134)aaG>aaA	p.K378K	SLC8A3_ENST00000528359.1_Silent_p.K378K|SLC8A3_ENST00000357887.3_Silent_p.K378K|SLC8A3_ENST00000534137.1_Silent_p.K378K|SLC8A3_ENST00000356921.2_Silent_p.K378K	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	378					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TGGAGGCCTTCTTGGCTTGTT	0.517000													54	106					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113288760	113288760	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113288760G>A	ENST00000362072.3	-	3	728	c.384C>T	c.(382-384)atC>atT	p.I128I	DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000346454.3_Silent_p.I128I|DRD2_ENST00000542968.1_Silent_p.I128I|DRD2_ENST00000538967.1_Silent_p.I128I|DRD2_ENST00000355319.2_Silent_p.I128I|DRD2_ENST00000544518.1_Silent_p.I127I	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	128					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	TGTCGATGCTGATGGCACACA	0.552000													9	41					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91549184	91549184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:91549184C>T	ENST00000509176.1	+	6	2021	c.1733C>T	c.(1732-1734)tCc>tTc	p.S578F	CCSER1_ENST00000432775.2_Missense_Mutation_p.S578F|CCSER1_ENST00000333691.8_Missense_Mutation_p.S578F	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		AGGAATCTTTCCCTGAAATTA	0.408000													18	48					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4648002	4648002	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4648002G>A	ENST00000433935.1	+	11	1823	c.1766G>A	c.(1765-1767)aGg>aAg	p.R589K	ZMYND15_ENST00000573751.2_Missense_Mutation_p.R589K|ZMYND15_ENST00000269289.6_Missense_Mutation_p.R550K|ZMYND15_ENST00000592813.1_Missense_Mutation_p.R550K	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	550							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						GGGGGCCGCAGGGACCTGCAG	0.617000													29	40					0	0	1	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200813990	200813990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200813990C>T	ENST00000358823.2	+	8	1372	c.1102C>T	c.(1102-1104)Cct>Tct	p.P368S	CAMSAP2_ENST00000236925.4_Missense_Mutation_p.P379S|CAMSAP2_ENST00000413307.2_Missense_Mutation_p.P368S	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	379						cytoplasm|microtubule	protein binding										TTCTGACTTCCCTTCAAGGTA	0.279000													11	68					0	0	1	0	0
DNAJA3	9093	broad.mit.edu	37	16	4491432	4491432	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4491432C>T	ENST00000262375.6	+	4	563	c.486C>T	c.(484-486)ttC>ttT	p.F162F	DNAJA3_ENST00000355296.4_Silent_p.F162F|DNAJA3_ENST00000572139.1_3'UTR|DNAJA3_ENST00000431375.2_Intron	NM_005147.5	NP_005138.3	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	162					activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|upper_aerodigestive_tract(2)	15						CTGCAGGCTTCGATCCTGGGG	0.577000													5	51					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085504	9085504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9085504C>T	ENST00000397910.4	-	1	6514	c.6311G>A	c.(6310-6312)aGa>aAa	p.R2104K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2104	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCTGGATTTCTTTGCTTAGC	0.502000													50	152					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13125237	13125237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:13125237G>A	ENST00000319217.7	-	35	5032	c.4785C>T	c.(4783-4785)tcC>tcT	p.S1595S	MPDZ_ENST00000381015.4_Silent_p.S1595S|MPDZ_ENST00000538841.1_Silent_p.S454S|MPDZ_ENST00000447879.1_Silent_p.S1562S|MPDZ_ENST00000381022.2_Silent_p.S1595S|MPDZ_ENST00000541718.1_Silent_p.S1595S|MPDZ_ENST00000541093.1_5'UTR|MPDZ_ENST00000536827.1_Silent_p.S1562S|MPDZ_ENST00000546205.1_Silent_p.S1609S	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1595					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		CCGGTTCTGGGGAGCCAGACT	0.547000													24	47					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155160	12155160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12155160C>T	ENST00000602107.1	-	5	1196	c.1197G>A	c.(1195-1197)aaG>aaA	p.K399K	CTD-2006C1.2_ENST00000591898.1_RNA|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591838.1_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|ZNF878_ENST00000547628.1_Silent_p.K352K			C9JN71	ZN878_HUMAN	zinc finger protein 878	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TTCGAAGATCCTTGACAAAAC	0.373000													7	85					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96163702	96163702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:96163702C>T	ENST00000453304.1	-	7	1334	c.986G>A	c.(985-987)gGa>gAa	p.G329E	UNC5C_ENST00000506749.1_Missense_Mutation_p.G329E	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	329	TSP type-1 2.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GCACTCAGTTCCACAAGTAGA	0.597000													7	17					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11835445	11835445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11835445C>T	ENST00000262442.3	+	64	12288	c.12220C>T	c.(12220-12222)Cgc>Tgc	p.R4074C	DNAH9_ENST00000396001.2_Missense_Mutation_p.R386C|DNAH9_ENST00000454412.2_Missense_Mutation_p.R3998C	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4074	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGGATGGAATCGCTCATACCC	0.502000													49	63					0	0	1	0	0
MAN2A2	4122	broad.mit.edu	37	15	91449187	91449187	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91449187C>T	ENST00000360468.3	+	4	666	c.648C>T	c.(646-648)gtC>gtT	p.V216V	MAN2A2_ENST00000559717.1_Silent_p.V216V	NM_006122.2	NP_006113.2	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	216					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GGGCAGAGGTCTCCTTCTTCG	0.577000													17	40					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8130986	8130986	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8130986G>A	ENST00000600128.1	-	64	8661	c.8247C>T	c.(8245-8247)ttC>ttT	p.F2749F	FBN3_ENST00000601739.1_Silent_p.F2749F|FBN3_ENST00000270509.2_Silent_p.F2749F			Q75N90	FBN3_HUMAN	fibrillin 3	2749						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GCATGCGAAAGAAACCTTGCT	0.692000													31	101					0	0	1	0	0
RFPL4B	442247	broad.mit.edu	37	6	112671667	112671667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:112671667G>A	ENST00000441065.2	+	3	1069	c.757G>A	c.(757-759)Ggg>Agg	p.G253R		NM_001013734.2	NP_001013756.2	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	253	B30.2/SPRY.						zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	14		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CTTGGGAGAAGGGGAGAGTGG	0.448000													18	44					0	0	1	0	0
SLC1A1	6505	broad.mit.edu	37	9	4576603	4576603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:4576603G>A	ENST00000262352.3	+	10	1269	c.1033G>A	c.(1033-1035)Gaa>Aaa	p.E345K		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	345					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	CCGCTGTGCTGAAGAAAATAA	0.478000													10	92					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621171	179621171	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179621171G>A	ENST00000589042.1	-	46	11256	c.11032C>T	c.(11032-11034)Caa>Taa	p.Q3678*	TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Nonsense_Mutation_p.Q3507*|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3363	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAGGAATTGAGCCGTGTCA	0.448000													13	38					0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135078869	135078869	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:135078869G>A	ENST00000428680.2	-	10	1698	c.1419C>T	c.(1417-1419)ttC>ttT	p.F473F	CNOT4_ENST00000423368.2_Silent_p.F476F|CNOT4_ENST00000315544.5_Silent_p.F476F|CNOT4_ENST00000356162.4_Intron|CNOT4_ENST00000361528.4_Silent_p.F473F|CNOT4_ENST00000414802.1_Intron|CNOT4_ENST00000451834.1_Silent_p.F473F|CNOT4_ENST00000541284.1_Silent_p.F476F	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	476					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						GAAATTGAGGGAACCTCTGGG	0.507000													40	90					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103484	52103484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52103484C>T	ENST00000361781.2	-	7	1350	c.391G>A	c.(391-393)Gag>Aag	p.E131K	SGMS1_ENST00000361543.2_Missense_Mutation_p.E131K|SGMS1_ENST00000429490.1_Intron	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	137					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity	p.E131*(1)		endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						TTGCCCCACTCCATGGGGTAC	0.488000													38	72					0	0	1	0	0
PIGU	128869	broad.mit.edu	37	20	33162998	33162998	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33162998G>A	ENST00000374820.2	-	10	1064	c.1044C>T	c.(1042-1044)ctC>ctT	p.L348L	PIGU_ENST00000452740.2_Silent_p.L368L			Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class U	368					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						GGACAGGGAAGAGCAGGGAAC	0.493000													8	66					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370313	240370313	+	Missense_Mutation	SNP	G	G	A	rs140911005		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240370313G>A	ENST00000319653.9	+	5	2431	c.2201G>A	c.(2200-2202)cGg>cAg	p.R734Q		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	734					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAGGAAGTACGGCATCATAGG	0.557000													10	40					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22132409	22132409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:22132409G>A	ENST00000389398.5	+	13	1333	c.1237G>A	c.(1237-1239)Gtc>Atc	p.V413I	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	413						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		GTGGCTTAAGGTCAATGGTCT	0.512000													10	76					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650650	121650650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:121650650C>T	ENST00000393386.2	+	12	1961	c.1550C>T	c.(1549-1551)tCc>tTc	p.S517F	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.S517F	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	517					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AAAGATATTTCCTTGACTTCT	0.408000													31	80					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717239	13717239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13717239C>T	ENST00000279593.3	-	13	3142	c.2933G>A	c.(2932-2934)aGc>aAc	p.S978N		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	978					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTACACGTTGCTGTCCTTCAG	0.542000													14	76					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114541218	114541218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:114541218G>A	ENST00000371920.3	+	4	798	c.791G>A	c.(790-792)aGa>aAa	p.R264K	LUZP4_ENST00000451986.2_Missense_Mutation_p.R182K	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	264						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						GCCACTCAGAGAGATCTCATA	0.478000													43	35					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431664	140431664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140431664G>A	ENST00000306549.3	+	1	686	c.609G>A	c.(607-609)gaG>gaA	p.E203E		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		203	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGACCGAGAGGAGCAGCCTG	0.582000													5	32					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16001112	16001112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16001112C>T	ENST00000350896.3	-	8	1185	c.988G>A	c.(988-990)Gga>Aga	p.G330R	MSR1_ENST00000381998.4_Missense_Mutation_p.G330R|MSR1_ENST00000536385.1_Missense_Mutation_p.G104R|MSR1_ENST00000262101.5_Missense_Mutation_p.G330R|MSR1_ENST00000445506.2_Missense_Mutation_p.G348R|MSR1_ENST00000355282.2_Missense_Mutation_p.G330R	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	357	Collagen-like.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCTTTTGGTCCAGAATTTCCT	0.328000													18	56					0	0	1	0	0
MIEF2	125170	broad.mit.edu	37	17	18167217	18167217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18167217C>T	ENST00000395704.4	+	4	578	c.430C>T	c.(430-432)Ccc>Tcc	p.P144S	SMCR7_ENST00000577216.1_3'UTR|SMCR7_ENST00000395706.2_Silent_p.F179F|SMCR7_ENST00000323019.4_Silent_p.F168F			Q96C03	SMCR7_HUMAN		25						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(4)	9	all_neural(463;0.228)					GGAGCAAGTTCCCGGAACTGC	0.672000													13	12					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286946	152286946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152286946C>T	ENST00000368799.1	-	3	451	c.416G>A	c.(415-417)gGa>gAa	p.G139E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	139					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGGATCTTCCCTTATTCCC	0.353000									Ichthyosis				35	133					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71665544	71665544	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71665544G>A	ENST00000356340.3	+	16	1453	c.915_splice	c.e16-1	p.G306_splice	COL13A1_ENST00000517713.1_Splice_Site_p.G284_splice|COL13A1_ENST00000398973.3_Splice_Site_p.G306_splice|COL13A1_ENST00000398972.3_Splice_Site_p.G306_splice|COL13A1_ENST00000357811.3_Splice_Site_p.G284_splice|COL13A1_ENST00000398966.3_Splice_Site_p.G284_splice|COL13A1_ENST00000522165.1_Splice_Site_p.G287_splice|COL13A1_ENST00000398971.3_Splice_Site_p.G306_splice|COL13A1_ENST00000520133.1_Splice_Site_p.G255_splice|COL13A1_ENST00000520267.1_Splice_Site_p.G249_splice|COL13A1_ENST00000398968.3_Splice_Site_p.G287_splice|COL13A1_ENST00000398978.3_Splice_Site_p.G306_splice|COL13A1_ENST00000398974.3_Splice_Site_p.G294_splice|COL13A1_ENST00000398964.3_Splice_Site_p.G277_splice|COL13A1_ENST00000354547.3_Splice_Site_p.G284_splice|COL13A1_ENST00000398969.3_Splice_Site_p.G249_splice			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	306	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	TTTTCCCAGGGAGACCCAGGG	0.542000													9	25					0	0	1	0	0
RELA	5970	broad.mit.edu	37	11	65423223	65423223	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65423223G>A	ENST00000525693.1	-	10	1031	c.969C>T	c.(967-969)gaC>gaT	p.D323D	RELA_ENST00000308639.9_Silent_p.D320D|RELA_ENST00000406246.3_Silent_p.D323D			Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	323					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						GAGGCCGGGGGTCGGTGGGTC	0.627000													26	60					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45941801	45941801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45941801G>A	ENST00000323084.4	-	9	1596	c.1531C>T	c.(1531-1533)Ctc>Ttc	p.L511F	C21orf90_ENST00000465978.1_Intron|TSPEAR_ENST00000397916.1_Missense_Mutation_p.L443F	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	511					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						GAGCCCAGGAGTCGGATGTAG	0.632000													23	65					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798094	55798094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55798094C>T	ENST00000313555.1	+	1	200	c.200C>T	c.(199-201)tCt>tTt	p.S67F		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					AGCAACTTATCTTTCTTAGAC	0.343000													25	53					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135042402	135042402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135042402G>A	ENST00000393229.3	+	2	960	c.184G>A	c.(184-186)Gga>Aga	p.G62R	NTNG2_ENST00000372179.3_Missense_Mutation_p.G62R|NTNG2_ENST00000393228.4_Missense_Mutation_p.G62R|NTNG2_ENST00000360670.3_Missense_Mutation_p.G62R	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	62	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		CATCACATGTGGAGACCCCCC	0.587000													4	35					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45712900	45712900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45712900G>A	ENST00000291582.5	+	10	1247	c.1120G>A	c.(1120-1122)Gga>Aga	p.G374R	AIRE_ENST00000329347.4_Missense_Mutation_p.G167R|AIRE_ENST00000355347.4_Missense_Mutation_p.G167R	NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	374					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		TAGGTCGGCGGGAGAGGAGGT	0.682000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				10	65					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179621192	179621192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179621192C>T	ENST00000444136.1	+	13	2270	c.2020C>T	c.(2020-2022)Cct>Tct	p.P674S	TDRD5_ENST00000367614.1_Missense_Mutation_p.P674S|TDRD5_ENST00000294848.8_Missense_Mutation_p.P674S	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	674					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						TGAGCTCAACCCTTTAGCTTT	0.398000													9	100					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49440321	49440321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49440321C>T	ENST00000374201.3	-	10	1307	c.1005G>A	c.(1003-1005)ggG>ggA	p.G335G	FRMPD2_ENST00000407470.4_Silent_p.G304G|FRMPD2_ENST00000305531.3_Silent_p.G311G	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	335					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		AATAGGATTTCCCTTTTTTGG	0.423000													12	21					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48614120	48614120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48614120G>A	ENST00000328333.8	-	67	5796	c.5689C>T	c.(5689-5691)Cct>Tct	p.P1897S	COL7A1_ENST00000454817.1_Intron	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1897	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity	p.P1897T(1)		NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGCCAGGAGGGCCCACTGGC	0.617000													4	8					0	0	1	0	0
KIFC2	90990	broad.mit.edu	37	8	145692663	145692663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145692663G>A	ENST00000301332.2	+	4	785	c.408G>A	c.(406-408)ggG>ggA	p.G136G		NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	136					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCCCCAGGGGGAGGCAGGCCC	0.612000											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	66					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41099087	41099087	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41099087G>A	ENST00000204005.9	+	1	16	c.16_splice	c.e1+1	p.A6_splice	LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000545697.1_5'UTR	NM_003573.2	NP_003564.2	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	0					growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGACGTAAAAGGTGAGTGCCT	0.428000													18	49					0	0	1	0	0
DPY19L3	147991	broad.mit.edu	37	19	32954811	32954811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:32954811C>T	ENST00000342179.5	+	14	1697	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	DPY19L3_ENST00000392250.2_Silent_p.F494F|DPY19L3_ENST00000590651.1_3'UTR|DPY19L3_ENST00000586987.1_Silent_p.F494F	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	494						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					TGTGTGTGTTCGCATCATTCG	0.443000													84	196					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101755566	101755566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101755566G>A	ENST00000506729.1	-	8	1607	c.1436C>T	c.(1435-1437)cCa>cTa	p.P479L	SLCO6A1_ENST00000379807.3_Missense_Mutation_p.P479L|SLCO6A1_ENST00000379810.1_Intron|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.P417L|SLCO6A1_ENST00000513675.1_Intron			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	479						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AAATTGCACTGGATTACAGCG	0.323000													49	130					0	0	1	0	0
DENND6B	414918	broad.mit.edu	37	22	50757412	50757412	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50757412G>A	ENST00000413817.2	-	2	269	c.198C>T	c.(196-198)ttC>ttT	p.F66F		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		CTGTGAGCCGGAAGTCGTTCG	0.577000													10	7					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94053657	94053657	+	Missense_Mutation	SNP	G	G	A	rs72658200		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94053657G>A	ENST00000297268.6	+	41	3046	c.2575G>A	c.(2575-2577)Ggc>Agc	p.G859S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	859					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGGACCTCCTGGCACTCCAGG	0.493000										HNSCC(75;0.22)			23	71					0	0	1	0	0
TMEM194A	23306	broad.mit.edu	37	12	57453726	57453726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57453726G>A	ENST00000300128.4	-	9	1294	c.1271C>T	c.(1270-1272)tCc>tTc	p.S424F	TMEM194A_ENST00000379391.3_Missense_Mutation_p.S351F	NM_001130963.1	NP_001124435.1	O14524	T194A_HUMAN	transmembrane protein 194A	424						integral to membrane				endometrium(3)|large_intestine(3)|lung(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CTCCTCAGAGGATGCTTCCTC	0.473000													19	36					0	0	1	0	0
LRRC3	81543	broad.mit.edu	37	21	45877193	45877193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45877193C>T	ENST00000291592.4	+	2	983	c.666C>T	c.(664-666)gtC>gtT	p.V222V		NM_030891.3	NP_112153.1	Q9BY71	LRRC3_HUMAN	leucine rich repeat containing 3	222						integral to membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		TCGCCTACGTCGTGTACTATG	0.657000													32	80					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149853837	149853837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:149853837G>A	ENST00000435030.1	+	18	2451	c.2083G>A	c.(2083-2085)Gat>Aat	p.D695N	KIF5C_ENST00000397413.1_Missense_Mutation_p.D463N|KIF5C_ENST00000414838.2_Missense_Mutation_p.D600N|KIF5C_ENST00000464066.1_3'UTR			O60282	KIF5C_HUMAN	kinesin family member 5C	695					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		GCGGTTGCAGGATGCTGAAGA	0.423000													10	31					0	0	1	0	0
TRAT1	50852	broad.mit.edu	37	3	108565964	108565964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108565964G>A	ENST00000295756.6	+	4	432	c.202G>A	c.(202-204)Gat>Aat	p.D68N	TRAT1_ENST00000493604.1_3'UTR|TRAT1_ENST00000426646.1_Missense_Mutation_p.D31N	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	68					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						TAACTTAGATGATATGATTTC	0.259000													17	80					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162307203	162307203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:162307203G>A	ENST00000306100.5	-	16	2676	c.2240C>T	c.(2239-2241)tCc>tTc	p.S747F	RP11-234O6.2_ENST00000508189.1_RNA|FSTL5_ENST00000427802.2_Missense_Mutation_p.S737F|FSTL5_ENST00000379164.4_Missense_Mutation_p.S746F|FSTL5_ENST00000536695.1_Missense_Mutation_p.S746F	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	747						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCAGTAAAGGATGGTTGAAA	0.413000													25	64					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129168726	129168726	+	Silent	SNP	C	C	T	rs139138308		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129168726C>T	ENST00000296266.3	+	2	246	c.54C>T	c.(52-54)atC>atT	p.I18I	IFT122_ENST00000440957.2_5'UTR|IFT122_ENST00000431818.2_5'UTR|IFT122_ENST00000504021.1_Silent_p.I18I|IFT122_ENST00000349441.2_Silent_p.I18I|IFT122_ENST00000347300.2_Silent_p.I18I|IFT122_ENST00000507564.1_Silent_p.I18I|IFT122_ENST00000348417.2_Silent_p.I18I	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	18					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TAAATGACATCGCATTTAAGC	0.393000													40	112					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17462284	17462284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:17462284G>A	ENST00000262545.2	+	12	1801	c.1486G>A	c.(1486-1488)Ggg>Agg	p.G496R	PCSK2_ENST00000536609.1_Missense_Mutation_p.G461R|PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000377899.1_Missense_Mutation_p.G477R	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	496					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGCCTGTGAGGGGAAGGAAAA	0.522000													24	86					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7711159	7711159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7711159G>A	ENST00000441779.2	+	16	1451	c.1414G>A	c.(1414-1416)Gag>Aag	p.E472K	STXBP2_ENST00000221283.5_Missense_Mutation_p.E461K|STXBP2_ENST00000602355.1_5'UTR|STXBP2_ENST00000414284.2_Missense_Mutation_p.E458K	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	461					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						CAGCCGGCTGGAGCCGAGAGA	0.672000													3	5					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374337	31374337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31374337C>T	ENST00000268296.4	+	13	1562	c.1441C>T	c.(1441-1443)Ccc>Tcc	p.P481S	ITGAX_ENST00000562522.1_Missense_Mutation_p.P481S	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	481					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CATCGGGGCCCCCCATTACTA	0.677000													18	85					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113562887	113562887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113562887C>T	ENST00000416899.2	+	13	2331	c.2205C>T	c.(2203-2205)gaC>gaT	p.D735D	MUSK_ENST00000374448.4_Silent_p.D743D|MUSK_ENST00000189978.5_Silent_p.D743D			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	743	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						AAATTGCCGACTTTGGCCTCT	0.483000													67	161					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56235370	56235370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56235370G>A	ENST00000332836.2	-	4	2162	c.2135C>T	c.(2134-2136)cCa>cTa	p.P712L		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	712						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTTGCACATTGGATGTTTCAG	0.478000													47	68					0	0	1	0	0
FRRS1L	23732	broad.mit.edu	37	9	111903821	111903821	+	Missense_Mutation	SNP	G	G	A	rs143745415		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111903821G>A	ENST00000374581.3	-	4	663	c.664C>T	c.(664-666)Cgc>Tgc	p.R222C		NM_014334.2	NP_055149.2	Q9P0K9	CI004_HUMAN	ferric-chelate reductase 1-like	222	DOMON.					integral to membrane											TGCTGTATGCGGACCCTGCCA	0.448000													48	60					0	0	1	0	0
HSD17B3	3293	broad.mit.edu	37	9	99003048	99003048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:99003048C>T	ENST00000375263.3	-	10	861	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	HSD17B3_ENST00000464104.1_5'UTR|HSD17B3_ENST00000375262.2_Intron	NM_000197.1	NP_000188.1	P37058	DHB3_HUMAN	hydroxysteroid (17-beta) dehydrogenase 3	272					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	ACCAAGATTTCATGGGCAAGG	0.473000													21	89					0	0	1	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114107626	114107626	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:114107626G>A	ENST00000375418.3	-	1	213	c.127C>T	c.(127-129)Ctg>Ttg	p.L43L		NM_138430.3	NP_612439.2	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	43					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			AGGTGGTCCAGGCCCCCGGAA	0.612000													26	71					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862327	14862327	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14862327C>T	ENST00000285046.5	+	1	1859	c.1749C>T	c.(1747-1749)ctC>ctT	p.L583L	FGD5_ENST00000543601.1_Silent_p.L342L	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	583					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding	p.L342L(1)|p.L583L(1)		NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						AGGACAATCTCTCTCTGTCGT	0.562000													17	59					0	0	1	0	0
BOP1	23246	broad.mit.edu	37	8	145512850	145512850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145512850C>T	ENST00000307404.5	-	2	264	c.235G>A	c.(235-237)Gag>Aag	p.E79K	BOP1_ENST00000529231.1_Silent_p.T6T	NM_015201.3	NP_056016.1	Q14137	BOP1_HUMAN	block of proliferation 1	79					cell proliferation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	nucleoplasm|PeBoW complex	protein binding			lung(1)|urinary_tract(2)	3	all_cancers(97;4.06e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;2.61e-39)|all cancers(56;1.37e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.087)			TCTCCCTCCTCGTCGCCTTCG	0.612000													25	98					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66504220	66504220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:66504220C>T	ENST00000360242.5	+	2	337	c.220C>T	c.(220-222)Cgc>Tgc	p.R74C	CCDC102B_ENST00000358653.5_Missense_Mutation_p.R74C|CCDC102B_ENST00000319445.6_Missense_Mutation_p.R74C|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000584156.1_Missense_Mutation_p.R74C	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	74										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				TGAAGAACTTCGCCTGCGGGA	0.483000													33	173					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137852557	137852557	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:137852557G>A	ENST00000409968.1	+	4	1243	c.1065G>A	c.(1063-1065)ggG>ggA	p.G355G	THSD7B_ENST00000272643.3_Silent_p.G355G|THSD7B_ENST00000413152.2_Silent_p.G324G|THSD7B_ENST00000543459.1_Silent_p.G214G					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCCGTTCAGGGAGTCTCTTGC	0.537000													30	64					0	0	1	0	0
TTC9C	283237	broad.mit.edu	37	11	62502996	62502996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62502996C>T	ENST00000316461.4	+	2	691	c.381C>T	c.(379-381)gcC>gcT	p.A127A	TTC9C_ENST00000513247.2_3'UTR|TTC9C_ENST00000532583.1_Silent_p.A127A	NM_173810.3	NP_776171.1	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	127							binding			breast(1)|endometrium(1)|lung(2)|ovary(1)|pancreas(1)	6						ATGACCAGGCCCGCCACTACC	0.512000													15	23					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9916206	9916206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9916206G>A	ENST00000396573.2	-	11	2392	c.2083C>T	c.(2083-2085)Cgg>Tgg	p.R695W	GRIN2A_ENST00000535259.1_Missense_Mutation_p.R538W|GRIN2A_ENST00000404927.2_Missense_Mutation_p.R695W|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R695W|GRIN2A_ENST00000330684.3_Missense_Mutation_p.R695W|GRIN2A_ENST00000396575.2_Missense_Mutation_p.R695W	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	695					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAGTTATTCCGAATGTTTCTC	0.458000													28	75					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799376	45799376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45799376G>A	ENST00000553795.1	-	4	803	c.495C>T	c.(493-495)gcC>gcT	p.A165A	OR13A1_ENST00000536058.1_Silent_p.A165A|OR13A1_ENST00000374401.2_Silent_p.A165A	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						GCAGCCACACGGCTGTGGCCA	0.597000													14	54					0	0	1	0	0
GPR21	2844	broad.mit.edu	37	9	125797634	125797634	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125797634C>T	ENST00000373642.1	+	1	829	c.789C>T	c.(787-789)atC>atT	p.I263I	RABGAP1_ENST00000373647.4_Intron|RABGAP1_ENST00000373643.5_Intron|RABGAP1_ENST00000493854.1_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	263						integral to plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						TATTTTACATCCTCTGGTTGC	0.507000													10	160					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77359766	77359766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77359766C>T	ENST00000282849.5	-	13	2447	c.2029G>A	c.(2029-2031)Gaa>Aaa	p.E677K		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	677	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AAATTACCTTCCACTTTTGTA	0.373000													10	53					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54817803	54817803	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54817803C>T	ENST00000545554.1	+	24	5514	c.5514C>T	c.(5512-5514)gtC>gtT	p.V1838V	UNC13C_ENST00000537900.1_Silent_p.V1836V|UNC13C_ENST00000260323.11_Silent_p.V1838V			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1838					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TCAGTGGGGTCCTGGATGAGC	0.388000													5	32					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4645066	4645066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4645066C>T	ENST00000433935.1	+	3	839	c.782C>T	c.(781-783)cCc>cTc	p.P261L	ZMYND15_ENST00000573751.2_Missense_Mutation_p.P261L|ZMYND15_ENST00000269289.6_Missense_Mutation_p.P261L|ZMYND15_ENST00000592813.1_Missense_Mutation_p.P261L	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	261							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						TCTGGGGATCCCCGAAAGCCC	0.622000													19	20					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106865267	106865267	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106865267C>T	ENST00000369701.3	+	7	1433	c.1206C>T	c.(1204-1206)ttC>ttT	p.F402F		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	402						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AATATATCTTCATTCAGGTGA	0.502000													35	128					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1115683	1115683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1115683C>T	ENST00000379290.1	+	6	642	c.469C>T	c.(469-471)Ccc>Tcc	p.P157S	TTLL10_ENST00000379289.1_Missense_Mutation_p.P157S|TTLL10_ENST00000379288.3_Missense_Mutation_p.P84S			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	157	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCGGCCGGGGCCCTTCTTCTA	0.697000													4	12					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64527202	64527202	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64527202C>T	ENST00000498707.1	-	34	5634	c.5292_splice	c.e34+1	p.K1764_splice	ADAMTS9_ENST00000295903.4_Splice_Site_p.K1736_splice	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1764	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGACATTCACCTTCAGAAGCT	0.398000													36	112					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206331107	206331107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206331107G>A	ENST00000360218.2	+	8	1075	c.971G>A	c.(970-972)gGg>gAg	p.G324E	CTSE_ENST00000358184.2_Silent_p.G371G|CTSE_ENST00000361052.3_Silent_p.G376G|CTSE_ENST00000432969.2_Missense_Mutation_p.G249E	NM_148964.2	NP_683865.1	P14091	CATE_HUMAN	cathepsin E	152					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GGATCCTGGGGGATGTCTTCA	0.562000													55	129					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97485045	97485045	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:97485045C>T	ENST00000376705.2	+	2	1033	c.1009C>T	c.(1009-1011)Ctg>Ttg	p.L337L		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	337						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					AAACACCATCCTGTTGCAGAG	0.488000													32	94					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180489	124180489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124180489G>A	ENST00000357821.2	-	1	244	c.174C>T	c.(172-174)ccC>ccT	p.P58P		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AATAGTACATGGGGGTGTGAA	0.483000													18	73					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150881820	150881820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:150881820C>T	ENST00000474524.1	+	8	1286	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F	MED12L_ENST00000309237.4_Silent_p.F416F|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000422248.2_Silent_p.F416F	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	416					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACACGGCTTTCAATCAGCAGG	0.507000													33	75					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902441	40902441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40902441C>T	ENST00000324001.7	-	7	2088	c.1818G>A	c.(1816-1818)ccG>ccA	p.P606P	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	606	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGGGCACCTTCGGGAGTTGCA	0.537000													84	209					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43788217	43788217	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43788217G>A	ENST00000261488.6	-	17	2418	c.1841C>T	c.(1840-1842)cCa>cTa	p.P614L	ENOX1_ENST00000412891.1_Missense_Mutation_p.P614L	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	614					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GAACATGCGTGGCAGCCTCAT	0.428000													13	111					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55356487	55356487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55356487C>T	ENST00000524622.1	-	7	1442	c.781G>A	c.(781-783)Gat>Aat	p.D261N	TESPA1_ENST00000316577.8_Missense_Mutation_p.D399N|TESPA1_ENST00000449076.1_Missense_Mutation_p.D399N|TESPA1_ENST00000532804.1_Missense_Mutation_p.D261N|TESPA1_ENST00000531122.1_Missense_Mutation_p.D261N	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	399																	CACTGTGGATCTTCTATGGGC	0.517000													27	103					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122626202	122626202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:122626202C>T	ENST00000263461.6	+	8	1362	c.1116C>T	c.(1114-1116)gcC>gcT	p.A372A		NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	372						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						ATGCAGCCGCCCTCGTAGTGA	0.463000													44	104					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123419462	123419462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123419462G>A	ENST00000360772.3	-	19	3231	c.2853C>T	c.(2851-2853)gtC>gtT	p.V951V	MYLK_ENST00000360304.3_Silent_p.V951V|MYLK_ENST00000475616.1_Silent_p.V951V|MYLK_ENST00000346322.5_Silent_p.V882V|MYLK_ENST00000359169.1_Silent_p.V951V			Q15746	MYLK_HUMAN	myosin light chain kinase	951	5 X 28 AA approximate tandem repeats.|Actin-binding (calcium/calmodulin- sensitive) (By similarity).|Calmodulin-binding (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGCGAAAATCGACCTGCTGGG	0.597000													24	50					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10753581	10753581	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10753581C>T	ENST00000586078.1	+	22	2132	c.2023C>T	c.(2023-2025)Ctg>Ttg	p.L675L	SLC44A2_ENST00000335757.5_Intron|SLC44A2_ENST00000407327.4_Intron	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	675					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	AGGTGAGGACCTGGAAAGGAA	0.637000													3	14					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53516948	53516948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53516948C>T	ENST00000301466.3	+	13	1380	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	440					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						TCTTCTGCTTCGTCCTGGGGT	0.592000													20	66					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43896592	43896592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43896592C>T	ENST00000261488.6	-	11	1766	c.1189G>A	c.(1189-1191)Gaa>Aaa	p.E397K	ENOX1_ENST00000540032.1_Missense_Mutation_p.E210K|ENOX1_ENST00000412891.1_Missense_Mutation_p.E397K	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	397					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		ATTTCTTCTTCGCGGCGGATG	0.478000													30	58					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54963142	54963142	+	Silent	SNP	C	C	T	rs151025806	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54963142C>T	ENST00000243052.3	+	4	838	c.402C>T	c.(400-402)ttC>ttT	p.F134F	PDE1B_ENST00000550620.1_Silent_p.F114F|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Silent_p.F93F	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	134					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						CTGGGATCTTCGTGGAACGGT	0.622000													11	32					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56078540	56078540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56078540C>T	ENST00000429804.2	-	9	2202	c.1642G>A	c.(1642-1644)Ggt>Agt	p.G548S	CTCFL_ENST00000422109.2_3'UTR|CTCFL_ENST00000433949.2_Missense_Mutation_p.G598S|CTCFL_ENST00000502686.2_Missense_Mutation_p.G336S|CTCFL_ENST00000371196.2_Missense_Mutation_p.G598S|CTCFL_ENST00000423479.2_Missense_Mutation_p.G598S|CTCFL_ENST00000426658.2_3'UTR|CTCFL_ENST00000243914.3_Missense_Mutation_p.G598S	NM_001269046.1	NP_001255975.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	598					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			TCCTTCTGACCCTTTGTGGCT	0.498000													52	103					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117566802	117566802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117566802C>T	ENST00000254029.3	+	13	2191	c.1796C>T	c.(1795-1797)cCa>cTa	p.P599L	WDR44_ENST00000371822.5_Missense_Mutation_p.P574L|WDR44_ENST00000371825.3_Missense_Mutation_p.P599L	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	599						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						CGGCAACGGCCATTTTGCAAA	0.348000													61	58					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21860965	21860965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21860965G>A	ENST00000399982.2	-	33	6536	c.6472C>T	c.(6472-6474)Cgt>Tgt	p.R2158C	CHD8_ENST00000430710.3_Missense_Mutation_p.R1879C|CHD8_ENST00000557364.1_Missense_Mutation_p.R2158C	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2158					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ATCAGGACACGATCCTGAATG	0.463000													12	151					0	0	1	0	0
GP9	2815	broad.mit.edu	37	3	128780587	128780587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:128780587C>T	ENST00000307395.4	+	3	227	c.5C>T	c.(4-6)cCt>cTt	p.P2L		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	2					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	TGTCCCATGCCTGCCTGGGGA	0.682000													6	16					0	0	1	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086676	46086676	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46086676G>A	ENST00000360770.3	-	1	168	c.128C>T	c.(127-129)tCc>tTc	p.S43F	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	43	23 X 5 AA approximate repeats.					keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						CACACACACGGAGGACTGGCA	0.657000													15	45					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19194885	19194885	+	Missense_Mutation	SNP	G	G	A	rs149672382		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19194885G>A	ENST00000562034.1	+	3	3982	c.184G>A	c.(184-186)Gat>Aat	p.D62N	SYT17_ENST00000568115.1_Missense_Mutation_p.D62N|SYT17_ENST00000562711.2_Missense_Mutation_p.D119N|SYT17_ENST00000355377.2_Missense_Mutation_p.D123N			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	123						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						TCCACTCATCGATATTAAACC	0.527000													15	130					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159283541	159283541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159283541C>T	ENST00000332217.5	-	1	908	c.909G>A	c.(907-909)caG>caA	p.Q303Q		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					CCCCACGGCTCTGTGCAGAGC	0.433000													39	82					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15374430	15374430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:15374430C>T	ENST00000341776.2	+	2	372	c.128C>T	c.(127-129)tCc>tTc	p.S43F	JARID2_ENST00000397311.3_5'UTR	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	43					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				TTCAAGAATTCCCAGAAGAGG	0.443000													65	131					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3656551	3656551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3656551G>A	ENST00000335312.3	-	6	561	c.473C>T	c.(472-474)tCc>tTc	p.S158F	PIP5K1C_ENST00000539785.1_Missense_Mutation_p.S158F|PIP5K1C_ENST00000589578.1_Missense_Mutation_p.S158F|PIP5K1C_ENST00000587482.1_5'UTR|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.S158F	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	158	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		ATTGCACAGGGAGTACTGGAA	0.622000													23	63					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501062	90501062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90501062G>A	ENST00000325643.5	+	4	1726	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1									p.E554K(1)									TACATCCCAGGAGAGGACACA	0.562000													52	127					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663440	34663440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34663440G>A	ENST00000488417.1	+	2	1055	c.935G>A	c.(934-936)aGg>aAg	p.R312K	C1orf94_ENST00000373374.3_Missense_Mutation_p.R122K	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	122							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				GCTCAGAAGAGGCAGCTCCCA	0.612000													15	39					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569725	241569725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241569725G>A	ENST00000319838.5	+	6	1298	c.356G>A	c.(355-357)cGg>cAg	p.R119Q	GPR35_ENST00000430267.1_Missense_Mutation_p.R119Q|GPR35_ENST00000407714.1_Missense_Mutation_p.R119Q|GPR35_ENST00000403859.1_Missense_Mutation_p.R119Q|GPR35_ENST00000438013.2_Missense_Mutation_p.R150Q	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	119						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GTGGCCGTGCGGCACCCGCTG	0.706000													9	25					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95947690	95947690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:95947690G>A	ENST00000317620.9	+	13	1702	c.1569G>A	c.(1567-1569)ggG>ggA	p.G523G	PROM2_ENST00000542147.1_Silent_p.G523G|PROM2_ENST00000317668.4_Silent_p.G523G|PROM2_ENST00000403131.2_Silent_p.G523G	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	523						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						ACACCCCAGGGAACCTGCCCC	0.627000													8	113					0	0	1	0	0
TPD52L3	89882	broad.mit.edu	37	9	6328916	6328916	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:6328916G>A	ENST00000344545.5	+	1	568	c.321G>A	c.(319-321)agG>agA	p.R107R	TPD52L3_ENST00000381428.1_Silent_p.R107R|TPD52L3_ENST00000314556.3_Silent_p.R107R	NM_033516.5	NP_277051.3	Q96J77	TPD55_HUMAN	tumor protein D52-like 3	107							protein binding			large_intestine(1)|lung(9)|skin(1)	11		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		TCATCTGCAGGAAGCTTGGAG	0.507000													30	52					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92953005	92953005	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92953005C>T	ENST00000544910.1	+	22	2068	c.1848C>T	c.(1846-1848)taC>taT	p.Y616Y	CCDC132_ENST00000535481.1_Silent_p.Y366Y|CCDC132_ENST00000541136.1_Silent_p.Y457Y|CCDC132_ENST00000305866.5_Silent_p.Y646Y	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	646										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGATTATTACTTGTATGCAA	0.269000													9	38					0	0	1	0	0
IGLV2-18	28814	broad.mit.edu	37	22	23077472	23077472	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23077472C>T	ENST00000390310.2	+	0	262																											CTGATCGCTTCTCTGGGTCCA	0.557000													114	237					0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048773	6048773	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6048773G>A	ENST00000316650.5	-	1	198	c.162C>T	c.(160-162)atC>atT	p.I54I		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I54I(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGGATGGTGATCAGGAGGG	0.612000													34	60					0	0	1	0	0
NMNAT2	23057	broad.mit.edu	37	1	183230174	183230174	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183230174T>C	ENST00000287713.6	-	10	1118	c.784A>G	c.(784-786)Aac>Gac	p.N262D	NMNAT2_ENST00000294868.4_Missense_Mutation_p.N257D	NM_015039.3	NP_055854.1	Q9BZQ4	NMNA2_HUMAN	nicotinamide nucleotide adenylyltransferase 2	262					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	18						atgggatggttgatgtcatcc	0.458000													41	94					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25399814	25399814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25399814G>A	ENST00000255324.5	+	16	2201	c.2149G>A	c.(2149-2151)Gaa>Aaa	p.E717K	RNF17_ENST00000381921.1_Missense_Mutation_p.E717K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	717					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTATAAAAGTGAAGATGGAGA	0.358000													36	100					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52942420	52942420	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52942420G>A	ENST00000332323.6	+	4	1807	c.1746G>A	c.(1744-1746)agG>agA	p.R582R	ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Silent_p.R569R|ZNF534_ENST00000301085.4_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	582					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						CGCGACATAGGAATATTCATA	0.443000													9	17					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529496	5529496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5529496C>T	ENST00000311659.4	-	2	1440	c.1293G>A	c.(1291-1293)ggG>ggA	p.G431G	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	431										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGAGCTTTTCCCTGCACCAT	0.517000													41	81					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731945	140731945	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140731945G>A	ENST00000523390.1	+	1	2118	c.2118G>A	c.(2116-2118)gcG>gcA	p.A706A	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATTCTAGCGATCGCCCTGC	0.612000													63	179					0	0	1	0	0
FAM135A	57579	broad.mit.edu	37	6	71191790	71191790	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:71191790C>T	ENST00000418814.2	+	10	1370	c.756C>T	c.(754-756)ttC>ttT	p.F252F	FAM135A_ENST00000505769.1_Silent_p.F252F|FAM135A_ENST00000505868.1_Silent_p.F252F|FAM135A_ENST00000361499.3_Silent_p.F252F|FAM135A_ENST00000370479.3_Silent_p.F209F|FAM135A_ENST00000457062.2_Silent_p.F209F	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	252										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						TGCTAGCCTTCAAGGGATTGC	0.393000													30	62					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5355600	5355600	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:5355600G>A	ENST00000399537.4	-	25	7197	c.6849C>T	c.(6847-6849)gaC>gaT	p.D2283D	TNRC18_ENST00000430969.1_Silent_p.D2283D			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2283							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GTATCTTATAGTCAGGGGGCA	0.612000													6	22					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642007	57642007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57642007G>A	ENST00000254181.4	+	4	2418	c.1964G>A	c.(1963-1965)gGa>gAa	p.G655E	USP29_ENST00000598197.1_Missense_Mutation_p.G655E	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	655					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGGACCAGGGAGACATTTCT	0.493000													14	39					0	0	1	0	0
FETUB	26998	broad.mit.edu	37	3	186364116	186364116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186364116C>T	ENST00000265029.3	+	5	775	c.674C>T	c.(673-675)tCa>tTa	p.S225L	RP11-134F2.2_ENST00000455926.1_RNA|FETUB_ENST00000450521.1_Missense_Mutation_p.S225L|FETUB_ENST00000382134.3_Missense_Mutation_p.S160L|FETUB_ENST00000539949.1_Missense_Mutation_p.S77L|FETUB_ENST00000382136.3_Missense_Mutation_p.S188L|RP11-134F2.2_ENST00000428501.1_RNA	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	225	Cystatin fetuin-B-type 2.					extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		AGCAGCTGTTCACTTCAGTCC	0.408000													47	125					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56090698	56090698	+	Silent	SNP	G	G	A	rs142311782	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56090698G>A	ENST00000257880.7	-	13	2073	c.1854C>T	c.(1852-1854)gcC>gcT	p.A618A	ITGA7_ENST00000347027.6_Silent_p.A568A|ITGA7_ENST00000394230.2_Silent_p.A578A|ITGA7_ENST00000452168.2_Silent_p.A481A|ITGA7_ENST00000553804.1_Silent_p.A578A|ITGA7_ENST00000555728.1_Silent_p.A618A|ITGA7_ENST00000394229.2_Silent_p.A574A|ITGA7_ENST00000257879.6_Silent_p.A574A			Q13683	ITA7_HUMAN	integrin, alpha 7	618					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCTGGAACATGGCGTCTCCAC	0.572000													10	35					0	0	1	0	0
IL10RA	3587	broad.mit.edu	37	11	117870052	117870052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117870052G>A	ENST00000227752.3	+	7	1553	c.1433G>A	c.(1432-1434)gGg>gAg	p.G478E	IL10RA_ENST00000545409.1_Missense_Mutation_p.G329E|IL10RA_ENST00000533700.1_3'UTR|IL10RA_ENST00000541785.1_Missense_Mutation_p.G458E	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	478						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CCCAAATTCGGGAGATGCCTG	0.562000													19	69					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108618544	108618544	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108618544C>T	ENST00000332082.4	+	6	1529	c.711C>T	c.(709-711)ttC>ttT	p.F237F	WSCD2_ENST00000261400.3_Silent_p.F237F|WSCD2_ENST00000547525.1_Silent_p.F237F|WSCD2_ENST00000549903.1_Silent_p.F237F			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	237	WSC 2.					integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						GGGGCTGCTTCCGCAGGCCCG	0.532000													27	93					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337651	102337651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:102337651C>T	ENST00000369138.1	+	11	2151	c.1661C>T	c.(1660-1662)tCc>tTc	p.S554F	GRIK2_ENST00000413795.1_Missense_Mutation_p.S554F|GRIK2_ENST00000369134.4_Missense_Mutation_p.S505F|GRIK2_ENST00000369137.3_Intron|GRIK2_ENST00000318991.6_Missense_Mutation_p.S554F|GRIK2_ENST00000421544.1_Missense_Mutation_p.S554F	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	554					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GGCGTCTTCTCCTTCCTGAAT	0.458000													58	121					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67183865	67183865	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67183865G>A	ENST00000269081.4	-	20	3196	c.2287C>T	c.(2287-2289)Cgc>Tgc	p.R763C	ABCA10_ENST00000416101.2_3'UTR	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	763					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					TTTAAGAAGCGAAGTGTTGCC	0.383000													33	85					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21213507	21213507	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21213507G>T	ENST00000574002.1	-	12	1687	c.1205C>A	c.(1204-1206)tCc>tAc	p.S402Y	ZP2_ENST00000219593.4_Missense_Mutation_p.S402Y|ZP2_ENST00000574091.1_Missense_Mutation_p.S402Y|AF001550.7_ENST00000572747.1_RNA			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	402	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		AGGCTGGCAGGATGAGTTTCC	0.542000													12	39					7.03913e-09	7.0643e-09	1	1	0
SLC16A3	9123	broad.mit.edu	37	17	80195264	80195264	+	Silent	SNP	G	G	A	rs5822442		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80195264G>A	ENST00000581287.1	+	3	2940	c.618G>A	c.(616-618)ccG>ccA	p.P206P	SLC16A3_ENST00000392341.1_Silent_p.P206P|SLC16A3_ENST00000582743.1_Silent_p.P206P|SLC16A3_ENST00000392339.1_Silent_p.P206P	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	206					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	CGGCCCAGCCGGGCTCGGGGC	0.721000													3	6					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19339423	19339423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19339423C>T	ENST00000252575.5	+	8	3037	c.2994C>T	c.(2992-2994)acC>acT	p.T998T	NCAN_ENST00000538881.1_Silent_p.T449T	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	998					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			TGCCAGGGACCCCTATGAATG	0.642000													15	54					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87969864	87969864	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:87969864C>T	ENST00000369577.3	+	8	6560	c.6517C>T	c.(6517-6519)Cga>Tga	p.R2173*	ZNF292_ENST00000339907.4_Nonsense_Mutation_p.R2168*	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GAAAGAATTTCGATGTCAGGT	0.368000													60	112					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83180398	83180398	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:83180398C>T	ENST00000398309.2	-	20	2620	c.2150G>A	c.(2149-2151)cGa>cAa	p.R717Q	DLG2_ENST00000524982.1_Missense_Mutation_p.R713Q|DLG2_ENST00000543673.1_Missense_Mutation_p.R822Q|DLG2_ENST00000418306.2_Missense_Mutation_p.R596Q|DLG2_ENST00000532653.1_Missense_Mutation_p.R699Q|DLG2_ENST00000426717.2_Missense_Mutation_p.R181Q|DLG2_ENST00000280241.8_Missense_Mutation_p.R756Q|DLG2_ENST00000376106.3_Missense_Mutation_p.R181Q|DLG2_ENST00000531015.1_Missense_Mutation_p.R684Q|DLG2_ENST00000330014.6_Missense_Mutation_p.R638Q|DLG2_ENST00000537455.1_Missense_Mutation_p.R467Q|DLG2_ENST00000376104.2_Missense_Mutation_p.R822Q|DLG2_ENST00000404783.3_Missense_Mutation_p.R195Q	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	717	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CTCGTAGTCTCGCTTTGGCCT	0.388000													27	121					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102968013	102968013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102968013G>A	ENST00000233954.1	+	11	1574	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K		NM_016232.4	NP_057316.3	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	435	TIR.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						CACTGCAGTGGAAACCAACAT	0.413000													21	66					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454619	84454619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:84454619G>A	ENST00000377084.2	-	1	1909	c.1024C>T	c.(1024-1026)Cct>Tct	p.P342S		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	342	LRRNT 2.					integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CAGCCCCCAGGGCAGGGTAAA	0.537000													8	103					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18393374	18393374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:18393374G>A	ENST00000440756.2	-	16	3131	c.3029C>T	c.(3028-3030)tCg>tTg	p.S1010L	PSD3_ENST00000428502.2_Missense_Mutation_p.S337L|PSD3_ENST00000327040.8_Missense_Mutation_p.S1008L|PSD3_ENST00000286485.8_Missense_Mutation_p.S474L|PSD3_ENST00000523619.1_Missense_Mutation_p.S943L			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	1009					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACTCGAGTGCGACTTCTTCAG	0.498000													29	66					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6333529	6333529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6333529C>T	ENST00000301452.4	-	1	111	c.34G>A	c.(34-36)Gtg>Atg	p.V12M		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	12						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						CACCAGTCCACCTCGGAGCTC	0.617000													6	12					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47950683	47950683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47950683G>A	ENST00000426837.2	-	10	5366	c.5279C>T	c.(5278-5280)tCa>tTa	p.S1760L	MAP4_ENST00000264724.11_Missense_Mutation_p.S350L|MAP4_ENST00000383737.4_Missense_Mutation_p.S343L|MAP4_ENST00000360240.6_Intron|MAP4_ENST00000395734.3_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	626					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGGTGTCTTTGATTCAGATTT	0.428000													29	94					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596346	24596346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24596346C>T	ENST00000535378.1	-	4	1171	c.529G>A	c.(529-531)Ggc>Agc	p.G177S	KIAA0319_ENST00000543707.1_Missense_Mutation_p.G186S|KIAA0319_ENST00000430948.2_Missense_Mutation_p.G141S|KIAA0319_ENST00000378214.3_Missense_Mutation_p.G186S|KIAA0319_ENST00000537886.1_Missense_Mutation_p.G186S	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	186					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GGCAGTAGGCCCCAGTCCGTG	0.617000													17	35					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49812813	49812813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49812813C>T	ENST00000249601.4	-	1	325	c.29G>A	c.(28-30)aGg>aAg	p.R10K	ARHGAP22_ENST00000417912.2_Missense_Mutation_p.R10K|ARHGAP22_ENST00000491108.1_5'UTR|ARHGAP22_ENST00000435790.2_Intron	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	10					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTTACCCCTCCTGGCCTGCCT	0.607000													25	70					0	0	1	0	0
AADAC	13	broad.mit.edu	37	3	151542595	151542595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151542595G>A	ENST00000232892.6	+	4	702	c.576G>A	c.(574-576)ggG>ggA	p.G192G	AADAC_ENST00000488869.1_Silent_p.G192G|RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	192					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GTGCAGGAGGGAATTTAGCTG	0.338000													13	51					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124080952	124080952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:124080952C>T	ENST00000373823.3	+	17	1890	c.985C>T	c.(985-987)Ctt>Ttt	p.L329F	GSN_ENST00000373807.1_Missense_Mutation_p.L111F|GSN_ENST00000341272.2_Missense_Mutation_p.L329F|GSN_ENST00000412819.1_Missense_Mutation_p.L329F|GSN_ENST00000373808.2_Missense_Mutation_p.L329F|GSN_ENST00000436847.1_Missense_Mutation_p.L340F|GSN_ENST00000373818.4_Missense_Mutation_p.L380F|GSN_ENST00000394353.2_Missense_Mutation_p.L340F|GSN_ENST00000545652.1_Missense_Mutation_p.L337F|GSN_ENST00000449733.1_Missense_Mutation_p.L329F			P06396	GELS_HUMAN	gelsolin	380					actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						GGTCTCGGTCCTTCCTGAGGG	0.632000													18	51					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25479434	25479434	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25479434G>A	ENST00000453082.2	+	0	1891				SNORD115-35_ENST00000365122.1_RNA	NR_003343.1																						GAAGAGAGGTGATGACTTAAA	0.502000													113	355					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241831098	241831098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241831098G>A	ENST00000307486.8	-	2	248	c.150C>T	c.(148-150)ttC>ttT	p.F50F	C2orf54_ENST00000388934.4_Silent_p.F199F|C2orf54_ENST00000402775.2_Silent_p.F31F			Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	199										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		GCACCACGTGGAAGCTGATTG	0.627000													39	73					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124389907	124389907	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124389907A>G	ENST00000338354.3	+	45	5645	c.5539A>G	c.(5539-5541)Ata>Gta	p.I1847V	DMBT1_ENST00000344338.3_Missense_Mutation_p.I1837V|DMBT1_ENST00000368955.3_Missense_Mutation_p.I1837V|DMBT1_ENST00000359586.6_Missense_Mutation_p.I567V|DMBT1_ENST00000330163.4_Missense_Mutation_p.I1219V|DMBT1_ENST00000368956.2_Missense_Mutation_p.I1219V|DMBT1_ENST00000368909.3_Missense_Mutation_p.I1847V			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1847	CUB 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TACCAGGCAAATATTTACATC	0.408000													26	51					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94716543	94716543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94716543C>T	ENST00000304338.3	+	15	1800	c.1646C>T	c.(1645-1647)aCt>aTt	p.T549I		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	549						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GCTTCACGAACTCTATGCATT	0.348000													27	54					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61843365	61843365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61843365C>T	ENST00000280772.1	-	33	4276	c.4085G>A	c.(4084-4086)gGa>gAa	p.G1362E	ANK3_ENST00000355288.2_Missense_Mutation_p.G496E|ANK3_ENST00000503366.1_Missense_Mutation_p.G1363E|ANK3_ENST00000373827.2_Missense_Mutation_p.G1356E	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1362					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.G496E(2)|p.G1362E(2)		NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AATAGGTTTTCCTTCCAGAAC	0.299000													23	65					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501775	90501775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90501775G>A	ENST00000325643.5	+	4	2439	c.2373G>A	c.(2371-2373)atG>atA	p.M791I		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CCTGGCTCATGGCCAAATGTG	0.572000													12	57					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63966615	63966615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:63966615C>T	ENST00000443617.2	-	38	7859	c.7772G>A	c.(7771-7773)cGa>cAa	p.R2591Q		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2591					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GGCTTGCGCTCGTTCCAGATC	0.448000													11	67					0	0	1	0	0
OR10K2	391107	broad.mit.edu	37	1	158389857	158389857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158389857G>A	ENST00000314902.2	-	1	799	c.800C>T	c.(799-801)tCc>tTc	p.S267F		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					CTGGCTTGAGGAGTAGTTGGA	0.398000													25	74					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995456	140995456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140995456C>T	ENST00000285879.4	+	4	2552	c.2266C>T	c.(2266-2268)Ccc>Tcc	p.P756S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	756							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGAGTCTTCCCCAGAGTTT	0.547000										HNSCC(15;0.026)			96	101					0	0	1	0	0
LEMD1	93273	broad.mit.edu	37	1	205350899	205350899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205350899C>T	ENST00000367153.4	-	6	535	c.433G>A	c.(433-435)Gag>Aag	p.E145K	LEMD1_ENST00000367154.1_Silent_p.S97S|LEMD1_ENST00000367152.1_Missense_Mutation_p.E104K|LEMD1_ENST00000367149.3_Silent_p.S56S|LEMD1_ENST00000391936.2_Silent_p.S97S|LEMD1_ENST00000367151.2_Missense_Mutation_p.E104K|LEMD1_ENST00000476884.1_5'UTR|LEMD1-AS1_ENST00000447832.1_RNA	NM_001199050.1	NP_001185979.1	Q68G75	LEMD1_HUMAN	LEM domain containing 1	145						integral to membrane|nuclear envelope				breast(1)|lung(2)	3	Breast(84;0.247)		BRCA - Breast invasive adenocarcinoma(75;0.0938)			CTCCAGCTCTCGATAGTCTGG	0.478000													69	162					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57136731	57136731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:57136731C>T	ENST00000439986.4	-	4	411	c.374G>A	c.(373-375)cGg>cAg	p.R125Q	CCBE1_ENST00000398179.2_5'UTR	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	125					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				CTCCCGCTTCCGGTGTCTCTC	0.537000													26	136					0	0	1	0	0
INTS12	57117	broad.mit.edu	37	4	106621017	106621017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:106621017G>A	ENST00000451321.2	-	2	625	c.146C>T	c.(145-147)cCa>cTa	p.P49L	INTS12_ENST00000394735.1_Missense_Mutation_p.P49L|INTS12_ENST00000340139.5_Missense_Mutation_p.P49L	NM_001142471.1	NP_001135943.1	Q96CB8	INT12_HUMAN	integrator complex subunit 12	49					snRNA processing	integrator complex	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		CTTTTGAGATGGACGGTAACT	0.388000													27	226					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46937265	46937265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46937265C>T	ENST00000429979.1	-	6	1514	c.910G>A	c.(910-912)Gaa>Aaa	p.E304K	KIAA0226L_ENST00000378784.4_Missense_Mutation_p.E237K|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.E304K|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.E304K|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.E169K|KIAA0226L_ENST00000409879.2_Missense_Mutation_p.E147K|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.E147K|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.E304K|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.E304K	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	304										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						ATAACAAATTCATCAACATCG	0.423000													9	38					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413716	48413716	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48413716G>A	ENST00000249598.1	-	2	1311	c.1152C>T	c.(1150-1152)ttC>ttT	p.F384F		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	384					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CCTTTGTGGGGAACTTGAGAT	0.577000													6	39					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145562487	145562487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145562487C>T	ENST00000355594.4	+	10	2262	c.2175C>T	c.(2173-2175)tcC>tcT	p.S725S		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	725										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAGCGGAGTCCCTGGAGGAGC	0.667000													3	18					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663684	169663684	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169663684G>A	ENST00000483289.2	-	0	3610				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						CAGGGCAGGAGCCCCTGTCAG	0.443000													13	92					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139907985	139907985	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139907985G>A	ENST00000265662.5	-	29	4625	c.4478C>T	c.(4477-4479)tCc>tTc	p.S1493F	ABCA2_ENST00000371605.3_Missense_Mutation_p.S1492F|ABCA2_ENST00000341511.6_Missense_Mutation_p.S1493F			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1492					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GTGGTACTGGGAAGGTGACAG	0.687000													4	12					0	0	1	0	0
NT5M	56953	broad.mit.edu	37	17	17250254	17250254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:17250254C>T	ENST00000389022.4	+	5	896	c.680C>T	c.(679-681)cCc>cTc	p.P227L	NT5M_ENST00000582909.1_3'UTR	NM_020201.3	NP_064586.1	Q9NPB1	NT5M_HUMAN	5',3'-nucleotidase, mitochondrial	227					DNA replication|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	5'-nucleotidase activity|metal ion binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4						AGCAAGCGGCCCTGCTGAGCT	0.682000													15	32					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81201555	81201555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81201555G>A	ENST00000394685.3	+	14	2124	c.1705G>A	c.(1705-1707)Gga>Aga	p.G569R	RP11-351M8.2_ENST00000560873.1_RNA|RP11-351M8.1_ENST00000560560.1_Intron|KIAA1199_ENST00000356249.5_Missense_Mutation_p.G569R|KIAA1199_ENST00000220244.3_Missense_Mutation_p.G569R			Q8WUJ3	K1199_HUMAN	KIAA1199	569										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						AGACGAAAGGGGAGGTTATGA	0.552000													23	77					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31441270	31441270	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:31441270G>A	ENST00000373747.3	-	11	1678	c.1579C>T	c.(1579-1581)Ccc>Tcc	p.P527S	PUM1_ENST00000257075.5_Missense_Mutation_p.P526S|PUM1_ENST00000373742.2_Missense_Mutation_p.P467S|PUM1_ENST00000373741.4_Missense_Mutation_p.P562S|PUM1_ENST00000423018.2_Missense_Mutation_p.P430S|PUM1_ENST00000424085.2_Missense_Mutation_p.P284S|PUM1_ENST00000490546.1_5'UTR|PUM1_ENST00000440538.2_Missense_Mutation_p.P527S|PUM1_ENST00000426105.2_Missense_Mutation_p.P526S	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	526	Ala-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		GCCACAAGGGGATCCGTTTGC	0.532000													22	60					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73567066	73567066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73567066C>T	ENST00000392550.3	+	17	2178	c.2061C>T	c.(2059-2061)ggC>ggT	p.G687G	LLGL2_ENST00000167462.5_Silent_p.G687G|LLGL2_ENST00000577200.1_Silent_p.G687G	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	687					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			AGCGGCCAGGCCTCCAGAACA	0.642000													33	92					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84070370	84070370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84070370G>A	ENST00000299709.3	-	2	324	c.325C>T	c.(325-327)Ctc>Ttc	p.L109F		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	109					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						AGGTTGAGGAGGAAGCAGGCC	0.632000													10	37					0	0	1	0	0
VCP	7415	broad.mit.edu	37	9	35060446	35060446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35060446G>A	ENST00000358901.6	-	13	2454	c.1559C>T	c.(1558-1560)cCt>cTt	p.P520L		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	520					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCCACAGCCAGGAGGTCCATA	0.498000													27	58					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124810341	124810341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124810341C>T	ENST00000423114.2	-	12	1949	c.1950G>A	c.(1948-1950)atG>atA	p.M650I	SLC12A8_ENST00000465475.1_Intron|SLC12A8_ENST00000314584.7_Intron|SLC12A8_ENST00000393469.4_Missense_Mutation_p.M621I|SLC12A8_ENST00000469902.1_Missense_Mutation_p.M621I|SLC12A8_ENST00000430155.2_Missense_Mutation_p.M422I			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	621					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						CAGCAACACCCATGTTAACCA	0.493000													12	59					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79343107	79343107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79343107C>T	ENST00000264895.6	+	34	5071	c.4631C>T	c.(4630-4632)cCc>cTc	p.P1544L	FRAS1_ENST00000325942.6_Missense_Mutation_p.P1544L	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1543					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TACCGCCCTCCCCCGGCAGCA	0.572000													61	144					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5687648	5687648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5687648G>A	ENST00000546188.1	-	22	2344	c.2273C>T	c.(2272-2274)tCc>tTc	p.S758F	ANO2_ENST00000356134.5_Missense_Mutation_p.S758F|ANO2_ENST00000327087.8_Missense_Mutation_p.S757F			Q9NQ90	ANO2_HUMAN	anoctamin 2	762						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CAGGGGAAAGGAGGCCACGAA	0.542000													4	24					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89521767	89521767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89521767G>A	ENST00000370473.4	-	8	1519	c.1300C>T	c.(1300-1302)Cgt>Tgt	p.R434C		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	434					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity	p.R434C(1)		endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		ACAAAGAGACGATAGCCCCCT	0.428000													121	342					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19752827	19752827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19752827G>A	ENST00000203556.4	-	3	275	c.138C>T	c.(136-138)ctC>ctT	p.L46L	GMIP_ENST00000587238.1_Silent_p.L46L|GMIP_ENST00000445806.2_Silent_p.L46L	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	46					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GGTCTTCTGAGAGTAGAGGGT	0.582000													10	25					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50220961	50220961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50220961C>T	ENST00000002829.3	+	12	1681	c.1197C>T	c.(1195-1197)ccC>ccT	p.P399P	SEMA3F_ENST00000413852.1_Silent_p.P300P|SEMA3F_ENST00000434342.1_Silent_p.P368P	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	399	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		AGTGGATGCCCTTCTCAGGGA	0.592000													31	69					0	0	1	0	0
LOC101927958	101927958	broad.mit.edu	37	2	239141527	239141527	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239141527C>T	ENST00000456601.1	+	0	906																											GGATCAGCATCCAATGCAGGG	0.502000													33	59					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6943094	6943094	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6943094C>T	ENST00000251761.8	+	0	1372				LEPREL2_ENST00000396725.2_RNA|LEPREL2_ENST00000538102.1_RNA|LEPREL2_ENST00000606935.1_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						GGCAGATGTCCTTCTCCTGGA	0.642000													21	79					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24583561	24583561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:24583561C>T	ENST00000358321.3	+	12	2175	c.1914C>T	c.(1912-1914)tcC>tcT	p.S638S		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	638	VWFD.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						ATGCGTCCTCCCTGCTCACCT	0.612000													20	67					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583817	82583817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82583817C>T	ENST00000423517.2	-	5	6789	c.6452G>A	c.(6451-6453)aGa>aAa	p.R2151K	PCLO_ENST00000333891.8_Missense_Mutation_p.R2151K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2082					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGAATTTCTCTTGTATAATC	0.413000													21	74					0	0	1	0	0
KLK1	3816	broad.mit.edu	37	19	51322476	51322476	+	Missense_Mutation	SNP	C	C	T	rs138173062		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51322476C>T	ENST00000448701.2	-	6	1781	c.457G>A	c.(457-459)Gag>Aag	p.E153K	KLK1_ENST00000301420.2_Missense_Mutation_p.E255K			P06870	KLK1_HUMAN	kallikrein 1	255	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity			breast(1)|large_intestine(4)|lung(7)|urinary_tract(1)	13		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATGGTGTCCTCGATCCACTTC	0.542000													15	96					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38397257	38397257	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:38397257G>A	ENST00000377698.3	+	2	1665	c.1512G>A	c.(1510-1512)gaG>gaA	p.E504E		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	504					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CCTACACAGAGGTAAAGACGG	0.532000													7	29					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92616111	92616111	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92616111C>T	ENST00000298047.6	+	23	12506	c.12489C>T	c.(12487-12489)ttC>ttT	p.F4163F	FAT3_ENST00000525166.1_Silent_p.F4013F|FAT3_ENST00000533797.1_Silent_p.F498F|FAT3_ENST00000409404.2_Silent_p.F4163F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4163					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGTCCTCTTCGTCATCTTCA	0.592000										TCGA Ovarian(4;0.039)			12	17					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208515	140208515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140208515C>T	ENST00000529310.1	+	1	953	c.839C>T	c.(838-840)tCt>tTt	p.S280F	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.S280F|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTCATATTCTTTTAATAGC	0.388000													69	144					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6180466	6180466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6180466G>A	ENST00000261405.5	-	10	1407	c.1153C>T	c.(1153-1155)Cca>Tca	p.P385S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	385					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CGCCTACCTGGACATTCTTCA	0.542000													16	35					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356406	40356406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40356406G>A	ENST00000310169.2	+	5	1448	c.1309G>A	c.(1309-1311)Gac>Aac	p.D437N		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	437					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	GTGCCTCAAAGACCACAAGGC	0.483000													12	111					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21689975	21689975	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:21689975C>T	ENST00000398485.2	+	4	1229	c.1175C>T	c.(1174-1176)cCg>cTg	p.P392L	PAX1_ENST00000444366.2_Missense_Mutation_p.P368L|PAX1_ENST00000460221.1_3'UTR	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	392					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						CCGGGCCCGCCGTGGCCGCCT	0.746000													31	10					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065523	35065523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35065523G>A	ENST00000382002.5	-	10	1963	c.1537C>T	c.(1537-1539)Cac>Tac	p.H513Y	PRLR_ENST00000511486.1_Missense_Mutation_p.H412Y|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.H412Y|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	513					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity	p.H513Y(1)		central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTGACCTTGTGAATCTCCACA	0.502000													46	90					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248039405	248039405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248039405G>A	ENST00000366481.3	+	6	1123	c.1075G>A	c.(1075-1077)Ggt>Agt	p.G359S	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	359	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGCAGAGTGGGGTTTAGGGGT	0.562000													30	66					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72368159	72368159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72368159C>T	ENST00000335666.4	+	4	857	c.809C>T	c.(808-810)tCg>tTg	p.S270L		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	270						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CGGGCCGCCTCGTCCCCAGGC	0.657000													7	30					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42853767	42853767	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42853767C>A	ENST00000334370.4	+	13	2849	c.2214C>A	c.(2212-2214)atC>atA	p.I738I	MEGF8_ENST00000251268.6_Silent_p.I805I	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	805						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CAGTAGAGATCCAGGGCCAGC	0.657000													5	53					2.0095e-06	2.01364e-06	1	1	0
COL6A2	1292	broad.mit.edu	37	21	47545985	47545985	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47545985C>A	ENST00000300527.4	+	26	2360	c.2256C>A	c.(2254-2256)gtC>gtA	p.V752V	COL6A2_ENST00000310645.5_Silent_p.V752V|COL6A2_ENST00000357838.4_Silent_p.V752V|COL6A2_ENST00000409416.1_Silent_p.V752V|COL6A2_ENST00000397763.1_Silent_p.V752V	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	752	Nonhelical region.|VWFA 2.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACCGCGACGTCACAGTGACGG	0.627000													57	153					9.59449e-18	9.64971e-18	1	1	0
FPR1	2357	broad.mit.edu	37	19	52250002	52250002	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52250002C>T	ENST00000595042.1	-	3	387	c.246G>A	c.(244-246)atG>atA	p.M82I	FPR1_ENST00000304748.4_Missense_Mutation_p.M82I	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	82					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CCTTCCTGACCATGAAGAATG	0.517000													15	91					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043328	117043328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117043328G>A	ENST00000371876.1	-	4	3570	c.1149C>T	c.(1147-1149)ttC>ttT	p.F383F	KLHL13_ENST00000262820.3_Silent_p.F434F|KLHL13_ENST00000371878.1_Silent_p.F383F|KLHL13_ENST00000371882.1_Silent_p.F383F|KLHL13_ENST00000541812.1_Silent_p.F418F|KLHL13_ENST00000545703.1_Silent_p.F392F|KLHL13_ENST00000469946.1_Silent_p.F383F|KLHL13_ENST00000539496.1_Silent_p.F437F|KLHL13_ENST00000540167.1_Silent_p.F418F			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	434					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CACTTAGGTGGAAGAAGGTGC	0.398000													18	16					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21328024	21328024	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21328024C>T	ENST00000313654.9	+	3	806	c.565_splice	c.e3+1	p.H189_splice	LAMA3_ENST00000399516.3_Splice_Site_p.H189_splice	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	189	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.H189N(2)		NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATATTTTGCTCGTAAGTAATC	0.373000													27	63					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94722800	94722800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94722800G>A	ENST00000304338.3	+	17	2023	c.1869G>A	c.(1867-1869)atG>atA	p.M623I		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	623						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						ATTGTAGAATGAAACTTTGCT	0.333000													16	25					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824694	54824694	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:54824694C>T	ENST00000243911.2	+	1	907	c.795C>T	c.(793-795)atC>atT	p.I265I		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	302					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			TGGTCCTCATCATCACCTGCC	0.562000													57	89					0	0	1	0	0
C17orf77	146723	broad.mit.edu	37	17	72588857	72588857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72588857C>T	ENST00000392620.1	+	3	1034	c.672C>T	c.(670-672)tcC>tcT	p.S224S	C17orf77_ENST00000328023.2_Silent_p.S224S	NM_152460.2	NP_689673.2	Q96MU5	CQ077_HUMAN	chromosome 17 open reading frame 77	224						extracellular region				breast(2)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11						TTGCCTCTTCCTGCCCTGGGC	0.572000													23	73					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3248121	3248121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3248121C>T	ENST00000217939.6	-	4	801	c.647G>A	c.(646-648)gGa>gAa	p.G216E		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	216						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCACGGATTTCCCTGCAAGTA	0.488000													5	9					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176948363	176948363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:176948363G>A	ENST00000308618.4	-	1	278	c.142C>T	c.(142-144)Cgc>Tgc	p.R48C		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	48						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GGGCTTAGGCGAGCCGGGTGC	0.607000													12	53					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152534253	152534253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152534253C>T	ENST00000427231.2	-	34	3802	c.3600G>A	c.(3598-3600)atG>atA	p.M1200I	NEB_ENST00000604864.1_Missense_Mutation_p.M1200I|NEB_ENST00000603639.1_Missense_Mutation_p.M1200I|NEB_ENST00000172853.10_Missense_Mutation_p.M1200I|NEB_ENST00000397345.3_Missense_Mutation_p.M1200I|NEB_ENST00000409198.1_Missense_Mutation_p.M1200I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1200					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAATGCCTTTCATCCAGTTGT	0.463000													88	268					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95109994	95109994	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95109994C>T	ENST00000469935.1	+	0	1031					NR_015340.1																						CTTCATCTTCCCCAACAGGGG	0.587000													11	26					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45392370	45392370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45392370C>T	ENST00000389039.6	-	24	3447	c.3062G>A	c.(3061-3063)cGa>cAa	p.R1021Q	DUOX2_ENST00000603300.1_Missense_Mutation_p.R1021Q			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1021	Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TAGGAAGCCTCGCTGCATCTT	0.597000													9	46					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96031005	96031005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96031005C>T	ENST00000297954.4	+	18	4010	c.4010C>T	c.(4009-4011)tCc>tTc	p.S1337F	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.S949F|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.S949F|WNK2_ENST00000395477.2_Missense_Mutation_p.S1337F			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1337					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CCTCTAAGCTCCCTGCCGCCA	0.627000													8	32					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42045551	42045551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42045551G>A	ENST00000372584.1	-	3	5932	c.4918C>T	c.(4918-4920)Ccg>Tcg	p.P1640S	HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1640S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1640S|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1640S|HIVEP3_ENST00000460604.1_5'UTR	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1640					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GAAACCCCCGGAAGGTTGGGG	0.493000													37	63					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35802491	35802491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35802491G>A	ENST00000400441.3	-	3	285	c.286C>T	c.(286-288)Ccc>Tcc	p.P96S	MROH8_ENST00000217333.8_Missense_Mutation_p.P11S|MROH8_ENST00000441008.2_Missense_Mutation_p.P82S					maestro heat-like repeat family member 8																		TAGGCACAGGGGATCACTACT	0.393000													9	26					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127253907	127253907	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127253907G>A	ENST00000341640.2	-	4	646	c.441C>T	c.(439-441)ccC>ccT	p.P147P	PAX4_ENST00000463946.1_Silent_p.P145P|PAX4_ENST00000378740.2_Silent_p.P147P|PAX4_ENST00000338516.3_Silent_p.P155P	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	155					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						AGCCACTATGGGGAGTGAGGA	0.562000													13	51					0	0	1	0	0
INTS4P2	644619	broad.mit.edu	37	7	65160108	65160108	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:65160108G>A	ENST00000430126.2	+	0	1278																											GACCCTCAGGGAGCCCAGGAG	0.507000													9	26					0	0	1	0	0
DDX42	11325	broad.mit.edu	37	17	61877952	61877952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61877952C>T	ENST00000578681.1	+	7	1197	c.596C>T	c.(595-597)cCt>cTt	p.P199L	DDX42_ENST00000583590.1_Missense_Mutation_p.P199L|DDX42_ENST00000359353.5_Missense_Mutation_p.P80L|DDX42_ENST00000457800.2_Missense_Mutation_p.P199L|DDX42_ENST00000389924.2_Missense_Mutation_p.P199L	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	199					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						ATCATTGATCCTCTTCCCCCC	0.388000													58	119					0	0	1	0	0
TSHR	7253	broad.mit.edu	37	14	81610660	81610660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81610660G>A	ENST00000541158.2	+	11	2580	c.2258G>A	c.(2257-2259)gGc>gAc	p.G753D	TSHR_ENST00000298171.2_Missense_Mutation_p.G753D|RP11-114N19.3_ENST00000557775.1_RNA			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	753					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	AAGAAGCAAGGCCAAATCTCA	0.403000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						34	99					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042515	74042515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74042515C>T	ENST00000409561.1	+	3	1286	c.1165C>T	c.(1165-1167)Cct>Tct	p.P389S		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	389										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TCCACTACTTCCTGTAGAAAT	0.423000													7	49					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65185747	65185747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:65185747G>A	ENST00000358691.5	-	11	988	c.822C>T	c.(820-822)acC>acT	p.T274T	HELZ_ENST00000580168.1_Silent_p.T274T	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GGGATTTTTTGGTGCTGACAG	0.353000													46	126					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55223733	55223733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55223733G>A	ENST00000340465.2	+	6	835	c.749G>A	c.(748-750)aGa>aAa	p.R250K		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	250						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CGTGTGACTAGAAAGTGCCAT	0.378000													31	73					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167626901	167626901	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167626901C>T	ENST00000519204.1	+	16	2950	c.2832C>T	c.(2830-2832)tcC>tcT	p.S944S	TENM2_ENST00000545108.1_Silent_p.S1065S|TENM2_ENST00000518659.1_Silent_p.S1065S|TENM2_ENST00000520394.1_Silent_p.S833S|TENM2_ENST00000403607.2_Silent_p.S889S					teneurin transmembrane protein 2																		TCCCTGGTTCCAATGTGAAAC	0.493000													16	193					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48133933	48133933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48133933C>T	ENST00000405493.2	-	23	2447	c.2238G>A	c.(2236-2238)gaG>gaA	p.E746E	RAPGEF3_ENST00000548919.1_Silent_p.E679E|RAPGEF3_ENST00000449771.2_Silent_p.E788E|RP1-197B17.3_ENST00000547799.1_lincRNA|RAPGEF3_ENST00000549151.1_Silent_p.E746E|RAPGEF3_ENST00000389212.3_Silent_p.E788E|RAPGEF3_ENST00000171000.4_Silent_p.E746E	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	746					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CCAGCAGCCTCTCGAGGGCGG	0.657000													3	15					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23827677	23827677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23827677C>T	ENST00000354639.3	+	21	2961	c.2497C>T	c.(2497-2499)Cat>Tat	p.H833Y	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Missense_Mutation_p.H856Y|STK31_ENST00000355870.3_Missense_Mutation_p.H856Y|STK31_ENST00000428484.1_Missense_Mutation_p.H833Y	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	856	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TGGATCACTTCATCAGAACAA	0.353000													47	82					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167184964	167184964	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167184964C>T	ENST00000476257.1	-	4	655	c.357G>A	c.(355-357)gtG>gtA	p.V119V	SERPINI2_ENST00000264677.4_Silent_p.V119V|SERPINI2_ENST00000471111.1_Silent_p.V119V|SERPINI2_ENST00000461846.1_Silent_p.V119V			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	119					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						ACTGTTCTTTCACAGTGAATC	0.368000													33	75					0	0	1	0	0
FLJ33360	401172	broad.mit.edu	37	5	6337369	6337369	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:6337369G>A	ENST00000507444.1	-	0	36					NR_028351.1																						GCTCACTTACGGCCCCCAGCA	0.537000													12	20					0	0	1	0	0
CASD1	64921	broad.mit.edu	37	7	94146881	94146881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94146881C>T	ENST00000297273.4	+	2	430	c.143C>T	c.(142-144)tCg>tTg	p.S48L		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	48						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			GGCAATGATTCGTGTGAATAC	0.338000													20	73					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175048623	175048623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175048623C>T	ENST00000239462.4	+	3	677	c.564C>T	c.(562-564)tgC>tgT	p.C188C		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	188	EGF-like 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCTGCCTGTGCCATGAGCCCT	0.746000													5	8					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90857667	90857667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:90857667C>T	ENST00000394980.1	+	7	3155	c.2836C>T	c.(2836-2838)Cct>Tct	p.P946S	MMRN1_ENST00000264790.2_Missense_Mutation_p.P946S|MMRN1_ENST00000508372.1_Missense_Mutation_p.P688S|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	946					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TGCTACCATCCCTAAGTGGAT	0.363000													21	60					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42540356	42540356	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42540356G>A	ENST00000358097.4	-	0	194				CYP2D7P1_ENST00000433992.1_RNA																endometrium(1)	1						CAGTGGCAGGGGACCTGGCGG	0.647000													8	14					0	0	1	0	0
OR10V1	390201	broad.mit.edu	37	11	59480873	59480873	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59480873G>A	ENST00000307552.2	-	1	464	c.446C>T	c.(445-447)tCc>tTc	p.S149F		NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						CAGCACCAAGGAGCCTACCAG	0.498000													13	29					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277282	114277282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114277282C>T	ENST00000357077.4	+	38	7561	c.7508C>T	c.(7507-7509)gCc>gTc	p.A2503V	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.A2470V|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2470					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACGGAAGTGGCCTCTGTGCGG	0.537000													24	108					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134627736	134627736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134627736G>A	ENST00000368586.5	-	54	7408	c.7308C>T	c.(7306-7308)atC>atT	p.I2436I	TTC40_ENST00000263170.5_Silent_p.I597I	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	597										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						TGTCTTGGGTGATGGAGACAG	0.562000													13	22					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135698623	135698623	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135698623G>A	ENST00000298545.3	-	9	1379	c.858C>T	c.(856-858)gcC>gcT	p.A286A	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	286	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						GGGCCAGGAGGGCGGCCTGCA	0.627000													61	104					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538849	55538849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55538849C>T	ENST00000220676.1	+	4	2555	c.2407C>T	c.(2407-2409)Cct>Tct	p.P803S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	803					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TAAAGTGTTTCCTCACAATGA	0.299000													20	43					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32053653	32053653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32053653G>A	ENST00000375244.3	-	7	3223	c.3022C>T	c.(3022-3024)Ctg>Ttg	p.L1008L	TNXB_ENST00000375247.2_Silent_p.L1008L			P22105	TENX_HUMAN	tenascin XB	1095	Fibronectin type-III 2.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCCCCTGGCAGCACTTCCTCA	0.677000													27	54					0	0	1	0	0
BATF2	116071	broad.mit.edu	37	11	64756878	64756878	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64756878G>A	ENST00000301887.4	-	3	678	c.548C>T	c.(547-549)tCc>tTc	p.S183F	BATF2_ENST00000527716.1_Missense_Mutation_p.S159F|BATF2_ENST00000435842.2_Missense_Mutation_p.S98F	NM_138456.3	NP_612465.3	Q8N1L9	BATF2_HUMAN	basic leucine zipper transcription factor, ATF-like 2	183						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|skin(1)	9						CTGCAGGCTGGAACCAGTGTG	0.657000													11	30					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16736518	16736518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16736518C>T	ENST00000335496.1	-	6	647	c.165G>A	c.(163-165)gaG>gaA	p.E55E	SPATA21_ENST00000466212.1_5'UTR|SPATA21_ENST00000540400.1_Silent_p.E32E	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	55							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		GCTCCCGCCTCTCTCCAATGT	0.652000													16	27					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21331581	21331581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21331581G>A	ENST00000256958.2	+	6	649	c.553G>A	c.(553-555)Gag>Aag	p.E185K		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	185					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TGGAATAGGGGAGACTCCCAT	0.348000													37	114					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53721836	53721836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:53721836G>A	ENST00000262135.4	-	5	664	c.571C>T	c.(571-573)Ccc>Tcc	p.P191S	RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.P191S|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.P191S|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.P191S	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	191					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				GTAAACATGGGATGTGGAGTT	0.308000													17	168					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150696629	150696629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150696629G>A	ENST00000335244.4	-	10	1330	c.1201C>T	c.(1201-1203)Ccc>Tcc	p.P401S	SLC36A2_ENST00000450886.1_Missense_Mutation_p.P125S	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	401					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCAGGCGGGGGATGAGGATG	0.582000													5	23					0	0	1	0	0
RAX	30062	broad.mit.edu	37	18	56939814	56939814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56939814C>T	ENST00000334889.3	-	2	508	c.322G>A	c.(322-324)Gag>Aag	p.E108K	RAX_ENST00000256852.7_Intron	NM_013435.2	NP_038463.2	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	108					visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E108K(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)		GGCCGTGCCTCCCCGGGCTCC	0.701000													17	57					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182392093	182392093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:182392093G>A	ENST00000397033.2	+	22	2839	c.2409G>A	c.(2407-2409)gaG>gaA	p.E803E		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	803					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GCATGGTGGAGAAAATGAACT	0.328000													23	62					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138163315	138163315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:138163315C>T	ENST00000409968.1	+	13	2811	c.2633C>T	c.(2632-2634)tCc>tTc	p.S878F	THSD7B_ENST00000272643.3_Missense_Mutation_p.S878F|THSD7B_ENST00000413152.2_Missense_Mutation_p.S847F|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ACTGCTTGGTCCAAGTTTACG	0.502000													8	22					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131792975	131792975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131792975G>A	ENST00000286355.5	-	18	5509	c.3417C>T	c.(3415-3417)atC>atT	p.I1139I	ADCY8_ENST00000377928.3_Silent_p.I1008I	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1139					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GGTCCTTCAGGATGAGATAGG	0.498000										HNSCC(32;0.087)			56	103					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294370	25294370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25294370G>A	ENST00000400358.4	+	19	2511	c.2454G>A	c.(2452-2454)agG>agA	p.R818R	SGSM1_ENST00000400359.4_Silent_p.R873R	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	873	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						AGGGCTGGAGGAGCAGCGAGA	0.592000													31	73					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887440	3887440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:3887440C>T	ENST00000319331.3	+	2	1876	c.1115C>T	c.(1114-1116)cCc>cTc	p.P372L	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	372	LRRCT.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CATAGCAATCCCCTCAGGTGT	0.488000													21	71					0	0	1	0	0
IL20RB	53833	broad.mit.edu	37	3	136728968	136728968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:136728968C>T	ENST00000329582.4	+	7	1088	c.839C>T	c.(838-840)tCa>tTa	p.S280L	IL20RB_ENST00000309741.5_3'UTR	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	280						integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						ATAACCAATTCACCCCAGAAG	0.378000													45	112					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234878920	234878920	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234878920C>T	ENST00000324695.4	+	17	2245	c.2205C>T	c.(2203-2205)ttC>ttT	p.F735F	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	735						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CCTCCCCCTTCGTGGTCTTCT	0.547000													111	232					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162280207	162280207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:162280207C>T	ENST00000389554.3	+	6	1835	c.1518C>T	c.(1516-1518)ttC>ttT	p.F506F	TBR1_ENST00000410035.1_Silent_p.F219F	NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	506						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						CCACGGACTTCGCGGGCAACG	0.731000													3	7					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386636	56386636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56386636G>A	ENST00000355701.3	-	22	4867	c.3997C>T	c.(3997-3999)Ccg>Tcg	p.P1333S	BZRAP1_ENST00000268893.6_Missense_Mutation_p.P1273S|BZRAP1_ENST00000343736.4_Missense_Mutation_p.P1333S	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1333						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tcctcctccGGGATGCTAAAG	0.597000													16	46					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31159911	31159911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31159911G>A	ENST00000268281.4	-	5	416	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C	PRSS36_ENST00000569305.1_Missense_Mutation_p.R120C|PRSS36_ENST00000418068.2_Missense_Mutation_p.R120C	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	120	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						GCCACTGCGCGGGTGTGCGCG	0.751000													16	34					0	0	1	0	0
TRAV8-1	28685	broad.mit.edu	37	14	22265871	22265871	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22265871C>T	ENST00000390430.2	+	0	286																											AACTGTTAATCTCTTCTGGTA	0.493000													11	118					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49932749	49932749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49932749G>A	ENST00000296474.3	-	14	3149	c.3122C>T	c.(3121-3123)tCc>tTc	p.S1041F	MST1R_ENST00000344206.4_Missense_Mutation_p.S992F	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	1041					cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TTCACTATCGGAGAAGGATGC	0.562000													45	108					0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53912393	53912393	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53912393G>A	ENST00000335754.3	-	3	496	c.396C>T	c.(394-396)tcC>tcT	p.S132S	ACTR8_ENST00000482349.1_Silent_p.S21S	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	132					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		CCTGTTCAGGGGACACAGGAA	0.363000													42	193					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62327271	62327271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62327271G>A	ENST00000371158.2	+	19	2485	c.2371G>A	c.(2371-2373)Gaa>Aaa	p.E791K	INADL_ENST00000316485.6_Missense_Mutation_p.E791K	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	791					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						AAGCAGTAATGAAGACAAGAC	0.274000													57	133					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	137028077	137028077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:137028077G>A	ENST00000541417.1	-	3	610	c.68C>T	c.(67-69)aCt>aTt	p.T23I	KLHL3_ENST00000506491.1_Silent_p.D59D|KLHL3_ENST00000394937.3_Silent_p.D141D|KLHL3_ENST00000309755.4_Silent_p.D141D|KLHL3_ENST00000508657.1_Silent_p.D109D			Q9UH77	KLHL3_HUMAN	kelch-like family member 3	0						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		ACTGCAGGAAGTCACAGCAGT	0.552000													7	33					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61745770	61745770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:61745770G>A	ENST00000325324.6	+	4	425	c.256G>A	c.(256-258)Gag>Aag	p.E86K	KIF2A_ENST00000509663.2_Intron|IPO11_ENST00000409296.3_Missense_Mutation_p.E126K	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	86	Importin N-terminal.					cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		CTCAGAGGAGGAGAAAACTAC	0.328000													25	78					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46801051	46801051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46801051C>T	ENST00000230588.4	+	11	1394	c.1385C>T	c.(1384-1386)tCg>tTg	p.S462L		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	462	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding	p.S462*(1)		NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			TTCTACAATTCGGAGGGATAT	0.502000													7	98					0	0	1	0	0
ALG8	79053	broad.mit.edu	37	11	77812146	77812146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:77812146G>A	ENST00000299626.5	-	13	1516	c.1445C>T	c.(1444-1446)tCc>tTc	p.S482F	ALG8_ENST00000376156.3_3'UTR	NM_024079.4	NP_076984.2	Q9BVK2	ALG8_HUMAN	ALG8, alpha-1,3-glucosyltransferase	482					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	30	all_cancers(14;3.62e-19)|all_epithelial(13;1.27e-21)|Breast(9;8.51e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;9.66e-25)			CACCTTCCAGGAGGTGAAAGG	0.423000													28	89					0	0	1	0	0
SPC25	57405	broad.mit.edu	37	2	169730139	169730139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169730139G>A	ENST00000282074.2	-	6	647	c.506C>T	c.(505-507)cCa>cTa	p.P169L		NM_020675.3	NP_065726.1	Q9HBM1	SPC25_HUMAN	SPC25, NDC80 kinetochore complex component	169	Interaction with the C-terminus of SPBC24.				cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	9						AAACATAAATGGGCTCTCAGG	0.338000													29	153					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018713	62018713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62018713G>A	ENST00000578147.1	-	24	5005	c.4929C>T	c.(4927-4929)ttC>ttT	p.F1643F	SCN4A_ENST00000435607.1_Silent_p.F1643F			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1643					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GGGTGTCCACGAAGTCTGAGA	0.567000													19	62					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179604914	179604914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179604914C>T	ENST00000444136.1	+	9	1662	c.1412C>T	c.(1411-1413)tCc>tTc	p.S471F	TDRD5_ENST00000367614.1_Missense_Mutation_p.S471F|TDRD5_ENST00000294848.8_Missense_Mutation_p.S471F	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	471					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GACACCAGTTCCCTCATAGGG	0.453000													21	70					0	0	1	0	0
RNF8	9025	broad.mit.edu	37	6	37328278	37328278	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:37328278C>T	ENST00000373479.4	+	2	361	c.168C>T	c.(166-168)ccC>ccT	p.P56P	RNF8_ENST00000479516.1_3'UTR|RNF8_ENST00000394443.4_Silent_p.P56P|RNF8_ENST00000469731.1_Silent_p.P56P	NM_003958.3|NM_183078.2	NP_003949.1|NP_898901.1	O76064	RNF8_HUMAN	ring finger protein 8, E3 ubiquitin protein ligase	56	FHA.				cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	13						AAATCTGCCCCCTGATGATTT	0.443000													25	82					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7712089	7712089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7712089C>T	ENST00000441779.2	+	17	1564	c.1527C>T	c.(1525-1527)ttC>ttT	p.F509F	STXBP2_ENST00000221283.5_Silent_p.F498F|STXBP2_ENST00000602355.1_Silent_p.F33F|STXBP2_ENST00000414284.2_Silent_p.F495F	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	498					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						TGTGGCCCTTCGTATCCGACC	0.736000													20	54					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25684939	25684939	+	Missense_Mutation	SNP	C	C	T	rs141199449		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25684939C>T	ENST00000376351.3	+	3	1467	c.1108C>T	c.(1108-1110)Cgg>Tgg	p.R370W		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	370						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GAACAACTTTCGGAGTAAGTG	0.358000													12	35					0	0	1	0	0
STK38	11329	broad.mit.edu	37	6	36492232	36492232	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36492232G>A	ENST00000229812.7	-	4	477	c.192C>T	c.(190-192)ctC>ctT	p.L64L		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	64	Interaction with S100B.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTGATCTCCGGAGTCGTTTCT	0.393000													28	72					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170965663	170965663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:170965663C>T	ENST00000367759.4	+	14	1507	c.1353C>T	c.(1351-1353)gcC>gcT	p.A451A	MROH9_ENST00000367758.3_Silent_p.A451A	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		CCCAGGATGCCCTGAGAGTTC	0.418000													30	86					0	0	1	0	0
MEIS1	4211	broad.mit.edu	37	2	66795861	66795861	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:66795861C>T	ENST00000488550.1	+	11	1386	c.1087C>T	c.(1087-1089)Cag>Tag	p.Q363*	MEIS1_ENST00000398506.2_Nonsense_Mutation_p.Q361*|MEIS1_ENST00000495021.2_Nonsense_Mutation_p.Q298*|MEIS1_ENST00000272369.9_Nonsense_Mutation_p.Q363*|MEIS1_ENST00000444274.2_3'UTR|MEIS1_ENST00000409517.1_3'UTR|MEIS1_ENST00000407092.2_Nonsense_Mutation_p.Q363*			O00470	MEIS1_HUMAN	Meis homeobox 1	363	Required for transcriptional activation (By similarity).						sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						AATGGACGGTCAGCAACATAT	0.408000													52	199					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56094424	56094424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56094424C>T	ENST00000426658.2	-	3	1425	c.764G>A	c.(763-765)gGa>gAa	p.G255E	CTCFL_ENST00000422869.2_Missense_Mutation_p.G255E|CTCFL_ENST00000422109.2_Missense_Mutation_p.G255E|CTCFL_ENST00000433949.2_Missense_Mutation_p.G255E|CTCFL_ENST00000502686.2_5'UTR|CTCFL_ENST00000371196.2_Missense_Mutation_p.G255E|CTCFL_ENST00000423479.2_Missense_Mutation_p.G255E|CTCFL_ENST00000539382.1_Missense_Mutation_p.G50E|CTCFL_ENST00000481655.1_5'UTR|CTCFL_ENST00000243914.3_Missense_Mutation_p.G255E|CTCFL_ENST00000429804.2_Missense_Mutation_p.G255E|CTCFL_ENST00000432255.2_Missense_Mutation_p.G255E			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	255					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GTGGAAGGTTCCTTTTGCTCC	0.378000													63	137					0	0	1	0	0
ASB17	127247	broad.mit.edu	37	1	76397607	76397607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:76397607C>T	ENST00000284142.6	-	1	509	c.370G>A	c.(370-372)Gac>Aac	p.D124N		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	124					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						CAACTTCTGTCTTGAACATAG	0.338000													6	47					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87724972	87724972	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:87724972G>A	ENST00000436978.1	+	43	7111	c.6631G>A	c.(6631-6633)Ggt>Agt	p.G2211S	PTPN13_ENST00000511467.1_Missense_Mutation_p.G2211S|PTPN13_ENST00000427191.2_Missense_Mutation_p.G2187S|PTPN13_ENST00000316707.6_Missense_Mutation_p.G2015S|PTPN13_ENST00000411767.2_Missense_Mutation_p.G2206S	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2206						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AGTCCTGCGGGGTTTGCTAGA	0.458000													12	158					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128150761	128150761	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:128150761C>T	ENST00000368250.1	-	4	830	c.332G>A	c.(331-333)tGg>tAg	p.W111*	THEMIS_ENST00000368248.2_Nonsense_Mutation_p.W190*|THEMIS_ENST00000543064.1_Nonsense_Mutation_p.W190*|THEMIS_ENST00000537166.1_Nonsense_Mutation_p.W155*			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	190	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						AGGAATCTTCCATTCAACAAT	0.353000													33	48					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38775563	38775563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:38775563G>A	ENST00000308973.4	-	4	2254	c.1649C>T	c.(1648-1650)tCa>tTa	p.S550L	TLR10_ENST00000508334.1_Missense_Mutation_p.S550L|TLR10_ENST00000361424.2_Missense_Mutation_p.S550L|TLR10_ENST00000506111.1_Missense_Mutation_p.S550L	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	550	LRRCT.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						ACAGGTGTATGAATCTGACCA	0.393000													32	98					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19375254	19375254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19375254G>A	ENST00000263208.5	-	11	1349	c.1093C>T	c.(1093-1095)Ccc>Tcc	p.P365S	HIRA_ENST00000541063.1_Missense_Mutation_p.P321S|HIRA_ENST00000546308.1_Missense_Mutation_p.P321S|HIRA_ENST00000340170.4_Missense_Mutation_p.P365S	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	365					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					TCGCTCAGGGGATCGCCAAGC	0.572000													9	23					0	0	1	0	0
DUPD1	338599	broad.mit.edu	37	10	76797674	76797674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76797674C>T	ENST00000338487.5	-	3	582	c.583G>A	c.(583-585)Gag>Aag	p.E195K		NM_001003892.1	NP_001003892.1	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase domain containing 1	195	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TTGTCCAGCTCCCGGAGCTGC	0.647000													36	56					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197183412	197183412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197183412C>T	ENST00000260983.2	-	9	2384	c.2202G>A	c.(2200-2202)ggG>ggA	p.G734G	HECW2_ENST00000409111.1_Silent_p.G378G	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	734					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						GCCAGACCTCCCCCAGCTCCT	0.652000													14	32					0	0	1	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382208	41382208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41382208C>T	ENST00000377801.3	-	2	606	c.532G>A	c.(532-534)Gaa>Aaa	p.E178K	PLCXD3_ENST00000328457.3_Missense_Mutation_p.E178K			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	178	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						AAACTAACTTCCTGGGCAAAA	0.448000													17	180					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158637664	158637664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158637664C>T	ENST00000368148.3	-	15	2202	c.2022G>A	c.(2020-2022)gaG>gaA	p.E674E	SPTA1_ENST00000368147.3_Silent_p.E674E	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	674					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTTTGTAGCCTCCAGCAACT	0.423000													20	51					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11364993	11364993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:11364993C>T	ENST00000304623.8	-	8	1376	c.1187G>A	c.(1186-1188)cGa>cAa	p.R396Q	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.R59Q|CTNND2_ENST00000511377.1_Missense_Mutation_p.R305Q|CTNND2_ENST00000458100.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.R396Q	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	396					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GTATGAGGCTCGGGAACCAGC	0.488000													10	41					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116975543	116975543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116975543G>A	ENST00000355044.3	+	9	1563	c.1437G>A	c.(1435-1437)aaG>aaA	p.K479K		NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	479						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAATAACAAAGTCCATTTATG	0.363000													25	62					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9864270	9864270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:9864270C>T	ENST00000380913.3	+	4	2412	c.2322C>T	c.(2320-2322)ctC>ctT	p.L774L		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	774					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				AGGTGGGCCTCACGAGGGGCT	0.587000													15	8					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179525581	179525581	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:179525581C>T	ENST00000467460.1	-	14	1887	c.1557G>A	c.(1555-1557)gcG>gcA	p.A519A	PEX5L_ENST00000472994.1_Silent_p.A460A|PEX5L_ENST00000468741.1_Silent_p.A327A|PEX5L_ENST00000465751.1_Silent_p.A495A|PEX5L_ENST00000464614.1_Silent_p.A411A|PEX5L_ENST00000392649.3_Silent_p.A411A|PEX5L_ENST00000263962.8_Silent_p.A517A|PEX5L_ENST00000485199.1_Silent_p.A484A|PEX5L_ENST00000476138.1_Silent_p.A476A|PEX5L_ENST00000467440.2_5'UTR	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	519					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GGTCTCCGTTCGCCAAGGTCG	0.527000													14	202					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13936915	13936915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:13936915C>T	ENST00000294489.6	+	3	804	c.463C>T	c.(463-465)Cgc>Tgc	p.R155C	PDPN_ENST00000487038.1_Missense_Mutation_p.R37C|PDPN_ENST00000513143.1_Missense_Mutation_p.R37C|PDPN_ENST00000475043.1_Missense_Mutation_p.R37C|PDPN_ENST00000376061.4_Missense_Mutation_p.R37C|PDPN_ENST00000509009.1_Missense_Mutation_p.R74C|PDPN_ENST00000376057.4_Missense_Mutation_p.R155C			Q86YL7	PDPN_HUMAN	podoplanin	79					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		AACAGGCATTCGCATCGAGGA	0.478000													36	93					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47921602	47921602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47921602G>A	ENST00000289672.2	-	20	3397	c.3347C>T	c.(3346-3348)cCc>cTc	p.P1116L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1116	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AGACAGGGAGGGGTCCACCAG	0.567000													23	62					0	0	1	0	0
LOC642943	642943	broad.mit.edu	37	9	95646896	95646896	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95646896C>T	ENST00000446878.1	+	0	430				ANKRD19P_ENST00000473204.1_RNA																							GACCTGCTTTCACAACTGCAG	0.607000													44	125					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137712030	137712030	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137712030C>T	ENST00000371817.3	+	58	4929	c.4515C>T	c.(4513-4515)ctC>ctT	p.L1505L		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1505	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ACCGTGGTCTCCCTGGCCCCC	0.602000													20	53					0	0	1	0	0
APOA2	336	broad.mit.edu	37	1	161193180	161193180	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161193180G>A	ENST00000367990.3	-	2	69	c.12C>T	c.(10-12)ctC>ctT	p.L4L	APOA2_ENST00000481413.1_5'UTR	NM_001643.1	NP_001634.1	P02652	APOA2_HUMAN	apolipoprotein A-II	4					cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(2)|skin(2)	6	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAGTTGCTGCGAGCAGCTTCA	0.572000													7	24					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159166008	159166008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:159166008C>T	ENST00000283233.5	-	9	1360	c.1047G>A	c.(1045-1047)atG>atA	p.M349I	CCDC148_ENST00000536771.1_Missense_Mutation_p.M263I|CCDC148_ENST00000409187.1_Missense_Mutation_p.M358I	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	349										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						ACATGCTCTCCATTTCATGTG	0.403000													9	77					0	0	1	0	0
POLR1C	9533	broad.mit.edu	37	6	43484866	43484866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43484866G>A	ENST00000372389.3	+	1	107	c.19G>A	c.(19-21)Gtg>Atg	p.V7M	POLR1C_ENST00000372344.2_Missense_Mutation_p.V7M|POLR1C_ENST00000304004.3_Missense_Mutation_p.V7M	NM_203290.2	NP_976035.1	O15160	RPAC1_HUMAN	polymerase (RNA) I polypeptide C, 30kDa	7					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			TTCTCAGGCGGTGGAGGAAAT	0.612000													30	98					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41165464	41165464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41165464C>T	ENST00000380588.4	+	8	1155	c.1052C>T	c.(1051-1053)aCc>aTc	p.T351I		NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	351						integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				GTTGCAGACACCGCTTCTCTC	0.418000													35	114					0	0	1	0	0
BACE2	25825	broad.mit.edu	37	21	42647492	42647492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:42647492C>T	ENST00000330333.6	+	9	1961	c.1498C>T	c.(1498-1500)Ccc>Tcc	p.P500S	BACE2_ENST00000466122.1_3'UTR|BACE2_ENST00000328735.6_3'UTR|BACE2_ENST00000347667.4_Missense_Mutation_p.P450S	NM_012105.3	NP_036237.2	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2	500					membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				TCAGCGTCGCCCCCGTGACCC	0.542000													9	47					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160604751	160604751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160604751C>T	ENST00000259050.3	+	5	1072	c.950C>T	c.(949-951)tCt>tTt	p.S317F	MARCH7_ENST00000409591.1_Missense_Mutation_p.S279F|MARCH7_ENST00000409175.1_Missense_Mutation_p.S317F|MARCH7_ENST00000539065.1_Missense_Mutation_p.S261F	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	317	Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						TCTTACGTTTCTCCAAGAATC	0.393000													29	45					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64639846	64639846	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:64639846C>T	ENST00000587624.1	+	0	729																											CCGAGAAGATCAGCTTGACAC	0.453000													18	64					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173942648	173942648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:173942648G>A	ENST00000506823.1	+	12	2167	c.1510G>A	c.(1510-1512)Gaa>Aaa	p.E504K	GALNTL6_ENST00000508122.1_Missense_Mutation_p.E487K	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	504	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.?(1)		breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						TGGATGGAGAGAAGATATTCG	0.478000													27	121					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12211262	12211262	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:12211262G>A	ENST00000432424.2	+	0	1336							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						ACCAGGTCATGGACTGTAGCA	0.512000													14	38					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108754254	108754254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108754254C>T	ENST00000232603.5	-	15	1474	c.1392G>A	c.(1390-1392)gaG>gaA	p.E464E	MORC1_ENST00000483760.1_Silent_p.E464E	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	464					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTAAAGGTTTCTCCACATCGA	0.299000													8	54					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102826412	102826412	+	Missense_Mutation	SNP	G	G	A	rs2276093	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102826412G>A	ENST00000260302.3	-	1	51	c.23C>T	c.(22-24)gCc>gTc	p.A8V	MMP13_ENST00000340273.4_Missense_Mutation_p.A8V	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	8					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GAAGAGGAAGGCAGCCAGGAC	0.517000													19	75					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921215	24921215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24921215C>T	ENST00000329468.2	+	1	675	c.201C>T	c.(199-201)gcC>gcT	p.A67A		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TCTTCGTCGCCCCTAAGAGGC	0.716000													8	35					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85448657	85448657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:85448657G>A	ENST00000316356.4	-	5	996	c.432C>T	c.(430-432)tcC>tcT	p.S144S	SYTL2_ENST00000524452.1_Silent_p.S144S|SYTL2_ENST00000528231.1_Silent_p.S144S|SYTL2_ENST00000527523.1_Silent_p.S96S|SYTL2_ENST00000389960.4_Silent_p.S144S			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	144					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGTTTTCCTGGGACATATCAA	0.373000													10	49					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54604082	54604082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54604082C>T	ENST00000474759.1	+	8	887	c.839C>T	c.(838-840)tCa>tTa	p.S280L	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.S186L|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.S280L|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.S280L	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	280	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CAAACAGTCTCATCCATTTTG	0.448000													54	117					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15831419	15831419	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:15831419C>T	ENST00000338282.6	-	25	3286	c.3180G>A	c.(3178-3180)ctG>ctA	p.L1060L	MYH11_ENST00000576790.1_Silent_p.L1060L|MYH11_ENST00000396324.3_Silent_p.L1067L|MYH11_ENST00000452625.2_Silent_p.L1067L|MYH11_ENST00000300036.5_Silent_p.L1060L	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1060					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CATCACCCTCCAGCTTCCGTT	0.587000			T	CBFB	AML								22	75					0	0	1	0	0
TBC1D8	11138	broad.mit.edu	37	2	101656712	101656712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:101656712G>A	ENST00000409318.1	-	6	1138	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	TBC1D8_ENST00000376840.4_Silent_p.F321F	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	321	GRAM 2.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						TGTCAGAGGCGAACATCCGCC	0.582000													22	47					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128482972	128482972	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128482972G>A	ENST00000325888.8	+	16	2775	c.2514G>A	c.(2512-2514)gcG>gcA	p.A838A	FLNC_ENST00000346177.6_Silent_p.A838A	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	838					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CACCAGGGGCGGGCCGCTACA	0.592000													5	47					0	0	1	0	0
MSRB3	253827	broad.mit.edu	37	12	65847522	65847522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:65847522C>T	ENST00000308259.5	+	6	581	c.307C>T	c.(307-309)Cac>Tac	p.H103Y	MSRB3_ENST00000355192.3_Missense_Mutation_p.H110Y|MSRB3_ENST00000535664.1_Missense_Mutation_p.H103Y|MSRB3_ENST00000540804.1_Missense_Mutation_p.H110Y	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	110					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		GCCTTCATTCCACGATGTGAT	0.448000													27	58					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133948017	133948017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133948017G>A	ENST00000220616.4	+	25	4989	c.4949G>A	c.(4948-4950)gGg>gAg	p.G1650E	TG_ENST00000542445.1_Missense_Mutation_p.G84E|TG_ENST00000377869.1_Missense_Mutation_p.G1593E	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1650					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GATGCACTGGGGAACTCAAAG	0.448000													15	43					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42474456	42474456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42474456G>A	ENST00000545399.1	-	18	2615	c.2462C>T	c.(2461-2463)cCt>cTt	p.P821L	ATP1A3_ENST00000302102.5_Missense_Mutation_p.P808L|ATP1A3_ENST00000602133.1_Missense_Mutation_p.P778L|ATP1A3_ENST00000543770.1_Missense_Mutation_p.P819L	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	808					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						TGAGATGGCAGGGACCTAGGC	0.632000													15	36					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841951	94841951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94841951G>A	ENST00000357742.4	+	1	457	c.457G>A	c.(457-459)Gag>Aag	p.E153K	MCTP2_ENST00000543482.1_Missense_Mutation_p.E153K|MCTP2_ENST00000451018.3_Missense_Mutation_p.E153K|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	153					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TGCACCAGAAGAGCCAGAGGT	0.532000													29	101					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230456417	230456417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:230456417G>A	ENST00000341772.4	-	2	598	c.464C>T	c.(463-465)cCt>cTt	p.P155L		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	155					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AGCAGGAACAGGCTGAAGCTG	0.552000													5	69					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117681165	117681165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117681165G>A	ENST00000317775.6	-	19	3584	c.2899C>T	c.(2899-2901)Cgc>Tgc	p.R967C	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.R1001C	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	967					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTCCAGCTGCGATCATTGCTG	0.512000													24	72					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37262227	37262227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37262227C>T	ENST00000310758.4	-	10	1420	c.773G>A	c.(772-774)aGg>aAg	p.R258K	ELMO1_ENST00000448602.1_Missense_Mutation_p.R258K|ELMO1_ENST00000442504.1_Missense_Mutation_p.R258K	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	258					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TACCTGCCTCCTCTCATCAGG	0.428000													19	79					0	0	1	0	0
SAMSN1	64092	broad.mit.edu	37	21	15893541	15893541	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:15893541C>T	ENST00000285670.2	-	3	437	c.261_splice	c.e3-1	p.R88_splice	SAMSN1_ENST00000400564.1_Intron|SAMSN1_ENST00000400566.1_Splice_Site_p.R20_splice	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	20					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		ACTGCTGCTTCGCTATAAAAT	0.303000													11	21					0	0	1	0	0
ZNF367	195828	broad.mit.edu	37	9	99160471	99160471	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:99160471G>A	ENST00000375256.4	-	2	842	c.546C>T	c.(544-546)ctC>ctT	p.L182L		NM_153695.3	NP_710162.1	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	182					regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(4)|large_intestine(3)|lung(3)|prostate(1)	12		Acute lymphoblastic leukemia(62;0.0167)				TGTGAGCCTGGAGCGATTTCT	0.358000													59	206					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046641	42046641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42046641G>A	ENST00000372584.1	-	3	4842	c.3828C>T	c.(3826-3828)tcC>tcT	p.S1276S	HIVEP3_ENST00000429157.2_Silent_p.S1276S|HIVEP3_ENST00000372583.1_Silent_p.S1276S|HIVEP3_ENST00000247584.5_Silent_p.S1276S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1276					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTGTGCTGGGGGAGAGGCCAG	0.612000													5	50					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7707367	7707367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7707367G>A	ENST00000441779.2	+	10	917	c.880G>A	c.(880-882)Gag>Aag	p.E294K	STXBP2_ENST00000221283.5_Missense_Mutation_p.E283K|STXBP2_ENST00000414284.2_Missense_Mutation_p.E280K	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	283					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						CTTGCTGGACGAGGACGATGA	0.662000													56	143					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141290858	141290858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:141290858G>A	ENST00000247452.3	-	3	1263	c.916C>T	c.(916-918)Cat>Tat	p.H306Y		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	306	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					CTTTCTGAATGGGCTCTCGGA	0.468000										HNSCC(46;0.14)			39	39					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14306614	14306614	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:14306614G>A	ENST00000378053.3	-	2	1795	c.1539C>T	c.(1537-1539)ctC>ctT	p.L513L	FLRT3_ENST00000341420.4_Silent_p.L513L|MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	513					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GCTCTCGATTGAGGGTGGTTG	0.468000													23	120					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39046462	39046462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:39046462C>T	ENST00000518318.2	+	1	55	c.13C>T	c.(13-15)Ctt>Ttt	p.L5F	POU6F2_ENST00000403058.1_Missense_Mutation_p.L5F|POU6F2-AS2_ENST00000420243.1_RNA			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	5					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						GAGTGCTCTTCTTCAGGTATT	0.348000													15	104					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53298740	53298740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53298740G>A	ENST00000552551.1	-	2	458	c.26C>T	c.(25-27)tCc>tTc	p.S9F	KRT8_ENST00000546897.1_Missense_Mutation_p.S9F|KRT8_ENST00000293308.6_Missense_Mutation_p.S9F|KRT8_ENST00000552150.1_Missense_Mutation_p.S37F			P05787	K2C8_HUMAN	keratin 8	9	Head.|Ser-rich.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTTGTAGGACTTCTGGGT	0.647000													10	17					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105367139	105367139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:105367139C>T	ENST00000297581.2	+	3	1113	c.1064C>T	c.(1063-1065)tCc>tTc	p.S355F	DCSTAMP_ENST00000517991.1_Intron|DPYS_ENST00000521601.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	355					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											CATGATTCTTCCTTTAATATA	0.333000													16	44					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44671797	44671797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44671797C>T	ENST00000454036.1	+	9	1217	c.1141C>T	c.(1141-1143)Ctc>Ttc	p.L381F	SLC12A5_ENST00000243964.3_Missense_Mutation_p.L358F|SLC12A5_ENST00000539566.1_Intron	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	381					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity	p.L358I(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CACAGAGAACCTCTGGAGCTC	0.607000													76	162					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803392	23803392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:23803392C>T	ENST00000264867.2	-	12	2373	c.2254G>A	c.(2254-2256)Gga>Aga	p.G752R	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	752	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TGCTTGCGTCCACAAAAGTAC	0.398000													8	49					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645491	45645491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:45645491C>T	ENST00000303230.4	-	2	702	c.645G>A	c.(643-645)atG>atA	p.M215I		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	215						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TTAAATAATTCATCTTGATCA	0.368000													16	59					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1260591	1260591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1260591C>T	ENST00000348261.5	+	20	4226	c.3978C>T	c.(3976-3978)gtC>gtT	p.V1326V	CACNA1H_ENST00000565831.1_Silent_p.V1326V|CACNA1H_ENST00000358590.4_Silent_p.V1326V	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1326					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGGAGCGGGTCTTCCTCAGCG	0.667000													7	28					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174291	150174291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150174291C>T	ENST00000307271.3	+	5	1995	c.1421C>T	c.(1420-1422)aCc>aTc	p.T474I		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	474						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAGCCAGTCACCAAGACCAGC	0.602000													22	43					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34051053	34051053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:34051053G>A	ENST00000382499.2	-	12	1528	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F	SYNJ1_ENST00000357345.3_Missense_Mutation_p.S471F|SYNJ1_ENST00000382491.3_Missense_Mutation_p.S474F|SYNJ1_ENST00000322229.7_Missense_Mutation_p.S471F|SYNJ1_ENST00000433931.2_Missense_Mutation_p.S510F	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	471	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						CTCTTGCTTGGAGCTGTCAAA	0.408000													21	94					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3811344	3811344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3811344C>T	ENST00000262961.4	-	15	2273	c.2263G>A	c.(2263-2265)Gat>Aat	p.D755N		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	755						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		TCACCTGCATCAGCCTGAGGC	0.642000													4	7					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178562985	178562985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178562985C>T	ENST00000251582.7	-	13	2111	c.2010G>A	c.(2008-2010)atG>atA	p.M670I		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	670	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCATGCGCTTCATGGACACCA	0.647000													8	106					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111060798	111060798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111060798G>A	ENST00000369771.2	-	1	999	c.612C>T	c.(610-612)ctC>ctT	p.L204L		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	204						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		ACTCAAAGAGGAGCCAGAACT	0.557000													20	56					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31538324	31538324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31538324C>T	ENST00000261592.5	-	7	1412	c.1115G>A	c.(1114-1116)gGa>gAa	p.G372E	NOL4_ENST00000535475.1_Missense_Mutation_p.G217E|NOL4_ENST00000269185.4_Missense_Mutation_p.G258E|NOL4_ENST00000535384.1_Missense_Mutation_p.G87E|NOL4_ENST00000538587.1_Missense_Mutation_p.G298E|NOL4_ENST00000589544.1_Missense_Mutation_p.G372E	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	372						nucleolus	RNA binding	p.G372A(1)		NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						GTCCTCAGCTCCTCGGTCTAC	0.463000													34	204					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151105853	151105853	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151105853G>A	ENST00000341697.3	-	19	3591	c.1900C>T	c.(1900-1902)Cga>Tga	p.R634*				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	634						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCCGACGTCGGTGGGCGCGG	0.726000													7	15					0	0	1	0	0
ADAMTSL2	9719	broad.mit.edu	37	9	136401900	136401900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136401900G>A	ENST00000393061.3	+	2	825	c.393G>A	c.(391-393)ggG>ggA	p.G131G	ADAMTSL2_ENST00000354484.4_Silent_p.G22G|ADAMTSL2_ENST00000393060.1_Silent_p.G22G			Q86TH1	ATL2_HUMAN	ADAMTS-like 2	22					negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(145;9.31e-08)|Epithelial(140;6.62e-07)|all cancers(34;7.74e-06)		TTGTAGCTGGGGACACAGTGT	0.602000													17	64					0	0	1	0	0
IFI27	3429	broad.mit.edu	37	14	94578120	94578120	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94578120G>A	ENST00000555744.1	+	2	279		c.e2+1		IFI27_ENST00000298902.5_Splice_Site|IFI27_ENST00000448882.1_Splice_Site|IFI27_ENST00000557098.1_Intron|IFI27_ENST00000557634.1_Splice_Site|IFI27_ENST00000444961.1_Splice_Site			P40305	IFI27_HUMAN	interferon, alpha-inducible protein 27						activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion				breast(1)|lung(3)	4				Epithelial(152;0.112)|all cancers(159;0.187)|COAD - Colon adenocarcinoma(157;0.206)		TTGCCCCTGGGTGAGTGTTCC	0.667000													14	48					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117504152	117504152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:117504152C>T	ENST00000393203.2	+	5	1648	c.1501C>T	c.(1501-1503)Cgg>Tgg	p.R501W		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	501	Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GTTCAATTTCCGGATCCAAAG	0.483000													35	91					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98555693	98555693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98555693C>T	ENST00000359863.4	+	43	6509	c.6300C>T	c.(6298-6300)ttC>ttT	p.F2100F	TRRAP_ENST00000355540.3_Silent_p.F2082F|TRRAP_ENST00000446306.3_Silent_p.F2081F	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2100	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGTGAACTTCCTTATCCGCG	0.567000													12	33					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4832579	4832579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:4832579G>A	ENST00000378191.4	+	4	1538	c.1157G>A	c.(1156-1158)gGa>gAa	p.G386E	AJAP1_ENST00000378190.3_Missense_Mutation_p.G386E	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	386	Targeting signals.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		ACATTTAATGGAAACCGGTAA	0.602000													13	25					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34851459	34851459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34851459G>A	ENST00000360581.1	+	4	590	c.462G>A	c.(460-462)atG>atA	p.M154I	NPSR1_ENST00000359791.1_Missense_Mutation_p.M154I|NPSR1_ENST00000381539.3_Missense_Mutation_p.M154I|NPSR1_ENST00000381542.1_Intron|NPSR1_ENST00000531252.1_Missense_Mutation_p.M143I	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	154						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	TCTACCCCATGAAGTTCCTTC	0.458000													44	113					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513605	99513605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:99513605G>A	ENST00000261037.3	+	5	1240	c.860G>A	c.(859-861)gGa>gAa	p.G287E	COL8A1_ENST00000273342.4_Missense_Mutation_p.G287E	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	287	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGCCCCCTGGGAAAGCCAGGG	0.667000													9	32					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7673059	7673059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7673059C>T	ENST00000446248.2	+	7	851	c.750C>T	c.(748-750)ttC>ttT	p.F250F	CAMSAP3_ENST00000160298.4_Silent_p.F223F	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	223	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CCCCCTGCTTCCCGACGGTGA	0.667000													23	66					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176671814	176671814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176671814C>T	ENST00000367662.3	+	9	4472	c.3308C>T	c.(3307-3309)tCg>tTg	p.S1103L		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1103					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.S1103L(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGAGAAGCTTCGCCTCCTCTG	0.493000													24	80					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48389692	48389692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48389692C>T	ENST00000380518.3	-	9	784	c.620G>A	c.(619-621)gGa>gAa	p.G207E	COL2A1_ENST00000337299.6_Missense_Mutation_p.G138E	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	207	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TCCTCGAGGTCCCATGGGGCC	0.542000													31	62					0	0	1	0	0
NR5A1	2516	broad.mit.edu	37	9	127262851	127262851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127262851G>A	ENST00000373588.4	-	4	584	c.388C>T	c.(388-390)Ccg>Tcg	p.P130S		NM_004959.4	NP_004950.2	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	130					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			lung(1)|upper_aerodigestive_tract(1)	2						GGGGGCGGCGGGGGCACCCCC	0.701000													5	25					0	0	1	0	0
SERPINB11	89778	broad.mit.edu	37	18	61390475	61390475	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61390475G>A	ENST00000544088.1	+	0	1083				SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000538847.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				GGATGTCAGCGAAGAGGGCAC	0.498000													10	53					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73462316	73462316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73462316C>T	ENST00000224721.6	+	23	2618	c.2613C>T	c.(2611-2613)ccC>ccT	p.P871P	CDH23_ENST00000299366.7_Silent_p.P911P	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	866	Cadherin 8.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GTGGCAGGCCCCCTCTGAAAG	0.567000													61	188					0	0	1	0	0
ADRB2	154	broad.mit.edu	37	5	148207537	148207537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148207537C>T	ENST00000305988.4	+	1	1382	c.1143C>T	c.(1141-1143)ctC>ctT	p.L381L		NM_000024.5	NP_000015.1	P07550	ADRB2_HUMAN	adrenoceptor beta 2, surface	381					activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(3)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	GTGAAGACCTCCCAGGCACGG	0.483000													7	72					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85500354	85500354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:85500354C>T	ENST00000393217.2	+	15	3399	c.3338C>T	c.(3337-3339)tCt>tTt	p.S1113F		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1113										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CATGAATTGTCTCTTACTGGA	0.338000													25	83					0	0	1	0	0
TAL1	6886	broad.mit.edu	37	1	47685771	47685771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47685771G>A	ENST00000371883.3	-	4	1199	c.623C>T	c.(622-624)gCc>gTc	p.A208V	TAL1_ENST00000459729.1_5'UTR|TAL1_ENST00000371884.2_Missense_Mutation_p.A206V|TAL1_ENST00000294339.3_Missense_Mutation_p.A206V			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	206	Helix-loop-helix motif.				basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						CTCGGCAAAGGCCCCGTTCAC	0.557000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								19	51					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447993	24447993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24447993G>A	ENST00000270800.1	-	7	1065	c.1027C>T	c.(1027-1029)Ccc>Tcc	p.P343S		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	343						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		AGGATCTGGGGAGGTGGCACG	0.627000													30	61					0	0	1	0	0
ZNF569	148266	broad.mit.edu	37	19	37905027	37905027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37905027G>A	ENST00000316950.6	-	6	1090	c.533C>T	c.(532-534)tCa>tTa	p.S178L	ZNF569_ENST00000392150.2_Missense_Mutation_p.S19L|ZNF569_ENST00000392149.2_Missense_Mutation_p.S178L	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAAATGGGATGAGCTATTACC	0.353000													30	46					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29301113	29301113	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:29301113G>A	ENST00000378993.1	+	3	814	c.141G>A	c.(139-141)gaG>gaA	p.E47E	IL1RAPL1_ENST00000302196.4_Silent_p.E47E	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	47	Ig-like C2-type 1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TGGTGGGAGAGCCTGTTCGAA	0.393000													27	19					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158369140	158369140	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158369140G>A	ENST00000334438.1	-	1	116	c.117C>T	c.(115-117)atC>atT	p.I39I		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TGGCCACCAGGATTGTCAAGT	0.483000													24	36					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6189094	6189094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6189094C>T	ENST00000262450.3	-	23	3522	c.3423G>A	c.(3421-3423)aaG>aaA	p.K1141K	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1141	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TCATCACCTTCTTGTTCTGGC	0.647000													24	36					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75387345	75387345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:75387345C>T	ENST00000297784.5	+	13	1298	c.758C>T	c.(757-759)tCc>tTc	p.S253F	TMC1_ENST00000340019.3_Missense_Mutation_p.S253F|TMC1_ENST00000396237.3_Missense_Mutation_p.S253F	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	253					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						GCACAATATTCCGTTCTCTTT	0.383000													27	260					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256617	16256617	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16256617C>T	ENST00000375759.3	+	11	4086	c.3882C>T	c.(3880-3882)gtC>gtT	p.V1294V		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1294					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ATGAAAAAGTCCTCCCCTATT	0.428000													34	90					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9971349	9971349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9971349C>T	ENST00000264833.4	-	2	370	c.185G>A	c.(184-186)aGt>aAt	p.S62N		NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	62						extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						CAGCTCCCGACTCCTGCCATC	0.632000													3	11					0	0	1	0	0
TKTL1	8277	broad.mit.edu	37	X	153541044	153541044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153541044C>T	ENST00000369915.3	+	6	973	c.784C>T	c.(784-786)Ccc>Tcc	p.P262S	TKTL1_ENST00000369912.2_Missense_Mutation_p.P206S|TKTL1_ENST00000217905.7_Intron	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	262					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGACCCACAGCCCCCCATTGA	0.468000													36	27					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33144259	33144259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33144259G>A	ENST00000341947.2	-	27	2347	c.2120C>T	c.(2119-2121)cCc>cTc	p.P707L	COL11A2_ENST00000374714.1_Missense_Mutation_p.P681L|COL11A2_ENST00000361917.1_Missense_Mutation_p.P600L|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000395197.1_Missense_Mutation_p.P647L|COL11A2_ENST00000374713.1_Missense_Mutation_p.P660L|COL11A2_ENST00000374712.1_Missense_Mutation_p.P626L|COL11A2_ENST00000374708.4_Missense_Mutation_p.P621L|COL11A2_ENST00000357486.1_Missense_Mutation_p.P686L	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	707	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						AGGTCCAGAGGGACCCTGGAA	0.547000													10	23					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149500563	149500563	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149500563G>A	ENST00000378016.2	+	0	7964							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATACTCCCAGGATGCCGCTGT	0.677000													12	38					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071252	9071252	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9071252G>A	ENST00000397910.4	-	3	16397	c.16194C>T	c.(16192-16194)atC>atT	p.I5398I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5400	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCATGAGTGATGCTGCTCA	0.507000													124	279					0	0	1	0	0
FRZB	2487	broad.mit.edu	37	2	183731065	183731065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:183731065G>A	ENST00000295113.4	-	1	825	c.216C>T	c.(214-216)ttC>ttT	p.F72F		NM_001463.3	NP_001454.2	Q92765	SFRP3_HUMAN	frizzled-related protein	72	FZ.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			GCAGACCTTCGAACTGCTCGA	0.602000													26	46					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79032165	79032165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:79032165G>A	ENST00000446378.2	+	2	7608	c.7577G>A	c.(7576-7578)aGa>aAa	p.R2526K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2526						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TACAATGAAAGACCCAAAATC	0.378000													15	33					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583248	82583248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82583248C>T	ENST00000423517.2	-	5	7358	c.7021G>A	c.(7021-7023)Gat>Aat	p.D2341N	PCLO_ENST00000333891.8_Missense_Mutation_p.D2341N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2272	Poly-Pro.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGTGGGTGATCAAACACGGTT	0.423000													38	100					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152278822	152278822	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152278822G>A	ENST00000368799.1	-	3	8575	c.8540C>T	c.(8539-8541)tCa>tTa	p.S2847L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2847	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGTCTCCTGATTGTTCCTC	0.567000									Ichthyosis				114	779					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26242168	26242168	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26242168G>A	ENST00000335473.7	+	19	3720	c.3470G>A	c.(3469-3471)aGc>aAc	p.S1157N	MYO18B_ENST00000536101.1_Missense_Mutation_p.S1157N|MYO18B_ENST00000407587.2_Missense_Mutation_p.S1158N	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1157	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTGCAGAGGAGCCGCATGGTG	0.672000													12	32					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61508254	61508254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:61508254G>A	ENST00000398571.2	-	38	5198	c.5122C>T	c.(5122-5124)Cct>Tct	p.P1708S		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1708					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TGAGCATCAGGAAGAAATTTC	0.388000													8	28					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066520	9066520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9066520G>A	ENST00000397910.4	-	3	21129	c.20926C>T	c.(20926-20928)Ccc>Tcc	p.P6976S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6978	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTACCAGTGGGGACTTCTGAA	0.483000													59	112					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89979796	89979796	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89979796G>A	ENST00000405460.2	+	28	6154	c.6058G>A	c.(6058-6060)Gat>Aat	p.D2020N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2020					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AACACTAGATGATATGGAAAA	0.393000													15	43					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874347	36874347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36874347G>A	ENST00000301807.6	-	21	6842	c.4945C>T	c.(4945-4947)Cct>Tct	p.P1649S	TRANK1_ENST00000429976.2_Missense_Mutation_p.P2199S|TRANK1_ENST00000428977.2_Missense_Mutation_p.P1649S	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2199					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAGATTTTAGGGAATACTTTT	0.403000													18	43					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10545978	10545978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10545978G>A	ENST00000583535.1	-	16	1731	c.1644C>T	c.(1642-1644)tcC>tcT	p.S548S	MYH3_ENST00000226209.7_Silent_p.S548S	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	548	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TGTTCTTGAAGGAGGTGTCTG	0.512000													47	79					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49671965	49671965	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49671965G>A	ENST00000561648.1	-	4	1151	c.1098C>T	c.(1096-1098)tcC>tcT	p.S366S	ZNF423_ENST00000562871.1_Silent_p.S306S|ZNF423_ENST00000535559.1_Silent_p.S249S|ZNF423_ENST00000567169.1_Silent_p.S249S|ZNF423_ENST00000562520.1_Silent_p.S306S|ZNF423_ENST00000563137.2_Silent_p.S306S|ZNF423_ENST00000262383.2_Silent_p.S366S	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	366					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CGCTGCTCATGGAGGCCACGC	0.662000													4	26					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158623135	158623135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158623135G>A	ENST00000368148.3	-	22	3297	c.3117C>T	c.(3115-3117)ttC>ttT	p.F1039F	SPTA1_ENST00000368147.3_Silent_p.F1039F	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1039					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.F1039F(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGAGCATCGGGAACTCATCGT	0.562000													40	85					0	0	1	0	0
IL22RA2	116379	broad.mit.edu	37	6	137466765	137466765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:137466765G>A	ENST00000296980.2	-	7	1088	c.788C>T	c.(787-789)cCa>cTa	p.P263L	IL22RA2_ENST00000339602.3_3'UTR|IL22RA2_ENST00000349184.4_Missense_Mutation_p.P231L	NM_052962.2	NP_443194.1	Q969J5	I22R2_HUMAN	interleukin 22 receptor, alpha 2	263	Fibronectin type-III 3.				regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	interleukin-22 receptor activity			endometrium(1)|large_intestine(1)|lung(3)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000313)|OV - Ovarian serous cystadenocarcinoma(155;0.00407)		CACAAGTCATGGAATTTCCAC	0.403000													21	24					0	0	1	0	0
PAXIP1	22976	broad.mit.edu	37	7	154767930	154767930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:154767930G>A	ENST00000404141.1	-	6	704	c.550C>T	c.(550-552)Cgt>Tgt	p.R184C	PAXIP1_ENST00000397192.1_Missense_Mutation_p.R184C|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	184					DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		ATAATCAGACGAGGATGATAA	0.398000													8	38					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71709037	71709037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71709037C>T	ENST00000258104.3	+	3	450	c.173C>T	c.(172-174)cCc>cTc	p.P58L	DYSF_ENST00000410041.1_Missense_Mutation_p.P59L|DYSF_ENST00000429174.2_Missense_Mutation_p.P58L|DYSF_ENST00000409744.1_Missense_Mutation_p.P59L|DYSF_ENST00000410020.3_Missense_Mutation_p.P59L|DYSF_ENST00000394120.2_Missense_Mutation_p.P59L|DYSF_ENST00000409366.1_Missense_Mutation_p.P59L|DYSF_ENST00000409582.3_Missense_Mutation_p.P58L|DYSF_ENST00000413539.2_Missense_Mutation_p.P58L|DYSF_ENST00000409651.1_Missense_Mutation_p.P59L|DYSF_ENST00000409762.1_Missense_Mutation_p.P58L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	58	C2 1.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						AAGGGCATCCCCCTGGACCAG	0.537000													11	25					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59557575	59557575	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59557575G>A	ENST00000393853.4	+	8	1079	c.916G>A	c.(916-918)Gag>Aag	p.E306K	TBX4_ENST00000589449.1_3'UTR|TBX4_ENST00000240335.1_Missense_Mutation_p.E306K			P57082	TBX4_HUMAN	T-box 4	306					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CTACCAGCACGAGAACGGGGC	0.637000													57	98					0	0	1	0	0
UNC93B1	81622	broad.mit.edu	37	11	67766748	67766748	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67766748G>A	ENST00000227471.2	-	5	661	c.582C>T	c.(580-582)tcC>tcT	p.S194S	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	194					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome											CCTTGTAGTGGGAGTACTCAT	0.607000													13	22					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940198	68940198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:68940198G>A	ENST00000433211.1	-	7	1098	c.924C>T	c.(922-924)atC>atT	p.I308I	CTNNA3_ENST00000545309.1_Silent_p.I308I|CTNNA3_ENST00000494580.1_5'UTR|CTNNA3_ENST00000373744.4_Silent_p.I308I	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	308					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						CAGCCCCACTGATAATGGCTT	0.478000													25	60					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124399574	124399574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124399574G>A	ENST00000338354.3	+	52	6680	c.6574G>A	c.(6574-6576)Gac>Aac	p.D2192N	DMBT1_ENST00000344338.3_Missense_Mutation_p.D2182N|DMBT1_ENST00000368955.3_Missense_Mutation_p.D2182N|DMBT1_ENST00000359586.6_Missense_Mutation_p.D912N|DMBT1_ENST00000330163.4_Missense_Mutation_p.D1564N|DMBT1_ENST00000368956.2_Missense_Mutation_p.D1564N|DMBT1_ENST00000368909.3_Missense_Mutation_p.D2192N			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2192	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGACACCATCGACTATTCCAA	0.517000													19	40					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53009975	53009975	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53009975C>T	ENST00000305748.3	-	2	671	c.637G>A	c.(637-639)Gaa>Aaa	p.E213K		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	213	Coil 1B.|Rod.					keratin filament	structural molecule activity	p.E213*(1)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCACCACTTCGCGCACGCTC	0.627000													27	127					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10263371	10263371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10263371C>T	ENST00000418404.3	-	6	714	c.551G>A	c.(550-552)gGg>gAg	p.G184E	MYH13_ENST00000570743.1_Missense_Mutation_p.G184E|MYH13_ENST00000252172.4_Missense_Mutation_p.G184E			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	184	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CACAGTCTTCCCAGCCCCGGA	0.493000													28	32					0	0	1	0	0
LRCH4	4034	broad.mit.edu	37	7	100179450	100179450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100179450G>A	ENST00000310300.6	-	4	600	c.548C>T	c.(547-549)tCc>tTc	p.S183F	LRCH4_ENST00000497245.1_5'UTR	NM_002319.3	NP_002310.2	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 4	183					nervous system development	PML body	protein binding			NS(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	23	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTCCCGCAGGGAAGAGAGGCC	0.587000													18	66					0	0	1	0	0
GPIHBP1	338328	broad.mit.edu	37	8	144297308	144297308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144297308C>T	ENST00000330824.2	+	4	545	c.470C>T	c.(469-471)cCc>cTc	p.P157L		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	157					cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GCAGGCGGCCCCCGGGGCAGC	0.687000													10	32					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6527210	6527210	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6527210C>T	ENST00000263125.5	-	10	1021	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K	PRKCQ_ENST00000539722.1_Missense_Mutation_p.E183K|PRKCQ_ENST00000397176.2_Missense_Mutation_p.E308K	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	308					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						AAGATCTGTTCAGTATCTCTT	0.507000													36	145					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784541	9784541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9784541G>A	ENST00000304374.2	+	1	1284	c.888G>A	c.(886-888)aaG>aaA	p.K296K		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	296					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	AGGTTCTCAAGACCCTGTCGG	0.627000													11	99					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8531249	8531249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8531249C>T	ENST00000348943.3	+	8	876	c.644C>T	c.(643-645)tCc>tTc	p.S215F	HNRNPM_ENST00000325495.4_Missense_Mutation_p.S254F	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	254	RRM 2.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						TTTGAACAGTCCATTGAAGCT	0.398000													51	137					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48614119	48614119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48614119G>A	ENST00000328333.8	-	67	5797	c.5690C>T	c.(5689-5691)cCt>cTt	p.P1897L	COL7A1_ENST00000454817.1_Intron	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1897	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGGCCAGGAGGGCCCACTGG	0.612000													4	8					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103063558	103063558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103063558C>T	ENST00000264260.2	+	10	1690	c.1101C>T	c.(1099-1101)acC>acT	p.T367T	IL18RAP_ENST00000409369.1_Silent_p.T225T	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	367					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TGCTTGGCACCATCGGGACCC	0.592000													81	226					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87591451	87591451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87591451C>T	ENST00000320005.5	-	16	1858	c.1811G>A	c.(1810-1812)cGa>cAa	p.R604Q		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	604					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						ATTGGCAGTTCGACGGTTTCC	0.423000													49	183					0	0	1	0	0
SLC22A16	85413	broad.mit.edu	37	6	110760036	110760036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110760036G>A	ENST00000368919.3	-	5	1264	c.1198C>T	c.(1198-1200)Ccc>Tcc	p.P400S	SLC22A16_ENST00000439654.1_Missense_Mutation_p.P400S|SLC22A16_ENST00000330550.4_Missense_Mutation_p.P366S	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	400					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		GTGTAGGCGGGAATTTCCACT	0.542000													23	28					0	0	1	0	0
ALDH1A3	220	broad.mit.edu	37	15	101436147	101436147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101436147C>T	ENST00000329841.5	+	7	1208	c.676C>T	c.(676-678)Cct>Tct	p.P226S	RP11-66B24.4_ENST00000560351.1_RNA|ALDH1A3_ENST00000346623.6_Missense_Mutation_p.P119S	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	226					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	GGCCGGGTTCCCTCCAGGAGT	0.557000													10	32					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746666	77746666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:77746666C>T	ENST00000409088.3	-	3	743	c.329G>A	c.(328-330)aGa>aAa	p.R110K	LRRTM4_ENST00000409884.1_Missense_Mutation_p.R110K|LRRTM4_ENST00000409911.1_Missense_Mutation_p.R111K|LRRTM4_ENST00000409093.1_Missense_Mutation_p.R110K|LRRTM4_ENST00000409282.1_Missense_Mutation_p.R111K	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	110						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		TTCTTTCAGTCTACGGATCCC	0.388000													13	54					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156955916	156955916	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156955916G>T	ENST00000368194.3	-	2	1121	c.82C>A	c.(82-84)Cct>Act	p.P28T	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.P28T	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	28					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGTGGGAAGGGGACTTGCGC	0.532000													32	83					3.03874e-20	3.05718e-20	1	1	0
CST8	10047	broad.mit.edu	37	20	23476501	23476501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:23476501C>T	ENST00000246012.1	+	4	736	c.379C>T	c.(379-381)Ccc>Tcc	p.P127S		NM_005492.2	NP_005483.1	O60676	CST8_HUMAN	cystatin 8 (cystatin-related epididymal specific)	127						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(9)|skin(2)	16	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AGGAGCACTTCCCTGGAATGG	0.358000													14	150					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35406833	35406833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:35406833C>T	ENST00000287272.2	+	2	147	c.127C>T	c.(127-129)Ccc>Tcc	p.P43S	UNC5D_ENST00000416672.1_Missense_Mutation_p.P43S|UNC5D_ENST00000420357.1_Missense_Mutation_p.P43S|UNC5D_ENST00000404895.2_Missense_Mutation_p.P43S|UNC5D_ENST00000453357.2_Missense_Mutation_p.P38S			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	43					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CGAAGCCCTTCCCGAATCCAT	0.468000													6	68					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107096780	107096780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:107096780G>A	ENST00000261058.1	+	1	593	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	116										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						GAATGTTAATGAAGACAAACA	0.378000													19	43					0	0	1	0	0
PPP1R14D	54866	broad.mit.edu	37	15	41108451	41108451	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41108451C>T	ENST00000299174.5	-	2	323	c.255_splice	c.e2-1	p.D86_splice	PPP1R14D_ENST00000427255.2_Splice_Site_p.G124_splice	NM_017726.7	NP_060196.1	Q9NXH3	PP14D_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14D	86					regulation of phosphorylation	cytoplasm	protein phosphatase inhibitor activity			breast(1)|large_intestine(2)|lung(2)|skin(1)	6		all_cancers(109;6.29e-14)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.88e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GTTGCTTGATCCTATTTGGAA	0.527000													7	55					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14106581	14106581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:14106581C>T	ENST00000235372.7	+	8	3147	c.2291C>T	c.(2290-2292)aCc>aTc	p.T764I	PRDM2_ENST00000343137.4_Missense_Mutation_p.T563I|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.T563I|PRDM2_ENST00000311066.5_Missense_Mutation_p.T764I|PRDM2_ENST00000505823.1_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	764						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GCAGCATGGACCGATGCCGGG	0.517000													12	116					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19404516	19404516	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19404516G>A	ENST00000375267.2	-	104	15281	c.15278C>T	c.(15277-15279)tCc>tTc	p.S5093F	UBR4_ENST00000543981.1_Missense_Mutation_p.S757F|UBR4_ENST00000375226.2_Missense_Mutation_p.S5069F|UBR4_ENST00000375224.1_Missense_Mutation_p.S800F|UBR4_ENST00000375254.3_Missense_Mutation_p.S5093F|UBR4_ENST00000429347.2_Missense_Mutation_p.S616F|UBR4_ENST00000375217.2_Missense_Mutation_p.S5086F|UBR4_ENST00000375225.3_Missense_Mutation_p.S168F			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	5093					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AAAGAGAAGGGAAGAACGGTA	0.473000													13	29					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226608	23226608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23226608G>A	ENST00000300061.2	+	13	1911	c.1768G>A	c.(1768-1770)Ggc>Agc	p.G590S		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	590					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TAGCCCACAGGGCCAGGACAA	0.597000													35	105					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62020413	62020413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62020413G>A	ENST00000578147.1	-	23	4137	c.4061C>T	c.(4060-4062)gCc>gTc	p.A1354V	SCN4A_ENST00000435607.1_Missense_Mutation_p.A1354V			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1354					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GATGTCGAAGGCCTGCTTCGT	0.557000													45	78					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94083510	94083510	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94083510T>G	ENST00000553484.1	+	29	4304	c.4150T>G	c.(4150-4152)Tta>Gta	p.L1384V	UNC79_ENST00000555664.1_Missense_Mutation_p.L1362V|UNC79_ENST00000256339.4_Missense_Mutation_p.L1185V|UNC79_ENST00000393151.2_Missense_Mutation_p.L1362V			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1362						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCTTCTCCCCTTAGTGGTTCA	0.433000													26	122					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28755048	28755048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:28755048C>T	ENST00000422425.2	+	9	586	c.542C>T	c.(541-543)cCc>cTc	p.P181L	PLB1_ENST00000327757.5_Missense_Mutation_p.P181L	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	181	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TACCTGTGCCCCTCTGCTCAA	0.478000													33	159					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133805038	133805038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133805038C>T	ENST00000372338.4	-	2	710	c.468G>A	c.(466-468)acG>acA	p.T156T	FIBCD1_ENST00000253018.4_5'UTR|FIBCD1_ENST00000448616.1_Silent_p.T156T|FIBCD1_ENST00000372337.2_5'UTR	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	156					signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CCATGCACTCCGTCTGCAGCT	0.721000													8	21					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48164723	48164723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48164723C>T	ENST00000311303.3	-	8	1557	c.1212G>A	c.(1210-1212)gcG>gcA	p.A404A	ABCC12_ENST00000416054.1_Silent_p.A404A|ABCC12_ENST00000448542.1_Silent_p.A404A	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	404						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GAGAGACATTCGCTTCAGCCA	0.423000													20	40					0	0	1	0	0
MDK	4192	broad.mit.edu	37	11	46403895	46403895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:46403895G>A	ENST00000405308.2	+	3	557	c.128G>A	c.(127-129)gGg>gAg	p.G43E	MDK_ENST00000407067.1_Missense_Mutation_p.G43E|MDK_ENST00000395565.1_Missense_Mutation_p.G43E|MDK_ENST00000359803.3_Missense_Mutation_p.G43E|MDK_ENST00000395566.4_Missense_Mutation_p.G43E|MDK_ENST00000395569.4_Intron|MDK_ENST00000533283.1_3'UTR	NM_001270550.1	NP_001257479.1	P21741	MK_HUMAN	midkine (neurite growth-promoting factor 2)	43					adrenal gland development|cell differentiation|nervous system development|positive regulation of cell division|response to wounding|signal transduction	extracellular region	growth factor activity|heparin binding			lung(1)	1				GBM - Glioblastoma multiforme(35;0.0252)|Lung(87;0.14)		TGGGCCTGGGGGCCCTGCACC	0.692000													5	13					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189060833	189060833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189060833C>T	ENST00000332517.3	+	1	261	c.121C>T	c.(121-123)Ctc>Ttc	p.L41F		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	41					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GGTGTGTCTCCTCAGGAGCTG	0.547000													87	206					0	0	1	0	0
IL32	9235	broad.mit.edu	37	16	3119116	3119116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3119116G>A	ENST00000525643.2	+	7	659	c.327G>A	c.(325-327)atG>atA	p.M109I	IL32_ENST00000551513.1_Missense_Mutation_p.M146I|IL32_ENST00000528163.2_Missense_Mutation_p.M109I|IL32_ENST00000552936.1_Missense_Mutation_p.M133I|IL32_ENST00000552356.1_Missense_Mutation_p.M89I|IL32_ENST00000526464.2_Missense_Mutation_p.M109I|IL32_ENST00000549213.1_Intron|IL32_ENST00000529550.1_Missense_Mutation_p.M109I|IL32_ENST00000530538.2_Missense_Mutation_p.M109I|IL32_ENST00000531965.1_Missense_Mutation_p.M99I|IL32_ENST00000396887.3_Intron|IL32_ENST00000008180.9_Missense_Mutation_p.M89I|IL32_ENST00000440815.3_Missense_Mutation_p.M109I|IL32_ENST00000325568.5_Missense_Mutation_p.M109I|IL32_ENST00000548652.1_Missense_Mutation_p.M100I|IL32_ENST00000548246.1_Missense_Mutation_p.M69I|IL32_ENST00000533097.2_Missense_Mutation_p.M109I|IL32_ENST00000534507.1_Missense_Mutation_p.M155I|IL32_ENST00000548476.1_Missense_Mutation_p.M155I|IL32_ENST00000552664.1_Missense_Mutation_p.M109I|IL32_ENST00000396890.2_Missense_Mutation_p.M155I|IL32_ENST00000444393.3_Missense_Mutation_p.M109I|IL32_ENST00000382213.3_Missense_Mutation_p.M100I|IL32_ENST00000530890.1_Missense_Mutation_p.M89I|IL32_ENST00000551122.1_Intron|IL32_ENST00000529699.1_Missense_Mutation_p.M89I			P24001	IL32_HUMAN	interleukin 32	155					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						ACAAGGTCATGAGATGGTTCC	0.607000													8	21					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86959980	86959980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86959980G>A	ENST00000234701.3	+	12	2142	c.1791G>A	c.(1789-1791)acG>acA	p.T597T	CLCA1_ENST00000394711.1_Silent_p.T597T			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	597					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CTTCCAAAACGAACAAGGACA	0.517000													12	43					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51729087	51729087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51729087C>T	ENST00000436584.2	+	2	121	c.66C>T	c.(64-66)atC>atT	p.I22I	CD33_ENST00000262262.4_Silent_p.I149I|CD33_ENST00000391796.3_Silent_p.I149I|CD33_ENST00000421133.2_Silent_p.I22I			P20138	CD33_HUMAN	CD33 molecule	149	Ig-like V-type.		W -> R (in dbSNP:rs35814802).		cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AAATCCTCATCCCTGGCACTC	0.572000													47	96					0	0	1	0	0
SH3BGRL3	83442	broad.mit.edu	37	1	26607282	26607282	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26607282C>T	ENST00000270792.5	+	2	1055	c.75C>T	c.(73-75)acC>acT	p.T25T	SH3BGRL3_ENST00000319041.6_Silent_p.T25T	NM_031286.3	NP_112576.1	Q9H299	SH3L3_HUMAN	SH3 domain binding glutamic acid-rich protein like 3	25	Glutaredoxin.				cell redox homeostasis	cytoplasm|nucleus	electron carrier activity|protein disulfide oxidoreductase activity						all_cancers(24;1.16e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.22e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00751)|READ - Rectum adenocarcinoma(331;0.0649)		GCGAGGTGACCCGAATCCTGG	0.587000													14	82					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858356	9858356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9858356C>T	ENST00000396573.2	-	14	3354	c.3045G>A	c.(3043-3045)aaG>aaA	p.K1015K	GRIN2A_ENST00000535259.1_Silent_p.K858K|GRIN2A_ENST00000404927.2_Silent_p.K1015K|GRIN2A_ENST00000562109.1_Silent_p.K1015K|GRIN2A_ENST00000330684.3_Silent_p.K1015K|GRIN2A_ENST00000396575.2_Silent_p.K1015K	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1015					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCACGGATTTCTTCCACAGCT	0.532000													36	74					0	0	1	0	0
GDF9	2661	broad.mit.edu	37	5	132197785	132197785	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132197785A>C	ENST00000378673.2	-	3	1727	c.861T>G	c.(859-861)ccT>ccG	p.P287P	GDF9_ENST00000296875.2_Silent_p.P287P			O60383	GDF9_HUMAN	growth differentiation factor 9	287					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACCCTGGGAAGGCCTCCTTT	0.512000													21	49					0	0	1	0	0
SLC2A4	6517	broad.mit.edu	37	17	7186949	7186949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7186949C>T	ENST00000317370.8	+	3	576	c.308C>T	c.(307-309)tCt>tTt	p.S103F	SLC2A4_ENST00000424875.2_Missense_Mutation_p.S93F|SLC2A4_ENST00000571308.1_Missense_Mutation_p.S103F|RP1-4G17.2_ENST00000576271.1_RNA	NM_001042.2	NP_001033.1	P14672	GTR4_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 4	103					carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding			breast(1)|endometrium(3)|large_intestine(7)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17						GGTATCATCTCTCAGTGGCTT	0.617000													26	45					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129039953	129039953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:129039953G>A	ENST00000274487.4	+	21	3308	c.3163G>A	c.(3163-3165)Ggc>Agc	p.G1055S	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1055	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GTGTGGCAAAGGCATACGTCA	0.423000													53	128					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997547	46997547	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46997547C>T	ENST00000599531.1	-	1	2208	c.1176G>A	c.(1174-1176)gaG>gaA	p.E392E	PNMAL2_ENST00000594749.1_Intron|PNMAL2_ENST00000377655.2_Intron	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	392										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CGCGGCCCGCCTCTTCCACCT	0.672000													6	30					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43212399	43212399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43212399C>T	ENST00000255226.6	+	5	1422	c.606C>T	c.(604-606)taC>taT	p.Y202Y	SLC14A2_ENST00000586448.1_Silent_p.Y202Y	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	202						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AGTTAGACTACTACTGGTGGC	0.552000													34	151					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626688	140626688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140626688C>T	ENST00000231173.3	+	1	1542	c.1542C>T	c.(1540-1542)ttC>ttT	p.F514F		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		514	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCACCTGTTCGCTCTCCAGT	0.692000													41	198					0	0	1	0	0
CALHM1	255022	broad.mit.edu	37	10	105215200	105215200	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105215200C>T	ENST00000329905.5	-	2	996	c.860G>A	c.(859-861)aGg>aAg	p.R287K	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	287						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						CAGCTTCTCCCTTTCCTCCTC	0.647000													15	27					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017381	93017381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:93017381C>T	ENST00000523629.1	-	6	1157	c.703G>A	c.(703-705)Gat>Aat	p.D235N	RUNX1T1_ENST00000521553.1_Missense_Mutation_p.D198N|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.D198N|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.D198N|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.D246N|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.D208N|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.D198N|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.D235N|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.D208N	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	235					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCGTTCACATCGAGAAGCAGC	0.552000													24	119					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125989806	125989806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125989806G>A	ENST00000319286.5	+	3	1450	c.1296G>A	c.(1294-1296)agG>agA	p.R432R		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	432					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R432R(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTCACCAAAGGACACATACAG	0.438000										HNSCC(60;0.17)			39	76					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28649015	28649015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28649015C>T	ENST00000280904.6	-	15	2796	c.2353G>A	c.(2353-2355)Gaa>Aaa	p.E785K	DSC2_ENST00000251081.6_Missense_Mutation_p.E785K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	785					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTCACCATTTCGATGGTCTCC	0.582000													14	60					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368336	18368336	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18368336G>A	ENST00000392413.3	-	4	3973	c.3758C>T	c.(3757-3759)cCt>cTt	p.P1253L	KIAA1683_ENST00000600328.2_Missense_Mutation_p.P1066L|KIAA1683_ENST00000600359.2_Missense_Mutation_p.P1020L	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	0						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						ACAGGTGCGAGGGCTGGAGCC	0.687000													5	14					0	0	1	0	0
GOLGA8IP	283796	broad.mit.edu	37	15	23262319	23262319	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23262319G>A	ENST00000450802.3	+	13	1274	c.1176G>A	c.(1174-1176)aaG>aaA	p.K392K																								AGCAAGTAAAGGAGCTACAGG	0.577000													10	36					0	0	1	0	0
AADAC	13	broad.mit.edu	37	3	151545614	151545614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151545614C>T	ENST00000232892.6	+	5	980	c.854C>T	c.(853-855)tCc>tTc	p.S285F	RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	285					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AATTGGAGTTCCCTGCTCCCT	0.383000													40	98					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47602361	47602361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47602361G>A	ENST00000273857.4	-	21	2815	c.2816C>T	c.(2815-2817)cCa>cTa	p.P939L	CORIN_ENST00000502252.1_Missense_Mutation_p.P872L|CORIN_ENST00000505909.1_Missense_Mutation_p.P902L|CORIN_ENST00000508498.1_Missense_Mutation_p.P800L	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	939	Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						CAGCTTAAATGGCACTGaatt	0.363000													17	37					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363473	22363473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22363473G>A	ENST00000397121.2	-	3	1363	c.1046C>T	c.(1045-1047)tCc>tTc	p.S349F		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAGGATTGAGGATCGATTAAA	0.403000													31	120					0	0	1	0	0
OTC	5009	broad.mit.edu	37	X	38262948	38262948	+	Missense_Mutation	SNP	G	G	A	rs72558413		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:38262948G>A	ENST00000039007.4	+	6	770	c.618G>A	c.(616-618)atG>atA	p.M206I	TM4SF2_ENST00000465127.1_Intron	NM_000531.5	NP_000522.3	P00480	OTC_HUMAN	ornithine carbamoyltransferase	206			M -> I (in OTCD).|M -> R (in OTCD; neonatal).		arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22					L-Citrulline(DB00155)|L-Ornithine(DB00129)	CCATCATGATGAGCGCAGCGA	0.483000													29	21					0	0	1	0	0
AGT	183	broad.mit.edu	37	1	230841825	230841825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230841825C>T	ENST00000366667.4	-	3	1192	c.978G>A	c.(976-978)caG>caA	p.Q326Q		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	326					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	AGAAGTTGTCCTGGATGTCAC	0.592000													26	101					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110809020	110809020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:110809020C>T	ENST00000282356.4	+	8	1035	c.637C>T	c.(637-639)Ctt>Ttt	p.L213F	CAMK4_ENST00000512453.1_Missense_Mutation_p.L213F	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	213	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		ACCTGAAATTCTTAGAGGTTG	0.318000													34	131					0	0	1	0	0
FGF7	2252	broad.mit.edu	37	15	49716709	49716709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:49716709G>A	ENST00000267843.4	+	2	826	c.215G>A	c.(214-216)cGa>cAa	p.R72Q	FGF7_ENST00000560270.1_Missense_Mutation_p.R72Q|FAM227B_ENST00000561064.1_Intron|FAM227B_ENST00000299338.6_Intron	NM_002009.3	NP_002000.1	P21781	FGF7_HUMAN	fibroblast growth factor 7	72					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	CTCTTCTGTCGAACACAGTGG	0.408000													30	68					0	0	1	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60028961	60028961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:60028961C>T	ENST00000586569.1	+	7	703	c.665C>T	c.(664-666)tCt>tTt	p.S222F	TNFRSF11A_ENST00000269485.7_Intron	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	222					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				CTCTTCGCGTCTGTGGCCCTG	0.408000													93	232					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189856244	189856244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189856244C>T	ENST00000304636.3	+	12	1054	c.884C>T	c.(883-885)gCt>gTt	p.A295V	COL3A1_ENST00000317840.5_Missense_Mutation_p.A295V	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	295	Triple-helical region.			NGA -> DGS (in Ref. 9; AA sequence).	axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GAAAATGGAGCTCCTGGACCC	0.318000													21	49					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145583659	145583659	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145583659C>T	ENST00000532887.1	+	3	1090	c.507C>T	c.(505-507)cgC>cgT	p.R169R	SLC52A2_ENST00000540505.1_Silent_p.R81R|SLC52A2_ENST00000329994.2_Silent_p.R169R|SLC52A2_ENST00000402965.1_Silent_p.R169R|SLC52A2_ENST00000527078.1_Silent_p.R169R|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000526891.1_3'UTR|SLC52A2_ENST00000530047.1_Silent_p.R169R			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	169						integral to plasma membrane	receptor activity|riboflavin transporter activity										GTGTGGGCCGCCTCGAGTGCC	0.667000													27	110					0	0	1	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67220438	67220438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:67220438G>A	ENST00000282670.2	+	2	225	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	TCTEX1D1_ENST00000491611.1_3'UTR	NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	33								p.E33K(1)		large_intestine(2)|lung(10)|skin(1)	13						TTGGCGAAAGGAAATTCATGG	0.338000													11	40					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767876	57767876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57767876G>A	ENST00000371030.2	+	1	1802	c.1802G>A	c.(1801-1803)aGa>aAa	p.R601K		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	601						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGCAAGGGCAGAGCGGGCGGC	0.622000													18	67					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2026901	2026901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2026901G>A	ENST00000262113.4	+	12	1490	c.1349G>A	c.(1348-1350)gGa>gAa	p.G450E	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	450	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTTTTTGAAGGAAGGTCTTAC	0.507000													99	200					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3686423	3686423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3686423C>T	ENST00000344754.4	-	3	673	c.674G>A	c.(673-675)aGg>aAg	p.R225K	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.R225K	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	225	Ig-like C2-type 1.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCTCTGAGCCCTGTGATTGGC	0.632000													29	71					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82835853	82835853	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82835853C>T	ENST00000265077.3	+	8	7596	c.7031C>T	c.(7030-7032)cCc>cTc	p.P2344L	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.P1357L|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2344	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GCAGAAGGACCCACGGTGGCA	0.468000													21	82					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191299	6191299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6191299G>A	ENST00000530810.1	-	1	339	c.258C>T	c.(256-258)atC>atT	p.I86I	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAGCCAAAAGATGGCTAGGG	0.493000													47	125					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179418650	179418650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179418650C>T	ENST00000589042.1	-	333	89412	c.89188G>A	c.(89188-89190)Gat>Aat	p.D29730N	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D27162N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D28089N|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D20857N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D20790N|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D20665N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28089	Fibronectin type-III 116.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAATAGGATCAGCAGCTTTG	0.393000													11	35					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55281307	55281307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55281307C>T	ENST00000336077.6	+	1	45	c.5C>T	c.(4-6)tCg>tTg	p.S2L	KIR2DL1_ENST00000291633.7_Missense_Mutation_p.S2L|KIR3DL1_ENST00000541392.1_Intron|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL4_ENST00000396284.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	2					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		AGCACCATGTCGCTCTTGGTC	0.587000											OREG0003674	type=REGULATORY REGION|Gene=KIR2DL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	24	89					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141543929	141543929	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141543929G>T	ENST00000442267.2	-	21	3295	c.3221C>A	c.(3220-3222)cCt>cAt	p.P1074H		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1074						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CTCCTTTGCAGGCTGGGCCAC	0.657000													7	24					1.06961e-07	1.07277e-07	1	1	0
COL6A6	131873	broad.mit.edu	37	3	130292924	130292924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130292924C>T	ENST00000358511.6	+	7	3133	c.3102C>T	c.(3100-3102)ctC>ctT	p.L1034L	COL6A6_ENST00000453409.2_Silent_p.L1034L	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1034	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ATGTCAGCCTCAACAGAGTGC	0.418000													12	33					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41442369	41442369	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41442369G>A	ENST00000599198.1	+	0	461					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						AGGGACTTCGGGATGGGAAAG	0.562000													13	27					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126410110	126410110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:126410110C>T	ENST00000339582.2	-	7	1974	c.1166G>A	c.(1165-1167)cGa>cAa	p.R389Q	GRM8_ENST00000405249.1_Missense_Mutation_p.R389Q|GRM8_ENST00000444921.2_Missense_Mutation_p.R389Q|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Missense_Mutation_p.R389Q			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	389					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCGAGCAATTCGCTCCAGCCC	0.383000										HNSCC(24;0.065)			7	17					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42375973	42375973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42375973C>T	ENST00000290472.3	-	7	570	c.476G>A	c.(475-477)cGa>cAa	p.R159Q		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	159					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TGACAGCTCTCGGGCCTGGGG	0.602000													42	87					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11117598	11117598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:11117598G>A	ENST00000304623.8	-	13	2430	c.2241C>T	c.(2239-2241)atC>atT	p.I747I	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Silent_p.I410I|CTNND2_ENST00000511377.1_Silent_p.I656I|CTNND2_ENST00000458100.2_Silent_p.I314I|CTNND2_ENST00000359640.2_Silent_p.I747I	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	747					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GCGCAGACTGGATCACGTACA	0.507000													56	122					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54804695	54804695	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54804695C>T	ENST00000306858.7	+	5	1042	c.926C>T	c.(925-927)tCg>tTg	p.S309L		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	309										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TACCAGCATTCGGTGTCTTCA	0.433000													26	95					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241007	126241007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126241007G>A	ENST00000394329.3	+	1	3454	c.3441G>A	c.(3439-3441)gaG>gaA	p.E1147E		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1147	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAGATTTTGAGTTGCATGCCA	0.448000													64	150					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907225	164907225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164907225C>T	ENST00000475390.1	-	2	1837	c.1394G>A	c.(1393-1395)gGc>gAc	p.G465D	SLITRK3_ENST00000241274.3_Missense_Mutation_p.G465D			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	465						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TATATCGTTGCCATTAAGGAA	0.463000										HNSCC(40;0.11)			14	44					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234878916	234878916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234878916C>T	ENST00000324695.4	+	17	2241	c.2201C>T	c.(2200-2202)cCc>cTc	p.P734L	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	734						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TTCACCTCCCCCTTCGTGGTC	0.542000													90	255					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36081686	36081686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:36081686G>A	ENST00000360731.3	+	6	1803	c.1803G>A	c.(1801-1803)agG>agA	p.R601R	CLIC6_ENST00000349499.2_Silent_p.R583R			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	601	GST C-terminal.					chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						AGGCCCTGAGGAAGCTGGATA	0.453000													28	75					0	0	1	0	0
NADK	65220	broad.mit.edu	37	1	1686834	1686834	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1686834G>A	ENST00000344463.4	-	9	1323	c.1102C>T	c.(1102-1104)Caa>Taa	p.Q368*	NADK_ENST00000342348.5_Nonsense_Mutation_p.Q191*|NADK_ENST00000341991.3_Nonsense_Mutation_p.Q223*|NADK_ENST00000378625.1_Nonsense_Mutation_p.Q368*|NADK_ENST00000341426.5_Nonsense_Mutation_p.Q223*			O95544	NADK_HUMAN	NAD kinase	223					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding			NS(1)|autonomic_ganglia(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|stomach(1)|urinary_tract(1)	17	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		TGAGTAACTTGGGACTGAAAG	0.577000													19	260					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177694313	177694313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:177694313G>A	ENST00000390654.3	-	8	874	c.517C>T	c.(517-519)Ccc>Tcc	p.P173S	COL23A1_ENST00000407622.1_Missense_Mutation_p.P137S	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	173	Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CTTACCCGGGGGCCAAAGTCT	0.557000													7	40					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878387	150878387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150878387C>T	ENST00000422024.1	-	3	1003	c.878G>A	c.(877-879)gGc>gAc	p.G293D	ASB10_ENST00000420175.2_Missense_Mutation_p.G248D|ASB10_ENST00000377867.3_Missense_Mutation_p.G233D|ASB10_ENST00000434669.1_Missense_Mutation_p.G293D|ASB10_ENST00000275838.1_Missense_Mutation_p.G248D	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	248					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGGTCCAGCCTTCGGCATT	0.657000													10	28					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180381713	180381713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:180381713C>T	ENST00000273654.4	-	8	1023	c.404G>A	c.(403-405)cGa>cAa	p.R135Q	CCDC39_ENST00000442201.2_Missense_Mutation_p.R51Q			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	51					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AGAATTAATTCGCTCTTCATA	0.328000													30	83					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428313	128428313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:128428313G>A	ENST00000465342.2	+	2	1359	c.202G>A	c.(202-204)Gag>Aag	p.E68K	CASC8_ENST00000502082.1_RNA|CASC8_ENST00000501396.1_RNA|CASC8_ENST00000523825.1_RNA|POU5F1B_ENST00000391675.1_Missense_Mutation_p.E68K			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	68						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						CCCGCCGTATGAGTTATGTGG	0.657000													15	24					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52571156	52571156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52571156G>A	ENST00000443683.2	-	4	495	c.8C>T	c.(7-9)tCa>tTa	p.S3L	MYO5C_ENST00000541028.1_5'UTR|MYO5C_ENST00000261839.7_Silent_p.I121I			Q9NQX4	MYO5C_HUMAN	myosin VC	0	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AGGCGTGGATGATGGCATCTC	0.493000													40	79					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651838	84651838	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84651838G>T	ENST00000286744.5	+	21	3682	c.3458G>T	c.(3457-3459)gGg>gTg	p.G1153V	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G1153V	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1153						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAGCTCAGAGGGGAAACAGGG	0.547000													14	48					4.93089e-13	4.955e-13	1	1	0
GPR98	84059	broad.mit.edu	37	5	89948163	89948163	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89948163G>A	ENST00000405460.2	+	19	3513	c.3416_splice	c.e19-1	p.W1139_splice		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1139					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATTTTGTAGGATTTTGAGGC	0.343000													39	111					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69536064	69536064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69536064C>T	ENST00000338206.5	-	1	282	c.273G>A	c.(271-273)ctG>ctA	p.L91L		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	91					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CGAGAATTTTCAGAAGAGAAT	0.294000													43	105					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67136784	67136784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67136784G>A	ENST00000284425.2	-	2	235	c.61C>T	c.(61-63)Ctt>Ttt	p.L21F	ABCA6_ENST00000590645.1_Missense_Mutation_p.L21F	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	21					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CATTTCTTAAGAAAATTCTTG	0.363000													23	90					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884747	39884747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39884747C>T	ENST00000341184.6	+	2	1610	c.1395C>T	c.(1393-1395)ttC>ttT	p.F465F		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	465					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GGGGCTGGTTCGACGGCACGC	0.637000													7	25					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65181297	65181297	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:65181297A>C	ENST00000310045.7	-	2	2052	c.579T>G	c.(577-579)ttT>ttG	p.F193L		NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	183						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				AGTTATATAAAAAGTCAAAGG	0.403000													28	51					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43922587	43922587	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43922587G>A	ENST00000329196.5	+	1	332	c.315G>A	c.(313-315)acG>acA	p.T105T	MAPT-AS1_ENST00000579244.1_RNA|MAPT-AS1_ENST00000579599.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	105						integral to membrane	aspartic-type endopeptidase activity										GCTTCCACACGAAAGGCTGGC	0.667000													8	30					0	0	1	0	0
P4HA1	5033	broad.mit.edu	37	10	74831805	74831805	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74831805G>A	ENST00000412021.2	-	5	640	c.307C>T	c.(307-309)Ctt>Ttt	p.L103F	P4HA1_ENST00000373008.2_Missense_Mutation_p.L103F|P4HA1_ENST00000263556.3_Missense_Mutation_p.L103F|RP11-344N10.2_ENST00000431293.2_RNA|P4HA1_ENST00000394890.2_Missense_Mutation_p.L103F|P4HA1_ENST00000307116.2_Missense_Mutation_p.L103F|P4HA1_ENST00000440381.1_Missense_Mutation_p.L103F	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	103						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ATATCCTTAAGGACCAGATTC	0.363000													63	206					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685641	100685641	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100685641C>T	ENST00000306151.4	+	3	11008	c.10944C>T	c.(10942-10944)acC>acT	p.T3648T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3648	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CATCGGTGACCATTTCTGAGG	0.488000													75	187					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6435711	6435711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6435711G>A	ENST00000449001.2	+	13	2040	c.1546G>A	c.(1546-1548)Gag>Aag	p.E516K	PLEKHG6_ENST00000396988.3_Missense_Mutation_p.E548K|PLEKHG6_ENST00000011684.7_Missense_Mutation_p.E548K|PLEKHG6_ENST00000304581.8_Missense_Mutation_p.E78K	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	548					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						GCCTTCCCTGGAGGGCTCTCA	0.607000													8	30					0	0	1	0	0
KDM4D	55693	broad.mit.edu	37	11	94731667	94731667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94731667C>T	ENST00000335080.5	+	3	1963	c.1131C>T	c.(1129-1131)ctC>ctT	p.L377L	KDM4D_ENST00000536741.1_Silent_p.L377L	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	377					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TGAGACAACTCCCTTCCCACT	0.632000													6	44					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428286	128428286	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:128428286G>A	ENST00000465342.2	+	2	1332	c.175G>A	c.(175-177)Ggg>Agg	p.G59R	CASC8_ENST00000502082.1_RNA|CASC8_ENST00000501396.1_RNA|CASC8_ENST00000523825.1_RNA|POU5F1B_ENST00000391675.1_Missense_Mutation_p.G59R			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	59						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						TGAGGTGTGGGGGATTCCCCC	0.667000													6	26					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57032176	57032176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57032176G>A	ENST00000262030.3	-	10	1571	c.1521C>T	c.(1519-1521)ttC>ttT	p.F507F	ATP5B_ENST00000552919.1_Silent_p.F496F	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	507					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCACCATATAGAAGGCCTGTT	0.458000													55	109					0	0	1	0	0
ATP1B4	23439	broad.mit.edu	37	X	119510247	119510247	+	Missense_Mutation	SNP	C	C	T	rs149447498		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:119510247C>T	ENST00000218008.3	+	6	829	c.772C>T	c.(772-774)Cgt>Tgt	p.R258C	ATP1B4_ENST00000361319.3_Missense_Mutation_p.R254C|ATP1B4_ENST00000539306.1_Missense_Mutation_p.R215C	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	258					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity	p.R254C(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						TGTAGGCTTTCGTCCTGAGCT	0.363000													28	11					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51758498	51758498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51758498G>A	ENST00000251076.5	-	30	7687	c.7400C>T	c.(7399-7401)cCt>cTt	p.P2467L	DMXL2_ENST00000543779.2_Missense_Mutation_p.P2468L|RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000449909.3_Missense_Mutation_p.P1831L	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2467						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		ATCAGACAAAGGAAGAAATGG	0.244000													28	84					0	0	1	0	0
RAD17	5884	broad.mit.edu	37	5	68677778	68677778	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:68677778G>A	ENST00000509734.1	+	6	1113	c.435G>A	c.(433-435)acG>acA	p.T145T	RAD17_ENST00000282891.6_Silent_p.T48T|RAD17_ENST00000380774.3_Silent_p.T145T|RAD17_ENST00000358030.2_5'UTR|RAD17_ENST00000354312.3_Silent_p.T134T|RAD17_ENST00000345306.6_Silent_p.T134T|RAD17_ENST00000305138.4_Silent_p.T134T|RAD17_ENST00000521422.1_5'UTR|RAD17_ENST00000504177.1_Intron|RAD17_ENST00000361732.2_Silent_p.T134T|RAD17_ENST00000354868.5_Silent_p.T134T			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	145					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		GAAAGACAACGACCTTAAAAA	0.333000								Other conserved DNA damage response genes					23	69					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603722	5603722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5603722C>T	ENST00000423158.3	+	2	593	c.381C>T	c.(379-381)ccC>ccT	p.P127P	NTF3_ENST00000331010.6_Silent_p.P114P|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	114					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						CCTTGGAGCCCCCGCCCTTGT	0.612000													21	71					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42490090	42490090	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42490090C>T	ENST00000545399.1	-	6	724	c.571G>A	c.(571-573)Ggg>Agg	p.G191R	ATP1A3_ENST00000302102.5_Missense_Mutation_p.G178R|ATP1A3_ENST00000602133.1_Missense_Mutation_p.G148R|ATP1A3_ENST00000543770.1_Missense_Mutation_p.G189R	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	178					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						ACCAGGTCCCCGACCACCACC	0.632000													41	130					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44371764	44371764	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44371764C>T	ENST00000371477.3	+	6	1057	c.758_splice	c.e6+1	p.S253_splice		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	253					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding	p.S253F(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAGCTAAGATCGTAAGTTGCC	0.398000													17	66					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328133	126328133	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126328133G>A	ENST00000394329.3	+	3	5419	c.5406G>A	c.(5404-5406)ttG>ttA	p.L1802L	FAT4_ENST00000335110.5_Silent_p.L100L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1802	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCAGGCGGTTGGACAGGGAAC	0.468000													56	131					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51378008	51378008	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51378008G>A	ENST00000325321.3	+	2	303	c.78G>A	c.(76-78)gtG>gtA	p.V26V	AC037199.1_ENST00000594218.1_Intron|KLK2_ENST00000391810.2_Intron|KLK2_ENST00000597509.1_3'UTR|KLK2_ENST00000358049.4_Silent_p.V26V			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	26	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		CTCGGATTGTGGGAGGCTGGG	0.622000			T	ETV4	prostate								13	55					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42941120	42941120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42941120G>A	ENST00000426333.2	-	15	1613	c.1316C>T	c.(1315-1317)cCt>cTt	p.P439L	EFTUD2_ENST00000402521.3_Missense_Mutation_p.P404L|EFTUD2_ENST00000591382.1_Missense_Mutation_p.P439L|EFTUD2_ENST00000592576.1_Missense_Mutation_p.P429L	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	439						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CTTTGGAGAAGGGATATGCTG	0.547000													22	29					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117993041	117993041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117993041C>T	ENST00000425217.1	-	9	1418	c.1364G>A	c.(1363-1365)cGg>cAg	p.R455Q	KSR2_ENST00000302438.5_Missense_Mutation_p.R181Q|KSR2_ENST00000339824.5_Missense_Mutation_p.R484Q|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	484					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGTGGCTTCCGTAGAGGGTT	0.502000													14	22					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21214532	21214532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21214532G>A	ENST00000574002.1	-	11	1495	c.1013C>T	c.(1012-1014)tCa>tTa	p.S338L	ZP2_ENST00000219593.4_Missense_Mutation_p.S338L|ZP2_ENST00000574091.1_Missense_Mutation_p.S338L|AF001550.7_ENST00000572747.1_RNA			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	338					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		CAGCTTGAGTGAAGCTAAGTA	0.463000													21	81					0	0	1	0	0
C1orf51	148523	broad.mit.edu	37	1	150255959	150255959	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150255959G>A	ENST00000290363.5	+	1	731	c.282G>A	c.(280-282)gcG>gcA	p.A94A	C1orf51_ENST00000469255.1_3'UTR|C1orf51_ENST00000369094.1_Silent_p.A6A|C1orf51_ENST00000369095.1_Silent_p.A94A	NM_144697.2	NP_653298.1	Q8N365	CA051_HUMAN	chromosome 1 open reading frame 51	94										endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(2)	10	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GATCTGGGGCGAAAAGATCAA	0.527000													48	118					0	0	1	0	0
LRRC40	55631	broad.mit.edu	37	1	70644631	70644631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70644631G>A	ENST00000370952.3	-	6	786	c.707C>T	c.(706-708)cCt>cTt	p.P236L		NM_017768.4	NP_060238.3	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	236										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(2)	27						CAATTCAGGAGGTATAGTTTC	0.313000													8	43					0	0	1	0	0
ZNF622	90441	broad.mit.edu	37	5	16463747	16463747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:16463747G>A	ENST00000308683.2	-	2	856	c.730C>T	c.(730-732)Cca>Tca	p.P244S		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	244						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						CCAAGGGGTGGGCCTTCCTCA	0.488000													69	229					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17922823	17922823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17922823C>T	ENST00000318683.6	+	3	1158	c.1011C>T	c.(1009-1011)taC>taT	p.Y337Y	B3GNT3_ENST00000595387.1_Silent_p.Y337Y	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	337					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						CCTGCTTCTACCGAGACCTGC	0.612000													69	170					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116037711	116037711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116037711G>A	ENST00000603594.1	+	7	926	c.605G>A	c.(604-606)gGg>gAg	p.G202E	VWA2_ENST00000392982.3_Missense_Mutation_p.G202E	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	202	VWFA 1.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GAGCCTAGAGGGCAGCACGTG	0.632000													11	20					0	0	1	0	0
CCNF	899	broad.mit.edu	37	16	2498891	2498891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2498891C>T	ENST00000397066.4	+	11	1218	c.1130C>T	c.(1129-1131)gCc>gTc	p.A377V		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	377	Cyclin N-terminal.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				ATCCGGGAGGCCGTATGGCTC	0.587000													34	110					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42695407	42695407	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42695407G>A	ENST00000358131.5	+	7	1548	c.1340G>A	c.(1339-1341)gGa>gAa	p.G447E	TOX2_ENST00000435864.2_Missense_Mutation_p.G343E|TOX2_ENST00000341197.3_Missense_Mutation_p.G465E|TOX2_ENST00000423191.1_Missense_Mutation_p.G423E|TOX2_ENST00000372999.1_Missense_Mutation_p.G423E	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	447	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGCAGCTCGGGATCCTGCTCA	0.632000													43	107					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084728	53084728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:53084728C>T	ENST00000276480.7	-	10	1376	c.693G>A	c.(691-693)ttG>ttA	p.L231L		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	231						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CAGGAACTTCCAATAGGTCTT	0.418000													18	69					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61414214	61414214	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61414214G>A	ENST00000395348.3	-	5	1206	c.570C>T	c.(568-570)ccC>ccT	p.P190P	SLC16A9_ENST00000395347.1_Silent_p.P190P	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	190					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						AAGATTGGAGGGGTCTCATCA	0.403000													43	112					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236205533	236205533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236205533G>A	ENST00000264187.6	-	4	894	c.812C>T	c.(811-813)aCc>aTc	p.T271I	NID1_ENST00000366595.3_Missense_Mutation_p.T271I	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	271					cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CACGCCATTGGTGGTGGCTGG	0.552000													95	216					0	0	1	0	0
ANGPTL7	10218	broad.mit.edu	37	1	11253760	11253760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11253760G>A	ENST00000376819.3	+	3	840	c.601G>A	c.(601-603)Gac>Aac	p.D201N	ANGPTL7_ENST00000476934.1_3'UTR|MTOR_ENST00000361445.4_Intron	NM_021146.2	NP_066969.1	O43827	ANGL7_HUMAN	angiopoietin-like 7	201	Fibrinogen C-terminal.				response to oxidative stress|signal transduction	extracellular region	receptor binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(2)|stomach(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.39e-06)|COAD - Colon adenocarcinoma(227;0.000244)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0487)		CATCCGTGGGGACTTCTGGCT	0.597000													26	58					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70446398	70446398	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70446398C>T	ENST00000373644.4	+	11	5547	c.5338C>T	c.(5338-5340)Cga>Tga	p.R1780*		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1780					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						ACCTATTCCCCGAATCAAGCG	0.468000													21	81					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75929446	75929446	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:75929446G>A	ENST00000321027.3	-	3	631	c.498C>T	c.(496-498)tcC>tcT	p.S166S	GCFC2_ENST00000470503.1_Silent_p.S166S|GCFC2_ENST00000541687.1_Silent_p.S166S|GCFC2_ENST00000409857.3_Silent_p.S166S	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	166					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										TACCAGAGATGGAGGAGGTAT	0.453000													57	119					0	0	1	0	0
TRAV41	28640	broad.mit.edu	37	14	22788875	22788875	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22788875C>T	ENST00000390468.1	+	0	88																											GGAGCAGAGTCCTCAGAACCT	0.418000													12	14					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107684286	107684286	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107684286C>T	ENST00000388781.3	-	29	4465	c.4382G>A	c.(4381-4383)aGg>aAg	p.R1461K	LAMB4_ENST00000205386.4_Missense_Mutation_p.R1461K|LAMB4_ENST00000388780.3_Missense_Mutation_p.R1461K	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1461	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CAGTTTTTCCCTCAGCTGTAA	0.323000													19	61					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6702545	6702545	+	Missense_Mutation	SNP	C	C	T	rs143642234		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6702545C>T	ENST00000245907.6	-	18	2383	c.2291G>A	c.(2290-2292)cGa>cAa	p.R764Q		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	764					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding	p.R764Q(1)		breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GAACTCACTTCGGGAAACGAT	0.537000													37	104					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768152	77768152	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77768152C>T	ENST00000521891.2	+	10	9443	c.8995C>T	c.(8995-8997)Caa>Taa	p.Q2999*	ZFHX4_ENST00000455469.2_Nonsense_Mutation_p.Q2954*|ZFHX4_ENST00000050961.6_Nonsense_Mutation_p.Q2954*|ZFHX4_ENST00000518282.1_Nonsense_Mutation_p.Q2973*	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2954						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CATGATCAATCAAGGCGGAAC	0.473000										HNSCC(33;0.089)			7	15					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37044568	37044568	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:37044568C>T	ENST00000282516.8	+	35	6727	c.6228C>T	c.(6226-6228)ctC>ctT	p.L2076L	NIPBL_ENST00000448238.2_Silent_p.L2076L	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2076					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TAATGAAGCTCATCATCAAAT	0.318000													7	79					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24373028	24373028	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24373028G>A	ENST00000005284.3	+	4	1994	c.792G>A	c.(790-792)atG>atA	p.M264I		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	264					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		ACATCTCGATGTTCACCCTCT	0.587000													23	113					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13719036	13719036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13719036C>T	ENST00000265104.4	-	72	12558	c.12454G>A	c.(12454-12456)Gat>Aat	p.D4152N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4152	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGTGGAGGATCGTTGGCAAAT	0.453000									Kartagener syndrome				25	77					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7983746	7983746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7983746C>T	ENST00000399413.3	+	2	667	c.427C>T	c.(427-429)Ctc>Ttc	p.L143F	ALOX12B_ENST00000319144.4_Intron																endometrium(2)	2						CCACTTAGGTCTCTGGGTCTC	0.597000											OREG0024153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	17					0	0	1	0	0
C6orf89	221477	broad.mit.edu	37	6	36882161	36882161	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36882161C>T	ENST00000480824.2	+	5	799	c.505C>T	c.(505-507)Ctg>Ttg	p.L169L	C6orf89_ENST00000359359.2_Silent_p.L63L|C6orf89_ENST00000355190.3_Silent_p.L176L|C6orf89_ENST00000510325.2_Silent_p.L63L|C6orf89_ENST00000373685.1_Silent_p.L169L			Q6UWU4	CF089_HUMAN	chromosome 6 open reading frame 89	169						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	15						GGTGATGCTCCTGGAAGACGC	0.542000													19	60					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103040467	103040467	+	Silent	SNP	G	G	A	rs11465694		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103040467G>A	ENST00000264260.2	+	4	856	c.267G>A	c.(265-267)tcG>tcA	p.S89S	IL18RAP_ENST00000409369.1_Intron	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	89					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						AACAACCTTCGAATGGAGATC	0.458000													22	52					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2604948	2604948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2604948G>A	ENST00000358864.1	+	17	2227	c.2212G>A	c.(2212-2214)Gag>Aag	p.E738K		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	738						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGTCCTCCAAGAGACCATTGA	0.483000													35	99					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283989	152283989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152283989C>T	ENST00000368799.1	-	3	3408	c.3373G>A	c.(3373-3375)Gaa>Aaa	p.E1125K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1125	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCAGACTGTTCATGAGTGCTC	0.607000									Ichthyosis				128	339					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6520098	6520098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6520098G>A	ENST00000377828.1	+	13	2625	c.2457G>A	c.(2455-2457)cgG>cgA	p.R819R	ESPN_ENST00000461727.1_Silent_p.R253R|ESPN_ENST00000416731.1_Silent_p.R253R|ESPN_ENST00000475228.1_3'UTR	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	819	Glu-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		AGCTGCGGCGGGAGAAGGAAC	0.637000													14	29					0	0	1	0	0
HGSNAT	138050	broad.mit.edu	37	8	43013755	43013755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:43013755C>T	ENST00000458501.2	+	3	356	c.356C>T	c.(355-357)cCa>cTa	p.P119L	HGSNAT_ENST00000379644.4_Missense_Mutation_p.P91L			Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	119					lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(6)	13	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			CCTCAGAGTCCAAAAGCAGGG	0.488000													33	85					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170177374	170177374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170177374G>A	ENST00000263816.3	-	2	385	c.100C>T	c.(100-102)Cgc>Tgc	p.R34C	LRP2_ENST00000443831.1_Missense_Mutation_p.R34C	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	34	LDL-receptor class A 1.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTTCCACAGCGAAAATGCGCA	0.413000													36	56					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20495414	20495414	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20495414G>A	ENST00000555186.1	+	0	617					NR_038836.1																						TGAGGAAAATGAATCCACAGC	0.393000													14	71					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10104455	10104455	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10104455C>T	ENST00000264828.3	-	17	1700	c.1615G>A	c.(1615-1617)Ggc>Agc	p.G539S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	539	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CCTGGGAGGCCCCGAGCTCCA	0.572000													8	125					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76587742	76587742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:76587742G>A	ENST00000307431.8	+	24	4053	c.3668G>A	c.(3667-3669)gGa>gAa	p.G1223E	RP11-58C22.1_ENST00000563764.1_Missense_Mutation_p.G32E|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.G1151E|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.G1175E|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.G1227E|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1224					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GATCATTCTGGAACAATAGAT	0.373000													4	19					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83224840	83224840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83224840G>A	ENST00000563800.1	-	5	2445	c.720C>T	c.(718-720)ttC>ttT	p.F240F	CPEB1_ENST00000398592.2_5'UTR|CPEB1_ENST00000261723.6_Silent_p.F216F|CPEB1_ENST00000568757.1_Silent_p.F138F|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000562019.1_Silent_p.F213F|CPEB1_ENST00000398591.2_Silent_p.F138F|CPEB1_ENST00000568128.1_Silent_p.F213F|CPEB1_ENST00000450751.2_Silent_p.F138F|CPEB1_ENST00000423133.2_Silent_p.F138F|CPEB1_ENST00000564522.1_Silent_p.F138F			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	213					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			ACAGAGACAGGAAGGGCAGAG	0.493000													6	32					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9510422	9510422	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9510422G>A	ENST00000246070.2	+	6	1290	c.798G>A	c.(796-798)caG>caA	p.Q266Q	LAMP5_ENST00000427562.2_Silent_p.Q222Q	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	266						integral to membrane		p.Q266H(1)									CTGCCAACCAGGTGCAGATCC	0.547000													13	71					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21588586	21588586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21588586C>T	ENST00000392288.2	+	3	290	c.181C>T	c.(181-183)Ctg>Ttg	p.L61L	CTD-2561J22.3_ENST00000600810.1_Silent_p.L42L|ZNF493_ENST00000339914.6_Silent_p.L62L|ZNF493_ENST00000594390.1_Silent_p.L61L|ZNF493_ENST00000596302.1_Silent_p.L62L|ZNF493_ENST00000355504.4_Intron	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						TAAGCCAGATCTGGTCACCTG	0.408000													42	91					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69000001	69000001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:69000001G>A	ENST00000288368.4	+	19	2347	c.2070G>A	c.(2068-2070)caG>caA	p.Q690Q	RP11-403D15.2_ENST00000526901.1_RNA|PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	690	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TTGGCTTCCAGATCCGGGGAT	0.443000													40	148					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161022284	161022284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161022284C>T	ENST00000368013.3	-	8	1206	c.886G>A	c.(886-888)Ggt>Agt	p.G296S	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.G296S|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.G119S	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	296					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CCAGAGCGACCTAAATTGAAG	0.547000													95	243					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7636110	7636110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7636110C>T	ENST00000359156.4	-	12	3143	c.2941G>A	c.(2941-2943)Gaa>Aaa	p.E981K	CD163_ENST00000539632.1_5'UTR|CD163_ENST00000541972.1_Missense_Mutation_p.E969K|CD163_ENST00000396620.3_Missense_Mutation_p.E1014K|CD163_ENST00000432237.2_Missense_Mutation_p.E981K	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	981	SRCR 9.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AACTCTGCTTCTTTGAATGCT	0.522000													45	91					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86518880	86518880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:86518880G>A	ENST00000297814.2	-	4	696	c.553C>T	c.(553-555)Ctt>Ttt	p.L185F	KIF27_ENST00000334204.2_Missense_Mutation_p.L185F|KIF27_ENST00000413982.1_Missense_Mutation_p.L185F	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	185	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						ATCTCCAAAAGACTCATCACT	0.408000													99	185					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81585035	81585035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81585035C>T	ENST00000394660.2	+	12	1919	c.1559C>T	c.(1558-1560)tCc>tTc	p.S520F	IL16_ENST00000302987.4_Missense_Mutation_p.S520F	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	520					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						ATGTCTGGGTCCCCAGGGGGA	0.612000													9	69					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56520202	56520202	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56520202G>A	ENST00000390649.3	+	3	491	c.491G>A	c.(490-492)aGc>aAc	p.S164N		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	164						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CAAGGACCAAGCAAGGAAAAA	0.468000													4	19					0	0	1	0	0
TNNI3K	51086	broad.mit.edu	37	1	75005954	75005954	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75005954G>A	ENST00000370891.2	+	26	2707	c.2691G>A	c.(2689-2691)gaG>gaA	p.E897E	TNNI3K_ENST00000326637.3_Silent_p.E796E|FPGT-TNNI3K_ENST00000557284.1_Silent_p.E897E|TNNI3K_ENST00000465473.1_3'UTR	NM_001112808.2	NP_001106279.1			TNNI3 interacting kinase											cervix(1)|endometrium(3)|kidney(5)|large_intestine(21)|lung(31)|ovary(4)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	76						TGTCTTTGGAGGAGATGAAAA	0.358000													20	57					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189964865	189964865	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189964865C>T	ENST00000374866.3	-	4	611	c.336_splice	c.e4-1	p.G113_splice		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	113					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCTTTTGTCCCTGTGACATT	0.328000													23	75					0	0	1	0	0
OSER1	51526	broad.mit.edu	37	20	42825913	42825913	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42825913G>A	ENST00000372970.2	-	6	838	c.658C>T	c.(658-660)Ctg>Ttg	p.L220L	OSER1_ENST00000255174.2_Silent_p.L220L					oxidative stress responsive serine-rich 1																		ACACTCTGCAGGCCTGAAAAG	0.522000													11	80					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628377	173628377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173628377G>A	ENST00000333279.2	-	2	241	c.181C>T	c.(181-183)Cct>Tct	p.P61S		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	77										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						TCATGATGAGGATTCTCAGGA	0.473000													24	50					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272724	81272724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81272724G>A	ENST00000520547.2	+	1	368	c.319G>A	c.(319-321)Gag>Aag	p.E107K		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	107					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			GGACAGCGGGGAGGTACCAGA	0.532000													9	98					0	0	1	0	0
CD99	4267	broad.mit.edu	37	X	2632473	2632473	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:2632473C>T	ENST00000381192.3	+	2	260	c.78C>T	c.(76-78)ttC>ttT	p.F26F	CD99_ENST00000381187.3_Silent_p.F26F|CD99_ENST00000482405.2_3'UTR|CD99_ENST00000381184.1_Silent_p.F26F	NM_001277710.1|NM_002414.3	NP_001264639.1|NP_002405.1	P14209	CD99_HUMAN	CD99 molecule	26					cell adhesion	cytoplasm|integral to plasma membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	11						ATGGTGGTTTCGATTTATCCG	0.294000													54	227					0	0	1	0	0
NXPE3	91775	broad.mit.edu	37	3	101540472	101540472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:101540472C>T	ENST00000422132.1	+	5	1551	c.1354C>T	c.(1354-1356)Cct>Tct	p.P452S	NXPE3_ENST00000491511.1_Missense_Mutation_p.P452S|NXPE3_ENST00000273347.5_Missense_Mutation_p.P452S|NXPE3_ENST00000477909.1_Missense_Mutation_p.P452S					neurexophilin and PC-esterase domain family, member 3																		CAGCACCTTCCCTTTGGAAGT	0.547000													20	58					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51792266	51792266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51792266G>A	ENST00000251076.5	-	18	3442	c.3155C>T	c.(3154-3156)cCt>cTt	p.P1052L	DMXL2_ENST00000543779.2_Missense_Mutation_p.P1052L|DMXL2_ENST00000449909.3_Intron	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1052						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		ATTCATCAAAGGCCATCTCTT	0.413000													25	85					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167240194	167240194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167240194C>T	ENST00000308378.3	-	12	1932	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K	WDR49_ENST00000453925.2_Intron|WDR49_ENST00000479765.1_Intron|WDR49_ENST00000476376.1_Missense_Mutation_p.E368K	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	543										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						AAAGAAATTTCCTTTTGAATC	0.318000													49	28					0	0	1	0	0
IFNG	3458	broad.mit.edu	37	12	68552030	68552030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:68552030G>A	ENST00000229135.3	-	2	255	c.124C>T	c.(124-126)Cat>Tat	p.H42Y	IFNG-AS1_ENST00000536914.1_RNA	NM_000619.2	NP_000610.2	P01579	IFNG_HUMAN	interferon, gamma	42					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	ACATCTGAATGACCTGCATTC	0.313000													12	27					0	0	1	0	0
LMAN2L	81562	broad.mit.edu	37	2	97377690	97377690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:97377690G>A	ENST00000264963.4	-	5	602	c.580C>T	c.(580-582)Cct>Tct	p.P194S	LMAN2L_ENST00000537039.1_Missense_Mutation_p.P56S|LMAN2L_ENST00000377079.4_Missense_Mutation_p.P205S|LMAN2L_ENST00000426463.2_Missense_Mutation_p.P60S|LMAN2L_ENST00000534882.1_Missense_Mutation_p.P49S	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	194	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						AGCTCTGTAGGCCGCCCATCC	0.557000													23	49					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76511007	76511007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76511007C>T	ENST00000389840.5	-	26	4074	c.3950G>A	c.(3949-3951)aGg>aAg	p.R1317K	DNAH17_ENST00000585328.1_Missense_Mutation_p.R1318K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTCCAAAGACCTCATGTCCTT	0.507000													41	97					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31124949	31124949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31124949C>T	ENST00000304166.4	+	9	850	c.561C>T	c.(559-561)ttC>ttT	p.F187F	ADCYAP1R1_ENST00000409363.1_Silent_p.F166F|ADCYAP1R1_ENST00000409489.1_Silent_p.F187F|ADCYAP1R1_ENST00000396211.2_Silent_p.F187F	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	187					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						CACGCAACTTCATCCACATGA	0.532000													33	103					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83931724	83931724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83931724G>A	ENST00000345382.2	-	4	2364	c.2279C>T	c.(2278-2280)cCc>cTc	p.P760L	BNC1_ENST00000569704.1_Missense_Mutation_p.P753L|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	760					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						CCTGCGGGAGGGAAAGGTAGC	0.428000													20	33					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52940209	52940209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52940209C>T	ENST00000267119.5	-	7	1255	c.1186G>A	c.(1186-1188)Gag>Aag	p.E396K		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	396	Coil 2.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CCCTCCAGCTCGTCCAGCTTG	0.632000													19	57					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7705860	7705860	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7705860C>T	ENST00000441779.2	+	6	470	c.433C>T	c.(433-435)Cac>Tac	p.H145Y	STXBP2_ENST00000221283.5_Missense_Mutation_p.H134Y|STXBP2_ENST00000414284.2_Missense_Mutation_p.H131Y|CTD-3214H19.4_ENST00000595866.1_3'UTR	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	134					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						GAAGGAGATTCACCTTGCCTT	0.627000													36	59					0	0	1	0	0
TMEM176A	55365	broad.mit.edu	37	7	150499314	150499314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150499314C>T	ENST00000484928.1	+	3	767	c.186C>T	c.(184-186)atC>atT	p.I62I	TMEM176A_ENST00000004103.3_Silent_p.I62I|TMEM176A_ENST00000461345.1_Silent_p.I3I			Q96HP8	T176A_HUMAN	transmembrane protein 176A	62						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGATGCAGATCGTGCTGGGGA	0.562000													17	48					0	0	1	0	0
TRIM8	81603	broad.mit.edu	37	10	104404680	104404680	+	Silent	SNP	C	C	T	rs11550359		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104404680C>T	ENST00000302424.6	+	1	428	c.306C>T	c.(304-306)ccC>ccT	p.P102P		NM_030912.2	NP_112174.2	Q9BZR9	TRIM8_HUMAN	tripartite motif containing 8	102						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCCCGCTGCCCGCGCAGAAGG	0.711000													4	10					0	0	1	0	0
ZNF587	84914	broad.mit.edu	37	19	58367558	58367558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58367558C>T	ENST00000339656.5	+	2	302	c.120C>T	c.(118-120)taC>taT	p.Y40Y	ZNF814_ENST00000596604.1_Intron|CTD-2583A14.10_ENST00000598031.1_Silent_p.Y40Y|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597652.1_Intron|ZNF587B_ENST00000316462.4_3'UTR|ZNF587_ENST00000423137.1_Silent_p.Y39Y|ZNF587_ENST00000419854.1_5'UTR|ZNF814_ENST00000597832.1_Intron	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		GGTGCTTGTACCGTGATGTGA	0.498000													16	91					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922012	24922012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922012C>T	ENST00000329468.2	+	1	1472	c.998C>T	c.(997-999)cCa>cTa	p.P333L		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ATGTCGATTCCATTGCTGCTG	0.577000													25	37					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48921756	48921756	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48921756G>A	ENST00000310194.1	+	2	950	c.950G>A	c.(949-951)tGg>tAg	p.W317*	OR8S1_ENST00000551654.1_3'UTR	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	317					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						CAGGCCAGATGGAAGAGACCA	0.577000													14	50					0	0	1	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047788	46047788	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46047788C>T	ENST00000397911.3	+	1	749	c.700C>T	c.(700-702)Ctc>Ttc	p.L234F	KRTAP10-9_ENST00000484861.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198690.2	NP_941963.2	P60411	KR109_HUMAN	keratin associated protein 10-9	234	25 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9						TGTGTCCCTCCTCTGCCGCCC	0.687000													32	209					0	0	1	0	0
BAHD1	22893	broad.mit.edu	37	15	40754416	40754416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40754416C>T	ENST00000561234.1	+	3	1994	c.1735C>T	c.(1735-1737)Cct>Tct	p.P579S	BAHD1_ENST00000416165.1_Missense_Mutation_p.P580S|BAHD1_ENST00000560846.1_Missense_Mutation_p.P580S			Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	580	Arg-rich.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(3)|lung(10)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	28		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		GCGCCCACGCCCTCGCCGCCG	0.647000													49	109					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072095	17072095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17072095G>A	ENST00000359963.3	-	1	1605	c.1346C>T	c.(1345-1347)cCt>cTt	p.P449L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	449					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CAAAGTTTTAGGAAGATACTT	0.498000													35	116					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2041159	2041159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2041159G>A	ENST00000250896.3	-	12	1234	c.990C>T	c.(988-990)ccC>ccT	p.P330P	MKNK2_ENST00000588014.1_Silent_p.P74P|MKNK2_ENST00000591588.1_Silent_p.P74P|MKNK2_ENST00000591601.1_Silent_p.P330P|MKNK2_ENST00000591142.1_Silent_p.P74P|MKNK2_ENST00000541165.1_Silent_p.P199P|MKNK2_ENST00000309340.7_Silent_p.P330P	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	330	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCCTTGTCGGGGAACTCGT	0.597000													38	86					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14939133	14939133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14939133C>T	ENST00000285046.5	+	5	2976	c.2866C>T	c.(2866-2868)Cat>Tat	p.H956Y	FGD5_ENST00000476851.1_3'UTR|FGD5_ENST00000543601.1_Missense_Mutation_p.H715Y	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	956	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCACGACCTTCATCAAGGCAT	0.587000													3	12					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2413244	2413244	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2413244G>A	ENST00000202625.2	+	13	2137	c.2076G>A	c.(2074-2076)ccG>ccA	p.P692P	TGM6_ENST00000381423.1_3'UTR	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	692					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CTCACTTCCCGGACATCAAGG	0.592000													38	117					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141794427	141794427	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141794427G>A	ENST00000475668.2	+	62	7368	c.7314G>A	c.(7312-7314)atG>atA	p.M2438I	MGAM_ENST00000549489.2_Missense_Mutation_p.M1542I			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1542					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CAGGCATGATGGAGTTCAGCC	0.552000													27	69					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48745123	48745123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48745123G>A	ENST00000427699.1	+	12	1720	c.1640G>A	c.(1639-1641)aGg>aAg	p.R547K	ABCC3_ENST00000285238.8_Intron	NM_001144070.1	NP_001137542.1	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	547	ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TTCCTGGTGAGGCTTGGCACA	0.662000													8	36					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075737	145075737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145075737G>A	ENST00000369359.4	-	1	164	c.126C>T	c.(124-126)tcC>tcT	p.S42S	PDE4DIP_ENST00000369345.4_Silent_p.S42S|PDE4DIP_ENST00000369348.3_Silent_p.S42S|PDE4DIP_ENST00000530740.1_Silent_p.S42S			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTGCCGTGGGGACTGAGGGG	0.736000			T	PDGFRB	MPD								12	109					0	0	1	0	0
SLC25A23	79085	broad.mit.edu	37	19	6452337	6452337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6452337G>A	ENST00000301454.4	-	8	1163	c.1057C>T	c.(1057-1059)Ctg>Ttg	p.L353L	SLC25A23_ENST00000414491.2_Intron|SLC25A23_ENST00000334510.5_Silent_p.L353L	NM_024103.2	NP_077008.2	Q9BV35	SCMC3_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	353					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|pancreas(1)|skin(1)	17						TAGACGGCCAGGTCGATGCCC	0.667000													3	28					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45782899	45782899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45782899C>T	ENST00000357450.4	-	11	1758	c.1759G>A	c.(1759-1761)Gag>Aag	p.E587K	SMC1B_ENST00000404354.3_Missense_Mutation_p.E587K	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	587	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCTTTAAGCTCCCTTAGTCTT	0.328000													26	100					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683038	71683038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71683038C>T	ENST00000393524.2	-	17	4259	c.3526G>A	c.(3526-3528)Ggc>Agc	p.G1176S	PHLPP2_ENST00000360429.3_Intron|PHLPP2_ENST00000540628.1_Intron|PHLPP2_ENST00000568954.1_Missense_Mutation_p.G1243S|PHLPP2_ENST00000356272.3_Missense_Mutation_p.G1243S|PHLPP2_ENST00000567016.1_Missense_Mutation_p.G1278S			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1243						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						ACAATAGAGCCATTGGAGAGT	0.522000													6	97					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699252	43699252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43699252G>A	ENST00000405312.3	-	4	1120	c.883C>T	c.(883-885)Ctc>Ttc	p.L295F	PSG4_ENST00000433626.2_Missense_Mutation_p.L202F|PSG4_ENST00000244295.9_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	295	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				GGTAGAATGAGGATCCTGTTT	0.478000													27	320					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34018600	34018600	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34018600G>A	ENST00000389232.4	+	46	6996	c.6926G>A	c.(6925-6927)gGa>gAa	p.G2309E	RYR3_ENST00000415757.3_Missense_Mutation_p.G2309E	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2309	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATCCAGACAGGAAAGGGGGAA	0.557000													3	19					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53686563	53686563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:53686563G>A	ENST00000262135.4	-	15	2129	c.2036C>T	c.(2035-2037)aCc>aTc	p.T679I	RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.T679I|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.T679I|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.T679I	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	679	C2 1.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				GACCTCAAGGGTGATAGTATT	0.363000													15	73					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95056388	95056388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95056388G>A	ENST00000329597.7	+	4	840	c.630G>A	c.(628-630)gaG>gaA	p.E210E	SERPINA5_ENST00000553780.1_Silent_p.E210E|SERPINA5_ENST00000554866.1_Silent_p.E210E|SERPINA5_ENST00000554276.1_Silent_p.E210E	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	210					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CTAAGTGGGAGACAAGCTTCA	0.433000													15	21					0	0	1	0	0
IRF2	3660	broad.mit.edu	37	4	185310027	185310027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:185310027G>A	ENST00000393593.3	-	9	1142	c.935C>T	c.(934-936)cCc>cTc	p.P312L		NM_002199.3	NP_002190.2	P14316	IRF2_HUMAN	interferon regulatory factor 2	312					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	22		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		GGAAGAAAGGGGGAGGTCTTG	0.587000													36	72					0	0	1	0	0
ITPK1	3705	broad.mit.edu	37	14	93483113	93483113	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93483113G>A	ENST00000267615.6	-	4	327	c.154C>T	c.(154-156)Ccc>Tcc	p.P52S	ITPK1_ENST00000354313.3_Missense_Mutation_p.P52S|ITPK1_ENST00000555495.1_5'UTR|ITPK1_ENST00000556603.2_Missense_Mutation_p.P52S|ITPK1_ENST00000556954.1_5'UTR			Q13572	ITPK1_HUMAN	inositol-tetrakisphosphate 1-kinase	52					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)	11		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		ACGTCCAGGGGGCCCTGCTCC	0.572000													22	80					0	0	1	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090588	238090588	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:238090588G>A	ENST00000450451.1	+	0	2094					NR_027247.2																						GCATTGTCAGGGACTCTGGAG	0.612000													9	30					0	0	1	0	0
NSMCE4A	54780	broad.mit.edu	37	10	123730536	123730536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123730536G>A	ENST00000369023.3	-	3	470	c.419C>T	c.(418-420)gCt>gTt	p.A140V	NSMCE4A_ENST00000369017.5_Missense_Mutation_p.A140V|NSMCE4A_ENST00000538652.1_5'UTR|NSMCE4A_ENST00000489266.1_5'UTR	NM_001167865.1|NM_017615.2	NP_001161337.1|NP_060085.2	Q9NXX6	NSE4A_HUMAN	non-SMC element 4 homolog A (S. cerevisiae)	140										breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	6		all_neural(114;0.138)|Glioma(114;0.222)				CAAATCTGAAGCCAAAACAAG	0.393000													17	42					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142021316	142021316	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142021316C>T	ENST00000390381.3	+	0	605																											AATGTGAGCACCTTGGAGCTG	0.522000													14	71					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46916019	46916019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46916019C>T	ENST00000307522.3	-	1	822	c.49G>A	c.(49-51)Gtc>Atc	p.V17I		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	17						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		gccagcctgacctcccggggg	0.602000													8	59					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62782276	62782276	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62782276G>A	ENST00000336232.2	-	2	290	c.155C>T	c.(154-156)cCc>cTc	p.P52L	SLC22A8_ENST00000311438.8_Missense_Mutation_p.P52L|SLC22A8_ENST00000545207.1_Intron|SLC22A8_ENST00000535878.1_Intron|SLC22A8_ENST00000430500.2_Missense_Mutation_p.P52L	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	52					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						GGCATTGTGGGGCGGGCGACA	0.627000													97	161					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31477646	31477646	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31477646C>T	ENST00000408912.3	+	8	2846	c.2529C>T	c.(2527-2529)ccC>ccT	p.P843P	ARMC5_ENST00000563544.1_Silent_p.P748P|ARMC5_ENST00000268314.4_Silent_p.P748P|ARMC5_ENST00000457010.2_3'UTR|ARMC5_ENST00000412665.2_Silent_p.P392P|ARMC5_ENST00000538189.1_Silent_p.P780P			Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	748							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						TCCCAGCTCCCGACCTGCACT	0.667000													11	27					0	0	1	0	0
OR4D10	390197	broad.mit.edu	37	11	59245655	59245655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59245655C>T	ENST00000530162.1	+	1	810	c.753C>T	c.(751-753)ttC>ttT	p.F251F		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F249L(1)		NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCCTGCATTTCGTGCCCTGCA	0.547000													77	186					0	0	1	0	0
SPRR2D	6703	broad.mit.edu	37	1	153012740	153012740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153012740G>A	ENST00000368757.1	-	2	363	c.83C>T	c.(82-84)cCa>cTa	p.P28L	SPRR2D_ENST00000368758.3_Missense_Mutation_p.P28L|SPRR2D_ENST00000360379.3_Missense_Mutation_p.P28L|SPRR2D_ENST00000368756.1_Missense_Mutation_p.P28L			P22532	SPR2D_HUMAN	small proline-rich protein 2D	28	3 X 9 AA tandem repeats of P-K-C-P-[EQ]- P-C-P-[PS].				keratinization	cornified envelope|cytoplasm				endometrium(1)|skin(1)	2	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTTCGGGGGTGGACATGGCTC	0.607000													51	138					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103467999	103467999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103467999C>T	ENST00000358392.2	-	23	2435	c.2118G>A	c.(2116-2118)ggG>ggA	p.G706G	COL11A1_ENST00000512756.1_Silent_p.G578G|COL11A1_ENST00000461720.1_5'UTR|COL11A1_ENST00000353414.4_Silent_p.G655G|COL11A1_ENST00000370096.3_Silent_p.G694G	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	694	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTCCTGGATTCCCTTGTTGAC	0.423000													5	9					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55862776	55862776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55862776G>A	ENST00000422046.2	-	2	441	c.160C>T	c.(160-162)Cct>Tct	p.P54S	CES1_ENST00000360526.3_Missense_Mutation_p.P55S|CES1_ENST00000361503.4_Missense_Mutation_p.P54S			P23141	EST1_HUMAN	carboxylesterase 1	54					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	TTGGCAAAAGGGATTCCCAGG	0.557000													7	38					0	0	1	0	0
TBC1D3F	84218	broad.mit.edu	37	17	36288274	36288274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:36288274G>A	ENST00000539424.1	+	2	1785	c.120G>A	c.(118-120)atG>atA	p.M40I	TBC1D3F_ENST00000327454.6_Missense_Mutation_p.M120I|TBC1D3F_ENST00000378174.5_Missense_Mutation_p.M120I|TBC1D3F_ENST00000505415.1_Missense_Mutation_p.M120I			A6NER0	TBC3F_HUMAN	TBC1 domain family, member 3F	120						intracellular	Rab GTPase activator activity			liver(1)|pancreas(1)	2						CTGAGGAAATGAAGTTGAAAA	0.557000													65	608					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056224	9056224	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9056224C>T	ENST00000397910.4	-	3	31425	c.31222G>A	c.(31222-31224)Gga>Aga	p.G10408R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10410	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCACTGTTCCCAGCTCAACG	0.478000													45	202					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201485454	201485454	+	Missense_Mutation	SNP	G	G	A	rs148848561		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:201485454G>A	ENST00000374700.2	+	17	2027	c.1786G>A	c.(1786-1788)Gag>Aag	p.E596K	AOX1_ENST00000485106.1_Intron	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	596					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TGCCACGGGGGAGGCCATCTA	0.458000													17	45					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2297430	2297430	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2297430C>T	ENST00000222990.3	-	8	966	c.924G>A	c.(922-924)caG>caA	p.Q308Q		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	308					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding	p.Q308H(1)		breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CGTTCTCTTCCTGCTTACCCT	0.612000													67	171					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182822450	182822450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:182822450C>T	ENST00000367549.3	+	5	484	c.374C>T	c.(373-375)tCt>tTt	p.S125F		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	125	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						GAAAATAATTCTGAGGTAGGG	0.393000													28	75					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5040786	5040786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:5040786G>A	ENST00000251170.7	+	5	544	c.364G>A	c.(364-366)Gac>Aac	p.D122N		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	122	PRELI/MSF1.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						TGAGAATGAAGACTGGACTTG	0.572000													10	37					0	0	1	0	0
GNLY	10578	broad.mit.edu	37	2	85921566	85921566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:85921566C>T	ENST00000263863.4	+	1	153	c.25C>T	c.(25-27)Ctt>Ttt	p.L9F	GNLY_ENST00000524600.1_Missense_Mutation_p.L9F|GNLY_ENST00000409696.3_5'UTR|GNLY_ENST00000533041.1_3'UTR	NM_006433.3	NP_006424.2	P22749	GNLY_HUMAN	granulysin	9					cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						CCTCCTGCTCCTTGCAGCCAT	0.617000													25	56					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6965357	6965357	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6965357G>A	ENST00000389658.3	-	50	7218	c.7125C>T	c.(7123-7125)acC>acT	p.T2375T		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2375	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGTCAAAAGGGTAATGGGTC	0.463000													40	93					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129284780	129284780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129284780G>A	ENST00000393239.1	-	24	4450	c.4272C>T	c.(4270-4272)atC>atT	p.I1424I	PLXND1_ENST00000324093.4_Silent_p.I1424I			Q9Y4D7	PLXD1_HUMAN	plexin D1	1424					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GGACAAAGACGATGAGGAAGT	0.557000													5	53					0	0	1	0	0
TET2	54790	broad.mit.edu	37	4	106155373	106155373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:106155373G>A	ENST00000513237.1	+	3	1134	c.337G>A	c.(337-339)Gga>Aga	p.G113R	TET2_ENST00000545826.1_Missense_Mutation_p.G92R|TET2_ENST00000394764.1_Missense_Mutation_p.G92R|TET2_ENST00000413648.2_Missense_Mutation_p.G92R|TET2_ENST00000380013.4_Missense_Mutation_p.G92R|TET2_ENST00000305737.2_Missense_Mutation_p.G92R|TET2_ENST00000540549.1_Missense_Mutation_p.G92R			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	92					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TTTGCAAAATGGAGGAATAAA	0.403000			"""Mis N, F"""		MDS								28	72					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254667	51254667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:51254667C>T	ENST00000404971.1	-	2	2084	c.745G>A	c.(745-747)Ggc>Agc	p.G249S	NRXN1_ENST00000405581.1_Missense_Mutation_p.G249S|NRXN1_ENST00000402717.3_Missense_Mutation_p.G249S|NRXN1_ENST00000401669.2_Missense_Mutation_p.G249S|NRXN1_ENST00000406316.2_Missense_Mutation_p.G249S|NRXN1_ENST00000405472.3_Missense_Mutation_p.G249S|NRXN1_ENST00000406859.3_Missense_Mutation_p.G249S	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	249	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCGCGGAAGCCGGTTCGCGAG	0.756000													9	28					0	0	1	0	0
LOC344967	344967	broad.mit.edu	37	4	40045360	40045360	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40045360G>A	ENST00000381811.2	-	0	789					NR_027277.1																						CACAACAGGAGGCTCTTCGAG	0.577000													12	17					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8485972	8485972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8485972C>T	ENST00000381196.4	-	25	3388	c.2845G>A	c.(2845-2847)Ggc>Agc	p.G949S	PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.G949S|PTPRD_ENST00000360074.4_Missense_Mutation_p.G936S|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.G927S|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.G949S|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000397606.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	949	Fibronectin type-III 7.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GTGATAATGCCATTTCTCTCT	0.478000										TSP Lung(15;0.13)			10	91					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20554523	20554523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20554523C>T	ENST00000329697.6	-	11	1511	c.1343G>A	c.(1342-1344)gGa>gAa	p.G448E	ACSM2B_ENST00000565322.1_Missense_Mutation_p.G369E|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G448E|ACSM2B_ENST00000565232.1_Missense_Mutation_p.G448E	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	448					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						ATCTTTGATTCCCCGGTCTCC	0.488000													15	309					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674254	4674254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4674254C>T	ENST00000396952.5	+	2	1148	c.498C>T	c.(496-498)atC>atT	p.I166I	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I165M(2)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTCTTCATCAAGCAGCTGC	0.552000													41	127					0	0	1	0	0
HIST1H3I	8354	broad.mit.edu	37	6	27839863	27839863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:27839863C>T	ENST00000328488.2	-	1	236	c.231G>A	c.(229-231)caG>caA	p.Q77Q		NM_003533.2	NP_003524.1	P68431	H31_HUMAN	histone cluster 1, H3i	77					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TCTTAAAGTCCTGTGCGATCT	0.612000													19	128					0	0	1	0	0
TRIB3	57761	broad.mit.edu	37	20	377122	377122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:377122C>T	ENST00000217233.3	+	4	1418	c.865C>T	c.(865-867)Cgc>Tgc	p.R289C	TRIB3_ENST00000422053.2_Missense_Mutation_p.R316C	NM_021158.3	NP_066981.2	Q96RU7	TRIB3_HUMAN	tribbles pseudokinase 3	289	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|skin(1)	21		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GGCCCCTGCCCGCTGTCTGGT	0.692000													36	85					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8404586	8404586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8404586C>T	ENST00000381196.4	-	33	4704	c.4161G>A	c.(4159-4161)gcG>gcA	p.A1387A	PTPRD_ENST00000397611.3_Silent_p.A977A|PTPRD_ENST00000397617.3_Silent_p.A980A|PTPRD_ENST00000540109.1_Silent_p.A1387A|PTPRD_ENST00000360074.4_Silent_p.A1374A|PTPRD_ENST00000537002.1_Silent_p.A977A|PTPRD_ENST00000358503.5_Silent_p.A1365A|PTPRD_ENST00000486161.1_Silent_p.A980A|PTPRD_ENST00000356435.5_Silent_p.A1387A|PTPRD_ENST00000355233.5_Silent_p.A981A|PTPRD_ENST00000397606.3_Silent_p.A980A	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1387	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CGATTACATTCGCGTATCTAT	0.378000										TSP Lung(15;0.13)			13	42					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206610476	206610476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206610476G>A	ENST00000360409.3	+	10	2439	c.1648G>A	c.(1648-1650)Gaa>Aaa	p.E550K	NRP2_ENST00000357118.4_Missense_Mutation_p.E550K|NRP2_ENST00000540841.1_Missense_Mutation_p.E550K|NRP2_ENST00000540178.1_Missense_Mutation_p.E550K|NRP2_ENST00000357785.5_Missense_Mutation_p.E550K|NRP2_ENST00000272849.3_Missense_Mutation_p.E550K|NRP2_ENST00000412873.2_Missense_Mutation_p.E550K	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	550	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GCAGCTGTTCGAAGGGAACAT	0.607000													12	28					0	0	1	0	0
SAMD8	142891	broad.mit.edu	37	10	76910586	76910586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:76910586C>T	ENST00000542569.1	+	2	403	c.300C>T	c.(298-300)ttC>ttT	p.F100F	SAMD8_ENST00000372690.3_Silent_p.F163F|SAMD8_ENST00000372687.3_Silent_p.F100F	NM_001174156.1|NM_144660.2	NP_001167627.1|NP_653261.1	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	100					sphingomyelin biosynthetic process	integral to membrane				NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	12	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TGACCCCTTTCATCAGTGCTC	0.448000													32	86					0	0	1	0	0
GZMA	3001	broad.mit.edu	37	5	54403991	54403991	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54403991C>T	ENST00000274306.6	+	4	431	c.396C>T	c.(394-396)atC>atT	p.I132I		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	132	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				ATGTGACTATCCTTCATCTAC	0.373000													9	43					0	0	1	0	0
CLDN12	9069	broad.mit.edu	37	7	90042413	90042413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:90042413C>T	ENST00000535571.1	+	2	732	c.423C>T	c.(421-423)ttC>ttT	p.F141F	CLDN12_ENST00000394605.2_Silent_p.F141F|CLDN12_ENST00000287916.4_Silent_p.F141F	NM_001185072.2	NP_001172001.1	P56749	CLD12_HUMAN	claudin 12	141					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			breast(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)	15						TGCTATTTTTCCTGGCAGGTA	0.493000													50	114					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135482015	135482015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135482015G>A	ENST00000394143.1	+	21	8606	c.8315G>A	c.(8314-8316)cGa>cAa	p.R2772Q	GPR112_ENST00000370652.1_Missense_Mutation_p.R2772Q|GPR112_ENST00000394141.1_Missense_Mutation_p.R2567Q|GPR112_ENST00000412101.1_Missense_Mutation_p.R2567Q|GPR112_ENST00000287534.4_Missense_Mutation_p.R2525Q	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2772					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AGCAAACTTCGAAAAGATTAT	0.318000													26	22					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045045	87045045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87045045G>A	ENST00000370563.3	+	13	2173	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	711						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AGGGGAAATTGAAGCAAACCC	0.413000													27	48					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100261751	100261751	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100261751C>T	ENST00000515683.1	-	0	1296					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	TAGCTCCTTTCCACGTGCGTC	0.438000													69	203					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141243024	141243024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141243024C>T	ENST00000389484.3	-	59	10284	c.9313G>A	c.(9313-9315)Gac>Aac	p.D3105N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3105					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTCTGTGTCAGACCAATAG	0.393000										TSP Lung(27;0.18)			29	56					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56271348	56271348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56271348C>T	ENST00000225371.5	+	5	599	c.489C>T	c.(487-489)tcC>tcT	p.S163S		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	163				S -> C (in Ref. 3; AA sequence).	hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						TAGGGGCCTCCAACCAGGCTC	0.667000													16	41					0	0	1	0	0
ALG1	56052	broad.mit.edu	37	16	5125427	5125427	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:5125427C>T	ENST00000588623.1	+	5	1196	c.96C>T	c.(94-96)ttC>ttT	p.F32F	ALG1_ENST00000262374.5_Silent_p.F143F|ALG1_ENST00000544428.1_Silent_p.F32F			Q9BT22	ALG1_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase	143					dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(90;0.0164)				TCTGCTGGTTCGTGGGCTGCC	0.542000													46	130					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22040797	22040797	+	Missense_Mutation	SNP	G	G	A	rs75460545	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:22040797G>A	ENST00000261200.4	-	13	1873	c.1874C>T	c.(1873-1875)tCg>tTg	p.S625L	ABCC9_ENST00000261201.4_Missense_Mutation_p.S625L|ABCC9_ENST00000345162.2_Missense_Mutation_p.S625L|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	625					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.S625L(1)		NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAAAGGAAGCGAACTTTCACC	0.398000													24	91					0	0	1	0	0
CCT7	10574	broad.mit.edu	37	2	73476202	73476202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73476202C>T	ENST00000539919.1	+	9	1106	c.735C>T	c.(733-735)gtC>gtT	p.V245V	CCT7_ENST00000538797.1_Silent_p.V161V|CCT7_ENST00000537131.1_Silent_p.V189V|CCT7_ENST00000473786.1_3'UTR|CCT7_ENST00000258091.5_Silent_p.V289V|CCT7_ENST00000398422.2_Silent_p.V85V|CCT7_ENST00000540468.1_Silent_p.V202V	NM_001166285.1	NP_001159757.1	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 (eta)	289					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding			breast(1)|cervix(1)|endometrium(1)|lung(3)|stomach(1)	7						CCAAAGTTGTCTTGTCCAAAC	0.483000													19	58					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55496418	55496418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55496418C>T	ENST00000543010.1	+	7	2177	c.2034C>T	c.(2032-2034)tcC>tcT	p.S678S	NLRP2_ENST00000339757.7_Silent_p.S656S|NLRP2_ENST00000391721.4_Silent_p.S654S|NLRP2_ENST00000427260.2_Silent_p.S655S|NLRP2_ENST00000538819.1_Silent_p.S654S|NLRP2_ENST00000263437.6_Silent_p.S675S|NLRP2_ENST00000537859.1_Silent_p.S656S|NLRP2_ENST00000448584.2_Silent_p.S678S	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	678					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CCTATAGATCCCAGGATGATC	0.433000													46	99					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72846493	72846493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72846493G>A	ENST00000293190.5	-	6	1489	c.1343C>T	c.(1342-1344)cCc>cTc	p.P448L	GRIN2C_ENST00000347612.4_Missense_Mutation_p.P448L	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	448					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CTTGGTGTAGGGGGCCACGTC	0.622000													32	119					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814304	106814304	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106814304G>A	ENST00000407775.2	+	8	2244	c.1994G>A	c.(1993-1995)gGa>gAa	p.G665E	ZFPM2_ENST00000520492.1_Missense_Mutation_p.G533E|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.G396E|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.G533E|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	665					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AAAATTAATGGAAAACCTGTT	0.433000													8	30					0	0	1	0	0
PLEKHG7	440107	broad.mit.edu	37	12	93134671	93134671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:93134671C>T	ENST00000344636.3	+	3	230	c.46C>T	c.(46-48)Ctc>Ttc	p.L16F	PLEKHG7_ENST00000549856.1_Missense_Mutation_p.L16F	NM_001004330.2	NP_001004330.1	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	16	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)	17						TCATGAATATCTCCTAGATGT	0.323000													16	50					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30898307	30898307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30898307C>T	ENST00000375712.3	+	2	894	c.727C>T	c.(727-729)Ctt>Ttt	p.L243F	KIF3B_ENST00000418717.2_5'UTR	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	243	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AAAATTGAACCTTGTAGATCT	0.512000													23	42					0	0	1	0	0
HIATL1	84641	broad.mit.edu	37	9	97209106	97209106	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:97209106C>T	ENST00000375344.3	+	7	1000	c.729_splice	c.e7-1	p.S244_splice	HIATL1_ENST00000428393.2_Splice_Site_p.S179_splice	NM_032558.2	NP_115947.2	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	244					transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	11		Acute lymphoblastic leukemia(62;0.136)				TATTCTCAGTCGTTGAAGAAA	0.353000													15	68					0	0	1	0	0
KIF5B	3799	broad.mit.edu	37	10	32320161	32320161	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:32320161A>G	ENST00000302418.4	-	14	1878	c.1421T>C	c.(1420-1422)cTg>cCg	p.L474P		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	474					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				AAGGCGATTCAGCTCAGCTTG	0.373000			T	"""RET, ALK"""	NSCLC								13	50					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248005088	248005088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248005088C>T	ENST00000355784.2	-	1	166	c.111G>A	c.(109-111)ctG>ctA	p.L37L		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L37L(2)		NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTATAATGGTCAGGCAGTAGA	0.493000													11	36					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507941	155507941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155507941G>A	ENST00000302053.3	-	5	718	c.640C>T	c.(640-642)Ccc>Tcc	p.P214S	FGA_ENST00000403106.3_Missense_Mutation_p.P214S	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	214					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCTCTAGAGGGAAGTAAGTCT	0.453000													40	85					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72346896	72346896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72346896G>A	ENST00000389916.4	+	12	1577	c.1439G>A	c.(1438-1440)cGa>cAa	p.R480Q		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	480					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GAGGAGCAGCGAAAGGAGTGC	0.647000													27	89					0	0	1	0	0
SMEK2	57223	broad.mit.edu	37	2	55792097	55792097	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:55792097G>A	ENST00000272313.5	-	12	2088	c.1761C>T	c.(1759-1761)ttC>ttT	p.F587F	SMEK2_ENST00000345102.5_Silent_p.F672F|SMEK2_ENST00000407823.3_Silent_p.F640F	NM_020463.2	NP_065196.1	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 (Dictyostelium)	672						microtubule organizing center|nucleus	protein binding			kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TCAATCCTTTGAATGTCTGAA	0.308000													13	34					0	0	1	0	0
TTC1	7265	broad.mit.edu	37	5	159492045	159492045	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:159492045C>T	ENST00000231238.5	+	8	962	c.852C>T	c.(850-852)ttC>ttT	p.F284F	TTC1_ENST00000522793.1_Silent_p.F284F|TTC1_ENST00000520274.1_3'UTR	NM_003314.1	NP_003305.1	Q99614	TTC1_HUMAN	tetratricopeptide repeat domain 1	284					protein folding		unfolded protein binding	p.F284L(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|prostate(1)|skin(1)	12	Renal(175;0.00196)	all_hematologic(541;0.00014)|Breast(839;0.0101)|all_neural(177;0.0281)|Medulloblastoma(196;0.0425)|Lung NSC(249;0.119)|all_lung(500;0.163)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	Epithelial(171;8.37e-05)|all cancers(165;0.000694)|OV - Ovarian serous cystadenocarcinoma(192;0.0402)		CCATCAATTTCGTTCAAAATC	0.423000													11	72					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92647601	92647601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:92647601C>T	ENST00000318445.6	+	4	1052	c.838C>T	c.(838-840)Ctc>Ttc	p.L280F	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.L280F|SLCO3A1_ENST00000555549.1_3'UTR	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	280					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CTTCTCTTCCCTCTTGATGTT	0.577000													12	225					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43680245	43680245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43680245C>T	ENST00000404580.1	-	3	574	c.486G>A	c.(484-486)aaG>aaA	p.K162K	PSG5_ENST00000599812.1_Silent_p.K255K|PSG5_ENST00000407356.1_Silent_p.K162K|PSG5_ENST00000342951.6_Silent_p.K162K|PSG5_ENST00000366175.3_Silent_p.K162K|PSG5_ENST00000407568.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	162	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				CTAAGACATCCTTATTCTCCC	0.493000													92	262					0	0	1	0	0
NKAIN1	79570	broad.mit.edu	37	1	31656841	31656841	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:31656841G>A	ENST00000373736.2	-	4	300	c.294C>T	c.(292-294)acC>acT	p.T98T	NKAIN1_ENST00000398657.2_Silent_p.T27T|NKAIN1_ENST00000263693.1_Silent_p.T54T	NM_024522.2	NP_078798.2	Q4KMZ8	NKAI1_HUMAN	Na+/K+ transporting ATPase interacting 1	98						integral to membrane|plasma membrane				breast(1)|cervix(1)|endometrium(1)|kidney(2)|ovary(1)|prostate(1)	7		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|Breast(348;0.141)|all_neural(195;0.146)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0184)|READ - Rectum adenocarcinoma(331;0.148)		ATGTGTTGAAGGTCATGATGA	0.612000											OREG0004725	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	23					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914285	107914285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107914285G>A	ENST00000280758.5	+	2	1685	c.1157G>A	c.(1156-1158)aGc>aAc	p.S386N	BTBD11_ENST00000420571.2_Missense_Mutation_p.S386N|BTBD11_ENST00000490090.2_Missense_Mutation_p.S386N	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	386						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CTACCAGACAGCCTGAATCTT	0.527000													30	125					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23692817	23692817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:23692817C>T	ENST00000397312.2	-	7	1092	c.818G>A	c.(817-819)gGa>gAa	p.G273E	ELAVL2_ENST00000544538.1_Missense_Mutation_p.G273E|ELAVL2_ENST00000380117.1_Missense_Mutation_p.G273E|ELAVL2_ENST00000380110.4_Missense_Mutation_p.G303E|ELAVL2_ENST00000223951.6_Missense_Mutation_p.G260E	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	273					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CCACCCTGTTCCAGGGTGCCC	0.463000													6	74					0	0	1	0	0
CUL3	8452	broad.mit.edu	37	2	225365136	225365136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:225365136G>A	ENST00000264414.4	-	11	1892	c.1554C>T	c.(1552-1554)gcC>gcT	p.A518A	CUL3_ENST00000409777.1_Silent_p.A494A|CUL3_ENST00000344951.4_Silent_p.A452A|CUL3_ENST00000409096.1_Silent_p.A494A	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	518					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ACTTTGGTGTGGCTGACTGAG	0.428000													52	121					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66479210	66479210	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:66479210C>T	ENST00000256447.4	-	3	1618	c.1461G>A	c.(1459-1461)acG>acA	p.T487T		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	487					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		GGTTGGTCTTCGTGATAGTCC	0.483000													22	53					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6061852	6061852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6061852G>A	ENST00000379959.3	-	5	809	c.636C>T	c.(634-636)tcC>tcT	p.S212S	IL2RA_ENST00000379954.1_Silent_p.S140S|IL2RA_ENST00000256876.6_Silent_p.S203S	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	212					cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TGACGAGGCAGGAAGTCTCAC	0.577000													35	86					0	0	1	0	0
LINGO4	339398	broad.mit.edu	37	1	151774528	151774528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151774528C>T	ENST00000368820.3	-	2	1590	c.653G>A	c.(652-654)aGg>aAg	p.R218K		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	218						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGCTGGCAGCCTCCCAATATC	0.657000													26	80					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124333366	124333366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124333366C>T	ENST00000409039.3	+	33	5710	c.5685C>T	c.(5683-5685)tcC>tcT	p.S1895S		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1895	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTGTGCTCTCCGTGATCTCCT	0.542000													6	21					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31740842	31740842	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31740842G>A	ENST00000266269.5	-	1	1376	c.747C>T	c.(745-747)tcC>tcT	p.S249S	PATZ1_ENST00000405309.3_Silent_p.S249S|PATZ1_ENST00000351933.4_Silent_p.S249S|PATZ1_ENST00000215919.3_Silent_p.S249S	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	249					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						TGGGGAATGGGGAAGTCAGCA	0.642000													4	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083067	9083067	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9083067G>A	ENST00000397910.4	-	1	8951	c.8748C>T	c.(8746-8748)acC>acT	p.T2916T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2917	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTCTGGAATGGTGTTCAGGG	0.483000													17	45					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149500802	149500802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149500802C>T	ENST00000261799.4	-	17	2897	c.2428G>A	c.(2428-2430)Gtg>Atg	p.V810M		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	810	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCATTGGCCACCTGGTAGCTG	0.597000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								16	49					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75442037	75442037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:75442037G>A	ENST00000549446.1	-	4	2356	c.1676C>T	c.(1675-1677)cCc>cTc	p.P559L	KCNC2_ENST00000341669.3_Missense_Mutation_p.P559L|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000548513.1_Missense_Mutation_p.P559L|KCNC2_ENST00000550433.1_Missense_Mutation_p.P559L|KCNC2_ENST00000393288.2_Missense_Mutation_p.P559L|KCNC2_ENST00000350228.2_Intron|KCNC2_ENST00000540018.1_Intron|KCNC2_ENST00000298972.1_Missense_Mutation_p.P559L	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	559					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						GCGTCTGATGGGGAGCCTTTC	0.507000													49	67					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44611651	44611651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44611651C>T	ENST00000336976.6	+	6	1592	c.1338C>T	c.(1336-1338)caC>caT	p.H446H	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	446					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				TTGACTTTCACCAGCGCGTCC	0.463000													15	101					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74480229	74480229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:74480229G>A	ENST00000394019.2	-	15	1537	c.1140C>T	c.(1138-1140)gcC>gcT	p.A380A	RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000359484.4_Silent_p.A316A|SLC4A5_ENST00000358683.4_Silent_p.A316A|SLC4A5_ENST00000357822.5_Silent_p.A380A|SLC4A5_ENST00000346834.4_Silent_p.A380A|SLC4A5_ENST00000377634.4_Silent_p.A380A|SLC4A5_ENST00000377632.1_Silent_p.A380A|SLC4A5_ENST00000423644.1_Silent_p.A380A|SLC4A5_ENST00000483195.1_5'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	380						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CCCGATTGCGGGCTTTGTAGG	0.512000													19	43					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3329121	3329121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3329121C>T	ENST00000378398.3	+	10	2445	c.2363C>T	c.(2362-2364)cCc>cTc	p.P788L	PRDM16_ENST00000378391.2_Missense_Mutation_p.P787L|PRDM16_ENST00000442529.2_Missense_Mutation_p.P787L|PRDM16_ENST00000441472.2_Missense_Mutation_p.P787L|PRDM16_ENST00000514189.1_Missense_Mutation_p.P788L|PRDM16_ENST00000511072.1_Missense_Mutation_p.P788L|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Missense_Mutation_p.P787L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	787	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCCATCCTGCCCATGCCCAAG	0.711000			T	EVI1	"""MDS, AML"""								6	62					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91805699	91805699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91805699G>A	ENST00000389857.6	-	8	818	c.732C>T	c.(730-732)ctC>ctT	p.L244L		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	244					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTTCGCTAGAGAGGCTGCTGG	0.657000													7	27					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238441	3238441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3238441C>T	ENST00000217939.6	-	5	5439	c.5285G>A	c.(5284-5286)aGa>aAa	p.R1762K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1762						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AATAACTTTTCTCTCTCTCAT	0.512000													19	11					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123811000	123811000	+	Missense_Mutation	SNP	G	G	A	rs142766960		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123811000G>A	ENST00000307033.2	+	1	751	c.677G>A	c.(676-678)cGa>cAa	p.R226Q		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GTCATGCTCCGAAGCCACTCA	0.507000													68	253					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167823624	167823624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167823624C>T	ENST00000367848.1	-	18	2496	c.1999G>A	c.(1999-2001)Gaa>Aaa	p.E667K	ADCY10_ENST00000367851.4_Missense_Mutation_p.E759K|ADCY10_ENST00000545172.1_Missense_Mutation_p.E606K			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	759					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTTGTCTTTTCCTCAGACTCC	0.438000													39	121					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169787178	169787178	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169787178C>G	ENST00000263817.6	-	25	3532	c.3408G>C	c.(3406-3408)aaG>aaC	p.K1136N		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1136	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GGCTTACCACCTTCCCTTGAT	0.463000													7	25					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99448892	99448892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99448892C>T	ENST00000397899.2	-	5	790	c.459G>A	c.(457-459)atG>atA	p.M153I	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like																		CCTCAGAGCTCATGCCGGCAT	0.572000													30	54					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878874	24878874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24878874C>T	ENST00000382554.3	+	4	2192	c.1874C>T	c.(1873-1875)cCc>cTc	p.P625L		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	625					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCAAAAACTCCCCAGGCTCAG	0.502000													5	12					0	0	1	0	0
FGF19	9965	broad.mit.edu	37	11	69514115	69514115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:69514115G>A	ENST00000294312.3	-	3	1331	c.566C>T	c.(565-567)tCt>tTt	p.S189F		NM_005117.2	NP_005108.1	O95750	FGF19_HUMAN	fibroblast growth factor 19	189					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			large_intestine(2)|lung(2)|skin(2)	6	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			CAGGGGCGAAGAGAACATGTC	0.577000													34	95					0	0	1	0	0
OR4F6	390648	broad.mit.edu	37	15	102346082	102346082	+	Missense_Mutation	SNP	C	C	T	rs141580524	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:102346082C>T	ENST00000328882.4	+	1	181	c.160C>T	c.(160-162)Cgt>Tgt	p.R54C		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTCTGACCCTCGTTTACAGTC	0.468000													259	325					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15579516	15579516	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15579516C>T	ENST00000340880.4	-	5	2169	c.1689G>A	c.(1687-1689)agG>agA	p.R563R	PGLYRP2_ENST00000292609.4_3'UTR	NM_052890.3	NP_443122.3	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	563					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GGGGTGGCTCCCTCCTGGATC	0.517000													19	65					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055504	75055504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75055504C>T	ENST00000326665.5	-	12	2205	c.1987G>A	c.(1987-1989)Gaa>Aaa	p.E663K	C1orf173_ENST00000420661.2_Missense_Mutation_p.E466K|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	663	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCAAAGCTTTCGTCTATTGGC	0.408000													26	108					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7750676	7750676	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7750676C>T	ENST00000254846.5	+	10	1552	c.1163C>T	c.(1162-1164)tCc>tTc	p.S388F	KDM6B_ENST00000448097.2_Missense_Mutation_p.S388F	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	388	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						TACGCCCCTTCCCGGCCCCCT	0.657000													75	88					0	0	1	0	0
PDE10A	10846	broad.mit.edu	37	6	165749672	165749672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:165749672G>A	ENST00000366882.1	-	22	2331	c.2177C>T	c.(2176-2178)cCc>cTc	p.P726L	PDE10A_ENST00000539869.2_Missense_Mutation_p.P736L|PDE10A_ENST00000354448.4_Missense_Mutation_p.P726L			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	726					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TGTATAGCAGGGAATGGCCAC	0.443000													9	17					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63044633	63044633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:63044633G>A	ENST00000251157.5	-	17	1909	c.1876C>T	c.(1876-1878)Cct>Tct	p.P626S	DOCK7_ENST00000340370.5_Missense_Mutation_p.P626S	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	626	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TGAAAATCAGGAGACCTTCAT	0.254000													30	66					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	133119350	133119350	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:133119350G>A	ENST00000370818.3	-	1	572	c.127C>T	c.(127-129)Cag>Tag	p.Q43*	GPC3_ENST00000543339.1_Nonsense_Mutation_p.Q43*|GPC3_ENST00000394299.2_Nonsense_Mutation_p.Q43*	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	43						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					TGCAGTCTCTGGAAGAAGGAG	0.692000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				7	6					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121767694	121767694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121767694G>A	ENST00000261367.7	+	8	2782	c.1354G>A	c.(1354-1356)Gtg>Atg	p.V452M	SNCAIP_ENST00000261368.8_Missense_Mutation_p.V405M|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000542191.1_5'UTR|SNCAIP_ENST00000379538.3_Missense_Mutation_p.V39M|SNCAIP_ENST00000379536.2_Missense_Mutation_p.V345M|SNCAIP_ENST00000503116.2_Missense_Mutation_p.V452M|SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000379533.2_Missense_Mutation_p.V452M			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	405					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACGCTGGATGGTGAGCGAAAC	0.403000													8	41					0	0	1	0	0
KLHL12	59349	broad.mit.edu	37	1	202861744	202861744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202861744G>A	ENST00000367261.3	-	12	1842	c.1624C>T	c.(1624-1626)Cct>Tct	p.P542S	KLHL12_ENST00000367259.1_3'UTR|KLHL12_ENST00000435533.3_Missense_Mutation_p.P580S	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	542	Interaction with DVL3.				Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			TCGATGATAGGGTCATAACAT	0.493000													13	59					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179516823	179516823	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179516823C>T	ENST00000589042.1	-	204	39519	c.39295_splice	c.e204+1	p.V13099_splice	TTN_ENST00000342992.6_Splice_Site_p.V10665_splice|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Splice_Site_p.V11592_splice|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11452			Q -> R (in a lung small cell carcinoma sample; somatic mutation).				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATTATTACCTTCAGGGGGA	0.353000													34	87					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44589351	44589351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44589351G>A	ENST00000322927.2	-	12	1786	c.1686C>T	c.(1684-1686)ttC>ttT	p.F562F	ZNF335_ENST00000426788.1_Silent_p.F407F	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				CAGGGCAGGGGAAAGAGCTCA	0.557000													30	92					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831429	61831429	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61831429G>A	ENST00000280772.1	-	37	9401	c.9210C>T	c.(9208-9210)ccC>ccT	p.P3070P	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3070					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATCCATCAATGGGACTGTGGT	0.468000													40	139					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603157	111603157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111603157G>A	ENST00000431670.2	+	2	644	c.233G>A	c.(232-234)aGt>aAt	p.S78N	PHLDB2_ENST00000412622.1_Missense_Mutation_p.S78N|PHLDB2_ENST00000477695.1_Missense_Mutation_p.S78N|PHLDB2_ENST00000481953.1_Missense_Mutation_p.S78N|PHLDB2_ENST00000393925.3_Missense_Mutation_p.S78N|PHLDB2_ENST00000478922.1_Missense_Mutation_p.S78N|PHLDB2_ENST00000393923.3_Missense_Mutation_p.S105N	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	78						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TTGGGAACCAGTGTCAGAAGC	0.453000													24	258					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49585897	49585897	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49585897G>A	ENST00000371175.4	-	3	402	c.376C>T	c.(376-378)Ctg>Ttg	p.L126L	RHAG_ENST00000229810.7_Silent_p.L126L	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	126					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					AAAGATATCAGAACTGTGGCT	0.403000													16	33					0	0	1	0	0
ICAM4	3386	broad.mit.edu	37	19	10398444	10398444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10398444C>T	ENST00000393717.2	+	2	636	c.627C>T	c.(625-627)atC>atT	p.I209I	ICAM4_ENST00000380770.3_Silent_p.I209I|CTD-2369P2.8_ENST00000589379.1_RNA|ICAM4_ENST00000340992.4_Silent_p.L184L	NM_022377.3	NP_071772.1	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	209	Ig-like C2-type 2.				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			breast(1)|large_intestine(3)|lung(2)|pancreas(1)	7			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			AGCCCGTGATCTGCCACGCGC	0.627000													9	94					0	0	1	0	0
NDUFAF1	51103	broad.mit.edu	37	15	41679779	41679779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41679779C>T	ENST00000260361.4	-	5	1228	c.847G>A	c.(847-849)Gga>Aga	p.G283R		NM_016013.3	NP_057097.2	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1	283					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	12		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		AAGGTGAATCCTATAGAAGAG	0.358000													17	67					0	0	1	0	0
CD63	967	broad.mit.edu	37	12	56121019	56121019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56121019G>A	ENST00000549117.1	-	3	607	c.171C>T	c.(169-171)atC>atT	p.I57I	CD63_ENST00000552692.1_Silent_p.I57I|CD63_ENST00000552754.1_Silent_p.I34I|CD63_ENST00000550776.1_5'UTR|CD63_ENST00000257857.4_Silent_p.I57I|CD63_ENST00000546939.1_5'UTR|CD63_ENST00000420846.3_Silent_p.I57I	NM_001257389.1	NP_001244318.1	P08962	CD63_HUMAN	CD63 molecule	57					platelet activation|platelet degranulation	integral to plasma membrane|late endosome membrane|lysosomal membrane|platelet dense granule membrane				kidney(1)|large_intestine(3)|lung(2)|ovary(1)	7						CCACTGCGATGATGACCACTG	0.592000													34	132					0	0	1	0	0
TTC29	83894	broad.mit.edu	37	4	147795922	147795922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:147795922C>T	ENST00000513335.1	-	8	1022	c.823G>A	c.(823-825)Gaa>Aaa	p.E275K	TTC29_ENST00000325106.4_Missense_Mutation_p.E249K|TTC29_ENST00000398886.4_Missense_Mutation_p.E275K			Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	249							binding			breast(2)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					TGTTTGTATTCTTTATTTTCT	0.403000													6	21					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52509050	52509050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52509050G>A	ENST00000242839.4	-	21	4396	c.4240C>T	c.(4240-4242)Ccc>Tcc	p.P1414S	ATP7B_ENST00000400366.3_Missense_Mutation_p.P1303S|ATP7B_ENST00000417240.2_Missense_Mutation_p.P625S|ATP7B_ENST00000400370.3_Missense_Mutation_p.P984S|ATP7B_ENST00000418097.2_Missense_Mutation_p.P1349S|ATP7B_ENST00000448424.2_Missense_Mutation_p.P1336S|ATP7B_ENST00000344297.5_Missense_Mutation_p.P1207S	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1414					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GTGGCCCTGGGGGAGTCCCGC	0.632000									Wilson disease				22	52					0	0	1	0	0
RETN	56729	broad.mit.edu	37	19	7734761	7734761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7734761G>A	ENST00000221515.2	+	3	261	c.173G>A	c.(172-174)gGg>gAg	p.G58E	RETN_ENST00000381324.2_Intron	NM_001193374.1|NM_020415.3	NP_001180303.1|NP_065148.1	Q9HD89	RETN_HUMAN	resistin	58							hormone activity			ovary(1)	1						ACCTCCAGGGGGGACCTGGCT	0.617000													15	33					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7287996	7287996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7287996G>A	ENST00000537408.1	+	3	1031	c.493G>A	c.(493-495)Gct>Act	p.A165T	CLSTN3_ENST00000266546.6_Missense_Mutation_p.A153T			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	153	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GTATCGTGCGGCTGTGACAGA	0.562000													26	56					0	0	1	0	0
SPATA9	83890	broad.mit.edu	37	5	95018270	95018270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:95018270C>T	ENST00000274432.8	-	2	253	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	SPATA9_ENST00000395899.3_Missense_Mutation_p.E38K|RFESD_ENST00000508206.1_Intron|SPATA9_ENST00000477047.2_5'UTR	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	38					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		GTGGGAAATTCATCTTTAAAC	0.313000													23	66					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231201	7231201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:7231201G>A	ENST00000383467.2	+	1	79	c.65G>A	c.(64-66)gGg>gAg	p.G22E		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	22										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CTGTTCACGGGGAGGAGACAG	0.617000													10	79					0	0	1	0	0
AMTN	401138	broad.mit.edu	37	4	71388496	71388496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71388496C>T	ENST00000339336.4	+	3	209	c.79C>T	c.(79-81)Cct>Tct	p.P27S	AMTN_ENST00000504451.1_Missense_Mutation_p.P26S	NM_212557.2	NP_997722.1	Q6UX39	AMTN_HUMAN	amelotin	27					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				NS(3)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)|skin(1)	19			Lung(101;0.235)			TTTGGGACTCCCTCCCACAAA	0.423000													70	237					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36166573	36166573	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36166573G>A	ENST00000303965.4	-	11	2625	c.2136C>T	c.(2134-2136)tcC>tcT	p.S712S		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	712	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGAGATTGATGGATGCCCAGT	0.428000													11	95					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88284477	88284477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:88284477G>A	ENST00000357081.3	-	8	729	c.585C>T	c.(583-585)tcC>tcT	p.S195S	AGTPBP1_ENST00000376081.4_Silent_p.S195S|AGTPBP1_ENST00000432218.1_Silent_p.S33S|AGTPBP1_ENST00000491784.1_5'UTR|AGTPBP1_ENST00000337006.4_Silent_p.S137S|AGTPBP1_ENST00000376080.1_Silent_p.S137S|AGTPBP1_ENST00000376083.3_Silent_p.S195S|AGTPBP1_ENST00000376109.3_Silent_p.S247S			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	195					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						TTTTCCCTAAGGATACTGAAT	0.328000													9	85					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52495482	52495482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:52495482G>A	ENST00000216286.5	-	11	2487	c.2488C>T	c.(2488-2490)Cgg>Tgg	p.R830W	NID2_ENST00000541773.1_Missense_Mutation_p.R777W	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	830	EGF-like 3; calcium-binding (Potential).		R -> Q (in dbSNP:rs7144523).			basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TAACCACTCCGGCACTCACAC	0.443000													23	38					0	0	1	0	0
GPR15	2838	broad.mit.edu	37	3	98251249	98251249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98251249C>T	ENST00000284311.3	+	1	507	c.372C>T	c.(370-372)ctC>ctT	p.L124L		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	124						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		TCCTCCTGCTCACTTGCATGA	0.512000													9	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061525	9061525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9061525G>A	ENST00000397910.4	-	3	26124	c.25921C>T	c.(25921-25923)Ccc>Tcc	p.P8641S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8643	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTGAGGAGGGATGAATTTTC	0.428000													24	62					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28660122	28660122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28660122C>T	ENST00000280904.6	-	10	1903	c.1460G>A	c.(1459-1461)gGa>gAa	p.G487E	DSC2_ENST00000251081.6_Missense_Mutation_p.G487E	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	487	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GCTTGTTGTTCCCACTTCTGC	0.383000													46	97					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50666517	50666517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:50666517C>T	ENST00000371821.1	+	7	1140	c.825C>T	c.(823-825)ccC>ccT	p.P275P	ELAVL4_ENST00000357083.4_Intron|ELAVL4_ENST00000371824.1_Intron|ELAVL4_ENST00000371823.4_Silent_p.P270P|ELAVL4_ENST00000448907.2_Intron|ELAVL4_ENST00000371819.1_Intron|ELAVL4_ENST00000371827.1_Intron			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	270					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						CTGCTTGTCCCCCCAGGTTCT	0.522000													45	196					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41792152	41792152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41792152G>A	ENST00000396930.3	-	18	4129	c.3586C>T	c.(3586-3588)Cct>Tct	p.P1196S	KAT6A_ENST00000265713.2_Missense_Mutation_p.P1196S|KAT6A_ENST00000406337.1_Missense_Mutation_p.P1196S	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1196					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										CCAGCTTTAGGAATGGAAACG	0.483000													25	140					0	0	1	0	0
FAM124B	79843	broad.mit.edu	37	2	225265794	225265794	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:225265794C>T	ENST00000389874.3	-	1	917	c.692G>A	c.(691-693)tGg>tAg	p.W231*	FAM124B_ENST00000409685.3_Nonsense_Mutation_p.W231*|FAM124B_ENST00000243806.2_Nonsense_Mutation_p.W231*	NM_024785.2	NP_079061.2	Q9H5Z6	F124B_HUMAN	family with sequence similarity 124B	231							protein binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	16		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		CTGAGTCTGCCACCTGGTGCT	0.488000													23	75					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131476552	131476552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131476552C>T	ENST00000291906.4	+	11	1782	c.1389C>T	c.(1387-1389)ccC>ccT	p.P463P		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	463	Pro-rich.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						ACCTGCTGCCCCCCTGCAGCT	0.647000													48	124					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61939428	61939428	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61939428G>A	ENST00000422202.1	+	6	850	c.782G>A	c.(781-783)gGg>gAg	p.G261E	COL20A1_ENST00000326996.6_Missense_Mutation_p.G254E|COL20A1_ENST00000435874.1_Missense_Mutation_p.G261E|COL20A1_ENST00000358894.6_Missense_Mutation_p.G254E			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	254	VWFA.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					TACAAGGGGGGGAACACGTTC	0.627000													12	28					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25936266	25936266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:25936266C>T	ENST00000398988.3	+	18	2236	c.1791C>T	c.(1789-1791)ctC>ctT	p.L597L	KSR1_ENST00000268763.6_Silent_p.L597L|KSR1_ENST00000509603.2_Silent_p.L712L|KSR1_ENST00000319524.6_Silent_p.L734L	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	732					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		ACAAAGATCTCAAATCTAAGA	0.532000													25	20					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44803639	44803639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44803639C>T	ENST00000372262.3	-	11	2393	c.1993G>A	c.(1993-1995)Gac>Aac	p.D665N	CDH22_ENST00000537909.1_Missense_Mutation_p.D665N	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	665					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				ATGACGTTGTCCCGCATGTCT	0.627000													15	46					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288793	107288793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107288793C>T	ENST00000277216.3	-	1	697	c.698G>A	c.(697-699)gGa>gAa	p.G233E		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						CTTGTGTCTTCCTGTGGCCGA	0.428000													55	117					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327717	52327717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52327717C>T	ENST00000339223.4	+	2	895	c.716C>T	c.(715-717)cCc>cTc	p.P239L	FPR3_ENST00000595991.1_Missense_Mutation_p.P239L	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	239					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TCCAGCCGTCCCTTACGTGTC	0.453000													19	41					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37709492	37709492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37709492C>T	ENST00000248901.6	+	13	1312	c.1125C>T	c.(1123-1125)acC>acT	p.T375T		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	375	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CCAGCATCACCCGTGTCCCCT	0.577000													24	76					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151376575	151376575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151376575C>T	ENST00000370314.4	-	7	914	c.676G>A	c.(676-678)Gga>Aga	p.G226R	GABRA3_ENST00000535043.1_Missense_Mutation_p.G226R|GABRA3_ENST00000370311.1_Missense_Mutation_p.G226R	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	226					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTGTTCTTTCCGAGAGTCCAA	0.448000													55	35					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158900900	158900900	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:158900900C>T	ENST00000367097.3	+	7	2501	c.1144C>T	c.(1144-1146)Cag>Tag	p.Q382*	TULP4_ENST00000367094.2_Nonsense_Mutation_p.Q382*	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	382	SOCS box.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GCTGCTGTGCCAGCAGGCCAT	0.647000													22	31					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160458917	160458917	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160458917C>T	ENST00000368059.3	-	6	906	c.837G>A	c.(835-837)acG>acA	p.T279T	SLAMF6_ENST00000368055.1_Silent_p.T169T|SLAMF6_ENST00000368057.3_Silent_p.T280T	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	280						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			CAGTGTTGTTCGTTGGAGACA	0.443000													43	101					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31294509	31294509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:31294509G>A	ENST00000542188.1	-	27	4758	c.4445C>T	c.(4444-4446)tCc>tTc	p.S1482F	TRPM1_ENST00000397795.2_Missense_Mutation_p.S1443F|RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000256552.6_Missense_Mutation_p.S1465F	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1443					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TCTTCCCCGGGAATAGACGAA	0.453000													45	88					0	0	1	0	0
TMEM8C	389827	broad.mit.edu	37	9	136380695	136380695	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136380695G>A	ENST00000339996.3	-	4	535	c.434C>T	c.(433-435)cCa>cTa	p.P145L	TMEM8C_ENST00000413714.1_5'UTR	NM_001080483.2	NP_001073952.1	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	145						integral to membrane				NS(1)|autonomic_ganglia(1)|large_intestine(2)|lung(4)	8						GCTCTTGTCTGGGTACAGGCC	0.597000													30	48					0	0	1	0	0
SLC39A8	64116	broad.mit.edu	37	4	103188658	103188658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:103188658G>A	ENST00000424970.2	-	8	1537	c.1222C>T	c.(1222-1224)Ctg>Ttg	p.L408L	SLC39A8_ENST00000356736.4_Silent_p.L408L|SLC39A8_ENST00000394833.2_Silent_p.L408L	NM_001135147.1	NP_001128619.1	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter), member 8	408						integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity			large_intestine(1)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		ATATCTGCCAGAGAAATATAG	0.358000													12	52					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181745299	181745299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181745299C>T	ENST00000526775.1	+	37	5310	c.5145C>T	c.(5143-5145)tcC>tcT	p.S1715S	CACNA1E_ENST00000367570.1_Silent_p.S1734S|CACNA1E_ENST00000367567.4_Silent_p.S1341S|CACNA1E_ENST00000360108.3_Silent_p.S1715S|CACNA1E_ENST00000357570.5_Silent_p.S1685S|CACNA1E_ENST00000358338.5_Silent_p.S1666S|CACNA1E_ENST00000367573.2_Silent_p.S1734S	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1734					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GGGACTCCTCCATCCTGGGGC	0.607000													71	157					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31595112	31595112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31595112C>T	ENST00000379416.3	-	17	1886	c.1838G>A	c.(1837-1839)cGg>cAg	p.R613Q		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	613					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GGCGTGGGCCCGGGTGCTGGT	0.622000													51	149					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531646	50531646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50531646G>A	ENST00000374144.3	+	3	1344	c.1056G>A	c.(1054-1056)agG>agA	p.R352R	C10orf71_ENST00000323868.4_Silent_p.R352R			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	352										endometrium(1)	1						GGGGGTGCAGGGATCCAGGAG	0.582000													16	32					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564418	176564418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176564418C>T	ENST00000367662.3	+	3	2842	c.1678C>T	c.(1678-1680)Cgc>Tgc	p.R560C	PAPPA2_ENST00000367661.3_Missense_Mutation_p.R560C	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	560	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGCCTTCAGCCGCTACAACAT	0.557000													14	63					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	53883852	53883852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:53883852G>A	ENST00000514921.1	+	1	139	c.26G>A	c.(25-27)aGa>aAa	p.R9K	MLIP_ENST00000370877.2_Missense_Mutation_p.R9K|MLIP_ENST00000509997.1_Missense_Mutation_p.R9K|MLIP_ENST00000274897.5_Missense_Mutation_p.R9K			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	9	Interaction with LMNA.					nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						CGTGAAAAAAGAAGCTTATTA	0.363000													15	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438476	179438476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179438476C>T	ENST00000589042.1	-	326	72607	c.72383G>A	c.(72382-72384)gGa>gAa	p.G24128E	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G21560E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G22487E|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G15255E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G15188E|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G15063E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22487	Fibronectin type-III 75.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCAAAGGTCCTTCAGGTGG	0.448000													29	94					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83456104	83456104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83456104C>T	ENST00000334574.8	-	2	220	c.39G>A	c.(37-39)agG>agA	p.R13R	FSD2_ENST00000541889.1_Silent_p.R13R			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	13										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						TGGGAGTAGACCTGTCCAGCC	0.468000													65	64					0	0	1	0	0
GALNT2	2590	broad.mit.edu	37	1	230338999	230338999	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230338999C>T	ENST00000366672.4	+	3	409	c.337C>T	c.(337-339)Cga>Tga	p.R113*	GALNT2_ENST00000541865.1_Nonsense_Mutation_p.R23*|GALNT2_ENST00000543760.1_Nonsense_Mutation_p.R75*	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	113					immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				TGATAAGCTTCGAATGGACAG	0.537000													42	97					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160811241	160811241	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160811241C>T	ENST00000368034.4	-	3	591	c.414G>A	c.(412-414)ggG>ggA	p.G138G	CD244_ENST00000368033.3_Silent_p.G143G|CD244_ENST00000368032.2_Silent_p.G138G|CD244_ENST00000322302.7_Intron	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	143	Ig-like 2.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCAGGATCTTCCCCTGCCCCT	0.507000													34	82					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94580218	94580218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:94580218C>T	ENST00000258526.4	+	4	1657	c.1408C>T	c.(1408-1410)Cct>Tct	p.P470S		NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	470					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AGCCACAGACCCTCACTGCGG	0.443000													10	42					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52945956	52945956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52945956C>T	ENST00000295213.4	+	9	1600	c.1226C>T	c.(1225-1227)cCt>cTt	p.P409L	SPATA18_ENST00000419395.2_Missense_Mutation_p.P377L	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	409					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCATTCCCTCCTGTCGTTGAC	0.438000													90	218					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527037	23527037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:23527037G>A	ENST00000296682.3	+	11	2022	c.1840G>A	c.(1840-1842)Ggg>Agg	p.G614R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	614					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.G614W(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CAGGGAGTGTGGGCGGGGCTT	0.622000										HNSCC(3;0.000094)			12	73					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86389422	86389422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:86389422C>T	ENST00000285379.5	+	6	811	c.581C>T	c.(580-582)cCa>cTa	p.P194L		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	194					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TGGACCTACCCAGGCTCACTG	0.512000													32	240					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198713186	198713186	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:198713186C>T	ENST00000367376.2	+	26	2866	c.2695C>T	c.(2695-2697)Cag>Tag	p.Q899*	PTPRC_ENST00000352140.3_Nonsense_Mutation_p.Q851*|PTPRC_ENST00000348564.6_Nonsense_Mutation_p.Q740*|PTPRC_ENST00000442510.2_Nonsense_Mutation_p.Q901*|PTPRC_ENST00000594404.1_Nonsense_Mutation_p.Q738*	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	899	Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						ATTGTAGGCCCAGTACATCTT	0.328000													10	41					0	0	1	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48519169	48519169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48519169C>T	ENST00000339841.2	+	4	406	c.228C>T	c.(226-228)ttC>ttT	p.F76F	ELSPBP1_ENST00000597519.1_Intron	NM_022142.4	NP_071425.3	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1	76	Fibronectin type-II 2.				single fertilization	extracellular region				NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(6)	10		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		GCTGTATCTTCCCTTTCATCT	0.458000													19	49					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86702171	86702171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86702171G>A	ENST00000441037.2	+	4	359	c.264G>A	c.(262-264)atG>atA	p.M88I	AGBL1_ENST00000421325.2_Missense_Mutation_p.M88I	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	88					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TAGTCTCCATGGGAGCCATGC	0.443000													31	111					0	0	1	0	0
RIT2	6014	broad.mit.edu	37	18	40695469	40695469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:40695469C>T	ENST00000589109.1	-	1	187	c.16G>A	c.(16-18)Gaa>Aaa	p.E6K	RIT2_ENST00000326695.5_Missense_Mutation_p.E6K|RIT2_ENST00000282028.4_Missense_Mutation_p.E6K|RIT2_ENST00000590910.1_Missense_Mutation_p.E6K	NM_001272077.1	NP_001259006.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	6					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CAGCTGGCTTCATTTTCTACC	0.517000													23	88					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125599088	125599088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125599088C>T	ENST00000316519.6	+	9	1187	c.981C>T	c.(979-981)ctC>ctT	p.L327L	AACS_ENST00000261686.6_Silent_p.L327L|AACS_ENST00000316543.10_5'UTR	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	327					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		GTGACATCCTCCTGTGCTACA	0.602000													8	31					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11343898	11343898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11343898G>A	ENST00000294618.7	-	22	2710	c.2699C>T	c.(2698-2700)tCc>tTc	p.S900F	DOCK6_ENST00000319867.7_Missense_Mutation_p.S204F	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	900					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CAGGATGCGGGAAACCTCGTC	0.622000													10	21					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38952011	38952011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38952011G>A	ENST00000359357.3	+	85	12584	c.12330G>A	c.(12328-12330)atG>atA	p.M4110I	DNAH8_ENST00000441566.1_Missense_Mutation_p.M4074I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTCGGTACATGATCGGAGAAG	0.343000													16	85					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291424	33291424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:33291424G>A	ENST00000280979.4	+	13	4575	c.4405G>A	c.(4405-4407)Gat>Aat	p.D1469N	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1469					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TACATTTTATGATTACTCATA	0.373000													19	30					0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138418941	138418941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138418941G>A	ENST00000310018.2	-	16	1913	c.1631C>T	c.(1630-1632)tCg>tTg	p.S544L	ATP6V0A4_ENST00000353492.4_Missense_Mutation_p.S544L|ATP6V0A4_ENST00000393054.1_Missense_Mutation_p.S544L	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	544					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CAGGATCACCGACATCTTCAT	0.428000													31	68					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113803741	113803741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113803741G>A	ENST00000260191.2	+	6	879	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K	HTR3B_ENST00000537778.1_Missense_Mutation_p.E197K	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	208					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CAGTGAGTGGGAACTTCTATC	0.473000													7	57					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382199	152382199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152382199G>A	ENST00000271835.3	-	3	1421	c.1359C>T	c.(1357-1359)ctC>ctT	p.L453L	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	453					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGTCCAGCCTGAGGATCACTG	0.572000													30	87					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77948989	77948989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77948989C>T	ENST00000393684.3	-	5	776	c.385G>A	c.(385-387)Gac>Aac	p.D129N	ISM2_ENST00000429906.1_Missense_Mutation_p.D136N|ISM2_ENST00000342219.4_Missense_Mutation_p.D217N|ISM2_ENST00000493585.1_Intron|ISM2_ENST00000412904.1_Missense_Mutation_p.D136N			Q6H9L7	ISM2_HUMAN	isthmin 2	217						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						GCCTGGGGGTCCTCCACCACC	0.627000													47	101					0	0	1	0	0
GBP3	2635	broad.mit.edu	37	1	89481012	89481012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:89481012G>A	ENST00000370481.4	-	3	496	c.276C>T	c.(274-276)acC>acT	p.T92T	GBP3_ENST00000475853.2_5'UTR	NM_018284.2	NP_060754.2	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	92						integral to membrane	GTP binding|GTPase activity			breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		GCAGGACTAAGGTGTGTTCTG	0.458000													48	131					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54343015	54343015	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:54343015T>C	ENST00000306888.2	-	8	1760	c.1509A>G	c.(1507-1509)gaA>gaG	p.E503E	LNX1_ENST00000263925.7_Silent_p.E599E|FIP1L1_ENST00000507166.1_Intron	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	599						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGCTGCAGTCTTCCTGGGGCT	0.537000													12	130					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41796986	41796986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41796986G>A	ENST00000263800.6	-	17	2201	c.2105C>T	c.(2104-2106)tCc>tTc	p.S702F	LTK_ENST00000355166.5_Missense_Mutation_p.S641F|LTK_ENST00000453182.2_Missense_Mutation_p.S572F|LTK_ENST00000561619.1_Missense_Mutation_p.S400F	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	702	Protein kinase.				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		ATCTGTCTTGGATGTGAAGAT	0.607000										TSP Lung(18;0.14)			20	56					0	0	1	0	0
NRG2	9542	broad.mit.edu	37	5	139232060	139232060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139232060G>A	ENST00000541337.1	-	6	1532	c.1303C>T	c.(1303-1305)Cct>Tct	p.P435S	NRG2_ENST00000289409.4_Missense_Mutation_p.P495S|NRG2_ENST00000358522.3_Missense_Mutation_p.P503S|NRG2_ENST00000545385.1_Missense_Mutation_p.P503S|NRG2_ENST00000361474.1_Missense_Mutation_p.P501S|NRG2_ENST00000340391.3_Missense_Mutation_p.P298S|NRG2_ENST00000394770.1_3'UTR|CTB-35F21.4_ENST00000504413.1_RNA|NRG2_ENST00000289422.7_Missense_Mutation_p.P509S	NM_001184935.1	NP_001171864.1	O14511	NRG2_HUMAN	neuregulin 2	501					embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	25			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGAGAAGGAGAACAGGAG	0.532000													11	87					0	0	1	0	0
EAPP	55837	broad.mit.edu	37	14	35005444	35005444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:35005444G>A	ENST00000250454.3	-	2	193	c.112C>T	c.(112-114)Cct>Tct	p.P38S		NM_018453.3	NP_060923.2	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	38					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	12	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		TTTTGGTCAGGAGTTCCATGT	0.318000													20	42					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103260388	103260388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:103260388G>A	ENST00000553106.1	-	5	967	c.495C>T	c.(493-495)gcC>gcT	p.A165A	PAH_ENST00000307000.2_Silent_p.A160A|PAH_ENST00000551988.1_Intron	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	165					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	GGTAGTTGTAGGCAATGTCAG	0.488000													11	83					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149481113	149481113	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149481113G>A	ENST00000378016.2	+	0	2595							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTCCTCTGGGGCTGCTGTGGG	0.642000													6	16					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39602432	39602432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39602432G>A	ENST00000352251.3	-	5	1134	c.301C>T	c.(301-303)Cgt>Tgt	p.R101C	PROSER1_ENST00000350125.3_Missense_Mutation_p.R79C	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	101																	TCAATAGGACGAGAATTCTGT	0.338000													12	24					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119064785	119064785	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119064785G>A	ENST00000296499.5	+	6	1888	c.1485G>A	c.(1483-1485)gaG>gaA	p.E495E	NDST3_ENST00000433996.2_Silent_p.E414E	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	495	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						GTCCTAAAGAGCTGGATAAGA	0.403000													28	52					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206166306	206166306	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206166306G>A	ENST00000406610.2	+	18	2718	c.2511G>A	c.(2509-2511)acG>acA	p.T837T	PARD3B_ENST00000351153.1_Silent_p.T768T|PARD3B_ENST00000462231.1_Silent_p.T837T|PARD3B_ENST00000349953.3_Silent_p.T837T|PARD3B_ENST00000358768.2_Silent_p.T775T	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	837	Lys-rich.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TCAAAAAAACgaaagagaagg	0.433000													26	42					0	0	1	0	0
SENP8	123228	broad.mit.edu	37	15	72432138	72432138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72432138C>T	ENST00000544411.1	+	3	661	c.174C>T	c.(172-174)gtC>gtT	p.V58V	SENP8_ENST00000542035.2_Silent_p.V58V|SENP8_ENST00000340912.4_Silent_p.V58V|SENP8_ENST00000544171.1_Silent_p.V58V	NM_001172109.1|NM_001172110.1	NP_001165580.1|NP_001165581.1	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	58	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			breast(1)|kidney(2)|lung(1)|ovary(1)|skin(1)	6						GCCCTGAAGTCACCCAGTTCA	0.463000													96	129					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043700	20043700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20043700G>A	ENST00000570682.1	-	2	719	c.419C>T	c.(418-420)tCa>tTa	p.S140L		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	140						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						GGCTGGGTATGAGACCGTGTG	0.507000													32	83					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44974301	44974301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:44974301G>A	ENST00000340446.4	-	1	2181	c.1890C>T	c.(1888-1890)gcC>gcT	p.A630A		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	630	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		CTTCAGCGGGGGCCTCCTCAG	0.642000													5	27					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587196	36587196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36587196C>T	ENST00000332987.1	-	7	1393	c.971G>A	c.(970-972)aGg>aAg	p.R324K	APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000352371.1_Missense_Mutation_p.R327K			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	328					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						AGCCCACTGCCTCAGCGACTC	0.537000													6	19					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158152041	158152041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158152041C>T	ENST00000368171.3	+	4	1047	c.548C>T	c.(547-549)aCc>aTc	p.T183I		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	183					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CTTAATGGCACCTGCCCCCAA	0.552000													52	211					0	0	1	0	0
GNRHR	2798	broad.mit.edu	37	4	68610308	68610308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68610308C>T	ENST00000420975.2	-	2	591	c.592G>A	c.(592-594)Ggt>Agt	p.G198S	GNRHR_ENST00000226413.4_Silent_p.R240R|RP11-453E17.1_ENST00000500538.2_RNA|RP11-453E17.1_ENST00000502758.1_RNA	NM_001012763.1	NP_001012781.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	0					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	GATGAAGGACCCGTGTCAGGG	0.413000													14	65					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74627479	74627479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74627479G>A	ENST00000268082.4	+	9	1090	c.1070G>A	c.(1069-1071)gGa>gAa	p.G357E	CCDC33_ENST00000398814.3_Intron|CCDC33_ENST00000321288.5_Intron|CCDC33_ENST00000558821.1_Missense_Mutation_p.G323E			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	0							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GGTGGAGCAGGAAGCCACCGC	0.592000													33	154					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10132227	10132227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:10132227C>T	ENST00000324907.9	+	11	1550	c.1414C>T	c.(1414-1416)Ctc>Ttc	p.L472F	GRHL1_ENST00000324883.5_Missense_Mutation_p.L283F|GRHL1_ENST00000405379.2_Missense_Mutation_p.L472F	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	472					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TCAGCCTGTCCTCTTCATTCC	0.483000													13	50					0	0	1	0	0
TMCO5A	145942	broad.mit.edu	37	15	38234401	38234401	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:38234401G>A	ENST00000558158.1	+	9	668	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	TMCO5A_ENST00000319669.4_Missense_Mutation_p.E172K|TMCO5A_ENST00000540944.1_Missense_Mutation_p.E172K|TMCO5A_ENST00000559502.1_Missense_Mutation_p.E172K			Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	172						integral to membrane				central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	15						GAAGTACCAGGAAACGTTGAA	0.368000													65	140					0	0	1	0	0
SECTM1	6398	broad.mit.edu	37	17	80285043	80285043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80285043G>A	ENST00000269389.3	-	2	424	c.74C>T	c.(73-75)tCc>tTc	p.S25F	SECTM1_ENST00000580437.1_Missense_Mutation_p.S25F	NM_003004.2	NP_002995.1	Q8WVN6	SCTM1_HUMAN	secreted and transmembrane 1	25					immune response|mesoderm development|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular space|Golgi apparatus|integral to membrane|plasma membrane	cytokine activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(1)	4	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			AGCACTCAAGGAGGCAGCCAA	0.667000													5	16					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47882633	47882633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47882633G>A	ENST00000289672.2	-	34	5422	c.5372C>T	c.(5371-5373)tCc>tTc	p.S1791F		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1791					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GCCCGGCAGGGAAGCTTCTTG	0.473000													7	43					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96014663	96014663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96014663C>T	ENST00000260766.3	+	11	4045	c.3411C>T	c.(3409-3411)atC>atT	p.I1137I	PLCE1_ENST00000371380.2_Silent_p.I1137I|PLCE1_ENST00000371375.1_Silent_p.I829I|PLCE1_ENST00000371385.3_Silent_p.I829I	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1137					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TGAATGCCATCGCTAACCCTC	0.522000													109	255					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160921009	160921009	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160921009C>T	ENST00000368029.3	-	4	322	c.265G>A	c.(265-267)Ggc>Agc	p.G89S		NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	89	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTCCAGCCGCCACCCCCAGAA	0.577000													23	61					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59373296	59373296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:59373296C>T	ENST00000348370.4	+	8	2543	c.2110C>T	c.(2110-2112)Cct>Tct	p.P704S	RNF111_ENST00000559209.1_Missense_Mutation_p.P704S|RNF111_ENST00000557998.1_Missense_Mutation_p.P704S|RNF111_ENST00000561186.1_Missense_Mutation_p.P704S|RNF111_ENST00000434298.1_Missense_Mutation_p.P704S	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	704	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		AACATCTCATCCTGTGGCACC	0.507000													22	165					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402857	124402857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124402857C>T	ENST00000338354.3	+	53	7291	c.7185C>T	c.(7183-7185)gtC>gtT	p.V2395V	DMBT1_ENST00000344338.3_Silent_p.V2385V|DMBT1_ENST00000368955.3_Silent_p.V2385V|DMBT1_ENST00000359586.6_Silent_p.V1115V|DMBT1_ENST00000330163.4_Silent_p.V1767V|DMBT1_ENST00000368956.2_Silent_p.V1767V|DMBT1_ENST00000368909.3_Silent_p.V2395V			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2395					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding	p.V2395V(3)|p.V2524V(2)		breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AGGTGGACGTCGTCCTGGGTC	0.647000													9	48					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609371	84609371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84609371G>A	ENST00000344803.2	+	4	4033	c.3986G>A	c.(3985-3987)gGg>gAg	p.G1329E		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AAGACATCAGGGGAGGTGCTT	0.507000													4	23					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854106	12854106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12854106G>A	ENST00000332296.7	+	3	433	c.330G>A	c.(328-330)gaG>gaA	p.E110E		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	110										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATGTTGACGAGAATTTCTGGG	0.542000													129	598					0	0	1	0	0
CHGA	1113	broad.mit.edu	37	14	93390581	93390581	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93390581G>A	ENST00000216492.5	+	2	364	c.84G>A	c.(82-84)ggG>ggA	p.G28G	CHGA_ENST00000334654.4_Silent_p.G28G|CHGA_ENST00000553866.1_Intron	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	28					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		TGAATAAAGGGGATACCGAGG	0.562000													9	19					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799331	45799331	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45799331C>T	ENST00000553795.1	-	4	848	c.540G>A	c.(538-540)ctG>ctA	p.L180L	OR13A1_ENST00000536058.1_Silent_p.L180L|OR13A1_ENST00000374401.2_Silent_p.L180L	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						AGCGCAGCATCAGCCCCGTGT	0.597000													27	58					0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76715603	76715603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76715603G>A	ENST00000264917.5	+	19	2186	c.2141G>A	c.(2140-2142)cGa>cAa	p.R714Q	PDE8B_ENST00000346042.3_Missense_Mutation_p.R617Q|PDE8B_ENST00000505283.1_Missense_Mutation_p.R179Q|PDE8B_ENST00000342343.4_Missense_Mutation_p.R694Q|PDE8B_ENST00000340978.3_Missense_Mutation_p.R667Q|PDE8B_ENST00000333194.4_Missense_Mutation_p.R659Q	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	714	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		AACCATTATCGAACGCTGCGC	0.413000													28	66					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116857374	116857374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116857374G>A	ENST00000374118.3	-	8	871	c.634C>T	c.(634-636)Cct>Tct	p.P212S	KIF12_ENST00000473174.1_5'UTR	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	345	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						AGAGTCTCAGGAAGGCACTGG	0.647000													10	47					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98155765	98155765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98155765C>T	ENST00000357947.3	-	12	1622	c.1397G>A	c.(1396-1398)gGa>gAa	p.G466E	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	466	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GTTCATGTCTCCCCCGCAGGT	0.537000											OREG0020398	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	79					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467432	74467432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74467432C>T	ENST00000249842.3	+	2	590	c.233C>T	c.(232-234)tCg>tTg	p.S78L	ISLR_ENST00000395118.1_Missense_Mutation_p.S78L|RP11-665J16.1_ENST00000561647.1_RNA	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	78					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						CTGCTGCAGTCGCTGTGGCTG	0.647000													9	91					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	10973801	10973801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:10973801C>T	ENST00000304623.8	-	22	3631	c.3442G>A	c.(3442-3444)Gag>Aag	p.E1148K	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.E811K|CTNND2_ENST00000511377.1_Missense_Mutation_p.E1057K|CTNND2_ENST00000458100.2_Missense_Mutation_p.E715K|CTNND2_ENST00000359640.2_Missense_Mutation_p.E1090K	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1148					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CTGCTGGGCTCCTGTGGGACT	0.537000													22	49					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10416277	10416277	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10416277G>A	ENST00000226207.5	-	10	905	c.811C>T	c.(811-813)Ctg>Ttg	p.L271L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	271	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GACTTCTCCAGAAGATCTGCA	0.383000													10	16					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85486685	85486685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85486685G>A	ENST00000394573.1	+	16	1793	c.1591G>A	c.(1591-1593)Gaa>Aaa	p.E531K	SLC28A1_ENST00000537624.1_Missense_Mutation_p.E531K|SLC28A1_ENST00000537216.1_Intron|SLC28A1_ENST00000538177.1_Missense_Mutation_p.E365K|SLC28A1_ENST00000286749.3_Missense_Mutation_p.E531K	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	531					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGTCAGAGCTGAAGTCCTCAC	0.537000													16	68					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17084762	17084762	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17084762G>A	ENST00000455405.2	-	0	254																											CTTTACTAGAGACCCCGCGCA	0.572000													8	34					0	0	1	0	0
CATSPER3	347732	broad.mit.edu	37	5	134343727	134343727	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134343727C>T	ENST00000282611.6	+	4	659	c.573C>T	c.(571-573)ttC>ttT	p.F191F		NM_178019.2	NP_821138.1	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	191					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGTACATCTTCGCTATCTTGG	0.557000													28	86					0	0	1	0	0
FMO5	2330	broad.mit.edu	37	1	146684103	146684103	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:146684103C>T	ENST00000254090.4	-	5	876	c.487_splice	c.e5-1	p.G163_splice	FMO5_ENST00000465173.1_5'UTR|FMO5_ENST00000441068.2_Splice_Site_p.G163_splice|FMO5_ENST00000369272.3_Splice_Site_p.G163_splice	NM_001461.2	NP_001452.2	P49326	FMO5_HUMAN	flavin containing monooxygenase 5	163						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	25	all_hematologic(923;0.0487)					CTTCTCAATTCCTGCAAGAGA	0.353000													10	113					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38320157	38320157	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38320157C>T	ENST00000264645.7	+	7	1435	c.1209C>T	c.(1207-1209)tcC>tcT	p.S403S		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	403	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						AGAAGAAATCCTATTCCCGGG	0.567000													20	120					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839329	62839329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62839329G>A	ENST00000536311.1	+	7	1144	c.780G>A	c.(778-780)gaG>gaA	p.E260E	MYT1_ENST00000328439.1_Silent_p.E260E|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	260	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					ACgaagaggaggacgaggagg	0.592000													5	9					0	0	1	0	0
NOG	9241	broad.mit.edu	37	17	54672217	54672217	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54672217G>A	ENST00000332822.4	+	1	1158	c.633G>A	c.(631-633)ggG>ggA	p.G211G		NM_005450.4	NP_005441.1	Q13253	NOGG_HUMAN	noggin	211					BMP signaling pathway|cartilage development|cell differentiation in hindbrain|dorsal/ventral pattern formation|embryonic digit morphogenesis|embryonic skeletal joint morphogenesis|epithelial to mesenchymal transition|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|middle ear morphogenesis|negative regulation of astrocyte differentiation|negative regulation of BMP signaling pathway|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of cytokine activity|negative regulation of osteoblast differentiation|osteoblast differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|somatic stem cell maintenance|wound healing	extracellular space	cytokine binding|protein homodimerization activity			ovary(1)	1	Breast(9;5.24e-08)					AGCGGCGCGGGGGCCAGCGCT	0.672000													3	12					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9990017	9990017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:9990017G>A	ENST00000256190.8	-	14	1608	c.1471C>T	c.(1471-1473)Ctt>Ttt	p.L491F		NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	491					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GGGAAAGGAAGAATATGAACT	0.413000													52	235					0	0	1	0	0
PDXK	8566	broad.mit.edu	37	21	45152423	45152423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45152423C>T	ENST00000327574.4	+	2	515	c.165C>T	c.(163-165)ccC>ccT	p.P55P	PDXK_ENST00000291565.4_Intron|PDXK_ENST00000468090.1_Intron|PDXK_ENST00000398081.1_Intron|PDXK_ENST00000476313.1_Intron			O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	114					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	TTTGCCAGCCCCAAAGGATTA	0.453000													44	124					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22893441	22893441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22893441C>T	ENST00000543184.1	-	3	954	c.92G>A	c.(91-93)gGg>gAg	p.G31E	PRAME_ENST00000398743.2_Missense_Mutation_p.G31E|PRAME_ENST00000402697.1_Missense_Mutation_p.G31E|PRAME_ENST00000398741.1_Missense_Mutation_p.G31E|PRAME_ENST00000405655.3_Missense_Mutation_p.G31E|PRAME_ENST00000406503.1_Missense_Mutation_p.G31E|PRAME_ENST00000539862.1_Missense_Mutation_p.G15E|PRAME_ENST00000424204.2_Missense_Mutation_p.G15E|PRAME_ENST00000485532.1_5'UTR	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	31					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		CAGGCTCTGCCCTGCCAGCTC	0.592000													33	198					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175063316	175063316	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175063316G>A	ENST00000239462.4	+	7	1628	c.1515G>A	c.(1513-1515)gaG>gaA	p.E505E		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	505	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGCCAGGAGAGGCATACAAGG	0.542000													15	44					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74714293	74714293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74714293C>T	ENST00000373032.3	-	1	243	c.151G>A	c.(151-153)Gat>Aat	p.D51N		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	51					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					AGAAAAGAATCGAAGTAGCTA	0.537000													71	179					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7401451	7401451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7401451C>T	ENST00000322644.6	+	8	1656	c.1257C>T	c.(1255-1257)atC>atT	p.I419I	POLR2A_ENST00000572844.1_Silent_p.I419I	NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	419					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				CCAAGTACATCATCCGAGACA	0.537000													32	47					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77442628	77442628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77442628G>A	ENST00000359047.2	-	7	1144	c.907C>T	c.(907-909)Ccc>Tcc	p.P303S	TRPM6_ENST00000376864.4_Intron|TRPM6_ENST00000361255.3_Intron|TRPM6_ENST00000451710.3_Intron|TRPM6_ENST00000360774.1_Intron|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Intron|TRPM6_ENST00000483186.1_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	0					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GATGGTCAGGGAAGACCATGA	0.557000													11	19					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158548779	158548779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158548779C>T	ENST00000368150.1	-	1	910	c.911G>A	c.(910-912)aGc>aAc	p.S304N		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					ATTCCTCAGGCTGAATATGAT	0.413000													60	126					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827087	96827087	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96827087C>T	ENST00000371270.3	-	3	453	c.359G>A	c.(358-360)tGg>tAg	p.W120*	CYP2C8_ENST00000535898.1_Nonsense_Mutation_p.W18*|CYP2C8_ENST00000539050.1_Nonsense_Mutation_p.W34*	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	120					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GATCTCCTTCCATCTCTTTCC	0.488000													45	77					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469482	10469482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10469482G>A	ENST00000382483.3	-	4	2349	c.2126C>T	c.(2125-2127)tCg>tTg	p.S709L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	709					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTGGTGCTCGATGAGCTTCC	0.617000													15	37					0	0	1	0	0
LIAS	11019	broad.mit.edu	37	4	39469178	39469178	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39469178C>T	ENST00000261434.3	+	7	767	c.649C>T	c.(649-651)Cga>Tga	p.R217*	LIAS_ENST00000340169.2_Nonsense_Mutation_p.R217*|LIAS_ENST00000513731.1_Nonsense_Mutation_p.R87*|LIAS_ENST00000381846.1_Intron	NM_006859.2	NP_006850.2	O43766	LIAS_HUMAN	lipoic acid synthetase	217					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)|ovary(2)	12					Lipoic Acid(DB00166)	TCCTGATTTTCGAGGTGATCT	0.393000													47	98					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19725294	19725294	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:19725294C>T	ENST00000284885.3	-	10	1130	c.1097G>A	c.(1096-1098)tGg>tAg	p.W366*		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	366	MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						AATCCTTTCCCATTCATTATC	0.348000													40	152					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35802909	35802909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35802909G>A	ENST00000361922.4	+	10	1855	c.1705G>A	c.(1705-1707)Gag>Aag	p.E569K	MAG_ENST00000593348.1_3'UTR|MAG_ENST00000392213.3_Missense_Mutation_p.E569K|MAG_ENST00000537831.2_Missense_Mutation_p.E544K	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	569					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TGGGGCACCAGAGAAGTACGA	0.637000													3	19					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76382131	76382131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:76382131G>A	ENST00000357063.3	+	11	3128	c.1868G>A	c.(1867-1869)aGt>aAt	p.S623N	LMO7_ENST00000377534.3_Missense_Mutation_p.S623N|LMO7_ENST00000321797.8_Missense_Mutation_p.S338N|LMO7_ENST00000526202.1_Intron|LMO7_ENST00000341547.4_Intron|LMO7_ENST00000465261.2_Missense_Mutation_p.S338N			Q8WWI1	LMO7_HUMAN	LIM domain 7	623						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AAAGAAAAAAGTAATAGCTGT	0.443000													23	52					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56638911	56638911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56638911G>A	ENST00000267116.7	-	22	2589	c.2468C>T	c.(2467-2469)cCc>cTc	p.P823L		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	823							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						AGGAGTGAAGGGGTTTCCTTC	0.507000													10	157					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651583	84651583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84651583G>A	ENST00000286744.5	+	21	3427	c.3203G>A	c.(3202-3204)gGa>gAa	p.G1068E	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G1068E	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1068						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			AATTCTGCAGGAAGCACCAAC	0.428000													27	101					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21459852	21459852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21459852C>T	ENST00000307378.6	-	6	1126	c.406G>A	c.(406-408)Gga>Aga	p.G136R	SLCO1A2_ENST00000452078.1_Missense_Mutation_p.G136R|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.G4R|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.G134R|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.G4R	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	136					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						ATCTGGGTTCCATTTTCCATA	0.358000													11	54					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70954694	70954694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70954694G>A	ENST00000334414.6	-	17	4233	c.4189C>T	c.(4189-4191)Ctc>Ttc	p.L1397F	PTPRB_ENST00000550358.1_Missense_Mutation_p.L1309F|PTPRB_ENST00000551525.1_Missense_Mutation_p.L1396F|PTPRB_ENST00000261266.5_Missense_Mutation_p.L1179F|PTPRB_ENST00000451516.2_Missense_Mutation_p.L1089F|PTPRB_ENST00000538708.1_Missense_Mutation_p.L1089F|PTPRB_ENST00000550857.1_Missense_Mutation_p.L1089F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1179	Fibronectin type-III 16.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GACCCCCTGAGATGACTCACA	0.453000													51	88					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49433061	49433061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49433061G>A	ENST00000299191.3	+	5	787	c.670G>A	c.(670-672)Gag>Aag	p.E224K		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	224										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						GTTATCCAAGGAGAACATTCG	0.438000													12	87					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280766	152280766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152280766G>A	ENST00000368799.1	-	3	6631	c.6596C>T	c.(6595-6597)tCa>tTa	p.S2199L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2199	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCATCTCCTGATTGTTCCTT	0.542000									Ichthyosis				174	395					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632848	143632848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143632848G>A	ENST00000408955.2	+	1	590	c.523G>A	c.(523-525)Gat>Aat	p.D175N		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CAAGTTTATTGATCACATATC	0.498000													31	72					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383284	108383284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:108383284C>T	ENST00000265843.4	-	6	3060	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K	EXPH5_ENST00000428840.1_Missense_Mutation_p.E908K|EXPH5_ENST00000443411.1_Missense_Mutation_p.E796K|EXPH5_ENST00000525344.1_Missense_Mutation_p.E977K	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	984					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTTAACTTTTCAATACAGGAT	0.378000													27	109					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198665886	198665886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:198665886C>T	ENST00000367376.2	+	4	311	c.140C>T	c.(139-141)cCc>cTc	p.P47L	PTPRC_ENST00000352140.3_Missense_Mutation_p.P47L|PTPRC_ENST00000348564.6_Intron|PTPRC_ENST00000442510.2_Missense_Mutation_p.P49L|PTPRC_ENST00000391970.3_Intron|PTPRC_ENST00000594404.1_Intron	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	47					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TCAAGTGACCCCTTACCTACT	0.418000													23	135					0	0	1	0	0
SERPINB5	5268	broad.mit.edu	37	18	61156597	61156597	+	Silent	SNP	G	G	A	rs141561710	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61156597G>A	ENST00000382771.4	+	4	616	c.324G>A	c.(322-324)acG>acA	p.T108T	SERPINB5_ENST00000489441.1_Silent_p.T108T	NM_002639.4	NP_002630.2	P36952	SPB5_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 5	108					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						TCAGCTCTACGAAGAGACCGT	0.353000													8	64					0	0	1	0	0
TRBV6-9	28598	broad.mit.edu	37	7	142104269	142104269	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142104269G>A	ENST00000390379.1	-	0	195																											ACTGAGTAATGAATGCGCCTC	0.517000													89	181					0	0	1	0	0
OR8D4	338662	broad.mit.edu	37	11	123777309	123777309	+	Silent	SNP	C	C	T	rs79929702		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123777309C>T	ENST00000321355.2	+	1	201	c.171C>T	c.(169-171)acC>acT	p.T57T		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		AACTTCATACCCCCATGTACT	0.398000													43	152					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10247785	10247785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10247785G>A	ENST00000340748.4	-	36	4652	c.4417C>T	c.(4417-4419)Cgt>Tgt	p.R1473C	DNMT1_ENST00000540357.1_Missense_Mutation_p.R1473C|DNMT1_ENST00000359526.4_Missense_Mutation_p.R1489C			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	1473	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CAGACCCCACGGAGGGCCCCA	0.647000													7	10					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98351054	98351054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98351054G>A	ENST00000264972.5	+	9	1176	c.961G>A	c.(961-963)Gac>Aac	p.D321N	ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000442208.1_Missense_Mutation_p.D195N|ZAP70_ENST00000451498.2_Missense_Mutation_p.D14N	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	321	Interdomain B.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						CCCCTACAGCGACCCAGAGGA	0.587000													26	76					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56139282	56139282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56139282C>T	ENST00000319441.4	+	7	1183	c.1019C>T	c.(1018-1020)tCa>tTa	p.S340L	PCK1_ENST00000543666.1_Missense_Mutation_p.S23L|PCK1_ENST00000535860.1_Missense_Mutation_p.S208L	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	340					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCTGGGACTTCAGTGAAGACC	0.507000													31	61					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99725409	99725409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99725409G>A	ENST00000393483.3	-	7	941	c.97C>T	c.(97-99)Cgt>Tgt	p.R33C	TSGA10_ENST00000542655.1_Missense_Mutation_p.R33C|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000355053.4_Missense_Mutation_p.R33C|TSGA10_ENST00000410001.1_Missense_Mutation_p.R33C|TSGA10_ENST00000539964.1_Missense_Mutation_p.R33C	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	33					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						AGTTCTTCACGATCTCTTGTT	0.343000													8	41					0	0	1	0	0
SLC22A20	440044	broad.mit.edu	37	11	64981640	64981640	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64981640C>T	ENST00000525437.1	+	0	330							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						GCCCCAACTCCTCCATCCCGG	0.682000													3	2					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242054730	242054730	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242054730G>A	ENST00000403638.3	-	13	3262	c.3171C>T	c.(3169-3171)tcC>tcT	p.S1057S	PASK_ENST00000539818.1_Silent_p.S841S|PASK_ENST00000544142.1_Silent_p.S871S|PASK_ENST00000358649.4_Silent_p.S1057S|PASK_ENST00000405260.1_Silent_p.S1057S|PASK_ENST00000234040.4_Silent_p.S1057S	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	1057	Protein kinase.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCTCCACCCTGGATAGAATTG	0.423000													42	69					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43012707	43012707	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43012707G>A	ENST00000587309.1	-	3	414	c.391C>T	c.(391-393)Ctg>Ttg	p.L131L	KIF18B_ENST00000593135.1_Silent_p.L131L|KIF18B_ENST00000590129.1_Silent_p.L140L|KIF18B_ENST00000438933.2_Silent_p.L131L|KIF18B_ENST00000339151.4_Silent_p.L131L	NM_001264573.1	NP_001251503.1			kinesin family member 18B											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				ACGGTGGTCAGGTACATGATG	0.642000													15	28					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155719196	155719196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155719196G>A	ENST00000510397.1	+	3	564	c.385G>A	c.(385-387)Ggg>Agg	p.G129R	RBM46_ENST00000281722.3_Missense_Mutation_p.G129R|RBM46_ENST00000514866.1_Missense_Mutation_p.G129R	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	129	RRM 1.						nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				AATTCGACCAGGGAAGTTTAT	0.328000													28	72					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121947613	121947613	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121947613G>A	ENST00000377069.4	-	11	1717	c.1311C>T	c.(1309-1311)ttC>ttT	p.F437F	KDM2B_ENST00000536437.1_Silent_p.F351F|KDM2B_ENST00000377071.4_Silent_p.F468F|KDM2B_ENST00000538046.2_Silent_p.F378F	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	468					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						TCCTTTTGAGGAATCGCAGGG	0.612000													13	71					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28282549	28282549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28282549G>A	ENST00000373894.3	+	7	1152	c.961G>A	c.(961-963)Gcc>Acc	p.A321T	SMPDL3B_ENST00000549094.1_Missense_Mutation_p.A273T|SMPDL3B_ENST00000373888.4_Missense_Mutation_p.A321T|RP11-460I13.2_ENST00000448015.1_RNA	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	321					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		CAACAATCCAGCCATCCGGGT	0.567000													14	55					0	0	1	0	0
CD300C	10871	broad.mit.edu	37	17	72540995	72540995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72540995G>A	ENST00000330793.1	-	2	513	c.153C>T	c.(151-153)acC>acT	p.T51T		NM_006678.3	NP_006669.1	Q08708	CLM6_HUMAN	CD300c molecule	51	Ig-like V-type.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						ATTTGTTGAGGGTCCTGTGTT	0.542000													40	71					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61511339	61511339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61511339C>T	ENST00000257215.5	+	20	2623	c.2507C>T	c.(2506-2508)tCg>tTg	p.S836L		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	836					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		TCCCTGAGCTCGCGCACTGAG	0.672000													99	255					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1457560	1457560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1457560C>T	ENST00000345913.4	+	6	668	c.577C>T	c.(577-579)Ccc>Tcc	p.P193S	TPO_ENST00000497517.2_Intron|TPO_ENST00000349624.3_Missense_Mutation_p.P193S|TPO_ENST00000382198.1_Missense_Mutation_p.P193S|TPO_ENST00000337415.3_Missense_Mutation_p.P193S|TPO_ENST00000382201.3_Missense_Mutation_p.P193S|TPO_ENST00000329066.4_Missense_Mutation_p.P193S|TPO_ENST00000346956.3_Missense_Mutation_p.P193S	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	193					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AGGCTGGAACCCCGGCTTCTT	0.612000													15	68					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157562	22157562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22157562C>T	ENST00000397126.4	-	4	422	c.274G>A	c.(274-276)Gaa>Aaa	p.E92K	ZNF208_ENST00000599916.1_Missense_Mutation_p.E92K|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAAGAATCTTCTATGCCCTGC	0.318000													19	41					0	0	1	0	0
SLC23A1	9963	broad.mit.edu	37	5	138716319	138716319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:138716319C>T	ENST00000353963.3	-	5	438	c.400G>A	c.(400-402)Gag>Aag	p.E134K	SLC23A1_ENST00000503919.1_5'UTR|SLC23A1_ENST00000348729.3_Missense_Mutation_p.E134K	NM_152685.3	NP_689898.2	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 1	134					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(5)|ovary(1)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	CCGTAGATCTCCTCTGGGGGT	0.567000													25	45					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230381	36230381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36230381G>A	ENST00000303965.4	-	2	1217	c.728C>T	c.(727-729)tCc>tTc	p.S243F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	243					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AAAGAATGGGGATGGTGGTGA	0.393000													49	110					0	0	1	0	0
CRISP1	167	broad.mit.edu	37	6	49806191	49806191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49806191G>A	ENST00000335847.4	-	7	682	c.581C>T	c.(580-582)cCa>cTa	p.P194L	CRISP1_ENST00000505118.1_Missense_Mutation_p.P194L|CRISP1_ENST00000355791.2_Missense_Mutation_p.P194L|CRISP1_ENST00000507853.1_Intron|CRISP1_ENST00000329411.5_Intron|CRISP1_ENST00000536021.1_Intron	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	194					fusion of sperm to egg plasma membrane	extracellular space		p.P194L(1)		endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					GGCTTCACATGGGACGCCTGT	0.363000													9	130					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228461637	228461637	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228461637C>A	ENST00000570156.2	+	22	6503	c.6429C>A	c.(6427-6429)gcC>gcA	p.A2143A	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Silent_p.A1768A|OBSCN_ENST00000284548.11_Silent_p.A1768A|RP5-1139B12.2_ENST00000602517.1_RNA|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000359599.6_Silent_p.A615A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1123	Ig-like 21.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ATGAGACAGCCAGCCAGGGGG	0.657000													4	12					0.00909568	0.00909849	1	1	0
TECTA	7007	broad.mit.edu	37	11	120998597	120998597	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120998597C>T	ENST00000392793.1	+	9	2182	c.1911C>T	c.(1909-1911)ttC>ttT	p.F637F	TECTA_ENST00000264037.2_Silent_p.F637F			O75443	TECTA_HUMAN	tectorin alpha	637	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACCAGGGCTTCGTCCTCAGCA	0.657000													23	70					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44687287	44687287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44687287C>T	ENST00000222673.5	+	4	488	c.446C>T	c.(445-447)cCc>cTc	p.P149L	OGDH_ENST00000543843.1_Intron|OGDH_ENST00000439616.2_Intron|OGDH_ENST00000449767.1_Intron|OGDH_ENST00000447398.1_Intron|OGDH_ENST00000443864.2_Missense_Mutation_p.P149L|OGDH_ENST00000444676.1_Missense_Mutation_p.P149L	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	149					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	CAGCTGGACCCCCTGGGGATT	0.522000													26	53					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56244007	56244007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56244007G>A	ENST00000332836.2	-	2	1217	c.1190C>T	c.(1189-1191)gCt>gTt	p.A397V		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	397	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TGCAGCCAAAGCACACAGGCT	0.453000													56	127					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44102463	44102463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44102463G>A	ENST00000259746.9	+	2	325	c.142G>A	c.(142-144)Gac>Aac	p.D48N	TMEM63B_ENST00000323267.6_Missense_Mutation_p.D48N			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	48						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			GCTGGCTCTCGACTTCATGTG	0.602000													27	65					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157804377	157804377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157804377C>T	ENST00000368174.4	-	4	634	c.538G>A	c.(538-540)Gga>Aga	p.G180R		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	180	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTCCCACATCCCAGCTGCCGG	0.587000													24	86					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102334726	102334726	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:102334726G>A	ENST00000395065.3	-	13	1226	c.1125C>T	c.(1123-1125)tcC>tcT	p.S375S	NXF3_ENST00000425644.1_Silent_p.S47S|NXF3_ENST00000497850.1_5'UTR	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	375	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						GAATGCTCAGGGAGAAGCAGG	0.547000													47	39					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190437675	190437675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:190437675G>A	ENST00000261024.2	-	4	710	c.284C>T	c.(283-285)tCg>tTg	p.S95L		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	95					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			TACCACCAGCGAGGTCTGGGC	0.413000													15	67					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118351283	118351283	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118351283G>A	ENST00000528052.1	+	3	121	c.49_splice	c.e3-1	p.G17_splice	PNLIPRP1_ENST00000358834.4_Splice_Site_p.G17_splice|PNLIPRP1_ENST00000480870.2_3'UTR|PNLIPRP1_ENST00000534537.1_Splice_Site_p.G17_splice|PNLIPRP1_ENST00000442761.1_Splice_Site_p.G17_splice			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	17					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		TTCTCTGTAGGAAAAGAAGTT	0.537000													41	109					0	0	1	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60351455	60351455	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60351455C>T	ENST00000602932.1	-	2	236	c.206G>A	c.(205-207)gGg>gAg	p.G69E	TBC1D3P2_ENST00000581291.1_RNA																							CACCAACTACCCGCGACCTCT	0.542000													119	474					0	0	1	0	0
PDLIM1	9124	broad.mit.edu	37	10	97006991	97006991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97006991G>A	ENST00000329399.6	-	5	774	c.666C>T	c.(664-666)atC>atT	p.I222I	PDLIM1_ENST00000477757.1_5'UTR	NM_020992.2	NP_066272.1	O00151	PDLI1_HUMAN	PDZ and LIM domain 1	222					response to oxidative stress	cytoplasm|cytoskeleton	zinc ion binding			endometrium(1)|large_intestine(5)|lung(1)|ovary(1)|skin(2)	10		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CAGACTCCAGGATTTCCTGCA	0.453000													49	94					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222696018	222696018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:222696018C>T	ENST00000343410.6	-	9	2158	c.2100G>A	c.(2098-2100)agG>agA	p.R700R	HHIPL2_ENST00000473144.1_5'UTR	NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	700					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		TCAGGCTCTTCCTCCTCTTGC	0.572000													110	298					0	0	1	0	0
ALPP	250	broad.mit.edu	37	2	233245010	233245010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233245010G>A	ENST00000392027.2	+	6	1041	c.772G>A	c.(772-774)Gaa>Aaa	p.E258K	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	258						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TCTGGTGCAGGAATGGCTGGC	0.647000													31	97					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18276413	18276413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:18276413G>A	ENST00000377369.2	+	7	1375	c.1102G>A	c.(1102-1104)Ggc>Agc	p.G368S	SLC39A12_ENST00000377371.3_Missense_Mutation_p.G368S|SLC39A12_ENST00000377374.4_Missense_Mutation_p.G368S|SLC39A12_ENST00000539911.1_Missense_Mutation_p.G234S	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	368					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						CTTAGAATACGGCTACAGCAC	0.522000													26	49					0	0	1	0	0
IGHG3	3502	broad.mit.edu	37	14	106237723	106237723	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106237723C>T	ENST00000390551.2	-	0	19																											GGGGGAAGACCGATGGGCCCT	0.662000													6	46					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94049587	94049587	+	Missense_Mutation	SNP	C	C	T	rs139199272		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94049587C>T	ENST00000297268.6	+	35	2593	c.2122C>T	c.(2122-2124)Cgg>Tgg	p.R708W		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	708			Missing (in OI2A).|R -> Q (in Marfan syndrome).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	tgctggtcctCGGGGAAGCCC	0.448000										HNSCC(75;0.22)			27	91					0	0	1	0	0
UBE2E2	7325	broad.mit.edu	37	3	23541152	23541152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:23541152C>T	ENST00000396703.1	+	4	461	c.281C>T	c.(280-282)cCc>cTc	p.P94L	UBE2E2_ENST00000425792.1_Missense_Mutation_p.P94L	NM_152653.3	NP_689866.1	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	94					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(2)	10						ATATTGGGACCCCCAGGATCT	0.398000													16	73					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8115917	8115917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:8115917G>A	ENST00000379328.3	+	6	1834	c.1266G>A	c.(1264-1266)ccG>ccA	p.P422P	GATA3_ENST00000346208.3_Silent_p.P421P|GATA3_ENST00000461472.1_3'UTR	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	421					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding	p.P422P(1)		NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CGCCCACGCCGATGCACCCGC	0.647000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						28	71					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35044528	35044528	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35044528A>G	ENST00000312292.5	+	2	1949	c.1902A>G	c.(1900-1902)gaA>gaG	p.E634E	C9orf131_ENST00000421362.2_Silent_p.E586E|C9orf131_ENST00000354479.5_Silent_p.E561E	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	634										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AGCAAAAAGAAAACTGTGTTC	0.498000													23	162					0	0	1	0	0
NRN1	51299	broad.mit.edu	37	6	6006945	6006945	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6006945A>C	ENST00000244766.2	-	1	255	c.38T>G	c.(37-39)aTc>aGc	p.I13S		NM_016588.2	NP_057672.1	Q9NPD7	NRN1_HUMAN	neuritin 1	13						anchored to membrane|plasma membrane				endometrium(2)|large_intestine(2)|lung(4)	8	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		CACCGCGAGGATCAGTGAAAT	0.577000													42	97					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13793685	13793685	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13793685C>T	ENST00000265104.4	-	49	8267	c.8163G>A	c.(8161-8163)aaG>aaA	p.K2721K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2721	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGAACTGCCTCTTGAGTCTTT	0.498000									Kartagener syndrome				50	123					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51362271	51362271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:51362271C>T	ENST00000522124.1	+	6	924	c.263C>T	c.(262-264)tCc>tTc	p.S88F	SNTG1_ENST00000517473.1_Missense_Mutation_p.S88F|SNTG1_ENST00000276467.5_Missense_Mutation_p.S88F|SNTG1_ENST00000518864.1_Missense_Mutation_p.S88F	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	88	PDZ.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCAAAAATCTCCAAGGAACAA	0.313000													11	32					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112042662	112042662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112042662G>A	ENST00000241356.4	-	2	1272	c.867C>T	c.(865-867)ttC>ttT	p.F289F	ADORA3_ENST00000369716.4_Intron|ADORA3_ENST00000369717.4_Intron	NM_000677.3	NP_000668.1	P33765	AA3R_HUMAN	adenosine A3 receptor	289					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	AGGTTTCCTTGAACTTCTTTA	0.443000													20	40					0	0	1	0	0
HSPA5	3309	broad.mit.edu	37	9	127998957	127998957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127998957C>T	ENST00000324460.6	-	8	2082	c.1879G>A	c.(1879-1881)Gtt>Att	p.V627I		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	627					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	ATTGGTTGAACAATTTCTTCC	0.423000										Prostate(1;0.17)			24	85					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123725021	123725021	+	Missense_Mutation	SNP	G	G	A	rs138933092		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123725021G>A	ENST00000223642.1	-	36	4461	c.4432C>T	c.(4432-4434)Cgg>Tgg	p.R1478W		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1478					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity	p.R1478W(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCAAATATCCGGAATCGTACA	0.373000													9	136					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31535929	31535929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31535929C>T	ENST00000215885.3	-	1	664	c.412G>A	c.(412-414)Gga>Aga	p.G138R		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	138					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						CCAGGGACTCCACTCTGCCCT	0.617000													10	47					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142724037	142724037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142724037G>A	ENST00000350513.2	-	1	245	c.183C>T	c.(181-183)ttC>ttT	p.F61F		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					GGTGGCTGAGGAAGAAATACA	0.443000													36	105					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50671870	50671870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50671870G>A	ENST00000439308.2	-	3	1483	c.991C>T	c.(991-993)Ctc>Ttc	p.L331F	TUBGCP6_ENST00000248846.5_Missense_Mutation_p.L331F	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	331					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGCAGCTGGAGCTCCCCTTGG	0.647000													8	19					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133150166	133150166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133150166C>T	ENST00000388996.4	-	12	2086	c.1666G>A	c.(1666-1668)Gac>Aac	p.D556N	KCNQ3_ENST00000519445.1_Missense_Mutation_p.D556N|KCNQ3_ENST00000521134.1_Missense_Mutation_p.D436N	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	556					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GAAAGCATGTCGAGATGCCCG	0.453000													20	104					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32716075	32716075	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:32716075G>A	ENST00000357033.4	-	9	1078	c.872C>T	c.(871-873)tCc>tTc	p.S291F	DMD_ENST00000378677.2_Missense_Mutation_p.S287F|DMD_ENST00000288447.4_Missense_Mutation_p.S283F	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	291					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGGCTTAGGGGAAGAAGTTCT	0.512000													11	4					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71471960	71471960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71471960G>A	ENST00000322937.6	+	13	960	c.857G>A	c.(856-858)aGg>aAg	p.R286K	AMBN_ENST00000449493.2_Missense_Mutation_p.R271K	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	286					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			GGAGGCATGAGGCCCGGCTTT	0.537000													23	70					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59373179	59373179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:59373179C>T	ENST00000348370.4	+	8	2426	c.1993C>T	c.(1993-1995)Ccg>Tcg	p.P665S	RNF111_ENST00000559209.1_Missense_Mutation_p.P665S|RNF111_ENST00000557998.1_Missense_Mutation_p.P665S|RNF111_ENST00000561186.1_Missense_Mutation_p.P665S|RNF111_ENST00000434298.1_Missense_Mutation_p.P665S	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	665	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		TTCTGCCTGCCCGCATTCTCA	0.438000													25	161					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	27066599	27066599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:27066599C>T	ENST00000539517.2	-	1	361	c.44G>A	c.(43-45)gGg>gAg	p.G15E	NOVA1_ENST00000574031.1_Missense_Mutation_p.G15E|NOVA1_ENST00000465357.2_Missense_Mutation_p.G15E|NOVA1_ENST00000344429.5_Missense_Mutation_p.G15E|NOVA1_ENST00000267422.7_5'UTR|NOVA1_ENST00000547619.1_Missense_Mutation_p.G15E	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	15					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		TATGGGAACCCCAGTGTGGGT	0.612000													4	13					0	0	1	0	0
ATP13A2	23400	broad.mit.edu	37	1	17318747	17318747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17318747G>A	ENST00000452699.1	-	18	2170	c.1981C>T	c.(1981-1983)Ccc>Tcc	p.P661S	RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000341676.5_Missense_Mutation_p.P661S|ATP13A2_ENST00000326735.8_Missense_Mutation_p.P666S	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	666					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CCTGTCTCGGGGTTGCAGAGC	0.672000													16	25					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144621331	144621331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144621331G>A	ENST00000262577.5	-	2	237	c.206C>T	c.(205-207)tCg>tTg	p.S69L		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	69					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CTTGCGCCACGAAGGCCCATG	0.672000													32	99					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99800315	99800315	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:99800315G>A	ENST00000259470.5	-	2	260	c.11C>T	c.(10-12)tCg>tTg	p.S4L	CTSV_ENST00000479932.1_5'UTR|CTSV_ENST00000538255.1_Missense_Mutation_p.S4L	NM_001333.3	NP_001324.2			cathepsin V																		CAGGACGAGCGAAAGATTCAT	0.413000													23	64					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37451769	37451769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37451769G>A	ENST00000374660.1	+	17	1926	c.1827G>A	c.(1825-1827)ttG>ttA	p.L609L	ANKRD30A_ENST00000361713.1_Silent_p.L609L|ANKRD30A_ENST00000602533.1_Silent_p.L609L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	665						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AACAAACATTGAGAGCAGGTA	0.328000													35	72					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153661465	153661465	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153661465C>T	ENST00000368680.3	+	16	2926	c.2454C>T	c.(2452-2454)tcC>tcT	p.S818S		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	818					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	ACCTGCTGTCCCGCATGGAGC	0.632000													39	154					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15290645	15290645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15290645C>T	ENST00000378116.4	-	5	753	c.747G>A	c.(745-747)caG>caA	p.Q249Q	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	249						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TACCCAGCTTCTGGTCAAACC	0.557000													27	72					0	0	1	0	0
AFP	174	broad.mit.edu	37	4	74308080	74308080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:74308080C>T	ENST00000395792.2	+	5	650	c.550C>T	c.(550-552)Cgc>Tgc	p.R184C	AFP_ENST00000226359.2_Missense_Mutation_p.R184C	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	184	Albumin 1.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTGGGCTGCTCGCTATGACAA	0.373000									Alpha-Fetoprotein, Hereditary Persistence of				13	63					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166785697	166785697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166785697G>A	ENST00000243344.7	-	11	1471	c.1334C>T	c.(1333-1335)cCt>cTt	p.P445L		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	445						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						CAAGAAATCAGGATTTAGCTT	0.343000													18	49					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143633044	143633044	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143633044C>A	ENST00000408955.2	+	1	786	c.719C>A	c.(718-720)aCg>aAg	p.T240K		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					GCCTTCCACACGTGTGCCTCT	0.522000													21	86					7.45023e-12	7.48331e-12	1	1	0
FBXO15	201456	broad.mit.edu	37	18	71796789	71796789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:71796789C>T	ENST00000269500.5	-	5	743	c.408G>A	c.(406-408)atG>atA	p.M136I	FBXO15_ENST00000419743.2_Missense_Mutation_p.M212I	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	136										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		CAACATGCTCCATGATATATT	0.338000													13	46					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27185547	27185547	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27185547C>T	ENST00000380036.4	+	9	1689	c.1247C>T	c.(1246-1248)cCc>cTc	p.P416L	TEK_ENST00000519097.1_Missense_Mutation_p.P269L|TEK_ENST00000406359.4_Missense_Mutation_p.P373L	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	416	Ig-like C2-type 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CGGATCCTCCCCCCTGACTCA	0.423000													36	140					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50741774	50741774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50741774G>A	ENST00000300589.2	+	3	654	c.549G>A	c.(547-549)agG>agA	p.R183R	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	183	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				AGGCAAGAAGGCTGCTTGATC	0.478000													37	84					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6522131	6522131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6522131G>A	ENST00000377782.3	-	9	942	c.875C>T	c.(874-876)cCt>cTt	p.P292L	TNFRSF25_ENST00000356876.3_Missense_Mutation_p.P283L|TNFRSF25_ENST00000351748.3_Missense_Mutation_p.P100L|TNFRSF25_ENST00000348333.3_Missense_Mutation_p.P238L|TNFRSF25_ENST00000351959.5_Missense_Mutation_p.P246L	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	283					apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GGGGTAGCCAGGGGTCCAGCT	0.617000													22	78					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134617988	134617988	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:134617988C>T	ENST00000361388.2	+	5	934	c.468C>T	c.(466-468)cgC>cgT	p.R156R	CALD1_ENST00000361675.2_Silent_p.R156R|CALD1_ENST00000422748.1_Silent_p.R156R|CALD1_ENST00000543443.1_Silent_p.R161R|CALD1_ENST00000393118.2_Silent_p.R150R|CALD1_ENST00000424922.1_Silent_p.R150R|CALD1_ENST00000495522.1_Silent_p.R150R|CALD1_ENST00000417172.1_Silent_p.R156R|CALD1_ENST00000361901.2_Silent_p.R156R	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	369	Myosin and calmodulin-binding (By similarity).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						GTGAAAGTCGCCAAGAAAGAT	0.408000													9	20					0	0	1	0	0
C4orf26	152816	broad.mit.edu	37	4	76489530	76489530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76489530C>T	ENST00000311623.4	+	2	309	c.274C>T	c.(274-276)Cct>Tct	p.P92S	C4orf26_ENST00000435974.2_Silent_p.S106S	NM_001257072.1|NM_178497.3	NP_001244001.1|NP_848592.2	Q17RF5	CD026_HUMAN	chromosome 4 open reading frame 26	92						extracellular region				kidney(1)|large_intestine(4)|stomach(1)	6			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ACCTTTCGTCCCTTCAAGGTG	0.478000													66	178					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73477952	73477952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:73477952C>T	ENST00000377110.2	-	3	577	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	TRPM3_ENST00000360823.2_5'UTR|TRPM3_ENST00000377097.3_5'UTR|TRPM3_ENST00000423814.3_Missense_Mutation_p.E114K|TRPM3_ENST00000396283.1_5'UTR|TRPM3_ENST00000377101.1_5'UTR|TRPM3_ENST00000357533.2_Missense_Mutation_p.E114K|TRPM3_ENST00000377105.1_5'UTR|TRPM3_ENST00000377106.1_5'UTR|TRPM3_ENST00000361823.5_5'UTR|TRPM3_ENST00000437699.3_5'UTR|TRPM3_ENST00000377111.2_Missense_Mutation_p.E112K	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	112						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						AGGCGACTTTCATTTTTCTCA	0.488000													30	104					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28714584	28714584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28714584G>A	ENST00000257197.3	-	12	2088	c.1827C>T	c.(1825-1827)ttC>ttT	p.F609F	DSC1_ENST00000257198.5_Silent_p.F609F|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	609	Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TATCCAGAAAGAATTGAAAAG	0.353000													5	26					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88761493	88761493	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88761493C>T	ENST00000444431.1	+	0	2623				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										ACAATAATATCGTGAGTACAA	0.393000													45	103					0	0	1	0	0
C20orf24	55969	broad.mit.edu	37	20	35240525	35240525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35240525C>T	ENST00000342422.3	+	3	461	c.331C>T	c.(331-333)Cgt>Tgt	p.R111C	C20orf24_ENST00000373852.5_3'UTR|TGIF2-C20orf24_ENST00000558530.1_3'UTR|C20orf24_ENST00000344795.3_3'UTR	NM_199483.2	NP_955777.1			chromosome 20 open reading frame 24											breast(1)|kidney(1)|lung(2)	4	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GGAACTTGATCGTTGGGGAAC	0.512000													45	441					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17088210	17088210	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17088210G>A	ENST00000443236.1	-	15	1898	c.1867C>T	c.(1867-1869)Cag>Tag	p.Q623*	CPAMD8_ENST00000388925.4_Intron	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	576						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						ACTGCAAACTGAAGGCTGTCG	0.602000													28	72					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35974080	35974080	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:35974080G>A	ENST00000297866.5	+	8	1243	c.1177G>A	c.(1177-1179)Gaa>Aaa	p.E393K		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	393										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TTTTACAGGTGAACGATTTCA	0.348000													29	38					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7637888	7637888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7637888C>T	ENST00000572933.1	+	7	2300	c.840C>T	c.(838-840)ttC>ttT	p.F280F	DNAH2_ENST00000570791.1_Silent_p.F280F|DNAH2_ENST00000389173.2_Silent_p.F280F|DNAH2_ENST00000082259.3_Silent_p.F280F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	280	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGATTGAGTTCTGGCGCAACC	0.537000													27	21					0	0	1	0	0
IL36G	56300	broad.mit.edu	37	2	113736882	113736882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113736882G>A	ENST00000259205.4	+	3	209	c.140G>A	c.(139-141)cGa>cAa	p.R47Q	IL36G_ENST00000376489.2_Intron	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	47					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						GCAGTTCCACGAAGTGACAGT	0.493000													11	45					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75227339	75227339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:75227339G>A	ENST00000342232.4	-	2	936	c.896C>T	c.(895-897)tCc>tTc	p.S299F		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	299					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CATGCCATTGGAGCGCTCGCT	0.537000													26	159					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66638892	66638892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66638892G>A	ENST00000393960.1	-	6	662	c.381C>T	c.(379-381)ttC>ttT	p.F127F	PC_ENST00000355677.3_Silent_p.F127F|PC_ENST00000524491.1_Silent_p.F87F|PC_ENST00000393955.2_Silent_p.F127F|PC_ENST00000393958.2_Silent_p.F127F	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	127	Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity	p.F127F(1)		cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AGGCCTGGGCGAAGTCCGCTC	0.632000													23	192					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83182733	83182733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:83182733C>T	ENST00000398309.2	-	19	2537	c.2067G>A	c.(2065-2067)atG>atA	p.M689I	DLG2_ENST00000524982.1_Missense_Mutation_p.M685I|DLG2_ENST00000543673.1_Missense_Mutation_p.M794I|DLG2_ENST00000418306.2_Missense_Mutation_p.M568I|DLG2_ENST00000532653.1_Missense_Mutation_p.M671I|DLG2_ENST00000426717.2_Missense_Mutation_p.M153I|DLG2_ENST00000280241.8_Missense_Mutation_p.M728I|DLG2_ENST00000376106.3_Missense_Mutation_p.M153I|DLG2_ENST00000531015.1_Missense_Mutation_p.M656I|DLG2_ENST00000330014.6_Missense_Mutation_p.M610I|DLG2_ENST00000537455.1_Missense_Mutation_p.M439I|DLG2_ENST00000376104.2_Missense_Mutation_p.M794I|DLG2_ENST00000404783.3_Missense_Mutation_p.M167I	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	689	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCCGATCCTTCATGGGCCCCA	0.433000													23	34					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25272862	25272862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25272862G>A	ENST00000218548.6	+	12	1930	c.1597G>A	c.(1597-1599)Gag>Aag	p.E533K	ATP12A_ENST00000381946.3_Missense_Mutation_p.E527K	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	527					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGGGGCCCCTGAGCGCATCCT	0.562000													34	75					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232556	21232556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21232556C>T	ENST00000233242.1	-	26	7311	c.7184G>A	c.(7183-7185)gGa>gAa	p.G2395E		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2395					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATCAATAAATCCAACCAATTT	0.313000													8	25					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62543093	62543093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:62543093G>A	ENST00000383710.4	-	10	2089	c.1740C>T	c.(1738-1740)acC>acT	p.T580T	CADPS_ENST00000283269.9_Silent_p.T580T|CADPS_ENST00000357948.3_Silent_p.T580T	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	580	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GCTGGGGGTCGGTGTAATCCA	0.517000													29	133					0	0	1	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315777	73315777	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73315777G>A	ENST00000258098.6	-	3	1209	c.969C>T	c.(967-969)gaC>gaT	p.D323D	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	323					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						GGCCCTGAAGGTCCAGAAGGG	0.622000													11	25					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886857	23886857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23886857G>A	ENST00000355349.3	-	31	4370	c.4208C>T	c.(4207-4209)gCc>gTc	p.A1403V		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1403					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGCCTCCACGGCCTCCTCAGC	0.607000													33	50					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7170372	7170372	+	Splice_Site	SNP	G	G	A	rs112283405		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7170372G>A	ENST00000406697.1	+	7	1019		c.e7+1		C1S_ENST00000328916.3_Splice_Site|C1S_ENST00000402681.3_Splice_Site|C1S_ENST00000360817.5_Splice_Site			P09871	C1S_HUMAN	complement component 1, s subcomponent						complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GTTGCCACAGGTAAGGCTCAC	0.423000													23	59					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169791926	169791926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169791926C>T	ENST00000263817.6	-	23	2948	c.2824G>A	c.(2824-2826)Gaa>Aaa	p.E942K		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	942	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTGAGGGCTTCATTTGTAATC	0.448000													61	187					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13363724	13363724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13363724G>A	ENST00000254508.5	-	35	4966	c.4884C>T	c.(4882-4884)ttC>ttT	p.F1628F		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1628					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GCTCCACGGTGAACACATCTT	0.537000													44	100					0	0	1	0	0
EWSR1	2130	broad.mit.edu	37	22	29695762	29695762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29695762C>T	ENST00000397938.2	+	16	2171	c.1852C>T	c.(1852-1854)Cct>Tct	p.P618S	EWSR1_ENST00000414183.2_Missense_Mutation_p.P623S|EWSR1_ENST00000406548.1_Missense_Mutation_p.P617S|EWSR1_ENST00000332035.6_Missense_Mutation_p.P562S|EWSR1_ENST00000331029.7_Missense_Mutation_p.P580S|EWSR1_ENST00000332050.6_Missense_Mutation_p.P545S	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	618	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						ACGAGGTGGCCCTGGGGGGCC	0.597000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								7	8					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41135376	41135376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41135376C>T	ENST00000308370.7	+	34	4793	c.4793C>T	c.(4792-4794)tCc>tTc	p.S1598F	LTBP4_ENST00000243562.9_3'UTR|LTBP4_ENST00000204005.9_Missense_Mutation_p.S1561F|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000545697.1_3'UTR|LTBP4_ENST00000396819.3_Missense_Mutation_p.S1531F	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1599	EGF-like 16.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACGGATGGCTCCTTCCGCTGC	0.701000													23	45					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169826714	169826714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169826714G>A	ENST00000263817.6	-	15	1774	c.1650C>T	c.(1648-1650)acC>acT	p.T550T		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	550	ABC transporter 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTCCAACAAGGGTGTCAAATT	0.463000													6	24					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98513881	98513881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:98513881C>T	ENST00000268042.6	+	7	1272	c.1108C>T	c.(1108-1110)Cct>Tct	p.P370S	ARRDC4_ENST00000538249.1_Missense_Mutation_p.P283S	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	370					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TCCTCCTTACCCTCAACCCCC	0.438000													70	69					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181546989	181546989	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181546989C>T	ENST00000526775.1	+	4	765	c.600C>T	c.(598-600)ctC>ctT	p.L200L	CACNA1E_ENST00000367570.1_Silent_p.L200L|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000360108.3_Silent_p.L200L|CACNA1E_ENST00000357570.5_Silent_p.L151L|CACNA1E_ENST00000358338.5_Silent_p.L151L|CACNA1E_ENST00000367573.2_Silent_p.L200L	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	200					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTTGAAGCTCGTGTCAGGGA	0.537000													8	10					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60476093	60476093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60476093G>A	ENST00000371201.3	-	9	1270	c.1163C>T	c.(1162-1164)tCt>tTt	p.S388F	C1orf87_ENST00000450089.2_Missense_Mutation_p.S159F	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	388							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CAAATCAGAAGAAGCTCTGGT	0.388000													32	72					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003955	34003955	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34003955G>A	ENST00000374181.3	-	8	2101	c.1932C>T	c.(1930-1932)atC>atT	p.I644I	GRM4_ENST00000455714.2_Silent_p.I504I|GRM4_ENST00000535756.1_Silent_p.I511I|GRM4_ENST00000544773.1_Silent_p.I475I|GRM4_ENST00000545715.1_Silent_p.I336I|GRM4_ENST00000374177.3_Silent_p.I528I|GRM4_ENST00000538487.1_Silent_p.I644I	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	644					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CGGGCTCAGCGATCATGAGGA	0.602000													20	38					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138657008	138657008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138657008C>T	ENST00000298480.5	+	12	1241	c.1167C>T	c.(1165-1167)ttC>ttT	p.F389F	KCNT1_ENST00000263604.3_Silent_p.F370F|KCNT1_ENST00000488444.2_Silent_p.F370F|KCNT1_ENST00000371757.2_Silent_p.F389F|KCNT1_ENST00000486577.2_Silent_p.F350F|KCNT1_ENST00000490355.2_Silent_p.F370F|KCNT1_ENST00000487664.1_Silent_p.F344F|KCNT1_ENST00000491806.2_Silent_p.F356F			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	389						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TCATGGACTTCCTGAACGAGT	0.647000													45	85					0	0	1	0	0
GNLY	10578	broad.mit.edu	37	2	85922478	85922478	+	Missense_Mutation	SNP	G	G	A	rs149497301		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:85922478G>A	ENST00000409696.3	+	3	325	c.43G>A	c.(43-45)Gac>Aac	p.D15N	GNLY_ENST00000263863.4_Missense_Mutation_p.D30N|GNLY_ENST00000524600.1_Missense_Mutation_p.D57N|GNLY_ENST00000533041.1_3'UTR	NM_012483.2	NP_036615.2	P22749	GNLY_HUMAN	granulysin	30					cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						TGAGTACTACGACCTGGCAAG	0.622000													16	30					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51287543	51287543	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:51287543G>A	ENST00000395542.2	-	2	324	c.140C>T	c.(139-141)tCg>tTg	p.S47L	COBL_ENST00000441453.1_Missense_Mutation_p.S47L|COBL_ENST00000265136.7_Missense_Mutation_p.S47L|COBL_ENST00000395540.2_Missense_Mutation_p.S47L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	47										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GTTCTGCTGCGACCCGAGGGC	0.627000													26	69					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043912	20043912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20043912G>A	ENST00000570682.1	-	2	507	c.207C>T	c.(205-207)ctC>ctT	p.L69L		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	69						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						CGGCAGCAGCGAGTGCCAAGA	0.473000													17	33					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89391179	89391179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89391179G>A	ENST00000439576.2	+	9	2016	c.1642G>A	c.(1642-1644)Gac>Aac	p.D548N	ACAN_ENST00000558207.1_Missense_Mutation_p.D548N|ACAN_ENST00000352105.7_Missense_Mutation_p.D548N|ACAN_ENST00000559004.1_Missense_Mutation_p.D548N|ACAN_ENST00000561243.1_Missense_Mutation_p.D548N	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	548					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			ATGCGTGGGTGACAAGGACAG	0.587000													35	110					0	0	1	0	0
WDR93	56964	broad.mit.edu	37	15	90255328	90255328	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90255328C>T	ENST00000268130.7	+	5	734	c.633C>T	c.(631-633)ctC>ctT	p.L211L	WDR93_ENST00000560294.1_Silent_p.L211L	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	211					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CAGCCTTCCTCCTACAAGGCA	0.388000													22	43					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31434773	31434773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31434773C>T	ENST00000389202.2	+	25	3009	c.2960C>T	c.(2959-2961)cCa>cTa	p.P987L		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	987					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						ATGGAGGCCCCATCTCAGGTA	0.542000													20	62					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48626319	48626319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48626319C>T	ENST00000006658.6	+	5	630	c.510C>T	c.(508-510)ttC>ttT	p.F170F	SPATA20_ENST00000393244.3_Silent_p.F110F|SPATA20_ENST00000356488.4_Silent_p.F154F|SPATA20_ENST00000511937.1_3'UTR	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	154					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			ACATGACGTTCGTGCAGGTGA	0.627000													12	41					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139396	90139396	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90139396C>T	ENST00000492446.1	+	0	194																											AGCTGGTTAGCCTGGTATCAG	0.527000													55	164					0	0	1	0	0
IGHV3-53	28420	broad.mit.edu	37	14	107048774	107048774	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107048774C>T	ENST00000390627.2	-	0	466																											ATCGGCCCTTCACGGAGTCTG	0.537000													61	412					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139263219	139263219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:139263219C>T	ENST00000395297.1	-	6	577	c.407G>A	c.(406-408)cGa>cAa	p.R136Q		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	136										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCAAGCGTTCGGCTGCTGAC	0.592000										HNSCC(54;0.14)			47	111					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1086331	1086331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1086331G>A	ENST00000441003.2	+	23	3067	c.3040G>A	c.(3040-3042)Gag>Aag	p.E1014K	MUC2_ENST00000359061.5_Missense_Mutation_p.E1014K	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1014	VWFD 3.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGTGAGCAGCGAGCTGGACTT	0.647000													11	15					0	0	1	0	0
ZNF579	163033	broad.mit.edu	37	19	56090169	56090169	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56090169G>A	ENST00000325421.4	-	2	865	c.837C>T	c.(835-837)ttC>ttT	p.F279F		NM_152600.2	NP_689813.2	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		AGGGCCTGGCGAAGGCCTTGA	0.721000													10	27					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802809	185802809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185802809G>A	ENST00000302277.6	+	4	3280	c.2686G>A	c.(2686-2688)Gag>Aag	p.E896K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	896						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGGTGAAACTGAGCATTTAGA	0.403000													28	95					0	0	1	0	0
GSR	2936	broad.mit.edu	37	8	30538495	30538495	+	Missense_Mutation	SNP	G	G	A	rs3180947		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30538495G>A	ENST00000221130.5	-	12	1435	c.1345C>T	c.(1345-1347)Ccg>Tcg	p.P449S	GSR_ENST00000414019.1_Missense_Mutation_p.P406S|GSR_ENST00000541648.1_Missense_Mutation_p.P396S|GSR_ENST00000537535.1_Missense_Mutation_p.P367S|GSR_ENST00000546342.1_Missense_Mutation_p.P420S	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	449					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TGATACATCGGGGTAAAGCTC	0.338000													14	180					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14749142	14749142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14749142G>A	ENST00000253673.5	-	11	1359	c.1259C>T	c.(1258-1260)tCc>tTc	p.S420F	EMR3_ENST00000599900.1_Missense_Mutation_p.S205F|EMR3_ENST00000344373.4_Missense_Mutation_p.S368F|EMR3_ENST00000443157.2_Missense_Mutation_p.S294F	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	420					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						GGCGATGATGGAGCACAGCAC	0.587000													8	36					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767539	57767539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57767539C>T	ENST00000371030.2	+	1	1465	c.1465C>T	c.(1465-1467)Ccc>Tcc	p.P489S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	489						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CCACTCCGTCCCCACTCAGCT	0.701000													19	58					0	0	1	0	0
H2BFWT	158983	broad.mit.edu	37	X	103268164	103268164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:103268164C>T	ENST00000217926.5	-	1	95	c.69G>A	c.(67-69)atG>atA	p.M23I		NM_001002916.3	NP_001002916.2	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	23					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			breast(2)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	16						AGGCAGTGGCCATTAGATGGC	0.617000													13	13					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17675575	17675575	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17675575G>A	ENST00000262077.2	-	4	607	c.608C>T	c.(607-609)tCa>tTa	p.S203L	NUP153_ENST00000537253.1_Missense_Mutation_p.S203L	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	203					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			AGGTGGCAATGAAGTGTTCTT	0.368000													30	56					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179563498	179563498	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179563498G>A	ENST00000393371.2	-	3	614	c.318C>T	c.(316-318)ttC>ttT	p.F106F	RASGEF1C_ENST00000361132.4_Silent_p.F106F|RASGEF1C_ENST00000522500.1_5'UTR			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	106	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTTGGGGCCGAACTTCCGGA	0.682000													4	5					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179399221	179399221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179399221C>T	ENST00000589042.1	-	358	102345	c.102121G>A	c.(102121-102123)Gag>Aag	p.E34041K	TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000589434.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E31473K|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E32400K|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E25168K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E25101K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E24976K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32400	Ig-like 150.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGCTAATCTCTTTGAATGCT	0.428000													36	79					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810929	65810929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65810929G>A	ENST00000312006.4	-	3	626	c.345C>T	c.(343-345)ttC>ttT	p.F115F	GAL3ST3_ENST00000527878.1_Silent_p.F115F	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	115					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						CCGGGTGCACGAAGTGCGCCG	0.692000													4	30					0	0	1	0	0
TNNI2	7136	broad.mit.edu	37	11	1862727	1862727	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1862727C>T	ENST00000381906.1	+	8	564	c.495C>T	c.(493-495)atC>atT	p.I165I	TNNI2_ENST00000381905.3_Silent_p.I165I|TNNI2_ENST00000381911.1_Silent_p.I165I|TNNI2_ENST00000252898.7_Silent_p.I165I	NM_001145829.1	NP_001139301.1	P48788	TNNI2_HUMAN	troponin I type 2 (skeletal, fast)	165					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding			lung(8)|prostate(1)|urinary_tract(1)	10		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GGAAGAACATCGAGGAGAAGT	0.642000													19	53					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102791757	102791757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:102791757G>A	ENST00000504592.1	+	9	1232	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	BANK1_ENST00000322953.4_Missense_Mutation_p.E287K|BANK1_ENST00000444316.2_Missense_Mutation_p.E257K|BANK1_ENST00000428908.1_Missense_Mutation_p.E154K|BANK1_ENST00000508653.1_Missense_Mutation_p.E154K			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	287	DBB.				B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AAAGGCAAAGGAATGCCTATT	0.398000													28	55					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503592	140503592	+	Missense_Mutation	SNP	C	C	T	rs146284769		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140503592C>T	ENST00000194152.1	+	1	2012	c.2012C>T	c.(2011-2013)cCt>cTt	p.P671L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		671					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTACCTGCCTCTCCCTGAG	0.682000													35	153					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233514787	233514787	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233514787C>T	ENST00000366624.3	+	9	2296	c.2035C>T	c.(2035-2037)Cag>Tag	p.Q679*	MLK4_ENST00000366622.1_Nonsense_Mutation_p.Q125*	NM_032435.2	NP_115811.2																					GAAAGATGCTCAGAGAGAGAA	0.463000													43	93					0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50783766	50783766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50783766C>T	ENST00000540145.1	+	4	572	c.157C>T	c.(157-159)Cgt>Tgt	p.R53C	CYLD_ENST00000568704.2_Missense_Mutation_p.R53C|CYLD_ENST00000427738.3_Missense_Mutation_p.R53C|CYLD_ENST00000311559.9_Missense_Mutation_p.R53C|CYLD_ENST00000398568.2_Missense_Mutation_p.R53C|CYLD_ENST00000569418.1_Missense_Mutation_p.R53C|CYLD_ENST00000566206.1_Missense_Mutation_p.R53C|CYLD_ENST00000564326.1_Missense_Mutation_p.R53C			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	53					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				TATTCAAGATCGTTCTGTGGG	0.378000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				30	98					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106121904	106121904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106121904G>A	ENST00000369704.3	+	3	549	c.415G>A	c.(415-417)Gga>Aga	p.G139R	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	139										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GCAGGGGTCTGGACTGTCAAT	0.488000													15	26					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711559	20711559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20711559C>T	ENST00000315409.2	+	1	662	c.609C>T	c.(607-609)ccC>ccT	p.P203P		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CCCCAGCTCCCATAACTGAAT	0.423000													80	185					0	0	1	0	0
UBASH3A	53347	broad.mit.edu	37	21	43833575	43833575	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43833575C>T	ENST00000319294.6	+	5	641	c.610C>T	c.(610-612)Ctg>Ttg	p.L204L	UBASH3A_ENST00000291535.6_Intron|UBASH3A_ENST00000398367.1_Intron	NM_018961.3	NP_061834.1	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing A	204						cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						TGGCCCTAACCTGAGGCTGAG	0.527000													16	42					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17918740	17918740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17918740G>A	ENST00000318683.6	+	2	271	c.124G>A	c.(124-126)Gcg>Acg	p.A42T	B3GNT3_ENST00000595387.1_Missense_Mutation_p.A42T	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	42					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						GCAGCCACCGGCGATCCCCGA	0.677000													4	51					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88027354	88027354	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:88027354A>G	ENST00000227266.5	-	7	1326	c.1212T>C	c.(1210-1212)aaT>aaC	p.N404N		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	404					immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAACAGCATGATTAGTCAGCT	0.488000													16	57					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31341840	31341840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31341840C>T	ENST00000544665.3	+	28	3264	c.3193C>T	c.(3193-3195)Ctc>Ttc	p.L1065F	ITGAM_ENST00000287497.8_Missense_Mutation_p.L1064F	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1064					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GCATAACCACCTCCTGATCGT	0.617000													7	23					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2057320	2057320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2057320G>A	ENST00000262113.4	+	25	3319	c.3178G>A	c.(3178-3180)Gag>Aag	p.E1060K	MYOM2_ENST00000523438.1_Missense_Mutation_p.E485K	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1060					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTCTGACAGCGAGGTGAGTTC	0.473000													16	42					0	0	1	0	0
PTENP1	11191	broad.mit.edu	37	9	33676025	33676025	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33676025C>T	ENST00000532280.1	-	0	1472					NR_023917.1																						TTGCAAGTTCCGCCACTGAAC	0.418000													38	118					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187672	140187672	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140187672A>C	ENST00000530339.1	+	1	900	c.900A>C	c.(898-900)ggA>ggC	p.G300G	PCDHA4_ENST00000512229.2_Silent_p.G300G|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.G300G|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATTACTGGACAAATTATTG	0.353000													29	128					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774735	122774735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:122774735G>A	ENST00000227349.2	+	3	744	c.447G>A	c.(445-447)gaG>gaA	p.E149E	C11orf63_ENST00000307257.6_Silent_p.E149E|C11orf63_ENST00000531316.1_Silent_p.E149E	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	149										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		CGTTGCCGGAGTCCACGGACA	0.522000													55	140					0	0	1	0	0
PANX2	56666	broad.mit.edu	37	22	50615655	50615655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50615655C>T	ENST00000395842.2	+	2	514	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C	PANX2_ENST00000159647.5_Missense_Mutation_p.R172C	NM_052839.3	NP_443071.2	Q96RD6	PANX2_HUMAN	pannexin 2	172					protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)	7		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		GGCCGAGGGCCGCGCGCCCAA	0.662000													7	17					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109686778	109686778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:109686778C>T	ENST00000277225.5	+	3	874	c.585C>T	c.(583-585)ccC>ccT	p.P195P	ZNF462_ENST00000457913.1_Silent_p.P195P			Q96JM2	ZN462_HUMAN	zinc finger protein 462	195					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CCACTGCTCCCCCACCTGCTC	0.512000													21	36					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164272587	164272587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164272587C>T	ENST00000515560.1	+	4	2684	c.1162C>T	c.(1162-1164)Cat>Tat	p.H388Y	NPY5R_ENST00000506953.1_Missense_Mutation_p.H388Y|NPY5R_ENST00000338566.3_Missense_Mutation_p.H388Y			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	388					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				ACACCTTTTCCATGTGGTAAC	0.343000													39	91					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10235458	10235458	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10235458G>A	ENST00000418404.3	-	19	2419	c.2256C>T	c.(2254-2256)tcC>tcT	p.S752S	MYH13_ENST00000570743.1_Silent_p.S752S|MYH13_ENST00000252172.4_Silent_p.S752S|RP11-401O9.3_ENST00000577743.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	752	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCACATCGATGGAGTTGAGGA	0.547000													29	38					0	0	1	0	0
PON2	5445	broad.mit.edu	37	7	95035513	95035513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:95035513G>A	ENST00000536183.1	-	8	1070	c.887C>T	c.(886-888)tCc>tTc	p.S296F	PON2_ENST00000222572.3_Missense_Mutation_p.S275F|PON2_ENST00000433091.2_Missense_Mutation_p.S263F|PON2_ENST00000483292.1_5'UTR	NM_000305.2	NP_000296.2	Q15165	PON2_HUMAN	paraoxonase 2	275					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			GTCCCCCGAGGAAGGATCAAT	0.403000													48	138					0	0	1	0	0
C15orf27	123591	broad.mit.edu	37	15	76426617	76426617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:76426617C>T	ENST00000388942.3	+	2	289	c.13C>T	c.(13-15)Cca>Tca	p.P5S		NM_152335.2	NP_689548.2	Q2M3C6	CO027_HUMAN	chromosome 15 open reading frame 27	5						integral to membrane				endometrium(1)|large_intestine(1)|lung(10)|pancreas(1)	13						GGCTGTGGCTCCATCTTTCAA	0.463000													62	64					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125025715	125025715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125025715G>A	ENST00000522917.1	+	15	2072	c.1866G>A	c.(1864-1866)caG>caA	p.Q622Q	FER1L6_ENST00000399018.1_Silent_p.Q622Q|FER1L6-AS1_ENST00000518567.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	622						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AGATTTCACAGGAGGCACCTG	0.483000													42	88					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179576907	179576907	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179576907G>A	ENST00000589042.1	-	96	27874	c.27650C>T	c.(27649-27651)tCt>tTt	p.S9217F	TTN_ENST00000342992.6_Missense_Mutation_p.S7973F|TTN_ENST00000591111.1_Missense_Mutation_p.S8900F|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8900	Ig-like 75.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCCAACAGACACCTTAAC	0.463000													24	54					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002441	98002441	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:98002441G>A	ENST00000355273.2	+	1	710	c.710G>A	c.(709-711)aGa>aAa	p.R237K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						AAGTCTGTTAGAGGCGTAAGG	0.393000													22	67					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5013342	5013342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5013342C>T	ENST00000380390.1	+	6	960	c.744C>T	c.(742-744)atC>atT	p.I248I	MMP26_ENST00000300762.1_Silent_p.I248I			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	248					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TCCAAAGGATCCAGCATTTGT	0.448000													24	46					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16060098	16060098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16060098C>T	ENST00000322107.1	+	1	281	c.281C>T	c.(280-282)aCc>aTc	p.T94I		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						CATTCCATCACCTTTGTGGCT	0.512000													95	303					0	0	1	0	0
HSPA4	3308	broad.mit.edu	37	5	132400719	132400719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132400719C>T	ENST00000304858.2	+	2	444	c.155C>T	c.(154-156)gCt>gTt	p.A52V		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	52					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAGCAGCAGCTAAAAGCCAG	0.348000													12	108					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82785996	82785996	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82785996T>C	ENST00000265077.3	+	3	715	c.150T>C	c.(148-150)ccT>ccC	p.P50P	VCAN_ENST00000512590.2_Silent_p.P2P|VCAN_ENST00000513984.1_Silent_p.P50P|VCAN_ENST00000502527.2_Silent_p.P50P|VCAN_ENST00000343200.5_Silent_p.P50P|VCAN_ENST00000342785.4_Silent_p.P50P	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	50	Ig-like V-type.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAACGATGCCTACTTTGCCAC	0.438000													55	93					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24886121	24886121	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24886121C>T	ENST00000382554.3	+	9	5484	c.5166C>T	c.(5164-5166)ttC>ttT	p.F1722F		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1722	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						ACTGGGAATTCAAGAGGGCCC	0.637000													6	16					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147481403	147481403	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147481403G>A	ENST00000359874.3	+	15	1435	c.1362G>A	c.(1360-1362)gaG>gaA	p.E454E	SPINK5_ENST00000256084.7_Silent_p.E454E|SPINK5_ENST00000398454.1_Silent_p.E454E	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	454	Kazal-like 7.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACCAGAGAGAATGACCCCA	0.493000													31	87					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75740713	75740713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75740713C>T	ENST00000370855.5	-	6	303	c.190G>A	c.(190-192)Gac>Aac	p.D64N	SLC44A5_ENST00000370859.3_Missense_Mutation_p.D64N|SLC44A5_ENST00000535611.1_Intron|SLC44A5_ENST00000469525.1_5'UTR	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	64						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						CTTCTGGGGTCCCCATGTACC	0.493000													5	27					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45556204	45556204	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:45556204G>A	ENST00000588982.1	-	4	1788	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	ZBTB7C_ENST00000586438.1_Silent_p.F429F|ZBTB7C_ENST00000535628.2_Silent_p.F429F|ZBTB7C_ENST00000590800.1_Silent_p.F429F|ZBTB7C_ENST00000332053.2_Silent_p.F429F			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	429						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						AGTTGTGCACGAACTTGGCGT	0.592000													6	51					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256436	69256436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:69256436G>A	ENST00000439696.2	-	2	1132	c.831C>T	c.(829-831)ttC>ttT	p.F277F	ZFP36L1_ENST00000336440.3_Silent_p.F277F|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	277					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCCGGAAGAGGAAGGTGGTCG	0.632000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	95					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1558805	1558805	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:1558805G>A	ENST00000572621.1	-	36	6091	c.5826C>T	c.(5824-5826)gcC>gcT	p.A1942A	PRPF8_ENST00000304992.6_Silent_p.A1942A			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1942	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCACATGTAGGGCACGCAGAA	0.498000													41	57					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73832317	73832317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73832317G>A	ENST00000207549.4	-	16	1789	c.1410C>T	c.(1408-1410)ttC>ttT	p.F470F	UNC13D_ENST00000412096.2_Silent_p.F470F	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	470	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTTCAGGTGGAACCATTCAG	0.667000									Familial Hemophagocytic Lymphohistiocytosis				7	11					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43778170	43778170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43778170G>A	ENST00000372476.3	+	12	1904	c.1825G>A	c.(1825-1827)Gga>Aga	p.G609R	TIE1_ENST00000433781.2_Missense_Mutation_p.G254R	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	609	Fibronectin type-III 2.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTCCTGACGGGACTCACGCC	0.711000													13	44					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121016536	121016536	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121016536G>A	ENST00000392793.1	+	12	4087	c.3816G>A	c.(3814-3816)aaG>aaA	p.K1272K	TECTA_ENST00000264037.2_Silent_p.K1272K|TECTA_ENST00000478058.1_3'UTR			O75443	TECTA_HUMAN	tectorin alpha	1272	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCTGGGTGAAGAGGGACACCT	0.592000													25	103					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552399	1552399	+	Missense_Mutation	SNP	G	G	A	rs142083473	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1552399G>A	ENST00000381605.4	-	3	782	c.718C>T	c.(718-720)Cgt>Tgt	p.R240C	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000262929.5_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	240	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.R240C(1)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						GCAGTCCCACGAAGAGGGTCC	0.627000													31	76					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78380676	78380676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78380676C>T	ENST00000278550.7	-	32	7176	c.6714G>A	c.(6712-6714)cgG>cgA	p.R2238R		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GGATGTCATACCGTAGTGGTG	0.557000													62	109					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84488747	84488747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:84488747G>A	ENST00000286744.5	+	6	772	c.548G>A	c.(547-549)gGa>gAa	p.G183E	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G183E	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	183						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GTACTGGATGGAACTCGTTGC	0.532000													18	69					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121659731	121659731	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:121659731C>T	ENST00000489711.1	+	22	2455	c.2067C>T	c.(2065-2067)ttC>ttT	p.F689F	SLC15A2_ENST00000295605.2_Silent_p.F658F	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	689					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GCCTGATCTTCTCCATCATGG	0.458000													34	77					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32933287	32933287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:32933287G>A	ENST00000383763.4	+	4	2654	c.2591G>A	c.(2590-2592)cGa>cAa	p.R864Q		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	864					multicellular organismal development	cytoplasm	zinc ion binding	p.R864Q(1)		breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GGCAACAATCGAATCCTCGTC	0.512000													17	161					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753646	76753646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76753646C>T	ENST00000536229.3	+	1	1965	c.1256C>T	c.(1255-1257)tCc>tTc	p.S419F	SALL3_ENST00000575389.2_Missense_Mutation_p.S552F|SALL3_ENST00000537592.2_Missense_Mutation_p.S552F			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	552					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCCAGCCGCTCCCCGCAGAGG	0.746000													4	18					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17053361	17053361	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:17053361C>T	ENST00000418129.2	+	2	2610	c.2145C>T	c.(2143-2145)ttC>ttT	p.F715F	PLCL2_ENST00000396755.2_Silent_p.F715F|PLCL2_ENST00000432376.1_Silent_p.F715F	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	841	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GGGATGAATTCATCGGCCAGT	0.468000													41	102					0	0	1	0	0
UGT1A8	54576	broad.mit.edu	37	2	234527192	234527192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234527192G>A	ENST00000373450.4	+	1	902	c.839G>A	c.(838-840)gGa>gAa	p.G280E		NM_019076.4	NP_061949.3														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGCCATCAGGGAAAGCCATTG	0.398000													107	312					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961116	1961116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1961116G>A	ENST00000217305.2	-	4	843	c.618C>T	c.(616-618)cgC>cgT	p.R206R	RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Silent_p.R206R|PDYN_ENST00000539905.1_Silent_p.R206R	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	206					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGCCCCCATAGCGTTTGTACA	0.592000													53	138					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544344	82544344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82544344C>T	ENST00000423517.2	-	7	13295	c.12958G>A	c.(12958-12960)Gag>Aag	p.E4320K	PCLO_ENST00000437081.1_Missense_Mutation_p.E1040K|PCLO_ENST00000333891.8_Missense_Mutation_p.E4320K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4251					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCTTCAGCCTCTTGAGCTTTC	0.443000													14	28					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51172764	51172764	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51172764G>A	ENST00000440970.1	-	2	3509	c.3078C>T	c.(3076-3078)ctC>ctT	p.L1026L	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.L1123L	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1123					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GCAGAGCAGGGAGCAGAACTG	0.567000													13	51					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128498132	128498132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128498132C>T	ENST00000325888.8	+	47	8112	c.7851C>T	c.(7849-7851)tcC>tcT	p.S2617S	FLNC_ENST00000346177.6_Silent_p.S2584S|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2617	Hinge 2.|Interaction with INPPL1.|Self-association site, tail (By similarity).				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TGACCAAGTCCTCCTCAAGCC	0.637000													7	23					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122420051	122420051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122420051C>T	ENST00000474629.2	+	6	2916	c.2650C>T	c.(2650-2652)Cgc>Tgc	p.R884C		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	884	Macro 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		AGTGGGGCCCCGCTGGAGCGG	0.557000													9	23					0	0	1	0	0
TMEM184A	202915	broad.mit.edu	37	7	1587388	1587388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:1587388C>T	ENST00000297477.5	-	8	1318	c.1002G>A	c.(1000-1002)gaG>gaA	p.E334E		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	334						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		CTGGTGAATTCTCCTTCTTCT	0.637000													6	22					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65264525	65264525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65264525G>A	ENST00000389722.3	-	9	1157	c.1104C>T	c.(1102-1104)acC>acT	p.T368T	SPTB_ENST00000556626.1_Silent_p.T368T|SPTB_ENST00000542895.1_Silent_p.T368T|SPTB_ENST00000389721.5_Silent_p.T368T|SPTB_ENST00000389720.3_Silent_p.T368T	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	368					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GGGACTGGATGGTAAAAAGTA	0.428000													14	129					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78944602	78944602	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:78944602G>A	ENST00000286627.5	-	4	1627	c.675C>T	c.(673-675)ttC>ttT	p.F225F	KCNMA1_ENST00000372440.1_Silent_p.F225F|KCNMA1_ENST00000354353.5_Silent_p.F225F|KCNMA1_ENST00000404857.1_Silent_p.F225F|KCNMA1_ENST00000406533.3_Silent_p.F225F|KCNMA1_ENST00000286628.8_Silent_p.F225F|KCNMA1_ENST00000404771.3_Silent_p.F225F|KCNMA1_ENST00000372443.1_Silent_p.F225F	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	225					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	AGTAGAGAAGGAAGAACACGT	0.453000													33	99					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14479246	14479246	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:14479246G>A	ENST00000581457.1	-	0	662					NR_024076.1																						ACAGGAGCACGAAGCGCAGCA	0.612000													9	21					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53844098	53844098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53844098C>T	ENST00000288139.3	+	48	6143	c.6025C>T	c.(6025-6027)Ccc>Tcc	p.P2009S	CACNA1D_ENST00000422281.2_Missense_Mutation_p.P1965S|CACNA1D_ENST00000544977.1_3'UTR|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P1989S	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1989					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	AGCAACCCCTCCCTACCGGGA	0.632000													15	85					0	0	1	0	0
TRAV38-2DV8	28643	broad.mit.edu	37	14	22749075	22749075	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22749075C>T	ENST00000390465.2	+	0	88																											TGATCTCCACCTGTCTTGGTA	0.468000													45	96					0	0	1	0	0
MRPL1	65008	broad.mit.edu	37	4	78804493	78804493	+	Missense_Mutation	SNP	G	G	A	rs116727867	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:78804493G>A	ENST00000315567.8	+	3	570	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K	MRPL1_ENST00000506674.1_3'UTR	NM_020236.3	NP_064621.3	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1	81							RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)	17						TATGGAAGGCGAACCTGAGGA	0.333000													27	72					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43376039	43376039	+	Missense_Mutation	SNP	C	C	T	rs1058692		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43376039C>T	ENST00000244296.2	-	3	726	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	PSG1_ENST00000312439.6_Missense_Mutation_p.E197K|PSG1_ENST00000436291.2_Missense_Mutation_p.E197K|PSG1_ENST00000403380.3_Intron|PSG1_ENST00000595124.1_Intron|PSG1_ENST00000595356.1_Missense_Mutation_p.E197K	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				CTGTTGGTTTCGGACAGCTTC	0.527000													34	579					0	0	1	0	0
IL1R2	7850	broad.mit.edu	37	2	102626047	102626047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102626047C>T	ENST00000332549.3	+	3	320	c.91C>T	c.(91-93)Cgt>Tgt	p.R31C	IL1R2_ENST00000441002.1_Missense_Mutation_p.R31C|IL1R2_ENST00000393414.2_Missense_Mutation_p.R31C	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	31	Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	CTGCCGGTTTCGTGGGAGGCA	0.612000													53	143					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15364970	15364970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15364970G>A	ENST00000263377.2	-	11	2372	c.2151C>T	c.(2149-2151)tcC>tcT	p.S717S	BRD4_ENST00000360016.5_Silent_p.S717S|BRD4_ENST00000371835.4_Silent_p.S717S	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	717	Ser-rich.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			AACCTGTTTCGGAGTCTTCGC	0.542000			T	C15orf55	lethal midline carcinoma of young people								7	43					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51382209	51382209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51382209C>T	ENST00000216392.7	-	11	1580	c.1248G>A	c.(1246-1248)gtG>gtA	p.V416V	PYGL_ENST00000532462.1_Silent_p.V416V|PYGL_ENST00000544180.2_Silent_p.V382V	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	416					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	GAAACAAGGCCACAATTCTCT	0.448000													25	68					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52174539	52174539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52174539G>A	ENST00000354534.5	+	21	4104	c.3926G>A	c.(3925-3927)cGa>cAa	p.R1309Q	SCN8A_ENST00000545061.1_Intron	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1309					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GCCTTATCACGATTTGAAGGG	0.458000													10	26					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181740436	181740436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181740436G>A	ENST00000526775.1	+	35	4997	c.4832G>A	c.(4831-4833)gGa>gAa	p.G1611E	CACNA1E_ENST00000367570.1_Missense_Mutation_p.G1630E|CACNA1E_ENST00000367567.4_Missense_Mutation_p.G1237E|CACNA1E_ENST00000360108.3_Missense_Mutation_p.G1611E|CACNA1E_ENST00000357570.5_Missense_Mutation_p.G1581E|CACNA1E_ENST00000358338.5_Missense_Mutation_p.G1562E|CACNA1E_ENST00000367573.2_Missense_Mutation_p.G1630E	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1630					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AAGGTATTTGGAAACATAAAA	0.463000													5	3					0	0	1	0	0
CLRN3	119467	broad.mit.edu	37	10	129682033	129682033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129682033G>A	ENST00000368671.3	-	2	498	c.336C>T	c.(334-336)ttC>ttT	p.F112F		NM_152311.3	NP_689524.1	Q8NCR9	CLRN3_HUMAN	clarin 3	112						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				TGCTGTTGTAGAAGGTAAACC	0.532000													44	90					0	0	1	0	0
TRAV6	6956	broad.mit.edu	37	14	22237033	22237033	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22237033G>A	ENST00000390428.3	+	0	117																											TTCTGCCTAGGGGTGAAGAGC	0.473000													6	16					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699483	52699483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52699483G>A	ENST00000293525.5	+	6	989	c.937G>A	c.(937-939)Gag>Aag	p.E313K	KRT86_ENST00000544024.1_Missense_Mutation_p.E313K|KRT86_ENST00000423955.2_Missense_Mutation_p.E313K	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	313	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		CAGGCACGGGGAGACCCTGCG	0.597000													7	81					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45404008	45404008	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45404008C>T	ENST00000389039.6	-	5	856	c.471G>A	c.(469-471)tgG>tgA	p.W157*	DUOX2_ENST00000603300.1_Nonsense_Mutation_p.W157*			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	157	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TCTCGGGGTCCCAGCGGCTCC	0.726000													5	13					0	0	1	0	0
LELP1	149018	broad.mit.edu	37	1	153177391	153177391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153177391C>T	ENST00000368747.1	+	2	318	c.208C>T	c.(208-210)Cct>Tct	p.P70S		NM_001010857.1	NP_001010857.1	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	70	Cys/Pro-rich.									NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|pancreas(1)|prostate(1)	19	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCATCCTGCCCTCCCCAGCC	0.612000													24	44					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162497	90162497	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:90162497C>T	ENST00000567960.1	+	0	1233				TUBB8P7_ENST00000564451.1_RNA																							TTCACCGAGGCCGAGAGCAAC	0.542000													45	102					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55924936	55924936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55924936G>A	ENST00000244728.5	-	28	2885	c.2488C>T	c.(2488-2490)Cct>Tct	p.P830S	COL21A1_ENST00000535941.1_Missense_Mutation_p.P830S|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Intron|COL21A1_ENST00000370819.1_Missense_Mutation_p.P827S	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	830	Collagen-like 6.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GGTGGCCCAGGAATACCCGGG	0.522000													14	36					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32891041	32891041	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32891041C>T	ENST00000330048.5	-	0	2925					NR_003083.2																						TACATCCCACCCTGGGGGACA	0.597000													22	70					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28441679	28441679	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28441679A>T	ENST00000261609.7	-	51	8156	c.8048T>A	c.(8047-8049)tTt>tAt	p.F2683Y		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2683					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTGCTGGGGAAAGTCGACAAT	0.413000													13	83					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10538689	10538689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10538689C>T	ENST00000583535.1	-	30	4254	c.4167G>A	c.(4165-4167)gaG>gaA	p.E1389E	MYH3_ENST00000226209.7_Silent_p.E1389E	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1389					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CGCACTTGGCCTCCTCCAGCT	0.488000													59	74					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25585831	25585831	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:25585831G>T	ENST00000269141.3	-	6	1252	c.829C>A	c.(829-831)Cct>Act	p.P277T	CDH2_ENST00000399380.3_Missense_Mutation_p.P246T	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	277	Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GATCCCTCAGGAACTGTCCCA	0.398000													33	98					1.22384e-17	1.23084e-17	1	1	0
PCDHB3	56132	broad.mit.edu	37	5	140480800	140480800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140480800G>A	ENST00000231130.2	+	1	567	c.567G>A	c.(565-567)agG>agA	p.R189R	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		189	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGACGGAAGGAAGTACCCGG	0.567000													23	82					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	19955098	19955098	+	Silent	SNP	C	C	T	rs113762718		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:19955098C>T	ENST00000396085.1	+	7	1669	c.1308C>T	c.(1306-1308)ttC>ttT	p.F436F	NAV2_ENST00000360655.4_Silent_p.F372F|NAV2_ENST00000527559.2_Silent_p.F388F|NAV2_ENST00000349880.4_Silent_p.F436F|NAV2_ENST00000540292.1_Silent_p.F390F|NAV2_ENST00000396087.3_Silent_p.F459F	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	459						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						TGCCCAGCTTCGAAGAGAGCG	0.612000													33	75					0	0	1	0	0
CHCHD5	84269	broad.mit.edu	37	2	113343825	113343825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113343825C>T	ENST00000409719.1	+	3	245	c.192C>T	c.(190-192)gcC>gcT	p.A64A	CHCHD5_ENST00000489052.1_3'UTR|CHCHD5_ENST00000324913.5_Silent_p.A64A			Q9BSY4	CHCH5_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 5	64	CHCH.									NS(1)|endometrium(1)|large_intestine(4)|urinary_tract(1)	7						CTTTTGAGGCCTTCGAGGAGT	0.637000													19	54					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6309800	6309800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6309800G>A	ENST00000301452.4	-	4	473	c.396C>T	c.(394-396)acC>acT	p.T132T		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	132						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						AGGACAGAAGGGTGCTGACCA	0.597000													13	59					0	0	1	0	0
CALU	813	broad.mit.edu	37	7	128399014	128399014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128399014C>T	ENST00000542996.2	+	5	1472	c.529C>T	c.(529-531)Ctc>Ttc	p.L177F	CALU_ENST00000449187.2_Missense_Mutation_p.L169F|CALU_ENST00000535011.2_Missense_Mutation_p.L169F|CALU_ENST00000535623.1_3'UTR|CALU_ENST00000538546.1_Missense_Mutation_p.L18F|CALU_ENST00000479257.1_Missense_Mutation_p.L177F|CALU_ENST00000249364.4_Missense_Mutation_p.L169F	NM_001199672.1	NP_001186601.1	O43852	CALU_HUMAN	calumenin	169	EF-hand 3.				platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding			kidney(2)|large_intestine(3)|lung(5)	10						GGATGGAGACCTCATTGCCAC	0.428000													84	215					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126315103	126315103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126315103G>A	ENST00000335110.5	+	1	13	c.13G>A	c.(13-15)Gta>Ata	p.V5I	FAT4_ENST00000394329.3_Intron			Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1179					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGTAACAACGGTAGTGGCAGT	0.388000													15	44					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72998408	72998408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:72998408C>T	ENST00000322038.5	+	2	1495	c.911C>T	c.(910-912)cCc>cTc	p.P304L	TSHZ1_ENST00000580243.1_Missense_Mutation_p.P349L	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	349						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		AAACTGGTCCCCTCCACCAAA	0.592000													23	67					0	0	1	0	0
OR2AT4	341152	broad.mit.edu	37	11	74800531	74800531	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74800531G>A	ENST00000305159.3	-	1	268	c.228C>T	c.(226-228)atC>atT	p.I76I		NM_001005285.1	NP_001005285.1	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT, member 4	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	12						TGGTGAAAAGGATGTCCAAGG	0.527000													16	43					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51758499	51758499	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51758499G>A	ENST00000251076.5	-	30	7686	c.7399C>T	c.(7399-7401)Cct>Tct	p.P2467S	DMXL2_ENST00000543779.2_Missense_Mutation_p.P2468S|RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000449909.3_Missense_Mutation_p.P1831S	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2467						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TCAGACAAAGGAAGAAATGGC	0.244000													29	82					0	0	1	0	0
TARSL2	123283	broad.mit.edu	37	15	102241367	102241367	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:102241367G>A	ENST00000335968.3	-	10	1458	c.1242C>T	c.(1240-1242)ttC>ttT	p.F414F		NM_152334.2	NP_689547.2	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	414					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|skin(1)|urinary_tract(1)	29	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCAAATCGTGGAAAAAGAAAA	0.323000													46	51					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137717743	137717743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:137717743C>T	ENST00000343735.4	+	1	167	c.33C>T	c.(31-33)ttC>ttT	p.F11F		NM_001002026.2	NP_001002026.1	P56856	CLD18_HUMAN	claudin 18	11					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						GCTTGGGGTTCGTGGTTTCAC	0.557000													28	78					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60908263	60908263	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60908263G>A	ENST00000252999.3	-	26	3231	c.3165C>T	c.(3163-3165)ttC>ttT	p.F1055F		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1055	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGCCGAGGGGAAGCCATCCA	0.711000													12	31					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23526574	23526574	+	Silent	SNP	G	G	A	rs112001060		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:23526574G>A	ENST00000296682.3	+	11	1559	c.1377G>A	c.(1375-1377)agG>agA	p.R459R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	459					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.R459S(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TCAAAGAAAGGTCCAAACTCT	0.468000										HNSCC(3;0.000094)			10	28					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26157080	26157080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26157080C>T	ENST00000335473.7	+	2	271	c.21C>T	c.(19-21)ctC>ctT	p.L7L	MYO18B_ENST00000536101.1_Silent_p.L7L|MYO18B_ENST00000407587.2_Silent_p.L7L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	7						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CATCACGCCTCGCCCTGTGGG	0.592000													25	99					0	0	1	0	0
ARIH2	10425	broad.mit.edu	37	3	49012254	49012254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49012254C>T	ENST00000356401.4	+	10	1232	c.893C>T	c.(892-894)cCc>cTc	p.P298L	ARIH2_ENST00000449376.1_Missense_Mutation_p.P298L|ARIH2_ENST00000490095.1_3'UTR	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	298					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		CCTCAGTGTCCCAAGTGCAAC	0.498000													28	77					0	0	1	0	0
IL32	9235	broad.mit.edu	37	16	3119355	3119355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3119355G>A	ENST00000525643.2	+	7	898	c.566G>A	c.(565-567)tGa>tAa	p.*189*	IL32_ENST00000551513.1_Silent_p.*226*|IL32_ENST00000528163.2_Silent_p.*189*|IL32_ENST00000552936.1_Silent_p.*213*|IL32_ENST00000552356.1_Silent_p.*169*|IL32_ENST00000526464.2_Silent_p.*189*|IL32_ENST00000549213.1_Silent_p.*132*|IL32_ENST00000529550.1_Silent_p.*189*|IL32_ENST00000530538.2_Silent_p.*189*|IL32_ENST00000531965.1_Silent_p.*179*|IL32_ENST00000396887.3_Silent_p.*132*|IL32_ENST00000008180.9_Silent_p.*169*|IL32_ENST00000440815.3_Silent_p.*189*|IL32_ENST00000325568.5_Silent_p.*189*|IL32_ENST00000548652.1_Silent_p.*180*|IL32_ENST00000548246.1_Silent_p.*149*|IL32_ENST00000533097.2_Silent_p.*189*|IL32_ENST00000534507.1_Silent_p.*235*|IL32_ENST00000548476.1_Silent_p.*235*|IL32_ENST00000552664.1_Silent_p.*189*|IL32_ENST00000396890.2_Silent_p.*235*|IL32_ENST00000444393.3_Silent_p.*189*|IL32_ENST00000382213.3_Silent_p.*180*|IL32_ENST00000530890.1_Silent_p.*169*|IL32_ENST00000551122.1_Silent_p.*132*|IL32_ENST00000529699.1_Silent_p.*169*			P24001	IL32_HUMAN	interleukin 32	0					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						TCCTCAAAATGAAGATACTGA	0.617000													20	186					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26294333	26294333	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26294333G>A	ENST00000335473.7	+	29	4978	c.4728G>A	c.(4726-4728)agG>agA	p.R1576R	CTA-125H2.2_ENST00000594856.1_RNA|CTA-125H2.2_ENST00000599080.1_RNA|CTA-125H2.2_ENST00000453457.2_RNA|CTA-125H2.2_ENST00000600903.1_RNA|MYO18B_ENST00000536101.1_Silent_p.R1576R|CTA-125H2.2_ENST00000600269.1_RNA|CTA-125H2.2_ENST00000594542.1_RNA|CTA-125H2.2_ENST00000599792.1_RNA|CTA-125H2.2_ENST00000594585.1_RNA|CTA-125H2.2_ENST00000597284.1_RNA|MYO18B_ENST00000407587.2_Silent_p.R1577R|CTA-125H2.2_ENST00000597548.1_RNA|CTA-125H2.2_ENST00000595102.1_RNA|CTA-125H2.2_ENST00000600211.1_RNA	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1576	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AACTGAAGAGGAAGTGCCACC	0.493000													28	72					0	0	1	0	0
TMEM196	256130	broad.mit.edu	37	7	19765192	19765192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:19765192C>T	ENST00000405844.1	-	3	1099	c.404G>A	c.(403-405)aGg>aAg	p.R135K	TMEM196_ENST00000433641.1_Missense_Mutation_p.R67K|TMEM196_ENST00000493519.1_Missense_Mutation_p.R67K|TMEM196_ENST00000422233.1_Missense_Mutation_p.R67K|TMEM196_ENST00000405764.3_Missense_Mutation_p.R135K			Q5HYL7	TM196_HUMAN	transmembrane protein 196	141						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						TGAGAACATCCTCCTCTGTTC	0.507000													22	42					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149477866	149477866	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149477866G>A	ENST00000378016.2	+	0	1637							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGTGCCCACAGCGTGTGCAGG	0.657000													5	10					0	0	1	0	0
ADAT3	113179	broad.mit.edu	37	19	1912832	1912832	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1912832C>T	ENST00000329478.2	+	2	1006	c.786C>T	c.(784-786)ttC>ttT	p.F262F	SCAMP4_ENST00000409472.1_Intron|SCAMP4_ENST00000414057.2_Intron|SCAMP4_ENST00000316097.8_Intron|ADAT3_ENST00000602400.1_Silent_p.F246F			Q96EY9	ADAT3_HUMAN	adenosine deaminase, tRNA-specific 3	246					tRNA processing		hydrolase activity|zinc ion binding	p.F246F(1)		breast(1)|kidney(3)|pancreas(1)|skin(2)	7		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGACCCTTCCCCGCCTGCT	0.726000													5	15					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21120489	21120489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21120489C>T	ENST00000377122.4	-	15	1869	c.1473G>A	c.(1471-1473)gaG>gaA	p.E491E	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	491					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TAATTTCAGTCTCCAGATCTC	0.428000													25	52					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117849481	117849481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117849481C>T	ENST00000350763.4	-	3	940	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K	TNC_ENST00000535648.1_Missense_Mutation_p.E177K|TNC_ENST00000542877.1_Missense_Mutation_p.E177K|TNC_ENST00000423613.2_Missense_Mutation_p.E177K|TNC_ENST00000346706.3_Missense_Mutation_p.E177K|TNC_ENST00000537320.1_Missense_Mutation_p.E177K|TNC_ENST00000341037.4_Missense_Mutation_p.E177K|TNC_ENST00000345230.3_Missense_Mutation_p.E177K|TNC_ENST00000340094.3_Missense_Mutation_p.E177K	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	177	EGF-like 1; incomplete.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						CAGCCAGGTTCGCAGACACAG	0.582000													26	79					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171686121	171686121	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:171686121C>T	ENST00000358196.3	+	4	832	c.282C>T	c.(280-282)gaC>gaT	p.D94D	GAD1_ENST00000429023.1_3'UTR|GAD1_ENST00000344257.5_Silent_p.D94D|GAD1_ENST00000375272.1_Silent_p.D94D	NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	94					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CAGAGACTGACTTCTCTAATC	0.517000													33	103					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99640962	99640962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:99640962G>A	ENST00000345514.2	-	3	2264	c.1998C>T	c.(1996-1998)ttC>ttT	p.F666F	BCL11B_ENST00000357195.3_Silent_p.F737F|BCL11B_ENST00000443726.2_Silent_p.F543F	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	737						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		ACGACGTGGCGAAGGGCGACT	0.706000			T	TLX3	T-ALL								9	11					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9512533	9512533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9512533C>T	ENST00000402466.1	+	20	3589	c.2821C>T	c.(2821-2823)Cgt>Tgt	p.R941C	SETD5_ENST00000406341.1_Missense_Mutation_p.R1039C|SETD5_ENST00000402198.1_Missense_Mutation_p.R1039C|SETD5_ENST00000407969.1_Missense_Mutation_p.R1058C|SETD5_ENST00000302463.6_Missense_Mutation_p.R941C			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1039										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGACCTCTCTCGTGGATCCTT	0.478000													8	11					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166234156	166234156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166234156G>A	ENST00000357398.3	+	23	4594	c.4304G>A	c.(4303-4305)cGa>cAa	p.R1435Q	SCN2A_ENST00000375437.2_Missense_Mutation_p.R1435Q|SCN2A_ENST00000375427.2_Missense_Mutation_p.R1435Q|SCN2A_ENST00000283256.6_Missense_Mutation_p.R1435Q			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1435					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTTGATTCACGAAATGTAAGT	0.269000													34	94					0	0	1	0	0
FRMD4B	23150	broad.mit.edu	37	3	69230763	69230763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:69230763G>A	ENST00000542259.1	-	22	2427	c.1976C>T	c.(1975-1977)tCc>tTc	p.S659F	FRMD4B_ENST00000398540.3_Missense_Mutation_p.S713F|FRMD4B_ENST00000478263.1_Missense_Mutation_p.S365F			Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	713						cytoplasm|cytoskeleton	binding			NS(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(2)	19		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TTTGGAGAGGGAGAAAAATGG	0.517000													22	65					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	769422	769422	+	Missense_Mutation	SNP	G	G	A	rs142141660		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:769422G>A	ENST00000297440.6	+	2	738	c.718G>A	c.(718-720)Ggg>Agg	p.G240R	HEATR2_ENST00000438961.1_3'UTR|HEATR2_ENST00000313147.5_Missense_Mutation_p.G240R	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	240							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		TTTTGGCAACGGGAAGTCCGT	0.572000													18	41					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101375429	101375429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101375429G>A	ENST00000344327.3	-	2	695	c.271C>T	c.(271-273)Cgc>Tgc	p.R91C	TRPC6_ENST00000348423.4_Missense_Mutation_p.R91C|TRPC6_ENST00000360497.4_Missense_Mutation_p.R91C|TRPC6_ENST00000532133.1_Missense_Mutation_p.R91C	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	91					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CTTGTGGAGCGATCACTAAAC	0.507000													49	127					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24390596	24390596	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24390596C>T	ENST00000330966.7	-	30	3759	c.3597G>A	c.(3595-3597)ggG>ggA	p.G1199G	MYOM3_ENST00000338909.5_Silent_p.G89G|MYOM3_ENST00000374434.3_Silent_p.G1196G|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1196	Ig-like C2-type 3.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TGTCGTCCTCCCCTCGATCGT	0.552000													34	99					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73957010	73957010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73957010G>A	ENST00000358602.4	-	29	6451	c.6335C>T	c.(6334-6336)cCg>cTg	p.P2112L	ANKRD17_ENST00000330838.6_Missense_Mutation_p.P1861L|ANKRD17_ENST00000509867.2_Missense_Mutation_p.P1999L	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	2112					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AACAGATCCCGGAGGTTGTTG	0.483000													60	112					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125103744	125103744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125103744G>A	ENST00000522917.1	+	34	4678	c.4472G>A	c.(4471-4473)gGa>gAa	p.G1491E	FER1L6_ENST00000399018.1_Missense_Mutation_p.G1491E|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1491						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAGCTGGATGGACCCTACTTT	0.453000													46	80					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46310067	46310067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:46310067C>T	ENST00000397850.2	-	13	1935	c.1483G>A	c.(1483-1485)Gga>Aga	p.G495R	ITGB2_ENST00000397854.3_Missense_Mutation_p.G438R|ITGB2_ENST00000397857.1_Missense_Mutation_p.G495R|ITGB2_ENST00000302347.5_Missense_Mutation_p.G495R|ITGB2_ENST00000397852.1_Missense_Mutation_p.G495R|ITGB2_ENST00000355153.4_Missense_Mutation_p.G495R			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	495	Cysteine-rich tandem repeats.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	CGGCAGCTTCCTTCCAGCTCC	0.632000													12	25					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29222072	29222072	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29222072C>T	ENST00000379558.4	+	4	516	c.165C>T	c.(163-165)gcC>gcT	p.A55A	FAM179A_ENST00000403861.2_Silent_p.A55A	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	55			A -> T (in dbSNP:rs13009279).				binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGCCAAGAGCCCTGCTGAACA	0.622000													6	20					0	0	1	0	0
C17orf77	146723	broad.mit.edu	37	17	72588686	72588686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72588686G>A	ENST00000392620.1	+	3	863	c.501G>A	c.(499-501)ggG>ggA	p.G167G	C17orf77_ENST00000328023.2_Silent_p.G167G	NM_152460.2	NP_689673.2	Q96MU5	CQ077_HUMAN	chromosome 17 open reading frame 77	167						extracellular region		p.G167G(1)		breast(2)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11						GGAGCTGCGGGATCTACTGCC	0.597000													18	35					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52596062	52596062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52596062G>A	ENST00000395489.2	-	8	751	c.355C>T	c.(355-357)Ctc>Ttc	p.L119F	A1CF_ENST00000395495.1_Missense_Mutation_p.L126F|A1CF_ENST00000373993.1_Missense_Mutation_p.L126F|A1CF_ENST00000374001.1_Missense_Mutation_p.L126F|A1CF_ENST00000373995.3_Missense_Mutation_p.L134F|A1CF_ENST00000373997.3_Missense_Mutation_p.L126F|A1CF_ENST00000282641.2_Missense_Mutation_p.L126F	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	126	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ACCCCTAAGAGGCGCCCATTT	0.438000													27	53					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47630061	47630061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:47630061C>T	ENST00000546455.1	+	4	1946	c.1215C>T	c.(1213-1215)ccC>ccT	p.P405P	PCED1B_ENST00000432328.1_Silent_p.P405P					PC-esterase domain containing 1B																		GGTATCGTCCCCGTGGCCCCT	0.592000													21	41					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33588480	33588480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:33588480G>A	ENST00000404816.2	+	29	4647	c.4294G>A	c.(4294-4296)Gga>Aga	p.G1432R	LTBP1_ENST00000404525.1_Missense_Mutation_p.G1053R|LTBP1_ENST00000402934.1_Missense_Mutation_p.G1051R|LTBP1_ENST00000272273.5_Missense_Mutation_p.G330R|LTBP1_ENST00000390003.4_Missense_Mutation_p.G1107R|LTBP1_ENST00000418533.2_Missense_Mutation_p.G1064R|LTBP1_ENST00000407925.1_Missense_Mutation_p.G1106R|LTBP1_ENST00000354476.3_Missense_Mutation_p.G1433R			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1432	EGF-like 15; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCTACTTTTTGGACAAGAAAT	0.383000													22	77					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122667443	122667443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122667443G>A	ENST00000195173.4	-	3	541	c.238C>T	c.(238-240)Cac>Tac	p.H80Y	SEMA5B_ENST00000465147.1_5'UTR|SEMA5B_ENST00000451055.2_Missense_Mutation_p.H134Y|SEMA5B_ENST00000357599.3_Missense_Mutation_p.H80Y			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	80					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		CTGGAGAGGTGGGACACCAGC	0.627000													10	42					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123239513	123239513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123239513G>A	ENST00000358487.5	-	18	2596	c.2324C>T	c.(2323-2325)cCt>cTt	p.P775L	FGFR2_ENST00000478859.1_Missense_Mutation_p.P547L|FGFR2_ENST00000369059.1_Missense_Mutation_p.P661L|FGFR2_ENST00000357555.5_Intron|FGFR2_ENST00000369060.4_Missense_Mutation_p.P659L|FGFR2_ENST00000346997.2_Missense_Mutation_p.P773L|FGFR2_ENST00000356226.4_Missense_Mutation_p.P658L|FGFR2_ENST00000457416.2_Missense_Mutation_p.P776L|FGFR2_ENST00000369061.4_Missense_Mutation_p.P663L	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	775					angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CTGTTCGAGAGGTTGGCTGAG	0.453000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				59	136					0	0	1	0	0
IGKV3-7	28915	broad.mit.edu	37	2	89278196	89278196	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89278196G>A	ENST00000390247.2	-	0	235																											CTAACACTCTGACTGGCCCTG	0.547000													24	121					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52946055	52946055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52946055G>A	ENST00000295213.4	+	9	1699	c.1325G>A	c.(1324-1326)gGa>gAa	p.G442E	SPATA18_ENST00000419395.2_Missense_Mutation_p.G410E	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	442					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			ATTGCATATGGAGCAGATGGA	0.418000													53	160					0	0	1	0	0
SLC38A7	55238	broad.mit.edu	37	16	58713945	58713945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58713945G>A	ENST00000570101.1	-	2	969	c.86C>T	c.(85-87)cCc>cTc	p.P29L	SLC38A7_ENST00000566953.1_Intron|SLC38A7_ENST00000219320.4_Missense_Mutation_p.P29L|SLC38A7_ENST00000564100.1_Missense_Mutation_p.P29L|SLC38A7_ENST00000564010.1_Intron|SLC38A7_ENST00000564391.1_Missense_Mutation_p.P29L			Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	29					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	13						GTCCACACAGGGACTCTGCAG	0.622000													4	20					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131234714	131234714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:131234714G>A	ENST00000298542.4	-	2	263	c.88C>T	c.(88-90)Ctg>Ttg	p.L30L	RP1-305B16.2_ENST00000513703.1_RNA|FRMD7_ENST00000464296.1_Silent_p.L30L	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	30	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					CTGCAACTCAGGTTAAACAAT	0.373000													46	29					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207133	58207133	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58207133C>T	ENST00000377918.3	+	1	479	c.453C>T	c.(451-453)ttC>ttT	p.F151F		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	151	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCACCCGCTTCCCCCTCACCA	0.617000													10	28					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6166483	6166483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:6166483G>A	ENST00000262450.3	-	40	5928	c.5829C>T	c.(5827-5829)aaC>aaT	p.N1943N	CHD5_ENST00000378021.1_Intron	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1943					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGGGCATCTGGTTGTAGTTGA	0.672000													5	7					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161324243	161324243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:161324243G>A	ENST00000428797.2	+	11	1541	c.1186G>A	c.(1186-1188)Gaa>Aaa	p.E396K	GABRA1_ENST00000023897.6_Missense_Mutation_p.E396K|GABRA1_ENST00000437025.2_Missense_Mutation_p.E396K|GABRA1_ENST00000420560.1_Missense_Mutation_p.E396K|GABRA1_ENST00000444819.1_Missense_Mutation_p.E396K|GABRA1_ENST00000393943.4_Missense_Mutation_p.E396K	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	396					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TGCAACCATAGAACCTAAAGA	0.478000													25	136					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105990440	105990440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105990440G>A	ENST00000357060.3	-	2	342	c.227C>T	c.(226-228)cCc>cTc	p.P76L	WDR96_ENST00000428666.1_Missense_Mutation_p.P76L|WDR96_ENST00000278064.2_Missense_Mutation_p.P6L|WDR96_ENST00000369720.1_Missense_Mutation_p.P6L|WDR96_ENST00000369719.1_Missense_Mutation_p.P6L	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	76										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AACTTCACAGGGGATGTTAGT	0.393000													32	100					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558075	140558075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140558075C>T	ENST00000239444.2	+	1	705	c.460C>T	c.(460-462)Cct>Tct	p.P154S		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		154	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACTGCGTTTCCTCTGAAGAA	0.438000													45	191					0	0	1	0	0
DAW1	164781	broad.mit.edu	37	2	228786229	228786229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228786229G>A	ENST00000309931.2	+	12	1248	c.1165G>A	c.(1165-1167)Gaa>Aaa	p.E389K	DAW1_ENST00000373666.2_3'UTR|DAW1_ENST00000545118.1_Missense_Mutation_p.E374K	NM_178821.1	NP_849143.1			dynein assembly factor with WDR repeat domains 1																		GCACACTGATGAAATCTTTTC	0.438000													30	88					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537629	55537629	+	Missense_Mutation	SNP	G	G	A	rs141279458	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:55537629G>A	ENST00000220676.1	+	4	1335	c.1187G>A	c.(1186-1188)cGa>cAa	p.R396Q		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	396					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCTATGGAGCGAAGCAGTAAT	0.433000													15	45					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128388858	128388858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:128388858G>A	ENST00000368227.3	-	12	2329	c.1963C>T	c.(1963-1965)Cct>Tct	p.P655S	PTPRK_ENST00000368215.3_Missense_Mutation_p.P655S|RP11-103C16.2_ENST00000417390.1_RNA|PTPRK_ENST00000368207.3_Missense_Mutation_p.P655S|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368210.3_Missense_Mutation_p.P655S|PTPRK_ENST00000368213.5_Missense_Mutation_p.P655S|PTPRK_ENST00000368226.4_Missense_Mutation_p.P655S|PTPRK_ENST00000532331.1_Missense_Mutation_p.P655S			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	655	Fibronectin type-III 4.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TATGTGACAGGAACCTGGTAG	0.522000													25	51					0	0	1	0	0
SLC24A5	283652	broad.mit.edu	37	15	48431226	48431226	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48431226C>A	ENST00000341459.3	+	7	1005	c.932C>A	c.(931-933)tCc>tAc	p.S311Y	SLC24A5_ENST00000449382.2_Missense_Mutation_p.S251Y	NM_205850.2	NP_995322.1	Q71RS6	NCKX5_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	311					response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|skin(1)|upper_aerodigestive_tract(1)	27		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		TGGGTATTATCCCTTCCTATT	0.318000													29	71					2.4375e-19	2.45195e-19	1	1	0
MYOM3	127294	broad.mit.edu	37	1	24432531	24432531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24432531C>T	ENST00000330966.7	-	5	604	c.442G>A	c.(442-444)Gag>Aag	p.E148K	MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Missense_Mutation_p.E147K|MYOM3_ENST00000374434.3_Missense_Mutation_p.E147K			Q5VTT5	MYOM3_HUMAN	myomesin 3	147								p.E147K(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TAGCACAGCTCCCTCAGCTCC	0.642000													12	34					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84255861	84255861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:84255861G>A	ENST00000405413.2	-	2	211	c.75C>T	c.(73-75)tcC>tcT	p.S25S	HPSE_ENST00000311412.5_Silent_p.S25S|HPSE_ENST00000513463.1_Silent_p.S25S|HPSE_ENST00000512196.1_Silent_p.S25S	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	25					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	GGGCGCCAGGGGAGAGGGGAC	0.711000													5	3					0	0	1	0	0
STEAP3	55240	broad.mit.edu	37	2	120005392	120005392	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120005392G>A	ENST00000354888.5	+	4	1134	c.630G>A	c.(628-630)ccG>ccA	p.P210P	STEAP3_ENST00000393108.2_Silent_p.P210P|STEAP3_ENST00000425223.2_Silent_p.P210P|STEAP3_ENST00000393107.2_Silent_p.P210P|STEAP3_ENST00000393106.2_Silent_p.P210P|STEAP3_ENST00000450943.2_Silent_p.P210P|STEAP3_ENST00000409811.1_Silent_p.P210P|STEAP3_ENST00000393110.2_Silent_p.P220P|STEAP3-AS1_ENST00000454260.1_RNA	NM_182915.2	NP_878919.2	Q658P3	STEA3_HUMAN	STEAP family member 3, metalloreductase	210					apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding	p.P210P(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	17						GCCTCCTCCCGGCCTGGAAGG	0.657000													16	53					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8245339	8245339	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8245339C>T	ENST00000339754.5	+	5	529	c.451C>T	c.(451-453)Ctg>Ttg	p.L151L		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	151					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		TAAGTTGGATCTGGGCTTCAA	0.408000													16	34					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88769257	88769257	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88769257G>A	ENST00000444431.1	+	0	3857				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										AGGGGCAGACGAAACCCTCAA	0.527000													59	158					0	0	1	0	0
CKS2	1164	broad.mit.edu	37	9	91931305	91931305	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91931305T>C	ENST00000314355.6	+	3	300	c.205T>C	c.(205-207)Ttt>Ctt	p.F69L		NM_001827.1	NP_001818.1	P33552	CKS2_HUMAN	CDC28 protein kinase regulatory subunit 2	69					cell division|cell proliferation|phosphatidylinositol-mediated signaling|regulation of cyclin-dependent protein kinase activity|spindle organization		cyclin-dependent protein kinase regulator activity			kidney(1)|large_intestine(1)	2						TATTCTTCTCTTTAGACGACC	0.289000													3	17					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47559743	47559743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47559743C>T	ENST00000273859.3	+	12	2156	c.1887C>T	c.(1885-1887)ttC>ttT	p.F629F	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	629					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						AAAGTCTTTTCCAGAGATGGT	0.448000													14	51					0	0	1	0	0
MMP25	64386	broad.mit.edu	37	16	3108551	3108551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3108551G>A	ENST00000336577.4	+	9	1535	c.1298G>A	c.(1297-1299)gGc>gAc	p.G433D	RP11-473M20.7_ENST00000572222.1_RNA|RP11-473M20.7_ENST00000572427.1_RNA|RP11-473M20.7_ENST00000572574.1_RNA|RP11-473M20.7_ENST00000576250.1_RNA	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	433	Hemopexin-like 3.				inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						CTGGTCCGCGGCCGGCAGTAC	0.751000													5	10					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121976336	121976336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:121976336C>T	ENST00000265922.3	-	6	1244	c.783G>A	c.(781-783)caG>caA	p.Q261Q	DBC1_ENST00000373964.2_Silent_p.Q261Q	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		261					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						ACTGGCTGTTCTGGCACAGGT	0.537000													16	71					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127967522	127967522	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:127967522C>T	ENST00000368679.4	-	3	531	c.222G>A	c.(220-222)cgG>cgA	p.R74R	ADAM12_ENST00000368676.4_Silent_p.R74R	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	74					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CTTTGCTTTCCCGTTGTAGTC	0.343000													5	27					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814282	60814282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60814282C>T	ENST00000544856.2	-	7	1322	c.944G>A	c.(943-945)aGa>aAa	p.R315K	MARCH10_ENST00000583600.1_Missense_Mutation_p.R354K|RP11-156L14.1_ENST00000577270.1_RNA|RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.R316K|MARCH10_ENST00000311269.5_Missense_Mutation_p.R316K			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	316							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						AAATCTACTTCTTTTGTGATG	0.453000													114	311					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53347812	53347812	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:53347812T>C	ENST00000395631.2	-	6	1013	c.797A>G	c.(796-798)gAa>gGa	p.E266G	FERMT2_ENST00000343279.4_Missense_Mutation_p.E266G|FERMT2_ENST00000553373.1_Missense_Mutation_p.E266G|FERMT2_ENST00000399304.3_Missense_Mutation_p.E266G|FERMT2_ENST00000341590.3_Missense_Mutation_p.E266G			Q96AC1	FERM2_HUMAN	fermitin family member 2	266	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					GGCCTCATTTTCCTTCACATC	0.368000													18	62					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27672907	27672907	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27672907C>A	ENST00000260570.3	-	36	4111	c.4008G>T	c.(4006-4008)ctG>ctT	p.L1336L		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1336					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GTCCTACAGCCAGAACGACTT	0.473000													18	55					3.41278e-10	3.42617e-10	1	1	0
SIGLEC11	114132	broad.mit.edu	37	19	50455584	50455584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50455584G>A	ENST00000447370.2	-	9	1809	c.1719C>T	c.(1717-1719)ctC>ctT	p.L573L	CTC-326K19.6_ENST00000451973.1_Intron|SIGLEC11_ENST00000426971.2_Silent_p.L477L	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	573					cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		AACAGAAAGCGAGCAGGGCAG	0.637000													32	107					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126777540	126777540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:126777540C>T	ENST00000373615.4	+	3	1202	c.463C>T	c.(463-465)Cac>Tac	p.H155Y		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	155	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						CACGGGCGACCACTTCGGCAT	0.607000													57	97					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77817742	77817742	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77817742C>T	ENST00000334306.2	-	1	1260	c.1261G>A	c.(1261-1263)Gag>Aag	p.E421K		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	421																	TGCAGCCCCTCTTCAGAAGCC	0.607000													9	154					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248005100	248005100	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248005100G>A	ENST00000355784.2	-	1	154	c.99C>T	c.(97-99)ctC>ctT	p.L33L		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCAGTAGATGAGCAGGAAAA	0.498000													14	38					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143055978	143055978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143055978C>T	ENST00000409408.1	-	4	2032	c.324G>A	c.(322-324)agG>agA	p.R108R	FAM131B_ENST00000409578.1_Silent_p.R124R|FAM131B_ENST00000409222.3_Silent_p.R108R|FAM131B_ENST00000443739.2_Silent_p.R136R|FAM131B_ENST00000409346.1_Silent_p.R108R			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	108										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					CATCCGTATCCCTGCGCACGG	0.587000													12	38					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120824973	120824973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:120824973G>A	ENST00000369144.3	-	7	1187	c.1060C>T	c.(1060-1062)Cgc>Tgc	p.R354C	EIF3A_ENST00000541549.1_Missense_Mutation_p.R320C|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	354					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		GTTGCAAGGCGACGCTGTTTT	0.428000													30	99					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153546	5153546	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5153546G>A	ENST00000307388.1	-	1	326	c.327C>T	c.(325-327)ttC>ttT	p.F109F		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAATTGCCTGGAATGAGTGAA	0.453000													13	47					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204587068	204587068	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204587068G>T	ENST00000367175.1	-	1	4265	c.2053C>A	c.(2053-2055)Ccc>Acc	p.P685T	LRRN2_ENST00000367176.3_Missense_Mutation_p.P685T|LRRN2_ENST00000367177.3_Missense_Mutation_p.P685T			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	685					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			AGGACGAGGGGAGCAGACACA	0.617000													39	116					1.66425e-11	1.67124e-11	1	1	0
ESYT1	23344	broad.mit.edu	37	12	56531834	56531834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56531834C>T	ENST00000394048.5	+	20	2487	c.2223C>T	c.(2221-2223)gtC>gtT	p.V741V	ESYT1_ENST00000541590.1_Silent_p.V751V|ESYT1_ENST00000550878.1_3'UTR|ESYT1_ENST00000267113.4_Silent_p.V751V	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	741						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						TCACCACAGTCTTAAACAGTG	0.468000													22	124					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43626727	43626727	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:43626727T>A	ENST00000332857.6	-	4	1988	c.1960A>T	c.(1960-1962)Aag>Tag	p.K654*		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		AACTTCACCTTCTGTGCCTCC	0.567000													47	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640263	179640263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179640263C>T	ENST00000589042.1	-	28	6552	c.6328G>A	c.(6328-6330)Gaa>Aaa	p.E2110K	TTN_ENST00000342992.6_Missense_Mutation_p.E2110K|TTN_ENST00000360870.5_Missense_Mutation_p.E2110K|TTN_ENST00000591111.1_Missense_Mutation_p.E2110K|TTN_ENST00000342175.6_Missense_Mutation_p.E2064K|TTN_ENST00000359218.5_Missense_Mutation_p.E2064K|TTN_ENST00000460472.2_Missense_Mutation_p.E2064K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1873	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTACCATTCACATTCGGGG	0.483000													6	58					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160106098	160106098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160106098G>A	ENST00000361216.3	+	18	2590	c.2501G>A	c.(2500-2502)cGa>cAa	p.R834Q	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Missense_Mutation_p.R834Q	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	834					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CGGCAGCCACGAAACTCCCAG	0.597000													37	70					0	0	1	0	0
ARMC2	84071	broad.mit.edu	37	6	109249363	109249363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:109249363C>T	ENST00000392644.4	+	11	1591	c.1423C>T	c.(1423-1425)Ccc>Tcc	p.P475S	ARMC2_ENST00000368972.3_Missense_Mutation_p.P310S	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	475							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		CAGTGCCCTTCCCCAGCTCTG	0.438000													19	113					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962862	69962862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69962862G>A	ENST00000305231.7	+	1	670	c.624G>A	c.(622-624)atG>atA	p.M208I	UGT2B7_ENST00000509763.1_Intron|UGT2B7_ENST00000508661.1_Missense_Mutation_p.M208I	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	208					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGACTTTCATGGAGAGGGTAA	0.358000													27	88					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756137	71756137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71756137G>A	ENST00000318442.5	-	2	1677	c.1187C>T	c.(1186-1188)tCc>tTc	p.S396F		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GTCGCACTCGGAGCAGTTGTA	0.602000													13	47					0	0	1	0	0
C10orf88	80007	broad.mit.edu	37	10	124692119	124692119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124692119G>A	ENST00000481909.1	-	6	1386	c.1162C>T	c.(1162-1164)Ctg>Ttg	p.L388L	C10orf88_ENST00000368891.5_5'UTR	NM_024942.3	NP_079218.2	Q9H8K7	CJ088_HUMAN	chromosome 10 open reading frame 88	388										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)	18		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		TTTTCCATCAGTTCCATATTT	0.308000													11	49					0	0	1	0	0
EFCAB3	146779	broad.mit.edu	37	17	60493656	60493656	+	Missense_Mutation	SNP	G	G	A	rs140338043	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60493656G>A	ENST00000450662.2	+	12	1510	c.1439G>A	c.(1438-1440)aGa>aAa	p.R480K	EFCAB3_ENST00000305286.3_Missense_Mutation_p.R428K	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	428							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			GGAAGAAAAAGAAAACGGAAA	0.333000													33	104					0	0	1	0	0
TMEM161A	54929	broad.mit.edu	37	19	19231957	19231957	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19231957G>A	ENST00000450333.2	-	8	661	c.624C>T	c.(622-624)ttC>ttT	p.F208F	TMEM161A_ENST00000162044.9_Silent_p.F311F|TMEM161A_ENST00000587583.2_Silent_p.F286F	NM_001256766.1	NP_001243695.1	Q9NX61	T161A_HUMAN	transmembrane protein 161A	311					cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			GCCCAGAGTCGAAGGCAGAAT	0.697000													6	21					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121344402	121344402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121344402C>T	ENST00000297848.3	+	41	4952	c.4682C>T	c.(4681-4683)tCc>tTc	p.S1561F	COL14A1_ENST00000309791.4_Missense_Mutation_p.S1561F|COL14A1_ENST00000247781.3_Missense_Mutation_p.S1466F	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1561	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AAGGATGGATCCTCGGGACCT	0.463000													19	43					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196952140	196952140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196952140C>T	ENST00000367414.5	+	2	312	c.256C>T	c.(256-258)Cct>Tct	p.P86S	CFHR5_ENST00000256785.4_Missense_Mutation_p.P62S	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	62	Sushi 2.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						TTTTGTGTCTCCTTCAAAATC	0.393000													33	90					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96080179	96080179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96080179G>A	ENST00000297954.4	+	30	6764	c.6764G>A	c.(6763-6765)aGa>aAa	p.R2255K	WNK2_ENST00000395475.2_Intron|WNK2_ENST00000349097.3_Intron|WNK2_ENST00000356055.3_Intron|WNK2_ENST00000427277.2_Intron|WNK2_ENST00000471076.1_Intron|WNK2_ENST00000395477.2_Intron			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	2255					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						ACCGCCCGGAGAAACCAGGTG	0.682000													9	15					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60711215	60711215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60711215C>T	ENST00000227880.3	-	3	1175	c.942G>A	c.(940-942)gtG>gtA	p.V314V		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	314					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						GCAAGATCTTCACCAGCACCT	0.617000													5	14					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7254675	7254675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7254675G>A	ENST00000545280.1	-	2	96	c.80C>T	c.(79-81)tCg>tTg	p.S27L	C1RL_ENST00000545337.1_Silent_p.F103F|C1RL_ENST00000266542.4_Silent_p.F103F|C1RL_ENST00000544702.1_Silent_p.F103F			Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	0					complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CCGAACCGACGAATGAGATCT	0.607000													53	111					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21221496	21221496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21221496C>T	ENST00000574002.1	-	4	651	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K	ZP2_ENST00000219593.4_Missense_Mutation_p.E57K|ZP2_ENST00000574091.1_Missense_Mutation_p.E57K			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	57					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		ATTTCCCTTTCATCGCAAGTG	0.478000													25	78					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100189522	100189522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100189522G>A	ENST00000241071.6	+	4	877	c.555G>A	c.(553-555)aaG>aaA	p.K185K	FBXO24_ENST00000468962.1_Silent_p.K173K|FBXO24_ENST00000465843.1_Silent_p.K171K|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000360609.2_Silent_p.K171K|FBXO24_ENST00000427939.2_Silent_p.K223K	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	185						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GTGGAGCCAAGGATGTGAGTA	0.552000													20	73					0	0	1	0	0
IFNA10	3446	broad.mit.edu	37	9	21207021	21207021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21207021G>A	ENST00000357374.2	-	1	121	c.76C>T	c.(76-78)Ctg>Ttg	p.L26L		NM_002171.1	NP_002162.1	P01566	IFN10_HUMAN	interferon, alpha 10	26					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|large_intestine(3)|liver(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		GTCTGAGGCAGATCACAGCCT	0.493000													10	87					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43153697	43153697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43153697C>T	ENST00000252050.4	+	4	839	c.755C>T	c.(754-756)cCa>cTa	p.P252L	CUL9_ENST00000372647.2_Missense_Mutation_p.P252L|CUL9_ENST00000354495.3_Missense_Mutation_p.P252L	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	252					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						TTACAGATCCCAGGAAAGCTG	0.507000													19	48					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1248754	1248754	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1248754C>T	ENST00000348261.5	+	6	1031	c.783C>T	c.(781-783)ttC>ttT	p.F261F	CACNA1H_ENST00000565831.1_Silent_p.F261F|CACNA1H_ENST00000358590.4_Silent_p.F261F	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	261					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ACCGCTGCTTCCTGGACAGTG	0.632000													5	22					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	71004250	71004250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:71004250C>T	ENST00000357250.6	-	5	474	c.316G>A	c.(316-318)Gga>Aga	p.G106R	COL9A1_ENST00000370496.3_Missense_Mutation_p.G106R	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	106	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						TCAGGCAGTCCACTGGGATAT	0.388000													47	81					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28802509	28802509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:28802509G>A	ENST00000422425.2	+	23	1578	c.1534G>A	c.(1534-1536)Gaa>Aaa	p.E512K	PLB1_ENST00000329020.6_Missense_Mutation_p.E189K|PLB1_ENST00000327757.5_Missense_Mutation_p.E501K	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	501	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					ACACTTTCAGGAAGACTGGAA	0.423000													46	76					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149360587	149360587	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149360587C>T	ENST00000286298.4	+	3	1699	c.1431C>T	c.(1429-1431)tcC>tcT	p.S477S		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	477						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGTTCTATTCCCTTCAAAAAA	0.423000													5	82					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78223041	78223041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78223041G>A	ENST00000361193.3	+	16	1891	c.1611G>A	c.(1609-1611)caG>caA	p.Q537Q	SLC26A11_ENST00000572725.1_Silent_p.Q537Q|SLC26A11_ENST00000546047.2_Silent_p.Q537Q|SLC26A11_ENST00000411502.3_Silent_p.Q537Q	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	537	STAS.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AGCTCCTCCAGGACTTCCAGA	0.652000													10	32					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39895211	39895211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39895211G>A	ENST00000373186.4	-	1	244	c.107C>T	c.(106-108)cCt>cTt	p.P36L	MOCS1_ENST00000373188.2_Intron|MOCS1_ENST00000308559.7_Intron|MOCS1_ENST00000432280.2_Intron|MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000340692.5_Intron|MOCS1_ENST00000373175.4_Intron|MOCS1_ENST00000425303.2_Missense_Mutation_p.P36L	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	32	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGACAGACCAGGGAGGAAGCA	0.652000													5	14					0	0	1	0	0
CNPPD1	27013	broad.mit.edu	37	2	220037701	220037701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220037701G>A	ENST00000409789.1	-	9	1267	c.840C>T	c.(838-840)ccC>ccT	p.P280P	CNPPD1_ENST00000360507.5_Silent_p.P280P			Q9BV87	CNPD1_HUMAN	cyclin Pas1/PHO80 domain containing 1	280					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	12						AAGGTATGCAGGGCTCCAGGA	0.612000													11	136					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61310721	61310721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61310721G>A	ENST00000341074.5	-	2	206	c.91C>T	c.(91-93)Cct>Tct	p.P31S	SERPINB4_ENST00000356424.6_Missense_Mutation_p.P31S	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4									p.P31T(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						ATGCTGATAGGGGAATAGAAG	0.423000													39	184					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176295655	176295655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176295655C>T	ENST00000329542.4	+	4	804	c.530C>T	c.(529-531)cCt>cTt	p.P177L	UNC5A_ENST00000261961.3_Missense_Mutation_p.P137L	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	177	Ig-like C2-type.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGGGCATCCCTCCAGCCGAG	0.672000													3	6					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54792313	54792313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54792313G>A	ENST00000306858.7	+	4	733	c.617G>A	c.(616-618)cGa>cAa	p.R206Q		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	206										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TAGAATATTCGAGTGCGAACA	0.303000													16	86					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96034781	96034781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:96034781C>T	ENST00000358812.4	+	2	600	c.466C>T	c.(466-468)Cct>Tct	p.P156S	MANEA_ENST00000369293.1_Missense_Mutation_p.P156S	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	156	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		CAGCTTTTATCCTGAATTGGG	0.408000													59	118					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86252923	86252923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:86252923G>A	ENST00000314673.3	-	14	1542	c.1366C>T	c.(1366-1368)Cct>Tct	p.P456S	SNX14_ENST00000505648.1_Missense_Mutation_p.P404S|SNX14_ENST00000369627.2_Missense_Mutation_p.P456S|SNX14_ENST00000346348.3_Missense_Mutation_p.P412S|SNX14_ENST00000513865.1_Intron|SNX14_ENST00000508980.1_5'UTR	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	456	RGS.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CAGAACATAGGAGTAAATACA	0.323000													21	109					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232704	21232704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21232704C>T	ENST00000233242.1	-	26	7163	c.7036G>A	c.(7036-7038)Gag>Aag	p.E2346K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2346					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCATACCTCTCGATTAACTCA	0.373000													23	90					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914328	107914328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:107914328G>A	ENST00000280758.5	+	2	1728	c.1200G>A	c.(1198-1200)ggG>ggA	p.G400G	BTBD11_ENST00000420571.2_Silent_p.G400G|BTBD11_ENST00000490090.2_Silent_p.G400G	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	400						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						ACAAGCCAGGGGAACTGCCCA	0.552000													16	126					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78383099	78383099	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78383099C>T	ENST00000278550.7	-	31	6234	c.5772G>A	c.(5770-5772)tgG>tgA	p.W1924*		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		ATGTGTAGCTCCATGTCTTCC	0.547000													8	23					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99438729	99438729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99438729G>A	ENST00000397899.2	-	7	2338	c.2007C>T	c.(2005-2007)gcC>gcT	p.A669A		NM_207362.2	NP_997245.2			KIAA1211-like																		GCTCCTGGGCGGCTGGGCAGG	0.736000													3	17					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8218758	8218758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8218758G>A	ENST00000361926.3	+	7	1397	c.1287G>A	c.(1285-1287)gaG>gaA	p.E429E	ARHGEF15_ENST00000421050.1_Silent_p.E429E	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	429	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						TGACGTCCGAGGCTTCCTACC	0.622000													52	106					0	0	1	0	0
SLC26A10	65012	broad.mit.edu	37	12	58014179	58014179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58014179C>T	ENST00000379218.2	+	1	487	c.176C>T	c.(175-177)tCt>tTt	p.S59F	SLC26A10_ENST00000320442.4_Missense_Mutation_p.S59F			Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	59						integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					CTCTACACTTCTTTCTTCCCC	0.557000													159	551					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681068	142681068	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:142681068A>G	ENST00000340634.3	-	1	1110	c.1111T>C	c.(1111-1113)Tcc>Ccc	p.S371P		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	371						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						CAGAATTCGGAGCTGTTTAGG	0.537000													39	126					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142566816	142566816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142566816C>T	ENST00000392957.2	+	16	3160	c.2373C>T	c.(2371-2373)ttC>ttT	p.F791F	EPHB6_ENST00000442129.1_Silent_p.F791F|EPHB6_ENST00000411471.2_Silent_p.F514F	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	791	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GCTTTGCCTTCGTCCATCGCT	0.632000													10	38					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113208245	113208245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113208245G>A	ENST00000401783.2	-	26	4671	c.4335C>T	c.(4333-4335)ctC>ctT	p.L1445L	SVEP1_ENST00000374469.1_Silent_p.L1422L|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Silent_p.L1445L	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1445	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GGAGAGATGGGAGCATGCCAT	0.438000													13	45					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627663	43627663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:43627663C>T	ENST00000332857.6	-	4	1052	c.1024G>A	c.(1024-1026)Gaa>Aaa	p.E342K		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		TCTTTTTCTTCCCAAATGTTG	0.428000													29	126					0	0	1	0	0
RBP5	83758	broad.mit.edu	37	12	7280952	7280952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7280952G>A	ENST00000266560.3	-	2	302	c.136C>T	c.(136-138)Cag>Tag	p.Q46*	RBP5_ENST00000542370.1_Nonsense_Mutation_p.Q46*	NM_031491.2	NP_113679.1	P82980	RET5_HUMAN	retinol binding protein 5, cellular	46						cytoplasm	retinal binding|retinol binding|transporter activity			autonomic_ganglia(1)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)	10					Vitamin A(DB00162)	TGGTTGCCCTGGTGTTCGATC	0.582000													10	71					0	0	1	0	0
TRBV7-8	28590	broad.mit.edu	37	7	142099585	142099585	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142099585G>A	ENST00000390359.3	-	0	255																											TTGTCTAGTTGAGCTTCATTC	0.527000													17	61					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68748346	68748346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68748346G>A	ENST00000309106.3	-	1	109	c.110C>T	c.(109-111)aCc>aTc	p.T37I		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	37						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCACAGGCAGGTGAACATGGC	0.572000													27	52					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38412636	38412636	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38412636C>T	ENST00000322350.5	+	11	1726	c.1380C>T	c.(1378-1380)atC>atT	p.I460I	EGFLAM_ENST00000336740.6_Silent_p.I226I|EGFLAM_ENST00000397202.2_5'UTR|EGFLAM_ENST00000354891.3_Silent_p.I460I	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	460	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TTGCCATCATCGTAAGTGAGA	0.488000													44	83					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277763	114277763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114277763C>T	ENST00000357077.4	+	38	8042	c.7989C>T	c.(7987-7989)tcC>tcT	p.S2663S	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Silent_p.S2630S|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2630					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGTCTTCCTCCTCAGAAAGTG	0.478000													21	69					0	0	1	0	0
PTGES3L-AARSD1	100885850	broad.mit.edu	37	17	41108281	41108281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:41108281G>A	ENST00000421990.2	-	11	1470	c.1125C>T	c.(1123-1125)atC>atT	p.I375I	PTGES3L-AARSD1_ENST00000409399.1_Silent_p.I375I|PTGES3L-AARSD1_ENST00000409103.1_Silent_p.I284I|PTGES3L-AARSD1_ENST00000360221.4_Silent_p.I314I|AARSD1_ENST00000427569.2_Silent_p.I201I	NM_001136042.2	NP_001129514.2																					CAACGCCCTCGATGTTAACAA	0.547000													14	91					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11583189	11583189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11583189G>A	ENST00000262442.3	+	18	3537	c.3469G>A	c.(3469-3471)Gaa>Aaa	p.E1157K	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1157K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1157	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGCTGTTAAAGAACGGCAGAG	0.408000													48	88					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208133	140208133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140208133C>T	ENST00000529310.1	+	1	571	c.457C>T	c.(457-459)Cca>Tca	p.P153S	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.P153S|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGTGTTTCCACTGGAGGG	0.483000													38	134					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99439325	99439325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99439325C>T	ENST00000397899.2	-	7	1742	c.1411G>A	c.(1411-1413)Gga>Aga	p.G471R		NM_207362.2	NP_997245.2			KIAA1211-like																		GTCCCCGCTCCTCTCTCGGGC	0.756000													13	34					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63538522	63538522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:63538522G>A	ENST00000550760.3	+	4	1274	c.1095G>A	c.(1093-1095)ttG>ttA	p.L365L		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.L365F(1)		endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						ATATGGAATTGAGACCTTACA	0.393000													12	22					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57286838	57286838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57286838G>A	ENST00000391708.3	-	12	1344	c.802C>T	c.(802-804)Cct>Tct	p.P268S	ZIM2_ENST00000221722.5_Missense_Mutation_p.P268S|ZIM2_ENST00000601070.1_Missense_Mutation_p.P268S|ZIM2_ENST00000599935.1_Missense_Mutation_p.P268S|AC006115.3_ENST00000597946.1_RNA|ZIM2_ENST00000593711.1_Missense_Mutation_p.P268S|AC006115.3_ENST00000594400.1_RNA|AC006115.3_ENST00000595954.1_RNA	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		ATTGTTATAGGAGTCAAAAGT	0.443000													29	92					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103307750	103307750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:103307750G>A	ENST00000520539.1	-	30	4429	c.3823C>T	c.(3823-3825)Ctc>Ttc	p.L1275F	UBR5_ENST00000220959.4_Missense_Mutation_p.L1275F|UBR5_ENST00000521922.1_Missense_Mutation_p.L1269F	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1275					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AATAGTAAGAGGTGCTCTCCC	0.473000													37	74					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750008	142750008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142750008C>T	ENST00000418316.1	+	1	592	c.571C>T	c.(571-573)Cgc>Tgc	p.R191C		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					CTCTGACACTCGCCTGTTGGA	0.512000													59	164					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41385135	41385135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41385135G>A	ENST00000400454.1	-	33	6342	c.5865C>T	c.(5863-5865)tcC>tcT	p.S1955S		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1955				HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTCTCGTGGAGGAGGCGGAGG	0.637000													23	13					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71395335	71395335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:71395335G>A	ENST00000392650.3	-	22	3065	c.3065C>T	c.(3064-3066)tCc>tTc	p.S1022F	SDK2_ENST00000388726.3_Missense_Mutation_p.S1022F	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1022	Fibronectin type-III 5.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GCGGGAGATGGAGGTTTTCCC	0.637000													15	24					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66929360	66929360	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:66929360C>T	ENST00000269080.2	-	5	656	c.519G>A	c.(517-519)tgG>tgA	p.W173*	ABCA8_ENST00000586539.1_Nonsense_Mutation_p.W173*|ABCA8_ENST00000430352.2_Nonsense_Mutation_p.W173*	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	173						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					AACCTTCCTTCCAAAATACTG	0.303000													49	143					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150842658	150842658	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150842658G>A	ENST00000370357.4	+	15	2420	c.2175_splice	c.e15+1	p.Q725_splice		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	725						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CCTACCATCAGGTATGGGACA	0.562000													11	65					0	0	1	0	0
MRPS10	55173	broad.mit.edu	37	6	42179636	42179636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42179636G>A	ENST00000053468.3	-	4	221	c.206C>T	c.(205-207)cCa>cTa	p.P69L		NM_018141.3	NP_060611.2	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	69					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|lung(1)	2	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			TAATATGTCTGGTTCATCAGA	0.343000													6	87					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121997	50121997	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50121997G>A	ENST00000374160.3	-	1	280	c.204C>T	c.(202-204)tcC>tcT	p.S68S	WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron|RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Silent_p.S68S	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	68						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						ACTTGGAGATGGAGTCAGGGA	0.532000													11	43					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30033484	30033484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:30033484G>A	ENST00000328224.6	-	2	1975	c.742C>T	c.(742-744)Ccc>Tcc	p.P248S		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	248						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						ATATCAAAGGGGACATTGACT	0.488000													8	137					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176824006	176824006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176824006C>T	ENST00000324417.5	+	12	1438	c.1347C>T	c.(1345-1347)atC>atT	p.I449I	SLC34A1_ENST00000513614.1_3'UTR	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	449					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTCCAACATCGGCACCACCA	0.652000													16	42					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433089	104433089	+	Silent	SNP	G	G	A	rs143230604	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104433089G>A	ENST00000361820.3	-	3	2205	c.1605C>T	c.(1603-1605)ggC>ggT	p.G535G		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	535					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CAGGGCACAAGCCTTCATCAT	0.473000													34	55					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96702058	96702058	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96702058G>A	ENST00000260682.6	+	3	453	c.441G>A	c.(439-441)gaG>gaA	p.E147E	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	147					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GTGTTCAAGAGGAAGCCCGCT	0.502000													29	150					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97137245	97137245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:97137245G>A	ENST00000524981.3	+	20	2638	c.2638G>A	c.(2638-2640)Gac>Aac	p.D880N				Q6ZTY8	CL063_HUMAN		854										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						AAGCGCAGGGGACACGGAACT	0.413000													34	76					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28576899	28576899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28576899C>T	ENST00000434452.1	-	15	2505	c.2351G>A	c.(2350-2352)gGa>gAa	p.G784E	DSC3_ENST00000360428.4_Missense_Mutation_p.G784E	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	784					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding	p.G784E(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CTGGTTTCCTCCTTTCATCAT	0.498000													21	47					0	0	1	0	0
CMTM5	116173	broad.mit.edu	37	14	23846557	23846557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23846557C>T	ENST00000359320.3	+	1	541	c.97C>T	c.(97-99)Cac>Tac	p.H33Y	CMTM5_ENST00000342473.4_Missense_Mutation_p.H33Y|CMTM5_ENST00000397227.3_Missense_Mutation_p.H33Y|CMTM5_ENST00000382809.2_Missense_Mutation_p.H33Y|CMTM5_ENST00000339180.4_Missense_Mutation_p.H33Y|CMTM5_ENST00000555731.1_Missense_Mutation_p.H33Y	NM_138460.2	NP_612469.1	Q96DZ9	CKLF5_HUMAN	CKLF-like MARVEL transmembrane domain containing 5	33	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	8	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		CCTCACCTCCCACAAGGGCAT	0.647000													17	69					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807501	20807501	+	Silent	SNP	C	C	T	rs111500900		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:20807501C>T	ENST00000601440.1	-	4	1328	c.1182G>A	c.(1180-1182)gaG>gaA	p.E394E	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TGTAGGGTTTCTCTCCAGTAT	0.393000													25	85					0	0	1	0	0
B3GNT6	192134	broad.mit.edu	37	11	76750727	76750727	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76750727G>A	ENST00000421061.1	+	2	83		c.e2-1		B3GNT6_ENST00000533140.1_Silent_p.Q44Q|B3GNT6_ENST00000354301.5_Silent_p.Q44Q			Q6ZMB0	B3GN6_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)						O-glycan processing, core 3	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)|kidney(2)|lung(4)|prostate(1)	8						GGTCCCCGCAGGAGGAGACGC	0.716000											OREG0021252	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	25					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57013055	57013055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:57013055C>T	ENST00000370706.4	+	10	2416	c.2172C>T	c.(2170-2172)tgC>tgT	p.C724C	RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Silent_p.C724C|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|ZNF451_ENST00000491832.2_Silent_p.C724C|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	724					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CTTGTGGTTGCCGTGAGAGTT	0.358000													10	37					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102495982	102495982	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102495982G>A	ENST00000260228.2	-	1	81	c.69C>T	c.(67-69)gcC>gcT	p.A23A	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	23					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CTAGGGAGGGGGCTGCAGTGG	0.532000													11	73					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181386	140181386	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140181386C>T	ENST00000522353.2	+	1	604	c.604C>T	c.(604-606)Cga>Tga	p.R202*	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Nonsense_Mutation_p.R202*|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATTTAAATCGAGAGGACAC	0.363000													12	109					0	0	1	0	0
CASP4	837	broad.mit.edu	37	11	104817824	104817824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:104817824C>T	ENST00000444739.2	-	7	1931	c.1021G>A	c.(1021-1023)Gaa>Aaa	p.E341K	CASP4_ENST00000393150.3_Missense_Mutation_p.E285K	NM_001225.3	NP_001216.1	P49662	CASP4_HUMAN	caspase 4, apoptosis-related cysteine peptidase	341					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(2)	23		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		CGAAATACTTCCTCTAGGTGG	0.383000													44	124					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55136144	55136144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55136144G>A	ENST00000314706.3	+	1	785	c.785G>A	c.(784-786)cGa>cAa	p.R262Q		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						GAAGGGAAACGAAAAGCTTTC	0.438000													56	123					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156845925	156845925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156845925G>A	ENST00000368196.3	+	12	1657	c.1537G>A	c.(1537-1539)Ggc>Agc	p.G513S	NTRK1_ENST00000524377.1_Missense_Mutation_p.G519S|NTRK1_ENST00000358660.3_Missense_Mutation_p.G516S|NTRK1_ENST00000392302.2_Missense_Mutation_p.G483S	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	519	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GCTGGGGGAGGGCGCCTTTGG	0.637000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			9	92					0	0	1	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148715267	148715267	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:148715267G>A	ENST00000296721.4	+	18	2363	c.2265G>A	c.(2263-2265)agG>agA	p.R755R	AFAP1L1_ENST00000515000.1_Intron	NM_001146337.1|NM_152406.2	NP_001139809.1|NP_689619.1	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	755							protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCAAGGAAGGGTGCTACAGA	0.488000													39	111					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234749363	234749363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234749363G>A	ENST00000411486.2	-	8	2128	c.2063C>T	c.(2062-2064)cCc>cTc	p.P688L	HJURP_ENST00000432087.1_Missense_Mutation_p.P634L|HJURP_ENST00000441687.1_Missense_Mutation_p.P603L	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	688					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		GGAGCCCTGGGGTTCTGATAG	0.592000													29	100					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151916	158151916	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158151916C>T	ENST00000368171.3	+	4	922	c.423C>T	c.(421-423)atC>atT	p.I141I		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	141					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					GAAAAGATATCCTGAGTTTCC	0.517000													109	185					0	0	1	0	0
OSBPL6	114880	broad.mit.edu	37	2	179214050	179214050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179214050G>A	ENST00000190611.4	+	12	1463	c.1087G>A	c.(1087-1089)Gac>Aac	p.D363N	OSBPL6_ENST00000409631.1_Missense_Mutation_p.D363N|OSBPL6_ENST00000392505.2_Missense_Mutation_p.D388N|OSBPL6_ENST00000359685.3_Missense_Mutation_p.D363N|OSBPL6_ENST00000409045.3_Missense_Mutation_p.D332N|OSBPL6_ENST00000357080.4_Missense_Mutation_p.D332N|OSBPL6_ENST00000315022.2_Missense_Mutation_p.D367N	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	363					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CCACCTCACTGACCCTCTGGA	0.438000													70	171					0	0	1	0	0
ADCY3	109	broad.mit.edu	37	2	25057715	25057715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:25057715C>T	ENST00000260600.5	-	9	2604	c.1753G>A	c.(1753-1755)Gag>Aag	p.E585K	ADCY3_ENST00000405392.1_Missense_Mutation_p.E218K	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	585					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TGGTTGAGCTCGTGCTCATCT	0.662000													6	22					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164589	26164589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26164589G>A	ENST00000335473.7	+	4	956	c.706G>A	c.(706-708)Gag>Aag	p.E236K	MYO18B_ENST00000536101.1_Missense_Mutation_p.E236K|MYO18B_ENST00000407587.2_Missense_Mutation_p.E236K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	236						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AAAAGGCGAGGAGGGTCAAAG	0.627000													7	11					0	0	1	0	0
FOXR2	139628	broad.mit.edu	37	X	55650144	55650144	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:55650144G>A	ENST00000339140.3	+	0	312					NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2						embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						CTCCAGTAAAGATGGACTTAA	0.428000													5	32					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25005323	25005323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25005323C>T	ENST00000382114.4	-	8	1573	c.1388G>A	c.(1387-1389)gGg>gAg	p.G463E		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	463						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				GGTCATGGCCCCCCGGGATGG	0.507000													53	186					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149046	34149046	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34149046C>T	ENST00000346193.3	-	1	1401	c.1350G>A	c.(1348-1350)aaG>aaA	p.K450K		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	450										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						CCTTAGTTTTCTTCACCCGGG	0.552000													26	20					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94481369	94481369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94481369G>A	ENST00000370225.3	-	37	5324	c.5238C>T	c.(5236-5238)ttC>ttT	p.F1746F	ABCA4_ENST00000536513.1_Silent_p.F16F	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1746					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GAAACCCGATGAAGATGCCCA	0.517000													6	27					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75601331	75601331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:75601331C>T	ENST00000549446.1	-	2	1113	c.433G>A	c.(433-435)Gag>Aag	p.E145K	KCNC2_ENST00000341669.3_Missense_Mutation_p.E145K|KCNC2_ENST00000548513.1_Missense_Mutation_p.E145K|KCNC2_ENST00000550433.1_Missense_Mutation_p.E145K|KCNC2_ENST00000393288.2_Missense_Mutation_p.E145K|KCNC2_ENST00000350228.2_Missense_Mutation_p.E145K|KCNC2_ENST00000540018.1_Missense_Mutation_p.E145K|KCNC2_ENST00000298972.1_Missense_Mutation_p.E145K	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	145					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						ACGTCGGTCTCGTCGATGCCC	0.667000													16	38					0	0	1	0	0
NUCB2	4925	broad.mit.edu	37	11	17332408	17332408	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17332408C>A	ENST00000529010.1	+	7	739	c.520C>A	c.(520-522)Cat>Aat	p.H174N	NUCB2_ENST00000458064.2_Missense_Mutation_p.H174N|NUCB2_ENST00000323688.6_Missense_Mutation_p.H174N	NM_005013.2	NP_005004.1	P80303	NUCB2_HUMAN	nucleobindin 2	174						cytosol|ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|plasma membrane	calcium ion binding|DNA binding			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						CAAGACTCGTCATGAAGAATT	0.279000													47	106					1.21353e-23	1.22123e-23	1	1	0
PLA2G3	50487	broad.mit.edu	37	22	31533948	31533948	+	Missense_Mutation	SNP	G	G	A	rs145614024		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31533948G>A	ENST00000215885.3	-	4	1066	c.814C>T	c.(814-816)Cgc>Tgc	p.R272C		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	272	Phospholipase A2-like.				cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						GGCTGCAGGCGAGCGAGGGGC	0.647000													19	59					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353831	77353831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:77353831C>T	ENST00000282849.5	-	16	2865	c.2447G>A	c.(2446-2448)gGg>gAg	p.G816E		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	816	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AAACGTGGTCCCAGCGAAGGG	0.572000													12	82					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130501160	130501160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130501160C>T	ENST00000314830.8	-	12	2561	c.2448G>A	c.(2446-2448)acG>acA	p.T816T	SH2D3C_ENST00000420366.1_Silent_p.T658T|SH2D3C_ENST00000373274.3_Silent_p.T656T|SH2D3C_ENST00000373276.3_Silent_p.T748T|SH2D3C_ENST00000373277.4_Silent_p.T659T|SH2D3C_ENST00000429553.1_Silent_p.T462T	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	816	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCTGGAACTCCGTGCTGAACA	0.647000													4	9					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36500359	36500359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36500359C>T	ENST00000405275.2	+	17	1798	c.1555C>T	c.(1555-1557)Ccg>Tcg	p.P519S	CTNNBL1_ENST00000373469.1_Missense_Mutation_p.P294S|CTNNBL1_ENST00000373473.1_Missense_Mutation_p.P359S|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.P546S|CTNNBL1_ENST00000473857.1_3'UTR			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	546					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				CGGCCGGAGCCCGGAGTTCCG	0.597000													17	69					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12939478	12939478	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12939478G>A	ENST00000589272.1	-	5	783	c.454C>T	c.(454-456)Cag>Tag	p.Q152*	RTBDN_ENST00000393233.2_Silent_p.A78A|RTBDN_ENST00000322912.5_Nonsense_Mutation_p.Q152*|RTBDN_ENST00000458671.2_Nonsense_Mutation_p.Q120*|CTD-2265O21.3_ENST00000588469.1_RNA|RTBDN_ENST00000592204.1_Nonsense_Mutation_p.Q130*			Q9BSG5	RTBDN_HUMAN	retbindin	120						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						TACCAGGCCTGGCAGAGCTCC	0.652000													9	36					0	0	1	0	0
SCN2B	6327	broad.mit.edu	37	11	118039326	118039326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118039326C>T	ENST00000278947.5	-	2	452	c.211G>A	c.(211-213)Gag>Aag	p.E71K		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	71	Ig-like C2-type.				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		TTGTTGCACTCCTGGTAAGTC	0.597000													60	150					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51556768	51556768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:51556768G>A	ENST00000358559.2	+	3	214	c.127G>A	c.(127-129)Gga>Aga	p.G43R	MSMB_ENST00000474170.1_3'UTR|MSMB_ENST00000298239.6_Intron	NM_002443.3	NP_002434.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	43						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						GGATCTCAAAGGAAACAAACA	0.428000													19	48					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854284	40854284	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:40854284C>T	ENST00000254691.5	+	3	3049	c.2850C>T	c.(2848-2850)tcC>tcT	p.S950S	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	950					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						CCAACCCATCCACAGTCAAAC	0.498000													88	210					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039197	11039197	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11039197G>A	ENST00000470054.1	-	0	1006									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGATTCAATGACAAATTTTG	0.428000													18	419					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219499293	219499293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219499293G>A	ENST00000450993.2	+	13	2175	c.1836G>A	c.(1834-1836)caG>caA	p.Q612Q	PLCD4_ENST00000432688.1_Silent_p.Q644Q|PLCD4_ENST00000417849.1_Silent_p.Q612Q	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	612					intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GTGATATCCAGAGTTCTTTCC	0.498000													72	190					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98378568	98378568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98378568G>A	ENST00000186436.5	-	36	5047	c.4819C>T	c.(4819-4821)Ccc>Tcc	p.P1607S		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1607						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						GCAGCTGGGGGAGACGGGGAA	0.557000													17	36					0	0	1	0	0
PPCS	79717	broad.mit.edu	37	1	42925368	42925368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42925368C>T	ENST00000372561.3	+	3	714	c.707C>T	c.(706-708)cCc>cTc	p.P236L	PPCS_ENST00000455780.1_Missense_Mutation_p.P63L|PPCS_ENST00000372556.3_3'UTR|PPCS_ENST00000472013.1_3'UTR|PPCS_ENST00000372562.1_Missense_Mutation_p.P63L	NM_024664.2	NP_078940.2	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase	236					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|skin(3)	12	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAGACTGACCCCGCCATTGTA	0.403000													35	116					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542542	133542542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133542542C>T	ENST00000409261.1	-	14	2215	c.1842G>A	c.(1840-1842)gtG>gtA	p.V614V	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Silent_p.V614V	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	614							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CCAGGTTCTCCACGGACTTAT	0.483000													19	44					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50683792	50683792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:50683792G>A	ENST00000442544.2	+	8	1944	c.1328G>A	c.(1327-1329)cGa>cAa	p.R443Q	DCC_ENST00000581580.1_Missense_Mutation_p.R98Q|DCC_ENST00000412726.1_Missense_Mutation_p.R291Q	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	443	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.R443Q(2)		NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTTTCCAGCCGATTTGTCCGT	0.527000													44	170					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176795904	176795904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176795904C>T	ENST00000408923.3	+	9	1224	c.1036C>T	c.(1036-1038)Ctg>Ttg	p.L346L		NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	346	Necessary for interaction with RABGEF1 (By similarity).|RBD 1.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAAGGTCTACCTGGTGGGCAA	0.567000											OREG0017086	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	30					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	67017891	67017891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67017891C>T	ENST00000529006.2	+	17	2836	c.2390C>T	c.(2389-2391)tCg>tTg	p.S797L	KDM2A_ENST00000398645.2_Intron|KDM2A_ENST00000530342.1_Missense_Mutation_p.S358L|KDM2A_ENST00000308783.5_Missense_Mutation_p.S255L|KDM2A_ENST00000526258.1_3'UTR	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	797					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						ATCCGGGGATCGTACCTCACT	0.587000													28	75					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104176567	104176567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104176567G>A	ENST00000020673.5	-	2	755	c.229C>T	c.(229-231)Cgt>Tgt	p.R77C	PSD_ENST00000492902.2_5'UTR|PSD_ENST00000406432.1_Missense_Mutation_p.R77C	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	77	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGAGCAACACGGGGTGAGGGG	0.672000													32	68					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64507629	64507629	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64507629G>A	ENST00000377494.1	-	5	1300	c.378C>T	c.(376-378)acC>acT	p.T126T	RASGRP2_ENST00000394432.3_Silent_p.T126T|RASGRP2_ENST00000377497.3_Silent_p.T126T|RASGRP2_ENST00000354024.3_Silent_p.T126T			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	126	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TCCACTTGTAGGTAGGGCTGG	0.597000													25	67					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38783393	38783393	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38783393G>A	ENST00000359357.3	+	24	3086	c.2832G>A	c.(2830-2832)gtG>gtA	p.V944V	DNAH8_ENST00000441566.1_Silent_p.V944V|DNAH8_ENST00000449981.2_Silent_p.V1161V					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTACTGACGTGACCCATCAAA	0.453000													12	49					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111156421	111156421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111156421C>T	ENST00000280325.4	+	4	500	c.353C>T	c.(352-354)cCt>cTt	p.P118L		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	118										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CTCAGCCAGCCTGACCCTGTG	0.597000													37	60					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143080913	143080913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:143080913G>A	ENST00000367603.2	-	9	7254	c.6512C>T	c.(6511-6513)cCt>cTt	p.P2171L	HIVEP2_ENST00000012134.2_Missense_Mutation_p.P2171L|HIVEP2_ENST00000367604.1_Missense_Mutation_p.P2171L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	2171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ACTTACAGGAGGCCCCAATAC	0.433000													20	65					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48734526	48734526	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48734526C>T	ENST00000285238.8	+	4	548	c.468C>T	c.(466-468)atC>atT	p.I156I	ABCC3_ENST00000427699.1_Silent_p.I156I	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	156					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GCTCCAAGATCCTTTTAGCCA	0.567000													47	118					0	0	1	0	0
RECQL	5965	broad.mit.edu	37	12	21652496	21652496	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21652496G>A	ENST00000444129.2	-	2	477	c.9C>T	c.(7-9)tcC>tcT	p.S3S	RECQL_ENST00000421138.2_Silent_p.S3S	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	3					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						AACCTGAAACGGACGCCATTC	0.264000								Other identified genes with known or suspected DNA repair function					25	77					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114823558	114823558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114823558C>T	ENST00000315366.7	-	2	2538	c.1672G>A	c.(1672-1674)Gaa>Aaa	p.E558K	ARSJ_ENST00000541197.1_Missense_Mutation_p.E558K	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	558						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		ttcttggtttcctcttTATAC	0.448000													11	25					0	0	1	0	0
PRELP	5549	broad.mit.edu	37	1	203452401	203452401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203452401C>T	ENST00000343110.2	+	2	216	c.89C>T	c.(88-90)aCt>aTt	p.T30I		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	30					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			AGACCCGGGACTGGGCCCGGG	0.647000													27	92					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21991358	21991358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21991358G>A	ENST00000327430.3	-	2	2798	c.2504C>T	c.(2503-2505)tCt>tTt	p.S835F	SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron|SALL2_ENST00000450879.2_Missense_Mutation_p.S698F	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	835							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		TGGCAAAGAAGACTGTTGAGT	0.567000													12	69					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282579	69282579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69282579G>A	ENST00000338352.2	+	1	239	c.205G>A	c.(205-207)Gac>Aac	p.D69N		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	69										autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						GTTCCAAGACGACAGTAGCAT	0.547000													12	8					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7050889	7050889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:7050889C>T	ENST00000389658.3	-	4	485	c.392G>A	c.(391-393)cGa>cAa	p.R131Q		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	131	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTTCCAGGTCGAGGGGCATT	0.463000													17	40					0	0	1	0	0
ADAL	161823	broad.mit.edu	37	15	43641199	43641199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43641199C>T	ENST00000422466.2	+	11	1302	c.728C>T	c.(727-729)tCc>tTc	p.S243F	ADAL_ENST00000562188.1_Missense_Mutation_p.S243F|ADAL_ENST00000428046.3_Missense_Mutation_p.S216F|ADAL_ENST00000389651.4_Missense_Mutation_p.S243F			Q6DHV7	ADAL_HUMAN	adenosine deaminase-like	243					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding			endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)	7		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GAGGGAGGATCCCTGGATCTG	0.488000													31	61					0	0	1	0	0
P2RY12	64805	broad.mit.edu	37	3	151056222	151056222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151056222G>A	ENST00000302632.3	-	3	711	c.412C>T	c.(412-414)Ctc>Ttc	p.L138F	MED12L_ENST00000491549.1_Intron|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	138					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	GCCCCCAAGAGATTTTTGGGG	0.423000													34	81					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124390561	124390561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124390561G>A	ENST00000338354.3	+	46	5829	c.5723G>A	c.(5722-5724)gGg>gAg	p.G1908E	DMBT1_ENST00000344338.3_Missense_Mutation_p.G1898E|DMBT1_ENST00000368955.3_Missense_Mutation_p.G1898E|DMBT1_ENST00000359586.6_Missense_Mutation_p.G628E|DMBT1_ENST00000330163.4_Missense_Mutation_p.G1280E|DMBT1_ENST00000368956.2_Missense_Mutation_p.G1280E|DMBT1_ENST00000368909.3_Missense_Mutation_p.G1908E			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1908	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGCACCTGGGGGACAGTTTGT	0.478000													17	39					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37414539	37414539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37414539C>T	ENST00000535679.1	-	2	270	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K	SULT6B1_ENST00000407963.1_Missense_Mutation_p.E53K|SULT6B1_ENST00000260637.3_Missense_Mutation_p.E53K|SULT6B1_ENST00000379149.2_Missense_Mutation_p.E91K			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	91						cytoplasm	sulfotransferase activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				ACTGGGAATTCTGGATATTTA	0.323000													7	62					0	0	1	0	0
KBTBD11	9920	broad.mit.edu	37	8	1950790	1950790	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:1950790G>A	ENST00000320248.3	+	2	2398	c.1432G>A	c.(1432-1434)Gac>Aac	p.D478N		NM_014867.2	NP_055682.1	O94819	KBTBB_HUMAN	kelch repeat and BTB (POZ) domain containing 11	478										lung(1)|pancreas(1)	2		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.72e-05)|READ - Rectum adenocarcinoma(644;0.0929)|COAD - Colon adenocarcinoma(149;0.134)		CCCGCGGCGCGACGAGTGGCA	0.682000													5	20					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37346438	37346438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:37346438G>A	ENST00000373091.3	-	3	363	c.347C>T	c.(346-348)tCc>tTc	p.S116F	GRIK3_ENST00000373093.4_Missense_Mutation_p.S116F	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	116					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	ATTGGTGCAGGAGCCCTGTGA	0.632000													13	20					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6440044	6440044	+	Silent	SNP	C	C	T	rs104895272		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6440044C>T	ENST00000162749.2	-	6	899	c.600G>A	c.(598-600)gaG>gaA	p.E200E	TNFRSF1A_ENST00000540022.1_Silent_p.E157E	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	200					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						CCTTAACATTCTCAATCTGGG	0.552000													13	41					0	0	1	0	0
LETM2	137994	broad.mit.edu	37	8	38258410	38258410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:38258410C>T	ENST00000379957.4	+	6	950	c.823C>T	c.(823-825)Cgc>Tgc	p.R275C	LETM2_ENST00000528827.1_3'UTR|RP11-350N15.3_ENST00000533301.1_RNA|LETM2_ENST00000523983.2_Missense_Mutation_p.R228C|LETM2_ENST00000524874.1_Missense_Mutation_p.R227C|LETM2_ENST00000297720.5_Missense_Mutation_p.R180C|LETM2_ENST00000527710.1_Missense_Mutation_p.R61C	NM_001199659.1	NP_001186588.1	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane protein 2	275	LETM1.					integral to membrane|mitochondrial inner membrane				NS(1)|large_intestine(1)|lung(3)|prostate(2)	7	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			GGAGATAGTTCGCTTCTCCAA	0.463000													61	107					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82131753	82131753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82131753G>A	ENST00000199936.4	+	5	1069	c.876G>A	c.(874-876)caG>caA	p.Q292Q	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	292					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	CTGAGGTACAGGAAGACTACG	0.537000													25	79					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681119	100681119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100681119C>T	ENST00000306151.4	+	3	6486	c.6422C>T	c.(6421-6423)tCa>tTa	p.S2141L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2141	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGTCAGTTCATCTCCTATA	0.502000													117	368					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139113660	139113660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139113660G>A	ENST00000358701.5	-	6	840	c.803C>T	c.(802-804)tCg>tTg	p.S268L		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	268					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		CAATCCATGCGACCCATTTGG	0.557000													27	58					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49444380	49444380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49444380G>A	ENST00000301067.7	-	11	2990	c.2991C>T	c.(2989-2991)ccC>ccT	p.P997P		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGATCATAGGGGGGACAGGCT	0.617000													10	31					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294729	124294729	+	Silent	SNP	G	G	A	rs151066825		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124294729G>A	ENST00000356130.3	-	1	60	c.39C>T	c.(37-39)atC>atT	p.I13I		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		ATCCCACAAGGATAAACTCAG	0.488000													13	51					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76449531	76449531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76449531C>T	ENST00000389840.5	-	65	10505	c.10381G>A	c.(10381-10383)Gag>Aag	p.E3461K	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.E3470K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATGGCCTGCTCGATGACATCC	0.607000													7	42					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43247047	43247047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43247047G>A	ENST00000255226.6	+	13	2521	c.1705G>A	c.(1705-1707)Gag>Aag	p.E569K	SLC14A2_ENST00000586448.1_Missense_Mutation_p.E569K|SLC14A2_ENST00000589658.1_Missense_Mutation_p.E46K	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	569						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGAGTGTGGAGAGGGACTTAA	0.507000													5	37					0	0	1	0	0
BPIFA1	51297	broad.mit.edu	37	20	31825928	31825928	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31825928C>T	ENST00000354297.4	+	3	299	c.228C>T	c.(226-228)atC>atT	p.I76I	BPIFA1_ENST00000375422.2_Silent_p.I76I|BPIFA1_ENST00000375413.4_Silent_p.I76I	NM_130852.2	NP_570913.1	Q9NP55	PLUNC_HUMAN	BPI fold containing family A, member 1	76					innate immune response	extracellular region	lipid binding										TCCTGGACATCCTGAAGCCTG	0.562000													28	75					0	0	1	0	0
KITLG	4254	broad.mit.edu	37	12	88926235	88926235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:88926235G>A	ENST00000347404.5	-	3	747	c.175C>T	c.(175-177)Ccc>Tcc	p.P59S	KITLG_ENST00000357116.4_Intron|KITLG_ENST00000228280.5_Missense_Mutation_p.P59S|KITLG_ENST00000378535.4_5'UTR	NM_003994.5	NP_003985.2	P21583	SCF_HUMAN	KIT ligand	59					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)	9						TCCATCCCGGGGACATATTTG	0.328000									Testicular Cancer, Familial Clustering of				39	116					0	0	1	0	0
SLC5A3	6526	broad.mit.edu	37	21	35467931	35467931	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:35467931C>T	ENST00000381151.3	+	2	946	c.434C>T	c.(433-435)tCg>tTg	p.S145L	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	145						integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						GATCTGTATTCGGGTGCCCTT	0.468000													49	238					0	0	1	0	0
HAP1	9001	broad.mit.edu	37	17	39883338	39883338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39883338C>T	ENST00000393939.2	-	8	1268	c.1259G>A	c.(1258-1260)aGg>aAg	p.R420K	HAP1_ENST00000310778.5_Missense_Mutation_p.R497K|HAP1_ENST00000347901.4_Missense_Mutation_p.R445K|HAP1_ENST00000341193.5_Missense_Mutation_p.R428K|JUP_ENST00000540235.1_Intron			P54257	HAP1_HUMAN	huntingtin-associated protein 1	422	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TGAGATCATCCTCCTTAGAGA	0.572000													6	7					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158974353	158974353	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158974353C>T	ENST00000605860.1	+	7	574	c.528C>T	c.(526-528)ccC>ccT	p.P176P	UPP2_ENST00000460456.1_Intron|UPP2_ENST00000005756.4_Silent_p.P119P|UPP2_ENST00000409859.4_Silent_p.P176P			O95045	UPP2_HUMAN	uridine phosphorylase 2	119					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						TGGGCATCCCCTCCATTTCTA	0.413000													12	105					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15562664	15562664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15562664C>T	ENST00000343625.6	-	18	3058	c.2978G>A	c.(2977-2979)gGg>gAg	p.G993E		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	993					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						ACTCCAAGACCCCCGCGTCCT	0.607000													30	57					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111097299	111097299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:111097299G>A	ENST00000262839.2	-	4	1854	c.936C>T	c.(934-936)gcC>gcT	p.A312A		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	312					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ACCACAGGGTGGCAAGCAACT	0.488000													9	5					0	0	1	0	0
CDRT1	374286	broad.mit.edu	37	17	15492462	15492462	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:15492462G>A	ENST00000395906.3	-	12	2085	c.2086C>T	c.(2086-2088)Cag>Tag	p.Q696*	CDRT1_ENST00000583965.1_3'UTR|RP11-385D13.1_ENST00000455584.2_Intron|CDRT1_ENST00000354433.3_Nonsense_Mutation_p.Q196*	NM_006382.3	NP_006373.2	O95170	CDRT1_HUMAN	CMT1A duplicated region transcript 1	696										endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|stomach(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		TTTCCTCCCTGAGCTGTAGCA	0.517000													37	48					0	0	1	0	0
ST8SIA2	8128	broad.mit.edu	37	15	92988086	92988086	+	Missense_Mutation	SNP	G	G	A	rs147607028	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:92988086G>A	ENST00000268164.3	+	5	1006	c.769G>A	c.(769-771)Gag>Aag	p.E257K	ST8SIA2_ENST00000539113.1_Missense_Mutation_p.E236K	NM_006011.3	NP_006002.1	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	257					axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			GTGGGTCAACGAGCTTATCCT	0.642000													38	75					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50332845	50332845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50332845G>A	ENST00000394697.2	+	8	1319	c.979G>A	c.(979-981)Ggc>Agc	p.G327S	ADCY7_ENST00000254235.3_Missense_Mutation_p.G327S|ADCY7_ENST00000537579.1_Missense_Mutation_p.G327S|ADCY7_ENST00000564044.1_3'UTR|ADCY7_ENST00000566433.2_Missense_Mutation_p.G327S|ADCY7_ENST00000538642.1_Missense_Mutation_p.G327S			P51828	ADCY7_HUMAN	adenylate cyclase 7	327	Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CAAGATCCTCGGCGACTGCTA	0.627000													21	79					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103442096	103442096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103442096G>A	ENST00000361246.2	-	11	1720	c.1432C>T	c.(1432-1434)Ctc>Ttc	p.L478F		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	478					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GAATTGCTGAGGGCCCGAGAT	0.517000													14	222					0	0	1	0	0
CRTC2	200186	broad.mit.edu	37	1	153925837	153925837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153925837G>A	ENST00000368633.1	-	6	639	c.512C>T	c.(511-513)tCt>tTt	p.S171F	CRTC2_ENST00000476883.1_5'UTR|CRTC2_ENST00000368630.3_Intron	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	171					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCAGAGTCAGAGCTTGTCCT	0.587000													17	71					0	0	1	0	0
ACAD11	84129	broad.mit.edu	37	3	132298345	132298345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:132298345G>A	ENST00000264990.6	-	14	2650	c.1679C>T	c.(1678-1680)tCt>tTt	p.S560F	ACAD11_ENST00000355458.3_Missense_Mutation_p.S560F|ACAD11_ENST00000545291.1_Missense_Mutation_p.S85F	NM_032169.4	NP_115545.3			acyl-CoA dehydrogenase family, member 11											breast(2)|endometrium(6)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	36						CCTGGAGAGAGAAGTATTTTG	0.373000													17	79					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201287786	201287786	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201287786G>A	ENST00000263946.3	+	6	1346	c.1095G>A	c.(1093-1095)gaG>gaA	p.E365E	PKP1_ENST00000475988.1_3'UTR|PKP1_ENST00000352845.3_Silent_p.E365E|PKP1_ENST00000367324.3_Silent_p.E365E	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	365					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						AGCTGAAGGAGGAACTCATTG	0.597000													13	46					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1331458	1331458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1331458C>T	ENST00000381567.3	-	1	69	c.70G>A	c.(70-72)Gga>Aga	p.G24R	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Missense_Mutation_p.G24R	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	24						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CCTGCTCCTCCTTGCCCCAAA	0.488000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								8	34					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	993927	993927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:993927C>T	ENST00000537687.1	+	19	5380	c.4737C>T	c.(4735-4737)ccC>ccT	p.P1579P	WNK1_ENST00000530271.2_Silent_p.P1817P|WNK1_ENST00000340908.4_Silent_p.P912P|WNK1_ENST00000535572.1_Silent_p.P1072P|WNK1_ENST00000315939.6_Silent_p.P1319P	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1319					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CAGAAGGACCCAACACAGCAC	0.483000													43	99					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215263	140215263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140215263C>T	ENST00000525929.1	+	1	1295	c.1295C>T	c.(1294-1296)tCg>tTg	p.S432L	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.S432L|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGGGGGCTCGCCTTCTCTG	0.622000													54	142					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25439060	25439060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:25439060G>A	ENST00000278886.6	-	22	3875	c.3802C>T	c.(3802-3804)Ctt>Ttt	p.L1268F	NINL_ENST00000464285.1_5'UTR|NINL_ENST00000422516.1_Missense_Mutation_p.L919F	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	1268					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						TCTCCCTGAAGGCTGAGCAGG	0.687000													11	58					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294042	25294042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25294042C>T	ENST00000400358.4	+	19	2183	c.2126C>T	c.(2125-2127)tCc>tTc	p.S709F	SGSM1_ENST00000400359.4_Missense_Mutation_p.S764F	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	764	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						GGCACTTGTTCCCCAGACTCG	0.562000													6	50					0	0	1	0	0
TANGO2	128989	broad.mit.edu	37	22	20043519	20043519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20043519C>T	ENST00000327374.4	+	6	612	c.434C>T	c.(433-435)cCt>cTt	p.P145L	TANGO2_ENST00000432883.1_Intron|TANGO2_ENST00000447208.2_Missense_Mutation_p.P145L|TANGO2_ENST00000420290.2_Missense_Mutation_p.P47L|TANGO2_ENST00000434570.2_Missense_Mutation_p.P186L|TANGO2_ENST00000401886.1_Intron|TANGO2_ENST00000401833.1_Missense_Mutation_p.P186L|TANGO2_ENST00000456048.1_Missense_Mutation_p.P150L|TANGO2_ENST00000398042.2_Intron	NM_152906.4	NP_690870.3			transport and golgi organization 2 homolog (Drosophila)																		GAGCCTGATCCTATCGTTTTG	0.567000													20	36					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60699279	60699279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60699279G>A	ENST00000005286.4	+	6	1291	c.1138G>A	c.(1138-1140)Gaa>Aaa	p.E380K	TMEM132A_ENST00000453848.2_Missense_Mutation_p.E379K	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	379						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						CCAGGCCCCTGAAGCAGAGAA	0.592000													48	101					0	0	1	0	0
MFSD2A	84879	broad.mit.edu	37	1	40424494	40424494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40424494C>T	ENST00000372809.5	+	3	532	c.389C>T	c.(388-390)cCc>cTc	p.P130L	MFSD2A_ENST00000420632.2_Intron|MFSD2A_ENST00000372811.5_Missense_Mutation_p.P117L	NM_001136493.1	NP_001129965.1	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing 2A	130					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						CGCCTTATGCCCTGGTGAGTA	0.582000													81	177					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730674	57730674	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57730674G>A	ENST00000281282.5	+	2	555	c.477G>A	c.(475-477)aaG>aaA	p.K159K		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	159	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		ACCCTGAAAAGAATGAGTTGA	0.433000													16	87					0	0	1	0	0
DPEP3	64180	broad.mit.edu	37	16	68011711	68011711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68011711G>A	ENST00000268793.4	-	6	1226	c.853C>T	c.(853-855)Cgc>Tgc	p.R285C		NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	260					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		ATGCCCAGGCGGTTCAACTCC	0.498000													18	23					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8499829	8499829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8499829G>A	ENST00000381196.4	-	22	2683	c.2140C>T	c.(2140-2142)Cct>Tct	p.P714S	PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.P714S|PTPRD_ENST00000360074.4_Missense_Mutation_p.P701S|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.P701S|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.P714S|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000397606.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	714	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTGCGAGGAGGACCACTAGGA	0.443000										TSP Lung(15;0.13)			8	61					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766837	77766837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77766837C>T	ENST00000521891.2	+	10	8128	c.7680C>T	c.(7678-7680)ccC>ccT	p.P2560P	ZFHX4_ENST00000455469.2_Silent_p.P2515P|ZFHX4_ENST00000050961.6_Silent_p.P2515P|ZFHX4_ENST00000518282.1_Silent_p.P2534P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2515						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTCAAATGCCCCCTCAGGCCA	0.498000										HNSCC(33;0.089)			17	63					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62026827	62026827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62026827G>A	ENST00000578147.1	-	15	2991	c.2915C>T	c.(2914-2916)cCc>cTc	p.P972L	SCN4A_ENST00000435607.1_Missense_Mutation_p.P972L			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	972					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CTCCTCGGGGGGCTTGTAGTC	0.642000													4	17					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139096	90139096	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90139096G>A	ENST00000492446.1	+	0	19																											GACCCAGTCAGGACACAGCAT	0.547000													46	191					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739263	55739263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55739263G>A	ENST00000370830.3	-	1	1099	c.401C>T	c.(400-402)cCt>cTt	p.P134L	BMP5_ENST00000446683.2_Missense_Mutation_p.P134L	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	134					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GGTGGTCAGAGGAGTCGTCCG	0.512000													24	92					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49049243	49049243	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49049243C>T	ENST00000395474.3	+	2	646	c.366C>T	c.(364-366)ctC>ctT	p.L122L	WDR6_ENST00000489684.1_Intron|WDR6_ENST00000448293.1_Silent_p.L41L|WDR6_ENST00000415265.2_Intron	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	92					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		GCAAGGGACTCCGAGTTGTGA	0.557000													60	155					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182007	57182007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:57182007G>A	ENST00000504228.1	+	6	2444	c.2339G>A	c.(2338-2340)cGg>cAg	p.R780Q	KIAA1211_ENST00000264229.6_Missense_Mutation_p.R780Q|KIAA1211_ENST00000541073.1_Missense_Mutation_p.R773Q			Q6ZU35	K1211_HUMAN	KIAA1211	780										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GAGATGCACCGGGAGCCCGCA	0.617000													23	73					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12666901	12666901	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12666901C>T	ENST00000425538.1	+	14	3101	c.2901C>T	c.(2899-2901)ttC>ttT	p.F967F	RP11-1090M7.1_ENST00000584772.1_RNA|MYOCD_ENST00000343344.4_Silent_p.F919F	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	919					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACATCGATTTCCTGGATGTCA	0.517000													17	26					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189931480	189931480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189931480C>T	ENST00000374866.3	-	22	1704	c.1430G>A	c.(1429-1431)gGa>gAa	p.G477E		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	477					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCCAGCTTCTCCTTTGAAACC	0.378000													45	113					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711060	41711060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41711060C>T	ENST00000400454.1	-	7	1970	c.1493G>A	c.(1492-1494)cGa>cAa	p.R498Q		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	498	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TACGTTTATTCGAGCCTGGTA	0.522000													17	60					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	921174	921174	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:921174G>A	ENST00000262301.11	-	7	1083	c.1065C>T	c.(1063-1065)ccC>ccT	p.P355P	LMF1_ENST00000399843.2_Silent_p.P355P|LMF1_ENST00000543238.1_Silent_p.P118P|LMF1_ENST00000568897.1_Silent_p.P138P|LMF1_ENST00000568268.1_5'UTR	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	355						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				ATCTGGGCTCGGGCCGGGCCC	0.667000													3	4					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125989084	125989084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:125989084G>A	ENST00000319286.5	+	3	728	c.574G>A	c.(574-576)Gaa>Aaa	p.E192K		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CCAGTGTGGTGAATGTGGGAA	0.443000										HNSCC(60;0.17)			40	81					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65055925	65055925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65055925C>T	ENST00000298705.1	+	12	1234	c.1138C>T	c.(1138-1140)Ctt>Ttt	p.L380F	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	380																	GCTTCACCCCCTTGATCCAGA	0.428000													21	77					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176760486	176760486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176760486C>T	ENST00000367662.3	+	19	6052	c.4888C>T	c.(4888-4890)Ccc>Tcc	p.P1630S		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1630	Sushi 4.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						ATTCTAGCTTCCCATCCTCTG	0.408000													13	49					0	0	1	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733072	56733072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56733072G>A	ENST00000587340.1	-	7	2058	c.1363C>T	c.(1363-1365)Ctg>Ttg	p.L455L	ZSCAN5A_ENST00000391713.1_Silent_p.L455L|ZSCAN5A_ENST00000592355.1_Silent_p.L454L|ZSCAN5A_ENST00000587492.1_Silent_p.L309L|ZSCAN5A_ENST00000254165.3_Silent_p.L338L			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	455					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TGCTCCTTCAGGCTCCCCCTG	0.507000													19	49					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62675553	62675553	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62675553G>A	ENST00000498273.1	+	4	1402	c.1107G>A	c.(1105-1107)gaG>gaA	p.E369E		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	369	Glu-rich.									breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						CTAAGCCAGAGGAGATGAAAA	0.438000													30	139					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138452929	138452929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:138452929G>A	ENST00000344876.4	-	1	700	c.314C>T	c.(313-315)tCc>tTc	p.S105F	PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.S105F|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	105	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					AAACTCTATGGAACAGTTCAA	0.413000													65	174					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640681	104640681	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104640681A>T	ENST00000304883.2	-	1	292	c.152T>A	c.(151-153)cTc>cAc	p.L51H		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	51						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGAGGAGGAGAGGTTGCCAGC	0.701000													25	43					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57330049	57330049	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57330049C>A	ENST00000326441.9	-	8	1054	c.691G>T	c.(691-693)Gtg>Ttg	p.V231L	ZIM2_ENST00000221722.5_Missense_Mutation_p.V106L|ZIM2_ENST00000601070.1_Missense_Mutation_p.V106L|ZIM2_ENST00000599935.1_Missense_Mutation_p.V106L|PEG3_ENST00000598410.1_Missense_Mutation_p.V106L|PEG3_ENST00000593695.1_Missense_Mutation_p.V105L|ZIM2_ENST00000593711.1_Missense_Mutation_p.V106L|ZIM2_ENST00000391708.3_Missense_Mutation_p.V106L|PEG3_ENST00000423103.2_Missense_Mutation_p.V231L	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	231					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGGTCCACCACATTTTGGTAT	0.483000													29	83					1.21669e-08	1.22088e-08	1	1	0
SLC31A1	1317	broad.mit.edu	37	9	116018469	116018469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116018469C>T	ENST00000374212.4	+	2	193	c.41C>T	c.(40-42)tCc>tTc	p.S14F	SLC31A1_ENST00000374210.6_Missense_Mutation_p.S14F|CDC26_ENST00000490408.1_Intron	NM_001859.3	NP_001850.1	O15431	COPT1_HUMAN	solute carrier family 31 (copper transporter), member 1	14						integral to plasma membrane	copper ion transmembrane transporter activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7						TATATGGACTCCAACAGTACC	0.438000													20	60					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70953128	70953128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70953128C>T	ENST00000334414.6	-	18	4753	c.4709G>A	c.(4708-4710)aGg>aAg	p.R1570K	PTPRB_ENST00000550358.1_Missense_Mutation_p.R1482K|PTPRB_ENST00000551525.1_Missense_Mutation_p.R1569K|PTPRB_ENST00000261266.5_Missense_Mutation_p.R1352K|PTPRB_ENST00000451516.2_Missense_Mutation_p.R1262K|PTPRB_ENST00000538708.1_Missense_Mutation_p.R1262K|PTPRB_ENST00000550857.1_Missense_Mutation_p.R1262K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1352					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CATACTTGTCCTCACAGATCC	0.383000													62	127					0	0	1	0	0
F2RL3	9002	broad.mit.edu	37	19	17001309	17001309	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17001309C>T	ENST00000248076.3	+	2	1365	c.1035C>T	c.(1033-1035)gcC>gcT	p.A345A		NM_003950.2	NP_003941.2	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	345					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						ACGTGTCGGCCGAGTTCAGGG	0.672000													6	31					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41510233	41510233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41510233G>A	ENST00000324071.4	+	3	373	c.366G>A	c.(364-366)aaG>aaA	p.K122K	CYP2B6_ENST00000330446.5_Silent_p.K82K|CYP2B6_ENST00000598834.1_3'UTR|CYP2B6_ENST00000593831.1_Silent_p.K46K	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	122					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ACCGCTGGAAGGTGCTTCGGC	0.552000													10	37					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4231288	4231288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4231288C>T	ENST00000221847.5	+	2	221	c.168C>T	c.(166-168)tcC>tcT	p.S56S		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	56	Fibronectin type-III 1.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCAAACTCCACCAGCCCCG	0.657000													4	27					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17507491	17507491	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17507491A>T	ENST00000229922.2	+	5	924	c.392A>T	c.(391-393)aAt>aTt	p.N131I	CAP2_ENST00000493172.1_Intron|CAP2_ENST00000465994.1_Missense_Mutation_p.N131I|CAP2_ENST00000489374.1_Intron|CAP2_ENST00000378990.2_Missense_Mutation_p.N105I	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	131					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			AACATGTTTAATCATCTTTCG	0.488000													35	68					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47500803	47500803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47500803G>A	ENST00000285039.7	-	10	1538	c.1239C>T	c.(1237-1239)ttC>ttT	p.F413F		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	413	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CAATCCAGCCGAACAACTGGG	0.592000													39	66					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	158074052	158074052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:158074052G>A	ENST00000264428.4	+	9	1357	c.1087G>A	c.(1087-1089)Gaa>Aaa	p.E363K	GLRB_ENST00000541722.1_Intron|GLRB_ENST00000512619.1_Intron|GLRB_ENST00000509282.1_Missense_Mutation_p.E363K	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	363					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GGTTGAAGCTGAAAAAGCCAG	0.448000													15	51					0	0	1	0	0
ELOVL2	54898	broad.mit.edu	37	6	10995328	10995328	+	Silent	SNP	C	C	T	rs141887901		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:10995328C>T	ENST00000354666.3	-	5	500	c.417G>A	c.(415-417)acG>acA	p.T139T		NM_017770.3	NP_060240.3	Q9NXB9	ELOV2_HUMAN	ELOVL fatty acid elongase 2	139					fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|stomach(1)|upper_aerodigestive_tract(2)	14	Breast(50;0.0418)|Ovarian(93;0.0919)	all_hematologic(90;0.117)	Epithelial(50;0.176)			TAATCTGACTCGTTTTTTTCC	0.358000													49	110					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20548670	20548670	+	Silent	SNP	C	C	T	rs71811918		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20548670C>T	ENST00000329697.6	-	14	1812	c.1644G>A	c.(1642-1644)ttG>ttA	p.L548L	ACSM2B_ENST00000565322.1_Silent_p.L469L|ACSM2B_ENST00000567001.1_Silent_p.L548L|ACSM2B_ENST00000565232.1_Silent_p.L548L	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	548					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TGGGCAGGTTCAAGACAAACT	0.493000													85	162					0	0	1	0	0
ARL5B	221079	broad.mit.edu	37	10	18964126	18964126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:18964126C>T	ENST00000377275.3	+	6	754	c.521C>T	c.(520-522)tCc>tTc	p.S174F		NM_178815.3	NP_848930.1	Q96KC2	ARL5B_HUMAN	ADP-ribosylation factor-like 5B	174					small GTPase mediated signal transduction	intracellular	GTP binding			lung(1)|ovary(1)	2						TGGATGACCTCCCGGATTGGT	0.343000													11	84					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	66048628	66048628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:66048628G>A	ENST00000443035.3	-	3	376	c.161C>T	c.(160-162)tCt>tTt	p.S54F	DENND4A_ENST00000431932.2_Missense_Mutation_p.S54F	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	54	MABP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						CTCCCCAAGAGATTTGATAAT	0.378000													7	35					0	0	1	0	0
HMGN4	10473	broad.mit.edu	37	6	26545639	26545639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:26545639C>T	ENST00000377575.2	+	2	382	c.205C>T	c.(205-207)Cct>Tct	p.P69S		NM_006353.2	NP_006344.1	O00479	HMGN4_HUMAN	high mobility group nucleosomal binding domain 4	69						chromatin|nucleus	DNA binding			lung(2)|skin(1)	3						TGGGAACAACCCTGCAAAAAA	0.493000													33	93					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169548310	169548310	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:169548310C>T	ENST00000340806.6	+	3	1225	c.1225C>T	c.(1225-1227)Cat>Tat	p.H409Y		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	409										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						AGAGAACAATCATCTGGAGTA	0.383000													4	15					0	0	1	0	0
MAP4K5	11183	broad.mit.edu	37	14	50912805	50912805	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:50912805G>A	ENST00000013125.4	-	17	1495	c.1177C>T	c.(1177-1179)Cct>Tct	p.P393S		NM_006575.4|NM_198794.2	NP_006566.2|NP_942089.1	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase kinase 5	393					activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_epithelial(31;0.000415)|Breast(41;0.0102)					ACCTTAGGAGGTAGGGGAGGT	0.284000													5	35					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159584018	159584018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159584018C>T	ENST00000337808.6	+	3	1403	c.826C>T	c.(826-828)Cca>Tca	p.P276S	IQCJ-SCHIP1_ENST00000476809.1_Missense_Mutation_p.P325S|IQCJ-SCHIP1_ENST00000460298.1_Missense_Mutation_p.P236S|SCHIP1_ENST00000482804.1_Missense_Mutation_p.P49S|IQCJ-SCHIP1_ENST00000485419.1_Missense_Mutation_p.P352S|SCHIP1_ENST00000445224.2_Missense_Mutation_p.P33S|IQCJ-SCHIP1_ENST00000412423.2_Missense_Mutation_p.P263S|IQCJ-SCHIP1_ENST00000527095.1_Missense_Mutation_p.P44S	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		276						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						TGATGATGGCCCAGGAATTTA	0.398000													59	165					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119966478	119966478	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119966478C>T	ENST00000327554.2	+	12	1753	c.1288C>T	c.(1288-1290)Caa>Taa	p.Q430*	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	430										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CTCAAATTTTCAAAAGGACAT	0.398000													52	112					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50957857	50957857	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50957857C>T	ENST00000374103.4	-	8	987	c.902G>A	c.(901-903)aGg>aAg	p.R301K	OGDHL_ENST00000419399.1_Missense_Mutation_p.R244K|OGDHL_ENST00000432695.1_Missense_Mutation_p.R92K	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	301					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CACGTTCAGCCTTCCCCTGGA	0.667000													7	12					0	0	1	0	0
DPRX	503834	broad.mit.edu	37	19	54140039	54140039	+	Nonsense_Mutation	SNP	C	C	T	rs150237904		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54140039C>T	ENST00000376650.1	+	3	424	c.373C>T	c.(373-375)Cga>Tga	p.R125*		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	125						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		CACGGGTCATCGAGTCCCCTC	0.567000													12	99					0	0	1	0	0
LONRF3	79836	broad.mit.edu	37	X	118145875	118145875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:118145875C>T	ENST00000365713.2	+	7	1790	c.1627C>T	c.(1627-1629)Cgt>Tgt	p.R543C	LONRF3_ENST00000371628.3_Missense_Mutation_p.R584C|LONRF3_ENST00000422289.2_Missense_Mutation_p.R328C|LONRF3_ENST00000472173.1_3'UTR|LONRF3_ENST00000304778.7_Missense_Mutation_p.R543C			Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger 3	584					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	36						CCTGATGATTCGTAGATGCAT	0.493000													51	37					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796874	62796874	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62796874G>A	ENST00000582986.1	-	0	1046					NR_024386.1																						GACTCACAGCGAAGCAGGGAG	0.627000													10	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596949	179596949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179596949C>T	ENST00000589042.1	-	57	16971	c.16747G>A	c.(16747-16749)Gaa>Aaa	p.E5583K	TTN_ENST00000342992.6_Missense_Mutation_p.E4339K|TTN_ENST00000591111.1_Missense_Mutation_p.E5266K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5266	Ig-like 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTAATTTCTCTATCATTT	0.428000													48	154					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132193081	132193081	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:132193081C>T	ENST00000359827.3	-	2	1334	c.372G>A	c.(370-372)gaG>gaA	p.E124E	PLXNA4_ENST00000423507.2_Silent_p.E124E|PLXNA4_ENST00000321063.4_Silent_p.E124E|PLXNA4_ENST00000378539.5_Silent_p.E124E			Q9HCM2	PLXA4_HUMAN	plexin A4	124	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCAGCCTGTTCTCCTTGTAGT	0.547000													16	54					0	0	1	0	0
HERC6	55008	broad.mit.edu	37	4	89304376	89304376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89304376C>T	ENST00000380265.5	+	2	386	c.203C>T	c.(202-204)cCa>cTa	p.P68L	HERC6_ENST00000264346.7_Missense_Mutation_p.P68L|HERC6_ENST00000273960.3_Missense_Mutation_p.P68L	NM_001165136.1	NP_001158608.1	Q8IVU3	HERC6_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	68					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		CCCAAAGAACCAATTCAGGCA	0.453000													3	13					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191233	152191233	+	Missense_Mutation	SNP	C	C	T	rs138860104	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152191233C>T	ENST00000368801.2	-	3	2947	c.2872G>A	c.(2872-2874)Gaa>Aaa	p.E958K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	958					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGTGTTGTTCGTAGCTGGAG	0.552000													135	331					0	0	1	0	0
KYNU	8942	broad.mit.edu	37	2	143712381	143712381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:143712381G>A	ENST00000264170.4	+	5	634	c.376G>A	c.(376-378)Gcc>Acc	p.A126T	KYNU_ENST00000409512.1_Missense_Mutation_p.A126T|KYNU_ENST00000375773.2_Missense_Mutation_p.A126T	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	126					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity	p.A126T(1)		large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTTACAGGAGCCAATGAGAA	0.299000													27	68					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973592	29973592	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:29973592G>A	ENST00000378993.1	+	11	2419	c.1746G>A	c.(1744-1746)ggG>ggA	p.G582G	IL1RAPL1_ENST00000302196.4_Silent_p.G582G	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	582	Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						GGCCTTTTGGGGAGCTGCAGA	0.512000													12	13					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38485983	38485983	+	Missense_Mutation	SNP	C	C	T	rs143995164		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38485983C>T	ENST00000263409.4	-	17	2597	c.2435G>A	c.(2434-2436)cGa>cAa	p.R812Q	LIFR_ENST00000453190.2_Missense_Mutation_p.R812Q	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	812	Fibronectin type-III 6.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity	p.R812Q(2)		NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TGTATAGGCTCGCAAGACCAG	0.433000			T	PLAG1	salivary adenoma								21	63					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48602074	48602074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48602074C>T	ENST00000340553.3	+	7	1049	c.788C>T	c.(787-789)cCt>cTt	p.P263L		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	263					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			AAGCCTCTTCCTCTTAAAACA	0.378000													13	63					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	38997691	38997691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:38997691C>T	ENST00000400482.3	-	4	1631	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	KCNJ6_ENST00000288309.6_Missense_Mutation_p.E348K	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	348					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	TAGTCAACTTCGTAGAACCCG	0.567000													20	77					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15655019	15655019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15655019G>A	ENST00000269703.2	+	10	1264	c.1065G>A	c.(1063-1065)ccG>ccA	p.P355P	CYP4F22_ENST00000601005.2_Silent_p.P355P	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	355						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						CAAAGTATCCGGAATACCAGG	0.537000													39	75					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72349019	72349019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72349019G>A	ENST00000389916.4	+	15	2178	c.2040G>A	c.(2038-2040)ctG>ctA	p.L680L		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	680					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						ATTCTGACCTGGAGAGTGTGA	0.597000													32	82					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59189495	59189495	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59189495C>T	ENST00000302040.4	-	1	954	c.932G>A	c.(931-933)gGg>gAg	p.G311E		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						GTGAGAAATCCCGGGGTCCCT	0.413000													48	113					0	0	1	0	0
NDUFB7	4713	broad.mit.edu	37	19	14682756	14682756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14682756G>A	ENST00000215565.2	-	1	118	c.57C>T	c.(55-57)ccC>ccT	p.P19P		NM_004146.5	NP_004137.2	P17568	NDUB7_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa	19					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8					NADH(DB00157)	GCATCTGCAGGGGGTCGGGCT	0.716000													4	15					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587807	247587807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247587807C>T	ENST00000366497.2	+	4	1842	c.1062C>T	c.(1060-1062)gcC>gcT	p.A354A	NLRP3_ENST00000391828.3_Silent_p.A354A|NLRP3_ENST00000336119.3_Silent_p.A354A|NLRP3_ENST00000391827.2_Silent_p.A354A|NLRP3_ENST00000348069.2_Silent_p.A354A|NLRP3_ENST00000366496.2_Silent_p.A354A|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	354	NACHT.		A -> V (in MWS).		detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GACCTGTGGCCCTGGAGAAAC	0.557000													7	93					0	0	1	0	0
ADGRE4P	326342	broad.mit.edu	37	19	6981116	6981116	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6981116C>T	ENST00000600751.1	-	0	563					NR_024075.1																						AAATTTGACCCTTTCCTGGAG	0.443000													9	15					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45384947	45384947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45384947G>A	ENST00000559488.1	+	14	2261	c.2245G>A	c.(2245-2247)Gac>Aac	p.D749N	ITGB3_ENST00000560629.1_Missense_Mutation_p.R737Q|RP11-290H9.4_ENST00000575039.1_RNA|ITGB3_ENST00000435993.2_Missense_Mutation_p.D702N	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	749					activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	CACCATCCACGACCGAAAAGA	0.537000													18	27					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11572916	11572916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11572916C>T	ENST00000262442.3	+	17	3226	c.3158C>T	c.(3157-3159)cCc>cTc	p.P1053L	DNAH9_ENST00000454412.2_Missense_Mutation_p.P1053L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1053	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAGAACCCTCCCCTCCTTTCT	0.507000													37	77					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43808945	43808945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43808945G>A	ENST00000403856.1	-	9	803	c.656C>T	c.(655-657)tCc>tTc	p.S219F	THADA_ENST00000404790.1_Missense_Mutation_p.S219F|THADA_ENST00000402360.2_Missense_Mutation_p.S219F|THADA_ENST00000415080.2_5'UTR|THADA_ENST00000405006.4_Missense_Mutation_p.S219F|THADA_ENST00000405975.2_Missense_Mutation_p.S219F			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	219							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GGGAGAATCGGAAGTCTTCCA	0.333000													18	73					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26877949	26877949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26877949C>T	ENST00000374168.2	+	5	523	c.369C>T	c.(367-369)ttC>ttT	p.F123F	RPS6KA1_ENST00000530003.1_Silent_p.F107F|RPS6KA1_ENST00000531382.1_Silent_p.F132F|RPS6KA1_ENST00000526792.1_Silent_p.F31F|RPS6KA1_ENST00000374162.2_Silent_p.F31F|RPS6KA1_ENST00000374166.4_Silent_p.F123F	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	123	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		ATCACCCATTCGTGGTGAAGC	0.567000													12	31					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17548851	17548851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17548851C>T	ENST00000005226.7	-	5	414	c.415G>A	c.(415-417)Gga>Aga	p.G139R	USH1C_ENST00000318024.4_Missense_Mutation_p.G139R|USH1C_ENST00000527720.1_Missense_Mutation_p.G108R|USH1C_ENST00000527020.1_Missense_Mutation_p.G139R	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	139	PDZ 1.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						ATGGAATATCCATTGATCCGG	0.547000													22	67					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175682	143175682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143175682C>T	ENST00000408916.1	+	1	717	c.717C>T	c.(715-717)ttC>ttT	p.F239F	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	239					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TCATCTCCTTCCTCATTCTTT	0.512000													43	84					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69972933	69972933	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69972933G>A	ENST00000305231.7	+	4	1089	c.1043G>A	c.(1042-1044)gGt>gAt	p.G348D	UGT2B7_ENST00000509763.1_3'UTR|UGT2B7_ENST00000508661.1_Missense_Mutation_p.G348D	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	348					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GATACCTTAGGTCTCAATACT	0.358000													30	117					0	0	1	0	0
GJA1	2697	broad.mit.edu	37	6	121768083	121768083	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:121768083C>T	ENST00000282561.3	+	2	247	c.90C>T	c.(88-90)ttC>ttT	p.F30F		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	30					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CAGTACTTTTCATTTTCCGAA	0.532000													32	61					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170715801	170715801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170715801C>T	ENST00000314251.3	-	11	1545	c.1466G>A	c.(1465-1467)gGa>gAa	p.G489E	SLC2A2_ENST00000382808.4_Missense_Mutation_p.G370E	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	489					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			AAAAGACTTTCCTTTGGTTTC	0.438000													8	133					0	0	1	0	0
OR1J2	26740	broad.mit.edu	37	9	125273455	125273455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125273455C>T	ENST00000335302.5	+	1	375	c.375C>T	c.(373-375)gcC>gcT	p.A125A		NM_054107.1	NP_473448.1	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J, member 2	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						GATATGTTGCCATATGTCACC	0.423000													19	84					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166900519	166900519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166900519C>T	ENST00000423058.2	-	11	1720	c.1703G>A	c.(1702-1704)cGa>cAa	p.R568Q	SCN1A_ENST00000409050.1_Missense_Mutation_p.R568Q|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.R568Q|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.R568Q	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	568						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTGCTATTTCGCCTTGGTGA	0.418000													30	63					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158577148	158577148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158577148G>A	ENST00000361284.1	+	1	920	c.920G>A	c.(919-921)gGg>gAg	p.G307E		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					GCTTTCAGAGGGAGATTGCTG	0.468000													60	157					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	708645	708645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:708645G>A	ENST00000549091.1	+	23	2979	c.2887G>A	c.(2887-2889)Ggc>Agc	p.G963S	WDR90_ENST00000293879.4_Missense_Mutation_p.G963S	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	963										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GGCCAGCCCAGGCCCCCAGGT	0.697000													9	24					0	0	1	0	0
CHGA	1113	broad.mit.edu	37	14	93398965	93398965	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93398965G>A	ENST00000216492.5	+	7	1339	c.1059G>A	c.(1057-1059)acG>acA	p.T353T	CHGA_ENST00000334654.4_Silent_p.T202T	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	353					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		AGGAGCTGACGGCTGAGAAGC	0.657000													4	8					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8656896	8656896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8656896C>T	ENST00000270328.4	-	13	1945	c.1679G>A	c.(1678-1680)aGc>aAc	p.S560N	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.S560N|ADAMTS10_ENST00000595838.1_Missense_Mutation_p.A51T			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	560	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						ACAGGTCCGGCTGCAGTCGCC	0.711000													11	33					0	0	1	0	0
PCMTD2	55251	broad.mit.edu	37	20	62904588	62904588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62904588C>T	ENST00000308824.6	+	6	848	c.721C>T	c.(721-723)Cgc>Tgc	p.R241C	PCMTD2_ENST00000266078.6_Missense_Mutation_p.R17C|PCMTD2_ENST00000299468.7_Intron|PCMTD2_ENST00000369758.3_Missense_Mutation_p.R214C	NM_018257.2	NP_060727.2	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	241						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(9)|upper_aerodigestive_tract(1)	17	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGTGGCAGTTCGCAGCCTCCA	0.507000													18	69					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876420	35876420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35876420C>T	ENST00000303115.3	+	8	1341	c.1212C>T	c.(1210-1212)ctC>ctT	p.L404L	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	404					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ACCAGGACCTCCTGCTTAGCC	0.547000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						21	34					0	0	1	0	0
ARSI	340075	broad.mit.edu	37	5	149678054	149678054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149678054C>T	ENST00000328668.7	-	2	1012	c.433G>A	c.(433-435)Gtg>Atg	p.V145M		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	145						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CACTTGCCCACCATATGGGTG	0.612000													16	37					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118867030	118867030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:118867030G>A	ENST00000295622.1	+	2	1442	c.1402G>A	c.(1402-1404)Gaa>Aaa	p.E468K	RP11-484M3.5_ENST00000490594.1_Intron	NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	468										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		ATTTCAGGATGAATTTTCAGA	0.363000													45	123					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141012408	141012408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:141012408G>A	ENST00000277549.5	+	43	5939	c.3370G>A	c.(3370-3372)Gag>Aag	p.E1124K	CACNA1B_ENST00000371357.1_Missense_Mutation_p.E1929K|CACNA1B_ENST00000371363.1_Missense_Mutation_p.E1928K|CACNA1B_ENST00000277551.2_Missense_Mutation_p.E1930K|CACNA1B_ENST00000371355.4_Missense_Mutation_p.E1931K|CACNA1B_ENST00000371372.1_Missense_Mutation_p.E1930K			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1930					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	ACAAAACCAAGAGAGTGGCAT	0.567000													4	22					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152553713	152553713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152553713C>T	ENST00000427231.2	-	16	1621	c.1419G>A	c.(1417-1419)caG>caA	p.Q473Q	NEB_ENST00000604864.1_Silent_p.Q473Q|NEB_ENST00000603639.1_Silent_p.Q473Q|NEB_ENST00000172853.10_Silent_p.Q473Q|NEB_ENST00000397345.3_Silent_p.Q473Q|NEB_ENST00000409198.1_Silent_p.Q473Q	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	473					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GAGTTATGGTCTGAGGGAAGA	0.383000													13	61					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123428651	123428651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123428651G>A	ENST00000360772.3	-	15	2272	c.1894C>T	c.(1894-1896)Ctc>Ttc	p.L632F	MYLK_ENST00000360304.3_Missense_Mutation_p.L632F|MYLK_ENST00000475616.1_Missense_Mutation_p.L632F|MYLK_ENST00000346322.5_Missense_Mutation_p.L563F|MYLK_ENST00000359169.1_Missense_Mutation_p.L632F			Q15746	MYLK_HUMAN	myosin light chain kinase	632	Ig-like C2-type 5.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ATGACTTTGAGATCAGAGAGG	0.512000													78	360					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47210392	47210392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47210392G>A	ENST00000300404.2	+	1	64	c.5G>A	c.(4-6)gGg>gAg	p.G2E	B4GALNT2_ENST00000393354.2_Intron|B4GALNT2_ENST00000504681.1_Intron	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	2					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			CCAGGAATGGGGAGCGCTGGC	0.647000													8	17					0	0	1	0	0
EDEM1	9695	broad.mit.edu	37	3	5229451	5229451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:5229451C>T	ENST00000600805.1	-	1	531	c.532G>A	c.(532-534)Ggc>Agc	p.G178S	EDEM1_ENST00000256497.4_5'UTR																							GCGGGGAGGCCCCCGCGCTTT	0.687000													4	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604061	179604061	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179604061T>A	ENST00000589042.1	-	48	14123	c.13899A>T	c.(13897-13899)aaA>aaT	p.K4633N	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.K4316N|TTN_ENST00000342175.6_Missense_Mutation_p.K4462N|TTN_ENST00000359218.5_Missense_Mutation_p.K4395N|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K4270N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4316	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTCACCTCTTTAGCATTTG	0.368000													14	35					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072298	134072298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:134072298C>T	ENST00000264360.4	+	1	1829	c.1003C>T	c.(1003-1005)Ccc>Tcc	p.P335S		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	335	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		GGACCTGGGCCCCAACGCCGT	0.602000													20	123					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160783618	160783618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160783618C>T	ENST00000263285.5	+	3	677	c.647C>T	c.(646-648)cCa>cTa	p.P216L	LY9_ENST00000471816.1_3'UTR|LY9_ENST00000368041.2_Missense_Mutation_p.P176L|LY9_ENST00000341032.4_Missense_Mutation_p.P216L|LY9_ENST00000368040.1_5'UTR	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	216	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCATGTGACCCAGACCTGCCA	0.552000													65	230					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10468410	10468410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10468410G>A	ENST00000529370.1	-	17	2826	c.2496C>T	c.(2494-2496)ccC>ccT	p.P832P	TYK2_ENST00000264818.6_Intron|TYK2_ENST00000525621.1_Intron|TYK2_ENST00000524462.1_Intron			P29597	TYK2_HUMAN	tyrosine kinase 2	0	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCCCCACTGCGGGGAGGGCCC	0.612000													5	5					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229706	21229706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21229706G>A	ENST00000233242.1	-	26	10161	c.10034C>T	c.(10033-10035)tCa>tTa	p.S3345L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3345					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATGACACTTGATTTAAAGGA	0.368000													42	136					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36641014	36641014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36641014G>A	ENST00000373448.2	-	3	1443	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	TTI1_ENST00000373447.3_Missense_Mutation_p.S402F|TTI1_ENST00000449821.1_Missense_Mutation_p.S402F|TTI1_ENST00000487362.1_Intron	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	402							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AAGTAACAAGGAAAGAGTAGA	0.478000													45	84					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6587206	6587206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:6587206G>A	ENST00000321612.6	-	15	1935	c.1785C>T	c.(1783-1785)ttC>ttT	p.F595F		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	595					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAAGCTCTCGGAAAAGCTGCT	0.413000													35	62					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240341321	240341321	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240341321C>T	ENST00000319653.9	+	3	2113	c.1883C>T	c.(1882-1884)cCa>cTa	p.P628L	RP11-567G24.3_ENST00000412311.1_RNA|RP11-567G24.3_ENST00000444308.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	628					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ATGGGGCCACCATCCAAACCT	0.493000													17	60					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634324	180634324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:180634324G>A	ENST00000410066.1	-	3	762	c.159C>T	c.(157-159)tcC>tcT	p.S53S		NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	53						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			ATTTGCCGTTGGAATGCACCT	0.562000													19	65					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93528871	93528871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93528871C>T	ENST00000394196.4	+	26	4449	c.3381C>T	c.(3379-3381)ctC>ctT	p.L1127L	CHD2_ENST00000557381.1_Silent_p.L1127L	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1127					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GGAAGGACCTCGTGGAGGGAT	0.527000													82	137					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161173184	161173184	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161173184C>T	ENST00000308192.9	+	18	2226	c.2163C>T	c.(2161-2163)ctC>ctT	p.L721L		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	721	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AAGCCCAGCTCCCTGTGATTG	0.468000													17	39					0	0	1	0	0
TEX29	121793	broad.mit.edu	37	13	111992259	111992259	+	Silent	SNP	C	C	T	rs34403563	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111992259C>T	ENST00000283547.1	+	4	348	c.219C>T	c.(217-219)ttC>ttT	p.F73F		NM_152324.1	NP_689537.1	Q8N6K0	CM016_HUMAN	testis expressed 29	73						integral to membrane											CTGGGGCCTTCGTCATCACCA	0.522000													47	124					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76433779	76433779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76433779C>T	ENST00000389840.5	-	74	12083	c.11959G>A	c.(11959-11961)Gag>Aag	p.E3987K	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.E3988K					dynein, axonemal, heavy chain 17									p.E3988Q(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTGGGGGGCTCGTTGGTGATC	0.657000													17	29					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63047835	63047835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:63047835C>T	ENST00000561311.1	+	36	4811	c.4581C>T	c.(4579-4581)ttC>ttT	p.F1527F	TLN2_ENST00000306829.6_Silent_p.F1527F			Q9Y4G6	TLN2_HUMAN	talin 2	1527					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AGAGGCACTTCGTCCAGTCAG	0.562000													14	68					0	0	1	0	0
CGA	1081	broad.mit.edu	37	6	87796037	87796037	+	Silent	SNP	C	C	T	rs142907318		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:87796037C>T	ENST00000369582.2	-	3	304	c.204G>A	c.(202-204)aaG>aaA	p.K68K		NM_000735.3	NP_000726.1	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	68					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			NS(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)	15		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		ACATCGTCTTCTTGGACCTTA	0.493000													51	126					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30724930	30724930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30724930C>T	ENST00000262518.4	+	16	2776	c.2391C>T	c.(2389-2391)ttC>ttT	p.F797F	SRCAP_ENST00000344771.4_Silent_p.F797F|SRCAP_ENST00000395059.2_Silent_p.F797F	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	797					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCCATGTCTTCCAGTCTCATC	0.517000													41	148					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51975321	51975321	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51975321G>A	ENST00000220478.3	+	3	584	c.181_splice	c.e3+1	p.E61_splice	SCG3_ENST00000542355.2_5'UTR	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	61					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		ATATCCTCCAGGTAAAAAGAA	0.348000													56	118					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376321	113376321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113376321G>A	ENST00000316407.4	-	7	4618	c.4208C>T	c.(4207-4209)cCa>cTa	p.P1403L	KIAA2018_ENST00000478658.1_Missense_Mutation_p.P1403L|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1403					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GTTACTAGGTGGAAATAATCG	0.463000													16	58					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228525721	228525721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228525721G>A	ENST00000570156.2	+	78	19822	c.19748G>A	c.(19747-19749)gGc>gAc	p.G6583D	OBSCN_ENST00000366707.4_Missense_Mutation_p.G3260D|OBSCN_ENST00000422127.1_Missense_Mutation_p.G5626D|OBSCN_ENST00000284548.11_Missense_Mutation_p.G5626D|OBSCN_ENST00000366709.4_Missense_Mutation_p.G2745D	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5626	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGCGGGAAGGCCAGTATGTG	0.632000													9	12					0	0	1	0	0
BEX1	55859	broad.mit.edu	37	X	102318005	102318005	+	Missense_Mutation	SNP	C	C	T	rs1045082		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:102318005C>T	ENST00000372728.3	-	3	437	c.198G>A	c.(196-198)atG>atA	p.M66I		NM_018476.3	NP_060946.3	Q9HBH7	BEX1_HUMAN	brain expressed, X-linked 1	66			M -> I (in dbSNP:rs1045082).		cell differentiation|nervous system development	cytoplasm|nucleus				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12						GCCTATGCATCATATCCCATC	0.517000													117	62					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123498383	123498383	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123498383G>A	ENST00000280562.5	-	3	490	c.285C>T	c.(283-285)acC>acT	p.T95T	PITPNM2_ENST00000320201.4_Silent_p.T95T|PITPNM2_ENST00000546049.1_Silent_p.T95T|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Silent_p.T95T			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	95					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		ACCTGGTTCGGGTGTAGGGGT	0.602000													5	23					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21016731	21016731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21016731G>A	ENST00000247986.2	-	7	1641	c.1331C>T	c.(1330-1332)tCa>tTa	p.S444L	KIF17_ENST00000400463.3_Missense_Mutation_p.S444L|KIF17_ENST00000490034.1_5'UTR|KIF17_ENST00000375044.1_Missense_Mutation_p.S344L			Q9P2E2	KIF17_HUMAN	kinesin family member 17	444					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GACGTCATATGAGTTGCGCAT	0.627000													22	56					0	0	1	0	0
SEC14L3	266629	broad.mit.edu	37	22	30867933	30867933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30867933C>T	ENST00000215812.4	-	1	103	c.13G>A	c.(13-15)Gtt>Att	p.V5I	SEC14L3_ENST00000403066.1_5'UTR|SEC14L3_ENST00000402286.1_5'UTR|SEC14L3_ENST00000401751.1_5'UTR|SEC14L3_ENST00000539629.1_5'UTR	NM_174975.4	NP_777635.1	Q9UDX4	S14L3_HUMAN	SEC14-like 3 (S. cerevisiae)	5						integral to membrane|intracellular	lipid binding|transporter activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	AGGTCTCCAACTCGGCCGCTC	0.632000													39	82					0	0	1	0	0
MCHR2	84539	broad.mit.edu	37	6	100390947	100390947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:100390947C>T	ENST00000281806.2	-	4	779	c.465G>A	c.(463-465)ttG>ttA	p.L155L	MCHR2_ENST00000369212.1_Silent_p.L155L|MCHR2_ENST00000445970.1_Silent_p.L155L	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	155						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CCCAAAGGCCCAAATTGATCC	0.473000													38	86					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56477606	56477606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56477606G>A	ENST00000291971.3	+	5	2312	c.2241G>A	c.(2239-2241)ttG>ttA	p.L747L	NLRP8_ENST00000590542.1_Silent_p.L747L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	747						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GCACCATGTTGAACCAGGACT	0.493000													55	123					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416472	29416472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29416472C>T	ENST00000389048.3	-	29	5387	c.4481G>A	c.(4480-4482)gGa>gAa	p.G1494E	ALK_ENST00000431873.1_Missense_Mutation_p.G324E	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1494					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTTTCTGGATCCGTGGACCTT	0.527000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				32	129					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228402555	228402555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228402555C>T	ENST00000570156.2	+	5	1658	c.1584C>T	c.(1582-1584)tcC>tcT	p.S528S	OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Silent_p.S528S|OBSCN_ENST00000284548.11_Silent_p.S528S	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	528	Fibronectin type-III 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGGAGAGTTCCGTGATTCTCA	0.592000													10	19					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57268309	57268309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57268309G>A	ENST00000278426.3	-	5	763	c.408C>T	c.(406-408)ttC>ttT	p.F136F	SLC43A1_ENST00000528450.1_Silent_p.F136F	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	136					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						ACAGCGCCAGGAATATCAACG	0.587000													12	27					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58567466	58567466	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58567466C>T	ENST00000348616.4	+	10	1617	c.1317C>T	c.(1315-1317)gtC>gtT	p.V439V	CDH26_ENST00000244047.5_Silent_p.V439V	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	439	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CAAATTGGGTCAGCGTCGACA	0.383000													11	40					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408206	29408206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29408206G>A	ENST00000444197.2	+	1	1124	c.414G>A	c.(412-414)cgG>cgA	p.R138R	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	138			R -> W (in dbSNP:rs17177646).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TGAGCCACCGGGTGTGTCTAC	0.637000													8	65					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79454396	79454396	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:79454396T>G	ENST00000554719.1	+	12	2546	c.2055T>G	c.(2053-2055)tgT>tgG	p.C685W	NRXN3_ENST00000335750.5_Missense_Mutation_p.C685W	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		AAGATTCATGTGCCAACCAGG	0.433000													28	62					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170030438	170030438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170030438C>T	ENST00000263816.3	-	56	11290	c.11005G>A	c.(11005-11007)Gaa>Aaa	p.E3669K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3669	LDL-receptor class A 29.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGCATTCTTCAATGGGCTCA	0.557000													37	87					0	0	1	0	0
AMBP	259	broad.mit.edu	37	9	116837253	116837253	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116837253G>A	ENST00000265132.3	-	3	586	c.324C>T	c.(322-324)ctC>ctT	p.L108L		NM_001633.3	NP_001624.1	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin precursor	108					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	11					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	ATTTGTGATAGAGAAACTTCC	0.438000													10	99					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43325361	43325361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43325361G>A	ENST00000361428.2	-	3	768	c.691C>T	c.(691-693)Ctg>Ttg	p.L231L	ZNF318_ENST00000318149.3_Silent_p.L231L	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	231					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GATCGATGCAGGAAAGTTTCT	0.478000													28	92					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456633	5456633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5456633G>A	ENST00000222033.4	+	1	1208	c.1131G>A	c.(1129-1131)ccG>ccA	p.P377P		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	377						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CCTCCCTACCGGGCCACCGGC	0.682000													30	97					0	0	1	0	0
PIP4K2A	5305	broad.mit.edu	37	10	22839618	22839618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:22839618G>A	ENST00000376573.4	-	7	990	c.762C>T	c.(760-762)gtC>gtT	p.V254V	PIP4K2A_ENST00000323883.7_Silent_p.V114V|PIP4K2A_ENST00000545335.1_Silent_p.V195V	NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	254	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						TTTCCAGGAAGACCTTCTTGT	0.368000											OREG0020068	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	187					0	0	1	0	0
P2RX5-TAX1BP3	100533970	broad.mit.edu	37	17	3595085	3595085	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3595085C>T	ENST00000550383.1	-	2	329	c.141G>A	c.(139-141)tgG>tgA	p.W47*	P2RX5_ENST00000225328.5_Nonsense_Mutation_p.W47*|P2RX5_ENST00000547178.1_Nonsense_Mutation_p.W47*|P2RX5_ENST00000551178.1_Nonsense_Mutation_p.W47*|P2RX5_ENST00000552276.1_Nonsense_Mutation_p.W47*|P2RX5_ENST00000435558.1_Nonsense_Mutation_p.W47*|P2RX5_ENST00000345901.3_Nonsense_Mutation_p.W47*|P2RX5_ENST00000552050.1_Nonsense_Mutation_p.W11*																							TCAGGAACACCCATCTGTGGG	0.597000													30	77					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	420556	420556	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:420556C>T	ENST00000432829.2	+	31	4108	c.3792C>T	c.(3790-3792)ttC>ttT	p.F1264F	DOCK8_ENST00000493666.2_3'UTR|DOCK8_ENST00000453981.1_Silent_p.F1332F|DOCK8_ENST00000469391.1_Silent_p.F1232F|DOCK8_ENST00000382329.1_Silent_p.F799F	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1332					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ATCTACTTTTCATCTGTGTGT	0.418000													42	76					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54903535	54903535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54903535C>T	ENST00000293373.6	+	6	668	c.589C>T	c.(589-591)Cac>Tac	p.H197Y	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.H147Y	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	197					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GTTTGGGCCTCACACAAAGGC	0.488000													21	187					0	0	1	0	0
PNISR	25957	broad.mit.edu	37	6	99851719	99851719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:99851719G>A	ENST00000369239.5	-	10	1346	c.1142C>T	c.(1141-1143)tCc>tTc	p.S381F	PNISR_ENST00000438806.1_Missense_Mutation_p.S381F	NM_032870.2	NP_116259.2	Q8TF01	PNISR_HUMAN	PNN-interacting serine/arginine-rich protein	381						nuclear speck				breast(2)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24						TCCAGTGAGGGAAGCCAGTGC	0.428000													10	23					0	0	1	0	0
TPPP3	51673	broad.mit.edu	37	16	67424131	67424131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67424131G>A	ENST00000564104.1	-	3	1318	c.477C>T	c.(475-477)ggC>ggT	p.G159G	TPPP3_ENST00000290942.5_Silent_p.G159G|TPPP3_ENST00000562206.1_Silent_p.G159G|TPPP3_ENST00000393957.2_Silent_p.G159G			Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family member 3	159					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)	7		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		CGCTCACGTAGCCACTGTCGT	0.627000													15	73					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137748500	137748500	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:137748500A>T	ENST00000413152.2	+	1	39	c.39A>T	c.(37-39)aaA>aaT	p.K13N	THSD7B_ENST00000272643.3_Intron|THSD7B_ENST00000409968.1_Intron	NM_001080427.1	NP_001073896.1			thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGTATCACAAATTAGCAGGTA	0.393000													6	5					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35700223	35700223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35700223G>A	ENST00000314888.9	-	49	6978	c.6625C>T	c.(6625-6627)Cgc>Tgc	p.R2209C	TLN1_ENST00000540444.1_Missense_Mutation_p.R2097C	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	2209					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ATAGCACGGCGGCTCAGATTG	0.537000													9	79					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51900434	51900434	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51900434G>A	ENST00000371117.3	-	28	3458	c.3183C>T	c.(3181-3183)gtC>gtT	p.V1061V	PKHD1_ENST00000340994.4_Silent_p.V1061V	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1061	IPT/TIG 5.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TGCTTGTAGCGACATTGATGG	0.453000													30	117					0	0	1	0	0
DPF3	8110	broad.mit.edu	37	14	73159785	73159785	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:73159785C>T	ENST00000541685.1	-	7	753	c.742_splice	c.e7+1	p.R247_splice	DPF3_ENST00000556509.1_Splice_Site_p.R247_splice|DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000546183.1_Splice_Site_p.R257_splice	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	247					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GGCACTCACGCCTGTGGTTCT	0.552000													26	236					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171178038	171178038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171178038C>T	ENST00000441535.1	+	9	1479	c.1362C>T	c.(1360-1362)ttC>ttT	p.F454F	RP1-127D3.4_ENST00000422841.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000209929.7_Silent_p.F454F|RP1-127D3.4_ENST00000445290.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	454					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTCTCTTGTTCAAAGATCCTA	0.502000													102	205					0	0	1	0	0
ZNF260	339324	broad.mit.edu	37	19	37005709	37005709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37005709G>A	ENST00000523638.1	-	3	1553	c.432C>T	c.(430-432)gcC>gcT	p.A144A	ZNF260_ENST00000593142.1_Silent_p.A144A|ZNF260_ENST00000592282.1_Silent_p.A144A|ZNF260_ENST00000588993.1_Silent_p.A144A	NM_001166036.1|NM_001166037.1|NM_001166038.1	NP_001159508.1|NP_001159509.1|NP_001159510.1	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	144					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)	15	Esophageal squamous(110;0.162)					TGCCGTTAAAGGCTTTGCCAC	0.393000													75	166					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628817	71628817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71628817C>T	ENST00000377276.2	-	1	222	c.192G>A	c.(190-192)caG>caA	p.Q64Q		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	64	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CGCCGGTCTCCTGGTGCCTCA	0.607000													10	78					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141449223	141449223	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:141449223G>A	ENST00000389328.4	-	3	966	c.952C>T	c.(952-954)Cag>Tag	p.Q318*	TRAPPC9_ENST00000389327.3_Nonsense_Mutation_p.Q220*|TRAPPC9_ENST00000438773.2_Nonsense_Mutation_p.Q220*	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	220					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						AGGGAGTCCTGCAGCATCCCT	0.512000													22	107					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43006217	43006217	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43006217G>A	ENST00000587309.1	-	12	1752	c.1729C>T	c.(1729-1731)Cct>Tct	p.P577S	KIF18B_ENST00000593135.1_Missense_Mutation_p.P565S|KIF18B_ENST00000590129.1_Missense_Mutation_p.P586S|KIF18B_ENST00000438933.2_Missense_Mutation_p.P577S|KIF18B_ENST00000339151.4_Missense_Mutation_p.P577S	NM_001264573.1	NP_001251503.1			kinesin family member 18B											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				TGAGCCAGAGGTGCCCCCCTG	0.582000													8	11					0	0	1	0	0
TRIM61	391712	broad.mit.edu	37	4	165890967	165890967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:165890967C>T	ENST00000329314.5	-	3	800	c.188G>A	c.(187-189)aGg>aAg	p.R63K		NM_001012414.2	NP_001012414.1	Q5EBN2	TRI61_HUMAN	tripartite motif containing 61	63						intracellular	zinc ion binding			NS(1)|kidney(1)|liver(1)|skin(1)|upper_aerodigestive_tract(1)	5	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.155)		TATAAATTTCCTTTCTGGACA	0.453000													15	121					0	0	1	0	0
ANKRD50	57182	broad.mit.edu	37	4	125590235	125590235	+	Silent	SNP	G	G	A	rs138487103		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:125590235G>A	ENST00000504087.1	-	4	5234	c.4197C>T	c.(4195-4197)tcC>tcT	p.S1399S	ANKRD50_ENST00000515641.1_Silent_p.S1220S	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1399										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						CTGTCTCTGAGGAAGGGTATC	0.413000													28	68					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140414484	140414484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140414484G>A	ENST00000406427.1	-	11	1305	c.969C>T	c.(967-969)gcC>gcT	p.A323A	PNPLA7_ENST00000277531.4_Silent_p.A298A	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	298			R -> Q (in dbSNP:rs11137410).		lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CGAGAGGGATGGCCTGGCTCT	0.597000													75	161					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11215925	11215925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11215925C>T	ENST00000558518.1	+	4	530	c.343C>T	c.(343-345)Cgc>Tgc	p.R115C	LDLR_ENST00000545707.1_Intron|LDLR_ENST00000558013.1_Missense_Mutation_p.R115C|LDLR_ENST00000535915.1_Missense_Mutation_p.R74C|LDLR_ENST00000455727.2_Intron|LDLR_ENST00000557933.1_Missense_Mutation_p.R115C	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	115	LDL-receptor class A 3.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GGACGAGTTTCGCTGCCACGA	0.622000													66	147					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73964105	73964105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73964105C>T	ENST00000358602.4	-	26	4822	c.4706G>A	c.(4705-4707)aGg>aAg	p.R1569K	ANKRD17_ENST00000330838.6_Missense_Mutation_p.R1318K|ANKRD17_ENST00000509867.2_Missense_Mutation_p.R1456K	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	1569					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCTGTTTTTCCTCTTTGAACT	0.373000													43	106					0	0	1	0	0
TAGLN2	8407	broad.mit.edu	37	1	159890198	159890198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159890198G>A	ENST00000368097.4	-	2	412	c.102C>T	c.(100-102)atC>atT	p.I34I	TAGLN2_ENST00000320307.4_Silent_p.I34I|TAGLN2_ENST00000478033.1_5'UTR|TAGLN2_ENST00000368096.1_Silent_p.I55I	NM_001277223.1|NM_003564.1	NP_001264152.1|NP_003555.1	P37802	TAGL2_HUMAN	transgelin 2	34	CH.				muscle organ development	nuclear membrane|plasma membrane	protein binding			endometrium(1)|large_intestine(2)|lung(6)	9	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTGGGTGGTGATCCACTGGA	0.602000													26	78					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157959893	157959893	+	Missense_Mutation	SNP	C	C	T	rs144856548	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157959893C>T	ENST00000389413.3	-	6	743	c.640G>A	c.(640-642)Gag>Aag	p.E214K	PTPRN2_ENST00000409483.1_Missense_Mutation_p.E176K|PTPRN2_ENST00000404321.2_Missense_Mutation_p.E237K|PTPRN2_ENST00000389416.4_Missense_Mutation_p.E197K|PTPRN2_ENST00000389418.4_Missense_Mutation_p.E214K	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	214						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGGAGGTCCTCGCGGAGCTGG	0.647000													20	51					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179533882	179533882	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179533882G>A	ENST00000367615.4	-	2	389	c.321C>T	c.(319-321)ctC>ctT	p.L107L	NPHS2_ENST00000367616.4_Silent_p.L107L	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	107					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GCAGGGAAATGAGGACAAGAA	0.413000													22	53					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75051124	75051124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75051124C>T	ENST00000310715.3	-	20	2429	c.2309G>A	c.(2308-2310)cGg>cAg	p.R770Q	TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000355577.3_Missense_Mutation_p.R239Q|TTC18_ENST00000401621.2_Missense_Mutation_p.R770Q|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000394865.1_Missense_Mutation_p.R770Q	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	770							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CTGAAGCATCCGTGCCTGAAG	0.423000													57	112					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141779	29141779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29141779C>T	ENST00000377167.2	+	1	469	c.367C>T	c.(367-369)Cgt>Tgt	p.R123C		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						GTCATATGATCGTTATGTAGC	0.448000													94	255					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404029	20404029	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20404029C>T	ENST00000285600.4	+	1	263	c.204C>T	c.(202-204)ttC>ttT	p.F68F		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ATCTTTCTTTCATTGATATCT	0.388000													55	131					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130286134	130286134	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130286134G>A	ENST00000257359.6	-	4	1894	c.1188C>T	c.(1186-1188)ttC>ttT	p.F396F		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	396	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TCAGGTGGACGAACAGCGGTG	0.677000													4	9					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124756615	124756615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124756615C>T	ENST00000306534.3	-	16	3024	c.2539G>A	c.(2539-2541)Gga>Aga	p.G847R	ROBO4_ENST00000533054.1_Missense_Mutation_p.G702R|RP11-664I21.5_ENST00000524453.1_RNA	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	847					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCCACCCCTCCTCCAGTCCTG	0.662000													16	42					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91709262	91709262	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:91709262C>T	ENST00000359028.2	+	32	8076	c.7851C>T	c.(7849-7851)acC>acT	p.T2617T	AKAP9_ENST00000356239.3_Silent_p.T2605T|AKAP9_ENST00000358100.2_Silent_p.T2617T			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2617	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGCATTAACCTTGAGAATAT	0.289000			T	BRAF	papillary thyroid								43	80					0	0	1	0	0
SAP130	79595	broad.mit.edu	37	2	128753978	128753978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128753978G>A	ENST00000357702.5	-	11	1510	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F	SAP130_ENST00000259234.6_Missense_Mutation_p.S434F|SAP130_ENST00000259235.3_Missense_Mutation_p.S460F	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	460					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CCGATGTCCGGAGATGGGAAT	0.552000													9	104					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37514875	37514875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37514875C>T	ENST00000264741.5	+	3	600	c.344C>T	c.(343-345)aCc>aTc	p.T115I	ITGA9_ENST00000422441.1_Missense_Mutation_p.T115I	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	115					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TGCGGAAAGACCTGCCGGGAA	0.602000													11	48					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51160458	51160458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:51160458C>T	ENST00000414786.2	+	21	4382	c.4155C>T	c.(4153-4155)ttC>ttT	p.F1385F	SHANK3_ENST00000445220.2_Silent_p.F1401F|SHANK3_ENST00000262795.3_Silent_p.F1415F			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1415										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		ACACCTCCTTCGCTGACGGAC	0.632000													13	11					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110530483	110530483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110530483G>A	ENST00000378402.5	+	73	11881	c.11777G>A	c.(11776-11778)gGa>gAa	p.G3926E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3926					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGGTTAAAGGAACTATACCT	0.373000										HNSCC(38;0.096)			30	55					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34684295	34684295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34684295C>T	ENST00000488417.1	+	7	1850	c.1730C>T	c.(1729-1731)tCg>tTg	p.S577L	C1orf94_ENST00000373374.3_Missense_Mutation_p.S387L	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	387							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AGGTTCGGCTCGACATCCGGA	0.448000													22	85					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15734018	15734018	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15734018C>T	ENST00000441682.2	+	0	812							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CTTCCTCACTCCCTGTGGACG	0.562000													32	58					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111744784	111744784	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:111744784G>T	ENST00000261726.6	+	11	1072	c.918G>T	c.(916-918)aaG>aaT	p.K306N		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	306						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.K306K(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TGGCCTCCAAGGACAGGGAGA	0.642000													31	77					1.61788e-16	1.62657e-16	1	1	0
RBBP8NL	140893	broad.mit.edu	37	20	60991260	60991260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60991260C>T	ENST00000252998.1	-	6	502	c.346G>A	c.(346-348)Gag>Aag	p.E116K		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		TTCAAGGTCTCGTTCTCTTCC	0.637000													7	34					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49898437	49898437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49898437C>T	ENST00000477224.1	-	7	1055	c.577G>A	c.(577-579)Ggc>Agc	p.G193S	CAMKV_ENST00000488336.1_Missense_Mutation_p.G193S|CAMKV_ENST00000463537.1_Missense_Mutation_p.G193S|CAMKV_ENST00000296471.7_Intron|CAMKV_ENST00000467248.1_Missense_Mutation_p.G118S|CAMKV_ENST00000466940.1_Missense_Mutation_p.G150S			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	193	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CGCTGCCGGCCTACCACCTCT	0.572000													16	34					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168111061	168111061	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168111061C>T	ENST00000519560.1	-	32	4015	c.3596G>A	c.(3595-3597)gGa>gAa	p.G1199E	SLIT3_ENST00000332966.8_Missense_Mutation_p.G1206E|SLIT3_ENST00000404867.3_Missense_Mutation_p.G1199E	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1199	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCATTGTCTCCTTTGTAGAG	0.582000													14	64					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9483820	9483820	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:9483820C>T	ENST00000402466.1	+	11	1442	c.674C>T	c.(673-675)cCc>cTc	p.P225L	SETD5_ENST00000406341.1_Missense_Mutation_p.P323L|SETD5_ENST00000402198.1_Missense_Mutation_p.P323L|SETD5_ENST00000407969.1_Missense_Mutation_p.P342L|SETD5_ENST00000302463.6_Missense_Mutation_p.P225L			Q9C0A6	SETD5_HUMAN	SET domain containing 5	323										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGACCATACCCCTTTGTGCTC	0.418000													7	20					0	0	1	0	0
ADAM8	101	broad.mit.edu	37	10	135086808	135086808	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:135086808C>T	ENST00000445355.3	-	6	573	c.523G>A	c.(523-525)Ggc>Agc	p.G175S	ADAM8_ENST00000559180.1_Intron|ADAM8_ENST00000415217.3_Missense_Mutation_p.G175S|ADAM8_ENST00000485491.2_Missense_Mutation_p.G136S	NM_001109.4	NP_001100.3	B4DVM6	B4DVM6_HUMAN	ADAM metallopeptidase domain 8	136					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)	17		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		AGGAGGCTGCCCAGGCTGTCG	0.711000													3	5					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55151968	55151968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55151968G>A	ENST00000414150.2	+	15	2836	c.2558G>A	c.(2557-2559)aGc>aAc	p.S853N	MROH7_ENST00000409996.1_Missense_Mutation_p.S421N|MROH7_ENST00000339553.5_Missense_Mutation_p.S853N|MROH7_ENST00000454855.2_Missense_Mutation_p.S371N|MROH7_ENST00000545244.1_Missense_Mutation_p.S421N|MROH7_ENST00000395690.2_Missense_Mutation_p.S853N|MROH7_ENST00000421030.2_Missense_Mutation_p.S853N					maestro heat-like repeat family member 7																		TCCGTCAACAGCTGCATGGGC	0.652000													12	35					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35392492	35392492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35392492C>T	ENST00000311565.4	+	8	1363	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F	PPARD_ENST00000360694.3_Silent_p.F338F|PPARD_ENST00000337400.2_Silent_p.F338F|PPARD_ENST00000418635.2_Silent_p.F240F|PPARD_ENST00000448077.2_Silent_p.F299F|PPARD_ENST00000540939.1_Silent_p.F235F|PPARD_ENST00000444397.1_Silent_p.F338F	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	338	Ligand-binding.				apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	CTGTCAAGTTCAACGCCCTGG	0.547000													28	38					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48275352	48275352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48275352G>A	ENST00000225964.5	-	8	718	c.600C>T	c.(598-600)ggC>ggT	p.G200G		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	200	Triple-helical region.		G -> V (in OI1; patient diagnosed with OI1/OI4).		axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GACCTTGGAAGCCTTGGGGAC	0.493000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta				OREG0024560	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	37					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96612497	96612497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96612497G>A	ENST00000371321.3	+	9	1381	c.1299G>A	c.(1297-1299)cgG>cgA	p.R433R	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	433			R -> W (in allele CYP2C19*5A and allele CYP2C19*5B; loss of activity; dbSNP:rs56337013).		exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CAGGAAAACGGATTTGTGTGG	0.433000													32	94					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47717316	47717316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47717316G>A	ENST00000360380.3	-	18	3719	c.3356C>T	c.(3355-3357)aCc>aTc	p.T1119I	STIL_ENST00000371877.3_Missense_Mutation_p.T1120I|STIL_ENST00000396221.2_Missense_Mutation_p.T1102I|STIL_ENST00000337817.5_Missense_Mutation_p.T1119I|STIL_ENST00000243182.6_Missense_Mutation_p.T1119I			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	1119					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				ATATTTTTTGGTTGCAAATGA	0.373000													71	169					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29735010	29735010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29735010G>A	ENST00000357586.2	-	16	2318	c.2132C>T	c.(2131-2133)aCc>aTc	p.T711I	AP1B1_ENST00000317368.7_Missense_Mutation_p.T704I|AP1B1_ENST00000402502.1_Missense_Mutation_p.T704I|AP1B1_ENST00000432560.2_Missense_Mutation_p.T704I|AP1B1_ENST00000405198.1_Missense_Mutation_p.T711I|AP1B1_ENST00000356015.2_Missense_Mutation_p.T704I|AP1B1_ENST00000472057.1_5'UTR|AP1B1_ENST00000415447.1_Missense_Mutation_p.T704I	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	711	Pro-rich (stalk region).				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TCCTGACAGGGTGCCCACGCC	0.557000													64	145					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100510857	100510857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100510857G>A	ENST00000457717.1	+	5	707	c.451G>A	c.(451-453)Ggt>Agt	p.G151S	MTTP_ENST00000511045.1_Missense_Mutation_p.G178S|MTTP_ENST00000265517.5_Missense_Mutation_p.G151S	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	151	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TATCAAGAGAGGTCTGGCTAG	0.403000													13	55					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170236609	170236609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:170236609C>T	ENST00000518525.1	+	10	1334	c.870C>T	c.(868-870)atC>atT	p.I290I	GABRP_ENST00000519385.1_Intron|GABRP_ENST00000265294.4_Silent_p.I290I|GABRP_ENST00000519598.1_Silent_p.I290I			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	290						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CACTGATGATCGGGTCCCGCA	0.517000											OREG0017032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	178					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37407092	37407092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37407092G>A	ENST00000403892.3	-	2	1604	c.870C>T	c.(868-870)tcC>tcT	p.S290S	TST_ENST00000249042.3_Silent_p.S290S	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	290					cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						ACTTTCCCTGGGACACACGGC	0.602000													32	103					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24663358	24663358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:24663358C>T	ENST00000396475.2	+	3	371	c.72C>T	c.(70-72)ttC>ttT	p.F24F	MPP6_ENST00000222644.4_Silent_p.F24F|MPP6_ENST00000409761.1_Intron	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	24	L27 1.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						ACCTAATTTTCCTCAAGGGAA	0.348000													25	61					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215807692	215807692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:215807692C>T	ENST00000272895.7	-	50	7612	c.7393G>A	c.(7393-7395)Gga>Aga	p.G2465R	ABCA12_ENST00000389661.4_Missense_Mutation_p.G2147R|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2465	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGAAACTTTCCATTCACCATA	0.398000													24	50					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55719575	55719575	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55719575C>T	ENST00000373965.2	-	24	3454	c.3060G>A	c.(3058-3060)gaG>gaA	p.E1020E	PCDH15_ENST00000395445.1_Silent_p.E1020E|PCDH15_ENST00000409834.1_Silent_p.E624E|PCDH15_ENST00000437009.1_Silent_p.E942E|PCDH15_ENST00000361849.3_Silent_p.E1013E|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395433.1_Silent_p.E991E|PCDH15_ENST00000395432.2_Silent_p.E976E|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Silent_p.E1018E|PCDH15_ENST00000395430.1_Silent_p.E1013E|PCDH15_ENST00000320301.6_Silent_p.E1013E|PCDH15_ENST00000395438.1_Silent_p.E1013E	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1013	Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACATCACAGGCTCCCCATCAT	0.398000										HNSCC(58;0.16)			24	55					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118307871	118307871	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:118307871G>A	ENST00000369221.2	+	4	229		c.e4-1		PNLIP_ENST00000470562.1_Splice_Site	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGTCTAAACAGGAAGTTGCCG	0.388000													43	112					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112525239	112525239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112525239C>T	ENST00000369697.1	-	1	179	c.110G>A	c.(109-111)cGg>cAg	p.R37Q	KCND3_ENST00000315987.2_Missense_Mutation_p.R37Q|KCND3_ENST00000302127.4_Missense_Mutation_p.R37Q			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	37						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		CTCATCCTGCCGCTTGTTCTT	0.682000													11	53					0	0	1	0	0
MARC1	64757	broad.mit.edu	37	1	220970065	220970065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:220970065C>T	ENST00000366910.5	+	3	716	c.530C>T	c.(529-531)cCc>cTc	p.P177L	MARC1_ENST00000496110.1_3'UTR	NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	177							molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										AAGTCACAGCCCTACCGCCTG	0.607000													12	35					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500477	90500477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90500477C>T	ENST00000325643.5	+	4	1141	c.1075C>T	c.(1075-1077)Cct>Tct	p.P359S		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		ATTCATCCACCCTGACGTGCA	0.582000													6	67					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640386	57640386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57640386G>A	ENST00000254181.4	+	4	797	c.343G>A	c.(343-345)Gat>Aat	p.D115N	USP29_ENST00000598197.1_Missense_Mutation_p.D115N	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	115					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAATCTGATGATGATTGGAG	0.353000													20	69					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57843461	57843461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57843461G>A	ENST00000309668.2	+	2	842	c.715G>A	c.(715-717)Gac>Aac	p.D239N	INHBC_ENST00000550133.1_Intron	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	239					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						ACGAGGCATCGACTGCCAAGG	0.587000													15	26					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48667926	48667926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48667926C>T	ENST00000352832.5	+	10	2768	c.2396C>T	c.(2395-2397)cCc>cTc	p.P799L	CACNA1G_ENST00000514717.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000515765.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000510366.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000512389.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000513964.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000513689.2_Missense_Mutation_p.P799L|CACNA1G_ENST00000507609.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000505165.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000507336.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000507510.2_Missense_Mutation_p.P799L|CACNA1G_ENST00000442258.2_Missense_Mutation_p.P799L|CACNA1G_ENST00000514181.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000429973.2_Missense_Mutation_p.P799L|CACNA1G_ENST00000514079.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000515165.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000510115.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000503485.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000358244.5_Missense_Mutation_p.P799L|CACNA1G_ENST00000502264.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000416767.4_Missense_Mutation_p.P799L|CACNA1G_ENST00000359106.5_Missense_Mutation_p.P799L|CACNA1G_ENST00000354983.4_Missense_Mutation_p.P799L|CACNA1G_ENST00000507896.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000515411.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000360761.4_Missense_Mutation_p.P799L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	799					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTGTATGGTCCCTTTGGCTAC	0.517000													8	40					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8206855	8206855	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8206855G>A	ENST00000600128.1	-	7	1122	c.708C>T	c.(706-708)ttC>ttT	p.F236F	FBN3_ENST00000601739.1_Silent_p.F236F|FBN3_ENST00000270509.2_Silent_p.F236F			Q75N90	FBN3_HUMAN	fibrillin 3	236	TB 1.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TATTGGGGATGAAGCCGCGGC	0.632000													11	39					0	0	1	0	0
ZNF268	10795	broad.mit.edu	37	12	133780482	133780482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:133780482C>T	ENST00000536435.2	+	6	2540	c.2210C>T	c.(2209-2211)tCa>tTa	p.S737L	ZNF268_ENST00000537565.1_Missense_Mutation_p.S576L|ZNF268_ENST00000541009.2_3'UTR|ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000228289.5_Missense_Mutation_p.S737L|ZNF268_ENST00000542986.2_3'UTR	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	737						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AGTTTCAATTCACAACTCATT	0.408000													3	16					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36358229	36358229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36358229G>A	ENST00000373204.4	+	3	494	c.281G>A	c.(280-282)gGa>gAa	p.G94E	AGO1_ENST00000373206.1_Missense_Mutation_p.G19E	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GTGTATGATGGAAAGAAGAAC	0.527000													32	60					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167060643	167060643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167060643C>T	ENST00000375387.4	-	26	4939	c.4599G>A	c.(4597-4599)atG>atA	p.M1533I	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Missense_Mutation_p.M1532I|SCN9A_ENST00000409672.1_Missense_Mutation_p.M1521I|SCN9A_ENST00000303354.6_Missense_Mutation_p.M1533I			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1532						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTTCTACCATCATGGTTACCA	0.343000													12	53					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23391470	23391470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23391470G>A	ENST00000343070.2	+	12	1698	c.1522G>A	c.(1522-1524)Gaa>Aaa	p.E508K	SCNN1B_ENST00000307331.5_Missense_Mutation_p.E553K|SCNN1B_ENST00000568085.1_Missense_Mutation_p.E472K|SCNN1B_ENST00000568923.1_Missense_Mutation_p.E481K	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	508					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TCGCACCATTGAAGAATCAGC	0.542000													19	81					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585375	82585375	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82585375C>T	ENST00000423517.2	-	5	5231	c.4894G>A	c.(4894-4896)Gaa>Aaa	p.E1632K	PCLO_ENST00000333891.8_Missense_Mutation_p.E1632K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1563					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.E1632K(2)|p.E1563K(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCATCGTCTTCATCATGCCAT	0.428000													83	200					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124459274	124459274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124459274C>T	ENST00000329446.4	-	1	64	c.33G>A	c.(31-33)agG>agA	p.R11R		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	11										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				GTTTTTCAATCCTCTGACAGT	0.428000													22	64					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	134980930	134980930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134980930C>T	ENST00000304613.3	+	2	169	c.148C>T	c.(148-150)Ctc>Ttc	p.L50F	KNDC1_ENST00000368572.2_Missense_Mutation_p.L50F|KNDC1_ENST00000530127.1_3'UTR|KNDC1_ENST00000368571.2_5'UTR			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	50	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGACCGCGGCCTCAGCGAGCA	0.711000													4	10					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46704372	46704372	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46704372C>T	ENST00000454366.1	+	4	506	c.294C>T	c.(292-294)ttC>ttT	p.F98F		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	79					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		GGGAGAAGTTCGTGGAGGTGT	0.567000													55	151					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073561	9073561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9073561C>T	ENST00000397910.4	-	3	14088	c.13885G>A	c.(13885-13887)Gct>Act	p.A4629T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4631	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCAGTAATAGCCCCCACAGAC	0.458000													18	62					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27296616	27296616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27296616C>T	ENST00000397501.1	+	24	2520	c.1712C>T	c.(1711-1713)tCc>tTc	p.S571F	PTK2B_ENST00000397497.4_Missense_Mutation_p.S317F|PTK2B_ENST00000544172.1_Missense_Mutation_p.S571F|PTK2B_ENST00000338238.4_Missense_Mutation_p.S571F|PTK2B_ENST00000420218.2_Missense_Mutation_p.S571F|PTK2B_ENST00000346049.5_Missense_Mutation_p.S571F|PTK2B_ENST00000517339.1_Missense_Mutation_p.S571F	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	571	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TTTGGTCTTTCCCGGTACATT	0.557000													29	78					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	17990868	17990868	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17990868G>A	ENST00000262608.8	+	7	771	c.771G>A	c.(769-771)aaG>aaA	p.K257K	CECR2_ENST00000342247.5_Intron|CECR2_ENST00000400573.4_Silent_p.K276K|CECR2_ENST00000400585.2_Silent_p.K135K	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	298					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		AGCGCACAAAGGCAGAGTTGC	0.493000													14	174					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73615396	73615396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73615396C>T	ENST00000261917.3	-	8	4031	c.3038G>A	c.(3037-3039)gGg>gAg	p.G1013E		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	1013	Pro-rich.				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		AGGGGAAGCCCCCCCAGAGGC	0.711000													5	9					0	0	1	0	0
FAM78B	149297	broad.mit.edu	37	1	166135292	166135292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:166135292G>A	ENST00000338353.3	-	2	783	c.194C>T	c.(193-195)aCc>aTc	p.T65I	FAM78B_ENST00000354422.3_Missense_Mutation_p.T65I			Q5VT40	FA78B_HUMAN	family with sequence similarity 78, member B	65										central_nervous_system(1)|endometrium(5)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					CACCACCCAGGTCTCGTGGCG	0.652000													12	25					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73056937	73056937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:73056937G>A	ENST00000261180.4	+	19	3133	c.3037G>A	c.(3037-3039)Gag>Aag	p.E1013K		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1013					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding	p.E1013Q(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTACCAAGACGAGCTTTTCCA	0.393000													12	36					0	0	1	0	0
DCN	1634	broad.mit.edu	37	12	91572281	91572281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91572281C>T	ENST00000551354.1	-	2	253	c.49G>A	c.(49-51)Gga>Aga	p.G17R	DCN_ENST00000546370.1_Missense_Mutation_p.G17R|DCN_ENST00000052754.5_Missense_Mutation_p.G17R|DCN_ENST00000550099.1_Missense_Mutation_p.G17R|DCN_ENST00000420120.2_Missense_Mutation_p.G17R|DCN_ENST00000228329.5_Missense_Mutation_p.G17R|DCN_ENST00000456569.2_Missense_Mutation_p.G17R|DCN_ENST00000441303.2_Missense_Mutation_p.G17R|DCN_ENST00000547568.2_Missense_Mutation_p.G17R|DCN_ENST00000552962.1_Missense_Mutation_p.G17R|DCN_ENST00000393155.1_Missense_Mutation_p.G17R|DCN_ENST00000425043.1_Missense_Mutation_p.G17R|DCN_ENST00000303320.3_Missense_Mutation_p.G17R|DCN_ENST00000546745.1_Missense_Mutation_p.G17R			P07585	PGS2_HUMAN	decorin	17					organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						TGAAACGGTCCAGCCCAGGAA	0.473000											OREG0022021	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	58					0	0	1	0	0
C15orf32	145858	broad.mit.edu	37	15	93015479	93015479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93015479C>T	ENST00000333334.2	+	1	596	c.101C>T	c.(100-102)aCt>aTt	p.T34I	C15orf32_ENST00000556865.1_Missense_Mutation_p.T34I	NM_153040.2	NP_694585.1	Q32M92	CO032_HUMAN	chromosome 15 open reading frame 32	34										endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	12	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			AACACCAAGACTTCCCCAAGA	0.537000													74	93					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121326189	121326189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:121326189G>A	ENST00000297848.3	+	38	4744	c.4474G>A	c.(4474-4476)Ggt>Agt	p.G1492S	COL14A1_ENST00000309791.4_Missense_Mutation_p.G1492S|COL14A1_ENST00000247781.3_Missense_Mutation_p.G1397S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1492	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGCCCTCGGGGTGAAATTGG	0.473000													39	157					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175598335	175598335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175598335G>A	ENST00000274093.3	-	7	1323	c.821C>T	c.(820-822)tCa>tTa	p.S274L	GLRA3_ENST00000340217.5_Missense_Mutation_p.S274L	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	274					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GATCCAGAATGAAACCCAGGA	0.478000													11	33					0	0	1	0	0
AKR7L	246181	broad.mit.edu	37	1	19595801	19595801	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19595801G>A	ENST00000420396.2	-	0	507				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						GAGTCCCAAAGAAGCGGCCCA	0.592000													26	84					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233322985	233322985	+	Silent	SNP	G	G	A	rs143128875		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233322985G>A	ENST00000295463.3	+	9	1127	c.1050G>A	c.(1048-1050)gcG>gcA	p.A350A		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	350					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCACTGAGGCGGTCATGTTCG	0.627000													23	51					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55368262	55368262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55368262G>A	ENST00000449076.1	-	2	217	c.85C>T	c.(85-87)Cta>Tta	p.L29L	TESPA1_ENST00000316577.8_Silent_p.L29L	NM_001136030.2	NP_001129502.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	29																	TCCTCTTCTAGGACCTGGGTC	0.612000													6	11					0	0	1	0	0
ADORA1	134	broad.mit.edu	37	1	203134472	203134472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203134472C>T	ENST00000367236.4	+	3	1346	c.425C>T	c.(424-426)cCt>cTt	p.P142L	ADORA1_ENST00000309502.3_Missense_Mutation_p.P142L|ADORA1_ENST00000472535.1_3'UTR|ADORA1_ENST00000337894.4_Missense_Mutation_p.P142L|ADORA1_ENST00000367235.1_3'UTR	NM_001048230.1	NP_001041695.1	P30542	AA1R_HUMAN	adenosine A1 receptor	142					induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(9)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GGACTGACCCCTATGTTTGGC	0.647000													23	31					0	0	1	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209950792	209950792	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209950792G>A	ENST00000367024.1	+	12	1665	c.1149G>A	c.(1147-1149)ggG>ggA	p.G383G	TRAF3IP3_ENST00000477431.1_Silent_p.G119G|TRAF3IP3_ENST00000367026.3_Silent_p.G363G|TRAF3IP3_ENST00000400959.3_Silent_p.G363G|TRAF3IP3_ENST00000367023.1_Silent_p.G119G|TRAF3IP3_ENST00000367025.3_Silent_p.G383G|TRAF3IP3_ENST00000010338.4_Silent_p.G363G			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	383						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		GCCTGCAAGGGGACAGAGACC	0.522000													14	48					0	0	1	0	0
ZBED6CL	113763	broad.mit.edu	37	7	150028044	150028044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150028044C>T	ENST00000343855.4	+	1	1107	c.551C>T	c.(550-552)tCg>tTg	p.S184L	LRRC61_ENST00000493307.1_Intron|LRRC61_ENST00000359623.4_Intron|LRRC61_ENST00000323078.7_Intron	NM_138434.2	NP_612443.1			ZBED6 C-terminal like																		AGCGGGGGCTCGCTGTCCACC	0.622000													12	19					0	0	1	0	0
HELQ	113510	broad.mit.edu	37	4	84337894	84337894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:84337894G>A	ENST00000295488.3	-	17	3350	c.3188C>T	c.(3187-3189)tCa>tTa	p.S1063L	HELQ_ENST00000510985.1_Missense_Mutation_p.S996L	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	1063							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						CTTTGCTGATGAAACAATTTG	0.343000								Other identified genes with known or suspected DNA repair function					16	247					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533045	169533045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169533045G>A	ENST00000449804.2	+	1	129	c.84G>A	c.(82-84)atG>atA	p.M28I	FOXI1_ENST00000306268.6_Missense_Mutation_p.M28I	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	28	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCCGAGATGAACCTCTACT	0.697000									Pendred syndrome				16	45					0	0	1	0	0
BOD1L2	284257	broad.mit.edu	37	18	54814920	54814920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:54814920C>T	ENST00000585477.1	+	1	628	c.377C>T	c.(376-378)cCa>cTa	p.P126L		NM_001257964.1	NP_001244893.1			biorientation of chromosomes in cell division 1-like 2																		GTGGTGGATCCAAAACTAAAC	0.502000													20	50					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43930230	43930230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43930230C>T	ENST00000261488.6	-	8	1225	c.648G>A	c.(646-648)gtG>gtA	p.V216V	ENOX1_ENST00000540032.1_Silent_p.V29V|ENOX1_ENST00000412891.1_Silent_p.V216V	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	216	RRM.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GGGCAAAGTCCACATGAAGGC	0.547000													17	59					0	0	1	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208842195	208842195	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:208842195G>T	ENST00000457206.1	-	3	1153	c.726C>A	c.(724-726)ttC>ttA	p.F242L	PLEKHM3_ENST00000389247.4_Missense_Mutation_p.F242L|PLEKHM3_ENST00000427836.2_Missense_Mutation_p.F242L			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	242	PH 1.				intracellular signal transduction		metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CGAGGCTGTAGAAGTATAAGT	0.448000													41	135					2.37825e-27	2.394e-27	1	1	0
ELFN2	114794	broad.mit.edu	37	22	37769836	37769836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37769836G>A	ENST00000402918.1	-	3	2524	c.1739C>T	c.(1738-1740)tCc>tTc	p.S580F	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Missense_Mutation_p.S580F	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	580						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					TGCAGGGAGGGACTGGCACTC	0.652000													11	26					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206320265	206320265	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206320265C>T	ENST00000361052.3	+	4	526	c.408C>T	c.(406-408)tcC>tcT	p.S136S	CTSE_ENST00000358184.2_Silent_p.S136S|CTSE_ENST00000360218.2_Silent_p.S136S|CTSE_ENST00000468617.1_3'UTR|CTSE_ENST00000432969.2_Silent_p.S61S			P14091	CATE_HUMAN	cathepsin E	136					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			AATCTTTCTCCATTCAGTATG	0.517000													26	65					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101086823	101086823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:101086823G>A	ENST00000394095.2	-	8	882	c.829C>T	c.(829-831)Ctc>Ttc	p.L277F	SENP7_ENST00000314261.7_Missense_Mutation_p.L211F|SENP7_ENST00000358203.3_Missense_Mutation_p.L113F|SENP7_ENST00000394091.1_Missense_Mutation_p.L113F|SENP7_ENST00000348610.3_Missense_Mutation_p.L244F|SENP7_ENST00000394094.2_Missense_Mutation_p.L212F	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	277					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TCCTGTTCGAGATGATCACAA	0.338000													28	88					0	0	1	0	0
STOX1	219736	broad.mit.edu	37	10	70644918	70644918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70644918C>T	ENST00000298596.6	+	3	1449	c.1366C>T	c.(1366-1368)Cct>Tct	p.P456S	STOX1_ENST00000399165.4_Intron|STOX1_ENST00000399162.2_Intron|STOX1_ENST00000421961.2_Missense_Mutation_p.P346S|STOX1_ENST00000399169.4_Missense_Mutation_p.P456S	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	456						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						CCCCAAGCTCCCTGCTACACA	0.478000													50	96					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110681737	110681737	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:110681737C>T	ENST00000394634.2	-	5	921	c.714G>A	c.(712-714)atG>atA	p.M238I	CFI_ENST00000512148.1_Missense_Mutation_p.M238I|CFI_ENST00000394635.3_Missense_Mutation_p.M238I	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	238	LDL-receptor class A 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CACAGGCTTTCATCTGAGAAA	0.348000													30	68					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13659684	13659684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13659684G>A	ENST00000404922.3	+	6	1957	c.1838G>A	c.(1837-1839)gGa>gAa	p.G613E	FBLN2_ENST00000535798.1_Missense_Mutation_p.G639E|FBLN2_ENST00000492059.1_Missense_Mutation_p.G613E|FBLN2_ENST00000295760.7_Missense_Mutation_p.G613E	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	613	EGF-like 1; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CTCCTCCCGGGAGAGCTGTGC	0.632000													20	103					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116931709	116931709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116931709G>A	ENST00000356083.3	+	3	2265	c.1874G>A	c.(1873-1875)gGg>gAg	p.G625E		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	625	Collagen-like 1.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CTGCTGATGGGGCCTCCGGGA	0.632000													11	68					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130286073	130286073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130286073G>A	ENST00000373312.3	-	5	687	c.474C>T	c.(472-474)ttC>ttT	p.F158F	FAM129B_ENST00000373314.3_Silent_p.F145F|FAM129B_ENST00000468379.1_Intron	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	158	PH.						protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						GGATGAGCGGGAACTGTGTGG	0.602000											OREG0019507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	92					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4797517	4797517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4797517G>A	ENST00000299320.5	+	9	1932	c.1454G>A	c.(1453-1455)gGg>gAg	p.G485E	C16orf71_ENST00000590191.1_Missense_Mutation_p.G502E|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	485										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						TGTGCCAAGGGGCAGAGCGCC	0.672000													11	34					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51900495	51900495	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51900495C>T	ENST00000371117.3	-	28	3397	c.3122G>A	c.(3121-3123)gGc>gAc	p.G1041D	PKHD1_ENST00000340994.4_Missense_Mutation_p.G1041D	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1041	IPT/TIG 5.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CAAACTAGAGCCTCGGATGGT	0.428000													26	52					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31483684	31483684	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31483684T>A	ENST00000322054.5	+	4	1096	c.811T>A	c.(811-813)Ttt>Att	p.F271I	EHD3_ENST00000541626.1_Intron	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	271					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					CCGGAAGCTCTTTGAGGCTGA	0.592000													28	107					0	0	1	0	0
LOC401127	401127	broad.mit.edu	37	4	39482951	39482951	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39482951G>A	ENST00000513652.1	+	0	958																											AACTTCAGACGAAAGAGATTG	0.438000													17	62					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450377	158450377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158450377C>T	ENST00000368152.1	+	1	710	c.710C>T	c.(709-711)tCt>tTt	p.S237F	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					ATCTGTGTTTCTTATCTCTGC	0.433000													29	112					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43788174	43788174	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43788174C>T	ENST00000261488.6	-	17	2461	c.1884G>A	c.(1882-1884)ctG>ctA	p.L628L	ENOX1_ENST00000412891.1_Silent_p.L628L	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	628					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		ATCTTTTTTCCAGCGTGGCTC	0.448000													28	88					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39883959	39883959	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39883959G>A	ENST00000341184.6	+	2	822	c.607G>A	c.(607-609)Gag>Aag	p.E203K		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	203					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GGTGCCCAGGGAGGTGCCGCG	0.677000													7	18					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919074	12919074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12919074G>A	ENST00000240189.2	+	2	297	c.210G>A	c.(208-210)atG>atA	p.M70I		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	70										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TATCGCTGATGAAGACGCTTC	0.567000													87	295					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39202124	39202124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39202124G>A	ENST00000351578.6	-	2	1129	c.939C>T	c.(937-939)ttC>ttT	p.F313F	FYB_ENST00000540520.1_Silent_p.F323F|FYB_ENST00000515010.1_Silent_p.F313F|FYB_ENST00000512982.1_Silent_p.F313F|FYB_ENST00000505428.1_Silent_p.F313F	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	313					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			GGGCCTTAGGGAACCTGGCAG	0.498000													27	67					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84523312	84523312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84523312G>A	ENST00000360700.4	+	8	1953	c.1067G>A	c.(1066-1068)aGa>aAa	p.R356K	ZNF711_ENST00000373165.3_Missense_Mutation_p.R310K|ZNF711_ENST00000276123.3_Missense_Mutation_p.R310K|ZNF711_ENST00000395402.1_Intron|ZNF711_ENST00000542798.1_Missense_Mutation_p.R152K			Q9Y462	ZN711_HUMAN	zinc finger protein 711	310					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GATGAAAGAAGAGTTTCCCGA	0.303000													5	13					0	0	1	0	0
FOXC2	2303	broad.mit.edu	37	16	86601587	86601587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:86601587G>A	ENST00000320354.4	+	1	731	c.646G>A	c.(646-648)Gag>Aag	p.E216K		NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	216					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						GATCAAGAGCGAGGCGGCGTC	0.756000									Late-onset Hereditary Lymphedema				8	12					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111304210	111304210	+	Silent	SNP	G	G	A	rs139540088	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111304210G>A	ENST00000352690.4	+	5	1032	c.792G>A	c.(790-792)acG>acA	p.T264T	CD96_ENST00000283285.5_Silent_p.T280T|CD96_ENST00000438817.2_Silent_p.T264T	NM_005816.4	NP_005807.1	P40200	TACT_HUMAN	CD96 molecule	280					cell adhesion|immune response|regulation of immune response	integral to plasma membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(4)|liver(2)|lung(14)|skin(5)	35						ATAACTCCACGGATGTCTTGG	0.408000									Opitz Trigonocephaly syndrome				20	49					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914910	46914910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46914910C>T	ENST00000307522.3	-	1	1931	c.1158G>A	c.(1156-1158)gaG>gaA	p.E386E		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	386						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		TATCTGCAGCCTCTTCCCTGT	0.577000													20	237					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142186765	142186765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142186765G>A	ENST00000519811.1	+	15	2681	c.2611G>A	c.(2611-2613)Gaa>Aaa	p.E871K	DENND3_ENST00000424248.1_Missense_Mutation_p.E739K|DENND3_ENST00000262585.2_Missense_Mutation_p.E791K			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	791										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCCAAGAAAGAAGTCTTCGA	0.488000													10	89					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815653	158815653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158815653G>A	ENST00000368141.4	+	5	1108	c.847G>A	c.(847-849)Gca>Aca	p.A283T		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	283	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					AATAAAGGAAGCATCATCTGT	0.343000													30	65					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98528268	98528268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98528268C>T	ENST00000359863.4	+	25	3615	c.3406C>T	c.(3406-3408)Ccc>Tcc	p.P1136S	TRRAP_ENST00000355540.3_Missense_Mutation_p.P1136S|TRRAP_ENST00000446306.3_Missense_Mutation_p.P1135S	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1136					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTGCCAGCTGCCCCTGTTTTC	0.483000													97	210					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59410955	59410955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:59410955G>A	ENST00000301645.3	-	2	291	c.154C>T	c.(154-156)Cct>Tct	p.P52S		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	52					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AACTCAAGAGGATTGGCACCA	0.418000									Neonatal Giant Cell Hepatitis				57	148					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72857095	72857095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72857095G>A	ENST00000339594.4	-	18	4392	c.4054C>T	c.(4054-4056)Ctc>Ttc	p.L1352F	BAZ1B_ENST00000404251.1_Missense_Mutation_p.L1352F	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1352					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				ATCTTGTGGAGGATCTCTTCA	0.532000													21	58					0	0	1	0	0
KRT35	3886	broad.mit.edu	37	17	39637034	39637034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39637034C>T	ENST00000246639.2	-	1	358	c.226G>A	c.(226-228)Gac>Aac	p.D76N	KRT35_ENST00000393989.1_Missense_Mutation_p.D106N			Q92764	KRT35_HUMAN	keratin 35	106	Head.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.000286)				GCCAGGCGGTCGTTCAGGGAT	0.637000													50	48					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47650116	47650116	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47650116C>T	ENST00000398742.2	+	5	1666	c.1617C>T	c.(1615-1617)ttC>ttT	p.F539F	GPR111_ENST00000507065.1_Silent_p.F539F|GPR111_ENST00000296862.1_Silent_p.F607F			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	607					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TCCTGGCCTTCGTGATCCCAG	0.537000													12	36					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100155313	100155313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:100155313C>T	ENST00000263174.4	+	7	1872	c.1497C>T	c.(1495-1497)ccC>ccT	p.P499P	PALMD_ENST00000605497.1_Silent_p.P499P	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	499					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		ATAAATCCCCCCACAAAAATT	0.463000													23	59					0	0	1	0	0
AGAP7	653268	broad.mit.edu	37	10	51465237	51465237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:51465237C>T	ENST00000374095.5	-	7	1344	c.1219G>A	c.(1219-1221)Gag>Aag	p.E407K		NM_001077685.1	NP_001071153.1	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	407	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	11						GCATCCCGCTCCTCATATGTC	0.512000													48	145					0	0	1	0	0
OR10A2	341276	broad.mit.edu	37	11	6891435	6891435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6891435C>T	ENST00000307322.4	+	1	512	c.450C>T	c.(448-450)ctC>ctT	p.L150L		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCACATGGCTCTTCAGTTTTC	0.532000													62	153					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89999523	89999523	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89999523C>T	ENST00000405460.2	+	35	8293	c.8197C>T	c.(8197-8199)Cga>Tga	p.R2733*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2733					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTCCCTGGTCGAGGAAATGT	0.318000													9	21					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21793123	21793123	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21793123A>C	ENST00000206660.6	+	14	2109	c.2109A>C	c.(2107-2109)atA>atC	p.I703I	RPGRIP1_ENST00000557771.1_Silent_p.I665I|RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000307974.4_Silent_p.I62I|RPGRIP1_ENST00000400017.2_Silent_p.I703I|RPGRIP1_ENST00000553500.1_Intron|RPGRIP1_ENST00000382933.4_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	703					response to stimulus|visual perception	cilium		p.I703I(1)|p.I319I(1)		breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GGCTTGACATACACCAGGCCA	0.532000													50	128					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3267122	3267122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3267122C>T	ENST00000520002.1	-	14	2125	c.1570G>A	c.(1570-1572)Gaa>Aaa	p.E524K	CSMD1_ENST00000542608.1_Missense_Mutation_p.E523K|CSMD1_ENST00000400186.3_Missense_Mutation_p.E524K|CSMD1_ENST00000602557.1_Missense_Mutation_p.E524K|CSMD1_ENST00000537824.1_Missense_Mutation_p.E523K|CSMD1_ENST00000602723.1_Missense_Mutation_p.E524K|CSMD1_ENST00000539096.1_Missense_Mutation_p.E523K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	524						integral to membrane		p.E252K(1)|p.E523K(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTCCCTTTTCAATTTCTGAA	0.443000													4	13					0	0	1	0	0
SRRM1	10250	broad.mit.edu	37	1	24995781	24995781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24995781C>T	ENST00000323848.9	+	14	2222	c.1907C>T	c.(1906-1908)tCc>tTc	p.S636F	SRRM1_ENST00000374389.4_Missense_Mutation_p.S645F|SRRM1_ENST00000479034.1_3'UTR|SRRM1_ENST00000447431.2_Missense_Mutation_p.S648F	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	636	Arg-rich.|Necessary for speckles and matrix localization.|Pro-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CGGCGGGTCTCCCATTCTCCA	0.532000													43	112					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20702496	20702496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20702496C>T	ENST00000307493.4	-	1	82	c.15G>A	c.(13-15)atG>atA	p.M5I	ACSM1_ENST00000520010.1_Missense_Mutation_p.M5I|ACSM1_ENST00000219151.4_5'UTR	NM_052956.2	NP_443188.2	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	5					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TCCGGAACCTCATTAGCCACT	0.527000													46	121					0	0	1	0	0
LANCL2	55915	broad.mit.edu	37	7	55467766	55467766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55467766C>T	ENST00000254770.2	+	4	1225	c.647C>T	c.(646-648)cCa>cTa	p.P216L	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	216					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			GAGATAGGTCCAGGCACCGTG	0.463000													39	116					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237944	56237944	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56237944G>A	ENST00000312240.2	-	1	70	c.30C>T	c.(28-30)ttC>ttT	p.F10F		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					CCAAAAGAATGAACTCTGTCA	0.363000													18	67					0	0	1	0	0
IGHV3-15	28448	broad.mit.edu	37	14	106610738	106610738	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106610738G>A	ENST00000390603.2	-	0	114																											TTTTAAAATAGCAGCAAGGAA	0.448000													43	158					0	0	1	0	0
OR52E2	119678	broad.mit.edu	37	11	5080723	5080723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5080723G>A	ENST00000321522.2	-	1	134	c.135C>T	c.(133-135)ttC>ttT	p.F45F		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTAGAATAGTGAAGTTCCCTA	0.507000													11	57					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760574	19760574	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19760574G>A	ENST00000357324.6	-	18	2537	c.2511C>T	c.(2509-2511)ttC>ttT	p.F837F	ATP13A1_ENST00000291503.5_Silent_p.F719F	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	837					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CCACACGGGCGAACACCTGCA	0.672000													10	63					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29430209	29430209	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29430209G>A	ENST00000377136.1	+	4	1128	c.663G>A	c.(661-663)caG>caA	p.Q221Q	OR2H1_ENST00000377133.1_Silent_p.Q221Q|OR2H1_ENST00000442615.1_Silent_p.Q221Q|OR2H1_ENST00000396792.2_Silent_p.Q221Q|OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377132.1_Silent_p.Q221Q			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						CCACTGCCCAGGCAGTGCTGA	0.532000													62	171					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21145707	21145707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21145707G>A	ENST00000261383.3	-	7	954	c.955C>T	c.(955-957)Cct>Tct	p.P319S	DNAH3_ENST00000415178.1_Missense_Mutation_p.P319S	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	319	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACTCTTTGAGGAAACAAGCGG	0.527000													34	127					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33586667	33586667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33586667G>A	ENST00000262873.7	+	33	4357	c.4265G>A	c.(4264-4266)aGc>aAc	p.S1422N		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1380						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CAGTGGAGGAGCAAGTACGAA	0.627000													12	46					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3889577	3889577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3889577C>T	ENST00000520002.1	-	4	1015	c.460G>A	c.(460-462)Gga>Aga	p.G154R	CSMD1_ENST00000542608.1_Missense_Mutation_p.G154R|CSMD1_ENST00000400186.3_Missense_Mutation_p.G154R|CSMD1_ENST00000602557.1_Missense_Mutation_p.G154R|CSMD1_ENST00000537824.1_Missense_Mutation_p.G154R|CSMD1_ENST00000602723.1_Missense_Mutation_p.G154R|CSMD1_ENST00000539096.1_Missense_Mutation_p.G154R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	154	Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCAGAACTCCTTTCAGGATT	0.448000													16	45					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62189529	62189529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:62189529G>A	ENST00000474889.1	+	12	2437	c.2060G>A	c.(2059-2061)gGg>gAg	p.G687E	PTPRG_ENST00000295874.10_Missense_Mutation_p.G687E	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	687					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CAGTATGCAGGGAGTGATCCC	0.587000													22	58					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86591475	86591475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86591475C>T	ENST00000370571.2	-	3	910	c.544G>A	c.(544-546)Gga>Aga	p.G182R	COL24A1_ENST00000436319.1_Missense_Mutation_p.G182R	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	182	Laminin G-like.|TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TATTTCTTTCCACACTCAACA	0.343000													6	36					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75898440	75898440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:75898440G>A	ENST00000377636.3	-	11	2477	c.2131C>T	c.(2131-2133)Ccc>Tcc	p.P711S	TBC1D4_ENST00000431480.2_Missense_Mutation_p.P711S|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000377625.2_Intron	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	711	Ser-rich.					cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AGGAAAGAGGGGGCAGTGAAG	0.453000													23	76					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67915583	67915583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67915583C>T	ENST00000358933.5	+	22	3078	c.2839C>T	c.(2839-2841)Cct>Tct	p.P947S		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	947					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		GGCAGAGCCCCCTGAGGACTG	0.607000													14	40					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131521621	131521621	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131521621G>A	ENST00000423981.1	+	2	2086	c.1976G>A	c.(1975-1977)aGg>aAg	p.R659K	AMER3_ENST00000321420.4_Missense_Mutation_p.R659K	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GGCCCCTGGAGGCCAGGTCAC	0.632000													5	13					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30898673	30898673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30898673C>T	ENST00000375712.3	+	2	1260	c.1093C>T	c.(1093-1095)Ctc>Ttc	p.L365F	KIF3B_ENST00000418717.2_Missense_Mutation_p.L53F	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	365					anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GATTGCTCGGCTCAAGGCCCA	0.557000													9	76					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364688	5364688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5364688G>A	ENST00000300773.2	-	1	121	c.67C>T	c.(67-69)Cac>Tac	p.H23Y	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAATCCAGTGATGAGCTTCC	0.433000													12	43					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49867482	49867482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49867482G>A	ENST00000331456.2	-	12	1170	c.1057C>T	c.(1057-1059)Ccc>Tcc	p.P353S	TRAIP_ENST00000469027.1_Missense_Mutation_p.P198S	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	353	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ATCTTCTTGGGGACATCCTGA	0.537000													35	111					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28119655	28119655	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28119655C>T	ENST00000330236.6	+	4	776	c.592C>T	c.(592-594)Cag>Tag	p.Q198*	ZKSCAN8_ENST00000457389.2_Nonsense_Mutation_p.Q198*	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		TACTCGTTCCCAGAAAGGAAG	0.527000													37	76					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17015315	17015315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17015315C>T	ENST00000443236.1	-	31	4247	c.4216G>A	c.(4216-4218)Ggc>Agc	p.G1406S		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1359						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						AAGAATGTGCCCTTGTCCACG	0.582000													33	74					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122759828	122759828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:122759828G>A	ENST00000245838.8	-	25	3023	c.2992C>T	c.(2992-2994)Cgt>Tgt	p.R998C	THOC2_ENST00000355725.4_Missense_Mutation_p.R998C|THOC2_ENST00000491737.1_Missense_Mutation_p.R883C	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	998					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						TCAACAAAACGAGCACAGTAA	0.323000													30	33					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127340602	127340602	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127340602C>T	ENST00000265056.7	+	16	2945	c.2701C>T	c.(2701-2703)Ctg>Ttg	p.L901L	MCM2_ENST00000468414.1_3'UTR	NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	901					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GAAAATGATCCTGCAGCAGTT	0.493000													18	49					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683778	159683778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159683778G>A	ENST00000255030.5	-	2	315	c.212C>T	c.(211-213)tCg>tTg	p.S71L	CRP_ENST00000368110.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000437342.1_Intron|CRP_ENST00000368111.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	71	Pentaxin.			YSIFSYATKRQDNEIL -> TVFSRMPPRDKTMRFF (in Ref. 4; CAA39671).	acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	GGTGGCATACGAGAAAATACT	0.448000													27	72					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94145923	94145923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94145923G>A	ENST00000282020.4	+	7	1380	c.1122G>A	c.(1120-1122)aaG>aaA	p.K374K	GRID2_ENST00000510992.1_Silent_p.K279K	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	374					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGACCATCAAGAAGGTAACTT	0.383000													16	41					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423271	56423271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56423271G>A	ENST00000588751.1	-	5	1936	c.1912C>T	c.(1912-1914)Ctt>Ttt	p.L638F	NLRP13_ENST00000342929.3_Missense_Mutation_p.L638F			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	638							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAGTGAAAAAGTCGTAGAATG	0.418000													32	81					0	0	1	0	0
FTMT	94033	broad.mit.edu	37	5	121188184	121188184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:121188184G>A	ENST00000321339.1	+	1	535	c.526G>A	c.(526-528)Gaa>Aaa	p.E176K		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	176	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GTCGTTGCTGGAATTGCACGC	0.507000													19	151					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	132110631	132110631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:132110631G>A	ENST00000404460.1	+	7	516	c.462G>A	c.(460-462)acG>acA	p.T154T	PLEKHB2_ENST00000303908.3_Silent_p.T154T			Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	0						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		ACACCACCACGAGTGCAAAAA	0.453000													9	41					0	0	1	0	0
BLVRA	644	broad.mit.edu	37	7	43846778	43846778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43846778C>T	ENST00000402924.1	+	9	998	c.835C>T	c.(835-837)Ctg>Ttg	p.L279L	BLVRA_ENST00000265523.4_Silent_p.L279L	NM_001253823.1	NP_001240752.1	P53004	BIEA_HUMAN	biliverdin reductase A	279					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			endometrium(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(2)	12					NADH(DB00157)	GAAACGCATCCTGCACTGCCT	0.433000													32	75					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321663	52321663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:52321663G>A	ENST00000356297.4	-	17	2621	c.2521C>T	c.(2521-2523)Cct>Tct	p.P841S	PXDNL_ENST00000543296.1_Missense_Mutation_p.P841S	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	841					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGGAAACAAGGAGGGTCGTTG	0.692000													9	27					0	0	1	0	0
TNFRSF18	8784	broad.mit.edu	37	1	1139810	1139810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1139810C>T	ENST00000379268.2	-	3	486	c.367G>A	c.(367-369)Ggc>Agc	p.G123S	TNFRSF18_ENST00000486728.1_Missense_Mutation_p.G51S|TNFRSF18_ENST00000379265.5_Missense_Mutation_p.G123S|TNFRSF18_ENST00000328596.6_Missense_Mutation_p.G123S	NM_004195.2|NM_148902.1	NP_004186.1|NP_683700.1	Q9Y5U5	TNR18_HUMAN	tumor necrosis factor receptor superfamily, member 18	123					anti-apoptosis|apoptosis	extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCTTCGTGGCCCCCGGAGAAG	0.652000													18	35					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44102413	44102413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:44102413C>T	ENST00000272286.2	+	11	1707	c.1617C>T	c.(1615-1617)gtC>gtT	p.V539V		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	539	ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GGCTGGTGGTCTTCTGTTGCA	0.612000													13	95					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27218585	27218585	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:27218585G>A	ENST00000230582.3	+	5	606	c.591_splice	c.e5+1	p.K197_splice	PRSS16_ENST00000421826.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	197					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CCCGGCTGAAGGTCCTGCGAC	0.652000													15	43					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575102	136575102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136575102C>T	ENST00000264162.2	-	6	1526	c.1516G>A	c.(1516-1518)Gat>Aat	p.D506N		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	506	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCACCATGATCCTGCAGGGCC	0.587000													23	44					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89671018	89671018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:89671018C>T	ENST00000264344.5	-	16	2190	c.1983G>A	c.(1981-1983)gaG>gaA	p.E661E	FAM13A_ENST00000508369.1_Silent_p.E335E|FAM13A_ENST00000513837.1_Silent_p.E307E|FAM13A_ENST00000395002.2_Silent_p.E335E|FAM13A_ENST00000503556.1_Silent_p.E321E|FAM13A_ENST00000511976.1_Silent_p.E247E	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	661					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						GTGTCAGGTCCTCTTGCTCAT	0.502000													23	55					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100200274	100200274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100200274G>A	ENST00000547776.2	-	4	576	c.577C>T	c.(577-579)Cgc>Tgc	p.R193C	ANKS1B_ENST00000329257.7_Missense_Mutation_p.R193C|ANKS1B_ENST00000547010.1_Intron	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	193						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GTGTGCTTGCGAGTGTTGCAG	0.527000													16	59					0	0	1	0	0
NDN	4692	broad.mit.edu	37	15	23931438	23931438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23931438G>A	ENST00000331837.4	-	1	1012	c.927C>T	c.(925-927)ccC>ccT	p.P309P		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	309					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		AGTGGGCAGTGGGATTAGCCT	0.597000									Prader-Willi syndrome				23	56					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52472066	52472066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52472066G>A	ENST00000231721.2	-	14	1658	c.1659C>T	c.(1657-1659)agC>agT	p.S553S		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	553					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GCTTGCCAAGGCTGGGGCGGT	0.667000													9	32					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104999239	104999239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:104999239C>T	ENST00000372582.1	+	10	2017	c.1261C>T	c.(1261-1263)Cct>Tct	p.P421S	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.P421S|IL1RAPL2_ENST00000485671.1_3'UTR|IL1RAPL2_ENST00000538500.1_Missense_Mutation_p.P26S	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	421	TIR.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						CTGTGACAATCCTGAAGAAGA	0.388000													47	38					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188055	140188055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140188055G>A	ENST00000530339.1	+	1	1283	c.1283G>A	c.(1282-1284)cGa>cAa	p.R428Q	PCDHA4_ENST00000512229.2_Missense_Mutation_p.R428Q|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.R428Q|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGACCGCGCGAGACGGGGGC	0.617000													45	154					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841843	94841843	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94841843G>A	ENST00000357742.4	+	1	349	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K	MCTP2_ENST00000543482.1_Missense_Mutation_p.E117K|MCTP2_ENST00000451018.3_Missense_Mutation_p.E117K|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	117					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CCATGTGGTGGAAACAGACTC	0.532000													36	203					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78062033	78062033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:78062033G>A	ENST00000299642.4	+	2	257	c.172G>A	c.(172-174)Gaa>Aaa	p.E58K	CLEC3A_ENST00000575655.1_Missense_Mutation_p.E49K|RP11-281J9.2_ENST00000563114.1_RNA	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	49					skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						GACTCAAATTGAAAAGCTCTG	0.443000													33	54					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124351406	124351406	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124351406G>A	ENST00000360013.3	+	35	5443	c.5316G>A	c.(5314-5316)acG>acA	p.T1772T	KALRN_ENST00000428018.2_Silent_p.T75T|KALRN_ENST00000393496.1_Silent_p.T145T|KALRN_ENST00000291478.4_Silent_p.T75T	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1772					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGTGGCTGACGAGTCCTGTGC	0.577000													18	87					0	0	1	0	0
HCAR1	27198	broad.mit.edu	37	12	123214634	123214634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123214634C>T	ENST00000432564.1	-	1	495	c.253G>A	c.(253-255)Gac>Aac	p.D85N	HCAR1_ENST00000436083.2_Missense_Mutation_p.D85N|HCAR1_ENST00000356987.2_Missense_Mutation_p.D85N	NM_032554.3	NP_115943.1	Q9BXC0	HCAR1_HUMAN	hydroxycarboxylic acid receptor 1	85					response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)	10						CAGGGAATGTCCCCAAAAGCC	0.527000													14	28					0	0	1	0	0
HAPLN3	145864	broad.mit.edu	37	15	89424951	89424951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89424951G>A	ENST00000359595.3	-	3	344	c.130C>T	c.(130-132)Ctt>Ttt	p.L44F	HAPLN3_ENST00000562889.1_Missense_Mutation_p.L106F	NM_178232.2	NP_839946.1	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	44					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	17	Lung NSC(78;0.0392)|all_lung(78;0.077)					ACTCCATTAAGGAGGTCTTGG	0.622000													26	74					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6867615	6867615	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6867615G>A	ENST00000299454.4	+	1	733	c.702G>A	c.(700-702)ggG>ggA	p.G234G	OR10A5_ENST00000379831.2_Silent_p.G238G			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAGCTAAAGGGAAGCATAAAG	0.453000													69	188					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984115	85984115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85984115G>A	ENST00000372113.4	-	2	871	c.866C>T	c.(865-867)cCc>cTc	p.P289L	LRIT2_ENST00000538192.1_Missense_Mutation_p.P289L	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	289	Ig-like.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						CATACTCAGGGGATAAGTCCA	0.527000													19	40					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241812411	241812411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241812411C>T	ENST00000307503.3	+	5	927	c.540C>T	c.(538-540)ctC>ctT	p.L180L		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	180					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AGTGCCTGCTCCTGGTGGATT	0.657000													29	124					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655181	19655181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19655181C>T	ENST00000586018.1	+	8	1947	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F	CILP2_ENST00000291495.4_Silent_p.F609F			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	609						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GGGTGACGTTCGTGGACCCCC	0.692000													53	111					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403772	47403772	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47403772C>T	ENST00000310638.4	-	2	264	c.233G>A	c.(232-234)tGg>tAg	p.W78*	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Nonsense_Mutation_p.W78*|CYP4A11_ENST00000371905.1_Nonsense_Mutation_p.W78*|CYP4A11_ENST00000457840.2_5'UTR	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	78					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	TGTCTCCACCCATTTCTGAAT	0.483000													32	94					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35774065	35774065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35774065G>A	ENST00000440995.2	+	28	4005	c.4005G>A	c.(4003-4005)agG>agA	p.R1335R	SPEF2_ENST00000356031.3_Silent_p.R1340R|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1340					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAATCAAAAGGAAAAATGAAC	0.388000													9	68					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38743485	38743485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38743485C>T	ENST00000449082.2	-	26	4501	c.4502G>A	c.(4501-4503)aGt>aAt	p.S1501N		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1501					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTTTTCTTCACTTTGGTCATC	0.448000													30	70					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114305109	114305109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114305109G>A	ENST00000309235.5	+	6	2052	c.1894G>A	c.(1894-1896)Gaa>Aaa	p.E632K	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	632					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						TCATTCAGGAGAAAAACCCTA	0.373000													13	58					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56247040	56247040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56247040G>A	ENST00000361673.3	-	4	1181	c.968C>T	c.(967-969)tCa>tTa	p.S323L		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	323							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GTCATCATCTGAAAACTCCTC	0.458000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	204					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36552954	36552954	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:36552954C>T	ENST00000258749.5	-	21	2031	c.1632G>A	c.(1630-1632)tgG>tgA	p.W544*	AOAH_ENST00000535891.1_Nonsense_Mutation_p.W512*|AOAH_ENST00000538464.1_Nonsense_Mutation_p.W266*|AOAH_ENST00000431169.1_Missense_Mutation_p.G584E	NM_001637.3	NP_001628.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	544					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GCACCTTTTTCCAGAAATGAT	0.498000													26	61					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17690098	17690098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17690098G>A	ENST00000375448.4	+	16	1866	c.1840G>A	c.(1840-1842)Gag>Aag	p.E614K		NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	614					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CTGCCTGGAGGAGAAGGTGTG	0.617000													11	24					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132016264	132016264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:132016264C>T	ENST00000374786.1	+	2	735	c.256C>T	c.(256-258)Cct>Tct	p.P86S	NTM_ENST00000539799.1_Missense_Mutation_p.P86S|NTM_ENST00000374784.1_Missense_Mutation_p.P86S|NTM_ENST00000374791.3_Missense_Mutation_p.P86S|NTM_ENST00000425719.2_Missense_Mutation_p.P86S|NTM_ENST00000427481.2_Missense_Mutation_p.P77S	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	86	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						GTGCCTGGATCCTCGCGTGGT	0.572000													21	57					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157648592	157648592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157648592C>T	ENST00000368184.3	-	15	2404	c.2113G>A	c.(2113-2115)Ggg>Agg	p.G705R	FCRL3_ENST00000368186.5_Missense_Mutation_p.G705R|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	705						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CTAGCCTCCCCTGCAGAGTCG	0.468000													18	46					0	0	1	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87151852	87151852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87151852G>A	ENST00000285393.3	+	3	611	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K	CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	157					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						CATTCTGATCGAAACGCCATT	0.418000													30	74					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201046127	201046127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201046127C>T	ENST00000362061.3	-	12	1974	c.1748G>A	c.(1747-1749)gGg>gAg	p.G583E	CACNA1S_ENST00000367338.3_Missense_Mutation_p.G583E	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	583					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GTCATACCTCCCCCCAAAGAG	0.572000													35	100					0	0	1	0	0
TMEM5	10329	broad.mit.edu	37	12	64173857	64173857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:64173857C>T	ENST00000261234.6	+	1	275	c.117C>T	c.(115-117)tcC>tcT	p.S39S	RP11-415I12.3_ENST00000509615.2_RNA	NM_014254.1	NP_055069.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	39						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		cggccgggtccccgcggggcc	0.721000													6	12					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19206959	19206959	+	Missense_Mutation	SNP	C	C	T	rs117940121	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19206959C>T	ENST00000318596.7	+	2	177	c.26C>T	c.(25-27)cCg>cTg	p.P9L		NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	9					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			AAGGAAGGCCCGGTGCGATTG	0.612000													8	30					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222818993	222818993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:222818993C>T	ENST00000344922.5	+	7	3600	c.3575C>T	c.(3574-3576)tCg>tTg	p.S1192L	MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344441.6_Missense_Mutation_p.S1192L|MIA3_ENST00000340535.7_Missense_Mutation_p.S70L|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1192					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		GGAATTGCTTCGTTTGCCATT	0.383000													17	46					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112989677	112989677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112989677C>T	ENST00000495514.1	+	6	1257	c.553C>T	c.(553-555)Ctc>Ttc	p.L185F	BOC_ENST00000355385.3_Missense_Mutation_p.L185F|BOC_ENST00000273395.4_Missense_Mutation_p.L185F			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	185	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			CTCAGGGAACCTCCAGATTGT	0.562000													27	85					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55179342	55179342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55179342C>T	ENST00000391736.1	+	14	1534	c.1219C>T	c.(1219-1221)Ccc>Tcc	p.P407S	LILRB4_ENST00000270452.2_Missense_Mutation_p.P407S|LILRB4_ENST00000391734.3_Missense_Mutation_p.P354S|LILRB4_ENST00000391733.3_Missense_Mutation_p.P408S|LILRB4_ENST00000430952.2_Missense_Mutation_p.P406S	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	407						integral to membrane|plasma membrane	antigen binding|receptor activity	p.P407S(1)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		ATCTGAAGCCCCCCAGGATGT	0.647000													27	102					0	0	1	0	0
C11orf35	256329	broad.mit.edu	37	11	556039	556039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:556039G>A	ENST00000329451.3	-	11	1396	c.1334C>T	c.(1333-1335)tCc>tTc	p.S445F		NM_173573.2	NP_775844.2	Q8IXW0	CK035_HUMAN	chromosome 11 open reading frame 35	445										NS(1)|breast(1)|central_nervous_system(1)|lung(4)|pancreas(1)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCGCGGATGGAGAGGAGGGG	0.776000													8	17					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233515037	233515037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233515037G>A	ENST00000366624.3	+	9	2546	c.2285G>A	c.(2284-2286)gGa>gAa	p.G762E	MLK4_ENST00000366622.1_Missense_Mutation_p.G208E	NM_032435.2	NP_115811.2																					AAACGAGAGGGAATCTTCCAG	0.602000													21	81					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83818732	83818732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:83818732C>T	ENST00000349129.2	+	5	684	c.424C>T	c.(424-426)Cct>Tct	p.P142S	DOPEY1_ENST00000237163.5_Missense_Mutation_p.P142S|DOPEY1_ENST00000369739.3_Missense_Mutation_p.P142S|DOPEY1_ENST00000536812.1_Missense_Mutation_p.P142S	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	142					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AACACTGAAACCTGGTCTACA	0.388000													35	56					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52322009	52322009	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:52322009C>T	ENST00000356297.4	-	17	2275	c.2175G>A	c.(2173-2175)gcG>gcA	p.A725A	PXDNL_ENST00000543296.1_Silent_p.A725A	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	725					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CGCGGTACTTCGCATGGAAAC	0.657000													7	40					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149508805	149508805	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149508805G>A	ENST00000378016.2	+	0	9544							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTGTGCGGAGGGTAAGGAAGC	0.632000													16	123					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17052326	17052326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:17052326C>T	ENST00000418129.2	+	2	1575	c.1110C>T	c.(1108-1110)ttC>ttT	p.F370F	PLCL2_ENST00000396755.2_Silent_p.F370F|PLCL2_ENST00000460467.1_Intron|PLCL2_ENST00000432376.1_Silent_p.F370F	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	496					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						AGATAGTTTTCCGCAGTGTCA	0.398000													31	63					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119953055	119953055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119953055C>T	ENST00000307142.4	+	4	3321	c.3125C>T	c.(3124-3126)tCa>tTa	p.S1042L	SYNPO2_ENST00000429713.2_Missense_Mutation_p.S1042L|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Missense_Mutation_p.S1042L	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	1042						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GAGGCCTCCTCACCAGTCAGT	0.542000													20	59					0	0	1	0	0
FBLN5	10516	broad.mit.edu	37	14	92353616	92353616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92353616G>A	ENST00000267620.10	-	8	952	c.783C>T	c.(781-783)acC>acT	p.T261T	FBLN5_ENST00000342058.4_Silent_p.T220T|FBLN5_ENST00000556154.1_Silent_p.T225T			Q9UBX5	FBLN5_HUMAN	fibulin 5	220	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				TGTTGACGCAGGTTTGCACGC	0.522000													49	97					0	0	1	0	0
TIPRL	261726	broad.mit.edu	37	1	168153170	168153170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168153170C>T	ENST00000367833.2	+	2	280	c.135C>T	c.(133-135)ctC>ctT	p.L45L	TIPRL_ENST00000367830.3_Silent_p.L45L	NM_152902.3	NP_690866.1	O75663	TIPRL_HUMAN	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	45					DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			breast(1)|kidney(1)|large_intestine(1)|ovary(2)|skin(1)	6	all_hematologic(923;0.215)					TGCCATCTCTCCCTGAAATGA	0.388000													40	98					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196671484	196671484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196671484G>A	ENST00000312428.6	-	54	10256	c.10156C>T	c.(10156-10158)Cgt>Tgt	p.R3386C		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3386			R -> H (in dbSNP:rs6708527).		ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTCAAGCAACGAATAATAAGC	0.393000													12	46					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107848059	107848059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107848059G>A	ENST00000379028.3	-	13	1590	c.1120C>T	c.(1120-1122)Cca>Tca	p.P374S	NRCAM_ENST00000413765.2_Missense_Mutation_p.P355S|NRCAM_ENST00000379022.4_Missense_Mutation_p.P374S|NRCAM_ENST00000379024.4_Missense_Mutation_p.P355S|NRCAM_ENST00000351718.4_Missense_Mutation_p.P368S|NRCAM_ENST00000425651.2_Missense_Mutation_p.P374S			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	374	Ig-like 4.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						TCCTCTCCTGGGGACAGCACA	0.438000													4	53					0	0	1	0	0
MFSD6L	162387	broad.mit.edu	37	17	8700810	8700810	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8700810C>T	ENST00000329805.4	-	1	1857	c.1629G>A	c.(1627-1629)cgG>cgA	p.R543R		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	543						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						GGGGCAGCCTCCGCTGTATGG	0.602000													31	22					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37447489	37447489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:37447489G>A	ENST00000374660.1	+	15	1806	c.1707G>A	c.(1705-1707)ttG>ttA	p.L569L	ANKRD30A_ENST00000361713.1_Silent_p.L569L|ANKRD30A_ENST00000602533.1_Silent_p.L569L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	625						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CCTTAGAATTGAAGGACATGC	0.289000													30	97					0	0	1	0	0
CLDN1	9076	broad.mit.edu	37	3	190039813	190039813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:190039813C>T	ENST00000295522.3	-	1	451	c.183G>A	c.(181-183)caG>caA	p.Q61Q		NM_021101.4	NP_066924.1	O95832	CLD1_HUMAN	claudin 1	61					calcium-independent cell-cell adhesion|interspecies interaction between organisms	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity			lung(9)	9	all_cancers(143;2.95e-10)|Ovarian(172;0.0512)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.015)		TGCACTGGATCTGCCCGGTGC	0.622000													6	89					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44975656	44975656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:44975656C>T	ENST00000340446.4	-	1	826	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	179						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		AGGGCATCTTCCTTTGACTTT	0.398000													73	186					0	0	1	0	0
CPNE3	8895	broad.mit.edu	37	8	87557009	87557009	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87557009C>T	ENST00000521271.1	+	9	837	c.675C>T	c.(673-675)ctC>ctT	p.L225L	CPNE3_ENST00000198765.4_Silent_p.L225L	NM_003909.3	NP_003900.1	O75131	CPNE3_HUMAN	copine III	225	C2 2.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	23						CACATGATCTCATTGGAACAT	0.308000													48	104					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19746291	19746291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19746291C>T	ENST00000203556.4	-	15	1630	c.1493G>A	c.(1492-1494)cGa>cAa	p.R498Q	GMIP_ENST00000587238.1_Missense_Mutation_p.R472Q|GMIP_ENST00000445806.2_Missense_Mutation_p.R469Q|GMIP_ENST00000586269.1_5'UTR	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	498					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GCCCCGCAGTCGCCGCAGCTG	0.647000													20	58					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997556	115997556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:115997556C>T	ENST00000264363.2	-	2	1315	c.637G>A	c.(637-639)Ggc>Agc	p.G213S		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	213	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGAAGAGGGCCTTTCTCAACC	0.408000													34	100					0	0	1	0	0
CXXC5	51523	broad.mit.edu	37	5	139060312	139060312	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139060312C>T	ENST00000302517.3	+	2	918	c.204C>T	c.(202-204)ccC>ccT	p.P68P	CXXC5_ENST00000511048.1_Silent_p.P68P	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	68					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGTGAGCCCCTCAACAAGA	0.632000													29	96					0	0	1	0	0
GALNT7	51809	broad.mit.edu	37	4	174169415	174169415	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:174169415C>T	ENST00000265000.4	+	2	494	c.411C>T	c.(409-411)ccC>ccT	p.P137P	GALNT7_ENST00000512285.1_Silent_p.P137P	NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	137					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		ACTTTGAACCCAAAGAACCTG	0.483000													34	95					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21795948	21795948	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21795948G>A	ENST00000206660.6	+	17	2877	c.2877G>A	c.(2875-2877)aaG>aaA	p.K959K	RPGRIP1_ENST00000557771.1_Silent_p.K921K|RPGRIP1_ENST00000556336.1_Silent_p.K616K|RPGRIP1_ENST00000307974.4_Silent_p.K318K|RPGRIP1_ENST00000400017.2_Silent_p.K959K|RPGRIP1_ENST00000382933.4_Silent_p.K285K			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	959	Interaction with RPGR.				response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		AAGAGGAAAAGGCTTCATTTC	0.463000													4	26					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35473605	35473605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35473605C>T	ENST00000229771.6	-	11	1104	c.1025G>A	c.(1024-1026)cGa>cAa	p.R342Q	TULP1_ENST00000322263.4_Missense_Mutation_p.R289Q	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	342					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						GCTCCGTTTTCGTTTCCTGCC	0.567000													27	52					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269936	150269936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150269936G>A	ENST00000255945.2	+	3	953	c.778G>A	c.(778-780)Gaa>Aaa	p.E260K	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Missense_Mutation_p.E274K	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	260							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGAGGAGTATGAAGAGAAAAT	0.468000													6	45					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36223190	36223190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36223190C>T	ENST00000420124.1	+	28	5740	c.5740C>T	c.(5740-5742)Cgt>Tgt	p.R1914C	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Missense_Mutation_p.R1914C																							CAGACGTTCCCGTCGTCCCAG	0.642000													7	13					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10647978	10647978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10647978G>A	ENST00000547195.1	-	8	1130	c.630C>T	c.(628-630)acC>acT	p.T210T	MRVI1_ENST00000541483.1_Intron|MRVI1_ENST00000421747.1_Silent_p.T292T|MRVI1_ENST00000423302.2_Silent_p.T301T|MRVI1_ENST00000436272.1_Silent_p.T274T|MRVI1_ENST00000534266.2_5'UTR|MRVI1_ENST00000424001.1_5'UTR|MRVI1_ENST00000531107.1_Silent_p.T293T|MRVI1_ENST00000527509.2_Silent_p.T210T|MRVI1_ENST00000558540.1_5'UTR|MRVI1_ENST00000552103.1_Silent_p.T210T|MRVI1_ENST00000545852.1_5'UTR	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	274					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTTTGGGTGTGGTCTCGGGGT	0.567000													5	25					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158607836	158607836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158607836C>T	ENST00000368148.3	-	36	5356	c.5176G>A	c.(5176-5178)Gaa>Aaa	p.E1726K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1726K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1726					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					ATCCAGGATTCCTCATCATCT	0.418000													10	150					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43898243	43898243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43898243C>T	ENST00000562955.1	+	37	5327	c.5327C>T	c.(5326-5328)cCc>cTc	p.P1776L	SZT2_ENST00000372442.1_Missense_Mutation_p.P934L	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1833						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GAGGGTGTCCCCCTCATCAGC	0.607000													60	130					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220791985	220791985	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:220791985G>A	ENST00000402574.1	+	9	1394	c.392G>A	c.(391-393)cGa>cAa	p.R131Q	MARK1_ENST00000366918.4_Missense_Mutation_p.R244Q|MARK1_ENST00000366917.4_Missense_Mutation_p.R266Q	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	266	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		AAGGAACTGCGAGAGCGAGTT	0.338000													33	100					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052376	44052376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:44052376G>A	ENST00000306006.6	-	2	1804	c.1152C>T	c.(1150-1152)ttC>ttT	p.F384F	ZNF239_ENST00000374446.2_Silent_p.F384F|ZNF239_ENST00000535642.1_Silent_p.F384F|ZNF239_ENST00000426961.1_Silent_p.F384F	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						AGCTCTGGCTGAAACCCTTCC	0.527000													24	68					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124258721	124258721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124258721G>A	ENST00000409039.3	+	5	373	c.348G>A	c.(346-348)atG>atA	p.M116I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	116	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTACCGACATGAAGGAAGCTA	0.403000													20	84					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30371579	30371579	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30371579C>A	ENST00000340513.4	+	13	1904	c.1376C>A	c.(1375-1377)cCt>cAt	p.P459H	TPX2_ENST00000300403.6_Missense_Mutation_p.P423H			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	423					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			AAGAAACCACCTGTGAAACCA	0.408000													41	106					7.63091e-17	7.67325e-17	1	1	0
PCDHGB3	56102	broad.mit.edu	37	5	140751918	140751918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140751918C>T	ENST00000576222.1	+	1	2088	c.1957C>T	c.(1957-1959)Cct>Tct	p.P653S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGACAGCAGCCTCTTTCAGC	0.647000													25	64					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688486	26688486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26688486C>T	ENST00000529632.2	+	2	405	c.209C>T	c.(208-210)cCc>cTc	p.P70L	SEZ6L_ENST00000360929.3_Missense_Mutation_p.P70L|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000404234.3_Missense_Mutation_p.P70L|SEZ6L_ENST00000343706.4_Missense_Mutation_p.P70L|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000248933.6_Missense_Mutation_p.P70L	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	70						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GTAACAGCGCCCCCCAGTTCC	0.632000													8	42					0	0	1	0	0
IGJ	3512	broad.mit.edu	37	4	71532205	71532205	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71532205C>T	ENST00000254801.4	-	1	172	c.3G>A	c.(1-3)atG>atA	p.M1I	ENAM_ENST00000472903.1_Intron|IGJ_ENST00000543780.1_Start_Codon_SNP_p.M1I	NM_144646.3	NP_653247.1	P01591	IGJ_HUMAN	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	1					immune response	extracellular region	antigen binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7			Lung(101;0.235)			AATGGTTCTTCATCTTGACTT	0.388000													25	47					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39796071	39796071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:39796071C>T	ENST00000553728.1	+	24	3494	c.3281C>T	c.(3280-3282)tCa>tTa	p.S1094L	CTAGE5_ENST00000280083.3_Missense_Mutation_p.S559L|CTAGE5_ENST00000396165.4_Missense_Mutation_p.S530L|CTAGE5_ENST00000556148.1_Missense_Mutation_p.S484L|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.S530L|CTAGE5_ENST00000341502.5_Missense_Mutation_p.S559L|CTAGE5_ENST00000396158.2_Missense_Mutation_p.S564L|CTAGE5_ENST00000341749.3_Missense_Mutation_p.S547L|CTAGE5_ENST00000348007.3_Missense_Mutation_p.S516L|CTAGE5_ENST00000557038.1_Missense_Mutation_p.S479L|CTAGE5_ENST00000553352.1_Missense_Mutation_p.S530L																							TAATTAGGCTCACGAGGCCCA	0.358000													21	93					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6309787	6309787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6309787G>A	ENST00000301452.4	-	4	486	c.409C>T	c.(409-411)Ctg>Ttg	p.L137L		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	137						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						GTGGGCCGCAGGAAGGACAGA	0.607000													13	63					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51853778	51853778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51853778C>T	ENST00000453097.2	+	8	1116	c.899C>T	c.(898-900)gCc>gTc	p.A300V	SLC4A8_ENST00000394856.1_Missense_Mutation_p.A247V|SLC4A8_ENST00000358657.3_Missense_Mutation_p.A327V|SLC4A8_ENST00000514353.3_Missense_Mutation_p.A247V|SLC4A8_ENST00000535225.2_Missense_Mutation_p.A247V	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	300					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		GGGGCCGAGGCCTCCAATGTC	0.463000													24	210					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25293954	25293954	+	Missense_Mutation	SNP	G	G	A	rs144859640	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25293954G>A	ENST00000400358.4	+	19	2095	c.2038G>A	c.(2038-2040)Gat>Aat	p.D680N	SGSM1_ENST00000400359.4_Missense_Mutation_p.D735N	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	735	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TGAGTCTGTGGATGAGGTGGA	0.522000													5	9					0	0	1	0	0
STARD3NL	83930	broad.mit.edu	37	7	38247193	38247193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38247193C>T	ENST00000009041.7	+	2	345	c.88C>T	c.(88-90)Ccc>Tcc	p.P30S	STARD3NL_ENST00000544203.1_Missense_Mutation_p.P23S|STARD3NL_ENST00000396013.1_Missense_Mutation_p.P30S|STARD3NL_ENST00000434197.1_Missense_Mutation_p.P30S	NM_032016.3	NP_114405.1	O95772	MENTO_HUMAN	STARD3 N-terminal like	30						integral to membrane|late endosome membrane				endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10						TTCCATCAACCCCACACAACT	0.507000													30	87					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21542995	21542995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21542995C>T	ENST00000298694.4	+	3	1233	c.1106C>T	c.(1105-1107)cCt>cTt	p.P369L	ARHGEF40_ENST00000298693.3_Missense_Mutation_p.P369L			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	369	Gly-rich.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						GAAGGACCACCTGGTACCCCT	0.642000													10	51					0	0	1	0	0
GJA1	2697	broad.mit.edu	37	6	121768414	121768414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:121768414G>A	ENST00000282561.3	+	2	578	c.421G>A	c.(421-423)Gag>Aag	p.E141K		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	141					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CGGTATTGAAGAGCATGGTAA	0.453000													40	46					0	0	1	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869096	22869096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22869096C>T	ENST00000302097.3	-	2	1111	c.859G>A	c.(859-861)Gat>Aat	p.D287N		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GGCTGCCCATCTCCTTTATGC	0.383000													18	191					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350522	30350522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30350522G>A	ENST00000359358.4	-	2	471	c.33C>T	c.(31-33)ttC>ttT	p.F11F	KLHL14_ENST00000358095.4_Silent_p.F11F|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	11						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GGCTGGGGTCGAAGGTGGAGG	0.642000													16	62					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119727714	119727714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:119727714G>A	ENST00000327097.4	+	3	359	c.224G>A	c.(223-225)cGg>cAg	p.R75Q	MARCO_ENST00000541757.1_5'UTR	NM_006770.3	NP_006761.1	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	75					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						GCGCGGCTCCGGGTCCTGGAG	0.562000													19	75					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71209547	71209547	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71209547G>A	ENST00000393567.2	-	5	629	c.479C>T	c.(478-480)tCc>tTc	p.S160F	HYDIN_ENST00000538248.1_Missense_Mutation_p.S187F|HYDIN_ENST00000541601.1_Missense_Mutation_p.S177F|HYDIN_ENST00000288168.10_Missense_Mutation_p.S177F|HYDIN_ENST00000321489.5_Missense_Mutation_p.S160F|HYDIN_ENST00000448691.1_Missense_Mutation_p.S160F|HYDIN_ENST00000448089.2_Missense_Mutation_p.S160F|HYDIN_ENST00000393550.2_Missense_Mutation_p.S160F	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	160										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TCGGAATATGGAAGGCACTCC	0.433000													20	94					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202446936	202446936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202446936G>A	ENST00000439140.1	-	5	565	c.521C>T	c.(520-522)cCc>cTc	p.P174L	ALS2CR11_ENST00000286195.3_Missense_Mutation_p.P174L|ALS2CR11_ENST00000450242.1_Missense_Mutation_p.P174L|ALS2CR11_ENST00000439802.1_Missense_Mutation_p.P174L	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	174										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						ATAACGTCTGGGAACCTCAAT	0.289000													24	78					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31864577	31864577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31864577G>A	ENST00000396184.3	-	14	1514	c.1310C>T	c.(1309-1311)cCc>cTc	p.P437L	PDE1C_ENST00000396191.1_Missense_Mutation_p.P437L|PDE1C_ENST00000321453.7_Missense_Mutation_p.P437L|PDE1C_ENST00000396193.1_Missense_Mutation_p.P497L|PDE1C_ENST00000396182.2_Missense_Mutation_p.P437L	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	437	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			AGTGAAGGTGGGTTCCACGAT	0.458000													13	113					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123484269	123484269	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123484269C>T	ENST00000529750.1	+	15	2028	c.1701C>T	c.(1699-1701)ccC>ccT	p.P567P	GRAMD1B_ENST00000322282.7_Silent_p.P567P|GRAMD1B_ENST00000456860.2_Silent_p.P574P|GRAMD1B_ENST00000450171.2_Silent_p.P258P	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	567						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		GGAAGCGTCCCCATGCCCACC	0.577000													16	33					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143563058	143563058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143563058C>T	ENST00000517894.1	+	11	3010	c.2116C>T	c.(2116-2118)Cct>Tct	p.P706S	BAI1_ENST00000323289.5_Missense_Mutation_p.P706S			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	706					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CAGCCCCACCCCTGGGGACGT	0.607000													4	14					0	0	1	0	0
CD247	919	broad.mit.edu	37	1	167407814	167407814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167407814C>T	ENST00000392122.3	-	4	437	c.293G>A	c.(292-294)gGa>gAa	p.G98E	CD247_ENST00000362089.5_Missense_Mutation_p.G98E|CD247_ENST00000483825.1_5'UTR	NM_000734.3|NM_198053.2	NP_000725.1|NP_932170.1	P20963	CD3Z_HUMAN	CD247 molecule	98					interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(543;0.236)			TACCGGCTTTCCCCCCATCTC	0.562000													52	89					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021806	5021806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5021806G>A	ENST00000382545.3	+	2	2369	c.1262G>A	c.(1261-1263)gGg>gAg	p.G421E	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	421					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAAACTGAGGGGGAAGAGCAG	0.527000													103	240					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3224759	3224759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3224759C>T	ENST00000520002.1	-	21	3468	c.2913G>A	c.(2911-2913)atG>atA	p.M971I	CSMD1_ENST00000542608.1_Missense_Mutation_p.M970I|CSMD1_ENST00000400186.3_Missense_Mutation_p.M971I|CSMD1_ENST00000602557.1_Missense_Mutation_p.M971I|CSMD1_ENST00000537824.1_Missense_Mutation_p.M970I|CSMD1_ENST00000602723.1_Missense_Mutation_p.M971I|CSMD1_ENST00000539096.1_Missense_Mutation_p.M970I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	971	CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTGAAAGATCATTTGAACTC	0.557000													3	15					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582444	136582444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:136582444C>T	ENST00000531224.1	-	12	2968	c.2716G>A	c.(2716-2718)Gaa>Aaa	p.E906K	BCLAF1_ENST00000527536.1_Missense_Mutation_p.E857K|BCLAF1_ENST00000527759.1_Missense_Mutation_p.E904K|BCLAF1_ENST00000031135.9_Missense_Mutation_p.E124K|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000392348.2_Missense_Mutation_p.E855K|BCLAF1_ENST00000530767.1_Missense_Mutation_p.E733K|BCLAF1_ENST00000353331.4_Missense_Mutation_p.E855K	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	906					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCATTATTTTCCATGGTCTCT	0.378000													26	197					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117308979	117308979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:117308979C>T	ENST00000355044.3	+	26	3854	c.3728C>T	c.(3727-3729)tCc>tTc	p.S1243F	ATRNL1_ENST00000303745.7_Missense_Mutation_p.S36F|ATRNL1_ENST00000423111.2_Missense_Mutation_p.S294F	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1243						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGTTTCCTATCCTTATTGCTG	0.313000													25	69					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119288083	119288083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:119288083C>T	ENST00000338891.7	-	15	3393	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K	RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000368475.4_Missense_Mutation_p.E815K|FAM184A_ENST00000521531.1_Missense_Mutation_p.E935K|FAM184A_ENST00000352896.5_Missense_Mutation_p.E815K	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	984										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						GGTTTTGATTCTCTCATTAGA	0.294000													16	20					0	0	1	0	0
CPB1	1360	broad.mit.edu	37	3	148545841	148545841	+	Missense_Mutation	SNP	C	C	T	rs114058679	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:148545841C>T	ENST00000491148.1	+	3	458	c.124C>T	c.(124-126)Cgc>Tgc	p.R42C	CPB1_ENST00000282957.4_Missense_Mutation_p.R42C			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	42					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TAACATAATCCGCGAGTTGGC	0.363000													27	84					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129237967	129237967	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129237967C>T	ENST00000296266.3	+	29	3754	c.3562C>T	c.(3562-3564)Cta>Tta	p.L1188L	IFT122_ENST00000440957.2_Silent_p.L928L|IFT122_ENST00000431818.2_Silent_p.L987L|IFT122_ENST00000504021.1_Silent_p.L1014L|IFT122_ENST00000349441.2_Silent_p.L1027L|IFT122_ENST00000347300.2_Silent_p.L1078L|IFT122_ENST00000507564.1_Silent_p.L1130L|IFT122_ENST00000348417.2_Silent_p.L1137L	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	1137					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						GATTCTGCGGCTAGTGGAGAC	0.582000													38	135					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167039933	167039933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167039933C>T	ENST00000392766.2	-	12	1295	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K	ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Missense_Mutation_p.E290K|ZBBX_ENST00000455345.2_Missense_Mutation_p.E319K|ZBBX_ENST00000392767.2_Missense_Mutation_p.E319K|ZBBX_ENST00000307529.5_Missense_Mutation_p.E319K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	319						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CATAATTTTTCCATATAGGAT	0.289000													29	68					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114290845	114290845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:114290845G>A	ENST00000297405.5	-	3	734	c.490C>T	c.(490-492)Cat>Tat	p.H164Y	CSMD3_ENST00000455883.2_Missense_Mutation_p.H164Y|CSMD3_ENST00000343508.3_Missense_Mutation_p.H124Y|CSMD3_ENST00000352409.3_Missense_Mutation_p.H164Y	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	164	CUB 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTAAATCCATGAGCACTAACT	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	74					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115614311	115614311	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:115614311C>T	ENST00000265440.7	-	3	361		c.e3-1		TFEC_ENST00000484212.1_Splice_Site|TFEC_ENST00000320239.7_Intron|TFEC_ENST00000393485.1_Intron	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			CGTCCTCCATCTAGCAAAATA	0.323000													20	49					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048259	9048259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9048259C>T	ENST00000397910.4	-	5	33575	c.33372G>A	c.(33370-33372)gaG>gaA	p.E11124E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11126	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAGGTGTGGTCTCTGGCTCAC	0.512000													30	73					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14567016	14567016	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14567016G>A	ENST00000273083.3	-	0	250							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						ACCTGAGATAGTCAGGCCCAG	0.617000													27	59					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68208743	68208743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68208743G>A	ENST00000262215.3	-	5	951	c.562C>T	c.(562-564)Ctc>Ttc	p.L188F		NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	188					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TGATTGATGAGATTTTTGCTT	0.373000													9	101					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149509044	149509044	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149509044C>T	ENST00000378016.2	+	0	9590							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGTGTTCAGCCTCCTGTGGC	0.697000													19	39					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433422	140433422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140433422G>A	ENST00000306549.3	+	1	2444	c.2367G>A	c.(2365-2367)atG>atA	p.M789I		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		789					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGATAAAAATGGAGGCTGGCT	0.448000													40	98					0	0	1	0	0
APOL1	8542	broad.mit.edu	37	22	36653169	36653169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36653169G>A	ENST00000319136.4	+	4	400	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	APOL1_ENST00000397279.4_Missense_Mutation_p.E29K|APOL1_ENST00000440669.2_Missense_Mutation_p.E29K|APOL1_ENST00000422706.1_Missense_Mutation_p.E29K|APOL1_ENST00000347595.7_Intron|APOL1_ENST00000426053.1_Intron|APOL1_ENST00000397278.3_Missense_Mutation_p.E29K	NM_145343.2	NP_663318.1	O14791	APOL1_HUMAN	apolipoprotein L, 1	29					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	14						GAGGGCAGAGGAAGCTGGAGC	0.502000													12	37					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141803210	141803210	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141803210C>T	ENST00000475668.2	+	70	8209	c.8155C>T	c.(8155-8157)Ccc>Tcc	p.P2719S	MGAM_ENST00000549489.2_Missense_Mutation_p.P1823S			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1823					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGTCATAACACCCTCCTTCAA	0.493000													9	22					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70986992	70986992	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70986992C>T	ENST00000354624.5	+	2	226	c.93C>T	c.(91-93)ctC>ctT	p.L31L	HKDC1_ENST00000395086.2_Silent_p.L31L|RP11-227H15.4_ENST00000450995.1_RNA	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	31					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						ACATGCGGCTCTCCGATGACA	0.617000													16	112					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140952615	140952615	+	Silent	SNP	C	C	T	rs35538393		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140952615C>T	ENST00000277549.5	+	29	4378	c.1809C>T	c.(1807-1809)ttC>ttT	p.F603F	CACNA1B_ENST00000371357.1_Silent_p.F1408F|CACNA1B_ENST00000371363.1_Silent_p.F1407F|CACNA1B_ENST00000277551.2_Silent_p.F1407F|CACNA1B_ENST00000371355.4_Silent_p.F1408F|CACNA1B_ENST00000371372.1_Silent_p.F1407F			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1407					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCTTCTTCTTCGTCAACATCT	0.537000													36	86					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31299723	31299723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:31299723C>T	ENST00000265071.2	+	5	1061	c.796C>T	c.(796-798)Ccc>Tcc	p.P266S	CDH6_ENST00000514738.1_Missense_Mutation_p.P211S	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	266	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CGACAACCCTCCCCGATTCCC	0.428000													25	81					0	0	1	0	0
TPTE2P2	644623	broad.mit.edu	37	13	52854009	52854009	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52854009C>T	ENST00000451298.1	-	0	528				RP11-64P12.8_ENST00000606031.1_RNA																							ACTGGCCTCCCGAAGATGGAA	0.303000													3	18					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107040194	107040194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107040194C>T	ENST00000409886.3	-	20	4316	c.4229G>A	c.(4228-4230)aGa>aAa	p.R1410K	RGPD3_ENST00000304514.7_Missense_Mutation_p.R1410K	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1410	RanBD1 2.				intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TGGAGTTATTCTGTGATTGGC	0.373000													113	280					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50826512	50826512	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50826512G>A	ENST00000376959.2	-	2	1861	c.1698C>T	c.(1696-1698)ccC>ccT	p.P566P	KCNC3_ENST00000391818.2_Intron|KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000477616.1_Silent_p.P566P			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	566					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CCGGTTGCGGGGGCCGGGGGA	0.657000													9	12					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48250140	48250140	+	Missense_Mutation	SNP	G	G	A	rs61739612	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48250140G>A	ENST00000394747.1	-	6	1185	c.836C>T	c.(835-837)cCc>cTc	p.P279L	ABCC11_ENST00000394748.1_Missense_Mutation_p.P279L|ABCC11_ENST00000353782.5_Missense_Mutation_p.P279L|ABCC11_ENST00000537808.1_Missense_Mutation_p.P279L|ABCC11_ENST00000356608.2_Missense_Mutation_p.P279L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	279	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CAGTACTAGGGGTCCATAGCA	0.483000													39	143					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741049	140741049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140741049C>T	ENST00000522605.1	+	1	1347	c.1347C>T	c.(1345-1347)gcC>gcT	p.A449A	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGATAATGCCCCAGTTTTCC	0.552000													46	123					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196388524	196388524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:196388524C>T	ENST00000328557.4	+	3	2213	c.2010C>T	c.(2008-2010)atC>atT	p.I670I		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		GCACTGTCATCGTCCTCACTT	0.597000													45	78					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40412180	40412180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40412180G>A	ENST00000221347.6	-	7	3455	c.3448C>T	c.(3448-3450)Ccg>Tcg	p.P1150S		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1150	Cys-rich.|TIL 2.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CAGGACAGCGGGCAGCCGTAG	0.622000													15	56					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96581799	96581799	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:96581799G>A	ENST00000456556.1	-	38	2462	c.2376_splice	c.e38-1	p.A793_splice	ANKRD36C_ENST00000295246.5_5'UTR|ANKRD36C_ENST00000419039.2_5'UTR|ANKRD36C_ENST00000420871.2_5'UTR					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						ATCACTTGTAGCCTGAATGGA	0.308000													8	9					0	0	1	0	0
C1orf43	25912	broad.mit.edu	37	1	154186378	154186378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154186378G>A	ENST00000368521.5	-	4	529	c.331C>T	c.(331-333)Cgt>Tgt	p.R111C	C1orf43_ENST00000350592.3_Missense_Mutation_p.R77C|C1orf43_ENST00000368519.1_Intron|C1orf43_ENST00000362076.4_Intron|C1orf43_ENST00000368518.1_Missense_Mutation_p.R111C|C1orf43_ENST00000368516.1_Missense_Mutation_p.R77C	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	111						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					CCAGAGGTACGAATGGCATCC	0.463000													33	137					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38768163	38768163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38768163G>A	ENST00000310301.4	-	27	2437	c.2383C>T	c.(2383-2385)Ctt>Ttt	p.L795F	VPS41_ENST00000395969.2_Missense_Mutation_p.L770F	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	795					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						ATAGGGGAAAGGCACGACTCA	0.403000													33	140					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77896092	77896092	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:77896092C>T	ENST00000262198.4	+	4	3251	c.2796C>T	c.(2794-2796)gcC>gcT	p.A932A		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	932					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CTGCCATCGCCGTCCATTTGG	0.562000													8	145					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94849449	94849449	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94849449C>T	ENST00000448921.1	-	4	698	c.126G>A	c.(124-126)caG>caA	p.Q42Q	SERPINA1_ENST00000393088.4_Silent_p.Q42Q|SERPINA1_ENST00000437397.1_Silent_p.Q42Q|SERPINA1_ENST00000355814.4_Silent_p.Q42Q|SERPINA1_ENST00000404814.4_Silent_p.Q42Q|SERPINA1_ENST00000393087.4_Silent_p.Q42Q|SERPINA1_ENST00000402629.1_Silent_p.Q42Q|SERPINA1_ENST00000449399.3_Silent_p.Q42Q|SERPINA1_ENST00000440909.1_Silent_p.Q42Q	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	42					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TTGGGTGATCCTGATCATGGT	0.577000													14	65					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19136660	19136660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19136660G>A	ENST00000601879.1	-	3	794	c.497C>T	c.(496-498)cCc>cTc	p.P166L	SUGP2_ENST00000598202.1_5'UTR|SUGP2_ENST00000600377.1_Missense_Mutation_p.P180L|SUGP2_ENST00000456085.2_Intron|SUGP2_ENST00000452918.2_Missense_Mutation_p.P166L|SUGP2_ENST00000337018.6_Missense_Mutation_p.P166L			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	166					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						AACTGCAGAGGGACCAAAACT	0.502000													37	70					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17498204	17498204	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17498204G>A	ENST00000302539.4	-	1	245	c.120C>T	c.(118-120)ctC>ctT	p.L40L	ABCC8_ENST00000389817.3_Silent_p.L40L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	40					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGGTGATGAAGAGTAGGAAGA	0.672000													6	26					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105010414	105010414	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:105010414C>T	ENST00000507740.1	+	15	2658	c.2420_splice	c.e15-1	p.H808_splice	RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000436393.2_Splice_Site_p.H794_splice	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1076	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGCTTGCAGTCATTTTCTTAC	0.338000										HNSCC(12;0.0054)			39	74					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955629	18955629	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18955629G>A	ENST00000302797.3	-	1	927	c.703C>T	c.(703-705)Cag>Tag	p.Q235*		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	235					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGGAAAAACTGAATGCCAAAG	0.478000													17	37					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34241738	34241738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34241738G>A	ENST00000374114.3	-	3	1770	c.1507C>T	c.(1507-1509)Cat>Tat	p.H503Y	RBM12_ENST00000359646.1_Missense_Mutation_p.H503Y|CPNE1_ENST00000397443.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.H503Y|CPNE1_ENST00000397445.1_Intron|CPNE1_ENST00000397446.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000352393.4_Intron|CPNE1_ENST00000397442.1_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	503	RRM 2.					nucleus	nucleotide binding|protein binding|RNA binding	p.H503N(1)		breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GTAATTGGATGAACTTGAATA	0.398000													60	180					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206628459	206628459	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206628459C>T	ENST00000360409.3	+	13	2897	c.2106C>T	c.(2104-2106)ctC>ctT	p.L702L	NRP2_ENST00000485684.1_3'UTR|NRP2_ENST00000357118.4_Silent_p.L702L|AC007362.3_ENST00000598710.1_RNA|NRP2_ENST00000540841.1_Silent_p.L702L|NRP2_ENST00000540178.1_Silent_p.L702L|NRP2_ENST00000357785.5_Silent_p.L702L|NRP2_ENST00000272849.3_Silent_p.L702L|AC007362.3_ENST00000596616.1_RNA|NRP2_ENST00000412873.2_Silent_p.L702L|AC007362.3_ENST00000423425.1_RNA	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	702	MAM.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						ATGCCCGGCTCATCAGCCCCC	0.622000											OREG0015155	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	111					0	0	1	0	0
FIBIN	387758	broad.mit.edu	37	11	27016596	27016596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:27016596G>A	ENST00000318627.2	+	1	969	c.523G>A	c.(523-525)Gag>Aag	p.E175K		NM_203371.1	NP_976249.1	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog (zebrafish)	175						extracellular region|Golgi apparatus				breast(1)|endometrium(2)|lung(7)|upper_aerodigestive_tract(1)	11						CCTGCTGAAGGAGACACTGGA	0.572000													27	63					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6685006	6685006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6685006G>A	ENST00000245907.6	-	30	4054	c.3962C>T	c.(3961-3963)tCa>tTa	p.S1321L		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1321		Cleavage; by factor I.			complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TACCTCTTCTGATCGCAGGAG	0.597000													19	34					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61223558	61223558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61223558G>A	ENST00000382768.1	+	1	166	c.166G>A	c.(166-168)Gag>Aag	p.E56K	SERPINB12_ENST00000269491.1_Missense_Mutation_p.E56K			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	56					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TCAGATTGATGAGGTACGTGT	0.498000													60	116					0	0	1	0	0
PHC2	1912	broad.mit.edu	37	1	33797043	33797043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33797043G>A	ENST00000257118.5	-	11	1962	c.1909C>T	c.(1909-1911)Ccc>Tcc	p.P637S	PHC2_ENST00000419414.2_Missense_Mutation_p.P638S|PHC2_ENST00000431992.1_Missense_Mutation_p.P608S|PHC2_ENST00000373416.1_Missense_Mutation_p.P102S|PHC2_ENST00000373422.3_Missense_Mutation_p.P243S|PHC2_ENST00000373418.3_Missense_Mutation_p.P102S|PHC2_ENST00000485928.1_5'UTR	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	637					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGTTTGAGGGGAGCACCCTCC	0.532000													57	119					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206327507	206327507	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206327507T>G	ENST00000361052.3	+	6	829	c.711T>G	c.(709-711)atT>atG	p.I237M	CTSE_ENST00000358184.2_Missense_Mutation_p.I232M|CTSE_ENST00000360218.2_Missense_Mutation_p.I232M|CTSE_ENST00000468617.1_3'UTR|CTSE_ENST00000432969.2_Missense_Mutation_p.I157M			P14091	CATE_HUMAN	cathepsin E	237					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GCGAGCTGATTTTTGGAGGCT	0.527000													9	209					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531727	92531727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92531727C>T	ENST00000298047.6	+	9	5565	c.5548C>T	c.(5548-5550)Cat>Tat	p.H1850Y	FAT3_ENST00000525166.1_Missense_Mutation_p.H1700Y|FAT3_ENST00000409404.2_Missense_Mutation_p.H1850Y			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1850	Cadherin 16.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTCCATTTTCATGTGCATGT	0.463000										TCGA Ovarian(4;0.039)			8	25					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735969	13735969	+	Missense_Mutation	SNP	G	G	A	rs78346432		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13735969G>A	ENST00000265104.4	-	67	11632	c.11528C>T	c.(11527-11529)tCg>tTg	p.S3843L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3843			S -> L (in CILD3).		microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTGGCGAAGCGAAGTCTGATA	0.478000									Kartagener syndrome				38	94					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91628487	91628487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91628487G>A	ENST00000375835.4	-	12	1966	c.1660C>T	c.(1660-1662)Cgg>Tgg	p.R554W		NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	554	SH2.			R -> Q (in Ref. 4; AAH26314).	central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						TCCTTTGTCCGGATCTATGAA	0.488000													5	82					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43056984	43056984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43056984G>A	ENST00000316099.3	+	9	1228	c.1139G>A	c.(1138-1140)aGc>aAc	p.S380N	HNF4A_ENST00000415691.1_Missense_Mutation_p.S380N|HNF4A_ENST00000457232.1_Missense_Mutation_p.S358N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	380					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGGTCCCCCAGCGATGCACCC	0.597000													23	74					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640458	104640458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104640458C>T	ENST00000304883.2	-	1	515	c.375G>A	c.(373-375)gtG>gtA	p.V125V		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	125						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AAGCCAGGTTCACAAGGAAGT	0.537000													19	57					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156909560	156909560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156909560G>A	ENST00000368194.3	-	37	4915	c.3876C>T	c.(3874-3876)tcC>tcT	p.S1292S	ARHGEF11_ENST00000361409.2_Silent_p.S1252S|ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000315174.8_Silent_p.S668S	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1252					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTTGCCCTGGGGAGCCTGGGT	0.642000													15	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611552	179611552	+	Missense_Mutation	SNP	C	C	T	rs62179016	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179611552C>T	ENST00000360870.5	-	46	15797	c.15575G>A	c.(15574-15576)aGg>aAg	p.R5192K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8711	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATACCTTCCTTTTGGTCAG	0.388000													52	100					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171546720	171546720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171546720C>T	ENST00000367742.3	+	26	7345	c.7103C>T	c.(7102-7104)tCc>tTc	p.S2368F	PRRC2C_ENST00000426496.2_Missense_Mutation_p.S2301F|PRRC2C_ENST00000338920.4_Missense_Mutation_p.S2366F|PRRC2C_ENST00000392078.3_Missense_Mutation_p.S2368F			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2366	Gln-rich.						protein C-terminus binding										TGTATGCCTTCCCTTATTGCC	0.413000													12	33					0	0	1	0	0
CFC1	55997	broad.mit.edu	37	2	131356248	131356248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131356248C>T	ENST00000259216.4	-	3	476	c.214G>A	c.(214-216)Gag>Aag	p.E72K		NM_032545.3	NP_115934.1	P0CG37	CFC1_HUMAN	cripto, FRL-1, cryptic family 1	72					determination of left/right symmetry|gastrulation	anchored to membrane|extracellular region|plasma membrane				endometrium(1)|lung(4)	5	Colorectal(110;0.1)					GGGAGCGGCTCCTCCGGCCCC	0.627000													20	135					0	0	1	0	0
ZNF92	168374	broad.mit.edu	37	7	64864215	64864215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:64864215C>T	ENST00000328747.7	+	4	1387	c.1188C>T	c.(1186-1188)ccC>ccT	p.P396P	ZNF92_ENST00000357512.2_Silent_p.P364P|ZNF92_ENST00000450302.2_Silent_p.P327P|ZNF92_ENST00000431504.1_Silent_p.P320P	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	396						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				GAGAAAAACCCTACAAATGTG	0.368000													33	78					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513722	78513722	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:78513722G>A	ENST00000397909.2	+	15	3919	c.3746G>A	c.(3745-3747)cGa>cAa	p.R1249Q	NAV3_ENST00000228327.6_Missense_Mutation_p.R1249Q|NAV3_ENST00000536525.2_Missense_Mutation_p.R1249Q|NAV3_ENST00000266692.7_Missense_Mutation_p.R1249Q			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1249	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CCCACATTTCGAAGGTAAGGA	0.403000										HNSCC(70;0.22)			11	50					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233489572	233489572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233489572G>A	ENST00000366624.3	+	3	1267	c.1006G>A	c.(1006-1008)Gaa>Aaa	p.E336K	MLK4_ENST00000366623.3_Missense_Mutation_p.E336K	NM_032435.2	NP_115811.2												p.E336K(1)									GCTGCTGTGGGAACTGCTCAC	0.488000													33	66					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88732726	88732726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88732726C>T	ENST00000226284.5	+	7	685	c.618C>T	c.(616-618)gtC>gtT	p.V206V		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	206					biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		AAGAAAGTGTCACTGGAGCCA	0.537000													14	52					0	0	1	0	0
TRIM60	166655	broad.mit.edu	37	4	165962425	165962425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:165962425C>T	ENST00000512596.1	+	3	1417	c.1201C>T	c.(1201-1203)Cct>Tct	p.P401S	TRIM60_ENST00000508504.1_Missense_Mutation_p.P401S|TRIM60_ENST00000341062.5_Missense_Mutation_p.P401S	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	401	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		TGCGTCAGGTCCTAAGACAAC	0.428000													62	111					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18186640	18186640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18186640C>T	ENST00000600835.1	-	8	922	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	IL12RB1_ENST00000593993.1_Missense_Mutation_p.E207K|IL12RB1_ENST00000430026.2_Missense_Mutation_p.E207K|IL12RB1_ENST00000322153.6_Missense_Mutation_p.E207K			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	207	Fibronectin type-III 2.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						AGCTGGAATTCCTGGGCCACA	0.597000													40	76					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962516	73962516	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73962516G>A	ENST00000373468.1	-	3	2527	c.1876C>T	c.(1876-1878)Cgc>Tgc	p.R626C	KIAA2022_ENST00000055682.5_Missense_Mutation_p.R626C			Q5QGS0	K2022_HUMAN	KIAA2022	626					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTTCGTTTGCGAGCAGGTGGC	0.413000													13	10					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53170910	53170910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53170910G>A	ENST00000332411.2	-	1	219	c.166C>T	c.(166-168)Cgc>Tgc	p.R56C		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	56	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TAGAGGCTGCGACTGCCAAAG	0.667000													47	112					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38968413	38968413	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38968413G>A	ENST00000302328.3	-	4	696	c.498C>T	c.(496-498)ttC>ttT	p.F166F	SCN11A_ENST00000456224.3_Silent_p.F166F|SCN11A_ENST00000444237.2_Silent_p.F166F|SCN11A_ENST00000450244.1_Silent_p.F166F	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	166					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAATCCCAGTGAAGACACACC	0.353000													11	127					0	0	1	0	0
PLAU	5328	broad.mit.edu	37	10	75674610	75674610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75674610G>A	ENST00000446342.1	+	8	1337	c.855G>A	c.(853-855)tcG>tcA	p.S285S	PLAU_ENST00000372762.4_Silent_p.S266S|PLAU_ENST00000372764.3_Silent_p.S302S|C10orf55_ENST00000412307.2_Intron|C10orf55_ENST00000409178.1_Intron	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	302	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	GCCTGCCCTCGATGTATAACG	0.527000													19	43					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213872705	213872705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:213872705G>A	ENST00000457361.1	-	8	1128	c.960C>T	c.(958-960)gcC>gcT	p.A320A	IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000451136.2_Silent_p.A248A|IKZF2_ENST00000342002.2_Silent_p.A326A|IKZF2_ENST00000374327.4_Silent_p.A175A|IKZF2_ENST00000421754.2_Silent_p.A246A|IKZF2_ENST00000434687.1_Silent_p.A320A|IKZF2_ENST00000374319.4_Silent_p.A294A	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CATTGTTGATGGCTTGGTCCA	0.483000													18	67					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96875242	96875242	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96875242G>A	ENST00000267584.4	+	4	506	c.462G>A	c.(460-462)acG>acA	p.T154T	AK7_ENST00000554313.1_3'UTR	NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	154					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TACTGTCGACGGTGATGACTT	0.473000													17	69					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191187	6191187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6191187G>A	ENST00000530810.1	-	1	451	c.370C>T	c.(370-372)Cgc>Tgc	p.R124C	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCACAAAGCGATCAAAGGCC	0.498000													26	56					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27473142	27473142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:27473142G>A	ENST00000295736.5	-	7	840	c.770C>T	c.(769-771)tCc>tTc	p.S257F	SLC4A7_ENST00000455077.1_Intron|SLC4A7_ENST00000435667.2_Intron|SLC4A7_ENST00000437179.1_Intron|SLC4A7_ENST00000446700.1_Missense_Mutation_p.S249F|SLC4A7_ENST00000425128.2_Missense_Mutation_p.S249F|SLC4A7_ENST00000428386.1_Intron|SLC4A7_ENST00000445684.1_Missense_Mutation_p.S253F|SLC4A7_ENST00000454389.1_Missense_Mutation_p.S266F|SLC4A7_ENST00000440156.1_Missense_Mutation_p.S253F|SLC4A7_ENST00000388777.4_5'UTR	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	257						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						AGAGTGGCGGGAGGCTGAAAG	0.398000													23	74					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398297	89398297	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89398297G>A	ENST00000439576.2	+	12	2855	c.2481G>A	c.(2479-2481)aaG>aaA	p.K827K	ACAN_ENST00000352105.7_Silent_p.K827K|ACAN_ENST00000559004.1_Silent_p.K827K|ACAN_ENST00000561243.1_Silent_p.K827K	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	827					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCCCCTCCAAGGAGCCATCCC	0.622000													6	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059860	9059860	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9059860C>T	ENST00000397910.4	-	3	27789	c.27586G>A	c.(27586-27588)Gaa>Aaa	p.E9196K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9198	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAACTGGTTTCAGGTTCTGAG	0.493000													39	75					0	0	1	0	0
CSNK1A1P1	161635	broad.mit.edu	37	15	37109956	37109956	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:37109956C>T	ENST00000430593.3	-	0	704					NR_027320.1																						GTATAAAATTCTTTGTATGCA	0.373000													16	50					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25232052	25232052	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25232052G>A	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						tgtTTTGGTGGAGTGGTAGGA	0.478000													17	45					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23080255	23080255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23080255G>A	ENST00000219689.7	-	16	3170	c.3171C>T	c.(3169-3171)tcC>tcT	p.S1057S	USP31_ENST00000567975.1_Silent_p.S350S	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1057	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GAGAAGAAGGGGATGTACTTG	0.547000													22	78					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18113370	18113370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18113370C>T	ENST00000403915.1	+	3	1546	c.1095C>T	c.(1093-1095)acC>acT	p.T365T	KCNS3_ENST00000304101.4_Silent_p.T365T|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	365	Segment H5 (pore-forming) (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGTGGGCCACCATCAGCATGA	0.557000													29	69					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34006240	34006240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34006240G>A	ENST00000373381.4	-	60	9692	c.9516C>T	c.(9514-9516)ttC>ttT	p.F3172F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3148	Sushi 25.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGCCCCACATGAAGTCAGACC	0.602000													33	87					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100134904	100134904	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100134904C>T	ENST00000394897.1	-	3	203	c.120_splice	c.e3-1	p.V41_splice	RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000407820.2_Intron|ADH6_ENST00000237653.7_Splice_Site_p.V41_splice|ADH6_ENST00000394899.2_Splice_Site_p.V41_splice			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	41					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	GTGGCCACAACCTGTATGGAA	0.468000													25	48					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48370707	48370707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48370707G>A	ENST00000395702.2	+	2	402	c.175G>A	c.(175-177)Gag>Aag	p.E59K	ZNF488_ENST00000494156.1_Missense_Mutation_p.E59K|ZNF488_ENST00000586537.1_5'UTR			Q96MN9	ZN488_HUMAN	zinc finger protein 488	59					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						CCTGGGCCCTGAGGCTGCTGT	0.677000													22	45					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42807211	42807211	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:42807211C>T	ENST00000514985.1	-	3	460		c.e3-1		SEPP1_ENST00000511224.1_Splice_Site|SEPP1_ENST00000506577.1_Splice_Site|SEPP1_ENST00000507920.1_Intron|SEPP1_ENST00000509276.1_Intron	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1						response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						GTCTTCTAATCTAAAATATTT	0.289000													18	41					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76440770	76440770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76440770G>A	ENST00000389840.5	-	71	11526	c.11402C>T	c.(11401-11403)cCc>cTc	p.P3801L	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.P3810L					dynein, axonemal, heavy chain 17									p.P3810L(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCACTCCTTGGGGAAGATCTC	0.567000													9	31					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47941126	47941126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47941126C>T	ENST00000236877.6	-	7	2385	c.1990G>A	c.(1990-1992)Gag>Aag	p.E664K	SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000539381.1_Missense_Mutation_p.E127K|SLC8A2_ENST00000542837.1_Missense_Mutation_p.E420K	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	664					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		TATGACTCCTCGATGATGACC	0.577000													45	92					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100888	93100888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:93100888C>T	ENST00000544406.2	+	2	747	c.481C>T	c.(481-483)Ccc>Tcc	p.P161S	C12orf74_ENST00000397833.3_Missense_Mutation_p.P161S			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	161										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						CCTGCCCAGCCCCACCCTACG	0.547000													7	41					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177675235	177675235	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:177675235C>T	ENST00000390654.3	-	20	1527	c.1170G>A	c.(1168-1170)ggG>ggA	p.G390G		NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	390	Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CCCCCTTCTCCCCCTTGAGGC	0.647000													35	77					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389047	20389047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20389047C>T	ENST00000315915.4	+	1	307	c.282C>T	c.(280-282)ttC>ttT	p.F94F		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F94L(1)		central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCATATCTTTCAGTGGCTGCA	0.423000													106	212					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198950722	198950722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:198950722C>T	ENST00000428675.1	+	2	2879	c.2481C>T	c.(2479-2481)ccC>ccT	p.P827P	PLCL1_ENST00000437704.2_Silent_p.P729P	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	827					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GGCATGTTCCCCTGCGTTCTT	0.453000													29	74					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176314308	176314308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176314308C>T	ENST00000292432.5	-	12	1722	c.1631G>A	c.(1630-1632)gGg>gAg	p.G544E		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	544	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTCGTGCCCCCGAGGTCCAG	0.647000													18	39					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94377063	94377063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94377063C>T	ENST00000282020.4	+	11	2054	c.1796C>T	c.(1795-1797)tCa>tTa	p.S599L	GRID2_ENST00000510992.1_Missense_Mutation_p.S504L	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	599					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CAAATGGGATCAATGACGTCT	0.418000													24	117					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92826798	92826798	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92826798C>T	ENST00000394468.2	-	5	1215	c.1138_splice	c.e5+1	p.V380_splice	HEPACAM2_ENST00000341723.4_Splice_Site_p.V368_splice|HEPACAM2_ENST00000453812.2_Splice_Site_p.V403_splice|HEPACAM2_ENST00000492616.1_5'UTR|HEPACAM2_ENST00000440868.1_Splice_Site_p.G368_splice	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	380						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						TTTAACCTACCTTTGTAGGGT	0.269000													9	54					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56243668	56243668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56243668G>A	ENST00000332836.2	-	2	1556	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	510						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AAAACCAAAGGAGGTCTCCAG	0.443000													47	108					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40494791	40494791	+	Splice_Site	SNP	C	C	T	rs138332995		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40494791C>T	ENST00000287598.6	+	14	1825	c.1628_splice	c.e14-1	p.P544_splice	BUB1B_ENST00000412359.3_Splice_Site_p.P558_splice	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	544					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTTTTCCAGTCCTCCTGCAGA	0.378000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				32	154					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070072	9070072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9070072C>T	ENST00000397910.4	-	3	17577	c.17374G>A	c.(17374-17376)Gag>Aag	p.E5792K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5794	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGTTGATCTCCTCAGACGTC	0.458000													25	51					0	0	1	0	0
ENTPD6	955	broad.mit.edu	37	20	25201908	25201908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:25201908C>T	ENST00000360031.2	+	11	1163	c.981C>T	c.(979-981)ccC>ccT	p.P327P	ENTPD6_ENST00000354989.5_Silent_p.P311P|ENTPD6_ENST00000376652.4_Silent_p.P328P|ENTPD6_ENST00000433259.2_Intron	NM_001247.2	NP_001238.2	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6 (putative)	328						Golgi membrane|integral to membrane	nucleoside-diphosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|prostate(1)|skin(1)	27						GCTTGTCTCCCAGTTTCAAAG	0.512000													11	60					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36149358	36149358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36149358G>A	ENST00000303965.4	-	18	3500	c.3011C>T	c.(3010-3012)cCc>cTc	p.P1004L		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1004					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGCAAATAAGGGAACAAAATG	0.358000													16	32					0	0	1	0	0
OR9K2	441639	broad.mit.edu	37	12	55523928	55523928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55523928C>T	ENST00000305377.5	+	1	464	c.376C>T	c.(376-378)Ctc>Ttc	p.L126F		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						TGTGGCCCAGCTCTTTCTCTT	0.468000													18	152					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167419974	167419974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:167419974G>A	ENST00000519204.1	+	4	728	c.610G>A	c.(610-612)Ggg>Agg	p.G204R	TENM2_ENST00000545108.1_Missense_Mutation_p.G325R|TENM2_ENST00000520393.1_3'UTR|TENM2_ENST00000518659.1_Missense_Mutation_p.G325R|TENM2_ENST00000520394.1_Missense_Mutation_p.G134R|TENM2_ENST00000403607.2_Missense_Mutation_p.G158R					teneurin transmembrane protein 2																		GACCTCCTCGGGGAGCACACC	0.552000													25	73					0	0	1	0	0
OR5B17	219965	broad.mit.edu	37	11	58125676	58125676	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58125676G>A	ENST00000357377.3	-	1	866	c.867C>T	c.(865-867)acC>acT	p.T289T		NM_001005489.1	NP_001005489.1	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B, member 17	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGTTCCTCAGGGTATAGACTA	0.388000													63	136					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39724502	39724502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39724502C>T	ENST00000246662.4	-	6	1371	c.1306G>A	c.(1306-1308)Gaa>Aaa	p.E436K	KRT9_ENST00000588431.1_Missense_Mutation_p.E203K	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	436	Coil 2.|Rod.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				AGGCTGTATTCCTGATTCTGG	0.547000													21	45					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255006	15255006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15255006C>T	ENST00000378116.4	-	8	2587	c.2581G>A	c.(2581-2583)Gaa>Aaa	p.E861K		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	861						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TCATCGTCTTCCTCTTCCTCG	0.587000													64	172					0	0	1	0	0
ALX4	60529	broad.mit.edu	37	11	44289073	44289073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:44289073G>A	ENST00000329255.3	-	3	980	c.877C>T	c.(877-879)Ctc>Ttc	p.L293F		NM_021926.3	NP_068745.2	Q9H161	ALX4_HUMAN	ALX homeobox 4	293					hair follicle development					central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	16						CGGGTGAGGAGGGGCAGCTCA	0.622000													20	18					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51685950	51685950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51685950C>T	ENST00000267012.4	-	10	1001	c.940G>A	c.(940-942)Gag>Aag	p.E314K	BIN2_ENST00000544402.1_Missense_Mutation_p.E288K|BIN2_ENST00000452142.2_Missense_Mutation_p.E282K|BIN2_ENST00000604560.1_Missense_Mutation_p.E287K	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	314						cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						TCTAAGAGCTCCTTGATCTCA	0.517000													27	66					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125315672	125315672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125315672C>T	ENST00000373688.2	+	1	282	c.224C>T	c.(223-225)cCc>cTc	p.P75L		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						CTCCATACTCCCATGTACTTC	0.507000													29	203					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2740316	2740316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2740316C>T	ENST00000312371.4	+	2	599	c.231C>T	c.(229-231)ttC>ttT	p.F77F	AMZ1_ENST00000407112.1_Silent_p.F77F	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	77							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CCGAGGACTTCCAGACCTTCC	0.667000													28	109					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018542	62018542	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62018542G>A	ENST00000578147.1	-	24	5176	c.5100C>T	c.(5098-5100)acC>acT	p.T1700T	SCN4A_ENST00000435607.1_Silent_p.T1700T			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1700					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.T1700T(1)		breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TCTCCTCCATGGTCTGCTTGA	0.587000													22	66					0	0	1	0	0
G6PC	2538	broad.mit.edu	37	17	41059569	41059569	+	Missense_Mutation	SNP	G	G	A	rs104894568		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:41059569G>A	ENST00000253801.2	+	3	449	c.370G>A	c.(370-372)Gca>Aca	p.A124T	G6PC_ENST00000592383.1_Intron|G6PC_ENST00000585489.1_Missense_Mutation_p.A124T	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	124			A -> T (in GSD1A).		gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CATGGGCACAGCAGGTGTATA	0.498000													20	29					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124325875	124325875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124325875G>A	ENST00000409039.3	+	29	4814	c.4789G>A	c.(4789-4791)Gac>Aac	p.D1597N		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1597	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCAGATGTACGACAACATAGC	0.512000													22	179					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584835	179584835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179584835G>A	ENST00000589042.1	-	81	23758	c.23534C>T	c.(23533-23535)tCa>tTa	p.S7845L	TTN_ENST00000342992.6_Missense_Mutation_p.S6601L|TTN_ENST00000591111.1_Missense_Mutation_p.S7528L|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7528	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCAATGAATGAAATCCTGGT	0.428000													10	86					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41181551	41181551	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41181551G>A	ENST00000263413.3	-	7	1101	c.837C>T	c.(835-837)ttC>ttT	p.F279F	C6_ENST00000337836.5_Silent_p.F279F|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	279	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTGGTACACTGAAAGAGCTCC	0.368000													38	78					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23818459	23818459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:23818459G>A	ENST00000546136.1	-	6	813	c.811C>T	c.(811-813)Cct>Tct	p.P271S	SOX5_ENST00000545921.1_Missense_Mutation_p.P274S|SOX5_ENST00000537393.1_Missense_Mutation_p.P249S|SOX5_ENST00000381381.2_Missense_Mutation_p.P271S|SOX5_ENST00000541536.1_Missense_Mutation_p.P271S|SOX5_ENST00000451604.2_Missense_Mutation_p.P284S|SOX5_ENST00000309359.1_Missense_Mutation_p.P271S			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	284					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						TGATCAGGAGGGAATACGGGA	0.493000													18	130					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531592	50531592	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50531592A>T	ENST00000374144.3	+	3	1290	c.1002A>T	c.(1000-1002)gaA>gaT	p.E334D	C10orf71_ENST00000323868.4_Missense_Mutation_p.E334D			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	334										endometrium(1)	1						GCAGTCAGGAAGAGAACAGAC	0.582000													11	54					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6750520	6750520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:6750520C>T	ENST00000230859.6	+	10	1143	c.1014C>T	c.(1012-1014)ccC>ccT	p.P338P		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	338					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding	p.P338P(1)		cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CCGAGTCTCCCTATGGCCAGC	0.552000													25	57					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42554560	42554560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42554560C>T	ENST00000381668.5	-	17	1712	c.1481G>A	c.(1480-1482)cGa>cAa	p.R494Q	ATP8A1_ENST00000264449.10_Missense_Mutation_p.R479Q	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	494					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	GTCACCTTCTCGCTCTGGCAC	0.363000													31	75					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873438	55873438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55873438G>A	ENST00000313503.1	+	1	920	c.920G>A	c.(919-921)aGa>aAa	p.R307K		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					GTCATGCAGAGAAGACAGGAC	0.353000										HNSCC(53;0.14)			42	121					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45152068	45152068	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45152068C>T	ENST00000296129.1	-	4	1055	c.921G>A	c.(919-921)ggG>ggA	p.G307G	CDCP1_ENST00000425231.2_Silent_p.G307G	NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	307						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GGTTGAAGTTCCCCGCCATGT	0.552000													41	109					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227985818	227985818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227985818C>T	ENST00000396625.3	-	5	446	c.239G>A	c.(238-240)gGa>gAa	p.G80E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G80E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	80	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCCTGGGGCTCCCAGGGGTCC	0.547000													11	45					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133799149	133799149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133799149C>T	ENST00000372338.4	-	4	1073	c.831G>A	c.(829-831)acG>acA	p.T277T	FIBCD1_ENST00000253018.4_Silent_p.T119T|FIBCD1_ENST00000448616.1_Silent_p.T277T|FIBCD1_ENST00000372337.2_Silent_p.T119T	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	277	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CGCCGCCGTCCGTGCGCATGT	0.672000													8	28					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5020937	5020937	+	Silent	SNP	G	G	A	rs142184899	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5020937G>A	ENST00000382545.3	+	2	1500	c.393G>A	c.(391-393)cgG>cgA	p.R131R	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	131					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGAAGTTCCGGGAGGACGAGG	0.652000													40	65					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112185104	112185104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:112185104C>T	ENST00000455480.2	+	17	2670	c.2493C>T	c.(2491-2493)gcC>gcT	p.A831A	ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000313698.4_Silent_p.A800A|ACAD10_ENST00000392636.2_Silent_p.A402A	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	800							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CTCAGGTTGCCTCTTCAGATG	0.542000													40	57					0	0	1	0	0
NIPAL4	348938	broad.mit.edu	37	5	156899773	156899773	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156899773C>T	ENST00000311946.7	+	6	1322	c.1206C>T	c.(1204-1206)ttC>ttT	p.F402F	NIPAL4_ENST00000435489.2_Silent_p.F383F|ADAM19_ENST00000430702.2_Intron	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	402						integral to membrane	receptor activity	p.F340L(2)		breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						TGGGCGTGTTCATGCTGCATG	0.547000													15	39					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188904	32188904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32188904G>A	ENST00000375023.3	-	4	788	c.650C>T	c.(649-651)tCc>tTc	p.S217F		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	217	EGF-like 5; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GCACTGGAAGGAGCCCAGGGT	0.657000													22	31					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64504414	64504414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64504414C>T	ENST00000377494.1	-	8	1828	c.906G>A	c.(904-906)ccG>ccA	p.P302P	RASGRP2_ENST00000394432.3_Silent_p.P302P|RASGRP2_ENST00000377497.3_Silent_p.P302P|RASGRP2_ENST00000354024.3_Silent_p.P302P			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	302	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CACCCAGGATCGGGAAGCGGA	0.662000													8	38					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921236	24921236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24921236C>T	ENST00000329468.2	+	1	696	c.222C>T	c.(220-222)ctC>ctT	p.L74L		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CGTGTCCTCTCCCTCGGGCTG	0.711000													15	38					0	0	1	0	0
IGFL3	388555	broad.mit.edu	37	19	46627344	46627344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46627344G>A	ENST00000341415.2	-	3	173	c.149C>T	c.(148-150)cCt>cTt	p.P50L	AC007193.6_ENST00000597989.1_lincRNA	NM_207393.1	NP_997276.1	Q6UXB1	IGFL3_HUMAN	IGF-like family member 3	50						extracellular region	protein binding			endometrium(1)|large_intestine(1)|lung(5)	7		Ovarian(192;0.0175)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00473)|GBM - Glioblastoma multiforme(486;0.0149)|Epithelial(262;0.239)		CTGCTCTGAAGGGTTGTAGAT	0.557000													44	104					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73045805	73045805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:73045805C>T	ENST00000545377.1	+	3	353	c.177C>T	c.(175-177)gtC>gtT	p.V59V	ARHGEF28_ENST00000296794.6_Silent_p.V59V|ARHGEF28_ENST00000287898.5_Silent_p.V59V|ARHGEF28_ENST00000437974.1_Silent_p.V59V|ARHGEF28_ENST00000426542.2_Silent_p.V59V|ARHGEF28_ENST00000513042.2_Silent_p.V59V	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		AGTCCAGCGTCCCAGGTGAGG	0.483000													18	81					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64643413	64643413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:64643413C>T	ENST00000371079.1	+	9	2064	c.1689C>T	c.(1687-1689)ttC>ttT	p.F563F	ROR1_ENST00000545203.1_Silent_p.F14F	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	563	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						TCCATGAGTTCCTCATCATGA	0.488000													22	70					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180041160	180041160	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180041160C>T	ENST00000261937.6	-	24	3317	c.3239G>A	c.(3238-3240)tGg>tAg	p.W1080*	FLT4_ENST00000393347.3_Nonsense_Mutation_p.W1080*|FLT4_ENST00000502649.1_Nonsense_Mutation_p.W1080*	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1080	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGGGGCCATCCACTTCAGGGG	0.617000													32	81					0	0	1	0	0
SFN	2810	broad.mit.edu	37	1	27190435	27190435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27190435G>A	ENST00000339276.4	+	1	803	c.732G>A	c.(730-732)caG>caA	p.Q244Q		NM_006142.3	NP_006133.1	P31947	1433S_HUMAN	stratifin	244					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(2)	9		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		AGGCTCCCCAGGAGCCCCAGA	0.677000													20	36					0	0	1	0	0
AGT	183	broad.mit.edu	37	1	230846180	230846180	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:230846180G>A	ENST00000366667.4	-	2	631	c.417C>T	c.(415-417)gtC>gtT	p.V139V		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	139					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	GGGTGCCAAAGACAGCCGTTG	0.582000													45	87					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57257852	57257852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57257852C>T	ENST00000343433.6	-	2	714	c.634G>A	c.(634-636)Gat>Aat	p.D212N	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	212										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						AAAGAGGGATCTTCAGAGACG	0.502000													57	136					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39114782	39114782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39114782C>T	ENST00000379907.4	+	19	2209	c.2082C>T	c.(2080-2082)ctC>ctT	p.L694L	ADAM32_ENST00000437682.2_Silent_p.L595L|ADAM32_ENST00000519315.1_Silent_p.L588L	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	694					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TTCCTATTCTCATTGTAACAA	0.388000													26	78					0	0	1	0	0
ACER3	55331	broad.mit.edu	37	11	76709843	76709843	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76709843C>T	ENST00000532485.1	+	7	579	c.475C>T	c.(475-477)Cga>Tga	p.R159*	ACER3_ENST00000544113.1_Nonsense_Mutation_p.R26*|ACER3_ENST00000538157.1_Nonsense_Mutation_p.R117*|ACER3_ENST00000526597.1_Nonsense_Mutation_p.R64*|ACER3_ENST00000533873.1_Nonsense_Mutation_p.R122*	NM_018367.5	NP_060837.3	Q9NUN7	ACER3_HUMAN	alkaline ceramidase 3	159					ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)	9						ATTAGTACTTCGATCTATTTA	0.323000													9	34					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51974734	51974734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51974734G>A	ENST00000220478.3	+	2	506	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	SCG3_ENST00000542355.2_Intron	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	35					platelet activation|platelet degranulation	extracellular region|stored secretory granule		p.E35K(1)		breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		ACATAATAGAGAATTAAGTGC	0.239000													4	53					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51921498	51921498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51921498C>T	ENST00000371117.3	-	18	1966	c.1691G>A	c.(1690-1692)cGa>cAa	p.R564Q	PKHD1_ENST00000340994.4_Missense_Mutation_p.R564Q	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	564					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GACAGCACCTCGTTCAAATCC	0.408000													39	91					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888235	38888235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38888235C>T	ENST00000302328.3	-	26	5524	c.5326G>A	c.(5326-5328)Gga>Aga	p.G1776R	SCN11A_ENST00000456224.3_Missense_Mutation_p.G1738R|SCN11A_ENST00000450244.1_Missense_Mutation_p.G1776R	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1776					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GACAAGTCTCCATTGCAAAGA	0.532000													34	77					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12184860	12184860	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12184860C>T	ENST00000439326.3	+	2	193	c.18C>T	c.(16-18)ttC>ttT	p.F6F	ZNF844_ENST00000441304.2_Silent_p.F6F	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	6	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TGGTGGCTTTCGAGGATGTGG	0.498000													51	98					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20665616	20665616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20665616C>T	ENST00000357366.3	+	1	122	c.122C>T	c.(121-123)cCc>cTc	p.P41L		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTCAACAGCCCCAGCAACTCC	0.473000													8	47					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27728588	27728588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27728588G>A	ENST00000264717.2	+	10	817	c.754G>A	c.(754-756)Gag>Aag	p.E252K	GCKR_ENST00000424318.2_Missense_Mutation_p.E62K	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	252	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					TCTTCAGCCCGAGGGTCTCAG	0.542000													30	69					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34889177	34889177	+	Splice_Site	SNP	G	G	A	rs149024595		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34889177G>A	ENST00000360581.1	+	9	1154	c.1025_splice	c.e9-1	p.R342_splice	NPSR1_ENST00000359791.1_Intron|NPSR1_ENST00000381539.3_Splice_Site_p.G376_splice|NPSR1_ENST00000381542.1_Splice_Site_p.R276_splice|NPSR1_ENST00000531252.1_Intron	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	342						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity	p.R342R(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CTTTCTCCAGGGAGCAAAGAT	0.408000													27	86					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086445	92086445	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92086445C>T	ENST00000298047.6	+	1	1184	c.1167C>T	c.(1165-1167)tcC>tcT	p.S389S	FAT3_ENST00000525166.1_Silent_p.S239S|FAT3_ENST00000409404.2_Silent_p.S389S|FAT3_ENST00000541502.1_Silent_p.S389S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	389	Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGAATTTTCCCCTCCTGGTG	0.403000										TCGA Ovarian(4;0.039)			11	20					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42145908	42145908	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42145908C>T	ENST00000502486.1	-	3	1170	c.591G>A	c.(589-591)atG>atA	p.M197I	BEND4_ENST00000504360.1_Missense_Mutation_p.M193I	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	197										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						CGCAAGAAATCATGGACTGAG	0.478000													6	17					0	0	1	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545895	234545895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234545895G>A	ENST00000344644.5	+	1	796	c.727G>A	c.(727-729)Gat>Aat	p.D243N	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Missense_Mutation_p.D243N	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		CACGGCATATGATCTCTACAG	0.433000													50	566					0	0	1	0	0
PPM1B	5495	broad.mit.edu	37	2	44429000	44429000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:44429000C>T	ENST00000378551.2	+	2	1074	c.662C>T	c.(661-663)tCt>tTt	p.S221F	PPM1B_ENST00000409895.4_Missense_Mutation_p.S221F|PPM1B_ENST00000282412.4_Missense_Mutation_p.S221F|PPM1B_ENST00000345249.4_Intron|PPM1B_ENST00000378540.4_3'UTR|PPM1B_ENST00000409432.3_Missense_Mutation_p.S221F	NM_177968.2	NP_808907.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	221					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAACTTGTTTCTCCAGAGCCT	0.423000													24	58					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141408673	141408673	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141408673C>T	ENST00000397541.2	+	1	521	c.115C>T	c.(115-117)Caa>Taa	p.Q39*	WEE2-AS1_ENST00000488785.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	39					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					GGCTTCGAGCCAAACCCCAGA	0.468000													57	201					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187205268	187205268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187205268C>T	ENST00000264692.4	+	11	1335	c.1002C>T	c.(1000-1002)ccC>ccT	p.P334P	F11_ENST00000403665.2_Silent_p.P386P			P03951	FA11_HUMAN	coagulation factor XI	386	Apple 4.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	AAATCAAGCCCAGGATCGTTG	0.517000													29	79					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57522853	57522853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57522853G>A	ENST00000420713.1	+	3	353	c.241G>A	c.(241-243)Gag>Aag	p.E81K		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						AAAGAGAAATGAGATGGTAGC	0.408000													32	114					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29429872	29429872	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29429872A>C	ENST00000377136.1	+	4	791	c.326A>C	c.(325-327)gAg>gCg	p.E109A	OR2H1_ENST00000377133.1_Missense_Mutation_p.E109A|OR2H1_ENST00000442615.1_Missense_Mutation_p.E109A|OR2H1_ENST00000396792.2_Missense_Mutation_p.E109A|OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377132.1_Missense_Mutation_p.E109A			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						GGGACCACTGAGTGCATCCTC	0.602000													15	146					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30674574	30674574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30674574G>A	ENST00000534862.1	+	10	1282	c.919G>A	c.(919-921)Gag>Aag	p.E307K	HCK_ENST00000375862.2_Missense_Mutation_p.E326K|HCK_ENST00000518730.1_Missense_Mutation_p.E305K|HCK_ENST00000538448.1_Missense_Mutation_p.E306K|HCK_ENST00000375852.2_Missense_Mutation_p.E327K|HCK_ENST00000520553.1_Missense_Mutation_p.E306K	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	327	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGTCACCAAGGAGCCCATCTA	0.592000													20	54					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86340354	86340354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86340354C>T	ENST00000370571.2	-	35	3482	c.3116G>A	c.(3115-3117)gGa>gAa	p.G1039E	COL24A1_ENST00000436319.1_Missense_Mutation_p.G1039E	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1039	Collagen-like 9.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTCCCCAGTTCCTCCAACACT	0.438000													14	34					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7848085	7848085	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7848085C>T	ENST00000329913.3	-	1	287	c.240G>A	c.(238-240)ggG>ggA	p.G80G		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	80					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						GAAGTACATTCCCGCGGACGC	0.488000													36	65					0	0	1	0	0
CARNS1	57571	broad.mit.edu	37	11	67191785	67191785	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67191785C>T	ENST00000445895.2	+	9	2680	c.2566C>T	c.(2566-2568)Cgt>Tgt	p.R856C	CARNS1_ENST00000531040.1_Missense_Mutation_p.R830C|CARNS1_ENST00000307823.3_Missense_Mutation_p.R733C|CARNS1_ENST00000423745.2_Missense_Mutation_p.R733C			A5YM72	CRNS1_HUMAN	carnosine synthase 1	733					carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)	11						CCCACGTGCTCGTGGCCATCT	0.657000													3	22					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29274634	29274634	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29274634C>T	ENST00000377160.2	+	1	232	c.168C>T	c.(166-168)ccC>ccT	p.P56P		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						TCCATTCCCCCATGTATTACT	0.468000													50	173					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307789	14307789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:14307789C>T	ENST00000378053.3	-	2	620	c.364G>A	c.(364-366)Gat>Aat	p.D122N	FLRT3_ENST00000341420.4_Missense_Mutation_p.D122N|MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	122					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GAAAGTGAATCATAAGTGATA	0.358000													49	118					0	0	1	0	0
USP51	158880	broad.mit.edu	37	X	55513531	55513531	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:55513531G>A	ENST00000500968.3	-	2	1924	c.1842C>T	c.(1840-1842)tcC>tcT	p.S614S	USP51_ENST00000586165.1_5'UTR	NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	614					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						CCAAGGGAAAGGAGATAAAGG	0.433000													7	22					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58134543	58134543	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58134543G>A	ENST00000357272.4	+	36	6220	c.6055G>A	c.(6055-6057)Gag>Aag	p.E2019K	FLNB_ENST00000493452.1_Missense_Mutation_p.E1826K|FLNB_ENST00000490882.1_Missense_Mutation_p.E2050K|FLNB_ENST00000429972.2_Missense_Mutation_p.E2008K|FLNB_ENST00000419752.2_Missense_Mutation_p.E1839K|FLNB_ENST00000348383.5_Missense_Mutation_p.E2019K|FLNB_ENST00000295956.4_Missense_Mutation_p.E2019K|FLNB_ENST00000358537.3_Missense_Mutation_p.E1995K			O75369	FLNB_HUMAN	filamin B, beta	2019	Interaction with the cytoplasmic tail of GP1BA.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCGGACTTTCGAGATGTCTGA	0.597000													23	59					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150883947	150883947	+	Missense_Mutation	SNP	C	C	T	rs104886490	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150883947C>T	ENST00000422024.1	-	1	531	c.406G>A	c.(406-408)Gac>Aac	p.D136N	ASB10_ENST00000420175.2_Missense_Mutation_p.D91N|ASB10_ENST00000377867.3_Intron|ASB10_ENST00000434669.1_Missense_Mutation_p.D136N|ASB10_ENST00000275838.1_Missense_Mutation_p.D91N	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	91					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCTCTGGGTCGCTGGTATCA	0.637000													7	27					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39224351	39224351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39224351C>T	ENST00000333039.2	-	2	914	c.791G>A	c.(790-792)aGg>aAg	p.R264K		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	264						integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					CACTTCCTGCCTCTGCCGGCG	0.652000													22	42					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52698736	52698736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52698736C>T	ENST00000293525.5	+	4	712	c.660C>T	c.(658-660)ctC>ctT	p.L220L	KRT86_ENST00000544024.1_Silent_p.L220L|KRT86_ENST00000423955.2_Silent_p.L220L	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	220	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCGCCTACCTCCGCAAATCAG	0.597000													46	187					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87373272	87373272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:87373272G>A	ENST00000327946.7	-	15	2578	c.2493C>T	c.(2491-2493)ttC>ttT	p.F831F	GRID1_ENST00000536331.1_Silent_p.F402F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	831						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AGACCCCGGCGAAGCTGTGCA	0.652000										Multiple Myeloma(13;0.14)			21	51					0	0	1	0	0
FXYD5	53827	broad.mit.edu	37	19	35660507	35660507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35660507C>T	ENST00000342879.3	+	8	1304	c.526C>T	c.(526-528)Cgt>Tgt	p.R176C	FXYD5_ENST00000588699.1_3'UTR|FXYD5_ENST00000541435.2_Missense_Mutation_p.R176C|FXYD5_ENST00000423817.3_Missense_Mutation_p.R176C|FXYD5_ENST00000392219.2_Missense_Mutation_p.R176C|FXYD5_ENST00000392217.3_Missense_Mutation_p.R105C|FXYD5_ENST00000591716.2_3'UTR|FXYD5_ENST00000590686.1_Missense_Mutation_p.R176C			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	176			R -> H (in dbSNP:rs12110).		microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			ATGCCGGAATCGTTGCAGGTG	0.562000													12	25					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155097	12155097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12155097C>T	ENST00000602107.1	-	5	1259	c.1260G>A	c.(1258-1260)ggG>ggA	p.G420G	CTD-2006C1.2_ENST00000591898.1_RNA|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591838.1_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|ZNF878_ENST00000547628.1_Silent_p.G373G			C9JN71	ZN878_HUMAN	zinc finger protein 878	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TGAAGGTTTTCCCACATTGTT	0.398000													16	60					0	0	1	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378278	31378278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31378278G>A	ENST00000297142.3	-	2	927	c.605C>T	c.(604-606)tCa>tTa	p.S202L		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	202					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						AGAGTAGGGTGACCTTGTGTG	0.557000													19	79					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57372396	57372396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57372396G>A	ENST00000361249.3	+	8	1249	c.1153G>A	c.(1153-1155)Gaa>Aaa	p.E385K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	385	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CATTCAATATGAAGACAAAAT	0.388000													73	124					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71391399	71391399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:71391399C>T	ENST00000392650.3	-	25	3487	c.3487G>A	c.(3487-3489)Gag>Aag	p.E1163K	SDK2_ENST00000388726.3_Missense_Mutation_p.E1163K	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1163	Fibronectin type-III 6.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TCCAGGTCCTCGATGGTGTAG	0.647000													12	26					0	0	1	0	0
SRRM3	222183	broad.mit.edu	37	7	75894779	75894779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:75894779C>T	ENST00000388802.4	+	10	1032	c.823C>T	c.(823-825)Ccc>Tcc	p.P275S	SRRM3_ENST00000464752.1_3'UTR|SRRM3_ENST00000326382.8_Missense_Mutation_p.P275S					serine/arginine repetitive matrix 3											NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)	8						TTCCAGATCTCCCAGCAGGTA	0.632000													15	41					0	0	1	0	0
HCN2	610	broad.mit.edu	37	19	603589	603589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:603589C>T	ENST00000251287.2	+	2	731	c.678C>T	c.(676-678)ctC>ctT	p.L226L		NM_001194.3	NP_001185.3	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	226					cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			endometrium(5)|lung(4)	9		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGAAACCTCATCATCATCC	0.612000													13	28					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401879	89401879	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89401879C>T	ENST00000439576.2	+	12	6437	c.6063C>T	c.(6061-6063)gcC>gcT	p.A2021A	ACAN_ENST00000352105.7_Silent_p.A2021A|ACAN_ENST00000559004.1_Silent_p.A2021A|ACAN_ENST00000561243.1_Silent_p.A2021A	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2021					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCTCTGTAGCCATGGGCACCA	0.502000													30	41					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88769450	88769450	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88769450G>A	ENST00000444431.1	+	0	4050				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GGAGGTGAACGAGACCTGTGG	0.672000													64	130					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018533	161018533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161018533C>T	ENST00000368013.3	-	12	2598	c.2278G>A	c.(2278-2280)Gaa>Aaa	p.E760K	ARHGAP30_ENST00000368016.3_Intron|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.E583K	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	760	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ACCTGGGCTTCCTCTCTTTGT	0.483000													95	243					0	0	1	0	0
ACTR5	79913	broad.mit.edu	37	20	37400247	37400247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:37400247C>T	ENST00000243903.4	+	9	1649	c.1612C>T	c.(1612-1614)Cgt>Tgt	p.R538C		NM_024855.3	NP_079131.3	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog (yeast)	538					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding			kidney(2)|large_intestine(2)|liver(1)|lung(5)|skin(2)	12		Myeloproliferative disorder(115;0.00878)				GTACGGTGCTCGTGACTGGGC	0.507000													30	73					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17412148	17412148	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17412148C>T	ENST00000494857.1	+	8	1353	c.1135C>T	c.(1135-1137)Caa>Taa	p.Q379*	SLC7A2_ENST00000398090.3_Intron|SLC7A2_ENST00000522656.1_Nonsense_Mutation_p.Q379*|SLC7A2_ENST00000470360.1_Intron|SLC7A2_ENST00000004531.10_Nonsense_Mutation_p.Q419*	NM_001008539.3	NP_001008539.3	P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	379					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	ATGTCTAGCTCAAATCAATTC	0.418000													59	171					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57883740	57883740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57883740C>T	ENST00000262027.5	+	5	610	c.476C>T	c.(475-477)cCc>cTc	p.P159L	MARS_ENST00000447721.2_Intron|MARS_ENST00000315473.5_Intron	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	159	GST C-terminal.				methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CTGCAAGATCCCGCCTACCTC	0.473000													48	171					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467458	10467458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10467458C>T	ENST00000382483.3	-	4	4373	c.4150G>A	c.(4150-4152)Gga>Aga	p.G1384R		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1384					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTTGCAGTCCTCCTTCTGGC	0.527000													123	360					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119978560	119978560	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:119978560G>C	ENST00000307142.4	+	5	3453	c.3257G>C	c.(3256-3258)aGt>aCt	p.S1086T	SYNPO2_ENST00000448416.2_Missense_Mutation_p.V88L	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	716						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TTTTAGGAGAGTGGGCGCTCC	0.408000													21	55					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141059121	141059121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141059121G>A	ENST00000239440.4	-	4	754	c.689C>T	c.(688-690)gCt>gTt	p.A230V	ARAP3_ENST00000508305.1_Missense_Mutation_p.A152V	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	230					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CCTGTGTTCAGCCCTGCCCTG	0.537000													21	67					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70960308	70960308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70960308C>T	ENST00000334414.6	-	15	3855	c.3811G>A	c.(3811-3813)Gaa>Aaa	p.E1271K	PTPRB_ENST00000550358.1_Missense_Mutation_p.E1183K|PTPRB_ENST00000551525.1_Missense_Mutation_p.E1270K|PTPRB_ENST00000261266.5_Missense_Mutation_p.E1053K|PTPRB_ENST00000451516.2_Missense_Mutation_p.E963K|PTPRB_ENST00000538708.1_Intron|PTPRB_ENST00000550857.1_Missense_Mutation_p.E963K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1053	Fibronectin type-III 15.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTTAGATCTTCAAATTTGTGT	0.448000													33	30					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	408507	408507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:408507G>A	ENST00000280886.6	-	22	2804	c.2717C>T	c.(2716-2718)tCt>tTt	p.S906F	DIP2C_ENST00000381496.3_3'UTR|DIP2C_ENST00000540204.1_Missense_Mutation_p.S227F	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	906						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGGTGCAGAGAGCCCTCCAG	0.542000													16	88					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531877	42531877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:42531877G>A	ENST00000282030.5	+	4	2868	c.2572G>A	c.(2572-2574)Gag>Aag	p.E858K		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	858						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCCTGTGAGCGAGTCCCACAG	0.572000									Schinzel-Giedion syndrome				13	31					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66811158	66811158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66811158C>T	ENST00000393946.2	+	8	1833	c.671C>T	c.(670-672)cCc>cTc	p.P224L	SYT12_ENST00000527043.1_Missense_Mutation_p.P224L|SYT12_ENST00000525457.1_Missense_Mutation_p.P224L			Q8IV01	SYT12_HUMAN	synaptotagmin XII	224	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						TTCTCCATCCCCCTGGATCCC	0.567000													43	97					0	0	1	0	0
PPP1R32	220004	broad.mit.edu	37	11	61249308	61249308	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61249308C>T	ENST00000338608.2	+	2	152	c.27C>T	c.(25-27)gtC>gtT	p.V9V	PPP1R32_ENST00000432063.2_Silent_p.V9V|RP11-286N22.8_ENST00000543044.1_3'UTR|RP11-286N22.8_ENST00000544880.1_Intron	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	9																	CCCTGGGGGTCGTCTCCCCTT	0.637000													5	30					0	0	1	0	0
INSIG1	3638	broad.mit.edu	37	7	155094485	155094485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:155094485C>T	ENST00000340368.4	+	5	944	c.733C>T	c.(733-735)Cgt>Tgt	p.R245C	INSIG1_ENST00000344756.4_Missense_Mutation_p.R93C|INSIG1_ENST00000342407.5_Silent_p.F147F	NM_005542.4	NP_005533.2	O15503	INSI1_HUMAN	insulin induced gene 1	245					cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	19	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCTATATTCGTTCTTGGCT	0.418000													58	112					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87018049	87018049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:87018049G>A	ENST00000398399.2	-	3	991	c.628C>T	c.(628-630)Cct>Tct	p.P210S	VGLL3_ENST00000383698.3_Missense_Mutation_p.P210S	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GATGTCAAAGGATAAGGCCAG	0.602000													21	123					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82034431	82034431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:82034431G>A	ENST00000328945.5	-	2	160	c.33C>T	c.(31-33)gtC>gtT	p.V11V	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	11					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CTGTAATGAGGACACTTTCCT	0.378000													15	54					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164371	150164371	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150164371G>A	ENST00000307271.3	+	2	1159	c.585G>A	c.(583-585)acG>acA	p.T195T		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	195						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TGGTGAATACGAACGGAGGAC	0.423000													49	92					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77442766	77442766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77442766C>T	ENST00000451710.3	-	7	1006	c.769G>A	c.(769-771)Ggc>Agc	p.G257S	TRPM6_ENST00000376864.4_Missense_Mutation_p.G257S|TRPM6_ENST00000361255.3_Missense_Mutation_p.G252S|TRPM6_ENST00000360774.1_Missense_Mutation_p.G257S|TRPM6_ENST00000376871.3_Missense_Mutation_p.G257S|TRPM6_ENST00000376872.3_Missense_Mutation_p.G257S|TRPM6_ENST00000449912.2_Missense_Mutation_p.G252S|TRPM6_ENST00000359047.2_Missense_Mutation_p.G257S|TRPM6_ENST00000483186.1_5'UTR			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	257					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CCATACTTGCCCACGGTCCCA	0.517000													10	89					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209799047	209799047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209799047G>A	ENST00000391911.1	-	13	2311	c.1922C>T	c.(1921-1923)cCc>cTc	p.P641L	LAMB3_ENST00000356082.4_Missense_Mutation_p.P641L|LAMB3_ENST00000367030.3_Missense_Mutation_p.P641L	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	641	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TGTGACTGCGGGGCTGCTGAG	0.587000													32	85					0	0	1	0	0
ESRRA	2101	broad.mit.edu	37	11	64074765	64074765	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64074765C>T	ENST00000405666.1	+	2	348	c.114C>T	c.(112-114)gcC>gcT	p.A38A	ESRRA_ENST00000000442.6_Silent_p.A38A|ESRRA_ENST00000406310.1_Silent_p.A38A			P11474	ERR1_HUMAN	estrogen-related receptor alpha	38	Repressor domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14						TGGCCCTGGCCCCTGGTCCAG	0.667000													14	30					0	0	1	0	0
WDR77	79084	broad.mit.edu	37	1	111983920	111983920	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111983920G>A	ENST00000235090.5	-	10	1167	c.961C>T	c.(961-963)Cag>Tag	p.Q321*	WDR77_ENST00000497278.1_5'UTR|WDR77_ENST00000411751.2_Nonsense_Mutation_p.Q257*	NM_024102.2	NP_077007.1	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	321				LTTVGWDHQVVHHVVPTEPLPAPGPASVTE -> DLQVLLS RLDLRQKASPP (in Ref. 7; AAH09411).	ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGGACGACCTGATGGTCCCAG	0.527000													39	81					0	0	1	0	0
RARB	5915	broad.mit.edu	37	3	25216031	25216031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:25216031C>T	ENST00000404969.1	+	1	143	c.143C>T	c.(142-144)cCg>cTg	p.P48L				P10826	RARB_HUMAN	retinoic acid receptor, beta	48	Modulating.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|kidney(1)|large_intestine(10)|lung(11)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	28					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	CATGGACATCCGCCTCCGAGT	0.557000													23	68					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21225122	21225122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21225122G>A	ENST00000233242.1	-	29	13299	c.13172C>T	c.(13171-13173)cCa>cTa	p.P4391L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4391					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACTATACTTGGATCAAAATA	0.363000													33	69					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38616851	38616851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38616851G>A	ENST00000413689.1	-	20	3796	c.3603C>T	c.(3601-3603)atC>atT	p.I1201I	SCN5A_ENST00000423572.2_Silent_p.I1200I|SCN5A_ENST00000425664.1_Silent_p.I1201I|SCN5A_ENST00000333535.4_Silent_p.I1201I|SCN5A_ENST00000451551.2_Silent_p.I1147I|SCN5A_ENST00000455624.2_Silent_p.I1200I|SCN5A_ENST00000449557.2_Silent_p.I1147I|SCN5A_ENST00000450102.2_Silent_p.I1147I|SCN5A_ENST00000443581.1_Silent_p.I1200I|SCN5A_ENST00000414099.2_Silent_p.I1201I	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1201					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGTGCTCCACGATGTGGTAGC	0.617000													9	16					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68873164	68873164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:68873164G>A	ENST00000303786.3	+	2	631	c.211G>A	c.(211-213)Ggc>Agc	p.G71S	PROKR1_ENST00000394342.2_Missense_Mutation_p.G71S			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	71						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GGCCCTGGTGGGCATCATGCT	0.517000													19	187					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66084128	66084128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66084128C>T	ENST00000311330.3	-	1	387	c.371G>A	c.(370-372)gGc>gAc	p.G124D	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	124	C-type lectin.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	CGGGCAGGGGCCTCCAGAGGC	0.711000													13	29					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103654	53103654	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:53103654G>A	ENST00000408890.4	+	1	306	c.290G>A	c.(289-291)tGg>tAg	p.W97*		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	97										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						TCCGAGGGCTGGAGGCGCCCT	0.711000													14	22					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730673	96730673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96730673C>T	ENST00000216629.6	+	3	1260	c.654C>T	c.(652-654)atC>atT	p.I218I	BDKRB1_ENST00000553356.1_Silent_p.I218I|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	218					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TGGCTGCGATCGTCTTCTTCA	0.582000													14	48					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48157768	48157768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48157768C>T	ENST00000418331.2	+	9	2145	c.1793C>T	c.(1792-1794)cCg>cTg	p.P598L		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	598	Fibronectin type-III 6.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GGCCTGATTCCGGGCACCTTA	0.512000													32	42					0	0	1	0	0
RABL2A	11159	broad.mit.edu	37	2	114398531	114398531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:114398531C>T	ENST00000409875.1	+	7	660	c.358C>T	c.(358-360)Cgg>Tgg	p.R120W	RABL2A_ENST00000409842.1_Intron|RABL2A_ENST00000393165.3_Missense_Mutation_p.R120W|RABL2A_ENST00000393166.3_Missense_Mutation_p.R120W|RABL2A_ENST00000393167.3_Missense_Mutation_p.R120W|RABL2A_ENST00000478880.1_3'UTR|RABL2A_ENST00000376439.3_Intron			Q9UBK7	RBL2A_HUMAN	RAB, member of RAS oncogene family-like 2A	120					small GTPase mediated signal transduction		GTP binding|GTPase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|stomach(3)	9						TACAGAGCTTCGGGAGTTCAG	0.512000													22	55					0	0	1	0	0
CCDC116	164592	broad.mit.edu	37	22	21989023	21989023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21989023C>T	ENST00000292779.3	+	4	832	c.671C>T	c.(670-672)tCg>tTg	p.S224L		NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	224										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					CTGTGGGATTCGCTGGGTAGC	0.597000													93	227					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65464345	65464345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:65464345C>T	ENST00000330909.8	-	4	678	c.679G>A	c.(679-681)Gat>Aat	p.D227N	MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000402939.2_Missense_Mutation_p.D227N|MAGI1_ENST00000483466.1_Missense_Mutation_p.D227N|MAGI1_ENST00000497477.2_Missense_Mutation_p.D227N	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	227	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TTTTGCATATCATTGTAGGAC	0.512000													31	123					0	0	1	0	0
KIAA1468	57614	broad.mit.edu	37	18	59947646	59947646	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:59947646C>T	ENST00000398130.2	+	23	3253	c.3021C>T	c.(3019-3021)gcC>gcT	p.A1007A	KIAA1468_ENST00000256858.6_Intron	NM_020854.3	NP_065905.2	Q9P260	K1468_HUMAN	KIAA1468	1007							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				TTGCTCCGGCCCTTGTTACCT	0.438000													27	133					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233807177	233807177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233807177C>T	ENST00000366621.3	+	3	1080	c.912C>T	c.(910-912)atC>atT	p.I304I	KCNK1_ENST00000472190.1_3'UTR|KCNK1_ENST00000366620.1_Silent_p.I188I	NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	304						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TCTCCTCGATCACAGACCAGG	0.488000													8	66					0	0	1	0	0
SYPL2	284612	broad.mit.edu	37	1	110018223	110018223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110018223C>T	ENST00000369872.3	+	3	366	c.150C>T	c.(148-150)ttC>ttT	p.F50F	SYPL2_ENST00000475497.1_3'UTR|SYPL2_ENST00000401021.3_Silent_p.F50F	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	50	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		TTTTCGCCTTCGGGTCCTGTG	0.547000													13	64					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66479639	66479639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:66479639G>A	ENST00000256447.4	-	3	1189	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	344					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TAAGGGAGGGGAAATTGGCAG	0.433000													56	142					0	0	1	0	0
TDP1	55775	broad.mit.edu	37	14	90509483	90509483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90509483C>T	ENST00000335725.4	+	17	2073	c.1823C>T	c.(1822-1824)tCc>tTc	p.S608F	TDP1_ENST00000555880.1_Missense_Mutation_p.P572S|TDP1_ENST00000393454.2_Missense_Mutation_p.S608F|TDP1_ENST00000393452.3_3'UTR|TDP1_ENST00000357382.3_Missense_Mutation_p.S369F	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	608					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGGTGCCCTCCTGAGAATCT	0.423000								Repair of DNA-protein crosslinks					17	49					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52884373	52884373	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52884373C>T	ENST00000330722.6	-	5	1125	c.1057G>A	c.(1057-1059)Gag>Aag	p.E353K		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	353	Coil 2.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		TACCAGGACTCAGCCTCAGCC	0.577000													91	174					0	0	1	0	0
UGT1A7	54577	broad.mit.edu	37	2	234590866	234590866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234590866G>A	ENST00000373426.3	+	1	283	c.283G>A	c.(283-285)Gat>Aat	p.D95N	UGT1A10_ENST00000344644.5_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Intron	NM_019077.2	NP_061950.2														NS(1)|endometrium(6)|kidney(5)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|prostate(1)|skin(1)	33		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGTTTTTGCCGATGCTCGCTG	0.433000													61	142					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57406576	57406576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57406576C>T	ENST00000543257.1	-	10	1754	c.1188G>A	c.(1186-1188)ctG>ctA	p.L396L	C8B_ENST00000371237.4_Silent_p.L448L|C8B_ENST00000535057.1_Silent_p.L386L	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	448	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ACTCCTGCATCAGGTCCGCCG	0.572000													22	71					0	0	1	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899267	112899267	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112899267C>T	ENST00000374530.3	+	8	1623	c.1443C>T	c.(1441-1443)atC>atT	p.I481I	PALM2-AKAP2_ENST00000302798.7_Silent_p.I481I|AKAP2_ENST00000259318.7_Silent_p.I250I|AKAP2_ENST00000555236.1_Silent_p.I481I|AKAP2_ENST00000374525.1_Silent_p.I339I|AKAP2_ENST00000510514.5_Silent_p.I481I|AKAP2_ENST00000434623.2_Silent_p.I339I	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		250							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						AAAAAACCATCGAGGAGCAGC	0.537000													15	40					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24810379	24810379	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24810379C>T	ENST00000221169.5	-	0	2171							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		ttcttctcctcctcttcagct	0.413000													22	65					0	0	1	0	0
LRRN4	164312	broad.mit.edu	37	20	6022130	6022130	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6022130C>T	ENST00000378858.4	-	5	1985	c.1761G>A	c.(1759-1761)ggG>ggA	p.G587G		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	587	Fibronectin type-III.					integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						TCTCCGTCACCCCCTGCAGCC	0.711000													28	60					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115526413	115526413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115526413G>A	ENST00000361048.1	+	4	487	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	PLEKHS1_ENST00000369312.4_5'UTR|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.E48K	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		AAAGGCTGGGGAAAAGAGCTT	0.338000													42	80					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10615137	10615137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:10615137G>A	ENST00000547195.1	-	16	2304	c.1804C>T	c.(1804-1806)Cgc>Tgc	p.R602C	LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000541483.1_Missense_Mutation_p.R487C|MRVI1_ENST00000421747.1_Missense_Mutation_p.R684C|MRVI1_ENST00000423302.2_Missense_Mutation_p.R693C|MRVI1_ENST00000436272.1_Missense_Mutation_p.R666C|MRVI1_ENST00000534266.2_Missense_Mutation_p.R378C|MRVI1-AS1_ENST00000529979.1_RNA|MRVI1_ENST00000424001.1_Missense_Mutation_p.R378C|MRVI1_ENST00000531107.1_Missense_Mutation_p.R685C|MRVI1_ENST00000527509.2_Missense_Mutation_p.R602C|MRVI1-AS1_ENST00000525578.1_RNA|MRVI1_ENST00000558540.1_Missense_Mutation_p.R378C|MRVI1_ENST00000552103.1_Missense_Mutation_p.R602C|MRVI1-AS1_ENST00000529829.1_RNA|MRVI1_ENST00000545852.1_Missense_Mutation_p.R378C	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	666					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		ACCCTCCGGCGAGGCATATTC	0.512000													13	40					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43246125	43246125	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43246125G>A	ENST00000255226.6	+	12	2314	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K	SLC14A2_ENST00000586448.1_Missense_Mutation_p.E500K|SLC14A2_ENST00000589658.1_5'UTR	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	500						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CGAACACCAGGAAAGACAAAA	0.507000											OREG0024946	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	86					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4834032	4834032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4834032C>T	ENST00000268231.8	-	5	675	c.412G>A	c.(412-414)Gag>Aag	p.E138K	SEPT12_ENST00000396693.5_Intron	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	138					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						AGGTACTGCTCGTATTGCTCG	0.632000													14	150					0	0	1	0	0
MDH1B	130752	broad.mit.edu	37	2	207620226	207620226	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207620226G>A	ENST00000374412.3	-	5	692	c.417C>T	c.(415-417)gcC>gcT	p.A139A	MDH1B_ENST00000449792.1_Silent_p.A41A|MDH1B_ENST00000454776.2_Silent_p.A139A|MDH1B_ENST00000392214.2_Intron	NM_001039845.1	NP_001034934.1	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	139					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(14)|ovary(4)|stomach(1)	34				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		CAGGAGCAGAGGCACTGATAA	0.398000													22	70					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954982	70954982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70954982G>A	ENST00000393567.2	-	46	7447	c.7297C>T	c.(7297-7299)Cct>Tct	p.P2433S		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2433										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TGGACAAGAGGAAGCCCATGC	0.458000													31	126					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201358367	201358367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201358367G>A	ENST00000391967.2	-	2	404	c.103C>T	c.(103-105)Cgc>Tgc	p.R35C	LAD1_ENST00000367313.3_Missense_Mutation_p.R49C	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	35	Poly-Arg.					basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						CTCAGGTTGCGGTGCCGCCGC	0.657000													19	44					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62253103	62253103	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:62253103A>G	ENST00000474889.1	+	18	3052	c.2675A>G	c.(2674-2676)aAg>aGg	p.K892R	PTPRG-AS1_ENST00000462497.1_RNA|PTPRG_ENST00000295874.10_Missense_Mutation_p.K863R|PTPRG-AS1_ENST00000495542.1_RNA|PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000475371.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	892	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		AGTAGGGTGAAGTTAAGACCT	0.333000													42	111					0	0	1	0	0
RGS5	8490	broad.mit.edu	37	1	163117238	163117238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:163117238G>A	ENST00000313961.5	-	5	717	c.440C>T	c.(439-441)tCc>tTc	p.S147F	RGS5_ENST00000527988.1_Missense_Mutation_p.S39F|RGS5_ENST00000367903.3_Missense_Mutation_p.S167F|RGS5_ENST00000530507.1_Missense_Mutation_p.S151F	NM_001254749.1|NM_003617.3	NP_001241678.1|NP_003608.1	O15539	RGS5_HUMAN	regulator of G-protein signaling 5	147	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20			LUSC - Lung squamous cell carcinoma(543;0.187)			GCTGCTCAGGGAAGGTTCCAC	0.463000													30	82					0	0	1	0	0
GABRQ	55879	broad.mit.edu	37	X	151818293	151818293	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151818293C>T	ENST00000370306.2	+	6	719	c.699C>T	c.(697-699)ttC>ttT	p.F233F		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	233						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCTCAGTTCACTTTCCTGG	0.498000													36	50					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85446507	85446507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:85446507C>T	ENST00000369663.5	-	8	2057	c.1720G>A	c.(1720-1722)Gga>Aga	p.G574R	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	574					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AGGTGCACTCCTTCCACAGGG	0.517000													22	26					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27997849	27997849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27997849C>T	ENST00000441525.1	-	1	1717	c.1603G>A	c.(1603-1605)Gac>Aac	p.D535N		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	535										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						TTCAAGTTGTCTTCATCTCGC	0.483000													43	23					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50744591	50744591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50744591C>T	ENST00000300589.2	+	4	874	c.769C>T	c.(769-771)Ctg>Ttg	p.L257L	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	257					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				AGAGAATGTCCTGGAGGTCTG	0.607000													6	33					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192545472	192545472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:192545472G>A	ENST00000367459.3	+	2	261	c.195G>A	c.(193-195)atG>atA	p.M65I	RGS1_ENST00000469578.2_Missense_Mutation_p.M65I	NM_002922.3	NP_002913.3	Q08116	RGS1_HUMAN	regulator of G-protein signaling 1	65					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			kidney(8)|large_intestine(1)|lung(13)	22		Breast(1374;0.188)				AATCTGGAATGAAATCTTCCA	0.343000													24	49					0	0	1	0	0
HOMEZ	57594	broad.mit.edu	37	14	23746205	23746205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23746205G>A	ENST00000357460.5	-	2	396	c.232C>T	c.(232-234)Ccc>Tcc	p.P78S	HOMEZ_ENST00000431326.2_Missense_Mutation_p.P80S|HOMEZ_ENST00000561013.1_Missense_Mutation_p.P80S	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	78						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CTGGGATAGGGAAAGTAGCTG	0.537000													9	126					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588440	93588440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:93588440C>T	ENST00000329082.7	-	4	1412	c.1141G>A	c.(1141-1143)Gac>Aac	p.D381N	RGMA_ENST00000543599.1_Missense_Mutation_p.D365N|RGMA_ENST00000538818.1_Missense_Mutation_p.D272N|RGMA_ENST00000557420.1_3'UTR|RGMA_ENST00000425933.2_Missense_Mutation_p.D365N|RGMA_ENST00000557301.1_Missense_Mutation_p.D389N|RGMA_ENST00000556658.1_Missense_Mutation_p.D272N|RGMA_ENST00000542321.2_Missense_Mutation_p.D365N	NM_020211.2	NP_064596.2	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	381					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GTGAGGAGGTCGAAGACGCAG	0.592000													3	22					0	0	1	0	0
ZNF248	57209	broad.mit.edu	37	10	38121119	38121119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:38121119G>A	ENST00000395867.3	-	6	1714	c.1164C>T	c.(1162-1164)acC>acT	p.T388T	ZNF248_ENST00000374648.3_Intron|ZNF248_ENST00000357328.4_Silent_p.T388T|ZNF248_ENST00000494133.1_Intron	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						TCTCCCAGAAGGTTTTCCCAC	0.443000													32	140					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40368832	40368832	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40368832C>T	ENST00000221347.6	-	28	12523	c.12516G>A	c.(12514-12516)ggG>ggA	p.G4172G		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4172	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTGAAATCCGCCCGTCGGCCA	0.617000													38	225					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140221334	140221334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140221334C>T	ENST00000531613.1	+	1	428	c.428C>T	c.(427-429)tCa>tTa	p.S143L	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.S143L|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTTTGTTTCAGAATCCAGA	0.517000													49	113					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28548732	28548732	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:28548732C>T	ENST00000401766.2	-	2	757	c.245G>A	c.(244-246)tGg>tAg	p.W82*	SLC6A4_ENST00000261707.3_Nonsense_Mutation_p.W82*			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	82					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CTTCTTGCCCCAGGTCTCCCG	0.567000													51	61					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7373425	7373425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7373425C>T	ENST00000502583.1	-	5	2191	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	CAGE1_ENST00000338150.4_Missense_Mutation_p.E543K|CAGE1_ENST00000379918.4_Missense_Mutation_p.E543K|CAGE1_ENST00000296742.7_Missense_Mutation_p.E407K|CAGE1_ENST00000512086.1_Missense_Mutation_p.E543K	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	543										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					TTTGCATTCTCATTTTTTACT	0.333000													4	45					0	0	1	0	0
RAB40AL	282808	broad.mit.edu	37	X	102193023	102193023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:102193023C>T	ENST00000218249.5	+	1	824	c.777C>T	c.(775-777)atC>atT	p.I259I	LL0XNC01-237H1.3_ENST00000413528.1_RNA	NM_001031834.1	NP_001027004.1	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	259					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(3)	12						AAGTGAAGATCGTCTGCCCAC	0.537000													47	39					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123333775	123333775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123333775G>A	ENST00000296513.2	+	10	1245	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	ADAD1_ENST00000388725.2_Missense_Mutation_p.E336K|ADAD1_ENST00000388724.2_Missense_Mutation_p.E343K	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	354	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGAAGCCAATGAAGAACTCTG	0.358000													17	175					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38531036	38531036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38531036G>A	ENST00000332509.3	-	6	1036	c.853C>T	c.(853-855)Cgt>Tgt	p.R285C	PLA2G6_ENST00000335539.3_Missense_Mutation_p.R285C|PLA2G6_ENST00000402064.1_Missense_Mutation_p.R285C	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	285					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	GCTCCGTAACGGGGGTCTTTG	0.657000													20	59					0	0	1	0	0
PHB	5245	broad.mit.edu	37	17	47482519	47482519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47482519G>A	ENST00000300408.3	-	7	726	c.654C>T	c.(652-654)tcC>tcT	p.S218S	RP11-81K2.1_ENST00000576461.1_Intron|RP11-1079K10.4_ENST00000506504.3_RNA|PHB_ENST00000511832.1_Intron	NM_002634.2	NP_002625.1	P35232	PHB_HUMAN	prohibitin	218					cellular response to interleukin-6|DNA replication|glucocorticoid receptor signaling pathway|histone deacetylation|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|progesterone receptor signaling pathway|regulation of apoptosis	integral to plasma membrane|mitochondrial inner membrane|nucleoplasm	histone deacetylase binding|transcription regulatory region DNA binding			endometrium(4)|large_intestine(2)|lung(4)	10	all_cancers(4;2.62e-14)|Breast(4;4.21e-29)|all_epithelial(4;6.9e-18)		Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)			CAGCTGCCTTGGAGTCGCCCT	0.567000													4	29					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129781995	129781995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:129781995G>A	ENST00000358825.5	-	19	3210	c.2979C>T	c.(2977-2979)gcC>gcT	p.A993A	PRDM10_ENST00000423662.2_Intron|PRDM10_ENST00000304538.6_Intron|PRDM10_ENST00000528746.1_Intron|PRDM10_ENST00000526082.1_Silent_p.A907A|PRDM10_ENST00000360871.3_Silent_p.A989A	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	984	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CGGAGGACGGGGCCGAGGCGG	0.572000													37	117					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269998	150269998	+	Silent	SNP	G	G	A	rs77995447		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150269998G>A	ENST00000255945.2	+	3	1015	c.840G>A	c.(838-840)gaG>gaA	p.E280E	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Silent_p.E294E	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	280							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAAATGGAGAAGAAACTAG	0.443000													22	50					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13381784	13381784	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13381784G>A	ENST00000254508.5	-	24	3325	c.3243C>T	c.(3241-3243)ttC>ttT	p.F1081F	NUP210_ENST00000485755.1_Intron	NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1081					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GCATCAGCCTGAACGGGGGAA	0.577000													8	42					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125148802	125148802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125148802G>A	ENST00000362012.2	+	9	1092	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K	PTGS1_ENST00000223423.4_Missense_Mutation_p.E363K|PTGS1_ENST00000540753.1_Missense_Mutation_p.E338K|AL162424.1_ENST00000600713.1_Intron|PTGS1_ENST00000373698.5_Missense_Mutation_p.E254K	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	363					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATTTGACCCAGAGCTGCTGTT	0.537000													40	142					0	0	1	0	0
PRKG1	5592	broad.mit.edu	37	10	54040554	54040554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:54040554C>T	ENST00000373980.4	+	13	1826	c.1409C>T	c.(1408-1410)tCg>tTg	p.S470L	PRKG1_ENST00000401604.2_Missense_Mutation_p.S455L|PRKG1_ENST00000373975.2_Missense_Mutation_p.S173L|PRKG1-AS1_ENST00000426785.2_RNA|PRKG1_ENST00000373985.1_Missense_Mutation_p.S443L|PRKG1-AS1_ENST00000452247.2_RNA	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	455	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		CTCAGAGGTTCGTTTGAAGAT	0.343000													25	84					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71444949	71444949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:71444949C>T	ENST00000304743.2	+	6	2341	c.1895C>T	c.(1894-1896)tCc>tTc	p.S632F	PCNX_ENST00000439984.3_Missense_Mutation_p.S632F|PCNX_ENST00000238570.5_Missense_Mutation_p.S632F	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	632	Ser-rich.					integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ACTTCTCATTCCTGTCAGTCT	0.463000													19	88					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2940692	2940692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:2940692G>A	ENST00000261596.4	-	5	847	c.609C>T	c.(607-609)tcC>tcT	p.S203S		NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	203					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CTTCTTTCAAGGAAGCATTTG	0.413000													14	38					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111551725	111551725	+	Missense_Mutation	SNP	G	G	A	rs150003283	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:111551725G>A	ENST00000389811.4	+	5	543	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K	ACOXL_ENST00000439055.1_Missense_Mutation_p.E107K|ACOXL_ENST00000340561.4_Missense_Mutation_p.E107K			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	107					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						GATCCAGACCGAAGCCACCTT	0.537000													14	62					0	0	1	0	0
SAMD3	154075	broad.mit.edu	37	6	130505248	130505248	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:130505248G>A	ENST00000532763.1	-	6	777	c.648_splice	c.e6+1	p.F216_splice	SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000439090.2_Splice_Site_p.F218_splice|SAMD3_ENST00000437477.2_Splice_Site_p.F218_splice|SAMD3_ENST00000457563.2_Splice_Site_p.F242_splice|SAMD3_ENST00000368134.2_Splice_Site_p.F218_splice|SAMD3_ENST00000324172.6_Splice_Site_p.F218_splice			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	218										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		GGTCACTTACGAAGCCACAGC	0.468000													10	13					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23816229	23816229	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:23816229C>T	ENST00000264867.2	-	8	997		c.e8-1		PPARGC1A_ENST00000509702.1_Splice_Site	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha						androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GGAGTTAGGCCTAAGGCAAAA	0.393000													17	39					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53295761	53295761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53295761G>A	ENST00000552551.1	-	3	852	c.420C>T	c.(418-420)ttC>ttT	p.F140F	KRT8_ENST00000546897.1_Silent_p.F140F|KRT8_ENST00000293308.6_Silent_p.F140F|KRT8_ENST00000552150.1_Silent_p.F168F			P05787	K2C8_HUMAN	keratin 8	140	Linker 1.|Rod.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTAGCTCTCGAACATGTTGT	0.572000													16	63					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53907746	53907746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:53907746C>T	ENST00000396328.1	-	15	2896	c.2657G>A	c.(2656-2658)aGa>aAa	p.R886K	WDR72_ENST00000360509.5_Missense_Mutation_p.R886K|WDR72_ENST00000559418.1_Missense_Mutation_p.R896K|WDR72_ENST00000557913.1_Missense_Mutation_p.R883K	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	886										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTCCAATCCTCTTGGAATTCC	0.313000													13	69					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2182194	2182194	+	Silent	SNP	C	C	T	rs1803766		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:2182194C>T	ENST00000382203.1	+	31	4622	c.4413C>T	c.(4411-4413)gtC>gtT	p.V1471V	SMARCA2_ENST00000382194.1_Silent_p.V1453V|SMARCA2_ENST00000349721.2_Silent_p.V1471V|SMARCA2_ENST00000382186.1_Silent_p.V135V|SMARCA2_ENST00000357248.2_Silent_p.V1453V|SMARCA2_ENST00000382185.1_Silent_p.V117V|SMARCA2_ENST00000302401.3_Silent_p.V159V|SMARCA2_ENST00000324954.5_Silent_p.V117V			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1471	Bromo.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AGAAGGATGTCATGCTTCTCT	0.443000													16	133					0	0	1	0	0
LOC344967	344967	broad.mit.edu	37	4	40045554	40045554	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40045554G>A	ENST00000381811.2	-	0	595					NR_027277.1																						TGGGCCACAGGAAGTGGGTGC	0.612000													4	10					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201029892	201029892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201029892G>A	ENST00000362061.3	-	26	3534	c.3308C>T	c.(3307-3309)cCc>cTc	p.P1103L	CACNA1S_ENST00000367338.3_Missense_Mutation_p.P1103L	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1103					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGGGTTTTTGGGAATGTAGCA	0.537000													18	277					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5489039	5489039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:5489039G>A	ENST00000341928.2	-	2	484	c.144C>T	c.(142-144)ttC>ttT	p.F48F	EPB41L3_ENST00000540638.2_Silent_p.F48F|EPB41L3_ENST00000342933.3_Silent_p.F48F|EPB41L3_ENST00000544123.1_Silent_p.F48F|EPB41L3_ENST00000400111.3_Silent_p.F48F	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	48					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						CAGCGGCGGCGAACTGCTCCA	0.721000													10	30					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389397	4389397	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4389397C>T	ENST00000408920.2	-	1	219	c.129G>A	c.(127-129)ggG>ggA	p.G43G		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCAGGCTGTTCCCAAGAAGGG	0.527000													11	29					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166172174	166172174	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166172174C>T	ENST00000357398.3	+	11	1867	c.1577C>T	c.(1576-1578)tCg>tTg	p.S526L	SCN2A_ENST00000375437.2_Missense_Mutation_p.S526L|SCN2A_ENST00000375427.2_Missense_Mutation_p.S526L|SCN2A_ENST00000283256.6_Missense_Mutation_p.S526L			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	526					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTCCGAAAATCGGAATCTGAA	0.373000													32	89					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585815	179585815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179585815C>T	ENST00000589042.1	-	79	23155	c.22931G>A	c.(22930-22932)cGa>cAa	p.R7644Q	TTN_ENST00000342992.6_Missense_Mutation_p.R6400Q|TTN_ENST00000591111.1_Missense_Mutation_p.R7327Q|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7327	Ig-like 58.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTCATTTCGGAACCATGA	0.393000													22	92					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128928849	128928849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128928849C>T	ENST00000375990.3	+	28	3426	c.3023C>T	c.(3022-3024)cCt>cTt	p.P1008L	UGGT1_ENST00000259253.6_Missense_Mutation_p.P1032L			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	1032					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TCTGACATGCCTTTAAAAAGG	0.338000													13	40					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64056769	64056769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64056769C>T	ENST00000411458.1	+	9	1388	c.1360C>T	c.(1360-1362)Cgt>Tgt	p.R454C	GPR137_ENST00000539851.1_3'UTR|GPR137_ENST00000438980.2_3'UTR|GPR137_ENST00000377702.4_3'UTR|GPR137_ENST00000313074.3_Missense_Mutation_p.R396C	NM_001170726.1	NP_001164197.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	396						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						TCCTGGGGGTCGTGGCTACCC	0.667000													64	149					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277022	152277022	+	Missense_Mutation	SNP	C	C	T	rs138147945	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152277022C>T	ENST00000368799.1	-	3	10375	c.10340G>A	c.(10339-10341)gGa>gAa	p.G3447E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3447	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTAGTGGGATCCCTGCCTTCC	0.607000									Ichthyosis				177	398					0	0	1	0	0
FAM86B1	85002	broad.mit.edu	37	8	12042898	12042898	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:12042898G>A	ENST00000448228.2	-	6	826	c.777C>T	c.(775-777)ttC>ttT	p.F259F	FAM86B1_ENST00000321602.8_Silent_p.F65F|FAM86B1_ENST00000534520.1_3'UTR|FAM86B1_ENST00000533852.2_Silent_p.F293F	NM_001083537.1	NP_001077006.1	Q8N7N1	F86B1_HUMAN	family with sequence similarity 86, member B1	259										kidney(1)|prostate(1)|stomach(1)	3			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		GCTCGGTGGTGAACAGCTGGC	0.662000													9	23					0	0	1	0	0
SLC12A4	6560	broad.mit.edu	37	16	67997414	67997414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67997414G>A	ENST00000316341.3	-	2	304	c.164C>T	c.(163-165)gCt>gTt	p.A55V	SLC12A4_ENST00000422611.2_Intron|SLC12A4_ENST00000576616.1_Missense_Mutation_p.A55V|SLC12A4_ENST00000338335.3_Missense_Mutation_p.A55V|SLC12A4_ENST00000541864.2_Missense_Mutation_p.A24V|SLC12A4_ENST00000572010.1_5'UTR|SLC12A4_ENST00000537830.2_Missense_Mutation_p.A49V|SLC12A4_ENST00000572037.1_Intron	NM_001145961.1|NM_005072.4	NP_001139433.1|NP_005063.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	55					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCTCTGGAAGCCTCCAAGGG	0.547000													5	74					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216595616	216595616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216595616G>A	ENST00000366943.2	-	2	449	c.63C>T	c.(61-63)atC>atT	p.I21I	USH2A_ENST00000366942.3_Silent_p.I21I|USH2A_ENST00000307340.3_Silent_p.I21I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	21					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AATAGGCAAAGATCAACATTT	0.428000										HNSCC(13;0.011)			27	72					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161318012	161318012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:161318012C>T	ENST00000428797.2	+	9	1167	c.812C>T	c.(811-813)tCc>tTc	p.S271F	GABRA1_ENST00000023897.6_Missense_Mutation_p.S271F|GABRA1_ENST00000437025.2_Missense_Mutation_p.S271F|GABRA1_ENST00000420560.1_Missense_Mutation_p.S271F|GABRA1_ENST00000444819.1_Missense_Mutation_p.S271F|GABRA1_ENST00000393943.4_Missense_Mutation_p.S271F	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	271					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TCACAAGTCTCCTTCTGGCTC	0.413000													20	80					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140258001	140258001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:140258001G>A	ENST00000275884.6	-	10	2318	c.1901C>T	c.(1900-1902)tCa>tTa	p.S634L	DENND2A_ENST00000496613.1_Missense_Mutation_p.S634L|DENND2A_ENST00000492720.1_Missense_Mutation_p.S634L|DENND2A_ENST00000537639.1_Missense_Mutation_p.S634L			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	634	UDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					TAAGACAAATGAGAATGTTTC	0.473000													18	47					0	0	1	0	0
NFS1	9054	broad.mit.edu	37	20	34278402	34278402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34278402G>A	ENST00000374092.4	-	5	564	c.494C>T	c.(493-495)tCa>tTa	p.S165L	NFS1_ENST00000374085.1_Missense_Mutation_p.S105L|NFS1_ENST00000541387.1_Intron|NFS1_ENST00000540053.1_5'UTR|NFS1_ENST00000397425.1_Missense_Mutation_p.S105L	NM_021100.4	NP_066923.3	Q9Y697	NFS1_HUMAN	NFS1 cysteine desulfurase	165					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	18	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	AGCTTCCAGTGAACGGCAGGA	0.512000													96	201					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130383928	130383928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130383928G>A	ENST00000358511.6	+	35	6615	c.6584G>A	c.(6583-6585)cGa>cAa	p.R2195Q	COL6A6_ENST00000453409.2_Missense_Mutation_p.R2195Q	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	2195	Nonhelical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CAGCCCCCACGACCATTCCGA	0.403000													11	24					0	0	1	0	0
LEMD1	93273	broad.mit.edu	37	1	205388426	205388426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205388426G>A	ENST00000367153.4	-	3	239	c.137C>T	c.(136-138)cCc>cTc	p.P46L	LEMD1_ENST00000367154.1_Missense_Mutation_p.P46L|LEMD1_ENST00000367152.1_Intron|LEMD1_ENST00000367149.3_Intron|LEMD1_ENST00000391936.2_Missense_Mutation_p.P46L|LEMD1_ENST00000367151.2_Intron|LEMD1_ENST00000476884.1_Intron	NM_001199050.1	NP_001185979.1	Q68G75	LEMD1_HUMAN	LEM domain containing 1	46						integral to membrane|nuclear envelope				breast(1)|lung(2)	3	Breast(84;0.247)		BRCA - Breast invasive adenocarcinoma(75;0.0938)			TGGTGCACAGGGAGGTGAGAC	0.448000													49	117					0	0	1	0	0
NTSR2	23620	broad.mit.edu	37	2	11809800	11809800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11809800G>A	ENST00000306928.5	-	1	490	c.456C>T	c.(454-456)acC>acT	p.T152T		NM_012344.3	NP_036476.1	O95665	NTR2_HUMAN	neurotensin receptor 2	152					sensory perception	integral to plasma membrane				breast(1)|large_intestine(7)|lung(7)|prostate(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	CCAGCCACCGGGTCCGGCGTG	0.741000													4	6					0	0	1	0	0
PBLD	64081	broad.mit.edu	37	10	70051922	70051922	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70051922G>A	ENST00000358769.2	-	5	559	c.357C>T	c.(355-357)atC>atT	p.I119I	PBLD_ENST00000277795.4_Silent_p.I86I|PBLD_ENST00000309049.4_Silent_p.I119I|PBLD_ENST00000336578.1_Silent_p.I86I|PBLD_ENST00000495025.1_5'UTR|PBLD_ENST00000432941.1_Silent_p.I119I	NM_022129.3	NP_071412.2	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing	119					biosynthetic process		isomerase activity	p.I119I(2)		endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						AGTCCAGGACGATGCCATCCT	0.468000													21	44					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106675690	106675690	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106675690G>A	ENST00000369701.3	+	3	1022	c.795_splice	c.e3+1	p.K265_splice		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	265						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACAAAAGGAAGGTAAGAGACT	0.453000													20	63					0	0	1	0	0
IL33	90865	broad.mit.edu	37	9	6254512	6254512	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:6254512G>A	ENST00000381434.3	+	6	584	c.571G>A	c.(571-573)Gac>Aac	p.D191N	IL33_ENST00000456383.2_Missense_Mutation_p.D149N|IL33_ENST00000417746.2_Missense_Mutation_p.D65N	NM_033439.3	NP_254274.1	O95760	IL33_HUMAN	interleukin 33	191					positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity			breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|stomach(1)|urinary_tract(1)	16		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)		TCCTACAAAAGACTTCTGGTT	0.328000													6	41					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873421	91873421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:91873421C>T	ENST00000373094.1	+	7	4371	c.3526C>T	c.(3526-3528)Cca>Tca	p.P1176S	PCDH11X_ENST00000361655.2_Missense_Mutation_p.P1158S|PCDH11X_ENST00000406881.1_Missense_Mutation_p.P1168S|PCDH11X_ENST00000373097.1_Missense_Mutation_p.P1166S|PCDH11X_ENST00000298274.8_Missense_Mutation_p.P1139S|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000373088.1_Missense_Mutation_p.P1139S	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1176					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCACAGCCCACCACTGTCACA	0.567000													40	25					0	0	1	0	0
STC1	6781	broad.mit.edu	37	8	23702404	23702404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:23702404C>T	ENST00000290271.2	-	4	906	c.623G>A	c.(622-624)cGa>cAa	p.R208Q	STC1_ENST00000524323.1_Missense_Mutation_p.R139Q	NM_003155.2	NP_003146.1	P52823	STC1_HUMAN	stanniocalcin 1	208					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GAAGTCAGCTCGTGGGTGTGT	0.557000													17	77					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171173052	171173052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171173052G>A	ENST00000441535.1	+	6	793	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K	RP1-127D3.4_ENST00000422841.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000209929.7_Missense_Mutation_p.E226K|RP1-127D3.4_ENST00000445290.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	226					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCGTATCTCTGAAGATGGCTA	0.468000													17	57					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74883533	74883533	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74883533C>T	ENST00000289575.5	+	7	1286	c.891C>T	c.(889-891)ttC>ttT	p.F297F	SLCO2B1_ENST00000532236.1_Silent_p.F181F|SLCO2B1_ENST00000525650.1_Silent_p.F153F|SLCO2B1_ENST00000526660.1_3'UTR|SLCO2B1_ENST00000341411.4_Silent_p.F70F|SLCO2B1_ENST00000454962.2_Silent_p.F70F|SLCO2B1_ENST00000531756.1_Silent_p.F42F|SLCO2B1_ENST00000428359.2_Silent_p.F275F	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	297					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	ACTTCTTCTTCCCCAAGGAAA	0.577000													39	78					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58302916	58302916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:58302916C>T	ENST00000249750.4	-	4	1191	c.424G>A	c.(424-426)Ggc>Agc	p.G142S	ALDH1A2_ENST00000537372.1_Missense_Mutation_p.G121S|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.G113S|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.G46S|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.G142S	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	142					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTGATGACGCCCTGCAAATCC	0.433000													23	52					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6943310	6943310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6943310G>A	ENST00000389658.3	-	62	9029	c.8936C>T	c.(8935-8937)aCt>aTt	p.T2979I		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2979	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCTTGAAGAGTGTGCCATTT	0.493000													37	126					0	0	1	0	0
SCIN	85477	broad.mit.edu	37	7	12683868	12683868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:12683868G>A	ENST00000297029.5	+	12	1788	c.1687G>A	c.(1687-1689)Gag>Aag	p.E563K	SCIN_ENST00000445618.2_Missense_Mutation_p.E316K|SCIN_ENST00000519209.1_Missense_Mutation_p.E316K	NM_001112706.2	NP_001106177.1	Q9Y6U3	ADSV_HUMAN	scinderin	563	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	17				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CCAGGAGGAGGAGAAAGGAGC	0.473000													5	13					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158974450	158974450	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158974450G>A	ENST00000605860.1	+	7	671	c.625_splice	c.e7+1	p.G209_splice	UPP2_ENST00000460456.1_Intron|UPP2_ENST00000005756.4_Splice_Site_p.G152_splice|UPP2_ENST00000409859.4_Splice_Site_p.G209_splice			O95045	UPP2_HUMAN	uridine phosphorylase 2	152					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						AGGGGGAATAGGTGAGACGGA	0.433000													29	95					0	0	1	0	0
DNAJC21	134218	broad.mit.edu	37	5	34945064	34945064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:34945064C>T	ENST00000382021.2	+	8	1303	c.1076C>T	c.(1075-1077)cCt>cTt	p.P359L	DNAJC21_ENST00000342382.4_Missense_Mutation_p.P359L|DNAJC21_ENST00000303525.7_Missense_Mutation_p.P359L	NM_194283.3	NP_919259.3	Q5F1R6	DJC21_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 21	359	Glu-rich.				protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			TTTTCAAGACCTCAAATTGAT	0.358000													41	115					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35831879	35831879	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35831879C>T	ENST00000085219.5	+	7	1411	c.1345C>T	c.(1345-1347)Ccc>Tcc	p.P449S	CD22_ENST00000536635.2_Missense_Mutation_p.P361S|CD22_ENST00000270311.6_Missense_Mutation_p.P329S|CD22_ENST00000544992.2_Missense_Mutation_p.P449S|CD22_ENST00000594250.1_Missense_Mutation_p.P272S|CD22_ENST00000419549.2_Missense_Mutation_p.P277S|CD22_ENST00000341773.6_Missense_Mutation_p.P272S	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	449	Ig-like C2-type 4.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TTCCAGTAACCCCAGTGTTAC	0.522000													19	53					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98547864	98547864	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:98547864C>T	ENST00000359863.4	+	37	5501	c.5292C>T	c.(5290-5292)ttC>ttT	p.F1764F	TRRAP_ENST00000355540.3_Silent_p.F1746F|TRRAP_ENST00000446306.3_Silent_p.F1745F	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1764					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ACCCCAACTTCGGAGATGAAT	0.418000													42	85					0	0	1	0	0
PTGIR	5739	broad.mit.edu	37	19	47127184	47127184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47127184G>A	ENST00000291294.2	-	2	432	c.299C>T	c.(298-300)aCc>aTc	p.T100I	PTGIR_ENST00000597185.1_Intron|PTGIR_ENST00000596260.1_Missense_Mutation_p.T100I|PTGIR_ENST00000598865.1_Intron|PTGIR_ENST00000594275.1_Intron	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	100					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GCCGAAGAAGGTCATGGCGAA	0.701000													4	11					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50480161	50480161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50480161G>A	ENST00000266182.6	-	7	718	c.719C>T	c.(718-720)gCc>gTc	p.A240V	TTLL8_ENST00000440475.1_Missense_Mutation_p.A240V					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CCCCAGGTAGGCCTGGCACAC	0.612000													7	15					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16126970	16126970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16126970C>T	ENST00000399408.2	+	6	795	c.620C>T	c.(619-621)cCc>cTc	p.P207L	ABCC1_ENST00000349029.5_Missense_Mutation_p.P207L|ABCC1_ENST00000345148.5_Missense_Mutation_p.P207L|ABCC1_ENST00000346370.5_Missense_Mutation_p.P207L|ABCC1_ENST00000399410.3_Missense_Mutation_p.P207L|ABCC1_ENST00000351154.5_Missense_Mutation_p.P207L			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	207					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CACTAGAATCCCTGCCCAGAG	0.547000													15	67					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53544456	53544456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53544456C>T	ENST00000371500.3	+	10	1702	c.1361C>T	c.(1360-1362)gCc>gTc	p.A454V	PODN_ENST00000312553.5_Missense_Mutation_p.A473V|PODN_ENST00000395871.2_Missense_Mutation_p.A331V|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	425					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CACCGCGACGCCTTCCGCAAG	0.637000													38	81					0	0	1	0	0
TCEAL2	140597	broad.mit.edu	37	X	101381827	101381827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:101381827G>A	ENST00000372780.1	+	3	244	c.25G>A	c.(25-27)Gaa>Aaa	p.E9K	TCEAL2_ENST00000329035.2_Missense_Mutation_p.E9K|TCEAL2_ENST00000476749.1_3'UTR	NM_080390.3	NP_525129.1	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						CAATGAAAATGAAGGAATGCC	0.463000													25	18					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55839150	55839150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:55839150G>A	ENST00000302000.6	-	3	425	c.331C>T	c.(331-333)Ccc>Tcc	p.P111S	PYGO1_ENST00000563719.1_Missense_Mutation_p.P111S	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	111	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		ATTCTTGGGGGAACGTGAGGT	0.473000													14	133					0	0	1	0	0
ESYT2	57488	broad.mit.edu	37	7	158536344	158536344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:158536344G>A	ENST00000251527.5	-	16	1816	c.1751C>T	c.(1750-1752)tCc>tTc	p.S584F	ESYT2_ENST00000435514.2_Missense_Mutation_p.S19F	NM_020728.2	NP_065779.1	A0FGR8	ESYT2_HUMAN	extended synaptotagmin-like protein 2	612	C2 2.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(16)|prostate(2)	32						GTTCCCCAGGGAACACTGGTG	0.557000													13	38					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37271804	37271804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:37271804C>T	ENST00000373091.3	-	14	2231	c.2215G>A	c.(2215-2217)Gag>Aag	p.E739K	GRIK3_ENST00000373093.4_Missense_Mutation_p.E739K	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	739					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GTGGTGGACTCCATGAGCAGC	0.622000													23	88					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51729288	51729288	+	Silent	SNP	C	C	T	rs141510568	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51729288C>T	ENST00000436584.2	+	2	322	c.267C>T	c.(265-267)ttC>ttT	p.F89F	CD33_ENST00000262262.4_Silent_p.F216F|CD33_ENST00000391796.3_Silent_p.F216F|CD33_ENST00000421133.2_Silent_p.F89F			P20138	CD33_HUMAN	CD33 molecule	216	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AGGTGAAGTTCGCTGGAGCTG	0.627000													16	37					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12978676	12978676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12978676C>T	ENST00000251472.4	+	20	2490	c.2451C>T	c.(2449-2451)gcC>gcT	p.A817A		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	817					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						AGGATGAGGCCCGGCTGCGCA	0.731000													3	18					0	0	1	0	0
SPPL2B	56928	broad.mit.edu	37	19	2352957	2352957	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2352957C>T	ENST00000452401.2	+	0	1669				AC005258.3_ENST00000590001.1_RNA			Q8TCT7	PSL1_HUMAN	signal peptide peptidase like 2B							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCTACCTCCATCTCCGTGG	0.682000													12	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593736	179593736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179593736C>T	ENST00000589042.1	-	65	19253	c.19029G>A	c.(19027-19029)gtG>gtA	p.V6343V	TTN_ENST00000342992.6_Silent_p.V5099V|TTN_ENST00000591111.1_Silent_p.V6026V|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6026	Ig-like 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACACTGTCCACAAATGAAA	0.423000													5	25					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067485	190067485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190067485G>A	ENST00000367462.3	-	8	2195	c.1964C>T	c.(1963-1965)tCc>tTc	p.S655F	FAM5C_ENST00000534846.1_Missense_Mutation_p.S553F|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		655						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CAGGTTCCGGGAAGGGTCAAT	0.443000													42	131					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93637034	93637034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:93637034G>A	ENST00000375754.4	+	9	1232	c.1084G>A	c.(1084-1086)Gag>Aag	p.E362K	SYK_ENST00000375746.1_Missense_Mutation_p.E362K|SYK_ENST00000375751.4_Missense_Mutation_p.E339K|SYK_ENST00000375747.1_Missense_Mutation_p.E339K	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	362	Linker.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						CAGGCCCAAGGAGGTTTACCT	0.527000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								45	210					0	0	1	0	0
WDR7	23335	broad.mit.edu	37	18	54363639	54363639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:54363639C>T	ENST00000254442.3	+	12	1735	c.1524C>T	c.(1522-1524)ttC>ttT	p.F508F	WDR7_ENST00000589935.1_Intron|WDR7_ENST00000357574.3_Silent_p.F508F	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	508										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		AACATATCTTCTGTGTTCATG	0.363000													33	103					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57528795	57528795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57528795G>A	ENST00000420713.1	+	4	740	c.628G>A	c.(628-630)Gag>Aag	p.E210K		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TCATACTAGGGAGAAGTCTTA	0.358000													5	25					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802863	185802863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:185802863C>T	ENST00000302277.6	+	4	3334	c.2740C>T	c.(2740-2742)Ccc>Tcc	p.P914S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	914						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTCCAATGATCCCACCACATC	0.398000													22	75					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097768	167097768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167097768G>A	ENST00000361200.2	+	6	3566	c.3400G>A	c.(3400-3402)Gat>Aat	p.D1134N	DUSP27_ENST00000443333.1_Missense_Mutation_p.D1134N|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.D1134N			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1134					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGAAATGGACGATGAAGCCAT	0.522000													16	40					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92826581	92826581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92826581C>T	ENST00000394468.2	-	7	1251	c.1174G>A	c.(1174-1176)Gaa>Aaa	p.E392K	HEPACAM2_ENST00000341723.4_Missense_Mutation_p.E380K|HEPACAM2_ENST00000453812.2_Missense_Mutation_p.E415K|HEPACAM2_ENST00000492616.1_5'UTR|HEPACAM2_ENST00000440868.1_Silent_p.Q371Q	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	392						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						TTCCTGTATTCTGTTTCTGGC	0.303000													22	52					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575346	136575346	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136575346C>T	ENST00000264162.2	-	6	1282	c.1272G>A	c.(1270-1272)gcG>gcA	p.A424A		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	424	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCTCCAGCGTCGCTTGGCCCT	0.632000													30	93					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150656705	150656705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150656705G>A	ENST00000392968.2	-	1	1259	c.139C>T	c.(139-141)Cat>Tat	p.H47Y	KCNH2_ENST00000430723.3_Missense_Mutation_p.H143Y|KCNH2_ENST00000262186.5_Missense_Mutation_p.H143Y			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	143	PAS.		G -> V (in LQT2).		blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TTGGTGTCATGAGCCGGGGAC	0.592000													25	65					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79440571	79440571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79440571C>T	ENST00000264895.6	+	67	10916	c.10476C>T	c.(10474-10476)gcC>gcT	p.A3492A		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3487					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GGGGCTGGGCCTCCTTGGAGC	0.527000													68	172					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97620289	97620289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97620289G>A	ENST00000371203.5	+	7	1311	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	ENTPD1_ENST00000543964.1_Missense_Mutation_p.E272K|RP11-429G19.3_ENST00000433113.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000539125.1_Missense_Mutation_p.E242K|ENTPD1_ENST00000371205.4_Missense_Mutation_p.E380K|ENTPD1_ENST00000371207.3_Missense_Mutation_p.E392K|ENTPD1_ENST00000453258.2_Missense_Mutation_p.E387K	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	380					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		AGTCTCTCAGGAAAAGGTGAC	0.433000													14	34					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107330682	107330682	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107330682G>A	ENST00000265715.3	+	10	1487	c.1263_splice	c.e10+1	p.Q421_splice		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	421			Q -> R (in Pendred syndrome/deafness individuals).		regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GAAAGACACAGGTAGGAACAA	0.507000									Pendred syndrome				33	71					0	0	1	0	0
LHX1	3975	broad.mit.edu	37	17	35297980	35297980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:35297980G>A	ENST00000254457.5	+	3	1882	c.471G>A	c.(469-471)gaG>gaA	p.E157E	RP11-445F12.2_ENST00000607336.1_RNA	NM_005568.3	NP_005559.2	P48742	LHX1_HUMAN	LIM homeobox 1	157					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Breast(25;0.00607)				AGGACTCGGAGAGCGCCAACG	0.632000													19	34					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85974125	85974125	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85974125G>A	ENST00000372117.3	+	17	2431	c.2328G>A	c.(2326-2328)gaG>gaA	p.E776E	CDHR1_ENST00000332904.3_Intron|CDHR1_ENST00000440770.2_Silent_p.E480E	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	776	Pro-rich.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						CTCCCAATGAGAACTGTAACA	0.612000													46	103					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70904966	70904966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70904966G>A	ENST00000264436.3	-	12	1871	c.1427C>T	c.(1426-1428)cCg>cTg	p.P476L	ADD2_ENST00000413157.2_Missense_Mutation_p.P476L|ADD2_ENST00000407644.2_Missense_Mutation_p.P476L|ADD2_ENST00000355733.3_Missense_Mutation_p.P476L|ADD2_ENST00000430656.1_Missense_Mutation_p.P492L	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	476					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						GATGCGAATCGGCATGCCACT	0.532000													8	81					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232551301	232551301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:232551301G>A	ENST00000366630.1	-	18	5059	c.4701C>T	c.(4699-4701)ctC>ctT	p.L1567L	SIPA1L2_ENST00000262861.4_Silent_p.L1567L|SIPA1L2_ENST00000308942.4_Silent_p.L641L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1567					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CTGTGTCCGGGAGGGGCATCA	0.542000													39	123					0	0	1	0	0
ZNF200	7752	broad.mit.edu	37	16	3274282	3274282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3274282G>A	ENST00000431561.3	-	5	1410	c.798C>T	c.(796-798)taC>taT	p.Y266Y	ZNF200_ENST00000396870.4_Silent_p.Y265Y|ZNF200_ENST00000575948.1_Silent_p.Y265Y|AJ003147.9_ENST00000576468.1_RNA|ZNF200_ENST00000396868.3_Silent_p.Y265Y|ZNF200_ENST00000414144.2_Silent_p.Y266Y|ZNF200_ENST00000396871.4_Silent_p.Y265Y	NM_001145447.1|NM_003454.3	NP_001138919.1|NP_003445.2	P98182	ZN200_HUMAN	zinc finger protein 200	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	17						GGGAAATGAGGTAAGAACTTT	0.408000													30	49					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53157753	53157753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53157753G>A	ENST00000296292.3	-	3	314	c.253C>T	c.(253-255)Ctg>Ttg	p.L85L	RFT1_ENST00000394738.3_Intron	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	85					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		AGCCACAGCAGGTTGAGGGTC	0.552000													25	49					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62547779	62547779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:62547779G>A	ENST00000430451.2	+	4	1418	c.1221G>A	c.(1219-1221)caG>caA	p.Q407Q	SYT16_ENST00000446982.2_3'UTR|RP11-355I22.5_ENST00000553990.1_lincRNA	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	407	C2 1.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		CGAACATACAGAGAGGGCCCA	0.592000													8	26					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14306775	14306775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:14306775C>T	ENST00000378053.3	-	2	1634	c.1378G>A	c.(1378-1380)Gaa>Aaa	p.E460K	FLRT3_ENST00000341420.4_Missense_Mutation_p.E460K|MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	460	Fibronectin type-III.		E -> D (in dbSNP:rs35253731).		cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TCACTGCGTTCCCCTGTTACA	0.463000													33	84					0	0	1	0	0
SDF2L1	23753	broad.mit.edu	37	22	21998344	21998344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21998344C>T	ENST00000248958.4	+	3	622	c.546C>T	c.(544-546)atC>atT	p.I182I		NM_022044.2	NP_071327.2	Q9HCN8	SDF2L_HUMAN	stromal cell-derived factor 2-like 1	182	MIR 3.					endoplasmic reticulum lumen|membrane				prostate(1)	1	Colorectal(54;0.105)					GAAGCCCCATCCGTGGGCAGC	0.602000											OREG0026342	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	31					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43251400	43251400	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43251400G>A	ENST00000259750.4	+	14	3005	c.2922G>A	c.(2920-2922)ggG>ggA	p.G974G		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	974						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TGGAGGAGGGGGCCCGAGCGC	0.687000													33	44					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64640081	64640081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:64640081C>T	ENST00000498707.1	-	8	1606	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.E394K|ADAMTS9_ENST00000459780.1_Missense_Mutation_p.E422K	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	422	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CCACTATCTTCACTAATAGAA	0.398000													26	178					0	0	1	0	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959603	45959603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45959603G>A	ENST00000400375.1	-	1	475	c.431C>T	c.(430-432)cCt>cTt	p.P144L	TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	144	24 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						GCAGCAAACAGGCACACAGCA	0.582000													40	144					0	0	1	0	0
HPCA	3208	broad.mit.edu	37	1	33359166	33359166	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33359166G>A	ENST00000373467.3	+	3	522	c.420G>A	c.(418-420)gaG>gaA	p.E140E	HPCA_ENST00000480118.1_3'UTR	NM_002143.2	NP_002134.2	P84074	HPCA_HUMAN	hippocalcin	140							actin binding|calcium ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				AGATGCCGGAGGACGAGTCGA	0.647000													9	50					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45860744	45860744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45860744C>T	ENST00000397928.1	+	31	4787	c.4342C>T	c.(4342-4344)Cac>Tac	p.H1448Y	TRPM2_ENST00000300481.9_Missense_Mutation_p.H1394Y|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Missense_Mutation_p.H1448Y|TRPM2_ENST00000397932.2_Missense_Mutation_p.H1498Y	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1448	Nudix hydrolase.					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CGTCAGCGTCCACTTCCAGGA	0.622000													46	95					0	0	1	0	0
FBXO28	23219	broad.mit.edu	37	1	224345107	224345107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:224345107C>T	ENST00000366862.5	+	5	809	c.766C>T	c.(766-768)Cct>Tct	p.P256S	FBXO28_ENST00000424254.2_3'UTR	NM_015176.3	NP_055991.1	Q9NVF7	FBX28_HUMAN	F-box protein 28	256										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(2)|skin(1)	10	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		CAAGCAAAATCCTTCAAGACA	0.458000													26	140					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46288297	46288297	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:46288297G>A	ENST00000378966.3	+	2	1445	c.1029G>A	c.(1027-1029)gaG>gaA	p.E343E	SPERT_ENST00000310521.1_Silent_p.E379E			Q8NA61	SPERT_HUMAN	spermatid associated	379						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		TGCAGGAGGAGAACAGGACCC	0.657000													4	15					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155485641	155485641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155485641G>A	ENST00000461783.3	+	10	3394	c.2121G>A	c.(2119-2121)ccG>ccA	p.P707P	TIAM2_ENST00000318981.5_Silent_p.P707P|TIAM2_ENST00000367174.2_Silent_p.P59P|TIAM2_ENST00000528391.2_Silent_p.P19P|TIAM2_ENST00000456877.2_Silent_p.P19P|TIAM2_ENST00000529824.2_Silent_p.P707P|TIAM2_ENST00000360366.4_Silent_p.P707P|TIAM2_ENST00000456144.1_Silent_p.P707P			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	707					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GGGAGTTACCGAACCCAAAGA	0.542000													62	88					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13922221	13922221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13922221C>T	ENST00000265104.4	-	5	759	c.655G>A	c.(655-657)Gag>Aag	p.E219K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	219	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTCACCTTCTCCTTCAGACTC	0.488000									Kartagener syndrome				11	25					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64668681	64668681	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:64668681G>A	ENST00000543942.2	-	11	2210	c.1584_splice	c.e11+1	p.I528_splice	RPS11P6_ENST00000535684.1_RNA|C12orf56_ENST00000536975.1_5'UTR|C12orf56_ENST00000333722.5_Splice_Site_p.I368_splice	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	531										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		AGATACTTACGATGGGAGGAC	0.373000													24	61					0	0	1	0	0
LAPTM5	7805	broad.mit.edu	37	1	31206707	31206707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:31206707C>T	ENST00000294507.3	-	8	831	c.757G>A	c.(757-759)Ggc>Agc	p.G253S		NM_006762.2	NP_006753.1	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	253	Pro-rich.				transport	integral to plasma membrane|lysosomal membrane				large_intestine(2)|lung(7)|skin(1)	10		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGCTGGGCCCCCCTCTGGG	0.602000													10	29					0	0	1	0	0
LSAMP	4045	broad.mit.edu	37	3	115805287	115805287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:115805287G>A	ENST00000490035.1	-	2	771	c.272C>T	c.(271-273)tCt>tTt	p.S91F	LSAMP_ENST00000539563.1_Missense_Mutation_p.S88F	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	91	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GTATTCCAGAGAATGGCGTTT	0.507000													17	72					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12979903	12979903	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12979903C>T	ENST00000251472.4	+	22	2836	c.2797C>T	c.(2797-2799)Ctt>Ttt	p.L933F		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	933					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						AAGTTCACCCCTTGCTAGTCC	0.562000													23	72					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103191703	103191703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103191703G>A	ENST00000424685.2	-	41	6272	c.6113C>T	c.(6112-6114)cCa>cTa	p.P2038L	RELN_ENST00000343529.5_Missense_Mutation_p.P2038L|RELN_ENST00000428762.1_Missense_Mutation_p.P2038L			P78509	RELN_HUMAN	reelin	2038					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGTCTCACTGGATCCGCGGA	0.502000													18	48					0	0	1	0	0
KLK9	284366	broad.mit.edu	37	19	51507037	51507037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51507037G>A	ENST00000250366.6	-	4	559	c.526C>T	c.(526-528)Cac>Tac	p.H176Y	KLK9_ENST00000376832.4_Missense_Mutation_p.H176Y|CTB-147C22.9_ENST00000594512.1_RNA|KLK9_ENST00000594211.1_Missense_Mutation_p.H176Y	NM_012315.1	NP_036447.1	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9	176	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		TATGCCCAGTGACAGAGTTTG	0.567000													28	44					0	0	1	0	0
LYZL1	84569	broad.mit.edu	37	10	29580895	29580895	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:29580895G>A	ENST00000375500.3	+	2	294	c.237G>A	c.(235-237)agG>agA	p.R79R		NM_032517.4	NP_115906.3	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	33					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)|cervix(2)|large_intestine(2)|lung(5)|skin(1)	11		Breast(68;0.203)				TATTCTCGAGGGCTGGCCTGG	0.522000													26	23					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57415241	57415241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57415241C>T	ENST00000543257.1	-	7	1261	c.695G>A	c.(694-696)cGa>cAa	p.R232Q	C8B_ENST00000371237.4_Missense_Mutation_p.R284Q|C8B_ENST00000535057.1_Missense_Mutation_p.R222Q	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	284	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ATGAGAGAATCGTTTGGTTCT	0.353000													29	40					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56098199	56098199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:56098199G>A	ENST00000394555.2	-	9	1495	c.1060C>T	c.(1060-1062)Cat>Tat	p.H354Y	EFEMP1_ENST00000394554.1_Missense_Mutation_p.H354Y|EFEMP1_ENST00000355426.3_Missense_Mutation_p.H354Y|EFEMP1_ENST00000424836.2_Missense_Mutation_p.H216Y	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	354	EGF-like 6; calcium-binding (Potential).|Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AAGCCGCCATGATAATTCCAA	0.378000													21	65					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147027949	147027949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147027949C>T	ENST00000265272.5	-	5	1393	c.926G>A	c.(925-927)cGa>cAa	p.R309Q	JAKMIP2_ENST00000507386.1_Missense_Mutation_p.R309Q|JAKMIP2_ENST00000333010.6_Missense_Mutation_p.R267Q	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	309						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTTCATTTCGTTCATCTCC	0.303000													36	98					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81706230	81706230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81706230C>T	ENST00000372292.3	-	2	226	c.186G>A	c.(184-186)gaG>gaA	p.E62E		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	62	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			GGTCCCCCTTCTCGCCCCGAG	0.602000													24	47					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3703511	3703511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3703511G>A	ENST00000378251.1	-	2	1006	c.979C>T	c.(979-981)Ccc>Tcc	p.P327S		NM_020710.2	NP_065761.1	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	327					translation		phenylalanine-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		CGGACCTCGGGGCTCACTCTG	0.647000													4	12					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155643132	155643132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155643132C>T	ENST00000496455.1	+	12	1872	c.1537C>T	c.(1537-1539)Cca>Tca	p.P513S	GMPS_ENST00000295920.7_Missense_Mutation_p.P414S	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	513					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTTCTTGCTGCCAATTAAAAC	0.403000			T	MLL	AML								20	21					0	0	1	0	0
CECR5	27440	broad.mit.edu	37	22	17630511	17630511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17630511G>A	ENST00000336737.4	-	2	276	c.251C>T	c.(250-252)cCc>cTc	p.P84L	CECR5_ENST00000155674.5_Missense_Mutation_p.P54L|CECR5_ENST00000399852.3_Intron|CECR5_ENST00000480451.1_5'UTR	NM_033070.2	NP_149061.1	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	84							hydrolase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(10)|pancreas(1)|prostate(1)	21		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				AAAAACCACGGGCACCCGCAG	0.587000													63	121					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64408417	64408417	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:64408417T>C	ENST00000262043.3	+	8	3244	c.2904T>C	c.(2902-2904)tcT>tcC	p.S968S	PHF3_ENST00000393387.1_Silent_p.S968S			Q92576	PHF3_HUMAN	PHD finger protein 3	968	TFIIS central.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding	p.R971fs*6(1)		breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGCTTTTCTCTTTTTTTCGGG	0.303000													34	61					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61777953	61777953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:61777953C>T	ENST00000423902.2	+	38	8934	c.8455C>T	c.(8455-8457)Cct>Tct	p.P2819S	CHD7_ENST00000524602.1_Missense_Mutation_p.P770S	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2819					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GTTGAATAACCCTCTGTCAGC	0.547000													4	18					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	828709	828709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:828709G>A	ENST00000293892.3	-	4	1012	c.1013C>T	c.(1012-1014)cCc>cTc	p.P338L	MSLNL_ENST00000442466.1_Missense_Mutation_p.P71L			Q96KJ4	MSLNL_HUMAN	mesothelin-like	71					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CTGGTCCCGGGGCAGCTGGCT	0.692000													3	5					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679638	100679638	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100679638G>A	ENST00000306151.4	+	3	5005	c.4941G>A	c.(4939-4941)gaG>gaA	p.E1647E		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1647	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAGTCCTGAGGCTAGCACCC	0.502000													130	516					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148963691	148963691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148963691C>T	ENST00000434415.1	+	2	453	c.290C>T	c.(289-291)gCc>gTc	p.A97V		NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	97					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GGCAAGTGGGCCGTGCTGGGG	0.627000													30	99					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102714185	102714185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102714185C>T	ENST00000299855.5	-	1	349	c.93G>A	c.(91-93)atG>atA	p.M31I		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	31					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	GAACAAGGTTCATGCTGGTGT	0.488000													11	27					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173552675	173552675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173552675C>T	ENST00000367714.3	-	6	1032	c.610G>A	c.(610-612)Ggc>Agc	p.G204S	RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Missense_Mutation_p.G102S	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	204					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										ATTCTGTTGCCCCGAAAATTT	0.279000													28	81					0	0	1	0	0
KCNN1	3780	broad.mit.edu	37	19	18092715	18092715	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18092715C>A	ENST00000601725.1	+	0	331																											TGCTGTCCATCCCCATGTTCC	0.672000													6	21					0.00198382	0.00198538	1	1	0
FAM65B	9750	broad.mit.edu	37	6	24848321	24848321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24848321G>A	ENST00000259698.4	-	12	1184	c.1009C>T	c.(1009-1011)Cag>Tag	p.Q337*	FAM65B_ENST00000538035.1_Nonsense_Mutation_p.Q366*|FAM65B_ENST00000510784.2_Nonsense_Mutation_p.Q371*|FAM65B_ENST00000378023.4_Nonsense_Mutation_p.Q337*|FAM65B_ENST00000540914.1_Nonsense_Mutation_p.Q337*	NM_014722.2	NP_055537.2	Q9Y4F9	FA65B_HUMAN	family with sequence similarity 65, member B	337					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	25						ATTCTCCTCTGAAGGGCTGCT	0.517000													15	23					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51376660	51376660	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:51376660G>A	ENST00000216392.7	-	17	2462	c.2130C>T	c.(2128-2130)ttC>ttT	p.F710F	PYGL_ENST00000544180.2_Silent_p.F676F|PYGL_ENST00000532462.1_Silent_p.F710F	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	710					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TGCCAAAGATGAACAGGTTCT	0.502000													119	288					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4945447	4945447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4945447G>A	ENST00000321961.2	-	1	190	c.123C>T	c.(121-123)atC>atT	p.I41I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGTTCCCCAAGATAACTGTCA	0.502000													18	63					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163241435	163241435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163241435C>T	ENST00000332142.5	-	13	2824	c.2725G>A	c.(2725-2727)Gat>Aat	p.D909N		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	909					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TCTTCAGGATCATTTGTACTG	0.338000													36	70					0	0	1	0	0
AGAP6	414189	broad.mit.edu	37	10	51751483	51751483	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:51751483C>T	ENST00000374056.4	+	2	669	c.271C>T	c.(271-273)Cag>Tag	p.Q91*	AGAP6_ENST00000412531.3_Nonsense_Mutation_p.Q114*			C9IYN2	C9IYN2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 6	114					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(8)|prostate(3)|skin(1)|stomach(2)	29						CACAATATTCCAGAGGAACTC	0.348000													17	176					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85279804	85279804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85279804C>T	ENST00000440886.1	-	2	825	c.787G>A	c.(787-789)Ggc>Agc	p.G263S	LPAR3_ENST00000370611.3_Missense_Mutation_p.G263S|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	263					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						CAGTTCAGGCCGTCGAGGAGC	0.582000													34	65					0	0	1	0	0
GPR21	2844	broad.mit.edu	37	9	125797421	125797421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125797421C>T	ENST00000373642.1	+	1	616	c.576C>T	c.(574-576)acC>acT	p.T192T	RABGAP1_ENST00000373647.4_Intron|RABGAP1_ENST00000373643.5_Intron|RABGAP1_ENST00000493854.1_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	192						integral to plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						CCTACTTCACCCTGTTCATCG	0.493000													27	112					0	0	1	0	0
OXSM	54995	broad.mit.edu	37	3	25832704	25832704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:25832704C>T	ENST00000280701.3	+	2	292	c.193C>T	c.(193-195)Cgt>Tgt	p.R65C	OXSM_ENST00000449808.1_3'UTR|OXSM_ENST00000420173.2_Missense_Mutation_p.R65C	NM_017897.2	NP_060367.1	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial	65					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity	p.R65C(1)		breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						GGTTTGGGATCGTCTTATCGG	0.463000													57	134					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62299256	62299256	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62299256G>A	ENST00000378024.4	-	5	2907	c.2633C>T	c.(2632-2634)cCc>cTc	p.P878L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	878					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTCATCTTGGGCATCTTCAG	0.498000													136	355					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42711363	42711363	+	Missense_Mutation	SNP	G	G	A	rs45590635		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:42711363G>A	ENST00000230882.4	+	7	863	c.673G>A	c.(673-675)Gaa>Aaa	p.E225K	GHR_ENST00000357703.3_Missense_Mutation_p.E203K|GHR_ENST00000537449.1_Missense_Mutation_p.E38K	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	225	Fibronectin type-III.				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AGTGGATAAGGAATATGAAGT	0.398000													26	171					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50472793	50472793	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50472793C>T	ENST00000266182.6	-	9	1019	c.1020G>A	c.(1018-1020)cgG>cgA	p.R340R	TTLL8_ENST00000440475.1_Silent_p.R324R					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CACCTCGGCCCCGGGACTTGG	0.597000													5	41					0	0	1	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23445473	23445473	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23445473C>T	ENST00000526079.1	+	0	2293					NR_027407.1|NR_033350.1																						ACATGACCATCGTCAAAGACC	0.433000													9	162					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7811414	7811414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:7811414G>A	ENST00000420658.1	-	9	1253	c.981C>T	c.(979-981)atC>atT	p.I327I	AFAP1_ENST00000358461.2_Silent_p.I327I|AFAP1_ENST00000360265.4_Silent_p.I327I|AFAP1_ENST00000382543.3_Silent_p.I327I	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	327						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						CCAGACTGATGATCTTGGTGA	0.498000													22	40					0	0	1	0	0
CREG2	200407	broad.mit.edu	37	2	102000095	102000095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102000095G>A	ENST00000324768.4	-	2	648	c.511C>T	c.(511-513)Cct>Tct	p.P171S	CREG2_ENST00000495455.1_5'UTR	NM_153836.3	NP_722578.1	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2	171						extracellular region	FMN binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						TAGAAGAAAGGAATCCCAGTG	0.517000													23	63					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370370	126370370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126370370G>A	ENST00000394329.3	+	9	8212	c.8199G>A	c.(8197-8199)agG>agA	p.R2733R	FAT4_ENST00000335110.5_Silent_p.R1031R	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2733	Cadherin 26.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTTTGGACAGGGAAAAAGTAT	0.348000													8	140					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603011	138603011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138603011G>A	ENST00000440172.1	-	2	1409	c.1361C>T	c.(1360-1362)aCc>aTc	p.T454I	KIAA1549_ENST00000422774.1_Missense_Mutation_p.T454I|KIAA1549_ENST00000242365.4_Missense_Mutation_p.T404I	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	454						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TTCCAGCACGGTCATGCACAG	0.522000			O	BRAF	pilocytic astrocytoma								26	58					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969396	140969396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140969396G>A	ENST00000298296.1	+	4	723	c.723G>A	c.(721-723)ctG>ctA	p.L241L	MAGEC3_ENST00000536088.1_Intron|MAGEC3_ENST00000448920.1_Intron|MAGEC3_ENST00000443323.2_Intron	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	241	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					GCATTTCCCTGACAGAAGTGG	0.483000													78	65					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86124487	86124487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:86124487C>T	ENST00000394518.2	+	7	3283	c.3188C>T	c.(3187-3189)tCt>tTt	p.S1063F	AKAP13_ENST00000361243.2_Missense_Mutation_p.S1063F	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1063					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						AGTCAGCCTTCTCCTCTGGAT	0.532000													18	113					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89392839	89392839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89392839C>T	ENST00000439576.2	+	10	2277	c.1903C>T	c.(1903-1905)Ccc>Tcc	p.P635S	ACAN_ENST00000558207.1_Missense_Mutation_p.P635S|ACAN_ENST00000352105.7_Missense_Mutation_p.P635S|ACAN_ENST00000559004.1_Missense_Mutation_p.P635S|ACAN_ENST00000561243.1_Missense_Mutation_p.P635S	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	635					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCTCCGCTACCCCATCGTCAC	0.687000													6	21					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69682301	69682301	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69682301C>T	ENST00000265403.7	+	1	591	c.564C>T	c.(562-564)ttC>ttT	p.F188F	UGT2B10_ENST00000458688.2_Intron	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	188					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						GATTTATTTTCCCTCCTTCCT	0.398000													35	120					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51122405	51122405	+	Silent	SNP	C	C	T	rs61745502	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51122405C>T	ENST00000301180.5	+	30	3619	c.3585C>T	c.(3583-3585)atC>atT	p.I1195I		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	1195						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						CTCGGCAGATCGCCATCTGCC	0.527000													7	61					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32239700	32239700	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32239700C>T	ENST00000400246.1	+	29	2845	c.2703C>T	c.(2701-2703)ttC>ttT	p.F901F	DEPDC5_ENST00000382111.2_Silent_p.F901F|DEPDC5_ENST00000400248.1_Silent_p.F892F|DEPDC5_ENST00000400249.2_Silent_p.F892F|DEPDC5_ENST00000382105.2_Silent_p.F823F|DEPDC5_ENST00000535622.1_Silent_p.F823F|DEPDC5_ENST00000266091.3_Silent_p.F901F|DEPDC5_ENST00000382112.3_Silent_p.F892F			O75140	DEPD5_HUMAN	DEP domain containing 5	892					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ACTCAGAGTTCGTCTCCTGCT	0.493000													46	100					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72326435	72326435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72326435G>A	ENST00000263563.6	+	20	2785	c.2517G>A	c.(2515-2517)cgG>cgA	p.R839R		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		TGCGCTACCGGTGGCAGGAGC	0.677000													3	19					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857927	9857927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9857927G>A	ENST00000396573.2	-	14	3783	c.3474C>T	c.(3472-3474)ttC>ttT	p.F1158F	GRIN2A_ENST00000535259.1_Silent_p.F1001F|GRIN2A_ENST00000404927.2_Silent_p.F1158F|GRIN2A_ENST00000562109.1_Silent_p.F1158F|GRIN2A_ENST00000330684.3_Silent_p.F1158F|GRIN2A_ENST00000396575.2_Silent_p.F1158F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1158					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCCCTTGCGGAAGTTTTCAC	0.527000													13	155					0	0	1	0	0
OR52M1	119772	broad.mit.edu	37	11	4566681	4566681	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4566681C>T	ENST00000360213.1	+	1	261	c.261C>T	c.(259-261)ttC>ttT	p.F87F		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGGAATCTTCTGGTTCGGTG	0.512000													23	78					0	0	1	0	0
C11orf52	91894	broad.mit.edu	37	11	111796863	111796863	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111796863G>A	ENST00000278601.5	+	4	408	c.312G>A	c.(310-312)gcG>gcA	p.A104A	C11orf52_ENST00000527286.1_3'UTR|HSPB2-C11orf52_ENST00000534100.1_3'UTR	NM_080659.2	NP_542390.2	Q96A22	CK052_HUMAN	chromosome 11 open reading frame 52	104										lung(2)|ovary(1)	3		all_cancers(61;8.8e-15)|all_epithelial(67;6.27e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.63e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.7e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0512)		CAGAGTATGCGACCCTTCGCT	0.547000													12	48					0	0	1	0	0
C9orf117	286207	broad.mit.edu	37	9	130473762	130473762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130473762G>A	ENST00000373295.2	+	4	882	c.842G>A	c.(841-843)aGa>aAa	p.R281K		NM_001012502.2	NP_001012520.2	Q5JU67	CI117_HUMAN	chromosome 9 open reading frame 117	281										breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	6						AGGCACAAAAGAGGCCACCAG	0.607000													13	62					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32705812	32705812	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32705812C>T	ENST00000380250.3	+	8	1216	c.720C>T	c.(718-720)ttC>ttT	p.F240F		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TTCTTAGATTCCCTGCTGTAA	0.418000													10	47					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22390168	22390168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:22390168G>A	ENST00000334304.5	-	19	3395	c.3126C>T	c.(3124-3126)ttC>ttT	p.F1042F	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	1042					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				GGTGGACCACGAAGAACGCAC	0.473000													50	32					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40572226	40572226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:40572226G>A	ENST00000342449.3	-	39	4750	c.4672C>T	c.(4672-4674)Cgt>Tgt	p.R1558C	BRWD1_ENST00000380800.3_Missense_Mutation_p.R1558C|BRWD1_ENST00000333229.2_Missense_Mutation_p.R1558C	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GAGGATTCACGAGCTCTGGAA	0.443000													23	88					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40076552	40076552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:40076552G>A	ENST00000324616.5	+	8	980	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K	C12orf40_ENST00000398716.1_Missense_Mutation_p.E199K|C12orf40_ENST00000405531.3_Missense_Mutation_p.E276K	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	276										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						AAATGGAAAGGAAGTTTCAAA	0.328000													37	120					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72233974	72233974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:72233974G>A	ENST00000340726.3	-	6	1052	c.413C>T	c.(412-414)tCa>tTa	p.S138L	EYA1_ENST00000388742.4_Missense_Mutation_p.S138L|EYA1_ENST00000388741.2_Missense_Mutation_p.S104L|EYA1_ENST00000303824.7_Missense_Mutation_p.S137L|EYA1_ENST00000419131.1_Missense_Mutation_p.S138L|EYA1_ENST00000388743.2_Missense_Mutation_p.S137L|EYA1_ENST00000388740.3_Missense_Mutation_p.S105L	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	138					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTCACCATATGAGGAAATGCC	0.483000													12	35					0	0	1	0	0
NFKBID	84807	broad.mit.edu	37	19	36387009	36387009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36387009G>A	ENST00000396901.1	-	9	1052	c.479C>T	c.(478-480)gCc>gTc	p.A160V	NFKBID_ENST00000606253.1_Missense_Mutation_p.A160V|NFKBID_ENST00000352614.2_Missense_Mutation_p.A312V	NM_139239.1	NP_640332.1	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta	160					inflammatory response	nucleus				breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	14						GGCCAGGATGGCCGTGTGGAG	0.642000													10	106					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4827818	4827818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4827818C>T	ENST00000268231.8	-	10	1320	c.1057G>A	c.(1057-1059)Gat>Aat	p.D353N	SEPT12_ENST00000396693.5_Missense_Mutation_p.D307N	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	353					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						TCATCAGAATCGTCATGGGCC	0.662000													3	4					0	0	1	0	0
GLIPR1L1	256710	broad.mit.edu	37	12	75728596	75728596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:75728596G>A	ENST00000312442.2	+	1	134	c.88G>A	c.(88-90)Gac>Aac	p.D30N	CAPS2_ENST00000442339.2_Intron|GLIPR1L1_ENST00000378695.4_Missense_Mutation_p.D30N	NM_152779.2	NP_689992.1	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	30						extracellular region				endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10						ATCCATCACTGACCCACACTT	0.463000											OREG0021998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	67					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51864298	51864298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51864298C>T	ENST00000453097.2	+	13	1864	c.1647C>T	c.(1645-1647)ttC>ttT	p.F549F	SLC4A8_ENST00000394856.1_Silent_p.F496F|SLC4A8_ENST00000358657.3_Silent_p.F576F|SLC4A8_ENST00000514353.3_Silent_p.F496F|SLC4A8_ENST00000546663.1_3'UTR|SLC4A8_ENST00000535225.2_Silent_p.F496F	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	549					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		AGATTTTGTTCAAATTCTGCA	0.418000													30	129					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2432910	2432910	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2432910G>A	ENST00000452833.1	-	17	2576	c.2568C>T	c.(2566-2568)gcC>gcT	p.A856A	TRPM5_ENST00000155858.6_Silent_p.A854A|TRPM5_ENST00000533060.1_Silent_p.A854A|TRPM5_ENST00000528453.1_Silent_p.A854A			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	854						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCTTGTGTATGGCAAAGATAT	0.637000													35	64					0	0	1	0	0
MARCH5	54708	broad.mit.edu	37	10	94109519	94109519	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:94109519C>T	ENST00000358935.2	+	5	977	c.645C>T	c.(643-645)gtC>gtT	p.V215V	MARCH5_ENST00000467521.2_3'UTR	NM_017824.4	NP_060294.1	Q9NX47	MARH5_HUMAN	membrane-associated ring finger (C3HC4) 5	215					cell aging|protein autoubiquitination|protein localization in mitochondrion|protein polyubiquitination|regulation of mitochondrial fission	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	GTPase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GAGCCCTTGTCTTTCCTACTA	0.403000													95	175					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6756023	6756023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6756023C>T	ENST00000229243.2	-	2	292	c.199G>A	c.(199-201)Ggc>Agc	p.G67S	ACRBP_ENST00000536350.1_Missense_Mutation_p.G67S|ACRBP_ENST00000414226.2_Missense_Mutation_p.G67S	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	67						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						TTCCGGCAGCCGTGGGTTGCA	0.602000													21	39					0	0	1	0	0
C19orf55	148137	broad.mit.edu	37	19	36255778	36255778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36255778C>T	ENST00000544099.1	+	6	630	c.567C>T	c.(565-567)tcC>tcT	p.S189S	C19orf55_ENST00000396908.4_Silent_p.S189S			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	189										cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGAACTCATCCCTGCTGGACC	0.627000													8	32					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81205386	81205386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81205386C>T	ENST00000552864.1	-	5	762	c.560G>A	c.(559-561)cGa>cAa	p.R187Q		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	187	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						TGGGGTGTATCGCACCACCAG	0.483000													6	67					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171251235	171251235	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171251235A>C	ENST00000354841.4	+	6	1077	c.946A>C	c.(946-948)Act>Cct	p.T316P	FMO1_ENST00000402921.2_Missense_Mutation_p.T253P|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.T316P			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	316					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTTAACAATACTTCAAAGGA	0.418000													16	101					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103568561	103568561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:103568561C>T	ENST00000380069.3	+	2	577	c.501C>T	c.(499-501)acC>acT	p.T167T		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	167										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CCTCGCGCACCTTTGAGCAGG	0.662000													5	8					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49427388	49427388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49427388G>A	ENST00000301067.7	-	39	11099	c.11100C>T	c.(11098-11100)ttC>ttT	p.F3700F		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGTTGCCAGGGAAGAAGCCCC	0.582000													28	99					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41454959	41454959	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41454959G>A	ENST00000599198.1	+	0	1350					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TGCCCACAGGGAAGCGGATTT	0.572000													14	37					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110451248	110451248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:110451248G>A	ENST00000260283.4	-	16	2706	c.2422C>T	c.(2422-2424)Cct>Tct	p.P808S	ARHGAP20_ENST00000528829.1_Missense_Mutation_p.P772S|ARHGAP20_ENST00000524756.1_Missense_Mutation_p.P785S|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.P772S|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.P782S|ARHGAP20_ENST00000529591.1_Missense_Mutation_p.P351S|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.P782S	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	808					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GAGGACATAGGACTATAAGAT	0.458000													44	106					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18751216	18751216	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18751216G>A	ENST00000396170.1	-	13	2647	c.1383C>T	c.(1381-1383)atC>atT	p.I461I	PTPN5_ENST00000396171.4_Silent_p.I493I|PTPN5_ENST00000396167.2_Silent_p.I461I|PTPN5_ENST00000396166.3_Silent_p.I99I|PTPN5_ENST00000358540.2_Silent_p.I493I|PTPN5_ENST00000477854.1_Silent_p.I297I|RP11-1081L13.4_ENST00000527285.1_RNA|PTPN5_ENST00000396168.1_Silent_p.I469I	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	493	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						TGCAGTGGACGATGATGGGGG	0.746000													8	25					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228556048	228556048	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228556048C>T	ENST00000570156.2	+	99	22643	c.22569C>T	c.(22567-22569)gtC>gtT	p.V7523V	OBSCN_ENST00000366707.4_Silent_p.V4200V|OBSCN_ENST00000422127.1_Silent_p.V6566V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6566	Ig-like 55.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGTCAAGGTCTACATCCAGC	0.622000													3	8					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153026646	153026646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153026646C>T	ENST00000285900.5	+	3	722	c.379C>T	c.(379-381)Cct>Tct	p.P127S	GRIA1_ENST00000518142.1_Intron|GRIA1_ENST00000518862.1_3'UTR|GRIA1_ENST00000518783.1_Missense_Mutation_p.P137S|GRIA1_ENST00000521843.2_Missense_Mutation_p.P58S|GRIA1_ENST00000448073.4_Missense_Mutation_p.P137S|GRIA1_ENST00000340592.5_Missense_Mutation_p.P127S	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	127					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCAGCTGCGCCCTGAACTGCA	0.512000													20	139					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	72926360	72926360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:72926360G>A	ENST00000553530.1	+	6	570	c.363G>A	c.(361-363)tcG>tcA	p.S121S	RGS6_ENST00000434263.2_Silent_p.S52S|RGS6_ENST00000556437.1_Silent_p.S121S|RGS6_ENST00000343854.6_Silent_p.S121S|RGS6_ENST00000553690.1_3'UTR|RGS6_ENST00000402788.2_Silent_p.S121S|RGS6_ENST00000555571.1_Silent_p.S121S|RGS6_ENST00000406236.4_Silent_p.S121S|RGS6_ENST00000404301.2_Silent_p.S121S|RGS6_ENST00000553525.1_Silent_p.S121S|RGS6_ENST00000355512.6_Silent_p.S121S|RGS6_ENST00000407322.4_Silent_p.S121S	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	121					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		TCTGGCCTTCGAACTGCTGGG	0.572000													19	68					0	0	1	0	0
EHF	26298	broad.mit.edu	37	11	34680082	34680082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:34680082C>T	ENST00000257831.3	+	8	731	c.610C>T	c.(610-612)Ccg>Tcg	p.P204S	EHF_ENST00000530286.1_Missense_Mutation_p.P204S|EHF_ENST00000450654.2_Missense_Mutation_p.P181S|EHF_ENST00000531794.1_Missense_Mutation_p.P226S|EHF_ENST00000533754.1_Missense_Mutation_p.P204S	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	204					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TTCATCAGACCCGAGAGGGAC	0.463000													29	49					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39755817	39755817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39755817G>A	ENST00000442448.1	-	11	1168	c.897C>T	c.(895-897)ttC>ttT	p.F299F	ERG_ENST00000453032.2_Silent_p.F224F|ERG_ENST00000398907.1_Silent_p.F293F|ERG_ENST00000398911.1_Silent_p.F299F|ERG_ENST00000398919.2_Silent_p.F323F|ERG_ENST00000398905.1_Silent_p.F292F|ERG_ENST00000398910.1_Silent_p.F300F|ERG_ENST00000417133.2_Silent_p.F323F|ERG_ENST00000398897.1_Silent_p.F200F|ERG_ENST00000288319.7_Silent_p.F316F	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	323					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				GCTCCAGGAGGAACTGCCAAA	0.587000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								16	61					0	0	1	0	0
ISG20L2	81875	broad.mit.edu	37	1	156697137	156697137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156697137G>A	ENST00000313146.6	-	1	1090	c.308C>T	c.(307-309)cCt>cTt	p.P103L	ISG20L2_ENST00000368219.1_Missense_Mutation_p.P103L	NM_030980.1	NP_112242.1	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene 20kDa-like 2	103					ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGAAGGGGCAGGGGTCAACCA	0.517000											OREG0013885	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	85					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132471079	132471079	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:132471079C>T	ENST00000333577.4	+	7	2167	c.2058C>T	c.(2056-2058)ctC>ctT	p.L686L	EP400_ENST00000330386.6_Silent_p.L650L|EP400_ENST00000389562.2_Silent_p.L649L|EP400_ENST00000332482.4_Silent_p.L613L|EP400_ENST00000389561.2_Silent_p.L650L			Q96L91	EP400_HUMAN	E1A binding protein p400	686					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CGACAAGGCTCCCTGTGGACC	0.652000													43	68					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74635433	74635433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74635433C>T	ENST00000358632.4	-	5	1096	c.401G>A	c.(400-402)gGa>gAa	p.G134E	CYP11A1_ENST00000419019.2_Missense_Mutation_p.G134E|CYP11A1_ENST00000268053.6_Missense_Mutation_p.G292E|CYP11A1_ENST00000541301.1_3'UTR	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	292					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GTGAACACTTCCTTTCTGTCT	0.517000													76	83					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168180980	168180980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168180980C>T	ENST00000519560.1	-	17	2137	c.1718G>A	c.(1717-1719)cGa>cAa	p.R573Q	SLIT3_ENST00000332966.8_Missense_Mutation_p.R573Q|SLIT3_ENST00000404867.3_Missense_Mutation_p.R573Q	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	573					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCTCCCTCTCGCACCTCCTT	0.552000													6	15					0	0	1	0	0
FASTKD5	60493	broad.mit.edu	37	20	3129117	3129117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3129117G>A	ENST00000380266.3	-	2	921	c.600C>T	c.(598-600)ctC>ctT	p.L200L	UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000217173.2_Intron|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	200					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						GGGTATCAAAGAGCTGTATCT	0.463000													27	109					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882050	228882050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228882050G>A	ENST00000392056.3	-	7	3566	c.3520C>T	c.(3520-3522)Ctc>Ttc	p.L1174F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.L1174F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1174						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCACACTGAGGTGGTCACTT	0.527000													8	72					0	0	1	0	0
WNT11	7481	broad.mit.edu	37	11	75898246	75898246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75898246C>T	ENST00000322563.3	-	5	1052	c.928G>A	c.(928-930)Gac>Aac	p.D310N		NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	310					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						CACATAAGGTCGCAGCTGTCG	0.607000													22	41					0	0	1	0	0
TMEM45B	120224	broad.mit.edu	37	11	129722454	129722454	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:129722454C>T	ENST00000281441.3	+	2	165	c.77C>T	c.(76-78)cCg>cTg	p.P26L	TMEM45B_ENST00000524567.1_Missense_Mutation_p.P26L	NM_138788.3	NP_620143.1	Q96B21	TM45B_HUMAN	transmembrane protein 45B	26						integral to membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		GTGAAGTACCCGCTGAAGTAC	0.493000													13	105					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115439700	115439700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:115439700G>A	ENST00000393780.3	+	4	1264	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K	GAP43_ENST00000305124.6_Missense_Mutation_p.E230K	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	230					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		TAAAGAAGAGGAACCTGAGGC	0.507000													20	314					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60741964	60741964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:60741964G>A	ENST00000303375.5	+	2	576	c.174G>A	c.(172-174)caG>caA	p.Q58Q		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	58	Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						TGGAGGCCCAGGGCGGGCAGG	0.622000													35	93					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534203	92534203	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92534203C>T	ENST00000298047.6	+	9	8041	c.8024C>T	c.(8023-8025)tCg>tTg	p.S2675L	FAT3_ENST00000525166.1_Missense_Mutation_p.S2525L|FAT3_ENST00000409404.2_Missense_Mutation_p.S2675L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2675	Cadherin 24.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACAGTGCTTTCGTTCTTTGTC	0.483000										TCGA Ovarian(4;0.039)			15	32					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135346307	135346307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:135346307C>T	ENST00000463117.2	+	7	1032	c.760C>T	c.(760-762)Cat>Tat	p.H254Y	SPRN_ENST00000541506.1_Intron|CYP2E1_ENST00000252945.3_Missense_Mutation_p.H254Y			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	254					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	GAAGGAGCACCATCAATCTCT	0.522000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				35	93					0	0	1	0	0
FYCO1	79443	broad.mit.edu	37	3	46023068	46023068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46023068G>A	ENST00000296137.2	-	3	361	c.156C>T	c.(154-156)ctC>ctT	p.L52L	FYCO1_ENST00000535325.1_Silent_p.L52L	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	52	RUN.				transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		TTACTTGCAGGAGATACTCAA	0.418000													11	46					0	0	1	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44612310	44612310	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44612310C>T	ENST00000273320.3	+	6	2137	c.1708C>T	c.(1708-1710)Cag>Tag	p.Q570*	RP11-944L7.4_ENST00000457331.1_RNA|ZKSCAN7_ENST00000426540.1_Nonsense_Mutation_p.Q570*|ZKSCAN7_ENST00000431636.1_Intron|ZKSCAN7_ENST00000341840.3_Intron	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		TATTCGACATCAGAGCCTCCA	0.438000													32	101					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058656	9058656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9058656G>A	ENST00000397910.4	-	3	28993	c.28790C>T	c.(28789-28791)tCc>tTc	p.S9597F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9599	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCTCTGTGGATGAGGTGAT	0.527000													15	38					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160520779	160520779	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160520779C>T	ENST00000368054.3	-	5	842	c.807G>A	c.(805-807)agG>agA	p.R269R	CD84_ENST00000534968.1_Silent_p.R155R|CD84_ENST00000368051.3_Intron|CD84_ENST00000311224.4_Silent_p.R286R|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000368048.3_Silent_p.R280R	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	286					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GCTGGGTGTTCCTTGAAGCCA	0.443000													50	231					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28928094	28928094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:28928094G>A	ENST00000524189.1	-	40	5446	c.5408C>T	c.(5407-5409)tCg>tTg	p.S1803L	KIF13B_ENST00000404075.3_Missense_Mutation_p.S322L	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1803					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		AGCTGTCAGCGAGGCCAGGTT	0.706000													6	12					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50264894	50264894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50264894C>T	ENST00000284509.6	-	13	1269	c.1128G>A	c.(1126-1128)acG>acA	p.T376T	ATP8B4_ENST00000559829.1_Silent_p.T376T	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	376					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGAGCGTGGTCGTTCGAGCCA	0.418000													16	44					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230462	147230462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:147230462G>A	ENST00000271348.2	-	2	1046	c.885C>T	c.(883-885)aaC>aaT	p.N295N	GJA5_ENST00000369237.1_Silent_p.N295N|RP11-433J22.2_ENST00000428911.1_RNA	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	295					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CGGTGACCAGGTTGTCTGTGT	0.532000													31	133					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811137	23811137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23811137G>A	ENST00000314520.3	+	1	684	c.208G>A	c.(208-210)Gga>Aga	p.G70R	MKRN3_ENST00000568252.1_Missense_Mutation_p.G70R|MKRN3_ENST00000564592.1_Missense_Mutation_p.G70R	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	70						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CCTCCGCAGAGGAGGCCTGAG	0.657000													4	51					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4513637	4513637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4513637C>T	ENST00000301286.3	-	3	292	c.293G>A	c.(292-294)aGc>aAc	p.S98N		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	98	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						GTCCACCACGCTGGCCACCCC	0.637000													5	15					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76455287	76455287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76455287G>A	ENST00000389840.5	-	61	9739	c.9615C>T	c.(9613-9615)ccC>ccT	p.P3205P	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.P3214P					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGCCTTGGTAGGGCCTAGCGA	0.647000													54	158					0	0	1	0	0
C18orf25	147339	broad.mit.edu	37	18	43796275	43796275	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43796275C>T	ENST00000282059.6	+	2	803	c.429C>T	c.(427-429)tcC>tcT	p.S143S	C18orf25_ENST00000321319.6_Silent_p.S143S	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	143										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						CTAGGCGGTCCCGATCTGAAA	0.537000													7	100					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50813007	50813007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50813007C>T	ENST00000440075.2	+	43	6118	c.6071C>T	c.(6070-6072)tCc>tTc	p.S2024F	MYH14_ENST00000425460.1_Missense_Mutation_p.S1991F|MYH14_ENST00000262269.8_Missense_Mutation_p.S2024F|MYH14_ENST00000376970.2_Missense_Mutation_p.S2016F|MYH14_ENST00000598205.1_Missense_Mutation_p.S1991F|MYH14_ENST00000596571.1_Missense_Mutation_p.S1983F|MYH14_ENST00000601313.1_Missense_Mutation_p.S2024F			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1983					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		TCTGGGCCATCCCCGGAGCCT	0.682000													5	5					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100348964	100348964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100348964G>A	ENST00000437033.2	-	5	1033	c.530C>T	c.(529-531)tCc>tTc	p.S177F	ADH7_ENST00000209665.4_Missense_Mutation_p.S189F|ADH7_ENST00000482593.1_Missense_Mutation_p.S120F|ADH7_ENST00000476959.1_Missense_Mutation_p.S197F			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	189					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	ATATCCAGTGGAAAACCCACA	0.408000													19	43					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153190713	153190713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153190713C>T	ENST00000285900.5	+	16	2992	c.2649C>T	c.(2647-2649)ttC>ttT	p.F883F	GRIA1_ENST00000518142.1_Silent_p.F803F|GRIA1_ENST00000518783.1_Silent_p.F893F|GRIA1_ENST00000521843.2_Silent_p.F814F|GRIA1_ENST00000448073.4_Silent_p.F893F|GRIA1_ENST00000340592.5_Silent_p.F883F	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	883					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GCCATGACTTCCCCAAGTCCA	0.607000													39	32					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47941136	47941136	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:47941136C>T	ENST00000236877.6	-	7	2375	c.1980G>A	c.(1978-1980)gaG>gaA	p.E660E	SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000539381.1_Silent_p.E123E|SLC8A2_ENST00000542837.1_Silent_p.E416E	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	660					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CGATGATGACCTCCAGCCGGC	0.577000													36	98					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72344257	72344257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:72344257C>T	ENST00000299687.5	+	1	1282	c.1282C>T	c.(1282-1284)Cgt>Tgt	p.R428C	ZNF407_ENST00000309902.6_Missense_Mutation_p.R428C|ZNF407_ENST00000582337.1_Missense_Mutation_p.R428C|ZNF407_ENST00000577538.1_Missense_Mutation_p.R428C	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TAATAGCTTTCGTCGACGAAG	0.423000													15	81					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175409	51175409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51175409G>A	ENST00000440970.1	-	2	864	c.433C>T	c.(433-435)Cac>Tac	p.H145Y	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.H242Y	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	242					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGCAGCTGGTGGATCTGCTGC	0.547000													25	121					0	0	1	0	0
SH2D1B	117157	broad.mit.edu	37	1	162368760	162368760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:162368760G>A	ENST00000367929.2	-	3	425	c.316C>T	c.(316-318)Ccc>Tcc	p.P106S	SH2D1B_ENST00000359567.3_Intron	NM_053282.4	NP_444512.2	O14796	SH21B_HUMAN	SH2 domain containing 1B	106										kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			CTCAAGCTGGGGCTGGTTCTC	0.408000													34	73					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89953918	89953918	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89953918C>T	ENST00000405460.2	+	21	4671	c.4575C>T	c.(4573-4575)ttC>ttT	p.F1525F		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1525	Calx-beta 10.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACAAATCATTCATTATTTCTG	0.358000													36	94					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90770546	90770546	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:90770546G>A	ENST00000354366.3	-	5	970	c.738C>T	c.(736-738)ccC>ccT	p.P246P	NRDE2_ENST00000357904.3_Silent_p.P15P	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		GCTCAGATGAGGGAGGTTCAG	0.448000													43	119					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247597449	247597449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247597449C>T	ENST00000366497.2	+	6	3152	c.2372C>T	c.(2371-2373)tCc>tTc	p.S791F	NLRP3_ENST00000391828.3_Missense_Mutation_p.S791F|NLRP3_ENST00000336119.3_Missense_Mutation_p.S791F|NLRP3_ENST00000391827.2_Missense_Mutation_p.S734F|NLRP3_ENST00000348069.2_Missense_Mutation_p.S734F|NLRP3_ENST00000366496.2_Missense_Mutation_p.S791F	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	848					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TTCGACATCTCCTTGGTCCTC	0.567000													41	99					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848833	54848833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54848833G>A	ENST00000291759.4	-	5	846	c.790C>T	c.(790-792)Ccc>Tcc	p.P264S		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	264	Ig-like C2-type 3.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGGCGCTGGGGGAGGCCATCG	0.662000													21	24					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46771680	46771680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:46771680G>A	ENST00000394809.4	-	3	1059	c.944C>T	c.(943-945)cCt>cTt	p.P315L	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	315					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CAGCCCTGGAGGCCCTGGGCA	0.657000													30	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179474049	179474049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179474049C>T	ENST00000589042.1	-	273	52212	c.51988G>A	c.(51988-51990)Gga>Aga	p.G17330R	TTN_ENST00000342992.6_Missense_Mutation_p.G14762R|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G15689R|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G8457R|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G8390R|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G8265R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15689	Fibronectin type-III 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGATTCTCCCTTTTTGCTG	0.463000													10	51					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173596232	173596232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173596232C>T	ENST00000333279.2	-	4	623	c.563G>A	c.(562-564)gGa>gAa	p.G188E		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	204										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						TTTCCCTGATCCCTTTTCTGT	0.358000													31	114					0	0	1	0	0
TRIM7	81786	broad.mit.edu	37	5	180625718	180625718	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:180625718G>T	ENST00000393315.1	-	5	1033	c.336C>A	c.(334-336)gtC>gtA	p.V112V	TRIM7_ENST00000393319.3_Silent_p.V138V|CTC-338M12.6_ENST00000509080.1_RNA|TRIM7_ENST00000504241.1_5'UTR|TRIM7_ENST00000361809.3_Silent_p.V112V|TRIM7_ENST00000274773.7_Silent_p.V320V|CTC-338M12.6_ENST00000502812.2_RNA|CTC-338M12.6_ENST00000512508.1_RNA|TRIM7_ENST00000422067.2_Silent_p.V112V	NM_203296.1	NP_976041.1	Q9C029	TRIM7_HUMAN	tripartite motif containing 7	320						cytoplasm|nucleus	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|stomach(1)	17	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		TCCCTTTTAAGACAAAGGTCT	0.537000													12	53					6.72482e-11	6.75189e-11	1	1	0
MTTP	4547	broad.mit.edu	37	4	100504621	100504621	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:100504621G>A	ENST00000457717.1	+	4	596	c.340G>A	c.(340-342)Gaa>Aaa	p.E114K	MTTP_ENST00000511045.1_Missense_Mutation_p.E141K|MTTP_ENST00000265517.5_Missense_Mutation_p.E114K|MTTP_ENST00000422897.2_Missense_Mutation_p.E114K	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	114	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	AATGGGAAAGGAAAACTTGGA	0.393000													39	100					0	0	1	0	0
CYP24A1	1591	broad.mit.edu	37	20	52789509	52789509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:52789509C>T	ENST00000216862.3	-	2	781	c.388G>A	c.(388-390)Gag>Aag	p.E130K	CYP24A1_ENST00000395955.3_Missense_Mutation_p.E130K	NM_000782.4	NP_000773.2	Q07973	CP24A_HUMAN	cytochrome P450, family 24, subfamily A, polypeptide 1	130					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GGTTTGATCTCCAGCCGCTGC	0.622000													39	69					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53613787	53613787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:53613787G>A	ENST00000342160.3	-	37	5154	c.4697C>T	c.(4696-4698)cCc>cTc	p.P1566L	HUWE1_ENST00000262854.6_Missense_Mutation_p.P1566L|HUWE1_ENST00000218328.8_Missense_Mutation_p.P1566L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1566					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTGGAGGCAGGGCTGAACCAC	0.488000													12	22					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88485422	88485422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:88485422C>T	ENST00000324166.5	+	8	2926	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L	THNSL2_ENST00000343544.4_3'UTR|THNSL2_ENST00000358591.2_Missense_Mutation_p.P412L|THNSL2_ENST00000377254.3_Silent_p.S361S|THNSL2_ENST00000449349.1_Missense_Mutation_p.P238S|THNSL2_ENST00000496844.1_3'UTR	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	412					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						CACAGCACTCCCCGGTGCTGC	0.617000													4	9					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159912807	159912807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159912807G>A	ENST00000368094.1	-	3	390	c.193C>T	c.(193-195)Ccc>Tcc	p.P65S	IGSF9_ENST00000361509.3_Missense_Mutation_p.P65S	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	65	Ig-like 1.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGAAGATGGGAAGCAGGAAT	0.612000													13	51					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227915826	227915826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227915826C>T	ENST00000396625.3	-	33	3224	c.3017G>A	c.(3016-3018)aGa>aAa	p.R1006K	COL4A4_ENST00000329662.7_Missense_Mutation_p.R1006K	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1006	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGGTCCGTATCTTCCCGGCTC	0.547000													36	132					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650431	179650431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179650431G>A	ENST00000589042.1	-	15	2633	c.2409C>T	c.(2407-2409)gtC>gtT	p.V803V	TTN_ENST00000342992.6_Silent_p.V803V|TTN_ENST00000360870.5_Silent_p.V803V|TTN_ENST00000591111.1_Silent_p.V803V|TTN_ENST00000342175.6_Silent_p.V757V|TTN_ENST00000359218.5_Silent_p.V757V|TTN_ENST00000460472.2_Silent_p.V757V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	803							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCCACATGGACTAATCTTT	0.418000													34	98					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36995279	36995279	+	Silent	SNP	G	G	A	rs147433704		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36995279G>A	ENST00000274963.8	+	15	1851	c.1680G>A	c.(1678-1680)aaG>aaA	p.K560K		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	560	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						AGTGGGGCAAGAGCGGCCCCC	0.637000													27	133					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486595	125486595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125486595G>A	ENST00000259466.1	+	1	327	c.327G>A	c.(325-327)ggG>ggA	p.G109G		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						TGGCATTTGGGAACACTGACA	0.483000													9	140					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	657217	657217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:657217C>T	ENST00000266383.5	+	8	748	c.735C>T	c.(733-735)ttC>ttT	p.F245F	B4GALNT3_ENST00000544638.1_3'UTR	NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	245						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGTACTACTTCGAGGTGCTGC	0.642000													20	36					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18170851	18170851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18170851G>A	ENST00000600835.1	-	17	2139	c.1836C>T	c.(1834-1836)tcC>tcT	p.S612S	IL12RB1_ENST00000593993.1_Silent_p.S612S|IL12RB1_ENST00000430026.2_Silent_p.S612S			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	612					cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCTCCTGCAGGGATGCCTCTT	0.607000													3	17					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62758479	62758479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:62758479G>A	ENST00000512091.1	+	9	2129	c.1382G>A	c.(1381-1383)gGa>gAa	p.G461E	LPHN3_ENST00000504896.1_Missense_Mutation_p.G461E|LPHN3_ENST00000545650.1_Missense_Mutation_p.G461E|LPHN3_ENST00000507164.1_Missense_Mutation_p.G529E|LPHN3_ENST00000514157.1_Missense_Mutation_p.G461E|LPHN3_ENST00000511324.1_Missense_Mutation_p.G529E|LPHN3_ENST00000508693.1_Missense_Mutation_p.G529E|LPHN3_ENST00000506746.1_Missense_Mutation_p.G529E|LPHN3_ENST00000506700.1_Missense_Mutation_p.G461E|LPHN3_ENST00000514591.1_Missense_Mutation_p.G461E|LPHN3_ENST00000506720.1_Missense_Mutation_p.G529E|LPHN3_ENST00000509896.1_Missense_Mutation_p.G529E|LPHN3_ENST00000507625.1_Missense_Mutation_p.G529E|LPHN3_ENST00000508946.1_Missense_Mutation_p.G461E|LPHN3_ENST00000514996.1_Missense_Mutation_p.G461E			Q9HAR2	LPHN3_HUMAN	latrophilin 3	461					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TCAGTGTCAGGAAGAAGAAAC	0.542000													26	70					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79461839	79461839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79461839C>T	ENST00000264895.6	+	74	12040	c.11600C>T	c.(11599-11601)tCc>tTc	p.S3867F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3862					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTTGATGATTCCCTCATCTAT	0.552000													8	25					0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978303	10978303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10978303G>A	ENST00000240619.2	-	1	654	c.566C>T	c.(565-567)tCc>tTc	p.S189F		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	189					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						TGTAATTAGGGATAGTGTAAA	0.358000													32	64					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105645016	105645016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:105645016C>T	ENST00000542731.1	+	8	1043	c.935C>T	c.(934-936)tCc>tTc	p.S312F	CDHR3_ENST00000478080.1_Missense_Mutation_p.S224F|CDHR3_ENST00000470188.1_3'UTR|CDHR3_ENST00000541203.1_3'UTR|CDHR3_ENST00000317716.9_Missense_Mutation_p.S312F|CDHR3_ENST00000343407.5_Missense_Mutation_p.S29F			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	312	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CCCACCATTTCCCTGGAAGTT	0.483000													11	33					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25839905	25839905	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25839905G>A	ENST00000376351.3	+	6	1764	c.1404_splice	c.e6-1	p.V469_splice		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	469						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CATCCCACAGGTTGTTATTTT	0.408000													28	85					0	0	1	0	0
SDAD1	55153	broad.mit.edu	37	4	76879000	76879000	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76879000G>A	ENST00000356260.5	-	18	1696	c.1578_splice	c.e18+1	p.I526_splice	SDAD1_ENST00000395711.4_Splice_Site_p.I489_splice	NM_018115.2	NP_060585.2	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	526					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCAGACTTACGATTTCTTGCT	0.423000													58	127					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23398129	23398129	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23398129G>A	ENST00000379361.4	+	2	1633	c.773G>A	c.(772-774)aGg>aAg	p.R258K		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	258					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TCCTCACTGAGGGAAGATTTC	0.517000													84	46					0	0	1	0	0
TESC	54997	broad.mit.edu	37	12	117486949	117486949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117486949C>T	ENST00000335209.7	-	4	410	c.224G>A	c.(223-225)gGa>gAa	p.G75E	TESC_ENST00000392545.4_Missense_Mutation_p.G128E|TESC_ENST00000541210.1_Missense_Mutation_p.G48E|TESC_ENST00000535198.1_5'UTR			Q96BS2	TESC_HUMAN	tescalcin	75					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		GCCACTGGGTCCCTTGCGCAG	0.537000													17	71					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89949435	89949435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89949435G>A	ENST00000405460.2	+	20	4140	c.4044G>A	c.(4042-4044)agG>agA	p.R1348R		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1348					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATCCCTCCAGGAATAATACAA	0.448000													7	18					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67938308	67938308	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:67938308G>A	ENST00000252336.6	+	5	1684	c.1312G>A	c.(1312-1314)Gga>Aga	p.G438R	STARD8_ENST00000374597.3_Missense_Mutation_p.G438R|STARD8_ENST00000374599.3_Missense_Mutation_p.G518R	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	438					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						TGTGGAAGAAGGACACTCCAT	0.642000													16	8					0	0	1	0	0
ATL2	64225	broad.mit.edu	37	2	38525591	38525591	+	Missense_Mutation	SNP	G	G	A	rs116493165	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:38525591G>A	ENST00000378954.4	-	12	1328	c.1327C>T	c.(1327-1329)Cgt>Tgt	p.R443C	ATL2_ENST00000419554.2_Missense_Mutation_p.R443C|ATL2_ENST00000539122.1_Missense_Mutation_p.R272C|ATL2_ENST00000546051.1_Missense_Mutation_p.R272C|ATL2_ENST00000452935.2_Missense_Mutation_p.R425C|ATL2_ENST00000406122.1_Missense_Mutation_p.R272C|ATL2_ENST00000402054.1_Missense_Mutation_p.R272C|ATL2_ENST00000332337.4_Missense_Mutation_p.R425C	NM_001135673.1|NM_022374.2	NP_001129145.1|NP_071769.2	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2	443					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22						TCCTGATAACGACGGCAGAAC	0.418000													17	217					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207195413	207195413	+	Missense_Mutation	SNP	G	G	A	rs147463881		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207195413G>A	ENST00000359470.5	-	4	1945	c.1696C>T	c.(1696-1698)Cgt>Tgt	p.R566C	C1orf116_ENST00000461135.2_Missense_Mutation_p.R320C	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	566						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					AGCTTGTCACGGCTCTGTCCT	0.587000													16	43					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157650834	157650834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157650834G>A	ENST00000368184.3	-	12	2185	c.1894C>T	c.(1894-1896)Cct>Tct	p.P632S	FCRL3_ENST00000368186.5_Missense_Mutation_p.P632S|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	632						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GGCTCTTGAGGGTCTATCCTG	0.542000													16	36					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131522171	131522171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131522171C>T	ENST00000423981.1	+	2	2636	c.2526C>T	c.(2524-2526)ctC>ctT	p.L842L	AMER3_ENST00000321420.4_Silent_p.L842L	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GTGAGGGCCTCCTCTGTGGCC	0.627000													8	14					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324651	79324651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79324651C>T	ENST00000428286.1	-	8	2662	c.1462G>A	c.(1462-1464)Gaa>Aaa	p.E488K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E847K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	847					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCCAGTAGTTCTGAAGAAGAA	0.463000													11	28					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127796962	127796962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:127796962C>T	ENST00000556132.1	-	6	3073	c.2209G>A	c.(2209-2211)Gac>Aac	p.D737N	SOGA3_ENST00000368268.2_Missense_Mutation_p.D737N|SOGA3_ENST00000525778.1_Missense_Mutation_p.D737N|SOGA3_ENST00000481848.2_Missense_Mutation_p.D737N|SOGA3_ENST00000465909.2_Missense_Mutation_p.D737N	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	737						integral to membrane											GAGGCCAGGTCGTAGCGCTGC	0.677000													54	50					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24959159	24959159	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24959159T>A	ENST00000396432.2	-	3	717	c.231A>T	c.(229-231)caA>caT	p.Q77H		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	76	PDZ.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TATATGAAAATTGAATTGCAG	0.398000													28	49					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124407	142124407	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142124407G>A	ENST00000390376.2	-	0	70																											TGGGGTCTGAGTGACACCAGC	0.532000													30	50					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61555329	61555329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61555329C>T	ENST00000290866.4	+	2	311	c.287C>T	c.(286-288)gCc>gTc	p.A96V	ACE_ENST00000584529.1_3'UTR|ACE_ENST00000428043.1_Missense_Mutation_p.A96V|ACE_ENST00000538928.1_Missense_Mutation_p.A96V	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	96	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TTTGCGGAGGCCTGGGGCCAG	0.622000													11	18					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516686	140516686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140516686C>T	ENST00000231134.5	+	1	1887	c.1670C>T	c.(1669-1671)tCg>tTg	p.S557L		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		557	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACGACAACTCGCCCTTCGTG	0.716000													30	59					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460392	107460392	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107460392G>A	ENST00000409382.3	-	2	652	c.42C>T	c.(40-42)ttC>ttT	p.F14F	ST6GAL2_ENST00000409087.3_Silent_p.F14F|ST6GAL2_ENST00000361686.4_Silent_p.F14F	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	14					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CGAATATTCCGAAAAGCATTC	0.512000													23	55					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31286729	31286729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31286729G>A	ENST00000332585.6	+	8	1742	c.1638G>A	c.(1636-1638)gaG>gaA	p.E546E	OSBP2_ENST00000407373.1_Silent_p.E373E|OSBP2_ENST00000535268.1_Silent_p.E90E|OSBP2_ENST00000382310.3_Silent_p.E497E|OSBP2_ENST00000437268.2_Silent_p.E288E|OSBP2_ENST00000401475.1_Silent_p.E179E|OSBP2_ENST00000403222.3_Silent_p.E380E|OSBP2_ENST00000446658.2_Silent_p.E545E	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	546					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						ACTTCAATGAGCCCCTGTCCA	0.612000											OREG0026467	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	37					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38830220	38830220	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38830220G>A	ENST00000359357.3	+	42	5899	c.5645G>A	c.(5644-5646)gGa>gAa	p.G1882E	DNAH8_ENST00000441566.1_Missense_Mutation_p.G1882E|DNAH8_ENST00000449981.2_Missense_Mutation_p.G2099E					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGAGGCCTAGGAAGGATTTTC	0.348000													40	91					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110466201	110466201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110466201G>A	ENST00000329608.6	+	6	1349	c.958G>A	c.(958-960)Ggg>Agg	p.G320R	CSF1_ENST00000369801.1_Missense_Mutation_p.G320R|CSF1_ENST00000344188.5_Missense_Mutation_p.G320R|CSF1_ENST00000369802.3_Missense_Mutation_p.G320R|CSF1_ENST00000420111.2_Intron	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	320					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGTACCCCAAGGGACAGAGCT	0.587000											OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	77					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70946574	70946574	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70946574C>T	ENST00000334414.6	-	21	5414	c.5370G>A	c.(5368-5370)aaG>aaA	p.K1790K	PTPRB_ENST00000550358.1_Silent_p.K1702K|PTPRB_ENST00000261266.5_Silent_p.K1572K|PTPRB_ENST00000451516.2_Silent_p.K1482K|PTPRB_ENST00000538708.1_Silent_p.K1482K|PTPRB_ENST00000550857.1_Silent_p.K1482K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1572	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CAGTGTGTGGCTTCAGTGGTC	0.453000													13	47					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034117	52034117	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52034117C>T	ENST00000346477.3	-	3	592	c.524G>A	c.(523-525)gGg>gAg	p.G175E	SIGLEC6_ENST00000391797.3_Missense_Mutation_p.G164E|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.G139E|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.G175E|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.G175E|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.G175E	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	175	Ig-like C2-type 1.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GGGGGGCGTCCCCTGCTCACA	0.667000													41	101					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61542375	61542375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61542375G>A	ENST00000266070.4	-	3	915	c.590C>T	c.(589-591)cCc>cTc	p.P197L	DIDO1_ENST00000395340.1_Missense_Mutation_p.P197L|DIDO1_ENST00000370366.1_Missense_Mutation_p.P197L|DIDO1_ENST00000354665.4_Missense_Mutation_p.P197L|DIDO1_ENST00000395343.1_Missense_Mutation_p.P197L|DIDO1_ENST00000370371.4_Missense_Mutation_p.P197L|DIDO1_ENST00000370368.1_Missense_Mutation_p.P197L|DIDO1_ENST00000395335.2_Missense_Mutation_p.P197L|DIDO1_ENST00000266071.5_Missense_Mutation_p.P197L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	197					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					AGTCTCGGCGGGACCCTCCTC	0.657000													28	35					0	0	1	0	0
PANX1	24145	broad.mit.edu	37	11	93911540	93911540	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93911540C>T	ENST00000227638.3	+	3	712	c.327C>T	c.(325-327)ttC>ttT	p.F109F	PANX1_ENST00000436171.2_Silent_p.F109F	NM_015368.3	NP_056183.2	Q96RD7	PANX1_HUMAN	pannexin 1	109					positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding			endometrium(2)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTCAGTTTTTCCCCTACATCC	0.478000													15	64					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116429355	116429355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:116429355G>A	ENST00000281928.3	-	17	3610	c.3404C>T	c.(3403-3405)gCc>gTc	p.A1135V		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1135					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CATGTTGCAGGCACAGATGCA	0.483000													37	60					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121745926	121745926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:121745926G>A	ENST00000452319.1	+	14	2496	c.2436G>A	c.(2434-2436)acG>acA	p.T812T	GLI2_ENST00000361492.4_Silent_p.T812T|GLI2_ENST00000314490.11_Silent_p.T484T			P10070	GLI2_HUMAN	GLI family zinc finger 2	812	Ser-rich.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCACCAGCACGGTCAGCTCGG	0.746000													9	17					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109937499	109937499	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109937499C>T	ENST00000342494.3	+	12	1597	c.1002C>T	c.(1000-1002)ttC>ttT	p.F334F	UBE3B_ENST00000280774.5_Silent_p.F334F|UBE3B_ENST00000434735.2_Silent_p.F334F	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	334					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CAGATGGGTTCGTGAGTTTGC	0.557000													8	36					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1443182	1443182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:1443182G>A	ENST00000446702.2	+	21	3397	c.2770G>A	c.(2770-2772)Gag>Aag	p.E924K	CNTN6_ENST00000539053.1_Missense_Mutation_p.E852K|CNTN6_ENST00000350110.2_Missense_Mutation_p.E924K			Q9UQ52	CNTN6_HUMAN	contactin 6	924	Fibronectin type-III 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CTTGAACTGGGAGCATGTAAA	0.353000													14	58					0	0	1	0	0
ALDOB	229	broad.mit.edu	37	9	104189916	104189916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104189916C>T	ENST00000374855.4	-	5	512	c.388G>A	c.(388-390)Ggc>Agc	p.G130S	ALDOB_ENST00000468981.2_Intron	NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	130					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				TCTGAGAGGCCATCAAGCCCT	0.507000													30	51					0	0	1	0	0
GRINA	2907	broad.mit.edu	37	8	145065532	145065532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145065532C>T	ENST00000313269.5	+	2	419	c.141C>T	c.(139-141)ttC>ttT	p.F47F	GRINA_ENST00000395068.4_Silent_p.F47F	NM_000837.1	NP_000828.1	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	47	Pro-rich.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	9	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGCCCCCTTTCCAGCCCTCCC	0.706000													3	19					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778532	31778532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31778532C>T	ENST00000375654.4	-	2	1407	c.1218G>A	c.(1216-1218)gaG>gaA	p.E406E	HSPA1L_ENST00000417199.3_Silent_p.E406E	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	406					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						CCCCAGCCGTCTCCAGCCCCA	0.607000													22	108					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271762	22271762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22271762G>A	ENST00000594947.1	+	4	1354	c.1210G>A	c.(1210-1212)Gaa>Aaa	p.E404K		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				CAAATGTGATGAATATTGCAA	0.393000													16	25					0	0	1	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067213	18067213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18067213C>T	ENST00000506618.2	-	1	273	c.193G>A	c.(193-195)Gac>Aac	p.D65N		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	65					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					ATTAGACTGTCGTTGATTTCG	0.478000													120	286					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24344800	24344800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24344800C>T	ENST00000175238.6	+	11	1144	c.1061C>T	c.(1060-1062)tCa>tTa	p.S354L	ADAM7_ENST00000380789.1_Missense_Mutation_p.S354L|ADAM7_ENST00000520720.1_Missense_Mutation_p.S126L|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	354	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ACCTGTCCTTCAGGAAAATGC	0.458000													16	28					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116960807	116960807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:116960807C>T	ENST00000265441.3	-	2	423	c.124G>A	c.(124-126)Gat>Aat	p.D42N	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	42					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GGCACATTATCGCACATCACC	0.592000													3	23					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88478074	88478074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:88478074G>A	ENST00000267549.3	+	2	1441	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	295					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TTTTGTAACCGAAACAGGAAG	0.353000													10	55					0	0	1	0	0
SOCS5	9655	broad.mit.edu	37	2	46986807	46986807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:46986807C>T	ENST00000306503.5	+	2	1310	c.1138C>T	c.(1138-1140)Ccc>Tcc	p.P380S	SOCS5_ENST00000394861.2_Missense_Mutation_p.P380S	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	380					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TACAGGGAATCCCTGTTACTG	0.498000													17	50					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28659848	28659848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28659848C>T	ENST00000280904.6	-	11	2071	c.1628G>A	c.(1627-1629)gGc>gAc	p.G543D	DSC2_ENST00000251081.6_Missense_Mutation_p.G543D	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	543	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			ATTATATATGCCATTTTTGAT	0.388000													65	161					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622674	38622674	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38622674G>A	ENST00000413689.1	-	17	3169	c.2976C>T	c.(2974-2976)ccC>ccT	p.P992P	SCN5A_ENST00000423572.2_Silent_p.P992P|SCN5A_ENST00000425664.1_Silent_p.P992P|SCN5A_ENST00000333535.4_Silent_p.P992P|SCN5A_ENST00000451551.2_Silent_p.P992P|SCN5A_ENST00000455624.2_Silent_p.P992P|SCN5A_ENST00000449557.2_Silent_p.P992P|SCN5A_ENST00000450102.2_Silent_p.P992P|SCN5A_ENST00000443581.1_Silent_p.P992P|SCN5A_ENST00000414099.2_Silent_p.P992P	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	992					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CAAGGGCTGCGGGCTTCTGAG	0.687000													6	14					0	0	1	0	0
WNT5A	7474	broad.mit.edu	37	3	55504230	55504230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:55504230C>T	ENST00000474267.1	-	6	1554	c.1033G>A	c.(1033-1035)Gac>Aac	p.D345N	WNT5A_ENST00000497027.1_Missense_Mutation_p.D330N|WNT5A_ENST00000264634.4_Missense_Mutation_p.D345N			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	345					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		TTGAACTGGTCGTAGCCACGG	0.617000													25	81					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	128829926	128829926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:128829926C>T	ENST00000280333.6	+	17	1683	c.1574C>T	c.(1573-1575)tCt>tTt	p.S525F		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	525	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		AAGGATAAATCTGAGAAAATA	0.348000													34	83					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934796	113934796	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113934796G>A	ENST00000335953.4	+	2	1154	c.774G>A	c.(772-774)ggG>ggA	p.G258G	ZBTB16_ENST00000392996.2_Silent_p.G258G	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	258					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		ACAGCCCTGGGGCAGCCGAGT	0.647000													15	18					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46989702	46989702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46989702C>T	ENST00000371253.2	-	6	759	c.544G>A	c.(544-546)Gaa>Aaa	p.E182K	GPR110_ENST00000371243.2_Missense_Mutation_p.E182K|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	182	SEA.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						ACTTGAATTTCAATTCCATTT	0.294000													30	69					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876232	35876232	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35876232G>A	ENST00000303115.3	+	8	1153	c.1024G>A	c.(1024-1026)Ggg>Agg	p.G342R	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	342					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GAGGCTTGGAGGGGATGTGCA	0.488000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						17	41					0	0	1	0	0
CSN1S1	1446	broad.mit.edu	37	4	70810643	70810643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70810643C>T	ENST00000246891.4	+	15	527	c.478C>T	c.(478-480)Cct>Tct	p.P160S	CSN1S1_ENST00000444405.3_Missense_Mutation_p.P151S|CSN1S1_ENST00000507772.1_Missense_Mutation_p.P152S|CSN1S1_ENST00000505782.1_Missense_Mutation_p.P144S|CSN1S1_ENST00000507763.1_Missense_Mutation_p.P151S	NM_001890.1	NP_001881.1	P47710	CASA1_HUMAN	casein alpha s1	160						extracellular region	protein binding|transporter activity			lung(5)|prostate(1)|upper_aerodigestive_tract(1)	7						GCAGTATGTTCCTTTCCCACC	0.408000													84	226					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783315	54783315	+	Silent	SNP	G	G	A	rs143879306	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54783315G>A	ENST00000391748.1	-	5	670	c.543C>T	c.(541-543)ttC>ttT	p.F181F	LILRB2_ENST00000391746.1_Silent_p.F181F|LILRB2_ENST00000314446.5_Silent_p.F181F|LILRB2_ENST00000434421.1_Silent_p.F65F|LILRB2_ENST00000391749.4_Silent_p.F181F	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	181	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGCCCACGGAGAAGATGGCGC	0.577000													23	127					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124393810	124393810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124393810C>T	ENST00000409039.3	+	57	9489	c.9464C>T	c.(9463-9465)tCg>tTg	p.S3155L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3155	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTTGCCAGGTCGTTTGCTAAG	0.542000													13	18					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103143635	103143635	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103143635G>A	ENST00000428762.1	-	52	8476	c.8317C>T	c.(8317-8319)Caa>Taa	p.Q2773*	RELN_ENST00000424685.2_Nonsense_Mutation_p.Q2773*|RELN_ENST00000343529.5_Nonsense_Mutation_p.Q2773*|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2773					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACATGAATTTGATTCTGGGCA	0.383000													9	91					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49866927	49866927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49866927G>A	ENST00000331456.2	-	14	1364	c.1251C>T	c.(1249-1251)ttC>ttT	p.F417F	TRAIP_ENST00000469027.1_Silent_p.F262F	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	417	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CGAGCCCATCGAAGCCTGTCC	0.562000													20	50					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71730343	71730343	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71730343G>A	ENST00000258104.3	+	4	513		c.e4-1		DYSF_ENST00000410041.1_Splice_Site|DYSF_ENST00000429174.2_Splice_Site|DYSF_ENST00000409744.1_Splice_Site|DYSF_ENST00000410020.3_Splice_Site|DYSF_ENST00000394120.2_Splice_Site|DYSF_ENST00000409366.1_Splice_Site|DYSF_ENST00000409582.3_Splice_Site|DYSF_ENST00000413539.2_Splice_Site|DYSF_ENST00000409651.1_Splice_Site|DYSF_ENST00000409762.1_Splice_Site	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin							cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TCTCCTCTCAGGTTCCTGGGG	0.597000													63	168					0	0	1	0	0
MCM5	4174	broad.mit.edu	37	22	35813759	35813759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:35813759C>T	ENST00000216122.4	+	13	1767	c.1613C>T	c.(1612-1614)aCt>aTt	p.T538I	MCM5_ENST00000382011.5_Missense_Mutation_p.T495I	NM_006739.3	NP_006730.2	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	538					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29						CATGTCATCACTCTGCACGTG	0.577000													51	106					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77288529	77288529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77288529C>T	ENST00000388914.3	-	11	1900	c.1748G>A	c.(1747-1749)cGa>cAa	p.R583Q		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	583								p.R583Q(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						TCCAGCAGTTCGTCCATGCTG	0.458000													33	76					0	0	1	0	0
CHST6	4166	broad.mit.edu	37	16	75513171	75513171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:75513171G>A	ENST00000332272.4	-	3	735	c.556C>T	c.(556-558)Ccg>Tcg	p.P186S	CHST6_ENST00000390664.2_Missense_Mutation_p.P186S|RP11-77K12.4_ENST00000530512.3_RNA	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	186					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CTGAGCAGCGGGTAGAGCACC	0.701000													21	66					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87392992	87392992	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:87392992C>T	ENST00000517970.1	+	4	415	c.108C>T	c.(106-108)ttC>ttT	p.F36F	WWP1_ENST00000341922.2_Silent_p.F36F|WWP1_ENST00000349423.2_Intron|WWP1_ENST00000523863.1_3'UTR|WWP1_ENST00000265428.4_Silent_p.F36F	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	36	C2.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						AGAACTGGTTCGGAACAGCAA	0.348000													9	38					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655992	19655992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19655992C>T	ENST00000586018.1	+	8	2758	c.2656C>T	c.(2656-2658)Ccg>Tcg	p.P886S	CILP2_ENST00000291495.4_Missense_Mutation_p.P880S			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	880						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GCCTGTGTACCCGTGGCGCAG	0.677000													19	35					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118997858	118997858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:118997858C>T	ENST00000328252.3	+	7	3043	c.2674C>T	c.(2674-2676)Cct>Tct	p.P892S	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	892					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GGTCCGGGACCCTCCTCTCCA	0.507000													10	94					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131923622	131923622	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131923622C>T	ENST00000378823.3	+	7	1293	c.475C>T	c.(475-477)Caa>Taa	p.Q159*	RAD50_ENST00000487596.1_3'UTR|RAD50_ENST00000265335.6_Nonsense_Mutation_p.Q298*	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	298					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACAGGTTTTTCAAGGGACTGA	0.323000								Homologous recombination					25	55					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25785868	25785868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25785868C>T	ENST00000399878.3	-	14	2384	c.2262G>A	c.(2260-2262)atG>atA	p.M754I	SEL1L3_ENST00000502949.1_Missense_Mutation_p.M601I|SEL1L3_ENST00000264868.5_Missense_Mutation_p.M719I	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	754						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						CTGCTTTCTTCATCAGCTCTA	0.443000													80	145					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86249817	86249817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86249817G>A	ENST00000370571.2	-	50	4566	c.4200C>T	c.(4198-4200)ttC>ttT	p.F1400F	COL24A1_ENST00000436319.1_Silent_p.F1400F	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1400	Collagen-like 16.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GGAATCCTTGGAAACCTGTCA	0.358000													28	76					0	0	1	0	0
ARRDC5	645432	broad.mit.edu	37	19	4896717	4896717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4896717C>T	ENST00000381781.2	-	2	466	c.467G>A	c.(466-468)gGa>gAa	p.G156E		NM_001080523.1	NP_001073992.1	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	156					signal transduction					endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		GGTGGAAGTTCCTTGAACCAA	0.488000													20	38					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486995	125486995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125486995G>A	ENST00000259466.1	+	1	727	c.727G>A	c.(727-729)Ggc>Agc	p.G243S		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						CTCTACCTGTGGCTCCCACCT	0.537000													33	148					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704941	52704941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:52704941C>T	ENST00000287727.3	+	4	2024	c.1852C>T	c.(1852-1854)Ctt>Ttt	p.L618F	ZFYVE9_ENST00000371591.1_Missense_Mutation_p.L618F|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.L618F|ZFYVE9_ENST00000361625.1_Missense_Mutation_p.L618F	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	618					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AAATGATATTCTTGGGAAAGC	0.328000													12	117					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87445462	87445462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:87445462G>A	ENST00000268616.4	-	12	2671	c.2454C>T	c.(2452-2454)tcC>tcT	p.S818S		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	818					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		AGGTGAACACGGACGGACCGG	0.652000													3	11					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118596651	118596651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:118596651G>A	ENST00000336338.5	-	20	2853	c.2788C>T	c.(2788-2790)Cct>Tct	p.P930S		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	930						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AAAATGAAAGGAATCTTTTCC	0.313000													6	36					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323399	79323399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79323399G>A	ENST00000428286.1	-	8	3914	c.2714C>T	c.(2713-2715)tCc>tTc	p.S905F	PRUNE2_ENST00000376718.3_Missense_Mutation_p.S1264F			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1264					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CGCATCTGGGGAATGAGTGTC	0.478000													16	29					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141773915	141773915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141773915C>T	ENST00000475668.2	+	45	5271	c.5217C>T	c.(5215-5217)gcC>gcT	p.A1739A	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1739	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTATTATTGCCCTAGATGAAA	0.433000													13	39					0	0	1	0	0
IFLTD1	160492	broad.mit.edu	37	12	25702421	25702421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25702421G>A	ENST00000282881.6	-	2	235	c.86C>T	c.(85-87)tCa>tTa	p.S29L	IFLTD1_ENST00000445693.1_Intron|IFLTD1_ENST00000458174.2_Missense_Mutation_p.S50L|IFLTD1_ENST00000413632.2_Missense_Mutation_p.S50L|IFLTD1_ENST00000539744.1_5'UTR	NM_152590.3	NP_689803.2	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	29						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TGTGGCAACTGAACCCAACAT	0.333000													25	94					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104164482	104164482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104164482C>T	ENST00000020673.5	-	15	3084	c.2558G>A	c.(2557-2559)aGc>aAc	p.S853N	PSD_ENST00000406432.1_Missense_Mutation_p.S853N	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	853	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CTGCTCCAGGCTCCTGGGGAG	0.557000													33	126					0	0	1	0	0
TTLL9	164395	broad.mit.edu	37	20	30507699	30507699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30507699C>T	ENST00000375938.4	+	7	790	c.537C>T	c.(535-537)ctC>ctT	p.L179L	TTLL9_ENST00000375921.2_Intron|TTLL9_ENST00000535842.1_Silent_p.L179L|TTLL9_ENST00000310998.4_Silent_p.L129L|TTLL9_ENST00000375922.4_Intron|TTLL9_ENST00000375934.4_Silent_p.L161L			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	179	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GCATCTTCCTCTTCCGTAGGC	0.622000													35	62					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38484966	38484966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38484966C>T	ENST00000263409.4	-	18	2664	c.2502G>A	c.(2500-2502)gtG>gtA	p.V834V	LIFR_ENST00000453190.2_Silent_p.V834V	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	834					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TAATTAATCCCACAGCTGAAA	0.368000			T	PLAG1	salivary adenoma								7	35					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81702197	81702197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81702197C>T	ENST00000372292.3	-	4	420	c.380G>A	c.(379-381)gGg>gAg	p.G127E		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	127	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TCCTATGTTCCCCTGCTTCCC	0.592000													17	41					0	0	1	0	0
SPOPL	339745	broad.mit.edu	37	2	139326544	139326544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:139326544C>T	ENST00000280098.4	+	11	1452	c.1073C>T	c.(1072-1074)tCc>tTc	p.S358F		NM_001001664.2	NP_001001664.1	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	358						nucleus				breast(2)|cervix(2)|endometrium(2)|large_intestine(2)|lung(11)|skin(2)	21				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GGGTGGAAGTCCATGATTCAG	0.408000													102	267					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52536041	52536041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52536041G>A	ENST00000321725.6	+	4	427	c.351G>A	c.(349-351)gaG>gaA	p.E117E		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	117	EGF-like 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGGGCGCTGAGACCCCATGCA	0.637000													14	43					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40768415	40768415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40768415G>A	ENST00000372748.3	-	30	1766	c.1670C>T	c.(1669-1671)cCt>cTt	p.P557L	COL9A2_ENST00000466267.1_5'UTR	NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	557	Triple-helical region 2 (COL2).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			AGGTCCTGGAGGACCCATCAT	0.701000													4	9					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82625885	82625885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:82625885C>T	ENST00000533655.1	+	3	317	c.105C>T	c.(103-105)gtC>gtT	p.V35V	C11orf82_ENST00000525361.1_Silent_p.V35V|C11orf82_ENST00000329143.3_5'UTR|C11orf82_ENST00000525388.1_Silent_p.V35V|C11orf82_ENST00000430323.2_Silent_p.V35V|C11orf82_ENST00000528759.1_Silent_p.V35V|C11orf82_ENST00000524921.1_Silent_p.V35V	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	35					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TAATCCTGGTCTCCAAAAGGT	0.393000													13	39					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41725620	41725620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41725620C>T	ENST00000400454.1	-	5	1183	c.706G>A	c.(706-708)Gcc>Acc	p.A236T		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	236	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCAGCCATGGCTTTGCGATGG	0.547000													14	22					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124596525	124596525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124596525G>A	ENST00000368904.1	-	7	1588	c.639C>T	c.(637-639)gcC>gcT	p.A213A	CUZD1_ENST00000392790.1_Silent_p.A213A|CUZD1_ENST00000545804.1_Silent_p.A213A			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	213	CUB 2.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CATCATAGATGGCAAGAAAAT	0.443000													17	46					0	0	1	0	0
PDGFC	56034	broad.mit.edu	37	4	157771398	157771398	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:157771398C>T	ENST00000502773.1	-	2	779	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K	PDGFC_ENST00000542208.1_5'UTR|PDGFC_ENST00000541126.1_Intron|PDGFC_ENST00000422544.2_Missense_Mutation_p.E97K	NM_016205.2	NP_057289.1	Q9NRA1	PDGFC_HUMAN	platelet derived growth factor C	97	CUB.				central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		TCTGGGTCTTCAAGCCCAAAT	0.348000													19	57					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39089647	39089647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39089647G>A	ENST00000379907.4	+	15	1754	c.1627G>A	c.(1627-1629)Gga>Aga	p.G543R	ADAM32_ENST00000437682.2_Missense_Mutation_p.G444R|ADAM32_ENST00000519315.1_Missense_Mutation_p.G437R	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	543					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGTGTTCTGTGGATGGAGGTA	0.338000													15	73					0	0	1	0	0
LIPJ	142910	broad.mit.edu	37	10	90356112	90356112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:90356112C>T	ENST00000371939.3	+	7	829	c.515C>T	c.(514-516)tCc>tTc	p.S172F		NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J	172					lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		CCAGTTTTTTCCACAAAGTAC	0.254000													15	37					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186115002	186115002	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:186115002C>T	ENST00000271588.4	+	93	14784	c.14555C>T	c.(14554-14556)cCc>cTc	p.P4852L	HMCN1_ENST00000367492.2_Missense_Mutation_p.P4852L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4852	TSP type-1 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GGTGGCCGTCCCTGTCCCGGA	0.537000													16	63					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97045391	97045391	+	Nonsense_Mutation	SNP	G	G	A	rs78760556		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:97045391G>A	ENST00000524981.3	+	3	251	c.251G>A	c.(250-252)tGg>tAg	p.W84*				Q6ZTY8	CL063_HUMAN		58										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GGTGGCTATTGGACTCTGCTT	0.383000													49	73					0	0	1	0	0
ACTC1	70	broad.mit.edu	37	15	35084718	35084718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:35084718C>T	ENST00000290378.4	-	4	1162	c.507G>A	c.(505-507)gaG>gaA	p.E169E	RP11-814P5.1_ENST00000503496.1_RNA|ACTC1_ENST00000557860.1_5'UTR	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	169					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AAGCGTAGCCCTCATAGATGG	0.532000													11	86					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94129588	94129588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:94129588C>T	ENST00000243673.2	-	2	661	c.490G>A	c.(490-492)Gcc>Acc	p.A164T	GPR83_ENST00000539203.2_Intron	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	164						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ACCGCAATGGCTGTCAGTGTC	0.557000													20	50					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60703555	60703555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60703555C>T	ENST00000005286.4	+	11	2404	c.2251C>T	c.(2251-2253)Cgg>Tgg	p.R751W	TMEM132A_ENST00000453848.2_Missense_Mutation_p.R750W	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	750	Binds to HSPA5/GRP78 (By similarity).|Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GCCCTGCCGCCGGGGCCGCCA	0.746000													4	22					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29429491	29429491	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29429491G>A	ENST00000377136.1	+	0	410				OR2H1_ENST00000377133.1_De_novo_Start_OutOfFrame|OR2H1_ENST00000442615.1_De_novo_Start_OutOfFrame|OR2H1_ENST00000396792.2_De_novo_Start_OutOfFrame|OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377132.1_De_novo_Start_OutOfFrame			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						GATAAGACAGGTTGAATCACA	0.527000													19	45					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171482205	171482205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171482205C>T	ENST00000367742.3	+	3	426	c.184C>T	c.(184-186)Ctc>Ttc	p.L62F	PRRC2C_ENST00000426496.2_Missense_Mutation_p.L60F|PRRC2C_ENST00000338920.4_Missense_Mutation_p.L60F|PRRC2C_ENST00000392078.3_Missense_Mutation_p.L62F|PRRC2C_ENST00000476522.1_3'UTR			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	60							protein C-terminus binding										ACCTGCTAACCTCCCAAGTCT	0.418000													12	49					0	0	1	0	0
GTPBP4	23560	broad.mit.edu	37	10	1046704	1046704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:1046704C>T	ENST00000360803.4	+	7	824	c.742C>T	c.(742-744)Cgt>Tgt	p.R248C	GTPBP4_ENST00000545048.1_Missense_Mutation_p.R201C|GTPBP4_ENST00000491635.1_3'UTR|GTPBP4_ENST00000538293.1_Missense_Mutation_p.R132C	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	248					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		GGCCCACCTCCGTGCTGCGGT	0.557000													38	71					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66931444	66931444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:66931444G>A	ENST00000374690.3	+	4	2610	c.2086G>A	c.(2086-2088)Gac>Aac	p.D696N	AR_ENST00000396044.3_Missense_Mutation_p.D696N|AR_ENST00000396043.2_Missense_Mutation_p.D164N	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	695	Interaction with MYST2.|Ligand-binding.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CAACCAGCCCGACTCCTTTGC	0.527000									Androgen Insensitivity Syndrome				9	24					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70922888	70922888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70922888C>T	ENST00000264436.3	-	6	964	c.520G>A	c.(520-522)Gga>Aga	p.G174R	ADD2_ENST00000413157.2_Missense_Mutation_p.G174R|ADD2_ENST00000407644.2_Missense_Mutation_p.G174R|ADD2_ENST00000355733.3_Missense_Mutation_p.G174R|ADD2_ENST00000430656.1_Missense_Mutation_p.G190R	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	174					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding	p.G174R(2)		autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CAAGAAACTCCCTTAGGGCTG	0.517000													8	31					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43976494	43976494	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43976494G>A	ENST00000262726.7	-	25	3331	c.3078C>T	c.(3076-3078)ttC>ttT	p.F1026F	EFCAB6_ENST00000396231.2_Silent_p.F874F	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1026					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CTGCTCTCAGGAAGTCGAGGT	0.458000													107	267					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086479	100086479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100086479G>A	ENST00000423930.1	+	4	1294	c.1135G>A	c.(1135-1137)Gag>Aag	p.E379K	NYAP1_ENST00000454988.1_Missense_Mutation_p.E322K|NYAP1_ENST00000300179.2_Missense_Mutation_p.E379K			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	379	Pro-rich.																GCCTGCACGGGAGCGGGAGAC	0.701000													24	50					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55958861	55958861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55958861C>T	ENST00000263923.4	-	22	3287	c.2992G>A	c.(2992-2994)Gac>Aac	p.D998N		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	998	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTCAGGAAGTCCTTATACAGA	0.448000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			15	52					0	0	1	0	0
OR1I1	126370	broad.mit.edu	37	19	15198724	15198724	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15198724C>T	ENST00000209540.2	+	1	934	c.848C>T	c.(847-849)cCc>cTc	p.P283L		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						GTGTTCATCCCCATGCTCAAC	0.562000													14	73					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47332457	47332457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47332457G>A	ENST00000398879.1	-	26	4185	c.3819C>T	c.(3817-3819)gcC>gcT	p.A1273A	TNS3_ENST00000311160.9_Silent_p.A1273A|TNS3_ENST00000355730.3_Silent_p.A1033A			Q68CZ2	TENS3_HUMAN	tensin 3	1273	SH2.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TGCACGGCAAGGCCAAGGGCG	0.537000													16	59					0	0	1	0	0
IGFL2	147920	broad.mit.edu	37	19	46663672	46663672	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46663672C>T	ENST00000434646.2	+	3	344	c.52_splice	c.e3-1	p.A18_splice	IGFL2_ENST00000600243.1_3'UTR|IGFL2_ENST00000377693.4_Splice_Site_p.A7_splice|AC007193.6_ENST00000597989.1_lincRNA	NM_001002915.2	NP_001002915.2	Q6UWQ7	IGFL2_HUMAN	IGF-like family member 2	7						extracellular region	protein binding			cervix(1)|lung(5)	6		Ovarian(192;0.0908)|all_neural(266;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(486;0.031)|Epithelial(262;0.247)		TCTCTCCCAGCTCCTGCTTAT	0.542000													5	18					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45946460	45946460	+	Silent	SNP	C	C	T	rs138534271	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45946460C>T	ENST00000348697.2	+	14	1809	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F	FBLN1_ENST00000476366.1_3'UTR|FBLN1_ENST00000402984.3_Silent_p.F592F|FBLN1_ENST00000327858.6_Silent_p.F554F|FBLN1_ENST00000340923.5_Silent_p.F554F|FBLN1_ENST00000442170.2_Silent_p.F554F|FBLN1_ENST00000262722.7_Silent_p.F554F			P23142	FBLN1_HUMAN	fibulin 1	554	EGF-like 9; calcium-binding.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GCCTGGCCTTCGAGTGCCCTG	0.592000													12	80					0	0	1	0	0
UBA1	7317	broad.mit.edu	37	X	47060944	47060944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:47060944C>T	ENST00000335972.6	+	8	929	c.746C>T	c.(745-747)tCc>tTc	p.S249F	UBA1_ENST00000377351.4_Missense_Mutation_p.S249F	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	249	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GACTTTGTCTCCTTTTCAGAA	0.547000													28	12					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20506951	20506951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20506951G>A	ENST00000202677.6	-	28	3780	c.3638C>T	c.(3637-3639)tCc>tTc	p.S1213F		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	1213					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						CTCCCAGTAGGAAACCAGCAA	0.408000													4	36					0	0	1	0	0
C9orf9	11092	broad.mit.edu	37	9	135759460	135759460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135759460C>T	ENST00000372136.3	+	2	573	c.126C>T	c.(124-126)ccC>ccT	p.P42P	C9orf9_ENST00000356311.5_Silent_p.P42P|C9orf9_ENST00000350499.6_Silent_p.P42P			Q96E40	CI009_HUMAN	chromosome 9 open reading frame 9	42								p.?(1)		cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		AGATCCGGCCCATCTCCAGCA	0.632000													7	53					0	0	1	0	0
MRPS31	10240	broad.mit.edu	37	13	41331094	41331094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:41331094G>A	ENST00000323563.6	-	4	691	c.655C>T	c.(655-657)Cgt>Tgt	p.R219C		NM_005830.3	NP_005821.2	Q92665	RT31_HUMAN	mitochondrial ribosomal protein S31	219						mitochondrion|ribosome	protein domain specific binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)		GGTCTTGAACGAACTCTAGCT	0.373000													26	77					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156815774	156815774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156815774C>T	ENST00000368195.3	-	9	2344	c.1948G>A	c.(1948-1950)Gac>Aac	p.D650N	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	650	Fibronectin type-III 2.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGGTAGAGGTCGCCGTCCTCT	0.706000													15	26					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656465	19656465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19656465G>A	ENST00000586018.1	+	8	3231	c.3129G>A	c.(3127-3129)ccG>ccA	p.P1043P	CILP2_ENST00000291495.4_Silent_p.P1037P			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1037						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						ACCCCCCACCGGTGCCCGCGG	0.667000													5	16					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63005497	63005497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:63005497G>A	ENST00000251157.5	-	26	3145	c.3112C>T	c.(3112-3114)Cca>Tca	p.P1038S	DOCK7_ENST00000340370.5_Missense_Mutation_p.P1007S	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1038					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						AAACGTTCTGGAAAACGACTT	0.348000													25	45					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54951462	54951462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54951462C>T	ENST00000173898.7	+	6	1558	c.1446C>T	c.(1444-1446)ttC>ttT	p.F482F	TRO_ENST00000375022.4_Silent_p.F482F|TRO_ENST00000375041.2_Silent_p.F85F|TRO_ENST00000399736.1_Silent_p.F85F|TRO_ENST00000420798.2_Silent_p.F13F|TRO_ENST00000484031.1_3'UTR|TRO_ENST00000319167.8_Silent_p.F482F	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	482	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						ATGAATATTTCCCAGAAATCA	0.502000													15	10					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154105	5154105	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5154105C>T	ENST00000252321.3	+	1	1021	c.792C>T	c.(790-792)atC>atT	p.I264I		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	264						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TCATCTCCATCATCACCTTCT	0.647000													20	147					0	0	1	0	0
EIF2AK2	5610	broad.mit.edu	37	2	37366820	37366820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37366820G>A	ENST00000233057.4	-	6	792	c.470C>T	c.(469-471)gCc>gTc	p.A157V	EIF2AK2_ENST00000405334.1_Missense_Mutation_p.A157V|EIF2AK2_ENST00000395127.2_Missense_Mutation_p.A157V	NM_001135651.2	NP_001129123.1	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 2	157	DRBM 2.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)	22		all_hematologic(82;0.248)				AAGTTTAGCGGCCAATTGTTT	0.333000													38	127					0	0	1	0	0
MYL3	4634	broad.mit.edu	37	3	46899877	46899877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46899877C>T	ENST00000395869.1	-	5	607	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K	MYL3_ENST00000292327.4_Missense_Mutation_p.E186K			P08590	MYL3_HUMAN	myosin, light chain 3, alkali; ventricular, skeletal, slow	186	EF-hand 3.				cardiac muscle contraction|muscle filament sliding|positive regulation of ATPase activity|regulation of striated muscle contraction|regulation of the force of heart contraction|ventricular cardiac muscle tissue morphogenesis	A band|cytosol|I band|muscle myosin complex	actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			breast(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(193;0.00116)|KIRC - Kidney renal clear cell carcinoma(197;0.00557)|Kidney(197;0.0063)		AGCCCACCTTCATAGTTGATG	0.602000													15	62					0	0	1	0	0
ERP27	121506	broad.mit.edu	37	12	15090909	15090909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15090909C>T	ENST00000266397.2	-	2	745	c.172G>A	c.(172-174)Gtg>Atg	p.V58M		NM_152321.2	NP_689534.1	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27	58	Thioredoxin.					endoplasmic reticulum lumen				breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(3)|prostate(2)|skin(1)	19						ATGACAGCCACCTCAGTGGCA	0.532000													33	143					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99566032	99566032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99566032C>T	ENST00000411734.1	-	3	355	c.350G>A	c.(349-351)aGg>aAg	p.R117K	AZGP1_ENST00000292401.4_Missense_Mutation_p.R120K			P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	120					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					ACAACCAAACCTTCCCTGCAA	0.433000													40	410					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885902	24885902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24885902C>T	ENST00000382554.3	+	9	5265	c.4947C>T	c.(4945-4947)ttC>ttT	p.F1649F		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1649	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TGGAGGCATTCCCCCTGAAGC	0.602000													12	49					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26514727	26514727	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26514727G>A	ENST00000531191.1	+	16	1690	c.683G>A	c.(682-684)tGg>tAg	p.W228*	CNKSR1_ENST00000361530.6_Nonsense_Mutation_p.W486*|CNKSR1_ENST00000374253.5_Nonsense_Mutation_p.W493*			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	493	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging	p.W486*(1)		breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCATAGGTGGGTGCGTCAT	0.572000													24	34					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182555890	182555890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:182555890C>T	ENST00000367559.3	-	2	305	c.52G>A	c.(52-54)Ggt>Agt	p.G18S	RNASEL_ENST00000539397.1_Missense_Mutation_p.G18S|RNASEL_ENST00000444138.1_Missense_Mutation_p.G18S	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	18					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						GCCCTTCTACCGCTGGAGGAC	0.498000													17	149					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26093564	26093564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26093564G>A	ENST00000313735.6	-	19	2451	c.2218C>T	c.(2218-2220)Cgg>Tgg	p.R740W		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	740	FAD-binding FR-type.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGATTCTGCCGAGATTTGAGC	0.478000													29	101					0	0	1	0	0
CFHR2	3080	broad.mit.edu	37	1	196918671	196918671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196918671G>A	ENST00000367415.4	+	2	259	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	CFHR2_ENST00000476712.1_3'UTR|CFHR2_ENST00000367421.3_Missense_Mutation_p.E49K	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	49	Sushi 1.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						TCCTACAGGGGAAGTTTTCTA	0.363000													27	58					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142612675	142612675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142612675C>T	ENST00000265310.1	-	9	1534	c.1186G>A	c.(1186-1188)Gct>Act	p.A396T		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	396					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					ATGATCACAGCCCCAACGATG	0.537000													9	41					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14613922	14613922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14613922C>T	ENST00000544627.1	+	9	2996	c.2676C>T	c.(2674-2676)gcC>gcT	p.A892A	ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000536444.1_Silent_p.A883A|ATF7IP_ENST00000543189.1_Silent_p.A883A|ATF7IP_ENST00000540793.1_Silent_p.A884A|ATF7IP_ENST00000261168.4_Silent_p.A884A			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	884					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TTGTACAAGCCACAAGGACTT	0.458000													7	32					0	0	1	0	0
CLEC2L	154790	broad.mit.edu	37	7	139225185	139225185	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139225185C>T	ENST00000422142.2	+	3	456	c.384C>T	c.(382-384)tgC>tgT	p.C128C		NM_001080511.2	NP_001073980.2	P0C7M8	CLC2L_HUMAN	C-type lectin domain family 2, member L	128	C-type lectin.					integral to membrane	sugar binding			NS(1)|endometrium(1)|kidney(2)|lung(1)	5	Melanoma(164;0.233)					GGCAGTACTGCCACACCCACG	0.622000													10	6					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255045	15255045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15255045C>T	ENST00000378116.4	-	8	2548	c.2542G>A	c.(2542-2544)Gcc>Acc	p.A848T		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	848						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TGGGGGCTGGCTGCTGGCTCC	0.607000													69	130					0	0	1	0	0
PSMC3	5702	broad.mit.edu	37	11	47447451	47447451	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47447451G>A	ENST00000298852.3	-	2	283	c.126C>T	c.(124-126)atC>atT	p.I42I	PSMC3_ENST00000530912.1_Silent_p.I42I|PSMC3_ENST00000602866.1_Silent_p.I26I	NM_002804.4	NP_002795.2	P17980	PRS6A_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 3	42					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(4)|urinary_tract(1)	17				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GTGTGCGCTGGATGATCTCCT	0.532000													27	69					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862824	10862824	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10862824C>T	ENST00000559480.1	+	0	120																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						TGAAGGTCTCCTGCAAGGCTT	0.577000													27	177					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106215	55106215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55106215C>T	ENST00000453777.1	+	4	326	c.156C>T	c.(154-156)atC>atT	p.I52I	LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000251372.3_Silent_p.I52I|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	52	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GTCAGGGGATCCTGGAGACCC	0.577000													36	101					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120584894	120584894	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120584894G>A	ENST00000300648.6	-	38	4921	c.4909C>T	c.(4909-4911)Cag>Tag	p.Q1637*		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1637					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAATAATCTGGGCTGCCATC	0.552000													4	30					0	0	1	0	0
INPP5J	27124	broad.mit.edu	37	22	31521797	31521797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31521797C>T	ENST00000331075.5	+	2	1121	c.1072C>T	c.(1072-1074)Cgc>Tgc	p.R358C	INPP5J_ENST00000400294.2_Intron|INPP5J_ENST00000412277.2_Missense_Mutation_p.R291C|INPP5J_ENST00000405300.1_Intron|INPP5J_ENST00000404390.3_Intron			Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J	358	Pro-rich.					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	12						CTCCCCGAATCGCTCTCCCTG	0.687000													4	10					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154684136	154684136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:154684136G>A	ENST00000404039.1	+	26	2939	c.2352G>A	c.(2350-2352)agG>agA	p.R784R	DPP6_ENST00000427557.1_Silent_p.R741R|DPP6_ENST00000377770.3_Silent_p.R848R|DPP6_ENST00000332007.3_Silent_p.R786R	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	848					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AATGCTTCAGGATCCAGGACA	0.502000													51	99					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124810354	124810354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124810354G>A	ENST00000423114.2	-	12	1936	c.1937C>T	c.(1936-1938)aCc>aTc	p.T646I	SLC12A8_ENST00000465475.1_Intron|SLC12A8_ENST00000314584.7_Intron|SLC12A8_ENST00000393469.4_Missense_Mutation_p.T617I|SLC12A8_ENST00000469902.1_Missense_Mutation_p.T617I|SLC12A8_ENST00000430155.2_Missense_Mutation_p.T418I			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	617					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						GTTAACCAGGGTATACACCCA	0.488000													21	52					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62178550	62178550	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62178550G>A	ENST00000217188.1	-	1	307	c.267C>T	c.(265-267)ttC>ttT	p.F89F		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	89	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GCCTGCGTGCGAAGATGTAGC	0.672000													14	41					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4873157	4873157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4873157G>A	ENST00000252318.2	+	9	1874	c.1537G>A	c.(1537-1539)Gga>Aga	p.G513R		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	513	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CTTGGATCAGGGACCCGTTCC	0.502000													42	85					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89265922	89265922	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89265922G>A	ENST00000464162.1	-	0	238																											ATGCAGCATAGATCAGGAGCT	0.517000													104	198					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984913	41984913	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41984913C>T	ENST00000333141.5	+	1	1201	c.1104C>T	c.(1102-1104)ttC>ttT	p.F368F		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	368										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						GCGTGGCCTTCGCTTCTCGGC	0.607000													33	50					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129207226	129207226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129207226G>A	ENST00000296266.3	+	17	2323	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	IFT122_ENST00000440957.2_Missense_Mutation_p.E451K|IFT122_ENST00000431818.2_Missense_Mutation_p.E510K|IFT122_ENST00000504021.1_Missense_Mutation_p.E554K|IFT122_ENST00000349441.2_Missense_Mutation_p.E549K|IFT122_ENST00000347300.2_Missense_Mutation_p.E601K|IFT122_ENST00000507564.1_Missense_Mutation_p.E652K|IFT122_ENST00000348417.2_Missense_Mutation_p.E660K	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	660					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TTTAGATTTTGAAACAGCAAA	0.517000													14	58					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236925843	236925843	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236925843C>T	ENST00000366578.4	+	21	2775	c.2609C>T	c.(2608-2610)tCg>tTg	p.S870L	ACTN2_ENST00000542672.1_Missense_Mutation_p.S870L|ACTN2_ENST00000546208.1_Missense_Mutation_p.S364L	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	870					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CCCGCCTACTCGGGCCCAGGC	0.587000													11	55					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99655367	99655367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99655367C>T	ENST00000292450.4	+	3	610	c.446C>T	c.(445-447)tCc>tTc	p.S149F	ZSCAN21_ENST00000456748.2_Missense_Mutation_p.S149F|ZSCAN21_ENST00000477297.1_3'UTR|ZSCAN21_ENST00000543588.1_Missense_Mutation_p.S149F	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	149					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GAGAAGATATCCTCCTCAGGA	0.517000													28	61					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124846820	124846820	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124846820G>A	ENST00000356219.3	-	23	3104	c.2949C>T	c.(2947-2949)ccC>ccT	p.P983P	NCOR2_ENST00000404121.2_Silent_p.P537P|NCOR2_ENST00000405201.1_Silent_p.P984P|NCOR2_ENST00000404621.1_Silent_p.P966P|NCOR2_ENST00000429285.2_Silent_p.P966P|NCOR2_ENST00000397355.1_Silent_p.P967P	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	984					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCTCCCGGGGGGGCTCATGGA	0.647000													6	11					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26681985	26681985	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26681985G>A	ENST00000256737.3	+	27	3792	c.2940G>A	c.(2938-2940)tgG>tgA	p.W980*	ANO3_ENST00000537978.1_Nonsense_Mutation_p.W964*|ANO3_ENST00000525139.1_Nonsense_Mutation_p.W964*|ANO3_ENST00000531568.1_Nonsense_Mutation_p.W834*	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	980						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						ACCATGAATGGCCTTAGTTGA	0.418000													26	86					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61533565	61533565	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61533565C>T	ENST00000278836.5	+	3	366	c.270C>T	c.(268-270)ctC>ctT	p.L90L	MYRF_ENST00000265460.5_Silent_p.L81L	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		ATGGTCCCCTCCCACCCCCGG	0.736000													12	26					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699043	52699043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52699043C>T	ENST00000293525.5	+	5	807	c.755C>T	c.(754-756)tCc>tTc	p.S252F	KRT86_ENST00000544024.1_Missense_Mutation_p.S252F|KRT86_ENST00000423955.2_Missense_Mutation_p.S252F	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	252	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		GTTCTCCAGTCCCACATCTCA	0.552000													21	130					0	0	1	0	0
NUMBL	9253	broad.mit.edu	37	19	41186939	41186939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41186939G>A	ENST00000252891.4	-	6	590	c.423C>T	c.(421-423)atC>atT	p.I141I	NUMBL_ENST00000540131.1_Silent_p.I100I|NUMBL_ENST00000598779.1_Silent_p.I100I	NM_004756.3	NP_004747.1	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	141	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)	16			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			AGACCTTTTCGATGGTCTGGT	0.537000													60	121					0	0	1	0	0
CEP63	80254	broad.mit.edu	37	3	134256002	134256002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134256002C>T	ENST00000337090.3	+	6	620	c.447C>T	c.(445-447)ttC>ttT	p.F149F	CEP63_ENST00000354446.3_Silent_p.F149F|CEP63_ENST00000332047.5_Silent_p.F149F|CEP63_ENST00000606977.1_Silent_p.F149F|CEP63_ENST00000383229.3_Silent_p.F149F|CEP63_ENST00000513612.2_Silent_p.F149F			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	149					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CTCAGGAATTCCGTCAGAAAT	0.463000													31	68					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42513902	42513902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42513902G>A	ENST00000591680.1	-	4	235	c.205C>T	c.(205-207)Ccc>Tcc	p.P69S	GPATCH8_ENST00000434000.1_5'UTR|GPATCH8_ENST00000586265.1_5'UTR	NM_001002909.2	NP_001002909.1	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	69	G-patch.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ATTGGAATGGGATCTGTTCTC	0.403000													14	31					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10428436	10428436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10428436G>A	ENST00000293677.6	-	12	2135	c.2054C>T	c.(2053-2055)tCc>tTc	p.S685F	CTD-2369P2.12_ENST00000586529.1_Missense_Mutation_p.S86F	NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	512						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CCCCAGCGGGGAAGAGCCGAT	0.697000													4	14					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144886117	144886117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:144886117G>A	ENST00000369359.4	-	26	3566	c.3528C>T	c.(3526-3528)ttC>ttT	p.F1176F	PDE4DIP_ENST00000369354.3_Silent_p.F1039F|PDE4DIP_ENST00000313382.9_Silent_p.F1105F|PDE4DIP_ENST00000530740.1_Silent_p.F1176F|PDE4DIP_ENST00000369356.4_Silent_p.F1039F|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1039					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ACACTGAGGAGAATCCTGCTT	0.547000			T	PDGFRB	MPD								23	109					0	0	1	0	0
KRT18	3875	broad.mit.edu	37	12	53343040	53343040	+	Missense_Mutation	SNP	C	C	T	rs74379840		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53343040C>T	ENST00000550600.1	+	2	137	c.83C>T	c.(82-84)cCg>cTg	p.P28L	KRT8_ENST00000546897.1_Intron|KRT18_ENST00000388837.2_Missense_Mutation_p.P28L|KRT8_ENST00000549198.1_Intron|KRT18_ENST00000388835.3_Missense_Mutation_p.P28L|KRT8_ENST00000552551.1_Intron			P05783	K1C18_HUMAN	keratin 18	28	Head.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						GGCGCCCGGCCGGTCAGCAGC	0.697000													46	94					0	0	1	0	0
NR2E3	10002	broad.mit.edu	37	15	72105971	72105971	+	RNA	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72105971A>G	ENST00000398840.2	+	0	1179							Q9Y5X4	NR2E3_HUMAN	nuclear receptor subfamily 2, group E, member 3						phototransduction|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|endometrium(1)|lung(1)	3						GTCCTCTTCAAGCCAGGTAAC	0.567000													11	67					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73834126	73834126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73834126G>A	ENST00000334126.7	-	8	1498	c.1272C>T	c.(1270-1272)tcC>tcT	p.S424S	C2CD3_ENST00000313663.7_Silent_p.S424S			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	424						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					CAGGAGATGGGGAATCTGGAG	0.428000													18	53					0	0	1	0	0
MFSD7	84179	broad.mit.edu	37	4	680390	680390	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:680390G>A	ENST00000322224.4	-	2	538	c.225C>T	c.(223-225)taC>taT	p.Y75Y	MFSD7_ENST00000347950.5_Silent_p.Y53Y|MFSD7_ENST00000513740.1_5'UTR|MFSD7_ENST00000503156.1_Silent_p.Y11Y|MFSD7_ENST00000515118.1_Silent_p.Y75Y|MFSD7_ENST00000404286.2_Silent_p.Y75Y			Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing 7	75					transmembrane transport	integral to membrane				cervix(1)|kidney(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	11						ATACCACGAGGTAGACCAGTG	0.627000													24	79					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21715852	21715852	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21715852C>T	ENST00000261195.2	-	7	1316	c.1062_splice	c.e7+1	p.R354_splice		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	354					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GCTTTCTTACCCTCAGCAGGA	0.383000													24	156					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36755299	36755299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36755299C>T	ENST00000354618.5	+	5	1903	c.1679C>T	c.(1678-1680)tCc>tTc	p.S560F	THRAP3_ENST00000469141.2_Missense_Mutation_p.S560F	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	560					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGAAAGTCTTCCTTTTCCATT	0.502000			T	USP6	aneurysmal bone cysts								28	100					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57187685	57187685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57187685G>A	ENST00000331162.4	-	5	1707	c.1437C>T	c.(1435-1437)acC>acT	p.T479T		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GTTGCATAAGGGTTGAGGAGC	0.403000													11	101					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36779912	36779912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36779912G>A	ENST00000416516.2	-	2	729	c.239C>T	c.(238-240)cCc>cTc	p.P80L		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	80						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						AAGCTCCTCGGGGATCTTCCC	0.612000													74	171					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77662426	77662426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77662426G>A	ENST00000296043.6	+	5	4053	c.3100G>A	c.(3100-3102)Gag>Aag	p.E1034K		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1034					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GATCGTGGAGGAGGCCGAACC	0.692000													7	36					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228481217	228481217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228481217C>T	ENST00000570156.2	+	46	12392	c.12318C>T	c.(12316-12318)gcC>gcT	p.A4106A	OBSCN_ENST00000366707.4_Silent_p.A796A|OBSCN_ENST00000422127.1_Silent_p.A3677A|OBSCN_ENST00000284548.11_Silent_p.A3677A|OBSCN_ENST00000366709.4_Silent_p.A796A|OBSCN_ENST00000359599.6_Silent_p.A2524A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3148	Ig-like 42.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGACGGGGCCAGGTGTGAGC	0.647000													35	56					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45399639	45399639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45399639C>T	ENST00000389039.6	-	14	1982	c.1597G>A	c.(1597-1599)Gaa>Aaa	p.E533K	DUOX2_ENST00000603300.1_Missense_Mutation_p.E533K			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	533	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CGGATGTCTTCAATCTCCTTC	0.552000													42	102					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32474867	32474867	+	Missense_Mutation	SNP	C	C	T	rs150636128		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:32474867C>T	ENST00000404025.2	-	5	2554	c.2066G>A	c.(2065-2067)aGc>aAc	p.S689N	NLRC4_ENST00000360906.5_Missense_Mutation_p.S689N|NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Missense_Mutation_p.S689N			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	689					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAGCCTGAGGCTTGTGGCAGA	0.468000													34	92					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204953175	204953175	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204953175G>A	ENST00000367172.4	+	22	2819	c.2491G>A	c.(2491-2493)Gaa>Aaa	p.E831K	NFASC_ENST00000513543.1_Missense_Mutation_p.E827K|NFASC_ENST00000338586.6_Missense_Mutation_p.E831K|NFASC_ENST00000367169.4_Intron|NFASC_ENST00000360049.4_Missense_Mutation_p.E827K|NFASC_ENST00000367171.4_Missense_Mutation_p.E816K|NFASC_ENST00000401399.1_Intron|NFASC_ENST00000539706.1_Missense_Mutation_p.E827K|NFASC_ENST00000367170.4_Missense_Mutation_p.E831K|NFASC_ENST00000339876.6_Intron|NFASC_ENST00000404907.1_Missense_Mutation_p.E827K|NFASC_ENST00000404076.1_Missense_Mutation_p.E810K|NFASC_ENST00000338515.6_Missense_Mutation_p.E831K			O94856	NFASC_HUMAN	neurofascin	831	Fibronectin type-III 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGCGCCCACTGAAGTTAAAGT	0.557000													7	46					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142626553	142626553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142626553G>A	ENST00000265310.1	-	4	805	c.457C>T	c.(457-459)Cgc>Tgc	p.R153C	TRPV5_ENST00000442623.1_Missense_Mutation_p.R153C	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	153					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GGACTACGGCGGAAGGCAGTG	0.617000													32	74					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4923295	4923295	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4923295G>A	ENST00000320785.5	+	19	2028	c.1671G>A	c.(1669-1671)gtG>gtA	p.V557V	AC109333.10_ENST00000438266.1_RNA|KIF1C_ENST00000573815.1_3'UTR	NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	557	FHA.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						ATTCAGTGGTGGTCACTCTGG	0.527000													8	5					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96447569	96447569	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96447569C>T	ENST00000285979.6	+	2	410	c.211C>T	c.(211-213)Ctg>Ttg	p.L71L	CYP2C18_ENST00000339022.5_Silent_p.L71L	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GTATTTTGGCCTGAAGCCCAT	0.418000													29	249					0	0	1	0	0
PPAP2A	8611	broad.mit.edu	37	5	54771130	54771130	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:54771130G>A	ENST00000307259.8	-	2	627	c.207C>T	c.(205-207)atC>atT	p.I69I	PPAP2A_ENST00000515132.1_Intron|PPAP2A_ENST00000264775.5_Intron	NM_003711.2	NP_003702.2	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A	69					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	9		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				AACTTACAACGATAATACTGA	0.338000													10	17					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36017667	36017667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36017667C>T	ENST00000452271.2	-	1	1545	c.1517G>A	c.(1516-1518)gGa>gAa	p.G506E	SBSN_ENST00000518157.1_Missense_Mutation_p.G163E	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	163						extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CACTTCCTTTCCAGCCTGGTC	0.592000													10	89					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30307468	30307468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:30307468G>A	ENST00000361371.4	-	27	4988	c.4838C>T	c.(4837-4839)tCt>tTt	p.S1613F	LTN1_ENST00000389194.2_Missense_Mutation_p.S1659F	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	1613							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						TGTTTGTACAGAAGATATTTC	0.343000													26	62					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395053	49395053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49395053G>A	ENST00000419783.1	-	2	701	c.380C>T	c.(379-381)gCc>gTc	p.A127V	GPX1_ENST00000419349.1_3'UTR|GPX1_ENST00000496791.1_5'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	127					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CCGCAGGAAGGCGAAGAGAGG	0.632000													27	51					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38655202	38655202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38655202C>T	ENST00000222345.6	+	15	4373	c.3864C>T	c.(3862-3864)ttC>ttT	p.F1288F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1288					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACCGCTGGTTCGACCCCCTGG	0.607000													9	93					0	0	1	0	0
OR51A2	401667	broad.mit.edu	37	11	4976080	4976080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4976080C>T	ENST00000380371.1	-	1	863	c.864G>A	c.(862-864)atG>atA	p.M288I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004748.1	NP_001004748.1	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A, member 2	288			M -> T (in dbSNP:rs2442426).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAATTGGTTTCATCAGCGGAG	0.418000													38	64					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152831474	152831474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152831474G>A	ENST00000367255.5	-	8	1036	c.435C>T	c.(433-435)ctC>ctT	p.L145L	SYNE1_ENST00000466159.2_Silent_p.L145L|SYNE1_ENST00000413186.2_Silent_p.L145L|SYNE1_ENST00000448038.1_Silent_p.L152L|SYNE1_ENST00000367253.4_Silent_p.L145L|SYNE1_ENST00000367248.3_Silent_p.L152L|SYNE1_ENST00000423061.1_Silent_p.L152L|SYNE1_ENST00000265368.4_Silent_p.L145L|SYNE1_ENST00000341594.5_Silent_p.L145L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	145	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACAAAGACTGGAGCTGGGGCA	0.458000										HNSCC(10;0.0054)			22	22					0	0	1	0	0
NPS	594857	broad.mit.edu	37	10	129350866	129350866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129350866G>A	ENST00000398023.1	+	3	253	c.233G>A	c.(232-234)gGg>gAg	p.G78E		NM_001030013.1	NP_001025184.1	P0C0P6	NPS_HUMAN	neuropeptide S	78					neuropeptide signaling pathway	extracellular region				haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						GTTGGCACAGGGATGAAAAAA	0.413000													55	148					0	0	1	0	0
RAX	30062	broad.mit.edu	37	18	56939653	56939653	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56939653C>T	ENST00000334889.3	-	2	669	c.483G>A	c.(481-483)ccG>ccA	p.P161P	RAX_ENST00000256852.7_Intron	NM_013435.2	NP_038463.2	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	161					visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)		TGTACACGTCCGGGTAGTGGG	0.622000													34	51					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42225911	42225911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:42225911G>A	ENST00000541110.1	-	10	2926	c.2358C>T	c.(2356-2358)gtC>gtT	p.V786V	TRERF1_ENST00000340840.2_Silent_p.V683V|TRERF1_ENST00000354325.2_Silent_p.V683V|TRERF1_ENST00000372917.4_Silent_p.V683V|TRERF1_ENST00000372922.4_Silent_p.V766V			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	766	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCCCTGGGGTGACCGTCACGT	0.433000													15	35					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21239752	21239752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:21239752C>T	ENST00000261560.5	+	5	819	c.638C>T	c.(637-639)tCg>tTg	p.S213L		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						TGTGACAAATCGTTTTGCATG	0.284000													9	27					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95606832	95606832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:95606832G>A	ENST00000324972.6	+	7	743	c.550G>A	c.(550-552)Gaa>Aaa	p.E184K	DYNC1I1_ENST00000457059.1_Missense_Mutation_p.E167K|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.E147K|DYNC1I1_ENST00000447467.2_Missense_Mutation_p.E167K|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.E164K|DYNC1I1_ENST00000359388.4_Missense_Mutation_p.E147K	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	184					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			AGAGGATGAGGAAGATGAGGA	0.368000													19	25					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32090200	32090200	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:32090200C>G	ENST00000438447.1	+	20	7034	c.6646C>G	c.(6646-6648)Cca>Gca	p.P2216A	PDZD2_ENST00000282493.3_Missense_Mutation_p.P2216A			O15018	PDZD2_HUMAN	PDZ domain containing 2	2216					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CTACTTCACCCCAAGGCCAGC	0.617000													62	336					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941685	144941685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144941685G>A	ENST00000525985.1	-	2	5808	c.5737C>T	c.(5737-5739)Ctc>Ttc	p.L1913F				P58107	EPIPL_HUMAN	epiplakin 1	1913						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCTCATGGAGGCTCATGACC	0.662000													9	37					0	0	1	0	0
C3orf36	80111	broad.mit.edu	37	3	133647250	133647250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133647250G>A	ENST00000408895.2	-	1	1406	c.398C>T	c.(397-399)tCt>tTt	p.S133F		NM_025041.2	NP_079317.2	Q3SXR2	CC036_HUMAN	chromosome 3 open reading frame 36	133	Poly-Ser.									breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	6						GAAGGTGGAAGAGGAAGAGAG	0.592000													14	45					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186671899	186671899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:186671899G>A	ENST00000343098.5	+	17	18133	c.18133G>A	c.(18133-18135)Gaa>Aaa	p.E6045K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E5956K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AGTGATAAATGAAATTTTCCA	0.318000													46	123					0	0	1	0	0
PROP1	5626	broad.mit.edu	37	5	177421114	177421114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:177421114C>T	ENST00000308304.2	-	2	643	c.335G>A	c.(334-336)cGa>cAa	p.R112Q		NM_006261.4	NP_006252.3	O75360	PROP1_HUMAN	PROP paired-like homeobox 1	112					central nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(9)|stomach(1)	13	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACCTGGATTCGGGCCTCACT	0.527000													37	102					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899198	233899198	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233899198C>T	ENST00000233840.3	+	2	574	c.574C>T	c.(574-576)Ccc>Tcc	p.P192S		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	192							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		AAGGCCGATCCCCTCTGCCTT	0.657000													38	70					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72680646	72680646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72680646C>T	ENST00000261180.4	+	2	1061	c.965C>T	c.(964-966)tCa>tTa	p.S322L		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	322					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GATCACTTTTCACAGACCCCT	0.403000													41	117					0	0	1	0	0
CYTL1	54360	broad.mit.edu	37	4	5021056	5021056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:5021056G>A	ENST00000307746.4	-	1	143	c.117C>T	c.(115-117)acC>acT	p.T39T		NM_018659.2	NP_061129.1	Q9NRR1	CYTL1_HUMAN	cytokine-like 1	39					signal transduction	extracellular space|soluble fraction	receptor binding			breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		TGAAGTCGCGGGTGATCTCCT	0.692000													6	14					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361191	107361191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107361191G>A	ENST00000374779.2	-	1	597	c.504C>T	c.(502-504)ttC>ttT	p.F168F		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						TATTCCTGCAGAAAGGCAATT	0.448000													20	194					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43912144	43912144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:43912144G>A	ENST00000339069.5	+	13	1454	c.823G>A	c.(823-825)Gga>Aga	p.G275R	CRHR1_ENST00000398285.3_3'UTR|CRHR1_ENST00000314537.5_3'UTR			P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	0					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		GGCAGGTCATGGAGCAGCCCC	0.642000													12	22					0	0	1	0	0
OPALIN	93377	broad.mit.edu	37	10	98108055	98108055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98108055C>T	ENST00000419479.1	-	6	717	c.210G>A	c.(208-210)aaG>aaA	p.K70K	OPALIN_ENST00000536387.1_Silent_p.K70K|OPALIN_ENST00000371172.3_Silent_p.K80K|OPALIN_ENST00000393871.1_Silent_p.K57K|OPALIN_ENST00000393870.2_Silent_p.K69K	NM_001040103.1	NP_001035192.1	Q96PE5	OPALI_HUMAN	oligodendrocytic myelin paranodal and inner loop protein	80						Golgi apparatus|integral to membrane|plasma membrane				breast(1)|large_intestine(1)|lung(5)|prostate(2)	9						CCTCAGATATCTTGGGATTGT	0.333000													17	62					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111889718	111889718	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111889718G>A	ENST00000440460.2	+	21	2304	c.2007G>A	c.(2005-2007)ggG>ggA	p.G669G	DIXDC1_ENST00000389821.4_3'UTR|DIXDC1_ENST00000315253.5_Silent_p.G458G	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	670	DIX.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		GATGGGAAGGGAAAATTGTAG	0.428000													28	74					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72509681	72509681	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72509681G>A	ENST00000373208.1	+	16	2376	c.2376G>A	c.(2374-2376)gtG>gtA	p.V792V	ADAMTS14_ENST00000373207.1_Silent_p.V789V	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	789	Spacer.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						AGGATGCGGTGGAGGATGCCA	0.642000													12	57					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350414	51350414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51350414C>T	ENST00000327536.5	-	3	642	c.543G>A	c.(541-543)cgG>cgA	p.R181R	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	181										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		ACTGGTTGTTCCGGTAGAGGA	0.468000													46	105					0	0	1	0	0
ZNF823	55552	broad.mit.edu	37	19	11833307	11833307	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11833307G>A	ENST00000341191.6	-	4	1195	c.1042C>T	c.(1042-1044)Cga>Tga	p.R348*	ZNF823_ENST00000545749.1_Nonsense_Mutation_p.R166*	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R348*(2)		breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						TCATGATTTCGAACTGAACTA	0.418000										HNSCC(68;0.2)			20	155					0	0	1	0	0
IGHV3-23	28442	broad.mit.edu	37	14	106725366	106725366	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106725366C>T	ENST00000390609.2	-	0	264																											ACTCCAGCCCCTTCCCTGGAG	0.577000													51	490					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41621803	41621803	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41621803C>T	ENST00000216237.5	+	12	1520	c.1362C>T	c.(1360-1362)ctC>ctT	p.L454L		NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	454					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCCAGGTTCTCCTGGATGGAT	0.597000													17	44					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47162320	47162320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47162320G>A	ENST00000409792.3	-	3	3848	c.3806C>T	c.(3805-3807)aCc>aTc	p.T1269I		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1269				T -> A (in Ref. 4; CAC28349, 6; AAT77612 and 7; AAT77613).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTGATACGTGGTAGAAGGCTT	0.463000			"""N, F, S, Mis"""		clear cell renal carcinoma								37	87					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702494	30702494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30702494C>T	ENST00000256246.2	-	1	4114	c.4040G>A	c.(4039-4041)gGa>gAa	p.G1347E		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1347										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGAAGATTCTCCCTCACTATC	0.408000													15	129					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348928	89348928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89348928G>A	ENST00000301030.4	-	9	4482	c.4022C>T	c.(4021-4023)cCt>cTt	p.P1341L	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1341L	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1341	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CAGCTTCTCAGGGAGGCAGGC	0.592000													24	52					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17791332	17791332	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:17791332G>A	ENST00000380607.4	+	7	848	c.728_splice	c.e7+1	p.R243_splice	SH3GL2_ENST00000537391.1_Splice_Site_p.R196_splice	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	243	BAR.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		CTGGAAGAAAGGTATTCTACA	0.428000													5	71					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	78005818	78005818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:78005818C>T	ENST00000302536.2	+	8	1302	c.1149C>T	c.(1147-1149)acC>acT	p.T383T		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	383							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						TAGAAAAGACCCCAACTCCAC	0.532000											OREG0023950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	222					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79385646	79385646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79385646C>T	ENST00000264895.6	+	49	7378	c.6938C>T	c.(6937-6939)cCc>cTc	p.P2313L		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2312					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GATTCGCTGCCCGTCGTACAG	0.532000													12	79					0	0	1	0	0
NDUFC2	4718	broad.mit.edu	37	11	77784157	77784157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:77784157G>A	ENST00000281031.4	-	2	671	c.197C>T	c.(196-198)gCc>gTc	p.A66V	NDUFC2_ENST00000527806.1_Missense_Mutation_p.A66V|NDUFC2_ENST00000528164.1_Missense_Mutation_p.A66V|NDUFC2_ENST00000525085.1_Intron|NDUFC2-KCTD14_ENST00000528251.1_Intron|NDUFC2_ENST00000534029.1_Intron|NDUFC2-KCTD14_ENST00000530054.1_Missense_Mutation_p.A66V	NM_001204055.1|NM_004549.5	NP_001190984.1|NP_004540.1			NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa											large_intestine(1)|lung(2)|prostate(1)	4	all_cancers(14;2.23e-19)|all_epithelial(13;7.49e-22)|Breast(9;6.38e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;2.15e-25)			AAAAAAAAAGGCCGTAATATA	0.353000													31	101					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29998372	29998372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29998372C>T	ENST00000308893.4	+	16	3822	c.2779C>T	c.(2779-2781)Cct>Tct	p.P927S	TAOK2_ENST00000543033.1_Missense_Mutation_p.P814S|TAOK2_ENST00000416441.2_Missense_Mutation_p.P754S|TAOK2_ENST00000279394.3_Intron	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	927					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CCCCGACATCCCTCCTGAACC	0.647000													51	218					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49218978	49218978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49218978G>A	ENST00000327979.2	-	13	1689	c.1278C>T	c.(1276-1278)ggC>ggT	p.G426G	FAM65C_ENST00000045083.2_Silent_p.G426G|FAM65C_ENST00000535356.1_Silent_p.G430G			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	426										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGGGCAGGAAGCCCACATCTG	0.637000													25	66					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40357749	40357749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40357749G>A	ENST00000221347.6	-	34	15571	c.15564C>T	c.(15562-15564)tcC>tcT	p.S5188S		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5188	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGGTCAGCAGGGAGGAGTTTA	0.572000													16	28					0	0	1	0	0
FOXI2	399823	broad.mit.edu	37	10	129536850	129536850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129536850G>A	ENST00000388920.4	+	2	617	c.578G>A	c.(577-579)aGg>aAg	p.R193K		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	193					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				AACTTCCGAAGGAAGAGGAAG	0.622000													8	20					0	0	1	0	0
PRR16	51334	broad.mit.edu	37	5	120022371	120022371	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:120022371G>A	ENST00000379551.2	+	3	1170	c.813G>A	c.(811-813)acG>acA	p.T271T	PRR16_ENST00000407149.2_Silent_p.T294T|PRR16_ENST00000446965.1_Silent_p.T224T|PRR16_ENST00000505123.1_Silent_p.T224T	NM_016644.1	NP_057728.1	Q569H4	PRR16_HUMAN	proline rich 16	294	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CACAGAAGACGATCTTGAGGA	0.398000													19	40					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14355033	14355033	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:14355033T>C	ENST00000571589.1	+	17	3204	c.3032T>C	c.(3031-3033)cTg>cCg	p.L1011P	MKL2_ENST00000574045.1_Missense_Mutation_p.L961P|MKL2_ENST00000318282.5_Missense_Mutation_p.L961P|MKL2_ENST00000341243.5_Missense_Mutation_p.L1000P	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	1000					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCCTTCTCTCTGATCGAGGAC	0.488000													7	62					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113532957	113532957	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113532957C>T	ENST00000257600.3	+	7	2000	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	DTX1_ENST00000547974.1_3'UTR	NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	499					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						TGCCCGGCTTCCCTGATACCC	0.652000													21	82					0	0	1	0	0
NR2E1	7101	broad.mit.edu	37	6	108499402	108499402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:108499402C>T	ENST00000368986.4	+	5	1307	c.599C>T	c.(598-600)gCt>gTt	p.A200V	NR2E1_ENST00000368983.3_Missense_Mutation_p.A237V	NM_003269.3	NP_003260.1	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	200	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		ATCAAGTGGGCTAAGAGTGTG	0.527000													21	32					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43872643	43872643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:43872643G>A	ENST00000261488.6	-	12	1862	c.1285C>T	c.(1285-1287)Ctg>Ttg	p.L429L	ENOX1_ENST00000412891.1_Silent_p.L429L	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	429					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TCCTCTTTCAGAGCGTAGGCC	0.527000													32	75					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760619	19760619	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19760619G>A	ENST00000357324.6	-	18	2492	c.2466C>T	c.(2464-2466)acC>acT	p.T822T	ATP13A1_ENST00000291503.5_Silent_p.T704T	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	822					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GCTGGGGGTCGGTGGCCTGCA	0.687000													7	36					0	0	1	0	0
BSPRY	54836	broad.mit.edu	37	9	116132182	116132182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116132182C>T	ENST00000374183.4	+	6	1008	c.969C>T	c.(967-969)ttC>ttT	p.F323F	BSPRY_ENST00000462085.1_3'UTR	NM_017688.2	NP_060158.2	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	323	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						ACAATGCCTTCTCCTGGGTCT	0.607000													22	44					0	0	1	0	0
C7orf10	79783	broad.mit.edu	37	7	40277264	40277264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:40277264G>A	ENST00000309930.5	+	7	560	c.536G>A	c.(535-537)cGa>cAa	p.R179Q	C7orf10_ENST00000335693.4_Missense_Mutation_p.R179Q|C7orf10_ENST00000401647.2_Missense_Mutation_p.R179Q	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	179							transferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						ATTTCTCAGCGAGCTGGTTAT	0.433000													26	55					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71095058	71095058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71095058C>T	ENST00000283228.2	-	7	1505	c.1053G>A	c.(1051-1053)ggG>ggA	p.G351G	PTPRR_ENST00000549308.1_Silent_p.G106G|PTPRR_ENST00000440835.2_Silent_p.G106G|PTPRR_ENST00000342084.4_Silent_p.G239G|PTPRR_ENST00000378778.1_Silent_p.G145G	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	351					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GTTCAATGTTCCCCAAGCTAC	0.438000													20	80					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104955	183104955	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:183104955G>T	ENST00000435564.1	-	3	480	c.280C>A	c.(280-282)Cgg>Agg	p.R94R	PDE1A_ENST00000536095.1_5'UTR|PDE1A_ENST00000409365.1_Silent_p.R78R|PDE1A_ENST00000456212.1_Silent_p.R94R|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Silent_p.R94R|PDE1A_ENST00000358139.2_Silent_p.R94R|PDE1A_ENST00000351439.5_Silent_p.R78R|PDE1A_ENST00000331935.6_Silent_p.R94R|PDE1A_ENST00000346717.4_Silent_p.R60R	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	94					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.R94W(4)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			AACCAGTCCCGGACTTCAGAT	0.393000													30	68					8.88839e-20	8.94171e-20	1	1	0
MCUR1	63933	broad.mit.edu	37	6	13807255	13807255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13807255G>A	ENST00000379170.4	-	2	575	c.437C>T	c.(436-438)tCc>tTc	p.S146F	MCUR1_ENST00000359495.2_Missense_Mutation_p.S146F	NM_001031713.3	NP_001026883.1			mitochondrial calcium uniporter regulator 1																		CAGCTGCAGGGATCCAGCAGA	0.473000													40	65					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36524562	36524562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36524562C>T	ENST00000273183.3	+	3	767	c.467C>T	c.(466-468)cCc>cTc	p.P156L	STAC_ENST00000457375.2_Intron|STAC_ENST00000476388.1_3'UTR	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	156					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						GGCCTGGCACCCCAGCGGTGC	0.572000													9	57					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23250889	23250889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:23250889C>T	ENST00000298032.5	+	7	698	c.614C>T	c.(613-615)cCa>cTa	p.P205L	ARMC3_ENST00000409049.3_Missense_Mutation_p.P205L|ARMC3_ENST00000376528.4_Intron|ARMC3_ENST00000409983.3_Missense_Mutation_p.P205L	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	205							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TCAGAATATCCAGTGATTCAG	0.373000													15	38					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20893163	20893163	+	Missense_Mutation	SNP	G	G	A	rs149798560		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:20893163G>A	ENST00000381552.1	+	12	1962	c.1594G>A	c.(1594-1596)Gga>Aga	p.G532R	SLCO1C1_ENST00000540354.1_Missense_Mutation_p.G483R|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.G532R|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.G414R|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.G532R			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	532					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TTCTAAATCCGGAAATTCCTC	0.353000													27	98					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33154504	33154504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33154504C>T	ENST00000341947.2	-	5	925	c.698G>A	c.(697-699)aGg>aAg	p.R233K	COL11A2_ENST00000374714.1_Missense_Mutation_p.R233K|COL11A2_ENST00000361917.1_Missense_Mutation_p.R233K|COL11A2_ENST00000395194.1_Missense_Mutation_p.R233K|COL11A2_ENST00000395197.1_Missense_Mutation_p.R233K|COL11A2_ENST00000374713.1_Missense_Mutation_p.R233K|COL11A2_ENST00000374712.1_Missense_Mutation_p.R233K|COL11A2_ENST00000374708.4_Missense_Mutation_p.R233K|COL11A2_ENST00000357486.1_Missense_Mutation_p.R233K	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	233	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GGGTCTTTCCCTCTGGCCCCC	0.562000													48	102					0	0	1	0	0
PHF7	51533	broad.mit.edu	37	3	52457136	52457136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52457136C>T	ENST00000327906.3	+	11	1609	c.949C>T	c.(949-951)Cct>Tct	p.P317S	PHF7_ENST00000478707.1_Missense_Mutation_p.P317S|PHF7_ENST00000347025.2_Missense_Mutation_p.P278S	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	317						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		AGGGGACATCCCTTGCTGCAG	0.527000													38	87					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21747441	21747441	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21747441G>A	ENST00000328843.6	+	41	6723	c.6692G>A	c.(6691-6693)tGg>tAg	p.W2231*	DNAH11_ENST00000409508.3_Nonsense_Mutation_p.W2224*			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2231	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ACCCGAGAATGGAAAGATGGC	0.378000									Kartagener syndrome				4	44					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90904247	90904247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90904247G>A	ENST00000354377.3	+	4	1370	c.1184G>A	c.(1183-1185)cGa>cAa	p.R395Q	ZNF774_ENST00000379090.5_Intron	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AAGCACCAACGAATCCACACC	0.498000													16	68					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66426077	66426077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66426077C>T	ENST00000341529.3	+	7	1156	c.1008C>T	c.(1006-1008)atC>atT	p.I336I	CDH5_ENST00000563425.2_Silent_p.I336I	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	336	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		ACAGCTTCATCGTCGAGGCCA	0.542000													52	186					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20491956	20491956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20491956G>A	ENST00000573854.1	+	11	1457	c.1343G>A	c.(1342-1344)gGa>gAa	p.G448E	ACSM2A_ENST00000417235.2_Missense_Mutation_p.G369E|ACSM2A_ENST00000536134.1_Missense_Mutation_p.G220E|ACSM2A_ENST00000396104.2_Missense_Mutation_p.G448E|ACSM2A_ENST00000219054.6_Missense_Mutation_p.G448E|ACSM2A_ENST00000575690.1_Missense_Mutation_p.G448E|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	448					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GGAGACCGGGGAATCAAAGAT	0.488000													10	88					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26676280	26676280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26676280G>A	ENST00000288710.2	+	14	1856	c.1782G>A	c.(1780-1782)atG>atA	p.M594I		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		agacggagatggagggagaaa	0.572000													28	69					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73513451	73513451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:73513451C>T	ENST00000418310.1	+	5	683	c.581C>T	c.(580-582)aCc>aTc	p.T194I	LIMK1_ENST00000491052.1_3'UTR|LIMK1_ENST00000336180.2_Missense_Mutation_p.T164I|LIMK1_ENST00000538333.3_Missense_Mutation_p.T130I			P53667	LIMK1_HUMAN	LIM domain kinase 1	164	PDZ.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				CACACCGTCACCCTGGTGTCC	0.647000													53	124					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179643770	179643770	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179643770C>T	ENST00000589042.1	-	24	4263	c.4039G>A	c.(4039-4041)Gct>Act	p.A1347T	RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.A1347T|TTN_ENST00000360870.5_Missense_Mutation_p.A1347T|TTN_ENST00000591111.1_Missense_Mutation_p.A1347T|TTN_ENST00000342175.6_Missense_Mutation_p.A1301T|TTN_ENST00000359218.5_Missense_Mutation_p.A1301T|TTN_ENST00000460472.2_Missense_Mutation_p.A1301T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1347	Ig-like 5.		A -> T (in a metastatic melanoma sample; somatic mutation).				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.A1301T(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCAGACTAGCTCTGCCATCT	0.403000													14	57					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170805228	170805228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170805228G>A	ENST00000436636.2	-	24	3133	c.2789C>T	c.(2788-2790)cCt>cTt	p.P930L	TNIK_ENST00000470834.1_Missense_Mutation_p.P893L|TNIK_ENST00000369326.5_Missense_Mutation_p.P908L|TNIK_ENST00000475336.1_Missense_Mutation_p.P838L|TNIK_ENST00000538048.1_Missense_Mutation_p.P882L|TNIK_ENST00000357327.5_Missense_Mutation_p.P901L|TNIK_ENST00000488470.1_Missense_Mutation_p.P875L|TNIK_ENST00000284483.8_Missense_Mutation_p.P922L|TNIK_ENST00000460047.1_Missense_Mutation_p.P867L|TNIK_ENST00000341852.6_Missense_Mutation_p.P846L	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	930	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CACCAGGTCAGGGAGGTTGAT	0.587000													28	82					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962660	41962660	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:41962660C>T	ENST00000454645.1	-	0	844					NR_003670.1																						ATTTCCCCTCCGTTGTTTGTC	0.363000													5	47					0	0	1	0	0
CNTFR	1271	broad.mit.edu	37	9	34564810	34564810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34564810C>T	ENST00000378980.3	-	4	399	c.106G>A	c.(106-108)Gag>Aag	p.E36K	CNTFR_ENST00000351266.4_Missense_Mutation_p.E36K	NM_001207011.1|NM_147164.2	NP_001193940.1|NP_671693.1	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	36	Ig-like C2-type.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(4)|skin(1)	15	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		CCCAGGCGCTCGTACTGCACA	0.652000													15	37					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75444658	75444658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:75444658C>T	ENST00000549446.1	-	3	1807	c.1127G>A	c.(1126-1128)cGa>cAa	p.R376Q	KCNC2_ENST00000341669.3_Missense_Mutation_p.R376Q|KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000548513.1_Missense_Mutation_p.R376Q|KCNC2_ENST00000550433.1_Missense_Mutation_p.R376Q|KCNC2_ENST00000393288.2_Missense_Mutation_p.R376Q|KCNC2_ENST00000350228.2_Missense_Mutation_p.R376Q|KCNC2_ENST00000540018.1_Missense_Mutation_p.R376Q|KCNC2_ENST00000298972.1_Missense_Mutation_p.R376Q	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	376					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						AGTACTAGCTCGAAGAGTATG	0.453000													6	48					0	0	1	0	0
SVOPL	136306	broad.mit.edu	37	7	138314867	138314867	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138314867C>T	ENST00000421622.1	-	6	638	c.429_splice	c.e6-1	p.E144_splice	SVOPL_ENST00000436657.1_Splice_Site_p.E112_splice|SVOPL_ENST00000288513.5_Splice_Site_p.E112_splice|SVOPL_ENST00000419765.3_Splice_Site_p.E264_splice			Q8N434	SVOPL_HUMAN	SVOP-like	264						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						CCTCTTTTTTCCTGGGGTAAT	0.388000													11	55					0	0	1	0	0
BCL6B	255877	broad.mit.edu	37	17	6930397	6930397	+	Silent	SNP	G	G	A	rs117980493	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6930397G>A	ENST00000293805.5	+	8	1406	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K		NM_181844.3	NP_862827.1	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B	438						nucleus	zinc ion binding			skin(1)	1						CCGGAGAGAAGCCTTACCACG	0.632000													15	43					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25266961	25266961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:25266961C>T	ENST00000218548.6	+	10	1655	c.1322C>T	c.(1321-1323)tCc>tTc	p.S441F	ATP12A_ENST00000381946.3_Missense_Mutation_p.S435F	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	435					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ACTTGGGCCTCCTTATCCAAG	0.493000													63	267					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7629892	7629892	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:7629892C>T	ENST00000340209.4	+	3	696	c.399C>T	c.(397-399)ttC>ttT	p.F133F	RBFOX1_ENST00000422070.4_Silent_p.F171F|RBFOX1_ENST00000547338.1_Silent_p.F128F|RBFOX1_ENST00000547372.1_Silent_p.F171F|RBFOX1_ENST00000355637.4_Silent_p.F148F|RBFOX1_ENST00000553186.1_Silent_p.F128F|RBFOX1_ENST00000436368.2_Silent_p.F148F|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000311745.5_Silent_p.F148F|RBFOX1_ENST00000552089.1_Silent_p.F163F|RBFOX1_ENST00000550418.1_Silent_p.F128F			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	128	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						CCTTCAGGTTCCGGGATCCGG	0.547000													22	51					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44489665	44489665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:44489665G>A	ENST00000425708.2	-	7	1839	c.1498C>T	c.(1498-1500)Ctt>Ttt	p.L500F	ZNF445_ENST00000396077.2_Missense_Mutation_p.L500F			P59923	ZN445_HUMAN	zinc finger protein 445	500					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TGATACGCAAGATGGGAGCTA	0.493000													42	72					0	0	1	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148968136	148968136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:148968136C>T	ENST00000336498.3	+	20	2200	c.1961C>T	c.(1960-1962)cCt>cTt	p.P654L	ARHGAP10_ENST00000414545.2_Missense_Mutation_p.P303L	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	654					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		GTCCCTGGGCCTCCTGGACCA	0.562000													25	61					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131864564	131864564	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131864564G>A	ENST00000359827.3	-	20	4718	c.3756C>T	c.(3754-3756)ttC>ttT	p.F1252F	PLXNA4_ENST00000321063.4_Silent_p.F1252F			Q9HCM2	PLXA4_HUMAN	plexin A4	1252						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CGGCCACGATGAAAATGATGA	0.612000													6	23					0	0	1	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3391322	3391322	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3391322C>T	ENST00000378378.4	+	9	1761	c.1356C>T	c.(1354-1356)agC>agT	p.S452S	ARHGEF16_ENST00000378373.1_Silent_p.S164S|ARHGEF16_ENST00000378371.2_Silent_p.S164S|ARHGEF16_ENST00000413250.2_Silent_p.S156S	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	452	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		AGGCTGCCAGCCGTGCACTGA	0.632000													14	78					0	0	1	0	0
PRRX1	5396	broad.mit.edu	37	1	170688895	170688895	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:170688895G>A	ENST00000239461.6	+	2	583	c.270G>A	c.(268-270)aaG>aaA	p.K90K	PRRX1_ENST00000497230.2_Silent_p.K90K|PRRX1_ENST00000367760.3_Silent_p.K90K	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	90						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AAGAAAAAAAGAAGAGAAAGC	0.433000													6	27					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106121808	106121808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106121808G>A	ENST00000369704.3	+	3	453	c.319G>A	c.(319-321)Gac>Aac	p.D107N	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	107										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GAAGATGGTGGACTCAGCCTA	0.458000													17	49					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2931166	2931166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:2931166C>T	ENST00000381130.2	+	3	293	c.293C>T	c.(292-294)aCt>aTt	p.T98I		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	98						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AATGAAACGACTTTTGCCAAG	0.552000													46	28					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117791663	117791663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117791663C>T	ENST00000350763.4	-	25	6556	c.6145G>A	c.(6145-6147)Gac>Aac	p.D2049N	TNC_ENST00000535648.1_Missense_Mutation_p.D1594N|TNC_ENST00000542877.1_Missense_Mutation_p.D1686N|TNC_ENST00000423613.2_Missense_Mutation_p.D1776N|TNC_ENST00000346706.3_Missense_Mutation_p.D1503N|TNC_ENST00000537320.1_Missense_Mutation_p.D1412N|TNC_ENST00000341037.4_Missense_Mutation_p.D1867N|TNC_ENST00000345230.3_Missense_Mutation_p.D1412N|TNC_ENST00000340094.3_Missense_Mutation_p.D1685N	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2049	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TCTCTGCGGTCCCCAAATCCA	0.468000													25	88					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39799066	39799066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39799066C>T	ENST00000248668.4	-	2	1522	c.1523G>A	c.(1522-1524)cGa>cAa	p.R508Q		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	508	Fibronectin type-III.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GCCCACCACTCGCGTTGCCGG	0.677000													7	19					0	0	1	0	0
GBA	2629	broad.mit.edu	37	1	155207230	155207230	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155207230G>A	ENST00000428024.2	-	6	1142	c.640C>T	c.(640-642)Cgt>Tgt	p.R214C	GBA_ENST00000368373.3_Missense_Mutation_p.R301C|GBA_ENST00000536770.1_Missense_Mutation_p.R188C|GBA_ENST00000327247.5_Missense_Mutation_p.R301C|GBA_ENST00000427500.2_Missense_Mutation_p.R252C	NM_001171811.1	NP_001165282.1	P04062	GLCM_HUMAN	glucosidase, beta, acid	301					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	26	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	CCTAGGTCACGGGCAATGAAG	0.572000									Gaucher disease type I				12	64					0	0	1	0	0
ELOVL4	6785	broad.mit.edu	37	6	80634670	80634670	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:80634670C>T	ENST00000369816.4	-	3	668	c.369_splice	c.e3+1	p.R123_splice		NM_022726.3	NP_073563.1	Q9GZR5	ELOV4_HUMAN	ELOVL fatty acid elongase 4	123					fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	TGTACTTACCCTGACTTCATG	0.303000													18	34					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8176468	8176468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:8176468G>A	ENST00000520004.1	-	6	3681	c.3417C>T	c.(3415-3417)atC>atT	p.I1139I	SGK223_ENST00000330777.4_Silent_p.I1139I			Q86YV5	SG223_HUMAN		1139	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity										CCCGGTGGATGATCCCGTGCT	0.741000													14	160					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814675	106814675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106814675G>A	ENST00000407775.2	+	8	2615	c.2365G>A	c.(2365-2367)Gat>Aat	p.D789N	ZFPM2_ENST00000520492.1_Missense_Mutation_p.D657N|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.D520N|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.D657N|RP11-152P17.2_ENST00000518932.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	789					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CCCAAGATGTGATATCTTTCC	0.438000													12	26					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60557969	60557969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60557969G>A	ENST00000308287.1	+	2	257	c.161G>A	c.(160-162)aGc>aAc	p.S54N		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	54						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						CAGAAGAAGAGCAGCCTTCTT	0.632000													23	63					0	0	1	0	0
MPP4	58538	broad.mit.edu	37	2	202552063	202552063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202552063G>A	ENST00000409474.3	-	5	518	c.311C>T	c.(310-312)tCc>tTc	p.S104F	MPP4_ENST00000428900.2_Missense_Mutation_p.S104F|MPP4_ENST00000409143.1_Intron|MPP4_ENST00000396886.3_Missense_Mutation_p.S104F|MPP4_ENST00000447335.2_Missense_Mutation_p.S104F|MPP4_ENST00000315506.7_Missense_Mutation_p.S104F|MPP4_ENST00000359962.5_Missense_Mutation_p.S104F	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	104	L27 2.					cytoplasm	protein binding			kidney(1)|lung(11)	12						GATCTCAGGGGAAGTAGGGGT	0.413000													3	9					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43766210	43766210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43766210G>A	ENST00000244293.7	-	3	577	c.511C>T	c.(511-513)Cct>Tct	p.P171S	PSG9_ENST00000593948.1_Missense_Mutation_p.P171S|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000443718.3_Intron|PSG9_ENST00000291752.5_Intron|PSG9_ENST00000270077.3_Missense_Mutation_p.P171S			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	171	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGAGTCTCAGGATCACAGATT	0.532000													111	275					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463882	25463882	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25463882C>T	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						ATGCTGGGATCCCAGGGTCCC	0.522000													76	178					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44371558	44371558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44371558C>T	ENST00000371477.3	+	6	851	c.552C>T	c.(550-552)gcC>gcT	p.A184A		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	184					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTCTTGCTGCCCTCCAAAAAA	0.348000													22	59					0	0	1	0	0
MLYCD	23417	broad.mit.edu	37	16	83948952	83948952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:83948952C>T	ENST00000262430.4	+	5	1359	c.1340C>T	c.(1339-1341)tCc>tTc	p.S447F	RP11-505K9.4_ENST00000561562.1_RNA	NM_012213.2	NP_036345.2	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase	447					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						ATCACCGGCTCCTGCGGCCTG	0.627000													26	61					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153077667	153077667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153077667G>A	ENST00000285900.5	+	9	1541	c.1198G>A	c.(1198-1200)Gat>Aat	p.D400N	GRIA1_ENST00000518142.1_Missense_Mutation_p.D320N|GRIA1_ENST00000518783.1_Missense_Mutation_p.D410N|GRIA1_ENST00000521843.2_Missense_Mutation_p.D331N|GRIA1_ENST00000448073.4_Missense_Mutation_p.D410N|GRIA1_ENST00000340592.5_Missense_Mutation_p.D400N	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	400					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGCTGGGGGCGATAATTCAAG	0.478000													16	46					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183675836	183675836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183675836C>T	ENST00000511685.1	+	22	4439	c.4316C>T	c.(4315-4317)tCc>tTc	p.S1439F	TENM3_ENST00000406950.2_Missense_Mutation_p.S1439F|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3									p.S1439F(1)									GGAGAAATCTCCTTAGTGGCC	0.468000													16	39					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94224659	94224659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94224659G>A	ENST00000515393.1	-	12	1857	c.1858C>T	c.(1858-1860)Cac>Tac	p.H620Y	MCTP1_ENST00000505208.1_Missense_Mutation_p.H399Y|MCTP1_ENST00000429576.2_Missense_Mutation_p.H353Y|MCTP1_ENST00000505078.1_Missense_Mutation_p.H136Y|MCTP1_ENST00000312216.8_Missense_Mutation_p.H399Y	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	620	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTCAGGTTGTGAAATATCCTC	0.433000													37	75					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108313328	108313328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:108313328C>T	ENST00000370056.4	-	6	852	c.578G>A	c.(577-579)cGa>cAa	p.R193Q	VAV3_ENST00000527011.1_Missense_Mutation_p.R193Q|VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000371846.4_Missense_Mutation_p.R128Q	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	193	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity	p.R193Q(2)		NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		ACAACAACTTCGTATATCATT	0.299000													30	132					0	0	1	0	0
IFNLR1	163702	broad.mit.edu	37	1	24483700	24483700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24483700C>T	ENST00000327535.1	-	7	1495	c.1483G>A	c.(1483-1485)Gat>Aat	p.D495N	IFNLR1_ENST00000374421.3_Missense_Mutation_p.D466N|IFNLR1_ENST00000327575.2_3'UTR	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1																		CTGCCCGCATCGCTGTCCTCA	0.627000													11	57					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300147	18300147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:18300147G>A	ENST00000441493.2	-	26	5632	c.5280C>T	c.(5278-5280)tgC>tgT	p.C1760C		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1760						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GGGTGCTGGGGCAGGACTTGT	0.637000													15	17					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52604148	52604148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52604148C>T	ENST00000521776.2	+	2	1941	c.1208C>T	c.(1207-1209)tCt>tTt	p.S403F		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	403					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		CATGAGGTTTCTGCAAGTGAG	0.498000													25	75					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18736157	18736157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18736157C>T	ENST00000513874.1	-	12	1685	c.1546G>A	c.(1546-1548)Gtg>Atg	p.V516M	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	516										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						CCGCTCTTCACTGTGGCCAGA	0.607000													21	53					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88958337	88958337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:88958337C>T	ENST00000268679.4	-	5	1060	c.664G>A	c.(664-666)Gag>Aag	p.E222K	CBFA2T3_ENST00000360302.2_Missense_Mutation_p.E136K|CBFA2T3_ENST00000448839.1_Missense_Mutation_p.E146K|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.E136K|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.E197K	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	222	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).|TAFH.				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		TTGGTGGCCTCCTGAAGCTTG	0.587000			T	RUNX1	AML								10	30					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47500966	47500966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47500966C>T	ENST00000285039.7	-	10	1375	c.1076G>A	c.(1075-1077)aGc>aAc	p.S359N		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	359	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GCAGAAGTTGCTTAGGTATAC	0.592000													41	95					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25735272	25735272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:25735272G>A	ENST00000349320.3	-	4	577	c.189C>T	c.(187-189)ttC>ttT	p.F63F	RHCE_ENST00000455194.1_Silent_p.F79F|RHCE_ENST00000425135.1_Silent_p.F79F|RHCE_ENST00000374352.2_Silent_p.F63F|RHCE_ENST00000413854.1_Silent_p.F79F|RHCE_ENST00000346452.4_Silent_p.F79F|RHCE_ENST00000349438.4_Silent_p.F79F|RHCE_ENST00000340849.4_Silent_p.F79F|RHCE_ENST00000243186.6_Silent_p.F79F|RHCE_ENST00000495048.1_5'UTR|RHCE_ENST00000294413.7_Silent_p.F79F			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	79						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		TGAAGAGGTTGAAGGCCACAC	0.597000													18	48					0	0	1	0	0
GFOD1	54438	broad.mit.edu	37	6	13365806	13365806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13365806G>A	ENST00000379287.3	-	2	1006	c.342C>T	c.(340-342)ctC>ctT	p.L114L	GFOD1_ENST00000379284.1_Silent_p.L11L	NM_018988.3	NP_061861.1	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain containing 1	114						extracellular region	binding|oxidoreductase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)	18	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			TGATGCTCATGAGCTTGGGGT	0.652000													49	114					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73442842	73442842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:73442842C>T	ENST00000377110.2	-	6	1137	c.894G>A	c.(892-894)ggG>ggA	p.G298G	TRPM3_ENST00000396292.4_Silent_p.G145G|TRPM3_ENST00000360823.2_Silent_p.G145G|TRPM3_ENST00000423814.3_Silent_p.G300G|TRPM3_ENST00000396285.1_Silent_p.G145G|TRPM3_ENST00000358082.3_Silent_p.G145G|TRPM3_ENST00000396283.1_Silent_p.G145G|TRPM3_ENST00000377101.1_Silent_p.G145G|TRPM3_ENST00000357533.2_Silent_p.G300G|TRPM3_ENST00000377105.1_Silent_p.G145G|TRPM3_ENST00000377106.1_Silent_p.G145G|TRPM3_ENST00000361823.5_Silent_p.G145G|TRPM3_ENST00000396280.5_Silent_p.G145G|TRPM3_ENST00000377111.2_Silent_p.G298G|TRPM3_ENST00000408909.2_Silent_p.G145G	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	298						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TTCCAGTGGTCCCGTTGTCAG	0.483000													52	116					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61264576	61264576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61264576C>T	ENST00000344731.5	+	8	1257	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	SERPINB13_ENST00000269489.5_Silent_p.F333F	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	385					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						TCCTCTTCTTCGGCAGATTTT	0.423000													47	97					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294158	25294158	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25294158G>A	ENST00000400358.4	+	19	2299	c.2242G>A	c.(2242-2244)Gtg>Atg	p.V748M	SGSM1_ENST00000400359.4_Missense_Mutation_p.V803M	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	803	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						CACCCCCACGGTGCTGCGACC	0.632000													13	64					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27687295	27687295	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27687295G>A	ENST00000438700.3	-	4	2349	c.2232C>T	c.(2230-2232)atC>atT	p.I744I		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	744					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GGGAAGAAATGATTTCATTTG	0.308000													16	42					0	0	1	0	0
GPX3	2878	broad.mit.edu	37	5	150407677	150407677	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150407677G>A	ENST00000388825.4	+	5	759	c.667G>A	c.(667-669)Gtc>Atc	p.V223I	GPX3_ENST00000517973.1_3'UTR	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	223					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	AGCCCTGGGGGTCAAGAGGAA	0.562000													3	4					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122002628	122002628	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122002628G>A	ENST00000498619.1	+	7	2295	c.1857G>A	c.(1855-1857)acG>acA	p.T619T	CASR_ENST00000296154.5_Silent_p.T609T|CASR_ENST00000490131.1_Silent_p.T609T	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	609					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGTCGTGGACGGAGCCCTTTG	0.527000													14	56					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149263075	149263075	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149263075G>A	ENST00000255266.5	-	17	2171	c.2052C>T	c.(2050-2052)atC>atT	p.I684I		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	684					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ACTGATCCACGATCTTTTGGA	0.448000													17	41					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131849943	131849943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131849943C>T	ENST00000359827.3	-	23	5265	c.4303G>A	c.(4303-4305)Gag>Aag	p.E1435K	PLXNA4_ENST00000321063.4_Missense_Mutation_p.E1435K			Q9HCM2	PLXA4_HUMAN	plexin A4	1435						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						AGCATCTTCTCAGCCACTGAC	0.527000													30	56					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181721295	181721295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181721295G>A	ENST00000526775.1	+	26	3856	c.3691G>A	c.(3691-3693)Gac>Aac	p.D1231N	CACNA1E_ENST00000367570.1_Missense_Mutation_p.D1250N|CACNA1E_ENST00000367567.4_Missense_Mutation_p.D857N|CACNA1E_ENST00000360108.3_Missense_Mutation_p.D1231N|CACNA1E_ENST00000357570.5_Missense_Mutation_p.D1201N|CACNA1E_ENST00000358338.5_Missense_Mutation_p.D1182N|CACNA1E_ENST00000367573.2_Missense_Mutation_p.D1250N	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1250	Poly-Val.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CAAAGGACGGGACATCAAGAC	0.478000													26	73					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6553068	6553068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6553068G>A	ENST00000263125.5	-	3	306	c.207C>T	c.(205-207)gtC>gtT	p.V69V	PRKCQ_ENST00000539722.1_5'UTR|PRKCQ_ENST00000397176.2_Silent_p.V69V	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	69	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TGATCTGCATGACTCTTCCCT	0.493000													52	110					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50611658	50611658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50611658G>A	ENST00000444124.2	-	2	326	c.126C>T	c.(124-126)atC>atT	p.I42I	DDC_ENST00000431062.1_Silent_p.I42I|DDC_ENST00000380984.4_Silent_p.I42I|DDC_ENST00000357936.5_Silent_p.I42I|DDC_ENST00000426377.1_Silent_p.I42I	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	42					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CAGCGGCAGGGATCAGCGGCC	0.562000													92	118					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9449315	9449315	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9449315G>A	ENST00000378501.2	+	32	3325	c.3310G>A	c.(3310-3312)Gaa>Aaa	p.E1104K	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.E1116K|PLCB4_ENST00000278655.4_Missense_Mutation_p.E1104K|PLCB4_ENST00000378493.1_Missense_Mutation_p.E1104K|PLCB4_ENST00000334005.3_Missense_Mutation_p.E1104K|PLCB4_ENST00000378473.3_Missense_Mutation_p.E1116K	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	1104					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AGCAGAACGGGAAAGGTAAGT	0.418000													32	68					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380486	56380486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56380486G>A	ENST00000526538.1	-	1	492	c.493C>T	c.(493-495)Cac>Tac	p.H165Y		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						AAGGATAAGTGAAAGGTTAGC	0.463000													15	48					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400656	89400656	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89400656C>T	ENST00000439576.2	+	12	5214	c.4840C>T	c.(4840-4842)Cta>Tta	p.L1614L	ACAN_ENST00000352105.7_Silent_p.L1614L|ACAN_ENST00000559004.1_Silent_p.L1614L|ACAN_ENST00000561243.1_Silent_p.L1614L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1614					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TTCTGGAACTCTAGGAAGTGG	0.547000													45	177					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86919144	86919144	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86919144T>C	ENST00000370565.4	+	13	2410	c.2248T>C	c.(2248-2250)Ttt>Ctt	p.F750L	CLCA2_ENST00000498802.1_3'UTR	NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	750					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AGGAGGCTCCTTTTCAGTGCT	0.488000													7	110					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126882788	126882788	+	Silent	SNP	G	G	A	rs146190169	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:126882788G>A	ENST00000339582.2	-	2	1279	c.471C>T	c.(469-471)tcC>tcT	p.S157S	GRM8_ENST00000405249.1_Silent_p.S157S|GRM8_ENST00000444921.2_Silent_p.S157S|GRM8_ENST00000358373.3_Silent_p.S157S			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	157					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGATGGACACGGAGCTTGCTG	0.428000										HNSCC(24;0.065)			13	113					0	0	1	0	0
PRKCE	5581	broad.mit.edu	37	2	46237647	46237647	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:46237647C>T	ENST00000306156.3	+	10	1755	c.1428C>T	c.(1426-1428)ttC>ttT	p.F476F	PRKCE_ENST00000394874.1_Silent_p.F199F	NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	476	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity	p.F476L(1)	MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			ACTGCTGCTTCCAGACCAAGG	0.473000													10	67					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166891946	166891946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:166891946C>T	ENST00000271417.3	-	8	1150	c.1095G>A	c.(1093-1095)ggG>ggA	p.G365G	ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000525740.1_Silent_p.G238G|ILDR2_ENST00000526687.1_Silent_p.G257G|ILDR2_ENST00000469934.2_Silent_p.G365G|ILDR2_ENST00000529071.1_Silent_p.G346G|ILDR2_ENST00000528703.1_Silent_p.G306G	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	365						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						TCTCCAAGTCCCCAGACACAG	0.532000													36	198					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833477	61833477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61833477C>T	ENST00000280772.1	-	37	7353	c.7162G>A	c.(7162-7164)Gaa>Aaa	p.E2388K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2388					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGACCCTGTTCCTCTGAACAA	0.398000													79	32					0	0	1	0	0
ICAM1	3383	broad.mit.edu	37	19	10395216	10395216	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10395216C>T	ENST00000264832.3	+	5	1388	c.1063C>T	c.(1063-1065)Cag>Tag	p.Q355*	CTD-2369P2.5_ENST00000592893.1_RNA|ICAM1_ENST00000423829.2_Nonsense_Mutation_p.Q133*	NM_000201.2	NP_000192.2	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1	355	Ig-like C2-type 4.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	CCCGAGGGCCCAGCTCCTGCT	0.642000													12	95					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124371784	124371784	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124371784G>A	ENST00000409039.3	+	51	8590	c.8565G>A	c.(8563-8565)gcG>gcA	p.A2855A		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2855	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGAACAAAGCGATGATCTTTC	0.542000													15	26					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303925	151303925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151303925G>A	ENST00000370323.4	-	4	484	c.168C>T	c.(166-168)tcC>tcT	p.S56S	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Silent_p.S56S	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	56	Poly-Ser.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					aggaggaagaggaggaggagg	0.557000													19	40					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26158069	26158069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:26158069C>T	ENST00000325250.1	+	2	1154	c.967C>T	c.(967-969)Cat>Tat	p.H323Y		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	323							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						AGCCAGGGCTCATACTGCTGC	0.502000													7	9					0	0	1	0	0
ADAD2	161931	broad.mit.edu	37	16	84224922	84224922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84224922C>T	ENST00000268624.3	+	1	179	c.86C>T	c.(85-87)cCc>cTc	p.P29L	ADAD2_ENST00000315906.5_Missense_Mutation_p.P29L|ADAD2_ENST00000567413.1_3'UTR	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	29					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						AGCCCCCAGCCCCGCCCCTGG	0.736000													7	9					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37325463	37325463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37325463G>A	ENST00000262825.5	+	5	628	c.411G>A	c.(409-411)agG>agA	p.R137R	CSF2RB_ENST00000406230.1_Silent_p.R137R|CSF2RB_ENST00000403662.3_Silent_p.R137R|CSF2RB_ENST00000536485.1_Silent_p.R78R	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	137	Fibronectin type-III 1.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CTGAGCCCAGGGACCTGCAGA	0.642000													52	143					0	0	1	0	0
RFX1	5989	broad.mit.edu	37	19	14094343	14094343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14094343G>A	ENST00000254325.4	-	3	618	c.384C>T	c.(382-384)acC>acT	p.T128T		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	128					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			TAGGAACGCCGGTCTGGCTGG	0.701000													5	14					0	0	1	0	0
OR13J1	392309	broad.mit.edu	37	9	35869520	35869520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35869520C>T	ENST00000377981.2	-	1	941	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			CCTCCTTGTTCCTCAGGCTGT	0.592000													13	42					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585473	82585473	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82585473C>T	ENST00000423517.2	-	5	5133	c.4796G>A	c.(4795-4797)gGa>gAa	p.G1599E	PCLO_ENST00000333891.8_Missense_Mutation_p.G1599E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1530					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTGCCTTTTCCCTTTGTTTC	0.428000													51	172					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886856	23886856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23886856G>A	ENST00000355349.3	-	31	4371	c.4209C>T	c.(4207-4209)gcC>gcT	p.A1403A		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1403					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CAGCCTCCACGGCCTCCTCAG	0.612000													33	53					0	0	1	0	0
TBCA	6902	broad.mit.edu	37	5	76989169	76989169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76989169G>A	ENST00000520039.1	-	2	78	c.62C>T	c.(61-63)tCc>tTc	p.S21F	TBCA_ENST00000520361.1_Intron|TBCA_ENST00000380377.4_Silent_p.I56I|TBCA_ENST00000517881.1_5'UTR|TBCA_ENST00000517679.1_Silent_p.I67I|TBCA_ENST00000522370.1_Silent_p.I32I|TBCA_ENST00000306388.6_Silent_p.I56I|TBCA_ENST00000518338.2_Silent_p.I79I			O75347	TBCA_HUMAN	tubulin folding cofactor A	0					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway|tubulin complex assembly	cytoplasm|microtubule	chaperone binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)|ovary(1)	5		all_lung(232;0.000511)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;1.02e-49)|Epithelial(54;1.05e-44)|all cancers(79;4.08e-40)		ATTCTTGTAGGATCTCTGCCT	0.423000													6	47					0	0	1	0	0
TRBV6-5	28602	broad.mit.edu	37	7	142180727	142180727	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142180727C>T	ENST00000390368.2	-	0	197																											GGTTCATATCCTGGGCACACT	0.512000													29	465					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096388	167096388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167096388G>A	ENST00000361200.2	+	6	2186	c.2020G>A	c.(2020-2022)Gac>Aac	p.D674N	DUSP27_ENST00000443333.1_Missense_Mutation_p.D674N|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.D674N			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	674					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CGCTGATGGGGACACGACGTC	0.632000													7	45					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367888	107367888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107367888G>A	ENST00000542196.1	-	1	63	c.21C>T	c.(19-21)acC>acT	p.T7T		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CCACCAGAATGGTGTGGTTTT	0.368000													22	88					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072540	17072540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17072540C>T	ENST00000359963.3	-	1	1160	c.901G>A	c.(901-903)Gag>Aag	p.E301K		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	301					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGGGTCTCCTCGTCGACCTCC	0.493000													81	168					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37407121	37407121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37407121G>A	ENST00000403892.3	-	2	1575	c.841C>T	c.(841-843)Cgc>Tgc	p.R281C	TST_ENST00000249042.3_Missense_Mutation_p.R281C	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	281	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						GGGGCCCGGCGAAACCACTCG	0.642000													46	93					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35833903	35833903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:35833903G>A	ENST00000187397.4	+	19	2518	c.2062G>A	c.(2062-2064)Gga>Aga	p.G688R	ARPP21_ENST00000458225.1_Missense_Mutation_p.G689R|ARPP21_ENST00000417925.1_Missense_Mutation_p.G689R|ARPP21_ENST00000476052.1_3'UTR|ARPP21_ENST00000444190.1_Missense_Mutation_p.G669R|ARPP21_ENST00000337271.5_Missense_Mutation_p.G669R	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	688	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						TGGTCAACAGGGATTCCAAGG	0.468000													72	184					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	239990214	239990214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:239990214G>A	ENST00000345617.3	-	23	3616	c.2825C>T	c.(2824-2826)cCt>cTt	p.P942L	HDAC4_ENST00000543185.1_Missense_Mutation_p.P526L	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	942	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GCCCCCAAGAGGGGTGGGGTG	0.597000													16	46					0	0	1	0	0
TRAPPC2L	51693	broad.mit.edu	37	16	88925146	88925146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:88925146C>T	ENST00000561840.1	+	2	113	c.35C>T	c.(34-36)tCg>tTg	p.S12L	TRAPPC2L_ENST00000564365.1_5'UTR|TRAPPC2L_ENST00000301021.3_Silent_p.V51V|TRAPPC2L_ENST00000565504.1_Silent_p.V51V|TRAPPC2L_ENST00000567312.1_Silent_p.V51V|TRAPPC2L_ENST00000568583.1_Silent_p.V51V|TRAPPC2L_ENST00000567895.1_Silent_p.V21V			Q9UL33	TPC2L_HUMAN	trafficking protein particle complex 2-like	0					ER to Golgi vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm				lung(4)|pancreas(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(80;0.0477)		AGGCCCTGGTCGACCAGAGGG	0.577000													13	52					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848916	73848916	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73848916G>A	ENST00000523207.1	+	3	1914	c.1326G>A	c.(1324-1326)cgG>cgA	p.R442R		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	442					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CTCTTGAGCGGGCCAAAAGGA	0.453000													26	83					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060446	54060446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54060446C>T	ENST00000312233.2	-	3	696	c.130G>A	c.(130-132)Gaa>Aaa	p.E44K		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	44					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GAGCTGGGTTCGCTGCCCAGA	0.726000													3	16					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31155153	31155153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31155153G>A	ENST00000268281.4	-	7	784	c.726C>T	c.(724-726)gaC>gaT	p.D242D	PRSS36_ENST00000569305.1_Silent_p.D242D|PRSS36_ENST00000418068.2_Silent_p.D242D	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	242	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						GCCCCCCAGAGTCACCCTAGT	0.597000													6	53					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140407020	140407020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140407020C>T	ENST00000286349.3	+	3	1687	c.1496C>T	c.(1495-1497)tCc>tTc	p.S499F		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	499						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AAGGTACGCTCCTCAGGGGAC	0.572000													24	50					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8987264	8987264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8987264C>T	ENST00000397910.4	-	68	42026	c.41823G>A	c.(41821-41823)atG>atA	p.M13941I	MUC16_ENST00000380951.5_Missense_Mutation_p.M582I	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13966	SEA 13.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CGGGTTGGCCCATGTCCGCCA	0.602000													9	41					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151751443	151751443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151751443G>A	ENST00000368822.1	-	6	1234	c.601C>T	c.(601-603)Cgg>Tgg	p.R201W	TDRKH_ENST00000440583.2_5'UTR|TDRKH_ENST00000458431.2_Missense_Mutation_p.R201W|TDRKH_ENST00000368823.1_Missense_Mutation_p.R197W|TDRKH_ENST00000368827.6_Missense_Mutation_p.R201W|TDRKH_ENST00000368825.3_Missense_Mutation_p.R156W|TDRKH_ENST00000368824.3_Missense_Mutation_p.R201W|TDRKH_ENST00000484421.1_5'UTR			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	201							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ATTCTCTTCCGAAGTTCTTCA	0.453000													31	95					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57641670	57641670	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57641670G>A	ENST00000254181.4	+	4	2081	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K	USP29_ENST00000598197.1_Missense_Mutation_p.E543K	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	543					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTATTGCAATGAAAGCACCAA	0.418000													77	171					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067224	9067224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9067224G>A	ENST00000397910.4	-	3	20425	c.20222C>T	c.(20221-20223)cCt>cTt	p.P6741L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6743	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCAAGAGGAGGACCTGTTCG	0.502000													68	200					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582174	82582174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82582174G>A	ENST00000423517.2	-	5	8432	c.8095C>T	c.(8095-8097)Cct>Tct	p.P2699S	PCLO_ENST00000333891.8_Missense_Mutation_p.P2699S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2630					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGCTCTGGAGGAATTGTTATG	0.403000													17	44					0	0	1	0	0
C1orf105	92346	broad.mit.edu	37	1	172425563	172425563	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:172425563G>A	ENST00000367727.4	+	4	405	c.207G>A	c.(205-207)agG>agA	p.R69R	C1orf105_ENST00000367725.4_Silent_p.R59R|C1orf105_ENST00000367726.1_Intron	NM_139240.3	NP_640333.3	O95561	CA105_HUMAN	chromosome 1 open reading frame 105	69										large_intestine(1)|lung(12)|prostate(1)|skin(1)	15						AGGCCAGGAGGAACCAGTGTG	0.532000													51	142					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027567	37027567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37027567C>T	ENST00000358047.3	+	1	1136	c.1084C>T	c.(1084-1086)Cgc>Tgc	p.R362C		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	362										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCCAGAGACTCGCGTATCTCC	0.647000													39	59					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065427	35065427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35065427C>T	ENST00000382002.5	-	10	2059	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K	PRLR_ENST00000511486.1_Missense_Mutation_p.E444K|PRLR_ENST00000310101.5_3'UTR|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.E444K|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	545					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTGGCATACTCCTTATTGTTC	0.478000													19	75					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233346338	233346338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233346338C>T	ENST00000304546.1	-	14	2077	c.1867G>A	c.(1867-1869)Ggc>Agc	p.G623S	ECEL1_ENST00000409941.1_Missense_Mutation_p.G621S	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	623					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCATACTGGCCCCCTGTGGGC	0.652000													11	27					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50557805	50557805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50557805C>T	ENST00000267845.3	-	1	418	c.16G>A	c.(16-18)Gag>Aag	p.E6K	HDC_ENST00000543581.1_Missense_Mutation_p.E6K	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	6					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TCTCTGTACTCCTCAGGCTCC	0.617000													15	28					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70461449	70461449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:70461449C>T	ENST00000327305.6	-	6	1199	c.542G>A	c.(541-543)gGa>gAa	p.G181E	NETO1_ENST00000299430.2_Missense_Mutation_p.G180E|NETO1_ENST00000583169.1_Missense_Mutation_p.G181E	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	181	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CTCCACAATTCCTTCGGAACC	0.428000													34	65					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38051317	38051317	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:38051317C>T	ENST00000357436.4	+	18	2045	c.1732C>T	c.(1732-1734)Ccc>Tcc	p.P578S	SH3BP1_ENST00000599616.1_Intron|Z83844.1_ENST00000456099.1_RNA	NM_018957.3	NP_061830.3	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	578					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					CATGCCGCCCCCCCAGGTCTC	0.721000													8	14					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305062	61305062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61305062G>A	ENST00000341074.5	-	8	1179	c.1064C>T	c.(1063-1065)tCa>tTa	p.S355L	SERPINB4_ENST00000356424.6_Missense_Mutation_p.S303L	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TGAAGGAGATGATAATTCGAC	0.448000													42	107					0	0	1	0	0
CNIH3	149111	broad.mit.edu	37	1	224804900	224804900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:224804900C>T	ENST00000272133.3	+	1	906	c.24C>T	c.(22-24)ttC>ttT	p.F8F		NM_152495.1	NP_689708.1	Q8TBE1	CNIH3_HUMAN	cornichon family AMPA receptor auxiliary protein 3	8					intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane				large_intestine(5)|lung(4)	9	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		TCGCTGCGTTCTGCTACATGC	0.597000													96	375					0	0	1	0	0
KATNAL1	84056	broad.mit.edu	37	13	30854256	30854256	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:30854256T>A	ENST00000380615.3	-	3	434	c.267A>T	c.(265-267)caA>caT	p.Q89H	KATNAL1_ENST00000380617.3_Missense_Mutation_p.Q89H	NM_032116.4	NP_115492.1	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	89						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)|urinary_tract(3)	19		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		ATGGTTCATCTTGACAGGACA	0.393000													15	33					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169049298	169049298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169049298G>A	ENST00000359299.3	+	2	268	c.82G>A	c.(82-84)Gga>Aga	p.G28R		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	28							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		AATGCTAGGAGGAGCACTCCA	0.368000													5	54					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113352931	113352931	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113352931C>T	ENST00000458497.1	+	11	2507	c.2228C>T	c.(2227-2229)gCc>gTc	p.A743V	ALPK1_ENST00000177648.9_Missense_Mutation_p.A743V|ALPK1_ENST00000504176.2_Missense_Mutation_p.A665V	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	743							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AAAGAAGAAGCCTTTGAAATA	0.468000													27	71					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145110780	145110780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145110780G>A	ENST00000426825.1	-	16	2240	c.2159C>T	c.(2158-2160)tCc>tTc	p.S720F	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	720							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GGCCCCCACGGAGATGCAGAT	0.647000													3	12					0	0	1	0	0
CEACAM21	90273	broad.mit.edu	37	19	42085862	42085862	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42085862G>A	ENST00000407170.2	+	4	1010	c.197G>A	c.(196-198)tGg>tAg	p.W66*	CEACAM21_ENST00000401445.2_Nonsense_Mutation_p.W194*|CEACAM21_ENST00000187608.9_Nonsense_Mutation_p.W194*|CEACAM21_ENST00000482870.2_3'UTR			Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	194						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						AAGCTGTCCTGGTTTAACCAT	0.542000													7	25					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233749941	233749941	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233749941C>T	ENST00000366621.3	+	1	192	c.24C>T	c.(22-24)agC>agT	p.S8S		NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	8						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TGGCCGGCAGCTCGTGCGTGC	0.721000													7	20					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76471399	76471399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76471399C>T	ENST00000389840.5	-	54	8554	c.8430G>A	c.(8428-8430)caG>caA	p.Q2810Q	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.Q2819Q					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGAGGGTGATCTGAAACACGT	0.587000													26	99					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63517664	63517664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63517664C>T	ENST00000377819.5	+	4	2886	c.2732C>T	c.(2731-2733)cCa>cTa	p.P911L	RTN3_ENST00000540798.1_Missense_Mutation_p.P799L|RTN3_ENST00000339997.4_Missense_Mutation_p.P892L|RTN3_ENST00000341307.2_Missense_Mutation_p.P115L|RTN3_ENST00000356000.3_Missense_Mutation_p.P134L|RTN3_ENST00000354497.4_Missense_Mutation_p.P115L|RTN3_ENST00000537981.1_Missense_Mutation_p.P115L	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	911	Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						GAAGGCCATCCATTCAAGTGA	0.428000													7	17					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35945118	35945118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35945118G>A	ENST00000490799.1	-	9	1389	c.1036C>T	c.(1036-1038)Cct>Tct	p.P346S	SLC26A8_ENST00000394602.2_Missense_Mutation_p.P241S|SLC26A8_ENST00000355574.2_Missense_Mutation_p.P346S	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	346					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						GGTGTTACAGGAAGCAGAAAG	0.423000													23	85					0	0	1	0	0
PPP1R3D	5509	broad.mit.edu	37	20	58514657	58514657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:58514657G>A	ENST00000370996.3	-	1	695	c.330C>T	c.(328-330)ggC>ggT	p.G110G	FAM217B_ENST00000358293.3_Intron	NM_006242.3	NP_006233.1	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	110					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|urinary_tract(1)	13	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			CCAGCTCCAAGCCCAGGGCGT	0.726000													10	25					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3687253	3687253	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3687253C>T	ENST00000344754.4	-	2	149	c.150G>A	c.(148-150)gaG>gaA	p.E50E	SIGLEC1_ENST00000202578.4_Silent_p.E50E	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	50	Ig-like V-type.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CGTCGGGCACCTCCACGTCGG	0.667000													3	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179469545	179469545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179469545C>T	ENST00000589042.1	-	281	54495	c.54271G>A	c.(54271-54273)Gat>Aat	p.D18091N	TTN_ENST00000342992.6_Missense_Mutation_p.D15523N|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D16450N|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D9218N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D9151N|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D9026N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16450	Fibronectin type-III 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACCATTATCAAGAGGGGCA	0.448000													26	56					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40760984	40760984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40760984C>T	ENST00000216194.7	+	12	1348	c.1292C>T	c.(1291-1293)gCc>gTc	p.A431V	ADSL_ENST00000342312.6_Intron|ADSL_ENST00000454266.2_Missense_Mutation_p.A445V	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	431					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						CAGGTTGATGCCTACTTCAGT	0.488000													10	186					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26736598	26736598	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26736598G>A	ENST00000529632.2	+	10	2408	c.2212_splice	c.e10+1	p.E738_splice	SEZ6L_ENST00000360929.3_Splice_Site_p.E738_splice|SEZ6L_ENST00000402979.1_Splice_Site_p.E511_splice|SEZ6L_ENST00000404234.3_Splice_Site_p.E738_splice|SEZ6L_ENST00000343706.4_Splice_Site_p.E738_splice|SEZ6L_ENST00000403121.1_Splice_Site_p.E511_splice|SEZ6L_ENST00000248933.6_Splice_Site_p.E738_splice	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	738	CUB 3.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GAACTACATAGGTAGGTGTCT	0.428000													7	49					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328333	80328333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:80328333G>A	ENST00000358842.3	-	1	1039	c.1022C>T	c.(1021-1023)aCc>aTc	p.T341I		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	341					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						GTCTCCTGAGGTCTCTATAAT	0.438000													54	138					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	48994003	48994003	+	Missense_Mutation	SNP	T	T	C	rs146104899	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48994003T>C	ENST00000226432.4	+	4	590	c.407T>C	c.(406-408)cTa>cCa	p.L136P	CWH43_ENST00000513409.1_Missense_Mutation_p.L109P	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	136					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						CTTGTTGTTCTACGCATATGG	0.373000													26	69					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81647096	81647096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81647096C>T	ENST00000548058.1	+	14	2640	c.1730C>T	c.(1729-1731)tCc>tTc	p.S577F	ACSS3_ENST00000548324.1_Missense_Mutation_p.S259F|ACSS3_ENST00000261206.3_Missense_Mutation_p.S576F			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	577						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TCAATCCTTTCCCATGGTACC	0.363000													26	199					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47463708	47463708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47463708G>A	ENST00000398879.1	-	10	830	c.464C>T	c.(463-465)tCc>tTc	p.S155F	TNS3_ENST00000458317.2_Missense_Mutation_p.S155F|TNS3_ENST00000442536.2_Missense_Mutation_p.S155F|TNS3_ENST00000311160.9_Missense_Mutation_p.S155F|TNS3_ENST00000355730.3_Missense_Mutation_p.S155F			Q68CZ2	TENS3_HUMAN	tensin 3	155	Phosphatase tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CCGTTTTTGGGAAGGCTGCAT	0.433000													18	77					0	0	1	0	0
TMEM117	84216	broad.mit.edu	37	12	44782277	44782277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:44782277C>T	ENST00000266534.3	+	8	1494	c.1367C>T	c.(1366-1368)tCa>tTa	p.S456L	TMEM117_ENST00000536799.1_Missense_Mutation_p.S352L|TMEM117_ENST00000546978.1_3'UTR|TMEM117_ENST00000551577.1_3'UTR	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	456						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		ACCCAGGCTTCAGTAGAAGAC	0.443000													60	95					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432190	140432190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140432190G>A	ENST00000306549.3	+	1	1212	c.1135G>A	c.(1135-1137)Gga>Aga	p.G379R		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		379	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATTCGAGTGGGAGGAAAAGT	0.498000													29	53					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3638665	3638665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3638665C>T	ENST00000378295.4	+	5	665	c.510C>T	c.(508-510)ccC>ccT	p.P170P	TP73_ENST00000346387.4_Silent_p.P170P|TP73_ENST00000604074.1_Silent_p.P170P|TP73_ENST00000378280.1_Silent_p.P121P|TP73_ENST00000378290.4_Silent_p.P99P|TP73_ENST00000378285.1_Silent_p.P121P|TP73_ENST00000603362.1_Silent_p.P170P|TP73_ENST00000378288.4_Silent_p.P121P|TP73_ENST00000357733.3_Silent_p.P170P|TP73_ENST00000604479.1_Silent_p.P170P|TP73_ENST00000354437.4_Silent_p.P170P	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	170	DNA-binding (Potential).|Poly-Pro.				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CCCCGCCACCCCCAGGCACCG	0.617000													24	79					0	0	1	0	0
GCNT3	9245	broad.mit.edu	37	15	59911343	59911343	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:59911343C>T	ENST00000396065.1	+	3	1354	c.906C>T	c.(904-906)tcC>tcT	p.S302S	GCNT3_ENST00000560585.1_Silent_p.S302S	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	302					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TTGTGGCTTCCCGAGATTTCG	0.433000													70	167					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15807281	15807281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15807281G>A	ENST00000550308.1	+	12	1736	c.1356G>A	c.(1354-1356)ggG>ggA	p.G452G	CYP4F12_ENST00000324632.9_Silent_p.G452G	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ACAGCAAGGGGAGGTCACCTC	0.552000													49	170					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202617958	202617958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202617958G>A	ENST00000264276.6	-	7	2020	c.1648C>T	c.(1648-1650)Ccg>Tcg	p.P550S		NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	550					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						ACACACAACGGTTGAAGCCTT	0.413000													34	70					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68405287	68405287	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68405287C>T	ENST00000219334.5	-	3	1401	c.798G>A	c.(796-798)caG>caA	p.Q266Q	SMPD3_ENST00000563226.1_Silent_p.Q266Q|SMPD3_ENST00000568373.1_Silent_p.Q266Q	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	266					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CGTTCCTGGCCTGGCCCCCAG	0.716000													4	30					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53216853	53216853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53216853G>A	ENST00000330553.5	-	7	1348	c.1314C>T	c.(1312-1314)gcC>gcT	p.A438A		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	438	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCACGTCCAGGGCCAGCTTGA	0.632000													28	71					0	0	1	0	0
ZNF768	79724	broad.mit.edu	37	16	30536515	30536515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30536515G>A	ENST00000380412.5	-	2	1121	c.946C>T	c.(946-948)Ccc>Tcc	p.P316S	ZNF768_ENST00000562803.1_Missense_Mutation_p.P285S	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	316					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						CATTTGTAGGGCCGCTCGCCA	0.607000													6	76					0	0	1	0	0
SNTB2	6645	broad.mit.edu	37	16	69317986	69317986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:69317986C>T	ENST00000336278.4	+	5	1222	c.1184C>T	c.(1183-1185)tCc>tTc	p.S395F		NM_006750.3	NP_006741.1	Q13425	SNTB2_HUMAN	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	395	PH 2.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)		CGATCCCCCTCCCTTGGATCT	0.483000													28	123					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233313560	233313560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233313560C>T	ENST00000258229.8	-	17	3495	c.3261G>A	c.(3259-3261)atG>atA	p.M1087I	PCNXL2_ENST00000488780.2_Missense_Mutation_p.M220I	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1087						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CTGAATCTTTCATCTTCTTGG	0.463000													15	33					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416375	29416375	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29416375C>T	ENST00000389048.3	-	29	5484	c.4578G>A	c.(4576-4578)gaG>gaA	p.E1526E	ALK_ENST00000431873.1_Silent_p.E356E	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1526					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGTCGTGTGGCTCCTTCTTTG	0.547000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				91	242					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308496	248308496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248308496G>A	ENST00000366476.1	+	1	47	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ATCCTCCTGGGAATCTTCAAT	0.443000													111	265					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953626	140953626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140953626C>T	ENST00000277549.5	+	31	4726	c.2157C>T	c.(2155-2157)atC>atT	p.I719I	CACNA1B_ENST00000371357.1_Silent_p.I1524I|CACNA1B_ENST00000371363.1_Silent_p.I1523I|CACNA1B_ENST00000277551.2_Silent_p.I1523I|CACNA1B_ENST00000371355.4_Silent_p.I1524I|CACNA1B_ENST00000371372.1_Silent_p.I1523I			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1523					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGAAGATCATCGCCTTTGGGG	0.502000													4	12					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21120193	21120193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21120193C>T	ENST00000377122.4	-	16	1999	c.1603G>A	c.(1603-1605)Gga>Aga	p.G535R	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	535					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ACTTGCATTCCTTTCCCTTTA	0.368000													6	74					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645218	52645218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:52645218G>A	ENST00000395961.3	-	4	602	c.436C>T	c.(436-438)Ccg>Tcg	p.P146S	BCAS1_ENST00000371435.2_Missense_Mutation_p.P146S|BCAS1_ENST00000371440.3_Missense_Mutation_p.P146S|BCAS1_ENST00000411563.1_Missense_Mutation_p.P49S	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	146						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TCCTGCCCCGGTCCAGCTGCC	0.592000													27	62					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89650480	89650480	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89650480C>T	ENST00000268720.5	+	6	832	c.702C>T	c.(700-702)ctC>ctT	p.L234L	CPNE7_ENST00000319518.8_Silent_p.L159L	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	234					lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		ACGTGGAGCTCTCCTTCCGGG	0.687000													9	44					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26414504	26414504	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26414504T>A	ENST00000265944.5	+	19	2247	c.2081T>A	c.(2080-2082)aTt>aAt	p.I694N	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	694	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GTCAATTGCATTAACAGTTTG	0.348000													13	139					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	628613	628613	+	Missense_Mutation	SNP	G	G	A	rs140444984		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:628613G>A	ENST00000255622.6	+	2	659	c.616G>A	c.(616-618)Gaa>Aaa	p.E206K	PDE6B_ENST00000496514.1_Missense_Mutation_p.E206K	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	206	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						CAGCGAAGACGAAGATGTGAG	0.602000													19	45					0	0	1	0	0
AMPD2	271	broad.mit.edu	37	1	110168355	110168355	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110168355C>T	ENST00000256578.3	+	3	816	c.456C>T	c.(454-456)ccC>ccT	p.P152P	AMPD2_ENST00000393688.3_Silent_p.P33P|AMPD2_ENST00000526301.1_3'UTR|AMPD2_ENST00000358729.4_Silent_p.P77P|AMPD2_ENST00000528667.1_Silent_p.P152P|AMPD2_ENST00000528454.1_Silent_p.P34P|AMPD2_ENST00000342115.4_Silent_p.P71P	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	152					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		AGGAGAGCCCCATTGAACAGC	0.642000													20	71					0	0	1	0	0
AGTRAP	57085	broad.mit.edu	37	1	11808498	11808498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11808498C>T	ENST00000376637.3	+	3	285	c.160C>T	c.(160-162)Ctt>Ttt	p.L54F	AGTRAP_ENST00000510878.1_Missense_Mutation_p.S30F|AGTRAP_ENST00000491346.1_3'UTR|AGTRAP_ENST00000314340.5_Silent_p.I65I|AGTRAP_ENST00000376629.4_Silent_p.I65I|AGTRAP_ENST00000400895.2_Missense_Mutation_p.L98F|AGTRAP_ENST00000376627.2_Missense_Mutation_p.L110F|AGTRAP_ENST00000452018.2_Missense_Mutation_p.L98F	NM_001040195.1	NP_001035285.1	Q6RW13	ATRAP_HUMAN	angiotensin II receptor-associated protein	0						cytoplasmic vesicle membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding		AGTRAP/BRAF(2)	endometrium(1)|lung(3)|prostate(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.46e-06)|COAD - Colon adenocarcinoma(227;0.000256)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCCACCATCTTCCTGGACA	0.627000													21	57					0	0	1	0	0
TMEM178A	130733	broad.mit.edu	37	2	39931233	39931233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:39931233G>A	ENST00000281961.2	+	2	469	c.413G>A	c.(412-414)cGa>cAa	p.R138Q	TMEM178A_ENST00000482239.1_3'UTR	NM_152390.2	NP_689603.2			transmembrane protein 178A																		ATTGCGCAGCGATGCACGGCC	0.448000													11	42					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70938399	70938399	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70938399T>C	ENST00000334414.6	-	22	5476	c.5432A>G	c.(5431-5433)aAg>aGg	p.K1811R	PTPRB_ENST00000550358.1_Missense_Mutation_p.K1723R|PTPRB_ENST00000261266.5_Missense_Mutation_p.K1593R|PTPRB_ENST00000451516.2_Missense_Mutation_p.K1503R|PTPRB_ENST00000538708.1_Missense_Mutation_p.K1503R|PTPRB_ENST00000550857.1_Missense_Mutation_p.K1503R	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1593	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGTGAATTCCTTCAGGTCCTC	0.363000													4	55					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31332622	31332622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31332622G>A	ENST00000544665.3	+	15	1842	c.1771G>A	c.(1771-1773)Ggc>Agc	p.G591S	ITGAM_ENST00000287497.8_Missense_Mutation_p.G590S	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	590					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						ACTGAGTGGGGGCCAGGACCT	0.562000													35	140					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529548	57529548	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:57529548G>T	ENST00000420713.1	+	4	1493	c.1381G>T	c.(1381-1383)Gag>Tag	p.E461*		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TCATACTGGAGAGAAACCCTA	0.358000													7	10					2.0095e-06	2.01364e-06	1	1	0
GRB7	2886	broad.mit.edu	37	17	37898880	37898880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37898880G>A	ENST00000309156.4	+	3	474	c.217G>A	c.(217-219)Gag>Aag	p.E73K	GRB7_ENST00000394209.2_Missense_Mutation_p.E73K|GRB7_ENST00000394211.3_Missense_Mutation_p.E73K|GRB7_ENST00000394204.1_Missense_Mutation_p.E73K|GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000445327.2_Missense_Mutation_p.E96K|GRB7_ENST00000309185.3_Missense_Mutation_p.E73K	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	73					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCCCTTCCCTGAGCTCTGCAG	0.637000													33	96					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94772575	94772575	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94772575G>A	ENST00000283357.5	+	7	904	c.858G>A	c.(856-858)ggG>ggA	p.G286G		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	286										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		TGGTCCAGGGGGATTATCGCC	0.398000													18	50					0	0	1	0	0
TTLL9	164395	broad.mit.edu	37	20	30510853	30510853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30510853G>A	ENST00000375938.4	+	8	914	c.661G>A	c.(661-663)Gga>Aga	p.G221R	TTLL9_ENST00000375921.2_Missense_Mutation_p.G148R|TTLL9_ENST00000535842.1_Missense_Mutation_p.G221R|TTLL9_ENST00000310998.4_Missense_Mutation_p.G171R|TTLL9_ENST00000375922.4_Missense_Mutation_p.G148R|TTLL9_ENST00000375934.4_Missense_Mutation_p.G203R			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	221	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TTACCTGATAGGAGGTGAGAT	0.483000													27	73					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881391	26881391	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:26881391C>A	ENST00000231021.4	-	12	2396	c.2224G>T	c.(2224-2226)Ggg>Tgg	p.G742W		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	742					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GAATCATTCCCTTCATAGGCA	0.418000													32	122					6.00712e-18	6.04191e-18	1	1	0
MUC16	94025	broad.mit.edu	37	19	9067623	9067623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9067623G>A	ENST00000397910.4	-	3	20026	c.19823C>T	c.(19822-19824)tCg>tTg	p.S6608L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6610	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGACAGACGAATAAGATTC	0.443000													18	214					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304663	10304663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10304663G>A	ENST00000403437.2	-	24	3131	c.3037C>T	c.(3037-3039)Ctg>Ttg	p.L1013L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1013					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCTGCCTGCAGGTCATCCAGG	0.458000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				86	119					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404233	20404233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20404233G>A	ENST00000285600.4	+	1	467	c.408G>A	c.(406-408)atG>atA	p.M136I		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GTACAATTATGAACCGGAGGC	0.443000													33	82					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56525338	56525338	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56525338C>T	ENST00000394048.5	+	6	1056	c.792C>T	c.(790-792)ttC>ttT	p.F264F	ESYT1_ENST00000541590.1_Silent_p.F264F|ESYT1_ENST00000267113.4_Silent_p.F264F	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	264						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						CAATGTTCTTCATCCGACGCC	0.537000													49	140					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1562297	1562297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1562297C>T	ENST00000357210.4	+	10	1548	c.1332C>T	c.(1330-1332)acC>acT	p.T444T	MIB2_ENST00000360522.4_Silent_p.T409T|MIB2_ENST00000520777.1_Silent_p.T497T|MIB2_ENST00000518681.1_Silent_p.T436T|MIB2_ENST00000505820.2_Silent_p.T501T|MIB2_ENST00000378710.3_Silent_p.T408T|MIB2_ENST00000355826.5_Silent_p.T487T|MIB2_ENST00000378712.1_Silent_p.T321T|MIB2_ENST00000504599.1_Silent_p.T400T|MIB2_ENST00000378708.1_Silent_p.T350T	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	444					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGCGGTGGACCTTCAGCCCCT	0.687000													9	14					0	0	1	0	0
KLRC2	3822	broad.mit.edu	37	12	10584713	10584713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10584713G>A	ENST00000381902.2	-	5	582	c.576C>T	c.(574-576)ttC>ttT	p.F192F	KLRC2_ENST00000536833.2_Silent_p.F133F|KLRC2_ENST00000381901.1_Silent_p.F192F|NKG2-E_ENST00000539033.1_Intron	NM_002260.3	NP_002251.2	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C, member 2	192	C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity			kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11						ACTTATGTTTGAAAGCCAAAC	0.313000													7	36					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5757959	5757959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5757959C>T	ENST00000317121.3	+	1	279	c.213C>T	c.(211-213)ttC>ttT	p.F71F	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		TGTATATTTTCCTTGGCATCC	0.493000													16	50					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116045904	116045904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116045904G>A	ENST00000603594.1	+	11	1525	c.1204G>A	c.(1204-1206)Gat>Aat	p.D402N	VWA2_ENST00000392982.3_Missense_Mutation_p.D402N	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	402	VWFA 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GGAGTACCAGGATGTGCCTGA	0.682000													19	69					0	0	1	0	0
RP11-159L20.2	0	broad.mit.edu	37	14	31290653	31290653	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:31290653C>T	ENST00000554665.1	-	0	208																											GGGCAAGTTCCTGAAACCTCG	0.473000													12	38					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247835510	247835510	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247835510C>T	ENST00000359688.2	-	1	855	c.834G>A	c.(832-834)gtG>gtA	p.V278V	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V278V(2)		endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATGTGGGAGTCACAAGAGTAT	0.438000													11	122					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62195402	62195402	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62195402G>A	ENST00000467148.1	-	8	4842	c.4773C>T	c.(4771-4773)ccC>ccT	p.P1591P	HELZ2_ENST00000427522.2_Silent_p.P1022P	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GCGTGTCGGGGGGACTGCCCC	0.687000													4	10					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060477	54060477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54060477G>A	ENST00000312233.2	-	3	665	c.99C>T	c.(97-99)acC>acT	p.T33T		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	33					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						AAGGCGCAGGGGTGGCGAGGC	0.721000													3	21					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156814576	156814576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156814576G>A	ENST00000368195.3	-	13	2893	c.2497C>T	c.(2497-2499)Ctt>Ttt	p.L833F	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	833	Fibronectin type-III 3.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGCGCAGAAGGACACTGTTC	0.617000													22	55					0	0	1	0	0
PPA2	27068	broad.mit.edu	37	4	106367581	106367581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:106367581G>A	ENST00000341695.5	-	5	430	c.400C>T	c.(400-402)Cct>Tct	p.P134S	PPA2_ENST00000380004.2_Missense_Mutation_p.P116S|PPA2_ENST00000354147.3_Intron|PPA2_ENST00000310267.7_Missense_Mutation_p.P55S|PPA2_ENST00000509426.1_5'UTR|PPA2_ENST00000357415.4_Missense_Mutation_p.P149S|PPA2_ENST00000348706.5_Missense_Mutation_p.P134S|PPA2_ENST00000432483.2_Intron	NM_176869.2	NP_789845.1	Q9H2U2	IPYR2_HUMAN	pyrophosphatase (inorganic) 2	134					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	11		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)		CCCTTGTAAGGGAAGATATTC	0.373000													12	144					0	0	1	0	0
EIF2D	1939	broad.mit.edu	37	1	206778857	206778857	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:206778857G>A	ENST00000271764.2	-	5	634	c.426C>T	c.(424-426)gcC>gcT	p.A142A	EIF2D_ENST00000367114.3_Silent_p.A142A	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	142	PUA.				intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						TGGCTACAGGGGCTCTAAGAA	0.512000													9	25					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105459626	105459626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:105459626C>T	ENST00000351513.2	-	3	661	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	177					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGAAGGCTTCGTACAGCTCC	0.428000													16	65					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90008191	90008191	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90008191C>T	ENST00000405460.2	+	42	9226	c.9130C>T	c.(9130-9132)Cag>Tag	p.Q3044*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3044	Calx-beta 21.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGAAAAATTTCAGCTGATTTT	0.343000													4	12					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39156146	39156146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39156146C>T	ENST00000301819.6	+	6	806	c.629C>T	c.(628-630)tCa>tTa	p.S210L	TTC21A_ENST00000431162.2_Missense_Mutation_p.S210L|TTC21A_ENST00000440121.1_Missense_Mutation_p.S169L	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	210							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		ACTGTGACTTCAGGGAGCTTC	0.552000													47	105					0	0	1	0	0
RALYL	138046	broad.mit.edu	37	8	85799849	85799849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:85799849G>A	ENST00000521268.1	+	8	1801	c.696G>A	c.(694-696)aaG>aaA	p.K232K	RALYL_ENST00000517638.1_Silent_p.K245K|RALYL_ENST00000521376.1_Intron|RALYL_ENST00000518566.1_Silent_p.K221K|RALYL_ENST00000521695.1_Silent_p.K232K|RALYL_ENST00000523850.1_Silent_p.K159K|RALYL_ENST00000522455.1_Silent_p.K232K	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	232							identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						AAGCTCAGAAGAAGCAATTGG	0.483000													5	67					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73567144	73567144	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73567144C>T	ENST00000392550.3	+	17	2256	c.2139C>T	c.(2137-2139)gtC>gtT	p.V713V	LLGL2_ENST00000167462.5_Silent_p.V713V|LLGL2_ENST00000577200.1_Silent_p.V713V	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	713					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CAGGCTTCGTCCGGACCCTGT	0.652000													51	119					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144942348	144942348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144942348C>T	ENST00000525985.1	-	2	5145	c.5074G>A	c.(5074-5076)Gac>Aac	p.D1692N				P58107	EPIPL_HUMAN	epiplakin 1	1692						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCACGGGGTCGATGATGCCG	0.677000													32	68					0	0	1	0	0
TLE6	79816	broad.mit.edu	37	19	2989206	2989206	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2989206C>T	ENST00000246112.4	+	12	1089	c.888C>T	c.(886-888)agC>agT	p.S296S	TLE6_ENST00000478073.2_3'UTR|TLE6_ENST00000452088.1_Silent_p.S173S	NM_001143986.1	NP_001137458.1	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)	173					regulation of transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCATCAGCAGCTTCACGCGGC	0.617000													13	34					0	0	1	0	0
S1PR3	1903	broad.mit.edu	37	9	91616901	91616901	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:91616901C>T	ENST00000375846.3	+	1	5481	c.786C>T	c.(784-786)ctC>ctT	p.L262L	S1PR3_ENST00000358157.2_Silent_p.L262L			Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	262					anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(1)	34						TCTTCATCCTCTTCCTCATTG	0.597000													22	29					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79429947	79429947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79429947C>T	ENST00000264895.6	+	63	10007	c.9567C>T	c.(9565-9567)tcC>tcT	p.S3189S		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3184					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCAAGAAATCCCCCTCCCCAG	0.547000													9	21					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156289882	156289882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156289882C>T	ENST00000311277.4	-	5	827	c.564G>A	c.(562-564)atG>atA	p.M188I	AC097467.2_ENST00000596165.1_RNA|MAP9_ENST00000379248.2_Missense_Mutation_p.M115I|MAP9_ENST00000515654.1_Missense_Mutation_p.M188I|AC097467.2_ENST00000597831.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	188					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CCTTCTCCTCCATGTGACTTT	0.413000													12	101					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220167069	220167069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220167069C>T	ENST00000295718.2	-	6	1024	c.784G>A	c.(784-786)Ggg>Agg	p.G262R	PTPRN_ENST00000409251.3_Missense_Mutation_p.G262R|AC114803.3_ENST00000417355.1_RNA|PTPRN_ENST00000423636.2_Missense_Mutation_p.G172R	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	262					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GGAAGGTCCCCGTAGGAGTGG	0.632000													9	18					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54554948	54554948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54554948C>T	ENST00000566473.2	+	15	1882	c.1882C>T	c.(1882-1884)Ctt>Ttt	p.L628F	ANKFN1_ENST00000318698.2_Missense_Mutation_p.L628F			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	628										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						AATCAAAGTTCTTGTTACCCA	0.393000													49	116					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30268851	30268851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:30268851G>A	ENST00000378981.3	+	4	562	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K	MAGEB1_ENST00000397548.2_Missense_Mutation_p.E81K|MAGEB1_ENST00000397550.1_Missense_Mutation_p.E81K	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	81										NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						CGAATCTGACGAAGGTGCCAA	0.557000													3	5					0	0	1	0	0
XKRX	402415	broad.mit.edu	37	X	100177947	100177947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:100177947C>T	ENST00000328526.5	-	2	1043	c.478G>A	c.(478-480)Gag>Aag	p.E160K	XKRX_ENST00000468904.1_Intron|XKRX_ENST00000372956.2_Missense_Mutation_p.E147K	NM_212559.2	NP_997724.2	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related, X-linked	147						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(3)	22						ATCAGCACCTCCTCGCCATCT	0.537000													71	60					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122759247	122759247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122759247G>A	ENST00000194130.2	-	13	1439	c.1400C>T	c.(1399-1401)tCa>tTa	p.S467L	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	467						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TGCTGGTAATGAACCCAGAGG	0.343000													16	58					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233410375	233410375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233410375G>A	ENST00000389494.3	+	12	1524	c.1503G>A	c.(1501-1503)ccG>ccA	p.P501P	CHRNG_ENST00000389492.3_Silent_p.P449P	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	501					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		ACCGGGTGCCGGCCCTGCCAT	0.632000													8	75					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94156635	94156635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94156635C>T	ENST00000553484.1	+	47	7595	c.7441C>T	c.(7441-7443)Cca>Tca	p.P2481S	UNC79_ENST00000555664.1_Missense_Mutation_p.P2420S|UNC79_ENST00000256339.4_Missense_Mutation_p.P2282S|UNC79_ENST00000393151.2_Missense_Mutation_p.P2459S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2459						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GATTGGATTTCCAGAGCAATC	0.453000													20	101					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227400880	227400880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:227400880G>A	ENST00000366769.3	-	3	1602	c.311C>T	c.(310-312)gCc>gTc	p.A104V	CDC42BPA_ENST00000366766.2_Missense_Mutation_p.A104V|CDC42BPA_ENST00000334218.5_Missense_Mutation_p.A104V|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.A104V|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.A104V|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.A104V|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.A104V	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	104	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				TATTTTCATGGCAAACACTTT	0.249000													15	108					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30572209	30572209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30572209C>T	ENST00000376511.2	-	13	1734	c.1182G>A	c.(1180-1182)agG>agA	p.R394R		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	394	Essential for PPP1CA inhibition (By similarity).|Necessary for interaction with PPP1CA (By similarity).|Necessary for interaction with PPP1CC.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						TTTTCCTCTTCCTGCCTTTCC	0.483000													57	132					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148932900	148932900	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:148932900G>A	ENST00000539543.1	+	0	156					NR_027355.1																						TCAGTCTGCGGCCAAGACTCC	0.612000													8	146					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170003441	170003441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170003441C>T	ENST00000263816.3	-	69	12904	c.12619G>A	c.(12619-12621)Gaa>Aaa	p.E4207K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4207					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATTTTAGGTTCCTTTCCCCAG	0.473000													12	33					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129847804	129847804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129847804G>A	ENST00000471218.1	+	5	348	c.289G>A	c.(289-291)Ggt>Agt	p.G97S	PTPRE_ENST00000254667.3_Silent_p.R98R|PTPRE_ENST00000430713.2_Silent_p.R98R|PTPRE_ENST00000306042.5_Silent_p.R40R|PTPRE_ENST00000419012.2_Silent_p.R98R			P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	0					negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				AGCAGCAAAGGGTGATGCTGC	0.542000													24	70					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5655066	5655066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5655066G>A	ENST00000354852.5	+	9	1691	c.1518G>A	c.(1516-1518)aaG>aaA	p.K506K	HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000514226.1_Silent_p.K152K|TRIM6-TRIM34_ENST00000457787.2_Silent_p.K152K|TRIM34_ENST00000429814.2_Silent_p.K152K	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		506						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		AGAGGCTGAAGAAGGAAGAGG	0.453000													9	53					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148614388	148614388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:148614388G>A	ENST00000296046.3	+	11	1200	c.1148G>A	c.(1147-1149)gGc>gAc	p.G383D	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	383					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding	p.G383V(1)		NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CGAGATAAAGGCAAATTTGGT	0.433000													55	66					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768823	57768823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57768823C>T	ENST00000371030.2	+	1	2749	c.2749C>T	c.(2749-2751)Ccc>Tcc	p.P917S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	917						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CGCAGAGCACCCCTCGCTGGC	0.632000													22	46					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47628897	47628897	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:47628897C>T	ENST00000546455.1	+	4	782	c.51C>T	c.(49-51)ttC>ttT	p.F17F	PCED1B_ENST00000432328.1_Silent_p.F17F					PC-esterase domain containing 1B									p.F17F(2)									ACAATAAGTTCGTGGTCATCC	0.592000													31	23					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126051160	126051160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:126051160G>A	ENST00000318410.7	-	25	3345	c.2996C>T	c.(2995-2997)tCa>tTa	p.S999L	KIAA0196_ENST00000517845.1_Missense_Mutation_p.S851L	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	999					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GTAAGGAAGTGAAGGGTCCTG	0.403000													24	133					0	0	1	0	0
ZNF569	148266	broad.mit.edu	37	19	37904945	37904945	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:37904945C>T	ENST00000316950.6	-	6	1172	c.615G>A	c.(613-615)ctG>ctA	p.L205L	ZNF569_ENST00000392150.2_Silent_p.L46L|ZNF569_ENST00000392149.2_Silent_p.L205L	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGAATTCTCAGATGTCTGA	0.363000													27	72					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8118269	8118269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8118269G>A	ENST00000305253.4	+	7	1009	c.768G>A	c.(766-768)gaG>gaA	p.E256E	TUB_ENST00000299506.2_Silent_p.E201E|TUB_ENST00000534099.1_Silent_p.E207E	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	201					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AGGATGAGGAGGATGAGGAGG	0.542000													18	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615810	179615810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179615810G>A	ENST00000360870.5	-	46	11539	c.11317C>T	c.(11317-11319)Cca>Tca	p.P3773S	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9610							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGGCATGTGGATTTTGCACA	0.348000													12	184					0	0	1	0	0
NXF2B	728343	broad.mit.edu	37	X	101620169	101620169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:101620169G>A	ENST00000457521.2	-	27	3148	c.1277C>T	c.(1276-1278)cCc>cTc	p.P426L	NXF2B_ENST00000372752.1_Missense_Mutation_p.P338L|NXF2B_ENST00000372750.1_Missense_Mutation_p.P426L|NXF2B_ENST00000489531.1_5'UTR|NXF2B_ENST00000372749.1_Missense_Mutation_p.P426L|NXF2B_ENST00000412230.2_Missense_Mutation_p.P426L					nuclear RNA export factor 2B											breast(1)|kidney(1)|lung(4)|ovary(1)	7						GGGGTCGAAGGGAATAGCCAA	0.572000													20	53					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226491723	226491723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:226491723C>T	ENST00000272907.6	+	5	2122	c.1709C>T	c.(1708-1710)tCc>tTc	p.S570F	NYAP2_ENST00000409269.2_Silent_p.F104F	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	570																	GGGGCGTCTTCCTCCAGAGAG	0.527000													5	12					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122631747	122631747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122631747G>A	ENST00000195173.4	-	18	2968	c.2665C>T	c.(2665-2667)Ctg>Ttg	p.L889L	SEMA5B_ENST00000451055.2_Silent_p.L944L|SEMA5B_ENST00000357599.3_Silent_p.L890L			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	890	TSP type-1 3.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		ACGCAGGGCAGGCCCCCGTTG	0.687000													42	76					0	0	1	0	0
C1QTNF3	114899	broad.mit.edu	37	5	34043182	34043182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:34043182G>A	ENST00000382065.3	-	1	755	c.49C>T	c.(49-51)Ctc>Ttc	p.L17F	C1QTNF3_ENST00000231338.7_Missense_Mutation_p.L17F	NM_181435.5	NP_852100.3	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	0						collagen				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|prostate(3)|stomach(1)|urinary_tract(1)	17	all_lung(31;0.0207)					CAAAAAGGGAGGAAAAACAAA	0.493000													54	160					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39963869	39963869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39963869C>T	ENST00000599117.1	+	25	2652	c.2285C>T	c.(2284-2286)aCc>aTc	p.T762I	SUPT5H_ENST00000598725.1_Missense_Mutation_p.T762I|SUPT5H_ENST00000402194.2_Missense_Mutation_p.T758I|SUPT5H_ENST00000359191.6_Missense_Mutation_p.T758I|SUPT5H_ENST00000432763.2_Missense_Mutation_p.T762I			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	762	9 X 7 AA approximate tandem repeats of G- S-[QR]-T-P-X-[YQ], motif CTR1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGCGGCATGACCTCGACCTAT	0.652000													20	62					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087396	92087396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92087396G>A	ENST00000298047.6	+	1	2135	c.2118G>A	c.(2116-2118)ctG>ctA	p.L706L	FAT3_ENST00000525166.1_Silent_p.L556L|FAT3_ENST00000409404.2_Silent_p.L706L|FAT3_ENST00000541502.1_Silent_p.L706L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	706					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGGGAAACTGAATCTGGAAG	0.403000										TCGA Ovarian(4;0.039)			34	114					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14746012	14746012	+	Silent	SNP	C	C	T	rs147231935		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14746012C>T	ENST00000284268.6	-	7	1212	c.882G>A	c.(880-882)acG>acA	p.T294T	ANKH_ENST00000535119.1_Silent_p.T96T|ANKH_ENST00000503939.1_5'UTR	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	294					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CACGGATTTCCGTCAACCAGC	0.522000													15	57					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52944946	52944946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52944946C>T	ENST00000295213.4	+	8	1440	c.1066C>T	c.(1066-1068)Cat>Tat	p.H356Y	SPATA18_ENST00000419395.2_Missense_Mutation_p.H324Y	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	356					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CTTCAAGATCCATGTGAGAAA	0.383000													27	120					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587530	179587530	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179587530T>C	ENST00000589042.1	-	76	22320	c.22096A>G	c.(22096-22098)Act>Gct	p.T7366A	TTN_ENST00000342992.6_Missense_Mutation_p.T6122A|TTN_ENST00000591111.1_Missense_Mutation_p.T7049A|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7049	Ig-like 55.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTCAGGAGTTGGCCGTAAT	0.418000													10	30					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477672	88477672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:88477672G>A	ENST00000267549.3	+	2	1039	c.481G>A	c.(481-483)Gat>Aat	p.D161N	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	161					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity	p.D161N(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TGAATATTGCGATGCCGAAAA	0.393000													42	146					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49569672	49569672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49569672C>T	ENST00000545947.1	+	6	2450	c.1728C>T	c.(1726-1728)ttC>ttT	p.F576F	DAG1_ENST00000308775.2_Silent_p.F576F|DAG1_ENST00000515359.2_Silent_p.F576F|DAG1_ENST00000538711.1_Silent_p.F576F|DAG1_ENST00000541308.1_Silent_p.F576F|DAG1_ENST00000539901.1_Silent_p.F576F	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	576	Peptidase S72.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		ACGAGTATTTCATGCATGCCA	0.597000													28	36					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460299	107460299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107460299G>A	ENST00000409382.3	-	2	745	c.135C>T	c.(133-135)ttC>ttT	p.F45F	ST6GAL2_ENST00000409087.3_Silent_p.F45F|ST6GAL2_ENST00000361686.4_Silent_p.F45F	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	45					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						TGGTCTCCAGGAAGGAGAGGG	0.632000													4	47					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142605697	142605697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142605697C>T	ENST00000265310.1	-	15	2521	c.2173G>A	c.(2173-2175)Gag>Aag	p.E725K		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	725	Involved in Ca(2+)-dependent inactivation (By similarity).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					TGGTAGACCTCCTCTCCATCC	0.557000													27	69					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125140818	125140818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125140818C>T	ENST00000362012.2	+	4	323	c.318C>T	c.(316-318)ttC>ttT	p.F106F	PTGS1_ENST00000223423.4_Silent_p.F106F|PTGS1_ENST00000540753.1_Silent_p.F81F|PTGS1_ENST00000373698.5_5'UTR	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	106					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATGCCACCTTCATCCGAGAGA	0.602000													15	54					0	0	1	0	0
COLEC12	81035	broad.mit.edu	37	18	357510	357510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:357510C>T	ENST00000400256.3	-	3	278	c.71G>A	c.(70-72)gGa>gAa	p.G24E		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	24					carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				ACATTGTGTTCCTTCCTGAAT	0.303000													17	59					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150840933	150840933	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150840933G>A	ENST00000370357.4	+	14	1961	c.1716G>A	c.(1714-1716)ctG>ctA	p.L572L		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	572						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					agcagccactgaagcaTAATG	0.522000													7	27					0	0	1	0	0
EHF	26298	broad.mit.edu	37	11	34668007	34668007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:34668007G>A	ENST00000257831.3	+	3	240	c.119G>A	c.(118-120)gGc>gAc	p.G40D	EHF_ENST00000530286.1_Missense_Mutation_p.G40D|EHF_ENST00000450654.2_Missense_Mutation_p.G40D|EHF_ENST00000527001.1_3'UTR|EHF_ENST00000531728.1_Missense_Mutation_p.G40D|EHF_ENST00000527935.1_Missense_Mutation_p.G40D|EHF_ENST00000531794.1_Missense_Mutation_p.G62D|EHF_ENST00000533754.1_Missense_Mutation_p.G40D	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	40	PNT.			G -> S (in Ref. 2; AAD30990/AAD30991).	cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TTTTTTGGAGGCCAGTGGCAT	0.527000													55	65					0	0	1	0	0
CLDN14	23562	broad.mit.edu	37	21	37833960	37833960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37833960G>A	ENST00000399137.1	-	3	900	c.34C>T	c.(34-36)Ctg>Ttg	p.L12L	AP000695.4_ENST00000428667.1_RNA|CLDN14_ENST00000342108.2_Silent_p.L12L|CLDN14_ENST00000399139.1_Silent_p.L12L|CLDN14_ENST00000399136.1_Silent_p.L12L|AP000695.6_ENST00000429588.1_RNA|CLDN14_ENST00000399135.1_Silent_p.L12L	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	12					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						AAGCTGAGCAGGAAGCCCAGA	0.697000													3	12					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34888154	34888154	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34888154C>A	ENST00000360581.1	+	8	1032	c.904C>A	c.(904-906)Ctt>Att	p.L302I	NPSR1_ENST00000359791.1_Missense_Mutation_p.L302I|NPSR1_ENST00000381539.3_Missense_Mutation_p.L302I|NPSR1_ENST00000381542.1_Missense_Mutation_p.L236I|NPSR1_ENST00000531252.1_Missense_Mutation_p.L291I	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	302						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	TTTCAACCTCCTTCCAGACAC	0.493000													23	283					2.21704e-12	2.22742e-12	1	1	0
PPP6R3	55291	broad.mit.edu	37	11	68343463	68343463	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68343463C>T	ENST00000393799.2	+	14	1764	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	PPP6R3_ENST00000393801.3_Silent_p.F499F|PPP6R3_ENST00000393800.2_Silent_p.F499F|PPP6R3_ENST00000524845.1_Silent_p.F499F|PPP6R3_ENST00000265636.5_Silent_p.F448F|PPP6R3_ENST00000265637.4_Silent_p.F499F|PPP6R3_ENST00000534534.1_Silent_p.F267F|PPP6R3_ENST00000524904.1_Silent_p.F499F|PPP6R3_ENST00000529710.1_Silent_p.F448F|PPP6R3_ENST00000527403.2_Silent_p.F499F			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	499					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						GGGAGACGTTCTGCACAAGCT	0.428000													46	104					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717018	142717018	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142717018A>G	ENST00000381779.4	-	2	2132	c.1907T>C	c.(1906-1908)tTt>tCt	p.F636S	SLITRK4_ENST00000356928.1_Missense_Mutation_p.F636S|SLITRK4_ENST00000338017.4_Missense_Mutation_p.F636S	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	636						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAAGGCAAAAAGCAACAAA	0.493000													40	34					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190423945	190423945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:190423945G>A	ENST00000367462.3	-	2	307	c.76C>T	c.(76-78)Cat>Tat	p.H26Y	FAM5C_ENST00000534846.1_5'UTR|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		26						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					ACCCAGCAATGAAGACTCAGT	0.522000													16	45					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73682332	73682332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:73682332C>T	ENST00000264448.6	+	9	7692	c.7581C>T	c.(7579-7581)tcC>tcT	p.S2527S	ALMS1_ENST00000409009.1_Silent_p.S2485S|ALMS1_ENST00000377715.1_Silent_p.S2527S	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2527					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GTGGATACTCCATTTCAGAAT	0.358000													16	131					0	0	1	0	0
DLX4	1748	broad.mit.edu	37	17	48050471	48050471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48050471C>T	ENST00000240306.3	+	2	613	c.318C>T	c.(316-318)tcC>tcT	p.S106S	DLX4_ENST00000503410.1_3'UTR|DLX4_ENST00000411890.2_Silent_p.S34S	NM_138281.2	NP_612138.1	Q92988	DLX4_HUMAN	distal-less homeobox 4	106					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(3)	10						CGGAACCCTCCGAGCGGCGCC	0.662000													25	51					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94114841	94114841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94114841C>T	ENST00000515393.1	-	19	2583	c.2584G>A	c.(2584-2586)Gaa>Aaa	p.E862K	MCTP1_ENST00000429576.2_Missense_Mutation_p.E555K|MCTP1_ENST00000505078.1_Missense_Mutation_p.E378K|MCTP1_ENST00000312216.8_Missense_Mutation_p.E641K|MCTP1_ENST00000514040.1_5'UTR	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	862					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TCTTCTTCTTCCTCGTCCTCT	0.418000													24	105					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7310207	7310207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7310207C>T	ENST00000537408.1	+	16	3224	c.2686C>T	c.(2686-2688)Cca>Tca	p.P896S	CLSTN3_ENST00000266546.6_Missense_Mutation_p.P884S|CLSTN3_ENST00000331148.5_3'UTR			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	884					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						CGGCGGGCCTCCAGGGGCCTC	0.642000													9	17					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38942416	38942416	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38942416C>T	ENST00000355481.4	+	12	1266	c.1135C>T	c.(1135-1137)Cag>Tag	p.Q379*	RYR1_ENST00000359596.3_Nonsense_Mutation_p.Q379*|RYR1_ENST00000360985.3_Nonsense_Mutation_p.Q379*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	379	MIR 5.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CATGCTGCACCAGGAGGGCCA	0.632000													18	65					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827076	96827076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96827076G>A	ENST00000371270.3	-	3	464	c.370C>T	c.(370-372)Cgg>Tgg	p.R124W	CYP2C8_ENST00000535898.1_Missense_Mutation_p.R22W|CYP2C8_ENST00000539050.1_Missense_Mutation_p.R38W	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	124					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GAGAAACGCCGGATCTCCTTC	0.488000													37	105					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124345	142124345	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142124345C>T	ENST00000390376.2	-	0	132																											TGGTTCATATCCTGGGCACAC	0.493000													47	108					0	0	1	0	0
METTL4	64863	broad.mit.edu	37	18	2566965	2566965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:2566965C>T	ENST00000319888.6	-	2	1049	c.251G>A	c.(250-252)cGa>cAa	p.R84Q	METTL4_ENST00000574538.1_Missense_Mutation_p.R84Q			Q8N3J2	METL4_HUMAN	methyltransferase like 4	84					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						AACAAATTTTCGTGTGAACAT	0.393000													31	96					0	0	1	0	0
ZYG11B	79699	broad.mit.edu	37	1	53236939	53236939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53236939C>T	ENST00000294353.6	+	3	589	c.444C>T	c.(442-444)ctC>ctT	p.L148L	ZYG11B_ENST00000443756.2_Silent_p.L148L|ZYG11B_ENST00000545132.1_Silent_p.L148L	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	148							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						CATTAACTCTCTCCCTCGAGG	0.473000													10	78					0	0	1	0	0
GFPT1	2673	broad.mit.edu	37	2	69556865	69556865	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69556865G>A	ENST00000357308.4	-	16	1726	c.1548C>T	c.(1546-1548)tcC>tcT	p.S516S	GFPT1_ENST00000361060.4_Silent_p.S498S	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	516	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						TTTCTTGCATGGAGATCCGAT	0.418000													6	90					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461789	11461789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11461789C>T	ENST00000279575.1	-	3	161	c.128G>A	c.(127-129)gGa>gAa	p.G43E	PRB4_ENST00000535904.1_Missense_Mutation_p.G43E|PRB4_ENST00000445719.2_Missense_Mutation_p.G43E	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	43	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						CTGGTTTCCTCCTTGTGGGCG	0.562000										HNSCC(22;0.051)			98	248					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75927692	75927692	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75927692C>T	ENST00000274364.6	+	15	1918	c.1621C>T	c.(1621-1623)Ctg>Ttg	p.L541L	IQGAP2_ENST00000396234.3_Silent_p.L94L|IQGAP2_ENST00000502745.1_Silent_p.L94L|IQGAP2_ENST00000379730.3_Silent_p.L100L	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	541					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGGGGTTACTCTGGTGGTTGA	0.338000													10	49					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39023355	39023355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39023355G>A	ENST00000355481.4	+	77	11354	c.11223G>A	c.(11221-11223)gaG>gaA	p.E3741E	RYR1_ENST00000359596.3_Silent_p.E3746E|RYR1_ENST00000360985.3_Silent_p.E3746E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3746					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AAGCTGAAGAGGAGGTTGAGG	0.597000													19	44					0	0	1	0	0
PSME2	5721	broad.mit.edu	37	14	24613611	24613611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24613611G>A	ENST00000216802.5	-	7	1066	c.427C>T	c.(427-429)Cag>Tag	p.Q143*	PSME2_ENST00000560410.1_Nonsense_Mutation_p.Q132*|PSME2_ENST00000471700.2_5'UTR	NM_002818.2	NP_002809.2	Q9UL46	PSME2_HUMAN	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	143					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex				endometrium(1)|lung(3)|prostate(2)	6				GBM - Glioblastoma multiforme(265;0.00839)		TTTCTTACCTGGATTGCTACC	0.438000													10	108					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33848614	33848614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:33848614C>T	ENST00000261326.5	+	15	2654	c.2633C>T	c.(2632-2634)cCt>cTt	p.P878L		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	878					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding	p.P878H(1)		breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	CATGATTTACCTGCATCTGAG	0.388000													5	89					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25043589	25043589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:25043589C>T	ENST00000216336.2	-	4	492	c.456G>A	c.(454-456)atG>atA	p.M152I		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	152	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		TTCCCCTCCTCATGCTGACCC	0.617000													40	106					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135447863	135447863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135447863G>A	ENST00000343036.2	+	7	977	c.929G>A	c.(928-930)gGg>gAg	p.G310E	C9orf171_ENST00000393216.2_Missense_Mutation_p.G274E	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	310										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						GTGCGCCAGGGGACCCTGCGG	0.597000													6	36					0	0	1	0	0
TMEM120B	144404	broad.mit.edu	37	12	122209422	122209422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:122209422C>T	ENST00000449592.2	+	8	747	c.646C>T	c.(646-648)Cgc>Tgc	p.R216C	TMEM120B_ENST00000540377.1_Intron	NM_001080825.2	NP_001074294.2	A0PK00	T120B_HUMAN	transmembrane protein 120B	216						integral to membrane		p.R216C(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(6)	11	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		TCAGAAGTTTCGCAACCAGTT	0.488000													29	88					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202735	56202735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56202735C>T	ENST00000361673.3	-	5	4897	c.4684G>A	c.(4684-4686)Ggc>Agc	p.G1562S	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1562							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TGAATTTGGCCTGTGGAGTTG	0.448000													27	96					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241835039	241835039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241835039C>T	ENST00000388934.4	-	1	534	c.376G>A	c.(376-378)Gag>Aag	p.E126K		NM_001085437.1	NP_001078906.1	Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	126										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		AAGGTATCCTCGGTGGTCCAC	0.622000													5	35					0	0	1	0	0
CLPS	1208	broad.mit.edu	37	6	35765005	35765005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35765005G>A	ENST00000259938.2	-	1	83	c.61C>T	c.(61-63)Ccc>Tcc	p.P21S		NM_001832.3	NP_001823.1	P04118	COL_HUMAN	colipase, pancreatic	21					lipid catabolic process|lipid digestion|retinoid metabolic process|steroid metabolic process	extracellular region				large_intestine(2)|lung(2)|prostate(1)	5						ATCCCCCGGGGGCCAGGAGCT	0.592000													24	135					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156924090	156924090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156924090G>A	ENST00000257527.4	-	14	1484	c.1406C>T	c.(1405-1407)gCt>gTt	p.A469V	ADAM19_ENST00000430702.2_Missense_Mutation_p.A202V|ADAM19_ENST00000517905.1_Missense_Mutation_p.A469V|ADAM19_ENST00000394020.1_Missense_Mutation_p.A471V	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	469	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTCCCAGGAGCCAACAGCTG	0.567000													6	28					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120702688	120702688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120702688C>T	ENST00000527524.2	+	7	926	c.639C>T	c.(637-639)gcC>gcT	p.A213A	GRIK4_ENST00000438375.2_Silent_p.A213A			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	213					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	ACAAGACCGCCACCATCATCA	0.642000													13	161					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53694273	53694273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53694273G>A	ENST00000288139.3	+	5	855	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	CACNA1D_ENST00000422281.2_Missense_Mutation_p.R246Q|CACNA1D_ENST00000350061.5_Missense_Mutation_p.R246Q	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	246					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CGAGTGTTGCGACCACTTCGA	0.478000													15	76					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60506800	60506800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60506800G>A	ENST00000371201.3	-	4	453	c.346C>T	c.(346-348)Ccc>Tcc	p.P116S	C1orf87_ENST00000450089.2_Intron	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	116							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GCTTGACTGGGAATCTTAACA	0.458000													14	23					0	0	1	0	0
EPYC	1833	broad.mit.edu	37	12	91371958	91371958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91371958C>T	ENST00000261172.3	-	3	339	c.247G>A	c.(247-249)Gaa>Aaa	p.E83K		NM_004950.4	NP_004941.2	Q99645	EPYC_HUMAN	epiphycan	83	Poly-Glu.				female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding	p.E83K(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|skin(2)	18						TCCTCCTCTTCCTCTTCCTGG	0.507000											OREG0022019	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	102					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1428303	1428303	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1428303G>A	ENST00000381524.3	+	13	1320	c.1134G>A	c.(1132-1134)tgG>tgA	p.W378*	CSF2RA_ENST00000355805.2_3'UTR|CSF2RA_ENST00000501036.2_Nonsense_Mutation_p.W245*|CSF2RA_ENST00000417535.2_Nonsense_Mutation_p.W412*|CSF2RA_ENST00000432318.2_Nonsense_Mutation_p.W378*|CSF2RA_ENST00000361536.3_3'UTR|CSF2RA_ENST00000381500.1_3'UTR|CSF2RA_ENST00000498153.1_3'UTR|CSF2RA_ENST00000381529.3_Nonsense_Mutation_p.W378*|CSF2RA_ENST00000355432.3_Missense_Mutation_p.G319R			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	378						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AGATCATCTGGGAGGAATTCA	0.512000													39	76					0	0	1	0	0
OR2A7	401427	broad.mit.edu	37	7	143955944	143955944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143955944C>T	ENST00000493325.1	-	1	871	c.778G>A	c.(778-780)Gga>Aga	p.G260R	RP4-798C17.6_ENST00000463561.1_RNA|RP4-798C17.6_ENST00000489488.1_RNA|RP4-798C17.6_ENST00000461843.1_RNA|ARHGEF35_ENST00000543357.1_Intron|RP4-798C17.6_ENST00000478806.1_RNA|RP4-545C24.1_ENST00000460955.1_RNA|RP4-798C17.6_ENST00000487102.1_RNA|RP4-798C17.6_ENST00000476560.1_RNA	NM_001005328.1	NP_001005328.1	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A, member 7	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	6	Melanoma(164;0.14)					TATCTGGGTCCAACATACATG	0.463000													20	176					0	0	1	0	0
WAPAL	23063	broad.mit.edu	37	10	88211809	88211809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88211809G>A	ENST00000298767.5	-	15	3501	c.3029C>T	c.(3028-3030)tCt>tTt	p.S1010F	WAPAL_ENST00000372075.1_Intron|WAPAL_ENST00000263070.7_Intron	NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	1010	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						AGAATCAAAAGAGCACGATGT	0.428000													14	133					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57425826	57425826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57425826C>T	ENST00000371237.4	-	2	182	c.116G>A	c.(115-117)gGg>gAg	p.G39E	C8B_ENST00000535057.1_5'UTR|C8B_ENST00000543257.1_5'UTR|C8B_ENST00000494324.1_5'UTR	NM_000066.2	NP_000057.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	39					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGCATTTGACCCAAAGGAATG	0.428000													8	94					0	0	1	0	0
LOC653786	653786	broad.mit.edu	37	16	22588008	22588008	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:22588008C>T	ENST00000550753.1	+	0	2483					NR_003676.2																						TGGTGAGTGGCCTGAGCACAT	0.547000													8	51					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72351362	72351362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72351362G>A	ENST00000389916.4	+	20	3046	c.2908G>A	c.(2908-2910)Ggt>Agt	p.G970S		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	970					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CCCCAACCCAGGTGGTGGTTC	0.667000													16	77					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17668880	17668880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17668880G>A	ENST00000375448.4	+	8	944	c.918G>A	c.(916-918)caG>caA	p.Q306Q	AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	306					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	AGCCCCCGCAGGAGGTGTACG	0.642000													15	43					0	0	1	0	0
CDCA7	83879	broad.mit.edu	37	2	174224139	174224139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:174224139G>A	ENST00000306721.3	+	3	407	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K	CDCA7_ENST00000410101.3_Missense_Mutation_p.E58K|CDCA7_ENST00000392567.2_Intron|CDCA7_ENST00000347703.3_Intron|CDCA7_ENST00000410019.3_Intron	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	0					regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.E102K(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			TGTCACTAACGAACTGGCCGG	0.423000													28	73					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947100	57947100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57947100C>T	ENST00000335397.3	+	3	500	c.184C>T	c.(184-186)Ctt>Ttt	p.L62F		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				AATGTATTTCCTTCTGAGTCA	0.468000													38	178					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44845619	44845619	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44845619C>T	ENST00000372262.3	-	4	1084	c.684G>A	c.(682-684)acG>acA	p.T228T	CDH22_ENST00000537909.1_Silent_p.T228T|CDH22_ENST00000474438.1_5'UTR	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	228	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CAGGCACAGCCGTCCGGATTA	0.652000													23	76					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70541868	70541868	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70541868C>T	ENST00000310961.5	+	24	4517	c.4099C>T	c.(4099-4101)Cag>Tag	p.Q1367*	LRRC7_ENST00000035383.5_Nonsense_Mutation_p.Q1409*|LRRC7_ENST00000415775.2_Nonsense_Mutation_p.Q693*			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1409						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCAGCAATTTCAGTCACCATT	0.522000													30	60					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103230142	103230142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103230142C>T	ENST00000424685.2	-	28	4205	c.4046G>A	c.(4045-4047)gGa>gAa	p.G1349E	RELN_ENST00000343529.5_Missense_Mutation_p.G1349E|RELN_ENST00000428762.1_Missense_Mutation_p.G1349E			P78509	RELN_HUMAN	reelin	1349					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.G1349E(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCTGGAGTTTCCTTCGCATCC	0.478000													39	109					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20249284	20249284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20249284C>T	ENST00000315957.4	+	1	884	c.803C>T	c.(802-804)tCc>tTc	p.S268F		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S268F(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GACTCATTTTCCCTAGATAAA	0.418000													38	113					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96555182	96555182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:96555182G>A	ENST00000376747.3	-	21	2498	c.2428C>T	c.(2428-2430)Ctt>Ttt	p.L810F		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	810					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						AGTTGCCCAAGAAAGCTTCTC	0.318000													13	124					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43205702	43205702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43205702G>A	ENST00000255226.6	+	3	1021	c.205G>A	c.(205-207)Gaa>Aaa	p.E69K	SLC14A2_ENST00000586448.1_Missense_Mutation_p.E69K	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	69						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AAAGCTCAATGAAAGGAGTAA	0.498000													14	46					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39085814	39085814	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:39085814G>A	ENST00000295373.6	-	6	1702	c.1576C>T	c.(1576-1578)Cga>Tga	p.R526*	DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	526							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TGTTTCATTCGGAACTGCTTG	0.413000													86	198					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176721426	176721426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176721426C>T	ENST00000439151.2	+	23	7102	c.7057C>T	c.(7057-7059)Cct>Tct	p.P2353S	NSD1_ENST00000347982.4_Missense_Mutation_p.P2084S|NSD1_ENST00000361032.4_Missense_Mutation_p.P2250S|NSD1_ENST00000354179.4_Missense_Mutation_p.P2084S	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2353	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACTGGAAAGACCTCTGGGGAC	0.592000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			13	45					0	0	1	0	0
MS4A3	932	broad.mit.edu	37	11	59828646	59828646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59828646G>A	ENST00000278865.3	+	2	86	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	MS4A3_ENST00000526199.1_3'UTR|MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000534744.1_Missense_Mutation_p.E5K|MS4A3_ENST00000358152.2_Missense_Mutation_p.E5K	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	5						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				GGCCTCCCACGAAGTTGATAA	0.483000													25	67					0	0	1	0	0
EPS8L2	64787	broad.mit.edu	37	11	723306	723306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:723306C>T	ENST00000533256.1	+	16	1782	c.1407C>T	c.(1405-1407)acC>acT	p.T469T	EPS8L2_ENST00000526198.1_Silent_p.T485T|EPS8L2_ENST00000318562.8_Silent_p.T469T|EPS8L2_ENST00000530636.1_Silent_p.T469T|AP006621.9_ENST00000527021.2_RNA			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	469						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGAGCCCACCCCCCCGGGGG	0.582000											OREG0020659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	71					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52927008	52927008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:52927008C>T	ENST00000295213.4	+	3	628	c.254C>T	c.(253-255)tCc>tTc	p.S85F	SPATA18_ENST00000506829.1_Intron|SPATA18_ENST00000419395.2_Missense_Mutation_p.S85F	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	85					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CTGGAGGCTTCCTTTACTGCT	0.478000													29	56					0	0	1	0	0
ITGBL1	9358	broad.mit.edu	37	13	102250508	102250508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:102250508G>A	ENST00000376180.3	+	7	1093	c.874G>A	c.(874-876)Gga>Aga	p.G292R	ITGBL1_ENST00000545560.2_Missense_Mutation_p.G151R|ITGBL1_ENST00000376162.3_Missense_Mutation_p.G199R	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	292	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity	p.G292*(1)		breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGAAGGTCATGGACAGTGTAA	0.428000													26	81					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13794063	13794063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13794063G>A	ENST00000265104.4	-	48	8096	c.7992C>T	c.(7990-7992)atC>atT	p.I2664I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2664	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCCACTCATTGATTATTGGCA	0.323000									Kartagener syndrome				31	58					0	0	1	0	0
KIFC1	3833	broad.mit.edu	37	6	33373143	33373143	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:33373143C>T	ENST00000428849.2	+	7	1721	c.1271C>T	c.(1270-1272)cCt>cTt	p.P424L		NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	424	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						GAGGGTGGGCCTGGGGGAGAC	0.602000													21	64					0	0	1	0	0
ERRFI1	54206	broad.mit.edu	37	1	8073809	8073809	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8073809G>T	ENST00000377482.5	-	4	1073	c.850C>A	c.(850-852)Ccc>Acc	p.P284T	ERRFI1_ENST00000474874.1_Intron|ERRFI1_ENST00000469499.1_3'UTR|ERRFI1_ENST00000467067.1_3'UTR	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	284					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		ACTCTGGGGGGAACCTCAGGT	0.483000													49	106					2.81731e-22	2.83499e-22	1	1	0
ADAM32	203102	broad.mit.edu	37	8	39114774	39114774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39114774C>T	ENST00000379907.4	+	19	2201	c.2074C>T	c.(2074-2076)Cct>Tct	p.P692S	ADAM32_ENST00000437682.2_Missense_Mutation_p.P593S|ADAM32_ENST00000519315.1_Missense_Mutation_p.P586S	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	692					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.P691S(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CATTGCTCTTCCTATTCTCAT	0.378000													25	75					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40367848	40367848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40367848G>A	ENST00000221347.6	-	29	13119	c.13112C>T	c.(13111-13113)tCc>tTc	p.S4371F		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4371	TIL 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGGTGCAGGGGACGGACAGCT	0.622000													28	46					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994117	140994117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140994117C>T	ENST00000285879.4	+	4	1213	c.927C>T	c.(925-927)tcC>tcT	p.S309S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	309				SSS -> PSF (in Ref. 2; AAC24227).			protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTGAGCTCCTCCTCCTCCT	0.478000										HNSCC(15;0.026)			135	126					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55762066	55762066	+	Silent	SNP	G	G	A	rs139328258		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55762066G>A	ENST00000278409.1	-	1	35	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					CCAATAGGACGAACTCAGTCA	0.338000													27	84					0	0	1	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154987313	154987313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154987313C>T	ENST00000368426.3	+	3	314	c.177C>T	c.(175-177)ttC>ttT	p.F59F	ZBTB7B_ENST00000487542.1_3'UTR|ZBTB7B_ENST00000535420.1_Silent_p.F59F|ZBTB7B_ENST00000417934.2_Silent_p.F93F|ZBTB7B_ENST00000292176.2_Silent_p.F59F	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	59	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCCACTACTTCAAGAAGCTTT	0.652000													10	122					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38395848	38395848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:38395848C>T	ENST00000377698.3	+	2	256	c.103C>T	c.(103-105)Ccc>Tcc	p.P35S		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	35					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CCCAGACATCCCCTACAACCA	0.612000													21	55					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111343190	111343190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111343190C>T	ENST00000352690.4	+	10	1500	c.1260C>T	c.(1258-1260)tcC>tcT	p.S420S	CD96_ENST00000283285.5_Silent_p.S436S	NM_005816.4	NP_005807.1	P40200	TACT_HUMAN	CD96 molecule	436	Pro/Ser/Thr-rich.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(4)|liver(2)|lung(14)|skin(5)	35						CCAGCAATTCCAGTATGACTA	0.393000									Opitz Trigonocephaly syndrome				25	87					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141128790	141128790	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141128790C>T	ENST00000389484.3	-	70	11804	c.10833G>A	c.(10831-10833)ttG>ttA	p.L3611L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3611	LDL-receptor class A 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTACATTTCAAAGATGCTG	0.303000										TSP Lung(27;0.18)			15	33					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77407037	77407037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77407037G>A	ENST00000560626.2	-	7	5177	c.4702C>T	c.(4702-4704)Ccc>Tcc	p.P1568S	PEAK1_ENST00000312493.4_Missense_Mutation_p.P1568S			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1568	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										AGGATCTCGGGGTCCACCAGA	0.537000													43	149					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101624234	101624234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101624234C>T	ENST00000311812.2	-	7	755	c.605G>A	c.(604-606)cGa>cAa	p.R202Q	SNX31_ENST00000428383.2_Missense_Mutation_p.R103Q	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	202					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TTACCACTTTCGGAGTCCAAC	0.468000													16	75					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110474031	110474031	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110474031G>A	ENST00000378402.5	+	48	7381	c.7277G>A	c.(7276-7278)gGa>gAa	p.G2426E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2426					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTCTCCAAGGAAAGTTTGGA	0.368000										HNSCC(38;0.096)			5	21					0	0	1	0	0
MPZ	4359	broad.mit.edu	37	1	161276165	161276165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161276165G>A	ENST00000533357.1	-	4	604	c.538C>T	c.(538-540)Cgg>Tgg	p.R180W	MPZ_ENST00000336559.4_Missense_Mutation_p.R180W|MPZ_ENST00000491222.2_5'UTR|MPZ_ENST00000360451.6_Missense_Mutation_p.R190W|MPZ_ENST00000526189.1_5'UTR	NM_000530.6	NP_000521.2	P25189	MYP0_HUMAN	myelin protein zero	180					synaptic transmission	integral to plasma membrane	structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	10	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAGCAGTACCGAACCACGTAG	0.647000													42	85					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234112995	234112995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234112995G>A	ENST00000359570.5	+	28	3163	c.3163G>A	c.(3163-3165)Gag>Aag	p.1055_1055insK	INPP5D_ENST00000455936.2_Missense_Mutation_p.819_819insK|INPP5D_ENST00000450745.1_Missense_Mutation_p.819_819insK			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	0	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CAAAGCCCAGGAGGCTGATCG	0.711000													17	38					0	0	1	0	0
SLC1A1	6505	broad.mit.edu	37	9	4544603	4544603	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:4544603A>G	ENST00000262352.3	+	2	364	c.128A>G	c.(127-129)aAc>aGc	p.N43S		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	43					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	GAACACAGCAACCTCTCAACT	0.388000													23	118					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187023	123187023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123187023G>A	ENST00000328880.5	-	1	867	c.808C>T	c.(808-810)Cgc>Tgc	p.R270C	RP11-324E6.6_ENST00000543611.1_lincRNA|HCAR1_ENST00000356987.2_Intron	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	270					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	TCCACCGAGCGGTACACTTCA	0.552000													6	42					0	0	1	0	0
FAM188B	84182	broad.mit.edu	37	7	30830929	30830929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:30830929C>T	ENST00000265299.6	+	5	889	c.812C>T	c.(811-813)tCc>tTc	p.S271F	INMT-FAM188B_ENST00000458257.1_3'UTR	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	271										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TCCAGGACCTCCCTGGGTCAG	0.607000													39	74					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71101166	71101166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71101166G>A	ENST00000288168.10	-	15	2166	c.2153C>T	c.(2152-2154)cCt>cTt	p.P718L	HYDIN_ENST00000538248.1_Intron|HYDIN_ENST00000321489.5_Intron|HYDIN_ENST00000448089.2_Intron|HYDIN_ENST00000448691.1_Intron|HYDIN_ENST00000393550.2_Intron|HYDIN_ENST00000393567.2_Intron|HYDIN_ENST00000541601.1_Intron			Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	0										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GGGCGACTCAGGAGAAGAGCA	0.587000													12	14					0	0	1	0	0
PRIMA1	145270	broad.mit.edu	37	14	94187839	94187839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94187839C>T	ENST00000393140.1	-	5	515	c.413G>A	c.(412-414)aGt>aAt	p.S138N	PRIMA1_ENST00000316227.3_3'UTR|PRIMA1_ENST00000393143.1_Missense_Mutation_p.S138N	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	138					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		CTGCGAAGCACTCATGGGATA	0.582000													11	54					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41582036	41582036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41582036C>T	ENST00000396942.1	-	7	732	c.649G>A	c.(649-651)Gag>Aag	p.E217K	ANK1_ENST00000289734.7_Missense_Mutation_p.E217K|ANK1_ENST00000347528.4_Missense_Mutation_p.E217K|ANK1_ENST00000379758.2_Missense_Mutation_p.E217K|ANK1_ENST00000352337.4_Missense_Mutation_p.E217K|ANK1_ENST00000265709.8_Missense_Mutation_p.E250K|ANK1_ENST00000396945.1_Missense_Mutation_p.E217K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	217	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TTGAGGTTCTCGTAGTGAGCC	0.567000													3	5					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41008108	41008108	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41008108G>A	ENST00000352632.3	+	9	1057	c.971G>A	c.(970-972)tGg>tAg	p.W324*	SPTBN4_ENST00000598249.1_Nonsense_Mutation_p.W324*|SPTBN4_ENST00000595535.1_Nonsense_Mutation_p.W324*|SPTBN4_ENST00000344104.3_Nonsense_Mutation_p.W324*|SPTBN4_ENST00000338932.3_Nonsense_Mutation_p.W324*			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	324					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGCTGGCCTGGATCCACCGC	0.582000													30	76					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152327273	152327273	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152327273A>T	ENST00000388718.5	-	3	3061	c.2989T>A	c.(2989-2991)Tct>Act	p.S997T	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	997	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATAATTAGACTGACTTGAT	0.488000													160	390					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61391751	61391751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61391751C>T	ENST00000424789.2	+	8	944	c.940C>T	c.(940-942)Cgc>Tgc	p.R314C	TANC2_ENST00000389520.4_Missense_Mutation_p.R314C|AC037445.1_ENST00000581421.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	314							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CCTTTCAGTTCGCTTTGCACC	0.438000													24	40					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613867	179613867	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179613867T>A	ENST00000360870.5	-	46	13482	c.13260A>T	c.(13258-13260)ccA>ccT	p.P4420P	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	548	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGAATATTTGGTAAATAGT	0.343000													23	62					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21605853	21605853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21605853G>A	ENST00000357071.4	-	1	189	c.75C>T	c.(73-75)tcC>tcT	p.S25S	ECE1_ENST00000436918.2_Intron|ECE1_ENST00000264205.6_Intron|ECE1_ENST00000374893.6_Intron|ECE1_ENST00000415912.2_Intron	NM_001113347.1	NP_001106818.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	0					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		GGAGGGGCGGGGAAGACGTGA	0.701000													23	47					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	318966	318966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:318966G>A	ENST00000428720.1	-	3	930	c.187C>T	c.(187-189)Ccc>Tcc	p.P63S	SLC6A12_ENST00000359674.4_Missense_Mutation_p.P63S|SLC6A12_ENST00000536824.1_Missense_Mutation_p.P63S|SLC6A12_ENST00000424061.2_Missense_Mutation_p.P63S|SLC6A12_ENST00000397296.2_Missense_Mutation_p.P63S	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	63					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			CAGAGATAGGGAAACCTCCAG	0.577000													33	138					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	595460	595460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:595460C>T	ENST00000381578.1	+	3	1076	c.385C>T	c.(385-387)Ctg>Ttg	p.L129L	SHOX_ENST00000554971.1_Silent_p.L129L|SHOX_ENST00000334060.3_Silent_p.L129L|SHOX_ENST00000381575.1_Silent_p.L129L	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	129					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCTGGAGCAGCTGAACGAGCT	0.637000													16	23					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74973960	74973960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74973960C>T	ENST00000261978.4	-	26	4215	c.3829G>A	c.(3829-3831)Gaa>Aaa	p.E1277K	LTBP2_ENST00000556690.1_Intron	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1277	Cys-rich.|EGF-like 14; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGGCTGTTTTCACACTTCCAG	0.592000													27	87					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107430068	107430068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107430068G>A	ENST00000340010.5	-	6	820	c.636C>T	c.(634-636)ggC>ggT	p.G212G	SLC26A3_ENST00000422236.2_Silent_p.G177G	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	212					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						CAGTAGTGAAGCCACTGATGA	0.423000													7	37					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228210584	228210584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228210584C>T	ENST00000284523.1	+	2	366	c.288C>T	c.(286-288)gcC>gcT	p.A96A	WNT3A_ENST00000366753.2_Silent_p.A96A	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	96					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				ACAGCCTGGCCATCTTCGGGC	0.652000													28	40					0	0	1	0	0
C10orf118	55088	broad.mit.edu	37	10	115889665	115889665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115889665G>A	ENST00000369287.3	-	13	2433	c.2167C>T	c.(2167-2169)Cgt>Tgt	p.R723C	C10orf118_ENST00000543782.1_Missense_Mutation_p.R321C	NM_018017.2	NP_060487.2	Q7Z3E2	CJ118_HUMAN	chromosome 10 open reading frame 118	723	Ser-rich.									NS(1)|autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(2)	24		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		GAACTAGAACGACTTCCCATG	0.368000													38	92					0	0	1	0	0
RIOK3	8780	broad.mit.edu	37	18	21044179	21044179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21044179C>T	ENST00000339486.3	+	4	952	c.335C>T	c.(334-336)tCc>tTc	p.S112F	RIOK3_ENST00000581585.1_Missense_Mutation_p.S96F|RIOK3_ENST00000577501.1_Missense_Mutation_p.S112F	NM_003831.3	NP_003822.2	O14730	RIOK3_HUMAN	RIO kinase 3	112					chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(2)	10	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GTTTCCATTTCCTTTGAAAAT	0.373000													9	42					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117639386	117639386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117639386C>T	ENST00000368508.3	-	37	6168	c.5970G>A	c.(5968-5970)gaG>gaA	p.E1990E	ROS1_ENST00000368507.3_Silent_p.E1984E|GOPC_ENST00000467125.1_5'UTR	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1990	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ATTCAATCTTCTCCTGGTCTG	0.393000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								24	29					0	0	1	0	0
NUGGC	389643	broad.mit.edu	37	8	27925193	27925193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27925193C>T	ENST00000413272.2	-	6	691	c.549G>A	c.(547-549)gaG>gaA	p.E183E	NUGGC_ENST00000341513.6_Silent_p.E183E	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		ACGCATCTGCCTCTTCTCTGC	0.537000													9	34					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43274922	43274922	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43274922G>A	ENST00000422911.1	-	5	503	c.402C>T	c.(400-402)ttC>ttT	p.F134F	PRDM15_ENST00000269844.3_Silent_p.F463F|PRDM15_ENST00000398548.1_Silent_p.F134F|PRDM15_ENST00000447207.2_Silent_p.F97F|PRDM15_ENST00000538201.1_Silent_p.F97F			P57071	PRD15_HUMAN	PR domain containing 15	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CGTCCTTCTGGAACACCTGAA	0.612000													9	29					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51133251	51133251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51133251C>T	ENST00000338916.4	-	3	1485	c.852G>A	c.(850-852)cgG>cgA	p.R284R	SYT3_ENST00000600079.1_Silent_p.R284R|SYT3_ENST00000544769.1_Silent_p.R284R|SYT3_ENST00000593901.1_Silent_p.R284R	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	284						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CCCCACCGCTCCGCCGGCCAC	0.662000													26	69					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58563491	58563491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:58563491G>A	ENST00000267485.7	-	5	2234	c.2040C>T	c.(2038-2040)acC>acT	p.T680T		NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	680						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						GCACCTGGTAGGTAGCTCCCT	0.527000													19	34					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35857148	35857148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35857148C>T	ENST00000303115.3	+	1	198	c.69C>T	c.(67-69)ggC>ggT	p.G23G	IL7R_ENST00000511031.1_Intron|IL7R_ENST00000506850.1_Silent_p.G23G|IL7R_ENST00000343305.4_Silent_p.G23G|IL7R_ENST00000511982.1_Silent_p.G23G	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	23					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GAGAAAGTGGCTATGCTCAAA	0.383000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						80	166					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11505674	11505674	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11505674G>A	ENST00000379237.1	-	15	1647	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	USP6NL_ENST00000277575.5_Missense_Mutation_p.P435L	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	418						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						CCTGCTCTGGGGGTGCGGGGA	0.652000													16	38					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160917803	160917803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160917803G>A	ENST00000368029.3	-	7	798	c.741C>T	c.(739-741)ttC>ttT	p.F247F	ITLN2_ENST00000494442.1_5'UTR|RP11-544M22.1_ENST00000356006.3_RNA	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	247	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GGAACTGAACGAATCCTGCAA	0.468000													23	76					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187479	123187479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123187479G>A	ENST00000328880.5	-	1	411	c.352C>T	c.(352-354)Ctc>Ttc	p.L118F	RP11-324E6.6_ENST00000543611.1_lincRNA|HCAR1_ENST00000356987.2_Intron	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	118					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	ACCACCGTGAGGAAGATGATG	0.562000													21	79					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56243490	56243490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56243490G>A	ENST00000332836.2	-	2	1734	c.1707C>T	c.(1705-1707)ttC>ttT	p.F569F		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	569						cytoplasm	ATP binding	p.F569F(1)		NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CAATATAAATGAAAACTTCTT	0.343000													18	45					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85449568	85449568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:85449568G>A	ENST00000393217.2	+	8	1058	c.997G>A	c.(997-999)Gaa>Aaa	p.E333K		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	333	Glu-rich.							p.E333*(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		acaaaaggaggaagaaaatcg	0.333000													12	13					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73905028	73905028	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:73905028C>T	ENST00000342056.2	+	15	3145	c.2747C>T	c.(2746-2748)gCc>gTc	p.A916V	KCNQ5_ENST00000355635.3_Missense_Mutation_p.A898V|KCNQ5_ENST00000355194.4_Missense_Mutation_p.A897V|KCNQ5_ENST00000370398.1_Missense_Mutation_p.A897V|KCNQ5_ENST00000414165.2_Missense_Mutation_p.A787V|KCNQ5_ENST00000403813.2_Missense_Mutation_p.A888V|KCNQ5_ENST00000402622.2_Missense_Mutation_p.A907V	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	897					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AGGGAAGCTGCCTTTGCATCA	0.498000													11	144					0	0	1	0	0
SH2D7	646892	broad.mit.edu	37	15	78393515	78393515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78393515G>A	ENST00000328828.5	+	5	920	c.920G>A	c.(919-921)gGt>gAt	p.G307D	SH2D7_ENST00000409568.2_Missense_Mutation_p.G171D	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	307										endometrium(2)|kidney(2)|lung(3)	7						CCAGACCAGGGTCCCACAGAG	0.607000													5	23					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50217819	50217819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50217819G>A	ENST00000338821.5	-	28	3339	c.3075C>T	c.(3073-3075)ctC>ctT	p.L1025L	ATP9A_ENST00000311637.5_Silent_p.L889L|ATP9A_ENST00000402822.1_Silent_p.L904L	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	1025					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CATAGAGGGGGAGGCAGCTGA	0.567000													18	35					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52131211	52131211	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52131211G>A	ENST00000222107.4	-	5	1011	c.873C>T	c.(871-873)acC>acT	p.T291T	SIGLEC5_ENST00000599649.1_Silent_p.T291T|SIGLEC5_ENST00000429354.3_Silent_p.T291T|SIGLEC5_ENST00000570106.2_Silent_p.T291T|SIGLEC5_ENST00000534261.2_Silent_p.T291T			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	291	Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TGGAGATGGGGGTGGCGTTCA	0.642000													43	112					0	0	1	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070619	32070619	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32070619C>T	ENST00000566806.1	-	0	499																											TGCAAGGCTTCTGGATACACC	0.537000													11	74					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35802490	35802490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35802490G>A	ENST00000400441.3	-	3	286	c.287C>T	c.(286-288)cCc>cTc	p.P96L	MROH8_ENST00000217333.8_Missense_Mutation_p.P11L|MROH8_ENST00000441008.2_Missense_Mutation_p.P82L					maestro heat-like repeat family member 8																		ATAGGCACAGGGGATCACTAC	0.393000													8	27					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70501251	70501251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70501251C>T	ENST00000260128.4	+	8	1326	c.609C>T	c.(607-609)ttC>ttT	p.F203F	SULF1_ENST00000419716.3_Silent_p.F203F|SULF1_ENST00000458141.2_Silent_p.F203F|SULF1_ENST00000402687.4_Silent_p.F203F	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	203					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTAATTACTTCAAAATGTCTA	0.433000													20	71					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111037	7111037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7111037G>A	ENST00000306904.5	+	1	873	c.686G>A	c.(685-687)cGg>cAg	p.R229Q		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	229	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding	p.R229Q(1)		NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CGCGAACCCCGGGGTTTTGCC	0.701000													13	19					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57069596	57069596	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57069596G>A	ENST00000532437.1	-	7	5097	c.4786C>T	c.(4786-4788)Ctg>Ttg	p.L1596L	TNKS1BP1_ENST00000358252.3_Silent_p.L1596L			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1596	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GCCTCCGACAGGCCCAAGGTA	0.597000													35	86					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580800	140580800	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140580800C>T	ENST00000354757.3	+	1	1453	c.1453C>T	c.(1453-1455)Cag>Tag	p.Q485*	PCDHB11_ENST00000536699.1_Nonsense_Mutation_p.Q120*	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		485	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCAACGCCCAGGTCAACTA	0.632000													75	202					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77377329	77377329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77377329C>T	ENST00000451710.3	-	26	4495	c.4258G>A	c.(4258-4260)Gca>Aca	p.A1420T	TRPM6_ENST00000376864.4_Missense_Mutation_p.A1420T|TRPM6_ENST00000361255.3_Missense_Mutation_p.A1415T|TRPM6_ENST00000360774.1_Missense_Mutation_p.A1420T|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Missense_Mutation_p.A1415T			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1420					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						ACTTGCTCTGCCTTGTCTTGT	0.512000													27	63					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028767	37028767	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37028767C>T	ENST00000358047.3	+	1	2336	c.2284C>T	c.(2284-2286)Ctc>Ttc	p.L762F		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	762										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CGTATCTCATCTCCGCCCGGA	0.632000													41	27					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45479473	45479473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45479473G>A	ENST00000334940.6	+	5	446	c.312G>A	c.(310-312)aaG>aaA	p.K104K	RASSF4_ENST00000374417.2_Intron|RASSF4_ENST00000340258.4_Silent_p.K95K|RASSF4_ENST00000472561.1_Intron			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	95					cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						TTTTCAGAAAGGAGCCATCGC	0.602000													3	7					0	0	1	0	0
TM7SF2	7108	broad.mit.edu	37	11	64882811	64882811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64882811G>A	ENST00000279263.7	+	8	1080	c.918G>A	c.(916-918)ggG>ggA	p.G306G	TM7SF2_ENST00000345348.5_Intron|TM7SF2_ENST00000540748.1_Silent_p.G190G	NM_003273.2	NP_003264.2	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	306					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCTTCCGTGGGGCGAATTCCC	0.572000													46	115					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2020477	2020477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2020477G>A	ENST00000262113.4	+	9	987	c.846G>A	c.(844-846)gaG>gaA	p.E282E	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	282	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AGTTTTTGGAGAAGTTTGGGG	0.597000													16	48					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42050647	42050647	+	Silent	SNP	G	G	A	rs141964626		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42050647G>A	ENST00000220809.4	-	2	313	c.57C>T	c.(55-57)ttC>ttT	p.F19F	PLAT_ENST00000524009.1_Silent_p.F19F|PLAT_ENST00000519510.1_Silent_p.F19F|PLAT_ENST00000429710.2_Silent_p.F19F|PLAT_ENST00000429089.2_Silent_p.F19F|PLAT_ENST00000352041.3_Silent_p.F19F|PLAT_ENST00000270189.6_Silent_p.F19F	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	19					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGGGCGAAACGAAGACTGCTC	0.567000													25	57					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7696348	7696348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7696348G>A	ENST00000572933.1	+	48	8854	c.7394G>A	c.(7393-7395)cGa>cAa	p.R2465Q	DNAH2_ENST00000389173.2_Missense_Mutation_p.R2465Q			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2465	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTTGAGAAGCGAACCAAGGGT	0.512000													36	56					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39927939	39927939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39927939C>T	ENST00000393931.3	-	2	286	c.168G>A	c.(166-168)aaG>aaA	p.K56K	JUP_ENST00000310706.5_Silent_p.K56K|JUP_ENST00000540235.1_Silent_p.K56K|JUP_ENST00000393930.1_Silent_p.K56K	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	56					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		TGGTGGTTTTCTTGAGCGTGT	0.637000													33	33					0	0	1	0	0
IFITM5	387733	broad.mit.edu	37	11	298534	298534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:298534G>A	ENST00000382614.2	-	2	401	c.366C>T	c.(364-366)ttC>ttT	p.F122F		NM_001025295.1	NP_001020466.1	A6NNB3	IFM5_HUMAN	interferon induced transmembrane protein 5	122					multicellular organismal development|regulation of bone mineralization|response to biotic stimulus	integral to membrane|plasma membrane				lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.73e-28)|Epithelial(43;3.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.14e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0328)|LUSC - Lung squamous cell carcinoma(625;0.122)		ACTTGGTGCTGAAGAAGGCGG	0.672000													13	23					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49227424	49227424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:49227424C>T	ENST00000327979.2	-	6	791	c.380G>A	c.(379-381)aGg>aAg	p.R127K	FAM65C_ENST00000045083.2_Missense_Mutation_p.R127K|FAM65C_ENST00000535356.1_Missense_Mutation_p.R131K			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	127										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCGAATGTGCCTTTCCACACA	0.597000													33	86					0	0	1	0	0
ART5	116969	broad.mit.edu	37	11	3661201	3661201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3661201C>T	ENST00000397068.3	-	2	850	c.458G>A	c.(457-459)gGa>gAa	p.G153E	ART5_ENST00000397067.3_Missense_Mutation_p.G153E|ART5_ENST00000359918.4_Missense_Mutation_p.G153E	NM_053017.3	NP_443750.2	Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5	153						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)|ovary(1)	11		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCCCCAGGTCCCCTGCTGCA	0.637000													26	38					0	0	1	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23438988	23438988	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:23438988C>T	ENST00000526079.1	+	0	571					NR_027407.1|NR_033350.1																						CCCCAGAGTCCACCCCATCCC	0.632000													3	9					0	0	1	0	0
BHLHE22	27319	broad.mit.edu	37	8	65493764	65493764	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:65493764C>T	ENST00000321870.1	+	1	951	c.417C>T	c.(415-417)gcC>gcT	p.A139A	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	139	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						GCTCGGTGGCCGAGAGCAGCG	0.751000													4	3					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034562	52034562	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52034562G>A	ENST00000346477.3	-	2	347	c.279C>T	c.(277-279)ttC>ttT	p.F93F	SIGLEC6_ENST00000391797.3_Silent_p.F93F|SIGLEC6_ENST00000436458.1_Silent_p.F57F|SIGLEC6_ENST00000359982.4_Silent_p.F93F|SIGLEC6_ENST00000343300.4_Silent_p.F93F|SIGLEC6_ENST00000425629.3_Silent_p.F93F	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	93	Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		AGAGGAGGTGGAATCGGCCCC	0.552000													35	108					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234749364	234749364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234749364G>A	ENST00000411486.2	-	8	2127	c.2062C>T	c.(2062-2064)Ccc>Tcc	p.P688S	HJURP_ENST00000432087.1_Missense_Mutation_p.P634S|HJURP_ENST00000441687.1_Missense_Mutation_p.P603S	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	688					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		GAGCCCTGGGGTTCTGATAGC	0.592000													29	100					0	0	1	0	0
SHC2	25759	broad.mit.edu	37	19	422388	422388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:422388G>A	ENST00000264554.6	-	11	1377	c.1378C>T	c.(1378-1380)Ccc>Tcc	p.P460S		NM_012435.2	NP_036567.2	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing) transforming protein 2	460	CH1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol				endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTCCAAGGGAAGAGGGGCT	0.687000													6	10					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604454	140604454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140604454C>T	ENST00000239449.4	+	1	1377	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	PCDHB14_ENST00000515856.2_Silent_p.F306F	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		459	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.607000													80	223					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457833	45457833	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45457833G>A	ENST00000548424.1	+	0	448																											GCTTTGTTTAGGCGAAAGGTC	0.458000													38	130					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924799	188924799	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:188924799C>T	ENST00000326866.4	+	4	1246	c.838C>T	c.(838-840)Caa>Taa	p.Q280*	ZFP42_ENST00000509524.1_Nonsense_Mutation_p.Q280*	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	280					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GTGTCCCTTTCAAGGCTGCAA	0.483000													24	34					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50208333	50208333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50208333C>T	ENST00000392518.4	+	9	1213	c.841C>T	c.(841-843)Ctg>Ttg	p.L281L	CPT1C_ENST00000405931.2_Silent_p.L270L|CPT1C_ENST00000323446.5_Silent_p.L281L|CPT1C_ENST00000354199.5_Silent_p.L281L|CPT1C_ENST00000598293.1_Silent_p.L281L	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	281					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TGCCCTCCTCCTGTACCGCCA	0.652000													22	76					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7862555	7862555	+	Missense_Mutation	SNP	C	C	T	rs150526011	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7862555C>T	ENST00000283147.6	+	4	1187	c.1028C>T	c.(1027-1029)gCc>gTc	p.A343V		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	343			A -> D (in a colorectal cancer sample; somatic mutation).		BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity	p.A343D(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					CACCCCCGAGCCGCAGGCCTG	0.532000													55	134					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280694	152280694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152280694G>A	ENST00000368799.1	-	3	6703	c.6668C>T	c.(6667-6669)tCa>tTa	p.S2223L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2223	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCCACCAGTGAGTGTCTAGA	0.542000									Ichthyosis				122	266					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559762	140559762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140559762G>A	ENST00000239444.2	+	1	2392	c.2147G>A	c.(2146-2148)aGg>aAg	p.R716K		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		716					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGCTGTGTAGGAGGAGCAGG	0.657000													22	206					0	0	1	0	0
GPR148	344561	broad.mit.edu	37	2	131487659	131487659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131487659C>T	ENST00000309926.4	+	1	1017	c.935C>T	c.(934-936)cCc>cTc	p.P312L		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	312						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					ATGATGCTTCCCCGTGCCATG	0.592000													16	54					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167159920	167159920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:167159920C>T	ENST00000476257.1	-	10	1493	c.1195G>A	c.(1195-1197)Gga>Aga	p.G399R	SERPINI2_ENST00000264677.4_Missense_Mutation_p.G399R|SERPINI2_ENST00000471111.1_Missense_Mutation_p.G399R|SERPINI2_ENST00000461846.1_Missense_Mutation_p.G399R			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	399					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						AAATCTCTTCCTTTTATCTCC	0.328000													16	31					0	0	1	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69419661	69419661	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:69419661G>A	ENST00000333026.3	+	3	296		c.e3-1			NM_198512.1	NP_940914.1	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6						lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(1)	12						TGTACCCACAGGTGGCAGGCG	0.552000													13	15					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75192536	75192536	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:75192536G>A	ENST00000336926.6	-	10	861	c.835C>T	c.(835-837)Ctg>Ttg	p.L279L	HIP1_ENST00000434438.2_Silent_p.L279L	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	279					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						AAGTACTGCAGGTTGCTGGAG	0.582000			T	PDGFRB	CMML								9	72					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584834	1584834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1584834G>A	ENST00000381297.4	-	2	828	c.618C>T	c.(616-618)ttC>ttT	p.F206F		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	206						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGGTGATCACGAACGGGATGA	0.647000			T	CRLF2	"""B-ALL, Downs associated ALL"""								13	39					0	0	1	0	0
RGS4	5999	broad.mit.edu	37	1	163042253	163042253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:163042253C>T	ENST00000421743.2	+	3	564	c.404C>T	c.(403-405)tCc>tTc	p.S135F	RGS4_ENST00000491263.1_3'UTR|RGS4_ENST00000527809.1_Missense_Mutation_p.S20F|RGS4_ENST00000367906.3_Missense_Mutation_p.S20F|RGS4_ENST00000531057.1_Missense_Mutation_p.S38F|RGS4_ENST00000367909.6_Missense_Mutation_p.S38F|RGS4_ENST00000367908.4_Missense_Mutation_p.S38F	NM_001102445.2|NM_001113380.1	NP_001095915.1|NP_001106851.1	P49798	RGS4_HUMAN	regulator of G-protein signaling 4	38	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|upper_aerodigestive_tract(2)	21						CACAATTCTTCCCACAACAAG	0.383000													29	64					0	0	1	0	0
RABEPK	10244	broad.mit.edu	37	9	127990228	127990228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127990228C>T	ENST00000373538.3	+	6	876	c.566C>T	c.(565-567)cCt>cTt	p.P189L	RABEPK_ENST00000259460.8_Missense_Mutation_p.P138L|RABEPK_ENST00000394125.4_Missense_Mutation_p.P189L|RABEPK_ENST00000394124.4_3'UTR	NM_005833.3	NP_005824.2	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	189					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15						CTTGGAAATCCTCCATCTCCC	0.473000													26	56					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55539335	55539335	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55539335C>T	ENST00000219070.4	+	13	2473	c.1964C>T	c.(1963-1965)tCc>tTc	p.S655F	MMP2_ENST00000437642.2_Missense_Mutation_p.S605F|MMP2_ENST00000570308.1_Missense_Mutation_p.S579F|MMP2_ENST00000543485.1_Missense_Mutation_p.S579F	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	655	Hemopexin-like 4.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	AGCATCAAATCCGACTGGCTA	0.552000													57	89					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196659300	196659300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196659300C>T	ENST00000367429.4	+	9	1507	c.1267C>T	c.(1267-1269)Cca>Tca	p.P423S	CFH_ENST00000439155.2_Missense_Mutation_p.P423S|CFH_ENST00000359637.2_Missense_Mutation_p.P359S	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	423	Sushi 7.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						CTACGCTCTTCCAAAAGCGCA	0.418000													26	44					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531760	50531760	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50531760G>A	ENST00000374144.3	+	3	1458	c.1170G>A	c.(1168-1170)ggG>ggA	p.G390G	C10orf71_ENST00000323868.4_Silent_p.G390G			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	390										endometrium(1)	1						GCAAAAAAGGGAAAGAAAGTC	0.463000													28	85					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118516191	118516191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118516191C>T	ENST00000361417.2	+	17	3650	c.3239C>T	c.(3238-3240)cCc>cTc	p.P1080L	PHLDB1_ENST00000534672.1_3'UTR|PHLDB1_ENST00000524713.1_Missense_Mutation_p.P223L|PHLDB1_ENST00000356063.5_Missense_Mutation_p.P1033L|PHLDB1_ENST00000527898.1_Missense_Mutation_p.P131L	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	1080										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCAGCGGGCCCCTCGGGCTTC	0.672000													25	98					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	921181	921181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:921181G>A	ENST00000262301.11	-	7	1076	c.1058C>T	c.(1057-1059)gCc>gTc	p.A353V	LMF1_ENST00000399843.2_Missense_Mutation_p.A353V|LMF1_ENST00000543238.1_Missense_Mutation_p.A116V|LMF1_ENST00000568897.1_Missense_Mutation_p.A136V|LMF1_ENST00000568268.1_5'UTR	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	353						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				CTCGGGCCGGGCCCCTCGGAT	0.672000													3	3					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29296878	29296878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29296878C>T	ENST00000331664.5	-	1	249	c.250G>A	c.(250-252)Ggc>Agc	p.G84S		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	84					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TTCCTTTTGCCTGAAGCAGGA	0.507000													17	165					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129712754	129712754	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:129712754G>A	ENST00000421865.2	+	36	5239	c.5190G>A	c.(5188-5190)agG>agA	p.R1730R		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1730	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AACTGAGGAGGAAAAATCTAG	0.353000													34	41					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72473661	72473661	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72473661G>A	ENST00000360141.3	+	4	908	c.620G>A	c.(619-621)tGg>tAg	p.W207*	CD300A_ENST00000577511.1_Nonsense_Mutation_p.W77*|CD300A_ENST00000392625.3_Nonsense_Mutation_p.W94*|CD300A_ENST00000310828.5_Nonsense_Mutation_p.W94*|CD300A_ENST00000361933.3_Intron	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	207					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						TTTCAGAAATGGATCAAAGGT	0.597000													6	35					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119929406	119929406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119929406C>T	ENST00000361035.4	+	6	1045	c.762C>T	c.(760-762)atC>atT	p.I254I	HAO2_ENST00000325945.3_Silent_p.I241I	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	241	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TCCAGGGTATCATTGTTTCCA	0.453000													33	95					0	0	1	0	0
VIPR1	7433	broad.mit.edu	37	3	42567411	42567411	+	Missense_Mutation	SNP	G	G	A	rs35925925		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42567411G>A	ENST00000433647.1	+	5	826	c.202G>A	c.(202-204)Ggc>Agc	p.G68S	VIPR1-AS1_ENST00000452639.2_RNA|VIPR1_ENST00000543411.1_Missense_Mutation_p.G62S|VIPR1-AS1_ENST00000602176.1_RNA|VIPR1_ENST00000438259.2_5'UTR|VIPR1-AS1_ENST00000600342.1_RNA|VIPR1-AS1_ENST00000593621.1_RNA|VIPR1_ENST00000325123.4_Missense_Mutation_p.G109S|VIPR1-AS1_ENST00000598837.1_RNA|VIPR1-AS1_ENST00000593611.1_RNA|VIPR1_ENST00000473575.1_3'UTR|VIPR1-AS1_ENST00000596630.1_RNA|VIPR1-AS1_ENST00000601312.1_RNA	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	109					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		CACCGACGAAGGCTGGACGCA	0.642000													4	11					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196737056	196737056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196737056G>A	ENST00000312428.6	-	40	6651	c.6551C>T	c.(6550-6552)tCc>tTc	p.S2184F		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2184	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATGACACGGGAGAAATCACG	0.388000													13	165					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140729881	140729881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140729881C>T	ENST00000523390.1	+	1	54	c.54C>T	c.(52-54)ttC>ttT	p.F18F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTTCCCTTCCTGCTGTCTT	0.522000											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	26					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	158334200	158334200	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:158334200C>T	ENST00000404321.2	-	1	98	c.99G>A	c.(97-99)gtG>gtA	p.V33V	PTPRN2_ENST00000389413.3_Intron|PTPRN2_ENST00000409483.1_Intron|PTPRN2_ENST00000389416.4_Intron|PTPRN2_ENST00000389418.4_Intron			Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	0						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AAACAAACATCACTTCCACCC	0.532000													30	88					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125833454	125833454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125833454C>T	ENST00000393434.2	-	18	2377	c.2028G>A	c.(2026-2028)ggG>ggA	p.G676G	ALDH1L1_ENST00000393431.2_Intron|ALDH1L1_ENST00000472186.1_Silent_p.G676G|ALDH1L1_ENST00000452905.2_Silent_p.G575G|ALDH1L1_ENST00000273450.3_Silent_p.G686G	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	676	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GGGGTGACTTCCCGCCCAGTT	0.617000													37	73					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30433001	30433001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30433001G>A	ENST00000375978.3	-	1	419	c.345C>T	c.(343-345)acC>acT	p.T115T		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	115					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CTGTCTGCCGGGTGAAGCGGC	0.701000													10	32					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41084153	41084153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:41084153C>T	ENST00000324545.7	+	40	7543	c.6910C>T	c.(6910-6912)Cgt>Tgt	p.R2304C	USP9X_ENST00000378308.2_Missense_Mutation_p.R2304C	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	2304					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CAAATTGCTTCGTTTTTGCTG	0.363000													21	85					0	0	1	0	0
CALML6	163688	broad.mit.edu	37	1	1848629	1848629	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1848629G>A	ENST00000307786.3	+	6	997	c.543G>A	c.(541-543)caG>caA	p.Q181Q		NM_138705.2	NP_619650.2	Q8TD86	CALL6_HUMAN	calmodulin-like 6	181						cytoplasm|nucleus	calcium ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(1)|prostate(2)	7	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.94e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.83e-23)|GBM - Glioblastoma multiforme(42;3.23e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		AGCTGATCCAGTAGGTGCAGC	0.667000													3	8					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19634720	19634720	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19634720C>T	ENST00000328041.6	+	7	824	c.627C>T	c.(625-627)tcC>tcT	p.S209S		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	209						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TGGCTCTTTCCTCCTGGTGCC	0.507000													11	78					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55815081	55815081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55815081G>A	ENST00000309383.1	+	12	1450	c.1173G>A	c.(1171-1173)ggG>ggA	p.G391G	BRSK1_ENST00000326848.7_Silent_p.G86G|BRSK1_ENST00000590333.1_Silent_p.G407G	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	391			G -> E (in a metastatic melanoma sample; somatic mutation).		establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCCGTCACGGGAAGCGGCGAC	0.622000													30	102					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156997953	156997953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156997953C>T	ENST00000257527.4	-	2	208	c.130G>A	c.(130-132)Gaa>Aaa	p.E44K	ADAM19_ENST00000430702.2_5'UTR|ADAM19_ENST00000517905.1_Missense_Mutation_p.E44K|ADAM19_ENST00000394020.1_Missense_Mutation_p.E46K	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	44					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGATAAGTTCATGCTGCAGC	0.483000													33	70					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114223968	114223968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114223968G>A	ENST00000357077.4	+	23	2574	c.2521G>A	c.(2521-2523)Gag>Aag	p.E841K	ANK2_ENST00000509550.1_Missense_Mutation_p.E50K|ANK2_ENST00000264366.6_Missense_Mutation_p.E841K|ANK2_ENST00000506722.1_Missense_Mutation_p.E820K|ANK2_ENST00000394537.3_Missense_Mutation_p.E841K	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	841					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GACGATGACTGAGGTTCTTGA	0.333000													31	95					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93979219	93979219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:93979219C>T	ENST00000369303.4	-	7	1793	c.1609G>A	c.(1609-1611)Gaa>Aaa	p.E537K		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	537						integral to plasma membrane	ATP binding|ephrin receptor activity	p.E537K(1)		NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CCTGTAGCTTCCTCTAGTGTA	0.363000													34	59					0	0	1	0	0
TES	26136	broad.mit.edu	37	7	115890401	115890401	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:115890401G>A	ENST00000358204.4	+	4	768	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	TES_ENST00000393481.2_Missense_Mutation_p.E176K|AC002066.1_ENST00000446355.2_RNA|TES_ENST00000537767.1_Intron|AC073130.3_ENST00000444244.1_RNA	NM_015641.3	NP_056456.1	Q9UGI8	TES_HUMAN	testis derived transcript (3 LIM domains)	185	PET.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding			endometrium(4)|large_intestine(4)|lung(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	12	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			ATATAAGAGCGAAGCTCTGGG	0.512000													26	52					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30020383	30020383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30020383G>A	ENST00000350119.4	-	5	651	c.461C>T	c.(460-462)cCc>cTc	p.P154L	DOC2A_ENST00000564944.1_Missense_Mutation_p.P154L|DOC2A_ENST00000564979.1_Missense_Mutation_p.P154L	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	154	C2 1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						ATTCCACACGGGATTCAGTGT	0.567000													8	51					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58639429	58639429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58639429C>T	ENST00000358781.2	-	3	403	c.93G>A	c.(91-93)atG>atA	p.M31I		NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	31					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		GGATGGTTTTCATGCTGAAGC	0.577000													59	146					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6729468	6729468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6729468C>T	ENST00000329858.4	-	2	1703	c.947G>A	c.(946-948)cGg>cAg	p.R316Q	LPAR5_ENST00000431922.1_Missense_Mutation_p.R316Q	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	316						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						GGTCCTGGCCCGGTGCGGAGT	0.721000													4	9					0	0	1	0	0
LETMD1	25875	broad.mit.edu	37	12	51442255	51442255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51442255C>T	ENST00000418425.2	+	1	135	c.116C>T	c.(115-117)gCc>gTc	p.A39V	LETMD1_ENST00000547008.1_Missense_Mutation_p.A39V|LETMD1_ENST00000548516.1_Intron|LETMD1_ENST00000380123.2_Missense_Mutation_p.A39V|LETMD1_ENST00000552739.1_Missense_Mutation_p.A39V|LETMD1_ENST00000262055.4_Missense_Mutation_p.A39V|LETMD1_ENST00000550929.1_Intron	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	39	Required and sufficient for mitochondrial import.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						GCTTGGGGGGCCCCTCGGTGA	0.577000											OREG0021818	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	77					0	0	1	0	0
PHTF2	57157	broad.mit.edu	37	7	77569557	77569557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:77569557C>T	ENST00000416283.2	+	12	1702	c.1576C>T	c.(1576-1578)Cgc>Tgc	p.R526C	PHTF2_ENST00000275575.7_Missense_Mutation_p.R522C|PHTF2_ENST00000248550.7_Missense_Mutation_p.R560C|PHTF2_ENST00000424760.1_Missense_Mutation_p.R522C|PHTF2_ENST00000307305.8_Missense_Mutation_p.R522C|PHTF2_ENST00000422959.2_Missense_Mutation_p.R526C	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						TTTTGTGGTTCGCGTGTCTCT	0.338000													33	94					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35547981	35547981	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35547981C>T	ENST00000536438.1	-	10	1173	c.858G>A	c.(856-858)caG>caA	p.Q286Q	FKBP5_ENST00000540787.1_Silent_p.Q107Q|FKBP5_ENST00000357266.4_Silent_p.Q286Q|FKBP5_ENST00000539068.1_Silent_p.Q286Q	NM_001145775.1	NP_001139247.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	286					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						GAATCACCGCCTGCATGTATT	0.428000													22	246					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21158759	21158759	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21158759C>T	ENST00000377122.4	-	6	888	c.492G>A	c.(490-492)agG>agA	p.R164R	NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron|NEBL_ENST00000377119.1_Silent_p.R164R	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	164					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GCACGTCTTTCCTATAAGAAA	0.363000													16	70					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	30054406	30054406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:30054406G>A	ENST00000431530.3	+	8	3392	c.3334G>A	c.(3334-3336)Gag>Aag	p.E1112K	MTUS2_ENST00000542829.1_5'UTR|MTUS2_ENST00000380808.2_Missense_Mutation_p.E81K|MTUS2-AS1_ENST00000323380.4_RNA	NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	1102	Localization to the growing distal tip of microtubules.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GGAGCTGGAGGAGCGGCTGCA	0.632000													3	3					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57473361	57473361	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:57473361G>A	ENST00000374900.4	+	9	1237	c.1116_splice	c.e9-1	p.E373_splice	FAAH2_ENST00000491179.1_Intron	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	373						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						TCAATCTCAGGAACCTGTGAA	0.363000										HNSCC(52;0.14)			6	9					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80667094	80667094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:80667094G>A	ENST00000299564.8	-	3	811	c.656C>T	c.(655-657)cCa>cTa	p.P219L	CDYL2_ENST00000563890.1_Missense_Mutation_p.P220L|CDYL2_ENST00000562812.1_Missense_Mutation_p.P220L|CDYL2_ENST00000566173.1_Missense_Mutation_p.P220L	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	219						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						CCTCTTCACTGGACTGTGCAG	0.483000													35	109					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43258539	43258539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43258539G>A	ENST00000404209.4	-	5	1285	c.1189C>T	c.(1189-1191)Cgt>Tgt	p.R397C	PSG8_ENST00000406636.3_Missense_Mutation_p.R275C|PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000306511.4_Missense_Mutation_p.R397C|PSG8_ENST00000401467.2_Missense_Mutation_p.R304C	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	397	Ig-like C2-type 3.					extracellular region		p.R397C(2)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GCTGAGTTACGAACAGAGCAA	0.448000													39	655					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38482250	38482250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38482250C>T	ENST00000263409.4	-	20	2903	c.2741G>A	c.(2740-2742)cGa>cAa	p.R914Q	LIFR_ENST00000453190.2_Missense_Mutation_p.R914Q	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	914					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					AAATGCTGATCGAGTTTCCAG	0.388000			T	PLAG1	salivary adenoma								44	93					0	0	1	0	0
ANO6	196527	broad.mit.edu	37	12	45742408	45742408	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:45742408C>T	ENST00000320560.8	+	6	943	c.741C>T	c.(739-741)ctC>ctT	p.L247L	ANO6_ENST00000423947.3_Silent_p.L268L|ANO6_ENST00000426898.2_3'UTR|ANO6_ENST00000441606.2_Silent_p.L229L|ANO6_ENST00000435642.1_Silent_p.L247L|ANO6_ENST00000425752.2_Silent_p.L247L	NM_001025356.2	NP_001020527.2	Q4KMQ2	ANO6_HUMAN	anoctamin 6	247					activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						CTTTCCCACTCCATGATGTAA	0.403000													13	72					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176128	140176128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140176128G>A	ENST00000526136.1	+	1	1579	c.1579G>A	c.(1579-1581)Gaa>Aaa	p.E527K	PCDHA2_ENST00000378132.1_Missense_Mutation_p.E527K|PCDHA2_ENST00000520672.2_Missense_Mutation_p.E527K|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCACGAGGAAGTGGAGCT	0.687000													47	122					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109793637	109793637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:109793637C>T	ENST00000356711.2	+	32	5137	c.5011C>T	c.(5011-5013)Ccc>Tcc	p.P1671S	MYO16_ENST00000357550.2_Missense_Mutation_p.P1671S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1671	Pro-rich.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCTCAGCAGCCCCCTGGACGA	0.672000													7	16					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169412861	169412861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169412861C>T	ENST00000256935.8	+	29	3008	c.2928C>T	c.(2926-2928)ttC>ttT	p.F976F	DOCK2_ENST00000540750.1_Silent_p.F37F|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Silent_p.F468F	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	976	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATCATGTTCAAGGACCTCA	0.468000													50	140					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24503662	24503662	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:24503662G>A	ENST00000357578.3	+	3	754		c.e3+1		ALDH5A1_ENST00000491546.1_Splice_Site|ALDH5A1_ENST00000546278.1_Splice_Site|ALDH5A1_ENST00000348925.2_Splice_Site	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1						acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	CATCACCCCGGTAGGTGACAG	0.562000													17	40					0	0	1	0	0
NPHP1	4867	broad.mit.edu	37	2	110902115	110902115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:110902115G>A	ENST00000316534.4	-	15	1625	c.1552C>T	c.(1552-1554)Cct>Tct	p.P518S	NPHP1_ENST00000393272.3_Missense_Mutation_p.P517S|NPHP1_ENST00000355301.4_Missense_Mutation_p.P399S|NPHP1_ENST00000417665.1_Missense_Mutation_p.P461S|NPHP1_ENST00000445609.2_Missense_Mutation_p.P462S			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	517					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						TTTTCATAAGGAGTACCACCA	0.358000													33	70					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219892338	219892338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219892338C>T	ENST00000409865.3	-	13	2215	c.2212G>A	c.(2212-2214)Gtc>Atc	p.V738I	CCDC108_ENST00000341552.5_Intron|CCDC108_ENST00000453220.1_Intron|CCDC108_ENST00000410037.1_Missense_Mutation_p.V684I|CCDC108_ENST00000441968.1_Intron	NM_001278295.1	NP_001265224.1	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	0						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTAGCAGAGACCCCGCATTCC	0.607000													31	79					0	0	1	0	0
ACTG1P17	283693	broad.mit.edu	37	15	83395078	83395078	+	RNA	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83395078A>G	ENST00000560958.1	-	0	1208					NR_036446.1																						TTTGCGGTGAACAGTGGAGGG	0.502000													9	33					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34006106	34006106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34006106G>A	ENST00000297161.2	+	5	709	c.335G>A	c.(334-336)gGa>gAa	p.G112E	BMPER_ENST00000426693.1_Missense_Mutation_p.G112E	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	112	VWFC 2.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						ACCTATGAAGGAAATACCTAT	0.438000													13	48					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102824912	102824912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102824912C>T	ENST00000260302.3	-	4	638	c.610G>A	c.(610-612)Gat>Aat	p.D204N	MMP13_ENST00000340273.4_Missense_Mutation_p.D204N	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	204					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		CAGGTTTCATCATCATCAAAA	0.408000													7	53					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	88249327	88249327	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:88249327C>T	ENST00000518476.1	+	6	809	c.758C>T	c.(757-759)tCa>tTa	p.S253L	CNBD1_ENST00000522427.1_3'UTR	NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	253										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						TACCTACCTTCATATGACTCA	0.383000													19	40					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154124377	154124377	+	Missense_Mutation	SNP	C	C	T	rs137852366		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:154124377C>T	ENST00000360256.4	-	22	6604	c.6404G>A	c.(6403-6405)cGa>cAa	p.R2135Q		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2135	F5/8 type C 1.		R -> P (in HEMA; severe).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGAATTTCCTCGATAAGTCTG	0.408000													24	113					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15497228	15497228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:15497228C>T	ENST00000341776.2	+	7	2016	c.1772C>T	c.(1771-1773)cCc>cTc	p.P591L	JARID2_ENST00000541660.1_Missense_Mutation_p.P553L|JARID2_ENST00000397311.3_Missense_Mutation_p.P419L	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	591	JmjN.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGGGTGATCCCCCCTCCGGAC	0.642000													4	26					0	0	1	0	0
TIPARP	25976	broad.mit.edu	37	3	156395948	156395948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:156395948C>T	ENST00000461166.1	+	2	1050	c.462C>T	c.(460-462)tcC>tcT	p.S154S	TIPARP_ENST00000486483.1_Silent_p.S154S|TIPARP_ENST00000295924.7_Silent_p.S154S|TIPARP_ENST00000542783.1_Silent_p.S154S	NM_001184717.1	NP_001171646.1	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	154							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TGGCAGATTCCACACCAGCTC	0.488000													59	145					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31391694	31391694	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31391694C>T	ENST00000268296.4	+	27	3289	c.3168C>T	c.(3166-3168)gtC>gtT	p.V1056V	ITGAX_ENST00000562522.1_Silent_p.V1056V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	1056					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TTGGCTGGGTCCGCCAGGTGT	0.647000													6	19					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158589027	158589027	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158589027C>T	ENST00000368148.3	-	45	6695	c.6515G>A	c.(6514-6516)tGg>tAg	p.W2172*	SPTA1_ENST00000368147.3_Nonsense_Mutation_p.W2169*	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2172					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTCCAGGATCCATTGAAGGAA	0.483000													63	133					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38766682	38766682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38766682G>A	ENST00000449082.2	-	17	3210	c.3211C>T	c.(3211-3213)Cct>Tct	p.P1071S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1071					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGGACCTGAGGAACAGACTCA	0.607000													21	42					0	0	1	0	0
NT5DC3	51559	broad.mit.edu	37	12	104190698	104190698	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104190698G>A	ENST00000392876.3	-	6	767	c.727C>T	c.(727-729)Cct>Tct	p.P243S	NT5DC3_ENST00000465502.1_5'UTR	NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	243							hydrolase activity|metal ion binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						AGATGCACAGGCTCATAGTCG	0.468000													26	134					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068408	5068408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5068408C>T	ENST00000380370.1	+	1	653	c.653C>T	c.(652-654)tCg>tTg	p.S218L		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTGGCATCTCGTATGTTTAC	0.453000													66	162					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25264389	25264389	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25264389G>A	ENST00000400358.4	+	11	1098	c.1041G>A	c.(1039-1041)caG>caA	p.Q347Q	SGSM1_ENST00000400359.4_Silent_p.Q347Q	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	347	Required for interaction with RAP family members.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						ACGGGATCCAGAGGCCGCCCT	0.642000													24	53					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107022146	107022146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:107022146G>A	ENST00000369701.3	+	26	3728	c.3501G>A	c.(3499-3501)atG>atA	p.M1167I		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1167						integral to membrane	neuropeptide receptor activity	p.M1167I(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGCAGGAGATGATTGGGTCAG	0.498000													27	59					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41694356	41694356	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:41694356C>T	ENST00000313860.7	+	26	3235	c.3181C>T	c.(3181-3183)Cga>Tga	p.R1061*	RP11-227F19.5_ENST00000506475.1_RNA|LIMCH1_ENST00000513024.1_Nonsense_Mutation_p.R888*|LIMCH1_ENST00000396595.3_Nonsense_Mutation_p.R880*|LIMCH1_ENST00000381753.4_Nonsense_Mutation_p.R868*|LIMCH1_ENST00000512946.1_Nonsense_Mutation_p.R1035*|LIMCH1_ENST00000514096.1_Nonsense_Mutation_p.R875*|LIMCH1_ENST00000509277.1_Nonsense_Mutation_p.R894*|LIMCH1_ENST00000512820.1_Nonsense_Mutation_p.R1047*|LIMCH1_ENST00000508501.1_Nonsense_Mutation_p.R1034*|LIMCH1_ENST00000503057.1_Nonsense_Mutation_p.R1445*|LIMCH1_ENST00000512632.1_Nonsense_Mutation_p.R958*|LIMCH1_ENST00000511496.1_Nonsense_Mutation_p.R875*	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	1061	LIM zinc-binding.				actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TGTTAGGATTCGAAATGGTCT	0.428000													13	68					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23409421	23409421	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23409421G>A	ENST00000307149.5	-	14	2018	c.1833C>T	c.(1831-1833)acC>acT	p.T611T		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	611					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		CATCTGTGAGGGTTTCTCCGA	0.532000													14	37					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38317410	38317410	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38317410C>T	ENST00000311856.4	+	7	1109	c.1060C>T	c.(1060-1062)Caa>Taa	p.Q354*	SLC22A13_ENST00000450935.2_3'UTR	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	354						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		CCTGAGCCTCCAAGTGGGGGA	0.572000													19	48					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140532154	140532154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140532154C>T	ENST00000231136.1	+	1	2316	c.2316C>T	c.(2314-2316)ttC>ttT	p.F772F	PCDHB6_ENST00000543635.1_Silent_p.F636F	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		772					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCCCAACTTCCCTCCTCAGG	0.483000													26	96					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91780176	91780176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91780176C>T	ENST00000389857.6	-	15	2070	c.1984G>A	c.(1984-1986)Gag>Aag	p.E662K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	662					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TCCAGGGCCTCGACTTTCTCG	0.632000													5	22					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38760200	38760200	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38760200C>T	ENST00000449082.2	-	20	3624	c.3625G>A	c.(3625-3627)Ggc>Agc	p.G1209S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1209					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTTTTGAAGCCATAGGCCACC	0.527000													30	96					0	0	1	0	0
C4B	721	broad.mit.edu	37	6	31997527	31997527	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31997527C>T	ENST00000435363.2	+	29	3945	c.3861C>T	c.(3859-3861)gcC>gcT	p.A1287A	C4B_ENST00000425700.2_Silent_p.A1287A	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1287					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										AGGCTGCGGCCTGGCTCACCC	0.667000													24	96					0	0	1	0	0
OR5D14	219436	broad.mit.edu	37	11	55563286	55563286	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55563286G>A	ENST00000335605.1	+	1	255	c.255G>A	c.(253-255)gaG>gaA	p.E85E		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				AGCTGCTTGAGAACTTGGTAA	0.423000													18	68					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32567576	32567576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:32567576G>A	ENST00000286827.3	-	14	3010	c.2539C>T	c.(2539-2541)Cac>Tac	p.H847Y	TIAM1_ENST00000541036.1_Missense_Mutation_p.H787Y	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	847	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity	p.H847Y(1)		autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TTCTCAATGTGGATGCTCTGA	0.303000													14	53					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20422911	20422911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20422911C>T	ENST00000331849.4	+	2	252	c.105C>T	c.(103-105)atC>atT	p.I35I	ACSM5_ENST00000575584.1_Silent_p.I35I	NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	35					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CTCAGAAGATCGTGGCCACCT	0.582000													15	37					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135561040	135561040	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:135561040C>T	ENST00000513104.1	-	10	2547	c.2265G>A	c.(2263-2265)aaG>aaA	p.K755K	TRPC7_ENST00000426057.2_Silent_p.K639K|TRPC7_ENST00000355180.3_Silent_p.K694K	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	755					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTAGCGAGTCTTCTGGATAA	0.453000													4	18					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36370056	36370056	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36370056C>T	ENST00000221891.4	+	16	1986	c.1794C>T	c.(1792-1794)gtC>gtT	p.V598V	APLP1_ENST00000537454.2_Silent_p.V558V|APLP1_ENST00000586861.1_Silent_p.V591V	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	597					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCTCATCGTCCTCTCCATGC	0.642000													27	46					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55175707	55175707	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55175707G>A	ENST00000421030.2	+	24	4104	c.3819G>A	c.(3817-3819)caG>caA	p.Q1273Q	MROH7_ENST00000414150.2_Intron|MROH7_ENST00000409996.1_Silent_p.Q841Q|MROH7_ENST00000454855.2_Silent_p.Q791Q	NM_001039464.2	NP_001034553.2			maestro heat-like repeat family member 7																		GCTGCTGGCAGAACTCCTGGC	0.617000													6	62					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57863320	57863320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57863320G>A	ENST00000228682.2	+	11	1506	c.1415G>A	c.(1414-1416)gGg>gAg	p.G472E	GLI1_ENST00000546141.1_Missense_Mutation_p.G431E|GLI1_ENST00000543426.1_Missense_Mutation_p.G344E	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	472					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			GGCAATGCAGGGGGCAGCACT	0.612000													23	87					0	0	1	0	0
RNF6	6049	broad.mit.edu	37	13	26789453	26789453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:26789453G>A	ENST00000381588.4	-	5	1318	c.566C>T	c.(565-567)tCa>tTa	p.S189L	RNF6_ENST00000346166.3_Missense_Mutation_p.S189L|RNF6_ENST00000399762.2_Intron|RNF6_ENST00000381570.3_Missense_Mutation_p.S189L|RNF6_ENST00000468480.1_Intron	NM_005977.3	NP_005968.1	Q9Y252	RNF6_HUMAN	ring finger protein (C3H2C3 type) 6	189					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(3)|ovary(2)|prostate(2)|skin(2)	23	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		AGGACTAGTTGACCTTTGTTG	0.403000													18	275					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179644044	179644044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179644044C>T	ENST00000589042.1	-	23	4099	c.3875G>A	c.(3874-3876)gGa>gAa	p.G1292E	RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G1292E|TTN_ENST00000360870.5_Missense_Mutation_p.G1292E|TTN_ENST00000591111.1_Missense_Mutation_p.G1292E|TTN_ENST00000342175.6_Missense_Mutation_p.G1246E|TTN_ENST00000359218.5_Missense_Mutation_p.G1246E|TTN_ENST00000460472.2_Missense_Mutation_p.G1246E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1292	Ig-like 5.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAATCAAATCCTGATTCAAC	0.328000													12	54					0	0	1	0	0
COLEC10	10584	broad.mit.edu	37	8	120101930	120101930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:120101930G>A	ENST00000332843.2	+	2	201	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	COLEC10_ENST00000521788.1_3'UTR	NM_006438.3	NP_006429.2	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 (C-type lectin)	54	Collagen-like.					collagen|cytoplasm	mannose binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			AGATGATGGTGAAAAAGGAGA	0.413000													15	37					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47593172	47593172	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47593172G>A	ENST00000273859.3	+	23	4324	c.4055G>A	c.(4054-4056)gGg>gAg	p.G1352E		NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1352					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						AAGTGGAGAGGGGCTGGAAAG	0.473000													24	91					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43237428	43237428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43237428C>T	ENST00000304139.5	+	13	2043	c.1881C>T	c.(1879-1881)ccC>ccT	p.P627P	TTBK1_ENST00000259750.4_Intron			Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	680						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGTACAGCCCCCTGCGACGAC	0.652000													16	26					0	0	1	0	0
CNNM1	26507	broad.mit.edu	37	10	101147941	101147941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101147941G>A	ENST00000356713.4	+	9	2846	c.2557G>A	c.(2557-2559)Gag>Aag	p.E853K	CNNM1_ENST00000446890.1_Missense_Mutation_p.E782K|CNNM1_ENST00000370534.4_Missense_Mutation_p.E509K|CNNM1_ENST00000370528.3_Intron	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	853					ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		AAGCCCCAGCGAGGTAGTGTA	0.607000													16	59					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98744436	98744436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98744436C>T	ENST00000286067.2	+	1	3396	c.3289C>T	c.(3289-3291)Cct>Tct	p.P1097S		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	1097										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AGGCAGCAGCCCTCCAGATAG	0.512000													9	58					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42168793	42168793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42168793C>T	ENST00000444063.1	+	17	2038	c.1906C>T	c.(1906-1908)Ctc>Ttc	p.L636F	L3MBTL1_ENST00000427442.2_Missense_Mutation_p.L704F|L3MBTL1_ENST00000373134.1_Missense_Mutation_p.L641F|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.L636F|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.L704F			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	636					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						CTTTCCAGCCCTCACGCCCGA	0.612000													12	49					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45478136	45478136	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:45478136C>T	ENST00000361462.2	+	6	3108	c.2925C>T	c.(2923-2925)tcC>tcT	p.S975S	KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Silent_p.S975S|FAM179B_ENST00000382233.2_Intron			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	975	Ser-rich.						binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						CTCTTAGGTCCCTTCGTAATA	0.348000													27	74					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117106777	117106777	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117106777C>T	ENST00000262820.3	-	1	924	c.15G>A	c.(13-15)tgG>tgA	p.W5*	KLHL13_ENST00000371878.1_Intron|KLHL13_ENST00000371882.1_Intron|KLHL13_ENST00000541812.1_Intron|KLHL13_ENST00000545703.1_Intron|KLHL13_ENST00000469946.1_Intron|KLHL13_ENST00000539496.1_Intron|KLHL13_ENST00000540167.1_Intron	NM_033495.3	NP_277030.2	Q9P2N7	KLH13_HUMAN	kelch-like family member 13	5					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AGCTCGTTTTCCATTTCAATG	0.418000													27	18					0	0	1	0	0
KCNK9	51305	broad.mit.edu	37	8	140630507	140630507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:140630507G>A	ENST00000520439.1	-	2	1182	c.1119C>T	c.(1117-1119)tcC>tcT	p.S373S	KCNK9_ENST00000303015.1_Silent_p.S373S			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	373						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			ACACCTAAACGGACTTCCGGC	0.433000													30	162					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197403941	197403941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197403941G>A	ENST00000367397.1	+	5	1949	c.1091G>A	c.(1090-1092)aGg>aAg	p.R364K	CRB1_ENST00000544212.1_Missense_Mutation_p.R464K|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.R871K|CRB1_ENST00000535699.1_Missense_Mutation_p.R959K|CRB1_ENST00000367400.3_Missense_Mutation_p.R983K			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	983	EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TTCAGAACAAGGGATGCAAAT	0.338000													21	107					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110831287	110831287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110831287C>T	ENST00000375820.4	-	31	2562	c.2441G>A	c.(2440-2442)gGa>gAa	p.G814E		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	814	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCCCGGTGGTCCCTGTCCTCC	0.587000													8	13					0	0	1	0	0
CPLX3	594855	broad.mit.edu	37	15	75122542	75122542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75122542G>A	ENST00000395018.4	+	3	481	c.324G>A	c.(322-324)atG>atA	p.M108I	RP11-414J4.2_ENST00000564823.1_RNA	NM_001030005.2	NP_001025176.1	Q8WVH0	CPLX3_HUMAN	complexin 3	108						cell junction|synapse	syntaxin binding			large_intestine(2)|lung(2)	4						TGGCCAAGATGATCGAGGAGG	0.622000													19	95					0	0	1	0	0
IGLV5-48	28780	broad.mit.edu	37	22	22707693	22707693	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22707693C>T	ENST00000390293.1	+	0	281																											AAAGATGCTTCGAGCAATGCA	0.517000													45	100					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64225436	64225436	+	Missense_Mutation	SNP	C	C	T	rs149659675	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:64225436C>T	ENST00000205948.6	-	1	99	c.62G>A	c.(61-63)cGg>cAg	p.R21Q		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	21	Sushi 1.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			GTACTTACTCCGTCCTGCAAT	0.418000													8	34					0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53911378	53911378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53911378G>A	ENST00000335754.3	-	5	647	c.547C>T	c.(547-549)Cac>Tac	p.H183Y	ACTR8_ENST00000482349.1_Missense_Mutation_p.H72Y	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	183					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		ATAGGCCAGTGAATATTGTAA	0.423000													24	61					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39553606	39553606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39553606G>A	ENST00000251645.2	-	1	238	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	62	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				GGTCGTTCAGGAACTGCATAG	0.622000													52	83					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201182696	201182696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201182696G>A	ENST00000335211.4	+	12	8805	c.8675G>A	c.(8674-8676)aGt>aAt	p.S2892N	IGFN1_ENST00000295591.8_Missense_Mutation_p.S52N|IGFN1_ENST00000451870.2_Missense_Mutation_p.S435N	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCTACCCGGAGTTCCACATCC	0.572000													22	68					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150490215	150490215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150490215C>T	ENST00000447204.2	-	5	933	c.561G>A	c.(559-561)tgG>tgA	p.W187*	TMEM176B_ENST00000492607.1_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000450753.2_Nonsense_Mutation_p.W150*|TMEM176B_ENST00000326442.5_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000434545.1_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000429904.2_Nonsense_Mutation_p.W187*	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	187					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCCTTCTGCCATTGGTTCT	0.527000													15	92					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170063345	170063345	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170063345C>T	ENST00000263816.3	-	39	7170	c.6885G>A	c.(6883-6885)agG>agA	p.R2295R		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2295					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTTTCAAATTCCTATCTACCC	0.413000													37	74					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87180118	87180118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87180118C>T	ENST00000265724.3	-	11	1453	c.1036G>A	c.(1036-1038)Gga>Aga	p.G346R	ABCB1_ENST00000543898.1_Missense_Mutation_p.G282R	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	346	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GATGCCTGTCCAACACTAAAA	0.368000													31	58					0	0	1	0	0
SPRY3	10251	broad.mit.edu	37	X	155004272	155004272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:155004272C>T	ENST00000302805.2	+	2	1170	c.739C>T	c.(739-741)Ctg>Ttg	p.L247L		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	247	Cys-rich.|SPR.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATGCCTCCATCTGTGCCAACA	0.587000													82	170					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177317	89177317	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:89177317C>T	ENST00000561129.2	+	1	363	c.233C>T	c.(232-234)cCt>cTt	p.P78L	TGIF2LX_ENST00000283891.5_Missense_Mutation_p.P78L			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	78						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						AAGGCCTACCCTTCAGAAGAA	0.478000													72	37					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86370307	86370307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:86370307G>A	ENST00000400286.2	-	2	935	c.337C>T	c.(337-339)Ctc>Ttc	p.L113F		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	113						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TGTTTCAGGAGGCCAAGGCCA	0.363000													50	89					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134968304	134968304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:134968304C>T	ENST00000398015.3	+	15	3187	c.2817C>T	c.(2815-2817)tcC>tcT	p.S939S	EPHB1_ENST00000493838.1_Silent_p.S500S	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	939	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GCTTCACCTCCCTCCAGCTGG	0.552000													23	78					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26527408	26527408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26527408G>A	ENST00000456354.2	+	8	1142	c.1075G>A	c.(1075-1077)Gaa>Aaa	p.E359K		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	359					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCCTCCAGGAACCCCTTGC	0.577000													19	70					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220326713	220326713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220326713G>A	ENST00000312358.7	+	7	2682	c.2550G>A	c.(2548-2550)atG>atA	p.M850I	SPEG_ENST00000396698.1_Missense_Mutation_p.M746I|SPEG_ENST00000396688.1_Start_Codon_SNP_p.M1I|SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396686.1_Start_Codon_SNP_p.M1I|SPEG_ENST00000396689.2_Start_Codon_SNP_p.M1I|SPEG_ENST00000396695.2_Missense_Mutation_p.M58I	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	850					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCCCACCATGAAGCCCAGTC	0.647000													40	100					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18863935	18863935	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:18863935C>T	ENST00000317977.6	+	5	826	c.255C>T	c.(253-255)tcC>tcT	p.S85S	SLC5A10_ENST00000395642.1_Silent_p.S85S|SLC5A10_ENST00000395647.2_Silent_p.S141S|SLC5A10_ENST00000395645.3_Silent_p.S141S|SLC5A10_ENST00000417251.2_Silent_p.S141S|SLC5A10_ENST00000395643.2_Silent_p.S141S			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	141					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						CTGTCCTGTCCCTGCTACTGT	0.587000											OREG0024231	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	57					0	0	1	0	0
SV2C	22987	broad.mit.edu	37	5	75597272	75597272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75597272C>T	ENST00000502798.2	+	12	2344	c.1902C>T	c.(1900-1902)tcC>tcT	p.S634S	RP11-466P24.6_ENST00000502589.1_RNA|SV2C_ENST00000322285.7_Silent_p.S634S	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	634					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CCAGTGAATCCATGATGATAG	0.507000													40	184					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103124631	103124631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103124631G>A	ENST00000295269.4	+	5	1749	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	431					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GGTGTTCGAGGAGCTGGAAGT	0.398000													30	91					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43552318	43552318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43552318G>A	ENST00000220420.5	-	3	375	c.368C>T	c.(367-369)tCc>tTc	p.S123F	TGM5_ENST00000349114.4_Intron	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	123					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CCCCTGGAAGGAGTCGATGTG	0.627000													22	107					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699232	43699232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43699232C>T	ENST00000405312.3	-	4	1140	c.903G>A	c.(901-903)acG>acA	p.T301T	PSG4_ENST00000433626.2_Silent_p.T208T|PSG4_ENST00000244295.9_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	301	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region		p.T301T(1)		central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				TTTCATTTCTCGTGACATTGG	0.478000													35	301					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39019623	39019623	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39019623G>A	ENST00000355481.4	+	75	11183	c.11052G>A	c.(11050-11052)gaG>gaA	p.E3684E	RYR1_ENST00000359596.3_Silent_p.E3689E|RYR1_ENST00000360985.3_Silent_p.E3689E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3689					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	aggaggaagaggtggaagaga	0.612000													7	11					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37415610	37415610	+	Silent	SNP	G	G	A	rs140600686	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:37415610G>A	ENST00000535679.1	-	1	173	c.174C>T	c.(172-174)atC>atT	p.I58I	SULT6B1_ENST00000407963.1_Silent_p.I20I|SULT6B1_ENST00000260637.3_Silent_p.I20I|SULT6B1_ENST00000379149.2_Silent_p.I58I			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	58						cytoplasm	sulfotransferase activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				ATGCTAGCACGATGTCATCAT	0.463000													21	110					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813799	123813799	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123813799G>A	ENST00000321252.2	-	1	781	c.747C>T	c.(745-747)gtC>gtT	p.V249V		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CATAGATGATGACCACCACTG	0.512000													31	87					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18320445	18320445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18320445G>A	ENST00000396253.3	-	9	1178	c.716C>T	c.(715-717)tCc>tTc	p.S239F	HPS5_ENST00000438420.2_Missense_Mutation_p.S239F|HPS5_ENST00000349215.3_Missense_Mutation_p.S353F|HPS5_ENST00000531848.1_Missense_Mutation_p.S239F	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	353						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						AGATATCAGGGAGAGATGTGA	0.458000									Hermansky-Pudlak syndrome				34	98					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49357515	49357515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49357515G>A	ENST00000263265.6	-	10	1609	c.1054C>T	c.(1054-1056)Cct>Tct	p.P352S	PLEKHA4_ENST00000355496.5_Missense_Mutation_p.P327S	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	352	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		TCCAGGGGAGGACCCGGCTGA	0.498000													46	97					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28620128	28620128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28620128C>T	ENST00000395609.1	-	4	807	c.49G>A	c.(49-51)Ggg>Agg	p.G17R	SULT1A1_ENST00000350842.4_Intron|SULT1A1_ENST00000395607.1_Missense_Mutation_p.G17R|SULT1A1_ENST00000569554.1_Missense_Mutation_p.G17R|SULT1A1_ENST00000314752.7_Missense_Mutation_p.G17R			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	17					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						AGCGGGACCCCCTTCACGTAC	0.637000													11	78					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087069	92087069	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92087069C>T	ENST00000298047.6	+	1	1808	c.1791C>T	c.(1789-1791)atC>atT	p.I597I	FAT3_ENST00000525166.1_Silent_p.I447I|FAT3_ENST00000409404.2_Silent_p.I597I|FAT3_ENST00000541502.1_Silent_p.I597I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	597	Cadherin 6.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGTCACATCACAGCAGTCT	0.393000										TCGA Ovarian(4;0.039)			16	32					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5664531	5664531	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5664531G>A	ENST00000354852.5	+	14	2294	c.2121G>A	c.(2119-2121)gtG>gtA	p.V707V	TRIM34_ENST00000495668.1_3'UTR|HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000514226.1_Silent_p.V353V|TRIM6-TRIM34_ENST00000457787.2_Silent_p.V353V|TRIM34_ENST00000429814.2_Silent_p.V353V	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		707						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		ACTGGGAAGTGGACGTGTCCA	0.418000													18	51					0	0	1	0	0
C1orf65	164127	broad.mit.edu	37	1	223567374	223567374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:223567374C>T	ENST00000366875.3	+	1	660	c.557C>T	c.(556-558)tCc>tTc	p.S186F		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	186										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		TGGTCCCCTTCCTCAGTTCCC	0.607000													29	53					0	0	1	0	0
C2orf42	54980	broad.mit.edu	37	2	70402845	70402845	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70402845G>A	ENST00000264434.2	-	5	1378	c.999C>T	c.(997-999)ggC>ggT	p.G333G	C2orf42_ENST00000420306.1_Silent_p.G333G	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	333										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						GCTTTTTCAGGCCACTTTTCC	0.433000													96	254					0	0	1	0	0
CASP14	23581	broad.mit.edu	37	19	15166852	15166852	+	Silent	SNP	G	G	A	rs61750056	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15166852G>A	ENST00000427043.3	+	7	989	c.681G>A	c.(679-681)acG>acA	p.T227T	CASP14_ENST00000221740.1_Silent_p.T227T	NM_012114.2	NP_036246.1	P31944	CASPE_HUMAN	caspase 14, apoptosis-related cysteine peptidase	227					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(3)	26						CAAGGAAAACGAACCCTGAAA	0.522000													4	14					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187618	123187618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123187618C>T	ENST00000328880.5	-	1	272	c.213G>A	c.(211-213)gtG>gtA	p.V71V	RP11-324E6.6_ENST00000543611.1_lincRNA|HCAR1_ENST00000356987.2_Intron	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	71					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	GAAAGTCAGCCACTGCCAGGT	0.527000													21	41					0	0	1	0	0
ANKRD2	26287	broad.mit.edu	37	10	99343372	99343372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:99343372G>A	ENST00000307518.5	+	9	1240	c.973G>A	c.(973-975)Gct>Act	p.A325T	ANKRD2_ENST00000455090.1_Missense_Mutation_p.A265T|ANKRD2_ENST00000370655.1_Missense_Mutation_p.A298T|ANKRD2_ENST00000298808.5_Missense_Mutation_p.A292T			Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 (stretch responsive muscle)	325					muscle contraction|muscle organ development		structural constituent of muscle			breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		GCTCTGGCAGGCTGATACCCG	0.647000													8	14					0	0	1	0	0
ACSBG2	81616	broad.mit.edu	37	19	6187365	6187365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6187365C>T	ENST00000588304.1	+	12	1908	c.1462C>T	c.(1462-1464)Ccc>Tcc	p.P488S	ACSBG2_ENST00000588485.1_Missense_Mutation_p.P351S|ACSBG2_ENST00000591741.1_3'UTR|ACSBG2_ENST00000252669.5_Missense_Mutation_p.P538S|ACSBG2_ENST00000586696.1_Missense_Mutation_p.P538S|ACSBG2_ENST00000591403.1_Missense_Mutation_p.P538S			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	538					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAAGAAGATCCCCATCATCAG	0.468000													45	114					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477498	128477498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128477498G>A	ENST00000322313.4	-	16	2259	c.2101C>T	c.(2101-2103)Cct>Tct	p.P701S		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	701	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TGACCTTGAGGACCAGAACTA	0.642000													15	81					0	0	1	0	0
SLC22A20	440044	broad.mit.edu	37	11	64981483	64981483	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64981483C>T	ENST00000525437.1	+	0	173							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						GCCGCTGTCCCCCCCCACCAC	0.692000													5	12					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3639790	3639790	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3639790G>A	ENST00000294008.3	-	12	4489	c.3849C>T	c.(3847-3849)gcC>gcT	p.A1283A		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1283	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CCGCCTGCACGGCCAGCCCGC	0.632000								Direct reversal of damage					41	81					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121932424	121932424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:121932424G>A	ENST00000377069.4	-	12	2005	c.1599C>T	c.(1597-1599)atC>atT	p.I533I	KDM2B_ENST00000536437.1_Silent_p.I447I|KDM2B_ENST00000377071.4_Silent_p.I564I|KDM2B_ENST00000542973.1_5'UTR|KDM2B_ENST00000538046.2_Silent_p.I474I	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	564					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GGACCCCAGTGATGGCCAGAC	0.587000											OREG0022202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	29					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635402	33635402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:33635402C>T	ENST00000380099.3	+	4	2194	c.2186C>T	c.(2185-2187)gCc>gTc	p.A729V	KL_ENST00000426690.2_3'UTR|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	729	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ATATCCATAGCCTTGCAGGCT	0.493000													6	62					0	0	1	0	0
SBK1	388228	broad.mit.edu	37	16	28328886	28328886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:28328886G>A	ENST00000341901.4	+	2	963	c.174G>A	c.(172-174)gaG>gaA	p.E58E		NM_001024401.2	NP_001019572.1	Q52WX2	SBK1_HUMAN	SH3 domain binding kinase 1	58	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			kidney(1)|lung(3)|ovary(1)	5						TAGTCCGGGAGCTGGGCAAAG	0.627000											OREG0023701	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	55					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152507129	152507129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152507129C>T	ENST00000427231.2	-	53	7388	c.7186G>A	c.(7186-7188)Gat>Aat	p.D2396N	NEB_ENST00000604864.1_Missense_Mutation_p.D2396N|NEB_ENST00000603639.1_Missense_Mutation_p.D2396N|NEB_ENST00000172853.10_Missense_Mutation_p.D2396N|NEB_ENST00000397345.3_Missense_Mutation_p.D2396N|NEB_ENST00000409198.1_Missense_Mutation_p.D2396N	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2396					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGCACAACATCGTTCTGATCA	0.388000													67	172					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36778896	36778896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36778896C>T	ENST00000416516.2	-	2	1745	c.1255G>A	c.(1255-1257)Gaa>Aaa	p.E419K		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	419	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TCGTAGACTTCATGCAATTTC	0.493000													15	59					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18893760	18893760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18893760C>T	ENST00000542601.2	-	18	2529	c.2140G>A	c.(2140-2142)Gag>Aag	p.E714K	COMP_ENST00000425807.1_Missense_Mutation_p.E694K|COMP_ENST00000222271.2_Missense_Mutation_p.E747K			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	747	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						TCATAGTCCTCTGGGATGGTG	0.697000													19	83					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153054170	153054170	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153054170G>A	ENST00000285900.5	+	6	1153	c.810G>A	c.(808-810)tgG>tgA	p.W270*	GRIA1_ENST00000518142.1_Nonsense_Mutation_p.W190*|GRIA1_ENST00000518783.1_Nonsense_Mutation_p.W280*|GRIA1_ENST00000521843.2_Nonsense_Mutation_p.W201*|GRIA1_ENST00000448073.4_Nonsense_Mutation_p.W280*|GRIA1_ENST00000340592.5_Nonsense_Mutation_p.W270*	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	270					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGCAGCAGTGGAAGAATAGTG	0.532000													43	97					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154284151	154284151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154284151G>A	ENST00000285873.7	-	18	2623	c.2548C>T	c.(2548-2550)Ccc>Tcc	p.P850S		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	850					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTACTCAGGGGAAGCAAGGAA	0.403000													34	81					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30992021	30992021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30992021G>A	ENST00000383096.3	-	3	214	c.32C>T	c.(31-33)tCc>tTc	p.S11F	CCDC178_ENST00000406524.2_Missense_Mutation_p.S11F|CCDC178_ENST00000300227.8_Missense_Mutation_p.S11F|CCDC178_ENST00000579947.1_Missense_Mutation_p.S11F|CCDC178_ENST00000402325.1_Missense_Mutation_p.S11F|CCDC178_ENST00000583930.1_Missense_Mutation_p.S11F|CCDC178_ENST00000403303.1_Missense_Mutation_p.S11F|CCDC178_ENST00000579916.1_Missense_Mutation_p.S11F					coiled-coil domain containing 178																		ATCTCTAGTGGAAGAAGAGGA	0.254000													15	48					0	0	1	0	0
TTC23	64927	broad.mit.edu	37	15	99759112	99759112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:99759112G>A	ENST00000394132.2	-	7	1263	c.446C>T	c.(445-447)tCc>tTc	p.S149F	TTC23_ENST00000394130.1_Missense_Mutation_p.S149F|TTC23_ENST00000394136.1_Missense_Mutation_p.S149F|TTC23_ENST00000558663.1_Missense_Mutation_p.S149F|TTC23_ENST00000558613.1_Missense_Mutation_p.S149F|TTC23_ENST00000394129.2_Missense_Mutation_p.S149F|TTC23_ENST00000394135.3_Missense_Mutation_p.S149F|TTC23_ENST00000262074.4_Missense_Mutation_p.S149F			Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	149							binding			endometrium(2)|large_intestine(3)|lung(9)|urinary_tract(2)	16	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			CTTTTGAAGGGAGAGTAAAGC	0.393000													79	105					0	0	1	0	0
TTC39B	158219	broad.mit.edu	37	9	15185362	15185362	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:15185362G>A	ENST00000355694.2	-	16	1566	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	TTC39B_ENST00000297615.5_Silent_p.I441I|TTC39B_ENST00000380850.4_Silent_p.I497I|TTC39B_ENST00000512701.1_Silent_p.I510I|TTC39B_ENST00000507993.1_Silent_p.I345I|TTC39B_ENST00000507285.1_Silent_p.I345I	NM_001168339.1|NM_152574.2	NP_001161811.1|NP_689787.2	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	444							binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)	21						TCTCAGTAGGGATAGATTTCC	0.502000													34	73					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60359415	60359415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60359415G>A	ENST00000371204.3	-	9	1460	c.1417C>T	c.(1417-1419)Ccc>Tcc	p.P473S	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	473					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					TTGTTTGGGGGCCTGAAGGTA	0.463000													121	309					0	0	1	0	0
CYP21A2	1589	broad.mit.edu	37	6	32008204	32008204	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32008204G>A	ENST00000418967.2	+	8	1119	c.961G>A	c.(961-963)Gag>Aag	p.E321K	CYP21A2_ENST00000435122.2_Missense_Mutation_p.E291K	NM_000500.7	NP_000491.4	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A, polypeptide 2	320					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	11						ACTGCAGGAGGAGCTAGACCA	0.662000													13	38					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7623214	7623214	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7623214G>T	ENST00000572933.1	+	2	1622	c.162G>T	c.(160-162)gaG>gaT	p.E54D	DNAH2_ENST00000570791.1_Missense_Mutation_p.E54D|DNAH2_ENST00000389173.2_Missense_Mutation_p.E54D|DNAH2_ENST00000082259.3_Missense_Mutation_p.E54D			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	54	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCAAGGAGGAGCCTGGTGGGT	0.647000													5	6					3.59834e-05	3.60464e-05	1	1	0
NDUFS4	4724	broad.mit.edu	37	5	52978999	52978999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52978999C>T	ENST00000296684.5	+	5	504	c.476C>T	c.(475-477)tCt>tTt	p.S159F		NM_002495.2	NP_002486.1	O43181	NDUS4_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	159					brain development|cAMP-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|positive regulation of fibroblast proliferation|reactive oxygen species metabolic process|regulation of protein phosphorylation|response to cAMP|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(3)	10		Lung NSC(810;8.27e-05)|Breast(144;0.0848)			NADH(DB00157)	AAGTCCAAGTCTTATGGTGCA	0.393000													30	133					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65083039	65083039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:65083039G>A	ENST00000358691.5	-	32	5566	c.5400C>T	c.(5398-5400)tcC>tcT	p.S1800S	HELZ_ENST00000580168.1_Silent_p.S1801S	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGGACTCCGGGGATGAAAAGT	0.468000													52	112					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64639830	64639830	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:64639830C>T	ENST00000587624.1	+	0	713																											CTAACAACATCACCCTCCGAG	0.473000													14	96					0	0	1	0	0
TTC12	54970	broad.mit.edu	37	11	113234613	113234613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113234613C>T	ENST00000393020.1	+	20	2185	c.1780C>T	c.(1780-1782)Cat>Tat	p.H594Y	TTC12_ENST00000483239.2_Missense_Mutation_p.H600Y|TTC12_ENST00000529221.1_Missense_Mutation_p.H594Y|TTC12_ENST00000314756.3_Missense_Mutation_p.H594Y			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	594							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		GAATAGTTATCATGAAGCTCG	0.388000													18	46					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126004086	126004086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:126004086C>T	ENST00000299308.3	+	4	1201	c.1193C>T	c.(1192-1194)cCg>cTg	p.P398L		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	398						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTGGAGTACCCGATTGAGGAC	0.532000													21	80					0	0	1	0	0
LRRC4	64101	broad.mit.edu	37	7	127668746	127668746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127668746C>T	ENST00000249363.3	-	2	2205	c.1948G>A	c.(1948-1950)Gaa>Aaa	p.E650K	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	650						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		ATTTGAGTTTCCTGTACCTTG	0.438000													35	89					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127474324	127474324	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127474324C>T	ENST00000262461.2	+	8	1633	c.1444C>T	c.(1444-1446)Cga>Tga	p.R482*	SLC12A2_ENST00000343225.4_Nonsense_Mutation_p.R482*	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	482					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCCCGATTTTCGAGAGGAAGA	0.373000													21	129					0	0	1	0	0
VTCN1	79679	broad.mit.edu	37	1	117699466	117699466	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:117699466C>T	ENST00000369458.3	-	3	253	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	VTCN1_ENST00000328189.3_Intron|VTCN1_ENST00000463461.1_5'UTR|VTCN1_ENST00000539893.1_5'UTR|VTCN1_ENST00000359008.4_Missense_Mutation_p.E62K	NM_024626.3	NP_078902.2	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation inhibitor 1	59	Ig-like V-type 1.					integral to membrane|plasma membrane				large_intestine(7)|lung(4)|upper_aerodigestive_tract(1)	12	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		ATGTCAGGTTCAAAAGTGCAG	0.478000													22	81					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214805	161214805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:161214805C>T	ENST00000327928.4	+	1	210	c.210C>T	c.(208-210)acC>acT	p.T70T		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	70						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AACCAATTACCAAACCCTCGG	0.458000													16	136					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870878	13870878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13870878C>T	ENST00000265104.4	-	24	3936	c.3832G>A	c.(3832-3834)Gag>Aag	p.E1278K	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1278	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTAGTTACCTCAATAGGTCCT	0.373000									Kartagener syndrome				12	54					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180365995	180365995	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:180365995C>T	ENST00000273654.4	-	16	2191	c.1572G>A	c.(1570-1572)ctG>ctA	p.L524L	CCDC39_ENST00000442201.2_Silent_p.L440L			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	440					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTTCAAAATCCAGTTTTTGTA	0.343000													13	46					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49557646	49557646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49557646G>A	ENST00000561648.1	-	7	3767	c.3714C>T	c.(3712-3714)ttC>ttT	p.F1238F	ZNF423_ENST00000562871.1_Silent_p.F1178F|ZNF423_ENST00000535559.1_Silent_p.F1121F|ZNF423_ENST00000567169.1_Silent_p.F1121F|ZNF423_ENST00000562520.1_Silent_p.F1178F|ZNF423_ENST00000563137.2_Silent_p.F1178F|ZNF423_ENST00000262383.2_Silent_p.F1238F	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1238					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TGGCCTGGACGAAGACTAGAC	0.587000													10	32					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24653942	24653942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24653942G>A	ENST00000354464.6	-	16	1726	c.1550C>T	c.(1549-1551)cCc>cTc	p.P517L	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	517					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		AGGGAAGTAGGGCAGCAGCGA	0.612000													11	18					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53515147	53515147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53515147G>A	ENST00000301466.3	+	12	1258	c.1198G>A	c.(1198-1200)Gac>Aac	p.D400N		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	400					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						GGTGGTCCATGACTGGCTGTA	0.567000													7	72					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785631	22785631	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22785631G>A	ENST00000600260.1	+	0	1638					NR_033899.1																						CAGCGCTGAAGGAGCAGCACC	0.667000													10	17					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122536928	122536928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:122536928G>A	ENST00000264357.5	+	8	1456	c.1164G>A	c.(1162-1164)atG>atA	p.M388I	GRIA3_ENST00000542149.1_Missense_Mutation_p.M388I|GRIA3_ENST00000371256.5_Missense_Mutation_p.M388I|GRIA3_ENST00000371251.1_Missense_Mutation_p.M388I|GRIA3_ENST00000541091.1_Missense_Mutation_p.M372I	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	388					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TGTATGAAATGAAAGTCAGTG	0.348000													60	57					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46244856	46244856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46244856G>A	ENST00000296140.3	-	2	1074	c.949C>T	c.(949-951)Cac>Tac	p.H317Y	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	317					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		ACACGCCTGTGGAACAACTGC	0.592000													18	33					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155203214	155203214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155203214G>A	ENST00000460012.1	-	22	3172	c.2815C>T	c.(2815-2817)Ctt>Ttt	p.L939F	PLCH1_ENST00000414191.1_Missense_Mutation_p.L939F|PLCH1_ENST00000340059.7_Missense_Mutation_p.L977F|PLCH1_ENST00000334686.6_Missense_Mutation_p.L939F|PLCH1_ENST00000447496.2_Missense_Mutation_p.L977F|PLCH1_ENST00000494598.1_Missense_Mutation_p.L957F			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	977					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GCTCCCAGAAGGTTTCTGTCA	0.468000													35	103					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519690	113519690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113519690C>T	ENST00000284601.3	-	4	1525	c.1457G>A	c.(1456-1458)cGa>cAa	p.R486Q		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	486					glycogen metabolic process	integral to membrane		p.R486Q(2)		NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GAAATCTCTTCGTAAACATCC	0.363000													11	52					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57868667	57868667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57868667C>T	ENST00000393797.2	-	16	2104	c.1912G>A	c.(1912-1914)Gat>Aat	p.D638N	ARHGAP9_ENST00000550288.1_Missense_Mutation_p.D627N|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.D548N|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.D364N|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.D548N|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.D567N			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	567	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			CCTCTTTTATCCACAGCAGCA	0.532000													16	65					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46376127	46376127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:46376127C>T	ENST00000302177.2	+	2	1061	c.864C>T	c.(862-864)ctC>ctT	p.L288L		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	288					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		GCCTGGAGCTCCCAGGGGAGC	0.607000													22	37					0	0	1	0	0
C1QTNF9B	387911	broad.mit.edu	37	13	24465965	24465965	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:24465965G>A	ENST00000382137.3	-	3	533	c.465C>T	c.(463-465)ggC>ggT	p.G155G	C1QTNF9B_ENST00000556521.1_Intron|C1QTNF9B_ENST00000382057.3_Intron|C1QTNF9B-AS1_ENST00000417034.1_RNA|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B_ENST00000382145.1_Intron|C1QTNF9B-AS1_ENST00000382133.4_RNA|C1QTNF9B_ENST00000382140.2_Silent_p.G155G	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	155	Collagen-like 3.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						TTCCAATAGGGCCCATGGGGC	0.632000													4	55					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37514853	37514853	+	Missense_Mutation	SNP	C	C	T	rs143674262		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37514853C>T	ENST00000264741.5	+	3	578	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	ITGA9_ENST00000422441.1_Missense_Mutation_p.R108W	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	108					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		AGGGAAGAATCGGGGCACGTC	0.582000													8	45					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42306227	42306227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:42306227C>T	ENST00000379310.3	-	22	2559	c.2491G>A	c.(2491-2493)Gac>Aac	p.D831N	VWA8_ENST00000281496.6_Missense_Mutation_p.D831N	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		AAAGGTGAGTCTTCATATACA	0.343000													15	53					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72049968	72049968	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:72049968C>T	ENST00000305425.4	-	9	2312	c.1890G>A	c.(1888-1890)aaG>aaA	p.K630K	DACH1_ENST00000359684.2_Silent_p.K682K|DACH1_ENST00000313174.7_Silent_p.K482K|DACH1_ENST00000354591.4_Silent_p.K428K	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	680	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TCTTTAGCCTCTTTTGAACTA	0.333000													26	133					0	0	1	0	0
C4orf33	132321	broad.mit.edu	37	4	130023819	130023819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:130023819C>T	ENST00000281146.4	+	2	775	c.54C>T	c.(52-54)ccC>ccT	p.P18P	C4orf33_ENST00000425929.1_Silent_p.P18P|C4orf33_ENST00000502887.1_Silent_p.P18P	NM_173487.2	NP_775758.2	Q8N1A6	CD033_HUMAN	chromosome 4 open reading frame 33	18										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	10						AGCATGAGCCCGTATTTATCA	0.403000													27	78					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307828	140307828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140307828G>A	ENST00000253807.2	+	1	1351	c.1351G>A	c.(1351-1353)Gaa>Aaa	p.E451K	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.E451K|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCCCAGCAGGAACTTTTCGT	0.527000													53	95					0	0	1	0	0
FAM83A	84985	broad.mit.edu	37	8	124206289	124206289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124206289G>A	ENST00000518448.1	+	4	2688	c.674G>A	c.(673-675)gGa>gAa	p.G225E	FAM83A_ENST00000318462.6_Missense_Mutation_p.G225E|FAM83A_ENST00000276699.6_Missense_Mutation_p.G225E|FAM83A_ENST00000546351.1_Missense_Mutation_p.G169E|FAM83A_ENST00000536633.1_Missense_Mutation_p.G225E|FAM83A_ENST00000522648.1_Missense_Mutation_p.G169E			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	225										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AGTGTGGAAGGAGAGATATAC	0.463000													7	48					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294075	124294075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124294075C>T	ENST00000356130.3	-	1	714	c.693G>A	c.(691-693)gaG>gaA	p.E231E		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGGATCTGCCCTCTGCAGAAG	0.438000													6	55					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43804268	43804268	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43804268G>A	ENST00000403856.1	-	11	1077	c.930C>T	c.(928-930)ctC>ctT	p.L310L	THADA_ENST00000404790.1_Silent_p.L310L|THADA_ENST00000402360.2_Silent_p.L310L|THADA_ENST00000330266.7_Silent_p.L20L|THADA_ENST00000415080.2_Silent_p.L20L|THADA_ENST00000405006.4_Silent_p.L310L|THADA_ENST00000405975.2_Silent_p.L310L			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	310							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TCCCCTGACAGAGGAATAAGA	0.542000											OREG0014580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	21					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27493257	27493257	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:27493257G>A	ENST00000527372.1	-	2	882	c.702C>T	c.(700-702)tcC>tcT	p.S234S	MYO18A_ENST00000531253.1_Silent_p.S234S|MYO18A_ENST00000533112.1_Silent_p.S234S|MYO18A_ENST00000354329.4_Silent_p.S234S	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	234	PDZ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TGCGCCGCAGGGAGAAGCCAA	0.701000													30	44					0	0	1	0	0
ZFP2	80108	broad.mit.edu	37	5	178358763	178358763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178358763G>A	ENST00000361362.2	+	5	979	c.449G>A	c.(448-450)aGa>aAa	p.R150K	ZFP2_ENST00000503510.2_Missense_Mutation_p.R150K|ZFP2_ENST00000520301.1_Missense_Mutation_p.R150K|ZFP2_ENST00000523286.1_Missense_Mutation_p.R150K	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R150I(2)		NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GTACATCAAAGAATTCATACT	0.413000													26	57					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176304662	176304662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176304662G>A	ENST00000329542.4	+	10	1867	c.1593G>A	c.(1591-1593)tgG>tgA	p.W531*	UNC5A_ENST00000261961.3_Nonsense_Mutation_p.W491*	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	531	ZU5.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGACAGCTGGAGCCTGCGCC	0.647000													11	37					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7649458	7649458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7649458C>T	ENST00000359156.4	-	5	1252	c.1050G>A	c.(1048-1050)tgG>tgA	p.W350*	CD163_ENST00000541972.1_Nonsense_Mutation_p.W338*|CD163_ENST00000396620.3_Nonsense_Mutation_p.W350*|CD163_ENST00000432237.2_Nonsense_Mutation_p.W350*	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	350	SRCR 3.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AATGCTTTCCCCATTCATGGT	0.423000													15	57					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142641786	142641786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142641786G>A	ENST00000355265.2	-	12	1831	c.1357C>T	c.(1357-1359)Cgc>Tgc	p.R453C		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	453					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TTTCTGAGGCGAGTGATGAGG	0.607000													4	52					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14284333	14284333	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:14284333G>A	ENST00000310358.7	+	0	2607							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		CACGTGATTCGAACCCGGATG	0.537000													4	27					0	0	1	0	0
GSTM3	2947	broad.mit.edu	37	1	110280755	110280755	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110280755A>T	ENST00000540225.1	-	6	640	c.330T>A	c.(328-330)gaT>gaA	p.D110E	GSTM3_ENST00000256594.3_Missense_Mutation_p.D110E|GSTM3_ENST00000488824.1_5'UTR|GSTM3_ENST00000361066.2_Missense_Mutation_p.D110E|RP4-735C1.4_ENST00000431955.1_RNA			P21266	GSTM3_HUMAN	glutathione S-transferase mu 3 (brain)	110	GST C-terminal.				establishment of blood-nerve barrier|glutathione metabolic process|response to estrogen stimulus	cytoplasm	glutathione transferase activity|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|skin(1)	9		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Colorectal(144;0.0339)|Lung(183;0.0426)|all cancers(265;0.113)|Epithelial(280;0.125)|COAD - Colon adenocarcinoma(174;0.134)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	GTGTGCGGAAATCCATTACTT	0.443000													21	43					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40853444	40853444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:40853444C>T	ENST00000254691.5	+	3	2209	c.2010C>T	c.(2008-2010)tcC>tcT	p.S670S	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	670					apoptosis|regulation of apoptosis	intracellular		p.S670S(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TTCAAGTTTCCTCTGGAGAAA	0.493000													53	131					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996416	140996416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140996416C>T	ENST00000285879.4	+	4	3512	c.3226C>T	c.(3226-3228)Cat>Tat	p.H1076Y	MAGEC1_ENST00000406005.2_Missense_Mutation_p.H143Y	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1076	MAGE.						protein binding	p.H1076Y(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAAGAGCTCATTCAGAAGT	0.458000										HNSCC(15;0.026)			24	129					0	0	1	0	0
C1orf194	127003	broad.mit.edu	37	1	109649166	109649166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109649166C>T	ENST00000369949.4	-	4	573	c.394G>A	c.(394-396)Gga>Aga	p.G132R	C1orf194_ENST00000369948.3_Missense_Mutation_p.G144R|C1orf194_ENST00000369945.3_Missense_Mutation_p.G105R	NM_001122961.1	NP_001116433.1	Q5T5A4	CA194_HUMAN	chromosome 1 open reading frame 194	144										large_intestine(2)|lung(2)|ovary(2)	6						CCTATGGATCCTTGGATGCTG	0.493000													104	278					0	0	1	0	0
NXF2B	728343	broad.mit.edu	37	X	101620165	101620165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:101620165G>A	ENST00000457521.2	-	27	3152	c.1281C>T	c.(1279-1281)ttC>ttT	p.F427F	NXF2B_ENST00000372752.1_Silent_p.F339F|NXF2B_ENST00000372750.1_Silent_p.F427F|NXF2B_ENST00000489531.1_5'UTR|NXF2B_ENST00000372749.1_Silent_p.F427F|NXF2B_ENST00000412230.2_Silent_p.F427F					nuclear RNA export factor 2B											breast(1)|kidney(1)|lung(4)|ovary(1)	7						CCTTGGGGTCGAAGGGAATAG	0.572000													19	56					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19105985	19105985	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19105985G>A	ENST00000601879.1	-	9	3393	c.3096C>T	c.(3094-3096)tcC>tcT	p.S1032S	SUGP2_ENST00000600377.1_Silent_p.S1046S|SUGP2_ENST00000456085.2_Silent_p.S801S|SUGP2_ENST00000452918.2_Silent_p.S1032S|SUGP2_ENST00000337018.6_Silent_p.S1032S			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	1032	G-patch.				mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CCTTTCCGAGGGAGCCCAGGC	0.642000													13	36					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49667581	49667581	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49667581C>T	ENST00000339139.4	-	6	443	c.207G>A	c.(205-207)acG>acA	p.T69T		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	69						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTTGGGCATTCGTTGTTACCT	0.343000													26	41					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785278	22785278	+	RNA	SNP	G	G	A	rs141007327	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22785278G>A	ENST00000600260.1	+	0	1454					NR_033899.1																						TGTGTGGGGGGACCCACCGGG	0.662000													7	15					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106602608	106602608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106602608C>T	ENST00000369701.3	+	2	913	c.686C>T	c.(685-687)tCa>tTa	p.S229L		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	229						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACTGAGAGTTCACTATGGAGG	0.502000													15	57					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164507068	164507068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164507068C>T	ENST00000503008.1	-	6	1232	c.256G>A	c.(256-258)Gaa>Aaa	p.E86K	MARCH1_ENST00000274056.7_Missense_Mutation_p.E86K|MARCH1_ENST00000514618.1_Missense_Mutation_p.E342K|MARCH1_ENST00000339875.5_Missense_Mutation_p.E69K	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	86					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCATCCCCTTCGCAGTGACAG	0.527000													19	27					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169394081	169394081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169394081C>T	ENST00000545005.1	-	3	592	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	CCDC181_ENST00000367805.3_Missense_Mutation_p.E29K|CCDC181_ENST00000491570.1_5'UTR|CCDC181_ENST00000367806.3_Missense_Mutation_p.E29K					coiled-coil domain containing 181																		TTTTCATTTTCATTAATTAAC	0.299000													19	84					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923706	24923706	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24923706C>T	ENST00000329468.2	+	1	3166	c.2692C>T	c.(2692-2694)Cat>Tat	p.H898Y		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ATCCATCTCTCATTCCACACT	0.502000													52	149					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784959	9784959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9784959C>T	ENST00000304374.2	+	1	1702	c.1306C>T	c.(1306-1308)Cgc>Tgc	p.R436C		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	436					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.R436S(1)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TCCTTTCGATCGCATGTTCCA	0.557000													28	73					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57734081	57734081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57734081C>T	ENST00000360716.3	+	5	624	c.403C>T	c.(403-405)Ccc>Tcc	p.P135S	CCDC135_ENST00000394337.4_Missense_Mutation_p.P135S|RP11-405F3.4_ENST00000563062.1_RNA|CCDC135_ENST00000336825.8_Missense_Mutation_p.P135S			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	135						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						AACCCTCCGGCCCACACTGAT	0.572000													69	151					0	0	1	0	0
TRAF1	7185	broad.mit.edu	37	9	123667431	123667431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:123667431C>T	ENST00000373887.3	-	8	3563	c.1118G>A	c.(1117-1119)aGg>aAg	p.R373K	TRAF1_ENST00000540010.1_Missense_Mutation_p.R373K|TRAF1_ENST00000546084.1_Missense_Mutation_p.R251K	NM_005658.4	NP_005649.1	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	373	MATH.				apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(4)|pancreas(1)|skin(2)	22						ACTCTGGGGCCTCTGGAAGGA	0.587000													13	24					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125435305	125435305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125435305G>A	ENST00000308736.2	-	22	3012	c.2914C>T	c.(2914-2916)Ctt>Ttt	p.L972F	DHX37_ENST00000544745.1_Missense_Mutation_p.L759F	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	972							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TCTTTGAAAAGGACGGAGCTG	0.582000													24	54					0	0	1	0	0
HOXA6	3203	broad.mit.edu	37	7	27187241	27187241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27187241C>T	ENST00000222728.3	-	1	152	c.128G>A	c.(127-129)gGg>gAg	p.G43E	HOXA-AS3_ENST00000521231.1_RNA|HOXA3_ENST00000467897.2_Intron|HOXA-AS3_ENST00000521197.1_RNA|HOXA-AS3_ENST00000518848.1_RNA|HOXA-AS3_ENST00000518947.2_RNA|HOXA6_ENST00000521478.1_Intron	NM_024014.3	NP_076919.1	P31267	HXA6_HUMAN	homeobox A6	43						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|lung(3)|ovary(1)	10						ACTCGACGCCCCGTACGAGGC	0.657000													19	41					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34611583	34611583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34611583G>A	ENST00000373973.3	+	11	1502	c.1329G>A	c.(1327-1329)atG>atA	p.M443I	CNBD2_ENST00000349339.1_Missense_Mutation_p.M439I|CNBD2_ENST00000538900.1_Intron					cyclic nucleotide binding domain containing 2																		TGATCCTGATGAGCCTGGGAA	0.443000													32	104					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4201420	4201420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4201420C>T	ENST00000404826.2	+	32	4871	c.4732C>T	c.(4732-4734)Cca>Tca	p.P1578S	SDK1_ENST00000389531.3_Missense_Mutation_p.P1578S	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1578	Fibronectin type-III 10.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGTTTCAGTTCCAGGAGAGCC	0.607000													31	140					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628328	173628328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173628328C>T	ENST00000333279.2	-	2	290	c.230G>A	c.(229-231)gGg>gAg	p.G77E		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	93										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						CAAATTTCTCCCAACGATGTC	0.443000													42	110					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173503725	173503725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173503725C>T	ENST00000367714.3	-	16	2294	c.1872G>A	c.(1870-1872)atG>atA	p.M624I	SLC9C2_ENST00000466087.1_5'UTR|SLC9C2_ENST00000536496.1_Intron	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	624					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										GATGTATTATCATAGGATAAA	0.259000													8	79					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10545925	10545925	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10545925T>C	ENST00000583535.1	-	16	1784	c.1697A>G	c.(1696-1698)aAg>aGg	p.K566R	MYH3_ENST00000226209.7_Missense_Mutation_p.K566R	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	566	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CACCTTGGGCTTCTGGAAGTT	0.532000													59	81					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219249050	219249050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219249050G>A	ENST00000233202.6	+	3	575	c.235G>A	c.(235-237)Gag>Aag	p.E79K	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	79	Pro/Ser-rich.				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGAAACATCGAGTCAGATCT	0.587000													48	140					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79458278	79458278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:79458278G>A	ENST00000264895.6	+	72	11662	c.11222G>A	c.(11221-11223)gGg>gAg	p.G3741E		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3736					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GATCCCACGGGGACAATCTAC	0.423000													33	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077159	9077159	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9077159C>T	ENST00000397910.4	-	3	10490	c.10287G>A	c.(10285-10287)tgG>tgA	p.W3429*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3430	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGATCTGACCAAGAACTAG	0.458000													52	103					0	0	1	0	0
PVRL2	5819	broad.mit.edu	37	19	45375207	45375207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45375207C>T	ENST00000252483.5	+	3	576	c.576C>T	c.(574-576)gcC>gcT	p.A192A	PVRL2_ENST00000252485.4_Silent_p.A192A	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	192	Ig-like C2-type 1.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		GCCCACCTGCCCGGATCTCCT	0.622000													14	30					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043518	117043518	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117043518G>A	ENST00000371876.1	-	4	3380	c.959C>T	c.(958-960)tCg>tTg	p.S320L	KLHL13_ENST00000262820.3_Missense_Mutation_p.S371L|KLHL13_ENST00000371878.1_Missense_Mutation_p.S320L|KLHL13_ENST00000371882.1_Missense_Mutation_p.S320L|KLHL13_ENST00000541812.1_Missense_Mutation_p.S355L|KLHL13_ENST00000545703.1_Missense_Mutation_p.S329L|KLHL13_ENST00000469946.1_Missense_Mutation_p.S320L|KLHL13_ENST00000539496.1_Missense_Mutation_p.S374L|KLHL13_ENST00000540167.1_Missense_Mutation_p.S355L			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	371					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex		p.S371L(1)		NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGGGGCTAACGATTTCCACTC	0.488000													41	30					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66937411	66937411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:66937411C>T	ENST00000374690.3	+	5	2789	c.2265C>T	c.(2263-2265)ttC>ttT	p.F755F	AR_ENST00000396044.3_Intron|AR_ENST00000396043.2_Silent_p.F223F	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	754	Interaction with MYST2.|Ligand-binding.		T -> A (in prostate cancer).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GGCGATCCTTCACCAATGTCA	0.537000									Androgen Insensitivity Syndrome				23	15					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215259778	215259778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:215259778C>T	ENST00000444842.2	+	2	264	c.114C>T	c.(112-114)tcC>tcT	p.S38S	KCNK2_ENST00000391894.2_Silent_p.S23S|KCNK2_ENST00000391895.2_Silent_p.S34S	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	38							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TCTCGTTTTCCACGAAACCCA	0.512000													18	57					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164741402	164741402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164741402G>A	ENST00000264382.3	-	26	3117	c.3055C>T	c.(3055-3057)Cgt>Tgt	p.R1019C		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1019	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACCTCCACACGAAGAGTTGAG	0.393000										HNSCC(35;0.089)			32	106					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35740337	35740337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35740337G>A	ENST00000440995.2	+	23	3283	c.3283G>A	c.(3283-3285)Gaa>Aaa	p.E1095K	SPEF2_ENST00000356031.3_Missense_Mutation_p.E1100K|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1100					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGATGATGAGGAAACAAAGGC	0.453000													56	121					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754602	76754602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76754602G>A	ENST00000536229.3	+	1	2921	c.2212G>A	c.(2212-2214)Gag>Aag	p.E738K	SALL3_ENST00000575389.2_Missense_Mutation_p.E871K|SALL3_ENST00000537592.2_Missense_Mutation_p.E871K			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	871					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CGGGTCCGGGGAGAGTGACCG	0.677000													15	63					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79834875	79834875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79834875C>T	ENST00000360280.3	+	11	1020	c.760C>T	c.(760-762)Cgt>Tgt	p.R254C	VPS13A_ENST00000376636.3_Missense_Mutation_p.R254C|VPS13A_ENST00000376634.4_Missense_Mutation_p.R254C|VPS13A_ENST00000357409.5_Missense_Mutation_p.R254C	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	254					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TTCAGTATTTCGTCCCATATC	0.323000													6	86					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166850864	166850864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166850864C>T	ENST00000423058.2	-	25	4661	c.4644G>A	c.(4642-4644)atG>atA	p.M1548I	SCN1A_ENST00000409050.1_Missense_Mutation_p.M1520I|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.M1537I|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.M1548I	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1548						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGATGAGAATCATGATGCTTA	0.368000													15	41					0	0	1	0	0
OR10G9	219870	broad.mit.edu	37	11	123894517	123894517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123894517C>T	ENST00000375024.1	+	1	798	c.798C>T	c.(796-798)gtC>gtT	p.V266V		NM_001001953.1	NP_001001953.1	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G, member 9	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(33)|prostate(2)|skin(4)|stomach(8)|urinary_tract(1)	61		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCAGGGACGTCGTGGATGGAG	0.512000													59	127					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79983001	79983001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79983001C>T	ENST00000360280.3	+	62	8762	c.8502C>T	c.(8500-8502)ttC>ttT	p.F2834F	VPS13A_ENST00000376636.3_Silent_p.F2795F|VPS13A_ENST00000376634.4_Silent_p.F2834F|VPS13A_ENST00000357409.5_Silent_p.F2834F	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	2834					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ACTATCAGTTCCATACAACAT	0.328000													6	29					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33768033	33768033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33768033C>T	ENST00000285013.6	-	6	2550	c.2275G>A	c.(2275-2277)Ggg>Agg	p.G759R	SLFN13_ENST00000542635.1_Missense_Mutation_p.G759R|SLFN13_ENST00000360502.2_Missense_Mutation_p.G441R|SLFN13_ENST00000533791.1_Missense_Mutation_p.G759R|SLFN13_ENST00000534689.1_Missense_Mutation_p.G441R|SLFN13_ENST00000526861.1_Missense_Mutation_p.G759R	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	759						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCCAGATACCCATGGGGGATA	0.388000													41	64					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263555	39263555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:39263555C>T	ENST00000280481.7	+	1	2290	c.2074C>T	c.(2074-2076)Cgt>Tgt	p.R692C		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	692					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTTTGTGATTCGTATCCATCC	0.562000													32	104					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18754784	18754784	+	Missense_Mutation	SNP	C	C	T	rs139371305		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18754784C>T	ENST00000396170.1	-	11	2384	c.1120G>A	c.(1120-1122)Gag>Aag	p.E374K	PTPN5_ENST00000396171.4_Missense_Mutation_p.E406K|PTPN5_ENST00000396167.2_Missense_Mutation_p.E374K|PTPN5_ENST00000358540.2_Missense_Mutation_p.E406K|PTPN5_ENST00000477854.1_Missense_Mutation_p.E210K|RP11-1081L13.4_ENST00000527285.1_RNA|PTPN5_ENST00000396168.1_Missense_Mutation_p.E382K	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	406	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						GTCCCTACCTCGTTCATCTCC	0.517000													33	82					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110804801	110804801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110804801G>A	ENST00000375820.4	-	51	4929	c.4808C>T	c.(4807-4809)tCc>tTc	p.S1603F		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1603	Collagen IV NC1.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTCCAGGCAGGAGCCGGGGGA	0.597000													15	37					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178585872	178585872	+	Silent	SNP	G	G	A	rs149253571		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178585872G>A	ENST00000251582.7	-	6	1085	c.984C>T	c.(982-984)agC>agT	p.S328S	ADAMTS2_ENST00000274609.5_Silent_p.S328S	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	328	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TCTCGATGAGGCTCATGGACT	0.612000													8	26					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55652907	55652907	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55652907G>A	ENST00000449290.2	+	2	95	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	1						intracellular	zinc ion binding										TCAGAAACATGAATTCTGGAA	0.443000													50	170					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169146730	169146730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169146730G>A	ENST00000393743.3	-	34	4922	c.4631C>T	c.(4630-4632)tCc>tTc	p.S1544F		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1544							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AGCCAGTTTGGAAACAATTCG	0.333000													20	57					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183209732	183209732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183209732C>T	ENST00000341319.3	-	7	1884	c.1849G>A	c.(1849-1851)Gga>Aga	p.G617R		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	617										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GACACTGCTCCGGGCACGATC	0.662000													13	54					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75230628	75230628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75230628C>T	ENST00000325680.7	+	1	560	c.436C>T	c.(436-438)Ccc>Tcc	p.P146S	YLPM1_ENST00000238571.3_Missense_Mutation_p.P146S|YLPM1_ENST00000552421.1_Missense_Mutation_p.P146S	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	146	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GCTGGAATCCCCCCCTGAATC	0.612000													35	41					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46712010	46712010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:46712010C>T	ENST00000454366.1	+	7	1345	c.1133C>T	c.(1132-1134)cCc>cTc	p.P378L		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	359					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		AGAATGGGACCCGCCATGCTG	0.567000													38	48					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96312912	96312912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96312912C>T	ENST00000277165.6	+	12	2407	c.2213C>T	c.(2212-2214)gCc>gTc	p.A738V	FAM120A_ENST00000333936.5_Missense_Mutation_p.A766V|FAM120A_ENST00000340893.4_Missense_Mutation_p.A738V	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	738						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GAGCTAGATGCCTTCCTGGCT	0.557000													18	39					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169525903	169525903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169525903G>A	ENST00000367796.3	-	6	1134	c.933C>T	c.(931-933)ctC>ctT	p.L311L	F5_ENST00000546081.1_Silent_p.L174L|F5_ENST00000367797.3_Silent_p.L311L			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	311	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTTTTGGGGTGAGAGAAGATA	0.478000													6	62					0	0	1	0	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95374164	95374164	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:95374164C>T	ENST00000494840.1	-	0	1697					NR_077228.1																						GGAGTATATCCATGAGATATT	0.403000													18	43					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7675818	7675818	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:7675818G>A	ENST00000446248.2	+	10	1231		c.e10+1		CAMSAP3_ENST00000160298.4_Splice_Site	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3						epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						GCGGCAGTAGGTACGCTCCCC	0.642000													23	77					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174964	51174964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51174964G>A	ENST00000440970.1	-	2	1309	c.878C>T	c.(877-879)cCa>cTa	p.P293L	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.P390L	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	390					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			AGGTAGAAGTGGATTAGACGC	0.522000													25	70					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390319	197390319	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197390319G>A	ENST00000367400.3	+	6	1496	c.1361G>A	c.(1360-1362)gGa>gAa	p.G454E	CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000544212.1_5'UTR|CRB1_ENST00000538660.1_Missense_Mutation_p.G454E|CRB1_ENST00000367399.2_Missense_Mutation_p.G342E|CRB1_ENST00000543483.1_Missense_Mutation_p.G153E|CRB1_ENST00000535699.1_Missense_Mutation_p.G385E|CRB1_ENST00000476483.1_3'UTR	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	454	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTAAATAATGGAACATGCATC	0.468000													37	102					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187172781	187172781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187172781C>T	ENST00000264690.6	+	9	1196	c.1009C>T	c.(1009-1011)Cca>Tca	p.P337S	KLKB1_ENST00000513864.1_Missense_Mutation_p.P337S	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	337	Apple 4.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TTCTTTACTCCCAGAAGACTG	0.363000													27	80					0	0	1	0	0
WDR89	112840	broad.mit.edu	37	14	64066610	64066610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:64066610G>A	ENST00000394942.2	-	2	139	c.51C>T	c.(49-51)tcC>tcT	p.S17S	WDR89_ENST00000267522.3_Silent_p.S17S	NM_001008726.2|NM_001258272.1|NM_080666.3	NP_001008726.1|NP_001245201.1|NP_542397.1	Q96FK6	WDR89_HUMAN	WD repeat domain 89	17										endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.00543)|all cancers(60;0.0181)|BRCA - Breast invasive adenocarcinoma(234;0.101)		TGGTTCCTAAGGAACATTTAA	0.363000													8	117					0	0	1	0	0
PDK2	5164	broad.mit.edu	37	17	48187418	48187418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48187418C>T	ENST00000503176.1	+	11	1342	c.1181C>T	c.(1180-1182)cCc>cTc	p.P394L	PDK2_ENST00000007708.3_Missense_Mutation_p.P330L|SAMD14_ENST00000330175.4_3'UTR	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	394					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						TGGTGTGTGCCCAGCACGGAG	0.672000									Autosomal Dominant Polycystic Kidney Disease				4	14					0	0	1	0	0
SETD4	54093	broad.mit.edu	37	21	37412927	37412927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37412927G>A	ENST00000399215.1	-	8	2382	c.1010C>T	c.(1009-1011)cCa>cTa	p.P337L	SETD4_ENST00000481477.1_5'UTR|SETD4_ENST00000399212.1_Missense_Mutation_p.P313L|SETD4_ENST00000332131.4_Missense_Mutation_p.P337L|AP000688.1_ENST00000600312.1_Intron			Q9NVD3	SETD4_HUMAN	SET domain containing 4	337				EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRL LTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKI CYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELK ILRASAETLHSLQTAFT -> GWNQLCS (in Ref. 5; AAH02898).						autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						CCTCCAAGATGGTCCATCCCA	0.383000													64	181					0	0	1	0	0
HADHB	3032	broad.mit.edu	37	2	26486319	26486319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:26486319C>T	ENST00000317799.5	+	4	285	c.181C>T	c.(181-183)Cgc>Tgc	p.R61C	HADHB_ENST00000494615.1_3'UTR|HADHB_ENST00000545822.1_Missense_Mutation_p.R39C|HADHB_ENST00000405867.3_Missense_Mutation_p.R61C|HADHB_ENST00000537713.1_Missense_Mutation_p.R61C	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	61			R -> C (in TFP deficiency).|R -> H (in TFP deficiency).		fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGATGGTGTTCGCACTCCATT	0.348000													37	105					0	0	1	0	0
SGPP2	130367	broad.mit.edu	37	2	223386575	223386575	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:223386575G>A	ENST00000321276.7	+	3	554	c.468G>A	c.(466-468)ctG>ctA	p.L156L		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	156					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		AAAAGAGACTGATCGCTGAAT	0.522000													29	84					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106124630	106124630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106124630G>A	ENST00000369704.3	+	4	714	c.580G>A	c.(580-582)Gaa>Aaa	p.E194K	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	194										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AGAGGAGGCTGAACATGCCAT	0.488000													18	39					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182763211	182763211	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:182763211C>T	ENST00000492597.1	-	9	1448	c.746G>A	c.(745-747)tGg>tAg	p.W249*	MCCC1_ENST00000265594.4_Nonsense_Mutation_p.W358*|MCCC1_ENST00000539926.1_Nonsense_Mutation_p.W223*			Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	358	ATP-grasp.|Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	TCTAAGCTGCCACTCCACCAA	0.458000													27	82					0	0	1	0	0
TNFRSF4	7293	broad.mit.edu	37	1	1147102	1147102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1147102C>T	ENST00000379236.3	-	6	749	c.745G>A	c.(745-747)Gat>Aat	p.D249N		NM_003327.3	NP_003318.1	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily, member 4	249					immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity			large_intestine(1)|lung(2)|urinary_tract(1)	4	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTGTGGGCATCGGGGGGCAGC	0.706000													8	8					0	0	1	0	0
MAB21L3	126868	broad.mit.edu	37	1	116675774	116675774	+	Missense_Mutation	SNP	G	G	A	rs150571972		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:116675774G>A	ENST00000369500.3	+	7	1142	c.877G>A	c.(877-879)Gag>Aag	p.E293K		NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	293										breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						TTGGACCTGCGAGAAATATCC	0.478000													15	30					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205272864	205272864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205272864G>A	ENST00000367157.3	-	7	1727	c.1601C>T	c.(1600-1602)gCc>gTc	p.A534V		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	534					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCTGGCCCGGGCCAGGGGGCG	0.652000													31	55					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2898716	2898716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:2898716C>T	ENST00000254695.8	+	13	1090	c.1000C>T	c.(1000-1002)Cac>Tac	p.H334Y	RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.H319Y|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.H315Y|RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.H334Y	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	334	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GATCATGTTTCACGTTTCCAC	0.587000													62	55					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46851304	46851304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46851304C>T	ENST00000283296.7	-	6	892	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	GPR116_ENST00000456426.2_Missense_Mutation_p.E202K|GPR116_ENST00000265417.7_Missense_Mutation_p.E202K|GPR116_ENST00000362015.4_Missense_Mutation_p.E202K	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	202	SEA.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			ACCGCTGTTTCCAAGTCGGTC	0.448000													12	29					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7026910	7026910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:7026910C>T	ENST00000409757.4	+	13	2061	c.1937C>T	c.(1936-1938)cCc>cTc	p.P646L	TBC1D14_ENST00000446947.2_Missense_Mutation_p.P293L|TBC1D14_ENST00000410031.1_Missense_Mutation_p.P418L|TBC1D14_ENST00000448507.1_Missense_Mutation_p.P646L|TBC1D14_ENST00000451522.2_Missense_Mutation_p.P366L	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	646						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						ACCCGGCTGCCCGAGGACCTG	0.597000													29	55					0	0	1	0	0
SV2C	22987	broad.mit.edu	37	5	75596679	75596679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:75596679C>T	ENST00000502798.2	+	11	2204	c.1762C>T	c.(1762-1764)Ctg>Ttg	p.L588L	RP11-466P24.6_ENST00000502589.1_RNA|SV2C_ENST00000322285.7_Silent_p.L588L	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	588					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TGTCAACTTTCTGGGGACATT	0.413000													40	184					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49578756	49578756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49578756C>T	ENST00000371175.4	-	7	1074	c.1048G>A	c.(1048-1050)Gca>Aca	p.A350T	RHAG_ENST00000229810.7_Intron	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	350					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					GCGCCCATTGCTACTGCCACA	0.478000													34	58					0	0	1	0	0
LAYN	143903	broad.mit.edu	37	11	111425979	111425979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111425979G>A	ENST00000436913.2	+	4	588	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	LAYN_ENST00000533265.1_Missense_Mutation_p.E208K|LAYN_ENST00000525126.1_Missense_Mutation_p.E216K|LAYN_ENST00000375615.3_Missense_Mutation_p.E216K|LAYN_ENST00000375614.2_Missense_Mutation_p.E208K|LAYN_ENST00000528924.1_3'UTR	NM_001258391.1	NP_001245320.1	Q6UX15	LAYN_HUMAN	layilin	216	C-type lectin.					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|skin(1)	14		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		AGAAACACAGGAAGAAGATGC	0.398000													18	39					0	0	1	0	0
FABP2	2169	broad.mit.edu	37	4	120240735	120240735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:120240735C>T	ENST00000274024.3	-	3	591	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K		NM_000134.3	NP_000125.2	P12104	FABPI_HUMAN	fatty acid binding protein 2, intestinal	102							fatty acid binding	p.E102K(1)		breast(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	8						GTATTCAGTTCGTTTCCATTG	0.308000													23	53					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4544408	4544408	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4544408G>A	ENST00000586582.1	-	17	2182	c.1872C>T	c.(1870-1872)ctC>ctT	p.L624L	SEMA6B_ENST00000301293.3_Silent_p.L624L|SEMA6B_ENST00000586965.1_Intron	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	624					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGCTCACGGAGGCCCACGA	0.731000													9	20					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98288972	98288972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:98288972C>T	ENST00000322128.3	-	1	1204	c.1101G>A	c.(1099-1101)gaG>gaA	p.E367E		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	367					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CGTTGATTATCTCCACAATCT	0.463000													57	207					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64769444	64769444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:64769444C>T	ENST00000536360.1	-	2	870	c.57G>A	c.(55-57)tcG>tcA	p.S19S				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	19					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.S19S(1)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TATGAAATTCCGATGAAGCCA	0.363000													45	128					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	184002751	184002751	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184002751G>A	ENST00000402825.3	+	9	1360	c.1359_splice	c.e9-1	p.A454_splice	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000359140.4_Splice_Site_p.A307_splice|ECE2_ENST00000404464.3_Splice_Site_p.A336_splice|ECE2_ENST00000357474.5_Splice_Site_p.A382_splice	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	454	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTTCTTTCAGGCTCTGGCGCC	0.547000											OREG0015945	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	43					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44079588	44079588	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:44079588G>A	ENST00000272286.2	+	5	747	c.657G>A	c.(655-657)agG>agA	p.R219R		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	219	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GTGAGCGCAGGAGAGTCAGCA	0.677000													22	34					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136597649	136597649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136597649C>T	ENST00000371872.4	-	3	663	c.406G>A	c.(406-408)Gag>Aag	p.E136K	SARDH_ENST00000371867.1_Missense_Mutation_p.E47K|SARDH_ENST00000298628.5_Missense_Mutation_p.E136K|SARDH_ENST00000422262.2_5'UTR|SARDH_ENST00000439388.1_Missense_Mutation_p.E136K	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	136					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TCCTCCAGCTCCCGGCTCACC	0.672000													33	148					0	0	1	0	0
SFPQ	6421	broad.mit.edu	37	1	35652632	35652632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35652632G>A	ENST00000357214.5	-	9	2054	c.1956C>T	c.(1954-1956)acC>acT	p.T652T		NM_005066.2	NP_005057.1	P23246	SFPQ_HUMAN	splicing factor proline/glutamine-rich	652					alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|RNA binding		SFPQ/TFE3(6)	NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				AACCACTCATGGTTGCTGGTG	0.453000			T	TFE3	papillary renal cell								39	67					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94645345	94645345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94645345G>A	ENST00000260526.6	-	20	2598	c.2416C>T	c.(2416-2418)Ctt>Ttt	p.L806F	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	806	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TGTCTTAGAAGGTCTTTGCTT	0.289000													35	90					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124401062	124401062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124401062G>A	ENST00000409039.3	+	62	10452	c.10427G>A	c.(10426-10428)gGg>gAg	p.G3476E		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3476	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATAAAGTACGGGACCCCTTTC	0.453000													16	113					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34180240	34180240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:34180240C>T	ENST00000262622.3	+	2	831	c.73C>T	c.(73-75)Ctc>Ttc	p.L25F	CHST8_ENST00000434302.1_Missense_Mutation_p.L25F|CHST8_ENST00000604556.1_Missense_Mutation_p.L25F|CHST8_ENST00000438847.2_Missense_Mutation_p.L25F	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	25					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					AGCTGCAGGCCTCCTCCTCTT	0.637000													42	101					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104048474	104048474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104048474G>A	ENST00000388887.2	+	13	1753	c.1549G>A	c.(1549-1551)Gag>Aag	p.E517K		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	517	FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GAGCAACAATGAGGTGAGTAT	0.463000													32	86					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14160012	14160012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14160012C>T	ENST00000263379.2	+	10	1413	c.1288C>T	c.(1288-1290)Cca>Tca	p.P430S		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	430	Fibronectin type-III 3.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						AGATGCCCCTCCAGGGACCCC	0.647000											OREG0025303	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	51					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884217	228884217	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228884217G>A	ENST00000392056.3	-	7	1399	c.1353C>T	c.(1351-1353)gtC>gtT	p.V451V	SPHKAP_ENST00000344657.5_Silent_p.V451V	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	451						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTGAACAACGACGATTTTGG	0.507000													27	78					0	0	1	0	0
OXSR1	9943	broad.mit.edu	37	3	38266165	38266165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38266165C>T	ENST00000311806.3	+	8	1178	c.806C>T	c.(805-807)tCa>tTa	p.S269L	OXSR1_ENST00000446845.1_Missense_Mutation_p.S269L	NM_005109.2	NP_005100.1	O95747	OXSR1_HUMAN	oxidative stress responsive 1	269	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AAAATGATTTCATTGTGCCTT	0.313000													13	40					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12942180	12942180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12942180G>A	ENST00000235349.5	-	3	440	c.370C>T	c.(370-372)Cat>Tat	p.H124Y		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	124										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAGCACCCATGGGCCATAGCT	0.493000													86	206					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115406706	115406706	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115406706C>T	ENST00000369358.4	-	10	1213	c.969G>A	c.(967-969)aaG>aaA	p.K323K	NRAP_ENST00000360478.3_Silent_p.K323K|NRAP_ENST00000359988.3_Silent_p.K323K|NRAP_ENST00000369360.3_Silent_p.K323K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	323						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CGTGAGCTTTCTTGGCGTTCT	0.522000													34	86					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42901011	42901011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42901011G>A	ENST00000372565.3	-	6	1032	c.763C>T	c.(763-765)Ctc>Ttc	p.L255F	ZMYND12_ENST00000475426.1_5'UTR|ZMYND12_ENST00000433602.2_Missense_Mutation_p.L145F	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	255						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCTGTGAGAGGACTTGATAG	0.473000													71	193					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55913032	55913032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55913032C>T	ENST00000373965.2	-	15	2027	c.1633G>A	c.(1633-1635)Gaa>Aaa	p.E545K	PCDH15_ENST00000395445.1_Missense_Mutation_p.E545K|PCDH15_ENST00000409834.1_Missense_Mutation_p.E149K|PCDH15_ENST00000437009.1_Missense_Mutation_p.E538K|PCDH15_ENST00000361849.3_Missense_Mutation_p.E538K|PCDH15_ENST00000373957.3_Missense_Mutation_p.E516K|PCDH15_ENST00000395433.1_Missense_Mutation_p.E516K|PCDH15_ENST00000395432.2_Missense_Mutation_p.E501K|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395446.1_Missense_Mutation_p.E538K|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373955.1_Missense_Mutation_p.E538K|PCDH15_ENST00000414778.1_Missense_Mutation_p.E543K|PCDH15_ENST00000395430.1_Missense_Mutation_p.E538K|PCDH15_ENST00000320301.6_Missense_Mutation_p.E538K|PCDH15_ENST00000395438.1_Missense_Mutation_p.E538K	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	538	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.E543K(2)|p.E538K(2)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTGACCCTTCGTCTGCGTCG	0.458000										HNSCC(58;0.16)			12	144					0	0	1	0	0
ANKZF1	55139	broad.mit.edu	37	2	220097337	220097337	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220097337C>T	ENST00000323348.5	+	5	664	c.490C>T	c.(490-492)Cga>Tga	p.R164*	ANKZF1_ENST00000409849.1_5'UTR|ANKZF1_ENST00000410034.3_Nonsense_Mutation_p.R164*	NM_018089.2	NP_060559.2	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing 1	164						intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	23		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTACCCTCATCGAGTTCTTTT	0.537000													35	90					0	0	1	0	0
MORN1	79906	broad.mit.edu	37	1	2288981	2288981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2288981G>A	ENST00000378531.3	-	10	1099	c.926C>T	c.(925-927)cCc>cTc	p.P309L	MORN1_ENST00000606372.1_5'UTR|MORN1_ENST00000378529.3_Missense_Mutation_p.P309L	NM_024848.1	NP_079124.1	Q5T089	MORN1_HUMAN	MORN repeat containing 1	309										breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(1)|ovary(2)	9	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		GGCAGCTCTGGGCCCCGGCAC	0.657000													37	101					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73069424	73069424	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73069424G>A	ENST00000429829.1	-	0	3164					NR_001564.2																						GCTCTCAATTGACATTCCCTA	0.393000													17	13					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427318	135427318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135427318C>T	ENST00000394143.1	+	6	1744	c.1453C>T	c.(1453-1455)Cct>Tct	p.P485S	GPR112_ENST00000370652.1_Missense_Mutation_p.P485S|GPR112_ENST00000394141.1_Missense_Mutation_p.P280S|GPR112_ENST00000412101.1_Missense_Mutation_p.P280S|GPR112_ENST00000287534.4_Missense_Mutation_p.P422S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	485					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TTCTGTATTTCCTAGAAACCA	0.448000													28	40					0	0	1	0	0
MTMR12	54545	broad.mit.edu	37	5	32239246	32239246	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:32239246G>A	ENST00000382142.3	-	13	1375	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	MTMR12_ENST00000280285.5_Missense_Mutation_p.S402F|MTMR12_ENST00000264934.5_Missense_Mutation_p.S402F	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	402	Myotubularin phosphatase.					cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CACCAGAGAGGAAATGAGACA	0.502000													14	52					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154687474	154687474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154687474C>T	ENST00000271915.3	-	6	2022	c.1707G>A	c.(1705-1707)aaG>aaA	p.K569K	KCNN3_ENST00000358505.2_Silent_p.K256K|KCNN3_ENST00000361147.4_Silent_p.K264K	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	574	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			CTGCAGCATTCTTGATCTAAG	0.393000													29	99					0	0	1	0	0
PER1	5187	broad.mit.edu	37	17	8049772	8049772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8049772G>A	ENST00000317276.4	-	16	2193	c.1956C>T	c.(1954-1956)gcC>gcT	p.A652A	PER1_ENST00000581082.1_Silent_p.A632A|PER1_ENST00000578089.1_5'UTR|PER1_ENST00000354903.5_Silent_p.A636A	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	652	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						AGGAGGAGGAGGCACATTTAC	0.592000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					21	43					0	0	1	0	0
PAPD4	167153	broad.mit.edu	37	5	78915544	78915544	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:78915544C>T	ENST00000453514.1	+	2	766	c.73C>T	c.(73-75)Ctg>Ttg	p.L25L	PAPD4_ENST00000428308.2_Silent_p.L25L|PAPD4_ENST00000504233.1_Silent_p.L25L|PAPD4_ENST00000423041.2_Silent_p.L25L|PAPD4_ENST00000296783.3_Silent_p.L25L	NM_001114394.1	NP_001107866.1	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	25					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			biliary_tract(1)|breast(2)|endometrium(4)|kidney(3)|large_intestine(9)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		CTTCTTTACCCTGTCACCTAC	0.408000													27	79					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62398281	62398281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62398281G>A	ENST00000346178.4	-	12	1259	c.1244C>T	c.(1243-1245)tCc>tTc	p.S415F	GANAB_ENST00000534779.1_Missense_Mutation_p.S301F|GANAB_ENST00000356638.3_Missense_Mutation_p.S393F|GANAB_ENST00000540933.1_Missense_Mutation_p.S296F	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	393					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GTAGCCGAGGGAGAAGAGTGG	0.582000													7	21					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237405806	237405806	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:237405806G>A	ENST00000409907.3	-	2	610	c.336_splice	c.e2+1	p.P112_splice	IQCA1_ENST00000309507.5_Splice_Site_p.P108_splice|IQCA1_ENST00000431676.2_Splice_Site_p.P112_splice			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	112							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						GAGTGCTTACGGGGGCCAGCT	0.448000													10	7					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132061443	132061443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:132061443C>T	ENST00000336375.5	+	6	693	c.603C>T	c.(601-603)gaC>gaT	p.D201D	ACPP_ENST00000475741.1_Silent_p.D168D|ACPP_ENST00000351273.7_Silent_p.D201D	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	201						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						ATGGCCAGGACCTTTTTGGAA	0.353000													16	112					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31712336	31712336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:31712336C>T	ENST00000396556.2	-	9	1988	c.1866G>A	c.(1864-1866)gcG>gcA	p.A622A	OSBPL10_ENST00000438237.2_Silent_p.A558A	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	622					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		ATATCACTGTCGCTGAGTACC	0.547000													44	98					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55973911	55973911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55973911C>T	ENST00000263923.4	-	10	1700	c.1405G>A	c.(1405-1407)Gag>Aag	p.E469K		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	469	Ig-like C2-type 5.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACCTGGGCTCGTTGGCGCAC	0.512000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			27	66					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420389	55420389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55420389G>A	ENST00000242994.3	+	2	544	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	56	Asp/Glu-rich (acidic).				amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						CAGTATTgaggaagaagaaga	0.478000													17	44					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71510219	71510219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71510219G>A	ENST00000396073.3	+	9	3357	c.3076G>A	c.(3076-3078)Gaa>Aaa	p.E1026K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	1026					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel	p.E1026Q(1)		haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			TACACCTGATGAAGGCTCCAA	0.433000													20	93					0	0	1	0	0
HOOK1	51361	broad.mit.edu	37	1	60328519	60328519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60328519G>A	ENST00000371208.3	+	16	1853	c.1596G>A	c.(1594-1596)caG>caA	p.Q532Q	HOOK1_ENST00000395561.2_Silent_p.Q490Q|HOOK1_ENST00000465876.1_3'UTR	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1	532	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					AATCTTTACAGGAACAAGGTT	0.368000													21	94					0	0	1	0	0
OR1Q1	158131	broad.mit.edu	37	9	125377471	125377471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125377471C>T	ENST00000297913.2	+	1	524	c.455C>T	c.(454-456)tCc>tTc	p.S152F	RP11-64P14.7_ENST00000431442.1_RNA	NM_012364.1	NP_036496.1	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q, member 1	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	17						CATGCTCTCTCCCACCTTCAT	0.488000													35	96					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30670603	30670603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30670603G>A	ENST00000376406.3	-	13	6564	c.5917C>T	c.(5917-5919)Cct>Tct	p.P1973S	MDC1_ENST00000376405.2_Missense_Mutation_p.P1709S	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1973	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TCTTGCTCAGGGTCGGTCACC	0.547000								Other conserved DNA damage response genes					39	123					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15383628	15383628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15383628G>A	ENST00000263377.2	-	2	504	c.283C>T	c.(283-285)Cct>Tct	p.P95S	BRD4_ENST00000360016.5_Missense_Mutation_p.P95S|BRD4_ENST00000371835.4_Missense_Mutation_p.P95S	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	95	Bromo 1.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			CTACTCACAGGGAGGTTCAGC	0.592000			T	C15orf55	lethal midline carcinoma of young people								6	24					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166847761	166847761	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166847761C>T	ENST00000423058.2	-	26	6041	c.6024G>A	c.(6022-6024)ggG>ggA	p.G2008G	SCN1A_ENST00000409050.1_Silent_p.G1980G|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Silent_p.G1997G|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Silent_p.G2008G	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	2008						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	tcatttatttCCCTTTGGCTT	0.393000													12	19					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165861	151165861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:151165861G>A	ENST00000282466.3	-	4	1907	c.1908C>T	c.(1906-1908)acC>acT	p.T636T		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	636	Ig-like C2-type 2.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTCTTTCGGGGTGACCTGTA	0.418000													31	95					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155295167	155295167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:155295167C>T	ENST00000392825.3	+	12	2026	c.1459C>T	c.(1459-1461)Ctc>Ttc	p.L487F	AC009227.2_ENST00000434635.1_RNA|GALNT13_ENST00000409237.1_Missense_Mutation_p.L487F|GALNT13_ENST00000487047.1_3'UTR	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	487	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						TGTTTCTAGACTCAATGGACC	0.318000													35	90					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434304	72434304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:72434304C>T	ENST00000373517.3	-	1	380	c.25G>A	c.(25-27)Gag>Aag	p.E9K	NAP1L2_ENST00000536638.1_Intron	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	9					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TCTGACAGCTCCTTGCGGTTC	0.547000													25	32					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59962333	59962333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59962333G>A	ENST00000444766.3	-	16	2117	c.2042C>T	c.(2041-2043)tCt>tTt	p.S681F	INTS2_ENST00000251334.6_Missense_Mutation_p.S673F	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	681					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						CATTAAAGAAGAAGAATATGA	0.353000													7	18					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095062	69095062	+	Missense_Mutation	SNP	G	G	A	rs150665678		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69095062G>A	ENST00000332644.5	-	8	1020	c.859C>T	c.(859-861)Cgt>Tgt	p.R287C		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	287	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						CAAATCTTACGAATGTACTCT	0.358000													31	84					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57537224	57537224	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57537224C>T	ENST00000371236.2	-	6	792	c.529G>A	c.(529-531)Gat>Aat	p.D177N	DAB1_ENST00000420954.2_Missense_Mutation_p.D177N|DAB1_ENST00000439789.2_Intron|DAB1_ENST00000371234.4_Missense_Mutation_p.D177N|DAB1_ENST00000371231.1_Missense_Mutation_p.D177N|DAB1_ENST00000414851.2_Missense_Mutation_p.D177N|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371230.1_Missense_Mutation_p.D177N			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	177	PID.				cell differentiation|nervous system development			p.D177Y(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CACTGCTTATCCTTTTGTGCC	0.393000													27	61					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4513602	4513602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4513602C>T	ENST00000301286.3	-	3	327	c.328G>A	c.(328-330)Ggc>Agc	p.G110S		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	110	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						GTGTCCAGGCCTCCCTGGACC	0.657000													5	11					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92191472	92191472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92191472G>A	ENST00000256343.3	-	3	276	c.120C>T	c.(118-120)ttC>ttT	p.F40F		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	40					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TCTCTTGAGGGAACCCTTTGT	0.313000													14	34					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71892314	71892314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71892314G>A	ENST00000258104.3	+	46	5357	c.5080G>A	c.(5080-5082)Gac>Aac	p.D1694N	DYSF_ENST00000410041.1_Missense_Mutation_p.D1712N|DYSF_ENST00000429174.2_Missense_Mutation_p.D1715N|DYSF_ENST00000409744.1_Missense_Mutation_p.D1702N|DYSF_ENST00000410020.3_Missense_Mutation_p.D1733N|DYSF_ENST00000394120.2_Missense_Mutation_p.D1695N|DYSF_ENST00000409366.1_Missense_Mutation_p.D1716N|DYSF_ENST00000409582.3_Missense_Mutation_p.D1732N|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000413539.2_Missense_Mutation_p.D1725N|DYSF_ENST00000409651.1_Missense_Mutation_p.D1726N|DYSF_ENST00000409762.1_Missense_Mutation_p.D1711N	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1694						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CCAGTGGCGGGACCAGCTCCG	0.562000													67	115					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17794534	17794534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:17794534G>A	ENST00000378814.5	-	25	3167	c.3168C>T	c.(3166-3168)atC>atT	p.I1056I	KIF13A_ENST00000378843.2_Silent_p.I1056I|KIF13A_ENST00000259711.6_Silent_p.I1056I|KIF13A_ENST00000378826.2_Silent_p.I1056I|KIF13A_ENST00000378816.5_Silent_p.I1056I	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1056					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTACACAGCCGATGGATACTG	0.468000													38	92					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96777479	96777479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96777479G>A	ENST00000359933.4	-	28	5029	c.4136C>T	c.(4135-4137)cCt>cTt	p.P1379L	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1379										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AAAGGCTCCAGGCTTCATATC	0.448000													38	121					0	0	1	0	0
APLP2	334	broad.mit.edu	37	11	130011906	130011906	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:130011906C>T	ENST00000263574.5	+	17	2199	c.2127C>T	c.(2125-2127)atC>atT	p.I709I	APLP2_ENST00000345598.5_Silent_p.I468I|APLP2_ENST00000539648.1_Silent_p.I497I|APLP2_ENST00000338167.5_Silent_p.I697I|APLP2_ENST00000543137.1_Silent_p.I604I|APLP2_ENST00000278756.7_Silent_p.I707I|APLP2_ENST00000528499.1_Silent_p.I641I	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	709					G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CCACGGTCATCGTCATCAGCC	0.602000													13	23					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235949554	235949554	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:235949554C>T	ENST00000409212.1	+	4	648	c.141C>T	c.(139-141)ctC>ctT	p.L47L	SH3BP4_ENST00000392011.2_Silent_p.L47L|SH3BP4_ENST00000344528.4_Silent_p.L47L			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	47					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GTGCCTTGCTCGTAGACAACC	0.542000													41	97					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	156195	156195	+	Missense_Mutation	SNP	G	G	A	rs138938524		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156195G>A	ENST00000283426.6	+	8	1200	c.1150G>A	c.(1150-1152)Gag>Aag	p.E384K		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	384					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.E384K(2)|p.E384*(1)		endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GGAAGTCGCCGAGTTAATTGA	0.582000													13	75					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39325115	39325115	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39325115C>T	ENST00000287152.7	-	19	2212	c.2118G>A	c.(2116-2118)acG>acA	p.T706T	KIF6_ENST00000394362.1_Silent_p.T157T|KIF6_ENST00000541946.1_Silent_p.T157T|KIF6_ENST00000373216.3_Silent_p.T706T|KIF6_ENST00000373213.4_Silent_p.T545T|KIF6_ENST00000373215.3_Silent_p.T689T|KIF6_ENST00000538893.1_Silent_p.T650T|KIF6_ENST00000229913.5_Silent_p.T157T	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	706					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GAAATGGCTTCGTGTGATCGA	0.458000													38	91					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6964814	6964814	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6964814G>A	ENST00000278319.5	+	6	1242	c.654G>A	c.(652-654)ttG>ttA	p.L218L	ZNF215_ENST00000529903.1_Silent_p.L218L|ZNF215_ENST00000527171.1_3'UTR|ZNF215_ENST00000414517.2_Silent_p.L218L	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	218	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		GCCTTAAGTTGGAGAGTAAGA	0.343000													54	120					0	0	1	0	0
SIRPB2	284759	broad.mit.edu	37	20	1456817	1456817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1456817C>T	ENST00000359801.3	-	5	1060	c.1024G>A	c.(1024-1026)Gag>Aag	p.E342K	SIRPB2_ENST00000444444.1_Missense_Mutation_p.E244K	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	342						integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						ACCCCTCACTCTTGACCCTTG	0.612000													30	94					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531707	50531707	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50531707C>T	ENST00000374144.3	+	3	1405	c.1117C>T	c.(1117-1119)Caa>Taa	p.Q373*	C10orf71_ENST00000323868.4_Nonsense_Mutation_p.Q373*			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	373										endometrium(1)	1						ACCTGATTCTCAAGAGAAGCC	0.512000													16	69					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17603053	17603053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17603053C>T	ENST00000375460.3	+	12	1387	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	449					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGCGGGACTTCCTCCATGCCC	0.552000													20	80					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95604162	95604162	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95604162G>A	ENST00000343958.4	-	2	1121	c.898C>T	c.(898-900)Ccc>Tcc	p.P300S	FGD6_ENST00000546711.1_Missense_Mutation_p.P300S|FGD6_ENST00000549499.1_Missense_Mutation_p.P300S	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	300					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						ATTTCTAAGGGACCAAGGTCT	0.403000													42	108					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12969363	12969363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12969363G>A	ENST00000251472.4	+	12	1215	c.1176G>A	c.(1174-1176)cgG>cgA	p.R392R	MAST1_ENST00000591495.1_Silent_p.R388R	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	392	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						ACCTGGTGCGGCACCGCGACA	0.657000													21	57					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120801536	120801536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:120801536G>A	ENST00000369144.3	-	19	3623	c.3496C>T	c.(3496-3498)Cct>Tct	p.P1166S	EIF3A_ENST00000541549.1_Missense_Mutation_p.P1132S|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1166	25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].|Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CAAGGACCAGGTCTTGAGTCA	0.443000													21	66					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55569295	55569295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:55569295C>T	ENST00000395438.1	-	36	4959	c.4565G>A	c.(4564-4566)aGa>aAa	p.R1522K	PCDH15_ENST00000395445.1_Silent_p.K1505K|PCDH15_ENST00000409834.1_Missense_Mutation_p.R1133K|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395440.1_Silent_p.K439K|PCDH15_ENST00000395446.1_Silent_p.K701K|PCDH15_ENST00000395442.1_Silent_p.K370K|PCDH15_ENST00000414778.1_Intron	NM_001142770.1	NP_001136242.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTTAATTTTCTTTGGCTCTT	0.403000										HNSCC(58;0.16)			45	231					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17496474	17496474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17496474G>A	ENST00000302539.4	-	2	374	c.249C>T	c.(247-249)ttC>ttT	p.F83F	ABCC8_ENST00000389817.3_Silent_p.F83F	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	83					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACACCAGGACGAAGAGCAGCA	0.547000													19	50					0	0	1	0	0
ACTR1A	10121	broad.mit.edu	37	10	104241922	104241922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104241922G>A	ENST00000369905.4	-	8	824	c.761C>T	c.(760-762)tCc>tTc	p.S254F	ACTR1A_ENST00000545684.1_Missense_Mutation_p.S180F|ACTR1A_ENST00000487599.1_Missense_Mutation_p.S254F|ACTR1A_ENST00000470322.1_5'UTR|ACTR1A_ENST00000446605.2_Missense_Mutation_p.S207F	NM_005736.3	NP_005727.1	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	254					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	13		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CCGGAATCGGGAAGGACCAAT	0.582000													35	114					0	0	1	0	0
C10orf128	170371	broad.mit.edu	37	10	50396355	50396355	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50396355C>T	ENST00000374148.1	-	1	81	c.27G>A	c.(25-27)agG>agA	p.R9R	C10orf128_ENST00000374151.3_Silent_p.R9R|C10orf128_ENST00000470884.1_5'UTR|C10orf128_ENST00000374153.2_Silent_p.R9R|C10orf128_ENST00000474718.1_Silent_p.R9R			Q5T292	CJ128_HUMAN	chromosome 10 open reading frame 128	9						integral to membrane				breast(1)|large_intestine(1)|lung(1)	3						GGAAGAGGATCCTCAGCATGC	0.647000													26	84					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286549	152286549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152286549C>T	ENST00000368799.1	-	3	848	c.813G>A	c.(811-813)gtG>gtA	p.V271V	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	271	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGACCTGTTCACTTGAGATG	0.438000									Ichthyosis				27	309					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36050801	36050801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36050801G>A	ENST00000262623.3	-	7	990	c.962C>T	c.(961-963)gCc>gTc	p.A321V		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	321					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AATGCACATGGCCACAATAAA	0.547000													31	58					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72842210	72842210	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72842210C>T	ENST00000293190.5	-	11	2491	c.2345G>A	c.(2344-2346)gGg>gAg	p.G782E	GRIN2C_ENST00000347612.4_Missense_Mutation_p.G782E	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	782					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CCCACCGTCCCCCAGGAACTG	0.612000													34	104					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31590878	31590878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31590878C>T	ENST00000379416.3	-	20	2194	c.2146G>A	c.(2146-2148)Gag>Aag	p.E716K		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	716					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity	p.E716*(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TCCCCTTTCTCGATCTTCAGC	0.468000													109	71					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31920407	31920407	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31920407C>T	ENST00000396184.3	-	4	399	c.195G>A	c.(193-195)ttG>ttA	p.L65L	PDE1C_ENST00000396191.1_Silent_p.L65L|PDE1C_ENST00000321453.7_Silent_p.L65L|PDE1C_ENST00000396193.1_Silent_p.L125L|PDE1C_ENST00000396182.2_Silent_p.L65L	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	65					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CTGCATATTCCAAATTCTTCT	0.308000													51	114					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156877930	156877930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156877930G>A	ENST00000338302.3	+	10	1138	c.913G>A	c.(913-915)Gag>Aag	p.E305K	PEAR1_ENST00000292357.7_Missense_Mutation_p.E305K			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	305						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTGCCGGGAGGAGTGCCCGGT	0.711000													4	14					0	0	1	0	0
SPSB1	80176	broad.mit.edu	37	1	9416153	9416153	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9416153A>G	ENST00000328089.6	+	2	544	c.203A>G	c.(202-204)aAg>aGg	p.K68R	SPSB1_ENST00000377399.2_Missense_Mutation_p.K68R|SPSB1_ENST00000357898.3_Missense_Mutation_p.K68R	NM_025106.3	NP_079382.2	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box containing 1	68	B30.2/SPRY.				intracellular signal transduction	cytoplasm				breast(1)|endometrium(3)|kidney(2)|lung(5)|prostate(2)	13	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		GTCTTTGTGAAGGAGGACGAC	0.577000													51	165					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54805618	54805618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:54805618C>T	ENST00000306858.7	+	5	1965	c.1849C>T	c.(1849-1851)Cct>Tct	p.P617S		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	617										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					CTTGCAGGTTCCTGAAAACCA	0.413000													20	69					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92848455	92848455	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92848455C>T	ENST00000394468.2	-	2	466	c.389G>A	c.(388-390)gGa>gAa	p.G130E	HEPACAM2_ENST00000341723.4_Missense_Mutation_p.G118E|HEPACAM2_ENST00000453812.2_Missense_Mutation_p.G153E|HEPACAM2_ENST00000440868.1_Missense_Mutation_p.G118E	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	130						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						AGATAGAGTTCCATTTCCCTG	0.483000													17	50					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35804209	35804209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35804209G>A	ENST00000392213.3	+	11	1892	c.1733G>A	c.(1732-1734)gGa>gAa	p.G578E	MAG_ENST00000361922.4_3'UTR|MAG_ENST00000537831.2_Missense_Mutation_p.G553E	NM_002361.3	NP_002352.1	P20916	MAG_HUMAN	myelin associated glycoprotein	578					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			AGGCGCCTGGGATCTGAGAGG	0.622000													16	89					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31774775	31774775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:31774775C>T	ENST00000396556.2	-	6	1191	c.1069G>A	c.(1069-1071)Gaa>Aaa	p.E357K	OSBPL10_ENST00000438237.2_Missense_Mutation_p.E293K|OSBPL10_ENST00000467647.1_5'UTR	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	357					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		GAGGTTTGTTCGTCTTCAGCA	0.453000													26	118					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53908220	53908220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:53908220C>T	ENST00000396328.1	-	15	2422	c.2183G>A	c.(2182-2184)aGa>aAa	p.R728K	WDR72_ENST00000360509.5_Missense_Mutation_p.R728K|WDR72_ENST00000559418.1_Missense_Mutation_p.R738K|WDR72_ENST00000557913.1_Missense_Mutation_p.R725K	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	728										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTTACTTTTTCTCAGTGTCAG	0.468000													26	80					0	0	1	0	0
FGD4	121512	broad.mit.edu	37	12	32760940	32760940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32760940C>T	ENST00000427716.2	+	8	1467	c.1043C>T	c.(1042-1044)cCt>cTt	p.P348L	FGD4_ENST00000534526.2_Missense_Mutation_p.P485L|FGD4_ENST00000266482.3_Missense_Mutation_p.P100L|FGD4_ENST00000546442.1_Missense_Mutation_p.P255L|FGD4_ENST00000525053.1_Missense_Mutation_p.P460L|FGD4_ENST00000531134.1_Missense_Mutation_p.P433L|FGD4_ENST00000381025.3_Missense_Mutation_p.P100L	NM_139241.2	NP_640334.2	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	348	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	27	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					ATGCTAGAACCTGTTCAGCGG	0.393000													61	131					0	0	1	0	0
DBX1	120237	broad.mit.edu	37	11	20181577	20181577	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20181577G>A	ENST00000524983.2	-	1	582	c.294C>T	c.(292-294)gcC>gcT	p.A98A	DBX1_ENST00000227256.3_Silent_p.A98A			A6NMT0	DBX1_HUMAN	developing brain homeobox 1	98					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)	21						CAGGGGAGAAGGCAGTCGGCG	0.706000													5	8					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690158	33690158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:33690158G>A	ENST00000394566.1	-	4	941	c.669C>T	c.(667-669)ttC>ttT	p.F223F	SLFN11_ENST00000308377.4_Silent_p.F223F	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	223						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CATATTCTTGGAAGTGTTTTG	0.378000													24	128					0	0	1	0	0
MICU3	286097	broad.mit.edu	37	8	16961987	16961987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:16961987G>A	ENST00000318063.5	+	10	1114	c.1072G>A	c.(1072-1074)Gaa>Aaa	p.E358K	MICU3_ENST00000519866.1_3'UTR	NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		GCTCAACTTTGAAGATTTTTA	0.294000													33	68					0	0	1	0	0
DYNAP	284254	broad.mit.edu	37	18	52262300	52262300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52262300C>T	ENST00000321600.1	+	2	312	c.266C>T	c.(265-267)tCa>tTa	p.S89L	DYNAP_ENST00000585973.1_Intron	NM_173629.1	NP_775900.1			dynactin associated protein																		CTTGCACATTCAAGATGTCTA	0.448000													55	69					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282402	152282402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152282402C>T	ENST00000368799.1	-	3	4995	c.4960G>A	c.(4960-4962)Ggc>Agc	p.G1654S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1654	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACGAGTGCCTGATTGTCTG	0.562000									Ichthyosis				145	398					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299276	58299276	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58299276G>A	ENST00000377918.3	+	4	3354	c.3328G>A	c.(3328-3330)Gat>Aat	p.D1110N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1110					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGCCAGCCGGGATTCCAGTGA	0.517000													53	168					0	0	1	0	0
TATDN2	9797	broad.mit.edu	37	3	10290984	10290984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10290984C>T	ENST00000287652.4	+	2	1151	c.100C>T	c.(100-102)Ccc>Tcc	p.P34S	TATDN2_ENST00000448281.2_Missense_Mutation_p.P34S	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	34						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						TGATGTGGCCCCCTCCAGCCG	0.682000													36	69					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327597	85327597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:85327597C>T	ENST00000299927.3	+	1	1713	c.1691C>T	c.(1690-1692)cCc>cTc	p.P564L	ZNF592_ENST00000560079.2_Missense_Mutation_p.P564L			Q92610	ZN592_HUMAN	zinc finger protein 592	564					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCTCCAACCCCGTGCCCCTC	0.597000													52	186					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126715450	126715450	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:126715450G>A	ENST00000309035.6	-	1	1009	c.879C>T	c.(877-879)ttC>ttT	p.F293F	CTBP2_ENST00000494626.2_Intron|CTBP2_ENST00000411419.2_Intron|CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000337195.5_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GAAAGGCCAGGAACTCAGGGA	0.647000													5	53					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31710235	31710235	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:31710235G>A	ENST00000396556.2	-	10	2117	c.1995C>T	c.(1993-1995)ttC>ttT	p.F665F	OSBPL10_ENST00000438237.2_Silent_p.F601F	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	665					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		TGTTGTAGGTGAACTCTAAAG	0.458000													50	101					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6468113	6468113	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6468113C>T	ENST00000381480.2	-	23	1920	c.1808G>A	c.(1807-1809)tGg>tAg	p.W603*	DENND1C_ENST00000543576.1_Nonsense_Mutation_p.W559*	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	603						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GTCTGGTTGCCATCTTGGTAT	0.537000													13	25					0	0	1	0	0
CPVL	54504	broad.mit.edu	37	7	29132281	29132281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:29132281C>T	ENST00000409850.1	-	10	1146	c.500G>A	c.(499-501)gGa>gAa	p.G167E	CPVL_ENST00000265394.5_Missense_Mutation_p.G167E|CPVL_ENST00000396276.3_Missense_Mutation_p.G167E			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	167					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						GACTGCATATCCGTGGGTATC	0.438000													10	55					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120371457	120371457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120371457C>T	ENST00000283871.5	-	5	783	c.324G>A	c.(322-324)aaG>aaA	p.K108K		NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	108					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		AGTCTACTTTCTTCTGAGATG	0.428000													11	46					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940807	113940807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:113940807G>A	ENST00000245796.6	+	2	969	c.774G>A	c.(772-774)gaG>gaA	p.E258E	PSD4_ENST00000441564.2_Silent_p.E258E	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	258					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity	p.E258E(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTTGCTCAGAGAACAGTGCTT	0.607000													28	65					0	0	1	0	0
LTF	4057	broad.mit.edu	37	3	46497370	46497370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46497370G>A	ENST00000231751.4	-	4	710	c.415C>T	c.(415-417)Cgc>Tgc	p.R139C	LTF_ENST00000417439.1_Missense_Mutation_p.R139C|LTF_ENST00000426532.2_Missense_Mutation_p.R95C	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	139	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	GCGGTCCTGCGAAGGCCTGTG	0.562000													13	39					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370636	240370636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240370636G>A	ENST00000319653.9	+	5	2754	c.2524G>A	c.(2524-2526)Gaa>Aaa	p.E842K		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	842	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.E985K(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AACCAGCCACGAACACTCTGT	0.557000													27	90					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70953127	70953127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70953127C>T	ENST00000334414.6	-	18	4754	c.4710G>A	c.(4708-4710)agG>agA	p.R1570R	PTPRB_ENST00000550358.1_Silent_p.R1482R|PTPRB_ENST00000551525.1_Silent_p.R1569R|PTPRB_ENST00000261266.5_Silent_p.R1352R|PTPRB_ENST00000451516.2_Silent_p.R1262R|PTPRB_ENST00000538708.1_Silent_p.R1262R|PTPRB_ENST00000550857.1_Silent_p.R1262R	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1352					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCATACTTGTCCTCACAGATC	0.378000													62	123					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105421084	105421084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105421084C>T	ENST00000333244.5	-	7	823	c.704G>A	c.(703-705)gGa>gAa	p.G235E		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	235						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCCCCATCTCCTTCCAGAGT	0.537000													14	24					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475258	140475258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140475258G>A	ENST00000194155.4	+	1	1032	c.884G>A	c.(883-885)cGa>cAa	p.R295Q		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		295	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAACGTTTCGATTAAGTGCA	0.428000													10	103					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798442	55798442	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55798442C>T	ENST00000313555.1	+	1	548	c.548C>T	c.(547-549)cCt>cTt	p.P183L		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					GATATCCCACCTCTTCTGGCT	0.423000													84	300					0	0	1	0	0
LIN54	132660	broad.mit.edu	37	4	83905984	83905984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:83905984G>A	ENST00000340417.3	-	2	391	c.14C>T	c.(13-15)cCa>cTa	p.P5L	LIN54_ENST00000510557.1_Missense_Mutation_p.P5L|LIN54_ENST00000505397.1_Missense_Mutation_p.P5L|LIN54_ENST00000395283.2_Missense_Mutation_p.P5L|LIN54_ENST00000506560.1_Missense_Mutation_p.P5L|LIN54_ENST00000442461.2_Missense_Mutation_p.P5L|LIN54_ENST00000446851.2_Missense_Mutation_p.P5L|LIN54_ENST00000395282.2_Missense_Mutation_p.P5L	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	5					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				CACCTCAGCTGGCACCACCTC	0.383000													24	126					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159170684	159170684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159170684G>A	ENST00000368125.4	+	9	1326	c.1169G>A	c.(1168-1170)gGg>gAg	p.G390E	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000497636.1_3'UTR|CADM3_ENST00000368124.4_Missense_Mutation_p.G424E	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	390					adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					CAGTCAGGAGGGGACGACAAG	0.612000													17	91					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16411782	16411782	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:16411782C>T	ENST00000334133.4	-	6	1103	c.831G>A	c.(829-831)atG>atA	p.M277I	RFTN1_ENST00000432519.1_Missense_Mutation_p.M241I|RFTN1_ENST00000483671.1_5'UTR	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	277						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						TGAAGATCTCCATTTCTGTTG	0.458000													79	193					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117053514	117053514	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:117053514C>T	ENST00000371876.1	-	3	2808	c.387G>A	c.(385-387)ttG>ttA	p.L129L	KLHL13_ENST00000262820.3_Silent_p.L180L|KLHL13_ENST00000371878.1_Silent_p.L129L|KLHL13_ENST00000371882.1_Silent_p.L129L|KLHL13_ENST00000541812.1_Silent_p.L164L|KLHL13_ENST00000545703.1_Silent_p.L138L|KLHL13_ENST00000469946.1_Silent_p.L129L|KLHL13_ENST00000539496.1_Silent_p.L183L|KLHL13_ENST00000540167.1_Silent_p.L164L			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	180	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						TACAGAAGTCCAAAACTGGCA	0.373000													56	35					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56044681	56044681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:56044681C>T	ENST00000244728.5	-	3	732	c.335G>A	c.(334-336)gGa>gAa	p.G112E	COL21A1_ENST00000535941.1_Missense_Mutation_p.G112E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G112E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	112	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTTTGTGTTTCCTCCTAAGTA	0.468000													17	34					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28725631	28725631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28725631G>A	ENST00000257197.3	-	7	1143	c.882C>T	c.(880-882)ttC>ttT	p.F294F	DSC1_ENST00000257198.5_Silent_p.F294F|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	294	Cadherin 2.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GGTGTATGGAGAAATGCTTTG	0.393000													15	153					0	0	1	0	0
OR7E24	26648	broad.mit.edu	37	19	9362178	9362178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9362178C>T	ENST00000456448.1	+	1	573	c.459C>T	c.(457-459)atC>atT	p.I153I		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						ACCGAATCATCATGAACCCAC	0.443000													18	54					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	98006768	98006768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98006768C>T	ENST00000224337.5	-	2	226	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	BLNK_ENST00000371176.2_Missense_Mutation_p.E29K|BLNK_ENST00000413476.2_Missense_Mutation_p.E29K|BLNK_ENST00000427367.2_Missense_Mutation_p.E29K|BLNK_ENST00000495266.1_Missense_Mutation_p.E29K	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	29					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ATTCCACCTTCATTGTTTTTA	0.259000													25	81					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137658856	137658856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137658856G>A	ENST00000371817.3	+	23	2558	c.2144G>A	c.(2143-2145)gGa>gAa	p.G715E		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	715	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGTCCCCAGGGAGAGCCTGGC	0.647000													5	19					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10742306	10742306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10742306C>T	ENST00000586078.1	+	8	616	c.507C>T	c.(505-507)gcC>gcT	p.A169A	SLC44A2_ENST00000335757.5_Silent_p.A169A|SLC44A2_ENST00000407327.4_Silent_p.A167A	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	169					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	ATGCAGTGGCCCGGAGATGCT	0.607000													12	24					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032393	142032393	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142032393G>A	ENST00000547918.2	+	0	246																											TCCAAGGCAAGGATGCAGCAG	0.532000													8	26					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81134856	81134856	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:81134856G>A	ENST00000525539.1	-	0	7250				PKD1L2_ENST00000533478.1_RNA|PKD1L2_ENST00000534142.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ATTTTCATCAGCAGCAAATCT	0.522000													15	39					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886741	23886741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23886741G>A	ENST00000355349.3	-	31	4486	c.4324C>T	c.(4324-4326)Ctg>Ttg	p.L1442L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1442					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCTTGTCCAGGGCTGCAGCA	0.612000													42	121					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32752500	32752500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32752500C>T	ENST00000380250.3	+	21	3104	c.2608C>T	c.(2608-2610)Ccc>Tcc	p.P870S		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CAAGCACTGCCCCACAGCCCT	0.557000													47	137					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77764371	77764371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:77764371G>A	ENST00000354212.4	-	17	3251	c.2998C>T	c.(2998-3000)Ctt>Ttt	p.L1000F	MAGI2_ENST00000522391.1_Missense_Mutation_p.L1000F|MAGI2_ENST00000419488.1_Missense_Mutation_p.L986F	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1000	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GTGACACTAAGACCTGCATCC	0.537000													24	66					0	0	1	0	0
FBXO38	81545	broad.mit.edu	37	5	147803583	147803583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147803583C>T	ENST00000340253.5	+	13	1809	c.1641C>T	c.(1639-1641)atC>atT	p.I547I	FBXO38_ENST00000394370.3_Silent_p.I547I|FBXO38_ENST00000513826.1_Silent_p.I547I|FBXO38_ENST00000296701.6_Silent_p.I547I			Q6PIJ6	FBX38_HUMAN	F-box protein 38	547						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAAGACATCGTCCAAGAAG	0.433000													18	61					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170244629	170244629	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170244629C>T	ENST00000231706.4	-	2	412	c.97G>A	c.(97-99)Gag>Aag	p.E33K	CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	33						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AGCATGGACTCCACTGGTTTG	0.592000													4	29					0	0	1	0	0
C1orf200	644997	broad.mit.edu	37	1	9714487	9714487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9714487G>A	ENST00000377320.3	-	1	157	c.8C>T	c.(7-9)tCc>tTc	p.S3F	PIK3CD_ENST00000536656.1_Intron|PIK3CD_ENST00000377346.4_Intron					chromosome 1 open reading frame 200											endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)	9	all_lung(157;0.222)	Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.86e-08)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(185;0.000231)|KIRC - Kidney renal clear cell carcinoma(229;0.000879)|BRCA - Breast invasive adenocarcinoma(304;0.00178)|STAD - Stomach adenocarcinoma(132;0.00331)|READ - Rectum adenocarcinoma(331;0.0419)		GGCAGACTGGGAGGGCATCAG	0.577000													23	50					0	0	1	0	0
C4orf33	132321	broad.mit.edu	37	4	130023817	130023817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:130023817C>T	ENST00000281146.4	+	2	773	c.52C>T	c.(52-54)Ccc>Tcc	p.P18S	C4orf33_ENST00000425929.1_Missense_Mutation_p.P18S|C4orf33_ENST00000502887.1_Missense_Mutation_p.P18S	NM_173487.2	NP_775758.2	Q8N1A6	CD033_HUMAN	chromosome 4 open reading frame 33	18										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	10						GAAGCATGAGCCCGTATTTAT	0.398000													20	83					0	0	1	0	0
GPX3	2878	broad.mit.edu	37	5	150407532	150407532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150407532G>A	ENST00000388825.4	+	5	614	c.522G>A	c.(520-522)atG>atA	p.M174I	GPX3_ENST00000517973.1_3'UTR	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	174					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	GGGAACCCATGAAGGTTCACG	0.567000													19	60					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	484775	484775	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:484775C>T	ENST00000264938.3	-	5	801	c.792G>A	c.(790-792)gtG>gtA	p.V264V	SLC9A3_ENST00000514375.1_Silent_p.V264V	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	264						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGACCACCCCCACCAGCGTGC	0.647000													29	66					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182597411	182597411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:182597411C>T	ENST00000323116.5	+	20	2640	c.2380C>T	c.(2380-2382)Cgt>Tgt	p.R794C		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	794					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			ATTATGCTGTCGTATGGCTCC	0.358000													17	104					0	0	1	0	0
ZSCAN23	222696	broad.mit.edu	37	6	28403867	28403867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28403867G>A	ENST00000289788.4	-	2	322	c.177C>T	c.(175-177)tcC>tcT	p.S59S	ZSCAN23_ENST00000486481.1_Intron	NM_001012455.1	NP_001012458.1	Q3MJ62	ZSC23_HUMAN	zinc finger and SCAN domain containing 23	59	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|prostate(1)|stomach(2)	4						GGGGCCCAGGGGACTCCTGAT	0.552000													19	41					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123887120	123887120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123887120C>T	ENST00000320891.4	+	1	839	c.839C>T	c.(838-840)cCc>cTc	p.P280L		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGCTGACGCCCCTTCTCAAC	0.463000													22	89					0	0	1	0	0
NFIA	4774	broad.mit.edu	37	1	61553906	61553906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:61553906G>A	ENST00000403491.3	+	2	597	c.113G>A	c.(112-114)cGa>cAa	p.R38Q	NFIA_ENST00000371184.2_Missense_Mutation_p.R38Q|NFIA_ENST00000407417.3_Missense_Mutation_p.R30Q|NFIA_ENST00000371185.2_Missense_Mutation_p.R38Q|NFIA_ENST00000371189.4_Missense_Mutation_p.R83Q|NFIA_ENST00000371191.1_Missense_Mutation_p.R61Q|NFIA_ENST00000371187.3_Missense_Mutation_p.R38Q|NFIA_ENST00000485903.2_Missense_Mutation_p.R38Q|NFIA_ENST00000479364.1_Intron	NM_001134673.3|NM_005595.4	NP_001128145.1|NP_005586.1	Q12857	NFIA_HUMAN	nuclear factor I/A	38					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding		NFIA/EHF(2)	endometrium(1)|kidney(2)|large_intestine(8)|lung(20)|pancreas(1)|prostate(1)|skin(1)	34						GCCCGAAAACGAAAATACTTC	0.438000													33	172					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38949934	38949934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38949934G>A	ENST00000355481.4	+	19	2447	c.2316G>A	c.(2314-2316)ctG>ctA	p.L772L	RYR1_ENST00000359596.3_Silent_p.L772L|RYR1_ENST00000360985.3_Silent_p.L772L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	772	B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCTTCAACCTGGACGGGCTCT	0.602000													14	46					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29044306	29044306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29044306C>T	ENST00000257189.4	+	9	1315	c.1232C>T	c.(1231-1233)gCc>gTc	p.A411V		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	411	Cadherin 4.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACATATCAAGCCATCGATGAG	0.358000													20	70					0	0	1	0	0
C1orf141	400757	broad.mit.edu	37	1	67560983	67560983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:67560983C>T	ENST00000371007.2	-	7	647	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K	C1orf141_ENST00000371006.1_Missense_Mutation_p.E180K|C1orf141_ENST00000544837.1_Missense_Mutation_p.E180K	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	180										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						TTTTTCAATTCATCCTCAAAG	0.323000													15	38					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32689700	32689700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:32689700C>T	ENST00000421745.2	+	25	5199	c.5065C>T	c.(5065-5067)Cat>Tat	p.H1689Y		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1689					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					ATTCTTCATTCATCCATCTGA	0.488000													12	35					0	0	1	0	0
MAPK6	5597	broad.mit.edu	37	15	52356461	52356461	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52356461C>T	ENST00000261845.5	+	6	2237	c.1430C>T	c.(1429-1431)tCc>tTc	p.S477F	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	477					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		ATAGATCTTTCCAATTGGAAA	0.348000													9	35					0	0	1	0	0
ALDOB	229	broad.mit.edu	37	9	104184165	104184165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104184165C>T	ENST00000374855.4	-	9	1145	c.1021G>A	c.(1021-1023)Gga>Aga	p.G341R		NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	341					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				ACATACTGTCCTTTGGCCGCC	0.542000													8	52					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891226	18891226	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18891226G>A	ENST00000317658.3	+	1	182	c.24G>A	c.(22-24)agG>agA	p.R8R		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	8					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				TGCTGAGCAGGAAGGACAAGG	0.433000													25	75					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160708785	160708785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160708785G>A	ENST00000263636.4	-	21	2837	c.2810C>T	c.(2809-2811)tCg>tTg	p.S937L	LY75-CD302_ENST00000504764.1_Missense_Mutation_p.S937L|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.S937L|LY75_ENST00000553424.1_Missense_Mutation_p.S937L|LY75_ENST00000554112.1_Missense_Mutation_p.S937L	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TTTCTCTAACGAAGAAACATT	0.373000													23	84					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177247706	177247706	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177247706C>T	ENST00000361539.4	+	7	1332	c.1020C>T	c.(1018-1020)ttC>ttT	p.F340F	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		340						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CAGAAGAGTTCCAGGCCCTGC	0.587000													37	275					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3614464	3614464	+	RNA	SNP	G	G	A	rs150523532	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3614464G>A	ENST00000301749.7	-	0	879				NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000359128.5_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGAGGCGGACGAAGTGCCTCA	0.657000													10	32					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65253698	65253698	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65253698C>T	ENST00000389722.3	-	15	3038	c.2985G>A	c.(2983-2985)agG>agA	p.R995R	SPTB_ENST00000556626.1_Silent_p.R995R|SPTB_ENST00000542895.1_Silent_p.R995R|SPTB_ENST00000389721.5_Silent_p.R995R|SPTB_ENST00000389720.3_Silent_p.R995R	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	995					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton	p.R995R(1)		breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTGACAACTTCCTCTGGATGG	0.607000													20	39					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56087734	56087734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56087734C>T	ENST00000429804.2	-	7	1815	c.1255G>A	c.(1255-1257)Gaa>Aaa	p.E419K	CTCFL_ENST00000422869.2_Missense_Mutation_p.E469K|CTCFL_ENST00000422109.2_Intron|CTCFL_ENST00000433949.2_Missense_Mutation_p.E469K|CTCFL_ENST00000502686.2_Missense_Mutation_p.E207K|CTCFL_ENST00000371196.2_Missense_Mutation_p.E469K|CTCFL_ENST00000423479.2_Missense_Mutation_p.E469K|CTCFL_ENST00000539382.1_Missense_Mutation_p.E264K|CTCFL_ENST00000426658.2_3'UTR|CTCFL_ENST00000243914.3_Missense_Mutation_p.E469K|CTCFL_ENST00000432255.2_Intron	NM_001269046.1	NP_001255975.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	469					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GCATAGCGTTCATGGAAGACA	0.443000													22	48					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45472270	45472270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45472270C>T	ENST00000291574.4	+	4	570	c.395C>T	c.(394-396)gCc>gTc	p.A132V	TRAPPC10_ENST00000380221.3_Missense_Mutation_p.A132V	NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	132					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						GAAAATGATGCCAAGAAAAAA	0.368000													29	119					0	0	1	0	0
MXRA8	54587	broad.mit.edu	37	1	1290374	1290374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1290374C>T	ENST00000309212.6	-	5	667	c.637G>A	c.(637-639)Ggg>Agg	p.G213R	MXRA8_ENST00000342753.4_Missense_Mutation_p.G112R|MXRA8_ENST00000445648.2_Missense_Mutation_p.G213R	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	213	Ig-like V-type 2.					integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGCGGGACCCCGGGCGGCTGC	0.741000													5	7					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179736188	179736188	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179736188C>T	ENST00000420890.2	-	14	2288	c.2171G>A	c.(2170-2172)cGa>cAa	p.R724Q	CCDC141_ENST00000295723.5_Missense_Mutation_p.R149Q	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	149							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCATTTTTGTCGTAGATCTAA	0.393000													74	157					0	0	1	0	0
GHRHR	2692	broad.mit.edu	37	7	31013635	31013635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31013635C>T	ENST00000409904.3	+	4	699	c.441C>T	c.(439-441)ttC>ttT	p.F147F	GHRHR_ENST00000461424.1_3'UTR|GHRHR_ENST00000326139.2_Silent_p.F211F|GHRHR_ENST00000409316.1_Intron			Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	211					activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			biliary_tract(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35					Sermorelin(DB00010)	CCTCCCATTTCGCCACCATGA	0.627000													19	78					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186541233	186541233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186541233C>T	ENST00000431808.1	-	15	3139	c.2576G>A	c.(2575-2577)gGa>gAa	p.G859E	SORBS2_ENST00000449407.2_Missense_Mutation_p.G403E|SORBS2_ENST00000437304.2_Missense_Mutation_p.G583E|SORBS2_ENST00000448662.2_Missense_Mutation_p.G420E|SORBS2_ENST00000355634.5_Missense_Mutation_p.G959E|SORBS2_ENST00000319471.9_Missense_Mutation_p.G490E|SORBS2_ENST00000498125.1_5'UTR|SORBS2_ENST00000393528.3_Missense_Mutation_p.G425E|SORBS2_ENST00000418609.1_Missense_Mutation_p.G763E|SORBS2_ENST00000284776.7_Missense_Mutation_p.G859E			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	859						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TTCTGGAGTTCCTCTTCTTTC	0.438000													94	232					0	0	1	0	0
OR6B2	389090	broad.mit.edu	37	2	240969788	240969788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:240969788G>A	ENST00000402971.2	-	1	118	c.59C>T	c.(58-60)gCc>gTc	p.A20V		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		CAGCCCTGGGGCCGTGGGGAG	0.582000													6	58					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74540379	74540379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:74540379C>T	ENST00000354431.4	-	6	1154	c.963G>A	c.(961-963)atG>atA	p.M321I	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.M321I	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	321										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTTTTGATTTCATGCCTAGAT	0.224000													8	13					0	0	1	0	0
PARP3	10039	broad.mit.edu	37	3	51979178	51979178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51979178C>T	ENST00000417220.2	+	7	1287	c.799C>T	c.(799-801)Cac>Tac	p.H267Y	PARP3_ENST00000431474.1_Missense_Mutation_p.H267Y|PARP3_ENST00000398755.3_Missense_Mutation_p.H274Y			Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	267	PARP alpha-helical.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CAACTTCGGCCACAGCCAGCC	0.652000													44	114					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350329	100350329	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100350329C>T	ENST00000542585.1	+	0	2749				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCACCATCTCCCCAGAAAAAC	0.483000													42	116					0	0	1	0	0
PNPT1	87178	broad.mit.edu	37	2	55894164	55894164	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:55894164G>C	ENST00000447944.2	-	13	1224	c.1138C>G	c.(1138-1140)Ctt>Gtt	p.L380V		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	380					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GATCCATGAAGGGTTTTAAAC	0.308000													16	39					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94668201	94668201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94668201G>A	ENST00000260526.6	-	11	1224	c.1042C>T	c.(1042-1044)Cgt>Tgt	p.R348C	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.R348C	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	348					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TCTTCTGCACGAAACATGGAA	0.408000													54	141					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70500887	70500887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:70500887C>T	ENST00000428974.2	+	5	521	c.463C>T	c.(463-465)Cct>Tct	p.P155S	FUK_ENST00000571514.1_Intron|FUK_ENST00000288078.6_Intron|FUK_ENST00000378912.2_Intron			Q8N0W3	FUK_HUMAN	fucokinase	611						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				GGACTGCCTTCCTTCGTCACA	0.647000													11	30					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89924433	89924433	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89924433G>A	ENST00000405460.2	+	8	1389	c.1293G>A	c.(1291-1293)gcG>gcA	p.A431A		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	431					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGTCTCTGCGAATTGGGTGT	0.418000													20	69					0	0	1	0	0
ATP6V0E2	155066	broad.mit.edu	37	7	149576474	149576474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149576474C>T	ENST00000421974.2	+	3	1301	c.350C>T	c.(349-351)tCg>tTg	p.S117L	ATP6V0E2_ENST00000425642.2_3'UTR|ATP6V0E2_ENST00000606024.1_Missense_Mutation_p.S68L|ATP6V0E2_ENST00000456496.2_3'UTR|ATP6V0E2_ENST00000479613.1_Missense_Mutation_p.S91L|ATP6V0E2_ENST00000495408.1_3'UTR	NM_001100592.1	NP_001094062.1	Q8NHE4	VA0E2_HUMAN	ATPase, H+ transporting V0 subunit e2	63					ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuole	ATPase activity, coupled to transmembrane movement of ions|hydrogen ion transmembrane transporter activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00256)			ACAACCCCTTCGTCCGGACCC	0.622000													9	17					0	0	1	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545613	234545613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:234545613C>T	ENST00000344644.5	+	1	514	c.445C>T	c.(445-447)Cct>Tct	p.P149S	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Missense_Mutation_p.P149S	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTTTCTGGATCCTTTTGATAC	0.383000													72	144					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47506911	47506911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47506911G>A	ENST00000285039.7	-	9	1258	c.959C>T	c.(958-960)tCc>tTc	p.S320F		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	320	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CATCTGATGGGACTCTTTCAC	0.393000													12	48					0	0	1	0	0
TMEM201	199953	broad.mit.edu	37	1	9661297	9661297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9661297C>T	ENST00000340305.5	+	5	750	c.741C>T	c.(739-741)ccC>ccT	p.P247P	TMEM201_ENST00000340381.6_Silent_p.P247P|TMEM201_ENST00000377376.4_Silent_p.P247P	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	247						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		CCACTGTGCCCCTGGCCCTGC	0.692000													8	91					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17444716	17444716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17444716G>A	ENST00000400588.1	-	9	1587	c.1480C>T	c.(1480-1482)Ccg>Tcg	p.P494S		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	494										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCAGATGCCGGGTTCTGCTGT	0.592000													15	44					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74976528	74976528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:74976528G>A	ENST00000261978.4	-	21	3572	c.3186C>T	c.(3184-3186)ccC>ccT	p.P1062P	LTBP2_ENST00000556690.1_Silent_p.P1062P	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1062	Cys-rich.|EGF-like 9; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGAGGCCTGTGGGGCATGAGG	0.592000													12	145					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	166958581	166958581	+	Nonstop_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:166958581T>A	ENST00000392766.2	-	21	2743	c.2403A>T	c.(2401-2403)taA>taT	p.*801Y	ZBBX_ENST00000392764.1_Nonstop_Mutation_p.*772Y|ZBBX_ENST00000455345.2_Nonstop_Mutation_p.*840Y|ZBBX_ENST00000392767.2_Nonstop_Mutation_p.*801Y|ZBBX_ENST00000307529.5_Nonstop_Mutation_p.*840Y	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	0						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CAAATAATCTTTAAGTACTCT	0.388000													34	90					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21309123	21309123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21309123G>A	ENST00000417816.2	-	3	525	c.172C>T	c.(172-174)Ccg>Tcg	p.P58S	NEBL_ENST00000377159.4_Missense_Mutation_p.P24S	NM_001173484.1|NM_213569.2	NP_001166955.1|NP_998734.1	O76041	NEBL_HUMAN	nebulette	720				RYKEEFKK -> VIKKSLKS (in Ref. 2; AAF24858).	regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GACTGCTTCGGGTAGTGTCTG	0.413000													8	104					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154861319	154861319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:154861319C>T	ENST00000460393.1	+	13	1396	c.1276C>T	c.(1276-1278)Ctt>Ttt	p.L426F	MME_ENST00000462745.1_Missense_Mutation_p.L426F|MME_ENST00000493237.1_Missense_Mutation_p.L426F|MME_ENST00000492661.1_Missense_Mutation_p.L426F|MME_ENST00000360490.2_Missense_Mutation_p.L426F	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	426					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TGTGGGGAGGCTTTATGTGGA	0.413000													55	142					0	0	1	0	0
ARMC4P1	101060171	broad.mit.edu	37	10	27552006	27552006	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27552006G>A	ENST00000576034.1	+	0	262																											CCCTCTAAATGAAGTGATATT	0.438000													20	39					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29420417	29420417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29420417G>A	ENST00000389048.3	-	27	4970	c.4064C>T	c.(4063-4065)cCt>cTt	p.P1355L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1355	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CACAGGCCCAGGGCAGTTCTT	0.438000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome		OREG0014526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	82					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70144128	70144128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:70144128C>T	ENST00000370958.1	+	2	257	c.67C>T	c.(67-69)Cgt>Tgt	p.R23C	LRRC7_ENST00000310961.5_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	0						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TAAAGAGGTTCGTGCAGCACT	0.403000													8	10					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501770	140501770	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140501770C>A	ENST00000194152.1	+	1	190	c.190C>A	c.(190-192)Cgg>Agg	p.R64R		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		64	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGTCAGCCCGGGTGCTGTC	0.567000													22	68					7.41877e-09	7.44479e-09	1	1	0
LY86	9450	broad.mit.edu	37	6	6649878	6649878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:6649878C>T	ENST00000379953.2	+	5	725	c.373C>T	c.(373-375)Cct>Tct	p.P125S	LY86_ENST00000230568.4_Missense_Mutation_p.P125S			O95711	LY86_HUMAN	lymphocyte antigen 86	125					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane				large_intestine(2)|lung(6)	8	Ovarian(93;0.0377)					CTATGCTGGGCCTGTCAATAA	0.299000													28	57					0	0	1	0	0
STAU1	6780	broad.mit.edu	37	20	47752396	47752396	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47752396T>C	ENST00000371828.3	-	6	827	c.340A>G	c.(340-342)Aaa>Gaa	p.K114E	STAU1_ENST00000371792.1_Missense_Mutation_p.K114E|STAU1_ENST00000371856.2_Missense_Mutation_p.K195E|STAU1_ENST00000371802.1_Missense_Mutation_p.K114E|STAU1_ENST00000360426.4_Missense_Mutation_p.K114E|STAU1_ENST00000340954.7_Missense_Mutation_p.K114E|STAU1_ENST00000347458.5_Missense_Mutation_p.K114E	NM_001037328.1|NM_004602.2	NP_001032405.1|NP_004593.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	195	DRBM 1.					microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			AAGTTCCGTTTAAGTGCAATC	0.328000													20	50					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47976805	47976805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47976805C>T	ENST00000543600.1	-	2	460	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	PTCHD4_ENST00000339488.4_Missense_Mutation_p.E158K			Q6ZW05	CF138_HUMAN	patched domain containing 4	158						integral to membrane	hedgehog receptor activity										TTTGGCACTTCCACTACCCCG	0.483000													10	28					0	0	1	0	0
GCA	25801	broad.mit.edu	37	2	163213409	163213409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163213409C>T	ENST00000437150.2	+	5	609	c.448C>T	c.(448-450)Ctt>Ttt	p.L150F	GCA_ENST00000233612.4_Missense_Mutation_p.L131F|GCA_ENST00000429691.2_Intron	NM_012198.3	NP_036330.1	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	150	EF-hand 3.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	9						AGCCATTGGTCTTATGGGTAA	0.363000													6	96					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51863539	51863539	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:51863539G>A	ENST00000453097.2	+	12	1708	c.1491G>A	c.(1489-1491)ggG>ggA	p.G497G	SLC4A8_ENST00000394856.1_Silent_p.G444G|SLC4A8_ENST00000358657.3_Silent_p.G524G|SLC4A8_ENST00000514353.3_Silent_p.G444G|SLC4A8_ENST00000546663.1_3'UTR|SLC4A8_ENST00000535225.2_Silent_p.G444G	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	497					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TCACCTTTGGGGGACTGCTTG	0.502000													15	104					0	0	1	0	0
KDM7A	80853	broad.mit.edu	37	7	139801824	139801824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139801824G>A	ENST00000397560.2	-	12	1662	c.1565C>T	c.(1564-1566)cCt>cTt	p.P522L	JHDM1D_ENST00000006967.5_Missense_Mutation_p.P522L	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		522					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					TAGGTTAGAAGGAGTTCGGAC	0.433000													38	165					0	0	1	0	0
PROCR	10544	broad.mit.edu	37	20	33764245	33764245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33764245G>A	ENST00000216968.4	+	3	679	c.597G>A	c.(595-597)acG>acA	p.T199T	EDEM2_ENST00000540582.1_Intron	NM_006404.3	NP_006395.2	Q9UNN8	EPCR_HUMAN	protein C receptor, endothelial	199					antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity			breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	CGGAAAACACGAAAGGTATGA	0.547000													28	70					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126242399	126242399	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126242399G>A	ENST00000394329.3	+	1	4846	c.4833G>A	c.(4831-4833)agG>agA	p.R1611R		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1611	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTGAAAGGAGGAAATCGACCA	0.438000													42	122					0	0	1	0	0
CDC42EP4	23580	broad.mit.edu	37	17	71281633	71281633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:71281633G>A	ENST00000335793.3	-	2	1401	c.1007C>T	c.(1006-1008)tCa>tTa	p.S336L	CDC42EP4_ENST00000439510.2_Missense_Mutation_p.S266L|CDC42EP4_ENST00000581014.1_Silent_p.L68L			Q9H3Q1	BORG4_HUMAN	CDC42 effector protein (Rho GTPase binding) 4	336					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(7)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			TGGCTGTCTTGAGACAGCAGC	0.647000													33	63					0	0	1	0	0
DENND2D	79961	broad.mit.edu	37	1	111741362	111741362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111741362C>T	ENST00000357640.4	-	3	475	c.246G>A	c.(244-246)cgG>cgA	p.R82R	DENND2D_ENST00000369752.5_Silent_p.R79R|DENND2D_ENST00000473682.1_5'UTR	NM_024901.3	NP_079177.2	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	82	UDENN.									breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		GCAGGTTCTCCCGCTATAAGG	0.557000													13	43					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91755509	91755509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91755509G>A	ENST00000389857.6	-	25	4467	c.4381C>T	c.(4381-4383)Ccc>Tcc	p.P1461S		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1461					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CCCAGTGCGGGGGTGTCGGGG	0.697000													29	54					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28229561	28229561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28229561C>T	ENST00000305242.5	-	13	2009	c.1917G>A	c.(1915-1917)cgG>cgA	p.R639R	ARMC4_ENST00000537576.1_Silent_p.R331R|ARMC4_ENST00000545014.1_Silent_p.R164R	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	639							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TCTTCAGCAGCCGAGCCAACA	0.527000													44	112					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141315179	141315179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141315179C>T	ENST00000325617.5	-	11	1606	c.1166G>A	c.(1165-1167)cGa>cAa	p.R389Q	CLGN_ENST00000414773.1_Missense_Mutation_p.R389Q|CLGN_ENST00000537281.1_Missense_Mutation_p.R389Q	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	389					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					AGGAATTTTTCGAGGACTCCA	0.343000													18	47					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86947982	86947982	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86947982C>T	ENST00000234701.3	+	6	1003	c.652C>T	c.(652-654)Ctc>Ttc	p.L218F	CLCA1_ENST00000394711.1_Missense_Mutation_p.L218F			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	218					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		AGTAACAGGACTCTATGAAAA	0.403000													5	87					0	0	1	0	0
RBMY2EP	159125	broad.mit.edu	37	Y	23557655	23557655	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:23557655C>T	ENST00000444169.1	-	0	320					NR_001574.2																						CCACGGGTTTCGTCGTAGCCA	0.299000													6	2					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14157366	14157366	+	Silent	SNP	G	G	A	rs140727303		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:14157366G>A	ENST00000263379.2	+	8	1202	c.1077G>A	c.(1075-1077)ggG>ggA	p.G359G		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	359	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						CTCGAGATGGGGACCCCCTGG	0.642000													31	100					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64428396	64428396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64428396C>T	ENST00000265459.6	-	10	2475	c.2014G>A	c.(2014-2016)Ggc>Agc	p.G672S	NRXN2_ENST00000377551.1_Missense_Mutation_p.G672S|NRXN2_ENST00000409571.1_Missense_Mutation_p.G665S|NRXN2_ENST00000377559.3_Missense_Mutation_p.G641S|NRXN2_ENST00000496291.1_5'UTR	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	672	Laminin G-like 3.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TCAGCCAGGCCCCGGAGGTCT	0.682000													23	33					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152586	18152586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18152586C>T	ENST00000375406.1	+	3	889	c.673C>T	c.(673-675)Cgt>Tgt	p.R225C		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	225						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CCTGGACTTTCGTGAGAGGCA	0.597000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	75					0	0	1	0	0
FAXC	84553	broad.mit.edu	37	6	99797051	99797051	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:99797051G>A	ENST00000389677.5	-	1	480	c.198C>T	c.(196-198)acC>acT	p.T66T		NM_032511.2	NP_115900.1	Q5TGI0	CF168_HUMAN	failed axon connections homolog (Drosophila)	66																	TCAAGTAAAGGGTTTTCTTCC	0.597000													26	46					0	0	1	0	0
POLI	11201	broad.mit.edu	37	18	51818291	51818291	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:51818291C>T	ENST00000579534.1	+	9	1430	c.1287C>T	c.(1285-1287)acC>acT	p.T429T	POLI_ENST00000582366.1_3'UTR|POLI_ENST00000217800.5_Silent_p.T303T|POLI_ENST00000579434.1_Silent_p.T326T|POLI_ENST00000406285.3_Silent_p.T350T	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	429					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		TTCACCTTACCCTTCTAAGTG	0.338000								DNA polymerases (catalytic subunits)					17	70					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23517527	23517527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23517527C>T	ENST00000397359.3	-	13	2381	c.2122G>A	c.(2122-2124)Ggg>Agg	p.G708R	CDH24_ENST00000485922.1_5'UTR|CDH24_ENST00000267383.5_Missense_Mutation_p.G708R|CDH24_ENST00000554034.1_Missense_Mutation_p.G670R|CDH24_ENST00000487137.2_Missense_Mutation_p.G670R	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	708					adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		ggggccgccccgTCCGGGTTC	0.761000													45	87					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897363	153897363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:153897363C>T	ENST00000511601.1	+	12	3108	c.2920C>T	c.(2920-2922)Ccc>Tcc	p.P974S	FHDC1_ENST00000260008.3_Missense_Mutation_p.P974S			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	974					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GAGGGACGTTCCCCTGCAGCC	0.662000													16	32					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54872709	54872709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54872709G>A	ENST00000391743.3	-	2	404	c.124C>T	c.(124-126)Ctg>Ttg	p.L42L	LAIR1_ENST00000391742.2_Silent_p.L60L|LAIR1_ENST00000474878.1_Silent_p.L59L|LAIR1_ENST00000434277.2_Silent_p.L59L|LAIR1_ENST00000313038.6_Silent_p.L53L|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000348231.4_Silent_p.L60L			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	60	Ig-like C2-type.					integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		TCCCTCTCCAGGCGGAATGTT	0.562000													64	150					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080850	54080850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54080850G>A	ENST00000253144.9	+	7	2369	c.1036G>A	c.(1036-1038)Gag>Aag	p.E346K	ZNF331_ENST00000512387.1_Missense_Mutation_p.E346K|ZNF331_ENST00000511593.2_Missense_Mutation_p.E346K|ZNF331_ENST00000511154.1_Missense_Mutation_p.E346K|ZNF331_ENST00000449416.1_Missense_Mutation_p.E346K|ZNF331_ENST00000513265.1_3'UTR|ZNF331_ENST00000513999.1_Missense_Mutation_p.E346K|ZNF331_ENST00000411977.2_Missense_Mutation_p.E346K	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E346K(1)		NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		CGTTAAGCACGAGAGGATACA	0.527000			T	?	follicular thyroid adenoma								21	51					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40790001	40790001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40790001C>T	ENST00000373198.3	-	18	2974	c.2739G>A	c.(2737-2739)gaG>gaA	p.E913E	PTPRT_ENST00000373187.1_Silent_p.E891E|PTPRT_ENST00000373193.3_Silent_p.E894E|PTPRT_ENST00000373201.1_Silent_p.E881E|PTPRT_ENST00000373184.1_Silent_p.E881E|PTPRT_ENST00000356100.2_Silent_p.E900E|PTPRT_ENST00000373190.1_Silent_p.E890E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	891	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTCGTATTCCTCCTTGAACC	0.552000													30	61					0	0	1	0	0
ZBTB34	403341	broad.mit.edu	37	9	129641745	129641745	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:129641745C>T	ENST00000319119.4	+	2	152	c.67C>T	c.(67-69)Ctg>Ttg	p.L23L	ZBTB34_ENST00000373452.2_Silent_p.L19L	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						CAGCACCGTTCTGAGCCAGCT	0.507000													30	97					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35506399	35506399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35506399C>T	ENST00000217320.3	+	2	175	c.131C>T	c.(130-132)cCc>cTc	p.P44L	TLDC2_ENST00000602922.1_Missense_Mutation_p.P44L	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		CCTGAGGATCCCACGGTGCCC	0.607000													21	73					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30605092	30605092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30605092G>A	ENST00000358107.4	-	8	1656	c.1657C>T	c.(1657-1659)Cgt>Tgt	p.R553C	MTPAP_ENST00000263063.3_Missense_Mutation_p.R423C|MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	423					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						CTCAAGTCACGAACAAATGTG	0.343000													12	39					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198469	170198469	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170198469C>T	ENST00000231706.4	-	7	1917	c.1602G>A	c.(1600-1602)aaG>aaA	p.K534K	CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	534						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CAATCAGCTTCTTTAACTTGA	0.507000													39	100					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207103749	207103749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207103749C>T	ENST00000356495.4	-	11	2392	c.2209G>A	c.(2209-2211)Gag>Aag	p.E737K		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	737						extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TCGGCTTCCTCCTTGGATGAC	0.627000													8	34					0	0	1	0	0
LOC344967	344967	broad.mit.edu	37	4	40045328	40045328	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40045328C>T	ENST00000381811.2	-	0	821					NR_027277.1																						TGGCCCTCCTCCTCCTGCTCC	0.597000													15	25					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389379	4389379	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4389379G>A	ENST00000408920.2	-	1	237	c.147C>T	c.(145-147)ttC>ttT	p.F49F		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGGATAATGAAGATGAGCA	0.532000													13	28					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121478834	121478834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121478834G>A	ENST00000260197.7	+	38	5317	c.5188G>A	c.(5188-5190)Gga>Aga	p.G1730R	SORL1_ENST00000527934.1_Missense_Mutation_p.G345R|SORL1_ENST00000525532.1_Missense_Mutation_p.G674R|SORL1_ENST00000532694.1_Missense_Mutation_p.G576R|SORL1_ENST00000534286.1_Missense_Mutation_p.G640R	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1730	Fibronectin type-III 2.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GACTAGTCGTGGAATAGGAAA	0.373000													23	58					0	0	1	0	0
ACTR3	10096	broad.mit.edu	37	2	114670797	114670797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:114670797C>T	ENST00000536059.1	+	2	263	c.32C>T	c.(31-33)tCc>tTc	p.S11F	ACTR3_ENST00000263238.2_Silent_p.I31I|ACTR3_ENST00000535589.2_5'UTR			P61158	ARP3_HUMAN	ARP3 actin-related protein 3 homolog (yeast)	0					cellular component movement|cilium morphogenesis	Arp2/3 protein complex	actin binding|ATP binding			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(2)	15						AGTTTATCATCCCTTCCTGTA	0.294000													24	71					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774551	40774551	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:40774551A>T	ENST00000602553.1	-	5	1018	c.724T>A	c.(724-726)Tcc>Acc	p.S242T	ZNF658_ENST00000377626.3_Missense_Mutation_p.S242T|ZNF658_ENST00000441795.1_Missense_Mutation_p.S240T			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCCTTACAGGACTTTTCTCCT	0.328000													24	90					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16351295	16351295	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16351295C>T	ENST00000375692.1	+	5	395	c.267C>T	c.(265-267)caC>caT	p.H89H	CLCNKA_ENST00000331433.4_Silent_p.H89H|CLCNKA_ENST00000439316.2_Intron|CLCNKA_ENST00000464764.1_Intron|CLCNKA_ENST00000420078.1_Silent_p.H89H			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	89					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GGGACAGCCACCTGCTCCGGT	0.622000													21	52					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97919993	97919993	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:97919993C>T	ENST00000534948.1	+	0	4771							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AAGGCAAAACCTGAAGATGTC	0.383000													12	24					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127671201	127671201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127671201C>T	ENST00000508053.1	-	35	4767	c.3793G>A	c.(3793-3795)Gaa>Aaa	p.E1265K	FBN2_ENST00000507835.1_Missense_Mutation_p.E115K|FBN2_ENST00000262464.4_Missense_Mutation_p.E1265K|FBN2_ENST00000508989.1_Missense_Mutation_p.E1232K			P35556	FBN2_HUMAN	fibrillin 2	1265	EGF-like 19; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CAGCTGCATTCGTAGCTTCCC	0.433000													70	165					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42583205	42583205	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42583205C>A	ENST00000600245.1	+	2	1102	c.447C>A	c.(445-447)ctC>ctA	p.L149L	ZNF574_ENST00000359044.4_Silent_p.L149L|CTB-59C6.3_ENST00000594531.1_RNA|ZNF574_ENST00000222339.7_Silent_p.L239L			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				AGACGCACCTCCGGGCCACAC	0.642000													47	77					6.23363e-37	6.27773e-37	1	1	0
C6	729	broad.mit.edu	37	5	41203238	41203238	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41203238C>T	ENST00000263413.3	-	2	359	c.95G>A	c.(94-96)tGg>tAg	p.W32*	C6_ENST00000337836.5_Nonsense_Mutation_p.W32*	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	32	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCAGCTGGTCCACTGAGTCCA	0.507000													22	244					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934633	28934633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28934633C>T	ENST00000257192.4	+	15	2686	c.2474C>T	c.(2473-2475)cCt>cTt	p.P825L	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG1_ENST00000462981.2_Missense_Mutation_p.P184L|RP11-534N16.1_ENST00000581856.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	825					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CATCCTAAGCCTATTCTCGAT	0.517000													67	164					0	0	1	0	0
PNMT	5409	broad.mit.edu	37	17	37826205	37826205	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37826205G>A	ENST00000269582.2	+	3	730	c.410_splice	c.e3-1	p.E138_splice	PNMT_ENST00000394246.1_Splice_Site_p.E40_splice|PNMT_ENST00000581428.1_3'UTR	NM_002686.3	NP_002677.1	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	138					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			NS(1)|breast(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCTGCACAGGGAATGCTGGCA	0.652000													8	51					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123019002	123019002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123019002G>A	ENST00000462833.1	-	15	4077	c.2865C>T	c.(2863-2865)ttC>ttT	p.F955F	ADCY5_ENST00000309879.5_Silent_p.F605F|ADCY5_ENST00000491190.1_Silent_p.F588F	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	955					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CGGCGTTGTCGAAGAGCGTGA	0.617000													14	52					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20443765	20443765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20443765C>T	ENST00000305051.5	+	1	163	c.88C>T	c.(88-90)Cat>Tat	p.H30Y		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGAGACAAATCATTCTCGGGT	0.388000													56	107					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69816835	69816835	+	Missense_Mutation	SNP	G	G	A	rs138523993		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69816835G>A	ENST00000251566.4	-	1	674	c.644C>T	c.(643-645)tCa>tTa	p.S215L	UGT2A3_ENST00000420231.2_5'UTR	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	215						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GAACAAAACTGAAAGCATTGA	0.358000													9	47					0	0	1	0	0
MAPK8IP2	23542	broad.mit.edu	37	22	51043813	51043813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:51043813C>T	ENST00000399908.2	+	4	1701	c.985C>T	c.(985-987)Ctt>Ttt	p.L329F	MAPK8IP2_ENST00000329492.3_Missense_Mutation_p.L594F|MAPK8IP2_ENST00000341339.4_Missense_Mutation_p.L215F|MAPK8IP2_ENST00000008876.5_Missense_Mutation_p.L300F|MAPK8IP2_ENST00000399912.1_Missense_Mutation_p.L329F|MAPK8IP2_ENST00000442429.2_Missense_Mutation_p.L317F	NM_016431.3	NP_057515.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	595					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTCCTTTGGCCTTTTCTCCTG	0.647000													6	38					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96104083	96104083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:96104083C>T	ENST00000453304.1	-	14	2764	c.2416G>A	c.(2416-2418)Ggg>Agg	p.G806R		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	806					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AAGATCTGCCCTTCTCCTTCC	0.522000													31	79					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169756	57169756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57169756G>A	ENST00000371244.4	+	7	967	c.901G>A	c.(901-903)Gaa>Aaa	p.E301K		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	301					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TGAAAAATTTGAATGTACAGA	0.373000													15	232					0	0	1	0	0
NEDD4	4734	broad.mit.edu	37	15	56207630	56207630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:56207630G>A	ENST00000508342.1	-	1	1699	c.1400C>T	c.(1399-1401)tCc>tTc	p.S467F	NEDD4_ENST00000506154.1_Missense_Mutation_p.S467F|NEDD4_ENST00000435532.3_Intron|NEDD4_ENST00000338963.2_Missense_Mutation_p.S467F			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	467					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		GGATAGACAGGAAATATTTGG	0.358000													42	121					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27537457	27537457	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27537457C>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							AGATATGGATCTTCAACAGTT	0.383000													42	146					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33031217	33031217	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:33031217G>A	ENST00000340811.4	-	3	705	c.597C>T	c.(595-597)atC>atT	p.I199I	PKP2_ENST00000070846.6_Silent_p.I199I	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	199					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding	p.I199I(1)		NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGACCCCCACGATCTCGGAAC	0.597000													18	53					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30948420	30948420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30948420C>T	ENST00000298139.5	+	15	2040	c.1791C>T	c.(1789-1791)ccC>ccT	p.P597P		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	597	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TTATCTCTCCCCTTATTTCTC	0.358000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				25	134					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53233753	53233753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53233753C>T	ENST00000359499.4	-	7	744	c.733G>A	c.(733-735)Gcc>Acc	p.A245T	KRT78_ENST00000304620.4_Missense_Mutation_p.A355T			Q8N1N4	K2C78_HUMAN	keratin 78	355	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						GTGATGGCGGCCTGCAGGCTG	0.582000													14	27					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29226487	29226487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29226487C>T	ENST00000379558.4	+	6	1120	c.769C>T	c.(769-771)Ctt>Ttt	p.L257F	FAM179A_ENST00000403861.2_Missense_Mutation_p.L257F	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	257							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GCCTGGCTCCCTTCCCAGCCC	0.622000													5	13					0	0	1	0	0
C5orf20	140947	broad.mit.edu	37	5	134782660	134782660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134782660C>T	ENST00000503143.2	-	1	378	c.139G>A	c.(139-141)Gag>Aag	p.E47K	TIFAB_ENST00000537858.1_3'UTR	NM_130848.2	NP_570900.1	Q8TF63	DCNP1_HUMAN	chromosome 5 open reading frame 20	47						nucleus				endometrium(1)|lung(1)|prostate(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCAAAGTTCTCTGGTGGAGCT	0.612000													4	19					0	0	1	0	0
ZNF174	7727	broad.mit.edu	37	16	3454615	3454615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3454615C>T	ENST00000268655.4	+	2	1177	c.592C>T	c.(592-594)Ctc>Ttc	p.L198F	ZNF174_ENST00000344823.5_Missense_Mutation_p.L198F|ZNF174_ENST00000571936.1_Missense_Mutation_p.L198F|ZNF174_ENST00000572544.1_Missense_Mutation_p.L198F|ZNF174_ENST00000575752.1_Missense_Mutation_p.L198F|LA16c-306E5.2_ENST00000575785.1_RNA	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	198					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						ATCCCCACTCCTCCAAGAACC	0.532000													23	95					0	0	1	0	0
WSB1	26118	broad.mit.edu	37	17	25630396	25630396	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:25630396C>T	ENST00000262394.2	+	3	529	c.213C>T	c.(211-213)ctC>ctT	p.L71L	WSB1_ENST00000579733.1_Intron|WSB1_ENST00000348811.2_Intron|WSB1_ENST00000583193.1_Intron|WSB1_ENST00000581185.1_Silent_p.L71L|WSB1_ENST00000578312.1_3'UTR|WSB1_ENST00000427287.2_Silent_p.L40L	NM_015626.8	NP_056441.6	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box containing 1	71					intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		ACTCCAGTCTCTTGCATGGCA	0.368000													44	65					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86896591	86896591	+	Silent	SNP	C	C	T	rs147947036	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86896591C>T	ENST00000370565.4	+	4	684	c.522C>T	c.(520-522)ttC>ttT	p.F174F		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	174					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		GGGGTGTGTTCGATGAGTATA	0.373000													50	105					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100700	168100700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:168100700G>A	ENST00000409195.1	+	9	2887	c.2798G>A	c.(2797-2799)cGa>cAa	p.R933Q	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R933Q|XIRP2_ENST00000409273.1_Missense_Mutation_p.R711Q|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	758					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAGTACACACGAACAGTGAAA	0.333000													25	51					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99438711	99438711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99438711C>T	ENST00000397899.2	-	7	2356	c.2025G>A	c.(2023-2025)ccG>ccA	p.P675P		NM_207362.2	NP_997245.2			KIAA1211-like									p.P675P(1)									TGTCCTCACTCGGGGCCGGCT	0.711000													8	12					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72992610	72992610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72992610C>T	ENST00000268489.5	-	2	2107	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	479	Poly-Glu.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				tcctcctcctcttcttcctcc	0.592000													10	50					0	0	1	0	0
GPR183	1880	broad.mit.edu	37	13	99948140	99948140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:99948140C>T	ENST00000376414.4	-	2	343	c.260G>A	c.(259-261)cGa>cAa	p.R87Q	UBAC2_ENST00000376440.2_Intron|UBAC2_ENST00000403766.3_Intron	NM_004951.4	NP_004942.1	P32249	GP183_HUMAN	G protein-coupled receptor 183	87					humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	23						GTAGGCTATTCGTGTAGGCAA	0.408000													40	81					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153864657	153864657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:153864657C>T	ENST00000511601.1	+	2	636	c.448C>T	c.(448-450)Cct>Tct	p.P150S	FHDC1_ENST00000260008.3_Missense_Mutation_p.P150S			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	150	FH2.				actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GTCTTCCCTTCCTAGGAGAGG	0.478000													28	81					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793286	17793286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17793286C>T	ENST00000379472.3	+	2	675	c.645C>T	c.(643-645)ttC>ttT	p.F215F	KCNC1_ENST00000265969.6_Silent_p.F215F	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	215						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						ACGAGCGCTTCAACCCCATCG	0.567000													38	84					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34079764	34079764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34079764C>T	ENST00000254466.6	-	1	133	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K	GAS2L2_ENST00000587565.1_Missense_Mutation_p.E36K	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	36	CH.				cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCCAGGTCTTCCTTCATGGCC	0.632000													31	45					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688681	55688681	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55688681G>A	ENST00000358433.2	-	1	335	c.336C>T	c.(334-336)ctC>ctT	p.L112L		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGGCAGCCAGGAGGTAAAACT	0.393000													31	57					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456634	5456634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5456634G>A	ENST00000222033.4	+	1	1209	c.1132G>A	c.(1132-1134)Ggc>Agc	p.G378S		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	378						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CTCCCTACCGGGCCACCGGCC	0.682000													29	96					0	0	1	0	0
PLBD1	79887	broad.mit.edu	37	12	14664469	14664469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14664469C>T	ENST00000240617.5	-	7	1673	c.1021G>A	c.(1021-1023)Gac>Aac	p.D341N		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	341					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						GAAAAGATGTCTGCCCACCTC	0.428000													62	148					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176992706	176992706	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176992706C>T	ENST00000367654.2	-	7	1285	c.1270_splice	c.e7-1	p.G424_splice	ASTN1_ENST00000424564.2_Splice_Site_p.G424_splice|ASTN1_ENST00000367657.3_Splice_Site_p.G424_splice|ASTN1_ENST00000361833.2_Splice_Site_p.G424_splice|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	424					cell migration|neuron cell-cell adhesion	integral to membrane		p.G424G(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TGAAGCGGCTCCCTGCAGGGT	0.552000													5	26					0	0	1	0	0
ZNF625	90589	broad.mit.edu	37	19	12256753	12256753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12256753C>T	ENST00000355738.1	-	4	629	c.280G>A	c.(280-282)Ggg>Agg	p.G94R	ZNF625-ZNF20_ENST00000430024.1_Intron|ZNF625_ENST00000439556.2_Missense_Mutation_p.G160R|ZNF625_ENST00000542938.1_Missense_Mutation_p.G94R|ZNF625_ENST00000455799.1_3'UTR			Q96I27	ZN625_HUMAN	zinc finger protein 625	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(4)|skin(2)	14						TAAGGTTTCCCCCCAGTGTGA	0.428000													18	148					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39228121	39228121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39228121C>T	ENST00000340369.3	-	2	3044	c.2816G>A	c.(2815-2817)aGt>aAt	p.S939N	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.S939N	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	939							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTGCAGGCCACTCAGGTCTCC	0.632000													19	61					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37974775	37974775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37974775G>A	ENST00000377707.3	-	3	1463	c.898C>T	c.(898-900)Cct>Tct	p.P300S	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	300	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GGTTCGTAAGGGGTGTCATAT	0.537000													28	54					0	0	1	0	0
TBX5	6910	broad.mit.edu	37	12	114841688	114841688	+	Missense_Mutation	SNP	C	C	T	rs145365553		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:114841688C>T	ENST00000310346.4	-	2	682	c.16G>A	c.(16-18)Gag>Aag	p.E6K	TBX5_ENST00000552726.1_5'UTR|TBX5_ENST00000405440.2_Missense_Mutation_p.E6K|TBX5_ENST00000349716.5_Intron|TBX5_ENST00000526441.1_Missense_Mutation_p.E6K	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	6					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.E6*(2)|p.E6K(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CCAAAGCCCTCGTCTGCGTCG	0.677000													9	37					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53668977	53668977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53668977G>A	ENST00000600412.1	-	2	686	c.571C>T	c.(571-573)Cat>Tat	p.H191Y	ZNF665_ENST00000396424.3_Missense_Mutation_p.H256Y			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TCTCCAGTATGAATTCTCTGA	0.398000													53	127					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39895244	39895244	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:39895244G>A	ENST00000373186.4	-	1	211	c.74C>T	c.(73-75)tCc>tTc	p.S25F	MOCS1_ENST00000373188.2_Intron|MOCS1_ENST00000308559.7_Intron|MOCS1_ENST00000432280.2_Intron|MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000340692.5_Intron|MOCS1_ENST00000373175.4_Intron|MOCS1_ENST00000425303.2_Missense_Mutation_p.S25F	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	24	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACCGGGCTGGGAAGAGGCACA	0.632000													9	13					0	0	1	0	0
TAF1C	9013	broad.mit.edu	37	16	84213612	84213612	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84213612G>A	ENST00000567759.1	-	13	1821	c.1639C>T	c.(1639-1641)Cct>Tct	p.P547S	TAF1C_ENST00000341690.6_Missense_Mutation_p.P453S|TAF1C_ENST00000378541.4_Missense_Mutation_p.P547S|TAF1C_ENST00000541676.1_Missense_Mutation_p.P454S|TAF1C_ENST00000570117.1_Missense_Mutation_p.P215S|TAF1C_ENST00000566732.1_Missense_Mutation_p.P521S	NM_005679.3	NP_005670.3	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	547					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						TCCAGCAGAGGAAATGCAGGG	0.652000													16	25					0	0	1	0	0
MAPK13	5603	broad.mit.edu	37	6	36099123	36099123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36099123C>T	ENST00000211287.4	+	2	457	c.195C>T	c.(193-195)ttC>ttT	p.F65F	MAPK13_ENST00000490334.1_3'UTR|MAPK13_ENST00000373761.6_Silent_p.F65F|MAPK13_ENST00000373759.1_5'UTR|MAPK13_ENST00000373766.5_Silent_p.F65F	NM_002754.4	NP_002745.1	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	65	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|prostate(2)|skin(1)	12						CCGAGATCTTCGCCAAGCGCG	0.662000													13	80					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2096748	2096748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:2096748C>T	ENST00000382203.1	+	20	3184	c.2975C>T	c.(2974-2976)tCt>tTt	p.S992F	SMARCA2_ENST00000382194.1_Missense_Mutation_p.S992F|SMARCA2_ENST00000349721.2_Missense_Mutation_p.S992F|SMARCA2_ENST00000357248.2_Missense_Mutation_p.S992F			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	992					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ACAGATGGTTCTGAGAAAGAT	0.448000													13	99					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44415468	44415468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44415468C>T	ENST00000372343.3	+	2	1126	c.464C>T	c.(463-465)tCa>tTa	p.S155L		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	155					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCTGAGGACTCACCAGTGGAT	0.617000													6	24					0	0	1	0	0
TSPYL1	7259	broad.mit.edu	37	6	116599704	116599704	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116599704C>T	ENST00000368608.3	-	1	1362	c.1290G>A	c.(1288-1290)agG>agA	p.R430R	DSE_ENST00000540275.1_Intron	NM_003309.3	NP_003300.1	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	430					nucleosome assembly	nucleolus				breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(3)|urinary_tract(1)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		ACCCAAAGGGCCTGGGGATCT	0.552000													15	49					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502631	20502631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20502631C>T	ENST00000315693.2	-	1	288	c.287G>A	c.(286-288)gGa>gAa	p.G96E		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GGAATAACATCCCCACCATGA	0.463000													30	60					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187509917	187509917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187509917G>A	ENST00000441802.2	-	27	13805	c.13596C>T	c.(13594-13596)gtC>gtT	p.V4532V		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4532					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GCATGCTCTCGACAGCGGGCG	0.557000										HNSCC(5;0.00058)			13	51					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152499804	152499804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152499804C>T	ENST00000427231.2	-	58	8222	c.8020G>A	c.(8020-8022)Gag>Aag	p.E2674K	NEB_ENST00000604864.1_Missense_Mutation_p.E2674K|NEB_ENST00000603639.1_Missense_Mutation_p.E2674K|NEB_ENST00000172853.10_Missense_Mutation_p.E2674K|NEB_ENST00000397345.3_Missense_Mutation_p.E2674K|NEB_ENST00000409198.1_Missense_Mutation_p.E2674K	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2674					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTCATCCTCGAGAGAACCA	0.408000													24	77					0	0	1	0	0
ENKUR	219670	broad.mit.edu	37	10	25273813	25273813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25273813C>T	ENST00000331161.4	-	5	835	c.616G>A	c.(616-618)Gag>Aag	p.E206K	ENKUR_ENST00000376363.1_Missense_Mutation_p.E206K	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	206						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						TTATGCACCTCTTCCCAGTTC	0.393000													19	48					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098663	144098663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:144098663G>A	ENST00000467773.1	-	4	319	c.320C>T	c.(319-321)gCt>gTt	p.A107V	NOBOX_ENST00000223140.5_Missense_Mutation_p.A22V|NOBOX_ENST00000483238.1_Missense_Mutation_p.A107V	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	107					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					GGGTCCTGCAGCCAGGGGCTT	0.607000													7	59					0	0	1	0	0
NCS1	23413	broad.mit.edu	37	9	132985378	132985378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:132985378C>T	ENST00000372398.3	+	6	500	c.414C>T	c.(412-414)ctC>ctT	p.L138L	NCS1_ENST00000458469.1_Silent_p.L120L	NM_014286.3	NP_055101.2	P62166	NCS1_HUMAN	neuronal calcium sensor 1	138					negative regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of neuron projection development	cell junction|Golgi cisterna membrane|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|protein binding			large_intestine(1)|lung(4)|stomach(1)	6						CCGTGGAGCTCCCAGAGGAGG	0.657000													11	41					0	0	1	0	0
PRSS50	29122	broad.mit.edu	37	3	46754528	46754528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46754528C>T	ENST00000460241.1	-	10	2454	c.784G>A	c.(784-786)Gag>Aag	p.E262K	PRSS50_ENST00000315170.7_Missense_Mutation_p.E262K			Q9UI38	TSP50_HUMAN	protease, serine, 50	262	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						ACTTCCTTCTCCTGAATGGTC	0.532000													81	189					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45430210	45430210	+	Missense_Mutation	SNP	G	G	A	rs138913762		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45430210G>A	ENST00000321429.4	+	11	1518	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	DUOX1_ENST00000389037.3_Missense_Mutation_p.E371K	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	371	Peroxidase-like; mediates peroxidase activity.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTGGAGCCGTGAGGTCCGAGC	0.537000													14	62					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17010355	17010355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17010355G>A	ENST00000443236.1	-	37	4951	c.4920C>T	c.(4918-4920)ctC>ctT	p.L1640L		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1593						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GCTTGTCAAGGAGCAGCTGCA	0.577000													15	42					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99798917	99798917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:99798917G>A	ENST00000259470.5	-	5	758	c.509C>T	c.(508-510)tCg>tTg	p.S170L	CTSV_ENST00000538255.1_Missense_Mutation_p.S170L	NM_001333.3	NP_001324.2			cathepsin V																		TTGAGGACGCGAACAGTCCAC	0.527000													24	77					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90077323	90077323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90077323C>T	ENST00000405460.2	+	65	13255	c.13159C>T	c.(13159-13161)Cgc>Tgc	p.R4387C	GPR98_ENST00000425867.2_Missense_Mutation_p.R48C	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4387					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTCCATTGTTCGCATCATAAT	0.363000													10	23					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204951123	204951123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204951123C>T	ENST00000367172.4	+	21	2773	c.2445C>T	c.(2443-2445)tcC>tcT	p.S815S	NFASC_ENST00000513543.1_Silent_p.S811S|NFASC_ENST00000338586.6_Silent_p.S815S|NFASC_ENST00000367169.4_Silent_p.S815S|NFASC_ENST00000360049.4_Silent_p.S811S|NFASC_ENST00000367171.4_Silent_p.S800S|NFASC_ENST00000401399.1_Silent_p.S815S|NFASC_ENST00000539706.1_Silent_p.S811S|NFASC_ENST00000367170.4_Silent_p.S815S|NFASC_ENST00000339876.6_Silent_p.S815S|NFASC_ENST00000404907.1_Silent_p.S811S|NFASC_ENST00000404076.1_Silent_p.S794S|NFASC_ENST00000338515.6_Silent_p.S815S			O94856	NFASC_HUMAN	neurofascin	815	Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGCCAGAGTCCGTCATCGGTT	0.622000													5	9					0	0	1	0	0
RNF6	6049	broad.mit.edu	37	13	26789042	26789042	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:26789042G>A	ENST00000381588.4	-	5	1729	c.977C>T	c.(976-978)tCc>tTc	p.S326F	RNF6_ENST00000346166.3_Missense_Mutation_p.S326F|RNF6_ENST00000399762.2_Intron|RNF6_ENST00000381570.3_Missense_Mutation_p.S326F|RNF6_ENST00000468480.1_Intron	NM_005977.3	NP_005968.1	Q9Y252	RNF6_HUMAN	ring finger protein (C3H2C3 type) 6	326	Arg-rich.				negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(3)|ovary(2)|prostate(2)|skin(2)	23	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		TTCCCTTTGGGAATTATGATA	0.413000													53	114					0	0	1	0	0
FAIM3	9214	broad.mit.edu	37	1	207095173	207095173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207095173G>A	ENST00000367091.3	-	1	170	c.27C>T	c.(25-27)taC>taT	p.Y9Y	FAIM3_ENST00000528654.1_5'UTR|FAIM3_ENST00000442471.2_Silent_p.Y9Y|FAIM3_ENST00000420007.2_Silent_p.Y9Y	NM_005449.4	NP_005440.1	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3	9					anti-apoptosis|cellular defense response	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(84;0.201)					CTGGCAGGAAGTAAAGTGGCC	0.507000													26	52					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701978	143701978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143701978G>A	ENST00000408922.2	+	1	957	c.889G>A	c.(889-891)Gaa>Aaa	p.E297K		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K296fs*1(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					AGAGGTCAAGGAAGCTCTGAA	0.433000													6	59					0	0	1	0	0
TMEM211	255349	broad.mit.edu	37	22	25331309	25331309	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25331309C>T	ENST00000407886.1	-	4	633	c.381G>A	c.(379-381)atG>atA	p.M127I	TMEM211_ENST00000423535.1_Missense_Mutation_p.M198I|TMEM211_ENST00000382744.1_Missense_Mutation_p.M127I			Q6ICI0	TM211_HUMAN	transmembrane protein 211	198						integral to membrane				endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						TTTATTTGTTCATTTCTGGCA	0.483000													40	101					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123600430	123600430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123600430G>A	ENST00000336139.4	-	4	868	c.506C>T	c.(505-507)tCg>tTg	p.S169L	ZNF202_ENST00000529691.1_Missense_Mutation_p.S169L|ZNF202_ENST00000530393.1_Missense_Mutation_p.S169L			O95125	ZN202_HUMAN	zinc finger protein 202	169					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CTCGGGGGTCGAGCTTTGCAC	0.597000													7	36					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317530	154317530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154317530C>T	ENST00000368489.3	+	22	2469	c.2469C>T	c.(2467-2469)acC>acT	p.T823T		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	809					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCCGGGTGACCCCCTTGCAGA	0.552000											OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	123					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71472148	71472148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71472148C>T	ENST00000322937.6	+	13	1148	c.1045C>T	c.(1045-1047)Ccc>Tcc	p.P349S	AMBN_ENST00000449493.2_Missense_Mutation_p.P334S	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	349					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			AGAACCTGCTCCCCACGCAGG	0.592000													7	40					0	0	1	0	0
DPF2	5977	broad.mit.edu	37	11	65113244	65113244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65113244C>T	ENST00000528416.1	+	7	878	c.745C>T	c.(745-747)Cct>Tct	p.P249S	DPF2_ENST00000532264.1_3'UTR|DPF2_ENST00000415073.2_Intron|DPF2_ENST00000252268.4_Missense_Mutation_p.P263S	NM_006268.4	NP_006259.1	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	249					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)	23						ACCACCCACTCCTGTTTCCCA	0.532000													18	43					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166892569	166892569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166892569C>T	ENST00000423058.2	-	16	3435	c.3418G>A	c.(3418-3420)Gaa>Aaa	p.E1140K	SCN1A_ENST00000409050.1_Missense_Mutation_p.E1112K|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.E1129K|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.E1140K	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1140						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTTTGCTTTCTTCCAGATCC	0.358000													33	116					0	0	1	0	0
POLR3D	661	broad.mit.edu	37	8	22107731	22107731	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22107731C>T	ENST00000397802.4	+	7	1280	c.1065C>T	c.(1063-1065)tcC>tcT	p.S355S	POLR3D_ENST00000306433.4_Silent_p.S355S			P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	355					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	13				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CTGCCTGCTCCTTCCTGCAGG	0.562000													17	41					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039962	31039962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:31039962C>T	ENST00000355537.3	+	4	3583	c.3436C>T	c.(3436-3438)Ccc>Tcc	p.P1146S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGAGGATGTCCCCATCCTGAT	0.552000													20	71					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134144055	134144055	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134144055G>A	ENST00000220616.4	+	46	7902		c.e46-1		TG_ENST00000542445.1_Splice_Site|TG_ENST00000519543.1_Splice_Site|TG_ENST00000377869.1_Splice_Site	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin						hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGTTTTCTCAGCCTGGAGCTG	0.463000													11	61					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25819833	25819833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:25819833G>A	ENST00000399878.3	-	9	1613	c.1491C>T	c.(1489-1491)ttC>ttT	p.F497F	SEL1L3_ENST00000502949.1_Silent_p.F344F|SEL1L3_ENST00000264868.5_Silent_p.F462F	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	497						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						TCTCCCAGGGGAAGGCTCTGC	0.552000													4	9					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49378993	49378993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49378993C>T	ENST00000200453.5	+	3	2057	c.1788C>T	c.(1786-1788)atC>atT	p.I596I		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	596					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		CACGCCGCATCACCCAGGCCC	0.726000													79	187					0	0	1	0	0
GALNTL5	168391	broad.mit.edu	37	7	151705022	151705022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151705022C>T	ENST00000392800.2	+	7	1273	c.1019C>T	c.(1018-1020)tCa>tTa	p.S340L	GALNTL5_ENST00000483959.1_3'UTR|GALNTL5_ENST00000431418.2_Missense_Mutation_p.S340L	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	340	Catalytic subdomain B.					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		TTGGAACTTTCACTAAGGGTA	0.328000													33	94					0	0	1	0	0
GALNT16	57452	broad.mit.edu	37	14	69818888	69818888	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:69818888G>A	ENST00000337827.4	+	15	2006		c.e15+1		GALNT16_ENST00000448469.3_3'UTR	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		ACACATGACGGTAGCCCTGGG	0.612000													6	18					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29044154	29044154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29044154C>T	ENST00000257189.4	+	9	1163	c.1080C>T	c.(1078-1080)atC>atT	p.I360I		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	360	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AATCAGTTATCTCTCGATACC	0.368000													24	60					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2795344	2795344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2795344C>T	ENST00000399655.1	+	45	5958	c.5693C>T	c.(5692-5694)tCc>tTc	p.S1898F	CACNA1C_ENST00000347598.4_Missense_Mutation_p.S1946F|CACNA1C_ENST00000399591.1_Missense_Mutation_p.S1906F|CACNA1C_ENST00000344100.3_Missense_Mutation_p.S1939F|CACNA1C_ENST00000399597.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000335762.5_Missense_Mutation_p.S1923F|CACNA1C_ENST00000399595.1_Missense_Mutation_p.S1906F|CACNA1C_ENST00000399603.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000399617.1_Missense_Mutation_p.S1933F|CACNA1C_ENST00000399606.1_Missense_Mutation_p.S1918F|CACNA1C_ENST00000399621.1_Missense_Mutation_p.S1917F|CACNA1C_ENST00000399601.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000399638.1_Missense_Mutation_p.S1926F|CACNA1C_ENST00000399649.1_Missense_Mutation_p.S1904F|CACNA1C_ENST00000399644.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000399629.1_Missense_Mutation_p.S1915F|CACNA1C_ENST00000327702.7_Missense_Mutation_p.S1933F|CACNA1C_ENST00000399634.1_Missense_Mutation_p.S1969F|CACNA1C_ENST00000399637.1_Missense_Mutation_p.S1917F|CACNA1C_ENST00000406454.3_Missense_Mutation_p.S1969F|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000402845.3_Missense_Mutation_p.S1917F|CACNA1C_ENST00000399641.1_Missense_Mutation_p.S1898F	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1981					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CGAAGGGCCTCCTTCCACCTG	0.582000													36	87					0	0	1	0	0
GALNTL5	168391	broad.mit.edu	37	7	151711762	151711762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151711762C>T	ENST00000392800.2	+	8	1314	c.1060C>T	c.(1060-1062)Ccc>Tcc	p.P354S	GALNTL5_ENST00000431418.2_Missense_Mutation_p.P354S	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	354	Catalytic subdomain B.					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		CTTTATAATCCCCTGCTCTCG	0.398000													34	96					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23885428	23885428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23885428C>T	ENST00000355349.3	-	34	4900	c.4738G>A	c.(4738-4740)Gac>Aac	p.D1580N		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1580					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ATCTCCTCGTCCTTCTCTGCC	0.642000													70	183					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61987410	61987410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:61987410G>A	ENST00000409186.1	-	5	2927	c.822C>T	c.(820-822)gtC>gtT	p.V274V	PCDH20_ENST00000409204.4_Silent_p.V274V			Q8N6Y1	PCD20_HUMAN	protocadherin 20	247	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AAGCACCCATGACAATTAGGT	0.527000													27	40					0	0	1	0	0
ZNF556	80032	broad.mit.edu	37	19	2876142	2876142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2876142C>T	ENST00000586426.1	+	3	269	c.182C>T	c.(181-183)tCt>tTt	p.S61F	ZNF556_ENST00000307635.2_Missense_Mutation_p.S61F			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGATACTTCTGGAGAAAAA	0.368000													53	191					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10419850	10419850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10419850G>A	ENST00000226207.5	-	3	204	c.110C>T	c.(109-111)tCa>tTa	p.S37L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	37	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CACAAAGACTGATGTCTTGGC	0.522000													20	175					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28547306	28547306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:28547306C>T	ENST00000357727.2	+	4	632	c.242C>T	c.(241-243)tCc>tTc	p.S81F	CREB5_ENST00000396300.2_Missense_Mutation_p.S74F|CREB5_ENST00000396299.2_Missense_Mutation_p.S48F|CREB5_ENST00000409603.1_Missense_Mutation_p.S48F	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	81					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						CTGGACTGCTCCCTGGAGCAC	0.552000													58	151					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22112104	22112104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:22112104C>T	ENST00000379374.4	+	7	1301	c.736C>T	c.(736-738)Cgg>Tgg	p.R246W	PHEX_ENST00000535894.1_Missense_Mutation_p.R149W|PHEX_ENST00000537599.1_Missense_Mutation_p.R246W|PHEX_ENST00000475778.1_3'UTR	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	246					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						CTTACAGTATCGGGATGCCCT	0.398000													69	36					0	0	1	0	0
GMEB2	26205	broad.mit.edu	37	20	62221711	62221711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62221711G>A	ENST00000266068.1	-	9	1802	c.1324C>T	c.(1324-1326)Ccc>Tcc	p.P442S	GMEB2_ENST00000370077.1_Missense_Mutation_p.P442S|GMEB2_ENST00000370069.1_Missense_Mutation_p.P391S			Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding protein 2	442					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	18	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			ACTGTGCTGGGGTAGGTGGAG	0.697000													9	25					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832614	61832614	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61832614C>T	ENST00000280772.1	-	37	8216	c.8025G>A	c.(8023-8025)aaG>aaA	p.K2675K	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2675					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGAGAACCATCTTCTCTGGGC	0.557000													25	79					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141536293	141536293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141536293C>T	ENST00000350549.3	-	5	981	c.610G>A	c.(610-612)Gga>Aga	p.G204R	PRSS37_ENST00000438520.1_Missense_Mutation_p.G204R	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	204	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						ACCTCGATTCCCTGGAGCTTG	0.498000													31	68					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4855892	4855892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4855892C>T	ENST00000399583.3	-	8	2120	c.1933G>A	c.(1933-1935)Ggg>Agg	p.G645R	RADIL_ENST00000536091.1_3'UTR|RADIL_ENST00000538469.1_Missense_Mutation_p.G405R	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	645	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		AGCAGTGTCCCGGAGAAGAAG	0.657000													9	39					0	0	1	0	0
METTL7B	196410	broad.mit.edu	37	12	56075728	56075728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56075728G>A	ENST00000394252.3	+	1	399	c.190G>A	c.(190-192)Ggg>Agg	p.G64R		NM_152637.2	NP_689850.2	Q6UX53	MET7B_HUMAN	methyltransferase like 7B	64							methyltransferase activity			kidney(1)|large_intestine(1)|lung(4)	6						CCAGATAAAGGGGCTTACAGG	0.592000													9	24					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83182714	83182714	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:83182714C>T	ENST00000398309.2	-	19	2556	c.2086G>A	c.(2086-2088)Gac>Aac	p.D696N	DLG2_ENST00000524982.1_Missense_Mutation_p.D692N|DLG2_ENST00000543673.1_Missense_Mutation_p.D801N|DLG2_ENST00000418306.2_Missense_Mutation_p.D575N|DLG2_ENST00000532653.1_Missense_Mutation_p.D678N|DLG2_ENST00000426717.2_Missense_Mutation_p.D160N|DLG2_ENST00000280241.8_Missense_Mutation_p.D735N|DLG2_ENST00000376106.3_Missense_Mutation_p.D160N|DLG2_ENST00000531015.1_Missense_Mutation_p.D663N|DLG2_ENST00000330014.6_Missense_Mutation_p.D617N|DLG2_ENST00000537455.1_Missense_Mutation_p.D446N|DLG2_ENST00000376104.2_Missense_Mutation_p.D801N|DLG2_ENST00000404783.3_Missense_Mutation_p.D174N	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	696	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GATATCAAGTCGTCATTGATC	0.428000													14	40					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838991	112838991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:112838991G>A	ENST00000280155.2	+	1	2202	c.1237G>A	c.(1237-1239)Gcc>Acc	p.A413T		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	398					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	CACGCTCACGGCCGTCGGGTG	0.582000													40	108					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6471258	6471258	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6471258G>A	ENST00000358945.3	-	3	1274	c.834C>T	c.(832-834)ttC>ttT	p.F278F	SCNN1A_ENST00000540037.1_5'UTR|SCNN1A_ENST00000396966.2_Silent_p.F278F|SCNN1A_ENST00000360168.3_Silent_p.F337F|SCNN1A_ENST00000228916.2_Silent_p.F278F|SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000543768.1_Silent_p.F301F			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	278					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	AGGCGAAGATGAAGTTGCCCA	0.622000													5	65					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80729743	80729743	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:80729743C>T	ENST00000458043.2	+	38	4402	c.4395_splice	c.e38-1	p.P1466_splice	OTOGL_ENST00000547103.1_Splice_Site_p.P1454_splice	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTATTAACAGCCTCAGAAATT	0.328000													7	42					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705578	101705578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:101705578C>T	ENST00000305352.6	+	2	1413	c.1038C>T	c.(1036-1038)gcC>gcT	p.A346A		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	346					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						CCATCATCGCCGGCATGGAAT	0.552000													10	184					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7989509	7989509	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7989509C>T	ENST00000319144.4	-	2	437	c.177G>A	c.(175-177)caG>caA	p.Q59Q		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	59	PLAT.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						CACCCAGGTCCTGAGGGCACT	0.632000										Multiple Myeloma(8;0.094)			5	26					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50592458	50592458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:50592458G>A	ENST00000442544.2	+	7	1799	c.1183G>A	c.(1183-1185)Gaa>Aaa	p.E395K	DCC_ENST00000580146.1_3'UTR|DCC_ENST00000581580.1_Missense_Mutation_p.E50K|DCC_ENST00000412726.1_Missense_Mutation_p.E243K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	395	Ig-like C2-type 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GAAGTCAGATGAAGGCTTTTA	0.443000													12	190					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90079864	90079864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90079864G>A	ENST00000405460.2	+	67	13739	c.13643G>A	c.(13642-13644)gGa>gAa	p.G4548E	GPR98_ENST00000425867.2_Missense_Mutation_p.G209E	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4548					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGACTCTTGGGAGAGATTCAG	0.363000													6	10					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168244307	168244307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168244307G>A	ENST00000519560.1	-	8	1210	c.791C>T	c.(790-792)cCa>cTa	p.P264L	SLIT3_ENST00000332966.8_Missense_Mutation_p.P264L|SLIT3_ENST00000404867.3_Missense_Mutation_p.P264L	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	264	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCCTCACCTGGGCACACGTA	0.572000													19	41					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145103957	145103957	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:145103957G>A	ENST00000453618.1	+	0	452							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										TAACTCTTTCGAAAGTTGAAT	0.393000													6	38					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133846313	133846313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:133846313G>A	ENST00000367895.5	+	19	2224	c.1760G>A	c.(1759-1761)cGa>cAa	p.R587Q	EYA4_ENST00000531901.1_Missense_Mutation_p.R593Q|EYA4_ENST00000355286.6_Missense_Mutation_p.R564Q|EYA4_ENST00000525849.1_Intron|EYA4_ENST00000355167.3_Intron|EYA4_ENST00000452339.2_Intron|RP3-323P13.2_ENST00000607033.1_RNA|EYA4_ENST00000431403.2_Intron|EYA4_ENST00000430974.2_Intron	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	587					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TGCTTTGAACGAATAATGCAA	0.408000													38	48					0	0	1	0	0
MT1F	4494	broad.mit.edu	37	16	56693046	56693046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:56693046G>A	ENST00000334350.6	+	3	521	c.156G>A	c.(154-156)ggG>ggA	p.G52G	MT1F_ENST00000394501.2_Silent_p.G53G|MT1F_ENST00000568475.1_3'UTR			P04733	MT1F_HUMAN	metallothionein 1F	52	Alpha.					cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding										TTTGCAAAGGGGCGTCAGAGA	0.527000													10	153					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048826	9048826	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9048826G>A	ENST00000397910.4	-	5	33008	c.32805C>T	c.(32803-32805)acC>acT	p.T10935T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10937	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGACCAGAGAGGTCACCACTC	0.498000													45	89					0	0	1	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61908562	61908562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:61908562C>T	ENST00000370275.4	+	5	440	c.348C>T	c.(346-348)gtC>gtT	p.V116V	ARFGAP1_ENST00000547204.1_Silent_p.V42V|ARFGAP1_ENST00000370283.4_Silent_p.V116V|ARFGAP1_ENST00000519273.2_Intron|ARFGAP1_ENST00000519604.1_Silent_p.V63V|ARFGAP1_ENST00000353546.3_Silent_p.V116V			Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	116	Arf-GAP.				COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					GTCAGGTGGTCGCTCTGGCCG	0.667000													10	21					0	0	1	0	0
HDAC7	51564	broad.mit.edu	37	12	48181838	48181838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48181838G>A	ENST00000080059.7	-	20	2344	c.2345C>T	c.(2344-2346)gCt>gTt	p.A782V	HDAC7_ENST00000427332.2_Missense_Mutation_p.A743V|HDAC7_ENST00000354334.3_Missense_Mutation_p.A745V|HDAC7_ENST00000552960.1_Missense_Mutation_p.A765V|HDAC7_ENST00000380610.4_Missense_Mutation_p.A799V	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	743	Histone deacetylase.				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		CTCATCCACAGCCCCACTCCC	0.572000													11	44					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	333251	333251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:333251G>A	ENST00000343164.4	-	11	1270	c.1218C>T	c.(1216-1218)taC>taT	p.Y406Y	SLC6A13_ENST00000445055.2_Silent_p.Y314Y|SLC6A13_ENST00000539668.1_5'UTR	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	406					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			ACACGTGAGGGTACATGTCCA	0.562000													14	42					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976098	20976098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20976098G>A	ENST00000261383.3	-	53	9107	c.9108C>T	c.(9106-9108)ttC>ttT	p.F3036F	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3036					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGAAGTCACTGAAGCCAGGGA	0.522000													17	40					0	0	1	0	0
SERINC3	10955	broad.mit.edu	37	20	43142617	43142617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43142617G>A	ENST00000342374.4	-	2	261	c.104C>T	c.(103-105)tCc>tTc	p.S35F	SERINC3_ENST00000255175.1_Missense_Mutation_p.S35F|SERINC3_ENST00000468234.1_5'UTR|SERINC3_ENST00000541235.1_5'UTR	NM_006811.2	NP_006802.1	Q13530	SERC3_HUMAN	serine incorporator 3	35						integral to membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(2)|lung(8)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			AGTCACCGTGGAATTCTTACT	0.478000													34	91					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99448865	99448865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:99448865C>T	ENST00000397899.2	-	5	817	c.486G>A	c.(484-486)agG>agA	p.R162R	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like																		CTGGGGGGCTCCTGGGCAGCC	0.617000													32	68					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143049044	143049044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143049044G>A	ENST00000343257.2	+	23	3040	c.2953G>A	c.(2953-2955)Gaa>Aaa	p.E985K		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	985					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GGATGAGGATGAACTGATCCT	0.617000													27	92					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6833918	6833918	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6833918G>A	ENST00000304076.2	+	19	1825		c.e19-1		VAV1_ENST00000596764.1_Splice_Site|VAV1_ENST00000539284.1_Splice_Site|VAV1_ENST00000599806.1_Splice_Site|VAV1_ENST00000602142.1_Splice_Site	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						TCTCCTTCCAGGACAAACTAC	0.537000													31	76					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5868478	5868478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:5868478G>A	ENST00000324989.7	-	2	475	c.387C>T	c.(385-387)gaC>gaT	p.D129D	CRMP1_ENST00000511535.1_5'UTR|CRMP1_ENST00000512574.1_Silent_p.D13D|CRMP1_ENST00000397890.2_Silent_p.D15D	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	15					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		TGAGGAGTCGGTCACTCTGCA	0.378000													14	51					0	0	1	0	0
CLEC4D	338339	broad.mit.edu	37	12	8673861	8673861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8673861G>A	ENST00000299665.2	+	6	835	c.642G>A	c.(640-642)ttG>ttA	p.L214L		NM_080387.4	NP_525126.2	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	214					innate immune response	integral to membrane	sugar binding			large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Lung SC(5;0.184)					GAACAACATTGAACTAGAAAC	0.363000													28	50					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29848108	29848108	+	Missense_Mutation	SNP	G	G	A	rs139726967		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29848108G>A	ENST00000399218.4	-	6	2409	c.2354C>T	c.(2353-2355)cCg>cTg	p.P785L	GAREM_ENST00000269209.6_Missense_Mutation_p.P786L	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1									p.P785L(1)									GAGATGGAGCGGAGATGAGAA	0.547000													20	34					0	0	1	0	0
TANGO6	79613	broad.mit.edu	37	16	68893950	68893950	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68893950C>T	ENST00000261778.1	+	2	270	c.258C>T	c.(256-258)aaC>aaT	p.N86N		NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		GGCCACAAAACTCTGTGGATG	0.433000													24	75					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678659	100678659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100678659C>T	ENST00000306151.4	+	3	4026	c.3962C>T	c.(3961-3963)cCt>cTt	p.P1321L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1321	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCTCCTACACCTGCTGAAGGT	0.473000													111	445					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785187	134785187	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134785187C>T	ENST00000537858.1	-	2	643	c.443G>A	c.(442-444)tGg>tAg	p.W148*		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	148										breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GATGCCTTCCCATTCGTCAGT	0.582000													32	75					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73489018	73489018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73489018C>T	ENST00000314256.7	+	16	2315	c.1921C>T	c.(1921-1923)Cct>Tct	p.P641S	KIAA0195_ENST00000579208.1_Missense_Mutation_p.P292S|KIAA0195_ENST00000375248.5_Missense_Mutation_p.P651S	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	641					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGCTTCACTCCTGGGGCCAA	0.607000													47	130					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110826801	110826801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110826801C>T	ENST00000375820.4	-	39	3519	c.3398G>A	c.(3397-3399)gGa>gAa	p.G1133E		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1133	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			ACCTGCTTCTCCTTTGACACC	0.547000													16	41					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784638	82784638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82784638G>A	ENST00000423517.2	-	2	1656	c.1319C>T	c.(1318-1320)cCa>cTa	p.P440L	PCLO_ENST00000333891.8_Missense_Mutation_p.P440L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	391	10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.|Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTGCTGAACTGGAGTCTTTGT	0.577000													22	114					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701687	56701687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56701687G>A	ENST00000586855.2	-	5	1310	c.997C>T	c.(997-999)Cat>Tat	p.H333Y	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.H333Y			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	333					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CCTGGGGAATGAACTGGATTG	0.547000													37	104					0	0	1	0	0
MYOZ3	91977	broad.mit.edu	37	5	150051192	150051192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150051192G>A	ENST00000297130.4	+	4	449	c.250G>A	c.(250-252)Gga>Aga	p.G84R	CTC-345K18.2_ENST00000511626.2_RNA|MYOZ3_ENST00000517768.1_Missense_Mutation_p.G84R	NM_001122853.2|NM_133371.4	NP_001116325.1|NP_588612.2	Q8TDC0	MYOZ3_HUMAN	myozenin 3	84	Binding to FLNC.					sarcomere	protein binding			large_intestine(2)|lung(1)|skin(2)	5		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAAGGTGACTGGAACAGCGGA	0.682000													13	121					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187004313	187004313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187004313C>T	ENST00000296795.2	+	4	1577	c.1473C>T	c.(1471-1473)gcC>gcT	p.A491A	TLR3_ENST00000504367.1_Silent_p.A214A	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	491					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		GAAGGGTGGCCCTTAAAAATG	0.448000													50	92					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39872801	39872801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39872801C>T	ENST00000502986.2	+	11	1185	c.943C>T	c.(943-945)Cct>Tct	p.P315S	IDO2_ENST00000389060.4_Missense_Mutation_p.P302S|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	302					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						TTACATGCCTCCTTCCCATAA	0.463000													25	58					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	47990425	47990425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:47990425C>T	ENST00000371741.4	-	2	1838	c.1672G>A	c.(1672-1674)Gaa>Aaa	p.E558K		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	558					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCAAGTTCTTCCTTTGGTTTG	0.493000													45	154					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6483644	6483644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6483644G>A	ENST00000358945.3	-	1	746	c.306C>T	c.(304-306)ttC>ttT	p.F102F	SCNN1A_ENST00000396966.2_Silent_p.F102F|SCNN1A_ENST00000360168.3_Silent_p.F161F|SCNN1A_ENST00000228916.2_Silent_p.F102F|SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000543768.1_Silent_p.F125F			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	102					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	AAAGCAGGCCGAATTGCCAGT	0.587000													9	68					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156816391	156816391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156816391G>A	ENST00000368195.3	-	8	2126	c.1730C>T	c.(1729-1731)gCc>gTc	p.A577V	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	577	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TAGCGTGATGGCCCGCACAAA	0.612000													18	38					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110463245	110463245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110463245G>A	ENST00000378402.5	+	41	6321	c.6217G>A	c.(6217-6219)Ggg>Agg	p.G2073R		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2073	IPT/TIG 13.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTGGTTAATGGGAAAGATTT	0.502000										HNSCC(38;0.096)	OREG0018931	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	27					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16376365	16376365	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16376365G>A	ENST00000375679.4	+	10	1033	c.922G>A	c.(922-924)Ggc>Agc	p.G308S	CLCNKB_ENST00000375667.3_Missense_Mutation_p.G139S	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		AATCTTCTTTGGCTTCATCAG	0.602000													73	139					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	51025755	51025755	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:51025755G>A	ENST00000442544.2	+	27	4602	c.3986G>A	c.(3985-3987)aGa>aAa	p.R1329K	DCC_ENST00000581580.1_Missense_Mutation_p.R962K|RP11-671P2.1_ENST00000582064.1_RNA	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1329					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCACCAAGCAGAACCATCCCC	0.542000													46	101					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594458	140594458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140594458G>A	ENST00000341948.4	+	1	950	c.763G>A	c.(763-765)Gac>Aac	p.D255N		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		255	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATCTCTGAGGACAGTCCGGT	0.498000													79	223					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16740758	16740758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:16740758C>T	ENST00000381323.3	-	10	1027	c.807G>A	c.(805-807)gtG>gtA	p.V269V	FAM49A_ENST00000406434.1_Silent_p.V269V|FAM49A_ENST00000355549.2_Silent_p.V269V	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	269						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			AGAAAGCTCCCACAGGGTGGA	0.468000													28	111					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107423438	107423438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107423438C>T	ENST00000340010.5	-	10	1404	c.1220G>A	c.(1219-1221)gGa>gAa	p.G407E	SLC26A3_ENST00000422236.2_Missense_Mutation_p.G372E	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	407					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TGTTTTGCCTCCTGTGCTCTC	0.468000													40	83					0	0	1	0	0
CSF2	1437	broad.mit.edu	37	5	131411475	131411475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131411475G>A	ENST00000296871.2	+	4	399	c.365G>A	c.(364-366)aGt>aAt	p.S122N		NM_000758.3	NP_000749.2	P04141	CSF2_HUMAN	colony stimulating factor 2 (granulocyte-macrophage)	122					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity			skin(1)	1		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	ACCTTTGAAAGTTTCAAAGAG	0.483000													21	196					0	0	1	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86491725	86491725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:86491725C>T	ENST00000395184.1	+	2	497	c.31C>T	c.(31-33)Ccc>Tcc	p.P11S	ARHGAP24_ENST00000506421.1_3'UTR|ARHGAP24_ENST00000503995.1_Missense_Mutation_p.P11S	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	11					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CACGGAGAACCCCCAACAAGG	0.468000													13	39					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8152010	8152010	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8152010G>A	ENST00000600128.1	-	54	7119	c.6705C>T	c.(6703-6705)gtC>gtT	p.V2235V	FBN3_ENST00000601739.1_Silent_p.V2235V|FBN3_ENST00000270509.2_Silent_p.V2235V			Q75N90	FBN3_HUMAN	fibrillin 3	2235	EGF-like 36; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CTGGGGGACAGACGCACGCGA	0.627000													15	59					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72169145	72169145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:72169145C>T	ENST00000555818.1	+	12	3917	c.3569C>T	c.(3568-3570)aCc>aTc	p.T1190I	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.T1190I|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.T1190I|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.T665I	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1190					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AGGCAGAACACCCAGTCAGAT	0.498000													28	49					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107642209	107642209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107642209G>A	ENST00000393561.1	-	1	263	c.79C>T	c.(79-81)Ccc>Tcc	p.P27S	LAMB1_ENST00000222399.6_Intron|LAMB1_ENST00000393560.1_Intron			P07942	LAMB1_HUMAN	laminin, beta 1	0					axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAGTTGGGGGGACACAAGCA	0.612000													4	23					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056223	9056223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9056223C>T	ENST00000397910.4	-	3	31426	c.31223G>A	c.(31222-31224)gGa>gAa	p.G10408E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10410	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCACTGTTCCCAGCTCAAC	0.478000													65	182					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173416	126173416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:126173416G>A	ENST00000339582.2	-	9	2828	c.2020C>T	c.(2020-2022)Cac>Tac	p.H674Y	GRM8_ENST00000444921.2_Missense_Mutation_p.H674Y|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Missense_Mutation_p.H674Y			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	674					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AATATTCGGTGGATACGGTTT	0.502000										HNSCC(24;0.065)			23	87					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47278192	47278192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47278192G>A	ENST00000271153.4	+	4	428	c.392G>A	c.(391-393)gGg>gAg	p.G131E	CYP4B1_ENST00000371923.4_Missense_Mutation_p.G131E|CYP4B1_ENST00000371919.4_Missense_Mutation_p.G116E|CYP4B1_ENST00000452782.2_5'UTR			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	131					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.G131V(1)		NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					GTTCTTGAGGGGCCCAAGTGG	0.587000													11	25					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70924276	70924276	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70924276G>A	ENST00000603540.1	+	2	318	c.60G>A	c.(58-60)ggG>ggA	p.G20G	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Silent_p.G20G	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	20					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TCTGGCTTGGGGTATTTTTGT	0.537000													47	106					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008550	120008550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:120008550C>T	ENST00000341846.5	-	1	611	c.190G>A	c.(190-192)Gaa>Aaa	p.E64K		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	64					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CTCCTACCTTCCCCTGGCTTC	0.632000													53	156					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579921	140579921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140579921C>T	ENST00000354757.3	+	1	574	c.574C>T	c.(574-576)Ccc>Tcc	p.P192S	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		192	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGGAAATACCCCGAGTTAGT	0.463000													16	66					0	0	1	0	0
SLC8B1	80024	broad.mit.edu	37	12	113759020	113759020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113759020G>A	ENST00000552014.1	-	4	805	c.290C>T	c.(289-291)cCt>cTt	p.P97L	SLC24A6_ENST00000546737.1_Missense_Mutation_p.P97L|SLC24A6_ENST00000202831.3_Missense_Mutation_p.P97L|SLC24A6_ENST00000553238.1_5'UTR			Q6J4K2	NCKX6_HUMAN		97					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						GACAGCCAGAGGGAGGAGGCT	0.642000													18	114					0	0	1	0	0
KLK12	43849	broad.mit.edu	37	19	51534092	51534092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51534092C>T	ENST00000529888.1	-	4	358	c.283G>A	c.(283-285)Gag>Aag	p.E95K	KLK12_ENST00000525263.1_Silent_p.T181T|CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000319590.4_Silent_p.T181T|KLK12_ENST00000250351.4_Silent_p.T181T|KLK12_ENST00000250352.11_Silent_p.T71T	NM_145895.1	NP_665902.1	Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	0	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		CCATGTTGCTCGTGATTCTCC	0.617000													59	123					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231216	21231216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21231216C>T	ENST00000233242.1	-	26	8651	c.8524G>A	c.(8524-8526)Gaa>Aaa	p.E2842K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2842					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACAGCATTTCACTCCCATGC	0.418000													23	216					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11504574	11504574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:11504574G>A	ENST00000379237.1	-	15	2747	c.2353C>T	c.(2353-2355)Ccc>Tcc	p.P785S	USP6NL_ENST00000277575.5_Missense_Mutation_p.P802S	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	785						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						TATCTCACGGGACTATCTACA	0.532000													56	165					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101583015	101583015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:101583015G>A	ENST00000310954.6	-	10	2038	c.1752C>T	c.(1750-1752)ttC>ttT	p.F584F		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	584					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TTACAATAAAGAAAATGCAAA	0.358000													54	86					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14498703	14498703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14498703C>T	ENST00000344204.4	+	53	8310	c.8286C>T	c.(8284-8286)gtC>gtT	p.V2762V	TRIO_ENST00000537187.1_Silent_p.V2586V|TRIO_ENST00000344135.5_Silent_p.V261V	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2762	Ig-like C2-type.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GCATCGCTGTCAATGACATGG	0.587000													42	87					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703603	4703603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4703603G>A	ENST00000396950.3	-	2	578	c.339C>T	c.(337-339)atC>atT	p.I113I		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGCCAGCAGGATGGTGGATT	0.517000													15	45					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3729195	3729195	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3729195G>T	ENST00000315677.3	-	7	2126	c.1531C>A	c.(1531-1533)Ctg>Atg	p.L511M	DLGAP1_ENST00000400149.3_Missense_Mutation_p.L219M|DLGAP1_ENST00000581699.1_Missense_Mutation_p.L217M|DLGAP1_ENST00000400150.3_Missense_Mutation_p.L217M|DLGAP1_ENST00000400145.2_Missense_Mutation_p.L209M|DLGAP1_ENST00000581527.1_Missense_Mutation_p.L511M|DLGAP1_ENST00000539435.1_Missense_Mutation_p.L209M|DLGAP1_ENST00000478161.1_5'UTR|DLGAP1_ENST00000400155.1_Missense_Mutation_p.L217M|DLGAP1_ENST00000400147.2_Missense_Mutation_p.L209M|DLGAP1_ENST00000534970.1_Missense_Mutation_p.L223M|DLGAP1_ENST00000515196.2_Missense_Mutation_p.L511M|DLGAP1_ENST00000584874.1_Missense_Mutation_p.L511M	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	511					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GACGACCTCAGGGACACGCAC	0.687000													6	41					0.0215528	0.0215557	1	1	0
NID1	4811	broad.mit.edu	37	1	236212147	236212147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236212147C>T	ENST00000264187.6	-	2	450	c.368G>A	c.(367-369)cGa>cAa	p.R123Q	NID1_ENST00000366595.3_Missense_Mutation_p.R123Q	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	123	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TAAGTCTTCTCGATAATAAAC	0.567000													22	66					0	0	1	0	0
SMARCC1	6599	broad.mit.edu	37	3	47703861	47703861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47703861G>A	ENST00000254480.5	-	20	2240	c.2121C>T	c.(2119-2121)gaC>gaT	p.D707D	SMARCC1_ENST00000425518.1_5'UTR	NM_003074.3	NP_003065.3	Q92922	SMRC1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	707					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		CCACGCGAGGGTCCACCACAG	0.478000													17	59					0	0	1	0	0
ATP1B4	23439	broad.mit.edu	37	X	119500593	119500593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:119500593C>T	ENST00000218008.3	+	2	334	c.277C>T	c.(277-279)Ctg>Ttg	p.L93L	ATP1B4_ENST00000361319.3_Silent_p.L93L|ATP1B4_ENST00000539306.1_Silent_p.L93L	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	93					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						GAGTGAATACCTGTGGGATCC	0.502000													20	13					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155757560	155757560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155757560C>T	ENST00000159060.2	-	7	892	c.790G>A	c.(790-792)Gaa>Aaa	p.E264K		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	264	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		ACCGAGGGTTCCTTGCCAGAA	0.438000													32	62					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41423891	41423891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41423891C>T	ENST00000400454.1	-	30	5656	c.5179G>A	c.(5179-5181)Gga>Aga	p.G1727R		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1727					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCACTCGTTCCCGGCCGAGCG	0.478000													32	178					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144994645	144994645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144994645G>A	ENST00000322810.4	-	32	9924	c.9755C>T	c.(9754-9756)tCc>tTc	p.S3252F	PLEC_ENST00000356346.3_Missense_Mutation_p.S3101F|PLEC_ENST00000357649.2_Missense_Mutation_p.S3119F|PLEC_ENST00000436759.2_Missense_Mutation_p.S3142F|PLEC_ENST00000527096.1_Missense_Mutation_p.S3138F|PLEC_ENST00000398774.2_Missense_Mutation_p.S3083F|PLEC_ENST00000345136.3_Missense_Mutation_p.S3115F|PLEC_ENST00000354589.3_Missense_Mutation_p.S3115F|PLEC_ENST00000354958.2_Missense_Mutation_p.S3093F	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3252	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CTGGAACAGGGAGACGCTCTG	0.657000													5	21					0	0	1	0	0
PARP9	83666	broad.mit.edu	37	3	122247235	122247235	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122247235G>A	ENST00000360356.2	-	11	2768	c.2541C>T	c.(2539-2541)ttC>ttT	p.F847F	PARP9_ENST00000471785.1_Silent_p.F812F|PARP9_ENST00000492382.1_Silent_p.F392F|PARP9_ENST00000477522.2_Silent_p.F812F	NM_001146102.1|NM_031458.2	NP_001139574.1|NP_113646.2	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	847	PARP catalytic.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		TGCCACTTGCGAATCCCCTCC	0.448000													46	106					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100623364	100623364	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:100623364G>A	ENST00000317233.4	-	6	838	c.603C>T	c.(601-603)gcC>gcT	p.A201A	AFF3_ENST00000356421.2_Silent_p.A226A|AFF3_ENST00000409236.1_Silent_p.A201A|AFF3_ENST00000409579.1_Silent_p.A226A	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	201					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGGCCGCCATGGCAGGTGGCC	0.587000													37	85					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72509755	72509755	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72509755G>A	ENST00000319622.6	-	3	697	c.241C>T	c.(241-243)Cat>Tat	p.H81Y	PKM_ENST00000389093.3_Missense_Mutation_p.H81Y|PKM_ENST00000568883.1_Intron|PKM_ENST00000568459.1_Missense_Mutation_p.H81Y|PKM_ENST00000335181.5_Missense_Mutation_p.H81Y|PKM_ENST00000565154.1_Missense_Mutation_p.H81Y|PKM_ENST00000565184.1_Missense_Mutation_p.H81Y|PKM_ENST00000449901.2_Intron	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						CTCACCTCATGAGTTCCATGA	0.507000													34	76					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47976806	47976806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47976806C>T	ENST00000543600.1	-	2	459	c.420G>A	c.(418-420)gtG>gtA	p.V140V	PTCHD4_ENST00000339488.4_Silent_p.V157V			Q6ZW05	CF138_HUMAN	patched domain containing 4	157						integral to membrane	hedgehog receptor activity										TTGGCACTTCCACTACCCCGC	0.478000													11	27					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130883776	130883776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:130883776G>A	ENST00000509018.1	-	6	664	c.459C>T	c.(457-459)acC>acT	p.T153T	RAPGEF6_ENST00000308008.6_Silent_p.T153T|RAPGEF6_ENST00000507093.1_Silent_p.T153T|RAPGEF6_ENST00000510071.1_Silent_p.T153T|RAPGEF6_ENST00000296859.6_Silent_p.T153T|FNIP1_ENST00000514667.1_Silent_p.T203T|RAPGEF6_ENST00000307984.5_Silent_p.T153T	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	153					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CATCAGTAATGGTTTGGCGCT	0.333000													33	107					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179449180	179449180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179449180C>T	ENST00000589042.1	-	311	65322	c.65098G>A	c.(65098-65100)Gaa>Aaa	p.E21700K	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E19132K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E20059K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E12827K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E12760K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E12635K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20059							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTTTCTTTCCTTGCGTTCA	0.443000													28	65					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169783678	169783678	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169783678C>G	ENST00000263817.6	-	26	3730	c.3606G>C	c.(3604-3606)atG>atC	p.M1202I		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1202	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTGGGAGTGACATGACAAAAT	0.453000													18	181					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96180974	96180974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:96180974C>T	ENST00000343702.4	-	2	776	c.328G>A	c.(328-330)Gag>Aag	p.E110K	NTN4_ENST00000344911.4_Missense_Mutation_p.E73K|NTN4_ENST00000553059.1_Missense_Mutation_p.E110K|NTN4_ENST00000538383.1_Missense_Mutation_p.E73K	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	110	Laminin N-terminal.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						TGCACATCCTCCGCAGACTGC	0.532000													18	46					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33840377	33840377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33840377C>T	ENST00000389232.4	+	9	857	c.787C>T	c.(787-789)Ctt>Ttt	p.L263F	RYR3_ENST00000415757.3_Missense_Mutation_p.L263F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	263	MIR 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGCCAGGTCTCTTTGGAGAGT	0.493000													10	16					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179561820	179561820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179561820G>A	ENST00000444136.1	+	2	320	c.70G>A	c.(70-72)Gat>Aat	p.D24N	TDRD5_ENST00000367614.1_Missense_Mutation_p.D24N|TDRD5_ENST00000294848.8_Missense_Mutation_p.D24N	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	24	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						TTCCACCAAAGATGGTTTGAG	0.483000													16	146					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141116507	141116507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:141116507G>A	ENST00000389484.3	-	73	12111	c.11140C>T	c.(11140-11142)Ctt>Ttt	p.L3714F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3714	LDL-receptor class A 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.L3714I(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GATGGACAAAGAAATTTGACT	0.368000										TSP Lung(27;0.18)			35	84					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185229469	185229469	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:185229469G>A	ENST00000296252.4	-	9	1252	c.1111C>T	c.(1111-1113)Cag>Tag	p.Q371*	LIPH_ENST00000424591.2_Nonsense_Mutation_p.Q337*	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	371					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TGATATTTCTGAAATGTGGTG	0.393000													28	80					0	0	1	0	0
AREG	374	broad.mit.edu	37	4	75312457	75312457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:75312457G>A	ENST00000395748.3	+	2	480	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K	AREG_ENST00000502307.1_Missense_Mutation_p.E90K|AREG_ENST00000264487.2_Missense_Mutation_p.E90K	NM_001657.2	NP_001648.1	P15514	AREG_HUMAN	amphiregulin	90					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity			lung(4)	4			Lung(101;0.196)			GTATGATAACGAACCACAAAT	0.448000													35	80					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106431439	106431439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:106431439C>T	ENST00000407775.2	+	2	358	c.108C>T	c.(106-108)tcC>tcT	p.S36S	ZFPM2_ENST00000520492.1_5'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	36					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ACATCATCTCCAAAGGAGACT	0.408000													12	58					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62954404	62954404	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:62954404C>T	ENST00000393630.3	+	27	3937	c.3546C>T	c.(3544-3546)gaC>gaT	p.D1182D	MON2_ENST00000393632.2_Silent_p.D1181D|MON2_ENST00000552738.1_Silent_p.D1158D|MON2_ENST00000280379.6_Silent_p.D1182D|MON2_ENST00000393629.2_Silent_p.D1181D|MON2_ENST00000546600.1_Silent_p.D1181D	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	1182					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CTGTCAGAGACTCAGATAAGC	0.448000													33	57					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66436970	66436970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66436970C>T	ENST00000341529.3	+	12	2401	c.2253C>T	c.(2251-2253)tcC>tcT	p.S751S	CDH5_ENST00000539168.1_Silent_p.S190S	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	751	Ser-rich.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CCGACTCATCCGACTCTGACG	0.622000													9	26					0	0	1	0	0
C1orf216	127703	broad.mit.edu	37	1	36181917	36181917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36181917G>A	ENST00000270815.4	-	2	776	c.6C>T	c.(4-6)ttC>ttT	p.F2F	C1orf216_ENST00000503824.1_5'UTR	NM_152374.1	NP_689587.1	Q8TAB5	CA216_HUMAN	chromosome 1 open reading frame 216	2										kidney(2)|lung(3)|skin(2)|urinary_tract(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GCTGGATGGCGAACATCTAGC	0.582000											OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	19					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3212029	3212029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3212029G>A	ENST00000380059.3	-	8	1125	c.1024C>T	c.(1024-1026)Ccg>Tcg	p.P342S	SLC4A11_ENST00000380056.3_Missense_Mutation_p.P315S|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Missense_Mutation_p.P299S	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	315					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						TTCGTTCTCGGCGCCACTGGA	0.662000													25	53					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68160436	68160436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68160436C>T	ENST00000349223.5	+	3	1548	c.1324C>T	c.(1324-1326)Cat>Tat	p.H442Y	NFATC3_ENST00000575270.1_Missense_Mutation_p.H442Y|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000329524.4_Missense_Mutation_p.H442Y|NFATC3_ENST00000346183.3_Missense_Mutation_p.H442Y	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	442	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		ACCTAAAACTCATCATCGAGC	0.438000													35	60					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50283263	50283263	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50283263C>T	ENST00000320634.3	-	9	746		c.e9+1		FAIM2_ENST00000550890.1_Splice_Site	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2						anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						CCAGAGCTGACCTTGGTCTGG	0.657000													4	57					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91744422	91744422	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91744422G>A	ENST00000389857.6	-	29	4988	c.4902C>T	c.(4900-4902)ccC>ccT	p.P1634P	CCDC88C_ENST00000331194.7_Silent_p.P158P	NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1634					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TCCGAGGCAAGGGGTACTCGT	0.701000													7	12					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17317979	17317979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17317979C>T	ENST00000595618.1	+	35	5702	c.5550C>T	c.(5548-5550)ttC>ttT	p.F1850F	MYO9B_ENST00000397274.2_Silent_p.F1850F|MYO9B_ENST00000594824.1_Silent_p.F1850F|CTD-3032J10.3_ENST00000601929.1_RNA	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1850	Rho-GAP.|Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						CCATTATCTTCGCACCCTGCC	0.647000													5	4					0	0	1	0	0
PANX3	116337	broad.mit.edu	37	11	124489364	124489364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124489364G>A	ENST00000284288.2	+	4	779	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3	238					protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CTTCTTCCAGGAAGAATTCAG	0.498000													15	36					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56232592	56232592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56232592C>T	ENST00000268912.5	+	1	99	c.78C>T	c.(76-78)ttC>ttT	p.F26F		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TCCAGAAATTCCTGTTCCTTC	0.478000													66	162					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40412184	40412184	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40412184G>A	ENST00000221347.6	-	7	3451	c.3444C>T	c.(3442-3444)ggC>ggT	p.G1148G		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1148	Cys-rich.|TIL 2.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACAGCGGGCAGCCGTAGGAAC	0.612000													16	55					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4872438	4872438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4872438G>A	ENST00000252318.2	+	8	1716	c.1379G>A	c.(1378-1380)gGa>gAa	p.G460E		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	460						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						ATAGATTTTGGAGACGTTTCT	0.398000													12	79					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54574665	54574665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54574665C>T	ENST00000336470.4	+	9	773	c.634C>T	c.(634-636)Cgt>Tgt	p.R212C	GNL3L_ENST00000360845.2_Missense_Mutation_p.R212C	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	212					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						TTTCCAGAATCGTTGCAGTGT	0.478000													9	5					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83218215	83218215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83218215G>A	ENST00000563800.1	-	9	3200	c.1475C>T	c.(1474-1476)cCc>cTc	p.P492L	CPEB1_ENST00000398592.2_Missense_Mutation_p.P239L|CPEB1_ENST00000261723.6_Missense_Mutation_p.P468L|RP11-152F13.10_ENST00000562833.1_Missense_Mutation_p.P200S|CPEB1_ENST00000568757.1_Missense_Mutation_p.P390L|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000562019.1_Missense_Mutation_p.P470L|CPEB1_ENST00000398591.2_Missense_Mutation_p.P395L|CPEB1_ENST00000568128.1_Missense_Mutation_p.P465L|CPEB1_ENST00000450751.2_Missense_Mutation_p.P390L|CPEB1_ENST00000423133.2_Missense_Mutation_p.P390L|CPEB1_ENST00000564522.1_Missense_Mutation_p.P390L			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	470	Necessary for stress granule assembly and correct localization in dcp1 bodies.|RRM 2.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			CTTACCAATGGGATACTTGTG	0.522000													17	56					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891650	5891650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:5891650C>T	ENST00000581347.1	-	3	1058	c.413G>A	c.(412-414)cGa>cAa	p.R138Q	TMEM200C_ENST00000383490.2_Missense_Mutation_p.R138Q|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	138						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						GGAGGCGGCTCGTGCTGGAGG	0.652000													12	50					0	0	1	0	0
ENTPD2	954	broad.mit.edu	37	9	139944958	139944958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139944958G>A	ENST00000355097.2	-	6	854	c.807C>T	c.(805-807)ggC>ggT	p.G269G	ENTPD2_ENST00000312665.5_Silent_p.G269G	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	269						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGGTGGAAAAGCCCCTCGGCC	0.642000											OREG0019627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	22					0	0	1	0	0
POTED	317754	broad.mit.edu	37	21	15013746	15013746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:15013746G>A	ENST00000299443.5	+	11	1666	c.1614G>A	c.(1612-1614)ctG>ctA	p.L538L		NM_174981.3|NM_207355.2	NP_778146.2|NP_997238.2	Q86YR6	POTED_HUMAN	POTE ankyrin domain family, member D	538						plasma membrane				central_nervous_system(1)|large_intestine(10)|liver(2)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	33						TGCTAAGACTGGAACTAGATG	0.363000													25	26					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57481086	57481086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57481086G>A	ENST00000371236.2	-	12	1177	c.914C>T	c.(913-915)gCt>gTt	p.A305V	DAB1_ENST00000420954.2_Missense_Mutation_p.A303V|DAB1_ENST00000439789.2_Missense_Mutation_p.A219V|DAB1_ENST00000371234.4_Missense_Mutation_p.A305V|DAB1_ENST00000371231.1_Missense_Mutation_p.A338V|DAB1_ENST00000414851.2_Missense_Mutation_p.A287V|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	338					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CGGGAGGACAGCGCCCATTGC	0.582000													14	25					0	0	1	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333369	28333369	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:28333369C>T	ENST00000377255.3	+	7	1221	c.924C>T	c.(922-924)gcC>gcT	p.A308A	ZKSCAN3_ENST00000341464.5_Silent_p.A160A|ZKSCAN3_ENST00000252211.2_Silent_p.A308A	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	308					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						AGAAAAATGCCACAGGAGGGA	0.502000													20	53					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53418996	53418996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:53418996C>T	ENST00000377942.3	-	3	3115	c.2912G>A	c.(2911-2913)gGg>gAg	p.G971E	PCDH8_ENST00000338862.4_Missense_Mutation_p.G874E	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	971					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding	p.G971V(1)		breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TGCGTTGGGCCCGCTGCAGGA	0.582000													10	39					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103352543	103352543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103352543C>T	ENST00000358392.2	-	63	5031	c.4714G>A	c.(4714-4716)Ggc>Agc	p.G1572S	COL11A1_ENST00000512756.1_Missense_Mutation_p.G1444S|COL11A1_ENST00000353414.4_Missense_Mutation_p.G1521S|COL11A1_ENST00000370096.3_Missense_Mutation_p.G1560S	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1560					collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.G1560C(1)|p.G1572C(1)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTTGCATGCCTTCAGTATGT	0.393000													48	127					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88284438	88284438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:88284438G>A	ENST00000357081.3	-	8	768	c.624C>T	c.(622-624)atC>atT	p.I208I	AGTPBP1_ENST00000376081.4_Silent_p.I208I|AGTPBP1_ENST00000432218.1_Silent_p.I46I|AGTPBP1_ENST00000491784.1_5'UTR|AGTPBP1_ENST00000337006.4_Silent_p.I150I|AGTPBP1_ENST00000376080.1_Silent_p.I150I|AGTPBP1_ENST00000376083.3_Silent_p.I208I|AGTPBP1_ENST00000376109.3_Silent_p.I260I			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	208					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						ATGGTCCAATGATTTTAAACA	0.348000													8	90					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114641717	114641717	+	Splice_Site	SNP	G	G	A	rs149899868		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114641717G>A	ENST00000393296.1	-	5	1440	c.1364_splice	c.e5+1	p.R455_splice	SYT6_ENST00000369547.1_Splice_Site_p.R370_splice			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	455	C2 2.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCTACCTACCGATCATAGTCC	0.512000													45	92					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156749	22156749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22156749G>A	ENST00000397126.4	-	4	1235	c.1087C>T	c.(1087-1089)Cat>Tat	p.H363Y	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTCCAGTATGAATTACCTTA	0.388000													22	48					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107858195	107858195	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107858195G>A	ENST00000328300.6	+	30	2694	c.2450G>A	c.(2449-2451)gGa>gAa	p.G817E	COL4A5_ENST00000361603.2_Missense_Mutation_p.G817E	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	817	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGGCTGCCAGGAATAGGTGTT	0.438000									Alport syndrome with Diffuse Leiomyomatosis				24	14					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27939826	27939826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27939826C>T	ENST00000374005.3	-	12	1573	c.1285G>A	c.(1285-1287)Gct>Act	p.A429T	FGR_ENST00000399173.1_Missense_Mutation_p.A429T|FGR_ENST00000374004.1_Missense_Mutation_p.A429T|FGR_ENST00000545953.1_Missense_Mutation_p.A363T	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	429	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AAGAGGGCAGCTTCTGGGGCT	0.547000													12	120					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1459935	1459935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1459935G>A	ENST00000345913.4	+	7	791	c.700G>A	c.(700-702)Gga>Aga	p.G234R	TPO_ENST00000497517.2_Intron|TPO_ENST00000349624.3_Missense_Mutation_p.G234R|TPO_ENST00000382198.1_Missense_Mutation_p.G234R|TPO_ENST00000337415.3_Missense_Mutation_p.G234R|TPO_ENST00000382201.3_Missense_Mutation_p.G234R|TPO_ENST00000329066.4_Missense_Mutation_p.G234R|TPO_ENST00000346956.3_Missense_Mutation_p.G234R	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	234					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GATGGCATGGGGACAATACAT	0.522000													11	28					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933552	44933552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44933552C>T	ENST00000291187.4	-	6	1708	c.1386G>A	c.(1384-1386)aaG>aaA	p.K462K	ZNF229_ENST00000588931.1_Silent_p.K468K|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				AGCTGAATCCCTTTCCACACT	0.552000													19	58					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815650	158815650	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158815650G>A	ENST00000368141.4	+	5	1105	c.844G>A	c.(844-846)Gaa>Aaa	p.E282K		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	282	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					GGAAATAAAGGAAGCATCATC	0.338000													24	72					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733510	152733510	+	Silent	SNP	G	G	A	rs138516775		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152733510G>A	ENST00000368773.1	+	2	1504	c.1446G>A	c.(1444-1446)ccG>ccA	p.P482P	KPRP_ENST00000606109.1_Silent_p.P482P	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	482	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCCCTGCCGGCGCCCTGCC	0.657000													41	95					0	0	1	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55610167	55610167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55610167G>A	ENST00000263433.3	-	6	951	c.936C>T	c.(934-936)gcC>gcT	p.A312A	PPP1R12C_ENST00000435544.2_Silent_p.A238A|PPP1R12C_ENST00000376393.2_Silent_p.A312A	NM_001271618.1|NM_017607.2	NP_001258547.1|NP_060077.1	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	312						cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	22			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CCTGTTTCCGGGCCAGTTCCT	0.637000													19	51					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47384223	47384223	+	Missense_Mutation	SNP	C	C	T	rs71737295		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47384223C>T	ENST00000232766.5	+	9	1261	c.1241C>T	c.(1240-1242)aCc>aTc	p.T414I	KLHL18_ENST00000455924.2_Missense_Mutation_p.T302I	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	414										endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		ACAGTGGTGACCTCGATGAGC	0.507000													18	48					0	0	1	0	0
LZTS3	9762	broad.mit.edu	37	20	3147736	3147736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3147736G>A	ENST00000329152.3	-	1	1471	c.74C>T	c.(73-75)cCc>cTc	p.P25L	LZTS3_ENST00000360342.3_Missense_Mutation_p.P25L|LZTS3_ENST00000337576.5_Missense_Mutation_p.P25L	NM_014731.2	NP_055546.1																					AAGCTCGGAGGGCCGTGGGGC	0.701000													3	2					0	0	1	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16734107	16734107	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:16734107C>T	ENST00000297967.5	+	1	207	c.108C>T	c.(106-108)ttC>ttT	p.F36F	NLGN4Y_ENST00000476359.1_3'UTR	NM_001164238.1	NP_001157710.1	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked	36					brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity			large_intestine(3)|lung(7)|prostate(2)|skin(2)	14						CCATCAAGTTCACCCTCATTG	0.468000													30	31					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70933777	70933777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:70933777G>A	ENST00000334414.6	-	24	5664	c.5620C>T	c.(5620-5622)Cgt>Tgt	p.R1874C	PTPRB_ENST00000550358.1_Missense_Mutation_p.R1786C|PTPRB_ENST00000261266.5_Missense_Mutation_p.R1656C|PTPRB_ENST00000451516.2_Missense_Mutation_p.R1566C|PTPRB_ENST00000538708.1_Missense_Mutation_p.R1566C|PTPRB_ENST00000550857.1_Missense_Mutation_p.R1566C	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1656	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATGCTCAGACGGGCAGAGGGT	0.418000													10	31					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065757	35065757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35065757C>T	ENST00000382002.5	-	10	1729	c.1303G>A	c.(1303-1305)Gat>Aat	p.D435N	PRLR_ENST00000511486.1_Missense_Mutation_p.D334N|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.D334N|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	435					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TCACACACATCAGTAATATTG	0.483000													27	173					0	0	1	0	0
CLCN4	1183	broad.mit.edu	37	X	10176240	10176240	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:10176240C>T	ENST00000380833.4	+	9	1390	c.999C>T	c.(997-999)ttC>ttT	p.F333F	CLCN4_ENST00000421085.2_Silent_p.F239F|CLCN4_ENST00000380829.1_Intron	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	333						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CTGAACTCTTCCCCTTCATCC	0.572000													65	54					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58067416	58067416	+	Silent	SNP	C	C	T	rs80356507		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58067416C>T	ENST00000357272.4	+	4	865	c.700C>T	c.(700-702)Ctg>Ttg	p.L234L	FLNB_ENST00000493452.1_Silent_p.L65L|FLNB_ENST00000490882.1_Silent_p.L234L|FLNB_ENST00000429972.2_Silent_p.L234L|FLNB_ENST00000419752.2_Silent_p.L65L|FLNB_ENST00000348383.5_Silent_p.L234L|FLNB_ENST00000295956.4_Silent_p.L234L|FLNB_ENST00000358537.3_Silent_p.L234L			O75369	FLNB_HUMAN	filamin B, beta	234	Actin-binding.|CH 2.		L -> V (in LRS1).		actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TATGACTTACCTGTCCCAGTT	0.527000													12	136					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800898	21800898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21800898C>T	ENST00000443632.2	+	2	2086	c.1714C>T	c.(1714-1716)Cgt>Tgt	p.R572C	HIC2_ENST00000407598.2_Missense_Mutation_p.R572C|HIC2_ENST00000407464.2_Missense_Mutation_p.R572C			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	572					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GCGCTTCACCCGTCAGTACCG	0.627000													13	56					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22364016	22364016	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22364016G>A	ENST00000397121.2	-	3	820	c.503C>T	c.(502-504)tCc>tTc	p.S168F		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ACATTTGTAGGAATTCTCTCT	0.338000													37	82					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13107074	13107074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:13107074C>T	ENST00000319217.7	-	47	6350	c.6103G>A	c.(6103-6105)Gat>Aat	p.D2035N	MPDZ_ENST00000381015.4_Missense_Mutation_p.D2035N|MPDZ_ENST00000538841.1_Missense_Mutation_p.D894N|MPDZ_ENST00000447879.1_Missense_Mutation_p.D2002N|MPDZ_ENST00000381022.2_Missense_Mutation_p.D2006N|MPDZ_ENST00000541718.1_Missense_Mutation_p.D2006N|MPDZ_ENST00000541093.1_Missense_Mutation_p.D269N|MPDZ_ENST00000536827.1_Missense_Mutation_p.D1973N|MPDZ_ENST00000546205.1_Missense_Mutation_p.D2049N	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	2035	PDZ 13.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		ATGATCTGATCGCCCCTTTTC	0.448000													22	138					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3670728	3670728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3670728G>A	ENST00000344754.4	-	18	4774	c.4775C>T	c.(4774-4776)tCc>tTc	p.S1592F	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.S1592F	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1592	Ig-like C2-type 16.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGCATTGGGGGAAGCCAGGAC	0.632000													5	15					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16199342	16199342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16199342C>T	ENST00000375759.3	+	2	319	c.115C>T	c.(115-117)Ccc>Tcc	p.P39S		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	39	RRM 1.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CAAAATTCTTCCCAAGAGGGG	0.398000													27	65					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070073	9070073	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9070073C>T	ENST00000397910.4	-	3	17576	c.17373G>A	c.(17371-17373)gaG>gaA	p.E5791E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5793	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTTGATCTCCTCAGACGTCC	0.458000													25	50					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836648	142836648	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142836648G>A	ENST00000291009.3	+	4	394	c.354G>A	c.(352-354)cgG>cgA	p.R118R		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	118						extracellular region	actin binding	p.R118R(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		ATGTTATTCGGGAATTAGGCA	0.453000													66	141					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25255686	25255686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25255686G>A	ENST00000400358.4	+	9	862	c.805G>A	c.(805-807)Gac>Aac	p.D269N	SGSM1_ENST00000400359.4_Missense_Mutation_p.D269N	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	269						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TCTGCAGAGGGACGACATGGA	0.557000													27	42					0	0	1	0	0
DCTN3	11258	broad.mit.edu	37	9	34614060	34614060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34614060G>A	ENST00000259632.7	-	6	465	c.450C>T	c.(448-450)ctC>ctT	p.L150L	DCTN3_ENST00000477738.2_Intron|DCTN3_ENST00000447983.2_3'UTR|DCTN3_ENST00000378916.4_Silent_p.L122L|DCTN3_ENST00000341694.2_3'UTR|DCTN3_ENST00000479399.1_5'UTR	NM_007234.3	NP_009165.1	O75935	DCTN3_HUMAN	dynactin 3 (p22)	150					cytokinesis|G2/M transition of mitotic cell cycle|mitosis	centrosome|cleavage furrow|condensed chromosome kinetochore|cytosol|dynactin complex|midbody|perinuclear region of cytoplasm|spindle	protein binding|structural molecule activity			large_intestine(1)|skin(1)	2	all_epithelial(49;0.0863)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.0388)		ATTCCTCCAGGAGAGCCTTGG	0.498000													36	70					0	0	1	0	0
MS4A6E	245802	broad.mit.edu	37	11	60105331	60105331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60105331G>A	ENST00000300182.4	+	2	330	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K		NM_139249.2	NP_640342.1	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member 6E	89						integral to membrane	receptor activity	p.E89K(1)		endometrium(2)|kidney(1)|lung(9)|stomach(1)	13						TAAGTTGGACGAAAAGGATAT	0.453000													53	102					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94898020	94898020	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94898020G>A	ENST00000289495.5	+	11	2973		c.e11+1		PPP1R9A_ENST00000424654.1_Splice_Site|PPP1R9A_ENST00000433360.1_Splice_Site|PPP1R9A_ENST00000340694.4_Splice_Site|PPP1R9A_ENST00000456331.2_Splice_Site|PPP1R9A_ENST00000433881.1_Splice_Site	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A							cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGAGAGAAAGGTGAGCACCCT	0.443000										HNSCC(28;0.073)			15	50					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127379290	127379290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127379290C>T	ENST00000342480.6	+	3	458	c.419C>T	c.(418-420)cCa>cTa	p.P140L		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	140					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						CAAGAGCTGCCAAACCTCCCC	0.498000													14	64					0	0	1	0	0
BASP1	10409	broad.mit.edu	37	5	17275909	17275909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:17275909C>T	ENST00000322611.3	+	2	844	c.584C>T	c.(583-585)tCc>tTc	p.S195F		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	195					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						GCGCCTAGTTCCACACCCAAG	0.642000													5	40					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60558971	60558971	+	Missense_Mutation	SNP	G	G	A	rs141490536	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:60558971G>A	ENST00000373886.3	+	12	1688	c.1684G>A	c.(1684-1686)Gaa>Aaa	p.E562K	BICC1_ENST00000263103.1_Missense_Mutation_p.E188K	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	562					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						TATGCAGACCGAAGGCAAAAA	0.468000													7	23					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78789991	78789991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78789991C>T	ENST00000545128.1	+	14	2384	c.1846C>T	c.(1846-1848)Cgc>Tgc	p.R616C	PCSK5_ENST00000376767.3_Missense_Mutation_p.R616C|PCSK5_ENST00000376752.4_Missense_Mutation_p.R616C	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	616					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GGAACGGTTCCGCTATAGCCG	0.488000													35	83					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206305266	206305266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206305266C>T	ENST00000406610.2	+	20	3121	c.2914C>T	c.(2914-2916)Cca>Tca	p.P972S	PARD3B_ENST00000351153.1_Missense_Mutation_p.P903S|PARD3B_ENST00000349953.3_Intron|PARD3B_ENST00000358768.2_Missense_Mutation_p.P910S	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	972					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CTTTAGATCTCCATCTCCCCC	0.483000													60	97					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203681213	203681213	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:203681213C>T	ENST00000357681.5	+	13	3280	c.2157C>T	c.(2155-2157)ttC>ttT	p.F719F	ATP2B4_ENST00000391954.2_Silent_p.F719F|ATP2B4_ENST00000367219.3_Silent_p.F707F|ATP2B4_ENST00000341360.2_Silent_p.F719F|ATP2B4_ENST00000367218.3_Silent_p.F719F	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	719					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GGGATGACTTCCTGTGCTTAG	0.532000													27	91					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61949998	61949998	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61949998G>A	ENST00000336844.5	-	4	546	c.395C>T	c.(394-396)tCg>tTg	p.S132L	CSH2_ENST00000392886.2_Missense_Mutation_p.S132L|CSH2_ENST00000345366.7_Intron|CSH2_ENST00000560142.1_Missense_Mutation_p.S75L	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	132					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						ATCGCTGTCCGAGGTGTCATA	0.597000													29	64					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70281924	70281924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:70281924C>T	ENST00000377844.4	-	10	2779	c.2020G>A	c.(2020-2022)Gat>Aat	p.D674N	KLHL1_ENST00000545028.1_Missense_Mutation_p.D481N	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	674					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GTTTTGGGATCATATCTAAAA	0.368000													13	51					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129180	6129180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6129180G>A	ENST00000316529.3	+	1	267	c.172G>A	c.(172-174)Gag>Aag	p.E58K		NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATTCAACATGAGACCGTGCT	0.522000													23	44					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56243414	56243414	+	Missense_Mutation	SNP	G	G	A	rs143466064		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56243414G>A	ENST00000332836.2	-	2	1810	c.1783C>T	c.(1783-1785)Cgc>Tgc	p.R595C		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	595						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ACACACATGCGAAGTGTCGTT	0.393000													15	63					0	0	1	0	0
NR0B1	190	broad.mit.edu	37	X	30327363	30327363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:30327363C>T	ENST00000378970.4	-	1	352	c.118G>A	c.(118-120)Ggc>Agc	p.G40S	NR0B1_ENST00000453287.1_Missense_Mutation_p.G40S	NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	40	4 X 67 AA tandem repeats.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	CACGAACAGCCCCAGCACTGA	0.657000													4	7					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560363	44560363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44560363C>T	ENST00000332567.4	-	1	1625	c.1273G>A	c.(1273-1275)Gat>Aat	p.D425N	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	425					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTAGCCGAATCCCAGGACTCA	0.547000													41	98					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126226912	126226912	+	Silent	SNP	C	C	T	rs139167502	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126226912C>T	ENST00000290868.2	-	5	491	c.438G>A	c.(436-438)tcG>tcA	p.S146S	UROC1_ENST00000383579.3_Silent_p.S146S	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	146					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CTGTCATCTTCGACAAGTAGA	0.587000													21	134					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126091028	126091028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:126091028G>A	ENST00000318410.7	-	6	1012	c.663C>T	c.(661-663)ttC>ttT	p.F221F	KIAA0196_ENST00000517845.1_Silent_p.F73F	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	221					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CCATACTGATGAAGGATTCGT	0.413000													29	80					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2542543	2542543	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2542543C>T	ENST00000358864.1	+	4	456	c.441C>T	c.(439-441)tcC>tcT	p.S147S		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	147	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						GTGGGGAGTCCCTGTCCGAGG	0.612000													24	65					0	0	1	0	0
RTP1	132112	broad.mit.edu	37	3	186917640	186917640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186917640G>A	ENST00000312295.4	+	2	604	c.574G>A	c.(574-576)Gag>Aag	p.E192K	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	192					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		AGAGTTCTGCGAGGCCTGCCA	0.701000													12	32					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179526210	179526210	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:179526210C>T	ENST00000467460.1	-	13	1698	c.1368G>A	c.(1366-1368)ggG>ggA	p.G456G	PEX5L_ENST00000472994.1_Silent_p.G397G|PEX5L_ENST00000468741.1_Silent_p.G264G|PEX5L_ENST00000465751.1_Silent_p.G432G|PEX5L_ENST00000464614.1_Silent_p.G348G|PEX5L_ENST00000392649.3_Silent_p.G348G|PEX5L_ENST00000263962.8_Silent_p.G454G|PEX5L_ENST00000485199.1_Silent_p.G421G|PEX5L_ENST00000476138.1_Silent_p.G413G|PEX5L_ENST00000467440.2_5'UTR	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	456					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			ATTCCTTCACCCCTTCCAGAA	0.398000													33	81					0	0	1	0	0
MYLK2	85366	broad.mit.edu	37	20	30418653	30418653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30418653G>A	ENST00000375994.2	+	8	1529	c.1256G>A	c.(1255-1257)gGg>gAg	p.G419E	MYLK2_ENST00000375985.4_Missense_Mutation_p.G419E|MYLK2_ENST00000468730.1_3'UTR			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	419	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AACACCACCGGGCATTTGGTG	0.627000													83	215					0	0	1	0	0
RCBTB1	55213	broad.mit.edu	37	13	50115837	50115837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:50115837G>A	ENST00000378302.2	-	11	1559	c.1299C>T	c.(1297-1299)gtC>gtT	p.V433V	RCBTB1_ENST00000258646.3_Silent_p.V433V	NM_018191.3	NP_060661.3	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	433	BTB 1.				cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|urinary_tract(1)	16		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		GCGGCAGGTCGACTGTGTCTG	0.458000													30	50					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61894123	61894123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61894123G>A	ENST00000280772.1	-	25	2938	c.2747C>T	c.(2746-2748)tCc>tTc	p.S916F	ANK3_ENST00000355288.2_Missense_Mutation_p.S50F|ANK3_ENST00000503366.1_Missense_Mutation_p.S917F|ANK3_ENST00000373827.2_Missense_Mutation_p.S910F	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	916					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CGAACTGAAGGAGCGGAGGCT	0.418000													12	28					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55823374	55823374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55823374C>T	ENST00000309383.1	+	19	2552	c.2275C>T	c.(2275-2277)Ccc>Tcc	p.P759S	BRSK1_ENST00000326848.7_Missense_Mutation_p.P454S|BRSK1_ENST00000590333.1_Missense_Mutation_p.P775S	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	759					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GAGCAGCTCTCCCCGCCGAGG	0.741000													5	7					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14747289	14747289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:14747289G>A	ENST00000380881.4	-	34	6800	c.5985C>T	c.(5983-5985)tcC>tcT	p.S1995S	FREM1_ENST00000380894.1_Silent_p.S530S|FREM1_ENST00000380880.3_Silent_p.S1994S|FREM1_ENST00000422223.2_Silent_p.S1994S			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1994					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGTCAGTTGTGGATTCCACCT	0.423000													40	131					0	0	1	0	0
IGKV1D-17	28900	broad.mit.edu	37	2	90121694	90121694	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:90121694C>T	ENST00000483379.1	+	0	218																											CCTGGGGCTCCTGCTGCTCTG	0.507000													25	140					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117278829	117278829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:117278829C>T	ENST00000355044.3	+	25	3837	c.3711C>T	c.(3709-3711)ttC>ttT	p.F1237F	ATRNL1_ENST00000303745.7_Silent_p.F30F|ATRNL1_ENST00000423111.2_Silent_p.F288F	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1237						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTGTCACCTTCTTCAGGTAAA	0.323000													9	36					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160113175	160113175	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:160113175G>A	ENST00000327245.5	-	6	1227	c.381C>T	c.(379-381)ttC>ttT	p.F127F	CTC-529G1.1_ENST00000524198.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	127					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATGATGACGAACAGGACAA	0.423000													16	35					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670531	49670531	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:49670531C>T	ENST00000561648.1	-	4	2585	c.2532G>A	c.(2530-2532)ggG>ggA	p.G844G	ZNF423_ENST00000562871.1_Silent_p.G784G|ZNF423_ENST00000535559.1_Silent_p.G727G|ZNF423_ENST00000567169.1_Silent_p.G727G|ZNF423_ENST00000562520.1_Silent_p.G784G|ZNF423_ENST00000563137.2_Silent_p.G784G|ZNF423_ENST00000262383.2_Silent_p.G844G	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	844					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TTGGGGGTACCCCATTGGCCG	0.597000													10	27					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34549924	34549924	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34549924G>A	ENST00000354181.3	-	6	1101	c.609C>T	c.(607-609)atC>atT	p.I203I	RP11-1084A12.2_ENST00000559867.1_RNA|SLC12A6_ENST00000560611.1_Silent_p.I203I|SLC12A6_ENST00000558589.1_Silent_p.I194I|SLC12A6_ENST00000558667.1_Silent_p.I203I|SLC12A6_ENST00000451844.2_Intron|SLC12A6_ENST00000458406.2_Silent_p.I144I|SLC12A6_ENST00000560164.1_Intron|SLC12A6_ENST00000290209.5_Silent_p.I152I|SLC12A6_ENST00000397707.2_Silent_p.I188I|SLC12A6_ENST00000397702.2_Silent_p.I144I			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	203					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GTAAAAAAAGGATCACTCCAA	0.443000													8	28					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27151149	27151149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27151149G>A	ENST00000288699.6	+	5	785	c.627G>A	c.(625-627)ggG>ggA	p.G209G	DPYSL5_ENST00000401478.1_Silent_p.G209G	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	209					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGATTTGGGGATCACAGGCC	0.478000													11	36					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157803146	157803146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157803146G>A	ENST00000368174.4	-	5	971	c.875C>T	c.(874-876)tCt>tTt	p.S292F		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	292	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GAAGGAGGGAGAGAGGGACTT	0.587000													15	125					0	0	1	0	0
NPBWR1	2831	broad.mit.edu	37	8	53852583	53852583	+	Missense_Mutation	SNP	C	C	T	rs145057890		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:53852583C>T	ENST00000331251.3	+	1	1593	c.116C>T	c.(115-117)gCt>gTt	p.A39V		NM_005285.3	NP_005276.2	P48145	NPBW1_HUMAN	neuropeptides B/W receptor 1	39					synaptic transmission	plasma membrane	opioid receptor activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)	17		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				CTGGCGGTGGCTGTACCAGTT	0.716000													11	22					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138633391	138633391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:138633391G>A	ENST00000218099.2	+	6	698	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K	F9_ENST00000394090.2_Missense_Mutation_p.E193K	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	231	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGTTGGTGGAGAAGATGCCAA	0.453000													41	23					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107019899	107019899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:107019899C>T	ENST00000369063.3	-	9	1628	c.1163G>A	c.(1162-1164)cGa>cAa	p.R388Q	RTN4IP1_ENST00000498091.1_5'UTR|RTN4IP1_ENST00000539449.1_3'UTR	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	388						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		AGTCTTTCCTCGTGCGTGTCC	0.383000													22	34					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48684206	48684206	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48684206G>A	ENST00000544264.1	-	22	7580	c.7300C>T	c.(7300-7302)Cga>Tga	p.R2434*	CELSR3_ENST00000164024.4_Nonsense_Mutation_p.R2429*			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2429					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTGGCACCTCGGCGTTCTGCC	0.592000													8	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179489358	179489358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179489358C>T	ENST00000589042.1	-	242	44873	c.44649G>A	c.(44647-44649)gtG>gtA	p.V14883V	TTN_ENST00000342992.6_Silent_p.V12315V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.V13242V|TTN_ENST00000342175.6_Silent_p.V6010V|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.V5943V|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V5818V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13242	Fibronectin type-III 7.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAACCATTTCACCTTAGCAT	0.458000													24	58					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6650760	6650760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6650760G>A	ENST00000299441.3	-	12	5495	c.5084C>T	c.(5083-5085)tCt>tTt	p.S1695F		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1695	Cadherin 16.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGATCCAGAGAAAAGCTTTC	0.547000													6	16					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71152304	71152304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71152304C>T	ENST00000355527.3	-	6	871	c.595G>A	c.(595-597)Ggc>Agc	p.G199S	DHCR7_ENST00000407721.2_Missense_Mutation_p.G199S	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	199					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	AAGAAGTAGCCCTTGACCATG	0.567000									Smith-Lemli-Opitz syndrome				21	63					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40599853	40599853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40599853G>A	ENST00000260402.3	-	1	270	c.21C>T	c.(19-21)gtC>gtT	p.V7V	PLCB2_ENST00000543785.2_Silent_p.V7V|PLCB2_ENST00000456256.2_Silent_p.V7V|PLCB2_ENST00000557821.1_Silent_p.V7V	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	7					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GGGGCAGCAGGACAGGGTTGA	0.607000													11	52					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13663341	13663341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13663341G>A	ENST00000404922.3	+	9	2341	c.2222G>A	c.(2221-2223)gGa>gAa	p.G741E	FBLN2_ENST00000535798.1_Intron|FBLN2_ENST00000492059.1_Missense_Mutation_p.G741E|FBLN2_ENST00000295760.7_Intron	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	741	EGF-like 3; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AACACCCTGGGATCCTTCTAC	0.587000													17	42					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43756497	43756497	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:43756497C>T	ENST00000458276.2	+	5	843	c.720C>T	c.(718-720)ttC>ttT	p.F240F		NM_016006.4	NP_057090.2	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	240					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			kidney(3)|large_intestine(2)|liver(2)|lung(5)|ovary(1)|skin(1)	14		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		CTTCAATGTTCGAAGACGATA	0.368000													17	192					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101295475	101295475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101295475G>A	ENST00000538618.1	+	4	410	c.410G>A	c.(409-411)cGg>cAg	p.R137Q	ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000392977.3_5'UTR|ANO4_ENST00000299222.9_5'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						ATCCATCAACGGCGAAGTGTG	0.502000										HNSCC(74;0.22)			9	60					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110763690	110763690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:110763690G>A	ENST00000451085.1	+	4	1908	c.862G>A	c.(862-864)Gag>Aag	p.E288K	IMMP2L_ENST00000489381.1_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.E288K|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000331762.3_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.E288K|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000447215.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	288						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ACACTTAAAAGAGTTGGGGAT	0.333000													38	85					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124311371	124311371	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124311371G>A	ENST00000409039.3	+	24	3988	c.3963G>A	c.(3961-3963)ttG>ttA	p.L1321L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1321	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CCTACTACTTGGAAGCAAAAA	0.453000													40	60					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220479908	220479908	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220479908C>T	ENST00000456909.1	+	24	3052	c.2962C>T	c.(2962-2964)Cct>Tct	p.P988S	STK11IP_ENST00000295641.10_Missense_Mutation_p.P999S			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	999					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGAGCCCTCTCCTCCAGCAGC	0.657000													8	16					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43322566	43322566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43322566G>A	ENST00000361428.2	-	4	2583	c.2506C>T	c.(2506-2508)Cgt>Tgt	p.R836C	ZNF318_ENST00000318149.3_Missense_Mutation_p.R836C	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	836					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GGGATCACACGAAGATTGGGA	0.527000													11	101					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017356	93017356	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:93017356C>T	ENST00000523629.1	-	6	1182	c.728G>A	c.(727-729)cGa>cAa	p.R243Q	RUNX1T1_ENST00000521553.1_Missense_Mutation_p.R206Q|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.R206Q|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.R206Q|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.R254Q|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.R216Q|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.R206Q|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.R243Q|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.R216Q	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	243					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R206Q(1)|p.R254Q(1)|p.R243L(1)|p.R243Q(1)|p.R254L(1)|p.R206L(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GTCTGGAGTTCGCCTCTTCCC	0.522000													21	113					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197596851	197596851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197596851C>T	ENST00000389175.4	+	27	3299	c.3164C>T	c.(3163-3165)tCt>tTt	p.S1055F	CCDC150_ENST00000409270.1_Missense_Mutation_p.S542F|CCDC150_ENST00000272831.7_Missense_Mutation_p.S702F	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	1055										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CAGAGGCCTTCTGGGGAAGAC	0.423000													22	73					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171247961	171247961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171247961G>A	ENST00000354841.4	+	4	709	c.578G>A	c.(577-579)gGa>gAa	p.G193E	FMO1_ENST00000402921.2_Missense_Mutation_p.G130E|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.G193E			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	193					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTGGAATGGGAAATTCTGGC	0.433000													12	54					0	0	1	0	0
KCTD4	386618	broad.mit.edu	37	13	45768148	45768148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:45768148C>T	ENST00000405872.1	-	2	958	c.555G>A	c.(553-555)gaG>gaA	p.E185E	KCTD4_ENST00000379108.1_Silent_p.E185E|GTF2F2_ENST00000340473.6_Intron	NM_198404.2	NP_940686.2	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerization domain containing 4	185						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		TTGAAAACTCCTCTGGAAATC	0.363000													51	107					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133748382	133748382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133748382C>T	ENST00000318560.5	+	6	1424	c.1043C>T	c.(1042-1044)tCg>tTg	p.S348L		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	348	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	ACTCAGATCTCGTCAGCCATG	0.607000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								7	52					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47043884	47043884	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47043884C>T	ENST00000450053.3	+	32	5354	c.5175C>T	c.(5173-5175)ttC>ttT	p.F1725F	NBEAL2_ENST00000383740.2_Silent_p.F4F|NBEAL2_ENST00000292309.5_Silent_p.F1541F	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1725							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TGTCCCAGTTCGAAATGGACA	0.582000													23	60					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197184344	197184344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:197184344C>T	ENST00000260983.2	-	9	1452	c.1270G>A	c.(1270-1272)Gaa>Aaa	p.E424K	HECW2_ENST00000409111.1_Missense_Mutation_p.E68K	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	424					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CCATTGTGTTCGATAGCATCT	0.512000													22	45					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156957	22156957	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22156957G>A	ENST00000397126.4	-	4	1027	c.879C>T	c.(877-879)gcC>gcT	p.A293A	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCTTACTAAAGGCTTTGCCAC	0.393000													24	64					0	0	1	0	0
MIR654	724024	broad.mit.edu	37	14	101506599	101506599	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:101506599C>T	ENST00000385199.1	+	0	44					NR_030390.1																						GTGCTGAGTTCGTGCCATATG	0.577000													5	12					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204944446	204944446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204944446G>A	ENST00000367172.4	+	15	1934	c.1606G>A	c.(1606-1608)Ggc>Agc	p.G536S	NFASC_ENST00000513543.1_Missense_Mutation_p.G547S|NFASC_ENST00000338586.6_Missense_Mutation_p.G536S|NFASC_ENST00000367169.4_Missense_Mutation_p.G536S|NFASC_ENST00000360049.4_Missense_Mutation_p.G547S|NFASC_ENST00000367171.4_Missense_Mutation_p.G536S|NFASC_ENST00000401399.1_Missense_Mutation_p.G536S|NFASC_ENST00000539706.1_Missense_Mutation_p.G547S|NFASC_ENST00000403080.1_Missense_Mutation_p.G536S|NFASC_ENST00000367170.4_Missense_Mutation_p.G536S|NFASC_ENST00000339876.6_Missense_Mutation_p.G536S|NFASC_ENST00000404907.1_Missense_Mutation_p.G547S|NFASC_ENST00000404076.1_Missense_Mutation_p.G530S|NFASC_ENST00000338515.6_Missense_Mutation_p.G536S			O94856	NFASC_HUMAN	neurofascin	536	Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGCCAGAAGGGGCACCACGGT	0.622000											OREG0014142	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	48	102					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956201	18956201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18956201C>T	ENST00000302797.3	-	1	355	c.131G>A	c.(130-132)gGa>gAa	p.G44E	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	44					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AACTGCGTTTCCTGTCAGCCC	0.567000													67	160					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178392033	178392033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178392033C>T	ENST00000320129.3	+	5	931	c.628C>T	c.(628-630)Cat>Tat	p.H210Y	ZNF454_ENST00000519564.1_Missense_Mutation_p.H210Y	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		TCAGAAAATTCATATTAAGGA	0.358000													14	51					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144945144	144945144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144945144G>A	ENST00000525985.1	-	2	2349	c.2278C>T	c.(2278-2280)Cct>Tct	p.P760S				P58107	EPIPL_HUMAN	epiplakin 1	760						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCGTCAGAAGGGTCCAACAGG	0.642000													40	125					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27528443	27528443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27528443G>A	ENST00000301904.3	+	6	1416	c.1396G>A	c.(1396-1398)Gga>Aga	p.G466R	SCARA3_ENST00000337221.4_Intron	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	466	Collagen-like 1.				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		AGGACCAAGAGGATTCAAAGG	0.662000													31	133					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158589991	158589991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158589991C>T	ENST00000368148.3	-	44	6566	c.6386G>A	c.(6385-6387)aGg>aAg	p.R2129K	SPTA1_ENST00000368147.3_Missense_Mutation_p.R2126K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2129					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTTCCAGGTCCTTTCCAGCAC	0.448000													20	103					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286690	152286690	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152286690A>G	ENST00000368799.1	-	3	707	c.672T>C	c.(670-672)acT>acC	p.T224T	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	224					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCATTTTTGAGTCATTCTTC	0.348000									Ichthyosis				26	92					0	0	1	0	0
HS3ST6	64711	broad.mit.edu	37	16	1962130	1962130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1962130G>A	ENST00000454677.2	-	2	606	c.541C>T	c.(541-543)Ccc>Tcc	p.P181S	HS3ST6_ENST00000443547.1_Missense_Mutation_p.P133S|HS3ST6_ENST00000293937.3_Missense_Mutation_p.P164S			C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	133										endometrium(2)|lung(2)	4						ATGCGGCGGGGGGCCTCTCGC	0.662000													9	9					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48713043	48713043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:48713043G>A	ENST00000236495.5	+	15	1999	c.1949G>A	c.(1948-1950)tGg>tAg	p.W650*	SLC5A9_ENST00000471020.1_3'UTR|SLC5A9_ENST00000438567.2_Nonsense_Mutation_p.W625*|SLC5A9_ENST00000533824.1_Nonsense_Mutation_p.W646*	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	625						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						CTCTGGAGCTGGTTCTGTGGG	0.577000													14	29					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53040680	53040680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53040680G>A	ENST00000309680.3	-	7	1334	c.1313C>T	c.(1312-1314)gCc>gTc	p.A438V		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	438	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CTTGTTCCTGGCATCCTTGAG	0.567000													45	96					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38886150	38886150	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38886150G>A	ENST00000274276.3	+	7	1251	c.849G>A	c.(847-849)ggG>ggA	p.G283G	OSMR_ENST00000502536.1_Silent_p.G283G	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	283					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					GATTTTCTGGGGAAAAGAAAC	0.333000													22	43					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467317	74467317	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74467317G>A	ENST00000249842.3	+	2	475	c.118G>A	c.(118-120)Gac>Aac	p.D40N	ISLR_ENST00000395118.1_Missense_Mutation_p.D40N|RP11-665J16.1_ENST00000561647.1_RNA	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	40	LRRNT.				cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						TGCCTACCGCGACCTAGAATC	0.652000													29	102					0	0	1	0	0
CYBB	1536	broad.mit.edu	37	X	37663303	37663303	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:37663303C>T	ENST00000378588.4	+	9	1138	c.1071C>T	c.(1069-1071)atC>atT	p.I357I	TM4SF2_ENST00000465127.1_Intron|CYBB_ENST00000545017.1_Silent_p.I325I|CYBB_ENST00000492288.1_3'UTR|CYBB_ENST00000536160.1_Silent_p.I90I	NM_000397.3	NP_000388.2	P04839	CY24B_HUMAN	cytochrome b-245, beta polypeptide	357	FAD-binding FR-type.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|prostate(2)|skin(2)	32						ATATCCGCATCGTTGGGGACT	0.468000													12	56					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	432479	432479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:432479G>A	ENST00000256509.2	+	21	3208	c.2566G>A	c.(2566-2568)Gga>Aga	p.G856R	CHL1_ENST00000397491.2_Missense_Mutation_p.G840R	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	840	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAGAGTACATGGACGTCTGAA	0.383000													9	70					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44433089	44433089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44433089G>A	ENST00000372343.3	+	19	3378	c.2716G>A	c.(2716-2718)Gag>Aag	p.E906K	IPO13_ENST00000372339.3_Missense_Mutation_p.E124K	NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	906					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GTGGATCAAGGAGGCCCTGCA	0.617000													36	70					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11059584	11059584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11059584C>T	ENST00000287766.4	+	4	715	c.294C>T	c.(292-294)ttC>ttT	p.F98F	SLC6A1_ENST00000536032.1_Intron|SLC6A1-AS1_ENST00000414969.2_RNA	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	98					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCCCACTCTTCCTGCTGGAGT	0.567000													43	106					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858321	9858321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9858321G>A	ENST00000396573.2	-	14	3389	c.3080C>T	c.(3079-3081)tCc>tTc	p.S1027F	GRIN2A_ENST00000535259.1_Missense_Mutation_p.S870F|GRIN2A_ENST00000404927.2_Missense_Mutation_p.S1027F|GRIN2A_ENST00000562109.1_Missense_Mutation_p.S1027F|GRIN2A_ENST00000330684.3_Missense_Mutation_p.S1027F|GRIN2A_ENST00000396575.2_Missense_Mutation_p.S1027F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1027					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGATTCTGGGATAGTGAATC	0.542000													18	123					0	0	1	0	0
PLIN1	5346	broad.mit.edu	37	15	90214766	90214766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90214766C>T	ENST00000300055.5	-	4	445	c.280G>A	c.(280-282)Ggc>Agc	p.G94S	PLIN1_ENST00000430628.2_Missense_Mutation_p.G94S	NM_002666.4	NP_002657.3	O60240	PLIN1_HUMAN	perilipin 1	94					triglyceride catabolic process	lipid particle	lipid binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(2)	13						TGGTCCAAGCCTCGGCAGGCC	0.612000													7	2					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106970943	106970943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106970943C>T	ENST00000369701.3	+	17	2537	c.2310C>T	c.(2308-2310)ttC>ttT	p.F770F	SORCS3_ENST00000369699.4_Silent_p.F56F	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	770						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCCCAGCTTTCTGGTACAATC	0.448000													23	47					0	0	1	0	0
TREM2	54209	broad.mit.edu	37	6	41126689	41126689	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:41126689C>T	ENST00000373122.4	-	4	658	c.638G>A	c.(637-639)tGg>tAg	p.W213*	TREM2_ENST00000373113.3_Missense_Mutation_p.G200R|TREM2_ENST00000338469.3_Intron			Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	0					axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	11	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGCTTCTGTCCATGCCAGGCT	0.582000													21	56					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65789011	65789011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65789011C>T	ENST00000312106.5	-	4	1784	c.1647G>A	c.(1645-1647)aaG>aaA	p.K549K		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	549					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CCCGCAGGCTCTTGAAGACCT	0.612000													7	28					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55216155	55216155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:55216155G>A	ENST00000340465.2	+	5	561	c.475G>A	c.(475-477)Gga>Aga	p.G159R		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	159						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTCAGCAAATGGAAATCCGTG	0.458000													74	212					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49691586	49691586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49691586G>A	ENST00000296452.4	+	5	4711	c.4597G>A	c.(4597-4599)Ggt>Agt	p.G1533S		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1533					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGTAGCCCAGGGTACACAAAC	0.612000													39	92					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278912	36278912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36278912C>T	ENST00000007510.4	+	21	3589	c.3445C>T	c.(3445-3447)Cac>Tac	p.H1149Y	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.H985Y|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.H988Y			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1149					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						TCCCCCTGACCACCTTGGCTA	0.667000													6	71					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54919601	54919601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54919601C>T	ENST00000474759.1	+	23	2092	c.2044C>T	c.(2044-2046)Cct>Tct	p.P682S	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.P588S|CACNA2D3-AS1_ENST00000471265.1_RNA|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.P682S|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.P682S	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	682						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AGGCAAAGAACCTCTGCTCCA	0.468000													6	9					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44118029	44118029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:44118029C>T	ENST00000259746.9	+	17	1772	c.1589C>T	c.(1588-1590)cCc>cTc	p.P530L	TMEM63B_ENST00000323267.6_Missense_Mutation_p.P530L			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	530						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTGCTCCTACCCTCGCTGGGA	0.592000													32	68					0	0	1	0	0
GTPBP4	23560	broad.mit.edu	37	10	1038576	1038576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:1038576C>T	ENST00000360803.4	+	2	278	c.196C>T	c.(196-198)Cta>Tta	p.L66L	GTPBP4_ENST00000545048.1_Silent_p.L19L|GTPBP4_ENST00000491635.1_3'UTR|GTPBP4_ENST00000538293.1_5'UTR	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	66					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TTCACAAATTCTAACAGATTT	0.348000													11	29					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519328	113519328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113519328C>T	ENST00000284601.3	-	4	1887	c.1819G>A	c.(1819-1821)Ggc>Agc	p.G607S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	607					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AAAGCGCTGCCTTCACTAGTC	0.423000													56	165					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34123547	34123547	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34123547G>A	ENST00000373381.4	-	27	4622	c.4447_splice	c.e27+1	p.I1482_splice	CSMD2_ENST00000373380.1_Splice_Site_p.I355_splice|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1442	CUB 9.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCTTTGTACCGATGCATGTTG	0.587000													27	83					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135766	156135766	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156135766G>A	ENST00000329476.3	+	2	1164	c.675G>A	c.(673-675)ttG>ttA	p.L225L	NPY2R_ENST00000506608.1_Silent_p.L225L	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	225					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CTTCCTTGTTGATCTTGTATG	0.443000													29	114					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112705119	112705119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112705119G>A	ENST00000448454.2	+	8	656	c.656G>A	c.(655-657)gGa>gAa	p.G219E	PALM2_ENST00000374531.2_Missense_Mutation_p.G185E|PALM2-AKAP2_ENST00000302798.7_Intron|PALM2-AKAP2_ENST00000374530.3_Intron|AKAP2_ENST00000555236.1_Intron|AKAP2_ENST00000510514.5_Intron|PALM2_ENST00000314527.4_Missense_Mutation_p.G217E|PALM2_ENST00000483909.1_Missense_Mutation_p.G183E					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						GTGCGCTCAGGAGGCACCGTA	0.468000													4	44					0	0	1	0	0
NIPAL1	152519	broad.mit.edu	37	4	48036926	48036926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:48036926G>A	ENST00000295461.5	+	5	556	c.490G>A	c.(490-492)Gag>Aag	p.E164K	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	164						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						CTTTTTAAACGAGCACTTGAA	0.378000													36	68					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730546	96730546	+	Missense_Mutation	SNP	G	G	A	rs145002930		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96730546G>A	ENST00000216629.6	+	3	1133	c.527G>A	c.(526-528)cGa>cAa	p.R176Q	BDKRB1_ENST00000553356.1_Missense_Mutation_p.R176Q|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	176					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TTCCTGCTGCGATCCATCCAA	0.612000													36	84					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12247800	12247800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12247800C>T	ENST00000256194.4	+	14	2059	c.1771C>T	c.(1771-1773)Cct>Tct	p.P591S	MICAL2_ENST00000379612.3_Missense_Mutation_p.P591S|MICAL2_ENST00000342902.5_Missense_Mutation_p.P591S|MICAL2_ENST00000527546.1_Missense_Mutation_p.P591S|MICAL2_ENST00000537344.1_Missense_Mutation_p.P591S	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	591	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		GTTTGGGATCCCTCCAGTGAC	0.512000													40	93					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106163486	106163486	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106163486G>A	ENST00000369704.3	+	14	2173		c.e14-1			NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147											NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GTCTTATTCAGACAGGAGTTT	0.403000													4	23					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10250079	10250079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10250079G>A	ENST00000418404.3	-	12	1344	c.1181C>T	c.(1180-1182)tCt>tTt	p.S394F	MYH13_ENST00000570743.1_Missense_Mutation_p.S394F|MYH13_ENST00000252172.4_Missense_Mutation_p.S394F			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	394	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CATTTCTGCAGAATTCAGTCC	0.473000													16	21					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158911994	158911994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158911994C>T	ENST00000368140.1	+	5	1052	c.807C>T	c.(805-807)atC>atT	p.I269I	PYHIN1_ENST00000485134.1_3'UTR|PYHIN1_ENST00000392254.2_Silent_p.I269I|PYHIN1_ENST00000368138.3_Silent_p.I260I|PYHIN1_ENST00000392252.3_Silent_p.I260I	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	269	HIN-200.				cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					AGAGAATCATCATTATATCAA	0.378000													15	52					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15580433	15580433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15580433G>A	ENST00000292609.4	-	4	1780	c.1651C>T	c.(1651-1653)Cgc>Tgc	p.R551C	PGLYRP2_ENST00000340880.4_Intron			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	0					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						TGCAGGCTGCGAAGACTCACC	0.716000													13	2					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119025267	119025267	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:119025267G>A	ENST00000307417.3	+	5	886	c.522G>A	c.(520-522)caG>caA	p.Q174Q	ABCG4_ENST00000531739.1_Silent_p.Q174Q|ABCG4_ENST00000449422.2_Silent_p.Q174Q	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	174	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GTGAGAAGCAGGAGGTGAAGA	0.582000													9	26					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40337484	40337484	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:40337484G>A	ENST00000310169.2	+	0	139					NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)						elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	TCAGGAAAAAGATGAACTGGT	0.498000													14	41					0	0	1	0	0
MAGEH1	28986	broad.mit.edu	37	X	55479462	55479462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:55479462C>T	ENST00000342972.1	+	1	925	c.655C>T	c.(655-657)Cct>Tct	p.P219S		NM_014061.3	NP_054780.2	Q9H213	MAGH1_HUMAN	melanoma antigen family H, 1	219					apoptosis			p.P219S(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|skin(2)	15						TTATTCCGCCCCTTAAGTAGA	0.493000													24	17					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114289975	114289975	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114289975C>T	ENST00000309235.5	+	2	458	c.300C>T	c.(298-300)ttC>ttT	p.F100F	ZNF483_ENST00000374374.3_Silent_p.F100F|ZNF483_ENST00000355824.3_Silent_p.F100F|ZNF483_ENST00000358151.4_Silent_p.F100F	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	100	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						TTGAGCAGTTCCTGACCATTT	0.473000													33	75					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142446126	142446126	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142446126C>A	ENST00000606664.1	+	0	1482				MROH5_ENST00000430863.1_RNA																							GCCACCAGGTCCCCGAACAGT	0.677000													7	35					0.000157383	0.000157605	1	1	0
ANKRD20A4	728747	broad.mit.edu	37	9	69420413	69420413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:69420413G>A	ENST00000357336.3	+	13	1584	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K		NM_001098805.1	NP_001092275.1	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	435										breast(1)|large_intestine(1)|liver(1)|lung(9)|pancreas(2)|skin(2)	16						GAAGCTGAAGGAAGAGCATGA	0.358000													11	192					0	0	1	0	0
LEKR1	389170	broad.mit.edu	37	3	156711062	156711062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:156711062G>A	ENST00000470811.1	+	10	1528	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	LEKR1_ENST00000356539.4_Missense_Mutation_p.E369K			D3DNK7	D3DNK7_HUMAN	leucine, glutamate and lysine rich 1	74										breast(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	11			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			ACTGAAAAATGAAAGGTGCAG	0.294000													19	68					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95174054	95174054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:95174054C>T	ENST00000354268.4	+	9	1250	c.1177C>T	c.(1177-1179)Ctt>Ttt	p.L393F	SMARCAD1_ENST00000457823.2_Missense_Mutation_p.L393F			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	393					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TCTTCACTTCCTTCAAGATGC	0.408000													16	114					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82785568	82785568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82785568G>A	ENST00000423517.2	-	2	726	c.389C>T	c.(388-390)cCt>cTt	p.P130L	PCLO_ENST00000333891.8_Missense_Mutation_p.P130L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	130					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AATAGTGGAAGGACTCCTCCC	0.478000													27	82					0	0	1	0	0
PLXDC1	57125	broad.mit.edu	37	17	37224179	37224179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37224179G>A	ENST00000315392.4	-	14	1628	c.1417C>T	c.(1417-1419)Cgc>Tgc	p.R473C	PLXDC1_ENST00000539608.1_3'UTR|PLXDC1_ENST00000493200.1_5'UTR|PLXDC1_ENST00000444911.2_Missense_Mutation_p.R433C|CTD-2206N4.4_ENST00000583447.1_RNA	NM_020405.4	NP_065138.2	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1	473					angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						GGGTGGCTGCGAAACTTCATG	0.617000													21	40					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688082	55688082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55688082C>T	ENST00000358433.2	-	1	934	c.935G>A	c.(934-936)aGa>aAa	p.R312K		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TTAAAATGGTCTTTTAGAAAA	0.388000													15	24					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168199802	168199802	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168199802C>T	ENST00000519560.1	-	14	1862	c.1443G>A	c.(1441-1443)aaG>aaA	p.K481K	SLIT3_ENST00000332966.8_Silent_p.K481K|SLIT3_ENST00000404867.3_Silent_p.K481K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	481	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCGGAACTTCTTGCTCTTGA	0.607000													15	46					0	0	1	0	0
LACRT	90070	broad.mit.edu	37	12	55025539	55025539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55025539C>T	ENST00000257867.4	-	4	391	c.338G>A	c.(337-339)gGa>gAa	p.G113E	LACRT_ENST00000547511.1_Missense_Mutation_p.G102E	NM_033277.1	NP_150593.1	Q9GZZ8	LACRT_HUMAN	lacritin	113					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(1)	10						GAATTGTTTTCCACCTGGCAC	0.473000													57	147					0	0	1	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153314127	153314127	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153314127G>A	ENST00000368739.3	-	6	947	c.589C>T	c.(589-591)Cgg>Tgg	p.R197W	PGLYRP4_ENST00000359650.5_Missense_Mutation_p.R201W			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	201					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTTCTGCCGAGGGGCCAGG	0.542000													39	114					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145894431	145894431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145894431C>T	ENST00000311104.2	-	1	1322	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K		NM_194251.2	NP_919227.2	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	416						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTAACACCTTCCCCTGTCTCT	0.403000													6	16					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10933857	10933857	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10933857C>T	ENST00000298232.7	-	16	1335	c.968G>A	c.(967-969)gGc>gAc	p.G323D	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.G303D|TPTE_ENST00000361285.4_Missense_Mutation_p.G341D	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	341	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTACCTGTGCCTCCTTTACA	0.328000													23	281					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17361191	17361191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17361191C>T	ENST00000252597.3	-	13	2128	c.1955G>A	c.(1954-1956)cGg>cAg	p.R652Q	AC010646.3_ENST00000594059.1_Intron|USHBP1_ENST00000431146.2_Missense_Mutation_p.R588Q	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	652							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						TTCCTGCTTCCGGTGGGCTCC	0.667000													23	46					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10435015	10435015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10435015C>T	ENST00000245503.5	-	22	3016	c.2632G>A	c.(2632-2634)Gaa>Aaa	p.E878K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E878K|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	878					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCTTCCAGTTCCTTCCTTTTT	0.423000													38	41					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173189	126173189	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:126173189G>A	ENST00000339582.2	-	9	3055	c.2247C>T	c.(2245-2247)ctC>ctT	p.L749L	GRM8_ENST00000444921.2_Silent_p.L749L|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Silent_p.L749L			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	749					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GTGAACAAATGAGTGAGAGAT	0.463000										HNSCC(24;0.065)			9	41					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8051146	8051146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:8051146C>T	ENST00000344293.5	+	5	2627	c.2421C>T	c.(2419-2421)ctC>ctT	p.L807L		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	807	Pro-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						gccccatgctcgtcagccctg	0.806000													5	7					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80374441	80374441	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:80374441G>A	ENST00000265361.3	-	18	2586	c.2025C>T	c.(2023-2025)tcC>tcT	p.S675S	SEMA3C_ENST00000544525.1_Silent_p.S693S|SEMA3C_ENST00000419255.2_Silent_p.S675S	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	675					immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						AGGTCCATGGGGACCATTTGT	0.463000													36	75					0	0	1	0	0
ARHGEF25	115557	broad.mit.edu	37	12	58006880	58006880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:58006880C>T	ENST00000286494.4	+	2	725	c.265C>T	c.(265-267)Ctc>Ttc	p.L89F	AC025165.8_ENST00000444467.1_RNA|AC025165.8_ENST00000356672.3_RNA|ARHGEF25_ENST00000333972.7_Missense_Mutation_p.L128F	NM_182947.3	NP_891992.2	Q86VW2	ARHGP_HUMAN	Rho guanine nucleotide exchange factor (GEF) 25	89					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	28						CAAACATTGTCTCAGTGTGGA	0.592000													4	33					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6733289	6733289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6733289G>A	ENST00000264080.7	-	9	773	c.747C>T	c.(745-747)ccC>ccT	p.P249P	GPR108_ENST00000430424.4_Silent_p.P7P	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	249						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						GGAAGCCATCGGGGTTCTTCT	0.657000													19	38					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49710967	49710967	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:49710967G>A	ENST00000451037.2	-	8	1774	c.834C>T	c.(832-834)atC>atT	p.I278I	CA10_ENST00000442502.2_Silent_p.I278I|CA10_ENST00000340813.6_Silent_p.I284I|CA10_ENST00000570565.1_Silent_p.I203I|CA10_ENST00000285273.4_Silent_p.I278I	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	278					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGCTCAGAAAGATCTGAGATG	0.512000													21	67					0	0	1	0	0
MGST2	4258	broad.mit.edu	37	4	140616381	140616381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:140616381C>T	ENST00000265498.1	+	3	441	c.189C>T	c.(187-189)ttC>ttT	p.F63F	MGST2_ENST00000515137.1_3'UTR|MGST2_ENST00000506797.1_Intron	NM_001204366.1|NM_002413.4	NP_001191295.1|NP_002404.1	Q99735	MGST2_HUMAN	microsomal glutathione S-transferase 2	63					glutathione biosynthetic process|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane|plasma membrane	enzyme activator activity|glutathione peroxidase activity|glutathione transferase activity|leukotriene-C4 synthase activity			lung(1)|ovary(1)	2	all_hematologic(180;0.162)				Glutathione(DB00143)	ATCCTATATTCATAATTACAT	0.318000													12	64					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278595	50278595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:50278595G>A	ENST00000442544.2	+	2	879	c.263G>A	c.(262-264)aGg>aAg	p.R88K	DCC_ENST00000412726.1_5'UTR	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	88	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ATGGATGAAAGGAAGCAGCAA	0.483000													20	99					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9047337	9047337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:9047337G>A	ENST00000457346.2	-	21	2840	c.2766C>T	c.(2764-2766)acC>acT	p.T922T	SCUBE2_ENST00000520467.1_Silent_p.T865T|SCUBE2_ENST00000450649.2_Silent_p.T701T|SCUBE2_ENST00000309263.3_Silent_p.T893T|RP11-467K18.2_ENST00000531592.1_RNA			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	893						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		TTGACCTGGAGGTGAAGGCGA	0.512000													48	135					0	0	1	0	0
GKN1	56287	broad.mit.edu	37	2	69204640	69204640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:69204640G>A	ENST00000377938.2	+	2	131	c.68G>A	c.(67-69)gGa>gAa	p.G23E		NM_019617.3	NP_062563.3	Q9NS71	GKN1_HUMAN	gastrokine 1	23					digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						GTCTTTGCTGGACTTCTTGGA	0.368000													36	112					0	0	1	0	0
LGMN	5641	broad.mit.edu	37	14	93179168	93179168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93179168G>A	ENST00000393218.2	-	9	929	c.592C>T	c.(592-594)Ctg>Ttg	p.L198L	LGMN_ENST00000334869.4_Silent_p.L198L|LGMN_ENST00000555699.1_Silent_p.L198L|LGMN_ENST00000557434.1_Silent_p.L198L	NM_001008530.2	NP_001008530.1	Q99538	LGMN_HUMAN	legumain	198					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|skin(2)	18		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		TTATCCGGCAGGTGGTTCATC	0.592000													6	30					0	0	1	0	0
MBTPS2	51360	broad.mit.edu	37	X	21863445	21863445	+	Silent	SNP	C	C	T	rs3834687		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:21863445C>T	ENST00000365779.2	+	3	462	c.381C>T	c.(379-381)tcC>tcT	p.S127S	MBTPS2_ENST00000465888.1_3'UTR|MBTPS2_ENST00000379484.5_Silent_p.S127S			O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase, site 2	127	Poly-Ser.				cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			breast(2)|endometrium(3)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24						cttcctcttcctcttcttcat	0.418000													26	16					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186954048	186954048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186954048G>A	ENST00000296280.6	-	11	1836	c.1611C>T	c.(1609-1611)gcC>gcT	p.A537A	MASP1_ENST00000495249.1_5'UTR|MASP1_ENST00000392472.2_Silent_p.A424A|MASP1_ENST00000337774.5_Intron	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	536	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		GCACCACTCGGGCAGCTGAGC	0.572000													10	69					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242129552	242129552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242129552G>A	ENST00000274979.8	+	2	339	c.236G>A	c.(235-237)aGg>aAg	p.R79K	ANO7_ENST00000402530.3_Missense_Mutation_p.R79K|ANO7_ENST00000402430.3_Missense_Mutation_p.R79K	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	79						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						GCAGAGAAGAGGGGCTCTTAC	0.662000													4	5					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997234	82997234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82997234G>A	ENST00000307792.3	-	17	2463	c.1996C>T	c.(1996-1998)Cgt>Tgt	p.R666C	SEMA3E_ENST00000427262.1_Missense_Mutation_p.R606C	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	666	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GTGATTTTACGGACCGTATGG	0.463000													39	76					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17892613	17892613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17892613C>T	ENST00000594202.1	+	23	2200	c.1921C>T	c.(1921-1923)Cgt>Tgt	p.R641C	FCHO1_ENST00000597512.1_Missense_Mutation_p.R648C|FCHO1_ENST00000596536.1_Missense_Mutation_p.R641C|FCHO1_ENST00000600676.1_Missense_Mutation_p.R641C|FCHO1_ENST00000539407.1_Missense_Mutation_p.R641C|FCHO1_ENST00000596951.1_Missense_Mutation_p.R641C|FCHO1_ENST00000252771.7_Missense_Mutation_p.R641C|FCHO1_ENST00000595033.1_Missense_Mutation_p.R591C|FCHO1_ENST00000389133.4_Missense_Mutation_p.R641C	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	641										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CGCCTACTTCCGTGGCCACAG	0.637000													36	64					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938959	2938959	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2938959G>A	ENST00000378404.2	+	1	914	c.709G>A	c.(709-711)Gag>Aag	p.E237K		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	237						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GAGGCCGGAGGAGGTCCTGAG	0.652000													18	60					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566348	45566348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:45566348C>T	ENST00000588982.1	-	3	1632	c.1131G>A	c.(1129-1131)ggG>ggA	p.G377G	ZBTB7C_ENST00000586438.1_Silent_p.G377G|ZBTB7C_ENST00000535628.2_Silent_p.G377G|ZBTB7C_ENST00000590800.1_Silent_p.G377G|ZBTB7C_ENST00000332053.2_Silent_p.G377G			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	377						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GCGGCAGCTTCCCGGCCCCCA	0.642000													39	86					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118574371	118574371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:118574371C>T	ENST00000336338.5	-	25	3618	c.3553G>A	c.(3553-3555)Gaa>Aaa	p.E1185K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1185						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTGGGTTTTTCTTTGCCTTTT	0.383000													29	126					0	0	1	0	0
PHF8	23133	broad.mit.edu	37	X	54048724	54048724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54048724G>A	ENST00000338154.6	-	4	765	c.261C>T	c.(259-261)ttC>ttT	p.F87F	PHF8_ENST00000322659.8_Silent_p.F87F|PHF8_ENST00000338946.6_Silent_p.F87F|PHF8_ENST00000357988.5_Silent_p.F123F	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	123					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						GCTCTCTGACGAACGTAGGGC	0.537000													59	44					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12814536	12814536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12814536G>A	ENST00000425528.1	-	19	2459	c.2102C>T	c.(2101-2103)cCc>cTc	p.P701L	TNPO2_ENST00000441499.1_Missense_Mutation_p.P701L|TNPO2_ENST00000588216.1_Missense_Mutation_p.P701L|TNPO2_ENST00000450764.2_Missense_Mutation_p.P701L|TNPO2_ENST00000356861.5_Missense_Mutation_p.P701L|TNPO2_ENST00000592287.1_Missense_Mutation_p.P701L			O14787	TNPO2_HUMAN	transportin 2	701					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						ACCGATACAGGGCTTGACATG	0.577000													3	9					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61533631	61533631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61533631G>A	ENST00000278836.5	+	3	432	c.336G>A	c.(334-336)aaG>aaA	p.K112K	MYRF_ENST00000265460.5_Silent_p.K103K	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		CTGCCCCCAAGCCCTTCCCGG	0.701000													19	45					0	0	1	0	0
IGFALS	3483	broad.mit.edu	37	16	1841107	1841107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1841107C>T	ENST00000415638.3	-	2	1505	c.1426G>A	c.(1426-1428)Gag>Aag	p.E476K	IGFALS_ENST00000215539.3_Missense_Mutation_p.E438K	NM_001146006.1|NM_004970.2	NP_001139478.1|NP_004961.1	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	438					cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						AGGTCGAGCTCCAGCAGCTCC	0.682000													3	20					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67092929	67092929	+	Missense_Mutation	SNP	G	G	A	rs138992705	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67092929G>A	ENST00000284425.2	-	24	3308	c.3134C>T	c.(3133-3135)tCc>tTc	p.S1045F	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1045					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CCATAGCTGGGACTTAGCATT	0.323000													6	52					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21771626	21771626	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21771626G>A	ENST00000206660.6	+	5	724	c.724G>A	c.(724-726)Gag>Aag	p.E242K	RPGRIP1_ENST00000557771.1_Missense_Mutation_p.E215K|RPGRIP1_ENST00000556336.1_Missense_Mutation_p.E215K|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.E242K			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	242					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CAAGTCTCCTGAGAAAATGTG	0.478000													26	37					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86590635	86590635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:86590635C>T	ENST00000370571.2	-	3	1750	c.1384G>A	c.(1384-1386)Gaa>Aaa	p.E462K	COL24A1_ENST00000436319.1_Missense_Mutation_p.E462K	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	462					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TAGCTATTTTCGATGGGATAA	0.368000													16	68					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420887	55420887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55420887C>T	ENST00000242994.3	+	2	1042	c.664C>T	c.(664-666)Ctt>Ttt	p.L222F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	222					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						AACACATCTCCTTCATCTCAA	0.498000													26	70					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48602556	48602556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48602556G>A	ENST00000328333.8	-	116	8713	c.8606C>T	c.(8605-8607)cCt>cTt	p.P2869L	COL7A1_ENST00000454817.1_Missense_Mutation_p.P2837L	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2869	Nonhelical region (NC2).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACTATCCCAAGGAGCTTCAGG	0.612000													5	32					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854449	12854449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12854449C>T	ENST00000332296.7	+	3	776	c.673C>T	c.(673-675)Cgt>Tgt	p.R225C		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	225										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAGAAAGCTTCGTTGTTACCT	0.398000													37	770					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236205562	236205562	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:236205562C>T	ENST00000264187.6	-	4	865	c.783G>A	c.(781-783)tgG>tgA	p.W261*	NID1_ENST00000366595.3_Nonsense_Mutation_p.W261*	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	261	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TCTCAAACACCCAGACACCCT	0.552000													70	229					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057713	9057713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9057713C>T	ENST00000397910.4	-	3	29936	c.29733G>A	c.(29731-29733)atG>atA	p.M9911I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9913	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATTTCTGTCATGGAGACTT	0.468000													12	167					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55444993	55444993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55444993C>T	ENST00000588756.1	-	10	3072	c.2586G>A	c.(2584-2586)ggG>ggA	p.G862G	NLRP7_ENST00000328092.5_Silent_p.G834G|NLRP7_ENST00000340844.2_Silent_p.G862G|NLRP7_ENST00000448121.2_Silent_p.G834G|NLRP7_ENST00000590030.1_Silent_p.G862G|NLRP7_ENST00000592784.1_Silent_p.G862G|NLRP7_ENST00000446217.1_Silent_p.G890G			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	862							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GAAACTTCACCCCTGTATCCC	0.507000													25	63					0	0	1	0	0
C6orf58	352999	broad.mit.edu	37	6	127898505	127898505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:127898505G>A	ENST00000329722.7	+	1	187	c.175G>A	c.(175-177)Gag>Aag	p.E59K	C6orf58_ENST00000498112.1_Intron	NM_001010905.1	NP_001010905.1	Q6P5S2	CF058_HUMAN	chromosome 6 open reading frame 58	59						extracellular region				kidney(3)|large_intestine(3)|liver(1)|lung(7)|pancreas(1)	15				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		GGTATACCTTGAGAGAATGGG	0.438000													55	63					0	0	1	0	0
PPAP2C	8612	broad.mit.edu	37	19	288132	288132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:288132G>A	ENST00000269812.3	-	2	141	c.92C>T	c.(91-93)cCg>cTg	p.P31L	PPAP2C_ENST00000434325.2_5'UTR|PPAP2C_ENST00000327790.3_Missense_Mutation_p.P52L	NM_003712.2|NM_177526.1	NP_003703.1|NP_803545.1	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C	31					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(1)|lung(1)|skin(1)	5		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGCTTGTACGGGGCGTTCAC	0.627000													36	77					0	0	1	0	0
SULT2B1	6820	broad.mit.edu	37	19	49055564	49055564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49055564G>A	ENST00000201586.2	+	1	233	c.55G>A	c.(55-57)Gac>Aac	p.D19N		NM_177973.1	NP_814444.1	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	19					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	11		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		CTATGAAGATGACATCTCGGA	0.672000													8	25					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78413252	78413252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78413252G>A	ENST00000278550.7	-	28	4868	c.4406C>T	c.(4405-4407)tCa>tTa	p.S1469L		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AGCGGTGGCTGACTCCAGGGT	0.567000													10	23					0	0	1	0	0
TOX4	9878	broad.mit.edu	37	14	21945658	21945658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21945658C>T	ENST00000405508.1	+	3	286	c.10C>T	c.(10-12)Ccc>Tcc	p.P4S	TOX4_ENST00000448790.2_Intron|TOX4_ENST00000262709.3_Missense_Mutation_p.P4S|TOX4_ENST00000494242.1_3'UTR			O94842	TOX4_HUMAN	TOX high mobility group box family member 4	4						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			large_intestine(8)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		TTTCCAGTTTCCCGGAGGAAA	0.592000											OREG0022569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	131					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219492822	219492822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219492822C>T	ENST00000450993.2	+	7	1182	c.843C>T	c.(841-843)ttC>ttT	p.F281F	PLCD4_ENST00000432688.1_Silent_p.F281F|PLCD4_ENST00000417849.1_Silent_p.F281F	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	281					intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GAGACATCTTCAACCCAGCCT	0.522000													25	78					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31422419	31422419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31422419C>T	ENST00000389202.2	+	13	1428	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	460					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TTCGGGGCCTCCCTCTGCTCT	0.667000													18	116					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702044	181702044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:181702044C>T	ENST00000526775.1	+	19	2930	c.2765C>T	c.(2764-2766)tCt>tTt	p.S922F	CACNA1E_ENST00000367570.1_Missense_Mutation_p.S941F|CACNA1E_ENST00000367567.4_Missense_Mutation_p.S548F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.S922F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.S892F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.S873F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.S941F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	941					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CGGAGCAGGTCTGCCAGCCAG	0.632000													38	91					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047037	42047037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:42047037G>A	ENST00000372584.1	-	3	4446	c.3432C>T	c.(3430-3432)tcC>tcT	p.S1144S	HIVEP3_ENST00000429157.2_Silent_p.S1144S|HIVEP3_ENST00000372583.1_Silent_p.S1144S|HIVEP3_ENST00000247584.5_Silent_p.S1144S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1144					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGAGAAAAGGGAGACTGGTG	0.587000													51	111					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328824	57328824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57328824C>T	ENST00000326441.9	-	10	1349	c.986G>A	c.(985-987)gGa>gAa	p.G329E	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.G205E|PEG3_ENST00000593695.1_Missense_Mutation_p.G203E|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.G329E	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	329					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCTTGCTCTTCCCGATTTGGA	0.468000													15	68					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58077194	58077194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58077194C>T	ENST00000219271.3	+	8	2169	c.1384C>T	c.(1384-1386)Ccc>Tcc	p.P462S		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	462	Hemopexin-like 2.				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						CCTGGGCATCCCCTATGACCG	0.632000													3	9					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29608128	29608128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29608128G>A	ENST00000431530.3	+	2	2400	c.2342G>A	c.(2341-2343)gGa>gAa	p.G781E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	771	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CCCCAGCTAGGATTGGGTGCA	0.507000													18	50					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187201178	187201178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187201178C>T	ENST00000264692.4	+	8	945	c.612C>T	c.(610-612)ctC>ctT	p.L204L	F11_ENST00000403665.2_Silent_p.L256L			P03951	FA11_HUMAN	coagulation factor XI	256	Apple 3.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	ATCTTTGTCTCCTTAAAACAT	0.373000													29	75					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101776545	101776545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:101776545C>T	ENST00000334289.3	-	4	870	c.275G>A	c.(274-276)aGa>aAa	p.R92K		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	92					signal transduction	extracellular space	receptor binding	p.R92I(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		TTTGGTACTTCTTGTGTAGGA	0.274000													13	46					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201355640	201355640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201355640C>T	ENST00000391967.2	-	3	1150	c.849G>A	c.(847-849)agG>agA	p.R283R	LAD1_ENST00000367313.3_Silent_p.R297R	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	283						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						AGGCTGTGGCCCTCTTTGGGG	0.632000													31	110					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91795141	91795141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91795141C>T	ENST00000394232.1	+	3	1014	c.544C>T	c.(544-546)Ctg>Ttg	p.L182L	SV2B_ENST00000545111.2_Silent_p.L31L|SV2B_ENST00000557291.1_3'UTR|SV2B_ENST00000330276.4_Silent_p.L182L	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	182					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CAGCATGTCTCTGGCCGTCAA	0.562000													11	155					0	0	1	0	0
SETMAR	6419	broad.mit.edu	37	3	4354988	4354988	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:4354988C>T	ENST00000358065.4	+	2	630	c.563C>T	c.(562-564)tCc>tTc	p.S188F	SUMF1_ENST00000534863.1_Intron|SETMAR_ENST00000430981.1_Missense_Mutation_p.S188F|SETMAR_ENST00000425863.1_Intron	NM_006515.3	NP_006506.3	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion gene	175	Histone-lysine N-methyltransferase.|SET.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)	9		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		CAAACAAAATCCGACTCCAAT	0.363000								Chromatin Structure					26	71					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354698	45354698	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:45354698C>T	ENST00000359271.2	+	2	1273	c.1023C>T	c.(1021-1023)ctC>ctT	p.L341L		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	341						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				AGACAGGCCTCCCTGGAGACT	0.597000													20	63					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1655922	1655922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:1655922C>T	ENST00000324015.3	+	9	978	c.901C>T	c.(901-903)Ctt>Ttt	p.L301F	SERPINF2_ENST00000450523.2_Missense_Mutation_p.L237F|SERPINF2_ENST00000382061.4_Missense_Mutation_p.L301F	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	301					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	CTTTGTGGTCCTTGTACCCAC	0.547000													6	79					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31588337	31588337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:31588337G>A	ENST00000379416.3	-	23	2578	c.2530C>T	c.(2530-2532)Ctg>Ttg	p.L844L		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	844					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TATCTGGCCAGGAAGGGATGT	0.577000													33	100					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57290806	57290806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57290806G>A	ENST00000391708.3	-	11	1223	c.681C>T	c.(679-681)cgC>cgT	p.R227R	ZIM2_ENST00000221722.5_Silent_p.R227R|ZIM2_ENST00000601070.1_Silent_p.R227R|ZIM2_ENST00000599935.1_Silent_p.R227R|AC006115.3_ENST00000597946.1_RNA|ZIM2_ENST00000593711.1_Silent_p.R227R|AC006115.3_ENST00000594400.1_RNA|AC006115.3_ENST00000595954.1_RNA	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		CCTCTTCCAGGCGTGAGATAA	0.507000													32	97					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30705252	30705252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:30705252C>T	ENST00000256246.2	-	1	1356	c.1282G>A	c.(1282-1284)Gaa>Aaa	p.E428K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	428										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GGTTCATTTTCATTTTTCCTA	0.338000													41	151					0	0	1	0	0
PFKFB3	5209	broad.mit.edu	37	10	6261655	6261655	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:6261655A>G	ENST00000379775.4	+	7	952	c.623_splice	c.e7+1	p.R208_splice	PFKFB3_ENST00000317350.4_Splice_Site_p.R208_splice|PFKFB3_ENST00000379782.3_Splice_Site_p.R208_splice|PFKFB3_ENST00000379789.4_Splice_Site_p.R188_splice|PFKFB3_ENST00000360521.2_Splice_Site_p.R208_splice|PFKFB3_ENST00000379785.1_Splice_Site_p.R208_splice|PFKFB3_ENST00000536985.1_3'UTR|PFKFB3_ENST00000540253.1_Splice_Site_p.R222_splice	NM_004566.3	NP_004557.1	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	208	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|liver(2)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)	22						CAAATGCGACAGGTGATTCCC	0.502000													16	66					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55027323	55027323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:55027323G>A	ENST00000324000.3	+	4	2992	c.958G>A	c.(958-960)Gga>Aga	p.G320R		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	320					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CCACTTGTATGGATTTTGGCC	0.423000													16	51					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983180	97983180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97983180G>A	ENST00000383696.2	+	1	93	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TGAGGAGATGGAAGAGGAAAA	0.388000													73	153					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39039051	39039051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39039051C>T	ENST00000355481.4	+	88	12389	c.12258C>T	c.(12256-12258)gaC>gaT	p.D4086D	RYR1_ENST00000359596.3_Silent_p.D4091D|RYR1_ENST00000360985.3_Silent_p.D4086D	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4091					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCAAGAAGGACTTCCAGAAGG	0.572000													40	69					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158225851	158225851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158225851G>A	ENST00000289429.5	+	3	916	c.383G>A	c.(382-384)gGa>gAa	p.G128E		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	128					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	AAGGTCTCAGGAAGCTTCTTG	0.438000													31	106					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48736816	48736816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48736816C>T	ENST00000316623.5	-	49	6414	c.5959G>A	c.(5959-5961)Ggt>Agt	p.G1987S		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1987	EGF-like 34; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGACAGGTACCTGGTGCACAT	0.423000													33	125					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7695297	7695297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7695297G>A	ENST00000572933.1	+	45	8423	c.6963G>A	c.(6961-6963)atG>atA	p.M2321I	DNAH2_ENST00000389173.2_Missense_Mutation_p.M2321I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2321					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGTTCAGCATGATCTGGTCTG	0.532000													55	78					0	0	1	0	0
IFNA14	3448	broad.mit.edu	37	9	21239414	21239414	+	Missense_Mutation	SNP	G	G	A	rs146172550	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21239414G>A	ENST00000380222.2	-	1	564	c.521C>T	c.(520-522)tCc>tTc	p.S174F		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	174					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AAAAGAGAGGGATCTCATGAT	0.388000													101	355					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52602104	52602104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52602104C>T	ENST00000591504.1	-	7	821	c.547G>A	c.(547-549)Gaa>Aaa	p.E183K	CCDC68_ENST00000337363.4_Missense_Mutation_p.E183K|CCDC68_ENST00000432185.1_Missense_Mutation_p.E183K	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	183										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		CTGTGTTTTTCTTCAAGTTTT	0.358000													25	46					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370850	240370850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240370850C>T	ENST00000319653.9	+	5	2968	c.2738C>T	c.(2737-2739)cCt>cTt	p.P913L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	913	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCCTCCCCCTCCTCTTCCC	0.662000													42	85					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576177	33576177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33576177G>A	ENST00000504830.1	-	19	4289	c.3954C>T	c.(3952-3954)atC>atT	p.I1318I	ADAMTS12_ENST00000352040.3_Silent_p.I1233I	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1318	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						AGTTTCCGACGATCCAGTGTG	0.453000										HNSCC(64;0.19)			40	90					0	0	1	0	0
FAM19A4	151647	broad.mit.edu	37	3	68929890	68929890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:68929890C>T	ENST00000295569.7	-	3	613	c.121G>A	c.(121-123)Gga>Aga	p.G41R		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	41						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		CCTGCATGTCCCCGGAGGTGC	0.478000													18	55					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143747663	143747663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143747663C>T	ENST00000408906.2	+	1	203	c.169C>T	c.(169-171)Ccc>Tcc	p.P57S		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					ACTGCACACCCCCATGTACTT	0.507000													42	94					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152803	18152803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18152803C>T	ENST00000375406.1	+	3	1106	c.890C>T	c.(889-891)gCc>gTc	p.A297V		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	297						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CACGTGATGGCCTGCGGGGGC	0.652000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	66					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896986	175896986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:175896986G>A	ENST00000359240.3	+	5	980	c.310G>A	c.(310-312)Ggt>Agt	p.G104S	ADAM29_ENST00000445694.1_Missense_Mutation_p.G104S|ADAM29_ENST00000404450.4_Missense_Mutation_p.G104S|ADAM29_ENST00000514159.1_Missense_Mutation_p.G104S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	104					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CTACTATCATGGTTATGTGGA	0.438000													21	51					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35752159	35752159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35752159C>T	ENST00000400441.3	-	15	1828	c.1829G>A	c.(1828-1830)cGa>cAa	p.R610Q	MROH8_ENST00000217333.8_Missense_Mutation_p.R439Q|MROH8_ENST00000441008.2_Missense_Mutation_p.R596Q					maestro heat-like repeat family member 8																		CGTAGCTGCTCGAAGCCTGTT	0.483000													6	33					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89251712	89251712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89251712C>T	ENST00000289746.2	+	5	699	c.634C>T	c.(634-636)Cgc>Tgc	p.R212C		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	212	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		AGGAGAGATCCGCACAGTGCA	0.697000													6	3					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103569	53103569	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:53103569G>A	ENST00000408890.4	+	1	221	c.205G>A	c.(205-207)Ggg>Agg	p.G69R		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	69										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CTTCCAGTGGGGGCGCCCGGT	0.706000													6	64					0	0	1	0	0
B3GNT5	84002	broad.mit.edu	37	3	182988250	182988250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:182988250C>T	ENST00000326505.3	+	2	1194	c.664C>T	c.(664-666)Cgt>Tgt	p.R222C	MCF2L2_ENST00000328913.3_Intron|MCF2L2_ENST00000447025.2_Intron|B3GNT5_ENST00000460419.1_Missense_Mutation_p.R222C|MCF2L2_ENST00000473233.1_Intron|B3GNT5_ENST00000465010.1_Missense_Mutation_p.R222C	NM_032047.4	NP_114436.1	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	222					central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TTGGATTGGTCGTGTTCATCG	0.423000													64	165					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113286201	113286201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113286201C>T	ENST00000362072.3	-	5	1009	c.665G>A	c.(664-666)cGa>cAa	p.R222Q	DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000346454.3_Missense_Mutation_p.R222Q|DRD2_ENST00000542968.1_Missense_Mutation_p.R222Q|DRD2_ENST00000538967.1_Missense_Mutation_p.R222Q|DRD2_ENST00000355319.2_Missense_Mutation_p.R222Q|DRD2_ENST00000544518.1_Missense_Mutation_p.R221Q	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	222	Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGTGTTGACTCGCTTGCGGCG	0.567000													44	138					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586117	20586117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20586117C>T	ENST00000315543.4	+	1	552	c.552C>T	c.(550-552)ctC>ctT	p.L184L		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TCTTGGGTCTCCTTCACTCAG	0.448000													39	79					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37689061	37689061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:37689061C>T	ENST00000315215.7	+	8	1416	c.1053C>T	c.(1051-1053)tcC>tcT	p.S351S	GPR124_ENST00000412232.2_Silent_p.S351S			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	351					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCTCTGCCTCCTACTGCCCCG	0.662000													12	31					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36651812	36651812	+	Missense_Mutation	SNP	C	C	T	rs140963190		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:36651812C>T	ENST00000543751.1	+	11	1040	c.895C>T	c.(895-897)Cgt>Tgt	p.R299C	MELK_ENST00000538311.1_Missense_Mutation_p.R137C|MELK_ENST00000298048.2_Missense_Mutation_p.R331C|MELK_ENST00000541717.1_Missense_Mutation_p.R331C|MELK_ENST00000536860.1_Missense_Mutation_p.R283C|MELK_ENST00000545008.1_Missense_Mutation_p.R260C|MELK_ENST00000536987.1_Missense_Mutation_p.R200C|MELK_ENST00000536329.1_Missense_Mutation_p.R260C	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	331						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			AAAACCAGTTCGTTTAAGGCT	0.468000													109	224					0	0	1	0	0
PPAP2C	8612	broad.mit.edu	37	19	282190	282190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:282190G>A	ENST00000269812.3	-	5	710	c.661C>T	c.(661-663)Cac>Tac	p.H221Y	PPAP2C_ENST00000434325.2_Missense_Mutation_p.H165Y|PPAP2C_ENST00000327790.3_Missense_Mutation_p.H242Y	NM_003712.2|NM_177526.1	NP_003703.1|NP_803545.1	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C	221					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(1)|lung(1)|skin(1)	5		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGCTCCAGTGGTGTTTGTAA	0.587000													18	33					0	0	1	0	0
IGHV3-7	28452	broad.mit.edu	37	14	106518487	106518487	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106518487G>A	ENST00000390598.2	-	0	342																											CTCTGGAGATGGTGAATCGGC	0.542000													126	281					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94028396	94028396	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94028396G>A	ENST00000297268.6	+	4	603	c.132_splice	c.e4+1	p.R44_splice		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	44					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GTGGAGAAAGGGTGTGTAATT	0.373000										HNSCC(75;0.22)			40	100					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196398761	196398761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:196398761G>A	ENST00000367433.5	-	9	866	c.765C>T	c.(763-765)tcC>tcT	p.S255S	KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000367431.4_Silent_p.S255S|KCNT2_ENST00000294725.8_Silent_p.S255S|KCNT2_ENST00000451324.2_Intron			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	255						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CAAAAAGCTTGGAGGACCATG	0.403000													27	67					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53519041	53519041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:53519041C>T	ENST00000370905.3	-	2	1170	c.1030G>A	c.(1030-1032)Gga>Aga	p.G344R	KLHL31_ENST00000407079.1_Missense_Mutation_p.G344R	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					TTGCTCCATCCATTTTCAGGG	0.498000													28	79					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417779	150417779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150417779G>A	ENST00000307194.5	+	3	827	c.687G>A	c.(685-687)caG>caA	p.Q229Q		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCTGGCGCAGGTGCTGCGCT	0.706000													5	11					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19576956	19576956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:19576956C>T	ENST00000341998.2	-	5	1255	c.1194G>A	c.(1192-1194)gaG>gaA	p.E398E	SLC24A2_ENST00000286344.3_Silent_p.E381E	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	398					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GCCTCTCGTTCTCATCCACAT	0.522000													50	77					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148930248	148930248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:148930248C>T	ENST00000264613.6	-	2	646	c.384G>A	c.(382-384)aaG>aaA	p.K128K		NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	128	F5/8 type A 1.|Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	CCTCATGTTCCTTATAGTAAG	0.373000													9	73					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169589453	169589453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169589453C>T	ENST00000261509.6	+	3	1232	c.1021C>T	c.(1021-1023)Cgc>Tgc	p.R341C	PALLD_ENST00000333488.4_Missense_Mutation_p.R218C|PALLD_ENST00000512127.1_5'UTR|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Missense_Mutation_p.R341C	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	341	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CGACACAGGTCGCTACACCTG	0.522000									Pancreatic Cancer, Familial Clustering of				11	92					0	0	1	0	0
ZNF584	201514	broad.mit.edu	37	19	58928497	58928497	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58928497C>T	ENST00000306910.4	+	4	1135	c.612C>T	c.(610-612)ccC>ccT	p.P204P	ZNF584_ENST00000593920.1_Silent_p.P159P|ZNF584_ENST00000599238.1_3'UTR	NM_173548.1	NP_775819.1	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		ATATTAACCCCCGAAAAATTC	0.478000													12	42					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7806009	7806009	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:7806009C>T	ENST00000303635.7	+	18	4682	c.4475C>T	c.(4474-4476)gCc>gTc	p.A1492V	CAMTA1_ENST00000476864.1_Missense_Mutation_p.A56V|CAMTA1_ENST00000439411.2_Missense_Mutation_p.A1478V	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CTTCCCTCCGCCGCGGATTGG	0.488000			T	WWTR1	epitheliod hemangioendothelioma								27	124					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80874910	80874910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:80874910C>T	ENST00000466387.1	+	22	3355	c.2631C>T	c.(2629-2631)ttC>ttT	p.F877F	CTNNA2_ENST00000402739.4_Silent_p.F925F|CTNNA2_ENST00000361291.4_Silent_p.F911F|CTNNA2_ENST00000496558.1_Silent_p.F877F|CTNNA2_ENST00000540488.1_Silent_p.F832F|CTNNA2_ENST00000343114.3_Silent_p.F556F|CTNNA2_ENST00000541047.1_Silent_p.F877F			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	925					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CTGAAGAATTCCAGACACGAG	0.458000													49	189					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179638652	179638652	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179638652C>T	ENST00000589042.1	-	31	7467	c.7243G>A	c.(7243-7245)Gaa>Aaa	p.E2415K	TTN_ENST00000342992.6_Missense_Mutation_p.E2415K|TTN_ENST00000360870.5_Missense_Mutation_p.E2415K|TTN_ENST00000591111.1_Missense_Mutation_p.E2415K|TTN_ENST00000342175.6_Missense_Mutation_p.E2369K|TTN_ENST00000359218.5_Missense_Mutation_p.E2369K|TTN-AS1_ENST00000584485.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E2369K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2139	Ig-like 13.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E2415Q(3)|p.E2369Q(3)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCATGTCTTCAATGAGCAGC	0.478000													34	109					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4947742	4947742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:4947742C>T	ENST00000345988.2	-	9	995	c.906G>A	c.(904-906)tgG>tgA	p.W302*	PPL_ENST00000590782.2_Nonsense_Mutation_p.W300*	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	302					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GGTACTCCTTCCAGTCTGCGT	0.607000													19	29					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160786439	160786439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160786439C>T	ENST00000263285.5	+	5	1158	c.1128C>T	c.(1126-1128)atC>atT	p.I376I	LY9_ENST00000368035.1_Silent_p.I28I|LY9_ENST00000368041.2_Intron|LY9_ENST00000341032.4_Intron|LY9_ENST00000368040.1_Silent_p.I28I	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	376	Ig-like C2-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGGATGGCATCTGCAGGATCA	0.592000													8	21					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73046169	73046169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:73046169G>A	ENST00000261180.4	+	16	2704	c.2608G>A	c.(2608-2610)Gaa>Aaa	p.E870K		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	870					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GGATGTCTGGGAATTCATATG	0.378000													28	84					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125530386	125530386	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:125530386G>A	ENST00000431078.1	+	17	2905	c.2541G>A	c.(2539-2541)gaG>gaA	p.E847E		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	847	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTCCTTCAGAGATCACCTTTG	0.488000													17	68					0	0	1	0	0
TNNI3	7137	broad.mit.edu	37	19	55666111	55666111	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55666111C>T	ENST00000344887.5	-	6	512	c.370G>A	c.(370-372)Gag>Aag	p.E124K	TNNI3_ENST00000588882.1_Missense_Mutation_p.E99K	NM_000363.4	NP_000354.4	P19429	TNNI3_HUMAN	troponin I type 3 (cardiac)	124					cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CGTCCCACCTCCGTGATGTTC	0.582000													5	18					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98421634	98421634	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:98421634C>T	ENST00000186436.5	-	22	2547	c.2319G>A	c.(2317-2319)caG>caA	p.Q773Q		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	773						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						ACATATCTTCCTGCATGGCTA	0.408000													6	30					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579461	55579461	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55579461G>A	ENST00000333973.2	+	1	608	c.519G>A	c.(517-519)gtG>gtA	p.V173V		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				GATCTAATGTGATTAACCACT	0.453000													80	223					0	0	1	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48896915	48896915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:48896915G>A	ENST00000394754.1	+	9	3259	c.3145G>A	c.(3145-3147)Gaa>Aaa	p.E1049K	GTF2A1L_ENST00000430487.2_Missense_Mutation_p.E311K|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.E1049K|GTF2A1L_ENST00000403751.3_Missense_Mutation_p.E345K|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.E1049K|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.E1002K|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.E1049K	NM_172311.2	NP_758515.1	B7ZL16	B7ZL16_HUMAN		1002					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(22)|liver(2)|lung(49)|ovary(3)|pancreas(1)|prostate(4)|skin(4)	91		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TGATATTGGTGAAATAATTCA	0.338000													58	137					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171083178	171083178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171083178G>A	ENST00000367755.4	+	7	970	c.859G>A	c.(859-861)Gag>Aag	p.E287K	FMO3_ENST00000538429.1_Missense_Mutation_p.E224K|FMO3_ENST00000392085.2_Missense_Mutation_p.E287K|FMO3_ENST00000542847.1_Missense_Mutation_p.E267K	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	287					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTTAACGATGAGCTCCCAGC	0.413000													22	48					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120502576	120502576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:120502576C>T	ENST00000397558.2	+	4	802	c.802C>T	c.(802-804)Cgt>Tgt	p.R268C	CCDC64_ENST00000446727.2_Missense_Mutation_p.R12C	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	268					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGGAGCATCGTCTCAGCGC	0.567000													19	138					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56334725	56334725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56334725C>T	ENST00000331886.5	+	13	1516	c.1062C>T	c.(1060-1062)acC>acT	p.T354T	DGKA_ENST00000394147.1_Silent_p.T354T|DGKA_ENST00000551156.1_Silent_p.T354T|DGKA_ENST00000549079.2_3'UTR	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	354					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	GCCAGAAGACCATGGATGATT	0.493000											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	49					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417157	150417157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150417157C>T	ENST00000307194.5	+	3	205	c.65C>T	c.(64-66)tCc>tTc	p.S22F		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1									p.S22Y(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AACGCTCAGTCCCGGCAGGAG	0.527000													96	289					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098263	144098263	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:144098263C>T	ENST00000467773.1	-	4	719	c.720G>A	c.(718-720)ggG>ggA	p.G240G	NOBOX_ENST00000223140.5_Silent_p.G155G|NOBOX_ENST00000483238.1_Silent_p.G240G	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	240					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					GGTGGCAGGGCCCCCGGCCTG	0.597000													11	17					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35131484	35131484	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:35131484G>A	ENST00000436258.1	-	0	1885																											TCGTAAAGTGGATGATTCACA	0.418000													23	63					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16034646	16034646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16034646G>A	ENST00000326742.7	-	6	895	c.894C>T	c.(892-894)ttC>ttT	p.F298F	CYP4F11_ENST00000402119.3_Silent_p.F298F|CYP4F11_ENST00000248041.7_Silent_p.F298F			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	298					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						GCACATCAATGAAGTCTAAAG	0.463000													50	167					0	0	1	0	0
OR10H1	26539	broad.mit.edu	37	19	15918696	15918696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15918696C>T	ENST00000334920.2	-	1	240	c.152G>A	c.(151-153)aGc>aAc	p.S51N		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						GCTGCGCTCGCTCCAGACGGT	0.622000													36	69					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115341664	115341664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115341664G>A	ENST00000351270.3	+	9	964	c.868G>A	c.(868-870)Gag>Aag	p.E290K	HABP2_ENST00000542051.1_Missense_Mutation_p.E264K|HABP2_ENST00000541666.1_Intron	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	290					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		AAGCCCCACTGAGCCATCAAC	0.527000													58	162					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936890	15936890	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:15936890C>T	ENST00000504595.1	+	4	1552	c.1071C>T	c.(1069-1071)atC>atT	p.I357I	FBXL7_ENST00000510662.1_Silent_p.I310I|FBXL7_ENST00000329673.7_Silent_p.I345I	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	357					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.I357I(1)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						ACCTGAGCATCGCGCACTGCG	0.672000													6	20					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20620505	20620505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:20620505G>A	ENST00000504154.1	+	37	4715	c.4463G>A	c.(4462-4464)gGa>gAa	p.G1488E	SLIT2_ENST00000273739.5_Missense_Mutation_p.G1501E|SLIT2_ENST00000503823.1_Missense_Mutation_p.G1480E|SLIT2_ENST00000503837.1_Missense_Mutation_p.G1484E	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1488	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GGGTGTGCAGGAGGGCAGTGC	0.532000													20	33					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73844510	73844510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73844510G>A	ENST00000334126.7	-	6	1274	c.1048C>T	c.(1048-1050)Cat>Tat	p.H350Y	C2CD3_ENST00000313663.7_Missense_Mutation_p.H350Y|C2CD3_ENST00000539061.1_Missense_Mutation_p.H350Y			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	350						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					ATAGGAGGATGAACTTGGTCC	0.393000													14	56					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2716283	2716283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2716283G>A	ENST00000399655.1	+	26	3608	c.3343G>A	c.(3343-3345)Gaa>Aaa	p.E1115K	CACNA1C_ENST00000347598.4_Missense_Mutation_p.E1135K|CACNA1C_ENST00000399591.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000480911.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000344100.3_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399597.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000335762.5_Missense_Mutation_p.E1140K|CACNA1C_ENST00000399595.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399603.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399617.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399606.1_Missense_Mutation_p.E1135K|CACNA1C_ENST00000399621.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399601.1_Missense_Mutation_p.E1115K|CACNA1C-AS3_ENST00000543559.1_RNA|CACNA1C_ENST00000399638.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399649.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399644.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399629.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000327702.7_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399634.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399637.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000406454.3_Missense_Mutation_p.E1115K|CACNA1C_ENST00000402845.3_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399641.1_Missense_Mutation_p.E1115K	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1135	Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CTCCACCTTCGAAGGGTGGCC	0.542000													7	16					0	0	1	0	0
PPT1	5538	broad.mit.edu	37	1	40555170	40555170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40555170G>A	ENST00000433473.3	-	5	912	c.448C>T	c.(448-450)Cct>Tct	p.P150S	PPT1_ENST00000449045.2_Missense_Mutation_p.P47S	NM_000310.3	NP_000301.1	P50897	PPT1_HUMAN	palmitoyl-protein thioesterase 1	150					brain development|cofactor metabolic process|cofactor transport|DNA fragmentation involved in apoptotic nuclear change|lysosomal lumen acidification|membrane raft organization|negative regulation of cell growth|negative regulation of neuron apoptosis|neuron development|pinocytosis|positive regulation of pinocytosis|positive regulation of receptor-mediated endocytosis|protein depalmitoylation|protein transport|receptor-mediated endocytosis|regulation of synapse structure and activity|sphingolipid catabolic process|visual perception	axon|cytosol|Golgi apparatus|lysosome|membrane fraction|membrane raft|nucleus|synaptic vesicle	palmitoyl-(protein) hydrolase activity|palmitoyl-CoA hydrolase activity			endometrium(5)|large_intestine(1)|lung(3)|ovary(1)|stomach(1)	11	Lung NSC(20;3.43e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1e-18)|Epithelial(16;3.6e-17)|all cancers(16;1.1e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGGCATCGAGGGAGTCCAAAA	0.443000													18	65					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125288790	125288790	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125288790G>A	ENST00000304880.2	-	1	782	c.783C>T	c.(781-783)ccC>ccT	p.P261P		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						AGGCAATGGAGGGAGGACACA	0.527000													9	58					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49169754	49169754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49169754G>A	ENST00000307885.4	-	8	2492	c.1798C>T	c.(1798-1800)Cgc>Tgc	p.R600C	ADCY6_ENST00000552090.1_5'UTR|ADCY6_ENST00000357869.3_Missense_Mutation_p.R600C|ADCY6_ENST00000550422.1_Missense_Mutation_p.R600C	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	600					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						ACCATCTGGCGGAAGGCCTTG	0.607000													4	11					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31750138	31750138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:31750138G>A	ENST00000446923.2	+	2	571	c.180G>A	c.(178-180)ggG>ggA	p.G60G	ZEB1_ENST00000560721.2_Silent_p.G77G|ZEB1_ENST00000361642.5_Silent_p.G77G|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000542815.3_Intron|ZEB1_ENST00000320985.10_Silent_p.G77G	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	77					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAGAGAAGGGAATGCTAAGA	0.388000													14	39					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57494895	57494895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:57494895C>T	ENST00000351747.2	-	6	694	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	DNAH12_ENST00000311202.6_Missense_Mutation_p.E172K|DNAH12_ENST00000389536.4_Missense_Mutation_p.E172K	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	172	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						GGACCTCCTTCATCTTCAAGC	0.313000													23	75					0	0	1	0	0
KRT7	3855	broad.mit.edu	37	12	52636807	52636807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52636807C>T	ENST00000331817.5	+	6	1053	c.870C>T	c.(868-870)ctC>ctT	p.L290L		NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	290	Coil 2.|Rod.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		TTGAGACCCTCCAGGCCCAGG	0.587000													18	76					0	0	1	0	0
OR1J1	347168	broad.mit.edu	37	9	125239414	125239414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125239414G>A	ENST00000259357.2	-	1	821	c.792C>T	c.(790-792)tcC>tcT	p.S264S		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						TGGTGTTGCTGGATGGGGGAA	0.418000													48	98					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120363267	120363267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120363267G>A	ENST00000283871.5	-	10	1132	c.673C>T	c.(673-675)Cgt>Tgt	p.R225C		NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	225			R -> H (in AKU).		L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		AAGAAATCACGAGGATTGGCC	0.443000													25	66					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887590	97887590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97887590G>A	ENST00000356526.2	+	1	47	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						GTTCTCACAGGATTTTTATAT	0.393000													64	191					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467808	74467808	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74467808G>A	ENST00000249842.3	+	2	966	c.609G>A	c.(607-609)ccG>ccA	p.P203P	ISLR_ENST00000395118.1_Silent_p.P203P|RP11-665J16.1_ENST00000561647.1_RNA	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	203	LRRCT.				cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						TGTCCATCCCGGAGCAGGACA	0.662000													14	49					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89979993	89979993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:89979993G>A	ENST00000405460.2	+	28	6351	c.6255G>A	c.(6253-6255)gcG>gcA	p.A2085A		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2085					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTTAGTAGCGAAAGTACAGA	0.333000													11	20					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160917778	160917778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160917778C>T	ENST00000368029.3	-	7	823	c.766G>A	c.(766-768)Gag>Aag	p.E256K	ITLN2_ENST00000494442.1_5'UTR|RP11-544M22.1_ENST00000356006.3_RNA	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	256	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCTGCTCTCTCGTTATTAAAC	0.463000													12	96					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488490	108488490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108488490C>T	ENST00000408999.3	+	20	4107	c.4030C>T	c.(4030-4032)Cta>Tta	p.L1344L	RGPD4_ENST00000354986.4_Silent_p.L1344L	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1344	RanBD1 2.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TTTACCTGATCTAGTTGAAGT	0.393000													113	278					0	0	1	0	0
ZNF442	79973	broad.mit.edu	37	19	12460892	12460892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12460892G>A	ENST00000242804.4	-	6	2089	c.1507C>T	c.(1507-1509)Ctt>Ttt	p.L503F	ZNF442_ENST00000438182.1_Missense_Mutation_p.L434F	NM_030824.2	NP_110451.1	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	503					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	31						TGTTGAGAAAGGTATGTGAAA	0.353000													36	140					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65417935	65417935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65417935G>A	ENST00000394224.3	+	15	3263	c.2967G>A	c.(2965-2967)caG>caA	p.Q989Q	SIPA1_ENST00000394227.3_Silent_p.Q887Q|SIPA1_ENST00000534313.1_Silent_p.Q989Q|SIPA1_ENST00000527525.1_Silent_p.Q887Q	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	989					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GGAAGCTGCAGGAGGACCTGC	0.632000													15	53					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57815731	57815731	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57815731G>A	ENST00000281282.5	+	11	2838	c.2760G>A	c.(2758-2760)gaG>gaA	p.E920E		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	920						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGTTGTCTGAGAAGCTCAAAG	0.512000													15	29					0	0	1	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37962694	37962694	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37962694C>T	ENST00000249014.4	+	2	758	c.338C>T	c.(337-339)tCc>tTc	p.S113F		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	113					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					CCGGCCATCTCCCCCATCATC	0.682000													40	109					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93819207	93819207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93819207C>T	ENST00000315765.9	+	11	1940	c.1932C>T	c.(1930-1932)tcC>tcT	p.S644S		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	644	Plastocyanin-like 4.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATAGAGTTTCCTGGCATCTGA	0.468000													14	42					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54784155	54784155	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54784155C>T	ENST00000391748.1	-	3	162		c.e3-1		LILRB2_ENST00000391746.1_Splice_Site|LILRB2_ENST00000314446.5_Splice_Site|LILRB2_ENST00000471216.1_5'UTR|LILRB2_ENST00000434421.1_Intron|LILRB2_ENST00000391749.4_Splice_Site	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2						cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGACTCAGCCCTGGAAGAGAG	0.647000													8	115					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72164243	72164243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:72164243C>T	ENST00000537465.1	-	12	1824	c.1666G>A	c.(1666-1668)Gag>Aag	p.E556K	PMFBP1_ENST00000355636.6_Missense_Mutation_p.E406K|PMFBP1_ENST00000237353.10_Missense_Mutation_p.E551K			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	556										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				AATGACAGCTCCTCCACCCGT	0.478000													25	41					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67380159	67380159	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67380159G>A	ENST00000329956.6	+	3	218	c.198_splice	c.e3-1	p.G67_splice	LRRC36_ENST00000563303.1_3'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	67										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TTCCTTGTAGGGAATCCAGTA	0.363000													23	74					0	0	1	0	0
BDH1	622	broad.mit.edu	37	3	197273245	197273245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:197273245C>T	ENST00000392379.1	-	3	471	c.70G>A	c.(70-72)Gaa>Aaa	p.E24K	BDH1_ENST00000392378.2_Missense_Mutation_p.E24K|BDH1_ENST00000441275.1_Intron|BDH1_ENST00000358186.2_Missense_Mutation_p.E24K	NM_203314.2	NP_976059.1	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	24					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	GCTCCATTTTCTCTATCACAG	0.557000													43	39					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227400879	227400879	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:227400879G>A	ENST00000366769.3	-	3	1603	c.312C>T	c.(310-312)gcC>gcT	p.A104A	CDC42BPA_ENST00000366766.2_Silent_p.A104A|CDC42BPA_ENST00000334218.5_Silent_p.A104A|CDC42BPA_ENST00000366764.2_Silent_p.A104A|CDC42BPA_ENST00000535525.1_Silent_p.A104A|CDC42BPA_ENST00000366767.3_Silent_p.A104A|CDC42BPA_ENST00000366765.3_Silent_p.A104A	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	104	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				ATATTTTCATGGCAAACACTT	0.244000													15	108					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461349	11461349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:11461349C>T	ENST00000279575.1	-	3	601	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	PRB4_ENST00000535904.1_Missense_Mutation_p.E190K|PRB4_ENST00000445719.2_Missense_Mutation_p.E121K	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	253	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						TTGTTGCCTTCTTGTTGGGGT	0.602000										HNSCC(22;0.051)			83	252					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179428916	179428916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179428916C>T	ENST00000589042.1	-	326	82167	c.81943G>A	c.(81943-81945)Gaa>Aaa	p.E27315K	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E24747K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E25674K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E18442K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E18375K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E18250K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25674	Fibronectin type-III 99.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCAAGTTCTTTTCCATCT	0.378000													60	177					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641355	179641355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179641355C>T	ENST00000589042.1	-	28	5460	c.5236G>A	c.(5236-5238)Gaa>Aaa	p.E1746K	TTN_ENST00000342992.6_Missense_Mutation_p.E1746K|TTN_ENST00000360870.5_Missense_Mutation_p.E1746K|TTN_ENST00000591111.1_Missense_Mutation_p.E1746K|TTN_ENST00000342175.6_Missense_Mutation_p.E1700K|TTN_ENST00000359218.5_Missense_Mutation_p.E1700K|TTN_ENST00000460472.2_Missense_Mutation_p.E1700K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1500	Ig-like 8.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGCTGCTTCAAGTGGCTTT	0.493000													15	50					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160920888	160920888	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160920888C>T	ENST00000368029.3	-	4	443	c.386G>A	c.(385-387)tGg>tAg	p.W129*		NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	129	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTAGTTGGCCCAGTTGCCATC	0.582000													30	85					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53072446	53072446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53072446G>A	ENST00000252244.3	-	2	744	c.686C>T	c.(685-687)cCc>cTc	p.P229L		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	229	Linker 1.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CTCAAAGTAGGGCTCTAAATT	0.468000													16	100					0	0	1	0	0
ALDH2	217	broad.mit.edu	37	12	112219820	112219820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:112219820G>A	ENST00000546840.2	+	3	203	c.203G>A	c.(202-204)gGg>gAg	p.G68E	ALDH2_ENST00000416293.3_Silent_p.G71G|ALDH2_ENST00000261733.2_Silent_p.G71G																							TAGCTGAAGGGGACAAGGTGA	0.448000													15	47					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62423883	62423883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:62423883G>A	ENST00000383710.4	-	28	4022	c.3673C>T	c.(3673-3675)Ccc>Tcc	p.P1225S	CADPS_ENST00000283269.9_Missense_Mutation_p.P1186S|CADPS_ENST00000357948.3_Missense_Mutation_p.P1146S	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1225	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCCATCCCGGGTTTCTGTAAA	0.468000													18	45					0	0	1	0	0
RAB27B	5874	broad.mit.edu	37	18	52556597	52556597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:52556597G>A	ENST00000262094.5	+	6	1131	c.610G>A	c.(610-612)Gga>Aga	p.G204R	RP11-839G9.1_ENST00000588466.1_RNA	NM_004163.4	NP_004154.2	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	204					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity			large_intestine(3)|lung(3)|skin(1)	7				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		TGGAAATTCTGGAAACTTGGA	0.398000													25	62					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56385698	56385698	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:56385698G>A	ENST00000423270.1	-	9	4227	c.4228C>T	c.(4228-4230)Cgt>Tgt	p.R1410C	RFX7_ENST00000317318.6_Intron|RFX7_ENST00000559447.2_Missense_Mutation_p.R1313C|RFX7_ENST00000422057.1_Intron	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	1313					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CCCTGCTGACGACCTGGATCA	0.398000													13	44					0	0	1	0	0
MAP7D2	256714	broad.mit.edu	37	X	20081589	20081589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:20081589C>T	ENST00000379651.3	-	3	333	c.315G>A	c.(313-315)gaG>gaA	p.E105E	MAP7D2_ENST00000452324.3_Silent_p.E61E|MAP7D2_ENST00000443379.3_Silent_p.E105E|MAP7D2_ENST00000379643.5_Silent_p.E105E	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	105										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						TCTTTTGGTCCTCCCGCTGCC	0.577000													31	21					0	0	1	0	0
FAM154B	283726	broad.mit.edu	37	15	82574877	82574877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:82574877C>T	ENST00000339465.5	+	3	740	c.671C>T	c.(670-672)cCa>cTa	p.P224L	FAM154B_ENST00000427381.2_Missense_Mutation_p.P209L|FAM154B_ENST00000565501.1_3'UTR	NM_001008226.1	NP_001008227.1	Q658L1	F154B_HUMAN	family with sequence similarity 154, member B	224										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						AGTTTTCAACCATGGGAAATC	0.463000													26	99					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37871608	37871608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37871608C>T	ENST00000406381.2	+	12	1638	c.1128C>T	c.(1126-1128)atC>atT	p.I376I	ERBB2_ENST00000445658.2_Silent_p.I130I|ERBB2_ENST00000269571.5_Silent_p.I406I|ERBB2_ENST00000540147.1_Silent_p.I376I|ERBB2_ENST00000578199.1_Silent_p.I376I|ERBB2_ENST00000584450.1_Silent_p.I406I|ERBB2_ENST00000584601.1_Silent_p.I376I|ERBB2_ENST00000540042.1_Silent_p.I376I|ERBB2_ENST00000541774.1_Silent_p.I391I	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	406					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TGGAAGAGATCACAGGTGGGC	0.592000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			14	24					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201035010	201035010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201035010G>A	ENST00000362061.3	-	22	3035	c.2809C>T	c.(2809-2811)Ctc>Ttc	p.L937F	CACNA1S_ENST00000367338.3_Missense_Mutation_p.L937F	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	937					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AACTGTAGGAGGGTAGTGACC	0.647000													10	24					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89878700	89878700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:89878700G>A	ENST00000345097.4	-	2	237	c.121C>T	c.(121-123)Ctc>Ttc	p.L41F	FOXN3_ENST00000557258.1_Missense_Mutation_p.L41F|FOXN3_ENST00000261302.5_Missense_Mutation_p.L41F|RP11-33N16.3_ENST00000555070.1_RNA|FOXN3_ENST00000555353.1_Missense_Mutation_p.L41F	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	41					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GAAAAGTCGAGGTCATCGTCT	0.522000													54	101					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71478775	71478775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71478775G>A	ENST00000265382.3	+	5	397	c.92G>A	c.(91-93)gGt>gAt	p.G31D	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.G31D	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	31	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		GCTATTAAAGGTGCTATTCAG	0.423000													36	149					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	145001	145001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145001C>T	ENST00000283426.6	+	4	853	c.803C>T	c.(802-804)gCc>gTc	p.A268V		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	268					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGTCCAGCTGCCCCTGCCGTC	0.607000													15	36					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28971156	28971156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28971156C>T	ENST00000359747.4	+	7	829	c.800C>T	c.(799-801)cCc>cTc	p.P267L	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.P267L|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	267	Cadherin 2.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GATAATTTCCCCACCTTAGAG	0.398000													20	81					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77270191	77270191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77270191G>A	ENST00000251089.2	-	6	1557	c.1445C>T	c.(1444-1446)cCc>cTc	p.P482L	ANGEL1_ENST00000557179.1_Missense_Mutation_p.P47L	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	482										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CAGGGAGCTGGGCCACAGTGG	0.527000													60	147					0	0	1	0	0
TMEM211	255349	broad.mit.edu	37	22	25334143	25334143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25334143G>A	ENST00000407886.1	-	3	352	c.100C>T	c.(100-102)Cca>Tca	p.P34S	TMEM211_ENST00000423535.1_Missense_Mutation_p.P105S|TMEM211_ENST00000382744.1_Missense_Mutation_p.P34S			Q6ICI0	TM211_HUMAN	transmembrane protein 211	105						integral to membrane				endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						CCTGGCATTGGAACACTGCTT	0.512000													14	77					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150698983	150698983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150698983C>T	ENST00000297494.3	+	13	1934	c.1577C>T	c.(1576-1578)tCc>tTc	p.S526F	NOS3_ENST00000467517.1_Missense_Mutation_p.S526F|NOS3_ENST00000484524.1_Missense_Mutation_p.S526F|NOS3_ENST00000461406.1_Missense_Mutation_p.S320F	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	526	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CTGTATGGCTCCGAGACCGGC	0.652000													27	49					0	0	1	0	0
TMEM107	84314	broad.mit.edu	37	17	8079185	8079185	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8079185G>A	ENST00000316425.5	-	3	276	c.164C>T	c.(163-165)cCt>cTt	p.P55L	TMEM107_ENST00000533070.1_Missense_Mutation_p.P55L|TMEM107_ENST00000431792.2_Intron|TMEM107_ENST00000532998.1_Intron|TMEM107_ENST00000437139.2_Intron|TMEM107_ENST00000449985.2_Intron	NM_032354.3	NP_115730.2	Q6UX40	TM107_HUMAN	transmembrane protein 107	51						integral to membrane				large_intestine(1)|lung(4)|ovary(1)	6						CCTGCAGAGAGGAAGTGGACT	0.602000													45	48					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182444	140182444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140182444C>T	ENST00000522353.2	+	1	1662	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F	PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000532566.2_Silent_p.F554F|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1												p.F554F(2)		NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGTGTTCGTGCTGGACG	0.687000													19	156					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56950108	56950108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56950108G>A	ENST00000497933.1	+	1	888	c.741G>A	c.(739-741)atG>atA	p.M247I		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	217	LRRCT.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						GCTGCACCATGGAACCCCTGC	0.632000													38	102					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038129	75038129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:75038129C>T	ENST00000326665.5	-	14	3483	c.3265G>A	c.(3265-3267)Gaa>Aaa	p.E1089K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1089	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AAAGCATCTTCATCCTTGAGT	0.433000													74	184					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118372518	118372518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118372518C>T	ENST00000534358.1	+	26	6474	c.6451C>T	c.(6451-6453)Ccc>Tcc	p.P2151S	KMT2A_ENST00000354520.4_Missense_Mutation_p.P2110S|KMT2A_ENST00000389506.5_Missense_Mutation_p.P2148S	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GATTCGAACACCCAGTTATTC	0.463000													56	149					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833388	168833388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168833388G>A	ENST00000464456.1	-	7	2908	c.1708C>T	c.(1708-1710)Ccc>Tcc	p.P570S	MECOM_ENST00000433243.2_Missense_Mutation_p.P571S|MECOM_ENST00000472280.1_Missense_Mutation_p.P571S|MECOM_ENST00000392736.3_Missense_Mutation_p.P570S|MECOM_ENST00000494292.1_Missense_Mutation_p.P758S|MECOM_ENST00000468789.1_Missense_Mutation_p.P570S|MECOM_ENST00000264674.3_Missense_Mutation_p.P635S|MECOM_ENST00000460814.1_Missense_Mutation_p.P570S	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GGCTTGGAGGGGACTGGAGTC	0.547000													14	54					0	0	1	0	0
ZP3	7784	broad.mit.edu	37	7	76062806	76062806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76062806G>A	ENST00000416245.1	+	3	1120	c.27G>A	c.(25-27)aaG>aaA	p.K9K	ZP3_ENST00000394857.3_Silent_p.K185K|ZP3_ENST00000336517.4_Silent_p.K134K			P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 (sperm receptor)	185					binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7						ACGCTGAGAAGAGGTCCCCCA	0.597000													6	117					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30066932	30066932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:30066932G>A	ENST00000331968.5	-	16	2428	c.2199C>T	c.(2197-2199)atC>atT	p.I733I	PRKD1_ENST00000415220.2_Silent_p.I741I	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	733	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCTCTCCAATGATCCGGGCAA	0.468000													26	50					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26524815	26524815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:26524815C>T	ENST00000456354.2	+	6	784	c.717C>T	c.(715-717)ttC>ttT	p.F239F		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	239					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGTGCATTCGTGCCCAAGC	0.512000													132	311					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371007	240371007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240371007C>T	ENST00000319653.9	+	5	3125	c.2895C>T	c.(2893-2895)ccC>ccT	p.P965P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	965	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGGCATACCCCTTCCTCCCC	0.701000													26	80					0	0	1	0	0
TROVE2	6738	broad.mit.edu	37	1	193046046	193046046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:193046046C>T	ENST00000432079.1	+	4	695	c.127C>T	c.(127-129)Cgt>Tgt	p.R43C	TROVE2_ENST00000367443.1_Missense_Mutation_p.R318C|TROVE2_ENST00000367441.1_Missense_Mutation_p.R318C|TROVE2_ENST00000400968.2_Missense_Mutation_p.R318C|TROVE2_ENST00000367446.3_Missense_Mutation_p.R318C|TROVE2_ENST00000367445.3_Missense_Mutation_p.R318C|TROVE2_ENST00000460715.2_3'UTR|TROVE2_ENST00000416058.2_Missense_Mutation_p.R43C|TROVE2_ENST00000367444.3_Missense_Mutation_p.R318C			P10155	RO60_HUMAN	TROVE domain family, member 2	318	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						TTTCTAGGCTCGTATACATCC	0.328000													4	41					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124371873	124371873	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124371873G>A	ENST00000287394.5	-	10	1317	c.1210C>T	c.(1210-1212)Cga>Tga	p.R404*	ATAD2_ENST00000534257.1_5'UTR|ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ATTTTCATTCGATCTTTATAA	0.353000													13	60					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152524385	152524385	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152524385C>T	ENST00000427231.2	-	40	4854	c.4652G>A	c.(4651-4653)gGc>gAc	p.G1551D	NEB_ENST00000604864.1_Missense_Mutation_p.G1551D|NEB_ENST00000603639.1_Missense_Mutation_p.G1551D|NEB_ENST00000172853.10_Missense_Mutation_p.G1551D|NEB_ENST00000397345.3_Missense_Mutation_p.G1551D|NEB_ENST00000409198.1_Missense_Mutation_p.G1551D	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1551					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAAATCATAGCCCTTGGCAAT	0.333000													15	37					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81744902	81744902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81744902C>T	ENST00000555447.1	-	6	1165	c.753G>A	c.(751-753)ctG>ctA	p.L251L	STON2_ENST00000556280.1_5'UTR|STON2_ENST00000267540.2_Silent_p.L251L	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	251					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TATTTGGCTTCAGAGGAGAGG	0.502000													10	85					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075383	9075383	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9075383G>A	ENST00000397910.4	-	3	12266	c.12063C>T	c.(12061-12063)agC>agT	p.S4021S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4023	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCATGTAAGGGCTGACGTCCC	0.463000													21	70					0	0	1	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266308	3266308	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3266308G>A	ENST00000576468.1	+	0	418																											ACAAAGGGAAGATGGAAAGCC	0.527000													15	43					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37724314	37724314	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:37724314G>A	ENST00000539465.1	+	7	1202	c.609G>A	c.(607-609)gtG>gtA	p.V203V	FRMPD1_ENST00000377765.3_Silent_p.V203V|FRMPD1_ENST00000541302.1_Silent_p.V72V|FRMPD1_ENST00000536622.1_Silent_p.V25V|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	203	FERM.					cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		ACACAACCGTGAAGGTATTAA	0.463000													7	44					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156128250	156128250	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156128250C>T	ENST00000368285.3	+	5	702	c.435C>T	c.(433-435)ttC>ttT	p.F145F	SEMA4A_ENST00000368284.1_Intron|SEMA4A_ENST00000355014.2_Silent_p.F145F|SEMA4A_ENST00000368286.2_Intron|SEMA4A_ENST00000368282.1_Silent_p.F145F|SEMA4A_ENST00000487358.1_3'UTR	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	145	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					GCGGCACCTTCGCCTTCAGCC	0.522000													56	167					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49639110	49639110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49639110C>T	ENST00000334186.4	+	14	1944	c.1595C>T	c.(1594-1596)cCc>cTc	p.P532L	PPFIA3_ENST00000602351.1_Missense_Mutation_p.P532L	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	532						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CACCTGGATCCCTATGTGGCT	0.627000													29	63					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124330411	124330411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124330411C>T	ENST00000338354.3	+	4	251	c.145C>T	c.(145-147)Cca>Tca	p.P49S	DMBT1_ENST00000344338.3_Missense_Mutation_p.P49S|DMBT1_ENST00000368955.3_Missense_Mutation_p.P49S|DMBT1_ENST00000359586.6_Missense_Mutation_p.P49S|DMBT1_ENST00000330163.4_Missense_Mutation_p.P49S|DMBT1_ENST00000368956.2_Missense_Mutation_p.P49S|DMBT1_ENST00000368909.3_Missense_Mutation_p.P49S			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	49					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGCAGGTTCTCCATTTCCCTC	0.552000													60	135					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19566125	19566125	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19566125C>T	ENST00000328041.6	+	6	746	c.549C>T	c.(547-549)atC>atT	p.I183I		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	183						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTGGCACCATCGTGGGCTCAG	0.542000													22	183					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120969581	120969581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120969581G>A	ENST00000273666.6	+	15	1683	c.1412G>A	c.(1411-1413)gGa>gAa	p.G471E	STXBP5L_ENST00000471454.1_Missense_Mutation_p.G471E|STXBP5L_ENST00000492541.1_Missense_Mutation_p.G471E|STXBP5L_ENST00000497029.1_Missense_Mutation_p.G471E|STXBP5L_ENST00000472879.1_Missense_Mutation_p.G471E	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	471					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CATGCAGATGGATCAATAAAA	0.294000													10	34					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52498066	52498066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:52498066C>T	ENST00000261839.7	-	37	4645	c.4484G>A	c.(4483-4485)cGa>cAa	p.R1495Q	RP11-430B1.2_ENST00000560518.1_lincRNA	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1495	Dilute.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		ATGATATATTCGTATAGCCAC	0.303000													17	61					0	0	1	0	0
UBAC2	337867	broad.mit.edu	37	13	99992680	99992680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:99992680C>T	ENST00000376440.2	+	5	1066	c.563C>T	c.(562-564)tCt>tTt	p.S188F	UBAC2_ENST00000460562.1_3'UTR|UBAC2_ENST00000403766.3_Missense_Mutation_p.S223F	NM_177967.3	NP_808882.1	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2	223						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)	10	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCCATCTTCTCTTCTTCAGAA	0.532000													12	109					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100821706	100821706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:100821706G>A	ENST00000358544.2	+	44	8231	c.8120G>A	c.(8119-8121)cGa>cAa	p.R2707Q	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.R2682Q	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2707					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TACAGGGGTCGAACTGCTTCT	0.438000													37	59					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2302930	2302930	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2302930G>A	ENST00000222990.3	-	7	892	c.850C>T	c.(850-852)Ctg>Ttg	p.L284L		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	284					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		GCCTGCTTCAGGGACCCCCAC	0.617000													9	34					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50884459	50884459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50884459G>A	ENST00000313478.7	-	26	4254	c.3973C>T	c.(3973-3975)Ccc>Tcc	p.P1325S	TRPM7_ENST00000560955.1_Missense_Mutation_p.P1325S	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	1325					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTACACTGGGGATCTTTGTCA	0.378000													39	86					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196865582	196865582	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196865582G>A	ENST00000312428.6	-	12	1299	c.1199C>T	c.(1198-1200)cCa>cTa	p.P400L	DNAH7_ENST00000410072.1_Missense_Mutation_p.P400L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	400	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GATGAAACCTGGATGTTCAAA	0.323000													36	95					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71135091	71135091	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:71135091G>A	ENST00000333538.5	+	8	2035	c.1401G>A	c.(1399-1401)ggG>ggA	p.G467G	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	467	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TTGCTTACGGGGAGGTAATTC	0.418000													75	179					0	0	1	0	0
STIM2	57620	broad.mit.edu	37	4	27010620	27010620	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:27010620T>A	ENST00000382009.3	+	11	2037	c.1770T>A	c.(1768-1770)ttT>ttA	p.F590L	STIM2_ENST00000237364.5_Missense_Mutation_p.F582L|STIM2_ENST00000467011.1_Missense_Mutation_p.F495L|STIM2_ENST00000467087.1_Missense_Mutation_p.F495L|STIM2_ENST00000465503.1_Missense_Mutation_p.F503L|STIM2_ENST00000412829.2_Missense_Mutation_p.F582L	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	495					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				TGTCACAATTTCCCGGTAAGT	0.418000													34	83					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162851822	162851822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:162851822C>T	ENST00000360534.3	-	24	2673	c.2113G>A	c.(2113-2115)Gga>Aga	p.G705R	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	705					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	TCTGCTGTTCCATGAATAAGG	0.363000													38	115					0	0	1	0	0
PHLPP1	23239	broad.mit.edu	37	18	60645858	60645858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:60645858C>T	ENST00000400316.4	+	17	4593	c.2812C>T	c.(2812-2814)Ccc>Tcc	p.P938S	PHLPP1_ENST00000262719.5_Missense_Mutation_p.P1450S	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1450					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						CATCTTTCCTCCCTCAGTGAA	0.627000													9	35					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347212	57347212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57347212G>A	ENST00000361249.3	+	5	655	c.559G>A	c.(559-561)Gag>Aag	p.E187K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	187	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGAATGGAGGGAGCTTCGATA	0.453000													40	122					0	0	1	0	0
MFAP5	8076	broad.mit.edu	37	12	8814653	8814653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:8814653G>A	ENST00000359478.2	-	2	235	c.48C>T	c.(46-48)atC>atT	p.I16I	MFAP5_ENST00000433590.2_Silent_p.I16I|MFAP5_ENST00000540087.1_Silent_p.I16I|MFAP5_ENST00000538107.1_5'UTR|MFAP5_ENST00000535336.1_Silent_p.I16I|MFAP5_ENST00000543369.1_Silent_p.I16I|MFAP5_ENST00000396549.2_Silent_p.I16I	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	16						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					CAGAGGTGATGATGAATGCAG	0.512000													10	23					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7571684	7571684	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7571684C>T	ENST00000379802.3	+	14	2111	c.1770C>T	c.(1768-1770)ttC>ttT	p.F590F	DSP_ENST00000418664.2_Silent_p.F590F	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	590	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACCAAGAGTTCATCAGAAATA	0.458000													30	266					0	0	1	0	0
ELANE	1991	broad.mit.edu	37	19	856138	856138	+	Missense_Mutation	SNP	C	C	T	rs143579306	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:856138C>T	ENST00000590230.1	+	6	919	c.778C>T	c.(778-780)Ccg>Tcg	p.P260S	ELANE_ENST00000263621.1_Missense_Mutation_p.P260S			P08246	ELNE_HUMAN	elastase, neutrophil expressed	260					cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(1)|lung(4)|pancreas(1)	13					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CCCCCGGGACCCGGACCCGGC	0.612000													51	186					0	0	1	0	0
DDHD2	23259	broad.mit.edu	37	8	38110573	38110573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:38110573C>T	ENST00000397166.2	+	15	2344	c.1819C>T	c.(1819-1821)Cct>Tct	p.P607S	DDHD2_ENST00000520272.2_Missense_Mutation_p.P607S|DDHD2_ENST00000529845.1_Missense_Mutation_p.P58S|DDHD2_ENST00000517385.1_Missense_Mutation_p.P226S	NM_015214.2	NP_056029.2	O94830	DDHD2_HUMAN	DDHD domain containing 2	607	DDHD.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)|urinary_tract(2)	28	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			AGCTCCATACCCTGCCTTACA	0.483000													7	65					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40301883	40301883	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40301883C>T	ENST00000263791.5	+	26	3688	c.3645C>T	c.(3643-3645)atC>atT	p.I1215I	EIF2AK4_ENST00000382727.2_Silent_p.I1187I	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1215	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		ACTGTGGGATCCCAGAAGATA	0.313000													48	89					0	0	1	0	0
PCBP2	5094	broad.mit.edu	37	12	53856349	53856349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53856349C>T	ENST00000603815.1	+	8	939	c.589C>T	c.(589-591)Cag>Tag	p.Q197*	PCBP2_ENST00000359462.5_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000552296.2_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000548933.1_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000549863.1_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000546463.1_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000455667.3_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000552819.1_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000437231.1_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000359282.5_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000447282.1_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000541275.1_Nonsense_Mutation_p.Q193*|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000439930.3_Nonsense_Mutation_p.Q197*	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	197					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						TGCAGGTGGTCAGGTAAGAAA	0.512000													11	57					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760700	92760700	+	Missense_Mutation	SNP	C	C	T	rs147406199		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:92760700C>T	ENST00000318238.4	-	5	5801	c.4585G>A	c.(4585-4587)Gct>Act	p.A1529T	SAMD9L_ENST00000411955.1_Missense_Mutation_p.A1529T|SAMD9L_ENST00000437805.1_Missense_Mutation_p.A1529T	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1529										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGCCTTCAGCCTGACCAGTT	0.398000													22	96					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049324	36049324	+	Silent	SNP	G	G	A	rs148290056	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36049324G>A	ENST00000282507.3	-	4	611	c.510C>T	c.(508-510)ttC>ttT	p.F170F	UGT3A2_ENST00000513300.1_Silent_p.F136F|UGT3A2_ENST00000545528.1_Intron|UGT3A2_ENST00000504954.1_Intron	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	170						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCAAAGAGCCGAATGAAGTGG	0.453000													33	63					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85973846	85973846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85973846C>T	ENST00000372117.3	+	17	2152	c.2049C>T	c.(2047-2049)tcC>tcT	p.S683S	CDHR1_ENST00000332904.3_Intron|CDHR1_ENST00000440770.2_Silent_p.S387S	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	683	Cadherin 6.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						AGACCCTCTCCCGGAGCCCCA	0.582000													41	89					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124193559	124193559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124193559G>A	ENST00000360013.3	+	26	4202	c.4075G>A	c.(4075-4077)Gga>Aga	p.G1359R	KALRN_ENST00000240874.3_Missense_Mutation_p.G1359R|KALRN_ENST00000460856.1_Missense_Mutation_p.G1350R	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1359	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGAGGATGTGGGACACTGCTT	0.517000													18	53					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224437993	224437993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:224437993G>A	ENST00000281701.6	-	19	2469	c.2210C>T	c.(2209-2211)cCg>cTg	p.P737L	NVL_ENST00000340871.4_Missense_Mutation_p.P548L|NVL_ENST00000361463.3_3'UTR|NVL_ENST00000469075.1_Missense_Mutation_p.P646L|NVL_ENST00000482491.1_Missense_Mutation_p.P461L|NVL_ENST00000391875.2_Missense_Mutation_p.P631L	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	737						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		CAGGCGGCCCGGGCGCAGGAT	0.393000													26	74					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15448386	15448386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:15448386G>A	ENST00000281513.5	-	40	4776	c.4751C>T	c.(4750-4752)gCc>gTc	p.A1584V	NBAS_ENST00000441750.1_Missense_Mutation_p.A1464V	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1584										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						GGCCAATCGGGCATAGATCTG	0.473000													16	42					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79051844	79051844	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79051844G>A	ENST00000388820.4	-	24	5190	c.4980C>T	c.(4978-4980)atC>atT	p.I1660I		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1660	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						ACTGGGTGCGGATGGTGGGCA	0.721000													4	11					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15375521	15375521	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15375521G>A	ENST00000263377.2	-	6	1127	c.906C>T	c.(904-906)ccC>ccT	p.P302P	BRD4_ENST00000360016.5_Silent_p.P302P|BRD4_ENST00000371835.4_Silent_p.P302P	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	302					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GCTCGTGAATGGGGTCAATGG	0.622000			T	C15orf55	lethal midline carcinoma of young people						OREG0025319	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	180					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882168	228882168	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228882168C>T	ENST00000392056.3	-	7	3448	c.3402G>A	c.(3400-3402)gtG>gtA	p.V1134V	SPHKAP_ENST00000344657.5_Silent_p.V1134V	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1134						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CCATCTGGTTCACCATGAACC	0.527000													17	36					0	0	1	0	0
FKBP2	2286	broad.mit.edu	37	11	64010707	64010707	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64010707C>T	ENST00000394540.3	+	3	678	c.208C>T	c.(208-210)Ctg>Ttg	p.L70L	FKBP2_ENST00000449942.2_Silent_p.L70L|FKBP2_ENST00000309366.4_Silent_p.L70L	NM_057092.2	NP_476433.1	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa	70	PPIase FKBP-type.				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			endometrium(2)|lung(3)	5						TGACAGCAGCCTGCCCCAGAA	0.617000													7	56					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17757553	17757553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17757553G>A	ENST00000379472.3	+	1	34	c.4G>A	c.(4-6)Ggc>Agc	p.G2S	KCNC1_ENST00000265969.6_Missense_Mutation_p.G2S	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	2						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CGCCGCGATGGGCCAAGGGGA	0.761000													7	8					0	0	1	0	0
NUP62CL	54830	broad.mit.edu	37	X	106396730	106396730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:106396730G>A	ENST00000372466.4	-	6	600	c.349C>T	c.(349-351)Cgt>Tgt	p.R117C	NUP62CL_ENST00000372461.3_Silent_p.F66F	NM_017681.2	NP_060151.2	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	117					protein transport	nuclear pore	structural constituent of nuclear pore			lung(4)	4						TGTAAAATACGAATCTATAAA	0.259000													18	13					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613628	179613628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179613628C>T	ENST00000360870.5	-	46	13721	c.13499G>A	c.(13498-13500)aGa>aAa	p.R4500K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	630	Ig-like 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTGATTCTCTTTGCTTTAA	0.318000													37	52					0	0	1	0	0
TNNT1	7138	broad.mit.edu	37	19	55652277	55652277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55652277C>T	ENST00000588981.1	-	9	565	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K	TNNT1_ENST00000291901.8_Missense_Mutation_p.E121K|TNNT1_ENST00000536926.1_Missense_Mutation_p.E110K|TNNT1_ENST00000587758.1_Missense_Mutation_p.E110K|TNNT1_ENST00000592920.1_5'UTR|TNNT1_ENST00000585321.2_Missense_Mutation_p.E51K|TNNT1_ENST00000588426.1_Missense_Mutation_p.E18K|TNNT1_ENST00000356783.5_Missense_Mutation_p.E110K|TNNT1_ENST00000587465.2_Missense_Mutation_p.E51K	NM_003283.4	NP_003274.3	P13805	TNNT1_HUMAN	troponin T type 1 (skeletal, slow)	121					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CGTTCGCGTTCCTTCTCAGTT	0.562000													22	65					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124360020	124360020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124360020C>T	ENST00000409039.3	+	46	7852	c.7827C>T	c.(7825-7827)atC>atT	p.I2609I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2609	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATTCCTCCATCCTGAAAGGCC	0.438000													28	84					0	0	1	0	0
MAPK15	225689	broad.mit.edu	37	8	144802954	144802954	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144802954C>T	ENST00000338033.4	+	9	980	c.861C>T	c.(859-861)ttC>ttT	p.F287F		NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	287	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding	p.F306F(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCCTGGTGTTCGCCCCGGACA	0.672000													5	31					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6749241	6749241	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6749241C>T	ENST00000229243.2	-	8	1503	c.1410G>A	c.(1408-1410)ggG>ggA	p.G470G	ACRBP_ENST00000542357.1_5'UTR|ACRBP_ENST00000414226.2_Silent_p.G437G	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	470						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						TAGGGAAATCCCCATCCTGGA	0.542000													9	34					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124045712	124045712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124045712C>T	ENST00000368994.2	+	5	588	c.337C>T	c.(337-339)Ctg>Ttg	p.L113L	BTBD16_ENST00000260723.4_Silent_p.L112L			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	112										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CCTGAAAGCCCTGGCGCAGGG	0.602000													52	115					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179728597	179728597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:179728597G>A	ENST00000253778.8	-	19	2185	c.2016C>T	c.(2014-2016)ccC>ccT	p.P672P		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	672	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CCAGATTTCTGGGGAAGTCAA	0.453000													22	81					0	0	1	0	0
DDX59	83479	broad.mit.edu	37	1	200635747	200635747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:200635747G>A	ENST00000447706.2	-	2	273	c.122C>T	c.(121-123)cCc>cTc	p.P41L	DDX59_ENST00000331314.6_Missense_Mutation_p.P41L|DDX59_ENST00000367348.3_Missense_Mutation_p.P41L			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	41						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						AGCATCAACGGGAACATCTCT	0.468000													50	139					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791484	95791484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95791484G>A	ENST00000260766.3	+	2	1315	c.681G>A	c.(679-681)aaG>aaA	p.K227K	PLCE1_ENST00000371380.2_Silent_p.K227K	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	227					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				AGAAGCAAAAGAAAAACTATG	0.388000													15	57					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733541	152733541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152733541G>A	ENST00000368773.1	+	2	1535	c.1477G>A	c.(1477-1479)Gag>Aag	p.E493K	KPRP_ENST00000606109.1_Missense_Mutation_p.E493K	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	493	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCCTGCAGGGAGACTTGGCG	0.652000													35	74					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27197484	27197484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:27197484C>T	ENST00000380036.4	+	12	2238	c.1796C>T	c.(1795-1797)tCg>tTg	p.S599L	TEK_ENST00000519097.1_Missense_Mutation_p.S452L|TEK_ENST00000406359.4_Missense_Mutation_p.S556L	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	599	Fibronectin type-III 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AACTTGACTTCGGTGCTACTT	0.463000													50	85					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90872781	90872781	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:90872781T>A	ENST00000394980.1	+	8	3463	c.3144T>A	c.(3142-3144)caT>caA	p.H1048Q	MMRN1_ENST00000264790.2_Missense_Mutation_p.H1048Q|MMRN1_ENST00000508372.1_Missense_Mutation_p.H790Q|MMRN1_ENST00000394981.1_Missense_Mutation_p.H351Q			Q13201	MMRN1_HUMAN	multimerin 1	1048	EGF-like.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GTAGTCGGCATCCGTGCCAAA	0.433000													20	56					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145770733	145770733	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145770733G>A	ENST00000276826.5	-	5	2622	c.2421C>T	c.(2419-2421)ctC>ctT	p.L807L	ARHGAP39_ENST00000377307.2_Silent_p.L807L|ARHGAP39_ENST00000540274.1_Silent_p.L807L|ARHGAP39_ENST00000528810.1_5'UTR			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	807	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						AGATGGCCATGAGCTCCCAGC	0.637000													9	45					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64627777	64627777	+	Silent	SNP	G	G	A	rs148805183		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64627777G>A	ENST00000320631.3	-	3	788	c.534C>T	c.(532-534)ttC>ttT	p.F178F	EHD1_ENST00000359393.2_Silent_p.F178F	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	178					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						CACGCTCCGCGAACCACTCCA	0.587000													19	34					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49228277	49228277	+	Silent	SNP	G	G	A	rs143841455		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49228277G>A	ENST00000308025.3	-	12	1465	c.1386C>T	c.(1384-1386)atC>atT	p.I462I		NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	462	Helicase ATP-binding.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						CTGACTCTTCGATCCTGTGGT	0.527000													34	53					0	0	1	0	0
SPP1	6696	broad.mit.edu	37	4	88903860	88903860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:88903860G>A	ENST00000237623.7	+	6	863	c.715G>A	c.(715-717)Gag>Aag	p.E239K	SPP1_ENST00000509659.1_3'UTR|SPP1_ENST00000360804.4_Missense_Mutation_p.E226K|SPP1_ENST00000395080.3_Missense_Mutation_p.E253K	NM_000582.2	NP_000573.1	P10451	OSTP_HUMAN	secreted phosphoprotein 1	253					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(1)	13		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		AGCCAATGATGAGAGCAATGA	0.468000													31	102					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13395998	13395998	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13395998G>T	ENST00000360228.5	-	21	3575	c.3576C>A	c.(3574-3576)gaC>gaA	p.D1192E	CACNA1A_ENST00000573710.2_Missense_Mutation_p.D1193E	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1193					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TTGGCAGTGGGTCTGGGTTGG	0.537000													18	59					3.32936e-07	3.33782e-07	1	1	0
CR1	1378	broad.mit.edu	37	1	207758014	207758014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207758014C>T	ENST00000367049.4	+	33	5323	c.5323C>T	c.(5323-5325)Cca>Tca	p.P1775S	CR1_ENST00000400960.2_Missense_Mutation_p.P1325S|CR1_ENST00000367052.1_Missense_Mutation_p.P1325S|CR1_ENST00000367053.1_Missense_Mutation_p.P1325S|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367051.1_Missense_Mutation_p.P1325S|RP11-78B10.2_ENST00000597497.1_RNA	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1325	Sushi 28.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TCCAAATCCTCCAGCTATCCT	0.388000													31	117					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274034	10274034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10274034G>A	ENST00000396573.2	-	3	544	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	GRIN2A_ENST00000404927.2_Missense_Mutation_p.P79S|GRIN2A_ENST00000562109.1_Missense_Mutation_p.P79S|GRIN2A_ENST00000330684.3_Missense_Mutation_p.P79S|GRIN2A_ENST00000396575.2_Missense_Mutation_p.P79S	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	79					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGCTCTTGGGGTCGGTGCGG	0.662000													26	109					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47913525	47913525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:47913525G>A	ENST00000426837.2	-	13	5910	c.5823C>T	c.(5821-5823)gcC>gcT	p.A1941A	MAP4_ENST00000264724.11_Silent_p.A531A|MAP4_ENST00000383737.4_Silent_p.A524A|MAP4_ENST00000441748.2_5'UTR|MAP4_ENST00000360240.6_Silent_p.A796A|MAP4_ENST00000462206.1_5'UTR|MAP4_ENST00000420772.2_Silent_p.A547A|MAP4_ENST00000395734.3_Silent_p.A796A			P27816	MAP4_HUMAN	microtubule-associated protein 4	796					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CAGATCTGGAGGCTGGGGCAG	0.577000													71	205					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42439523	42439523	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42439523C>T	ENST00000397272.3	-	13	1315	c.1224G>A	c.(1222-1224)agG>agA	p.R408R	PLA2G4F_ENST00000382396.4_Silent_p.R406R	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	406	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		AGGCTGGGTCCCTGTAGAGTG	0.632000													17	35					0	0	1	0	0
FAM178A	55719	broad.mit.edu	37	10	102676652	102676652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:102676652C>T	ENST00000238961.3	+	3	658	c.510C>T	c.(508-510)tcC>tcT	p.S170S	FAM178A_ENST00000370269.3_Silent_p.S170S|FAM178A_ENST00000370271.3_Silent_p.S170S	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	170																	AACATCGATCCCCAGAGAGAA	0.388000													22	53					0	0	1	0	0
DCN	1634	broad.mit.edu	37	12	91539941	91539941	+	Missense_Mutation	SNP	G	G	A	rs138244851		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91539941G>A	ENST00000052754.5	-	8	1475	c.974C>T	c.(973-975)tCg>tTg	p.S325L	DCN_ENST00000420120.2_Missense_Mutation_p.S216L|DCN_ENST00000228329.5_Missense_Mutation_p.S216L|DCN_ENST00000441303.2_Missense_Mutation_p.S138L|DCN_ENST00000547568.2_Missense_Mutation_p.S178L|DCN_ENST00000552962.1_Missense_Mutation_p.S325L|DCN_ENST00000393155.1_Missense_Mutation_p.S325L|DCN_ENST00000425043.1_Missense_Mutation_p.S178L|DCN_ENST00000303320.3_Missense_Mutation_p.S138L	NM_001920.3	NP_001911.1	P07585	PGS2_HUMAN	decorin	325					organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						ACTCACACCCGAATAAGAAGC	0.463000													46	89					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156642565	156642565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156642565G>A	ENST00000368223.3	-	4	1547	c.1415C>T	c.(1414-1416)cCt>cTt	p.P472L		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	472	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGAGTGGTCAGGGCTGAGGGG	0.612000													20	180					0	0	1	0	0
ZNF80	7634	broad.mit.edu	37	3	113955468	113955468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113955468G>A	ENST00000482457.2	-	1	957	c.454C>T	c.(454-456)Cgt>Tgt	p.R152C		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	152						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				TGGGTCACACGATGCTGGATG	0.488000													25	84					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145770958	145770958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145770958G>A	ENST00000276826.5	-	5	2397	c.2196C>T	c.(2194-2196)atC>atT	p.I732I	ARHGAP39_ENST00000377307.2_Silent_p.I732I|ARHGAP39_ENST00000540274.1_Silent_p.I732I|ARHGAP39_ENST00000528810.1_5'UTR			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	732	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CGCTTGTCACGATCATGGGCT	0.612000													13	41					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93839179	93839179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93839179G>A	ENST00000315765.9	+	17	2936	c.2928G>A	c.(2926-2928)ggG>ggA	p.G976G		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	976	Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AGATTTTTGGGAATCTCCATG	0.333000													15	37					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127549481	127549481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127549481G>A	ENST00000373580.3	+	2	318	c.318G>A	c.(316-318)atG>atA	p.M106I		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	106										endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						AGTGGAAGATGGAGAAACTCA	0.587000													22	46					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39202753	39202753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:39202753C>T	ENST00000351578.6	-	2	500	c.310G>A	c.(310-312)Gag>Aag	p.E104K	FYB_ENST00000540520.1_Missense_Mutation_p.E114K|FYB_ENST00000515010.1_Missense_Mutation_p.E104K|FYB_ENST00000512982.1_Missense_Mutation_p.E104K|FYB_ENST00000505428.1_Missense_Mutation_p.E104K	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	104					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			ACTTTCGCCTCGGGGTCTCTG	0.542000													14	35					0	0	1	0	0
GK5	256356	broad.mit.edu	37	3	141944198	141944198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141944198G>A	ENST00000392993.2	-	1	251	c.100C>T	c.(100-102)Cac>Tac	p.H34Y	GK5_ENST00000544571.1_Missense_Mutation_p.H34Y|GK5_ENST00000466685.3_5'UTR	NM_001039547.2	NP_001034636.1	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	34					glycerol metabolic process		ATP binding|glycerol kinase activity			kidney(1)|large_intestine(1)|lung(7)|urinary_tract(1)	10						TCATAGACGTGGCAGCGGATC	0.701000													5	6					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145111880	145111880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145111880C>T	ENST00000426825.1	-	12	1758	c.1677G>A	c.(1675-1677)gtG>gtA	p.V559V	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	559							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GCAGAGCATCCACACACTGCT	0.652000													3	7					0	0	1	0	0
MRPL9	65005	broad.mit.edu	37	1	151734888	151734888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151734888G>A	ENST00000368830.3	-	3	483	c.399C>T	c.(397-399)tcC>tcT	p.S133S	MRPL9_ENST00000467306.1_5'UTR|MRPL9_ENST00000368829.3_Silent_p.S133S	NM_031420.2	NP_113608.1	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9	133					translation	mitochondrial ribosome	structural constituent of ribosome			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGTTTTCAGGGGATGCATATA	0.468000													19	147					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92401568	92401568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:92401568G>A	ENST00000276609.3	+	16	1917	c.1678G>A	c.(1678-1680)Gaa>Aaa	p.E560K	SLC26A7_ENST00000523719.1_Missense_Mutation_p.E560K|SLC26A7_ENST00000309536.2_Missense_Mutation_p.E560K|SLC26A7_ENST00000520249.1_3'UTR	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	560	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TCCTACAGAAGAAGCTTCACA	0.438000													86	173					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57428860	57428860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57428860G>A	ENST00000306120.3	+	1	350	c.350G>A	c.(349-351)aGg>aAg	p.R117K	GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371075.3_Intron|GNAS_ENST00000371099.2_Silent_p.Q180Q|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371100.4_Silent_p.Q180Q|GNAS_ENST00000371102.4_Silent_p.Q180Q|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000603534.1_Intron			P63092	GNAS2_HUMAN	GNAS complex locus	292					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TTCTCTTACAGGTCCCAGACC	0.632000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			8	13					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43250678	43250678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43250678G>A	ENST00000259750.4	+	14	2283	c.2200G>A	c.(2200-2202)Gaa>Aaa	p.E734K		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	734	Glu-rich.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TGGGAaggaggaagaggagga	0.577000													22	31					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20073517	20073517	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20073517C>T	ENST00000351989.3	+	2	460	c.31C>T	c.(31-33)Ccg>Tcg	p.P11S	DGCR8_ENST00000383024.2_Missense_Mutation_p.P11S|DGCR8_ENST00000407755.1_Missense_Mutation_p.P11S	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	11	Necessary for interaction with NCL.|Necessary for nuclear localization and retention.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					CTCTCCGCTCCCGTGTGGGCC	0.557000													60	112					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27517295	27517295	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27517295G>T	ENST00000356183.4	-	10	1710	c.1695C>A	c.(1693-1695)tcC>tcA	p.S565S	GTF3C1_ENST00000561623.1_Silent_p.S565S	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	565						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGGAGACAAAGGACACGTTGG	0.587000													50	82					1.67211e-32	1.68365e-32	1	1	0
TPRX1	284355	broad.mit.edu	37	19	48305051	48305051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48305051C>T	ENST00000535759.1	-	4	1507	c.1508G>A	c.(1507-1509)aGg>aAg	p.R503K	TPRX1_ENST00000543508.1_Missense_Mutation_p.R396K|TPRX1_ENST00000322175.3_Missense_Mutation_p.R406K			Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox 1	406						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|skin(1)	18		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		CAGTAATAACCTGGGGCCTGA	0.517000													9	104					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150877775	150877775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:150877775C>T	ENST00000474524.1	+	7	1032	c.994C>T	c.(994-996)Ccc>Tcc	p.P332S	MED12L_ENST00000309237.4_Missense_Mutation_p.P332S|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000422248.2_Missense_Mutation_p.P332S	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	332					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TATCGGGGCCCCCAGCCCTGG	0.607000													25	213					0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123664511	123664511	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123664511C>T	ENST00000542236.1	+	3	1845	c.1464C>T	c.(1462-1464)atC>atT	p.I488I	BBS12_ENST00000314218.3_Silent_p.I488I	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	488					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						ACAACAGAATCGCAATCTTAT	0.438000									Bardet-Biedl syndrome				15	88					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100147828	100147828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:100147828C>T	ENST00000231461.5	-	5	1113	c.803G>A	c.(802-804)tGg>tAg	p.W268*		NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	268					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		GTTGGTCAGCCAGTAACTGGA	0.363000													19	64					0	0	1	0	0
TMC8	147138	broad.mit.edu	37	17	76128477	76128477	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76128477C>T	ENST00000318430.5	+	4	710	c.336C>T	c.(334-336)ttC>ttT	p.F112F	TMC6_ENST00000322914.3_5'UTR|TMC8_ENST00000589691.1_5'UTR	NM_152468.4	NP_689681.2	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	112						endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ACTTCACCTTCCTCCGCTTCC	0.682000													7	18					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135431686	135431686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135431686C>T	ENST00000394143.1	+	6	6112	c.5821C>T	c.(5821-5823)Cct>Tct	p.P1941S	GPR112_ENST00000370652.1_Missense_Mutation_p.P1941S|GPR112_ENST00000394141.1_Missense_Mutation_p.P1736S|GPR112_ENST00000412101.1_Missense_Mutation_p.P1736S|GPR112_ENST00000287534.4_Missense_Mutation_p.P1878S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1941					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GTCATCAATTCCTATGTCAGG	0.433000													37	38					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294372	25294372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25294372G>A	ENST00000400358.4	+	19	2513	c.2456G>A	c.(2455-2457)aGc>aAc	p.S819N	SGSM1_ENST00000400359.4_Missense_Mutation_p.S874N	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	874	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						GGCTGGAGGAGCAGCGAGACA	0.592000													11	92					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3081303	3081303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3081303C>T	ENST00000520002.1	-	29	4990	c.4435G>A	c.(4435-4437)Gac>Aac	p.D1479N	CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000542608.1_Missense_Mutation_p.D1478N|CSMD1_ENST00000400186.3_Missense_Mutation_p.D1479N|CSMD1_ENST00000602557.1_Missense_Mutation_p.D1479N|CSMD1_ENST00000537824.1_Missense_Mutation_p.D1478N|CSMD1_ENST00000602723.1_Missense_Mutation_p.D1479N|CSMD1_ENST00000539096.1_Missense_Mutation_p.D1478N			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1479	CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACTCTCCAGTCACATTCCTTC	0.463000													24	60					0	0	1	0	0
KRT19	3880	broad.mit.edu	37	17	39680673	39680673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39680673G>A	ENST00000361566.3	-	4	840	c.780C>T	c.(778-780)gcC>gcT	p.A260A		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				GGTTCTGCTCGGCCATGACCT	0.602000													10	84					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229058	21229058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21229058G>A	ENST00000233242.1	-	26	10809	c.10682C>T	c.(10681-10683)tCc>tTc	p.S3561F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3561					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTCCCAGAGGGAATATATGCG	0.458000													22	58					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130831552	130831552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130831552G>A	ENST00000245255.3	+	6	870	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	200					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TTTAACAAATGAACTTCCACC	0.353000													8	66					0	0	1	0	0
PQLC1	80148	broad.mit.edu	37	18	77679198	77679198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:77679198G>A	ENST00000397778.2	-	5	776	c.594C>T	c.(592-594)tcC>tcT	p.S198S	PQLC1_ENST00000590381.1_Intron|PQLC1_ENST00000409073.1_Silent_p.S115S|PQLC1_ENST00000357575.4_Silent_p.S180S	NM_025078.4	NP_079354.2	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1	198	PQ-loop 2.					integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		TGCCCTCCGTGGACTGGTGGC	0.612000													12	39					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32913746	32913746	+	Missense_Mutation	SNP	C	C	T	rs80358749		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32913746C>T	ENST00000544455.1	+	11	5481	c.5254C>T	c.(5254-5256)Cat>Tat	p.H1752Y	BRCA2_ENST00000380152.3_Missense_Mutation_p.H1752Y	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1752					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CTATTCCTACCATTCTGATGA	0.308000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			25	53					0	0	1	0	0
COPS7B	64708	broad.mit.edu	37	2	232672238	232672238	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:232672238C>T	ENST00000373608.3	+	8	838	c.731C>T	c.(730-732)cCt>cTt	p.P244L	COPS7B_ENST00000409295.1_Silent_p.S192S|COPS7B_ENST00000409091.1_Silent_p.S119S|COPS7B_ENST00000410017.1_Missense_Mutation_p.P249L|COPS7B_ENST00000350033.3_Silent_p.S226S|COPS7B_ENST00000410024.1_Silent_p.S226S			Q9H9Q2	CSN7B_HUMAN	COP9 signalosome subunit 7B	0					cullin deneddylation	cytoplasm|signalosome				large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)	8		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;1.36e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00136)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CCGCATCCTCCTCGGCTCAGG	0.547000													13	37					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42581868	42581868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:42581868C>T	ENST00000381668.5	-	11	1193	c.962G>A	c.(961-963)cGa>cAa	p.R321Q	ATP8A1_ENST00000264449.10_Missense_Mutation_p.R321Q	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	321					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity	p.R321Q(1)		NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	AGAATGCCTTCGATTCCAAAT	0.338000													14	52					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62496099	62496099	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62496099G>A	ENST00000225792.5	-	13	2188	c.1787C>T	c.(1786-1788)cCt>cTt	p.P596L	DDX5_ENST00000578804.1_Missense_Mutation_p.P596L|DDX5_ENST00000450599.2_Missense_Mutation_p.P517L	NM_004396.3	NP_004387.1	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 5	596					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			TGCAGTAGCAGGATATGCATA	0.388000			T	ETV4	prostate								8	66					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93098092	93098092	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:93098092A>G	ENST00000359558.2	-	8	809	c.510T>C	c.(508-510)gcT>gcC	p.A170A	CALCR_ENST00000394441.1_Silent_p.A152A|CALCR_ENST00000421592.1_Silent_p.A152A|CALCR_ENST00000360249.4_Silent_p.A152A|CALCR_ENST00000426151.1_Silent_p.A152A	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	152					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GACCCACAATAGCCAAATAGT	0.343000													15	54					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209790845	209790845	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:209790845G>A	ENST00000391911.1	-	20	3527	c.3138C>T	c.(3136-3138)ctC>ctT	p.L1046L	LAMB3_ENST00000356082.4_Silent_p.L1046L|LAMB3_ENST00000367030.3_Silent_p.L1046L	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1046	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CTTGGTGGCGGAGCTCCTCCA	0.607000													29	89					0	0	1	0	0
TSPAN32	10077	broad.mit.edu	37	11	2335756	2335756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2335756G>A	ENST00000182290.4	+	6	635	c.498G>A	c.(496-498)ggG>ggA	p.G166G	TSPAN32_ENST00000381121.3_Silent_p.G166G|TSPAN32_ENST00000451520.2_Silent_p.G155G|TSPAN32_ENST00000483227.1_3'UTR	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	166					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GCCGTCTGGGGAGCACAGAGG	0.642000													9	13					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35923043	35923043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35923043C>T	ENST00000490799.1	-	17	2471	c.2118G>A	c.(2116-2118)agG>agA	p.R706R	SLC26A8_ENST00000394602.2_Silent_p.R601R|SLC26A8_ENST00000355574.2_Silent_p.R706R	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	706	Interaction with RACGAP1.|STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						TGAGTGATCTCCTCCCCTGGC	0.517000													29	55					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189022399	189022399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189022399C>T	ENST00000512729.1	-	3	515	c.141G>A	c.(139-141)gaG>gaA	p.E47E	TRIML2_ENST00000536972.1_Silent_p.E97E|TRIML2_ENST00000326754.3_Silent_p.E47E	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	47							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AATTTTGTTCCTCTTCCTTCC	0.348000													16	46					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004631	75004631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:75004631C>T	ENST00000373359.2	-	1	448	c.256G>A	c.(256-258)Gac>Aac	p.D86N		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	86										autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCTAGAGGGTCATGGACCCTG	0.547000													18	24					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227946862	227946862	+	Silent	SNP	C	C	T	rs137880920	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:227946862C>T	ENST00000396625.3	-	23	1872	c.1665G>A	c.(1663-1665)gcG>gcA	p.A555A	COL4A4_ENST00000329662.7_Silent_p.A555A	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	555	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGTCACCCTTCGCCCCTTTGT	0.418000													98	102					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43814503	43814503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43814503G>A	ENST00000382031.1	+	5	1577	c.1546G>A	c.(1546-1548)Gag>Aag	p.E516K	MAP1A_ENST00000399453.1_Missense_Mutation_p.E278K|MAP1A_ENST00000300231.5_Missense_Mutation_p.E278K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	278	9 X 3 AA repeats of K-K-[DE].					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CAAGATCTTGGAGGGCCTAGA	0.547000													14	61					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19468081	19468081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19468081C>T	ENST00000219821.5	+	1	310	c.53C>T	c.(52-54)tCc>tTc	p.S18F	TMC5_ENST00000396229.2_Intron|TMC5_ENST00000542583.2_Intron|TMC5_ENST00000541464.1_Intron|TMC5_ENST00000381414.4_Intron|TMC5_ENST00000561503.1_Intron|TMC5_ENST00000564959.1_Intron	NM_024780.4	NP_079056.2	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	0						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GAGAATGTTTCCTCTGGGGTC	0.468000													29	56					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772917	140772917	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140772917C>T	ENST00000398604.2	+	1	537	c.537C>T	c.(535-537)tcC>tcT	p.S179S	PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACTTCTCCCTGGACGTGC	0.607000													26	71					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10387188	10387188	+	Silent	SNP	G	G	A	rs111706887		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10387188G>A	ENST00000397077.1	-	17	3023	c.2448C>T	c.(2446-2448)atC>atT	p.I816I	ATP2B2_ENST00000383800.4_Silent_p.I816I|ATP2B2_ENST00000360273.2_Silent_p.I861I|ATP2B2_ENST00000352432.4_Silent_p.I861I|ATP2B2_ENST00000343816.4_Silent_p.I847I			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	861					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CTGCCTTGACGATGCTGCTGA	0.577000													27	60					0	0	1	0	0
EXOSC2	23404	broad.mit.edu	37	9	133576301	133576301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133576301G>A	ENST00000372358.5	+	6	545	c.474G>A	c.(472-474)acG>acA	p.T158T	EXOSC2_ENST00000372352.3_Silent_p.T158T|EXOSC2_ENST00000372351.3_Silent_p.T128T|EXOSC2_ENST00000467138.1_3'UTR|EXOSC2_ENST00000546165.1_Intron			Q13868	EXOS2_HUMAN	exosome component 2	158	S1 motif.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|positive regulation of cell growth|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|7S RNA binding|protein binding			breast(1)|endometrium(1)|large_intestine(3)|ovary(1)	6		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(13;0.0588)		OV - Ovarian serous cystadenocarcinoma(145;0.000324)		CTTTGCACACGAGGAGCCTGA	0.502000											OREG0019548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	56					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39064597	39064597	+	Silent	SNP	G	G	A	rs138598029	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:39064597G>A	ENST00000331366.5	-	19	1536	c.1440C>T	c.(1438-1440)gtC>gtT	p.V480V	CPNE8_ENST00000538596.2_Silent_p.V149V|CPNE8_ENST00000546603.1_5'UTR|CPNE8_ENST00000360449.3_Silent_p.V468V	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	480	VWFA.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CATCCAATTCGACCATTGCTT	0.338000													17	45					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3850757	3850757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3850757G>A	ENST00000309890.7	-	8	1173	c.1023C>T	c.(1021-1023)acC>acT	p.T341T	ATP2A3_ENST00000352011.3_Silent_p.T341T|ATP2A3_ENST00000359983.3_Silent_p.T341T|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397041.3_Silent_p.T341T|ATP2A3_ENST00000397035.3_Silent_p.T341T|ATP2A3_ENST00000397043.3_Silent_p.T341T	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	341					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		TGCAGCCCAGGGTCTCCACGG	0.647000													33	43					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165947774	165947774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165947774C>T	ENST00000360093.3	-	28	5380	c.4889G>A	c.(4888-4890)cGa>cAa	p.R1630Q	AC013463.2_ENST00000431341.1_RNA|SCN3A_ENST00000540861.1_Missense_Mutation_p.R113Q|SCN3A_ENST00000283254.7_Missense_Mutation_p.R1630Q|SCN3A_ENST00000409101.3_Missense_Mutation_p.R1581Q	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1630						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ACGTAGGATTCGGCCAATCCT	0.478000													52	113					0	0	1	0	0
ZNF702P	79986	broad.mit.edu	37	19	53473805	53473805	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:53473805G>A	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							AGATGTGAATGAAAGCTTGAT	0.388000													38	104					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26822398	26822398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26822398G>A	ENST00000376236.4	+	9	1299	c.844G>A	c.(844-846)Gaa>Aaa	p.E282K		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	282					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						AGGAAAAAAAGAAAGCAAGGA	0.343000													9	47					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37319369	37319369	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37319369C>T	ENST00000262825.5	+	3	377	c.160C>T	c.(160-162)Cag>Tag	p.Q54*	CSF2RB_ENST00000406230.1_Nonsense_Mutation_p.Q54*|CSF2RB_ENST00000403662.3_Nonsense_Mutation_p.Q54*	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	54					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CCAGGATGCCCAGCGGCTCGT	0.637000													11	41					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77677753	77677753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77677753C>T	ENST00000296043.6	+	8	5814	c.4861C>T	c.(4861-4863)Cac>Tac	p.H1621Y		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1621					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			CATGAGCGTTCACGCCCAACT	0.537000													34	66					0	0	1	0	0
HOXA9	3205	broad.mit.edu	37	7	27204563	27204563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:27204563C>T	ENST00000343483.6	-	1	586	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	HOXA9_ENST00000497089.1_Intron|RP1-170O19.20_ENST00000470747.4_Missense_Mutation_p.E12K|RP1-170O19.20_ENST00000465941.1_Intron|HOXA9_ENST00000396345.1_3'UTR	NM_152739.3	NP_689952.1	P31269	HXA9_HUMAN	homeobox A9	172							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|lung(5)|prostate(1)	8						AAGGCGCCTTCGCTGGGTTGT	0.552000			T	"""NUP98, MSI2"""	AML*								18	57					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541451	40541451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40541451G>A	ENST00000434248.1	-	5	1380	c.1315C>T	c.(1315-1317)Cat>Tat	p.H439Y	ZNF780B_ENST00000221355.6_Missense_Mutation_p.H291Y	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	439					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCATTGGAATGAATTTTTTGA	0.378000													42	210					0	0	1	0	0
OR6C4	341418	broad.mit.edu	37	12	55945863	55945863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55945863C>T	ENST00000394256.2	+	1	881	c.853C>T	c.(853-855)Ccc>Tcc	p.P285S	RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						CTTACTGAATCCCTTCATATA	0.348000													22	64					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62125259	62125259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62125259G>A	ENST00000433197.2	-	19	2583	c.2488C>T	c.(2488-2490)Ccg>Tcg	p.P830S		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	830	Protein kinase.		P -> L (in an ovarian serous carcinoma sample; somatic mutation).		activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						CAGAAGAACGGGTGTTTGAGC	0.438000													17	50					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77662013	77662013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77662013G>A	ENST00000296043.6	+	5	3640	c.2687G>A	c.(2686-2688)aGc>aAc	p.S896N		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	896					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			CAGCTCTCCAGCGAGCCAGAG	0.711000													10	19					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95338948	95338948	+	Silent	SNP	C	C	T	rs140807207	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:95338948C>T	ENST00000371483.4	+	3	785	c.729C>T	c.(727-729)gtC>gtT	p.V243V	FFAR4_ENST00000371481.4_Intron|FFAR4_ENST00000604414.1_Intron	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		CAAGAGCTGTCGTGACTCACA	0.493000													22	64					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810494	31810494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:31810494G>A	ENST00000446923.2	+	7	2574	c.2183G>A	c.(2182-2184)gGa>gAa	p.G728E	ZEB1_ENST00000560721.2_Missense_Mutation_p.G724E|ZEB1_ENST00000361642.5_Missense_Mutation_p.G745E|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000542815.3_Missense_Mutation_p.G677E|ZEB1_ENST00000320985.10_Missense_Mutation_p.G744E	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	744					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAGCAACAGGGAGAATTATTA	0.428000													22	93					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170964567	170964567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:170964567C>T	ENST00000367759.4	+	13	1386	c.1232C>T	c.(1231-1233)tCc>tTc	p.S411F	MROH9_ENST00000367758.3_Missense_Mutation_p.S411F	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		CCTCTTGGTTCCTACAGGAAA	0.478000													41	108					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48390061	48390061	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48390061C>T	ENST00000224600.4	-	1	930	c.817G>A	c.(817-819)Gag>Aag	p.E273K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	273	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	AAGTCAGACTCGCCTATCCTC	0.677000													10	25					0	0	1	0	0
PNPLA8	50640	broad.mit.edu	37	7	108138000	108138000	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:108138000G>A	ENST00000426128.2	-	5	1505	c.1380C>T	c.(1378-1380)acC>acT	p.T460T	PNPLA8_ENST00000436062.1_Silent_p.T460T|PNPLA8_ENST00000453144.1_Silent_p.T360T|PNPLA8_ENST00000257694.8_Silent_p.T460T|PNPLA8_ENST00000388728.5_Silent_p.T460T|PNPLA8_ENST00000422087.1_Silent_p.T460T|PNPLA8_ENST00000483879.1_5'UTR	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	460	Patatin.				fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						ATTTTCGTAGGGTCTGGAGAG	0.343000													24	46					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73635884	73635884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:73635884G>A	ENST00000261917.3	-	2	2044	c.1051C>T	c.(1051-1053)Ccc>Tcc	p.P351S		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	351					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		TAGTCCACGGGGATGGAGGAA	0.527000													12	72					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16902777	16902777	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16902777G>A	ENST00000430580.2	-	19	2991	c.2104C>T	c.(2104-2106)Caa>Taa	p.Q702*	NBPF1_ENST00000287968.8_Nonsense_Mutation_p.Q67*|NBPF1_ENST00000432949.1_Nonsense_Mutation_p.Q160*	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	702						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CTGAGCTTTTGGACAAGGTGC	0.562000													31	680					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100847882	100847882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100847882C>T	ENST00000554175.1	+	2	800	c.621C>T	c.(619-621)gcC>gcT	p.207_207insA	WDR25_ENST00000335290.6_Silent_p.A207A|WDR25_ENST00000554998.1_Silent_p.A207A|WDR25_ENST00000402312.3_Silent_p.A207A			Q64LD2	WDR25_HUMAN	WD repeat domain 25											central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				CAGGGCGTGCCCCAGCCCCTC	0.547000													40	100					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351410	89351410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89351410G>A	ENST00000301030.4	-	9	2000	c.1540C>T	c.(1540-1542)Ctg>Ttg	p.L514L	ANKRD11_ENST00000378330.2_Silent_p.L514L	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	514	Ser-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GAGCTGAACAGGGAGGGGTCC	0.652000													19	47					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7727852	7727852	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7727852G>A	ENST00000283147.6	+	1	823	c.664_splice	c.e1+1	p.V222_splice		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	222					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					TGTGAACCTGGGTAAGGATTT	0.647000													7	25					0	0	1	0	0
RAB38	23682	broad.mit.edu	37	11	87847224	87847224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:87847224G>A	ENST00000243662.6	-	3	650	c.568C>T	c.(568-570)Ccg>Tcg	p.P190S	RP11-164N3.3_ENST00000528458.1_RNA	NM_022337.2	NP_071732.1	P57729	RAB38_HUMAN	RAB38, member RAS oncogene family	190					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ACGACGTCCGGCTCAATAGAC	0.468000													41	142					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145379722	145379722	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145379722G>A	ENST00000511217.1	+	2	532	c.480G>A	c.(478-480)gaG>gaA	p.E160E	SH3RF2_ENST00000359120.4_Silent_p.E160E			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	160	SH3 1.						ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCTTGATGAGAATTGGTACC	0.557000													21	57					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123302227	123302227	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123302227G>A	ENST00000296513.2	+	4	438	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K	ADAD1_ENST00000388725.2_Missense_Mutation_p.E67K|ADAD1_ENST00000492454.1_3'UTR|ADAD1_ENST00000388724.2_Missense_Mutation_p.E85K	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	85					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding	p.E85K(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						AATACCTAAGGAATTTATAAT	0.368000													33	84					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19632552	19632552	+	Missense_Mutation	SNP	G	G	A	rs79772073		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19632552G>A	ENST00000235835.3	-	6	899	c.878C>T	c.(877-879)tCg>tTg	p.S293L		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	293					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGGCAGCCGAGGTCACACT	0.632000													23	74					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18691100	18691100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18691100C>T	ENST00000433979.1	+	24	3327	c.3211C>T	c.(3211-3213)Cct>Tct	p.P1071S	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.P1071S|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.P1112S	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1071	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GGACCGAGCTCCTTTCATTTT	0.368000													27	51					0	0	1	0	0
REN	5972	broad.mit.edu	37	1	204124271	204124271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204124271G>A	ENST00000367195.2	-	9	1128	c.1085C>T	c.(1084-1086)gCc>gTc	p.A362V	REN_ENST00000272190.8_Missense_Mutation_p.A365V			P00797	RENI_HUMAN	renin	365					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGCGTGGATGGCCAGTGTGCA	0.552000													28	57					0	0	1	0	0
SLC1A7	6512	broad.mit.edu	37	1	53580495	53580495	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53580495C>T	ENST00000371494.4	-	3	493	c.366G>A	c.(364-366)aaG>aaA	p.K122K	SLC1A7_ENST00000371491.4_Silent_p.K122K|RP11-334A14.8_ENST00000439621.1_RNA	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	122						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	CCGTGGTCTCCTTCTGGGCCG	0.612000													11	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179539769	179539769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179539769C>T	ENST00000589042.1	-	150	34833	c.34609G>A	c.(34609-34611)Gaa>Aaa	p.E11537K	TTN_ENST00000342992.6_Missense_Mutation_p.E10236K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E11163K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11300	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTACCTTCAACTGGTAGA	0.333000													12	27					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101715887	101715887	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:101715887G>A	ENST00000342239.3	-	4	1435	c.1344C>T	c.(1342-1344)ccC>ccT	p.P448P	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Silent_p.P448P			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	448					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TTGCTTCTAGGGGAAGAAGGT	0.502000													38	146					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893237	36893237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36893237G>A	ENST00000301807.6	-	14	4975	c.3078C>T	c.(3076-3078)ctC>ctT	p.L1026L	TRANK1_ENST00000429976.2_Silent_p.L1576L|TRANK1_ENST00000428977.2_Silent_p.L1026L	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1576					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGTTGTAAAGGAGGACATCAT	0.383000													6	24					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123022953	123022953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123022953G>A	ENST00000462833.1	-	13	3732	c.2520C>T	c.(2518-2520)ttC>ttT	p.F840F	ADCY5_ENST00000309879.5_Silent_p.F490F|ADCY5_ENST00000491190.1_Silent_p.F473F	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	840					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		GGGTGATGGTGAACACCCCAA	0.617000													15	54					0	0	1	0	0
TM6SF2	53345	broad.mit.edu	37	19	19375544	19375544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19375544G>A	ENST00000389363.4	-	10	1135	c.1063C>T	c.(1063-1065)Ctt>Ttt	p.L355F	AC138430.4_ENST00000586064.2_RNA	NM_001001524.2	NP_001001524.2	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	355						integral to membrane				breast(2)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14			Epithelial(12;0.0151)			GGCCACTGAAGGCAACGGTAG	0.622000													32	45					0	0	1	0	0
NBR1	4077	broad.mit.edu	37	17	41342735	41342735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:41342735C>T	ENST00000422280.1	+	9	1264	c.805C>T	c.(805-807)Ccg>Tcg	p.P269S	NBR1_ENST00000341165.6_Missense_Mutation_p.P269S|NBR1_ENST00000590996.1_Missense_Mutation_p.P269S|NBR1_ENST00000589872.1_Missense_Mutation_p.P269S|NBR1_ENST00000542611.1_Missense_Mutation_p.P248S|NBR1_ENST00000389312.4_Missense_Mutation_p.P269S	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	269					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		CTCCTCTGAACCGTTCTGTCA	0.478000													15	16					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349594	100349594	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100349594C>T	ENST00000542585.1	+	0	2014				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCACCATTCCCTCAGAAAAAC	0.473000													44	90					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50736487	50736487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50736487G>A	ENST00000355832.5	-	4	706	c.628C>T	c.(628-630)Cac>Tac	p.H210Y	ERCC6-PGBD3_ENST00000447839.2_Missense_Mutation_p.H210Y|ERCC6-PGBD3_ENST00000515869.1_Missense_Mutation_p.H210Y|PGBD3_ENST00000603152.1_Missense_Mutation_p.H210Y	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	210					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AGACTGGCGTGATCTAGTTCA	0.458000								Direct reversal of damage;Nucleotide excision repair (NER)					24	71					0	0	1	0	0
MRRF	92399	broad.mit.edu	37	9	125042722	125042722	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125042722C>T	ENST00000344641.3	+	3	496	c.184_splice	c.e3-1	p.A62_splice	MRRF_ENST00000546115.1_Splice_Site_p.A62_splice|MRRF_ENST00000297908.3_Intron|MRRF_ENST00000373727.1_Splice_Site_p.A62_splice|MRRF_ENST00000394315.3_Splice_Site_p.A62_splice|MRRF_ENST00000373730.3_Splice_Site_p.A62_splice|MRRF_ENST00000373729.1_Splice_Site_p.A18_splice|MRRF_ENST00000373723.4_Splice_Site_p.A62_splice|MRRF_ENST00000373728.1_Splice_Site_p.A62_splice	NM_138777.3	NP_620132.1	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor	62					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	12						CACTTTTTAGCCAAAGGGAAA	0.383000													18	58					0	0	1	0	0
SSX5	6758	broad.mit.edu	37	X	48047099	48047099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48047099C>T	ENST00000311798.1	-	8	710	c.658G>A	c.(658-660)Gag>Aag	p.E220K	SSX5_ENST00000376923.1_Missense_Mutation_p.E179K|SSX5_ENST00000347757.1_Missense_Mutation_p.E179K	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						TCGCTGATCTCTTCATAAATC	0.483000													119	122					0	0	1	0	0
NMU	10874	broad.mit.edu	37	4	56496595	56496595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:56496595C>T	ENST00000264218.3	-	2	250	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	NMU_ENST00000511469.1_Missense_Mutation_p.E49K|NMU_ENST00000515325.1_5'UTR|NMU_ENST00000505262.1_Missense_Mutation_p.E49K|NMU_ENST00000507338.1_Missense_Mutation_p.E49K	NM_006681.2	NP_006672.1	P48645	NMU_HUMAN	neuromedin U	49					neuropeptide signaling pathway	extracellular region				lung(3)|ovary(1)|urinary_tract(1)	5	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		AGCTGTTGTTCAGGCTGTAAT	0.294000													8	87					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768165	117768165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117768165C>T	ENST00000317775.6	-	2	1395	c.710G>A	c.(709-711)gGa>gAa	p.G237E	NOS1_ENST00000344089.3_Missense_Mutation_p.G237E|NOS1_ENST00000338101.4_Missense_Mutation_p.G237E	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	237	PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CACCTGGATTCCCATATCTTT	0.557000													23	81					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159654376	159654376	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159654376C>T	ENST00000297267.9	+	11	3032	c.2832C>T	c.(2830-2832)tcC>tcT	p.S944S	FNDC1_ENST00000340366.6_Silent_p.S881S	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	944						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGTACTCCTCCCTGGCCTCCA	0.617000													9	14					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124437990	124437990	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124437990C>T	ENST00000360013.3	+	60	8761	c.8634C>T	c.(8632-8634)tcC>tcT	p.S2878S	KALRN_ENST00000428018.2_Silent_p.S1149S|KALRN_ENST00000291478.4_Silent_p.S1181S	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2877	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GTGGGGTCTCCCCCTTCTTGG	0.527000													21	35					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87913508	87913508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87913508C>T	ENST00000380079.4	-	2	178	c.77G>A	c.(76-78)gGa>gAa	p.G26E	AC003991.3_ENST00000595121.1_RNA|STEAP4_ENST00000414498.1_Missense_Mutation_p.G26E|AC003991.3_ENST00000434733.1_RNA|AC003991.3_ENST00000600908.1_RNA|AC003991.3_ENST00000447758.1_RNA|STEAP4_ENST00000301959.5_Missense_Mutation_p.G26E	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	26					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					ATCACCAGTTCCAAAAATACA	0.383000													16	78					0	0	1	0	0
CRYBA2	1412	broad.mit.edu	37	2	219856910	219856910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219856910C>T	ENST00000295728.2	-	2	453	c.217G>A	c.(217-219)Gga>Aga	p.G73R	CRYBA2_ENST00000392096.2_Missense_Mutation_p.G73R	NM_057093.1	NP_476434.1	P53672	CRBA2_HUMAN	crystallin, beta A2	73	Beta/gamma crystallin 'Greek key' 2.						structural constituent of eye lens			endometrium(1)|lung(3)|prostate(1)	5		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGATAGTCTCCCTTCTCCAGA	0.617000													18	38					0	0	1	0	0
C9orf152	401546	broad.mit.edu	37	9	112963511	112963511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112963511C>T	ENST00000400613.4	-	2	1046	c.437G>A	c.(436-438)gGa>gAa	p.G146E	C9orf152_ENST00000473442.1_Intron	NM_001012993.2	NP_001013011.2	Q5JTZ5	CI152_HUMAN	chromosome 9 open reading frame 152	146										NS(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						TTGATCAGATCCCACAAGCTT	0.532000													69	173					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482500	20482500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20482500C>T	ENST00000573854.1	+	5	816	c.702C>T	c.(700-702)tcC>tcT	p.S234S	ACSM2A_ENST00000417235.2_Silent_p.S155S|ACSM2A_ENST00000536134.1_Intron|ACSM2A_ENST00000396104.2_Silent_p.S234S|ACSM2A_ENST00000219054.6_Silent_p.S234S|ACSM2A_ENST00000575690.1_Silent_p.S234S|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	234					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CAGAACATTCCTACTCGAGCC	0.498000													15	79					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142571444	142571444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142571444C>T	ENST00000359396.3	-	13	1790	c.1545G>A	c.(1543-1545)gaG>gaA	p.E515E		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	515					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					CCTCGGGGTCCTCTGTCTGGA	0.587000													15	140					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40045876	40045876	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40045876C>T	ENST00000336649.4	+	12	1956	c.1956C>T	c.(1954-1956)atC>atT	p.I652I	CACNA1I_ENST00000407673.1_Silent_p.I611I|CACNA1I_ENST00000404898.1_Silent_p.I611I|CACNA1I_ENST00000402142.3_Silent_p.I646I|CACNA1I_ENST00000401624.1_Silent_p.I646I|CACNA1I_ENST00000400164.3_Silent_p.I611I			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	646					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ACCGGGGCATCATGATGGCCA	0.677000													9	33					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22051671	22051671	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22051671C>T	ENST00000306385.5	+	10	1951	c.1281C>T	c.(1279-1281)ttC>ttT	p.F427F	BMP1_ENST00000354870.5_3'UTR|BMP1_ENST00000397816.3_Silent_p.F427F|BMP1_ENST00000397814.3_Silent_p.F427F|BMP1_ENST00000306349.8_Silent_p.F427F	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	427	CUB 1.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GAAAGGGCTTCTTTGCAGTCT	0.592000													30	47					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228559601	228559601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228559601C>T	ENST00000570156.2	+	105	24067	c.23993C>T	c.(23992-23994)tCt>tTt	p.S7998F	OBSCN_ENST00000366707.4_Missense_Mutation_p.S4675F|OBSCN_ENST00000422127.1_Missense_Mutation_p.S7041F	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7041					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AAGCAGGGTTCTGCCCCCCAG	0.672000													12	27					0	0	1	0	0
C12orf76	400073	broad.mit.edu	37	12	110495058	110495058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110495058G>A	ENST00000309050.5	-	4	599	c.235C>T	c.(235-237)Cct>Tct	p.P79S	C12orf76_ENST00000548191.1_Intron|C12orf76_ENST00000548936.1_Intron	NM_207435.1	NP_997318.1	Q8N812	CL076_HUMAN	chromosome 12 open reading frame 76	79										endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6						AGCTCTGCAGGGAGGATGTGC	0.502000													16	34					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52367790	52367790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52367790C>T	ENST00000296585.5	+	18	2401	c.2258C>T	c.(2257-2259)tCt>tTt	p.S753F		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	753					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GTTGTCAACTCTTTGGATTTG	0.453000													19	43					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80044325	80044325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80044325G>A	ENST00000306749.2	-	22	3755	c.3537C>T	c.(3535-3537)ccC>ccT	p.P1179P		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1179					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	ACAACAGCCGGGGCAGTTCCT	0.677000													17	31					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13363829	13363829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:13363829G>A	ENST00000254508.5	-	35	4861	c.4779C>T	c.(4777-4779)acC>acT	p.T1593T		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1593					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TCTGGGTGGGGGTGCACTCGC	0.622000													31	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179552902	179552902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179552902G>A	ENST00000589042.1	-	127	32471	c.32247C>T	c.(32245-32247)tcC>tcT	p.S10749S	TTN_ENST00000342992.6_Silent_p.S9505S|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.S10432S|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10432	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAACTGAAATGGACACACCTT	0.393000													54	139					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	959657	959657	+	Silent	SNP	C	C	T	rs149827249		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:959657C>T	ENST00000265846.5	-	4	555	c.336G>A	c.(334-336)aaG>aaA	p.K112K	ADAP1_ENST00000539900.1_Silent_p.K123K|ADAP1_ENST00000449296.2_Silent_p.K40K|ADAP1_ENST00000463358.1_5'UTR	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	112	Arf-GAP.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						GTCGCTCGTACTTGGCCCGGA	0.682000													9	27					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48729266	48729266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48729266C>T	ENST00000316623.5	-	53	6843	c.6388G>A	c.(6388-6390)Gaa>Aaa	p.E2130K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2130	EGF-like 36; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TCTTTGCATTCGTCCATATCT	0.343000													16	53					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32635512	32635512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32635512C>T	ENST00000373625.3	+	13	1367	c.1274C>T	c.(1273-1275)cCc>cTc	p.P425L	KPNA6_ENST00000545542.1_Missense_Mutation_p.P430L|KPNA6_ENST00000537234.1_Missense_Mutation_p.P422L	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	425					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TGCATCAAACCCCTATGTGAC	0.542000													50	144					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4228965	4228965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:4228965C>T	ENST00000379453.4	-	1	756	c.640G>A	c.(640-642)Gcc>Acc	p.A214T		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	214					cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	AGGATGGCGGCCGCCTTGCGC	0.687000													4	6					0	0	1	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919877	142919877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142919877G>A	ENST00000408947.3	+	1	748	c.706G>A	c.(706-708)Gac>Aac	p.D236N		NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	236					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					AGGGTCCAGGGACCCCAGCAT	0.507000													12	167					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354001	57354001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57354001C>T	ENST00000314922.3	-	2	710	c.634G>A	c.(634-636)Ggc>Agc	p.G212S	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.G212S	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	212					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CTCATGAAGCCCCCATATCGC	0.537000													57	89					0	0	1	0	0
YEATS4	8089	broad.mit.edu	37	12	69756579	69756579	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:69756579C>T	ENST00000247843.2	+	2	333	c.63C>T	c.(61-63)atC>atT	p.I21I	YEATS4_ENST00000548020.1_Silent_p.I21I	NM_006530.2	NP_006521.1	O95619	YETS4_HUMAN	YEATS domain containing 4	21					histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)	5	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			GTGTTACTATCGTTAAACCAA	0.308000													21	60					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233752796	233752796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:233752796C>T	ENST00000264051.3	-	9	1572	c.1294G>A	c.(1294-1296)Gag>Aag	p.E432K	NGEF_ENST00000373552.4_Missense_Mutation_p.E340K|NGEF_ENST00000539537.1_Missense_Mutation_p.E155K	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	432	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TCAGACCTCTCTTCTACCCTC	0.488000													29	62					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157475585	157475585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157475585G>A	ENST00000389413.3	-	12	1849	c.1746C>T	c.(1744-1746)gaC>gaT	p.D582D	PTPRN2_ENST00000409483.1_Silent_p.D573D|PTPRN2_ENST00000404321.2_Silent_p.D634D|PTPRN2_ENST00000389416.4_Silent_p.D594D|PTPRN2_ENST00000389418.4_Silent_p.D611D	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	611						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACTTGGTGGAGTCTTCTTGCT	0.572000													18	33					0	0	1	0	0
CARD16	114769	broad.mit.edu	37	11	104912255	104912255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:104912255G>A	ENST00000375706.2	-	3	483	c.466C>T	c.(466-468)Ctt>Ttt	p.L156F	CASP1_ENST00000415981.2_Intron|CARD16_ENST00000375704.3_3'UTR|CASP1_ENST00000598974.1_Intron|CASP1_ENST00000594519.1_Intron|CASP1_ENST00000593315.1_Intron	NM_001017534.1	NP_001017534.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						TTGGTTCTAAGAAAAAGCCAC	0.383000													46	88					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74289945	74289945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74289945G>A	ENST00000262765.5	-	4	544	c.365C>T	c.(364-366)tCt>tTt	p.S122F		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	122							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						TGTGCCACCAGATCCTGATGC	0.577000													5	89					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99932090	99932090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:99932090G>A	ENST00000524871.1	+	10	1417	c.1127G>A	c.(1126-1128)gGa>gAa	p.G376E	CNTN5_ENST00000527185.1_Missense_Mutation_p.G376E|CNTN5_ENST00000528682.1_Missense_Mutation_p.G376E|CNTN5_ENST00000279463.3_Missense_Mutation_p.G376E|CNTN5_ENST00000418526.2_Missense_Mutation_p.G302E	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	376	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AACTCACGTGGAAAAAATTCC	0.423000													31	50					0	0	1	0	0
ACSL3	2181	broad.mit.edu	37	2	223806250	223806250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:223806250C>T	ENST00000357430.3	+	17	2572	c.2041C>T	c.(2041-2043)Cgt>Tgt	p.R681C	ACSL3_ENST00000392066.3_Missense_Mutation_p.R681C	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	681					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding	p.R681C(5)		cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	AGTAAAAATTCGTTTGAGTCC	0.378000			T	ETV1	prostate								32	55					0	0	1	0	0
KBTBD13	390594	broad.mit.edu	37	15	65370117	65370117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65370117G>A	ENST00000432196.2	+	1	964	c.964G>A	c.(964-966)Gag>Aag	p.E322K		NM_001101362.2	NP_001094832.1	C9JR72	KBTBD_HUMAN	kelch repeat and BTB (POZ) domain containing 13	322						cytoplasm				lung(1)|prostate(1)|skin(1)	3						CGCCGTGGTGGAGTACGCAGT	0.731000													8	10					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68405072	68405072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68405072C>T	ENST00000219334.5	-	3	1616	c.1013G>A	c.(1012-1014)aGg>aAg	p.R338K	SMPD3_ENST00000563226.1_Missense_Mutation_p.R338K|SMPD3_ENST00000568373.1_Missense_Mutation_p.R338K	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	338					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	GGGGTGCCGCCTCCTGCGTGC	0.662000													16	31					0	0	1	0	0
ICAM3	3385	broad.mit.edu	37	19	10449579	10449579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10449579G>A	ENST00000160262.5	-	2	330	c.122C>T	c.(121-123)cCt>cTt	p.P41L	ICAM3_ENST00000589261.1_5'UTR	NM_002162.3	NP_002153.2	P32942	ICAM3_HUMAN	intercellular adhesion molecule 3	41					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	13			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			AGAGAGCACAGGGTTCTGGGG	0.552000													19	63					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063345	9063345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9063345G>A	ENST00000397910.4	-	3	24304	c.24101C>T	c.(24100-24102)tCa>tTa	p.S8034L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8036	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATTTCAACTGAGGTGCTGCT	0.468000													38	86					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35786728	35786728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35786728G>A	ENST00000361922.4	+	4	409	c.259G>A	c.(259-261)Ggc>Agc	p.G87S	MAG_ENST00000392213.3_Missense_Mutation_p.G87S|MAG_ENST00000537831.2_Missense_Mutation_p.G62S|MAG_ENST00000597035.1_Intron	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	87	Ig-like V-type.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GAGCTTCCAGGGCCGCAGCCG	0.632000													58	167					0	0	1	0	0
TEKT1	83659	broad.mit.edu	37	17	6719205	6719205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:6719205C>T	ENST00000338694.2	-	4	562	c.433G>A	c.(433-435)Ggc>Agc	p.G145S	TEKT1_ENST00000535086.1_5'UTR	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	145					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				GCCATAATGCCCTGGATGATC	0.557000													26	35					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55956220	55956220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:55956220C>T	ENST00000263923.4	-	23	3390	c.3095G>A	c.(3094-3096)cGa>cAa	p.R1032Q	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1032	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.R1032Q(2)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GAGGATATTTCGTGCCGCCAG	0.448000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			28	89					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136113	40136113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:40136113C>T	ENST00000278198.2	-	2	3693	c.1730G>A	c.(1729-1731)gGa>gAa	p.G577E	LRRC4C_ENST00000528697.1_Missense_Mutation_p.G577E|LRRC4C_ENST00000530763.1_Missense_Mutation_p.G577E|LRRC4C_ENST00000527150.1_Missense_Mutation_p.G577E			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	577					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGGTGTGTCTCCCGTAATCTC	0.458000													60	58					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907435	12907435	+	Silent	SNP	C	C	T	rs2076062		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12907435C>T	ENST00000317869.6	-	2	933	c.708G>A	c.(706-708)gtG>gtA	p.V236V		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						ACTCCATCTTCACATGAGTCT	0.478000													15	257					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44477310	44477310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44477310G>A	ENST00000360584.2	-	2	363	c.172C>T	c.(172-174)Ctc>Ttc	p.L58F	SLC6A9_ENST00000492434.2_Intron|SLC6A9_ENST00000372310.3_Intron|SLC6A9_ENST00000372306.3_Intron|SLC6A9_ENST00000537678.1_Intron|SLC6A9_ENST00000475075.2_Intron|SLC6A9_ENST00000372307.3_Intron|SLC6A9_ENST00000357730.2_Intron	NM_201649.3	NP_964012.2	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	58						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CAGACTTTGAGGACAGACTCT	0.617000													21	53					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11197563	11197563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:11197563C>T	ENST00000337414.4	-	7	2211	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	ARHGAP6_ENST00000380718.1_Missense_Mutation_p.E447K|ARHGAP6_ENST00000413512.3_Missense_Mutation_p.E256K|ARHGAP6_ENST00000380736.1_Missense_Mutation_p.E244K|ARHGAP6_ENST00000534860.1_Missense_Mutation_p.E272K|ARHGAP6_ENST00000491514.1_5'UTR|ARHGAP6_ENST00000303025.6_Missense_Mutation_p.E244K|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.E479K	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	447	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CGGTCAAATTCCTCACGTAAC	0.517000													16	25					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79363967	79363967	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:79363967C>T	ENST00000444841.1	-	0	371																											TGGTGCCACTCTCTTTAATCA	0.522000													17	31					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50537852	50537852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:50537852C>T	ENST00000444124.2	-	12	1259	c.1059G>A	c.(1057-1059)ctG>ctA	p.L353L	DDC_ENST00000431062.1_Silent_p.L260L|DDC_ENST00000357936.5_Silent_p.L353L|DDC_ENST00000426377.1_Silent_p.L275L	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	353					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ATCTTCTGCCCAGTGGTATCT	0.418000													32	97					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981739	7981739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7981739G>A	ENST00000328600.2	-	2	1581	c.1420C>T	c.(1420-1422)Cat>Tat	p.H474Y		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	474	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GACATGGCATGAAAAAAGTCC	0.532000													13	124					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71709035	71709035	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:71709035C>T	ENST00000258104.3	+	3	448	c.171C>T	c.(169-171)atC>atT	p.I57I	DYSF_ENST00000410041.1_Silent_p.I58I|DYSF_ENST00000429174.2_Silent_p.I57I|DYSF_ENST00000409744.1_Silent_p.I58I|DYSF_ENST00000410020.3_Silent_p.I58I|DYSF_ENST00000394120.2_Silent_p.I58I|DYSF_ENST00000409366.1_Silent_p.I58I|DYSF_ENST00000409582.3_Silent_p.I57I|DYSF_ENST00000413539.2_Silent_p.I57I|DYSF_ENST00000409651.1_Silent_p.I58I|DYSF_ENST00000409762.1_Silent_p.I57I	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	57	C2 1.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TCAAGGGCATCCCCCTGGACC	0.537000													11	26					0	0	1	0	0
C1QTNF9B	387911	broad.mit.edu	37	13	24465472	24465472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:24465472C>T	ENST00000382137.3	-	3	1026	c.958G>A	c.(958-960)Gat>Aat	p.D320N	C1QTNF9B_ENST00000556521.1_5'UTR|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B_ENST00000382145.1_3'UTR|C1QTNF9B-AS1_ENST00000382133.4_RNA|C1QTNF9B_ENST00000382140.2_Missense_Mutation_p.D320N	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	320	C1q.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						GTTGTGTCATCGTCCTCATCA	0.517000													26	96					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20761100	20761100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20761100C>T	ENST00000400451.2	+	5	2291	c.1777C>T	c.(1777-1779)Ctc>Ttc	p.L593F	ZNF74_ENST00000405993.1_Missense_Mutation_p.L561F|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Missense_Mutation_p.L593F	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	593					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			caaacacctgctcagcacata	0.592000													7	60					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370507	240370507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240370507G>A	ENST00000319653.9	+	5	2625	c.2395G>A	c.(2395-2397)Gac>Aac	p.D799N		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	799	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AGTCCAGCTCGACAGCCATCA	0.572000													22	74					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160059264	160059264	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:160059264T>A	ENST00000327245.5	-	13	2338	c.1492A>T	c.(1492-1494)Agc>Tgc	p.S498C	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	498					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTTTTTGGCTTCTCATAGTT	0.582000													7	54					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47682233	47682233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47682233C>T	ENST00000273857.4	-	8	1056	c.1057G>A	c.(1057-1059)Ggg>Agg	p.G353R	CORIN_ENST00000504584.1_Intron|CORIN_ENST00000502252.1_Missense_Mutation_p.G286R|CORIN_ENST00000505909.1_Intron|CORIN_ENST00000508498.1_Missense_Mutation_p.G214R	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	353	LDL-receptor class A 3.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						ATGCAGCGCCCGTCCCCGCAG	0.532000													11	36					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645662	45645662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:45645662G>A	ENST00000303230.4	-	2	531	c.474C>T	c.(472-474)gtC>gtT	p.V158V		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	158						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CTGGTATGATGACTAGATTTC	0.318000													30	66					0	0	1	0	0
CHKB-CPT1B	386593	broad.mit.edu	37	22	51017915	51017915	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:51017915G>A	ENST00000453634.1	-	2	47	c.48C>T	c.(46-48)ttC>ttT	p.F16F	CHKB_ENST00000406938.2_Silent_p.F351F|CHKB-CPT1B_ENST00000452668.1_Intron																							GACCCCAGAAGAAATGGGATG	0.562000													6	35					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45929264	45929264	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45929264G>A	ENST00000323084.4	-	10	1637	c.1572C>T	c.(1570-1572)ttC>ttT	p.F524F	TSPEAR-AS1_ENST00000451035.1_RNA|TSPEAR_ENST00000397916.1_Silent_p.F456F	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	524					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CTGCAGCACCGAACGTCTAGG	0.622000													8	30					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144620343	144620343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144620343G>A	ENST00000262577.5	-	2	1225	c.1194C>T	c.(1192-1194)gcC>gcT	p.A398A		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	398					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CCTTGCTGCTGGCCTCCGACT	0.642000													21	71					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56387432	56387432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56387432C>T	ENST00000355701.3	-	21	4657	c.3787G>A	c.(3787-3789)Gaa>Aaa	p.E1263K	BZRAP1_ENST00000268893.6_Missense_Mutation_p.E1203K|BZRAP1_ENST00000343736.4_Missense_Mutation_p.E1263K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1263	Poly-Glu.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tcttcctcttcctcctGGATG	0.577000													28	65					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149905338	149905338	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:149905338G>A	ENST00000439741.2	-	10	1196	c.946C>T	c.(946-948)Caa>Taa	p.Q316*	MTMR11_ENST00000406732.3_Nonsense_Mutation_p.Q288*|MTMR11_ENST00000369140.3_Nonsense_Mutation_p.Q244*|MTMR11_ENST00000361405.6_Intron|MTMR11_ENST00000492824.1_5'UTR	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	316	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			TGGGCAAGTTGGACATCTGCA	0.582000													40	93					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55145665	55145665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55145665C>T	ENST00000414150.2	+	13	2606	c.2328C>T	c.(2326-2328)tcC>tcT	p.S776S	MROH7_ENST00000409996.1_Silent_p.S344S|MROH7_ENST00000339553.5_Silent_p.S776S|MROH7_ENST00000454855.2_Silent_p.S294S|MROH7_ENST00000545244.1_Silent_p.S344S|MROH7_ENST00000395690.2_Silent_p.S776S|MROH7_ENST00000421030.2_Silent_p.S776S					maestro heat-like repeat family member 7																		TGGCTAGCTCCTTCATGACCG	0.607000													41	209					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78320047	78320047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78320047C>T	ENST00000582970.1	+	29	8055	c.7912C>T	c.(7912-7914)Ctc>Ttc	p.L2638F	RNF213_ENST00000508628.2_Missense_Mutation_p.L2687F|RNF213_ENST00000336301.6_Missense_Mutation_p.L711F	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CTTTGTCAGCCTCAGGGACGT	0.537000													25	77					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7749579	7749579	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7749579C>T	ENST00000254846.5	+	6	809	c.420C>T	c.(418-420)ttC>ttT	p.F140F	KDM6B_ENST00000448097.2_Silent_p.F140F	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	140					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						GAGGAAGCTTCGCTGAGCTGG	0.622000													10	12					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47583854	47583854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47583854C>T	ENST00000172229.3	+	3	527	c.402C>T	c.(400-402)ctC>ctT	p.L134L	NGFR_ENST00000504201.1_Silent_p.L40L|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	134					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GCTCGGGCCTCGTGTTCTCCT	0.692000													9	20					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135428793	135428793	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:135428793C>T	ENST00000394143.1	+	6	3219	c.2928C>T	c.(2926-2928)acC>acT	p.T976T	GPR112_ENST00000370652.1_Silent_p.T976T|GPR112_ENST00000394141.1_Silent_p.T771T|GPR112_ENST00000412101.1_Silent_p.T771T|GPR112_ENST00000287534.4_Silent_p.T913T	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	976					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TATCAGAAACCAGTTTCTCCA	0.512000													16	112					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113527243	113527243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113527243G>A	ENST00000505019.1	-	9	2848	c.2723C>T	c.(2722-2724)tCt>tTt	p.S908F	C4orf21_ENST00000309071.5_Missense_Mutation_p.S908F	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	908										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TCCCGAGGAAGAGAACTAGGA	0.323000													31	69					0	0	1	0	0
CEBPE	1053	broad.mit.edu	37	14	23588189	23588189	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23588189C>T	ENST00000206513.5	-	1	636	c.112G>A	c.(112-114)Gcc>Acc	p.A38T		NM_001805.3	NP_001796.2	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein (C/EBP), epsilon	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		TCAATGGAGGCCTCATGCTCA	0.642000													21	94					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47583819	47583819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47583819G>A	ENST00000172229.3	+	3	492	c.367G>A	c.(367-369)Gag>Aag	p.E123K	NGFR_ENST00000504201.1_Missense_Mutation_p.E29K|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	123					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					TGGGCGCTGCGAGGCGTGCCG	0.697000													11	16					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105905303	105905303	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105905303T>C	ENST00000357060.3	-	31	3990	c.3875A>G	c.(3874-3876)aAa>aGa	p.K1292R	WDR96_ENST00000428666.1_Missense_Mutation_p.K1264R	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1292										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AAATTCCTTTTTAAAGCTGCG	0.363000													11	51					0	0	1	0	0
BNIPL	149428	broad.mit.edu	37	1	151015480	151015480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151015480G>A	ENST00000295294.7	+	5	845	c.236G>A	c.(235-237)aGg>aAg	p.R79K	BNIPL_ENST00000368931.3_Missense_Mutation_p.R161K	NM_001159642.1	NP_001153114.1	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein like	161					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(1)|lung(4)|skin(1)	10	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACAGCTGAAAGGCTGGGCCGA	0.552000													55	105					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271300	59271300	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59271300C>T	ENST00000313253.1	+	1	252	c.252C>T	c.(250-252)gaC>gaT	p.D84D		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						TCTTGCTGGACCTTCTGTCAA	0.478000													92	241					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210948733	210948733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:210948733G>A	ENST00000367007.4	-	10	2157	c.1988C>T	c.(1987-1989)tCc>tTc	p.S663F	KCNH1_ENST00000271751.4_Missense_Mutation_p.S690F	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	690					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCGGGAGAAGGAATGGGAGAA	0.473000													18	31					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15073099	15073099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15073099C>T	ENST00000598504.1	-	8	2009	c.650G>A	c.(649-651)gGg>gAg	p.G217E	SLC1A6_ENST00000544886.2_Missense_Mutation_p.G217E|SLC1A6_ENST00000221742.3_Missense_Mutation_p.G217E|SLC1A6_ENST00000430939.2_Missense_Mutation_p.G153E|SLC1A6_ENST00000600144.1_Missense_Mutation_p.G217E	NM_001272087.1	NP_001259016.1	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	217					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	CGGCTCAGACCCGTTCTCTGT	0.552000													15	142					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147494021	147494021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147494021G>A	ENST00000359874.3	+	21	2057	c.1984G>A	c.(1984-1986)Ggc>Agc	p.G662S	SPINK5_ENST00000256084.7_Missense_Mutation_p.G662S|SPINK5_ENST00000398454.1_Missense_Mutation_p.G662S	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	662	Kazal-like 10.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAGACCCATGGCAACAAGTG	0.458000													31	48					0	0	1	0	0
ACTR3B	57180	broad.mit.edu	37	7	152520487	152520487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:152520487C>T	ENST00000256001.8	+	8	879	c.745C>T	c.(745-747)Ccc>Tcc	p.P249S	ACTR3B_ENST00000377776.3_Missense_Mutation_p.P249S|ACTR3B_ENST00000537264.1_Missense_Mutation_p.P161S|ACTR3B_ENST00000397282.2_Missense_Mutation_p.P161S	NM_020445.5	NP_065178.1	Q9P1U1	ARP3B_HUMAN	ARP3 actin-related protein 3 homolog B (yeast)	249					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding			breast(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	13		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		TGATGTGGATCCCCGGAAGTG	0.418000													71	136					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90012335	90012335	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90012335A>C	ENST00000405460.2	+	43	9332	c.9236A>C	c.(9235-9237)aAc>aCc	p.N3079T		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3079					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTATCATTTAACAACAGTGAG	0.388000													4	33					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127323759	127323759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:127323759G>A	ENST00000265056.7	+	4	677	c.433G>A	c.(433-435)Gag>Aag	p.E145K		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	145	Interaction with MYST2 (By similarity).				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GGAGGACGAGGAGCGCCCTGC	0.647000													12	20					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9609185	9609185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:9609185C>T	ENST00000310430.6	+	19	2925	c.2899C>T	c.(2899-2901)Cct>Tct	p.P967S	TNKS_ENST00000518281.1_Missense_Mutation_p.P730S	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	967					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		CTGTTTTAAACCTCAGGCTAC	0.488000													44	247					0	0	1	0	0
AMY2A	279	broad.mit.edu	37	1	104160591	104160591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:104160591G>A	ENST00000414303.2	+	2	248	c.184G>A	c.(184-186)Gaa>Aaa	p.E62K		NM_000699.2	NP_000690.1	P04746	AMYP_HUMAN	amylase, alpha 2A (pancreatic)	62					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	TCCACCAAATGAAAATGTTGC	0.328000													39	170					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79725486	79725486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:79725486C>T	ENST00000275034.4	-	14	1417	c.1250G>A	c.(1249-1251)gGa>gAa	p.G417E		NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	417					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		ATCTTCTATTCCTTGAAGGTT	0.303000													16	25					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1051955	1051955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1051955C>T	ENST00000263094.6	+	22	3208	c.2977C>T	c.(2977-2979)Ctc>Ttc	p.L993F	ABCA7_ENST00000435683.2_Missense_Mutation_p.L855F|ABCA7_ENST00000433129.1_Missense_Mutation_p.L993F	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	993	ABC transporter 1.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGCTGATCCTCTCCACCCA	0.672000													11	78					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12313759	12313759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12313759C>T	ENST00000256186.2	+	2	335	c.44C>T	c.(43-45)tCa>tTa	p.S15L		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	15	Ser-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcttccttcatcgtcttcc	0.488000													15	45					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579081	44579081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44579081G>A	ENST00000289547.4	-	2	970	c.915C>T	c.(913-915)ttC>ttT	p.F305F	NPC1L1_ENST00000546276.1_Silent_p.F305F|NPC1L1_ENST00000423141.1_Silent_p.F305F|NPC1L1_ENST00000381160.3_Silent_p.F305F	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	305					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GGGCCACACGGAATCCCACAA	0.602000													39	74					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143560784	143560784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:143560784C>T	ENST00000517894.1	+	8	2556	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F	BAI1_ENST00000323289.5_Silent_p.F554F			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	554	TSP type-1 5.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GGCCCTTCTTCGGGGGAGCAG	0.706000													7	10					0	0	1	0	0
WDR47	22911	broad.mit.edu	37	1	109529264	109529264	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109529264G>A	ENST00000357672.3	-	9	2097	c.1722C>T	c.(1720-1722)atC>atT	p.I574I	WDR47_ENST00000400794.3_Silent_p.I610I|WDR47_ENST00000369962.3_Silent_p.I602I|WDR47_ENST00000369965.4_Silent_p.I603I|WDR47_ENST00000361054.3_Silent_p.I574I			O94967	WDR47_HUMAN	WD repeat domain 47	602										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		TGTCTTCTAGGATATTAATAC	0.323000													20	43					0	0	1	0	0
AGBL4	84871	broad.mit.edu	37	1	49119122	49119122	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:49119122C>T	ENST00000371839.1	-	8	842	c.724_splice	c.e8-1	p.G242_splice	AGBL4_ENST00000371838.1_Splice_Site_p.G242_splice|AGBL4_ENST00000334103.7_5'UTR	NM_032785.3	NP_116174.3	Q5VU57	CBPC6_HUMAN	ATP/GTP binding protein-like 4	242					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15				Colorectal(2;0.00349)|COAD - Colon adenocarcinoma(2;0.0037)		AGTCAATGATCCCTAGGGAAA	0.453000													3	6					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27151188	27151188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27151188G>A	ENST00000288699.6	+	5	824	c.666G>A	c.(664-666)gaG>gaA	p.E222E	DPYSL5_ENST00000401478.1_Silent_p.E222E	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	222					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCGTCCAGAGGAGGTGAGAA	0.478000													8	32					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84531792	84531792	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:84531792C>T	ENST00000527857.1	+	0	1814					NR_026851.1																						CAATCCCAGCCCTACTACCTA	0.498000													15	30					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074263	9074263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9074263C>T	ENST00000397910.4	-	3	13386	c.13183G>A	c.(13183-13185)Gga>Aga	p.G4395R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4397	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGCAGCTCCAGTAGGACCT	0.463000													45	101					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569451	241569451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241569451G>A	ENST00000319838.5	+	6	1024	c.82G>A	c.(82-84)Ggc>Agc	p.G28S	GPR35_ENST00000430267.1_Missense_Mutation_p.G28S|GPR35_ENST00000407714.1_Missense_Mutation_p.G28S|GPR35_ENST00000403859.1_Missense_Mutation_p.G28S|GPR35_ENST00000438013.2_Missense_Mutation_p.G59S	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	28						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		CGCCTACTTGGGCGTCCTGCT	0.627000													19	64					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57103257	57103257	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:57103257G>A	ENST00000439986.4	-	11	1141	c.1104C>T	c.(1102-1104)ttC>ttT	p.F368F	CCBE1_ENST00000398179.2_Silent_p.F97F	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	368					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				GAGGTAAAGGGAACTCCTCTG	0.532000													55	163					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13071780	13071780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:13071780G>A	ENST00000399002.2	+	5	931	c.657G>A	c.(655-657)ctG>ctA	p.L219L	SPTLC3_ENST00000378194.4_Silent_p.L219L	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	219					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	CTAAGTTCCTGAATGTGGAAG	0.428000													15	137					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21478515	21478515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:21478515G>A	ENST00000281523.2	-	5	1138	c.620C>T	c.(619-621)tCg>tTg	p.S207L	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	207						nucleus	nucleic acid binding|zinc ion binding	p.S207L(1)		NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						CTTGCATAGCGAACAGTAAAG	0.478000													17	125					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127253908	127253908	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:127253908G>A	ENST00000341640.2	-	4	645	c.440C>T	c.(439-441)cCc>cTc	p.P147L	PAX4_ENST00000463946.1_Missense_Mutation_p.P145L|PAX4_ENST00000378740.2_Missense_Mutation_p.P147L|PAX4_ENST00000338516.3_Missense_Mutation_p.P155L	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	155					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P147L(1)		cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GCCACTATGGGGAGTGAGGAC	0.562000													13	51					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31852266	31852266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31852266G>A	ENST00000395728.3	-	20	2844	c.2845C>T	c.(2845-2847)Ccc>Tcc	p.P949S	EHMT2_ENST00000375528.4_Missense_Mutation_p.P915S|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375530.4_Missense_Mutation_p.P858S|EHMT2_ENST00000375537.4_Missense_Mutation_p.P892S			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	892					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						GAGCGCTCGGGAGTCAGGTCC	0.602000													42	109					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047750	9047750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9047750G>A	ENST00000397910.4	-	5	34084	c.33881C>T	c.(33880-33882)tCt>tTt	p.S11294F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11296	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGACTGTAGAAGGCATAGT	0.473000													9	26					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104640107	104640107	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:104640107G>A	ENST00000315264.7	+	9	1893	c.1515G>A	c.(1513-1515)agG>agA	p.R505R	KIF26A_ENST00000423312.2_Silent_p.R644R			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	644	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CGGCTGGCAGGGCCGGGGAGG	0.667000													12	18					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1403202	1403202	+	Silent	SNP	G	G	A	rs138475489	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:1403202G>A	ENST00000270349.9	-	13	1729	c.1602C>T	c.(1600-1602)ttC>ttT	p.F534F	SLC6A3_ENST00000453492.2_Silent_p.F534F	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	534					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CCACGACCACGAACTGCAACC	0.632000													9	17					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	98002508	98002508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98002508C>T	ENST00000224337.5	-	3	287	c.146G>A	c.(145-147)cGa>cAa	p.R49Q	BLNK_ENST00000371176.2_Missense_Mutation_p.R49Q|BLNK_ENST00000413476.2_Missense_Mutation_p.R49Q|BLNK_ENST00000427367.2_Missense_Mutation_p.R49Q|BLNK_ENST00000495266.1_Missense_Mutation_p.R49Q	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	49					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		GTAGTCCCTTCGAGGAACACT	0.388000													44	81					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29284944	29284944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29284944G>A	ENST00000266943.6	-	4	1466	c.1097C>T	c.(1096-1098)tCt>tTt	p.S366F	SLC46A3_ENST00000380814.4_Missense_Mutation_p.S366F	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	366					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		CCGTAGAACAGAGAATGGCAC	0.388000													32	88					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242812010	242812010	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242812010G>A	ENST00000343216.3	+	1	130	c.102G>A	c.(100-102)ctG>ctA	p.L34L		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	34						integral to membrane											AGCACAGCCTGGTCCCGGGAT	0.682000													7	9					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154492783	154492783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154492783G>A	ENST00000368482.4	+	5	983	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	TDRD10_ENST00000368480.3_Missense_Mutation_p.E49K	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	49	RRM.						nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GTTGTAGGAGGAAATTCTGTA	0.423000													20	43					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030026	95030026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95030026G>A	ENST00000557004.1	+	2	628	c.207G>A	c.(205-207)gaG>gaA	p.E69E	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Silent_p.E69E|SERPINA4_ENST00000298841.5_Silent_p.E69E			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	69					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		TCGCTTCGGAGACCCCGGGGA	0.602000													35	79					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136529031	136529031	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:136529031T>A	ENST00000371872.4	-	21	2994	c.2737A>T	c.(2737-2739)Agg>Tgg	p.R913W	SARDH_ENST00000371868.1_Missense_Mutation_p.R363W|SARDH_ENST00000422262.2_Missense_Mutation_p.R745W|SARDH_ENST00000439388.1_Missense_Mutation_p.R913W	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	913					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CCCTTCACCCTCTTGTTGTTG	0.592000													35	121					0	0	1	0	0
ANXA9	8416	broad.mit.edu	37	1	150955861	150955861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150955861C>T	ENST00000368947.4	+	4	599	c.123C>T	c.(121-123)ttC>ttT	p.F41F	ANXA9_ENST00000474997.1_3'UTR	NM_003568.2	NP_003559.2	O76027	ANXA9_HUMAN	annexin A9	41					cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(4)|skin(2)	8	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTTGAACTTCAGCGTGGACA	0.607000													7	17					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3795352	3795352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3795352G>A	ENST00000262367.5	-	22	4649	c.3840C>T	c.(3838-3840)ttC>ttT	p.F1280F	CREBBP_ENST00000382070.3_Silent_p.F1242F	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1280	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGCAATCAACGAAACTAGGAG	0.512000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						10	21					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41385254	41385254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41385254G>A	ENST00000400454.1	-	33	6223	c.5746C>T	c.(5746-5748)Cca>Tca	p.P1916S		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1916				HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTGGTGCCTGGACCACCTCGG	0.522000													23	43					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588200	247588200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247588200G>A	ENST00000366497.2	+	4	2235	c.1455G>A	c.(1453-1455)gaG>gaA	p.E485E	NLRP3_ENST00000391828.3_Silent_p.E485E|NLRP3_ENST00000336119.3_Silent_p.E485E|NLRP3_ENST00000391827.2_Silent_p.E485E|NLRP3_ENST00000348069.2_Silent_p.E485E|NLRP3_ENST00000366496.2_Silent_p.E485E|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	485	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCTGTTTGAGGAGTCCGACC	0.567000													14	35					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58734141	58734141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:58734141C>T	ENST00000305921.3	+	5	1431	c.1199C>T	c.(1198-1200)tCc>tTc	p.S400F		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	400					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			GACAGCCCTTCCTATAATAGT	0.393000													43	93					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124412747	124412747	+	Silent	SNP	C	C	T	rs61745404	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124412747C>T	ENST00000306842.2	-	1	828	c.804G>A	c.(802-804)gaG>gaA	p.E268E		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		CTTTCCCTTGCTCGAGGGGCA	0.438000													24	73					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233296028	233296028	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233296028C>T	ENST00000258229.8	-	19	3752		c.e19+1		PCNXL2_ENST00000520463.1_Splice_Site|PCNXL2_ENST00000488780.2_Splice_Site	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				ATATTACTAACCTCTCACTTC	0.418000													14	29					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849774	73849774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:73849774G>A	ENST00000523207.1	+	3	2772	c.2184G>A	c.(2182-2184)caG>caA	p.Q728Q		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	728					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GTGCACCACAGACCCCGCCCA	0.532000													56	110					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57864435	57864435	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57864435A>G	ENST00000228682.2	+	12	2003	c.1912A>G	c.(1912-1914)Agg>Ggg	p.R638G	GLI1_ENST00000546141.1_Missense_Mutation_p.R597G|GLI1_ENST00000543426.1_Missense_Mutation_p.R510G	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	638					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			GGTCACCCGGAGGGCCAGTGA	0.622000													18	46					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62855838	62855838	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:62855838G>A	ENST00000584306.1	-	11	4956	c.4426C>T	c.(4426-4428)Cag>Tag	p.Q1476*	LRRC37A3_ENST00000339474.5_Nonsense_Mutation_p.Q594*|LRRC37A3_ENST00000334962.5_Nonsense_Mutation_p.Q453*|LRRC37A3_ENST00000319651.5_Nonsense_Mutation_p.Q1476*|LRRC37A3_ENST00000400877.3_Nonsense_Mutation_p.Q514*	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1476						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TGGGTTAGCTGAATTTCAAAC	0.512000													119	328					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115428861	115428861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:115428861C>T	ENST00000369522.3	+	14	1361	c.1121C>T	c.(1120-1122)tCg>tTg	p.S374L	SYCP1_ENST00000369518.1_Missense_Mutation_p.S374L	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	374					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTGCTCATTCGTTTGTGGTT	0.308000													48	104					0	0	1	0	0
SLC25A52	147407	broad.mit.edu	37	18	29340392	29340392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29340392C>T	ENST00000269205.5	-	1	451	c.263G>A	c.(262-264)cGa>cAa	p.R88Q	SLC25A52_ENST00000579441.2_Missense_Mutation_p.R78Q	NM_001034172.2	NP_001029344.3	Q3SY17	MCAR2_HUMAN	solute carrier family 25, member 52	78					transport	integral to membrane|mitochondrial inner membrane											ATACAAATTTCGAAATCCATC	0.463000													43	85					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	145002	145002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145002C>T	ENST00000283426.6	+	4	854	c.804C>T	c.(802-804)gcC>gcT	p.A268A		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	268					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GTCCAGCTGCCCCTGCCGTCT	0.612000													14	34					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375885	113375885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:113375885G>A	ENST00000316407.4	-	7	5054	c.4644C>T	c.(4642-4644)tcC>tcT	p.S1548S	KIAA2018_ENST00000478658.1_Silent_p.S1548S|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1548	Gln-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TCTTGGATCGGGATTGGTCAG	0.502000													15	70					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116631459	116631459	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:116631459G>T	ENST00000395715.3	-	3	1443	c.866C>A	c.(865-867)tCc>tAc	p.S289Y	TRPS1_ENST00000220888.5_Missense_Mutation_p.S276Y|TRPS1_ENST00000519076.1_Missense_Mutation_p.S230Y|TRPS1_ENST00000520276.1_Missense_Mutation_p.S280Y|TRPS1_ENST00000519674.1_Missense_Mutation_p.S276Y	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	276					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GAAGTCTTTGGAATGGCTGAA	0.468000									Langer-Giedion syndrome				28	38					1.74197e-06	1.74586e-06	1	1	0
SQLE	6713	broad.mit.edu	37	8	126015634	126015634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:126015634G>A	ENST00000265896.5	+	2	1406	c.508G>A	c.(508-510)Ggt>Agt	p.G170S	SQLE_ENST00000523430.1_Missense_Mutation_p.G75S	NM_003129.3	NP_003120.2	Q14534	ERG1_HUMAN	squalene epoxidase	170					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	CCTGCAGCCGGGTGGTTATCA	0.443000													50	225					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77286782	77286782	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77286782C>T	ENST00000376896.2	+	9	1801	c.1189C>T	c.(1189-1191)Cag>Tag	p.Q397*	RORB_ENST00000396204.2_Nonsense_Mutation_p.Q408*	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	408	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						ACATGTGATTCAGAAGAATCA	0.443000													20	42					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182195	100182195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100182195C>T	ENST00000554176.1	+	3	949	c.283C>T	c.(283-285)Cgc>Tgc	p.R95C	CYP46A1_ENST00000423126.2_Missense_Mutation_p.R151C|CYP46A1_ENST00000261835.3_Missense_Mutation_p.R248C			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	248					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GGAGAGCATTCGCTTCCTGCG	0.607000													34	59					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156646890	156646890	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156646890G>A	ENST00000368223.3	-	1	299	c.167C>T	c.(166-168)gCc>gTc	p.A56V		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	56	Coil 1B.|Rod.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCGTCGTCGGCATGCGCCCG	0.721000													8	15					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72350309	72350309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72350309G>A	ENST00000389916.4	+	18	2455	c.2317G>A	c.(2317-2319)Gag>Aag	p.E773K		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	773					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						AGAGAGGAAGGAGATCCTGAC	0.657000													34	94					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28136759	28136759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:28136759G>A	ENST00000316334.3	-	5	1144	c.1015C>T	c.(1015-1017)Caa>Taa	p.Q339*		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	339	PDZ 2.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		AGAGCCACTTGGAAAATCTCT	0.488000													31	92					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38750779	38750779	+	Splice_Site	SNP	G	G	A	rs35125773		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38750779G>A	ENST00000359357.3	+	15	1862		c.e15-1		DNAH8_ENST00000441566.1_Splice_Site|DNAH8_ENST00000449981.2_Splice_Site					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TAAAAAAACAGAAAAACTCAG	0.323000													17	52					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092458	30092458	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30092458C>T	ENST00000567636.1	+	0	833					NR_003558.1																						GATGTATGGCCGTAAAGTGGG	0.532000													53	103					0	0	1	0	0
TULP2	7288	broad.mit.edu	37	19	49391246	49391246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49391246G>A	ENST00000221399.3	-	8	1053	c.909C>T	c.(907-909)ccC>ccT	p.P303P		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	303					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GGTAGTAGAGGGGGAACAAGC	0.612000													18	61					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831246	61831246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61831246G>A	ENST00000280772.1	-	37	9584	c.9393C>T	c.(9391-9393)acC>acT	p.T3131T	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3131					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTGTATAAAAGGTCCCCCTGG	0.408000													43	184					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25333878	25333878	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25333878C>T	ENST00000546682.1	+	0	586				SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						GTTGTTGGATCCCTTCTGAAT	0.478000													30	49					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272052	52272052	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52272052G>A	ENST00000598776.1	+	2	913	c.141G>A	c.(139-141)gtG>gtA	p.V47V	FPR2_ENST00000340023.6_Silent_p.V47V|FPR2_ENST00000598953.1_Silent_p.V47V	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	47					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						ATGGGCTTGTGATCTGGGTGG	0.557000													27	84					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10480586	10480586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:10480586C>T	ENST00000382483.3	-	2	349	c.126G>A	c.(124-126)ggG>ggA	p.G42G	RP1L1_ENST00000329335.3_5'UTR	NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	42					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		ACCGTGGATCCCCTCGCTTGA	0.652000													30	61					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332205	70332205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70332205G>A	ENST00000338508.4	-	32	4195	c.4196C>T	c.(4195-4197)tCc>tTc	p.S1399F	SHANK2_ENST00000423696.2_Missense_Mutation_p.S1019F|SHANK2_ENST00000409161.1_Missense_Mutation_p.S802F|SHANK2_ENST00000449833.2_Missense_Mutation_p.S803F			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1019					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CAAGTCCACGGATGCCAGAGG	0.567000													29	70					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578475	7578475	+	Missense_Mutation	SNP	G	G	A	rs137852790		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7578475G>A	ENST00000420246.2	-	5	587	c.455C>T	c.(454-456)cCg>cTg	p.P152L	TP53_ENST00000445888.2_Missense_Mutation_p.P152L|TP53_ENST00000269305.4_Missense_Mutation_p.P152L|TP53_ENST00000359597.4_Missense_Mutation_p.P152L|TP53_ENST00000455263.2_Missense_Mutation_p.P152L|TP53_ENST00000413465.2_Missense_Mutation_p.P152L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	152	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(66)|p.P152R(8)|p.0?(8)|p.T150fs*16(6)|p.?(5)|p.P153fs*28(5)|p.P152fs*18(5)|p.P152fs*14(5)|p.P152Q(4)|p.P59L(2)|p.P20L(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P59R(1)|p.P20R(1)|p.P152fs*28(1)|p.T57fs*16(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.P152fs*27(1)|p.Q144_G154del11(1)|p.Q144fs*16(1)|p.T18fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGCCGGGCGGGGGTGTGGA	0.612000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	41					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247751770	247751770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247751770C>T	ENST00000320065.1	+	1	109	c.109C>T	c.(109-111)Ctg>Ttg	p.L37L	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATATTGATTCTGTATTTACT	0.398000													61	149					0	0	1	0	0
CDK19	23097	broad.mit.edu	37	6	110942510	110942510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:110942510G>A	ENST00000368911.3	-	12	1353	c.1174C>T	c.(1174-1176)Cct>Tct	p.P392S	CDK19_ENST00000413605.2_Missense_Mutation_p.P268S|CDK19_ENST00000323817.3_Missense_Mutation_p.P332S	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	392	Gln-rich.						ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						GCCTGTGGAGGGGCTGCTGCC	0.632000													61	84					0	0	1	0	0
RSL1D1	26156	broad.mit.edu	37	16	11941590	11941590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11941590G>A	ENST00000571133.1	-	3	391	c.319C>T	c.(319-321)Cct>Tct	p.P107S	RSL1D1_ENST00000542106.1_5'UTR	NM_015659.2	NP_056474.2	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	107					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	15						GTCTTTTCAGGAGTTGAATTG	0.348000													12	48					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37467050	37467050	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37467050G>A	ENST00000381792.2	-	14	1718	c.1578C>T	c.(1576-1578)acC>acT	p.T526T	TMPRSS6_ENST00000406725.1_Silent_p.T526T|TMPRSS6_ENST00000346753.3_Silent_p.T535T|TMPRSS6_ENST00000406856.1_Silent_p.T526T			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	535	LDL-receptor class A 2.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						CACACTGGAAGGTGAATGTCC	0.637000													15	35					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23410682	23410682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:23410682C>T	ENST00000379361.4	+	3	1907	c.1047C>T	c.(1045-1047)tcC>tcT	p.S349S		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	349	SSD.				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						AAATGTTATCCTCCTGGAGGA	0.418000													28	11					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4854665	4854665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:4854665C>T	ENST00000252318.2	+	5	1268	c.931C>T	c.(931-933)Cgt>Tgt	p.R311C		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	311						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						TGACAACATTCGTTTTGACAC	0.498000													25	39					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117307098	117307098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117307098C>T	ENST00000003084.6	+	27	4511	c.4379C>T	c.(4378-4380)tCt>tTt	p.S1460F	CFTR_ENST00000454343.1_Missense_Mutation_p.S1399F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1460					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AAGTGCAAGTCTAAGCCCCAG	0.512000									Cystic Fibrosis				13	49					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15364971	15364971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15364971G>A	ENST00000263377.2	-	11	2371	c.2150C>T	c.(2149-2151)tCc>tTc	p.S717F	BRD4_ENST00000360016.5_Missense_Mutation_p.S717F|BRD4_ENST00000371835.4_Missense_Mutation_p.S717F	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	717	Ser-rich.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			ACCTGTTTCGGAGTCTTCGCT	0.547000			T	C15orf55	lethal midline carcinoma of young people								7	43					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21453372	21453372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:21453372C>T	ENST00000307378.6	-	9	1540	c.820G>A	c.(820-822)Gga>Aga	p.G274R	SLCO1A2_ENST00000452078.1_Missense_Mutation_p.G274R|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.G142R|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.G272R|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.G142R	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	274					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						GTCTCTAGTCCTTCCTTTGGA	0.388000													13	52					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6953543	6953543	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6953543C>T	ENST00000278319.5	+	3	628	c.40C>T	c.(40-42)Cga>Tga	p.R14*	ZNF215_ENST00000529903.1_Nonsense_Mutation_p.R14*|ZNF215_ENST00000527171.1_3'UTR|ZNF215_ENST00000414517.2_Nonsense_Mutation_p.R14*	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	14					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CTCAAAACCTCGAAACCTGTC	0.468000													33	73					0	0	1	0	0
SLAMF8	56833	broad.mit.edu	37	1	159802914	159802914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159802914C>T	ENST00000289707.5	+	3	765	c.616C>T	c.(616-618)Cct>Tct	p.P206S	SLAMF8_ENST00000471286.1_3'UTR|SLAMF8_ENST00000368104.4_Missense_Mutation_p.P97S	NM_020125.2	NP_064510.1	Q9P0V8	SLAF8_HUMAN	SLAM family member 8	206	Ig-like C2-type.					integral to membrane				endometrium(2)|large_intestine(4)|lung(6)	12	all_hematologic(112;0.0597)					TGTCTCCAACCCTGTCAGCTG	0.557000													31	81					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22834550	22834550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22834550C>T	ENST00000404138.1	+	8	1928	c.1417C>T	c.(1417-1419)Ctc>Ttc	p.L473F	ZBTB40_ENST00000374651.4_Missense_Mutation_p.L361F|ZBTB40_ENST00000375647.4_Missense_Mutation_p.L473F	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	473					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TCATGAAAACCTCTCTGAGAT	0.393000													31	108					0	0	1	0	0
TOB2	10766	broad.mit.edu	37	22	41833288	41833288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41833288G>A	ENST00000327492.3	-	2	768	c.62C>T	c.(61-63)cCc>cTc	p.P21L		NM_016272.3	NP_057356.1	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	21					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						CCGGCGCCGGGGCAGCTTGTT	0.537000													34	53					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017372	93017372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:93017372C>T	ENST00000523629.1	-	6	1166	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K	RUNX1T1_ENST00000521553.1_Missense_Mutation_p.E201K|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.E201K|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.E201K|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.E249K|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.E211K|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.E201K|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.E238K|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.E211K	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	238					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E238K(1)|p.E201K(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCCCGTTTTCGTTCACATCG	0.542000													15	127					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	5605450	5605450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:5605450C>T	ENST00000215473.6	+	6	3490	c.3490C>T	c.(3490-3492)Cta>Tta	p.L1164L				Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	1164					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GGCCTCTGCTCTATGCCACAG	0.552000													37	19					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73735384	73735384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:73735384G>A	ENST00000427855.1	+	26	3722	c.3620G>A	c.(3619-3621)gGg>gAg	p.G1207E	PAPLN_ENST00000340738.5_Missense_Mutation_p.G1180E|PAPLN_ENST00000381166.3_Intron|PAPLN_ENST00000554301.1_Missense_Mutation_p.G1207E|PAPLN_ENST00000555445.1_Missense_Mutation_p.G1191E			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	1207	Ig-like C2-type 3.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCCTACCAGGGGAGCCAGGCA	0.592000													14	31					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841134	13841134	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13841134G>A	ENST00000265104.4	-	34	5694	c.5590C>T	c.(5590-5592)Ctg>Ttg	p.L1864L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1864	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGTAGCTCCAGGAAAGCCTGA	0.403000									Kartagener syndrome				23	73					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27147881	27147881	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27147881C>A	ENST00000288699.6	+	3	546	c.388C>A	c.(388-390)Ctc>Atc	p.L130I	DPYSL5_ENST00000401478.1_Missense_Mutation_p.L130I	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	130					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATTACGCCCTCCACGTGGG	0.607000													13	33					0.000151284	0.000151503	1	1	0
PEAK1	79834	broad.mit.edu	37	15	77471795	77471795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:77471795G>A	ENST00000560626.2	-	4	2949	c.2474C>T	c.(2473-2475)cCt>cTt	p.P825L	PEAK1_ENST00000558305.1_Missense_Mutation_p.P825L|PEAK1_ENST00000312493.4_Missense_Mutation_p.P825L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	825	Pro-rich.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										CTCACCACTAGGCTGAGATGT	0.502000													36	129					0	0	1	0	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89916703	89916703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:89916703G>A	ENST00000548729.1	-	3	1917	c.1615C>T	c.(1615-1617)Cca>Tca	p.P539S	POC1B_ENST00000549035.1_Intron|GALNT4_ENST00000529983.2_Missense_Mutation_p.P542S|POC1B_ENST00000313546.3_Intron|POC1B_ENST00000541909.1_Intron|POC1B-GALNT4_ENST00000413530.1_Missense_Mutation_p.P370S|POC1B-GALNT4_ENST00000547474.1_3'UTR|POC1B_ENST00000549504.1_Intron|POC1B_ENST00000393179.4_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					CCTGAGTGTGGGTGAAAAATA	0.403000													9	77					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908686	103908686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103908686C>T	ENST00000302259.3	+	1	1379	c.1136C>T	c.(1135-1137)tCt>tTt	p.S379F	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	379					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CAAGATGAGTCTTCGGACAAG	0.463000													16	57					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56742819	56742819	+	Missense_Mutation	SNP	G	G	A	rs149351309		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56742819G>A	ENST00000314128.4	-	17	1488	c.1465C>T	c.(1465-1467)Ccc>Tcc	p.P489S	STAT2_ENST00000418572.2_3'UTR|STAT2_ENST00000557235.1_Missense_Mutation_p.P485S|STAT2_ENST00000556539.1_5'UTR			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	489					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						GGGGCCTTGGGGGGGTTGGAG	0.602000													18	52					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17084760	17084760	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:17084760G>A	ENST00000455405.2	-	0	256																											TCCTTTACTAGAGACCCCGCG	0.572000													8	35					0	0	1	0	0
CEACAM7	1087	broad.mit.edu	37	19	42187864	42187864	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42187864G>A	ENST00000006724.3	-	3	759	c.558C>T	c.(556-558)ctC>ctT	p.L186L	CEACAM7_ENST00000401731.1_Silent_p.L186L|CEACAM7_ENST00000602225.1_Intron|CEACAM7_ENST00000338196.4_Intron	NM_006890.3	NP_008821.1	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 7	186	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		GACTGACCAGGAGGCTCTGAT	0.478000													47	113					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189586385	189586385	+	Nonsense_Mutation	SNP	C	C	T	rs113993966		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:189586385C>T	ENST00000264731.3	+	8	1098	c.1009C>T	c.(1009-1011)Cga>Tga	p.R337*	TP63_ENST00000392461.3_Nonsense_Mutation_p.R243*|TP63_ENST00000418709.2_Nonsense_Mutation_p.R337*|TP63_ENST00000449992.1_Nonsense_Mutation_p.R158*|TP63_ENST00000437221.1_Nonsense_Mutation_p.R243*|TP63_ENST00000320472.5_Nonsense_Mutation_p.R337*|TP63_ENST00000392463.2_Nonsense_Mutation_p.R243*|TP63_ENST00000392460.3_Nonsense_Mutation_p.R337*|TP63_ENST00000456148.1_Nonsense_Mutation_p.R243*|TP63_ENST00000382063.4_Nonsense_Mutation_p.R252*|TP63_ENST00000354600.5_Nonsense_Mutation_p.R243*|TP63_ENST00000440651.2_Nonsense_Mutation_p.R337*	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	337			R -> Q (in ADULT syndrome; confers novel transcription activation capacity on isoform 6).		anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		AGTCCTGGGCCGACGCTGCTT	0.478000										HNSCC(45;0.13)			17	68					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81050844	81050844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81050844C>T	ENST00000334512.5	+	10	1241	c.669C>T	c.(667-669)ttC>ttT	p.F223F	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	223					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGCAGCAGTTCTCAGCCAAGG	0.662000													39	67					0	0	1	0	0
PCBP2	5094	broad.mit.edu	37	12	53853075	53853075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53853075C>T	ENST00000603815.1	+	6	613	c.263C>T	c.(262-264)aCc>aTc	p.T88I	PCBP2_ENST00000359462.5_Missense_Mutation_p.T88I|PCBP2_ENST00000552296.2_Missense_Mutation_p.T88I|PCBP2_ENST00000548933.1_Missense_Mutation_p.T88I|PCBP2_ENST00000549863.1_Missense_Mutation_p.T88I|PCBP2_ENST00000546463.1_Missense_Mutation_p.T88I|PCBP2_ENST00000455667.3_Missense_Mutation_p.T88I|PCBP2_ENST00000552819.1_Missense_Mutation_p.T88I|PCBP2_ENST00000437231.1_Missense_Mutation_p.T88I|PCBP2_ENST00000359282.5_Missense_Mutation_p.T88I|PCBP2_ENST00000447282.1_Missense_Mutation_p.T88I|PCBP2_ENST00000541275.1_Missense_Mutation_p.T88I|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000439930.3_Missense_Mutation_p.T88I	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	88					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						AGCTCTATGACCAATAGCACA	0.483000													31	98					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74401374	74401374	+	Silent	SNP	G	G	A	rs144543657	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74401374G>A	ENST00000319380.7	-	3	565	c.501C>T	c.(499-501)atC>atT	p.I167I		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	167							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						TGTTGACGTCGATCACCGTGC	0.622000													18	42					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112786202	112786202	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:112786202G>A	ENST00000295408.4	+	19	3018	c.2761G>A	c.(2761-2763)Gac>Aac	p.D921N	MERTK_ENST00000409780.1_Missense_Mutation_p.D745N|MERTK_ENST00000421804.2_Missense_Mutation_p.D921N			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	921					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						AGAAGTTCATGACAGCAAACC	0.537000													43	113					0	0	1	0	0
TDO2	6999	broad.mit.edu	37	4	156838606	156838606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156838606C>T	ENST00000536354.2	+	10	1020	c.956C>T	c.(955-957)tCa>tTa	p.S319L		NM_005651.3	NP_005642.1	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	319					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	18	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	GACATAGATTCACTGATGACC	0.433000													21	83					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938364	2938364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2938364C>T	ENST00000378404.2	+	1	319	c.114C>T	c.(112-114)atC>atT	p.I38I		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	38						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		TCAGCTCCATCGTGGGGCACC	0.597000													15	38					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94884139	94884139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94884139G>A	ENST00000357742.4	+	6	955	c.955G>A	c.(955-957)Gat>Aat	p.D319N	MCTP2_ENST00000543482.1_Missense_Mutation_p.D319N|MCTP2_ENST00000451018.3_Missense_Mutation_p.D319N|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	319					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAAACAGGGTGATTTCAAGAG	0.373000													14	67					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481610	140481610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140481610C>T	ENST00000231130.2	+	1	1377	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		459	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.F459F(1)		NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.602000													86	199					0	0	1	0	0
ZNF439	90594	broad.mit.edu	37	19	11978185	11978185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11978185C>T	ENST00000304030.2	+	3	501	c.301C>T	c.(301-303)Cca>Tca	p.P101S	ZNF439_ENST00000592534.1_Intron|ZNF439_ENST00000455282.1_5'UTR	NM_152262.2	NP_689475.1	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	101	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(7)|pancreas(1)|skin(2)	27						AACTTTTACCCCAGTTCCAGA	0.388000													16	219					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67064772	67064772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:67064772G>A	ENST00000315962.4	+	8	1519	c.1146G>A	c.(1144-1146)gtG>gtA	p.V382V	TRIM55_ENST00000350034.4_Intron|TRIM55_ENST00000353317.5_Silent_p.V382V|TRIM55_ENST00000276573.7_Silent_p.V382V	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	382						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			TCTCTCAGGTGGAGCTGCAGG	0.552000													15	67					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96967012	96967012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96967012C>T	ENST00000341686.3	+	4	576	c.451C>T	c.(451-453)Cgc>Tgc	p.R151C	C10orf129_ENST00000394005.3_Missense_Mutation_p.R151C|C10orf129_ENST00000430183.1_5'UTR	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	151					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CAAGAAAATTCGCTATCAATT	0.458000													19	74					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47489498	47489498	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47489498C>T	ENST00000371901.3	+	1	259	c.9C>T	c.(7-9)ttC>ttT	p.F3F	CYP4X1_ENST00000538609.1_Intron	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	3						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						CCATGGAATTCTCCTGGCTGG	0.697000													16	68					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143013423	143013423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143013423G>A	ENST00000343257.2	+	1	205	c.118G>A	c.(118-120)Ggg>Agg	p.G40R		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	40					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CTCTGAGAATGGGGGCCTCCA	0.607000													47	131					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119463029	119463029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:119463029G>A	ENST00000273390.5	+	14	1965	c.1888G>A	c.(1888-1890)Gag>Aag	p.E630K	RP11-169N13.4_ENST00000489428.2_RNA	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		GGAGGAGGACGAGATATTTAA	0.562000													17	38					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33998705	33998705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:33998705C>T	ENST00000373381.4	-	64	10292	c.10116G>A	c.(10114-10116)gaG>gaA	p.E3372E		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3228						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGGTGCGGTGCTCGGAGCCAC	0.662000													17	22					0	0	1	0	0
NFIC	4782	broad.mit.edu	37	19	3449086	3449086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3449086C>T	ENST00000589123.1	+	7	1126	c.1006C>T	c.(1006-1008)Cgc>Tgc	p.R336C	NFIC_ENST00000341919.3_Missense_Mutation_p.R345C|NFIC_ENST00000586919.1_Missense_Mutation_p.R312C|NFIC_ENST00000346156.5_Missense_Mutation_p.R312C|NFIC_ENST00000590282.1_Missense_Mutation_p.R345C|NFIC_ENST00000395111.3_Missense_Mutation_p.R336C|NFIC_ENST00000443272.2_Missense_Mutation_p.R345C	NM_001245005.1|NM_205843.2	NP_001231934.1|NP_995315.1	P08651	NFIC_HUMAN	nuclear factor I/C (CCAAT-binding transcription factor)	345					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		GGACTCTCCCCGCCTCTCCAG	0.672000													21	26					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14834375	14834375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14834375G>A	ENST00000261170.3	-	5	784	c.648C>T	c.(646-648)ttC>ttT	p.F216F	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	216					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						GTTCGTGGGAGAAATAGGAAA	0.418000													14	64					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70931458	70931458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70931458G>A	ENST00000264436.3	-	4	761	c.317C>T	c.(316-318)tCc>tTc	p.S106F	ADD2_ENST00000413157.2_Missense_Mutation_p.S106F|ADD2_ENST00000407644.2_Missense_Mutation_p.S106F|ADD2_ENST00000355733.3_Missense_Mutation_p.S106F|ADD2_ENST00000430656.1_Missense_Mutation_p.S122F	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	106					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CATACTCATGGAAGATGTCGG	0.602000													24	86					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184295503	184295503	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184295503C>T	ENST00000330394.2	+	7	1989	c.1537C>T	c.(1537-1539)Ctt>Ttt	p.L513F	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	513	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCTGGACGGGCTTCGGCCTGA	0.642000													34	93					0	0	1	0	0
EPC2	26122	broad.mit.edu	37	2	149511697	149511697	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:149511697C>T	ENST00000258484.6	+	4	695	c.661C>T	c.(661-663)Cga>Tga	p.R221*		NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)	221					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		AATGCAAACTCGAAAGGTAAT	0.338000													6	13					0	0	1	0	0
NCK2	8440	broad.mit.edu	37	2	106509458	106509458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:106509458C>T	ENST00000451463.2	+	4	523	c.247C>T	c.(247-249)Cct>Tct	p.P83S	NCK2_ENST00000393349.2_Silent_p.S323S|NCK2_ENST00000522586.1_Missense_Mutation_p.P83S|NCK2_ENST00000233154.4_Silent_p.S323S	NM_001004722.3	NP_001004722.1	O43639	NCK2_HUMAN	NCK adaptor protein 2	0					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						TCTCCGTGTCCCTTAAAGCGT	0.567000													20	73					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605745	171605745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:171605745G>A	ENST00000037502.5	-	3	894	c.835C>T	c.(835-837)Ccc>Tcc	p.P279S		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	279	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGGGTGTAGGGGTAGGTGGGC	0.537000													46	62					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7295530	7295530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7295530C>T	ENST00000537408.1	+	10	2180	c.1642C>T	c.(1642-1644)Cgc>Tgc	p.R548C	CLSTN3_ENST00000266546.6_Missense_Mutation_p.R536C			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	536					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GCGCTCAGGTCGCCTGGAGAG	0.587000													17	45					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102508940	102508940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:102508940C>T	ENST00000321521.9	+	20	2941	c.2368C>T	c.(2368-2370)Ctt>Ttt	p.L790F	PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.L790F|PPIP5K2_ENST00000358359.3_Missense_Mutation_p.L790F			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	790					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TCGCTCAGACCTTCAGAGGAC	0.363000													29	54					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31816148	31816148	+	Missense_Mutation	SNP	G	G	A	rs143438972	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:31816148G>A	ENST00000446923.2	+	9	3674	c.3283G>A	c.(3283-3285)Gag>Aag	p.E1095K	ZEB1_ENST00000560721.2_Missense_Mutation_p.E1091K|ZEB1_ENST00000361642.5_Missense_Mutation_p.E1112K|ZEB1_ENST00000542815.3_Missense_Mutation_p.E1044K|ZEB1_ENST00000320985.10_Missense_Mutation_p.E1111K	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1111	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAAGTAGGCGAGAGTAGTGA	0.378000													10	19					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382676	22382676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22382676C>T	ENST00000328795.4	+	1	295	c.204C>T	c.(202-204)ttC>ttT	p.F68F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ACTTGGCCTTCCTGGATGCAT	0.483000													29	284					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545019	82545019	+	Silent	SNP	G	G	A	rs76835434	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82545019G>A	ENST00000423517.2	-	7	12620	c.12283C>T	c.(12283-12285)Cta>Tta	p.L4095L	PCLO_ENST00000437081.1_Silent_p.L815L|PCLO_ENST00000333891.8_Silent_p.L4095L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4026					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AAAGGTGCTAGGAAATCTGTC	0.448000													7	20					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151878029	151878029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:151878029G>A	ENST00000355193.2	-	36	7134	c.6916C>T	c.(6916-6918)Cca>Tca	p.P2306S	KMT2C_ENST00000262189.6_Missense_Mutation_p.P2306S					lysine (K)-specific methyltransferase 2C																		TGAGATCTTGGAGTCATTGGA	0.512000													31	67					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140207969	140207969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140207969G>A	ENST00000529310.1	+	1	407	c.293G>A	c.(292-294)cGg>cAg	p.R98Q	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.R98Q|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1												p.R98Q(2)		NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTGCGGGCGGAGCGCGGAG	0.587000													93	303					0	0	1	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89100768	89100768	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89100768G>A	ENST00000393525.3	+	0	1242																											TAAATGAATTGAATCATTTGA	0.333000													22	49					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76928222	76928222	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:76928222C>T	ENST00000376217.2	-	17	1882	c.1632G>A	c.(1630-1632)aaG>aaA	p.K544K	GDPD4_ENST00000315938.4_3'UTR			Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	544					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						CTTGGTGTTCCTTTCCACTCT	0.478000													6	25					0	0	1	0	0
CTAG2	30848	broad.mit.edu	37	X	153881735	153881735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153881735C>T	ENST00000247306.4	-	1	118	c.55G>A	c.(55-57)Gga>Aga	p.G19R	CTAG2_ENST00000369585.3_Missense_Mutation_p.G19R	NM_020994.3	NP_066274.1	O75638	CTAG2_HUMAN	cancer/testis antigen 2	19	Gly-rich.					centrosome				central_nervous_system(1)|endometrium(1)|lung(6)|ovary(1)|pancreas(1)	10	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCAGGGCCTCCTGGGCCATCA	0.721000													4	7					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33639752	33639752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33639752C>T	ENST00000361680.2	+	5	693	c.615C>T	c.(613-615)ttC>ttT	p.F205F	WDR88_ENST00000355868.3_Silent_p.F205F			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	205								p.F205F(1)		breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					TCTCAGGCTTCGACGTGGATC	0.493000													61	161					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454371	84454371	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:84454371G>A	ENST00000377084.2	-	1	2157	c.1272C>T	c.(1270-1272)gaC>gaT	p.D424D		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	424						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCCACCTGAGGTCCAAAAGGT	0.468000													28	260					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28501425	28501425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28501425G>A	ENST00000261609.7	-	18	2664	c.2556C>T	c.(2554-2556)ttC>ttT	p.F852F		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	852					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTAAACCAAGGAATTCCGGGT	0.517000													9	12					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70418945	70418945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70418945G>A	ENST00000381280.4	+	2	443	c.190G>A	c.(190-192)Gag>Aag	p.E64K	SMOC1_ENST00000555917.1_3'UTR|SMOC1_ENST00000361956.3_Missense_Mutation_p.E64K	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	64	Kazal-like.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		CAGGTCCTACGAGTCCATGTG	0.577000													41	108					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142586786	142586786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:142586786C>T	ENST00000378004.3	+	21	2367	c.2012C>T	c.(2011-2013)tCa>tTa	p.S671L	ARHGAP26_ENST00000274498.4_Missense_Mutation_p.S671L|ARHGAP26_ENST00000486650.1_Intron	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	671	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCCAACTTCACCCCTCTCG	0.592000													33	114					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70017060	70017060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70017060G>A	ENST00000355303.5	+	22	2570	c.2265G>A	c.(2263-2265)ctG>ctA	p.L755L	ANO1_ENST00000398543.2_Silent_p.L609L|ANO1_ENST00000538023.1_Silent_p.L755L|ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000530676.1_Silent_p.L609L|ANO1_ENST00000531349.1_Silent_p.L464L	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	755					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TTGCGCTGCTGAACAACATCA	0.582000													4	19					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114636424	114636424	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:114636424C>T	ENST00000393296.1	-	7	1594	c.1515_splice	c.e7-1	p.G506_splice	SYT6_ENST00000369547.1_Splice_Site_p.G421_splice			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	506	Necessary for cell membrane association (isoform 2) (By similarity).				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCGAGGGTTTCCCTGGTGAAA	0.458000													6	67					0	0	1	0	0
HTATIP2	10553	broad.mit.edu	37	11	20403763	20403763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:20403763C>T	ENST00000451739.2	+	4	922	c.481C>T	c.(481-483)Cgt>Tgt	p.R161C	HTATIP2_ENST00000443524.2_Missense_Mutation_p.R161C|HTATIP2_ENST00000421577.2_Missense_Mutation_p.R161C|HTATIP2_ENST00000531058.1_Missense_Mutation_p.R115C|HTATIP2_ENST00000419348.2_Missense_Mutation_p.R195C	NM_001098522.1	NP_001091992.1	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa	161					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity			large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						AAAATTTGATCGTTACTCTGT	0.343000													25	53					0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223201	35223201	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:35223201C>T	ENST00000338513.1	+	2	443	c.270C>T	c.(268-270)ctC>ctT	p.L90L		NM_005268.3	NP_005259.1	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	90					cell communication|epidermis development	connexon complex|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				CCTCACTGCTCGTGGTCATGC	0.617000													18	77					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141334096	141334096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141334096G>A	ENST00000325617.5	-	2	577	c.137C>T	c.(136-138)tCc>tTc	p.S46F	CLGN_ENST00000414773.1_Missense_Mutation_p.S46F|CLGN_ENST00000537281.1_Missense_Mutation_p.S46F	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	46					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					TACCTCTGAGGAAAGTTCACT	0.318000													17	41					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11631189	11631189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11631189G>A	ENST00000262442.3	+	28	5832	c.5764G>A	c.(5764-5766)Gat>Aat	p.D1922N	DNAH9_ENST00000454412.2_Missense_Mutation_p.D1922N	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1922	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGGCTGCTTTGATGAGTTTAA	0.488000													21	23					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51923199	51923199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:51923199C>T	ENST00000371117.3	-	16	1709	c.1434G>A	c.(1432-1434)ctG>ctA	p.L478L	PKHD1_ENST00000340994.4_Silent_p.L478L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	478					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CATCAGGATTCAGCCAGGTGT	0.552000													40	101					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26242165	26242165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26242165G>A	ENST00000335473.7	+	19	3717	c.3467G>A	c.(3466-3468)aGg>aAg	p.R1156K	MYO18B_ENST00000536101.1_Missense_Mutation_p.R1156K|MYO18B_ENST00000407587.2_Missense_Mutation_p.R1157K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1156	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCCCTGCAGAGGAGCCGCATG	0.667000													15	26					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95921884	95921884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:95921884G>A	ENST00000334258.5	-	5	981	c.967C>T	c.(967-969)Ctg>Ttg	p.L323L	SYNE3_ENST00000554873.1_Silent_p.L80L|SYNE3_ENST00000557275.1_Silent_p.L323L|SYNE3_ENST00000553340.1_Silent_p.L323L	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						AGGCCCCGCAGCCGCTCCTCC	0.622000													41	114					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276647	152276647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152276647C>T	ENST00000368799.1	-	3	10750	c.10715G>A	c.(10714-10716)aGa>aAa	p.R3572K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3572	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGCCATCTCTTGACTGCTC	0.557000									Ichthyosis				33	455					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57685473	57685473	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:57685473C>T	ENST00000562631.1	+	3	958	c.426C>T	c.(424-426)tcC>tcT	p.S142S	GPR56_ENST00000540164.2_Silent_p.S142S|GPR56_ENST00000379694.4_Intron|GPR56_ENST00000388812.4_Silent_p.S142S|GPR56_ENST00000388813.5_Silent_p.S142S|GPR56_ENST00000379696.3_Silent_p.S142S|GPR56_ENST00000568909.1_Silent_p.S142S|GPR56_ENST00000562558.1_Silent_p.S142S|GPR56_ENST00000564912.1_3'UTR|GPR56_ENST00000568908.1_Silent_p.S142S|GPR56_ENST00000456916.1_Silent_p.S142S|GPR56_ENST00000538815.1_Silent_p.S142S|GPR56_ENST00000567835.1_Silent_p.S142S|GPR56_ENST00000544297.1_5'UTR			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	142					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						CTGTCACCTCCTGGTGGAGCC	0.602000													8	49					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148055131	148055131	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:148055131T>A	ENST00000370460.2	+	16	3877	c.3398T>A	c.(3397-3399)cTc>cAc	p.L1133H	AFF2_ENST00000286437.5_Missense_Mutation_p.L774H|AFF2_ENST00000370457.5_Missense_Mutation_p.L1098H|AFF2_ENST00000342251.3_Missense_Mutation_p.L1100H	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	1133					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					ACTGTGGAGCTCCTCAGGTGA	0.438000													16	20					0	0	1	0	0
CHRNB3	1142	broad.mit.edu	37	8	42587021	42587021	+	Missense_Mutation	SNP	G	G	A	rs78866303	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42587021G>A	ENST00000289957.2	+	5	699	c.571G>A	c.(571-573)Gac>Aac	p.D191N		NM_000749.3	NP_000740.1	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta 3 (neuronal)	191					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			endometrium(4)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TGAAAATGTCGACAGAAAAGA	0.463000													16	70					0	0	1	0	0
CTAG2	30848	broad.mit.edu	37	X	153880692	153880692	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153880692C>T	ENST00000247306.4	-	2	546	c.483G>A	c.(481-483)gaG>gaA	p.E161E	CTAG2_ENST00000369585.3_Intron	NM_020994.3	NP_066274.1	O75638	CTAG2_HUMAN	cancer/testis antigen 2	161						centrosome				central_nervous_system(1)|endometrium(1)|lung(6)|ovary(1)|pancreas(1)	10	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTTTCTGCCCCTCCGGGGAGG	0.627000													49	48					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57602219	57602219	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57602219T>C	ENST00000371236.2	-	4	566	c.303A>G	c.(301-303)acA>acG	p.T101T	DAB1_ENST00000420954.2_Silent_p.T101T|DAB1_ENST00000439789.2_Silent_p.T101T|DAB1_ENST00000371234.4_Silent_p.T101T|DAB1_ENST00000371231.1_Silent_p.T101T|DAB1_ENST00000414851.2_Silent_p.T101T|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371230.1_Silent_p.T101T			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	101	PID.				cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TACTTACCCCTGTCTTCTCAT	0.408000													8	53					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891895	5891895	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:5891895G>A	ENST00000581347.1	-	3	813	c.168C>T	c.(166-168)gcC>gcT	p.A56A	TMEM200C_ENST00000383490.2_Silent_p.A56A|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	56						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						TCCCACAGAGGGCGATGAGCC	0.622000													9	30					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6678411	6678411	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:6678411G>A	ENST00000245907.6	-	39	4778	c.4686C>T	c.(4684-4686)atC>atT	p.I1562I	C3_ENST00000599668.1_5'UTR	NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1562	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CAATGGCCATGATGTACTCGT	0.577000													11	26					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47173598	47173598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:47173598C>T	ENST00000447411.1	-	8	829	c.623G>A	c.(622-624)gGa>gAa	p.G208E	SLC38A4_ENST00000266579.4_Missense_Mutation_p.G208E	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	208					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					AAGAATAATTCCAACAGACAC	0.303000													17	48					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71036318	71036318	+	Silent	SNP	C	C	T	rs144325682		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:71036318C>T	ENST00000333538.5	+	6	1645	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	337	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGAAGTTCTTCGGTGAAATTG	0.507000													29	87					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10447742	10447742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:10447742G>A	ENST00000326756.3	-	3	649	c.211C>T	c.(211-213)Ctt>Ttt	p.L71F		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						AAATCTTGAAGAGAGATCTTG	0.463000													53	151					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15928546	15928546	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:15928546C>T	ENST00000504595.1	+	3	1156	c.675C>T	c.(673-675)atC>atT	p.I225I	FBXL7_ENST00000510662.1_Silent_p.I178I|FBXL7_ENST00000329673.7_Silent_p.I213I	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	225					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GTTACAATATCTCCAACGAGG	0.582000													18	59					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107865087	107865087	+	Missense_Mutation	SNP	G	G	A	rs104886363		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:107865087G>A	ENST00000328300.6	+	32	2976	c.2732G>A	c.(2731-2733)gGa>gAa	p.G911E	COL4A5_ENST00000361603.2_Missense_Mutation_p.G911E	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	911	Triple-helical region.		G -> E (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGACCTTTGGGAATTCCTGGC	0.423000									Alport syndrome with Diffuse Leiomyomatosis				6	13					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599804	29599804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29599804G>A	ENST00000431530.3	+	1	1057	c.999G>A	c.(997-999)gaG>gaA	p.E333E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	323						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TTGAACAGGAGGGAAAGGCAG	0.532000													13	37					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60485496	60485496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60485496G>A	ENST00000360469.5	+	9	1295	c.1207G>A	c.(1207-1209)Gaa>Aaa	p.E403K	CDH4_ENST00000543233.1_Missense_Mutation_p.E329K	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	403	Cadherin 3.				adherens junction organization|cell junction assembly		calcium ion binding	p.E403K(1)		NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGAGGTCCCCGAAAACCGCGT	0.522000													16	35					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25023490	25023490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25023490C>T	ENST00000400382.1	+	12	1867	c.1112C>T	c.(1111-1113)cCc>cTc	p.P371L	GGT1_ENST00000400380.1_Missense_Mutation_p.P371L|GGT1_ENST00000404532.1_Missense_Mutation_p.P27L|GGT1_ENST00000466310.1_3'UTR|GGT1_ENST00000400383.1_Missense_Mutation_p.P371L|GGT1_ENST00000248923.4_Missense_Mutation_p.P371L|GGT1_ENST00000403838.1_Missense_Mutation_p.P27L|GGT1_ENST00000406383.2_Missense_Mutation_p.P371L|GGT1_ENST00000404920.1_Missense_Mutation_p.P27L|GGT1_ENST00000404223.1_Missense_Mutation_p.P27L|GGT1_ENST00000401885.1_Missense_Mutation_p.P27L			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	371					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	TACTACAAGCCCGAGTTCTAC	0.617000													17	25					0	0	1	0	0
SPRY4	81848	broad.mit.edu	37	5	141694698	141694698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:141694698G>A	ENST00000344120.4	-	3	231	c.45C>T	c.(43-45)tcC>tcT	p.S15S	SPRY4_ENST00000503582.1_5'UTR|SPRY4_ENST00000434127.2_5'UTR	NM_030964.3	NP_112226.2	Q9C004	SPY4_HUMAN	sprouty homolog 4 (Drosophila)	0					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(1)	18		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACTGTACGGAGAAACAGG	0.612000									Testicular Cancer, Familial Clustering of				6	21					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640680	104640680	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104640680G>A	ENST00000304883.2	-	1	293	c.153C>T	c.(151-153)ctC>ctT	p.L51L		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	51						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGGAGGAGGAGAGGTTGCCAG	0.697000													26	42					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55202068	55202068	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:55202068C>A	ENST00000396834.1	+	11	1643	c.1147C>A	c.(1147-1149)Ctt>Att	p.L383I	IL31RA_ENST00000396836.2_Missense_Mutation_p.L402I|IL31RA_ENST00000490985.1_Missense_Mutation_p.L260I|IL31RA_ENST00000354961.4_Missense_Mutation_p.L383I|IL31RA_ENST00000359040.5_Missense_Mutation_p.L402I|IL31RA_ENST00000297015.3_Missense_Mutation_p.L260I|IL31RA_ENST00000447346.2_Missense_Mutation_p.L402I	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	370	Fibronectin type-III 4.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GCCCACCACCCTTTCCTGGGA	0.537000													19	46					2.70639e-06	2.71188e-06	1	1	0
COL5A3	50509	broad.mit.edu	37	19	10077009	10077009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10077009G>A	ENST00000264828.3	-	64	4848	c.4763C>T	c.(4762-4764)cCc>cTc	p.P1588L		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1588	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CTTCTTGTCGGGATAGAGGCA	0.592000													20	43					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73096880	73096880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73096880C>T	ENST00000450736.2	+	4	1537	c.1122C>T	c.(1120-1122)ggC>ggT	p.G374G	SLC16A5_ENST00000580123.1_Silent_p.G374G|SLC16A5_ENST00000329783.4_Silent_p.G374G|SLC16A5_ENST00000538213.2_Silent_p.G414G			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	374					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	TCCTGGACGGCCTTGCTTTCC	0.592000													11	11					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34698120	34698120	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34698120T>A	ENST00000360581.1	+	1	224	c.96T>A	c.(94-96)ttT>ttA	p.F32L	AC005493.1_ENST00000399077.1_Intron|NPSR1_ENST00000359791.1_Missense_Mutation_p.F32L|NPSR1_ENST00000381553.3_Missense_Mutation_p.F32L|NPSR1_ENST00000381539.3_Missense_Mutation_p.F32L|NPSR1_ENST00000465305.1_Missense_Mutation_p.F32L|NPSR1-AS1_ENST00000419766.1_RNA|NPSR1_ENST00000381542.1_Missense_Mutation_p.F32L|NPSR1_ENST00000531252.1_Missense_Mutation_p.F32L	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	32						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CAGTGACTTTTACTGAAGTGG	0.498000													20	71					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8175746	8175746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8175746C>T	ENST00000600128.1	-	34	4730	c.4316G>A	c.(4315-4317)gGg>gAg	p.G1439E	FBN3_ENST00000601739.1_Missense_Mutation_p.G1439E|FBN3_ENST00000270509.2_Missense_Mutation_p.G1439E			Q75N90	FBN3_HUMAN	fibrillin 3	1439	EGF-like 22; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTTGCCACCCCCTCGGTCCAG	0.602000													10	144					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216288081	216288081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:216288081G>A	ENST00000354785.4	-	9	1754	c.1385C>T	c.(1384-1386)cCc>cTc	p.P462L	FN1_ENST00000443816.1_Missense_Mutation_p.P462L|FN1_ENST00000357009.2_Missense_Mutation_p.P462L|FN1_ENST00000323926.6_Missense_Mutation_p.P462L|FN1_ENST00000446046.1_Missense_Mutation_p.P462L|FN1_ENST00000426059.1_Missense_Mutation_p.P462L|FN1_ENST00000356005.4_Missense_Mutation_p.P462L|FN1_ENST00000432072.2_Missense_Mutation_p.P462L|FN1_ENST00000336916.4_Missense_Mutation_p.P462L|FN1_ENST00000345488.5_Missense_Mutation_p.P462L|FN1_ENST00000346544.3_Missense_Mutation_p.P462L|FN1_ENST00000421182.1_Missense_Mutation_p.P462L|FN1_ENST00000359671.1_Missense_Mutation_p.P462L|FN1_ENST00000357867.4_Missense_Mutation_p.P462L			P02751	FINC_HUMAN	fibronectin 1	462	Collagen-binding.|Fibronectin type-II 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCAGCCATGGGGCAGAACCC	0.458000													34	54					0	0	1	0	0
MPP3	4356	broad.mit.edu	37	17	41907410	41907410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:41907410G>A	ENST00000398393.1	-	4	623	c.363C>T	c.(361-363)tcC>tcT	p.S121S	MPP3_ENST00000398389.4_Silent_p.S96S			Q13368	MPP3_HUMAN	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	96					signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		GGTGCGGGGTGGACAGCAGCT	0.637000													10	23					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116205144	116205144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116205144C>T	ENST00000533213.2	-	16	1875	c.1574G>A	c.(1573-1575)aGa>aAa	p.R525K	ABLIM1_ENST00000369253.2_Missense_Mutation_p.R208K|ABLIM1_ENST00000369266.3_Missense_Mutation_p.R262K|ABLIM1_ENST00000277895.5_Missense_Mutation_p.R585K|ABLIM1_ENST00000392952.3_Missense_Mutation_p.R262K|ABLIM1_ENST00000369252.4_Missense_Mutation_p.R525K			O14639	ABLM1_HUMAN	actin binding LIM protein 1	585					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		GCCACTAGATCTGCGTTTCAT	0.458000													61	135					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44610887	44610887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44610887C>T	ENST00000336976.6	+	6	828	c.574C>T	c.(574-576)Cgt>Tgt	p.R192C	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	192					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				CTCAGCCCTTCGTATTCATCA	0.413000													27	248					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60499180	60499180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:60499180G>A	ENST00000371201.3	-	7	1104	c.997C>T	c.(997-999)Cgc>Tgc	p.R333C	C1orf87_ENST00000450089.2_Intron	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	333							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GAGAACGAGCGATCTTCTTTT	0.433000													28	112					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103090189	103090189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:103090189G>A	ENST00000374902.4	-	8	1857	c.1681C>T	c.(1681-1683)Cat>Tat	p.H561Y	TEX10_ENST00000535814.1_Missense_Mutation_p.H564Y	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	561						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		GAGCCAAGATGAGCAAGTTGC	0.403000													19	38					0	0	1	0	0
APOBEC3G	60489	broad.mit.edu	37	22	39477000	39477000	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39477000G>A	ENST00000407997.3	+	3	591	c.234G>A	c.(232-234)agG>agA	p.R78R	APOBEC3G_ENST00000461827.1_3'UTR|APOBEC3G_ENST00000452957.2_Silent_p.R78R	NM_021822.3	NP_068594.1			apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G											central_nervous_system(1)|large_intestine(4)|lung(5)|skin(1)|stomach(1)	12	Melanoma(58;0.04)					GCAAGTGGAGGAAGCTGCATC	0.552000													23	40					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79069905	79069905	+	Missense_Mutation	SNP	C	C	T	rs148218299	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79069905C>T	ENST00000388820.4	-	9	1558	c.1348G>A	c.(1348-1350)Gac>Aac	p.D450N	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	450	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCAGGAGGGTCGTCCAGGCAC	0.652000													14	7					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50295082	50295082	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:50295082C>T	ENST00000320634.3	-	2	136	c.42G>A	c.(40-42)ggG>ggA	p.G14G	FAIM2_ENST00000550890.1_5'UTR	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	14					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						GCCCCTCGGTCCCAGGGGCCT	0.607000													15	60					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110857886	110857886	+	Splice_Site	SNP	C	C	T	rs111267529		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110857886C>T	ENST00000375820.4	-	16	980		c.e16-1		COL4A1_ENST00000543140.1_Splice_Site	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1						angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CGGGTTTGCCCTGTAGAATAA	0.483000													41	175					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146807044	146807044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:146807044G>A	ENST00000508784.1	-	4	1760	c.1533C>T	c.(1531-1533)agC>agT	p.S511S	ZNF827_ENST00000379448.4_Silent_p.S511S|ZNF827_ENST00000513320.1_Silent_p.S161S			Q17R98	ZN827_HUMAN	zinc finger protein 827	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					CCCCTCCCTGGCTAGTCCTCT	0.602000													22	54					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	170145770	170145770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:170145770G>A	ENST00000328939.4	+	2	607	c.70G>A	c.(70-72)Gaa>Aaa	p.E24K	KCNIP1_ENST00000434108.1_Missense_Mutation_p.E24K|KCNIP1_ENST00000390656.4_Missense_Mutation_p.E24K|KCNIP1_ENST00000520740.1_5'UTR|KCNIP1_ENST00000377360.4_Missense_Mutation_p.E33K|KCNIP1_ENST00000411494.1_Missense_Mutation_p.E35K	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	35					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATAAGATTGAAGATGAGCT	0.517000													17	22					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35923030	35923030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:35923030G>A	ENST00000490799.1	-	17	2484	c.2131C>T	c.(2131-2133)Cct>Tct	p.P711S	SLC26A8_ENST00000394602.2_Missense_Mutation_p.P606S|SLC26A8_ENST00000355574.2_Missense_Mutation_p.P711S	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	711	Interaction with RACGAP1.|STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						TCTGAGTAAGGGATGAGTGAT	0.507000													27	63					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160873224	160873224	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160873224C>T	ENST00000283243.7	-	9	1659		c.e9-1		PLA2R1_ENST00000392771.1_Splice_Site	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa						endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						AGTGTCCCTCCTACGGAGAAA	0.378000													17	57					0	0	1	0	0
DENND1B	163486	broad.mit.edu	37	1	197522230	197522230	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197522230G>A	ENST00000235453.4	-	16	1349	c.1072C>T	c.(1072-1074)Cga>Tga	p.R358*	DENND1B_ENST00000367396.3_Nonsense_Mutation_p.R388*|DENND1B_ENST00000400967.2_Nonsense_Mutation_p.R358*			Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B	388	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity	p.R358*(1)|p.R388*(1)|p.R28*(1)		NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						TTTGCCAGTCGACCATCGATA	0.299000													9	75					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6946681	6946681	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6946681C>T	ENST00000251761.8	+	0	1688				LEPREL2_ENST00000396725.2_RNA|LEPREL2_ENST00000606935.1_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						TACTTCTCCCCGGAACGGCCC	0.657000													5	14					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51974720	51974720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:51974720C>T	ENST00000220478.3	+	2	492	c.89C>T	c.(88-90)tCt>tTt	p.S30F	SCG3_ENST00000542355.2_Intron	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	30					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		CTAGACAAATCTCTACATAAT	0.244000													16	37					0	0	1	0	0
FGF21	26291	broad.mit.edu	37	19	49261325	49261325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49261325G>A	ENST00000593756.1	+	4	1050	c.478G>A	c.(478-480)Gga>Aga	p.G160R	FGF21_ENST00000222157.3_Missense_Mutation_p.G160R			Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21	160					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)|cervix(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TGCACCCCGAGGACCAGCTCG	0.687000													10	48					0	0	1	0	0
ESCO2	157570	broad.mit.edu	37	8	27660931	27660931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27660931C>T	ENST00000305188.8	+	11	2020	c.1782C>T	c.(1780-1782)ttC>ttT	p.F594F	ESCO2_ENST00000397418.2_Intron	NM_001017420.2	NP_001017420.1	Q56NI9	ESCO2_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 2	594					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		CCCCTAATTTCCTCGTATATA	0.333000									SC Phocomelia syndrome				26	65					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40719134	40719134	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:40719134C>T	ENST00000454349.2	+	23	5602	c.5391C>T	c.(5389-5391)aaC>aaT	p.N1797N	TNRC6B_ENST00000301923.9_Silent_p.N993N|TNRC6B_ENST00000335727.8_Silent_p.N1687N|TNRC6B_ENST00000402203.1_Silent_p.N993N	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1797					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						GGCCCCCAAACTATTCTTCTA	0.607000													9	23					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90281262	90281262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:90281262G>A	ENST00000405460.2	+	85	18171	c.18075G>A	c.(18073-18075)gtG>gtA	p.V6025V	GPR98_ENST00000425867.2_Silent_p.V1686V	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6025					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTTTGTGGTGATTCTCCTCA	0.438000													8	51					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128342354	128342354	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:128342354G>A	ENST00000389524.4	+	14	1609	c.1554_splice	c.e14-1	p.G519_splice	MYO7B_ENST00000428314.1_Splice_Site_p.G519_splice|MYO7B_ENST00000409816.2_Splice_Site_p.G519_splice			Q6PIF6	MYO7B_HUMAN	myosin VIIB	519	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TTCTTCCAGGGGACAGATCTC	0.567000													31	65					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57358377	57358377	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57358377G>A	ENST00000314922.3	-	1	212	c.136C>T	c.(136-138)Ctg>Ttg	p.L46L	PENK_ENST00000523051.1_Silent_p.L46L|RP11-17A4.2_ENST00000518662.1_RNA|PENK_ENST00000518770.1_Silent_p.L46L|PENK_ENST00000451791.2_Silent_p.L46L	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	46					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			ACACTCACCAGGAAGTTGATG	0.687000													8	91					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59282416	59282416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59282416G>A	ENST00000329328.3	+	1	31	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						CAGAGTGAAAGAATTTACCTT	0.378000													48	111					0	0	1	0	0
DHRS13	147015	broad.mit.edu	37	17	27225649	27225649	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:27225649G>A	ENST00000394901.3	-	4	1186	c.794C>T	c.(793-795)cCt>cTt	p.P265L	DHRS13_ENST00000378895.4_Missense_Mutation_p.P315L|RP11-20B24.4_ENST00000580603.1_RNA|DHRS13_ENST00000426464.2_Missense_Mutation_p.P234L|RP11-20B24.4_ENST00000579187.1_RNA			Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	315						extracellular region	binding|oxidoreductase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	9	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			ATCCTCCCCAGGCCCAAGCCC	0.627000													8	9					0	0	1	0	0
MFSD2A	84879	broad.mit.edu	37	1	40430940	40430940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:40430940C>T	ENST00000372809.5	+	4	593	c.450C>T	c.(448-450)ccC>ccT	p.P150P	MFSD2A_ENST00000420632.2_5'UTR|MFSD2A_ENST00000372811.5_Silent_p.P137P|MFSD2A_ENST00000480630.1_3'UTR	NM_001136493.1	NP_001129965.1	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing 2A	150					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						GGTTCGTGCCCGACTTCCCAC	0.567000													6	100					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32821520	32821520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32821520C>T	ENST00000380250.3	+	48	7385	c.6889C>T	c.(6889-6891)Ctt>Ttt	p.L2297F		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GTCAGCCAGCCTTGTTTTACC	0.408000													36	100					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	108970464	108970464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:108970464C>T	ENST00000276659.5	-	5	1080	c.460G>A	c.(460-462)Gga>Aga	p.G154R	RSPO2_ENST00000378439.2_Missense_Mutation_p.G90R|RSPO2_ENST00000517939.1_Missense_Mutation_p.G87R|RSPO2_ENST00000517781.1_Missense_Mutation_p.G90R	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	154	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CTACAAGTTCCCCATTCGCTC	0.373000													24	65					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367211	107367211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107367211C>T	ENST00000542196.1	-	1	740	c.698G>A	c.(697-699)gGg>gAg	p.G233E		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						TTTGCTTCTCCCCTCGGAAGA	0.413000													25	68					0	0	1	0	0
TM6SF1	53346	broad.mit.edu	37	15	83784673	83784673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83784673C>T	ENST00000322019.9	+	3	547	c.273C>T	c.(271-273)ttC>ttT	p.F91F	TM6SF1_ENST00000565774.1_Silent_p.F91F|TM6SF1_ENST00000564988.1_3'UTR|TM6SF1_ENST00000379386.4_Silent_p.F91F|TM6SF1_ENST00000379390.6_Silent_p.F91F			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	91						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						TTGACGGGTTCATGACACACT	0.433000													22	67					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166167070	166167070	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166167070G>T	ENST00000357398.3	+	7	1225	c.935G>T	c.(934-936)aGc>aTc	p.S312I	SCN2A_ENST00000375437.2_Missense_Mutation_p.S312I|SCN2A_ENST00000375427.2_Missense_Mutation_p.S312I|SCN2A_ENST00000283256.6_Missense_Mutation_p.S312I			Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	312					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	AGGACAGTGAGCATATTTAAC	0.284000													17	47					5.35267e-07	5.36609e-07	1	1	0
IFNA21	3452	broad.mit.edu	37	9	21166595	21166595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:21166595G>A	ENST00000380225.1	-	1	64	c.17C>T	c.(16-18)tCt>tTt	p.S6F		NM_002175.2	NP_002166.2	P01568	IFN21_HUMAN	interferon, alpha 21	6					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)	14				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CATCAGTAAAGAAAAGGACAG	0.498000													25	65					0	0	1	0	0
MYLIP	29116	broad.mit.edu	37	6	16141939	16141939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:16141939C>T	ENST00000356840.3	+	3	560	c.362C>T	c.(361-363)gCc>gTc	p.A121V	MYLIP_ENST00000349606.4_5'UTR	NM_013262.3	NP_037394.2	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting protein	121	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GAACTCAGTGCCCTCCTGGCC	0.537000													34	69					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	769423	769423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:769423G>A	ENST00000297440.6	+	2	739	c.719G>A	c.(718-720)gGg>gAg	p.G240E	HEATR2_ENST00000438961.1_3'UTR|HEATR2_ENST00000313147.5_Missense_Mutation_p.G240E	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	240							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		TTTGGCAACGGGAAGTCCGTG	0.572000													18	42					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142723973	142723973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142723973C>T	ENST00000350513.2	-	1	309	c.247G>A	c.(247-249)Gga>Aga	p.G83R		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					AAGAGCAATCCCCAAAGCATC	0.483000													25	55					0	0	1	0	0
OR52E4	390081	broad.mit.edu	37	11	5906301	5906301	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5906301T>A	ENST00000316987.2	+	1	801	c.779T>A	c.(778-780)tTt>tAt	p.F260Y		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTTTTTTCTTTTATGACACAT	0.423000													59	129					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187172751	187172751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187172751C>T	ENST00000264690.6	+	9	1166	c.979C>T	c.(979-981)Cgc>Tgc	p.R327C	KLKB1_ENST00000513864.1_Missense_Mutation_p.R327C	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	327	Apple 4.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		AAAGATGATTCGCTGTCAGTT	0.353000													38	87					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12725999	12725999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12725999C>T	ENST00000376221.1	+	4	477	c.477C>T	c.(475-477)tcC>tcT	p.S159S		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	159						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		ACCACCATTCCCCTGCCCTTT	0.522000													10	103					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124745472	124745472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124745472C>T	ENST00000397801.1	+	15	2504	c.2312C>T	c.(2311-2313)cCc>cTc	p.P771L	ROBO3_ENST00000538940.1_Missense_Mutation_p.P749L	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	771	Fibronectin type-III 3.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CCCAGTGGCCCCCCACAGGGA	0.612000													6	26					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165984293	165984293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:165984293C>T	ENST00000360093.3	-	18	3732	c.3241G>A	c.(3241-3243)Gaa>Aaa	p.E1081K	SCN3A_ENST00000283254.7_Missense_Mutation_p.E1081K|SCN3A_ENST00000409101.3_Missense_Mutation_p.E1032K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1081						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ACGTATTTTTCAACACTGCTT	0.393000													24	62					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827110	96827110	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96827110G>A	ENST00000371270.3	-	3	430	c.336C>T	c.(334-336)atC>atT	p.I112I	CYP2C8_ENST00000535898.1_Silent_p.I10I|CYP2C8_ENST00000539050.1_Silent_p.I26I	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	112					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TGCTGGAAATGATTCCTAATA	0.488000													17	51					0	0	1	0	0
TOMM40L	84134	broad.mit.edu	37	1	161196322	161196322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:161196322C>T	ENST00000367988.3	+	2	312	c.43C>T	c.(43-45)Cgc>Tgc	p.R15C	TOMM40L_ENST00000474486.1_3'UTR|TOMM40L_ENST00000367987.1_Missense_Mutation_p.R15C|TOMM40L_ENST00000545897.1_Missense_Mutation_p.R15C	NM_032174.4	NP_115550.2	Q969M1	TM40L_HUMAN	translocase of outer mitochondrial membrane 40 homolog (yeast)-like	15					protein transport	mitochondrial outer membrane|pore complex	porin activity|voltage-gated anion channel activity			large_intestine(2)|liver(4)|lung(4)	10	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GACTTTGCCCCGCCGGAGCCC	0.602000													12	44					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64331852	64331852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:64331852G>A	ENST00000301891.4	+	5	1268	c.894G>A	c.(892-894)aaG>aaA	p.K298K	SLC22A11_ENST00000377585.3_Silent_p.K298K|SLC22A11_ENST00000377581.3_Silent_p.K298K|SLC22A11_ENST00000490834.1_Intron	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	298					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	AGCTCAGAAAGGTGGCCAGGA	0.562000													20	49					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35033608	35033608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35033608C>T	ENST00000231420.6	-	6	832	c.632G>A	c.(631-633)gGg>gAg	p.G211E		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	211					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CTTGTAGGTCCCTACGTTTGT	0.483000													18	56					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93615517	93615517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:93615517G>A	ENST00000394236.3	-	9	1184	c.868C>T	c.(868-870)Ccc>Tcc	p.P290S	PROS1_ENST00000407433.1_Missense_Mutation_p.P159S	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	290					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	AGGTTCAAGGGAAGGCACACT	0.368000													36	166					0	0	1	0	0
TRIM40	135644	broad.mit.edu	37	6	30104940	30104940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:30104940G>A	ENST00000396581.1	+	2	513	c.127G>A	c.(127-129)Gag>Aag	p.E43K	TRIM40_ENST00000307859.4_Missense_Mutation_p.E43K|TRIM40_ENST00000489892.1_3'UTR|TRIM40_ENST00000376724.2_Missense_Mutation_p.E43K			Q6P9F5	TRI40_HUMAN	tripartite motif containing 40	43						intracellular	zinc ion binding			ovary(1)	1						ACAGCATGTGGAGAAGGCCTC	0.612000													16	47					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48327813	48327813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:48327813C>T	ENST00000428869.2	-	7	749	c.491G>A	c.(490-492)gGg>gAg	p.G164E	MRO_ENST00000436348.2_Missense_Mutation_p.G178E|MRO_ENST00000587291.1_5'UTR|MRO_ENST00000256425.2_Missense_Mutation_p.G164E|MRO_ENST00000398439.3_Missense_Mutation_p.G164E|MRO_ENST00000588444.1_Intron|MRO_ENST00000431965.2_Intron			Q9BYG7	MSTRO_HUMAN	maestro	164						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		CCATTTCCTCCCGGCAAAGGC	0.468000													69	134					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49381496	49381496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:49381496G>A	ENST00000406846.2	-	1	180	c.61C>T	c.(61-63)Cgg>Tgg	p.R21W	FSHR_ENST00000346173.3_Missense_Mutation_p.R21W|FSHR_ENST00000304421.4_Missense_Mutation_p.R21W	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	21	LRRNT.				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGACAGATCCGATGATGACAT	0.493000									Gonadal Dysgenesis, 46 XX				18	36					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55652961	55652961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55652961G>A	ENST00000449290.2	+	2	149	c.57G>A	c.(55-57)atG>atA	p.M19I		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	19						intracellular	zinc ion binding										CCATCTGCATGAACTACTTCC	0.502000													41	99					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40979312	40979312	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:40979312G>A	ENST00000373198.3	-	11	2056	c.1821C>T	c.(1819-1821)atC>atT	p.I607I	PTPRT_ENST00000373187.1_Silent_p.I607I|PTPRT_ENST00000373193.3_Silent_p.I607I|PTPRT_ENST00000373201.1_Silent_p.I607I|PTPRT_ENST00000373184.1_Silent_p.I607I|PTPRT_ENST00000356100.2_Silent_p.I607I|PTPRT_ENST00000373190.1_Silent_p.I607I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	607	Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCATCACTGTGATGGTCGTGT	0.532000													44	105					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141007	143141007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143141007C>T	ENST00000332690.1	+	1	462	c.462C>T	c.(460-462)ttC>ttT	p.F154F	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	154					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					TCTCCAGCTTCACCACCATTC	0.463000													66	161					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106124535	106124535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106124535G>A	ENST00000369704.3	+	4	619	c.485G>A	c.(484-486)aGa>aAa	p.R162K	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	162										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ACAAAGGAGAGAGACCAGCTC	0.458000													22	60					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42796998	42796998	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42796998C>T	ENST00000572681.2	+	15	6248	c.6180C>T	c.(6178-6180)ttC>ttT	p.F2060F	CIC_ENST00000575354.2_Silent_p.F1152F|CIC_ENST00000160740.3_Silent_p.F1151F			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CTAGCCCTTTCCCCAGCGCCA	0.632000			"""Mis, F, S"""		oligodendroglioma								15	112					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50488621	50488621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:50488621C>T	ENST00000266182.6	-	2	106	c.107G>A	c.(106-108)cGa>cAa	p.R36Q	TTLL8_ENST00000477219.1_5'UTR|TTLL8_ENST00000440475.1_Missense_Mutation_p.R36Q					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GCCCTTCCTTCGCAGAGCGGC	0.493000													6	14					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793740	17793740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17793740G>A	ENST00000379472.3	+	2	1129	c.1099G>A	c.(1099-1101)Gag>Aag	p.E367K	KCNC1_ENST00000265969.6_Missense_Mutation_p.E367K	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	367						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CTACTACGCCGAGAGGATAGG	0.607000													16	51					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307514	140307514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140307514C>T	ENST00000253807.2	+	1	1037	c.1037C>T	c.(1036-1038)tCg>tTg	p.S346L	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.S346L|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGACTCTTTCGAACCCAGTA	0.517000													9	147					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109780861	109780861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:109780861C>T	ENST00000399132.1	-	24	1801	c.1271G>A	c.(1270-1272)gGa>gAa	p.G424E	COL25A1_ENST00000399126.1_Missense_Mutation_p.G424E|COL25A1_ENST00000399127.1_Missense_Mutation_p.G405E	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	424	Collagen-like 5.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTCAGTGGCTCCTTGATCCCC	0.507000													12	35					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065679	55065679	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55065679G>A	ENST00000526016.1	-	0	29					NR_038174.2																						ACTGGGTCTAGGAAGTAGTTC	0.473000													49	93					0	0	1	0	0
ICAM5	7087	broad.mit.edu	37	19	10405169	10405169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10405169C>T	ENST00000221980.4	+	9	2146	c.2083C>T	c.(2083-2085)Cgc>Tgc	p.R695C		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	695	Ig-like C2-type 8.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CGCCCGGGGTCGCCCTTCCCC	0.677000													9	27					0	0	1	0	0
DRAXIN	374946	broad.mit.edu	37	1	11766499	11766499	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11766499C>T	ENST00000294485.5	+	2	319	c.184C>T	c.(184-186)Ccg>Tcg	p.P62S		NM_198545.3	NP_940947.3			dorsal inhibitory axon guidance protein																		CCGGCGGGGCCCGGGCAAGAA	0.721000													9	15					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52520529	52520529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:52520529G>A	ENST00000242839.4	-	13	3107	c.2951C>T	c.(2950-2952)cCc>cTc	p.P984L	ATP7B_ENST00000400366.3_Missense_Mutation_p.P873L|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000417240.2_Missense_Mutation_p.P256L|ATP7B_ENST00000400370.3_Missense_Mutation_p.P554L|ATP7B_ENST00000418097.2_Intron|ATP7B_ENST00000448424.2_Missense_Mutation_p.P906L|ATP7B_ENST00000344297.5_Missense_Mutation_p.P777L	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	984					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CAGGGAGCAGGGGCAGGCAAT	0.622000									Wilson disease				5	36					0	0	1	0	0
ZNF670	93474	broad.mit.edu	37	1	247202116	247202116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247202116G>A	ENST00000366503.2	-	3	345	c.187C>T	c.(187-189)Cta>Tta	p.L63L		NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			AATTACCTTAGATTTCTCCCA	0.328000													11	59					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6262747	6262747	+	Missense_Mutation	SNP	C	C	T	rs141400949	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6262747C>T	ENST00000379936.2	+	5	1119	c.1004C>T	c.(1003-1005)gCt>gTt	p.A335V	CNGA4_ENST00000533426.1_Missense_Mutation_p.A104V	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	335					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGAAGTGGCTGTGTCTGTG	0.577000													37	86					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91811697	91811697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91811697C>T	ENST00000394232.1	+	9	1705	c.1235C>T	c.(1234-1236)cCt>cTt	p.P412L	SV2B_ENST00000545111.2_Missense_Mutation_p.P261L|SV2B_ENST00000330276.4_Missense_Mutation_p.P412L	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	412					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GTTTGGTTTCCTGATATGATC	0.418000													53	172					0	0	1	0	0
ENTPD2	954	broad.mit.edu	37	9	139945765	139945765	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139945765G>T	ENST00000355097.2	-	4	491	c.444C>A	c.(442-444)acC>acA	p.T148T	ENTPD2_ENST00000312665.5_Silent_p.T148T	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	148						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGGGGTACTGGGTCAGTGTGT	0.582000													24	60					3.73988e-18	3.76167e-18	1	1	0
SLITRK3	22865	broad.mit.edu	37	3	164906683	164906683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164906683G>A	ENST00000475390.1	-	2	2379	c.1936C>T	c.(1936-1938)Cct>Tct	p.P646S	SLITRK3_ENST00000241274.3_Missense_Mutation_p.P646S			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	646						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CCCCCAGGAGGAGAAAACTCA	0.532000										HNSCC(40;0.11)			10	27					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26802488	26802488	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26802488G>A	ENST00000376236.4	+	8	1167	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	238	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TGAAGACCATGAAAATGTTGT	0.338000													25	58					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134179613	134179613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:134179613G>A	ENST00000431683.2	+	11	1055	c.1055G>A	c.(1054-1056)gGg>gAg	p.G352E		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	352					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TTCATGAACGGGGCCACATAT	0.483000													6	18					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129664305	129664305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:129664305G>A	ENST00000358303.4	-	7	902	c.818C>T	c.(817-819)tCg>tTg	p.S273L	RP11-306G20.1_ENST00000587038.1_RNA|ZC3HC1_ENST00000360708.5_Missense_Mutation_p.S273L|RP11-306G20.1_ENST00000480018.1_RNA|ZC3HC1_ENST00000311873.5_Missense_Mutation_p.S252L|ZC3HC1_ENST00000481503.1_Intron	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	273					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					CATACATTGCGAACATGTTAT	0.468000													17	33					0	0	1	0	0
CHST13	166012	broad.mit.edu	37	3	126261284	126261284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126261284G>A	ENST00000319340.2	+	3	939	c.889G>A	c.(889-891)Gcc>Acc	p.A297T		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	297					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		gccccggggagccgccgccTC	0.706000													4	8					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129276019	129276019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129276019G>A	ENST00000324093.4	-	34	5671	c.5493C>T	c.(5491-5493)taC>taT	p.Y1831Y	PLXND1_ENST00000393239.1_3'UTR|PLXND1_ENST00000504689.1_5'UTR	NM_015103.2	NP_055918.2	Q9Y4D7	PLXD1_HUMAN	plexin D1	1831					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CGATCTTCCGGTACTCAGGAA	0.572000													29	72					0	0	1	0	0
LMO3	55885	broad.mit.edu	37	12	16757809	16757809	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:16757809C>T	ENST00000261169.6	-	1	272	c.15G>A	c.(13-15)gaG>gaA	p.E5E	LMO3_ENST00000541295.1_Intron|LMO3_ENST00000540848.1_Intron|LMO3_ENST00000540445.1_Intron|LMO3_ENST00000537304.1_Intron|LMO3_ENST00000535535.1_Intron|LMO3_ENST00000534946.1_Intron|LMO3_ENST00000537568.1_Intron|LMO3_ENST00000447609.1_Intron|LMO3_ENST00000354662.1_Intron|LMO3_ENST00000441439.2_Intron|LMO3_ENST00000541846.1_Intron|LMO3_ENST00000320122.6_5'UTR			Q8TAP4	LMO3_HUMAN	LIM domain only 3 (rhombotin-like 2)	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent		zinc ion binding			endometrium(2)|large_intestine(2)|skin(1)	5		Hepatocellular(102;0.244)				CAAAACTTTTCTCCTTTTTCT	0.478000													34	92					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566086	5566086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5566086G>A	ENST00000322653.4	-	1	693	c.668C>T	c.(667-669)gCt>gTt	p.A223V	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTAGGAAACAGCAATGAGAAT	0.507000													21	41					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71825460	71825460	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:71825460G>A	ENST00000373545.3	-	23	2877	c.2439C>T	c.(2437-2439)ccC>ccT	p.P813P	PHKA1_ENST00000541944.1_Silent_p.P813P|PHKA1_ENST00000373539.3_Silent_p.P872P|PHKA1_ENST00000339490.3_Silent_p.P872P|PHKA1_ENST00000373542.4_Silent_p.P872P			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	872	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					GCGCCTCATAGGGCAGAGGTC	0.388000													15	17					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170720368	170720368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:170720368G>A	ENST00000314251.3	-	8	1144	c.1065C>T	c.(1063-1065)gtC>gtT	p.V355V	SLC2A2_ENST00000382808.4_Silent_p.V236V	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	355					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GACTTACAGAGACAGCAGTGA	0.428000													12	32					0	0	1	0	0
F12	2161	broad.mit.edu	37	5	176831610	176831610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176831610C>T	ENST00000253496.3	-	8	738	c.690G>A	c.(688-690)agG>agA	p.R230R		NM_000505.3	NP_000496.2	P00748	FA12_HUMAN	coagulation factor XII (Hageman factor)	230	Kringle.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAGCGTGGTCCTGGCCAGGC	0.701000									Hereditary Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	12					0	0	1	0	0
OR8K1	390157	broad.mit.edu	37	11	56114291	56114291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56114291G>A	ENST00000279783.2	+	1	871	c.777G>A	c.(775-777)ggG>ggA	p.G259G		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TGTTCTATGGGACATTGTTAT	0.408000										HNSCC(65;0.19)			12	90					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718804	140718804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140718804G>A	ENST00000394576.2	+	1	266	c.266G>A	c.(265-267)aGg>aAg	p.R89K	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCGAACAGGATAGACCGG	0.547000													20	103					0	0	1	0	0
IGLV3-19	28797	broad.mit.edu	37	22	23063518	23063518	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:23063518G>A	ENST00000390309.2	+	0	265																											GGCCCTCAGGGATCCCAGACC	0.532000													23	53					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101748028	101748028	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:101748028C>T	ENST00000251127.6	-	28	3247	c.3166G>A	c.(3166-3168)Gat>Aat	p.D1056N		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1056						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCATTGCAATCTTCCTAAAGT	0.388000													21	60					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23208684	23208684	+	Missense_Mutation	SNP	C	C	T	rs141248272		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23208684C>T	ENST00000300061.2	+	6	1156	c.1013C>T	c.(1012-1014)cCc>cTc	p.P338L	CTC-391G2.1_ENST00000563471.1_RNA	NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	338					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding	p.P338L(1)		NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GATGAGTATCCCTTCGTCGAA	0.468000													12	56					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684479	100684479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100684479C>T	ENST00000306151.4	+	3	9846	c.9782C>T	c.(9781-9783)tCa>tTa	p.S3261L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3261	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCAGTTCATCTCCTCCC	0.527000													214	469					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105920842	105920842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105920842C>T	ENST00000357060.3	-	27	3608	c.3493G>A	c.(3493-3495)Gag>Aag	p.E1165K	WDR96_ENST00000428666.1_Missense_Mutation_p.E1166K	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1165										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						ACTTTTTTCTCATAATCTTTG	0.333000													12	33					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267481	71267481	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:71267481G>A	ENST00000554752.2	-	2	722	c.723C>T	c.(721-723)atC>atT	p.I241I	MAP3K9_ENST00000555993.2_Silent_p.I241I|MAP3K9_ENST00000381250.4_Silent_p.I241I			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	241	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		AATTCACCAGGATGTCTGGGG	0.502000													13	89					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45295394	45295394	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:45295394G>A	ENST00000447098.2	-	8	986	c.975C>T	c.(973-975)ccC>ccT	p.P325P	PTCH2_ENST00000372192.3_Silent_p.P325P	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	325					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					ACAGCTGGCGGGGACTCATCA	0.617000									Basal Cell Nevus syndrome				24	51					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192053205	192053205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:192053205C>T	ENST00000454309.2	-	3	1184	c.359G>A	c.(358-360)gGa>gAa	p.G120E	FGF12_ENST00000430714.1_Missense_Mutation_p.G21E|FGF12_ENST00000450716.1_Missense_Mutation_p.G58E|FGF12_ENST00000264730.3_Missense_Mutation_p.G58E|FGF12_ENST00000445105.1_Missense_Mutation_p.G58E	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	120					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		AGCCTTCACTCCTTGGATGGC	0.458000													33	84					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538598	4538598	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4538598G>A	ENST00000306390.6	-	2	858	c.398C>T	c.(397-399)cCg>cTg	p.P133L	LRG1_ENST00000586883.1_5'UTR|CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	133			P -> S (in dbSNP:rs966384).			extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGAGGCCCGGGGGCAGCCC	0.632000													23	46					0	0	1	0	0
TRBV6-1	28606	broad.mit.edu	37	7	142028450	142028450	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142028450C>T	ENST00000390353.2	+	0	241																											AGGCATGGGACTGAGGCTGAT	0.488000													45	190					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63141473	63141473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63141473G>A	ENST00000279178.3	+	4	1018	c.769G>A	c.(769-771)Gac>Aac	p.D257N	SLC22A9_ENST00000310969.4_Missense_Mutation_p.R205K	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	257					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						TGCCATTCGAGACTGGCATAT	0.458000													8	39					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7723933	7723933	+	Silent	SNP	C	C	T	rs141193119		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:7723933C>T	ENST00000303635.7	+	9	1533	c.1326C>T	c.(1324-1326)ttC>ttT	p.F442F	CAMTA1_ENST00000439411.2_Silent_p.F442F	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	442					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCCACAAGTTCGCCTTTCCCA	0.652000			T	WWTR1	epitheliod hemangioendothelioma								21	59					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322479	55322479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55322479G>A	ENST00000314644.2	+	1	697	c.697G>A	c.(697-699)Gac>Aac	p.D233N		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CTTTATGTGTGACTTGTACCC	0.458000										HNSCC(20;0.049)			10	40					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3211823	3211823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3211823G>A	ENST00000380059.3	-	9	1244	c.1143C>T	c.(1141-1143)ttC>ttT	p.F381F	SLC4A11_ENST00000380056.3_Silent_p.F354F|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Silent_p.F338F	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	354	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						GGTACAAGGGGAACCTGCGTG	0.602000													41	145					0	0	1	0	0
SHF	90525	broad.mit.edu	37	15	45491118	45491118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:45491118G>A	ENST00000290894.8	-	2	649	c.155C>T	c.(154-156)cCc>cTc	p.P52L	CTD-2651B20.7_ENST00000568314.1_RNA|RP11-519G16.2_ENST00000560034.1_RNA|SHF_ENST00000318390.6_Missense_Mutation_p.P109L	NM_138356.2	NP_612365.2	B3KTY1	B3KTY1_HUMAN	Src homology 2 domain containing F	52										endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(2)	12		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		GGAGTTTAGGGGAGACGGCGT	0.602000											OREG0023105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	37					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046763	73046763	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:73046763C>T	ENST00000604411.1	+	0	34724				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AGCCTTGAGACTTCCATCCAA	0.488000													27	19					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87040294	87040294	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87040294G>A	ENST00000370563.3	+	10	1581	c.1539G>A	c.(1537-1539)gtG>gtA	p.V513V	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	513						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		ATAGTACAGTGGGAAAGGACA	0.393000													26	63					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49699234	49699234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:49699234C>T	ENST00000303221.5	-	6	870	c.655G>A	c.(655-657)Gaa>Aaa	p.E219K	EMB_ENST00000514111.1_Missense_Mutation_p.E169K|EMB_ENST00000506190.1_5'UTR|EMB_ENST00000508934.1_Missense_Mutation_p.E165K	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	219	Ig-like V-type 2.					integral to membrane		p.E219K(1)		breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				AGCTTTGTTTCGTTAGCATAT	0.378000													10	65					0	0	1	0	0
RAD54L	8438	broad.mit.edu	37	1	46733247	46733247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:46733247C>T	ENST00000371975.4	+	9	1682	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	RAD54L_ENST00000442598.1_Silent_p.F336F	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	336	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		TTGAGTATTTCAGCTTGGTAC	0.493000								Direct reversal of damage;Homologous recombination					31	49					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50813008	50813008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50813008C>T	ENST00000440075.2	+	43	6119	c.6072C>T	c.(6070-6072)tcC>tcT	p.S2024S	MYH14_ENST00000425460.1_Silent_p.S1991S|MYH14_ENST00000262269.8_Silent_p.S2024S|MYH14_ENST00000376970.2_Silent_p.S2016S|MYH14_ENST00000598205.1_Silent_p.S1991S|MYH14_ENST00000596571.1_Silent_p.S1983S|MYH14_ENST00000601313.1_Silent_p.S2024S			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1983					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CTGGGCCATCCCCGGAGCCTG	0.682000													5	5					0	0	1	0	0
FCGRT	2217	broad.mit.edu	37	19	50017667	50017667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50017667C>T	ENST00000221466.5	+	4	1011	c.525C>T	c.(523-525)ctC>ctT	p.L175L	FCGRT_ENST00000599988.1_Intron|FCGRT_ENST00000594823.1_3'UTR|FCGRT_ENST00000596975.1_Intron|FCGRT_ENST00000426395.3_Silent_p.L175L	NM_001136019.2	NP_001129491.1	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	175	Alpha-2.				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			endometrium(3)|kidney(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	9		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		ACAAGGAGCTCACCTTCCTGC	0.667000													7	28					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219888004	219888004	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219888004C>T	ENST00000341552.5	-	16	2828	c.2745G>A	c.(2743-2745)tgG>tgA	p.W915*	CCDC108_ENST00000453220.1_Nonsense_Mutation_p.W915*|CCDC108_ENST00000441968.1_Nonsense_Mutation_p.W915*	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	915	MSP.					integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGAGACCCTCCACTCGAACT	0.632000													5	20					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88119601	88119601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:88119601G>A	ENST00000507897.1	+	2	127	c.44G>A	c.(43-45)cGa>cAa	p.R15Q	C6ORF165_ENST00000369562.4_Missense_Mutation_p.R15Q			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	15										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGTATTATACGAGAAATAGGA	0.318000													8	89					0	0	1	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473014	22473014	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22473014C>T	ENST00000557788.2	-	0	256																											TATGGTGACTCGACTCTTGAG	0.577000													40	375					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122261582	122261582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122261582C>T	ENST00000334010.7	-	5	1478	c.1057G>A	c.(1057-1059)Gag>Aag	p.E353K	CADPS2_ENST00000313070.7_Missense_Mutation_p.E353K|CADPS2_ENST00000449022.2_Missense_Mutation_p.E353K|CADPS2_ENST00000412584.2_Missense_Mutation_p.E353K	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	353					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						AGCTGAATCTCATTCTCATCT	0.393000													34	104					0	0	1	0	0
CCL15	6359	broad.mit.edu	37	17	34328476	34328476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34328476G>A	ENST00000354059.4	-	1	608	c.56C>T	c.(55-57)tCc>tTc	p.S19F	RP11-104J23.1_ENST00000590192.1_RNA|CCL15-CCL14_ENST00000481427.2_Missense_Mutation_p.S19F|CCL14_ENST00000536149.1_5'UTR	NM_032965.4	NP_116741.1	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15	19					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity	p.S19Y(1)		large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGGCCTGGGATCCAAGGAC	0.587000													6	40					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34182085	34182085	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34182085G>A	ENST00000373381.4	-	20	3194	c.3018C>T	c.(3016-3018)ttC>ttT	p.F1006F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	966	CUB 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGAAGGTGTGGAAAGTGAAGA	0.542000													8	17					0	0	1	0	0
RANBP10	57610	broad.mit.edu	37	16	67763633	67763633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67763633G>A	ENST00000317506.3	-	9	1212	c.1097C>T	c.(1096-1098)cCc>cTc	p.P366L	RANBP10_ENST00000411657.2_Missense_Mutation_p.P249L|RANBP10_ENST00000602677.1_Missense_Mutation_p.P366L|RANBP10_ENST00000536251.1_Missense_Mutation_p.P137L|RANBP10_ENST00000448631.2_Missense_Mutation_p.P310L	NM_020850.1	NP_065901.1	Q6VN20	RBP10_HUMAN	RAN binding protein 10	366	Ser-rich.									endometrium(5)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		ACTGAGGCTGGGGGAGCCAGG	0.607000													22	71					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113173432	113173432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:113173432C>T	ENST00000401783.2	-	37	6895	c.6559G>A	c.(6559-6561)Gaa>Aaa	p.E2187K	SVEP1_ENST00000374469.1_Missense_Mutation_p.E2164K|SVEP1_ENST00000297826.5_Missense_Mutation_p.E113K	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2187	Sushi 13.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CCTGTGGCTTCGCAGGTGCTC	0.507000													20	69					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100341315	100341315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:100341315C>T	ENST00000334192.4	+	4	565	c.431C>T	c.(430-432)tCg>tTg	p.S144L	EML1_ENST00000556758.1_Intron|EML1_ENST00000327921.9_Missense_Mutation_p.S113L|EML1_ENST00000262233.6_Intron	NM_001008707.1	NP_001008707.1	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	127						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CTGAATAGATCGACACCAAGG	0.378000													25	81					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91726016	91726016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:91726016C>T	ENST00000359028.2	+	41	9980	c.9755C>T	c.(9754-9756)tCa>tTa	p.S3252L	AKAP9_ENST00000356239.3_Missense_Mutation_p.S3248L|AKAP9_ENST00000358100.2_Missense_Mutation_p.S3198L			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3252					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGAAGTTTTCACTTGAGAGT	0.383000			T	BRAF	papillary thyroid								52	24					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090630	9090630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9090630G>A	ENST00000397910.4	-	1	1388	c.1185C>T	c.(1183-1185)acC>acT	p.T395T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	395	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGCCACCAAGGGTACCTGGAC	0.512000													10	44					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52177838	52177838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:52177838G>A	ENST00000282588.6	+	7	1216	c.758G>A	c.(757-759)gGa>gAa	p.G253E		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	253	VWFA.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				ACAGCTCTTGGAATAGACACA	0.378000													5	27					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157667199	157667199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:157667199G>A	ENST00000368184.3	-	6	866	c.575C>T	c.(574-576)cCt>cTt	p.P192L	FCRL3_ENST00000368186.5_Missense_Mutation_p.P192L|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	192	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					TCTCAGCACAGGATGTAGAAA	0.527000													11	68					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25311436	25311436	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25311436C>T	ENST00000354189.5	-	4	377	c.342G>A	c.(340-342)gaG>gaA	p.E114E	CASC1_ENST00000545133.1_Intron|CASC1_ENST00000537577.1_Intron|CASC1_ENST00000395987.3_Silent_p.E56E|CASC1_ENST00000395990.2_Silent_p.E10E|CASC1_ENST00000320267.9_Silent_p.E50E|CASC1_ENST00000557684.1_5'UTR	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	50										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			ATTTTTCTTTCTCAATTCGCT	0.289000													28	34					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48593948	48593948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48593948G>A	ENST00000323776.5	+	2	385	c.223G>A	c.(223-225)Gga>Aga	p.G75R	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.G38R	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	38					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GCGGGCAAAGGGACCTGAACA	0.388000													7	60					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149502729	149502729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:149502729C>T	ENST00000261799.4	-	15	2528	c.2059G>A	c.(2059-2061)Gga>Aga	p.G687R		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	687	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	ACCAGGTCTCCGTAGCGGCAG	0.607000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								21	56					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151339220	151339220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151339220G>A	ENST00000426705.2	-	6	912	c.768C>T	c.(766-768)ttC>ttT	p.F256F	SELENBP1_ENST00000447402.3_Silent_p.F152F|SELENBP1_ENST00000435071.1_Silent_p.F150F|SELENBP1_ENST00000368868.5_Silent_p.F214F	NM_001258289.1	NP_001245218.1	Q13228	SBP1_HUMAN	selenium binding protein 1	214					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCGGGGTTGAAGCCATCTC	0.582000													50	146					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552501	140552501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140552501G>A	ENST00000231137.3	+	1	259	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		29					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCTGGCGCCGAACCGCTTCG	0.517000													25	101					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41957532	41957532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:41957532G>A	ENST00000301831.4	-	8	1202	c.740C>T	c.(739-741)cCt>cTt	p.P247L	ULK4_ENST00000420927.1_Missense_Mutation_p.P247L	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	247	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGAAGCTTTAGGACGAGAAGA	0.274000													29	76					0	0	1	0	0
GOLPH3	64083	broad.mit.edu	37	5	32126481	32126481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:32126481G>A	ENST00000265070.6	-	4	1049	c.734C>T	c.(733-735)gCc>gTc	p.A245V		NM_022130.3	NP_071413.1	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3 (coat-protein)	245					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11						GACGTCCGAGGCATGAGCCAG	0.537000													34	70					0	0	1	0	0
STK26	51765	broad.mit.edu	37	X	131206347	131206347	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:131206347C>T	ENST00000394334.2	+	9	1237	c.984C>T	c.(982-984)acC>acT	p.T328T	MST4_ENST00000496850.1_Silent_p.T266T|MST4_ENST00000394335.2_Silent_p.T251T|MST4_ENST00000354719.6_Silent_p.T328T|MST4_ENST00000481105.1_Silent_p.T350T	NM_016542.3	NP_057626.2	Q9P289	MST4_HUMAN		328					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(192;0.000127)					GCTTTACCACCGTACGAAAGA	0.403000													11	24					0	0	1	0	0
ACTR3C	653857	broad.mit.edu	37	7	149983537	149983537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149983537G>A	ENST00000539352.1	-	5	641	c.390C>T	c.(388-390)atC>atT	p.I130I	ACTR3C_ENST00000252071.4_Silent_p.I130I	NM_001164458.1	NP_001157930.1	Q9C0K3	ARP3C_HUMAN	ARP3 actin-related protein 3 homolog C (yeast)	130					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding										TGATCGCATTGATACCCGTGT	0.413000													15	209					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475124	140475124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140475124G>A	ENST00000194155.4	+	1	898	c.750G>A	c.(748-750)gaG>gaA	p.E250E		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		250	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTCTATGAGGTGCAGATCC	0.522000													9	63					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11562736	11562736	+	Splice_Site	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:11562736C>G	ENST00000294484.6	+	3	1236	c.1096_splice	c.e3-1	p.G366_splice	PTCHD2_ENST00000389575.3_Splice_Site_p.G366_splice	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	366					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCCTTGCAGGCTCCCTGGAGC	0.607000													11	17					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60562913	60562913	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:60562913A>T	ENST00000373886.3	+	15	2096	c.2092A>T	c.(2092-2094)Agt>Tgt	p.S698C	BICC1_ENST00000263103.1_Missense_Mutation_p.S324C	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	698					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						GGCTCCAGGGAGTGAGCGCGC	0.532000													11	61					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110855942	110855942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:110855942C>T	ENST00000375820.4	-	18	1091	c.970G>A	c.(970-972)Gaa>Aaa	p.E324K	COL4A1_ENST00000543140.1_Missense_Mutation_p.E324K	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	324	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGACCTGCTTCACCCTTTTCT	0.458000													35	125					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56663166	56663166	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56663166G>A	ENST00000389934.3	-	18	3183	c.3066C>T	c.(3064-3066)ttC>ttT	p.F1022F	TEX14_ENST00000240361.8_Silent_p.F1028F|TEX14_ENST00000349033.5_Silent_p.F1022F	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	1028						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACTTACTGGTGAAGCTTCCAA	0.517000													36	66					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155498001	155498001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:155498001G>A	ENST00000461783.3	+	12	3686	c.2413G>A	c.(2413-2415)Gac>Aac	p.D805N	TIAM2_ENST00000318981.5_Missense_Mutation_p.D805N|TIAM2_ENST00000367174.2_Missense_Mutation_p.D181N|TIAM2_ENST00000528391.2_Missense_Mutation_p.D141N|TIAM2_ENST00000456877.2_Missense_Mutation_p.D117N|TIAM2_ENST00000529824.2_Missense_Mutation_p.D805N|TIAM2_ENST00000360366.4_Missense_Mutation_p.D829N|TIAM2_ENST00000456144.1_Missense_Mutation_p.D805N			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	805					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGTTCCCCGAGACAATGCATG	0.403000													57	71					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19191795	19191795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:19191795C>T	ENST00000562034.1	+	2	3880	c.82C>T	c.(82-84)Ccg>Tcg	p.P28S	SYT17_ENST00000568115.1_Missense_Mutation_p.P28S|SYT17_ENST00000562711.2_Missense_Mutation_p.P85S|SYT17_ENST00000355377.2_Missense_Mutation_p.P89S			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	89	Cys-rich.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						GACCAATTCCCCGGATGGAAG	0.572000											OREG0023658	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	58					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50684558	50684558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50684558C>T	ENST00000446044.1	+	12	1516	c.920C>T	c.(919-921)tCg>tTg	p.S307L	MAPKAPK3_ENST00000357955.2_Missense_Mutation_p.S307L	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	307					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		TTCCAGCAATCGATGGTAGTG	0.602000													7	9					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7563999	7563999	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7563999G>A	ENST00000379802.3	+	6	1098	c.757G>A	c.(757-759)Gag>Aag	p.E253K	DSP_ENST00000418664.2_Missense_Mutation_p.E253K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	253	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCAGTTGGAGGAGGAGTATGA	0.398000													25	73					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497271	141497271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141497271C>T	ENST00000264952.2	+	1	282	c.145C>T	c.(145-147)Cgc>Tgc	p.R49C		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	49					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CGCGGAGCTCCGCCAGAAGCT	0.682000													5	33					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121447	50121447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50121447C>T	ENST00000374160.3	-	1	830	c.754G>A	c.(754-756)Gaa>Aaa	p.E252K	WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron|RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Missense_Mutation_p.E252K	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	252						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CTCCAGTCTTCCCAGGAGTCC	0.547000													72	145					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15637062	15637062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:15637062C>T	ENST00000281171.4	+	2	560	c.230C>T	c.(229-231)aCt>aTt	p.T77I	PTPRO_ENST00000348962.2_Missense_Mutation_p.T77I|PTPRO_ENST00000543886.1_Missense_Mutation_p.T77I	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	77	Fibronectin type-III 1.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TTCAACAGCACTTTGCCTCCT	0.393000													21	54					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196852768	196852768	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:196852768G>A	ENST00000312428.6	-	13	1639	c.1539C>T	c.(1537-1539)ctC>ctT	p.L513L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	513	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GATTTTCTGCGAGGAAGTTAT	0.348000													25	41					0	0	1	0	0
SMAD7	4092	broad.mit.edu	37	18	46447850	46447850	+	Silent	SNP	C	C	T	rs34151545	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:46447850C>T	ENST00000262158.2	-	4	1459	c.1173G>A	c.(1171-1173)acG>acA	p.T391T	SMAD7_ENST00000591805.1_Silent_p.T176T|SMAD7_ENST00000589634.1_Silent_p.T390T	NM_001190821.1|NM_005904.3	NP_001177750.1|NP_005895.1	O15105	SMAD7_HUMAN	SMAD family member 7	391	MH2.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	10	Colorectal(1;0.0518)					CGGTAAAGCCCGTCCACGGCT	0.577000													13	30					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52514365	52514365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52514365C>T	ENST00000488380.1	+	13	1607	c.1582C>T	c.(1582-1584)Ccc>Tcc	p.P528S	NISCH_ENST00000345716.4_Intron|NISCH_ENST00000420808.2_Intron|NISCH_ENST00000479054.1_Intron	NM_001276293.1	NP_001263222.1	Q9Y2I1	NISCH_HUMAN	nischarin	0	Interaction with PAK1 (By similarity).|Necessary for homooligomerization and targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TGCCTGGGCCCCCTGGCTGGG	0.647000													11	7					0	0	1	0	0
KANK3	256949	broad.mit.edu	37	19	8397899	8397899	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8397899C>T	ENST00000330915.3	-	7	2000	c.1936_splice	c.e7+1	p.T645_splice	KANK3_ENST00000593649.1_Splice_Site_p.T645_splice	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	645										breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GGCTCTGACCCGTATCCAGGA	0.632000													4	14					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35800925	35800925	+	Silent	SNP	C	C	T	rs148978165		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:35800925C>T	ENST00000361922.4	+	8	1530	c.1380C>T	c.(1378-1380)ttC>ttT	p.F460F	MAG_ENST00000593348.1_3'UTR|MAG_ENST00000392213.3_Silent_p.F460F|MAG_ENST00000537831.2_Silent_p.F435F	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	460	Ig-like C2-type 4.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			AGCGGGAGTTCGTGTACTCGG	0.682000													23	103					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974663	29974663	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29974663G>A	ENST00000376797.3	-	0	1346				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							CTACGTGGACGACACGCAGTT	0.667000													8	6					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134179608	134179608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:134179608G>A	ENST00000431683.2	+	11	1050	c.1050G>A	c.(1048-1050)atG>atA	p.M350I		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	350					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TTGGTTTCATGAACGGGGCCA	0.493000													4	20					0	0	1	0	0
FGFBP1	9982	broad.mit.edu	37	4	15938219	15938219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:15938219G>A	ENST00000382333.1	-	3	331	c.37C>T	c.(37-39)Cta>Tta	p.L13L	FGFBP1_ENST00000259988.2_Silent_p.L13L	NM_005130.4	NP_005121.1	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	13					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|prostate(2)|skin(1)	10						GCAGCCAGTAGGAGGAAGGAG	0.522000													16	90					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48346900	48346900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48346900G>A	ENST00000319856.4	+	1	429	c.408G>A	c.(406-408)gaG>gaA	p.E136E		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						GAGGTGTTGAGATCATTCTGC	0.483000													22	204					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79433634	79433634	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:79433634G>A	ENST00000554719.1	+	10	2233	c.1742G>A	c.(1741-1743)tGg>tAg	p.W581*	NRXN3_ENST00000335750.5_Nonsense_Mutation_p.W581*	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	173					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GACAACCAGTGGCACAATGTC	0.448000													7	88					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164272255	164272255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164272255G>A	ENST00000515560.1	+	4	2352	c.830G>A	c.(829-831)tGg>tAg	p.W277*	NPY5R_ENST00000506953.1_Nonsense_Mutation_p.W277*|NPY5R_ENST00000338566.3_Nonsense_Mutation_p.W277*			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	277					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				AGCCATAAATGGAGTTATTCA	0.398000													28	79					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26572089	26572089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:26572089G>A	ENST00000381340.3	-	50	7419	c.7003C>T	c.(7003-7005)Cgt>Tgt	p.R2335C	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2335					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					CGGTACCCACGGGTGAACGTG	0.433000													33	56					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96706525	96706525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:96706525C>T	ENST00000389672.5	+	3	840	c.802C>T	c.(802-804)Cgt>Tgt	p.R268C	EPHA6_ENST00000542517.1_Missense_Mutation_p.R174C|EPHA6_ENST00000470610.2_Missense_Mutation_p.R268C	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	173						integral to plasma membrane	ATP binding|ephrin receptor activity	p.R174C(3)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CACTGAAATTCGTGAGGTGGG	0.443000													89	238					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9998483	9998483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:9998483G>A	ENST00000506583.1	-	5	462	c.245C>T	c.(244-246)tCt>tTt	p.S82F	SLC2A9_ENST00000309065.3_Missense_Mutation_p.S82F|SLC2A9_ENST00000264784.3_Missense_Mutation_p.S111F			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	111					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						CACAGTCACAGACCAGAGCAA	0.453000													35	56					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51201152	51201152	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51201152G>A	ENST00000293441.1	-	12	1827	c.1809C>T	c.(1807-1809)ttC>ttT	p.F603F	SHANK1_ENST00000359082.3_Silent_p.F603F|SHANK1_ENST00000391814.1_Silent_p.F603F	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	603	SH3.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AGTCAGAGGGGAACCAGCCAA	0.552000													20	32					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15806999	15806999	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15806999G>A	ENST00000550308.1	+	11	1658	c.1278G>A	c.(1276-1278)ggG>ggA	p.G426G	CYP4F12_ENST00000324632.9_Silent_p.G426G	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ATATTATAGGGGTCCATCACA	0.552000													40	106					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104499567	104499567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104499567C>T	ENST00000361820.3	-	1	1295	c.695G>A	c.(694-696)aGt>aAt	p.S232N		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	232					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TCTCACCTGACTCTCCCGTGG	0.602000													13	34					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112021399	112021399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:112021399G>A	ENST00000354650.3	-	9	1376	c.770C>T	c.(769-771)tCt>tTt	p.S257F	FYN_ENST00000368682.3_Intron|FYN_ENST00000476769.2_5'UTR|FYN_ENST00000538466.1_Intron|FYN_ENST00000356013.2_Intron|FYN_ENST00000368678.4_Intron|FYN_ENST00000229470.5_Intron|FYN_ENST00000368667.2_Missense_Mutation_p.S257F|FYN_ENST00000229471.4_Intron	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	257					axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GGTTTTGACAGACAGATCGGT	0.537000													30	74					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377319	55377319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55377319C>T	ENST00000326321.3	+	7	1093	c.1060C>T	c.(1060-1062)Ctc>Ttc	p.L354F	KIR3DL2_ENST00000270442.5_Missense_Mutation_p.L337F|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.L354F	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	354					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		cctcttcatcctcctcctctt	0.493000													24	58					0	0	1	0	0
PDGFB	5155	broad.mit.edu	37	22	39629528	39629528	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:39629528C>T	ENST00000331163.6	-	3	949	c.160_splice	c.e3-1	p.E54_splice	PDGFB_ENST00000381551.4_Splice_Site_p.E39_splice	NM_002608.2	NP_002599.1	P01127	PDGFB_HUMAN	platelet-derived growth factor beta polypeptide	54					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(429)	central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Melanoma(58;0.04)				Becaplermin(DB00102)	CCCCATCTTCCTCTGCAGGAG	0.652000			T	COL1A1	DFSP								23	62					0	0	1	0	0
IGFBP4	3487	broad.mit.edu	37	17	38609376	38609376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38609376G>A	ENST00000269593.4	+	2	764	c.489G>A	c.(487-489)cgG>cgA	p.R163R	IGFBP4_ENST00000542955.1_Silent_p.R63R	NM_001552.2	NP_001543.2	P22692	IBP4_HUMAN	insulin-like growth factor binding protein 4	163					DNA metabolic process|signal transduction|skeletal system development					NS(1)|endometrium(1)|kidney(1)|large_intestine(2)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GGGCGCCCCGGGAGGATGCCC	0.617000													16	16					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66937441	66937441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:66937441C>T	ENST00000374690.3	+	5	2819	c.2295C>T	c.(2293-2295)ttC>ttT	p.F765F	AR_ENST00000396044.3_Intron|AR_ENST00000396043.2_Silent_p.F233F	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	764	Interaction with MYST2.|Ligand-binding.		A -> T (in AIS; loss of androgen binding).|A -> V (in AIS).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TGCTCTACTTCGCCCCTGATC	0.542000									Androgen Insensitivity Syndrome				24	19					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41729268	41729268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:41729268C>T	ENST00000242208.4	-	3	1507	c.1261G>A	c.(1261-1263)Gag>Aag	p.E421K	INHBA_ENST00000464515.1_5'UTR|INHBA_ENST00000442711.1_Missense_Mutation_p.E421K|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	421					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CCACACTCCTCCACGATCATG	0.463000										TSP Lung(11;0.080)			39	83					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22311705	22311705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:22311705G>A	ENST00000398793.2	-	18	2804	c.2370C>T	c.(2368-2370)ctC>ctT	p.L790L	TOP3B_ENST00000357179.5_Silent_p.L790L	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	790					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		CATCGCCCGGGAGTGGGGACT	0.642000													4	21					0	0	1	0	0
ALDOB	229	broad.mit.edu	37	9	104192174	104192174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:104192174G>A	ENST00000374855.4	-	3	311	c.187C>T	c.(187-189)Ctc>Ttc	p.L63F	ALDOB_ENST00000468981.2_Intron	NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	63					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				ACAGAGAAGAGGATTTCTCGG	0.552000													54	103					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38941514	38941514	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38941514G>A	ENST00000302328.3	-	13	2091	c.1893C>T	c.(1891-1893)ctC>ctT	p.L631L	SCN11A_ENST00000456224.3_Silent_p.L631L|SCN11A_ENST00000444237.2_Silent_p.L631L|SCN11A_ENST00000450244.1_Silent_p.L631L	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	631					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGTAGGGATCGAGCGCAATGA	0.413000													16	37					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142458111	142458111	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:142458111G>A	ENST00000430863.1	-	0	2795					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GGAGGGCCAGGAAGAGCTTGG	0.667000													7	8					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74640336	74640336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74640336G>A	ENST00000268053.6	-	2	484	c.330C>T	c.(328-330)ctC>ctT	p.L110L	CYP11A1_ENST00000358632.4_5'UTR|CYP11A1_ENST00000419019.2_Intron|CYP11A1_ENST00000541301.1_Silent_p.L110L	NM_000781.2	NP_000772.2	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	110					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CGGACTTAAAGAGAAGGGCCA	0.577000													14	66					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127776	152127776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152127776C>T	ENST00000316073.3	-	3	1863	c.1799G>A	c.(1798-1800)gGg>gAg	p.G600E		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	600	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TCCTTCAGTCCCTTGGAAGTA	0.453000													100	260					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3228099	3228099	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3228099C>T	ENST00000217939.6	-	7	8299	c.8145G>A	c.(8143-8145)acG>acA	p.T2715T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2715	Ig-like C2-type 11.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGCCGTACTCCGTCTCCATCC	0.617000													28	22					0	0	1	0	0
GNG4	2786	broad.mit.edu	37	1	235715446	235715446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:235715446G>A	ENST00000391854.2	-	4	644	c.191C>T	c.(190-192)cCc>cTc	p.P64L	GNG4_ENST00000366598.4_Missense_Mutation_p.P64L|GNG4_ENST00000484517.1_5'UTR|GNG4_ENST00000450593.1_Missense_Mutation_p.P64L|GNG4_ENST00000366597.1_Missense_Mutation_p.P64L	NM_001098722.1|NM_004485.3	NP_001092192.1|NP_004476.1	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein), gamma 4	64					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity			NS(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			CTCGCGAAAGGGGTTTTCTGA	0.522000													57	147					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61226934	61226934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:61226934G>A	ENST00000382768.1	+	3	427	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	SERPINB12_ENST00000269491.1_Missense_Mutation_p.E123K			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	123					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TGGAGAGCAGGAATTCCCAAT	0.463000													11	123					0	0	1	0	0
IPPK	64768	broad.mit.edu	37	9	95410411	95410411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:95410411G>A	ENST00000287996.3	-	6	710	c.434C>T	c.(433-435)cCt>cTt	p.P145L		NM_022755.5	NP_073592.1	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	145					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(2)|urinary_tract(1)	15						ACTCGAGAAAGGAATAAACCC	0.413000													4	31					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92251698	92251698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92251698G>A	ENST00000435962.2	-	11	1493	c.1170C>T	c.(1168-1170)ttC>ttT	p.F390F	TC2N_ENST00000340892.5_Silent_p.F390F|TC2N_ENST00000360594.5_Silent_p.F390F|TC2N_ENST00000556018.1_Silent_p.F326F	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	390	C2.					nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		CCACCTTCACGAAAAAACCTA	0.323000													82	215					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36227703	36227703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36227703C>T	ENST00000420124.1	+	31	7272	c.7272C>T	c.(7270-7272)ttC>ttT	p.F2424F	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Silent_p.F2424F																							AGGATGGGTTCAGCGTTGAGG	0.577000													27	67					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156378712	156378712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156378712G>A	ENST00000274532.2	-	3	546	c.490C>T	c.(490-492)Cca>Tca	p.P164S	TIMD4_ENST00000407087.3_Missense_Mutation_p.P164S	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	164	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTGCAGCTGGGGTTGTTGTC	0.532000													83	184					0	0	1	0	0
CABYR	26256	broad.mit.edu	37	18	21739520	21739520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21739520G>A	ENST00000399496.3	+	5	791	c.626G>A	c.(625-627)gGt>gAt	p.G209D	CABYR_ENST00000327201.6_Missense_Mutation_p.G111D|CABYR_ENST00000399481.2_3'UTR|CABYR_ENST00000581397.1_Missense_Mutation_p.G209D|RP11-799B12.4_ENST00000583267.1_lincRNA|CABYR_ENST00000399499.1_Missense_Mutation_p.G209D|CABYR_ENST00000415309.2_Intron	NM_012189.2|NM_153769.1	NP_036321.2|NP_722453.1	O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	394					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					AATCAACAAGGTCACCCATCA	0.443000													33	84					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60549102	60549102	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:60549102T>C	ENST00000373886.3	+	7	685	c.681T>C	c.(679-681)tcT>tcC	p.S227S		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	227					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						ATTCCCCCTCTATTCAGCATA	0.403000													44	98					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81212437	81212437	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81212437C>T	ENST00000394685.3	+	15	2219	c.1800C>T	c.(1798-1800)atC>atT	p.I600I	RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000356249.5_Silent_p.I600I|KIAA1199_ENST00000220244.3_Silent_p.I600I			Q8WUJ3	K1199_HUMAN	KIAA1199	600										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CCCTGCAGATCAAGGACGTTG	0.488000													63	64					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158323823	158323823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158323823G>A	ENST00000444681.2	+	1	338	c.45G>A	c.(43-45)ggG>ggA	p.G15G	CD1E_ENST00000368157.1_Silent_p.G15G|CD1E_ENST00000452291.2_Silent_p.G15G|CD1E_ENST00000368165.3_Silent_p.G15G|CD1E_ENST00000368163.3_Silent_p.G15G|CD1E_ENST00000368164.3_Silent_p.G15G|CD1E_ENST00000368155.3_Silent_p.G15G|CD1E_ENST00000368154.1_Silent_p.G15G|CD1E_ENST00000434258.1_Intron|CD1E_ENST00000368167.3_Silent_p.G15G|CD1E_ENST00000368156.1_Silent_p.G15G|CD1E_ENST00000368161.3_Silent_p.G15G|CD1E_ENST00000368160.3_Silent_p.G15G|CD1E_ENST00000368166.3_Silent_p.G15G	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	15			G -> E (in dbSNP:rs3180089).		antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GCTGTCCTGGGGAAAATACAG	0.542000													6	59					0	0	1	0	0
GPN3	51184	broad.mit.edu	37	12	110895368	110895368	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:110895368G>A	ENST00000543199.1	-	4	598	c.514C>T	c.(514-516)Cga>Tga	p.R172*	GPN3_ENST00000228827.3_Nonsense_Mutation_p.R133*|GPN3_ENST00000537466.2_Nonsense_Mutation_p.R143*	NM_001164372.1	NP_001157844.1	Q9UHW5	GPN3_HUMAN	GPN-loop GTPase 3	133						protein complex	GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|urinary_tract(1)	8						CCACAGACTCGGAACTCCCAC	0.393000													19	43					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96135801	96135801	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96135801C>T	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		ctcctgacctcgtgatccgcc	0.483000			T	TRA@	T-ALL								5	21					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176696688	176696688	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176696688C>T	ENST00000439151.2	+	16	5434	c.5389C>T	c.(5389-5391)Ctc>Ttc	p.L1797F	NSD1_ENST00000347982.4_Missense_Mutation_p.L1528F|NSD1_ENST00000361032.4_Missense_Mutation_p.L1694F|NSD1_ENST00000354179.4_Missense_Mutation_p.L1528F	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1797	PWWP 2.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GTTCCCAGTCCTCTTTTTTGG	0.498000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			28	78					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23379202	23379202	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23379202C>T	ENST00000343070.2	+	5	978	c.802C>T	c.(802-804)Cac>Tac	p.H268Y	SCNN1B_ENST00000307331.5_Missense_Mutation_p.H313Y|SCNN1B_ENST00000568085.1_Missense_Mutation_p.H268Y|SCNN1B_ENST00000568923.1_Missense_Mutation_p.H241Y	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	268					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CTTCTACCCTCACTATGGCAA	0.527000													35	132					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782829	54782829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54782829G>A	ENST00000391748.1	-	6	920	c.793C>T	c.(793-795)Cgc>Tgc	p.R265C	LILRB2_ENST00000391746.1_Missense_Mutation_p.R265C|LILRB2_ENST00000314446.5_Missense_Mutation_p.R265C|LILRB2_ENST00000434421.1_Missense_Mutation_p.R149C|LILRB2_ENST00000391749.4_Missense_Mutation_p.R265C	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	265	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGAGCTGGCGAAGGTCACGT	0.642000													16	85					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110489536	110489536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110489536C>T	ENST00000378402.5	+	53	9104	c.9000C>T	c.(8998-9000)ttC>ttT	p.F3000F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3000					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTATTAATTTCCAAGCTTACT	0.423000										HNSCC(38;0.096)			16	55					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113303820	113303820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113303820G>A	ENST00000297405.5	-	56	9137	c.8893C>T	c.(8893-8895)Cct>Tct	p.P2965S	CSMD3_ENST00000455883.2_Missense_Mutation_p.P2796S|CSMD3_ENST00000343508.3_Missense_Mutation_p.P2925S|CSMD3_ENST00000352409.3_Missense_Mutation_p.P2895S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2965	Sushi 20.					integral to membrane|plasma membrane		p.P2965S(1)|p.P2925S(1)|p.P2965T(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAATATCCAGGATTGCAGTCA	0.343000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	91					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38639232	38639232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38639232C>T	ENST00000413689.1	-	14	2443	c.2250G>A	c.(2248-2250)caG>caA	p.Q750Q	SCN5A_ENST00000423572.2_Silent_p.Q750Q|SCN5A_ENST00000425664.1_Silent_p.Q750Q|SCN5A_ENST00000333535.4_Silent_p.Q750Q|SCN5A_ENST00000451551.2_Silent_p.Q750Q|SCN5A_ENST00000455624.2_Silent_p.Q750Q|SCN5A_ENST00000449557.2_Silent_p.Q750Q|SCN5A_ENST00000450102.2_Silent_p.Q750Q|SCN5A_ENST00000443581.1_Silent_p.Q750Q|SCN5A_ENST00000414099.2_Silent_p.Q750Q	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	750					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGTTTCCGACCTGCAGCATCT	0.552000													13	46					0	0	1	0	0
CCDC134	79879	broad.mit.edu	37	22	42209433	42209433	+	Missense_Mutation	SNP	C	C	T	rs148694139		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:42209433C>T	ENST00000255784.5	+	5	580	c.476C>T	c.(475-477)tCg>tTg	p.S159L	CCDC134_ENST00000402061.3_Intron	NM_024821.2	NP_079097.1	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134	159						extracellular region				large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						GGGCCCCACTCGCCCATCCTC	0.587000													18	43					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3686422	3686422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:3686422C>T	ENST00000344754.4	-	3	674	c.675G>A	c.(673-675)agG>agA	p.R225R	SIGLEC1_ENST00000202578.4_Silent_p.R225R	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	225	Ig-like C2-type 1.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CGCTCTGAGCCCTGTGATTGG	0.627000													29	72					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56085986	56085986	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56085986C>T	ENST00000312711.1	+	1	204	c.204C>T	c.(202-204)ttC>ttT	p.F68F		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					ATCTGGCTTTCATGGATCTTG	0.383000													64	164					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144857686	144857686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:144857686G>A	ENST00000369359.4	-	42	6814	c.6776C>T	c.(6775-6777)tCc>tTc	p.S2259F	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S2123F|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S2017F|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S2208F|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S2123F|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2123					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAGAGCTGGGGAATTCATACC	0.522000			T	PDGFRB	MPD								46	199					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138293	126138293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:126138293G>A	ENST00000299308.3	+	9	2282	c.2274G>A	c.(2272-2274)ttG>ttA	p.L758L	TMEM132B_ENST00000535886.1_Silent_p.L270L	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	758						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAGGGCCTTTGATTAAGTTAG	0.438000													18	118					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125396438	125396438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:125396438G>A	ENST00000536769.1	-	1	3456	c.1880C>T	c.(1879-1881)cCc>cTc	p.P627L	UBC_ENST00000546120.1_Missense_Mutation_p.P551L|UBC_ENST00000538617.1_Missense_Mutation_p.P247L|UBC_ENST00000339647.5_Missense_Mutation_p.P627L			P0CG48	UBC_HUMAN	ubiquitin C	627	Ubiquitin-like 9.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGTGTCACTGGGCTCCACCTC	0.527000													63	167					0	0	1	0	0
CHST10	9486	broad.mit.edu	37	2	101012051	101012051	+	Silent	SNP	G	G	A	rs138672369		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:101012051G>A	ENST00000264249.3	-	6	838	c.453C>T	c.(451-453)atC>atT	p.I151I	CHST10_ENST00000409701.1_Silent_p.I151I|CHST10_ENST00000542617.1_Silent_p.I199I	NM_004854.4	NP_004845.1	O43529	CHSTA_HUMAN	carbohydrate sulfotransferase 10	151					carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)	16						CGTTTTCGGGGATCTCCTCAA	0.522000													28	77					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25243010	25243010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:25243010C>T	ENST00000354454.3	+	13	1314	c.485C>T	c.(484-486)tCt>tTt	p.S162F	LRMP_ENST00000548766.1_Missense_Mutation_p.S162F|LRMP_ENST00000547044.1_Missense_Mutation_p.S162F	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	218					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					CTCAGATTATCTTTGGGATTT	0.393000													47	114					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32868615	32868615	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32868615C>T	ENST00000380250.3	+	60	9187	c.8691C>T	c.(8689-8691)acC>acT	p.T2897T	FRY_ENST00000380217.1_Silent_p.T79T|FRY_ENST00000542859.1_Silent_p.T267T	NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2897					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCGAGCCCACCTTCACGTCCA	0.557000													24	74					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109683539	109683539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109683539C>T	ENST00000338432.7	+	38	5406	c.5287C>T	c.(5287-5289)Cct>Tct	p.P1763S	ACACB_ENST00000377848.3_Missense_Mutation_p.P1763S|ACACB_ENST00000377854.5_Missense_Mutation_p.P1693S|ACACB_ENST00000543201.1_Missense_Mutation_p.P429S			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1763					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GAACCGACTTCCTGGTGGAAA	0.507000													24	67					0	0	1	0	0
TNFSF8	944	broad.mit.edu	37	9	117666496	117666496	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117666496G>A	ENST00000223795.2	-	4	533	c.420C>T	c.(418-420)ttC>ttT	p.F140F	TNFSF8_ENST00000474301.1_Intron	NM_001244.3	NP_001235.1	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily, member 8	140					cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(3)|urinary_tract(1)	12						GGCAAATGATGAAGTACAAAC	0.413000													66	101					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94899510	94899510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:94899510G>A	ENST00000357742.4	+	8	1150	c.1150G>A	c.(1150-1152)Gat>Aat	p.D384N	MCTP2_ENST00000543482.1_Missense_Mutation_p.D384N|MCTP2_ENST00000557742.1_5'UTR|MCTP2_ENST00000451018.3_Missense_Mutation_p.D384N|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	384	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAAACTGGGAGATCAGAGGTA	0.333000													57	66					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114296106	114296106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114296106G>A	ENST00000309235.5	+	4	747	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	ZNF483_ENST00000355824.3_Missense_Mutation_p.E197K|ZNF483_ENST00000358151.4_Missense_Mutation_p.E197K	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	197	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GCTATATAAGGAAGTGCTACT	0.398000													55	77					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10031943	10031943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10031943C>T	ENST00000396573.2	-	4	1189	c.880G>A	c.(880-882)Gac>Aac	p.D294N	GRIN2A_ENST00000535259.1_Missense_Mutation_p.D137N|GRIN2A_ENST00000404927.2_Missense_Mutation_p.D294N|GRIN2A_ENST00000562109.1_Missense_Mutation_p.D294N|GRIN2A_ENST00000330684.3_Missense_Mutation_p.D294N|GRIN2A_ENST00000396575.2_Missense_Mutation_p.D294N	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	294					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCAATGCCGTCCCTCACTCTC	0.572000													16	38					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41400142	41400142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:41400142C>T	ENST00000373198.3	-	5	852	c.617G>A	c.(616-618)gGg>gAg	p.G206E	PTPRT_ENST00000373187.1_Missense_Mutation_p.G206E|PTPRT_ENST00000373193.3_Missense_Mutation_p.G206E|PTPRT_ENST00000373201.1_Missense_Mutation_p.G206E|PTPRT_ENST00000373184.1_Missense_Mutation_p.G206E|PTPRT_ENST00000356100.2_Missense_Mutation_p.G206E|PTPRT_ENST00000373190.1_Missense_Mutation_p.G206E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	206	Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCATTCTGCCCCACATTCAC	0.493000													56	164					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100010	110100010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110100010C>T	ENST00000518632.1	+	2	620	c.269C>T	c.(268-270)tCc>tTc	p.S90F	TRHR_ENST00000311762.2_Missense_Mutation_p.S90F			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	90						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			ATCTACGGTTCCTGGGTCTAT	0.498000													20	101					0	0	1	0	0
REN	5972	broad.mit.edu	37	1	204129793	204129793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204129793G>A	ENST00000367195.2	-	4	430	c.387C>T	c.(385-387)ctC>ctT	p.L129L	REN_ENST00000272190.8_Silent_p.L129L			P00797	RENI_HUMAN	renin	129					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AAGCATCGAAGAGCTTGTGAT	0.552000													31	93					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47514289	47514289	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47514289G>A	ENST00000371901.3	+	10	1510	c.1260G>A	c.(1258-1260)tgG>tgA	p.W420*	CYP4X1_ENST00000538609.1_Nonsense_Mutation_p.W419*	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	420						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						CTGCTGTCTGGAAAAACCCAA	0.418000													63	171					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6184597	6184597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6184597C>T	ENST00000261405.5	-	7	1032	c.778G>A	c.(778-780)Ggg>Agg	p.G260R		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	260					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CACTCCAGCCCCCCAGCACAC	0.642000													8	52					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74673193	74673193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:74673193C>T	ENST00000334011.5	+	6	1136	c.918C>T	c.(916-918)ctC>ctT	p.L306L		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	306	ZP.					nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					TCAACATCCTCTTCTCTCTCA	0.552000													35	71					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105415701	105415701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105415701C>T	ENST00000333244.5	-	7	6206	c.6087G>A	c.(6085-6087)ggG>ggA	p.G2029G	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2029						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTTCAGGTCCCCCTGCATGG	0.662000													86	88					0	0	1	0	0
NDUFB4	4710	broad.mit.edu	37	3	120319969	120319969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:120319969C>T	ENST00000485064.1	+	2	224	c.192C>T	c.(190-192)gcC>gcT	p.A64A	NDUFB4_ENST00000184266.2_Silent_p.A64A|NDUFB4_ENST00000492739.1_Intron	NM_001168331.1	NP_001161803.1	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa	64					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|large_intestine(1)|lung(3)	5				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	AAAATCCTGCCTTGCTTCGTT	0.393000													44	141					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22059407	22059407	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22059407C>T	ENST00000306385.5	+	16	2869	c.2199C>T	c.(2197-2199)ttC>ttT	p.F733F	BMP1_ENST00000354870.5_3'UTR	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	733	EGF-like 2; calcium-binding (Potential).				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GCAGTGGCTTCGTCCTCCATG	0.602000													4	23					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540532	94540532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94540532C>T	ENST00000289495.5	+	1	1323	c.1107C>T	c.(1105-1107)ttC>ttT	p.F369F	PPP1R9A_ENST00000424654.1_Silent_p.F369F|PPP1R9A_ENST00000433360.1_Silent_p.F369F|PPP1R9A_ENST00000340694.4_Silent_p.F369F|PPP1R9A_ENST00000456331.2_Silent_p.F369F|PPP1R9A_ENST00000433881.1_Silent_p.F369F	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	369						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GTGGTGATTTCACCTCTCCTG	0.433000										HNSCC(28;0.073)			32	56					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43411770	43411770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43411770G>A	ENST00000310826.5	-	3	2618	c.2435C>T	c.(2434-2436)cCc>cTc	p.P812L	ZBTB21_ENST00000465968.1_5'UTR|ZBTB21_ENST00000398511.3_Missense_Mutation_p.P812L|ZBTB21_ENST00000398499.1_Missense_Mutation_p.P812L|ZBTB21_ENST00000398505.3_Missense_Mutation_p.P611L	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		GTCCAAAACGGGCAAAGAAAA	0.502000													42	93					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169433294	169433294	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169433294C>T	ENST00000261509.6	+	2	850	c.639C>T	c.(637-639)gcC>gcT	p.A213A	PALLD_ENST00000333488.4_Silent_p.A90A|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Silent_p.A213A	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	213					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		AGCCGTCAGCCCTGCTGAGTG	0.552000									Pancreatic Cancer, Familial Clustering of				16	107					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107732807	107732807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107732807C>T	ENST00000388781.3	-	13	1608	c.1525G>A	c.(1525-1527)Gat>Aat	p.D509N	LAMB4_ENST00000205386.4_Missense_Mutation_p.D509N|LAMB4_ENST00000414450.2_Missense_Mutation_p.D509N|LAMB4_ENST00000388780.3_Missense_Mutation_p.D509N	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	509	Laminin EGF-like 5; truncated.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CCTCCAATATCACAGTCACAG	0.383000													24	58					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18753417	18753417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18753417G>A	ENST00000380548.4	+	16	2467	c.2128G>A	c.(2128-2130)Gag>Aag	p.E710K		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	710	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCTGGCTGATGAGCTGTGTCG	0.567000													8	13					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72538330	72538330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:72538330C>T	ENST00000299290.1	-	6	879	c.490G>A	c.(490-492)Gaa>Aaa	p.E164K	TBATA_ENST00000456372.2_Missense_Mutation_p.E164K|TBATA_ENST00000545575.1_Missense_Mutation_p.E153K	NM_152710.2	NP_689923.2			thymus, brain and testes associated																		TTCTTCAGTTCATCCTCCTTG	0.557000													71	160					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219883777	219883777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:219883777C>T	ENST00000341552.5	-	21	3681	c.3598G>A	c.(3598-3600)Gac>Aac	p.D1200N	CCDC108_ENST00000453220.1_Missense_Mutation_p.D1200N|CCDC108_ENST00000441968.1_Missense_Mutation_p.D1200N	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1200						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCATACCAGTCCAGGGACACC	0.602000													15	188					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158283902	158283902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:158283902C>T	ENST00000264192.3	-	6	628	c.507G>A	c.(505-507)ctG>ctA	p.L169L	CYTIP_ENST00000540637.1_Silent_p.L63L	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	169	Interaction with CYTH1.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						CCGTTCTTTTCAGAATCATTG	0.348000													11	25					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16528293	16528293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:16528293G>A	ENST00000270747.3	-	14	2266	c.2130C>T	c.(2128-2130)gtC>gtT	p.V710V	ARHGEF19_ENST00000421561.1_Intron|ARHGEF19_ENST00000478117.1_5'UTR	NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	710					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCACTGATGACCTCCTTGT	0.592000													7	29					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47538583	47538583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:47538583G>A	ENST00000300527.4	+	13	1276	c.1172G>A	c.(1171-1173)gGa>gAa	p.G391E	COL6A2_ENST00000310645.5_Missense_Mutation_p.G391E|COL6A2_ENST00000357838.4_Missense_Mutation_p.G391E|COL6A2_ENST00000409416.1_Missense_Mutation_p.G391E|COL6A2_ENST00000397763.1_Missense_Mutation_p.G391E	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	391	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GGGGCCAAGGGAAGCAAGGTG	0.642000													6	14					0	0	1	0	0
FGF18	8817	broad.mit.edu	37	5	170883572	170883572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:170883572C>T	ENST00000274625.5	+	5	931	c.387C>T	c.(385-387)ttC>ttT	p.F129F		NM_003862.2	NP_003853.1	O76093	FGF18_HUMAN	fibroblast growth factor 18	129					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	9	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGTGTGTGTTCATCGAGAAGG	0.567000													32	81					0	0	1	0	0
SLC9A8	23315	broad.mit.edu	37	20	48472032	48472032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:48472032C>T	ENST00000417961.1	+	8	885	c.675C>T	c.(673-675)ttC>ttT	p.F225F	SLC9A8_ENST00000539601.1_5'UTR|SLC9A8_ENST00000361573.2_Silent_p.F209F|SLC9A8_ENST00000541138.1_5'UTR	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	209						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TTGCCATTTTCAATGCACTTC	0.478000													42	101					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36271691	36271691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36271691C>T	ENST00000007510.4	+	10	946	c.802C>T	c.(802-804)Ccc>Tcc	p.P268S	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.P132S|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.P268S			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	268					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CATCCCGGCTCCCCAGGGTAT	0.622000													31	95					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132161206	132161206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:132161206G>A	ENST00000378679.3	-	4	1431	c.627C>T	c.(625-627)gcC>gcT	p.A209A	SHROOM1_ENST00000319854.3_Silent_p.A209A|SHROOM1_ENST00000378676.1_Silent_p.A209A	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	209	ASD1.				actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACCCCGGCCGGCAGTTCCTG	0.771000													6	5					0	0	1	0	0
ALDOA	226	broad.mit.edu	37	16	30081507	30081507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30081507C>T	ENST00000566897.1	+	12	2221	c.1069C>T	c.(1069-1071)Ctc>Ttc	p.L357F	ALDOA_ENST00000564595.2_Missense_Mutation_p.L411F|ALDOA_ENST00000569798.1_3'UTR|ALDOA_ENST00000569545.1_Missense_Mutation_p.L357F|ALDOA_ENST00000412304.2_Missense_Mutation_p.L357F|ALDOA_ENST00000395248.1_Missense_Mutation_p.L411F|ALDOA_ENST00000338110.5_Missense_Mutation_p.L357F|ALDOA_ENST00000395240.3_Missense_Mutation_p.L361F|ALDOA_ENST00000564546.1_Missense_Mutation_p.L357F|ALDOA_ENST00000563060.2_Missense_Mutation_p.L357F			P04075	ALDOA_HUMAN	aldolase A, fructose-bisphosphate	357					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	17						CAGCGAGTCCCTCTTCGTCTC	0.632000													23	88					0	0	1	0	0
NT5E	4907	broad.mit.edu	37	6	86181095	86181095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:86181095G>A	ENST00000257770.3	+	3	752	c.703G>A	c.(703-705)Ggt>Agt	p.G235S	NT5E_ENST00000369651.3_Missense_Mutation_p.G235S|NT5E_ENST00000369646.3_Missense_Mutation_p.G235S	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	235					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	GAAAGTGAGGGGTGTGGACGT	0.423000													26	48					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50684298	50684298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50684298G>A	ENST00000355832.5	-	12	2423	c.2345C>T	c.(2344-2346)tCc>tTc	p.S782F	ERCC6_ENST00000542458.1_Missense_Mutation_p.S152F	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	782					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AACTTCTTTGGAATCAACGAA	0.378000								Direct reversal of damage;Nucleotide excision repair (NER)					21	76					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247737544	247737544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247737544G>A	ENST00000366491.2	+	7	705	c.208G>A	c.(208-210)Gag>Aag	p.E70K	RP11-978I15.10_ENST00000446347.1_RNA|GCSAML_ENST00000527084.1_Missense_Mutation_p.E58K|GCSAML_ENST00000463359.1_Missense_Mutation_p.E58K|GCSAML_ENST00000366488.4_Missense_Mutation_p.E90K|RP11-978I15.10_ENST00000435333.1_RNA|GCSAML_ENST00000366489.1_Missense_Mutation_p.E70K|GCSAML_ENST00000527541.1_Missense_Mutation_p.E58K|GCSAML_ENST00000536561.1_Missense_Mutation_p.E70K					germinal center-associated, signaling and motility-like																		TGATGGCTATGAGAACATTGA	0.458000													25	70					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648064	112648064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:112648064G>A	ENST00000471858.1	-	3	656	c.424C>T	c.(424-426)Cat>Tat	p.H142Y	CD200R1_ENST00000308611.3_Missense_Mutation_p.H165Y|CD200R1_ENST00000440122.2_Missense_Mutation_p.H165Y|CD200R1_ENST00000295863.4_Missense_Mutation_p.H120Y|CD200R1_ENST00000490004.1_Missense_Mutation_p.H142Y	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	142	Ig-like C2-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TATCCACGATGGAAATTCCCA	0.438000													31	98					0	0	1	0	0
TP53TG3D	729264	broad.mit.edu	37	16	32264999	32264999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:32264999C>T	ENST00000398664.3	+	1	960	c.325C>T	c.(325-327)Cgg>Tgg	p.R109W	RP11-56L13.7_ENST00000562604.1_RNA|TP53TG3D_ENST00000569631.1_Intron|TP53TG3D_ENST00000354614.3_Missense_Mutation_p.R109W	NM_001243722.1	NP_001230651.1			TP53 target 3D																		AACAAAGGGTCGGTGGCCTCT	0.572000													20	100					0	0	1	0	0
ARIH2	10425	broad.mit.edu	37	3	49006032	49006032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49006032C>T	ENST00000356401.4	+	7	943	c.604C>T	c.(604-606)Ccc>Tcc	p.P202S	ARIH2_ENST00000449376.1_Missense_Mutation_p.P202S|ARIH2_ENST00000490095.1_3'UTR	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	202					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		TCCATTGCTTCCCAATGAAGA	0.522000													60	152					0	0	1	0	0
RNASE7	84659	broad.mit.edu	37	14	21511371	21511371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21511371G>A	ENST00000298690.4	+	2	477	c.220G>A	c.(220-222)Gag>Aag	p.E74K	NDRG2_ENST00000403829.3_Intron	NM_032572.3	NP_115961.2	Q9H1E1	RNAS7_HUMAN	ribonuclease, RNase A family, 7	74					defense response to bacterium|innate immune response	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	6	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;3.42e-11)|Epithelial(56;5.57e-09)|all cancers(55;2.36e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CTTCCTGCACGAGCCTTTCTC	0.542000													26	92					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8420714	8420714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8420714G>A	ENST00000337907.3	-	19	3487	c.2853C>T	c.(2851-2853)ctC>ctT	p.L951L	RERE_ENST00000476556.1_Silent_p.L397L|RERE_ENST00000377464.1_Silent_p.L683L|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Silent_p.L951L	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	951	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGGGCCCCGAGAGGTGGGGAG	0.692000													18	51					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10942968	10942968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10942968G>A	ENST00000298232.7	-	11	932	c.565C>T	c.(565-567)Cat>Tat	p.H189Y	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.H169Y|TPTE_ENST00000361285.4_Missense_Mutation_p.H207Y	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	207					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAAACAGATGAAAAATTCTT	0.308000													7	74					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13922350	13922350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:13922350G>A	ENST00000265104.4	-	5	630	c.526C>T	c.(526-528)Ctc>Ttc	p.L176F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	176	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTGGCTCTGAGAGCAGGAATG	0.552000									Kartagener syndrome				19	47					0	0	1	0	0
E2F8	79733	broad.mit.edu	37	11	19253875	19253875	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:19253875G>A	ENST00000527884.1	-	7	1204	c.972C>T	c.(970-972)agC>agT	p.S324S	E2F8_ENST00000250024.4_Silent_p.S324S|RP11-428C19.4_ENST00000527978.1_RNA	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	324					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TAAGATCCAGGCTACTCAGAA	0.363000													56	131					0	0	1	0	0
RPL13A	23521	broad.mit.edu	37	19	49993505	49993505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49993505C>T	ENST00000391857.4	+	3	181	c.105C>T	c.(103-105)gtC>gtT	p.V35V	RPL13A_ENST00000477613.2_3'UTR	NM_001270491.1|NM_012423.3	NP_001257420.1|NP_036555.1	P40429	RL13A_HUMAN	ribosomal protein L13a	35					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome			cervix(1)|endometrium(1)	2		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		AGGTGGTGGTCGTACGCTGTG	0.577000													18	39					0	0	1	0	0
FAM133A	286499	broad.mit.edu	37	X	92964424	92964424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:92964424G>A	ENST00000538690.1	+	5	567	c.6G>A	c.(4-6)ggG>ggA	p.G2G	FAM133A_ENST00000332647.4_Silent_p.G2G|FAM133A_ENST00000322139.4_Silent_p.G2G|FAM133A_ENST00000355813.5_Silent_p.G2G	NM_001171110.1	NP_001164581.1	Q8N9E0	F133A_HUMAN	family with sequence similarity 133, member A	2										breast(2)|endometrium(2)|large_intestine(8)|lung(7)|upper_aerodigestive_tract(1)	20						GCACCATGGGGAAGCGGGATA	0.443000													11	14					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19745391	19745391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19745391G>A	ENST00000203556.4	-	18	2146	c.2009C>T	c.(2008-2010)tCg>tTg	p.S670L	GMIP_ENST00000587238.1_Missense_Mutation_p.S644L|GMIP_ENST00000445806.2_Missense_Mutation_p.S641L|GMIP_ENST00000586269.1_Intron	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	670	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GGTCTTCAGCGAGCGGATAAC	0.602000													78	138					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53854576	53854576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53854576G>A	ENST00000315251.5	-	6	1482	c.1045C>T	c.(1045-1047)Cct>Tct	p.P349S		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase	349					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	AGGGTGATAGGGCGGGTGCAT	0.552000													41	90					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176031	57176031	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:57176031G>A	ENST00000537055.2	-	2	767	c.536C>T	c.(535-537)tCg>tTg	p.S179L		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						CGCCAGGTACGAGCCCTGGCT	0.706000													9	20					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78647157	78647157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:78647157G>A	ENST00000286627.5	-	27	4356	c.3404C>T	c.(3403-3405)tCc>tTc	p.S1135F	KCNMA1_ENST00000372440.1_Missense_Mutation_p.S1135F|KCNMA1_ENST00000354353.5_Missense_Mutation_p.S1196F|KCNMA1_ENST00000404857.1_Missense_Mutation_p.S1176F|KCNMA1_ENST00000406533.3_Missense_Mutation_p.S1197F|KCNMA1_ENST00000286628.8_Missense_Mutation_p.S1193F|KCNMA1_ENST00000404771.3_Missense_Mutation_p.S1193F|KCNMA1_ENST00000372443.1_Missense_Mutation_p.S1162F	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	1193					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CGACGAGTGGGAGGAATGGGA	0.602000													23	64					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661269	77661269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77661269G>A	ENST00000296043.6	+	5	2896	c.1943G>A	c.(1942-1944)gGc>gAc	p.G648D		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	648					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GAAGGCCTAGGCCAGAGCCTG	0.557000													48	108					0	0	1	0	0
PMP2	5375	broad.mit.edu	37	8	82357106	82357106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:82357106G>A	ENST00000256103.2	-	2	328	c.192C>T	c.(190-192)tcC>tcT	p.S64S	PMP2_ENST00000519260.1_Intron|RP11-157I4.4_ENST00000524085.2_RNA	NM_002677.3	NP_002668.1	P02689	MYP2_HUMAN	peripheral myelin protein 2	64						cytoplasm	cholesterol binding|fatty acid binding|transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			Epithelial(68;0.186)			CTAGCTTGAAGGAGATTTCTG	0.393000													9	78					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225639752	225639752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:225639752G>A	ENST00000409592.3	-	52	5978	c.5865C>T	c.(5863-5865)atC>atT	p.I1955I	DOCK10_ENST00000258390.7_Silent_p.I1961I			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1961	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TCCGGTCTTCGATTTCCTTTT	0.507000													16	44					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52323898	52323898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:52323898C>T	ENST00000356297.4	-	16	2074	c.1974G>A	c.(1972-1974)atG>atA	p.M658I	PXDNL_ENST00000543296.1_Missense_Mutation_p.M658I	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	658					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGCTCTTGCCATTTCCACAA	0.498000													10	14					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651391	1651391	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1651391G>A	ENST00000399676.2	+	1	359	c.321G>A	c.(319-321)ggG>ggA	p.G107G		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	107	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGTCCAAGGGGGCCTGTGGCT	0.687000													53	111					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756928	248756928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248756928G>A	ENST00000330500.2	-	1	172	c.142C>T	c.(142-144)Ctg>Ttg	p.L48L		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGTGGATCAGAAGTATCAAT	0.418000													29	80					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51173332	51173332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:51173332C>T	ENST00000440970.1	-	2	2941	c.2510G>A	c.(2509-2511)aGc>aAc	p.S837N	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.S934N	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	934					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTCCTGCGTGCTGTTGGACGG	0.557000													9	65					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127561577	127561577	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:127561577A>G	ENST00000373580.3	+	4	476	c.476A>G	c.(475-477)aAc>aGc	p.N159S		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	159										endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						ATCAAGGCCAACCTGAGCCGG	0.582000													15	56					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993086	28993086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28993086C>T	ENST00000359747.4	+	15	2737	c.2708C>T	c.(2707-2709)aCt>aTt	p.T903I	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.T884I|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	884					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TCAGGATTGACTCCCTCAGAA	0.428000													53	119					0	0	1	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65715015	65715015	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65715015G>A	ENST00000532620.1	+	0	950							Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein											endometrium(2)|kidney(3)|lung(9)	14						CGCCCCAGGAGGGGGTCGATC	0.632000													16	43					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38574572	38574572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38574572C>T	ENST00000356264.2	-	2	324	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	AMPH_ENST00000428293.2_Missense_Mutation_p.E37K|AMPH_ENST00000325590.5_Missense_Mutation_p.E37K	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	37	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						TCGAACTGTTCGTCTTTTGTC	0.348000													8	95					0	0	1	0	0
CDK20	23552	broad.mit.edu	37	9	90584785	90584785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90584785G>A	ENST00000375883.3	-	5	856	c.550C>T	c.(550-552)Ccg>Tcg	p.P184S	CDK20_ENST00000375871.4_Intron|CDK20_ENST00000325303.8_Missense_Mutation_p.P205S|CDK20_ENST00000336654.5_Missense_Mutation_p.P197S|CDK20_ENST00000605159.1_Missense_Mutation_p.P184S	NM_001170639.1|NM_012119.4|NM_178432.3	NP_001164110.1|NP_036251.2|NP_848519.1	Q8IZL9	CDK20_HUMAN	cyclin-dependent kinase 20	205	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						TTCTTGCCCGGGAAAAGGGGG	0.577000													7	73					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35988894	35988894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:35988894C>T	ENST00000297866.5	+	11	1890	c.1824C>T	c.(1822-1824)ttC>ttT	p.F608F		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	608										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GGCCAATTTTCACAAAAGTTC	0.289000													7	5					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184299059	184299059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184299059G>A	ENST00000330394.2	+	15	3203	c.2751G>A	c.(2749-2751)ctG>ctA	p.L917L	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	917						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGCCCCTCCTGGACCGCACGG	0.577000													45	110					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349971	100349971	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100349971C>T	ENST00000542585.1	+	0	2391				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCACCATCCCCACAGAAAAA	0.522000													28	61					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588480	20588480	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20588480G>A	ENST00000428453.1	-	0	4270																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GTGTCCCCAGGACACCATCAA	0.488000													7	23					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192700901	192700901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:192700901G>A	ENST00000304141.4	-	2	1355	c.1026C>T	c.(1024-1026)ctC>ctT	p.L342L		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	342						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GAGCGCTGGCGAGGGACGCTT	0.557000													42	121					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54856572	54856572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:54856572C>T	ENST00000333896.5	+	13	2647	c.2262C>T	c.(2260-2262)gtC>gtT	p.V754V	SPTBN1_ENST00000356805.4_Silent_p.V767V	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	767					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			TCAAGATTGTCTCCAGCAGCG	0.562000													22	67					0	0	1	0	0
VMO1	284013	broad.mit.edu	37	17	4688690	4688690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4688690C>T	ENST00000328739.5	-	3	655	c.576G>A	c.(574-576)ctG>ctA	p.L192L	VMO1_ENST00000416307.2_3'UTR|VMO1_ENST00000441199.2_3'UTR|VMO1_ENST00000354194.4_3'UTR	NM_182566.2	NP_872372.1	Q7Z5L0	VMO1_HUMAN	vitelline membrane outer layer 1 homolog (chicken)	192					vitelline membrane formation	extracellular region				kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|pancreas(1)	11						GCGCGTCGTTCAGCGCAGTGT	0.642000													19	21					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102470966	102470966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:102470966C>T	ENST00000360184.4	+	24	5159	c.4995C>T	c.(4993-4995)atC>atT	p.I1665I		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	1665	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CGAGCATCATCCTGAACGAGG	0.378000													25	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067484	9067484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9067484G>A	ENST00000397910.4	-	3	20165	c.19962C>T	c.(19960-19962)tcC>tcT	p.S6654S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6656	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATGAGCCAGGGAGAATGTTG	0.502000													33	71					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94878997	94878997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:94878997G>A	ENST00000358746.2	-	5	423	c.125C>T	c.(124-126)gCc>gTc	p.A42V		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	42							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						AAAAACCCAGGCATTATAGTT	0.353000													16	127					0	0	1	0	0
SHC4	399694	broad.mit.edu	37	15	49160046	49160046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:49160046G>A	ENST00000332408.4	-	6	1343	c.915C>T	c.(913-915)gcC>gcT	p.A305A	SHC4_ENST00000537958.1_Silent_p.A19A|SHC4_ENST00000396535.3_Silent_p.A62A	NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	305	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TAGCTACGTAGGCAACATAGT	0.323000													15	89					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26462936	26462936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26462936G>A	ENST00000265944.5	+	30	3909	c.3743G>A	c.(3742-3744)aGg>aAg	p.R1248K	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1248					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						ACAGAGGAGAGGAATTGTGAA	0.438000													17	70					0	0	1	0	0
MSS51	118490	broad.mit.edu	37	10	75184446	75184446	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75184446G>A	ENST00000299432.2	-	7	1313	c.1248C>T	c.(1246-1248)tcC>tcT	p.S416S	MSS51_ENST00000372912.1_Silent_p.S416S	NM_001024593.1	NP_001019764.1	Q4VC12	ZMY17_HUMAN	MSS51 mitochondrial translational activator	416							zinc ion binding										CAGGTTTGAGGGACATGAAAG	0.453000													12	115					0	0	1	0	0
SSX3	10214	broad.mit.edu	37	X	48213490	48213490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:48213490C>T	ENST00000298396.2	-	4	276	c.224G>A	c.(223-225)cGg>cAg	p.R75Q	SSX3_ENST00000376893.3_Missense_Mutation_p.R75Q	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	75	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						GTCTGTGACCCGTTTATTACG	0.483000													16	100					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119750854	119750854	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:119750854G>A	ENST00000541757.1	+	17	1553	c.1173G>A	c.(1171-1173)agG>agA	p.R391R	MARCO_ENST00000327097.4_Silent_p.R469R			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	469	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						CCAAAGGAAGGGCCCTGTACA	0.542000													27	97					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140277573	140277573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140277573G>A	ENST00000458420.3	+	12	2105	c.1915G>A	c.(1915-1917)Ggc>Agc	p.G639S		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	639					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CACCCTCCGGGGCACAGACCA	0.557000										HNSCC(16;0.037)			26	70					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39672164	39672164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:39672164C>T	ENST00000398930.1	+	4	1335	c.981C>T	c.(979-981)ttC>ttT	p.F327F	KCNJ15_ENST00000398938.2_Silent_p.F327F|KCNJ15_ENST00000398932.1_Silent_p.F327F|KCNJ15_ENST00000398934.1_Silent_p.F327F|KCNJ15_ENST00000328656.3_Silent_p.F327F			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	327					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						TGGCTGATTTCAGTCAGTTTG	0.443000													25	69					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10356180	10356180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10356180C>T	ENST00000255381.2	-	25	3291	c.3181G>A	c.(3181-3183)Ggt>Agt	p.G1061S	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1061					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTTAGGTCACCCTCCAGTTTT	0.343000													69	96					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106797653	106797653	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:106797653C>T	ENST00000276185.4	+	9	780	c.780C>T	c.(778-780)ctC>ctT	p.L260L	FRMPD3_ENST00000477796.1_3'UTR			Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	260	FERM.					cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						TGAAATGCCTCTTCCGAATAA	0.502000													5	14					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20666274	20666274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20666274G>A	ENST00000357366.3	+	1	780	c.780G>A	c.(778-780)gtG>gtA	p.V260V		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTCTGGTCGTGAGAGCTGTGT	0.507000													51	251					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22155483	22155483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22155483C>T	ENST00000397126.4	-	4	2501	c.2353G>A	c.(2353-2355)Gct>Act	p.A785T	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CGGTTAAAAGCTTTGCCACAT	0.363000													22	57					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218940025	218940025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:218940025G>A	ENST00000374155.3	+	8	1280	c.870G>A	c.(868-870)ggG>ggA	p.G290G	RUFY4_ENST00000344321.7_Silent_p.G270G|RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000463872.1_3'UTR			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	270							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGCCAGAAGGGAAGGAGCTTC	0.547000													4	12					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99060038	99060038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:99060038C>T	ENST00000357310.1	+	9	1842	c.1265C>T	c.(1264-1266)tCt>tTt	p.S422F	APAF1_ENST00000547045.1_Missense_Mutation_p.S422F|APAF1_ENST00000359972.2_Missense_Mutation_p.S411F|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000339433.3_Missense_Mutation_p.S422F|APAF1_ENST00000549007.1_Missense_Mutation_p.S422F|APAF1_ENST00000550527.1_Missense_Mutation_p.S411F|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000551964.1_Missense_Mutation_p.S422F	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	422					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	GTAAATAAGTCTCTTTTATTC	0.353000													40	96					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82807962	82807962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82807962C>T	ENST00000265077.3	+	6	1354	c.789C>T	c.(787-789)ttC>ttT	p.F263F	VCAN_ENST00000512590.2_Silent_p.F215F|VCAN_ENST00000513984.1_Silent_p.F263F|VCAN_ENST00000502527.2_Silent_p.F263F|VCAN_ENST00000343200.5_Silent_p.F263F|VCAN_ENST00000342785.4_Silent_p.F263F	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	263	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AATTCACCTTCGAGGAGGCTG	0.488000													19	54					0	0	1	0	0
TRGV3	6976	broad.mit.edu	37	7	38398395	38398395	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38398395C>T	ENST00000390346.2	-	0	254																											ACTTCGTTCTCCCTTCCAAGT	0.438000													19	105					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240016749	240016749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:240016749G>A	ENST00000345617.3	-	17	3013	c.2222C>T	c.(2221-2223)tCg>tTg	p.S741L	HDAC4_ENST00000541256.1_Missense_Mutation_p.S715L|HDAC4_ENST00000543185.1_Missense_Mutation_p.S325L	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	741	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GGAGGCGAGCGAGCCTGTGGG	0.617000													42	111					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178410187	178410187	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178410187G>A	ENST00000231188.5	-	9	2338	c.2160C>T	c.(2158-2160)ccC>ccT	p.P720P	GRM6_ENST00000517717.1_Silent_p.P720P|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	720					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CGCTGTGTGGGGGCCGGGCCC	0.602000													18	41					0	0	1	0	0
OR4S1	256148	broad.mit.edu	37	11	48328312	48328312	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48328312C>T	ENST00000319988.1	+	1	538	c.538C>T	c.(538-540)Cat>Tat	p.H180Y		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						CTGTGATGTTCATCCCCTGCT	0.493000													32	28					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	95001578	95001578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:95001578C>T	ENST00000265627.5	-	4	284	c.274G>A	c.(274-276)Gaa>Aaa	p.E92K	PON1_ENST00000542556.1_Intron|PON3_ENST00000427422.1_Missense_Mutation_p.E92K	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			GGGTTTTGTTCATTCAGATCC	0.378000													24	83					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86392931	86392931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:86392931G>A	ENST00000285379.5	+	7	926	c.696G>A	c.(694-696)ggG>ggA	p.G232G		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	232					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	ACTTCAATGGGGAGGGTGAAC	0.393000													23	45					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371608	240371608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240371608C>T	ENST00000319653.9	+	5	3726	c.3496C>T	c.(3496-3498)Ccc>Tcc	p.P1166S		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1166	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ACCCCCACCTCCCCCTCTACC	0.692000													16	22					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165867	172165867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:172165867C>T	ENST00000241256.2	-	1	379	c.337G>A	c.(337-339)Gac>Aac	p.D113N	GHSR_ENST00000427970.1_Missense_Mutation_p.D113N	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	113					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CAGAGGAGGTCGCCGAAGTTC	0.602000													13	33					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52942175	52942175	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52942175C>T	ENST00000332323.6	+	4	1562	c.1501C>T	c.(1501-1503)Cat>Tat	p.H501Y	ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Missense_Mutation_p.H488Y|ZNF534_ENST00000301085.4_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						TAGGAAAATTCATACTGGAGA	0.403000													3	18					0	0	1	0	0
MOGAT2	80168	broad.mit.edu	37	11	75439890	75439890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:75439890C>T	ENST00000526712.1	+	4	1233	c.460C>T	c.(460-462)Ccc>Tcc	p.P154S	MOGAT2_ENST00000198801.5_Missense_Mutation_p.P236S			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	236					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					TGACCAGATTCCCAACTCTTC	0.532000													46	93					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83549998	83549998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:83549998C>T	ENST00000296591.5	-	2	518	c.100G>A	c.(100-102)Gga>Aga	p.G34R	EDIL3_ENST00000380138.3_Missense_Mutation_p.G34R	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	34	EGF-like 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		CAGATACCTCCATTTTCACAT	0.393000													25	46					0	0	1	0	0
OR1D5	8386	broad.mit.edu	37	17	2966524	2966524	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:2966524G>A	ENST00000575751.1	-	1	377	c.378C>T	c.(376-378)acC>acT	p.T126T		NM_014566.1	NP_055381.1	P58170	OR1D5_HUMAN	olfactory receptor, family 1, subfamily D, member 5	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|lung(10)	11						GGGGGCAGCAGGTGGCCACAT	0.582000													22	37					0	0	1	0	0
TNFRSF1B	7133	broad.mit.edu	37	1	12253142	12253142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12253142C>T	ENST00000376259.3	+	6	863	c.774C>T	c.(772-774)ttC>ttT	p.F258F	TNFRSF1B_ENST00000492361.1_3'UTR	NM_001066.2	NP_001057.1	P20333	TNR1B_HUMAN	tumor necrosis factor receptor superfamily, member 1B	258					apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(1)|liver(1)|lung(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	CTGGCGACTTCGCTCTTCCAG	0.547000													4	30					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961963	34961963	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34961963C>T	ENST00000329357.5	+	1	1051	c.1015C>T	c.(1015-1017)Cat>Tat	p.H339Y		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	339										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCCCAACACTCATCGGGTGTC	0.587000													35	16					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96904252	96904252	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96904252G>A	ENST00000267584.4	+	6	734	c.690_splice	c.e6+1	p.K230_splice		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	230					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CATTTTTTAAGGTATGGCTTT	0.398000													6	64					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149428833	149428833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:149428833C>T	ENST00000255992.10	+	17	2614	c.2215C>T	c.(2215-2217)Ctg>Ttg	p.L739L	KRBA1_ENST00000319551.8_Silent_p.L679L|KRBA1_ENST00000485033.2_Silent_p.L679L|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	740	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATCCAGAGGCCTGGAGCTTGG	0.587000													4	13					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183521816	183521816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:183521816C>T	ENST00000305135.5	+	27	3819	c.3624C>T	c.(3622-3624)atC>atT	p.I1208I		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1208					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TACAAGAAATCCTGGAGAAGA	0.443000													56	92					0	0	1	0	0
FAM83A	84985	broad.mit.edu	37	8	124195392	124195392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124195392C>T	ENST00000518448.1	+	2	2310	c.296C>T	c.(295-297)tCc>tTc	p.S99F	FAM83A_ENST00000318462.6_Missense_Mutation_p.S99F|FAM83A_ENST00000276699.6_Missense_Mutation_p.S99F|FAM83A_ENST00000546351.1_Missense_Mutation_p.S99F|FAM83A_ENST00000536633.1_Missense_Mutation_p.S99F|FAM83A_ENST00000522648.1_Missense_Mutation_p.S99F			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	99										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GACTCCAGCTCCCTACAGTCC	0.662000													11	103					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65909275	65909275	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:65909275C>T	ENST00000321892.4	+	13	5714	c.5653C>T	c.(5653-5655)Cct>Tct	p.P1885S	BPTF_ENST00000306378.6_Missense_Mutation_p.P1759S|BPTF_ENST00000424123.3_Missense_Mutation_p.P1746S|BPTF_ENST00000335221.5_Missense_Mutation_p.P1885S			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1885					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATATCCTTCTCCTAGACCGAC	0.373000													54	170					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74901259	74901259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74901259C>T	ENST00000569840.2	+	7	1273	c.699C>T	c.(697-699)ttC>ttT	p.F233F	MGAT5B_ENST00000374998.3_3'UTR|MGAT5B_ENST00000301618.4_Silent_p.F233F|MGAT5B_ENST00000428789.2_Silent_p.F244F	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	233						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGGCAGTTTTCCGAAGCAACC	0.637000													9	19					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67058534	67058534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:67058534C>T	ENST00000295568.4	+	4	1584	c.1453C>T	c.(1453-1455)Cgt>Tgt	p.R485C	KBTBD8_ENST00000417314.2_Missense_Mutation_p.R511C|KBTBD8_ENST00000460576.1_Missense_Mutation_p.R69C	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	511										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		TAAATGGACTCGTAAGAAAGA	0.368000													34	99					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47432804	47432804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47432804C>T	ENST00000285039.7	-	19	2698	c.2399G>A	c.(2398-2400)gGa>gAa	p.G800E		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	800	IQ 2.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GGCCAGGTGTCCCCGGCAGTA	0.582000													8	48					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839271	100839271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100839271C>T	ENST00000223114.4	-	7	1148	c.982G>A	c.(982-984)Gaa>Aaa	p.E328K	MOGAT3_ENST00000440203.2_3'UTR|MOGAT3_ENST00000379423.3_Missense_Mutation_p.G260E	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	328					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					CCACAGCTTTCCTTGTGCTCC	0.647000													32	59					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42490132	42490132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42490132C>T	ENST00000545399.1	-	6	682	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K	ATP1A3_ENST00000302102.5_Missense_Mutation_p.E164K|ATP1A3_ENST00000602133.1_Missense_Mutation_p.E134K|ATP1A3_ENST00000543770.1_Missense_Mutation_p.E175K	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	164					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						TTCTCACCTTCCCGGATCACC	0.622000													31	119					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31318223	31318223	+	Missense_Mutation	SNP	G	G	A	rs146973182		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:31318223G>A	ENST00000380490.3	+	2	195	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	ALOX5AP_ENST00000479597.1_3'UTR	NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	33					cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		AGTGGAGCACGAAAGCAGGAC	0.498000													7	56					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236653459	236653459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:236653459C>T	ENST00000409538.1	+	5	1805	c.1309C>T	c.(1309-1311)Cct>Tct	p.P437S	AGAP1_ENST00000304032.7_Missense_Mutation_p.P172S|AGAP1_ENST00000409457.1_Missense_Mutation_p.P172S|AGAP1_ENST00000336665.5_Missense_Mutation_p.P172S|AGAP1_ENST00000428334.2_Missense_Mutation_p.P11S			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	172	PH.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GAGCGAGATTCCTCTGGTTCT	0.433000													19	52					0	0	1	0	0
HOXC4	3221	broad.mit.edu	37	12	54448806	54448806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54448806C>T	ENST00000430889.2	+	2	658	c.612C>T	c.(610-612)ttC>ttT	p.F204F	HOXC4_ENST00000303406.4_Silent_p.F204F	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	204						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						AAATCTGGTTCCAAAACCGTC	0.567000													15	25					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52587970	52587970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:52587970C>T	ENST00000395489.2	-	9	1065	c.669G>A	c.(667-669)gtG>gtA	p.V223V	A1CF_ENST00000395495.1_Intron|A1CF_ENST00000373993.1_Silent_p.V230V|A1CF_ENST00000374001.1_Silent_p.V230V|A1CF_ENST00000373995.3_Silent_p.V238V|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000373997.3_Silent_p.V230V|A1CF_ENST00000282641.2_Silent_p.V230V	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	230					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ATAGGATTTTCACTGAAGACA	0.363000													26	79					0	0	1	0	0
NELFB	25920	broad.mit.edu	37	9	140151279	140151279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140151279C>T	ENST00000343053.4	+	4	707	c.370C>T	c.(370-372)Ccg>Tcg	p.P124S		NM_015456.3	NP_056271.2			negative elongation factor complex member B																		CATGTAGGTTCCGGAGAAAAA	0.582000													18	19					0	0	1	0	0
EFCAB5	374786	broad.mit.edu	37	17	28414151	28414151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:28414151C>T	ENST00000394835.3	+	19	3842	c.3650C>T	c.(3649-3651)cCt>cTt	p.P1217L	EFCAB5_ENST00000320856.5_Missense_Mutation_p.P1093L|EFCAB5_ENST00000394832.2_Intron	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	1217							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CACAAAAATCCTCCTACCATC	0.418000													28	32					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62372641	62372641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62372641G>A	ENST00000394773.2	-	16	2233	c.1926C>T	c.(1924-1926)ctC>ctT	p.L642L	EML3_ENST00000529309.1_Silent_p.L642L|EML3_ENST00000278845.4_Silent_p.L643L|EML3_ENST00000494176.2_Silent_p.L614L|EML3_ENST00000531557.1_Silent_p.L425L	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	642						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						AGTCAGCACAGAGACCAGTCT	0.562000													33	61					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14751223	14751223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14751223C>T	ENST00000284268.6	-	5	972	c.642G>A	c.(640-642)aaG>aaA	p.K214K	ANKH_ENST00000535119.1_Silent_p.K16K|ANKH_ENST00000503939.1_5'UTR	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	214					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CGTGAATGTTCTTGTAGTAGC	0.562000													23	66					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317513	30317513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:30317513C>T	ENST00000375377.1	-	3	1665	c.1564G>A	c.(1564-1566)Gca>Aca	p.A522T		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	522										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TGTCCCCTTGCCACACAGCGG	0.642000													44	130					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77639588	77639588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:77639588G>A	ENST00000534064.1	-	11	1205	c.1171C>T	c.(1171-1173)Cgt>Tgt	p.R391C	INTS4_ENST00000529807.1_Missense_Mutation_p.R391C|INTS4_ENST00000525931.1_5'UTR	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	391					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			GCAGCAATACGAACCTCTAGA	0.493000													3	15					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49663097	49663097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49663097C>T	ENST00000249601.4	-	6	1036	c.740G>A	c.(739-741)aGg>aAg	p.R247K	ARHGAP22_ENST00000417912.2_Missense_Mutation_p.R263K|ARHGAP22_ENST00000374170.1_Intron|ARHGAP22_ENST00000417247.2_Missense_Mutation_p.R157K|ARHGAP22_ENST00000374172.1_Missense_Mutation_p.R138K|ARHGAP22_ENST00000435790.2_Missense_Mutation_p.R253K	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	247	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GTCCTCGTACCTGGCGAAGGG	0.667000													6	22					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129279547	129279547	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:129279547C>T	ENST00000393239.1	-	30	5191	c.5013G>A	c.(5011-5013)gaG>gaA	p.E1671E	PLXND1_ENST00000324093.4_Silent_p.E1671E			Q9Y4D7	PLXD1_HUMAN	plexin D1	1671					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GGAAATACTTCTCTGTGTCCA	0.512000													26	65					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876418	35876418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35876418C>T	ENST00000303115.3	+	8	1339	c.1210C>T	c.(1210-1212)Ctc>Ttc	p.L404F	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	404					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GTACCAGGACCTCCTGCTTAG	0.552000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						15	43					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38692558	38692558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:38692558C>T	ENST00000222345.6	+	20	5550	c.5041C>T	c.(5041-5043)Ccg>Tcg	p.P1681S		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1681					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCCGGACATCCCGCCTGCACA	0.657000													16	46					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36322207	36322207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36322207C>T	ENST00000378910.5	-	26	3377	c.3378G>A	c.(3376-3378)caG>caA	p.Q1126Q	NPHS1_ENST00000353632.6_Silent_p.Q1086Q	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	1126					cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCGTGGAGCTCTGAGTGTCCC	0.597000													29	73					0	0	1	0	0
OGFOD3	79701	broad.mit.edu	37	17	80361910	80361910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:80361910G>A	ENST00000313056.5	-	7	753	c.602C>T	c.(601-603)tCc>tTc	p.S201F	OGFOD3_ENST00000329197.5_Missense_Mutation_p.S201F	NM_024648.2|NM_175902.4	NP_078924.1|NP_787098.3			2-oxoglutarate and iron-dependent oxygenase domain containing 3																		ATGCAGCGAGGATGCGCTGAT	0.627000													4	8					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16875962	16875962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16875962C>T	ENST00000524140.2	+	10	2787	c.2369C>T	c.(2368-2370)gCc>gTc	p.A790V	NWD1_ENST00000523826.1_Missense_Mutation_p.A584V|NWD1_ENST00000379808.3_Missense_Mutation_p.A790V|NWD1_ENST00000552788.1_Missense_Mutation_p.A790V|NWD1_ENST00000339803.6_Missense_Mutation_p.A655V|NWD1_ENST00000549814.1_Missense_Mutation_p.A790V	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	790							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GTCCGTGAAGCCCTCCAGCTC	0.617000													16	30					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130284070	130284070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130284070C>T	ENST00000358511.6	+	3	925	c.894C>T	c.(892-894)aaC>aaT	p.N298N	COL6A6_ENST00000453409.2_Silent_p.N298N	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	298	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ATATACAGAACCTTTCTCCCC	0.478000													19	84					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156816422	156816422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156816422G>A	ENST00000347377.6	+	29	3864	c.3433G>A	c.(3433-3435)Gag>Aag	p.E1145K	CYFIP2_ENST00000541131.1_Missense_Mutation_p.E1070K|CYFIP2_ENST00000318218.6_Missense_Mutation_p.E1170K|CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000522463.1_Missense_Mutation_p.E949K|CYFIP2_ENST00000521420.1_Missense_Mutation_p.E1119K|CYFIP2_ENST00000377576.3_Missense_Mutation_p.E1145K|CYFIP2_ENST00000435847.2_Missense_Mutation_p.E844K	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1170					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGAACCAACGAGTTCACAGC	0.597000													5	16					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902127	51902127	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:51902127G>A	ENST00000268919.4	+	1	1889	c.1733G>A	c.(1732-1734)aGg>aAg	p.R578K		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	578					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TCCCTTCAGAGGGATGAATTT	0.418000													32	63					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151304045	151304045	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151304045A>G	ENST00000370323.4	-	4	364	c.48T>C	c.(46-48)ctT>ctC	p.L16L	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Silent_p.L16L	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	16										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGGGATTGAAGATCTTCTT	0.572000													29	29					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77691837	77691837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77691837G>A	ENST00000296043.6	+	10	6361	c.5408G>A	c.(5407-5409)aGc>aAc	p.S1803N	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1803	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GCGAAGGGGAGCCTGCTCACG	0.547000													26	88					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70840074	70840074	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:70840074G>A	ENST00000322773.4	+	18	1444	c.1341_splice	c.e18-1	p.G448_splice	COL19A1_ENST00000393344.1_Splice_Site_p.G70_splice	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	448	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TCACCCCTAGGGAAATGATGA	0.368000													13	28					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94519722	94519722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:94519722C>T	ENST00000375708.3	-	3	493	c.295G>A	c.(295-297)Gat>Aat	p.D99N	ROR2_ENST00000375715.1_5'UTR|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	99	Ig-like C2-type.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						ACCGGGGCATCATTCTTTAGC	0.562000													35	105					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103032171	103032171	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103032171G>A	ENST00000306312.3	-	11	1392	c.1131C>T	c.(1129-1131)gcC>gcT	p.A377A	SLC26A5_ENST00000393730.1_Silent_p.A377A|SLC26A5_ENST00000432958.2_Silent_p.A377A|SLC26A5_ENST00000393729.1_Silent_p.A340A|SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000339444.6_Silent_p.A377A|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000393727.1_Silent_p.A377A|SLC26A5_ENST00000393735.2_Silent_p.A377A|SLC26A5_ENST00000393723.1_Silent_p.A377A	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	377					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						ACAGTCCCAGGGCAATGAGCT	0.438000													6	26					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325800	31325800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:31325800G>A	ENST00000269197.5	+	12	5988	c.5988G>A	c.(5986-5988)atG>atA	p.M1996I		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1996					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding	p.K1997fs*4(1)		breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ATATGCCCATGAAAGAAGGTG	0.547000													10	128					0	0	1	0	0
WIPF3	644150	broad.mit.edu	37	7	29924037	29924037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:29924037C>T	ENST00000409290.1	+	4	927	c.927C>T	c.(925-927)ccC>ccT	p.P309P	WIPF3_ENST00000409123.1_Silent_p.P309P|WIPF3_ENST00000242140.5_Silent_p.P309P	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	309										breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						CTTCTTTGCCCGCGCCCCCTT	0.687000													5	7					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735501	140735501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140735501C>T	ENST00000571252.1	+	1	734	c.734C>T	c.(733-735)cCc>cTc	p.P245L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCACTCAGCCCGAGTACCAC	0.537000													15	26					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36116684	36116684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36116684G>A	ENST00000296603.4	-	11	1776	c.1314C>T	c.(1312-1314)ttC>ttT	p.F438F		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	438						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGATGGAAAGGAAGCAGGCAA	0.338000													10	70					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52472087	52472087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52472087G>A	ENST00000231721.2	-	14	1637	c.1638C>T	c.(1636-1638)tcC>tcT	p.S546S		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	546					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		AGTGGGTACAGGAGGCACCAT	0.677000													10	29					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25322252	25322252	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25322252G>A	ENST00000549804.2	+	0	1243				SNORD116-12_ENST00000384468.1_RNA																							TAAAATGAATGAAAACTCTAT	0.428000													26	104					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44553214	44553214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:44553214C>T	ENST00000289547.4	-	20	3967	c.3912G>A	c.(3910-3912)caG>caA	p.Q1304Q	NPC1L1_ENST00000381160.3_Silent_p.Q1277Q|NPC1L1_ENST00000546276.1_Silent_p.Q1231Q	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1304					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	CAGCCCGCTTCTGCTCCAGTG	0.597000													29	54					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130877827	130877827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:130877827C>T	ENST00000357462.5	-	1	355	c.262G>A	c.(262-264)Gac>Aac	p.D88N	POTEF_ENST00000360967.5_Missense_Mutation_p.D88N|POTEF_ENST00000409914.2_Missense_Mutation_p.D88N|POTEF_ENST00000361163.4_Missense_Mutation_p.D88N			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	88						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						ATAGCAGAGTCGTCGTGGTCT	0.617000													21	371					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56639294	56639294	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56639294G>A	ENST00000267116.7	-	21	2392	c.2271C>T	c.(2269-2271)ccC>ccT	p.P757P		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	757							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						CCAGGTGAATGGGCGTGCGGC	0.622000													22	43					0	0	1	0	0
GABRG2	2566	broad.mit.edu	37	5	161524820	161524820	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:161524820G>A	ENST00000356592.3	+	4	964	c.504G>A	c.(502-504)agG>agA	p.R168R	GABRG2_ENST00000393933.4_Silent_p.R73R|GABRG2_ENST00000414552.2_Silent_p.R168R|GABRG2_ENST00000361925.4_Silent_p.R168R	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	168					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CCCCCAACAGGATGCTGAGAA	0.418000													34	85					0	0	1	0	0
ZBTB11	27107	broad.mit.edu	37	3	101390172	101390172	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:101390172G>A	ENST00000312938.4	-	3	1160	c.580C>T	c.(580-582)Cca>Tca	p.P194S	ZBTB11_ENST00000461821.1_3'UTR	NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						CAATGTTTTGGAGAAGAACGT	0.368000													50	151					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48318309	48318309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48318309G>A	ENST00000435803.1	+	18	7542	c.7518G>A	c.(7516-7518)ttG>ttA	p.L2506L		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2506					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCATGCTGTTGAATGACAGTG	0.428000													27	243					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32264687	32264687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32264687C>T	ENST00000343380.5	-	7	1304	c.1165G>A	c.(1165-1167)Gag>Aag	p.E389K		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	389	Transactivation.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						GAGAAGTCCTCCCGCACATGC	0.687000													3	6					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98289598	98289598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:98289598C>T	ENST00000322128.3	-	1	578	c.475G>A	c.(475-477)Ggg>Agg	p.G159R		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	159					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					ACCTGAGGCCCCCTCCCCGCG	0.642000													48	112					0	0	1	0	0
MARCH8	220972	broad.mit.edu	37	10	45953750	45953750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:45953750G>A	ENST00000453424.2	-	8	1920	c.1659C>T	c.(1657-1659)tcC>tcT	p.S553S	MARCH8_ENST00000395771.3_Silent_p.S271S|MARCH8_ENST00000319836.3_Silent_p.S271S|MARCH8_ENST00000395769.2_Silent_p.S271S|MARCH8_ENST00000476962.1_5'UTR			Q5T0T0	MARH8_HUMAN	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	271						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	12						AGTTTGTGTCGGAATGACAGA	0.393000													10	98					0	0	1	0	0
FUBP3	8939	broad.mit.edu	37	9	133488412	133488412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:133488412C>T	ENST00000319725.9	+	5	419	c.344C>T	c.(343-345)tCa>tTa	p.S115L		NM_003934.1	NP_003925.1	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	115	KH 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		CAGATTGCTTCAGGTAAGGGC	0.373000													24	42					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32445998	32445998	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:32445998G>A	ENST00000266088.4	+	2	454	c.204G>A	c.(202-204)tgG>tgA	p.W68*		NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	68					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						TGGTGTGGTGGCCGGTAAGTT	0.453000													106	165					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75403345	75403345	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:75403345C>T	ENST00000297784.5	+	14	1515	c.975C>T	c.(973-975)atC>atT	p.I325I	TMC1_ENST00000340019.3_Silent_p.I325I|TMC1_ENST00000396237.3_Silent_p.I325I	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	325					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						ACTACCTGATCGGCAATCCTG	0.398000													21	55					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413859	48413859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48413859C>T	ENST00000249598.1	-	2	1168	c.1009G>A	c.(1009-1011)Gag>Aag	p.E337K		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	337					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CCGATGTCCTCGAAGTTTACC	0.612000													28	80					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183675643	183675643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183675643C>T	ENST00000511685.1	+	22	4246	c.4123C>T	c.(4123-4125)Cgc>Tgc	p.R1375C	TENM3_ENST00000406950.2_Missense_Mutation_p.R1375C|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3									p.R1375C(1)									TCGTCAAGTTCGCATTGCTGC	0.493000													6	22					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58078924	58078924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:58078924C>T	ENST00000219271.3	+	10	2369	c.1584C>T	c.(1582-1584)ttC>ttT	p.F528F		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	528	Hemopexin-like 4.				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						ACACCTACTTCTACAAGGGCA	0.587000													13	34					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1415401	1415401	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:1415401C>T	ENST00000446702.2	+	15	2527	c.1900C>T	c.(1900-1902)Cag>Tag	p.Q634*	CNTN6_ENST00000539053.1_Nonsense_Mutation_p.Q562*|CNTN6_ENST00000350110.2_Nonsense_Mutation_p.Q634*			Q9UQ52	CNTN6_HUMAN	contactin 6	634	Fibronectin type-III 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATTTACTATTCAGACTCGGAC	0.398000													39	86					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1734132	1734132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:1734132G>A	ENST00000381241.3	+	1	239	c.40G>A	c.(40-42)Gac>Aac	p.D14N	ASMT_ENST00000381233.3_Missense_Mutation_p.D14N|ASMT_ENST00000381229.4_Missense_Mutation_p.D14N	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	14					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTCCTTAATGACTACGCCAA	0.552000													4	3					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45284584	45284584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45284584C>T	ENST00000270279.3	+	3	684	c.621C>T	c.(619-621)tcC>tcT	p.S207S	CBLC_ENST00000341505.4_Silent_p.S207S	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	207	Cbl-PTB.|EF-hand-like.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				GGCACGTGTCCATCTTCGAGT	0.607000			M		AML								30	77					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101488063	101488063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101488063G>A	ENST00000392979.3	+	17	1987	c.1626G>A	c.(1624-1626)acG>acA	p.T542T	ANO4_ENST00000392977.3_Silent_p.T577T|ANO4_ENST00000550015.1_Silent_p.T97T|ANO4_ENST00000299222.9_Silent_p.T97T	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	577						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TGCTTCTGACGAATTTAGGTG	0.328000										HNSCC(74;0.22)			26	56					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96937849	96937849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96937849G>A	ENST00000267584.4	+	13	1436	c.1392G>A	c.(1390-1392)atG>atA	p.M464I		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	464	Adenylate kinase.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TTAGATTTATGAAAGAAAAGC	0.289000													22	52					0	0	1	0	0
CEACAM1	634	broad.mit.edu	37	19	43026203	43026203	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:43026203C>T	ENST00000161559.6	-	3	710	c.576G>A	c.(574-576)caG>caA	p.Q192Q	CEACAM1_ENST00000358394.3_Silent_p.Q192Q|CEACAM1_ENST00000352591.5_Silent_p.Q192Q|LIPE-AS1_ENST00000594688.1_RNA|CEACAM1_ENST00000351134.3_Intron|CEACAM1_ENST00000599389.1_Silent_p.Q192Q|CEACAM1_ENST00000403461.1_Silent_p.Q192Q|LIPE-AS1_ENST00000457234.2_RNA|CEACAM1_ENST00000403444.3_Silent_p.Q192Q|CEACAM1_ENST00000308072.4_Silent_p.Q152Q|LIPE-AS1_ENST00000594624.2_RNA	NM_001712.4	NP_001703.2	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	192	Ig-like C2-type 1.				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	17		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	CATTGGACAGCTGCAGCCTGG	0.532000													60	264					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55814181	55814181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55814181C>T	ENST00000309383.1	+	10	1251	c.974C>T	c.(973-975)tCa>tTa	p.S325L	BRSK1_ENST00000326848.7_Missense_Mutation_p.S20L|BRSK1_ENST00000585418.1_Missense_Mutation_p.S325L|BRSK1_ENST00000590333.1_Missense_Mutation_p.S341L	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	325	UBA.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		AGCATGGCATCACTGGGCTGC	0.682000													24	60					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108723676	108723676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108723676C>T	ENST00000232603.5	-	20	2155	c.2073G>A	c.(2071-2073)ctG>ctA	p.L691L	MORC1_ENST00000483760.1_Silent_p.L670L	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	691					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						GGGCATTCTTCAGGCACCCTT	0.338000													106	311					0	0	1	0	0
LCN12	286256	broad.mit.edu	37	9	139847361	139847361	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139847361C>T	ENST00000371633.3	+	2	132	c.132C>T	c.(130-132)ttC>ttT	p.F44F		NM_178536.3	NP_848631.2	Q6JVE5	LCN12_HUMAN	lipocalin 12	44					lipid metabolic process	extracellular region	binding|transporter activity			endometrium(1)|kidney(1)|lung(1)|prostate(2)	5	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		GGGAATGGTTCGTCCTGGGCC	0.672000													61	130					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3139548	3139548	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3139548C>T	ENST00000252463.2	-	5	1809	c.1722G>A	c.(1720-1722)acG>acA	p.T574T	ZSCAN10_ENST00000575108.1_Silent_p.T235T|ZSCAN10_ENST00000538082.2_Silent_p.T492T	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	574					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						GCTTCTCGCCCGTGTGGCTGC	0.711000													3	10					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647777	51647777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51647777C>T	ENST00000317643.6	+	2	617	c.548C>T	c.(547-549)tCc>tTc	p.S183F	SIGLEC7_ENST00000600577.1_Intron|SIGLEC7_ENST00000305628.7_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	183	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding	p.S183C(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CCTATGATCTCCTGGATGGGG	0.652000													58	150					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583815	82583815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82583815C>T	ENST00000423517.2	-	5	6791	c.6454G>A	c.(6454-6456)Gaa>Aaa	p.E2152K	PCLO_ENST00000333891.8_Missense_Mutation_p.E2152K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2083					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTTGAATTTCTCTTGTATAA	0.413000													33	63					0	0	1	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134497252	134497252	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:134497252G>A	ENST00000372195.1	-	11	2079	c.1836C>T	c.(1834-1836)tcC>tcT	p.S612S	RAPGEF1_ENST00000372189.3_Silent_p.S595S|RAPGEF1_ENST00000372190.3_Silent_p.S613S			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	595					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CCCCACTGAAGGAGTCGCTGA	0.612000													6	15					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39934344	39934344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:39934344C>T	ENST00000564288.1	+	96	22606	c.21829C>T	c.(21829-21831)Cgc>Tgc	p.R7277C	MACF1_ENST00000289893.4_Missense_Mutation_p.R5720C|MACF1_ENST00000545844.1_Missense_Mutation_p.R5212C|MACF1_ENST00000539005.1_Missense_Mutation_p.R5082C|MACF1_ENST00000372915.3_Missense_Mutation_p.R7170C|MACF1_ENST00000361689.2_Missense_Mutation_p.R5212C|MACF1_ENST00000317713.7_Missense_Mutation_p.R5212C|MACF1_ENST00000567887.1_Missense_Mutation_p.R7314C			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	7170	C-terminal tail (By similarity).|Ser-rich.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CGTGATGGTTCGCGTTGGTGG	0.433000													28	58					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182563248	182563248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:182563248C>T	ENST00000323116.5	+	9	967	c.707C>T	c.(706-708)cCt>cTt	p.P236L	ATP11B_ENST00000482794.1_3'UTR	NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	236					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TTTCCTAGACCTCTGGGGCCG	0.333000													9	44					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148975505	148975505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:148975505C>T	ENST00000434415.1	+	5	852	c.689C>T	c.(688-690)cCa>cTa	p.P230L	ZNF783_ENST00000489518.1_3'UTR	NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	230					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			CCTCCGTATCCAGAGCACCTC	0.607000													12	27					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600728	29600728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:29600728C>T	ENST00000431530.3	+	1	1981	c.1923C>T	c.(1921-1923)ccC>ccT	p.P641P		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	631	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AAACTAAGCCCATCATTATGC	0.542000													4	37					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79748963	79748963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79748963C>T	ENST00000305428.3	+	2	549	c.474C>T	c.(472-474)tgC>tgT	p.C158C		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	158						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CGTCCAAGTGCCGGAAGATGG	0.567000													21	71					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075049	106075049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106075049C>T	ENST00000278071.2	-	3	1213	c.761G>A	c.(760-762)aGc>aAc	p.S254N	ITPRIP_ENST00000358187.2_Missense_Mutation_p.S254N|ITPRIP_ENST00000337478.1_Missense_Mutation_p.S254N	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	254						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						GCAGATGCAGCTCAATGTGTC	0.652000													17	41					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64967823	64967823	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:64967823C>G	ENST00000326648.3	+	4	2898	c.2770C>G	c.(2770-2772)Ctg>Gtg	p.L924V		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	924						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAGCCAGGCCCTGAAGACAAA	0.507000													16	193					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768863	57768863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57768863C>T	ENST00000371030.2	+	1	2789	c.2789C>T	c.(2788-2790)tCt>tTt	p.S930F		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	930						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AGAGTGCTCTCTGCCCTGGCA	0.642000													27	58					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89160066	89160066	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89160066G>A	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA																							AGACAATAGTGAAAAATTACT	0.368000													16	41					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43252892	43252892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43252892G>A	ENST00000255226.6	+	17	3073	c.2257G>A	c.(2257-2259)Ggc>Agc	p.G753S	RP11-116O18.3_ENST00000589510.1_RNA|SLC14A2_ENST00000586448.1_Missense_Mutation_p.G753S|SLC14A2_ENST00000589658.1_Missense_Mutation_p.G230S	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	753						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CGTTGGAATTGGCCAAGTGTA	0.478000													31	100					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26465770	26465770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:26465770C>T	ENST00000265944.5	+	31	4600	c.4434C>T	c.(4432-4434)ctC>ctT	p.L1478L	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1478					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGCAGTGCCTCTCAGGTAAAA	0.388000													17	67					0	0	1	0	0
NCAPG2	54892	broad.mit.edu	37	7	158472759	158472759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:158472759G>A	ENST00000409339.3	-	11	1152	c.1039C>T	c.(1039-1041)Cga>Tga	p.R347*	NCAPG2_ENST00000409423.1_Nonsense_Mutation_p.R347*|NCAPG2_ENST00000275830.10_Nonsense_Mutation_p.R139*|NCAPG2_ENST00000449727.2_Nonsense_Mutation_p.R347*|NCAPG2_ENST00000356309.3_Nonsense_Mutation_p.R347*			Q86XI2	CNDG2_HUMAN	non-SMC condensin II complex, subunit G2	347					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	39	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		GCATTTGATCGAACTTCAGAG	0.363000													14	114					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7242219	7242219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7242219C>T	ENST00000542285.1	-	4	681	c.532G>A	c.(532-534)Ggc>Agc	p.G178S				P00736	C1R_HUMAN	complement component 1, r subcomponent	179	EGF-like; calcium-binding (Potential).				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGCTCATAGCCTGGACGGCAG	0.602000													23	93					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839269	15839269	+	Missense_Mutation	SNP	G	G	A	rs142766169	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15839269G>A	ENST00000305899.3	+	1	436	c.416G>A	c.(415-417)cGg>cAg	p.R139Q		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					ATGAGCCCACGGGGCTGCGCC	0.632000													25	63					0	0	1	0	0
LOC643711	643711	broad.mit.edu	37	12	98126997	98126997	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:98126997C>T	ENST00000550548.1	-	0	261					NR_077240.1																						CCTTGAATATCTTCCACTGCA	0.468000													12	17					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156642586	156642586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156642586G>A	ENST00000368223.3	-	4	1526	c.1394C>T	c.(1393-1395)tCc>tTc	p.S465F		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	465	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGTGCCAAGGAGGCATGGTC	0.627000													44	104					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121391559	121391559	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:121391559G>A	ENST00000260197.7	+	9	1533		c.e9+1		SORL1_ENST00000532451.1_Splice_Site	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing						cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CAATTGTGAGGTATTGATGCT	0.398000													11	24					0	0	1	0	0
MNS1	55329	broad.mit.edu	37	15	56726525	56726525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:56726525C>T	ENST00000260453.3	-	8	1244	c.1080G>A	c.(1078-1080)ttG>ttA	p.L360L	TEX9_ENST00000352903.2_Intron|TEX9_ENST00000537232.1_Intron	NM_018365.2	NP_060835.1	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	360	Glu-rich.				meiosis					breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	20				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		CTAATTCCTTCAAGGCCATTT	0.338000													24	83					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133670172	133670172	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:133670172G>A	ENST00000310926.4	-	6	1014	c.741C>T	c.(739-741)gtC>gtT	p.V247V	SLCO2A1_ENST00000493729.1_Silent_p.V171V	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	247					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GGTCACCCGGGACCAAGTTAA	0.483000													29	62					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85989562	85989562	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:85989562C>T	ENST00000263360.6	+	12	2007	c.1321C>T	c.(1321-1323)Cga>Tga	p.R441*	EED_ENST00000327320.4_3'UTR|EED_ENST00000527888.1_Nonsense_Mutation_p.R106*|EED_ENST00000351625.6_Nonsense_Mutation_p.R466*|EED_ENST00000528180.1_Nonsense_Mutation_p.R361*	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	441	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GGATCGACTTCGATAAAATAC	0.383000													20	55					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43413570	43413570	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43413570C>T	ENST00000244533.3	+	13	3539	c.3180C>T	c.(3178-3180)tcC>tcT	p.S1060S	ABCC10_ENST00000372530.4_Silent_p.S1088S	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	1088	ABC transmembrane type-1 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			ACAGGGCCTCCTCACGGGAGC	0.667000													22	59					0	0	1	0	0
ENTPD2	954	broad.mit.edu	37	9	139944953	139944953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139944953G>A	ENST00000355097.2	-	6	859	c.812C>T	c.(811-813)tCc>tTc	p.S271F	ENTPD2_ENST00000312665.5_Missense_Mutation_p.S271F	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	271						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CACTTGGGTGGAAAAGCCCCT	0.642000											OREG0019627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	22					0	0	1	0	0
TRIM24	8805	broad.mit.edu	37	7	138252230	138252230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:138252230C>T	ENST00000343526.4	+	10	1750	c.1535C>T	c.(1534-1536)cCg>cTg	p.P512L	TRIM24_ENST00000415680.2_Missense_Mutation_p.P478L|TRIM24_ENST00000497516.1_3'UTR			O15164	TIF1A_HUMAN	tripartite motif containing 24	512					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						TTCTAGCAACCGCCTCCACGT	0.348000													46	122					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103471420	103471420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103471420C>T	ENST00000358392.2	-	18	2172	c.1855G>A	c.(1855-1857)Ggt>Agt	p.G619S	COL11A1_ENST00000512756.1_Missense_Mutation_p.G491S|COL11A1_ENST00000461720.1_5'UTR|COL11A1_ENST00000353414.4_Missense_Mutation_p.G568S|COL11A1_ENST00000370096.3_Missense_Mutation_p.G607S	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	607	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCTGGCAGACCCGGAAGTCCA	0.363000													23	123					0	0	1	0	0
TRBV7-7	28591	broad.mit.edu	37	7	142120058	142120058	+	RNA	SNP	C	C	T	rs141013676	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142120058C>T	ENST00000390377.1	-	0	108																											AGAGTTACATCCTGTCCCCTC	0.468000													7	56					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3174736	3174736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:3174736C>T	ENST00000355072.5	+	31	4189	c.4044C>T	c.(4042-4044)tcC>tcT	p.S1348S		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1348					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TTGGCTCCTCCAGTGTGAGGC	0.587000													31	80					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27455990	27455990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:27455990G>A	ENST00000337929.3	+	6	1108	c.635G>A	c.(634-636)gGg>gAg	p.G212E	IL21R_ENST00000564089.1_Missense_Mutation_p.G212E|IL21R_ENST00000564583.1_3'UTR|IL21R_ENST00000395755.1_Missense_Mutation_p.G212E|IL21R_ENST00000395754.4_Missense_Mutation_p.G212E	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	212					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						TCCTACCAGGGGACCTGGAGT	0.582000			T	BCL6	NHL								21	86					0	0	1	0	0
TESC	54997	broad.mit.edu	37	12	117494630	117494630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117494630G>A	ENST00000335209.7	-	3	376	c.190C>T	c.(190-192)Cgt>Tgt	p.R64C	TESC_ENST00000392545.4_Missense_Mutation_p.R117C|TESC_ENST00000541210.1_Intron			Q96BS2	TESC_HUMAN	tescalcin	64					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		AAGAAGGCACGAACAATTTTG	0.507000													57	32					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79434686	79434686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:79434686G>A	ENST00000554719.1	+	11	2511	c.2020G>A	c.(2020-2022)Gaa>Aaa	p.E674K	NRXN3_ENST00000335750.5_Missense_Mutation_p.E674K	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCGTGGCTGTGAAGGTACAAC	0.517000													25	47					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71690162	71690162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71690162C>T	ENST00000356340.3	+	28	2040	c.1504C>T	c.(1504-1506)Cgc>Tgc	p.R502C	COL13A1_ENST00000517713.1_Missense_Mutation_p.R480C|COL13A1_ENST00000398973.3_Missense_Mutation_p.R502C|COL13A1_ENST00000398972.3_Missense_Mutation_p.R502C|COL13A1_ENST00000357811.3_Missense_Mutation_p.R480C|COL13A1_ENST00000398966.3_Missense_Mutation_p.R480C|COL13A1_ENST00000522165.1_Missense_Mutation_p.R483C|COL13A1_ENST00000398971.3_Missense_Mutation_p.R502C|COL13A1_ENST00000520133.1_Missense_Mutation_p.R451C|COL13A1_ENST00000520267.1_Missense_Mutation_p.R445C|COL13A1_ENST00000398968.3_Missense_Mutation_p.R483C|COL13A1_ENST00000398978.3_Missense_Mutation_p.R502C|COL13A1_ENST00000398974.3_Missense_Mutation_p.R490C|COL13A1_ENST00000398964.3_Missense_Mutation_p.R473C|COL13A1_ENST00000354547.3_Missense_Mutation_p.R480C|COL13A1_ENST00000398969.3_Missense_Mutation_p.R445C			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	502	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AAAGGGACCTCGCGGTAAACC	0.537000													11	25					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214178524	214178524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:214178524C>T	ENST00000366958.4	+	3	2350	c.1742C>T	c.(1741-1743)tCa>tTa	p.S581L	PROX1_ENST00000498508.2_Missense_Mutation_p.S581L|PROX1_ENST00000435016.1_Missense_Mutation_p.S581L|PROX1_ENST00000261454.4_Missense_Mutation_p.S581L	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	581					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAAGGATTGTCACCCAATCAC	0.463000													24	64					0	0	1	0	0
AK1	203	broad.mit.edu	37	9	130630338	130630338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130630338G>A	ENST00000373176.1	-	7	686	c.534C>T	c.(532-534)tcC>tcT	p.S178S	AK1_ENST00000223836.10_Silent_p.S194S|RP11-203J24.9_ENST00000476274.2_RNA|AK1_ENST00000373156.1_Silent_p.S178S	NM_000476.2	NP_000467.1	P00568	KAD1_HUMAN	adenylate kinase 1	178					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding			endometrium(1)|prostate(1)	2						CACTGTCCACGGAGCCCTCAG	0.672000													27	51					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55860969	55860969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55860969C>T	ENST00000302124.2	+	1	217	c.186C>T	c.(184-186)ttC>ttT	p.F62F	OR8I2_ENST00000560768.1_Silent_p.F62F			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					TGTACTTTTTCCTGAGCAATT	0.383000													49	243					0	0	1	0	0
R3HDML	140902	broad.mit.edu	37	20	42969866	42969866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42969866G>A	ENST00000217043.2	+	2	464	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K		NM_178491.2	NP_848586.1	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like	98						extracellular region	peptidase inhibitor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)	21		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CAGGGCTGCCGAAGCCTGGGC	0.587000													21	49					0	0	1	0	0
KLHDC1	122773	broad.mit.edu	37	14	50210498	50210498	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:50210498C>T	ENST00000359332.2	+	12	1099	c.1009C>T	c.(1009-1011)Caa>Taa	p.Q337*	KLHDC1_ENST00000554512.1_3'UTR	NM_172193.2	NP_751943.1	Q8N7A1	KLDC1_HUMAN	kelch domain containing 1	337						cytoplasm				kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	12	all_epithelial(31;0.00244)|Breast(41;0.00964)					ATTGATCTTTCAAACACAGCC	0.259000													15	46					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134992588	134992588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:134992588C>T	ENST00000535938.1	+	16	2046	c.1879C>T	c.(1879-1881)Cac>Tac	p.H627Y	SAGE1_ENST00000537770.1_Missense_Mutation_p.H251Y|SAGE1_ENST00000370709.3_Missense_Mutation_p.H627Y|SAGE1_ENST00000324447.3_Missense_Mutation_p.H627Y	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	627										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					TGCAGTCACTCACAACATCCG	0.483000													27	51					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156378652	156378652	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:156378652G>A	ENST00000274532.2	-	3	606	c.550C>T	c.(550-552)Cag>Tag	p.Q184*	TIMD4_ENST00000407087.3_Nonsense_Mutation_p.Q184*	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	184	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTGTCATCTGGAGTGGTGTT	0.552000													39	125					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11300809	11300809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11300809C>T	ENST00000397056.1	+	3	277	c.86C>T	c.(85-87)cCc>cTc	p.P29L	HRH1_ENST00000431010.2_Missense_Mutation_p.P29L|HRH1_ENST00000438284.2_Missense_Mutation_p.P29L	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	29					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	CAGCTGATGCCCCTGGTGGTG	0.587000													13	31					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070360	9070360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9070360C>T	ENST00000397910.4	-	3	17289	c.17086G>A	c.(17086-17088)Gag>Aag	p.E5696K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5698	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCAGTCTCTCCTGTGTGGGG	0.502000													20	55					0	0	1	0	0
RPL4	6124	broad.mit.edu	37	15	66795835	66795835	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:66795835G>A	ENST00000307961.6	-	2	128	c.36C>T	c.(34-36)tcC>tcT	p.S12S	RPL4_ENST00000568588.1_5'UTR	NM_000968.3	NP_000959.2	P36578	RL4_HUMAN	ribosomal protein L4	12					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)|urinary_tract(1)	17						CCCCCTTTTCGGAGTACACCG	0.428000													14	57					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	53975609	53975609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53975609C>T	ENST00000312233.2	-	8	2016	c.1450G>A	c.(1450-1452)Ggg>Agg	p.G484R		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	484	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GGCTGGCCCCCCGGAGAATGG	0.692000													3	14					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	327976	327976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:327976G>A	ENST00000264819.4	-	4	267	c.257C>T	c.(256-258)cCc>cTc	p.P86L	MIER2_ENST00000592722.1_5'UTR	NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCATCAAAGGGCATGTCGTT	0.617000													14	20					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420813	53420813	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:53420813G>A	ENST00000377942.3	-	1	1962	c.1759C>T	c.(1759-1761)Cct>Tct	p.P587S	PCDH8_ENST00000338862.4_Missense_Mutation_p.P587S	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	587	Cadherin 5.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GAAAGCTGAGGGGAGCCGCCG	0.652000													4	14					0	0	1	0	0
EMID1	129080	broad.mit.edu	37	22	29630153	29630153	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:29630153G>A	ENST00000334018.6	+	11	1182	c.994G>A	c.(994-996)Gga>Aga	p.G332R	EMID1_ENST00000404755.3_Intron|EMID1_ENST00000404820.3_Missense_Mutation_p.G332R	NM_001267895.1|NM_133455.3	NP_001254824.1|NP_597712.2	Q96A84	EMID1_HUMAN	EMI domain containing 1	330	Collagen-like.					collagen				NS(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(2)|skin(3)	12						TGGACCCAAAGGAATCTCTGG	0.642000													5	12					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152319619	152319619	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:152319619C>T	ENST00000243326.4	+	29	4068	c.3585C>T	c.(3583-3585)ttC>ttT	p.F1195F	RIF1_ENST00000428287.2_Silent_p.F1195F|RIF1_ENST00000430328.2_Silent_p.F1195F|RIF1_ENST00000453091.2_Silent_p.F1195F|RIF1_ENST00000444746.2_Silent_p.F1195F			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1195					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AAAATTCTTTCGTTGTCAGCA	0.368000													37	75					0	0	1	0	0
CARD10	29775	broad.mit.edu	37	22	37892456	37892456	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37892456C>T	ENST00000403299.1	-	14	2275	c.2059_splice	c.e14+1	p.A687_splice	CARD10_ENST00000251973.5_Splice_Site_p.A687_splice|CARD10_ENST00000406271.3_Splice_Site_p.A401_splice			Q9BWT7	CAR10_HUMAN	caspase recruitment domain family, member 10	687					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					CCAGACTTACCCTTCGAGTCC	0.642000													12	38					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204588113	204588113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204588113C>T	ENST00000367175.1	-	1	3220	c.1008G>A	c.(1006-1008)caG>caA	p.Q336Q	LRRN2_ENST00000367176.3_Silent_p.Q336Q|LRRN2_ENST00000367177.3_Silent_p.Q336Q			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	336					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GGGTCTCCATCTGGGGCAGGT	0.612000													6	26					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167284402	167284402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:167284402C>T	ENST00000409855.1	-	17	2875	c.2749G>A	c.(2749-2751)Gga>Aga	p.G917R		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	917					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CAGATTTTTCCTTTCTTGGAT	0.408000													11	47					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301489	11301489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11301489C>T	ENST00000397056.1	+	3	957	c.766C>T	c.(766-768)Ccc>Tcc	p.P256S	HRH1_ENST00000431010.2_Missense_Mutation_p.P256S|HRH1_ENST00000438284.2_Missense_Mutation_p.P256S	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	256					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GAAGGAGTCTCCCTGGGAGGT	0.527000													20	34					0	0	1	0	0
ACAP1	9744	broad.mit.edu	37	17	7245290	7245290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7245290C>T	ENST00000158762.3	+	3	341	c.135C>T	c.(133-135)ctC>ctT	p.L45L		NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	45	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						GCACTGGTCTCCTGGAAAGTG	0.612000													30	51					0	0	1	0	0
DDX55	57696	broad.mit.edu	37	12	124090660	124090660	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124090660T>A	ENST00000238146.4	+	3	250	c.200T>A	c.(199-201)aTc>aAc	p.I67N	DDX55_ENST00000538744.1_Missense_Mutation_p.I67N	NM_020936.1	NP_065987.1	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	67	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		GTCATCCCCATCCTGGAAATT	0.423000													13	46					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140389325	140389325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140389325G>A	ENST00000532602.1	+	4	3689	c.2656G>A	c.(2656-2658)Gac>Aac	p.D886N	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Missense_Mutation_p.D872N|PCDHA6_ENST00000529310.1_Missense_Mutation_p.D886N|PCDHA7_ENST00000525929.1_Missense_Mutation_p.D873N|PCDHA8_ENST00000531613.1_Missense_Mutation_p.D886N|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Missense_Mutation_p.D883N|PCDHA6_ENST00000527624.1_Missense_Mutation_p.D622N|PCDHAC2_ENST00000289269.5_Missense_Mutation_p.D943N|PCDHA12_ENST00000398631.2_Missense_Mutation_p.D877N|PCDHAC1_ENST00000253807.2_Missense_Mutation_p.D899N|PCDHA10_ENST00000506939.2_Missense_Mutation_p.D621N|PCDHA10_ENST00000307360.5_Missense_Mutation_p.D884N|PCDHA1_ENST00000504120.2_Missense_Mutation_p.D886N|PCDHA11_ENST00000398640.2_Missense_Mutation_p.D885N|PCDHA13_ENST00000289272.2_Missense_Mutation_p.D886N|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Missense_Mutation_p.D886N|PCDHA1_ENST00000394633.3_Missense_Mutation_p.D622N|PCDHA2_ENST00000526136.1_Missense_Mutation_p.D884N	NM_031857.1	NP_114063.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGTTGCCCGACAAATTCAT	0.507000													8	97					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284752	52284752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52284752C>T	ENST00000301190.6	+	5	1249	c.1022C>T	c.(1021-1023)tCc>tTc	p.S341F	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Missense_Mutation_p.S216F|ANKRD33_ENST00000538991.1_Missense_Mutation_p.S147F	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	216										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CGAAGCAAGTCCGTGCCAGAG	0.662000													10	27					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126153184	126153184	+	Missense_Mutation	SNP	G	G	A	rs141942694	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126153184G>A	ENST00000393425.1	+	15	1690	c.1591G>A	c.(1591-1593)Gag>Aag	p.E531K	CCDC37_ENST00000352312.1_Missense_Mutation_p.E530K|CCDC37_ENST00000506204.1_3'UTR|CCDC37_ENST00000505024.1_Missense_Mutation_p.E531K			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	530										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		GGTCAAGATCGAGCAGGCCGA	0.637000													14	53					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55910724	55910724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55910724G>A	ENST00000388975.3	-	5	585	c.469C>T	c.(469-471)Cgc>Tgc	p.R157C		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	157					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ACGTGGACGCGAGAATCATGG	0.398000													9	13					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169940013	169940013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:169940013C>T	ENST00000327239.4	+	6	1992	c.488C>T	c.(487-489)tCc>tTc	p.S163F	DHRS9_ENST00000428522.1_Missense_Mutation_p.S163F|DHRS9_ENST00000421653.1_Missense_Mutation_p.S16F|DHRS9_ENST00000412271.1_Missense_Mutation_p.S163F|DHRS9_ENST00000602501.1_Missense_Mutation_p.S163F|DHRS9_ENST00000436483.2_Missense_Mutation_p.S163F|DHRS9_ENST00000357546.2_Missense_Mutation_p.S163F|DHRS9_ENST00000432060.2_Missense_Mutation_p.S223F	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	163					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						ATTAATGTCTCCAGTGTTGGA	0.418000													31	90					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48349722	48349722	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48349722G>A	ENST00000435803.1	+	24	9524	c.9500G>A	c.(9499-9501)cGa>cAa	p.R3167Q		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3167					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTGGATGTGCGAGCTTTCATT	0.512000													86	197					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170011071	170011071	+	Missense_Mutation	SNP	C	C	T	rs147817392		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:170011071C>T	ENST00000263816.3	-	66	12479	c.12194G>A	c.(12193-12195)cGa>cAa	p.R4065Q		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4065					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATTATATTTTCGAATTCGGAC	0.378000													16	93					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67109377	67109377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67109377G>A	ENST00000284425.2	-	15	2201	c.2027C>T	c.(2026-2028)gCt>gTt	p.A676V		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	676	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CAGGATGTCAGCCTCATCCAT	0.483000													15	55					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55077389	55077389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55077389G>A	ENST00000302250.2	-	6	990	c.830C>T	c.(829-831)tCg>tTg	p.S277L	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Missense_Mutation_p.S277L	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	277						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CATGGGGTCCGAGGCAGCCTG	0.592000													29	98					0	0	1	0	0
PGAP3	93210	broad.mit.edu	37	17	37844115	37844115	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37844115G>A	ENST00000300658.4	-	1	245	c.153C>T	c.(151-153)tcC>tcT	p.S51S	PGAP3_ENST00000579146.1_Silent_p.S51S|PGAP3_ENST00000378011.4_Silent_p.S51S|PGAP3_ENST00000429199.2_Silent_p.S51S	NM_033419.3	NP_219487.3	Q96FM1	PGAP3_HUMAN	post-GPI attachment to proteins 3	51					GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12						TTGGCTGGCGGGAGCGGAAGT	0.652000													4	6					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123489863	123489863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123489863C>T	ENST00000280562.5	-	6	1081	c.876G>A	c.(874-876)ggG>ggA	p.G292G	PITPNM2_ENST00000320201.4_Silent_p.G292G|PITPNM2_ENST00000546049.1_Silent_p.G292G|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Silent_p.G292G			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	292					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CTAGGGGCTCCCCATTGCTGC	0.647000													26	52					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11078583	11078583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11078583C>T	ENST00000287766.4	+	16	2152	c.1731C>T	c.(1729-1731)atC>atT	p.I577I	SLC6A1_ENST00000536032.1_Silent_p.I399I	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	577				I -> T (in Ref. 1; CAA38484).	neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	GCGAAGACATCGTTCGCCCAG	0.632000													30	71					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112145801	112145801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112145801G>A	ENST00000412145.1	-	18	4444	c.1891C>T	c.(1891-1893)Ccc>Tcc	p.P631S	PTPN3_ENST00000446349.1_Missense_Mutation_p.P586S|PTPN3_ENST00000394827.3_Missense_Mutation_p.P230S|PTPN3_ENST00000262539.3_Missense_Mutation_p.P608S|PTPN3_ENST00000374541.2_Missense_Mutation_p.P762S	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	762					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						ATGACGTCGGGGGGATCTGGC	0.557000													21	92					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43606198	43606198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:43606198G>A	ENST00000360835.3	-	19	2558	c.2432C>T	c.(2431-2433)tCc>tTc	p.S811F		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	811	CUB.				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GTAGTTGGGGGACTCGATGTA	0.652000													14	36					0	0	1	0	0
CCDC121	79635	broad.mit.edu	37	2	27850325	27850325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27850325C>T	ENST00000324364.3	-	2	522	c.342G>A	c.(340-342)aaG>aaA	p.K114K	RP11-158I13.2_ENST00000505973.1_RNA|CCDC121_ENST00000394775.3_Silent_p.K276K|ZNF512_ENST00000556601.1_Intron	NM_024584.4	NP_078860.2	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121	114										breast(1)|endometrium(3)|large_intestine(2)|lung(6)|prostate(2)	14	Acute lymphoblastic leukemia(172;0.155)					CCTGCTTTTCCTTTAATATAG	0.433000													90	230					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281937	152281937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152281937C>T	ENST00000368799.1	-	3	5460	c.5425G>A	c.(5425-5427)Ggt>Agt	p.G1809S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1809	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGTCCTGACCCTCTTGGGAC	0.597000									Ichthyosis				128	543					0	0	1	0	0
FBXO43	286151	broad.mit.edu	37	8	101153442	101153442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101153442G>A	ENST00000428847.2	-	2	1356	c.1040C>T	c.(1039-1041)tCc>tTc	p.S347F		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	347					meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			GTCAGACAGGGAATCTTCTGA	0.443000													40	91					0	0	1	0	0
NACA2	342538	broad.mit.edu	37	17	59668441	59668441	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59668441G>A	ENST00000521764.1	-	1	122	c.101C>T	c.(100-102)tCa>tTa	p.S34L		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	34					protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					CCCTGGTACTGATTCACCACT	0.542000													36	86					0	0	1	0	0
ACD	65057	broad.mit.edu	37	16	67694195	67694195	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67694195G>A	ENST00000219251.8	-	1	518	c.187C>T	c.(187-189)Ccg>Tcg	p.P63S	ACD_ENST00000393919.4_Missense_Mutation_p.P63S	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	63					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCTTTCCTCGGAAGAGGAAGC	0.741000													5	35					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23926680	23926680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:23926680C>T	ENST00000402377.3	-	4	1813	c.1672G>A	c.(1672-1674)Gga>Aga	p.G558R	ZNF681_ENST00000395385.3_Missense_Mutation_p.G489R	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				GGTTTCTCTCCAGTATGAATT	0.398000													9	107					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41554252	41554252	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41554252T>G	ENST00000396942.1	-	25	2760	c.2677A>C	c.(2677-2679)Agc>Cgc	p.S893R	ANK1_ENST00000289734.7_Missense_Mutation_p.S893R|ANK1_ENST00000347528.4_Missense_Mutation_p.S893R|ANK1_ENST00000379758.2_Missense_Mutation_p.S893R|ANK1_ENST00000352337.4_Missense_Mutation_p.S893R|ANK1_ENST00000265709.8_Missense_Mutation_p.S934R|ANK1_ENST00000396945.1_Missense_Mutation_p.S893R			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	893					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGGCCGGGCTGCTGGGGATG	0.647000													15	27					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156622703	156622703	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:156622703C>T	ENST00000361588.5	+	8	2002	c.1961C>T	c.(1960-1962)tCa>tTa	p.S654L	BCAN_ENST00000329117.4_Intron|RP11-284F21.7_ENST00000448869.1_RNA	NM_198427.1	NP_940819.1	Q96GW7	PGCB_HUMAN	brevican	418	EGF-like.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCCAAGGCTCAACTGCCCTC	0.597000													68	103					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874038	36874038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36874038C>T	ENST00000301807.6	-	21	7151	c.5254G>A	c.(5254-5256)Gag>Aag	p.E1752K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E2302K|TRANK1_ENST00000428977.2_Missense_Mutation_p.E1752K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2302					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TTTTCAAACTCCTCCGGGTAG	0.527000													27	59					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10084865	10084865	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10084865G>A	ENST00000264828.3	-	47	3571	c.3486C>T	c.(3484-3486)gtC>gtT	p.V1162V		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1162	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CGACGTCTCCGACCTCCCCTT	0.592000													26	52					0	0	1	0	0
KITLG	4254	broad.mit.edu	37	12	88910219	88910219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:88910219C>T	ENST00000347404.5	-	5	984	c.412G>A	c.(412-414)Gaa>Aaa	p.E138K	KITLG_ENST00000357116.4_Intron|KITLG_ENST00000228280.5_Missense_Mutation_p.E138K|KITLG_ENST00000378535.4_5'UTR	NM_003994.5	NP_003985.2	P21583	SCF_HUMAN	KIT ligand	138					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)	9						AAGAATTCTTCAGGAGTAAAG	0.343000									Testicular Cancer, Familial Clustering of				12	68					0	0	1	0	0
POP4	10775	broad.mit.edu	37	19	30099604	30099604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30099604C>T	ENST00000392279.3	+	2	69	c.29C>T	c.(28-30)aCt>aTt	p.T10I	POP4_ENST00000591824.1_3'UTR|POP4_ENST00000585603.1_Silent_p.D16D|POP4_ENST00000221770.3_5'UTR			O95707	RPP29_HUMAN	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)	0					mRNA cleavage|rRNA processing|tRNA processing	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease P activity|RNA binding			breast(1)|endometrium(1)|lung(4)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			AGGCGAATGACTCCGATGTCC	0.483000													11	127					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115341723	115341723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115341723G>A	ENST00000351270.3	+	9	1023	c.927G>A	c.(925-927)agG>agA	p.R309R	HABP2_ENST00000542051.1_Silent_p.R283R|HABP2_ENST00000541666.1_Intron	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	309					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		TAGCAGAGAGGAAGATCAAGA	0.572000													45	122					0	0	1	0	0
TMEM177	80775	broad.mit.edu	37	2	120438714	120438714	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:120438714C>T	ENST00000424086.1	+	2	758	c.285C>T	c.(283-285)ttC>ttT	p.F95F	TMEM177_ENST00000401466.1_Silent_p.F95F|TMEM177_ENST00000409951.1_Intron|TMEM177_ENST00000496203.1_Intron|TMEM177_ENST00000272521.6_Silent_p.F95F	NM_001105198.1	NP_001098668.1	Q53S58	TM177_HUMAN	transmembrane protein 177	95						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	13	Colorectal(110;0.196)					GTGCAGGCTTCCCAAGACTCC	0.547000													111	235					0	0	1	0	0
EXD2	55218	broad.mit.edu	37	14	69702850	69702850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:69702850C>T	ENST00000409014.1	+	8	1419	c.762C>T	c.(760-762)taC>taT	p.Y254Y	EXD2_ENST00000312994.5_Silent_p.Y379Y|EXD2_ENST00000449989.1_Silent_p.Y254Y|EXD2_ENST00000492815.1_3'UTR|EXD2_ENST00000409018.3_Silent_p.Y379Y|EXD2_ENST00000409675.1_Silent_p.Y254Y|EXD2_ENST00000409242.1_Silent_p.Y254Y|EXD2_ENST00000409949.1_Silent_p.Y254Y	NM_001193360.1	NP_001180289.1	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	254					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						CTCAGTGGTACCTGGACAAAG	0.468000													9	137					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086625	100086625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100086625C>T	ENST00000423930.1	+	4	1440	c.1281C>T	c.(1279-1281)tcC>tcT	p.S427S	NYAP1_ENST00000454988.1_Silent_p.S370S|NYAP1_ENST00000300179.2_Silent_p.S427S			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	427	Pro-rich.																TCCCCAACTCCCACAGCATGA	0.746000													7	7					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50958925	50958925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50958925C>T	ENST00000374103.4	-	7	941	c.856G>A	c.(856-858)Gag>Aag	p.E286K	OGDHL_ENST00000419399.1_Missense_Mutation_p.E229K|OGDHL_ENST00000432695.1_Missense_Mutation_p.E77K	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	286					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						ATCCCCATCTCGCTGGATTTG	0.582000													5	25					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35910613	35910613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35910613C>T	ENST00000397367.2	-	3	296	c.170G>A	c.(169-171)cGa>cAa	p.R57Q	CAPSL_ENST00000514524.1_Missense_Mutation_p.R57Q|CAPSL_ENST00000397366.1_Missense_Mutation_p.R57Q	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	57	EF-hand 1.					cytoplasm	calcium ion binding	p.R57Q(1)		central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			ATCAAGGGTTCGATTATTATC	0.308000													15	49					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169697037	169697037	+	Silent	SNP	C	C	T	rs144324234	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:169697037C>T	ENST00000333360.7	-	9	1450	c.1311G>A	c.(1309-1311)ccG>ccA	p.P437P	SELE_ENST00000367780.4_Silent_p.P312P|SELE_ENST00000367781.4_Silent_p.P374P|SELE_ENST00000367779.4_Intron|SELE_ENST00000367782.4_Intron|SELE_ENST00000367777.1_Intron|SELE_ENST00000367775.1_Silent_p.P312P|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367776.1_Silent_p.P374P|SELE_ENST00000367774.1_Intron	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	437	Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					CCAAACCCTTCGGGGGCTGGT	0.488000													29	90					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228886491	228886491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228886491C>T	ENST00000392056.3	-	6	679	c.633G>A	c.(631-633)gaG>gaA	p.E211E	SPHKAP_ENST00000344657.5_Silent_p.E211E	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	211						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GAAAGTCTTCCTCGATTGAAG	0.473000													24	82					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31901450	31901450	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31901450A>T	ENST00000456570.1	+	3	375	c.320A>T	c.(319-321)cAt>cTt	p.H107L	C2_ENST00000299367.5_Missense_Mutation_p.H169L|C2_ENST00000452323.2_Missense_Mutation_p.H46L|C2_ENST00000442278.2_Missense_Mutation_p.H37L|C2_ENST00000469372.1_Start_Codon_SNP_p.M1L|CFB_ENST00000477310.1_Intron|CFB_ENST00000556679.1_Missense_Mutation_p.H107L|C2_ENST00000418949.2_Missense_Mutation_p.H169L			P00751	CFAB_HUMAN	complement factor B	183	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CGCTTTGGTCATGGGGACAAG	0.632000													24	70					0	0	1	0	0
C6orf15	29113	broad.mit.edu	37	6	31079984	31079984	+	Missense_Mutation	SNP	G	G	A	rs139732921		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31079984G>A	ENST00000259870.3	-	2	155	c.152C>T	c.(151-153)tCc>tTc	p.S51F		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	51										endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						GCCAGTGGAGGAAGGTTGTCC	0.567000													37	98					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197102708	197102708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197102708G>A	ENST00000367409.4	-	6	2447	c.2191C>T	c.(2191-2193)Ctt>Ttt	p.L731F	ASPM_ENST00000294732.7_Missense_Mutation_p.L731F|ASPM_ENST00000367408.1_5'UTR	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	731					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						ATTCCCAAAAGAAGAGTAGCA	0.338000													12	44					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46825952	46825952	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46825952G>A	ENST00000283296.7	-	17	3976	c.3688C>T	c.(3688-3690)Ctc>Ttc	p.L1230F	GPR116_ENST00000456426.2_Missense_Mutation_p.L1088F|GPR116_ENST00000265417.7_Missense_Mutation_p.L1230F|GPR116_ENST00000545669.1_Missense_Mutation_p.L659F|GPR116_ENST00000362015.4_Missense_Mutation_p.L1230F	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1230					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			CCCCAAGTGAGGCCCAAGAGT	0.507000													41	97					0	0	1	0	0
GPR52	9293	broad.mit.edu	37	1	174417609	174417609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:174417609C>T	ENST00000367685.2	+	1	398	c.360C>T	c.(358-360)atC>atT	p.I120I	RABGAP1L_ENST00000357444.6_Intron|RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000251507.4_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	120						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						TTGGATATATCATCTCAGTTC	0.428000													84	195					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961968	34961968	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:34961968G>A	ENST00000329357.5	+	1	1056	c.1020G>A	c.(1018-1020)cgG>cgA	p.R340R		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	340										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						ACACTCATCGGGTGTCCAGTT	0.587000													32	15					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184099748	184099748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:184099748C>T	ENST00000204604.1	+	6	885	c.639C>T	c.(637-639)ttC>ttT	p.F213F	EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000482805.1_3'UTR|CHRD_ENST00000348986.3_Silent_p.F213F|CHRD_ENST00000450923.1_Silent_p.F213F	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	213	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGATCCGCTTCTCAGACTCCA	0.612000													14	28					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803538	142803538	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:142803538G>A	ENST00000423385.1	-	0	1427																											ATAGATGTTGGAATTCCTGAT	0.269000													18	288					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922731	24922731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922731C>T	ENST00000329468.2	+	1	2191	c.1717C>T	c.(1717-1719)Cct>Tct	p.P573S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TGCGGTAGACCCTGAAGTAGT	0.463000													39	87					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43319621	43319621	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43319621G>A	ENST00000321925.4	+	8	1172	c.940G>A	c.(940-942)Ggc>Agc	p.G314S	SLC14A1_ENST00000586142.1_Missense_Mutation_p.G314S|SLC14A1_ENST00000502059.2_Missense_Mutation_p.G206S|RP11-116O18.3_ENST00000586213.1_RNA|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000436407.3_Missense_Mutation_p.G370S|SLC14A1_ENST00000415427.3_Missense_Mutation_p.G370S|SLC14A1_ENST00000535474.1_Missense_Mutation_p.G182S|SLC14A1_ENST00000402943.2_Missense_Mutation_p.G209S|SLC14A1_ENST00000589700.1_Silent_p.L264L|SLC14A1_ENST00000591541.1_Missense_Mutation_p.G18S	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	314						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						CCTGGCTCTTGGCTGTGGTGA	0.537000													23	64					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165378827	165378827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:165378827G>A	ENST00000359842.5	-	7	1316	c.1014C>T	c.(1012-1014)gcC>gcT	p.A338A		NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	338	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CAGCACTGTGGGCACTGCTCC	0.522000													13	29					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13584380	13584380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:13584380C>T	ENST00000606117.1	+	3	334	c.38C>T	c.(37-39)tCc>tTc	p.S13F	SIRT5_ENST00000359782.3_Missense_Mutation_p.S13F|SIRT5_ENST00000397350.2_5'UTR|SIRT5_ENST00000379262.4_Missense_Mutation_p.S13F	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	13					chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	CGATTGATTTCCCAGCTATAT	0.453000													45	103					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160100331	160100331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:160100331C>T	ENST00000361216.3	+	13	1860	c.1771C>T	c.(1771-1773)Cct>Tct	p.P591S	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Missense_Mutation_p.P591S	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	591					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TATGATTGACCCTCCCCGGGC	0.577000													26	75					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86416107	86416107	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86416107C>T	ENST00000361669.2	+	3	2098	c.999C>T	c.(997-999)ttC>ttT	p.F333F	GRM3_ENST00000394720.2_Silent_p.F331F|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Silent_p.F333F|GRM3_ENST00000536043.1_Silent_p.F205F	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	333					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TCCGCCAGTTCGACCGCTACT	0.627000													17	25					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793396	29793396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29793396G>A	ENST00000269202.6	+	11	1500	c.1453G>A	c.(1453-1455)Gat>Aat	p.D485N	MEP1B_ENST00000581447.1_Missense_Mutation_p.D485N	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	485	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TGGAGCCAATGATGATCAATT	0.408000													17	27					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36940286	36940286	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36940286C>T	ENST00000262865.4	+	5	648	c.559C>T	c.(559-561)Caa>Taa	p.Q187*	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	187					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				GTGGCTGATCCAACTCTTCCA	0.498000													10	92					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879555	3879555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:3879555C>T	ENST00000315677.3	-	4	1109	c.514G>A	c.(514-516)Gag>Aag	p.E172K	DLGAP1-AS3_ENST00000577649.1_RNA|DLGAP1_ENST00000581527.1_Missense_Mutation_p.E172K|DLGAP1_ENST00000515196.2_Missense_Mutation_p.E172K|DLGAP1_ENST00000584874.1_Missense_Mutation_p.E172K	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	172					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.E172K(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GCCTGCGCCTCGTCAGGGCTG	0.711000													36	108					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168807887	168807887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:168807887C>T	ENST00000464456.1	-	13	3911	c.2711G>A	c.(2710-2712)gGa>gAa	p.G904E	MECOM_ENST00000433243.2_Missense_Mutation_p.G914E|MECOM_ENST00000472280.1_Missense_Mutation_p.G914E|MECOM_ENST00000392736.3_Missense_Mutation_p.G913E|MECOM_ENST00000494292.1_Missense_Mutation_p.G1092E|MECOM_ENST00000468789.1_Missense_Mutation_p.G913E|MECOM_ENST00000264674.3_Missense_Mutation_p.G978E|MECOM_ENST00000460814.1_Missense_Mutation_p.G904E	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TGGTTCCTTTCCTGTTTTTCC	0.428000													64	149					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9010979	9010979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:9010979G>A	ENST00000344836.4	-	7	953	c.755C>T	c.(754-756)tCg>tTg	p.S252L	USP7_ENST00000381886.4_Missense_Mutation_p.S236L|USP7_ENST00000535863.1_Missense_Mutation_p.S153L	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	252					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						GCTTTTAGACGAATCATCCCC	0.358000													47	96					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53547816	53547816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53547816G>A	ENST00000371500.3	+	12	2253	c.1912G>A	c.(1912-1914)Gaa>Aaa	p.E638K	PODN_ENST00000312553.5_Missense_Mutation_p.E657K|PODN_ENST00000395871.2_Missense_Mutation_p.E515K|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	609					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ggaggaggaggaagaggaAAC	0.522000													14	19					0	0	1	0	0
CHEK1	1111	broad.mit.edu	37	11	125513759	125513759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:125513759C>T	ENST00000534070.1	+	9	1142	c.887C>T	c.(886-888)tCc>tTc	p.S296F	CHEK1_ENST00000438015.1_Missense_Mutation_p.S296F|CHEK1_ENST00000427383.2_Missense_Mutation_p.S312F|CHEK1_ENST00000428830.2_Missense_Mutation_p.S296F|CHEK1_ENST00000532449.1_3'UTR|CHEK1_ENST00000278916.3_Missense_Mutation_p.S296F|CHEK1_ENST00000524737.1_Missense_Mutation_p.S296F|CHEK1_ENST00000544373.1_Missense_Mutation_p.S296F	NM_001274.5	NP_001265.2	O14757	CHK1_HUMAN	checkpoint kinase 1	296					cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|endometrium(3)|large_intestine(2)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	26	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		CACATTCAATCCAATTTGGAC	0.383000								Other conserved DNA damage response genes					17	54					0	0	1	0	0
ARHGDIG	398	broad.mit.edu	37	16	332780	332780	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:332780G>A	ENST00000219409.3	+	6	719	c.644G>A	c.(643-645)tGg>tAg	p.W215*		NM_001176.3	NP_001167.2	Q99819	GDIR3_HUMAN	Rho GDP dissociation inhibitor (GDI) gamma	215					negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity			breast(1)|central_nervous_system(1)|large_intestine(1)	3		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				TCCTGGGAGTGGGGTCTCTGC	0.652000											OREG0003697	type=REGULATORY REGION|Gene=PDIA2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	10					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	130982538	130982538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130982538G>A	ENST00000341179.7	+	6	859	c.767G>A	c.(766-768)cGa>cAa	p.R256Q	DNM1_ENST00000393594.3_Missense_Mutation_p.R256Q|DNM1_ENST00000475805.1_Missense_Mutation_p.R256Q|DNM1_ENST00000372923.3_Missense_Mutation_p.R256Q|DNM1_ENST00000486160.1_Missense_Mutation_p.R256Q	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	256					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity	p.R256L(2)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						GCTGCTGAACGAAAGTTCTTC	0.547000													61	100					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35993899	35993899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:35993899G>A	ENST00000297866.5	+	15	2648	c.2582G>A	c.(2581-2583)cGa>cAa	p.R861Q		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	861										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TTGAGACCACGAGGCTTCTTC	0.433000													54	84					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2442268	2442268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:2442268C>T	ENST00000452833.1	-	3	467	c.459G>A	c.(457-459)gaG>gaA	p.E153E	TRPM5_ENST00000155858.6_Silent_p.E153E|TRPM5_ENST00000533060.1_Silent_p.E153E|TRPM5_ENST00000528453.1_Silent_p.E153E			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	153						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCACCTGGGCCTCCTCCAGAA	0.701000													3	1					0	0	1	0	0
HOXD9	3235	broad.mit.edu	37	2	176988257	176988257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:176988257C>T	ENST00000249499.6	+	1	1170	c.761C>T	c.(760-762)tCg>tTg	p.S254L	HOXD-AS2_ENST00000440016.2_RNA	NM_014213.3	NP_055028.3	P28356	HXD9_HUMAN	homeobox D9	254						nucleus	sequence-specific DNA binding			endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CCAGGCTGTTCGCTGAAGGAG	0.627000													13	14					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3139136	3139136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3139136G>A	ENST00000252463.2	-	5	2221	c.2134C>T	c.(2134-2136)Ctg>Ttg	p.L712L	ZSCAN10_ENST00000575108.1_Silent_p.L373L|ZSCAN10_ENST00000538082.2_Silent_p.L630L	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	712					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						TGGCGCAGCAGGTGGGAGTTG	0.711000													5	10					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36179516	36179516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36179516C>T	ENST00000303965.4	-	9	2279	c.1790G>A	c.(1789-1791)aGa>aAa	p.R597K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	597	PH 2.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTTATAGCCTCTCAATTCAAG	0.398000													17	100					0	0	1	0	0
FBXO22	26263	broad.mit.edu	37	15	76205550	76205550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:76205550C>T	ENST00000308275.3	+	3	391	c.286C>T	c.(286-288)Cgc>Tgc	p.R96C	FBXO22_ENST00000540507.1_5'UTR|FBXO22_ENST00000453211.2_Missense_Mutation_p.R96C	NM_147188.2	NP_671717.1	Q8NEZ5	FBX22_HUMAN	F-box protein 22	96					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						GCAGAATGTTCGCATCTTACC	0.383000													19	110					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161116026	161116026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:161116026G>A	ENST00000523217.1	+	4	509	c.267G>A	c.(265-267)gaG>gaA	p.E89E	GABRA6_ENST00000274545.5_Silent_p.E99E|RP11-348M17.2_ENST00000521984.1_RNA	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	99					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGCCAACTGAGATTCTGAGTC	0.413000										TCGA Ovarian(5;0.080)			33	108					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38296443	38296443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:38296443C>T	ENST00000553443.1	+	29	5170	c.5170C>T	c.(5170-5172)Cat>Tat	p.H1724Y	TTC6_ENST00000267368.7_Missense_Mutation_p.H358Y|TTC6_ENST00000382320.3_Missense_Mutation_p.H438Y|TTC6_ENST00000476979.1_Missense_Mutation_p.H358Y					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		TGGGGTGATTCATGAGTTTAT	0.363000													38	81					0	0	1	0	0
SYT7	9066	broad.mit.edu	37	11	61291963	61291963	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:61291963G>A	ENST00000263846.4	-	6	991	c.664C>T	c.(664-666)Caa>Taa	p.Q222*	SYT7_ENST00000535826.1_Nonsense_Mutation_p.Q341*|SYT7_ENST00000540831.1_5'UTR|SYT7_ENST00000542836.1_Nonsense_Mutation_p.Q266*|SYT7_ENST00000542670.1_Nonsense_Mutation_p.Q430*|SYT7_ENST00000539008.1_Nonsense_Mutation_p.Q505*|SYT7_ENST00000540677.1_Nonsense_Mutation_p.Q297*	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	222	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TCCAGGACTTGGAGGTAGAGG	0.587000													6	58					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51133180	51133180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51133180C>T	ENST00000338916.4	-	3	1556	c.923G>A	c.(922-924)cGg>cAg	p.R308Q	SYT3_ENST00000600079.1_Missense_Mutation_p.R308Q|SYT3_ENST00000544769.1_Missense_Mutation_p.R308Q|SYT3_ENST00000593901.1_Missense_Mutation_p.R308Q	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	308	C2 1.					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity	p.R308Q(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		ATAGAGGTACCGCAGGGCGAA	0.672000													8	105					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219123	67219123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67219123G>A	ENST00000312457.2	-	1	1077	c.1073C>T	c.(1072-1074)cCt>cTt	p.P358L		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	358						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GTTCACCTGAGGCTGGGCCAC	0.627000													22	38					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67380160	67380160	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67380160G>A	ENST00000329956.6	+	3	219	c.198_splice	c.e3-1	p.G67_splice	LRRC36_ENST00000563303.1_3'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	67										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TCCTTGTAGGGAATCCAGTAT	0.358000													24	74					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22134151	22134151	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22134151C>T	ENST00000408935.1	+	1	855	c.855C>T	c.(853-855)ttC>ttT	p.F285F		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TGAATCCCTTCATTTACACCT	0.453000													16	71					0	0	1	0	0
FKBP6	8468	broad.mit.edu	37	7	72742623	72742623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72742623G>A	ENST00000252037.4	+	2	172	c.103G>A	c.(103-105)Gac>Aac	p.D35N	FKBP6_ENST00000413573.2_Missense_Mutation_p.D35N|FKBP6_ENST00000431982.2_Missense_Mutation_p.D30N	NM_003602.3	NP_003593.3	O75344	FKBP6_HUMAN	FK506 binding protein 6, 36kDa	35					protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	16		Lung NSC(55;0.0908)|all_lung(88;0.198)				CATCTCGGGGGACCGGGGCGT	0.632000													9	41					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43625187	43625187	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43625187G>A	ENST00000405006.4	-	29	4501	c.4150C>T	c.(4150-4152)Cga>Tga	p.R1384*	THADA_ENST00000330266.7_Intron|THADA_ENST00000485353.1_5'UTR|THADA_ENST00000415080.2_Nonsense_Mutation_p.R1065*|THADA_ENST00000405975.2_Nonsense_Mutation_p.R1384*	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1384							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AACAGAGTTCGAATGGTATTA	0.493000													50	73					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50111267	50111267	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:50111267C>T	ENST00000281631.5	+	15	1735	c.1575_splice	c.e15-1	p.P526_splice	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505554.1_Splice_Site_p.P505_splice|PARP8_ENST00000503750.2_Splice_Site_p.P526_splice|PARP8_ENST00000514342.2_Splice_Site_p.P279_splice|PARP8_ENST00000505697.2_Splice_Site_p.P526_splice|PARP8_ENST00000514067.2_Splice_Site_p.P526_splice	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	526						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				CTTTTGTAGCCTACCGTATGT	0.358000													14	59					0	0	1	0	0
OR2T34	127068	broad.mit.edu	37	1	248737532	248737532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248737532G>A	ENST00000328782.2	-	1	548	c.527C>T	c.(526-528)tCt>tTt	p.S176F		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATTTTCCTAGACTGGCAAAA	0.527000													43	82					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9100123	9100123	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9100123C>T	ENST00000377424.4	-	6	876	c.697_splice	c.e6+1	p.A233_splice	SLC2A5_ENST00000536305.1_Splice_Site_p.A174_splice|SLC2A5_ENST00000535586.1_Splice_Site_p.A118_splice	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	233					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCCTCGTTACCTTTCTTGGCG	0.687000													8	26					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3342631	3342631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3342631G>A	ENST00000378398.3	+	15	3208	c.3126G>A	c.(3124-3126)ggG>ggA	p.G1042G	PRDM16_ENST00000378391.2_Silent_p.G1042G|PRDM16_ENST00000442529.2_Silent_p.G1041G|PRDM16_ENST00000441472.2_Silent_p.G1041G|PRDM16_ENST00000514189.1_Silent_p.G1042G|PRDM16_ENST00000511072.1_Silent_p.G1043G|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Silent_p.G1042G			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	1042	Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGCACCCCGGGGTCCTCACGA	0.637000			T	EVI1	"""MDS, AML"""								17	29					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36714235	36714235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36714235G>A	ENST00000244751.2	-	16	1762	c.1138C>T	c.(1138-1140)Cct>Tct	p.P380S	CPNE5_ENST00000393189.2_Missense_Mutation_p.P88S|CPNE5_ENST00000459703.1_5'UTR	NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	380	VWFA.									central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CCCAGGGCAGGGAACATCTTG	0.627000													17	86					0	0	1	0	0
SOCS7	30837	broad.mit.edu	37	17	36521282	36521282	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:36521282C>T	ENST00000577233.1	+	4	1050	c.1050C>T	c.(1048-1050)ccC>ccT	p.P350P	SOCS7_ENST00000331159.5_Intron	NM_014598.2	NP_055413.1	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	350	Mediates interaction with SORBS3.|Poly-Pro.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			central_nervous_system(1)|endometrium(1)|kidney(1)|prostate(1)|skin(5)	9	Breast(7;3.47e-17)					CTCCTCCACCCCATGCCCCAG	0.493000													13	20					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124840115	124840115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:124840115G>A	ENST00000356219.3	-	25	3420	c.3265C>T	c.(3265-3267)Cac>Tac	p.H1089Y	NCOR2_ENST00000404121.2_Missense_Mutation_p.H643Y|NCOR2_ENST00000405201.1_Missense_Mutation_p.H1082Y|NCOR2_ENST00000404621.1_Missense_Mutation_p.H1072Y|NCOR2_ENST00000429285.2_Missense_Mutation_p.H1072Y|NCOR2_ENST00000397355.1_Missense_Mutation_p.H1073Y	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1090					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGCAGTGGGTGACCTGTGGAG	0.677000													10	12					0	0	1	0	0
KRTAP5-9	3846	broad.mit.edu	37	11	71260054	71260054	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71260054C>T	ENST00000528743.2	+	1	589	c.351C>T	c.(349-351)tcC>tcT	p.S117S		NM_005553.3	NP_005544.4	P26371	KRA59_HUMAN	keratin associated protein 5-9	117	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament				kidney(1)|large_intestine(1)|lung(6)|prostate(3)	11						CCTGTTGCTCCTCCTCGGGTC	0.622000													61	168					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16168605	16168605	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:16168605C>T	ENST00000380289.2	+	2	989	c.591C>T	c.(589-591)gcC>gcT	p.A197A		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	197					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					TTAGCTGTGCCCCATACCCAC	0.488000													72	43					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150445091	150445091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:150445091C>T	ENST00000401000.4	+	10	3654	c.3589C>T	c.(3589-3591)Cat>Tat	p.H1197Y	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.H1223Y			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1223	Pro-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TCCTAAGGATCATGGTGGTAT	0.572000													36	101					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9052063	9052063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:9052063G>A	ENST00000382496.5	-	20	3432	c.2767C>T	c.(2767-2769)Ctg>Ttg	p.L923L		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	923	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						ATGGGGAACAGGAGGATGCAC	0.587000													14	38					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8478937	8478937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:8478937C>T	ENST00000447869.1	-	5	1566	c.648G>A	c.(646-648)agG>agA	p.R216R	STK33_ENST00000396673.1_Silent_p.R216R|STK33_ENST00000315204.1_Silent_p.R216R|STK33_ENST00000396672.1_Silent_p.R216R|STK33_ENST00000358872.3_Silent_p.R29R|STK33_ENST00000534493.1_Silent_p.R175R			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	216	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		GAATGATCCACCTTGTCTCAT	0.393000													23	66					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208270	58208270	+	Silent	SNP	G	G	A	rs151242806	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:58208270G>A	ENST00000377918.3	+	1	1616	c.1590G>A	c.(1588-1590)acG>acA	p.T530T		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	530	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGAATCCCACGAACGGGGCCA	0.587000													16	66					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21481174	21481174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:21481174G>A	ENST00000313654.9	+	48	6329	c.6088G>A	c.(6088-6090)Gaa>Aaa	p.E2030K	LAMA3_ENST00000587184.1_Missense_Mutation_p.E365K|LAMA3_ENST00000399516.3_Missense_Mutation_p.E1974K|LAMA3_ENST00000269217.6_Missense_Mutation_p.E421K|LAMA3_ENST00000588770.1_3'UTR	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2030	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCTTTAAATGAATACGAAGC	0.507000													23	49					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31606074	31606074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:31606074C>T	ENST00000170150.3	+	8	782	c.587C>T	c.(586-588)cCc>cTc	p.P196L		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	196						extracellular region	lipid binding										GGCCTCAACCCCGTGGGTCCT	0.478000													18	73					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55572982	55572982	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55572982G>A	ENST00000294383.6	-	40	4691	c.4692C>T	c.(4690-4692)atC>atT	p.I1564I	USP24_ENST00000407756.1_Silent_p.I1404I	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1564					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CTGCCAGTAAGATGTTGTCCG	0.463000													11	66					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21789388	21789388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21789388C>T	ENST00000328843.6	+	54	8818	c.8787C>T	c.(8785-8787)ttC>ttT	p.F2929F	DNAH11_ENST00000409508.3_Silent_p.F2922F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2929	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATGAGAGCTTCCTCGTGCTGA	0.438000									Kartagener syndrome				20	45					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469120	72469120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:72469120C>T	ENST00000296776.5	+	1	99	c.50C>T	c.(49-51)tCc>tTc	p.S17F	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	17						integral to membrane		p.S17F(1)		endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		AATGTGTTCTCCGTCACTCCT	0.577000													33	264					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150723772	150723772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150723772C>T	ENST00000335244.4	-	2	350	c.221G>A	c.(220-222)gGa>gAa	p.G74E	SLC36A2_ENST00000521967.1_Missense_Mutation_p.G74E	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	74					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGGGGTAGTCCCAGGATCCC	0.552000													6	58					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15989593	15989593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15989593C>T	ENST00000221700.5	-	13	1646	c.1551G>A	c.(1549-1551)gaG>gaA	p.E517E	CYP4F2_ENST00000592328.1_Silent_p.E517E	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	517					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AGCTCAGGGGCTCCACCCGCA	0.607000													15	33					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207297708	207297708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207297708G>A	ENST00000367070.3	+	6	897	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	235	Sushi 3.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TCCTACCTGTGAAAGTAAGTC	0.418000													15	51					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39821156	39821156	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:39821156G>A	ENST00000502986.2	+	3	410	c.168G>A	c.(166-168)tgG>tgA	p.W56*	RP11-44K6.3_ENST00000517623.1_RNA|IDO2_ENST00000389060.4_Nonsense_Mutation_p.W43*|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	43					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						ATAGGCCTTGGATGGAAATTG	0.398000													6	16					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84474551	84474551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:84474551G>A	ENST00000416219.2	+	14	1387	c.1298G>A	c.(1297-1299)gGa>gAa	p.G433E	ATP2C2_ENST00000262429.4_Missense_Mutation_p.G433E|ATP2C2_ENST00000420010.2_3'UTR			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	433					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						GTCTCAGTGGGAAAGTTAGTG	0.493000													7	16					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78799654	78799654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:78799654G>A	ENST00000545128.1	+	17	2801	c.2263G>A	c.(2263-2265)Gaa>Aaa	p.E755K	PCSK5_ENST00000376752.4_Missense_Mutation_p.E755K	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	755	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TAACTGTACAGAATGTAGGGA	0.338000													22	23					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17012086	17012086	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17012086G>A	ENST00000443236.1	-	36	4879	c.4848C>T	c.(4846-4848)tcC>tcT	p.S1616S		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1569						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CAGCCATATTGGAAGACCCTG	0.637000													4	21					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837712	82837712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82837712G>A	ENST00000265077.3	+	8	9455	c.8890G>A	c.(8890-8892)Gat>Aat	p.D2964N	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.D1977N|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2964	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TACAACTGCCGATGAAATTGA	0.463000													61	147					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27529141	27529141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27529141G>A	ENST00000296098.4	+	8	1323	c.1053G>A	c.(1051-1053)atG>atA	p.M351I	TRIM54_ENST00000380075.2_Missense_Mutation_p.M309I	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	309					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGAGAGCATGGAGCAATTCA	0.652000													17	51					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44449852	44449852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:44449852C>T	ENST00000360029.3	-	1	972	c.689G>A	c.(688-690)cGg>cAg	p.R230Q		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	230						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CGCCACACGCCGGAATTTGGC	0.721000										HNSCC(17;0.042)			5	10					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861330	55861330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55861330C>T	ENST00000302124.2	+	1	578	c.547C>T	c.(547-549)Ctt>Ttt	p.L183F	OR8I2_ENST00000560768.1_Missense_Mutation_p.L183F			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L183F(1)		NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					CACCACAGCTCTTTTAGCACT	0.438000													51	165					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36091374	36091374	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:36091374G>A	ENST00000378660.1	+	4	497	c.309G>A	c.(307-309)aaG>aaA	p.K103K	CHDC2_ENST00000313548.4_Silent_p.K103K					calponin homology domain containing 2																		AAGGAACAAAGGCACACTACT	0.408000													51	50					0	0	1	0	0
C15orf26	161502	broad.mit.edu	37	15	81427637	81427637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81427637G>A	ENST00000286732.4	+	2	179	c.96G>A	c.(94-96)aaG>aaA	p.K32K		NM_173528.2	NP_775799.2	Q6P656	CO026_HUMAN	chromosome 15 open reading frame 26	32										endometrium(1)|kidney(4)|large_intestine(5)|lung(6)|skin(1)	17						TCTTAGAGAAGAGAGACAAGG	0.323000													18	113					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	77006657	77006657	+	Silent	SNP	G	G	A	rs138204887	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:77006657G>A	ENST00000257626.7	-	9	705	c.627C>T	c.(625-627)ttC>ttT	p.F209F		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		GAGCCCAAACGAAATCCTCAG	0.303000													31	244					0	0	1	0	0
POLR2E	5434	broad.mit.edu	37	19	1090119	1090119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:1090119G>A	ENST00000215587.7	-	5	738	c.455C>T	c.(454-456)aCc>aTc	p.T152I	POLR2E_ENST00000585838.1_5'UTR|POLR2E_ENST00000586746.1_Missense_Mutation_p.T152I			P19388	RPAB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	152					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|skin(2)	11		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCTCCTTGGTCATGACGAC	0.662000													11	35					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142605896	142605896	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142605896A>C	ENST00000265310.1	-	15	2322	c.1974T>G	c.(1972-1974)gaT>gaG	p.D658E		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	658					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCTCCTGGTCATCCTCCTTGT	0.537000													13	59					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111164350	111164350	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:111164350C>T	ENST00000360467.5	+	48	5257	c.4951C>T	c.(4951-4953)Cgc>Tgc	p.R1651C		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1651	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGAGGACTTCCGCGCCACACC	0.617000													33	69					0	0	1	0	0
THEM5	284486	broad.mit.edu	37	1	151820663	151820663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151820663G>A	ENST00000368817.5	-	4	701	c.570C>T	c.(568-570)ttC>ttT	p.F190F	AL450992.2_ENST00000434182.1_RNA	NM_182578.3	NP_872384.1	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	190							hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTTACTTTTTGAACCTGATGT	0.562000													37	106					0	0	1	0	0
HSF5	124535	broad.mit.edu	37	17	56565478	56565478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56565478G>A	ENST00000323777.3	-	1	267	c.158C>T	c.(157-159)cCg>cTg	p.P53L		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	53						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					cggcccgggcgggcTGAGCAG	0.721000													5	12					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30024934	30024934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:30024934G>A	ENST00000346128.6	-	14	2296	c.1822C>T	c.(1822-1824)Cgc>Tgc	p.R608C	TJP1_ENST00000400011.2_Missense_Mutation_p.R612C|TJP1_ENST00000545208.2_Missense_Mutation_p.R608C|TJP1_ENST00000356107.6_Missense_Mutation_p.R608C	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	608	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TTGGAGCTGCGAAGACCTCTG	0.473000													16	65					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5011051	5011051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5011051C>T	ENST00000380390.1	+	3	489	c.273C>T	c.(271-273)tcC>tcT	p.S91S	MMP26_ENST00000477339.1_3'UTR|MMP26_ENST00000300762.1_Silent_p.S91S			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	91					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCGACACCTCCATCTCGCCAG	0.517000													20	50					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	101013182	101013182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:101013182G>A	ENST00000284382.4	-	10	1108	c.685C>T	c.(685-687)Cgc>Tgc	p.R229C	CERS3_ENST00000394113.1_Missense_Mutation_p.R229C|CERS3_ENST00000560944.1_Intron|CERS3_ENST00000538112.2_Missense_Mutation_p.R229C	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	229	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GTCCCACTGCGAATATAATTA	0.438000													15	156					0	0	1	0	0
TXNRD2	10587	broad.mit.edu	37	22	19865928	19865928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:19865928G>A	ENST00000400519.1	-	15	1304	c.1305C>T	c.(1303-1305)ttC>ttT	p.F435F	TXNRD2_ENST00000400525.1_Silent_p.F413F|TXNRD2_ENST00000542719.1_Silent_p.F406F|TXNRD2_ENST00000400518.1_Silent_p.F406F|TXNRD2_ENST00000535882.1_Silent_p.F435F|TXNRD2_ENST00000400521.1_Silent_p.F436F			Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2	436					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|urinary_tract(2)	30	Colorectal(54;0.0993)					CAGCCACCGTGAACTCCAGTG	0.562000													78	170					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31332892	31332892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31332892G>A	ENST00000544665.3	+	16	2020	c.1949G>A	c.(1948-1950)gGa>gAa	p.G650E	ITGAM_ENST00000287497.8_Missense_Mutation_p.G649E	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	649					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						AAGGAAGCCGGAGAGGTCAGA	0.512000													51	122					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62070963	62070963	+	Silent	SNP	G	G	A	rs118192212		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62070963G>A	ENST00000354587.3	-	6	1091	c.915C>T	c.(913-915)ttC>ttT	p.F305F	KCNQ2_ENST00000357249.2_Silent_p.F305F|KCNQ2_ENST00000370222.3_Silent_p.F305F|KCNQ2_ENST00000344462.3_Silent_p.F305F|KCNQ2_ENST00000359125.2_Silent_p.F305F|KCNQ2_ENST00000344425.5_Silent_p.F305F|KCNQ2_ENST00000370224.1_Silent_p.F305F|KCNQ2_ENST00000370226.1_Silent_p.F305F|KCNQ2_ENST00000360480.3_Silent_p.F305F|KCNQ2_ENST00000370221.1_Silent_p.F305F|KCNQ2_ENST00000359689.1_Silent_p.F305F|KCNQ2_ENST00000430658.1_Silent_p.F305F			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	305					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CAGGCAGCGCGAAGAAGGAGA	0.632000													26	96					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83770408	83770408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:83770408C>T	ENST00000398309.2	-	6	1024	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	DLG2_ENST00000524982.1_Missense_Mutation_p.R185Q|DLG2_ENST00000543673.1_Missense_Mutation_p.R290Q|DLG2_ENST00000418306.2_Missense_Mutation_p.R134Q|DLG2_ENST00000532653.1_Missense_Mutation_p.R185Q|DLG2_ENST00000398301.2_Missense_Mutation_p.R224Q|DLG2_ENST00000280241.8_Missense_Mutation_p.R224Q|DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000531015.1_Missense_Mutation_p.R152Q|DLG2_ENST00000330014.6_Missense_Mutation_p.R124Q|DLG2_ENST00000537455.1_5'UTR|DLG2_ENST00000376104.2_Missense_Mutation_p.R290Q	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	185						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CAAAATAGGTCGTCTTCTACG	0.458000													28	116					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15107640	15107640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15107640C>T	ENST00000378217.3	+	7	806	c.619C>T	c.(619-621)Cat>Tat	p.H207Y	OLAH_ENST00000485251.1_3'UTR|OLAH_ENST00000378228.3_Missense_Mutation_p.H154Y	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	154					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						ACAAATAAGTCATTACCTTAT	0.403000													15	51					0	0	1	0	0
MORN1	79906	broad.mit.edu	37	1	2288982	2288982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:2288982G>A	ENST00000378531.3	-	10	1098	c.925C>T	c.(925-927)Ccc>Tcc	p.P309S	MORN1_ENST00000606372.1_5'UTR|MORN1_ENST00000378529.3_Missense_Mutation_p.P309S	NM_024848.1	NP_079124.1	Q5T089	MORN1_HUMAN	MORN repeat containing 1	309										breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(1)|ovary(2)	9	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		GCAGCTCTGGGCCCCGGCACC	0.657000													37	101					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51192483	51192483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51192483C>T	ENST00000293441.1	-	15	2036	c.2018G>A	c.(2017-2019)gGg>gAg	p.G673E	SHANK1_ENST00000359082.3_Missense_Mutation_p.G664E|SHANK1_ENST00000391813.1_Missense_Mutation_p.G60E|SHANK1_ENST00000391814.1_Missense_Mutation_p.G673E	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	673	PDZ.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GAACCCAAACCCCTCACTGTC	0.612000													18	151					0	0	1	0	0
ENAH	55740	broad.mit.edu	37	1	225702509	225702509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:225702509G>A	ENST00000366844.2	-	7	1458	c.1007C>T	c.(1006-1008)cCc>cTc	p.P336L	ENAH_ENST00000284563.6_Missense_Mutation_p.P583L|ENAH_ENST00000366843.2_Missense_Mutation_p.P336L	NM_001008493.1	NP_001008493.1	Q8N8S7	ENAH_HUMAN	enabled homolog (Drosophila)	336	Pro-rich.				axon guidance|intracellular transport|T cell receptor signaling pathway	cytosol|filopodium|focal adhesion|lamellipodium|synapse	actin binding|SH3 domain binding|WW domain binding			NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.19)		aggtggagggggccctggggg	0.672000													7	14					0	0	1	0	0
ZNF788	388507	broad.mit.edu	37	19	12223856	12223856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12223856G>A	ENST00000339302.4	+	3	2131	c.1494G>A	c.(1492-1494)ggG>ggA	p.G498G	ZNF20_ENST00000600335.1_Intron|ZNF788_ENST00000397759.3_Silent_p.G117G|ZNF788_ENST00000430298.2_3'UTR					zinc finger family member 788											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	2						CTCACATTGGGGAGAAACCCT	0.418000													5	34					0	0	1	0	0
CXCL11	6373	broad.mit.edu	37	4	76956249	76956249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:76956249C>T	ENST00000306621.3	-	3	421	c.212G>A	c.(211-213)gGa>gAa	p.G71E	CXCL11_ENST00000503860.1_Missense_Mutation_p.G71E|ART3_ENST00000341029.5_Intron	NM_005409.4	NP_005400.1	O14625	CXL11_HUMAN	chemokine (C-X-C motif) ligand 11	71				NKGQ -> IRK (in Ref. 1; AAB17374).	cell-cell signaling|chemotaxis|inflammatory response|signal transduction	extracellular space	chemokine activity			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCATCGTTGTCCTTTATTTTC	0.328000													34	89					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768049	57768049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57768049C>T	ENST00000371030.2	+	1	1975	c.1975C>T	c.(1975-1977)Cct>Tct	p.P659S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	659						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					ACTGGGCTTTCCTCTGCAGAA	0.582000													20	62					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234769	21234769	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21234769C>T	ENST00000233242.1	-	26	5098	c.4971G>A	c.(4969-4971)acG>acA	p.T1657T		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1657					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAAGTTGGTCGTTGCACTGG	0.453000													16	56					0	0	1	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170315	20170315	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:20170315C>T	ENST00000338912.5	-	0	39																											CTACCTGCAGCTATGACCACC	0.542000													35	122					0	0	1	0	0
PRPSAP1	5635	broad.mit.edu	37	17	74328431	74328431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74328431G>A	ENST00000446526.3	-	4	821	c.376C>T	c.(376-378)Ccc>Tcc	p.P126S	PRPSAP1_ENST00000324684.4_Missense_Mutation_p.P23S	NM_002766.2	NP_002757.2	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 1	97					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17						GGGAAGTAGGGGATGACCCCA	0.517000													44	108					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53544406	53544406	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53544406G>A	ENST00000371500.3	+	10	1652	c.1311G>A	c.(1309-1311)gaG>gaA	p.E437E	PODN_ENST00000312553.5_Silent_p.E456E|PODN_ENST00000395871.2_Silent_p.E314E|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	408					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TCCTGGAGGAGCTCAACCTCA	0.657000													49	118					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17476457	17476457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17476457C>T	ENST00000252590.4	-	3	878	c.817G>A	c.(817-819)Gac>Aac	p.D273N		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	273						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGCATGTGGTCGCAGGCTCTG	0.637000													14	59					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606842	55606842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55606842C>T	ENST00000378396.1	+	1	615	c.615C>T	c.(613-615)gcC>gcT	p.A205A		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TCACTGTTGCCACTTTTAATG	0.423000													30	99					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95603935	95603935	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:95603935C>T	ENST00000343958.4	-	2	1348	c.1125G>A	c.(1123-1125)gtG>gtA	p.V375V	FGD6_ENST00000546711.1_Silent_p.V375V|FGD6_ENST00000549499.1_Silent_p.V375V	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	375					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						TCATTTTATCCACCTGTTCCT	0.353000													27	70					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29997796	29997796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:29997796C>T	ENST00000308893.4	+	16	3246	c.2203C>T	c.(2203-2205)Cag>Tag	p.Q735*	TAOK2_ENST00000543033.1_Nonsense_Mutation_p.Q735*|TAOK2_ENST00000416441.2_Nonsense_Mutation_p.Q562*|TAOK2_ENST00000279394.3_Nonsense_Mutation_p.Q735*	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	735					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GCATGCGGCCCAGGTTCGCCA	0.672000													39	127					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8621299	8621299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:8621299C>T	ENST00000429646.2	+	9	3531	c.738C>T	c.(736-738)ttC>ttT	p.F246F	CPZ_ENST00000360986.4_Silent_p.F638F|CPZ_ENST00000382480.2_Silent_p.F501F|CPZ_ENST00000315782.6_Silent_p.F627F			Q66K79	CBPZ_HUMAN	carboxypeptidase Z	638					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GGTCCTACTTCACATCGCTGA	0.701000													9	33					0	0	1	0	0
RPL5	6125	broad.mit.edu	37	1	93301949	93301949	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:93301949G>A	ENST00000370321.3	+	5	617	c.527_splice	c.e5+1	p.S176_splice		NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5	176				S -> R (in Ref. 9).	endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		ATCCCTCACAGGTAAGAATAC	0.453000													21	54					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3422738	3422738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:3422738G>A	ENST00000356575.4	-	15	2078	c.1852C>T	c.(1852-1854)Cgg>Tgg	p.R618W	MEGF6_ENST00000294599.4_Missense_Mutation_p.R513W	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	618	EGF-like 11.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CGGTGGCACCGGCCCCGGTTG	0.652000													5	10					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63179424	63179424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:63179424G>A	ENST00000394968.1	-	11	2023	c.1856C>T	c.(1855-1857)tCc>tTc	p.S619F	KCNH5_ENST00000420622.2_Intron|KCNH5_ENST00000322893.7_Intron	NM_172376.1	NP_758964.1	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	0					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GTTTGCCATGGAGAACCATCC	0.502000													7	12					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153149867	153149867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153149867C>T	ENST00000285900.5	+	13	2505	c.2162C>T	c.(2161-2163)aCc>aTc	p.T721I	GRIA1_ENST00000518142.1_Missense_Mutation_p.T641I|GRIA1_ENST00000518783.1_Missense_Mutation_p.T731I|GRIA1_ENST00000521843.2_Missense_Mutation_p.T652I|GRIA1_ENST00000448073.4_Missense_Mutation_p.T731I|GRIA1_ENST00000340592.5_Missense_Mutation_p.T721I	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	721					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTGGAGTCCACCATGAATGAG	0.502000													15	47					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160016608	160016608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:160016608C>T	ENST00000327245.5	-	24	4587	c.3741G>A	c.(3739-3741)atG>atA	p.M1247I		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1247					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCATGTCTTCATTTCCATTG	0.443000													7	52					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304075	10304075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10304075C>T	ENST00000403437.2	-	27	3461	c.3367G>A	c.(3367-3369)Gaa>Aaa	p.E1123K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1123					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCGATTTCTTCCCCCAGCTCC	0.522000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				34	29					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154395724	154395724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:154395724G>A	ENST00000435029.4	+	1	2465	c.2305G>A	c.(2305-2307)Gaa>Aaa	p.E769K		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	769	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGACCTCCTTGAAGACAGAAA	0.453000													19	44					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8500768	8500768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:8500768C>T	ENST00000381196.4	-	21	2657	c.2114G>A	c.(2113-2115)cGa>cAa	p.R705Q	PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.R705Q|PTPRD_ENST00000360074.4_Missense_Mutation_p.R692Q|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.R692Q|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.R705Q|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000397606.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	705	Fibronectin type-III 4.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTCATTGGTTCGAATCAACAC	0.473000										TSP Lung(15;0.13)			41	64					0	0	1	0	0
IPCEF1	26034	broad.mit.edu	37	6	154533920	154533920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:154533920G>A	ENST00000265198.4	-	9	673	c.518C>T	c.(517-519)tCc>tTc	p.S173F	IPCEF1_ENST00000422970.2_Missense_Mutation_p.S174F|IPCEF1_ENST00000367220.4_Missense_Mutation_p.S174F|IPCEF1_ENST00000519091.1_5'UTR|OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000519344.1_Missense_Mutation_p.S145F	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						CTGAGTCTGGGAAGCGTGAGG	0.413000													15	28					0	0	1	0	0
MKNK1	8569	broad.mit.edu	37	1	47024335	47024335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47024335G>A	ENST00000371946.4	-	14	1473	c.1310C>T	c.(1309-1311)tCc>tTc	p.S437F	MKNK1_ENST00000371944.4_Missense_Mutation_p.S301F|MKNK1_ENST00000371945.4_Missense_Mutation_p.S396F|MKNK1-AS1_ENST00000602433.1_RNA|MKNK1_ENST00000341183.5_3'UTR	NM_003684.5	NP_003675.2	Q9BUB5	MKNK1_HUMAN	MAP kinase interacting serine/threonine kinase 1	437					intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	13	Acute lymphoblastic leukemia(166;0.155)					GCAGGGAGGGGAAAGCTTCAT	0.627000													22	36					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130492962	130492962	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130492962G>A	ENST00000373289.3	+	14	1980	c.1900G>A	c.(1900-1902)Gaa>Aaa	p.E634K	TTC16_ENST00000489226.1_3'UTR	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	634							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						TATCTGCCAGGAATACAGGAG	0.587000													7	37					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332737	71332737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:71332737G>A	ENST00000242462.4	-	2	92	c.63C>T	c.(61-63)ttC>ttT	p.F21F		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	21					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						AGGCTCTGGGGAAGGACCGCT	0.677000													22	62					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22941084	22941084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:22941084C>T	ENST00000397104.3	-	5	1353	c.1354G>A	c.(1354-1356)Ggc>Agc	p.G452S	ZNF99_ENST00000596209.1_Missense_Mutation_p.G543S					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAAGCTTTGCCACATTCTTCA	0.343000													17	72					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111470890	111470890	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111470890G>A	ENST00000265162.5	+	17	2691	c.2349G>A	c.(2347-2349)agG>agA	p.R783R		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	783					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TAAATCTCAGGCTTCTGGTGT	0.388000													18	104					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46245220	46245220	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46245220C>T	ENST00000296140.3	-	2	710	c.585G>A	c.(583-585)tgG>tgA	p.W195*	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	195					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GAAACAGCTTCCACTCTCGTA	0.468000													36	73					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9389741	9389741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:9389741G>A	ENST00000378501.2	+	20	1891	c.1876G>A	c.(1876-1878)Gga>Aga	p.G626R	PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000414679.2_Missense_Mutation_p.G638R|PLCB4_ENST00000278655.4_Missense_Mutation_p.G626R|PLCB4_ENST00000378493.1_Missense_Mutation_p.G626R|PLCB4_ENST00000334005.3_Missense_Mutation_p.G626R|PLCB4_ENST00000378473.3_Missense_Mutation_p.G638R	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	626	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TTACCCCAAGGGAGGCCGAGT	0.423000													11	31					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530609	140530609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140530609C>T	ENST00000231136.1	+	1	771	c.771C>T	c.(769-771)ggC>ggT	p.G257G	PCDHB6_ENST00000543635.1_Silent_p.G121G	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		257	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCCCCTCGGCTCTCTGGTTA	0.507000													15	43					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111154975	111154975	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111154975C>T	ENST00000280325.4	+	3	329	c.182C>T	c.(181-183)cCc>cTc	p.P61L		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	61										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CCCTACTTCCCCCAGGAGCCC	0.667000													44	86					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174673	207174673	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207174673C>A	ENST00000374423.3	+	5	5807	c.5421C>A	c.(5419-5421)gtC>gtA	p.V1807V		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1807							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CAAAGGATGTCATAGAGGATA	0.408000													29	48					3.57733e-08	3.58864e-08	1	1	0
CEACAM16	388551	broad.mit.edu	37	19	45209064	45209064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45209064G>A	ENST00000587331.1	+	5	1081	c.866G>A	c.(865-867)gGg>gAg	p.G289E	CEACAM16_ENST00000405314.2_Missense_Mutation_p.G289E|CTB-171A8.1_ENST00000590796.1_RNA	NM_001039213.2	NP_001034302.2	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 16	289										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				GCCCAGGAGGGGACGTACACA	0.587000													47	82					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7242285	7242285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7242285G>A	ENST00000542285.1	-	4	615	c.466C>T	c.(466-468)Ccc>Tcc	p.P156S				P00736	C1R_HUMAN	complement component 1, r subcomponent	157	EGF-like; calcium-binding (Potential).				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGGGGCTGGGGATCCTCCTCC	0.562000													23	40					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8212211	8212211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8212211C>T	ENST00000600128.1	-	2	568	c.154G>A	c.(154-156)Ggc>Agc	p.G52S	FBN3_ENST00000601739.1_Missense_Mutation_p.G52S|FBN3_ENST00000270509.2_Missense_Mutation_p.G52S			Q75N90	FBN3_HUMAN	fibrillin 3	52						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGCAAGATGCCTGGGCTGCCC	0.692000													4	10					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122551357	122551357	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:122551357G>A	ENST00000264357.5	+	11	1897	c.1605G>A	c.(1603-1605)aaG>aaA	p.K535K	GRIA3_ENST00000542149.1_Silent_p.K535K|GRIA3_ENST00000371256.5_Silent_p.K535K|GRIA3_ENST00000371251.1_Silent_p.K535K|GRIA3_ENST00000541091.1_Silent_p.K519K	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	535					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TCATGATAAAGAAGCCTCAGA	0.428000													87	63					0	0	1	0	0
GPR31	2853	broad.mit.edu	37	6	167570885	167570885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:167570885G>A	ENST00000366834.1	-	1	932	c.435C>T	c.(433-435)ctC>ctT	p.L145L		NM_005299.2	NP_005290.2	O00270	GPR31_HUMAN	G protein-coupled receptor 31	145						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(4)|large_intestine(4)|lung(7)|prostate(1)	17		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		CCGGGCAGGTGAGGGCGACCA	0.647000													25	42					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113920566	113920566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:113920566G>A	ENST00000348367.4	-	16	1752	c.1555C>T	c.(1555-1557)Cgt>Tgt	p.R519C	GPAM_ENST00000423155.1_Missense_Mutation_p.R519C|GPAM_ENST00000369425.1_Missense_Mutation_p.R519C			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	519					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TCAAAATCACGAGCCAGGACT	0.443000													8	37					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161119180	161119180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:161119180G>A	ENST00000523217.1	+	8	1272	c.1030G>A	c.(1030-1032)Gaa>Aaa	p.E344K	GABRA6_ENST00000274545.5_Missense_Mutation_p.E354K	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	354					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAAAGCTACTGAACCTTTGGA	0.413000										TCGA Ovarian(5;0.080)			29	94					0	0	1	0	0
TRABD2A	129293	broad.mit.edu	37	2	85097546	85097546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:85097546C>T	ENST00000335459.5	-	2	677	c.472G>A	c.(472-474)Gga>Aga	p.G158R	TRABD2A_ENST00000409520.2_Missense_Mutation_p.G158R|TRABD2A_ENST00000409133.1_Missense_Mutation_p.G158R	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		TCCCAGTTTCCGGCAATAGCA	0.562000													26	98					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75112979	75112979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75112979C>T	ENST00000309664.5	+	8	917	c.778C>T	c.(778-780)Ccc>Tcc	p.P260S	LMAN1L_ENST00000379709.3_Missense_Mutation_p.P248S	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	260						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCCCTAGGTTCCCCCTCAGCC	0.642000													40	183					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982421	36982421	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:36982421G>A	ENST00000274963.8	+	7	994		c.e7-1			NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2						actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						GCCCCTTTCAGAAGCCCTGGA	0.597000													16	38					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127668645	127668645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127668645C>T	ENST00000508053.1	-	38	5155	c.4181G>A	c.(4180-4182)aGc>aAc	p.S1394N	FBN2_ENST00000507835.1_Missense_Mutation_p.S244N|FBN2_ENST00000262464.4_Missense_Mutation_p.S1394N|FBN2_ENST00000508989.1_Missense_Mutation_p.S1361N			P35556	FBN2_HUMAN	fibrillin 2	1394	EGF-like 22; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTCTCTGCAGCTACACTTGAA	0.398000													50	192					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111861250	111861250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111861250G>A	ENST00000369740.1	+	9	968	c.865G>A	c.(865-867)Ggt>Agt	p.G289S	CHIA_ENST00000353665.6_Missense_Mutation_p.G128S|CHIA_ENST00000343320.6_Missense_Mutation_p.G289S|CHIA_ENST00000430615.1_Missense_Mutation_p.G181S|CHIA_ENST00000451398.2_Missense_Mutation_p.G128S|CHIA_ENST00000483391.1_Missense_Mutation_p.G128S|RP5-1125M8.2_ENST00000426321.1_RNA	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	289					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		CTCTGGTGCTGGTCCTGCTGG	0.537000													60	103					0	0	1	0	0
PSTPIP2	9050	broad.mit.edu	37	18	43591196	43591196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:43591196G>A	ENST00000409746.5	-	5	376	c.305C>T	c.(304-306)gCc>gTc	p.A102V	PSTPIP2_ENST00000589328.1_Missense_Mutation_p.A102V|PSTPIP2_ENST00000588801.1_5'UTR	NM_024430.3	NP_077748.3	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting protein 2	102						membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	17						CATCTTCCTGGCCTCTTCTCT	0.373000													75	218					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113565931	113565931	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113565931C>T	ENST00000546530.1	-	4	460	c.175G>A	c.(175-177)Gtg>Atg	p.V59M	RASAL1_ENST00000261729.5_Missense_Mutation_p.V59M|RASAL1_ENST00000548055.1_Missense_Mutation_p.V59M|RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000446861.3_Missense_Mutation_p.V59M	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	59	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						GGCAGGTGCACCGTGTACTCC	0.617000													90	228					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125282298	125282298	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125282298G>A	ENST00000340750.1	+	1	879	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						ATAGCCTAAGGAACAGGGACA	0.458000													23	52					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105169497	105169497	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105169497C>T	ENST00000392634.4	+	3	559	c.447C>T	c.(445-447)gcC>gcT	p.A149A	INF2_ENST00000330634.7_Silent_p.A149A|INF2_ENST00000398337.4_Silent_p.A149A	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	149	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TACTGGCTGCCCTGTGCATCT	0.652000													14	40					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431856	140431856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140431856G>A	ENST00000306549.3	+	1	878	c.801G>A	c.(799-801)gtG>gtA	p.V267V		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		267	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGACTGCCGTGGACCTAGACG	0.517000													9	38					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55210706	55210706	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:55210706C>T	ENST00000396834.1	+	16	2207	c.1711C>T	c.(1711-1713)Ccc>Tcc	p.P571S	IL31RA_ENST00000490985.1_Missense_Mutation_p.P448S|IL31RA_ENST00000354961.4_Missense_Mutation_p.P571S|IL31RA_ENST00000359040.5_Missense_Mutation_p.P590S|IL31RA_ENST00000447346.2_Missense_Mutation_p.P590S	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	558					anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GCCCACCGTTCCCAACCCTGC	0.428000													22	98					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61510285	61510285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:61510285G>A	ENST00000398571.2	-	37	5069	c.4993C>T	c.(4993-4995)Cct>Tct	p.P1665S		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1665					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			CTTACCTCAGGAATAAGGAGA	0.343000													25	69					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145393331	145393331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:145393331C>T	ENST00000511217.1	+	4	818	c.766C>T	c.(766-768)Ctt>Ttt	p.L256F	SH3RF2_ENST00000359120.4_Missense_Mutation_p.L256F			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	256							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGCAAGACACCTTTTAGAGAA	0.507000													11	89					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143098600	143098600	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143098600G>A	ENST00000275815.3	-	3	335	c.249C>T	c.(247-249)tcC>tcT	p.S83S		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	83						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				AGATCCAATTGGAGCGAAGCC	0.602000													61	219					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40945418	40945418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:40945418C>T	ENST00000313164.9	+	7	1045	c.686C>T	c.(685-687)tCa>tTa	p.S229L		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	229	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				AGATCTTCATCATCTTCTTCA	0.313000													10	25					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003723	122003723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:122003723C>T	ENST00000498619.1	+	7	3390	c.2952C>T	c.(2950-2952)acC>acT	p.T984T	CASR_ENST00000296154.5_Silent_p.T974T|CASR_ENST00000490131.1_Silent_p.T974T	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	974					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCACGGTCACCTTCTCACTGA	0.577000													15	45					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72036313	72036313	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:72036313G>A	ENST00000378743.3	-	6	1888	c.1530C>T	c.(1528-1530)tcC>tcT	p.S510S		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	510					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GCTTATCTAAGGATCGCCTCA	0.373000													42	146					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18763838	18763838	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:18763838G>A	ENST00000396170.1	-	7	1864	c.600C>T	c.(598-600)ctC>ctT	p.L200L	PTPN5_ENST00000396171.4_Silent_p.L232L|PTPN5_ENST00000396167.2_Silent_p.L200L|PTPN5_ENST00000358540.2_Silent_p.L232L|PTPN5_ENST00000477854.1_Silent_p.L36L|PTPN5_ENST00000496201.2_5'UTR|PTPN5_ENST00000396168.1_Silent_p.L208L	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	232						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						ACTTGACGGTGAGTGAGGTGG	0.592000													44	104					0	0	1	0	0
PILRB	29990	broad.mit.edu	37	7	99956641	99956641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99956641C>T	ENST00000444874.1	+	15	2084	c.184C>T	c.(184-186)Ccg>Tcg	p.P62S	PILRB_ENST00000310771.4_Silent_p.T131T|PILRB_ENST00000448382.1_Missense_Mutation_p.P184S|PILRB_ENST00000452089.1_Silent_p.T131T|PILRB_ENST00000444073.1_Silent_p.T131T			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	0	Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGCTGGACACCCGGAGATCAG	0.592000													39	70					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567206	45567206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:45567206G>A	ENST00000588982.1	-	3	774	c.273C>T	c.(271-273)ttC>ttT	p.F91F	ZBTB7C_ENST00000586438.1_Silent_p.F91F|ZBTB7C_ENST00000535628.2_Silent_p.F91F|ZBTB7C_ENST00000590800.1_Silent_p.F91F|ZBTB7C_ENST00000332053.2_Silent_p.F91F			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	91	BTB.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						AGGTGTAGGCGAACTCCAGGA	0.572000													22	49					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96781867	96781867	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:96781867G>T	ENST00000359933.4	-	22	4308	c.3415C>A	c.(3415-3417)Cgc>Agc	p.R1139S		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1139										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CAGTGTGGGCGGGTTGAGCTG	0.428000													8	43					3.09899e-07	3.10697e-07	1	1	0
MYL1	4632	broad.mit.edu	37	2	211163245	211163245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211163245G>A	ENST00000352451.3	-	3	350	c.203C>T	c.(202-204)tCc>tTc	p.S68F	MYL1_ENST00000341685.4_Missense_Mutation_p.S24F|MYL1_ENST00000496436.1_5'UTR	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	68	EF-hand 1.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GGTGATCTTGGAATCACCTGT	0.448000													35	59					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56922570	56922570	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:56922570G>A	ENST00000520220.2	+	13	1651	c.1377G>A	c.(1375-1377)tgG>tgA	p.W459*	LYN_ENST00000519728.1_Nonsense_Mutation_p.W480*	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	480	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			AAATGTGCTGGAAAGAAAAGG	0.512000													11	86					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44596233	44596233	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44596233C>T	ENST00000372299.3	+	3	1033	c.975C>T	c.(973-975)ttC>ttT	p.F325F	KLF17_ENST00000476802.1_3'UTR	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	325					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					GGTCTTTCTTCCGTTCTGATG	0.463000													38	85					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79165002	79165002	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:79165002G>A	ENST00000269392.4	-	22	3012	c.2765C>T	c.(2764-2766)gCc>gTc	p.A922V	AZI1_ENST00000575907.1_Missense_Mutation_p.A886V|AZI1_ENST00000450824.2_Missense_Mutation_p.A919V|AZI1_ENST00000374782.3_Missense_Mutation_p.A883V	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	922					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCGGCTCTCGGCAGCCTTCTC	0.647000													36	77					0	0	1	0	0
MRPS24	64951	broad.mit.edu	37	7	43906397	43906397	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:43906397G>A	ENST00000317534.5	-	4	466	c.405C>T	c.(403-405)ctC>ctT	p.L135L	RP5-1165K10.1_ENST00000603700.1_3'UTR	NM_032014.2	NP_114403.1	Q96EL2	RT24_HUMAN	mitochondrial ribosomal protein S24	135					translation	mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	5						TGTAGCCCACGAGGAAGTAGT	0.512000													35	67					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113298936	113298936	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:113298936G>A	ENST00000458497.1	+	3	282	c.3G>A	c.(1-3)atG>atA	p.M1I	ALPK1_ENST00000177648.9_Start_Codon_SNP_p.M1I|ALPK1_ENST00000504176.2_5'UTR	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TAATCATCATGAATAATCAAA	0.473000													49	194					0	0	1	0	0
BARHL1	56751	broad.mit.edu	37	9	135462841	135462841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135462841G>A	ENST00000263610.2	+	2	1205	c.592G>A	c.(592-594)Gag>Aag	p.E198K	BARHL1_ENST00000542090.1_Missense_Mutation_p.E198K	NM_020064.3	NP_064448.1	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	198						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(2)|lung(2)|skin(3)	8				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		GCGCAGCTTCGAGCGGCAGAA	0.662000													4	18					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30954233	30954233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:30954233C>T	ENST00000295055.8	-	21	2136	c.1960G>A	c.(1960-1962)Gga>Aga	p.G654R	CAPN13_ENST00000534090.2_Missense_Mutation_p.G654R	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	654	EF-hand 2.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AGGTAGAGTCCTTTTCCATCC	0.547000													4	13					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44590866	44590866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44590866C>T	ENST00000421176.3	+	5	1451	c.1235C>T	c.(1234-1236)tCa>tTa	p.S412L	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				TATATGAATTCACAGGGCCAT	0.433000													58	137					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744734	70744734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:70744734G>A	ENST00000260126.3	-	2	881	c.175C>T	c.(175-177)Ccg>Tcg	p.P59S	SLCO5A1_ENST00000528658.1_5'UTR|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.P59S|SLCO5A1_ENST00000530307.1_Missense_Mutation_p.P59S	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	59						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCAAAGGCCGGGTTGGCGTCT	0.652000											OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	49					0	0	1	0	0
TBPL2	387332	broad.mit.edu	37	14	55903341	55903341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:55903341G>A	ENST00000247219.5	-	2	616	c.546C>T	c.(544-546)tcC>tcT	p.S182S		NM_199047.2	NP_950248.1	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	182					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8						TGGGAGTTATGGATGCCAGAG	0.438000													42	73					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168112721	168112721	+	Missense_Mutation	SNP	C	C	T	rs143177032		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:168112721C>T	ENST00000519560.1	-	31	3945	c.3526G>A	c.(3526-3528)Gtc>Atc	p.V1176I	SLIT3_ENST00000332966.8_Missense_Mutation_p.V1183I|SLIT3_ENST00000404867.3_Missense_Mutation_p.V1176I	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1176	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGGGTCGGACCTTGGCGGAG	0.607000													26	65					0	0	1	0	0
CCR5	1234	broad.mit.edu	37	3	46415189	46415189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46415189C>T	ENST00000343801.4	+	3	1153	c.796C>T	c.(796-798)Ctg>Ttg	p.L266L	CCR5_ENST00000445772.1_Silent_p.L266L|CCR5_ENST00000292303.4_Silent_p.L266L|RP11-24F11.2_ENST00000451485.1_RNA	NM_000579.3	NP_000570.1	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5 (gene/pseudogene)	266					cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			central_nervous_system(1)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	ATTCTTTGGCCTGAATAATTG	0.468000													123	352					0	0	1	0	0
METTL3	56339	broad.mit.edu	37	14	21967278	21967278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21967278G>A	ENST00000298717.4	-	10	1673	c.1522C>T	c.(1522-1524)Cgt>Tgt	p.R508C	TOX4_ENST00000262709.3_3'UTR|TOX4_ENST00000405508.1_3'UTR	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	508					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		CTGGTGGAACGAACCTAGGAA	0.373000													24	39					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67801997	67801997	+	Silent	SNP	G	G	A	rs138108492	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:67801997G>A	ENST00000544246.1	-	2	1267	c.576C>T	c.(574-576)atC>atT	p.I192I	PCDH9_ENST00000377861.3_Silent_p.I192I|PCDH9_ENST00000328454.5_Silent_p.I192I|PCDH9_ENST00000377865.2_Silent_p.I192I|PCDH9_ENST00000456367.1_Silent_p.I192I	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	192	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GAGTTTCCACGATATCCAGTC	0.428000													53	166					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104512146	104512146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:104512146G>A	ENST00000372582.1	+	5	1375	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E207K	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	207	Ig-like C2-type 2.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGTTCAAGAAGAAGATGGAGG	0.333000													20	26					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768856	117768856	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:117768856C>T	ENST00000317775.6	-	2	704	c.19G>A	c.(19-21)Ggt>Agt	p.G7S	NOS1_ENST00000344089.3_Missense_Mutation_p.G7S|NOS1_ENST00000338101.4_Missense_Mutation_p.G7S	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	7	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGCTGAACACCGAACATGTGA	0.527000													10	105					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935870	30935870	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:30935870G>A	ENST00000355537.3	+	2	1548	c.1401G>A	c.(1399-1401)ggG>ggA	p.G467G		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AAGCGCTGGGGAAGCTGCTGT	0.642000													17	61					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33114106	33114106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33114106G>A	ENST00000307363.5	-	2	319	c.175C>T	c.(175-177)Cgt>Tgt	p.R59C	GLB1_ENST00000399402.3_Missense_Mutation_p.R29C|GLB1_ENST00000445488.2_Missense_Mutation_p.R107C|GLB1_ENST00000307377.8_Missense_Mutation_p.R59C	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	59			R -> C (in GM1G1; protein enzymatically inactive; severe mutation).|R -> H (in GM1G1; with cardiac involvement in some patients; protein enzymatically inactive; severe mutation).		carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				CGGGGCACACGGGAGTAGTGA	0.542000													19	69					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049049	9049049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9049049G>A	ENST00000397910.4	-	5	32785	c.32582C>T	c.(32581-32583)tCc>tTc	p.S10861F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10863	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGCTGAACTGGATTCTGCCCC	0.483000													37	97					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23811825	23811825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:23811825C>T	ENST00000354639.3	+	15	2288	c.1824C>T	c.(1822-1824)tcC>tcT	p.S608S	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000433467.2_Silent_p.S631S|STK31_ENST00000355870.3_Silent_p.S631S|STK31_ENST00000428484.1_Silent_p.S608S	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	631							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						ACTTGCTATCCATTAAGAAGA	0.313000													26	67					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75675519	75675519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:75675519G>A	ENST00000319410.5	-	3	370	c.249C>T	c.(247-249)gcC>gcT	p.A83A	KARS_ENST00000568378.1_Intron|KARS_ENST00000302445.3_Silent_p.A55A	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	55					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	TGTGGTTGGTGGCAGCAGCAG	0.537000													13	50					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87029421	87029421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:87029421C>T	ENST00000370563.3	+	4	568	c.526C>T	c.(526-528)Cgt>Tgt	p.R176C	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	176						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GCCTTTCTACCGTGCTAAGTC	0.398000													27	75					0	0	1	0	0
CHRNB3	1142	broad.mit.edu	37	8	42587083	42587083	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42587083G>A	ENST00000289957.2	+	5	761	c.633G>A	c.(631-633)ggG>ggA	p.G211G		NM_000749.3	NP_000740.1	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta 3 (neuronal)	211					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			endometrium(4)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GGATGAAGGGGAACAGAAGGG	0.468000													8	138					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39960881	39960881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39960881C>T	ENST00000599117.1	+	18	1864	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	SUPT5H_ENST00000598725.1_Silent_p.F499F|SUPT5H_ENST00000402194.2_Silent_p.F495F|SUPT5H_ENST00000359191.6_Silent_p.F495F|SUPT5H_ENST00000432763.2_Silent_p.F499F			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	499	KOW 3.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGGAGAATTTCGTTATCCTGT	0.552000													52	122					0	0	1	0	0
JDP2	122953	broad.mit.edu	37	14	75928233	75928233	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75928233G>A	ENST00000435893.2	+	3	579	c.306_splice	c.e3+1	p.R102_splice	JDP2_ENST00000437176.1_Splice_Site_p.R102_splice|JDP2_ENST00000419727.2_Splice_Site_p.R102_splice|JDP2_ENST00000267569.5_Splice_Site_p.R113_splice	NM_001135047.1|NM_130469.3	NP_001128519.1|NP_569736.1	Q8WYK2	JDP2_HUMAN	Jun dimerization protein 2	102	Leucine-zipper.					nucleus	sequence-specific DNA binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(234;0.0296)		TTCTGCAGCGGGTGAGCTGAC	0.582000													3	12					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25336839	25336839	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25336839C>T	ENST00000546682.1	+	0	942				SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						GGAATGTGATCTCTGTTGGGT	0.517000													11	27					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49244651	49244651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:49244651C>T	ENST00000406846.2	-	4	470	c.351G>A	c.(349-351)caG>caA	p.Q117Q	FSHR_ENST00000346173.3_Silent_p.Q117Q|FSHR_ENST00000304421.4_Silent_p.Q117Q	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	117					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGGGAAGGTTCTGGAAGGCCT	0.393000									Gonadal Dysgenesis, 46 XX				19	66					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68701305	68701305	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:68701305C>T	ENST00000255078.3	+	10	1572	c.1461C>T	c.(1459-1461)ccC>ccT	p.P487P	IGHMBP2_ENST00000541229.1_3'UTR	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	487					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CGGGTGTGCCCCTGCTCTTGG	0.647000													6	12					0	0	1	0	0
PROM1	8842	broad.mit.edu	37	4	16026826	16026826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:16026826C>T	ENST00000505450.1	-	5	1204	c.592G>A	c.(592-594)Gaa>Aaa	p.E198K	PROM1_ENST00000510224.1_Missense_Mutation_p.E207K|PROM1_ENST00000447510.2_Missense_Mutation_p.E207K|PROM1_ENST00000540805.1_Missense_Mutation_p.E207K|PROM1_ENST00000543373.1_Missense_Mutation_p.E198K|PROM1_ENST00000502943.1_5'UTR|PROM1_ENST00000539194.1_Missense_Mutation_p.E207K|PROM1_ENST00000508167.1_Missense_Mutation_p.E198K	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	207					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						TCTGGAGTTTCATTCAAGAGA	0.398000													52	113					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62066599	62066599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:62066599G>A	ENST00000404929.1	-	3	1551	c.1540C>T	c.(1540-1542)Ccc>Tcc	p.P514S	FAM161A_ENST00000405894.3_Missense_Mutation_p.P514S	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	514					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GTGGGCACGGGAGGGTTGCAG	0.478000													28	77					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717102	142717102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:142717102C>T	ENST00000381779.4	-	2	2048	c.1823G>A	c.(1822-1824)cGa>cAa	p.R608Q	SLITRK4_ENST00000356928.1_Missense_Mutation_p.R608Q|SLITRK4_ENST00000338017.4_Missense_Mutation_p.R608Q	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	608						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGGACTTCGAATGGGACC	0.418000													47	43					0	0	1	0	0
SPDL1	54908	broad.mit.edu	37	5	169021292	169021292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:169021292C>T	ENST00000265295.4	+	5	954	c.675C>T	c.(673-675)gcC>gcT	p.A225A	SPDL1_ENST00000510751.1_3'UTR	NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		ACTATAATGCCCTAGAGGTAC	0.348000													13	40					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626796	108626796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:108626796C>T	ENST00000264047.2	+	9	1498	c.1222C>T	c.(1222-1224)Ctc>Ttc	p.L408F	SLC5A7_ENST00000409059.1_Missense_Mutation_p.L408F|SLC5A7_ENST00000540517.1_Missense_Mutation_p.L303F	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	408					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	GCTCTGGTACCTCAGTTCTGA	0.473000													16	90					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29455288	29455288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29455288C>T	ENST00000389048.3	-	15	3420	c.2514G>A	c.(2512-2514)ctG>ctA	p.L838L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	838	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CTGCAATGATCAGGGGCACCG	0.572000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				15	35					0	0	1	0	0
TBC1D19	55296	broad.mit.edu	37	4	26719613	26719613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:26719613C>T	ENST00000264866.4	+	14	1291	c.1013C>T	c.(1012-1014)gCc>gTc	p.A338V	TBC1D19_ENST00000511789.1_Missense_Mutation_p.A273V	NM_018317.2	NP_060787.2	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	338	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	17		Breast(46;0.0503)				TTCAACAGTGCCTCGCCACCA	0.299000													33	97					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11632983	11632983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:11632983C>T	ENST00000423059.3	-	3	1420	c.1169G>A	c.(1168-1170)cGa>cAa	p.R390Q		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	390	TSP type-1 3.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCTGATGGTTCGTGTCCTTAC	0.512000										HNSCC(18;0.044)			22	42					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187629015	187629015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:187629015G>A	ENST00000441802.2	-	2	2176	c.1967C>T	c.(1966-1968)cCa>cTa	p.P656L		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	656	Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GATATATAATGGTGTGGCAAA	0.448000										HNSCC(5;0.00058)			30	74					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25003624	25003624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:25003624G>A	ENST00000537502.1	-	3	2194	c.663C>T	c.(661-663)atC>atT	p.I221I	ACSS1_ENST00000542618.1_Silent_p.I183I|ACSS1_ENST00000432802.2_Silent_p.I304I|ACSS1_ENST00000323482.4_Silent_p.I304I			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	304					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGGTATGGACGATGCCCTTGG	0.637000													9	26					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21990920	21990920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21990920G>A	ENST00000327430.3	-	2	3236	c.2942C>T	c.(2941-2943)tCt>tTt	p.S981F	SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron|SALL2_ENST00000450879.2_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	981							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		AGGGACTAGAGAAAGAGCAGC	0.562000													25	66					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103274171	103274171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:103274171C>T	ENST00000233969.2	+	2	580	c.438C>T	c.(436-438)ctC>ctT	p.L146L		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	146						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						TGTACCTCCTCCCACCCATCG	0.458000													63	237					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189850395	189850395	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189850395C>T	ENST00000304636.3	+	4	508	c.338C>T	c.(337-339)cCt>cTt	p.P113L	COL3A1_ENST00000317840.5_Missense_Mutation_p.P113L	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	113					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTTTAGGGCCCTCCTGGTATT	0.413000													7	13					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123629551	123629551	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123629551G>A	ENST00000369043.3	-	8	1031	c.945C>T	c.(943-945)ttC>ttT	p.F315F	ATE1_ENST00000369040.3_Silent_p.F219F|ATE1_ENST00000224652.6_Silent_p.F315F|ATE1_ENST00000543447.1_Silent_p.F200F|ATE1_ENST00000535655.1_Silent_p.F16F|ATE1_ENST00000540606.1_Silent_p.F308F|ATE1_ENST00000481784.1_5'UTR	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	315					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				GGAATCTTGTGAACTGCAGTC	0.338000													35	69					0	0	1	0	0
IL3	3562	broad.mit.edu	37	5	131398405	131398405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:131398405G>A	ENST00000296870.2	+	5	558	c.380G>A	c.(379-381)cGg>cAg	p.R127Q		NM_000588.3	NP_000579.2	P08700	IL3_HUMAN	interleukin 3 (colony-stimulating factor, multiple)	127					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)	10		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	AATGAATTCCGGAGGAAACTG	0.483000											OREG0016762	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	117					0	0	1	0	0
SLC7A10	56301	broad.mit.edu	37	19	33702229	33702229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:33702229G>A	ENST00000253188.3	-	7	1064	c.918C>T	c.(916-918)ttC>ttT	p.F306F		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	306					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					GCTTCTCCCCGAAGGTCTGGG	0.622000													9	47					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	98006765	98006765	+	Missense_Mutation	SNP	C	C	T	rs143109144	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98006765C>T	ENST00000224337.5	-	2	229	c.88G>A	c.(88-90)Ggt>Agt	p.G30S	BLNK_ENST00000371176.2_Missense_Mutation_p.G30S|BLNK_ENST00000413476.2_Missense_Mutation_p.G30S|BLNK_ENST00000427367.2_Missense_Mutation_p.G30S|BLNK_ENST00000495266.1_Missense_Mutation_p.G30S	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	30					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ATTATTCCACCTTCATTGTTT	0.254000													17	89					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140123538	140123538	+	Silent	SNP	C	C	T	rs142111816	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:140123538C>T	ENST00000458420.3	+	4	757	c.567C>T	c.(565-567)tcC>tcT	p.S189S		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	189	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						AGGACTGCTCCCCACAGTACA	0.537000										HNSCC(16;0.037)			19	89					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69683824	69683824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:69683824C>T	ENST00000265403.7	+	2	823	c.796C>T	c.(796-798)Cct>Tct	p.P266S	UGT2B10_ENST00000458688.2_Missense_Mutation_p.P182S	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	266					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TTTTAAATTTCCTCATCCATT	0.383000													76	205					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3905604	3905604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3905604G>A	ENST00000450849.2	+	4	776	c.309G>A	c.(307-309)gaG>gaA	p.E103E	ATCAY_ENST00000600960.1_Silent_p.E103E|ATCAY_ENST00000301260.6_Silent_p.E103E|ATCAY_ENST00000398448.3_Silent_p.E109E	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	103					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCCCGATGAGACCGACTCGC	0.582000													28	70					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77973147	77973147	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:77973147C>T	ENST00000354212.4	-	9	1609	c.1356G>A	c.(1354-1356)gtG>gtA	p.V452V	MAGI2_ENST00000535697.1_Silent_p.V289V|MAGI2_ENST00000522391.1_Silent_p.V452V|MAGI2_ENST00000419488.1_Silent_p.V452V|MAGI2_ENST00000536571.1_Silent_p.V284V	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	452	PDZ 2.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TCACACTTTTCACCTGCAGAA	0.438000													25	61					0	0	1	0	0
HACE1	57531	broad.mit.edu	37	6	105219820	105219820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:105219820G>A	ENST00000262903.4	-	18	2270	c.1994C>T	c.(1993-1995)tCc>tTc	p.S665F	HACE1_ENST00000369125.2_Intron|HACE1_ENST00000517995.1_5'UTR	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	665	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		CTTGTAGAAGGATCGTGTGAA	0.363000													28	48					0	0	1	0	0
ZNF441	126068	broad.mit.edu	37	19	11891923	11891923	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11891923C>T	ENST00000357901.4	+	4	1386	c.1284C>T	c.(1282-1284)ttC>ttT	p.F428F	ZNF441_ENST00000454339.2_Silent_p.F361F	NM_152355.2	NP_689568.2	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GAAAAGCCTTCATTTGTTGCA	0.368000													22	49					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65252522	65252522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65252522C>T	ENST00000389722.3	-	16	3762	c.3709G>A	c.(3709-3711)Gag>Aag	p.E1237K	SPTB_ENST00000556626.1_Missense_Mutation_p.E1237K|SPTB_ENST00000542895.1_Missense_Mutation_p.E1237K|SPTB_ENST00000389721.5_Missense_Mutation_p.E1237K|SPTB_ENST00000389720.3_Missense_Mutation_p.E1237K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1237					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AGGTTTCCCTCAGCTACCAGC	0.562000													16	286					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136564711	136564711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136564711G>A	ENST00000264162.2	-	9	4170	c.4160C>T	c.(4159-4161)tCt>tTt	p.S1387F		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1387	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity	p.S1387F(1)		breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATATGCAGCAGAAGCTGCACT	0.567000													16	81					0	0	1	0	0
OR7D4	125958	broad.mit.edu	37	19	9324768	9324768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9324768G>A	ENST00000308682.2	-	1	774	c.746C>T	c.(745-747)tCc>tTc	p.S249F		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						ATAGAACAAGGAGACCACACA	0.517000													24	52					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38938645	38938645	+	Silent	SNP	G	G	A	rs145915658		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38938645G>A	ENST00000302328.3	-	14	2292	c.2094C>T	c.(2092-2094)gtC>gtT	p.V698V	SCN11A_ENST00000456224.3_Silent_p.V698V|SCN11A_ENST00000444237.2_Silent_p.V698V|SCN11A_ENST00000450244.1_Silent_p.V698V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	698					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CAAGGGCTCCGACAGAGTTGC	0.433000													16	54					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141163939	141163939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141163939C>T	ENST00000514251.1	+	4	2988	c.2709C>T	c.(2707-2709)ttC>ttT	p.F903F	ZBTB38_ENST00000441582.2_Silent_p.F903F|ZBTB38_ENST00000321464.5_Silent_p.F904F			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	903					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.F903F(1)		breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						GTGAAGTGTTCGATGACGCAA	0.507000													24	53					0	0	1	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79629664	79629664	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:79629664C>A	ENST00000263849.4	+	9	1016	c.914C>A	c.(913-915)aCt>aAt	p.T305N		NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	305																	GAGTGTGGGACTAAATACCCT	0.388000													58	131					2.60599e-31	2.6237e-31	1	1	0
AIFM3	150209	broad.mit.edu	37	22	21333929	21333929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:21333929C>T	ENST00000399167.2	+	18	1830	c.1590C>T	c.(1588-1590)ggC>ggT	p.G530G	LZTR1_ENST00000479606.1_3'UTR|AIFM3_ENST00000405089.1_Silent_p.G536G|AIFM3_ENST00000399163.2_Silent_p.G530G|AIFM3_ENST00000465606.1_3'UTR|AIFM3_ENST00000440238.2_Silent_p.G530G|AIFM3_ENST00000335375.5_Silent_p.G518G|AIFM3_ENST00000333607.6_Silent_p.G530G	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			ACGGAGAAGGCTTCGACGACG	0.642000													55	162					0	0	1	0	0
HLA-G	3135	broad.mit.edu	37	6	29797602	29797602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29797602C>T	ENST00000428701.1	+	6	1083	c.905C>T	c.(904-906)tCc>tTc	p.S302F	HLA-G_ENST00000376828.2_Missense_Mutation_p.S307F|HLA-G_ENST00000360323.6_Missense_Mutation_p.S302F|HLA-G_ENST00000376818.3_Missense_Mutation_p.S210F|HLA-G_ENST00000376815.3_Missense_Mutation_p.S118F	NM_002127.5	NP_002118.1	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	302	Connecting peptide.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(5)|skin(1)	21						GAGCAGTCTTCCCTGCCCACC	0.582000													11	101					0	0	1	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806670	6806670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6806670C>T	ENST00000307401.4	+	1	423	c.402C>T	c.(400-402)acC>acT	p.T134T		NM_001004489.2	NP_001004489.1	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CATACATGACCCTCATGAGCT	0.527000													19	53					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488413	1488413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:1488413G>A	ENST00000345913.4	+	9	1475	c.1384G>A	c.(1384-1386)Gcc>Acc	p.A462T	TPO_ENST00000497517.2_3'UTR|TPO_ENST00000349624.3_Missense_Mutation_p.A289T|TPO_ENST00000382198.1_Missense_Mutation_p.A289T|TPO_ENST00000337415.3_Missense_Mutation_p.A462T|TPO_ENST00000382201.3_Missense_Mutation_p.A462T|TPO_ENST00000329066.4_Missense_Mutation_p.A462T|TPO_ENST00000346956.3_Missense_Mutation_p.A462T	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	462					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGACCCGAGGCCTTCCAGCA	0.592000													17	26					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115573981	115573981	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:115573981C>T	ENST00000371900.4	+	4	561	c.473C>T	c.(472-474)tCg>tTg	p.S158L		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	158					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	AATTGTTCTTCGTGGTCAGAT	0.303000													64	34					0	0	1	0	0
ARL10	285598	broad.mit.edu	37	5	175793522	175793522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:175793522C>T	ENST00000310389.5	+	2	419	c.323C>T	c.(322-324)cCc>cTc	p.P108L		NM_173664.4	NP_775935.1	Q8N8L6	ARL10_HUMAN	ADP-ribosylation factor-like 10	108							GTP binding			endometrium(2)|lung(1)|ovary(1)	4	all_cancers(89;0.0064)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.0965)		GGCCACATCCCCACCTGGGGC	0.637000													10	52					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47680242	47680242	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47680242G>A	ENST00000283303.2	+	5	708	c.450G>A	c.(448-450)gtG>gtA	p.V150V	GPR115_ENST00000371220.1_Silent_p.V207V|GPR115_ENST00000327753.3_Silent_p.V150V	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	150					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CTGACATGGTGAAATCATCAG	0.373000													35	106					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53165751	53165751	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53165751C>T	ENST00000332411.2	-	6	1220	c.1167G>A	c.(1165-1167)agG>agA	p.R389R		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	389	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CATCCCCATGCCTGCCAGCTG	0.507000													39	73					0	0	1	0	0
CLUL1	27098	broad.mit.edu	37	18	641370	641370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:641370G>A	ENST00000581619.1	+	7	1960	c.1113G>A	c.(1111-1113)gcG>gcA	p.A371A	C18orf56_ENST00000585033.1_3'UTR|CLUL1_ENST00000540035.1_Silent_p.A398A|CLUL1_ENST00000338387.7_Silent_p.A346A|CLUL1_ENST00000400606.2_Silent_p.A346A|CLUL1_ENST00000579494.1_Silent_p.A346A			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	346					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						TAGACGAGGCGATCAGGTTGG	0.493000													21	81					0	0	1	0	0
DDX25	29118	broad.mit.edu	37	11	125780323	125780323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:125780323G>A	ENST00000263576.6	+	7	727	c.572G>A	c.(571-573)gGa>gAa	p.G191E	RP11-680F20.9_ENST00000533033.2_RNA|DDX25_ENST00000525943.1_3'UTR	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	191	Helicase ATP-binding.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		GAGCAGATGGGAAAATTCTGT	0.483000													11	102					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10081488	10081488	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10081488C>T	ENST00000287647.3	+	9	747	c.654C>T	c.(652-654)atC>atT	p.I218I	FANCD2_ENST00000438741.1_3'UTR|FANCD2_ENST00000431693.1_Silent_p.I218I|FANCD2_ENST00000383807.1_Silent_p.I218I|FANCD2_ENST00000419585.1_Silent_p.I218I|FANCD2_ENST00000383806.1_Silent_p.I218I	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	218	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TACCTGAGATCCTAGGGGATT	0.512000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	81					0	0	1	0	0
FAM153C	653316	broad.mit.edu	37	5	177473889	177473889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:177473889C>T	ENST00000398106.2	+	9	743	c.290C>T	c.(289-291)tCc>tTc	p.S97F	FAM153C_ENST00000507848.1_Missense_Mutation_p.S97F|FAM153C_ENST00000511189.1_Missense_Mutation_p.S126F					family with sequence similarity 153, member C											kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAAGTCCTTCCTCTGCACCT	0.527000													26	82					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167659303	167659303	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:167659303G>A	ENST00000367854.3	+	4	547	c.216G>A	c.(214-216)gcG>gcA	p.A72A	RCSD1_ENST00000537350.1_Silent_p.A42A	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	72										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CACCCAATGCGAGCCACCCTC	0.453000													36	109					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148037913	148037913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:148037913C>T	ENST00000370460.2	+	11	2817	c.2338C>T	c.(2338-2340)Cct>Tct	p.P780S	AFF2_ENST00000286437.5_Missense_Mutation_p.P421S|AFF2_ENST00000370457.5_Missense_Mutation_p.P747S|AFF2_ENST00000342251.3_Missense_Mutation_p.P747S	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	780					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					AACATTTTCACCTATTCCTGT	0.458000													26	40					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160862250	160862250	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160862250G>A	ENST00000283243.7	-	11	1953	c.1747C>T	c.(1747-1749)Caa>Taa	p.Q583*	PLA2R1_ENST00000392771.1_Nonsense_Mutation_p.Q583*	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	583	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GTATCATTTTGGTCCTGAAGA	0.448000													9	130					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	161966466	161966466	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161966466C>T	ENST00000366892.1	-	10	1182	c.1087G>A	c.(1087-1089)Gga>Aga	p.G363R	PARK2_ENST00000366894.1_Intron|PARK2_ENST00000366898.1_Intron|PARK2_ENST00000338468.3_Intron|PARK2_ENST00000366897.1_Intron|PARK2_ENST00000366896.1_Intron			O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	0					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		cttcgttgtccatactgtgag	0.363000													9	10					0	0	1	0	0
KLRC4-KLRK1	100528032	broad.mit.edu	37	12	10560269	10560269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:10560269G>A	ENST00000539300.1	-	4	433	c.434C>T	c.(433-435)tCt>tTt	p.S145F	KLRC4_ENST00000309384.1_Silent_p.L154L																							AAGCAGATCAGAGTTCTTCGA	0.348000													30	267					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103377716	103377716	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:103377716C>T	ENST00000358392.2	-	54	4438	c.4122_splice	c.e54+1	p.R1374_splice	COL11A1_ENST00000512756.1_Splice_Site_p.R1246_splice|COL11A1_ENST00000353414.4_Splice_Site_p.R1323_splice|COL11A1_ENST00000370096.3_Splice_Site_p.R1362_splice	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1362	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GAAACTTACTCGTTTTCCAGG	0.363000													8	23					0	0	1	0	0
RFC1	5981	broad.mit.edu	37	4	39304389	39304389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:39304389G>A	ENST00000381897.1	-	17	2444	c.2311C>T	c.(2311-2313)Cgt>Tgt	p.R771C	RFC1_ENST00000349703.2_Missense_Mutation_p.R770C	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	771					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						CTTTGAAAACGAAGATCAAAA	0.318000													16	59					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89651233	89651233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89651233G>A	ENST00000268720.5	+	7	914	c.784G>A	c.(784-786)Gac>Aac	p.D262N	CPNE7_ENST00000319518.8_Missense_Mutation_p.D187N	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	262	C2 2.				lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GGTCAACGACGACCAGGGCTT	0.657000													6	28					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18112930	18112930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:18112930G>A	ENST00000403915.1	+	3	1106	c.655G>A	c.(655-657)Gat>Aat	p.D219N	KCNS3_ENST00000304101.4_Missense_Mutation_p.D219N|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	219					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGAAGTGGATGATCCGGTGCT	0.572000													19	78					0	0	1	0	0
ENKUR	219670	broad.mit.edu	37	10	25284783	25284783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25284783C>T	ENST00000331161.4	-	3	458	c.239G>A	c.(238-240)cGg>cAg	p.R80Q	ENKUR_ENST00000376363.1_Missense_Mutation_p.R80Q	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	80						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						GGGCACGTTCCGATCAAAGTT	0.333000													13	133					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242815135	242815135	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242815135C>T	ENST00000343216.3	+	2	1456	c.1428C>T	c.(1426-1428)ttC>ttT	p.F476F		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	476						integral to membrane											CCATCCCCTTCGCAGTCTTCG	0.627000													19	99					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119927487	119927487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119927487C>T	ENST00000361035.4	+	5	694	c.411C>T	c.(409-411)ctC>ctT	p.L137L	HAO2_ENST00000325945.3_Silent_p.L124L	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	124	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		CCGAAGGCCTCCGATGGTTCC	0.488000													15	126					0	0	1	0	0
EFCAB1	79645	broad.mit.edu	37	8	49643999	49643999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:49643999C>T	ENST00000262103.3	-	2	202	c.122G>A	c.(121-123)aGg>aAg	p.R41K	EFCAB1_ENST00000523092.1_Intron|EFCAB1_ENST00000521002.1_Intron|EFCAB1_ENST00000433756.1_Intron	NM_024593.3	NP_078869.1	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1	41							calcium ion binding			endometrium(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(2)	14		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				CAGACCTTGCCTCTCTACTCC	0.358000													13	48					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486458	125486458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125486458C>T	ENST00000259466.1	+	1	190	c.190C>T	c.(190-192)Ctc>Ttc	p.L64F		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						GTACTTTTTTCTCAGCAACTT	0.453000													27	74					0	0	1	0	0
ATP6V1F	9296	broad.mit.edu	37	7	128503058	128503058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:128503058C>T	ENST00000492758.1	+	1	101	c.100C>T	c.(100-102)Ccc>Tcc	p.P34S	ATP6V1F_ENST00000249289.4_Missense_Mutation_p.P34S	NM_001198909.1	NP_001185838.1	Q16864	VATF_HUMAN	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F	34					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|membrane fraction|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATPase activity, uncoupled|hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding|proton-transporting ATPase activity, rotational mechanism			lung(1)|ovary(1)|prostate(1)	3						GAACCGCCATCCCAATTTCCT	0.582000											OREG0018299	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	78					0	0	1	0	0
NUP210P1	255330	broad.mit.edu	37	3	126386152	126386152	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:126386152C>T	ENST00000357061.3	+	0	604					NR_034158.1																						GGTCTGTCACCAAGCGGGACA	0.602000													13	28					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827096	96827096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:96827096C>T	ENST00000371270.3	-	3	444	c.350G>A	c.(349-351)gGa>gAa	p.G117E	CYP2C8_ENST00000535898.1_Missense_Mutation_p.G15E|CYP2C8_ENST00000539050.1_Missense_Mutation_p.G31E	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	117					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CCATCTCTTTCCATTGCTGGA	0.488000													27	77					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38967280	38967280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:38967280G>A	ENST00000357387.3	-	14	1231	c.1201C>T	c.(1201-1203)Cgt>Tgt	p.R401C	RICTOR_ENST00000296782.5_Missense_Mutation_p.R401C	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	401					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					AGTCCATTACGAATAAATGCA	0.343000													85	202					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4433534	4433534	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4433534C>T	ENST00000301280.5	+	13	2772	c.2671C>T	c.(2671-2673)Cag>Tag	p.Q891*		NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	891	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACGACGGCCAGGTGAGGTG	0.552000								Chromatin Structure					14	33					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518403	113518403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113518403G>A	ENST00000284601.3	-	4	2812	c.2744C>T	c.(2743-2745)cCt>cTt	p.P915L		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	915					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTTGGAAAAAGGAGAGCTATT	0.403000													34	101					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8193951	8193951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:8193951G>A	ENST00000600128.1	-	18	2671	c.2257C>T	c.(2257-2259)Ccc>Tcc	p.P753S	FBN3_ENST00000601739.1_Missense_Mutation_p.P753S|FBN3_ENST00000270509.2_Missense_Mutation_p.P753S			Q75N90	FBN3_HUMAN	fibrillin 3	753	EGF-like 9; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGGAAGCCGGGGGGGCAGGAG	0.602000													25	67					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785468	134785468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:134785468G>A	ENST00000537858.1	-	2	362	c.162C>T	c.(160-162)tcC>tcT	p.S54S		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	54	FHA.									breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTGACGGCGGGAGAGGCGAG	0.657000													6	64					0	0	1	0	0
EMCN	51705	broad.mit.edu	37	4	101396232	101396232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:101396232C>T	ENST00000296420.4	-	3	400	c.222G>A	c.(220-222)ctG>ctA	p.L74L	EMCN_ENST00000305864.3_Silent_p.L74L|EMCN_ENST00000502327.1_5'UTR|EMCN_ENST00000511970.1_Silent_p.L74L	NM_001159694.1|NM_016242.3	NP_001153166.1|NP_057326.2	Q9ULC0	MUCEN_HUMAN	endomucin	74	Thr-rich.					extracellular region|integral to membrane|plasma membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		CTGTTGACATCAGAGACATTT	0.229000													7	58					0	0	1	0	0
OR52I1	390037	broad.mit.edu	37	11	4615509	4615509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:4615509G>A	ENST00000450052.2	+	2	313	c.313G>A	c.(313-315)Gtg>Atg	p.V105M	OR52I1_ENST00000530443.2_Missense_Mutation_p.V81M			Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I, member 1	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	15		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCCTCCTCCGTGGTACCCAA	0.502000													30	176					0	0	1	0	0
SUOX	6821	broad.mit.edu	37	12	56396389	56396389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:56396389C>T	ENST00000394109.3	+	2	837	c.113C>T	c.(112-114)cCc>cTc	p.P38L	SUOX_ENST00000551841.2_Missense_Mutation_p.P38L|SUOX_ENST00000356124.4_Missense_Mutation_p.P38L|SUOX_ENST00000266971.3_Missense_Mutation_p.P38L|SUOX_ENST00000550478.1_3'UTR|SUOX_ENST00000394115.2_Missense_Mutation_p.P38L|SUOX_ENST00000548274.1_Missense_Mutation_p.P38L			P51687	SUOX_HUMAN	sulfite oxidase	38						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)	15			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			TCATTTCAGCCCCAGCGCCCC	0.537000													51	128					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231335984	231335984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:231335984G>A	ENST00000444294.3	+	4	2212	c.1354G>A	c.(1354-1356)Gac>Aac	p.D452N	TRIM67_ENST00000366653.5_Missense_Mutation_p.D452N|TRIM67_ENST00000449018.3_Missense_Mutation_p.D390N|TRIM67_ENST00000366652.2_Missense_Mutation_p.D452N	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	452	COS.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CAAGGAGAACGACCCCTCCGG	0.542000													33	79					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58207358	58207358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:58207358G>A	ENST00000302572.2	-	1	288	c.267C>T	c.(265-267)ttC>ttT	p.F89F		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F89L(1)		large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TATATAATATGAATTTGTCTC	0.453000													24	60					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57185366	57185366	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57185366C>T	ENST00000343433.6	-	20	2246		c.e20-1			NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						ACTTTGATGCCTGTGAAAAAA	0.343000													8	37					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932157	83932157	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83932157C>G	ENST00000345382.2	-	4	1931	c.1846G>C	c.(1846-1848)Gag>Cag	p.E616Q	BNC1_ENST00000569704.1_Missense_Mutation_p.E609Q|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	616					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						CCACTGGACTCAATTACTGAT	0.542000													7	122					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24573359	24573359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24573359C>T	ENST00000319715.4	+	10	1598	c.1166C>T	c.(1165-1167)tCt>tTt	p.S389F	RBBP6_ENST00000348022.2_Missense_Mutation_p.S389F|RBBP6_ENST00000381039.3_Missense_Mutation_p.S389F	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	389					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TCATTAACTTCTAATCAGTCT	0.438000													8	144					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99690308	99690308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:99690308C>T	ENST00000524871.1	+	4	379	c.89C>T	c.(88-90)tCa>tTa	p.S30L	CNTN5_ENST00000527185.1_Missense_Mutation_p.S30L|CNTN5_ENST00000528682.1_Missense_Mutation_p.S30L|CNTN5_ENST00000279463.3_Missense_Mutation_p.S30L|CNTN5_ENST00000418526.2_Intron	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	30					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTCTCCACTTCATATGCTGCT	0.338000													16	145					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114057955	114057955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:114057955G>A	ENST00000462705.1	-	12	2725	c.1904C>T	c.(1903-1905)gCc>gTc	p.A635V	ZBTB20_ENST00000464560.1_Missense_Mutation_p.A635V|ZBTB20_ENST00000481632.1_Missense_Mutation_p.A635V|ZBTB20_ENST00000471418.1_Missense_Mutation_p.A635V|ZBTB20_ENST00000474710.1_Missense_Mutation_p.A708V|ZBTB20_ENST00000393785.2_Missense_Mutation_p.A635V|ZBTB20_ENST00000357258.3_Missense_Mutation_p.A635V	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	708					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CTCCGTGCAGGCCACCACGCC	0.647000													28	55					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144995679	144995679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144995679G>A	ENST00000322810.4	-	32	8890	c.8721C>T	c.(8719-8721)gcC>gcT	p.A2907A	PLEC_ENST00000356346.3_Silent_p.A2756A|PLEC_ENST00000357649.2_Silent_p.A2774A|PLEC_ENST00000436759.2_Silent_p.A2797A|PLEC_ENST00000527096.1_Silent_p.A2793A|PLEC_ENST00000398774.2_Silent_p.A2738A|PLEC_ENST00000345136.3_Silent_p.A2770A|PLEC_ENST00000354589.3_Silent_p.A2770A|PLEC_ENST00000354958.2_Silent_p.A2748A	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2907	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGGCGCGCTCGGCCGACAGCA	0.657000													20	64					0	0	1	0	0
GALP	85569	broad.mit.edu	37	19	56691959	56691959	+	Missense_Mutation	SNP	G	G	A	rs149853638		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56691959G>A	ENST00000357330.2	+	3	174	c.92G>A	c.(91-93)cGa>cAa	p.R31Q	GALP_ENST00000440823.1_Intron|GALP_ENST00000590002.1_Intron	NM_033106.3	NP_149097.1	Q9UBC7	GALP_HUMAN	galanin-like peptide	31					neuropeptide signaling pathway	extracellular region	hormone activity			lung(4)	4		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		ATCCAGGGACGAGGAGGCTGG	0.607000													10	54					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624387	123624387	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123624387G>A	ENST00000327930.2	-	1	866	c.840C>T	c.(838-840)acC>acT	p.T280T		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TCAGAAGGGGGGTGAGGATAG	0.443000													37	99					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371224	240371224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240371224G>A	ENST00000319653.9	+	5	3342	c.3112G>A	c.(3112-3114)Gga>Aga	p.G1038R		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1038	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCACTTCCCGGAGCGGGCAT	0.731000													12	47					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122836061	122836061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:122836061C>T	ENST00000264811.5	-	3	1414	c.996G>A	c.(994-996)acG>acA	p.T332T	TRPC3_ENST00000379645.3_Silent_p.T405T|TRPC3_ENST00000513531.1_Intron	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	320					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CATACCAGATCGTCAAGAGCT	0.512000													16	38					0	0	1	0	0
VIP	7432	broad.mit.edu	37	6	153078241	153078241	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:153078241G>A	ENST00000367244.3	+	6	650	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K	VIP_ENST00000367243.3_Missense_Mutation_p.E159K	NM_003381.3	NP_003372.1	P01282	VIP_HUMAN	vasoactive intestinal peptide	160					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity			haematopoietic_and_lymphoid_tissue(1)|lung(4)|skin(1)	6		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		CAGTGAGGGAGAATCTCCCGA	0.403000													12	18					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140249931	140249931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140249931G>A	ENST00000398640.2	+	1	1243	c.1243G>A	c.(1243-1245)Gag>Aag	p.E415K	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGACCGCGAGAACGTGTG	0.627000													67	180					0	0	1	0	0
PEX5	5830	broad.mit.edu	37	12	7351705	7351705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7351705C>T	ENST00000266563.5	+	6	730	c.547C>T	c.(547-549)Cgc>Tgc	p.R183C	PEX5_ENST00000434354.2_Missense_Mutation_p.R198C|PEX5_ENST00000545220.1_Intron|PEX5_ENST00000420616.2_Missense_Mutation_p.R183C|PEX5_ENST00000412720.2_Missense_Mutation_p.R204C|PEX5_ENST00000266564.3_Missense_Mutation_p.R183C|PEX5_ENST00000455147.2_Missense_Mutation_p.R183C	NM_001131024.1	NP_001124496.1	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5	183					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)	21						AGCCACCGATCGCTGGTGAGT	0.532000													5	10					0	0	1	0	0
NUP54	53371	broad.mit.edu	37	4	77055431	77055431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:77055431G>A	ENST00000264883.3	-	5	747	c.607C>T	c.(607-609)Cga>Tga	p.R203*	NUP54_ENST00000514987.1_Nonsense_Mutation_p.R155*|NUP54_ENST00000342467.6_Nonsense_Mutation_p.R23*|NUP54_ENST00000458189.2_Nonsense_Mutation_p.R23*|NUP54_ENST00000515460.1_5'UTR	NM_017426.2	NP_059122.2	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	203	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(3)|skin(1)|stomach(1)	19						TGTTGGCTTCGAATCTCTGTT	0.388000													7	60					0	0	1	0	0
RERGL	79785	broad.mit.edu	37	12	18234369	18234369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:18234369C>T	ENST00000229002.2	-	6	580	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	RERGL_ENST00000536890.1_3'UTR|RERGL_ENST00000538724.1_Missense_Mutation_p.R124Q|RERGL_ENST00000541632.1_5'UTR	NM_024730.2	NP_079006.1	Q9H628	RERGL_HUMAN	RERG/RAS-like	125	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity			endometrium(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	17						ACAAAGATCTCGTTTGTTGCC	0.408000													35	83					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87179319	87179319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87179319C>T	ENST00000265724.3	-	14	1819	c.1402G>A	c.(1402-1404)Gaa>Aaa	p.E468K	ABCB1_ENST00000543898.1_Missense_Mutation_p.E404K	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	468	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CCAATGATTTCCCGTAGAAAC	0.408000													36	110					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44053363	44053363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:44053363G>A	ENST00000306006.6	-	2	817	c.165C>T	c.(163-165)ttC>ttT	p.F55F	ZNF239_ENST00000491188.1_5'UTR|ZNF239_ENST00000374446.2_Silent_p.F55F|ZNF239_ENST00000535642.1_Silent_p.F55F|ZNF239_ENST00000426961.1_Silent_p.F55F	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	55					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding	p.F55F(1)		endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						CAATGTTTTCGAAACAACCAC	0.413000													46	106					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57415743	57415743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57415743C>T	ENST00000313949.7	+	1	971	c.582C>T	c.(580-582)ctC>ctT	p.L194L	GNAS-AS1_ENST00000598163.1_RNA|GNAS_ENST00000371098.2_Silent_p.L194L|GNAS_ENST00000371075.3_Silent_p.L194L|GNAS-AS1_ENST00000443966.1_RNA|GNAS-AS1_ENST00000424094.2_RNA			P63092	GNAS2_HUMAN	GNAS complex locus	319					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GGGAGGAGCTCAAGCCCGAGG	0.667000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			5	17					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178562966	178562966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178562966C>T	ENST00000251582.7	-	13	2130	c.2029G>A	c.(2029-2031)Ggg>Agg	p.G677R		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	677	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CAGCGCGTCCCGTCATGCACC	0.642000													34	64					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94032040	94032040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:94032040G>A	ENST00000282020.4	+	4	929	c.671G>A	c.(670-672)cGa>cAa	p.R224Q	GRID2_ENST00000510992.1_Missense_Mutation_p.R129Q|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	224					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AATCGCTATCGAGACACTCTT	0.408000													35	93					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71016297	71016297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:71016297C>T	ENST00000334414.6	-	3	625	c.581G>A	c.(580-582)aGa>aAa	p.R194K	PTPRB_ENST00000550358.1_Missense_Mutation_p.R194K|PTPRB_ENST00000551525.1_Missense_Mutation_p.R193K|PTPRB_ENST00000538174.2_5'UTR	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 2.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGCAGCATTTCTGATGAAGGC	0.468000													7	24					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869693	36869693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36869693G>A	ENST00000279024.4	-	3	1111	c.840C>T	c.(838-840)ggC>ggT	p.G280G		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	280										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CTTGGGAAAAGCCTAGGAGAG	0.567000													44	97					0	0	1	0	0
ADCK4	79934	broad.mit.edu	37	19	41211272	41211272	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41211272G>A	ENST00000324464.3	-	6	749	c.448C>T	c.(448-450)Cga>Tga	p.R150*	ADCK4_ENST00000450541.1_Intron|ADCK4_ENST00000243583.6_Intron	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	150						integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GCGGCCCCTCGAACTGTACAT	0.607000													27	52					0	0	1	0	0
SPOCK1	6695	broad.mit.edu	37	5	136602719	136602719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:136602719G>A	ENST00000394945.1	-	3	381	c.212C>T	c.(211-213)cCc>cTc	p.P71L	SPOCK1_ENST00000282223.7_Missense_Mutation_p.P71L	NM_004598.3	NP_004589.1	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	71					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGGCTTGTTGGGATTCCAGTT	0.363000													45	98					0	0	1	0	0
FBXW4	6468	broad.mit.edu	37	10	103433321	103433321	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103433321G>A	ENST00000331272.7	-	3	1084	c.466C>T	c.(466-468)Ctg>Ttg	p.L156L		NM_022039.3	NP_071322.1	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	156					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				breast(3)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	15		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		AAGACTCCCAGAGGCCGACGA	0.512000													42	166					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140752118	140752118	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140752118C>T	ENST00000576222.1	+	1	2288	c.2157C>T	c.(2155-2157)tcC>tcT	p.S719S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGCTCCTCCAGACCCGCCA	0.557000													17	56					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160035504	160035504	+	Silent	SNP	C	C	T	rs148016866	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160035504C>T	ENST00000263635.6	+	14	2577	c.2340C>T	c.(2338-2340)ggC>ggT	p.G780G	TANC1_ENST00000454300.1_Silent_p.G674G	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	780						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						TTAATGCTGGCCACATCCAGG	0.572000													46	205					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117114252	117114252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:117114252C>T	ENST00000310357.3	-	6	1855	c.1834G>A	c.(1834-1836)Ggc>Agc	p.G612S	GPRC6A_ENST00000368549.3_Missense_Mutation_p.G541S|GPRC6A_ENST00000530250.1_Missense_Mutation_p.G437S	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	612					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AATATTATGCCAACAACCAGA	0.418000													34	63					0	0	1	0	0
TRGV5	6978	broad.mit.edu	37	7	38389232	38389232	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:38389232C>T	ENST00000390344.2	-	0	275																											TGACTGACTTCGTTCCCCCTT	0.453000													24	61					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98369528	98369528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:98369528G>A	ENST00000339364.5	-	14	2230	c.2111C>T	c.(2110-2112)cCc>cTc	p.P704L	PIK3AP1_ENST00000371109.3_Missense_Mutation_p.P303L|PIK3AP1_ENST00000371110.2_Missense_Mutation_p.P526L	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	704						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CGTCCTAGGGGGAATGACACT	0.577000													111	255					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155931555	155931555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:155931555G>A	ENST00000368316.1	-	15	1751	c.1281C>T	c.(1279-1281)acC>acT	p.T427T	ARHGEF2_ENST00000368315.3_Silent_p.T456T|ARHGEF2_ENST00000361247.4_Silent_p.T455T|ARHGEF2_ENST00000313667.4_Silent_p.T454T|ARHGEF2_ENST00000313695.7_Silent_p.T427T			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	455	DH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CAGGCACTGGGGTTTGGGCCC	0.602000													21	60					0	0	1	0	0
DHX40	79665	broad.mit.edu	37	17	57679906	57679906	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:57679906C>T	ENST00000451169.2	+	18	2045	c.1686C>T	c.(1684-1686)acC>acT	p.T562T	DHX40_ENST00000425628.3_Silent_p.T533T|DHX40_ENST00000251241.4_Silent_p.T610T			Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	610							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CAAAAGAGACCTTTGAAGGCC	0.338000													21	74					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88768356	88768356	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:88768356G>A	ENST00000444431.1	+	0	2956				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GACACCATCGGGAGCGGCAGA	0.512000													139	358					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40585181	40585181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40585181C>T	ENST00000260402.3	-	21	2521	c.2272G>A	c.(2272-2274)Gaa>Aaa	p.E758K	PLCB2_ENST00000456256.2_Missense_Mutation_p.E758K|PLCB2_ENST00000557821.1_Missense_Mutation_p.E754K	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	758	C2.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TTGTTGCCTTCCTCCATCACA	0.562000													24	80					0	0	1	0	0
ASIC4	55515	broad.mit.edu	37	2	220396532	220396532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220396532C>T	ENST00000358078.4	+	2	1030	c.1016C>T	c.(1015-1017)tCg>tTg	p.S339L	ASIC4_ENST00000473709.1_3'UTR|ASIC4_ENST00000347842.3_Missense_Mutation_p.S339L			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	339						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										CCGCGGAGCTCGCTGCCCAGC	0.622000													24	125					0	0	1	0	0
C10orf76	79591	broad.mit.edu	37	10	103755098	103755098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103755098G>A	ENST00000370033.4	-	16	1284	c.1165C>T	c.(1165-1167)Cac>Tac	p.H389Y		NM_024541.2	NP_078817.2	Q5T2E6	CJ076_HUMAN	chromosome 10 open reading frame 76	389						integral to membrane				autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|upper_aerodigestive_tract(2)	24		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		TTGCCACTGTGAAGCCTGTGT	0.378000													14	152					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50946288	50946288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50946288C>T	ENST00000374103.4	-	18	2425	c.2340G>A	c.(2338-2340)gcG>gcA	p.A780A	OGDHL_ENST00000419399.1_Silent_p.A723A|OGDHL_ENST00000490844.1_5'UTR|OGDHL_ENST00000432695.1_Silent_p.A571A	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	780					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding	p.A780A(1)		central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TTTCGGGCCTCGCTGACGAGT	0.617000													13	42					0	0	1	0	0
NCR3	259197	broad.mit.edu	37	6	31560469	31560469	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31560469G>A	ENST00000376073.4	-	1	293	c.30C>T	c.(28-30)atC>atT	p.I10I	NCR3_ENST00000491161.1_Intron|NCR3_ENST00000376072.3_Silent_p.I10I|NCR3_ENST00000376071.4_Silent_p.I10I|NCR3_ENST00000340027.5_Silent_p.I10I	NM_001145466.1	NP_001138938.1	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	10					cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			cervix(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)	9						GATGGACCATGATCAAGATGA	0.587000													5	36					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43971011	43971011	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:43971011T>C	ENST00000282406.4	+	23	3548	c.3438T>C	c.(3436-3438)ttT>ttC	p.F1146F		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1146	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGGAAGAATTTTTGAATACTT	0.388000													19	79					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281254	49281254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:49281254G>A	ENST00000282018.3	+	1	304	c.301G>A	c.(301-303)Ggc>Agc	p.G101S		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	101					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TTATCTTAGAGGCTCCAATTG	0.428000													28	51					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63276414	63276414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:63276414G>A	ENST00000415491.2	+	2	820	c.206G>A	c.(205-207)aGa>aAa	p.R69K	LGALS12_ENST00000340246.5_Missense_Mutation_p.R131K|LGALS12_ENST00000255684.5_Missense_Mutation_p.R130K|LGALS12_ENST00000425950.2_Missense_Mutation_p.R69K|LGALS12_ENST00000394618.3_Missense_Mutation_p.R130K	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	130	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						GCCCTGCGAAGAGGCTCCAGC	0.592000													18	54					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994357	140994357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140994357C>T	ENST00000285879.4	+	4	1453	c.1167C>T	c.(1165-1167)ttC>ttT	p.F389F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	389							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGTCTTTTCCAGAGTTCCC	0.488000										HNSCC(15;0.026)			94	86					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14610413	14610413	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:14610413C>T	ENST00000274217.3	+	8	1181	c.1061C>T	c.(1060-1062)cCa>cTa	p.P354L		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	354										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					TACCACATTCCAGTCTTTTAA	0.532000													15	58					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16339859	16339859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:16339859G>A	ENST00000400202.1	-	3	1367	c.655C>T	c.(655-657)Cct>Tct	p.P219S	NRIP1_ENST00000318948.4_Missense_Mutation_p.P219S|NRIP1_ENST00000400199.1_Missense_Mutation_p.P219S			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	219	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		ACATGATGAGGAGACTCTGCA	0.403000													32	111					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347430	48347430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:48347430C>T	ENST00000319856.4	+	1	959	c.938C>T	c.(937-939)aCc>aTc	p.T313I		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						CTCATTTATACCCTGAGAAAT	0.323000													14	60					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19217149	19217149	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19217149C>T	ENST00000318596.7	+	6	603	c.452C>T	c.(451-453)cCc>cTc	p.P151L	SLC25A42_ENST00000600275.1_3'UTR	NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	151					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			CTGACCTACCCCCTGGACCTG	0.657000													19	53					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7457122	7457122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7457122G>A	ENST00000399422.4	+	1	243	c.195G>A	c.(193-195)aaG>aaA	p.K65K		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	65					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						GGTCCCAAAAGGAGAAGGTAT	0.453000													8	55					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11059542	11059542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11059542C>T	ENST00000287766.4	+	4	673	c.252C>T	c.(250-252)atC>atT	p.I84I	SLC6A1_ENST00000536032.1_Intron|SLC6A1-AS1_ENST00000414969.2_RNA|SLC6A1_ENST00000462473.1_3'UTR	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	84					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCTTCCTGATCCCCTATTTCC	0.602000													19	77					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147929808	147929808	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:147929808C>T	ENST00000360693.3	-	3	182	c.44G>A	c.(43-45)gGg>gAg	p.G15E	HTR4_ENST00000519495.1_5'UTR|HTR4_ENST00000517929.1_Missense_Mutation_p.G15E|HTR4_ENST00000520514.1_Missense_Mutation_p.G15E|HTR4_ENST00000314512.6_Missense_Mutation_p.G15E|HTR4_ENST00000521530.1_Missense_Mutation_p.G15E|HTR4_ENST00000521735.1_Missense_Mutation_p.G15E|HTR4_ENST00000377888.3_Missense_Mutation_p.G15E|HTR4_ENST00000362016.2_Missense_Mutation_p.G15E|HTR4_ENST00000354217.2_Missense_Mutation_p.G15E	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	15					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	CTCCACTGACCCGAAACCCTC	0.498000													19	59					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55839201	55839201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:55839201C>T	ENST00000302000.6	-	3	374	c.280G>A	c.(280-282)Ggt>Agt	p.G94S	PYGO1_ENST00000563719.1_Missense_Mutation_p.G94S	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	94	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		CCAGGATAACCAGGGCCAAGA	0.443000													32	136					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88379651	88379651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:88379651C>T	ENST00000298699.2	-	11	1282	c.1102G>A	c.(1102-1104)Gaa>Aaa	p.E368K	C12orf50_ENST00000550553.1_Missense_Mutation_p.E329K	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	368										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						GGTTTGGGTTCCCTGTTAGCA	0.498000													30	98					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14766127	14766127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:14766127C>T	ENST00000261170.3	-	27	3282	c.3146G>A	c.(3145-3147)cGg>cAg	p.R1049Q	RP11-695J4.2_ENST00000542401.1_RNA|RP11-695J4.2_ENST00000545424.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	1049					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity	p.R1049L(1)		breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						GCTGGCTACCCGTCTGGGTTT	0.428000													69	256					0	0	1	0	0
AES	166	broad.mit.edu	37	19	3055716	3055716	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3055716G>A	ENST00000221561.8	-	5	623	c.444C>T	c.(442-444)atC>atT	p.I148I	AES_ENST00000592330.1_Intron|AES_ENST00000586839.1_Silent_p.I25I|AES_ENST00000327141.4_Silent_p.I81I	NM_198969.1	NP_945320.1	Q08117	AES_HUMAN	amino-terminal enhancer of split	81	Gly/Pro-rich (GP domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			lung(8)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTTTTGACGATCTCAGCCT	0.662000													31	88					0	0	1	0	0
AHSP	51327	broad.mit.edu	37	16	31539891	31539891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31539891G>A	ENST00000302312.4	+	3	291	c.188G>A	c.(187-189)cGa>cAa	p.R63Q	AHSP_ENST00000569954.1_3'UTR	NM_016633.2	NP_057717.1	Q9NZD4	AHSP_HUMAN	alpha hemoglobin stabilizing protein	63					hemoglobin metabolic process|hemopoiesis|protein folding|protein stabilization	hemoglobin complex	hemoglobin binding|unfolded protein binding			lung(2)	2						CCCCAAGAGCGAGACAAGGCT	0.547000													28	41					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178594	65178594	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:65178594C>T	ENST00000310045.7	-	2	4755	c.3282G>A	c.(3280-3282)ttG>ttA	p.L1094L	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1084						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				ATTCTTTCCTCAATGGTTCAT	0.368000													6	50					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56324854	56324854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56324854G>A	ENST00000262290.4	+	4	496	c.180G>A	c.(178-180)atG>atA	p.M60I	LPO_ENST00000421678.2_Intron|LPO_ENST00000543544.1_Start_Codon_SNP_p.M1I|LPO_ENST00000582328.1_Intron	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	60					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						AGACCGCCATGAGCTCTGAGA	0.632000													18	53					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88886058	88886058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:88886058C>T	ENST00000319675.3	-	1	238	c.142G>A	c.(142-144)Gag>Aag	p.E48K		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	48										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						ACACGCAGCTCGCGAGCTATA	0.502000													28	78					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179456933	179456933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179456933C>T	ENST00000589042.1	-	302	59922	c.59698G>A	c.(59698-59700)Gaa>Aaa	p.E19900K	TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E17332K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E18259K|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E11027K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E10960K|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E10835K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18259	Ig-like 110.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGTGGTTCTTTCCAAGTA	0.408000													11	19					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130285592	130285592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:130285592C>T	ENST00000358511.6	+	4	1360	c.1329C>T	c.(1327-1329)ggC>ggT	p.G443G	COL6A6_ENST00000453409.2_Silent_p.G443G	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	443	Nonhelical region.|VWFA 3.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TTATCGATGGCTCAGGGAGCA	0.478000													9	43					0	0	1	0	0
PRKAB2	5565	broad.mit.edu	37	1	146634146	146634146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:146634146G>A	ENST00000254101.3	-	6	683	c.545C>T	c.(544-546)tCc>tTc	p.S182F	PRKAB2_ENST00000425272.2_Missense_Mutation_p.S100F	NM_005399.3	NP_005390.1	O43741	AAKB2_HUMAN	protein kinase, AMP-activated, beta 2 non-catalytic subunit	182					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				NS(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	GGGTGAGCTGGAAAGGTCTGA	0.393000													7	37					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82507161	82507161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:82507161G>A	ENST00000268206.7	-	15	1815	c.1647C>T	c.(1645-1647)ctC>ctT	p.L549L	EFTUD1_ENST00000359445.3_Silent_p.L498L	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	549					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						GGACTTGGGGGAGGCCATCTG	0.473000													23	60					0	0	1	0	0
PODXL	5420	broad.mit.edu	37	7	131189133	131189133	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:131189133C>T	ENST00000541194.1	-	9	1877	c.1620G>A	c.(1618-1620)tgG>tgA	p.W540*	PODXL_ENST00000322985.9_Nonsense_Mutation_p.W506*|PODXL_ENST00000537928.1_Nonsense_Mutation_p.W506*|PODXL_ENST00000378555.3_Nonsense_Mutation_p.W538*	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	538					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					GAGGGACGATCCAGCTGTCCC	0.582000													23	94					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104778670	104778670	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:104778670G>A	ENST00000406091.3	+	3	603	c.603G>A	c.(601-603)gtG>gtA	p.V201V		NM_001100117.2	NP_001093587.1	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	232					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TACCTGCAGTGGAGAAAAGTC	0.473000										HNSCC(12;0.0054)			14	61					0	0	1	0	0
TRAV12-1	28674	broad.mit.edu	37	14	22309848	22309848	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22309848G>A	ENST00000390433.1	+	0	232																											CAGTGGTAATGAAGATGGAAG	0.463000													31	99					0	0	1	0	0
URM1	81605	broad.mit.edu	37	9	131140306	131140306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131140306C>T	ENST00000372847.1	+	2	78	c.68C>T	c.(67-69)tCc>tTc	p.S23F	URM1_ENST00000372850.1_Intron|URM1_ENST00000372853.4_Intron|URM1_ENST00000452446.1_Intron			Q9BTM9	URM1_HUMAN	ubiquitin related modifier 1	0					tRNA thio-modification|tRNA wobble uridine modification		protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)	5						CTCTGGTCCTCCTTTGCAGAG	0.502000													19	55					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163693182	163693182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163693182C>T	ENST00000332142.5	-	2	271	c.172G>A	c.(172-174)Gat>Aat	p.D58N	KCNH7_ENST00000328032.4_Missense_Mutation_p.D58N	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	58	PAS.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGCATGACATCTGGCCTGGAG	0.468000													34	51					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32259443	32259443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:32259443C>T	ENST00000360482.2	-	12	2568	c.2439G>A	c.(2437-2439)ggG>ggA	p.G813G	SPOCD1_ENST00000533231.1_Silent_p.G813G|SPOCD1_ENST00000373648.2_3'UTR|SPOCD1_ENST00000257100.3_Silent_p.G306G	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	813					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		AGATATTGTCCCCGCAGCTCT	0.577000													55	185					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40411717	40411717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40411717C>T	ENST00000221347.6	-	7	3918	c.3911G>A	c.(3910-3912)cGa>cAa	p.R1304Q		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1304	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CACACTGACTCGCCCATTACC	0.627000													55	114					0	0	1	0	0
SPDYE4	388333	broad.mit.edu	37	17	8656701	8656701	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:8656701G>A	ENST00000328794.6	-	5	768	c.592C>T	c.(592-594)Cga>Tga	p.R198*		NM_001128076.1	NP_001121548.1	A6NLX3	SPDE4_HUMAN	speedy/RINGO cell cycle regulator family member E4	198										breast(1)|endometrium(2)|kidney(1)	4						AGCTGGTATCGAAGCTTATGG	0.587000													3	7					0	0	1	0	0
PGF	5228	broad.mit.edu	37	14	75416173	75416173	+	Missense_Mutation	SNP	C	C	T	rs143175863		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75416173C>T	ENST00000555567.1	-	3	743	c.202G>A	c.(202-204)Gag>Aag	p.E68K	PGF_ENST00000553716.1_Missense_Mutation_p.E68K|PGF_ENST00000238607.6_Missense_Mutation_p.E67K|PGF_ENST00000405431.2_Missense_Mutation_p.E68K	NM_002632.5	NP_002623.2	P49763	PLGF_HUMAN	placental growth factor	68					angiogenesis|cell differentiation|cell-cell signaling|positive regulation of cell division|positive regulation of cell proliferation|vascular endothelial growth factor receptor signaling pathway	extracellular region|membrane	growth factor activity|heparin binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(234;0.00668)		TGCTCCACCTCGCTGGGGTAC	0.652000													7	20					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153217341	153217341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:153217341G>A	ENST00000310441.7	-	20	6177	c.5211C>T	c.(5209-5211)gcC>gcT	p.A1737A	HCFC1_ENST00000369984.4_Silent_p.A1782A|HCFC1_ENST00000354233.3_Silent_p.A1668A	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	1737					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGACCGTGCCGGCCAGCTCAT	0.657000													22	7					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81373758	81373758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81373758C>T	ENST00000398636.3	+	6	774	c.636C>T	c.(634-636)taC>taT	p.Y212Y	SFTPA1_ENST00000428376.2_Silent_p.Y212Y|SFTPA1_ENST00000372308.3_Silent_p.Y212Y|SFTPA1_ENST00000419470.2_Silent_p.Y227Y|SFTPA1_ENST00000372313.5_Silent_p.Y153Y	NM_001164644.1|NM_001164646.1|NM_005411.4	NP_001158116.1|NP_001158118.1|NP_005402.3	Q8IWL2	SFTA1_HUMAN	surfactant protein A1	212	C-type lectin.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			CCAACTGGTACCGAGGGGAGC	0.557000													95	191					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51387787	51387787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51387787C>T	ENST00000266037.9	+	40	4094	c.4071C>T	c.(4069-4071)gtC>gtT	p.V1357V		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1357	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCTTTCGGGTCGGCTTCTATG	0.438000													49	115					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91498068	91498068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:91498068G>A	ENST00000266718.4	-	3	1345	c.891C>T	c.(889-891)atC>atT	p.I297I	LUM_ENST00000548071.1_5'UTR	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	297					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						ATGGCCCCAGGATCTTGCAGA	0.368000													17	50					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474636	140474636	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140474636T>G	ENST00000194155.4	+	1	410	c.262T>G	c.(262-264)Tta>Gta	p.L88V		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		88	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGATTTGTTGTTAAATGAGAA	0.512000													43	93					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2963962	2963962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:2963962G>A	ENST00000396946.4	-	15	2248	c.1845C>T	c.(1843-1845)tcC>tcT	p.S615S		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	615					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		AGGAGTGGATGGAGGAGGGTC	0.612000			Mis		DLBCL								32	59					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21036173	21036173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:21036173G>A	ENST00000247986.2	-	4	939	c.629C>T	c.(628-630)tCg>tTg	p.S210L	KIF17_ENST00000400463.3_Missense_Mutation_p.S210L|KIF17_ENST00000375044.1_Missense_Mutation_p.S110L			Q9P2E2	KIF17_HUMAN	kinesin family member 17	210	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GATGGAGTGCGAGCGTGAGGA	0.592000													11	95					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149073664	149073664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:149073664C>T	ENST00000355292.3	-	6	2840	c.2478G>A	c.(2476-2478)acG>acA	p.T826T	NR3C2_ENST00000344721.4_Silent_p.T822T|NR3C2_ENST00000342437.4_Intron|NR3C2_ENST00000503313.1_5'UTR|NR3C2_ENST00000511528.1_Silent_p.T826T|NR3C2_ENST00000512865.1_Silent_p.T705T|NR3C2_ENST00000358102.3_Silent_p.T822T|RP11-76G10.1_ENST00000514843.1_RNA			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	822	Steroid-binding.		F -> Y (in dbSNP:rs13306592).		regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding	p.T822T(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ATTGGCTGTTCGTATGTTTGT	0.363000													27	73					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11285177	11285177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:11285177G>A	ENST00000432929.2	-	9	2424	c.2064C>T	c.(2062-2064)ttC>ttT	p.F688F	KANK2_ENST00000355150.5_Silent_p.F680F|KANK2_ENST00000586659.1_Silent_p.F680F|KANK2_ENST00000589359.1_Silent_p.F688F|KANK2_ENST00000589894.1_Silent_p.F680F	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	680										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCACCACGGGGAAGTTGGCAT	0.642000													4	19					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122664264	122664264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:122664264C>T	ENST00000263461.6	+	25	3380	c.3134C>T	c.(3133-3135)cCc>cTc	p.P1045L	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	1045						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						TCGTCAGGCCCCTCTCAGAGC	0.443000													39	81					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114275979	114275979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:114275979C>T	ENST00000357077.4	+	38	6258	c.6205C>T	c.(6205-6207)Cgt>Tgt	p.R2069C	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.R2036C|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2036					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGAGGAGTTCGTGTTTCCTC	0.468000													76	50					0	0	1	0	0
STAC2	342667	broad.mit.edu	37	17	37374290	37374290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:37374290G>A	ENST00000333461.5	-	2	596	c.227C>T	c.(226-228)cCt>cTt	p.P76L		NM_198993.3	NP_945344.1	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	76	Pro-rich.				intracellular signal transduction		metal ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(2)	17						TGGGGAGGGAGGGGGCAGTGG	0.667000													4	7					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37916554	37916554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:37916554G>A	ENST00000199447.4	+	12	1311	c.939G>A	c.(937-939)atG>atA	p.M313I	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.M313I	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	313					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										TGAAAAGCATGAAATTAGAAA	0.343000													16	58					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231189	21231189	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21231189C>T	ENST00000233242.1	-	26	8678	c.8551G>A	c.(8551-8553)Gag>Aag	p.E2851K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2851					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATTTTCCCTCAATAGCATTT	0.413000													58	220					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10222127	10222127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10222127C>T	ENST00000418404.3	-	26	3881	c.3718G>A	c.(3718-3720)Gag>Aag	p.E1240K	MYH13_ENST00000570743.1_Missense_Mutation_p.E1240K|MYH13_ENST00000252172.4_Missense_Mutation_p.E1240K			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1240					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.E1240K(2)		breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GAGAGAGCCTCGATGTTGCTG	0.567000													44	46					0	0	1	0	0
CLU	1191	broad.mit.edu	37	8	27463978	27463978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27463978C>T	ENST00000316403.10	-	4	715	c.310G>A	c.(310-312)Gag>Aag	p.E104K	CLU_ENST00000523500.1_Missense_Mutation_p.E104K|CLU_ENST00000546343.1_Missense_Mutation_p.E115K|CLU_ENST00000560366.1_Missense_Mutation_p.E156K|CLU_ENST00000405140.3_Missense_Mutation_p.E104K			P10909	CLUS_HUMAN	clusterin	104					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		ATCATGGTCTCATTGCACACT	0.552000													51	145					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56271342	56271342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56271342G>A	ENST00000225371.5	+	5	593	c.483G>A	c.(481-483)ggG>ggA	p.G161G		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	161					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding	p.G161G(1)		breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						CCTTGCTAGGGGCCTCCAACC	0.667000													15	40					0	0	1	0	0
ICAM4	3386	broad.mit.edu	37	19	10397994	10397994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10397994C>T	ENST00000393717.2	+	1	315	c.306C>T	c.(304-306)ctC>ctT	p.L102L	ICAM4_ENST00000380770.3_Silent_p.L102L|CTD-2369P2.8_ENST00000589379.1_RNA|ICAM4_ENST00000340992.4_Silent_p.L102L	NM_022377.3	NP_071772.1	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	102	Ig-like C2-type 1.				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			breast(1)|large_intestine(3)|lung(2)|pancreas(1)	7			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			ACCAGCTGCTCGACGTGAGGG	0.662000													11	19					0	0	1	0	0
ABAT	18	broad.mit.edu	37	16	8862729	8862729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:8862729C>T	ENST00000396600.2	+	11	1653	c.715C>T	c.(715-717)Cct>Tct	p.P239S	ABAT_ENST00000569156.1_Missense_Mutation_p.P239S|ABAT_ENST00000425191.2_Missense_Mutation_p.P239S|ABAT_ENST00000567812.1_Missense_Mutation_p.P254S|ABAT_ENST00000268251.8_Missense_Mutation_p.P239S	NM_000663.4	NP_000654.2	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase	239					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	26					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	GATCGACATCCCTTCCTTTGA	0.527000													32	300					0	0	1	0	0
CLDN14	23562	broad.mit.edu	37	21	37833570	37833570	+	Missense_Mutation	SNP	C	C	T	rs146755542	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:37833570C>T	ENST00000399137.1	-	3	1290	c.424G>A	c.(424-426)Gac>Aac	p.D142N	AP000695.4_ENST00000428667.1_RNA|CLDN14_ENST00000342108.2_Missense_Mutation_p.D142N|CLDN14_ENST00000399139.1_Missense_Mutation_p.D142N|CLDN14_ENST00000399136.1_Missense_Mutation_p.D142N|AP000695.6_ENST00000429588.1_RNA|CLDN14_ENST00000399135.1_Missense_Mutation_p.D142N	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	142					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						TGCACCACGTCGTTGGTGGTC	0.627000													27	83					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102302440	102302440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:102302440C>T	ENST00000370103.4	-	2	424	c.211G>A	c.(211-213)Gaa>Aaa	p.E71K	OLFM3_ENST00000359814.3_Missense_Mutation_p.E91K|OLFM3_ENST00000338858.5_Missense_Mutation_p.E91K|OLFM3_ENST00000536598.1_5'UTR|OLFM3_ENST00000462354.1_5'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	91						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CCTACCTTTTCCAGTAGTTGG	0.448000													53	101					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810959	65810959	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65810959G>A	ENST00000312006.4	-	3	596	c.315C>T	c.(313-315)ttC>ttT	p.F105F	GAL3ST3_ENST00000527878.1_Silent_p.F105F	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	105					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GGGGGTAGCAGAACTGGTGCT	0.687000													12	24					0	0	1	0	0
JSRP1	126306	broad.mit.edu	37	19	2252699	2252699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2252699C>T	ENST00000300961.5	-	7	689	c.625G>A	c.(625-627)Gag>Aag	p.E209K	JSRP1_ENST00000586471.1_Missense_Mutation_p.E209K	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	209						sarcoplasmic reticulum membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGTCGTTCTCTGCAGCCTCC	0.706000													28	113					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134627674	134627674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:134627674C>T	ENST00000368586.5	-	54	7470	c.7370G>A	c.(7369-7371)gGa>gAa	p.G2457E	TTC40_ENST00000263170.5_Missense_Mutation_p.G618E	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	618										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						GTGCTTGCTTCCCAGATGTCC	0.587000													12	39					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688288	60688288	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:60688288C>T	ENST00000335712.6	-	4	1986	c.1759G>A	c.(1759-1761)Gaa>Aaa	p.E587K	BCL11A_ENST00000538214.1_Missense_Mutation_p.E553K|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000356842.4_Missense_Mutation_p.E587K|BCL11A_ENST00000537768.1_Missense_Mutation_p.E256K|BCL11A_ENST00000358510.4_Missense_Mutation_p.E553K	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	587					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACCGAGTCTTCGTCGCAAGTG	0.672000			T	IGH@	B-CLL								15	26					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44272158	44272158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:44272158C>T	ENST00000315087.7	-	3	945	c.285G>A	c.(283-285)atG>atA	p.M95I	ST8SIA5_ENST00000538168.1_Missense_Mutation_p.M131I|ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000536490.1_Missense_Mutation_p.M64I	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	95					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						CAGAGATGTTCATCGCCCATT	0.507000													21	59					0	0	1	0	0
HNRNPL	3191	broad.mit.edu	37	19	39336578	39336578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39336578G>A	ENST00000221419.5	-	3	905	c.539C>T	c.(538-540)tCc>tTc	p.S180F	HNRNPL_ENST00000600873.1_Missense_Mutation_p.S47F	NM_001533.2	NP_001524.2	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	180					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CCCAGGGCGGGAGATCTTCTG	0.542000													44	109					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34118537	34118537	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:34118537C>T	ENST00000297161.2	+	13	1521	c.1147C>T	c.(1147-1149)Cag>Tag	p.Q383*	BMPER_ENST00000426693.1_Nonsense_Mutation_p.Q383*	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	383	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						ATTTAACTTTCAGGGGACGTG	0.572000													53	137					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760871	20760871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20760871C>T	ENST00000400451.2	+	5	2062	c.1548C>T	c.(1546-1548)atC>atT	p.I516I	ZNF74_ENST00000405993.1_Silent_p.I484I|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Silent_p.I516I	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	516					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGTCCCTCATCGTGCACCAGC	0.592000													32	98					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104144428	104144428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104144428C>T	ENST00000388887.2	+	60	6714	c.6510C>T	c.(6508-6510)ccC>ccT	p.P2170P	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2170					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGCAGCTGCCCATTGACCGCT	0.552000													18	52					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10255195	10255195	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:10255195G>A	ENST00000256458.4	+	6	841	c.751G>A	c.(751-753)Gaa>Aaa	p.E251K		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	251	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						AGGATCAATCGAAAGATTCTT	0.468000													9	102					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5221023	5221023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:5221023G>A	ENST00000372412.4	-	20	3679	c.3446C>T	c.(3445-3447)cCc>cTc	p.P1149L	PTPRS_ENST00000588012.1_Missense_Mutation_p.P1126L|PTPRS_ENST00000357368.4_Missense_Mutation_p.P1148L|PTPRS_ENST00000353284.2_Missense_Mutation_p.P717L|PTPRS_ENST00000348075.2_Missense_Mutation_p.P1126L|PTPRS_ENST00000592099.1_Missense_Mutation_p.P717L|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000587303.1_Missense_Mutation_p.P1148L|PTPRS_ENST00000262963.6_Missense_Mutation_p.P1144L			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1148					cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GACAGGCACGGGGCTCTGGCC	0.622000													38	99					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55340191	55340191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55340191C>T	ENST00000314634.3	+	1	588	c.588C>T	c.(586-588)ctC>ctT	p.L196L		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				TTAACCTACTCCTGGTTTCCA	0.443000													33	72					0	0	1	0	0
PEX2	5828	broad.mit.edu	37	8	77896041	77896041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77896041C>T	ENST00000419564.2	-	4	838	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	PEX2_ENST00000522527.1_Missense_Mutation_p.R125Q|PEX2_ENST00000520103.1_Missense_Mutation_p.R125Q|PEX2_ENST00000357039.4_Missense_Mutation_p.R125Q	NM_001172087.1	NP_001165558.1	P28328	PEX2_HUMAN	peroxisomal biogenesis factor 2	125					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	14						ATGATGGTTTCGAAACAAATC	0.363000													35	88					0	0	1	0	0
FAM92A1P2	403315	broad.mit.edu	37	4	183959078	183959078	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183959078G>A	ENST00000502308.1	+	0	261					NR_003612.1																						GAGGATGAATGAAATCAACTC	0.473000													5	8					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233190032	233190032	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233190032G>A	ENST00000258229.8	-	25	4567	c.4333C>T	c.(4333-4335)Cga>Tga	p.R1445*	PCNXL2_ENST00000344698.2_Nonsense_Mutation_p.R97*	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1445						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TCCAGTCCTCGAAGTTGAAAG	0.388000													9	27					0	0	1	0	0
F2RL1	2150	broad.mit.edu	37	5	76128799	76128799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:76128799C>T	ENST00000296677.4	+	2	573	c.367C>T	c.(367-369)Ctc>Ttc	p.L123F		NM_005242.4	NP_005233.3	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	123					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		GGCTGACCTCCTCTCTGTCAT	0.463000													70	290					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179620142	179620142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:179620142C>T	ENST00000444136.1	+	12	2191	c.1941C>T	c.(1939-1941)ttC>ttT	p.F647F	TDRD5_ENST00000367614.1_Silent_p.F647F|TDRD5_ENST00000294848.8_Silent_p.F647F	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	647					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						ATGTCTATTTCCATCATGTCT	0.383000													50	123					0	0	1	0	0
SLC36A4	120103	broad.mit.edu	37	11	92881964	92881964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:92881964G>A	ENST00000326402.4	-	11	1384	c.1254C>T	c.(1252-1254)ttC>ttT	p.F418F	SLC36A4_ENST00000529184.1_Silent_p.F283F	NM_152313.2	NP_689526.2	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 4	418					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	25		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CAGCTCCAACGAAGGAAATCA	0.363000													6	101					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17198952	17198952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:17198952C>T	ENST00000180173.5	-	6	686	c.652G>A	c.(652-654)Gag>Aag	p.E218K	MTMR7_ENST00000521857.1_Missense_Mutation_p.E218K|MTMR7_ENST00000523571.1_5'UTR	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	218	Myotubularin phosphatase.						protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		TGCTCGTCCTCTAGGCACCGG	0.572000													11	38					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57313798	57313798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:57313798G>A	ENST00000457912.1	+	6	1220	c.1220G>A	c.(1219-1221)cGa>cAa	p.R407Q	SMTNL1_ENST00000399154.2_Missense_Mutation_p.R352Q|SMTNL1_ENST00000527972.1_Missense_Mutation_p.R389Q			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	389										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						GAGTGGTGCCGAGCCATGACA	0.622000													5	16					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104596855	104596855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104596855C>T	ENST00000369887.3	-	1	435	c.264G>A	c.(262-264)aaG>aaA	p.K88K	CYP17A1_ENST00000489268.1_5'UTR	NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	88					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	CCTTGCCCTTCTTAATAAGCA	0.547000													34	81					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240071103	240071103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:240071103G>A	ENST00000255380.4	+	5	1131	c.352G>A	c.(352-354)Ggg>Agg	p.G118R		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	118					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TCTGATTATCGGGGTCATTTC	0.478000													20	51					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33027990	33027990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:33027990C>T	ENST00000374864.4	+	9	923	c.710C>T	c.(709-711)tCt>tTt	p.S237F	ITCH_ENST00000535650.1_Missense_Mutation_p.S127F|ITCH_ENST00000262650.6_Missense_Mutation_p.S278F	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	278					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						TCTGCCACTTCTGAAAGTGAT	0.358000													10	60					0	0	1	0	0
GPX3	2878	broad.mit.edu	37	5	150407676	150407676	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150407676G>A	ENST00000388825.4	+	5	758	c.666G>A	c.(664-666)ggG>ggA	p.G222G	GPX3_ENST00000517973.1_3'UTR	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	222					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CAGCCCTGGGGGTCAAGAGGA	0.562000													3	5					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139653178	139653178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139653178C>T	ENST00000263552.6	+	10	1003	c.465C>T	c.(463-465)ctC>ctT	p.L155L	TBXAS1_ENST00000448866.1_Silent_p.L154L|TBXAS1_ENST00000436047.2_Silent_p.L155L|TBXAS1_ENST00000414508.2_Silent_p.L155L|TBXAS1_ENST00000416849.2_Silent_p.L201L|TBXAS1_ENST00000425687.1_Silent_p.L87L|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000411653.1_Silent_p.L154L|TBXAS1_ENST00000458722.1_Silent_p.L200L|TBXAS1_ENST00000336425.5_Silent_p.L154L	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	154					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					TGGTTCCCCTCATCAGCCAAG	0.473000													23	80					0	0	1	0	0
PLAU	5328	broad.mit.edu	37	10	75676148	75676148	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75676148G>A	ENST00000446342.1	+	10	1552	c.1068_splice	c.e10-1	p.G357_splice	PLAU_ENST00000372762.4_Splice_Site_p.G338_splice|PLAU_ENST00000372764.3_Splice_Site_p.G374_splice|C10orf55_ENST00000412307.2_Intron|C10orf55_ENST00000409178.1_Intron	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	374	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	GCGTCACAGGGAGACTCAGGG	0.557000													5	20					0	0	1	0	0
HARS2	23438	broad.mit.edu	37	5	140075096	140075096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140075096C>T	ENST00000230771.3	+	5	626	c.403C>T	c.(403-405)Ccc>Tcc	p.P135S	HARS2_ENST00000435019.2_Missense_Mutation_p.P95S|HARS2_ENST00000448069.2_Intron|HARS2_ENST00000502303.1_3'UTR|HARS2_ENST00000432671.2_Intron|HARS2_ENST00000437649.2_Intron|HARS2_ENST00000508522.1_Missense_Mutation_p.P110S	NM_012208.2	NP_036340.1	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2, mitochondrial	135					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity			NS(1)|endometrium(3)|large_intestine(5)|lung(10)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTGAGGTTCCCTTTGCTCG	0.488000													61	194					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55110701	55110701	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55110701G>A	ENST00000453777.1	+	6	832	c.661_splice	c.e6-1	p.G221_splice	LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000251372.3_Splice_Site_p.G421_splice|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	221	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		TGATTCTCAGGAGCAGCTGAG	0.448000													15	47					0	0	1	0	0
SPAG1	6674	broad.mit.edu	37	8	101206358	101206358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:101206358G>A	ENST00000388798.2	+	10	1149	c.958G>A	c.(958-960)Gaa>Aaa	p.E320K	SPAG1_ENST00000251809.3_Missense_Mutation_p.E320K|SPAG1_ENST00000520508.1_Missense_Mutation_p.E320K|SPAG1_ENST00000520643.1_Missense_Mutation_p.E320K	NM_003114.4	NP_003105.2	Q07617	SPAG1_HUMAN	sperm associated antigen 1	320					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		GTCAGAGGTTGAAAGAGATCT	0.313000													11	52					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151263	158151263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158151263C>T	ENST00000368171.3	+	3	579	c.80C>T	c.(79-81)cCc>cTc	p.P27L		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	27					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					AGGCTTTTCCCCCTCCGCTGC	0.592000													141	368					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991597	70991597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:70991597G>A	ENST00000256389.3	-	2	272	c.28C>T	c.(28-30)Ccc>Tcc	p.P10S	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	0					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GGGATCTGGGGATCTGTGTCC	0.532000													45	100					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319497	21319497	+	Silent	SNP	C	C	T	rs139358757	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:21319497C>T	ENST00000583088.1	+	3	1738	c.843C>T	c.(841-843)ttC>ttT	p.F281F	KCNJ12_ENST00000331718.5_Silent_p.F281F	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.F281F(1)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GCCCGCTCTTCGGCATCAGCC	0.607000										Prostate(3;0.18)			10	66					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92488054	92488054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:92488054G>A	ENST00000267622.4	-	4	807	c.434C>T	c.(433-435)tCa>tTa	p.S145L		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	145					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		ATAAGCGAATGAAGATGATGC	0.458000			T	PDGFRB	AML								21	41					0	0	1	0	0
RP11-483E23.2	0	broad.mit.edu	37	15	28600112	28600112	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:28600112C>T	ENST00000568624.1	-	0	382																											CTCTAGCTCCCTCCTTAGGGC	0.507000													8	60					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45798380	45798380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:45798380G>A	ENST00000357450.4	-	5	686	c.687C>T	c.(685-687)taC>taT	p.Y229Y	SMC1B_ENST00000404354.3_Silent_p.Y229Y	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	229					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TCTCATTATGGTATAGTTGAA	0.358000													49	111					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103057146	103057146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103057146G>A	ENST00000375735.2	+	42	6953	c.6809G>A	c.(6808-6810)cGa>cAa	p.R2270Q	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.R2270Q	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2270	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GACATGCAACGAGGTCTAGAT	0.408000													19	51					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173569281	173569281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173569281C>T	ENST00000367714.3	-	3	625	c.203G>A	c.(202-204)gGa>gAa	p.G68E	RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000536496.1_Intron	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	68					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										GGCCATGTGTCCTATCACGAA	0.348000													9	74					0	0	1	0	0
LRRC25	126364	broad.mit.edu	37	19	18507007	18507007	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18507007C>T	ENST00000339007.3	-	1	1420	c.767G>A	c.(766-768)tGg>tAg	p.W256*	LRRC25_ENST00000595840.1_Nonsense_Mutation_p.W256*	NM_145256.2	NP_660299.2	Q8N386	LRC25_HUMAN	leucine rich repeat containing 25	256						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|skin(1)	8						TTGTTCATCCCACTGGTGCTC	0.597000													20	83					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531185	140531185	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140531185C>T	ENST00000231136.1	+	1	1347	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F	PCDHB6_ENST00000543635.1_Silent_p.F313F	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		449	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCCGCCTTCACCCAAACCT	0.582000													72	176					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107360822	107360822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:107360822C>T	ENST00000374779.2	-	1	966	c.873G>A	c.(871-873)atG>atA	p.M291I		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						TTAAAGGATTCATCATGGGAG	0.373000													6	82					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887095	9887095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:9887095G>A	ENST00000306084.6	+	2	818	c.619G>A	c.(619-621)Ggt>Agt	p.G207S	TXNDC2_ENST00000357775.4_Missense_Mutation_p.G140S|TXNDC2_ENST00000536353.2_Intron	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	207	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GCCCAAAGAGGGTGACATCCC	0.567000													55	170					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36677252	36677252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:36677252G>A	ENST00000265113.4	+	6	1302	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K	SLC1A3_ENST00000381918.3_Missense_Mutation_p.E276K|CTD-2353F22.1_ENST00000510740.1_RNA	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	276					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TTCTCTTAACGAAGCCATCAT	0.413000													32	62					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10971322	10971322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:10971322C>T	ENST00000298232.7	-	5	402	c.35G>A	c.(34-36)gGa>gAa	p.G12E	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.G12E|TPTE_ENST00000361285.4_Missense_Mutation_p.G12E	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	12					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATGATGACTCCCGCCAGGTC	0.453000													10	62					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49094946	49094946	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49094946G>A	ENST00000395443.2	-	3	1159	c.687C>T	c.(685-687)ccC>ccT	p.P229P	QRICH1_ENST00000479449.1_Intron|QRICH1_ENST00000357496.2_Silent_p.P229P|QRICH1_ENST00000424300.1_Silent_p.P229P	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	229	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CCCCTTCCCGGGGTGAGCCCT	0.632000													24	45					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759655	6759655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:6759655G>A	ENST00000378827.4	+	3	2329	c.1110G>A	c.(1108-1110)tcG>tcA	p.S370S		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	370					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GTGCTATCTCGATGCTGTACC	0.428000													15	50					0	0	1	0	0
STK40	83931	broad.mit.edu	37	1	36823848	36823848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:36823848G>A	ENST00000359297.2	-	3	341	c.334C>T	c.(334-336)Ctc>Ttc	p.L112F	STK40_ENST00000373129.3_Missense_Mutation_p.L112F|STK40_ENST00000373130.3_Missense_Mutation_p.L117F|STK40_ENST00000373132.3_Missense_Mutation_p.L112F|STK40_ENST00000482458.1_5'UTR			Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	112	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)	13		Myeloproliferative disorder(586;0.0393)				ACCTGGAAGAGGCCGTGGTGG	0.647000													25	27					0	0	1	0	0
WDR16	146845	broad.mit.edu	37	17	9515755	9515755	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:9515755G>A	ENST00000352665.5	+	8	1053	c.984G>A	c.(982-984)gcG>gcA	p.A328A	WDR16_ENST00000299764.5_Silent_p.A338A|WDR16_ENST00000396219.3_Silent_p.A260A	NM_145054.4	NP_659491.4	Q8N1V2	WDR16_HUMAN	WD repeat domain 16	328						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31						CGCTCATAGCGACTTGTCACT	0.433000													22	31					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901192	51901192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:51901192C>T	ENST00000268919.4	+	1	954	c.798C>T	c.(796-798)ttC>ttT	p.F266F		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	266	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CCTTCTGCTTCGACCATGCCT	0.557000													5	69					0	0	1	0	0
PARVA	55742	broad.mit.edu	37	11	12539227	12539227	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12539227T>C	ENST00000334956.8	+	11	1401	c.1058T>C	c.(1057-1059)tTc>tCc	p.F353S	PARVA_ENST00000539723.1_Missense_Mutation_p.F313S|PARVA_ENST00000550549.1_Missense_Mutation_p.F313S	NM_018222.4	NP_060692.2	Q9NVD7	PARVA_HUMAN	parvin, alpha	313	CH 2.				cell adhesion|cell junction assembly|cilium morphogenesis	actin cytoskeleton|cytosol|focal adhesion	actin binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)	11				Epithelial(150;0.00624)		CTGCACAGCTTCTTCCTGACC	0.597000													3	13					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940488	144940488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144940488C>T	ENST00000525985.1	-	2	7005	c.6934G>A	c.(6934-6936)Gac>Aac	p.D2312N				P58107	EPIPL_HUMAN	epiplakin 1	2312						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTGTAGGGGTCGGTGTAGCCG	0.701000													14	300					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139428696	139428696	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:139428696C>T	ENST00000272641.3	-	2	697	c.591G>A	c.(589-591)gcG>gcA	p.A197A		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	197	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		CGGTCTTTTTCGCCCGATCTG	0.488000													13	25					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55174690	55174690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55174690C>T	ENST00000414150.2	+	23	3949	c.3671C>T	c.(3670-3672)tCc>tTc	p.S1224F	MROH7_ENST00000409996.1_Missense_Mutation_p.S792F|MROH7_ENST00000454855.2_Missense_Mutation_p.S742F|MROH7_ENST00000421030.2_Missense_Mutation_p.S1224F					maestro heat-like repeat family member 7																		GCTCAAGGGTCCCTGGTCCCC	0.522000													29	93					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767332	77767332	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:77767332G>A	ENST00000521891.2	+	10	8623	c.8175G>A	c.(8173-8175)caG>caA	p.Q2725Q	ZFHX4_ENST00000455469.2_Silent_p.Q2680Q|ZFHX4_ENST00000050961.6_Silent_p.Q2680Q|ZFHX4_ENST00000518282.1_Silent_p.Q2699Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2680						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAGCCCACAGAAATACATCT	0.428000										HNSCC(33;0.089)			5	29					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6932137	6932137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:6932137C>T	ENST00000383032.1	+	8	1051	c.404C>T	c.(403-405)cCa>cTa	p.P135L	TBL1Y_ENST00000346432.3_Missense_Mutation_p.P135L|TBL1Y_ENST00000355162.2_Missense_Mutation_p.P135L	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	135					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						CAAAATCCTCCAAAGAACCGA	0.547000													23	14					0	0	1	0	0
RND3	390	broad.mit.edu	37	2	151328151	151328151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:151328151G>A	ENST00000375734.2	-	4	722	c.473C>T	c.(472-474)tCc>tTc	p.S158F	RND3_ENST00000263895.4_Missense_Mutation_p.S158F|RND3_ENST00000409557.1_Missense_Mutation_p.S29F|RND3_ENST00000472416.1_Intron	NM_001254738.1	NP_001241667.1	P61587	RND3_HUMAN	Rho family GTPase 3	158					actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.106)		CTGGTCATAGGACACTGGCGT	0.408000													11	168					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49295430	49295430	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:49295430C>T	ENST00000406846.2	-	2	272		c.e2-1		FSHR_ENST00000346173.3_Splice_Site|FSHR_ENST00000304421.4_Splice_Site	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor						female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GACAAACCTCCTGCAAAGAGA	0.383000									Gonadal Dysgenesis, 46 XX				11	104					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59971154	59971154	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:59971154G>A	ENST00000444766.3	-	13	1769	c.1694C>T	c.(1693-1695)tCc>tTc	p.S565F	INTS2_ENST00000251334.6_Missense_Mutation_p.S557F	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	565					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						CTTGGTAAAGGAACGGCTCCT	0.378000													6	12					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32811801	32811801	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:32811801C>T	ENST00000380250.3	+	44	6592	c.6096C>T	c.(6094-6096)tcC>tcT	p.S2032S		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2032					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CGGACCCATCCCACATAAACC	0.498000													7	27					0	0	1	0	0
GPBP1	65056	broad.mit.edu	37	5	56527007	56527007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:56527007C>T	ENST00000424459.3	+	5	1544	c.270C>T	c.(268-270)taC>taT	p.Y90Y	GPBP1_ENST00000538707.1_Silent_p.Y97Y|GPBP1_ENST00000264779.6_Silent_p.Y97Y|GPBP1_ENST00000514387.2_5'UTR|GPBP1_ENST00000506184.2_Silent_p.Y90Y|GPBP1_ENST00000454432.2_Silent_p.Y90Y|GPBP1_ENST00000511209.1_Silent_p.Y97Y	NM_022913.3	NP_075064.1	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	19		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		GAGGTGGATACCATGGTGGAA	0.398000													6	86					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66190265	66190265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:66190265G>A	ENST00000311034.2	+	4	727	c.551G>A	c.(550-552)gGa>gAa	p.G184E		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	184					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						TACTGGGCAGGAAATCCCGTG	0.622000													41	92					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103908622	103908622	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103908622C>T	ENST00000278070.2	+	12	4705	c.4666C>T	c.(4666-4668)Cga>Tga	p.R1556*	PPRC1_ENST00000370012.1_Nonsense_Mutation_p.R523*|PPRC1_ENST00000489648.1_3'UTR|PPRC1_ENST00000413464.2_Nonsense_Mutation_p.R1292*	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1556	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CCGCATGACTCGATCAGAGCT	0.488000													23	42					0	0	1	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17369021	17369021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:17369021G>A	ENST00000377602.4	-	6	701	c.627C>T	c.(625-627)ttC>ttT	p.F209F		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	209					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						ACCTAAAAACGAAGTCGGATT	0.383000													30	51					0	0	1	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228679	57228679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57228679C>T	ENST00000396721.2	-	2	358	c.228G>A	c.(226-228)ggG>ggA	p.G76G	SDR16C5_ENST00000303749.3_Silent_p.G76G|SDR16C5_ENST00000522671.1_Silent_p.G76G			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	76					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						TTTCCTCATTCCCCTCCTTAT	0.522000													17	112					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29455197	29455197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29455197C>T	ENST00000389048.3	-	15	3511	c.2605G>A	c.(2605-2607)Ggg>Agg	p.G869R	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	869	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCGTTTAGCCCTAGAACCGAG	0.622000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				30	82					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70933493	70933493	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:70933493C>T	ENST00000264436.3	-	3	492	c.48G>A	c.(46-48)caG>caA	p.Q16Q	ADD2_ENST00000413157.2_Silent_p.Q16Q|ADD2_ENST00000407644.2_Silent_p.Q16Q|ADD2_ENST00000355733.3_Silent_p.Q16Q|ADD2_ENST00000430656.1_Silent_p.Q32Q	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	16					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						AAGGCTGCCCCTGCGGGGGCG	0.642000													30	76					0	0	1	0	0
CNTFR	1271	broad.mit.edu	37	9	34552812	34552812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34552812G>A	ENST00000378980.3	-	8	1102	c.809C>T	c.(808-810)gCc>gTc	p.A270V	CNTFR_ENST00000351266.4_Missense_Mutation_p.A270V	NM_001207011.1|NM_147164.2	NP_001193940.1|NP_671693.1	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	270	Fibronectin type-III 2.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(4)|skin(1)	15	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		CCCGGCGTAGGCATCTGTGAT	0.622000													22	126					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7845399	7845399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:7845399C>T	ENST00000283147.6	+	2	850	c.691C>T	c.(691-693)Cgt>Tgt	p.R231C		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	231					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					GTTCTCCCCTCGTCAGCGACA	0.468000													33	105					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233372591	233372591	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:233372591C>T	ENST00000258229.8	-	9	2592	c.2358_splice	c.e9+1	p.R786_splice	PCNXL2_ENST00000430153.1_Splice_Site_p.R85_splice	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	786						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				ATGTACGTACCCGTGGGGTTT	0.507000													38	160					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169432901	169432901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:169432901G>A	ENST00000261509.6	+	2	457	c.246G>A	c.(244-246)aaG>aaA	p.K82K	PALLD_ENST00000333488.4_5'UTR|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Silent_p.K82K	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	82					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CTTCCCATAAGGAGACCAAAT	0.483000									Pancreatic Cancer, Familial Clustering of				8	36					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51673920	51673920	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:51673920C>T	ENST00000409535.1	+	13	2261	c.2136C>T	c.(2134-2136)taC>taT	p.Y712Y	RAD54L2_ENST00000296477.3_Silent_p.Y406Y	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	712						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TGACTAATTACCAGACTGGAG	0.458000													8	24					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76757169	76757169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:76757169C>T	ENST00000536229.3	+	3	3844	c.3135C>T	c.(3133-3135)ctC>ctT	p.L1045L	SALL3_ENST00000575389.2_Silent_p.L1178L|SALL3_ENST00000537592.2_Silent_p.L1250L			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCAGCGCCCTCCCCCCTCTGG	0.622000													54	150					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6087196	6087196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:6087196C>T	ENST00000409021.3	-	4	1234	c.785G>A	c.(784-786)aGa>aAa	p.R262K	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.R97K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.R262K|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.R97K|JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.R262K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	262	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CGGGAGCTCTCTCTTTGGACT	0.627000													19	62					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080214	29080214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29080214G>A	ENST00000377169.1	+	1	547	c.547G>A	c.(547-549)Gaa>Aaa	p.E183K		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						CTTTTTCTGTGAAGTTCCAGC	0.463000													35	92					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59610056	59610056	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:59610056C>T	ENST00000541311.1	-	4	530	c.295_splice	c.e4-1	p.S99_splice	GIF_ENST00000257248.2_Splice_Site_p.S124_splice			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	124					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						AGCGTTGGGGCCTCCGAAGGG	0.517000													22	46					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24909430	24909430	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:24909430G>A	ENST00000347898.3	+	10	1628	c.1006_splice	c.e10+1	p.D336_splice	SLC5A11_ENST00000569071.1_Splice_Site_p.R203_splice|SLC5A11_ENST00000545376.1_Splice_Site_p.D266_splice|SLC5A11_ENST00000565769.1_Splice_Site_p.D272_splice|SLC5A11_ENST00000449109.2_Splice_Site_p.R203_splice|SLC5A11_ENST00000539472.1_Splice_Site_p.D272_splice|SLC5A11_ENST00000424767.2_Splice_Site_p.D301_splice|SLC5A11_ENST00000568579.1_Splice_Site_p.D266_splice|SLC5A11_ENST00000567758.1_Splice_Site_p.D301_splice	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	336					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		CCTCTTCCCAGGTGAGAACAC	0.493000													6	65					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450876	105450876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:105450876C>T	ENST00000337685.2	+	5	2236	c.1451C>T	c.(1450-1452)tCt>tTt	p.S484F	MUM1L1_ENST00000357175.2_Missense_Mutation_p.S484F|MUM1L1_ENST00000372552.1_Missense_Mutation_p.S484F	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	484										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						GGTTGTGGTTCTTTCACGGGC	0.393000													14	26					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15115135	15115135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:15115135G>A	ENST00000378217.3	+	9	1051	c.864G>A	c.(862-864)ggG>ggA	p.G288G	OLAH_ENST00000485251.1_3'UTR|OLAH_ENST00000378228.3_Silent_p.G235G	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	235					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						AGCTTCCAGGGGGTCACTTTT	0.343000													20	43					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576322	158576322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158576322C>T	ENST00000361284.1	+	1	94	c.94C>T	c.(94-96)Ctc>Ttc	p.L32F		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					TGCCTTGTTCCTCTCTCTGTA	0.502000													55	135					0	0	1	0	0
ZNF221	7638	broad.mit.edu	37	19	44470085	44470085	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:44470085C>T	ENST00000251269.5	+	6	759	c.431C>T	c.(430-432)tCt>tTt	p.S144F	ZNF221_ENST00000592350.1_Missense_Mutation_p.S144F|ZNF221_ENST00000587682.1_Missense_Mutation_p.S144F	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				AGGAACAGCTCTCAGTTCTTC	0.443000													27	110					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66434820	66434820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:66434820G>A	ENST00000341529.3	+	11	1886	c.1738G>A	c.(1738-1740)Gag>Aag	p.E580K	CDH5_ENST00000539168.1_Missense_Mutation_p.E19K	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	580	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CAAGTGCAACGAGCAGGGCGA	0.602000													17	69					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	326596	326596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:326596G>A	ENST00000264819.4	-	6	506	c.496C>T	c.(496-498)Cgt>Tgt	p.R166C		NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.R166C(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGGAAACGAGCTTTGGGA	0.562000													22	64					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164846	26164846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26164846C>T	ENST00000335473.7	+	4	1213	c.963C>T	c.(961-963)ttC>ttT	p.F321F	MYO18B_ENST00000536101.1_Silent_p.F321F|MYO18B_ENST00000407587.2_Silent_p.F321F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	321						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGGGAGGTTTCCTGGGAAGAA	0.532000													4	17					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22089606	22089606	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:22089606C>T	ENST00000261200.4	-	1	2	c.3G>A	c.(1-3)atG>atA	p.M1I	ABCC9_ENST00000261201.4_Start_Codon_SNP_p.M1I|ABCC9_ENST00000345162.2_Start_Codon_SNP_p.M1I|ABCC9_ENST00000326684.4_Start_Codon_SNP_p.M1I|ABCC9_ENST00000538350.1_Start_Codon_SNP_p.M1I	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATGAAAGGCTCATTTCTTCTT	0.333000													23	58					0	0	1	0	0
SPANXD	64648	broad.mit.edu	37	X	140785651	140785651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140785651C>T	ENST00000370515.3	-	2	598	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K		NM_032417.2|NM_145665.1	NP_115793.1|NP_663698.1			SPANX family, member D											breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	9	Acute lymphoblastic leukemia(192;7.65e-05)					ACCATTATTTCCATGAATTCC	0.433000													81	74					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177247750	177247750	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177247750C>T	ENST00000361539.4	+	7	1376	c.1064C>T	c.(1063-1065)tCc>tTc	p.S355F	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		355						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						TTCCTGAACTCCACAGCTATC	0.562000													71	236					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79267429	79267429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:79267429C>T	ENST00000428286.1	-	11	8650	c.7450G>A	c.(7450-7452)Gaa>Aaa	p.E2484K	PRUNE2_ENST00000443509.2_Missense_Mutation_p.E92K|PRUNE2_ENST00000466266.2_5'UTR|PRUNE2_ENST00000376718.3_Missense_Mutation_p.E2843K|PRUNE2_ENST00000223609.6_Missense_Mutation_p.E107K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2843					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GAATCTGCTTCATCGGGGGTA	0.393000													56	220					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284619	152284619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152284619C>T	ENST00000368799.1	-	3	2778	c.2743G>A	c.(2743-2745)Gaa>Aaa	p.E915K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	915	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAAGCTTCATGGTGACGT	0.567000									Ichthyosis				160	405					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141163850	141163850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141163850C>T	ENST00000514251.1	+	4	2899	c.2620C>T	c.(2620-2622)Cct>Tct	p.P874S	ZBTB38_ENST00000441582.2_Missense_Mutation_p.P874S|ZBTB38_ENST00000321464.5_Missense_Mutation_p.P875S			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	874					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						GCAGGAGGAGCCTTTGCCACA	0.478000													21	55					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103705025	103705025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:103705025G>A	ENST00000245312.3	-	3	1126	c.530C>T	c.(529-531)tCc>tTc	p.S177F		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	177					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CATTCCAATGGAAACAGGAAC	0.388000													25	67					0	0	1	0	0
P4HA3	283208	broad.mit.edu	37	11	74009390	74009390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:74009390C>T	ENST00000331597.4	-	4	629	c.584G>A	c.(583-585)gGg>gAg	p.G195E	P4HA3_ENST00000427714.2_Missense_Mutation_p.G195E	NM_182904.3	NP_878907.1	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha polypeptide III	195						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(1)	15	Breast(11;2.31e-05)					GTAATAATCCCCCATGTCATA	0.458000													46	115					0	0	1	0	0
SLC47A1	55244	broad.mit.edu	37	17	19470440	19470440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:19470440G>A	ENST00000270570.4	+	14	1294	c.1208G>A	c.(1207-1209)gGa>gAa	p.G403E	SLC47A1_ENST00000436810.2_Missense_Mutation_p.G380E|RP11-1113L8.1_ENST00000574267.1_RNA|SLC47A1_ENST00000571335.1_Missense_Mutation_p.G208E|SLC47A1_ENST00000575023.1_Intron|SLC47A1_ENST00000457293.1_Missense_Mutation_p.G403E|SLC47A1_ENST00000395585.1_Missense_Mutation_p.G403E	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	403						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					AGGGGGAGTGGAAATCAGAAG	0.542000													65	83					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58118620	58118620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:58118620G>A	ENST00000357272.4	+	26	4641	c.4476G>A	c.(4474-4476)atG>atA	p.M1492I	FLNB_ENST00000493452.1_Missense_Mutation_p.M1323I|FLNB_ENST00000490882.1_Missense_Mutation_p.M1523I|FLNB_ENST00000429972.2_Missense_Mutation_p.M1492I|FLNB_ENST00000419752.2_Missense_Mutation_p.M1323I|FLNB_ENST00000348383.5_Missense_Mutation_p.M1492I|FLNB_ENST00000295956.4_Missense_Mutation_p.M1492I|FLNB_ENST00000358537.3_Missense_Mutation_p.M1492I			O75369	FLNB_HUMAN	filamin B, beta	1492	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GACCTTACATGGTCTCAGTTA	0.512000													13	27					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668568	176668568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:176668568G>A	ENST00000367662.3	+	8	4243	c.3079G>A	c.(3079-3081)Gag>Aag	p.E1027K		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1027					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CACCTTTGATGAGAGGATAGA	0.562000													59	95					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91766302	91766302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91766302C>T	ENST00000389857.6	-	21	3834	c.3748G>A	c.(3748-3750)Gag>Aag	p.E1250K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1250					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTCTGGTTCTCGCCCATGGCG	0.652000													3	9					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29049290	29049290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29049290C>T	ENST00000257189.4	+	12	1958	c.1875C>T	c.(1873-1875)ctC>ctT	p.L625L		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	625					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCCTGCTGCTCCTTGGTCTCC	0.597000													29	68					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62599145	62599145	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:62599145C>T	ENST00000512091.1	+	7	1815	c.1068C>T	c.(1066-1068)ccC>ccT	p.P356P	LPHN3_ENST00000504896.1_Silent_p.P356P|LPHN3_ENST00000545650.1_Silent_p.P356P|LPHN3_ENST00000507164.1_Silent_p.P424P|LPHN3_ENST00000514157.1_Silent_p.P356P|LPHN3_ENST00000511324.1_Silent_p.P424P|LPHN3_ENST00000508693.1_Silent_p.P424P|LPHN3_ENST00000506746.1_Silent_p.P424P|LPHN3_ENST00000506700.1_Silent_p.P356P|LPHN3_ENST00000514591.1_Silent_p.P356P|LPHN3_ENST00000506720.1_Silent_p.P424P|LPHN3_ENST00000509896.1_Silent_p.P424P|LPHN3_ENST00000507625.1_Silent_p.P424P|LPHN3_ENST00000508946.1_Silent_p.P356P|LPHN3_ENST00000514996.1_Silent_p.P356P			Q9HAR2	LPHN3_HUMAN	latrophilin 3	356	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TGGATGTACCCTTTCCTAATT	0.388000													7	36					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080233	29080233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29080233G>A	ENST00000377169.1	+	1	566	c.566G>A	c.(565-567)cGa>cAa	p.R189Q		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						GCACTTCTGCGATTATCGTGT	0.448000													24	72					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104170845	104170845	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:104170845G>A	ENST00000020673.5	-	9	2497	c.1971C>T	c.(1969-1971)ctC>ctT	p.L657L	PSD_ENST00000406432.1_Silent_p.L657L	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	657	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TGAGCAGCATGAGCGCACAGG	0.647000													14	73					0	0	1	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435776	5435776	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5435776G>A	ENST00000380419.3	-	4	1082	c.1045C>T	c.(1045-1047)Cag>Tag	p.Q349*	TUBAL3_ENST00000479328.1_Nonsense_Mutation_p.Q309*	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	349					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						TCTACAAACTGAACAGAGTGC	0.567000													23	40					0	0	1	0	0
CCL28	56477	broad.mit.edu	37	5	43412406	43412406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:43412406C>T	ENST00000361115.4	-	1	87	c.13G>A	c.(13-15)Gga>Aga	p.G5R	CCL28_ENST00000537013.1_Missense_Mutation_p.G5R	NM_148672.2	NP_683513.1	Q9NRJ3	CCL28_HUMAN	chemokine (C-C motif) ligand 28	5					chemotaxis|immune response	extracellular space	chemokine activity			kidney(3)|lung(3)|ovary(1)	7						ATGGCGAGTCCTCTCTGCTGC	0.572000													7	40					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25887578	25887578	+	Missense_Mutation	SNP	C	C	T	rs151132862		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25887578C>T	ENST00000376351.3	+	11	3382	c.3023C>T	c.(3022-3024)cCt>cTt	p.P1008L	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1008						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GAGGTGTGTCCTTGGGAGGTT	0.478000													33	56					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333092	70333092	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:70333092G>T	ENST00000338508.4	-	32	3308	c.3309C>A	c.(3307-3309)ttC>ttA	p.F1103L	SHANK2_ENST00000423696.2_Missense_Mutation_p.F723L|SHANK2_ENST00000409161.1_Missense_Mutation_p.F506L|SHANK2_ENST00000449833.2_Missense_Mutation_p.F507L			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	723					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTGTGGAGAGGAAGGCCGGGG	0.692000													19	42					4.96729e-08	4.98266e-08	1	1	0
COL27A1	85301	broad.mit.edu	37	9	116930445	116930445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:116930445C>T	ENST00000356083.3	+	3	1001	c.610C>T	c.(610-612)Ccg>Tcg	p.P204S		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	204	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						GAAGATGAACCCGCATGCAGT	0.602000													20	50					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	99999541	99999541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:99999541C>T	ENST00000398027.2	-	17	1842	c.1595G>A	c.(1594-1596)gGc>gAc	p.G532D	ZCWPW1_ENST00000324725.6_Intron|ZCWPW1_ENST00000360951.4_Intron|ZCWPW1_ENST00000490721.1_Intron	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	532							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATTCCCTTGGCCTTCTTTCCT	0.527000													38	93					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128595288	128595288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:128595288C>T	ENST00000335251.5	+	6	1204	c.1101C>T	c.(1099-1101)ctC>ctT	p.L367L	INTU_ENST00000296461.5_Silent_p.L367L	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	367										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						GTTCATCCCTCCTTTTAAATG	0.303000													11	49					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584886	30584886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30584886C>T	ENST00000217299.3	+	3	1540	c.1366C>T	c.(1366-1368)Cgt>Tgt	p.R456C		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	456						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TTGCATCTTCCGTAAGGCCTC	0.632000													42	84					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545280	186545280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186545280G>A	ENST00000431808.1	-	14	1854	c.1291C>T	c.(1291-1293)Cgc>Tgc	p.R431C	SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.R531C|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.R335C|SORBS2_ENST00000284776.7_Missense_Mutation_p.R431C			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	431						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.R431C(1)		endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CCGTTACTGCGAACCTCCGGG	0.592000													22	56					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53072390	53072390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53072390C>T	ENST00000252244.3	-	2	800	c.742G>A	c.(742-744)Gat>Aat	p.D248N		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	248	Coil 1B.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding	p.D248N(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CGAGATTGATCACTCTTCAGT	0.473000													26	105					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140737029	140737029	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140737029C>T	ENST00000571252.1	+	1	2262	c.2262C>T	c.(2260-2262)tcC>tcT	p.S754S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACCTATTCCCACGAGGTCT	0.602000													27	123					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4649113	4649113	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4649113G>A	ENST00000433935.1	+	14	2114		c.e14-1		ZMYND15_ENST00000573751.2_Splice_Site|ZMYND15_ENST00000269289.6_Splice_Site|ZMYND15_ENST00000592813.1_Splice_Site	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15								zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						CGCCCCCGCAGGTACTGCAAT	0.741000													8	11					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6128044	6128044	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6128044A>G	ENST00000261405.5	-	28	4794	c.4540T>C	c.(4540-4542)Ttc>Ctc	p.F1514L		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1514	VWFA 2.		F -> C (in VWD2).		blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CTCCTGTTGAAGTCGGCTTCA	0.572000													7	41					0	0	1	0	0
PIGT	51604	broad.mit.edu	37	20	44050117	44050117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:44050117C>T	ENST00000279036.6	+	9	1208	c.1128C>T	c.(1126-1128)caC>caT	p.H376H	PIGT_ENST00000279035.9_Silent_p.H274H|PIGT_ENST00000545755.1_Silent_p.H114H|PIGT_ENST00000341555.5_Silent_p.H182H|PIGT_ENST00000543458.2_Silent_p.H320H|PIGT_ENST00000372689.5_Intron|PIGT_ENST00000535404.1_Silent_p.H221H	NM_015937.5	NP_057021.2	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class T	376					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(1)|endometrium(2)|kidney(5)|large_intestine(4)|lung(7)|pancreas(1)|skin(1)|stomach(1)	22		Myeloproliferative disorder(115;0.0122)				ACAACACCCACCCATACCGGG	0.622000													13	79					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117299059	117299059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:117299059G>A	ENST00000321322.6	-	33	6328	c.6327C>T	c.(6325-6327)tcC>tcT	p.S2109S	DSCAML1_ENST00000527706.1_Silent_p.S1839S	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	2049					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCAGGGTGTAGGATTTGGAGT	0.627000													25	70					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91169121	91169121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:91169121C>T	ENST00000420329.2	+	10	1010	c.863C>T	c.(862-864)gCc>gTc	p.A288V	RP11-387D10.2_ENST00000559531.1_RNA|CRTC3_ENST00000268184.6_Missense_Mutation_p.A288V	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	288					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CCCCTGCCAGCCTCCCTGGAC	0.542000			T	MAML2	salivary gland mucoepidermoid								71	531					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27997756	27997756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:27997756C>T	ENST00000441525.1	-	1	1810	c.1696G>A	c.(1696-1698)Gat>Aat	p.D566N		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	566								p.D566N(1)		NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						GCTCCATGATCTCTCCAGCCG	0.512000													12	69					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18149669	18149669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:18149669G>A	ENST00000375406.1	+	2	382	c.166G>A	c.(166-168)Gac>Aac	p.D56N		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	56						cytoplasm|cytoskeleton		p.D56Y(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CCTGGGCATCGACATTTGCCA	0.572000													56	106					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141952422	141952422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:141952422G>A	ENST00000552471.1	-	4	765	c.446C>T	c.(445-447)cCc>cTc	p.P149L	PRSS58_ENST00000547058.2_Missense_Mutation_p.P149L			Q8IYP2	PRS58_HUMAN	protease, serine, 58	149	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						CAGTGAATCGGGCTCTTTGTC	0.373000													35	87					0	0	1	0	0
ATP6V1G3	127124	broad.mit.edu	37	1	198492560	198492560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:198492560C>T	ENST00000367381.1	-	5	441	c.336G>A	c.(334-336)atG>atA	p.M112I	ATP6V1G3_ENST00000281087.2_Missense_Mutation_p.M106I|ATP6V1G3_ENST00000309309.7_3'UTR|ATP6V1G3_ENST00000367382.1_Missense_Mutation_p.M106I|ATP6V1G3_ENST00000489986.1_Missense_Mutation_p.M112I			Q96LB4	VATG3_HUMAN	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	106					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	7						TTTCTGGTTTCATGTCACAGA	0.398000													8	30					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50757272	50757272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:50757272G>A	ENST00000300589.2	+	9	2964	c.2859G>A	c.(2857-2859)aaG>aaA	p.K953K		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	953					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TGCTGGCAAAGAACGTCATGC	0.527000													8	33					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129231625	129231625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:129231625C>T	ENST00000280333.6	+	48	5039	c.4930C>T	c.(4930-4932)Cct>Tct	p.P1644S		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1644					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CTCATCCCGCCCTCTGTCTGT	0.612000													55	91					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89346952	89346952	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89346952G>A	ENST00000301030.4	-	9	6458	c.5998C>T	c.(5998-6000)Ctc>Ttc	p.L2000F	ANKRD11_ENST00000378330.2_Missense_Mutation_p.L2000F	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2000	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCAGAGTGGAGGGGGTCCGCG	0.701000													11	30					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56349081	56349081	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:56349081G>T	ENST00000340482.3	-	10	2237	c.2061C>A	c.(2059-2061)ggC>ggA	p.G687G	MPO_ENST00000225275.3_Silent_p.G655G			P05164	PERM_HUMAN	myeloperoxidase	655					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GGCCCACGCGGCCTTTGCGCT	0.632000													14	34					8.60227e-14	8.64612e-14	1	1	0
KCNQ3	3786	broad.mit.edu	37	8	133152366	133152366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133152366C>T	ENST00000388996.4	-	11	1945	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	KCNQ3_ENST00000519445.1_Missense_Mutation_p.E509K|KCNQ3_ENST00000521134.1_Missense_Mutation_p.E389K	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	509					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ATCATGTCTTCGATGGGGAAG	0.627000													17	57					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231249970	231249970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231249970G>A	ENST00000243810.6	+	9	735	c.735G>A	c.(733-735)tcG>tcA	p.S245S	SP140L_ENST00000415673.2_Silent_p.S245S|SP140L_ENST00000444636.1_Silent_p.S245S|SP140L_ENST00000396563.4_Silent_p.S245S			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	245						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						AGCTGGTCTCGAGTGAAAAGA	0.458000													12	84					0	0	1	0	0
CORO1A	11151	broad.mit.edu	37	16	30199825	30199825	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30199825G>A	ENST00000219150.5	+	10	1514	c.1209G>A	c.(1207-1209)gaG>gaA	p.E403E	CORO1A_ENST00000570045.1_Silent_p.E403E|CORO1A_ENST00000565497.1_Intron	NM_001193333.2|NM_007074.3	NP_001180262.1|NP_009005.1	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	403					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	9						AGAGCCGGGAGCTGAGGGTCA	0.682000													20	38					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2933011	2933011	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:2933011G>A	ENST00000381130.2	+	4	341	c.340_splice	c.e4-1	p.G114_splice		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	114						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TTACTTTTAGGCAAATGGCAC	0.453000													5	11					0	0	1	0	0
NOP2	4839	broad.mit.edu	37	12	6670901	6670901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6670901G>A	ENST00000541778.1	-	11	1612	c.1124C>T	c.(1123-1125)gCc>gTc	p.A375V	NOP2_ENST00000322166.5_Missense_Mutation_p.A379V|NOP2_ENST00000382421.3_Missense_Mutation_p.A412V|NOP2_ENST00000537442.1_Missense_Mutation_p.A379V|NOP2_ENST00000545200.1_Missense_Mutation_p.A375V|NOP2_ENST00000399466.2_Missense_Mutation_p.A375V|NOP2_ENST00000542015.1_Intron			P46087	NOP2_HUMAN	NOP2 nucleolar protein	379					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	19						GGGTGCCAAGGCCATGACGGG	0.607000													4	22					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135866329	135866329	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135866329C>T	ENST00000339463.3	+	11	1704	c.885C>T	c.(883-885)agC>agT	p.S295S	GFI1B_ENST00000372122.1_Silent_p.S295S|GFI1B_ENST00000534944.1_Silent_p.S249S|GFI1B_ENST00000450530.1_Silent_p.S295S|GFI1B_ENST00000372124.1_Silent_p.S249S|GFI1B_ENST00000372123.1_Silent_p.S249S			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	295	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		TCACCCACAGCCGCAAGCACA	0.632000													13	52					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	65968957	65968957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:65968957G>A	ENST00000443035.3	-	24	4407	c.4192C>T	c.(4192-4194)Cgt>Tgt	p.R1398C	DENND4A_ENST00000431932.2_Missense_Mutation_p.R1355C	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	1355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						AGACTGGTACGATCAGAACTT	0.363000													8	29					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76572088	76572088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:76572088C>T	ENST00000307431.8	+	20	3453	c.3068C>T	c.(3067-3069)tCc>tTc	p.S1023F	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.S951F|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.S975F|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.S1027F|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1024					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AGTAAAAACTCCAGCTCCCAC	0.333000													10	46					0	0	1	0	0
LINC00696	100128378	broad.mit.edu	37	3	52097298	52097298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52097298C>T	ENST00000541313.1	-	1	269	c.270G>A	c.(268-270)acG>acA	p.T90T																								ACAGAACATTCGTGCTACCAA	0.542000													87	180					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204926948	204926948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:204926948C>T	ENST00000367172.4	+	8	1028	c.700C>T	c.(700-702)Ctc>Ttc	p.L234F	NFASC_ENST00000513543.1_Missense_Mutation_p.L228F|NFASC_ENST00000338586.6_Missense_Mutation_p.L234F|NFASC_ENST00000367169.4_Missense_Mutation_p.L234F|NFASC_ENST00000360049.4_Missense_Mutation_p.L228F|NFASC_ENST00000367171.4_Missense_Mutation_p.L234F|NFASC_ENST00000401399.1_Missense_Mutation_p.L234F|NFASC_ENST00000539706.1_Missense_Mutation_p.L228F|NFASC_ENST00000403080.1_Missense_Mutation_p.L234F|NFASC_ENST00000367170.4_Missense_Mutation_p.L234F|NFASC_ENST00000339876.6_Missense_Mutation_p.L234F|NFASC_ENST00000404907.1_Missense_Mutation_p.L228F|NFASC_ENST00000404076.1_Missense_Mutation_p.L228F|NFASC_ENST00000338515.6_Missense_Mutation_p.L234F			O94856	NFASC_HUMAN	neurofascin	234					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCTCAAGGTCCTCACCAGTAA	0.577000													39	82					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106917020	106917020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:106917020G>A	ENST00000369701.3	+	10	1834	c.1607G>A	c.(1606-1608)gGa>gAa	p.G536E		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	536						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GACCTGAGAGGAAGCCCAGTG	0.567000													8	43					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997368	115997368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:115997368C>T	ENST00000264363.2	-	2	1503	c.825G>A	c.(823-825)ttG>ttA	p.L275L		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	275	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GCCAAAAGTTCAAGTTGTTGC	0.453000													56	148					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70514339	70514339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:70514339C>T	ENST00000377844.4	-	4	1606	c.847G>A	c.(847-849)Gag>Aag	p.E283K	KLHL1_ENST00000545028.1_Missense_Mutation_p.E90K	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	283					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AGAAGGTTCTCAATGGTGTCC	0.393000													13	27					0	0	1	0	0
CHRNA6	8973	broad.mit.edu	37	8	42611578	42611578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:42611578G>A	ENST00000276410.2	-	5	1119	c.764C>T	c.(763-765)tCa>tTa	p.S255L	CHRNA6_ENST00000534622.1_Missense_Mutation_p.S240L	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	255						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GGTTAGAAATGAAATAAAGAG	0.378000													7	63					0	0	1	0	0
APCDD1L	164284	broad.mit.edu	37	20	57035978	57035978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:57035978C>T	ENST00000371149.3	-	4	1604	c.1374G>A	c.(1372-1374)gaG>gaA	p.E458E	APCDD1L_ENST00000439429.1_Silent_p.E469E	NM_153360.1	NP_699191.1	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated 1-like	458						integral to membrane				large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(1)	18	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			AGTCGGGGGCCTCCCCATGAC	0.627000													28	74					0	0	1	0	0
LBP	3929	broad.mit.edu	37	20	36993269	36993269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:36993269C>T	ENST00000217407.2	+	8	945	c.784C>T	c.(784-786)Ctc>Ttc	p.L262F		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	262					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				TCCAGTTACCCTCCTTGCTGC	0.493000													61	145					0	0	1	0	0
TRABD2A	129293	broad.mit.edu	37	2	85051079	85051079	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:85051079C>T	ENST00000335459.5	-	5	1390	c.1185G>A	c.(1183-1185)gaG>gaA	p.E395E	TRABD2A_ENST00000479944.1_5'UTR|TRABD2A_ENST00000409520.2_Silent_p.E444E	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		CGCCTGACCTCTCCTCCAGGC	0.647000													9	24					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905626	15905626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15905626C>T	ENST00000308940.8	+	1	866	c.768C>T	c.(766-768)gcC>gcT	p.A256A		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						ATGGCTTTGCCTCCGTCATTT	0.572000													18	50					0	0	1	0	0
PRR11	55771	broad.mit.edu	37	17	57270872	57270872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:57270872C>T	ENST00000262293.4	+	5	734	c.422C>T	c.(421-423)tCc>tTc	p.S141F		NM_018304.3	NP_060774.2	Q96HE9	PRR11_HUMAN	proline rich 11	141										breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|pancreas(1)	16	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GAAAGTTCTTCCTGTCCAAGC	0.418000													17	87					0	0	1	0	0
LCN1	3933	broad.mit.edu	37	9	138415806	138415806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:138415806G>A	ENST00000263598.2	+	4	433	c.373G>A	c.(373-375)Ggg>Agg	p.G125R	LCN1_ENST00000371781.3_Missense_Mutation_p.G125R	NM_001252617.1|NM_001252618.1|NM_001252619.1|NM_002297.3	NP_001239546.1|NP_001239547.1|NP_001239548.1|NP_002288.1	P31025	LCN1_HUMAN	lipocalin 1	125					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)	13		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		CGAGCTGCACGGGAAGCCGGT	0.637000													11	42					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112357	248112357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:248112357C>T	ENST00000357191.3	+	1	198	c.198C>T	c.(196-198)tcC>tcT	p.S66S	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTCAGCTCTCCCTCATTGACC	0.438000													129	391					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634495	156634495	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156634495G>A	ENST00000296518.7	+	7	1541	c.1332G>A	c.(1330-1332)gaG>gaA	p.E444E	GUCY1A3_ENST00000393832.3_Silent_p.E186E|GUCY1A3_ENST00000511507.1_Silent_p.E444E|GUCY1A3_ENST00000506455.1_Silent_p.E444E|GUCY1A3_ENST00000513574.1_Silent_p.E444E|GUCY1A3_ENST00000511108.1_Silent_p.E444E|GUCY1A3_ENST00000455639.2_Silent_p.E444E			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	444					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		AAGCCCTGGAGGAGGAGAAGA	0.527000													26	75					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31608409	31608409	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:31608409G>A	ENST00000331728.4	+	1	129	c.16_splice	c.e1+1	p.A5_splice	LIMK2_ENST00000406516.1_5'UTR|LIMK2_ENST00000444929.2_Splice_Site_p.A5_splice	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	5						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						CCGCGCTGGCGGGTAAGGAAG	0.672000													14	22					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240611	3240611	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:3240611C>T	ENST00000217939.6	-	5	3269	c.3115G>A	c.(3115-3117)Gac>Aac	p.D1039N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1039						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGGATGTTGTCTGTCAGTCCT	0.428000													68	38					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	666022	666022	+	Silent	SNP	C	C	T	rs150365241		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:666022C>T	ENST00000266383.5	+	15	2383	c.2370C>T	c.(2368-2370)ttC>ttT	p.F790F		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	790						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	p.F790F(1)		breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TGGTCCACTTCGTCGTGCCTG	0.607000													7	33					0	0	1	0	0
FEZ2	9637	broad.mit.edu	37	2	36782889	36782889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:36782889G>A	ENST00000379245.4	-	8	1111	c.1063C>T	c.(1063-1065)Ctt>Ttt	p.L355F	FEZ2_ENST00000305852.7_Missense_Mutation_p.L157F|FEZ2_ENST00000487919.1_5'UTR|FEZ2_ENST00000405912.3_Missense_Mutation_p.L328F	NM_001042548.1	NP_001036013.1	Q9UHY8	FEZ2_HUMAN	fasciculation and elongation protein zeta 2 (zygin II)	328					axon guidance|signal transduction		protein binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	7		all_hematologic(82;0.21)				ATGGCACGAAGAACTGCAAAA	0.333000													11	32					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52554926	52554926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:52554926G>A	ENST00000321725.6	+	55	5889	c.5813G>A	c.(5812-5814)aGg>aAg	p.R1938K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1938					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTTTGGGGTAGGCCCCAAGGC	0.642000													16	72					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158608031	158608031	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158608031C>T	ENST00000368148.3	-	36	5161	c.4980_splice	c.e36-1	p.D1661_splice	SPTA1_ENST00000368147.3_Splice_Site_p.D1661_splice	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1661					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTGAGTGCATCCTAGAAAGTC	0.433000													8	22					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207110583	207110583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207110583G>A	ENST00000356495.4	-	4	1085	c.902C>T	c.(901-903)cCc>cTc	p.P301L		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	301	Ig-like V-type 3.					extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTTGTCCTGGGGGTTGAGCAG	0.587000													27	50					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94944769	94944769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:94944769G>A	ENST00000222381.3	-	4	466	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	PON1_ENST00000542556.1_Missense_Mutation_p.P79S	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	79					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GGACTGTTGGGGTTGAAGCTC	0.393000													16	71					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25885707	25885707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25885707G>A	ENST00000376351.3	+	10	2493	c.2134G>A	c.(2134-2136)Gag>Aag	p.E712K	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	712						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CTTGGATCCAGAGGACATTCG	0.488000													20	72					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577764	9577764	+	Missense_Mutation	SNP	C	C	T	rs139799240	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9577764C>T	ENST00000301480.4	-	10	2072	c.1859G>A	c.(1858-1860)cGa>cAa	p.R620Q		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	620					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						AGTGTGTCTTCGTAAATGTTT	0.393000													46	119					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130488626	130488626	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:130488626T>G	ENST00000373289.3	+	10	1448	c.1368T>G	c.(1366-1368)atT>atG	p.I456M	TTC16_ENST00000489226.1_3'UTR	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	456							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						TGCAGAACATTTTTGGGGCCC	0.607000													6	60					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27941044	27941044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:27941044G>A	ENST00000374005.3	-	11	1434	c.1146C>T	c.(1144-1146)gaC>gaT	p.D382D	FGR_ENST00000399173.1_Silent_p.D382D|FGR_ENST00000374004.1_Silent_p.D382D|FGR_ENST00000545953.1_Silent_p.D316D	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	382	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CTGCCCTCAGGTCGCGGTGAA	0.582000													10	25					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50610686	50610686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:50610686G>A	ENST00000371824.1	+	2	324	c.67G>A	c.(67-69)Gga>Aga	p.G23R	ELAVL4_ENST00000357083.4_Missense_Mutation_p.G40R|ELAVL4_ENST00000492299.1_3'UTR|ELAVL4_ENST00000371823.4_Missense_Mutation_p.G23R|ELAVL4_ENST00000371821.1_Missense_Mutation_p.G28R|ELAVL4_ENST00000448907.2_Missense_Mutation_p.G26R|ELAVL4_ENST00000371819.1_Missense_Mutation_p.G28R|ELAVL4_ENST00000371827.1_Missense_Mutation_p.G23R			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	23					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						TACAAGCAATGGACCCTCCAG	0.418000													7	54					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86894926	86894926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:86894926C>T	ENST00000376238.4	-	16	1841	c.1792G>A	c.(1792-1794)Ggg>Agg	p.G598R	SLC28A3_ENST00000537648.1_Missense_Mutation_p.G529R|RP11-380F14.2_ENST00000419815.1_RNA	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	598					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GCCACGGTCCCCGCAATCAGA	0.572000													6	28					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746607	77746607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:77746607G>A	ENST00000409088.3	-	3	802	c.388C>T	c.(388-390)Cac>Tac	p.H130Y	LRRTM4_ENST00000409884.1_Missense_Mutation_p.H130Y|LRRTM4_ENST00000409911.1_Missense_Mutation_p.H131Y|LRRTM4_ENST00000409093.1_Missense_Mutation_p.H130Y|LRRTM4_ENST00000409282.1_Missense_Mutation_p.H131Y	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	130						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		GGAACTGGGTGAAATGTTTTA	0.388000													36	44					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53607910	53607910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53607910G>A	ENST00000425354.2	-	7	1233	c.746C>T	c.(745-747)cCt>cTt	p.P249L	RARG_ENST00000327550.3_Missense_Mutation_p.P177L|RARG_ENST00000543762.1_5'UTR|RARG_ENST00000338561.5_Missense_Mutation_p.P238L|RARG_ENST00000394426.1_Missense_Mutation_p.P249L|RARG_ENST00000543726.1_Missense_Mutation_p.P227L	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	249	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TGTAAAGCCAGGCAACCGCTT	0.572000											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	159					0	0	1	0	0
PIAS1	8554	broad.mit.edu	37	15	68445979	68445979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68445979C>T	ENST00000545237.1	+	8	1627	c.886C>T	c.(886-888)Ctt>Ttt	p.L296F	PIAS1_ENST00000249636.6_Missense_Mutation_p.L294F			O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	294					androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)	24						AACAGTTCTTCTTCAGAGGTT	0.323000													29	41					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	31066223	31066223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:31066223G>A	ENST00000399914.1	-	2	799	c.278C>T	c.(277-279)tCg>tTg	p.S93L	GRIK1_ENST00000399907.1_Missense_Mutation_p.S93L|GRIK1_ENST00000399913.1_Missense_Mutation_p.S93L|GRIK1_ENST00000389125.3_Missense_Mutation_p.S93L|GRIK1_ENST00000399909.1_Missense_Mutation_p.S93L|GRIK1_ENST00000327783.4_Missense_Mutation_p.S93L|GRIK1_ENST00000535441.1_Missense_Mutation_p.S93L|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000389124.2_Missense_Mutation_p.S93L|GRIK1_ENST00000309434.7_Missense_Mutation_p.S93L			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	93					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	ACCTCTCCGCGAGGCTTCAAA	0.423000													46	100					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743007	26743007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:26743007G>A	ENST00000396005.3	-	1	564	c.255C>T	c.(253-255)ttC>ttT	p.F85F	SLC5A12_ENST00000280467.6_Silent_p.F85F	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	85					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GGTAAGCAATGAAGAAGACTA	0.488000													22	70					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124392769	124392769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124392769C>T	ENST00000338354.3	+	49	6179	c.6073C>T	c.(6073-6075)Ccc>Tcc	p.P2025S	DMBT1_ENST00000344338.3_Missense_Mutation_p.P2015S|DMBT1_ENST00000368955.3_Missense_Mutation_p.P2015S|DMBT1_ENST00000359586.6_Missense_Mutation_p.P745S|DMBT1_ENST00000330163.4_Missense_Mutation_p.P1397S|DMBT1_ENST00000368956.2_Missense_Mutation_p.P1397S|DMBT1_ENST00000368909.3_Missense_Mutation_p.P2025S			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2025	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCCATTCTATCCCGGGAACTA	0.507000													32	93					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750162	140750162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140750162G>A	ENST00000576222.1	+	1	332	c.201G>A	c.(199-201)cgG>cgA	p.R67R	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAACCTGCGGGTTATTGCAG	0.542000													18	195					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35619167	35619167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:35619167G>A	ENST00000400445.3	+	3	1144	c.610G>A	c.(610-612)Gga>Aga	p.G204R	NBEA_ENST00000310336.4_Missense_Mutation_p.G204R|NBEA_ENST00000540320.1_Missense_Mutation_p.G204R|NBEA_ENST00000379939.2_Missense_Mutation_p.G204R	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	204						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CATGCTTCGAGGAGAAAGTGG	0.403000													6	21					0	0	1	0	0
ODAM	54959	broad.mit.edu	37	4	71063012	71063012	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71063012G>A	ENST00000396094.2	+	3	163	c.115G>A	c.(115-117)Ggt>Agt	p.G39S		NM_017855.3	NP_060325.3	A1E959	ODAM_HUMAN	odontogenic, ameloblast asssociated	39					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(3)|skin(2)	20						TCTTAATAATGGTCAACTTTT	0.279000													23	87					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123298188	123298188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:123298188G>A	ENST00000358487.5	-	6	938	c.666C>T	c.(664-666)gtC>gtT	p.V222V	FGFR2_ENST00000359354.2_Silent_p.V222V|FGFR2_ENST00000360144.3_Silent_p.V133V|FGFR2_ENST00000369059.1_Silent_p.V107V|FGFR2_ENST00000351936.6_Silent_p.V222V|FGFR2_ENST00000357555.5_Silent_p.V133V|FGFR2_ENST00000369060.4_Silent_p.V222V|FGFR2_ENST00000346997.2_Silent_p.V222V|FGFR2_ENST00000356226.4_Silent_p.V107V|FGFR2_ENST00000457416.2_Silent_p.V222V|FGFR2_ENST00000369061.4_Silent_p.V222V|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000369056.1_Silent_p.V222V	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	222	Ig-like C2-type 2.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TGTCAGATGGGACCACACTTT	0.453000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				10	93					0	0	1	0	0
LRRC3	81543	broad.mit.edu	37	21	45877172	45877172	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:45877172C>T	ENST00000291592.4	+	2	962	c.645C>T	c.(643-645)ttC>ttT	p.F215F		NM_030891.3	NP_112153.1	Q9BY71	LRRC3_HUMAN	leucine rich repeat containing 3	215						integral to membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		TCGGCTGGTTCGCCATGGTGA	0.642000													8	82					0	0	1	0	0
HGSNAT	138050	broad.mit.edu	37	8	43054643	43054643	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:43054643C>T	ENST00000458501.2	+	18	1923	c.1923C>T	c.(1921-1923)atC>atT	p.I641I	HGSNAT_ENST00000379644.4_Silent_p.I613I|HGSNAT_ENST00000521576.1_Silent_p.I330I|HGSNAT_ENST00000297798.7_Silent_p.I345I			Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	641					lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(6)	13	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			CTCAGAACATCGTCGCCACTG	0.498000													8	22					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13720097	13720097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:13720097C>T	ENST00000279593.3	-	12	2669	c.2460G>A	c.(2458-2460)ggG>ggA	p.G820G		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	820					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTAGAAGACCCCTGCCATGT	0.512000													20	74					0	0	1	0	0
VDR	7421	broad.mit.edu	37	12	48240510	48240510	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48240510G>A	ENST00000229022.3	-	9	1118	c.837C>T	c.(835-837)ttC>ttT	p.F279F	VDR_ENST00000549336.1_Silent_p.F279F|VDR_ENST00000550325.1_Silent_p.F329F|VDR_ENST00000395324.2_Silent_p.F279F|VDR_ENST00000535672.1_Silent_p.F247F	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	279	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CGTCCATGGTGAAGGACTCAT	0.552000													27	64					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31712394	31712394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:31712394G>A	ENST00000396556.2	-	9	1930	c.1808C>T	c.(1807-1809)cCg>cTg	p.P603L	OSBPL10_ENST00000438237.2_Missense_Mutation_p.P539L	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	603					lipid transport		lipid binding	p.P603L(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		CTCCACCCACGGGATGGTGAG	0.567000													7	86					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42728211	42728211	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:42728211C>T	ENST00000287777.4	+	1	1201	c.1101C>T	c.(1099-1101)ctC>ctT	p.L367L		NM_152393.2	NP_689606.2			kelch-like family member 40																		CTGGAGGCCTCTTCTACAACG	0.582000													7	47					0	0	1	0	0
CACNG8	59283	broad.mit.edu	37	19	54466657	54466657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54466657C>T	ENST00000270458.2	+	1	364	c.261C>T	c.(259-261)ctC>ctT	p.L87L		NM_031895.5	NP_114101.4	Q8WXS5	CCG8_HUMAN	calcium channel, voltage-dependent, gamma subunit 8	87					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			kidney(1)|large_intestine(3)|lung(8)|urinary_tract(1)	13	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		ACTCGGGCCTCTGGAGGATCT	0.771000													4	15					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44974582	44974582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:44974582C>T	ENST00000340446.4	-	1	1900	c.1609G>A	c.(1609-1611)Gaa>Aaa	p.E537K		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	537	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		GCAGGAGTTTCATCTGCAGGA	0.488000													20	29					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43496117	43496117	+	Translation_Start_Site	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:43496117A>T	ENST00000400427.1	+	0	260				UMODL1_ENST00000408989.2_Missense_Mutation_p.K27I|UMODL1_ENST00000400424.1_De_novo_Start_OutOfFrame|UMODL1_ENST00000408910.2_Missense_Mutation_p.K27I	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1							cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CTTTCAGAAAAAGGCCTCTCC	0.567000													74	155					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66462294	66462294	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:66462294G>A	ENST00000404260.3	+	29	7604	c.7296G>A	c.(7294-7296)acG>acA	p.T2432T	MAST4_ENST00000403625.2_Silent_p.T2429T|MAST4_ENST00000405643.1_Silent_p.T2250T|MAST4_ENST00000403666.1_Silent_p.T2240T|MAST4_ENST00000261569.7_Silent_p.T2235T			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	2432						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGCCACCGACGGAGGCAGACA	0.662000											OREG0016638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	8					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176476	140176476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140176476C>T	ENST00000526136.1	+	1	1927	c.1927C>T	c.(1927-1929)Cct>Tct	p.P643S	PCDHA2_ENST00000378132.1_Missense_Mutation_p.P643S|PCDHA2_ENST00000520672.2_Missense_Mutation_p.P643S|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTGACTCCCCTCGACACCG	0.637000													29	66					0	0	1	0	0
WT1-AS	51352	broad.mit.edu	37	11	32460452	32460452	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:32460452G>A	ENST00000395900.1	+	0	1330				WT1-AS_ENST00000525436.1_RNA|WT1-AS_ENST00000426618.2_RNA|WT1-AS_ENST00000442957.1_RNA	NR_023920.1															endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6						ACAGCCCCTGGAAAACCATGT	0.537000													11	23					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47847945	47847945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:47847945G>A	ENST00000289672.2	-	52	7777	c.7727C>T	c.(7726-7728)tCc>tTc	p.S2576F	C7orf69_ENST00000418326.2_Intron|C7orf69_ENST00000258776.4_Intron	NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2576					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AAGGTGGCCGGAAACTGCATA	0.527000													15	44					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835376	38835376	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38835376C>T	ENST00000449082.2	-	1	125	c.126G>A	c.(124-126)agG>agA	p.R42R		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	42					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCTTCTGCTCCCTATGCTTCT	0.522000													57	143					0	0	1	0	0
ZNF555	148254	broad.mit.edu	37	19	2852691	2852691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2852691C>T	ENST00000334241.4	+	4	766	c.628C>T	c.(628-630)Cct>Tct	p.P210S	AC006130.3_ENST00000589365.1_RNA|ZNF555_ENST00000591539.1_Missense_Mutation_p.P209S	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAAACCTTTCCTCGTACTTC	0.448000													40	75					0	0	1	0	0
MS4A6E	245802	broad.mit.edu	37	11	60105304	60105304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60105304C>T	ENST00000300182.4	+	2	303	c.238C>T	c.(238-240)Cct>Tct	p.P80S		NM_139249.2	NP_640342.1	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member 6E	80						integral to membrane	receptor activity			endometrium(2)|kidney(1)|lung(9)|stomach(1)	13						TGCATTAAATCCTGCCTCATT	0.473000													34	115					0	0	1	0	0
TPD52L1	7164	broad.mit.edu	37	6	125574873	125574873	+	Missense_Mutation	SNP	C	C	T	rs34034771		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:125574873C>T	ENST00000534000.1	+	5	693	c.397C>T	c.(397-399)Cgc>Tgc	p.R133C	TPD52L1_ENST00000528193.1_Missense_Mutation_p.R133C|TPD52L1_ENST00000530868.1_3'UTR|TPD52L1_ENST00000534199.1_Intron|TPD52L1_ENST00000524679.1_Intron|TPD52L1_ENST00000304877.13_Missense_Mutation_p.R138C|TPD52L1_ENST00000392482.2_Intron|TPD52L1_ENST00000532429.1_Missense_Mutation_p.R104C|TPD52L1_ENST00000368402.5_Missense_Mutation_p.R133C|TPD52L1_ENST00000368388.2_Intron|TPD52L1_ENST00000527711.1_Intron	NM_003287.2	NP_003278.1	Q16890	TPD53_HUMAN	tumor protein D52-like 1	133					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|large_intestine(2)|prostate(1)	5			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		TTACTCCATTCGCCATTCCAT	0.299000													33	66					0	0	1	0	0
SPATA31C1	441452	broad.mit.edu	37	9	90535853	90535853	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:90535853C>T	ENST00000602681.1	+	0	1757																											CCCTTTATTTCATCCACACCC	0.567000													68	251					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15480430	15480430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:15480430G>A	ENST00000217246.4	+	8	978	c.583G>A	c.(583-585)Gag>Aag	p.E195K	MACROD2_ENST00000310348.4_Missense_Mutation_p.E195K|MACROD2_ENST00000402914.1_5'UTR	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	195	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CTTTCCCAACGAGCCTGCTGC	0.443000													22	54					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155287468	155287468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155287468G>A	ENST00000357232.3	-	5	587	c.588C>T	c.(586-588)atC>atT	p.I196I	DCHS2_ENST00000339452.1_Silent_p.I790I	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	196	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAACATTGATGATCTCGGTGC	0.483000													16	44					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34571961	34571961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34571961C>T	ENST00000373973.3	+	5	638	c.465C>T	c.(463-465)ttC>ttT	p.F155F	CNBD2_ENST00000349339.1_Silent_p.F155F|CNBD2_ENST00000538900.1_Silent_p.F155F					cyclic nucleotide binding domain containing 2																		GCTTTTATTTCATCTACCTGG	0.522000													22	65					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178418910	178418910	+	Missense_Mutation	SNP	C	C	T	rs17078901		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:178418910C>T	ENST00000231188.5	-	2	857	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	GRM6_ENST00000517717.1_Missense_Mutation_p.E227K	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	227			E -> V (in dbSNP:rs17078898).		detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		ACCCCACTTTCGCCATAGTTG	0.637000													11	28					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127613669	127613669	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:127613669G>A	ENST00000508053.1	-	64	8348	c.7374C>T	c.(7372-7374)aaC>aaT	p.N2458N	FBN2_ENST00000262464.4_Silent_p.N2458N			P35556	FBN2_HUMAN	fibrillin 2	2458	EGF-like 41; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGGTGCAGAGGTTTGGCATTA	0.413000													21	64					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44054630	44054630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44054630C>T	ENST00000359947.4	+	8	1248	c.908C>T	c.(907-909)tCg>tTg	p.S303L	PTPRF_ENST00000372413.3_Missense_Mutation_p.S303L|PTPRF_ENST00000372414.3_Missense_Mutation_p.S303L|PTPRF_ENST00000438120.1_Missense_Mutation_p.S303L	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	303	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCCATCTCCTCGCTGGGCATG	0.597000													8	25					0	0	1	0	0
ZCCHC24	219654	broad.mit.edu	37	10	81192318	81192318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:81192318G>A	ENST00000372336.3	-	2	629	c.443C>T	c.(442-444)cCc>cTc	p.P148L	ZCCHC24_ENST00000372333.3_Silent_p.P88P	NM_153367.3	NP_699198.2	Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	148							nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)	9						CCTTACCTGGGGGCAGTCCTT	0.652000													15	37					0	0	1	0	0
SLC25A11	8402	broad.mit.edu	37	17	4841131	4841131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:4841131G>A	ENST00000225665.7	-	8	1190	c.850C>T	c.(850-852)Ccg>Tcg	p.P284S	SLC25A11_ENST00000544061.2_Missense_Mutation_p.P233S	NM_001165417.1|NM_003562.4	NP_001158889.1|NP_003553.2	Q02978	M2OM_HUMAN	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	284					gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	10						GCATAGTACGGCGTGAAGCCC	0.592000													21	62					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54922002	54922002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:54922002C>T	ENST00000474759.1	+	24	2121	c.2073C>T	c.(2071-2073)atC>atT	p.I691I	CACNA2D3_ENST00000490478.1_Silent_p.I597I|CACNA2D3-AS1_ENST00000471265.1_RNA|CACNA2D3_ENST00000288197.5_Silent_p.I691I|CACNA2D3_ENST00000415676.2_Silent_p.I691I	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	691						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AAGAATTGATCCAAGAAGTCC	0.532000													40	62					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3557246	3557246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:3557246G>A	ENST00000355415.2	-	1	325	c.156C>T	c.(154-156)gcC>gcT	p.A52A	MFSD12_ENST00000389395.3_Silent_p.A52A|MFSD12_ENST00000591878.1_Intron|MFSD12_ENST00000398558.4_Silent_p.A52A|AC005786.7_ENST00000589360.1_RNA	NM_174983.3	NP_778148.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	52					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						GGGAGCTGTAGGCGCGCACCG	0.711000													8	14					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778336	31778336	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31778336C>T	ENST00000375654.4	-	2	1603	c.1414G>A	c.(1414-1416)Gga>Aga	p.G472R	HSPA1L_ENST00000417199.3_Missense_Mutation_p.G472R	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	472					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TGAGGAACTCCCCTGGGTGCT	0.552000													44	103					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143793092	143793092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143793092G>A	ENST00000408949.2	+	1	952	c.892G>A	c.(892-894)Ggg>Agg	p.G298R		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					AGAGGTGAAAGGGGCTCTAAA	0.463000													97	200					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24188277	24188277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:24188277G>A	ENST00000396671.2	-	7	769	c.421C>T	c.(421-423)Cca>Tca	p.P141S	THRB_ENST00000280696.5_Missense_Mutation_p.P156S|THRB_ENST00000356447.4_Missense_Mutation_p.P141S|THRB_ENST00000416420.1_Missense_Mutation_p.P141S	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	141					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	GAATAGGATGGATGGAGATTT	0.358000													23	91					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137726994	137726994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:137726994G>A	ENST00000371817.3	+	65	5728	c.5314G>A	c.(5314-5316)Gag>Aag	p.E1772K		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1772	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTCCAACGACGAGGAGATGTC	0.657000													14	41					0	0	1	0	0
DDX58	23586	broad.mit.edu	37	9	32493803	32493803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:32493803G>A	ENST00000379882.1	-	2	401	c.244C>T	c.(244-246)Ctg>Ttg	p.L82L	DDX58_ENST00000379868.1_5'UTR|DDX58_ENST00000542096.1_Silent_p.L56L|DDX58_ENST00000545044.1_5'UTR|DDX58_ENST00000379883.2_Silent_p.L127L			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	127	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CATTCAGACAGATCAGAAATG	0.284000													9	45					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12976259	12976259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12976259G>A	ENST00000251472.4	+	15	1807	c.1768G>A	c.(1768-1770)Gac>Aac	p.D590N		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	590	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CTTCTTCGGAGACACACCAGA	0.587000													21	164					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46729621	46729621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:46729621C>T	ENST00000318962.4	-	3	352	c.269G>A	c.(268-270)cGa>cAa	p.R90Q	ALS2CL_ENST00000415953.1_Missense_Mutation_p.R90Q	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	90					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GTCAGCACCTCGCAGCAGCAG	0.612000													7	50					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159165961	159165961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:159165961G>A	ENST00000283233.5	-	9	1407	c.1094C>T	c.(1093-1095)gCt>gTt	p.A365V	CCDC148_ENST00000536771.1_Missense_Mutation_p.A279V|CCDC148_ENST00000409187.1_Missense_Mutation_p.A374V	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	365										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TTTCAGATCAGCACACAATTC	0.403000													25	60					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109740600	109740600	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:109740600G>A	ENST00000369939.3	+	17	2485		c.e17-1		KIAA1324_ENST00000529753.1_Splice_Site|KIAA1324_ENST00000369938.1_Splice_Site	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324						macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		TAATTTGGCAGGGGTGACAAC	0.453000													26	63					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56606836	56606836	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:56606836C>T	ENST00000336078.4	+	6	3464	c.2688C>T	c.(2686-2688)atC>atT	p.I896I	ZNF532_ENST00000589288.1_Silent_p.I896I|ZNF532_ENST00000591808.1_Silent_p.I896I|ZNF532_ENST00000591083.1_Silent_p.I896I|ZNF532_ENST00000591230.1_Silent_p.I896I	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	896					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						ATCCTGGCATCAAGATAGGAG	0.423000													10	117					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50217868	50217868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:50217868G>A	ENST00000338821.5	-	28	3290	c.3026C>T	c.(3025-3027)aCc>aTc	p.T1009I	ATP9A_ENST00000311637.5_Missense_Mutation_p.T873I|ATP9A_ENST00000402822.1_Missense_Mutation_p.T888I	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	1009					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GAATGACAAGGTGGCGATGAA	0.547000													13	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179632515	179632515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179632515G>A	ENST00000589042.1	-	40	9666	c.9442C>T	c.(9442-9444)Cgc>Tgc	p.R3148C	TTN_ENST00000342992.6_Missense_Mutation_p.R3148C|TTN_ENST00000360870.5_Missense_Mutation_p.R3148C|TTN_ENST00000591111.1_Missense_Mutation_p.R3148C|TTN_ENST00000342175.6_Missense_Mutation_p.R3102C|TTN_ENST00000359218.5_Missense_Mutation_p.R3102C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R3102C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2883							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCGGATGCGAACATCTCTG	0.398000													52	177					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818779	159818779	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159818779C>T	ENST00000497452.1	-	0	517																											CGACTCCAGCCTCTTCGAAGA	0.493000													69	200					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52131148	52131148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52131148G>A	ENST00000222107.4	-	5	1074	c.936C>T	c.(934-936)ttC>ttT	p.F312F	SIGLEC5_ENST00000599649.1_Silent_p.F312F|SIGLEC5_ENST00000429354.3_Silent_p.F312F|SIGLEC5_ENST00000570106.2_Silent_p.F312F|SIGLEC5_ENST00000534261.2_Silent_p.F312F			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	312	Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CGCGGCAGGTGAAGCCTCCTT	0.572000													33	66					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34077940	34077940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34077940G>A	ENST00000389232.4	+	66	9416	c.9346G>A	c.(9346-9348)Gac>Aac	p.D3116N	RYR3_ENST00000415757.3_Missense_Mutation_p.D3116N	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3116					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGAAATCAACGACCTGGCCGA	0.552000													29	84					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28654727	28654727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:28654727G>A	ENST00000280904.6	-	12	2253	c.1810C>T	c.(1810-1812)Cat>Tat	p.H604Y	DSC2_ENST00000251081.6_Missense_Mutation_p.H604Y	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	604	Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GGTGGGCCATGGATAGGCTCA	0.413000													17	37					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20486717	20486717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20486717G>A	ENST00000573854.1	+	7	1042	c.928G>A	c.(928-930)Ggt>Agt	p.G310S	ACSM2A_ENST00000417235.2_Missense_Mutation_p.G231S|ACSM2A_ENST00000536134.1_Missense_Mutation_p.G82S|ACSM2A_ENST00000396104.2_Missense_Mutation_p.G310S|ACSM2A_ENST00000219054.6_Missense_Mutation_p.G310S|ACSM2A_ENST00000575690.1_Missense_Mutation_p.G310S|ACSM2A_ENST00000575558.1_3'UTR	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	310					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GAGTATGATGGGTGCCCCCAT	0.512000													34	96					0	0	1	0	0
IKBIP	121457	broad.mit.edu	37	12	99007635	99007635	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:99007635G>A	ENST00000342502.2	-	3	1192	c.781C>T	c.(781-783)Cta>Tta	p.L261L	IKBIP_ENST00000393042.3_3'UTR|IKBIP_ENST00000420861.1_Silent_p.L155L	NM_201612.2	NP_963906.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	261					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						TCTAAGCTTAGAAATCTATCT	0.373000													24	97					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135447862	135447862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:135447862G>A	ENST00000343036.2	+	7	976	c.928G>A	c.(928-930)Ggg>Agg	p.G310R	C9orf171_ENST00000393216.2_Missense_Mutation_p.G274R	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	310										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						CGTGCGCCAGGGGACCCTGCG	0.602000													13	32					0	0	1	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899021	112899021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:112899021C>T	ENST00000374530.3	+	8	1377	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	PALM2-AKAP2_ENST00000302798.7_Silent_p.F399F|AKAP2_ENST00000259318.7_Silent_p.F168F|AKAP2_ENST00000555236.1_Silent_p.F399F|AKAP2_ENST00000374525.1_Silent_p.F257F|AKAP2_ENST00000510514.5_Silent_p.F399F|AKAP2_ENST00000434623.2_Silent_p.F257F	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		168							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						ATGGAGAGTTCACTCTCACCA	0.577000													17	36					0	0	1	0	0
HIGD1B	51751	broad.mit.edu	37	17	42925370	42925370	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:42925370G>A	ENST00000253410.2	+	0	101				HIGD1B_ENST00000587021.1_De_novo_Start_InFrame|HIGD1B_ENST00000591513.1_Intron|HIGD1B_ENST00000590423.1_Intron	NM_016438.2	NP_057522.1	Q9P298	HIG1B_HUMAN	HIG1 hypoxia inducible domain family, member 1B							integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Prostate(33;0.109)				TCAAGTAGAGGCTGTGTTGGG	0.527000													4	3					0	0	1	0	0
FAM129C	199786	broad.mit.edu	37	19	17652952	17652952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17652952C>T	ENST00000335393.4	+	11	1409	c.1271C>T	c.(1270-1272)tCa>tTa	p.S424L	FAM129C_ENST00000599164.1_Missense_Mutation_p.S393L|FAM129C_ENST00000332386.5_Missense_Mutation_p.S424L|FAM129C_ENST00000599124.1_Missense_Mutation_p.S393L|FAM129C_ENST00000300971.2_Missense_Mutation_p.S424L|FAM129C_ENST00000601861.1_Missense_Mutation_p.S393L|FAM129C_ENST00000595684.1_Missense_Mutation_p.S424L|FAM129C_ENST00000449408.2_Missense_Mutation_p.S150L|FAM129C_ENST00000600871.1_Missense_Mutation_p.S370L|FAM129C_ENST00000352727.3_Missense_Mutation_p.S424L	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	424										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						CAGGTTTACTCATTTGGGGAG	0.587000													70	121					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231889	7231889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:7231889C>T	ENST00000383467.2	+	1	767	c.753C>T	c.(751-753)ctC>ctT	p.L251L		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	251										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CGAGCGAACTCCACCTGCTGT	0.572000													40	97					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577743	9577743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9577743G>A	ENST00000301480.4	-	10	2093	c.1880C>T	c.(1879-1881)cCc>cTc	p.P627L		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						ATATTCATAGGGCTTATCTCC	0.393000													46	120					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68661616	68661616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:68661616G>A	ENST00000423218.2	-	3	266	c.171C>T	c.(169-171)gtC>gtT	p.V57V	ITGA11_ENST00000315757.7_Silent_p.V57V			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	57					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GGGCGCCCACGACCAGCCTGG	0.567000													21	86					0	0	1	0	0
HDGFL1	154150	broad.mit.edu	37	6	22570323	22570323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:22570323G>A	ENST00000510882.2	+	1	529	c.519G>A	c.(517-519)gcG>gcA	p.A173A	HDGFL1_ENST00000230012.3_Silent_p.A173A			Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	173	Ala-rich.|Glu-rich.									kidney(1)|large_intestine(3)|lung(7)	11	Ovarian(93;0.163)					Aggcggaggcggagagggcgg	0.756000													3	3					0	0	1	0	0
REPIN1	29803	broad.mit.edu	37	7	150069302	150069302	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150069302C>T	ENST00000397281.2	+	4	1461	c.972C>T	c.(970-972)gcC>gcT	p.A324A	REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000489432.2_Silent_p.A381A|REPIN1_ENST00000425389.2_Silent_p.A324A|REPIN1_ENST00000540729.1_Silent_p.A324A|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000444957.1_Silent_p.A324A	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	324					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CCCAGGCCGCCCCCGGCCCGG	0.731000													4	9					0	0	1	0	0
CYP24A1	1591	broad.mit.edu	37	20	52790077	52790077	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:52790077G>A	ENST00000216862.3	-	1	435	c.42C>T	c.(40-42)ttC>ttT	p.F14F	CYP24A1_ENST00000395955.3_Silent_p.F14F	NM_000782.4	NP_000773.2	Q07973	CP24A_HUMAN	cytochrome P450, family 24, subfamily A, polypeptide 1	14					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GCTGCTGCAGGAAGGCGGCAA	0.687000													3	6					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922862	24922862	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:24922862G>A	ENST00000329468.2	+	1	2322	c.1848G>A	c.(1846-1848)aaG>aaA	p.K616K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ACCCGGGAAAGACATCAGTCT	0.458000													39	75					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81239586	81239586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81239586G>A	ENST00000552864.1	-	4	608	c.406C>T	c.(406-408)Cgc>Tgc	p.R136C		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	136	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						GGAATTATGCGAGAGATATAA	0.473000													20	71					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1903152	1903152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:1903152C>T	ENST00000358771.4	+	4	1100	c.948C>T	c.(946-948)ctC>ctT	p.L316L	SIRPA_ENST00000400068.3_Silent_p.L316L|SIRPA_ENST00000356025.3_Silent_p.L316L	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	316	Ig-like C1-type 2.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		TGAGCTGGCTCCTGGTGAATG	0.547000													45	73					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159504872	159504872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:159504872G>A	ENST00000334857.2	-	1	970	c.926C>T	c.(925-927)tCt>tTt	p.S309F		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					AATCCATTAAGAAATATTTCT	0.388000													16	36					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78032751	78032751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:78032751C>T	ENST00000397545.4	+	9	1439	c.1412C>T	c.(1411-1413)aCc>aTc	p.T471I	CCDC40_ENST00000269318.5_Missense_Mutation_p.T471I|CCDC40_ENST00000374877.3_Missense_Mutation_p.T471I|CCDC40_ENST00000374876.4_Intron	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	471					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTGAGGACACCCGGATTTTA	0.567000													28	68					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	242003063	242003063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242003063G>A	ENST00000310397.8	+	18	2431	c.2431G>A	c.(2431-2433)Ggg>Agg	p.G811R	SNED1_ENST00000401884.1_Missense_Mutation_p.G811R|SNED1_ENST00000342631.6_Missense_Mutation_p.G811R|AC005237.4_ENST00000458377.1_RNA|SNED1_ENST00000405547.3_Missense_Mutation_p.G811R	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	811	EGF-like 12; calcium-binding (Potential).				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		GAACCTCCCAGGGGCCTATGT	0.627000													3	14					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33891923	33891923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33891923G>A	ENST00000504830.1	-	1	374	c.39C>T	c.(37-39)tcC>tcT	p.S13S	ADAMTS12_ENST00000352040.3_Silent_p.S13S|ADAMTS12_ENST00000515401.1_Silent_p.S13S	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	13					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GAGCCACCACGGAAAGGTTTG	0.522000										HNSCC(64;0.19)			52	97					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40564524	40564524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:40564524C>T	ENST00000455577.2	+	6	1870	c.958C>T	c.(958-960)Cct>Tct	p.P320S	PAK6_ENST00000560346.1_Missense_Mutation_p.P320S|PAK6_ENST00000441369.1_Missense_Mutation_p.P320S|PAK6_ENST00000453867.1_Missense_Mutation_p.P320S|PAK6_ENST00000260404.4_Missense_Mutation_p.P320S|PAK6_ENST00000542403.2_Missense_Mutation_p.P320S|RP11-133K1.2_ENST00000558658.1_3'UTR	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	320	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		GACCTTCAGCCCTCTGACCAC	0.687000													51	102					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1389508	1389508	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1389508C>T	ENST00000324385.5	+	5	575	c.417C>T	c.(415-417)ctC>ctT	p.L139L	BAIAP3_ENST00000426824.3_Silent_p.L104L|BAIAP3_ENST00000397488.2_Silent_p.L121L|BAIAP3_ENST00000421665.2_Silent_p.L104L|BAIAP3_ENST00000397489.1_Silent_p.L121L|BAIAP3_ENST00000562208.1_Intron|BAIAP3_ENST00000568887.1_Intron	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	139					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				TGGAGATGCTCTACGAGGAGG	0.682000													7	13					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47253785	47253785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:47253785G>A	ENST00000296861.2	-	2	1036	c.643C>T	c.(643-645)Ccg>Tcg	p.P215S		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	215					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			GAGAAGGACGGGAGTGTGCCA	0.542000													12	60					0	0	1	0	0
SNX29	92017	broad.mit.edu	37	16	12145944	12145944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:12145944C>T	ENST00000566228.1	+	8	1058	c.989C>T	c.(988-990)tCt>tTt	p.S330F		NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	0	PX.				cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						GATTCCCTGTCTTTGAACGGG	0.468000													44	152					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26176114	26176114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26176114G>A	ENST00000335473.7	+	9	2410	c.2160G>A	c.(2158-2160)gtG>gtA	p.V720V	MYO18B_ENST00000536101.1_Silent_p.V720V|MYO18B_ENST00000407587.2_Silent_p.V720V	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	720	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TCTCCATGGTGATGTCGCTGG	0.642000													6	17					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150714259	150714259	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150714259C>T	ENST00000605938.1	-	9	2228	c.2153G>A	c.(2152-2154)tGg>tAg	p.W718*	ATG9B_ENST00000377974.2_Nonsense_Mutation_p.W718*|ATG9B_ENST00000444312.1_Nonsense_Mutation_p.W204*|ATG9B_ENST00000494791.1_5'UTR	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	718					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGGGGCGCCAGAGTGGATG	0.652000													9	18					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162762229	162762229	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:162762229C>T	ENST00000375514.5	+	15	2059	c.1772C>T	c.(1771-1773)gCc>gTc	p.A591V	SLC4A10_ENST00000421911.1_Missense_Mutation_p.A610V|SLC4A10_ENST00000446997.1_Missense_Mutation_p.A610V|SLC4A10_ENST00000272716.5_Missense_Mutation_p.A580V|SLC4A10_ENST00000415876.2_Missense_Mutation_p.A580V	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	610					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						ATACTTGTGGCCACAGATGCT	0.433000													37	87					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53070220	53070220	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53070220C>T	ENST00000252244.3	-	7	1372	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	438	Coil 2.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						TCTTGGCATCCTTGAGGGCAT	0.537000													23	65					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147114176	147114176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:147114176G>A	ENST00000383075.3	-	3	663	c.151C>T	c.(151-153)Ccc>Tcc	p.P51S	ZIC4_ENST00000525172.2_Missense_Mutation_p.P101S|ZIC4_ENST00000425731.3_Missense_Mutation_p.P89S|ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000473123.1_Missense_Mutation_p.P51S|ZIC4_ENST00000484399.1_Missense_Mutation_p.P51S	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	51						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						GAGGCCTGGGGAGGCTCCTCG	0.687000													14	25					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50265441	50265441	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50265441G>A	ENST00000246801.3	-	2	301	c.219C>T	c.(217-219)ctC>ctT	p.L73L		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	73							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		AGGACCGTTTGAGGTTCAGGC	0.612000													9	33					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921186	247921186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247921186G>A	ENST00000408896.2	-	1	796	c.523C>T	c.(523-525)Cat>Tat	p.H175Y		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AAGAAATGATGGATGATATTG	0.478000													6	17					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	93943946	93943946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93943946C>T	ENST00000553484.1	+	4	645	c.491C>T	c.(490-492)cCt>cTt	p.P164L	UNC79_ENST00000555664.1_Missense_Mutation_p.P164L|UNC79_ENST00000256339.4_5'UTR|UNC79_ENST00000393151.2_Missense_Mutation_p.P164L			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	164						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TGTTTGCTACCTTTTCTCAAT	0.338000													25	57					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207175678	207175678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:207175678G>A	ENST00000374423.3	+	5	6812	c.6426G>A	c.(6424-6426)aaG>aaA	p.K2142K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2142							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AGCTTCCAAAGAAAAGAAATT	0.358000													20	71					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113388725	113388725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113388725C>T	ENST00000228928.7	+	7	1781	c.1602C>T	c.(1600-1602)tcC>tcT	p.S534S	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	534	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						AGCTGGTGTCCACAGCCCTGA	0.612000													21	40					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060071	54060071	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54060071G>A	ENST00000312233.2	-	3	1071	c.505C>T	c.(505-507)Ccc>Tcc	p.P169S		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	169					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						TGAGACAGGGGATAGGGGGGC	0.687000													12	15					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108076874	108076874	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108076874G>A	ENST00000357759.5	+	6	1283	c.869G>A	c.(868-870)tGg>tAg	p.W290*	HHLA2_ENST00000467761.1_Nonsense_Mutation_p.W290*|HHLA2_ENST00000467562.1_Nonsense_Mutation_p.W226*|HHLA2_ENST00000489514.2_Nonsense_Mutation_p.W290*|HHLA2_ENST00000491820.1_Nonsense_Mutation_p.W290*	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	290	Ig-like V-type 2.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						CGATTCTCATGGAACAAAGAG	0.373000													63	149					0	0	1	0	0
POFUT1	23509	broad.mit.edu	37	20	30797941	30797941	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30797941C>T	ENST00000375749.3	+	2	254	c.192C>T	c.(190-192)acC>acT	p.T64T	POFUT1_ENST00000486717.1_Intron|POFUT1_ENST00000539210.1_Intron|POFUT1_ENST00000375730.3_Silent_p.T64T	NM_015352.1	NP_056167.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	64					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TAAACCGTACCTTGGCTGTCC	0.547000													27	195					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36166615	36166615	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:36166615C>T	ENST00000303965.4	-	11	2583	c.2094G>A	c.(2092-2094)agG>agA	p.R698R		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	698	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTGCACAGCTCCTGTTGGATT	0.428000													17	73					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10476376	10476376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10476376G>A	ENST00000525621.1	-	7	1309	c.828C>T	c.(826-828)ccC>ccT	p.P276P	TYK2_ENST00000264818.6_Silent_p.P276P|TYK2_ENST00000529370.1_Silent_p.P276P|TYK2_ENST00000524462.1_Silent_p.P91P	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	276	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.P276P(1)		breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GGTGGCACACGGGCACACGCT	0.677000													8	22					0	0	1	0	0
ILVBL	10994	broad.mit.edu	37	19	15234287	15234287	+	Missense_Mutation	SNP	G	G	A	rs34470764		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15234287G>A	ENST00000263383.3	-	3	375	c.236C>T	c.(235-237)tCc>tTc	p.S79F	ILVBL_ENST00000531635.1_5'UTR|ILVBL_ENST00000534378.1_5'UTR	NM_006844.3	NP_006835.2	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	79						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)	26						CAGCAGCGGGGAAATGTGCCC	0.637000													28	67					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113275932	113275932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113275932G>A	ENST00000297405.5	-	61	10042	c.9798C>T	c.(9796-9798)tcC>tcT	p.S3266S	CSMD3_ENST00000455883.2_Silent_p.S3097S|CSMD3_ENST00000343508.3_Silent_p.S3226S|CSMD3_ENST00000352409.3_Silent_p.S3196S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3266	Sushi 25.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAGCAGGGAAGGATAGCTCAT	0.453000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			18	48					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119428057	119428057	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:119428057G>A	ENST00000369429.3	-	8	1116	c.1107C>T	c.(1105-1107)tcC>tcT	p.S369S	TBX15_ENST00000207157.3_Silent_p.S263S			Q96SF7	TBX15_HUMAN	T-box 15	369						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GAGGAGAACAGGATGGAGATA	0.498000													7	19					0	0	1	0	0
ZNF696	79943	broad.mit.edu	37	8	144378516	144378516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144378516C>T	ENST00000330143.3	+	3	1080	c.671C>T	c.(670-672)gCc>gTc	p.A224V		NM_030895.2	NP_112157.2	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			AGGTCGGACGCCGCCAAGCAC	0.721000													4	11					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62373637	62373637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:62373637G>A	ENST00000394773.2	-	13	1861	c.1554C>T	c.(1552-1554)ttC>ttT	p.F518F	EML3_ENST00000529309.1_Silent_p.F518F|EML3_ENST00000278845.4_Silent_p.F519F|RP11-831H9.3_ENST00000532626.1_RNA|EML3_ENST00000494176.2_Silent_p.F490F|EML3_ENST00000531557.1_Silent_p.F301F|EML3_ENST00000438258.1_5'UTR	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	518						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						GACACAAGGCGAAGATAGAAC	0.637000													31	63					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781930	128781930	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128781930G>A	ENST00000529694.1	+	2	1138	c.762G>A	c.(760-762)caG>caA	p.Q254Q	KCNJ5_ENST00000338350.4_Silent_p.Q254Q|KCNJ5_ENST00000533599.1_Silent_p.Q254Q	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	254					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CCCTGAACCAGACAGACATCA	0.592000													20	131					0	0	1	0	0
CELF6	60677	broad.mit.edu	37	15	72581617	72581617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:72581617G>A	ENST00000287202.5	-	8	1146	c.892C>T	c.(892-894)Ccg>Tcg	p.P298S	RP11-106M3.3_ENST00000570175.1_RNA|RP11-106M3.2_ENST00000379915.4_RNA|CELF6_ENST00000395258.2_Missense_Mutation_p.P185S|CELF6_ENST00000543764.2_Missense_Mutation_p.P182S|CELF6_ENST00000539635.1_Missense_Mutation_p.P159S|CELF6_ENST00000567083.1_Missense_Mutation_p.P298S	NM_052840.4	NP_443072.3	Q96J87	CELF6_HUMAN	CUGBP, Elav-like family member 6	298					mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(2)	13						CTGCCAGGCGGGGAGTTGGCT	0.731000													5	8					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83348509	83348509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:83348509G>A	ENST00000261722.3	-	10	1361	c.1154C>T	c.(1153-1155)aCc>aTc	p.T385I	AP3B2_ENST00000535348.1_Missense_Mutation_p.T353I|AP3B2_ENST00000535359.1_Missense_Mutation_p.T385I|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	385					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGTGGGGTCGGTGGACCTGAT	0.577000													29	48					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92999147	92999147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:92999147C>T	ENST00000523629.1	-	8	1499	c.1045G>A	c.(1045-1047)Gaa>Aaa	p.E349K	RUNX1T1_ENST00000520724.1_Missense_Mutation_p.E312K|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.E312K|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.E360K|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.E322K|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.E312K|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.E349K|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.E322K	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	349	Important for oligomerization.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCTGCCCATTCTCTGTCTGTT	0.383000													43	113					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4409622	4409622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4409622C>T	ENST00000301280.5	+	3	927	c.826C>T	c.(826-828)Ccc>Tcc	p.P276S		NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	276	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAATCTTTCCCCGAAGAAGA	0.592000								Chromatin Structure					20	51					0	0	1	0	0
OVOL1	5017	broad.mit.edu	37	11	65562597	65562597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65562597C>T	ENST00000335987.3	+	4	941	c.589C>T	c.(589-591)Cat>Tat	p.H197Y	OVOL1_ENST00000532448.1_Missense_Mutation_p.H135Y	NM_004561.3	NP_004552.2	O14753	OVOL1_HUMAN	ovo-like zinc finger 1	197					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	6				READ - Rectum adenocarcinoma(159;0.17)		CAAGAAGATCCATGGTGTGCA	0.627000													13	57					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79067090	79067090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79067090G>A	ENST00000388820.4	-	12	1962	c.1752C>T	c.(1750-1752)ttC>ttT	p.F584F	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	584	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						TGCAGAGGCGGAAGCGCTTGC	0.637000													16	70					0	0	1	0	0
RAMP1	10267	broad.mit.edu	37	2	238820283	238820283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:238820283G>A	ENST00000254661.4	+	3	437	c.305G>A	c.(304-306)aGg>aAg	p.R102K	RAMP1_ENST00000409726.1_Missense_Mutation_p.R80K|RAMP1_ENST00000404910.2_Missense_Mutation_p.R80K|RAMP1_ENST00000403885.1_Missense_Mutation_p.R80K	NM_005855.2	NP_005846.1	O60894	RAMP1_HUMAN	receptor (G protein-coupled) activity modifying protein 1	102					intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity			kidney(1)|large_intestine(1)|lung(2)	4		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	CGCTACTTCAGGAGCTGCCCC	0.657000													18	40					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53413751	53413751	+	Splice_Site	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:53413751T>C	ENST00000371514.3	+	3	366	c.199_splice	c.e3+1	p.F66_splice	SCP2_ENST00000407246.2_Intron|SCP2_ENST00000371513.5_Splice_Site_p.F66_splice|SCP2_ENST00000371509.4_Splice_Site_p.F66_splice|SCP2_ENST00000528311.1_5'UTR	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	66					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						GCTATGTTTTTGGTATGTATT	0.353000													37	139					0	0	1	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89476608	89476608	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89476608G>A	ENST00000484817.1	-	0	36																											TGAGCAAGGAGCCTCATTGTG	0.552000													4	27					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1537698	1537698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1537698C>T	ENST00000447419.2	-	2	440	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	PTX4_ENST00000293922.1_Missense_Mutation_p.E134K|PTX4_ENST00000440447.2_Intron			Q96A99	PTX4_HUMAN	pentraxin 4, long	139						extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						GCCTTCCTTTCCCGGGCCCGC	0.706000													18	40					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30202521	30202521	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:30202521G>A	ENST00000397771.2	-	12	1215	c.1038C>T	c.(1036-1038)ttC>ttT	p.F346F	ASCC2_ENST00000542393.1_Silent_p.F270F|ASCC2_ENST00000307790.3_Silent_p.F346F|ASCC2_ENST00000478812.1_5'UTR			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			ACTCTTCGATGAAGCCCTGAA	0.552000													12	30					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117232171	117232171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:117232171C>T	ENST00000003084.6	+	14	2082	c.1950C>T	c.(1948-1950)ttC>ttT	p.F650F	CFTR_ENST00000454343.1_Silent_p.F589F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	650					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding	p.F650F(1)		NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GTGATTCTTTCGACCAATTTA	0.383000									Cystic Fibrosis				14	92					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21742337	21742337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21742337G>A	ENST00000328843.6	+	38	6242	c.6211G>A	c.(6211-6213)Gac>Aac	p.D2071N	DNAH11_ENST00000409508.3_Missense_Mutation_p.D2064N			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2071	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GGATCATTACGACTGGGGACT	0.383000									Kartagener syndrome				10	26					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50195622	50195622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:50195622C>T	ENST00000392518.4	+	3	485	c.113C>T	c.(112-114)tCc>tTc	p.S38F	CPT1C_ENST00000405931.2_Missense_Mutation_p.S38F|CPT1C_ENST00000323446.5_Missense_Mutation_p.S38F|CPT1C_ENST00000354199.5_Missense_Mutation_p.S38F|CPT1C_ENST00000598293.1_Missense_Mutation_p.S38F|CPT1C_ENST00000598714.1_3'UTR	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	38					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GGCCTGCGCTCCTGGAAAAGG	0.617000													15	28					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24805461	24805461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24805461G>A	ENST00000216274.5	-	10	1695	c.1477C>T	c.(1477-1479)Cca>Tca	p.P493S	RP11-934B9.3_ENST00000555591.1_Intron	NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	493					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		GAACCTACTGGTGGGGGGTGC	0.547000													9	92					0	0	1	0	0
LPCAT4	254531	broad.mit.edu	37	15	34656261	34656261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:34656261G>A	ENST00000314891.6	-	5	782	c.605C>T	c.(604-606)cCt>cTt	p.P202L		NM_153613.2	NP_705841.2	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	202					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding			NS(1)|breast(1)|large_intestine(2)|lung(5)|prostate(1)	10						GGTGCCCTCAGGAAAGAATAG	0.458000													51	132					0	0	1	0	0
SEPT2	4735	broad.mit.edu	37	2	242285635	242285635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:242285635C>T	ENST00000391973.2	+	10	1425	c.897C>T	c.(895-897)ttC>ttT	p.F299F	SEPT2_ENST00000402092.2_Silent_p.F299F|SEPT2_ENST00000407971.1_Silent_p.F259F|SEPT2_ENST00000391971.2_Silent_p.F299F|SEPT2_ENST00000401990.1_Silent_p.F309F|SEPT2_ENST00000360051.3_Silent_p.F299F	NM_006155.1	NP_006146.1	Q15019	SEPT2_HUMAN	septin 2	299					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		ATGAAAACTTCCGTTCTGAGA	0.507000													11	62					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86114835	86114835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:86114835C>T	ENST00000383699.3	+	9	1678	c.1051C>T	c.(1051-1053)Ctg>Ttg	p.L351L	CADM2_ENST00000407528.2_Silent_p.L382L|CADM2_ENST00000405615.2_Silent_p.L384L	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	382					adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ATTTGTCACGCTGTGTTCTAT	0.423000													12	64					0	0	1	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19209673	19209673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19209673G>A	ENST00000375341.3	-	7	880	c.623C>T	c.(622-624)tCg>tTg	p.S208L	ALDH4A1_ENST00000290597.5_Missense_Mutation_p.S208L|ALDH4A1_ENST00000454547.1_5'UTR|ALDH4A1_ENST00000538309.1_Missense_Mutation_p.S148L|RP13-279N23.2_ENST00000494072.3_3'UTR|ALDH4A1_ENST00000538839.1_Missense_Mutation_p.S208L	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	208					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	GTTAAAGGGCGAGATGGCCGC	0.672000													32	65					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48613161	48613161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48613161G>A	ENST00000328333.8	-	72	5984	c.5877C>T	c.(5875-5877)atC>atT	p.I1959I	COL7A1_ENST00000454817.1_Silent_p.I1927I	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1959	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGTCTCCACGATCTCCCGCA	0.682000													29	65					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124982286	124982286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124982286C>T	ENST00000522917.1	+	6	602	c.396C>T	c.(394-396)ttC>ttT	p.F132F	FER1L6_ENST00000399018.1_Silent_p.F132F	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	132	C2 1.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACTTTGTCTTCGACTTCATTG	0.413000													28	75					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102667464	102667464	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102667464G>A	ENST00000315274.6	-	4	623	c.556C>T	c.(556-558)Caa>Taa	p.Q186*	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	186	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		GGGCCTGGTTGAAAAGCATGA	0.418000													29	67					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29230635	29230635	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29230635C>T	ENST00000441381.1	+	0	79																											AAACAGGTCCCAAATGCTTTT	0.428000													39	80					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112043097	112043097	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:112043097G>A	ENST00000241356.4	-	2	837	c.432C>T	c.(430-432)acC>acT	p.T144T	ADORA3_ENST00000369716.4_Intron|ADORA3_ENST00000369717.4_Intron	NM_000677.3	NP_000668.1	P33765	AA3R_HUMAN	adenosine A3 receptor	144					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	CAAACATGGGGGTCAATCCCA	0.488000													45	112					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102221052	102221052	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102221052T>A	ENST00000227758.2	+	2	1866	c.467T>A	c.(466-468)cTt>cAt	p.L156H	BIRC2_ENST00000527910.1_3'UTR|BIRC2_ENST00000530675.1_Missense_Mutation_p.L107H|BIRC2_ENST00000532672.1_Missense_Mutation_p.L135H	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	156					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		TACTCCAGCCTTTCTCCAAAC	0.418000													32	150					0	0	1	0	0
GPIHBP1	338328	broad.mit.edu	37	8	144295145	144295145	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:144295145G>A	ENST00000330824.2	+	1	78	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	1					cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CCGGCGAGATGAAGGCGCTCG	0.662000													3	7					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48704860	48704860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:48704860G>A	ENST00000316623.5	-	65	8587	c.8132C>T	c.(8131-8133)tCc>tTc	p.S2711F	FBN1_ENST00000561429.1_5'UTR	NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2711					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGCCTCTGGGGAGAGTGAATT	0.532000													59	144					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67681486	67681486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67681486G>A	ENST00000334583.6	+	11	1180	c.852G>A	c.(850-852)ggG>ggA	p.G284G	RLTPR_ENST00000545661.1_Silent_p.G284G	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	284										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GCCTCGCGGGGAACCTGCTGG	0.672000													8	5					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94933565	94933565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94933565C>T	ENST00000337425.5	-	3	911	c.837G>A	c.(835-837)atG>atA	p.M279I	SERPINA9_ENST00000448305.2_Missense_Mutation_p.M181I|SERPINA9_ENST00000424550.2_Missense_Mutation_p.M130I|SERPINA9_ENST00000546329.1_Missense_Mutation_p.M243I|SERPINA9_ENST00000380365.3_Missense_Mutation_p.M261I|SERPINA9_ENST00000298845.7_Missense_Mutation_p.M179I	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	261					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CCTTGTAATCCATCTGCAGCA	0.537000													17	45					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507679	155507679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155507679C>T	ENST00000302053.3	-	5	980	c.902G>A	c.(901-903)gGa>gAa	p.G301E	FGA_ENST00000403106.3_Missense_Mutation_p.G301E	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	301					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ACTTCCAGGTCCAGAGCTCCC	0.577000													53	145					0	0	1	0	0
NRL	4901	broad.mit.edu	37	14	24552051	24552051	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:24552051G>A	ENST00000561028.1	-	2	326	c.7C>T	c.(7-9)Ctg>Ttg	p.L3L	NRL_ENST00000397002.2_Silent_p.L3L|NRL_ENST00000396997.1_Silent_p.L3L			P54845	NRL_HUMAN	neural retina leucine zipper	3					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding			lung(2)	2				GBM - Glioblastoma multiforme(265;0.0181)		CTGGGGGGCAGGGCCATTCTG	0.602000													11	45					0	0	1	0	0
CARD9	64170	broad.mit.edu	37	9	139264207	139264207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139264207C>T	ENST00000371732.5	-	7	1237	c.1072G>A	c.(1072-1074)Gac>Aac	p.D358N	CARD9_ENST00000315908.7_Missense_Mutation_p.D358N|CARD9_ENST00000371734.3_Missense_Mutation_p.D358N	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	358					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		CCCACCTGGTCCCGCTCAATG	0.612000													4	5					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150844496	150844496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:150844496G>A	ENST00000370357.4	+	16	2448	c.2203G>A	c.(2203-2205)Gga>Aga	p.G735R		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	735						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGTCGAGGGACCTCCTGA	0.527000													80	57					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36228084	36228084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36228084C>T	ENST00000420124.1	+	33	7470	c.7470C>T	c.(7468-7470)ttC>ttT	p.F2490F	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Silent_p.F2490F																							ACTATAAGTTCCGTTACCACC	0.632000													5	7					0	0	1	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16855835	16855835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:16855835G>A	ENST00000261652.2	-	2	136	c.124C>T	c.(124-126)Cct>Tct	p.P42S	TNFRSF13B_ENST00000583789.1_Intron|TNFRSF13B_ENST00000437538.2_Intron|TNFRSF13B_ENST00000579315.1_Missense_Mutation_p.P42S|TNFRSF13B_ENST00000581616.2_5'UTR	NM_012452.2	NP_036584.1	O14836	TR13B_HUMAN	tumor necrosis factor receptor superfamily, member 13B	42					cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|skin(1)	16						CCCAGCAGAGGATCCCAGTAC	0.617000									IgA Deficiency, Selective				19	25					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89619494	89619494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:89619494C>T	ENST00000268704.2	+	14	1902	c.1887C>T	c.(1885-1887)gcC>gcT	p.A629A		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	629					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		TGTGCATGGCCCTGGGAGGAC	0.622000													8	26					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	404911	404911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:404911C>T	ENST00000399788.2	-	26	4645	c.4283G>A	c.(4282-4284)cGa>cAa	p.R1428Q	KDM5A_ENST00000382815.4_Missense_Mutation_p.R1428Q	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1428					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						TTCCAAACTTCGGGGCACCAA	0.448000			T	NUP98	AML								58	119					0	0	1	0	0
GH2	2689	broad.mit.edu	37	17	61957617	61957617	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:61957617G>A	ENST00000456543.2	-	5	754	c.714C>T	c.(712-714)ctC>ctT	p.L238L	GH2_ENST00000449787.2_3'UTR|GH2_ENST00000423893.2_3'UTR|GH2_ENST00000332800.7_3'UTR			P01242	SOM2_HUMAN	growth hormone 2	0						extracellular region	hormone activity			breast(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	24						GTGGGCACTGGAGTAGCACCT	0.552000													14	28					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872446	51872446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51872446C>T	ENST00000371497.5	+	2	3336	c.2449C>T	c.(2449-2451)Ccc>Tcc	p.P817S	TSHZ2_ENST00000603338.2_Missense_Mutation_p.P814S|TSHZ2_ENST00000329613.6_Missense_Mutation_p.P814S	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	817					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CTCCAGGGTCCCCCCCATGAA	0.552000													34	82					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89156913	89156913	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:89156913C>T	ENST00000336596.2	+	1	240	c.15C>T	c.(13-15)ctC>ctT	p.L5L	EPHA3_ENST00000494014.1_Silent_p.L5L|EPHA3_ENST00000452448.2_Silent_p.L5L	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	5						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATTGTCAGCTCTCCATCCTCC	0.562000										TSP Lung(6;0.00050)			30	130					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107450550	107450550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:107450550C>T	ENST00000409382.3	-	3	1606	c.996G>A	c.(994-996)gaG>gaA	p.E332E	ST6GAL2_ENST00000409087.3_Silent_p.E332E|ST6GAL2_ENST00000361686.4_Silent_p.E332E	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	332					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CAACATCTTTCTCATAACCAC	0.388000													35	105					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54305718	54305718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:54305718C>T	ENST00000545554.1	+	1	618	c.618C>T	c.(616-618)tcC>tcT	p.S206S	UNC13C_ENST00000537900.1_Silent_p.S206S|UNC13C_ENST00000260323.11_Silent_p.S206S			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	206					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGAAAAAATCCTGGGGAATAA	0.438000													39	112					0	0	1	0	0
CCBL1	883	broad.mit.edu	37	9	131607688	131607688	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:131607688G>A	ENST00000436267.2	-	4	428	c.279C>T	c.(277-279)ctC>ctT	p.L93L	CCBL1_ENST00000302586.3_5'UTR|CCBL1_ENST00000320665.6_5'UTR|CCBL1_ENST00000483599.1_5'UTR			Q16773	KAT1_HUMAN	cysteine conjugate-beta lyase, cytoplasmic	0					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	TGGCCATGGCGAGCTGGAGAC	0.627000													7	20					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158596785	158596785	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:158596785C>T	ENST00000368148.3	-	41	5857	c.5677G>A	c.(5677-5679)Gaa>Aaa	p.E1893K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1890K|SPTA1_ENST00000461624.1_5'UTR	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1893					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTCTGACTTTCCTCCTGCAAC	0.423000													44	141					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11302032	11302032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:11302032G>A	ENST00000397056.1	+	3	1500	c.1309G>A	c.(1309-1311)Gtc>Atc	p.V437I	HRH1_ENST00000431010.2_Missense_Mutation_p.V437I|HRH1_ENST00000438284.2_Missense_Mutation_p.V437I	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	437					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	CTTCTTCATGGTCATTGCCTT	0.488000													79	240					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79066542	79066542	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79066542G>A	ENST00000388820.4	-	13	2187	c.1977C>T	c.(1975-1977)gcC>gcT	p.A659A	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	659	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GGTCCCGGCTGGCTCGGACCT	0.662000													5	13					0	0	1	0	0
FAM26E	254228	broad.mit.edu	37	6	116836979	116836979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:116836979C>T	ENST00000368599.3	+	2	808	c.757C>T	c.(757-759)Cct>Tct	p.P253S	TRAPPC3L_ENST00000368602.3_Intron	NM_153711.2	NP_714922.1	Q8N5C1	FA26E_HUMAN	family with sequence similarity 26, member E	253						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7		all_cancers(87;0.0608)|all_epithelial(87;0.05)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0242)|all cancers(137;0.0419)|OV - Ovarian serous cystadenocarcinoma(136;0.0671)|Epithelial(106;0.212)		GAGGCCAGATCCTTTTCCCAT	0.478000													38	38					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13414658	13414658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13414658C>T	ENST00000360228.5	-	16	2026	c.2027G>A	c.(2026-2028)gGg>gAg	p.G676E	CACNA1A_ENST00000573710.2_Missense_Mutation_p.G677E	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	677					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AGACTTGATCCCGTCGTACAT	0.557000													121	74					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024398	76024398	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76024398G>A	ENST00000393004.2	-	5	1371	c.1150C>T	c.(1150-1152)Cga>Tga	p.R384*	FILIP1_ENST00000237172.7_Nonsense_Mutation_p.R384*|FILIP1_ENST00000370020.1_Nonsense_Mutation_p.R285*|FILIP1_ENST00000498523.1_5'UTR			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	384										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						ACACGCTTTCGAAGATTTTCC	0.418000													13	156					0	0	1	0	0
GNRHR	2798	broad.mit.edu	37	4	68610309	68610309	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:68610309C>T	ENST00000226413.4	-	2	743	c.719G>A	c.(718-720)cGg>cAg	p.R240Q	RP11-453E17.1_ENST00000500538.2_RNA|GNRHR_ENST00000420975.2_Silent_p.T197T|RP11-453E17.1_ENST00000502758.1_RNA	NM_000406.2	NP_000397.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	240					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	ATGAAGGACCCGTGTCAGGGT	0.418000													14	66					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665966	19665966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:19665966G>A	ENST00000328041.6	+	12	1482	c.1285G>A	c.(1285-1287)Gat>Aat	p.D429N		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	429						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ggaggacgaggatgatgatga	0.517000													22	68					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111427208	111427208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:111427208G>A	ENST00000393934.3	+	2	1169	c.599G>A	c.(598-600)cGa>cAa	p.R200Q	PLCXD2_ENST00000477665.1_Missense_Mutation_p.R200Q	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	200	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity	p.R200Q(1)		endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						TTGACGCTGCGAACTCTGTGG	0.512000													19	52					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450996	55450996	+	Silent	SNP	G	G	A	rs147899515		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:55450996G>A	ENST00000588756.1	-	6	1677	c.1191C>T	c.(1189-1191)ttC>ttT	p.F397F	NLRP7_ENST00000328092.5_Silent_p.F397F|NLRP7_ENST00000340844.2_Silent_p.F397F|NLRP7_ENST00000448121.2_Silent_p.F397F|NLRP7_ENST00000590030.1_Silent_p.F397F|NLRP7_ENST00000592784.1_Silent_p.F397F|NLRP7_ENST00000446217.1_Silent_p.F425F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	397	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GGCTGCAGAGGAAACGCAGGA	0.697000													12	22					0	0	1	0	0
ZFAT	57623	broad.mit.edu	37	8	135613910	135613910	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:135613910G>A	ENST00000520727.1	-	7	2315	c.2016C>T	c.(2014-2016)ctC>ctT	p.L672L	ZFAT_ENST00000520214.1_Silent_p.L672L|ZFAT_ENST00000377838.3_Silent_p.L684L|ZFAT_ENST00000523399.1_Silent_p.L622L|ZFAT_ENST00000429442.2_Silent_p.L672L|ZFAT_ENST00000520356.1_Silent_p.L672L	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	684			R -> K (in dbSNP:rs35003767).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTGGAGGGAGGAGGTCTGAGG	0.597000													6	77					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69352210	69352210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:69352210G>A	ENST00000193403.6	-	12	1700	c.1317C>T	c.(1315-1317)gcC>gcT	p.A439A	ACTN1_ENST00000538545.2_Silent_p.A439A|ACTN1_ENST00000376839.3_Silent_p.A374A|ACTN1_ENST00000438964.2_Silent_p.A439A|ACTN1_ENST00000394419.4_Silent_p.A439A	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	439	Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CACTCTCGAAGGCCTCATGCT	0.617000													12	40					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862608	5862608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5862608G>A	ENST00000329322.5	-	1	519	c.520C>T	c.(520-522)Cgt>Tgt	p.R174C	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Missense_Mutation_p.R178C	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R178C(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGATGATACGATGTCCACAG	0.478000													39	107					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159166610	159166610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:159166610C>T	ENST00000297239.9	+	11	1148	c.954C>T	c.(952-954)ttC>ttT	p.F318F	SYTL3_ENST00000367081.3_Silent_p.F44F|SYTL3_ENST00000360448.3_Silent_p.F250F			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	318	C2 1.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		ATTATTGCTTCAAAACCCATT	0.358000													6	14					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216172336	216172336	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:216172336T>C	ENST00000366943.2	-	34	6936	c.6550A>G	c.(6550-6552)Aca>Gca	p.T2184A	USH2A_ENST00000307340.3_Missense_Mutation_p.T2184A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2184	Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAATCATGTGTATGGTTTGAC	0.318000										HNSCC(13;0.011)			29	89					0	0	1	0	0
LDLRAD2	401944	broad.mit.edu	37	1	22140990	22140990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:22140990C>T	ENST00000344642.2	+	2	372	c.185C>T	c.(184-186)aCc>aTc	p.T62I	LDLRAD2_ENST00000543870.1_Missense_Mutation_p.T62I	NM_001013693.2	NP_001013715.2	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain containing 2	62						integral to membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)	6		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		GCTCCGGACACCGACTGCGGG	0.726000													8	47					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2377216	2377216	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:2377216C>T	ENST00000202625.2	+	4	550	c.489C>T	c.(487-489)atC>atT	p.I163I	TGM6_ENST00000381423.1_Silent_p.I163I|TGM6_ENST00000477505.1_Intron	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	163					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	ACAGCGGCATCATCTTCCGAG	0.617000													17	51					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71036137	71036137	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:71036137G>A	ENST00000452400.2	-	21	4456	c.4275C>T	c.(4273-4275)tcC>tcT	p.S1425S	NCOA2_ENST00000267974.4_Silent_p.S513S	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1425					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GACCCATGGAGGACAGCCCTG	0.522000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								9	14					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131261477	131261477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:131261477C>T	ENST00000512055.1	-	19	3589	c.1463G>A	c.(1462-1464)gGg>gAg	p.G488E	CPNE4_ENST00000512332.1_Missense_Mutation_p.G506E|CPNE4_ENST00000502818.1_Missense_Mutation_p.G506E|CPNE4_ENST00000429747.1_Missense_Mutation_p.G488E|CPNE4_ENST00000511604.1_Missense_Mutation_p.G488E			Q96A23	CPNE4_HUMAN	copine IV	488	VWFA.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						CCTCAGAATCCCATCATCACC	0.537000													22	78					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354135	57354135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:57354135C>T	ENST00000314922.3	-	2	576	c.500G>A	c.(499-501)cGa>cAa	p.R167Q	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.R167Q	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	167					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCTACGCTCTCGGTTGTCCCC	0.527000													8	136					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3046493	3046493	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:3046493G>A	ENST00000520002.1	-	36	5997	c.5442C>T	c.(5440-5442)atC>atT	p.I1814I	CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000542608.1_Silent_p.I1813I|CSMD1_ENST00000400186.3_Silent_p.I1814I|CSMD1_ENST00000602557.1_Silent_p.I1814I|CSMD1_ENST00000537824.1_Silent_p.I1813I|CSMD1_ENST00000602723.1_Silent_p.I1814I|CSMD1_ENST00000539096.1_Silent_p.I1813I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1814	CUB 11.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGGGGGACAGGATTGTACCTC	0.463000													6	20					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68939473	68939473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:68939473G>A	ENST00000288368.4	+	5	735	c.458G>A	c.(457-459)gGa>gAa	p.G153E	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	153	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						ATGCTGCTTGGAGGACGGAAG	0.348000													29	76					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249484	52249484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52249484G>A	ENST00000595042.1	-	3	905	c.764C>T	c.(763-765)tCc>tTc	p.S255F	FPR1_ENST00000304748.4_Missense_Mutation_p.S255F	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	255					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CTGATATGGGGACCAGCAGAG	0.498000													15	36					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404283	124404283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:124404283G>A	ENST00000303921.2	-	1	1398	c.748C>T	c.(748-750)Ccc>Tcc	p.P250S		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	250						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GGGTAGAAGGGGTTCTTCAGT	0.622000													16	47					0	0	1	0	0
DAW1	164781	broad.mit.edu	37	2	228754612	228754612	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228754612G>A	ENST00000373666.2	+	3	790	c.154G>A	c.(154-156)Gaa>Aaa	p.E52K	DAW1_ENST00000545118.1_Missense_Mutation_p.E37K|DAW1_ENST00000309931.2_Missense_Mutation_p.E52K|DAW1_ENST00000472604.1_3'UTR					dynein assembly factor with WDR repeat domains 1																		CCAGAAGGCAGAACCTCTACT	0.383000													27	65					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140356050	140356050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:140356050G>A	ENST00000406427.1	-	33	4115	c.3779C>T	c.(3778-3780)tCc>tTc	p.S1260F	PNPLA7_ENST00000371457.1_Missense_Mutation_p.S841F|PNPLA7_ENST00000492278.1_5'UTR|PNPLA7_ENST00000277531.4_Missense_Mutation_p.S1235F	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1235					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GTCCGTGAAGGAGGCGTTGGG	0.652000													8	33					0	0	1	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16734078	16734078	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:16734078C>T	ENST00000297967.5	+	1	178	c.79C>T	c.(79-81)Ctg>Ttg	p.L27L	NLGN4Y_ENST00000476359.1_3'UTR	NM_001164238.1	NP_001157710.1	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked	27					brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity			large_intestine(3)|lung(7)|prostate(2)|skin(2)	14						CAATGTTCTTCTGTGGATAAC	0.458000													16	38					0	0	1	0	0
ZNF812	729648	broad.mit.edu	37	19	9801565	9801565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9801565G>A	ENST00000457674.2	-	5	1132	c.614C>T	c.(613-615)tCc>tTc	p.S205F	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAGGTGTGAGGAATGAGTGAT	0.368000													12	19					0	0	1	0	0
OR56A4	120793	broad.mit.edu	37	11	6023414	6023414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:6023414C>T	ENST00000330728.4	-	1	1010	c.965G>A	c.(964-966)aGa>aAa	p.R322K		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGAGGAATTCTCTTCCTGGC	0.532000													15	43					0	0	1	0	0
OR6C76	390326	broad.mit.edu	37	12	55820223	55820223	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:55820223G>A	ENST00000328314.3	+	1	186	c.186G>A	c.(184-186)agG>agA	p.R62R		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TCTTCCTCAGGAATTTCTCCT	0.393000													56	138					0	0	1	0	0
TDG	6996	broad.mit.edu	37	12	104376924	104376924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:104376924C>T	ENST00000392872.3	+	6	859	c.625C>T	c.(625-627)Cgt>Tgt	p.R209C	TDG_ENST00000544861.1_Missense_Mutation_p.R66C|TDG_ENST00000542036.1_Intron|TDG_ENST00000266775.9_Missense_Mutation_p.R205C	NM_003211.4	NP_003202.3	Q13569	TDG_HUMAN	thymine-DNA glycosylase	209					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			large_intestine(2)|lung(14)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(302;0.00114)		TAAAGAATTTCGTGAAGGAGG	0.249000								Base excision repair (BER), DNA glycosylases					39	146					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21840889	21840889	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21840889G>T	ENST00000328843.6	+	63	10213	c.10182G>T	c.(10180-10182)gaG>gaT	p.E3394D	DNAH11_ENST00000409508.3_Missense_Mutation_p.E3387D			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3394	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGGAACTTGAGGCAAGTTAAA	0.358000									Kartagener syndrome				3	25					0.150653	0.150659	1	1	0
NPHS1	4868	broad.mit.edu	37	19	36332717	36332717	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36332717G>A	ENST00000378910.5	-	20	2714	c.2715C>T	c.(2713-2715)acC>acT	p.T905T	NPHS1_ENST00000353632.6_Silent_p.T905T	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	905	Ig-like C2-type 8.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGTTGGCAATGGTCAGGAGGC	0.557000													9	21					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256409	63256409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:63256409G>A	ENST00000323865.3	-	1	1371	c.1138C>T	c.(1138-1140)Ctg>Ttg	p.L380L	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	380					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCGCCCAACAGGGTGGGCATG	0.527000													69	206					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115395442	115395442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:115395442G>A	ENST00000393780.3	+	3	1189	c.721G>A	c.(721-723)Gct>Act	p.A241T	GAP43_ENST00000305124.6_Missense_Mutation_p.A205T	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	205					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		GAGCAGCCAAGCTGAAGAGAA	0.607000													9	25					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46214590	46214590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46214590G>A	ENST00000371374.1	-	4	657	c.466C>T	c.(466-468)Ctc>Ttc	p.L156F	RCAN2_ENST00000330430.6_Missense_Mutation_p.L110F|RCAN2_ENST00000405162.1_Missense_Mutation_p.L156F|RCAN2_ENST00000306764.7_Missense_Mutation_p.L156F	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	110					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						GGCGAGATGAGAAACTGTTTG	0.522000													13	55					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26702046	26702046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26702046G>A	ENST00000529632.2	+	6	1646	c.1450G>A	c.(1450-1452)Gaa>Aaa	p.E484K	SEZ6L_ENST00000360929.3_Missense_Mutation_p.E484K|SEZ6L_ENST00000402979.1_Missense_Mutation_p.E257K|SEZ6L_ENST00000404234.3_Missense_Mutation_p.E484K|SEZ6L_ENST00000343706.4_Missense_Mutation_p.E484K|SEZ6L_ENST00000403121.1_Missense_Mutation_p.E257K|SEZ6L_ENST00000248933.6_Missense_Mutation_p.E484K	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	484	CUB 2.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CTGGACGATTGAAGCTCCAGA	0.552000													26	57					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270553	1270553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:1270553C>T	ENST00000348261.5	+	35	6869	c.6621C>T	c.(6619-6621)tcC>tcT	p.S2207S	CACNA1H_ENST00000565831.1_Silent_p.S2201S|CACNA1H_ENST00000358590.4_Silent_p.S2201S	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2207					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CGCGGCCCTCCGCGGCAGAGG	0.716000													18	26					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18624986	18624986	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:18624986C>T	ENST00000406451.3	+	3	255	c.105C>T	c.(103-105)ccC>ccT	p.P35P	HDAC9_ENST00000401921.1_Silent_p.P35P|HDAC9_ENST00000406072.1_Silent_p.P63P|HDAC9_ENST00000417496.2_Silent_p.P77P|HDAC9_ENST00000476135.1_3'UTR|HDAC9_ENST00000428307.2_Silent_p.P35P|HDAC9_ENST00000456174.2_Silent_p.P4P|HDAC9_ENST00000524023.1_Silent_p.P4P|HDAC9_ENST00000441542.2_Silent_p.P35P|HDAC9_ENST00000405010.3_Silent_p.P35P|HDAC9_ENST00000432645.2_Silent_p.P35P	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	35					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity	p.P35P(3)|p.P77P(1)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TGATGATGCCCGTGGTGGACC	0.483000													20	150					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	32483453	32483453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:32483453G>A	ENST00000359872.6	-	1	860	c.99C>T	c.(97-99)ttC>ttT	p.F33F		NM_001094.4	NP_001085.2	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	33					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	GCCCATACACGAAGATGTGGC	0.612000													11	16					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237279	56237279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56237279C>T	ENST00000312240.2	-	1	735	c.695G>A	c.(694-696)aGg>aAg	p.R232K		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					GGCCTTCTGCCTTCCTTCTGC	0.443000													27	72					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138738756	138738756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:138738756G>A	ENST00000329447.5	-	1	1012	c.748C>T	c.(748-750)Ctc>Ttc	p.L250F	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	250	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CGTTCCGGGAGCGGCGAGCGC	0.677000													9	21					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173873191	173873191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:173873191C>T	ENST00000367698.3	-	7	1349	c.1231G>A	c.(1231-1233)Ggc>Agc	p.G411S		NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	411					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GCTTCACTGCCTTCTTCATTT	0.468000													19	70					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241534449	241534449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241534449C>T	ENST00000391984.2	+	7	1202	c.1006C>T	c.(1006-1008)Ctc>Ttc	p.L336F	CAPN10_ENST00000404753.3_Missense_Mutation_p.L336F|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000354082.4_Missense_Mutation_p.L336F|CAPN10_ENST00000391982.2_Missense_Mutation_p.L336F|CAPN10_ENST00000352879.4_Intron	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	336	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		AGAGAGGCTGCTCTGCCATAC	0.637000													18	42					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28534796	28534796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:28534796C>T	ENST00000401766.2	-	12	2116	c.1604G>A	c.(1603-1605)tGg>tAg	p.W535*	SLC6A4_ENST00000261707.3_Nonsense_Mutation_p.W535*			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	535					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CCTCCAGAACCACCCCGGGCT	0.577000													5	41					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19766148	19766148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19766148G>A	ENST00000357324.6	-	11	1537	c.1511C>T	c.(1510-1512)tCc>tTc	p.S504F	ATP13A1_ENST00000496082.1_5'UTR|ATP13A1_ENST00000291503.5_Missense_Mutation_p.S386F	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	504					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGCGATGAGGGAGGTGTTGAC	0.637000													17	46					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197036339	197036339	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197036339G>A	ENST00000367412.1	-	1	58	c.15C>T	c.(13-15)aaC>aaT	p.N5N		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	5					blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TAAAAGTCAGGTTTTTCAACC	0.308000													15	39					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141890	29141890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:29141890C>T	ENST00000377167.2	+	1	580	c.478C>T	c.(478-480)Cat>Tat	p.H160Y		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H160D(1)		endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CTCAGCACTTCATTCCTCCTT	0.463000													32	265					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111470544	111470544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:111470544G>A	ENST00000265162.5	+	15	2536	c.2194G>A	c.(2194-2196)Gga>Aga	p.G732R		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	732					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AGATTCTCTGGGATGGAATGA	0.313000													16	76					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61778406	61778406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:61778406C>T	ENST00000423902.2	+	38	9387	c.8908C>T	c.(8908-8910)Ctc>Ttc	p.L2970F	CHD7_ENST00000524602.1_Missense_Mutation_p.L921F	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2970					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGAGTCCTCCCTCTTAGAAGA	0.488000													8	16					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73149058	73149058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:73149058C>T	ENST00000286657.4	-	22	3449	c.3413G>A	c.(3412-3414)gGa>gAa	p.G1138E		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	1138					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGTCTTACTTCCTGCTTGCTG	0.512000													47	88					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28273125	28273125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:28273125C>T	ENST00000305242.5	-	5	762	c.670G>A	c.(670-672)Gaa>Aaa	p.E224K	ARMC4_ENST00000239715.3_Missense_Mutation_p.E81K	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	224							binding	p.E224Q(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GAGGTATATTCAATAGATTCC	0.328000													45	106					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005808	74005808	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74005808C>T	ENST00000301607.3	-	22	3731	c.3478G>A	c.(3478-3480)Gag>Aag	p.E1160K	EVPL_ENST00000586740.1_Missense_Mutation_p.E1182K	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1160	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CTCTCCTCCTCGAGGAGGCTC	0.622000													19	39					0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55056065	55056065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:55056065G>A	ENST00000505374.1	+	4	257	c.165G>A	c.(163-165)atG>atA	p.M55I	DDX4_ENST00000514278.2_Missense_Mutation_p.M55I|DDX4_ENST00000354991.5_Missense_Mutation_p.M55I|DDX4_ENST00000508580.1_3'UTR|DDX4_ENST00000353507.5_Missense_Mutation_p.M55I|SLC38A9_ENST00000504880.1_Intron	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	55					multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				ATCATTTCATGAAAAGTGGAT	0.358000													41	95					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603410	5603410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5603410C>T	ENST00000423158.3	+	2	281	c.69C>T	c.(67-69)ctC>ctT	p.L23L	NTF3_ENST00000331010.6_Silent_p.L10L|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	10					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding	p.L10L(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						TGATATTTCTCGCTTATCTCC	0.433000													26	69					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72159743	72159743	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:72159743G>A	ENST00000438125.1	-	0	1053							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GTGGGCGGTCGATTTTCTTCA	0.388000													27	81					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43075811	43075811	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:43075811G>A	ENST00000267890.6	-	11	1111	c.1003C>T	c.(1003-1005)Cct>Tct	p.P335S	TTBK2_ENST00000567274.1_Missense_Mutation_p.P300S|TTBK2_ENST00000567840.1_Missense_Mutation_p.P335S	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	335					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AAGTCTCCAGGGATGGGAGTA	0.373000													83	191					0	0	1	0	0
TCF12	6938	broad.mit.edu	37	15	57523364	57523364	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57523364C>T	ENST00000537840.1	+	2	171	c.26C>T	c.(25-27)cCc>cTc	p.P9L	TCF12_ENST00000343827.3_Silent_p.S28S|TCF12_ENST00000560764.1_3'UTR|TCF12_ENST00000543579.1_Silent_p.S28S|TCF12_ENST00000333725.5_Silent_p.S198S|TCF12_ENST00000267811.5_Silent_p.S198S|TCF12_ENST00000557843.1_Silent_p.S198S|TCF12_ENST00000452095.2_Silent_p.S194S|TCF12_ENST00000438423.2_Silent_p.S198S			Q99081	HTF4_HUMAN	transcription factor 12	0					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATGCACCATCCCCAAATTCAG	0.343000			T	TEC	extraskeletal myxoid chondrosarcoma								46	125					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166848510	166848510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:166848510G>A	ENST00000423058.2	-	26	5292	c.5275C>T	c.(5275-5277)Cca>Tca	p.P1759S	SCN1A_ENST00000409050.1_Missense_Mutation_p.P1731S|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.P1748S|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.P1759S	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1759						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCAACAGATGGGTTCCCACAG	0.463000													87	223					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16276744	16276744	+	Missense_Mutation	SNP	C	C	T	rs72653780		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:16276744C>T	ENST00000205557.7	-	16	2016	c.1987G>A	c.(1987-1989)Ggt>Agt	p.G663S	ABCC6_ENST00000574094.1_Intron	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	663	ABC transporter 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCCACTGGACCGACAACAGCC	0.632000													25	71					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124766906	124766906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124766906C>T	ENST00000306534.3	-	2	807	c.322G>A	c.(322-324)Gac>Aac	p.D108N	ROBO4_ENST00000533054.1_5'UTR|ROBO4_ENST00000526899.1_5'UTR	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	108	Ig-like C2-type 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ACACCCAGGTCTGTGGACAGG	0.672000													12	29					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475273	140475273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140475273C>T	ENST00000194155.4	+	1	1047	c.899C>T	c.(898-900)tCg>tTg	p.S300L		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		300	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.S300*(1)		NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTGCAAAATCGGGAGAACTG	0.413000													38	73					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67303082	67303082	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:67303082A>T	ENST00000392676.3	-	6	636	c.572T>A	c.(571-573)gTt>gAt	p.V191D	ABCA5_ENST00000588877.1_Missense_Mutation_p.V191D|ABCA5_ENST00000392677.2_Missense_Mutation_p.V191D			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	191					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					CCAAAGAGAAACATTGGTCTT	0.343000													41	87					0	0	1	0	0
TMEM189	387521	broad.mit.edu	37	20	48760118	48760118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:48760118G>A	ENST00000557021.1	-	2	322	c.162C>T	c.(160-162)ttC>ttT	p.F54F	TMEM189_ENST00000371652.4_Silent_p.F54F|TMEM189-UBE2V1_ENST00000341698.2_Silent_p.F54F|TMEM189_ENST00000371650.5_Silent_p.F54F	NM_199203.2	NP_954673.1			transmembrane protein 189											breast(1)|endometrium(2)|large_intestine(3)|lung(2)	8			BRCA - Breast invasive adenocarcinoma(9;3.02e-07)			CGATGAGGCTGAAGCACAGGA	0.632000													11	14					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760054	115760054	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:115760054G>A	ENST00000427548.1	-	0	1759							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										TGCTGCGGCTGAAGGTTTTTC	0.403000													8	71					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402436	89402436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:89402436C>T	ENST00000439576.2	+	12	6994	c.6620C>T	c.(6619-6621)tCg>tTg	p.S2207L	ACAN_ENST00000352105.7_Missense_Mutation_p.S2207L|ACAN_ENST00000559004.1_Missense_Mutation_p.S2207L|ACAN_ENST00000561243.1_Missense_Mutation_p.S2207L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2207					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGTCACACCTCGCAGCTGGGC	0.592000													40	51					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177146484	177146484	+	Missense_Mutation	SNP	C	C	T	rs144171323		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:177146484C>T	ENST00000296525.3	-	2	318	c.205G>A	c.(205-207)Gca>Aca	p.A69T	ASB5_ENST00000512254.1_Missense_Mutation_p.A16T|ASB5_ENST00000511879.1_5'UTR	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	69					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		GATCGATCTGCCCAGGAACCT	0.343000													29	78					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73746301	73746301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:73746301G>A	ENST00000200181.3	+	28	3613	c.3426G>A	c.(3424-3426)aaG>aaA	p.K1142K	ITGB4_ENST00000449880.2_Silent_p.K1142K|ITGB4_ENST00000339591.3_Silent_p.K1142K|ITGB4_ENST00000450894.3_Silent_p.K1142K|ITGB4_ENST00000579662.1_Silent_p.K1142K	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1142	Fibronectin type-III 1.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity	p.K1142N(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGTCCAGGAAGATCCATTTCA	0.637000											OREG0024739	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	61					0	0	1	0	0
ZNF418	147686	broad.mit.edu	37	19	58439036	58439036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58439036G>A	ENST00000396147.1	-	4	804	c.513C>T	c.(511-513)agC>agT	p.S171S	ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000595830.1_Silent_p.S171S|ZNF418_ENST00000425570.3_Silent_p.S192S|ZNF418_ENST00000599852.1_Silent_p.S86S	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		GTAATCCTGAGCTGGGCAAAA	0.478000													34	70					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111540568	111540568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:111540568C>T	ENST00000428084.1	-	15	1614	c.1342G>A	c.(1342-1344)Gag>Aag	p.E448K	DOCK4_ENST00000476846.1_5'UTR|DOCK4_ENST00000437633.1_Missense_Mutation_p.E448K			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	448	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GCTGGTGGCTCCCCAGAGCCG	0.453000													9	19					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75136738	75136738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:75136738G>A	ENST00000356357.4	-	14	2215	c.1700C>T	c.(1699-1701)tCt>tTt	p.S567F	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		TCCTCCTAGAGAGGACTCATA	0.542000													9	113					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10427852	10427852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:10427852C>T	ENST00000245503.5	-	35	5490	c.5106G>A	c.(5104-5106)gaG>gaA	p.E1702E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Silent_p.E1702E|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1702					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTCTGCTCCTCTCTGTCTGTT	0.577000													43	62					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19480431	19480431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:19480431G>A	ENST00000375267.2	-	45	6464	c.6461C>T	c.(6460-6462)tCc>tTc	p.S2154F	UBR4_ENST00000375226.2_Missense_Mutation_p.S2154F|UBR4_ENST00000375254.3_Missense_Mutation_p.S2154F|UBR4_ENST00000375217.2_Missense_Mutation_p.S2154F			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2154					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCCACCATTGGAACTGCAGAC	0.493000													34	79					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102869433	102869433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102869433C>T	ENST00000456098.1	-	2	426	c.208G>A	c.(208-210)Ggc>Agc	p.G70S	IGF1_ENST00000392904.1_Missense_Mutation_p.G70S|IGF1_ENST00000424202.2_Missense_Mutation_p.G54S|IGF1_ENST00000307046.8_Missense_Mutation_p.G70S|IGF1_ENST00000337514.6_Missense_Mutation_p.G70S	NM_001111283.1	NP_001104753.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	70	B.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						AAATAAAAGCCCCTGTCTCCA	0.547000													15	61					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52282435	52282435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52282435G>A	ENST00000301190.6	+	2	456	c.229G>A	c.(229-231)Gac>Aac	p.D77N	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_5'UTR|ANKRD33_ENST00000538991.1_5'UTR	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	0										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GAGACGGCTGGACATGTCTGA	0.597000													9	80					0	0	1	0	0
FBXO32	114907	broad.mit.edu	37	8	124553147	124553147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124553147G>A	ENST00000517956.1	-	1	299	c.108C>T	c.(106-108)gaC>gaT	p.D36D	FBXO32_ENST00000443022.2_Silent_p.D36D	NM_058229.3|NM_148177.2	NP_478136.1|NP_680482.1	Q969P5	FBX32_HUMAN	F-box protein 32	36										autonomic_ganglia(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)|stomach(1)	21	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ACCTGCTGAGGTCGCTCACGA	0.687000													11	25					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	141888811	141888811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:141888811C>T	ENST00000420921.2	-	3	366	c.278G>A	c.(277-279)aGg>aAg	p.R93K	RNF150_ENST00000515673.1_Missense_Mutation_p.R234K|RNF150_ENST00000515057.1_5'UTR|RNF150_ENST00000507500.1_Missense_Mutation_p.R234K|RNF150_ENST00000379512.2_Missense_Mutation_p.R93K|RNF150_ENST00000306799.3_Intron			Q9ULK6	RN150_HUMAN	ring finger protein 150	234	PA.					integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					ATATCGAAACCTCTGGATGTA	0.378000													30	66					0	0	1	0	0
GNAI2	2771	broad.mit.edu	37	3	50293694	50293694	+	Missense_Mutation	SNP	C	C	T	rs137853226		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50293694C>T	ENST00000313601.6	+	5	919	c.535C>T	c.(535-537)Cgc>Tgc	p.R179C	GNAI2_ENST00000491100.1_3'UTR|GNAI2_ENST00000451956.1_Missense_Mutation_p.R142C|GNAI2_ENST00000266027.5_Missense_Mutation_p.R163C|GNAI2_ENST00000536647.1_Missense_Mutation_p.R98C|GNAI2_ENST00000440628.1_Missense_Mutation_p.R127C|GNAI2_ENST00000422163.1_Missense_Mutation_p.R163C	NM_002070.2	NP_002061.1	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	179					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|liver(2)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		GCTACGGACCCGCGTAAAGAC	0.592000													17	41					0	0	1	0	0
CABS1	85438	broad.mit.edu	37	4	71201257	71201257	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71201257G>A	ENST00000273936.4	+	1	560	c.501G>A	c.(499-501)aaG>aaA	p.K167K		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	167						flagellum	calcium ion binding	p.K167K(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GCACACTAAAGGACAGCAGTG	0.433000													16	49					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127797571	127797571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:127797571C>T	ENST00000556132.1	-	6	2464	c.1600G>A	c.(1600-1602)Gaa>Aaa	p.E534K	SOGA3_ENST00000368268.2_Missense_Mutation_p.E534K|SOGA3_ENST00000525778.1_Missense_Mutation_p.E534K|SOGA3_ENST00000481848.2_Missense_Mutation_p.E534K|SOGA3_ENST00000465909.2_Missense_Mutation_p.E534K	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	534						integral to membrane											GCGGCTTCTTCCTTAACAAAC	0.403000													34	61					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153655048	153655048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:153655048G>A	ENST00000368680.3	+	5	1718	c.1246G>A	c.(1246-1248)Gag>Aag	p.E416K		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	416					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TATGGATCCCGAGAATGGTGC	0.527000													13	49					0	0	1	0	0
INPP5B	3633	broad.mit.edu	37	1	38330034	38330034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:38330034C>T	ENST00000373023.2	-	23	2909	c.2816G>A	c.(2815-2817)cGa>cAa	p.R939Q	INPP5B_ENST00000373026.1_Missense_Mutation_p.R939Q|INPP5B_ENST00000373027.1_Missense_Mutation_p.R695Q|INPP5B_ENST00000373024.3_Missense_Mutation_p.R859Q	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	939	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CAGCAGTTCTCGCAAAAACGC	0.398000													5	44					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54784340	54784340	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54784340G>A	ENST00000391748.1	-	2	139	c.12C>T	c.(10-12)atC>atT	p.I4I	LILRB2_ENST00000391746.1_Silent_p.I4I|LILRB2_ENST00000314446.5_Silent_p.I4I|LILRB2_ENST00000434421.1_5'UTR|LILRB2_ENST00000391749.4_Silent_p.I4I	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	4					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGACTGTGACGATGGGGGTCA	0.587000													56	144					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71128715	71128715	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71128715C>T	ENST00000299213.8	-	2	400	c.330G>A	c.(328-330)gaG>gaA	p.E110E		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	110	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						AGGCGTCCTTCTCCAGGTTTT	0.483000													90	107					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110420301	110420301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110420301G>A	ENST00000378402.5	+	18	1941	c.1837G>A	c.(1837-1839)Gaa>Aaa	p.E613K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	613					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCTTGGTTATGAAGTAGTTGA	0.328000										HNSCC(38;0.096)			16	27					0	0	1	0	0
TBX6	6911	broad.mit.edu	37	16	30100386	30100386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30100386G>A	ENST00000553607.1	-	3	1192	c.499C>T	c.(499-501)Cgc>Tgc	p.R167C	TBX6_ENST00000395224.2_Missense_Mutation_p.R167C|TBX6_ENST00000279386.2_Missense_Mutation_p.R167C			O95947	TBX6_HUMAN	T-box 6	167					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						TCAGGCAGGCGGGGCTCTGCC	0.632000													9	85					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175365684	175365684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:175365684G>A	ENST00000367674.1	-	5	1944	c.1236C>T	c.(1234-1236)gcC>gcT	p.A412A	TNR_ENST00000263525.2_Silent_p.A412A	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	412	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACGTACGGGTGGCCACCTTGG	0.502000													23	60					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248731	20248731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20248731G>A	ENST00000315957.4	+	1	331	c.250G>A	c.(250-252)Gac>Aac	p.D84N		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AATGCTCATAGACTTCTTTGT	0.443000													109	276					0	0	1	0	0
NFX1	4799	broad.mit.edu	37	9	33294597	33294597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:33294597C>T	ENST00000379540.3	+	2	267	c.205C>T	c.(205-207)Cat>Tat	p.H69Y	NFX1_ENST00000318524.6_Missense_Mutation_p.H69Y|NFX1_ENST00000379521.4_Missense_Mutation_p.H69Y	NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	69					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		CTCTGCTGTTCATCAGCATAG	0.458000													45	154					0	0	1	0	0
MYL4	4635	broad.mit.edu	37	17	45299116	45299116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:45299116G>A	ENST00000354968.1	+	5	510	c.382G>A	c.(382-384)Gag>Aag	p.E128K	MYL4_ENST00000393450.1_Missense_Mutation_p.E128K|MYL4_ENST00000572316.1_Missense_Mutation_p.E128K	NM_001002841.1	NP_001002841.1	P12829	MYL4_HUMAN	myosin, light chain 4, alkali; atrial, embryonic	128					cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			endometrium(2)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)	11						CCGCAACAAGGAGCAGGGCAC	0.542000													42	57					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82580687	82580687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:82580687C>T	ENST00000423517.2	-	6	9554	c.9217G>A	c.(9217-9219)Gga>Aga	p.G3073R	PCLO_ENST00000333891.8_Missense_Mutation_p.G3073R	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3004					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TACTGGGGTCCTGGTGGTGGT	0.463000													5	8					0	0	1	0	0
USP50	373509	broad.mit.edu	37	15	50833302	50833302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:50833302C>T	ENST00000532404.1	-	4	777	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	USP50_ENST00000530218.1_Intron	NM_203494.4	NP_987090.2	E9PP86	E9PP86_HUMAN	ubiquitin specific peptidase 50	202					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(5)	13				all cancers(107;0.000519)|GBM - Glioblastoma multiforme(94;0.00288)		GTGAAGACTTCGTTCTTGTAG	0.443000													15	36					0	0	1	0	0
GCG	2641	broad.mit.edu	37	2	163003880	163003880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:163003880C>T	ENST00000418842.2	-	3	491	c.237G>A	c.(235-237)atG>atA	p.M79I	GCG_ENST00000375497.3_Missense_Mutation_p.M79I	NM_002054.4	NP_002045.1	P01275	GLUC_HUMAN	glucagon	79					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(9)	14					Exenatide(DB01276)|Phentolamine(DB00692)	TCTTGGTATTCATCAACCACT	0.413000													68	181					0	0	1	0	0
UCP3	7352	broad.mit.edu	37	11	73715533	73715533	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:73715533G>A	ENST00000314032.4	-	5	1191	c.639C>T	c.(637-639)ctC>ctT	p.L213L	UCP3_ENST00000426995.2_Silent_p.L213L|UCP3_ENST00000348534.4_Intron	NM_003356.3	NP_003347.1	P55916	UCP3_HUMAN	uncoupling protein 3 (mitochondrial, proton carrier)	213					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	12	Breast(11;2.08e-05)					CCTCACCAGTGAGCAGGTGGT	0.582000													16	56					0	0	1	0	0
MAP7D2	256714	broad.mit.edu	37	X	20034416	20034416	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:20034416C>T	ENST00000379651.3	-	10	1335	c.1317G>A	c.(1315-1317)aaG>aaA	p.K439K	MAP7D2_ENST00000543767.1_Silent_p.K324K|MAP7D2_ENST00000452324.3_Silent_p.K387K|MAP7D2_ENST00000443379.3_Silent_p.K394K|MAP7D2_ENST00000379643.5_Silent_p.K480K	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	439										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						cctcctctgcctttcttttca	0.463000													14	10					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55080462	55080462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:55080462C>T	ENST00000302250.2	-	4	646	c.486G>A	c.(484-486)gaG>gaA	p.E162E	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Silent_p.E162E	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	162						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTTTGCCTTCCTCTGTCAGCT	0.557000													15	49					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327383	52327383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52327383C>T	ENST00000339223.4	+	2	561	c.382C>T	c.(382-384)Ctg>Ttg	p.L128L	FPR3_ENST00000595991.1_Silent_p.L128L	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	128					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TATTTGTGTCCTGCATCCAGC	0.468000													31	63					0	0	1	0	0
FOXN4	121643	broad.mit.edu	37	12	109723224	109723224	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:109723224G>A	ENST00000299162.5	-	8	890	c.786C>T	c.(784-786)tcC>tcT	p.S262S	FOXN4_ENST00000355216.1_Silent_p.S82S	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	262					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						AGCCCTTGCGGGAGGAGCCGC	0.602000													19	53					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56436006	56436006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56436006C>T	ENST00000588751.1	-	3	431	c.407G>A	c.(406-408)gGa>gAa	p.G136E	NLRP13_ENST00000342929.3_Missense_Mutation_p.G136E			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	136							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ATCTTGGCATCCCTGGGTCTG	0.433000													32	90					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617754	111617754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:111617754G>A	ENST00000374667.3	-	1	1485	c.457C>T	c.(457-459)Ccg>Tcg	p.P153S		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	153						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						GGGCTGAGCGGAGGGTCGGAG	0.622000													9	42					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79254511	79254511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79254511C>T	ENST00000419573.3	-	28	4071	c.3797G>A	c.(3796-3798)cGa>cAa	p.R1266Q	RASGRF1_ENST00000558480.2_Missense_Mutation_p.R1250Q|RASGRF1_ENST00000394745.3_Missense_Mutation_p.R482Q	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1268	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TGGTTCTATTCGGAGAGAAGA	0.463000													6	23					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24164462	24164462	+	Silent	SNP	G	G	A	rs144206187	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:24164462G>A	ENST00000396671.2	-	11	1647	c.1299C>T	c.(1297-1299)gcC>gcT	p.A433A	THRB_ENST00000280696.5_Silent_p.A448A|THRB_ENST00000356447.4_Silent_p.A433A|THRB_ENST00000416420.1_Silent_p.A433A	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	433	Interaction with NR2F6.|Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGGCATGGCAGGCTCCTATCA	0.498000													63	133					0	0	1	0	0
CNTFR	1271	broad.mit.edu	37	9	34557641	34557641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:34557641G>A	ENST00000378980.3	-	6	780	c.487C>T	c.(487-489)Cgc>Tgc	p.R163C	CNTFR_ENST00000351266.4_Missense_Mutation_p.R163C	NM_001207011.1|NM_147164.2	NP_001193940.1|NP_671693.1	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	163	Fibronectin type-III 1.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(4)|skin(1)	15	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		ATGTGGCAGCGGTTCTTGAGG	0.537000													24	62					0	0	1	0	0
NREP	9315	broad.mit.edu	37	5	111066648	111066648	+	Silent	SNP	G	G	A	rs11556173		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:111066648G>A	ENST00000379671.3	-	5	441	c.177C>T	c.(175-177)tcC>tcT	p.S59S	NREP_ENST00000509979.1_3'UTR|NREP_ENST00000509427.1_Silent_p.S59S|NREP_ENST00000515855.1_3'UTR|NREP_ENST00000509025.1_Intron|STARD4-AS1_ENST00000500779.2_RNA|NREP_ENST00000419114.2_Silent_p.S59S|STARD4-AS1_ENST00000513221.1_RNA|NREP_ENST00000507742.1_5'UTR|NREP_ENST00000450761.2_Silent_p.S59S|NREP_ENST00000257435.7_Silent_p.S59S|NREP_ENST00000455559.2_Silent_p.S59S|NREP_ENST00000447165.2_Silent_p.S59S|NREP_ENST00000508870.1_Silent_p.S59S|NREP_ENST00000446294.2_Silent_p.S59S|NREP_ENST00000453526.2_Silent_p.S59S|NREP_ENST00000395634.3_Silent_p.S103S	NM_001142478.1	NP_001135950.1	Q16612	NP311_HUMAN	neuronal regeneration related protein	59						cytoplasm											TGATTCTTGGGGAGCGGAGTT	0.463000													20	107					0	0	1	0	0
STARD6	147323	broad.mit.edu	37	18	51863599	51863599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:51863599G>A	ENST00000581310.1	-	6	536	c.163C>T	c.(163-165)Cca>Tca	p.P55S	STARD6_ENST00000580990.2_5'UTR|STARD6_ENST00000307844.3_Missense_Mutation_p.P55S			P59095	STAR6_HUMAN	StAR-related lipid transfer (START) domain containing 6	55	START.				lipid transport		lipid binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)	8				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		GGTGATTCTGGAATTATCCCT	0.313000													21	64					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90347765	90347765	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:90347765G>C	ENST00000300060.6	-	5	1294	c.981C>G	c.(979-981)ttC>ttG	p.F327L		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	327	Interaction with HCoV-229E.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GACCAGCAAAGAAGTTAAGGA	0.597000													10	140					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57351663	57351663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57351663G>A	ENST00000361249.3	+	7	1015	c.919G>A	c.(919-921)Gac>Aac	p.D307N		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	307	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GAGGAAGGATGACATTATGCT	0.403000													21	66					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77377374	77377374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:77377374C>T	ENST00000451710.3	-	26	4450	c.4213G>A	c.(4213-4215)Gaa>Aaa	p.E1405K	TRPM6_ENST00000376864.4_Missense_Mutation_p.E1405K|TRPM6_ENST00000361255.3_Missense_Mutation_p.E1400K|TRPM6_ENST00000360774.1_Missense_Mutation_p.E1405K|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000449912.2_Missense_Mutation_p.E1400K			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1405					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity	p.E1405K(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TCGTGCTTTTCCTTGGGTTCA	0.512000													25	61					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74018548	74018548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:74018548G>A	ENST00000301607.3	-	5	805	c.552C>T	c.(550-552)atC>atT	p.I184I	EVPL_ENST00000586740.1_Silent_p.I184I	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	184	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CCTTCTGCAGGATGTTGTGCT	0.682000													8	29					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467511	74467511	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:74467511C>T	ENST00000249842.3	+	2	669	c.312C>T	c.(310-312)gaC>gaT	p.D104D	ISLR_ENST00000395118.1_Silent_p.D104D|RP11-665J16.1_ENST00000561647.1_RNA	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	104					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						AGAGCCTGGACCTCAGCCACA	0.607000													21	64					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155098568	155098568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:155098568G>A	ENST00000392825.3	+	5	904	c.337G>A	c.(337-339)Gaa>Aaa	p.E113K	GALNT13_ENST00000409237.1_Missense_Mutation_p.E113K	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	113						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						CTACCCTGATGAACTTCCAAA	0.333000													24	41					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56565064	56565064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56565064G>A	ENST00000390649.3	+	13	3189	c.3189G>A	c.(3187-3189)agG>agA	p.R1063R		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1063						mitochondrion|nucleolus	ATP binding	p.R1063R(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGATCTCGAGGAGCAGACACC	0.572000													13	41					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51411827	51411827	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:51411827T>G	ENST00000319760.6	-	1	621	c.569A>C	c.(568-570)tAc>tCc	p.Y190S		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				GCCTATAAAGTAGGTGTCAGT	0.423000													15	44					0	0	1	0	0
CKMT2	1160	broad.mit.edu	37	5	80550833	80550833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:80550833G>A	ENST00000424301.2	+	6	707	c.469G>A	c.(469-471)Gag>Aag	p.E157K	CTC-281B15.1_ENST00000500148.2_RNA|CTC-281B15.1_ENST00000501927.2_RNA|CKMT2_ENST00000254035.4_Missense_Mutation_p.E157K|CTC-281B15.1_ENST00000511495.1_RNA|CTC-281B15.1_ENST00000502041.2_RNA|CTC-281B15.1_ENST00000505295.1_RNA|CKMT2_ENST00000437669.1_Missense_Mutation_p.E157K|CTC-281B15.1_ENST00000503483.2_RNA|CTC-281B15.1_ENST00000512287.1_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	157					creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	GCAGTTCGACGAGCATTACGT	0.637000													31	63					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131521956	131521956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131521956G>A	ENST00000423981.1	+	2	2421	c.2311G>A	c.(2311-2313)Gag>Aag	p.E771K	AMER3_ENST00000321420.4_Missense_Mutation_p.E771K	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GGCCTCTGTGGAGGACCAGCC	0.677000													8	19					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36342177	36342177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:36342177G>A	ENST00000378910.5	-	3	383	c.384C>T	c.(382-384)atC>atT	p.I128I	NPHS1_ENST00000353632.6_Silent_p.I128I	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	128	Ig-like C2-type 1.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGATGGAGAGGATCACTCTGG	0.642000													17	36					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777046	18777046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:18777046C>T	ENST00000380548.4	+	19	3158	c.2819C>T	c.(2818-2820)tCg>tTg	p.S940L		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	940	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CTCAAGCCCTCGGATGCAGGC	0.652000													12	82					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177249815	177249815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:177249815C>T	ENST00000361539.4	+	8	1815	c.1503C>T	c.(1501-1503)aaC>aaT	p.N501N	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		501						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CCCTGGAAAACTTTCTTGGGC	0.577000													15	73					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29782870	29782870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:29782870G>A	ENST00000269202.6	+	6	312	c.265G>A	c.(265-267)Gga>Aga	p.G89R	MEP1B_ENST00000581447.1_Missense_Mutation_p.G89R	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	89	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GAATGCTAAGGGAGTTATCCT	0.363000													5	19					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135744367	135744367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:135744367G>A	ENST00000375845.3	-	7	2105	c.2075C>T	c.(2074-2076)cCa>cTa	p.P692L	MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000358371.4_Missense_Mutation_p.P579L|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392915.1_Missense_Mutation_p.P709L	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		TCTGCCTGATGGAGCCGAACA	0.418000													81	173					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238045810	238045810	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:238045810A>T	ENST00000366570.4	-	12	1693	c.1535T>A	c.(1534-1536)cTt>cAt	p.L512H	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	512					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGTCCCAGAAAGGCCTGCCAC	0.453000													48	116					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25861613	25861613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:25861613G>A	ENST00000376351.3	+	7	1909	c.1550G>A	c.(1549-1551)cGa>cAa	p.R517Q		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	517						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						ACGGCTCAACGAATTCCATAT	0.408000													24	143					0	0	1	0	0
CCNYL2	414194	broad.mit.edu	37	10	42928724	42928724	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:42928724G>A	ENST00000483242.3	-	0	776					NR_103829.1				cyclin Y-like 2											breast(2)|endometrium(1)|lung(3)|ovary(1)	7						ATTGTAAGATGAGGCTGGCTG	0.393000													29	58					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75069974	75069974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:75069974C>T	ENST00000310715.3	-	13	1528	c.1408G>A	c.(1408-1410)Gaa>Aaa	p.E470K	TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000401621.2_Missense_Mutation_p.E470K|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000394865.1_Missense_Mutation_p.E470K	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	470							binding	p.E470K(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					AGCTGAATTTCCAACACAATG	0.348000													49	124					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70080324	70080324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:70080324C>T	ENST00000446444.1	-	1	125	c.117G>A	c.(115-117)atG>atA	p.M39I	RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	39					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						GGATTGTCTTCATATTCATCC	0.443000													99	259					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065373	35065373	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35065373C>T	ENST00000382002.5	-	10	2113	c.1687G>A	c.(1687-1689)Gat>Aat	p.D563N	PRLR_ENST00000511486.1_Missense_Mutation_p.D462N|PRLR_ENST00000310101.5_3'UTR|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.D462N|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	563					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GCATGTGGATCTGGCACCAAC	0.517000													12	55					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54517740	54517740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:54517740G>A	ENST00000566473.2	+	8	972	c.972G>A	c.(970-972)atG>atA	p.M324I	ANKFN1_ENST00000318698.2_Missense_Mutation_p.M324I			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	324	Fibronectin type-III.									NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						AAATCATCATGGATAATCTGC	0.448000													19	58					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123456259	123456259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123456259C>T	ENST00000360772.3	-	9	1098	c.720G>A	c.(718-720)ggG>ggA	p.G240G	MYLK_ENST00000360304.3_Silent_p.G240G|MYLK_ENST00000475616.1_Silent_p.G240G|MYLK_ENST00000346322.5_Silent_p.G240G|MYLK_ENST00000359169.1_Silent_p.G240G			Q15746	MYLK_HUMAN	myosin light chain kinase	240	Ig-like C2-type 2.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCGAGGCCTTCCCCGACCCGT	0.567000													55	106					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26085934	26085934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:26085934C>T	ENST00000313735.6	-	26	3560	c.3327G>A	c.(3325-3327)caG>caA	p.Q1109Q		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	1109					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGTCCTCGACCTGCTCCTCAT	0.607000													9	12					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179720250	179720250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179720250C>T	ENST00000420890.2	-	19	3001	c.2884G>A	c.(2884-2886)Gaa>Aaa	p.E962K	CCDC141_ENST00000295723.5_Missense_Mutation_p.E387K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	387							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CTAACTTTTTCCATTTTCCTT	0.284000													10	33					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113519003	113519003	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:113519003G>A	ENST00000297405.5	-	29	5056	c.4812C>T	c.(4810-4812)ttC>ttT	p.F1604F	CSMD3_ENST00000455883.2_Silent_p.F1500F|CSMD3_ENST00000343508.3_Silent_p.F1564F|CSMD3_ENST00000352409.3_Silent_p.F1604F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1604	CUB 9.					integral to membrane|plasma membrane		p.F1564L(1)|p.F1604L(1)|p.F1604_P1605>LA(1)|p.F1564_P1565>LA(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATGGATGAGGGAAGTTTGGTG	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	70					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7647019	7647019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7647019C>T	ENST00000299492.4	+	8	1111	c.723C>T	c.(721-723)gcC>gcT	p.A241A	PPFIBP2_ENST00000533792.1_Silent_p.A83A|PPFIBP2_ENST00000528883.1_Silent_p.A129A|PPFIBP2_ENST00000530181.1_Silent_p.A98A	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	241					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CTGAAGTCGCCCAGCTGCAAG	0.562000													20	48					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68598372	68598372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68598372C>T	ENST00000570495.1	+	5	1974	c.1682C>T	c.(1681-1683)gCc>gTc	p.A561V	ZFP90_ENST00000563169.2_Missense_Mutation_p.A561V|ZFP90_ENST00000398253.2_Missense_Mutation_p.A561V|RP11-615I2.7_ENST00000571720.1_RNA			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	561					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		TGTGGGAAAGCCTTTAGTCAA	0.438000													29	118					0	0	1	0	0
SPAG8	26206	broad.mit.edu	37	9	35811403	35811403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35811403G>A	ENST00000340291.2	-	2	764	c.640C>T	c.(640-642)Cct>Tct	p.P214S	SPAG8_ENST00000396638.2_Missense_Mutation_p.P214S|SPAG8_ENST00000479751.1_5'UTR|SPAG8_ENST00000484764.1_Missense_Mutation_p.P212S	NM_172312.1	NP_758516.1	Q99932	SPAG8_HUMAN	sperm associated antigen 8	214						acrosomal vesicle|membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			AACCCTGGAGGAATACAGGGG	0.597000													25	118					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42113041	42113041	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42113041C>T	ENST00000457542.2	+	23	2779	c.2493C>T	c.(2491-2493)tcC>tcT	p.S831S	MAPKBP1_ENST00000514566.1_Silent_p.S831S|MAPKBP1_ENST00000260357.7_Silent_p.S670S|MAPKBP1_ENST00000221214.6_Silent_p.S714S|MAPKBP1_ENST00000456763.2_Silent_p.S837S	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	837										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CACAGGAGTCCGTGGGGTTCC	0.572000													11	25					0	0	1	0	0
WDR63	126820	broad.mit.edu	37	1	85570255	85570255	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:85570255C>T	ENST00000294664.6	+	14	1708	c.1528C>T	c.(1528-1530)Caa>Taa	p.Q510*	WDR63_ENST00000326813.8_Nonsense_Mutation_p.Q471*|WDR63_ENST00000370596.1_Nonsense_Mutation_p.Q471*	NM_145172.3	NP_660155.2	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	510										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)	36				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		AATATGCTGTCAACTTGTCAC	0.328000													14	47					0	0	1	0	0
LIPG	9388	broad.mit.edu	37	18	47091816	47091816	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:47091816A>T	ENST00000261292.4	+	2	505	c.227A>T	c.(226-228)gAc>gTc	p.D76V	LIPG_ENST00000580036.1_Missense_Mutation_p.D76V|LIPG_ENST00000577628.1_Missense_Mutation_p.D112V|LIPG_ENST00000427224.2_Missense_Mutation_p.D76V	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	76					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						CCCTTAGAAGACTGCAGTTTC	0.517000													18	60					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189020234	189020234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:189020234C>T	ENST00000512729.1	-	4	800	c.426G>A	c.(424-426)gtG>gtA	p.V142V	TRIML2_ENST00000536972.1_Silent_p.V192V|TRIML2_ENST00000326754.3_Silent_p.V142V	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	142							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TCTCAAGCTCCACGATGAGCT	0.478000													30	90					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76502909	76502909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76502909C>T	ENST00000389840.5	-	30	4808	c.4684G>A	c.(4684-4686)Gct>Act	p.A1562T	DNAH17_ENST00000585328.1_Missense_Mutation_p.A1563T					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCTGCCAAAGCCTTTTCACAG	0.542000													40	103					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103202396	103202396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:103202396G>A	ENST00000424685.2	-	35	5374	c.5215C>T	c.(5215-5217)Ccc>Tcc	p.P1739S	RELN_ENST00000343529.5_Missense_Mutation_p.P1739S|RELN_ENST00000428762.1_Missense_Mutation_p.P1739S			P78509	RELN_HUMAN	reelin	1739					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CGGGTCCTGGGAGAACTAACC	0.433000													7	16					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220500079	220500079	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220500079C>T	ENST00000358055.3	+	13	2345	c.1833C>T	c.(1831-1833)atC>atT	p.I611I	SLC4A3_ENST00000373762.3_Silent_p.I638I|SLC4A3_ENST00000273063.6_Silent_p.I638I|SLC4A3_ENST00000373760.2_Silent_p.I611I|SLC4A3_ENST00000317151.3_Silent_p.I611I			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	611					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCATTGTGATCCCCCCGTCCG	0.612000													25	60					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61669557	61669557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:61669557C>T	ENST00000381103.2	+	18	2115	c.1630C>T	c.(1630-1632)Cgt>Tgt	p.R544C	KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000506857.1_Missense_Mutation_p.R518C|KIF2A_ENST00000407818.3_Missense_Mutation_p.R602C|KIF2A_ENST00000401507.3_Missense_Mutation_p.R564C	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	564	Kinesin-motor.				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		TGGTGATGTTCGTCCAATAAT	0.418000													9	41					0	0	1	0	0
PACSIN1	29993	broad.mit.edu	37	6	34497596	34497596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:34497596C>T	ENST00000538621.1	+	6	1011	c.766C>T	c.(766-768)Ctc>Ttc	p.L256F	PACSIN1_ENST00000374043.2_Missense_Mutation_p.L214F|PACSIN1_ENST00000244458.2_Missense_Mutation_p.L256F	NM_001199583.1	NP_001186512.1	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in neurons 1	256					endocytosis		protein kinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	13						CAAACGGCACCTCAACCTGGC	0.582000													6	14					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110452971	110452971	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:110452971T>C	ENST00000378402.5	+	33	4093	c.3989T>C	c.(3988-3990)tTa>tCa	p.L1330S		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1330	IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAGTATGTTTTAGAAGTGACC	0.363000										HNSCC(38;0.096)			28	103					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348929	220348929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:220348929C>T	ENST00000312358.7	+	30	6876	c.6744C>T	c.(6742-6744)atC>atT	p.I2248I	SPEG_ENST00000485813.1_3'UTR|AC053503.11_ENST00000429882.1_RNA	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2248	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ATGCTCAGATCATTCAGTCCC	0.687000													32	47					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422971	26422971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:26422971C>T	ENST00000335473.7	+	43	7281	c.7031C>T	c.(7030-7032)tCg>tTg	p.S2344L	MYO18B_ENST00000536101.1_Missense_Mutation_p.S2344L|MYO18B_ENST00000407587.2_Missense_Mutation_p.S2345L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2344				KS -> LT (in Ref. 5).		nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCCGAAAAGTCGAAAACCCAA	0.557000													22	91					0	0	1	0	0
SHKBP1	92799	broad.mit.edu	37	19	41083492	41083492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:41083492C>T	ENST00000291842.5	+	4	265	c.216C>T	c.(214-216)ttC>ttT	p.F72F	SHKBP1_ENST00000600733.1_Silent_p.F72F	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	72	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTACAGTCTTCGCCCCCATCC	0.577000													92	195					0	0	1	0	0
MYO6	4646	broad.mit.edu	37	6	76576248	76576248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:76576248C>T	ENST00000369981.3	+	17	1959	c.1680C>T	c.(1678-1680)ccC>ccT	p.P560P	MYO6_ENST00000369975.1_Silent_p.P560P|MYO6_ENST00000369977.3_Silent_p.P560P|MYO6_ENST00000369985.4_Silent_p.P560P			Q9UM54	MYO6_HUMAN	myosin VI	560	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		TTCAGATTCCCAGAAAATCTA	0.323000													6	76					0	0	1	0	0
SH2D7	646892	broad.mit.edu	37	15	78393354	78393354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:78393354G>A	ENST00000328828.5	+	5	759	c.759G>A	c.(757-759)cgG>cgA	p.R253R	SH2D7_ENST00000409568.2_Silent_p.R117R	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	253										endometrium(2)|kidney(2)|lung(3)	7						ACCAGGCACGGCTAGGCTTGG	0.607000													17	56					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120730	94120730	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:94120730C>T	ENST00000369303.4	-	3	505	c.321G>A	c.(319-321)agG>agA	p.R107R	EPHA7_ENST00000369297.1_Silent_p.R107R	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	107						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGTTACAATCCCTCAGGGTGA	0.408000													32	58					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50315887	50315887	+	Missense_Mutation	SNP	G	G	A	rs11554413		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:50315887G>A	ENST00000332853.3	-	2	232	c.209C>T	c.(208-210)tCc>tTc	p.S70F	VSTM4_ENST00000298454.3_Missense_Mutation_p.S70F	NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	70	Ig-like.					integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						GGCCTCCTGGGAGTCGAAGGA	0.612000													24	58					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107600912	107600912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107600912G>A	ENST00000393561.1	-	16	2548	c.2364C>T	c.(2362-2364)gcC>gcT	p.A788A	LAMB1_ENST00000222399.6_Silent_p.A764A|LAMB1_ENST00000393560.1_Silent_p.A764A			P07942	LAMB1_HUMAN	laminin, beta 1	764	Laminin EGF-like 6.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTAACAGGGCAGAAATGC	0.488000													5	70					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25023491	25023491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:25023491C>T	ENST00000400382.1	+	12	1868	c.1113C>T	c.(1111-1113)ccC>ccT	p.P371P	GGT1_ENST00000400380.1_Silent_p.P371P|GGT1_ENST00000404532.1_Silent_p.P27P|GGT1_ENST00000466310.1_3'UTR|GGT1_ENST00000400383.1_Silent_p.P371P|GGT1_ENST00000248923.4_Silent_p.P371P|GGT1_ENST00000403838.1_Silent_p.P27P|GGT1_ENST00000406383.2_Silent_p.P371P|GGT1_ENST00000404920.1_Silent_p.P27P|GGT1_ENST00000404223.1_Silent_p.P27P|GGT1_ENST00000401885.1_Silent_p.P27P			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	371					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding	p.P371P(1)		breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	ACTACAAGCCCGAGTTCTACA	0.622000													17	23					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14724464	14724464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:14724464G>A	ENST00000253697.3	+	3	696	c.244G>A	c.(244-246)Gaa>Aaa	p.E82K	C3orf20_ENST00000435614.1_Intron|C3orf20_ENST00000412910.1_Intron	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	82						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GGTGCTCATGGAACCCACCTT	0.607000													14	43					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189859501	189859501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:189859501G>A	ENST00000304636.3	+	20	1569	c.1399G>A	c.(1399-1401)Gat>Aat	p.D467N	COL3A1_ENST00000317840.5_Missense_Mutation_p.D467N	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	467	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AGATGGCAAGGATGGATCACC	0.443000													21	69					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45895188	45895188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:45895188G>A	ENST00000418234.2	-	8	1843	c.1765C>T	c.(1765-1767)Cca>Tca	p.P589S	PPP1R13L_ENST00000360957.5_Missense_Mutation_p.P589S	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	589	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GCCGGGGGTGGAATGGGAGCT	0.667000													21	34					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56127844	56127844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:56127844G>A	ENST00000303039.3	+	1	154	c.122G>A	c.(121-123)gGg>gAg	p.G41E		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					ACCATGGCAGGGAACCTGGGC	0.493000													48	122					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150932882	150932882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:150932882G>A	ENST00000261800.5	-	5	4024	c.4012C>T	c.(4012-4014)Cct>Tct	p.P1338S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1338	Cadherin 11.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding	p.P1338S(1)		NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGGGGCCAAGGGATCCACTCA	0.567000													14	50					0	0	1	0	0
TMEM5	10329	broad.mit.edu	37	12	64202844	64202844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:64202844G>A	ENST00000537373.1	+	6	1472	c.524G>A	c.(523-525)aGc>aAc	p.S175N	TMEM5-AS1_ENST00000546214.1_RNA|TMEM5_ENST00000261234.6_Missense_Mutation_p.S435N	NM_001278237.1	NP_001265166.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	435						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		ATTTTAGAAAGCTCATTTTTA	0.249000													8	34					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88967948	88967948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:88967948C>T	ENST00000268679.4	-	2	664	c.268G>A	c.(268-270)Ggg>Agg	p.G90R	CBFA2T3_ENST00000360302.2_Missense_Mutation_p.G29R|CBFA2T3_ENST00000448839.1_Intron|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.G29R|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.G90R	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	90	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).|Pro-rich.|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CGTGTGGCCCCCTGGGATGCG	0.687000			T	RUNX1	AML								11	32					0	0	1	0	0
NR1H3	10062	broad.mit.edu	37	11	47283522	47283522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47283522C>T	ENST00000467728.1	+	6	2179	c.941C>T	c.(940-942)aCc>aTc	p.T314I	NR1H3_ENST00000407404.1_Missense_Mutation_p.T254I|NR1H3_ENST00000527949.1_Missense_Mutation_p.T163I|NR1H3_ENST00000405853.3_Missense_Mutation_p.T254I|NR1H3_ENST00000481889.2_Missense_Mutation_p.T333I|NR1H3_ENST00000441012.2_Missense_Mutation_p.T314I|NR1H3_ENST00000395397.3_Missense_Mutation_p.T269I|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000405576.1_Missense_Mutation_p.T209I			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	314	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						GAGAGTATCACCTTCCTCAAG	0.507000													66	92					0	0	1	0	0
ZNF713	349075	broad.mit.edu	37	7	55990881	55990881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55990881C>T	ENST00000429591.2	+	2	113	c.75C>T	c.(73-75)gcC>gcT	p.A25A	MRPS17_ENST00000426595.1_Silent_p.A25A|ZNF713_ENST00000482436.1_3'UTR	NM_182633.1	NP_872439.1	Q8N859	ZN713_HUMAN	zinc finger protein 713	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGGATGTGGCCGTGGACTTCA	0.517000													34	58					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186954305	186954305	+	Missense_Mutation	SNP	C	C	T	rs148975558		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186954305C>T	ENST00000296280.6	-	11	1579	c.1354G>A	c.(1354-1356)Ggg>Agg	p.G452R	MASP1_ENST00000495249.1_Intron|MASP1_ENST00000392472.2_Missense_Mutation_p.G339R|MASP1_ENST00000337774.5_Intron	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	451	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TTTCGGCCCCCAATGATCCTC	0.592000													18	183					0	0	1	0	0
IL6	3569	broad.mit.edu	37	7	22767223	22767223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:22767223C>T	ENST00000404625.1	+	3	639	c.180C>T	c.(178-180)atC>atT	p.I60I	IL6_ENST00000407492.1_Intron|IL6_ENST00000401630.3_Silent_p.I37I|IL6_ENST00000406575.1_Silent_p.I60I|IL6_ENST00000258743.5_Silent_p.I60I|AC073072.5_ENST00000325042.2_RNA|IL6_ENST00000420258.2_Silent_p.I114I|IL6_ENST00000401651.1_Intron			P05231	IL6_HUMAN	interleukin 6 (interferon, beta 2)	60					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)	8					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	TTCGGTACATCCTCGACGGCA	0.592000													23	55					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36158063	36158063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36158063C>T	ENST00000400445.3	+	46	7598	c.7064C>T	c.(7063-7065)gCt>gTt	p.A2355V	NBEA_ENST00000310336.4_Missense_Mutation_p.A2355V|NBEA_ENST00000537702.1_Missense_Mutation_p.A148V|NBEA_ENST00000540320.1_Missense_Mutation_p.A2355V|NBEA_ENST00000379939.2_Missense_Mutation_p.A2352V	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2355	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CCCAAGAGAGCTGTGTTTTAT	0.333000													21	92					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124750348	124750348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124750348C>T	ENST00000397801.1	+	27	4185	c.3993C>T	c.(3991-3993)ttC>ttT	p.F1331F	ROBO3_ENST00000525482.1_3'UTR|ROBO3_ENST00000538940.1_Silent_p.F1309F|ROBO3_ENST00000543966.1_Silent_p.F94F	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1331					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GACCAAGCTTCCTGTCCCGGG	0.662000													7	21					0	0	1	0	0
CD5	921	broad.mit.edu	37	11	60886927	60886927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60886927G>A	ENST00000347785.3	+	5	851	c.685G>A	c.(685-687)Gaa>Aaa	p.E229K		NM_014207.3	NP_055022.2	P06127	CD5_HUMAN	CD5 molecule	229	SRCR 2.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		GGAGCCACGGGAACACCAGCC	0.557000													20	56					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35753829	35753829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35753829G>A	ENST00000440995.2	+	24	3419	c.3419G>A	c.(3418-3420)gGa>gAa	p.G1140E	SPEF2_ENST00000356031.3_Missense_Mutation_p.G1145E|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1145					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GACACTCTTGGAATGACAATG	0.512000													30	155					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21074807	21074807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:21074807C>T	ENST00000377122.4	-	28	3310	c.2914G>A	c.(2914-2916)Gag>Aag	p.E972K	NEBL_ENST00000417816.2_Missense_Mutation_p.E228K|NEBL_ENST00000377159.4_Missense_Mutation_p.E194K	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	972	SH3.				regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AAGGAGACCTCGTCTTCATCC	0.502000													50	52					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057962	9057962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9057962G>A	ENST00000397910.4	-	3	29687	c.29484C>T	c.(29482-29484)tcC>tcT	p.S9828S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9830	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTAGGACAGAGGAATGAGATT	0.458000													26	67					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782698	54782698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:54782698G>A	ENST00000391748.1	-	6	1051	c.924C>T	c.(922-924)gcC>gcT	p.A308A	LILRB2_ENST00000391746.1_Silent_p.A308A|LILRB2_ENST00000314446.5_Silent_p.A308A|LILRB2_ENST00000434421.1_Silent_p.A192A|LILRB2_ENST00000391749.4_Silent_p.A308A	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	308	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTCGCTGGGGGCCGAGCACT	0.647000													24	21					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111061284	111061284	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:111061284C>T	ENST00000369771.2	-	1	513	c.126G>A	c.(124-126)ggG>ggA	p.G42G		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	42						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		AGGAGCTGCCCCCAGGCCGGC	0.557000													18	37					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100141898	100141898	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:100141898C>T	ENST00000524871.1	+	18	2529	c.2239C>T	c.(2239-2241)Cga>Tga	p.R747*	CNTN5_ENST00000527185.1_Nonsense_Mutation_p.R747*|CNTN5_ENST00000528682.1_Nonsense_Mutation_p.R747*|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Nonsense_Mutation_p.R747*|CNTN5_ENST00000418526.2_Nonsense_Mutation_p.R673*	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	747	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ATATGAATTTCGAGTGGTAGC	0.458000													20	53					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102709877	102709877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102709877C>T	ENST00000299855.5	-	7	1289	c.1033G>A	c.(1033-1035)Gaa>Aaa	p.E345K		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	345	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CTAGTAACTTCATATGCGGCA	0.388000													36	103					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112534	57112534	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:57112534G>A	ENST00000454682.1	-	3	3061	c.2780C>T	c.(2779-2781)cCt>cTt	p.P927L	NACA_ENST00000548563.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						GATTCCTTTAGGGGCTGGAGT	0.612000			T	BCL6	NHL								15	32					0	0	1	0	0
U66061.31	0	broad.mit.edu	37	7	142423748	142423748	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142423748G>A	ENST00000506718.1	+	0	756																											GCAAGAACAAGGAGACTCCTC	0.552000													7	21					0	0	1	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32975359	32975359	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:32975359C>T	ENST00000229829.5	-	3	417	c.342G>A	c.(340-342)cgG>cgA	p.R114R	HLA-DOA_ENST00000450833.2_Silent_p.R84R|HLA-DOA_ENST00000495532.1_5'UTR	NM_002119.3	NP_002110.1	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO alpha	114	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	9						GCACGGTCACCCGTGGAGGCA	0.597000													46	86					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424093	125424093	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:125424093C>T	ENST00000373686.1	+	1	249	c.249C>T	c.(247-249)ccC>ccT	p.P83P				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TGTTCCTCCCCATCTACCTTA	0.493000													9	74					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231112699	231112699	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231112699G>A	ENST00000392045.3	+	8	925	c.811G>A	c.(811-813)Gag>Aag	p.E271K	SP140_ENST00000417495.3_Intron|SP140_ENST00000486687.2_Intron|SP140_ENST00000420434.3_Missense_Mutation_p.E271K|SP140_ENST00000350136.5_Intron|SP140_ENST00000343805.6_Missense_Mutation_p.E245K	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	271					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GAAACAGGGAGAGGAGGAAGG	0.488000													23	121					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104081828	104081828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104081828G>A	ENST00000265148.3	-	21	2329	c.2240C>T	c.(2239-2241)tCa>tTa	p.S747L	CENPE_ENST00000380026.3_Missense_Mutation_p.S722L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	747					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTCAATTCTGAAAGCAAAAT	0.323000													13	94					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41303402	41303402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:41303402C>T	ENST00000347132.5	+	13	1893	c.1811C>T	c.(1810-1812)cCc>cTc	p.P604L	KCNQ4_ENST00000509682.2_Missense_Mutation_p.P550L|KCNQ4_ENST00000506017.1_3'UTR	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	604	A-domain (Tetramerization).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			GACAAGGGGCCCTCCGACGCG	0.647000													7	18					0	0	1	0	0
ZNF736	728927	broad.mit.edu	37	7	63796756	63796756	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:63796756C>T	ENST00000355095.4	+	3	445	c.123C>T	c.(121-123)gtC>gtT	p.V41V	ZNF736_ENST00000423484.1_Silent_p.V41V	NM_001170905.1	NP_001164376.1	B4DX44	ZN736_HUMAN	zinc finger protein 736	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|stomach(1)|urinary_tract(1)	9						GAAACCTGGTCTCCTTGGGTG	0.383000													15	52					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833351	24833351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:24833351C>T	ENST00000376451.2	+	14	4461	c.4201C>T	c.(4201-4203)Ccg>Tcg	p.P1401S	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000376454.3_Missense_Mutation_p.P1718S|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000396446.1_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1718					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTTGCTAGTTCCGGATGAAGG	0.512000													25	41					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114293996	114293996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:114293996G>A	ENST00000393500.3	+	16	1793	c.973G>A	c.(973-975)Gaa>Aaa	p.E325K	FOXP2_ENST00000390668.3_Missense_Mutation_p.E424K|FOXP2_ENST00000403559.4_Missense_Mutation_p.E417K|FOXP2_ENST00000393494.2_Missense_Mutation_p.E400K|FOXP2_ENST00000393498.2_Missense_Mutation_p.E379K|FOXP2_ENST00000360232.4_Missense_Mutation_p.E400K|FOXP2_ENST00000408937.3_Missense_Mutation_p.E425K|FOXP2_ENST00000393489.3_Missense_Mutation_p.E308K|FOXP2_ENST00000393491.3_Missense_Mutation_p.E308K|FOXP2_ENST00000350908.4_Missense_Mutation_p.E400K			O15409	FOXP2_HUMAN	forkhead box P2	400					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						TAAAGAACGCGAACGTCTTCA	0.393000													43	111					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47765425	47765425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:47765425G>A	ENST00000273857.4	-	4	587	c.588C>T	c.(586-588)ttC>ttT	p.F196F	CORIN_ENST00000504584.1_Silent_p.F196F|CORIN_ENST00000502252.1_Silent_p.F129F|CORIN_ENST00000505909.1_Silent_p.F196F|CORIN_ENST00000508498.1_Silent_p.F57F	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	196	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TGCACTCAGGGAAGGCGAGGG	0.413000													8	26					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46148504	46148504	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:46148504A>G	ENST00000344646.5	-	3	403	c.188T>C	c.(187-189)aTt>aCt	p.I63T	ZFAND4_ENST00000374366.3_5'UTR|ZFAND4_ENST00000335258.7_Missense_Mutation_p.I63T|ZFAND4_ENST00000374371.2_Missense_Mutation_p.I63T	NM_001128324.1|NM_174890.2	NP_001121796.1|NP_777550.2	Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	63	Ubiquitin-like.						zinc ion binding										ACAGATGGGAATACCTTAAGG	0.303000													22	71					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348807	140348807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140348807C>T	ENST00000289269.5	+	1	2988	c.2456C>T	c.(2455-2457)cCt>cTt	p.P819L	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		819					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCAGGGCCTTCGGGAGCC	0.522000													15	57					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754281	49754281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49754281G>A	ENST00000304801.3	-	1	772	c.620C>T	c.(619-621)cCc>cTc	p.P207L		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	207					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					AGCCAGAAAGGGTCTCACTGG	0.433000													46	132					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42584550	42584550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42584550C>T	ENST00000600245.1	+	2	2447	c.1792C>T	c.(1792-1794)Cgc>Tgc	p.R598C	ZNF574_ENST00000359044.4_Missense_Mutation_p.R598C|ZNF574_ENST00000222339.7_Missense_Mutation_p.R688C			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				GCTCATGCACCGCTACCATCA	0.622000													12	39					0	0	1	0	0
MAB21L1	4081	broad.mit.edu	37	13	36049679	36049679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:36049679C>T	ENST00000379919.4	-	1	1153	c.597G>A	c.(595-597)cgG>cgA	p.R199R	NBEA_ENST00000310336.4_Intron|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000540320.1_Intron|NBEA_ENST00000379939.2_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	199					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CCTCCGCCACCCGGTTGGGTC	0.652000													16	73					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131921984	131921984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131921984G>A	ENST00000286355.5	-	6	3702	c.1610C>T	c.(1609-1611)gCa>gTa	p.A537V	ADCY8_ENST00000377928.3_Missense_Mutation_p.A537V	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	537					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GAGTTTGTTTGCAATATCCAC	0.468000										HNSCC(32;0.087)			85	157					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84537235	84537235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:84537235C>T	ENST00000262753.4	-	16	1883	c.1738G>A	c.(1738-1740)Gag>Aag	p.E580K	POF1B_ENST00000373145.3_Missense_Mutation_p.E580K	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	580							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TCTGTTTTCTCAATCACAATA	0.368000													16	14					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116037787	116037787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116037787C>T	ENST00000603594.1	+	7	1002	c.681C>T	c.(679-681)atC>atT	p.I227I	VWA2_ENST00000392982.3_Silent_p.I227I	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	227						extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GCTCGGCCATCTGCTCCAGCG	0.647000													4	35					0	0	1	0	0
DLL3	10683	broad.mit.edu	37	19	39994806	39994806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:39994806G>A	ENST00000205143.4	+	5	755	c.748G>A	c.(748-750)Gtc>Atc	p.V250I	DLL3_ENST00000356433.5_Missense_Mutation_p.V250I	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	250					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCTCTGCACGGTCCCTGTCTC	0.667000													22	44					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57411647	57411647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:57411647G>A	ENST00000543257.1	-	8	1362	c.796C>T	c.(796-798)Ctt>Ttt	p.L266F	C8B_ENST00000371237.4_Missense_Mutation_p.L318F|C8B_ENST00000535057.1_Missense_Mutation_p.L256F	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	318	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ACTCTCTGAAGGAACTCGTAA	0.483000													25	50					0	0	1	0	0
EME1	146956	broad.mit.edu	37	17	48457688	48457688	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48457688A>C	ENST00000393271.2	+	8	1483	c.1401A>C	c.(1399-1401)gaA>gaC	p.E467D	EME1_ENST00000511648.2_Missense_Mutation_p.E467D|EME1_ENST00000338165.4_Missense_Mutation_p.E454D	NM_001166131.1	NP_001159603.1	Q96AY2	EME1_HUMAN	essential meiotic structure-specific endonuclease 1	454					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding			endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	19	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			TCCGAGATGAAACTACCTTCT	0.547000								Direct reversal of damage;Homologous recombination					3	26					0	0	1	0	0
RPL4	6124	broad.mit.edu	37	15	66795836	66795836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:66795836G>A	ENST00000307961.6	-	2	127	c.35C>T	c.(34-36)tCc>tTc	p.S12F	RPL4_ENST00000568588.1_5'UTR	NM_000968.3	NP_000959.2	P36578	RL4_HUMAN	ribosomal protein L4	12					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)|urinary_tract(1)	17						CCCCTTTTCGGAGTACACCGA	0.428000													14	57					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36899114	36899114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:36899114C>T	ENST00000301807.6	-	12	2214	c.317G>A	c.(316-318)gGa>gAa	p.G106E	TRANK1_ENST00000429976.2_Missense_Mutation_p.G656E|TRANK1_ENST00000428977.2_Missense_Mutation_p.G106E	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	656					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GACTGCACTTCCTTCAGGCAG	0.582000													17	67					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82815175	82815175	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82815175G>A	ENST00000265077.3	+	7	1615	c.1050G>A	c.(1048-1050)gaG>gaA	p.E350E	VCAN_ENST00000512590.2_Silent_p.E302E|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Silent_p.E350E	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	350	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TAGCTAAAGAGGCTACAACCA	0.373000													35	80					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37363342	37363342	+	Missense_Mutation	SNP	C	C	T	rs113898889		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:37363342C>T	ENST00000361924.2	+	13	2040	c.1666C>T	c.(1666-1668)Cgg>Tgg	p.R556W	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.R578W	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	556	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding	p.R556W(1)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						AAATAAACTTCGGGACCTTCA	0.348000													33	60					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32137827	32137827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:32137827C>T	ENST00000312561.4	+	4	4352	c.3938C>T	c.(3937-3939)tCt>tTt	p.S1313F	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		ATGACAGCATCTTATGAACAA	0.348000													16	77					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4217164	4217164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:4217164C>T	ENST00000600132.1	+	18	2283	c.2007C>T	c.(2005-2007)acC>acT	p.T669T	ANKRD24_ENST00000262970.5_Silent_p.T759T|ANKRD24_ENST00000318934.4_Silent_p.T669T	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	669										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TCACAGGGACCACAAACATGG	0.617000													5	12					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887946	9887946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:9887946C>T	ENST00000306084.6	+	2	1669	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F	TXNDC2_ENST00000357775.4_Silent_p.F423F|TXNDC2_ENST00000577697.1_3'UTR|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	490	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GACCATTCTTCCATGCCCTGT	0.587000													8	38					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140251067	140251067	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140251067T>C	ENST00000398640.2	+	1	2379	c.2379T>C	c.(2377-2379)aaT>aaC	p.N793N	PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGGTCAAATCACCCCGGAC	0.463000													3	15					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34166234	34166234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34166234C>T	ENST00000373381.4	-	23	3792	c.3616G>A	c.(3616-3618)Gtt>Att	p.V1206I	CSMD2_ENST00000373380.1_Missense_Mutation_p.V79I|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1166	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGCTAAAAACTCCCAGCAAA	0.498000													45	95					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33873829	33873829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33873829C>T	ENST00000389232.4	+	14	1628	c.1558C>T	c.(1558-1560)Ctc>Ttc	p.L520F	RYR3_ENST00000415757.3_Missense_Mutation_p.L520F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	520					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCTGAACCTCCTCTACAAATT	0.448000													24	75					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48309146	48309146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:48309146C>T	ENST00000297423.4	+	6	1120	c.736C>T	c.(736-738)Ccc>Tcc	p.P246S	SPIDR_ENST00000541342.1_Missense_Mutation_p.P176S|SPIDR_ENST00000521214.1_3'UTR|SPIDR_ENST00000518074.1_Missense_Mutation_p.P186S	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		AGCTAAGTTTCCCAGGACTCC	0.353000													80	181					0	0	1	0	0
CRTAM	56253	broad.mit.edu	37	11	122720888	122720888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:122720888C>T	ENST00000227348.4	+	2	206	c.159C>T	c.(157-159)ccC>ccT	p.P53P		NM_019604.2	NP_062550.2	O95727	CRTAM_HUMAN	cytotoxic and regulatory T cell molecule	53	Ig-like V-type.				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		GGCTGACCCCCTCAGGGTTCA	0.483000													24	81					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754690	49754690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49754690G>A	ENST00000304801.3	-	1	363	c.211C>T	c.(211-213)Ccc>Tcc	p.P71S		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	71					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TCAGGCATGGGAACACCATCA	0.502000													21	102					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32232418	32232418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:32232418C>T	ENST00000346541.3	+	12	2318	c.1781C>T	c.(1780-1782)gCt>gTt	p.A594V	CBFA2T2_ENST00000375279.2_Missense_Mutation_p.A594V|CBFA2T2_ENST00000359606.3_Missense_Mutation_p.A604V|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.A565V|CBFA2T2_ENST00000342704.5_Missense_Mutation_p.A585V|CBFA2T2_ENST00000543126.1_Missense_Mutation_p.A142V	NM_005093.3	NP_005084.1	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	594						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						TCAACACCTGCTTCTGTGACA	0.627000													28	139					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1957858	1957858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:1957858G>A	ENST00000382895.3	+	17	3255	c.2824G>A	c.(2824-2826)Ggg>Agg	p.G942R	WHSC1_ENST00000382891.5_Missense_Mutation_p.G942R|WHSC1_ENST00000382892.2_Missense_Mutation_p.G942R|WHSC1_ENST00000382888.3_Missense_Mutation_p.G290R|WHSC1_ENST00000508803.1_Missense_Mutation_p.G942R|WHSC1_ENST00000482415.2_3'UTR	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	942	PWWP 2.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GTACATGGAGGGGGACCGGGG	0.512000			T	IGH@	MM								95	230					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098833	11098833	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:11098833G>A	ENST00000470054.1	-	0	92									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		agagcgagacgagccacggtg	0.612000													6	54					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35792664	35792664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35792664C>T	ENST00000342694.2	+	1	514	c.259C>T	c.(259-261)Ctc>Ttc	p.L87F		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	87					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CGCTGTGGACCTCAAGCTGTA	0.662000													34	101					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113447007	113447007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113447007G>A	ENST00000392583.2	+	10	2218	c.2011G>A	c.(2011-2013)Gat>Aat	p.D671N	OAS2_ENST00000342315.4_Missense_Mutation_p.D671N|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	671	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding	p.D671N(1)		NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CTGCTTCAAGGATGGGACTGG	0.512000													69	208					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118221228	118221228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:118221228C>T	ENST00000402510.2	-	11	3964	c.3965G>A	c.(3964-3966)aGg>aAg	p.R1322K		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	1322										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TTTAGAATTCCTCCACTCTTT	0.488000													49	157					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48318381	48318381	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:48318381G>A	ENST00000435803.1	+	18	7614	c.7590G>A	c.(7588-7590)aaG>aaA	p.K2530K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2530					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AGCTGGTCAAGAAAGTTTCGG	0.413000													69	158					0	0	1	0	0
NAT6	24142	broad.mit.edu	37	3	50334222	50334222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:50334222G>A	ENST00000443842.1	-	2	1480	c.673C>T	c.(673-675)Cca>Tca	p.P225S	HYAL3_ENST00000415204.1_Intron|HYAL3_ENST00000359051.3_Intron|HYAL3_ENST00000336307.1_Intron|NAT6_ENST00000443094.2_Missense_Mutation_p.P225S|NAT6_ENST00000354862.4_Missense_Mutation_p.P247S|NAT6_ENST00000417393.1_Missense_Mutation_p.P225S|HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000450982.1_Intron					N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GTCAGGTTTGGGGCCTTCCTG	0.662000													20	42					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131848526	131848526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:131848526C>T	ENST00000286355.5	-	12	4764	c.2672G>A	c.(2671-2673)gGa>gAa	p.G891E	ADCY8_ENST00000377928.3_Missense_Mutation_p.G760E	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	891					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CACTTACTCTCCACTGTGGTT	0.502000										HNSCC(32;0.087)			10	63					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10434093	10434093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10434093G>A	ENST00000293677.6	-	4	1038	c.957C>T	c.(955-957)ccC>ccT	p.P319P		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	302	Interaction with PTBP1 (By similarity).					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			TACTGCGGCCGGGGGGCCCAG	0.716000													4	20					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12445349	12445349	+	Missense_Mutation	SNP	C	C	T	rs147684777		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12445349C>T	ENST00000358136.3	+	59	11531	c.11401C>T	c.(11401-11403)Cgt>Tgt	p.R3801C	VPS13D_ENST00000356315.4_Missense_Mutation_p.R3776C|VPS13D_ENST00000496628.1_3'UTR	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3800					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GAAAAGCAGCCGTTCATATGA	0.393000													5	66					0	0	1	0	0
FLYWCH1	84256	broad.mit.edu	37	16	2988351	2988351	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:2988351C>T	ENST00000399667.2	+	10	2454	c.2091C>T	c.(2089-2091)caC>caT	p.H697H	FLYWCH1_ENST00000416288.2_Silent_p.H647H|FLYWCH1_ENST00000253928.9_Silent_p.H648H|FLYWCH1_ENST00000570752.1_3'UTR			Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1	648						nucleus	DNA binding|metal ion binding			kidney(1)|lung(3)	4						CCCAGGGCCACCGCATCATGG	0.682000													8	17					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87041247	87041247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:87041247G>A	ENST00000265723.4	-	23	2997	c.2886C>T	c.(2884-2886)ctC>ctT	p.L962L	ABCB4_ENST00000359206.3_Silent_p.L962L|ABCB4_ENST00000545634.1_Silent_p.L962L|ABCB4_ENST00000358400.3_Intron|ABCB4_ENST00000453593.1_Intron	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	962	ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CATTCACAATGAGATATGCAC	0.323000													22	55					0	0	1	0	0
DUS2	54920	broad.mit.edu	37	16	68110572	68110572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:68110572C>T	ENST00000565263.1	+	15	1614	c.1120C>T	c.(1120-1122)Cta>Tta	p.L374L	DUS2L_ENST00000432752.1_Silent_p.L339L|DUS2L_ENST00000358896.6_Silent_p.L374L	NM_017803.3	NP_060273.1	Q9NX74	DUS2L_HUMAN		374	DRBM.				tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|stomach(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		TAAGATGTGCCTACTAGAGTG	0.607000													21	88					0	0	1	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44364864	44364864	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44364864C>T	ENST00000262915.3	+	9	870	c.693C>T	c.(691-693)atC>atT	p.I231I	ST3GAL3_ENST00000335430.6_Silent_p.I146I|ST3GAL3_ENST00000372362.2_Intron|ST3GAL3_ENST00000531993.1_Silent_p.I146I|ST3GAL3_ENST00000347631.2_Silent_p.I177I|ST3GAL3_ENST00000361746.4_Silent_p.I231I|ST3GAL3_ENST00000332628.6_Silent_p.I131I|ST3GAL3_ENST00000353126.3_Silent_p.I162I|ST3GAL3_ENST00000372365.1_Silent_p.I162I|ST3GAL3_ENST00000372366.1_Silent_p.I161I|ST3GAL3_ENST00000533933.1_Silent_p.I162I|ST3GAL3_ENST00000531451.1_Intron|ST3GAL3_ENST00000372367.1_Silent_p.I161I|ST3GAL3_ENST00000372372.2_Silent_p.I200I|ST3GAL3_ENST00000531816.1_Intron|ST3GAL3_ENST00000372377.4_Intron|ST3GAL3_ENST00000361812.4_Intron|ST3GAL3_ENST00000330208.2_Intron|ST3GAL3_ENST00000545417.1_Intron|ST3GAL3_ENST00000372368.2_Silent_p.I216I|ST3GAL3_ENST00000351035.3_Silent_p.I200I|ST3GAL3_ENST00000372369.1_Silent_p.I162I|ST3GAL3_ENST00000361400.4_Silent_p.I146I|ST3GAL3_ENST00000361392.4_Silent_p.I162I|ST3GAL3_ENST00000528371.1_Silent_p.I146I|ST3GAL3_ENST00000372374.2_Silent_p.I131I|ST3GAL3_ENST00000461375.1_3'UTR|ST3GAL3_ENST00000372375.2_Silent_p.I216I	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	162					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				GCTGCATCATCGTGGGCAATG	0.592000													24	75					0	0	1	0	0
POLL	27343	broad.mit.edu	37	10	103345861	103345861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103345861G>A	ENST00000370162.3	-	3	662	c.168C>T	c.(166-168)gcC>gcT	p.A56A	POLL_ENST00000370172.1_5'UTR|POLL_ENST00000370158.3_Intron|POLL_ENST00000299206.4_Silent_p.A56A|DPCD_ENST00000416979.2_Intron|POLL_ENST00000436284.2_5'UTR|POLL_ENST00000456836.2_Intron|POLL_ENST00000370169.1_Silent_p.A56A|DPCD_ENST00000470165.1_Intron|POLL_ENST00000339310.3_Intron	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	56	BRCT.				DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GTTCTGCCCGGGCTCGTCCAA	0.537000								DNA polymerases (catalytic subunits)					18	45					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160901448	160901448	+	Silent	SNP	G	G	A	rs147284017	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:160901448G>A	ENST00000283243.7	-	2	536	c.330C>T	c.(328-330)ctC>ctT	p.L110L	PLA2R1_ENST00000392771.1_Silent_p.L110L	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	110	Ricin B-type lectin.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GTAAGGAAACGAGGGTGGAGT	0.542000													28	77					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739639	15739639	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:15739639C>T	ENST00000441682.2	+	0	1444							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						TTATTCCTTTCTCGGCGGGGC	0.597000													28	85					0	0	1	0	0
SYS1	90196	broad.mit.edu	37	20	43995655	43995655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:43995655C>T	ENST00000243918.5	+	4	662	c.371C>T	c.(370-372)gCc>gTc	p.A124V	SYS1-DBNDD2_ENST00000475242.1_Intron|SYS1-DBNDD2_ENST00000452133.1_Intron|SYS1_ENST00000426004.1_Intron|SYS1_ENST00000414310.1_Missense_Mutation_p.A103V|SYS1_ENST00000372727.1_Missense_Mutation_p.A124V|SYS1_ENST00000479779.1_3'UTR	NM_033542.3	NP_291020.1	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)	124					protein transport	Golgi membrane|integral to membrane				cervix(1)|endometrium(2)|large_intestine(2)|prostate(1)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				CTGGTCCAAGCCGTGTGCATT	0.562000													20	103					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7329881	7329881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:7329881C>T	ENST00000574034.1	+	3	281	c.233C>T	c.(232-234)cCt>cTt	p.P78L	C17orf74_ENST00000333870.3_Silent_p.L191L|RP11-104H15.7_ENST00000575310.1_RNA			Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	0						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				GGAGGACAACCTGCCCTTCCC	0.602000													53	59					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11532847	11532847	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:11532847G>A	ENST00000262442.3	+	7	1532	c.1464G>A	c.(1462-1464)gaG>gaA	p.E488E	DNAH9_ENST00000579406.1_3'UTR|DNAH9_ENST00000454412.2_Silent_p.E488E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	488	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AATTTCAAGAGATGTACAGGC	0.557000													33	47					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28607230	28607230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:28607230C>T	ENST00000253063.3	+	10	1681	c.1360C>T	c.(1360-1362)Cac>Tac	p.H454Y		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	454					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCCAGGTCCACGTGAACTT	0.612000													13	66					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1104238	1104238	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:1104238C>T	ENST00000441003.2	+	49	8456	c.8429C>T	c.(8428-8430)tCc>tTc	p.S2810F		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	5172						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GCCCGGCGCTCCCCTAGGCAT	0.706000													4	21					0	0	1	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75557688	75557688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75557688G>A	ENST00000300576.5	+	9	682	c.682G>A	c.(682-684)Gag>Aag	p.E228K		NM_001164404.1	NP_001157876.1	A6NDK9	GOG6C_HUMAN	golgin A6 family, member C	228										ovary(1)	1						AGTCCAGCTAGAGCGGGACGA	0.552000													62	458					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99625472	99625472	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:99625472C>T	ENST00000370597.3	-	15	2175		c.e15-1		GOLGA7B_ENST00000370602.1_3'UTR|CRTAC1_ENST00000298819.4_Splice_Site	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1							proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CCGAGAGTCCCTGTAGGGAGG	0.692000													6	11					0	0	1	0	0
ZNF33A	7581	broad.mit.edu	37	10	38345344	38345344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:38345344C>T	ENST00000374618.3	+	5	2470	c.2292C>T	c.(2290-2292)ctC>ctT	p.L764L	ZNF33A_ENST00000432900.2_Silent_p.L770L|ZNF33A_ENST00000469037.2_Intron|ZNF33A_ENST00000458705.2_Silent_p.L763L|ZNF33A_ENST00000307441.9_Silent_p.L763L	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	763						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						AGTCAAATCTCATTGTACATC	0.383000													30	90					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756965	71756965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:71756965G>A	ENST00000318442.5	-	2	849	c.359C>T	c.(358-360)cCg>cTg	p.P120L		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CTTGGGGCGCGGGGGCTGCGG	0.582000													74	188					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350066	30350066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:30350066G>A	ENST00000359358.4	-	2	927	c.489C>T	c.(487-489)atC>atT	p.I163I	KLHL14_ENST00000358095.4_Silent_p.I163I|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	163						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GGATGTGCAGGATCTTGCTGA	0.622000													19	89					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509476	71509476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71509476G>A	ENST00000396073.3	+	9	2614	c.2333G>A	c.(2332-2334)aGa>aAa	p.R778K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	778					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			CAGAGAGAAAGAAGGCCGTAT	0.473000													25	72					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67680152	67680152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:67680152G>A	ENST00000334583.6	+	5	641	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	RLTPR_ENST00000545661.1_Missense_Mutation_p.E105K	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	105										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGCCGCCCTGGAACAGCTGGC	0.637000													15	22					0	0	1	0	0
C2orf50	130813	broad.mit.edu	37	2	11284107	11284107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:11284107C>T	ENST00000381585.3	+	3	641	c.359C>T	c.(358-360)cCc>cTc	p.P120L	C2orf50_ENST00000405022.3_Missense_Mutation_p.P120L			Q96LR7	CB050_HUMAN	chromosome 2 open reading frame 50	120										breast(1)|large_intestine(1)|upper_aerodigestive_tract(1)	3	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0997)|OV - Ovarian serous cystadenocarcinoma(76;0.134)		GACACAGTTCCCAGTTCCACG	0.582000													19	71					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54275341	54275341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:54275341G>A	ENST00000354646.2	-	17	3878	c.3440C>T	c.(3439-3441)tCc>tTc	p.S1147F	WNK3_ENST00000375159.2_Missense_Mutation_p.S1147F|WNK3_ENST00000375169.3_Missense_Mutation_p.S1147F	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1147					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						TTCAGCAGAGGAAGAAAATGG	0.438000													40	53					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060279	54060279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:54060279G>A	ENST00000312233.2	-	3	863	c.297C>T	c.(295-297)acC>acT	p.T99T		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	99					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						CATTTACACAGGTGACCAGAG	0.677000													23	41					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42880695	42880695	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:42880695C>T	ENST00000334370.4	+	41	8740	c.8105C>T	c.(8104-8106)aCt>aTt	p.T2702I	MEGF8_ENST00000378073.4_Missense_Mutation_p.T363I|MEGF8_ENST00000251268.6_Missense_Mutation_p.T2769I	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2769						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GGGCCCATCACTCTCGAGCCC	0.721000													3	5					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40357655	40357655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40357655C>T	ENST00000221347.6	-	34	15665	c.15658G>A	c.(15658-15660)Gag>Aag	p.E5220K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5220						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCTTGACCTCACATACACGG	0.637000													23	53					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871098	51871098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:51871098C>T	ENST00000371497.5	+	2	1988	c.1101C>T	c.(1099-1101)agC>agT	p.S367S	TSHZ2_ENST00000603338.2_Silent_p.S364S|TSHZ2_ENST00000329613.6_Silent_p.S364S	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	367					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			ATGGAGCCAGCTACACCTGGC	0.502000													30	73					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231035380	231035380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:231035380C>T	ENST00000258381.6	-	18	2062	c.1985G>A	c.(1984-1986)cGa>cAa	p.R662Q	SP110_ENST00000358662.4_Missense_Mutation_p.R638Q	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	638	Bromo.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		GCGCATGTCTCGCACAAACCA	0.443000													43	62					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187953	140187953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140187953C>T	ENST00000530339.1	+	1	1181	c.1181C>T	c.(1180-1182)cCc>cTc	p.P394L	PCDHA4_ENST00000512229.2_Missense_Mutation_p.P394L|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.P394L|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCACGTCCCCTTCAAGCTG	0.592000													19	173					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155156834	155156834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:155156834G>A	ENST00000357232.3	-	25	7604	c.7605C>T	c.(7603-7605)ttC>ttT	p.F2535F		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2535					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.F2535F(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGCTGCTGGCGAACACTGCCA	0.388000													29	69					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5072529	5072529	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:5072529T>C	ENST00000381652.3	+	13	2173	c.1679T>C	c.(1678-1680)tTt>tCt	p.F560S	JAK2_ENST00000539801.1_Missense_Mutation_p.F560S|JAK2_ENST00000544510.1_Missense_Mutation_p.F411S	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	560	Protein kinase 1.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		ACAAAGATTTTTAAAGGCGTA	0.373000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				25	53					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47515777	47515777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47515777C>T	ENST00000371901.3	+	12	1711	c.1461C>T	c.(1459-1461)ttC>ttT	p.F487F	CYP4X1_ENST00000538609.1_Silent_p.F486F	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	487						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						CTCTTACTTTCCCCAACCATT	0.448000													43	127					0	0	1	0	0
PITX3	5309	broad.mit.edu	37	10	103990562	103990562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:103990562C>T	ENST00000370002.3	-	4	771	c.618G>A	c.(616-618)ccG>ccA	p.P206P	PITX3_ENST00000539804.1_Silent_p.P206P	NM_005029.3	NP_005020.1	O75364	PITX3_HUMAN	paired-like homeodomain 3	206					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(2)	5		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCACGGTGCCCGGGGCAGCCG	0.761000													4	3					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81172151	81172151	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:81172151C>T	ENST00000394685.3	+	5	755	c.336C>T	c.(334-336)gcC>gcT	p.A112A	KIAA1199_ENST00000356249.5_Silent_p.A112A|KIAA1199_ENST00000220244.3_Silent_p.A112A			Q8WUJ3	K1199_HUMAN	KIAA1199	112	G8.									breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CTGGGAGTGCCCTCTGCCCTT	0.517000													10	92					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461033	48461033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:48461033G>A	ENST00000358536.4	-	11	2931	c.2662C>T	c.(2662-2664)Ccg>Tcg	p.P888S	PLXNB1_ENST00000296440.6_Missense_Mutation_p.P888S|PLXNB1_ENST00000358459.4_Missense_Mutation_p.P705S|PLXNB1_ENST00000456774.1_Missense_Mutation_p.P705S|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	888					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGGCTGGACGGGAGGATGAGG	0.672000													11	31					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49685891	49685891	+	Silent	SNP	C	C	T	rs145772095		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:49685891C>T	ENST00000252826.5	+	11	1446	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F	TRPM4_ENST00000427978.2_Silent_p.F440F|TRPM4_ENST00000601347.1_3'UTR|TRPM4_ENST00000355712.5_Silent_p.F86F	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	440					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGCCTGAGTTCGTGCGCTTGC	0.607000													7	71					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24256521	24256521	+	Silent	SNP	G	G	A	rs141164035		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:24256521G>A	ENST00000538205.1	+	10	1207	c.660G>A	c.(658-660)ggG>ggA	p.G220G	ADAMDEC1_ENST00000522298.1_Silent_p.G220G|ADAMDEC1_ENST00000256412.4_Silent_p.G299G|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	299	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding	p.G299G(1)		NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CTAACCTGGGGAAAAAGATCC	0.512000													17	36					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29293604	29293604	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:29293604G>A	ENST00000331664.5	-	1	3523	c.3524C>T	c.(3523-3525)tCg>tTg	p.S1175L		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1175					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TCTCCGCTGCGAGTCTGCTCT	0.657000													17	58					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021916	5021916	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:5021916G>A	ENST00000382545.3	+	2	2479	c.1372G>A	c.(1372-1374)Gaa>Aaa	p.E458K	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	458					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATGGAGATCGAAGAGGATAT	0.463000													68	139					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49848490	49848490	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:49848490C>T	ENST00000333486.3	-	10	1315	c.1157G>A	c.(1156-1158)tGg>tAg	p.W386*		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	386	2 approximate repeats.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AAAGTAAAGCCACTGGTCCAG	0.602000													15	41					0	0	1	0	0
SFSWAP	6433	broad.mit.edu	37	12	132212883	132212883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:132212883C>T	ENST00000261674.4	+	7	1132	c.991C>T	c.(991-993)Cgt>Tgt	p.R331C	SFSWAP_ENST00000541286.1_Missense_Mutation_p.R331C	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	331					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding	p.R331C(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						AGCACTTGTTCGTAAGGCACA	0.552000													42	81					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47605951	47605951	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47605951C>T	ENST00000263774.4	+	7	795	c.713C>T	c.(712-714)cCc>cTc	p.P238L	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	238					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	CTGAACAGCCCCTGGGAGGCT	0.557000													47	113					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41019027	41019027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41019027C>T	ENST00000399564.4	-	25	2985	c.2535G>A	c.(2533-2535)ctG>ctA	p.L845L	MROH2B_ENST00000506092.2_Silent_p.L400L	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CTTCACTTTTCAGATTTTCCA	0.473000													13	30					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27692272	27692272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:27692272C>T	ENST00000438700.3	-	3	1343	c.1226G>A	c.(1225-1227)cGa>cAa	p.R409Q		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	409	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CATTTTGTTTCGTATGCAGTC	0.443000													35	54					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176820706	176820706	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:176820706C>T	ENST00000324417.5	+	9	1039	c.948C>T	c.(946-948)tcC>tcT	p.S316S	SLC34A1_ENST00000513614.1_3'UTR	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	316					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCCCACCTCCATGTCCAGAG	0.552000													22	86					0	0	1	0	0
POPDC3	64208	broad.mit.edu	37	6	105609583	105609583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:105609583C>T	ENST00000254765.3	-	2	480	c.202G>A	c.(202-204)Gct>Act	p.A68T	BVES-AS1_ENST00000580854.1_RNA|BVES-AS1_ENST00000580511.1_RNA|POPDC3_ENST00000474760.1_Intron|BVES-AS1_ENST00000369122.3_RNA	NM_022361.4	NP_071756.2	Q9HBV1	POPD3_HUMAN	popeye domain containing 3	68						integral to membrane				NS(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(3)|urinary_tract(1)	26		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				TCTACCCAAGCCCAGACAGCA	0.423000													45	55					0	0	1	0	0
ENO1	2023	broad.mit.edu	37	1	8924025	8924025	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8924025G>T	ENST00000234590.4	-	9	1111	c.992C>A	c.(991-993)gCc>gAc	p.A331D		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	331					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CTCGTTCACGGCCTTGGCGAT	0.567000													81	212					2.61628e-32	2.63424e-32	1	1	0
IGHV3-21	28444	broad.mit.edu	37	14	106692098	106692098	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106692098G>A	ENST00000390607.2	-	0	105																											TAGCAACAAGGAAAACCCAGC	0.483000													60	167					0	0	1	0	0
CLCN3	1182	broad.mit.edu	37	4	170618355	170618355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:170618355C>T	ENST00000513761.1	+	9	1592	c.1033C>T	c.(1033-1035)Cct>Tct	p.P345S	CLCN3_ENST00000504131.2_Missense_Mutation_p.P328S|CLCN3_ENST00000360642.3_Missense_Mutation_p.P318S|CLCN3_ENST00000347613.4_Missense_Mutation_p.P345S	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	345					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		CTATTATTTTCCTCTCAAAAC	0.294000													35	64					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54902260	54902260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54902260C>T	ENST00000293373.6	+	5	530	c.451C>T	c.(451-453)Cgg>Tgg	p.R151W	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R101W	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	151					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GATTGAAGATCGGCGGATACT	0.423000													99	155					0	0	1	0	0
PIH1D3	139212	broad.mit.edu	37	X	106482183	106482183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:106482183C>T	ENST00000535523.1	+	7	798	c.461C>T	c.(460-462)tCt>tTt	p.S154F	PIH1D3_ENST00000372453.3_Missense_Mutation_p.S154F|PIH1D3_ENST00000336387.4_Missense_Mutation_p.S154F	NM_001169154.1	NP_001162625.1			PIH1 domain containing 3																		ACAAACCCTTCTGATATTCAA	0.299000													27	12					0	0	1	0	0
FAM78B	149297	broad.mit.edu	37	1	166135291	166135291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:166135291G>A	ENST00000338353.3	-	2	784	c.195C>T	c.(193-195)acC>acT	p.T65T	FAM78B_ENST00000354422.3_Silent_p.T65T			Q5VT40	FA78B_HUMAN	family with sequence similarity 78, member B	65										central_nervous_system(1)|endometrium(5)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					CCACCACCCAGGTCTCGTGGC	0.652000													13	24					0	0	1	0	0
CD3E	916	broad.mit.edu	37	11	118183534	118183534	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:118183534G>A	ENST00000361763.4	+	6	596	c.305G>A	c.(304-306)gGa>gAa	p.G102E	CD3E_ENST00000528600.1_Missense_Mutation_p.G96E	NM_000733.3	NP_000724.1	P07766	CD3E_HUMAN	CD3e molecule, epsilon (CD3-TCR complex)	102	Ig-like.				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|ovary(2)|stomach(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	TACCCCAGAGGAAGCAAACCA	0.458000													14	109					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43763125	43763125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:43763125C>T	ENST00000389420.3	-	37	5505	c.5506G>A	c.(5506-5508)Gga>Aga	p.G1836R		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1836	GON.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TAGCAATCTCCAGCTGTGGCA	0.318000													4	14					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61424021	61424021	+	Missense_Mutation	SNP	C	C	T	rs145829924		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61424021C>T	ENST00000395348.3	-	4	1036	c.400G>A	c.(400-402)Gat>Aat	p.D134N	SLC16A9_ENST00000395347.1_Missense_Mutation_p.D134N	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	134					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						CCTCGGCGATCGTCAAAATAC	0.393000													27	53					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38949552	38949552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38949552G>A	ENST00000302328.3	-	10	1559	c.1361C>T	c.(1360-1362)aCc>aTc	p.T454I	SCN11A_ENST00000456224.3_Missense_Mutation_p.T454I|SCN11A_ENST00000444237.2_Missense_Mutation_p.T454I|SCN11A_ENST00000450244.1_Missense_Mutation_p.T454I	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	454					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTTTTTGGGGTAAAATATGA	0.388000													36	94					0	0	1	0	0
DEFB114	245928	broad.mit.edu	37	6	49928133	49928133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:49928133G>A	ENST00000322066.3	-	2	81	c.82C>T	c.(82-84)Cgt>Tgt	p.R28C		NM_001037499.1	NP_001032588.1	Q30KQ6	DB114_HUMAN	defensin, beta 114	28					defense response to bacterium	extracellular region		p.R28C(1)		kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	Lung NSC(77;0.042)					TTGGTGCAACGATCAGCATTC	0.353000													13	51					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107706335	107706335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:107706335G>A	ENST00000388781.3	-	21	2791	c.2708C>T	c.(2707-2709)tCt>tTt	p.S903F	LAMB4_ENST00000205386.4_Missense_Mutation_p.S903F|LAMB4_ENST00000388780.3_Missense_Mutation_p.S903F	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	903	Laminin EGF-like 8.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CTGTCCTGAAGAAGGATTTCC	0.433000													8	118					0	0	1	0	0
ZNF605	100289635	broad.mit.edu	37	12	133502373	133502373	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:133502373G>A	ENST00000360187.4	-	5	1860	c.1512C>T	c.(1510-1512)ccC>ccT	p.P504P	ZNF605_ENST00000392321.3_Silent_p.P535P	NM_183238.3	NP_899061.1	Q86T29	ZN605_HUMAN	zinc finger protein 605	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(16)|large_intestine(5)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00227)|all_epithelial(31;0.142)		OV - Ovarian serous cystadenocarcinoma(86;9.24e-09)|Epithelial(86;2.11e-07)|all cancers(50;5.27e-06)		TACATTCAAAGGGCTTTTCTC	0.428000													20	25					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70987106	70987106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70987106G>A	ENST00000354624.5	+	2	340	c.207G>A	c.(205-207)agG>agA	p.R69R	HKDC1_ENST00000395086.2_Silent_p.R69R|RP11-227H15.4_ENST00000450995.1_RNA	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	69					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CCTTCGTCAGGGCCATTCCCG	0.582000													12	45					0	0	1	0	0
TPM2	7169	broad.mit.edu	37	9	35685445	35685445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:35685445G>A	ENST00000378292.3	-	4	1680	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	TPM2_ENST00000329305.2_Missense_Mutation_p.R160C|TPM2_ENST00000360958.2_Missense_Mutation_p.R160C|TPM2_ENST00000378300.5_Missense_Mutation_p.R160C	NM_213674.1	NP_998839.1	P07951	TPM2_HUMAN	tropomyosin 2 (beta)	160					muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle	p.R160S(2)		NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCATATTTGCGGTCTGAATCC	0.542000													28	120					0	0	1	0	0
POLR3D	661	broad.mit.edu	37	8	22106037	22106037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:22106037C>T	ENST00000397802.4	+	5	745	c.530C>T	c.(529-531)cCt>cTt	p.P177L	POLR3D_ENST00000306433.4_Missense_Mutation_p.P177L			P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	177					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	13				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CGAAATATGCCTGTGCAGCTG	0.537000													40	88					0	0	1	0	0
UBE2U	148581	broad.mit.edu	37	1	64671357	64671357	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:64671357G>A	ENST00000371077.4	+	2	526	c.102G>A	c.(100-102)atG>atA	p.M34I	UBE2U_ENST00000371076.3_Missense_Mutation_p.M34I			Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)	34							ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(3)|lung(2)|skin(1)	6						AAGATATGATGGAATGGGAAG	0.274000													21	92					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16170511	16170511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:16170511C>T	ENST00000380289.2	+	3	1296	c.898C>T	c.(898-900)Cac>Tac	p.H300Y		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	300					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					CTCCATGCTCCACTTTGTCAC	0.562000													77	88					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2717815	2717815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:2717815C>T	ENST00000399655.1	+	27	3760	c.3495C>T	c.(3493-3495)gtC>gtT	p.V1165V	CACNA1C_ENST00000347598.4_Silent_p.V1185V|CACNA1C_ENST00000399591.1_Silent_p.V1165V|CACNA1C_ENST00000480911.1_Silent_p.V1165V|CACNA1C_ENST00000344100.3_Silent_p.V1165V|CACNA1C_ENST00000399597.1_Silent_p.V1165V|CACNA1C_ENST00000335762.5_Silent_p.V1190V|CACNA1C_ENST00000399595.1_Silent_p.V1165V|CACNA1C_ENST00000399603.1_Silent_p.V1165V|CACNA1C_ENST00000399617.1_Silent_p.V1165V|CACNA1C_ENST00000399606.1_Silent_p.V1185V|CACNA1C_ENST00000399621.1_Silent_p.V1165V|CACNA1C_ENST00000399601.1_Silent_p.V1165V|CACNA1C_ENST00000399638.1_Silent_p.V1165V|CACNA1C_ENST00000399649.1_Silent_p.V1165V|CACNA1C_ENST00000399644.1_Silent_p.V1165V|CACNA1C_ENST00000399629.1_Silent_p.V1165V|CACNA1C_ENST00000327702.7_Silent_p.V1165V|CACNA1C_ENST00000399634.1_Silent_p.V1165V|CACNA1C_ENST00000399637.1_Silent_p.V1165V|CACNA1C_ENST00000406454.3_Silent_p.V1165V|CACNA1C_ENST00000402845.3_Silent_p.V1165V|CACNA1C_ENST00000399641.1_Silent_p.V1165V	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1185	Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	tgggcttcgtcatcgtcaccT	0.532000													12	37					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38917285	38917285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38917285G>A	ENST00000359357.3	+	79	11790	c.11536G>A	c.(11536-11538)Gaa>Aaa	p.E3846K	DNAH8_ENST00000441566.1_Missense_Mutation_p.E3810K|DNAH8_ENST00000449981.2_Missense_Mutation_p.E4063K|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TCCAGAGGAGGAAATTATCCC	0.388000													32	130					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73206137	73206137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:73206137G>A	ENST00000224721.6	+	2	135	c.130G>A	c.(130-132)Gag>Aag	p.E44K	CDH23_ENST00000299366.7_Missense_Mutation_p.E89K|CDH23_ENST00000398809.4_Missense_Mutation_p.E44K|CDH23_ENST00000461841.3_Missense_Mutation_p.E89K|CDH23_ENST00000398842.3_Missense_Mutation_p.E44K	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	44	Cadherin 1.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCTGATCAGCGAGGACACGCC	0.587000													23	46					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21235111	21235111	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21235111G>A	ENST00000233242.1	-	26	4756	c.4629C>T	c.(4627-4629)tcC>tcT	p.S1543S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1543					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGAGGTGAGGGAGAGGGTTC	0.468000													24	78					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71538258	71538258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71538258G>A	ENST00000265382.3	+	12	1462	c.1157G>A	c.(1156-1158)aGa>aAa	p.R386K	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.R386K	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	386	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		TATGCAGACAGATTTCTTAAG	0.328000													17	71					0	0	1	0	0
RASSF8	11228	broad.mit.edu	37	12	26217491	26217491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:26217491C>T	ENST00000405154.2	+	3	363	c.164C>T	c.(163-165)cCt>cTt	p.P55L	RASSF8_ENST00000541490.1_Missense_Mutation_p.P55L|RASSF8_ENST00000381352.3_Missense_Mutation_p.P55L|RASSF8_ENST00000542865.1_Missense_Mutation_p.P55L|RASSF8_ENST00000282884.9_Missense_Mutation_p.P55L	NM_001164748.1	NP_001158220.1	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	55	Ras-associating.				signal transduction					cervix(2)|endometrium(1)|large_intestine(6)|lung(15)|urinary_tract(1)	25	Colorectal(261;0.0847)					CACTTAGCACCTCATGAAAAT	0.428000													27	119					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921586	247921586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:247921586C>T	ENST00000408896.2	-	1	396	c.123G>A	c.(121-123)ggG>ggA	p.G41G		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGAGCATGTTCCCCAAGGTGG	0.483000													10	31					0	0	1	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156725803	156725803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:156725803C>T	ENST00000264424.8	+	12	1695	c.1613C>T	c.(1612-1614)cCt>cTt	p.P538L	GUCY1B3_ENST00000505154.1_Missense_Mutation_p.P470L|GUCY1B3_ENST00000507146.1_Missense_Mutation_p.P513L|GUCY1B3_ENST00000503520.1_Missense_Mutation_p.P505L|GUCY1B3_ENST00000505764.1_Missense_Mutation_p.P518L|GUCY1B3_ENST00000513437.1_Missense_Mutation_p.P470L|GUCY1B3_ENST00000502959.1_Missense_Mutation_p.P560L	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	538	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		CAGCGGATGCCTCGATACTGT	0.398000													13	100					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44975176	44975176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:44975176C>T	ENST00000340446.4	-	1	1306	c.1015G>A	c.(1015-1017)Gaa>Aaa	p.E339K		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	339	Pro-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		GGAGACTCTTCAGCTGATGGA	0.517000													33	117					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183245205	183245205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183245205C>T	ENST00000511685.1	+	2	155	c.32C>T	c.(31-33)tCc>tTc	p.S11F	TENM3_ENST00000406950.2_Missense_Mutation_p.S11F					teneurin transmembrane protein 3																		CCTTACTGCTCCCTGACCAAG	0.522000													13	28					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57809130	57809130	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:57809130C>T	ENST00000281282.5	+	9	2634	c.2556C>T	c.(2554-2556)atC>atT	p.I852I		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	852						myosin complex|tight junction	motor activity	p.I852I(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AAAGGCAGATCGAGGACCTGA	0.577000													8	32					0	0	1	0	0
KANSL1L	151050	broad.mit.edu	37	2	211018911	211018911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:211018911G>A	ENST00000281772.9	-	2	659	c.396C>T	c.(394-396)ttC>ttT	p.F132F	KANSL1L_ENST00000452086.1_Silent_p.F132F|KANSL1L_ENST00000429908.2_5'UTR|KANSL1L_ENST00000457374.1_Silent_p.F132F|KANSL1L_ENST00000418791.1_Silent_p.F132F	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	132																	CCTTTTTGATGAACTCTTCAG	0.368000													35	85					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46868965	46868965	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:46868965C>T	ENST00000393382.3	-	9	1140	c.998_splice	c.e9-1	p.R333_splice	TTLL6_ENST00000433608.2_Splice_Site_p.R26_splice	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	285	TTL.					cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						TGGAGAGCTTCCTGGAAGGGA	0.562000											OREG0024526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	19					0	0	1	0	0
GOLGA7	51125	broad.mit.edu	37	8	41355058	41355058	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:41355058C>T	ENST00000357743.4	+	2	343	c.142C>T	c.(142-144)Cga>Tga	p.R48*	GOLGA7_ENST00000520817.1_Nonsense_Mutation_p.R48*|GOLGA7_ENST00000518270.1_Nonsense_Mutation_p.R48*|GOLGA7_ENST00000405786.2_Nonsense_Mutation_p.R48*	NM_001002296.1	NP_001002296.1	Q7Z5G4	GOGA7_HUMAN	golgin A7	48						Golgi membrane				breast(1)|large_intestine(1)	2	Ovarian(28;0.014)|Colorectal(14;0.0234)|Lung SC(25;0.211)	all_lung(54;0.000771)|Lung NSC(58;0.0031)|Hepatocellular(245;0.014)|Esophageal squamous(32;0.0559)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00596)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AGAAACAGTTCGAACTCTAAA	0.348000													76	137					0	0	1	0	0
MPPE1	65258	broad.mit.edu	37	18	11886545	11886545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:11886545G>A	ENST00000588072.1	-	9	2041	c.820C>T	c.(820-822)Cca>Tca	p.P274S	MPPE1_ENST00000309976.9_Intron|MPPE1_ENST00000399978.2_Missense_Mutation_p.P275S|MPPE1_ENST00000317235.7_Intron|MPPE1_ENST00000344987.7_Missense_Mutation_p.P252S	NM_023075.5	NP_075563.3	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1	274					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	5						TCCTTAAATGGGATGTCCCTT	0.507000													26	51					0	0	1	0	0
CTD-2090I13.1	0	broad.mit.edu	37	1	227618464	227618464	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:227618464C>T	ENST00000445817.1	+	0	1699																											AGTACAAGATCCCGGACTGGT	0.488000													7	18					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202052442	202052442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:202052442G>A	ENST00000286186.6	+	3	796	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K	CASP10_ENST00000492363.1_3'UTR|CASP10_ENST00000374650.3_Missense_Mutation_p.E121K|CASP10_ENST00000360132.3_Missense_Mutation_p.E121K|CASP10_ENST00000313728.7_Missense_Mutation_p.E121K|CASP10_ENST00000272879.5_Missense_Mutation_p.E121K|CASP10_ENST00000448480.1_Missense_Mutation_p.E121K|CASP10_ENST00000346817.5_Missense_Mutation_p.E121K	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	121	DED 2.				apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						CCTGCTCTACGAACTGTCAGA	0.403000													34	95					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269704	150269704	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:150269704C>T	ENST00000255945.2	+	3	721	c.546C>T	c.(544-546)ttC>ttT	p.F182F	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Silent_p.F196F	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	182							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGACATTTTCGGTGACCGCT	0.512000													44	92					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120845	94120845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:94120845C>T	ENST00000369303.4	-	3	390	c.206G>A	c.(205-207)cGa>cAa	p.R69Q	EPHA7_ENST00000369297.1_Missense_Mutation_p.R69Q	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	69						integral to plasma membrane	ATP binding|ephrin receptor activity	p.R69Q(1)		NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTGGTATGTTCGTATCGGGGT	0.393000													35	61					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62844957	62844957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:62844957G>A	ENST00000536311.1	+	10	1952	c.1588G>A	c.(1588-1590)Gga>Aga	p.G530R	MYT1_ENST00000328439.1_Missense_Mutation_p.G530R|MYT1_ENST00000360149.4_Missense_Mutation_p.G232R			Q01538	MYT1_HUMAN	myelin transcription factor 1	530					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCCGCAGACAGGAGATCCTTC	0.542000													27	45					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81647354	81647354	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:81647354C>T	ENST00000548058.1	+	15	2810	c.1900C>T	c.(1900-1902)Cga>Tga	p.R634*	ACSS3_ENST00000548324.1_Nonsense_Mutation_p.R316*|ACSS3_ENST00000261206.3_Nonsense_Mutation_p.R633*			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	634						mitochondrion	acetate-CoA ligase activity|ATP binding	p.R634*(2)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GGCTGCTTTTCGAAATGCAGT	0.428000													21	93					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251424	25251424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:25251424G>A	ENST00000328086.7	-	7	3420	c.2617C>T	c.(2617-2619)Cat>Tat	p.H873Y		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	873					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		GCGCTGAAATGAGAACTGTTG	0.453000													25	49					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101491710	101491710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:101491710G>A	ENST00000392979.3	+	20	2249	c.1888G>A	c.(1888-1890)Gaa>Aaa	p.E630K	ANO4_ENST00000392977.3_Missense_Mutation_p.E665K|ANO4_ENST00000550015.1_Missense_Mutation_p.E185K|ANO4_ENST00000299222.9_Missense_Mutation_p.E185K	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	665						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						taatttcatggaacttggcta	0.413000										HNSCC(74;0.22)			46	104					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142435638	142435638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:142435638C>T	ENST00000378004.3	+	16	1774	c.1419C>T	c.(1417-1419)ttC>ttT	p.F473F	ARHGAP26_ENST00000274498.4_Silent_p.F473F	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	473	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAGAAGTTTCATCAAAGCAG	0.343000													12	135					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201286864	201286864	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:201286864C>T	ENST00000263946.3	+	5	1262	c.1011C>T	c.(1009-1011)ctC>ctT	p.L337L	PKP1_ENST00000475988.1_3'UTR|PKP1_ENST00000352845.3_Silent_p.L337L|PKP1_ENST00000367324.3_Silent_p.L337L	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	337					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						CAGTCAGCCTCCTGAGGAGAA	0.647000													11	31					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75111616	75111616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:75111616G>A	ENST00000379709.3	+	6	723	c.721G>A	c.(721-723)Gag>Aag	p.E241K	LMAN1L_ENST00000309664.5_Intron			Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	241	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCTGGCAGGTGAGGATCCCAC	0.572000													44	167					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124348598	124348598	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:124348598G>A	ENST00000338354.3	+	17	2028	c.1922G>A	c.(1921-1923)aGg>aAg	p.R641K	DMBT1_ENST00000344338.3_Missense_Mutation_p.R631K|DMBT1_ENST00000368955.3_Missense_Mutation_p.R631K|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368909.3_Missense_Mutation_p.R641K			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	641	SRCR 5.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTGGTCTGCAGGCAGCTGGGC	0.612000													36	389					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23763453	23763453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:23763453G>A	ENST00000336689.3	-	15	1471	c.1427C>T	c.(1426-1428)tCg>tTg	p.S476L	ASAP3_ENST00000437606.2_Missense_Mutation_p.S467L|ASAP3_ENST00000484906.1_5'UTR	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	476	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						CTGCATGCGCGAAAAGCGCAC	0.662000													3	27					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519613	113519613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:113519613C>T	ENST00000284601.3	-	4	1602	c.1534G>A	c.(1534-1536)Ggc>Agc	p.G512S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	512					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTACCATTGCCATAATAATCT	0.323000													10	34					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610048	47610048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47610048G>A	ENST00000371890.3	+	6	691	c.655G>A	c.(655-657)Gaa>Aaa	p.E219K	CYP4A22_ENST00000294337.3_Silent_p.R270R|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000371891.3_Silent_p.R270R|CYP4A22_ENST00000485117.1_3'UTR			Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	0						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCCAACTGAGGAAGGCTCAAC	0.542000													23	118					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390723	197390723	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:197390723G>A	ENST00000367400.3	+	6	1900	c.1765G>A	c.(1765-1767)Gag>Aag	p.E589K	CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000544212.1_Missense_Mutation_p.E70K|CRB1_ENST00000538660.1_Missense_Mutation_p.E589K|CRB1_ENST00000367399.2_Missense_Mutation_p.E477K|CRB1_ENST00000543483.1_Intron|CRB1_ENST00000535699.1_Missense_Mutation_p.E520K	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	589	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTCCTGTAAGGAGAAATGCAT	0.458000													36	117					0	0	1	0	0
BTBD17	388419	broad.mit.edu	37	17	72356361	72356361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:72356361C>T	ENST00000375366.3	-	2	235	c.109G>A	c.(109-111)Gag>Aag	p.E37K		NM_001080466.1	NP_001073935.1	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17	37						extracellular region				endometrium(1)|kidney(1)|lung(4)	6						CCAGCTGCCTCCCCGCCAACA	0.652000													3	15					0	0	1	0	0
ARRDC2	27106	broad.mit.edu	37	19	18121442	18121442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:18121442C>T	ENST00000222250.4	+	7	1217	c.1074C>T	c.(1072-1074)ccC>ccT	p.P358P	ARRDC2_ENST00000379656.2_Silent_p.P353P	NM_015683.1	NP_056498.1	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2	358										endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)	12						GGCAGAGCCCCTTCCCGCTTC	0.632000													37	78					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60689058	60689058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:60689058G>A	ENST00000335712.6	-	4	1216	c.989C>T	c.(988-990)cCg>cTg	p.P330L	BCL11A_ENST00000538214.1_Missense_Mutation_p.P296L|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000356842.4_Missense_Mutation_p.P330L|BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000358510.4_Missense_Mutation_p.P296L	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	330	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGGGGACAGCGGTGGGCTAGA	0.612000			T	IGH@	B-CLL								57	138					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202266700	202266700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:202266700G>A	ENST00000367278.3	+	7	870	c.781G>A	c.(781-783)Gaa>Aaa	p.E261K	LGR6_ENST00000439764.2_Missense_Mutation_p.E122K|LGR6_ENST00000308543.3_3'UTR|LGR6_ENST00000255432.7_Missense_Mutation_p.E209K	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	261						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						CAGACTGCAGGAACTGTAAGC	0.557000													30	81					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31150654	31150654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31150654C>T	ENST00000268281.4	-	15	2431	c.2373G>A	c.(2371-2373)gaG>gaA	p.E791E	PRSS36_ENST00000569305.1_Silent_p.E786E|PRSS36_ENST00000418068.2_Silent_p.E688E	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	791	Peptidase S1 3.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						CAGCAAACAGCTCCCGGCTCC	0.632000													8	56					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984599	85984599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:85984599G>A	ENST00000372113.4	-	2	387	c.382C>T	c.(382-384)Ctc>Ttc	p.L128F	LRIT2_ENST00000538192.1_Missense_Mutation_p.L128F	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	128						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						ACCCTCAGGAGAGGGGTGGCA	0.557000													43	124					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657918	143657918	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:143657918G>A	ENST00000392899.1	+	1	892	c.855G>A	c.(853-855)ctG>ctA	p.L285L		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					CACCAATGCTGAACCCCATGA	0.453000													21	103					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148463635	148463635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:148463635C>T	ENST00000324300.5	+	8	1664	c.1149C>T	c.(1147-1149)tgC>tgT	p.C383C	EDNRA_ENST00000511804.1_Silent_p.C158C|EDNRA_ENST00000358556.4_Silent_p.C274C|EDNRA_ENST00000339690.5_3'UTR|EDNRA_ENST00000503721.1_3'UTR|EDNRA_ENST00000506066.1_Silent_p.C274C	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	383					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CCCAGTCATGCCTCTGCTGCT	0.547000													23	76					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49428229	49428229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49428229G>A	ENST00000301067.7	-	37	10470	c.10471C>T	c.(10471-10473)Cgt>Tgt	p.R3491C		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGGTTGGGACGAGGCTGGGAG	0.587000													9	12					0	0	1	0	0
GTF3C6	112495	broad.mit.edu	37	6	111283616	111283616	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:111283616A>T	ENST00000329970.7	+	5	479	c.269A>T	c.(268-270)aAa>aTa	p.K90I	GTF3C6_ENST00000480191.1_3'UTR	NM_138408.3	NP_612417.1	Q969F1	TF3C6_HUMAN	general transcription factor IIIC, polypeptide 6, alpha 35kDa	90						transcription factor TFIIIC complex	DNA binding|protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_cancers(87;0.00328)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|Colorectal(196;0.0466)|all_epithelial(87;0.0575)		OV - Ovarian serous cystadenocarcinoma(136;0.105)|all cancers(137;0.179)|Epithelial(106;0.186)		GGCAATAATAAAACAGTGCTA	0.348000													12	16					0	0	1	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709191	128709191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:128709191C>T	ENST00000392665.2	-	2	1092	c.948G>A	c.(946-948)ggG>ggA	p.G316G	KCNJ1_ENST00000324036.3_Silent_p.G316G|KCNJ1_ENST00000392666.1_Silent_p.G316G|KCNJ1_ENST00000392664.2_Silent_p.G335G|KCNJ1_ENST00000440599.2_Silent_p.G316G	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	335					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity	p.G335G(1)		breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CTCGGTATTTCCCTTCCTTTG	0.493000													26	60					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648104	130648104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:130648104C>T	ENST00000229030.4	+	1	1101	c.617C>T	c.(616-618)tCg>tTg	p.S206L	FZD10_ENST00000539839.1_Silent_p.V173V			Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	206					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		AAGAGCGCGTCGTGCGCGCCG	0.726000													4	22					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58491150	58491150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:58491150G>A	ENST00000341164.4	-	7	1518	c.898C>T	c.(898-900)Cat>Tat	p.H300Y	ZNF606_ENST00000536132.1_Missense_Mutation_p.H210Y	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TGTATTATATGATTGAAAGAT	0.318000													22	64					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48538680	48538680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:48538680C>T	ENST00000427954.2	+	4	520	c.477C>T	c.(475-477)tcC>tcT	p.S159S	ACSF2_ENST00000300441.4_Silent_p.S134S|ACSF2_ENST00000541920.1_Intron|ACSF2_ENST00000502667.1_Silent_p.S134S|ACSF2_ENST00000504392.1_Intron			Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	134					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GACCTAACTCCTATGCATGGG	0.587000													12	23					0	0	1	0	0
IGHV1-8	28472	broad.mit.edu	37	14	106539304	106539304	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:106539304C>T	ENST00000390599.2	-	0	187																											ATCCAGAAGCCTTGCAGGAGA	0.562000													75	40					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183913377	183913377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:183913377C>T	ENST00000361927.4	-	10	1721	c.1350G>A	c.(1348-1350)atG>atA	p.M450I	COLGALT2_ENST00000367521.1_Missense_Mutation_p.M58I|COLGALT2_ENST00000367520.3_Missense_Mutation_p.M187I|COLGALT2_ENST00000546159.1_Missense_Mutation_p.M450I	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		CCATCAGCTTCATCAGCTTCT	0.453000													27	85					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124989729	124989729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:124989729C>T	ENST00000522917.1	+	10	1149	c.943C>T	c.(943-945)Cct>Tct	p.P315S	FER1L6_ENST00000399018.1_Missense_Mutation_p.P315S	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	315	C2 2.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGAAATGTTCCCTCCCTTGTG	0.498000													33	83					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106846214	106846214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:106846214G>A	ENST00000276185.4	+	16	5044	c.5044G>A	c.(5044-5046)Gac>Aac	p.D1682N				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1682						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GGCCAATGTGGACAAGAGCCC	0.587000													21	19					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42162048	42162048	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:42162048C>T	ENST00000444063.1	+	10	1365	c.1233C>T	c.(1231-1233)acC>acT	p.T411T	L3MBTL1_ENST00000427442.2_Silent_p.T479T|L3MBTL1_ENST00000373134.1_Silent_p.T411T|L3MBTL1_ENST00000373135.3_Silent_p.T411T|L3MBTL1_ENST00000418998.1_Silent_p.T479T			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	411					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						AGCCCCTCACCCCTCCACAAG	0.592000													14	62					0	0	1	0	0
AKR1C3	8644	broad.mit.edu	37	10	5141002	5141002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:5141002G>A	ENST00000380554.3	+	4	1030	c.378G>A	c.(376-378)gaG>gaA	p.E126E	AKR1C3_ENST00000605149.1_Silent_p.E103E|AKR1C3_ENST00000439082.2_Silent_p.E7E	NM_001253908.1|NM_003739.5	NP_001240837.1|NP_003730.4	P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3	126					prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	AGCCAGGTGAGGAACTTTCAC	0.428000													15	44					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79060533	79060533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79060533G>A	ENST00000388820.4	-	17	2797	c.2587C>T	c.(2587-2589)Ccc>Tcc	p.P863S	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	863	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CGGCCCAGGGGGTCACAGTGC	0.697000													10	11					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33877622	33877622	+	Silent	SNP	C	C	G	rs143026467		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:33877622C>G	ENST00000307296.3	+	8	1298	c.921C>G	c.(919-921)gcC>gcG	p.A307A	PDCD6IP_ENST00000457054.2_Silent_p.A312A			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	307	BRO1.|Interaction with CHMP4A, CHMP4B and CHMP4C.|Interaction with EIAV p9.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						TCAATCGTGCCCTTGCTGCAG	0.373000													63	145					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43279991	43279991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:43279991C>T	ENST00000374518.4	+	2	212	c.149C>T	c.(148-150)gCt>gTt	p.A50V		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	50					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GTTCAGTCTGCTGTGCGGATG	0.468000													33	123					0	0	1	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37964342	37964342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:37964342C>T	ENST00000249014.4	+	3	1111	c.691C>T	c.(691-693)Ccc>Tcc	p.P231S		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	231	8 X 7 AA tandem repeats of [PT]-[AT]-A- [ENT]-[PT]-[PTS]-[AG].				positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					CGCTGCAAACCCCCCAGCCCC	0.672000													12	33					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41550893	41550893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41550893C>T	ENST00000400454.1	-	15	3385	c.2908G>A	c.(2908-2910)Gag>Aag	p.E970K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	970	Fibronectin type-III 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTGCTGGGCTCGCTCTTGCCA	0.602000													16	47					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36714350	36714350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:36714350G>A	ENST00000216181.5	-	11	1359	c.1129C>T	c.(1129-1131)Ctc>Ttc	p.L377F		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	377	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						ATACCCAAGAGATGGGACACC	0.473000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				100	228					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153765949	153765949	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:153765949T>C	ENST00000297107.6	+	7	1152	c.1015T>C	c.(1015-1017)Ttg>Ctg	p.L339L	GALNT10_ENST00000377661.2_Silent_p.L277L|SAP30L-AS1_ENST00000519727.1_RNA|GALNT10_ENST00000519544.1_3'UTR|GALNT10_ENST00000425427.2_Silent_p.L339L	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	339	Catalytic subdomain B.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			TGACCCAGGCTTGGAGATCTG	0.592000													39	87					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125876306	125876306	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:125876306C>T	ENST00000393434.2	-	4	757	c.408G>A	c.(406-408)tgG>tgA	p.W136*	ALDH1L1_ENST00000393431.2_Nonsense_Mutation_p.W136*|ALDH1L1_ENST00000472186.1_Nonsense_Mutation_p.W136*|ALDH1L1_ENST00000452905.2_Intron|ALDH1L1_ENST00000273450.3_Nonsense_Mutation_p.W146*|ALDH1L1_ENST00000455064.2_5'UTR	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	136	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CATCATCCGCCCAGAAGATGG	0.572000													30	110					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88379792	88379792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:88379792G>A	ENST00000298699.2	-	11	1141	c.961C>T	c.(961-963)Cac>Tac	p.H321Y	C12orf50_ENST00000550553.1_Missense_Mutation_p.H282Y	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	321										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						TTATTGCGGTGATAACTCATT	0.453000													10	121					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119942902	119942902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:119942902G>A	ENST00000327554.2	+	7	1142	c.677G>A	c.(676-678)cGa>cAa	p.R226Q	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	226										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCCACAATGCGAGTCACCAAC	0.517000													30	116					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152883916	152883916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152883916C>T	ENST00000368764.3	+	2	1707	c.1643C>T	c.(1642-1644)gCt>gTt	p.A548V	IVL_ENST00000392667.2_Missense_Mutation_p.A402V			P07476	INVO_HUMAN	involucrin	548					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTTGCCCCAGCTCCAGGCCAG	0.592000													16	42					0	0	1	0	0
FNDC4	64838	broad.mit.edu	37	2	27716878	27716878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27716878C>T	ENST00000264703.3	-	4	764	c.373G>A	c.(373-375)Gga>Aga	p.G125R		NM_022823.2	NP_073734.1	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	125	Fibronectin type-III.					integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|prostate(1)|skin(1)	9	Acute lymphoblastic leukemia(172;0.155)					GGACTCTCTCCCCGAAGGCCG	0.607000													17	85					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123755273	123755273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:123755273C>T	ENST00000375026.2	-	2	468	c.252G>A	c.(250-252)ctG>ctA	p.L84L		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	84						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						ATTTCATACCCAGGATTAAGT	0.423000													34	67					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20634826	20634826	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20634826C>T	ENST00000219151.4	-	14	1879	c.669G>A	c.(667-669)aaG>aaA	p.K223K	ACSM1_ENST00000520010.1_Silent_p.K572K|ACSM1_ENST00000307493.4_Silent_p.K572K			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	572					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						GACCAGTCTCCTTTTTCCGAA	0.493000													17	67					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44477369	44477369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:44477369G>A	ENST00000360584.2	-	2	304	c.113C>T	c.(112-114)tCc>tTc	p.S38F	SLC6A9_ENST00000492434.2_Intron|SLC6A9_ENST00000372310.3_Intron|SLC6A9_ENST00000372306.3_Intron|SLC6A9_ENST00000537678.1_Intron|SLC6A9_ENST00000475075.2_Intron|SLC6A9_ENST00000372307.3_Intron|SLC6A9_ENST00000357730.2_Intron	NM_201649.3	NP_964012.2	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	38						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CAGGAAGAAGGATCTCTGAAC	0.597000													13	43					0	0	1	0	0
BVES	11149	broad.mit.edu	37	6	105549067	105549067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:105549067C>T	ENST00000314641.5	-	8	1196	c.980G>A	c.(979-981)cGa>cAa	p.R327Q	BVES_ENST00000336775.5_Missense_Mutation_p.R327Q|BVES_ENST00000446408.2_Missense_Mutation_p.R327Q	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	327					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity			NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				GGCAGAGGCTCGCTGGTGTGG	0.448000													16	28					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12618853	12618853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:12618853G>A	ENST00000425538.1	+	3	339	c.139G>A	c.(139-141)Gaa>Aaa	p.E47K	MYOCD_ENST00000343344.4_Missense_Mutation_p.E47K	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	47					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACGTCCAGCTGAATTCCATGA	0.418000													20	26					0	0	1	0	0
IL2	3558	broad.mit.edu	37	4	123374864	123374864	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:123374864C>T	ENST00000226730.4	-	3	636		c.e3+1			NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2						anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		TAATGCCTTACCTTTAGTTCC	0.338000			T	TNFRSF17	intestinal T-cell lymphoma								22	104					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9098546	9098546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9098546G>A	ENST00000377424.4	-	10	1297	c.1118C>T	c.(1117-1119)cCa>cTa	p.P373L	SLC2A5_ENST00000536305.1_Missense_Mutation_p.P314L|SLC2A5_ENST00000535586.1_Missense_Mutation_p.P258L	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	373					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGATGTATGGCATCCAGGA	0.607000													10	17					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31541393	31541393	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:31541393C>T	ENST00000454783.1	+	4	799	c.541C>T	c.(541-543)Cta>Tta	p.L181L	LTA_ENST00000418386.2_Silent_p.L181L	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	181					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	GGGAGACCAGCTATCCACCCA	0.557000													64	222					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49663135	49663135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:49663135G>A	ENST00000249601.4	-	6	998	c.702C>T	c.(700-702)taC>taT	p.Y234Y	ARHGAP22_ENST00000417912.2_Silent_p.Y250Y|ARHGAP22_ENST00000374170.1_Intron|ARHGAP22_ENST00000417247.2_Silent_p.Y144Y|ARHGAP22_ENST00000374172.1_Silent_p.Y125Y|ARHGAP22_ENST00000435790.2_Silent_p.Y240Y	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	234	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GCTCCCGCAGGTACAGCTTCA	0.662000													7	24					0	0	1	0	0
PAXBP1	94104	broad.mit.edu	37	21	34123226	34123226	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:34123226A>G	ENST00000331923.4	-	10	1913		c.e10+1		PAXBP1_ENST00000290178.4_Splice_Site	NM_016631.3	NP_057715.2			PAX3 and PAX7 binding protein 1																		TAAATGTCTAACCTTTTTCCA	0.358000													31	58					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54967229	54967229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:54967229G>A	ENST00000243052.3	+	9	1363	c.927G>A	c.(925-927)atG>atA	p.M309I	PDE1B_ENST00000550620.1_Missense_Mutation_p.M289I|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Missense_Mutation_p.M268I	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	309	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						ATGATGAGATGAACATTTTCA	0.453000													17	73					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26906074	26906074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:26906074G>A	ENST00000231021.4	-	5	977	c.805C>T	c.(805-807)Ccc>Tcc	p.P269S		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	269	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTACTCTGGGGAAATCGAGGA	0.428000													56	171					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23866398	23866398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:23866398G>A	ENST00000405093.3	-	17	2101	c.2031C>T	c.(2029-2031)ccC>ccT	p.P677P	MYH6_ENST00000356287.3_Silent_p.P677P	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	677	Actin-binding.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCCGCTCATTGGGGATGATGC	0.552000													60	127					0	0	1	0	0
TM4SF4	7104	broad.mit.edu	37	3	149205458	149205458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:149205458C>T	ENST00000305354.4	+	3	1221	c.317C>T	c.(316-318)tCg>tTg	p.S106L		NM_004617.3	NP_004608.1	P48230	T4S4_HUMAN	transmembrane 4 L six family member 4	106						integral to membrane				large_intestine(3)|lung(4)|ovary(1)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCTGGATACTCGTTTATCATC	0.502000													7	76					0	0	1	0	0
BARHL2	343472	broad.mit.edu	37	1	91177971	91177971	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:91177971C>T	ENST00000370445.4	-	3	1103	c.1062G>A	c.(1060-1062)cgG>cgA	p.R354R		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	354						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GCACCAGGGGCCGCTGCAGCT	0.687000													4	11					0	0	1	0	0
PEX14	5195	broad.mit.edu	37	1	10689751	10689751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:10689751C>T	ENST00000356607.4	+	9	921	c.841C>T	c.(841-843)Cac>Tac	p.H281Y	PEX14_ENST00000538836.1_Missense_Mutation_p.H217Y	NM_004565.2	NP_004556.1	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	281					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(3)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	13	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		GAAGGAGGGCCACAGCCCCGA	0.677000													7	16					0	0	1	0	0
FKBP9L	360132	broad.mit.edu	37	7	55755519	55755519	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:55755519C>T	ENST00000455909.1	-	0	487					NR_027340.1|NR_027342.1				FK506 binding protein 9-like											endometrium(1)|kidney(1)|lung(3)	5						GATCACTGTCCGTTTCTCGCC	0.517000													18	58					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207850802	207850802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:207850802C>T	ENST00000508064.2	+	2	226	c.166C>T	c.(166-168)Ccc>Tcc	p.P56S	CR1L_ENST00000530905.1_3'UTR	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	56	Sushi 1.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CTTTGAGTTTCCCATTGGGAC	0.468000													41	126					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48391447	48391447	+	Missense_Mutation	SNP	G	G	A	rs1050861		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:48391447G>A	ENST00000380518.3	-	7	637	c.473C>T	c.(472-474)cCt>cTt	p.P158L	COL2A1_ENST00000337299.6_Missense_Mutation_p.P89L	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	158			P -> L (in dbSNP:rs1050861).		axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	aggATTTCCAGGGGTCCCAGG	0.582000													20	64					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186338496	186338496	+	Missense_Mutation	SNP	C	C	T	rs145128363		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:186338496C>T	ENST00000411641.2	+	7	1100	c.881C>T	c.(880-882)cCc>cTc	p.P294L	AHSG_ENST00000273784.5_Missense_Mutation_p.P295L			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	294					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GCTGGCTCACCCCCAGACTCC	0.637000													39	179					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6167147	6167147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6167147C>T	ENST00000261405.5	-	14	1851	c.1597G>A	c.(1597-1599)Gac>Aac	p.D533N		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	533	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AGGAAGTCGTCGCCCTGGTTG	0.662000													34	86					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108013806	108013806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:108013806C>T	ENST00000280758.5	+	11	3024	c.2496C>T	c.(2494-2496)atC>atT	p.I832I	BTBD11_ENST00000420571.2_Silent_p.I713I|BTBD11_ENST00000490090.2_Silent_p.I832I|BTBD11_ENST00000357167.4_Silent_p.I369I	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	832						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CTTTGCGGATCGCCTTCCAGC	0.607000													5	30					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49176534	49176534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:49176534G>A	ENST00000307885.4	-	1	1378	c.684C>T	c.(682-684)ctC>ctT	p.L228L	ADCY6_ENST00000357869.3_Silent_p.L228L|ADCY6_ENST00000550422.1_Silent_p.L228L	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	228					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GGTCTGCTGCGAGAGCGCCCC	0.667000													3	11					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17774359	17774359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:17774359C>T	ENST00000428389.2	-	9	804	c.805G>A	c.(805-807)Ggc>Agc	p.G269S	UNC13A_ENST00000551649.1_Missense_Mutation_p.G181S|UNC13A_ENST00000552293.1_Missense_Mutation_p.G181S|UNC13A_ENST00000252773.7_Missense_Mutation_p.G181S|UNC13A_ENST00000519716.2_Missense_Mutation_p.G181S|UNC13A_ENST00000550896.1_Missense_Mutation_p.G181S			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	181					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						TCACCCCAGCCAAAATAATTC	0.537000													3	17					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71940997	71940997	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:71940997C>T	ENST00000541756.1	+	8	1077	c.147C>T	c.(145-147)tcC>tcT	p.S49S	INPPL1_ENST00000538751.1_Silent_p.S49S|INPPL1_ENST00000298229.2_Silent_p.S291S			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	291	SH2.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						ACATGAGCTCCACAGCACCCC	0.642000													9	55					0	0	1	0	0
DPYSL2	1808	broad.mit.edu	37	8	26435788	26435788	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:26435788G>A	ENST00000311151.5	+	1	430	c.18G>A	c.(16-18)aaG>aaA	p.K6K	DPYSL2_ENST00000521913.1_Intron	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	6					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		ATCAGGGGAAGAAAAATATTC	0.433000													27	104					0	0	1	0	0
TNFRSF4	7293	broad.mit.edu	37	1	1149139	1149139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:1149139G>A	ENST00000379236.3	-	2	176	c.172C>T	c.(172-174)Cgc>Tgc	p.R58C		NM_003327.3	NP_003318.1	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily, member 4	58					immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity			large_intestine(1)|lung(2)|urinary_tract(1)	4	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTCTGGGAGCGGCTGCAGCGG	0.697000													8	13					0	0	1	0	0
NUP37	79023	broad.mit.edu	37	12	102471194	102471194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:102471194G>A	ENST00000552283.1	-	7	767	c.628C>T	c.(628-630)Cca>Tca	p.P210S	NUP37_ENST00000251074.1_Missense_Mutation_p.P210S			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	210					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						GACATTAATGGCACTTGTTCT	0.403000													50	70					0	0	1	0	0
STPG1	90529	broad.mit.edu	37	1	24706163	24706163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24706163G>A	ENST00000374409.1	-	5	696	c.442C>T	c.(442-444)Cct>Tct	p.P148S	STPG1_ENST00000003583.8_Missense_Mutation_p.P101S|STPG1_ENST00000440416.1_Missense_Mutation_p.P101S|STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000337248.4_Missense_Mutation_p.P148S	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		TTTGGTGCAGGAGTTTCAAAC	0.383000													29	172					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25718726	25718726	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:25718726C>T	ENST00000520164.1	-	13	1718	c.1181G>A	c.(1180-1182)cGa>cAa	p.R394Q	EBF2_ENST00000408929.3_Missense_Mutation_p.R246Q|EBF2_ENST00000535548.1_Missense_Mutation_p.R125Q	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	394					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GTCTGCGGCTCGCTTCAAAAT	0.488000													35	68					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388446	48388446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:48388446G>A	ENST00000224600.4	-	1	2545	c.2432C>T	c.(2431-2433)tCt>tTt	p.S811F		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	811	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GTCAAAGACAGAATACAGGTG	0.607000													9	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082364	9082364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9082364G>A	ENST00000397910.4	-	1	9654	c.9451C>T	c.(9451-9453)Cct>Tct	p.P3151S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3152	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTTGGCAGGAACTGAAATA	0.443000													24	66					0	0	1	0	0
NUBP1	4682	broad.mit.edu	37	16	10850585	10850585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:10850585C>T	ENST00000283027.5	+	6	418	c.399C>T	c.(397-399)ttC>ttT	p.F133F	NUBP1_ENST00000433392.2_Silent_p.F122F|NUBP1_ENST00000571790.1_3'UTR	NM_002484.2	NP_002475.2	P53384	NUBP1_HUMAN	nucleotide binding protein 1	133					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			large_intestine(2)|lung(3)|ovary(1)|skin(4)	10						CAGTGGGCTTCCTGCTCAGCA	0.527000													6	61					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17446114	17446114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17446114C>T	ENST00000400588.1	-	7	1440	c.1333G>A	c.(1333-1335)Gag>Aag	p.E445K		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	445										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AAGGAGAGCTCATTGATGACC	0.567000													8	40					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411151	126411151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:126411151C>T	ENST00000394329.3	+	17	13187	c.13174C>T	c.(13174-13176)Ccc>Tcc	p.P4392S	FAT4_ENST00000335110.5_Missense_Mutation_p.P2633S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4392	Laminin G-like 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AAAAACAGATCCCTCAGTGAA	0.512000													104	243					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60695126	60695126	+	Missense_Mutation	SNP	G	G	A	rs144704995	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:60695126G>A	ENST00000005286.4	+	3	482	c.329G>A	c.(328-330)cGa>cAa	p.R110Q	TMEM132A_ENST00000453848.2_Missense_Mutation_p.R110Q	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	110						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GTCCCCCCTCGAGTCACTGAG	0.602000													78	168					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53157793	53157793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:53157793G>A	ENST00000296292.3	-	3	274	c.213C>T	c.(211-213)ctC>ctT	p.L71L	RFT1_ENST00000394738.3_Intron	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	71					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		TGCCCCCACTGAGACATGCTC	0.537000													19	46					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184765166	184765166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:184765166C>T	ENST00000367511.3	-	14	1925	c.1732G>A	c.(1732-1734)Gaa>Aaa	p.E578K	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	578					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GACACACTTTCACTGGGCAAG	0.463000													24	97					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520398	131520398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:131520398G>A	ENST00000423981.1	+	2	863	c.753G>A	c.(751-753)ggG>ggA	p.G251G	AMER3_ENST00000321420.4_Silent_p.G251G	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		CGGGTTGTGGGGAGGTGTTCG	0.637000													29	79					0	0	1	0	0
IGHV3-66	28412	broad.mit.edu	37	14	107131123	107131123	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:107131123G>A	ENST00000390632.2	-	0	336																											TGGAGATGGTGAATCGGCCCT	0.527000													24	201					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34181935	34181935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34181935G>A	ENST00000373381.4	-	20	3344	c.3168C>T	c.(3166-3168)ttC>ttT	p.F1056F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1016	Sushi 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AATCAGAGATGAAGCGGACCT	0.542000													9	67					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832380	61832380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:61832380C>T	ENST00000280772.1	-	37	8450	c.8259G>A	c.(8257-8259)gaG>gaA	p.E2753E	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2753					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTAGCTTGCTCTCCTGTATTT	0.403000													48	132					0	0	1	0	0
FOXK1	221937	broad.mit.edu	37	7	4798696	4798696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4798696C>T	ENST00000328914.4	+	6	1259	c.1259C>T	c.(1258-1260)tCg>tTg	p.S420L	FOXK1_ENST00000446823.1_Missense_Mutation_p.S257L	NM_001037165.1	NP_001032242.1	P85037	FOXK1_HUMAN	forkhead box K1	420					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		GCTCCAGCTTCGCCCACACAC	0.682000													37	80					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19492780	19492780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:19492780C>T	ENST00000328405.2	+	10	1975	c.1709C>T	c.(1708-1710)tCt>tTt	p.S570F	KCNH8_ENST00000537696.1_3'UTR	NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	570						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						ATCAAAACCTCTTTCTGTGCT	0.502000													39	83					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55880415	55880415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:55880415G>A	ENST00000521992.1	-	14	1908	c.1763C>T	c.(1762-1764)tCc>tTc	p.S588F	CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000290567.9_Missense_Mutation_p.S559F|CES5A_ENST00000518005.1_Missense_Mutation_p.S453F|CES5A_ENST00000520435.1_Missense_Mutation_p.S529F|CES5A_ENST00000319165.9_Missense_Mutation_p.S509F	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	559						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GAAAGTTAAGGAAGAAAGAGG	0.483000													51	153					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73142151	73142151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:73142151C>T	ENST00000545377.1	+	12	1662	c.1486C>T	c.(1486-1488)Cac>Tac	p.H496Y	ARHGEF28_ENST00000296794.6_Missense_Mutation_p.H496Y|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.H183Y|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.H496Y|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.H496Y|ARHGEF28_ENST00000513841.1_3'UTR|ARHGEF28_ENST00000426542.2_Missense_Mutation_p.H496Y|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.H496Y	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		TGAGCCATCCCACATCTGTTA	0.483000													14	44					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228860316	228860316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228860316C>T	ENST00000392056.3	-	8	4589	c.4543G>A	c.(4543-4545)Gag>Aag	p.E1515K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E1515K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1515						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CCTGTGCTCTCCTCGCTGCTG	0.572000													52	92					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114136163	114136163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:114136163C>T	ENST00000356116.1	+	1	208	c.96C>T	c.(94-96)agC>agT	p.S32S	ACSL5_ENST00000433418.1_5'UTR|ACSL5_ENST00000479936.1_Intron|ACSL5_ENST00000393081.1_Intron|ACSL5_ENST00000354273.4_5'UTR|ACSL5_ENST00000354655.4_Intron	NM_016234.3	NP_057318.2	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	0					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		AGCCGGGAAGCCCCCATTCAC	0.602000													15	108					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3140824	3140824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:3140824G>A	ENST00000263650.7	-	7	803	c.644C>T	c.(643-645)cCc>cTc	p.P215L	OSBPL5_ENST00000525498.1_Missense_Mutation_p.P126L|OSBPL5_ENST00000389989.3_Missense_Mutation_p.P147L|OSBPL5_ENST00000348039.5_Missense_Mutation_p.P147L|OSBPL5_ENST00000542243.1_Intron	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	215	PH.				cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GCTGGGCAGGGGCTGTGTGAT	0.642000													32	58					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101671417	101671417	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:101671417C>T	ENST00000360264.3	+	3	234	c.214C>T	c.(214-216)Caa>Taa	p.Q72*	CUX1_ENST00000292535.7_Nonsense_Mutation_p.Q61*|CUX1_ENST00000550008.2_Nonsense_Mutation_p.Q61*|CUX1_ENST00000556210.1_Nonsense_Mutation_p.Q61*|CUX1_ENST00000549414.2_Nonsense_Mutation_p.Q61*|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Nonsense_Mutation_p.Q61*|CUX1_ENST00000425244.2_Nonsense_Mutation_p.Q72*|CUX1_ENST00000292538.4_Nonsense_Mutation_p.Q72*|CUX1_ENST00000393824.3_Nonsense_Mutation_p.Q35*|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000437600.4_Nonsense_Mutation_p.Q72*	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	61					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						GAAGAGTTTCCAAGGAGAGGT	0.473000													7	73					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52710324	52710324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:52710324G>A	ENST00000293670.3	-	6	1031	c.969C>T	c.(967-969)acC>acT	p.T323T		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	323	Coil 2.|Rod.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTCCTCCTTGGTGCGGCGCA	0.597000													7	80					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108782046	108782046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108782046C>T	ENST00000232603.5	-	10	930	c.848G>A	c.(847-849)gGa>gAa	p.G283E	MORC1_ENST00000483760.1_Missense_Mutation_p.G283E	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	283					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTTAAATGCTCCTTTAAAAGA	0.303000													15	101					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178846735	178846735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:178846735G>A	ENST00000367635.3	+	9	1048	c.710G>A	c.(709-711)cGa>cAa	p.R237Q	RALGPS2_ENST00000477383.1_3'UTR|RALGPS2_ENST00000367634.2_Missense_Mutation_p.R237Q|RALGPS2_ENST00000324778.4_Missense_Mutation_p.R202Q	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	237	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						AATATCCTTCGAATAATTTCT	0.333000													13	46					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47400212	47400212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:47400212C>T	ENST00000457840.2	-	6	646	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000310638.4_Silent_p.R270R|CYP4A11_ENST00000371904.4_Silent_p.R271R|CYP4A11_ENST00000371905.1_Silent_p.R270R			Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	0					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	GTTGAGCCTTCCTCAGTTGGA	0.532000													29	89					0	0	1	0	0
AGFG1	3267	broad.mit.edu	37	2	228399602	228399602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228399602C>T	ENST00000310078.7	+	8	1326	c.1066C>T	c.(1066-1068)Cct>Tct	p.P356S	AGFG1_ENST00000409979.2_Missense_Mutation_p.P380S|AGFG1_ENST00000373671.3_Missense_Mutation_p.P316S|AGFG1_ENST00000409315.1_Intron|AGFG1_ENST00000409171.1_Missense_Mutation_p.P356S	NM_001135188.1|NM_004504.4	NP_001128660.1|NP_004495.2	P52594	AGFG1_HUMAN	ArfGAP with FG repeats 1	356					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(2)|ovary(1)|prostate(1)|skin(4)|stomach(1)	18						AGGTAAAGCTCCTGTTGGTTC	0.448000													30	90					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48201473	48201473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:48201473G>A	ENST00000394747.1	-	28	4339	c.3990C>T	c.(3988-3990)ctC>ctT	p.L1330L	ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000394748.1_Silent_p.L1330L|ABCC11_ENST00000353782.5_Silent_p.L1292L|ABCC11_ENST00000356608.2_Silent_p.L1330L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1330	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GGGCAATGACGAGCACGGTGC	0.567000													35	83					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965699	35965699	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35965699G>A	ENST00000274278.3	-	4	989	c.632C>T	c.(631-633)tCc>tTc	p.S211F	UGT3A1_ENST00000333811.4_Missense_Mutation_p.S157F|UGT3A1_ENST00000507113.1_Missense_Mutation_p.S177F|UGT3A1_ENST00000503189.1_Missense_Mutation_p.S211F|UGT3A1_ENST00000513233.1_Intron	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	211						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGGCTCCTGGAGAAACTAAA	0.463000													45	79					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76939021	76939021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:76939021G>A	ENST00000373344.5	-	9	1941	c.1727C>T	c.(1726-1728)tCa>tTa	p.S576L	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.S538L	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	576					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TGTAGTTTTTGATTTAATACC	0.358000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						43	165					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489689	237489689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:237489689C>T	ENST00000272928.3	+	2	891	c.581C>T	c.(580-582)aCc>aTc	p.T194I		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		AACAATGAGACCTACTGCCGG	0.587000													33	112					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161015120	161015120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:161015120C>T	ENST00000447678.1	-	23	3619	c.3499G>A	c.(3499-3501)Gat>Aat	p.D1167N	LPA_ENST00000316300.5_Missense_Mutation_p.D1167N	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3675	Kringle 11.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGGTAGCAATCCTGGACCCCG	0.478000													43	69					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27699589	27699589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:27699589G>A	ENST00000260570.3	-	14	1433	c.1330C>T	c.(1330-1332)Cgt>Tgt	p.R444C	IFT172_ENST00000416524.2_Missense_Mutation_p.R423C|IFT172_ENST00000359466.6_Missense_Mutation_p.R444C	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	444					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TCATTAATACGAACACTGAAA	0.373000													29	63					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967191	41967191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:41967191C>T	ENST00000298919.7	+	10	2218	c.1830C>T	c.(1828-1830)ctC>ctT	p.L610L	PDZRN4_ENST00000539469.2_Silent_p.L612L|PDZRN4_ENST00000402685.2_Silent_p.L870L			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	870							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AGAGTCAGCTCAGCTTGGTGA	0.468000													49	95					0	0	1	0	0
HBBP1	3044	broad.mit.edu	37	11	5264417	5264417	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:5264417G>A	ENST00000454892.1	-	0	79					NR_001589.1																						GGTCATCCGTGAGCATAACAG	0.498000													7	27					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272026	52272026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:52272026C>T	ENST00000598776.1	+	2	887	c.115C>T	c.(115-117)Ctc>Ttc	p.L39F	FPR2_ENST00000340023.6_Missense_Mutation_p.L39F|FPR2_ENST00000598953.1_Missense_Mutation_p.L39F	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	39					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity	p.L39F(1)		endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						CACCTTTGTCCTCGGGGTCCT	0.552000													23	77					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	71114247	71114247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:71114247G>A	ENST00000396396.1	+	10	1813	c.1584G>A	c.(1582-1584)agG>agA	p.R528R		NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	528					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						GCTACGAGAGGGATCCCAGCG	0.577000													27	69					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114289764	114289764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:114289764G>A	ENST00000309235.5	+	2	247	c.89G>A	c.(88-90)aGa>aAa	p.R30K	ZNF483_ENST00000374374.3_Missense_Mutation_p.R30K|ZNF483_ENST00000355824.3_Missense_Mutation_p.R30K|ZNF483_ENST00000358151.4_Missense_Mutation_p.R30K	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	30					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GAGGTCCCAAGAGTGGTTACT	0.458000													41	56					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134108468	134108468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134108468C>T	ENST00000220616.4	+	43	7463	c.7423C>T	c.(7423-7425)Cct>Tct	p.P2475S	SLA_ENST00000338087.5_Intron|SLA_ENST00000518565.1_Intron|TG_ENST00000542445.1_Missense_Mutation_p.P845S|SLA_ENST00000524345.1_Intron|TG_ENST00000519543.1_Missense_Mutation_p.P608S|TG_ENST00000377869.1_Missense_Mutation_p.P2418S|SLA_ENST00000517648.1_Intron|SLA_ENST00000395352.3_Intron	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2475					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CGTGAGTGGCCCTTTCCACTA	0.502000													75	160					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418518	8418518	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:8418518G>A	ENST00000337907.3	-	21	4711	c.4077C>T	c.(4075-4077)gcC>gcT	p.A1359A	RERE_ENST00000476556.1_Silent_p.A805A|RERE_ENST00000377464.1_Silent_p.A1091A|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Silent_p.A1359A	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1359					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGTGGGGCCCGGCGGTCGGGG	0.701000													4	15					0	0	1	0	0
KRT27	342574	broad.mit.edu	37	17	38935980	38935980	+	Missense_Mutation	SNP	C	C	A	rs76225348	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:38935980C>A	ENST00000301656.3	-	4	858	c.818G>T	c.(817-819)aGg>aTg	p.R273M		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	273	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				CTCCGCGTCCCTGCGGTTCTG	0.642000													11	20					2.27111e-07	2.27712e-07	1	1	0
KIAA1024	23251	broad.mit.edu	37	15	79760663	79760663	+	Silent	SNP	C	C	T	rs151300850	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:79760663C>T	ENST00000305428.3	+	4	2763	c.2688C>T	c.(2686-2688)atC>atT	p.I896I		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	896						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CTGCTCTGATCGCTGCTGCGG	0.458000													9	42					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139942061	139942061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:139942061G>A	ENST00000357560.4	-	5	818	c.375C>T	c.(373-375)ggC>ggT	p.G125G	APBB3_ENST00000508496.2_5'UTR|APBB3_ENST00000511201.2_Silent_p.G125G|APBB3_ENST00000507279.1_5'UTR|APBB3_ENST00000412920.3_Silent_p.G125G|APBB3_ENST00000354402.5_Silent_p.G125G|APBB3_ENST00000356738.2_Silent_p.G125G|APBB3_ENST00000358580.5_Silent_p.G125G	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	125	PID 1.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCTACCCAGCCCAGAGAGC	0.572000													70	203					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34235552	34235552	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:34235552G>A	ENST00000587132.1	-	0	2475																											TTTGGGCTGAGATCAATACAT	0.478000													22	44					0	0	1	0	0
ZNF564	163050	broad.mit.edu	37	19	12639443	12639443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:12639443G>A	ENST00000339282.7	-	2	267	c.71C>T	c.(70-72)tCc>tTc	p.S24F	CTD-2192J16.20_ENST00000593682.1_3'UTR|ZNF709_ENST00000428311.1_Intron	NM_144976.3	NP_659413.1			zinc finger protein 564											endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						TTTCTTCTGGGAAGGATCCAG	0.463000													51	124					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57136782	57136782	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:57136782C>T	ENST00000439986.4	-	4	360	c.323G>A	c.(322-324)cGa>cAa	p.R108Q	CCBE1_ENST00000398179.2_5'UTR	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	108					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				ACACAGCACTCGGCCAAAGTT	0.522000													52	111					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65396365	65396365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:65396365C>T	ENST00000355703.3	+	24	4426	c.3887C>T	c.(3886-3888)gCc>gTc	p.A1296V		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1296						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CTAGGCAGTGCCGTCTTCATC	0.637000													11	23					0	0	1	0	0
WNT2B	7482	broad.mit.edu	37	1	113058976	113058976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113058976G>A	ENST00000369684.4	+	3	1103	c.618G>A	c.(616-618)aaG>aaA	p.K206K	WNT2B_ENST00000478360.1_3'UTR|WNT2B_ENST00000369686.4_Silent_p.K187K|WNT2B_ENST00000256640.5_Silent_p.K114K	NM_024494.2	NP_078613.1	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B	206					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGATGCCAAGGAGAAGAGGC	0.537000													6	86					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46825915	46825915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:46825915C>T	ENST00000283296.7	-	17	4013	c.3725G>A	c.(3724-3726)gGg>gAg	p.G1242E	GPR116_ENST00000456426.2_Missense_Mutation_p.G1100E|GPR116_ENST00000265417.7_Missense_Mutation_p.G1242E|GPR116_ENST00000545669.1_Missense_Mutation_p.G671E|GPR116_ENST00000362015.4_Missense_Mutation_p.G1242E	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1242					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			AAGGTTGGTCCCTGGGAACAC	0.488000													27	67					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42297140	42297140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:42297140C>T	ENST00000399518.3	-	5	1048	c.562G>A	c.(562-564)Gag>Aag	p.E188K	PLA2G4E_ENST00000413860.2_Missense_Mutation_p.E159K	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	170					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		ACTCACCTCTCCTCCAGCAGG	0.622000													3	19					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78516338	78516338	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:78516338G>A	ENST00000278550.7	-	15	2640	c.2179_splice	c.e15+1	p.I726_splice		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TGCATTTACCGATAGAACAGT	0.552000													3	16					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35563557	35563557	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:35563557G>A	ENST00000262878.4	-	4	583	c.384C>T	c.(382-384)ctC>ctT	p.L128L	SAMHD1_ENST00000373694.5_5'UTR	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	128					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				GGAGAGGGTGGAGCTCAATGT	0.398000													37	77					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34164539	34164539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:34164539C>T	ENST00000373381.4	-	24	3915	c.3739G>A	c.(3739-3741)Gaa>Aaa	p.E1247K	CSMD2_ENST00000373380.1_Missense_Mutation_p.E120K|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1207	Sushi 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTGATGAGTTCAAAGCCTGGT	0.512000													4	39					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10267156	10267156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:10267156G>A	ENST00000340748.4	-	17	1497	c.1262C>T	c.(1261-1263)cCc>cTc	p.P421L	DNMT1_ENST00000540357.1_Missense_Mutation_p.P421L|DNMT1_ENST00000359526.4_Missense_Mutation_p.P437L			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	421	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GGTGTCGATGGGACACAGGTG	0.473000													27	49					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21063133	21063133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:21063133G>A	ENST00000261383.3	-	29	4095	c.4096C>T	c.(4096-4098)Caa>Taa	p.Q1366*	DNAH3_ENST00000415178.1_Nonsense_Mutation_p.Q1366*	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1366	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GAGATCCATTGGAAATCATTC	0.527000													43	91					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17449880	17449880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:17449880G>A	ENST00000302539.4	-	14	2121	c.1996C>T	c.(1996-1998)Ctg>Ttg	p.L666L	ABCC8_ENST00000389817.3_Silent_p.L666L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	666					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTGGGGACCAGGCTCTGCAGT	0.657000													25	122					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45554637	45554637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45554637C>T	ENST00000415258.1	+	15	1912	c.1771C>T	c.(1771-1773)Cat>Tat	p.H591Y	LARS2_ENST00000467936.1_3'UTR|LARS2_ENST00000265537.3_Missense_Mutation_p.H591Y|LARS2_ENST00000414984.1_Missense_Mutation_p.H548Y			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	591					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	GGAGCCTTTTCATAAGCTGCT	0.512000													15	154					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34502056	34502056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:34502056C>T	ENST00000374012.3	+	12	1891	c.1762C>T	c.(1762-1764)Cat>Tat	p.H588Y	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	588					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GCCAGGGGTCCATATGAGCCC	0.537000													30	61					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	6031893	6031893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6031893C>T	ENST00000546188.1	-	2	159	c.88G>A	c.(88-90)Gga>Aga	p.G30R	ANO2_ENST00000356134.5_Missense_Mutation_p.G30R|ANO2_ENST00000327087.8_Missense_Mutation_p.G30R			Q9NQ90	ANO2_HUMAN	anoctamin 2	34						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CACTGCTGTCCATGTTTGGGG	0.662000													4	12					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423451	56423451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:56423451C>T	ENST00000588751.1	-	5	1756	c.1732G>A	c.(1732-1734)Gaa>Aaa	p.E578K	NLRP13_ENST00000342929.3_Missense_Mutation_p.E578K			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	578							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAGTAGGCTTCTTTGTCAAGC	0.418000													43	108					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204335010	204335010	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:204335010G>A	ENST00000374493.3	-	5	839	c.840C>T	c.(838-840)tcC>tcT	p.S280S	RAPH1_ENST00000374488.2_Silent_p.S253S|RAPH1_ENST00000374489.2_Intron|RAPH1_ENST00000319170.5_Intron|RAPH1_ENST00000439222.1_Silent_p.S253S|RAPH1_ENST00000453034.1_Silent_p.S280S|RAPH1_ENST00000418114.1_Intron|RAPH1_ENST00000457812.1_Intron|RAPH1_ENST00000419464.1_Intron|RAPH1_ENST00000423104.1_Intron|RAPH1_ENST00000308091.4_Silent_p.S280S			Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	241	Ras-associating.				cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TCAGAAGAAGGGAGGTTTCCC	0.383000													34	113					0	0	1	0	0
POU2AF1	5450	broad.mit.edu	37	11	111229584	111229584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:111229584C>T	ENST00000393067.3	-	2	590	c.76G>A	c.(76-78)Gag>Aag	p.E26K		NM_006235.2	NP_006226.2	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	26					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|kidney(2)|lung(2)	5		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		TTCACTGGCTCCTTCACACGG	0.632000			T	BCL6	NHL								10	33					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12954982	12954982	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:12954982G>A	ENST00000235347.4	-	3	380	c.301C>T	c.(301-303)Caa>Taa	p.Q101*		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	101										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCCAGCACTTGAAGTTTCCAC	0.527000													50	316					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186670720	186670720	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:186670720G>A	ENST00000343098.5	+	17	16954	c.16954G>A	c.(16954-16956)Gaa>Aaa	p.E5652K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E5563K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TAATAATAATGAAATTGAGAA	0.269000													29	68					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4281527	4281527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:4281527C>T	ENST00000404826.2	+	43	6372	c.6233C>T	c.(6232-6234)tCc>tTc	p.S2078F	SDK1_ENST00000389531.3_Missense_Mutation_p.S2058F|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2078					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCACCTTCTCCAAGAAGAAC	0.632000													9	36					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818882	159818882	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:159818882G>A	ENST00000497452.1	-	0	517																											gggagaaaacggagaagagtt	0.458000													116	368					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94671197	94671197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:94671197C>T	ENST00000260526.6	-	6	735	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.E185K	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	185					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTACCTTTTTCACTGGATGAG	0.323000													38	98					0	0	1	0	0
HCAR3	8843	broad.mit.edu	37	12	123200699	123200699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:123200699C>T	ENST00000528880.2	-	1	740	c.586G>A	c.(586-588)Gag>Aag	p.E196K	HCAR1_ENST00000356987.2_Intron	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	196						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	AGGAAGAACTCCAGGAGGAAC	0.532000													22	78					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544533	186544533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:186544533C>T	ENST00000431808.1	-	14	2601	c.2038G>A	c.(2038-2040)Gaa>Aaa	p.E680K	SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.E780K|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.E584K|SORBS2_ENST00000284776.7_Missense_Mutation_p.E680K			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	680						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TCGGTGTTTTCGTGTCTGGCT	0.522000													43	153					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9098032	9098032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:9098032G>A	ENST00000377424.4	-	11	1405	c.1226C>T	c.(1225-1227)cCa>cTa	p.P409L	SLC2A5_ENST00000536305.1_Missense_Mutation_p.P350L|SLC2A5_ENST00000535586.1_Missense_Mutation_p.P294L	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	409					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGGCAGATGGCCGAGAGGA	0.647000													10	24					0	0	1	0	0
RHOV	171177	broad.mit.edu	37	15	41165381	41165381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41165381C>T	ENST00000220507.4	-	3	735	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K		NM_133639.3	NP_598378.3	Q96L33	RHOV_HUMAN	ras homolog family member V	196					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding			central_nervous_system(1)|large_intestine(1)	2		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		TCAAATACTTCCTTCAAGTTC	0.592000													39	85					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730425	140730425	+	Missense_Mutation	SNP	G	G	A	rs36001111		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140730425G>A	ENST00000523390.1	+	1	598	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTAGACAGGGAACATCAGAG	0.493000													18	115					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25458674	25458674	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25458674C>T	ENST00000424208.1	+	0	2631				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						AGCCAGTTTCCCAGCCCCTGG	0.582000													9	18					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3777936	3777936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3777936G>A	ENST00000262367.5	-	31	7921	c.7112C>T	c.(7111-7113)cCt>cTt	p.P2371L	CREBBP_ENST00000382070.3_Missense_Mutation_p.P2333L	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	2371					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGTGGCGAAGGCTGGGGCTG	0.642000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						10	90					0	0	1	0	0
DDB2	1643	broad.mit.edu	37	11	47256923	47256923	+	Missense_Mutation	SNP	C	C	T	rs145822896		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:47256923C>T	ENST00000256996.4	+	7	1178	c.983C>T	c.(982-984)cCg>cTg	p.P328L	DDB2_ENST00000378603.3_Missense_Mutation_p.P264L|DDB2_ENST00000378601.3_3'UTR|DDB2_ENST00000378600.3_Intron	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	328					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						GGCCTGATCCCGCACCCTCAC	0.622000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				23	35					0	0	1	0	0
PTPN6	5777	broad.mit.edu	37	12	7064026	7064026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7064026G>A	ENST00000456013.1	+	4	627	c.385G>A	c.(385-387)Gag>Aag	p.E129K	PTPN6_ENST00000447931.2_Missense_Mutation_p.E90K|PTPN6_ENST00000318974.9_Missense_Mutation_p.E129K|PTPN6_ENST00000399448.1_Missense_Mutation_p.E131K	NM_080549.3	NP_536859.1	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type 6	129	SH2 2.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity	p.E129K(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|prostate(3)	18						GGCCAAGGGCGAGCCCTGGAC	0.637000													6	64					0	0	1	0	0
PRKY	5616	broad.mit.edu	37	Y	7239831	7239831	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:7239831C>T	ENST00000528056.1	+	0	1282					NR_028062.1															large_intestine(2)|lung(3)|skin(1)	6						CTTCCAACTTCGAAACTTACC	0.527000													14	8					0	0	1	0	0
XPNPEP3	63929	broad.mit.edu	37	22	41265035	41265035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:41265035C>T	ENST00000357137.4	+	2	181	c.97C>T	c.(97-99)Ctt>Ttt	p.L33F	XPNPEP3_ENST00000541156.1_Missense_Mutation_p.L33F|XPNPEP3_ENST00000414396.1_Missense_Mutation_p.L33F|XPNPEP3_ENST00000544094.1_Missense_Mutation_p.L10F	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	33					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						AAGGTACTCCCTTCAGCCTGT	0.438000													56	111					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060569	9060569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9060569G>A	ENST00000397910.4	-	3	27080	c.26877C>T	c.(26875-26877)ctC>ctT	p.L8959L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8961	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGCTCTGGGAGGCCTGGAT	0.463000													52	144					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20269523	20269523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:20269523G>A	ENST00000245957.5	+	23	3143	c.3067G>A	c.(3067-3069)Gag>Aag	p.E1023K	C20orf26_ENST00000377309.2_Intron	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	1023										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		GCCTGTGACCGAGCCACCAGC	0.483000													15	44					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56137941	56137941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:56137941C>T	ENST00000319441.4	+	4	760	c.596C>T	c.(595-597)cCt>cTt	p.P199L	PCK1_ENST00000543666.1_Intron|PCK1_ENST00000535860.1_Missense_Mutation_p.P67L	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	199					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GTGGGGTGCCCTCTGCCTTTA	0.527000													5	50					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86394637	86394637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:86394637G>A	ENST00000361669.2	+	2	1275	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	GRM3_ENST00000394720.2_Missense_Mutation_p.R57Q|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Missense_Mutation_p.R59Q|GRM3_ENST00000536043.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	59					synaptic transmission	integral to plasma membrane		p.R59Q(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GAATGTGGGCGAATCAATGAA	0.418000													29	117					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39969292	39969292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:39969292C>T	ENST00000321562.4	+	1	110	c.6C>T	c.(4-6)ttC>ttT	p.F2F		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	2					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GCACCATGTTCCCCGCGGGCC	0.731000													8	14					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113405329	113405329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:113405329G>A	ENST00000228928.7	+	13	2975	c.2796G>A	c.(2794-2796)cgG>cgA	p.R932R	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	932	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						AGCTACAACGGGACTTCATCA	0.572000													8	21					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43109528	43109528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:43109528C>T	ENST00000230419.4	+	11	1962	c.1741C>T	c.(1741-1743)Cgt>Tgt	p.R581C	PTK7_ENST00000481273.1_Missense_Mutation_p.R589C|PTK7_ENST00000345201.2_Missense_Mutation_p.R541C|PTK7_ENST00000349241.2_Missense_Mutation_p.R451C|PTK7_ENST00000352931.2_Missense_Mutation_p.R581C	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	581	Ig-like C2-type 6.|Ig-like C2-type 7.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GGGCCAGATTCGTGCCCATGT	0.657000													38	111					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509611	71509611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:71509611G>A	ENST00000396073.3	+	9	2749	c.2468G>A	c.(2467-2469)tGg>tAg	p.W823*	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	823					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AATCCAATATGGCATGAAGGT	0.438000													20	64					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76464764	76464764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:76464764C>T	ENST00000389840.5	-	55	8795	c.8671G>A	c.(8671-8673)Ggc>Agc	p.G2891S	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.G2900S					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCATTCATGCCAAGGGACTTG	0.552000													13	38					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205273193	205273193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:205273193C>T	ENST00000367157.3	-	7	1398	c.1272G>A	c.(1270-1272)gaG>gaA	p.E424E		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	424					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CCGGAGGGTCCTCCTGTACCC	0.627000													47	66					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981225	7981225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:7981225C>T	ENST00000328600.2	-	2	2095	c.1934G>A	c.(1933-1935)gGg>gAg	p.G645E		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	645							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTCCTCTGTCCCTCTGCCTTT	0.383000													13	41					0	0	1	0	0
KCNAB1	7881	broad.mit.edu	37	3	155861118	155861118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155861118G>A	ENST00000471742.1	+	1	368	c.151G>A	c.(151-153)Gca>Aca	p.A51T	KCNAB1_ENST00000389636.5_Intron|KCNAB1_ENST00000490337.1_Intron	NM_003471.3	NP_003462.2	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GCCCAGTGGAGCAGCCGAACA	0.512000													27	64					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179600700	179600700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179600700C>T	ENST00000589042.1	-	50	14697	c.14473G>A	c.(14473-14475)Gaa>Aaa	p.E4825K	TTN_ENST00000342992.6_Missense_Mutation_p.E3581K|TTN_ENST00000591111.1_Missense_Mutation_p.E4508K|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4508	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAATGGTTTCTATCACAGGA	0.463000													31	65					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137749945	137749945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:137749945G>A	ENST00000183605.5	+	5	974	c.748G>A	c.(748-750)Gag>Aag	p.E250K	CLDN18_ENST00000343735.4_Missense_Mutation_p.E250K	NM_016369.3	NP_057453.1	P56856	CLD18_HUMAN	claudin 18	250					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						CACAGAGGACGAGGTACAATC	0.517000													43	112					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2071147	2071147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:2071147C>T	ENST00000262113.4	+	29	3617	c.3476C>T	c.(3475-3477)aCc>aTc	p.T1159I	MYOM2_ENST00000523438.1_Missense_Mutation_p.T584I	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1159	Ig-like C2-type 4.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAGAAAGAAACCGTTTTCAAA	0.408000													8	79					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25304717	25304717	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25304717C>T	ENST00000549804.2	+	0	110				SNHG14_ENST00000384733.1_RNA																							AAAAAACATTCCTTGGAAAAG	0.502000													71	206					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21228515	21228515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:21228515G>A	ENST00000233242.1	-	26	11352	c.11225C>T	c.(11224-11226)tCa>tTa	p.S3742L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3742					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACAAGAACTGAATTTAGATC	0.383000													49	157					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045526	142045526	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:142045526C>T	ENST00000390392.3	+	0	165																											CCGCAGTCCCCATGGAAACGG	0.478000													45	150					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145806329	145806329	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:145806329G>A	ENST00000276826.5	-	2	614	c.413C>T	c.(412-414)tCc>tTc	p.S138F	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.S138F|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.S138F			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	138					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CTCCAGGGAGGAGCTGGTGCT	0.716000													4	18					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139717522	139717522	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:139717522C>T	ENST00000263552.6	+	16	1957	c.1419C>T	c.(1417-1419)ttC>ttT	p.F473F	TBXAS1_ENST00000448866.1_Silent_p.F472F|TBXAS1_ENST00000436047.2_Silent_p.F473F|TBXAS1_ENST00000414508.2_Intron|TBXAS1_ENST00000416849.2_Silent_p.F519F|TBXAS1_ENST00000425687.1_Silent_p.F405F|TBXAS1_ENST00000411653.1_Intron|TBXAS1_ENST00000458722.1_Silent_p.F518F|TBXAS1_ENST00000336425.5_Silent_p.F472F	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	472					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					ACCTGCCCTTCGGGGCCGGCC	0.682000													15	73					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179603955	179603955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:179603955C>T	ENST00000589042.1	-	48	14229	c.14005G>A	c.(14005-14007)Gaa>Aaa	p.E4669K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E4352K|TTN_ENST00000342175.6_Missense_Mutation_p.E4498K|TTN_ENST00000359218.5_Missense_Mutation_p.E4431K|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E4306K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4352	Ig-like 27.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATGGTCTTCGGTATTTACT	0.378000													10	28					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11004048	11004048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:11004048G>A	ENST00000324288.8	+	13	2953	c.2820G>A	c.(2818-2820)acG>acA	p.T940T	CIITA_ENST00000381835.5_Silent_p.T356T|CIITA_ENST00000537380.1_3'UTR	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	940			Missing (in BLS2).		interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						TCTCCAGGACGAGAAGTTCCT	0.567000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								5	20					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117554722	117554722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:117554722C>T	ENST00000374045.4	-	3	379	c.266G>A	c.(265-267)aGa>aAa	p.R89K		NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	89					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						TCCGTCTGCTCTAAGAGGTGC	0.488000													14	50					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206869967	206869967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:206869967G>A	ENST00000403263.1	-	11	2613	c.2209C>T	c.(2209-2211)Cgt>Tgt	p.R737C		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	737					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						GTAGCAGAACGGAGCAGGTTC	0.522000													15	48					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303883	151303883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:151303883G>A	ENST00000370323.4	-	4	526	c.210C>T	c.(208-210)acC>acT	p.T70T	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Silent_p.T70T	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	70										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCTCTGGGGTGCTTGGTA	0.532000													54	40					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35025869	35025869	+	Splice_Site	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:35025869T>C	ENST00000231420.6	-	9	1162	c.963_splice	c.e9+1	p.E321_splice		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	321					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding	p.E321G(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GCCACTTACTTCATCTGCAAT	0.512000													15	45					0	0	1	0	0
CALHM1	255022	broad.mit.edu	37	10	105218356	105218356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:105218356G>A	ENST00000329905.5	-	1	289	c.153C>T	c.(151-153)gcC>gcT	p.A51A	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	51						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						CCGCGCTGTAGGCTGCATTGT	0.612000													22	74					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81643776	81643776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:81643776G>A	ENST00000356860.3	-	13	1501	c.1163C>T	c.(1162-1164)tCa>tTa	p.S388L	MIR1255B1_ENST00000454066.1_RNA|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.S388L|CACNA2D1_ENST00000464354.1_5'UTR|MIR1255B1_ENST00000439234.1_RNA	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	388	VWFA.					voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTGACCAACTGAAAACGTGAA	0.308000													13	46					0	0	1	0	0
HINT1	3094	broad.mit.edu	37	5	130498346	130498346	+	Missense_Mutation	SNP	G	G	A	rs1802917		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:130498346G>A	ENST00000513012.1	-	2	220	c.170C>T	c.(169-171)cCc>cTc	p.P57L	HINT1_ENST00000506207.1_5'UTR|HINT1_ENST00000304043.5_Silent_p.S45S|HINT1_ENST00000508488.1_Silent_p.S45S|HINT1_ENST00000506908.1_Silent_p.S45S			P49773	HINT1_HUMAN	histidine triad nucleotide binding protein 1	0	HIT.				signal transduction	cytoplasm|cytoskeleton|nucleus	hydrolase activity|protein kinase C binding			endometrium(1)|large_intestine(1)|lung(3)	5		all_cancers(142;0.0452)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Adenosine monophosphate(DB00131)	GTGCTTGAGGGGAAATGTCAT	0.328000													17	81					0	0	1	0	0
TEX11	56159	broad.mit.edu	37	X	70080744	70080744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:70080744G>A	ENST00000395889.2	-	6	487	c.332C>T	c.(331-333)tCa>tTa	p.S111L	TEX11_ENST00000344304.3_Missense_Mutation_p.S111L|TEX11_ENST00000374333.2_Missense_Mutation_p.S96L	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	111							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					TGAGGCAAATGAGGCTTCACA	0.338000													21	13					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55110892	55110892	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:55110892C>T	ENST00000314721.2	+	1	266	c.216C>T	c.(214-216)tcC>tcT	p.S72S		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	72					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						CCATATATTCCACTGCCATGT	0.443000													67	189					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71125403	71125403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:71125403G>A	ENST00000299213.8	-	3	534	c.464C>T	c.(463-465)tCa>tTa	p.S155L		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	155	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						AAGGACCACTGAATACTTCAA	0.502000													24	80					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164393478	164393478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:164393478C>T	ENST00000280605.3	-	1	1569	c.1409G>A	c.(1408-1410)gGa>gAa	p.G470E		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	470						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAAGCACATTCCCTTGGTATT	0.468000													45	113					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6730251	6730251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6730251G>A	ENST00000329858.4	-	2	920	c.164C>T	c.(163-165)tCg>tTg	p.S55L	LPAR5_ENST00000431922.1_Missense_Mutation_p.S55L|LPAR5_ENST00000540335.1_5'UTR	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	55						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						GCTCACCACCGAGTGCACGCG	0.662000													5	28					0	0	1	0	0
MEF2B	100271849	broad.mit.edu	37	19	19257422	19257422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:19257422G>A	ENST00000409447.2	-	7	808	c.577C>T	c.(577-579)Cac>Tac	p.H193Y	MEF2BNB-MEF2B_ENST00000514819.3_Silent_p.S254S|MEF2B_ENST00000424583.2_Silent_p.S237S|MEF2B_ENST00000602424.2_Silent_p.S237S|MEF2BNB-MEF2B_ENST00000444486.3_Silent_p.S237S|MEF2B_ENST00000162023.5_Silent_p.S237S|MEF2B_ENST00000410050.1_Silent_p.S237S|MEF2B_ENST00000409224.1_Silent_p.S240S					myocyte enhancer factor 2B											breast(1)|haematopoietic_and_lymphoid_tissue(21)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			GAGTTGCAGTGGAGCAGGGGT	0.672000													7	18					0	0	1	0	0
INO80E	283899	broad.mit.edu	37	16	30012298	30012298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:30012298C>T	ENST00000563197.1	+	5	1350	c.333C>T	c.(331-333)tcC>tcT	p.S111S	INO80E_ENST00000567705.1_Silent_p.S111S|INO80E_ENST00000304516.7_Silent_p.S111S|INO80E_ENST00000567254.1_Silent_p.S111S	NM_173618.1	NP_775889.1	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	111	Pro-rich.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	6						CCAGCCTCTCCCTGCCTCCTT	0.657000													17	62					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983855	97983855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97983855G>A	ENST00000383696.2	+	1	768	c.727G>A	c.(727-729)Gaa>Aaa	p.E243K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TACAATCTTAGAAAAGAAGTC	0.343000													20	41					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38655274	38655274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:38655274G>A	ENST00000443581.1	-	6	856	c.663C>T	c.(661-663)ttC>ttT	p.F221F	SCN5A_ENST00000423572.2_Silent_p.F221F|SCN5A_ENST00000425664.1_Intron|SCN5A_ENST00000333535.4_Silent_p.F221F|SCN5A_ENST00000451551.2_Intron|SCN5A_ENST00000455624.2_Intron|SCN5A_ENST00000449557.2_Silent_p.F221F|SCN5A_ENST00000450102.2_Intron|SCN5A_ENST00000413689.1_Intron|SCN5A_ENST00000414099.2_Intron	NM_000335.4|NM_198056.2	NP_000326.2|NP_932173.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	221					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGAGGACTCGGAAGGTGCGTA	0.483000													7	18					0	0	1	0	0
VASH1	22846	broad.mit.edu	37	14	77229182	77229182	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:77229182G>A	ENST00000167106.4	+	1	651	c.18G>A	c.(16-18)aaG>aaA	p.K6K	VASH1_ENST00000554237.1_Silent_p.K6K	NM_014909.4	NP_055724.1	Q7L8A9	VASH1_HUMAN	vasohibin 1	6					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space				breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|urinary_tract(3)	10			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		GGGGGAAGAAGGTGGCTGGGG	0.652000													6	4					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009648	9009648	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9009648C>T	ENST00000397910.4	-	39	39281	c.39078G>A	c.(39076-39078)gaG>gaA	p.E13026E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13028	SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACGCATGTCCTCCCCATACT	0.542000													57	124					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101598755	101598755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:101598755C>T	ENST00000335681.5	+	16	1830	c.1545C>T	c.(1543-1545)atC>atT	p.I515I	NPAS2_ENST00000542504.1_Silent_p.I580I	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	515					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GGACGCGGATCCTGCAGGCCA	0.547000													4	53					0	0	1	0	0
KHDC3L	154288	broad.mit.edu	37	6	74073372	74073372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:74073372C>T	ENST00000370367.3	+	3	496	c.443C>T	c.(442-444)tCg>tTg	p.S148L		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		ACGCAGCGTTCGGTGGAGGTC	0.677000													28	31					0	0	1	0	0
TMCO5A	145942	broad.mit.edu	37	15	38230404	38230404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:38230404C>T	ENST00000558158.1	+	6	515	c.361C>T	c.(361-363)Cca>Tca	p.P121S	TMCO5A_ENST00000319669.4_Missense_Mutation_p.P121S|TMCO5A_ENST00000540944.1_Missense_Mutation_p.P121S|TMCO5A_ENST00000559502.1_Missense_Mutation_p.P121S			Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	121						integral to membrane				central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	15						ACAAAGCAGTCCAGATGGAGC	0.333000													6	9					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883024	228883024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:228883024C>T	ENST00000392056.3	-	7	2592	c.2546G>A	c.(2545-2547)aGt>aAt	p.S849N	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S849N	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	849						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCATTCTCACTGTGATGAGG	0.498000													42	88					0	0	1	0	0
USP5	8078	broad.mit.edu	37	12	6966849	6966849	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:6966849C>T	ENST00000229268.8	+	7	878	c.826C>T	c.(826-828)Ctg>Ttg	p.L276L	USP5_ENST00000389231.5_Silent_p.L276L	NM_001098536.1	NP_001092006.1	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 (isopeptidase T)	276					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(6)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|skin(2)|urinary_tract(2)	36						GGCTGAGCACCTGTCCCACTT	0.547000													43	98					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123457790	123457790	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:123457790G>A	ENST00000360772.3	-	8	920	c.542C>T	c.(541-543)tCc>tTc	p.S181F	MYLK_ENST00000360304.3_Missense_Mutation_p.S181F|MYLK_ENST00000475616.1_Missense_Mutation_p.S181F|MYLK_ENST00000346322.5_Missense_Mutation_p.S181F|MYLK_ENST00000359169.1_Missense_Mutation_p.S181F			Q15746	MYLK_HUMAN	myosin light chain kinase	181	Ig-like C2-type 2.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GATCTTGCAGGAGAATCGTCC	0.572000													7	27					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432457	30432457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:30432457C>T	ENST00000375978.3	-	1	963	c.889G>A	c.(889-891)Gaa>Aaa	p.E297K		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	297					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						ACCCAGGGTTCCTTGTGGTCA	0.652000													13	31					0	0	1	0	0
MBNL2	10150	broad.mit.edu	37	13	98018783	98018783	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:98018783C>T	ENST00000345429.6	+	8	1846	c.1065C>T	c.(1063-1065)ttC>ttT	p.F355F	MBNL2_ENST00000397601.1_Intron|MBNL2_ENST00000376673.3_Intron|MBNL2_ENST00000445661.2_Intron|MBNL2_ENST00000343600.4_Intron	NM_144778.3	NP_659002.1	Q5VZF2	MBNL2_HUMAN	muscleblind-like splicing regulator 2	165					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			GTGTCCCCTTCGCAGCAACAG	0.463000													29	123					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540465	133540465	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:133540465C>T	ENST00000409261.1	-	14	4292	c.3919G>A	c.(3919-3921)Gag>Aag	p.E1307K	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.E1307K	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1307							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTGCCTCTCTCGGCGGTATTG	0.567000													26	63					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37353567	37353567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:37353567G>A	ENST00000217420.1	+	1	463	c.200G>A	c.(199-201)gGa>gAa	p.G67E		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	67					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	AAAGCCGAGGGAGAGCCCTGC	0.677000													5	42					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053935	133053935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:133053935G>A	ENST00000262283.5	-	8	868	c.769C>T	c.(769-771)Ccc>Tcc	p.P257S	OC90_ENST00000443356.2_Missense_Mutation_p.P61S|OC90_ENST00000254627.3_Missense_Mutation_p.P61S|OC90_ENST00000603859.1_Missense_Mutation_p.P61S			Q02509	OC90_HUMAN	otoconin 90	61					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GTGAAGTGGGGGCCCAGGCAA	0.587000													10	16					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89531723	89531723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:89531723C>T	ENST00000329758.1	-	8	1262	c.934G>A	c.(934-936)Gga>Aga	p.G312R	TRIM49_ENST00000532501.2_Missense_Mutation_p.G235R	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	312	B30.2/SPRY.					intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TGGTCACATCCAATACACATG	0.373000													18	59					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66209075	66209075	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:66209075C>T	ENST00000360689.5	+	11	3402	c.1675C>T	c.(1675-1677)Cga>Tga	p.R559*	FUT8_ENST00000394585.1_Nonsense_Mutation_p.R559*|FUT8_ENST00000557164.1_Nonsense_Mutation_p.R396*|FUT8_ENST00000394586.2_Nonsense_Mutation_p.R559*|FUT8_ENST00000358307.2_Nonsense_Mutation_p.R430*|FUT8_ENST00000417683.1_Nonsense_Mutation_p.R153*	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	559	SH3.				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		CTACAAAGTTCGAGAGAAGAT	0.448000													21	59					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237791148	237791148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237791148G>A	ENST00000366574.2	+	41	6525	c.6208G>A	c.(6208-6210)Gct>Act	p.A2070T	RYR2_ENST00000542537.1_Missense_Mutation_p.A2054T|RYR2_ENST00000360064.6_Missense_Mutation_p.A2068T	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2070	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTCCGATGGGCTCAGGAGTC	0.493000													6	27					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113638980	113638980	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:113638980C>T	ENST00000361127.4	+	8	1282	c.1084C>T	c.(1084-1086)Cag>Tag	p.Q362*		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	362						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TTCCAATCTTCAGACATTGTA	0.323000													37	100					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217124264	217124264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:217124264C>T	ENST00000273067.4	-	4	2770	c.1004G>A	c.(1003-1005)cGg>cAg	p.R335Q		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	335						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		TGAGGAGGTCCGGGGGTTGGT	0.617000													10	30					0	0	1	0	0
AC005754.7	0	broad.mit.edu	37	5	140480201	140480201	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140480201G>A	ENST00000607216.1	-	0	208																											TCAGCTTGGCGACATTCCCTG	0.512000													21	45					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47260154	47260154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr13:47260154C>T	ENST00000311191.6	+	5	1029	c.800C>T	c.(799-801)cCt>cTt	p.P267L	LRCH1_ENST00000389797.3_Missense_Mutation_p.P267L|LRCH1_ENST00000389798.3_Missense_Mutation_p.P267L	NM_001164213.1	NP_001157685.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	267										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GAGAATAACCCTCTGCAGTCT	0.473000													18	55					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23197734	23197734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23197734C>T	ENST00000300061.2	+	2	285	c.142C>T	c.(142-144)Cgc>Tgc	p.R48C		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	48					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	CGTGGTGTCCCGCGGCCGTCT	0.637000													10	46					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100386959	100386959	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:100386959G>A	ENST00000542585.1	+	0	7492				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTGGTGGAAGGAAAAATGCAG	0.537000													35	65					0	0	1	0	0
SLC2A14	144195	broad.mit.edu	37	12	7966949	7966949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:7966949C>T	ENST00000543909.1	-	16	2285	c.1526G>A	c.(1525-1527)aGc>aAc	p.S509N	SLC2A14_ENST00000340749.5_Missense_Mutation_p.S486N|SLC2A14_ENST00000431042.2_Missense_Mutation_p.S486N|SLC2A14_ENST00000396589.2_Missense_Mutation_p.S509N|SLC2A14_ENST00000535295.1_Missense_Mutation_p.S400N|SLC2A14_ENST00000542505.1_Missense_Mutation_p.S150N|SLC2A14_ENST00000539924.1_Missense_Mutation_p.S524N|SLC2A14_ENST00000542546.1_Missense_Mutation_p.S400N			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	509					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		AGGCTCGATGCTGTTCATCCC	0.577000													31	276					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056563	9056563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:9056563G>A	ENST00000397910.4	-	3	31086	c.30883C>T	c.(30883-30885)Cca>Tca	p.P10295S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10297	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGCTCGTGGAACTCCAGTG	0.522000													21	79					0	0	1	0	0
EXT1	2131	broad.mit.edu	37	8	118819608	118819608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:118819608G>A	ENST00000378204.2	-	9	2537	c.1731C>T	c.(1729-1731)ttC>ttT	p.F577F		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	577					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			CTGTGAAGGCGAAATCCACCT	0.483000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				15	48					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116064542	116064542	+	Missense_Mutation	SNP	G	G	A	rs148589522		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:116064542G>A	ENST00000369271.3	-	11	1520	c.1220C>T	c.(1219-1221)cCc>cTc	p.P407L	AFAP1L2_ENST00000304129.4_Missense_Mutation_p.P407L|AFAP1L2_ENST00000545353.1_Missense_Mutation_p.P460L	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	407	PH 2.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GTCGGGGCTGGGGTCTGGGAC	0.667000													7	62					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189830	124189830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:124189830C>T	ENST00000357438.2	-	1	354	c.264G>A	c.(262-264)gaG>gaA	p.E88E		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TAATGTTCTCCTCTGGAACAA	0.388000													21	49					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91739116	91739116	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:91739116C>T	ENST00000389857.6	-	30	6026	c.5940G>A	c.(5938-5940)aaG>aaA	p.K1980K	CCDC88C_ENST00000331194.7_Silent_p.K504K	NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1980					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				GACCTGGGCTCTTGGCCGGAA	0.711000													14	23					0	0	1	0	0
PBXIP1	57326	broad.mit.edu	37	1	154917523	154917523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154917523G>A	ENST00000368463.3	-	11	2244	c.2173C>T	c.(2173-2175)Cac>Tac	p.H725Y	PBXIP1_ENST00000539880.1_Missense_Mutation_p.H552Y|PBXIP1_ENST00000368465.1_Missense_Mutation_p.H696Y|PBXIP1_ENST00000542459.1_Missense_Mutation_p.H570Y	NM_020524.2	NP_065385.2	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein 1	725	His-rich.				cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			breast(1)|kidney(2)|large_intestine(6)|lung(13)|prostate(1)|urinary_tract(1)	24	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGGTGGTGGTGGCTATGGCTG	0.642000													20	47					0	0	1	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43678849	43678849	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:43678849C>T	ENST00000374466.3	+	8	1823	c.1488C>T	c.(1486-1488)ccC>ccT	p.P496P		NM_018590.3	NP_061060.3	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 2	496					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding	p.P496P(1)		endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						AGCTGACCCCCGAGCAGTACC	0.517000													22	212					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39227430	39227430	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:39227430C>T	ENST00000340369.3	-	2	3735	c.3507G>A	c.(3505-3507)agG>agA	p.R1169R	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1169							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGCAGTCTCCCTGTGCCTTG	0.637000													12	29					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77666836	77666836	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:77666836T>G	ENST00000461745.1	+	22	4366	c.3466T>G	c.(3466-3468)Tcc>Gcc	p.S1156A	ROBO2_ENST00000487694.3_Missense_Mutation_p.S1172A|ROBO2_ENST00000469233.1_3'UTR|ROBO2_ENST00000332191.8_Missense_Mutation_p.S1156A	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1156					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCTTACTCCATCCCCACGGGA	0.488000													13	90					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	36895318	36895318	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:36895318C>T	ENST00000310758.4	-	22	2669	c.2022G>A	c.(2020-2022)ggG>ggA	p.G674G	ELMO1_ENST00000448602.1_Silent_p.G674G|ELMO1_ENST00000396045.3_Silent_p.G194G|ELMO1_ENST00000341056.3_Silent_p.G376G|ELMO1_ENST00000396040.2_Silent_p.G194G|ELMO1_ENST00000442504.1_Silent_p.G674G	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	674	PH.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TCATGTCCTTCCCGAGTAGCG	0.517000													34	105					0	0	1	0	0
RNF133	168433	broad.mit.edu	37	7	122338165	122338165	+	Missense_Mutation	SNP	G	G	A	rs113296018	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:122338165G>A	ENST00000340112.2	-	1	1045	c.808C>T	c.(808-810)Cgt>Tgt	p.R270C	CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000412584.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	270						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						GTCAGAATACGAACTATGTCA	0.388000													41	104					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16000301	16000301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:16000301C>T	ENST00000221700.5	-	7	945	c.850G>A	c.(850-852)Gat>Aat	p.D284N	CYP4F2_ENST00000592328.1_Missense_Mutation_p.D284N|CYP4F2_ENST00000011989.7_Missense_Mutation_p.D135N	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	284					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AGGAAGTCATCAACACCCTGG	0.577000													35	127					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171765398	171765398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:171765398G>A	ENST00000311601.5	-	13	2881	c.2711C>T	c.(2710-2712)tCc>tTc	p.S904F	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	904	SH3 4.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAGATAGTTGGAAGGAATCCA	0.547000													30	95					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604792	58604792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:58604792C>T	ENST00000267485.7	-	2	1479	c.1285G>A	c.(1285-1287)Gat>Aat	p.D429N	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	429						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						AACAGGGCATCGTTTTCCTTG	0.413000													16	84					0	0	1	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113661535	113661535	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:113661535C>T	ENST00000393544.2	+	0	1583																											CTTCCCCTTTCCCCAGGGGTC	0.542000													10	118					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228525785	228525785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:228525785C>T	ENST00000570156.2	+	78	19886	c.19812C>T	c.(19810-19812)acC>acT	p.T6604T	OBSCN_ENST00000366707.4_Silent_p.T3281T|OBSCN_ENST00000422127.1_Silent_p.T5647T|OBSCN_ENST00000284548.11_Silent_p.T5647T|OBSCN_ENST00000366709.4_Silent_p.T2766T	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5647	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCAAGCCCACCAAGTCCAGCC	0.652000													6	15					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136587237	136587237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:136587237C>T	ENST00000264162.2	-	3	740	c.730G>A	c.(730-732)Gat>Aat	p.D244N		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	244	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGAGGAAATCGACCGTGTCC	0.408000													33	78					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14880842	14880842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:14880842G>A	ENST00000403951.2	-	2	466	c.47C>T	c.(46-48)tCc>tTc	p.S16F	DGKB_ENST00000444700.2_Missense_Mutation_p.S16F|DGKB_ENST00000402815.1_Missense_Mutation_p.S16F|DGKB_ENST00000406247.3_Missense_Mutation_p.S16F|DGKB_ENST00000399322.3_Missense_Mutation_p.S16F|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Missense_Mutation_p.S16F|DGKB_ENST00000407950.1_Missense_Mutation_p.S16F			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	16					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CTGAAGTTGGGAAAATTCCGA	0.368000													6	15					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115607039	115607039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:115607039G>A	ENST00000361384.2	-	3	3098	c.2181C>T	c.(2179-2181)gcC>gcT	p.A727A	DCLRE1A_ENST00000369305.1_Silent_p.A727A	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	727					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		TGAGAAAATAGGCTGTGCAAC	0.383000								Other identified genes with known or suspected DNA repair function					17	42					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41797462	41797462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:41797462C>T	ENST00000263800.6	-	15	1965	c.1869G>A	c.(1867-1869)ctG>ctA	p.L623L	LTK_ENST00000355166.5_Silent_p.L562L|LTK_ENST00000453182.2_Silent_p.L493L|LTK_ENST00000561619.1_Silent_p.L321L	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	623	Protein kinase.				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TGTCCTGGGCCAGTTGCAGCA	0.602000										TSP Lung(18;0.14)			18	39					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100235830	100235830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:100235830C>T	ENST00000355295.4	+	11	2296	c.2001C>T	c.(1999-2001)ctC>ctT	p.L667L	TDRD7_ENST00000422139.2_Silent_p.L593L|TDRD7_ENST00000540902.1_Silent_p.L16L	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	667					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				ATGGGACACTCTACTGCCAGG	0.438000													13	183					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673345	186673345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:186673345G>A	ENST00000343098.5	+	17	19579	c.19579G>A	c.(19579-19581)Gaa>Aaa	p.E6527K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E6438K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2									p.E1136K(2)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AACCAACAAAGAATTTTATTA	0.303000													6	30					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32750561	32750561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:32750561C>T	ENST00000421745.2	+	59	11920	c.11786C>T	c.(11785-11787)tCa>tTa	p.S3929L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	3929					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CGTGCTGTGTCAGCTACACCA	0.428000													28	57					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152536101	152536101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:152536101C>T	ENST00000367255.5	-	122	22887	c.22286G>A	c.(22285-22287)aGa>aAa	p.R7429K	SYNE1_ENST00000448038.1_Missense_Mutation_p.R7358K|SYNE1_ENST00000423061.1_Missense_Mutation_p.R7358K|SYNE1_ENST00000265368.4_Missense_Mutation_p.R7429K|SYNE1_ENST00000341594.5_Missense_Mutation_p.R7041K|SYNE1_ENST00000356820.4_Missense_Mutation_p.R1953K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7429					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTCTGCATTCTTTTGATTTC	0.413000										HNSCC(10;0.0054)			66	80					0	0	1	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47117396	47117396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:47117396C>T	ENST00000290341.3	+	7	1095	c.761C>T	c.(760-762)tCc>tTc	p.S254F	IGF2BP1_ENST00000431824.2_Intron	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	254	KH 1.|Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GAGGGCTGCTCCTCCGCTTGT	0.517000													56	67					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903153	5903153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:5903153G>A	ENST00000378961.4	+	4	567	c.363G>A	c.(361-363)gaG>gaA	p.E121E		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	121						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						CAGACACAGAGAAATGGGCAG	0.627000													21	22					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105407933	105407933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:105407933C>T	ENST00000333244.5	-	7	13974	c.13855G>A	c.(13855-13857)Gag>Aag	p.E4619K	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4619						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCTACATCCTCGTGGGCCAGG	0.547000													40	98					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369418	22369418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:22369418C>T	ENST00000332663.2	+	1	941	c.843C>T	c.(841-843)ttC>ttT	p.F281F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTTTAATATTCCCTTTACGTA	0.378000													6	77					0	0	1	0	0
GSTM1	2944	broad.mit.edu	37	1	110230845	110230845	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:110230845A>T	ENST00000309851.5	+	2	144	c.90A>T	c.(88-90)gaA>gaT	p.E30D	GSTM1_ENST00000349334.3_Missense_Mutation_p.E30D|GSTM1_ENST00000490021.2_Intron|GSTM1_ENST00000483399.2_Missense_Mutation_p.E30D|GSTM2_ENST00000460717.3_Intron|GSTM1_ENST00000369819.2_Missense_Mutation_p.E30D|GSTM1_ENST00000369823.2_Missense_Mutation_p.E30D|GSTM2_ENST00000369831.2_Intron	NM_000561.3	NP_000552.2	P09488	GSTM1_HUMAN	glutathione S-transferase mu 1	30	GST N-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity			endometrium(1)|lung(1)|ovary(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	GCTATGAGGAAAAGAAGTACA	0.607000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				72	56					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155222375	155222375	+	Missense_Mutation	SNP	C	C	T	rs149590749	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:155222375C>T	ENST00000460012.1	-	13	1940	c.1583G>A	c.(1582-1584)cGa>cAa	p.R528Q	PLCH1_ENST00000414191.1_Missense_Mutation_p.R528Q|PLCH1_ENST00000340059.7_Missense_Mutation_p.R546Q|PLCH1_ENST00000334686.6_Missense_Mutation_p.R528Q|PLCH1_ENST00000447496.2_Missense_Mutation_p.R546Q|PLCH1_ENST00000494598.1_Missense_Mutation_p.R546Q			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	546					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CATGAGGGATCGTCCATGTGA	0.313000													23	68					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38743715	38743715	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr6:38743715C>T	ENST00000359357.3	+	11	1553	c.1299C>T	c.(1297-1299)atC>atT	p.I433I	DNAH8_ENST00000441566.1_Silent_p.I433I|DNAH8_ENST00000449981.2_Silent_p.I650I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGACAAAAATCAATGGTTTAG	0.308000													46	117					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41045878	41045878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:41045878C>T	ENST00000399564.4	-	18	2256	c.1806G>A	c.(1804-1806)atG>atA	p.M602I	MROH2B_ENST00000506092.2_Missense_Mutation_p.M157I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TGTAACTGCCCATTTGCTGTT	0.443000													56	167					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20819666	20819666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:20819666G>A	ENST00000328879.4	-	4	747	c.591C>T	c.(589-591)taC>taT	p.Y197Y	KLHL22_ENST00000440659.2_Silent_p.Y54Y	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	197					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TGAGGAGGGAGTAGACCTTCT	0.557000													25	44					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13322932	13322932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:13322932G>A	ENST00000360228.5	-	43	6287	c.6288C>T	c.(6286-6288)ctC>ctT	p.L2096L	CACNA1A_ENST00000573710.2_Silent_p.L2097L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	2097					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCTCTGCAGGGAGGCGGGGCA	0.667000													9	39					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431416	140431416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140431416G>A	ENST00000306549.3	+	1	438	c.361G>A	c.(361-363)Gtc>Atc	p.V121I		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		121	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGCCGAGGTCAGGGTATT	0.517000													18	57					0	0	1	0	0
OR3A4P	390756	broad.mit.edu	37	17	3213625	3213625	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:3213625G>A	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							GGAACTCAGGGAATGATTCAG	0.517000													26	41					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65263330	65263330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:65263330C>T	ENST00000389722.3	-	10	1339	c.1286G>A	c.(1285-1287)cGg>cAg	p.R429Q	SPTB_ENST00000556626.1_Missense_Mutation_p.R429Q|SPTB_ENST00000542895.1_Missense_Mutation_p.R429Q|SPTB_ENST00000389721.5_Missense_Mutation_p.R429Q|SPTB_ENST00000389720.3_Missense_Mutation_p.R429Q	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	429					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGCGGCCTTCCGGTCAAAGCG	0.587000													21	56					0	0	1	0	0
PTPDC1	138639	broad.mit.edu	37	9	96827036	96827036	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:96827036C>T	ENST00000375360.3	+	2	355	c.15C>T	c.(13-15)gtC>gtT	p.V5V		NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	5							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						CTGCAGGAGTCTTGCCTCAGA	0.368000													20	47					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17444715	17444715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr22:17444715G>A	ENST00000400588.1	-	9	1588	c.1481C>T	c.(1480-1482)cCg>cTg	p.P494L		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	494										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TGCAGATGCCGGGTTCTGCTG	0.592000													15	44					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71163629	71163629	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:71163629G>A	ENST00000393567.2	-	9	1291	c.1141C>T	c.(1141-1143)Ctg>Ttg	p.L381L	HYDIN_ENST00000538248.1_Silent_p.L408L|HYDIN_ENST00000321489.5_Silent_p.L381L|HYDIN_ENST00000448089.2_Silent_p.L381L|HYDIN_ENST00000448691.1_Silent_p.L381L|HYDIN_ENST00000288168.10_Silent_p.L398L|HYDIN_ENST00000393550.2_Silent_p.L381L|HYDIN_ENST00000541601.1_Silent_p.L398L	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	381										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GTTCGGGACAGAACAGAAAGA	0.458000													13	26					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983578	97983578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97983578C>T	ENST00000383696.2	+	1	491	c.450C>T	c.(448-450)gtC>gtT	p.V150V	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TTTATCCAGTCATTATGACCA	0.363000													93	61					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134125730	134125730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:134125730C>T	ENST00000220616.4	+	44	7677	c.7637C>T	c.(7636-7638)tCt>tTt	p.S2546F	TG_ENST00000542445.1_Missense_Mutation_p.S916F|TG_ENST00000519543.1_Missense_Mutation_p.S679F|TG_ENST00000377869.1_Missense_Mutation_p.S2489F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2546					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTGCAGAATTCTCTGGGTGGC	0.512000													27	70					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23079830	23079830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:23079830G>A	ENST00000219689.7	-	16	3595	c.3596C>T	c.(3595-3597)tCc>tTc	p.S1199F	USP31_ENST00000567975.1_Missense_Mutation_p.S492F	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1199	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GGCCATGGAGGAGCTCCGCAC	0.642000													38	89					0	0	1	0	0
SCLT1	132320	broad.mit.edu	37	4	129873956	129873956	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:129873956G>A	ENST00000281142.5	-	14	1689	c.1186C>T	c.(1186-1188)Cga>Tga	p.R396*	SCLT1_ENST00000502495.1_5'UTR|SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000503215.1_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	396						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						TCTGTTAATCGAGAAATTTGT	0.259000													37	104					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102496039	102496039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:102496039G>A	ENST00000260228.2	-	1	24	c.12C>T	c.(10-12)ctC>ctT	p.L4L	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	4					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CAGATGCAGGGAGCACCTTCA	0.532000													15	44					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6243299	6243299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6243299G>A	ENST00000400104.3	-	7	654	c.454C>T	c.(454-456)Cct>Tct	p.P152S	L3MBTL4_ENST00000400105.2_Missense_Mutation_p.P152S|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.P152S|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.P152S			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	152					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TTACCCTTAGGGATGTGCAGT	0.368000													25	89					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18391011	18391011	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:18391011C>T	ENST00000338745.6	-	11	3677	c.1943G>A	c.(1942-1944)cGa>cAa	p.R648Q	SATB1_ENST00000417717.2_Missense_Mutation_p.R680Q|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000454909.2_Missense_Mutation_p.R648Q	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	648					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						AATTTTTGTTCGTGGCCGGGT	0.587000													35	87					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40368833	40368833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:40368833C>T	ENST00000221347.6	-	28	12522	c.12515G>A	c.(12514-12516)gGg>gAg	p.G4172E		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4172	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGAAATCCGCCCGTCGGCCAC	0.617000													37	223					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995778	140995778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrX:140995778C>T	ENST00000285879.4	+	4	2874	c.2588C>T	c.(2587-2589)tCa>tTa	p.S863L	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	863							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCCACTTCATTGAGCCCA	0.517000										HNSCC(15;0.026)			109	66					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12315809	12315809	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:12315809C>T	ENST00000256186.2	+	3	1122	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	277					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		CCAATGCCATCCGAAGGTCTC	0.607000													20	56					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168073894	168073894	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:168073894G>A	ENST00000367838.1	-	4	508	c.195C>T	c.(193-195)ttC>ttT	p.F65F	GPR161_ENST00000539777.1_Intron|GPR161_ENST00000537209.1_Silent_p.F85F|GPR161_ENST00000546300.1_Intron|GPR161_ENST00000361697.2_Silent_p.F65F|GPR161_ENST00000367836.1_Intron|GPR161_ENST00000271357.5_Silent_p.F65F|GPR161_ENST00000367835.1_Silent_p.F65F	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	65					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.F65F(1)		breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					GGCTGAAGACGAACTTGTTGC	0.517000													47	84					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516156	140516156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140516156G>A	ENST00000231134.5	+	1	1357	c.1140G>A	c.(1138-1140)atG>atA	p.M380I		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		380	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGGTAGGATGATTTGCTCCA	0.488000													32	78					0	0	1	0	0
FYCO1	79443	broad.mit.edu	37	3	45972760	45972760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:45972760G>A	ENST00000296137.2	-	16	4259	c.4054C>T	c.(4054-4056)Ctc>Ttc	p.L1352F	FYCO1_ENST00000535325.1_Missense_Mutation_p.L1372F|FYCO1_ENST00000438446.1_Missense_Mutation_p.L23F	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	1352	GOLD.				transport	integral to membrane	metal ion binding|protein binding	p.L1352F(1)		NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		TCCACTGTGAGGGGTACTTTG	0.547000													10	32					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57043060	57043060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr17:57043060G>A	ENST00000308249.2	+	3	718	c.589G>A	c.(589-591)Gag>Aag	p.E197K		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	206					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			CACAGAGATTGAGACAGTGAA	0.463000													112	300					0	0	1	0	0
MIA2	117153	broad.mit.edu	37	14	39721990	39721990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:39721990G>A	ENST00000280082.3	+	5	1805	c.1606G>A	c.(1606-1608)Gaa>Aaa	p.E536K	RP11-407N17.3_ENST00000553728.1_Intron	NM_054024.3	NP_473365.3	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	145						extracellular region				NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	31	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		GAGAATTCACGAAGAAGTATA	0.378000													27	89					0	0	1	0	0
ZNF597	146434	broad.mit.edu	37	16	3486894	3486894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:3486894C>T	ENST00000301744.4	-	4	1040	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K	LA16c-306E5.2_ENST00000575785.1_RNA	NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	269					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						TTAGTAGATTCGTAGGTGTTT	0.433000													30	138					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837305	82837305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:82837305C>T	ENST00000265077.3	+	8	9048	c.8483C>T	c.(8482-8484)cCc>cTc	p.P2828L	VCAN_ENST00000512590.2_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.P1841L|VCAN_ENST00000342785.4_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2828	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCATCATCTCCCCTCACTATC	0.498000													21	127					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62672641	62672641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:62672641G>A	ENST00000498273.1	+	3	636	c.341G>A	c.(340-342)gGg>gAg	p.G114E		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	114										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						caaaaaacagggatggtaggg	0.333000													34	116					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947667	237947667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:237947667G>A	ENST00000366574.2	+	90	12972	c.12655G>A	c.(12655-12657)Gaa>Aaa	p.E4219K	RYR2_ENST00000542537.1_Missense_Mutation_p.E4203K|RYR2_ENST00000360064.6_Missense_Mutation_p.E4225K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4219					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCGAATAAGGAAGAAAGCGA	0.537000													13	55					0	0	1	0	0
PANX1	24145	broad.mit.edu	37	11	93912938	93912938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:93912938C>T	ENST00000227638.3	+	4	1101	c.716C>T	c.(715-717)tCa>tTa	p.S239L	PANX1_ENST00000436171.2_Missense_Mutation_p.S239L	NM_015368.3	NP_056183.2	Q96RD7	PANX1_HUMAN	pannexin 1	239					positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding			endometrium(2)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGCCTCTCCTCACTCTCAGAC	0.468000													25	83					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60911420	60911420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr20:60911420G>A	ENST00000252999.3	-	18	2365	c.2299C>T	c.(2299-2301)Ccc>Tcc	p.P767S		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	767	Laminin EGF-like 9.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGTTGCTGGGGCTCAGTCCC	0.622000													23	62					0	0	1	0	0
TPPP2	122664	broad.mit.edu	37	14	21499223	21499223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:21499223G>A	ENST00000321760.6	+	3	374	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	TPPP2_ENST00000530140.2_Missense_Mutation_p.E76K|TPPP2_ENST00000460647.2_Missense_Mutation_p.E76K|NDRG2_ENST00000403829.3_Intron	NM_173846.4	NP_776245.2	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family member 2	76						cytoplasm				endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GGCAGTGAAGGAACTGGGCCA	0.502000													29	63					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154625688	154625688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:154625688C>T	ENST00000260010.6	+	1	3037	c.1629C>T	c.(1627-1629)tcC>tcT	p.S543S		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	543					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				AATTCCTCTCCTTCACTCAGG	0.473000													22	37					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104044065	104044065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:104044065G>A	ENST00000265148.3	-	43	7195	c.7106C>T	c.(7105-7107)cCt>cTt	p.P2369L	CENPE_ENST00000380026.3_Missense_Mutation_p.P2248L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2369	Kinetochore-binding domain.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TGTAACATGAGGATTCTTATT	0.343000													33	130					0	0	1	0	0
RIT2	6014	broad.mit.edu	37	18	40503539	40503539	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:40503539G>A	ENST00000589109.1	-	4	595	c.424C>T	c.(424-426)Cag>Tag	p.Q142*	RIT2_ENST00000326695.5_Nonsense_Mutation_p.Q142*|RIT2_ENST00000282028.4_Nonsense_Mutation_p.Q142*|RIT2_ENST00000590910.1_Silent_p.A162A	NM_001272077.1	NP_001259006.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	142					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCACTCACCTGGCGGAACTGT	0.458000													42	206					0	0	1	0	0
GPC1	2817	broad.mit.edu	37	2	241405670	241405670	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:241405670T>A	ENST00000264039.2	+	9	1888	c.1640T>A	c.(1639-1641)tTc>tAc	p.F547Y	GPC1_ENST00000466624.1_3'UTR	NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	547					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		CTCCTCCTCTTCCTGGCCCTT	0.632000													5	59					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052906	44052906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:44052906C>T	ENST00000306006.6	-	2	1274	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K	ZNF239_ENST00000374446.2_Missense_Mutation_p.E208K|ZNF239_ENST00000535642.1_Missense_Mutation_p.E208K|ZNF239_ENST00000426961.1_Missense_Mutation_p.E208K	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGACTACATTCGTATTGTTTC	0.423000													27	73					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2041160	2041160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:2041160G>A	ENST00000250896.3	-	12	1233	c.989C>T	c.(988-990)cCc>cTc	p.P330L	MKNK2_ENST00000588014.1_Missense_Mutation_p.P74L|MKNK2_ENST00000591588.1_Missense_Mutation_p.P74L|MKNK2_ENST00000591601.1_Missense_Mutation_p.P330L|MKNK2_ENST00000591142.1_Missense_Mutation_p.P74L|MKNK2_ENST00000541165.1_Missense_Mutation_p.P199L|MKNK2_ENST00000309340.7_Missense_Mutation_p.P330L	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	330	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCTTGTCGGGGAACTCGTA	0.592000													37	84					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27516538	27516538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr8:27516538G>A	ENST00000301904.3	+	5	871	c.851G>A	c.(850-852)gGg>gAg	p.G284E	SCARA3_ENST00000337221.4_Missense_Mutation_p.G284E	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	284					response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		GCCACCCTGGGGGCCTCCTCA	0.597000													14	32					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14889987	14889987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chrY:14889987C>T	ENST00000338981.3	+	20	3619	c.2674C>T	c.(2674-2676)Cgg>Tgg	p.R892W	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	892					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TCTTATAGTTCGGTTTCCAAA	0.343000													15	18					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683229	140683229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140683229G>A	ENST00000239451.4	-	1	383	c.204C>T	c.(202-204)ggC>ggT	p.G68G		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	68					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TAAGTGCCGGGCCGGTGCCCT	0.577000													29	90					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475911	140475911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:140475911G>A	ENST00000194155.4	+	1	1685	c.1537G>A	c.(1537-1539)Ggc>Agc	p.G513S		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		513	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCGGACAACGGCCACCTGTT	0.701000													58	171					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743738	81743738	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:81743738C>T	ENST00000555447.1	-	6	2329	c.1917G>A	c.(1915-1917)tgG>tgA	p.W639*	STON2_ENST00000267540.2_Nonsense_Mutation_p.W639*	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	639	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GGAGCTTGATCCACTTTGTGG	0.532000													16	43					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31876800	31876800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:31876800G>A	ENST00000396184.3	-	12	1401	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	PDE1C_ENST00000396191.1_Silent_p.F399F|PDE1C_ENST00000321453.7_Silent_p.F399F|PDE1C_ENST00000396193.1_Silent_p.F459F|PDE1C_ENST00000396182.2_Silent_p.F399F	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	399	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GTACCTGTCTGAAGAACTCCT	0.428000													32	68					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72307659	72307659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:72307659C>T	ENST00000334456.5	-	6	712	c.467G>A	c.(466-468)gGg>gAg	p.G156E	PDE2A_ENST00000540345.1_Missense_Mutation_p.G147E|PDE2A_ENST00000418754.2_Intron|PDE2A_ENST00000444035.2_Missense_Mutation_p.G147E|PDE2A_ENST00000544570.1_Missense_Mutation_p.G149E|PDE2A_ENST00000376450.3_Intron	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	156					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	TGCCACGGCCCCAGCCTCCTT	0.647000													9	25					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6985585	6985585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr18:6985585C>T	ENST00000389658.3	-	38	5530	c.5437G>A	c.(5437-5439)Gga>Aga	p.G1813R		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1813	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATCCTCTTCCTTGGACAATG	0.418000													23	50					0	0	1	0	0
RLN1	6013	broad.mit.edu	37	9	5335409	5335409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:5335409G>A	ENST00000223862.1	-	2	526	c.400C>T	c.(400-402)Cgc>Tgc	p.R134C	RLN1_ENST00000487557.2_5'UTR|RLN1_ENST00000223858.4_3'UTR	NM_006911.2	NP_008842.1	P04808	REL1_HUMAN	relaxin 1	134					female pregnancy|signal transduction	extracellular region	hormone activity			large_intestine(1)|lung(4)	5	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.02)|Lung(218;0.0984)		TGCCTATTGCGAATAAGTTTC	0.408000													41	88					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151747249	151747249	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:151747249G>A	ENST00000368822.1	-	12	2203	c.1570C>T	c.(1570-1572)Ctc>Ttc	p.L524F	TDRKH_ENST00000440583.2_Missense_Mutation_p.L300F|TDRKH_ENST00000458431.2_Missense_Mutation_p.L524F|TDRKH_ENST00000368823.1_Missense_Mutation_p.L520F|TDRKH_ENST00000368827.6_Missense_Mutation_p.L524F|TDRKH_ENST00000368825.3_Missense_Mutation_p.L479F|TDRKH_ENST00000368824.3_Missense_Mutation_p.L524F			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	524							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTCTCAGTGAGCAACGTGCTG	0.468000													55	142					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94935757	94935757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:94935757C>T	ENST00000337425.5	-	2	549	c.475G>A	c.(475-477)Gag>Aag	p.E159K	SERPINA9_ENST00000448305.2_Missense_Mutation_p.E61K|SERPINA9_ENST00000424550.2_Missense_Mutation_p.E10K|SERPINA9_ENST00000546329.1_Missense_Mutation_p.E123K|SERPINA9_ENST00000380365.3_Missense_Mutation_p.E141K|SERPINA9_ENST00000298845.7_Intron	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	141					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		AGCTGCAGCTCCTTCTTGACG	0.527000													15	139					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906248	164906248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:164906248G>A	ENST00000475390.1	-	2	2814	c.2371C>T	c.(2371-2373)Ctc>Ttc	p.L791F	SLITRK3_ENST00000241274.3_Missense_Mutation_p.L791F			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	791						integral to membrane		p.L791I(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CTTCCTAGGAGAGCCTCACCC	0.572000										HNSCC(40;0.11)			39	78					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33467054	33467054	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr5:33467054C>T	ENST00000265112.3	+	18	2298	c.1987C>T	c.(1987-1989)Cga>Tga	p.R663*	TARS_ENST00000541634.1_Nonsense_Mutation_p.R559*|TARS_ENST00000455217.2_Nonsense_Mutation_p.R696*|TARS_ENST00000414361.2_Nonsense_Mutation_p.R542*|TARS_ENST00000502553.1_Nonsense_Mutation_p.R663*	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	663					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity	p.R663*(1)		NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	TAAAAAGATTCGAAATGCACA	0.373000													28	58					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102849529	102849529	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:102849529G>A	ENST00000264257.2	+	10	1368	c.1242G>A	c.(1240-1242)gaG>gaA	p.E414E	IL1RL2_ENST00000441515.2_Silent_p.E296E|IL1RL2_ENST00000481806.1_3'UTR|IL1RL2_ENST00000539491.1_Silent_p.E414E	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	414	TIR.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						AGGTGTTGGAGAGACAATGTG	0.448000													39	73					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124896607	124896607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:124896607G>A	ENST00000423114.2	-	5	688	c.689C>T	c.(688-690)tCt>tTt	p.S230F	SLC12A8_ENST00000314584.7_5'UTR|SLC12A8_ENST00000393469.4_Missense_Mutation_p.S201F|SLC12A8_ENST00000469902.1_Missense_Mutation_p.S201F			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	201					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						GTGGGTGAAAGAACCCACCAC	0.522000													16	24					0	0	1	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31487875	31487875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:31487875G>A	ENST00000394863.3	+	9	1092	c.962G>A	c.(961-963)gGa>gAa	p.G321E	TGFB1I1_ENST00000361773.3_Missense_Mutation_p.G304E|TGFB1I1_ENST00000394858.2_Missense_Mutation_p.G304E|TGFB1I1_ENST00000567607.1_Missense_Mutation_p.G304E	NM_001042454.2	NP_001035919.1	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced transcript 1	321	LIM zinc-binding 2.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding			lung(8)|upper_aerodigestive_tract(1)	9						GAGCCCTTCGGAGATGAGGGT	0.637000													5	11					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43869432	43869432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:43869432C>T	ENST00000562955.1	+	3	314	c.314C>T	c.(313-315)tCt>tTt	p.S105F	SZT2_ENST00000310739.4_Missense_Mutation_p.S105F|SZT2_ENST00000372450.4_Missense_Mutation_p.S103F	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	105						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CTTAGCCCATCTACTGGCATT	0.547000													47	125					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20990669	20990669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr16:20990669C>T	ENST00000261383.3	-	50	8058	c.8059G>A	c.(8059-8061)Gac>Aac	p.D2687N	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2687	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCTGCAAAGTCGAGTTTCTGC	0.512000													13	44					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127944882	127944882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:127944882C>T	ENST00000335247.7	-	8	1214	c.1084G>A	c.(1084-1086)Ggg>Agg	p.G362R	CYP27C1_ENST00000409327.1_Missense_Mutation_p.G362R	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	362						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		TGGATGGGCCCCCCTGGCGTC	0.473000													33	60					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183652084	183652084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr4:183652084C>T	ENST00000511685.1	+	16	2882	c.2759C>T	c.(2758-2760)tCc>tTc	p.S920F	TENM3_ENST00000406950.2_Missense_Mutation_p.S920F|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		TTTGAACGATCCCCATTCCTC	0.418000													21	23					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157414071	157414071	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:157414071G>A	ENST00000389413.3	-	14	2343	c.2240C>T	c.(2239-2241)tCc>tTc	p.S747F	PTPRN2_ENST00000409483.1_Missense_Mutation_p.S738F|PTPRN2_ENST00000404321.2_Missense_Mutation_p.S799F|PTPRN2_ENST00000389416.4_Missense_Mutation_p.S759F|PTPRN2_ENST00000389418.4_Missense_Mutation_p.S776F	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	776	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CACGGCCAGGGAGCGGTTCTT	0.662000													75	207					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21882208	21882208	+	Missense_Mutation	SNP	C	C	T	rs72657399		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:21882208C>T	ENST00000328843.6	+	67	10790	c.10759C>T	c.(10759-10761)Cgc>Tgc	p.R3587C	DNAH11_ENST00000409508.3_Missense_Mutation_p.R3580C			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3587	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CAAGAACTTTCGCCTTATCCT	0.393000									Kartagener syndrome				12	36					0	0	1	0	0
LOC101929735	101929735	broad.mit.edu	37	14	22935530	22935530	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22935530G>A	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA																							TTTCTTCTCAGCCTCTGCCTC	0.458000													12	24					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103814264	103814264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:103814264C>T	ENST00000302251.5	-	5	1121	c.670G>A	c.(670-672)Gag>Aag	p.E224K	PDGFD_ENST00000393158.2_Missense_Mutation_p.E230K	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	230					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TGCCATGACTCTGGATTGAAG	0.453000													3	28					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154544019	154544019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:154544019C>T	ENST00000368476.3	+	5	984	c.720C>T	c.(718-720)aaC>aaT	p.N240N		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	240					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	ACACCATCAACCTCATCATCC	0.572000													51	125					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	82147756	82147756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:82147756G>A	ENST00000550584.2	-	2	540	c.245C>T	c.(244-246)cCa>cTa	p.P82L	PPFIA2_ENST00000549396.1_Missense_Mutation_p.P82L|PPFIA2_ENST00000548586.1_Missense_Mutation_p.P82L|PPFIA2_ENST00000552948.1_Missense_Mutation_p.P82L|PPFIA2_ENST00000549325.1_Missense_Mutation_p.P82L|PPFIA2_ENST00000333447.7_Missense_Mutation_p.P82L	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	340										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GCATACCTGTGGCAGGGCTGA	0.443000													9	19					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108818274	108818274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:108818274C>T	ENST00000232603.5	-	6	436	c.354G>A	c.(352-354)acG>acA	p.T118T	MORC1_ENST00000483760.1_Silent_p.T118T	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	118					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding	p.T118T(1)		breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						CTTCCTTCTTCGTAAAAAGAA	0.343000													22	38					0	0	1	0	0
SRCRB4D	136853	broad.mit.edu	37	7	76029657	76029657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:76029657C>T	ENST00000275560.3	-	4	768	c.421G>A	c.(421-423)Ggc>Agc	p.G141S	ZP3_ENST00000336517.4_Intron	NM_080744.1	NP_542782.1	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain containing, group B (4 domains)	141	SRCR 1.					extracellular region|membrane	scavenger receptor activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(9)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21						ACGCCCCAGCCGCGGCTGCCG	0.662000													7	43					0	0	1	0	0
TRAV8-6	28680	broad.mit.edu	37	14	22447294	22447294	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22447294C>T	ENST00000390443.3	+	0	495																											AGTCAAACTTCCTTCCACTTG	0.483000											OREG0022573	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	81					0	0	1	0	0
FAM180A	389558	broad.mit.edu	37	7	135419000	135419000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr7:135419000G>A	ENST00000338588.3	-	3	510	c.245C>T	c.(244-246)tCc>tTc	p.S82F	FAM180A_ENST00000415751.1_Missense_Mutation_p.S82F	NM_205855.3	NP_995327.1	Q6UWF9	F180A_HUMAN	family with sequence similarity 180, member A	82						extracellular region				endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)	14						CTTCCGCAAGGAGGCCAGCTC	0.577000													44	97					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32657319	32657319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:32657319C>T	ENST00000335185.5	-	14	1151	c.1108G>A	c.(1108-1110)Gaa>Aaa	p.E370K	CCDC73_ENST00000534415.1_5'UTR	NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	370										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					ATATGAGTTTCTTTAAGGGAT	0.254000													11	27					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48733332	48733332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48733332G>A	ENST00000285238.8	+	2	265	c.185G>A	c.(184-186)gGc>gAc	p.G62D	ABCC3_ENST00000427699.1_Missense_Mutation_p.G62D	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	62					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CATTGTCGTGGCTACATCATC	0.582000													15	48					0	0	1	0	0
MYEOV	26579	broad.mit.edu	37	11	69063588	69063588	+	Missense_Mutation	SNP	C	C	T	rs138762742	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:69063588C>T	ENST00000535407.1	+	2	1140	c.497C>T	c.(496-498)tCg>tTg	p.S166L	MYEOV_ENST00000441339.2_Missense_Mutation_p.S224L|MYEOV_ENST00000308946.3_Missense_Mutation_p.S224L			Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	224										endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|urinary_tract(1)	24	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		CTGGCAGAATCGAGCTGCCCT	0.637000													31	47					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755960	140755960	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140755960C>T	ENST00000517434.1	+	1	2310	c.2310C>T	c.(2308-2310)ttC>ttT	p.F770F	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTGATTTTCCCCCAGCCCA	0.517000													32	120					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48703660	48703660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48703660C>T	ENST00000352832.5	+	34	6673	c.6301C>T	c.(6301-6303)Ctc>Ttc	p.L2101F	CACNA1G_ENST00000512389.1_Missense_Mutation_p.L2124F|CACNA1G_ENST00000507336.1_Missense_Mutation_p.L2217F|CACNA1G_ENST00000507609.1_Missense_Mutation_p.L2128F|CACNA1G_ENST00000354983.4_Missense_Mutation_p.L2194F|CACNA1G_ENST00000503485.1_Missense_Mutation_p.L2101F|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000510115.1_Missense_Mutation_p.L2149F|CACNA1G_ENST00000510366.1_Missense_Mutation_p.L2083F|CACNA1G_ENST00000502264.1_Missense_Mutation_p.L2157F|CACNA1G_ENST00000429973.2_Missense_Mutation_p.L2117F|CACNA1G_ENST00000360761.4_Missense_Mutation_p.L2112F|CACNA1G_ENST00000515765.1_Missense_Mutation_p.L2172F|CACNA1G_ENST00000515411.1_Missense_Mutation_p.L2165F|CACNA1G_ENST00000442258.2_Missense_Mutation_p.L2094F|CACNA1G_ENST00000515165.1_Missense_Mutation_p.L2135F|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000359106.5_Missense_Mutation_p.L2228F|CACNA1G_ENST00000514717.1_Missense_Mutation_p.L2078F|CACNA1G_ENST00000514181.1_Missense_Mutation_p.L2110F|CACNA1G_ENST00000514079.1_Missense_Mutation_p.L2142F|CACNA1G_ENST00000513964.1_Missense_Mutation_p.L2090F|CACNA1G_ENST00000507510.2_Missense_Mutation_p.L2183F|CACNA1G_ENST00000513689.2_Missense_Mutation_p.L2138F	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	2228					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TTCAGGAGACCTCCTGCCCCC	0.662000											OREG0024569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	50					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61562318	61562318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61562318G>A	ENST00000577647.1	+	1	135	c.90G>A	c.(88-90)gaG>gaA	p.E30E	ACE_ENST00000413513.3_Silent_p.E30E|ACE_ENST00000290866.4_Intron|ACE_ENST00000428043.1_Intron|ACE_ENST00000490216.2_Silent_p.E30E|ACE_ENST00000290863.6_Silent_p.E30E|ACE_ENST00000421982.2_5'UTR			P12821	ACE_HUMAN	angiotensin I converting enzyme	0	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CCAGCCAGGAGGCATCCCAAC	0.652000													6	12					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112720813	112720813	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:112720813G>A	ENST00000408903.3	-	2	682	c.267C>T	c.(265-267)tcC>tcT	p.S89S	CTD-2201G3.1_ENST00000416046.2_RNA	NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	0					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		AATCCTGAAAGGAAATCTTCC	0.448000													45	104					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247737658	247737658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247737658G>A	ENST00000366491.2	+	7	819	c.322G>A	c.(322-324)Gat>Aat	p.D108N	RP11-978I15.10_ENST00000446347.1_RNA|GCSAML_ENST00000527084.1_Missense_Mutation_p.D96N|GCSAML_ENST00000463359.1_Missense_Mutation_p.D96N|RP11-978I15.10_ENST00000435333.1_RNA|GCSAML_ENST00000366489.1_Missense_Mutation_p.D108N|GCSAML_ENST00000536561.1_Missense_Mutation_p.D108N|GCSAML_ENST00000366488.4_Missense_Mutation_p.D128N|GCSAML_ENST00000527541.1_Missense_Mutation_p.D96N					germinal center-associated, signaling and motility-like																		CCATGAGCATGATTATGAAGT	0.438000													32	72					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193201771	193201771	+	Silent	SNP	G	G	A	rs111773905	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:193201771G>A	ENST00000342695.4	-	8	1084	c.762C>T	c.(760-762)ctC>ctT	p.L254L	ATP13A4_ENST00000392443.3_Silent_p.L254L|ATP13A4_ENST00000295548.3_Silent_p.L254L	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	254					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GTGACTCGACGAGATGGTGGA	0.348000													48	63					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97852431	97852431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:97852431G>A	ENST00000447648.2	-	21	3098	c.2799C>T	c.(2797-2799)gcC>gcT	p.A933A	TECPR1_ENST00000479975.1_5'UTR|TECPR1_ENST00000379795.3_Silent_p.A935A			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	933						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CGTCCCTGAGGGCGATGGGGG	0.667000													3	8					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6925289	6925289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6925289C>T	ENST00000011653.4	+	6	933	c.675C>T	c.(673-675)ctC>ctT	p.L225L	CD4_ENST00000538827.1_3'UTR|CD4_ENST00000541982.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	225	Ig-like C2-type 2.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				CCTTCCCACTCGCCTTTACAG	0.562000													39	71					0	0	1	0	0
SRRM3	222183	broad.mit.edu	37	7	75894696	75894696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:75894696C>T	ENST00000388802.4	+	10	949	c.740C>T	c.(739-741)tCc>tTc	p.S247F	SRRM3_ENST00000326382.8_Missense_Mutation_p.S247F					serine/arginine repetitive matrix 3									p.S247Y(1)		NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)	8						CACACAGAGTCCCCAGGCCGG	0.642000													22	45					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21225528	21225528	+	Missense_Mutation	SNP	C	C	T	rs61743313	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21225528C>T	ENST00000233242.1	-	29	12893	c.12766G>A	c.(12766-12768)Gag>Aag	p.E4256K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4256					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCCTTAACTCGAAAGGAAGT	0.378000													38	106					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71740883	71740883	+	Missense_Mutation	SNP	G	G	A	rs146975565		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:71740883G>A	ENST00000269500.5	-	10	1453	c.1118C>T	c.(1117-1119)tCg>tTg	p.S373L	FBXO15_ENST00000580806.1_5'UTR|FBXO15_ENST00000419743.2_Missense_Mutation_p.S449L	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	373										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		TGTGGCAGGCGATCTCAGGCA	0.502000													55	197					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40815211	40815211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40815211G>A	ENST00000396617.3	-	12	1821	c.1231C>T	c.(1231-1233)Cca>Tca	p.P411S	MKL1_ENST00000402042.1_Missense_Mutation_p.P361S|MKL1_ENST00000407029.1_Missense_Mutation_p.P411S|MKL1_ENST00000355630.3_Missense_Mutation_p.P411S			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	411					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						CGGGCCGCTGGGAAGGCTACC	0.677000			T	RBM15	acute megakaryocytic leukemia								3	9					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62995971	62995971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62995971C>T	ENST00000306494.6	-	2	467	c.468G>A	c.(466-468)atG>atA	p.M156I	SLC22A25_ENST00000403374.2_5'UTR|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	156					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CTCCCACCATCATTCCAGCCA	0.408000													17	84					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77799640	77799640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:77799640G>A	ENST00000407578.2	-	19	3053	c.2787C>T	c.(2785-2787)taC>taT	p.Y929Y	MYCBP2_ENST00000357337.6_Silent_p.Y891Y|MYCBP2_ENST00000544440.2_Silent_p.Y891Y|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	891					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGCCTGGAGGGTATGTTGTGA	0.443000													38	84					0	0	1	0	0
MIR371B	100616185	broad.mit.edu	37	19	54290995	54290995	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54290995C>T	ENST00000595160.1	-	0	301				MIR371A_ENST00000362161.1_RNA	NR_029864.1|NR_029865.1|NR_039909.1																						TTGAGTGTTACCGCTTGAGAA	0.572000													10	27					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7173259	7173259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7173259C>T	ENST00000406697.1	+	10	1484	c.856C>T	c.(856-858)Cgc>Tgc	p.R286C	C1S_ENST00000328916.3_Missense_Mutation_p.R286C|C1S_ENST00000402681.3_Missense_Mutation_p.R119C|C1S_ENST00000360817.5_Missense_Mutation_p.R286C			P09871	C1S_HUMAN	complement component 1, s subcomponent	286	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	CTGGAAACTTCGCTATCATGG	0.433000													22	65					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57666645	57666645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57666645C>T	ENST00000554048.2	-	5	533	c.534G>A	c.(532-534)gaG>gaA	p.E178E		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	178						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CTTGCAGTCCCTCAGGAATCT	0.498000													5	81					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561313	9561313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9561313C>T	ENST00000378429.3	-	5	1015	c.469G>A	c.(469-471)Gat>Aat	p.D157N	PAK7_ENST00000378423.1_Missense_Mutation_p.D157N|PAK7_ENST00000353224.5_Missense_Mutation_p.D157N	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	157	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TAATACGGATCCAGATCATCT	0.483000													60	166					0	0	1	0	0
NR6A1	2649	broad.mit.edu	37	9	127302413	127302413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127302413C>T	ENST00000487099.2	-	5	652	c.495G>A	c.(493-495)gaG>gaA	p.E165E	NR6A1_ENST00000416460.2_Silent_p.E161E|NR6A1_ENST00000373584.3_Silent_p.E161E|NR6A1_ENST00000344523.4_Silent_p.E165E	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	165					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						AGTGATTGGCCTCTTCCTCAA	0.512000													27	140					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113285537	113285537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113285537G>A	ENST00000389385.4	+	5	617	c.120G>A	c.(118-120)caG>caA	p.Q40Q	RPH3A_ENST00000551052.1_Silent_p.Q36Q|RPH3A_ENST00000548866.1_Intron|RPH3A_ENST00000420983.2_Silent_p.Q40Q|RPH3A_ENST00000447659.2_Intron|RPH3A_ENST00000543106.2_Silent_p.Q40Q|RPH3A_ENST00000415485.3_Silent_p.Q40Q	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	40					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		CCGGTGGTCAGCCTGACAGGC	0.532000													39	78					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30381660	30381660	+	Missense_Mutation	SNP	G	G	A	rs61754553	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30381660G>A	ENST00000340513.4	+	15	2155	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K	TPX2_ENST00000300403.6_Missense_Mutation_p.E507K			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	507					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GGAAGAGGACGAACCGGTAGT	0.433000													87	214					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31918627	31918627	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31918627G>A	ENST00000396184.3	-	5	611	c.407C>T	c.(406-408)gCt>gTt	p.A136V	PDE1C_ENST00000396182.2_Missense_Mutation_p.A136V|PDE1C_ENST00000396191.1_Missense_Mutation_p.A136V|PDE1C_ENST00000321453.7_Missense_Mutation_p.A136V|PDE1C_ENST00000396193.1_Missense_Mutation_p.A196V	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	136					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			AAATATCCCAGCCTGCACTGC	0.507000													25	134					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774626	121774626	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121774626G>A	ENST00000264808.3	-	3	487	c.247C>T	c.(247-249)Cgc>Tgc	p.R83C	PRDM5_ENST00000428209.2_Missense_Mutation_p.R83C|PRDM5_ENST00000515109.1_Missense_Mutation_p.R83C|PRDM5_ENST00000394435.2_Missense_Mutation_p.R83C	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	83	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGAACGAAGCGAAGCCAGTTG	0.468000													36	426					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49700992	49700992	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49700992G>A	ENST00000433368.2	-	6	575	c.506C>T	c.(505-507)tCt>tTt	p.S169F	CRISP3_ENST00000423399.2_Missense_Mutation_p.S56F|CRISP3_ENST00000263045.4_Missense_Mutation_p.S159F|CRISP3_ENST00000393666.1_Missense_Mutation_p.S146F|CRISP3_ENST00000371159.4_Missense_Mutation_p.S177F	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	146					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GAGGTATGAAGAGTACCAAAC	0.328000													61	129					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77677851	77677851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77677851G>A	ENST00000296043.6	+	8	5912	c.4959G>A	c.(4957-4959)aaG>aaA	p.K1653K		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1653					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GTTTAGAAAAGAAAGTCAGTC	0.493000													22	78					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	122018775	122018775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122018775G>A	ENST00000377071.4	-	1	114	c.42C>T	c.(40-42)ccC>ccT	p.P14P	KDM2B_ENST00000536437.1_5'UTR|KDM2B_ENST00000538046.2_Silent_p.P14P|RP13-941N14.1_ENST00000541574.1_lincRNA	NM_032590.4	NP_115979.3	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	14					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						TTTTTCGTGGGGGGTGATCCT	0.483000													38	135					0	0	1	0	0
NR0B2	8431	broad.mit.edu	37	1	27238395	27238395	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27238395G>A	ENST00000254227.3	-	2	740	c.715C>T	c.(715-717)Cct>Tct	p.P239S		NM_021969.2	NP_068804.1	Q15466	NR0B2_HUMAN	nuclear receptor subfamily 0, group B, member 2	239					cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity			NS(1)|large_intestine(1)|lung(3)	5		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		CCAATGATAGGGCGAAAGAAG	0.612000													30	116					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608361	4608361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4608361G>A	ENST00000312614.4	+	1	341	c.319G>A	c.(319-321)Gtg>Atg	p.V107M		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCCTCCTCGGTGGTACCCAA	0.488000													30	269					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179430142	179430142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179430142C>T	ENST00000589042.1	-	326	80941	c.80717G>A	c.(80716-80718)cGa>cAa	p.R26906Q	TTN_ENST00000342992.6_Missense_Mutation_p.R24338Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R17841Q|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R18033Q|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R17966Q|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R25265Q|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25265							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGTCTTGGTCGGCCTATAAC	0.383000													27	80					0	0	1	0	0
FABP12	646486	broad.mit.edu	37	8	82441730	82441730	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:82441730G>A	ENST00000360464.4	-	2	251	c.189C>T	c.(187-189)atC>atT	p.I63I	RP11-257P3.3_ENST00000523380.1_RNA	NM_001105281.1	NP_001098751.1	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	63							lipid binding|transporter activity			large_intestine(1)|lung(3)	4						GCTTAAAGGAGATCTCATTAT	0.428000													45	97					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40944474	40944474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40944474G>A	ENST00000373198.3	-	12	2263	c.2028C>T	c.(2026-2028)acC>acT	p.T676T	PTPRT_ENST00000373193.3_Silent_p.T676T|PTPRT_ENST00000373184.1_Silent_p.T676T|PTPRT_ENST00000373201.1_Silent_p.T676T|PTPRT_ENST00000373190.1_Silent_p.T676T|PTPRT_ENST00000373187.1_Silent_p.T676T|PTPRT_ENST00000356100.2_Silent_p.T676T	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	676	Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TAAATGGCTGGGTGACAGGCA	0.517000													52	90					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48414342	48414342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48414342G>A	ENST00000249598.1	-	2	685	c.526C>T	c.(526-528)Ctg>Ttg	p.L176L		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	176					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						GTTCCATCCAGAACATCATAA	0.522000													16	43					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875795	247875795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247875795C>T	ENST00000302084.2	-	1	310	c.263G>A	c.(262-264)aGa>aAa	p.R88K	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGTCTGACTTCTCCCCAGTAG	0.478000													33	79					0	0	1	0	0
FAM188A	80013	broad.mit.edu	37	10	15828640	15828640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15828640G>A	ENST00000378036.1	-	4	1327	c.151C>T	c.(151-153)Ctc>Ttc	p.L51F	FAM188A_ENST00000277632.3_Missense_Mutation_p.L346F|FAM188A_ENST00000477891.1_5'UTR			Q9H8M7	F188A_HUMAN	family with sequence similarity 188, member A	346					apoptosis	nucleus	calcium ion binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	22						TTCTTCATGAGATTTATACTA	0.328000													19	103					0	0	1	0	0
ALG13	79868	broad.mit.edu	37	X	110988108	110988108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:110988108C>T	ENST00000394780.3	+	24	2920	c.2908C>T	c.(2908-2910)Cca>Tca	p.P970S	ALG13_ENST00000470971.1_3'UTR|ALG13_ENST00000251943.4_Intron	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	970	Pro-rich.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						TTCCTGTGATCCAAGCGGCAG	0.463000													6	8					0	0	1	0	0
OR5K3	403277	broad.mit.edu	37	3	98110023	98110023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98110023C>T	ENST00000383695.1	+	1	514	c.514C>T	c.(514-516)Cat>Tat	p.H172Y	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005516.1	NP_001005516.1	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K, member 3	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|prostate(1)|skin(1)|urinary_tract(1)	27						CTGTGGGTCTCATCAAATCAA	0.388000													38	103					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70502256	70502256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70502256C>T	ENST00000310961.5	+	21	2556	c.2138C>T	c.(2137-2139)tCc>tTc	p.S713F	LRRC7_ENST00000415775.2_Intron|LRRC7_ENST00000035383.5_Missense_Mutation_p.S708F			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	708						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AAAGTGGGGTCCTTGCAGACA	0.448000													43	102					0	0	1	0	0
ENPP4	22875	broad.mit.edu	37	6	46107906	46107906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46107906G>A	ENST00000321037.4	+	2	816	c.586G>A	c.(586-588)Gga>Aga	p.G196R		NM_014936.4	NP_055751.1	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)	196						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	18						CCACAAATACGGACCTGAAGA	0.383000													43	89					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150948210	150948210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150948210G>A	ENST00000261800.5	-	1	295	c.283C>T	c.(283-285)Cta>Tta	p.L95L		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	95	Cadherin 1.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTATTCTTAGGAAGCAGAAG	0.512000													41	322					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36348748	36348748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36348748G>A	ENST00000360631.3	-	17	2358	c.2147C>T	c.(2146-2148)cCc>cTc	p.P716L	DCLK1_ENST00000379893.1_Missense_Mutation_p.P409L|DCLK1_ENST00000255448.4_3'UTR			O15075	DCLK1_HUMAN	doublecortin-like kinase 1	716					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GTTGAGTTCGGGAGGAGCTGG	0.552000													3	5					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813687	123813687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123813687G>A	ENST00000321252.2	-	1	893	c.859C>T	c.(859-861)Cca>Tca	p.P287S		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AAGATGAATGGGTTCAAGAGG	0.522000													26	227					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088532	94088532	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94088532G>A	ENST00000553484.1	+	31	5173	c.5019G>A	c.(5017-5019)acG>acA	p.T1673T	UNC79_ENST00000555664.1_Silent_p.T1651T|UNC79_ENST00000393151.2_Silent_p.T1651T|UNC79_ENST00000256339.4_Silent_p.T1474T			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1651						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AAGAGGAGACGATGAACCAAG	0.552000													35	91					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16026284	16026284	+	Missense_Mutation	SNP	C	C	T	rs13306549		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16026284C>T	ENST00000350896.3	-	4	510	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	MSR1_ENST00000445506.2_Missense_Mutation_p.E123K|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000381998.4_Missense_Mutation_p.E105K|MSR1_ENST00000262101.5_Missense_Mutation_p.E105K|MSR1_ENST00000355282.2_Missense_Mutation_p.E105K	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	105	Spacer (Probable).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTTCCTCTTCGCTGTCATTT	0.403000													99	94					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825276	4825276	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4825276G>A	ENST00000380382.1	-	1	571	c.572C>T	c.(571-573)tCt>tTt	p.S191F	MMP26_ENST00000380390.1_Intron|OR52R1_ENST00000356069.2_Missense_Mutation_p.S112F|MMP26_ENST00000477339.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGACTCCACAGAAGAAAAGGC	0.522000													27	98					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149499582	149499582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149499582G>A	ENST00000261799.4	-	19	3160	c.2691C>T	c.(2689-2691)ttC>ttT	p.F897F		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	897	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TACCCAAGGTGAAGATCTCCC	0.582000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								12	75					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1246031	1246031	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1246031C>T	ENST00000324642.3	+	12	1848	c.1725C>T	c.(1723-1725)tcC>tcT	p.S575S		NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	575					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGCTGCTGTCCTTGCTGCCCG	0.716000													13	22					0	0	1	0	0
RNF141	50862	broad.mit.edu	37	11	10555624	10555624	+	Nonsense_Mutation	SNP	G	G	A	rs144898917		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10555624G>A	ENST00000265981.2	-	2	224	c.82C>T	c.(82-84)Cga>Tga	p.R28*	RNF141_ENST00000528665.1_Nonsense_Mutation_p.R28*	NM_016422.3	NP_057506.2	Q8WVD5	RN141_HUMAN	ring finger protein 141	28							zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|urinary_tract(1)	9				all cancers(16;4.63e-08)|Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.064)		CCACTCTCTCGAACCAACGTA	0.383000													58	119					0	0	1	0	0
DGCR14	8220	broad.mit.edu	37	22	19125809	19125809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19125809G>A	ENST00000252137.6	-	7	887	c.844C>T	c.(844-846)Ccc>Tcc	p.P282S		NM_022719.2	NP_073210.1	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region gene 14	282					nervous system development	catalytic step 2 spliceosome				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	16	Colorectal(54;0.0993)					TTGCCATCGGGGCCCACCTTG	0.627000													10	28					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473672	19473672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:19473672G>A	ENST00000507958.1	-	15	3026	c.2036C>T	c.(2035-2037)cCt>cTt	p.P679L	CDH18_ENST00000382275.1_Missense_Mutation_p.P679L|CDH18_ENST00000274170.4_Missense_Mutation_p.P679L|CDH18_ENST00000510297.1_5'UTR			Q13634	CAD18_HUMAN	cadherin 18, type 2	679					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGCAGCAGAAGGATTCCTCAA	0.507000													51	97					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74468459	74468459	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74468459C>A	ENST00000249842.3	+	2	1617	c.1260C>A	c.(1258-1260)ctC>ctA	p.L420L	RP11-665J16.1_ENST00000561647.1_RNA|ISLR_ENST00000395118.1_Silent_p.L420L	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	420					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						AAAGCCTCCTCCTCTTCTTCT	0.637000													34	31					9.17885e-22	9.23747e-22	1	1	0
TMEM180	79847	broad.mit.edu	37	10	104230740	104230740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104230740C>T	ENST00000238936.4	+	5	807	c.570C>T	c.(568-570)tcC>tcT	p.S190S	TMEM180_ENST00000369931.3_Intron|TMEM180_ENST00000366277.2_Intron	NM_024789.3	NP_079065.2	Q14CX5	TM180_HUMAN	transmembrane protein 180	190						integral to membrane				breast(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|skin(1)	13		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		AGGATTTCTCCTCCTTCCGCG	0.617000													48	114					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7682521	7682521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7682521G>A	ENST00000446248.2	+	18	3600	c.3499G>A	c.(3499-3501)Gaa>Aaa	p.E1167K	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.E1140K	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	1140	CKK.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CAAGGTGAACGAACCGCAGAA	0.597000													11	35					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1095344	1095344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1095344C>T	ENST00000441003.2	+	32	6191	c.6164C>T	c.(6163-6165)cCt>cTt	p.P2055L	MUC2_ENST00000361558.6_Missense_Mutation_p.P193L|MUC2_ENST00000333592.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4417						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GACTTTGATCCTCCCAGACAG	0.682000													8	27					0	0	1	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543331	182543331	+	Missense_Mutation	SNP	G	G	A	rs147793698	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182543331G>A	ENST00000295108.3	-	2	714	c.257C>T	c.(256-258)cCc>cTc	p.P86L	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	86					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CTTCTTTTTGGGGCCGCGTCT	0.562000													7	35					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164783108	164783108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164783108G>A	ENST00000264382.3	-	7	810	c.748C>T	c.(748-750)Cgt>Tgt	p.R250C		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	250	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.R250C(2)		NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AAATCATGACGAAATCTCTTA	0.343000										HNSCC(35;0.089)			27	47					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142486068	142486068	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142486068C>T	ENST00000430863.1	-	0	1705					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GGGTCCCCAGCCCTGGTGCGT	0.602000													5	18					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52601976	52601976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:52601976G>A	ENST00000395961.3	-	7	1156	c.990C>T	c.(988-990)tcC>tcT	p.S330S	BCAS1_ENST00000434986.2_Silent_p.S88S|BCAS1_ENST00000371440.3_Silent_p.S375S|BCAS1_ENST00000371435.2_Silent_p.S330S	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	330						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			GGGTCTCCTGGGATGTAAAGT	0.493000													75	173					0	0	1	0	0
RP11-50E11.3	0	broad.mit.edu	37	10	52389396	52389396	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52389396C>T	ENST00000443374.1	+	0	89																											CCCCAAGCTCCTCTATCAGAG	0.547000													25	53					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50962182	50962182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50962182C>T	ENST00000357701.5	+	22	2565	c.2514C>T	c.(2512-2514)ccC>ccT	p.P838P		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	838	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CAGAGCCACCCAAGATCCGGC	0.667000													3	17					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707821	50707821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50707821G>A	ENST00000330943.4	-	4	618	c.447C>T	c.(445-447)ttC>ttT	p.F149F	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	149	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						TCTCCTCAGCGAAGTTCCCAG	0.617000													7	41					0	0	1	0	0
RSAD1	55316	broad.mit.edu	37	17	48559733	48559733	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48559733C>T	ENST00000258955.2	+	4	841	c.756C>T	c.(754-756)ctC>ctT	p.L252L		NM_018346.1	NP_060816.1	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing 1	252					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			ACCCGGAGCTCGCAGCTGAGA	0.647000											OREG0024567	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	79					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133894781	133894781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133894781C>T	ENST00000220616.4	+	7	853	c.813C>T	c.(811-813)ttC>ttT	p.F271F	TG_ENST00000377869.1_Silent_p.F271F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	271	Thyroglobulin type-1 3.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTTCCACCTTCACTGAAACCA	0.458000													21	228					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120984322	120984322	+	Missense_Mutation	SNP	G	G	A	rs150098939	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120984322G>A	ENST00000392793.1	+	6	956	c.685G>A	c.(685-687)Gag>Aag	p.E229K	TECTA_ENST00000264037.2_Missense_Mutation_p.E229K			O75443	TECTA_HUMAN	tectorin alpha	229	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AAGAACCCCCGAGATCGTGAA	0.478000													10	69					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51173447	51173447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51173447C>T	ENST00000440970.1	-	2	2826	c.2395G>A	c.(2395-2397)Gat>Aat	p.D799N	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.D896N|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	896					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GTCAGGACATCCCCCTCGATG	0.537000													17	53					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8530212	8530212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8530212C>T	ENST00000348943.3	+	6	675	c.443C>T	c.(442-444)cCt>cTt	p.P148L	HNRNPM_ENST00000325495.4_Missense_Mutation_p.P148L	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	148	RRM 1.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						TTTTAGGATCCTGATGGTGAA	0.463000													17	176					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765443	18765443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18765443C>T	ENST00000304081.4	-	5	902	c.802G>A	c.(802-804)Gag>Aag	p.E268K	NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.E328K|NT5C1B_ENST00000600945.1_Missense_Mutation_p.E328K|NT5C1B_ENST00000359846.2_Missense_Mutation_p.E328K	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CCCTCTTGCTCGTAGATTTTC	0.552000													52	149					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48719832	48719832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48719832G>A	ENST00000316623.5	-	58	7591	c.7136C>T	c.(7135-7137)cCt>cTt	p.P2379L		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2379	TB 9.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCCCTGGAAAGGGCAGATCTC	0.527000													8	79					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29787322	29787322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29787322G>A	ENST00000269202.6	+	8	702	c.655G>A	c.(655-657)Gga>Aga	p.G219R	MEP1B_ENST00000581447.1_Missense_Mutation_p.G219R	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	219	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						ATTCCAAAATGGAACAGAGCC	0.393000													9	23					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122808458	122808458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122808458C>T	ENST00000194130.2	-	6	669	c.630G>A	c.(628-630)ggG>ggA	p.G210G	SLC13A1_ENST00000539873.1_Silent_p.G146G	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	210						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TTGAAATTTTCCCTGTATCAT	0.254000													16	78					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119033623	119033623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119033623G>A	ENST00000328252.3	+	9	3250	c.2881G>A	c.(2881-2883)Gac>Aac	p.D961N	PAPPA_ENST00000534838.1_5'UTR	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	961					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TGAACAATGCGACGACATGAA	0.448000													48	122					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40193564	40193564	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:40193564C>T	ENST00000360214.3	+	10	1590	c.1130C>T	c.(1129-1131)tCc>tTc	p.S377F	ETS2_ENST00000360938.3_Missense_Mutation_p.S377F	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	377					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TCAGACAAATCCTGCCAGTCA	0.547000													62	110					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89256747	89256747	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89256747C>T	ENST00000289746.2	+	8	1140	c.1075C>T	c.(1075-1077)Cag>Tag	p.Q359*		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	359	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		TGAGCGGGGCCAGGCCAAGGT	0.647000													9	20					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6007673	6007673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6007673C>T	ENST00000332249.4	-	1	542	c.488G>A	c.(487-489)gGa>gAa	p.G163E		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACCACCATTCCGATGCACCC	0.512000													6	85					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52579321	52579321	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52579321G>A	ENST00000313234.5	-	2	448	c.351C>T	c.(349-351)ttC>ttT	p.F117F	KRT80_ENST00000394815.2_Silent_p.F117F	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	117	Coil 1A.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		GGCCCTGCAGGAAGCTCCAGC	0.637000													7	43					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161123349	161123349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161123349G>A	ENST00000308192.9	+	1	76	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	PLG_ENST00000462918.1_3'UTR|PLG_ENST00000366924.2_Missense_Mutation_p.E5K	NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	5					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGAACATAAGGAAGTGGTTCT	0.368000													43	65					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39504228	39504228	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:39504228G>A	ENST00000518318.2	+	10	1953	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	POU6F2_ENST00000559001.1_Silent_p.E618E|POU6F2_ENST00000403058.1_Silent_p.E673E			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	673					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						AACAGCACGAGCCGGCCACGG	0.453000													8	10					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350174	51350174	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51350174G>A	ENST00000327536.5	-	3	882	c.783C>T	c.(781-783)ttC>ttT	p.F261F	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	261										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		GGGTGGAGAGGAACTCCACAT	0.517000													26	61					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16910720	16910720	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16910720G>A	ENST00000524140.2	+	17	3901	c.3483G>A	c.(3481-3483)ggG>ggA	p.G1161G	NWD1_ENST00000523826.1_Silent_p.G955G|NWD1_ENST00000379808.3_Silent_p.G1161G|NWD1_ENST00000339803.6_Silent_p.G1026G|NWD1_ENST00000552788.1_Silent_p.G1161G|NWD1_ENST00000549814.1_Intron	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1161							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAGAACAGGGGACCCTTCTGG	0.577000													20	46					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48556366	48556366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48556366C>T	ENST00000435803.1	+	52	13710	c.13686C>T	c.(13684-13686)tcC>tcT	p.S4562S	ABCA13_ENST00000544596.1_Silent_p.S292S	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4562					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GAATCTTTTCCAGTTCGGACG	0.388000													59	173					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1996226	1996226	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1996226C>T	ENST00000382722.5	-	7	1153	c.791G>A	c.(790-792)tGg>tAg	p.W264*	CACNA2D4_ENST00000586184.1_Nonsense_Mutation_p.W264*|CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000585708.1_Nonsense_Mutation_p.W200*|CACNA2D4_ENST00000587995.1_Nonsense_Mutation_p.W264*|CACNA2D4_ENST00000588077.1_Nonsense_Mutation_p.W200*	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	264						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity	p.W264*(1)		endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		ATCAGGTGTCCATTTTATACC	0.517000													3	11					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74659801	74659801	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74659801G>A	ENST00000268053.6	-	1	280	c.126C>T	c.(124-126)acC>acT	p.T42T	CYP11A1_ENST00000467407.1_5'UTR|CYP11A1_ENST00000541301.1_Silent_p.T42T	NM_000781.2	NP_000772.2	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	42					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GAGGACTGCGGGTGGAGATGC	0.622000													52	57					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117876	20117876	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20117876G>A	ENST00000397165.2	-	4	595	c.435C>T	c.(433-435)ttC>ttT	p.F145F	ZNF682_ENST00000358523.5_Silent_p.F113F|ZNF682_ENST00000595736.1_Silent_p.F69F|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000397162.1_Silent_p.F113F|ZNF682_ENST00000597972.1_Silent_p.F151F	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TATTATATGGGAAAATTTTGC	0.308000													20	44					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12384536	12384536	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12384536G>A	ENST00000356109.5	-	5	796	c.678C>T	c.(676-678)ttC>ttT	p.F226F	ZNF44_ENST00000355684.5_Silent_p.F178F	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		CAGGAGAACTGAAGGTTTTTC	0.413000													22	80					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47293917	47293917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47293917G>A	ENST00000225941.1	+	2	640	c.142G>A	c.(142-144)Gag>Aag	p.E48K	ABI3_ENST00000419580.2_Missense_Mutation_p.E48K	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	48					cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			GAAGGCGCTGGAGGAGACCAT	0.647000										HNSCC(55;0.14)			7	19					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328076	80328076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:80328076C>T	ENST00000358842.3	-	1	1296	c.1279G>A	c.(1279-1281)Gga>Aga	p.G427R		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	427					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						TTGGTCATTCCTCCATCTACC	0.418000													17	127					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117825450	117825450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117825450C>T	ENST00000350763.4	-	13	4190	c.3779G>A	c.(3778-3780)gGa>gAa	p.G1260E	TNC_ENST00000341037.4_Intron|TNC_ENST00000542877.1_Intron|TNC_ENST00000340094.3_Intron|TNC_ENST00000537320.1_Intron|TNC_ENST00000535648.1_Intron|TNC_ENST00000423613.2_Missense_Mutation_p.G1260E|TNC_ENST00000345230.3_Intron|TNC_ENST00000346706.3_Intron	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1260	Fibronectin type-III 8.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TGTGAGGTTTCCCATATCTGG	0.493000													14	33					0	0	1	0	0
DEAF1	10522	broad.mit.edu	37	11	688045	688045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:688045G>A	ENST00000382409.3	-	4	1014	c.530C>T	c.(529-531)cCt>cTt	p.P177L	DEAF1_ENST00000338675.6_Missense_Mutation_p.P177L	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	177					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		AGGGGTTGGAGGAGACTGAGG	0.572000													18	38					0	0	1	0	0
GAS2	2620	broad.mit.edu	37	11	22759280	22759280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:22759280C>T	ENST00000454584.2	+	5	744	c.439C>T	c.(439-441)Ctc>Ttc	p.L147F	GAS2_ENST00000278187.3_Missense_Mutation_p.L147F|GAS2_ENST00000433790.1_Missense_Mutation_p.L147F	NM_001143830.1	NP_001137302.1	O43903	GAS2_HUMAN	growth arrest-specific 2	147	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(4)|stomach(1)	24						AGAAGTGTGTCTCTGTCTGCT	0.488000													37	82					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89968486	89968486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89968486G>A	ENST00000405460.2	+	22	4972	c.4876G>A	c.(4876-4878)Gac>Aac	p.D1626N	GPR98_ENST00000450321.2_3'UTR	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1626	Calx-beta 11.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCTTGTTGATGACTTTGCTAA	0.403000													38	79					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30962216	30962216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30962216C>T	ENST00000311813.4	+	3	642	c.587C>T	c.(586-588)tCc>tTc	p.S196F	AQP1_ENST00000509504.1_Missense_Mutation_p.S373F|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Missense_Mutation_p.S145F|AQP1_ENST00000409899.1_Missense_Mutation_p.S81F|AQP1_ENST00000441328.2_Missense_Mutation_p.S113F|AQP1_ENST00000434909.2_Missense_Mutation_p.S256F	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				CCTGCTCGGTCCTTTGGCTCC	0.567000													97	263					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546350	11546350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11546350G>A	ENST00000389362.4	-	3	697	c.662C>T	c.(661-663)cCa>cTa	p.P221L	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGTCCTTGTGGCTTTCCTGG	0.612000													39	314					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34061368	34061368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34061368C>T	ENST00000397527.1	+	13	2099	c.1379C>T	c.(1378-1380)tCt>tTt	p.S460F	CEP250_ENST00000342580.4_Missense_Mutation_p.S460F	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	460					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAGGTGGACTCTCTCAGCAAG	0.597000													5	17					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10550730	10550730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10550730C>T	ENST00000583535.1	-	9	836	c.749G>A	c.(748-750)cGa>cAa	p.R250Q	MYH3_ENST00000226209.7_Missense_Mutation_p.R250Q	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	250	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.R250Q(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						AAAATGGATTCGGATGAACTT	0.483000													23	32					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87241866	87241866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87241866C>T	ENST00000297524.3	-	1	744	c.641G>A	c.(640-642)gGa>gAa	p.G214E	SLC7A13_ENST00000419776.2_Missense_Mutation_p.G214E|SLC7A13_ENST00000520624.1_Intron	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	214						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						TGCAAAATATCCTTGGAAGAT	0.363000													33	109					0	0	1	0	0
OR6C75	390323	broad.mit.edu	37	12	55759599	55759599	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55759599C>G	ENST00000343399.3	+	1	705	c.705C>G	c.(703-705)gcC>gcG	p.A235A		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	235			A -> D (in dbSNP:rs7976416).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						GGAAAAAAGCCTTTTCCACTT	0.393000													27	52					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47663777	47663777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47663777C>T	ENST00000273857.4	-	12	1685	c.1686G>A	c.(1684-1686)gaG>gaA	p.E562E	CORIN_ENST00000502252.1_Silent_p.E495E|CORIN_ENST00000505909.1_Silent_p.E525E|CORIN_ENST00000504584.1_Silent_p.E525E|CORIN_ENST00000508498.1_Silent_p.E423E	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	562	FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						CTGAATTTTCCTCTGGAAATT	0.413000													25	72					0	0	1	0	0
OPALIN	93377	broad.mit.edu	37	10	98105809	98105809	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98105809C>T	ENST00000419479.1	-	7	792	c.285G>A	c.(283-285)gtG>gtA	p.V95V	OPALIN_ENST00000393870.2_Silent_p.V94V|OPALIN_ENST00000393871.1_Silent_p.V82V|OPALIN_ENST00000371172.3_Silent_p.V105V|OPALIN_ENST00000536387.1_Silent_p.V95V	NM_001040103.1	NP_001035192.1	Q96PE5	OPALI_HUMAN	oligodendrocytic myelin paranodal and inner loop protein	105						Golgi apparatus|integral to membrane|plasma membrane				breast(1)|large_intestine(1)|lung(5)|prostate(2)	9						CTACAGTCTTCACATATATGT	0.453000													56	150					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298516	107298516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107298516G>A	ENST00000374781.2	-	1	621	c.579C>T	c.(577-579)gcC>gcT	p.A193A		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						GCAGTCTCATGGCAAGTAATG	0.433000													53	114					0	0	1	0	0
COG2	22796	broad.mit.edu	37	1	230798890	230798890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230798890C>T	ENST00000534989.1	+	4	462	c.127C>T	c.(127-129)Ctt>Ttt	p.L43F	COG2_ENST00000366669.4_Missense_Mutation_p.L102F|COG2_ENST00000535166.1_5'UTR|COG2_ENST00000366668.3_Missense_Mutation_p.L102F|COG2_ENST00000494371.1_3'UTR			Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	102					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TTTAAAGAGCCTTAGATCGTC	0.318000													9	64					0	0	1	0	0
SPARCL1	8404	broad.mit.edu	37	4	88415537	88415537	+	Missense_Mutation	SNP	C	C	T	rs140130359		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88415537C>T	ENST00000418378.1	-	5	986	c.415G>A	c.(415-417)Gat>Aat	p.D139N	SPARCL1_ENST00000282470.6_Missense_Mutation_p.D139N|SPARCL1_ENST00000503414.1_Missense_Mutation_p.D14N	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	139					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		GCCAAAAAATCAGTGTTCTCT	0.378000													51	119					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51189562	51189562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51189562C>T	ENST00000293441.1	-	20	2527	c.2509G>A	c.(2509-2511)Gaa>Aaa	p.E837K	SHANK1_ENST00000391813.1_Missense_Mutation_p.E224K|SHANK1_ENST00000359082.3_Missense_Mutation_p.E828K|SHANK1_ENST00000391814.1_Missense_Mutation_p.E845K	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	837					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CCAGGGCTTTCGCTTGCACTG	0.562000													26	57					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	601380	601380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:601380C>T	ENST00000219611.2	+	8	2508	c.2145C>T	c.(2143-2145)ccC>ccT	p.P715P	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		GCCTGCGCCCCCGGCATGCCT	0.677000													20	41					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914329	107914329	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107914329G>A	ENST00000280758.5	+	2	1729	c.1201G>A	c.(1201-1203)Gaa>Aaa	p.E401K	BTBD11_ENST00000420571.2_Missense_Mutation_p.E401K|BTBD11_ENST00000490090.2_Missense_Mutation_p.E401K	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	401						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CAAGCCAGGGGAACTGCCCAT	0.552000													16	126					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6078444	6078444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6078444G>A	ENST00000261405.5	-	45	7916	c.7662C>T	c.(7660-7662)gtC>gtT	p.V2554V		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2554					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GGCAGACAGGGACCTCCAGCT	0.617000													10	39					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141006949	141006949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:141006949C>T	ENST00000277549.5	+	40	5679	c.3110C>T	c.(3109-3111)cCc>cTc	p.P1037L	CACNA1B_ENST00000277551.2_Missense_Mutation_p.P1843L|CACNA1B_ENST00000371372.1_Missense_Mutation_p.P1843L|CACNA1B_ENST00000371363.1_Missense_Mutation_p.P1841L|CACNA1B_ENST00000371365.2_3'UTR|CACNA1B_ENST00000371355.4_Missense_Mutation_p.P1844L|CACNA1B_ENST00000371357.1_Missense_Mutation_p.P1842L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1843					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTGGTACCACCCCATAAGCGT	0.577000													15	28					0	0	1	0	0
ESM1	11082	broad.mit.edu	37	5	54277897	54277897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54277897C>T	ENST00000381405.4	-	2	524	c.379G>A	c.(379-381)Gga>Aga	p.G127R	ESM1_ENST00000381403.4_Intron|ESM1_ENST00000598310.1_Intron	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	127					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			AGGCATTTTCCCGTCCCCCTG	0.493000													49	109					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149883447	149883447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149883447G>A	ENST00000369146.3	-	3	1198	c.708C>T	c.(706-708)ctC>ctT	p.L236L	SV2A_ENST00000369145.1_Silent_p.L236L	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	236					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	AGAGCGAGATGAGCAGACACT	0.587000													15	51					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321852	78321852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78321852C>T	ENST00000582970.1	+	29	9860	c.9717C>T	c.(9715-9717)ccC>ccT	p.P3239P	RNF213_ENST00000508628.2_Silent_p.P3288P|RNF213_ENST00000336301.6_Silent_p.P1312P	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGCAGGGTCCCCGGGCCTTGA	0.617000													17	49					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81654595	81654595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81654595G>A	ENST00000558726.1	-	4	495	c.360C>T	c.(358-360)ttC>ttT	p.F120F	TMC3_ENST00000359440.5_Silent_p.F120F			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	120						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						CCCAGGGAATGAAGATGACCA	0.483000													12	19					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105405844	105405844	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105405844A>G	ENST00000333244.5	-	7	16063	c.15944T>C	c.(15943-15945)cTt>cCt	p.L5315P	AHNAK2_ENST00000557457.1_Missense_Mutation_p.L313P	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5315						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGTTTCTGGAAGCCTCATGCC	0.507000													19	31					0	0	1	0	0
PTCD2	79810	broad.mit.edu	37	5	71616244	71616244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71616244C>T	ENST00000380639.5	+	1	51	c.35C>T	c.(34-36)cCc>cTc	p.P12L	PTCD2_ENST00000503868.1_Missense_Mutation_p.P12L|PTCD2_ENST00000543322.1_Missense_Mutation_p.P12L|PTCD2_ENST00000536805.1_5'UTR	NM_024754.3	NP_079030.3	Q8WV60	PTCD2_HUMAN	pentatricopeptide repeat domain 2	12										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(1)|skin(1)	11		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.73e-53)		GCATTTCGGCCCTCGAATCGA	0.622000													12	51					0	0	1	0	0
OR51F2	119694	broad.mit.edu	37	11	4842683	4842683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4842683C>T	ENST00000322110.5	+	1	133	c.68C>T	c.(67-69)cCt>cTt	p.P23L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTGCTGAGCCTCTGATCTTC	0.438000													115	272					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153661466	153661466	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153661466C>T	ENST00000368680.3	+	16	2927	c.2455C>T	c.(2455-2457)Cgc>Tgc	p.R819C		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	819					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CCTGCTGTCCCGCATGGAGCA	0.627000													38	156					0	0	1	0	0
PSTPIP2	9050	broad.mit.edu	37	18	43591154	43591154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43591154C>T	ENST00000409746.5	-	5	418	c.347G>A	c.(346-348)cGa>cAa	p.R116Q	PSTPIP2_ENST00000589328.1_Missense_Mutation_p.R116Q|PSTPIP2_ENST00000588801.1_5'UTR	NM_024430.3	NP_077748.3	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting protein 2	116						membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	17						AACCTTTTTTCGTTGTAGTTT	0.428000													16	198					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79290481	79290481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79290481C>T	ENST00000419573.3	-	20	3245	c.2971G>A	c.(2971-2973)Gag>Aag	p.E991K	RASGRF1_ENST00000558480.2_Missense_Mutation_p.E975K|RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000394745.3_Missense_Mutation_p.E207K	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	993					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GTCAGGAGCTCCGGGTCGTGC	0.587000													29	150					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83221249	83221249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83221249C>T	ENST00000563800.1	-	8	2987	c.1262G>A	c.(1261-1263)cGa>cAa	p.R421Q	CPEB1_ENST00000568757.1_Missense_Mutation_p.R319Q|CPEB1_ENST00000568128.1_Missense_Mutation_p.R394Q|CPEB1_ENST00000562019.1_Missense_Mutation_p.R399Q|CPEB1_ENST00000423133.2_Missense_Mutation_p.R319Q|CPEB1_ENST00000398591.2_Missense_Mutation_p.R324Q|CPEB1_ENST00000398592.2_Missense_Mutation_p.R168Q|CPEB1_ENST00000450751.2_Missense_Mutation_p.R319Q|CPEB1_ENST00000261723.6_Missense_Mutation_p.R397Q|RP11-152F13.10_ENST00000562833.1_Missense_Mutation_p.E129K|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000564522.1_Missense_Mutation_p.R319Q			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	399	Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			GCGCATCCTTCGGCTGGACAT	0.502000													7	77					0	0	1	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186862233	186862233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186862233C>T	ENST00000367466.3	+	4	358	c.206C>T	c.(205-207)cCt>cTt	p.P69L	PLA2G4A_ENST00000466600.1_3'UTR|PLA2G4A_ENST00000442353.2_Missense_Mutation_p.P69L	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	69	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	GACATAAACCCTGTGTGGAAT	0.378000													68	217					0	0	1	0	0
HSF2BP	11077	broad.mit.edu	37	21	44949807	44949807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:44949807G>A	ENST00000291560.2	-	9	1163	c.832C>T	c.(832-834)Ctt>Ttt	p.L278F	HSF2BP_ENST00000542962.1_Missense_Mutation_p.L203F	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	278					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		GACTGGACAAGCCTCAGTACA	0.458000													24	49					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975912	20975912	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20975912C>T	ENST00000261383.3	-	53	9293	c.9294G>A	c.(9292-9294)gcG>gcA	p.A3098A	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3098	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.A3098A(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCAGTTTATTCGCCTTCTCCA	0.468000													43	107					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5457778	5457778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:5457778C>T	ENST00000296564.7	+	12	1247	c.1025C>T	c.(1024-1026)cCt>cTt	p.P342L		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	342	Pro-rich.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						CTTCCCCCTCCTCTTCTGTCA	0.463000													22	275					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179500409	179500409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179500409C>T	ENST00000589042.1	-	227	41866	c.41642G>A	c.(41641-41643)cGa>cAa	p.R13881Q	TTN_ENST00000342992.6_Missense_Mutation_p.R11313Q|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R4816Q|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R5008Q|TTN_ENST00000359218.5_Missense_Mutation_p.R4941Q|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R12240Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12240							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGCTGGTCTCGTATAGGTTT	0.358000													8	13					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064619	9064619	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9064619G>A	ENST00000397910.4	-	3	23030	c.22827C>T	c.(22825-22827)gcC>gcT	p.A7609A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7611	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGACAGAGGAGGCAGAAATCC	0.478000													22	65					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48248804	48248804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48248804G>A	ENST00000394747.1	-	8	1585	c.1236C>T	c.(1234-1236)ctC>ctT	p.L412L	ABCC11_ENST00000537808.1_Silent_p.L412L|ABCC11_ENST00000353782.5_Silent_p.L412L|ABCC11_ENST00000394748.1_Silent_p.L412L|ABCC11_ENST00000356608.2_Silent_p.L412L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	412	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TTGACGCTGTGAGTTTCAGCT	0.502000													18	41					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54153116	54153116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:54153116G>A	ENST00000404125.1	-	13	1693	c.1638C>T	c.(1636-1638)ttC>ttT	p.F546F	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	546					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ACTGTAAGACGAAATCCTCAA	0.363000													18	61					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38144728	38144728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38144728C>T	ENST00000379747.4	-	19	2375	c.2258G>A	c.(2257-2259)cGa>cAa	p.R753Q	POSTN_ENST00000379742.4_Missense_Mutation_p.R696Q|POSTN_ENST00000541179.1_Missense_Mutation_p.R726Q|POSTN_ENST00000379743.4_Missense_Mutation_p.R726Q|POSTN_ENST00000497145.1_5'UTR|POSTN_ENST00000379749.4_Missense_Mutation_p.R753Q|POSTN_ENST00000541481.1_Intron	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	753					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TGTAATGATTCGTTCTTCTCG	0.318000													17	88					0	0	1	0	0
DYX1C1	161582	broad.mit.edu	37	15	55727241	55727241	+	Silent	SNP	C	C	T	rs138026922		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:55727241C>T	ENST00000321149.3	-	8	1276	c.909G>A	c.(907-909)acG>acA	p.T303T	DYX1C1_ENST00000448430.2_Silent_p.T303T|DYX1C1_ENST00000348518.3_Silent_p.T303T|DYX1C1-CCPG1_ENST00000565113.1_RNA|DYX1C1_ENST00000457155.2_Silent_p.T303T|DYX1C1_ENST00000380679.1_Silent_p.T303T	NM_130810.3	NP_570722.2	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1	303					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		AATAGTTTTCCGTTGCAAACA	0.318000													18	62					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217124258	217124258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:217124258G>A	ENST00000273067.4	-	4	2776	c.1010C>T	c.(1009-1011)tCc>tTc	p.S337F		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	337						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GGTGGATGAGGAGGTCCGGGG	0.637000													11	29					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41594836	41594836	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41594836C>T	ENST00000330436.3	+	2	183	c.183C>T	c.(181-183)atC>atT	p.I61I		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	61					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	TCCAACAGATCAGTGAGCGCT	0.612000													20	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179553422	179553422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179553422C>T	ENST00000589042.1	-	126	32403	c.32179G>A	c.(32179-32181)Gaa>Aaa	p.E10727K	TTN_ENST00000342992.6_Missense_Mutation_p.E9483K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10410K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10410	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCGTGACTTCCACTCTTTGA	0.388000													34	53					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185902943	185902943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:185902943C>T	ENST00000271588.4	+	11	2044	c.1815C>T	c.(1813-1815)ttC>ttT	p.F605F	HMCN1_ENST00000367492.2_Silent_p.F605F	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	605	Ig-like C2-type 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTTCAGTTTTCCTCACAGTGC	0.398000													50	186					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43251399	43251399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43251399G>A	ENST00000259750.4	+	14	3004	c.2921G>A	c.(2920-2922)gGg>gAg	p.G974E		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	974						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GTGGAGGAGGGGGCCCGAGCG	0.687000													33	44					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23871841	23871841	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23871841C>T	ENST00000354639.3	+	24	3311	c.2847C>T	c.(2845-2847)ttC>ttT	p.F949F	STK31_ENST00000433467.2_Silent_p.F949F|STK31_ENST00000355870.3_Silent_p.F972F|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Silent_p.F949F	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	972	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CTGAATGTTTCTTGATGCCAA	0.353000													24	69					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222821	140222821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140222821G>A	ENST00000531613.1	+	1	1915	c.1915G>A	c.(1915-1917)Gaa>Aaa	p.E639K	PCDHA8_ENST00000378123.3_Missense_Mutation_p.E639K|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCCTGGACGAAGCGGACTC	0.647000													49	41					0	0	1	0	0
DPT	1805	broad.mit.edu	37	1	168698157	168698157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168698157C>T	ENST00000367817.3	-	1	345	c.256G>A	c.(256-258)Gaa>Aaa	p.E86K		NM_001937.4	NP_001928.2	Q07507	DERM_HUMAN	dermatopontin	86	2 X 53-55 AA tandem repeats.|3 X 6 AA repeats of D-R-[EQ]-W-[NQK]- [FY].				cell adhesion	extracellular space|proteinaceous extracellular matrix				kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					TCCGTGGGTTCCCCGAGGCTC	0.592000													36	65					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594625	140594625	+	Silent	SNP	C	C	T	rs150808997		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140594625C>T	ENST00000341948.4	+	1	1117	c.930C>T	c.(928-930)ttC>ttT	p.F310F		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		310	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.F310F(2)		NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTCGATTTCGAAAAACTTC	0.378000													74	147					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15061170	15061170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15061170C>T	ENST00000430939.2	-	9	1469	c.1340G>A	c.(1339-1341)gGg>gAg	p.G447E	SLC1A6_ENST00000221742.3_Missense_Mutation_p.G511E|SLC1A6_ENST00000600144.1_Missense_Mutation_p.G433E			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	511					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	AATTGAGTCCCCCAGTACGTT	0.567000													21	51					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74347430	74347430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:74347430G>A	ENST00000377044.4	-	7	1939	c.1400C>T	c.(1399-1401)cCt>cTt	p.P467L	TMEM2_ENST00000377066.5_Missense_Mutation_p.P404L	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	467						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CAGGAACTGAGGGGTTTCTGG	0.408000													22	35					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2967321	2967321	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:2967321C>T	ENST00000397461.1	+	12	1600	c.1216C>T	c.(1216-1218)Cca>Tca	p.P406S	CNTN4_ENST00000418658.1_Missense_Mutation_p.P406S|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000448906.2_Missense_Mutation_p.P78S|CNTN4_ENST00000358480.3_Missense_Mutation_p.P187S|CNTN4_ENST00000397459.2_Missense_Mutation_p.P78S|CNTN4_ENST00000427331.1_Missense_Mutation_p.P406S	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	406	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGCTGTAGGTCCAGATTTTTC	0.358000													33	125					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2900696	2900696	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:2900696G>A	ENST00000380698.4	-	2	239	c.150C>T	c.(148-150)acC>acT	p.T50T		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	50					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TCTGGGTTGCGGTGTTTCCCT	0.582000													67	130					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43777460	43777460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43777460C>T	ENST00000389420.3	-	31	4697	c.4698G>A	c.(4696-4698)gtG>gtA	p.V1566V		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1566	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTATTTCATTCACTTGTCTGA	0.368000													11	44					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811088	23811088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23811088G>A	ENST00000314520.3	+	1	635	c.159G>A	c.(157-159)agG>agA	p.R53R	MKRN3_ENST00000564592.1_Silent_p.R53R|MKRN3_ENST00000568252.1_Silent_p.R53R	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	53						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		ATGCGGCAAGGGGCTGGGCCC	0.687000													13	55					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124915205	124915205	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124915205G>A	ENST00000356219.3	-	10	1166	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000405201.1_Silent_p.F337F|NCOR2_ENST00000404621.1_Silent_p.F337F|NCOR2_ENST00000429285.2_Silent_p.F337F|NCOR2_ENST00000397355.1_Silent_p.F337F	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	337					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGATCTCAGGGAACTGCTTCT	0.677000													38	118					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43197462	43197462	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:43197462G>A	ENST00000522175.2	+	0	1215							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACTCAAAATGGATTTTAACGG	0.373000													38	99					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19752519	19752519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:19752519C>T	ENST00000400113.3	-	3	346	c.242G>A	c.(241-243)gGa>gAa	p.G81E		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	81					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CCTATAGGTTCCTGTGCGCAC	0.488000													31	79					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70543268	70543268	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70543268G>A	ENST00000323786.5	-	7	889	c.868C>T	c.(868-870)Cac>Tac	p.H290Y	COG4_ENST00000393612.4_Missense_Mutation_p.H286Y	NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	286					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				ATTGGCTGGTGGGTCTCCACA	0.473000													18	60					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48908153	48908153	+	Missense_Mutation	SNP	G	G	T	rs77698773		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48908153G>T	ENST00000263269.3	+	3	716	c.628G>T	c.(628-630)Ggt>Tgt	p.G210C		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	210						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GCTGACTGACGGTAGTCTGGT	0.662000													36	165					3.33393e-15	3.35187e-15	1	1	0
SEC14L5	9717	broad.mit.edu	37	16	5047039	5047039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:5047039G>A	ENST00000251170.7	+	8	1144	c.964G>A	c.(964-966)Gac>Aac	p.D322N		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	322	CRAL-TRIO.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						GCATTACCAGGACATAGGTGC	0.532000													5	18					0	0	1	0	0
SEPT8	23176	broad.mit.edu	37	5	132100089	132100089	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132100089G>A	ENST00000296873.7	-	3	457	c.174C>T	c.(172-174)tcC>tcT	p.S58S	SEPT8_ENST00000378699.2_5'UTR|SEPT8_ENST00000378721.4_Silent_p.S58S|SEPT8_ENST00000378706.1_Silent_p.S58S|SEPT8_ENST00000378701.1_Silent_p.S58S|SEPT8_ENST00000458488.2_Silent_p.S58S|SEPT8_ENST00000378719.2_Silent_p.S58S|SEPT8_ENST00000448933.1_5'UTR	NM_001098812.1|NM_015146.1	NP_001092282.1|NP_055961.1	Q92599	SEPT8_HUMAN	septin 8	58					cell cycle	septin complex	GTP binding|protein binding		SEPT8/AFF4(2)	kidney(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCATCAGTGTGGATTTGCCAA	0.587000													11	34					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032486	142032486	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142032486G>A	ENST00000547918.2	+	0	339																											AGCGCACACAGCAGGGGGACT	0.557000													12	18					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22157780	22157780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22157780G>A	ENST00000374695.3	-	84	11569	c.11490C>T	c.(11488-11490)atC>atT	p.I3830I		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3830	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CATGGAAGACGATCTCCTCGC	0.677000													17	71					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41496622	41496622	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41496622G>A	ENST00000313860.7	+	2	220	c.167_splice	c.e2+1	p.E56_splice	LIMCH1_ENST00000509638.1_Intron|LIMCH1_ENST00000513024.1_5'UTR|LIMCH1_ENST00000508501.1_Splice_Site_p.E56_splice|LIMCH1_ENST00000512946.1_Splice_Site_p.E56_splice|LIMCH1_ENST00000512820.1_Splice_Site_p.E56_splice|LIMCH1_ENST00000512632.1_Splice_Site_p.E56_splice	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	56	CH.				actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						CCTCCTCTGCGAGTAAGTATA	0.328000													18	45					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186045650	186045650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186045650C>T	ENST00000271588.4	+	54	8610	c.8381C>T	c.(8380-8382)cCc>cTc	p.P2794L	HMCN1_ENST00000367492.2_Missense_Mutation_p.P2794L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2794	Ig-like C2-type 26.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATCAACAATCCCATTTCTCTT	0.433000													33	67					0	0	1	0	0
PPP1R3C	5507	broad.mit.edu	37	10	93390138	93390138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:93390138C>T	ENST00000238994.5	-	2	584	c.500G>A	c.(499-501)cGa>cAa	p.R167Q		NM_005398.5	NP_005389.1	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory subunit 3C	167	CBM21.|Interaction with EPM2A.						protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(1)	12		Colorectal(252;0.235)				TGTCACTGTTCGCTCTTGCAA	0.413000													41	117					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78369603	78369603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78369603G>A	ENST00000278550.7	-	34	8272	c.7810C>T	c.(7810-7812)Cta>Tta	p.L2604L		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AGGTTCTCTAGGTAGTGGGCA	0.542000													12	28					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234855777	234855777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234855777G>A	ENST00000324695.4	+	8	960	c.920G>A	c.(919-921)gGa>gAa	p.G307E	AC005538.5_ENST00000455991.1_RNA|TRPM8_ENST00000433712.2_5'UTR	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	307						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TTTGCCCAAGGAGGTGGAAAA	0.368000													21	50					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13052931	13052931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:13052931G>A	ENST00000399002.2	+	3	605	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K	SPTLC3_ENST00000378194.4_Missense_Mutation_p.E111K	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	111					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	TCAAGACTTTGAAAATTTTTA	0.428000													66	154					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207644767	207644767	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207644767G>A	ENST00000367057.3	+	9	1682		c.e9-1		CR2_ENST00000367059.3_Splice_Site|CR2_ENST00000458541.2_Intron|CR2_ENST00000367058.3_Splice_Site	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2						complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TCTGTCTCTAGGTACAAGTTA	0.438000													55	125					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347469	91347469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91347469C>T	ENST00000358859.2	-	1	1484	c.1051G>A	c.(1051-1053)Gag>Aag	p.E351K	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		CCTCTCTGCTCGTTCTCCTCC	0.488000													26	75					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142237983	142237983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:142237983C>T	ENST00000389484.3	-	3	1296	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	109	LDL-receptor class A 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTACTCCTTCGTCATACCCA	0.413000										TSP Lung(27;0.18)			12	54					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175467	159175467	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159175467C>T	ENST00000537147.1	+	3	1081	c.238C>T	c.(238-240)Ctc>Ttc	p.L80F	DARC_ENST00000368121.2_Missense_Mutation_p.L82F|DARC_ENST00000368122.2_Missense_Mutation_p.L80F			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	80					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					CAGCACTGTCCTCTTCATGCT	0.592000													15	173					0	0	1	0	0
GNG2	54331	broad.mit.edu	37	14	52433336	52433336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52433336C>T	ENST00000335281.4	+	3	553	c.147C>T	c.(145-147)ccC>ccT	p.P49P	GNG2_ENST00000553299.1_3'UTR|GNG2_ENST00000556752.1_Silent_p.P49P|GNG2_ENST00000553432.1_Silent_p.P80P|GNG2_ENST00000555472.1_Silent_p.P49P|GNG2_ENST00000557376.1_Silent_p.P88P|GNG2_ENST00000554736.1_Silent_p.P49P|GNG2_ENST00000556766.1_Silent_p.P49P	NM_001243774.1	NP_001230703.1	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein), gamma 2	49					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity			lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	5	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	AGGAAGACCCCCTCCTGACCC	0.522000													43	136					0	0	1	0	0
GAST	2520	broad.mit.edu	37	17	39872043	39872043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39872043G>A	ENST00000329402.3	+	3	292	c.225G>A	c.(223-225)aaG>aaA	p.K75K	JUP_ENST00000540235.1_Intron	NM_000805.4	NP_000796.1	P01350	GAST_HUMAN	gastrin	75		Cleavage.				extracellular region	hormone activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			CGTCCAAGAAGCAGGGACCAT	0.557000													38	50					0	0	1	0	0
ASAH2	56624	broad.mit.edu	37	10	52003004	52003004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52003004G>A	ENST00000395526.3	-	3	467	c.468C>T	c.(466-468)gtC>gtT	p.V156V	ASAH2_ENST00000329428.6_Silent_p.V137V|ASAH2_ENST00000447815.1_Silent_p.V156V	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	156					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(1)|lung(9)|urinary_tract(1)	11						TGTCGATGCTGACAAACACTG	0.473000													68	173					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50949255	50949255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50949255C>T	ENST00000357701.5	+	12	1303	c.1252C>T	c.(1252-1254)Cgc>Tgc	p.R418C		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	418	Ig-like C2-type 3.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GGACAGGGGTCGCTATCAGGT	0.597000													5	20					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004579	41004579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41004579G>A	ENST00000399564.4	-	37	4513	c.4063C>T	c.(4063-4065)Cac>Tac	p.H1355Y	MROH2B_ENST00000506092.2_Missense_Mutation_p.H910Y	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CGAGCTAGGTGATACAGGCCT	0.403000													28	64					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1407740	1407740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1407740C>T	ENST00000381524.3	+	6	618	c.432C>T	c.(430-432)gcC>gcT	p.A144A	CSF2RA_ENST00000381529.3_Silent_p.A144A|CSF2RA_ENST00000417535.2_Silent_p.A144A|CSF2RA_ENST00000501036.2_Silent_p.A11A|CSF2RA_ENST00000381509.3_Silent_p.A144A|CSF2RA_ENST00000381500.1_Silent_p.A144A|CSF2RA_ENST00000355432.3_Silent_p.A144A|CSF2RA_ENST00000361536.3_Silent_p.A144A|CSF2RA_ENST00000355805.2_Silent_p.A144A|CSF2RA_ENST00000432318.2_Silent_p.A144A			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	144						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GTCCGACGGCCCCCCGTGACG	0.473000													31	152					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904282	5904282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5904282G>A	ENST00000378961.4	+	4	1696	c.1492G>A	c.(1492-1494)Gaa>Aaa	p.E498K		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	498						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						AAACAGGGAGGAAGCTAGGTT	0.488000													28	62					0	0	1	0	0
HPCAL1	3241	broad.mit.edu	37	2	10560075	10560075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:10560075C>T	ENST00000381765.3	+	4	718	c.192C>T	c.(190-192)ttC>ttT	p.F64F	HPCAL1_ENST00000307845.3_Silent_p.F64F	NM_134421.2	NP_602293.1	P37235	HPCL1_HUMAN	hippocalcin-like 1	64	EF-hand 2.						calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	9	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		CTTCCAAGTTCGCCGAGCACG	0.617000													9	79					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73470747	73470747	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73470747C>T	ENST00000252034.7	+	20	1696	c.1297C>T	c.(1297-1299)Ccg>Tcg	p.P433S	ELN_ENST00000380553.4_Missense_Mutation_p.P316S|ELN_ENST00000380562.4_Missense_Mutation_p.P433S|ELN_ENST00000358929.4_Missense_Mutation_p.P433S|ELN_ENST00000414324.1_Missense_Mutation_p.P428S|ELN_ENST00000320399.6_Missense_Mutation_p.P433S|ELN_ENST00000429192.1_Missense_Mutation_p.P438S|ELN_ENST00000380584.4_Missense_Mutation_p.P419S|ELN_ENST00000445912.1_Missense_Mutation_p.P433S|ELN_ENST00000458204.1_Missense_Mutation_p.P423S|ELN_ENST00000357036.5_Missense_Mutation_p.P438S|ELN_ENST00000380576.5_Missense_Mutation_p.P433S|ELN_ENST00000320492.7_Intron|ELN_ENST00000380575.4_Missense_Mutation_p.P423S	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	433	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CGGAGGTGTCCCGGGAGTTGG	0.637000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						44	82					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762606	24762606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24762606G>A	ENST00000376451.2	+	2	710	c.450G>A	c.(448-450)gcG>gcA	p.A150A	KIAA1217_ENST00000307544.6_Silent_p.A150A|KIAA1217_ENST00000458595.1_Silent_p.A432A|KIAA1217_ENST00000396446.1_Silent_p.A150A|KIAA1217_ENST00000430453.2_Silent_p.A353A|KIAA1217_ENST00000376462.1_Silent_p.A352A|KIAA1217_ENST00000396445.1_Silent_p.A150A|KIAA1217_ENST00000376452.3_Silent_p.A432A|KIAA1217_ENST00000376454.3_Silent_p.A432A			Q5T5P2	SKT_HUMAN	KIAA1217	432					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TCCGGTCAGCGAGTGCTTATT	0.507000													22	69					0	0	1	0	0
ADAD2	161931	broad.mit.edu	37	16	84228059	84228059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84228059C>T	ENST00000268624.3	+	3	739	c.646C>T	c.(646-648)Ccc>Tcc	p.P216S	RP11-486L19.2_ENST00000536986.1_RNA|ADAD2_ENST00000315906.5_Missense_Mutation_p.P144S|RP11-486L19.2_ENST00000565643.1_RNA|RP11-486L19.2_ENST00000561900.1_RNA	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	144					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding	p.P216S(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						TCCCTGCTTCCCCTTCTCGGT	0.642000													7	11					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71797676	71797676	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:71797676G>A	ENST00000269500.5	-	4	657	c.322C>T	c.(322-324)Cca>Tca	p.P108S	FBXO15_ENST00000419743.2_Missense_Mutation_p.P184S	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	108										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		GTCTTAACTGGAAGGCCTGTG	0.433000													20	59					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77910348	77910348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77910348C>T	ENST00000302536.2	+	5	957	c.804C>T	c.(802-804)ccC>ccT	p.P268P	VAT1L_ENST00000563850.1_3'UTR	NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	268							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						TTCTCAAACCCCTGGGAACCT	0.473000													23	109					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652070	121652070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121652070C>T	ENST00000393386.2	+	12	3381	c.2970C>T	c.(2968-2970)ctC>ctT	p.L990L	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	990					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CTCATGCCCTCTCTGGTGATG	0.458000													59	129					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277055	114277055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114277055C>T	ENST00000357077.4	+	38	7334	c.7281C>T	c.(7279-7281)gaC>gaT	p.D2427D	ANK2_ENST00000264366.6_Silent_p.D2394D|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2394					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGGCTGATGACTCATTAGCAG	0.502000													24	48					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196786849	196786849	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196786849T>C	ENST00000312428.6	-	24	3998	c.3898A>G	c.(3898-3900)Agg>Ggg	p.R1300G		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1300	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATAACCAGCCTAGGGGAATTA	0.343000													20	44					0	0	1	0	0
RGAG4	340526	broad.mit.edu	37	X	71349761	71349761	+	Nonsense_Mutation	SNP	G	G	A	rs12401231		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:71349761G>A	ENST00000545866.1	-	1	1997	c.1630C>T	c.(1630-1632)Cga>Tga	p.R544*	NHSL2_ENST00000540800.1_Intron|RGAG4_ENST00000479991.1_Nonsense_Mutation_p.R544*			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	544										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					GGGCGTCTTCGAACTTGGCGT	0.602000													7	20					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55445082	55445082	+	Missense_Mutation	SNP	C	C	T	rs142522707	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55445082C>T	ENST00000446217.1	-	10	2983	c.2581G>A	c.(2581-2583)Gcc>Acc	p.A861T	NLRP7_ENST00000592784.1_Missense_Mutation_p.A833T|NLRP7_ENST00000340844.2_Missense_Mutation_p.A833T|NLRP7_ENST00000588756.1_Missense_Mutation_p.A833T|NLRP7_ENST00000448121.2_Missense_Mutation_p.A805T|NLRP7_ENST00000328092.5_Missense_Mutation_p.A805T|NLRP7_ENST00000590030.1_Missense_Mutation_p.A833T			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	833							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TTGCAACTGGCTTCTGTAAGA	0.468000													22	86					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21318838	21318838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:21318838G>A	ENST00000583088.1	+	3	1079	c.184G>A	c.(184-186)Gag>Aag	p.E62K	KCNJ12_ENST00000331718.5_Missense_Mutation_p.E62K	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CAACATGGACGAGAAGTCACA	0.592000										Prostate(3;0.18)			13	41					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1321317	1321317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1321317G>A	ENST00000381567.3	-	4	437	c.438C>T	c.(436-438)ctC>ctT	p.L146L	CRLF2_ENST00000381566.1_Silent_p.L146L|CRLF2_ENST00000467626.1_5'UTR	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	146	Fibronectin type-III.					extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CCTCATAGAGGAGATCCCCGT	0.612000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								17	80					0	0	1	0	0
VSX2	338917	broad.mit.edu	37	14	74726416	74726416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74726416C>T	ENST00000261980.2	+	4	781	c.691C>T	c.(691-693)Ccc>Tcc	p.P231S		NM_182894.2	NP_878314.1	P58304	VSX2_HUMAN	visual system homeobox 2	231	CVC.				multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00154)		GCACTCCATCCCCCTGCCCGA	0.647000													21	62					0	0	1	0	0
RECK	8434	broad.mit.edu	37	9	36117063	36117063	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:36117063C>T	ENST00000377966.3	+	17	2708	c.2142C>T	c.(2140-2142)ctC>ctT	p.L714L		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	714	Kazal-like 2.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CAAGACAGCTCGCGTGTGACC	0.458000													21	64					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193166058	193166058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:193166058C>T	ENST00000342695.4	-	18	2411	c.2089G>A	c.(2089-2091)Gaa>Aaa	p.E697K	ATP13A4_ENST00000392443.3_Missense_Mutation_p.E678K	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	697					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TTTGTCTCTTCCTTCAATCGA	0.388000													33	45					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206050515	206050515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206050515C>T	ENST00000406610.2	+	14	2159	c.1952C>T	c.(1951-1953)gCc>gTc	p.A651V	PARD3B_ENST00000349953.3_Missense_Mutation_p.A651V|PARD3B_ENST00000351153.1_Missense_Mutation_p.A651V|PARD3B_ENST00000358768.2_Missense_Mutation_p.A589V|PARD3B_ENST00000462231.1_Missense_Mutation_p.A651V	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	651					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GACGGATGGGCCGAGAGTGAA	0.438000													40	94					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100841514	100841514	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:100841514C>T	ENST00000369208.3	-	11	2201	c.1419G>A	c.(1417-1419)gaG>gaA	p.E473E	SIM1_ENST00000262901.4_Silent_p.E473E			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	473	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		ACCTGCCTGCCTCACATCGGC	0.642000													9	73					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38968367	38968367	+	Silent	SNP	G	G	A	rs113831421		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38968367G>A	ENST00000355481.4	+	30	4442	c.4311G>A	c.(4309-4311)agG>agA	p.R1437R	RYR1_ENST00000360985.3_Silent_p.R1437R|RYR1_ENST00000359596.3_Silent_p.R1437R	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1437	6 X approximate repeats.|B30.2/SPRY 3.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACTCCGTGAGGGTCTTTGCTG	0.597000													11	45					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129875931	129875931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129875931C>T	ENST00000254667.3	+	19	2055	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F	PTPRE_ENST00000306042.5_Silent_p.F534F|PTPRE_ENST00000419012.2_Silent_p.F592F	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	592	Tyrosine-protein phosphatase 2.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				AGTTTCACTTCCACGGCTGGC	0.662000													7	47					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810368	123810368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123810368G>A	ENST00000307033.2	+	1	119	c.45G>A	c.(43-45)ctG>ctA	p.L15L		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTGTTCTACTGGGGCTCTCTC	0.418000													30	84					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87362036	87362036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87362036G>A	ENST00000327946.7	-	16	3109	c.3024C>T	c.(3022-3024)tcC>tcT	p.S1008S	GRID1_ENST00000552278.2_5'UTR|GRID1_ENST00000536331.1_Silent_p.S579S	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	1008						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GCAGTCAGATGGAGGTCCCGT	0.617000										Multiple Myeloma(13;0.14)			8	15					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96698548	96698548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96698548C>T	ENST00000260682.6	+	1	121	c.109C>T	c.(109-111)Cca>Tca	p.P37S	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	37					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	CACTCCTCTCCCAGTGATTGG	0.458000													47	129					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107266583	107266583	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107266583T>C	ENST00000334726.2	+	1	129	c.40T>C	c.(40-42)Ttc>Ctc	p.F14L		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						AGTATTTTTCTTCCTGGGATT	0.383000													10	70					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113464984	113464984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113464984C>T	ENST00000487903.1	+	5	473	c.385C>T	c.(385-387)Cct>Tct	p.P129S	ATP11A_ENST00000375645.3_Missense_Mutation_p.P129S|ATP11A_ENST00000283558.8_Missense_Mutation_p.P129S|ATP11A_ENST00000375630.2_Missense_Mutation_p.P129S			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	129					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GAACCAGTGTCCTGTTCATTT	0.473000													16	146					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4853129	4853129	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4853129G>A	ENST00000354582.6	+	55	7758	c.7408G>A	c.(7408-7410)Gaa>Aaa	p.E2470K	ITPR1_ENST00000463980.1_3'UTR|ITPR1_ENST00000302640.8_Missense_Mutation_p.E2470K|ITPR1_ENST00000456211.2_Missense_Mutation_p.E2422K|ITPR1_ENST00000423119.2_Missense_Mutation_p.E2437K|ITPR1_ENST00000544951.1_Missense_Mutation_p.E448K|ITPR1_ENST00000357086.4_Missense_Mutation_p.E2437K|ITPR1_ENST00000443694.2_Missense_Mutation_p.E2470K			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2485					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GCTGCCCAATGAAACAGCTGT	0.383000													27	81					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082505	9082505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9082505C>T	ENST00000397910.4	-	1	9513	c.9310G>A	c.(9310-9312)Gag>Aag	p.E3104K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3105	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGTTCCCTCTTCTTCTGCA	0.488000													82	212					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10155574	10155574	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10155574C>T	ENST00000343090.6	+	3	342	c.267C>T	c.(265-267)ccC>ccT	p.P89P	UBE4B_ENST00000253251.8_Silent_p.P89P|UBE4B_ENST00000377157.3_5'UTR	NM_001105562.2	NP_001099032.1	O95155	UBE4B_HUMAN	ubiquitination factor E4B	89					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GCAGCTCGCCCTCTAATAGCC	0.468000													8	101					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57132039	57132039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:57132039G>A	ENST00000296318.7	-	12	1780	c.1692C>T	c.(1690-1692)ttC>ttT	p.F564F	IL17RD_ENST00000320057.5_Silent_p.F420F|IL17RD_ENST00000463523.1_Silent_p.F420F|IL17RD_ENST00000427856.2_Silent_p.F540F	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	564						Golgi membrane|integral to membrane|plasma membrane	receptor activity	p.F420F(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		GGAAGGGAACGAACTGCTTTT	0.527000													10	42					0	0	1	0	0
HDGFRP3	50810	broad.mit.edu	37	15	83820065	83820065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83820065C>T	ENST00000299633.4	-	5	1111	c.508G>A	c.(508-510)Gac>Aac	p.D170N		NM_016073.3	NP_057157.1	Q9Y3E1	HDGR3_HUMAN		170					cell proliferation	nucleus	growth factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						TCTTTGCAGTCTTTGTCATCT	0.408000													16	133					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111156206	111156206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111156206C>T	ENST00000360467.5	+	44	4457	c.4151C>T	c.(4150-4152)aCt>aTt	p.T1384I	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1384	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GCCCCCGGGACTGTGGGAGCC	0.652000													20	73					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21876619	21876619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21876619G>A	ENST00000399982.2	-	12	2646	c.2582C>T	c.(2581-2583)cCc>cTc	p.P861L	CHD8_ENST00000557364.1_Missense_Mutation_p.P861L|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Missense_Mutation_p.P582L	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	861	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GACCAAGAAGGGACCATGGAT	0.468000													12	77					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69699102	69699102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69699102C>T	ENST00000194900.4	+	11	1903	c.1562C>T	c.(1561-1563)tCc>tTc	p.S521F	DLG3_ENST00000374360.3_Missense_Mutation_p.S503F|DLG3_ENST00000542398.1_Missense_Mutation_p.S20F|DLG3_ENST00000374355.3_Missense_Mutation_p.S166F			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	503	SH3.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					GAAAAGAGGTCCTTGTATGTC	0.493000													40	29					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158587369	158587369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158587369G>A	ENST00000368148.3	-	47	6738	c.6558C>T	c.(6556-6558)ctC>ctT	p.L2186L	SPTA1_ENST00000368147.3_Silent_p.L2183L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2186					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTGTTTCTTTGAGCAATGATC	0.343000													18	39					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884436	24884436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24884436C>T	ENST00000382554.3	+	9	3799	c.3481C>T	c.(3481-3483)Cgc>Tgc	p.R1161C		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1161					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GCTGCCCTTCCGCCTGGAGGT	0.647000													25	61					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83437738	83437738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83437738C>T	ENST00000334574.8	-	9	1628	c.1447G>A	c.(1447-1449)Gaa>Aaa	p.E483K	FSD2_ENST00000541889.1_Missense_Mutation_p.E438K			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	483	Fibronectin type-III 2.									breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						ACAGCCTCTTCACAGCTCCTT	0.493000													6	25					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111158873	111158873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111158873C>T	ENST00000360467.5	+	46	4820	c.4514C>T	c.(4513-4515)cCa>cTa	p.P1505L	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1505	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCCATGTGCCCAGTGGGCATG	0.652000													4	27					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921425	24921425	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24921425C>T	ENST00000329468.2	+	1	885	c.411C>T	c.(409-411)gcC>gcT	p.A137A		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CGGTCAAGGCCAGGAAGCCCA	0.622000													17	53					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940754	22940754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22940754C>T	ENST00000397104.3	-	5	1683	c.1684G>A	c.(1684-1686)Gaa>Aaa	p.E562K	ZNF99_ENST00000596209.1_Missense_Mutation_p.E653K					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTACCACATTCTTCACATTTG	0.383000													21	76					0	0	1	0	0
VDR	7421	broad.mit.edu	37	12	48240513	48240513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48240513G>A	ENST00000229022.3	-	9	1115	c.834C>T	c.(832-834)tcC>tcT	p.S278S	VDR_ENST00000535672.1_Silent_p.S246S|VDR_ENST00000550325.1_Silent_p.S328S|VDR_ENST00000395324.2_Silent_p.S278S|VDR_ENST00000549336.1_Silent_p.S278S	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	278	Ligand-binding.|Vitamin D3 binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CCATGGTGAAGGACTCATTGG	0.552000													27	67					0	0	1	0	0
ZIC3	7547	broad.mit.edu	37	X	136649320	136649320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:136649320C>T	ENST00000287538.5	+	1	1020	c.470C>T	c.(469-471)cCt>cTt	p.P157L	ZIC3_ENST00000370606.3_Missense_Mutation_p.P157L	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	157					cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					CCCGAGCCCCCTAGCTACTTG	0.711000													20	7					0	0	1	0	0
ZNF431	170959	broad.mit.edu	37	19	21366005	21366005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21366005C>T	ENST00000311048.7	+	5	1043	c.899C>T	c.(898-900)tCc>tTc	p.S300F	ZNF431_ENST00000594425.1_Intron|ZNF431_ENST00000600692.1_3'UTR	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						TTCAACCGGTCCTCACACCTT	0.398000													22	86					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3681616	3681616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:3681616C>T	ENST00000404826.2	+	4	731	c.592C>T	c.(592-594)Cag>Tag	p.Q198*	SDK1_ENST00000389531.3_Nonsense_Mutation_p.Q198*	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	198	Ig-like C2-type 2.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGATACGGACCAGAGGAAAAC	0.468000													13	66					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113935433	113935433	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:113935433A>T	ENST00000348367.4	-	6	535	c.338T>A	c.(337-339)cTt>cAt	p.L113H	GPAM_ENST00000369425.1_Missense_Mutation_p.L113H|GPAM_ENST00000423155.1_Missense_Mutation_p.L113H			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	113					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TTGAATAAAAAGAACGTAAGA	0.443000													40	89					0	0	1	0	0
EFS	10278	broad.mit.edu	37	14	23828896	23828896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23828896G>A	ENST00000216733.3	-	4	1398	c.791C>T	c.(790-792)cCt>cTt	p.P264L	EFS_ENST00000429593.2_Missense_Mutation_p.P95L|EFS_ENST00000351354.3_Missense_Mutation_p.P171L	NM_005864.2	NP_005855.1	O43281	EFS_HUMAN	embryonal Fyn-associated substrate	264	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)	16	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		CTCTGGAGAAGGGGGAGCCTC	0.672000													22	44					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68244848	68244848	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:68244848G>A	ENST00000347230.4	-	24	4930	c.4792C>T	c.(4792-4794)Ctg>Ttg	p.L1598L	ZFYVE26_ENST00000555452.1_Silent_p.L1598L	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1598					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTTACTTGCAGAGCCTTGTCA	0.433000													10	168					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143853238	143853238	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:143853238G>A	ENST00000507359.2	+	3	1939	c.848G>A	c.(847-849)tGg>tAg	p.W283*	KCTD16_ENST00000512467.1_Nonsense_Mutation_p.W283*	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16	283						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			CCTTCCAGATGGTCACCCTCA	0.507000													24	69					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1658192	1658192	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1658192G>A	ENST00000252804.4	-	15	1976	c.1926C>T	c.(1924-1926)acC>acT	p.T642T		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	642					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AATGTGTTCGGGTTGAGTTTA	0.468000													6	46					0	0	1	0	0
SEC1P	653677	broad.mit.edu	37	19	49183940	49183940	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49183940G>A	ENST00000430145.2	+	0	1027					NR_004401.2																						TACCTGCAGCGGGCCCTGGAC	0.692000													3	3					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117691445	117691445	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117691445C>T	ENST00000317775.6	-	17	3331	c.2646G>A	c.(2644-2646)gtG>gtA	p.V882V	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.V916V	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	882	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTGCTCACCTCACATTGGCCA	0.557000													23	78					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123494522	123494522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123494522G>A	ENST00000280562.5	-	5	723	c.518C>T	c.(517-519)tCc>tTc	p.S173F	PITPNM2_ENST00000320201.4_Missense_Mutation_p.S173F|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000546049.1_Missense_Mutation_p.S173F|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Missense_Mutation_p.S173F			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	173					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CCAGTTCTCGGACAGGGGCCC	0.552000													72	138					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35827133	35827133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35827133G>A	ENST00000085219.5	+	4	673	c.607G>A	c.(607-609)Gag>Aag	p.E203K	CD22_ENST00000419549.2_Missense_Mutation_p.E31K|CD22_ENST00000341773.6_Missense_Mutation_p.E203K|CD22_ENST00000536635.2_Missense_Mutation_p.E203K|CD22_ENST00000270311.6_Missense_Mutation_p.E83K|CD22_ENST00000544992.2_Missense_Mutation_p.E203K|CD22_ENST00000594250.1_Missense_Mutation_p.E203K	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	203	Ig-like C2-type 1.		E -> K.		cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CACCCGGAGCGAGCTCAAGTT	0.557000													30	64					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110864539	110864539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110864539C>T	ENST00000265171.5	+	3	902	c.457C>T	c.(457-459)Ctt>Ttt	p.L153F	EGF_ENST00000502723.1_3'UTR|EGF_ENST00000509793.1_Missense_Mutation_p.L153F|EGF_ENST00000503392.1_Missense_Mutation_p.L153F	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	153					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TTCCCACATTCTTTTAAGTGC	0.308000													20	84					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101493479	101493479	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101493479C>T	ENST00000392979.3	+	21	2386	c.2025C>T	c.(2023-2025)ttC>ttT	p.F675F	ANO4_ENST00000550015.1_Silent_p.F230F|ANO4_ENST00000392977.3_Silent_p.F710F|ANO4_ENST00000299222.9_Silent_p.F230F	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	710						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						ATGGACTCTTCGATGAATACT	0.333000										HNSCC(74;0.22)			49	28					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026768	79026768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79026768C>T	ENST00000446378.2	+	2	2211	c.2180C>T	c.(2179-2181)tCt>tTt	p.S727F		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	727						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAAGGTGTTTCTGAGTACATG	0.453000													30	60					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1953644	1953644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1953644G>A	ENST00000382722.5	-	25	2756	c.2394C>T	c.(2392-2394)ttC>ttT	p.F798F	CACNA2D4_ENST00000588077.1_Silent_p.F734F|CACNA2D4_ENST00000539048.2_5'UTR|CACNA2D4_ENST00000585708.1_Silent_p.F734F|CACNA2D4_ENST00000586184.1_Silent_p.F798F|CACNA2D4_ENST00000587995.1_Silent_p.F773F|CACNA2D4_ENST00000585732.1_Silent_p.F659F	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	798						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		ACCACAGCGGGAAGCGGTCCA	0.612000													13	24					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8808164	8808164	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8808164G>A	ENST00000447110.1	-	5	466	c.342C>T	c.(340-342)acC>acT	p.T114T	PIK3R5_ENST00000584803.1_Silent_p.T114T|PIK3R5_ENST00000581552.1_Silent_p.T114T	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	114					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						GAACAGGCCAGGTCAGGAACC	0.577000													13	52					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126132589	126132589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126132589C>T	ENST00000373631.3	+	7	1258	c.1257C>T	c.(1255-1257)gtC>gtT	p.V419V	CRB2_ENST00000359999.3_Silent_p.V419V|CRB2_ENST00000373629.2_Silent_p.V87V	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	419	EGF-like 9.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						AGTCTGGGGTCCACAGTTACG	0.622000													8	41					0	0	1	0	0
SHD	56961	broad.mit.edu	37	19	4283066	4283066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4283066G>A	ENST00000543264.2	+	3	1882	c.419G>A	c.(418-420)gGg>gAg	p.G140E	SHD_ENST00000599689.1_Missense_Mutation_p.G140E	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	140										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGGCAGAGGGGTGCAGCTC	0.612000													6	57					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43866259	43866259	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43866259G>A	ENST00000378009.4	+	0	1262				CTC-490G23.4_ENST00000607109.1_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CCACCAAAATGAGCATTCAGG	0.557000													7	88					0	0	1	0	0
GP6	51206	broad.mit.edu	37	19	55543725	55543725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55543725G>A	ENST00000310373.3	-	3	134	c.107C>T	c.(106-108)tCc>tTc	p.S36F	CTC-550B14.7_ENST00000586961.1_RNA|GP6_ENST00000333884.2_Missense_Mutation_p.S36F|CTC-550B14.6_ENST00000585492.1_RNA|CTC-550B14.7_ENST00000586845.1_RNA|CTC-550B14.7_ENST00000593060.1_RNA|GP6_ENST00000417454.1_Missense_Mutation_p.S36F	NM_001083899.1	NP_001077368.1	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	36	Ig-like C2-type 1.				enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		GGGCACCAGGGAGCTGGGCAG	0.697000													7	24					0	0	1	0	0
STAU2	27067	broad.mit.edu	37	8	74600939	74600939	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:74600939A>G	ENST00000355780.5	-	4	346	c.128T>C	c.(127-129)cTt>cCt	p.L43P	RP11-463D19.2_ENST00000358757.5_3'UTR|RP11-463D19.1_ENST00000533978.1_lincRNA|STAU2_ENST00000523558.1_Intron|STAU2_ENST00000524104.1_Missense_Mutation_p.L43P|STAU2_ENST00000517542.1_Missense_Mutation_p.L37P|STAU2_ENST00000521451.1_Intron|STAU2_ENST00000521727.1_Missense_Mutation_p.L55P|STAU2_ENST00000521210.1_Intron|STAU2_ENST00000521419.1_Missense_Mutation_p.L37P|STAU2_ENST00000522695.1_Missense_Mutation_p.L43P|STAU2_ENST00000522962.1_5'UTR|STAU2_ENST00000519961.1_Missense_Mutation_p.L75P|STAU2_ENST00000524300.1_Missense_Mutation_p.L75P|STAU2_ENST00000522509.1_Missense_Mutation_p.L43P	NM_014393.2	NP_055208.2	Q9NUL3	STAU2_HUMAN	staufen double-stranded RNA binding protein 2	75	DRBM 1.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)	19	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TGGTTTGGGAAGCGTAGATTC	0.463000													40	205					0	0	1	0	0
FOXJ1	2302	broad.mit.edu	37	17	74134103	74134103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74134103G>A	ENST00000322957.6	-	3	951	c.597C>T	c.(595-597)ccC>ccT	p.P199P		NM_001454.3	NP_001445.2	Q92949	FOXJ1_HUMAN	forkhead box J1	199					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|liver(1)|pancreas(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(166;0.187)			CCGCGTACTGGGGGTCAATGC	0.622000													14	25					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2820047	2820047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2820047G>A	ENST00000520002.1	-	62	10127	c.9572C>T	c.(9571-9573)tCc>tTc	p.S3191F	CSMD1_ENST00000542608.1_Missense_Mutation_p.S3013F|CSMD1_ENST00000537824.1_Missense_Mutation_p.S3190F|CSMD1_ENST00000602723.1_Missense_Mutation_p.S3014F|CSMD1_ENST00000400186.3_Missense_Mutation_p.S3014F|CSMD1_ENST00000602557.1_Missense_Mutation_p.S3191F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3191	Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCTTCTGGAGGATCCCACGAG	0.502000													10	30					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29295045	29295045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29295045C>T	ENST00000331664.5	-	1	2082	c.2083G>A	c.(2083-2085)Gaa>Aaa	p.E695K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	695					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TTGCCTTGTTCGTCCTCAGGA	0.537000													25	103					0	0	1	0	0
C3orf18	51161	broad.mit.edu	37	3	50602982	50602982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50602982G>A	ENST00000357203.3	-	3	688	c.149C>T	c.(148-150)cCt>cTt	p.P50L	C3orf18_ENST00000441239.1_Missense_Mutation_p.P50L|C3orf18_ENST00000426034.1_Missense_Mutation_p.P50L|C3orf18_ENST00000486175.1_Intron|C3orf18_ENST00000449241.1_Missense_Mutation_p.P50L	NM_016210.4	NP_057294.2	Q9UK00	CC018_HUMAN	chromosome 3 open reading frame 18	50						integral to membrane				lung(1)|pancreas(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.0175)|Kidney(197;0.0207)		AGCTGCATCAGGGATTCTGGT	0.607000													15	38					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13770902	13770902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13770902G>A	ENST00000265104.4	-	56	9665	c.9561C>T	c.(9559-9561)ttC>ttT	p.F3187F	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3187	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTCCATATATGAACTTATAGC	0.458000									Kartagener syndrome				28	61					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183696240	183696240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183696240G>A	ENST00000511685.1	+	24	5361	c.5238G>A	c.(5236-5238)ttG>ttA	p.L1746L	TENM3_ENST00000406950.2_Silent_p.L1746L					teneurin transmembrane protein 3																		GTCAAAACTTGGTGGAATGGA	0.522000													25	61					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144856938	144856938	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:144856938G>A	ENST00000369359.4	-	43	6993	c.6955C>T	c.(6955-6957)Cac>Tac	p.H2319Y	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.H2183Y|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.H2183Y|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.H2077Y|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.H2268Y			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2183					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCATCAATGTGGCCAATGACA	0.517000			T	PDGFRB	MPD								8	66					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	114141204	114141204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:114141204C>T	ENST00000371950.3	+	6	1232	c.508C>T	c.(508-510)Cgt>Tgt	p.R170C	HTR2C_ENST00000276198.1_Silent_p.F201F|HTR2C_ENST00000371951.1_Silent_p.F201F	NM_001256761.1	NP_001243690.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	0					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	AAAAGGTGTTCGTGAACAACA	0.448000													70	53					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92088158	92088158	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92088158C>T	ENST00000298047.6	+	1	2897	c.2880C>T	c.(2878-2880)acC>acT	p.T960T	FAT3_ENST00000541502.1_Silent_p.T960T|FAT3_ENST00000409404.2_Silent_p.T960T|FAT3_ENST00000525166.1_Silent_p.T810T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	960	Cadherin 9.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGCTTGAGACCCATGATCCAG	0.463000										TCGA Ovarian(4;0.039)			29	77					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39022673	39022673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39022673C>T	ENST00000379907.4	+	9	918	c.791C>T	c.(790-792)tCt>tTt	p.S264F	ADAM32_ENST00000437682.2_Missense_Mutation_p.S271F|ADAM32_ENST00000519315.1_Missense_Mutation_p.S264F	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	264	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGGAAACAATCTTATCTTAAC	0.308000													19	38					0	0	1	0	0
MMP24	10893	broad.mit.edu	37	20	33842389	33842389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33842389G>A	ENST00000246186.6	+	4	734	c.649G>A	c.(649-651)Gag>Aag	p.E217K	MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000433764.1_RNA|MMP24-AS1_ENST00000566203.1_RNA|EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000438751.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	217					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TGACCGGAAGGAGGCAGACAT	0.537000													63	230					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41021242	41021242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41021242G>A	ENST00000352632.3	+	15	2876	c.2790G>A	c.(2788-2790)atG>atA	p.M930I	SPTBN4_ENST00000344104.3_Missense_Mutation_p.M930I|SPTBN4_ENST00000595535.1_Missense_Mutation_p.M930I|SPTBN4_ENST00000598249.1_Missense_Mutation_p.M930I|SPTBN4_ENST00000338932.3_Missense_Mutation_p.M930I			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	930					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACCAAGAGATGAACAGCCTGA	0.562000													7	15					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32745514	32745514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32745514G>A	ENST00000333070.4	+	11	1304	c.1204G>A	c.(1204-1206)Gtg>Atg	p.V402M	LCK_ENST00000336890.5_Missense_Mutation_p.V372M|LCK_ENST00000373564.3_Missense_Mutation_p.V379M	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	372	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	CAACATTCTGGTGTCTGACAC	0.517000			T	TRB@	T-ALL								42	79					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594212	179594212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179594212C>T	ENST00000589042.1	-	64	18895	c.18671G>A	c.(18670-18672)gGa>gAa	p.G6224E	TTN_ENST00000342992.6_Missense_Mutation_p.G4980E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G5907E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5907	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGAGGTGTTCCCGTAACTTC	0.443000													27	104					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91348352	91348352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91348352G>A	ENST00000358859.2	-	1	601	c.168C>T	c.(166-168)ccC>ccT	p.P56P	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		ACTCGGTCTTGGGGCTATATC	0.642000													10	28					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153751848	153751848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153751848C>T	ENST00000271857.2	+	9	2918	c.2158C>T	c.(2158-2160)Cta>Tta	p.L720L	SLC27A3_ENST00000368661.3_Silent_p.L639L|SLC27A3_ENST00000484014.1_3'UTR			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	639					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AATGGCAGCCCTAGTTCTGCG	0.627000													31	80					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18889628	18889628	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18889628C>T	ENST00000380548.4	+	25	4864	c.4525C>T	c.(4525-4527)Cag>Tag	p.Q1509*	ADAMTSL1_ENST00000380545.5_Nonsense_Mutation_p.Q210*	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1509						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCGGGGGGTTCAGCAGCCCCG	0.607000													5	31					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11725780	11725780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11725780G>A	ENST00000262442.3	+	47	8944	c.8876G>A	c.(8875-8877)gGa>gAa	p.G2959E	DNAH9_ENST00000454412.2_Missense_Mutation_p.G2959E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2959	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCCCCTGTGGGAAACAAGCTA	0.542000													13	89					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166183422	166183422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166183422G>A	ENST00000375437.2	+	13	2367	c.2077G>A	c.(2077-2079)Gat>Aat	p.D693N	SCN2A_ENST00000375427.2_Missense_Mutation_p.D693N|SCN2A_ENST00000357398.3_Missense_Mutation_p.D693N|SCN2A_ENST00000283256.6_Missense_Mutation_p.D693N	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	693					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TGTTTCCATGGATTTATTGGA	0.373000													13	136					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173556803	173556803	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173556803C>T	ENST00000367714.3	-	5	946		c.e5+1		SLC9C2_ENST00000536496.1_Splice_Site|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)						sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										ATGTGACATACCAATAGTTTT	0.318000													24	59					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167170	140167170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140167170C>T	ENST00000504120.2	+	1	1295	c.1295C>T	c.(1294-1296)tCg>tTg	p.S432L	PCDHA1_ENST00000378133.3_Missense_Mutation_p.S432L|PCDHA1_ENST00000394633.3_Missense_Mutation_p.S432L	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGGGGGCTCGCCTTCGCTG	0.632000													55	151					0	0	1	0	0
DRAXIN	374946	broad.mit.edu	37	1	11766354	11766354	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11766354C>T	ENST00000294485.5	+	2	174	c.39C>T	c.(37-39)ttC>ttT	p.F13F		NM_198545.3	NP_940947.3			dorsal inhibitory axon guidance protein																		CCATGCTGTTCCTCGTCCTCC	0.652000													10	22					0	0	1	0	0
DPPA3	359787	broad.mit.edu	37	12	7864234	7864234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7864234C>T	ENST00000345088.2	+	1	185	c.68C>T	c.(67-69)tCc>tTc	p.S23F		NM_199286.2	NP_954980.1	Q6W0C5	DPPA3_HUMAN	developmental pluripotency associated 3	23						cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)	8				Kidney(36;0.0887)		GAAGAAAATTCCCGGGACGAT	0.468000													19	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069056	9069056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9069056G>A	ENST00000397910.4	-	3	18593	c.18390C>T	c.(18388-18390)tcC>tcT	p.S6130S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6132	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAATGTCTGGGGACTTTGTTG	0.507000													6	29					0	0	1	0	0
COBLL1	22837	broad.mit.edu	37	2	165559709	165559709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165559709G>A	ENST00000342193.4	-	9	1462	c.1247C>T	c.(1246-1248)tCc>tTc	p.S416F	COBLL1_ENST00000491126.2_Intron|COBLL1_ENST00000392717.2_Missense_Mutation_p.S454F|COBLL1_ENST00000409184.3_Intron|COBLL1_ENST00000375458.2_Intron|COBLL1_ENST00000194871.6_Missense_Mutation_p.S482F	NM_014900.3	NP_055715.3	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	454										central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						CTCCTGACTGGAAAGCCCAGG	0.488000													13	121					0	0	1	0	0
CEP70	80321	broad.mit.edu	37	3	138219681	138219681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:138219681G>A	ENST00000264982.3	-	14	1530	c.1264C>T	c.(1264-1266)Cct>Tct	p.P422S	CEP70_ENST00000542237.1_Missense_Mutation_p.P402S|CEP70_ENST00000481834.1_Missense_Mutation_p.P422S|CEP70_ENST00000484888.1_Missense_Mutation_p.P422S|CEP70_ENST00000489254.1_Missense_Mutation_p.P270S	NM_024491.2	NP_077817.2	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70kDa	422					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	24						TTAAGCCAAGGTACCAGTTCT	0.289000													18	88					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600269	29600269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29600269G>A	ENST00000431530.3	+	1	1522	c.1464G>A	c.(1462-1464)gaG>gaA	p.E488E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	478						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CTGTTGGAGAGAACAAGACGG	0.527000													17	52					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50964978	50964978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50964978G>A	ENST00000374103.4	-	3	304	c.219C>T	c.(217-219)ttC>ttT	p.F73F	OGDHL_ENST00000419399.1_Intron|OGDHL_ENST00000432695.1_Intron	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	73					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CTTCCCTGAAGAAGCTGTCCC	0.612000													17	61					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43753352	43753352	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:43753352T>G	ENST00000458276.2	+	4	781	c.658T>G	c.(658-660)Ttt>Gtt	p.F220V		NM_016006.4	NP_057090.2	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	220					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			kidney(3)|large_intestine(2)|liver(2)|lung(5)|ovary(1)|skin(1)	14		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		TGCAGGACCCTTTGGTGAGTG	0.403000													52	113					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210856647	210856647	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210856647C>T	ENST00000367007.4	-	11	3034	c.2865G>A	c.(2863-2865)gaG>gaA	p.E955E	KCNH1_ENST00000271751.4_Silent_p.E982E	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	982	CAD (involved in subunit assembly) (By similarity).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AAATGTCTCTCTCTGATTCTG	0.463000													16	241					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79365015	79365015	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79365015G>A	ENST00000444841.1	-	0	166																											TTTCTCAAGTGAACTCATATG	0.458000													3	5					0	0	1	0	0
HEYL	26508	broad.mit.edu	37	1	40092724	40092724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40092724G>A	ENST00000372852.3	-	5	761	c.442C>T	c.(442-444)Cgc>Tgc	p.R148C	HEYL_ENST00000535435.1_Missense_Mutation_p.R120C	NM_014571.3	NP_055386.1	Q9NQ87	HEYL_HUMAN	hes-related family bHLH transcription factor with YRPW motif-like	148	Orange.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAGAGAAGGCGAATCCGGACG	0.627000													18	48					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083611	9083611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9083611G>A	ENST00000397910.4	-	1	8407	c.8204C>T	c.(8203-8205)cCa>cTa	p.P2735L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2735	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTATTCCGTGGAGCAACAAT	0.463000													37	84					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129915067	129915067	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129915067G>A	ENST00000222481.4	+	6	620	c.565G>A	c.(565-567)Gca>Aca	p.A189T		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	189					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					ACAAGCTACGGCACTTTGGAC	0.502000													11	45					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242082349	242082349	+	Silent	SNP	G	G	A	rs145347607		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242082349G>A	ENST00000403638.3	-	2	190	c.99C>T	c.(97-99)acC>acT	p.T33T	PASK_ENST00000358649.4_Silent_p.T33T|PASK_ENST00000539818.1_Intron|PASK_ENST00000405260.1_Silent_p.T33T|PASK_ENST00000544142.1_5'UTR|PASK_ENST00000234040.4_Silent_p.T33T	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	33					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCTCAGCAGTGGTCTGTGCAG	0.597000													7	52					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154306661	154306661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154306661C>T	ENST00000368489.3	+	10	767	c.767C>T	c.(766-768)cCt>cTt	p.P256L	ATP8B2_ENST00000426445.1_3'UTR|ATP8B2_ENST00000368487.3_Missense_Mutation_p.P223L|ATP8B2_ENST00000341822.2_Missense_Mutation_p.P242L	NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	242					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AATAAGTTCCCTCTGAGCAAC	0.517000													30	327					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126705672	126705672	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:126705672G>A	ENST00000274473.6	+	6	657	c.390G>A	c.(388-390)tgG>tgA	p.W130*	MEGF10_ENST00000418761.2_Nonsense_Mutation_p.W130*|MEGF10_ENST00000503335.2_Nonsense_Mutation_p.W130*|MEGF10_ENST00000508365.1_Nonsense_Mutation_p.W130*	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	130	EGF-like 1.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGCCTGGCTGGGGAGGGACCA	0.507000													9	61					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33466326	33466326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33466326G>A	ENST00000379471.2	-	17	2276	c.2189C>T	c.(2188-2190)gCc>gTc	p.A730V	NOL6_ENST00000455041.2_Missense_Mutation_p.A678V|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	730					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CTCCACGTAGGCCGGACAGGG	0.612000											OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	97					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369669	56369669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56369669G>A	ENST00000301295.6	+	3	1332	c.910G>A	c.(910-912)Gag>Aag	p.E304K	NLRP4_ENST00000346986.5_Missense_Mutation_p.E304K|NLRP4_ENST00000587891.1_Missense_Mutation_p.E229K	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	304	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGGATTCAACGAGAGTGATAG	0.507000													25	63					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75900467	75900467	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:75900467G>A	ENST00000377636.3	-	10	2245	c.1899C>T	c.(1897-1899)tcC>tcT	p.S633S	TBC1D4_ENST00000377625.2_Silent_p.S633S|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000431480.2_Silent_p.S633S	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	633						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GAAACTGCGGGGAGTCGGAAT	0.582000													16	44					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40208396	40208396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:40208396G>A	ENST00000302541.6	+	6	952	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	MYRIP_ENST00000539167.1_Missense_Mutation_p.E17K|MYRIP_ENST00000444716.1_Missense_Mutation_p.E204K|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Missense_Mutation_p.E115K|MYRIP_ENST00000425621.1_Missense_Mutation_p.E204K	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	204	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GGCCATTGAGGAAGCAATTTC	0.552000													27	70					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450703	55450703	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55450703C>T	ENST00000446217.1	-	6	1970	c.1568G>A	c.(1567-1569)tGg>tAg	p.W523*	NLRP7_ENST00000592784.1_Nonsense_Mutation_p.W495*|NLRP7_ENST00000340844.2_Nonsense_Mutation_p.W495*|NLRP7_ENST00000588756.1_Nonsense_Mutation_p.W495*|NLRP7_ENST00000448121.2_Nonsense_Mutation_p.W495*|NLRP7_ENST00000328092.5_Nonsense_Mutation_p.W495*|NLRP7_ENST00000590030.1_Nonsense_Mutation_p.W495*			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	495							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CCCGATGTCCCAGGCGTGGCC	0.572000													7	96					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26343785	26343785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26343785C>T	ENST00000335473.7	+	36	5989	c.5739C>T	c.(5737-5739)ctC>ctT	p.L1913L	MYO18B_ENST00000536101.1_Silent_p.L1913L|MYO18B_ENST00000407587.2_Silent_p.L1914L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1913	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						ACAAGGACCTCATTGCTCAGG	0.537000													10	30					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70841825	70841825	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70841825G>A	ENST00000393567.2	-	86	15174	c.15024C>T	c.(15022-15024)ctC>ctT	p.L5008L		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	5008										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CTCCACCTGCGAGCGATGATA	0.587000													16	76					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707809	50707809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50707809C>T	ENST00000330943.4	-	4	630	c.459G>A	c.(457-459)atG>atA	p.M153I	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	153	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						GCTCACAGATCATCTCCTCAG	0.632000													10	31					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144917573	144917573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:144917573G>A	ENST00000529945.1	-	8	2459	c.2020C>T	c.(2020-2022)Ctt>Ttt	p.L674F	PDE4DIP_ENST00000369359.4_Missense_Mutation_p.L648F|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.L511F|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.L511F|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.L511F|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.L577F|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.L511F|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.L674F|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.L298F|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.L648F			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	511					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTCACAGCAAGACGAAGCTGG	0.448000			T	PDGFRB	MPD								19	491					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128509	152128509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152128509C>T	ENST00000316073.3	-	3	1130	c.1066G>A	c.(1066-1068)Gat>Aat	p.D356N		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	356	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding	p.D356N(1)		breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TTTGTCTGATCATAATGATAA	0.488000													323	732					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90020763	90020763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90020763C>T	ENST00000405460.2	+	46	9959	c.9863C>T	c.(9862-9864)tCt>tTt	p.S3288F		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3288					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGAAAATCATCTGTTACTGTT	0.294000													18	45					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145094856	145094856	+	Silent	SNP	C	C	T	rs60729674	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145094856C>T	ENST00000377470.3	+	2	360	c.258C>T	c.(256-258)ctC>ctT	p.L86L	SPATC1_ENST00000447830.2_Silent_p.L86L	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	86										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AACGAGTCCTCGAAGAAGTGG	0.642000													26	84					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39788323	39788323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:39788323C>T	ENST00000564288.1	+	32	4850	c.4073C>T	c.(4072-4074)tCg>tTg	p.S1358L	MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000567887.1_Missense_Mutation_p.S1395L|MACF1_ENST00000361689.2_Missense_Mutation_p.S1363L|MACF1_ENST00000539005.1_Missense_Mutation_p.S1363L|MACF1_ENST00000372915.3_Missense_Mutation_p.S1363L|MACF1_ENST00000317713.7_Missense_Mutation_p.S1363L|MACF1_ENST00000545844.1_Missense_Mutation_p.S1363L			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	1363					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding	p.S1363L(1)		breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTGTGGAATCGCAGCAGAAA	0.463000													39	97					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49674630	49674630	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49674630C>T	ENST00000252826.5	+	7	939	c.813C>T	c.(811-813)atC>atT	p.I271I	TRPM4_ENST00000427978.2_Silent_p.I271I|TRPM4_ENST00000601347.1_3'UTR|TRPM4_ENST00000355712.5_5'UTR	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	271					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GAATTGACATCCCTGTCCTGC	0.562000													15	59					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160808825	160808825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160808825G>A	ENST00000368034.4	-	4	847	c.670C>T	c.(670-672)Ccg>Tcg	p.P224S	CD244_ENST00000481677.1_5'UTR|CD244_ENST00000322302.7_Missense_Mutation_p.P132S|CD244_ENST00000368033.3_Missense_Mutation_p.P229S|CD244_ENST00000368032.2_Missense_Mutation_p.P224S	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	229					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACCAAAAACGGCCAAAATCTG	0.522000													19	51					0	0	1	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187694567	187694567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:187694567G>A	ENST00000295131.2	-	8	1021	c.982C>T	c.(982-984)Ctc>Ttc	p.L328F		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	328					apoptosis		zinc ion binding	p.L328I(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ATCAGTTGGAGAGGCAGTGAT	0.393000													34	133					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119966478	119966478	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119966478C>T	ENST00000327554.2	+	12	1753	c.1288C>T	c.(1288-1290)Caa>Taa	p.Q430*	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	430										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CTCAAATTTTCAAAAGGACAT	0.398000													52	112					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89854527	89854527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:89854527C>T	ENST00000287908.3	+	2	524	c.131C>T	c.(130-132)tCc>tTc	p.S44F	STEAP2_ENST00000394621.2_Missense_Mutation_p.S44F|STEAP2_ENST00000394622.2_Missense_Mutation_p.S44F|STEAP2_ENST00000394626.1_Missense_Mutation_p.S44F|STEAP2_ENST00000394632.1_Missense_Mutation_p.S44F|STEAP2_ENST00000402625.2_Missense_Mutation_p.S44F|STEAP2_ENST00000394629.2_Missense_Mutation_p.S44F	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	44					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					TTTGCCAAATCCTTGACCATT	0.388000													44	93					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35771777	35771777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35771777G>A	ENST00000440995.2	+	27	3853	c.3853G>A	c.(3853-3855)Gaa>Aaa	p.E1285K	SPEF2_ENST00000356031.3_Missense_Mutation_p.E1290K|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1290					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGACCCCAAAGAAAAATCTCC	0.398000													20	31					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73680076	73680076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73680076C>T	ENST00000264448.6	+	8	6530	c.6419C>T	c.(6418-6420)tCc>tTc	p.S2140F	ALMS1_ENST00000409009.1_Missense_Mutation_p.S2098F|ALMS1_ENST00000377715.1_Missense_Mutation_p.S2140F	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2140	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CTTCCTAGTTCCTTTTCACAT	0.413000													16	80					0	0	1	0	0
CD8B	926	broad.mit.edu	37	2	87085384	87085384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:87085384G>A	ENST00000390655.6	-	2	257	c.199C>T	c.(199-201)Cac>Tac	p.H67Y	CD8B_ENST00000349455.3_Missense_Mutation_p.H67Y|CD8B_ENST00000431506.2_Intron|CD8B_ENST00000393759.2_Missense_Mutation_p.H67Y|CD8B_ENST00000393761.2_Missense_Mutation_p.H67Y|CD8B_ENST00000331469.2_Missense_Mutation_p.H67Y	NM_004931.4	NP_004922.1	P10966	CD8B_HUMAN	CD8b molecule	67	Ig-like V-type.				immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	13						AGGAACTCGTGGTGACTGTCA	0.547000													7	89					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136597593	136597593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136597593G>A	ENST00000371872.4	-	3	719	c.462C>T	c.(460-462)ttC>ttT	p.F154F	SARDH_ENST00000298628.5_Silent_p.F154F|SARDH_ENST00000439388.1_Silent_p.F154F|SARDH_ENST00000371867.1_Silent_p.F65F|SARDH_ENST00000422262.2_5'UTR	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	154					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGGACGCGATGAAGAGGCCCC	0.672000													66	129					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20736568	20736568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20736568C>T	ENST00000427401.4	-	2	171	c.77G>A	c.(76-78)cGg>cAg	p.R26Q	ZNF737_ENST00000596797.1_Missense_Mutation_p.R26Q	NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	26					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						ATATAAATTCCGCTGTGCAGT	0.393000													19	225					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76450701	76450701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76450701G>A	ENST00000389840.5	-	64	10339	c.10215C>T	c.(10213-10215)ctC>ctT	p.L3405L	DNAH17_ENST00000585328.1_Silent_p.L3414L|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGTCGCTGGGGAGGCCCTGGT	0.642000													25	43					0	0	1	0	0
UBXN10	127733	broad.mit.edu	37	1	20517739	20517739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20517739G>A	ENST00000375099.3	+	2	769	c.685G>A	c.(685-687)Gaa>Aaa	p.E229K		NM_152376.3	NP_689589.1	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	229	UBX.									endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|skin(2)	14						TGCTGTGGCCGAACAGAAAAA	0.488000													38	76					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48866231	48866231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:48866231G>A	ENST00000314191.2	-	7	726	c.670C>T	c.(670-672)Ctg>Ttg	p.L224L	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Silent_p.L224L	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	224					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AACCCCTTCAGACATCCTGCC	0.388000								Non-homologous end-joining					6	20					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	141888927	141888927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141888927G>A	ENST00000306799.3	-	2	1238	c.585C>T	c.(583-585)atC>atT	p.I195I	RNF150_ENST00000507500.1_Silent_p.I195I|RNF150_ENST00000379512.2_Silent_p.I54I|RNF150_ENST00000515673.1_Silent_p.I195I|RNF150_ENST00000515057.1_5'UTR|RNF150_ENST00000420921.2_Silent_p.I54I	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150	195						integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					TCCGGGTTCCGATGGTGATGT	0.478000													55	162					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67664986	67664986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:67664986C>T	ENST00000335894.4	+	9	1357	c.1291C>T	c.(1291-1293)Cgc>Tgc	p.R431C	IQCH_ENST00000360277.4_Missense_Mutation_p.R183C|IQCH_ENST00000546225.1_Missense_Mutation_p.R179C|IQCH_ENST00000358767.3_Missense_Mutation_p.R258C	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	431										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		GGAGAATTTTCGCATTCGAGC	0.443000													52	174					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154667811	154667811	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:154667811G>A	ENST00000404039.1	+	20	2473		c.e20+1		DPP6_ENST00000332007.3_Splice_Site|DPP6_ENST00000427557.1_Splice_Site|DPP6_ENST00000377770.3_Splice_Site	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6						cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGGCCGTGCGGTGAGCACCCG	0.677000													4	18					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72993643	72993643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72993643G>A	ENST00000268489.5	-	2	1074	c.402C>T	c.(400-402)gtC>gtT	p.V134V	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	134					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CCGGCTGGTAGACGATCTCCC	0.711000													15	50					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356895	42356895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:42356895C>T	ENST00000554171.1	+	5	3499	c.1067C>T	c.(1066-1068)aCc>aTc	p.T356I	LRFN5_ENST00000298119.4_Missense_Mutation_p.T356I|LRFN5_ENST00000554120.1_Missense_Mutation_p.T356I			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	356	Ig-like.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GGTGCTTTTACCTGCATTGCT	0.393000										HNSCC(30;0.082)			43	91					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12649361	12649361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12649361C>T	ENST00000425538.1	+	9	1297	c.1097C>T	c.(1096-1098)cCa>cTa	p.P366L	MYOCD_ENST00000395988.1_Missense_Mutation_p.P270L|MYOCD_ENST00000343344.4_Missense_Mutation_p.P366L	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	366					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AAACCAGGCCCACTCCCACCT	0.408000													14	109					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158614085	158614085	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158614085C>T	ENST00000368148.3	-	30	4476	c.4296G>A	c.(4294-4296)ttG>ttA	p.L1432L	SPTA1_ENST00000368147.3_Silent_p.L1432L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1432					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTTCTTCATCAAAGCCTCCA	0.413000													31	64					0	0	1	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	521377	521377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:521377C>T	ENST00000262305.4	+	3	1279	c.891C>T	c.(889-891)ttC>ttT	p.F297F	RAB11FIP3_ENST00000457159.1_Silent_p.F297F	NM_014700.3	NP_055515.1	O75154	RFIP3_HUMAN	RAB11 family interacting protein 3 (class II)	297					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				TCGATGACTTCGTCACCTATG	0.602000													6	9					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149509362	149509362	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149509362G>A	ENST00000378016.2	+	0	9760							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGGAGCTGGGGGATGGGGTCC	0.701000													4	22					0	0	1	0	0
GADL1	339896	broad.mit.edu	37	3	30827849	30827849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:30827849C>T	ENST00000282538.5	-	13	1450	c.1300G>A	c.(1300-1302)Gaa>Aaa	p.E434K		NM_207359.2	NP_997242.2	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	434					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding			breast(2)|endometrium(3)|kidney(2)|lung(17)|upper_aerodigestive_tract(1)	25					Pyridoxal Phosphate(DB00114)	TCACTTACTTCCATCAGTAAC	0.299000													25	47					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47400205	47400205	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47400205G>A	ENST00000310638.4	-	7	848	c.817C>T	c.(817-819)Caa>Taa	p.Q273*	CYP4A11_ENST00000371904.4_Nonsense_Mutation_p.Q274*|CYP4A11_ENST00000457840.2_Missense_Mutation_p.S117L|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371905.1_Nonsense_Mutation_p.Q273*	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	273					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	TTCTGTAGTTGAGCCTTCCTC	0.532000													31	93					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28667647	28667647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28667647C>T	ENST00000280904.6	-	6	1203	c.760G>A	c.(760-762)Gaa>Aaa	p.E254K	DSC2_ENST00000251081.6_Missense_Mutation_p.E254K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	254	Cadherin 2.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CTGCAATTTTCAAAAATTGTA	0.333000													39	78					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154072474	154072474	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154072474C>T	ENST00000368559.3	-	14	2036	c.1965_splice	c.e14+1	p.K655_splice	NUP210L_ENST00000271854.3_Splice_Site_p.K655_splice	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	655						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AATATCTTACCTTTAGGGGTT	0.408000													78	188					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679883	100679883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100679883C>T	ENST00000306151.4	+	3	5250	c.5186C>T	c.(5185-5187)tCa>tTa	p.S1729L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1729	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCCGTTCATCTCCTACA	0.507000													159	451					0	0	1	0	0
LYSMD1	388695	broad.mit.edu	37	1	151134286	151134286	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151134286G>A	ENST00000368908.5	-	2	1131	c.471C>T	c.(469-471)ttC>ttT	p.F157F	LYSMD1_ENST00000440902.2_Silent_p.F109F	NM_212551.4	NP_997716.1	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain containing 1	157					cell wall macromolecule catabolic process					endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCTTCTTAAGGAAATCAGAGG	0.507000													60	106					0	0	1	0	0
CER1	9350	broad.mit.edu	37	9	14722227	14722227	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14722227G>A	ENST00000380911.3	-	1	488	c.444C>T	c.(442-444)gtC>gtT	p.V148V		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	148					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		TGGGCAAGATGACCCCCTGAG	0.493000													9	79					0	0	1	0	0
SMIM8	57150	broad.mit.edu	37	6	88046769	88046769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88046769C>T	ENST00000392863.1	+	3	109	c.20C>T	c.(19-21)cCt>cTt	p.P7L	SMIM8_ENST00000229570.5_Missense_Mutation_p.P7L	NM_001042493.1	NP_001035958.1			small integral membrane protein 8																		GCACCTGAGCCTCCAACATTC	0.383000													16	66					0	0	1	0	0
EXO5	64789	broad.mit.edu	37	1	40980428	40980428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40980428C>T	ENST00000372703.1	+	2	1286	c.212C>T	c.(211-213)tCa>tTa	p.S71L	EXO5_ENST00000358527.2_Missense_Mutation_p.S71L|EXO5_ENST00000296380.4_Missense_Mutation_p.S71L|RP11-656D10.5_ENST00000453437.1_RNA					exonuclease 5																		GATATATTATCACCCATGGAG	0.428000													41	147					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49420128	49420128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49420128G>A	ENST00000374201.3	-	13	1782	c.1480C>T	c.(1480-1482)Cac>Tac	p.H494Y	FRMPD2_ENST00000407470.4_Missense_Mutation_p.H462Y|FRMPD2_ENST00000305531.3_Missense_Mutation_p.H469Y	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	494	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		TCTTCAACGTGAAAGTATGGC	0.517000													12	22					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085734	9085734	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9085734G>A	ENST00000397910.4	-	1	6284	c.6081C>T	c.(6079-6081)tcC>tcT	p.S2027S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2027	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AATATGGAGAGGATGTGCTGC	0.483000													17	71					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075287	9075287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9075287G>A	ENST00000397910.4	-	3	12362	c.12159C>T	c.(12157-12159)tcC>tcT	p.S4053S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4055	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCTCTTAGAGGAGGTAATTT	0.502000													42	144					0	0	1	0	0
CCDC64B	146439	broad.mit.edu	37	16	3080783	3080783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3080783C>T	ENST00000572449.1	-	4	591	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K	CCDC64B_ENST00000573514.1_5'UTR|CCDC64B_ENST00000389347.4_Missense_Mutation_p.E177K			A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	177										breast(1)|endometrium(2)|large_intestine(1)	4						GCGTCCAGTTCCCTCTGAAGT	0.642000													4	12					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188190	152188190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152188190C>T	ENST00000368801.2	-	3	5990	c.5915G>A	c.(5914-5916)gGg>gAg	p.G1972E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1972					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAAGACCACCCTGAGCCAGA	0.607000													69	1443					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958704	121958704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121958704G>A	ENST00000379692.4	-	4	948	c.422C>T	c.(421-423)tCc>tTc	p.S141F	NDNF_ENST00000506900.1_5'UTR	NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	141	Poly-Ser.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						ACCGGATGGGGAACTAGACGA	0.413000													40	95					0	0	1	0	0
UPF2	26019	broad.mit.edu	37	10	11978629	11978629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11978629G>A	ENST00000356352.2	-	18	3934	c.3461C>T	c.(3460-3462)cCc>cTc	p.P1154L	UPF2_ENST00000397053.2_Missense_Mutation_p.P1154L|UPF2_ENST00000357604.5_Missense_Mutation_p.P1154L			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	1154	Necessary for interaction with UPF1.|Sufficient for interaction with EIF4A1 and EIF1.|Sufficient for interaction with UPF1 C- terminus.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				TCCCAGTGGGGGCCCTTTCCT	0.463000													45	73					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84537277	84537277	+	Missense_Mutation	SNP	C	C	T	rs142898680	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84537277C>T	ENST00000262753.4	-	16	1841	c.1696G>A	c.(1696-1698)Gaa>Aaa	p.E566K	POF1B_ENST00000373145.3_Missense_Mutation_p.E566K	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	566							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						GGTATATATTCGTAGTCATCA	0.373000													17	17					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228509173	228509173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228509173G>A	ENST00000570156.2	+	66	17576	c.17502G>A	c.(17500-17502)gtG>gtA	p.V5834V	OBSCN_ENST00000366707.4_Silent_p.V2511V|OBSCN_ENST00000422127.1_Silent_p.V4877V|OBSCN_ENST00000284548.11_Silent_p.V4877V|OBSCN_ENST00000366709.4_Silent_p.V1996V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4877	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGCAGCTGTGAAGATCCAGG	0.597000													6	9					0	0	1	0	0
OR10A4	283297	broad.mit.edu	37	11	6898505	6898505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6898505C>T	ENST00000379829.2	+	1	650	c.627C>T	c.(625-627)ctC>ctT	p.L209L		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TATTCATTCTCTTTCCTTTCT	0.507000													41	77					0	0	1	0	0
KERA	11081	broad.mit.edu	37	12	91449884	91449884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91449884C>T	ENST00000266719.3	-	2	422	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	59	LRRNT.				response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						CCTCTATTTTCACAATATAAA	0.373000													31	79					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79240035	79240035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79240035G>A	ENST00000264895.6	+	18	2472	c.2032G>A	c.(2032-2034)Gaa>Aaa	p.E678K	FRAS1_ENST00000325942.6_Missense_Mutation_p.E678K|FRAS1_ENST00000264899.6_Missense_Mutation_p.E678K	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	678					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GAAGCCAGAGGAAGGACTGCA	0.527000													37	70					0	0	1	0	0
MAGEA11	4110	broad.mit.edu	37	X	148798216	148798216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:148798216G>A	ENST00000355220.5	+	5	1172	c.1070G>A	c.(1069-1071)aGg>aAg	p.R357K	MAGEA11_ENST00000333104.4_Missense_Mutation_p.R328K	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	357	MAGE.					cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GAGCCCAAGAGGCTCCTTACC	0.562000													102	78					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286023	48286023	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48286023T>A	ENST00000320048.1	+	1	611	c.611T>A	c.(610-612)aTc>aAc	p.I204N		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GGCGGCTCCATCTCCGTAGTC	0.552000													20	32					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565276	58565276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58565276C>T	ENST00000282326.1	+	6	1331	c.1084C>T	c.(1084-1086)Cca>Tca	p.P362S		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	362					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGAGTCCGTCCCACCCAGGGA	0.662000													16	29					0	0	1	0	0
SLC13A2	9058	broad.mit.edu	37	17	26821441	26821441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26821441C>T	ENST00000444914.3	+	9	1786	c.1366C>T	c.(1366-1368)Ctc>Ttc	p.L456F	SLC13A2_ENST00000314669.5_Missense_Mutation_p.L407F|SLC13A2_ENST00000537681.1_Missense_Mutation_p.L336F|SLC13A2_ENST00000545060.1_Missense_Mutation_p.L364F	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	407						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CCCTCTTGGCCTCCTCGACTG	0.567000											OREG0024276	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	49					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119934769	119934769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119934769G>A	ENST00000361035.4	+	7	1130	c.847G>A	c.(847-849)Ggg>Agg	p.G283R	HAO2_ENST00000325945.3_Missense_Mutation_p.G270R	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	270	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TGCTGTAAAGGGGAAAATTGA	0.488000													15	64					0	0	1	0	0
LGI3	203190	broad.mit.edu	37	8	22006104	22006104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22006104G>A	ENST00000306317.2	-	8	1505	c.1216C>T	c.(1216-1218)Cgc>Tgc	p.R406C	LGI3_ENST00000424267.2_Missense_Mutation_p.R382C	NM_139278.2	NP_644807.1	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	406					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	17				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		TTCTGGGTGCGACTCCACTGA	0.622000													10	28					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122287651	122287651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122287651C>T	ENST00000296161.4	+	3	904	c.715C>T	c.(715-717)Ccc>Tcc	p.P239S	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	239					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		TTTTGAAGTTCCCTTGCCTTA	0.398000													22	56					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25775392	25775392	+	Nonsense_Mutation	SNP	G	G	A	rs146140738	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:25775392G>A	ENST00000428257.1	-	8	1284	c.1177C>T	c.(1177-1179)Cga>Tga	p.R393*	NGLY1_ENST00000280700.5_Nonsense_Mutation_p.R411*|NGLY1_ENST00000467224.1_5'UTR|NGLY1_ENST00000396649.3_Nonsense_Mutation_p.R411*|NGLY1_ENST00000422724.2_3'UTR|NGLY1_ENST00000417874.2_Nonsense_Mutation_p.R369*	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	411					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding	p.R411*(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						ATAGTGTCTCGAAGTAATGCT	0.358000													21	88					0	0	1	0	0
AIM1L	55057	broad.mit.edu	37	1	26664512	26664512	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26664512C>T	ENST00000527815.1	-	7	925	c.876G>A	c.(874-876)ggG>ggA	p.G292G	AIM1L_ENST00000522993.1_5'UTR|AIM1L_ENST00000308182.5_Silent_p.G121G	NM_001039775.3	NP_001034864.2	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	121	Beta/gamma crystallin 'Greek key' 6.						sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|pancreas(1)|skin(2)	12		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		CCCTGGGCTCCCCTGGCTTCT	0.577000													9	15					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87636987	87636987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:87636987G>A	ENST00000284262.2	+	1	477	c.235G>A	c.(235-237)Ggg>Agg	p.G79R		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	79	Gly-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		GGAGAGCAAGGGGAAGTGGGT	0.682000													9	7					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143034	55143034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55143034G>A	ENST00000396331.1	+	5	511	c.154G>A	c.(154-156)Ggc>Agc	p.G52S	LILRB1_ENST00000427581.2_Missense_Mutation_p.G88S|LILRB1_ENST00000434867.2_Missense_Mutation_p.G52S|LILRB1_ENST00000396315.1_Missense_Mutation_p.G52S|LILRB1_ENST00000448689.1_Missense_Mutation_p.G52S|LILRB1_ENST00000418536.2_Missense_Mutation_p.G52S|LILRB1_ENST00000396321.2_Missense_Mutation_p.G52S|LILRB1_ENST00000324602.7_Missense_Mutation_p.G52S|LILRB1_ENST00000396317.1_Missense_Mutation_p.G52S|LILRB1_ENST00000396332.4_Missense_Mutation_p.G52S|LILRB1_ENST00000396327.3_Missense_Mutation_p.G52S	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	52	Ig-like C2-type 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GTGTCAGGGGGGCCAGGAGAC	0.572000										HNSCC(37;0.09)			50	101					0	0	1	0	0
ICAM2	3384	broad.mit.edu	37	17	62082713	62082713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62082713C>T	ENST00000412356.1	-	4	436	c.82G>A	c.(82-84)Gag>Aag	p.E28K	ICAM2_ENST00000581417.1_5'UTR|ICAM2_ENST00000449662.2_Missense_Mutation_p.E28K|ICAM2_ENST00000578379.1_5'UTR|ICAM2_ENST00000579788.1_Missense_Mutation_p.E28K|ICAM2_ENST00000418105.1_Missense_Mutation_p.E28K|ICAM2_ENST00000578892.1_Missense_Mutation_p.E28K|ICAM2_ENST00000579687.1_Missense_Mutation_p.E28K	NM_001099786.1	NP_001093256.1	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2	28					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			large_intestine(1)|lung(2)|ovary(1)|skin(2)	6						ACGTGTACCTCGAATACCTTC	0.582000													6	47					0	0	1	0	0
BMP7	655	broad.mit.edu	37	20	55803379	55803379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:55803379C>T	ENST00000395863.3	-	2	1022	c.517G>A	c.(517-519)Gaa>Aaa	p.E173K	BMP7_ENST00000395864.3_Missense_Mutation_p.E173K|BMP7_ENST00000450594.2_Missense_Mutation_p.E173K	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7	173					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity	p.E173K(1)		endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			ATCCGGAATTCGGCTGCCGTG	0.537000													70	136					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51555737	51555737	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:51555737C>T	ENST00000358559.2	+	2	97	c.10C>T	c.(10-12)Ctc>Ttc	p.L4F	MSMB_ENST00000298239.6_Missense_Mutation_p.L4F|MSMB_ENST00000474170.1_3'UTR	NM_002443.3	NP_002434.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	4						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						ACAGAATGTTCTCCTGGGCAG	0.458000													17	40					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914895	46914895	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46914895C>T	ENST00000307522.3	-	1	1946	c.1173G>A	c.(1171-1173)caG>caA	p.Q391Q		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	391						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CCTCCGCCCTCTGATTATCTG	0.587000													39	190					0	0	1	0	0
DAND5	199699	broad.mit.edu	37	19	13084385	13084385	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13084385C>T	ENST00000317060.2	+	2	686	c.507C>T	c.(505-507)tcC>tcT	p.S169S	DAND5_ENST00000585548.1_3'UTR	NM_152654.2	NP_689867.1	Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	169	CTCK.					extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			GCTCAGCCTCCCGTCGACGGG	0.612000													37	84					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154139092	154139092	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:154139092T>A	ENST00000389740.2	-	3	1458	c.1359A>T	c.(1357-1359)aaA>aaT	p.K453N		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	453						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGATTTCTACTTTTATAGCAT	0.398000													53	203					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108070663	108070663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108070663G>A	ENST00000467562.1	+	4	247	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	HHLA2_ENST00000491820.1_Start_Codon_SNP_p.M1I|HHLA2_ENST00000357759.5_Start_Codon_SNP_p.M1I|HHLA2_ENST00000467761.1_Start_Codon_SNP_p.M1I|HHLA2_ENST00000489514.2_Start_Codon_SNP_p.M1I			Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	0						integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						CACAAGACATGAAGGCACAGA	0.358000													17	23					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19369408	19369408	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19369408C>T	ENST00000291481.7	-	4	804	c.741G>A	c.(739-741)ggG>ggA	p.G247G	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	247	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			TGCGCAGGCCCCCGTTGGCAT	0.697000													5	51					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42635205	42635205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42635205G>A	ENST00000358131.5	+	3	419	c.211G>A	c.(211-213)Gag>Aag	p.E71K	TOX2_ENST00000372999.1_Missense_Mutation_p.E20K|TOX2_ENST00000423191.1_Missense_Mutation_p.E20K|TOX2_ENST00000341197.3_Missense_Mutation_p.E62K	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CGGCCAGAGCGAGAACAACGA	0.547000													39	102					0	0	1	0	0
RFPL1S	10740	broad.mit.edu	37	22	29833658	29833658	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29833658C>T	ENST00000461286.2	-	0	4718					NR_002727.2																						GTGCCCCTTCCGCACAAGACC	0.522000													6	26					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97426937	97426937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97426937C>T	ENST00000377075.2	+	1	299	c.201C>T	c.(199-201)ttC>ttT	p.F67F		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	67					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GCATCATCTTCGTGTCCGAGG	0.647000													16	47					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5436228	5436228	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:5436228C>T	ENST00000345221.3	-	11	3764	c.3210G>A	c.(3208-3210)acG>acA	p.T1070T	NLRP1_ENST00000354411.3_Silent_p.T1040T|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000262467.5_Silent_p.T1074T|NLRP1_ENST00000577119.1_Silent_p.T1040T|NLRP1_ENST00000572272.1_Silent_p.T1070T|NLRP1_ENST00000269280.4_Silent_p.T1070T	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	1070					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				CCAAAGGCTTCGTATGCAGGT	0.577000													23	34					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28722112	28722112	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28722112C>T	ENST00000257197.3	-	9	1371	c.1110G>A	c.(1108-1110)gtG>gtA	p.V370V	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Silent_p.V370V	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	370	Cadherin 3.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GTAAAATCTCCACGTCAATTC	0.333000													19	82					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129070703	129070703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:129070703G>A	ENST00000274487.4	+	22	3518	c.3373G>A	c.(3373-3375)Gaa>Aaa	p.E1125K	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1125	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ACATGGAAATGAATGTTTTTC	0.418000													27	76					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31323334	31323334	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:31323334G>A	ENST00000542188.1	-	22	3343	c.3030C>T	c.(3028-3030)gtC>gtT	p.V1010V	TRPM1_ENST00000256552.6_Silent_p.V993V|TRPM1_ENST00000397795.2_Silent_p.V971V|RP11-348B17.1_ENST00000558755.1_RNA|RP11-348B17.1_ENST00000561299.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	971					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CCAGCATGATGACCACAAAGT	0.493000													34	78					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463744	25463744	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25463744G>A	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						GCATGTGCGGGAAGGGGGGTG	0.542000													110	216					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20582410	20582410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20582410C>T	ENST00000202677.6	-	16	2261	c.2119G>A	c.(2119-2121)Gaa>Aaa	p.E707K	RALGAPA2_ENST00000495793.1_5'UTR	NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	707					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						CGCATCGGTTCGGTCACATCT	0.478000													17	47					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896748	175896748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175896748C>T	ENST00000359240.3	+	5	742	c.72C>T	c.(70-72)caC>caT	p.H24H	ADAM29_ENST00000404450.4_Silent_p.H24H|ADAM29_ENST00000445694.1_Silent_p.H24H|ADAM29_ENST00000514159.1_Silent_p.H24H	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	24					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AGGATGAGCACCCCCAATATC	0.512000													19	56					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880658	142880658	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142880658C>T	ENST00000446620.1	+	1	147	c.147C>T	c.(145-147)atC>atT	p.I49I		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	49					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					TCATTGGTATCATTGCAAATG	0.408000													31	45					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71418430	71418430	+	Missense_Mutation	SNP	C	C	T	rs140473608	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:71418430C>T	ENST00000392650.3	-	15	2041	c.2041G>A	c.(2041-2043)Gag>Aag	p.E681K	SDK2_ENST00000388726.3_Missense_Mutation_p.E681K	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	681	Fibronectin type-III 1.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CCTCACCTCTCGGTGTCTTTG	0.607000													23	48					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79434665	79434665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:79434665G>A	ENST00000554719.1	+	11	2490	c.1999G>A	c.(1999-2001)Gga>Aga	p.G667R	NRXN3_ENST00000335750.5_Missense_Mutation_p.G667R	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TCATCGGAGCGGACAGATCGA	0.522000													23	52					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49407996	49407996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49407996C>T	ENST00000299191.3	+	1	263	c.146C>T	c.(145-147)cCc>cTc	p.P49L		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	49										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						AAACAAGCTCCCGAGGTGGGT	0.507000													18	62					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3784232	3784232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3784232C>T	ENST00000310132.6	-	5	650	c.252G>A	c.(250-252)aaG>aaA	p.K84K	MATK_ENST00000585778.1_Silent_p.K84K|MATK_ENST00000395045.2_Silent_p.K85K|MATK_ENST00000395040.2_Silent_p.K43K	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	84	SH3.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTACCAGCTCTTGTTCTGCC	0.697000													15	49					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10279981	10279981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:10279981G>A	ENST00000254976.2	+	7	684	c.473G>A	c.(472-474)gGg>gAg	p.G158E	SNAP25-AS1_ENST00000421143.2_RNA|SNAP25_ENST00000495883.1_3'UTR|SNAP25_ENST00000304886.2_Missense_Mutation_p.G158E|SNAP25-AS1_ENST00000453544.1_RNA	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	158	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	GGCATCATCGGGAACCTCCGT	0.502000													38	141					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43500853	43500853	+	Missense_Mutation	SNP	C	C	T	rs143974871	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43500853C>T	ENST00000300215.3	-	7	1500	c.1043G>A	c.(1042-1044)gGc>gAc	p.G348D	EPB42_ENST00000540029.1_Missense_Mutation_p.G240D|EPB42_ENST00000441366.2_Missense_Mutation_p.G318D			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	318					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GCCTCTCTGGCCTTCTCCGTT	0.587000													30	332					0	0	1	0	0
LMBR1	64327	broad.mit.edu	37	7	156619309	156619309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:156619309G>A	ENST00000353442.4	-	4	545	c.309C>T	c.(307-309)tcC>tcT	p.S103S	LMBR1_ENST00000354505.4_Silent_p.S103S|LMBR1_ENST00000540390.1_Silent_p.S82S	NM_022458.3	NP_071903.2	Q8WVP7	LMBR1_HUMAN	limb development membrane protein 1	103						integral to membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	18	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		CATGAATCAGGGAGCCATTTA	0.323000													8	8					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11964828	11964828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11964828C>T	ENST00000256720.2	+	20	2677	c.2584C>T	c.(2584-2586)Ccc>Tcc	p.P862S	LPIN1_ENST00000404113.2_Missense_Mutation_p.P363S|LPIN1_ENST00000449576.2_Missense_Mutation_p.P947S|LPIN1_ENST00000425416.2_Missense_Mutation_p.P868S|LPIN1_ENST00000396099.1_Missense_Mutation_p.P904S|LPIN1_ENST00000396097.1_Missense_Mutation_p.P592S	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	862					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		TTCAGACTTTCCCTGTTCGGA	0.473000													32	62					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19947154	19947154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:19947154C>T	ENST00000295824.9	-	6	1537	c.1376G>A	c.(1375-1377)cGa>cAa	p.R459Q	EFHB_ENST00000344838.4_Missense_Mutation_p.R329Q|EFHB_ENST00000498089.1_5'UTR	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	459					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						TGCCATGGCTCGTCCATCATT	0.383000													33	87					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113703756	113703756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113703756G>A	ENST00000374431.3	-	4	1121	c.738C>T	c.(736-738)ccC>ccT	p.P246P	LPAR1_ENST00000541779.1_Silent_p.P247P|LPAR1_ENST00000358883.4_Silent_p.P246P|LPAR1_ENST00000538760.1_Silent_p.P247P|LPAR1_ENST00000374430.2_Silent_p.P246P	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	246					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						GATTCCGCCGGGGTCCAGAAC	0.453000													23	55					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54955914	54955914	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54955914C>T	ENST00000173898.7	+	12	2869	c.2757C>T	c.(2755-2757)ttC>ttT	p.F919F	TRO_ENST00000319167.8_Intron|TRO_ENST00000420798.2_Silent_p.F450F|TRO_ENST00000375041.2_Silent_p.F522F|TRO_ENST00000399736.1_Intron|TRO_ENST00000375022.4_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	919	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GTATCTGCTTCGGTGGCTCTC	0.552000													16	22					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575565	136575565	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136575565C>T	ENST00000264162.2	-	6	1063	c.1053G>A	c.(1051-1053)acG>acA	p.T351T		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	351	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGAGGAGTCCGTGGTCTCGT	0.542000													30	77					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	101031041	101031041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101031041G>A	ENST00000284382.4	-	5	692	c.269C>T	c.(268-270)tCc>tTc	p.S90F	CERS3_ENST00000394113.1_Missense_Mutation_p.S90F|CERS3_ENST00000538112.2_Missense_Mutation_p.S90F|CERS3_ENST00000560944.1_Intron	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	90						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										TTGCCTTGTGGAATGTTTGAA	0.338000													13	65					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48541212	48541212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48541212C>T	ENST00000427954.2	+	10	1198	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	ACSF2_ENST00000504392.1_Silent_p.F317F|ACSF2_ENST00000541920.1_Silent_p.F200F|ACSF2_ENST00000300441.4_Silent_p.F360F|ACSF2_ENST00000502667.1_Silent_p.F347F			Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	360					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CCACGATGTTCGTGGACATTC	0.577000													46	97					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183721410	183721410	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183721410G>A	ENST00000511685.1	+	28	8129	c.8006G>A	c.(8005-8007)gGg>gAg	p.G2669E	TENM3_ENST00000406950.2_Missense_Mutation_p.G2669E					teneurin transmembrane protein 3																		GGCTACGACGGGTACTACGTA	0.692000													3	15					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17474704	17474704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17474704C>T	ENST00000302539.4	-	7	1263	c.1138G>A	c.(1138-1140)Gcc>Acc	p.A380T	ABCC8_ENST00000389817.3_Missense_Mutation_p.A380T	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	380	ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GTTTCAATGGCCACATAGTAG	0.418000													27	98					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58551861	58551861	+	Silent	SNP	C	C	T	rs147151087		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58551861C>T	ENST00000282326.1	+	4	661	c.414C>T	c.(412-414)ttC>ttT	p.F138F		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	138					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		ACTGGAGTTTCGGTGAGGAGG	0.612000													10	177					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671680	31671680	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31671680G>A	ENST00000375483.3	+	3	677	c.677_splice	c.e3+1	p.G226_splice		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	226	Gly-rich.					cytoplasm|extracellular region	lipid binding										GGCATCACGGGGTAAGGAGGG	0.622000													5	33					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122787290	122787290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122787290G>A	ENST00000194130.2	-	7	774	c.735C>T	c.(733-735)gcC>gcT	p.A245A	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	245						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TAGAAGAGTAGGCAATGCACA	0.413000													9	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065468	9065468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9065468G>A	ENST00000397910.4	-	3	22181	c.21978C>T	c.(21976-21978)atC>atT	p.I7326I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7328	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTGGGTCTTGATGGTCATTT	0.443000													5	59					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60785320	60785320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60785320C>T	ENST00000313421.7	+	11	1858	c.1672C>T	c.(1672-1674)Ccg>Tcg	p.P558S	CD6_ENST00000352009.5_Missense_Mutation_p.P526S|CD6_ENST00000346437.4_Missense_Mutation_p.P485S|CD6_ENST00000344028.5_Missense_Mutation_p.P526S|CD6_ENST00000452451.2_Missense_Mutation_p.P517S	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	558					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						TCAGTATCACCCGAGGAGCAA	0.552000													35	84					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155505308	155505308	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155505308G>A	ENST00000302053.3	-	6	2647	c.2569C>T	c.(2569-2571)Cgc>Tgc	p.R857C		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	857	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding	p.R857C(1)		NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ATTTTCATGCGAACAGCCCTG	0.473000													13	133					0	0	1	0	0
PLGLA	285189	broad.mit.edu	37	2	107004058	107004058	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107004058G>A	ENST00000484422.1	+	0	147																											TGTGATAATGGCTGAAAACAA	0.348000													54	190					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33588192	33588192	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33588192G>A	ENST00000262873.7	+	37	5096	c.5004G>A	c.(5002-5004)gaG>gaA	p.E1668E		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1626						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGAAGATGGAGGGTGACCTCA	0.657000													43	95					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114185980	114185980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:114185980G>A	ENST00000297405.5	-	4	924	c.680C>T	c.(679-681)tCg>tTg	p.S227L	CSMD3_ENST00000352409.3_Missense_Mutation_p.S227L|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Missense_Mutation_p.S187L|CSMD3_ENST00000455883.2_Missense_Mutation_p.S227L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	227	Sushi 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAAATCCCACGAAGCTGTATT	0.433000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	132					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848392	54848392	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54848392G>A	ENST00000291759.4	-	6	1031	c.975C>T	c.(973-975)tcC>tcT	p.S325S	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	325	Ig-like C2-type 4.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GCACTGAGAGGGAGGGTCTGT	0.607000													17	54					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774727	140774727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140774727G>A	ENST00000398604.2	+	1	2347	c.2347G>A	c.(2347-2349)Gag>Aag	p.E783K	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCAGTCAGGAGGGCTGTGA	0.473000													27	120					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3638758	3638758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3638758G>A	ENST00000378295.4	+	5	758	c.603G>A	c.(601-603)agG>agA	p.R201R	TP73_ENST00000378285.1_Silent_p.R152R|TP73_ENST00000604479.1_Silent_p.R201R|TP73_ENST00000378288.4_Silent_p.R152R|TP73_ENST00000354437.4_Silent_p.R201R|TP73_ENST00000603362.1_Silent_p.R201R|TP73_ENST00000378290.4_Silent_p.R130R|TP73_ENST00000357733.3_Silent_p.R201R|TP73_ENST00000378280.1_Silent_p.R152R|TP73_ENST00000604074.1_Silent_p.R201R|TP73_ENST00000346387.4_Silent_p.R201R	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	201	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		AGCTCGGGAGGGACTTCAACG	0.662000													13	29					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73676650	73676650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73676650C>T	ENST00000264448.6	+	8	3104	c.2993C>T	c.(2992-2994)cCt>cTt	p.P998L	ALMS1_ENST00000409009.1_Missense_Mutation_p.P956L|ALMS1_ENST00000377715.1_Missense_Mutation_p.P998L	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	998	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CCAACAGTACCTTCAGGTTCC	0.453000													50	120					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53012211	53012211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53012211C>T	ENST00000305748.3	-	1	132	c.98G>A	c.(97-99)cGa>cAa	p.R33Q		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	33	Gly-rich.|Head.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCCCCTGCTCGGTAGGAGGA	0.637000													39	111					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67221470	67221470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67221470C>T	ENST00000314586.6	-	5	938	c.698G>A	c.(697-699)cGa>cAa	p.R233Q	EXOC3L1_ENST00000562887.1_Intron	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	233	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						GGGGGTTGTTCGTCCAGTCTC	0.687000													10	53					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12958036	12958036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:12958036G>A	ENST00000276297.4	-	9	2219	c.1810C>T	c.(1810-1812)Ccc>Tcc	p.P604S	DLC1_ENST00000358919.2_Missense_Mutation_p.P167S|DLC1_ENST00000520226.1_Missense_Mutation_p.P93S|DLC1_ENST00000512044.2_Missense_Mutation_p.P201S	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	604					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCGTGGCTGGGGAGGCTGCCA	0.672000													10	86					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058002	79058002	+	Silent	SNP	C	C	T	rs143941580		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79058002C>T	ENST00000388820.4	-	19	4461	c.4251G>A	c.(4249-4251)gcG>gcA	p.A1417A		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1417	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.A1417A(1)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						TCCAGTTTCCCGCTTGCCAGC	0.642000													40	94					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179408973	179408973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179408973C>T	ENST00000589042.1	-	345	96207	c.95983G>A	c.(95983-95985)Gaa>Aaa	p.E31995K	TTN_ENST00000342992.6_Missense_Mutation_p.E29427K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E22930K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E23122K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E23055K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E30354K|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30354	Ig-like 142.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCGCTGTATTCGCTCATACCC	0.408000													27	52					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64649419	64649419	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:64649419C>T	ENST00000587624.1	+	0	1200																											CAAGAGGATCCTTCGCAGCAG	0.502000													23	71					0	0	1	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79629625	79629625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:79629625C>T	ENST00000263849.4	+	9	977	c.875C>T	c.(874-876)tCa>tTa	p.S292L		NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	292																	GAAGGACATTCACCTGGAAAC	0.383000													47	123					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38186485	38186485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38186485C>T	ENST00000373048.4	-	12	2177	c.2178G>A	c.(2176-2178)atG>atA	p.M726I	EPHA10_ENST00000540011.1_3'UTR|EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000427468.2_Missense_Mutation_p.M726I|EPHA10_ENST00000330210.7_Missense_Mutation_p.M221I	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	726	Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCCATGGCTCATGTACTCGG	0.572000													30	49					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25326463	25326463	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25326463C>T	ENST00000546682.1	+	0	71				SNORD116-15_ENST00000384445.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TATATACATTCCTTGGAAAGC	0.458000													76	197					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5892017	5892017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:5892017C>T	ENST00000581347.1	-	3	691	c.46G>A	c.(46-48)Gat>Aat	p.D16N	TMEM200C_ENST00000383490.2_Missense_Mutation_p.D16N|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	16						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						CGGAGTGGATCCTGCTTTCTG	0.612000													10	28					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33696629	33696629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33696629G>A	ENST00000253193.7	+	5	1155	c.953G>A	c.(952-954)gGg>gAg	p.G318E		NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	318	CUB 2.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					GGCGAGCGCGGGGACCGCCTG	0.711000													3	23					0	0	1	0	0
TREML1	340205	broad.mit.edu	37	6	41121769	41121769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41121769G>A	ENST00000373127.4	-	2	151	c.103C>T	c.(103-105)Ctg>Ttg	p.L35L	TREML1_ENST00000426005.2_Silent_p.L35L|TREML1_ENST00000437044.2_Intron	NM_001271807.1	NP_001258736.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	35	Ig-like V-type.				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					CACTGCACCAGAATGGAGCTT	0.617000													11	31					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36170360	36170360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:36170360G>A	ENST00000335119.2	+	1	972	c.861G>A	c.(859-861)caG>caA	p.Q287Q		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	287					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			TCGGTGGCCAGAAGGCCCACG	0.572000													10	74					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	652761	652761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:652761G>A	ENST00000255622.6	+	11	1465	c.1422G>A	c.(1420-1422)ggG>ggA	p.G474G	PDE6B_ENST00000429163.2_Silent_p.G195G|PDE6B_ENST00000496514.1_Silent_p.G474G	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	474					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						CGCGCCTGGGGAAGGAGCCTG	0.622000													12	56					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	91996156	91996156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91996156G>A	ENST00000450295.1	-	14	2328	c.1552C>T	c.(1552-1554)Ccc>Tcc	p.P518S	SEMA4D_ENST00000356444.2_Missense_Mutation_p.P518S|SEMA4D_ENST00000339861.4_Missense_Mutation_p.P518S|SEMA4D_ENST00000438547.2_Missense_Mutation_p.P518S|SEMA4D_ENST00000455551.2_Missense_Mutation_p.P518S|SEMA4D_ENST00000422704.2_Missense_Mutation_p.P518S|SEMA4D_ENST00000420987.1_Missense_Mutation_p.P518S|SEMA4D_ENST00000343780.4_Missense_Mutation_p.P518S			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	518	PSI.				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						GCGCAGTAGGGGTCCCGCGCC	0.687000													10	13					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55136093	55136093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55136093C>T	ENST00000314706.3	+	1	734	c.734C>T	c.(733-735)tCc>tTc	p.S245F		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						ATCCTGCTTTCCTATGGGGTC	0.428000													36	88					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88690576	88690576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88690576G>A	ENST00000394480.1	-	6	775	c.454C>T	c.(454-456)Ctt>Ttt	p.L152F	NTRK3_ENST00000558676.1_Missense_Mutation_p.L152F|NTRK3_ENST00000357724.2_Missense_Mutation_p.L152F|NTRK3_ENST00000317501.3_Missense_Mutation_p.L152F|NTRK3_ENST00000355254.2_Missense_Mutation_p.L152F|NTRK3_ENST00000542733.2_Missense_Mutation_p.L54F|NTRK3_ENST00000540489.2_Missense_Mutation_p.L152F|NTRK3_ENST00000360948.2_Missense_Mutation_p.L152F|NTRK3_ENST00000557856.1_Missense_Mutation_p.L152F	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	152					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.L152I(1)	ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AATTCCCGAAGACTCAGCGTC	0.478000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			19	61					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686806	68686806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:68686806G>A	ENST00000361320.4	+	2	710	c.132G>A	c.(130-132)atG>atA	p.M44I	CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	44	LRRNT.					integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						AAGGCAAAATGGTATATTGTG	0.443000													24	53					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114377567	114377567	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114377567C>T	ENST00000359785.5	-	14	1994	c.1859G>A	c.(1858-1860)tGg>tAg	p.W620*	PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000525799.1_Nonsense_Mutation_p.W493*|PTPN22_ENST00000528414.1_Nonsense_Mutation_p.W565*|PTPN22_ENST00000538253.1_Nonsense_Mutation_p.W376*|PTPN22_ENST00000420377.2_Nonsense_Mutation_p.W620*	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	620			R -> W (confers susceptibility to systemic lupus erythematosus and type 1 diabetes mellitus; affects CSK kinase binding; dbSNP:rs2476601).		negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCAGGTGTCCATACAGGAAG	0.383000													13	193					0	0	1	0	0
OR1D2	4991	broad.mit.edu	37	17	2995949	2995949	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:2995949G>A	ENST00000331459.1	-	1	341	c.342C>T	c.(340-342)atC>atT	p.I114I		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	114					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						TCACAGCCAGGATGAGGTTGT	0.542000													52	65					0	0	1	0	0
MIR100	406892	broad.mit.edu	37	11	122023001	122023001	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:122023001G>A	ENST00000385259.1	-	0	15					NR_029515.1																						CGGATCTACGGGTTTGTGGCA	0.413000													21	48					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40363885	40363885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40363885C>T	ENST00000221347.6	-	31	14764	c.14757G>A	c.(14755-14757)gtG>gtA	p.V4919V		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4919	VWFD 12.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAGCTAGGCTCACAACCTGGC	0.607000													17	49					0	0	1	0	0
RHBDF2	79651	broad.mit.edu	37	17	74475819	74475819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74475819G>A	ENST00000591885.1	-	4	818	c.268C>T	c.(268-270)Cgc>Tgc	p.R90C	RHBDF2_ENST00000389760.4_Missense_Mutation_p.R90C|RHBDF2_ENST00000592378.1_Intron|RHBDF2_ENST00000313080.4_Missense_Mutation_p.R119C			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	119					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity	p.R119C(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						GCTCACTTGCGGATGCTCTGG	0.662000													6	21					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13910382	13910382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:13910382C>T	ENST00000294489.6	+	1	423	c.82C>T	c.(82-84)Ctc>Ttc	p.L28F	PDPN_ENST00000376057.4_Missense_Mutation_p.L28F			Q86YL7	PDPN_HUMAN	podoplanin	0					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		GGCACCCTCCCTCTCCGGGGC	0.647000													22	43					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047558	42047558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42047558G>A	ENST00000372584.1	-	3	3925	c.2911C>T	c.(2911-2913)Ctg>Ttg	p.L971L	HIVEP3_ENST00000247584.5_Silent_p.L971L|HIVEP3_ENST00000372583.1_Silent_p.L971L|HIVEP3_ENST00000429157.2_Silent_p.L971L	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	971	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGGTGCCCAGGGGTTTGGGG	0.617000													16	89					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166167071	166167071	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166167071C>T	ENST00000375437.2	+	7	1226	c.936C>T	c.(934-936)agC>agT	p.S312S	SCN2A_ENST00000375427.2_Silent_p.S312S|SCN2A_ENST00000357398.3_Silent_p.S312S|SCN2A_ENST00000283256.6_Silent_p.S312S	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	312					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GGACAGTGAGCATATTTAACT	0.289000													18	47					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491647	100491647	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100491647C>T	ENST00000302913.4	-	2	345	c.207G>A	c.(205-207)gcG>gcA	p.A69A	ACHE_ENST00000411582.1_Silent_p.A69A|ACHE_ENST00000241069.5_Silent_p.A69A|ACHE_ENST00000428317.1_Silent_p.A69A|ACHE_ENST00000412389.1_Silent_p.A69A|ACHE_ENST00000419336.2_Silent_p.A69A	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	69					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	TGGGTGGCTCCGCAAAGGGGA	0.652000													7	24					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43670062	43670062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43670062C>T	ENST00000564079.1	+	5	642	c.402C>T	c.(400-402)ccC>ccT	p.P134P	TUBGCP4_ENST00000399460.3_5'UTR|TUBGCP4_ENST00000260383.7_Silent_p.P134P	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	134					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		TTCTTTTTCCCTCTGTGATGG	0.323000													29	103					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74332987	74332987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:74332987G>A	ENST00000377044.4	-	13	2815	c.2276C>T	c.(2275-2277)cCt>cTt	p.P759L	TMEM2_ENST00000377066.5_Missense_Mutation_p.P696L	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	759						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		ATCCTGATGAGGTCGAAATCT	0.348000													13	103					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186106	127186106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:127186106C>T	ENST00000371124.3	-	1	276	c.80G>A	c.(79-81)gGa>gAa	p.G27E		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	27						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						TCCAATCTCTCCAGACAGGCC	0.443000													9	42					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54822693	54822693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54822693G>A	ENST00000301219.3	-	5	822	c.703C>T	c.(703-705)Ccg>Tcg	p.P235S	LILRA5_ENST00000346508.3_Missense_Mutation_p.P223S|LILRA5_ENST00000446712.3_Missense_Mutation_p.P223S|LILRA5_ENST00000432233.3_Missense_Mutation_p.P235S|AC008984.2_ENST00000507363.1_RNA	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	235					innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCTGAGACCGGAATCTCCAGG	0.567000													36	80					0	0	1	0	0
SHD	56961	broad.mit.edu	37	19	4284825	4284825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4284825G>A	ENST00000543264.2	+	4	2103	c.640G>A	c.(640-642)Gag>Aag	p.E214K	SHD_ENST00000599689.1_Missense_Mutation_p.E214K|SHD_ENST00000600475.1_3'UTR	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	214										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAGCCAAGGAGCTCCGGAG	0.617000													14	49					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57088760	57088760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57088760C>T	ENST00000330619.8	+	6	1649	c.963C>T	c.(961-963)ttC>ttT	p.F321F	ZNF470_ENST00000391709.3_Silent_p.F321F|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ATAAAGCATTCAGCCAGCTTG	0.448000													27	51					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86518066	86518066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:86518066G>A	ENST00000297814.2	-	4	1510	c.1367C>T	c.(1366-1368)tCa>tTa	p.S456L	KIF27_ENST00000413982.1_Missense_Mutation_p.S456L|KIF27_ENST00000334204.2_Missense_Mutation_p.S456L	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	456					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TCCTCGAAATGAGGTGAGGAC	0.463000													19	65					0	0	1	0	0
GPR55	9290	broad.mit.edu	37	2	231775112	231775112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231775112C>T	ENST00000392040.1	-	2	758	c.566G>A	c.(565-567)gGc>gAc	p.G189D	GPR55_ENST00000392039.2_Missense_Mutation_p.G189D	NM_005683.3	NP_005674.2	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	189					activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			endometrium(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		AAGGAGGAAGCCAAACACCTC	0.547000													31	121					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18674337	18674337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18674337C>T	ENST00000406451.3	+	8	1025	c.875C>T	c.(874-876)tCg>tTg	p.S292L	HDAC9_ENST00000417496.2_Missense_Mutation_p.S290L|HDAC9_ENST00000441542.2_Missense_Mutation_p.S295L|HDAC9_ENST00000432645.2_Missense_Mutation_p.S292L|HDAC9_ENST00000401921.1_Missense_Mutation_p.S251L|HDAC9_ENST00000406072.1_Missense_Mutation_p.S279L|HDAC9_ENST00000428307.2_Missense_Mutation_p.S248L|HDAC9_ENST00000456174.2_Missense_Mutation_p.S264L|HDAC9_ENST00000524023.1_Missense_Mutation_p.S215L|HDAC9_ENST00000405010.3_Missense_Mutation_p.S292L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	292	Interaction with MAPK10 (By similarity).				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	AATGAGACTTCGGTTTTGCCC	0.403000													5	10					0	0	1	0	0
MCMDC2	157777	broad.mit.edu	37	8	67803171	67803171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:67803171C>T	ENST00000422365.2	+	10	1316	c.1145C>T	c.(1144-1146)aCt>aTt	p.T382I	MCMDC2_ENST00000313616.5_Missense_Mutation_p.T382I|MCMDC2_ENST00000541540.1_Missense_Mutation_p.T319I|MCMDC2_ENST00000396592.3_Missense_Mutation_p.T382I	NM_173518.4	NP_775789.3	Q4G0Z9	CH045_HUMAN	minichromosome maintenance domain containing 2	382					DNA replication		ATP binding|DNA binding			endometrium(2)|kidney(2)|lung(5)	9						ATTTTTCCCACTCTATCCAGG	0.408000													34	108					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65234028	65234028	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65234028C>T	ENST00000389722.3	-	30	6315	c.6262G>A	c.(6262-6264)Gag>Aag	p.E2088K	SPTB_ENST00000389720.3_Intron|SPTB_ENST00000389721.5_Missense_Mutation_p.E2088K|SPTB_ENST00000556626.1_Missense_Mutation_p.E2088K|SPTB_ENST00000542895.1_Missense_Mutation_p.E2088K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	2088					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CACCCAGTCTCCTCTGCGGGT	0.577000													59	246					0	0	1	0	0
GOT2	2806	broad.mit.edu	37	16	58757655	58757655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58757655G>A	ENST00000245206.5	-	2	369	c.241C>T	c.(241-243)Cgc>Tgc	p.R81C	GOT2_ENST00000564400.1_5'UTR|GOT2_ENST00000434819.2_Missense_Mutation_p.R81C	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	81					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTCACCTTGCGGACGCTAGGC	0.498000													20	204					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24509843	24509843	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:24509843C>T	ENST00000264463.4	-	7	1595	c.1088G>A	c.(1087-1089)gGa>gAa	p.G363E		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	363	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TTTAAATGGTCCTAGGTAATA	0.373000										HNSCC(23;0.051)			14	57					0	0	1	0	0
NCL	4691	broad.mit.edu	37	2	232320840	232320840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:232320840G>A	ENST00000322723.4	-	12	1953	c.1713C>T	c.(1711-1713)tcC>tcT	p.S571S		NM_005381.2	NP_005372.2	P19338	NUCL_HUMAN	nucleolin	571					angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		ACAGAGTTTTGGATGGCTCTG	0.438000													16	50					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49211924	49211924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49211924C>T	ENST00000327979.2	-	16	2431	c.2020G>A	c.(2020-2022)Gca>Aca	p.A674T	FAM65C_ENST00000045083.2_Missense_Mutation_p.A674T|FAM65C_ENST00000535356.1_Missense_Mutation_p.A678T			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	674										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ATGGATGTTGCCTTGCCGACC	0.552000													43	103					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6606396	6606396	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6606396C>T	ENST00000433363.2	-	5	842	c.609G>A	c.(607-609)agG>agA	p.R203R	SLC13A5_ENST00000381074.4_Silent_p.R160R|SLC13A5_ENST00000573648.1_Silent_p.R203R|SLC13A5_ENST00000293800.6_Silent_p.R186R	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	203						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						CCTTACACAACCTCTTCCGCT	0.627000													32	52					0	0	1	0	0
CSNK1D	1453	broad.mit.edu	37	17	80209291	80209291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80209291G>A	ENST00000314028.6	-	6	1198	c.849C>T	c.(847-849)tcC>tcT	p.S283S	CSNK1D_ENST00000578904.1_5'UTR|CSNK1D_ENST00000398519.5_Silent_p.S283S|CSNK1D_ENST00000392334.2_Silent_p.S283S	NM_001893.4	NP_001884.2	P48730	KC1D_HUMAN	casein kinase 1, delta	283					circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|large_intestine(2)|lung(7)	11	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			CGTAGTCATAGGAGAAGCCCT	0.532000													12	40					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156787340	156787340	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156787340C>T	ENST00000347377.6	+	25	3299	c.2868C>T	c.(2866-2868)ccC>ccT	p.P956P	CYFIP2_ENST00000541131.1_Silent_p.P881P|CYFIP2_ENST00000318218.6_Silent_p.P981P|CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000521420.1_Silent_p.P930P|CYFIP2_ENST00000522463.1_Silent_p.P760P|CYFIP2_ENST00000377576.3_Silent_p.P956P|CYFIP2_ENST00000435847.2_Silent_p.P655P	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	981					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGGTGATGCCCAAGATATGCC	0.527000													53	107					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1651957	1651957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1651957C>T	ENST00000252804.4	-	17	3645	c.3595G>A	c.(3595-3597)Gag>Aag	p.E1199K		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1199					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TTCAGTTTCTCCCGGATCTCA	0.517000													46	213					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109694813	109694813	+	Missense_Mutation	SNP	C	C	T	rs140162353	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:109694813C>T	ENST00000465301.2	+	3	1214	c.968C>T	c.(967-969)cCg>cTg	p.P323L	RGAG1_ENST00000540313.1_Missense_Mutation_p.P323L	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	323										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						ATGTCCACACCGCTACTGTCA	0.498000													11	240					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56757189	56757189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56757189C>T	ENST00000326855.2	+	1	843	c.801C>T	c.(799-801)tcC>tcT	p.S267S		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						CTAATAATTCCCAGGAAAATA	0.363000													29	64					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17692204	17692204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:17692204C>T	ENST00000399080.2	-	3	3370	c.3347G>A	c.(3346-3348)gGc>gAc	p.G1116D		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	1116	Interaction with RAD51.									endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TCTTGAAATGCCATGTGGAAA	0.323000													4	22					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933018	43933018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43933018C>T	ENST00000537548.1	-	4	737	c.493G>A	c.(493-495)Ggc>Agc	p.G165S	MATN4_ENST00000372754.1_Missense_Mutation_p.G165S|MATN4_ENST00000342716.4_Missense_Mutation_p.G165S|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000372751.4_Intron|MATN4_ENST00000353917.5_Missense_Mutation_p.G165S|MATN4_ENST00000372756.1_Missense_Mutation_p.G165S|MATN4_ENST00000360607.5_Missense_Mutation_p.G165S			O95460	MATN4_HUMAN	matrilin 4	165	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				ATTTCAATGCCGCGGGCGCGC	0.721000													5	22					0	0	1	0	0
IL36RN	26525	broad.mit.edu	37	2	113817030	113817030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113817030G>A	ENST00000393200.2	+	2	176	c.15G>A	c.(13-15)ggG>ggA	p.G5G	IL36RN_ENST00000346807.3_Silent_p.G5G	NM_012275.2	NP_036407.1	Q9UBH0	I36RA_HUMAN	interleukin 36 receptor antagonist	5						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						TCCTGAGTGGGGCGCTGTGCT	0.552000													16	54					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34770216	34770216	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34770216C>T	ENST00000338074.2	+	6	674	c.513C>T	c.(511-513)ttC>ttT	p.F171F	EPB41L1_ENST00000202028.5_Silent_p.F109F|EPB41L1_ENST00000373941.1_Silent_p.F171F|EPB41L1_ENST00000441639.1_Silent_p.F109F|EPB41L1_ENST00000373946.3_Silent_p.F140F|EPB41L1_ENST00000373950.2_Silent_p.F74F	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	171	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					ATTTTGCCTTCACAGTCAAGT	0.577000													27	61					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743149	26743149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26743149G>A	ENST00000396005.3	-	1	422	c.113C>T	c.(112-114)tCc>tTc	p.S38F	SLC5A12_ENST00000280467.6_Missense_Mutation_p.S38F	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	38					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GAACTCTCGGGAAGTTGCCTT	0.498000													80	38					0	0	1	0	0
HSD17B13	345275	broad.mit.edu	37	4	88243952	88243952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88243952G>A	ENST00000328546.4	-	1	106	c.42C>T	c.(40-42)atC>atT	p.I14I	RP11-529H2.2_ENST00000508163.1_RNA|HSD17B13_ENST00000302219.6_Silent_p.I14I	NM_178135.3	NP_835236.2	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	14						extracellular region	binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		AGGAGTAGATGATGGTGATCA	0.468000													19	47					0	0	1	0	0
LRRC2	79442	broad.mit.edu	37	3	46593050	46593050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46593050G>A	ENST00000395905.3	-	2	424	c.32C>T	c.(31-33)tCt>tTt	p.S11F	LRRC2_ENST00000296144.3_Missense_Mutation_p.S11F|LRRC2_ENST00000496388.1_Intron	NM_024512.4	NP_078788.2	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	11										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	17		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		TCTGATGACAGAAATGTCGAA	0.413000													42	90					0	0	1	0	0
CLIP4	79745	broad.mit.edu	37	2	29368177	29368177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29368177G>A	ENST00000320081.5	+	8	1220	c.965G>A	c.(964-966)gGa>gAa	p.G322E	CLIP4_ENST00000401617.2_Missense_Mutation_p.G215E|CLIP4_ENST00000404424.1_Missense_Mutation_p.G322E|CLIP4_ENST00000401605.1_Missense_Mutation_p.G322E	NM_024692.4	NP_078968.3	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family, member 4	322	CAP-Gly 1.									endometrium(4)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(1)	26	Acute lymphoblastic leukemia(172;0.155)					GAACCAGAAGGAAAAAATAAT	0.348000													17	68					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62738910	62738910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62738910C>T	ENST00000371153.4	-	3	2244	c.1866G>A	c.(1864-1866)aaG>aaA	p.K622K	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	622										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CCGGTGGCTCCTTGGGTGGGT	0.607000													23	41					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233348889	233348889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233348889C>T	ENST00000304546.1	-	7	1439	c.1229G>A	c.(1228-1230)aGt>aAt	p.S410N	ECEL1_ENST00000409941.1_Missense_Mutation_p.S410N	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	410					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CAGGTGTTCACTCAGGACCAC	0.647000													7	33					0	0	1	0	0
NOS1AP	9722	broad.mit.edu	37	1	162270444	162270444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:162270444G>A	ENST00000361897.5	+	4	694	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	NOS1AP_ENST00000530878.1_Missense_Mutation_p.E93K	NM_001164757.1|NM_014697.2	NP_001158229.1|NP_055512.1	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	98	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GCAGAAAAAGGAATGGACGTG	0.478000													32	97					0	0	1	0	0
GUCA1C	9626	broad.mit.edu	37	3	108626928	108626928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108626928C>T	ENST00000261047.3	-	4	703	c.571G>A	c.(571-573)Gag>Aag	p.E191K	GUCA1C_ENST00000393963.3_3'UTR	NM_005459.3	NP_005450.3	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	191					signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity			endometrium(2)|large_intestine(1)|liver(1)|lung(8)|pancreas(1)|skin(1)	14						GAGTCTGTCTCCATGTCTGGC	0.463000													4	60					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176947013	176947013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:176947013C>T	ENST00000308618.4	-	2	728	c.592G>A	c.(592-594)Gag>Aag	p.E198K		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	198						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GCGATCTGCTCGCGGGTGAAC	0.711000													4	19					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377343	55377343	+	Missense_Mutation	SNP	C	C	T	rs138402445		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55377343C>T	ENST00000326321.3	+	7	1117	c.1084C>T	c.(1084-1086)Cgc>Tgc	p.R362C	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.R362C|KIR3DL2_ENST00000270442.5_Missense_Mutation_p.R345C	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	362					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		tctcctTTATCGCTGGTGCTC	0.532000													13	43					0	0	1	0	0
DPH6	89978	broad.mit.edu	37	15	35742927	35742927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:35742927G>A	ENST00000256538.4	-	5	490	c.464C>T	c.(463-465)tCa>tTa	p.S155L		NM_080650.3	NP_542381.1			diphthamine biosynthesis 6																		AATGTTAGATGATATCATCTC	0.388000													32	85					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51752006	51752006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51752006C>T	ENST00000543196.2	-	8	1613	c.1408G>A	c.(1408-1410)Gaa>Aaa	p.E470K	GALNT6_ENST00000356317.3_Missense_Mutation_p.E470K			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	470					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TGCAGTTGTTCCCTCAGCTGC	0.463000													48	111					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222713440	222713440	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:222713440G>A	ENST00000343410.6	-	4	1420	c.1362C>T	c.(1360-1362)gaC>gaT	p.D454D		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	454					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		TCAAAATGAGGTCAACCTCTT	0.517000													45	112					0	0	1	0	0
PRODH	5625	broad.mit.edu	37	22	18909852	18909852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18909852G>A	ENST00000357068.6	-	7	1180	c.915C>T	c.(913-915)acC>acT	p.T305T	PRODH_ENST00000420436.1_Silent_p.T197T|PRODH_ENST00000334029.2_Silent_p.T197T	NM_016335.4	NP_057419.4	O43272	PROD_HUMAN	proline dehydrogenase (oxidase) 1	305					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)|endometrium(3)|lung(4)|upper_aerodigestive_tract(1)	9					L-Proline(DB00172)	ACACTCCCAGGGTCTCTGCCG	0.602000													7	31					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81056306	81056306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81056306C>T	ENST00000334512.5	+	13	1881	c.1309C>T	c.(1309-1311)Ccg>Tcg	p.P437S	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	437	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CCCCAACCCCCCGAGGCCACT	0.627000													66	118					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19236122	19236122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19236122C>T	ENST00000562034.1	+	5	4805	c.1007C>T	c.(1006-1008)cCc>cTc	p.P336L	SYT17_ENST00000355377.2_Missense_Mutation_p.P397L|SYT17_ENST00000568433.1_Missense_Mutation_p.P91L|SYT17_ENST00000568115.1_Missense_Mutation_p.P336L|SYT17_ENST00000562711.2_Missense_Mutation_p.P393L			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	397	C2 2.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						TTCAAAGTTCCCCAAGAAGAA	0.453000													24	75					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189612091	189612091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189612091C>T	ENST00000264731.3	+	14	1932	c.1843C>T	c.(1843-1845)Cat>Tat	p.H615Y	TP63_ENST00000449992.1_Missense_Mutation_p.H436Y|TP63_ENST00000440651.2_Missense_Mutation_p.H611Y|TP63_ENST00000320472.5_3'UTR|TP63_ENST00000382063.4_Missense_Mutation_p.H530Y|TP63_ENST00000456148.1_Missense_Mutation_p.H517Y|TP63_ENST00000354600.5_Missense_Mutation_p.H521Y	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	615	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CTCCCCTTCTCATCTCCTGCG	0.572000										HNSCC(45;0.13)			35	73					0	0	1	0	0
LTA4H	4048	broad.mit.edu	37	12	96421285	96421285	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:96421285G>A	ENST00000228740.2	-	3	489	c.348C>T	c.(346-348)ctC>ctT	p.L116L	LTA4H_ENST00000552789.1_Silent_p.L92L|LTA4H_ENST00000413268.2_Silent_p.L92L|RP11-256L6.2_ENST00000547346.1_RNA	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	116					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						TGAGCCACTGGAGAGCAGAAG	0.368000													14	78					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51411603	51411603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:51411603C>T	ENST00000319760.6	-	1	845	c.793G>A	c.(793-795)Gat>Aat	p.D265N		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				ATGAACTTATCAGTAGGAAAG	0.363000													21	73					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30982993	30982993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30982993C>T	ENST00000262519.8	+	13	3997	c.3311C>T	c.(3310-3312)cCa>cTa	p.P1104L		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	1104	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GCAGGCTCCCCAGTCACACCC	0.657000													14	39					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145439619	145439619	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145439619C>T	ENST00000511217.1	+	8	1798	c.1746C>T	c.(1744-1746)ctC>ctT	p.L582L	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Silent_p.L582L			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	582							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCCGCCCTCACGTGCATCA	0.622000													19	70					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50947861	50947861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50947861G>A	ENST00000374103.4	-	17	2250	c.2165C>T	c.(2164-2166)gCc>gTc	p.A722V	OGDHL_ENST00000419399.1_Missense_Mutation_p.A665V|OGDHL_ENST00000432695.1_Missense_Mutation_p.A513V	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	722					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						ATTGGGGCTGGCCATGGCATA	0.562000													17	37					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374045	27374045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27374045C>T	ENST00000395762.2	+	11	1631	c.1372C>T	c.(1372-1374)Ccc>Tcc	p.P458S	IL4R_ENST00000380922.3_Missense_Mutation_p.P443S|IL4R_ENST00000170630.2_Missense_Mutation_p.P458S|IL4R_ENST00000543915.2_Missense_Mutation_p.P458S	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	458	Required for IRS1 activation and IL4- induced cell growth.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GGAGGCACCTCCCTGGGGCAA	0.622000													17	69					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220356557	220356557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220356557G>A	ENST00000312358.7	+	39	9559	c.9427G>A	c.(9427-9429)Gac>Aac	p.D3143N	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	3143	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTCTGCCACGGACATCTGGGG	0.622000													10	27					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15688980	15688980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15688980C>T	ENST00000378076.3	-	12	1425	c.1072G>A	c.(1072-1074)Ggg>Agg	p.G358R		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	358					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TAGATTTGCCCTACTTCTCTG	0.507000													21	64					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8272584	8272584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8272584G>A	ENST00000396267.1	-	2	1932	c.1101C>T	c.(1099-1101)agC>agT	p.S367S	RP11-849F2.7_ENST00000582471.1_3'UTR|RP11-849F2.5_ENST00000583963.1_RNA|KRBA2_ENST00000331336.2_Silent_p.S449S|RP11-849F2.5_ENST00000580537.1_RNA			Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	449	Integrase catalytic.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(5)|stomach(1)|urinary_tract(1)	18						TGATCCAAAGGCTATTTTCTA	0.468000													56	84					0	0	1	0	0
C6orf201	404220	broad.mit.edu	37	6	4087912	4087912	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:4087912C>T	ENST00000380175.4	+	2	802	c.37C>T	c.(37-39)Ctg>Ttg	p.L13L	C6orf201_ENST00000333388.5_Intron|C6orf201_ENST00000360378.6_3'UTR|C6orf201_ENST00000430835.2_Silent_p.L13L	NM_001085401.2	NP_001078870.1	Q7Z4U5	CF201_HUMAN	chromosome 6 open reading frame 201	13										central_nervous_system(1)|endometrium(3)|lung(2)	6	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TCCGAATCACCTGATGGAGAC	0.488000													127	279					0	0	1	0	0
ZC4H2	55906	broad.mit.edu	37	X	64138976	64138976	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:64138976C>T	ENST00000545618.1	-	5	1055	c.492G>A	c.(490-492)agG>agA	p.R164R	ZC4H2_ENST00000374839.3_Silent_p.R169R|ZC4H2_ENST00000447788.2_Intron|ZC4H2_ENST00000337990.2_Silent_p.R146R|ZC4H2_ENST00000488608.1_5'UTR			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	169							metal ion binding|protein binding			endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TATCCTGCTTCCTAGCCACTT	0.597000													32	16					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4966352	4966352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:4966352G>A	ENST00000333703.4	+	5	1213	c.700G>A	c.(700-702)Gat>Aat	p.D234N	PCDH11Y_ENST00000215473.6_Missense_Mutation_p.D245N|PCDH11Y_ENST00000362095.5_Missense_Mutation_p.D245N	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	245	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GGAAGAGAAGGATACCTATGT	0.398000													61	102					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120438859	120438859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120438859G>A	ENST00000369400.1	-	1	259	c.101C>T	c.(100-102)cCt>cTt	p.P34L		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	34					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CTCCCCTTCAGGGTGAAAAAT	0.512000													10	55					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86089439	86089439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:86089439C>T	ENST00000330753.4	+	2	2348	c.1581C>T	c.(1579-1581)tcC>tcT	p.S527S	FLRT2_ENST00000554746.1_Silent_p.S527S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	527					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		ACACAGCGTCCAGCCATGAGC	0.587000													50	129					0	0	1	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307132	39307132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39307132G>A	ENST00000541347.1	-	2	1108	c.869C>T	c.(868-870)cCt>cTt	p.P290L	CX3CR1_ENST00000358309.3_Missense_Mutation_p.P322L|CX3CR1_ENST00000542107.1_Missense_Mutation_p.P290L|CX3CR1_ENST00000399220.2_Missense_Mutation_p.P290L	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	290					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		ATAGATGAGAGGATTCAGGCA	0.498000													41	87					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	432714	432714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:432714G>A	ENST00000256509.2	+	22	3305	c.2663G>A	c.(2662-2664)gGa>gAa	p.G888E	CHL1_ENST00000397491.2_Missense_Mutation_p.G872E	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	872	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGATTTTCAGGACAAAGAAAC	0.363000													31	69					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74708868	74708868	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:74708868G>A	ENST00000308807.7	-	10	1834	c.1371C>T	c.(1369-1371)ccC>ccT	p.P457P	MLKL_ENST00000306247.7_Silent_p.P249P	NM_152649.2	NP_689862.1	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like	457	Protein kinase.						ATP binding|protein binding|protein kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(6)|skin(1)|stomach(2)	19						CATCCACAGAGGGCCGCACAG	0.542000													24	55					0	0	1	0	0
SNORA71B	26776	broad.mit.edu	37	20	37053851	37053851	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:37053851G>A	ENST00000364546.1	-	0	128																											AGGCATGTACGAAAGCTCCAG	0.512000													37	78					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22310748	22310748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22310748C>T	ENST00000337107.6	+	6	585	c.566C>T	c.(565-567)tCc>tTc	p.S189F		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	189	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						GAACACTGCTCCAGGTGGAAC	0.607000													33	61					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3949556	3949556	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3949556G>A	ENST00000281228.8	-	0	653				FAM86EP_ENST00000313946.8_RNA																							GTCACCCTGGGGCCGTCTAAG	0.602000													8	54					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183446550	183446550	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183446550C>G	ENST00000305135.5	+	7	918	c.723C>G	c.(721-723)tcC>tcG	p.S241S		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	241	YEATS.				histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCCGAGGGTCCCGTAGAGAAC	0.413000													10	85					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76149896	76149896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:76149896C>T	ENST00000298832.9	+	5	473	c.268C>T	c.(268-270)Cac>Tac	p.H90Y	TTLL5_ENST00000556977.1_Missense_Mutation_p.H90Y|TTLL5_ENST00000557636.1_Missense_Mutation_p.H90Y|TTLL5_ENST00000286650.5_Missense_Mutation_p.H90Y	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	90	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		CCCTCAGGTTCACCCAAGCAG	0.453000													28	83					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58063569	58063569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:58063569C>T	ENST00000339762.6	-	1	46	c.47G>A	c.(46-48)aGg>aAg	p.R16K	SLC35F4_ENST00000556826.1_Intron|SLC35F4_ENST00000557430.1_Intron|SLC35F4_ENST00000554729.1_5'UTR					solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGCCAGCTGCCTCCCACTGGT	0.413000													13	29					0	0	1	0	0
ANKRD6	22881	broad.mit.edu	37	6	90326361	90326361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:90326361G>A	ENST00000369408.5	+	8	1048	c.699G>A	c.(697-699)acG>acA	p.T233T	ANKRD6_ENST00000485637.1_Silent_p.T233T|ANKRD6_ENST00000522441.1_Silent_p.T233T|ANKRD6_ENST00000520793.1_Silent_p.T200T|ANKRD6_ENST00000339746.4_Silent_p.T233T|ANKRD6_ENST00000447838.2_Silent_p.T233T	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	233			T -> M (in dbSNP:rs2273238).				protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		GAGCAGATACGACCATTGTTA	0.473000													23	36					0	0	1	0	0
PEF1	553115	broad.mit.edu	37	1	32101117	32101117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32101117G>A	ENST00000373703.4	-	2	53	c.31C>T	c.(31-33)Cca>Tca	p.P11S	PEF1_ENST00000492061.1_5'UTR|PEF1_ENST00000440872.2_Missense_Mutation_p.P11S	NM_012392.3	NP_036524.1	Q9UBV8	PEF1_HUMAN	penta-EF-hand domain containing 1	11					response to calcium ion	cytoplasm|membrane	calcium ion binding|protein heterodimerization activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)	7		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)|all_neural(195;0.186)		STAD - Stomach adenocarcinoma(196;0.0546)		GCAGCTCCTGGGCAGCCCTGC	0.567000													8	17					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7611736	7611736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7611736G>A	ENST00000256861.6	-	12	2122	c.2044C>T	c.(2044-2046)Ccc>Tcc	p.P682S	ITIH5_ENST00000397146.2_Intron|ITIH5_ENST00000298441.6_Missense_Mutation_p.P468S|ITIH5_ENST00000446830.2_Missense_Mutation_p.P464S	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	682					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						ACAAAGTGGGGATCACCATCC	0.493000													6	25					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56544947	56544947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56544947C>T	ENST00000390649.3	+	9	2487	c.2487C>T	c.(2485-2487)ctC>ctT	p.L829L		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	829						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGCAGCACCTCTGGAGAATCG	0.488000													65	131					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139636053	139636053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139636053G>A	ENST00000263552.6	+	9	938	c.400G>A	c.(400-402)Gaa>Aaa	p.E134K	TBXAS1_ENST00000425687.1_Missense_Mutation_p.E66K|TBXAS1_ENST00000416849.2_Missense_Mutation_p.E134K|TBXAS1_ENST00000411653.1_Missense_Mutation_p.E133K|TBXAS1_ENST00000414508.2_Missense_Mutation_p.E134K|TBXAS1_ENST00000458722.1_Missense_Mutation_p.E133K|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000336425.5_Missense_Mutation_p.E133K|TBXAS1_ENST00000436047.2_Missense_Mutation_p.E134K|TBXAS1_ENST00000448866.1_Missense_Mutation_p.E133K	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	133					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CAAAAGATGGGAAGAGGTCAG	0.498000													78	180					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203197680	203197680	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203197680G>A	ENST00000367229.1	-	2	70	c.36C>T	c.(34-36)gtC>gtT	p.V12V	CHIT1_ENST00000535569.1_Silent_p.V22V|CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000255427.3_Silent_p.V12V	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	12					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						TCATCAGCAGGACCATGAAAC	0.562000													4	11					0	0	1	0	0
PRPF31	26121	broad.mit.edu	37	19	54626875	54626875	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54626875C>T	ENST00000321030.4	+	6	812	c.463C>T	c.(463-465)Ctg>Ttg	p.L155L	PRPF31_ENST00000391755.1_Silent_p.L155L|PRPF31_ENST00000419967.1_Silent_p.L155L|PRPF31_ENST00000498612.1_3'UTR|AC012314.8_ENST00000452097.1_RNA	NM_015629.3	NP_056444.3	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31	155					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)|urinary_tract(3)	12	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAATGAGAACCTGCAGCAGAT	0.612000													33	106					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776054	5776054	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5776054G>A	ENST00000317254.3	+	1	132	c.84G>A	c.(82-84)tgG>tgA	p.W28*	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CACAACTCTGGATTTCCTTCC	0.438000													27	69					0	0	1	0	0
PURG	29942	broad.mit.edu	37	8	30889533	30889533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30889533C>T	ENST00000475541.1	-	1	1698	c.766G>A	c.(766-768)Gat>Aat	p.D256N	PURG_ENST00000339382.2_Missense_Mutation_p.D256N	NM_013357.2	NP_037489.1	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G	256						nucleus	DNA binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		AGCGGGTCATCGTCTCCACCT	0.453000													26	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604077	179604077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179604077G>A	ENST00000589042.1	-	48	14107	c.13883C>T	c.(13882-13884)tCc>tTc	p.S4628F	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S4265F|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S4457F|TTN_ENST00000359218.5_Missense_Mutation_p.S4390F|TTN_ENST00000591111.1_Missense_Mutation_p.S4311F|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4311	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTGTTATGGATGTTGTGAG	0.388000													7	51					0	0	1	0	0
DNAH14	127602	broad.mit.edu	37	1	225140444	225140444	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:225140444C>T	ENST00000430092.1	+	2	255	c.40C>T	c.(40-42)Caa>Taa	p.Q14*	DNAH14_ENST00000498360.1_3'UTR|DNAH14_ENST00000439375.2_Nonsense_Mutation_p.Q14*|DNAH14_ENST00000366850.3_Nonsense_Mutation_p.Q14*|DNAH14_ENST00000366849.1_Nonsense_Mutation_p.Q14*|DNAH14_ENST00000366848.1_Nonsense_Mutation_p.Q14*|DNAH14_ENST00000400952.3_Nonsense_Mutation_p.Q14*	NM_001373.1	NP_001364.1	Q0VDD8	DYH14_HUMAN	dynein, axonemal, heavy chain 14	191					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(2)|lung(2)|skin(2)|stomach(1)	27						AACTGAAAATCAAGAGATGGA	0.308000													7	21					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45353847	45353847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45353847G>A	ENST00000359271.2	+	2	422	c.172G>A	c.(172-174)Gct>Act	p.A58T		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	58						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				GCTCCTGGGGGCTCTCCTCGC	0.607000													15	43					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168104111	168104111	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168104111G>A	ENST00000409195.1	+	9	6298	c.6209G>A	c.(6208-6210)gGa>gAa	p.G2070E	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.G2070E|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.G1848E	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1895					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATACTACAGGAGAACAGCAT	0.378000													13	76					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087032	92087032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92087032G>A	ENST00000298047.6	+	1	1771	c.1754G>A	c.(1753-1755)gGa>gAa	p.G585E	FAT3_ENST00000541502.1_Missense_Mutation_p.G585E|FAT3_ENST00000409404.2_Missense_Mutation_p.G585E|FAT3_ENST00000525166.1_Missense_Mutation_p.G435E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	585	Cadherin 6.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTTGCCAGGGAGTTATTTCA	0.428000										TCGA Ovarian(4;0.039)			14	29					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157772251	157772251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157772251C>T	ENST00000358292.3	-	4	574	c.523G>A	c.(523-525)Gag>Aag	p.E175K	FCRL1_ENST00000491942.1_Missense_Mutation_p.E175K|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000368176.3_Missense_Mutation_p.E175K	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	175	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity	p.E175*(2)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GCATCACTCTCCCTCACTGAA	0.488000													28	72					0	0	1	0	0
PGBD5	79605	broad.mit.edu	37	1	230492691	230492691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230492691G>A	ENST00000321327.2	-	4	797	c.798C>T	c.(796-798)ctC>ctT	p.L266L	PGBD5_ENST00000391860.1_Silent_p.L121L|PGBD5_ENST00000525115.1_Silent_p.L167L			Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	167						integral to membrane				biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(2)|skin(1)	33	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		GCAGGGAGTCGAGGAAGGGCT	0.612000													20	67					0	0	1	0	0
SULT1C4	27233	broad.mit.edu	37	2	108998259	108998259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108998259G>A	ENST00000272452.2	+	2	537	c.211G>A	c.(211-213)Gaa>Aaa	p.E71K	SULT1C4_ENST00000409309.3_Missense_Mutation_p.E71K	NM_006588.2	NP_006579.2	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member 4	71					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						AATACAAAATGAAGGTGATGT	0.378000													20	51					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156476087	156476087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156476087C>T	ENST00000339252.3	-	4	1275	c.743G>A	c.(742-744)aGa>aAa	p.R248K	HAVCR1_ENST00000425854.1_Missense_Mutation_p.R248K|HAVCR1_ENST00000544197.1_Missense_Mutation_p.R248K|HAVCR1_ENST00000517644.1_5'UTR|HAVCR1_ENST00000522693.1_Missense_Mutation_p.R248K|HAVCR1_ENST00000523175.1_Missense_Mutation_p.R248K	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	243					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGGGTTCTCTCCTTATTGC	0.463000													39	86					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15132675	15132675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15132675C>T	ENST00000292574.3	+	6	1277	c.1195C>T	c.(1195-1197)Cgc>Tgc	p.R399C		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	399					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						ACCCCTGGTTCGCATGTACCA	0.637000													33	58					0	0	1	0	0
IFNA6	3443	broad.mit.edu	37	9	21350466	21350466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21350466G>A	ENST00000380210.1	-	1	911	c.421C>T	c.(421-423)Ctg>Ttg	p.L141L		NM_021002.2	NP_066282.1	P05013	IFNA6_HUMAN	interferon, alpha 6	141					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			large_intestine(3)|lung(7)|skin(1)	11				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		CTCACAGCCAGGATGGAGTCC	0.493000													46	335					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491646	100491646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100491646C>T	ENST00000302913.4	-	2	346	c.208G>A	c.(208-210)Gag>Aag	p.E70K	ACHE_ENST00000411582.1_Missense_Mutation_p.E70K|ACHE_ENST00000241069.5_Missense_Mutation_p.E70K|ACHE_ENST00000428317.1_Missense_Mutation_p.E70K|ACHE_ENST00000412389.1_Missense_Mutation_p.E70K|ACHE_ENST00000419336.2_Missense_Mutation_p.E70K	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	70					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	ATGGGTGGCTCCGCAAAGGGG	0.652000													8	24					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111195317	111195317	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:111195317G>A	ENST00000262839.2	-	2	1250	c.332C>T	c.(331-333)gCt>gTt	p.A111V		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	111					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAGCTCCACAGCGCCCACCAC	0.542000													17	74					0	0	1	0	0
ZNF317	57693	broad.mit.edu	37	19	9271434	9271434	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9271434C>T	ENST00000247956.6	+	7	1418	c.1113C>T	c.(1111-1113)ttC>ttT	p.F371F	ZNF317_ENST00000360385.3_Silent_p.F339F	NM_020933.4	NP_065984.3	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	27						GCAAAGCCTTCCGCTGGAAGT	0.537000													9	27					0	0	1	0	0
ABCC6P1	653190	broad.mit.edu	37	16	18603886	18603886	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:18603886C>T	ENST00000546162.2	+	0	1229					NR_003569.1																						TATTGGTGATCCCAAGCCTCC	0.562000													13	19					0	0	1	0	0
CNNM3	26505	broad.mit.edu	37	2	97494389	97494389	+	Nonsense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97494389T>G	ENST00000305510.3	+	6	1900	c.1872T>G	c.(1870-1872)taT>taG	p.Y624*	CNNM3_ENST00000377060.3_Nonsense_Mutation_p.Y576*|CNNM3_ENST00000480035.1_3'UTR|ANKRD23_ENST00000476975.1_Intron	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	624					ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						CATCTGCGTATTGTCCCGACT	0.592000													23	35					0	0	1	0	0
SLC29A3	55315	broad.mit.edu	37	10	73122030	73122030	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73122030C>T	ENST00000373189.5	+	6	1145	c.1093C>T	c.(1093-1095)Ctc>Ttc	p.L365F	SLC29A3_ENST00000469204.1_3'UTR	NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	365					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						TGGCCGGCAGCTCACCGCCTG	0.592000													66	208					0	0	1	0	0
GEMIN7	79760	broad.mit.edu	37	19	45593555	45593555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45593555C>T	ENST00000270257.4	+	3	430	c.183C>T	c.(181-183)gcC>gcT	p.A61A	CTB-179K24.3_ENST00000586556.1_RNA|GEMIN7_ENST00000591747.1_Silent_p.A61A|GEMIN7_ENST00000391951.2_Silent_p.A61A|GEMIN7_ENST00000591607.1_Silent_p.A61A|CTB-179K24.4_ENST00000586744.1_RNA	NM_001007269.1|NM_001007270.1|NM_024707.2	NP_001007270.1|NP_001007271.1|NP_078983.1	Q9H840	GEMI7_HUMAN	gem (nuclear organelle) associated protein 7	61					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			endometrium(1)|kidney(1)|lung(4)|ovary(1)	7		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		CACGAGCCGCCCTTCGGGAGC	0.627000													8	44					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207307839	207307839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207307839G>A	ENST00000367070.3	+	9	1369	c.1175G>A	c.(1174-1176)gGa>gAa	p.G392E		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	392	Sushi 6.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TATTTCTATGGAGATGAGATT	0.423000													43	133					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61940042	61940042	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61940042G>A	ENST00000422202.1	+	7	1013	c.945G>A	c.(943-945)gtG>gtA	p.V315V	COL20A1_ENST00000326996.6_Silent_p.V308V|COL20A1_ENST00000435874.1_Silent_p.V315V|COL20A1_ENST00000358894.6_Silent_p.V308V			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	308	VWFA.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					ACCTGGGCGTGAACGTCTTCG	0.657000													8	8					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17122442	17122442	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17122442G>A	ENST00000443236.1	-	4	565	c.534C>T	c.(532-534)ttC>ttT	p.F178F	CTD-2528A14.1_ENST00000595134.1_RNA|CPAMD8_ENST00000388925.4_Silent_p.F131F	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	131						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CCGTCTGGATGAATACAGAAG	0.657000													44	113					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52264053	52264053	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:52264053G>A	ENST00000354831.7	-	24	2865	c.2676C>T	c.(2674-2676)gcC>gcT	p.A892A	NRD1_ENST00000539524.1_Silent_p.A760A|RP4-657D16.3_ENST00000586761.1_RNA|RP4-657D16.3_ENST00000588291.1_RNA|RP4-657D16.3_ENST00000591675.1_RNA|NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000544028.1_Silent_p.A692A|NRD1_ENST00000352171.7_Silent_p.A824A	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	823					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TAGACCAACGGGCATATTCCA	0.403000													28	65					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51243806	51243806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51243806G>A	ENST00000245441.5	-	7	717	c.527C>T	c.(526-528)tCt>tTt	p.S176F	NIN_ENST00000530997.2_Missense_Mutation_p.S176F|NIN_ENST00000389868.3_Missense_Mutation_p.S176F|NIN_ENST00000324330.9_Missense_Mutation_p.S176F|NIN_ENST00000382041.3_Missense_Mutation_p.S176F|NIN_ENST00000382043.4_Missense_Mutation_p.S176F|NIN_ENST00000453196.1_Missense_Mutation_p.S176F	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	176					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					GGGAGGGGAAGATCCACTCTG	0.478000			T	PDGFRB	MPD								26	85					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175097744	175097744	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175097744C>T	ENST00000239462.4	+	15	3305	c.3192C>T	c.(3190-3192)ttC>ttT	p.F1064F		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1064	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GTGCCCGTTTCCCACACCCTT	0.537000													31	80					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47432807	47432807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47432807C>T	ENST00000285039.7	-	19	2695	c.2396G>A	c.(2395-2397)cGg>cAg	p.R799Q		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	799	IQ 2.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CAGGTGTCCCCGGCAGTACCT	0.582000													7	51					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36170723	36170723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:36170723G>A	ENST00000335119.2	+	1	1335	c.1224G>A	c.(1222-1224)aaG>aaA	p.K408K		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	408					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			TGGCAGGAAAGATGAGCATCC	0.547000													28	68					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18643341	18643341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:18643341G>A	ENST00000379989.3	+	18	2755	c.2470G>A	c.(2470-2472)Gag>Aag	p.E824K	CDKL5_ENST00000379996.3_Missense_Mutation_p.E824K	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	824					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					GTGGCGCCCCGAGAAGATCTC	0.547000													66	42					0	0	1	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103601679	103601679	+	Silent	SNP	C	C	T	rs146608837	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103601679C>T	ENST00000560869.1	+	12	2586	c.1947C>T	c.(1945-1947)tcC>tcT	p.S649S	TNFAIP2_ENST00000538222.1_Silent_p.S132S|TNFAIP2_ENST00000451723.2_Silent_p.S318S|TNFAIP2_ENST00000333007.1_Silent_p.S649S			Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	649					angiogenesis|cell differentiation	extracellular space				NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	11		Melanoma(154;0.155)	Epithelial(46;0.191)			CCCTATTTTCCCTTATAAAGG	0.597000													97	215					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123970966	123970966	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123970966G>A	ENST00000369005.1	+	9	7366	c.7026G>A	c.(7024-7026)tgG>tgA	p.W2342*	TACC2_ENST00000334433.3_Nonsense_Mutation_p.W2342*|TACC2_ENST00000358010.1_Nonsense_Mutation_p.W488*|TACC2_ENST00000369004.3_Nonsense_Mutation_p.W420*|TACC2_ENST00000513429.1_Nonsense_Mutation_p.W488*|TACC2_ENST00000369001.1_Nonsense_Mutation_p.W46*|TACC2_ENST00000369000.1_Nonsense_Mutation_p.W46*|TACC2_ENST00000515603.1_Nonsense_Mutation_p.W2297*|TACC2_ENST00000360561.3_Nonsense_Mutation_p.W420*|TACC2_ENST00000368999.1_Nonsense_Mutation_p.W420*|TACC2_ENST00000260733.3_Nonsense_Mutation_p.W420*|TACC2_ENST00000515273.1_Nonsense_Mutation_p.W2346*|TACC2_ENST00000453444.2_Nonsense_Mutation_p.W2346*	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2342	SPAZ.					microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTGACAAGTGGGATGACCCCA	0.463000													111	248					0	0	1	0	0
HIST1H3F	8968	broad.mit.edu	37	6	26250518	26250518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26250518C>T	ENST00000446824.2	-	1	317	c.316G>A	c.(316-318)Gag>Aag	p.E106K		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	106					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			lung(6)|urinary_tract(1)	7						TTGGTGTCCTCAAAGAGCCCC	0.602000											OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	147					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3658802	3658802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:3658802G>A	ENST00000404826.2	+	2	528	c.389G>A	c.(388-390)gGg>gAg	p.G130E	SDK1_ENST00000389531.3_Missense_Mutation_p.G130E	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	130	Ig-like C2-type 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CTTGCCGAAGGGAGCTGGCCT	0.478000													9	53					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30973981	30973981	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:30973981G>A	ENST00000295055.8	-	11	1400	c.1224C>T	c.(1222-1224)ttC>ttT	p.F408F	CAPN13_ENST00000534090.2_Silent_p.F408F	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	408					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GAATCACTTGGAAATCGAGTG	0.473000													9	17					0	0	1	0	0
THSD1	55901	broad.mit.edu	37	13	52952628	52952628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52952628C>T	ENST00000349258.4	-	4	1862	c.1318G>A	c.(1318-1320)Ggc>Agc	p.G440S	THSD1_ENST00000258613.4_Missense_Mutation_p.G493S|THSD1_ENST00000544466.1_Missense_Mutation_p.G114S	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	493						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		AGAGGGATGCCTGTGTCCCCT	0.647000													21	69					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18436239	18436239	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:18436239G>A	ENST00000338745.6	-	7	2655	c.921C>T	c.(919-921)ctC>ctT	p.L307L	SATB1_ENST00000454909.2_Silent_p.L307L|SATB1_ENST00000417717.2_Silent_p.L307L|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	307					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						GTGTTGATACGAGCCCAGGGT	0.572000													22	99					0	0	1	0	0
TECTB	6975	broad.mit.edu	37	10	114061871	114061871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:114061871C>T	ENST00000369422.3	+	9	920	c.920C>T	c.(919-921)tCc>tTc	p.S307F	TECTB_ENST00000494328.1_3'UTR	NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	307						anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		AGGGGATTTTCCAGTCTCTAT	0.403000													49	112					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170103479	170103479	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170103479G>A	ENST00000263816.3	-	21	3211	c.2926C>T	c.(2926-2928)Caa>Taa	p.Q976*	LRP2_ENST00000443831.1_Nonsense_Mutation_p.Q839*	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	976	EGF-like 4.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGCGTGGGTTGATTACAGGCG	0.502000													8	34					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406335	55406335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55406335G>A	ENST00000314612.2	+	1	502	c.502G>A	c.(502-504)Ggc>Agc	p.G168S		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						ACCATTTTGTGGCCCAAATGA	0.388000													29	66					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39229826	39229826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39229826C>T	ENST00000340369.3	-	2	1339	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.E371K	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	371							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		ACCACTTCCTCCTTGGGTGGG	0.582000													72	177					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183944265	183944265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183944265C>T	ENST00000361927.4	-	3	829	c.458G>A	c.(457-459)cGa>cAa	p.R153Q	COLGALT2_ENST00000546159.1_Missense_Mutation_p.R153Q	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2									p.R153Q(1)									CCTCGCAGTTCGAAGGGCTGC	0.423000													32	86					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179437688	179437688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179437688G>A	ENST00000367618.3	+	17	2296	c.1909G>A	c.(1909-1911)Gaa>Aaa	p.E637K	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	637										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GGAAATAGATGAAAAAATTAA	0.353000													29	67					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157665230	157665230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157665230C>T	ENST00000368184.3	-	8	1591	c.1300G>A	c.(1300-1302)Gga>Aga	p.G434R	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Missense_Mutation_p.G434R|RP11-367J7.3_ENST00000453692.1_RNA	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	434	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AAGGAGGCTCCTCCTCCAGAG	0.562000													45	150					0	0	1	0	0
PPT1	5538	broad.mit.edu	37	1	40555169	40555169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40555169G>A	ENST00000433473.3	-	5	913	c.449C>T	c.(448-450)cCt>cTt	p.P150L	PPT1_ENST00000449045.2_Missense_Mutation_p.P47L	NM_000310.3	NP_000301.1	P50897	PPT1_HUMAN	palmitoyl-protein thioesterase 1	150					brain development|cofactor metabolic process|cofactor transport|DNA fragmentation involved in apoptotic nuclear change|lysosomal lumen acidification|membrane raft organization|negative regulation of cell growth|negative regulation of neuron apoptosis|neuron development|pinocytosis|positive regulation of pinocytosis|positive regulation of receptor-mediated endocytosis|protein depalmitoylation|protein transport|receptor-mediated endocytosis|regulation of synapse structure and activity|sphingolipid catabolic process|visual perception	axon|cytosol|Golgi apparatus|lysosome|membrane fraction|membrane raft|nucleus|synaptic vesicle	palmitoyl-(protein) hydrolase activity|palmitoyl-CoA hydrolase activity	p.P150H(1)		endometrium(5)|large_intestine(1)|lung(3)|ovary(1)|stomach(1)	11	Lung NSC(20;3.43e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1e-18)|Epithelial(16;3.6e-17)|all cancers(16;1.1e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGGGCATCGAGGGAGTCCAAA	0.443000													18	68					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29390737	29390737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:29390737C>T	ENST00000558402.1	+	10	1895	c.1296C>T	c.(1294-1296)ttC>ttT	p.F432F	APBA2_ENST00000558259.1_Silent_p.F432F|APBA2_ENST00000561069.1_Silent_p.F432F|APBA2_ENST00000411764.1_Silent_p.F420F|APBA2_ENST00000558330.1_Silent_p.F420F			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	432	PID.				nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TGGACCTCTTCATTTCCACCC	0.443000													19	62					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21730468	21730468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21730468G>A	ENST00000328843.6	+	36	6062	c.6031G>A	c.(6031-6033)Gaa>Aaa	p.E2011K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E2004K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2011	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGGTCGAACCGAATTACCGGA	0.413000									Kartagener syndrome				31	195					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1734100	1734100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1734100C>T	ENST00000381241.3	+	1	207	c.8C>T	c.(7-9)tCc>tTc	p.S3F	ASMT_ENST00000381233.3_Missense_Mutation_p.S3F|ASMT_ENST00000381229.4_Missense_Mutation_p.S3F	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	3					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AAGATGGGATCCTCAGAGGAC	0.592000													5	10					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187840	152187840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152187840C>T	ENST00000368801.2	-	3	6340	c.6265G>A	c.(6265-6267)Ggt>Agt	p.G2089S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2089					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAAGACCGACCGGAGCCAGAC	0.622000													45	121					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87615822	87615822	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87615822C>T	ENST00000327946.7	-	7	1162	c.1077G>A	c.(1075-1077)tgG>tgA	p.W359*		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	359						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCCCACCATTCCATGGCTTAG	0.552000										Multiple Myeloma(13;0.14)			10	98					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168175434	168175434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168175434C>T	ENST00000519560.1	-	20	2562	c.2143G>A	c.(2143-2145)Gag>Aag	p.E715K	SLIT3_ENST00000332966.8_Missense_Mutation_p.E715K|SLIT3_ENST00000404867.3_Missense_Mutation_p.E715K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	715					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTACTCTCCTCGTTGCCTGTG	0.632000													8	49					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19544092	19544092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:19544092C>T	ENST00000507958.1	-	11	2266	c.1276G>A	c.(1276-1278)Gaa>Aaa	p.E426K	CDH18_ENST00000382275.1_Missense_Mutation_p.E426K|CDH18_ENST00000274170.4_Missense_Mutation_p.E426K|CDH18_ENST00000502796.1_Missense_Mutation_p.E426K|CDH18_ENST00000511273.1_Missense_Mutation_p.E426K|CDH18_ENST00000506372.1_Missense_Mutation_p.E426K			Q13634	CAD18_HUMAN	cadherin 18, type 2	426	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTGTCGTCTTCAACATTGTAG	0.343000													26	33					0	0	1	0	0
PKIA	5569	broad.mit.edu	37	8	79513998	79513998	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:79513998G>A	ENST00000396418.2	+	4	659	c.173G>A	c.(172-174)cGa>cAa	p.R58Q	PKIA_ENST00000518467.1_Missense_Mutation_p.R58Q|PKIA_ENST00000352966.5_Missense_Mutation_p.R58Q	NM_006823.3|NM_181839.2	NP_006814.1|NP_862822.1	P61925	IPKA_HUMAN	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	58							cAMP-dependent protein kinase inhibitor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	6						GATGCACAACGAAGTTCTACA	0.388000													7	31					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20676384	20676384	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20676384G>A	ENST00000525748.1	+	16	2637	c.2364G>A	c.(2362-2364)gtG>gtA	p.V788V	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	788					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	AACTGCCAGTGAAGGATTTGG	0.532000													64	143					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30318780	30318780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30318780G>A	ENST00000375377.1	-	3	398	c.297C>T	c.(295-297)ccC>ccT	p.P99P		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	99										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ATGCTGAGGGGGGTTGATTAC	0.512000													6	33					0	0	1	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032136	46032136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46032136C>T	ENST00000334662.2	+	1	141	c.119C>T	c.(118-120)tCc>tTc	p.S40F	TSPEAR_ENST00000323084.4_Intron	NM_198695.2	NP_941968.2	P60410	KR108_HUMAN	keratin associated protein 10-8	40	19 X 5 AA repeats of C-C-X(3).					keratin filament				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	17						ACTGGCTCCTCCTGGCAGGTG	0.642000													15	109					0	0	1	0	0
CSF3	1440	broad.mit.edu	37	17	38172548	38172548	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38172548C>T	ENST00000331769.2	+	2	462	c.246C>T	c.(244-246)atC>atT	p.I82I	CSF3_ENST00000394149.3_Silent_p.I86I|CSF3_ENST00000225474.2_Silent_p.I89I|CSF3_ENST00000394148.3_Intron|CSF3_ENST00000577675.1_Intron			P09919	CSF3_HUMAN	colony stimulating factor 3 (granulocyte)	89					cytokine-mediated signaling pathway|granulocyte differentiation|immune response|positive regulation of cell proliferation	extracellular space	cytokine activity|enzyme binding|granulocyte colony-stimulating factor receptor binding|growth factor activity			endometrium(1)|ovary(1)|prostate(1)	3	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CTCTGGGCATCCCCTGGGCTC	0.627000													5	5					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584424	1584424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1584424C>T	ENST00000381297.4	-	2	1238	c.1028G>A	c.(1027-1029)gGg>gAg	p.G343E		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	343						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCCCTCCATCCCTTCAGGGTG	0.711000			T	CRLF2	"""B-ALL, Downs associated ALL"""								33	81					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41142988	41142988	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41142988C>T	ENST00000263413.3	-	18	3008	c.2744G>A	c.(2743-2745)gGa>gAa	p.G915E	C6_ENST00000337836.5_Missense_Mutation_p.G915E	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	915	C5b-binding domain.|Complement control factor I module 2.|Kazal-like 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCTTATAGTTCCCACTTCACA	0.438000													30	72					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281792	152281792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152281792C>T	ENST00000368799.1	-	3	5605	c.5570G>A	c.(5569-5571)gGg>gAg	p.G1857E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1857	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGACTGCCCACGGGAGAC	0.542000									Ichthyosis				164	478					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313098	54313098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54313098G>A	ENST00000324134.6	-	3	1983	c.1815C>T	c.(1813-1815)acC>acT	p.T605T	NLRP12_ENST00000391772.1_Silent_p.T605T|NLRP12_ENST00000535162.1_Silent_p.T605T|NLRP12_ENST00000391773.1_Silent_p.T605T|NLRP12_ENST00000354278.3_Silent_p.T605T|NLRP12_ENST00000391775.3_Silent_p.T605T|NLRP12_ENST00000351894.4_Silent_p.T605T|NLRP12_ENST00000345770.5_Silent_p.T605T	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	605					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCTGCTGCAGGGTGGAGCCGT	0.577000													25	81					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97658696	97658696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:97658696C>T	ENST00000370192.3	-	20	2651	c.2551G>A	c.(2551-2553)Gga>Aga	p.G851R	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	851					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GGACTCTGTCCATCCCAGTCT	0.448000													32	62					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776262	5776262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5776262G>A	ENST00000317254.3	+	1	340	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TGGATTTGATGAATGCCTTGT	0.488000													25	78					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58036612	58036612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:58036612G>A	ENST00000556826.1	-	6	1256	c.1020C>T	c.(1018-1020)ttC>ttT	p.F340F	SLC35F4_ENST00000339762.6_Silent_p.F376F|SLC35F4_ENST00000554729.1_Silent_p.F217F	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGAAGGAGATGAAGATCAAAT	0.483000													4	12					0	0	1	0	0
DLL3	10683	broad.mit.edu	37	19	39998532	39998532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39998532C>T	ENST00000205143.4	+	8	1743	c.1736C>T	c.(1735-1737)gCt>gTt	p.A579V	DLL3_ENST00000356433.5_Missense_Mutation_p.A579V	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	579					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTCATATCTGCTCCTTCCATC	0.547000													17	58					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56203125	56203125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56203125C>T	ENST00000361673.3	-	5	4507	c.4294G>A	c.(4294-4296)Gaa>Aaa	p.E1432K	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1432							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TGACCCCCTTCTCTGGCGCCC	0.512000													17	91					0	0	1	0	0
IRF6	3664	broad.mit.edu	37	1	209961966	209961966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209961966C>T	ENST00000367021.3	-	9	1375	c.1203G>A	c.(1201-1203)atG>atA	p.M401I	IRF6_ENST00000542854.1_Missense_Mutation_p.M306I	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	401					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TCTCGTAGATCATCCGAGCCA	0.453000										HNSCC(57;0.16)			4	22					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71634886	71634886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71634886G>A	ENST00000356340.3	+	4	938	c.402G>A	c.(400-402)ggG>ggA	p.G134G	COL13A1_ENST00000398968.3_Silent_p.G134G|COL13A1_ENST00000520133.1_Intron|COL13A1_ENST00000398966.3_Silent_p.G134G|COL13A1_ENST00000398969.3_Intron|COL13A1_ENST00000398974.3_Intron|COL13A1_ENST00000398972.3_Silent_p.G134G|COL13A1_ENST00000398973.3_Silent_p.G134G|COL13A1_ENST00000398971.3_Silent_p.G134G|COL13A1_ENST00000520267.1_Intron|COL13A1_ENST00000398964.3_Intron|COL13A1_ENST00000357811.3_Silent_p.G134G|COL13A1_ENST00000354547.3_Silent_p.G134G|COL13A1_ENST00000517713.1_Silent_p.G134G|COL13A1_ENST00000522165.1_Silent_p.G134G|COL13A1_ENST00000398978.3_Silent_p.G134G			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	134	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	ATCATCAGGGGGACAAAGGTG	0.547000													12	33					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3322099	3322099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3322099C>T	ENST00000378398.3	+	9	1158	c.1076C>T	c.(1075-1077)tCg>tTg	p.S359L	PRDM16_ENST00000378391.2_Missense_Mutation_p.S358L|PRDM16_ENST00000270722.5_Missense_Mutation_p.S358L|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Missense_Mutation_p.S358L|PRDM16_ENST00000441472.2_Missense_Mutation_p.S358L|PRDM16_ENST00000514189.1_Missense_Mutation_p.S359L|PRDM16_ENST00000511072.1_Missense_Mutation_p.S359L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	358					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CACATCCGCTCGCAGCACGTG	0.682000			T	EVI1	"""MDS, AML"""								19	57					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105451060	105451060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105451060G>A	ENST00000337685.2	+	5	2420	c.1635G>A	c.(1633-1635)atG>atA	p.M545I	MUM1L1_ENST00000372552.1_Missense_Mutation_p.M545I|MUM1L1_ENST00000357175.2_Missense_Mutation_p.M545I	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	545										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						CTGACCGGATGAAGGCTGCTC	0.468000													9	9					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115220557	115220557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115220557C>T	ENST00000369538.3	-	8	1332	c.1285G>A	c.(1285-1287)Ggg>Agg	p.G429R	AMPD1_ENST00000353928.6_Missense_Mutation_p.G400R|AMPD1_ENST00000520113.2_Missense_Mutation_p.G433R	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	400					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AAATATTCCCCATTAATGTAA	0.433000													19	148					0	0	1	0	0
CLDN6	9074	broad.mit.edu	37	16	3065728	3065728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3065728G>A	ENST00000396925.1	-	3	723	c.295C>T	c.(295-297)Ctt>Ttt	p.L99F	CLDN6_ENST00000328796.4_Missense_Mutation_p.L99F|CLDN6_ENST00000572154.1_Intron			P56747	CLD6_HUMAN	claudin 6	99					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GCCCCAGCAAGGTAGACCAGC	0.612000													16	45					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1246138	1246138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1246138C>T	ENST00000324642.3	+	12	1955	c.1832C>T	c.(1831-1833)cCg>cTg	p.P611L		NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	611					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GACATGCGCCCGGACACGGAC	0.746000													4	8					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480155	73480155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73480155G>A	ENST00000523207.1	+	2	774	c.186G>A	c.(184-186)ggG>ggA	p.G62G		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	62					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CGCGCCTGGGGAAGCTTCGAG	0.552000													23	105					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79092829	79092829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79092829C>T	ENST00000388820.4	-	2	371	c.161G>A	c.(160-162)gGg>gAg	p.G54E	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	54					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GAAGGAGCCCCCCGCGTCGAC	0.672000													6	12					0	0	1	0	0
NRSN1	140767	broad.mit.edu	37	6	24134672	24134672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24134672C>T	ENST00000378491.4	+	3	418	c.117C>T	c.(115-117)gcC>gcT	p.A39A	NRSN1_ENST00000378478.1_Silent_p.A39A|NRSN1_ENST00000378475.1_Silent_p.A39A	NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	39					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						ACTGTACAGCCTCAATTTGGG	0.507000													28	51					0	0	1	0	0
CLPSL1	340204	broad.mit.edu	37	6	35754847	35754847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35754847G>A	ENST00000373861.5	+	2	266	c.172G>A	c.(172-174)Gag>Aag	p.E58K	CLPSL1_ENST00000542261.1_Missense_Mutation_p.E57K			A2RUU4	CF127_HUMAN	colipase-like 1	58					digestion|lipid catabolic process	extracellular region	enzyme activator activity										AGACAATTGCGAGTCGCACTG	0.657000													3	21					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766216	77766216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77766216G>A	ENST00000521891.2	+	10	7507	c.7059G>A	c.(7057-7059)atG>atA	p.M2353I	ZFHX4_ENST00000050961.6_Missense_Mutation_p.M2308I|ZFHX4_ENST00000455469.2_Missense_Mutation_p.M2308I|ZFHX4_ENST00000518282.1_Missense_Mutation_p.M2327I	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2308	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAGACTCCATGGATGCCACTG	0.473000										HNSCC(33;0.089)			42	118					0	0	1	0	0
THOC6	79228	broad.mit.edu	37	16	3077236	3077236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3077236C>T	ENST00000326266.8	+	11	1061	c.765C>T	c.(763-765)ttC>ttT	p.F255F	THOC6_ENST00000574549.1_Silent_p.F231F|THOC6_ENST00000575576.1_Silent_p.F231F|THOC6_ENST00000253952.9_Silent_p.F255F	NM_024339.3	NP_077315.2	Q86W42	THOC6_HUMAN	THO complex 6 homolog (Drosophila)	255					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	13						CCACCATCTTCCCCATCCGGG	0.632000													25	93					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111432842	111432842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111432842C>T	ENST00000393934.3	+	3	1303	c.733C>T	c.(733-735)Ctc>Ttc	p.L245F	PLCXD2_ENST00000472215.1_3'UTR|PLCXD2_ENST00000477665.1_Missense_Mutation_p.L245F	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	245					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CAAACTAATCCTCTTCTTGGA	0.567000													32	72					0	0	1	0	0
PRB3	5544	broad.mit.edu	37	12	11420567	11420567	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11420567C>T	ENST00000381842.3	-	0	642				PRB3_ENST00000279573.6_RNA|PRB3_ENST00000538488.1_RNA|PRB3_ENST00000440870.3_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGGGGTGGTCCTTCTGGCTTT	0.632000													30	400					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37486341	37486341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37486341C>T	ENST00000374660.1	+	35	2937	c.2838C>T	c.(2836-2838)gcC>gcT	p.A946A	ANKRD30A_ENST00000602533.1_Silent_p.A827A|ANKRD30A_ENST00000361713.1_Silent_p.A827A			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	997						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TTTAGCCTGCCATTGAAATGC	0.308000													37	104					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202538	56202538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56202538C>T	ENST00000361673.3	-	5	5094	c.4881G>A	c.(4879-4881)atG>atA	p.M1627I		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1627							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TAGGTTCCTCCATTTTGTGGC	0.458000													24	86					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200971323	200971323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200971323C>T	ENST00000332129.2	-	9	1684	c.1368G>A	c.(1366-1368)atG>atA	p.M456I	KIF21B_ENST00000461742.2_Missense_Mutation_p.M456I|KIF21B_ENST00000360529.5_Missense_Mutation_p.M456I|KIF21B_ENST00000422435.2_Missense_Mutation_p.M456I	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	456					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CCTCCTGGCTCATGAGCTGGG	0.627000													27	58					0	0	1	0	0
TMPO	7112	broad.mit.edu	37	12	98941610	98941610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:98941610C>T	ENST00000556029.1	+	9	1695	c.1339C>T	c.(1339-1341)Cat>Tat	p.H447Y	TMPO_ENST00000548223.1_3'UTR|TMPO_ENST00000393053.2_Missense_Mutation_p.H338Y|TMPO_ENST00000343315.5_Missense_Mutation_p.H407Y	NM_001032283.2	NP_001027454.1	P42167	LAP2B_HUMAN	thymopoietin	447						integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TAATTTTCTTCATGTTGACCC	0.343000													51	115					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70956739	70956739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70956739G>A	ENST00000334414.6	-	16	4097	c.4053C>T	c.(4051-4053)gaC>gaT	p.D1351D	PTPRB_ENST00000550857.1_Silent_p.D1043D|PTPRB_ENST00000451516.2_Silent_p.D1043D|PTPRB_ENST00000551525.1_Silent_p.D1350D|PTPRB_ENST00000550358.1_Silent_p.D1263D|PTPRB_ENST00000538708.1_Silent_p.D1043D|PTPRB_ENST00000261266.5_Silent_p.D1133D	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1133	Fibronectin type-III 15.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGACTAGTGGGTCAACTTGAG	0.498000													17	75					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98189325	98189325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98189325G>A	ENST00000332650.5	+	1	1002	c.905G>A	c.(904-906)aGa>aAa	p.R302K		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGTGTCTTAAGAAAAATTCTG	0.294000													14	46					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111748289	111748289	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111748289A>T	ENST00000261726.6	+	15	1857	c.1703A>T	c.(1702-1704)aAa>aTa	p.K568I		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	568						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CAGCTGCTGAAACACAACATC	0.687000													35	80					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987912	50987912	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50987912C>T	ENST00000395676.2	+	1	1451	c.1317C>T	c.(1315-1317)ttC>ttT	p.F439F		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	439										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGGCACCTTCCCTGTGGCCC	0.652000													28	85					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11706749	11706749	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11706749T>C	ENST00000381486.2	+	4	721	c.421T>C	c.(421-423)Ttg>Ctg	p.L141L	GREB1_ENST00000389825.3_Silent_p.L31L|GREB1_ENST00000234142.5_Silent_p.L141L|GREB1_ENST00000263834.5_Silent_p.L141L|GREB1_ENST00000381483.2_Silent_p.L141L	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	141						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CAAGAGGTTCTTGCCAGATGA	0.577000													42	105					0	0	1	0	0
SLC16A11	162515	broad.mit.edu	37	17	6945458	6945458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6945458G>A	ENST00000308009.1	-	3	1380	c.1043C>T	c.(1042-1044)gCc>gTc	p.A348V	SLC16A11_ENST00000447225.1_Missense_Mutation_p.A316V	NM_153357.1	NP_699188.1	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	348						integral to membrane|plasma membrane	symporter activity			endometrium(2)|kidney(2)|lung(2)|ovary(1)|skin(2)	9						CAGCCCATAGGCCACAGCCGC	0.716000													7	5					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167786700	167786700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:167786700C>T	ENST00000397829.4	-	8	1105	c.938G>A	c.(937-939)gGa>gAa	p.G313E	TCP10_ENST00000366827.2_Intron	NM_004610.3	NP_004601.3	Q12799	TCP10_HUMAN	t-complex 10	340						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		GTGCAGAGCTCCTGGAAATTC	0.527000													12	92					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72667227	72667227	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72667227G>A	ENST00000261180.4	+	1	765	c.669G>A	c.(667-669)agG>agA	p.R223R	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	223					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TGCTGAATAGGACACTGGACG	0.557000													17	84					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27361019	27361019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27361019G>A	ENST00000335524.3	-	3	704	c.179C>T	c.(178-180)tCc>tTc	p.S60F		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	60	Pro-rich.									cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGAGGGGAGGAGGGACGACG	0.572000													7	28					0	0	1	0	0
SRSF11	9295	broad.mit.edu	37	1	70716379	70716379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70716379C>T	ENST00000370950.3	+	13	1428	c.1346C>T	c.(1345-1347)tCc>tTc	p.S449F	SRSF11_ENST00000370949.1_Missense_Mutation_p.S389F|SRSF11_ENST00000405432.1_Missense_Mutation_p.S449F|SRSF11_ENST00000370951.1_Missense_Mutation_p.S448F|SRSF11_ENST00000484162.1_3'UTR			Q05519	SRS11_HUMAN	serine/arginine-rich splicing factor 11	449					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			large_intestine(3)|ovary(2)|skin(1)	6						GAAACAGGTTCCCCTAAAACA	0.408000													11	69					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6711196	6711196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6711196C>T	ENST00000245907.6	-	12	1373	c.1281G>A	c.(1279-1281)aaG>aaA	p.K427K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	427					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GCTCCTGCTTCTTCGTGCGCA	0.607000													12	51					0	0	1	0	0
MSGN1	343930	broad.mit.edu	37	2	17997965	17997965	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:17997965C>T	ENST00000281047.3	+	1	203	c.180C>T	c.(178-180)ccC>ccT	p.P60P		NM_001105569.1	NP_001099039.1	A6NI15	MSGN1_HUMAN	mesogenin 1	60					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTTCTTCTCCCTGTCCAGCTG	0.657000													8	90					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56481389	56481389	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56481389G>A	ENST00000370765.6	-	24	6983	c.6876C>T	c.(6874-6876)ttC>ttT	p.F2292F	DST_ENST00000361203.3_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000244364.6_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1630					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGGGATTAGGGAAAACTCTTG	0.423000													39	88					0	0	1	0	0
TRGV8	6982	broad.mit.edu	37	7	38370508	38370508	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38370508G>A	ENST00000390343.2	-	0	28																											ACTCAACAAGGAAGTGATCCC	0.512000													9	24					0	0	1	0	0
IL20	50604	broad.mit.edu	37	1	207041867	207041867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207041867G>A	ENST00000367098.1	+	6	852	c.489G>A	c.(487-489)ggG>ggA	p.G163G	IL20_ENST00000367096.3_Silent_p.G163G|IL20_ENST00000391930.2_Silent_p.G138G			Q9NYY1	IL20_HUMAN	interleukin 20	163					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding			endometrium(2)|large_intestine(3)|lung(2)|pancreas(1)|urinary_tract(1)	9	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		AGGCTTTGGGGGAACTAGACA	0.473000													7	22					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46263989	46263989	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46263989G>A	ENST00000510861.1	-	9	1186	c.1013C>T	c.(1012-1014)aCc>aTc	p.T338I	GABRA2_ENST00000507069.1_Missense_Mutation_p.T338I|GABRA2_ENST00000356504.1_Missense_Mutation_p.T338I|GABRA2_ENST00000515082.1_Missense_Mutation_p.T338I|GABRA2_ENST00000381620.4_Missense_Mutation_p.T338I|GABRA2_ENST00000540012.1_Missense_Mutation_p.T283I|GABRA2_ENST00000514090.1_Missense_Mutation_p.T338I			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	338					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCCTCTTTTGGTGAAGTAATT	0.398000													34	108					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55838615	55838615	+	Missense_Mutation	SNP	G	G	A	rs79362849		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:55838615G>A	ENST00000302000.6	-	3	960	c.866C>T	c.(865-867)tCa>tTa	p.S289L	PYGO1_ENST00000563719.1_Missense_Mutation_p.S289L	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	289	Asn-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		AGTGCTACTTGAACGGCTGTT	0.423000													69	347					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47608979	47608979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47608979G>A	ENST00000371891.3	+	5	580	c.549G>A	c.(547-549)ctG>ctA	p.L183L	CYP4A22_ENST00000485117.1_3'UTR|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000371890.3_Silent_p.L183L|CYP4A22_ENST00000294337.3_Silent_p.L183L	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	183						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATTCCCCTCTGGAGGTCTTTC	0.547000													25	63					0	0	1	0	0
SLC5A3	6526	broad.mit.edu	37	21	35469468	35469468	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:35469468C>T	ENST00000381151.3	+	2	2483	c.1971C>T	c.(1969-1971)ttC>ttT	p.F657F	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	657						integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						ACTGGAAGTTCATAGACTGGT	0.463000													11	135					0	0	1	0	0
TIAL1	7073	broad.mit.edu	37	10	121336989	121336989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:121336989G>A	ENST00000369092.4	-	10	1650	c.342C>T	c.(340-342)ttC>ttT	p.F114F	TIAL1_ENST00000369093.2_Silent_p.F254F|TIAL1_ENST00000436547.2_Silent_p.F237F			Q01085	TIAR_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein-like 1	237	RRM 2.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(3)|ovary(1)	13		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		CCTTTTCTGGGAAAACTCTTA	0.318000													28	48					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81969958	81969958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81969958G>A	ENST00000359376.3	+	27	3241	c.3027G>A	c.(3025-3027)atG>atA	p.M1009I		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	1009	PI-PLC Y-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						GTTCTCAGATGGTGGCACTCA	0.567000													18	62					0	0	1	0	0
NEXN	91624	broad.mit.edu	37	1	78383885	78383885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:78383885G>A	ENST00000330010.8	+	4	479	c.182G>A	c.(181-183)cGa>cAa	p.R61Q	NEXN_ENST00000334785.7_Missense_Mutation_p.R125Q|NEXN_ENST00000457030.1_Missense_Mutation_p.R125Q|NEXN_ENST00000294624.8_Missense_Mutation_p.R125Q	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	125	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		GAGGAGGAACGAAAACGCAGA	0.363000													35	83					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154862651	154862651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:154862651C>T	ENST00000287907.2	+	1	618	c.42C>T	c.(40-42)acC>acT	p.T14T	AC093726.4_ENST00000395731.2_Intron|AC093726.4_ENST00000543018.1_Intron|AC093726.4_ENST00000493904.1_Intron	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	14						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CCCTCTCCACCCCCTCCCCTT	0.587000													49	131					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131519752	131519752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131519752C>T	ENST00000423981.1	+	2	217	c.107C>T	c.(106-108)cCc>cTc	p.P36L	AMER3_ENST00000321420.4_Missense_Mutation_p.P36L	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GGGACAGGCCCCTGGTCAGTC	0.622000													3	10					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46825075	46825075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46825075C>T	ENST00000339613.2	+	10	1274	c.1019C>T	c.(1018-1020)tCc>tTc	p.S340F	HIF3A_ENST00000244303.6_Missense_Mutation_p.S327F|HIF3A_ENST00000420102.2_Missense_Mutation_p.S345F|AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000600383.1_Missense_Mutation_p.S327F|HIF3A_ENST00000472815.1_Missense_Mutation_p.S327F|HIF3A_ENST00000300862.3_Missense_Mutation_p.S394F|HIF3A_ENST00000377670.4_Missense_Mutation_p.S396F			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CACCCGCCTTCCCTGAGCGAG	0.687000													21	101					0	0	1	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420022	56420022	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:56420022G>A	ENST00000407595.2	+	2	1189	c.687G>A	c.(685-687)gcG>gcA	p.A229A	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	229	His-rich.									breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AGCACCACGCGAGCAGTGGCA	0.682000													20	45					0	0	1	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79629673	79629673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:79629673C>T	ENST00000263849.4	+	9	1025	c.923C>T	c.(922-924)cCt>cTt	p.P308L		NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	308																	ACTAAATACCCTGTAGAATGG	0.368000													59	132					0	0	1	0	0
NDUFA9	4704	broad.mit.edu	37	12	4796131	4796131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4796131C>T	ENST00000266544.5	+	11	1011	c.991C>T	c.(991-993)Cac>Tac	p.H331Y	NDUFA9_ENST00000540688.1_Missense_Mutation_p.H90Y|RP11-234B24.6_ENST00000544741.2_Intron	NM_005002.4	NP_004993.1	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa	331					mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21					NADH(DB00157)	GAAATTGCCTCACCTGCCTGG	0.502000													15	33					0	0	1	0	0
ERRFI1	54206	broad.mit.edu	37	1	8073739	8073739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8073739G>A	ENST00000377482.5	-	4	1143	c.920C>T	c.(919-921)tCg>tTg	p.S307L	ERRFI1_ENST00000474874.1_Intron|ERRFI1_ENST00000467067.1_3'UTR	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	307					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		ATAGGTGCTCGAAGTAACTTC	0.507000													58	137					0	0	1	0	0
TUBG1	7283	broad.mit.edu	37	17	40766576	40766576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40766576C>T	ENST00000251413.3	+	10	1121	c.1059C>T	c.(1057-1059)ccC>ccT	p.P353P		NM_001070.4	NP_001061.2	P23258	TBG1_HUMAN	tubulin, gamma 1	353					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		CGTGGGGCCCCGCCAGCATCC	0.652000													40	40					0	0	1	0	0
RASD2	23551	broad.mit.edu	37	22	35947969	35947969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:35947969G>A	ENST00000216127.4	+	3	1333	c.691G>A	c.(691-693)Gtc>Atc	p.V231I		NM_014310.3	NP_055125.2	Q96D21	RHES_HUMAN	RASD family, member 2	231	Interaction with GNB1, GNB2 and GNB3.				locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	13						CTATGGCATGGTCTCGCCCTT	0.647000													18	53					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102709863	102709863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102709863C>T	ENST00000299855.5	-	7	1303	c.1047G>A	c.(1045-1047)aaG>aaA	p.K349K		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	349	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	AAACGAGGTCCTTGCTAGTAA	0.373000													52	74					0	0	1	0	0
ADD3	120	broad.mit.edu	37	10	111872536	111872536	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:111872536C>T	ENST00000277900.8	+	3	562	c.195_splice	c.e3-1	p.A66_splice	ADD3_ENST00000497125.1_3'UTR|ADD3_ENST00000356080.4_Splice_Site_p.A66_splice|ADD3_ENST00000360162.3_Splice_Site_p.A66_splice	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	66						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GTATTACAGGCCTTTCGGGAA	0.403000													33	92					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48745180	48745180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48745180G>A	ENST00000427699.1	+	12	1777	c.1697G>A	c.(1696-1698)aGg>aAg	p.R566K	ABCC3_ENST00000285238.8_Intron	NM_001144070.1	NP_001137542.1	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	0	ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GGCATGGCCAGGGCTCATTGG	0.622000													7	24					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113286461	113286461	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113286461C>T	ENST00000264852.4	+	3	1145	c.419C>T	c.(418-420)cCc>cTc	p.P140L	SIDT1_ENST00000393830.3_Missense_Mutation_p.P140L	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	140						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						GAGACGGGACCCTTGCAGCAA	0.493000													50	153					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111109730	111109730	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111109730C>T	ENST00000360467.5	+	21	1686	c.1380C>T	c.(1378-1380)ggC>ggT	p.G460G	COL4A2-AS2_ENST00000458403.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	460	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GAAGAGCAGGCTTCCCTGGGC	0.617000													11	42					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11468641	11468641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:11468641G>A	ENST00000423059.3	-	14	3427	c.3176C>T	c.(3175-3177)tCt>tTt	p.S1059F	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1059	TSP type-1 11.					integral to membrane		p.S1059F(1)		NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CAGCCATTTAGAACGAACCTT	0.507000										HNSCC(18;0.044)			97	284					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73065742	73065742	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73065742C>T	ENST00000429829.1	-	0	6846					NR_001564.2																						GAAAAGGGGCCTTGGTGATCA	0.512000													49	45					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13612089	13612089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13612089C>T	ENST00000404922.3	+	2	353	c.234C>T	c.(232-234)ttC>ttT	p.F78F	FBLN2_ENST00000295760.7_Silent_p.F78F|FBLN2_ENST00000535798.1_Silent_p.F104F|FBLN2_ENST00000492059.1_Silent_p.F78F	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	78	N.|Subdomain NA (Cys-rich).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGGGTGGCTTCGTGCGCGGCC	0.657000													3	7					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30433000	30433000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30433000G>A	ENST00000375978.3	-	1	420	c.346C>T	c.(346-348)Cgg>Tgg	p.R116W		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	116					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CCTGTCTGCCGGGTGAAGCGG	0.706000													10	32					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17743770	17743770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:17743770G>A	ENST00000380060.3	+	6	1819	c.1481G>A	c.(1480-1482)gGg>gAg	p.G494E	NHS_ENST00000398097.3_Missense_Mutation_p.G338E	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	494						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					AATAGAGGTGGGGATGCTGAG	0.512000													22	42					0	0	1	0	0
OR7C1	26664	broad.mit.edu	37	19	14910058	14910058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14910058C>T	ENST00000248073.2	-	1	965	c.891G>A	c.(889-891)atG>atA	p.M297I	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	297					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						GGGCCCTCTTCATGTCCGTGT	0.522000													43	96					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44131741	44131741	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44131741C>T	ENST00000262726.7	-	7	893	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	EFCAB6_ENST00000396231.2_Missense_Mutation_p.E62K|EFCAB6_ENST00000358439.4_Missense_Mutation_p.E108K|EFCAB6_ENST00000356087.4_Missense_Mutation_p.E108K	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GCTTACTTTTCGTATTCCTCG	0.443000													41	107					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494093	55494093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55494093G>A	ENST00000543010.1	+	6	1170	c.1027G>A	c.(1027-1029)Gac>Aac	p.D343N	NLRP2_ENST00000263437.6_Missense_Mutation_p.D340N|NLRP2_ENST00000537859.1_Missense_Mutation_p.D321N|NLRP2_ENST00000391721.4_Missense_Mutation_p.D319N|NLRP2_ENST00000448584.2_Missense_Mutation_p.D343N|NLRP2_ENST00000339757.7_Missense_Mutation_p.D321N|NLRP2_ENST00000538819.1_Missense_Mutation_p.D319N|NLRP2_ENST00000427260.2_Missense_Mutation_p.D320N	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	343	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGCCCTGAGGGACCTCCGGAT	0.627000													13	15					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347554	91347554	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91347554G>A	ENST00000358859.2	-	1	1399	c.966C>T	c.(964-966)gtC>gtT	p.V322V	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		cagcctcttcgacctcttctt	0.557000													9	31					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25257389	25257389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25257389G>A	ENST00000354454.3	+	19	1970	c.1141G>A	c.(1141-1143)Gaa>Aaa	p.E381K	LRMP_ENST00000547044.1_Missense_Mutation_p.E381K|LRMP_ENST00000548766.1_Missense_Mutation_p.E381K	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	437					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					AGAAAAATGTGAACTAAAGTA	0.403000													7	41					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70501234	70501234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70501234G>A	ENST00000260128.4	+	8	1309	c.592G>A	c.(592-594)Gag>Aag	p.E198K	SULF1_ENST00000458141.2_Missense_Mutation_p.E198K|SULF1_ENST00000419716.3_Missense_Mutation_p.E198K|SULF1_ENST00000402687.4_Missense_Mutation_p.E198K	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	198					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding	p.E198K(1)		breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AATCACTAACGAGAGCATTAA	0.428000													18	73					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112693694	112693694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112693694G>A	ENST00000471858.1	-	1	243	c.11C>T	c.(10-12)cCt>cTt	p.P4L	CD200R1_ENST00000490004.1_Missense_Mutation_p.P4L|CD200R1_ENST00000308611.3_Missense_Mutation_p.P4L|CD200R1_ENST00000440122.2_Missense_Mutation_p.P4L|CD200R1_ENST00000295863.4_Missense_Mutation_p.P4L	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	4					interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						AGTTCTCCAAGGGCAGAGCAT	0.463000													9	48					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77282723	77282723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77282723G>A	ENST00000376896.2	+	8	1629	c.1017G>A	c.(1015-1017)gtG>gtA	p.V339V	RORB_ENST00000396204.2_Silent_p.V350V	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	350	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.V339V(1)		breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						ATGACCTAGTGAATGAAGCAT	0.383000													33	72					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14287146	14287146	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:14287146G>A	ENST00000310358.7	+	0	2872				RP11-21L19.1_ENST00000534587.1_RNA			Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AACGTTACATGACTGTAAAGA	0.473000													15	20					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76490701	76490701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76490701G>A	ENST00000389840.5	-	40	6326	c.6202C>T	c.(6202-6204)Cgg>Tgg	p.R2068W	DNAH17_ENST00000585328.1_Missense_Mutation_p.R2077W|RP11-559N14.5_ENST00000591373.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCCGTTTCCGAGGCACGTCC	0.592000													40	139					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345121	20345121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20345121G>A	ENST00000298642.2	+	1	731	c.695G>A	c.(694-696)gGa>gAa	p.G232E		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTCCAGAGGATCATCTAAG	0.383000													56	142					0	0	1	0	0
TTLL2	83887	broad.mit.edu	37	6	167754787	167754787	+	Missense_Mutation	SNP	G	G	A	rs140708449		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:167754787G>A	ENST00000239587.5	+	3	1487	c.1399G>A	c.(1399-1401)Gag>Aag	p.E467K		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	467					protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		AATGTACAACGAGGATGACTC	0.498000													33	50					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43822140	43822140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43822140C>T	ENST00000389420.3	-	26	3848	c.3849G>A	c.(3847-3849)acG>acA	p.T1283T	ADAMTS20_ENST00000395541.2_Silent_p.T401T|ADAMTS20_ENST00000553158.1_Silent_p.T1283T	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1283						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ATGGCAAATTCGTGCTTAGAT	0.483000													14	50					0	0	1	0	0
LRRC23	10233	broad.mit.edu	37	12	7014914	7014914	+	Silent	SNP	C	C	T	rs116430099	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7014914C>T	ENST00000007969.8	+	2	337	c.117C>T	c.(115-117)ttC>ttT	p.F39F	LRRC23_ENST00000433346.1_Silent_p.F39F|LRRC23_ENST00000443597.2_Silent_p.F39F|LRRC23_ENST00000429740.1_Silent_p.F39F|LRRC23_ENST00000436789.1_Silent_p.F39F|LRRC23_ENST00000323702.5_Silent_p.F39F|LRRC23_ENST00000449039.1_3'UTR	NM_001135217.1|NM_201650.2	NP_001128689.1|NP_964013.1	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	39										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						gggaagagTTCCCTGAGGAAG	0.557000													20	51					0	0	1	0	0
TNFSF18	8995	broad.mit.edu	37	1	173013100	173013100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173013100C>T	ENST00000404377.3	-	2	232	c.232G>A	c.(232-234)Gag>Aag	p.E78K	TNFSF18_ENST00000239468.2_Missense_Mutation_p.E56K|RP1-15D23.2_ENST00000432694.1_RNA	NM_005092.3	NP_005083.2	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily, member 18	78					anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	9						ATACAGGGCTCCTTAGCAGTC	0.353000													39	78					0	0	1	0	0
EHBP1	23301	broad.mit.edu	37	2	63085637	63085637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:63085637C>T	ENST00000263991.5	+	8	1213	c.731C>T	c.(730-732)tCc>tTc	p.S244F	EHBP1_ENST00000354487.3_Intron|EHBP1_ENST00000405289.1_Intron|EHBP1_ENST00000405015.3_Intron|EHBP1_ENST00000431489.1_Intron	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	244						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TCAGCCAGTTCCTCTGAAGGT	0.408000													12	56					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154379625	154379625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:154379625G>A	ENST00000406326.1	+	6	1296	c.893G>A	c.(892-894)gGa>gAa	p.G298E	DPP6_ENST00000332007.3_Intron|DPP6_ENST00000427557.1_Intron|DPP6_ENST00000404039.1_Intron|DPP6_ENST00000377770.3_Intron			P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	0					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGAGTCCCAGGAGGCAGGACT	0.572000													31	127					0	0	1	0	0
MIR1269A	100302177	broad.mit.edu	37	4	67142634	67142634	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:67142634C>T	ENST00000408636.1	+	0	93					NR_031673.1																						tactggcttccctggtctcca	0.517000													6	36					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93518142	93518142	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93518142A>T	ENST00000394196.4	+	20	3607	c.2539A>T	c.(2539-2541)Aaa>Taa	p.K847*	CHD2_ENST00000557381.1_Nonsense_Mutation_p.K847*	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	847	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AGAAATCCGAAAACAGGCACT	0.438000													27	90					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45821601	45821601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45821601C>T	ENST00000397928.1	+	16	2804	c.2359C>T	c.(2359-2361)Cgc>Tgc	p.R787C	TRPM2_ENST00000397932.2_Missense_Mutation_p.R787C|TRPM2_ENST00000300482.5_Missense_Mutation_p.R787C|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.R767C	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	787						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCCCGCGGCCCGCGCCCGTGC	0.652000													39	95					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23219402	23219402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23219402C>T	ENST00000400191.3	+	7	1472	c.1454C>T	c.(1453-1455)gCc>gTc	p.A485V	EPHB2_ENST00000374627.1_Missense_Mutation_p.A480V|EPHB2_ENST00000465676.1_3'UTR|EPHB2_ENST00000374630.3_Missense_Mutation_p.A485V|EPHB2_ENST00000374632.3_Missense_Mutation_p.A485V	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	485	Fibronectin type-III 2.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		AACGCCACAGCCATAAAAAGC	0.602000													26	53					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	20884243	20884243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20884243G>A	ENST00000382152.2	-	2	318	c.151C>T	c.(151-153)Cct>Tct	p.P51S	KCNIP4_ENST00000509207.1_Intron|KCNIP4_ENST00000382149.4_Intron|KCNIP4_ENST00000447367.2_Intron|KCNIP4_ENST00000382150.4_Intron|KCNIP4_ENST00000359001.5_Intron|KCNIP4_ENST00000382148.3_Intron	NM_025221.5	NP_079497.2	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	51						plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				TGAATAGCAGGAGACGACGTT	0.443000													7	53					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155646	151155646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151155646G>A	ENST00000282466.3	-	6	6702	c.6703C>T	c.(6703-6705)Cca>Tca	p.P2235S	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2235	Ig-like C2-type 9.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTGATTAATGGAGGTTTAGAG	0.433000													44	108					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75065478	75065478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75065478C>T	ENST00000326665.5	-	11	1845	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.E346K	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	543	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GTTTCACTCTCTTTTTCAGGG	0.408000													53	225					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2796226	2796226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2796226C>T	ENST00000520002.1	-	71	11134	c.10579G>A	c.(10579-10581)Gaa>Aaa	p.E3527K	CSMD1_ENST00000542608.1_Missense_Mutation_p.E3349K|CSMD1_ENST00000537824.1_Missense_Mutation_p.E3526K|CSMD1_ENST00000602723.1_Missense_Mutation_p.E3350K|CSMD1_ENST00000400186.3_Missense_Mutation_p.E3350K|CSMD1_ENST00000602557.1_Missense_Mutation_p.E3527K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3527						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTGCTGTTTTCATGCCCAGCA	0.403000													3	14					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133984069	133984069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133984069G>A	ENST00000220616.4	+	33	6046	c.6006G>A	c.(6004-6006)gcG>gcA	p.A2002A	TG_ENST00000377869.1_Silent_p.A1945A|TG_ENST00000519543.1_Silent_p.A156A|TG_ENST00000542445.1_Silent_p.A372A	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2002					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGTGCGATGCGGACCCATGCT	0.493000													17	64					0	0	1	0	0
SCNN1D	6339	broad.mit.edu	37	1	1222349	1222349	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1222349C>T	ENST00000338555.2	+	5	1765	c.621C>T	c.(619-621)ttC>ttT	p.F207F	SCNN1D_ENST00000379116.5_Silent_p.F371F|SCNN1D_ENST00000400928.3_Silent_p.F207F|SCNN1D_ENST00000325425.8_Silent_p.F273F					sodium channel, non-voltage-gated 1, delta subunit											lung(6)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GAGTGGGGTTCAGACTGGTGA	0.706000													16	36					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23543653	23543653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23543653C>T	ENST00000300619.7	-	4	2333	c.2128G>A	c.(2128-2130)Gga>Aga	p.G710R	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.G678R	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	710						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGTTTCTCTCCAGCATGTATT	0.318000													13	71					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8720369	8720369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:8720369G>A	ENST00000359865.3	+	4	374	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	SOGA2_ENST00000517570.1_Missense_Mutation_p.E78K|SOGA2_ENST00000400050.3_Missense_Mutation_p.E78K|SOGA2_ENST00000306329.11_Missense_Mutation_p.E438K|SOGA2_ENST00000306285.7_5'UTR	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	429								p.E78K(1)									ATTGCACCACGAACTTAAGAC	0.463000													26	76					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42231185	42231185	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42231185G>A	ENST00000221992.6	+	9	2172	c.2058G>A	c.(2056-2058)ggG>ggA	p.G686G	CEACAM5_ENST00000398599.4_Silent_p.G685G|CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Silent_p.G686G	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	686						anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TCTCAGCTGGGGCCACTGTCG	0.483000													150	386					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121498412	121498412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121498412C>T	ENST00000260197.7	+	47	6642	c.6513C>T	c.(6511-6513)gcC>gcT	p.A2171A	SORL1_ENST00000534286.1_Silent_p.A1081A|SORL1_ENST00000525532.1_Silent_p.A1115A|SORL1_ENST00000532694.1_Silent_p.A1017A|SORL1_ENST00000527934.1_Silent_p.A786A	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2171					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GCTTCACCGCCTTCGCCAACA	0.607000													14	37					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122839956	122839956	+	Silent	SNP	G	G	A	rs145044274		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122839956G>A	ENST00000194130.2	-	1	84	c.45C>T	c.(43-45)ttC>ttT	p.F15F		NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	15						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TGAAAACCACGAAGAGAAATC	0.428000													16	48					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226496869	226496869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226496869G>A	ENST00000328205.5	-	1	565	c.20C>T	c.(19-21)cCt>cTt	p.P7L	LIN9_ENST00000481685.1_Missense_Mutation_p.P7L|LIN9_ENST00000366801.1_5'UTR	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	0	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		CTTTTTCAAAGGCTGCCCGCC	0.672000													22	42					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129123158	129123158	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129123158C>T	ENST00000505956.1	-	7	1500	c.1338G>A	c.(1336-1338)aaG>aaA	p.K446K	EFCAB12_ENST00000326085.3_Silent_p.K446K	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		GAGAAAAGACCTTCCAGTCAG	0.572000													38	87					0	0	1	0	0
RIBC2	26150	broad.mit.edu	37	22	45813553	45813553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45813553C>T	ENST00000342894.3	+	3	478	c.64C>T	c.(64-66)Ctc>Ttc	p.L22F	RIBC2_ENST00000538017.1_Missense_Mutation_p.L90F			Q9H4K1	RIBC2_HUMAN	RIB43A domain with coiled-coils 2	22										NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|skin(2)|urinary_tract(1)	10		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TAGGAAAAATCTCTGTAGGGC	0.433000													18	60					0	0	1	0	0
CKLF	51192	broad.mit.edu	37	16	66599833	66599833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66599833C>T	ENST00000264001.4	+	4	527	c.378C>T	c.(376-378)gcC>gcT	p.A126A	CKLF_ENST00000362093.4_Silent_p.A41A|CKLF_ENST00000417030.2_Intron|CKLF_ENST00000563092.1_3'UTR|CKLF_ENST00000532838.1_Intron|CKLF_ENST00000351137.4_Silent_p.A73A|CKLF_ENST00000345436.4_Silent_p.A94A|CKLF-CMTM1_ENST00000527729.1_Intron	NM_016951.3	NP_058647.1			chemokine-like factor											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|upper_aerodigestive_tract(1)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0689)|Epithelial(162;0.217)		CCGACGGGGCCCTTATTTACC	0.438000													28	114					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34646010	34646010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34646010C>T	ENST00000537011.1	+	5	1394	c.1012C>T	c.(1012-1014)Cct>Tct	p.P338S	NUTM1_ENST00000438749.3_Missense_Mutation_p.P328S|NUTM1_ENST00000333756.4_Missense_Mutation_p.P310S					NUT midline carcinoma, family member 1																		GGGCCTGTCTCCTGCAACCCC	0.552000													38	85					0	0	1	0	0
LINC00842	643650	broad.mit.edu	37	10	47133601	47133601	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:47133601G>A	ENST00000422732.2	-	0	435					NR_033957.1																						ccaccaccacgactgccacca	0.483000													13	82					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189864086	189864086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189864086C>T	ENST00000304636.3	+	30	2268	c.2098C>T	c.(2098-2100)Ccc>Tcc	p.P700S	COL3A1_ENST00000317840.5_Missense_Mutation_p.P700S	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	700	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGAGCTGGTCCCCCTGGTCC	0.478000													4	16					0	0	1	0	0
RD3	343035	broad.mit.edu	37	1	211654713	211654713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:211654713C>T	ENST00000367002.4	-	2	1208	c.45G>A	c.(43-45)cgG>cgA	p.R15R	RD3_ENST00000484910.1_Intron	NM_001164688.1|NM_183059.2	NP_001158160.1|NP_898882.1	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	15					response to stimulus|visual perception					central_nervous_system(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		TGGTGGACAGCCGGGATGGGG	0.622000													8	72					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5363817	5363817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5363817C>T	ENST00000300773.2	-	1	992	c.938G>A	c.(937-939)tGa>tAa	p.*313*	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTGGAGATCAGGTTCCAAT	0.383000													7	71					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513213	78513213	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:78513213C>T	ENST00000397909.2	+	15	3410	c.3237C>T	c.(3235-3237)atC>atT	p.I1079I	NAV3_ENST00000266692.7_Silent_p.I1079I|NAV3_ENST00000536525.2_Silent_p.I1079I|NAV3_ENST00000228327.6_Silent_p.I1079I			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1079	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CTGCCATGATCACCAGCAGTG	0.498000										HNSCC(70;0.22)			6	72					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183888435	183888435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183888435C>T	ENST00000313143.3	+	15	2291	c.2043C>T	c.(2041-2043)gcC>gcT	p.A681A	EIF2B5_ENST00000444495.1_Intron|DVL3_ENST00000431765.1_Silent_p.A664A	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	681					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CCCCAGGAGCCCCTCCGGGCC	0.697000													15	19					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768756	117768756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117768756G>A	ENST00000317775.6	-	2	804	c.119C>T	c.(118-120)cCc>cTc	p.P40L	NOS1_ENST00000344089.3_Missense_Mutation_p.P40L|NOS1_ENST00000338101.4_Missense_Mutation_p.P40L	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	40	Interaction with NOSIP (By similarity).|PDZ.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GATGATCACGGGCGGCTTACT	0.587000													15	78					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1272354	1272354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1272354G>A	ENST00000310581.5	-	7	2385	c.2328C>T	c.(2326-2328)ttC>ttT	p.F776F	TERT_ENST00000296820.5_Intron|TERT_ENST00000508104.2_Intron|TERT_ENST00000334602.6_Silent_p.F776F	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	776	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGTGAGCCACGAACTGTCGCA	0.657000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				6	16					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135862086	135862086	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135862086G>A	ENST00000339463.3	+	6	840	c.21G>A	c.(19-21)gtG>gtA	p.V7V	GFI1B_ENST00000372124.1_Silent_p.V7V|GFI1B_ENST00000372123.1_Silent_p.V7V|GFI1B_ENST00000372122.1_Silent_p.V7V|GFI1B_ENST00000450530.1_Silent_p.V7V|GFI1B_ENST00000534944.1_Silent_p.V7V			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	7	Mediates repression of transcription.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		CCTTCCTGGTGAAGAGCAAGA	0.602000													7	20					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565172	20565172	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20565172C>T	ENST00000329697.6	-	5	835	c.667G>A	c.(667-669)Ggg>Agg	p.G223R	ACSM2B_ENST00000565232.1_Missense_Mutation_p.G223R|ACSM2B_ENST00000565322.1_Missense_Mutation_p.G144R|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G223R	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	223					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CCACTGGTCCCACTAGTGAAG	0.507000													16	85					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15931994	15931994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15931994G>A	ENST00000338282.6	-	2	222	c.116C>T	c.(115-117)cCc>cTc	p.P39L	MYH11_ENST00000300036.5_Missense_Mutation_p.P39L|MYH11_ENST00000452625.2_Missense_Mutation_p.P39L|MYH11_ENST00000396324.3_Missense_Mutation_p.P39L|MYH11_ENST00000576790.1_Missense_Mutation_p.P39L	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	39	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTTCTCCGAGGGGACCCAGAC	0.572000			T	CBFB	AML								23	142					0	0	1	0	0
SLC25A21	89874	broad.mit.edu	37	14	37180580	37180580	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:37180580G>A	ENST00000331299.5	-	7	1061	c.546C>T	c.(544-546)ttC>ttT	p.F182F	SLC25A21_ENST00000555449.1_Silent_p.F182F	NM_030631.3	NP_085134.1	Q9BQT8	ODC_HUMAN	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	182					lysine catabolic process	integral to membrane|mitochondrial inner membrane	alpha-ketoglutarate transmembrane transporter activity|binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|pancreas(1)|prostate(1)|skin(1)	9	Esophageal squamous(585;0.164)|Breast(36;0.179)|Hepatocellular(127;0.213)		Lung(8;2.16e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.0112)|all cancers(34;0.0274)|LUSC - Lung squamous cell carcinoma(13;0.149)	GBM - Glioblastoma multiforme(112;0.00204)		AAACCATGTTGAAAACTCCAT	0.383000													27	59					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13182884	13182884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13182884G>A	ENST00000379350.1	+	6	759	c.630G>A	c.(628-630)gaG>gaA	p.E210E	PHACTR1_ENST00000379345.2_Silent_p.E65E|PHACTR1_ENST00000457702.2_Silent_p.E65E|PHACTR1_ENST00000332995.7_Silent_p.E210E			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	210						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GCTCATATGAGGTGCTCCAAC	0.592000													7	94					0	0	1	0	0
SACM1L	22908	broad.mit.edu	37	3	45773594	45773594	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45773594C>T	ENST00000389061.5	+	13	1255	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	SACM1L_ENST00000541314.1_Nonsense_Mutation_p.R290*|SACM1L_ENST00000418611.1_Nonsense_Mutation_p.R248*	NM_014016.3	NP_054735.3	Q9NTJ5	SAC1_HUMAN	SAC1 suppressor of actin mutations 1-like (yeast)	351	SAC.					Golgi apparatus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		GAGATGGGATCGACTAAGTAT	0.338000													47	133					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32370911	32370911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32370911G>A	ENST00000454136.3	-	3	514	c.510C>T	c.(508-510)ttC>ttT	p.F170F	BTNL2_ENST00000414363.1_Intron|BTNL2_ENST00000540315.1_Intron|BTNL2_ENST00000374993.1_Silent_p.F170F|BTNL2_ENST00000429232.2_Intron|BTNL2_ENST00000374995.3_Intron|BTNL2_ENST00000544175.1_Intron			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	170	Ig-like V-type 2.					integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						GGGGCTCTGGGAACCAGCCCC	0.592000													6	29					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024773	76024773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76024773C>T	ENST00000393004.2	-	5	996	c.775G>A	c.(775-777)Gaa>Aaa	p.E259K	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.E259K|FILIP1_ENST00000370020.1_Missense_Mutation_p.E160K			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	259										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CCAAGTTGTTCAATGTGCATT	0.398000													58	105					0	0	1	0	0
ENPP1	5167	broad.mit.edu	37	6	132207802	132207802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:132207802G>A	ENST00000360971.2	+	24	2565	c.2545G>A	c.(2545-2547)Gaa>Aaa	p.E849K		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	849	Nuclease.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTTGCACTGTGAAAACCTAGA	0.378000													28	40					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037470	75037470	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75037470C>T	ENST00000326665.5	-	14	4142	c.3924G>A	c.(3922-3924)gcG>gcA	p.A1308A	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1308	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TGTCCTGCATCGCTTCTGTCT	0.542000													68	144					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85266876	85266876	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:85266876A>T	ENST00000266682.5	-	7	1640	c.1099T>A	c.(1099-1101)Tgc>Agc	p.C367S	SLC6A15_ENST00000309283.7_Missense_Mutation_p.C75S|SLC6A15_ENST00000551388.1_5'UTR|SLC6A15_ENST00000552192.1_Missense_Mutation_p.C260S	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	367					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						TGTGTAATGCATTTCTCATTT	0.318000													23	67					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72049908	72049908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:72049908C>T	ENST00000305425.4	-	9	2372	c.1950G>A	c.(1948-1950)acG>acA	p.T650T	DACH1_ENST00000359684.2_Silent_p.T702T|DACH1_ENST00000354591.4_Silent_p.T448T|DACH1_ENST00000313174.7_Silent_p.T502T	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	700	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CACGCCGTTTCGTCTCAAACT	0.388000													84	196					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176946947	176946947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:176946947C>T	ENST00000308618.4	-	2	794	c.658G>A	c.(658-660)Gag>Aag	p.E220K		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	220						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GCGGCCAGCTCGCACCGGCGG	0.632000													8	25					0	0	1	0	0
A4GALT	53947	broad.mit.edu	37	22	43089886	43089886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43089886G>A	ENST00000401850.1	-	2	561	c.72C>T	c.(70-72)ttC>ttT	p.F24F	A4GALT_ENST00000381278.3_Silent_p.F24F|A4GALT_ENST00000249005.2_Silent_p.F24F			Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	24					glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			NS(1)|central_nervous_system(2)|large_intestine(6)|skin(1)|urinary_tract(1)	11						AGCCGATGATGAACAGGGTGC	0.597000													10	18					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112020	57112020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57112020G>A	ENST00000454682.1	-	3	3575	c.3294C>T	c.(3292-3294)tcC>tcT	p.S1098S	NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000548563.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CCCCTTTGGGGGATGGGGTAG	0.662000			T	BCL6	NHL								20	53					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36224722	36224722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36224722C>T	ENST00000222270.7	+	30	7108	c.7108C>T	c.(7108-7110)Ccc>Tcc	p.P2370S	WBP7_ENST00000420124.1_Missense_Mutation_p.P2370S|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					TCCCCAGGTCCCCGATGGTCC	0.637000													19	40					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127379289	127379289	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127379289C>T	ENST00000342480.6	+	3	457	c.418C>T	c.(418-420)Cca>Tca	p.P140S		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	140					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						TCAAGAGCTGCCAAACCTCCC	0.498000													13	64					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50094243	50094243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50094243C>T	ENST00000376042.1	+	12	4262	c.3964C>T	c.(3964-3966)Ccc>Tcc	p.P1322S	CCNB3_ENST00000276014.7_Missense_Mutation_p.P1322S|CCNB3_ENST00000376038.1_Missense_Mutation_p.P218S|CCNB3_ENST00000348603.2_Missense_Mutation_p.P218S			Q8WWL7	CCNB3_HUMAN	cyclin B3	1322					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CTTCCAGGTTCCCTTCCTGGA	0.458000													62	37					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2718585	2718585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:2718585G>A	ENST00000382082.3	+	1	1084	c.846G>A	c.(844-846)gtG>gtA	p.V282V		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	282						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		TCAACACCGTGGAGGAGATGC	0.672000													3	16					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800647	21800647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21800647C>T	ENST00000443632.2	+	2	1835	c.1463C>T	c.(1462-1464)gCc>gTc	p.A488V	HIC2_ENST00000407464.2_Missense_Mutation_p.A488V|HIC2_ENST00000407598.2_Missense_Mutation_p.A488V			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	488					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GAGGAGGAGGCCGAGGACCTG	0.642000													11	43					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7618552	7618552	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7618552G>A	ENST00000256861.6	-	10	1920	c.1842C>T	c.(1840-1842)ttC>ttT	p.F614F	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Silent_p.F614F|ITIH5_ENST00000298441.6_Silent_p.F400F|ITIH5_ENST00000446830.2_Silent_p.F396F|ITIH5_ENST00000397145.2_Silent_p.F614F	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	614					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						AGGGAGTGAGGAAGCGGTAGC	0.667000													20	53					0	0	1	0	0
CNN3	1266	broad.mit.edu	37	1	95363566	95363566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:95363566G>A	ENST00000370206.4	-	7	1105	c.722C>T	c.(721-723)tCg>tTg	p.S241L	CNN3_ENST00000538964.1_Missense_Mutation_p.S241L|CNN3_ENST00000394202.4_Missense_Mutation_p.S195L|CNN3_ENST00000545882.1_Missense_Mutation_p.S200L|CNN3_ENST00000487539.1_5'UTR	NM_001839.3	NP_001830.1	Q15417	CNN3_HUMAN	calponin 3, acidic	241					actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|stomach(1)|urinary_tract(2)	18		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		GGAAATTGTCGAGTTGTCCAC	0.443000													45	126					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3424212	3424212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3424212C>T	ENST00000336727.3	+	11	3852	c.2948C>T	c.(2947-2949)tCc>tTc	p.S983F	RGS12_ENST00000338806.4_Missense_Mutation_p.S335F|RGS12_ENST00000508158.1_3'UTR|RGS12_ENST00000382788.3_Missense_Mutation_p.S983F|RGS12_ENST00000344733.5_Missense_Mutation_p.S983F|RGS12_ENST00000306648.7_Missense_Mutation_p.S381F|RGS12_ENST00000538395.1_Missense_Mutation_p.S325F	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	983	RBD 1.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCGGGCTTCTCCATCAAAGAC	0.632000													14	41					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4693861	4693861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4693861C>T	ENST00000302640.8	+	11	1260	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C	ITPR1_ENST00000456211.2_Missense_Mutation_p.R304C|ITPR1_ENST00000443694.2_Missense_Mutation_p.R304C|ITPR1_ENST00000357086.4_Missense_Mutation_p.R304C|ITPR1_ENST00000544951.1_Missense_Mutation_p.R304C|ITPR1_ENST00000423119.2_Missense_Mutation_p.R304C|ITPR1_ENST00000354582.6_Missense_Mutation_p.R304C	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	304	MIR 4.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CAGCCTTTTCCGTTTCAAGCA	0.522000													5	19					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22133973	22133973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22133973G>A	ENST00000408935.1	+	1	677	c.677G>A	c.(676-678)cGa>cAa	p.R226Q		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GTTTCTCTTCGAAAACACTCA	0.502000													30	60					0	0	1	0	0
OR7G1	125962	broad.mit.edu	37	19	9225552	9225552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9225552C>T	ENST00000293614.1	-	1	887	c.888G>A	c.(886-888)gaG>gaA	p.E296E	OR7G1_ENST00000541538.1_Silent_p.E296E			Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	20						CTTTCTTCATCTCCTTATTTC	0.413000													50	120					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111850537	111850537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:111850537G>A	ENST00000389811.4	+	18	1850	c.1626G>A	c.(1624-1626)agG>agA	p.R542R	ACOXL_ENST00000439055.1_Silent_p.R512R			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	542					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						CGAGGATCAGGAATCAGGTAA	0.458000													26	54					0	0	1	0	0
CD40LG	959	broad.mit.edu	37	X	135732492	135732492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135732492G>A	ENST00000370629.2	+	2	280	c.224G>A	c.(223-225)gGa>gAa	p.G75E	CD40LG_ENST00000370628.2_Missense_Mutation_p.G75E	NM_000074.2	NP_000065.1	P29965	CD40L_HUMAN	CD40 ligand	75					anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|skin(1)|stomach(1)	26	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	TGCAACACAGGAGAAAGATCC	0.343000									Immune Deficiency with Hyper-IgM				55	27					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72299376	72299376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72299376C>T	ENST00000263563.6	+	15	2034	c.1766C>T	c.(1765-1767)cCc>cTc	p.P589L		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		AGCGAGCCTCCCCCAGGCAAG	0.657000													19	50					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11631223	11631223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11631223C>T	ENST00000262442.3	+	28	5866	c.5798C>T	c.(5797-5799)tCa>tTa	p.S1933L	DNAH9_ENST00000454412.2_Missense_Mutation_p.S1933L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1933	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAGGTCTTGTCAGTGGTGGCA	0.493000													19	20					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374540	31374540	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31374540G>A	ENST00000268296.4	+	14	1676	c.1555G>A	c.(1555-1557)Ggt>Agt	p.G519S	ITGAX_ENST00000562522.1_Missense_Mutation_p.G519S	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	519					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CCACCCCTGGGGTCGCTTTGG	0.637000													56	100					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156230268	156230268	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156230268G>A	ENST00000361813.5	-	15	2401	c.2257C>T	c.(2257-2259)Cgg>Tgg	p.R753W	SMG5_ENST00000368267.4_Intron	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	753					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					AGCAGGGGCCGATCCGTGTCA	0.557000													16	142					0	0	1	0	0
MLLT1	4298	broad.mit.edu	37	19	6222145	6222145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6222145G>A	ENST00000252674.7	-	6	1260	c.1097C>T	c.(1096-1098)tCc>tTc	p.S366F		NM_005934.3	NP_005925.2	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	366					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						GGACTTGAAGGAGGCCTCGTC	0.642000			T	MLL	AL								7	22					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13538855	13538855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:13538855G>A	ENST00000341083.3	-	4	622	c.326C>T	c.(325-327)tCa>tTa	p.S109L	BEND7_ENST00000396898.2_Missense_Mutation_p.S174L|BEND7_ENST00000378605.3_Missense_Mutation_p.S122L|BEND7_ENST00000396900.2_Missense_Mutation_p.S161L	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	161							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						ACAGCAGTTTGATCCAGCTGA	0.378000													21	54					0	0	1	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152235965	152235965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152235965C>T	ENST00000243347.3	+	6	827	c.752C>T	c.(751-753)tCc>tTc	p.S251F		NM_007115.3	NP_009046.2	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	251					cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		GATCCTGTATCCAAATCCAGT	0.353000													36	123					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64746706	64746706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:64746706G>A	ENST00000543942.2	-	2	1009	c.383C>T	c.(382-384)cCa>cTa	p.P128L	C12orf56_ENST00000333722.5_Missense_Mutation_p.P128L|RPS11P6_ENST00000535684.1_RNA	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	128										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		ATGATGAAATGGAAATAGGAA	0.313000													15	46					0	0	1	0	0
HEXA	3073	broad.mit.edu	37	15	72638913	72638913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72638913G>A	ENST00000268097.5	-	11	1788	c.1285C>T	c.(1285-1287)Cct>Tct	p.P429S	HEXA_ENST00000429918.2_Missense_Mutation_p.P256S|RP11-106M3.2_ENST00000379915.4_RNA|RP11-106M3.3_ENST00000570175.1_RNA|HEXA_ENST00000566304.1_Missense_Mutation_p.P440S|HEXA_ENST00000457859.2_Intron|HEXA_ENST00000567159.1_Missense_Mutation_p.P429S	NM_000520.4	NP_000511.2	P06865	HEXA_HUMAN	hexosaminidase A (alpha polypeptide)	429					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(3)|kidney(3)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	24						TTCCAGTCAGGGCCATAGGAT	0.537000													111	206					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31907063	31907063	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31907063C>T	ENST00000456570.1	+	6	781	c.726C>T	c.(724-726)atC>atT	p.I242I	CFB_ENST00000477310.1_Silent_p.I213I|C2_ENST00000442278.2_Silent_p.I263I|C2_ENST00000452323.2_Silent_p.I181I|C2_ENST00000469372.1_Silent_p.I149I|C2_ENST00000299367.5_Silent_p.I395I|CFB_ENST00000556679.1_Silent_p.I242I			P00751	CFAB_HUMAN	complement factor B	408			I -> L (in AHUS4).		complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TCAGAGAGATCCTGAACATCA	0.463000													9	131					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124756397	124756397	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124756397G>A	ENST00000306534.3	-	16	3242	c.2757C>T	c.(2755-2757)ttC>ttT	p.F919F	RP11-664I21.5_ENST00000524453.1_RNA|ROBO4_ENST00000533054.1_Silent_p.F774F	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	919					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GCTCTAGACCGAAACCAAAGC	0.572000													29	54					0	0	1	0	0
FAM208A	23272	broad.mit.edu	37	3	56681165	56681165	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:56681165A>G	ENST00000431842.2	-	7	1336	c.412T>C	c.(412-414)Tct>Cct	p.S138P	FAM208A_ENST00000493960.2_Missense_Mutation_p.S534P|FAM208A_ENST00000355628.5_Missense_Mutation_p.S534P	NM_015224.3	NP_056039.2	Q9UK61	CC063_HUMAN	family with sequence similarity 208, member A	534										NS(1)|breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(11)|prostate(3)|skin(1)	32						TGAATCAAAGAAAATTGTAAA	0.338000													25	88					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51265502	51265502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51265502G>A	ENST00000266037.9	+	17	1653	c.1630G>A	c.(1630-1632)Gag>Aag	p.E544K		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	544	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGATATTCACGAGCTTTATGT	0.478000													18	31					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5947473	5947473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:5947473G>A	ENST00000378156.4	-	18	2623	c.2358C>T	c.(2356-2358)gtC>gtT	p.V786V	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	786					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTTGCCACGACCTCAAGCT	0.642000													16	47					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76491047	76491047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76491047C>T	ENST00000389840.5	-	39	6118	c.5994G>A	c.(5992-5994)tcG>tcA	p.S1998S	DNAH17_ENST00000585328.1_Silent_p.S2007S|RP11-559N14.5_ENST00000591373.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACACCTGCTTCGAGAGCAGCT	0.597000													6	19					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33289581	33289581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33289581G>A	ENST00000374542.5	-	2	326	c.122C>T	c.(121-123)tCc>tTc	p.S41F	DAXX_ENST00000477162.1_5'UTR|DAXX_ENST00000266000.6_Missense_Mutation_p.S41F|DAXX_ENST00000414083.2_Intron	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	41	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						AGGCTCAGAGGAGCTAGGGGC	0.587000			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								116	224					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64055334	64055334	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64055334C>T	ENST00000539851.1	+	4	1016	c.549C>T	c.(547-549)ttC>ttT	p.F183F	GPR137_ENST00000313074.3_Silent_p.F183F|GPR137_ENST00000411458.1_Silent_p.F241F|GPR137_ENST00000438980.2_Silent_p.F183F|GPR137_ENST00000377702.4_Silent_p.F183F	NM_001177358.1	NP_001170829.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	183						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						ACTCCCTGTTCGTCATCTGCG	0.662000													21	49					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018929	62018929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62018929G>A	ENST00000578147.1	-	24	4789	c.4713C>T	c.(4711-4713)ccC>ccT	p.P1571P	SCN4A_ENST00000435607.1_Silent_p.P1571P			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1571					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TGCCGATGGAGGGGTTGCCGC	0.577000													5	51					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15600127	15600127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15600127C>T	ENST00000378076.3	-	26	3065	c.2712G>A	c.(2710-2712)agG>agA	p.R904R		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	904					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CATCCCTCTTCCTGACAAGAT	0.498000													30	88					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39454590	39454590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39454590C>T	ENST00000280481.7	+	24	9392	c.9176C>T	c.(9175-9177)cCc>cTc	p.P3059L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	3059					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AGGAGCACACCCTCACTGGCA	0.537000													15	92					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53668167	53668167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53668167G>A	ENST00000600412.1	-	2	1496	c.1381C>T	c.(1381-1383)Cat>Tat	p.H461Y	ZNF665_ENST00000396424.3_Missense_Mutation_p.H526Y			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		AGGCTTGAATGAACACTAAAG	0.388000													44	127					0	0	1	0	0
JKAMP	51528	broad.mit.edu	37	14	59954436	59954436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:59954436G>A	ENST00000554271.1	+	3	709	c.183G>A	c.(181-183)caG>caA	p.Q61Q	JKAMP_ENST00000557560.1_3'UTR|JKAMP_ENST00000556985.1_Silent_p.Q47Q|JKAMP_ENST00000356057.5_Silent_p.Q55Q|RP11-701B16.2_ENST00000554253.1_RNA|JKAMP_ENST00000261247.9_Silent_p.Q47Q|JKAMP_ENST00000425728.2_Silent_p.Q41Q			Q9P055	JKAMP_HUMAN	JNK1/MAPK8-associated membrane protein	62					ER-associated protein catabolic process|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ubiquitin protein ligase binding			breast(1)|endometrium(1)|kidney(1)|lung(3)	6						AATATTGTCAGCCTTGCACAG	0.358000													88	193					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887508	9887508	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:9887508C>T	ENST00000306084.6	+	2	1231	c.1032C>T	c.(1030-1032)atC>atT	p.I344I	TXNDC2_ENST00000357775.4_Silent_p.I277I|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	344	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AGGGTGACATCCCCAAGTCCC	0.577000													68	133					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27949645	27949645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27949645C>T	ENST00000374005.3	-	4	525	c.237G>A	c.(235-237)gtG>gtA	p.V79V	FGR_ENST00000399173.1_Silent_p.V79V|FGR_ENST00000374004.1_Silent_p.V79V|FGR_ENST00000545953.1_Silent_p.V79V	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	79	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TGAACAGGGTCACCCCAATCC	0.562000													10	24					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25264840	25264840	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25264840T>A	ENST00000218548.6	+	7	1113	c.780T>A	c.(778-780)taT>taA	p.Y260*	ATP12A_ENST00000381946.3_Nonsense_Mutation_p.Y260*	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	260					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TCTGCTTCTATTCCACAACGT	0.547000													101	248					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72340461	72340461	+	Missense_Mutation	SNP	G	G	A	rs141653211		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72340461G>A	ENST00000389916.4	+	6	694	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	186	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CGGCATCACCGAAGTCTCCAC	0.632000													10	25					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519925	69519925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69519925G>A	ENST00000338206.5	-	5	1152	c.1143C>T	c.(1141-1143)atC>atT	p.I381I		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	381					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										TCGCCTCATAGATGCCATTGG	0.413000													62	224					0	0	1	0	0
TMEM150B	284417	broad.mit.edu	37	19	55824350	55824350	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55824350G>A	ENST00000326652.4	-	8	761	c.579C>T	c.(577-579)ttC>ttT	p.F193F	TMEM150B_ENST00000438693.1_Silent_p.F193F			A6NC51	T150B_HUMAN	transmembrane protein 150B	193						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						CGAAGAGCGCGAACAGCAGCA	0.682000													11	34					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41583305	41583305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41583305C>T	ENST00000396942.1	-	6	669	c.586G>A	c.(586-588)Gac>Aac	p.D196N	ANK1_ENST00000352337.4_Missense_Mutation_p.D196N|ANK1_ENST00000396945.1_Missense_Mutation_p.D196N|ANK1_ENST00000289734.7_Missense_Mutation_p.D196N|ANK1_ENST00000379758.2_Missense_Mutation_p.D196N|ANK1_ENST00000265709.8_Missense_Mutation_p.D229N|ANK1_ENST00000347528.4_Missense_Mutation_p.D196N			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	196	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGGTTGGGGTCGTTCTGCAGC	0.716000													7	13					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25042867	25042867	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:25042867C>T	ENST00000216336.2	-	5	780	c.744G>A	c.(742-744)ctG>ctA	p.L248L		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	248					immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		CCATCTGATCCAGCAGTTTGA	0.507000													67	289					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927205	130927205	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130927205C>T	ENST00000261655.4	-	8	804	c.640_splice	c.e8-1	p.G214_splice	RIMBP2_ENST00000536002.1_Splice_Site_p.G122_splice|RIMBP2_ENST00000535703.1_Splice_Site_p.G122_splice	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	214	SH3 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GAGGAGCTCTCCTGTTGGGTA	0.617000													5	35					0	0	1	0	0
SNRPN	6638	broad.mit.edu	37	15	25220525	25220525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25220525G>A	ENST00000444203.2	+	3	1075	c.36G>A	c.(34-36)aaG>aaA	p.K12K	SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000400098.1_Silent_p.K8K|SNRPN_ENST00000346403.6_Silent_p.K8K|SNRPN_ENST00000390687.4_Silent_p.K8K|SNRPN_ENST00000554227.2_Silent_p.K12K|SNRPN_ENST00000400100.1_Silent_p.K8K|SNRPN_ENST00000577565.1_Silent_p.K8K|SNRPN_ENST00000400097.1_Silent_p.K8K			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	8					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		AGAGTAGCAAGATGCTGCAGC	0.433000									Prader-Willi syndrome				29	96					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29598859	29598859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29598859G>A	ENST00000431530.3	+	1	112	c.54G>A	c.(52-54)aaG>aaA	p.K18K		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	8						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TGGCTCCTAAGAAATCATGTT	0.448000													22	90					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38538831	38538831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38538831G>A	ENST00000399017.2	+	33	7062	c.4315G>A	c.(4315-4317)Gga>Aga	p.G1439R	TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Missense_Mutation_p.G1439R|TTC3_ENST00000355666.1_Missense_Mutation_p.G1439R	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1439					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TGAGCACTGTGGAAATTCTAA	0.423000													22	68					0	0	1	0	0
CAMK2A	815	broad.mit.edu	37	5	149627351	149627351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149627351G>A	ENST00000348628.6	-	12	1592	c.927C>T	c.(925-927)gcC>gcT	p.A309A	CAMK2A_ENST00000398376.3_Silent_p.A309A	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	309					interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTTCCTGGTGGCCAGCATCG	0.617000													4	12					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140627270	140627270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140627270C>T	ENST00000231173.3	+	1	2124	c.2124C>T	c.(2122-2124)ttC>ttT	p.F708F		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		708					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTCCTGTTCGTGGCAGTGC	0.677000													54	265					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56277733	56277733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56277733G>A	ENST00000225371.5	+	10	1795	c.1685G>A	c.(1684-1686)cGa>cAa	p.R562Q		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	562					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						AACATGCAACGAAGCCGGGAC	0.617000											OREG0024608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	70					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16992006	16992006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:16992006G>A	ENST00000377833.4	-	34	5139	c.5074C>T	c.(5074-5076)Ctc>Ttc	p.L1692F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1692	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTACCTCGGAGGGGCGCGTCT	0.463000													4	18					0	0	1	0	0
TMEM8B	51754	broad.mit.edu	37	9	35846306	35846306	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35846306G>A	ENST00000377988.2	+	8	1713	c.425G>A	c.(424-426)aGg>aAg	p.R142K	TMEM8B_ENST00000377991.4_Missense_Mutation_p.R142K|TMEM8B_ENST00000439587.2_Missense_Mutation_p.R142K|TMEM8B_ENST00000377996.1_Missense_Mutation_p.R142K|TMEM8B_ENST00000473947.1_3'UTR	NM_001042590.2	NP_001036055.1	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B	142					cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	7						AGGGTTGCCAGGCTGCGAATC	0.687000													10	69					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219875364	219875364	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219875364G>A	ENST00000341552.5	-	26	4295	c.4212C>T	c.(4210-4212)ggC>ggT	p.G1404G	CCDC108_ENST00000441968.1_Silent_p.G1404G|AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000453220.1_Silent_p.G1404G	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1404						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGGTTGTAGCCCACTCCCT	0.592000													7	14					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120876350	120876350	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120876350G>A	ENST00000273666.6	+	9	1024		c.e9-1		STXBP5L_ENST00000471454.1_Splice_Site|STXBP5L_ENST00000492541.1_Splice_Site|STXBP5L_ENST00000497029.1_Splice_Site|STXBP5L_ENST00000472879.1_Splice_Site	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like						exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		TATTTTATTAGGCTATTCATT	0.328000													15	49					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14492705	14492705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14492705C>T	ENST00000344204.4	+	49	7686	c.7662C>T	c.(7660-7662)tcC>tcT	p.S2554S	TRIO_ENST00000537187.1_Silent_p.S2378S|TRIO_ENST00000344135.5_Silent_p.S53S	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2554	SH3 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GCAACATCTCCACCATGTTGG	0.502000													17	39					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2824232	2824232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2824232C>T	ENST00000520002.1	-	59	9518	c.8963G>A	c.(8962-8964)gGa>gAa	p.G2988E	CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000537824.1_Missense_Mutation_p.G2987E|CSMD1_ENST00000602723.1_Intron|CSMD1_ENST00000400186.3_Intron|CSMD1_ENST00000602557.1_Missense_Mutation_p.G2988E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2988	Sushi 23.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GACAATCATTCCGTTGGTGGG	0.527000													4	17					0	0	1	0	0
NSDHL	50814	broad.mit.edu	37	X	152034497	152034497	+	Silent	SNP	C	C	T	rs147293409	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:152034497C>T	ENST00000370274.3	+	6	872	c.678C>T	c.(676-678)ttC>ttT	p.F226F	NSDHL_ENST00000440023.1_Silent_p.F226F	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	226					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity	p.F226F(1)		NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	AGATGAAGTTCGTGATTGGGT	0.572000													47	38					0	0	1	0	0
CEACAM21	90273	broad.mit.edu	37	19	42082636	42082636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42082636C>T	ENST00000187608.9	+	1	50	c.10C>T	c.(10-12)Ccc>Tcc	p.P4S	CEACAM21_ENST00000401445.2_Missense_Mutation_p.P4S|CEACAM21_ENST00000482870.2_Intron|CEACAM21_ENST00000407170.2_Intron	NM_001098506.1|NM_033543.3	NP_001091976.1|NP_291021.2	Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	4						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						CATGGGGCCCCCCTCAGCTTG	0.622000													10	43					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82456472	82456472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:82456472G>A	ENST00000370728.1	+	25	4668	c.4023G>A	c.(4021-4023)aaG>aaA	p.K1341K	LPHN2_ENST00000359929.3_Silent_p.K1285K|LPHN2_ENST00000394879.1_Silent_p.K1343K|LPHN2_ENST00000370730.1_Silent_p.K1298K|LPHN2_ENST00000271029.4_Silent_p.K1313K|LPHN2_ENST00000370715.1_3'UTR|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000335786.5_Silent_p.K1298K|LPHN2_ENST00000370725.1_Silent_p.K1356K|LPHN2_ENST00000370723.1_Silent_p.K1343K|LPHN2_ENST00000370721.1_Silent_p.K1266K|LPHN2_ENST00000370713.1_3'UTR|LPHN2_ENST00000319517.6_Silent_p.K1285K|LPHN2_ENST00000370717.2_Silent_p.K1356K|LPHN2_ENST00000370727.1_Silent_p.K1313K			O95490	LPHN2_HUMAN	latrophilin 2	1341					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AACCCCAGAAGAAAGTGAAGT	0.517000													46	98					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150440092	150440092	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150440092C>T	ENST00000358647.3	+	3	1232	c.865C>T	c.(865-867)Cta>Tta	p.L289L	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTTTGTTTTTCTATTGTTGTG	0.398000													18	59					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933292	44933292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44933292C>T	ENST00000291187.4	-	6	1968	c.1646G>A	c.(1645-1647)cGg>cAg	p.R549Q	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Missense_Mutation_p.R555Q	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	555					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GTCGGAGCTCCGGCCAAAGCT	0.532000													14	105					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46287520	46287520	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46287520G>A	ENST00000378966.3	+	2	668	c.252G>A	c.(250-252)cgG>cgA	p.R84R	SPERT_ENST00000310521.1_Silent_p.R120R			Q8NA61	SPERT_HUMAN	spermatid associated	120						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		ACCCGCCGCGGGTGCAGCTCA	0.627000													33	82					0	0	1	0	0
PRIMA1	145270	broad.mit.edu	37	14	94203587	94203587	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94203587C>T	ENST00000393140.1	-	4	461	c.359_splice	c.e4+1	p.R120_splice	PRIMA1_ENST00000316227.3_Splice_Site_p.R120_splice|PRIMA1_ENST00000393143.1_Splice_Site_p.R120_splice	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	120					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		GAGCACTCACCTTTTTATGGC	0.493000													16	42					0	0	1	0	0
XKR5	389610	broad.mit.edu	37	8	6679508	6679508	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:6679508G>A	ENST00000518724.1	-	0	840							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		TGCTGTCGATGATGTCACTCT	0.587000													8	7					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63676695	63676695	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63676695G>A	ENST00000402010.2	+	19	2932	c.2353G>A	c.(2353-2355)Gag>Aag	p.E785K	MARK2_ENST00000361128.5_Missense_Mutation_p.E716K|MARK2_ENST00000513765.2_Missense_Mutation_p.E752K|MARK2_ENST00000315032.8_Missense_Mutation_p.E776K|MARK2_ENST00000350490.7_Missense_Mutation_p.E706K|MARK2_ENST00000425897.2_Missense_Mutation_p.E696K|MARK2_ENST00000377809.4_Missense_Mutation_p.E770K|MARK2_ENST00000502399.3_Missense_Mutation_p.E775K|MARK2_ENST00000377810.3_Missense_Mutation_p.E688K|MARK2_ENST00000408948.3_Missense_Mutation_p.E688K|MARK2_ENST00000508192.1_Missense_Mutation_p.E721K|MARK2_ENST00000509502.2_Missense_Mutation_p.E742K|MARK2_ENST00000413835.2_Missense_Mutation_p.E731K	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	785	KA1.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						AATAGCCAACGAGCTGAAGCT	0.647000													21	56					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577226	14577226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14577226C>T	ENST00000544627.1	+	2	721	c.401C>T	c.(400-402)cCt>cTt	p.P134L	ATF7IP_ENST00000536444.1_Missense_Mutation_p.P126L|ATF7IP_ENST00000543189.1_Missense_Mutation_p.P126L|ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000540793.1_Missense_Mutation_p.P126L|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P126L			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	126					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TCTAAACTGCCTGCTGAACCA	0.473000													12	65					0	0	1	0	0
PAK4	10298	broad.mit.edu	37	19	39669068	39669068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39669068C>T	ENST00000599386.1	+	9	1347	c.1166C>T	c.(1165-1167)tCg>tTg	p.S389L	PAK4_ENST00000599470.1_Missense_Mutation_p.S389L|PAK4_ENST00000593690.1_Missense_Mutation_p.S542L|PAK4_ENST00000360442.3_Missense_Mutation_p.S542L|PAK4_ENST00000358301.3_Missense_Mutation_p.S542L|PAK4_ENST00000321944.4_Missense_Mutation_p.S452L|PAK4_ENST00000435673.2_Missense_Mutation_p.S542L	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	542	Protein kinase.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			CGACAGGTGTCGCCATCCCTG	0.672000													4	2					0	0	1	0	0
BBS7	55212	broad.mit.edu	37	4	122776679	122776679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122776679G>A	ENST00000264499.4	-	6	749	c.566C>T	c.(565-567)cCc>cTc	p.P189L	BBS7_ENST00000506636.1_Missense_Mutation_p.P189L	NM_176824.2	NP_789794.1	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7	189					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						GACAGTAGGGGGTCCAGGAAC	0.348000									Bardet-Biedl syndrome				58	116					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504556	70504556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70504556G>A	ENST00000310961.5	+	22	3368	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K	LRRC7_ENST00000415775.2_Missense_Mutation_p.E263K|LRRC7_ENST00000035383.5_Missense_Mutation_p.E979K			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	979						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGGAAGCCACGAACGACCGGA	0.453000													21	70					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130341178	130341178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130341178G>A	ENST00000299164.2	+	7	1978	c.1978G>A	c.(1978-1980)Gat>Aat	p.D660N		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	660	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GGCTGGCTGTGATGGGAACCT	0.567000													9	54					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78347272	78347272	+	Missense_Mutation	SNP	G	G	A	rs35879437		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78347272G>A	ENST00000255189.3	-	5	611	c.583C>T	c.(583-585)Cct>Tct	p.P195S	DMGDH_ENST00000540686.1_Intron|DMGDH_ENST00000380311.4_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	195					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		AGAGAATAAGGATCAATGTGA	0.388000													41	98					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2910072	2910072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2910072G>A	ENST00000520002.1	-	51	8130	c.7575C>T	c.(7573-7575)ggC>ggT	p.G2525G	CSMD1_ENST00000542608.1_Silent_p.G2524G|CSMD1_ENST00000537824.1_Silent_p.G2524G|CSMD1_ENST00000602723.1_Silent_p.G2525G|CSMD1_ENST00000400186.3_Silent_p.G2525G|CSMD1_ENST00000602557.1_Silent_p.G2525G			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2525	Sushi 15.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAAGCTTGAAGCCCTCATGAC	0.507000													3	14					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2592604	2592604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2592604G>A	ENST00000155840.5	+	4	762	c.654G>A	c.(652-654)aaG>aaA	p.K218K	KCNQ1_ENST00000335475.5_Silent_p.K91K	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	218					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	TGGGCTCCAAGGGGCAGGTGT	0.682000													24	60					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954940	30954940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30954940G>A	ENST00000376296.3	+	2	1229	c.988G>A	c.(988-990)Gcc>Acc	p.A330T	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	330	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						GGCCAGCACAGCCACCAACTC	0.622000													26	335					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861734	52861734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52861734G>A	ENST00000343457.3	-	4	1460	c.1454C>T	c.(1453-1455)tCg>tTg	p.S485L		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	485						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						TGGGCTCTGCGAACTGCCAGG	0.557000													33	82					0	0	1	0	0
PPP3R2	5535	broad.mit.edu	37	9	104356906	104356906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104356906C>T	ENST00000374806.1	-	1	377	c.307G>A	c.(307-309)Gac>Aac	p.D103N	GRIN3A_ENST00000361820.3_Intron	NM_147180.2	NP_671709.1	Q96LZ3	CANB2_HUMAN	protein phosphatase 3, regulatory subunit B, beta	100	EF-hand 3.						calcium ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	TTATCCATGTCGTAAATGCTG	0.532000													29	114					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30938508	30938508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30938508C>T	ENST00000597505.1	-	24	3360	c.3361G>A	c.(3361-3363)Gaa>Aaa	p.E1121K	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Missense_Mutation_p.E200K			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TGTGAAGTTTCCTGCCAGGCA	0.418000													21	52					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935259	151935259	+	Missense_Mutation	SNP	G	G	A	rs35981027		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151935259G>A	ENST00000393902.3	-	3	1475	c.908C>T	c.(907-909)cCc>cTc	p.P303L	MAGEA3_ENST00000370278.3_Missense_Mutation_p.P303L			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	303	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CTCATGCAGGGGTGGGTAGGA	0.577000													21	128					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49219119	49219119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49219119G>A	ENST00000327979.2	-	13	1548	c.1137C>T	c.(1135-1137)atC>atT	p.I379I	FAM65C_ENST00000045083.2_Silent_p.I379I|FAM65C_ENST00000535356.1_Silent_p.I383I			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	379										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GGTAGCTGAGGATGGAGGTGG	0.647000													6	78					0	0	1	0	0
AHSP	51327	broad.mit.edu	37	16	31539877	31539877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31539877G>A	ENST00000302312.4	+	3	277	c.174G>A	c.(172-174)ggG>ggA	p.G58G	AHSP_ENST00000569954.1_3'UTR	NM_016633.2	NP_057717.1	Q9NZD4	AHSP_HUMAN	alpha hemoglobin stabilizing protein	58					hemoglobin metabolic process|hemopoiesis|protein folding|protein stabilization	hemoglobin complex	hemoglobin binding|unfolded protein binding			lung(2)	2						AGGTGACAGGGGAGCCCCAAG	0.532000													12	54					0	0	1	0	0
LMOD1	25802	broad.mit.edu	37	1	201868737	201868737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201868737G>A	ENST00000367288.4	-	2	1650	c.1404C>T	c.(1402-1404)agC>agT	p.S468S	RP11-307B6.3_ENST00000458139.1_RNA|RP11-307B6.3_ENST00000414927.1_RNA	NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	468					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CCATGTTGCGGCTGAGCAGAT	0.572000													6	16					0	0	1	0	0
MTHFD2L	441024	broad.mit.edu	37	4	75167517	75167517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:75167517C>T	ENST00000395759.2	+	8	1062	c.1035C>T	c.(1033-1035)atC>atT	p.I345I	MTHFD2L_ENST00000325278.6_Silent_p.I287I	NM_001144978.1	NP_001138450.1	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	287					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			central_nervous_system(1)|endometrium(1)|lung(4)|ovary(2)	8			all cancers(17;0.0101)|Lung(101;0.196)			CTAAAAAAATCATTTACTAGA	0.363000													11	41					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148112693	148112693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148112693G>A	ENST00000361727.3	+	24	4497	c.3981G>A	c.(3979-3981)aaG>aaA	p.K1327K	CNTNAP2_ENST00000463592.2_3'UTR|CNTNAP2_ENST00000538075.1_Silent_p.K386K	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1327					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AAAGCAAAAAGGAATGGCTCA	0.522000										HNSCC(39;0.1)			31	48					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198948911	198948911	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:198948911C>T	ENST00000428675.1	+	2	1068	c.670C>T	c.(670-672)Cga>Tga	p.R224*	PLCL1_ENST00000437704.2_Nonsense_Mutation_p.R126*	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	224					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CCTGGTTTCTCGAAGTAAGCA	0.478000													33	85					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128492726	128492726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128492726G>A	ENST00000325888.8	+	36	6185	c.5924G>A	c.(5923-5925)aGc>aAc	p.S1975N	FLNC_ENST00000346177.6_Missense_Mutation_p.S1942N|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1975					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						AGTGATCTGAGCCAGCTGACC	0.647000													37	60					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599939	29599939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29599939C>T	ENST00000431530.3	+	1	1192	c.1134C>T	c.(1132-1134)ctC>ctT	p.L378L		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	368						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						ACAGTGACCTCCACCACCTTG	0.572000													9	31					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75500155	75500155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75500155G>A	ENST00000355774.2	-	7	3897	c.3682C>T	c.(3682-3684)Cat>Tat	p.H1228Y	MLH3_ENST00000556257.1_Intron|MLH3_ENST00000544985.1_3'UTR|MLH3_ENST00000380968.2_Missense_Mutation_p.H174Y|MLH3_ENST00000556740.1_Missense_Mutation_p.H1228Y|MLH3_ENST00000238662.7_Intron	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	1228					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding	p.H1228N(1)		breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		ATACGCTCATGGGCAGCGTGC	0.478000								Mismatch excision repair (MMR)					15	42					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14752260	14752260	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14752260G>A	ENST00000253673.5	-	10	1319	c.1219C>T	c.(1219-1221)Ctc>Ttc	p.L407F	EMR3_ENST00000443157.2_Missense_Mutation_p.L281F|EMR3_ENST00000599900.1_Missense_Mutation_p.L192F|EMR3_ENST00000344373.4_Missense_Mutation_p.L355F	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	407					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						ATCCCCACGAGGAAGAGGAGG	0.567000													20	74					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23915544	23915544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:23915544G>A	ENST00000382298.3	-	10	3059	c.2471C>T	c.(2470-2472)tCg>tTg	p.S824L	SACS_ENST00000402364.1_Missense_Mutation_p.S74L|SACS_ENST00000382292.3_Missense_Mutation_p.S824L	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	824				QTCVELIRLRIPSLVILDDES -> FLFDEDSNGKLKMVAV LITSC (in Ref. 3; CAE45964).	cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATGACTAACGATGGAATCCT	0.383000													36	82					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76900393	76900393	+	Missense_Mutation	SNP	G	G	A	rs111033214		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76900393G>A	ENST00000409709.3	+	28	3780	c.3508G>A	c.(3508-3510)Gag>Aag	p.E1170K	MYO7A_ENST00000409619.2_Missense_Mutation_p.E1159K|MYO7A_ENST00000458637.2_Missense_Mutation_p.E1170K	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1170	MyTH4 1.		E -> K (in USH1B).		actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCCCAGGGACGAGATCTACTG	0.642000													7	49					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759299	6759299	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6759299C>T	ENST00000378827.4	+	3	1973	c.754C>T	c.(754-756)Caa>Taa	p.Q252*		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	252					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GTCTTTGCACCAAGATGAACA	0.483000													10	31					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156834179	156834179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156834179G>A	ENST00000368196.3	+	2	366	c.246G>A	c.(244-246)ctG>ctA	p.L82L	NTRK1_ENST00000358660.3_Silent_p.L82L|NTRK1_ENST00000392302.2_Silent_p.L52L|NTRK1_ENST00000524377.1_Silent_p.L82L	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	82					activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGCAGCATCTGGAGCTCCGTG	0.617000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			14	36					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96916161	96916161	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96916161C>T	ENST00000267584.4	+	9	937	c.893C>T	c.(892-894)cCt>cTt	p.P298L		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	298					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		AATACTGGCCCTGGGAAAATC	0.353000													17	36					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13700828	13700828	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13700828C>T	ENST00000265104.4	-	78	13748	c.13644G>A	c.(13642-13644)agG>agA	p.R4548R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4548					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTTTCATGTTCCTCTTGTCCC	0.423000									Kartagener syndrome				84	186					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94731275	94731275	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94731275G>A	ENST00000304338.3	+	20	2342	c.2188G>A	c.(2188-2190)Gaa>Aaa	p.E730K		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	730						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TAAAATGTTTGAAAAGAAACG	0.313000													40	127					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83411176	83411176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:83411176G>A	ENST00000262752.2	-	3	172	c.165C>T	c.(163-165)atC>atT	p.I55I	RPS6KA6_ENST00000543399.1_Silent_p.I55I	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	55					axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						GAGTAATAGGGATTTCTTTAA	0.363000													8	11					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331568	70331568	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70331568C>T	ENST00000338508.4	-	32	4832	c.4833G>A	c.(4831-4833)gaG>gaA	p.E1611E	SHANK2_ENST00000449833.2_Silent_p.E1015E|SHANK2_ENST00000423696.2_Silent_p.E1231E|SHANK2_ENST00000409161.1_Silent_p.E1014E			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1231					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGCTTTTGATCTCTGTGACGT	0.592000													22	121					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55336670	55336670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:55336670C>T	ENST00000536015.1	-	18	2096	c.1977G>A	c.(1975-1977)aaG>aaA	p.K659K	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Silent_p.K659K|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	659			Missing (in PFIC1).		ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				CTTCAATTTCCTTGTAGCAAA	0.343000													12	49					0	0	1	0	0
PPP6C	5537	broad.mit.edu	37	9	127915924	127915924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127915924G>A	ENST00000451402.1	-	7	888	c.668C>T	c.(667-669)cCt>cTt	p.P223L	PPP6C_ENST00000373547.4_Missense_Mutation_p.P186L|PPP6C_ENST00000415905.1_Missense_Mutation_p.P164L|PPP6C_ENST00000373546.3_Missense_Mutation_p.P39L	NM_001123355.1	NP_001116827.1	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit	186					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						TCCTTTATGAGGAATTTCCTG	0.433000													5	58					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419274	130419274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130419274G>A	ENST00000370904.1	-	11	1429	c.519C>T	c.(517-519)gcC>gcT	p.A173A	IGSF1_ENST00000370903.3_Silent_p.A182A|IGSF1_ENST00000370901.4_Silent_p.A182A|IGSF1_ENST00000370910.1_Silent_p.A173A|IGSF1_ENST00000370900.1_Silent_p.A182A|IGSF1_ENST00000361420.3_Silent_p.A182A			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	182	Ig-like C2-type 2.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TGGAGAATATGGCCATTGTCC	0.517000													50	52					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150714977	150714977	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150714977C>T	ENST00000335244.4	-	6	786	c.657G>A	c.(655-657)cgG>cgA	p.R219R	SLC36A2_ENST00000521967.1_Silent_p.R219R	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	219					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCTGAGGTTCCGGATGAGGA	0.537000													14	80					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590255	140590255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140590255G>A	ENST00000239450.2	+	1	1965	c.1776G>A	c.(1774-1776)gtG>gtA	p.V592V	PCDHB12_ENST00000541609.1_Silent_p.V255V	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		592	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGGCGGTGGACGGTGACT	0.701000													15	301					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13397666	13397666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13397666C>T	ENST00000360228.5	-	20	3203	c.3204G>A	c.(3202-3204)atG>atA	p.M1068I	CACNA1A_ENST00000573710.2_Missense_Mutation_p.M1069I	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1069					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGTTGTTCTTCATGTTGTCAA	0.672000													11	27					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140277662	140277662	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140277662C>T	ENST00000458420.3	+	12	2194	c.2004C>T	c.(2002-2004)ttC>ttT	p.F668F		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	668					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						TGAGCACCTTCGCCAAAACCG	0.532000										HNSCC(16;0.037)			20	56					0	0	1	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206977	142206977	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142206977G>A	ENST00000426318.2	-	0	34																											TCCAGGGCAGGATCTTGTGTC	0.552000													15	25					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6093215	6093215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6093215C>T	ENST00000217289.4	-	4	1229	c.441G>A	c.(439-441)aaG>aaA	p.K147K	FERMT1_ENST00000536936.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	147	FERM.|Poly-Lys.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TCTTCTTCTTCTTAAAATAGT	0.299000													28	102					0	0	1	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140866223	140866223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140866223C>T	ENST00000306593.1	+	1	1483	c.1483C>T	c.(1483-1485)Ctg>Ttg	p.L495L	PCDHGA9_ENST00000573521.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACTCACTCCTGGAGCCCAG	0.522000													15	176					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6941024	6941024	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6941024G>A	ENST00000251761.8	+	0	1191				LEPREL2_ENST00000538102.1_RNA|LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						CCCTGGGGGAGAAGAGGCAGC	0.612000													7	10					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12660110	12660110	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12660110G>A	ENST00000251849.4	-	2	550	c.111C>T	c.(109-111)ggC>ggT	p.G37G	RAF1_ENST00000542177.1_5'UTR|RAF1_ENST00000442415.2_Silent_p.G37G	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	37					activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	GGCGCTGATAGCCAAACTGCT	0.468000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				34	78					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20054963	20054963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20054963C>T	ENST00000245957.5	+	4	388	c.312C>T	c.(310-312)ttC>ttT	p.F104F	C20orf26_ENST00000451767.2_Silent_p.F104F|C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377306.1_Silent_p.F104F|C20orf26_ENST00000377309.2_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	104										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ATACGTTGTTCATGCACCTCT	0.507000													40	109					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59282476	59282476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59282476C>T	ENST00000329328.3	+	1	91	c.91C>T	c.(91-93)Ctg>Ttg	p.L31L		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						ATTTACCTTCCTGTTTTTGGT	0.433000													11	204					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683361	100683361	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100683361C>T	ENST00000306151.4	+	3	8728	c.8664C>T	c.(8662-8664)acC>acT	p.T2888T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2888	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.T2888T(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGGCTAGCACCCTTTCAACAA	0.483000													171	478					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139889761	139889761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139889761C>T	ENST00000297183.6	+	22	4223	c.4099C>T	c.(4099-4101)Cgc>Tgc	p.R1367C	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.R1367C|ANKHD1_ENST00000360839.2_Missense_Mutation_p.R1367C	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCAGCATTTCGCAAGGTAAT	0.388000													28	55					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55059688	55059688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55059688C>T	ENST00000371316.3	+	5	529	c.447C>T	c.(445-447)ttC>ttT	p.F149F	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000343744.2_Silent_p.F149F	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	149	Acyl coenzyme A hydrolase 1.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						TGGCCACCTTCGTGGCCCGCC	0.632000													6	57					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35183432	35183432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:35183432C>T	ENST00000381318.3	+	21	2761	c.2473C>T	c.(2473-2475)Ccc>Tcc	p.P825S	ITSN1_ENST00000379960.5_Missense_Mutation_p.P820S|ITSN1_ENST00000381285.4_Missense_Mutation_p.P825S|ITSN1_ENST00000381291.4_Missense_Mutation_p.P825S|ITSN1_ENST00000399367.3_Missense_Mutation_p.P820S|ITSN1_ENST00000399355.2_Missense_Mutation_p.P825S|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000399326.3_Missense_Mutation_p.P820S|ITSN1_ENST00000399338.4_Missense_Mutation_p.P820S|ITSN1_ENST00000399349.1_Missense_Mutation_p.P820S|ITSN1_ENST00000399352.1_Missense_Mutation_p.P820S|ITSN1_ENST00000437442.2_Missense_Mutation_p.P820S|ITSN1_ENST00000399353.1_Missense_Mutation_p.P783S	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	825					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						TGCCCCTGCCCCCAAACTGGC	0.552000													23	105					0	0	1	0	0
DNHD1	144132	broad.mit.edu	37	11	6532654	6532654	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6532654C>T	ENST00000254579.6	+	7	1951	c.1387C>T	c.(1387-1389)Cga>Tga	p.R463*	DNHD1_ENST00000354685.3_Nonsense_Mutation_p.R463*|DNHD1_ENST00000527990.2_Nonsense_Mutation_p.R463*	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	463					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ATCCATTCTTCGACTGGTAAG	0.517000													46	94					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141721479	141721479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141721479G>A	ENST00000475668.2	+	6	706	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K	MGAM_ENST00000549489.2_Missense_Mutation_p.E218K			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	218	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTACCAAGTTGAAATCTCCAG	0.438000													33	97					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24654769	24654769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24654769G>A	ENST00000354464.6	-	13	1350	c.1174C>T	c.(1174-1176)Ctg>Ttg	p.L392L	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	392					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		AGTGGGGGCAGCAGTCTGGAT	0.552000													25	57					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55444962	55444962	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55444962G>A	ENST00000446217.1	-	10	3103	c.2701C>T	c.(2701-2703)Cct>Tct	p.P901S	NLRP7_ENST00000592784.1_Missense_Mutation_p.P873S|NLRP7_ENST00000340844.2_Missense_Mutation_p.P873S|NLRP7_ENST00000588756.1_Missense_Mutation_p.P873S|NLRP7_ENST00000448121.2_Missense_Mutation_p.P845S|NLRP7_ENST00000328092.5_Missense_Mutation_p.P845S|NLRP7_ENST00000590030.1_Missense_Mutation_p.P873S			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	873							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TTACAATCAGGGTAACTCAAG	0.483000													15	53					0	0	1	0	0
TRAF2	7186	broad.mit.edu	37	9	139815663	139815663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139815663C>T	ENST00000359662.3	+	9	1335	c.1290C>T	c.(1288-1290)tcC>tcT	p.S430S	TRAF2_ENST00000536468.1_Silent_p.S378S|TRAF2_ENST00000247668.2_Silent_p.S378S			Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	378	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		CCATCTTCTCCCCAGGTGTGG	0.602000													16	41					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180335746	180335746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180335746G>A	ENST00000231229.4	+	2	444	c.210G>A	c.(208-210)ggG>ggA	p.G70G	BTNL8_ENST00000400707.3_Intron|BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000340184.4_Silent_p.G70G|BTNL8_ENST00000508408.1_Silent_p.G70G	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	70	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGGGACGGGAAGGACCAGC	0.532000													65	116					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165491	172165491	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172165491T>C	ENST00000241256.2	-	1	755	c.713A>G	c.(712-714)aAg>aGg	p.K238R	GHSR_ENST00000427970.1_Missense_Mutation_p.K238R	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	238					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CCGCCACAGCTTCCTGCCGAT	0.607000													17	42					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20801637	20801637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20801637G>A	ENST00000359062.3	+	13	2621	c.2581G>A	c.(2581-2583)Gat>Aat	p.D861N	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	861	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GCTATATAACGATCGTTCAGT	0.368000													39	107					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94650952	94650952	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94650952C>T	ENST00000260526.6	-	17	2048	c.1866G>A	c.(1864-1866)acG>acA	p.T622T	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	622					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity	p.T622T(1)		NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CCCTACATTTCGTGGGGGATC	0.398000													29	95					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53639522	53639522	+	Missense_Mutation	SNP	G	G	A	rs151332923	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:53639522G>A	ENST00000262135.4	-	24	3559	c.3466C>T	c.(3466-3468)Cgc>Tgc	p.R1156C	RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.R1190C|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.R1236C|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.R1202C	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	1236					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				ACGGTGAAGCGAAGGCTGGTA	0.517000													5	65					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539929	94539929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94539929G>A	ENST00000289495.5	+	1	720	c.504G>A	c.(502-504)ggG>ggA	p.G168G	PPP1R9A_ENST00000340694.4_Silent_p.G168G|PPP1R9A_ENST00000424654.1_Silent_p.G168G|PPP1R9A_ENST00000456331.2_Silent_p.G168G|PPP1R9A_ENST00000433881.1_Silent_p.G168G|PPP1R9A_ENST00000433360.1_Silent_p.G168G	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	168						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAGCTGGAGGGAGTGAACCTC	0.493000										HNSCC(28;0.073)			35	55					0	0	1	0	0
CYB561D1	284613	broad.mit.edu	37	1	110038505	110038505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110038505C>T	ENST00000420578.2	+	3	354	c.314C>T	c.(313-315)gCt>gTt	p.A105V	CYB561D1_ENST00000496961.1_3'UTR|CYB561D1_ENST00000310611.4_3'UTR|CYB561D1_ENST00000533024.1_3'UTR|CYB561D1_ENST00000527072.1_3'UTR|CYB561D1_ENST00000430195.2_3'UTR|CYB561D1_ENST00000369868.3_Missense_Mutation_p.A127V|CYB561D1_ENST00000393709.3_Missense_Mutation_p.A48V|CYB561D1_ENST00000528785.1_Missense_Mutation_p.A105V			Q8N8Q1	C56D1_HUMAN	cytochrome b561 family, member D1	105	Cytochrome b561.				electron transport chain|transport	integral to membrane	metal ion binding			breast(1)|large_intestine(3)|prostate(1)	5		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0422)|Epithelial(280;0.0655)|all cancers(265;0.0685)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		CTCTGTGCAGCTCTGGGCCTG	0.612000													57	131					0	0	1	0	0
MFNG	4242	broad.mit.edu	37	22	37882141	37882141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37882141C>T	ENST00000356998.3	-	1	298	c.75G>A	c.(73-75)cgG>cgA	p.R25R	MFNG_ENST00000416983.3_Silent_p.R25R	NM_002405.3	NP_002396.2	O00587	MFNG_HUMAN	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	25					pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			large_intestine(2)|lung(2)|skin(1)	5	Melanoma(58;0.0574)					TCAAGTGGTACCGCAGACACA	0.667000													18	44					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108339003	108339003	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:108339003G>A	ENST00000344440.6	-	26	3377	c.3378C>T	c.(3376-3378)atC>atT	p.I1126I	SORCS1_ENST00000263054.6_Intron|SORCS1_ENST00000369698.1_Silent_p.I661I	NM_001013031.2|NM_001206569.1|NM_001206571.1|NM_001206572.1	NP_001013049.1|NP_001193498.1|NP_001193500.1|NP_001193501.1	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	1126						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TAATCCCCGGGATCTTCCTAA	0.468000													41	168					0	0	1	0	0
FAM193B	54540	broad.mit.edu	37	5	176951947	176951947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176951947G>A	ENST00000329540.5	-	9	3242	c.413C>T	c.(412-414)cCt>cTt	p.P138L	FAM193B_ENST00000443375.2_Missense_Mutation_p.P479L|FAM193B_ENST00000514747.1_Missense_Mutation_p.P512L			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	188										kidney(1)|large_intestine(3)	4						TAGACTCTGAGGCTCAGGCTC	0.557000													20	18					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201521630	201521630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:201521630G>A	ENST00000374700.2	+	27	3382	c.3141G>A	c.(3139-3141)atG>atA	p.M1047I	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	1047					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GAATTGAAATGGGGCAGGGGG	0.433000													10	84					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669549	234669549	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234669549T>A	ENST00000360418.3	+	1	616	c.616T>A	c.(616-618)Ttc>Atc	p.F206I	UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A1_ENST00000305208.5_Missense_Mutation_p.F206I|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A3_ENST00000482026.1_Intron			P22309	UD11_HUMAN		206					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	TCACATGACCTTCCTGCAGCG	0.527000													54	192					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57865728	57865728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57865728G>A	ENST00000228682.2	+	12	3296	c.3205G>A	c.(3205-3207)Ggc>Agc	p.G1069S	GLI1_ENST00000543426.1_Missense_Mutation_p.G941S|GLI1_ENST00000546141.1_Missense_Mutation_p.G1028S	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	1069					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			TGATCAGCGGGGCAGCTCTGG	0.572000													16	198					0	0	1	0	0
SERINC2	347735	broad.mit.edu	37	1	31896549	31896549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:31896549C>T	ENST00000373710.1	+	3	349	c.76C>T	c.(76-78)Ctc>Ttc	p.L26F	SERINC2_ENST00000491976.1_3'UTR|SERINC2_ENST00000536859.1_Missense_Mutation_p.L21F|SERINC2_ENST00000536384.1_Missense_Mutation_p.L21F|SERINC2_ENST00000373709.3_Missense_Mutation_p.L17F	NM_001199038.1	NP_001185967.1	Q96SA4	SERC2_HUMAN	serine incorporator 2	17						integral to membrane				cervix(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	12		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)		GGCGTCCTGCCTCTGCGGCTC	0.672000													5	44					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216420478	216420478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216420478C>T	ENST00000366943.2	-	13	2644	c.2258G>A	c.(2257-2259)gGc>gAc	p.G753D	USH2A_ENST00000307340.3_Missense_Mutation_p.G753D|USH2A_ENST00000366942.3_Missense_Mutation_p.G753D			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	753	Laminin EGF-like 5.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTCACTGAGCCATGGAGGTT	0.428000										HNSCC(13;0.011)			13	145					0	0	1	0	0
PLCD1	5333	broad.mit.edu	37	3	38065836	38065836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38065836C>T	ENST00000463876.1	-	1	442	c.89G>A	c.(88-90)cGg>cAg	p.R30Q	PLCD1_ENST00000334661.4_Intron	NM_001130964.1	NP_001124436.1	P51178	PLCD1_HUMAN	phospholipase C, delta 1	0	PH.|Substrate binding (By similarity).				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		ACCCAGCCTCCGTCCATTGAG	0.667000													15	34					0	0	1	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24523833	24523833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:24523833G>A	ENST00000376862.3	+	2	733	c.100G>A	c.(100-102)Gag>Aag	p.E34K		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	34					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						CTTGATGGCCGAGAGCAGAGA	0.552000													28	88					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25235776	25235776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:25235776G>A	ENST00000219660.5	+	4	606	c.481G>A	c.(481-483)Gag>Aag	p.E161K	AQP8_ENST00000566125.1_Missense_Mutation_p.E155K	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	161					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		GTTGGTGGCAGAGATCATCCT	0.617000													14	50					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189065209	189065209	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189065209C>T	ENST00000332517.3	+	5	918	c.778C>T	c.(778-780)Cag>Tag	p.Q260*	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	260					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		ACTCTTGCTTCAGTGTCCAGA	0.552000													8	29					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152583269	152583269	+	Silent	SNP	G	G	A	rs138173087		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152583269G>A	ENST00000367255.5	-	101	19471	c.18870C>T	c.(18868-18870)tcC>tcT	p.S6290S	SYNE1_ENST00000341594.5_Silent_p.S5902S|SYNE1_ENST00000423061.1_Silent_p.S6219S|SYNE1_ENST00000356820.4_Silent_p.S814S|SYNE1_ENST00000448038.1_Silent_p.S6219S|SYNE1_ENST00000265368.4_Silent_p.S6290S	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6290					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGTCTTCAGCGGATGATTTCT	0.393000										HNSCC(10;0.0054)			23	41					0	0	1	0	0
CLEC5A	23601	broad.mit.edu	37	7	141645147	141645147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141645147C>T	ENST00000546910.1	-	3	329	c.133G>A	c.(133-135)Gga>Aga	p.G45R	CLEC5A_ENST00000470595.1_Intron|CLEC5A_ENST00000551012.2_Missense_Mutation_p.G45R|CLEC5A_ENST00000438351.1_Missense_Mutation_p.G45R|CLEC5A_ENST00000439991.1_Missense_Mutation_p.M9I	NM_013252.2	NP_037384.1	Q9NY25	CLC5A_HUMAN	C-type lectin domain family 5, member A	45					anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	10	Melanoma(164;0.0171)					TTACCTGTTCCATAGCTCCTG	0.458000													39	59					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961675	34961675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34961675C>T	ENST00000329357.5	+	1	763	c.727C>T	c.(727-729)Cgc>Tgc	p.R243C		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	243	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCCAGAGACTCGCGCATCTCA	0.647000													7	58					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23729755	23729755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23729755C>T	ENST00000304749.2	-	2	310	c.240G>A	c.(238-240)ggG>ggA	p.G80G	CST1_ENST00000398402.1_Silent_p.G80G	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	80						extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					AGTAATTCACCCCCCCAACGG	0.557000													34	185					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119727715	119727715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:119727715G>A	ENST00000327097.4	+	3	360	c.225G>A	c.(223-225)cgG>cgA	p.R75R	MARCO_ENST00000541757.1_5'UTR	NM_006770.3	NP_006761.1	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	75					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						CGCGGCTCCGGGTCCTGGAGA	0.562000													19	75					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101818647	101818647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101818647C>T	ENST00000375001.3	+	35	3721	c.3298C>T	c.(3298-3300)Ccc>Tcc	p.P1100S		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1100	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GCCACCGGGGCCCCCGGGGCC	0.622000													13	64					0	0	1	0	0
HRASLS5	117245	broad.mit.edu	37	11	63235883	63235883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63235883C>T	ENST00000540857.1	-	4	532	c.400G>A	c.(400-402)Gag>Aag	p.E134K	HRASLS5_ENST00000539221.1_Missense_Mutation_p.E144K|HRASLS5_ENST00000301790.4_Missense_Mutation_p.E144K	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201.1|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	144										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						GCCCAGTGCTCATAGCCAATT	0.408000													44	111					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117120290	117120290	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117120290G>A	ENST00000307564.4	-	12	2811	c.2650C>T	c.(2650-2652)Caa>Taa	p.Q884*	AKNA_ENST00000374075.5_Nonsense_Mutation_p.Q803*|AKNA_ENST00000374088.3_Nonsense_Mutation_p.Q884*|AKNA_ENST00000223791.3_Nonsense_Mutation_p.Q344*	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	884					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						ATACTACTTTGGTGGGATGCT	0.647000													19	57					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095234	69095234	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69095234C>T	ENST00000332644.5	-	8	848	c.686_splice	c.e8-1	p.K229_splice		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	229	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						AATTATTTTTCCTAGAGGACA	0.323000													16	56					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55012616	55012616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:55012616G>A	ENST00000371336.3	+	2	634	c.433G>A	c.(433-435)Gaa>Aaa	p.E145K	CASS4_ENST00000360314.3_Missense_Mutation_p.E145K|CASS4_ENST00000434344.1_Missense_Mutation_p.E145K	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	145					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						AATCATCTGTGAAAAGACTCT	0.537000													59	85					0	0	1	0	0
GJB6	10804	broad.mit.edu	37	13	20797319	20797319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:20797319C>T	ENST00000356192.6	-	5	921	c.301G>A	c.(301-303)Gaa>Aaa	p.E101K	GJB6_ENST00000241124.6_Missense_Mutation_p.E101K|GJB6_ENST00000400066.3_Missense_Mutation_p.E101K|GJB6_ENST00000400065.3_Missense_Mutation_p.E101K	NM_001110219.2	NP_001103689.1	O95452	CXB6_HUMAN	gap junction protein, beta 6, 30kDa	101					cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	9		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		CGAGTGGTTTCGTGCCTGTAG	0.552000													12	41					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171520495	171520495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:171520495G>A	ENST00000176763.5	-	9	1818	c.1475C>T	c.(1474-1476)aCc>aTc	p.T492I	STK10_ENST00000517775.1_5'UTR	NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	492							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCTCTCAGAGGTGCAGAGGCT	0.597000													51	147					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358346	10358346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10358346C>T	ENST00000255381.2	-	21	2457	c.2347G>A	c.(2347-2349)Gaa>Aaa	p.E783K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	783	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GCTAGCTTTTCATCTCGCATT	0.443000													28	44					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186015882	186015882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186015882C>T	ENST00000265022.3	-	4	820	c.281G>A	c.(280-282)gGa>gAa	p.G94E	DGKG_ENST00000382164.4_Missense_Mutation_p.G94E|DGKG_ENST00000344484.4_Missense_Mutation_p.G94E|DGKG_ENST00000544847.1_Missense_Mutation_p.G94E	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	94					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	GTTGCTGGCTCCCTCCGTCGG	0.617000													22	97					0	0	1	0	0
GK5	256356	broad.mit.edu	37	3	141944199	141944199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141944199G>A	ENST00000392993.2	-	1	250	c.99C>T	c.(97-99)tgC>tgT	p.C33C	GK5_ENST00000466685.3_5'UTR|GK5_ENST00000544571.1_Silent_p.C33C	NM_001039547.2	NP_001034636.1	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	33					glycerol metabolic process		ATP binding|glycerol kinase activity			kidney(1)|large_intestine(1)|lung(7)|urinary_tract(1)	10						CATAGACGTGGCAGCGGATCA	0.701000													5	6					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69727233	69727233	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:69727233C>T	ENST00000349945.1	+	14	4775	c.3223C>T	c.(3223-3225)Cag>Tag	p.Q1075*	NFAT5_ENST00000393742.2_Nonsense_Mutation_p.Q1075*|NFAT5_ENST00000354436.2_Nonsense_Mutation_p.Q1151*|NFAT5_ENST00000566899.1_Nonsense_Mutation_p.Q1075*|NFAT5_ENST00000432919.1_Nonsense_Mutation_p.Q1169*|NFAT5_ENST00000567239.1_Nonsense_Mutation_p.Q1168*	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1151					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GAATAATCTTCAGACTAACAC	0.428000													68	152					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76417042	76417042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76417042C>T	ENST00000357063.3	+	26	5503	c.4243C>T	c.(4243-4245)Cct>Tct	p.P1415S	LMO7_ENST00000341547.4_Missense_Mutation_p.P1081S|LMO7_ENST00000377534.3_Missense_Mutation_p.P1415S|LMO7_ENST00000321797.8_Missense_Mutation_p.P1130S|LMO7_ENST00000465261.2_Missense_Mutation_p.P1130S|LMO7_ENST00000526202.1_Missense_Mutation_p.P1007S			Q8WWI1	LMO7_HUMAN	LIM domain 7	1415						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AGGTTTTCTTCCTGGTGACAG	0.328000													35	85					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103310945	103310945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103310945G>A	ENST00000233969.2	+	6	1640	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K	SLC9A2_ENST00000469286.1_3'UTR	NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	500						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						AGCTGTCAGTGAAGAAATCTA	0.363000													15	67					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26689562	26689562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26689562C>T	ENST00000436292.1	-	5	1218	c.1098G>A	c.(1096-1098)caG>caA	p.Q366Q	ZNF683_ENST00000349618.3_Silent_p.Q366Q|ZNF683_ENST00000403843.1_Silent_p.Q366Q|ZNF683_ENST00000374204.1_Silent_p.Q366Q			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGTGGTGCTTCTGCAGGTGGG	0.577000													5	15					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15967683	15967683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:15967683C>T	ENST00000350896.3	-	9	1275	c.1078G>A	c.(1078-1080)Gaa>Aaa	p.E360K	MSR1_ENST00000445506.2_Missense_Mutation_p.E441K|MSR1_ENST00000262101.5_Missense_Mutation_p.E423K|MSR1_ENST00000355282.2_Missense_Mutation_p.E360K	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	423	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATAGATGATTCTCTCCCAAAA	0.373000													49	85					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51920657	51920657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51920657C>T	ENST00000353836.5	-	2	321	c.100G>A	c.(100-102)Ggc>Agc	p.G34S	SIGLEC10_ENST00000441969.3_Missense_Mutation_p.G34S|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.G34S|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.G34S|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.G34S|CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.G34S|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.G34S|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.G34S|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.G34S	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	34	Ig-like V-type.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		ATGCACAGGCCCTCCGGCACC	0.592000													22	69					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8000065	8000065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8000065G>A	ENST00000380149.1	-	15	2514	c.2484C>T	c.(2482-2484)atC>atT	p.I828I	ALOXE3_ENST00000448843.2_Silent_p.I672I|ALOXE3_ENST00000318227.3_Silent_p.I804I			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	672					leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						GGAAGGCGGCGATGCTCCGCC	0.622000													31	45					0	0	1	0	0
TMEM67	91147	broad.mit.edu	37	8	94822081	94822081	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:94822081C>T	ENST00000453321.3	+	26	2788	c.2730C>T	c.(2728-2730)ttC>ttT	p.F910F	TMEM67_ENST00000409623.3_Silent_p.F829F	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	910					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			GAATGGAATTCATGGAACCAA	0.299000													18	54					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531463	50531463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50531463G>A	ENST00000374144.3	+	3	1161	c.873G>A	c.(871-873)aaG>aaA	p.K291K	C10orf71_ENST00000323868.4_Silent_p.K291K			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	291										endometrium(1)	1						TGGAGAGAAAGGACACAGCTG	0.537000													12	23					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166152463	166152463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166152463G>A	ENST00000375437.2	+	2	420	c.130G>A	c.(130-132)Gag>Aag	p.E44K	SCN2A_ENST00000375427.2_Missense_Mutation_p.E44K|SCN2A_ENST00000357398.3_Missense_Mutation_p.E44K|SCN2A_ENST00000283256.6_Missense_Mutation_p.E44K	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	44					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	ACGCAAGGATGAGGATGATGA	0.463000													7	47					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204002981	204002981	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:204002981C>T	ENST00000449802.1	+	29	4908	c.4575C>T	c.(4573-4575)atC>atT	p.I1525I		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1525							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TAGTGCTGATCATACAGGACT	0.373000													27	74					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067218	190067218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190067218G>A	ENST00000367462.3	-	8	2462	c.2231C>T	c.(2230-2232)tCt>tTt	p.S744F	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.S642F	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		744						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CTGCAGAGCAGATTGGATCCT	0.428000													47	109					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964202	70964202	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70964202C>T	ENST00000357250.6	-	25	1854	c.1696G>A	c.(1696-1698)Gat>Aat	p.D566N	COL9A1_ENST00000370499.4_Missense_Mutation_p.D323N|COL9A1_ENST00000320755.7_Missense_Mutation_p.D323N|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	566	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AATCCTGCATCACCAGGAGGC	0.383000													8	69					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471630	61471630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61471630G>A	ENST00000398019.2	+	8	1229	c.904G>A	c.(904-906)Gaa>Aaa	p.E302K	SERPINB7_ENST00000336429.2_Missense_Mutation_p.E302K|SERPINB7_ENST00000546027.1_Missense_Mutation_p.E302K|SERPINB7_ENST00000540675.1_Missense_Mutation_p.E285K	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	302					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				TATCTTTGATGAATCCAAAGC	0.408000													26	55					0	0	1	0	0
TBC1D20	128637	broad.mit.edu	37	20	428611	428611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:428611G>A	ENST00000354200.4	-	2	325	c.178C>T	c.(178-180)Ctc>Ttc	p.L60F		NM_144628.2	NP_653229.1	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	60	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(17;0.228)|Breast(17;0.231)				TCAGTCAGGAGCCCTCCTTCA	0.527000													18	55					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45861601	45861601	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45861601C>T	ENST00000397928.1	+	32	4858	c.4413C>T	c.(4411-4413)gcC>gcT	p.A1471A	TRPM2_ENST00000397932.2_Silent_p.A1521A|TRPM2_ENST00000300482.5_Silent_p.A1471A|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Silent_p.A1417A	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1471	Nudix hydrolase.					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ACTCGGGGGCCTCCATCCGAT	0.652000													7	36					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107703405	107703405	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107703405C>T	ENST00000388781.3	-	23	3179	c.3096G>A	c.(3094-3096)atG>atA	p.M1032I	LAMB4_ENST00000205386.4_Missense_Mutation_p.M1032I|LAMB4_ENST00000388780.3_Missense_Mutation_p.M1032I	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1032	Laminin EGF-like 11.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GGGGACACTCCATGGGACTCA	0.532000													18	39					0	0	1	0	0
QRFPR	84109	broad.mit.edu	37	4	122250756	122250756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122250756C>T	ENST00000394427.2	-	6	1420	c.1009G>A	c.(1009-1011)Gaa>Aaa	p.E337K	QRFPR_ENST00000334383.5_3'UTR	NM_198179.2	NP_937822.2	Q96P65	QRFPR_HUMAN	pyroglutamylated RFamide peptide receptor	337						plasma membrane	neuropeptide Y receptor activity			endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(2)|skin(3)|stomach(1)	28						TTGAAGTTTTCATTCATAAAT	0.323000													13	46					0	0	1	0	0
RGL4	266747	broad.mit.edu	37	22	24036125	24036125	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24036125G>A	ENST00000290691.5	+	4	2046	c.876G>A	c.(874-876)agG>agA	p.R292R	RGL4_ENST00000401461.1_Silent_p.R156R	NM_153615.1	NP_705843.1	Q8IZJ4	RGDSR_HUMAN	ral guanine nucleotide dissociation stimulator-like 4	292	Ras-GEF.				small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle	guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(3)	15						CCCGGGACAGGGCCAGGGTGG	0.592000													27	61					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003966	57003966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57003966C>T	ENST00000606794.1	-	1	709	c.513G>A	c.(511-513)ggG>ggA	p.G171G		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	171						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TCTCCAAGTCCCCGGTGGTGC	0.647000													18	45					0	0	1	0	0
FIZ1	84922	broad.mit.edu	37	19	56109072	56109072	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56109072G>A	ENST00000221665.3	-	2	249	c.160C>T	c.(160-162)Ccg>Tcg	p.P54S	FIZ1_ENST00000592585.1_Intron	NM_032836.2	NP_116225.2	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)	11			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CCGCAGCGCGGACATGCGTGG	0.657000													12	99					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74640034	74640034	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74640034T>A	ENST00000253159.8	+	25	4758	c.4560T>A	c.(4558-4560)tcT>tcA	p.S1520S	ZNF236_ENST00000320610.9_Silent_p.S1522S	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1520					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCTCGGGGTCTCCACAGGAAA	0.498000													6	48					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209782374	209782374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209782374G>A	ENST00000009105.1	+	8	930	c.685G>A	c.(685-687)Gag>Aag	p.E229K	CAMK1G_ENST00000361322.2_Missense_Mutation_p.E229K|CAMK1G_ENST00000494990.1_3'UTR			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	229	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		TAAGCTTTTCGAGAAGATCAA	0.493000													55	120					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79429952	79429952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79429952C>T	ENST00000264895.6	+	63	10012	c.9572C>T	c.(9571-9573)tCc>tTc	p.S3191F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3186					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						AAATCCCCCTCCCCAGGCTAC	0.542000													4	27					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119934770	119934770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119934770G>A	ENST00000361035.4	+	7	1131	c.848G>A	c.(847-849)gGg>gAg	p.G283E	HAO2_ENST00000325945.3_Missense_Mutation_p.G270E	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	270	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		GCTGTAAAGGGGAAAATTGAA	0.488000													15	65					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51693415	51693415	+	Silent	SNP	C	C	T	rs150740618	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51693415C>T	ENST00000267012.4	-	6	553	c.492G>A	c.(490-492)aaG>aaA	p.K164K	BIN2_ENST00000544402.1_Silent_p.K138K|BIN2_ENST00000452142.2_Silent_p.K132K|BIN2_ENST00000604560.1_Silent_p.K137K	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	164	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						CCTCATCTTTCTTCTTGGCAT	0.517000													73	142					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756558	248756558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248756558G>A	ENST00000330500.2	-	1	542	c.512C>T	c.(511-513)tCc>tTc	p.S171F		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AATCTCATGGGATCTGCAGAA	0.507000													28	117					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489273	237489273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237489273C>T	ENST00000272928.3	+	2	475	c.165C>T	c.(163-165)ttC>ttT	p.F55F		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		TTTTCATCTTCGTCATCGGCA	0.522000													4	22					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42327846	42327846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42327846C>T	ENST00000262418.6	-	20	2871	c.2716G>A	c.(2716-2718)Gaa>Aaa	p.E906K		NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	906	Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		ATGGCCACTTCGTCGTATTCA	0.597000													17	21					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052500	15052500	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15052500C>G	ENST00000248072.3	+	1	200	c.200C>G	c.(199-201)tCc>tGc	p.S67C		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TCCAACCTGTCCTTTGCTGAC	0.483000													17	77					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275650	152275650	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152275650G>A	ENST00000368799.1	-	3	11747	c.11712C>T	c.(11710-11712)tcC>tcT	p.S3904S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3904	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGCGGTGAGAGGATCCGGGGT	0.502000									Ichthyosis				30	88					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189675740	189675740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189675740C>T	ENST00000319332.5	-	15	2285	c.2088G>A	c.(2086-2088)ggG>ggA	p.G696G	LEPREL1_ENST00000427335.2_Silent_p.G515G	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	696					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GTTCATGCTTCCCTTGCTGTT	0.313000											OREG0015985	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	92					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113163237	113163237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113163237G>A	ENST00000401783.2	-	40	10055	c.9719C>T	c.(9718-9720)tCt>tTt	p.S3240F	SVEP1_ENST00000374469.1_Missense_Mutation_p.S3217F|SVEP1_ENST00000297826.5_Missense_Mutation_p.S1166F	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3240	Sushi 31.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TTTCCCACAAGAAACTGGACT	0.388000													13	40					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13601076	13601076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13601076C>T	ENST00000606117.1	+	9	1048	c.752C>T	c.(751-753)tCc>tTc	p.S251F	SIRT5_ENST00000379262.4_Missense_Mutation_p.S251F|SIRT5_ENST00000359782.3_Missense_Mutation_p.S233F|SIRT5_ENST00000397350.2_Missense_Mutation_p.S143F	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	251	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	GTGGGCACTTCCTCTGTGGTG	0.537000													7	34					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	169780949	169780949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169780949C>T	ENST00000377360.4	+	1	459	c.69C>T	c.(67-69)atC>atT	p.I23I	KCNIP1_ENST00000518527.1_3'UTR	NM_001034838.2	NP_001030010.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	0					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTAAGCTCATCACTGGGACCC	0.557000													19	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579281	179579281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179579281C>T	ENST00000589042.1	-	91	26444	c.26220G>A	c.(26218-26220)aaG>aaA	p.K8740K	TTN_ENST00000342992.6_Silent_p.K7496K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.K8423K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8423	Ig-like 70.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGAGCTTCTTCACAAATC	0.438000													11	29					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54914862	54914862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54914862C>T	ENST00000474759.1	+	21	1932	c.1884C>T	c.(1882-1884)ttC>ttT	p.F628F	CACNA2D3_ENST00000415676.2_Silent_p.F628F|CACNA2D3_ENST00000288197.5_Silent_p.F628F|CACNA2D3_ENST00000490478.1_Silent_p.F534F|CACNA2D3-AS1_ENST00000471265.1_RNA	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	628						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GGAAATATTTCTTCCGAGGGA	0.483000													94	239					0	0	1	0	0
BCL2L12	83596	broad.mit.edu	37	19	50170331	50170331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50170331C>T	ENST00000246785.3	+	3	673	c.415C>T	c.(415-417)Ccc>Tcc	p.P139S	BCL2L12_ENST00000246784.3_Intron|BCL2L12_ENST00000441864.2_Missense_Mutation_p.P138S	NM_001040668.1|NM_138639.1	NP_001035758.1|NP_619580.1	Q9HB09	B2L12_HUMAN	BCL2-like 12 (proline rich)	139					apoptosis					central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	8		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		AAGATGTCTTCCCTGCTCCCT	0.607000													28	68					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10435073	10435073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10435073C>T	ENST00000245503.5	-	22	2958	c.2574G>A	c.(2572-2574)atG>atA	p.M858I	MYH2_ENST00000397183.2_Missense_Mutation_p.M858I|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	858					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ATTCTTCCTTCATGGTGGCCA	0.423000													39	51					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38921528	38921528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38921528G>A	ENST00000302328.3	-	19	3504	c.3306C>T	c.(3304-3306)atC>atT	p.I1102I	SCN11A_ENST00000456224.3_Silent_p.I1064I|SCN11A_ENST00000444237.2_Silent_p.I1102I|SCN11A_ENST00000450244.1_Silent_p.I1102I	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1102					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCATCTCCAGGATAAAAATAT	0.348000													17	34					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542092	55542092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55542092G>A	ENST00000220676.1	+	4	5798	c.5650G>A	c.(5650-5652)Gat>Aat	p.D1884N		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1884					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGTCTCTGATGATGCTATTAA	0.408000													30	80					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88423632	88423632	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88423632G>A	ENST00000394480.1	-	18	2482	c.2161C>T	c.(2161-2163)Cgc>Tgc	p.R721C	NTRK3_ENST00000357724.2_Missense_Mutation_p.R727C|NTRK3_ENST00000355254.2_Missense_Mutation_p.R721C|NTRK3_ENST00000360948.2_Missense_Mutation_p.R735C|NTRK3_ENST00000557856.1_Missense_Mutation_p.R713C	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	735	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.R721F(1)	ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGCATCCAGCGAATGGGGAGC	0.507000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			32	47					0	0	1	0	0
G3BP2	9908	broad.mit.edu	37	4	76571592	76571592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76571592C>T	ENST00000359707.4	-	11	1891	c.1106G>A	c.(1105-1107)gGa>gAa	p.G369E	G3BP2_ENST00000357854.3_Missense_Mutation_p.G336E|G3BP2_ENST00000395719.3_Missense_Mutation_p.G369E	NM_203505.2	NP_987101.1	Q9UN86	G3BP2_HUMAN	GTPase activating protein (SH3 domain) binding protein 2	369	RRM.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	27			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TGGAAGCTTTCCCCCAACACC	0.348000													68	176					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987944	50987944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50987944G>A	ENST00000395676.2	+	1	1483	c.1349G>A	c.(1348-1350)gGg>gAg	p.G450E		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	450										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCTGCCGTGGGGACATCTAC	0.672000													32	79					0	0	1	0	0
KCNE3	10008	broad.mit.edu	37	11	74168606	74168606	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74168606C>T	ENST00000310128.4	-	3	422	c.3G>A	c.(1-3)atG>atA	p.M1I	RP11-702H23.4_ENST00000533008.1_RNA|KCNE3_ENST00000525550.1_Start_Codon_SNP_p.M1I	NM_005472.4	NP_005463.1	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related family, member 3	1						integral to membrane	voltage-gated potassium channel activity			cervix(1)|large_intestine(1)|lung(1)|ovary(1)	4	Breast(11;2.86e-06)					TGGTAGTCTCCATAGCAACAG	0.542000													19	64					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674678	167674678	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167674678C>T	ENST00000519204.1	+	26	6489	c.6371C>T	c.(6370-6372)cCc>cTc	p.P2124L	TENM2_ENST00000403607.2_Missense_Mutation_p.P2069L|TENM2_ENST00000545108.1_Missense_Mutation_p.P2244L|TENM2_ENST00000518659.1_Missense_Mutation_p.P2245L|TENM2_ENST00000520394.1_Missense_Mutation_p.P2006L					teneurin transmembrane protein 2																		CGCCTCATGCCCTTGCGCTAT	0.557000													12	35					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	39966963	39966963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39966963G>A	ENST00000336649.4	+	1	206	c.206G>A	c.(205-207)cGg>cAg	p.R69Q	CACNA1I_ENST00000404898.1_Missense_Mutation_p.R69Q|CACNA1I_ENST00000402142.3_Missense_Mutation_p.R69Q|CACNA1I_ENST00000401624.1_Missense_Mutation_p.R69Q|CACNA1I_ENST00000400164.3_Missense_Mutation_p.R69Q|CACNA1I_ENST00000407673.1_Missense_Mutation_p.R69Q			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	69					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ACCAGCCCCCGGAACTGGTGC	0.637000													8	127					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74401595	74401595	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74401595G>A	ENST00000319380.7	-	2	541	c.477_splice	c.e2+1	p.T159_splice		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	159							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						CAGGACTCACGGTGGATCGCA	0.602000													4	10					0	0	1	0	0
MYCL	4610	broad.mit.edu	37	1	40363568	40363568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40363568C>T	ENST00000397332.2	-	3	785	c.661G>A	c.(661-663)Gtg>Atg	p.V221M	MYCL_ENST00000372816.2_Missense_Mutation_p.V191M|RP1-118J21.5_ENST00000418255.1_RNA	NM_001033081.2|NM_001033082.2	NP_001028253.1|NP_001028254.2			v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog																		TCTGCTCGCACCGTGATGGTG	0.502000													22	91					0	0	1	0	0
TNP2	7142	broad.mit.edu	37	16	11361859	11361859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11361859G>A	ENST00000312693.3	-	2	480	c.411C>T	c.(409-411)tcC>tcT	p.S137S	RMI2_ENST00000572173.1_Intron	NM_005425.4	NP_005416.1	Q05952	STP2_HUMAN	transition protein 2 (during histone to protamine replacement)	137					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding	p.0?(1)		large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6						CTCATTAGTTGGATTTCCATC	0.443000													8	12					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287790	16287790	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:16287790G>A	ENST00000343518.6	-	1	147	c.96C>T	c.(94-96)ttC>ttT	p.F32F		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	32										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TGCACCAGGCGAAGCAGTGGC	0.582000													93	264					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186006591	186006591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186006591G>A	ENST00000265022.3	-	6	991	c.452C>T	c.(451-453)tCt>tTt	p.S151F	DGKG_ENST00000382164.4_Missense_Mutation_p.S151F|DGKG_ENST00000344484.4_Missense_Mutation_p.S151F|DGKG_ENST00000544847.1_Missense_Mutation_p.S151F	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	151	Poly-Ser.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CGAGCTTGAAGACCGAGGGAC	0.552000													110	264					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75408420	75408420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75408420C>T	ENST00000394810.2	-	4	1139	c.990G>A	c.(988-990)acG>acA	p.T330T	SYNPO2L_ENST00000372873.4_Silent_p.T106T|SYNPO2L_ENST00000372872.4_Silent_p.T330T	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	330						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					CGGACTCACTCGTGGGGGGAA	0.607000													25	62					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36051420	36051420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36051420G>A	ENST00000262623.3	-	6	660	c.632C>T	c.(631-633)cCc>cTc	p.P211L		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	211					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GATGTCGGCGGGCACTCTGTC	0.627000													9	61					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119926576	119926576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119926576C>T	ENST00000327554.2	+	5	927	c.462C>T	c.(460-462)ttC>ttT	p.F154F	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	154										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		AGCCCCTCTTCCGCCAGCTCT	0.517000													23	55					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58207538	58207538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58207538G>A	ENST00000302572.2	-	1	108	c.87C>T	c.(85-87)ttC>ttT	p.F29F		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGATGAAAAGGAAGACTATGA	0.458000													25	89					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19206957	19206957	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19206957C>T	ENST00000318596.7	+	2	175	c.24C>T	c.(22-24)ggC>ggT	p.G8G		NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	8					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			TGAAGGAAGGCCCGGTGCGAT	0.612000													10	27					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139277969	139277969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139277969G>A	ENST00000395297.1	-	4	444	c.274C>T	c.(274-276)Cat>Tat	p.H92Y		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	92										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AAGAGTAAATGAACTCGGAAG	0.473000										HNSCC(54;0.14)			28	70					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935937	30935937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30935937G>A	ENST00000355537.3	+	2	1615	c.1468G>A	c.(1468-1470)Gga>Aga	p.G490R		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTCCCTCCTGGGATGCCTCAA	0.657000													26	54					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7169850	7169850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7169850C>T	ENST00000406697.1	+	6	705	c.77C>T	c.(76-78)cCt>cTt	p.P26L	C1S_ENST00000328916.3_Missense_Mutation_p.P26L|C1S_ENST00000402681.3_Intron|C1S_ENST00000360817.5_Missense_Mutation_p.P26L			P09871	C1S_HUMAN	complement component 1, s subcomponent	26	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	ATCCTGTCCCCTAACTATCCT	0.473000													17	83					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167039	140167039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140167039C>T	ENST00000504120.2	+	1	1164	c.1164C>T	c.(1162-1164)tcC>tcT	p.S388S	PCDHA1_ENST00000378133.3_Silent_p.S388S|PCDHA1_ENST00000394633.3_Silent_p.S388S	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACTTGCTCCTTAATGCCCC	0.567000													61	116					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55331371	55331371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55331371C>T	ENST00000391728.4	+	4	592	c.559C>T	c.(559-561)Ctt>Ttt	p.L187F	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.L187F|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.L187F|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.L187F|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.L187F|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.L92F	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		TCCCATGATGCTTGCCCTTGC	0.547000													38	140					0	0	1	0	0
HIST1H4F	8361	broad.mit.edu	37	6	26240738	26240738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26240738G>A	ENST00000377745.2	+	1	178	c.85G>A	c.(85-87)Ggc>Agc	p.G29S		NM_003540.3	NP_003531.1	P62805	H4_HUMAN	histone cluster 1, H4f	29					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CAACATACAGGGCATCACGAA	0.557000													9	34					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56737280	56737280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56737280G>A	ENST00000314128.4	-	24	2472	c.2449C>T	c.(2449-2451)Ccg>Tcg	p.P817S	STAT2_ENST00000556539.1_5'UTR|STAT2_ENST00000557235.1_Missense_Mutation_p.P813S			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	817					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						TCACCATTCGGCATGATTTCT	0.507000													26	42					0	0	1	0	0
NCF4	4689	broad.mit.edu	37	22	37272064	37272064	+	Missense_Mutation	SNP	C	C	T	rs146292447		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37272064C>T	ENST00000397147.4	+	8	1181	c.997C>T	c.(997-999)Ccc>Tcc	p.P333S	NCF4_ENST00000248899.6_Intron	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	0					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						GCCTGTCACCCCCTTAGGGAC	0.617000													12	34					0	0	1	0	0
GABBR1	2550	broad.mit.edu	37	6	29595317	29595317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29595317G>A	ENST00000377034.4	-	6	938	c.603C>T	c.(601-603)agC>agT	p.S201S	GABBR1_ENST00000377016.4_Silent_p.S139S|GABBR1_ENST00000376977.3_Silent_p.S201S|GABBR1_ENST00000377012.4_Silent_p.S84S|GABBR1_ENST00000355973.3_Silent_p.S84S	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	201					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	TGTCCCTGCGGCTATTCACGT	0.677000													8	11					0	0	1	0	0
NAIF1	203245	broad.mit.edu	37	9	130825767	130825767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130825767G>A	ENST00000373078.4	-	2	1143	c.924C>T	c.(922-924)gcC>gcT	p.A308A	NAIF1_ENST00000488519.1_5'UTR	NM_197956.3	NP_931045.1	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	308					apoptosis|induction of apoptosis	nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CAGAGGCGGGGGCCGGGTTAG	0.627000													25	90					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634069	32634069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32634069G>A	ENST00000242310.4	-	1	1598	c.1509C>T	c.(1507-1509)atC>atT	p.I503I	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	503					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CATCCCAAATGATATTGTCCT	0.478000													36	130					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117977565	117977565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117977565G>A	ENST00000425217.1	-	10	1613	c.1559C>T	c.(1558-1560)tCc>tTc	p.S520F	KSR2_ENST00000302438.5_Missense_Mutation_p.S246F|KSR2_ENST00000339824.5_Missense_Mutation_p.S549F|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	549	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity	p.S581F(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCACTGTGGGGAAGGGTGTAG	0.642000													7	34					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133883780	133883780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133883780G>A	ENST00000220616.4	+	4	502	c.462G>A	c.(460-462)ctG>ctA	p.L154L	TG_ENST00000377869.1_Silent_p.L154L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	154	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCCGCCAGCTGGGGAGGCCAA	0.592000													13	20					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47876552	47876552	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47876552G>A	ENST00000289672.2	-	37	5960	c.5910C>T	c.(5908-5910)ctC>ctT	p.L1970L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1970					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CCAGGGCAGTGAGACACGCGT	0.602000													9	27					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788484	42788484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42788484C>T	ENST00000372980.3	-	2	1815	c.943G>A	c.(943-945)Gag>Aag	p.E315K		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	315					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CACTCGCCCTCGTAGCGGAGG	0.657000													20	33					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17230663	17230663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17230663G>A	ENST00000180173.5	-	2	145	c.111C>T	c.(109-111)ttC>ttT	p.F37F	MTMR7_ENST00000521857.1_Silent_p.F37F	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	37							protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		AATTTTCCACGAATATGACAT	0.403000													8	37					0	0	1	0	0
SCARF2	91179	broad.mit.edu	37	22	20779730	20779730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20779730G>A	ENST00000405555.3	-	11	2603	c.2533C>T	c.(2533-2535)Ccg>Tcg	p.P845S	SCARF2_ENST00000266214.5_Missense_Mutation_p.P850S	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	846	Pro-rich.				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TTGCGCGGCGGCTTCTGGATG	0.756000													5	16					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72889588	72889588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:72889588C>T	ENST00000264839.7	+	5	782	c.782C>T	c.(781-783)tCc>tTc	p.S261F	RIMS1_ENST00000348717.5_Missense_Mutation_p.S261F|RIMS1_ENST00000517960.1_Missense_Mutation_p.S261F|RIMS1_ENST00000491071.2_Missense_Mutation_p.S261F|RIMS1_ENST00000522291.1_Missense_Mutation_p.S261F|RIMS1_ENST00000521978.1_Missense_Mutation_p.S261F|RIMS1_ENST00000520567.1_Missense_Mutation_p.S261F|RIMS1_ENST00000518273.1_Missense_Mutation_p.S261F			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	261					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAGGCTTCATCCAGGTCTAGA	0.527000													6	11					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186059893	186059893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186059893C>T	ENST00000271588.4	+	64	9960	c.9731C>T	c.(9730-9732)cCt>cTt	p.P3244L	HMCN1_ENST00000367492.2_Missense_Mutation_p.P3244L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3244					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCCAAAGTTCCTCCAAGTGTT	0.358000													22	72					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208835	58208835	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58208835C>T	ENST00000377918.3	+	1	2181	c.2155C>T	c.(2155-2157)Ctc>Ttc	p.L719F		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	719					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CTCCATCATCCTCCTAGCGGC	0.607000													19	68					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5770965	5770965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5770965G>A	ENST00000381624.3	+	19	1706	c.1645G>A	c.(1645-1647)Gac>Aac	p.D549N	CATSPERD_ENST00000309164.7_3'UTR|CATSPERD_ENST00000381614.2_Missense_Mutation_p.D207N	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	549						integral to membrane											GGAATTCTACGACCCCGGCTT	0.547000													30	72					0	0	1	0	0
CKMT1A	548596	broad.mit.edu	37	15	43990917	43990917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43990917G>A	ENST00000413453.2	+	8	1614	c.1090G>A	c.(1090-1092)Ggc>Agc	p.G364S	CKMT1A_ENST00000434505.1_Missense_Mutation_p.G364S|STRC_ENST00000541030.1_Intron			P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1A	364	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity			lung(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	TGCTGCCACAGGCGGTGTCTT	0.502000													49	83					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54362336	54362336	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:54362336C>T	ENST00000306888.2	-	5	1167	c.916G>A	c.(916-918)Gat>Aat	p.D306N	FIP1L1_ENST00000507166.1_Intron|LNX1_ENST00000263925.7_Missense_Mutation_p.D402N	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	402	PDZ 1.					cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			CCAGGCTCATCCACCTTGCGC	0.522000													14	171					0	0	1	0	0
APOA5	116519	broad.mit.edu	37	11	116661629	116661629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:116661629G>A	ENST00000542499.1	-	4	388	c.316C>T	c.(316-318)Cgc>Tgc	p.R106C	APOA5_ENST00000227665.4_Missense_Mutation_p.R106C	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	106					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		GGCTGGAGGCGAGCCTTCACC	0.642000													29	79					0	0	1	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32713033	32713033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32713033G>A	ENST00000374940.3	+	2	282	c.180G>A	c.(178-180)gtG>gtA	p.V60V		NM_020056.4	NP_064440.1	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ alpha 2	60	Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			endometrium(2)|large_intestine(3)|lung(7)|skin(1)	13					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGTTCTATGTGGACCTGGAGA	0.483000													48	170					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1081113	1081113	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1081113A>G	ENST00000441003.2	+	11	1436	c.1409A>G	c.(1408-1410)gAg>gGg	p.E470G	MUC2_ENST00000359061.5_Missense_Mutation_p.E470G	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	470	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CTGCTCAACGAGCTGCAGGTG	0.667000													8	45					0	0	1	0	0
IGLV7-43	28776	broad.mit.edu	37	22	22749721	22749721	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22749721G>A	ENST00000390298.2	+	0	279																											ACCCCTGCCCGGTTCTCAGGC	0.547000													31	40					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	136969778	136969778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:136969778C>T	ENST00000508657.1	-	12	2016	c.1302G>A	c.(1300-1302)gcG>gcA	p.A434A	KLHL3_ENST00000506873.1_5'UTR|KLHL3_ENST00000506491.1_Silent_p.A384A|KLHL3_ENST00000309755.4_Silent_p.A466A|KLHL3_ENST00000541417.1_Intron	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	466						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		ATTCATTGGTCGCTGGGTTGT	0.552000													23	124					0	0	1	0	0
DOK4	55715	broad.mit.edu	37	16	57507918	57507918	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57507918G>A	ENST00000566936.1	-	6	930	c.633C>T	c.(631-633)ttC>ttT	p.F211F	DOK4_ENST00000569548.1_Silent_p.F211F|DOK4_ENST00000340099.4_Silent_p.F211F			Q8TEW6	DOK4_HUMAN	docking protein 4	211	IRS-type PTB.						insulin receptor binding			kidney(1)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	6						CTTGTGTCTGGAAGGTATAGA	0.572000													10	70					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84553916	84553916	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84553916C>T	ENST00000286744.5	+	10	1248	c.1024C>T	c.(1024-1026)Cag>Tag	p.Q342*	ADAMTSL3_ENST00000567476.1_Nonsense_Mutation_p.Q342*	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	342						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CATCAGTCATCAGTGGAGACA	0.468000													12	48					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24528491	24528491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24528491C>T	ENST00000342740.5	+	21	1793	c.1639C>T	c.(1639-1641)Ctg>Ttg	p.L547L	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	547										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		CCTGCAGTCACTGTCGGTGGC	0.647000													15	33					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1092130	1092130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1092130G>A	ENST00000441003.2	+	30	3976	c.3949G>A	c.(3949-3951)Ggc>Agc	p.G1317S	MUC2_ENST00000359061.5_Missense_Mutation_p.G1318S	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1317						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCCCAGCAGTGGCAGCGACGA	0.592000													9	21					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93499834	93499834	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93499834C>T	ENST00000394196.4	+	16	3023	c.1955C>T	c.(1954-1956)tCc>tTc	p.S652F	CHD2_ENST00000557381.1_Missense_Mutation_p.S652F	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	652	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CTTCAGAATTCCCTCAAAGAG	0.433000													47	138					0	0	1	0	0
FASTKD5	60493	broad.mit.edu	37	20	3128799	3128799	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3128799G>A	ENST00000380266.3	-	2	1239	c.918C>T	c.(916-918)atC>atT	p.I306I	UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	306					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						TATATTTAAGGATCAATGATT	0.358000													34	88					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102815	22102815	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22102815G>A	ENST00000542433.1	-	1	281	c.184C>T	c.(184-186)Cgc>Tgc	p.R62C		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TACATGGGGCGAGCACAGAGC	0.512000													30	68					0	0	1	0	0
MAB21L3	126868	broad.mit.edu	37	1	116670241	116670241	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:116670241C>T	ENST00000369500.3	+	5	901	c.636C>T	c.(634-636)tcC>tcT	p.S212S	MAB21L3_ENST00000464946.1_3'UTR	NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	212										breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						GCTGGCCTTCCCAAGAGAGAG	0.587000													9	25					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25451449	25451449	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25451449G>A	ENST00000424208.1	+	0	2384				SNHG14_ENST00000450809.1_RNA|SNORD115-20_ENST00000365099.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						GAAGAGAGGTGATGACTTAAA	0.498000													96	425					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31463235	31463235	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31463235G>A	ENST00000261592.5	-	10	1993	c.1696C>T	c.(1696-1698)Cta>Tta	p.L566L	NOL4_ENST00000269185.4_Silent_p.L350L|NOL4_ENST00000535384.1_Silent_p.L281L|NOL4_ENST00000535475.1_Silent_p.L347L|NOL4_ENST00000589544.1_Silent_p.L464L|NOL4_ENST00000538587.1_Silent_p.L492L	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	566						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TTCAGATTTAGCAGACCCCCT	0.393000													80	194					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345431	33345431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33345431G>A	ENST00000374796.2	-	8	3690	c.1120C>T	c.(1120-1122)Cct>Tct	p.P374S	NCOA6_ENST00000359003.2_Missense_Mutation_p.P374S			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	374	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|Poly-Pro.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						GGATATGGAGGGGGAGGGTGG	0.562000													54	90					0	0	1	0	0
TAS2R20	259295	broad.mit.edu	37	12	11150314	11150314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11150314G>A	ENST00000538986.1	-	1	160	c.161C>T	c.(160-162)tCc>tTc	p.S54F	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176889.2	NP_795370.2	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	54					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						ACCAACTCTGGAGACTGCCAG	0.348000													34	68					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013021	73013021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73013021C>T	ENST00000308744.6	+	4	1159	c.1061C>T	c.(1060-1062)cCt>cTt	p.P354L	NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000395999.1_Missense_Mutation_p.P255L|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000358749.3_Missense_Mutation_p.P252L	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	354					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GCTGCAGTTCCTCACACAGGC	0.498000													28	64					0	0	1	0	0
TJP2	9414	broad.mit.edu	37	9	71833266	71833266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71833266C>T	ENST00000377245.4	+	4	541	c.333C>T	c.(331-333)gtC>gtT	p.V111V	TJP2_ENST00000348208.4_Silent_p.V111V|TJP2_ENST00000377259.1_Silent_p.V88V|TJP2_ENST00000539225.1_Silent_p.V142V|TJP2_ENST00000265384.7_Silent_p.V111V|TJP2_ENST00000535702.1_Silent_p.V115V|TJP2_ENST00000453658.2_Silent_p.V88V	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	111	PDZ 1.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						GTGGGAAGGTCGCTGCTATTG	0.433000													25	46					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8130997	8130997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8130997C>T	ENST00000600128.1	-	64	8650	c.8236G>A	c.(8236-8238)Gag>Aag	p.E2746K	FBN3_ENST00000601739.1_Missense_Mutation_p.E2746K|FBN3_ENST00000270509.2_Missense_Mutation_p.E2746K			Q75N90	FBN3_HUMAN	fibrillin 3	2746						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AAACCTTGCTCGTTTCCGCGG	0.687000													30	91					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2886878	2886878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2886878C>T	ENST00000520002.1	-	52	8376	c.7821G>A	c.(7819-7821)ggG>ggA	p.G2607G	CSMD1_ENST00000542608.1_Silent_p.G2606G|CSMD1_ENST00000537824.1_Silent_p.G2606G|CSMD1_ENST00000602723.1_Silent_p.G2607G|CSMD1_ENST00000400186.3_Silent_p.G2607G|CSMD1_ENST00000602557.1_Silent_p.G2607G			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2607	Sushi 16.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTTCCACGTCCCATTGGCCT	0.517000													5	24					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63174098	63174098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63174098G>A	ENST00000279178.3	+	7	1452	c.1203G>A	c.(1201-1203)ctG>ctA	p.L401L	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	401					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						CTTGGGCACTGAAATACATGA	0.483000													10	100					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062045	9062045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9062045G>A	ENST00000397910.4	-	3	25604	c.25401C>T	c.(25399-25401)ttC>ttT	p.F8467F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8469	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGATATGGTGAACTGATCAG	0.493000													48	185					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117929	20117929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20117929C>T	ENST00000397165.2	-	4	542	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	ZNF682_ENST00000358523.5_Missense_Mutation_p.E96K|ZNF682_ENST00000595736.1_Missense_Mutation_p.E52K|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000593468.1_3'UTR|ZNF682_ENST00000397162.1_Missense_Mutation_p.E96K|ZNF682_ENST00000597972.1_Missense_Mutation_p.E134K	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TTATAAATTTCTTTTTGATCC	0.328000													25	55					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6063514	6063514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6063514C>T	ENST00000379959.3	-	4	683	c.510G>A	c.(508-510)atG>atA	p.M170I	IL2RA_ENST00000256876.6_Missense_Mutation_p.M170I|IL2RA_ENST00000379954.1_Intron	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	170	Sushi 2.				cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TCCCGTGGGTCATTTTGCAGA	0.537000													54	144					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94048819	94048819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94048819G>A	ENST00000297268.6	+	34	2506	c.2035G>A	c.(2035-2037)Ggt>Agt	p.G679S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	679			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGGTGCTCCTGGTGCTGTAGG	0.453000										HNSCC(75;0.22)			23	56					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109779736	109779736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109779736C>T	ENST00000356711.2	+	31	3949	c.3823C>T	c.(3823-3825)Cct>Tct	p.P1275S	MYO16_ENST00000457511.2_Missense_Mutation_p.P787S|MYO16_ENST00000357550.2_Missense_Mutation_p.P1275S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1275					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CATCTGGTCTCCTTCGCTGCA	0.642000													9	18					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42830653	42830653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42830653G>A	ENST00000398600.2	+	19	2982	c.1957G>A	c.(1957-1959)Gct>Act	p.A653T	MX1_ENST00000455164.2_Missense_Mutation_p.A653T|MX1_ENST00000398598.3_Missense_Mutation_p.A653T|MX1_ENST00000288383.6_Missense_Mutation_p.A630T	NM_001144925.1	NP_001138397.1	P20591	MX1_HUMAN	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	653	GED.				induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GCTGACGCAGGCTCGGCGCCG	0.652000													8	54					0	0	1	0	0
C9orf173	441476	broad.mit.edu	37	9	140146307	140146307	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140146307G>A	ENST00000388931.3	+	2	254	c.228G>A	c.(226-228)caG>caA	p.Q76Q	C9orf173_ENST00000412566.1_Silent_p.Q76Q	NM_001004353.3|NM_001256699.1|NM_001256700.1|NM_001256701.1	NP_001004353.2|NP_001243628.1|NP_001243629.1|NP_001243630.1	Q8N7X2	CI173_HUMAN	chromosome 9 open reading frame 173	76										kidney(1)|large_intestine(1)|lung(5)|pancreas(1)	8						GCACCCCCCAGGAGTCCCTGC	0.647000													4	8					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76414572	76414572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76414572C>T	ENST00000357063.3	+	23	4939	c.3679C>T	c.(3679-3681)Caa>Taa	p.Q1227*	LMO7_ENST00000341547.4_Nonsense_Mutation_p.Q893*|LMO7_ENST00000377534.3_Nonsense_Mutation_p.Q1227*|LMO7_ENST00000321797.8_Nonsense_Mutation_p.Q942*|LMO7_ENST00000465261.2_Nonsense_Mutation_p.Q942*|LMO7_ENST00000526202.1_Nonsense_Mutation_p.Q819*			Q8WWI1	LMO7_HUMAN	LIM domain 7	1227						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GGTGTGGGATCAAGAGGAGGA	0.527000													14	32					0	0	1	0	0
PPP2R3B	28227	broad.mit.edu	37	X	295177	295177	+	Silent	SNP	G	G	A	rs148086983	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:295177G>A	ENST00000390665.3	-	13	1671	c.1653C>T	c.(1651-1653)ttC>ttT	p.F551F		NM_013239.4	NP_037371.2	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'', beta	551					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AGGGCGCCTCGAAGAAGGGCC	0.711000													13	26					0	0	1	0	0
VGLL1	51442	broad.mit.edu	37	X	135618328	135618328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135618328G>A	ENST00000370634.3	+	2	319	c.149G>A	c.(148-150)aGc>aAc	p.S50N		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					AGAGCTCTGAGCAATATCAAG	0.527000													22	34					0	0	1	0	0
ANTXR2	118429	broad.mit.edu	37	4	80899252	80899252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:80899252G>A	ENST00000403729.2	-	15	1781	c.1256C>T	c.(1255-1257)cCt>cTt	p.P419L	ANTXR2_ENST00000307333.7_Missense_Mutation_p.P419L|ANTXR2_ENST00000404191.1_Missense_Mutation_p.P342L|ANTXR2_ENST00000346652.6_Missense_Mutation_p.P316L	NM_058172.5	NP_477520.2	P58335	ANTR2_HUMAN	anthrax toxin receptor 2	419						endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						TGTTTCTTCAGGAATCTTCAC	0.483000									Juvenile Hyaline Fibromatosis				26	60					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10080327	10080327	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10080327C>T	ENST00000264828.3	-	56	4107	c.4022G>A	c.(4021-4023)aGg>aAg	p.R1341K		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1341	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TGGACCCGTCCTCCCTGGGGG	0.682000													6	17					0	0	1	0	0
P4HA3	283208	broad.mit.edu	37	11	73980758	73980758	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73980758G>A	ENST00000331597.4	-	11	1451	c.1406C>T	c.(1405-1407)tCg>tTg	p.S469L	P4HA3_ENST00000427714.2_Missense_Mutation_p.S469L	NM_182904.3	NP_878907.1	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha polypeptide III	469	Fe2OG dioxygenase.					endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(1)	15	Breast(11;2.31e-05)					AGCTTCCACCGAGCTCAGCTA	0.547000													23	50					0	0	1	0	0
TPRG1	285386	broad.mit.edu	37	3	188956533	188956533	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:188956533G>A	ENST00000345063.3	+	4	481	c.314G>A	c.(313-315)tGg>tAg	p.W105*	TPRG1_ENST00000433971.1_Nonsense_Mutation_p.W105*|TPRG1-AS2_ENST00000425454.1_RNA	NM_198485.3	NP_940887.1	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	105										endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|skin(2)|urinary_tract(1)	16	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		ATAGACCACTGGAACAATGAG	0.413000													45	91					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38959949	38959949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38959949C>T	ENST00000355481.4	+	27	3692	c.3561C>T	c.(3559-3561)ttC>ttT	p.F1187F	RYR1_ENST00000360985.3_Silent_p.F1187F|RYR1_ENST00000359596.3_Silent_p.F1187F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1187	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	cACCAGGCTTCCTGCCCGTCT	0.647000													28	62					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903178	6903178	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:6903178C>T	ENST00000486284.1	+	1	377	c.103C>T	c.(103-105)Cag>Tag	p.Q35*	GRM7_ENST00000357716.4_Nonsense_Mutation_p.Q35*|GRM7_ENST00000403881.1_Nonsense_Mutation_p.Q35*|GRM7_ENST00000402647.2_Nonsense_Mutation_p.Q35*|GRM7_ENST00000389336.4_Nonsense_Mutation_p.Q35*	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	35					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GGCGCGCGGCCAGGAGATGTA	0.701000													3	4					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71054852	71054852	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71054852T>A	ENST00000283228.2	-	12	2086	c.1634A>T	c.(1633-1635)aAg>aTg	p.K545M	PTPRR_ENST00000549308.1_Missense_Mutation_p.K300M|PTPRR_ENST00000537619.2_5'UTR|PTPRR_ENST00000378778.1_Missense_Mutation_p.K339M|PTPRR_ENST00000440835.2_Missense_Mutation_p.K300M|PTPRR_ENST00000342084.4_Missense_Mutation_p.K433M	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	545	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CCAGTAATGCTTCACATGTTG	0.473000													10	21					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84520207	84520207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84520207G>A	ENST00000360700.4	+	6	1748	c.862G>A	c.(862-864)Gag>Aag	p.E288K	ZNF711_ENST00000542798.1_Missense_Mutation_p.E84K|ZNF711_ENST00000373165.3_Missense_Mutation_p.E288K|ZNF711_ENST00000276123.3_Missense_Mutation_p.E288K|ZNF711_ENST00000395402.1_Missense_Mutation_p.E266K			Q9Y462	ZN711_HUMAN	zinc finger protein 711	288					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						AATGCAGCGGGAGAAGATGGT	0.418000													41	29					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2908728	2908728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:2908728C>T	ENST00000254695.8	+	15	1356	c.1266C>T	c.(1264-1266)ttC>ttT	p.F422F	RAP1GAP2_ENST00000542807.1_Silent_p.F422F|RAP1GAP2_ENST00000540393.2_Silent_p.F403F|RAP1GAP2_ENST00000366401.4_Silent_p.F407F	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	422	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						CCCCCGTTTTCCAGAAGGTAG	0.572000													24	146					0	0	1	0	0
CREB3L3	84699	broad.mit.edu	37	19	4168353	4168353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4168353G>A	ENST00000078445.2	+	6	867	c.720G>A	c.(718-720)gaG>gaA	p.E240E	CREB3L3_ENST00000602257.1_Silent_p.E238E|CREB3L3_ENST00000602147.1_Intron|CREB3L3_ENST00000252587.3_Silent_p.E180E|CREB3L3_ENST00000595923.1_Silent_p.E239E	NM_001271995.1|NM_001271996.1|NM_032607.1	NP_001258924.1|NP_001258925.1|NP_115996.1	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like 3	240					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|urinary_tract(3)	24				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCAGTACGAGGAGCGAGTGC	0.542000													8	48					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131466464	131466464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:131466464G>A	ENST00000261654.5	+	5	905	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	GPR133_ENST00000535015.1_Missense_Mutation_p.E148K	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	116					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GACACAAGGAGAACAGTCTAG	0.502000													14	83					0	0	1	0	0
MAP3K3	4215	broad.mit.edu	37	17	61735251	61735251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61735251C>T	ENST00000361357.3	+	6	776	c.458C>T	c.(457-459)tCc>tTc	p.S153F	MAP3K3_ENST00000361733.3_Missense_Mutation_p.S122F|MAP3K3_ENST00000579585.1_Missense_Mutation_p.S153F|MAP3K3_ENST00000577395.1_Missense_Mutation_p.S122F|MAP3K3_ENST00000584573.1_Missense_Mutation_p.S153F	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	122					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						TTGCTGTTGTCCCAGGACAGA	0.438000													20	61					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75022292	75022292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75022292G>A	ENST00000261978.4	-	4	1321	c.935C>T	c.(934-936)tCc>tTc	p.S312F	LTBP2_ENST00000556690.1_Missense_Mutation_p.S312F|CTD-2207P18.1_ENST00000554552.1_lincRNA|LTBP2_ENST00000557425.1_Intron	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	312					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CAGGGCGTTGGAAGAGAGCTG	0.657000													13	78					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155953	151155953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151155953G>A	ENST00000282466.3	-	6	6395	c.6396C>T	c.(6394-6396)gtC>gtT	p.V2132V	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2132	Ig-like C2-type 7.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGTTAAGTGGACCTTCATTT	0.443000													7	51					0	0	1	0	0
SLC23A1	9963	broad.mit.edu	37	5	138707942	138707942	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:138707942C>T	ENST00000353963.3	-	14	1600	c.1561_splice	c.e14-1	p.G521_splice	SLC23A1_ENST00000348729.3_Splice_Site_p.G517_splice	NM_152685.3	NP_689898.2	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 1	517					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(5)|ovary(1)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	CTCTGGGCTCCCTGGAAGAGG	0.537000													19	41					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89261523	89261523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89261523C>T	ENST00000289746.2	+	14	2470	c.2405C>T	c.(2404-2406)cCt>cTt	p.P802L		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	802					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGTCTTTCTCCTGGGGCACTG	0.687000													16	21					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65909276	65909276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:65909276C>T	ENST00000321892.4	+	13	5715	c.5654C>T	c.(5653-5655)cCt>cTt	p.P1885L	BPTF_ENST00000306378.6_Missense_Mutation_p.P1759L|BPTF_ENST00000335221.5_Missense_Mutation_p.P1885L|BPTF_ENST00000424123.3_Missense_Mutation_p.P1746L			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1885					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TATCCTTCTCCTAGACCGACC	0.373000													56	171					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204589039	204589039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204589039G>A	ENST00000367175.1	-	1	2294	c.82C>T	c.(82-84)Ccc>Tcc	p.P28S	LRRN2_ENST00000367176.3_Missense_Mutation_p.P28S|LRRN2_ENST00000496057.1_5'UTR|LRRN2_ENST00000367177.3_Missense_Mutation_p.P28S			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	28	LRRNT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GGGGGGCAGGGAACATGCCAG	0.647000													6	26					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224475603	224475603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:224475603G>A	ENST00000281701.6	-	14	1927	c.1668C>T	c.(1666-1668)ttC>ttT	p.F556F	NVL_ENST00000340871.4_Silent_p.F367F|NVL_ENST00000391875.2_Silent_p.F450F|NVL_ENST00000361463.3_Silent_p.F450F|NVL_ENST00000469075.1_Silent_p.F465F|NVL_ENST00000482491.1_Silent_p.F280F	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	556						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity	p.F556L(1)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		GAGCAACAATGAAATCATTCA	0.478000													25	56					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149129188	149129188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149129188G>A	ENST00000247930.4	-	6	2498	c.2175C>T	c.(2173-2175)ccC>ccT	p.P725P		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCTCGCACTCGGGGCACTTGA	0.672000													25	109					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52540748	52540748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52540748G>A	ENST00000321725.6	+	18	1947	c.1871G>A	c.(1870-1872)aGg>aAg	p.R624K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	624	FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCGCTGCAGAGGGTAGACGTG	0.692000													5	22					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111667826	111667826	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111667826G>A	ENST00000431670.2	+	10	2946	c.2535G>A	c.(2533-2535)acG>acA	p.T845T	PHLDB2_ENST00000393925.3_Silent_p.T845T|PHLDB2_ENST00000393923.3_Silent_p.T829T|PHLDB2_ENST00000495180.1_Intron|PHLDB2_ENST00000481953.1_Silent_p.T802T|PHLDB2_ENST00000412622.1_Silent_p.T802T	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	845						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GCAATTCCACGAATCTATCCC	0.478000													29	59					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119053036	119053036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119053036C>T	ENST00000409109.1	+	9	3175	c.2588C>T	c.(2587-2589)cCt>cTt	p.P863L	NLRX1_ENST00000525863.1_Missense_Mutation_p.P863L|NLRX1_ENST00000409265.4_Missense_Mutation_p.P863L|NLRX1_ENST00000409991.1_Missense_Mutation_p.P863L|NLRX1_ENST00000292199.2_Missense_Mutation_p.P863L|NLRX1_ENST00000469103.2_3'UTR			Q86UT6	NLRX1_HUMAN	NLR family member X1	863	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CGGGAGCACCCTTCCCTGGAA	0.637000													24	105					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46781659	46781659	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:46781659C>T	ENST00000394809.4	-	1	562	c.447G>A	c.(445-447)agG>agA	p.R149R	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	149					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GGCTGCCTCTCCTCCAGGGCA	0.667000													22	88					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100222168	100222168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:100222168G>A	ENST00000231461.5	-	3	692	c.382C>T	c.(382-384)Cta>Tta	p.L128L	ST8SIA4_ENST00000451528.2_Silent_p.L128L|ST8SIA4_ENST00000507360.2_5'UTR	NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	128					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		ACTTCAGGTAGGAGGCTATGT	0.438000													42	129					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325055	150325055	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150325055G>A	ENST00000328902.5	-	3	847	c.631C>T	c.(631-633)Caa>Taa	p.Q211*	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	211							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCTCGCAGTTGGGCCTCCTGC	0.537000													83	182					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81242165	81242165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81242165C>T	ENST00000599697.1	-	4	690	c.691G>A	c.(691-693)Gag>Aag	p.E231K	PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000337114.4_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	231	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AAGTAGGTCTCATCTGCTGCC	0.557000													9	70					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154841789	154841789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154841789C>T	ENST00000271915.3	-	1	967	c.652G>A	c.(652-654)Gag>Aag	p.E218K		NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	223						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			ATGACGATCTCCGGGGGGTTG	0.652000													31	58					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118969929	118969929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:118969929C>T	ENST00000515256.1	+	3	658	c.486C>T	c.(484-486)acC>acT	p.T162T				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	162						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						AAGAAGTGACCCTTTCTGAGG	0.517000													34	98					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100593733	100593733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100593733G>A	ENST00000471714.1	-	9	992	c.883C>T	c.(883-885)Cct>Tct	p.P295S	ABI3BP_ENST00000495063.1_Missense_Mutation_p.P295S|ABI3BP_ENST00000284322.5_Missense_Mutation_p.P295S			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	295						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						AGGGATGCAGGAAGTTTTACA	0.353000													7	14					0	0	1	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103599731	103599731	+	Silent	SNP	G	G	A	rs147415735	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103599731G>A	ENST00000560869.1	+	10	2217	c.1578G>A	c.(1576-1578)gtG>gtA	p.V526V	TNFAIP2_ENST00000538222.1_Silent_p.V9V|TNFAIP2_ENST00000451723.2_Silent_p.V195V|TNFAIP2_ENST00000333007.1_Silent_p.V526V			Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	526					angiogenesis|cell differentiation	extracellular space				NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	11		Melanoma(154;0.155)	Epithelial(46;0.191)			TGCACCTGGTGAAGGAGTACA	0.627000													18	62					0	0	1	0	0
C1orf85	112770	broad.mit.edu	37	1	156264762	156264762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156264762G>A	ENST00000362007.1	-	2	192	c.166C>T	c.(166-168)Ctg>Ttg	p.L56L	C1orf85_ENST00000472870.1_5'UTR|C1orf85_ENST00000368264.1_Intron	NM_001256604.1|NM_001256609.1|NM_144580.2	NP_001243533.1|NP_001243538.1|NP_653181.1	Q8WWB7	NCUG1_HUMAN	chromosome 1 open reading frame 85	56					positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(2)|prostate(2)|skin(3)	14	Hepatocellular(266;0.158)					ATATGAAGCAGGTTCTGCAGG	0.592000													6	42					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160431725	160431725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160431725C>T	ENST00000356956.1	+	4	569	c.421C>T	c.(421-423)Cct>Tct	p.P141S		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	141					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ATAGGGAACTCCTGAATTTGT	0.333000													21	34					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275341	71275341	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71275341T>A	ENST00000399575.2	+	3	470	c.296T>A	c.(295-297)tTt>tAt	p.F99Y	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	99	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				CCTCGACTCTTTCCGGGTTAT	0.418000													70	180					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175977	51175977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51175977G>A	ENST00000251020.4	-	2	189	c.156C>T	c.(154-156)ttC>ttT	p.F52F	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000440970.1_5'UTR	NM_002968.2	NP_002959.2	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	52					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ATAATTCAAAGAACTCGGCAC	0.453000													53	146					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092833	30092833	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30092833G>A	ENST00000567636.1	+	0	1208					NR_003558.1																						GGAGGGACGGGAAGTAGAGGA	0.423000													14	84					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926082	70926082	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70926082G>A	ENST00000603540.1	+	2	2124	c.1866G>A	c.(1864-1866)aaG>aaA	p.K622K	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Silent_p.K622K	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	622	Cys-rich.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCATCCATAAGAAGTGTGTCA	0.453000													12	90					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3740730	3740730	+	Silent	SNP	C	C	T	rs139746746	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3740730C>T	ENST00000541714.2	+	14	2274	c.1812C>T	c.(1810-1812)taC>taT	p.Y604Y	TJP3_ENST00000262968.9_Silent_p.Y637Y|TJP3_ENST00000587686.1_Silent_p.Y623Y|TJP3_ENST00000589378.1_Silent_p.Y613Y|TJP3_ENST00000539908.2_Silent_p.Y568Y|TJP3_ENST00000382008.3_Silent_p.Y618Y	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	618	Guanylate kinase-like.					tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGCCGCTACCCGCCCTACG	0.667000													12	32					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55614869	55614869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55614869C>T	ENST00000326258.1	+	1	61	c.61C>T	c.(61-63)Ccc>Tcc	p.P21S		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						TACAAACAACCCCGAGATGCA	0.373000													33	233					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138713209	138713209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138713209G>A	ENST00000389532.4	-	11	3362	c.3298C>T	c.(3298-3300)Cgt>Tgt	p.R1100C	CAMSAP1_ENST00000312405.6_Missense_Mutation_p.R822C|CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.R1111C	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	1100						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CTTCCGGAACGGGAATTCCGG	0.642000													15	37					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35801080	35801080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35801080C>T	ENST00000342694.2	+	7	1620	c.1365C>T	c.(1363-1365)acC>acT	p.T455T		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	455					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CACTTTCAACCCTGGCAATTG	0.507000													51	144					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854466	12854466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12854466G>A	ENST00000332296.7	+	3	793	c.690G>A	c.(688-690)gaG>gaA	p.E230E		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	230										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTGAAGGAGATGAAGAATC	0.418000													30	657					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107979316	107979316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:107979316C>T	ENST00000370068.1	+	7	2131	c.1285C>T	c.(1285-1287)Cat>Tat	p.H429Y	NTNG1_ENST00000370073.2_Missense_Mutation_p.H429Y|NTNG1_ENST00000370065.1_Intron|NTNG1_ENST00000370071.2_Intron|NTNG1_ENST00000370072.3_Intron|NTNG1_ENST00000370066.1_Intron|NTNG1_ENST00000370067.1_Intron|NTNG1_ENST00000370061.3_Missense_Mutation_p.H395Y|NTNG1_ENST00000542803.1_Missense_Mutation_p.H429Y|NTNG1_ENST00000370074.4_Intron|NTNG1_ENST00000370070.2_Intron			Q9Y2I2	NTNG1_HUMAN	netrin G1	429	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GGGCTCAATCCATGATCGTTG	0.478000													16	31					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84690161	84690161	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84690161G>A	ENST00000286744.5	+	26	4497		c.e26-1		ADAMTSL3_ENST00000567476.1_Splice_Site	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTTTCTGCAGAGCCTTTTTG	0.488000													13	206					0	0	1	0	0
TP53TG5	27296	broad.mit.edu	37	20	44004191	44004191	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44004191C>T	ENST00000372726.3	-	4	412	c.254_splice	c.e4-1	p.E86_splice	TP53TG5_ENST00000537995.1_Splice_Site_p.E70_splice|SYS1_ENST00000426004.1_3'UTR|SYS1-DBNDD2_ENST00000475242.1_Intron|TP53TG5_ENST00000494455.1_5'UTR|SYS1-DBNDD2_ENST00000452133.1_Intron	NM_014477.2	NP_055292.1	Q9Y2B4	T53G5_HUMAN	TP53 target 5	86					intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|prostate(2)|upper_aerodigestive_tract(1)	12						GCACTGTTTTCCCTGGCAGGG	0.512000													52	144					0	0	1	0	0
MFGE8	4240	broad.mit.edu	37	15	89442993	89442993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89442993G>A	ENST00000539437.1	-	8	1032	c.896C>T	c.(895-897)gCc>gTc	p.A299V	MFGE8_ENST00000268151.7_Intron|MFGE8_ENST00000542878.1_Missense_Mutation_p.A263V|MFGE8_ENST00000268150.8_Missense_Mutation_p.A307V|MFGE8_ENST00000566497.1_Missense_Mutation_p.A307V			Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein	307	F5/8 type C 2.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	22	Lung NSC(78;0.0392)|all_lung(78;0.077)					AAAGTTACGGGCCCCCTGGGT	0.547000													28	41					0	0	1	0	0
IGLV3-22	28795	broad.mit.edu	37	22	23047198	23047198	+	RNA	SNP	G	G	A	rs149986188	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23047198G>A	ENST00000390307.2	+	0	300																											ATCCCTGAACGATTCTCTGGG	0.552000													9	46					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21235332	21235332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21235332G>A	ENST00000233242.1	-	26	4535	c.4408C>T	c.(4408-4410)Cat>Tat	p.H1470Y		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1470					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GAGTCCAAATGAACTGAAGCA	0.403000													26	80					0	0	1	0	0
GATA2	2624	broad.mit.edu	37	3	128200709	128200709	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:128200709C>T	ENST00000341105.2	-	5	1427	c.1096G>A	c.(1096-1098)Ggg>Agg	p.G366R	GATA2_ENST00000487848.1_Missense_Mutation_p.G366R|GATA2_ENST00000489987.1_5'UTR|GATA2_ENST00000430265.2_Missense_Mutation_p.G352R	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	366					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		ACAGGGTCCCCGTTGGCGTTT	0.652000			Mis		AML(CML blast transformation)								19	49					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52942981	52942981	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52942981C>T	ENST00000354452.3	-	10	1269	c.658G>A	c.(658-660)Ggc>Agc	p.G220S	TCF4_ENST00000570177.2_Missense_Mutation_p.G90S|TCF4_ENST00000564403.2_Missense_Mutation_p.G226S|TCF4_ENST00000564999.1_Missense_Mutation_p.G220S|TCF4_ENST00000537856.3_Missense_Mutation_p.G90S|TCF4_ENST00000564228.1_Missense_Mutation_p.G149S|TCF4_ENST00000537578.1_Missense_Mutation_p.G196S|TCF4_ENST00000568673.1_Missense_Mutation_p.G196S|TCF4_ENST00000457482.3_Missense_Mutation_p.G60S|TCF4_ENST00000563760.1_5'UTR|TCF4_ENST00000570287.2_Missense_Mutation_p.G60S|TCF4_ENST00000568740.1_Missense_Mutation_p.G195S|TCF4_ENST00000544241.2_Missense_Mutation_p.G149S|TCF4_ENST00000540999.1_Missense_Mutation_p.G196S|TCF4_ENST00000356073.4_Missense_Mutation_p.G220S|TCF4_ENST00000561831.3_Missense_Mutation_p.G60S|TCF4_ENST00000543082.1_Missense_Mutation_p.G178S|TCF4_ENST00000567880.1_Missense_Mutation_p.G160S|TCF4_ENST00000398339.1_Missense_Mutation_p.G322S|TCF4_ENST00000566286.1_Missense_Mutation_p.G218S|TCF4_ENST00000565018.2_Missense_Mutation_p.G220S|TCF4_ENST00000561992.1_Missense_Mutation_p.G90S|TCF4_ENST00000566279.1_Missense_Mutation_p.G160S	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	220					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		CTGTGATGGCCATCTGTAAAG	0.463000													24	157					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50503243	50503243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50503243G>A	ENST00000301149.3	+	8	1223	c.991G>A	c.(991-993)Gag>Aag	p.E331K	GPD1_ENST00000548814.1_Missense_Mutation_p.E308K	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	331					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity	p.E331K(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	GGTGTGCTACGAGGGCCAGCC	0.572000													8	63					0	0	1	0	0
JMY	133746	broad.mit.edu	37	5	78608307	78608307	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78608307C>T	ENST00000396137.4	+	8	2512	c.2050C>T	c.(2050-2052)Cga>Tga	p.R684*	JMY_ENST00000412001.1_Intron	NM_152405.4	NP_689618.4	Q8N9B5	JMY_HUMAN	junction mediating and regulatory protein, p53 cofactor	684					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|urinary_tract(1)	16		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		GGATAGACTTCGAACATTTAA	0.303000													24	94					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37741779	37741779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37741779C>T	ENST00000400485.1	+	15	2189	c.2113C>T	c.(2113-2115)Ctt>Ttt	p.L705F	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	705					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						CCAGCTACTCCTTGTCACTGA	0.378000													25	76					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936978	15936978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:15936978G>A	ENST00000504595.1	+	4	1640	c.1159G>A	c.(1159-1161)Gag>Aag	p.E387K	FBXL7_ENST00000329673.7_Missense_Mutation_p.E375K|FBXL7_ENST00000510662.1_Missense_Mutation_p.E340K	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	387					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GAGGGGCTGCGAGGGCATCAC	0.617000													7	23					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118997857	118997857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:118997857C>T	ENST00000328252.3	+	7	3042	c.2673C>T	c.(2671-2673)gaC>gaT	p.D891D	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	891					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TGGTCCGGGACCCTCCTCTCC	0.502000													10	91					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600924	29600924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29600924G>A	ENST00000431530.3	+	1	2177	c.2119G>A	c.(2119-2121)Gag>Aag	p.E707K		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	697	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CAACCTCTATGAGAAATTCAA	0.542000													24	41					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89854724	89854724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:89854724G>A	ENST00000287908.3	+	2	721	c.328G>A	c.(328-330)Ggt>Agt	p.G110S	STEAP2_ENST00000394621.2_Missense_Mutation_p.G110S|STEAP2_ENST00000394622.2_Missense_Mutation_p.G110S|STEAP2_ENST00000394626.1_Missense_Mutation_p.G110S|STEAP2_ENST00000394632.1_Missense_Mutation_p.G110S|STEAP2_ENST00000402625.2_Missense_Mutation_p.G110S|STEAP2_ENST00000394629.2_Missense_Mutation_p.G110S	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	110					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					TCTGCTTGTGGGTAAAATCCT	0.378000													70	142					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32595760	32595760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32595760G>A	ENST00000286827.3	-	9	2428	c.1957C>T	c.(1957-1959)Cgc>Tgc	p.R653C	TIAM1_ENST00000541036.1_Missense_Mutation_p.R653C|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	653					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						ATTCCAAGGCGGCCCATGGCC	0.483000													35	76					0	0	1	0	0
TEKT4	150483	broad.mit.edu	37	2	95540633	95540633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95540633G>A	ENST00000295201.4	+	4	963	c.826G>A	c.(826-828)Gac>Aac	p.D276N	AC097374.2_ENST00000568768.1_RNA	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	276					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						CATCCTTCGCGACACCTCCGA	0.687000													3	15					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386285	56386285	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56386285C>T	ENST00000355701.3	-	22	5218	c.4348G>A	c.(4348-4350)Ggt>Agt	p.G1450S	BZRAP1_ENST00000268893.6_Missense_Mutation_p.G1390S|BZRAP1_ENST00000343736.4_Missense_Mutation_p.G1450S	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1450						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGAGGCCACCCCTCTCCCGT	0.697000													23	45					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75157303	75157303	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:75157303A>T	ENST00000342232.4	-	4	1406	c.1366T>A	c.(1366-1368)Tat>Aat	p.Y456N		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	456					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CCTTTGCGATAAAAATGAGGA	0.483000													15	116					0	0	1	0	0
OLFML3	56944	broad.mit.edu	37	1	114523091	114523091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114523091C>T	ENST00000369551.1	+	3	480	c.192C>T	c.(190-192)tcC>tcT	p.S64S	OLFML3_ENST00000491700.1_3'UTR|OLFML3_ENST00000393300.2_Silent_p.S64S|OLFML3_ENST00000320334.4_Silent_p.S84S			Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3	84					multicellular organismal development	extracellular region				breast(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)|urinary_tract(1)	14	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACACCATCTCCGGGAGAGTGG	0.587000													14	79					0	0	1	0	0
LOC100505782	100505782	broad.mit.edu	37	17	39566079	39566079	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39566079C>T	ENST00000432258.1	+	0	1493				AC003958.2_ENST00000430006.1_RNA																							CACTTGGCTCCTTCCCATCCC	0.522000													5	23					0	0	1	0	0
PAX2	5076	broad.mit.edu	37	10	102584735	102584735	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102584735A>G	ENST00000370296.2	+	10	1717	c.1167A>G	c.(1165-1167)caA>caG	p.Q389Q	PAX2_ENST00000428433.1_Intron|PAX2_ENST00000355243.3_Intron|PAX2_ENST00000361791.3_Silent_p.Q366Q|PAX2_ENST00000556085.1_Intron			Q02962	PAX2_HUMAN	paired box 2	0					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		CTTGTGTGCAACCCACTGTAT	0.617000													20	77					0	0	1	0	0
LAMP1	3916	broad.mit.edu	37	13	113973850	113973850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113973850C>T	ENST00000332556.4	+	5	823	c.629C>T	c.(628-630)cCc>cTc	p.P210L	LAMP1_ENST00000397181.3_Missense_Mutation_p.P157L	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	210	Hinge.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			AGCCCCTCGCCCTCACCCGTG	0.657000													19	51					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5069154	5069154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:5069154C>T	ENST00000381652.3	+	11	1953	c.1459C>T	c.(1459-1461)Cgc>Tgc	p.R487C	JAK2_ENST00000544510.1_Missense_Mutation_p.R338C|JAK2_ENST00000539801.1_Missense_Mutation_p.R487C	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	487					actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		GGAAACTGTTCGCTCAGACAA	0.338000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				26	46					0	0	1	0	0
PAX2	5076	broad.mit.edu	37	10	102584704	102584704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102584704G>A	ENST00000370296.2	+	10	1686	c.1136G>A	c.(1135-1137)aGg>aAg	p.R379K	PAX2_ENST00000428433.1_Intron|PAX2_ENST00000355243.3_Intron|PAX2_ENST00000361791.3_Missense_Mutation_p.R356K|PAX2_ENST00000556085.1_Intron			Q02962	PAX2_HUMAN	paired box 2	0					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		AAGCCGGGGAGGAAGCTTGCA	0.602000													36	78					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451910	138451910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138451910G>A	ENST00000344876.4	-	1	1719	c.1333C>T	c.(1333-1335)Ctc>Ttc	p.L445F	PCDH18_ENST00000412923.2_Missense_Mutation_p.L445F|PCDH18_ENST00000507846.1_Missense_Mutation_p.L225F|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	445	Cadherin 4.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ACTGTAGAGAGACTGGGTGTC	0.363000													53	124					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164733803	164733803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164733803G>A	ENST00000264382.3	-	32	3887	c.3825C>T	c.(3823-3825)ttC>ttT	p.F1275F		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1275	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GAAGGTCCTGGAATGCTTCAC	0.373000										HNSCC(35;0.089)			61	146					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204937936	204937936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204937936G>A	ENST00000367172.4	+	10	1157	c.829G>A	c.(829-831)Gac>Aac	p.D277N	NFASC_ENST00000404076.1_Missense_Mutation_p.D271N|NFASC_ENST00000513543.1_Missense_Mutation_p.D288N|NFASC_ENST00000367171.4_Missense_Mutation_p.D277N|NFASC_ENST00000403080.1_Missense_Mutation_p.D277N|NFASC_ENST00000339876.6_Missense_Mutation_p.D277N|NFASC_ENST00000539706.1_Missense_Mutation_p.D288N|NFASC_ENST00000404907.1_Missense_Mutation_p.D288N|NFASC_ENST00000360049.4_Missense_Mutation_p.D288N|NFASC_ENST00000367170.4_Missense_Mutation_p.D277N|NFASC_ENST00000401399.1_Missense_Mutation_p.D277N|NFASC_ENST00000367169.4_Missense_Mutation_p.D277N|NFASC_ENST00000338586.6_Missense_Mutation_p.D277N|NFASC_ENST00000338515.6_Missense_Mutation_p.D277N			O94856	NFASC_HUMAN	neurofascin	277	Ig-like C2-type 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCCAACACCAGACATCGCATG	0.493000													10	28					0	0	1	0	0
RORA	6095	broad.mit.edu	37	15	60919446	60919446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:60919446C>T	ENST00000261523.5	-	1	216	c.128G>A	c.(127-129)gGa>gAa	p.G43E	RORA_ENST00000335670.6_Intron|RORA_ENST00000560004.1_Intron|RP11-219B17.1_ENST00000559824.1_RNA|RORA_ENST00000309157.4_Missense_Mutation_p.G43E|RP11-219B17.1_ENST00000558235.1_RNA	NM_134260.2	NP_599022.1	P35398	RORA_HUMAN	RAR-related orphan receptor A	43	Modulating.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.G43K(1)		endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	21						ccttctggCTCCTTCACCTGC	0.537000													6	70					0	0	1	0	0
DYRK3	8444	broad.mit.edu	37	1	206821945	206821945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206821945C>T	ENST00000367106.1	+	4	1815	c.1342C>T	c.(1342-1344)Cgc>Tgc	p.R448C	DYRK3_ENST00000367108.3_Missense_Mutation_p.R448C|DYRK3_ENST00000367109.2_Missense_Mutation_p.R468C|DYRK3_ENST00000489878.1_Intron			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	468	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TGTGGGGGGTCGCTCACGTAG	0.522000													71	188					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72960115	72960115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:72960115G>A	ENST00000264839.7	+	13	2324	c.2324G>A	c.(2323-2325)gGa>gAa	p.G775E	RIMS1_ENST00000348717.5_Missense_Mutation_p.G775E|RIMS1_ENST00000517827.1_Missense_Mutation_p.G234E|RIMS1_ENST00000517960.1_Missense_Mutation_p.G775E|RIMS1_ENST00000491071.2_Missense_Mutation_p.G775E|RIMS1_ENST00000522291.1_Missense_Mutation_p.G775E|RIMS1_ENST00000401910.3_Missense_Mutation_p.G249E|RIMS1_ENST00000425662.2_Missense_Mutation_p.G168E|RIMS1_ENST00000523963.1_Missense_Mutation_p.G249E|RIMS1_ENST00000521978.1_Missense_Mutation_p.G775E|RIMS1_ENST00000520567.1_Missense_Mutation_p.G775E|RIMS1_ENST00000518273.1_Missense_Mutation_p.G775E			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	775	C2 1.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AGAGTAGATGGACGTCCTCGA	0.348000													9	19					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4925457	4925457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:4925457C>T	ENST00000333703.4	+	4	1073	c.560C>T	c.(559-561)cCt>cTt	p.P187L	PCDH11Y_ENST00000215473.6_Missense_Mutation_p.P198L|PCDH11Y_ENST00000362095.5_Missense_Mutation_p.P198L	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	198	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GCTGTTGATCCTGACGTAGGC	0.348000													42	29					0	0	1	0	0
HIATL1	84641	broad.mit.edu	37	9	97191504	97191504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:97191504C>T	ENST00000375344.3	+	3	507	c.238C>T	c.(238-240)Ctc>Ttc	p.L80F	HIATL1_ENST00000428393.2_Missense_Mutation_p.L15F	NM_032558.2	NP_115947.2	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	80					transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	11		Acute lymphoblastic leukemia(62;0.136)				ACACACATTCCTCATGAATGG	0.318000													9	23					0	0	1	0	0
ALKBH3	221120	broad.mit.edu	37	11	43923211	43923211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:43923211C>T	ENST00000302708.4	+	8	1016	c.605C>T	c.(604-606)cCc>cTc	p.P202L	ALKBH3_ENST00000532410.1_Intron	NM_139178.3	NP_631917.1	Q96Q83	ALKB3_HUMAN	alkB, alkylation repair homolog 3 (E. coli)	202	Fe2OG dioxygenase.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|kidney(1)|lung(4)|prostate(1)	8					Vitamin C(DB00126)	GGGAGGTGCCCCATTATTGCT	0.478000								Direct reversal of damage					33	46					0	0	1	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200819244	200819244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200819244C>T	ENST00000358823.2	+	11	3617	c.3347C>T	c.(3346-3348)tCc>tTc	p.S1116F	CAMSAP2_ENST00000236925.4_Missense_Mutation_p.S1127F|CAMSAP2_ENST00000413307.2_Missense_Mutation_p.S1100F	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	1127						cytoplasm|microtubule	protein binding										ATTGAAGTTTCCCTCTCAGAT	0.413000													63	115					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69027999	69027999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:69027999C>T	ENST00000288368.4	+	26	3435	c.3158C>T	c.(3157-3159)tCa>tTa	p.S1053L		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1053					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CTTCTGTCTTCAATAACATAT	0.338000													7	43					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35716442	35716442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:35716442C>T	ENST00000540320.1	+	18	2907	c.2373C>T	c.(2371-2373)ttC>ttT	p.F791F	NBEA_ENST00000379939.2_Silent_p.F791F|NBEA_ENST00000310336.4_Silent_p.F791F|NBEA_ENST00000400445.3_Silent_p.F791F			Q8NFP9	NBEA_HUMAN	neurobeachin	791						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATAGTCTTTTCACTCTTCTTG	0.368000													25	97					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179302048	179302048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179302048G>A	ENST00000356834.3	-	12	2077	c.2040C>T	c.(2038-2040)ccC>ccT	p.P680P	TBC1D9B_ENST00000355235.3_Silent_p.P680P	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	680	Rab-GAP TBC.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGCTCTCGAAGGGCATGACGC	0.607000													30	71					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183774774	183774774	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183774774C>T	ENST00000318351.1	+	5	535	c.501C>T	c.(499-501)ttC>ttT	p.F167F		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	167						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TGGACATCTTCTACTTCCCTT	0.443000													18	271					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84778340	84778340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84778340C>T	ENST00000219473.7	+	4	366	c.253C>T	c.(253-255)Cct>Tct	p.P85S	USP10_ENST00000562743.1_3'UTR|USP10_ENST00000570191.1_Missense_Mutation_p.P89S	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	85	Interaction with p53/TP53.				DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						CACACTGAACCCTCAGGCCCC	0.463000													36	58					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769160	247769160	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247769160G>A	ENST00000320002.2	+	1	305	c.273G>A	c.(271-273)acG>acA	p.T91T	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CAAAGAAGACGATCACTTACG	0.463000													36	359					0	0	1	0	0
DNAJC3	5611	broad.mit.edu	37	13	96361519	96361519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:96361519C>T	ENST00000602402.1	+	2	238	c.121C>T	c.(121-123)Ctt>Ttt	p.L41F	DNAJC3_ENST00000376795.6_Missense_Mutation_p.L41F	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	41					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding			NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			TGAGAAACATCTTGAATTGGG	0.353000													24	78					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	871741	871741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:871741G>A	ENST00000316157.3	-	11	1235	c.1195C>T	c.(1195-1197)Cct>Tct	p.P399S		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	399							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						GAAGTCAGAGGAGACGCCGCA	0.468000													7	36					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331666	70331666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70331666G>A	ENST00000338508.4	-	32	4734	c.4735C>T	c.(4735-4737)Ccc>Tcc	p.P1579S	SHANK2_ENST00000449833.2_Missense_Mutation_p.P983S|SHANK2_ENST00000423696.2_Missense_Mutation_p.P1199S|SHANK2_ENST00000409161.1_Missense_Mutation_p.P982S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1199					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			gcgggcggggggATAACAAAG	0.572000													77	102					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55684615	55684615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55684615C>T	ENST00000370830.3	-	2	1219	c.521G>A	c.(520-522)cGa>cAa	p.R174Q	BMP5_ENST00000446683.2_Missense_Mutation_p.R174Q	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	174					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GTAATGCCTTCGCTGGTGAGA	0.378000													22	63					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106321130	106321130	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106321130C>T	ENST00000390559.2	-	0	858																											ATGCTGGCCTCACCCACGGCG	0.612000													10	28					0	0	1	0	0
IPMK	253430	broad.mit.edu	37	10	59956189	59956189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:59956189G>A	ENST00000373935.3	-	6	1221	c.899C>T	c.(898-900)tCc>tTc	p.S300F		NM_152230.4	NP_689416.1	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	300						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)	22						ATTAGCTGTGGAACTTAACAC	0.368000													27	123					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9014585	9014585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9014585C>T	ENST00000397910.4	-	31	38593	c.38390G>A	c.(38389-38391)gGc>gAc	p.G12797D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12799	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTTTGATGCCATTGGTCAG	0.557000													47	181					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16740853	16740853	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:16740853C>T	ENST00000381323.3	-	10	932	c.710_splice	c.e10-1	p.E238_splice	FAM49A_ENST00000406434.1_Splice_Site_p.E238_splice|FAM49A_ENST00000355549.2_Splice_Site_p.E238_splice	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	238						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			CTTCTGTACTCCCTGCAAGAG	0.502000													28	82					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136561642	136561642	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136561642C>T	ENST00000264162.2	-	11	4531	c.4521G>A	c.(4519-4521)gaG>gaA	p.E1507E		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1507	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGGTCTCATTCTCCCAGCCTC	0.517000													25	72					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137702101	137702101	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137702101G>A	ENST00000371817.3	+	44	3889	c.3474_splice	c.e44-1	p.G1159_splice		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1159	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTTCCCCTAGGGAGAGATCGG	0.567000													20	70					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36269678	36269678	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36269678C>T	ENST00000394571.2	+	6	816	c.816C>T	c.(814-816)ttC>ttT	p.F272F	PNPLA1_ENST00000388715.3_Silent_p.F177F|PNPLA1_ENST00000312917.5_Silent_p.F186F	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	272					lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						GAGTGATTTTCCCCCGGGTGG	0.517000											OREG0017382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	66					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160721144	160721144	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:160721144A>G	ENST00000274547.2	-	11	1700	c.1483T>C	c.(1483-1485)Ttc>Ctc	p.F495L	GABRB2_ENST00000517547.1_Missense_Mutation_p.F297L|GABRB2_ENST00000520240.1_Missense_Mutation_p.F457L|GABRB2_ENST00000517901.1_Missense_Mutation_p.F394L|GABRB2_ENST00000353437.6_Missense_Mutation_p.F457L|GABRB2_ENST00000393959.1_Missense_Mutation_p.F495L	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	495					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACCACTGGGAAGAATATGCGG	0.463000													30	73					0	0	1	0	0
WASF3	10810	broad.mit.edu	37	13	27256866	27256866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:27256866C>T	ENST00000361042.4	+	9	1322	c.1097C>T	c.(1096-1098)cCc>cTc	p.P366L	WASF3_ENST00000335327.5_Missense_Mutation_p.P369L			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	369					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CCCATGCAGCCCCCGTTCCCT	0.662000													8	126					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176675568	176675568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176675568G>A	ENST00000367662.3	+	10	4603	c.3439G>A	c.(3439-3441)Gaa>Aaa	p.E1147K		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1147					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGAGCTGGAGGAAGGTTTCAA	0.413000													16	48					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21607050	21607050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21607050C>T	ENST00000392288.2	+	4	1698	c.1589C>T	c.(1588-1590)tCa>tTa	p.S530L	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Missense_Mutation_p.S402L	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						AAACGATCTTCAACCCTTACT	0.348000													15	58					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46797278	46797278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46797278C>T	ENST00000230588.4	+	10	1123	c.1114C>T	c.(1114-1116)Cgc>Tgc	p.R372C		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	372	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			AGGCAATGTTCGCAAGTTGGT	0.488000													36	136					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5757925	5757925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5757925G>A	ENST00000381624.3	+	14	1411	c.1350G>A	c.(1348-1350)ggG>ggA	p.G450G	CATSPERD_ENST00000309164.7_3'UTR|CATSPERD_ENST00000381614.2_Silent_p.G108G	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	450						integral to membrane											CATCAGATGGGAACACCAAGT	0.567000													18	37					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14769773	14769773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14769773G>A	ENST00000380881.4	-	28	5971	c.5156C>T	c.(5155-5157)aCc>aTc	p.T1719I	FREM1_ENST00000380894.1_Missense_Mutation_p.T254I|FREM1_ENST00000422223.2_Missense_Mutation_p.T1718I|FREM1_ENST00000380880.3_Missense_Mutation_p.T1718I|FREM1_ENST00000486223.1_5'UTR			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1718					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AAATTCCACGGTATCTGAATT	0.353000													15	12					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10753686	10753686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10753686G>A	ENST00000586078.1	+	22	2237	c.2128G>A	c.(2128-2130)Gag>Aag	p.E710K	SLC44A2_ENST00000407327.4_Intron|SLC44A2_ENST00000335757.5_Intron	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	0					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GGCAGAAGCCGAGGAGTAGAG	0.627000													8	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498050	179498050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179498050C>T	ENST00000589042.1	-	233	43174	c.42950G>A	c.(42949-42951)cGa>cAa	p.R14317Q	TTN_ENST00000342992.6_Missense_Mutation_p.R11749Q|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R5252Q|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R5444Q|TTN_ENST00000359218.5_Missense_Mutation_p.R5377Q|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R12676Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12676							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTATTAGTCGAGCTGAAAT	0.398000													13	170					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72363848	72363848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72363848C>T	ENST00000335666.4	+	1	252	c.204C>T	c.(202-204)ctC>ctT	p.L68L		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	68						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						GCTGGGACCTCCGAATAAGGC	0.552000													7	34					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10429970	10429970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10429970C>T	ENST00000397077.1	-	8	1473	c.898G>A	c.(898-900)Gac>Aac	p.D300N	ATP2B2_ENST00000352432.4_Missense_Mutation_p.D300N|ATP2B2_ENST00000343816.4_Missense_Mutation_p.D300N|ATP2B2_ENST00000383800.4_Missense_Mutation_p.D300N|ATP2B2_ENST00000360273.2_Missense_Mutation_p.D300N			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	300					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CCTTTTTTGTCTTTCTTCTCT	0.458000													31	232					0	0	1	0	0
SNAI1	6615	broad.mit.edu	37	20	48600619	48600619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:48600619C>T	ENST00000244050.2	+	2	402	c.341C>T	c.(340-342)tCc>tTc	p.S114F		NM_005985.3	NP_005976.2	O95863	SNAI1_HUMAN	snail family zinc finger 1	114					epithelial to mesenchymal transition|mesoderm formation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)	17			BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TCGTCCTTCTCCTCTACTTCA	0.632000													13	154					0	0	1	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27907940	27907940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27907940C>T	ENST00000326019.6	+	10	2194	c.1912C>T	c.(1912-1914)Cta>Tta	p.L638L		NM_018158.2	NP_060628.2	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger), member 1, adaptor protein	638						cytoplasm|nucleus	double-stranded RNA binding|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.155)					CCCTCCAACTCTAATGAGAAT	0.408000													17	103					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679639	100679639	+	Missense_Mutation	SNP	G	G	A	rs145386724		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100679639G>A	ENST00000306151.4	+	3	5006	c.4942G>A	c.(4942-4944)Gct>Act	p.A1648T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1648	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTCCTGAGGCTAGCACCCT	0.502000													131	515					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29407834	29407834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29407834C>T	ENST00000444197.2	+	1	752	c.42C>T	c.(40-42)ctC>ctT	p.L14L	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TTCTTCTTCTCGGCTTCTCCC	0.498000													8	75					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110835594	110835594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110835594G>A	ENST00000375820.4	-	27	2048	c.1927C>T	c.(1927-1929)Cct>Tct	p.P643S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	643	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGGTAAAGGAACAATTTTT	0.547000													6	29					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230589	36230589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36230589C>T	ENST00000303965.4	-	2	1009	c.520G>A	c.(520-522)Gac>Aac	p.D174N		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	174					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTAATATTGTCACTACCAAAT	0.363000													24	47					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2813223	2813223	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2813223G>A	ENST00000520002.1	-	65	10440	c.9885C>T	c.(9883-9885)ttC>ttT	p.F3295F	CSMD1_ENST00000542608.1_Silent_p.F3117F|CSMD1_ENST00000537824.1_Silent_p.F3294F|CSMD1_ENST00000602723.1_Silent_p.F3118F|CSMD1_ENST00000400186.3_Silent_p.F3118F|CSMD1_ENST00000602557.1_Silent_p.F3295F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3295	Sushi 28.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGGTGTAGCCGAAAGTAGGAA	0.502000													22	82					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39062705	39062705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39062705C>T	ENST00000355481.4	+	94	13909	c.13778C>T	c.(13777-13779)gCt>gTt	p.A4593V	RYR1_ENST00000360985.3_Missense_Mutation_p.A4593V|RYR1_ENST00000359596.3_Missense_Mutation_p.A4598V	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4598					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCTCAGCTGCTGGGGATGTG	0.602000													35	71					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60749489	60749489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60749489G>A	ENST00000303375.5	+	8	1839	c.1437G>A	c.(1435-1437)gaG>gaA	p.E479E		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	479	C-type lectin 2.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						ACAGTCTGGAGGACTGTGTCA	0.562000													40	101					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1255475	1255475	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1255475G>T	ENST00000310581.5	-	14	3141	c.3084C>A	c.(3082-3084)aaC>aaA	p.N1028K	TERT_ENST00000296820.5_3'UTR|TERT_ENST00000334602.6_Missense_Mutation_p.N965K	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	1028	CTE.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AAAATGTGGGGTTCTTCCAAA	0.557000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				8	48					1.06961e-07	1.07285e-07	1	1	0
TBC1D1	23216	broad.mit.edu	37	4	38091684	38091684	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:38091684A>T	ENST00000261439.4	+	13	2537	c.2182A>T	c.(2182-2184)Att>Ttt	p.I728F	TBC1D1_ENST00000508802.1_Missense_Mutation_p.I822F	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	728						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GCAAAAGGCTATTCTTCAACA	0.473000													11	135					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123301371	123301371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123301371G>A	ENST00000296513.2	+	3	332	c.147G>A	c.(145-147)atG>atA	p.M49I	ADAD1_ENST00000388725.2_Missense_Mutation_p.M31I|ADAD1_ENST00000388724.2_Missense_Mutation_p.M49I	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	49					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGTCCAAGATGGCATCCAAGG	0.453000													34	58					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38357230	38357230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38357230C>T	ENST00000379705.3	-	2	1098	c.241G>A	c.(241-243)Gag>Aag	p.E81K	TRPC4_ENST00000358477.2_Missense_Mutation_p.E81K|TRPC4_ENST00000447043.1_Missense_Mutation_p.E81K|TRPC4_ENST00000379673.2_Missense_Mutation_p.E81K|TRPC4_ENST00000338947.5_Missense_Mutation_p.E81K|TRPC4_ENST00000355779.2_Missense_Mutation_p.E81K|TRPC4_ENST00000379679.1_Missense_Mutation_p.E81K|TRPC4_ENST00000426868.2_Missense_Mutation_p.E81K|TRPC4_ENST00000379681.3_Missense_Mutation_p.E81K			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	81					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		tccaagttctcattttcaatt	0.373000													33	71					0	0	1	0	0
KRT16P4	339244	broad.mit.edu	37	17	18333049	18333049	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18333049G>A	ENST00000580052.1	+	0	43				KRT17P2_ENST00000326333.8_RNA																							GTGGAGATGGGCGCTGCCCCA	0.582000													21	17					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161049422	161049422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161049422G>A	ENST00000368012.3	-	2	699	c.397C>T	c.(397-399)Ccc>Tcc	p.P133S		NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	133	Ig-like V-type 1.				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTGCCGGCGGGGAAGGTGCTG	0.701000													11	18					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36564767	36564767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36564767G>A	ENST00000397799.1	-	4	739	c.515C>T	c.(514-516)cCt>cTt	p.P172L	COL8A2_ENST00000481785.1_Missense_Mutation_p.P107L|COL8A2_ENST00000303143.4_Missense_Mutation_p.P172L			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	172	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGTTTTCCAGGGATAGTAAT	0.716000													6	6					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23716293	23716293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23716293G>A	ENST00000256797.4	-	8	1077	c.909C>T	c.(907-909)ttC>ttT	p.F303F	ERN2_ENST00000457008.2_Silent_p.F255F	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	255					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GGAGGGCGAGGAAATGCAGAG	0.662000													15	66					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12343664	12343664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12343664C>T	ENST00000358136.3	+	21	5635	c.5505C>T	c.(5503-5505)atC>atT	p.I1835I	VPS13D_ENST00000356315.4_Silent_p.I1835I	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1835					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTTTTGGAATCGGCTCCACTG	0.483000													45	149					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41161881	41161881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41161881C>T	ENST00000263413.3	-	10	1636	c.1372G>A	c.(1372-1374)Gag>Aag	p.E458K	C6_ENST00000337836.5_Missense_Mutation_p.E458K|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	458	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTCCCTTTCTCCCATGCCAAA	0.428000													27	86					0	0	1	0	0
SNX5	27131	broad.mit.edu	37	20	17934726	17934726	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:17934726A>G	ENST00000377768.3	-	5	615	c.303T>C	c.(301-303)ggT>ggC	p.G101G	SNX5_ENST00000483485.1_5'UTR|SNX5_ENST00000377759.4_Silent_p.G101G	NM_152227.1	NP_689413.1	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	101	PX.|Phosphatidylinositol bisphosphate binding (By similarity).				cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	11						TCTCTCGAGGACCATCAAAGT	0.493000													62	174					0	0	1	0	0
OXTR	5021	broad.mit.edu	37	3	8794753	8794753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:8794753C>T	ENST00000316793.3	-	4	1704	c.1080G>A	c.(1078-1080)acG>acA	p.T360T	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	360					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	TGCTGGCACTCGTCTCTCCCA	0.622000													29	50					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057615	9057615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9057615G>A	ENST00000397910.4	-	3	30034	c.29831C>T	c.(29830-29832)tCc>tTc	p.S9944F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9946	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATGGATGAGGAAGAGAGCCT	0.453000													85	231					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2614040	2614040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2614040G>A	ENST00000399655.1	+	8	1411	c.1146G>A	c.(1144-1146)tgG>tgA	p.W382*	CACNA1C_ENST00000399637.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000480911.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000335762.5_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399603.1_Intron|CACNA1C_ENST00000399649.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000491104.1_Intron|CACNA1C_ENST00000399595.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399606.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399601.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399617.1_Intron|CACNA1C_ENST00000344100.3_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399621.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399629.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000327702.7_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000402845.3_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399597.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000347598.4_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000399638.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399644.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399591.1_Nonsense_Mutation_p.W382*|CACNA1C_ENST00000399634.1_Intron	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	382					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACTGGCCCTGGATCTATTTTG	0.498000													8	29					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53930377	53930377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53930377C>T	ENST00000371445.3	+	3	873	c.818C>T	c.(817-819)cCc>cTc	p.P273L		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	273	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						ccactgccgccCCTTCCACCG	0.682000													27	46					0	0	1	0	0
SUSD3	203328	broad.mit.edu	37	9	95847007	95847007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95847007C>T	ENST00000375472.3	+	5	782	c.746C>T	c.(745-747)cCc>cTc	p.P249L	SUSD3_ENST00000375469.1_Missense_Mutation_p.P236L	NM_145006.2	NP_659443.1	Q96L08	SUSD3_HUMAN	sushi domain containing 3	249						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	13						CCACAACAGCCCGCAGCATAT	0.647000													26	80					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15567435	15567435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15567435G>A	ENST00000343625.6	-	10	1534	c.1454C>T	c.(1453-1455)aCt>aTt	p.T485I	RASAL3_ENST00000595098.1_5'UTR	NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	485	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						CAGCTCCGCAGTGCCCAGGTC	0.607000													7	17					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233514953	233514953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233514953C>T	ENST00000366624.3	+	9	2462	c.2201C>T	c.(2200-2202)gCt>gTt	p.A734V	MLK4_ENST00000366622.1_Missense_Mutation_p.A180V	NM_032435.2	NP_115811.2																					GCATCGGTGGCTCTGGGACTG	0.527000													25	70					0	0	1	0	0
SLC10A7	84068	broad.mit.edu	37	4	147227087	147227087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:147227087G>A	ENST00000432059.2	-	6	753	c.507C>T	c.(505-507)atC>atT	p.I169I	SLC10A7_ENST00000264986.3_3'UTR|SLC10A7_ENST00000507030.1_Silent_p.I182I|SLC10A7_ENST00000335472.7_Silent_p.I182I|SLC10A7_ENST00000394062.3_Silent_p.I182I			Q0GE19	NTCP7_HUMAN	solute carrier family 10, member 7	182						integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|skin(1)	16	all_hematologic(180;0.151)					CCTGTCCAATGATGAGAGGAA	0.358000													9	26					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30963185	30963185	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30963185G>A	ENST00000311813.4	+	4	806	c.751G>A	c.(751-753)Gag>Aag	p.E251K	AQP1_ENST00000509504.1_Missense_Mutation_p.E428K|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Missense_Mutation_p.E200K|AQP1_ENST00000409899.1_Missense_Mutation_p.E136K|AQP1_ENST00000441328.2_Missense_Mutation_p.E168K|AQP1_ENST00000434909.2_Missense_Mutation_p.E311K	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				CGGCCAGGTGGAGGAGTATGA	0.627000													8	23					0	0	1	0	0
ATXN7L3	56970	broad.mit.edu	37	17	42274671	42274671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42274671G>A	ENST00000389384.4	-	3	589	c.281C>T	c.(280-282)gCc>gTc	p.A94V	ATXN7L3_ENST00000454077.2_Missense_Mutation_p.A94V|ATXN7L3_ENST00000593073.1_Intron	NM_001098833.1	NP_001092303.1	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3	94					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GCGGGAGGCGGCAATGCTGCG	0.597000													53	51					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1254125	1254125	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1254125C>T	ENST00000348261.5	+	10	2366	c.2118C>T	c.(2116-2118)gcC>gcT	p.A706A	CACNA1H_ENST00000565831.1_Silent_p.A706A|CACNA1H_ENST00000358590.4_Silent_p.A706A	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	706					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCACCCGTGCCCTGGAGGACC	0.672000													4	14					0	0	1	0	0
SCAMP3	10067	broad.mit.edu	37	1	155227093	155227093	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155227093G>T	ENST00000355379.3	-	6	962	c.684C>A	c.(682-684)atC>atA	p.I228I	SCAMP3_ENST00000302631.3_Silent_p.I254I|SCAMP3_ENST00000472397.1_5'UTR	NM_052837.2	NP_443069.1	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3	254					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(7)|ovary(4)|urinary_tract(1)	19	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCCAACCTGGGATACCAATGG	0.463000													8	23					1.76689e-08	1.77291e-08	1	1	0
PBX4	80714	broad.mit.edu	37	19	19681593	19681593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19681593G>A	ENST00000251203.8	-	3	529	c.243C>T	c.(241-243)ctC>ctT	p.L81L		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	81							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						CCAGCCTCAGGAGCTGGGCGT	0.572000													32	70					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804545	115804545	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115804545C>T	ENST00000369295.2	+	1	740	c.654C>T	c.(652-654)ttC>ttT	p.F218F		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	218	Agonist and antagonist binding (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	GCTGCGACTTCGTCACCAACC	0.662000													11	48					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43814059	43814059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43814059C>T	ENST00000382031.1	+	5	1133	c.1102C>T	c.(1102-1104)Cct>Tct	p.P368S	MAP1A_ENST00000300231.5_Missense_Mutation_p.P130S|MAP1A_ENST00000399453.1_Missense_Mutation_p.P130S			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	130	Lys-rich (basic).					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCTTATCTCTCCTGAGCTTGG	0.552000													30	67					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671263	39671263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39671263C>T	ENST00000398930.1	+	4	434	c.80C>T	c.(79-81)cCc>cTc	p.P27L	KCNJ15_ENST00000328656.3_Missense_Mutation_p.P27L|KCNJ15_ENST00000398934.1_Missense_Mutation_p.P27L|KCNJ15_ENST00000398932.1_Missense_Mutation_p.P27L|KCNJ15_ENST00000398938.2_Missense_Mutation_p.P27L			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	27					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						GCCAACAGACCCCGCGTCATG	0.552000													26	50					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94754660	94754660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94754660C>T	ENST00000554723.1	-	3	1493	c.1075G>A	c.(1075-1077)Gac>Aac	p.D359N	SERPINA10_ENST00000261994.4_Missense_Mutation_p.D319N|SERPINA10_ENST00000554173.1_Missense_Mutation_p.D319N|SERPINA10_ENST00000393096.1_Missense_Mutation_p.D319N			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	319					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TCCACCAAGTCTGTGGTCAGG	0.502000													11	94					0	0	1	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995648	57995648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57995648G>A	ENST00000316770.2	-	1	742	c.700C>T	c.(700-702)Cgt>Tgt	p.R234C		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				TCGGCAGAACGGATGCTCAGG	0.627000													20	47					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340778	121340778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121340778G>A	ENST00000338040.4	+	3	916	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	168					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		CAGTGTGGAGGAAATGGGAGG	0.488000													15	38					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57290234	57290234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:57290234C>T	ENST00000543872.2	+	4	2314	c.2050C>T	c.(2050-2052)Cct>Tct	p.P684S	CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000580498.1_3'UTR|SMG8_ENST00000300917.5_Missense_Mutation_p.P684S			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	684					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						AGAAAAAGAACCTCAAACCCA	0.468000													56	186					0	0	1	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39388084	39388084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39388084C>T	ENST00000402182.3	+	7	1119	c.1064C>T	c.(1063-1065)cCc>cTc	p.P355L	APOBEC3B-AS1_ENST00000513758.2_RNA|APOBEC3B_ENST00000333467.3_Missense_Mutation_p.P355L|APOBEC3B_ENST00000407298.3_Missense_Mutation_p.P330L			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	355					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					CAGGGATGTCCCTTCCAGCCC	0.617000													17	41					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879303	3879303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3879303C>T	ENST00000315677.3	-	4	1361	c.766G>A	c.(766-768)Gac>Aac	p.D256N	DLGAP1_ENST00000584874.1_Missense_Mutation_p.D256N|DLGAP1_ENST00000581527.1_Missense_Mutation_p.D256N|DLGAP1_ENST00000515196.2_Missense_Mutation_p.D256N|DLGAP1-AS3_ENST00000577649.1_RNA	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	256					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CACTTGACGTCGTTGTTGCTC	0.672000													17	51					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638207	234638207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234638207C>T	ENST00000482026.1	+	1	454	c.435C>T	c.(433-435)tcC>tcT	p.S145S	UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A9_ENST00000354728.4_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		ATGCTACTTCCTTTGATGTGG	0.448000													90	232					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118969872	118969872	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:118969872G>A	ENST00000515256.1	+	3	601	c.429G>A	c.(427-429)tgG>tgA	p.W143*				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	143						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						CTGTCTCCTGGGAGACAGAGG	0.463000													36	67					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156430	70156430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70156430C>T	ENST00000335568.5	+	5	1213	c.1211C>T	c.(1210-1212)gCt>gTt	p.A404V	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	404					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GATAACATTGCTCACATGAAG	0.453000													21	85					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170897468	170897468	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170897468T>C	ENST00000272793.5	+	32	4683	c.4633T>C	c.(4633-4635)Tta>Cta	p.L1545L	UBR3_ENST00000418381.1_Silent_p.L1545L|UBR3_ENST00000392631.1_Silent_p.L366L			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1545					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						CATCCAGATCTTAATGATGCC	0.328000													8	75					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155506871	155506871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155506871G>A	ENST00000302053.3	-	5	1788	c.1710C>T	c.(1708-1710)ttC>ttT	p.F570F	FGA_ENST00000403106.3_Silent_p.F570F	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	570					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CACGGGAAGGGAATTCAGCTA	0.428000													39	89					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2539368	2539368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2539368G>A	ENST00000358864.1	+	3	364	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	117	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CCCAAAGAGGGAAAAGGAGAT	0.652000													4	25					0	0	1	0	0
GRINA	2907	broad.mit.edu	37	8	145066418	145066418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145066418C>T	ENST00000313269.5	+	5	977	c.699C>T	c.(697-699)gtC>gtT	p.V233V	GRINA_ENST00000395068.4_Silent_p.V233V	NM_000837.1	NP_000828.1	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	233						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	9	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCAGTCGGTCCTGACCGCCA	0.627000													18	41					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79842818	79842818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:79842818C>T	ENST00000261205.4	+	11	1840	c.1183C>T	c.(1183-1185)Ctg>Ttg	p.L395L	SYT1_ENST00000393240.3_Silent_p.L395L|SYT1_ENST00000457153.2_Silent_p.L392L|RP1-78O14.1_ENST00000550268.1_lincRNA|SYT1_ENST00000552744.1_Silent_p.L395L	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	395					detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						GTCAGACATGCTGGCCAACCC	0.547000													17	39					0	0	1	0	0
WHAMM	123720	broad.mit.edu	37	15	83499448	83499448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83499448C>T	ENST00000286760.4	+	9	1838	c.1739C>T	c.(1738-1740)tCc>tTc	p.S580F		NM_001080435.1	NP_001073904.1	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi membranes and microtubules	580						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding			endometrium(6)|large_intestine(5)|lung(1)|prostate(1)	13						TTGCCAGCTTCCCACGCGGTG	0.512000													16	197					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31337958	31337958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31337958G>A	ENST00000215862.4	-	9	1795	c.432C>T	c.(430-432)ctC>ctT	p.L144L	MORC2_ENST00000397641.2_Silent_p.L206L|MORC2_ENST00000469915.1_5'UTR	NM_014941.1	NP_055756.1	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	206							ATP binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	21						CATTATCCATGAGTTTGAGAT	0.498000													61	125					0	0	1	0	0
BMP10	27302	broad.mit.edu	37	2	69093153	69093153	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69093153C>T	ENST00000295379.1	-	2	1043	c.885G>A	c.(883-885)ggG>ggA	p.G295G		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	295					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						AAGCCTCTTCCCCAGGTCCAC	0.493000													18	65					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952897	119952897	+	Silent	SNP	C	C	T	rs145945905		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119952897C>T	ENST00000307142.4	+	4	3163	c.2967C>T	c.(2965-2967)ccC>ccT	p.P989P	SYNPO2_ENST00000434046.2_Silent_p.P989P|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Silent_p.P989P	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	989						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ATGGCCTCCCCCAGAAGTCAT	0.512000													5	60					0	0	1	0	0
ADCK2	90956	broad.mit.edu	37	7	140380881	140380881	+	Missense_Mutation	SNP	C	C	T	rs138501789		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:140380881C>T	ENST00000072869.4	+	4	1427	c.1249C>T	c.(1249-1251)Ccc>Tcc	p.P417S	ADCK2_ENST00000476491.1_Missense_Mutation_p.P417S	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	417	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					GGCAGGAATTCCCGTGGACTT	0.567000													5	53					0	0	1	0	0
SPIB	6689	broad.mit.edu	37	19	50926223	50926223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50926223G>A	ENST00000595883.1	+	4	293	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K	SPIB_ENST00000596074.1_Intron|SPIB_ENST00000270632.7_Missense_Mutation_p.E90K|SPIB_ENST00000597855.1_Missense_Mutation_p.E90K|SPIB_ENST00000439922.2_Intron	NM_001243999.1|NM_001244000.1|NM_003121.4	NP_001230928.1|NP_001230929.1|NP_003112.2	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	90					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)	14		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AGGGAACCTCGAACTGGCCCC	0.642000													35	116					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61828635	61828635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61828635C>T	ENST00000280772.1	-	37	12195	c.12004G>A	c.(12004-12006)Gga>Aga	p.G4002R	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4002					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCACTAATTCCCTTAAAATAT	0.433000													65	146					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15937163	15937163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:15937163C>T	ENST00000504595.1	+	4	1825	c.1344C>T	c.(1342-1344)atC>atT	p.I448I	FBXL7_ENST00000329673.7_Silent_p.I436I|FBXL7_ENST00000510662.1_Silent_p.I401I	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	448					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GCTTGCAGATCGTGGCCGCCA	0.627000													4	41					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115986838	115986838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115986838G>A	ENST00000251864.2	+	23	3336	c.3183G>A	c.(3181-3183)atG>atA	p.M1061I	TDRD1_ENST00000369281.2_Missense_Mutation_p.M947I|TDRD1_ENST00000369282.1_Intron|TDRD1_ENST00000369280.1_Intron|TDRD1_ENST00000422662.1_Intron	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	1061					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CAGGATTAATGGAATTGAATG	0.264000													5	16					0	0	1	0	0
PCDHB17P	54661	broad.mit.edu	37	5	140537091	140537091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140537091C>T	ENST00000539533.1	+	1	1515	c.1515C>T	c.(1513-1515)gtC>gtT	p.V505V																								CCTCCCTGGTCTCCATCAACA	0.652000													58	197					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104508525	104508525	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104508525G>A	ENST00000409874.4	+	34	4022		c.e34+1		TDRD9_ENST00000339063.5_Splice_Site	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9						cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				AGCTTTTAGGGTAAGCTGTGT	0.463000													20	34					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118865121	118865121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:118865121G>A	ENST00000295622.1	+	1	125	c.85G>A	c.(85-87)Ggc>Agc	p.G29S		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	29										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		CCACACTAAGGGCCAGGAAGA	0.567000													15	36					0	0	1	0	0
HCN3	57657	broad.mit.edu	37	1	155258222	155258222	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155258222C>T	ENST00000368358.3	+	8	2301	c.2293C>T	c.(2293-2295)Ccc>Tcc	p.P765S	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	765	Pro-rich.					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCCAGCCACACCCCGGGGTCT	0.587000													7	95					0	0	1	0	0
CCDC102A	92922	broad.mit.edu	37	16	57552561	57552561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57552561C>T	ENST00000258214.2	-	5	1260	c.1014G>A	c.(1012-1014)cgG>cgA	p.R338R		NM_033212.3	NP_149989.2	Q96A19	C102A_HUMAN	coiled-coil domain containing 102A	338										endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8						CGGCCATTTTCCGGTCCATGC	0.652000													8	27					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121492935	121492935	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121492935G>A	ENST00000260197.7	+	45	6258	c.6129G>A	c.(6127-6129)tgG>tgA	p.W2043*	SORL1_ENST00000534286.1_Nonsense_Mutation_p.W953*|SORL1_ENST00000525532.1_Nonsense_Mutation_p.W987*|SORL1_ENST00000532694.1_Nonsense_Mutation_p.W889*|SORL1_ENST00000527934.1_Nonsense_Mutation_p.W658*	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2043	Fibronectin type-III 6.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTCTGTTTTGGAAAAGCCTGG	0.353000													20	55					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905628	15905628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15905628C>T	ENST00000308940.8	+	1	868	c.770C>T	c.(769-771)tCc>tTc	p.S257F		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						GGCTTTGCCTCCGTCATTTAC	0.572000													18	51					0	0	1	0	0
CRCT1	54544	broad.mit.edu	37	1	152487946	152487946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152487946C>T	ENST00000368790.3	+	2	160	c.87C>T	c.(85-87)ccC>ccT	p.P29P		NM_019060.2	NP_061933.1	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	29										lung(1)|ovary(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ccccggcgcccaccccggcgc	0.716000													3	23					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973335	29973335	+	Nonsense_Mutation	SNP	C	C	T	rs144365564	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:29973335C>T	ENST00000378993.1	+	11	2162	c.1489C>T	c.(1489-1491)Cga>Tga	p.R497*	IL1RAPL1_ENST00000302196.4_Nonsense_Mutation_p.R497*	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	497	TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						AACCAGACTTCGAAATATGCT	0.443000													38	43					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197298127	197298127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197298127C>T	ENST00000260983.2	-	2	203	c.21G>A	c.(19-21)gaG>gaA	p.E7E		NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	7					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						AAAGCAGGTGCTCCCGGGCTG	0.522000													21	53					0	0	1	0	0
BZRAP1-AS1	100506779	broad.mit.edu	37	17	56408651	56408651	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56408651C>T	ENST00000579527.1	+	0	351				BZRAP1-AS1_ENST00000580633.1_RNA|BZRAP1-AS1_ENST00000578334.1_RNA|MIR142_ENST00000384835.1_RNA|BZRAP1-AS1_ENST00000580515.1_RNA|MIR142_ENST00000579003.1_RNA																							GTTAGTAGTGCTTTCTACTTT	0.587000													14	56					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197396914	197396914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197396914C>T	ENST00000367397.1	+	3	1460	c.602C>T	c.(601-603)tCt>tTt	p.S201F	CRB1_ENST00000535699.1_Missense_Mutation_p.S751F|CRB1_ENST00000367400.3_Missense_Mutation_p.S820F|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000544212.1_Missense_Mutation_p.S301F|CRB1_ENST00000367399.2_Missense_Mutation_p.S708F			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	820	EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATTTCTGCTTCTACGTGGAAA	0.373000													14	42					0	0	1	0	0
GH1	2688	broad.mit.edu	37	17	61994690	61994690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61994690C>T	ENST00000323322.5	-	5	675	c.633G>A	c.(631-633)gtG>gtA	p.V211V	GH1_ENST00000351388.4_Silent_p.V171V|GH1_ENST00000342364.4_Silent_p.V116V|CSHL1_ENST00000392824.4_Intron|GH1_ENST00000458650.2_Silent_p.V196V	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	211					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						AGCTGCCCTCCACAGAGCGGC	0.617000													20	41					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498290	179498290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179498290C>T	ENST00000589042.1	-	232	43020	c.42796G>A	c.(42796-42798)Ggt>Agt	p.G14266S	TTN_ENST00000342992.6_Missense_Mutation_p.G11698S|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G5201S|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G5393S|TTN_ENST00000359218.5_Missense_Mutation_p.G5326S|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G12625S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12625	Fibronectin type-III 3.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCTTCACCATCTTTGAAC	0.408000													20	45					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31656616	31656616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31656616G>A	ENST00000375494.3	+	10	986	c.986G>A	c.(985-987)gGg>gAg	p.G329E		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	329					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										CAGGCCCTGGGGAAGCTGCCC	0.582000													15	47					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665948	19665948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19665948G>A	ENST00000328041.6	+	12	1464	c.1267G>A	c.(1267-1269)Gag>Aag	p.E423K		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	423	Poly-Glu.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						gaatgatgaggaggaagagga	0.527000													14	54					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52000654	52000654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52000654C>T	ENST00000291707.3	-	6	1506	c.1451G>A	c.(1450-1452)gGa>gAa	p.G484E	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.G366E	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	484					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGCTCCAGCTCCCCCGAATGC	0.567000													37	100					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887076	3887076	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3887076C>T	ENST00000319331.3	+	2	1512	c.751C>T	c.(751-753)Ctg>Ttg	p.L251L	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	251						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TGATAACAAACTGGTTAAAGT	0.403000													53	142					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10106264	10106264	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10106264T>A	ENST00000264828.3	-	16	1648	c.1563A>T	c.(1561-1563)ggA>ggT	p.G521G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	521	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGCCAGGGGGTCCATGAGGTC	0.507000													14	37					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179429682	179429682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179429682C>T	ENST00000589042.1	-	326	81401	c.81177G>A	c.(81175-81177)ctG>ctA	p.L27059L	TTN_ENST00000342992.6_Silent_p.L24491L|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Silent_p.L17994L|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.L18186L|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.L18119L|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Silent_p.L25418L|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25418	Fibronectin type-III 97.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTAGAATCCAGTGGGGCAC	0.383000													40	129					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89733119	89733119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89733119C>T	ENST00000343435.5	-	5	945	c.409G>A	c.(409-411)Ggt>Agt	p.G137S	GBP5_ENST00000370459.3_Missense_Mutation_p.G137S|RP4-620F22.2_ENST00000437128.1_RNA	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	137						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		TCGATAGCACCCTGATCAATT	0.453000													19	45					0	0	1	0	0
OR2V2	285659	broad.mit.edu	37	5	180582584	180582584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180582584C>T	ENST00000328275.1	+	1	642	c.642C>T	c.(640-642)atC>atT	p.I214I		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATTCTCCATCATCGTGGCCT	0.517000													27	205					0	0	1	0	0
NXPH1	30010	broad.mit.edu	37	7	8790865	8790865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:8790865C>T	ENST00000405863.1	+	3	1193	c.282C>T	c.(280-282)tcC>tcT	p.S94S	NXPH1_ENST00000497400.1_3'UTR|NXPH1_ENST00000602349.1_5'UTR	NM_152745.2	NP_689958.1	P58417	NXPH1_HUMAN	neurexophilin 1	94	II.					extracellular region				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|ovary(1)	17		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		TGAGGAACTCCACAGACCTTC	0.478000													20	65					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127235596	127235596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127235596C>T	ENST00000265825.5	+	2	599	c.380C>T	c.(379-381)tCc>tTc	p.S127F	FSCN3_ENST00000420086.2_5'UTR	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	127						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						TTTTGCACTTCCCACGTCCTC	0.572000													16	42					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113803686	113803686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113803686G>A	ENST00000260191.2	+	6	824	c.567G>A	c.(565-567)agG>agA	p.R189R	HTR3B_ENST00000537778.1_Silent_p.R178R	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	189					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CCTTTCTGAGGAGCCCAGAAG	0.483000													21	48					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71851671	71851671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71851671G>A	ENST00000373255.4	+	4	702	c.438G>A	c.(436-438)ggG>ggA	p.G146G		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	146	Lys-rich.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						AGAAGGGGGGGAAGAAATCCA	0.587000													18	56					0	0	1	0	0
GLT6D1	360203	broad.mit.edu	37	9	138518016	138518016	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138518016G>A	ENST00000371763.1	-	4	409	c.156C>T	c.(154-156)ctC>ctT	p.L52L		NM_182974.2	NP_892019.2	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	52					carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	15		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		GGACAGGAGCGAGCCAGTCTG	0.532000													16	66					0	0	1	0	0
CRYBG3	131544	broad.mit.edu	37	3	97596782	97596782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97596782C>T	ENST00000182096.4	+	1	964	c.900C>T	c.(898-900)tcC>tcT	p.S300S		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						AAAGTCATTCCTCAGAAAAAG	0.403000													9	98					0	0	1	0	0
CELA1	1990	broad.mit.edu	37	12	51736476	51736476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51736476G>A	ENST00000293636.1	-	4	249	c.209C>T	c.(208-210)aCt>aTt	p.T70I		NM_001971.5	NP_001962.3	Q9UNI1	CELA1_HUMAN	chymotrypsin-like elastase family, member 1	70	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15						CACGCGGAAAGTCTTCTGGCT	0.493000													11	37					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45829220	45829220	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:45829220G>A	ENST00000263736.4	-	3	145	c.83C>T	c.(82-84)tCa>tTa	p.S28L		NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	28					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGAGGCAGATGATCTAGAAGT	0.398000													36	92					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911020	230911020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230911020C>T	ENST00000295190.4	-	4	1280	c.822G>A	c.(820-822)agG>agA	p.R274R		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	274						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		ACATGTTCTTCCTGTGCCCGG	0.592000													42	92					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107038	121107038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:121107038C>T	ENST00000295228.3	+	2	858	c.812C>T	c.(811-813)tCg>tTg	p.S271L		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	271					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				GGCGAAGAGTCGCACCGGCCC	0.662000													17	94					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61843269	61843269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61843269C>T	ENST00000280772.1	-	33	4372	c.4181G>A	c.(4180-4182)aGa>aAa	p.R1394K	ANK3_ENST00000503366.1_Missense_Mutation_p.R1395K|ANK3_ENST00000373827.2_Missense_Mutation_p.R1388K|ANK3_ENST00000355288.2_Missense_Mutation_p.R528K	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1394					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AAATGGCAGTCTATTTTCTTT	0.303000													16	72					0	0	1	0	0
TRAV8-1	28685	broad.mit.edu	37	14	22265829	22265829	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22265829C>T	ENST00000390430.2	+	0	244																											AGCAGCCTCACTGGAGTTGGG	0.453000													23	179					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140615792	140615792	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140615792G>A	ENST00000526308.1	+	0	1855					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						GGACGCCAACGACAACTCGCC	0.711000													34	64					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155506994	155506994	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155506994G>A	ENST00000302053.3	-	5	1665	c.1587C>T	c.(1585-1587)ttC>ttT	p.F529F	FGA_ENST00000403106.3_Silent_p.F529F	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	529					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGAAACCTGGGAATGTTTTTC	0.473000													26	70					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184141	6184141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6184141C>T	ENST00000262450.3	-	31	4665	c.4566G>A	c.(4564-4566)ggG>ggA	p.G1522G	CHD5_ENST00000378021.1_Silent_p.G379G	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1522					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGCTGTACTTCCCGTTGACAT	0.632000													8	21					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37000603	37000603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:37000603C>T	ENST00000282516.8	+	12	3932	c.3433C>T	c.(3433-3435)Cgt>Tgt	p.R1145C	NIPBL_ENST00000448238.2_Missense_Mutation_p.R1145C	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1145					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AGGTGGTGGTCGTTATCGAAA	0.463000													18	110					0	0	1	0	0
TMEM63C	57156	broad.mit.edu	37	14	77719701	77719701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77719701C>T	ENST00000298351.4	+	23	2346	c.2202C>T	c.(2200-2202)tcC>tcT	p.S734S		NM_020431.2	NP_065164.2	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	734						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(1)	23			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		GCAGCACCTCCTCCACGCCCA	0.617000													5	16					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134968307	134968307	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134968307C>T	ENST00000398015.3	+	15	3190	c.2820C>T	c.(2818-2820)ctC>ctT	p.L940L	EPHB1_ENST00000493838.1_Silent_p.L501L	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	940	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TCACCTCCCTCCAGCTGGTCA	0.547000													11	89					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102742658	102742658	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102742658C>T	ENST00000532855.1	-	0	471							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	CCTCACGGTTCATGTCAGGTG	0.388000													9	22					0	0	1	0	0
NMNAT3	349565	broad.mit.edu	37	3	139346559	139346559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:139346559C>T	ENST00000413939.2	-	3	408	c.8G>A	c.(7-9)aGc>aAc	p.S3N	NMNAT3_ENST00000512391.1_Missense_Mutation_p.S3N|NMNAT3_ENST00000406824.1_5'UTR|NMNAT3_ENST00000511444.1_Intron|NMNAT3_ENST00000514703.1_Missense_Mutation_p.S3N|NMNAT3_ENST00000406164.1_5'UTR|NMNAT3_ENST00000339837.5_Intron|NMNAT3_ENST00000296202.7_Missense_Mutation_p.S3N	NM_001200047.1	NP_001186976.1	Q96T66	NMNA3_HUMAN	nicotinamide nucleotide adenylyltransferase 3	3					water-soluble vitamin metabolic process	cytosol|mitochondrion	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)	9						AGGTATTCGGCTCTTCATCTT	0.522000													3	15					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85260961	85260961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:85260961G>A	ENST00000266682.5	-	10	2048	c.1507C>T	c.(1507-1509)Ctt>Ttt	p.L503F	SLC6A15_ENST00000309283.7_Missense_Mutation_p.L211F|SLC6A15_ENST00000552192.1_Missense_Mutation_p.L396F	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	503					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						AATGCCAGAAGACAACAGATA	0.303000													25	63					0	0	1	0	0
S1PR3	1903	broad.mit.edu	37	9	91617111	91617111	+	Silent	SNP	C	C	T	rs138808274		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91617111C>T	ENST00000375846.3	+	1	5691	c.996C>T	c.(994-996)ctC>ctT	p.L332L	S1PR3_ENST00000358157.2_Silent_p.L332L			Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	332					anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(1)	34						AGCCTGCGCTCGACCCAAGCA	0.632000													12	44					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204043	9204043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9204043G>A	ENST00000429566.3	+	1	189	c.123G>A	c.(121-123)ggG>ggA	p.G41G		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TGGTCGTGGGGAACCTGCTCA	0.537000													37	100					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44596418	44596418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44596418C>T	ENST00000372299.3	+	3	1218	c.1160C>T	c.(1159-1161)gCt>gTt	p.A387V		NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	387					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					CCTCCTGCTGCTGGTCCTTAG	0.507000													8	72					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430251	135430251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135430251C>T	ENST00000394143.1	+	6	4677	c.4386C>T	c.(4384-4386)ttC>ttT	p.F1462F	GPR112_ENST00000370652.1_Silent_p.F1462F|GPR112_ENST00000287534.4_Silent_p.F1399F|GPR112_ENST00000394141.1_Silent_p.F1257F|GPR112_ENST00000412101.1_Silent_p.F1257F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1462					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CACAGACTTTCCCTGAGTCCT	0.423000													69	45					0	0	1	0	0
C2orf80	389073	broad.mit.edu	37	2	209045522	209045522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:209045522C>T	ENST00000341287.4	-	6	508	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	C2orf80_ENST00000451346.1_Missense_Mutation_p.E86K|C2orf80_ENST00000453017.1_Missense_Mutation_p.E105K	NM_001099334.2	NP_001092804.1	Q0P641	CB080_HUMAN	chromosome 2 open reading frame 80	105										endometrium(2)|large_intestine(3)|lung(6)|skin(2)	13						TTAAAGACTTCCTCAATCGGG	0.358000													29	84					0	0	1	0	0
DACT3	147906	broad.mit.edu	37	19	47151774	47151774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47151774G>A	ENST00000391916.2	-	4	1928	c.1855C>T	c.(1855-1857)Cgt>Tgt	p.R619C	DACT3_ENST00000300875.4_Missense_Mutation_p.R394C	NM_145056.2	NP_659493.2	Q96B18	DACT3_HUMAN	dishevelled-binding antagonist of beta-catenin 3	619										lung(1)	1		Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000173)|all cancers(93;0.000464)|Epithelial(262;0.02)|GBM - Glioblastoma multiforme(486;0.0325)		GAACCCGAACGGAAACGCAGT	0.577000													138	384					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130797667	130797667	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:130797667G>A	ENST00000509018.1	-	19	2800	c.2595C>T	c.(2593-2595)gcC>gcT	p.A865A	RAPGEF6_ENST00000296859.6_Silent_p.A865A|RAPGEF6_ENST00000308008.6_Silent_p.A865A|RAPGEF6_ENST00000512052.1_Silent_p.A580A|RAPGEF6_ENST00000307984.5_Silent_p.A870A|FNIP1_ENST00000514667.1_Silent_p.A915A|RAPGEF6_ENST00000507093.1_Silent_p.A865A	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	865	Ras-GEF.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		ACAGCTGGGTGGCCACCTCAA	0.403000													30	76					0	0	1	0	0
TMEM207	131920	broad.mit.edu	37	3	190147432	190147432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:190147432G>A	ENST00000354905.2	-	5	459	c.393C>T	c.(391-393)ggC>ggT	p.G131G		NM_207316.1	NP_997199.1	Q6UWW9	TM207_HUMAN	transmembrane protein 207	131						integral to membrane				endometrium(1)|large_intestine(2)|lung(4)	7	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)		AGCCTAAAGGGCCAAAACATG	0.408000													18	88					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169293	90169293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:90169293C>T	ENST00000333209.3	-	2	2487	c.1969G>A	c.(1969-1971)Gga>Aga	p.G657R		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	657										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGAGTGAGTCCTACCTGAGCA	0.577000													17	62					0	0	1	0	0
TCF3	6929	broad.mit.edu	37	19	1615524	1615524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1615524G>A	ENST00000395423.3	-	14	1621	c.1594C>T	c.(1594-1596)Cat>Tat	p.H532Y	TCF3_ENST00000453954.2_Intron|TCF3_ENST00000262965.5_Intron|TCF3_ENST00000588136.1_Intron|TCF3_ENST00000344749.5_Intron			P15923	TFE2_HUMAN	transcription factor 3	533					B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGGGCTATGGGGAGGGCGC	0.721000			T	"""PBX1, HLF, TFPT"""	pre B-ALL								29	64					0	0	1	0	0
FATE1	89885	broad.mit.edu	37	X	150891136	150891136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150891136G>A	ENST00000370350.3	+	5	542	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K		NM_033085.2	NP_149076.1	Q969F0	FATE1_HUMAN	fetal and adult testis expressed 1	153						endoplasmic reticulum|integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(6)|ovary(1)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CGCCCTGGAGGAACAGGGCGC	0.642000													38	23					0	0	1	0	0
GOLGA2P5	55592	broad.mit.edu	37	12	100564756	100564756	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100564756C>T	ENST00000397112.4	-	0	557					NR_036632.1															large_intestine(1)|lung(3)	4						TGGTGGCACTCTTTCTTTTCC	0.522000													32	119					0	0	1	0	0
BPIFB1	92747	broad.mit.edu	37	20	31878790	31878790	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31878790C>T	ENST00000253354.1	+	5	554	c.393C>T	c.(391-393)ttC>ttT	p.F131F		NM_033197.2	NP_149974.2	Q8TDL5	LPLC1_HUMAN	BPI fold containing family B, member 1	131						extracellular space	lipid binding										TCGTGGAGTTCCACATGACGA	0.647000													7	33					0	0	1	0	0
RBM19	9904	broad.mit.edu	37	12	114261086	114261086	+	Silent	SNP	G	G	A	rs140794490		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:114261086G>A	ENST00000545145.2	-	24	2904	c.2826C>T	c.(2824-2826)atC>atT	p.I942I	RBM19_ENST00000261741.5_Silent_p.I942I|RBM19_ENST00000392561.3_Silent_p.I942I	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	942					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GCTGCTCCAGGATCTCGTCCA	0.632000													8	55					0	0	1	0	0
UBE2F	140739	broad.mit.edu	37	2	238944540	238944540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238944540C>T	ENST00000272930.4	+	9	660	c.466C>T	c.(466-468)Cca>Tca	p.P156S	UBE2F_ENST00000414443.1_Missense_Mutation_p.P124S|UBE2F_ENST00000409633.1_Intron|UBE2F_ENST00000409332.1_Missense_Mutation_p.P134S|UBE2F-SCLY_ENST00000449191.1_Missense_Mutation_p.P102S|UBE2F_ENST00000409953.1_Missense_Mutation_p.P132S	NM_001278305.1|NM_080678.2	NP_001265234.1|NP_542409.1	Q969M7	UBE2F_HUMAN	ubiquitin-conjugating enzyme E2F (putative)	156					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding			endometrium(1)|large_intestine(1)	2		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;6.7e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|Kidney(56;3.53e-09)|KIRC - Kidney renal clear cell carcinoma(57;9.79e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000136)|Lung(119;0.0126)|LUSC - Lung squamous cell carcinoma(224;0.0301)		TTTTGATGATCCACTGAATAT	0.373000													15	44					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10788459	10788459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10788459G>A	ENST00000283025.2	-	1	343	c.272C>T	c.(271-273)cCc>cTc	p.P91L		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	91					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						CCAGTCGTGGGGGCTATAGCG	0.672000													16	68					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45795022	45795022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45795022C>T	ENST00000357450.4	-	6	1065	c.1066G>A	c.(1066-1068)Gaa>Aaa	p.E356K	SMC1B_ENST00000404354.3_Missense_Mutation_p.E356K	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	356					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		AAAATTTCTTCCTCAATCTGC	0.378000													23	192					0	0	1	0	0
CERS1	10715	broad.mit.edu	37	19	19004363	19004363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19004363G>A	ENST00000427170.2	-	2	342	c.271C>T	c.(271-273)Ctc>Ttc	p.L91F	GDF1_ENST00000247005.6_5'UTR|CERS1_ENST00000542296.2_5'UTR|CERS1_ENST00000429504.2_Missense_Mutation_p.L91F	NM_001492.4|NM_021267.3	NP_001483.3|NP_067090.1	P27544	CERS1_HUMAN	ceramide synthase 1	91					ceramide biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|microsome	sphingosine N-acyltransferase activity			endometrium(3)|lung(2)	5						CTGGGCTGGAGGCAGCACCGC	0.632000													5	10					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53907760	53907760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:53907760C>T	ENST00000396328.1	-	15	2882	c.2643G>A	c.(2641-2643)caG>caA	p.Q881Q	WDR72_ENST00000559418.1_Silent_p.Q891Q|WDR72_ENST00000360509.5_Silent_p.Q881Q|WDR72_ENST00000557913.1_Silent_p.Q878Q	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	881										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		GAATTCCAACCTGATTTGGAA	0.318000													22	67					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27456001	27456001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27456001C>T	ENST00000264705.4	+	19	3146	c.2984C>T	c.(2983-2985)tCt>tTt	p.S995F	CAD_ENST00000403525.1_Missense_Mutation_p.S932F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	995	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GATGAGATCTCTTTTGAGGTG	0.488000													16	34					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71003108	71003108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71003108C>T	ENST00000334414.6	-	4	764	c.720G>A	c.(718-720)gcG>gcA	p.A240A	PTPRB_ENST00000550857.1_Silent_p.A22A|PTPRB_ENST00000451516.2_Silent_p.A22A|PTPRB_ENST00000551525.1_Silent_p.A239A|PTPRB_ENST00000550358.1_Silent_p.A240A|PTPRB_ENST00000538708.1_Silent_p.A22A|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000261266.5_Silent_p.A22A	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	22	Fibronectin type-III 3.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCTCTGGCTCCGCCAGTCCAG	0.522000													5	56					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16745363	16745363	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:16745363C>T	ENST00000381323.3	-	5	413		c.e5-1		FAM49A_ENST00000406434.1_Splice_Site|FAM49A_ENST00000355549.2_Splice_Site	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A							intracellular		p.?(1)		breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TTTGAATTGCCTGCAAAAACA	0.373000													10	39					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162740180	162740180	+	Missense_Mutation	SNP	C	C	T	rs140710321	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:162740180C>T	ENST00000367922.2	+	13	1820	c.1382C>T	c.(1381-1383)tCa>tTa	p.S461L	DDR2_ENST00000367921.3_Missense_Mutation_p.S461L	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	461					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CGCTCCTCATCACCTAGTGAA	0.498000													55	117					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234891	21234891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21234891C>T	ENST00000233242.1	-	26	4976	c.4849G>A	c.(4849-4851)Gga>Aga	p.G1617R		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1617					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTAGTGATCCAGAAAGCAGG	0.423000													20	49					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324106	79324106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79324106C>T	ENST00000428286.1	-	8	3207	c.2007G>A	c.(2005-2007)ggG>ggA	p.G669G	PRUNE2_ENST00000376718.3_Silent_p.G1028G			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1028					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TGTCTAGGTTCCCAGGACCTG	0.448000													12	21					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74401596	74401596	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74401596G>A	ENST00000319380.7	-	2	540	c.477_splice	c.e2+1	p.T159_splice		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	159							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						AGGACTCACGGTGGATCGCAT	0.602000													4	10					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30915444	30915444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30915444C>T	ENST00000375712.3	+	7	2115	c.1948C>T	c.(1948-1950)Cgt>Tgt	p.R650C	KIF3B_ENST00000418717.2_Missense_Mutation_p.R276C	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	650	Globular.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CATGATGATTCGTCCAGAGGC	0.478000													21	76					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21840062	21840062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21840062G>A	ENST00000216297.2	-	3	639	c.301C>T	c.(301-303)Cct>Tct	p.P101S		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	101					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		GTGATGGCAGGGGCTCCATTA	0.383000													16	60					0	0	1	0	0
CHKB	1120	broad.mit.edu	37	22	51018247	51018247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:51018247G>A	ENST00000406938.2	-	9	1157	c.940C>T	c.(940-942)Cgt>Tgt	p.R314C	CHKB-CPT1B_ENST00000452668.1_5'UTR	NM_005198.4	NP_005189.2	Q9Y259	CHKB_HUMAN	choline kinase beta	314					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|ovary(3)|skin(1)|urinary_tract(1)	15		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	AGGTAATGACGAATAAAATGC	0.488000													58	119					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44800029	44800029	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44800029C>T	ENST00000309315.4	+	9	1200	c.1077C>T	c.(1075-1077)acC>acT	p.T359T	ZMIZ2_ENST00000441627.1_Silent_p.T359T|ZMIZ2_ENST00000433667.1_Silent_p.T327T|ZMIZ2_ENST00000413916.1_Silent_p.T301T|ZMIZ2_ENST00000265346.7_Silent_p.T333T	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	359	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TACAGCCTACCCGTTCCATCC	0.587000													7	73					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12837370	12837370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12837370C>T	ENST00000357726.4	+	3	1107	c.1080C>T	c.(1078-1080)atC>atT	p.I360I		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	360										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTGTGGGATCGTGGATTCCC	0.617000													50	138					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6926366	6926366	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6926366G>A	ENST00000011653.4	+	7	1284	c.1026G>A	c.(1024-1026)ttG>ttA	p.L342L		NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	342	Ig-like C2-type 3.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				TGCTGAGTTTGAAACTGGAGA	0.567000													7	21					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128491627	128491627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128491627C>T	ENST00000325888.8	+	35	6048	c.5787C>T	c.(5785-5787)atC>atT	p.I1929I	FLNC_ENST00000346177.6_Silent_p.I1896I|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1929					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ACAGCATCATCGTGCGCTTCG	0.587000													30	76					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56490890	56490890	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56490890G>A	ENST00000291971.3	+	9	3078	c.3007G>A	c.(3007-3009)Gag>Aag	p.E1003K	NLRP8_ENST00000590542.1_Missense_Mutation_p.E984K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	1003						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GACCTTGTGCGAGGCCTTCTC	0.478000													42	106					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420762	55420762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55420762C>T	ENST00000242994.3	+	2	917	c.539C>T	c.(538-540)tCt>tTt	p.S180F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	180					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						GGCCCTCAGTCTGTCCTCCTG	0.537000													26	68					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41160355	41160355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41160355G>A	ENST00000263413.3	-	11	1837	c.1573C>T	c.(1573-1575)Cca>Tca	p.P525S	C6_ENST00000337836.5_Missense_Mutation_p.P525S|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	525	EGF-like.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTAGGGCATGGAGCACACTGG	0.507000													45	126					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11596488	11596488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11596488C>T	ENST00000304391.6	+	5	701	c.583C>T	c.(583-585)Ctt>Ttt	p.L195F	PTCHD2_ENST00000389575.3_Silent_p.F1308F|PTCHD2_ENST00000294484.6_Silent_p.F1308F			Q9P2K9	PTHD2_HUMAN	patched domain containing 2	0					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TGCCCCTCTTCTTCTGCATCA	0.642000													23	65					0	0	1	0	0
ZMYND10	51364	broad.mit.edu	37	3	50380626	50380626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50380626C>T	ENST00000231749.3	-	6	1794	c.522G>A	c.(520-522)aaG>aaA	p.K174K	ZMYND10-AS1_ENST00000440013.1_RNA|ZMYND10_ENST00000360165.3_Silent_p.K174K	NM_015896.2	NP_056980.2	O75800	ZMY10_HUMAN	zinc finger, MYND-type containing 10	174						cytoplasm	protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|urinary_tract(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCTCTGCCTGCTTCTGCAGCT	0.577000										TSP Lung(30;0.18)			19	39					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69049851	69049851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69049851C>T	ENST00000295381.3	+	10	1996	c.1577C>T	c.(1576-1578)tCc>tTc	p.S526F	ARHGAP25_ENST00000409202.3_Missense_Mutation_p.S527F|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.S520F|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.S487F|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.S220F|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.S519F	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	526					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						GCCTGTGACTCCAAGGGAGAT	0.527000													61	110					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84683354	84683354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84683354C>T	ENST00000286744.5	+	24	4258	c.4034C>T	c.(4033-4035)tCc>tTc	p.S1345F	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.S1345F	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1345	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGCAATGTTTCCTTGCTTTTC	0.428000													53	176					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7618780	7618780	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7618780C>T	ENST00000221249.6	+	22	2597	c.2166C>T	c.(2164-2166)ccC>ccT	p.P722P	PNPLA6_ENST00000450331.3_Silent_p.P722P|PNPLA6_ENST00000414982.3_Silent_p.P770P|PNPLA6_ENST00000545201.2_Silent_p.P695P|PNPLA6_ENST00000600737.1_Silent_p.P760P	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	761					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						TGGGTGTGCCCCCACACTCGG	0.582000													14	54					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73047412	73047412	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73047412G>A	ENST00000604411.1	+	0	35373				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AGAAACAGCAGAAAGGAGGCC	0.438000													4	6					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23897778	23897778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23897778C>T	ENST00000355349.3	-	15	1671	c.1509G>A	c.(1507-1509)aaG>aaA	p.K503K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	503	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CGATGCCCTCCTTCTTGTACT	0.512000													33	112					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77377921	77377921	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77377921C>T	ENST00000451710.3	-	26	3903	c.3666G>A	c.(3664-3666)ctG>ctA	p.L1222L	TRPM6_ENST00000376864.4_Silent_p.L1222L|TRPM6_ENST00000449912.2_Silent_p.L1217L|TRPM6_ENST00000360774.1_Silent_p.L1222L|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Silent_p.L1217L|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1222					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AAAGGACTTTCAGGGTATCCA	0.473000													24	80					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48438674	48438674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48438674C>T	ENST00000224605.2	-	1	302	c.37G>A	c.(37-39)Ggg>Agg	p.G13R		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	13					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						agcTGGGGCCCGGGTCCCGGG	0.726000													5	25					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30963132	30963132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30963132C>T	ENST00000311813.4	+	4	753	c.698C>T	c.(697-699)cCa>cTa	p.P233L	AQP1_ENST00000509504.1_Missense_Mutation_p.P410L|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Missense_Mutation_p.P182L|AQP1_ENST00000409899.1_Missense_Mutation_p.P118L|AQP1_ENST00000441328.2_Missense_Mutation_p.P150L|AQP1_ENST00000434909.2_Missense_Mutation_p.P293L	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				ATCCTGGCCCCACGCAGCAGT	0.597000													19	28					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5227059	5227059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5227059C>T	ENST00000334314.3	-	1	85	c.9G>A	c.(7-9)acG>acA	p.T3T	AKR1CL1_ENST00000445191.1_Intron					aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						GCTTCAGATCCGTCATCATCC	0.507000													20	43					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66478830	66478830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:66478830C>T	ENST00000256447.4	-	3	1998	c.1841G>A	c.(1840-1842)aGg>aAg	p.R614K		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	614	LRRCT.				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		CTTAACTCCCCTTAGAGATGG	0.413000													37	79					0	0	1	0	0
MOXD1	26002	broad.mit.edu	37	6	132693826	132693826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:132693826G>A	ENST00000367963.3	-	4	702	c.584C>T	c.(583-585)cCc>cTc	p.P195L	MOXD1_ENST00000336749.3_Missense_Mutation_p.P127L	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	195					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		GTTTGGGATGGGGACCTGTCT	0.373000													30	40					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28478849	28478849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28478849G>A	ENST00000261609.7	-	28	4420	c.4312C>T	c.(4312-4314)Cgc>Tgc	p.R1438C		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1438					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AACAACAAGCGACCGACCTCT	0.463000													29	67					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541199	55541199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55541199C>T	ENST00000220676.1	+	4	4905	c.4757C>T	c.(4756-4758)cCa>cTa	p.P1586L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1586					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATCAAAAGTCCAGTGACTTCT	0.403000													42	55					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121353122	121353122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121353122G>A	ENST00000314583.3	-	10	926	c.835C>T	c.(835-837)Cca>Tca	p.P279S	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.P242S	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	279					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		ACTGGCTGTGGAGCCTCAGGG	0.597000													23	64					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52595973	52595973	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52595973C>T	ENST00000395489.2	-	8	840	c.444G>A	c.(442-444)gaG>gaA	p.E148E	A1CF_ENST00000373993.1_Silent_p.E155E|A1CF_ENST00000282641.2_Silent_p.E155E|A1CF_ENST00000373997.3_Silent_p.E155E|A1CF_ENST00000374001.1_Silent_p.E155E|A1CF_ENST00000395495.1_Silent_p.E155E|A1CF_ENST00000373995.3_Silent_p.E163E	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	155	RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CCTTTTTCATCTCCGATAAGA	0.468000													29	131					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62675455	62675455	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62675455G>A	ENST00000498273.1	+	4	1304	c.1008_splice	c.e4-1	p.D337_splice		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	337										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						TAACTTTCAGGATAAAACCCT	0.294000													19	79					0	0	1	0	0
IGHA1	3493	broad.mit.edu	37	14	106173691	106173691	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106173691G>A	ENST00000390547.2	-	0	875																											TGGTCACAGCGAAGGTGGTGG	0.662000													17	81					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140985474	140985474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140985474C>T	ENST00000544766.1	+	5	1563	c.1036C>T	c.(1036-1038)Ccc>Tcc	p.P346S	MAGEC3_ENST00000409007.1_Missense_Mutation_p.P346S|MAGEC3_ENST00000298296.1_Silent_p.I596I|MAGEC3_ENST00000536088.1_Missense_Mutation_p.P346S|MAGEC3_ENST00000443323.2_Missense_Mutation_p.P266S	NM_177456.2	NP_803251.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	0	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGTATCATCCCTAGTGCCT	0.473000													64	41					0	0	1	0	0
MRPL4	51073	broad.mit.edu	37	19	10368915	10368915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10368915C>T	ENST00000393733.2	+	6	490	c.463C>T	c.(463-465)Ccc>Tcc	p.P155S	MRPL4_ENST00000253099.6_Missense_Mutation_p.P155S|MRPL4_ENST00000307422.5_Missense_Mutation_p.P155S|MRPL4_ENST00000588502.1_Missense_Mutation_p.P154S|CTD-2369P2.5_ENST00000592893.1_RNA|MRPL4_ENST00000590669.1_Missense_Mutation_p.P155S			Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4	155					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		TGCCCATGGCCCCCGGGGCCC	0.637000													5	39					0	0	1	0	0
CLEC2B	9976	broad.mit.edu	37	12	10010183	10010183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10010183G>A	ENST00000228438.2	-	3	1060	c.127C>T	c.(127-129)Caa>Taa	p.Q43*		NM_005127.2	NP_005118.2	Q92478	CLC2B_HUMAN	C-type lectin domain family 2, member B	43	C-type lectin.					integral to plasma membrane	sugar binding			endometrium(1)|large_intestine(3)|lung(1)	5						CATTTGTTTTGGAAACCAATC	0.318000													9	34					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370219	126370219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126370219C>T	ENST00000394329.3	+	9	8061	c.8048C>T	c.(8047-8049)tCc>tTc	p.S2683F	FAT4_ENST00000335110.5_Missense_Mutation_p.S981F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2683	Cadherin 26.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAAAACCTTTCCCCTCGAAAA	0.353000													73	174					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416045	178416045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178416045G>A	ENST00000231188.5	-	6	1423	c.1245C>T	c.(1243-1245)ctC>ctT	p.L415L	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Silent_p.L415L	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	415					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GCATGCTGTGGAGGGCGTGGG	0.632000													12	22					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141607771	141607771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141607771G>A	ENST00000389484.3	-	29	5810	c.4839C>T	c.(4837-4839)ttC>ttT	p.F1613F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1613					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGATGCATCGAAGTCTATCA	0.373000										TSP Lung(27;0.18)			31	79					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9027420	9027420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9027420C>T	ENST00000383836.3	-	22	3510	c.3083G>A	c.(3082-3084)aGc>aAc	p.S1028N	SRGAP3_ENST00000360413.3_Missense_Mutation_p.S1004N	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	1028					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GGAGCTGCTGCTGCGGCGCAT	0.726000			T	RAF1	pilocytic astrocytoma								28	41					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20668326	20668326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20668326G>A	ENST00000404938.2	+	4	776	c.124G>A	c.(124-126)Gga>Aga	p.G42R		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	695	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						CTTTGCTGATGGACTGGACAT	0.463000													7	36					0	0	1	0	0
FAM214B	80256	broad.mit.edu	37	9	35108046	35108046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35108046G>A	ENST00000378561.1	-	2	3281	c.226C>T	c.(226-228)Ccc>Tcc	p.P76S	FAM214B_ENST00000378554.2_Missense_Mutation_p.P76S|FAM214B_ENST00000378557.1_Missense_Mutation_p.P76S|FAM214B_ENST00000322813.5_Missense_Mutation_p.P76S|FAM214B_ENST00000605244.1_Missense_Mutation_p.P76S|FAM214B_ENST00000378566.1_Intron|FAM214B_ENST00000603301.1_Missense_Mutation_p.P76S|FAM214B_ENST00000488109.2_Missense_Mutation_p.P76S			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	76						nucleus											AGCTCCCGGGGACCCTCAGTG	0.637000													11	32					0	0	1	0	0
TMEM74	157753	broad.mit.edu	37	8	109797140	109797140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:109797140G>A	ENST00000297459.3	-	2	366	c.188C>T	c.(187-189)tCt>tTt	p.S63F	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	63					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			GGATGCTGGAGAAGAACTAAG	0.517000													12	131					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121328208	121328208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121328208C>T	ENST00000297848.3	+	40	4901	c.4631C>T	c.(4630-4632)cCa>cTa	p.P1544L	COL14A1_ENST00000247781.3_Missense_Mutation_p.P1449L|COL14A1_ENST00000309791.4_Missense_Mutation_p.P1544L	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1544	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GTTGGTTCACCAGGACGTGAT	0.502000													14	37					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71490409	71490409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71490409C>T	ENST00000296755.7	+	5	1525	c.1227C>T	c.(1225-1227)gtC>gtT	p.V409V		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	409						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTGATCCTGTCATTCTTTTCC	0.403000													26	104					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724491	138724491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:138724491G>A	ENST00000383163.2	-	1	619	c.620C>T	c.(619-621)tCa>tTa	p.S207L		NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	207	Pro-rich.									endometrium(3)|kidney(1)|lung(7)	11						GTGTCCCTCTGAACTGGGGTT	0.652000													5	14					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75276414	75276414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75276414C>T	ENST00000325680.7	+	7	4977	c.4853C>T	c.(4852-4854)cCc>cTc	p.P1618L	YLPM1_ENST00000552421.1_Missense_Mutation_p.P912L|YLPM1_ENST00000238571.3_Missense_Mutation_p.P1423L	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		TCTTCCATTCCCCCTCCTGGC	0.483000													11	55					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147108974	147108974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:147108974C>T	ENST00000383075.3	-	4	1260	c.748G>A	c.(748-750)Gac>Aac	p.D250N	ZIC4_ENST00000484399.1_Missense_Mutation_p.D250N|ZIC4_ENST00000473123.1_Missense_Mutation_p.D250N|ZIC4_ENST00000525172.2_Missense_Mutation_p.D300N|ZIC4_ENST00000472749.2_5'UTR|ZIC4_ENST00000425731.3_Missense_Mutation_p.D288N|ZIC4_ENST00000491672.1_Missense_Mutation_p.D44N	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	250						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TTCTTACGGTCGCTGCTGTTG	0.612000													8	32					0	0	1	0	0
DHRS2	10202	broad.mit.edu	37	14	24108541	24108541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24108541G>A	ENST00000250383.6	+	3	770	c.294G>A	c.(292-294)gaG>gaA	p.E98E	DHRS2_ENST00000344777.7_Silent_p.E98E|DHRS2_ENST00000553896.1_3'UTR	NM_005794.3	NP_005785.1	Q13268	DHRS2_HUMAN	dehydrogenase/reductase (SDR family) member 2	76					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00659)		GGAAGGCTGAGGACCGGGAGC	0.652000													11	37					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815131	106815131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106815131G>A	ENST00000407775.2	+	8	3071	c.2821G>A	c.(2821-2823)Ggc>Agc	p.G941S	ZFPM2_ENST00000520492.1_Missense_Mutation_p.G809S|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.G672S|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.G809S|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	941					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AACCCTGCAAGGCTTGAAGGT	0.408000													10	28					0	0	1	0	0
AHCY	191	broad.mit.edu	37	20	32879235	32879235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32879235G>A	ENST00000538132.1	-	5	850	c.464C>T	c.(463-465)tCc>tTc	p.S155F	AHCY_ENST00000217426.2_Missense_Mutation_p.S183F	NM_001161766.1	NP_001155238.1	P23526	SAHH_HUMAN	adenosylhomocysteinase	183					methylation|xenobiotic metabolic process	cytosol|melanosome	adenosylhomocysteinase activity|protein binding			endometrium(6)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CTTGGTGACGGAGTCATTGAC	0.572000													44	96					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116067573	116067573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116067573C>T	ENST00000369271.3	-	10	1363	c.1063G>A	c.(1063-1065)Gag>Aag	p.E355K	AFAP1L2_ENST00000545353.1_Missense_Mutation_p.E408K|AFAP1L2_ENST00000304129.4_Missense_Mutation_p.E355K	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	355	PH 2.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		CTGGATGTCTCGAGGGACCTC	0.542000													15	54					0	0	1	0	0
MIOX	55586	broad.mit.edu	37	22	50927994	50927994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50927994C>T	ENST00000395732.3	+	9	692	c.670C>T	c.(670-672)Ccc>Tcc	p.P224S	MIOX_ENST00000395733.3_Intron|MIOX_ENST00000216075.6_Missense_Mutation_p.P224S			Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	224					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	13		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTCCTTCTACCCCTGGCACAC	0.677000													16	29					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961754	34961754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34961754C>T	ENST00000329357.5	+	1	842	c.806C>T	c.(805-807)tCc>tTc	p.S269F		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	269	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						ACTCTGGTGTCCAGTGTCCAC	0.627000													47	38					0	0	1	0	0
KLRC1	3821	broad.mit.edu	37	12	10603085	10603085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10603085G>A	ENST00000544822.1	-	4	668	c.281C>T	c.(280-282)cCc>cTc	p.P94L	KLRC1_ENST00000536188.1_Missense_Mutation_p.P94L|KLRC1_ENST00000408006.3_Missense_Mutation_p.P94L|KLRC1_ENST00000359151.3_Missense_Mutation_p.P94L|KLRC1_ENST00000347831.5_Missense_Mutation_p.P94L	NM_213658.2	NP_998823.1	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C, member 1	94					cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16						AGACTTACAGGGAATAACAAC	0.383000													25	100					0	0	1	0	0
PDCD7	10081	broad.mit.edu	37	15	65411101	65411101	+	Missense_Mutation	SNP	G	G	A	rs61756022	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65411101G>A	ENST00000204549.4	-	5	1466	c.1412C>T	c.(1411-1413)cCg>cTg	p.P471L		NM_005707.1	NP_005698.1	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	471					apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex				endometrium(4)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	7						GCTGGGGAGCGGGGGAAGGAC	0.498000													23	81					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1943501	1943501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1943501C>T	ENST00000543818.1	+	5	1569	c.727C>T	c.(727-729)Ccc>Tcc	p.P243S	LRTM2_ENST00000543730.1_3'UTR|LRTM2_ENST00000535041.1_Missense_Mutation_p.P243S|LRTM2_ENST00000299194.1_Missense_Mutation_p.P243S|CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000382722.5_Intron|CACNA2D4_ENST00000585732.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	243	LRRCT.					integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GCGGATGGTCCCCATGGAGAT	0.602000													13	44					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14711407	14711407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14711407C>T	ENST00000284268.6	-	12	1708	c.1378G>A	c.(1378-1380)Gag>Aag	p.E460K	ANKH_ENST00000535119.1_Missense_Mutation_p.E262K	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	460					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						GACTCATTCTCCATCTTCTTT	0.532000													10	163					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11535948	11535948	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11535948T>A	ENST00000262442.3	+	8	1631	c.1563T>A	c.(1561-1563)gaT>gaA	p.D521E	DNAH9_ENST00000454412.2_Missense_Mutation_p.D521E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	521	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AAGTAGAAGATCTTGACCGAA	0.408000													36	76					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121786416	121786416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121786416G>A	ENST00000261367.7	+	12	3443	c.2015G>A	c.(2014-2016)gGa>gAa	p.G672E	CTC-210G5.1_ENST00000510972.1_RNA|SNCAIP_ENST00000414317.2_Missense_Mutation_p.G227E|SNCAIP_ENST00000379538.3_Missense_Mutation_p.G259E|SNCAIP_ENST00000379533.2_Missense_Mutation_p.G672E|CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000503116.2_3'UTR|CTC-210G5.1_ENST00000506053.1_RNA|CTC-210G5.1_ENST00000505546.1_RNA|CTC-210G5.1_ENST00000503529.1_RNA|SNCAIP_ENST00000261368.8_Missense_Mutation_p.G625E|SNCAIP_ENST00000379536.2_Missense_Mutation_p.G565E|SNCAIP_ENST00000542191.1_Missense_Mutation_p.G183E|SNCAIP_ENST00000504884.2_3'UTR			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	625					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CAGTTATTGGGAAAGGAAATC	0.458000													23	59					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37251039	37251039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37251039C>T	ENST00000310758.4	-	13	1685	c.1038G>A	c.(1036-1038)gaG>gaA	p.E346E	ELMO1_ENST00000448602.1_Silent_p.E346E|ELMO1_ENST00000442504.1_Silent_p.E346E	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	346	ELMO.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						ACTTGCGTTTCTCCATGCTGC	0.488000													21	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179505290	179505290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179505290C>T	ENST00000589042.1	-	221	40925	c.40701G>A	c.(40699-40701)agG>agA	p.R13567R	TTN-AS1_ENST00000418062.1_RNA|TTN_ENST00000342992.6_Silent_p.R10999R|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Silent_p.R4502R|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.R4694R|TTN_ENST00000359218.5_Silent_p.R4627R|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.R11926R|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11926	Ig-like 92.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGGAATCTTCCTTTCCCTTT	0.323000													26	126					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4327185	4327185	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4327185G>A	ENST00000600324.1	-	8	766	c.699C>T	c.(697-699)ttC>ttT	p.F233F	STAP2_ENST00000597593.1_5'UTR|STAP2_ENST00000594605.1_Silent_p.F233F	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	233	SH2.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TATGCGACACGAAATAGTTGA	0.617000													8	56					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799175	45799175	+	Silent	SNP	G	G	A	rs146049499		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45799175G>A	ENST00000553795.1	-	4	1004	c.696C>T	c.(694-696)acC>acT	p.T232T	OR13A1_ENST00000374401.2_Silent_p.T232T|OR13A1_ENST00000536058.1_Silent_p.T232T	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						AGGACGCGATGGTCATCAGGA	0.572000													26	82					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69329484	69329484	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:69329484C>T	ENST00000260364.5	+	9	1552	c.1251C>T	c.(1249-1251)gcC>gcT	p.A417A	NOX5_ENST00000455873.3_Silent_p.A400A|NOX5_ENST00000448182.3_Silent_p.A389A|NOX5_ENST00000530406.2_Silent_p.A407A|NOX5_ENST00000388866.3_Silent_p.A435A			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	435	Ferric oxidoreductase.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						TGGAGAAGGCCATCGGACTGG	0.567000													35	97					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4348328	4348328	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4348328C>T	ENST00000355530.2	+	3	547	c.265_splice	c.e3-1	p.V89_splice	SPNS3_ENST00000576069.1_Intron|SPNS3_ENST00000333476.2_Intron	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	89					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						CTCCTTCAGTCTTCGTTAGCT	0.612000													67	160					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128365332	128365332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128365332G>A	ENST00000262462.4	+	9	2625	c.1615G>A	c.(1615-1617)Gaa>Aaa	p.E539K	SLC27A6_ENST00000395266.1_Missense_Mutation_p.E539K|SLC27A6_ENST00000506176.1_Missense_Mutation_p.E539K			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	539					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TTTAGATTTGGAAAAAGTTTA	0.303000													22	43					0	0	1	0	0
RANBP10	57610	broad.mit.edu	37	16	67763634	67763634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67763634G>A	ENST00000317506.3	-	9	1211	c.1096C>T	c.(1096-1098)Ccc>Tcc	p.P366S	RANBP10_ENST00000536251.1_Missense_Mutation_p.P137S|RANBP10_ENST00000448631.2_Missense_Mutation_p.P310S|RANBP10_ENST00000411657.2_Missense_Mutation_p.P249S|RANBP10_ENST00000602677.1_Missense_Mutation_p.P366S	NM_020850.1	NP_065901.1	Q6VN20	RBP10_HUMAN	RAN binding protein 10	366	Ser-rich.									endometrium(5)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		CTGAGGCTGGGGGAGCCAGGG	0.607000													22	71					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143412128	143412128	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:143412128C>T	ENST00000316549.6	-	5	763	c.555G>A	c.(553-555)gtG>gtA	p.V185V		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	185					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						TCATAGCCTTCACAAAACCAT	0.378000													28	81					0	0	1	0	0
ADRBK2	157	broad.mit.edu	37	22	26118352	26118352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26118352C>T	ENST00000324198.5	+	21	2194	c.2002C>T	c.(2002-2004)Cct>Tct	p.P668S		NM_005160.3	NP_005151.2	P35626	ARBK2_HUMAN	adrenergic, beta, receptor kinase 2	668							ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|skin(3)|stomach(2)	32					Adenosine triphosphate(DB00171)	CCTCAACAAACCTCGGTCAGG	0.552000													29	70					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884549	228884549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228884549G>A	ENST00000392056.3	-	7	1067	c.1021C>T	c.(1021-1023)Cca>Tca	p.P341S	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P341S	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	341						cytoplasm	protein binding	p.P341T(2)|p.P341K(2)		NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCATCTTTTGGAATATACAGT	0.423000													58	130					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88780987	88780987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88780987C>T	ENST00000418177.2	-	2	421	c.54G>A	c.(52-54)ggG>ggA	p.G18G	GRM5_ENST00000305447.4_Silent_p.G18G|GRM5_ENST00000393297.1_Silent_p.G18G|GRM5_ENST00000393294.3_Silent_p.G18G|GRM5_ENST00000455756.2_Silent_p.G18G|GRM5_ENST00000305432.5_Silent_p.G18G			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	18					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ACTGTGCACTCCCACGGACAT	0.468000													31	70					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368848	86368848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:86368848C>T	ENST00000400286.2	-	2	2394	c.1796G>A	c.(1795-1797)cGa>cAa	p.R599Q		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	599						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CGTAAGAGATCGTAAAATAGT	0.418000													38	119					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8752443	8752443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8752443G>A	ENST00000534127.1	-	6	779	c.394C>T	c.(394-396)Ctc>Ttc	p.L132F	ST5_ENST00000530438.1_Intron|ST5_ENST00000526757.1_Intron|ST5_ENST00000357665.1_Missense_Mutation_p.L132F|ST5_ENST00000313726.6_Missense_Mutation_p.L132F	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	132					positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		GCAAGGGGGAGGCAGGCAGCG	0.667000													16	75					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152737732	152737732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152737732G>A	ENST00000367255.5	-	41	6441	c.5840C>T	c.(5839-5841)tCc>tTc	p.S1947F	SYNE1_ENST00000341594.5_Missense_Mutation_p.S1984F|SYNE1_ENST00000423061.1_Missense_Mutation_p.S1954F|SYNE1_ENST00000448038.1_Missense_Mutation_p.S1954F|SYNE1_ENST00000265368.4_Missense_Mutation_p.S1947F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1947					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGCTCTGCAGGAAGTCCTTTG	0.502000										HNSCC(10;0.0054)			37	67					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80045076	80045076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80045076G>A	ENST00000306749.2	-	21	3495	c.3277C>T	c.(3277-3279)Cac>Tac	p.H1093Y		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1093					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CCGGAGATGTGGACGCCTCCG	0.667000													4	17					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9084665	9084665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9084665C>T	ENST00000397910.4	-	1	7353	c.7150G>A	c.(7150-7152)Gat>Aat	p.D2384N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2384	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTAGTGACATCCATAGTTGAA	0.473000													16	27					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110399131	110399131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110399131G>A	ENST00000360185.4	-	11	1103	c.939C>T	c.(937-939)gtC>gtT	p.V313V	GIT2_ENST00000343646.5_Silent_p.V313V|GIT2_ENST00000551209.1_Silent_p.V312V|GIT2_ENST00000356259.4_Silent_p.V313V|GIT2_ENST00000457474.2_Silent_p.V315V|TCHP_ENST00000550780.1_Intron|GIT2_ENST00000354574.4_Silent_p.V315V|GIT2_ENST00000553118.1_Silent_p.V313V|GIT2_ENST00000355312.3_Silent_p.V313V|GIT2_ENST00000338373.5_Silent_p.V313V|GIT2_ENST00000320063.9_Silent_p.V313V|GIT2_ENST00000547815.1_Silent_p.V313V|GIT2_ENST00000361006.5_Silent_p.V313V			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	313					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						GAAAGGGGACGACCGTTGTCT	0.517000													23	43					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588254	93588254	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93588254G>A	ENST00000329082.7	-	4	1598	c.1327C>T	c.(1327-1329)Ctg>Ttg	p.L443L	RGMA_ENST00000543599.1_Silent_p.L427L|RGMA_ENST00000557420.1_3'UTR|RGMA_ENST00000538818.1_Silent_p.L334L|RGMA_ENST00000425933.2_Silent_p.L427L|RGMA_ENST00000556658.1_Silent_p.L334L|RGMA_ENST00000557301.1_Silent_p.L451L|RGMA_ENST00000542321.2_Silent_p.L427L	NM_020211.2	NP_064596.2	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	443					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			AGCAGGGCCAGGAGCGGGACG	0.716000													13	14					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774191	40774191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:40774191G>A	ENST00000602553.1	-	5	1378	c.1084C>T	c.(1084-1086)Ctc>Ttc	p.L362F	ZNF658_ENST00000441795.1_Missense_Mutation_p.L360F|ZNF658_ENST00000377626.3_Missense_Mutation_p.L362F			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTCTGGTAGAGGGCATCTGTA	0.363000													89	195					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134991144	134991144	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:134991144C>T	ENST00000535938.1	+	13	1730	c.1563C>T	c.(1561-1563)tcC>tcT	p.S521S	SAGE1_ENST00000370709.3_Silent_p.S521S|SAGE1_ENST00000537770.1_Intron|SAGE1_ENST00000324447.3_Silent_p.S521S	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	521										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					GTATTCCATCCATGAGTACCA	0.403000													39	23					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76412312	76412312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76412312G>A	ENST00000357063.3	+	21	4847	c.3587G>A	c.(3586-3588)cGa>cAa	p.R1196Q	LMO7_ENST00000341547.4_Missense_Mutation_p.R862Q|LMO7_ENST00000377534.3_Missense_Mutation_p.R1196Q|LMO7_ENST00000321797.8_Missense_Mutation_p.R911Q|LMO7_ENST00000465261.2_Missense_Mutation_p.R911Q|LMO7_ENST00000526202.1_Missense_Mutation_p.R788Q			Q8WWI1	LMO7_HUMAN	LIM domain 7	1196						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TTAAAAAGGCGATCACAATTT	0.338000													9	40					0	0	1	0	0
WNT10B	7480	broad.mit.edu	37	12	49359997	49359997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49359997G>A	ENST00000301061.4	-	5	1399	c.1051C>T	c.(1051-1053)Cgt>Tgt	p.R351C	WNT10B_ENST00000403957.1_3'UTR|WNT10B_ENST00000407467.1_3'UTR	NM_003394.3	NP_003385.2	O00744	WN10B_HUMAN	wingless-type MMTV integration site family, member 10B	351					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|large_intestine(5)|lung(12)|prostate(1)|skin(4)	23						TTGTGCCCACGGCCACAGCAC	0.627000													5	59					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108819293	108819293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108819293G>A	ENST00000232603.5	-	5	367	c.285C>T	c.(283-285)ttC>ttT	p.F95F	MORC1_ENST00000483760.1_Silent_p.F95F	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	95					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						ATTGCCCTATGAACTTCAAGG	0.363000													54	134					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52822170	52822170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52822170C>T	ENST00000252245.5	-	7	1472	c.1252G>A	c.(1252-1254)Gag>Aag	p.E418K	RP11-1020M18.10_ENST00000548135.1_RNA	NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	418	Coil 2.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		TGCAGGGCCTCCTCAAGGTCC	0.597000													8	41					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324972	152324972	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152324972G>A	ENST00000388718.5	-	3	5362	c.5290C>T	c.(5290-5292)Cat>Tat	p.H1764Y	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1764							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTCTCATGAACTATGGAT	0.507000													93	254					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237037099	237037099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237037099C>T	ENST00000366577.5	+	23	2826	c.2432C>T	c.(2431-2433)cCa>cTa	p.P811L	MTR_ENST00000535889.1_Missense_Mutation_p.P760L	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	811	B12-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GTCATGACTCCATGTGATAAG	0.378000													27	84					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52472065	52472065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52472065G>A	ENST00000231721.2	-	14	1659	c.1660C>T	c.(1660-1662)Ctt>Ttt	p.L554F		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	554					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CGCTTGCCAAGGCTGGGGCGG	0.672000													9	32					0	0	1	0	0
RIOK3	8780	broad.mit.edu	37	18	21053552	21053552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21053552C>T	ENST00000339486.3	+	8	1592	c.975C>T	c.(973-975)atC>atT	p.I325I	RIOK3_ENST00000577501.1_Silent_p.I325I|RIOK3_ENST00000581585.1_Silent_p.I309I	NM_003831.3	NP_003822.2	O14730	RIOK3_HUMAN	RIO kinase 3	325	Protein kinase.			I -> H (in Ref. 1; AAC26080).	chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(2)	10	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GTAAGATCATCCGCATGTGGG	0.323000													7	50					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11000810	11000810	+	Silent	SNP	C	C	T	rs141202424	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11000810C>T	ENST00000324288.8	+	11	1594	c.1461C>T	c.(1459-1461)atC>atT	p.I487I	CIITA_ENST00000381835.5_Intron|CIITA_ENST00000537380.1_Intron	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	487	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						TCAGCCACATCTTGAAGAGAC	0.622000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								51	110					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37334448	37334448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37334448C>T	ENST00000262825.5	+	14	2833	c.2616C>T	c.(2614-2616)ccC>ccT	p.P872P	CSF2RB_ENST00000536485.1_Silent_p.P813P|CSF2RB_ENST00000406230.1_Silent_p.P872P|CSF2RB_ENST00000403662.3_Silent_p.P866P	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	866					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	AGGCTGTGCCCCAGGTGCCCG	0.592000													40	163					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	72431580	72431580	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:72431580C>T	ENST00000553530.1	+	2	279	c.72C>T	c.(70-72)atC>atT	p.I24I	RGS6_ENST00000343854.6_Silent_p.I24I|RGS6_ENST00000553525.1_Silent_p.I24I|RGS6_ENST00000404301.2_Silent_p.I24I|RGS6_ENST00000406236.4_Silent_p.I24I|RGS6_ENST00000556437.1_Silent_p.I24I|RGS6_ENST00000407322.4_Silent_p.I24I|RGS6_ENST00000355512.6_Silent_p.I24I|RGS6_ENST00000555571.1_Silent_p.I24I|RGS6_ENST00000402788.2_Silent_p.I24I	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	24					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAAACATGATCGTTTACTGCA	0.502000													23	64					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117663617	117663617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117663617G>A	ENST00000368508.3	-	28	4813	c.4615C>T	c.(4615-4617)Cct>Tct	p.P1539S	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.P1533S	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1539	Fibronectin type-III 6.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGTTCCAAAGGATCTGAATAA	0.333000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								6	49					0	0	1	0	0
SMTN	6525	broad.mit.edu	37	22	31489689	31489689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31489689C>T	ENST00000404574.1	+	1	346	c.256C>T	c.(256-258)Cca>Tca	p.P86S	SMTN_ENST00000347557.2_Intron|SMTN_ENST00000333137.7_Intron|SMTN_ENST00000358743.1_Intron			P53814	SMTN_HUMAN	smoothelin	209					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						GCTGGGGGTCCCACTTGTGTC	0.697000													4	11					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5708755	5708755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5708755C>T	ENST00000356134.5	-	22	2202	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	ANO2_ENST00000327087.8_Missense_Mutation_p.E710K|ANO2_ENST00000546188.1_Missense_Mutation_p.E711K	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	715						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TCTCCAGCTTCGGTCTCATCT	0.453000													34	78					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71707097	71707097	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71707097G>A	ENST00000356340.3	+	36	2560	c.2025_splice	c.e36+1	p.R675_splice	COL13A1_ENST00000398968.3_Splice_Site_p.R656_splice|COL13A1_ENST00000520133.1_Splice_Site_p.R597_splice|COL13A1_ENST00000398966.3_Splice_Site_p.R653_splice|COL13A1_ENST00000398969.3_Splice_Site_p.R603_splice|COL13A1_ENST00000398974.3_Splice_Site_p.R663_splice|COL13A1_ENST00000398972.3_Splice_Site_p.R661_splice|COL13A1_ENST00000398973.3_Splice_Site_p.R649_splice|COL13A1_ENST00000398971.3_Splice_Site_p.R660_splice|COL13A1_ENST00000520267.1_Splice_Site_p.R603_splice|COL13A1_ENST00000398964.3_Splice_Site_p.R646_splice|COL13A1_ENST00000357811.3_Splice_Site_p.R641_splice|COL13A1_ENST00000354547.3_Splice_Site_p.R653_splice|COL13A1_ENST00000517713.1_Splice_Site_p.R626_splice|COL13A1_ENST00000522165.1_Splice_Site_p.R644_splice|COL13A1_ENST00000398978.3_Splice_Site_p.R675_splice			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	675	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AAGGGAAACCGGGTGAGTCTG	0.512000													10	44					0	0	1	0	0
NOMO1	23420	broad.mit.edu	37	16	14989431	14989431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:14989431G>A	ENST00000287667.7	+	31	3769	c.3598G>A	c.(3598-3600)Gca>Aca	p.A1200T		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	1200						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						GCTCGGCCAGGCAGCCTCTGA	0.537000													64	627					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70461399	70461399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:70461399C>T	ENST00000327305.6	-	6	1249	c.592G>A	c.(592-594)Gag>Aag	p.E198K	NETO1_ENST00000583169.1_Missense_Mutation_p.E198K|NETO1_ENST00000299430.2_Missense_Mutation_p.E197K	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	198	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TCAACAGCCTCGCTAGCAGTA	0.458000													18	143					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4835910	4835910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4835910G>A	ENST00000252318.2	+	2	761	c.424G>A	c.(424-426)Gac>Aac	p.D142N	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	142						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						GGCGGCCCAGGACCTCTTCCG	0.552000													21	49					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74276190	74276190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74276190G>A	ENST00000262765.5	-	12	4353	c.4174C>T	c.(4174-4176)Cgg>Tgg	p.R1392W		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1392							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						GATTTCCACCGATCCTCCAGC	0.672000													25	76					0	0	1	0	0
CRY1	1407	broad.mit.edu	37	12	107395596	107395596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107395596G>A	ENST00000008527.5	-	4	1408	c.541C>T	c.(541-543)Cct>Tct	p.P181S		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	181					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						TCAGACAGAGGAGTTGTGCAC	0.398000													45	139					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438833	179438833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179438833C>T	ENST00000589042.1	-	326	72250	c.72026G>A	c.(72025-72027)aGt>aAt	p.S24009N	TTN_ENST00000342992.6_Missense_Mutation_p.S21441N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S14944N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S15136N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S15069N|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S22368N|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22368	Fibronectin type-III 74.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATGGTGGACTGATGGCACC	0.418000													31	61					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36759570	36759570	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36759570C>T	ENST00000416516.2	-	4	2174	c.1684G>A	c.(1684-1686)Gag>Aag	p.E562K		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	562	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TTAAAGAGCTCGTCCTGGTCC	0.552000													32	225					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20658726	20658726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20658726C>T	ENST00000525748.1	+	12	2019	c.1746C>T	c.(1744-1746)acC>acT	p.T582T	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	582				T -> S (in Ref. 2; AAD27892).	synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	AGTTTGCCACCATCGAGACCA	0.493000													33	125					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57118354	57118354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57118354C>T	ENST00000263314.2	+	8	858	c.824C>T	c.(823-825)tCc>tTc	p.S275F		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	275					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity	p.S275Y(1)		endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						AGCAGCGTGTCCCCAGGCTAC	0.552000													17	74					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50850753	50850753	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:50850753C>T	ENST00000404971.1	-	7	2271	c.931_splice	c.e7-1	p.G311_splice	NRXN1_ENST00000402717.3_Splice_Site_p.R278_splice|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401669.2_Splice_Site_p.G278_splice|NRXN1_ENST00000406859.3_Splice_Site_p.R278_splice|NRXN1_ENST00000405472.3_Splice_Site_p.G278_splice|NRXN1_ENST00000406316.2_Splice_Site_p.G278_splice	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	278	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TTCTTCTTTTCCTAGAGGAAA	0.363000													12	21					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473712	19473712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:19473712C>T	ENST00000507958.1	-	15	2986	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K	CDH18_ENST00000382275.1_Missense_Mutation_p.E666K|CDH18_ENST00000274170.4_Missense_Mutation_p.E666K|CDH18_ENST00000502796.1_3'UTR|CDH18_ENST00000510297.1_5'UTR|CDH18_ENST00000506372.1_3'UTR			Q13634	CAD18_HUMAN	cadherin 18, type 2	666					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TCTGTGTCTTCCTCTCCGCCT	0.507000													51	145					0	0	1	0	0
RPL10L	140801	broad.mit.edu	37	14	47120402	47120402	+	Missense_Mutation	SNP	C	C	T	rs61745038	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:47120402C>T	ENST00000298283.3	-	1	626	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	180					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome	p.E180K(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						TCTTCAAATTCGTCAGCATTA	0.517000													50	99					0	0	1	0	0
KLRG1	10219	broad.mit.edu	37	12	9144893	9144893	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9144893G>A	ENST00000266551.4	+	2	189	c.174G>A	c.(172-174)tgG>tgA	p.W58*	KLRG1_ENST00000356986.3_Nonsense_Mutation_p.W58*|RP11-259O18.4_ENST00000545706.1_RNA|KLRG1_ENST00000538029.1_Intron	NM_005810.3	NP_005801.3	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G, member 1	58			W -> R (in dbSNP:rs1805749).		cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			breast(1)|central_nervous_system(1)|kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8						TATACCAGTGGATCCTGTGCC	0.388000													78	170					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126732423	126732423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:126732423C>T	ENST00000274473.6	+	7	879	c.612C>T	c.(610-612)gaC>gaT	p.D204D	MEGF10_ENST00000418761.2_Silent_p.D204D|MEGF10_ENST00000503335.2_Silent_p.D204D|MEGF10_ENST00000508365.1_Silent_p.D204D	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	204	EGF-like 3.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CCACCTGCGACCACGTCACGG	0.637000													18	78					0	0	1	0	0
BMX	660	broad.mit.edu	37	X	15549483	15549483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:15549483G>A	ENST00000357607.2	+	11	1160	c.972G>A	c.(970-972)tcG>tcA	p.S324S	BMX_ENST00000348343.6_Silent_p.S324S|BMX_ENST00000342014.6_Silent_p.S324S			P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	324	SH2.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(14)|ovary(2)|urinary_tract(3)	30	Hepatocellular(33;0.183)					TTAGAAATTCGAGCCAAGTGG	0.323000													33	57					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30316198	30316198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:30316198G>A	ENST00000361371.4	-	23	4161	c.4011C>T	c.(4009-4011)tcC>tcT	p.S1337S	LTN1_ENST00000389194.2_Silent_p.S1383S	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	1337							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						CATTCTGAAAGGATGTTTCAG	0.358000													43	112					0	0	1	0	0
BAP1	8314	broad.mit.edu	37	3	52441424	52441424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52441424C>T	ENST00000460680.1	-	6	899	c.428G>A	c.(427-429)aGc>aAc	p.S143N	BAP1_ENST00000296288.5_Missense_Mutation_p.S143N	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	143					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CCTGGCATGGCTATTATGGGC	0.537000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							31	91					0	0	1	0	0
IGHV5-51	28388	broad.mit.edu	37	14	107034953	107034953	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107034953C>T	ENST00000390626.2	-	0	185																											TATCCAGAACCCTTACAGGAG	0.567000													10	30					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431164	56431164	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56431164G>A	ENST00000302969.2	+	1	27	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						TTGAAGCAATGGATAAAGAAA	0.398000													40	151					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124351444	124351444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124351444G>A	ENST00000360013.3	+	35	5481	c.5354G>A	c.(5353-5355)gGa>gAa	p.G1785E	KALRN_ENST00000428018.2_Missense_Mutation_p.G88E|KALRN_ENST00000291478.4_Missense_Mutation_p.G88E|KALRN_ENST00000393496.1_Missense_Mutation_p.G158E	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1785					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AAGGCAGATGGAAACATCAAA	0.552000													47	82					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310132	57310132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57310132G>A	ENST00000457912.1	+	2	71	c.71G>A	c.(70-72)gGg>gAg	p.G24E	SMTNL1_ENST00000527972.1_Missense_Mutation_p.G6E|SMTNL1_ENST00000399154.2_Missense_Mutation_p.G6E			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	6										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						CAGAAGGAAGGGAAGCTCTCT	0.602000													6	26					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860953	16860953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16860953C>T	ENST00000524140.2	+	6	1918	c.1500C>T	c.(1498-1500)ggC>ggT	p.G500G	NWD1_ENST00000523826.1_Silent_p.G294G|NWD1_ENST00000379808.3_Silent_p.G500G|NWD1_ENST00000339803.6_Silent_p.G365G|NWD1_ENST00000552788.1_Silent_p.G500G|NWD1_ENST00000549814.1_Silent_p.G500G	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	500	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAAACCAAGGCCAGCAGATGA	0.637000													9	83					0	0	1	0	0
SPAG4	6676	broad.mit.edu	37	20	34206880	34206880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34206880G>A	ENST00000374273.3	+	8	865	c.753G>A	c.(751-753)gaG>gaA	p.E251E		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	251					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity			NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GGCTGAATGAGGATTTTGTGC	0.592000													18	50					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634394	156634394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156634394G>A	ENST00000296518.7	+	7	1440	c.1231G>A	c.(1231-1233)Gat>Aat	p.D411N	GUCY1A3_ENST00000511108.1_Missense_Mutation_p.D411N|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.D411N|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.D411N|GUCY1A3_ENST00000393832.3_Missense_Mutation_p.D153N|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.D411N|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.D411N			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	411					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity	p.R410>?(1)		central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TGCACTGAGGGATGTGGTCTT	0.517000													23	56					0	0	1	0	0
BSND	7809	broad.mit.edu	37	1	55473947	55473947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55473947G>A	ENST00000371265.4	+	4	863	c.609G>A	c.(607-609)atG>atA	p.M203I		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	203						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						ACCTGGACATGGACTCCAGTG	0.617000													16	39					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28992873	28992873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28992873C>T	ENST00000359747.4	+	15	2524	c.2495C>T	c.(2494-2496)tCt>tTt	p.S832F	DSG4_ENST00000308128.4_Missense_Mutation_p.S813F|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	813					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGAGTCGGGTCTCCCGTAGGC	0.428000													30	87					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992412	85992412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85992412C>T	ENST00000372105.3	-	4	1164	c.1143G>A	c.(1141-1143)agG>agA	p.R381R		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	381						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GGGGGACATGCCTGGCCACCA	0.607000													8	25					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1551584	1551584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1551584C>T	ENST00000381605.4	-	4	1015	c.951G>A	c.(949-951)gtG>gtA	p.V317V	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000262929.5_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	317	Ig-like C1-type 2.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CACAGGTGTTCACCAGGAGCC	0.552000													17	135					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578277	7578277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7578277G>A	ENST00000420246.2	-	6	704	c.572C>T	c.(571-573)cCt>cTt	p.P191L	TP53_ENST00000574684.1_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.P191L|TP53_ENST00000455263.2_Missense_Mutation_p.P191L|TP53_ENST00000413465.2_Missense_Mutation_p.P191L|TP53_ENST00000269305.4_Missense_Mutation_p.P191L|TP53_ENST00000359597.4_Missense_Mutation_p.P191L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	191	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> H (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.P191del(7)|p.?(6)|p.P191delP(4)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.P191L(2)|p.P191R(2)|p.G187fs*16(2)|p.P59delP(2)|p.P98delP(2)|p.P191fs*56(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P191H(1)|p.P191_Q192delPQ(1)|p.D186_P191delDGLAPP(1)|p.P98_E105>Q(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.L188_P191del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AAGATGCTGAGGAGGGGCCAG	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	22					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98413354	98413354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98413354G>A	ENST00000186436.5	-	27	3194	c.2966C>T	c.(2965-2967)tCc>tTc	p.S989F		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	989						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						AAAGCGTAAGGAGCTTCCTGG	0.423000													23	56					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110819517	110819517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110819517G>A	ENST00000375820.4	-	44	4058	c.3937C>T	c.(3937-3939)Cca>Tca	p.P1313S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1313	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TGAAATCCTGGAACTCCTGGA	0.527000													54	160					0	0	1	0	0
GLIPR1	11010	broad.mit.edu	37	12	75874745	75874745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:75874745G>A	ENST00000266659.3	+	1	286	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K		NM_006851.2	NP_006842.2	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1	29					cellular lipid metabolic process	extracellular region|integral to membrane		p.E29K(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	14						GCCAGATATCGAAAATGAAGA	0.403000													14	76					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647813	51647813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51647813C>T	ENST00000317643.6	+	2	653	c.584C>T	c.(583-585)tCc>tTc	p.S195F	SIGLEC7_ENST00000305628.7_Intron|SIGLEC7_ENST00000600577.1_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	195	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CTGCACCCCTCCACCACCCGC	0.667000													54	107					0	0	1	0	0
WDR45B	56270	broad.mit.edu	37	17	80579641	80579641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80579641G>A	ENST00000392325.4	-	6	656	c.462C>T	c.(460-462)tcC>tcT	p.S154S	WDR45B_ENST00000571835.1_5'UTR	NM_019613.3	NP_062559.2			WD repeat domain 45B																		AGGCCAGGAGGGAGTTGTTAC	0.572000													11	33					0	0	1	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12836064	12836064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12836064C>T	ENST00000357726.4	+	2	693	c.666C>T	c.(664-666)ttC>ttT	p.F222F		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	222										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTATAAGGTTCGCCCCTTACC	0.527000													62	126					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004453	41004453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41004453C>T	ENST00000399564.4	-	37	4639	c.4189G>A	c.(4189-4191)Gaa>Aaa	p.E1397K	MROH2B_ENST00000506092.2_Missense_Mutation_p.E952K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CTTACATCTTCAAAGAAGGTC	0.458000													50	96					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450355	158450355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158450355C>T	ENST00000368152.1	+	1	688	c.688C>T	c.(688-690)Ccc>Tcc	p.P230S	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					ACTTGTGGTTCCCTTTCTGTT	0.438000													35	140					0	0	1	0	0
OR3A4P	390756	broad.mit.edu	37	17	3213706	3213706	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3213706C>T	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							TTGTCATCTTCCTTCTTGCTT	0.527000													24	39					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27703020	27703020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27703020G>A	ENST00000438700.3	-	1	277	c.160C>T	c.(160-162)Ccc>Tcc	p.P54S		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	54					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GAGGGTTCGGGGGATTTCGGG	0.697000													35	82					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172834990	172834990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172834990C>T	ENST00000351008.3	-	2	715	c.532G>A	c.(532-534)Gta>Ata	p.V178I		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	178					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TTTAAGGCTACCTGAAGCCAT	0.438000													19	162					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82835440	82835440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82835440C>T	ENST00000265077.3	+	8	7183	c.6618C>T	c.(6616-6618)ttC>ttT	p.F2206F	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.F1219F|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2206	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CACATTTTTTCTTAGCTACTG	0.373000													35	98					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131750420	131750420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131750420C>T	ENST00000372577.2	+	24	2509	c.2488C>T	c.(2488-2490)Cct>Tct	p.P830S		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	830					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						GCTGAAACCTCCTTCTAATGT	0.498000													54	188					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248789634	248789634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248789634C>T	ENST00000330803.2	-	1	857	c.796G>A	c.(796-798)Gag>Aag	p.E266K		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGTCCTGCTCGGGGGTGTGG	0.502000													22	74					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179718276	179718276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179718276C>T	ENST00000420890.2	-	20	3253	c.3136G>A	c.(3136-3138)Gaa>Aaa	p.E1046K	CCDC141_ENST00000295723.5_Missense_Mutation_p.E471K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	471							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTCACAGCTTCCTTTGTCTTG	0.423000													33	80					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52604519	52604519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52604519C>T	ENST00000521776.2	+	2	2312	c.1579C>T	c.(1579-1581)Ccc>Tcc	p.P527S		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	527					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TAAGGAGCTTCCCAGACCTGT	0.468000													71	138					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879171	3879171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3879171C>T	ENST00000315677.3	-	4	1493	c.898G>A	c.(898-900)Gac>Aac	p.D300N	DLGAP1_ENST00000584874.1_Missense_Mutation_p.D300N|DLGAP1_ENST00000581527.1_Missense_Mutation_p.D300N|DLGAP1_ENST00000515196.2_Missense_Mutation_p.D300N|DLGAP1-AS3_ENST00000577649.1_RNA	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	300					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				ATGGCCTGGTCCATGTTCACC	0.592000													15	54					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139907193	139907193	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139907193G>A	ENST00000265662.5	-	31	5199	c.5052C>T	c.(5050-5052)ctC>ctT	p.L1684L	ABCA2_ENST00000371605.3_Silent_p.L1683L|ABCA2_ENST00000341511.6_Silent_p.L1684L			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1683					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGGAGGTGAAGAGCAGGTACT	0.672000													14	49					0	0	1	0	0
SYN3	8224	broad.mit.edu	37	22	32914070	32914070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32914070C>T	ENST00000358763.2	-	13	1812	c.1570G>A	c.(1570-1572)Gaa>Aaa	p.E524K	SYN3_ENST00000332840.5_Missense_Mutation_p.E524K|SYN3_ENST00000467095.1_5'UTR	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	524	J; Pro-rich linker.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						TTGGACTCTTCACCCTGCTGG	0.602000													32	71					0	0	1	0	0
MIR363	574031	broad.mit.edu	37	X	133303440	133303440	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:133303440C>T	ENST00000384840.1	-	0	42					NR_029852.1																						AATTTTTCTCCTATGATACTC	0.388000													23	31					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176762775	176762775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176762775G>A	ENST00000367662.3	+	20	6264	c.5100G>A	c.(5098-5100)ctG>ctA	p.L1700L		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1700	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CTGACACTCTGGAGCACTGGA	0.473000													24	66					0	0	1	0	0
OGFR	11054	broad.mit.edu	37	20	61444719	61444719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61444719C>T	ENST00000370461.1	+	5	3873	c.1596C>T	c.(1594-1596)ccC>ccT	p.P532P	OGFR_ENST00000290291.6_Silent_p.P584P|OGFR_ENST00000370468.3_Intron			Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	584	7 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]- [GR]-D-E-P-A-[EK].				regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity			endometrium(2)|kidney(1)|lung(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	17	Breast(26;3.65e-08)					CCCCAGGCCCCAGCCCGGCAG	0.746000													4	26					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62288742	62288742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62288742G>A	ENST00000378024.4	-	5	13421	c.13147C>T	c.(13147-13149)Ccc>Tcc	p.P4383S	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4383					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GAGATTTTGGGGGCCTTGATG	0.483000													89	231					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735176	55735176	+	Missense_Mutation	SNP	G	G	A	rs142455941		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55735176G>A	ENST00000312345.2	-	1	814	c.764C>T	c.(763-765)cCa>cTa	p.P255L		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P255Q(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AAACTGATGTGGTTTGGGCTG	0.393000													20	43					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54578016	54578016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54578016C>T	ENST00000336470.4	+	11	1018	c.879C>T	c.(877-879)gtC>gtT	p.V293V	GNL3L_ENST00000360845.2_Silent_p.V293V	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	293	G.				ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						TGCAGGAGGTCTACCTGGACA	0.587000													6	23					0	0	1	0	0
SELPLG	6404	broad.mit.edu	37	12	109017754	109017754	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109017754C>T	ENST00000388962.3	-	2	489	c.330G>A	c.(328-330)ggG>ggA	p.G110G	SELPLG_ENST00000550948.1_Silent_p.G110G|SELPLG_ENST00000228463.6_Silent_p.G126G	NM_003006.4	NP_002997.2	Q14242	SELPL_HUMAN	selectin P ligand	110					blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(3)|skin(1)	12						TGGACAGGTTCCCCATGTTGG	0.607000													27	50					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97604280	97604280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97604280G>A	ENST00000371203.5	+	4	634	c.47G>A	c.(46-48)aGg>aAg	p.R16K	ENTPD1_ENST00000490659.1_3'UTR|ENTPD1_ENST00000543964.1_Missense_Mutation_p.R46K|ENTPD1_ENST00000539125.1_Missense_Mutation_p.R16K|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000371207.3_Missense_Mutation_p.R166K|ENTPD1_ENST00000453258.2_Missense_Mutation_p.R161K|ENTPD1_ENST00000371205.4_Missense_Mutation_p.R154K|RP11-429G19.3_ENST00000433113.1_RNA	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	154					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		GTGGTGGAGAGGAGCCTCAGC	0.458000													15	188					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	84025043	84025043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:84025043C>T	ENST00000369705.3	-	6	806	c.690G>A	c.(688-690)gaG>gaA	p.E230E	ME1_ENST00000543031.1_Silent_p.E155E|ME1_ENST00000541327.1_Silent_p.E64E	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	230					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AAGAAACTGCCTCCATGAATT	0.308000													34	67					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35803197	35803197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35803197C>T	ENST00000361922.4	+	11	1880	c.1730C>T	c.(1729-1731)tCt>tTt	p.S577F	MAG_ENST00000392213.3_Intron|MAG_ENST00000537831.2_Intron	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	0					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			AAAGAGGTTTCTACCCTGGAA	0.627000													49	107					0	0	1	0	0
B3GALT1	8708	broad.mit.edu	37	2	168725844	168725844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168725844G>A	ENST00000305861.1	+	2	646	c.295G>A	c.(295-297)Gag>Aag	p.E99K	AC016723.4_ENST00000436982.2_RNA|B3GALT1_ENST00000392690.2_Missense_Mutation_p.E99K|AC016723.4_ENST00000430546.1_RNA	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	99					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						GGCAATCAGAGAGACGTGGGG	0.463000													24	79					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67354558	67354558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67354558G>A	ENST00000304372.5	-	2	289	c.234C>T	c.(232-234)tcC>tcT	p.S78S	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	78						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CTGCACAACTGGAGAAGGAGA	0.478000													9	101					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6190872	6190872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6190872G>A	ENST00000530810.1	-	1	766	c.685C>T	c.(685-687)Cgt>Tgt	p.R229C	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGGCAAACGAAACACTGCT	0.478000													17	35					0	0	1	0	0
PIGV	55650	broad.mit.edu	37	1	27124182	27124182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27124182C>T	ENST00000374145.1	+	4	2011	c.1329C>T	c.(1327-1329)tcC>tcT	p.S443S	PIGV_ENST00000449950.2_Silent_p.S215S|PIGV_ENST00000078527.4_Silent_p.S443S	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	443					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CAGAGGACTCCCCACCAGGAC	0.478000													12	65					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40669560	40669560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40669560C>T	ENST00000454349.2	+	7	3308	c.3097C>T	c.(3097-3099)Cac>Tac	p.H1033Y	TNRC6B_ENST00000402203.1_Missense_Mutation_p.H286Y|TNRC6B_ENST00000301923.9_Missense_Mutation_p.H286Y|TNRC6B_ENST00000335727.8_Missense_Mutation_p.H980Y	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1033					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						TGCTTCCTCCCACAACTCAGC	0.552000													4	4					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113075045	113075045	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113075045C>T	ENST00000316851.7	+	2	135	c.135C>T	c.(133-135)ttC>ttT	p.F45F	NCAM1_ENST00000401611.2_Silent_p.F54F|NCAM1_ENST00000533760.1_5'UTR|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	55	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TCTCCTGGTTCTCCCCCAATG	0.468000													8	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179457165	179457165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179457165G>A	ENST00000589042.1	-	301	59791	c.59567C>T	c.(59566-59568)tCt>tTt	p.S19856F	TTN_ENST00000342992.6_Missense_Mutation_p.S17288F|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S10791F|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S10983F|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S10916F|TTN_ENST00000591111.1_Missense_Mutation_p.S18215F|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18215	Ig-like 110.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGTTAAAGAATAAATTCC	0.358000													47	207					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33093395	33093395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33093395G>A	ENST00000307363.5	-	8	1038	c.894C>T	c.(892-894)gcC>gcT	p.A298A	GLB1_ENST00000399402.3_Silent_p.A268A|GLB1_ENST00000307377.8_Silent_p.A167A|GLB1_ENST00000445488.2_Silent_p.A346A	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	298					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				TCGCCCCACGGGCAAGTATAT	0.512000													21	65					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48258241	48258241	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48258241G>A	ENST00000394747.1	-	4	844	c.495C>T	c.(493-495)ttC>ttT	p.F165F	ABCC11_ENST00000537808.1_Silent_p.F165F|ABCC11_ENST00000353782.5_Silent_p.F165F|ABCC11_ENST00000394748.1_Silent_p.F165F|ABCC11_ENST00000356608.2_Silent_p.F165F	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	165	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GAAGTGCATCGAAAATCAACC	0.512000													25	53					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158259858	158259858	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158259858C>T	ENST00000368170.3	+	1	283	c.4C>T	c.(4-6)Ctg>Ttg	p.L2L		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	2					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					AAATGACATGCTGTTTCTGCA	0.438000													27	79					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101715232	101715232	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101715232G>A	ENST00000342239.3	-	4	2090	c.1999C>T	c.(1999-2001)Cgt>Tgt	p.R667C	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Missense_Mutation_p.R667C			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	667					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CAGGTAGGACGGTGTCGAGAT	0.597000													11	31					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53610870	53610870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:53610870G>A	ENST00000342160.3	-	41	5625	c.5168C>T	c.(5167-5169)cCt>cTt	p.P1723L	HUWE1_ENST00000262854.6_Missense_Mutation_p.P1723L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1723					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TAGGGCCAAAGGGGTATCTAT	0.438000													53	33					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67101751	67101751	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67101751G>A	ENST00000284425.2	-	20	2766	c.2592C>T	c.(2590-2592)atC>atT	p.I864I		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	864					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					GGAATATTGCGATTCCAAATA	0.274000													9	48					0	0	1	0	0
MAPK8IP2	23542	broad.mit.edu	37	22	51041867	51041867	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:51041867C>T	ENST00000329492.3	+	3	504	c.387C>T	c.(385-387)tcC>tcT	p.S129S	MAPK8IP2_ENST00000341339.4_Intron|MAPK8IP2_ENST00000442429.2_Silent_p.S129S|MAPK8IP2_ENST00000399912.1_5'UTR|MAPK8IP2_ENST00000399908.2_5'UTR|MAPK8IP2_ENST00000008876.5_Silent_p.S102S	NM_012324.3	NP_036456.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	129	JNK-binding domain (JBD).				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTCCCCTTCCGTGGAGGAGC	0.697000													6	9					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215848384	215848384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215848384C>T	ENST00000272895.7	-	29	4588	c.4369G>A	c.(4369-4371)Gag>Aag	p.E1457K	ABCA12_ENST00000389661.4_Missense_Mutation_p.E1139K	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1457	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTTACTTCCTCGTGGAGCTGC	0.433000													16	77					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	344285	344285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:344285G>A	ENST00000343164.4	-	7	854	c.802C>T	c.(802-804)Cca>Tca	p.P268S	SLC6A13_ENST00000445055.2_Missense_Mutation_p.P176S	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	268					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GTGAGGTTTGGGTACAGGTAA	0.557000													15	67					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48762861	48762861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48762861C>T	ENST00000316623.5	-	36	4884	c.4429G>A	c.(4429-4431)Gaa>Aaa	p.E1477K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1477	EGF-like 25; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CTGTCCAGTTCGTAGCCTATC	0.567000													28	60					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33152024	33152024	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33152024G>A	ENST00000341947.2	-	8	1244	c.1017C>T	c.(1015-1017)ccC>ccT	p.P339P	COL11A2_ENST00000357486.1_Silent_p.P318P|COL11A2_ENST00000361917.1_Intron|COL11A2_ENST00000374708.4_Intron|COL11A2_ENST00000395197.1_Intron|COL11A2_ENST00000374712.1_Intron|COL11A2_ENST00000374713.1_Silent_p.P292P|COL11A2_ENST00000374714.1_Silent_p.P313P	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	339	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GCCCTTCAGGGGGGTCTGTGC	0.612000													37	92					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12939479	12939479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12939479G>A	ENST00000393233.2	-	5	782	c.233C>T	c.(232-234)gCc>gTc	p.A78V	RTBDN_ENST00000589272.1_Silent_p.C151C|RTBDN_ENST00000592204.1_Silent_p.C129C|RTBDN_ENST00000458671.2_Silent_p.C119C|RTBDN_ENST00000322912.5_Silent_p.C151C|CTD-2265O21.3_ENST00000588469.1_RNA	NM_001270440.1	NP_001257369.1	Q9BSG5	RTBDN_HUMAN	retbindin	0						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						ACCAGGCCTGGCAGAGCTCCT	0.652000													9	35					0	0	1	0	0
IGLC7	28834	broad.mit.edu	37	22	23264783	23264783	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23264783C>T	ENST00000390331.1	+	0	18																											CAAGGCTGCCCCCTCGGTCAC	0.622000													17	60					0	0	1	0	0
RASA2	5922	broad.mit.edu	37	3	141292000	141292000	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141292000C>T	ENST00000286364.3	+	13	1331	c.1296C>T	c.(1294-1296)tcC>tcT	p.S432S	RASA2_ENST00000452898.1_Silent_p.S432S			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	432	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						TATGTGACTCCTCAAAATCCT	0.229000													6	61					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206225329	206225329	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206225329T>A	ENST00000367126.4	+	1	1354	c.889T>A	c.(889-891)Ttc>Atc	p.F297I		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	297					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CTGGGCTCCCTTCTTCAGTGT	0.552000													31	69					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66191487	66191487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66191487C>T	ENST00000311034.2	+	7	1302	c.1126C>T	c.(1126-1128)Ccc>Tcc	p.P376S		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	376					transcription, DNA-dependent		DNA binding|signal transducer activity	p.F375_P376>S(1)		breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CACCAGCTTCCCCAGTGCTCC	0.552000													81	188					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84564785	84564785	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84564785G>A	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							ATGCCCCACAGGAAGCCTGTG	0.498000													4	7					0	0	1	0	0
ANAPC2	29882	broad.mit.edu	37	9	140079372	140079372	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140079372G>A	ENST00000323927.2	-	4	1045	c.1041C>T	c.(1039-1041)atC>atT	p.I347I		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	347					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CACCTCGGACGATGCTGAAGA	0.677000													3	26					0	0	1	0	0
GCAT	23464	broad.mit.edu	37	22	38211196	38211196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38211196C>T	ENST00000323205.6	+	5	781	c.718C>T	c.(718-720)Ctg>Ttg	p.L240L	GCAT_ENST00000248924.6_Silent_p.L214L	NM_001171690.1	NP_001165161.1	O75600	KBL_HUMAN	glycine C-acetyltransferase	214					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	12	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CATCGCACCCCTGCAGGAGAT	0.602000													4	42					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43986097	43986097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43986097C>T	ENST00000262726.7	-	24	3142	c.2889G>A	c.(2887-2889)atG>atA	p.M963I	EFCAB6_ENST00000396231.2_Missense_Mutation_p.M811I	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	963					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GATGGCGGTCCATAAGCTTAT	0.383000													32	82					0	0	1	0	0
PLCB3	5331	broad.mit.edu	37	11	64026164	64026164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64026164C>T	ENST00000540288.1	+	11	1335	c.1232C>T	c.(1231-1233)tCc>tTc	p.S411F	PLCB3_ENST00000279230.6_Missense_Mutation_p.S411F|PLCB3_ENST00000325234.5_Missense_Mutation_p.S344F	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	411	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						GTCATCCTCTCCTTCGAGAAC	0.612000													32	53					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115947782	115947782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115947782G>A	ENST00000251864.2	+	2	345	c.192G>A	c.(190-192)aaG>aaA	p.K64K	TDRD1_ENST00000369281.2_Silent_p.K64K|TDRD1_ENST00000369282.1_Silent_p.K64K|TDRD1_ENST00000369280.1_Silent_p.K64K|TDRD1_ENST00000422662.1_5'UTR	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	64					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GAAATAAAAAGAACAATTTTT	0.388000													44	116					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247607993	247607993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247607993C>T	ENST00000366497.2	+	8	3490	c.2710C>T	c.(2710-2712)Ctt>Ttt	p.L904F	NLRP3_ENST00000366496.2_Missense_Mutation_p.L904F|NLRP3_ENST00000336119.3_Missense_Mutation_p.L961F|NLRP3_ENST00000348069.2_Missense_Mutation_p.L847F|NLRP3_ENST00000391828.3_Missense_Mutation_p.L961F|NLRP3_ENST00000391827.2_Missense_Mutation_p.L904F	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	961					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTGCTGGGATCTTTCCACACT	0.527000													22	49					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316036	30316036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30316036G>A	ENST00000375377.1	-	3	3142	c.3041C>T	c.(3040-3042)cCa>cTa	p.P1014L		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	1014										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CGCTTCACTTGGTTTCACAGA	0.567000													58	119					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940609	144940609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144940609G>A	ENST00000525985.1	-	2	6884	c.6813C>T	c.(6811-6813)ttC>ttT	p.F2271F				P58107	EPIPL_HUMAN	epiplakin 1	2271						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTCGATGACGAAGCCGGTGG	0.716000													4	48					0	0	1	0	0
PCCB	5096	broad.mit.edu	37	3	135975435	135975435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:135975435C>T	ENST00000471595.1	+	3	360	c.342C>T	c.(340-342)atC>atT	p.I114I	PCCB_ENST00000466072.1_Silent_p.I114I|PCCB_ENST00000462637.1_Intron|PCCB_ENST00000251654.4_Silent_p.I114I|PCCB_ENST00000483687.1_Silent_p.I114I|PCCB_ENST00000469217.1_Silent_p.I114I|PCCB_ENST00000468777.1_Silent_p.I114I|PCCB_ENST00000482086.1_Intron|PCCB_ENST00000474833.1_Intron|PCCB_ENST00000478469.1_Silent_p.I114I|PCCB_ENST00000490504.1_Silent_p.I114I			P05166	PCCB_HUMAN	propionyl CoA carboxylase, beta polypeptide	114	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	25					Biotin(DB00121)|L-Valine(DB00161)	GAGGCCGAATCAATGGAAGAT	0.393000													5	86					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123256123	123256123	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123256123C>T	ENST00000358487.5	-	13	2058	c.1786G>A	c.(1786-1788)Gag>Aag	p.E596K	FGFR2_ENST00000356226.4_Missense_Mutation_p.E479K|FGFR2_ENST00000351936.6_Missense_Mutation_p.E594K|FGFR2_ENST00000369056.1_Missense_Mutation_p.E597K|FGFR2_ENST00000369061.4_Missense_Mutation_p.E484K|FGFR2_ENST00000346997.2_Missense_Mutation_p.E594K|FGFR2_ENST00000360144.3_Missense_Mutation_p.E508K|FGFR2_ENST00000369060.4_Missense_Mutation_p.E480K|FGFR2_ENST00000457416.2_Missense_Mutation_p.E597K|FGFR2_ENST00000357555.5_Missense_Mutation_p.E507K|FGFR2_ENST00000369059.1_Missense_Mutation_p.E482K|FGFR2_ENST00000478859.1_Missense_Mutation_p.E368K	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	596	Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GTCATCTGCTCCTCAGGAACA	0.517000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				90	223					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82416146	82416146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:82416146C>T	ENST00000370728.1	+	9	2117	c.1472C>T	c.(1471-1473)cCa>cTa	p.P491L	LPHN2_ENST00000359929.3_Missense_Mutation_p.P491L|LPHN2_ENST00000394879.1_Missense_Mutation_p.P491L|LPHN2_ENST00000370730.1_Missense_Mutation_p.P491L|LPHN2_ENST00000271029.4_Missense_Mutation_p.P491L|LPHN2_ENST00000370715.1_Missense_Mutation_p.P491L|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000335786.5_Missense_Mutation_p.P491L|LPHN2_ENST00000370725.1_Missense_Mutation_p.P491L|LPHN2_ENST00000370723.1_Missense_Mutation_p.P491L|LPHN2_ENST00000370721.1_Missense_Mutation_p.P429L|LPHN2_ENST00000370713.1_Missense_Mutation_p.P491L|LPHN2_ENST00000319517.6_Missense_Mutation_p.P491L|LPHN2_ENST00000370717.2_Missense_Mutation_p.P491L|LPHN2_ENST00000370727.1_Missense_Mutation_p.P491L			O95490	LPHN2_HUMAN	latrophilin 2	491					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GTTGAACGACCATGCCCTAAG	0.378000													22	67					0	0	1	0	0
GFI1	2672	broad.mit.edu	37	1	92946183	92946183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92946183G>A	ENST00000370332.1	-	4	1079	c.761C>T	c.(760-762)tCc>tTc	p.S254F	GFI1_ENST00000294702.5_Missense_Mutation_p.S254F|GFI1_ENST00000427103.1_Missense_Mutation_p.S254F	NM_001127215.1	NP_001120687.1	Q99684	GFI1_HUMAN	growth factor independent 1 transcription repressor	254					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		GCACTTGTAGGAGCCGCCGCC	0.716000													6	7					0	0	1	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423832	33423832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33423832G>A	ENST00000395064.2	+	2	1223	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	319	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						AGGGGACACTGAAGGGAATGG	0.547000													15	96					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103057133	103057133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103057133C>T	ENST00000375735.2	+	42	6940	c.6796C>T	c.(6796-6798)Cct>Tct	p.P2266S	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.P2266S	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2266	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CATTCAGACTCCTGACATGCA	0.428000													32	40					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73096514	73096514	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73096514C>T	ENST00000450736.2	+	4	1171	c.756C>T	c.(754-756)ttC>ttT	p.F252F	SLC16A5_ENST00000538213.2_Silent_p.F292F|SLC16A5_ENST00000329783.4_Silent_p.F252F|SLC16A5_ENST00000580123.1_Silent_p.F252F			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	252					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity	p.F252L(2)		central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	TCCTGGGCTTCCCACTGCCAC	0.607000													11	46					0	0	1	0	0
ZDHHC11	79844	broad.mit.edu	37	5	843767	843767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:843767G>A	ENST00000283441.8	-	4	959	c.576C>T	c.(574-576)ctC>ctT	p.L192L	ZDHHC11_ENST00000424784.2_Silent_p.L192L|ZDHHC11_ENST00000511539.1_5'UTR	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	192						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GGTACTGGACGAGGACATACA	0.647000													9	37					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53930378	53930378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53930378C>T	ENST00000371445.3	+	3	874	c.819C>T	c.(817-819)ccC>ccT	p.P273P		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	273	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						cactgccgccCCTTCCACCGC	0.677000													27	46					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120922487	120922487	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120922487G>A	ENST00000263713.5	+	22	2176		c.e22+1		EPB41L5_ENST00000488691.1_Splice_Site|EPB41L5_ENST00000443902.2_Splice_Site|EPB41L5_ENST00000452780.1_Splice_Site	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5							cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TGCACCTCAGGTAAATATGCT	0.328000													25	67					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62763514	62763514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62763514C>T	ENST00000336232.2	-	6	1007	c.872G>A	c.(871-873)aGg>aAg	p.R291K	SLC22A8_ENST00000535878.1_Missense_Mutation_p.R168K|SLC22A8_ENST00000545207.1_Missense_Mutation_p.R200K|SLC22A8_ENST00000430500.2_Missense_Mutation_p.R291K|SLC22A8_ENST00000311438.8_Missense_Mutation_p.R291K	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	291					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CAAGCTGAGCCTTTCTCCCTC	0.587000													10	127					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163250956	163250956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163250956C>T	ENST00000332142.5	-	12	2752	c.2653G>A	c.(2653-2655)Gga>Aga	p.G885R		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	885					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CAGTTGTCTCCTTCTGAATCA	0.333000													25	68					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31587038	31587038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31587038C>T	ENST00000379416.3	-	24	2665	c.2617G>A	c.(2617-2619)Gat>Aat	p.D873N		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	873					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGAGAGAGATCCTGGGTGTTC	0.572000													17	51					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226483628	226483628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226483628C>T	ENST00000328205.5	-	4	772	c.227G>A	c.(226-228)cGa>cAa	p.R76Q	LIN9_ENST00000481685.1_Intron|LIN9_ENST00000366801.1_Intron	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	60	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		AAGTCGACTTCGTTTTGAATT	0.348000													5	83					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943463	72943463	+	Missense_Mutation	SNP	G	G	A	rs113286281		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72943463G>A	ENST00000328801.4	+	6	1513	c.1513G>A	c.(1513-1515)Ggc>Agc	p.G505S		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	505						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					GCTGGGCCAGGGCCTGCAGCG	0.647000													17	42					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118469492	118469492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:118469492C>T	ENST00000311085.8	+	12	1953	c.1873C>T	c.(1873-1875)Ctc>Ttc	p.L625F	DMXL1_ENST00000539542.1_Missense_Mutation_p.L625F	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	625										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTCTACTGTTCTCAGTATTTC	0.378000													25	147					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140301677	140301677	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:140301677G>A	ENST00000275884.6	-	2	938	c.521C>T	c.(520-522)tCg>tTg	p.S174L	DENND2A_ENST00000537639.1_Missense_Mutation_p.S174L|DENND2A_ENST00000492720.1_Missense_Mutation_p.S174L|DENND2A_ENST00000496613.1_Missense_Mutation_p.S174L			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	174										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					CAGCCCTGCCGACCCATCCTT	0.597000													10	80					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46826217	46826217	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46826217G>A	ENST00000283296.7	-	17	3711	c.3423C>T	c.(3421-3423)gcC>gcT	p.A1141A	GPR116_ENST00000265417.7_Silent_p.A1141A|GPR116_ENST00000456426.2_Silent_p.A999A|GPR116_ENST00000362015.4_Silent_p.A1141A|GPR116_ENST00000545669.1_Silent_p.A570A	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1141					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			TGACCGAGATGGCAAGTGGGC	0.552000													9	40					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3673312	3673312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3673312G>A	ENST00000344754.4	-	15	3885	c.3886C>T	c.(3886-3888)Cac>Tac	p.H1296Y	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.H1296Y	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1296	Ig-like C2-type 13.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CGACCGTTGTGGTACCAAGTA	0.647000													14	36					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702720	30702720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30702720C>T	ENST00000256246.2	-	1	3888	c.3814G>A	c.(3814-3816)Gat>Aat	p.D1272N		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1272										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ACATTTGAATCTAAGACTGAT	0.343000													17	64					0	0	1	0	0
AMICA1	120425	broad.mit.edu	37	11	118071269	118071269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118071269G>A	ENST00000292067.7	-	6	1242	c.801C>T	c.(799-801)atC>atT	p.I267I	AMICA1_ENST00000356289.5_Silent_p.I277I|AMICA1_ENST00000533261.1_Silent_p.I266I|AMICA1_ENST00000526620.1_Silent_p.I238I	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	277					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TTCCCACAATGATCACCAACT	0.512000													29	63					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42028729	42028729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42028729C>T	ENST00000219905.7	+	13	4448	c.4267C>T	c.(4267-4269)Cct>Tct	p.P1423S	MGA_ENST00000389936.4_Missense_Mutation_p.P1423S|MGA_ENST00000570161.1_Missense_Mutation_p.P1423S|MGA_ENST00000545763.1_Missense_Mutation_p.P1423S|MGA_ENST00000566586.1_Missense_Mutation_p.P1423S	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1423						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TCCATTGTCCCCTGGGAAAAT	0.463000													16	33					0	0	1	0	0
ICOSLG	23308	broad.mit.edu	37	21	45656834	45656834	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45656834C>T	ENST00000407780.3	-	3	449	c.322G>A	c.(322-324)Gag>Aag	p.E108K	ICOSLG_ENST00000400379.3_Missense_Mutation_p.E108K|ICOSLG_ENST00000400377.3_Intron|ICOSLG_ENST00000344330.4_Missense_Mutation_p.E108K			O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand	108	Ig-like V-type.				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding			endometrium(2)|lung(1)|stomach(1)|urinary_tract(1)	5				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		AACTTCTGCTCGTCCTGGGGG	0.602000													7	98					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61568741	61568741	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61568741C>T	ENST00000577647.1	+	8	1234	c.1190_splice	c.e8+1	p.R397_splice	ACE_ENST00000413513.3_Splice_Site_p.R397_splice|ACE_ENST00000290866.4_Splice_Site_p.R971_splice|ACE_ENST00000428043.1_Splice_Site_p.R971_splice|ACE_ENST00000490216.2_Splice_Site_p.R397_splice|ACE_ENST00000290863.6_Splice_Site_p.R397_splice|ACE_ENST00000421982.2_Splice_Site_p.R217_splice			P12821	ACE_HUMAN	angiotensin I converting enzyme	971	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CAAGGACTTCCGGTACATCCA	0.607000													36	57					0	0	1	0	0
NFIA	4774	broad.mit.edu	37	1	61824847	61824847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:61824847G>A	ENST00000403491.3	+	6	1331	c.847G>A	c.(847-849)Gat>Aat	p.D283N	NFIA_ENST00000371184.2_Intron|NFIA_ENST00000371187.3_Missense_Mutation_p.D283N|NFIA_ENST00000371191.1_Missense_Mutation_p.D306N|NFIA_ENST00000485903.2_Missense_Mutation_p.D283N|NFIA_ENST00000371185.2_Missense_Mutation_p.D261N|NFIA_ENST00000371189.4_Missense_Mutation_p.D328N|NFIA_ENST00000479364.1_3'UTR|NFIA_ENST00000407417.3_Missense_Mutation_p.D275N	NM_001134673.3|NM_005595.4	NP_001128145.1|NP_005586.1	Q12857	NFIA_HUMAN	nuclear factor I/A	283					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding		NFIA/EHF(2)	endometrium(1)|kidney(2)|large_intestine(8)|lung(20)|pancreas(1)|prostate(1)|skin(1)	34						GTCTGTGGAGGATGAAATGGA	0.512000													14	186					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003043	122003043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122003043C>T	ENST00000498619.1	+	7	2710	c.2272C>T	c.(2272-2274)Ccg>Tcg	p.P758S	CASR_ENST00000296154.5_Missense_Mutation_p.P748S|CASR_ENST00000490131.1_Missense_Mutation_p.P748S	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	748					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CACCGCGCCCCCGTCAAGCTA	0.592000													23	49					0	0	1	0	0
ELK4	2005	broad.mit.edu	37	1	205592886	205592886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205592886G>A	ENST00000357992.4	-	2	464	c.125C>T	c.(124-126)gCt>gTt	p.A42V	ELK4_ENST00000468523.1_5'UTR|ELK4_ENST00000289703.4_Missense_Mutation_p.A42V	NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CCAGAGACGAGCCACCTCTTC	0.468000			T	SLC45A3	prostate								71	161					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149513291	149513291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149513291G>A	ENST00000261799.4	-	6	1261	c.792C>T	c.(790-792)ttC>ttT	p.F264F		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	264	Ig-like C2-type 3.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TATCCAAGAGGAAGTCAGTCA	0.602000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								42	112					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31374319	31374319	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31374319A>T	ENST00000328111.2	+	5	639	c.318A>T	c.(316-318)cgA>cgT	p.R106R	DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000344505.4_Silent_p.R106R|DNMT3B_ENST00000375623.4_Intron|DNMT3B_ENST00000201963.3_Silent_p.R118R|DNMT3B_ENST00000353855.2_Silent_p.R106R|DNMT3B_ENST00000348286.2_Silent_p.R106R|DNMT3B_ENST00000443239.3_Intron	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	106	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCCGAACTCGAAATAACAACA	0.632000													18	55					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71483463	71483463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71483463G>A	ENST00000393539.2	-	6	1278	c.465C>T	c.(463-465)ctC>ctT	p.L155L	ZNF23_ENST00000564528.1_Silent_p.L97L|ZNF23_ENST00000539742.1_5'UTR|RP11-510M2.10_ENST00000576258.1_RNA|ZNF23_ENST00000417828.1_Silent_p.L155L|ZNF23_ENST00000357254.4_Silent_p.L155L|AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000428724.2_Silent_p.L97L|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000497160.1_3'UTR	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		CATGCTTCACGAGTTTTGTAT	0.393000													27	91					0	0	1	0	0
INSL6	11172	broad.mit.edu	37	9	5185414	5185414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:5185414C>T	ENST00000381641.3	-	1	254	c.189G>A	c.(187-189)cgG>cgA	p.R63R		NM_007179.2	NP_009110.2	Q9Y581	INSL6_HUMAN	insulin-like 6	63						extracellular region	hormone activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(2)	15	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		GTGCAATCAACCGTGAGAAAG	0.572000													48	86					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74394620	74394620	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:74394620G>A	ENST00000429810.2	-	0	345																											CTCCACAGACGACCACCTGTG	0.582000													13	67					0	0	1	0	0
ANXA3	306	broad.mit.edu	37	4	79507429	79507429	+	Missense_Mutation	SNP	G	G	A	rs144530066	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79507429G>A	ENST00000264908.6	+	6	707	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	ANXA3_ENST00000512884.1_Missense_Mutation_p.E71K|ANXA3_ENST00000503570.2_Missense_Mutation_p.E71K	NM_005139.2	NP_005130.1	P12429	ANXA3_HUMAN	annexin A3	110					defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						GGGAACAAACGAAGATGCCTT	0.343000													28	100					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71485759	71485759	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:71485759C>T	ENST00000304743.2	+	12	3476	c.3030C>T	c.(3028-3030)gtC>gtT	p.V1010V	PCNX_ENST00000238570.5_Silent_p.V1010V|PCNX_ENST00000439984.3_Silent_p.V899V	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1010						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGTTAGCTGTCATCCTGGCTA	0.398000													49	130					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17927185	17927185	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:17927185G>A	ENST00000448223.2	-	3	298	c.29C>T	c.(28-30)tCc>tTc	p.S10F	SMC6_ENST00000351948.4_Missense_Mutation_p.S10F|SMC6_ENST00000402989.1_Missense_Mutation_p.S10F|SMC6_ENST00000381272.4_Missense_Mutation_p.S10F	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	10					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTTAGGAGAGGAAAAATTTTC	0.328000													7	25					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46946318	46946318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46946318G>A	ENST00000429979.1	-	3	897	c.293C>T	c.(292-294)tCc>tTc	p.S98F	KIAA0226L_ENST00000409879.2_Intron|KIAA0226L_ENST00000480935.1_5'UTR|KIAA0226L_ENST00000534925.1_5'UTR|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.S98F|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.S31F|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.S98F|KIAA0226L_ENST00000322896.6_Intron|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.S98F|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.S98F	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	98	Ser-rich.									NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						CTCTGCCAGGGAGTCCCCGAG	0.572000													31	61					0	0	1	0	0
APOL3	80833	broad.mit.edu	37	22	36556853	36556853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36556853G>A	ENST00000349314.2	-	1	124	c.87C>T	c.(85-87)ttC>ttT	p.F29F	APOL3_ENST00000424878.2_Intron|APOL3_ENST00000361710.2_Intron|APOL3_ENST00000397293.2_5'UTR|APOL3_ENST00000397287.2_Intron	NM_145640.2	NP_663615.1	O95236	APOL3_HUMAN	apolipoprotein L, 3	29					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity			endometrium(2)|large_intestine(1)|lung(1)|stomach(1)	5						ACCCAAAAGGGAAAGTGAAAG	0.537000													24	49					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	946159	946159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:946159C>T	ENST00000264771.4	+	7	568	c.383C>T	c.(382-384)tCg>tTg	p.S128L	TMEM175_ENST00000515740.1_Missense_Mutation_p.S12L|TMEM175_ENST00000504180.1_3'UTR|TMEM175_ENST00000508204.1_Missense_Mutation_p.S46L	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	128						integral to membrane		p.S128L(1)		NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TAACAGTTTTCGTTAATGGTG	0.562000													27	140					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	185969700	185969700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185969700C>T	ENST00000265022.3	-	19	2148	c.1609G>A	c.(1609-1611)Ggg>Agg	p.G537R	DGKG_ENST00000382164.4_Missense_Mutation_p.G498R|DGKG_ENST00000344484.4_Missense_Mutation_p.G512R|DGKG_ENST00000544847.1_Missense_Mutation_p.G478R	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	537	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity	p.G537W(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AAGCTGCCCCCTTCATAACCT	0.527000													11	93					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004186	75004186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:75004186C>T	ENST00000373359.2	-	1	893	c.701G>A	c.(700-702)cGa>cAa	p.R234Q		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	234	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTCCAAGAATCGCATGCACAC	0.488000													25	26					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54687454	54687454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54687454G>A	ENST00000245615.1	-	5	923	c.443C>T	c.(442-444)tCc>tTc	p.S148F	MBOAT7_ENST00000431666.2_Missense_Mutation_p.S75F|MBOAT7_ENST00000338624.6_Missense_Mutation_p.S75F|MBOAT7_ENST00000474910.1_5'UTR|MBOAT7_ENST00000391754.1_Missense_Mutation_p.S148F	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	148					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CTCCATCAGGGAGGGCACGTC	0.617000													10	78					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17449365	17449365	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17449365C>T	ENST00000324894.8	+	4	474	c.406C>T	c.(406-408)Cga>Tga	p.R136*	GTPBP3_ENST00000600625.1_Nonsense_Mutation_p.R136*|GTPBP3_ENST00000358792.7_Nonsense_Mutation_p.R136*|GTPBP3_ENST00000361619.5_Nonsense_Mutation_p.R158*|GTPBP3_ENST00000598038.1_3'UTR	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	136					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						GCCAGGGCTTCGACCGGCGGA	0.652000													14	55					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47515712	47515712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47515712G>A	ENST00000371901.3	+	12	1646	c.1396G>A	c.(1396-1398)Gta>Ata	p.V466I	CYP4X1_ENST00000538609.1_Missense_Mutation_p.V465I	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	466						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						TGAGTTAAAGGTAACCATTGC	0.438000													55	120					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64263654	64263654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:64263654G>A	ENST00000261891.3	-	3	426	c.421C>T	c.(421-423)Cac>Tac	p.H141Y	DAPK2_ENST00000457488.1_Missense_Mutation_p.H141Y|DAPK2_ENST00000558482.1_5'UTR|DAPK2_ENST00000558069.1_Missense_Mutation_p.H141Y			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	141	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		TTCTTTGTGTGAAGGTAGTTC	0.483000													24	338					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70954525	70954525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70954525C>T	ENST00000334414.6	-	17	4402	c.4358G>A	c.(4357-4359)gGa>gAa	p.G1453E	PTPRB_ENST00000550857.1_Missense_Mutation_p.G1145E|PTPRB_ENST00000451516.2_Missense_Mutation_p.G1145E|PTPRB_ENST00000551525.1_Missense_Mutation_p.G1452E|PTPRB_ENST00000550358.1_Missense_Mutation_p.G1365E|PTPRB_ENST00000538708.1_Missense_Mutation_p.G1145E|PTPRB_ENST00000261266.5_Missense_Mutation_p.G1235E	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1235	Fibronectin type-III 17.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTACTTCCTTCCAGGAACAAG	0.498000													15	43					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41608021	41608021	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41608021G>A	ENST00000313860.7	+	6	540	c.486_splice	c.e6+1	p.K162_splice	LIMCH1_ENST00000509638.1_Splice_Site_p.K3_splice|LIMCH1_ENST00000513024.1_Splice_Site_p.K3_splice|LIMCH1_ENST00000508501.1_Splice_Site_p.K162_splice|LIMCH1_ENST00000512946.1_Splice_Site_p.K162_splice|LIMCH1_ENST00000511496.1_Splice_Site_p.K3_splice|LIMCH1_ENST00000512820.1_Splice_Site_p.K162_splice|LIMCH1_ENST00000503057.1_Splice_Site_p.K3_splice|LIMCH1_ENST00000512632.1_Splice_Site_p.K162_splice	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	162					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						AGATGCGAAAGGTAACTTGGC	0.433000													10	31					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825532	4825532	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4825532G>A	ENST00000380382.1	-	1	315	c.316C>T	c.(316-318)Cag>Tag	p.Q106*	MMP26_ENST00000380390.1_Intron|OR52R1_ENST00000356069.2_Nonsense_Mutation_p.Q27*|MMP26_ENST00000477339.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCCACAACTGGAAACTCTCC	0.498000													13	43					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155566292	155566292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:155566292G>A	ENST00000295101.2	+	2	1357	c.880G>A	c.(880-882)Gag>Aag	p.E294K	KCNJ3_ENST00000493505.1_3'UTR|KCNJ3_ENST00000544049.1_Intron	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	294					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	TGAACAGTTCGAGATTGTCGT	0.408000													17	67					0	0	1	0	0
GLT8D2	83468	broad.mit.edu	37	12	104387281	104387281	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104387281C>T	ENST00000360814.4	-	10	1174	c.767_splice	c.e10-1	p.E257_splice	GLT8D2_ENST00000548660.1_Splice_Site_p.E257_splice|GLT8D2_ENST00000546436.1_Splice_Site_p.E257_splice	NM_031302.3	NP_112592.1	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	257						integral to membrane	transferase activity, transferring glycosyl groups			kidney(3)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						TAGAGGTTTTCCCTAAGAAAT	0.438000													9	25					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159163754	159163754	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159163754G>A	ENST00000368125.4	+	5	772	c.615G>A	c.(613-615)gcG>gcA	p.A205A	CADM3_ENST00000368124.4_Silent_p.A239A	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	205	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity	p.A239A(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					ATGATGGGGCGAGCATCGTGT	0.502000													29	59					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760190	115760190	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:115760190C>T	ENST00000427548.1	-	0	1623							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										AGTATGGATTCTCTCATGATT	0.383000													17	28					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128680643	128680643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128680643G>A	ENST00000344954.6	+	9	1408	c.1020G>A	c.(1018-1020)ccG>ccA	p.P340P	FLI1_ENST00000429175.2_Silent_p.P373P|FLI1_ENST00000534087.1_Silent_p.P340P|FLI1_ENST00000281428.8_Silent_p.P307P|FLI1_ENST00000525560.1_Silent_p.P180P			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	373					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		AGCCACATCCGACCGAGTCGT	0.478000			T	EWSR1	Ewing sarcoma								10	40					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53664532	53664532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53664532C>T	ENST00000257934.4	+	5	1410	c.1319C>T	c.(1318-1320)gCc>gTc	p.A440V	ESPL1_ENST00000552462.1_Missense_Mutation_p.A440V	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	440					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						ATGCTGGAGGCCTTAGAGGGC	0.552000													33	76					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139216447	139216447	+	Silent	SNP	C	C	T	rs143306197		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139216447C>T	ENST00000274710.3	+	10	1660	c.1455C>T	c.(1453-1455)ttC>ttT	p.F485F		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	485					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity	p.F485F(1)		breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAAGTTCGGGACAGGCA	0.607000													36	71					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082977	9082977	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9082977C>T	ENST00000397910.4	-	1	9041	c.8838G>A	c.(8836-8838)aaG>aaA	p.K2946K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2947	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACTTATGGCCTTTGTGGAAG	0.498000													24	66					0	0	1	0	0
TMEM82	388595	broad.mit.edu	37	1	16069654	16069654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16069654C>T	ENST00000375782.1	+	3	439	c.301C>T	c.(301-303)Ctc>Ttc	p.L101F	RP11-169K16.4_ENST00000418525.1_RNA|TMEM82_ENST00000465575.1_3'UTR	NM_001013641.1	NP_001013663.1	A0PJX8	TMM82_HUMAN	transmembrane protein 82	101	Leu-rich.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|lung(5)|prostate(1)|skin(1)	13		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CGAGTTCTCCCTCCGGGCCGT	0.711000													13	26					0	0	1	0	0
KRTAP19-3	337970	broad.mit.edu	37	21	31864206	31864206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31864206C>T	ENST00000334063.4	-	1	69	c.70G>A	c.(70-72)Ggc>Agc	p.G24S		NM_181609.3	NP_853640.1	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	24						intermediate filament				large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	9						CAGCCATAGCCATAGCCCAGG	0.572000													81	225					0	0	1	0	0
RASL10B	91608	broad.mit.edu	37	17	34067503	34067503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34067503G>A	ENST00000268864.3	+	3	669	c.292G>A	c.(292-294)Gac>Aac	p.D98N		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	98	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGCTGCTTTGACAGCTTTGA	0.582000													33	57					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71977812	71977812	+	Silent	SNP	G	G	A	rs141274411		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71977812G>A	ENST00000266674.5	+	18	2333	c.2022G>A	c.(2020-2022)acG>acA	p.T674T	LGR5_ENST00000536515.1_Silent_p.T602T|LGR5_ENST00000540815.2_Silent_p.T650T			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	674						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						AATTTGAAACGAAAGCTCCAT	0.478000													42	168					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004535	75004535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:75004535G>A	ENST00000373359.2	-	1	544	c.352C>T	c.(352-354)Ctc>Ttc	p.L118F		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	118	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TACTCTCTGAGAAACTCCAGC	0.507000													12	19					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072667	17072667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17072667C>T	ENST00000359963.3	-	1	1033	c.774G>A	c.(772-774)acG>acA	p.T258T		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	258					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AAAGACGGGCCGTTGCTGGTG	0.507000													40	96					0	0	1	0	0
CEPT1	10390	broad.mit.edu	37	1	111724867	111724867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111724867C>T	ENST00000545121.1	+	6	981	c.773C>T	c.(772-774)aCc>aTc	p.T258I	CEPT1_ENST00000467362.1_3'UTR|CEPT1_ENST00000357172.4_Missense_Mutation_p.T258I	NM_001007794.1	NP_001007795.1	Q9Y6K0	CEPT1_HUMAN	choline/ethanolamine phosphotransferase 1	258						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	8		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)	GTAGCAGGGACCATATTTTCC	0.338000													17	48					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77944600	77944600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77944600C>T	ENST00000393684.3	-	7	1310	c.919G>A	c.(919-921)Gac>Aac	p.D307N	ISM2_ENST00000429906.1_Missense_Mutation_p.D314N|ISM2_ENST00000412904.1_Missense_Mutation_p.D314N|ISM2_ENST00000493585.1_Silent_p.R279R|ISM2_ENST00000342219.4_Missense_Mutation_p.D395N			Q6H9L7	ISM2_HUMAN	isthmin 2	395						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						TCATGCATGTCCGTAGCATTG	0.602000													24	127					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80631636	80631636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:80631636G>A	ENST00000307624.3	-	12	1241	c.1213C>T	c.(1213-1215)Cgt>Tgt	p.R405C	ACOT12_ENST00000508234.1_5'UTR	NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	405	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		GACAAGAGACGATAAGCCAAA	0.348000													32	102					0	0	1	0	0
HDHD3	81932	broad.mit.edu	37	9	116136320	116136320	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116136320G>A	ENST00000238379.5	-	2	1212	c.315C>T	c.(313-315)ttC>ttT	p.F105F	HDHD3_ENST00000485934.1_5'UTR|HDHD3_ENST00000374180.3_Silent_p.F105F	NM_031219.2	NP_112496.1	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain containing 3	105							phosphoglycolate phosphatase activity|protein binding			large_intestine(2)|liver(1)	3						AGGGGTGGCTGAAGTCTTTAT	0.607000													32	115					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18807896	18807896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18807896C>T	ENST00000400664.1	+	1	473	c.421C>T	c.(421-423)Ccc>Tcc	p.P141S		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	141			P -> R (in dbSNP:rs2992755).			integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTTGCTGCCCCAGCCAGGA	0.642000													20	47					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48634378	48634378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48634378G>A	ENST00000435803.1	+	58	14737	c.14713G>A	c.(14713-14715)Gaa>Aaa	p.E4905K	ABCA13_ENST00000544596.1_Missense_Mutation_p.E635K	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4905	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGAGGTTCGGGAAGGCTGTGC	0.488000													43	97					0	0	1	0	0
NXPE2	120406	broad.mit.edu	37	11	114569186	114569186	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:114569186G>A	ENST00000375475.5	+	3	650	c.552G>A	c.(550-552)gaG>gaA	p.E184E	NXPE2_ENST00000389586.4_Silent_p.E184E					neurexophilin and PC-esterase domain family, member 2																		TGTTCTGGGAGGGCCAGGTTT	0.547000													8	36					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72324887	72324887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72324887G>A	ENST00000356056.5	-	3	1355	c.883C>T	c.(883-885)Cgt>Tgt	p.R295C	MYO9A_ENST00000566885.1_5'UTR|MYO9A_ENST00000424560.1_Missense_Mutation_p.R295C|MYO9A_ENST00000563542.1_5'UTR|RP11-390D11.1_ENST00000568391.1_RNA|MYO9A_ENST00000564571.1_Missense_Mutation_p.R295C|MYO9A_ENST00000444904.1_Missense_Mutation_p.R295C	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	295	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTCCCAAAACGACTTGAATTG	0.333000													12	78					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999795	112999795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112999795C>T	ENST00000271277.6	+	6	1906	c.1681C>T	c.(1681-1683)Ccc>Tcc	p.P561S	RP4-671G15.3_ENST00000508462.1_RNA|CTTNBP2NL_ENST00000607039.1_3'UTR	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	561						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCCCCTGAGCCCCCTGTCTCC	0.557000													29	89					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89949407	89949407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89949407C>T	ENST00000405460.2	+	20	4112	c.4016C>T	c.(4015-4017)aCt>aTt	p.T1339I		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1339					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCATTTGGGACTGTTAATCCA	0.448000													13	25					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71008381	71008381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71008381C>T	ENST00000354624.5	+	10	1600	c.1467C>T	c.(1465-1467)gcC>gcT	p.A489A	HKDC1_ENST00000395086.2_Silent_p.A489A|HKDC1_ENST00000488706.1_3'UTR	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	489					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						ACGTGCAGGCCAAGATGCGGG	0.667000													10	33					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656476	40656476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:40656476C>T	ENST00000406785.1	-	2	1134	c.945G>A	c.(943-945)agG>agA	p.R315R	SLC8A1_ENST00000408028.2_Silent_p.R315R|SLC8A1_ENST00000542756.1_Silent_p.R315R|SLC8A1_ENST00000542024.1_Silent_p.R315R|SLC8A1_ENST00000403092.1_Silent_p.R315R|SLC8A1_ENST00000405901.3_Silent_p.R315R|SLC8A1_ENST00000405269.1_Silent_p.R315R|SLC8A1_ENST00000332839.4_Silent_p.R315R|SLC8A1_ENST00000402441.1_Silent_p.R315R|SLC8A1_ENST00000406391.2_Silent_p.R315R			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	315					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CATCTTGGTCCCTCTCATCCA	0.408000													72	159					0	0	1	0	0
CYS1	192668	broad.mit.edu	37	2	10199021	10199021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:10199021C>T	ENST00000381813.4	-	3	623	c.436G>A	c.(436-438)Gag>Aag	p.E146K	CYS1_ENST00000477304.1_5'UTR	NM_001037160.2	NP_001032237.1	Q717R9	CYS1_HUMAN	cystin 1	146						cilium axoneme				large_intestine(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.166)|OV - Ovarian serous cystadenocarcinoma(76;0.227)		ATCAGCCCCTCTTCCGAGTGG	0.677000													8	5					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110478892	110478892	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110478892C>T	ENST00000378402.5	+	50	8603	c.8499C>T	c.(8497-8499)ttC>ttT	p.F2833F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2833					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCATTGGGTTCCCTGGATCAG	0.478000										HNSCC(38;0.096)			6	15					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36789956	36789956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36789956C>T	ENST00000361475.2	-	2	229	c.56G>A	c.(55-57)cGa>cAa	p.R19Q	TGM2_ENST00000536701.1_Missense_Mutation_p.R19Q|TGM2_ENST00000536724.1_Intron	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	19					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	GTGGTGGTCTCGGCCATTGGT	0.622000													38	94					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4391133	4391133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4391133G>A	ENST00000355530.2	+	12	1763	c.1483G>A	c.(1483-1485)Gac>Aac	p.D495N	SPNS3_ENST00000333476.2_Missense_Mutation_p.D368N	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	495					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GGACAGCAACGACCTGGAGAG	0.622000													59	68					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56086308	56086308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56086308C>T	ENST00000312711.1	+	1	526	c.526C>T	c.(526-528)Cat>Tat	p.H176Y		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					CGTCATTAGTCATTTCTACTG	0.358000													25	79					0	0	1	0	0
NCMAP	400746	broad.mit.edu	37	1	24921982	24921982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24921982G>A	ENST00000374392.2	+	2	127	c.61G>A	c.(61-63)Gga>Aga	p.G21R	NCMAP_ENST00000486262.1_3'UTR	NM_001010980.4	NP_001010980.1			noncompact myelin associated protein																		GACCACCAGGGGAGAAGACTT	0.473000													13	52					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12187389	12187389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12187389C>T	ENST00000439326.3	+	4	1629	c.1454C>T	c.(1453-1455)tCa>tTa	p.S485L	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	485					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						GTAAAGCCTTCATTTTTTCCA	0.448000													38	70					0	0	1	0	0
PYCR2	29920	broad.mit.edu	37	1	226108237	226108237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226108237G>A	ENST00000343818.6	-	7	1029	c.881C>T	c.(880-882)tCc>tTc	p.S294F	RP4-559A3.7_ENST00000432920.2_Intron|PYCR2_ENST00000478402.1_5'UTR	NM_013328.2	NP_037460.2	Q96C36	P5CR2_HUMAN	pyrroline-5-carboxylate reductase family, member 2	294					proline biosynthetic process	cytoplasm	binding|pyrroline-5-carboxylate reductase activity			kidney(1)|lung(3)	4	Breast(184;0.197)				L-Proline(DB00172)|NADH(DB00157)	GACTGTGGGGGATTCCAGCTT	0.572000													50	108					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69817442	69817442	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69817442G>A	ENST00000251566.4	-	1	67	c.37C>T	c.(37-39)Ctg>Ttg	p.L13L		NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	13						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AAGAGCTGCAGGAGCAGAAAT	0.468000													13	44					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86954832	86954832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86954832G>A	ENST00000234701.3	+	9	1687	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	CLCA1_ENST00000394711.1_Missense_Mutation_p.E446K			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	446	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TCAAGAACTAGAGGAGCTGTC	0.527000													7	44					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47225277	47225277	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47225277G>A	ENST00000391910.3	-	16	2529	c.2079C>T	c.(2077-2079)gcC>gcT	p.A693A	STRN4_ENST00000539396.1_Silent_p.A567A|STRN4_ENST00000263280.6_Silent_p.A686A			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	686						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		TGGGGTCCACGGCTAGGCAGG	0.632000													34	70					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12666919	12666919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12666919C>T	ENST00000425538.1	+	14	3119	c.2919C>T	c.(2917-2919)ctC>ctT	p.L973L	MYOCD_ENST00000343344.4_Silent_p.L925L|RP11-1090M7.1_ENST00000584772.1_RNA	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	925					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCACTGATCTCAATTTGAATT	0.522000													14	31					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15978098	15978098	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:15978098G>A	ENST00000262101.5	-	9	1172	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	MSR1_ENST00000445506.2_Nonsense_Mutation_p.R369*|MSR1_ENST00000350896.3_Intron|MSR1_ENST00000355282.2_Intron			P21757	MSRE_HUMAN	macrophage scavenger receptor 1	351	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity	p.R351R(1)		haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCGACCAGTCGAACTTTCGTA	0.453000													22	55					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76739023	76739023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76739023C>T	ENST00000287239.4	+	10	2646	c.2157C>T	c.(2155-2157)taC>taT	p.Y719Y	KAT6B_ENST00000372714.1_Silent_p.Y427Y|KAT6B_ENST00000372725.1_Silent_p.Y427Y|KAT6B_ENST00000490365.1_3'UTR|KAT6B_ENST00000372724.1_Silent_p.Y427Y|KAT6B_ENST00000372711.1_Silent_p.Y536Y	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	719	Catalytic.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										GTGGCCGGTACCCTTCTGTGA	0.388000													20	56					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79382659	79382659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79382659C>T	ENST00000419573.3	-	1	456	c.182G>A	c.(181-183)cGg>cAg	p.R61Q	RASGRF1_ENST00000558480.2_Missense_Mutation_p.R61Q	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	61	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CCCCGAGGGCCGCGAGCTCGA	0.637000													49	52					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105167206	105167206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105167206G>A	ENST00000428173.2	+	18	3013	c.2710G>A	c.(2710-2712)Gat>Aat	p.D904N	NRK_ENST00000243300.9_Missense_Mutation_p.D903N			Q7Z2Y5	NRK_HUMAN	Nik related kinase	903							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						CTTCCGGAATGATTGGTTAAC	0.428000										HNSCC(51;0.14)			24	24					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175463	143175463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143175463G>A	ENST00000408916.1	+	1	498	c.498G>A	c.(496-498)ggG>ggA	p.G166G	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	166					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					AATTTTCTGGGAACATGACCT	0.383000													17	49					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35587930	35587930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35587930C>T	ENST00000542713.1	-	4	529	c.372G>A	c.(370-372)tcG>tcA	p.S124S	FKBP5_ENST00000357266.4_Silent_p.S124S|FKBP5_ENST00000540787.1_Intron|FKBP5_ENST00000536438.1_Silent_p.S124S|FKBP5_ENST00000539068.1_Silent_p.S124S	NM_001145777.1	NP_001139249.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	124	PPIase FKBP-type 1.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						GAGTTGCATTCGAGGGAATTT	0.453000													33	83					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233410387	233410387	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233410387C>A	ENST00000389494.3	+	12	1536	c.1515C>A	c.(1513-1515)ttC>ttA	p.F505L	CHRNG_ENST00000389492.3_Missense_Mutation_p.F453L	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	505					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CCCTGCCATTCCCTGGAGATC	0.607000													8	80					0.00829132	0.00829502	1	1	0
PABPC4	8761	broad.mit.edu	37	1	40027429	40027429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40027429G>A	ENST00000372857.3	-	15	2668	c.1876C>T	c.(1876-1878)Cat>Tat	p.H626Y	PABPC4_ENST00000372858.3_Missense_Mutation_p.H642Y|PABPC4_ENST00000372856.3_Missense_Mutation_p.H613Y|PABPC4_ENST00000372862.3_Missense_Mutation_p.H597Y	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	626	PABC.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTGGCATGATGAGCCTGTAGA	0.502000													19	59					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124281801	124281801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124281801G>A	ENST00000360013.3	+	34	5168	c.5041G>A	c.(5041-5043)Gag>Aag	p.E1681K	KALRN_ENST00000393496.1_Missense_Mutation_p.E54K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1681	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.E1681*(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCGGCCCAGCGAGCGGCCTGG	0.657000													12	36					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2769796	2769796	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:2769796C>T	ENST00000320876.6	+	38	5162	c.4824C>T	c.(4822-4824)atC>atT	p.I1608I	SMCHD1_ENST00000261598.8_Silent_p.I1608I|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1608					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						AACCATATATCCTACCGTTCA	0.363000													5	10					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413721	72413721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72413721C>T	ENST00000395270.1	+	14	3435	c.2394C>T	c.(2392-2394)gtC>gtT	p.V798V	POM121_ENST00000257622.4_Silent_p.V798V|POM121_ENST00000434423.2_Silent_p.V1063V|POM121_ENST00000358357.3_Silent_p.V798V|POM121_ENST00000446813.1_Silent_p.V798V	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1063	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				CCACTGCTGTCTTCTTCGGTG	0.662000													11	60					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154271117	154271117	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154271117G>A	ENST00000285873.7	-	26	4021	c.3946C>T	c.(3946-3948)Cag>Tag	p.Q1316*		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	1316					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCTAACTGCTGGCTTGGCTCA	0.517000													56	85					0	0	1	0	0
SLC1A7	6512	broad.mit.edu	37	1	53556411	53556411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53556411G>A	ENST00000371494.4	-	8	1226	c.1099C>T	c.(1099-1101)Cgc>Tgc	p.R367C	SLC1A7_ENST00000488036.1_5'UTR	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	367						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	AGCACGAAGCGAGCGATGCGC	0.622000													15	26					0	0	1	0	0
SDSL	113675	broad.mit.edu	37	12	113875773	113875773	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113875773C>T	ENST00000403593.4	+	8	1141	c.879C>T	c.(877-879)gcC>gcT	p.A293A	SDSL_ENST00000345635.4_Silent_p.A293A			Q96GA7	SDSL_HUMAN	serine dehydratase-like	293					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	GGCTCCAGGCCGAGGGCTGCC	0.607000													70	253					0	0	1	0	0
OLIG3	167826	broad.mit.edu	37	6	137815305	137815305	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:137815305C>T	ENST00000367734.2	-	1	226	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	1					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		AATCAGAATTCATTTTATTAC	0.493000													28	39					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178564819	178564819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178564819G>A	ENST00000251582.7	-	12	2003	c.1902C>T	c.(1900-1902)ttC>ttT	p.F634F		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	634	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CGCCGTGCTCGAAGTACAGGT	0.692000													3	8					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6467622	6467622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6467622C>T	ENST00000381480.2	-	23	2411	c.2299G>A	c.(2299-2301)Gaa>Aaa	p.E767K	DENND1C_ENST00000543576.1_Missense_Mutation_p.E723K	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	767						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GCTCCTGGTTCCTCCCGTGGC	0.622000													19	34					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117662894	117662894	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117662894G>A	ENST00000317775.6	-	25	4438	c.3753C>T	c.(3751-3753)ctC>ctT	p.L1251L	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.L1285L	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1251					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTGGTCCAACGAGGATGCAGG	0.572000													49	121					0	0	1	0	0
SCRN1	9805	broad.mit.edu	37	7	29980386	29980386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:29980386C>T	ENST00000426154.1	-	5	827	c.651G>A	c.(649-651)gaG>gaA	p.E217E	SCRN1_ENST00000416113.2_Intron|SCRN1_ENST00000242059.5_Silent_p.E217E|SCRN1_ENST00000409497.1_Silent_p.E217E	NM_001145513.1	NP_001138985.1	Q12765	SCRN1_HUMAN	secernin 1	217					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(2)|prostate(2)|skin(2)	25						TGAACTCGCCCTCTCCCGTCC	0.493000													56	156					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32017145	32017145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32017145G>A	ENST00000375244.3	-	28	9860	c.9659C>T	c.(9658-9660)aCc>aTc	p.T3220I	TNXB_ENST00000375247.2_Missense_Mutation_p.T3218I			P22105	TENX_HUMAN	tenascin XB	3265	Fibronectin type-III 24.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCCCCCCACGGTGACCTCGCT	0.687000													23	38					0	0	1	0	0
HBZ	3050	broad.mit.edu	37	16	202971	202971	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:202971G>A	ENST00000252951.2	+	1	286	c.63G>A	c.(61-63)caG>caA	p.Q21Q		NM_005332.2	NP_005323.1	P02008	HBAZ_HUMAN	hemoglobin, zeta	21						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;4.28e-07)|all_epithelial(16;2.09e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				TCTCCACGCAGGCCGACACCA	0.627000													5	29					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149456979	149456979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149456979G>A	ENST00000286301.3	-	6	1040	c.749C>T	c.(748-750)tCt>tTt	p.S250F	CSF1R_ENST00000543093.1_Missense_Mutation_p.S250F	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	250	Ig-like C2-type 3.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	ATGAAAGTCAGATTGTTGAGG	0.463000													46	130					0	0	1	0	0
ABHD2	11057	broad.mit.edu	37	15	89738534	89738534	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89738534C>T	ENST00000352732.5	+	11	1678	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F	ABHD2_ENST00000565973.1_Silent_p.F386F|ABHD2_ENST00000355100.3_Silent_p.F386F	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	386						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					CTGTGCTGTTCCCCGAGCCCC	0.572000													22	80					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263426	140263426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140263426C>T	ENST00000289272.2	+	1	1573	c.1573C>T	c.(1573-1575)Cac>Tac	p.H525Y	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.H525Y|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGTTGGACCACGAGGAGCT	0.682000													18	193					0	0	1	0	0
ACSM3	6296	broad.mit.edu	37	16	20803324	20803324	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20803324G>A	ENST00000289416.5	+	11	1802	c.1326_splice	c.e11-1	p.D443_splice	ACSM3_ENST00000450120.2_Splice_Site_p.D435_splice|ERI2_ENST00000300005.3_Intron|ACSM3_ENST00000567387.1_3'UTR	NM_005622.3	NP_005613.2	Q53FZ2	ACSM3_HUMAN	acyl-CoA synthetase medium-chain family member 3	443					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	21						TGTTTTGCAGGATAATCCTTC	0.368000													38	66					0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19378024	19378024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:19378024C>T	ENST00000550708.1	+	1	503	c.431C>T	c.(430-432)cCc>cTc	p.P144L		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCTGCCGTCCCTTGCTCTAT	0.448000													41	121					0	0	1	0	0
ALKBH4	54784	broad.mit.edu	37	7	102097929	102097929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:102097929G>A	ENST00000292566.3	-	3	860	c.821C>T	c.(820-822)tCg>tTg	p.S274L		NM_017621.3	NP_060091.1	Q9NXW9	ALKB4_HUMAN	alkB, alkylation repair homolog 4 (E. coli)	274						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(5)|skin(2)	8						AAACTCAGCCGACAGCTCCCG	0.667000													14	37					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12125274	12125274	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:12125274C>T	ENST00000379388.2	+	4	5578	c.5246C>T	c.(5245-5247)tCc>tTc	p.S1749F		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1749					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGATGCTTTCCCCAGCAAAT	0.433000													14	85					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16757789	16757789	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16757789C>T	ENST00000375577.1	-	2	417	c.78G>A	c.(76-78)agG>agA	p.R26R	SPATA21_ENST00000335496.1_Intron|SPATA21_ENST00000540400.1_Intron|SPATA21_ENST00000466212.1_5'UTR			Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	27							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TTATGGTGATCCTCAGGCCAG	0.567000													13	30					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123687318	123687318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:123687318C>T	ENST00000334268.4	-	20	1600	c.1283G>A	c.(1282-1284)cGa>cAa	p.R428Q	TRDN_ENST00000398178.3_Missense_Mutation_p.R428Q			Q13061	TRDN_HUMAN	triadin	428					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		CTCTTTGGCTCGTTCAGTTTC	0.308000													8	14					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046475	73046475	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73046475G>A	ENST00000604411.1	+	0	34436				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GTAGGGTTTAGGGTTCTCATC	0.423000													72	54					0	0	1	0	0
SPTLC1	10558	broad.mit.edu	37	9	94809925	94809925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:94809925G>A	ENST00000262554.2	-	10	959	c.954C>T	c.(952-954)tgC>tgT	p.C318C		NM_006415.2	NP_006406.1	O15269	SPTC1_HUMAN	serine palmitoyltransferase, long chain base subunit 1	318						integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACCTGCCACAGCAGAAACCTC	0.393000													7	32					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168112740	168112740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168112740C>T	ENST00000519560.1	-	31	3926	c.3507G>A	c.(3505-3507)gtG>gtA	p.V1169V	SLIT3_ENST00000332966.8_Silent_p.V1176V|SLIT3_ENST00000404867.3_Silent_p.V1169V	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1169	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGCCAGTTCCACGTAGGAGT	0.642000													22	58					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41648155	41648155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41648155C>T	ENST00000400454.1	-	11	2702	c.2225G>A	c.(2224-2226)cGa>cAa	p.R742Q		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	742	Ig-like C2-type 8.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AACTTGGATTCGGCCATTTAG	0.512000													27	39					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142574244	142574244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142574244C>T	ENST00000359396.3	-	6	924	c.679G>A	c.(679-681)Gac>Aac	p.D227N	RP11-114L10.2_ENST00000438839.1_RNA	NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	227					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					TGCAGGTGGTCCCCATGTCTG	0.572000													25	48					0	0	1	0	0
IL20RB	53833	broad.mit.edu	37	3	136708326	136708326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:136708326C>T	ENST00000329582.4	+	4	699	c.450C>T	c.(448-450)ttC>ttT	p.F150F	IL20RB_ENST00000309741.5_Silent_p.F103F|IL20RB_ENST00000484501.1_3'UTR	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	150	Fibronectin type-III 2.					integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						AAGATGGCTTCCACCTGGTTA	0.582000													17	58					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58129186	58129186	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58129186C>T	ENST00000257897.3	-	2	270	c.185G>A	c.(184-186)tGg>tAg	p.W62*	AGAP2_ENST00000547588.1_Nonsense_Mutation_p.W398*	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	398					axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						GCTCAAAGTCCATTCCTGGCT	0.592000													3	24					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038981	75038981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75038981G>A	ENST00000326665.5	-	14	2631	c.2413C>T	c.(2413-2415)Cat>Tat	p.H805Y	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	805	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGAGCCTCATGAACAGCTCCT	0.537000													47	123					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56712110	56712110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56712110G>A	ENST00000425394.2	-	25	3861	c.3485C>T	c.(3484-3486)tCt>tTt	p.S1162F	PAN2_ENST00000440411.3_Missense_Mutation_p.S1158F|PAN2_ENST00000257931.5_Missense_Mutation_p.S1161F|PAN2_ENST00000549090.1_5'UTR|PAN2_ENST00000548043.1_Missense_Mutation_p.S1162F	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	1162					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CTTGTGGAAAGACTCAGGCTC	0.512000													33	132					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50560661	50560661	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50560661G>A	ENST00000380984.4	-	10	1049	c.987C>T	c.(985-987)tgC>tgT	p.C329C	DDC_ENST00000357936.5_Intron|DDC_ENST00000431062.1_Intron|DDC_ENST00000426377.1_Intron|DDC_ENST00000444124.2_Intron	NM_001242890.1	NP_001229819.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CACTGACTAAGCAGGTTTTCT	0.557000													10	17					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38917344	38917344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38917344C>T	ENST00000359357.3	+	79	11849	c.11595C>T	c.(11593-11595)atC>atT	p.I3865I	RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Silent_p.I4082I|DNAH8_ENST00000441566.1_Silent_p.I3829I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTTTACTTATCAGGTGAGAAC	0.363000													17	86					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38106446	38106446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38106446C>T	ENST00000406386.3	+	4	382	c.127C>T	c.(127-129)Cct>Tct	p.P43S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	43					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GCTCAGGAGCCCTTCAGGTGC	0.687000													14	26					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72338847	72338847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72338847G>A	ENST00000389916.4	+	4	448	c.310G>A	c.(310-312)Ggc>Agc	p.G104S		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	104	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CTTTGCCTATGGCCCCACAGG	0.592000													25	55					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605214	140605214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140605214C>T	ENST00000239449.4	+	1	2137	c.2137C>T	c.(2137-2139)Ctg>Ttg	p.L713L	PCDHB14_ENST00000515856.2_Silent_p.L560L	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		713					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGGTGCGGCTGTGCAGGAG	0.692000													46	245					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58240849	58240849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58240849G>A	ENST00000377918.3	+	3	2705	c.2679G>A	c.(2677-2679)ggG>ggA	p.G893G		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	893					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GTGGGCACGGGGACAGTGATC	0.448000													15	71					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41725472	41725472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41725472G>A	ENST00000400454.1	-	5	1331	c.854C>T	c.(853-855)cCc>cTc	p.P285L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	285	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGAGTCCGAGGGGCGAATGTT	0.537000													29	94					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95088716	95088716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95088716C>T	ENST00000553947.1	+	7	1919	c.1031C>T	c.(1030-1032)tCg>tTg	p.S344L	SERPINA3_ENST00000467132.1_Missense_Mutation_p.S319L|SERPINA3_ENST00000482740.1_Missense_Mutation_p.S101L|SERPINA3_ENST00000393080.4_Missense_Mutation_p.S319L|SERPINA3_ENST00000556388.1_3'UTR|SERPINA3_ENST00000393078.3_Missense_Mutation_p.S319L			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	319					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity	p.S319L(1)		NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TTTTCCATCTCGAGGGACTAT	0.498000													27	105					0	0	1	0	0
C21orf128	150147	broad.mit.edu	37	21	43524025	43524025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43524025G>A	ENST00000329015.2	-	2	359	c.208C>T	c.(208-210)Ccc>Tcc	p.P70S	UMODL1_ENST00000400424.1_Silent_p.G377G|UMODL1_ENST00000408910.2_Silent_p.G449G|UMODL1_ENST00000408989.2_Silent_p.G449G|UMODL1_ENST00000400427.1_Silent_p.G377G					chromosome 21 open reading frame 128											lung(4)	4						ACCGAAGTGGGAAGCTGAGAA	0.567000													40	100					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87912231	87912231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87912231G>A	ENST00000380079.4	-	3	810	c.709C>T	c.(709-711)Cgt>Tgt	p.R237C	STEAP4_ENST00000414498.1_Missense_Mutation_p.R237C|AC003991.3_ENST00000434733.1_RNA|AC003991.3_ENST00000447758.1_RNA|STEAP4_ENST00000301959.5_Intron|AC003991.3_ENST00000600908.1_RNA|AC003991.3_ENST00000595121.1_RNA	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	237					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					ATAGCCATACGAAATGTATTA	0.363000													31	99					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093066	30093066	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30093066C>T	ENST00000567636.1	+	0	1441					NR_003558.1																						TGGACCACCTCCAGGAGCTCC	0.582000													5	11					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207107939	207107939	+	Missense_Mutation	SNP	C	C	T	rs141320420	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207107939C>T	ENST00000356495.4	-	6	1714	c.1531G>A	c.(1531-1533)Gaa>Aaa	p.E511K		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	511	Ig-like V-type 5.					extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTGGGGCCTTCGTCTTGGCTG	0.577000													46	88					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54919034	54919034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54919034G>A	ENST00000545554.1	+	32	6368	c.6368G>A	c.(6367-6369)gGa>gAa	p.G2123E	UNC13C_ENST00000537900.1_Missense_Mutation_p.G2121E|UNC13C_ENST00000539562.2_Missense_Mutation_p.G44E|UNC13C_ENST00000260323.11_Missense_Mutation_p.G2123E			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2123	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.G2123E(2)		breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGCATTCTCGGAAAGGAAAAT	0.373000													8	35					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97170471	97170471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97170471G>A	ENST00000371247.2	-	10	1063	c.874C>T	c.(874-876)Cca>Tca	p.P292S	SORBS1_ENST00000361941.3_Missense_Mutation_p.P292S|SORBS1_ENST00000393949.1_Missense_Mutation_p.P283S|SORBS1_ENST00000354106.3_Missense_Mutation_p.P283S|SORBS1_ENST00000371245.3_Missense_Mutation_p.P223S|SORBS1_ENST00000371227.4_Missense_Mutation_p.P292S|SORBS1_ENST00000371241.1_Missense_Mutation_p.P128S|SORBS1_ENST00000607232.1_Missense_Mutation_p.P137S|SORBS1_ENST00000306402.6_Missense_Mutation_p.P169S|SORBS1_ENST00000371249.2_Missense_Mutation_p.P260S|SORBS1_ENST00000371239.1_Missense_Mutation_p.P137S|SORBS1_ENST00000347291.4_Missense_Mutation_p.P160S|SORBS1_ENST00000277982.5_Missense_Mutation_p.P292S|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000353505.5_Missense_Mutation_p.P223S|SORBS1_ENST00000371246.2_Missense_Mutation_p.P292S			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	292				PSVS -> SSEC (in Ref. 1; AAD27647 and 3; AAF22175).	focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CTAACTGATGGAAAGGCTTGG	0.428000													19	71					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84605985	84605985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84605985C>T	ENST00000344803.2	+	4	647	c.600C>T	c.(598-600)ctC>ctT	p.L200L		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CCTTAATTCTCTCACCTGACC	0.552000													44	75					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169698458	169698458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169698458G>A	ENST00000333360.7	-	7	1098	c.959C>T	c.(958-960)tCc>tTc	p.S320F	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367775.1_Missense_Mutation_p.S258F|SELE_ENST00000367774.1_Missense_Mutation_p.S320F|SELE_ENST00000367782.4_Missense_Mutation_p.S320F|SELE_ENST00000367779.4_Missense_Mutation_p.S320F|SELE_ENST00000367781.4_Missense_Mutation_p.S320F|SELE_ENST00000367777.1_Missense_Mutation_p.S320F|SELE_ENST00000367776.1_Missense_Mutation_p.S320F|SELE_ENST00000367780.4_Missense_Mutation_p.S258F	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	320	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TCCAGCAGGGGAATGGCTGCA	0.522000													10	37					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24529224	24529224	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24529224C>T	ENST00000342740.5	+	23	2068	c.1914C>T	c.(1912-1914)tcC>tcT	p.S638S	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	638										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GCGACATCTCCCAAGCCTATC	0.662000													32	129					0	0	1	0	0
VSX2	338917	broad.mit.edu	37	14	74711967	74711967	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74711967G>A	ENST00000261980.2	+	3	645	c.555G>A	c.(553-555)acG>acA	p.T185T		NM_182894.2	NP_878314.1	P58304	VSX2_HUMAN	visual system homeobox 2	185					multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00154)		CCATGAAAACGGAGCTGCCGG	0.577000													15	55					0	0	1	0	0
AMER2	219287	broad.mit.edu	37	13	25744230	25744230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25744230C>T	ENST00000357816.2	-	3	1646	c.1171G>A	c.(1171-1173)Gag>Aag	p.E391K	AMER2_ENST00000381853.3_Missense_Mutation_p.E391K|AMER2_ENST00000515384.1_Missense_Mutation_p.E510K					APC membrane recruitment protein 2																		TGCTCCTTCTCCGGGTGCTTG	0.652000													24	86					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685705	248685705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248685705G>A	ENST00000343414.4	+	1	790	c.758G>A	c.(757-759)gGg>gAg	p.G253E		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTTTCTATGGGACCATCATA	0.438000													14	96					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28120072	28120072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28120072C>T	ENST00000330236.6	+	5	869	c.685C>T	c.(685-687)Ctt>Ttt	p.L229F	ZKSCAN8_ENST00000457389.2_Missense_Mutation_p.L229F	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		GGCTGTGTCCCTTATTCGAGA	0.453000													36	147					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54556509	54556509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54556509G>A	ENST00000545554.1	+	8	3592	c.3592G>A	c.(3592-3594)Gaa>Aaa	p.E1198K	UNC13C_ENST00000537900.1_Missense_Mutation_p.E1196K|UNC13C_ENST00000260323.11_Missense_Mutation_p.E1198K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1198					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GATTTCTAAAGAAGATTTTGT	0.373000													6	10					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28877480	28877480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28877480C>T	ENST00000282397.4	-	30	4092	c.3841G>A	c.(3841-3843)Gag>Aag	p.E1281K	FLT1_ENST00000540678.1_Missense_Mutation_p.E499K|FLT1_ENST00000543394.1_Missense_Mutation_p.E304K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1281					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGCCCCGACTCCTTACTTTTA	0.443000													18	39					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1243834	1243834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1243834G>A	ENST00000324642.3	+	9	1419	c.1296G>A	c.(1294-1296)gtG>gtA	p.V432V	SLC6A18_ENST00000296821.4_Intron	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	432					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.V434fs*11(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TGCTGGACGTGGGGGTCCTGC	0.652000													8	52					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19713778	19713778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:19713778G>A	ENST00000284885.3	-	13	1549	c.1516C>T	c.(1516-1518)Ctt>Ttt	p.L506F		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	506					proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity	p.L506I(1)		NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TCTGGATAAAGACTCCCATTG	0.383000													37	101					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155408848	155408848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155408848G>A	ENST00000368346.3	-	5	5737	c.5098C>T	c.(5098-5100)Ccc>Tcc	p.P1700S	ASH1L_ENST00000392403.3_Missense_Mutation_p.P1700S			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1700	Ser-rich.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTTCGAGAGGGAACTCCGTTT	0.413000													15	58					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38646359	38646359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38646359G>A	ENST00000413689.1	-	11	1572	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F	SCN5A_ENST00000423572.2_Missense_Mutation_p.S460F|SCN5A_ENST00000425664.1_Missense_Mutation_p.S460F|SCN5A_ENST00000455624.2_Missense_Mutation_p.S460F|SCN5A_ENST00000450102.2_Missense_Mutation_p.S460F|SCN5A_ENST00000449557.2_Missense_Mutation_p.S460F|SCN5A_ENST00000414099.2_Missense_Mutation_p.S460F|SCN5A_ENST00000451551.2_Missense_Mutation_p.S460F|SCN5A_ENST00000333535.4_Missense_Mutation_p.S460F|SCN5A_ENST00000443581.1_Missense_Mutation_p.S460F	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	460					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CATCTCCAAGGAGCTACGGGA	0.547000													9	22					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10104320	10104320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10104320C>T	ENST00000264828.3	-	18	1755	c.1670G>A	c.(1669-1671)gGg>gAg	p.G557E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	557	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			ACCAGGCAGCCCAGGGAGGCC	0.592000													18	58					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9943555	9943555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9943555C>T	ENST00000506583.1	-	8	926	c.709G>A	c.(709-711)Gag>Aag	p.E237K	SLC2A9_ENST00000264784.3_Missense_Mutation_p.E266K|SLC2A9_ENST00000309065.3_Missense_Mutation_p.E237K			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	266					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						GCTCTTGCCTCGTTGTGCTTC	0.582000													16	28					0	0	1	0	0
BSPRY	54836	broad.mit.edu	37	9	116132056	116132056	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116132056C>T	ENST00000374183.4	+	6	882	c.843C>T	c.(841-843)ttC>ttT	p.F281F	BSPRY_ENST00000462085.1_3'UTR	NM_017688.2	NP_060158.2	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	281	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						CCACCTCCTTCCAGAATGGGC	0.597000													22	45					0	0	1	0	0
RBMX2	51634	broad.mit.edu	37	X	129546525	129546525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:129546525C>T	ENST00000305536.6	+	6	736	c.672C>T	c.(670-672)ctC>ctT	p.L224L		NM_016024.2	NP_057108.2	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	224	Lys-rich.						nucleotide binding|RNA binding			breast(4)|endometrium(2)|large_intestine(1)|liver(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	19						GGCAGAAGCTCCCCAAATCCA	0.557000													37	14					0	0	1	0	0
DCAF5	8816	broad.mit.edu	37	14	69558597	69558597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:69558597G>A	ENST00000341516.5	-	6	820	c.673C>T	c.(673-675)Ctg>Ttg	p.L225L	DCAF5_ENST00000557386.1_Silent_p.L224L|DCAF5_ENST00000556847.1_Silent_p.L143L|DCAF5_ENST00000554215.1_Silent_p.L143L|DCAF5_ENST00000553293.1_5'UTR|DCAF5_ENST00000389997.6_Silent_p.L225L	NM_003861.2	NP_003852.1	Q96JK2	DCAF5_HUMAN	DDB1 and CUL4 associated factor 5	225						CUL4 RING ubiquitin ligase complex				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|upper_aerodigestive_tract(2)	29						CCATAGCGCAGGAGAGAACTG	0.542000													6	19					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128856489	128856489	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128856489G>A	ENST00000310343.9	-	13	1330	c.1331C>T	c.(1330-1332)tCc>tTc	p.S444F	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.S95F|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.S95F|ARHGAP32_ENST00000524655.1_Missense_Mutation_p.S370F	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	444	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CTTACATAGGGAACCCACAGA	0.468000													23	87					0	0	1	0	0
IFNA14	3448	broad.mit.edu	37	9	21239413	21239413	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21239413G>A	ENST00000380222.2	-	1	565	c.522C>T	c.(520-522)tcC>tcT	p.S174S		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	174					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AAAAAGAGAGGGATCTCATGA	0.388000													99	357					0	0	1	0	0
FUT4	2526	broad.mit.edu	37	11	94277911	94277911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94277911C>T	ENST00000358752.2	+	1	895	c.612C>T	c.(610-612)gcC>gcT	p.A204A		NM_002033.3	NP_002024.1	P22083	FUT4_HUMAN	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	204					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCGATAGCGCCCCGAGGCCGC	0.746000													3	8					0	0	1	0	0
SLC16A3	9123	broad.mit.edu	37	17	80195756	80195756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80195756G>A	ENST00000581287.1	+	3	3432	c.1110G>A	c.(1108-1110)ggG>ggA	p.G370G	SLC16A3_ENST00000392339.1_Silent_p.G370G|SLC16A3_ENST00000392341.1_Silent_p.G370G|SLC16A3_ENST00000582743.1_Silent_p.G370G	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	370					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	TGCTCGTCGGGCCCCCTTCGG	0.701000													14	25					0	0	1	0	0
RHBDL2	54933	broad.mit.edu	37	1	39381281	39381281	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:39381281C>A	ENST00000289248.2	-	3	1356	c.348G>T	c.(346-348)aaG>aaT	p.K116N	RHBDL2_ENST00000540558.1_Missense_Mutation_p.K116N|RHBDL2_ENST00000538156.1_Missense_Mutation_p.K183N|RP5-864K19.4_ENST00000433671.2_RNA|RHBDL2_ENST00000372985.3_Missense_Mutation_p.K196N|RHBDL2_ENST00000372990.1_Missense_Mutation_p.K116N			Q9NX52	RHBL2_HUMAN	rhomboid, veinlet-like 2 (Drosophila)	116					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	8	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CTTCCTCCCTCTTCTCAGGAC	0.453000													21	83					1.22574e-08	1.23e-08	1	1	0
MIPOL1	145282	broad.mit.edu	37	14	37969339	37969339	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:37969339C>T	ENST00000327441.7	+	13	1724	c.1258C>T	c.(1258-1260)Caa>Taa	p.Q420*	MIPOL1_ENST00000537471.1_Nonsense_Mutation_p.Q420*|MIPOL1_ENST00000396294.2_Nonsense_Mutation_p.Q420*|MIPOL1_ENST00000539062.2_Nonsense_Mutation_p.Q389*|MIPOL1_ENST00000545536.1_Nonsense_Mutation_p.Q389*|MIPOL1_ENST00000556451.1_Nonsense_Mutation_p.Q389*|MIPOL1_ENST00000536774.1_Nonsense_Mutation_p.Q239*	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	420										breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		TGAAAAAGTTCAAAAGTAAGT	0.358000													8	39					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47422304	47422304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47422304C>T	ENST00000361866.3	+	32	2353	c.2239C>T	c.(2239-2241)Ccc>Tcc	p.P747S	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	747	C-terminal globular domain.|VWFA 2.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GCTCTGCAGCCCCGGCATCCA	0.701000													4	7					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21329770	21329770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21329770C>T	ENST00000256958.2	+	5	516	c.420C>T	c.(418-420)tcC>tcT	p.S140S		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	140					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CGACCTTATCCACTTGTTTAA	0.289000													23	94					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51516198	51516198	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:51516198C>T	ENST00000328188.1	+	1	917	c.917C>T	c.(916-918)tCa>tTa	p.S306L		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						AAGGACATTTCAGGTGACAAA	0.358000													21	39					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36563655	36563655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36563655C>T	ENST00000397799.1	-	4	1851	c.1627G>A	c.(1627-1629)Ggc>Agc	p.G543S	COL8A2_ENST00000481785.1_Missense_Mutation_p.G478S|COL8A2_ENST00000303143.4_Missense_Mutation_p.G543S			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	543	Nonhelical region (NC1).				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGGTGCAAGCCTGCGATGCCA	0.726000													8	20					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143921	55143921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55143921C>T	ENST00000396331.1	+	7	1025	c.668C>T	c.(667-669)tCt>tTt	p.S223F	LILRB1_ENST00000427581.2_Missense_Mutation_p.S259F|LILRB1_ENST00000434867.2_Missense_Mutation_p.S223F|LILRB1_ENST00000396315.1_Missense_Mutation_p.S223F|LILRB1_ENST00000448689.1_Missense_Mutation_p.S223F|LILRB1_ENST00000418536.2_Missense_Mutation_p.S223F|LILRB1_ENST00000396321.2_Missense_Mutation_p.S223F|LILRB1_ENST00000324602.7_Missense_Mutation_p.S223F|LILRB1_ENST00000396317.1_Missense_Mutation_p.S223F|LILRB1_ENST00000396332.4_Missense_Mutation_p.S223F|LILRB1_ENST00000396327.3_Missense_Mutation_p.S223F	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	223	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCAGGTGTTTCTAAGAAGCCA	0.557000										HNSCC(37;0.09)			34	80					0	0	1	0	0
BMP4	652	broad.mit.edu	37	14	54418878	54418878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:54418878C>T	ENST00000245451.4	-	3	456	c.63G>A	c.(61-63)gcG>gcA	p.A21A	BMP4_ENST00000558984.1_Silent_p.A21A|BMP4_ENST00000417573.1_Silent_p.A21A|BMP4_ENST00000559087.1_Silent_p.A21A	NM_001202.3	NP_001193.2	P12644	BMP4_HUMAN	bone morphogenetic protein 4	21					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(3)|urinary_tract(1)	19						TAGCATGGCTCGCGCCTCCTA	0.567000													23	64					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36093535	36093535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36093535C>T	ENST00000303965.4	-	28	4882	c.4393G>A	c.(4393-4395)Gat>Aat	p.D1465N		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1465	PH 5.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGAAACCCATCTCGTAAAACA	0.328000													23	69					0	0	1	0	0
TMEM214	54867	broad.mit.edu	37	2	27260509	27260509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27260509C>T	ENST00000238788.9	+	9	1153	c.1091C>T	c.(1090-1092)aCc>aTc	p.T364I	TMEM214_ENST00000404032.3_Missense_Mutation_p.T319I	NM_017727.4	NP_060197.4	Q6NUQ4	TM214_HUMAN	transmembrane protein 214	364						integral to membrane	protein binding			kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						ACCCTGCATACCTACTTCCCT	0.577000													49	113					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57828873	57828873	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57828873C>T	ENST00000309668.2	+	1	331	c.204C>T	c.(202-204)tcC>tcT	p.S68S	INHBC_ENST00000550133.1_Silent_p.S68S	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	68					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						GCCCTGTGTCCAGAGCTGCTT	0.572000													11	69					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8492966	8492966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8492966G>A	ENST00000381196.4	-	24	2906	c.2363C>T	c.(2362-2364)tCt>tTt	p.S788F	PTPRD_ENST00000358503.5_Missense_Mutation_p.S766F|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.S788F|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.S788F|PTPRD_ENST00000360074.4_Missense_Mutation_p.S775F|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000355233.5_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	788	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTGGAGCCCAGAAATGATCAT	0.493000										TSP Lung(15;0.13)			8	77					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468488	56468488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56468488C>T	ENST00000312153.1	+	1	625	c.625C>T	c.(625-627)Ccc>Tcc	p.P209S		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						TGTCATCTGCCCCGCAGTGCT	0.527000													13	215					0	0	1	0	0
FMO4	2329	broad.mit.edu	37	1	171310668	171310668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171310668G>A	ENST00000367749.3	+	10	1697	c.1367G>A	c.(1366-1368)aGa>aAa	p.R456K		NM_002022.1	NP_002013.1	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	456					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AAGGATCCCAGACTAGCTTGG	0.498000													12	75					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20226810	20226810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20226810C>T	ENST00000245957.5	+	19	2186	c.2110C>T	c.(2110-2112)Cca>Tca	p.P704S	C20orf26_ENST00000377293.1_Missense_Mutation_p.P60S|C20orf26_ENST00000389656.3_Missense_Mutation_p.P60S|C20orf26_ENST00000377309.2_Missense_Mutation_p.P60S	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	704										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TCATGGACTCCCAGGAAAAAA	0.348000													16	73					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587447	36587447	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36587447C>T	ENST00000332987.1	-	7	1142	c.720G>A	c.(718-720)gcG>gcA	p.A240A	APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000352371.1_Silent_p.A243A|APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000404685.3_3'UTR			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	244					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						GGACATCATTCGCAATCATTT	0.438000													23	37					0	0	1	0	0
DROSHA	29102	broad.mit.edu	37	5	31466345	31466345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31466345G>A	ENST00000511367.2	-	18	2654	c.2410C>T	c.(2410-2412)Cta>Tta	p.L804L	DROSHA_ENST00000344624.3_Silent_p.L804L|DROSHA_ENST00000442743.1_Silent_p.L767L|DROSHA_ENST00000513349.1_Silent_p.L767L	NM_013235.4	NP_037367.3	Q9NRR4	RNC_HUMAN	drosha, ribonuclease type III	804	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(19)|lung(33)|ovary(2)|skin(1)	66						CTATTTGCTAGGAGGTGGCGA	0.428000													19	89					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124594501	124594501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124594501C>T	ENST00000368904.1	-	9	2052	c.1103G>A	c.(1102-1104)gGa>gAa	p.G368E	CUZD1_ENST00000545804.1_Missense_Mutation_p.G368E|CUZD1_ENST00000392790.1_Missense_Mutation_p.G368E			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	368	ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		AGAATTATGTCCCATTTCACA	0.358000													19	70					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	51053097	51053097	+	Missense_Mutation	SNP	G	G	A	rs78088324		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:51053097G>A	ENST00000442544.2	+	28	4838	c.4222G>A	c.(4222-4224)Gag>Aag	p.E1408K	RP11-671P2.1_ENST00000582064.1_RNA|DCC_ENST00000581580.1_Missense_Mutation_p.E1041K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1408					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGTGTCTGAGGAGAGCCACAA	0.483000													8	88					0	0	1	0	0
CHST9	83539	broad.mit.edu	37	18	24628466	24628466	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:24628466C>T	ENST00000284224.8	-	3	400	c.121_splice	c.e3-1	p.G41_splice	CHST9_ENST00000580774.1_Splice_Site_p.G41_splice|CHST9_ENST00000581714.1_Splice_Site_p.G41_splice|AQP4-AS1_ENST00000578701.1_RNA	NM_031422.5	NP_113610.2	Q7L1S5	CHST9_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9	41					carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|skin(3)	28	all_lung(6;0.0145)|Ovarian(20;0.124)					TCTCCACTCTCCCTGAAATGA	0.358000													18	60					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47605940	47605940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47605940C>T	ENST00000263774.4	+	7	784	c.702C>T	c.(700-702)gaC>gaT	p.D234D	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	234					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	GCAAATTTGACCTGAACAGCC	0.562000													64	93					0	0	1	0	0
LRRC6	23639	broad.mit.edu	37	8	133650208	133650208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133650208G>A	ENST00000519595.1	-	4	500	c.402C>T	c.(400-402)ttC>ttT	p.F134F	LRRC6_ENST00000250173.1_Silent_p.F134F|LRRC6_ENST00000518642.1_Silent_p.F134F|LRRC6_ENST00000520446.1_5'UTR			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	134	LRRCT.					cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTGCTACCACGAACTCCCTAT	0.418000													18	68					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922292	24922292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922292C>T	ENST00000329468.2	+	1	1752	c.1278C>T	c.(1276-1278)atC>atT	p.I426I		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CTTTGCCCATCCCTGACTTGG	0.547000													28	85					0	0	1	0	0
GRAMD4	23151	broad.mit.edu	37	22	47062746	47062746	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:47062746C>T	ENST00000406902.1	+	10	1047	c.834C>T	c.(832-834)atC>atT	p.I278I	GRAMD4_ENST00000361034.3_Silent_p.I278I			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	278					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		AGTGGAGCATCGTGCCCGAAG	0.617000													45	104					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8938378	8938378	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:8938378A>C	ENST00000256707.3	-	10	1134	c.953T>G	c.(952-954)gTg>gGg	p.V318G	KIDINS220_ENST00000473731.1_Missense_Mutation_p.V318G|KIDINS220_ENST00000418530.1_Missense_Mutation_p.V276G|KIDINS220_ENST00000427284.1_Missense_Mutation_p.V318G|KIDINS220_ENST00000319688.5_Missense_Mutation_p.V319G	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	318					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GATATCTCTCACCATTGTTGC	0.328000													24	44					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533858	92533858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92533858G>A	ENST00000298047.6	+	9	7696	c.7679G>A	c.(7678-7680)cGg>cAg	p.R2560Q	FAT3_ENST00000409404.2_Missense_Mutation_p.R2560Q|FAT3_ENST00000525166.1_Missense_Mutation_p.R2410Q			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2560	Cadherin 23.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGCTAGACCGGGAAAACCCT	0.473000										TCGA Ovarian(4;0.039)			11	27					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20556494	20556494	+	Silent	SNP	G	G	A	rs141823499		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20556494G>A	ENST00000329697.6	-	10	1434	c.1266C>T	c.(1264-1266)atC>atT	p.I422I	ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565232.1_Silent_p.I422I|ACSM2B_ENST00000565322.1_Silent_p.I343I|ACSM2B_ENST00000567001.1_Silent_p.I422I	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	422					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						AGCCAGAGAAGATGCCTATAG	0.517000													22	80					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88761443	88761443	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88761443C>T	ENST00000444431.1	+	0	2573				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										CGACAATATTCCTTGATGGCA	0.373000													62	134					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269468	30269468	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:30269468C>T	ENST00000378981.3	+	4	1179	c.858C>T	c.(856-858)ctC>ctT	p.L286L	MAGEB1_ENST00000397550.1_Silent_p.L286L|MAGEB1_ENST00000397548.2_Silent_p.L286L	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	286	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						TGAAAGTCCTCGAGTTTTTGG	0.507000													46	30					0	0	1	0	0
IFT80	57560	broad.mit.edu	37	3	159997081	159997081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159997081G>A	ENST00000326448.7	-	16	2168	c.1736C>T	c.(1735-1737)tCc>tTc	p.S579F	IFT80_ENST00000483465.1_Missense_Mutation_p.S442F|IFT80_ENST00000496589.1_Missense_Mutation_p.S442F|RP11-432B6.3_ENST00000483754.1_Missense_Mutation_p.S750F	NM_020800.2	NP_065851.1	Q9P2H3	IFT80_HUMAN	intraflagellar transport 80 homolog (Chlamydomonas)	579						cilium axoneme|microtubule basal body				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(12)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GTGAACCAGGGAGCCATCAGC	0.358000													26	55					0	0	1	0	0
SPRY1	10252	broad.mit.edu	37	4	124323283	124323283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:124323283C>T	ENST00000394339.2	+	2	877	c.537C>T	c.(535-537)ttC>ttT	p.F179F	SPRY1_ENST00000339241.1_Silent_p.F179F	NM_001258039.1|NM_005841.2	NP_001244968.1|NP_005832.1	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	179					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				NS(1)|large_intestine(4)|lung(2)|ovary(1)|skin(3)	11						AGCACAAGTTCATTTGTGAAC	0.527000													34	71					0	0	1	0	0
ALX3	257	broad.mit.edu	37	1	110612973	110612973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110612973C>T	ENST00000369792.4	-	1	349	c.262G>A	c.(262-264)Gag>Aag	p.E88K		NM_006492.2	NP_006483.2	O95076	ALX3_HUMAN	ALX homeobox 3	88						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6		all_cancers(81;2.35e-05)|all_epithelial(167;7.69e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.015)|all cancers(265;0.0706)|Epithelial(280;0.0758)|Colorectal(144;0.113)|LUSC - Lung squamous cell carcinoma(189;0.135)		GCGGGGCCCTCGTAGAAGTGG	0.731000													4	19					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611619	179611619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179611619G>A	ENST00000360870.5	-	46	15730	c.15508C>T	c.(15508-15510)Ccc>Tcc	p.P5170S	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	7087	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCATTGGGTGTACCAAAT	0.408000													55	111					0	0	1	0	0
METTL21C	196541	broad.mit.edu	37	13	103339317	103339317	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:103339317G>A	ENST00000267273.6	-	3	378	c.373C>T	c.(373-375)Ctt>Ttt	p.L125F		NM_001010977.1	NP_001010977.1	Q5VZV1	MT21C_HUMAN	methyltransferase like 21C	125							methyltransferase activity			breast(1)|large_intestine(3)|lung(2)|skin(1)	7						ATGGAAACAAGGCCTGGTCCG	0.388000													18	64					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3265439	3265439	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3265439A>G	ENST00000520002.1	-	15	2611	c.2056T>C	c.(2056-2058)Ttc>Ctc	p.F686L	CSMD1_ENST00000542608.1_Missense_Mutation_p.F685L|CSMD1_ENST00000539096.1_Missense_Mutation_p.F685L|CSMD1_ENST00000537824.1_Missense_Mutation_p.F685L|CSMD1_ENST00000602723.1_Missense_Mutation_p.F686L|CSMD1_ENST00000400186.3_Missense_Mutation_p.F686L|CSMD1_ENST00000602557.1_Missense_Mutation_p.F686L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	686	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGATGTTGAACCCTCTGCCA	0.448000													4	11					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71317926	71317926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71317926G>A	ENST00000338099.5	-	3	2234	c.1898C>T	c.(1897-1899)tCa>tTa	p.S633L	FTSJD1_ENST00000434935.2_Missense_Mutation_p.S633L			Q8IYT2	FTSJ1_HUMAN		633						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTCCCGCAATGAATGTAGAAG	0.403000													9	94					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23635600	23635600	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23635600G>A	ENST00000316902.7	-	2	1026	c.301C>T	c.(301-303)Ccc>Tcc	p.P101S	SLC7A8_ENST00000469263.1_Missense_Mutation_p.P101S	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	101					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CCAGATTTGGGGATGGTGACC	0.542000													87	186					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124172600	124172600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124172600C>T	ENST00000303372.5	+	7	895	c.767C>T	c.(766-768)tCc>tTc	p.S256F	TCTN2_ENST00000426174.2_Missense_Mutation_p.S255F	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	256					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		ATTTTCAGTTCCCCCAAACAG	0.368000													48	164					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62675662	62675662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62675662G>A	ENST00000498273.1	+	4	1511	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	406	Glu-rich.									breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						GCTggaggaggaggaggaaga	0.547000													19	47					0	0	1	0	0
ULK1	8408	broad.mit.edu	37	12	132400950	132400950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:132400950C>T	ENST00000321867.4	+	20	2237	c.1886C>T	c.(1885-1887)cCc>cTc	p.P629L		NM_003565.2	NP_003556.1	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	629					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TAGGCTGTGCCCTCCTTTGAC	0.692000													18	120					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	817443	817443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:817443C>T	ENST00000566549.1	+	15	1986	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F	MSLN_ENST00000545450.2_Silent_p.F523F|MSLN_ENST00000382862.3_Silent_p.F531F|MSLN_ENST00000563941.1_Silent_p.F523F			Q13421	MSLN_HUMAN	mesothelin	531					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				TGGCCACGTTCATGAAGCTGC	0.697000													32	83					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027304	37027304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37027304C>T	ENST00000358047.3	+	1	873	c.821C>T	c.(820-822)cCt>cTt	p.P274L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	274										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TACCTGGAGCCTCCTGGGACT	0.607000													47	16					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3679786	3679786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3679786G>A	ENST00000294600.2	+	7	1153	c.1069G>A	c.(1069-1071)Gga>Aga	p.G357R		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	357	Glu-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		GGGTGCCTGGGGAGGTGTGAG	0.672000													5	5					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43594369	43594369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43594369G>A	ENST00000395891.1	+	29	5294	c.4689G>A	c.(4687-4689)ggG>ggA	p.G1563G	HECW1_ENST00000453890.1_Silent_p.G1529G	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1563	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.G1542G(1)		NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						AGAAATGGGGGAAAATTACTT	0.527000													4	24					0	0	1	0	0
GNA14	9630	broad.mit.edu	37	9	80144023	80144023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:80144023C>T	ENST00000341700.6	-	2	784	c.271G>A	c.(271-273)Gac>Aac	p.D91N		NM_004297.3	NP_004288.1	O95837	GNA14_HUMAN	guanine nucleotide binding protein (G protein), alpha 14	91					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	24						CTTAGCGTGTCCATCGCTCTG	0.478000													39	185					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596633	179596633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179596633G>A	ENST00000589042.1	-	58	17193	c.16969C>T	c.(16969-16971)Ctg>Ttg	p.L5657L	TTN_ENST00000342992.6_Silent_p.L4413L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.L5340L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5340	Ig-like 37.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTCAGCCAGCAACATGACA	0.403000													28	103					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175360448	175360448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175360448G>A	ENST00000367674.1	-	7	2191	c.1483C>T	c.(1483-1485)Cct>Tct	p.P495S	TNR_ENST00000263525.2_Missense_Mutation_p.P495S	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	495	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GCCGAGGTAGGGGGGCTGCGG	0.557000													31	62					0	0	1	0	0
AMTN	401138	broad.mit.edu	37	4	71389609	71389609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71389609C>T	ENST00000339336.4	+	4	293	c.163C>T	c.(163-165)Cca>Tca	p.P55S	AMTN_ENST00000504451.1_Missense_Mutation_p.P54S	NM_212557.2	NP_997722.1	Q6UX39	AMTN_HUMAN	amelotin	55					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				NS(3)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)|skin(1)	19			Lung(101;0.235)			AAGTCTGATACCATTAACACA	0.388000													52	108					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508298	106508298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:106508298C>T	ENST00000359195.3	+	2	602	c.292C>T	c.(292-294)Ctg>Ttg	p.L98L	PIK3CG_ENST00000496166.1_Silent_p.L98L|PIK3CG_ENST00000440650.2_Silent_p.L98L	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	98					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						TCACTTCCTCCTGCTCTATCA	0.627000													9	30					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167678	140167678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140167678G>A	ENST00000504120.2	+	1	1803	c.1803G>A	c.(1801-1803)tcG>tcA	p.S601S	PCDHA1_ENST00000378133.3_Silent_p.S601S|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCCGACTCGGGCTACAACG	0.667000													45	94					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104032288	104032288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104032288G>A	ENST00000374874.3	+	3	629	c.190G>A	c.(190-192)Gaa>Aaa	p.E64K	LPPR1_ENST00000395056.2_Missense_Mutation_p.E64K	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		64						integral to membrane	catalytic activity										AGGGACAGAGGAAGAAAGCTT	0.463000													4	50					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28997319	28997319	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:28997319C>T	ENST00000322982.3	-	0	615				AC005013.5_ENST00000436594.1_lincRNA			Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GAGGTTGTTCCCCAGGTACAG	0.657000													4	11					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142572875	142572875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142572875C>T	ENST00000359396.3	-	9	1410	c.1165G>A	c.(1165-1167)Gag>Aag	p.E389K		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	389					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					GTCACCAGCTCCCCGACCAGC	0.562000													19	99					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111398053	111398053	+	Silent	SNP	C	C	T	rs146450390		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111398053C>T	ENST00000265162.5	+	1	825	c.483C>T	c.(481-483)ttC>ttT	p.F161F		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	161					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding	p.F161F(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GGAGGTGTTTCGAGTACAAAA	0.627000													54	143					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74644533	74644533	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:74644533G>A	ENST00000541184.1	-	7	1140	c.663C>T	c.(661-663)ctC>ctT	p.L221L	ZDHHC15_ENST00000373361.3_3'UTR|ZDHHC15_ENST00000373367.3_Silent_p.L230L	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	230						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						GGTAACCAAAGAGAATCACAA	0.383000													15	12					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78790148	78790148	+	Missense_Mutation	SNP	G	G	A	rs68105355		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78790148G>A	ENST00000376767.3	+	14	2515	c.2003G>A	c.(2002-2004)gGa>gAa	p.G668E	PCSK5_ENST00000376752.4_Intron|PCSK5_ENST00000545128.1_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						aaatggaatggaatgaaatgg	0.413000													4	11					0	0	1	0	0
TRAV40	28641	broad.mit.edu	37	14	22783078	22783078	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22783078G>A	ENST00000390467.3	+	0	44																											CCCCCTACAGGAGGAACCAGC	0.408000													19	24					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54901636	54901636	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54901636G>A	ENST00000293373.6	+	4	385		c.e4-1		NCKAP1L_ENST00000545638.2_Splice_Site	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like						actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TCCACCCCCAGGATCATGTAT	0.413000													51	163					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52395327	52395327	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52395327C>T	ENST00000420323.2	+	29	5094	c.4833C>T	c.(4831-4833)ctC>ctT	p.L1611L	DNAH1_ENST00000466628.1_3'UTR	NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1611	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTGACCAGCTCGACTTCATGG	0.607000													5	15					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325546	31325546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31325546C>T	ENST00000269197.5	+	12	5734	c.5734C>T	c.(5734-5736)Cat>Tat	p.H1912Y		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1912					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GAACCTATTTCATGTTGACAA	0.527000													30	133					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4935978	4935978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4935978C>T	ENST00000322013.3	-	1	944	c.916G>A	c.(916-918)Gat>Aat	p.D306N	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTCACTCGATCCCGGATCTGT	0.468000													8	33					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35242163	35242163	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:35242163C>T	ENST00000408931.3	-	8	1749	c.1223G>A	c.(1222-1224)gGg>gAg	p.G408E		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	408						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GGGGCCACTCCCTTGCATGGA	0.552000													7	29					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612740	20612740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20612740G>A	ENST00000333629.1	+	1	846	c.846G>A	c.(844-846)atG>atA	p.M282I		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TTCCTTTGATGAACCCTGTTA	0.413000													70	163					0	0	1	0	0
CDHR4	389118	broad.mit.edu	37	3	49836227	49836227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49836227C>T	ENST00000487256.1	-	4	549	c.527G>A	c.(526-528)aGg>aAg	p.R176K	CDHR4_ENST00000343366.4_3'UTR|CDHR4_ENST00000412678.2_Intron			A6H8M9	CDHR4_HUMAN	cadherin-related family member 4	0					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(3)	11						CACCCCCATCCTGTCACCCAC	0.592000													13	24					0	0	1	0	0
SENP6	26054	broad.mit.edu	37	6	76386875	76386875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76386875C>T	ENST00000370014.3	+	14	2370	c.1751C>T	c.(1750-1752)cCc>cTc	p.P584L	SENP6_ENST00000327284.8_Missense_Mutation_p.P577L|SENP6_ENST00000447266.2_Missense_Mutation_p.P584L|SENP6_ENST00000370010.2_Missense_Mutation_p.P577L|SENP6_ENST00000541192.1_Missense_Mutation_p.P180L	NM_001100409.1	NP_001093879.1	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6	584					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				GCGAAAATTCCCTTTGAAGAA	0.343000													9	43					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940437	22940437	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22940437C>T	ENST00000397104.3	-	5	2000	c.2001G>A	c.(1999-2001)gaG>gaA	p.E667E	ZNF99_ENST00000596209.1_Silent_p.E758E					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGCAGGGTTTCTCTGCAGTAT	0.353000													6	86					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24245745	24245745	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:24245745G>A	ENST00000338315.4	+	10	1032	c.1032G>A	c.(1030-1032)ggG>ggA	p.G344G	MFSD2B_ENST00000406420.3_Silent_p.G344G			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	344					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						AGCGCTTTGGGAAGAAGACGT	0.632000													4	18					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57499062	57499062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57499062C>T	ENST00000420954.2	-	8	749	c.714G>A	c.(712-714)acG>acA	p.T238T	DAB1_ENST00000371231.1_Silent_p.T273T|DAB1_ENST00000439789.2_Silent_p.T154T|DAB1_ENST00000371234.4_Intron|DAB1_ENST00000414851.2_Intron|DAB1_ENST00000485760.1_Intron|DAB1_ENST00000371236.2_Intron			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	273					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCCTTACCTTCGTTGCCTCAA	0.413000													66	77					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2317866	2317866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2317866G>A	ENST00000222990.3	-	2	211	c.169C>T	c.(169-171)Ccg>Tcg	p.P57S		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	57					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		TTCCCCTGCGGCATCTGCATT	0.652000													20	45					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967301	41967301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41967301G>A	ENST00000298919.7	+	10	2328	c.1940G>A	c.(1939-1941)cGa>cAa	p.R647Q	PDZRN4_ENST00000402685.2_Missense_Mutation_p.R907Q|PDZRN4_ENST00000539469.2_Missense_Mutation_p.R649Q			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	907							ubiquitin-protein ligase activity|zinc ion binding	p.R649Q(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AGACCCGTGCGAGACCGAATC	0.517000													8	104					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248039742	248039742	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248039742C>T	ENST00000366481.3	+	6	1460	c.1412C>T	c.(1411-1413)tCc>tTc	p.S471F	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	471						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AATTGGGCATCCAGGGATCAT	0.463000													19	53					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164131	139164131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139164131G>A	ENST00000395297.1	-	13	2757	c.2587C>T	c.(2587-2589)Cct>Tct	p.P863S		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	863										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGCCATCAGGAAGACAGTGT	0.478000										HNSCC(54;0.14)			9	85					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102477362	102477362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102477362G>A	ENST00000260228.2	-	6	869	c.857C>T	c.(856-858)cCc>cTc	p.P286L	MMP20_ENST00000544938.1_5'UTR	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	286					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CTTGTGATGGGGGGCATGGGG	0.527000													22	61					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53303045	53303045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53303045G>A	ENST00000438150.2	-	2	2787	c.1894C>T	c.(1894-1896)Cat>Tat	p.H632Y	ZNF28_ENST00000457749.2_Missense_Mutation_p.H685Y|ZNF28_ENST00000414252.2_Missense_Mutation_p.H632Y|ZNF28_ENST00000360272.4_Missense_Mutation_p.H632Y			P17035	ZNF28_HUMAN	zinc finger protein 28	685					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TCTCCAGTATGAACTCTCTGA	0.408000													53	184					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908370	103908370	+	Missense_Mutation	SNP	G	G	A	rs145758335		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103908370G>A	ENST00000302259.3	+	1	1063	c.820G>A	c.(820-822)Gag>Aag	p.E274K	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	274					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GGCTTGTGCCGAGCGATGTAA	0.517000													40	104					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166152571	166152571	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166152571G>A	ENST00000375437.2	+	2	528	c.238G>A	c.(238-240)Gat>Aat	p.D80N	SCN2A_ENST00000375427.2_Missense_Mutation_p.D80N|SCN2A_ENST00000357398.3_Missense_Mutation_p.D80N|SCN2A_ENST00000283256.6_Missense_Mutation_p.D80N	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	80					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GCCCCTGGAGGATCTGGACCC	0.448000													14	64					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237944	56237944	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56237944G>A	ENST00000312240.2	-	1	70	c.30C>T	c.(28-30)ttC>ttT	p.F10F		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					CCAAAAGAATGAACTCTGTCA	0.363000													18	67					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97852938	97852938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97852938C>T	ENST00000420699.2	+	31	2289	c.2045C>T	c.(2044-2046)tCt>tTt	p.S682F	ANKRD36_ENST00000461153.2_Missense_Mutation_p.S682F	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	682										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						TTTTCAGTGTCTTCTCAGAAA	0.323000													12	47					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39068823	39068823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39068823C>T	ENST00000355481.4	+	98	14459	c.14328C>T	c.(14326-14328)ttC>ttT	p.F4776F	RYR1_ENST00000360985.3_Silent_p.F4776F|RYR1_ENST00000359596.3_Silent_p.F4781F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4781					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.F4781F(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCTGGAAGTTCGGGGTCATCT	0.607000													5	34					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71906994	71906994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71906994C>T	ENST00000393679.1	+	5	983	c.547C>T	c.(547-549)Ccc>Tcc	p.P183S	FOLR1_ENST00000312293.4_Missense_Mutation_p.P183S|FOLR1_ENST00000393681.2_Missense_Mutation_p.P183S|FOLR1_ENST00000393676.3_Missense_Mutation_p.P183S|RP11-807H22.7_ENST00000378140.3_RNA			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	183					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						TTTCTACTTCCCCACACCCAC	0.547000													10	113					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105947179	105947179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105947179C>T	ENST00000357060.3	-	14	1874	c.1759G>A	c.(1759-1761)Gag>Aag	p.E587K	WDR96_ENST00000428666.1_Missense_Mutation_p.E588K|WDR96_ENST00000278064.2_Missense_Mutation_p.E518K	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	587										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AGAGCGTGCTCCAACTCATAC	0.403000													29	55					0	0	1	0	0
TIGD3	220359	broad.mit.edu	37	11	65124002	65124002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65124002C>T	ENST00000309880.5	+	2	930	c.723C>T	c.(721-723)atC>atT	p.I241I		NM_145719.2	NP_663771.1	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	241	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(3)|large_intestine(1)|lung(9)|prostate(2)|skin(2)	17						ACCTGGGCATCCCCTGGTTAG	0.657000													35	133					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	132110674	132110674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132110674C>T	ENST00000404460.1	+	7	559	c.505C>T	c.(505-507)Ccc>Tcc	p.P169S	PLEKHB2_ENST00000303908.3_Missense_Mutation_p.P169S			Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	0						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		ATGTTTTTTTCCCAGCGAATC	0.478000													7	27					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8234962	8234962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8234962C>T	ENST00000339754.5	+	1	156	c.78C>T	c.(76-78)gcC>gcT	p.A26A		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	26					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		CGCCCCGGGCCTCCAACCGCG	0.632000													5	23					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51382068	51382068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51382068G>A	ENST00000216392.7	-	11	1721	c.1389C>T	c.(1387-1389)atC>atT	p.I463I	PYGL_ENST00000532462.1_Silent_p.I463I|PYGL_ENST00000544180.2_Silent_p.I429I	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	463					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding	p.I463I(1)		NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TAGTCTTCACGATGTCTGAGT	0.473000													17	200					0	0	1	0	0
FZD6	8323	broad.mit.edu	37	8	104337524	104337524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:104337524G>A	ENST00000358755.4	+	4	1507	c.1190G>A	c.(1189-1191)cGa>cAa	p.R397Q	FZD6_ENST00000522566.1_Missense_Mutation_p.R397Q|FZD6_ENST00000523739.1_Missense_Mutation_p.R365Q|FZD6_ENST00000540287.1_Missense_Mutation_p.R92Q	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	397					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding	p.R397Q(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			AATCATGTTCGACAAGTCATA	0.413000													77	208					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110477348	110477348	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:110477348G>A	ENST00000260283.4	-	10	1185	c.901C>T	c.(901-903)Cga>Tga	p.R301*	ARHGAP20_ENST00000524756.1_Nonsense_Mutation_p.R278*|ARHGAP20_ENST00000528829.1_Nonsense_Mutation_p.R265*|ARHGAP20_ENST00000357139.3_Nonsense_Mutation_p.R275*|ARHGAP20_ENST00000533353.1_Nonsense_Mutation_p.R275*|ARHGAP20_ENST00000527598.1_Nonsense_Mutation_p.R265*	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	301					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TGCATCTCTCGGGGGAGCTGT	0.542000													94	200					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113510953	113510953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113510953G>A	ENST00000505019.1	-	11	3179	c.3054C>T	c.(3052-3054)ttC>ttT	p.F1018F	C4orf21_ENST00000309071.5_Silent_p.F1018F	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	1018										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ATTCTACCATGAAGTCTTCAT	0.383000													27	85					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887907	97887907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97887907C>T	ENST00000356526.2	+	1	364	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						GGCATATGATCGCTATGTAGC	0.378000													27	162					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46755035	46755035	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:46755035C>T	ENST00000394809.4	-	9	2100	c.1985_splice	c.e9+1	p.R662_splice	MYLK3_ENST00000536476.1_Splice_Site_p.R321_splice	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	662	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				ACCCCCTTACCTTCTGGCCAG	0.448000													15	136					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155720365	155720365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155720365C>T	ENST00000510397.1	+	4	1230	c.1051C>T	c.(1051-1053)Cct>Tct	p.P351S	RBM46_ENST00000514866.1_Missense_Mutation_p.P351S|RBM46_ENST00000281722.3_Missense_Mutation_p.P351S	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	351							nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				GCCAACTCTTCCTGCTCGTCT	0.423000													37	73					0	0	1	0	0
RBM38	55544	broad.mit.edu	37	20	55982841	55982841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:55982841C>T	ENST00000356208.5	+	4	834	c.659C>T	c.(658-660)cCc>cTc	p.P220L	RBM38_ENST00000371219.2_Missense_Mutation_p.P139L	NM_017495.5	NP_059965.2	Q9H0Z9	RBM38_HUMAN	RNA binding motif protein 38	220					3'-UTR-mediated mRNA stabilization|cell cycle|cell cycle arrest|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mRNA processing|negative regulation of cell proliferation|regulation of RNA splicing|RNA splicing	cytosol|nucleus	mRNA 3'-UTR binding|mRNA binding|nucleotide binding|RNA binding			large_intestine(3)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Lung NSC(12;0.00242)|all_lung(29;0.00767)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.55e-12)|Epithelial(14;9.49e-09)|all cancers(14;5.01e-08)			GCCGCAGCACCCGCGGGCACC	0.672000													3	3					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115973129	115973129	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115973129G>A	ENST00000251864.2	+	15	2009	c.1856G>A	c.(1855-1857)tGg>tAg	p.W619*	TDRD1_ENST00000369281.2_Nonsense_Mutation_p.W562*|TDRD1_ENST00000369282.1_Nonsense_Mutation_p.W619*|TDRD1_ENST00000369280.1_Nonsense_Mutation_p.W619*|TDRD1_ENST00000422662.1_Nonsense_Mutation_p.W223*	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	619					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TTAGGAATTTGGACTCCAGAA	0.358000													19	93					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13613147	13613147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13613147G>A	ENST00000404922.3	+	2	1411	c.1292G>A	c.(1291-1293)aGa>aAa	p.R431K	FBLN2_ENST00000295760.7_Missense_Mutation_p.R431K|FBLN2_ENST00000535798.1_Missense_Mutation_p.R457K|FBLN2_ENST00000492059.1_Missense_Mutation_p.R431K	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	431	N.|Subdomain NB (Cys-free).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			TCTATCCCCAGAAGTAGCCCT	0.612000													7	15					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134670844	134670844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134670844G>A	ENST00000398015.3	+	3	1125	c.755G>A	c.(754-756)cGa>cAa	p.R252Q	EPHB1_ENST00000488154.1_Intron	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	252	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CCTATTGGGCGATGCACCTGC	0.577000													49	128					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62516686	62516686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62516686G>A	ENST00000371158.2	+	31	4195	c.4081G>A	c.(4081-4083)Gaa>Aaa	p.E1361K	INADL_ENST00000545929.1_Missense_Mutation_p.E34K|INADL_ENST00000543708.1_Missense_Mutation_p.E145K|INADL_ENST00000316485.6_Missense_Mutation_p.E1361K	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1361					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TGGCAGCGTCGAAGTTGGTAT	0.388000													13	36					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135480069	135480069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135480069G>A	ENST00000394143.1	+	20	8505	c.8214G>A	c.(8212-8214)gtG>gtA	p.V2738V	GPR112_ENST00000370652.1_Silent_p.V2738V|GPR112_ENST00000287534.4_Silent_p.V2491V|GPR112_ENST00000394141.1_Silent_p.V2533V|GPR112_ENST00000412101.1_Silent_p.V2533V	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2738					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGGATTCAGTGAATGAACAGA	0.403000													29	57					0	0	1	0	0
KLK7	5650	broad.mit.edu	37	19	51483734	51483734	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51483734G>A	ENST00000391807.1	-	4	332	c.231C>T	c.(229-231)acC>acT	p.T77T	KLK7_ENST00000597707.1_Silent_p.T5T|CTB-147C22.9_ENST00000594512.1_RNA|KLK7_ENST00000595820.1_Silent_p.T77T|KLK7_ENST00000336317.4_5'UTR	NM_139277.2	NP_644806.1	P49862	KLK7_HUMAN	kallikrein-related peptidase 7	77	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(2)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		CCAGGTGCACGGTGTACTCAC	0.582000													9	57					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85710914	85710914	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85710914G>A	ENST00000322366.6	-	22	4041	c.3634C>T	c.(3634-3636)Ctt>Ttt	p.L1212F	WDFY3_ENST00000295888.4_Missense_Mutation_p.L1212F			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1212						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCAATATAAAGGGCTGCAGTA	0.428000													32	91					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45670699	45670699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45670699G>A	ENST00000270172.3	-	10	1386	c.903C>T	c.(901-903)ttC>ttT	p.F301F	DNMT3L_ENST00000418993.1_Silent_p.F301F|AP001059.5_ENST00000442785.1_RNA	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	301					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		GCACCTCCAGGAAGCGAGATG	0.647000													30	92					0	0	1	0	0
GATSL3	652968	broad.mit.edu	37	22	30682303	30682303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30682303G>A	ENST00000407689.3	-	6	821	c.692C>T	c.(691-693)tCc>tTc	p.S231F	RP1-130H16.18_ENST00000447976.1_3'UTR|GATSL3_ENST00000459785.1_Intron|GATSL3_ENST00000404953.3_Intron	NM_001037666.2	NP_001032755.1			GATS protein-like 3											breast(1)|endometrium(1)|lung(1)	3						CTCGATGAGGGAGAAGGCAAA	0.592000													10	49					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35631136	35631136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:35631136G>A	ENST00000353139.5	-	9	1437	c.956C>T	c.(955-957)cCc>cTc	p.P319L	ACACA_ENST00000394406.2_Missense_Mutation_p.P282L|ACACA_ENST00000360679.3_Missense_Mutation_p.P224L|ACACA_ENST00000335166.5_Missense_Mutation_p.P204L	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	282	ATP-grasp.|Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TAGCTCCTGGGGAACATTTAA	0.413000													38	65					0	0	1	0	0
TRAV27	28655	broad.mit.edu	37	14	22616535	22616535	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22616535C>T	ENST00000390457.2	+	0	373																											ACAGTTCTCTCCACATCACTG	0.542000													23	60					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87489305	87489305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87489305G>A	ENST00000327946.7	-	9	1385	c.1300C>T	c.(1300-1302)Ctc>Ttc	p.L434F	GRID1_ENST00000536331.1_Missense_Mutation_p.L5F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	434						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AATCCTTGGAGGCGGCTGCCC	0.517000										Multiple Myeloma(13;0.14)			27	66					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777014	18777014	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18777014C>T	ENST00000380548.4	+	19	3126	c.2787C>T	c.(2785-2787)ttC>ttT	p.F929F		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	929	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TGGCCCCCTTCGGCTATCTCA	0.662000													23	56					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116744716	116744716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:116744716G>A	ENST00000375300.1	-	12	1489	c.1484C>T	c.(1483-1485)cCc>cTc	p.P495L	SIK3_ENST00000434315.2_Missense_Mutation_p.P336L|SIK3_ENST00000375288.1_5'UTR|SIK3_ENST00000542607.1_Missense_Mutation_p.P389L|SIK3_ENST00000292055.4_Missense_Mutation_p.P437L|SIK3_ENST00000446921.2_Missense_Mutation_p.P447L			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	437						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						TGGAGCCTGGGGGTTGACTCC	0.468000													31	100					0	0	1	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010549	24010549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:24010549G>A	ENST00000496398.1	+	4	1009	c.586G>A	c.(586-588)Gag>Aag	p.E196K	RP11-255H23.4_ENST00000599944.1_lincRNA|RP11-255H23.2_ENST00000471224.1_RNA|RPSAP58_ENST00000354585.4_Missense_Mutation_p.E196K																endometrium(1)|kidney(5)|lung(2)|prostate(1)|urinary_tract(1)	10						ACACCCATGGGAGGTCATGCC	0.522000													10	27					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	38997504	38997504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38997504C>T	ENST00000400482.3	-	4	1818	c.1229G>A	c.(1228-1230)aGa>aAa	p.R410K	KCNJ6_ENST00000288309.6_Missense_Mutation_p.R410K	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	410					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	ATCACCATTTCTTTCTGTTTG	0.478000													54	207					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56899349	56899349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56899349G>A	ENST00000438926.2	+	1	231	c.202G>A	c.(202-204)Gag>Aag	p.E68K	SLC12A3_ENST00000262502.5_Missense_Mutation_p.E68K|SLC12A3_ENST00000563236.1_Missense_Mutation_p.E68K|SLC12A3_ENST00000566786.1_Missense_Mutation_p.E68K	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	68			E -> K (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GCCCACATATGAGCACTATGC	0.592000													37	109					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233372723	233372723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233372723C>T	ENST00000258229.8	-	9	2460	c.2226G>A	c.(2224-2226)gaG>gaA	p.E742E	PCNXL2_ENST00000430153.1_Silent_p.E41E	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	742						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TGACCTGCATCTCTCTGAGGA	0.473000													14	52					0	0	1	0	0
DTNA	1837	broad.mit.edu	37	18	32459583	32459583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:32459583C>T	ENST00000283365.9	+	19	2161	c.1810C>T	c.(1810-1812)Ccc>Tcc	p.P604S	DTNA_ENST00000269192.7_Missense_Mutation_p.P370S|DTNA_ENST00000595022.1_Missense_Mutation_p.P601S|DTNA_ENST00000590831.2_Missense_Mutation_p.P87S|DTNA_ENST00000601125.1_Missense_Mutation_p.P283S|DTNA_ENST00000399113.3_Missense_Mutation_p.P661S|DTNA_ENST00000598142.1_Missense_Mutation_p.P604S|DTNA_ENST00000399097.3_Missense_Mutation_p.P309S|DTNA_ENST00000591182.1_Missense_Mutation_p.P309S|DTNA_ENST00000399121.5_Missense_Mutation_p.P608S|DTNA_ENST00000269190.7_Missense_Mutation_p.P662S|DTNA_ENST00000556414.3_Missense_Mutation_p.P313S|DTNA_ENST00000444659.1_Missense_Mutation_p.P661S|DTNA_ENST00000598334.1_Missense_Mutation_p.P601S	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	661					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						GGATCTTGTTCCCTCACCAAC	0.448000													12	49					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21227219	21227219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21227219G>A	ENST00000233242.1	-	28	12136	c.12009C>T	c.(12007-12009)tcC>tcT	p.S4003S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4003					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTACGGCTGGGGAGGCTGCTG	0.502000													17	88					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306412	54306412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54306412G>A	ENST00000545554.1	+	1	1312	c.1312G>A	c.(1312-1314)Gag>Aag	p.E438K	UNC13C_ENST00000537900.1_Missense_Mutation_p.E438K|UNC13C_ENST00000260323.11_Missense_Mutation_p.E438K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	438					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTCTACTCCAGAGCCAAAAAT	0.408000													39	71					0	0	1	0	0
SLC19A2	10560	broad.mit.edu	37	1	169446940	169446940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169446940G>A	ENST00000236137.5	-	2	496	c.260C>T	c.(259-261)cCt>cTt	p.P87L	SLC19A2_ENST00000367804.3_Intron|SLC19A2_ENST00000367802.3_Missense_Mutation_p.P87L	NM_006996.2	NP_008927.1	O60779	S19A2_HUMAN	solute carrier family 19 (thiamine transporter), member 2	87					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.208)					AAGGAACACAGGAAACAGTAG	0.403000													10	21					0	0	1	0	0
WDR75	84128	broad.mit.edu	37	2	190340087	190340087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:190340087G>A	ENST00000314761.4	+	21	2497	c.2437G>A	c.(2437-2439)Gaa>Aaa	p.E813K		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	813						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AAAATCTGAAGAAAAAGAACT	0.368000													9	50					0	0	1	0	0
NUCB2	4925	broad.mit.edu	37	11	17323410	17323410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17323410C>T	ENST00000529010.1	+	5	591	c.372C>T	c.(370-372)tcC>tcT	p.S124S	NUCB2_ENST00000458064.2_Silent_p.S124S|NUCB2_ENST00000323688.6_Silent_p.S124S	NM_005013.2	NP_005004.1	P80303	NUCB2_HUMAN	nucleobindin 2	124						cytosol|ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|plasma membrane	calcium ion binding|DNA binding			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						AGTTGGATTCCCTTCAAGGTA	0.378000													22	64					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87285691	87285691	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:87285691C>A	ENST00000304053.6	+	2	511	c.28C>A	c.(28-30)Ccc>Acc	p.P10T	NTRK2_ENST00000359847.3_Missense_Mutation_p.P10T|NTRK2_ENST00000376213.1_Missense_Mutation_p.P10T|NTRK2_ENST00000395882.1_Missense_Mutation_p.P10T|NTRK2_ENST00000277120.3_Missense_Mutation_p.P10T|NTRK2_ENST00000323115.4_Missense_Mutation_p.P10T|NTRK2_ENST00000376214.1_Missense_Mutation_p.P10T|NTRK2_ENST00000376208.1_Missense_Mutation_p.P10T	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	10					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						GTGGCATGGACCCGCCATGGC	0.677000										TSP Lung(25;0.17)			20	118					2.27731e-05	2.28153e-05	1	1	0
FAM90A1	55138	broad.mit.edu	37	12	8376712	8376712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8376712C>T	ENST00000538603.1	-	5	781	c.223G>A	c.(223-225)Gaa>Aaa	p.E75K	FAM90A1_ENST00000307435.6_Missense_Mutation_p.E75K	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	75							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		CCTTCCTTTTCCCCAAAGTTC	0.547000													27	138					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143388	55143388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55143388G>A	ENST00000396331.1	+	6	718	c.361G>A	c.(361-363)Gcc>Acc	p.A121T	LILRB1_ENST00000427581.2_Missense_Mutation_p.A157T|LILRB1_ENST00000434867.2_Missense_Mutation_p.A121T|LILRB1_ENST00000396315.1_Missense_Mutation_p.A121T|LILRB1_ENST00000448689.1_Missense_Mutation_p.A121T|LILRB1_ENST00000418536.2_Missense_Mutation_p.A121T|LILRB1_ENST00000396321.2_Missense_Mutation_p.A121T|LILRB1_ENST00000324602.7_Missense_Mutation_p.A121T|LILRB1_ENST00000396317.1_Missense_Mutation_p.A121T|LILRB1_ENST00000396332.4_Missense_Mutation_p.A121T|LILRB1_ENST00000396327.3_Missense_Mutation_p.A121T	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	121	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TCTCCTAGGAGCCTACATCAA	0.597000										HNSCC(37;0.09)			9	110					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21235486	21235486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21235486G>A	ENST00000233242.1	-	26	4381	c.4254C>T	c.(4252-4254)ttC>ttT	p.F1418F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1418				F -> S (in Ref. 5; CAA28420).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGATAGTGTGAACGTATTCT	0.348000													28	67					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21178778	21178778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21178778G>A	ENST00000377122.4	-	3	650	c.254C>T	c.(253-255)tCt>tTt	p.S85F	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377119.1_Missense_Mutation_p.S85F	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	85					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CCTTACCTCAGAAATAAAAGC	0.308000													25	58					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580592	140580592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580592C>T	ENST00000354757.3	+	1	1245	c.1245C>T	c.(1243-1245)gcC>gcT	p.A415A	PCDHB11_ENST00000536699.1_Silent_p.A50A	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		415	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGCACAGCCGAGTACAATA	0.493000													30	128					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46627726	46627726	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46627726G>A	ENST00000470495.1	-	2	2713	c.1266C>T	c.(1264-1266)atC>atT	p.I422I	HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000498678.1_Silent_p.I422I|HOXB3_ENST00000476342.1_Silent_p.I422I|HOXB3_ENST00000472863.1_Silent_p.I349I|HOXB3_ENST00000490677.1_Silent_p.I288I|HOXB3_ENST00000311626.4_Silent_p.I422I|HOXB-AS1_ENST00000508688.1_RNA|HOXB3_ENST00000460160.1_Silent_p.I290I|HOXB3_ENST00000489475.1_Silent_p.I349I|HOXB3_ENST00000485909.2_Silent_p.I290I|HOXB-AS1_ENST00000435312.1_RNA|HOXB-AS3_ENST00000465846.2_RNA			P14651	HXB3_HUMAN	homeobox B3	422					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						GCGCTTCTTGGATTCTACCCT	0.617000											OREG0024516	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	44					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7866409	7866409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:7866409G>A	ENST00000378789.3	-	6	967	c.916C>T	c.(916-918)Ctt>Ttt	p.L306F		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	306	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						TTGGCGCCAAGAGCCAGAGCT	0.488000													63	185					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62442615	62442615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:62442615C>T	ENST00000281156.4	-	7	1143	c.865G>A	c.(865-867)Gat>Aat	p.D289N		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding	p.D289N(1)		NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TAGCTGTTATCATAAGTCTCA	0.378000													29	90					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3267076	3267076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3267076C>T	ENST00000520002.1	-	14	2171	c.1616G>A	c.(1615-1617)cGg>cAg	p.R539Q	CSMD1_ENST00000542608.1_Missense_Mutation_p.R538Q|CSMD1_ENST00000539096.1_Missense_Mutation_p.R538Q|CSMD1_ENST00000537824.1_Missense_Mutation_p.R538Q|CSMD1_ENST00000602723.1_Missense_Mutation_p.R539Q|CSMD1_ENST00000400186.3_Missense_Mutation_p.R539Q|CSMD1_ENST00000602557.1_Missense_Mutation_p.R539Q			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	539	Sushi 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTGCCCGTCCGCTTCCCATA	0.493000													3	15					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501704	90501704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90501704C>T	ENST00000325643.5	+	4	2368	c.2302C>T	c.(2302-2304)Cat>Tat	p.H768Y		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCTGCAAATCCATCTGGCCAG	0.552000													18	56					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595640	140595640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140595640G>A	ENST00000341948.4	+	1	2132	c.1945G>A	c.(1945-1947)Gag>Aag	p.E649K		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		649	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACAATGGCGAGCCTCCGCG	0.726000													26	54					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102737049	102737049	+	RNA	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102737049T>C	ENST00000532855.1	-	0	1137							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	GAATTACCTTTAAAAAGAAAA	0.318000													2	8					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135392938	135392938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:135392938C>T	ENST00000354042.4	-	3	978	c.289G>A	c.(289-291)Gct>Act	p.A97T	AC091736.10_ENST00000378428.3_RNA	NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4	97						integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						TCCACGGCAGCCGCCACGCAG	0.612000													37	207					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233270846	233270846	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233270846G>A	ENST00000258229.8	-	21	3984	c.3750C>T	c.(3748-3750)ttC>ttT	p.F1250F	PCNXL2_ENST00000488780.2_Silent_p.F383F|PCNXL2_ENST00000520463.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1250						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGATGACAGTGAAGCTCAAGT	0.393000													32	58					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15646284	15646284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15646284C>T	ENST00000378076.3	-	20	2394	c.2041G>A	c.(2041-2043)Gaa>Aaa	p.E681K		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	681					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TATGCTCCTTCCCCTTCATTT	0.358000													29	60					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179732833	179732833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179732833C>T	ENST00000420890.2	-	16	2611	c.2494G>A	c.(2494-2496)Gaa>Aaa	p.E832K	CCDC141_ENST00000295723.5_Missense_Mutation_p.E257K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	257							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GCTTGCTTTTCCTGAGAGCAC	0.517000													26	64					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106109697	106109697	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106109697G>A	ENST00000390545.2	-	0	823																											GTCCAGCATGGGAGGTGTGGT	0.587000													72	187					0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161130934	161130934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161130934C>T	ENST00000368002.3	+	3	881	c.504C>T	c.(502-504)acC>acT	p.T168T	USP21_ENST00000368001.1_Silent_p.T168T|USP21_ENST00000289865.8_Silent_p.T168T	NM_001014443.2	NP_001014443.1	Q9UK80	UBP21_HUMAN	ubiquitin specific peptidase 21	168					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GACCCCCTACCCTGTTCAGCA	0.607000													25	65					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28305321	28305321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:28305321G>A	ENST00000284987.5	-	5	1853	c.1732C>T	c.(1732-1734)Cag>Tag	p.Q578*	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	578	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						CGAGAACACTGGCCCCAGGAT	0.483000													9	30					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65489537	65489537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65489537G>A	ENST00000261883.4	-	9	3253	c.3087C>T	c.(3085-3087)ccC>ccT	p.P1029P		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	1029					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						AGCTGCCCTGGGGGATGACCT	0.582000													18	88					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113231680	113231680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113231680C>T	ENST00000369644.1	+	4	1122	c.93C>T	c.(91-93)ttC>ttT	p.F31F	MOV10_ENST00000413052.2_Silent_p.F87F|MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000357443.2_Silent_p.F87F|MOV10_ENST00000369645.1_Silent_p.F87F			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	87					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		ACGTGCGGTTCCCAGAAAAGA	0.498000													20	42					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41151040	41151040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41151040C>T	ENST00000380588.4	+	5	845	c.742C>T	c.(742-744)Cca>Tca	p.P248S	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	248						integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				TATTAATATTCCAGGTGTATT	0.408000													25	112					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40114658	40114658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40114658G>A	ENST00000324616.5	+	13	1718	c.1564G>A	c.(1564-1566)Gaa>Aaa	p.E522K		NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	522										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						CAAAACCAAGGAAAAAATGAA	0.294000													24	88					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17422449	17422449	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17422449C>T	ENST00000375486.4	-	4	429	c.366G>A	c.(364-366)gtG>gtA	p.V122V	PADI2_ENST00000375481.1_Silent_p.V122V|PADI2_ENST00000444885.2_Silent_p.V122V	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	122					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	GGTCTGCGTCCACATCCAGGG	0.602000													50	109					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3256994	3256994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3256994G>A	ENST00000520002.1	-	17	2882	c.2327C>T	c.(2326-2328)cCa>cTa	p.P776L	CSMD1_ENST00000542608.1_Missense_Mutation_p.P775L|CSMD1_ENST00000539096.1_Missense_Mutation_p.P775L|CSMD1_ENST00000537824.1_Missense_Mutation_p.P775L|CSMD1_ENST00000602723.1_Missense_Mutation_p.P776L|CSMD1_ENST00000400186.3_Missense_Mutation_p.P776L|CSMD1_ENST00000602557.1_Missense_Mutation_p.P776L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	776	CUB 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATAATATCCTGGCCATCCAGG	0.388000													19	52					0	0	1	0	0
HCAR3	8843	broad.mit.edu	37	12	123200717	123200717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123200717C>T	ENST00000528880.2	-	1	722	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	HCAR1_ENST00000356987.2_Intron	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	190						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	AACATAGCTTCGTGCCACCGG	0.537000													22	74					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135757541	135757541	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:135757541G>A	ENST00000375845.3	-	4	310	c.280C>T	c.(280-282)Caa>Taa	p.Q94*	MAP3K19_ENST00000392917.3_Nonsense_Mutation_p.Q94*|MAP3K19_ENST00000392918.3_Nonsense_Mutation_p.Q94*|MAP3K19_ENST00000392915.1_Nonsense_Mutation_p.Q111*|MAP3K19_ENST00000375844.3_Nonsense_Mutation_p.Q94*|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000358371.4_Intron	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		CTCATTTCTTGGGGAGGACTG	0.363000													9	104					0	0	1	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622025	234622025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234622025G>A	ENST00000373414.3	+	1	388	c.388G>A	c.(388-390)Gag>Aag	p.E130K	UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A9_ENST00000354728.4_Intron	NM_019078.1	NP_061951.1														cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GTCTTGTGTGGAGCTACTGCA	0.438000													58	221					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23522956	23522956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:23522956G>A	ENST00000296682.3	+	8	1026	c.844G>A	c.(844-846)Gaa>Aaa	p.E282K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	282	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CCGAATTACAGAAGACGAAGA	0.552000										HNSCC(3;0.000094)			30	104					0	0	1	0	0
MYCT1	80177	broad.mit.edu	37	6	153043320	153043320	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:153043320C>T	ENST00000367245.5	+	2	648	c.640C>T	c.(640-642)Cga>Tga	p.R214*	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	214						nucleus				NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TAACAGTCTTCGAGTGGGCCT	0.512000													36	45					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77316575	77316575	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:77316575G>A	ENST00000255194.6	-	25	3108	c.2933C>T	c.(2932-2934)cCt>cTt	p.P978L	AP3B1_ENST00000519295.1_Missense_Mutation_p.P929L|AP3B1_ENST00000523204.1_5'UTR	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	978					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TTCTCCAACAGGTGGCTGAAT	0.338000									Hermansky-Pudlak syndrome				23	61					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42693486	42693486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42693486C>T	ENST00000372999.1	+	7	1017	c.823C>T	c.(823-825)Ctc>Ttc	p.L275F	TOX2_ENST00000435864.2_Missense_Mutation_p.L195F|TOX2_ENST00000423191.1_Missense_Mutation_p.L275F|TOX2_ENST00000358131.5_Intron|TOX2_ENST00000341197.3_Missense_Mutation_p.L317F	NM_032883.2	NP_116272.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCGGGCTAGCCTCGTCTCCAA	0.582000													37	92					0	0	1	0	0
GALR1	2587	broad.mit.edu	37	18	74968155	74968155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74968155G>A	ENST00000299727.3	+	2	708	c.708G>A	c.(706-708)aaG>aaA	p.K236K	GALR1_ENST00000582943.1_3'UTR	NM_001480.3	NP_001471.2	P47211	GALR1_HUMAN	galanin receptor 1	236					digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		ACATGTCAAAGAAGTCTGAAG	0.348000													25	74					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108124267	108124267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108124267G>A	ENST00000273353.3	-	34	4770	c.4714C>T	c.(4714-4716)Cat>Tat	p.H1572Y		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1572						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AGCTGGAAATGAAGAATCTTG	0.318000													8	42					0	0	1	0	0
HAUS4	54930	broad.mit.edu	37	14	23416931	23416931	+	Missense_Mutation	SNP	G	G	A	rs138593865	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23416931G>A	ENST00000206474.7	-	8	970	c.718C>T	c.(718-720)Cgc>Tgc	p.R240C	RP11-298I3.1_ENST00000548819.1_RNA|HAUS4_ENST00000541587.1_Missense_Mutation_p.R240C|RP11-298I3.5_ENST00000555074.1_Missense_Mutation_p.P69L|HAUS4_ENST00000555367.1_Missense_Mutation_p.R195C|HAUS4_ENST00000554446.1_5'UTR|HAUS4_ENST00000397409.4_Missense_Mutation_p.R114C|HAUS4_ENST00000555986.1_Missense_Mutation_p.R195C|HAUS4_ENST00000347758.2_Missense_Mutation_p.R114C|HAUS4_ENST00000342454.8_Missense_Mutation_p.R195C|RP11-298I3.1_ENST00000548322.1_RNA|HAUS4_ENST00000490506.1_Missense_Mutation_p.R116C			Q9H6D7	HAUS4_HUMAN	HAUS augmin-like complex, subunit 4	240					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|cervix(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)	14						GTGAGGCAGCGGAGAAGCACC	0.507000													27	76					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233898898	233898898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233898898G>A	ENST00000233840.3	+	2	274	c.274G>A	c.(274-276)Gac>Aac	p.D92N		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	92							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CCCCTTGTATGACGCGCAGAC	0.617000													56	95					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28841284	28841284	+	Silent	SNP	C	C	T	rs145751891		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28841284C>T	ENST00000336783.4	+	8	1106	c.939C>T	c.(937-939)atC>atT	p.I313I	ATXN2L_ENST00000395547.2_Silent_p.I313I|ATXN2L_ENST00000340394.8_Silent_p.I313I|ATXN2L_ENST00000325215.6_Silent_p.I313I|ATXN2L_ENST00000570200.1_Silent_p.I313I|ATXN2L_ENST00000564304.1_Silent_p.I313I|ATXN2L_ENST00000382686.4_Silent_p.I313I	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	313						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						GCCTACGGATCGCCATGGAGA	0.602000													10	42					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46216600	46216600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46216600C>T	ENST00000371374.1	-	3	450	c.259G>A	c.(259-261)Gac>Aac	p.D87N	RCAN2_ENST00000405162.1_Missense_Mutation_p.D87N|RCAN2_ENST00000330430.6_Missense_Mutation_p.D41N|RCAN2_ENST00000306764.7_Missense_Mutation_p.D87N	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	41					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						GTCACACAGTCATCATAAGTC	0.418000													5	61					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47746586	47746586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47746586G>A	ENST00000273857.4	-	5	631	c.632C>T	c.(631-633)cCc>cTc	p.P211L	CORIN_ENST00000502252.1_Missense_Mutation_p.P144L|CORIN_ENST00000505909.1_Missense_Mutation_p.P211L|CORIN_ENST00000504584.1_Missense_Mutation_p.P211L|CORIN_ENST00000508498.1_Missense_Mutation_p.P72L	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	211	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GGACCTACAGGGCAGGAGTCC	0.413000													48	126					0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5340055	5340055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5340055C>T	ENST00000396872.2	+	10	1373	c.1212C>T	c.(1210-1212)atC>atT	p.I404I	SLC29A4_ENST00000439491.2_3'UTR|SLC29A4_ENST00000297195.4_Silent_p.I404I|SLC29A4_ENST00000406453.3_Silent_p.I390I	NM_001040661.1|NM_153247.2	NP_001035751.1|NP_694979.2	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4	404					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		CTCTGCAGATCCTGGCAGCCC	0.667000													22	52					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166408691	166408691	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:166408691G>A	ENST00000402744.4	+	6	1355	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	359					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GACCTACTGGGAGGATAACAA	0.443000													18	56					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157557700	157557700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157557700C>T	ENST00000271532.1	-	4	652	c.517G>A	c.(517-519)Gag>Aag	p.E173K	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	173	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				ACATCATTCTCGTCTCCATAT	0.318000													13	18					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793279	29793279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29793279G>A	ENST00000269202.6	+	11	1383	c.1336G>A	c.(1336-1338)Gga>Aga	p.G446R	MEP1B_ENST00000581447.1_Missense_Mutation_p.G446R	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	446	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						CAGCCCAAATGGAACTCTGTA	0.408000													13	26					0	0	1	0	0
SDC3	9672	broad.mit.edu	37	1	31350044	31350044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:31350044G>A	ENST00000336798.7	-	1	1543	c.51C>T	c.(49-51)tcC>tcT	p.S17S	SDC3_ENST00000471567.1_Intron|SDC3_ENST00000339394.6_Intron			O75056	SDC3_HUMAN	syndecan 3	349						integral to membrane	cytoskeletal protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGAGCTAGGGAGCTGGGTG	0.577000													3	20					0	0	1	0	0
ABO	28	broad.mit.edu	37	9	136131040	136131040	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136131040C>T	ENST00000453660.2	-	0	1088							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		CTCCCAGAGCCCCTGGCAGCC	0.652000													5	5					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64880832	64880832	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64880832G>A	ENST00000169565.3	+	4	624	c.624G>A	c.(622-624)ctG>ctA	p.L208L	CACNG5_ENST00000533854.1_Intron|CACNG5_ENST00000307139.3_Intron			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	0				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CTGCCCCACTGAGCCGGGGAG	0.582000													11	110					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121976229	121976229	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121976229C>T	ENST00000498619.1	+	3	925	c.487C>T	c.(487-489)Ccc>Tcc	p.P163S	CASR_ENST00000296154.5_Missense_Mutation_p.P163S|CASR_ENST00000490131.1_Missense_Mutation_p.P163S	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	163					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity	p.P163S(1)		NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTTCTACATTCCCCAGGTACT	0.567000													17	69					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63852307	63852307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:63852307C>T	ENST00000279873.7	+	10	3495	c.3085C>T	c.(3085-3087)Cgg>Tgg	p.R1029W	ARID5B_ENST00000309334.5_Missense_Mutation_p.R786W	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1029					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding	p.R1029W(1)		NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					GAAAAAGGCCCGGGCAGTGTC	0.597000													29	112					0	0	1	0	0
MEGF9	1955	broad.mit.edu	37	9	123476144	123476144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123476144G>A	ENST00000373930.3	-	1	604	c.493C>T	c.(493-495)Ccg>Tcg	p.P165S	MEGF9_ENST00000426959.1_Missense_Mutation_p.P157S	NM_001080497.2	NP_001073966.2	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	165	Pro-rich.					integral to membrane	calcium ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	16						GTGGGCGCCGGTACGGTGGTC	0.726000													15	26					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347431	48347431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48347431C>T	ENST00000319856.4	+	1	960	c.939C>T	c.(937-939)acC>acT	p.T313T		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						TCATTTATACCCTGAGAAATG	0.323000													13	59					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6239766	6239766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6239766C>T	ENST00000400104.3	-	9	858	c.658G>A	c.(658-660)Gat>Aat	p.D220N	L3MBTL4_ENST00000535782.1_Missense_Mutation_p.D33N|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.D220N|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.D220N|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.D220N			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	220					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				AGTAAGCGATCTTCAACAATA	0.403000													13	110					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79747293	79747293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:79747293G>A	ENST00000261205.4	+	9	1479	c.822G>A	c.(820-822)ttG>ttA	p.L274L	SYT1_ENST00000393240.3_Silent_p.L274L|SYT1_ENST00000457153.2_Silent_p.L271L|SYT1_ENST00000552744.1_Silent_p.L274L	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	274	Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						AAGAGAAATTGGGTGATATCT	0.373000													63	120					0	0	1	0	0
S100A3	6274	broad.mit.edu	37	1	153520173	153520173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153520173G>A	ENST00000368713.3	-	3	487	c.291C>T	c.(289-291)ccC>ccT	p.P97P	S100A3_ENST00000368712.1_Silent_p.P97P|S100A4_ENST00000368714.1_Intron	NM_002960.1	NP_002951.1	P33764	S10A3_HUMAN	S100 calcium binding protein A3	97							calcium ion binding|protein binding			breast(1)|liver(1)|lung(1)	3	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGAGCAGGGGGGCTCTGAGG	0.622000													17	91					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101844953	101844953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101844953C>T	ENST00000360264.3	+	18	2429	c.2409C>T	c.(2407-2409)ccC>ccT	p.P803P	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000556210.1_Silent_p.P634P|CUX1_ENST00000550008.2_Silent_p.P736P|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292535.7_Silent_p.P792P|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000546411.2_Silent_p.P690P|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000549414.2_Silent_p.P770P	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	792					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						AGGACGCCCCCGGGCTGGACC	0.667000													20	39					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378681	114378681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:114378681C>T	ENST00000312719.5	-	5	1969	c.781G>A	c.(781-783)Gaa>Aaa	p.E261K	HS3ST5_ENST00000411826.1_Missense_Mutation_p.E261K|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	261					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GGCAGAGGTTCCGTGATGAGG	0.433000													22	43					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29194715	29194715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:29194715G>A	ENST00000240100.2	-	4	1402	c.1013C>T	c.(1012-1014)tCc>tTc	p.S338F	DUSP4_ENST00000240101.2_Missense_Mutation_p.S247F	NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	338	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		CGCAGCACAGGACGTGGCCAG	0.662000													9	26					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41323603	41323603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41323603C>T	ENST00000551295.2	+	7	619	c.502C>T	c.(502-504)Ctt>Ttt	p.L168F	CNTN1_ENST00000360099.3_Missense_Mutation_p.L168F|CNTN1_ENST00000547702.1_Missense_Mutation_p.L168F|CNTN1_ENST00000347616.1_Missense_Mutation_p.L168F|CNTN1_ENST00000348761.2_Missense_Mutation_p.L157F|CNTN1_ENST00000547849.1_Missense_Mutation_p.L168F	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	168	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CCTAGATGATCTTAGCTATCG	0.338000													8	49					0	0	1	0	0
VGLL1	51442	broad.mit.edu	37	X	135618348	135618348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135618348G>A	ENST00000370634.3	+	2	339	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	57					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					GAGCCCCCAGGAATTGACCCC	0.537000													36	20					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664162	44664162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44664162G>A	ENST00000454036.1	+	3	412	c.336G>A	c.(334-336)aaG>aaA	p.K112K	SLC12A5_ENST00000539566.1_Silent_p.K89K|SLC12A5_ENST00000372315.1_Silent_p.K89K|SLC12A5_ENST00000243964.3_Silent_p.K89K	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	112					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTGGAAAAAAGAAGCCGGTGC	0.557000													18	42					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67283854	67283854	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67283854G>A	ENST00000392676.3	-	15	2005	c.1941C>T	c.(1939-1941)ccC>ccT	p.P647P	ABCA5_ENST00000392677.2_Silent_p.P647P|ABCA5_ENST00000588877.1_Silent_p.P647P			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	647	ABC transporter 1.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					GTCGAGAACAGGGGTCCATTC	0.413000													45	96					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44415559	44415559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44415559C>T	ENST00000372343.3	+	2	1217	c.555C>T	c.(553-555)taC>taT	p.Y185Y		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	185					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TACCCCAGTACCGCAAAGGCC	0.647000													6	16					0	0	1	0	0
MIR7162	102466227	broad.mit.edu	37	15	62539564	62539564	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:62539564C>T	ENST00000570077.1	-	0	218																											TGCAGATACTCGGCATACTGC	0.542000													13	28					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20329750	20329750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20329750G>A	ENST00000302555.5	-	7	1159	c.1010C>T	c.(1009-1011)tCc>tTc	p.S337F	GP2_ENST00000381360.5_Missense_Mutation_p.S193F|GP2_ENST00000381362.4_Missense_Mutation_p.S340F|GP2_ENST00000341642.5_Missense_Mutation_p.S190F|GP2_ENST00000573897.1_5'UTR			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	340	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GACGTTCAGGGAACTGAGAAA	0.468000													37	95					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467212	10467212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10467212C>T	ENST00000382483.3	-	4	4619	c.4396G>A	c.(4396-4398)Gag>Aag	p.E1466K		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1466					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTCTGCCTCTCGCTGGCACTT	0.657000													40	78					0	0	1	0	0
CLDN3	1365	broad.mit.edu	37	7	73184326	73184326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73184326C>T	ENST00000395145.2	-	1	274	c.54G>A	c.(52-54)ctG>ctA	p.L18L		NM_001306.3	NP_001297.1	O15551	CLD3_HUMAN	claudin 3	18					response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity			kidney(1)|lung(1)	2		Lung NSC(55;0.159)				CGATGGTGCCCAGCCAGCCCA	0.692000													10	18					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136568062	136568062	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136568062G>A	ENST00000371872.4	-	13	1901	c.1644C>T	c.(1642-1644)ttC>ttT	p.F548F	SARDH_ENST00000439388.1_Silent_p.F548F|SARDH_ENST00000371868.1_5'UTR|SARDH_ENST00000422262.2_Silent_p.F380F	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	548					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GCGGGAAGGCGAAGGTGTACT	0.662000													4	14					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135431120	135431120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135431120C>T	ENST00000394143.1	+	6	5546	c.5255C>T	c.(5254-5256)tCa>tTa	p.S1752L	GPR112_ENST00000370652.1_Missense_Mutation_p.S1752L|GPR112_ENST00000287534.4_Missense_Mutation_p.S1689L|GPR112_ENST00000394141.1_Missense_Mutation_p.S1547L|GPR112_ENST00000412101.1_Missense_Mutation_p.S1547L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1752					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AATATGCTTTCACCTACTCAT	0.413000													50	76					0	0	1	0	0
C16orf92	146378	broad.mit.edu	37	16	30035190	30035190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30035190C>T	ENST00000300575.2	+	2	294	c.273C>T	c.(271-273)atC>atT	p.I91I		NM_001109659.1|NM_001109660.1	NP_001103129.1|NP_001103130.1	Q96LL3	CP092_HUMAN	chromosome 16 open reading frame 92	91						integral to membrane				breast(3)|lung(3)	6						AGAAACCCATCGTGTTCATTA	0.557000													5	43					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513721	78513721	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:78513721C>T	ENST00000397909.2	+	15	3918	c.3745C>T	c.(3745-3747)Cga>Tga	p.R1249*	NAV3_ENST00000266692.7_Nonsense_Mutation_p.R1249*|NAV3_ENST00000536525.2_Nonsense_Mutation_p.R1249*|NAV3_ENST00000228327.6_Nonsense_Mutation_p.R1249*			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1249	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACCCACATTTCGAAGGTAAGG	0.403000										HNSCC(70;0.22)			7	54					0	0	1	0	0
CAMKK1	84254	broad.mit.edu	37	17	3772812	3772812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3772812G>A	ENST00000381771.2	-	15	1571	c.1424C>T	c.(1423-1425)tCa>tTa	p.S475L	CAMKK1_ENST00000381769.2_Missense_Mutation_p.S464L|CAMKK1_ENST00000348335.2_Missense_Mutation_p.S437L|CAMKK1_ENST00000158166.5_Missense_Mutation_p.S475L			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	437					synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		GAGCCTGACTGAGTTCTTAAC	0.622000													18	56					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785469	134785469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134785469G>A	ENST00000537858.1	-	2	361	c.161C>T	c.(160-162)tCc>tTc	p.S54F		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	54	FHA.									breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTGACGGCGGGAGAGGCGAGG	0.657000													6	64					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11738216	11738216	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11738216G>A	ENST00000262442.3	+	49	9575		c.e49+1		DNAH9_ENST00000454412.2_Splice_Site	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCTGAACAAGGTAGGAGGACT	0.562000													6	7					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47981665	47981665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47981665C>T	ENST00000318711.7	+	34	4222	c.4039C>T	c.(4039-4041)Cgt>Tgt	p.R1347C	DIP2A_ENST00000417564.2_Missense_Mutation_p.R1346C|DIP2A_ENST00000400274.1_Missense_Mutation_p.R1342C	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	1346					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TTTTAGGGTTCGTTTGGTAGA	0.458000													33	130					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262462	140262462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140262462G>A	ENST00000289272.2	+	1	609	c.609G>A	c.(607-609)gaG>gaA	p.E203E	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.E203E|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACAGAGAGGAAATTCAGG	0.448000													8	98					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95947900	95947900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95947900G>A	ENST00000317620.9	+	14	1787	c.1654G>A	c.(1654-1656)Gaa>Aaa	p.E552K	PROM2_ENST00000317668.4_Missense_Mutation_p.E552K|PROM2_ENST00000542147.1_Missense_Mutation_p.E552K|PROM2_ENST00000403131.2_Missense_Mutation_p.E552K	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	552						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						GCAGTGCAAGGAAGGGGCAGC	0.612000													9	24					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157667561	157667561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157667561G>A	ENST00000368184.3	-	5	738	c.447C>T	c.(445-447)atC>atT	p.I149I	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Silent_p.I149I	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	149	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity	p.I149I(1)		autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AATTCACTGTGATCTTCTCTA	0.338000													51	118					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60184221	60184221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60184221G>A	ENST00000300187.6	+	5	2057	c.1780G>A	c.(1780-1782)Gag>Aag	p.E594K	MS4A14_ENST00000531787.1_Missense_Mutation_p.E482K|MS4A14_ENST00000395005.2_Missense_Mutation_p.E577K|MS4A14_ENST00000531783.1_Missense_Mutation_p.E627K	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	594	Gln-rich.					integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						GACTGATAAGGAGCAAAACTC	0.463000													14	33					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21992264	21992264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21992264C>T	ENST00000327430.3	-	2	1892	c.1598G>A	c.(1597-1599)gGc>gAc	p.G533D	SALL2_ENST00000450879.2_Missense_Mutation_p.G396D|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	533							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GATGGCTGAGCCCTCACTCCC	0.522000													7	66					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420498	55420498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55420498C>T	ENST00000242994.3	+	2	653	c.275C>T	c.(274-276)gCt>gTt	p.A92V		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	92					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						AGAGTCAAGGCTAATGCCAGA	0.502000													22	76					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114380799	114380799	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114380799G>A	ENST00000359785.5	-	13	1358	c.1223C>T	c.(1222-1224)cCt>cTt	p.P408L	PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000525799.1_Missense_Mutation_p.P281L|PTPN22_ENST00000528414.1_Missense_Mutation_p.P353L|PTPN22_ENST00000538253.1_Missense_Mutation_p.P164L|PTPN22_ENST00000420377.2_Missense_Mutation_p.P408L	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	408					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCTGAAGAGGCTCCCCAAC	0.378000													6	99					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11450874	11450874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:11450874C>T	ENST00000423059.3	-	19	4009	c.3758G>A	c.(3757-3759)cGa>cAa	p.R1253Q	AC004538.3_ENST00000445839.1_RNA|AC004160.4_ENST00000425837.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1253	TSP type-1 12.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GCCATCACTTCGAACACAATC	0.403000										HNSCC(18;0.044)			20	48					0	0	1	0	0
C16orf82	162083	broad.mit.edu	37	16	27078298	27078298	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27078298C>T	ENST00000505035.1	+	0	271				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			ATTCAGAGGCCTCCCAGGGCC	0.547000													21	50					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186266028	186266028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186266028C>T	ENST00000445192.2	+	2	66	c.21C>T	c.(19-21)ccC>ccT	p.P7P	PRG4_ENST00000367483.4_Silent_p.P7P|PRG4_ENST00000367484.3_Silent_p.P7P|PRG4_ENST00000367485.4_Silent_p.P7P|PRG4_ENST00000367486.3_Silent_p.P7P	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	7					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						AAACACTTCCCATTTACCTGT	0.373000													21	44					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49168441	49168441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49168441C>T	ENST00000340334.7	-	20	2443	c.2075G>A	c.(2074-2076)gGa>gAa	p.G692E	FOLH1_ENST00000343844.4_Missense_Mutation_p.G399E|FOLH1_ENST00000356696.3_Missense_Mutation_p.G676E|FOLH1_ENST00000533034.1_Missense_Mutation_p.G661E|FOLH1_ENST00000256999.2_Missense_Mutation_p.G707E	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	707					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ATCATAAATTCCTGGGAATGA	0.443000													44	62					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88429746	88429746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:88429746G>A	ENST00000261304.2	-	10	1249	c.1143C>T	c.(1141-1143)acC>acT	p.T381T	GALC_ENST00000393568.4_Silent_p.T358T|GALC_ENST00000393569.2_Silent_p.T355T|GALC_ENST00000544807.2_Silent_p.T325T	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	381					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CAATGATGATGGTGAGGTTCC	0.368000													32	101					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162729659	162729659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:162729659C>T	ENST00000367922.2	+	9	1183	c.745C>T	c.(745-747)Cac>Tac	p.H249Y	DDR2_ENST00000367921.3_Missense_Mutation_p.H249Y	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	249					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CCATGAATACCACGTGTGGCC	0.532000													17	77					0	0	1	0	0
MIR99AHG	388815	broad.mit.edu	37	21	17912223	17912223	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:17912223C>T	ENST00000458468.1	+	0	579				MIRLET7C_ENST00000362160.1_RNA	NR_027790.1																						TTCTAGCTTTCCTTGGAGCAC	0.438000													15	70					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76556101	76556101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:76556101C>T	ENST00000307431.8	+	18	3084	c.2699C>T	c.(2698-2700)cCc>cTc	p.P900L	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.P852L|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.P904L|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.P828L	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	901	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AAGACACAGCCCGCCCCCGCT	0.493000													8	75					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41564759	41564759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41564759C>T	ENST00000263253.7	+	25	5279	c.4060C>T	c.(4060-4062)Cca>Tca	p.P1354S		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1354					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						AGAATCCTTTCCATACCGAAC	0.458000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				21	87					0	0	1	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24524132	24524132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:24524132C>T	ENST00000376862.3	+	2	1032	c.399C>T	c.(397-399)ttC>ttT	p.F133F		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	133					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						ATGGGAAGTTCATTGACCTCT	0.587000													51	117					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21739650	21739650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21739650C>T	ENST00000388958.3	+	19	2106	c.2105C>T	c.(2104-2106)tCc>tTc	p.S702F	OTOA_ENST00000388957.3_Missense_Mutation_p.S378F|OTOA_ENST00000388956.4_Missense_Mutation_p.S623F|OTOA_ENST00000286149.4_Missense_Mutation_p.S716F	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	716					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		AGGGGGATCTCCCCCAGGGCT	0.577000													18	54					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427572	135427572	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135427572G>A	ENST00000394143.1	+	6	1998	c.1707G>A	c.(1705-1707)gaG>gaA	p.E569E	GPR112_ENST00000370652.1_Silent_p.E569E|GPR112_ENST00000287534.4_Silent_p.E506E|GPR112_ENST00000394141.1_Silent_p.E364E|GPR112_ENST00000412101.1_Silent_p.E364E	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	569					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTGGGACTGAGAGTGTACAGA	0.428000													29	36					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181620505	181620505	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181620505G>A	ENST00000526775.1	+	7	1148	c.983G>A	c.(982-984)tGg>tAg	p.W328*	CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000358338.5_Nonsense_Mutation_p.W279*|CACNA1E_ENST00000367570.1_Nonsense_Mutation_p.W328*|CACNA1E_ENST00000360108.3_Nonsense_Mutation_p.W328*|CACNA1E_ENST00000367573.2_Nonsense_Mutation_p.W328*|CACNA1E_ENST00000357570.5_Nonsense_Mutation_p.W279*	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	328					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.W328L(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ACCTGGAATTGGCTGTACTTC	0.428000													28	84					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152423746	152423746	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152423746C>T	ENST00000427231.2	-	114	18294	c.18092G>A	c.(18091-18093)tGg>tAg	p.W6031*	NEB_ENST00000409198.1_Nonsense_Mutation_p.W4330*|NEB_ENST00000397345.3_Nonsense_Mutation_p.W6031*|NEB_ENST00000604864.1_Nonsense_Mutation_p.W6031*|NEB_ENST00000172853.10_Nonsense_Mutation_p.W4330*|NEB_ENST00000603639.1_Nonsense_Mutation_p.W6031*	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	6028					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATGACACATCCATTGGTGCAA	0.428000													36	88					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1906950	1906950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1906950G>A	ENST00000399161.2	-	14	2681	c.1934C>T	c.(1933-1935)tCg>tTg	p.S645L	MYT1L_ENST00000428368.2_Missense_Mutation_p.S643L	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	645					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GTATTCAAACGAGGTCTTGGA	0.483000													27	59					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160802361	160802361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160802361C>T	ENST00000368034.4	-	8	1142	c.965G>A	c.(964-966)gGa>gAa	p.G322E	CD244_ENST00000481677.1_5'UTR|CD244_ENST00000322302.7_Missense_Mutation_p.G230E|CD244_ENST00000368033.3_Missense_Mutation_p.G327E	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	327					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTTCCTGGATCCAGACTAGAA	0.458000													24	57					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455093	84455093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:84455093G>A	ENST00000377084.2	-	1	1435	c.550C>T	c.(550-552)Ctc>Ttc	p.L184F		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	184						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TTACCCCGGAGGTCGAGGTGG	0.532000													33	70					0	0	1	0	0
C19orf59	199675	broad.mit.edu	37	19	7742573	7742573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7742573G>A	ENST00000333598.3	+	2	599	c.145G>A	c.(145-147)Gac>Aac	p.D49N	C19orf59_ENST00000597445.1_Intron	NM_174918.2	NP_777578.2	Q8IX19	MCEM1_HUMAN	chromosome 19 open reading frame 59	49						integral to membrane				endometrium(1)|lung(2)|skin(1)|stomach(1)	5						CAAAAATCAGGACCATGCAAA	0.567000											OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	49					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44669131	44669131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44669131G>A	ENST00000454036.1	+	7	877	c.801G>A	c.(799-801)gtG>gtA	p.V267V	SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000372315.1_Silent_p.V244V|SLC12A5_ENST00000243964.3_Silent_p.V244V	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	267					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGGCCACTGTGGTGTTTGTGG	0.537000													23	44					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42236191	42236191	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42236191G>A	ENST00000541110.1	-	5	1706	c.1138C>T	c.(1138-1140)Cag>Tag	p.Q380*	TRERF1_ENST00000354325.2_Nonsense_Mutation_p.Q380*|TRERF1_ENST00000340840.2_Nonsense_Mutation_p.Q380*|TRERF1_ENST00000372917.4_Nonsense_Mutation_p.Q380*|TRERF1_ENST00000372922.4_Nonsense_Mutation_p.Q380*			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	380	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGGGGCTCCTGGTAGTAGTAC	0.597000													28	105					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488791	20488791	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20488791C>T	ENST00000555186.1	+	0	274					NR_038836.1																						AGAGACCTCTCTCATGAGAAC	0.413000													21	113					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26697485	26697485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26697485C>T	ENST00000272371.2	-	26	3310	c.3184G>A	c.(3184-3186)Gag>Aag	p.E1062K	OTOF_ENST00000402415.3_Missense_Mutation_p.E372K|OTOF_ENST00000338581.6_Missense_Mutation_p.E315K|OTOF_ENST00000339598.3_Missense_Mutation_p.E315K|OTOF_ENST00000403946.3_Missense_Mutation_p.E1062K	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1062					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGTACGCCTCGTCTGCCATC	0.612000													15	40					0	0	1	0	0
FGF6	2251	broad.mit.edu	37	12	4553315	4553315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4553315C>T	ENST00000228837.2	-	2	477	c.434G>A	c.(433-435)gGa>gAa	p.G145E		NM_020996.1	NP_066276.2	P10767	FGF6_HUMAN	fibroblast growth factor 6	145					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			GTACAATCTTCCTTTACTGTT	0.488000													17	38					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298450	107298450	+	Silent	SNP	G	G	A	rs138480673	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107298450G>A	ENST00000374781.2	-	1	687	c.645C>T	c.(643-645)ctC>ctT	p.L215L		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						AGGCCAGCTTGAGGACAGCTA	0.388000													33	119					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24185163	24185163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:24185163C>T	ENST00000396671.2	-	8	915	c.567G>A	c.(565-567)agG>agA	p.R189R	THRB_ENST00000416420.1_Silent_p.R189R|THRB_ENST00000280696.5_Silent_p.R204R|THRB_ENST00000356447.4_Silent_p.R189R	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	189					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	CTATCAGCTTCCTCTTGGCCA	0.562000													25	66					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158644199	158644199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158644199C>T	ENST00000368148.3	-	10	1450	c.1270G>A	c.(1270-1272)Gac>Aac	p.D424N	SPTA1_ENST00000368147.3_Missense_Mutation_p.D424N	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	424					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGAAATCGGTCATCGTAAGAG	0.448000													72	170					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7909971	7909971	+	Silent	SNP	G	G	A	rs56056557		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7909971G>A	ENST00000254854.4	+	4	1467	c.1317G>A	c.(1315-1317)ggG>ggA	p.G439G		NM_000180.3	NP_000171.1	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	439					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TCCCGCGTGGGGGATCAGCAC	0.652000													3	12					0	0	1	0	0
ABHD15	116236	broad.mit.edu	37	17	27889807	27889807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:27889807G>A	ENST00000307201.4	-	2	1349	c.1179C>T	c.(1177-1179)ggC>ggT	p.G393G	RP11-68I3.2_ENST00000581474.1_RNA	NM_198147.2	NP_937790.2	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15	393						extracellular region	carboxylesterase activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	10						GGCGCAGGAAGCCACAGTGGC	0.592000													28	34					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729931	18729931	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18729931C>T	ENST00000440756.2	-	3	545	c.443G>A	c.(442-444)gGa>gAa	p.G148E	PSD3_ENST00000327040.8_Missense_Mutation_p.G148E|PSD3_ENST00000523619.1_Missense_Mutation_p.G83E			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	148					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTGTAATGTTCCGGAAATGAT	0.453000													21	154					0	0	1	0	0
HINFP	25988	broad.mit.edu	37	11	119003883	119003883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119003883C>T	ENST00000350777.2	+	9	1156	c.1093C>T	c.(1093-1095)Cgc>Tgc	p.R365C	HINFP_ENST00000527410.1_Missense_Mutation_p.R365C	NM_001243259.1|NM_015517.4|NM_198971.2	NP_001230188.1|NP_056332.2|NP_945322.1	Q9BQA5	HINFP_HUMAN	histone H4 transcription factor	365					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						CGTGCACCTTCGCAAGAAGCA	0.502000													42	139					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53241751	53241751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53241751C>T	ENST00000359499.4	-	2	220	c.209G>A	c.(208-210)cGa>cAa	p.R70Q	KRT78_ENST00000304620.4_Missense_Mutation_p.R180Q			Q8N1N4	K2C78_HUMAN	keratin 78	180	Gly-rich.|Head.					keratin filament	protein binding|structural molecule activity	p.R180L(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						CAGAGCCCCTCGTTCTCCCTG	0.607000													8	58					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819304	43819304	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43819304G>A	ENST00000382031.1	+	5	6378	c.6347G>A	c.(6346-6348)tGg>tAg	p.W2116*	MAP1A_ENST00000300231.5_Nonsense_Mutation_p.W1878*|MAP1A_ENST00000399453.1_Nonsense_Mutation_p.W1878*			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1878						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCCTTCTCTTGGGGCACAGCC	0.657000													13	34					0	0	1	0	0
CPPED1	55313	broad.mit.edu	37	16	12798716	12798716	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:12798716G>A	ENST00000381774.4	-	3	720	c.480C>T	c.(478-480)ttC>ttT	p.F160F	CPPED1_ENST00000433677.2_Intron|CPPED1_ENST00000261660.4_Intron	NM_018340.2	NP_060810.2	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain containing 1	160							hydrolase activity|metal ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						TGAGGACCAGGAACAGGACGC	0.617000													14	43					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35779419	35779419	+	Missense_Mutation	SNP	G	G	A	rs77036027	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35779419G>A	ENST00000440995.2	+	30	4403	c.4403G>A	c.(4402-4404)cGa>cAa	p.R1468Q	SPEF2_ENST00000303129.4_5'UTR|SPEF2_ENST00000356031.3_Missense_Mutation_p.R1473Q|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1473					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GACAGTCTTCGAGATCAGTTC	0.398000													11	83					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39159484	39159484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39159484C>T	ENST00000359534.3	-	5	1020	c.682G>A	c.(682-684)Gag>Aag	p.E228K		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	228					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						ATCCAGAGCTCCACGAAGTAG	0.577000													98	57					0	0	1	0	0
DYRK1A	1859	broad.mit.edu	37	21	38877616	38877616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38877616C>T	ENST00000339659.3	+	9	2713	c.1243C>T	c.(1243-1245)Cat>Tat	p.H415Y	DYRK1A_ENST00000398956.2_Missense_Mutation_p.H424Y|DYRK1A_ENST00000338785.3_Missense_Mutation_p.H424Y|DYRK1A_ENST00000455387.2_Missense_Mutation_p.H196Y|DYRK1A_ENST00000398960.2_Missense_Mutation_p.H424Y|DYRK1A_ENST00000451934.1_Missense_Mutation_p.H424Y|DYRK1A_ENST00000321219.8_Missense_Mutation_p.H424Y	NM_130436.2	NP_569120.1	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	424	Protein kinase.		Y -> F.		nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			breast(4)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						CCGTAAACTTCATAACATTCT	0.438000													36	55					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43327114	43327114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43327114G>A	ENST00000380486.3	-	10	1546	c.1305C>T	c.(1303-1305)tcC>tcT	p.S435S	C2CD2_ENST00000329623.7_Silent_p.S280S	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	435						cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						AGCTCAGCGGGGACGCCCTCC	0.582000													10	59					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685370	100685370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100685370C>T	ENST00000306151.4	+	3	10737	c.10673C>T	c.(10672-10674)cCa>cTa	p.P3558L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3558	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGTTCATCTCCAGCAACTCTT	0.478000													45	399					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106543539	106543539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:106543539G>A	ENST00000369096.4	+	3	575	c.341G>A	c.(340-342)gGa>gAa	p.G114E	PRDM1_ENST00000369091.2_Missense_Mutation_p.G78E	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	114	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACACGTTTTGGACCCCTAATA	0.368000			"""D, N, Mis, F, S"""		DLBCL								34	31					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238722307	238722307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238722307G>A	ENST00000316997.4	+	2	190	c.58G>A	c.(58-60)Gga>Aga	p.G20R	RBM44_ENST00000409864.1_Missense_Mutation_p.G20R|RBM44_ENST00000444524.2_3'UTR	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	19							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		CCACAGTAATGGAGGCAACCT	0.423000													16	47					0	0	1	0	0
AMN1	196394	broad.mit.edu	37	12	31850770	31850770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:31850770G>A	ENST00000281471.6	-	4	603	c.438C>T	c.(436-438)atC>atT	p.I146I	AMN1_ENST00000536761.1_Silent_p.I128I|AMN1_ENST00000537562.1_Silent_p.I128I|AMN1_ENST00000542781.1_5'UTR|AMN1_ENST00000541931.1_5'UTR	NM_001113402.1|NM_001278411.1|NM_001278412.1	NP_001106873.1|NP_001265340.1|NP_001265341.1	Q8IY45	AMN1_HUMAN	antagonist of mitotic exit network 1 homolog (S. cerevisiae)	146										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	7	all_cancers(9;7.41e-12)|all_epithelial(9;1.18e-11)|all_lung(12;1.14e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.162)		OV - Ovarian serous cystadenocarcinoma(6;0.0014)			CACCTAAATCGATGATCTTTA	0.423000													16	108					0	0	1	0	0
STEAP1B	256227	broad.mit.edu	37	7	22533207	22533207	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:22533207G>A	ENST00000404369.4	-	3	748	c.333C>T	c.(331-333)atC>atT	p.I111I	STEAP1B_ENST00000406890.2_Silent_p.I92I	NM_001164460.1	NP_001157932.1	Q6NZ63	STEAL_HUMAN	STEAP family member 1B	92						integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			endometrium(1)|kidney(1)|lung(2)	4						TGATGACCAGGATTGGAATTT	0.393000													19	97					0	0	1	0	0
IL36RN	26525	broad.mit.edu	37	2	113818501	113818501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113818501G>A	ENST00000393200.2	+	3	263	c.102G>A	c.(100-102)ggG>ggA	p.G34G	IL36RN_ENST00000346807.3_Silent_p.G34G	NM_012275.2	NP_036407.1	Q9UBH0	I36RA_HUMAN	interleukin 36 receptor antagonist	34						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						TGCATGCAGGGAAGGTCATTA	0.483000													11	43					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143960599	143960599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143960599C>T	ENST00000292427.4	-	2	276	c.244G>A	c.(244-246)Gac>Aac	p.D82N	CYP11B1_ENST00000377675.3_Missense_Mutation_p.D127N|CYP11B1_ENST00000517471.1_Missense_Mutation_p.D82N	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	82					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CCTCCCAAGTCGTACCTGTGG	0.637000									Familial Hyperaldosteronism type I				31	61					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91444808	91444808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91444808G>A	ENST00000261991.3	-	3	409	c.236C>T	c.(235-237)gCc>gTc	p.A79V	RPS6KA5_ENST00000536315.2_5'UTR|RPS6KA5_ENST00000418736.2_Missense_Mutation_p.A79V	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	79	Protein kinase 1.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		AACTTTCATGGCATACAGCTT	0.363000													21	52					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13762864	13762864	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13762864G>A	ENST00000265104.4	-	60	10352	c.10248C>T	c.(10246-10248)ttC>ttT	p.F3416F	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3416	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTATAGAAAAGAAGGAAGCCA	0.478000									Kartagener syndrome				24	70					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35709163	35709163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35709163G>A	ENST00000440995.2	+	19	2764	c.2764G>A	c.(2764-2766)Gaa>Aaa	p.E922K	SPEF2_ENST00000356031.3_Missense_Mutation_p.E927K|CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000509059.1_Missense_Mutation_p.E922K			Q9C093	SPEF2_HUMAN	sperm flagellar 2	927					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAAAGAGAAGGAAATTCATCA	0.428000													8	99					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111785346	111785346	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111785346G>A	ENST00000261726.6	+	22	3832	c.3678G>A	c.(3676-3678)gaG>gaA	p.E1226E		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1226						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TGCGCCGGGAGATGTTGGTGG	0.652000													36	128					0	0	1	0	0
C8orf4	56892	broad.mit.edu	37	8	40011025	40011025	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:40011025G>A	ENST00000315792.3	+	0	37					NM_020130.4	NP_064515.1	Q9NR00	CH004_HUMAN	chromosome 8 open reading frame 4						apoptosis					breast(1)|large_intestine(1)|ovary(1)	3	Ovarian(28;0.0173)	all_cancers(7;5.34e-21)|all_epithelial(6;1.04e-14)|Lung NSC(58;9.35e-06)|all_lung(54;1.39e-05)|Hepatocellular(245;0.00745)|Breast(189;0.0334)|Colorectal(162;0.0815)|Myeloproliferative disorder(644;0.116)|Esophageal squamous(32;0.141)	LUSC - Lung squamous cell carcinoma(45;0.000149)	KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		AAGCCTGGGAGCTGAATTCCG	0.493000													4	38					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39678528	39678528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39678528C>T	ENST00000265708.4	-	6	609	c.506G>A	c.(505-507)aGc>aAc	p.S169N	ADAM2_ENST00000523181.1_5'UTR|ADAM2_ENST00000347580.4_Missense_Mutation_p.S169N|ADAM2_ENST00000521880.1_Missense_Mutation_p.S169N|ADAM2_ENST00000379853.2_Missense_Mutation_p.S169N	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	169					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TACCTCTACGCTTTGTAATTT	0.294000													31	75					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205273430	205273430	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205273430C>T	ENST00000367157.3	-	7	1161	c.1035G>A	c.(1033-1035)gaG>gaA	p.E345E		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	345					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TGGCCCCATTCTCCAGGAGGG	0.667000													20	27					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34526853	34526853	+	Silent	SNP	C	C	T	rs17347322	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34526853C>T	ENST00000374012.3	+	16	2664	c.2535C>T	c.(2533-2535)cgC>cgT	p.R845R	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	845					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					AGAAGCCCCGCGCCTATTACC	0.632000													4	51					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54777751	54777751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54777751G>A	ENST00000218436.6	-	12	3444	c.3415C>T	c.(3415-3417)Cgc>Tgc	p.R1139C		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1139					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										AAGTAGGTGCGAGTCTGGTCC	0.592000													20	25					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167815251	167815251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167815251G>A	ENST00000367848.1	-	20	2909	c.2412C>T	c.(2410-2412)tcC>tcT	p.S804S	ADCY10_ENST00000545172.1_Silent_p.S743S|ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.S896S			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	896					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TCAGAGACAAGGAACGATAGT	0.453000													11	99					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200957930	200957930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200957930G>A	ENST00000332129.2	-	22	3578	c.3262C>T	c.(3262-3264)Ccc>Tcc	p.P1088S	KIF21B_ENST00000461742.2_Missense_Mutation_p.P1088S|KIF21B_ENST00000360529.5_Missense_Mutation_p.P1088S|KIF21B_ENST00000422435.2_Missense_Mutation_p.P1088S	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1088					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TGCAGCTCGGGGTGAGCTTCA	0.627000													12	30					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64591999	64591999	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64591999G>A	ENST00000342711.5	-	37	4601	c.4602C>T	c.(4600-4602)gtC>gtT	p.V1534V		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1534					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GCCGTTCTGAGACCTGCAGGA	0.577000													9	56					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43034198	43034198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43034198G>A	ENST00000394056.2	+	6	1221	c.726G>A	c.(724-726)gaG>gaA	p.E242E	KLC4_ENST00000453940.2_Silent_p.E165E|KLC4_ENST00000394058.1_Silent_p.E242E|KLC4_ENST00000458460.2_Silent_p.E242E|KLC4_ENST00000347162.5_Silent_p.E242E|KLC4_ENST00000259708.3_Silent_p.E260E|KLC4_ENST00000479388.1_Silent_p.E242E			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	242						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			AGGACCTGGAGCGCACATCAG	0.592000													18	70					0	0	1	0	0
LGALS17A	400696	broad.mit.edu	37	19	40172135	40172135	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40172135G>A	ENST00000412609.1	+	0	124																											CAGGGACACCGATCATCCCTT	0.532000													35	35					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89660999	89660999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89660999C>T	ENST00000355754.6	-	3	441	c.344G>A	c.(343-345)gGc>gAc	p.G115D		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	115						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		ATCGCCCAGGCCCTCGGTGTC	0.512000													32	81					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451240	55451240	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55451240G>A	ENST00000446217.1	-	6	1433	c.1031C>T	c.(1030-1032)cCg>cTg	p.P344L	NLRP7_ENST00000592784.1_Missense_Mutation_p.P316L|NLRP7_ENST00000340844.2_Missense_Mutation_p.P316L|NLRP7_ENST00000588756.1_Missense_Mutation_p.P316L|NLRP7_ENST00000448121.2_Missense_Mutation_p.P316L|NLRP7_ENST00000328092.5_Missense_Mutation_p.P316L|NLRP7_ENST00000590030.1_Missense_Mutation_p.P316L			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	316	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TACGTAGATCGGCTGCTGCGC	0.607000													19	37					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2321209	2321209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2321209C>T	ENST00000381458.5	+	13	2127	c.2064C>T	c.(2062-2064)tcC>tcT	p.S688S		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	688					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	CCATGTTGTCCATCGATGTAG	0.587000													24	75					0	0	1	0	0
SMAD9	4093	broad.mit.edu	37	13	37453613	37453613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:37453613G>A	ENST00000379826.4	-	2	556	c.214C>T	c.(214-216)Ccc>Tcc	p.P72S	SMAD9_ENST00000350148.5_Missense_Mutation_p.P72S|SMAD9_ENST00000483941.1_5'UTR|SMAD9_ENST00000399275.2_Missense_Mutation_p.P72S	NM_001127217.2	NP_001120689.1	O15198	SMAD9_HUMAN	SMAD family member 9	72	MH1.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)	18		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		AGGGAGCGGGGAATCGTGACG	0.627000													14	64					0	0	1	0	0
LINC00303	284573	broad.mit.edu	37	1	204006215	204006215	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204006215G>A	ENST00000367207.3	-	0	805																											agtgtttgctgaatagaGAGG	0.557000													12	27					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39792036	39792036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39792036C>T	ENST00000373272.2	+	9	1213	c.808C>T	c.(808-810)Cgc>Tgc	p.R270C	PLCG1_ENST00000244007.3_Missense_Mutation_p.R270C|PLCG1_ENST00000373271.1_Missense_Mutation_p.R270C	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	270					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				GGCTGTTGATCGCCTCCAGGT	0.602000													22	56					0	0	1	0	0
FAM110C	642273	broad.mit.edu	37	2	45964	45964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:45964C>T	ENST00000327669.4	-	1	421	c.422G>A	c.(421-423)gGa>gAa	p.G141E		NM_001077710.2	NP_001071178.2	Q1W6H9	F110C_HUMAN	family with sequence similarity 110, member C	141						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		GCCCTCGTCTCCCGTCCGGGG	0.736000													4	17					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45009750	45009750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:45009750G>A	ENST00000258787.7	-	10	1357	c.1221C>T	c.(1219-1221)ttC>ttT	p.F407F		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	407	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						AGAACTGCTCGAAACTGGGGG	0.547000													8	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9086464	9086464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9086464G>A	ENST00000397910.4	-	1	5554	c.5351C>T	c.(5350-5352)tCt>tTt	p.S1784F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1784	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTTGCTGAAGACTTGGAGAT	0.468000													25	47					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215910690	215910690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215910690C>T	ENST00000272895.7	-	7	962	c.743G>A	c.(742-744)aGa>aAa	p.R248K		NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	248					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGACAGCATTCTGACTATTTC	0.373000													22	64					0	0	1	0	0
XCL2	6846	broad.mit.edu	37	1	168511246	168511246	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168511246G>A	ENST00000367819.2	-	2	193	c.161C>T	c.(160-162)tCc>tTc	p.S54F		NM_003175.3	NP_003166.1	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2	54					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			large_intestine(1)|lung(6)|ovary(1)	8	all_hematologic(923;0.215)					TGCTCTCAAGGAGCCTTCCGT	0.512000													25	49					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50776819	50776819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50776819G>A	ENST00000216923.4	-	5	955	c.606C>T	c.(604-606)ccC>ccT	p.P202P	ZFP64_ENST00000346617.4_Silent_p.P148P|ZFP64_ENST00000477786.1_5'UTR|ZFP64_ENST00000371515.4_Silent_p.P200P|ZFP64_ENST00000371518.2_Silent_p.P202P|ZFP64_ENST00000361387.2_Silent_p.P202P	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TACACTTGTAGGGCTTCACGC	0.547000													51	104					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921784	78921784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78921784G>A	ENST00000261751.3	-	5	974	c.863C>T	c.(862-864)aCc>aTc	p.T288I	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	288					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						ATCGAGGGAGGTGGGTGGCAC	0.562000													22	71					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176524640	176524640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176524640C>T	ENST00000292408.4	+	18	2617	c.2372C>T	c.(2371-2373)tCc>tTc	p.S791F	FGFR4_ENST00000393648.2_Missense_Mutation_p.S723F|FGFR4_ENST00000393637.1_Missense_Mutation_p.S751F|FGFR4_ENST00000502906.1_Missense_Mutation_p.S791F|FGFR4_ENST00000292410.3_Missense_Mutation_p.S751F	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	791					insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CCATTGGGATCCAGCTCCTTC	0.642000										TSP Lung(9;0.080)			29	62					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422810	26422810	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26422810G>A	ENST00000335473.7	+	43	7120	c.6870G>A	c.(6868-6870)agG>agA	p.R2290R	MYO18B_ENST00000536101.1_Silent_p.R2290R|MYO18B_ENST00000407587.2_Silent_p.R2291R	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2290						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCACACTAAGGAGGGGCAGGG	0.637000													4	20					0	0	1	0	0
TMEM242	729515	broad.mit.edu	37	6	157743827	157743827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:157743827G>A	ENST00000367144.3	-	2	200	c.99C>T	c.(97-99)ttC>ttT	p.F33F				Q9NWH2	CF035_HUMAN	transmembrane protein 242	33						integral to membrane											CGGTACCAAGGAAAATTCCAC	0.373000													53	67					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102220766	102220766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102220766C>T	ENST00000227758.2	+	2	1580	c.181C>T	c.(181-183)Cct>Tct	p.P61S	BIRC2_ENST00000527910.1_3'UTR|BIRC2_ENST00000530675.1_Missense_Mutation_p.P12S|BIRC2_ENST00000532672.1_Missense_Mutation_p.P40S	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	61					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		CGCCGGGGTGCCTGTCTCAGA	0.428000													26	124					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52926959	52926959	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52926959G>A	ENST00000295213.4	+	3	579	c.205G>A	c.(205-207)Gat>Aat	p.D69N	SPATA18_ENST00000506829.1_Intron|SPATA18_ENST00000419395.2_Missense_Mutation_p.D69N	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	69					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AGGACGTAATGATGGTGTGGA	0.458000													9	74					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222294837	222294837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:222294837G>A	ENST00000281821.2	-	15	2572	c.2531C>T	c.(2530-2532)cCc>cTc	p.P844L	EPHA4_ENST00000409938.1_Missense_Mutation_p.P844L|EPHA4_ENST00000409854.1_Missense_Mutation_p.P844L|EPHA4_ENST00000392071.4_Missense_Mutation_p.P793L	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	844	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CATTGGAGGGGGTAACCGATA	0.522000													28	81					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716551	13716551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13716551C>T	ENST00000279593.3	-	13	3830	c.3621G>A	c.(3619-3621)gaG>gaA	p.E1207E		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1207					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGGACCGGTCCTCCCACTCCA	0.637000													30	75					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476430	57476430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57476430G>A	ENST00000371236.2	-	14	1869	c.1606C>T	c.(1606-1608)Cca>Tca	p.P536S	DAB1_ENST00000371231.1_Missense_Mutation_p.P569S|DAB1_ENST00000439789.2_Missense_Mutation_p.P450S|DAB1_ENST00000371234.4_Missense_Mutation_p.P536S|DAB1_ENST00000420954.2_Missense_Mutation_p.P534S|DAB1_ENST00000414851.2_Missense_Mutation_p.P518S|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	569					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TCACCAAATGGATCACTGTTG	0.438000													31	84					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35406890	35406890	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:35406890G>A	ENST00000287272.2	+	2	204	c.184G>A	c.(184-186)Gat>Aat	p.D62N	UNC5D_ENST00000416672.1_Missense_Mutation_p.D62N|UNC5D_ENST00000420357.1_Missense_Mutation_p.D62N|UNC5D_ENST00000404895.2_Missense_Mutation_p.D62N|UNC5D_ENST00000453357.2_Missense_Mutation_p.D57N			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	62	Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GGAGCCAGATGATGCTTATAT	0.483000													13	45					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75042611	75042611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75042611G>A	ENST00000326665.5	-	13	2404	c.2186C>T	c.(2185-2187)tCa>tTa	p.S729L	C1orf173_ENST00000433746.2_Intron	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	729	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TAATGGCAATGAATCCTTTCC	0.388000													13	36					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60069930	60069930	+	Splice_Site	SNP	C	C	T	rs11559108		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:60069930C>T	ENST00000267484.5	-	7	2564	c.2229_splice	c.e7+1	p.Q743_splice	RTN1_ENST00000395090.1_Splice_Site_p.Q160_splice|RTN1_ENST00000557422.1_5'UTR|RTN1_ENST00000342503.4_Splice_Site_p.Q175_splice	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	743	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity	p.Q743H(1)		central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TAGAACTTACCTGGTGCTTAA	0.318000													20	42					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152737851	152737851	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152737851C>T	ENST00000367255.5	-	41	6322	c.5721G>A	c.(5719-5721)aaG>aaA	p.K1907K	SYNE1_ENST00000341594.5_Silent_p.K1944K|SYNE1_ENST00000423061.1_Silent_p.K1914K|SYNE1_ENST00000448038.1_Silent_p.K1914K|SYNE1_ENST00000265368.4_Silent_p.K1907K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1907					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CATTGAGGTCCTTTTCTATCA	0.463000										HNSCC(10;0.0054)			25	30					0	0	1	0	0
LSS	4047	broad.mit.edu	37	21	47636337	47636337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47636337G>A	ENST00000397728.3	-	7	827	c.749C>T	c.(748-750)gCc>gTc	p.A250V	LSS_ENST00000356396.4_Missense_Mutation_p.A250V|LSS_ENST00000457828.2_Missense_Mutation_p.A170V|LSS_ENST00000464357.1_5'UTR|LSS_ENST00000522411.1_Missense_Mutation_p.A239V	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	250					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					GTCTTCCGCGGCACTCAGCCG	0.652000													14	57					0	0	1	0	0
SHQ1	55164	broad.mit.edu	37	3	72842128	72842128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:72842128G>A	ENST00000325599.8	-	10	1259	c.1120C>T	c.(1120-1122)Cca>Tca	p.P374S	SHQ1_ENST00000463369.1_Missense_Mutation_p.P346S|SHQ1_ENST00000468371.1_5'UTR	NM_018130.2	NP_060600.2	Q6PI26	SHQ1_HUMAN	SHQ1, H/ACA ribonucleoprotein assembly factor	374					ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		ATGTACGCTGGGTCATTTTCC	0.308000													9	89					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247597450	247597450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247597450C>T	ENST00000366497.2	+	6	3153	c.2373C>T	c.(2371-2373)tcC>tcT	p.S791S	NLRP3_ENST00000366496.2_Silent_p.S791S|NLRP3_ENST00000336119.3_Silent_p.S791S|NLRP3_ENST00000348069.2_Silent_p.S734S|NLRP3_ENST00000391828.3_Silent_p.S791S|NLRP3_ENST00000391827.2_Silent_p.S734S	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	848					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCGACATCTCCTTGGTCCTCA	0.567000													40	100					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125367398	125367398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125367398G>A	ENST00000431078.1	+	12	2138	c.1774G>A	c.(1774-1776)Gag>Aag	p.E592K		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	592	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCAATCCTGCGAGGTGTACAG	0.517000													16	77					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77748454	77748454	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:77748454G>A	ENST00000407578.2	-	37	5909	c.5643C>T	c.(5641-5643)ctC>ctT	p.L1881L	MYCBP2_ENST00000357337.6_Silent_p.L1843L|MYCBP2_ENST00000544440.2_Silent_p.L1843L|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1843			A -> S (in dbSNP:rs35887505).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACCTATAGTAGAGTATCTGTG	0.433000													20	83					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23906980	23906980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:23906980G>A	ENST00000382298.3	-	10	11623	c.11035C>T	c.(11035-11037)Ctt>Ttt	p.L3679F	SACS_ENST00000402364.1_Missense_Mutation_p.L2929F|SACS_ENST00000382292.3_Missense_Mutation_p.L3679F	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3679					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AACTTTATAAGAGGAAGTGTT	0.408000													28	77					0	0	1	0	0
CERS6	253782	broad.mit.edu	37	2	169417815	169417815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169417815G>A	ENST00000305747.6	+	3	977	c.390G>A	c.(388-390)acG>acA	p.T130T	CERS6_ENST00000392687.4_Silent_p.T130T	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	130	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GCACGCTGACGAGGTTCTGTG	0.463000													39	112					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36260883	36260883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36260883C>T	ENST00000394571.2	+	3	484	c.484C>T	c.(484-486)Ccc>Tcc	p.P162S	PNPLA1_ENST00000388715.3_Missense_Mutation_p.P67S|PNPLA1_ENST00000312917.5_Missense_Mutation_p.P67S	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	162	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						TGGCCTCATCCCCCCGACTTA	0.652000													29	71					0	0	1	0	0
FAM50B	26240	broad.mit.edu	37	6	3850651	3850651	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:3850651G>A	ENST00000380274.1	+	1	1032	c.606G>A	c.(604-606)cgG>cgA	p.R202R	FAM50B_ENST00000380272.3_Silent_p.R202R			Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	202						nucleus				cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(3)|urinary_tract(3)	17	Ovarian(93;0.0925)	all_hematologic(90;0.108)				GCACGGTGCGGGTGCGCAAGG	0.672000													36	54					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29398864	29398864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:29398864G>A	ENST00000558402.1	+	13	2358	c.1759G>A	c.(1759-1761)Ggc>Agc	p.G587S	APBA2_ENST00000558259.1_Missense_Mutation_p.G587S|APBA2_ENST00000561069.1_Missense_Mutation_p.G587S|APBA2_ENST00000411764.1_Missense_Mutation_p.G575S|APBA2_ENST00000558330.1_Missense_Mutation_p.G575S			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	587	PDZ 1.				nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGTGGAGTCGGGCTGGGGCTC	0.652000													6	75					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7701593	7701593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7701593C>T	ENST00000572933.1	+	54	9809	c.8349C>T	c.(8347-8349)acC>acT	p.T2783T	DNAH2_ENST00000389173.2_Silent_p.T2783T			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2783	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACTACACCACCTTCCAGATCG	0.542000													30	33					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42821107	42821107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42821107G>A	ENST00000598766.1	+	11	964	c.964G>A	c.(964-966)Gag>Aag	p.E322K	TMEM145_ENST00000301204.3_Missense_Mutation_p.E298K			Q8NBT3	TM145_HUMAN	transmembrane protein 145	298						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				GCTCATCTACGAGGCGGAAGT	0.657000													11	29					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847485	123847485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123847485C>T	ENST00000531945.1	-	1	1003	c.914G>A	c.(913-915)cGg>cAg	p.R305Q		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTCCTTGTTCCGCAAAGTGTA	0.532000													54	89					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218683158	218683158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:218683158G>A	ENST00000171887.4	-	24	4037	c.3585C>T	c.(3583-3585)ttC>ttT	p.F1195F	TNS1_ENST00000419504.1_Silent_p.F1182F|TNS1_ENST00000430930.1_Silent_p.F1174F	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1195						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CCCGCCAGCCGAAGCCAGGAC	0.637000													37	66					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655306	46655306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46655306C>T	ENST00000253255.5	-	1	3913	c.3914G>A	c.(3913-3915)cGa>cAa	p.R1305Q		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1305	PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GCTAGGCGATCGACCCTCGTT	0.453000													16	105					0	0	1	0	0
HDGFL1	154150	broad.mit.edu	37	6	22570398	22570398	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:22570398C>T	ENST00000510882.2	+	1	604	c.594C>T	c.(592-594)ctC>ctT	p.L198L	HDGFL1_ENST00000230012.3_Silent_p.L198L			Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	198	Glu-rich.			L -> P (in Ref. 1; BAB71292).						kidney(1)|large_intestine(3)|lung(7)	11	Ovarian(93;0.163)					GTCCGTTCCTCGTGGCGGTGG	0.746000													3	6					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157244	22157244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22157244C>T	ENST00000397126.4	-	4	740	c.592G>A	c.(592-594)Gag>Aag	p.E198K	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAGGAATTCTCTCTAGTATAA	0.363000													28	58					0	0	1	0	0
DYDC2	84332	broad.mit.edu	37	10	82126582	82126582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:82126582C>T	ENST00000372199.1	+	6	1007	c.409C>T	c.(409-411)Cct>Tct	p.P137S	DYDC2_ENST00000372198.1_Missense_Mutation_p.P151S|DYDC2_ENST00000444807.2_Missense_Mutation_p.P137S|DYDC2_ENST00000372197.1_Missense_Mutation_p.P137S|DYDC2_ENST00000256039.2_Missense_Mutation_p.P137S			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	137							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			TCAACAGGTTCCTCCTTCAGA	0.473000													52	126					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108869898	108869898	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108869898G>A	ENST00000329106.2	+	3	399	c.399_splice	c.e3+1	p.K133_splice	SULT1C3_ENST00000376700.1_Splice_Site_p.K133_splice	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	133						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						AAAACTGCAAGGTATAAAGAG	0.338000													24	54					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7679435	7679435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7679435C>T	ENST00000256861.6	-	5	486	c.408G>A	c.(406-408)aaG>aaA	p.K136K	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Silent_p.K136K|ITIH5_ENST00000446830.2_5'UTR|ITIH5_ENST00000397145.2_Silent_p.K136K	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	136	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TTTCAGTCCCCTTCTCTCTGT	0.542000													7	78					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42563605	42563605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42563605C>T	ENST00000262895.3	-	5	582	c.583G>A	c.(583-585)Gac>Aac	p.D195N	GRIK5_ENST00000593562.1_Missense_Mutation_p.D195N|GRIK5_ENST00000301218.4_Missense_Mutation_p.D195N	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	195						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TCCCGGCTGTCGTCCAACATC	0.607000													36	71					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54159206	54159206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:54159206G>A	ENST00000404125.1	-	10	1137	c.1082C>T	c.(1081-1083)cCa>cTa	p.P361L	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	361					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AACACTGTTTGGCAACCGCTG	0.423000													16	173					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218683210	218683210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:218683210G>A	ENST00000171887.4	-	24	3985	c.3533C>T	c.(3532-3534)cCt>cTt	p.P1178L	TNS1_ENST00000419504.1_Missense_Mutation_p.P1165L|TNS1_ENST00000430930.1_Missense_Mutation_p.P1157L	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1178						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GCGCGCCTGAGGGCTCCCAGG	0.642000													31	53					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388705	48388705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48388705C>T	ENST00000224600.4	-	1	2286	c.2173G>A	c.(2173-2175)Gag>Aag	p.E725K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	725	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	TAGGTGAGCTCCTCTGGAGAG	0.617000													23	34					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7698957	7698957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:7698957G>A	ENST00000507866.2	+	12	1733	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K	SORCS2_ENST00000329016.9_Missense_Mutation_p.E370K	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	542						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						GGAATATAAAGAAGAAATGTA	0.547000													3	11					0	0	1	0	0
INTS4P2	644619	broad.mit.edu	37	7	65160009	65160009	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:65160009C>T	ENST00000430126.2	+	0	1179																											GTGTCATCAGCTGTTTCTCCC	0.463000													23	39					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49663596	49663596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49663596C>T	ENST00000339139.4	-	9	793	c.557G>A	c.(556-558)gGa>gAa	p.G186E		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	186						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			ACAAGGTGTTCCTTGTTGGTA	0.338000													22	61					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871842	51871842	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51871842G>A	ENST00000371497.5	+	2	2732	c.1845G>A	c.(1843-1845)ggG>ggA	p.G615G	TSHZ2_ENST00000329613.6_Silent_p.G612G|TSHZ2_ENST00000603338.2_Silent_p.G612G	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	615					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AGGAGTGTGGGAAAGAAAGTC	0.507000													9	114					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110535021	110535021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110535021G>A	ENST00000378402.5	+	75	12336	c.12232G>A	c.(12232-12234)Gcc>Acc	p.A4078T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	4078					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCATCACGTGGCCTTCGTGTC	0.512000										HNSCC(38;0.096)			11	29					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900372	151900372	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151900372G>A	ENST00000393900.3	-	3	782	c.429C>T	c.(427-429)ttC>ttT	p.F143F	MAGEA12_ENST00000393869.3_Silent_p.F143F|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Silent_p.F143F	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	143	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					AGAAGTCCTGGAAATTTCTGA	0.507000													100	66					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204587210	204587210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204587210G>A	ENST00000367175.1	-	1	4123	c.1911C>T	c.(1909-1911)ctC>ctT	p.L637L	LRRN2_ENST00000367176.3_Silent_p.L637L|LRRN2_ENST00000367177.3_Silent_p.L637L			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	637					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GAAGGACAGCGAGAGCCAGGA	0.647000													12	23					0	0	1	0	0
TBC1D25	4943	broad.mit.edu	37	X	48419014	48419014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48419014C>T	ENST00000376771.4	+	6	2059	c.1718C>T	c.(1717-1719)cCc>cTc	p.P573L	TBC1D25_ENST00000537536.1_Missense_Mutation_p.P319L|TBC1D25_ENST00000427713.1_3'UTR	NM_002536.2	NP_002527.1	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	573						intracellular	Rab GTPase activator activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GAGGCCTCTCCCACTGGTGAT	0.577000													41	53					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216595578	216595578	+	Missense_Mutation	SNP	C	C	T	rs141672841	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216595578C>T	ENST00000366943.2	-	2	487	c.101G>A	c.(100-102)cGa>cAa	p.R34Q	USH2A_ENST00000307340.3_Missense_Mutation_p.R34Q|USH2A_ENST00000366942.3_Missense_Mutation_p.R34Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	34					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAAAAGACCTCGTGACTCAGT	0.453000										HNSCC(13;0.011)			30	73					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113421178	113421178	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113421178G>A	ENST00000297405.5	-	33	5723	c.5479C>T	c.(5479-5481)Ctg>Ttg	p.L1827L	CSMD3_ENST00000352409.3_Intron|CSMD3_ENST00000343508.3_Silent_p.L1787L|CSMD3_ENST00000455883.2_Silent_p.L1723L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1827	CUB 10.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GAAGATAACAGAGAAGATTGC	0.418000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			37	130					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50610836	50610836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:50610836G>A	ENST00000371824.1	+	2	474	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	ELAVL4_ENST00000448907.2_Missense_Mutation_p.E76K|ELAVL4_ENST00000371823.4_Missense_Mutation_p.E73K|ELAVL4_ENST00000492299.1_3'UTR|ELAVL4_ENST00000371819.1_Missense_Mutation_p.E78K|ELAVL4_ENST00000371821.1_Missense_Mutation_p.E78K|ELAVL4_ENST00000371827.1_Missense_Mutation_p.E73K|ELAVL4_ENST00000357083.4_Missense_Mutation_p.E90K			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	73	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						TGGTGAAATAGAATCCTGCAA	0.413000													23	96					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54735313	54735313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54735313G>A	ENST00000306858.7	+	2	385	c.269G>A	c.(268-270)gGg>gAg	p.G90E		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	90										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTATCTTCAGGGACCTACTGG	0.443000													30	147					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4673781	4673781	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4673781G>A	ENST00000396952.5	+	2	675	c.25G>A	c.(25-27)Gaa>Aaa	p.E9K	OR51E1_ENST00000530215.1_Missense_Mutation_p.E9K	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	8			S -> N (in dbSNP:rs17224476).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAATGGCAATGAATCCAGTGC	0.488000													44	116					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95142932	95142932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95142932G>A	ENST00000027335.3	-	17	2444	c.2320C>T	c.(2320-2322)Cgg>Tgg	p.R774W	CDH17_ENST00000441892.2_Intron|CDH17_ENST00000450165.2_Missense_Mutation_p.R774W	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	774	Cadherin 7.					integral to membrane	calcium ion binding	p.R774W(1)		NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CCTGCTGGCCGGAAACAACTT	0.448000													15	34					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45279062	45279062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45279062C>T	ENST00000313237.5	-	13	1650	c.1500G>A	c.(1498-1500)acG>acA	p.T500T	PHF21B_ENST00000404079.2_Silent_p.T446T|PHF21B_ENST00000396103.3_Silent_p.T458T|PHF21B_ENST00000403565.1_Silent_p.T296T	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	500							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GGCTAGTGGTCGTCATGGTGA	0.701000													27	94					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147113688	147113688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:147113688C>T	ENST00000383075.3	-	3	1151	c.639G>A	c.(637-639)aaG>aaA	p.K213K	ZIC4_ENST00000484399.1_Silent_p.K213K|ZIC4_ENST00000473123.1_Silent_p.K213K|ZIC4_ENST00000525172.2_Silent_p.K263K|ZIC4_ENST00000425731.3_Silent_p.K251K|ZIC4_ENST00000491672.1_Intron	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	213						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						TAGCAAAGACCTTCCCACACC	0.537000													41	100					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344390	56344390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56344390C>T	ENST00000526812.2	-	1	873	c.808G>A	c.(808-810)Gag>Aag	p.E270K		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						ATTTTGGACTCCTCTACAGAC	0.423000													64	192					0	0	1	0	0
HNF1A	6927	broad.mit.edu	37	12	121434128	121434128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121434128C>T	ENST00000257555.6	+	5	1245	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	HNF1A_ENST00000400024.2_Missense_Mutation_p.P340L|HNF1A_ENST00000544413.1_Missense_Mutation_p.P340L|HNF1A_ENST00000538626.1_Intron|HNF1A_ENST00000543427.1_Missense_Mutation_p.P223L|HNF1A_ENST00000402929.1_Missense_Mutation_p.P340L|HNF1A_ENST00000541395.1_Missense_Mutation_p.P340L			P20823	HNF1A_HUMAN	HNF1 homeobox A	340					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGCGGCGGTCCCTTAGTGACA	0.617000									Hepatic Adenoma, Familial Clustering of				43	114					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628478	173628478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173628478G>A	ENST00000333279.2	-	2	140	c.80C>T	c.(79-81)gCc>gTc	p.A27V		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	43										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						tggttcttgggcttcttcttc	0.438000													9	22					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020050	56020050	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56020050C>T	ENST00000303059.3	+	1	375	c.375C>T	c.(373-375)atC>atT	p.I125I		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TTTCATTTATCGGATGTGCAA	0.358000													60	167					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104042572	104042572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104042572G>A	ENST00000388887.2	+	10	1349	c.1145G>A	c.(1144-1146)gGa>gAa	p.G382E		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	382	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AAATGGCAAGGAAGGCTGACC	0.443000													38	83					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874348	36874348	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36874348G>A	ENST00000301807.6	-	21	6841	c.4944C>T	c.(4942-4944)ttC>ttT	p.F1648F	TRANK1_ENST00000429976.2_Silent_p.F2198F|TRANK1_ENST00000428977.2_Silent_p.F1648F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2198					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGATTTTAGGGAATACTTTTT	0.403000													18	42					0	0	1	0	0
CKAP4	10970	broad.mit.edu	37	12	106633295	106633295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:106633295G>A	ENST00000378026.4	-	2	1452	c.1316C>T	c.(1315-1317)tCc>tTc	p.S439F		NM_006825.3	NP_006816.2	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	439						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction				NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|pancreas(1)|urinary_tract(1)	20						CTGGCTCTTGGACAGGAGGGA	0.687000													9	79					0	0	1	0	0
KDM5D	8284	broad.mit.edu	37	Y	21903332	21903332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:21903332G>A	ENST00000541639.1	-	5	681	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C	KDM5D_ENST00000317961.4_Missense_Mutation_p.R132C|KDM5D_ENST00000382806.2_Intron	NM_001146705.1	NP_001140177.1	Q9BY66	KDM5D_HUMAN	lysine (K)-specific demethylase 5D	132	ARID.				chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(1)|large_intestine(9)|lung(6)|skin(1)	17					Vitamin C(DB00126)	GCCCACCGACGATCCTTGCAG	0.478000													10	16					0	0	1	0	0
TPSG1	25823	broad.mit.edu	37	16	1272059	1272059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1272059C>T	ENST00000234798.4	-	6	699	c.695G>A	c.(694-696)gGt>gAt	p.G232D		NM_012467.3	NP_036599.3	Q9NRR2	TRYG1_HUMAN	tryptase gamma 1	232	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			liver(1)|lung(2)|skin(1)	4		Hepatocellular(780;0.00369)				CACCCAGGCACCGTTCACCTG	0.667000													17	41					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8180457	8180457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8180457G>A	ENST00000600128.1	-	30	4194	c.3780C>T	c.(3778-3780)tcC>tcT	p.S1260S	FBN3_ENST00000601739.1_Silent_p.S1260S|FBN3_ENST00000270509.2_Silent_p.S1260S			Q75N90	FBN3_HUMAN	fibrillin 3	1260	EGF-like 18; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GGCAGACAAAGGAACCCTTCG	0.612000													12	43					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48239742	48239742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48239742G>A	ENST00000263277.3	+	5	1283	c.1032G>A	c.(1030-1032)ctG>ctA	p.L344L	EHD2_ENST00000540884.1_3'UTR|EHD2_ENST00000538399.1_Silent_p.L208L	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	344					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		AGATTCAGCTGGAACATCACA	0.527000													36	53					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11400787	11400787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:11400787G>A	ENST00000259089.4	+	2	646	c.54G>A	c.(52-54)aaG>aaA	p.K18K	BLK_ENST00000529894.1_Intron	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	18					intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TCAAAGAGAAGGACAAGGGCC	0.607000													18	59					0	0	1	0	0
SLC47A1	55244	broad.mit.edu	37	17	19480832	19480832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:19480832G>A	ENST00000270570.4	+	17	1765	c.1679G>A	c.(1678-1680)gGg>gAg	p.G560E	SLC47A1_ENST00000571335.1_Missense_Mutation_p.G306E|SLC47A1_ENST00000395585.1_Intron|SLC47A1_ENST00000436810.2_3'UTR|SLC47A1_ENST00000575023.1_Missense_Mutation_p.G258E|SLC47A1_ENST00000457293.1_Intron|RP11-1113L8.1_ENST00000574267.1_RNA	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	560						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TTGCTGGTGGGGATTTTAGTG	0.502000													41	76					0	0	1	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130674663	130674663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130674663G>A	ENST00000335791.5	-	4	770	c.495C>T	c.(493-495)acC>acT	p.T165T	ST6GALNAC4_ENST00000495983.1_5'UTR|ST6GALNAC4_ENST00000343609.2_Silent_p.T81T	NM_175039.3	NP_778204.1	Q9H4F1	SIA7D_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	165					glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7						GCGTGCGGTAGGTGCGGCCGC	0.632000													22	62					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239010604	239010604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239010604C>T	ENST00000343063.3	+	2	580	c.317C>T	c.(316-318)tCc>tTc	p.S106F	ESPNL_ENST00000409169.1_Missense_Mutation_p.S106F	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	106										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		TCGGGCGTCTCCCCGCTGCAC	0.706000													7	13					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60183867	60183867	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60183867G>A	ENST00000300187.6	+	5	1703	c.1426G>A	c.(1426-1428)Gaa>Aaa	p.E476K	MS4A14_ENST00000531787.1_Missense_Mutation_p.E364K|MS4A14_ENST00000395005.2_Missense_Mutation_p.E459K|MS4A14_ENST00000531783.1_Missense_Mutation_p.E509K	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	476	Gln-rich.					integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						ATCTGAGGAGGAACTCCATAG	0.383000													12	98					0	0	1	0	0
NAA35	60560	broad.mit.edu	37	9	88611379	88611379	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:88611379C>T	ENST00000361671.5	+	12	1076	c.943C>T	c.(943-945)Cga>Tga	p.R315*		NM_024635.3	NP_078911.3	Q5VZE5	NAA35_HUMAN	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	315					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	25						TACCTTCCCTCGATATGCAAA	0.313000													9	67					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98355350	98355350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98355350G>A	ENST00000339364.5	-	17	2521	c.2402C>T	c.(2401-2403)cCa>cTa	p.P801L	PIK3AP1_ENST00000371110.2_Missense_Mutation_p.P623L|PIK3AP1_ENST00000371109.3_Missense_Mutation_p.P400L	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	801	Pro-rich.					cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		TCCTCTGGGTGGAACAGGTGG	0.428000													18	42					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9036102	9036102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9036102G>A	ENST00000383836.3	-	19	2760	c.2333C>T	c.(2332-2334)tCg>tTg	p.S778L	SRGAP3_ENST00000360413.3_Missense_Mutation_p.S754L	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	778	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCAGTCCTCCGAGGCGCGGTG	0.587000			T	RAF1	pilocytic astrocytoma								29	80					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49776046	49776046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:49776046C>T	ENST00000492622.2	+	24	3403	c.3098C>T	c.(3097-3099)cCc>cTc	p.P1033L	FNDC3A_ENST00000541916.1_Missense_Mutation_p.P1033L|FNDC3A_ENST00000398316.3_Missense_Mutation_p.P977L	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1033	Fibronectin type-III 8.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		GGGGAAGGTCCCCTCTCCCAA	0.353000													27	83					0	0	1	0	0
NAT16	375607	broad.mit.edu	37	7	100817986	100817986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100817986C>T	ENST00000300303.2	-	2	341	c.103G>A	c.(103-105)Gag>Aag	p.E35K	NAT16_ENST00000455377.1_Missense_Mutation_p.E35K|NAT16_ENST00000443096.1_Missense_Mutation_p.E35K	NM_198571.2	NP_940973.2	Q8N8M0	CG052_HUMAN	N-acetyltransferase 16 (GCN5-related, putative)	35							N-acetyltransferase activity	p.E35K(1)									GCCTCCACCTCCTGTGGCCGG	0.637000													32	90					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19195292	19195292	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19195292G>A	ENST00000562034.1	+	3	4389	c.591G>A	c.(589-591)gaG>gaA	p.E197E	SYT17_ENST00000355377.2_Silent_p.E258E|SYT17_ENST00000568115.1_Silent_p.E197E|SYT17_ENST00000562711.2_Silent_p.E254E			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	258	C2 1.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						TGTTTGAGGAGCGCTACACCT	0.572000													19	137					0	0	1	0	0
RSAD2	91543	broad.mit.edu	37	2	7018127	7018127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:7018127C>T	ENST00000382040.3	+	1	332	c.196C>T	c.(196-198)Cct>Tct	p.P66S		NM_080657.4	NP_542388.2	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing 2	66					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)	20	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		GGAAGAGGACCCTCCTCTGCC	0.552000													23	57					0	0	1	0	0
TAF8	129685	broad.mit.edu	37	6	42034064	42034064	+	Silent	SNP	C	C	T	rs80150955	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42034064C>T	ENST00000372977.3	+	6	522	c.504C>T	c.(502-504)ccC>ccT	p.P168P	TAF8_ENST00000494547.1_Silent_p.P168P|TAF8_ENST00000372982.4_Silent_p.P168P|TAF8_ENST00000465926.1_Silent_p.P105P|TAF8_ENST00000456846.2_Silent_p.P168P	NM_138572.2	NP_612639.2	Q7Z7C8	TAF8_HUMAN	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa	168					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			ACCGTGAGCCCGTGTCAGACT	0.577000													15	32					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95680230	95680230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95680230C>T	ENST00000433389.2	+	10	1175	c.985C>T	c.(985-987)Cgc>Tgc	p.R329C	ESRP1_ENST00000358397.5_Missense_Mutation_p.R329C|ESRP1_ENST00000454170.2_Missense_Mutation_p.R329C|ESRP1_ENST00000423620.2_Missense_Mutation_p.R329C	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	329	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						AGTCATTGTCCGCATGCGGGG	0.483000													14	49					0	0	1	0	0
RNFT2	84900	broad.mit.edu	37	12	117271695	117271695	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117271695C>T	ENST00000257575.4	+	8	1214	c.981C>T	c.(979-981)tcC>tcT	p.S327S	RNFT2_ENST00000392549.2_Silent_p.S327S|RNFT2_ENST00000407967.3_Silent_p.S327S|RNFT2_ENST00000319176.7_Intron			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	327						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		ACGACTCCTCCAACAGCTACT	0.582000													8	24					0	0	1	0	0
SAMD12	401474	broad.mit.edu	37	8	119391794	119391794	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:119391794G>A	ENST00000314727.4	-	4	604	c.468C>T	c.(466-468)acC>acT	p.T156T	SAMD12_ENST00000527515.1_Intron|AC023590.1_ENST00000430457.1_Intron|SAMD12_ENST00000409003.4_Intron	NM_207506.2	NP_997389.2	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12	156										endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)	9	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			GAAGCAATAGGGTACCTTGTG	0.473000													17	62					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27744833	27744833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27744833G>A	ENST00000430629.2	-	4	571	c.356C>T	c.(355-357)cCt>cTt	p.P119L	WASF2_ENST00000536657.1_Missense_Mutation_p.P119L	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	119					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TTCTAAGACAGGCACTGGGAG	0.458000													33	91					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57060874	57060874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57060874C>T	ENST00000436936.1	+	6	2244	c.2019C>T	c.(2017-2019)ccC>ccT	p.P673P	NLRC5_ENST00000308149.7_Silent_p.P673P|NLRC5_ENST00000539144.1_Silent_p.P673P|NLRC5_ENST00000262510.6_Silent_p.P673P			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	673					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				ATGGCTGTCCCCTGGAGCCCC	0.597000													24	47					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47405691	47405691	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47405691G>A	ENST00000295454.3	+	7	1090	c.798G>A	c.(796-798)tgG>tgA	p.W266*	GABRB1_ENST00000538619.1_Nonsense_Mutation_p.W196*	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	266					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TGTCTTTTTGGATCAACTATG	0.383000													12	72					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625476	140625476	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140625476G>A	ENST00000231173.3	+	1	330	c.330G>A	c.(328-330)ctG>ctA	p.L110L		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		110	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGTGTTACTGAAAAAACCTT	0.438000													46	116					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833963	61833963	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61833963C>T	ENST00000280772.1	-	37	6867	c.6676G>A	c.(6676-6678)Gaa>Aaa	p.E2226K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2226					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TCATCTTCTTCACTACTGGCT	0.408000													31	136					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42237142	42237142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42237142C>T	ENST00000541110.1	-	5	755	c.187G>A	c.(187-189)Gat>Aat	p.D63N	TRERF1_ENST00000354325.2_Missense_Mutation_p.D63N|TRERF1_ENST00000340840.2_Missense_Mutation_p.D63N|TRERF1_ENST00000372917.4_Missense_Mutation_p.D63N|TRERF1_ENST00000372922.4_Missense_Mutation_p.D63N			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	63					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCCAGACCATCCCGTGTATCT	0.587000													28	108					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150648860	150648860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150648860G>A	ENST00000392968.2	-	5	2453	c.1333C>T	c.(1333-1335)Cgc>Tgc	p.R445C	KCNH2_ENST00000330883.4_Missense_Mutation_p.R201C|KCNH2_ENST00000430723.3_Missense_Mutation_p.R541C|KCNH2_ENST00000262186.5_Missense_Mutation_p.R541C			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	541					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TCTGAGTAGCGATCCAGCTTC	0.642000													7	32					0	0	1	0	0
SUCLA2	8803	broad.mit.edu	37	13	48571090	48571090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:48571090G>A	ENST00000378654.3	-	2	215	c.159C>T	c.(157-159)ctC>ctT	p.L53L	SUCLA2_ENST00000543413.1_5'UTR|SUCLA2_ENST00000544100.1_5'UTR|SUCLA2_ENST00000534875.1_5'UTR|SUCLA2_ENST00000497202.1_5'UTR	NM_003850.2	NP_003841.1	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	53					succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(4)	15		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	CATGTAGTGAGAGATTCCTTT	0.403000													29	59					0	0	1	0	0
RNF216	54476	broad.mit.edu	37	7	5662644	5662644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5662644G>A	ENST00000425013.2	-	17	2672	c.2448C>T	c.(2446-2448)ttC>ttT	p.F816F	RNF216_ENST00000389902.3_Silent_p.F873F|RNF216_ENST00000469375.1_5'UTR	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	816	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		GGAAGTTGTTGAACACAGGCC	0.652000													33	119					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176008478	176008478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176008478G>A	ENST00000510636.1	+	17	2227	c.1953G>A	c.(1951-1953)gaG>gaA	p.E651E	CDHR2_ENST00000261944.5_Silent_p.E651E|CDHR2_ENST00000506348.1_Silent_p.E651E	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	651	Cadherin 6.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TGGACAGAGAGGCCATCGACC	0.622000													18	50					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17250265	17250265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:17250265G>A	ENST00000285681.2	+	24	3415	c.3046G>A	c.(3046-3048)Gat>Aat	p.D1016N	USP25_ENST00000400183.2_Missense_Mutation_p.D1054N|USP25_ENST00000351097.5_Missense_Mutation_p.D379N|USP25_ENST00000285679.6_Missense_Mutation_p.D984N			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	984					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AGCTGTAGAAGATATGAGAAA	0.363000													13	59					0	0	1	0	0
CD3D	915	broad.mit.edu	37	11	118211092	118211092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118211092C>T	ENST00000300692.4	-	2	408	c.272G>A	c.(271-273)cGa>cAa	p.R91Q	CD3D_ENST00000529594.1_Intron|CD3D_ENST00000392884.2_Missense_Mutation_p.R91Q	NM_000732.4	NP_000723.1	P04234	CD3D_HUMAN	CD3d molecule, delta (CD3-TCR complex)	91					positive thymic T cell selection|T cell costimulation|T cell receptor signaling pathway	cytoplasm|integral to membrane	protein heterodimerization activity			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	9	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		GCACGTACTTCGATAATGAAC	0.463000													14	55					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086302	100086302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100086302C>T	ENST00000423930.1	+	4	1117	c.958C>T	c.(958-960)Cct>Tct	p.P320S	NYAP1_ENST00000300179.2_Missense_Mutation_p.P320S|NYAP1_ENST00000454988.1_Missense_Mutation_p.P263S			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	320	Pro-rich.																CAAGACCACTCCTTGTGAAAT	0.687000													48	102					0	0	1	0	0
CYP4V2	285440	broad.mit.edu	37	4	187131739	187131739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187131739C>T	ENST00000378802.4	+	11	1826	c.1522C>T	c.(1522-1524)Cgt>Tgt	p.R508C	CYP4V2_ENST00000502665.1_3'UTR	NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	508			R -> H (in BCD).		response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		GTTGATTCTTCGTCCAAGTAA	0.403000													22	76					0	0	1	0	0
SF3A1	10291	broad.mit.edu	37	22	30742481	30742481	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30742481G>A	ENST00000439242.1	-	3	344	c.213C>T	c.(211-213)atC>atT	p.I71I	SF3A1_ENST00000215793.7_Silent_p.I71I	NM_001005409.1	NP_001005409.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	71					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						CGTTCTGTCGGATCCTAGCTT	0.483000													44	92					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10792813	10792813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10792813C>T	ENST00000449870.1	+	12	1642	c.1325C>T	c.(1324-1326)tCa>tTa	p.S442L	ILF3_ENST00000588657.1_Missense_Mutation_p.S442L|ILF3_ENST00000250241.8_Missense_Mutation_p.S442L|ILF3_ENST00000318511.3_Missense_Mutation_p.S442L|ILF3_ENST00000420083.1_Missense_Mutation_p.S442L|ILF3_ENST00000407004.3_Missense_Mutation_p.S442L|ILF3_ENST00000589998.1_Missense_Mutation_p.S442L|ILF3_ENST00000592763.1_Missense_Mutation_p.S442L|ILF3_ENST00000590261.1_Missense_Mutation_p.S442L	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	442	DRBM 1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GATGGCAATTCATTCGAGGCC	0.557000													7	77					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241953905	241953905	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:241953905G>A	ENST00000366552.2	+	24	3081	c.2874G>A	c.(2872-2874)atG>atA	p.M958I	WDR64_ENST00000437684.2_Missense_Mutation_p.M791I	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	958										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			GGAGAAAAATGAGCTCAGTGT	0.388000													18	239					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46658501	46658501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46658501C>T	ENST00000544460.1	+	1	2890	c.2636C>T	c.(2635-2637)gCt>gTt	p.A879V	TDRD6_ENST00000316081.6_Missense_Mutation_p.A879V	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	879					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AAGGCACAGGCTTTTAGGTGC	0.328000													42	131					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179452434	179452434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179452434C>T	ENST00000589042.1	-	306	63826	c.63602G>A	c.(63601-63603)cGa>cAa	p.R21201Q	TTN_ENST00000342992.6_Missense_Mutation_p.R18633Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R12136Q|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R12328Q|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R12261Q|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R19560Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19560	Fibronectin type-III 54.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGGGCTGGTCGTCCTCTCAC	0.478000													15	33					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118360862	118360862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118360862C>T	ENST00000534358.1	+	13	4617	c.4594C>T	c.(4594-4596)Cgc>Tgc	p.R1532C	KMT2A_ENST00000389506.5_Missense_Mutation_p.R1532C|KMT2A_ENST00000354520.4_Missense_Mutation_p.R1494C	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CAAGTGTGTTCGCTGTAAGAG	0.383000													14	52					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123593738	123593738	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123593738C>T	ENST00000340011.5	+	3	471	c.114C>T	c.(112-114)ttC>ttT	p.F38F	SPAM1_ENST00000460182.1_Silent_p.F38F|SPAM1_ENST00000439500.1_Silent_p.F38F|SPAM1_ENST00000223028.7_Silent_p.F38F|SPAM1_ENST00000402183.2_Silent_p.F38F	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	38					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	CTCTGAATTTCAGAGCACCTC	0.413000													6	58					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100730827	100730827	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100730827C>T	ENST00000306085.6	+	3	531	c.234C>T	c.(232-234)ttC>ttT	p.F78F		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	78					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAACTTCTTCGTCAATGGGC	0.692000													45	78					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32172034	32172034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32172034C>T	ENST00000375023.3	-	19	3136	c.2998G>A	c.(2998-3000)Ggg>Agg	p.G1000R		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1000	EGF-like 25.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						CAGCGTAGCCCCACAAAGCCT	0.592000													20	47					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848336	123848336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123848336C>T	ENST00000531945.1	-	1	152	c.63G>A	c.(61-63)gtG>gtA	p.V21V		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AGTGGCTCACCACAGTCTGGT	0.488000													31	76					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184293694	184293694	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184293694C>T	ENST00000330394.2	+	4	1385	c.933C>T	c.(931-933)acC>acT	p.T311T	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	311	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCCGTACCACCTCCCCAGCCG	0.617000													37	118					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41729504	41729504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:41729504G>A	ENST00000242208.4	-	3	1271	c.1025C>T	c.(1024-1026)cCc>cTc	p.P342L	INHBA_ENST00000464515.1_5'UTR|AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000442711.1_Missense_Mutation_p.P342L	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	342					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						ATAGCCAGAGGGAGCAATGAT	0.537000										TSP Lung(11;0.080)			30	103					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17007100	17007100	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17007100C>T	ENST00000443236.1	-	41	5485	c.5454G>A	c.(5452-5454)ggG>ggA	p.G1818G	CPAMD8_ENST00000597335.1_5'UTR	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1771						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CCAGGTCATCCCCGTAGGTGG	0.692000													11	22					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31282318	31282318	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31282318C>T	ENST00000544665.3	+	6	542	c.471C>T	c.(469-471)ggC>ggT	p.G157G	ITGAM_ENST00000287497.8_Silent_p.G157G	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	157	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TGATTGATGGCTCTGGTAGCA	0.458000													59	218					0	0	1	0	0
SMOX	54498	broad.mit.edu	37	20	4162831	4162831	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:4162831C>T	ENST00000305958.4	+	5	930	c.705C>T	c.(703-705)atC>atT	p.I235I	SMOX_ENST00000346595.2_Intron|SMOX_ENST00000278795.3_Silent_p.I235I|SMOX_ENST00000339123.6_Silent_p.I235I|SMOX_ENST00000379460.2_Silent_p.I235I	NM_175839.1	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	235					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	ACCACATCATCCCCTCGGGCT	0.647000													28	42					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25307511	25307511	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25307511C>T	ENST00000549804.2	+	0	397				SNORD116-5_ENST00000384462.1_RNA																							TAAAAACATTCCTTGGAAAAG	0.507000													35	192					0	0	1	0	0
C5orf20	140947	broad.mit.edu	37	5	134782265	134782265	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134782265C>T	ENST00000503143.2	-	1	773	c.534G>A	c.(532-534)ctG>ctA	p.L178L	TIFAB_ENST00000537858.1_3'UTR	NM_130848.2	NP_570900.1	Q8TF63	DCNP1_HUMAN	chromosome 5 open reading frame 20	178	Ser-rich.					nucleus				endometrium(1)|lung(1)|prostate(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTGATGATTTCAGTGATTTTC	0.488000													27	80					0	0	1	0	0
CAPN12	147968	broad.mit.edu	37	19	39228192	39228192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39228192C>T	ENST00000328867.4	-	9	1360	c.1052G>A	c.(1051-1053)gGg>gAg	p.G351E	CAPN12_ENST00000601953.1_Missense_Mutation_p.G202E	NM_144691.3	NP_653292.2	Q6ZSI9	CAN12_HUMAN	calpain 12	351	Domain III.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CCAGCCGCCCCCCTCCGGGCT	0.692000													17	32					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154624622	154624622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:154624622G>A	ENST00000260010.6	+	1	1971	c.563G>A	c.(562-564)aGc>aAc	p.S188N		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	188					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				GATCTACAGAGCTATGAGCCA	0.368000													38	48					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982054	7982054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7982054C>T	ENST00000328600.2	-	2	1266	c.1105G>A	c.(1105-1107)Gag>Aag	p.E369K		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	369	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTGCCTCTCTCCATCTGCCCC	0.527000													16	38					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101887979	101887979	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101887979T>A	ENST00000398181.2	-	15	2172	c.1859A>T	c.(1858-1860)aAc>aTc	p.N620I	PCSK6_ENST00000561177.1_Intron|PCSK6_ENST00000344273.2_Missense_Mutation_p.E635D|PCSK6_ENST00000348070.1_Intron|PCSK6_ENST00000358417.3_Intron	NM_138323.1|NM_138325.2	NP_612196.1|NP_612198.2	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	621	Homo B/P.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ttagtccaggttccctggaaa	0.512000													32	95					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31302255	31302255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31302255G>A	ENST00000265071.2	+	6	1114	c.849G>A	c.(847-849)ccG>ccA	p.P283P	CDH6_ENST00000514738.1_Silent_p.P228P	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	283	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CTTCTCCACCGGGGACACCAA	0.423000													14	39					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196682553	196682553	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196682553C>T	ENST00000312428.6	-	50	9392	c.9291_splice	c.e50-1	p.V3098_splice		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3098	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATAATGTTACCTATAAATGA	0.338000													4	22					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	100996191	100996191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:100996191G>A	ENST00000284382.4	-	12	1329	c.906C>T	c.(904-906)atC>atT	p.I302I	CERS3_ENST00000394113.1_Silent_p.I302I|CERS3_ENST00000538112.2_Silent_p.I302I|CERS3_ENST00000560944.1_Intron	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	302	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GGTTGAGGAAGATGTATGAAA	0.398000													19	90					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56368991	56368991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56368991G>A	ENST00000587891.1	+	1	181	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K	NLRP4_ENST00000346986.5_Intron|NLRP4_ENST00000301295.6_Intron			Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	0	DAPIN.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ATATATGCAGGAATGCTTAAC	0.453000													11	27					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9045944	9045944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9045944G>A	ENST00000397910.4	-	5	35890	c.35687C>T	c.(35686-35688)tCc>tTc	p.S11896F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11898	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACAGCAGGGGAAACAGTCAG	0.488000													7	119					0	0	1	0	0
CHI3L2	1117	broad.mit.edu	37	1	111781455	111781455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111781455C>T	ENST00000445067.2	+	10	1590	c.819C>T	c.(817-819)ttC>ttT	p.F273F	CHI3L2_ENST00000369744.2_Silent_p.F263F|CHI3L2_ENST00000524472.1_Silent_p.F194F|CHI3L2_ENST00000369748.4_Silent_p.F273F|CHI3L2_ENST00000466741.1_Silent_p.F194F			Q15782	CH3L2_HUMAN	chitinase 3-like 2	273					chitin catabolic process	extracellular space	cation binding|chitinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(1)	19		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		GGCACTCCTTCACACTGGCCT	0.562000													64	167					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505221	37505221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37505221G>A	ENST00000374660.1	+	38	3270	c.3171G>A	c.(3169-3171)aaG>aaA	p.K1057K	ANKRD30A_ENST00000602533.1_Silent_p.K938K|ANKRD30A_ENST00000361713.1_Silent_p.K938K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1060						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AAATGAAAAAGAAGTTTTGTG	0.338000													13	75					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21211172	21211172	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21211172C>T	ENST00000574002.1	-	16	2204	c.1722G>A	c.(1720-1722)caG>caA	p.Q574Q	ZP2_ENST00000219593.4_Silent_p.Q574Q|AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Silent_p.Q565Q			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	574	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		GGAAGGTGGTCTGGTAGTTGT	0.493000													15	66					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23865624	23865624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23865624G>A	ENST00000405093.3	-	20	2368	c.2298C>T	c.(2296-2298)ttC>ttT	p.F766F	MYH6_ENST00000356287.3_Silent_p.F766F	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	766	Actin-binding.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CTGCCTTGAAGAACACCTGCA	0.642000													11	34					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168176541	168176541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168176541C>T	ENST00000519560.1	-	19	2492	c.2073G>A	c.(2071-2073)caG>caA	p.Q691Q	SLIT3_ENST00000332966.8_Silent_p.Q691Q|SLIT3_ENST00000404867.3_Silent_p.Q691Q	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	691	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAATGGCTTCTGGCACCTAG	0.572000													38	81					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29275004	29275004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29275004C>T	ENST00000377160.2	+	1	602	c.538C>T	c.(538-540)Cct>Tct	p.P180S		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						CTGTGATGTTCCTCAGATGCT	0.453000													36	154					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227898144	227898144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227898144C>T	ENST00000396625.3	-	38	3766	c.3559G>A	c.(3559-3561)Gga>Aga	p.G1187R	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1187R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1187	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTTTAGTTCCTTTCTGACCT	0.512000											OREG0015250	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	38					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102309921	102309921	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:102309921C>T	ENST00000438793.3	+	14	1734	c.1264C>T	c.(1264-1266)Ctg>Ttg	p.L422L	PAM_ENST00000274392.9_Silent_p.L325L|PAM_ENST00000379787.4_5'UTR|PAM_ENST00000304400.7_Silent_p.L422L|PAM_ENST00000348126.2_Intron|PAM_ENST00000455264.2_Silent_p.L422L|PAM_ENST00000346918.2_Silent_p.L422L	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	422	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	AGAGTCAGACCTGGTAGCTGA	0.423000													17	73					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38835841	38835841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38835841C>T	ENST00000359357.3	+	46	6300	c.6046C>T	c.(6046-6048)Cat>Tat	p.H2016Y	DNAH8_ENST00000449981.2_Missense_Mutation_p.H2233Y|DNAH8_ENST00000441566.1_Missense_Mutation_p.H1980Y					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATCTCAGGTTCATTATGACTT	0.373000													21	75					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539691	94539691	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94539691G>A	ENST00000289495.5	+	1	482	c.266G>A	c.(265-267)gGg>gAg	p.G89E	PPP1R9A_ENST00000340694.4_Missense_Mutation_p.G89E|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.G89E|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.G89E|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.G89E|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.G89E	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	89	Actin-binding.					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAACAAGGGGGAAAGGTGGA	0.418000										HNSCC(28;0.073)			23	36					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66223165	66223165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:66223165C>T	ENST00000409699.2	-	11	1576	c.1404G>A	c.(1402-1404)aaG>aaA	p.K468K	MEGF11_ENST00000395625.2_Silent_p.K393K|MEGF11_ENST00000288745.3_Silent_p.K393K|MEGF11_ENST00000395614.1_5'UTR|MEGF11_ENST00000360698.4_Silent_p.K468K|MEGF11_ENST00000422354.1_Silent_p.K468K			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	468	EGF-like 8.					basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						CATTACCTTCCTTGCAGGTAC	0.587000													54	78					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100348997	100348997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100348997G>A	ENST00000437033.2	-	5	1000	c.497C>T	c.(496-498)cCt>cTt	p.P166L	ADH7_ENST00000209665.4_Missense_Mutation_p.P178L|ADH7_ENST00000476959.1_Missense_Mutation_p.P186L|ADH7_ENST00000482593.1_Missense_Mutation_p.P109L			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	178					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	GACTTTCTCAGGAGGAGCTGC	0.443000													15	62					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87970614	87970614	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:87970614C>G	ENST00000369577.3	+	8	7310	c.7267C>G	c.(7267-7269)Ctt>Gtt	p.L2423V	ZNF292_ENST00000339907.4_Missense_Mutation_p.L2418V	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ACACCGAAATCTTCTTATTGT	0.353000													7	11					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	619829	619829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:619829C>T	ENST00000255622.6	+	1	457	c.414C>T	c.(412-414)gtC>gtT	p.V138V	PDE6B_ENST00000496514.1_Silent_p.V138V	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	138	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						ACATCGGGGTCGTGGGCCACG	0.647000													6	9					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87040429	87040429	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87040429A>T	ENST00000370563.3	+	10	1716	c.1674A>T	c.(1672-1674)ggA>ggT	p.G558G	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	558						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GTATTCCAGGAACTGCAAAGG	0.383000													12	62					0	0	1	0	0
LOC101927958	101927958	broad.mit.edu	37	2	239141393	239141393	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239141393G>A	ENST00000456601.1	+	0	906																											GCCAGCCAGCGAAGCAGCCAG	0.532000													9	20					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161292786	161292786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:161292786C>T	ENST00000428797.2	+	5	602	c.247C>T	c.(247-249)Cat>Tat	p.H83Y	GABRA1_ENST00000420560.1_Missense_Mutation_p.H83Y|GABRA1_ENST00000444819.1_Missense_Mutation_p.H83Y|GABRA1_ENST00000437025.2_Missense_Mutation_p.H83Y|GABRA1_ENST00000023897.6_Missense_Mutation_p.H83Y|GABRA1_ENST00000393943.4_Missense_Mutation_p.H83Y	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	83					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CGTTTCAGACCATGATATGGT	0.388000													52	136					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175836	143175836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143175836C>T	ENST00000408916.1	+	1	871	c.871C>T	c.(871-873)Cga>Tga	p.R291*	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	291					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					CCTCAAGCTTCGAAGCGTGTT	0.502000													21	57					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72840925	72840925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72840925G>A	ENST00000377182.4	+	14	2655	c.2038G>A	c.(2038-2040)Gac>Aac	p.D680N	SMC5-AS1_ENST00000594708.1_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	680						endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						ATATTCTGAGGACTTAAATGA	0.274000													14	68					0	0	1	0	0
GSTA3	2940	broad.mit.edu	37	6	52764831	52764831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52764831C>T	ENST00000211122.3	-	5	380	c.315G>A	c.(313-315)atG>atA	p.M105I	GSTA3_ENST00000370968.1_Missense_Mutation_p.M55I	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	105	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	GAAGAAGGATCATTTCATTCA	0.383000													61	188					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55142266	55142266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55142266C>T	ENST00000370862.3	+	5	1187	c.851C>T	c.(850-852)tCc>tTc	p.S284F		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	284					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCAACGAAGTCCCGGATGAGC	0.502000													13	46					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25514967	25514967	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25514967G>A	ENST00000554726.1	+	0	47				SNORD115-48_ENST00000364764.1_RNA|SNHG14_ENST00000452731.1_RNA																							GAGAAATGATGACGTAAAAAT	0.423000													24	59					0	0	1	0	0
PTGIR	5739	broad.mit.edu	37	19	47124812	47124812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47124812G>A	ENST00000291294.2	-	3	1019	c.886C>T	c.(886-888)Cgc>Tgc	p.R296C	PTGIR_ENST00000598865.1_Missense_Mutation_p.R84C|PTGIR_ENST00000594275.1_Missense_Mutation_p.R53C|PTGIR_ENST00000597185.1_Missense_Mutation_p.R25C	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	296					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	ACAGCCTTGCGGAAAAGGATG	0.637000													22	64					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119045960	119045960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119045960C>T	ENST00000409109.1	+	6	2235	c.1648C>T	c.(1648-1650)Cct>Tct	p.P550S	NLRX1_ENST00000525863.1_Missense_Mutation_p.P550S|NLRX1_ENST00000409265.4_Missense_Mutation_p.P550S|NLRX1_ENST00000409991.1_Missense_Mutation_p.P550S|NLRX1_ENST00000292199.2_Missense_Mutation_p.P550S			Q86UT6	NLRX1_HUMAN	NLR family member X1	550	Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCGGGCTCTGCCTCTGCTCTT	0.627000													35	66					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36091363	36091363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:36091363G>A	ENST00000378660.1	+	4	486	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	CHDC2_ENST00000313548.4_Missense_Mutation_p.E100K					calponin homology domain containing 2																		TTCTCTTGAGGAAGGAACAAA	0.413000													40	46					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139113755	139113755	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139113755G>A	ENST00000358701.5	-	6	745	c.708C>T	c.(706-708)atC>atT	p.I236I		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	236					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		GGGTCACCACGATGCTTTCAT	0.512000													27	74					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17482038	17482038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17482038G>A	ENST00000302539.4	-	6	1133	c.1008C>T	c.(1006-1008)ccC>ccT	p.P336P	ABCC8_ENST00000389817.3_Silent_p.P336P	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	336	ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGCCTACCTTGGGCTGGAAGA	0.582000													42	109					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130765006	130765006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:130765006G>A	ENST00000276708.4	-	7	1663	c.782C>T	c.(781-783)tCa>tTa	p.S261L		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	261						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						ggtatgaaatgatggtagcaa	0.433000													7	80					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189705318	189705318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189705318C>T	ENST00000319332.5	-	5	1293	c.1096G>A	c.(1096-1098)Gag>Aag	p.E366K	LEPREL1_ENST00000427335.2_Missense_Mutation_p.E185K	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	366					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGTCTCACCTCTCTGGCCTCA	0.418000													18	30					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54798330	54798330	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54798330C>T	ENST00000474759.1	+	13	1380	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	CACNA2D3_ENST00000415676.2_Silent_p.I444I|CACNA2D3_ENST00000288197.5_Silent_p.I444I|CACNA2D3_ENST00000490478.1_Silent_p.I350I	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	444						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CCAAAGTCATCGACCAGGAGC	0.522000													40	86					0	0	1	0	0
MIP	4284	broad.mit.edu	37	12	56847477	56847477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56847477G>A	ENST00000257979.4	-	2	451	c.423C>T	c.(421-423)ttC>ttT	p.F141F	MIP_ENST00000555551.1_5'UTR	NM_012064.3	NP_036196.1	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	141					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	16						TGCAGAGCACGAACTGGAGCG	0.607000													19	27					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151156369	151156369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151156369G>A	ENST00000282466.3	-	6	5979	c.5980C>T	c.(5980-5982)Cac>Tac	p.H1994Y	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1994	Ig-like C2-type 6.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGGTAGACGTGGATCCAGCTG	0.458000													15	43					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49219042	49219042	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49219042G>A	ENST00000327979.2	-	13	1625	c.1214C>T	c.(1213-1215)tCc>tTc	p.S405F	FAM65C_ENST00000045083.2_Missense_Mutation_p.S405F|FAM65C_ENST00000535356.1_Missense_Mutation_p.S409F			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	405										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGAGCTGAAGGAGTCCATCTC	0.637000													20	67					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784685	9784685	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9784685C>T	ENST00000304374.2	+	1	1428	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	344					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TCGACGTCTTCGTCTGGTTCG	0.592000													19	138					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19516253	19516253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:19516253C>T	ENST00000341998.2	-	10	1945	c.1884G>A	c.(1882-1884)atG>atA	p.M628I	SLC24A2_ENST00000286344.3_Missense_Mutation_p.M611I	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	628					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGATTTTGTTCATTCGCCACT	0.502000													60	88					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166179783	166179783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166179783G>A	ENST00000375437.2	+	12	2079	c.1789G>A	c.(1789-1791)Gag>Aag	p.E597K	SCN2A_ENST00000375427.2_Missense_Mutation_p.E597K|SCN2A_ENST00000357398.3_Missense_Mutation_p.E597K|SCN2A_ENST00000283256.6_Missense_Mutation_p.E597K	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	597					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	TGCTGATGATGAGCACAGCAC	0.547000													16	59					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124623552	124623552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124623552G>A	ENST00000278927.5	-	7	1292	c.1163C>T	c.(1162-1164)tCt>tTt	p.S388F	ESAM_ENST00000442070.2_Intron	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	388					blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		TCATACCAGAGAGCCAGCTTG	0.557000													27	49					0	0	1	0	0
MTRF1	9617	broad.mit.edu	37	13	41814411	41814411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:41814411G>A	ENST00000379480.4	-	6	956	c.856C>T	c.(856-858)Cct>Tct	p.P286S	MTRF1_ENST00000430347.2_Missense_Mutation_p.P299S|MTRF1_ENST00000379477.1_Missense_Mutation_p.P286S	NM_004294.2	NP_004285.2	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	286					regulation of translational termination	mitochondrion	translation release factor activity, codon specific			breast(1)|endometrium(4)|large_intestine(3)|lung(6)	14		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		TCTGGCTGAGGAAGGACAATA	0.532000													35	110					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28540967	28540967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28540967G>A	ENST00000452236.2	-	4	3316	c.2699C>T	c.(2698-2700)tCa>tTa	p.S900L		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	900					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						aagttgcaatgaaaaatactt	0.333000													19	61					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841080	13841080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13841080C>T	ENST00000265104.4	-	34	5748	c.5644G>A	c.(5644-5646)Gaa>Aaa	p.E1882K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1882	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTCACTCGTTCCGTGGAACTC	0.398000									Kartagener syndrome				17	84					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179583227	179583227	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179583227C>T	ENST00000589042.1	-	85	24830	c.24606G>A	c.(24604-24606)gtG>gtA	p.V8202V	TTN_ENST00000342992.6_Silent_p.V6958V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.V7885V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7885	Ig-like 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTATCCAGCTCACTGAGATTG	0.428000													8	58					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149882491	149882491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149882491G>A	ENST00000369146.3	-	4	1332	c.842C>T	c.(841-843)tCc>tTc	p.S281F	SV2A_ENST00000369145.1_Missense_Mutation_p.S281F	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	281					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CAGAAACTCGGAGAAATAGGA	0.527000													7	58					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032408	30032408	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30032408C>T	ENST00000328224.6	-	2	3051	c.1818G>A	c.(1816-1818)ggG>ggA	p.G606G		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	606						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CTGACTTGTCCCCCAGGGAAG	0.468000													29	57					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926258	70926258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70926258G>A	ENST00000603540.1	+	2	2300	c.2042G>A	c.(2041-2043)gGa>gAa	p.G681E	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Missense_Mutation_p.G681E	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	681					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCAAAGAGAGGAGTTTTTTTG	0.488000													23	34					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58231851	58231851	+	Nonstop_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58231851A>T	ENST00000317398.6	-	4	1698	c.1603T>A	c.(1603-1605)Taa>Aaa	p.*535K	AC003006.7_ENST00000599221.1_Intron|ZNF671_ENST00000335820.3_Nonstop_Mutation_p.*437K	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTACACTCTTAAAGCTTTTCT	0.483000													224	394					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74452068	74452068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74452068C>T	ENST00000394019.2	-	28	3542	c.3145G>A	c.(3145-3147)Gac>Aac	p.D1049N	SLC4A5_ENST00000346834.4_Missense_Mutation_p.D968N|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Missense_Mutation_p.D968N|SLC4A5_ENST00000377634.4_Missense_Mutation_p.D1065N|SLC4A5_ENST00000359484.4_Missense_Mutation_p.D947N|SLC4A5_ENST00000357822.5_Missense_Mutation_p.D1065N|SLC4A5_ENST00000358683.4_Missense_Mutation_p.D947N|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Missense_Mutation_p.R989Q	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1065						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CAGGCCAGGTCGTGCTGGGAA	0.473000													28	81					0	0	1	0	0
SIGLEC14	100049587	broad.mit.edu	37	19	52146630	52146630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52146630C>T	ENST00000360844.6	-	7	1210	c.1169G>A	c.(1168-1170)aGc>aAc	p.S390N	SIGLEC5_ENST00000429354.3_Intron|SIGLEC5_ENST00000534261.2_Intron|SIGLEC5_ENST00000599649.1_Intron|SIGLEC5_ENST00000222107.4_Intron	NM_001098612.1	NP_001092082.1	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14	390					cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		CTCAGCCCTGCTCTGCTGGGG	0.607000													6	62					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140189125	140189125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140189125C>T	ENST00000530339.1	+	1	2353	c.2353C>T	c.(2353-2355)Cag>Tag	p.Q785*	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Nonsense_Mutation_p.Q785*|PCDHA4_ENST00000512229.2_Nonsense_Mutation_p.Q785*|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGAGAAGATCAGCTGCAGAC	0.468000													16	170					0	0	1	0	0
IFI27	3429	broad.mit.edu	37	14	94578046	94578046	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94578046C>T	ENST00000555744.1	+	2	206	c.18C>T	c.(16-18)ctC>ctT	p.L6L	IFI27_ENST00000444961.1_Silent_p.L6L|IFI27_ENST00000557634.1_Silent_p.L6L|IFI27_ENST00000557098.1_Intron|IFI27_ENST00000298902.5_Silent_p.L6L|IFI27_ENST00000448882.1_Silent_p.L6L			P40305	IFI27_HUMAN	interferon, alpha-inducible protein 27	6					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion				breast(1)|lung(3)	4				Epithelial(152;0.112)|all cancers(159;0.187)|COAD - Colon adenocarcinoma(157;0.206)		CCTCTGCTCTCACCTCATCAG	0.597000													11	74					0	0	1	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3395114	3395114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3395114G>A	ENST00000378378.4	+	12	2157	c.1752G>A	c.(1750-1752)caG>caA	p.Q584Q	ARHGEF16_ENST00000413250.2_Silent_p.Q288Q|ARHGEF16_ENST00000378371.2_Silent_p.Q296Q|ARHGEF16_ENST00000378373.1_Silent_p.Q296Q	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	584	PH.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		ACCCCTTCCAGGTGACCCTGC	0.672000													34	60					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233393	21233393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21233393C>T	ENST00000233242.1	-	26	6474	c.6347G>A	c.(6346-6348)gGa>gAa	p.G2116E		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2116	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGGAGTTTTCCCAGGGCTGC	0.383000													17	44					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086661	39086661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39086661C>T	ENST00000400482.3	-	3	1388	c.799G>A	c.(799-801)Ggg>Agg	p.G267R	KCNJ6_ENST00000288309.6_Missense_Mutation_p.G267R	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	267					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CGGTCATCCCCCGTGTAATAC	0.507000													46	98					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41748899	41748899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41748899G>A	ENST00000301178.4	+	11	1614	c.1424G>A	c.(1423-1425)cGa>cAa	p.R475Q	AXL_ENST00000593513.1_Missense_Mutation_p.R207Q|AXL_ENST00000359092.3_Missense_Mutation_p.R466Q	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	475						integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GTCCACCGGCGAAAGAAGGAG	0.607000													19	53					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90025464	90025464	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90025464C>T	ENST00000405460.2	+	50	10528	c.10432C>T	c.(10432-10434)Cag>Tag	p.Q3478*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3478					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGCAGGAGATCAGAATTCAAT	0.303000													5	21					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982673	36982673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36982673G>A	ENST00000274963.8	+	8	1059	c.888G>A	c.(886-888)cgG>cgA	p.R296R		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	296					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						CCTAGGAGCGGCTGCAGGACC	0.642000													17	48					0	0	1	0	0
TLE2	7089	broad.mit.edu	37	19	3005791	3005791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3005791G>A	ENST00000262953.6	-	16	1938	c.1676C>T	c.(1675-1677)gCc>gTc	p.A559V	TLE2_ENST00000426948.2_Missense_Mutation_p.A573V|TLE2_ENST00000443826.3_Missense_Mutation_p.A437V|TLE2_ENST00000586422.1_Intron|TLE2_ENST00000447365.2_Missense_Mutation_p.A226V|TLE2_ENST00000591529.1_Missense_Mutation_p.A573V|TLE2_ENST00000590536.1_Missense_Mutation_p.A560V|TLE2_ENST00000455444.2_Missense_Mutation_p.A437V	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	559					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAAACCTTGGCGTCGGGGCT	0.637000													7	59					0	0	1	0	0
POC5	134359	broad.mit.edu	37	5	75008689	75008689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75008689G>A	ENST00000428202.2	-	2	263	c.74C>T	c.(73-75)tCg>tTg	p.S25L	POC5_ENST00000514838.2_Missense_Mutation_p.S25L|POC5_ENST00000380475.2_5'UTR	NM_001099271.1	NP_001092741.1	Q8NA72	POC5_HUMAN	POC5 centriolar protein	25					cell cycle	centriole				breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CTGAAGATTCGAAGAGACAGA	0.323000													5	19					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759682	6759682	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6759682G>A	ENST00000378827.4	+	3	2356	c.1137G>A	c.(1135-1137)aaG>aaA	p.K379K		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	379					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	AGAATGAAAAGGTTGTATTAA	0.373000													19	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179476172	179476172	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179476172C>T	ENST00000589042.1	-	269	51008	c.50784G>A	c.(50782-50784)gtG>gtA	p.V16928V	TTN_ENST00000342992.6_Silent_p.V14360V|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Silent_p.V7863V|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.V8055V|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Silent_p.V7988V|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.V15287V|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15287	Fibronectin type-III 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGACTGCTCTCACTCTCAGGA	0.418000													18	88					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347850	91347850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91347850C>T	ENST00000358859.2	-	1	1103	c.670G>A	c.(670-672)Gag>Aag	p.E224K	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		GGGGAGGCCTCGCCGCTCACC	0.622000													47	170					0	0	1	0	0
LACC1	144811	broad.mit.edu	37	13	44464388	44464388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:44464388C>T	ENST00000441843.1	+	6	1757	c.1272C>T	c.(1270-1272)ggC>ggT	p.G424G	LACC1_ENST00000325686.6_Silent_p.G424G	NM_001128303.1	NP_001121775.1	Q8IV20	CM031_HUMAN	laccase (multicopper oxidoreductase) domain containing 1	424																	CACAGATTGGCTTCATATCAA	0.438000													20	64					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104895	183104895	+	Missense_Mutation	SNP	C	C	T	rs145482728		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:183104895C>T	ENST00000435564.1	-	3	540	c.340G>A	c.(340-342)Gaa>Aaa	p.E114K	PDE1A_ENST00000346717.4_Missense_Mutation_p.E80K|PDE1A_ENST00000358139.2_Missense_Mutation_p.E114K|PDE1A_ENST00000331935.6_Missense_Mutation_p.E114K|PDE1A_ENST00000456212.1_Missense_Mutation_p.E114K|PDE1A_ENST00000536095.1_Missense_Mutation_p.E10K|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Missense_Mutation_p.E114K|PDE1A_ENST00000409365.1_Missense_Mutation_p.E98K|PDE1A_ENST00000351439.5_Missense_Mutation_p.E98K	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	114					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.E114K(1)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTTGGTTTTTCCTCAGGTTTC	0.418000													31	111					0	0	1	0	0
STK26	51765	broad.mit.edu	37	X	131202542	131202542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:131202542G>A	ENST00000394334.2	+	6	795	c.542G>A	c.(541-543)gGa>gAa	p.G181E	MST4_ENST00000354719.6_Missense_Mutation_p.G181E|MST4_ENST00000481105.1_Missense_Mutation_p.G203E|MST4_ENST00000394335.2_Missense_Mutation_p.G104E|MST4_ENST00000496850.1_Missense_Mutation_p.G181E	NM_016542.3	NP_057626.2	Q9P289	MST4_HUMAN		181	Protein kinase.				cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(192;0.000127)					ACCTTTGTGGGAACTCCATTT	0.378000													31	53					0	0	1	0	0
BABAM1	29086	broad.mit.edu	37	19	17382414	17382414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17382414C>T	ENST00000359435.4	+	3	487	c.294C>T	c.(292-294)tgC>tgT	p.C98C	BABAM1_ENST00000601043.1_Silent_p.C98C|BABAM1_ENST00000595632.1_Silent_p.C98C|BABAM1_ENST00000448635.2_3'UTR|BABAM1_ENST00000447614.2_Silent_p.C98C|BABAM1_ENST00000598188.1_Silent_p.C98C|CTD-2278I10.6_ENST00000596542.1_Intron	NM_001033549.1	NP_001028721.1	Q9NWV8	BABA1_HUMAN	BRISC and BRCA1 A complex member 1	98	VWFA-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|protein K63-linked deubiquitination|response to ionizing radiation	BRCA1-A complex|BRISC complex|cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5						AGATTATCTGCCTGGACCTGT	0.547000													9	21					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117609777	117609777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117609777C>T	ENST00000368508.3	-	43	7120	c.6922G>A	c.(6922-6924)Gaa>Aaa	p.E2308K	ROS1_ENST00000368507.3_Missense_Mutation_p.E2302K	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2308					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.E2308Q(2)	TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCATGTGGTTCCTTCTCTTCT	0.483000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								28	34					0	0	1	0	0
TSPAN12	23554	broad.mit.edu	37	7	120428804	120428804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120428804C>T	ENST00000222747.3	-	8	1367	c.760G>A	c.(760-762)Gag>Aag	p.E254K	TSPAN12_ENST00000415871.1_Missense_Mutation_p.E254K	NM_012338.3	NP_036470.1	O95859	TSN12_HUMAN	tetraspanin 12	254					angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction				endometrium(3)|kidney(1)|lung(4)|ovary(1)|skin(1)	10	all_neural(327;0.117)					GTCCCCGGCTCCCTTCTATCA	0.483000													29	81					0	0	1	0	0
GSX2	170825	broad.mit.edu	37	4	54966673	54966673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:54966673G>A	ENST00000326902.2	+	1	476	c.162G>A	c.(160-162)aaG>aaA	p.K54K	FIP1L1_ENST00000507166.1_Intron|GSX2_ENST00000503800.1_Silent_p.K54K	NM_133267.2	NP_573574.1	Q9BZM3	GSX2_HUMAN	GS homeobox 2	54						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(2)|lung(2)	6	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			CGTCCCGCAAGAGCGGCGCGT	0.716000													12	20					0	0	1	0	0
AGBL2	79841	broad.mit.edu	37	11	47721096	47721096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47721096G>A	ENST00000525123.1	-	8	881	c.596C>T	c.(595-597)cCa>cTa	p.P199L	AGBL2_ENST00000529712.1_5'UTR|AGBL2_ENST00000528244.1_Missense_Mutation_p.P161L|AGBL2_ENST00000357610.3_Missense_Mutation_p.P199L|AGBL2_ENST00000298861.4_Missense_Mutation_p.P199L	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	199					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						TGGTTGAGGTGGAGCCCACTC	0.303000													17	34					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316279	30316279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30316279C>T	ENST00000375377.1	-	3	2899	c.2798G>A	c.(2797-2799)gGc>gAc	p.G933D		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	933										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						GCGAAAGCGGCCCGGGGATGG	0.607000													10	72					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234106900	234106900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234106900C>T	ENST00000359570.5	+	27	2817	c.2817C>T	c.(2815-2817)tcC>tcT	p.S939S	INPP5D_ENST00000455936.2_Silent_p.S703S|INPP5D_ENST00000450745.1_Silent_p.S703S			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	951	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CCAAGGACTCCCCGCTGGGGC	0.647000													19	59					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164271863	164271863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164271863C>T	ENST00000515560.1	+	4	1960	c.438C>T	c.(436-438)ccC>ccT	p.P146P	NPY5R_ENST00000506953.1_Silent_p.P146P|NPY5R_ENST00000338566.3_Silent_p.P146P			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	146					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				TAAAACATCCCATATCTAATA	0.363000													70	174					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179452474	179452474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179452474C>T	ENST00000589042.1	-	306	63786	c.63562G>A	c.(63562-63564)Gca>Aca	p.A21188T	TTN_ENST00000342992.6_Missense_Mutation_p.A18620T|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.A12123T|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.A12315T|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.A12248T|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.A19547T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19547	Fibronectin type-III 53.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCATCCTGCTCTCACTATG	0.443000													12	36					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20140998	20140998	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20140998G>A	ENST00000375121.2	-	1	773	c.597C>T	c.(595-597)ctC>ctT	p.L199L	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	199						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGGTGCTGGGGAGACAGCAGA	0.592000													9	44					0	0	1	0	0
XKR8	55113	broad.mit.edu	37	1	28290032	28290032	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28290032G>A	ENST00000373884.5	+	2	926	c.318G>A	c.(316-318)ggG>ggA	p.G106G		NM_018053.2	NP_060523.2	Q9H6D3	XKR8_HUMAN	XK, Kell blood group complex subunit-related family, member 8	106						integral to membrane				endometrium(1)|large_intestine(2)|lung(1)	4		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;4.72e-24)|Colorectal(126;1.52e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00572)|READ - Rectum adenocarcinoma(331;0.0526)		TGCGGCAGGGGCTGCTGGTGT	0.602000													17	40					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26096140	26096140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26096140G>A	ENST00000313735.6	-	17	2130	c.1897C>T	c.(1897-1899)Cgg>Tgg	p.R633W		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	633	Flavodoxin-like.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GCGCAGAACCGAGGGTACATG	0.607000													4	22					0	0	1	0	0
SOX7	83595	broad.mit.edu	37	8	10583561	10583561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10583561G>A	ENST00000304501.1	-	2	932	c.854C>T	c.(853-855)tCc>tTc	p.S285F	SOX7_ENST00000554914.1_Missense_Mutation_p.S337F|SOX7_ENST00000553390.1_Missense_Mutation_p.S337F	NM_031439.2	NP_113627.1	Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	285	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding	p.S285F(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		GGTGGCCGGGGAGTAATAGGC	0.667000													15	29					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43045247	43045247	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43045247G>A	ENST00000267890.6	-	14	2305	c.2197C>T	c.(2197-2199)Cag>Tag	p.Q733*		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	733					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TGATCTATCTGAAGCCCCAAA	0.448000													18	204					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519762	69519762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69519762C>T	ENST00000338206.5	-	5	1315	c.1306G>A	c.(1306-1308)Gac>Aac	p.D436N		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	436					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CACACAGGGTCATTAATGACT	0.373000													69	165					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215852476	215852476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215852476G>A	ENST00000272895.7	-	27	4090	c.3871C>T	c.(3871-3873)Cct>Tct	p.P1291S	ABCA12_ENST00000389661.4_Missense_Mutation_p.P973S	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1291					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CAATAGGAAGGAAGAATTGGA	0.423000													6	33					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121356037	121356037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121356037C>T	ENST00000314583.3	-	7	612	c.521G>A	c.(520-522)gGa>gAa	p.G174E	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Intron	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	174					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		GTAGTCATATCCCAGAGCTGC	0.552000													7	122					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516601	140516601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140516601C>T	ENST00000231134.5	+	1	1802	c.1585C>T	c.(1585-1587)Cgc>Tgc	p.R529C		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		529	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding	p.R529C(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGAGTTCCGCGTGGGAGC	0.682000													55	88					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78380231	78380231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78380231C>T	ENST00000278550.7	-	32	7621	c.7159G>A	c.(7159-7161)Gag>Aag	p.E2387K		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		ATGTAGATCTCCCCATAGGCT	0.483000													4	32					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37903043	37903043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37903043G>A	ENST00000199447.4	+	8	805	c.433G>A	c.(433-435)Gaa>Aaa	p.E145K	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.E145K	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	145					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										AGTTAGTGAAGAATCACCATG	0.343000													24	105					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60193679	60193679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:60193679G>A	ENST00000267484.5	-	3	2058	c.1723C>T	c.(1723-1725)Cct>Tct	p.P575S		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	575					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GGGGCGCCAGGACCTAGAGGC	0.587000													12	12					0	0	1	0	0
POLR1E	64425	broad.mit.edu	37	9	37486584	37486584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37486584C>T	ENST00000377792.3	+	1	435	c.147C>T	c.(145-147)ttC>ttT	p.F49F	POLR1E_ENST00000377798.4_Intron|POLR1E_ENST00000442009.2_Intron			Q9GZS1	RPA49_HUMAN	polymerase (RNA) I polypeptide E, 53kDa	49					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding			autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|skin(1)|stomach(1)	12				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		ACCCGAGCTTCCTTGCCATCC	0.582000													11	11					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155018608	155018608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155018608G>A	ENST00000295542.1	+	12	1376	c.1280G>A	c.(1279-1281)cGg>cAg	p.R427Q	DCST1_ENST00000392480.1_Missense_Mutation_p.R427Q|DCST1_ENST00000368419.2_Missense_Mutation_p.R427Q|DCST1_ENST00000423025.2_Missense_Mutation_p.R402Q	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	427						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CAGGGCAAACGGACTCTGCTG	0.557000													22	74					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3888393	3888393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3888393G>A	ENST00000319331.3	+	2	2829	c.2068G>A	c.(2068-2070)Ggt>Agt	p.G690S	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	690						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCTCTGGGAAGGTGACAGCGA	0.423000													25	38					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176833426	176833426	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176833426C>T	ENST00000367654.2	-	23	3916	c.3903G>A	c.(3901-3903)gaG>gaA	p.E1301E	ASTN1_ENST00000367657.3_Intron|ASTN1_ENST00000361833.2_Silent_p.E1293E			O14525	ASTN1_HUMAN	astrotactin 1	1301					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GGTGCTAGATCTCTTTGCTGT	0.517000													60	131					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3047596	3047596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3047596C>T	ENST00000520002.1	-	35	5794	c.5239G>A	c.(5239-5241)Gag>Aag	p.E1747K	CSMD1_ENST00000542608.1_Missense_Mutation_p.E1746K|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000539096.1_Missense_Mutation_p.E1746K|CSMD1_ENST00000537824.1_Missense_Mutation_p.E1746K|CSMD1_ENST00000602723.1_Missense_Mutation_p.E1747K|CSMD1_ENST00000400186.3_Missense_Mutation_p.E1747K|CSMD1_ENST00000602557.1_Missense_Mutation_p.E1747K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1747	Sushi 10.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TATCTGGGCTCGGGGACAGAG	0.557000													4	6					0	0	1	0	0
IFNA17	3451	broad.mit.edu	37	9	21227932	21227932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21227932G>A	ENST00000413767.2	-	1	289	c.241C>T	c.(241-243)Cat>Tat	p.H81Y		NM_021268.2	NP_067091.1	P01571	IFN17_HUMAN	interferon, alpha 17	81					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(2)|lung(4)|ovary(1)|skin(1)	9				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		ATCATCTCATGGAGGACAGAG	0.488000													51	111					0	0	1	0	0
SPATA4	132851	broad.mit.edu	37	4	177114160	177114160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:177114160C>T	ENST00000280191.2	-	3	524	c.416G>A	c.(415-417)gGa>gAa	p.G139E	SPATA4_ENST00000515234.1_5'UTR	NM_144644.2	NP_653245.2	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	139					apoptosis|spermatogenesis					NS(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)	22		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		TTCAGGCACTCCAGCTTTACA	0.284000													17	38					0	0	1	0	0
ATXN7	6314	broad.mit.edu	37	3	63967960	63967960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:63967960C>T	ENST00000398590.3	+	7	1404	c.851C>T	c.(850-852)tCc>tTc	p.S284F	ATXN7_ENST00000487717.1_Missense_Mutation_p.S284F|ATXN7_ENST00000538065.1_Missense_Mutation_p.S284F|ATXN7_ENST00000295900.6_Missense_Mutation_p.S284F|ATXN7_ENST00000484332.1_Missense_Mutation_p.S139F|ATXN7_ENST00000488239.1_3'UTR	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	284					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		ACTGTGAGTTCCTTAGTCAAG	0.517000													9	66					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47423320	47423320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47423320C>T	ENST00000361866.3	+	35	2594	c.2480C>T	c.(2479-2481)cCg>cTg	p.P827L	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	827	C-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	TTCTCCTCCCCGGCTGACATC	0.677000													7	62					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50366976	50366976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50366976G>A	ENST00000315520.5	+	1	357	c.20G>A	c.(19-21)gGg>gAg	p.G7E	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	7					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						GTGGAGCCAGGGGGACGTGGC	0.592000													8	43					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202400940	202400940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202400940G>A	ENST00000439140.1	-	13	1354	c.1310C>T	c.(1309-1311)cCt>cTt	p.P437L	ALS2CR11_ENST00000450242.1_Missense_Mutation_p.P437L|ALS2CR11_ENST00000439802.1_Intron|ALS2CR11_ENST00000286195.3_Missense_Mutation_p.P437L	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	437										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						TGTGGGTGAAGGTGTTGATTC	0.403000													58	114					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75036941	75036941	+	Missense_Mutation	SNP	C	C	T	rs139857791	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75036941C>T	ENST00000326665.5	-	14	4671	c.4453G>A	c.(4453-4455)Gaa>Aaa	p.E1485K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1485	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGACTCAATTCCCTCTCTCCC	0.542000													69	157					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167060583	167060583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167060583C>T	ENST00000375387.4	-	26	4999	c.4659G>A	c.(4657-4659)gtG>gtA	p.V1553V	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Silent_p.V1541V|SCN9A_ENST00000409435.1_Silent_p.V1552V|SCN9A_ENST00000303354.6_Silent_p.V1553V			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1552						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTATAAAAACCACATTTATCC	0.353000													5	57					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419919	130419919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130419919C>T	ENST00000370904.1	-	10	1084	c.174G>A	c.(172-174)aaG>aaA	p.K58K	IGSF1_ENST00000370903.3_Silent_p.K67K|IGSF1_ENST00000370901.4_Silent_p.K67K|IGSF1_ENST00000370910.1_Silent_p.K58K|IGSF1_ENST00000370900.1_Silent_p.K67K|IGSF1_ENST00000361420.3_Silent_p.K67K			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	67	Ig-like C2-type 1.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GCAGCAGGAACTTGCTTGATA	0.527000													48	55					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101344485	101344485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101344485G>A	ENST00000344327.3	-	7	2188	c.1764C>T	c.(1762-1764)ccC>ccT	p.P588P	TRPC6_ENST00000532133.1_Silent_p.P510P|TRPC6_ENST00000360497.4_Silent_p.P533P|TRPC6_ENST00000348423.4_Silent_p.P472P	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	588					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GAGGATCAGAGGGGTCCCACT	0.348000													54	98					0	0	1	0	0
ALPP	250	broad.mit.edu	37	2	233244485	233244485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233244485G>A	ENST00000392027.2	+	5	765	c.496G>A	c.(496-498)Gga>Aga	p.G166R	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	166						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GAAGTCAGTGGGAGTGGTAAC	0.632000													15	42					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79033081	79033081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79033081G>A	ENST00000446378.2	+	2	8524	c.8493G>A	c.(8491-8493)gtG>gtA	p.V2831V		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2831						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTAACGCAGTGAAGAAAAAAG	0.398000													18	44					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115829395	115829395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115829395G>A	ENST00000369512.2	-	3	190	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	8					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	GCTGTGATCAGAGTGTAGAAC	0.478000													34	80					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401432	77401432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77401432G>A	ENST00000282849.5	-	4	1102	c.684C>T	c.(682-684)tcC>tcT	p.S228S	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	228					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGTGACTTGGGGAGTAACCAG	0.517000													22	52					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34021740	34021740	+	Silent	SNP	C	C	T	rs146951838		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34021740C>T	ENST00000374372.1	-	4	1976	c.1473G>A	c.(1471-1473)gaG>gaA	p.E491E	GDF5OS_ENST00000374375.1_5'UTR|GDF5_ENST00000374369.3_Silent_p.E491E			P43026	GDF5_HUMAN	growth differentiation factor 5	491			E -> K (in SYM1).		cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CGACCATGTCCTCATACTGCT	0.587000													35	69					0	0	1	0	0
LDHD	197257	broad.mit.edu	37	16	75146541	75146541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:75146541C>T	ENST00000300051.4	-	10	1363	c.1317G>A	c.(1315-1317)gaG>gaA	p.E439E	LDHD_ENST00000450168.2_Silent_p.E416E	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	439							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding			endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						TGCCCAGTTCCTCGGCGTCAT	0.607000													16	36					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28861653	28861653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28861653C>T	ENST00000373833.6	+	8	818	c.533C>T	c.(532-534)gCc>gTc	p.A178V	RCC1_ENST00000429051.1_3'UTR|RCC1_ENST00000373831.3_Missense_Mutation_p.A209V|RCC1_ENST00000373832.1_Missense_Mutation_p.A178V|RCC1_ENST00000398958.2_Missense_Mutation_p.A178V			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	178					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GTAAAGGTGGCCTCAGGTGGG	0.582000													17	73					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154411258	154411258	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:154411258C>T	ENST00000414028.2	+	2	638	c.588C>T	c.(586-588)ctC>ctT	p.L196L	OPRM1_ENST00000419506.2_Silent_p.L196L|OPRM1_ENST00000452687.2_Silent_p.L196L|OPRM1_ENST00000435918.2_Silent_p.L196L|OPRM1_ENST00000434900.2_Silent_p.L289L|OPRM1_ENST00000428397.2_Silent_p.L196L|OPRM1_ENST00000520708.1_Silent_p.L96L|OPRM1_ENST00000229768.5_Silent_p.L196L|OPRM1_ENST00000522236.1_Silent_p.L96L|OPRM1_ENST00000518759.1_Silent_p.L115L|OPRM1_ENST00000330432.7_Silent_p.L196L|OPRM1_ENST00000524163.1_Silent_p.L196L|OPRM1_ENST00000360422.4_Silent_p.L196L|OPRM1_ENST00000337049.4_Silent_p.L196L|OPRM1_ENST00000522555.1_Silent_p.L96L	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	196					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	ACTGGATCCTCTCTTCAGCCA	0.473000													46	60					0	0	1	0	0
OTOR	56914	broad.mit.edu	37	20	16730641	16730641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:16730641G>A	ENST00000246081.2	+	3	393	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K	OTOR_ENST00000486129.1_3'UTR	NM_020157.2	NP_064542.1	Q9NRC9	OTOR_HUMAN	otoraplin	117					sensory perception of sound	extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|liver(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10						AGCTACCAAGGAAGTTCCCAC	0.488000													12	31					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18725187	18725187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18725187C>T	ENST00000440756.2	-	4	1733	c.1631G>A	c.(1630-1632)gGa>gAa	p.G544E	PSD3_ENST00000327040.8_Missense_Mutation_p.G544E|PSD3_ENST00000523619.1_Missense_Mutation_p.G479E			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	544	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CGAGTACCTTCCCCAGAAAGC	0.463000													19	51					0	0	1	0	0
LOC401127	401127	broad.mit.edu	37	4	39482942	39482942	+	RNA	SNP	A	A	C	rs10010309	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39482942A>C	ENST00000513652.1	+	0	949																											ACATCTGGAAACTTCAGACGA	0.453000													6	71					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106968913	106968913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:106968913C>T	ENST00000369066.3	+	2	3093	c.2606C>T	c.(2605-2607)tCc>tTc	p.S869F		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	869							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CAGAACGGTTCCCTATCTCAG	0.463000													34	58					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52842628	52842628	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52842628C>T	ENST00000449956.2	+	22	2610	c.2604C>T	c.(2602-2604)ttC>ttT	p.F868F	ITIH3_ENST00000416872.2_Silent_p.F676F	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	868					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TCTGCTGGTTCGTCCACAACA	0.532000													10	34					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386213	56386213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56386213G>A	ENST00000355701.3	-	22	5290	c.4420C>T	c.(4420-4422)Cgg>Tgg	p.R1474W	BZRAP1_ENST00000268893.6_Missense_Mutation_p.R1414W|BZRAP1_ENST00000343736.4_Missense_Mutation_p.R1474W	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1474						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGCACCTCCGGGAAGGGCCC	0.657000													13	26					0	0	1	0	0
HIATL1	84641	broad.mit.edu	37	9	97218585	97218585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:97218585C>T	ENST00000375344.3	+	10	1361	c.1092C>T	c.(1090-1092)gcC>gcT	p.A364A	HIATL1_ENST00000428393.2_Intron	NM_032558.2	NP_115947.2	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	364					transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	11		Acute lymphoblastic leukemia(62;0.136)				CAATCAGTGCCCTCGTCTCTC	0.582000													21	64					0	0	1	0	0
TOP2B	7155	broad.mit.edu	37	3	25674066	25674066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:25674066G>A	ENST00000435706.2	-	10	1323	c.1122C>T	c.(1120-1122)aaC>aaT	p.N374N	TOP2B_ENST00000264331.4_Silent_p.N379N			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa	379					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						CCCATATATGGTTTTTTACCT	0.299000													7	21					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45518302	45518302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45518302C>T	ENST00000291574.4	+	21	3408	c.3233C>T	c.(3232-3234)tCc>tTc	p.S1078F		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1078					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						AGAACAGGCTCCCTCTGCTCC	0.473000													56	159					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674183	4674183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4674183C>T	ENST00000396952.5	+	2	1077	c.427C>T	c.(427-429)Cgt>Tgt	p.R143C	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TACGTTGCCTCGTGTCACCAA	0.567000													33	72					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004702	52004702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52004702G>A	ENST00000291707.3	-	1	341	c.286C>T	c.(286-288)Ctt>Ttt	p.L96F		NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	96	Ig-like V-type 1.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGGTCCCCAAGGAGGTGGAAT	0.542000													39	161					0	0	1	0	0
ZNF8	7554	broad.mit.edu	37	19	58805736	58805736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58805736C>T	ENST00000196548.5	+	4	693	c.562C>T	c.(562-564)Cca>Tca	p.P188S	AC010642.1_ENST00000591325.1_3'UTR	NM_021089.2	NP_066575.2	P17098	ZNF8_HUMAN	zinc finger protein 8	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	19		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		GAGTTCAAGCCCAAATCCATT	0.448000													22	40					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3076448	3076448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3076448C>T	ENST00000397461.1	+	16	2300	c.1916C>T	c.(1915-1917)tCc>tTc	p.S639F	CNTN4_ENST00000418658.1_Missense_Mutation_p.S639F|CNTN4_ENST00000448906.2_Missense_Mutation_p.S311F|CNTN4_ENST00000358480.3_Missense_Mutation_p.S420F|CNTN4_ENST00000397459.2_Missense_Mutation_p.S311F|CNTN4_ENST00000427331.1_Missense_Mutation_p.S639F	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	639	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ACTCCATTCTCCGTGGGCTGG	0.537000													26	78					0	0	1	0	0
TRAV4	28689	broad.mit.edu	37	14	22204515	22204515	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22204515G>A	ENST00000390426.2	+	0	82																											GGCAAGTGGCGAGAGTGATCG	0.522000													5	11					0	0	1	0	0
CPA5	93979	broad.mit.edu	37	7	130007814	130007814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:130007814G>A	ENST00000485477.1	+	11	2235	c.1106G>A	c.(1105-1107)aGc>aAc	p.S369N	CPA5_ENST00000431780.2_Intron|CPA5_ENST00000474905.1_Missense_Mutation_p.S369N|CPA5_ENST00000355388.3_Missense_Mutation_p.S369N|CPA5_ENST00000461828.1_Missense_Mutation_p.S369N|CPA5_ENST00000393213.3_Missense_Mutation_p.S369N|CPA5_ENST00000466363.2_Missense_Mutation_p.S369N			Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5	369					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(2)|breast(2)|endometrium(2)|large_intestine(7)|lung(4)|ovary(3)|pancreas(1)|skin(2)	23	Melanoma(18;0.0435)					ATTTTTGGCAGCATCAGCACC	0.572000													20	53					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44843419	44843419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44843419C>T	ENST00000326047.4	+	13	1611	c.1462C>T	c.(1462-1464)Cgt>Tgt	p.R488C	KIF15_ENST00000425755.1_Missense_Mutation_p.R123C	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	488					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GGAGCAGGATCGTTTGCTCTC	0.378000													13	34					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86697680	86697680	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86697680G>A	ENST00000441037.2	+	3	239	c.144G>A	c.(142-144)aaG>aaA	p.K48K	AGBL1_ENST00000421325.2_Silent_p.K48K	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	48					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TTGGACGGAAGGCCCTAGAAT	0.448000													10	18					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68707096	68707096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68707096C>T	ENST00000255078.3	+	15	2990	c.2879C>T	c.(2878-2880)tCc>tTc	p.S960F		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	960					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding	p.S960F(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AAGAACGGATCCCTGGACCCA	0.657000													5	30					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21689995	21689995	+	Missense_Mutation	SNP	C	C	T	rs142656537	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21689995C>T	ENST00000261195.2	-	16	2259	c.2005G>A	c.(2005-2007)Gat>Aat	p.D669N		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	669					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TCTTCCTCATCGTATCTCTCA	0.483000													22	86					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8376633	8376633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8376633C>T	ENST00000538603.1	-	5	860	c.302G>A	c.(301-303)gGa>gAa	p.G101E	FAM90A1_ENST00000307435.6_Missense_Mutation_p.G101E	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	101							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		TTCCTTCTCTCCCTTATCCTT	0.537000													58	143					0	0	1	0	0
RBM23	55147	broad.mit.edu	37	14	23380554	23380554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23380554G>A	ENST00000359890.3	-	2	244	c.49C>T	c.(49-51)Ccc>Tcc	p.P17S	RBM23_ENST00000346528.5_Missense_Mutation_p.P17S|RBM23_ENST00000542016.2_5'UTR|RBM23_ENST00000399922.2_Missense_Mutation_p.P17S|RBM23_ENST00000556984.1_5'UTR|RBM23_ENST00000555209.1_Intron	NM_001077351.1	NP_001070819.1	Q86U06	RBM23_HUMAN	RNA binding motif protein 23	17					mRNA processing	nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|lung(3)|prostate(1)|skin(1)	10	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		TTTTTATAGGGAGCTTCCAGC	0.368000													49	207					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075259	76075259	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:76075259G>A	ENST00000395215.3	+	0	899																											GAGTTTGGAGGGAAAGCTCCA	0.577000													35	101					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735371	140735371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140735371C>T	ENST00000571252.1	+	1	604	c.604C>T	c.(604-606)Cgc>Tgc	p.R202C	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTCTAGATCGCGAGGAAGA	0.557000													11	16					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21306909	21306909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21306909G>A	ENST00000602326.1	-	8	847	c.264C>T	c.(262-264)ccC>ccT	p.P88P	EIF4G3_ENST00000374937.3_Silent_p.P88P|EIF4G3_ENST00000356916.3_Silent_p.P92P|EIF4G3_ENST00000264211.8_Silent_p.P81P|EIF4G3_ENST00000374935.3_Silent_p.P81P|EIF4G3_ENST00000374927.4_Silent_p.P81P|EIF4G3_ENST00000400422.1_Silent_p.P81P	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	81					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		ATTGTTGGGGGGGCCCAACAT	0.433000													9	29					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10927488	10927488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:10927488C>T	ENST00000283141.6	+	17	1624	c.1328C>T	c.(1327-1329)tCc>tTc	p.S443F	RP11-637O19.3_ENST00000480294.1_Intron|SYCP2L_ENST00000543878.1_Intron	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	443						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GCAGAAGAATCCACTAACATG	0.448000													20	68					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784186	82784186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82784186G>A	ENST00000423517.2	-	2	2108	c.1771C>T	c.(1771-1773)Ctt>Ttt	p.L591F	PCLO_ENST00000333891.8_Missense_Mutation_p.L591F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	537	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTATTGCAAAGAGGACAGATG	0.453000													104	296					0	0	1	0	0
CACNG4	27092	broad.mit.edu	37	17	65026653	65026653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:65026653G>A	ENST00000262138.3	+	4	519	c.517G>A	c.(517-519)Gaa>Aaa	p.E173K		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	173					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			CAAGCGGGACGAAGACAAAAA	0.512000													43	110					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38925448	38925448	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38925448G>A	ENST00000274276.3	+	15	2589	c.2187G>A	c.(2185-2187)acG>acA	p.T729T		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	729	Fibronectin type-III 4.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					CTACGTTCACGAAGGTCACGA	0.433000													11	114					0	0	1	0	0
LCE2A	353139	broad.mit.edu	37	1	152671682	152671682	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152671682C>T	ENST00000368779.1	+	2	356	c.305C>T	c.(304-306)tCt>tTt	p.S102F		NM_178428.3	NP_848515.1	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	102	Cys-rich.				keratinization					breast(1)|large_intestine(1)|liver(2)|lung(4)	8	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCCACAGCTCTGGGGACTGC	0.602000													18	106					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24167407	24167407	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24167407G>A	ENST00000265769.4	+	3	261	c.150_splice	c.e3-1	p.E51_splice	ADAM28_ENST00000540823.1_5'UTR|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Splice_Site_p.E51_splice|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	51					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATTTTTGCAGGAACAATTTGA	0.234000													17	112					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12725985	12725985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12725985C>T	ENST00000376221.1	+	4	463	c.463C>T	c.(463-465)Cct>Tct	p.P155S		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	155						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		CCGCAAGCTTCCTGACCACCA	0.522000													22	80					0	0	1	0	0
SKA3	221150	broad.mit.edu	37	13	21732064	21732064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:21732064G>A	ENST00000314759.5	-	7	1240	c.1116C>T	c.(1114-1116)ctC>ctT	p.L372L	SKA3_ENST00000400018.3_Silent_p.L372L	NM_145061.5	NP_659498.4	Q8IX90	SKA3_HUMAN	spindle and kinetochore associated complex subunit 3	372					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						AAATAACCTGGAGAATATCTT	0.313000													19	56					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28906923	28906923	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28906923C>T	ENST00000257192.4	+	3	383	c.171C>T	c.(169-171)gcC>gcT	p.A57A		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	57	Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TCGCAGCAGCCTGTCGTGAAG	0.398000													24	99					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25121451	25121451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25121451C>T	ENST00000332271.5	-	17	2484	c.2068G>A	c.(2068-2070)Gga>Aga	p.G690R	PIWIL3_ENST00000533313.1_Missense_Mutation_p.G572R|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.G572R	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	690	Piwi.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						AGCTCTTCTCCTGTTTTCTGG	0.433000													9	137					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25341421	25341421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25341421G>A	ENST00000255324.5	+	2	194	c.142G>A	c.(142-144)Gaa>Aaa	p.E48K	RNF17_ENST00000255326.4_3'UTR|RNF17_ENST00000381921.1_Missense_Mutation_p.E48K|RNF17_ENST00000255325.5_Missense_Mutation_p.E48K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	48					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCACCATTGTGAACTTCAATG	0.358000													23	72					0	0	1	0	0
ZNF248	57209	broad.mit.edu	37	10	38127004	38127004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:38127004G>A	ENST00000395867.3	-	4	601	c.51C>T	c.(49-51)ttC>ttT	p.F17F	ZNF248_ENST00000357328.4_Silent_p.F17F|ZNF248_ENST00000494133.1_5'UTR|ZNF248_ENST00000374648.3_Silent_p.F17F	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						CTTCCTGAGTGAAGTCCACAC	0.383000													38	130					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150839020	150839020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150839020C>T	ENST00000397238.2	+	14	1840	c.1840C>T	c.(1840-1842)Ctc>Ttc	p.L614F	AGAP3_ENST00000463381.1_Missense_Mutation_p.L283F	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	578					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						GGTGGTGTCCCTCACTGGGCA	0.617000													8	94					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226026	158226026	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158226026C>T	ENST00000289429.5	+	3	1091	c.558C>T	c.(556-558)ttC>ttT	p.F186F		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	186	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GCCCACGTTTCATCTTGGGTC	0.463000													24	86					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156727806	156727806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156727806C>T	ENST00000347377.6	+	6	902	c.471C>T	c.(469-471)taC>taT	p.Y157Y	CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000377576.3_Silent_p.Y157Y|CYFIP2_ENST00000318218.6_Silent_p.Y157Y|CYFIP2_ENST00000541131.1_Silent_p.Y82Y|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000521420.1_Silent_p.Y131Y	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	157					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGAGGCCTACCTCCTGACCC	0.567000													13	25					0	0	1	0	0
CARS	833	broad.mit.edu	37	11	3040465	3040465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3040465G>A	ENST00000397114.3	-	12	1396	c.1020C>T	c.(1018-1020)gcC>gcT	p.A340A	CARS_ENST00000380525.4_Silent_p.A433A|CARS_ENST00000278224.9_Silent_p.A350A|CARS_ENST00000397111.5_Silent_p.A350A|CARS_ENST00000401769.3_Silent_p.A363A			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	350					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	TGCCTGCCATGGCCGAGCACT	0.597000			T	ALK	ALCL								34	128					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8421909	8421909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8421909G>A	ENST00000337907.3	-	18	2564	c.1930C>T	c.(1930-1932)Ctt>Ttt	p.L644F	RERE_ENST00000377464.1_Missense_Mutation_p.L376F|RERE_ENST00000476556.1_Missense_Mutation_p.L90F|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.L644F	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	644					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TTACTCTTAAGAGGGGAAGAG	0.552000													25	51					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899665	233899665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233899665C>T	ENST00000233840.3	+	2	1041	c.1041C>T	c.(1039-1041)tcC>tcT	p.S347S		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	347							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CTGATGGGTCCCCCTTGTTTG	0.587000													78	177					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314291	54314291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54314291C>T	ENST00000324134.6	-	3	790	c.622G>A	c.(622-624)Gag>Aag	p.E208K	NLRP12_ENST00000391772.1_Missense_Mutation_p.E208K|NLRP12_ENST00000535162.1_Missense_Mutation_p.E208K|NLRP12_ENST00000391773.1_Missense_Mutation_p.E208K|NLRP12_ENST00000354278.3_Missense_Mutation_p.E208K|NLRP12_ENST00000391775.3_Missense_Mutation_p.E208K|NLRP12_ENST00000351894.4_Missense_Mutation_p.E208K|NLRP12_ENST00000345770.5_Missense_Mutation_p.E208K	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	208					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CGCGGTGGCTCGGGGCGCTCC	0.647000													29	89					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234368445	234368445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234368445C>T	ENST00000264057.2	+	23	2749	c.2737C>T	c.(2737-2739)Cct>Tct	p.P913S	DGKD_ENST00000409813.3_Missense_Mutation_p.P869S	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	913					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	TGAGGGCGTGCCTGTGCAGGT	0.572000													19	33					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152193831	152193831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152193831C>T	ENST00000368801.2	-	3	349	c.274G>A	c.(274-276)Gat>Aat	p.D92N	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	92					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCAGTAATCTTTGCCAATG	0.413000													23	64					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21552453	21552453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:21552453G>A	ENST00000281523.2	-	4	857	c.339C>T	c.(337-339)gcC>gcT	p.A113A	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	113						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						TATTTTTCATGGCTTCCAGTG	0.468000													29	77					0	0	1	0	0
SH3RF3	344558	broad.mit.edu	37	2	110053528	110053528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:110053528C>T	ENST00000309415.6	+	7	1754	c.1754C>T	c.(1753-1755)tCg>tTg	p.S585L		NM_001099289.1	NP_001092759.1	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	585							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(5)|ovary(2)	18						CCCACAGCCTCGCCCCCAACA	0.682000													11	28					0	0	1	0	0
ANKRD13B	124930	broad.mit.edu	37	17	27935057	27935057	+	Missense_Mutation	SNP	C	C	T	rs148007819		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:27935057C>T	ENST00000394859.3	+	3	458	c.304C>T	c.(304-306)Cgg>Tgg	p.R102W	RP11-68I3.2_ENST00000581474.1_RNA	NM_152345.4	NP_689558.4	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	102										cervix(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	16						GCTGGTGCTTCGGTACCGGGA	0.682000													14	21					0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	354414	354414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:354414G>A	ENST00000262320.3	-	5	1515	c.1144C>T	c.(1144-1146)Cgc>Tgc	p.R382C	AXIN1_ENST00000481769.1_5'UTR|AXIN1_ENST00000354866.3_Missense_Mutation_p.R382C	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	382	Interaction with GSK3B (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.?(1)		biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GGCTCCACGCGGACCTCCTTC	0.632000													7	36					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46935494	46935494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46935494G>A	ENST00000313049.5	+	2	376	c.173G>A	c.(172-174)aGg>aAg	p.R58K	PTH1R_ENST00000490109.1_3'UTR|PTH1R_ENST00000418619.1_Missense_Mutation_p.R58K|PTH1R_ENST00000430002.2_Missense_Mutation_p.R58K|PTH1R_ENST00000449590.1_Missense_Mutation_p.R58K			Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	58						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						GTCCTGCAGAGGCCAGGTGGG	0.597000													5	31					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41465770	41465770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41465770G>A	ENST00000400454.1	-	21	4205	c.3728C>T	c.(3727-3729)tCg>tTg	p.S1243L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1243	Fibronectin type-III 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTAGGAAAACGAGTCGGGAGA	0.478000													19	49					0	0	1	0	0
FRRS1	391059	broad.mit.edu	37	1	100182983	100182983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100182983C>T	ENST00000414213.1	-	11	1820	c.1219G>A	c.(1219-1221)Gaa>Aaa	p.E407K	FRRS1_ENST00000287474.5_Missense_Mutation_p.E407K			Q6ZNA5	FRRS1_HUMAN	ferric-chelate reductase 1	407	Cytochrome b561.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	26		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		CAAGCTGCTTCACCAAGCAAG	0.403000													42	126					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103173923	103173923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103173923C>T	ENST00000375735.2	+	76	11341	c.11197C>T	c.(11197-11199)Cct>Tct	p.P3733S	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.P3740S	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3733	AAA 6 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GGGTGCTGATCCTTCTCAGGA	0.413000													14	46					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88853872	88853872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88853872G>A	ENST00000537554.1	-	2	4684	c.1122C>T	c.(1120-1122)ctC>ctT	p.L374L	CNR1_ENST00000549890.1_Silent_p.L374L|CNR1_ENST00000468898.1_Silent_p.L341L|CNR1_ENST00000535130.1_Silent_p.L374L|CNR1_ENST00000549716.1_Silent_p.L313L|CNR1_ENST00000369501.2_Silent_p.L374L|CNR1_ENST00000428600.2_Silent_p.L374L|CNR1_ENST00000369499.2_Silent_p.L374L|CNR1_ENST00000362094.5_3'UTR	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	374					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CCGTCTTAATGAGCTTGTTCA	0.512000													31	52					0	0	1	0	0
RP11-407N17.3	0	broad.mit.edu	37	14	39717177	39717177	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:39717177C>T	ENST00000553728.1	+	4	1612	c.1399C>T	c.(1399-1401)Cct>Tct	p.P467S	MIA2_ENST00000556784.1_Missense_Mutation_p.P466S|MIA2_ENST00000280082.3_Missense_Mutation_p.P467S																							TTTTGACAACCCTTGGAACTT	0.323000													40	83					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724463	138724463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:138724463G>A	ENST00000383163.2	-	1	647	c.648C>T	c.(646-648)ttC>ttT	p.F216F		NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	216	Pro-rich.									endometrium(3)|kidney(1)|lung(7)	11						ATTCCGGGTCGAAGAAGGGGC	0.662000													5	10					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42341730	42341730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42341730C>T	ENST00000217026.4	+	12	1935	c.1808C>T	c.(1807-1809)cCc>cTc	p.P603L	MYBL2_ENST00000396863.4_Missense_Mutation_p.P579L	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	603						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TCCACACTGCCCAAGTCTCTA	0.527000													11	16					0	0	1	0	0
OPRD1	4985	broad.mit.edu	37	1	29189342	29189342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:29189342C>T	ENST00000234961.2	+	3	908	c.666C>T	c.(664-666)ttC>ttT	p.F222F		NM_000911.3	NP_000902.3	P41143	OPRD_HUMAN	opioid receptor, delta 1	222					immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	TCTTCGCCTTCGTGGTGCCCA	0.647000													21	39					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135705	55135705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55135705G>A	ENST00000314706.3	+	1	346	c.346G>A	c.(346-348)Gag>Aag	p.E116K		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						CTTGCTCTCTGAGAAAAAGAC	0.403000													84	171					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400463	40400463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:40400463G>A	ENST00000338305.6	-	2	932	c.390C>T	c.(388-390)atC>atT	p.I130I		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	130						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGTTGTTCACGATAAGGTGCT	0.592000													12	44					0	0	1	0	0
PSMD9	5715	broad.mit.edu	37	12	122353804	122353804	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122353804C>T	ENST00000544724.1	+	3	2720	c.331C>T	c.(331-333)Cag>Tag	p.Q111*	PSMD9_ENST00000541212.1_Nonsense_Mutation_p.Q200*|RP11-87C12.2_ENST00000542602.1_Nonsense_Mutation_p.Q95*|RP11-87C12.2_ENST00000544911.1_3'UTR|PSMD9_ENST00000261817.2_Nonsense_Mutation_p.Q199*			O00233	PSMD9_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	200	PDZ.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of insulin secretion|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of insulin secretion|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	nucleus|proteasome regulatory particle	bHLH transcription factor binding|transcription coactivator activity			endometrium(1)|large_intestine(1)|lung(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000117)|Epithelial(86;0.000415)|BRCA - Breast invasive adenocarcinoma(302;0.231)		GGAAAAACACCAGCTTAGACT	0.468000													4	27					0	0	1	0	0
TM4SF20	79853	broad.mit.edu	37	2	228243815	228243815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228243815C>T	ENST00000304568.3	-	1	207	c.170G>A	c.(169-171)gGa>gAa	p.G57E		NM_024795.3	NP_079071.2	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	57						integral to membrane|plasma membrane		p.G57A(1)		breast(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(2)	10		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		CAGACCTGCTCCTATAATTCC	0.418000													26	82					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58118625	58118625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58118625C>T	ENST00000357272.4	+	26	4646	c.4481C>T	c.(4480-4482)tCa>tTa	p.S1494L	FLNB_ENST00000358537.3_Missense_Mutation_p.S1494L|FLNB_ENST00000295956.4_Missense_Mutation_p.S1494L|FLNB_ENST00000429972.2_Missense_Mutation_p.S1494L|FLNB_ENST00000490882.1_Missense_Mutation_p.S1525L|FLNB_ENST00000348383.5_Missense_Mutation_p.S1494L|FLNB_ENST00000419752.2_Missense_Mutation_p.S1325L|FLNB_ENST00000493452.1_Missense_Mutation_p.S1325L			O75369	FLNB_HUMAN	filamin B, beta	1494	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TACATGGTCTCAGTTAAATAT	0.512000													12	22					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868352	97868352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97868352G>A	ENST00000437310.1	+	1	183	c.123G>A	c.(121-123)ggG>ggA	p.G41G		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CCATCATGGGGAATCTTGGTC	0.403000													101	281					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783434	54783434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54783434G>A	ENST00000391748.1	-	5	551	c.424C>T	c.(424-426)Ctc>Ttc	p.L142F	LILRB2_ENST00000434421.1_Missense_Mutation_p.L26F|LILRB2_ENST00000391746.1_Missense_Mutation_p.L142F|LILRB2_ENST00000314446.5_Missense_Mutation_p.L142F|LILRB2_ENST00000391749.4_Missense_Mutation_p.L142F	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	142	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity	p.L142V(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACACTGGAGGGTCACCCTT	0.582000													39	107					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29587275	29587275	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:29587275A>T	ENST00000373779.3	+	7	1133	c.1004A>T	c.(1003-1005)cAc>cTc	p.H335L	PTPRU_ENST00000323874.8_Missense_Mutation_p.H335L|PTPRU_ENST00000356870.3_Missense_Mutation_p.H335L|PTPRU_ENST00000345512.3_Missense_Mutation_p.H335L|PTPRU_ENST00000428026.2_Missense_Mutation_p.H335L|PTPRU_ENST00000460170.2_Missense_Mutation_p.H335L	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	335	Fibronectin type-III 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GCTGAGGTGCACGCCGTCAGC	0.642000													24	44					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50235567	50235567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50235567C>T	ENST00000338821.5	-	20	2395	c.2131G>A	c.(2131-2133)Gag>Aag	p.E711K	ATP9A_ENST00000311637.5_Missense_Mutation_p.E575K|ATP9A_ENST00000402822.1_Missense_Mutation_p.E590K	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	711					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						AGGTGAGCCTCCCCGCGGTTG	0.592000													13	36					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74015056	74015056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74015056C>T	ENST00000301607.3	-	11	1476	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	EVPL_ENST00000586740.1_Missense_Mutation_p.R408Q	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	408	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GGGGTTTCTTCGCTGTGGCAG	0.682000													4	13					0	0	1	0	0
TRAV25	28658	broad.mit.edu	37	14	22580921	22580921	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22580921G>A	ENST00000390454.2	+	0	340																											AAGCAAAAAAGAACAGCTCCC	0.483000													12	20					0	0	1	0	0
CYP2S1	29785	broad.mit.edu	37	19	41704373	41704373	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41704373C>T	ENST00000310054.4	+	4	716	c.500C>T	c.(499-501)cCa>cTa	p.P167L	CYP2S1_ENST00000542619.1_Intron	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	167					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						CCAGGACGCCCATTCGATCCC	0.632000													59	135					0	0	1	0	0
SLC38A9	153129	broad.mit.edu	37	5	54929585	54929585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54929585G>A	ENST00000396865.2	-	14	2018	c.1427C>T	c.(1426-1428)cCt>cTt	p.P476L	SLC38A9_ENST00000416547.2_Missense_Mutation_p.P352L|SLC38A9_ENST00000318672.3_Missense_Mutation_p.P476L|SLC38A9_ENST00000512595.1_Missense_Mutation_p.P413L|SLC38A9_ENST00000539768.1_3'UTR|SLC38A9_ENST00000515629.1_Missense_Mutation_p.P413L	NM_173514.3	NP_775785.2	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	476					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				CCCTTACCTAGGATAAATGTC	0.458000													15	33					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50906815	50906815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50906815C>T	ENST00000440232.2	+	10	1256	c.1203C>T	c.(1201-1203)ttC>ttT	p.F401F	POLD1_ENST00000595904.1_Silent_p.F401F|POLD1_ENST00000599857.1_Silent_p.F401F	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	401					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding	p.F401F(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		TCCAGAACTTCGACCTTCCGT	0.627000								DNA polymerases (catalytic subunits)					61	135					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584900	1584900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1584900G>A	ENST00000381297.4	-	2	762	c.552C>T	c.(550-552)ctC>ctT	p.L184L		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	184						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCACGCTGGGGAGCATCGTCC	0.627000			T	CRLF2	"""B-ALL, Downs associated ALL"""								13	48					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674333	4674333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4674333G>A	ENST00000396952.5	+	2	1227	c.577G>A	c.(577-579)Gat>Aat	p.D193N	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D192Y(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTGGCCTGTGATGATATCCG	0.498000													73	125					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62288674	62288674	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62288674G>A	ENST00000378024.4	-	5	13489	c.13215C>T	c.(13213-13215)gtC>gtT	p.V4405V	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4405					nervous system development	nucleus	protein binding	p.V4405V(1)		NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGGGCAGAGAGACATCCACAT	0.468000													95	225					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24813411	24813411	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24813411G>A	ENST00000376451.2	+	8	1925	c.1665G>A	c.(1663-1665)gcG>gcA	p.A555A	KIAA1217_ENST00000307544.6_Silent_p.A555A|KIAA1217_ENST00000458595.1_Silent_p.A837A|KIAA1217_ENST00000396446.1_Silent_p.A555A|KIAA1217_ENST00000430453.2_Intron|KIAA1217_ENST00000376462.1_Silent_p.A792A|KIAA1217_ENST00000396445.1_Silent_p.A555A|KIAA1217_ENST00000376452.3_Silent_p.A837A|KIAA1217_ENST00000376454.3_Silent_p.A872A			Q5T5P2	SKT_HUMAN	KIAA1217	872					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTGGCGATGCGAAGTCGGAAG	0.642000													18	48					0	0	1	0	0
ZNF230	7773	broad.mit.edu	37	19	44514663	44514663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44514663C>T	ENST00000429154.2	+	5	700	c.472C>T	c.(472-474)Cct>Tct	p.P158S		NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	158	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				CTTTGATCCTCCTCAGCAGTT	0.438000													59	133					0	0	1	0	0
SH3GL1	6455	broad.mit.edu	37	19	4365544	4365544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4365544G>A	ENST00000269886.3	-	4	444	c.266C>T	c.(265-267)tCg>tTg	p.S89L	SH3GL1_ENST00000598564.1_Intron|SH3GL1_ENST00000417295.2_Intron	NM_003025.3	NP_003016.1	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	89	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			NS(1)|endometrium(2)|kidney(16)|large_intestine(3)|lung(2)|ovary(2)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		AAGCCCCTCCGACTGCGGGTA	0.652000			T	MLL	AL								37	99					0	0	1	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27788253	27788253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27788253C>T	ENST00000396319.2	+	2	198	c.110C>T	c.(109-111)aCc>aTc	p.T37I	TAX1BP1_ENST00000265393.6_Missense_Mutation_p.T37I|TAX1BP1_ENST00000433216.2_5'UTR|TAX1BP1_ENST00000409980.1_Missense_Mutation_p.T37I|TAX1BP1_ENST00000543117.1_Missense_Mutation_p.T37I	NM_006024.6	NP_006015.4	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I) binding protein 1	37					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(8)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31			GBM - Glioblastoma multiforme(3;0.0823)			TGTCATTACACCTTAACTCCA	0.368000													11	48					0	0	1	0	0
RAG2	5897	broad.mit.edu	37	11	36615272	36615272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:36615272C>T	ENST00000311485.3	-	2	608	c.447G>A	c.(445-447)ggG>ggA	p.G149G		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	149					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				CCATACTTTTCCCTCGGCTGT	0.453000									Familial Hemophagocytic Lymphohistiocytosis				45	79					0	0	1	0	0
IL13	3596	broad.mit.edu	37	5	131995954	131995954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131995954C>T	ENST00000304506.3	+	4	435	c.421C>T	c.(421-423)Cgc>Tgc	p.R141C	IL13_ENST00000468334.1_3'UTR|AC004041.2_ENST00000435042.1_RNA	NM_002188.2	NP_002179.2	P35225	IL13_HUMAN	interleukin 13	141					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			large_intestine(1)|lung(1)|ovary(1)|skin(3)	6		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAAACTTTTTCGCGAGGGACA	0.418000													18	60					0	0	1	0	0
LINC00639	283547	broad.mit.edu	37	14	39304962	39304962	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:39304962C>T	ENST00000553932.1	-	0	3600																											GAAGGCCTTTCGGCACAGCTT	0.552000													4	18					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117993048	117993048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117993048G>A	ENST00000425217.1	-	9	1411	c.1357C>T	c.(1357-1359)Cct>Tct	p.P453S	KSR2_ENST00000302438.5_Missense_Mutation_p.P179S|KSR2_ENST00000339824.5_Missense_Mutation_p.P482S|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	482					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCCGTAGAGGGTTGTTGATG	0.493000													11	21					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33549452	33549452	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33549452C>T	ENST00000504830.1	-	21	4497	c.4162G>A	c.(4162-4164)Gag>Aag	p.E1388K	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.E1303K	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1388	TSP type-1 6.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CACTGAATCTCGCGTATCTTG	0.562000										HNSCC(64;0.19)			19	119					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125875776	125875776	+	Missense_Mutation	SNP	G	G	A	rs145492265		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:125875776G>A	ENST00000392693.3	-	9	1856	c.1729C>T	c.(1729-1731)Cct>Tct	p.P577S	CDON_ENST00000263577.7_Missense_Mutation_p.P577S	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	577	Fibronectin type-III 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding	p.P577S(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		GGGGCATCAGGAACAGAGATG	0.562000													33	76					0	0	1	0	0
SLC24A4	123041	broad.mit.edu	37	14	92915537	92915537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92915537C>T	ENST00000532405.1	+	10	1083	c.857C>T	c.(856-858)cCt>cTt	p.P286L	SLC24A4_ENST00000393265.2_Missense_Mutation_p.P222L|SLC24A4_ENST00000298877.1_Missense_Mutation_p.P269L|SLC24A4_ENST00000531433.1_Intron|SLC24A4_ENST00000351924.5_Intron			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	286						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		TATGATGACCCTTCCGTGCCA	0.502000													16	40					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230877	39230877	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39230877C>T	ENST00000340369.3	-	2	288	c.60G>A	c.(58-60)gaG>gaA	p.E20E	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Silent_p.E20E	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	20	Interaction with VASP.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGGCAGGTCCTCTGCAGTTG	0.617000													20	35					0	0	1	0	0
SLC17A1	6568	broad.mit.edu	37	6	25811878	25811878	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25811878A>G	ENST00000244527.4	-	9	1133	c.1018T>C	c.(1018-1020)Ttc>Ctc	p.F340L	SLC17A1_ENST00000468082.1_Missense_Mutation_p.F286L|SLC17A1_ENST00000427328.1_Missense_Mutation_p.F286L|SLC17A1_ENST00000476801.1_Missense_Mutation_p.F340L	NM_005074.3	NP_005065.2	Q14916	NPT1_HUMAN	solute carrier family 17 (organic anion transporter), member 1	340					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	36						GCTGCTGTGAAGAGTTTCCGG	0.458000													14	90					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19337746	19337746	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19337746C>T	ENST00000252575.5	+	7	1567	c.1524C>T	c.(1522-1524)gcC>gcT	p.A508A		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	508					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			AGGCCAGCGCCCAGCCCCCCA	0.652000													17	28					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10223741	10223741	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10223741C>T	ENST00000418404.3	-	24	3347	c.3184G>A	c.(3184-3186)Gat>Aat	p.D1062N	MYH13_ENST00000570743.1_Missense_Mutation_p.D1062N|RP11-401O9.3_ENST00000577743.1_RNA|MYH13_ENST00000252172.4_Missense_Mutation_p.D1062N			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1062					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						ATTTTCAGATCTCCTTCCAGC	0.423000													7	7					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56276946	56276946	+	Missense_Mutation	SNP	G	G	A	rs149447728		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56276946G>A	ENST00000225371.5	+	9	1438	c.1328G>A	c.(1327-1329)cGg>cAg	p.R443Q		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	443					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						GGCAAGGCCCGGGCCAGGAGA	0.597000													37	48					0	0	1	0	0
DTX3	196403	broad.mit.edu	37	12	58000277	58000277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58000277C>T	ENST00000551632.1	+	3	140	c.5C>T	c.(4-6)cCa>cTa	p.P2L	DTX3_ENST00000337737.3_5'UTR|DTX3_ENST00000548804.1_5'UTR|DTX3_ENST00000548198.1_5'UTR			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	0					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					GCCTGCATGCCAATTCTAAGC	0.502000													9	21					0	0	1	0	0
CHST2	9435	broad.mit.edu	37	3	142840893	142840893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142840893C>T	ENST00000309575.3	+	2	2619	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	412					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						GCCCTGCAGCCCCCTGACTGG	0.617000													28	49					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20990797	20990797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20990797C>T	ENST00000261383.3	-	50	7930	c.7931G>A	c.(7930-7932)cGa>cAa	p.R2644Q	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2644	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GTTGTGTCTTCGAAGTTTGTT	0.478000													32	67					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884482	228884482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228884482C>T	ENST00000392056.3	-	7	1134	c.1088G>A	c.(1087-1089)aGa>aAa	p.R363K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.R363K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	363						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TAGGTTGCTTCTCTGCTCTGC	0.438000													34	101					0	0	1	0	0
ARG2	384	broad.mit.edu	37	14	68117433	68117433	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:68117433G>C	ENST00000261783.3	+	8	1041	c.859_splice	c.e8-1	p.G287_splice	VTI1B_ENST00000554659.1_3'UTR	NM_001172.3	NP_001163.1	P78540	ARGI2_HUMAN	arginase 2	287					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|ovary(1)|prostate(1)	11				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	TTCTTCCAGGGTTGCTATCAG	0.488000													7	64					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66859118	66859118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:66859118G>A	ENST00000359742.4	-	8	1049	c.809C>T	c.(808-810)tCg>tTg	p.S270L	GRIP1_ENST00000286445.7_Missense_Mutation_p.S270L|GRIP1_ENST00000398016.3_Missense_Mutation_p.S270L			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	270	PDZ 3.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		ACAGCACATCGAGGTAGTTAG	0.463000													35	76					0	0	1	0	0
KRTAP24-1	643803	broad.mit.edu	37	21	31654819	31654819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31654819G>A	ENST00000340345.4	-	1	457	c.432C>T	c.(430-432)acC>acT	p.T144T		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	144						keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						CGTTGCGGAGGGTTTGGCAGG	0.498000													36	122					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2718589	2718589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:2718589G>A	ENST00000382082.3	+	1	1088	c.850G>A	c.(850-852)Gag>Aag	p.E284K		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	284						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		CACCGTGGAGGAGATGCAGCA	0.672000													5	16					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95274346	95274346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95274346C>T	ENST00000344604.5	-	5	1266	c.1117G>A	c.(1117-1119)Gat>Aat	p.D373N	ECM2_ENST00000444490.2_Missense_Mutation_p.D351N|CENPP_ENST00000375587.3_Intron	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	373					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						TTACTCAGATCAAGCCTTTCC	0.393000													25	59					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40078519	40078519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40078519G>A	ENST00000336649.4	+	38	5701	c.5701G>A	c.(5701-5703)Gag>Aag	p.E1901K	CACNA1I_ENST00000404898.1_Missense_Mutation_p.E1860K|CACNA1I_ENST00000402142.3_Missense_Mutation_p.E1895K|CACNA1I_ENST00000401624.1_Missense_Mutation_p.E1895K|CACNA1I_ENST00000400164.3_Missense_Mutation_p.E1860K|CACNA1I_ENST00000407673.1_Missense_Mutation_p.E1860K			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1895					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGACCCACCTGAGCCCATGCG	0.607000													47	96					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87229949	87229949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87229949G>A	ENST00000297524.3	-	3	1032	c.929C>T	c.(928-930)tCa>tTa	p.S310L	SLC7A13_ENST00000419776.2_Missense_Mutation_p.S301L|SLC7A13_ENST00000520624.1_5'UTR	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	310						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						TGGTCTCGATGATTTAAATAT	0.383000													52	153					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24773215	24773215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24773215C>T	ENST00000221166.5	+	2	1960	c.1178C>T	c.(1177-1179)gCt>gTt	p.A393V	NEFM_ENST00000437366.2_Missense_Mutation_p.A393V|NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000433454.2_Missense_Mutation_p.A17V|NEFM_ENST00000518131.1_Missense_Mutation_p.A393V			P07197	NFM_HUMAN	neurofilament, medium polypeptide	393	Coil 2B.|Rod.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GTCAAGATGGCTCTGGATATA	0.547000													22	37					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222802183	222802183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:222802183C>T	ENST00000344922.5	+	4	1646	c.1621C>T	c.(1621-1623)Cac>Tac	p.H541Y	MIA3_ENST00000344507.1_Intron|MIA3_ENST00000344441.6_Missense_Mutation_p.H541Y|MIA3_ENST00000470521.1_3'UTR	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	541					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		AGGAATGCTCCACGAAGAAAA	0.413000													16	146					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15131471	15131471	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15131471G>A	ENST00000292574.3	+	3	956	c.874_splice	c.e3+1	p.A292_splice		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	292					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						CTATAACCCAGGTAGGAGTCC	0.602000													8	25					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373317	126373317	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126373317C>T	ENST00000394329.3	+	9	11159	c.11146C>T	c.(11146-11148)Cgt>Tgt	p.R3716C	FAT4_ENST00000335110.5_Missense_Mutation_p.R2014C	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3716					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R3716C(4)		NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CATCTTACTTCGTCTCGGCGT	0.468000													16	166					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7673916	7673916	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7673916C>T	ENST00000572933.1	+	26	5600	c.4140C>T	c.(4138-4140)ctC>ctT	p.L1380L	DNAH2_ENST00000389173.2_Silent_p.L1380L			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1380	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGACTCAGCTCGACATAGTAC	0.542000													29	47					0	0	1	0	0
SOHLH1	402381	broad.mit.edu	37	9	138586200	138586200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138586200G>A	ENST00000298466.5	-	7	1039	c.979C>T	c.(979-981)Ccc>Tcc	p.P327S	SOHLH1_ENST00000425225.1_Intron	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1	327					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		GCTTACGCGGGGGGACCAGCC	0.647000													12	34					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130897787	130897787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130897787C>T	ENST00000392984.3	-	4	1890	c.1147G>A	c.(1147-1149)Gag>Aag	p.E383K	CCDC74B_ENST00000409943.3_Missense_Mutation_p.E215K|CCDC74B_ENST00000310463.6_Missense_Mutation_p.E281K			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	281										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					TTCCACAGCTCGCGGATGAGC	0.682000													19	67					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68968189	68968189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68968189C>T	ENST00000288368.4	+	10	1495	c.1218C>T	c.(1216-1218)ttC>ttT	p.F406F	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	406	DEP 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TGACTACGTTCCCTAAATGCT	0.393000													29	86					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48699373	48699373	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:48699373G>A	ENST00000236495.5	+	10	1205	c.1155G>A	c.(1153-1155)ggG>ggA	p.G385G	SLC5A9_ENST00000533824.1_Silent_p.G381G|SLC5A9_ENST00000420136.2_3'UTR|SLC5A9_ENST00000438567.2_Silent_p.G360G	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	360						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						GAATCTGTGGGGCCCGAGTGG	0.562000													6	31					0	0	1	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435978	5435978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5435978G>A	ENST00000380419.3	-	4	880	c.843C>T	c.(841-843)ccC>ccT	p.P281P	TUBAL3_ENST00000479328.1_Silent_p.P241P	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	281					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						CAGAGACGATGGGGGCGAAGG	0.517000													39	107					0	0	1	0	0
FGL1	2267	broad.mit.edu	37	8	17726125	17726125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17726125C>T	ENST00000398056.2	-	9	1526	c.711G>A	c.(709-711)tgG>tgA	p.W237*	FGL1_ENST00000398054.1_Nonsense_Mutation_p.W237*|FGL1_ENST00000522444.1_Nonsense_Mutation_p.W237*|FGL1_ENST00000381840.2_Nonsense_Mutation_p.W237*|FGL1_ENST00000427924.1_Nonsense_Mutation_p.W237*|FGL1_ENST00000381841.2_Nonsense_Mutation_p.W237*|FGL1_ENST00000518650.1_Nonsense_Mutation_p.W237*			Q08830	FGL1_HUMAN	fibrinogen-like 1	237	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)	13				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		GATCTCTGTCCCACGTGCTGA	0.463000													58	131					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9489635	9489635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9489635C>T	ENST00000402466.1	+	16	2522	c.1754C>T	c.(1753-1755)tCa>tTa	p.S585L	SETD5_ENST00000402198.1_Missense_Mutation_p.S683L|SETD5_ENST00000407969.1_Missense_Mutation_p.S702L|SETD5_ENST00000488236.1_3'UTR|SETD5_ENST00000302463.6_Missense_Mutation_p.S585L|SETD5_ENST00000406341.1_Missense_Mutation_p.S683L			Q9C0A6	SETD5_HUMAN	SET domain containing 5	683										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		ACTGTGGTGTCAATTACTGGA	0.453000													10	20					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238726810	238726810	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238726810C>T	ENST00000316997.4	+	3	1383	c.1251C>T	c.(1249-1251)atC>atT	p.I417I	RBM44_ENST00000409864.1_Silent_p.I417I|RBM44_ENST00000444524.2_Intron	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	416							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		TACCAAAGATCGCAGTCAGAG	0.373000													17	38					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13183510	13183510	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:13183510G>A	ENST00000319217.7	-	19	2803	c.2556C>T	c.(2554-2556)atC>atT	p.I852I	MPDZ_ENST00000541718.1_Silent_p.I852I|MPDZ_ENST00000447879.1_Silent_p.I852I|MPDZ_ENST00000381015.4_Silent_p.I852I|MPDZ_ENST00000536827.1_Silent_p.I852I|MPDZ_ENST00000381022.2_Silent_p.I852I|MPDZ_ENST00000546205.1_Silent_p.I852I	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	852					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		GAGTAGAGTAGATGCTGTCAT	0.403000													5	27					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33590564	33590564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33590564G>A	ENST00000404816.2	+	31	5058	c.4705G>A	c.(4705-4707)Gat>Aat	p.D1569N	LTBP1_ENST00000402934.1_Missense_Mutation_p.D1188N|LTBP1_ENST00000354476.3_Missense_Mutation_p.D1570N|LTBP1_ENST00000404525.1_Missense_Mutation_p.D1190N|LTBP1_ENST00000407925.1_Missense_Mutation_p.D1243N|LTBP1_ENST00000272273.5_Missense_Mutation_p.D467N|LTBP1_ENST00000390003.4_Missense_Mutation_p.D1244N|LTBP1_ENST00000418533.2_Missense_Mutation_p.D1201N			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1569	TB 4.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCCCCTGAAGGATTCAGGTGA	0.542000													24	36					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128324336	128324336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128324336G>A	ENST00000262462.4	+	3	1739	c.729G>A	c.(727-729)agG>agA	p.R243R	SLC27A6_ENST00000395266.1_Silent_p.R243R|SLC27A6_ENST00000506176.1_Silent_p.R243R			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	243					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGGTTTTAAGGGGTTCTGCTG	0.393000													53	126					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177249597	177249597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177249597G>A	ENST00000361539.4	+	8	1597	c.1285G>A	c.(1285-1287)Gaa>Aaa	p.E429K	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		429						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CTACTGTGGGGAAAGCACCTT	0.542000													32	81					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177226448	177226448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177226448C>T	ENST00000361539.4	+	4	909	c.597C>T	c.(595-597)gcC>gcT	p.A199A	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		199						extracellular region		p.A199A(1)		breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AGCTGGCCGCCTCCTACTTCA	0.582000													12	38					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374046	27374046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27374046C>T	ENST00000395762.2	+	11	1632	c.1373C>T	c.(1372-1374)cCc>cTc	p.P458L	IL4R_ENST00000380922.3_Missense_Mutation_p.P443L|IL4R_ENST00000170630.2_Missense_Mutation_p.P458L|IL4R_ENST00000543915.2_Missense_Mutation_p.P458L	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	458	Required for IRS1 activation and IL4- induced cell growth.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GAGGCACCTCCCTGGGGCAAG	0.622000													17	69					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43214476	43214476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43214476C>T	ENST00000259750.4	+	2	161	c.78C>T	c.(76-78)gcC>gcT	p.A26A		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	26						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TCCTGCCGGCCAACTACGTGG	0.642000													13	34					0	0	1	0	0
TEKT1	83659	broad.mit.edu	37	17	6716194	6716194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6716194C>T	ENST00000338694.2	-	6	937	c.808G>A	c.(808-810)Gat>Aat	p.D270N	TEKT1_ENST00000535086.1_Missense_Mutation_p.D124N	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	270					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				TCCTTTGTATCCTTCAGCCCA	0.537000													49	75					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26165032	26165032	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26165032G>A	ENST00000335473.7	+	4	1399	c.1149G>A	c.(1147-1149)ggG>ggA	p.G383G	MYO18B_ENST00000536101.1_Silent_p.G383G|MYO18B_ENST00000407587.2_Silent_p.G383G	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	383						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCACGACTGGGAAGGCAGGTG	0.582000													11	20					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167863177	167863177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167863177G>A	ENST00000367848.1	-	8	963	c.466C>T	c.(466-468)Ctc>Ttc	p.L156F	ADCY10_ENST00000545172.1_Missense_Mutation_p.L95F|ADCY10_ENST00000367851.4_Missense_Mutation_p.L248F			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	248	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AGCCTCAGGAGGTCTAAGAAG	0.502000													9	28					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60635212	60635212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60635212C>T	ENST00000278853.5	+	1	178	c.178C>T	c.(178-180)Ctc>Ttc	p.L60F		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	60					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix		p.L60F(1)		breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						AGGCCAGACTCTCCGCTTCAA	0.677000													14	19					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8111504	8111504	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:8111504G>A	ENST00000379328.3	+	5	1561	c.993G>A	c.(991-993)agG>agA	p.R331R	GATA3_ENST00000461472.1_3'UTR|GATA3_ENST00000346208.3_Silent_p.R330R	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	330					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						TCTGGAGGAGGAATGCCAATG	0.557000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						41	80					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135384291	135384291	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:135384291C>T	ENST00000354042.4	-	8	1406	c.717G>A	c.(715-717)aaG>aaA	p.K239K		NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4	239						integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						GGACTTGTGGCTTTTCCTAAC	0.542000													17	47					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51839476	51839476	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51839476G>A	ENST00000251076.5	-	7	984	c.697C>T	c.(697-699)Cga>Tga	p.R233*	DMXL2_ENST00000543779.2_Nonsense_Mutation_p.R233*|DMXL2_ENST00000449909.3_Nonsense_Mutation_p.R233*	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	233						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		GTCACAGCTCGGGGATGTGCC	0.383000													28	82					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605356	140605356	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140605356G>A	ENST00000239449.4	+	1	2279	c.2279G>A	c.(2278-2280)gGg>gAg	p.G760E	PCDHB14_ENST00000515856.2_Missense_Mutation_p.G607E	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		760					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGTTCCGGGACAAATGAG	0.512000													43	122					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221230	161221230	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161221230G>A	ENST00000327928.4	+	4	934	c.934G>A	c.(934-936)Gac>Aac	p.D312N		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	312	Collagen-like 3.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						GCCGAAGGGTGACATTGGCAA	0.582000													8	23					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45821719	45821719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45821719C>T	ENST00000397928.1	+	16	2922	c.2477C>T	c.(2476-2478)tCc>tTc	p.S826F	TRPM2_ENST00000397932.2_Missense_Mutation_p.S826F|TRPM2_ENST00000300482.5_Missense_Mutation_p.S826F|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.S806F	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	826						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCTGTGCCCTCCTGGTGCGAG	0.632000													113	255					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166012313	166012313	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166012313G>A	ENST00000360093.3	-	10	1623	c.1132C>T	c.(1132-1134)Cga>Tga	p.R378*	SCN3A_ENST00000409101.3_Nonsense_Mutation_p.R378*|SCN3A_ENST00000283254.7_Nonsense_Mutation_p.R378*	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	378						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R378*(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GTCATGAGTCGAAATAGAGAC	0.413000													27	76					0	0	1	0	0
TLX1	3195	broad.mit.edu	37	10	102893963	102893963	+	Silent	SNP	G	G	A	rs7090185	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102893963G>A	ENST00000370196.6	+	2	2642	c.600G>A	c.(598-600)aaG>aaA	p.K200K	TLX1_ENST00000533319.1_3'UTR|TLX1_ENST00000467928.2_Silent_p.K200K			P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	200						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|upper_aerodigestive_tract(1)	2				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CGCCCCCCAAGAAGAAGAAGC	0.642000			T	"""TRB@, TRD@"""	T-ALL								3	10					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31736914	31736914	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31736914G>A	ENST00000375686.3	-	10	1621	c.1384C>T	c.(1384-1386)Cct>Tct	p.P462S	VWA7_ENST00000375688.4_Missense_Mutation_p.P462S|VWA7_ENST00000447450.1_Missense_Mutation_p.P462S|VWA7_ENST00000467576.1_5'UTR	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	462						extracellular region											AAACGCAGAGGGGACAAGATC	0.537000													16	67					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142723368	142723368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142723368G>A	ENST00000350513.2	-	1	914	c.852C>T	c.(850-852)ttC>ttT	p.F284F		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					GAGTAAAGATGAAAGGATTCA	0.438000													33	85					0	0	1	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37964343	37964343	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37964343C>T	ENST00000249014.4	+	3	1112	c.692C>T	c.(691-693)cCc>cTc	p.P231L		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	231	8 X 7 AA tandem repeats of [PT]-[AT]-A- [ENT]-[PT]-[PTS]-[AG].				positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					GCTGCAAACCCCCCAGCCCCT	0.667000													11	33					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99634720	99634720	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99634720G>A	ENST00000393483.3	-	20	2859	c.2015C>T	c.(2014-2016)tCa>tTa	p.S672L	TSGA10_ENST00000539964.1_Missense_Mutation_p.S672L|TSGA10_ENST00000410001.1_Missense_Mutation_p.S672L|TSGA10_ENST00000355053.4_Missense_Mutation_p.S672L	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	672	Interaction with HIF1A (By similarity).				spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						ACGTTCTGGTGAATGACATTT	0.418000													18	63					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13922279	13922279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13922279G>A	ENST00000265104.4	-	5	701	c.597C>T	c.(595-597)ttC>ttT	p.F199F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	199	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGGAGCTCAAGAACTCCTGGC	0.542000									Kartagener syndrome				17	34					0	0	1	0	0
HEPN1	641654	broad.mit.edu	37	11	124789726	124789726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124789726G>A	ENST00000408930.5	+	1	581	c.80G>A	c.(79-81)gGa>gAa	p.G27E	HEPACAM_ENST00000298251.4_3'UTR	NM_001037558.2	NP_001032647.2	Q6WQI6	HEPN1_HUMAN	hepatocellular carcinoma, down-regulated 1	27						cytoplasm				large_intestine(1)|lung(1)|stomach(1)	3	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		GGGATGCAAGGACCCTTGGAG	0.507000													5	68					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15826454	15826454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15826454C>T	ENST00000338282.6	-	27	3724	c.3618G>A	c.(3616-3618)gaG>gaA	p.E1206E	AF001548.5_ENST00000574212.1_RNA|MYH11_ENST00000300036.5_Silent_p.E1206E|MYH11_ENST00000452625.2_Silent_p.E1213E|MYH11_ENST00000396324.3_Silent_p.E1213E|MYH11_ENST00000576790.1_Silent_p.E1206E	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1206					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTGTGAGCTCCTCCACCGCCT	0.527000			T	CBFB	AML								39	151					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743056	26743056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26743056C>T	ENST00000396005.3	-	1	515	c.206G>A	c.(205-207)gGg>gAg	p.G69E	SLC5A12_ENST00000280467.6_Missense_Mutation_p.G69E	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	69					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						AGAAGGGGTCCCCAGGACCGT	0.527000													20	55					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24388527	24388527	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24388527C>T	ENST00000330966.7	-	33	4014	c.3852G>A	c.(3850-3852)ctG>ctA	p.L1284L	MYOM3_ENST00000338909.5_Silent_p.L174L|MYOM3_ENST00000374434.3_Silent_p.L1281L|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1281										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CTTTGGGGTCCAGGATGTGAA	0.522000													57	188					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41686444	41686444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41686444G>A	ENST00000313860.7	+	22	2778	c.2724G>A	c.(2722-2724)ggG>ggA	p.G908G	LIMCH1_ENST00000381753.4_Silent_p.G741G|LIMCH1_ENST00000513024.1_Silent_p.G761G|LIMCH1_ENST00000508501.1_Silent_p.G907G|LIMCH1_ENST00000512946.1_Silent_p.G908G|LIMCH1_ENST00000509277.1_Silent_p.G741G|LIMCH1_ENST00000511496.1_Silent_p.G748G|LIMCH1_ENST00000512820.1_Silent_p.G920G|LIMCH1_ENST00000503057.1_Silent_p.G1292G|LIMCH1_ENST00000512632.1_Silent_p.G831G|LIMCH1_ENST00000514096.1_Silent_p.G748G|LIMCH1_ENST00000396595.3_Silent_p.G753G	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	908					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						CTCATTCTGGGAACCCTGTAT	0.473000													20	75					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	91034604	91034604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91034604C>T	ENST00000268182.5	+	34	4412	c.4288C>T	c.(4288-4290)Cgt>Tgt	p.R1430C	IQGAP1_ENST00000560738.1_Missense_Mutation_p.R858C	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1430	C2.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			ACGTGCTATCCGTGATGCCAA	0.408000													13	83					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37262241	37262241	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37262241C>T	ENST00000310758.4	-	10	1406	c.759G>A	c.(757-759)aaG>aaA	p.K253K	ELMO1_ENST00000448602.1_Silent_p.K253K|ELMO1_ENST00000442504.1_Silent_p.K253K	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	253					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						CATCAGGAGCCTTCAGGAAAA	0.418000													30	82					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23927219	23927219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23927219G>A	ENST00000402377.3	-	4	1274	c.1133C>T	c.(1132-1134)tCc>tTc	p.S378F	ZNF681_ENST00000395385.3_Missense_Mutation_p.S309F	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AAGGTGTGAGGACTGCCTAAA	0.408000													35	92					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842311	5842311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5842311C>T	ENST00000317037.2	+	1	768	c.746C>T	c.(745-747)tCc>tTc	p.S249F	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	249			S -> A (in dbSNP:rs8181529).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACATGTGTTCCATTGTGATC	0.428000													11	117					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178565851	178565851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:178565851C>T	ENST00000286063.5	-	14	2559	c.2242G>A	c.(2242-2244)Gag>Aag	p.E748K	PDE11A_ENST00000358450.4_Missense_Mutation_p.E498K|PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000449286.2_Missense_Mutation_p.E390K|PDE11A_ENST00000409504.1_Missense_Mutation_p.E390K|AC012499.1_ENST00000412133.1_RNA|AC012499.1_ENST00000450227.1_RNA|PDE11A_ENST00000389683.3_Missense_Mutation_p.E304K	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	748	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GCCTGTACCTCACTTTGAAGG	0.502000									Primary Pigmented Nodular Adrenocortical Disease, Familial				7	27					0	0	1	0	0
KHSRP	8570	broad.mit.edu	37	19	6421694	6421694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6421694G>A	ENST00000398148.3	-	3	444	c.352C>T	c.(352-354)Ccg>Tcg	p.P118S		NM_003685.2	NP_003676.2	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	118	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|liver(1)|lung(6)|skin(1)|soft_tissue(1)	17						TTGCTCTCCGGTTGATCTGGG	0.582000													32	109					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	4107730	4107730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4107730C>T	ENST00000300737.4	+	11	2067	c.1498C>T	c.(1498-1500)Cgg>Tgg	p.R500W	STIM1_ENST00000527651.1_Missense_Mutation_p.R500W|STIM1_ENST00000533977.1_Missense_Mutation_p.R327W	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	500					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		GAGCAGTGTTCGGCAGCGCCT	0.592000													11	42					0	0	1	0	0
UPB1	51733	broad.mit.edu	37	22	24896103	24896103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24896103G>A	ENST00000326010.5	+	2	477	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	UPB1_ENST00000382760.2_Missense_Mutation_p.E45K|UPB1_ENST00000413389.2_Intron	NM_016327.2	NP_057411.1	Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	45					pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					GGAAGCTTTCGAAGCTGCCTC	0.522000													41	86					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57189311	57189311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57189311C>T	ENST00000343433.6	-	17	2004	c.1924G>A	c.(1924-1926)Gaa>Aaa	p.E642K		NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	642										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CTGTTCTTTTCTAAGTTTTGC	0.313000													14	38					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88761427	88761427	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88761427C>T	ENST00000444431.1	+	0	2557				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										CAATACAGCTCGTGTTCGACA	0.388000													68	133					0	0	1	0	0
ELOVL6	79071	broad.mit.edu	37	4	110972698	110972698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110972698G>A	ENST00000394607.3	-	5	757	c.594C>T	c.(592-594)atC>atT	p.I198I	ELOVL6_ENST00000302274.3_Silent_p.I198I			Q9H5J4	ELOV6_HUMAN	ELOVL fatty acid elongase 6	198					fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	8				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		GGGACAAGGTGATGAACATGG	0.517000													31	63					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46766894	46766894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46766894C>T	ENST00000230588.4	+	5	247	c.238C>T	c.(238-240)Cct>Tct	p.P80S		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	80	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			GTTCCCCATTCCTTACATCTT	0.438000													29	104					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27516588	27516588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27516588G>A	ENST00000301904.3	+	5	921	c.901G>A	c.(901-903)Gta>Ata	p.V301I	SCARA3_ENST00000337221.4_Missense_Mutation_p.V301I	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	301					response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		GCACGACCTGGTACTCCAGGT	0.562000													20	42					0	0	1	0	0
KLC2	64837	broad.mit.edu	37	11	66026257	66026257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66026257C>T	ENST00000417856.1	+	2	435	c.192C>T	c.(190-192)tcC>tcT	p.S64S	KLC2_ENST00000421552.1_Silent_p.S64S|KLC2_ENST00000316924.5_Silent_p.S64S|KLC2_ENST00000394066.2_Silent_p.S64S|KLC2_ENST00000394078.1_Silent_p.S64S|KLC2_ENST00000394067.2_Silent_p.S64S	NM_001134775.1	NP_001128247.1	Q9H0B6	KLC2_HUMAN	kinesin light chain 2	64					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						TGCGTCGCTCCCTGGAAGCCA	0.662000											OREG0021097	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	38					0	0	1	0	0
PMP2	5375	broad.mit.edu	37	8	82357107	82357107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:82357107G>A	ENST00000256103.2	-	2	327	c.191C>T	c.(190-192)tCc>tTc	p.S64F	PMP2_ENST00000519260.1_Intron|RP11-157I4.4_ENST00000524085.2_RNA	NM_002677.3	NP_002668.1	P02689	MYP2_HUMAN	peripheral myelin protein 2	64						cytoplasm	cholesterol binding|fatty acid binding|transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			Epithelial(68;0.186)			TAGCTTGAAGGAGATTTCTGT	0.388000													9	77					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41143071	41143071	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41143071C>T	ENST00000263413.3	-	18	2925	c.2661G>A	c.(2659-2661)caG>caA	p.Q887Q	C6_ENST00000337836.5_Silent_p.Q887Q	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	887	C5b-binding domain.|Complement control factor I module 2.|Kazal-like 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CCTTGAAGCACTGTGGGGGCA	0.433000													25	51					0	0	1	0	0
LRRC28	123355	broad.mit.edu	37	15	99828126	99828126	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:99828126G>A	ENST00000301981.3	+	5	595	c.355G>A	c.(355-357)Gct>Act	p.A119T	LRRC28_ENST00000442993.2_Missense_Mutation_p.A119T|LRRC28_ENST00000558879.1_Intron|LRRC28_ENST00000559399.1_3'UTR|LRRC28_ENST00000422500.2_Missense_Mutation_p.A119T|LRRC28_ENST00000331450.5_Intron|LRRC28_ENST00000447360.2_Missense_Mutation_p.A119T	NM_144598.2	NP_653199.2	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	119										endometrium(2)|large_intestine(3)|lung(6)|prostate(1)	12	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			TCTTCGATTAGCTAATAACCA	0.368000													26	160					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103324856	103324856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103324856G>A	ENST00000233969.2	+	12	2489	c.2347G>A	c.(2347-2349)Gaa>Aaa	p.E783K		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	783						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CAGTTTGACTGAAGGCATCCC	0.577000													36	119					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79428193	79428193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79428193C>T	ENST00000307745.7	+	30	6504	c.6504C>T	c.(6502-6504)ttC>ttT	p.F2168F	RP11-1055B8.8_ENST00000572590.1_RNA																							ACGCGCCCTTCGTCGGGGGGA	0.721000													4	12					0	0	1	0	0
APOL1	8542	broad.mit.edu	37	22	36661548	36661548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36661548G>A	ENST00000319136.4	+	7	981	c.714G>A	c.(712-714)ggG>ggA	p.G238G	APOL1_ENST00000347595.7_Silent_p.G101G|APOL1_ENST00000422706.1_Silent_p.G222G|APOL1_ENST00000426053.1_Silent_p.G204G|APOL1_ENST00000397279.4_Silent_p.G222G|APOL1_ENST00000397278.3_Silent_p.G222G|APOL1_ENST00000440669.2_3'UTR	NM_145343.2	NP_663318.1	O14791	APOL1_HUMAN	apolipoprotein L, 1	222					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	14						CTTTGACCGGGATTACCAGCA	0.557000													24	99					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70841800	70841800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70841800G>A	ENST00000393567.2	-	86	15199	c.15049C>T	c.(15049-15051)Ctc>Ttc	p.L5017F		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	5017										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ATTCCAAAGAGGGGGATGATA	0.537000													31	69					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872953	55872953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55872953C>T	ENST00000313503.1	+	1	435	c.435C>T	c.(433-435)atC>atT	p.I145I		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TCGCTCTCATCACTGGGCCTT	0.448000										HNSCC(53;0.14)			71	199					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62739693	62739693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62739693C>T	ENST00000371153.4	-	3	1461	c.1083G>A	c.(1081-1083)gaG>gaA	p.E361E	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	361										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GTGCCAGTTCCTCGGTTCTTC	0.567000													25	103					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90528592	90528592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90528592G>A	ENST00000282146.4	+	1	484	c.43G>A	c.(43-45)Gag>Aag	p.E15K		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	15						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CCACCTGAACGAGGACAACGC	0.756000													3	20					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169562877	169562877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169562877G>A	ENST00000263686.6	-	14	2410	c.2373C>T	c.(2371-2373)ctC>ctT	p.L791L	SELP_ENST00000367792.2_Silent_p.L607L|SELP_ENST00000458599.2_Silent_p.L607L|SELP_ENST00000367791.2_Silent_p.L605L|SELP_ENST00000367788.2_Silent_p.L729L|SELP_ENST00000367786.2_Silent_p.L729L|SELP_ENST00000367794.2_Silent_p.L729L|SELP_ENST00000367793.2_Silent_p.L729L	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	791					platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GCAAAGCCAGGAGCGTCCCAC	0.413000													9	58					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20651245	20651245	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20651245G>A	ENST00000428453.1	-	0	2392																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						AACTGTGGCAGAAGCACCTTG	0.502000													18	44					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92278668	92278668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92278668C>T	ENST00000435962.2	-	3	612	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K	TC2N_ENST00000340892.5_Missense_Mutation_p.E97K|TC2N_ENST00000360594.5_Missense_Mutation_p.E97K|TC2N_ENST00000556018.1_Missense_Mutation_p.E97K	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	97						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		TCAAGTTCTTCCAGATGTGAA	0.303000													13	36					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78853912	78853912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78853912G>A	ENST00000545128.1	+	23	3442	c.2904G>A	c.(2902-2904)gaG>gaA	p.E968E		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	664					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity	p.E968E(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						ACCAGGGAGAGTGTGGAGATA	0.527000													8	12					0	0	1	0	0
CUBNP3	100421634	broad.mit.edu	37	10	45644317	45644317	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45644317G>A	ENST00000427229.2	+	0	488																											TACCTAGAAAGTCACCAAGAC	0.338000													10	33					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82578909	82578909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82578909G>A	ENST00000423517.2	-	6	11332	c.10995C>T	c.(10993-10995)ccC>ccT	p.P3665P	PCLO_ENST00000333891.8_Silent_p.P3665P|PCLO_ENST00000437081.1_Silent_p.P385P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3596					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GACTTGCTGGGGGAACTTTAG	0.478000													27	284					0	0	1	0	0
PHYHD1	254295	broad.mit.edu	37	9	131702715	131702715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131702715C>T	ENST00000308941.5	+	9	923	c.503C>T	c.(502-504)tCg>tTg	p.S168L	PHYHD1_ENST00000487504.1_3'UTR|PHYHD1_ENST00000353176.5_Silent_p.I154I|PHYHD1_ENST00000421063.2_Silent_p.I154I|PHYHD1_ENST00000372592.3_Silent_p.I175I	NM_174933.3	NP_777593.2			phytanoyl-CoA dioxygenase domain containing 1											central_nervous_system(1)|endometrium(2)|large_intestine(3)|skin(1)|stomach(3)	10						GCGTGTGGATCGCAGTGGAGG	0.647000													23	77					0	0	1	0	0
IGHA1	3493	broad.mit.edu	37	14	106174793	106174793	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106174793C>T	ENST00000390547.2	-	0	209																											CCGGCAGGGTCAGCTGGCTGC	0.637000													13	54					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93629424	93629424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:93629424G>A	ENST00000375754.4	+	7	1006	c.858G>A	c.(856-858)gcG>gcA	p.A286A	SYK_ENST00000375751.4_Intron|SYK_ENST00000375747.1_Intron|SYK_ENST00000375746.1_Silent_p.A286A	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	286	Linker.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity	p.A286A(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						CTTGGTCAGCGGGTGGAATAA	0.443000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								25	76					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231264925	231264925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231264925G>A	ENST00000243810.6	+	15	1281	c.1281G>A	c.(1279-1281)gaG>gaA	p.E427E	SP140L_ENST00000444636.1_Silent_p.E427E|SP140L_ENST00000415673.2_Silent_p.E427E|SP140L_ENST00000396563.4_Silent_p.E392E			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	427						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						TCTTCCATGAGGACTGCCACA	0.512000													25	66					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50959019	50959019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50959019G>A	ENST00000374103.4	-	7	847	c.762C>T	c.(760-762)ttC>ttT	p.F254F	OGDHL_ENST00000419399.1_Silent_p.F197F|OGDHL_ENST00000432695.1_Silent_p.F45F	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	254					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TCCGGGCCAGGAAGTCTTCAA	0.567000													4	10					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57326923	57326923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57326923G>A	ENST00000326441.9	-	10	3250	c.2887C>T	c.(2887-2889)Cgc>Tgc	p.R963C	PEG3_ENST00000423103.2_Missense_Mutation_p.R963C|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.R837C|PEG3_ENST00000598410.1_Missense_Mutation_p.R839C|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	963					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R963C(2)		NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCTCGAGGGCGAAATGTTTGT	0.473000													60	163					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57395136	57395136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57395136G>A	ENST00000543257.1	-	13	2127	c.1561C>T	c.(1561-1563)Cct>Tct	p.P521S	C8B_ENST00000371237.4_Missense_Mutation_p.P573S|C8B_ENST00000535057.1_Missense_Mutation_p.P511S	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	573	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						CCATTTTGAGGAGGTGGATTG	0.483000													24	57					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110764073	110764073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:110764073G>A	ENST00000451085.1	+	4	2291	c.1245G>A	c.(1243-1245)atG>atA	p.M415I	IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000450877.1_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.M415I|LRRN3_ENST00000422987.3_Missense_Mutation_p.M415I	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	415	LRRCT.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TCAGGGACATGATGGAAATTT	0.443000													27	88					0	0	1	0	0
WFDC10B	280664	broad.mit.edu	37	20	44333618	44333618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44333618C>T	ENST00000335769.2	-	1	40	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	WFDC13_ENST00000305479.2_Intron|WFDC10B_ENST00000330523.5_5'UTR	NM_172131.2	NP_742143.1	Q8IUB3	WF10B_HUMAN	WAP four-disulfide core domain 10B	0						extracellular region	peptidase inhibitor activity			lung(2)|ovary(1)|stomach(1)	4		Myeloproliferative disorder(115;0.0122)				GCCCTCCTTTCACAAGACACC	0.488000													38	147					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337514	102337514	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:102337514G>A	ENST00000369138.1	+	11	2014		c.e11-1		GRIK2_ENST00000369137.3_Splice_Site|GRIK2_ENST00000413795.1_Splice_Site|GRIK2_ENST00000318991.6_Splice_Site|GRIK2_ENST00000369134.4_Splice_Site|GRIK2_ENST00000421544.1_Splice_Site	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2						glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TCTGTCTACAGAAAGCTGACC	0.318000													9	43					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73569208	73569208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73569208C>T	ENST00000392550.3	+	20	2691	c.2574C>T	c.(2572-2574)gaC>gaT	p.D858D	LLGL2_ENST00000577200.1_Silent_p.D858D|LLGL2_ENST00000167462.5_Silent_p.D858D	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	858					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			GAGCCGAGGACTACGGGGAGC	0.657000													17	42					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554157	140554157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140554157G>A	ENST00000231137.3	+	1	1915	c.1741G>A	c.(1741-1743)Gag>Aag	p.E581K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		581	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGCGGCCGAGCCGGGCTA	0.711000													37	119					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112172609	112172609	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112172609G>A	ENST00000412145.1	-	10	3560	c.1007C>T	c.(1006-1008)tCc>tTc	p.S336F	PTPN3_ENST00000374541.2_Missense_Mutation_p.S467F|PTPN3_ENST00000394827.3_5'UTR|PTPN3_ENST00000262539.3_Missense_Mutation_p.S313F|PTPN3_ENST00000446349.1_Missense_Mutation_p.S291F	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	467					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						AGGTGAGCAGGAGCCTGGAGC	0.537000													43	82					0	0	1	0	0
B3GALT1	8708	broad.mit.edu	37	2	168726366	168726366	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168726366C>T	ENST00000305861.1	+	2	1168	c.817C>T	c.(817-819)Cga>Tga	p.R273*	AC016723.4_ENST00000436982.2_RNA|B3GALT1_ENST00000392690.2_Nonsense_Mutation_p.R273*|AC016723.4_ENST00000430546.1_RNA	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	273					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						ACTGTGTCTTCGAAAGCTGGG	0.463000													26	64					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713060	46713060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46713060C>T	ENST00000318962.4	-	25	2782	c.2699G>A	c.(2698-2700)gGa>gAa	p.G900E	ALS2CL_ENST00000415953.1_Missense_Mutation_p.G900E|ALS2CL_ENST00000383742.3_Missense_Mutation_p.G247E	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	900	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GATCTCGGCTCCCAGGTGCTG	0.617000													14	65					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32065162	32065162	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32065162A>T	ENST00000375244.3	-	3	669	c.468T>A	c.(466-468)tgT>tgA	p.C156*	TNXB_ENST00000479795.1_Nonsense_Mutation_p.C156*|TNXB_ENST00000375247.2_Nonsense_Mutation_p.C156*			P22105	TENX_HUMAN	tenascin XB	156	EGF-like 1; incomplete.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCTCACAGGAACAGGTGCAGC	0.622000													12	39					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38855747	38855747	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38855747C>T	ENST00000409235.3	+	22	2718	c.2603C>T	c.(2602-2604)cCc>cTc	p.P868L	CATSPERG_ENST00000410018.1_Missense_Mutation_p.P828L|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	868					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						CACCTGGGGCCCCATATGCAA	0.602000													29	69					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986446	51986446	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51986446C>T	ENST00000396477.4	+	4	870	c.849C>T	c.(847-849)ctC>ctT	p.L283L	CEACAM18_ENST00000451626.1_Silent_p.L344L	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	344						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGATGAACCTCTCGAGTCTTG	0.532000													37	112					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6096664	6096664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6096664G>A	ENST00000217289.4	-	3	967	c.179C>T	c.(178-180)gCt>gTt	p.A60V	FERMT1_ENST00000536936.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	60					cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						CCACCAAAGAGCAAAGTCTGA	0.493000													15	37					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89971131	89971131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89971131C>T	ENST00000405460.2	+	24	5278	c.5182C>T	c.(5182-5184)Cca>Tca	p.P1728S	GPR98_ENST00000450321.2_3'UTR	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1728					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGCAGCGTTCCACATATCAC	0.547000													11	19					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151304071	151304071	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151304071G>A	ENST00000370323.4	-	4	338	c.22C>T	c.(22-24)Cag>Tag	p.Q8*	MAGEA10_ENST00000244096.3_Nonsense_Mutation_p.Q8*|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	8										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ATGCAGCGCTGACGCTTTGGA	0.602000													41	39					0	0	1	0	0
OASL	8638	broad.mit.edu	37	12	121469298	121469298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121469298G>A	ENST00000257570.5	-	3	874	c.604C>T	c.(604-606)Cgg>Tgg	p.R202W	OASL_ENST00000339275.5_Missense_Mutation_p.R202W	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	202					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTAGTTGGCCGATGTTTCACG	0.587000													30	76					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97851872	97851872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97851872G>A	ENST00000354565.2	+	1	331	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						TGTAACCACGGAATGTTTTCT	0.408000													94	220					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6832117	6832117	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6832117C>T	ENST00000304076.2	+	15	1508	c.1414C>T	c.(1414-1416)Ctc>Ttc	p.L472F	VAV1_ENST00000539284.1_Missense_Mutation_p.L375F|VAV1_ENST00000602142.1_Missense_Mutation_p.L472F|VAV1_ENST00000599806.1_Missense_Mutation_p.L417F|VAV1_ENST00000596764.1_Missense_Mutation_p.L440F	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	472	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CCACATGTTCCTCCTGATCGA	0.567000													16	36					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99153491	99153491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99153491G>A	ENST00000370992.4	-	4	591	c.480C>T	c.(478-480)tcC>tcT	p.S160S	RRP12_ENST00000414986.1_Intron|RRP12_ENST00000315563.6_Intron	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	160						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GGGACTCCGGGGACTCCACTG	0.527000													18	60					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32065163	32065163	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32065163C>T	ENST00000375244.3	-	3	668	c.467G>A	c.(466-468)tGt>tAt	p.C156Y	TNXB_ENST00000479795.1_Missense_Mutation_p.C156Y|TNXB_ENST00000375247.2_Missense_Mutation_p.C156Y			P22105	TENX_HUMAN	tenascin XB	156	EGF-like 1; incomplete.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CTCACAGGAACAGGTGCAGCG	0.617000													12	40					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61310809	61310809	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61310809C>T	ENST00000341074.5	-	2	118	c.3G>A	c.(1-3)atG>atA	p.M1I	SERPINB4_ENST00000356424.6_Start_Codon_SNP_p.M1I	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TGAGTGAATTCATGGTGAACT	0.373000													46	194					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100380631	100380631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100380631C>T	ENST00000262233.6	+	14	1749	c.1610C>T	c.(1609-1611)cCc>cTc	p.P537L	EML1_ENST00000334192.4_Missense_Mutation_p.P556L|EML1_ENST00000327921.9_Missense_Mutation_p.P525L	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	537						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GACTTCACACCCATTACTCAG	0.493000													27	72					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140746018	140746018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140746018C>T	ENST00000518069.1	+	1	2121	c.2121C>T	c.(2119-2121)ttC>ttT	p.F707F	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGGCCTTCGTCATCGTGC	0.602000													28	293					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6439002	6439002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6439002G>A	ENST00000162749.2	-	9	1298	c.999C>T	c.(997-999)ccC>ccT	p.P333P	TNFRSF1A_ENST00000540022.1_Silent_p.P290P	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	333					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						GGTTGGGGATGGGGTCGGAGG	0.667000													5	6					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55905119	55905119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55905119G>A	ENST00000301529.1	-	1	75	c.76C>T	c.(76-78)Ccc>Tcc	p.P26S		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AGGAAGAGGGGAATCTGGAGC	0.493000													41	132					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128661	126128661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:126128661G>A	ENST00000299308.3	+	6	1470	c.1462G>A	c.(1462-1464)Gaa>Aaa	p.E488K	TMEM132B_ENST00000535886.1_5'UTR	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	488						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAATGGGAAGGAAATGAAGAG	0.483000													22	62					0	0	1	0	0
C14orf105	55195	broad.mit.edu	37	14	57947410	57947410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:57947410C>T	ENST00000216445.3	-	5	694	c.558G>A	c.(556-558)agG>agA	p.R186R	C14orf105_ENST00000422976.2_Silent_p.R185R|C14orf105_ENST00000534126.1_Silent_p.R185R	NM_018168.2	NP_060638.2	Q9NVL8	CN105_HUMAN	chromosome 14 open reading frame 105	186										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)	11						CTTTATGGTCCCTTGGACTTT	0.418000													50	121					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25994397	25994397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:25994397G>A	ENST00000435504.4	-	6	709	c.416C>T	c.(415-417)tCc>tTc	p.S139F	ASXL2_ENST00000272341.4_5'UTR|ASXL2_ENST00000336112.4_Missense_Mutation_p.S111F|ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000404843.1_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	139	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGACTGCGGGGAGGACGACGA	0.463000													12	41					0	0	1	0	0
ZNF112	7665	broad.mit.edu	37	19	44833552	44833552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44833552G>A	ENST00000354340.4	-	4	809	c.758C>T	c.(757-759)cCa>cTa	p.P253L	ZNF112_ENST00000337401.4_Missense_Mutation_p.P259L|ZNF112_ENST00000536500.1_Missense_Mutation_p.P276L	NM_013380.3	NP_037512.3			zinc finger protein 112																		CCCAGTACATGGATAGGGCTT	0.428000													36	106					0	0	1	0	0
BOD1L2	284257	broad.mit.edu	37	18	54814709	54814709	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:54814709C>T	ENST00000585477.1	+	1	417	c.166C>T	c.(166-168)Cgc>Tgc	p.R56C		NM_001257964.1	NP_001244893.1			biorientation of chromosomes in cell division 1-like 2																		TGACAGCTTCCGCCGGGACTG	0.592000													4	9					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17721594	17721594	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17721594G>A	ENST00000434762.2	+	0	1536							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	ACAAGAATGAGGGCAAAAAGG	0.512000													34	90					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769799	140769799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140769799C>T	ENST00000519479.1	+	1	2348	c.2348C>T	c.(2347-2349)tCt>tTt	p.S783F	PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGATTCATCTGGGGCCTTA	0.388000													36	237					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520981	131520981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131520981G>A	ENST00000423981.1	+	2	1446	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	AMER3_ENST00000321420.4_Missense_Mutation_p.E446K	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GTGCGTGTCTGAGAGTCTGTC	0.662000													21	48					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1092112	1092112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1092112G>A	ENST00000441003.2	+	30	3958	c.3931G>A	c.(3931-3933)Gag>Aag	p.E1311K	MUC2_ENST00000359061.5_Missense_Mutation_p.E1312K	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1311						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CTGGATCAATGAGGACCACCC	0.592000													10	17					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20525739	20525739	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20525739C>T	ENST00000504154.1	+	14	1629	c.1377C>T	c.(1375-1377)agC>agT	p.S459S	SLIT2_ENST00000273739.5_Silent_p.S463S|SLIT2_ENST00000503823.1_Silent_p.S459S|SLIT2_ENST00000503837.1_Silent_p.S463S	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	459	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GTTGCACCAGCCCCCGCCGCC	0.488000													47	197					0	0	1	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176768298	176768298	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:176768298G>A	ENST00000430069.1	-	6	787	c.528C>T	c.(526-528)gcC>gcT	p.A176A	TBL1XR1_ENST00000457928.2_Silent_p.A176A			Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	176					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			CAGGGTTCCAGGCACAGATAA	0.363000													8	28					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33107014	33107014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33107014G>A	ENST00000307363.5	-	5	637	c.493C>T	c.(493-495)Ctt>Ttt	p.L165F	GLB1_ENST00000399402.3_Missense_Mutation_p.L135F|GLB1_ENST00000307377.8_Missense_Mutation_p.P94L|GLB1_ENST00000445488.2_Missense_Mutation_p.L213F	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	165					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				TTGGGCAGAAGGACTCCCAAC	0.512000													5	8					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179720208	179720208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179720208G>A	ENST00000420890.2	-	19	3043	c.2926C>T	c.(2926-2928)Cca>Tca	p.P976S	CCDC141_ENST00000295723.5_Missense_Mutation_p.P401S	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	401							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTATCACTTGGATAATTTAAG	0.294000													21	47					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46263977	46263977	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46263977C>T	ENST00000510861.1	-	9	1198	c.1025G>A	c.(1024-1026)tGg>tAg	p.W342*	GABRA2_ENST00000507069.1_Nonsense_Mutation_p.W342*|GABRA2_ENST00000356504.1_Nonsense_Mutation_p.W342*|GABRA2_ENST00000515082.1_Nonsense_Mutation_p.W342*|GABRA2_ENST00000381620.4_Nonsense_Mutation_p.W342*|GABRA2_ENST00000540012.1_Nonsense_Mutation_p.W287*|GABRA2_ENST00000514090.1_Nonsense_Mutation_p.W342*			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	342					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATCCCAAGCCCATCCTCTTTT	0.383000													33	111					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160141071	160141071	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160141071C>T	ENST00000368081.4	+	11	1993	c.1522C>T	c.(1522-1524)Cag>Tag	p.Q508*		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	508					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGACAGCTCCCAGACCCACGT	0.517000													42	117					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57732829	57732829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57732829G>A	ENST00000360716.3	+	4	492	c.271G>A	c.(271-273)Gag>Aag	p.E91K	CCDC135_ENST00000394337.4_Missense_Mutation_p.E91K|CCDC135_ENST00000336825.8_Missense_Mutation_p.E91K|RP11-405F3.4_ENST00000563062.1_RNA			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	91						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						CACACCCAAGGAGGAACACCT	0.572000													51	166					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141093193	141093193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141093193G>A	ENST00000389484.3	-	78	13078	c.12107C>T	c.(12106-12108)cCt>cTt	p.P4036L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4036					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCTCTTTTAGGATTTACTGC	0.378000										TSP Lung(27;0.18)			36	94					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190234049	190234049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190234049C>T	ENST00000367462.3	-	4	795	c.564G>A	c.(562-564)agG>agA	p.R188R	FAM5C_ENST00000484105.1_5'UTR|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000534846.1_Silent_p.R86R	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		188						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGGTGCTGTCCCTGTCAATGA	0.443000													43	99					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480105	73480105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73480105C>T	ENST00000523207.1	+	2	724	c.136C>T	c.(136-138)Cac>Tac	p.H46Y		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	46					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GGGCCTCAACCACGAAGTCCT	0.572000													42	79					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996466	140996466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140996466G>A	ENST00000285879.4	+	4	3562	c.3276G>A	c.(3274-3276)aaG>aaA	p.K1092K	MAGEC1_ENST00000406005.2_Silent_p.K159K	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1092	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCATGCTAAAGAATACCGTCC	0.453000										HNSCC(15;0.026)			85	61					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57340662	57340662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57340662G>A	ENST00000361249.3	+	3	308	c.212G>A	c.(211-213)gGa>gAa	p.G71E		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	71	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						AAGTTTGGGGGAACCATCTGC	0.473000													14	31					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713053	46713053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46713053C>T	ENST00000318962.4	-	25	2789	c.2706G>A	c.(2704-2706)gaG>gaA	p.E902E	ALS2CL_ENST00000415953.1_Silent_p.E902E|ALS2CL_ENST00000383742.3_Silent_p.E249E	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	902	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TCAGGTGGATCTCGGCTCCCA	0.612000													15	67					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66192132	66192132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66192132C>T	ENST00000311034.2	+	7	1947	c.1771C>T	c.(1771-1773)Cta>Tta	p.L591L		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	591					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GCTCTTGGCCCTAGCCCAGCT	0.587000													28	109					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41689912	41689912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41689912C>T	ENST00000313860.7	+	24	3046	c.2992C>T	c.(2992-2994)Cct>Tct	p.P998S	LIMCH1_ENST00000381753.4_Intron|LIMCH1_ENST00000513024.1_Intron|LIMCH1_ENST00000508501.1_Intron|LIMCH1_ENST00000512946.1_Intron|LIMCH1_ENST00000509277.1_Missense_Mutation_p.P831S|LIMCH1_ENST00000511496.1_Intron|LIMCH1_ENST00000512820.1_Intron|LIMCH1_ENST00000503057.1_Missense_Mutation_p.P1382S|LIMCH1_ENST00000512632.1_Intron|LIMCH1_ENST00000514096.1_Intron|LIMCH1_ENST00000396595.3_Intron	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	998					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TTCTCCCACCCCTCCCGGTCA	0.483000													24	82					0	0	1	0	0
MMP24	10893	broad.mit.edu	37	20	33851599	33851599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33851599G>A	ENST00000246186.6	+	5	908	c.823G>A	c.(823-825)Gac>Aac	p.D275N	MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000433764.1_RNA|MMP24-AS1_ENST00000566203.1_RNA|EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000438751.1_RNA|MMP24-AS1_ENST00000453892.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	275					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CACAGGGAACGACCTCTTCCT	0.627000													8	9					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	119986065	119986065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119986065G>A	ENST00000341846.5	-	8	2106	c.1685C>T	c.(1684-1686)tCt>tTt	p.S562F	TRIM29_ENST00000528870.1_Missense_Mutation_p.S95F|TRIM29_ENST00000529044.1_Missense_Mutation_p.S301F|TRIM29_ENST00000525887.1_5'UTR|TRIM29_ENST00000524816.3_Missense_Mutation_p.S128F|TRIM29_ENST00000541857.1_Missense_Mutation_p.S295F	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	562					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CTGCTTGCCAGATTTCCAAGT	0.612000													9	24					0	0	1	0	0
OR10H1	26539	broad.mit.edu	37	19	15918200	15918200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15918200G>A	ENST00000334920.2	-	1	736	c.648C>T	c.(646-648)ctC>ctT	p.L216L		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						CATAGGAGAGGAGGATGAGGA	0.577000													21	66					0	0	1	0	0
MECP2	4204	broad.mit.edu	37	X	153296314	153296314	+	Missense_Mutation	SNP	G	G	A	rs63749747		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153296314G>A	ENST00000303391.6	-	4	1214	c.965C>T	c.(964-966)cCc>cTc	p.P322L	MECP2_ENST00000453960.2_Missense_Mutation_p.P334L	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	322			P -> A (in RTT).|P -> L (in RTT).|P -> S (in MRXS13).		negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACCAGCAGGGGCTTCACCAC	0.597000													42	27					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159784074	159784074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159784074G>A	ENST00000321935.6	+	9	1246	c.1160G>A	c.(1159-1161)aGg>aAg	p.R387K	FCRL6_ENST00000392235.3_Missense_Mutation_p.R285K|FCRL6_ENST00000339348.5_Missense_Mutation_p.R380K|FCRL6_ENST00000368106.3_Missense_Mutation_p.R380K			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	380						integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					ACCTCAAAGAGGAGTGAAGGT	0.438000													23	45					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22157590	22157590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:22157590G>A	ENST00000389398.5	+	27	2860	c.2764G>A	c.(2764-2766)Gag>Aag	p.E922K	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	922						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		GACGCCCAGGGAGATGGAGGT	0.587000													3	24					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25296628	25296628	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25296628C>T	ENST00000549804.2	+	0	98				SNHG14_ENST00000552781.1_RNA|SNHG14_ENST00000547292.1_RNA|SNORD116-1_ENST00000384335.1_RNA																							GTGCTTGGATCGATGATGAGT	0.473000													53	126					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205306568	205306568	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205306568G>A	ENST00000367156.3	-	9	1828	c.1012C>T	c.(1012-1014)Ctg>Ttg	p.L338L	KLHDC8A_ENST00000539253.1_Silent_p.L338L|KLHDC8A_ENST00000537168.1_Silent_p.L225L|KLHDC8A_ENST00000460687.1_Silent_p.L204L|KLHDC8A_ENST00000367155.3_Silent_p.L338L	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	338										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCGTCACTCAGACCCTGGTTG	0.577000													32	112					0	0	1	0	0
TRGV3	6976	broad.mit.edu	37	7	38398396	38398396	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38398396C>T	ENST00000390346.2	-	0	253																											CTTCGTTCTCCCTTCCAAGTT	0.438000													19	105					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121577399	121577399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:121577399G>A	ENST00000275159.6	-	16	1765	c.1766C>T	c.(1765-1767)tCg>tTg	p.S589L	TBC1D32_ENST00000398212.2_Missense_Mutation_p.S589L					TBC1 domain family, member 32																		AAGTTTTTTCGAAAACTGGGC	0.338000													12	22					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	86068206	86068206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:86068206G>A	ENST00000373131.1	+	8	1587	c.1424G>A	c.(1423-1425)cGa>cAa	p.R475Q	DACH2_ENST00000477378.2_3'UTR|DACH2_ENST00000508860.1_Missense_Mutation_p.R321Q|DACH2_ENST00000510272.1_Missense_Mutation_p.R269Q|DACH2_ENST00000373125.4_Missense_Mutation_p.R488Q	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	488	DACHbox-C.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						AAGGAGCTGCGACTGGAGCTC	0.413000													15	7					0	0	1	0	0
RAB3IL1	5866	broad.mit.edu	37	11	61672252	61672252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61672252G>A	ENST00000394836.2	-	6	917	c.760C>T	c.(760-762)Ccc>Tcc	p.P254S	RAB3IL1_ENST00000301773.5_Missense_Mutation_p.P228S	NM_013401.2	NP_037533.2	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	254							protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(4)|skin(3)|urinary_tract(1)	14						TCCAGGCAGGGGCCCACGTCC	0.662000													12	7					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327538	57327538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57327538C>T	ENST00000326441.9	-	10	2635	c.2272G>A	c.(2272-2274)Gaa>Aaa	p.E758K	PEG3_ENST00000423103.2_Missense_Mutation_p.E758K|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.E632K|PEG3_ENST00000598410.1_Missense_Mutation_p.E634K|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	758					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCTGGTTTTCATAGGGGTTA	0.413000													75	194					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477162	128477162	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128477162G>A	ENST00000322313.4	-	16	2595	c.2437C>T	c.(2437-2439)Cct>Tct	p.P813S		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	813					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GGAGGGTGAGGTCCTCTCATC	0.617000													12	40					0	0	1	0	0
IKZF4	64375	broad.mit.edu	37	12	56417497	56417497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56417497C>T	ENST00000262032.5	+	6	497	c.130C>T	c.(130-132)Cct>Tct	p.P44S	IKZF4_ENST00000431367.2_Intron|IKZF4_ENST00000547167.1_Missense_Mutation_p.P44S|IKZF4_ENST00000547791.1_Intron|IKZF4_ENST00000548601.1_Intron			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	44					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGATTTCTTGCCTCAGGCCCA	0.448000													10	31					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50279643	50279643	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50279643C>T	ENST00000284509.6	-	10	834	c.693G>A	c.(691-693)ctG>ctA	p.L231L	ATP8B4_ENST00000558959.1_5'UTR|ATP8B4_ENST00000559829.1_Silent_p.L231L	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	231					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGCAGCCTCTCAGGATTATCT	0.448000													29	98					0	0	1	0	0
LHX5	64211	broad.mit.edu	37	12	113907014	113907014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113907014C>T	ENST00000261731.3	-	2	883	c.310G>A	c.(310-312)Gag>Aag	p.E104K		NM_022363.2	NP_071758.1	Q9H2C1	LHX5_HUMAN	LIM homeobox 5	104	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	10						ACGTAGAGCTCCTCGCCGGTG	0.572000													21	48					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76372279	76372279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76372279G>A	ENST00000407242.2	-	3	600	c.358C>T	c.(358-360)Ctg>Ttg	p.L120L	LRRC32_ENST00000260061.5_Silent_p.L120L|AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000404995.1_Silent_p.L120L|LRRC32_ENST00000464145.1_Intron	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	120						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						AGGGGGCCCAGGCCACCAGCA	0.692000													16	41					0	0	1	0	0
GALNT12	79695	broad.mit.edu	37	9	101608265	101608265	+	Missense_Mutation	SNP	G	G	A	rs137917376		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101608265G>A	ENST00000375011.3	+	9	1465	c.1465G>A	c.(1465-1467)Gag>Aag	p.E489K		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	489	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				TTAGTTTTTCGAGTACACGTC	0.478000													5	36					0	0	1	0	0
CD97	976	broad.mit.edu	37	19	14512561	14512561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14512561C>T	ENST00000242786.5	+	11	1252	c.1172C>T	c.(1171-1173)gCc>gTc	p.A391V	CD97_ENST00000357355.3_Missense_Mutation_p.A342V|CD97_ENST00000358600.3_Missense_Mutation_p.A298V	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	391					cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						GCAGCTGGAGCCGAGGATCCA	0.607000													4	26					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471756	47471756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:47471756G>A	ENST00000266581.4	-	2	1496	c.1030C>T	c.(1030-1032)Cac>Tac	p.H344Y	AMIGO2_ENST00000429635.1_Missense_Mutation_p.H344Y|AMIGO2_ENST00000321382.3_Missense_Mutation_p.H344Y|AMIGO2_ENST00000550413.1_Missense_Mutation_p.H344Y	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	344	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CTTCCATTGTGAAACACGTAA	0.423000													72	119					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038664	75038664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75038664G>A	ENST00000326665.5	-	14	2948	c.2730C>T	c.(2728-2730)gcC>gcT	p.A910A	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	910	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCAAGTTCAGGGCTGCTGCTT	0.542000													77	227					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20996624	20996624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20996624G>A	ENST00000261383.3	-	48	7439	c.7440C>T	c.(7438-7440)gtC>gtT	p.V2480V	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2480	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGGCCACACCGACCTGCAGTA	0.493000													28	20					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103068524	103068524	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103068524G>A	ENST00000264260.2	+	12	2272	c.1683G>A	c.(1681-1683)gtG>gtA	p.V561V	IL18RAP_ENST00000409369.1_Silent_p.V419V	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	561	TIR.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						ACATGCCTGTGAAAAACTCTC	0.473000													71	144					0	0	1	0	0
ZNF77	58492	broad.mit.edu	37	19	2936611	2936611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2936611G>A	ENST00000314531.4	-	3	314	c.222C>T	c.(220-222)ttC>ttT	p.F74F		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CACTTCCTGTGAACTTTACAA	0.413000													33	61					0	0	1	0	0
TNNT2	7139	broad.mit.edu	37	1	201332429	201332429	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201332429G>A	ENST00000509001.1	-	11	851	c.565C>T	c.(565-567)Cag>Tag	p.Q189*	TNNT2_ENST00000367315.2_Nonsense_Mutation_p.Q189*|TNNT2_ENST00000236918.7_Nonsense_Mutation_p.Q194*|TNNT2_ENST00000367318.5_Nonsense_Mutation_p.Q189*|TNNT2_ENST00000360372.4_Nonsense_Mutation_p.Q184*|TNNT2_ENST00000367317.4_Nonsense_Mutation_p.Q189*|TNNT2_ENST00000367320.2_Nonsense_Mutation_p.Q159*|TNNT2_ENST00000367322.1_Nonsense_Mutation_p.Q189*|TNNT2_ENST00000421663.2_Nonsense_Mutation_p.Q191*|TNNT2_ENST00000458432.2_Nonsense_Mutation_p.Q201*|TNNT2_ENST00000460780.1_5'UTR	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	199			S -> F (in CMH2).		ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						CCTACCTTCTGGATGTAACCC	0.552000													32	224					0	0	1	0	0
ANKRD7	56311	broad.mit.edu	37	7	117876926	117876926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117876926G>A	ENST00000357099.4	+	6	891	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K	ANKRD7_ENST00000417525.1_Missense_Mutation_p.E167K|ANKRD7_ENST00000477532.1_3'UTR|ANKRD7_ENST00000433239.1_Missense_Mutation_p.E167K|ANKRD7_ENST00000265224.4_Missense_Mutation_p.E220K			Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	220					male gonad development					breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)	29						ATTATGTTACGAAGGTATTGT	0.393000													73	210					0	0	1	0	0
CPSF6	11052	broad.mit.edu	37	12	69652691	69652691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:69652691C>T	ENST00000435070.2	+	6	1126	c.1016C>T	c.(1015-1017)cCt>cTt	p.P339L	CPSF6_ENST00000266679.8_Missense_Mutation_p.P376L|CPSF6_ENST00000551516.1_Intron|CPSF6_ENST00000456847.3_Missense_Mutation_p.P266L	NM_007007.2	NP_008938.2	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6, 68kDa	339	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(7)|lung(8)	16	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			ACACTAGCTCCTCCTCCGCAT	0.627000													41	172					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580008	140580008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580008C>T	ENST00000354757.3	+	1	661	c.661C>T	c.(661-663)Ccc>Tcc	p.P221S	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		221	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGGTCCCCTCCCAGGTCTGG	0.512000													37	100					0	0	1	0	0
ZNF136	7695	broad.mit.edu	37	19	12297482	12297482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12297482C>T	ENST00000343979.4	+	4	429	c.289C>T	c.(289-291)Cct>Tct	p.P97S	ZNF136_ENST00000398616.2_Missense_Mutation_p.P31S	NM_003437.3	NP_003428.1	P52737	ZN136_HUMAN	zinc finger protein 136	97					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			NS(1)|biliary_tract(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	18						CAAGAAAATCCCTGGAGTGAA	0.403000													23	73					0	0	1	0	0
CA3	761	broad.mit.edu	37	8	86358415	86358415	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:86358415C>T	ENST00000285381.2	+	6	635	c.552C>T	c.(550-552)ttC>ttT	p.F184F	RP11-317J10.2_ENST00000521761.1_RNA|RP11-317J10.2_ENST00000517697.1_RNA	NM_005181.3	NP_005172.1	P07451	CAH3_HUMAN	carbonic anhydrase III, muscle specific	184					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						CCTGCCTGTTCCCGGCATGCC	0.607000													8	20					0	0	1	0	0
BFSP2	8419	broad.mit.edu	37	3	133119161	133119161	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133119161C>T	ENST00000302334.2	+	1	323	c.234C>T	c.(232-234)ctC>ctT	p.L78L		NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	78	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						GCCGGGCCCTCGGCATCAGCA	0.647000													19	71					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120601056	120601056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120601056G>A	ENST00000300648.6	-	19	1868	c.1856C>T	c.(1855-1857)cCc>cTc	p.P619L		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	619					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGCCTCTAAGGGCAGCACCTG	0.572000													14	33					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327800	85327800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85327800C>T	ENST00000299927.3	+	1	1916	c.1894C>T	c.(1894-1896)Ctg>Ttg	p.L632L	ZNF592_ENST00000560079.2_Silent_p.L632L			Q92610	ZN592_HUMAN	zinc finger protein 592	632					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAAGTGCAGCCTGCTCCGGCA	0.592000													33	78					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179431928	179431928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179431928G>A	ENST00000589042.1	-	326	79155	c.78931C>T	c.(78931-78933)Cca>Tca	p.P26311S	TTN_ENST00000342992.6_Missense_Mutation_p.P23743S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P17246S|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P17438S|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P17371S|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P24670S|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24670	Fibronectin type-III 91.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTGAAGTGGTGGAGACCAT	0.448000													47	158					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189025997	189025997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189025997C>T	ENST00000512729.1	-	2	503	c.129G>A	c.(127-129)atG>atA	p.M43I	TRIML2_ENST00000536972.1_Missense_Mutation_p.M93I|TRIML2_ENST00000326754.3_Missense_Mutation_p.M43I	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	43							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TGACCTGAATCATCGCCATTC	0.358000													35	103					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165179969	165179969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165179969G>A	ENST00000342310.3	-	6	1096	c.714C>T	c.(712-714)gtC>gtT	p.V238V	RP11-38C18.2_ENST00000457106.1_RNA|LMX1A_ENST00000367893.4_Silent_p.V238V|LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Silent_p.V238V	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	238						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.V238V(1)		NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					ACACCTGGACGACACGGACAC	0.483000													18	35					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78943275	78943275	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:78943275C>T	ENST00000286627.5	-	5	1664	c.712G>A	c.(712-714)Gat>Aat	p.D238N	KCNMA1_ENST00000404857.1_Missense_Mutation_p.D238N|KCNMA1_ENST00000372443.1_Missense_Mutation_p.D238N|KCNMA1_ENST00000286628.8_Missense_Mutation_p.D238N|KCNMA1_ENST00000372440.1_Missense_Mutation_p.D238N|KCNMA1_ENST00000354353.5_Missense_Mutation_p.D238N|KCNMA1_ENST00000406533.3_Missense_Mutation_p.D238N|KCNMA1_ENST00000404771.3_Missense_Mutation_p.D238N	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	238					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CACAATTTATCGTTGGCTGCA	0.428000													7	24					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170235640	170235640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:170235640G>A	ENST00000518525.1	+	9	1180	c.716G>A	c.(715-717)cGg>cAg	p.R239Q	GABRP_ENST00000519385.1_Missense_Mutation_p.R239Q|GABRP_ENST00000519598.1_Missense_Mutation_p.R239Q|GABRP_ENST00000265294.4_Missense_Mutation_p.R239Q			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	239						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTTGAGCTTCGGAGGAATGTT	0.423000													21	59					0	0	1	0	0
NR5A1	2516	broad.mit.edu	37	9	127262850	127262850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127262850G>A	ENST00000373588.4	-	4	585	c.389C>T	c.(388-390)cCg>cTg	p.P130L		NM_004959.4	NP_004950.2	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	130					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			lung(1)|upper_aerodigestive_tract(1)	2						AGGGGGCGGCGGGGGCACCCC	0.701000													5	25					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104948865	104948865	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:104948865G>A	ENST00000507740.1	+	10	2074	c.1838G>A	c.(1837-1839)cGa>cAa	p.R613Q	RIMS2_ENST00000406091.3_Missense_Mutation_p.R821Q|RIMS2_ENST00000262231.10_Missense_Mutation_p.R660Q|RIMS2_ENST00000436393.2_Missense_Mutation_p.R599Q	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	883					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.R613Q(3)|p.R888Q(3)|p.R599Q(3)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCAGTCCACCGAAGAGAATTT	0.388000										HNSCC(12;0.0054)			36	123					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242757862	242757862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242757862G>A	ENST00000391969.2	+	5	1654	c.943G>A	c.(943-945)Gaa>Aaa	p.E315K	NEU4_ENST00000405370.1_Missense_Mutation_p.E315K|NEU4_ENST00000404257.1_Missense_Mutation_p.E327K|NEU4_ENST00000325935.6_Missense_Mutation_p.E328K|NEU4_ENST00000407683.1_Missense_Mutation_p.E315K	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	315	Pro-rich.					lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		TGGAGTCCACGAACCCCCAGA	0.716000													3	21					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70229978	70229978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:70229978G>A	ENST00000342771.4	+	8	1776	c.1455G>A	c.(1453-1455)ggG>ggA	p.G485G	AUTS2_ENST00000406775.2_Silent_p.G485G	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	485										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		ACCCGGCCGGGAGCACTTACT	0.627000													10	45					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153749612	153749612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153749612C>T	ENST00000271857.2	+	3	2096	c.1336C>T	c.(1336-1338)Cac>Tac	p.H446Y	SLC27A3_ENST00000368661.3_Missense_Mutation_p.H365Y|SLC27A3_ENST00000484014.1_3'UTR			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	365					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTGTGGTGTCCACCAGGAAGA	0.587000													36	105					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126531810	126531810	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126531810G>A	ENST00000373624.2	-	4	366	c.165C>T	c.(163-165)ttC>ttT	p.F55F	DENND1A_ENST00000373620.3_Silent_p.F55F|DENND1A_ENST00000394219.3_Silent_p.F23F|DENND1A_ENST00000394215.2_Silent_p.F25F|DENND1A_ENST00000373618.1_Intron|DENND1A_ENST00000473039.1_5'UTR	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	55	UDENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CATAGAAGGGGAAACAAAACT	0.338000													35	90					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9100069	9100069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9100069C>T	ENST00000383836.3	-	7	1316	c.889G>A	c.(889-891)Gaa>Aaa	p.E297K	SRGAP3_ENST00000433332.3_5'UTR|SRGAP3_ENST00000360413.3_Missense_Mutation_p.E297K	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	297					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCCAGCCCTTCGTGGCGAGAG	0.552000			T	RAF1	pilocytic astrocytoma								54	116					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202704705	202704705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202704705G>A	ENST00000367265.3	-	22	4439	c.3275C>T	c.(3274-3276)cCt>cTt	p.P1092L	KDM5B_ENST00000367264.2_Missense_Mutation_p.P1128L	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1092					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						ATCACATCGAGGACACAGCAC	0.388000													29	49					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18258340	18258340	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18258340G>A	ENST00000286479.3	+	2	934	c.827G>A	c.(826-828)gGg>gAg	p.G276E	NAT2_ENST00000520116.1_Missense_Mutation_p.G146E	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	276					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		ATTTCCTTGGGGAGAAATCTC	0.358000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				21	56					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94032059	94032059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94032059G>A	ENST00000282020.4	+	4	948	c.690G>A	c.(688-690)gcG>gcA	p.A230A	GRID2_ENST00000510992.1_Silent_p.A135A|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	230					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TTAGGCGAGCGATCCTTGTTA	0.383000													24	100					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19571806	19571806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:19571806C>T	ENST00000507958.1	-	10	2125	c.1135G>A	c.(1135-1137)Gaa>Aaa	p.E379K	CDH18_ENST00000382275.1_Missense_Mutation_p.E379K|CDH18_ENST00000274170.4_Missense_Mutation_p.E379K|CDH18_ENST00000502796.1_Missense_Mutation_p.E379K|CDH18_ENST00000511273.1_Missense_Mutation_p.E379K|CDH18_ENST00000506372.1_Missense_Mutation_p.E379K			Q13634	CAD18_HUMAN	cadherin 18, type 2	379	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGTGGTGGTTCATCTACATCC	0.428000													19	69					0	0	1	0	0
DLL3	10683	broad.mit.edu	37	19	39994874	39994874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39994874C>T	ENST00000205143.4	+	5	823	c.816C>T	c.(814-816)gtC>gtT	p.V272V	DLL3_ENST00000356433.5_Silent_p.V272V	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	272					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GATGCCTTGTCCCTGGGCCTG	0.642000													22	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179629027	179629027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179629027G>A	ENST00000589042.1	-	43	10215	c.9991C>T	c.(9991-9993)Cca>Tca	p.P3331S	TTN_ENST00000342992.6_Missense_Mutation_p.P3331S|TTN_ENST00000360870.5_Missense_Mutation_p.P3331S|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P3285S|TTN_ENST00000342175.6_Missense_Mutation_p.P3285S|TTN_ENST00000359218.5_Missense_Mutation_p.P3285S|TTN_ENST00000591111.1_Missense_Mutation_p.P3331S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3056							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAACTTCTGGAACTAAAGAA	0.448000													14	31					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66811188	66811188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66811188G>A	ENST00000393946.2	+	8	1863	c.701G>A	c.(700-702)aGc>aAc	p.S234N	SYT12_ENST00000527043.1_Missense_Mutation_p.S234N|SYT12_ENST00000525457.1_Missense_Mutation_p.S234N			Q8IV01	SYT12_HUMAN	synaptotagmin XII	234	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						GAGGAGAAGAGCCTGCGGTTT	0.557000													36	70					0	0	1	0	0
DMRT1	1761	broad.mit.edu	37	9	916880	916880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:916880C>T	ENST00000382276.3	+	4	1089	c.940C>T	c.(940-942)Ccc>Tcc	p.P314S	DMRT1_ENST00000569227.1_Missense_Mutation_p.P156S	NM_021951.2	NP_068770.2	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor 1	314					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(10)|ovary(1)	13		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		TGAGGATGCTCCCTCTTACCC	0.557000													8	79					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13323499	13323499	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13323499C>T	ENST00000360228.5	-	41	5995	c.5996G>A	c.(5995-5997)gGg>gAg	p.G1999E	CACNA1A_ENST00000573710.2_Missense_Mutation_p.G2000E	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	2000					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCCAGGTCCCCCTTCCTGCGT	0.687000													6	8					0	0	1	0	0
KHDC1L	100129128	broad.mit.edu	37	6	73935101	73935101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73935101C>T	ENST00000370388.3	-	1	74	c.31G>A	c.(31-33)Gag>Aag	p.E11K	KHDC1L_ENST00000471312.1_5'UTR|RP11-257K9.8_ENST00000423730.3_Silent_p.R113R	NM_001126063.2	NP_001119535.1	Q5JSQ8	KHDCL_HUMAN	KH homology domain containing 1-like	11										breast(1)|endometrium(1)|kidney(1)|lung(3)|skin(1)	7						CACCACGGCTCCTTGCTGAGA	0.537000													8	48					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130911970	130911970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130911970G>A	ENST00000409031.1	-	16	2804	c.1656C>T	c.(1654-1656)ttC>ttT	p.F552F	SMPD4_ENST00000453750.1_Silent_p.F301F|SMPD4_ENST00000431183.2_Silent_p.F450F|SMPD4_ENST00000452225.2_Silent_p.F293F|SMPD4_ENST00000339679.7_Silent_p.F410F|SMPD4_ENST00000351288.6_Silent_p.F523F|SMPD4_ENST00000426662.2_Silent_p.F188F|SMPD4_ENST00000443958.2_Silent_p.F216F	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	513					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	AGGGTGACAGGAAGCTCCCAG	0.607000													6	11					0	0	1	0	0
OR5V1	81696	broad.mit.edu	37	6	29323644	29323644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29323644G>A	ENST00000377154.1	-	4	628	c.329C>T	c.(328-330)tCa>tTa	p.S110L	OR5V1_ENST00000543825.1_Missense_Mutation_p.S110L			Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V, member 1	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(3)|large_intestine(3)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GAGACACTCTGATCCTACAAA	0.403000													28	68					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99564686	99564686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99564686G>A	ENST00000292401.4	-	4	973	c.837C>T	c.(835-837)tcC>tcT	p.S279S	AZGP1_ENST00000483612.1_5'UTR|AZGP1_ENST00000411734.1_3'UTR	NM_001185.3	NP_001176.1	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	279	Ig-like C1-type.				antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					GCACGTGGCAGGAGTAGGGGG	0.622000													35	106					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89251666	89251666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89251666G>A	ENST00000289746.2	+	5	653	c.588G>A	c.(586-588)caG>caA	p.Q196Q		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	196	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		TCCTGCAGCAGGGCAGCCCCG	0.667000													3	7					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74863238	74863238	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:74863238C>T	ENST00000358399.3	+	14	1438	c.1345C>T	c.(1345-1347)Ccg>Tcg	p.P449S	GDA_ENST00000376989.3_Missense_Mutation_p.P388S|GDA_ENST00000238018.4_Missense_Mutation_p.P449S|GDA_ENST00000545168.1_Missense_Mutation_p.P375S|GDA_ENST00000376986.1_Missense_Mutation_p.P371S	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	449					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GCAGGTGGTTCCGTTTTCCAG	0.448000													24	97					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34102044	34102044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34102044C>T	ENST00000373381.4	-	30	5061	c.4885G>A	c.(4885-4887)Gaa>Aaa	p.E1629K	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.E502K	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1589	CUB 10.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCTCAACTTCGTAGCCCCCG	0.622000													12	29					0	0	1	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474889	20474889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20474889C>T	ENST00000375102.3	+	5	733	c.631C>T	c.(631-633)Ccc>Tcc	p.P211S		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	168					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CCCCGCCCCTCCCTAGAGCCT	0.657000													9	48					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233273254	233273254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233273254C>T	ENST00000295453.3	+	7	879	c.827C>T	c.(826-828)tCc>tTc	p.S276F		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	276					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CTGCAGGCTTCCCTGGACCCG	0.652000													35	98					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599756	29599756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29599756G>A	ENST00000431530.3	+	1	1009	c.951G>A	c.(949-951)gaG>gaA	p.E317E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	307						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GAAAGGGAGAGGCCAAGCTGG	0.502000													17	28					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46243823	46243823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:46243823C>T	ENST00000334344.6	+	15	2089	c.1917C>T	c.(1915-1917)atC>atT	p.I639I	ARID2_ENST00000444670.1_Silent_p.I249I|ARID2_ENST00000422737.1_Silent_p.I490I|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	639					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTTCAGGAATCCCTCATGGAT	0.338000			"""N, S, F"""		hepatocellular carcinoma								36	54					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27963289	27963289	+	Silent	SNP	G	G	A	rs150233755	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:27963289G>A	ENST00000269033.3	-	14	2029	c.1878C>T	c.(1876-1878)tcC>tcT	p.S626S	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Silent_p.S653S	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	626					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CAGGATCAGGGGACATGGGGG	0.478000													8	72					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123267179	123267179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123267179C>T	ENST00000451558.1	+	11	1234	c.713C>T	c.(712-714)gCt>gTt	p.A238V	ASB15_ENST00000540573.1_Missense_Mutation_p.A238V|ASB15_ENST00000451215.1_Missense_Mutation_p.A238V|ASB15_ENST00000275699.3_Missense_Mutation_p.A238V|ASB15_ENST00000434204.1_Missense_Mutation_p.A238V			Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box containing 15	238					intracellular signal transduction					breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(3)	12						GATGTGCTTGCTTTGGCGGAT	0.507000													20	107					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94993239	94993239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94993239C>T	ENST00000265627.5	-	6	641	c.631G>A	c.(631-633)Gag>Aag	p.E211K	PON3_ENST00000427422.1_Missense_Mutation_p.E211K|PON1_ENST00000542556.1_Intron	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			ACTTTAACCTCCCTTGGGCTG	0.438000													79	196					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48713025	48713025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:48713025G>A	ENST00000236495.5	+	15	1981	c.1931G>A	c.(1930-1932)gGa>gAa	p.G644E	SLC5A9_ENST00000533824.1_Missense_Mutation_p.G640E|SLC5A9_ENST00000438567.2_Missense_Mutation_p.G619E|SLC5A9_ENST00000471020.1_3'UTR	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	619						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						AGGTCCTGGGGAAAGTTGCTC	0.557000													9	26					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657106	143657106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143657106C>T	ENST00000392899.1	+	1	80	c.43C>T	c.(43-45)Ctc>Ttc	p.L15F		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					ATTTATTCTCCTCGGCCTGTC	0.453000													59	136					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	8009922	8009922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8009922C>T	ENST00000318888.4	-	15	1456	c.585G>A	c.(583-585)aaG>aaA	p.K195K	ABLIM2_ENST00000296372.8_Silent_p.K461K|ABLIM2_ENST00000545242.1_Silent_p.K460K|ABLIM2_ENST00000505872.1_Silent_p.K408K|ABLIM2_ENST00000514025.1_Silent_p.K195K|ABLIM2_ENST00000546334.1_Silent_p.K419K|ABLIM2_ENST00000447017.2_Silent_p.K494K|ABLIM2_ENST00000341937.5_Silent_p.K460K|ABLIM2_ENST00000361581.5_Silent_p.K460K|ABLIM2_ENST00000361737.5_Silent_p.K419K|ABLIM2_ENST00000407564.3_Silent_p.K409K|ABLIM2_ENST00000428004.2_Silent_p.K420K			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	460	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						GCCAGCTGCTCTTCTGCTGAA	0.512000													13	68					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51258589	51258589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:51258589C>T	ENST00000395542.2	-	4	827	c.643G>A	c.(643-645)Gag>Aag	p.E215K	COBL_ENST00000395540.2_Missense_Mutation_p.E215K|COBL_ENST00000441453.1_Missense_Mutation_p.E215K|COBL_ENST00000265136.7_Missense_Mutation_p.E215K			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	215										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					ATCCCGAGCTCGTTCAGGGAC	0.592000													8	35					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148406911	148406911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148406911G>A	ENST00000538184.1	-	7	1913	c.1025C>T	c.(1024-1026)tCc>tTc	p.S342F	SH3TC2_ENST00000512049.1_Missense_Mutation_p.S788F|SH3TC2_ENST00000394358.2_Missense_Mutation_p.S680F|SH3TC2_ENST00000515425.1_Missense_Mutation_p.S795F			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	795							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACTCAAAGGATTCCTGCTC	0.567000													11	89					0	0	1	0	0
ITPRIPL1	150771	broad.mit.edu	37	2	96992898	96992898	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96992898C>T	ENST00000361124.4	+	1	964	c.553C>T	c.(553-555)Caa>Taa	p.Q185*	ITPRIPL1_ENST00000536814.1_Nonsense_Mutation_p.Q169*|ITPRIPL1_ENST00000439118.2_Nonsense_Mutation_p.Q177*|ITPRIPL1_ENST00000542887.1_Nonsense_Mutation_p.Q169*	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	177						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ACACTATGTCCAAAATGCCAT	0.547000													49	129					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198126	20198126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20198126C>T	ENST00000400331.5	-	5	2166	c.1858G>A	c.(1858-1860)Gag>Aag	p.E620K	MACC1_ENST00000589011.1_Missense_Mutation_p.E620K|MACC1_ENST00000332878.4_Missense_Mutation_p.E620K	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	620					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						ATTACTTGCTCCTTTGAAATC	0.358000													54	163					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79750470	79750470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79750470C>T	ENST00000305428.3	+	2	2056	c.1981C>T	c.(1981-1983)Ccc>Tcc	p.P661S		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	661						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CAGTGCCTCTCCCCGGATGTT	0.527000													108	132					0	0	1	0	0
UBN2	254048	broad.mit.edu	37	7	138978066	138978066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138978066C>T	ENST00000288561.8	+	16	3758	c.3509C>T	c.(3508-3510)cCt>cTt	p.P1170L	UBN2_ENST00000473989.2_Missense_Mutation_p.P1253L	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1253	Ser-rich.									NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						AATGTGACTCCTTTTGGGATG	0.488000													46	89					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987862	50987862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50987862C>T	ENST00000395676.2	+	1	1401	c.1267C>T	c.(1267-1269)Ccg>Tcg	p.P423S		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	423										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTGCTACGACCCGCGAACAGA	0.687000													24	109					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49386169	49386169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49386169G>A	ENST00000374201.3	-	22	3118	c.2816C>T	c.(2815-2817)tCa>tTa	p.S939L	FRMPD2_ENST00000407470.4_Missense_Mutation_p.S907L|FRMPD2_ENST00000305531.3_Missense_Mutation_p.S914L|FRMPD2_ENST00000463706.1_5'UTR	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	939					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		TTCTGGAGGTGATGGAGGACA	0.423000													12	27					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191051	6191051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6191051G>A	ENST00000530810.1	-	1	587	c.506C>T	c.(505-507)cCc>cTc	p.P169L	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGGCAGAAGGGCAGCCGCTT	0.502000													4	36					0	0	1	0	0
VOPP1	81552	broad.mit.edu	37	7	55565375	55565375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55565375G>A	ENST00000285279.5	-	3	322	c.122C>T	c.(121-123)tCc>tTc	p.S41F	VOPP1_ENST00000433959.1_Missense_Mutation_p.S32F|VOPP1_ENST00000454227.1_Intron|VOPP1_ENST00000453256.1_5'UTR|VOPP1_ENST00000428097.1_5'UTR|VOPP1_ENST00000471168.1_5'UTR|VOPP1_ENST00000428648.1_5'UTR|VOPP1_ENST00000545390.1_Missense_Mutation_p.S38F|VOPP1_ENST00000418904.1_Missense_Mutation_p.S24F|VOPP1_ENST00000427700.1_Missense_Mutation_p.S39F	NM_030796.3	NP_110423.3	Q96AW1	VOPP1_HUMAN	vesicular, overexpressed in cancer, prosurvival protein 1	41					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity			endometrium(1)|lung(4)	5						GTCCTCGTAGGAGCGGCATCT	0.592000													25	51					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100530112	100530112	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100530112C>T	ENST00000457717.1	+	13	2003	c.1747C>T	c.(1747-1749)Cta>Tta	p.L583L	MTTP_ENST00000265517.5_Silent_p.L583L|MTTP_ENST00000511045.1_Silent_p.L610L|RP11-766F14.1_ENST00000508578.1_RNA	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	583	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TCAAGACATCCTACGTTTTGA	0.403000													30	110					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566685	136566685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136566685C>T	ENST00000264162.2	-	8	3242	c.3232G>A	c.(3232-3234)Gaa>Aaa	p.E1078K		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1078	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGGGGAAATTCCCCTGAGCCA	0.507000													16	28					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646362	57646362	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57646362C>T	ENST00000269834.1	-	5	1728	c.1343G>A	c.(1342-1344)gGa>gAa	p.G448E		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCAGAACATCCATAAGGTTT	0.408000													51	165					0	0	1	0	0
TBC1D15	64786	broad.mit.edu	37	12	72316862	72316862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72316862C>T	ENST00000550746.1	+	18	2018	c.1954C>T	c.(1954-1956)Cct>Tct	p.P652S	TBC1D15_ENST00000485960.2_Missense_Mutation_p.P635S|TBC1D15_ENST00000393309.3_Missense_Mutation_p.P406S|TBC1D15_ENST00000319106.8_Missense_Mutation_p.P643S	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	652							protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGTCATGACTCCTTGTCCTAC	0.473000													49	121					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220353814	220353814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220353814G>A	ENST00000312358.7	+	35	8320	c.8188G>A	c.(8188-8190)Gac>Aac	p.D2730N	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2730	Fibronectin type-III 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGGCATCCCCGACTGTTACTA	0.632000													43	71					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121228689	121228689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121228689G>A	ENST00000297848.3	+	14	1967	c.1697G>A	c.(1696-1698)cGa>cAa	p.R566Q	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.R471Q|COL14A1_ENST00000309791.4_Missense_Mutation_p.R566Q	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	566	Fibronectin type-III 4.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATGGTTATCGAATTGTATAT	0.403000													37	91					0	0	1	0	0
FBXW9	84261	broad.mit.edu	37	19	12802014	12802014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12802014G>A	ENST00000380339.3	-	5	885	c.849C>T	c.(847-849)acC>acT	p.T283T	FBXW9_ENST00000393261.3_Silent_p.T283T|FBXW9_ENST00000544494.1_Silent_p.T21T|FBXW9_ENST00000587955.1_Silent_p.T273T			Q5XUX1	FBXW9_HUMAN	F-box and WD repeat domain containing 9	283							protein binding			cervix(1)|lung(4)|ovary(1)|prostate(1)	7						TCTTGTCATAGGTGCCAGTCA	0.607000													39	112					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769146	57769146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57769146G>A	ENST00000371030.2	+	1	3072	c.3072G>A	c.(3070-3072)ggG>ggA	p.G1024G		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1024						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AGTTGGGGGGGGACAAGGGGG	0.682000													10	17					0	0	1	0	0
NPHP1	4867	broad.mit.edu	37	2	110901148	110901148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:110901148G>A	ENST00000316534.4	-	16	1741	c.1668C>T	c.(1666-1668)tcC>tcT	p.S556S	NPHP1_ENST00000417665.1_Silent_p.S499S|NPHP1_ENST00000393272.3_Silent_p.S555S|NPHP1_ENST00000355301.4_Silent_p.S437S|NPHP1_ENST00000445609.2_Silent_p.S500S			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	555					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						TTCTGTTCAAGGATCTCAGTT	0.413000													7	100					0	0	1	0	0
TPTEP1	387590	broad.mit.edu	37	22	17119611	17119611	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17119611C>T	ENST00000426585.1	+	0	423																											GGATGTTCTTCTTCGAGTATT	0.358000													21	48					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56244352	56244352	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56244352T>C	ENST00000332836.2	-	2	872	c.845A>G	c.(844-846)aAa>aGa	p.K282R		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	282	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AAAATAGTGTTTTTGCATAGC	0.403000													28	71					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055529	75055529	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75055529C>T	ENST00000326665.5	-	12	2180	c.1962G>A	c.(1960-1962)gtG>gtA	p.V654V	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Silent_p.V457V	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	654	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GCTTGGTCTCCACATCTGCTT	0.398000													21	95					0	0	1	0	0
C11orf74	119710	broad.mit.edu	37	11	36654959	36654959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:36654959C>T	ENST00000446510.2	+	3	361	c.262C>T	c.(262-264)Cgt>Tgt	p.R88C	C11orf74_ENST00000334307.5_Missense_Mutation_p.R88C|C11orf74_ENST00000534635.1_Intron|C11orf74_ENST00000347206.4_Intron			Q86VG3	CK074_HUMAN	chromosome 11 open reading frame 74	88										breast(1)|kidney(1)|large_intestine(1)|lung(5)	8	all_lung(20;0.226)	all_hematologic(20;0.0118)				CATCTTTCTTCGTACTTCATC	0.308000													10	37					0	0	1	0	0
TLK2	11011	broad.mit.edu	37	17	60631029	60631029	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60631029C>T	ENST00000582809.1	+	10	889	c.186C>T	c.(184-186)gaC>gaT	p.D62D	TLK2_ENST00000542523.1_Silent_p.D179D|TLK2_ENST00000326270.9_Silent_p.D211D|TLK2_ENST00000346027.5_Silent_p.D211D|TLK2_ENST00000343388.7_Silent_p.D179D			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	211					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						TGTAGTCCGACCTCACAATAG	0.348000													22	76					0	0	1	0	0
GPRC5C	55890	broad.mit.edu	37	17	72443165	72443165	+	Nonstop_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72443165T>G	ENST00000392627.1	+	4	2585	c.1459T>G	c.(1459-1461)Tga>Gga	p.*487G	GPRC5C_ENST00000392629.2_Nonstop_Mutation_p.*454G|GPRC5C_ENST00000481232.1_3'UTR|GPRC5C_ENST00000582873.1_3'UTR|GPRC5C_ENST00000342648.5_Nonstop_Mutation_p.*127G	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	0						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						CGTGTGGGACTGAGTCAGCGG	0.667000													30	84					0	0	1	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6529206	6529206	+	Silent	SNP	C	C	T	rs79066520	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6529206C>T	ENST00000377748.1	-	20	2873	c.2376G>A	c.(2374-2376)gaG>gaA	p.E792E	PLEKHG5_ENST00000400913.1_Silent_p.E715E|PLEKHG5_ENST00000377732.1_Silent_p.E752E|PLEKHG5_ENST00000377728.3_Silent_p.E715E|PLEKHG5_ENST00000377740.3_Silent_p.E792E|PLEKHG5_ENST00000535355.1_Silent_p.E784E|PLEKHG5_ENST00000377737.2_Silent_p.E715E|PLEKHG5_ENST00000377725.1_Silent_p.E715E|PLEKHG5_ENST00000340850.5_Silent_p.E715E|PLEKHG5_ENST00000544978.1_Silent_p.E715E|PLEKHG5_ENST00000537245.1_Silent_p.E794E|PLEKHG5_ENST00000400915.3_Silent_p.E771E	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	771					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		cctcctcctcctcttcctcct	0.637000													17	72					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9101810	9101810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9101810G>A	ENST00000377414.3	-	5	672	c.605C>T	c.(604-606)cCc>cTc	p.P202L	SLC2A5_ENST00000535586.1_Intron|SLC2A5_ENST00000377424.4_Intron|SLC2A5_ENST00000536305.1_Intron	NM_001135585.1	NP_001129057.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	35				P -> G (in Ref. 2; AAB60641).	carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGGTGAAGGGGTGGGGGTG	0.542000													11	47					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44640922	44640922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44640922G>A	ENST00000372330.3	+	7	1163	c.1144G>A	c.(1144-1146)Gac>Aac	p.D382N		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	382	Fibronectin type-II 3.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CTTTGACAGCGACAAGAAGTG	0.667000													36	83					0	0	1	0	0
PI16	221476	broad.mit.edu	37	6	36930864	36930864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36930864C>T	ENST00000373674.3	+	5	1074	c.746C>T	c.(745-747)tCa>tTa	p.S249L	PI16_ENST00000491324.1_Intron	NM_001199159.1|NM_153370.2	NP_001186088.1|NP_699201.2	Q6UXB8	PI16_HUMAN	peptidase inhibitor 16	249						extracellular region|integral to membrane	peptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACAGAGGTCTCAGGCTCCCTG	0.577000													9	155					0	0	1	0	0
GPR162	27239	broad.mit.edu	37	12	6933226	6933226	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6933226C>T	ENST00000311268.3	+	2	949	c.162C>T	c.(160-162)ttC>ttT	p.F54F	GPR162_ENST00000428545.2_Intron|GPR162_ENST00000541431.1_3'UTR|GPR162_ENST00000382315.3_Intron	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	54						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						TGCTCTGCTTCCTAGCGGGCA	0.612000													6	38					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38592720	38592720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38592720C>T	ENST00000413689.1	-	28	5336	c.5143G>A	c.(5143-5145)Ggc>Agc	p.G1715S	SCN5A_ENST00000423572.2_Missense_Mutation_p.G1714S|SCN5A_ENST00000425664.1_Missense_Mutation_p.G1697S|SCN5A_ENST00000455624.2_Missense_Mutation_p.G1682S|SCN5A_ENST00000450102.2_Missense_Mutation_p.G1661S|SCN5A_ENST00000449557.2_Missense_Mutation_p.G1661S|SCN5A_ENST00000414099.2_Missense_Mutation_p.G1697S|SCN5A_ENST00000451551.2_Missense_Mutation_p.G1661S|SCN5A_ENST00000333535.4_Missense_Mutation_p.G1715S|SCN5A_ENST00000443581.1_Missense_Mutation_p.G1714S	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1715					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CTGAGGAGGCCATCCCAGCCG	0.642000													38	108					0	0	1	0	0
NRM	11270	broad.mit.edu	37	6	30658642	30658642	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30658642C>T	ENST00000259953.4	-	2	461	c.110G>A	c.(109-111)gGg>gAg	p.G37E	NRM_ENST00000470733.1_5'UTR|NRM_ENST00000376421.5_Missense_Mutation_p.G37E|NRM_ENST00000376420.5_Missense_Mutation_p.G37E	NM_001270707.1	NP_001257636.1	Q8IXM6	NRM_HUMAN	nurim (nuclear envelope membrane protein)	37						integral to membrane|nuclear inner membrane				large_intestine(1)|lung(2)	3						CTCCGGGATCCCTCCAAGAAG	0.632000													35	164					0	0	1	0	0
UBL3	5412	broad.mit.edu	37	13	30351346	30351346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:30351346G>A	ENST00000380680.4	-	2	1227	c.82C>T	c.(82-84)Cct>Tct	p.P28S		NM_007106.3	NP_009037.1	O95164	UBL3_HUMAN	ubiquitin-like 3	28	Ubiquitin-like.			P -> H (in Ref. 5; AAH44582).		intracellular|plasma membrane				large_intestine(3)|lung(1)	4		Lung SC(185;0.0281)		all cancers(112;0.0598)|GBM - Glioblastoma multiforme(144;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.147)		GAATCGTTAGGAGAAAACAGG	0.318000													8	80					0	0	1	0	0
TAL1	6886	broad.mit.edu	37	1	47685725	47685725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47685725C>T	ENST00000371883.3	-	4	1245	c.669G>A	c.(667-669)aaG>aaA	p.K223K	TAL1_ENST00000459729.1_5'UTR|TAL1_ENST00000294339.3_Silent_p.K221K|TAL1_ENST00000371884.2_Silent_p.K221K			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	221	Helix-loop-helix motif.				basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						TGCTGAGCTTCTTGTCCGGGG	0.597000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								13	68					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7091658	7091658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7091658G>A	ENST00000299481.4	+	11	3463	c.3117G>A	c.(3115-3117)aaG>aaA	p.K1039K		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	1039					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AAGTCTTGAAGTCTCCTAAGT	0.388000													35	60					0	0	1	0	0
GJA10	84694	broad.mit.edu	37	6	90604284	90604284	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:90604284C>T	ENST00000369352.1	+	1	97	c.97C>T	c.(97-99)Cga>Tga	p.R33*		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	33					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		CTTCATCTTCCGAATGCTGGT	0.507000													54	58					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29056049	29056049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29056049C>T	ENST00000257189.4	+	16	2909	c.2826C>T	c.(2824-2826)tcC>tcT	p.S942S		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	942					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTTCTGGTTCCCTCGTGCAAC	0.507000													31	106					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4201467	4201467	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4201467C>T	ENST00000404826.2	+	32	4918	c.4779C>T	c.(4777-4779)tcC>tcT	p.S1593S	SDK1_ENST00000389531.3_Silent_p.S1593S	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1593	Fibronectin type-III 10.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACACCACGTCCTCTGTCCTGA	0.562000													44	116					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81738458	81738458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81738458C>T	ENST00000550584.2	-	18	2542	c.2247G>A	c.(2245-2247)agG>agA	p.R749R	PPFIA2_ENST00000333447.7_Silent_p.R731R|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Silent_p.R731R|PPFIA2_ENST00000541570.2_Silent_p.R316R|PPFIA2_ENST00000541017.1_5'UTR|PPFIA2_ENST00000552948.1_Silent_p.R749R|PPFIA2_ENST00000548586.1_Silent_p.R749R|PPFIA2_ENST00000407050.4_Silent_p.R675R|PPFIA2_ENST00000550359.2_Silent_p.R596R|PPFIA2_ENST00000443686.3_Silent_p.R650R|PPFIA2_ENST00000549396.1_Silent_p.R749R	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	675										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TCCGATGTTTCCTCAGATCAC	0.284000													5	5					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140481402	140481402	+	Missense_Mutation	SNP	C	C	T	rs121913358		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:140481402C>T	ENST00000288602.6	-	11	1466	c.1406G>A	c.(1405-1407)gGa>gAa	p.G469E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	469	Protein kinase.		G -> A (in NHL; also in a lung adenocarcinoma sample; somatic mutation; elevated kinase activity; efficiently induces cell transformation).|G -> E (in CFC syndrome and colon cancer).|G -> R (in NHL).|G -> V (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G469A(19)|p.G469V(13)|p.G469S(5)|p.G469E(5)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GTAGACTGTTCCAAATGATCC	0.373000	G469A(NCIH1395_LUNG)|G469A(NCIH1755_LUNG)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				31	146					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507520	74507520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:74507520C>T	ENST00000354431.4	-	7	1286	c.1095G>A	c.(1093-1095)aaG>aaA	p.K365K	LRRIQ3_ENST00000395089.1_Silent_p.K365K	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	365										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						CTGCATTATTCTTCAATGAAC	0.338000													22	72					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119892174	119892174	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119892174C>T	ENST00000464295.1	-	9	1522	c.1077G>A	c.(1075-1077)gaG>gaA	p.E359E	GPR156_ENST00000461057.1_Silent_p.E355E|GPR156_ENST00000315843.3_Silent_p.E359E			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	359						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		TGAGGAGCCTCTCCATGGAGC	0.527000													21	54					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92102891	92102891	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92102891G>A	ENST00000256343.3	-	17	1776	c.1620C>T	c.(1618-1620)gcC>gcT	p.A540A		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	540					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TGTGCTGTGGGGCAAGCGCAG	0.378000													18	55					0	0	1	0	0
DGKE	8526	broad.mit.edu	37	17	54925375	54925375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54925375G>A	ENST00000284061.3	+	5	1017	c.837G>A	c.(835-837)ggG>ggA	p.G279G		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	279	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					TTTGTGGAGGGGATGGGACTG	0.398000													16	77					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149878254	149878254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149878254C>T	ENST00000369146.3	-	11	2323	c.1833G>A	c.(1831-1833)ggG>ggA	p.G611G	SV2A_ENST00000369145.1_Silent_p.G611G	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	611				G -> R (in Ref. 3; BAC11645).	neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ACACGATATTCCCAGGAAGCA	0.577000													17	75					0	0	1	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153312970	153312970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153312970G>A	ENST00000368739.3	-	7	1057	c.699C>T	c.(697-699)atC>atT	p.I233I	PGLYRP4_ENST00000359650.5_Silent_p.I237I			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	237					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGTGGATAATGATGCCATACT	0.597000													25	65					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3782725	3782725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:3782725C>T	ENST00000440314.2	-	7	1031	c.558G>A	c.(556-558)ctG>ctA	p.L186L	EFCAB4B_ENST00000444507.1_Silent_p.L186L|EFCAB4B_ENST00000252322.1_Silent_p.L186L	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	186					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			CCTCCTTCTTCAGCTGCAACC	0.493000													33	69					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671554	39671554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39671554C>T	ENST00000398930.1	+	4	725	c.371C>T	c.(370-372)tCc>tTc	p.S124F	KCNJ15_ENST00000328656.3_Missense_Mutation_p.S124F|KCNJ15_ENST00000398934.1_Missense_Mutation_p.S124F|KCNJ15_ENST00000398932.1_Missense_Mutation_p.S124F|KCNJ15_ENST00000398938.2_Missense_Mutation_p.S124F			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	124					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						TCCCTGGAATCCCAGACAACC	0.498000													31	101					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35700677	35700677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35700677C>T	ENST00000440995.2	+	16	2206	c.2206C>T	c.(2206-2208)Ctt>Ttt	p.L736F	SPEF2_ENST00000356031.3_Missense_Mutation_p.L741F|CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000509059.1_Missense_Mutation_p.L736F			Q9C093	SPEF2_HUMAN	sperm flagellar 2	741					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGAAGAAGCTCTTACAGGCTG	0.398000													20	61					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50530608	50530608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50530608G>A	ENST00000374144.3	+	3	306	c.18G>A	c.(16-18)aaG>aaA	p.K6K	C10orf71_ENST00000323868.4_Silent_p.K6K			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	6										endometrium(1)	1						AAGGAAATAAGAAGTGCACAG	0.537000													4	13					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38750845	38750845	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38750845C>T	ENST00000359357.3	+	15	1928	c.1674C>T	c.(1672-1674)tcC>tcT	p.S558S	DNAH8_ENST00000449981.2_Silent_p.S775S|DNAH8_ENST00000441566.1_Silent_p.S558S					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACAAGATCTCCTATGTGCTGG	0.403000													24	55					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47532341	47532341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47532341C>T	ENST00000300527.4	+	3	668	c.564C>T	c.(562-564)ttC>ttT	p.F188F	COL6A2_ENST00000397763.1_Silent_p.F188F|COL6A2_ENST00000460886.1_3'UTR|COL6A2_ENST00000409416.1_Silent_p.F188F|COL6A2_ENST00000310645.5_Silent_p.F188F|COL6A2_ENST00000357838.4_Silent_p.F188F	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	188	Nonhelical region.|VWFA 1.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TCCGGCTCTTCGCCGTGGCCC	0.706000													5	20					0	0	1	0	0
CYTH1	9267	broad.mit.edu	37	17	76705812	76705812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76705812G>A	ENST00000446868.3	-	2	95	c.25C>T	c.(25-27)Ccc>Tcc	p.P9S	CYTH1_ENST00000585509.1_5'UTR|CYTH1_ENST00000589297.1_5'UTR|CYTH1_ENST00000589296.1_Missense_Mutation_p.P9S|CYTH1_ENST00000591455.1_Missense_Mutation_p.P9S|CYTH1_ENST00000361101.4_Missense_Mutation_p.P9S			Q15438	CYH1_HUMAN	cytohesin 1	9					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	19						AGGTCACTGGGAACTACAAAA	0.468000													23	71					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264273	155264273	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155264273C>T	ENST00000392414.3	-	6	985	c.872_splice	c.e6+1	p.R291_splice	PKLR_ENST00000342741.4_Splice_Site_p.R322_splice	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	322					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CAAGCCTCACCTCTTCACGCC	0.577000													27	60					0	0	1	0	0
AVIL	10677	broad.mit.edu	37	12	58196037	58196037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58196037C>T	ENST00000537081.1	-	16	2035	c.2036G>A	c.(2035-2037)cGa>cAa	p.R679Q	TSFM_ENST00000548851.1_Intron|AVIL_ENST00000257861.3_Missense_Mutation_p.R686Q|TSFM_ENST00000550559.1_Missense_Mutation_p.R218W|TSFM_ENST00000543727.1_Intron			O75366	AVIL_HUMAN	advillin	686	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GTCGGGATCTCGGCCGCTGGG	0.557000													19	26					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800940	185800940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185800940G>A	ENST00000302277.6	+	4	1411	c.817G>A	c.(817-819)Gag>Aag	p.E273K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	273						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GAGTTCTGAGGAGAAAACTAA	0.393000													26	103					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72004417	72004417	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72004417G>A	ENST00000294053.3	-	17	2291	c.2118C>T	c.(2116-2118)acC>acT	p.T706T	CLPB_ENST00000437826.2_Silent_p.T661T|CLPB_ENST00000538021.1_Silent_p.T314T|CLPB_ENST00000543042.1_Silent_p.T505T|CLPB_ENST00000340729.5_Silent_p.T647T|CLPB_ENST00000538039.1_Silent_p.T676T	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	706					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						GCTGCTAGATGGTGTTGCACA	0.592000													23	35					0	0	1	0	0
TIGD2	166815	broad.mit.edu	37	4	90035004	90035004	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:90035004C>T	ENST00000317005.2	+	1	1037	c.879C>T	c.(877-879)ttC>ttT	p.F293F		NM_145715.2	NP_663761.1	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	293	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	14		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		TTTTAGATTTCCCCCCAGCAC	0.393000													35	83					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18707817	18707817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18707817C>T	ENST00000392386.3	-	5	933	c.740G>A	c.(739-741)gGg>gAg	p.G247E		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	247	Fibronectin type-III 2.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						CTCCAGGCCCCCGACGCGGCT	0.662000													4	39					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878979	24878979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24878979C>T	ENST00000382554.3	+	4	2297	c.1979C>T	c.(1978-1980)tCc>tTc	p.S660F		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	660					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCTGCAGCTTCCAAAGCACCT	0.567000													4	22					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947463	237947463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237947463G>A	ENST00000366574.2	+	90	12768	c.12451G>A	c.(12451-12453)Gaa>Aaa	p.E4151K	RYR2_ENST00000360064.6_Missense_Mutation_p.E4157K|RYR2_ENST00000542537.1_Missense_Mutation_p.E4135K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4151					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTCTATTTTGAAATCAGTGA	0.498000													60	96					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306010	54306010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54306010G>A	ENST00000545554.1	+	1	910	c.910G>A	c.(910-912)Gac>Aac	p.D304N	UNC13C_ENST00000537900.1_Missense_Mutation_p.D304N|UNC13C_ENST00000260323.11_Missense_Mutation_p.D304N			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	304					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGAAACTAGAGACATCCATGA	0.428000													42	141					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127642053	127642053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127642053C>T	ENST00000405109.1	+	2	616	c.149C>T	c.(148-150)gCt>gTt	p.A50V	KBTBD12_ENST00000407609.3_Intron|KBTBD12_ENST00000405256.1_Missense_Mutation_p.A50V			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	50	BTB.									endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						CTGGTCCTGGCTGCATTTAGC	0.393000													21	47					0	0	1	0	0
SLC39A4	55630	broad.mit.edu	37	8	145642042	145642042	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145642042C>T	ENST00000301305.3	-	1	237	c.132G>A	c.(130-132)ctG>ctA	p.L44L		NM_130849.2	NP_570901.2	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter), member 4	44						cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	14	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			ACAGGCCGCCCAGAGCCTCTT	0.677000													5	17					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72775173	72775173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:72775173C>T	ENST00000299687.5	+	8	5496	c.5496C>T	c.(5494-5496)agC>agT	p.S1832S		NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1832					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGACAGACAGCCCCTTCACCG	0.622000													45	166					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	8987935	8987935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:8987935G>A	ENST00000344836.4	-	31	3427	c.3229C>T	c.(3229-3231)Cta>Tta	p.L1077L	USP7_ENST00000535863.1_Silent_p.L978L|USP7_ENST00000381886.4_Silent_p.L1061L	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	1077					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						TCGAGCCCTAGCCAAGGCCGA	0.522000													35	117					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134125848	134125848	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134125848G>A	ENST00000220616.4	+	44	7794		c.e44+1		TG_ENST00000377869.1_Splice_Site|TG_ENST00000519543.1_Splice_Site|TG_ENST00000542445.1_Splice_Site	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin						hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ATGCCACCCGGTAAGCTAAGC	0.532000													7	16					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155649647	155649647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155649647C>T	ENST00000496455.1	+	13	1989	c.1654C>T	c.(1654-1656)Cgc>Tgc	p.R552C	GMPS_ENST00000295920.7_Missense_Mutation_p.R453C	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	552					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCTTATACCTCGCATGTGTCA	0.438000			T	MLL	AML								56	171					0	0	1	0	0
LOC100505782	100505782	broad.mit.edu	37	17	39580838	39580838	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39580838G>A	ENST00000432258.1	+	0	3427																											CACTGAGACTGAAGCCTCCTC	0.572000													9	10					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114186370	114186370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114186370C>T	ENST00000369615.1	+	11	2034	c.1972C>T	c.(1972-1974)Cct>Tct	p.P658S	MAGI3_ENST00000369611.4_Missense_Mutation_p.P658S|MAGI3_ENST00000307546.9_Missense_Mutation_p.P658S|MAGI3_ENST00000369617.4_Missense_Mutation_p.P683S	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	683	PDZ 3.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTAAGGTCCTCCTTCACCAAC	0.393000													36	98					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26163834	26163834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:26163834G>A	ENST00000381655.2	+	24	2350	c.2208G>A	c.(2206-2208)ttG>ttA	p.L736L	ATP8A2_ENST00000255283.8_Silent_p.L696L|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	696					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGGACTCTTTGGATGTAAGTA	0.363000													30	90					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964887	70964887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70964887C>T	ENST00000357250.6	-	23	1735	c.1577G>A	c.(1576-1578)gGa>gAa	p.G526E	COL9A1_ENST00000370499.4_Missense_Mutation_p.G283E|COL9A1_ENST00000320755.7_Missense_Mutation_p.G283E|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	526	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						ACCAGGAATTCCTCTAGCACC	0.438000													55	90					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2375859	2375859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2375859C>T	ENST00000202625.2	+	3	262	c.201C>T	c.(199-201)gcC>gcT	p.A67A	TGM6_ENST00000381423.1_Silent_p.A67A|TGM6_ENST00000477505.1_Intron	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	67					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CTTCTGAGGCCCTCCACACCA	0.587000													8	27					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44685808	44685808	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44685808G>A	ENST00000454036.1	+	25	3270		c.e25-1		SLC12A5_ENST00000243964.3_Splice_Site	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5						potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCTGCCGCAGGAACCAGTCC	0.627000													10	61					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584754	1584754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1584754C>T	ENST00000381297.4	-	2	908	c.698G>A	c.(697-699)aGg>aAg	p.R233K		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	233						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACCGCGCGCCTCCGCTGCTC	0.662000			T	CRLF2	"""B-ALL, Downs associated ALL"""								11	18					0	0	1	0	0
TPSB2	64499	broad.mit.edu	37	16	1279235	1279235	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1279235C>T	ENST00000430512.2	-	0	505				TPSB2_ENST00000445910.1_RNA|TPSB2_ENST00000339687.6_RNA	NM_024164.5	NP_077078.5	P20231	TRYB2_HUMAN	tryptase beta 2 (gene/pseudogene)						proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			lung(1)|upper_aerodigestive_tract(1)	2		Hepatocellular(780;0.00369)				GCACGGCATCCCCGGGGGGGA	0.682000													6	9					0	0	1	0	0
ZPBP	11055	broad.mit.edu	37	7	50097645	50097645	+	Missense_Mutation	SNP	C	C	T	rs148913753		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50097645C>T	ENST00000046087.2	-	4	496	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	ZPBP_ENST00000419417.1_Missense_Mutation_p.E142K	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	143					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					GGTTTATATTCGAGGAAACAT	0.328000													19	64					0	0	1	0	0
IGSF3	3321	broad.mit.edu	37	1	117122373	117122373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:117122373G>A	ENST00000369486.3	-	10	3740	c.2975C>T	c.(2974-2976)tCc>tTc	p.S992F	IGSF3_ENST00000318837.6_Missense_Mutation_p.S1012F|IGSF3_ENST00000369483.1_Missense_Mutation_p.S1012F	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	992	Ig-like C2-type 8.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AGTCCTCAGGGAATACCAGGC	0.612000													15	39					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75408259	75408259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75408259G>A	ENST00000394810.2	-	4	1300	c.1151C>T	c.(1150-1152)tCt>tTt	p.S384F	SYNPO2L_ENST00000372873.4_Missense_Mutation_p.S160F|SYNPO2L_ENST00000372872.4_Missense_Mutation_p.S384F	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	384						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					CCCTCGCCCAGAGACCTCACT	0.647000													19	88					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45484726	45484726	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45484726C>T	ENST00000334940.6	+	7	697	c.563C>T	c.(562-564)tCc>tTc	p.S188F	RASSF4_ENST00000472561.1_3'UTR|RASSF4_ENST00000340258.4_Missense_Mutation_p.S179F|RASSF4_ENST00000374417.2_3'UTR			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	179	Ras-associating.				cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						GTACAGACCTCCGTGTTTACT	0.547000													14	37					0	0	1	0	0
LMOD1	25802	broad.mit.edu	37	1	201869723	201869723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201869723C>T	ENST00000367288.4	-	2	664	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K		NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	140					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CCACCAGCTTCATCTCTGTCT	0.562000													67	206					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71602146	71602146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71602146G>A	ENST00000355962.4	-	12	1399	c.1266C>T	c.(1264-1266)gtC>gtT	p.V422V	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	422					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	TCACCTCGGGGACTGTGATGA	0.512000													5	50					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155450997	155450997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155450997G>A	ENST00000461783.3	+	6	1913	c.640G>A	c.(640-642)Gcc>Acc	p.A214T	TIAM2_ENST00000456144.1_Missense_Mutation_p.A214T|TIAM2_ENST00000318981.5_Missense_Mutation_p.A214T|TIAM2_ENST00000360366.4_Missense_Mutation_p.A214T|TIAM2_ENST00000529824.2_Missense_Mutation_p.A214T|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	214					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGTGCCTGAAGCCAGGAGGGG	0.637000													24	26					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7607462	7607462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7607462C>T	ENST00000221249.6	+	14	1582	c.1151C>T	c.(1150-1152)cCc>cTc	p.P384L	PNPLA6_ENST00000450331.3_Missense_Mutation_p.P384L|PNPLA6_ENST00000414982.3_Missense_Mutation_p.P432L|PNPLA6_ENST00000545201.2_Missense_Mutation_p.P384L|PNPLA6_ENST00000600737.1_Missense_Mutation_p.P423L	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	423					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						CAGGGTGGCCCCCGCTCCGAC	0.607000													9	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179631337	179631337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179631337G>A	ENST00000589042.1	-	41	9698	c.9474C>T	c.(9472-9474)gtC>gtT	p.V3158V	TTN_ENST00000342992.6_Silent_p.V3158V|TTN_ENST00000360870.5_Silent_p.V3158V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V3112V|TTN_ENST00000342175.6_Silent_p.V3112V|TTN_ENST00000359218.5_Silent_p.V3112V|TTN_ENST00000591111.1_Silent_p.V3158V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2893							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTCTCAATGACCTGTTGAT	0.368000													14	43					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116049295	116049295	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116049295C>T	ENST00000603594.1	+	12	2490	c.2169C>T	c.(2167-2169)ccC>ccT	p.P723P	VWA2_ENST00000392982.3_Intron	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	0	EGF-like 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		ATGGCAGGCCCTCAGCCTGAG	0.597000													16	38					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024624	76024624	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76024624C>T	ENST00000393004.2	-	5	1145	c.924G>A	c.(922-924)tcG>tcA	p.S308S	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Silent_p.S308S|FILIP1_ENST00000370020.1_Silent_p.S209S			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	308										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GAGAAAACCTCGAAGCCTTGT	0.418000													40	60					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057714	63057714	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63057714C>T	ENST00000332793.6	+	1	79	c.77C>T	c.(76-78)cCc>cTc	p.P26L	SLC22A10_ENST00000544661.1_Intron|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	26						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTTATTCTTCCCTCTCTCATG	0.458000													26	49					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36259149	36259149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36259149C>T	ENST00000394571.2	+	2	258	c.258C>T	c.(256-258)ttC>ttT	p.F86F	PNPLA1_ENST00000388715.3_5'UTR|PNPLA1_ENST00000312917.5_5'UTR	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	86	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						AGAAATCCTTCCTGGGGCCCT	0.592000													19	51					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121428052	121428052	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121428052C>T	ENST00000260197.7	+	19	2730	c.2601C>T	c.(2599-2601)ctC>ctT	p.L867L		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	867					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ACTTCCGACTCACAATCGTCA	0.527000													34	106					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6702214	6702214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6702214C>T	ENST00000245907.6	-	19	2456	c.2364G>A	c.(2362-2364)acG>acA	p.T788T		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	788					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding	p.T788T(1)		breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TCATGAGCTTCGTAGAGATTC	0.512000													14	60					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57013143	57013143	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:57013143C>T	ENST00000370706.4	+	10	2504	c.2260C>T	c.(2260-2262)Cgc>Tgc	p.R754C	RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Missense_Mutation_p.R754C|RP11-203B9.4_ENST00000589549.1_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.R754C|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	754					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ACTGTGGTTTCGCTGCAGTTT	0.413000													6	33					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111616007	111616007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:111616007G>A	ENST00000261486.5	-	3	494	c.218C>T	c.(217-219)cCt>cTt	p.P73L		NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	73	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		GGTTTTTGCAGGATCCAGCCA	0.333000													42	228					0	0	1	0	0
TMEM56	148534	broad.mit.edu	37	1	95657146	95657146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:95657146G>A	ENST00000370203.4	+	7	805	c.514G>A	c.(514-516)Gct>Act	p.A172T	RP11-57H12.3_ENST00000419846.1_RNA|RP11-57H12.6_ENST00000604534.1_Intron|RP11-57H12.3_ENST00000421762.1_RNA	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56	172	TLC.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		GTTTTCTAAAGCTATCGTTAT	0.368000													51	123					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121996	38121996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38121996G>A	ENST00000406386.3	+	7	3688	c.3433G>A	c.(3433-3435)Gag>Aag	p.E1145K	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1145					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GGCCAGCACAGAGAGCCTTGT	0.642000													45	128					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156635959	156635959	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156635959G>A	ENST00000422843.3	+	2	350	c.198G>A	c.(196-198)gtG>gtA	p.V66V	CTB-4E7.1_ENST00000519375.1_RNA	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	66	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGAGATTGTGAAAAGTGACA	0.463000			T	SYK	peripheral T-cell lymphoma								8	54					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28378638	28378638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28378638C>T	ENST00000337532.5	-	13	1361	c.1085G>A	c.(1084-1086)cGa>cAa	p.R362Q	MPP7_ENST00000540098.1_Missense_Mutation_p.R362Q|MPP7_ENST00000375719.3_Missense_Mutation_p.R362Q|MPP7_ENST00000445954.2_Missense_Mutation_p.R237Q|MPP7_ENST00000375732.1_Missense_Mutation_p.R362Q	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	362					establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						ATTAGTTTGTCGCCGATACGG	0.388000													73	215					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111748007	111748007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111748007G>A	ENST00000261726.6	+	15	1575	c.1421G>A	c.(1420-1422)cGg>cAg	p.R474Q		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	474	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R474Q(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GACGGCACTCGGACTTTCTCG	0.697000													4	12					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170406	58170406	+	Silent	SNP	C	C	T	rs141530938		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58170406C>T	ENST00000309403.2	-	1	476	c.477G>A	c.(475-477)ggG>ggA	p.G159G		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G159G(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TAAATGTGTCCCCAGTGTGGA	0.453000													26	134					0	0	1	0	0
TATDN2	9797	broad.mit.edu	37	3	10291286	10291286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10291286C>T	ENST00000287652.4	+	2	1453	c.402C>T	c.(400-402)gcC>gcT	p.A134A	TATDN2_ENST00000448281.2_Silent_p.A134A|RP11-438J1.1_ENST00000450534.1_Silent_p.A77A	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	134						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						AGGAGGAAGCCTGCAGCCTTA	0.562000													13	52					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101839977	101839977	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101839977C>T	ENST00000360264.3	+	15	1339	c.1319C>T	c.(1318-1320)cCc>cTc	p.P440L	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000556210.1_Intron|CUX1_ENST00000550008.2_Missense_Mutation_p.P429L|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292535.7_Missense_Mutation_p.P429L|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000546411.2_Intron|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000549414.2_Missense_Mutation_p.P429L	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	429					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TTGCCGGCCCCCCCTCCTTCT	0.567000													34	87					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107019950	107019950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:107019950G>A	ENST00000369063.3	-	9	1577	c.1112C>T	c.(1111-1113)cCt>cTt	p.P371L	RTN4IP1_ENST00000539449.1_3'UTR|RTN4IP1_ENST00000498091.1_5'UTR	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	371						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		TTTAGAAAAAGGAAAGGTTTG	0.378000													24	46					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31474869	31474869	+	Silent	SNP	C	C	T	rs143678527	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31474869C>T	ENST00000252229.6	+	4	763	c.684C>T	c.(682-684)tcC>tcT	p.S228S	MICB_ENST00000538442.1_Silent_p.S196S|MICB_ENST00000399150.3_Silent_p.S185S	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	228	Ig-like C1-type.				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						GCAGGGCTTCCAGCTTCTATC	0.577000													15	51					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62774377	62774377	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62774377G>A	ENST00000400873.3	-	0	1019					NR_026899.1																						CGCGGCTGGGGAGAGGGAGCT	0.612000													3	9					0	0	1	0	0
EMC2	9694	broad.mit.edu	37	8	109498750	109498750	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:109498750C>T	ENST00000220853.3	+	11	852	c.817C>T	c.(817-819)Cga>Tga	p.R273*	EMC2_ENST00000520294.1_3'UTR	NM_014673.3	NP_055488.1			ER membrane protein complex subunit 2									p.R273*(1)									GTTTGCAGGTCGAAGTAAGAA	0.333000													14	36					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814347	242814347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242814347G>A	ENST00000343216.3	+	2	668	c.640G>A	c.(640-642)Gac>Aac	p.D214N		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	214						integral to membrane											TACCAGCAATGACCAGGTGCC	0.667000													19	31					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80419559	80419559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:80419559C>T	ENST00000265080.4	+	16	2636	c.2569C>T	c.(2569-2571)Cgg>Tgg	p.R857W		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	857					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CTCAACTCCTCGGCACCTCCG	0.532000													17	48					0	0	1	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133918355	133918355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:133918355G>A	ENST00000298622.4	+	1	181	c.43G>A	c.(43-45)Gca>Aca	p.A15T		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GGGGGACAAGGCAGAGGCCCT	0.677000													4	6					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2890665	2890665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:2890665C>T	ENST00000380698.4	-	7	952	c.863G>A	c.(862-864)gGa>gAa	p.G288E		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	288					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				ATCAACAATTCCCAAATGCCG	0.463000													37	111					0	0	1	0	0
DUSP10	11221	broad.mit.edu	37	1	221912437	221912437	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:221912437G>A	ENST00000366899.3	-	2	888	c.650C>T	c.(649-651)tCc>tTc	p.S217F	DUSP10_ENST00000323825.3_Intron	NM_007207.4	NP_009138.1	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10	217	Rhodanese.				inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			NS(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(131;0.0103)		TTCCCTACAGGAAATCAAGTC	0.468000													17	71					0	0	1	0	0
NRN1L	123904	broad.mit.edu	37	16	67920138	67920138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67920138C>T	ENST00000576147.1	+	2	548	c.254C>T	c.(253-255)cCt>cTt	p.P85L	CTC-479C5.10_ENST00000572067.1_RNA|NRN1L_ENST00000339176.3_Silent_p.A158A			Q496H8	NRN1L_HUMAN	neuritin 1-like	0						anchored to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		TGGCTCTGGCCTACCTCCTGA	0.682000													5	16					0	0	1	0	0
TRBV30	28557	broad.mit.edu	37	7	142510528	142510528	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142510528C>T	ENST00000417977.2	-	0	189																											GCACCAGGGTCGCTGGCCATT	0.577000													4	13					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7984041	7984041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7984041G>A	ENST00000319144.4	-	5	845	c.585C>T	c.(583-585)ttC>ttT	p.F195F	AC129492.6_ENST00000399413.3_3'UTR	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	195	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						TTAAGTTCAGGAACTTGGTGG	0.577000										Multiple Myeloma(8;0.094)	OREG0024153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	75					0	0	1	0	0
CCDC146	57639	broad.mit.edu	37	7	76908153	76908153	+	Missense_Mutation	SNP	C	C	T	rs144226591	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76908153C>T	ENST00000285871.4	+	12	1652	c.1525C>T	c.(1525-1527)Cgg>Tgg	p.R509W	CCDC146_ENST00000431197.1_Missense_Mutation_p.R223W|CCDC146_ENST00000415740.2_3'UTR	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	509										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TGAAATTTATCGGAGGTAAAG	0.303000													5	31					0	0	1	0	0
TRAV26-2	28656	broad.mit.edu	37	14	22671253	22671253	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22671253C>T	ENST00000390460.1	+	0	318																											ACTACTGCATCCTGAGAGACC	0.527000													4	35					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185146729	185146729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185146729C>T	ENST00000265026.3	+	2	694	c.360C>T	c.(358-360)ttC>ttT	p.F120F	MAP3K13_ENST00000446828.1_Intron|MAP3K13_ENST00000443863.1_Intron|MAP3K13_ENST00000535426.1_Intron|MAP3K13_ENST00000424227.1_Silent_p.F120F	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	120					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGATTCAGTTCAGCAGGTCAG	0.488000													22	63					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45711070	45711070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45711070C>T	ENST00000291582.5	+	8	1099	c.972C>T	c.(970-972)tcC>tcT	p.S324S	AIRE_ENST00000355347.4_Silent_p.S117S|AIRE_ENST00000329347.4_Silent_p.S117S	NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	324					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		CCTGCCTGTCCCCTCCGCTCC	0.682000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				10	30					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46365631	46365631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:46365631G>A	ENST00000359930.4	-	3	1082	c.231C>T	c.(229-231)caC>caT	p.H77H	SULF2_ENST00000484875.1_Silent_p.H77H|SULF2_ENST00000467815.1_Silent_p.H77H|SULF2_ENST00000478766.1_5'UTR|SULF2_ENST00000361612.4_Silent_p.H77H	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	77					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CGTTGATGAAGTGCGCCCCGC	0.597000													7	75					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67039548	67039548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:67039548G>A	ENST00000315962.4	+	1	418	c.45G>A	c.(43-45)caG>caA	p.Q15Q	TRIM55_ENST00000350034.4_Silent_p.Q15Q|TRIM55_ENST00000276573.7_Silent_p.Q15Q|TRIM55_ENST00000353317.5_Silent_p.Q15Q	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	15						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			AAGAGCAGCAGACCATGGATA	0.502000													26	103					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88764104	88764104	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88764104C>T	ENST00000444431.1	+	0	2646				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GATACATCATCATATCACGGA	0.373000													100	235					0	0	1	0	0
CXCR2	3579	broad.mit.edu	37	2	219000422	219000422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219000422G>A	ENST00000318507.2	+	3	1325	c.898G>A	c.(898-900)Gag>Aag	p.E300K		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	300					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						GGATGCCACCGAGATTCTGGG	0.567000													31	104					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97150338	97150338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:97150338C>T	ENST00000524981.3	+	24	3296	c.3296C>T	c.(3295-3297)tCa>tTa	p.S1099L				Q6ZTY8	CL063_HUMAN		1073										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GATCAAAACTCAGGGTAAAAA	0.383000													6	18					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284537	52284537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52284537C>T	ENST00000301190.6	+	5	1034	c.807C>T	c.(805-807)ctC>ctT	p.L269L	ANKRD33_ENST00000538991.1_Silent_p.L75L|ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Silent_p.L144L	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	144										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		TGTCCGGGCTCGTggcccagg	0.677000													6	18					0	0	1	0	0
UBE3D	90025	broad.mit.edu	37	6	83728787	83728787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:83728787G>A	ENST00000369747.3	-	8	1037	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_198920.1	NP_944602.1	Q7Z6J8	UB2CB_HUMAN	ubiquitin protein ligase E3D	305						cytoplasm	ligase activity										CCAACAAGGGGAATTTTTTGA	0.378000													29	38					0	0	1	0	0
PRKG2	5593	broad.mit.edu	37	4	82027083	82027083	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:82027083G>A	ENST00000395578.1	-	16	2063	c.1947C>T	c.(1945-1947)ccC>ccT	p.P649P	PRKG2_ENST00000545647.1_Silent_p.P229P|PRKG2_ENST00000509169.1_5'UTR|PRKG2_ENST00000264399.1_Silent_p.P649P|PRKG2_ENST00000418486.2_Silent_p.P620P			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	649	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						CCCCAGAAAAGGGTGGGCTAG	0.398000													22	53					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55177268	55177268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55177268C>T	ENST00000391736.1	+	9	1075	c.760C>T	c.(760-762)Ctg>Ttg	p.L254L	LILRB4_ENST00000270452.2_Silent_p.L254L|LILRB4_ENST00000430952.2_Silent_p.L254L|LILRB4_ENST00000391733.3_Silent_p.L254L|LILRB4_ENST00000391734.3_Silent_p.L254L	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	254						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CGCCCAAGGTCTGAGAAGGCA	0.537000													4	10					0	0	1	0	0
MTERFD2	130916	broad.mit.edu	37	2	242039285	242039285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242039285G>A	ENST00000391980.2	-	2	104	c.46C>T	c.(46-48)Ccc>Tcc	p.P16S	MTERFD2_ENST00000407095.3_Missense_Mutation_p.P16S|MTERFD2_ENST00000495694.1_Missense_Mutation_p.P16S|MTERFD2_ENST00000406593.1_Intron	NM_182501.3	NP_872307.2	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	16										endometrium(3)|large_intestine(6)|lung(5)|ovary(1)|skin(2)|urinary_tract(3)	20		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		CAGGTGAGGGGGATCAGGCGG	0.498000													14	33					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42992800	42992800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42992800C>T	ENST00000253408.5	-	1	120	c.55G>A	c.(55-57)Gag>Aag	p.E19K	GFAP_ENST00000586793.1_Missense_Mutation_p.E19K|GFAP_ENST00000588735.1_Missense_Mutation_p.E19K|GFAP_ENST00000591327.1_5'UTR|GFAP_ENST00000435360.2_Missense_Mutation_p.E19K	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	19	Head.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				ACCATCATCTCCCCTGAGGAG	0.667000													6	9					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113285641	113285641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113285641G>A	ENST00000389385.4	+	5	721	c.224G>A	c.(223-225)cGa>cAa	p.R75Q	RPH3A_ENST00000551052.1_Missense_Mutation_p.R71Q|RPH3A_ENST00000548866.1_Intron|RPH3A_ENST00000420983.2_Missense_Mutation_p.R75Q|RPH3A_ENST00000447659.2_Intron|RPH3A_ENST00000543106.2_Missense_Mutation_p.R75Q|RPH3A_ENST00000415485.3_Missense_Mutation_p.R75Q	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	75	RabBD.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding	p.R71Q(1)		breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GAGCAGGAGCGAATCGGGTGA	0.562000													10	23					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108138014	108138014	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108138014C>T	ENST00000278616.4	+	17	2968	c.2583C>T	c.(2581-2583)taC>taT	p.Y861Y	ATM_ENST00000452508.2_Silent_p.Y861Y	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	861					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTAACGATTACCCTGATAGTA	0.368000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			22	66					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55268104	55268104	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55268104C>T	ENST00000275493.2	+	24	3121	c.2944C>T	c.(2944-2946)Cag>Tag	p.Q982*	EGFR_ENST00000454757.2_Nonsense_Mutation_p.Q929*|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_Nonsense_Mutation_p.Q937*	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	982					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCTTGTCATTCAGGTACAAAT	0.522000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			19	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179542591	179542591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179542591C>T	ENST00000589042.1	-	146	34272	c.34048G>A	c.(34048-34050)Gaa>Aaa	p.E11350K	TTN_ENST00000342992.6_Missense_Mutation_p.E10106K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E11033K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11033	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATAGAACTTCCTCTTCCTGA	0.393000													49	88					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2716282	2716282	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2716282C>T	ENST00000399655.1	+	26	3607	c.3342C>T	c.(3340-3342)ttC>ttT	p.F1114F	CACNA1C_ENST00000399637.1_Silent_p.F1114F|CACNA1C_ENST00000480911.1_Silent_p.F1114F|CACNA1C_ENST00000335762.5_Silent_p.F1139F|CACNA1C_ENST00000399603.1_Silent_p.F1114F|CACNA1C_ENST00000399649.1_Silent_p.F1114F|CACNA1C_ENST00000399595.1_Silent_p.F1114F|CACNA1C_ENST00000399606.1_Silent_p.F1134F|CACNA1C_ENST00000399601.1_Silent_p.F1114F|CACNA1C_ENST00000399617.1_Silent_p.F1114F|CACNA1C_ENST00000344100.3_Silent_p.F1114F|CACNA1C_ENST00000399621.1_Silent_p.F1114F|CACNA1C_ENST00000399629.1_Silent_p.F1114F|CACNA1C_ENST00000327702.7_Silent_p.F1114F|CACNA1C_ENST00000406454.3_Silent_p.F1114F|CACNA1C_ENST00000402845.3_Silent_p.F1114F|CACNA1C_ENST00000399597.1_Silent_p.F1114F|CACNA1C_ENST00000347598.4_Silent_p.F1134F|CACNA1C_ENST00000399641.1_Silent_p.F1114F|CACNA1C_ENST00000399638.1_Silent_p.F1114F|CACNA1C_ENST00000399644.1_Silent_p.F1114F|CACNA1C_ENST00000399591.1_Silent_p.F1114F|CACNA1C-AS3_ENST00000543559.1_RNA|CACNA1C_ENST00000399634.1_Silent_p.F1114F	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1134	Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCTCCACCTTCGAAGGGTGGC	0.537000													6	18					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147381070	147381070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:147381070G>A	ENST00000240986.4	+	2	1041	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	GJA8_ENST00000369235.1_Missense_Mutation_p.E330K	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	330					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					GGGGGCACAAGAAGTGGAGGG	0.617000													3	17					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46746655	46746655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:46746655G>A	ENST00000394809.4	-	10	2134	c.2019C>T	c.(2017-2019)ttC>ttT	p.F673F	MYLK3_ENST00000536476.1_Silent_p.F332F	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	673	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity	p.F673F(1)|p.F752F(1)		central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CAGGAGTGCCGAAGTTCACCT	0.547000													15	45					0	0	1	0	0
MFSD11	79157	broad.mit.edu	37	17	74772585	74772585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74772585G>A	ENST00000588460.1	+	12	3189	c.1147G>A	c.(1147-1149)Gac>Aac	p.D383N	MFSD11_ENST00000590070.1_3'UTR|MFSD11_ENST00000336509.4_Missense_Mutation_p.D383N|MFSD11_ENST00000590514.1_Missense_Mutation_p.D383N|MFSD11_ENST00000593181.1_Missense_Mutation_p.D331N|MFSD11_ENST00000586622.1_Missense_Mutation_p.D383N|MFSD11_ENST00000355954.3_Missense_Mutation_p.D331N	NM_001242534.1	NP_001229463.1	O43934	MFS11_HUMAN	major facilitator superfamily domain containing 11	383						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)	17						GTATTCTGAAGACAGCGCCCC	0.453000													48	169					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36122792	36122792	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:36122792G>A	ENST00000378660.1	+	8	1217	c.1029G>A	c.(1027-1029)tgG>tgA	p.W343*	CHDC2_ENST00000313548.4_Nonsense_Mutation_p.W343*					calponin homology domain containing 2																		ATGTGATATGGAAAAACTGTC	0.328000													7	34					0	0	1	0	0
NDST2	8509	broad.mit.edu	37	10	75567892	75567892	+	Silent	SNP	G	G	A	rs138811491		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75567892G>A	ENST00000309979.6	-	3	811	c.255C>T	c.(253-255)ccC>ccT	p.P85P	NDST2_ENST00000299641.4_5'UTR			P52849	NDST2_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	85	Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30	Prostate(51;0.0112)					CAAGGACCACGGGTTCAGTTC	0.602000													20	34					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089917	9089917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9089917G>A	ENST00000397910.4	-	1	2101	c.1898C>T	c.(1897-1899)tCa>tTa	p.S633L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	633	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCTCAGATGATGCTGTGGC	0.577000													20	80					0	0	1	0	0
PLIN3	10226	broad.mit.edu	37	19	4839365	4839365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4839365G>A	ENST00000221957.4	-	8	1320	c.1144C>T	c.(1144-1146)Ctg>Ttg	p.L382L	PLIN3_ENST00000592528.1_Silent_p.L370L|PLIN3_ENST00000585479.1_Silent_p.L381L	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	382					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	CTGCTGGACAGGTCCTGGAAG	0.647000													13	57					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182885	140182885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140182885C>T	ENST00000522353.2	+	1	2103	c.2103C>T	c.(2101-2103)atC>atT	p.I701I	PCDHA3_ENST00000532566.2_Silent_p.I701I|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACTTGATCGTCGCCATCT	0.662000													13	151					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40702463	40702463	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40702463C>T	ENST00000372771.4	+	8	2116	c.2089C>T	c.(2089-2091)Caa>Taa	p.Q697*		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	697					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AGCTGAACACCAAAATAATGA	0.388000													32	95					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227967505	227967505	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227967505C>T	ENST00000396625.3	-	15	1137	c.930_splice	c.e15+1	p.R310_splice	COL4A4_ENST00000329662.7_Splice_Site_p.R310_splice	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	310	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGATGCTTACCCGAGGCCCTG	0.398000													41	100					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70672748	70672748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70672748G>A	ENST00000322773.4	+	11	1114	c.1012G>A	c.(1012-1014)Gaa>Aaa	p.E338K		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	338	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CAGCAAAGGAGAAACTGGTGA	0.284000													17	42					0	0	1	0	0
INTS3	65123	broad.mit.edu	37	1	153724787	153724787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153724787C>T	ENST00000456435.1	+	8	1330	c.144C>T	c.(142-144)ctC>ctT	p.L48L	INTS3_ENST00000435409.2_Silent_p.L254L|INTS3_ENST00000476843.1_3'UTR|INTS3_ENST00000512605.1_Silent_p.L48L|INTS3_ENST00000318967.2_Silent_p.L254L			Q68E01	INT3_HUMAN	integrator complex subunit 3	255					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTCGGGATCTCGTAAGACTAC	0.428000													89	269					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157931196	157931196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157931196G>A	ENST00000389413.3	-	7	1025	c.922C>T	c.(922-924)Cat>Tat	p.H308Y	PTPRN2_ENST00000389416.4_Missense_Mutation_p.H291Y|PTPRN2_ENST00000404321.2_Missense_Mutation_p.H331Y|PTPRN2_ENST00000389418.4_Missense_Mutation_p.H308Y|PTPRN2_ENST00000409483.1_Missense_Mutation_p.H270Y	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	308						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGGAGGGTATGAATCCGTGCT	0.617000													21	61					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50472794	50472794	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50472794C>A	ENST00000266182.6	-	9	1018	c.1019G>T	c.(1018-1020)cGg>cTg	p.R340L	TTLL8_ENST00000440475.1_Missense_Mutation_p.R324L					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		ACCTCGGCCCCGGGACTTGGC	0.602000													5	41					0.00198382	0.00198545	1	1	0
TLR5	7100	broad.mit.edu	37	1	223285897	223285897	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:223285897G>A	ENST00000540964.1	-	4	938	c.477C>T	c.(475-477)agC>agT	p.S159S	TLR5_ENST00000342210.6_Silent_p.S159S			O60602	TLR5_HUMAN	toll-like receptor 5	159					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		GAAGGTAAAGGCTACGAATCT	0.378000													25	103					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57871033	57871033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57871033C>T	ENST00000393797.2	-	8	1181	c.989G>A	c.(988-990)gGg>gAg	p.G330E	ARHGAP9_ENST00000550454.1_5'UTR|ARHGAP9_ENST00000550288.1_Missense_Mutation_p.G338E|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.G259E|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.G259E|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.G259E|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.G75E			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	259	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			GGTCTGTGTCCCCTCCATGGA	0.542000													8	50					0	0	1	0	0
NKX2-1	7080	broad.mit.edu	37	14	36987098	36987098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:36987098G>A	ENST00000518149.1	-	3	1106	c.501C>T	c.(499-501)ctC>ctT	p.L167L	NKX2-1_ENST00000498187.2_Silent_p.L167L|NKX2-1_ENST00000522719.2_Silent_p.L167L|NKX2-1_ENST00000354822.5_Silent_p.L197L|RP11-896J10.3_ENST00000521945.1_RNA			P43699	NKX21_HUMAN	NK2 homeobox 1	167					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		CCTGCGAGAAGAGCACCCGGC	0.672000			A		NSCLC								7	15					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188460	7188460	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7188460G>A	ENST00000542285.1	-	11	1487	c.1338C>T	c.(1336-1338)ctC>ctT	p.L446L				P00736	C1R_HUMAN	complement component 1, r subcomponent	498	Sushi 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGGCAGCTGTGAGGATCCAGC	0.607000													5	39					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55087397	55087397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55087397G>A	ENST00000251377.3	+	7	1209	c.1076G>A	c.(1075-1077)gGg>gAg	p.G359E	LILRA2_ENST00000251376.3_Missense_Mutation_p.G359E|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391737.1_Missense_Mutation_p.G347E|LILRA2_ENST00000391738.3_Missense_Mutation_p.G359E					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		ACCAAGGAGGGGGCAGGCCAT	0.617000													32	62					0	0	1	0	0
LRCH4	4034	broad.mit.edu	37	7	100176357	100176357	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100176357G>A	ENST00000310300.6	-	5	703	c.651C>T	c.(649-651)tcC>tcT	p.S217S	LRCH4_ENST00000497245.1_5'UTR	NM_002319.3	NP_002310.2	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 4	217					nervous system development	PML body	protein binding			NS(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	23	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGGGATTCGGGAGACGCGGT	0.622000													7	68					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367179	107367179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107367179G>A	ENST00000542196.1	-	1	772	c.730C>T	c.(730-732)Cat>Tat	p.H244Y		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ACAGTCAGATGGGCTGAACAG	0.413000													33	61					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66423280	66423280	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66423280G>A	ENST00000341529.3	+	5	784	c.636G>A	c.(634-636)acG>acA	p.T212T	CDH5_ENST00000563425.2_Silent_p.T212T	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	212	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		TCACAATAACGAAAAGCTTGG	0.567000													26	65					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118957062	118957062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118957062C>T	ENST00000334549.1	+	1	63	c.63C>T	c.(61-63)ttC>ttT	p.F21F		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	21						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		GAAAGCTCTTCCCTGGCCTCT	0.632000													24	48					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659603	24659603	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24659603C>T	ENST00000414583.2	+	0	3128					NR_003714.1																						CGAAGGCTGCCTTCAGTGCCT	0.652000													3	10					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10602081	10602081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10602081C>T	ENST00000547195.1	-	19	2643	c.2143G>A	c.(2143-2145)Gaa>Aaa	p.E715K	MRVI1_ENST00000531107.1_Missense_Mutation_p.E798K|MRVI1-AS1_ENST00000529979.1_RNA|MRVI1_ENST00000552103.1_Missense_Mutation_p.E715K|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000421747.1_Missense_Mutation_p.E797K|MRVI1_ENST00000558540.1_Missense_Mutation_p.E491K|MRVI1_ENST00000527509.2_Missense_Mutation_p.E715K|MRVI1_ENST00000545852.1_Missense_Mutation_p.E491K|MRVI1_ENST00000436272.1_Missense_Mutation_p.E779K|MRVI1-AS1_ENST00000529829.1_RNA|MRVI1_ENST00000541483.1_Missense_Mutation_p.E600K|MRVI1_ENST00000423302.2_Missense_Mutation_p.E806K|MRVI1_ENST00000424001.1_Missense_Mutation_p.E491K|MRVI1_ENST00000534266.2_Missense_Mutation_p.E491K	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	779					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTCTGTTCTTCCTCCTCCTCC	0.493000													72	184					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674013	167674013	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167674013G>A	ENST00000519204.1	+	26	5824	c.5706G>A	c.(5704-5706)ggG>ggA	p.G1902G	TENM2_ENST00000403607.2_Silent_p.G1847G|TENM2_ENST00000545108.1_Silent_p.G2022G|TENM2_ENST00000518659.1_Silent_p.G2023G|TENM2_ENST00000520394.1_Silent_p.G1784G					teneurin transmembrane protein 2																		ACAAGTATGGGAAACTCTCCA	0.507000													35	85					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756783	71756783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71756783G>A	ENST00000318442.5	-	2	1031	c.541C>T	c.(541-543)Cac>Tac	p.H181Y		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		AGGCCCGGGTGGACTTTGGGG	0.662000													46	118					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100675256	100675256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100675256C>T	ENST00000306151.4	+	3	623	c.559C>T	c.(559-561)Cct>Tct	p.P187S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	187	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TATGAGCACACCTCTGACCAC	0.428000													57	277					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140201489	140201489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140201489C>T	ENST00000529859.1	+	1	129	c.129C>T	c.(127-129)ttC>ttT	p.F43F	PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000378126.3_Silent_p.F43F|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Silent_p.F43F	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGGAACCTTCGTTGGCCGCA	0.667000													28	127					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58232411	58232411	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58232411T>A	ENST00000317398.6	-	4	1138	c.1043A>T	c.(1042-1044)aAa>aTa	p.K348I	AC003006.7_ENST00000599221.1_Intron|ZNF671_ENST00000335820.3_Missense_Mutation_p.K250I	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCTAAAGAATTTCCCACATTC	0.448000													9	89					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43318761	43318761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43318761G>A	ENST00000331495.3	+	14	1681	c.1345G>A	c.(1345-1347)Gaa>Aaa	p.E449K	FMNL1_ENST00000587489.1_Missense_Mutation_p.E27K|FMNL1_ENST00000328118.3_Missense_Mutation_p.E449K|CTD-2020K17.3_ENST00000587534.1_RNA	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	449	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						GCGCTTCAGCGAATCGACCGC	0.687000													3	4					0	0	1	0	0
FEZF2	55079	broad.mit.edu	37	3	62358297	62358297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:62358297C>T	ENST00000283268.3	-	2	541	c.247G>A	c.(247-249)Gtg>Atg	p.V83M	FEZF2_ENST00000475839.1_Missense_Mutation_p.V83M|FEZF2_ENST00000486811.1_Missense_Mutation_p.V83M	NM_018008.3	NP_060478.3	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	83					transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|lung(8)|skin(1)	20		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		TTTGACGGCACCTCGTAGCCT	0.706000													18	46					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120817749	120817749	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:120817749G>A	ENST00000369144.3	-	12	1823	c.1696C>T	c.(1696-1698)Cag>Tag	p.Q566*	EIF3A_ENST00000541549.1_Nonsense_Mutation_p.Q532*|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	566					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AGGATCCGCTGGTGCTCTTTT	0.433000													7	20					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55839341	55839341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:55839341G>A	ENST00000302000.6	-	3	234	c.140C>T	c.(139-141)cCt>cTt	p.P47L	PYGO1_ENST00000563719.1_Missense_Mutation_p.P47L	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	47	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		AGGGAAAGAAGGTCCCTGAAA	0.363000													10	60					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233231504	233231504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233231504G>A	ENST00000258229.8	-	22	4177	c.3943C>T	c.(3943-3945)Cct>Tct	p.P1315S		NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1315						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGGATACGAGGAATGGCAAAG	0.448000													6	11					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38941495	38941495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38941495G>A	ENST00000302328.3	-	13	2110	c.1912C>T	c.(1912-1914)Cgc>Tgc	p.R638C	SCN11A_ENST00000456224.3_Missense_Mutation_p.R638C|SCN11A_ENST00000444237.2_Missense_Mutation_p.R638C|SCN11A_ENST00000450244.1_Missense_Mutation_p.R638C	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	638					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CAGCCTCGGCGAAAGTAGTGG	0.423000													14	51					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30134964	30134964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30134964G>A	ENST00000376694.4	+	2	862	c.393G>A	c.(391-393)agG>agA	p.R131R	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	131					mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						ATCGTCTCAGGAGTCGACTGG	0.468000													16	70					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20492183	20492183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20492183G>A	ENST00000573854.1	+	12	1563	c.1449G>A	c.(1447-1449)atG>atA	p.M483I	ACSM2A_ENST00000575690.1_Missense_Mutation_p.M483I|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.M483I|ACSM2A_ENST00000536134.1_Missense_Mutation_p.M255I|ACSM2A_ENST00000417235.2_Missense_Mutation_p.M404I|ACSM2A_ENST00000396104.2_Missense_Mutation_p.M483I	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	483					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						ATGCACTGATGGAGCACCCTG	0.567000													27	53					0	0	1	0	0
HTATIP2	10553	broad.mit.edu	37	11	20404709	20404709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20404709C>T	ENST00000451739.2	+	5	1128	c.687C>T	c.(685-687)gcC>gcT	p.A229A	HTATIP2_ENST00000421577.2_Silent_p.A229A|HTATIP2_ENST00000443524.2_Silent_p.A229A|HTATIP2_ENST00000419348.2_Silent_p.A263A|HTATIP2_ENST00000531058.1_Silent_p.A183A	NM_001098522.1	NP_001091992.1	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa	229					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity			large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						AGAACAAGGCCATCCATGACC	0.493000													7	25					0	0	1	0	0
HOXB4	3214	broad.mit.edu	37	17	46654296	46654296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46654296G>A	ENST00000332503.5	-	2	2335	c.544C>T	c.(544-546)Cac>Tac	p.H182Y	HOXB3_ENST00000498678.1_Intron|HOXB3_ENST00000476342.1_Intron|HOXB3_ENST00000472863.1_Intron|HOXB3_ENST00000552000.2_Intron|HOXB3_ENST00000460160.1_Intron|HOXB3_ENST00000489475.1_Intron|HOXB3_ENST00000465120.3_Intron|HOXB-AS3_ENST00000465846.2_RNA	NM_024015.4	NP_076920.1	P17483	HXB4_HUMAN	homeobox B4	182						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	9						CGGTTGTAGTGAAATTCCTTC	0.632000													60	58					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23020050	23020050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23020050G>A	ENST00000327968.5	+	1	1964	c.1876G>A	c.(1876-1878)Gag>Aag	p.E626K	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	626						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						AAGACGCAAGGAGTTTTATTT	0.363000													15	13					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5247968	5247968	+	Missense_Mutation	SNP	G	G	A	rs33930476		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5247968G>A	ENST00000335295.3	-	2	329	c.154C>T	c.(154-156)Cct>Tct	p.P52S		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	52			P -> R (in Willamette; O(2) affinity up; unstable).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	ACAGCATCAGGAGTGGACAGA	0.537000									Sickle Cell Trait				37	115					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	86996206	86996206	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:86996206G>A	ENST00000398399.2	-	4	1312	c.949C>T	c.(949-951)Caa>Taa	p.Q317*		NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CTCTTGTCTTGATGCTGTAGA	0.378000													10	92					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17507464	17507464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17507464G>A	ENST00000381869.3	-	12	3703	c.3230C>T	c.(3229-3231)cCt>cTt	p.P1077L	MTUS1_ENST00000518713.1_5'UTR|MTUS1_ENST00000544260.1_Missense_Mutation_p.P276L|MTUS1_ENST00000400046.1_Missense_Mutation_p.P203L|MTUS1_ENST00000297488.6_Missense_Mutation_p.P297L|MTUS1_ENST00000381861.3_Missense_Mutation_p.P378L|MTUS1_ENST00000262102.6_Missense_Mutation_p.P1131L|MTUS1_ENST00000519263.1_Missense_Mutation_p.P1077L	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	1131						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		CATGATCTGAGGATTTTTCTG	0.353000													34	84					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675169	81675169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81675169C>T	ENST00000550584.2	-	26	3374	c.3079G>A	c.(3079-3081)Gaa>Aaa	p.E1027K	PPFIA2_ENST00000333447.7_Missense_Mutation_p.E1012K|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Missense_Mutation_p.E1012K|PPFIA2_ENST00000541570.2_Missense_Mutation_p.E563K|PPFIA2_ENST00000541017.1_Missense_Mutation_p.E213K|RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000552948.1_Missense_Mutation_p.E1006K|PPFIA2_ENST00000548586.1_Missense_Mutation_p.E1021K|PPFIA2_ENST00000407050.4_Missense_Mutation_p.E926K|PPFIA2_ENST00000550359.2_Missense_Mutation_p.E874K|PPFIA2_ENST00000443686.3_Missense_Mutation_p.E922K|PPFIA2_ENST00000549396.1_Missense_Mutation_p.E1027K	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	926								p.E1027K(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GGAAGCCATTCATTTCCAATC	0.393000													29	81					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31317955	31317955	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31317955G>A	ENST00000265071.2	+	11	2071	c.1806G>A	c.(1804-1806)gcG>gcA	p.A602A	CDH6_ENST00000514738.1_Silent_p.A547A	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	602	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CCTGCCATGCGGAGGCGCTCA	0.572000													19	48					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19786502	19786502	+	Silent	SNP	C	C	T	rs144667976		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:19786502C>T	ENST00000341998.2	-	1	424	c.363G>A	c.(361-363)ccG>ccA	p.P121P	SLC24A2_ENST00000286344.3_Silent_p.P121P	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	121					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		AGATGTCTTTCGGGTAGTCTC	0.428000													9	92					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646505	57646505	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57646505G>A	ENST00000269834.1	-	5	1585	c.1200C>T	c.(1198-1200)ttC>ttT	p.F400F		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTTCTGAAAGAAGGCTTTTC	0.378000													69	170					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652734	121652734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121652734C>T	ENST00000393386.2	+	12	4045	c.3634C>T	c.(3634-3636)Ccc>Tcc	p.P1212S	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1212					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GGTTGAAACCCCCAAAGTTGA	0.388000													56	172					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18770674	18770674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18770674C>T	ENST00000380548.4	+	17	2631	c.2292C>T	c.(2290-2292)ttC>ttT	p.F764F		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	764						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		ATGGCAGCTTCCTGGAGCTTC	0.527000													6	25					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924844	188924844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:188924844C>T	ENST00000326866.4	+	4	1291	c.883C>T	c.(883-885)Cac>Tac	p.H295Y	ZFP42_ENST00000509524.1_Missense_Mutation_p.H295Y	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	295					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		CCTGAAAGCCCACATCCTAAC	0.463000													10	42					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087344	9087344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9087344G>A	ENST00000397910.4	-	1	4674	c.4471C>T	c.(4471-4473)Cct>Tct	p.P1491S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1491	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGACATAGGTGGAAAAATA	0.428000													18	203					0	0	1	0	0
STMN3	50861	broad.mit.edu	37	20	62275220	62275220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62275220G>A	ENST00000370053.1	-	3	261	c.180C>T	c.(178-180)tcC>tcT	p.S60S	STMN3_ENST00000540534.1_Silent_p.S49S	NM_001276310.1|NM_015894.2	NP_001263239.1|NP_056978.2	Q9NZ72	STMN3_HUMAN	stathmin-like 3	60					cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)	8	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			GGTCAGAAGGGGACTTGAGGA	0.617000													41	100					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74154189	74154189	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74154189G>A	ENST00000443185.2	-	3	1139	c.822C>T	c.(820-822)ttC>ttT	p.F274F	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		AGCCGTGGTCGAAGGAGCCCC	0.647000													14	31					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34506728	34506728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34506728C>T	ENST00000242317.4	+	13	1338	c.1167C>T	c.(1165-1167)ctC>ctT	p.L389L		NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	389					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		TCATGTGTCTCGACATCCACG	0.577000									Kartagener syndrome				27	47					0	0	1	0	0
IGLV2-33	28811	broad.mit.edu	37	22	22930884	22930884	+	RNA	SNP	C	C	T	rs112677281		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22930884C>T	ENST00000390302.2	+	0	137																											GACTCAGCCTCCTTTTGTGTC	0.567000													98	218					0	0	1	0	0
AAAS	8086	broad.mit.edu	37	12	53702957	53702957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53702957G>A	ENST00000209873.4	-	9	1084	c.919C>T	c.(919-921)Cct>Tct	p.P307S	AAAS_ENST00000550286.1_Missense_Mutation_p.P183S|AAAS_ENST00000394384.3_Missense_Mutation_p.P274S	NM_015665.5	NP_056480.1	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency, alacrimia	307					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	20						ACAGCTGAAGGAGTGGTAGCC	0.582000													76	159					0	0	1	0	0
TNRC6C	57690	broad.mit.edu	37	17	76046247	76046247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76046247C>T	ENST00000335749.4	+	3	1673	c.1104C>T	c.(1102-1104)gtC>gtT	p.V368V	TNRC6C_ENST00000541771.1_Silent_p.V368V|TNRC6C_ENST00000588061.1_Silent_p.V368V|TNRC6C_ENST00000588847.1_Silent_p.V368V|TNRC6C_ENST00000544502.1_Silent_p.V368V|TNRC6C_ENST00000301624.4_Silent_p.V368V	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	368	Gly-rich.|Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GTCCTAGTGTCACCAGCCAGA	0.527000													19	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056435	9056435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9056435G>A	ENST00000397910.4	-	3	31214	c.31011C>T	c.(31009-31011)ttC>ttT	p.F10337F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10339	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTGGTAGTGAAGGTTGAAG	0.522000													28	69					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6939120	6939120	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6939120G>A	ENST00000251761.8	+	0	629				LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						AAGTACAGACGAATGTCGGGA	0.592000													15	101					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54673325	54673325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54673325G>A	ENST00000376591.4	-	3	516	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	TMC4_ENST00000301187.4_Missense_Mutation_p.R123W|TMC4_ENST00000476013.2_5'UTR	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	129						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TTGGACCTCCGAAGTAGCCGC	0.592000													42	82					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45798932	45798932	+	Missense_Mutation	SNP	C	C	T	rs138507862		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45798932C>T	ENST00000397928.1	+	8	1512	c.1067C>T	c.(1066-1068)tCg>tTg	p.S356L	TRPM2_ENST00000397932.2_Missense_Mutation_p.S356L|TRPM2_ENST00000300482.5_Missense_Mutation_p.S356L|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.S356L	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	356						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GTGGAGGGCTCGGGCCGCGTG	0.642000													40	77					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10401081	10401081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10401081G>A	ENST00000226207.5	-	31	4429	c.4335C>T	c.(4333-4335)gcC>gcT	p.A1445A	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1445			A -> T (in a breast cancer sample; somatic mutation).			muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTTTGTCCAGGGCGGCACAGG	0.453000													41	62					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74548880	74548880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:74548880G>A	ENST00000263665.6	-	2	139	c.112C>T	c.(112-114)Cct>Tct	p.P38S		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	38	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GAACCAACAGGGAAAATGCTG	0.363000													11	125					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18257552	18257552	+	Silent	SNP	G	G	A	rs138099497		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18257552G>A	ENST00000286479.3	+	2	146	c.39G>A	c.(37-39)aaG>aaA	p.K13K	NAT2_ENST00000520116.1_Intron	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	13					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		TTGGCTATAAGAACTCTAGGA	0.373000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				56	167					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221429	161221429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161221429G>A	ENST00000327928.4	+	4	1133	c.1133G>A	c.(1132-1134)gGg>gAg	p.G378E		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	378	C1q.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						CCTGTCACTGGGAAGTTTAAC	0.448000													11	29					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40689277	40689277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40689277C>T	ENST00000298910.7	+	23	2985	c.2927C>T	c.(2926-2928)tCt>tTt	p.S976F	LRRK2_ENST00000343742.2_Missense_Mutation_p.S976F	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	976					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGCATTTCTTCTCTGGCTTCT	0.338000													17	61					0	0	1	0	0
C19orf33	64073	broad.mit.edu	37	19	38795318	38795318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38795318G>A	ENST00000591889.1	+	5	455	c.455G>A	c.(454-456)gGa>gAa	p.G152E	C19orf33_ENST00000588605.1_Silent_p.R84R|C19orf33_ENST00000301246.5_Missense_Mutation_p.D65N																							TTCGGACACGGATGTGAAGGT	0.692000													17	32					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86493638	86493638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86493638G>A	ENST00000394720.2	+	5	1711	c.1534G>A	c.(1534-1536)Gga>Aga	p.G512R	GRM3_ENST00000546348.1_Silent_p.R461R|GRM3_ENST00000536043.1_Silent_p.R741R|GRM3_ENST00000361669.2_Silent_p.R869R|GRM3_ENST00000439827.1_Missense_Mutation_p.G514R			Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	0				P -> A (in Ref. 3; AAH22496).	synaptic transmission	integral to plasma membrane		p.R869R(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCAATGGGCGGGAAGTCCTCG	0.473000													39	136					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135779312	135779312	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:135779312G>A	ENST00000375845.3	-	2	141	c.111C>T	c.(109-111)atC>atT	p.I37I	MAP3K19_ENST00000392917.3_Silent_p.I37I|MAP3K19_ENST00000392918.3_Silent_p.I37I|MAP3K19_ENST00000392915.1_Silent_p.I54I|MAP3K19_ENST00000375844.3_Silent_p.I37I|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000358371.4_Silent_p.I37I	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		TTTGCAAGATGATGTTTTGAT	0.373000													18	35					0	0	1	0	0
BIRC3	330	broad.mit.edu	37	11	102201741	102201741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102201741G>A	ENST00000263464.3	+	6	3843	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K	BIRC3_ENST00000532808.1_Missense_Mutation_p.E365K	NM_001165.4	NP_001156.1	Q13489	BIRC3_HUMAN	baculoviral IAP repeat containing 3	365					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|ovary(3)|skin(1)	21	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TATCCATTTTGAACCTGGAGA	0.328000			T	MALT1	MALT								26	55					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150349343	150349343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150349343G>A	ENST00000218316.3	+	2	1357	c.1288G>A	c.(1288-1290)Ggt>Agt	p.G430S		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	430	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					GCCTGCCTCTGGTCACCCCAA	0.547000													145	100					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152708338	152708338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152708338G>A	ENST00000367255.5	-	54	8957	c.8356C>T	c.(8356-8358)Cac>Tac	p.H2786Y	SYNE1_ENST00000341594.5_Missense_Mutation_p.H2825Y|SYNE1_ENST00000423061.1_Missense_Mutation_p.H2793Y|SYNE1_ENST00000448038.1_Missense_Mutation_p.H2793Y|SYNE1_ENST00000265368.4_Missense_Mutation_p.H2786Y	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2786					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTCTCGTGTGATCTTCTGCC	0.493000										HNSCC(10;0.0054)			47	76					0	0	1	0	0
MESP1	55897	broad.mit.edu	37	15	90293986	90293986	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90293986G>A	ENST00000300057.4	-	1	555	c.477C>T	c.(475-477)tcC>tcT	p.S159S	MESP1_ENST00000559894.1_Intron	NM_018670.3	NP_061140.1	Q9BRJ9	MESP1_HUMAN	mesoderm posterior 1 homolog (mouse)	159					cardiac atrium formation|cardiac cell fate determination|cardiac vascular smooth muscle cell differentiation|cardiac ventricle formation|cardioblast anterior-lateral migration|cardioblast migration to the midline involved in heart field formation|endothelial cell differentiation|gastrulation|growth involved in heart morphogenesis|heart looping|lateral mesoderm development|negative regulation of endodermal cell fate specification|negative regulation of mesodermal cell fate specification|negative regulation of transcription, DNA-dependent|neurogenesis|Notch signaling pathway|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|positive regulation of hepatocyte differentiation|positive regulation of Notch signaling pathway|positive regulation of striated muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|secondary heart field specification|sinoatrial node cell differentiation|sinus venosus morphogenesis		sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|kidney(1)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			AGCCCCGAGGGGACCCCGCGT	0.736000													4	12					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25376587	25376587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25376587G>A	ENST00000255324.5	+	14	1879	c.1827G>A	c.(1825-1827)atG>atA	p.M609I	RNF17_ENST00000381921.1_Missense_Mutation_p.M609I|RNF17_ENST00000255325.5_Missense_Mutation_p.M610I	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	609					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTGTTTCAATGAAAGTTTTTA	0.363000													37	84					0	0	1	0	0
HBD	3045	broad.mit.edu	37	11	5254020	5254020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5254020C>T	ENST00000292901.3	-	3	373	c.324G>A	c.(322-324)aaG>aaA	p.K108K				P02042	HBD_HUMAN	hemoglobin, delta	108					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGAACCTTCTTACACACCT	0.393000													13	17					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42529856	42529856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:42529856G>A	ENST00000282030.5	+	4	847	c.551G>A	c.(550-552)aGg>aAg	p.R184K		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	184						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCTTACGAGAGGCCCCAGAAA	0.483000									Schinzel-Giedion syndrome				16	38					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065578	55065578	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55065578C>T	ENST00000526016.1	-	0	130					NR_038174.2																						ATGTTGTCTCCTTGCATTTAG	0.493000													12	29					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633707	116633707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:116633707G>A	ENST00000260210.4	-	4	621	c.598C>T	c.(598-600)Cct>Tct	p.P200S	BUD13_ENST00000375445.3_Missense_Mutation_p.P200S	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	200	Arg-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGGGGAGAAGGATCTGGAGAA	0.567000													45	127					0	0	1	0	0
GPC1	2817	broad.mit.edu	37	2	241401948	241401948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241401948C>T	ENST00000264039.2	+	3	914	c.666C>T	c.(664-666)tcC>tcT	p.S222S		NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	222					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		CTGCTCGCTCCTTTGTGCAGG	0.711000													14	36					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41333221	41333221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41333221C>T	ENST00000551295.2	+	12	1430	c.1313C>T	c.(1312-1314)cCt>cTt	p.P438L	CNTN1_ENST00000360099.3_Missense_Mutation_p.P438L|CNTN1_ENST00000547702.1_Missense_Mutation_p.P438L|CNTN1_ENST00000347616.1_Missense_Mutation_p.P438L|CNTN1_ENST00000348761.2_Missense_Mutation_p.P427L|CNTN1_ENST00000547849.1_Missense_Mutation_p.P438L	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	438	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GAATGCAAACCTAAAGCTGCA	0.398000													24	41					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31533831	31533831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31533831C>T	ENST00000215885.3	-	4	1183	c.931G>A	c.(931-933)Ggg>Agg	p.G311R		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	311					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						TGTGGTGGCCCCTTCCGAAGG	0.647000													59	138					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18524140	18524140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18524140C>T	ENST00000433979.1	+	12	1768	c.1652C>T	c.(1651-1653)tCa>tTa	p.S551L	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.S551L|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.S592L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	551					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GAAATAAAGTCACTTCCAAGG	0.368000													8	18					0	0	1	0	0
CD80	941	broad.mit.edu	37	3	119263605	119263605	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119263605C>T	ENST00000264246.3	-	3	572	c.210G>A	c.(208-210)aaG>aaA	p.K70K	CD80_ENST00000383669.3_Silent_p.K70K|CD80_ENST00000478182.1_Silent_p.K70K|CD80_ENST00000383668.3_Silent_p.K70K	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	70	Ig-like V-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding	p.K70N(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	GCACCATTTTCTTCTCCTTTT	0.458000													24	86					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75408412	75408412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75408412G>A	ENST00000394810.2	-	4	1147	c.998C>T	c.(997-999)tCc>tTc	p.S333F	SYNPO2L_ENST00000372873.4_Missense_Mutation_p.S109F|SYNPO2L_ENST00000372872.4_Missense_Mutation_p.S333F	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	333						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					GTCCAGCTCGGACTCACTCGT	0.627000													16	63					0	0	1	0	0
CBLN3	643866	broad.mit.edu	37	14	24898065	24898065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24898065C>T	ENST00000267406.6	-	1	666	c.196G>A	c.(196-198)Gag>Aag	p.E66K	CBLN3_ENST00000555436.1_Intron	NM_001039771.2	NP_001034860.1	Q6UW01	CBLN3_HUMAN	cerebellin 3 precursor	66						cell junction|extracellular region|synapse				central_nervous_system(1)|lung(3)	4				GBM - Glioblastoma multiforme(265;0.00159)		GGGGGTGCCTCTCCCAGGGCT	0.692000													3	14					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55419267	55419267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55419267G>A	ENST00000312422.2	+	1	888	c.888G>A	c.(886-888)atG>atA	p.M296I		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				AGAATGCAATGAAGAAACTGT	0.358000													78	214					0	0	1	0	0
OR6B2	389090	broad.mit.edu	37	2	240969787	240969787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:240969787G>A	ENST00000402971.2	-	1	119	c.60C>T	c.(58-60)gcC>gcT	p.A20A		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GCAGCCCTGGGGCCGTGGGGA	0.582000													6	58					0	0	1	0	0
CNTLN	54875	broad.mit.edu	37	9	17332635	17332635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:17332635C>T	ENST00000380647.3	+	10	1635	c.1551C>T	c.(1549-1551)tcC>tcT	p.S517S	CNTLN_ENST00000262360.5_Silent_p.S517S|CNTLN_ENST00000425824.1_Silent_p.S517S			Q9NXG0	CNTLN_HUMAN	centlein, centrosomal protein	517						centriole|membrane	two-component sensor activity			breast(6)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53				GBM - Glioblastoma multiforme(50;6.14e-10)		GGTCTTTGTCCCCAAAGAGCT	0.398000													31	58					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47337533	47337533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47337533C>T	ENST00000400314.1	+	11	1045	c.707C>T	c.(706-708)cCt>cTt	p.P236L	PCBP3_ENST00000400308.1_Missense_Mutation_p.P211L|PCBP3_ENST00000468429.1_3'UTR|PCBP3_ENST00000449640.1_Missense_Mutation_p.P236L|PCBP3_ENST00000400310.1_Missense_Mutation_p.P236L|PCBP3_ENST00000400304.1_Missense_Mutation_p.P227L|PCBP3_ENST00000400309.1_Missense_Mutation_p.P236L			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	236					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TATGCCATCCCTCACCCGGAT	0.527000													36	77					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3658803	3658803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:3658803G>A	ENST00000404826.2	+	2	529	c.390G>A	c.(388-390)ggG>ggA	p.G130G	SDK1_ENST00000389531.3_Silent_p.G130G	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	130	Ig-like C2-type 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTGCCGAAGGGAGCTGGCCTT	0.478000													9	54					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46787381	46787381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46787381G>A	ENST00000230588.4	+	7	505	c.496G>A	c.(496-498)Gag>Aag	p.E166K		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	166	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			ATTTTACCACGAGCAGTCAAG	0.478000													72	150					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95053750	95053750	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95053750C>T	ENST00000329597.7	+	3	261	c.51C>T	c.(49-51)gcC>gcT	p.A17A	SERPINA5_ENST00000554866.1_Silent_p.A17A|SERPINA5_ENST00000553780.1_Silent_p.A17A|SERPINA5_ENST00000554276.1_Silent_p.A17A	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	17					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CTCAGGGGGCCTCCCTTCACC	0.592000													39	92					0	0	1	0	0
SLC22A4	6583	broad.mit.edu	37	5	131670542	131670542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131670542G>A	ENST00000200652.3	+	7	1352	c.1178G>A	c.(1177-1179)cGa>cAa	p.R393Q	AC034220.3_ENST00000437091.1_RNA|AC034220.3_ENST00000417795.1_RNA	NM_003059.2	NP_003050.2	Q9H015	S22A4_HUMAN	solute carrier family 22 (organic cation/zwitterion transporter), member 4	393					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CTGCTATTGCGAACCCTGCCC	0.473000													60	223					0	0	1	0	0
BDKRB2	624	broad.mit.edu	37	14	96707226	96707226	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96707226C>T	ENST00000542454.2	+	3	3568	c.480C>T	c.(478-480)ctC>ctT	p.L160L	BDKRB2_ENST00000306005.3_Silent_p.L187L|RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000539359.1_Silent_p.L160L|BDKRB2_ENST00000554311.1_Silent_p.L187L			P30411	BKRB2_HUMAN	bradykinin receptor B2	187					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		GTACGCTGCTCCTGAGCTCAC	0.612000													21	72					0	0	1	0	0
CDCA8	55143	broad.mit.edu	37	1	38173996	38173996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38173996C>T	ENST00000373055.1	+	10	1074	c.801C>T	c.(799-801)aaC>aaT	p.N267N	CDCA8_ENST00000327331.2_Silent_p.N267N	NM_001256875.1|NM_018101.3	NP_001243804.1|NP_060571.1	Q53HL2	BOREA_HUMAN	cell division cycle associated 8	267					cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(1)|stomach(1)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTTTTTAGAACCGTCTCGCCC	0.507000													24	59					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184039162	184039162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184039162C>T	ENST00000342981.4	+	9	1204	c.790C>T	c.(790-792)Ccg>Tcg	p.P264S	EIF4G1_ENST00000441154.1_Missense_Mutation_p.P100S|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000319274.6_Missense_Mutation_p.P264S|EIF4G1_ENST00000427845.1_Missense_Mutation_p.P177S|EIF4G1_ENST00000350481.5_Missense_Mutation_p.P100S|EIF4G1_ENST00000424196.1_Missense_Mutation_p.P271S|EIF4G1_ENST00000352767.3_Missense_Mutation_p.P271S|EIF4G1_ENST00000414031.1_Missense_Mutation_p.P224S|EIF4G1_ENST00000434061.2_Missense_Mutation_p.P68S|EIF4G1_ENST00000411531.1_Missense_Mutation_p.P224S|EIF4G1_ENST00000392537.2_Missense_Mutation_p.P177S|EIF4G1_ENST00000435046.2_Missense_Mutation_p.P68S|EIF4G1_ENST00000382330.3_Missense_Mutation_p.P271S|EIF4G1_ENST00000346169.2_Missense_Mutation_p.P264S	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	264					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GTCGCCTTCTCCGACCCCATC	0.567000													29	86					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65627693	65627693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65627693G>A	ENST00000327987.4	-	4	872	c.621C>T	c.(619-621)ttC>ttT	p.F207F		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	207	Ig-like C2-type 2.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCACACAGTGGAAGATGCCAC	0.597000													64	67					0	0	1	0	0
GPR78	27201	broad.mit.edu	37	4	8583216	8583216	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8583216C>T	ENST00000382487.4	+	1	924	c.507C>T	c.(505-507)ttC>ttT	p.F169F	GPR78_ENST00000509216.1_Intron	NM_080819.4	NP_543009.2	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	169					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|kidney(4)|large_intestine(1)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	26						GTCCGCGCTTCGCAGCCTTCA	0.697000													4	8					0	0	1	0	0
ZNF197	10168	broad.mit.edu	37	3	44684449	44684449	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44684449C>T	ENST00000396058.1	+	5	1994	c.1827C>T	c.(1825-1827)ttC>ttT	p.F609F	ZNF197_ENST00000383744.4_Intron|ZNF197_ENST00000344387.4_Silent_p.F609F|ZNF197_ENST00000383745.2_Intron|RP11-944L7.4_ENST00000457331.1_RNA			O14709	ZN197_HUMAN	zinc finger protein 197	609					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		AGTCAAACTTCATTGACCATA	0.408000													30	53					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26885831	26885831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:26885831C>T	ENST00000231021.4	-	11	1946	c.1774G>A	c.(1774-1776)Gat>Aat	p.D592N		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	592	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.D592N(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CCTTGATTATCGCAGGCACAC	0.478000													9	19					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908361	164908361	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164908361C>A	ENST00000475390.1	-	2	701	c.258G>T	c.(256-258)agG>agT	p.R86S	SLITRK3_ENST00000241274.3_Missense_Mutation_p.R86S			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	86						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TCATAGAATTCCTCTGCAGAT	0.348000										HNSCC(40;0.11)			33	68					4.02929e-09	4.04455e-09	1	1	0
DNA2	1763	broad.mit.edu	37	10	70218880	70218880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70218880G>A	ENST00000399180.2	-	5	957	c.958C>T	c.(958-960)Cct>Tct	p.P320S	DNA2_ENST00000358410.3_Missense_Mutation_p.P234S|DNA2_ENST00000399179.2_Missense_Mutation_p.P234S			P51530	DNA2L_HUMAN	DNA replication helicase/nuclease 2	234					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						TGCATCTGAGGGAAGTCAGTC	0.348000													3	9					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125805533	125805533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:125805533C>T	ENST00000346248.5	-	2	838	c.196G>A	c.(196-198)Gaa>Aaa	p.E66K	CHST15_ENST00000435907.1_Missense_Mutation_p.E66K|CHST15_ENST00000421115.1_Missense_Mutation_p.E66K|CHST15_ENST00000462406.1_5'UTR	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	66					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						CCCCAGTTTTCGTTCCCTTCA	0.463000													9	81					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985517	108985517	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108985517C>T	ENST00000392806.3	-	2	811	c.643G>A	c.(643-645)Ggg>Agg	p.G215R		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	215						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						TCCTGGTCCCCCTCCTGGCTG	0.687000													25	63					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75022211	75022211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75022211G>A	ENST00000261978.4	-	4	1402	c.1016C>T	c.(1015-1017)cCc>cTc	p.P339L	LTBP2_ENST00000556690.1_Missense_Mutation_p.P339L|CTD-2207P18.1_ENST00000554552.1_lincRNA|LTBP2_ENST00000557425.1_Intron	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	339					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTTACCCCAGGGGGATGAGGG	0.622000													21	128					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64633642	64633642	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64633642C>T	ENST00000498707.1	-	11	2026	c.1684G>A	c.(1684-1686)Gat>Aat	p.D562N	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.D534N	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	562	Disintegrin.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TCCGTCCCATCGGCCCAGGGT	0.522000													30	117					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29040886	29040886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29040886G>A	ENST00000257189.4	+	7	858	c.775G>A	c.(775-777)Gat>Aat	p.D259N		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	259	Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TAAAGTGAAAGATGTCAACGA	0.353000													20	40					0	0	1	0	0
GP9	2815	broad.mit.edu	37	3	128780787	128780787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:128780787G>A	ENST00000307395.4	+	3	427	c.205G>A	c.(205-207)Gga>Aga	p.G69R		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	69					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	CGTGCCCCCGGGAGCCTTTGA	0.682000													16	40					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22846811	22846811	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22846811C>T	ENST00000456783.2	+	4	584	c.340C>T	c.(340-342)Caa>Taa	p.Q114*		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				CAAAATATTTCAATGTGACAA	0.313000													8	20					0	0	1	0	0
PHYH	5264	broad.mit.edu	37	10	13325819	13325819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:13325819G>A	ENST00000396920.3	-	7	1052	c.648C>T	c.(646-648)ttC>ttT	p.F216F	PHYH_ENST00000396913.2_Silent_p.F133F|PHYH_ENST00000263038.4_Silent_p.F233F			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	233					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	GGATCCCGTGGAACATTTTGT	0.478000													39	427					0	0	1	0	0
CCK	885	broad.mit.edu	37	3	42299704	42299704	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42299704G>A	ENST00000396169.2	-	5	1139	c.234C>T	c.(232-234)tcC>tcT	p.S78S	CCK_ENST00000334681.5_Silent_p.S78S|CCK_ENST00000434608.1_Silent_p.S78S	NM_000729.4	NP_000720.1	P06307	CCKN_HUMAN	cholecystokinin	78					axonogenesis|eating behavior|neuron migration		neuropeptide hormone activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6		Ovarian(412;0.0728)		KIRC - Kidney renal clear cell carcinoma(284;0.219)		TCTTAACGATGGACATTCGTC	0.517000													26	60					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21205029	21205029	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21205029G>A	ENST00000381541.3	+	10	1396		c.e10-1		LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Splice_Site|SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000554957.1_Splice_Site																							TATATTTTCAGAAATAGTCCA	0.388000													15	48					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201507489	201507489	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:201507489G>A	ENST00000374700.2	+	25	3053	c.2812G>A	c.(2812-2814)Gaa>Aaa	p.E938K	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	938					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TTGTATCACGGAAGTTGCAGC	0.512000													7	98					0	0	1	0	0
CCR8	1237	broad.mit.edu	37	3	39374734	39374734	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39374734G>A	ENST00000326306.4	+	2	1050	c.912G>A	c.(910-912)ggG>ggA	p.G304G	CCR8_ENST00000414803.1_3'UTR|CCR8_ENST00000545843.1_Silent_p.G221G	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	304					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CTTTTGTTGGGGAGAAGTTCA	0.418000													38	83					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209797190	209797190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209797190G>A	ENST00000391911.1	-	14	2521	c.2132C>T	c.(2131-2133)cCt>cTt	p.P711L	LAMB3_ENST00000356082.4_Missense_Mutation_p.P711L|LAMB3_ENST00000367030.3_Missense_Mutation_p.P711L	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	711	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CTCACCTGAAGGATCAGCACT	0.557000													38	73					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	352969	352969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:352969G>A	ENST00000343164.4	-	3	265	c.213C>T	c.(211-213)ttC>ttT	p.F71F	SLC6A13_ENST00000445055.2_Intron	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	71					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GGTAGGGGATGAAGAAGGCAC	0.527000													23	45					0	0	1	0	0
SCN4B	6330	broad.mit.edu	37	11	118015828	118015828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118015828C>T	ENST00000324727.4	-	2	324	c.178G>A	c.(178-180)Ggc>Agc	p.G60S	SCN4B_ENST00000529878.1_Intron	NM_001142349.1|NM_174934.3	NP_001135821.1|NP_777594.1	Q8IWT1	SCN4B_HUMAN	sodium channel, voltage-gated, type IV, beta subunit	60	Ig-like C2-type.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.33e-05)|Epithelial(105;0.00126)		TCCTCGAAGCCAAAGCAGCTG	0.562000											OREG0021380	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	164					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122551490	122551490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:122551490G>A	ENST00000264357.5	+	11	2030	c.1738G>A	c.(1738-1740)Gaa>Aaa	p.E580K	GRIA3_ENST00000542149.1_Missense_Mutation_p.E580K|GRIA3_ENST00000541091.1_Missense_Mutation_p.E564K|GRIA3_ENST00000371256.5_Missense_Mutation_p.E580K|GRIA3_ENST00000371251.1_Missense_Mutation_p.E580K	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	580					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CAGTCCTTATGAATGGCACTT	0.418000													41	149					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208390835	208390835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:208390835G>A	ENST00000367033.3	-	2	1190	c.433C>T	c.(433-435)Ctc>Ttc	p.L145F		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	145	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		AGGATGAAGAGGTCATCCAGC	0.572000													27	148					0	0	1	0	0
XAF1	54739	broad.mit.edu	37	17	6663021	6663021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6663021C>T	ENST00000361842.3	+	3	448	c.209C>T	c.(208-210)tCg>tTg	p.S70L	XAF1_ENST00000438512.1_Missense_Mutation_p.S70L|XAF1_ENST00000441631.1_Intron|XAF1_ENST00000346752.4_Intron	NM_017523.3	NP_059993.2	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1	70					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding			large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	6						CAGAAGTCCTCGCTGGAGTTT	0.517000													17	62					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233296076	233296076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233296076G>A	ENST00000258229.8	-	19	3704	c.3470C>T	c.(3469-3471)tCa>tTa	p.S1157L	PCNXL2_ENST00000488780.2_Missense_Mutation_p.S290L|PCNXL2_ENST00000520463.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1157						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AATGGGGTGTGAAATCCACAT	0.443000													23	47					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52211401	52211401	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52211401C>T	ENST00000282588.6	+	15	2423	c.1965C>T	c.(1963-1965)ggC>ggT	p.G655G		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	655					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				CTATTGGGGGCCTTGGTGGTG	0.468000													62	114					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19746500	19746500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19746500G>A	ENST00000203556.4	-	14	1495	c.1358C>T	c.(1357-1359)tCg>tTg	p.S453L	GMIP_ENST00000445806.2_Intron|GMIP_ENST00000587238.1_Intron	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	453					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GCCTGTGGACGAAGCCTTCAC	0.597000													33	159					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21236046	21236046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21236046G>A	ENST00000233242.1	-	25	4329	c.4202C>T	c.(4201-4203)tCc>tTc	p.S1401F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1401					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CACATTGTAGGAAAGCAGGTC	0.547000													51	107					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113920	94113920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94113920G>A	ENST00000243673.2	-	4	838	c.667C>T	c.(667-669)Ctc>Ttc	p.L223F	GPR83_ENST00000539203.2_Missense_Mutation_p.L181F	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	223						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GGCAGGCAGAGGGAGCGCACA	0.557000													13	40					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17488851	17488851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17488851C>T	ENST00000400588.1	-	1	261	c.154G>A	c.(154-156)Gag>Aag	p.E52K	GAB4_ENST00000523144.1_5'UTR	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	52	PH.									breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AGCTTCTTCTCGGGGGGCGAC	0.687000													6	14					0	0	1	0	0
SRPK1	6732	broad.mit.edu	37	6	35837432	35837432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35837432G>A	ENST00000373825.2	-	11	1523	c.1238C>T	c.(1237-1239)tCt>tTt	p.S413F	SRPK1_ENST00000373822.1_Missense_Mutation_p.S306F|SRPK1_ENST00000423325.2_Missense_Mutation_p.S397F			Q96SB4	SRPK1_HUMAN	SRSF protein kinase 1	413	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.S413Y(1)		endometrium(2)|large_intestine(10)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21						AGGTGTACAAGAGTCTGTTTC	0.418000													15	44					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47422305	47422305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47422305C>T	ENST00000361866.3	+	32	2354	c.2240C>T	c.(2239-2241)cCc>cTc	p.P747L	COL6A1_ENST00000498614.1_3'UTR	NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	747	C-terminal globular domain.|VWFA 2.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CTCTGCAGCCCCGGCATCCAG	0.701000													4	6					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101765820	101765820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101765820G>A	ENST00000375001.3	+	8	1574	c.1151G>A	c.(1150-1152)gGa>gAa	p.G384E		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	384	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CCCACCGGGGGACCAACCCTC	0.597000													37	54					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875780	247875780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247875780G>A	ENST00000302084.2	-	1	325	c.278C>T	c.(277-279)tCa>tTa	p.S93L	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GCTTGTAAATGATATGGTCTG	0.483000													18	86					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15795653	15795653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15795653G>A	ENST00000550308.1	+	8	1326	c.946G>A	c.(946-948)Gag>Aag	p.E316K	CYP4F12_ENST00000324632.9_Missense_Mutation_p.E316K	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ATTGTCAGATGAGGATATAAG	0.493000													18	80					0	0	1	0	0
VN1R2	317701	broad.mit.edu	37	19	53762792	53762792	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53762792C>T	ENST00000341702.3	+	1	1248	c.1164C>T	c.(1162-1164)ttC>ttT	p.F388F	VN1R2_ENST00000598458.1_Intron	NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	388					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		ATAGACGATTCTTTCATGATT	0.438000													38	100					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97485261	97485261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:97485261G>A	ENST00000376705.2	+	2	1249	c.1225G>A	c.(1225-1227)Gag>Aag	p.E409K		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	409						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					GCAGCTTTACGAGTATGCAAA	0.572000													38	98					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187670	140187670	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140187670G>A	ENST00000530339.1	+	1	898	c.898G>A	c.(898-900)Gga>Aga	p.G300R	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.G300R|PCDHA4_ENST00000512229.2_Missense_Mutation_p.G300R|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1												p.G300*(2)		breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAATTACTGGACAAATTAT	0.358000													26	124					0	0	1	0	0
TRAV3	28690	broad.mit.edu	37	14	22192542	22192542	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22192542C>T	ENST00000390425.2	+	0	493																											AGCGACTCCGCTTTGTACTTC	0.478000													17	27					0	0	1	0	0
ABCF3	55324	broad.mit.edu	37	3	183907661	183907661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183907661C>T	ENST00000429586.2	+	14	1518	c.1333C>T	c.(1333-1335)Cgc>Tgc	p.R445C	EIF2B5_ENST00000444495.1_Intron|ABCF3_ENST00000292808.5_Missense_Mutation_p.R439C	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	445							ATP binding|ATPase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGACCGGTTTCGCTACAATGC	0.557000													12	61					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39008129	39008129	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39008129C>T	ENST00000355481.4	+	66	9947	c.9816C>T	c.(9814-9816)atC>atT	p.I3272I	RYR1_ENST00000360985.3_Silent_p.I3272I|RYR1_ENST00000359596.3_Silent_p.I3272I	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3272					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCATCGAGATCACGCTGCCCA	0.697000													23	33					0	0	1	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187692815	187692815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:187692815C>T	ENST00000295131.2	-	9	1837	c.1798G>A	c.(1798-1800)Gaa>Aaa	p.E600K		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	600					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CGTGTAATTTCCCCCATACAG	0.343000													22	46					0	0	1	0	0
PNLDC1	154197	broad.mit.edu	37	6	160239672	160239672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160239672G>A	ENST00000275275.5	+	16	1381	c.1210G>A	c.(1210-1212)Ggg>Agg	p.G404R	PNLDC1_ENST00000392167.3_Missense_Mutation_p.G415R	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1	404						integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CATCCGAGCGGGGGTCCCAAA	0.572000													6	36					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772291	4772291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:4772291C>T	ENST00000378191.4	+	2	742	c.361C>T	c.(361-363)Cca>Tca	p.P121S	AJAP1_ENST00000378190.3_Missense_Mutation_p.P121S	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	121					cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GGCCAAGCCCCCAGCTGCTGC	0.726000													5	9					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7110510	7110510	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7110510C>T	ENST00000306904.5	+	1	346	c.159C>T	c.(157-159)ttC>ttT	p.F53F		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	53	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTTCGCGTTCGTCACCTTTG	0.592000													6	19					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15262451	15262451	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15262451C>T	ENST00000256953.2	-	5	529	c.192_splice	c.e5-1	p.E65_splice	RERG_ENST00000546331.1_Splice_Site_p.E46_splice|RERG_ENST00000538313.1_Splice_Site_p.E65_splice|RERG_ENST00000536465.1_Splice_Site_p.E65_splice	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	65					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						ATGGTATCTTCCTGTTGGCAA	0.443000													78	299					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45292968	45292968	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:45292968G>A	ENST00000447098.2	-	16	2396	c.2385C>T	c.(2383-2385)gcC>gcT	p.A795A	PTCH2_ENST00000372192.3_Silent_p.A795A	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	795					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					CCTGGTCAAAGGCAGCCTGGA	0.637000									Basal Cell Nevus syndrome				14	88					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152468714	152468714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152468714G>A	ENST00000427231.2	-	78	11993	c.11791C>T	c.(11791-11793)Ctg>Ttg	p.L3931L	NEB_ENST00000409198.1_Silent_p.L3688L|NEB_ENST00000397345.3_Silent_p.L3931L|NEB_ENST00000604864.1_Silent_p.L3931L|NEB_ENST00000172853.10_Silent_p.L3688L|NEB_ENST00000603639.1_Silent_p.L3931L	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3931					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCATTGTCAGGGCATTATTC	0.458000													11	53					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50546582	50546582	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50546582G>A	ENST00000262794.5	+	4	543	c.460G>A	c.(460-462)Gga>Aga	p.G154R	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000540615.1_Missense_Mutation_p.G134R|MOV10L1_ENST00000395858.3_Missense_Mutation_p.G154R|MOV10L1_ENST00000475190.1_3'UTR|MOV10L1_ENST00000545383.1_Missense_Mutation_p.G154R	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	154					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding	p.G154R(1)		breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GCCCTGCAAGGGAGACTGGGT	0.532000													11	28					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76454647	76454647	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76454647C>T	ENST00000389840.5	-	62	10059	c.9935_splice	c.e62+1	p.R3312_splice	DNAH17_ENST00000585328.1_Splice_Site_p.R3321_splice|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GAGCTGATACCTGTTCGCCAG	0.562000													41	76					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68597661	68597661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68597661C>T	ENST00000570495.1	+	5	1263	c.971C>T	c.(970-972)tCc>tTc	p.S324F	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.S324F|ZFP90_ENST00000563169.2_Missense_Mutation_p.S324F			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	324					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CGCAGCTCCTCCCTTGTTCAA	0.502000													23	52					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39606906	39606906	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39606906G>A	ENST00000265708.4	-	18	2042	c.1939C>T	c.(1939-1941)Caa>Taa	p.Q647*	ADAM2_ENST00000347580.4_Nonsense_Mutation_p.Q628*|ADAM2_ENST00000521880.1_Nonsense_Mutation_p.Q584*|ADAM2_ENST00000379853.2_Nonsense_Mutation_p.Q491*	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	647					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		AGATCTGATTGAACTGAGCAA	0.383000													36	120					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42048690	42048690	+	Silent	SNP	G	G	A	rs35586296		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42048690G>A	ENST00000372584.1	-	3	2793	c.1779C>T	c.(1777-1779)atC>atT	p.I593I	HIVEP3_ENST00000247584.5_Silent_p.I593I|HIVEP3_ENST00000372583.1_Silent_p.I593I|HIVEP3_ENST00000429157.2_Silent_p.I593I	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	593	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AAGGTAATTCGATTGCCGGCT	0.582000													29	88					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13029625	13029625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:13029625C>T	ENST00000399002.2	+	2	424	c.150C>T	c.(148-150)ctC>ctT	p.L50L	SPTLC3_ENST00000476791.1_3'UTR|SPTLC3_ENST00000378194.4_Silent_p.L50L	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	50					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	ATGATAAGCTCATTGTTGAAT	0.358000													62	182					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129137225	129137225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129137225G>A	ENST00000505956.1	-	3	715	c.553C>T	c.(553-555)Cct>Tct	p.P185S	EFCAB12_ENST00000326085.3_Missense_Mutation_p.P185S	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		GACAGGGCAGGGGGCTCGGGC	0.602000													11	30					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62542622	62542622	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:62542622C>T	ENST00000512091.1	+	5	1095	c.348C>T	c.(346-348)taC>taT	p.Y116Y	LPHN3_ENST00000507164.1_Silent_p.Y184Y|LPHN3_ENST00000506746.1_Silent_p.Y184Y|LPHN3_ENST00000514591.1_Silent_p.Y116Y|LPHN3_ENST00000545650.1_Silent_p.Y116Y|LPHN3_ENST00000508693.1_Silent_p.Y184Y|LPHN3_ENST00000504896.1_Silent_p.Y116Y|LPHN3_ENST00000514996.1_Silent_p.Y116Y|LPHN3_ENST00000511324.1_Silent_p.Y184Y|LPHN3_ENST00000507625.1_Silent_p.Y184Y|LPHN3_ENST00000509896.1_Silent_p.Y184Y|LPHN3_ENST00000508946.1_Silent_p.Y116Y|LPHN3_ENST00000506720.1_Silent_p.Y184Y|LPHN3_ENST00000506700.1_Silent_p.Y116Y|LPHN3_ENST00000514157.1_Silent_p.Y116Y			Q9HAR2	LPHN3_HUMAN	latrophilin 3	116	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CCTATAAATACCTTGAAGTGC	0.398000													47	194					0	0	1	0	0
POU2F3	25833	broad.mit.edu	37	11	120169044	120169044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120169044G>A	ENST00000260264.4	+	4	243	c.209G>A	c.(208-210)gGa>gAa	p.G70E	POU2F3_ENST00000543440.2_Missense_Mutation_p.G68E	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	68					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		CTGAGTCAAGGACCTGCCATG	0.522000													105	161					0	0	1	0	0
KLF11	8462	broad.mit.edu	37	2	10186390	10186390	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:10186390T>A	ENST00000535335.1	+	2	321	c.105T>A	c.(103-105)gtT>gtA	p.V35V	KLF11_ENST00000305883.1_Silent_p.V52V|KLF11_ENST00000540845.1_Silent_p.V35V	NM_001177718.1	NP_001171189.1	O14901	KLF11_HUMAN	Kruppel-like factor 11	52					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		AGGCTCTTGTTTGTATGAGCT	0.537000													31	51					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21954013	21954013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21954013C>T	ENST00000261200.4	-	38	4614	c.4615G>A	c.(4615-4617)Gga>Aga	p.G1539R		NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1539	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCAAATACTCCATTTTCCTGA	0.378000													17	56					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3730588	3730588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3730588G>A	ENST00000541714.2	+	5	959	c.497G>A	c.(496-498)gGt>gAt	p.G166D	TJP3_ENST00000262968.9_Missense_Mutation_p.G185D|TJP3_ENST00000587686.1_Missense_Mutation_p.G185D|TJP3_ENST00000589378.1_Missense_Mutation_p.G175D|TJP3_ENST00000539908.2_Missense_Mutation_p.G130D|TJP3_ENST00000382008.3_Missense_Mutation_p.G166D	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	166						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGAGCCCAGGTGGTGGCTCT	0.706000													16	59					0	0	1	0	0
PTTG2	10744	broad.mit.edu	37	4	37962103	37962103	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:37962103C>T	ENST00000504686.1	+	1	48	c.48C>T	c.(46-48)acC>acT	p.T16T	TBC1D1_ENST00000261439.4_Intron|TBC1D1_ENST00000508802.1_Intron	NM_006607.2	NP_006598.2	Q9NZH5	PTTG2_HUMAN	pituitary tumor-transforming 2	16					chromosome organization|DNA metabolic process	cytoplasm|nucleus	SH3 domain binding			breast(1)|endometrium(1)|lung(4)|skin(1)	7						AACCAGGCACCCGTGTGGCTG	0.463000													4	55					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24372859	24372859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24372859G>A	ENST00000005284.3	+	4	1825	c.623G>A	c.(622-624)cGa>cAa	p.R208Q		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	208					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CAGCAGTTACGAGCCAAATCC	0.488000													29	103					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88669548	88669548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88669548G>A	ENST00000394480.1	-	13	1671	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F	NTRK3_ENST00000558676.1_Silent_p.F442F|NTRK3_ENST00000357724.2_Silent_p.F442F|NTRK3_ENST00000317501.3_Silent_p.F450F|NTRK3_ENST00000355254.2_Silent_p.F450F|NTRK3_ENST00000558306.1_Intron|NTRK3_ENST00000542733.2_Silent_p.F352F|NTRK3_ENST00000540489.2_Silent_p.F450F|NTRK3_ENST00000360948.2_Silent_p.F450F|NTRK3_ENST00000557856.1_Silent_p.F442F	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	450					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGATCATGACGAAGAGAACCA	0.453000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			22	58					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224437953	224437953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:224437953G>A	ENST00000281701.6	-	19	2509	c.2250C>T	c.(2248-2250)ccC>ccT	p.P750P	NVL_ENST00000340871.4_Silent_p.P561P|NVL_ENST00000391875.2_Silent_p.P644P|NVL_ENST00000361463.3_3'UTR|NVL_ENST00000469075.1_Silent_p.P659P|NVL_ENST00000482491.1_Silent_p.P474P	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	750						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		GATCTGCAGGGGGCGGTAAAC	0.398000													22	80					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100458845	100458845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100458845C>T	ENST00000354161.3	+	10	1429	c.1304C>T	c.(1303-1305)tCc>tTc	p.S435F	SLC12A9_ENST00000415287.1_Missense_Mutation_p.S346F|SLC12A9_ENST00000428758.1_Missense_Mutation_p.S435F|SLC12A9_ENST00000275729.3_Missense_Mutation_p.S346F|SLC12A9_ENST00000540482.1_Missense_Mutation_p.S435F	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	435						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					GTGGACCTGTCCTGCCTGAGC	0.632000													42	121					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135382142	135382142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135382142C>T	ENST00000442011.2	+	4	578	c.417C>T	c.(415-417)acC>acT	p.T139T	TGFBI_ENST00000305126.8_Silent_p.T139T	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	139	FAS1 1.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCAGCTTCACCATCTTCGCCC	0.622000													9	24					0	0	1	0	0
FAM189A2	9413	broad.mit.edu	37	9	72000820	72000820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72000820C>T	ENST00000257515.8	+	9	1233	c.813C>T	c.(811-813)acC>acT	p.T271T	FAM189A2_ENST00000303068.7_Silent_p.T106T|FAM189A2_ENST00000455972.1_Silent_p.T271T|FAM189A2_ENST00000469179.1_3'UTR	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	271						integral to membrane				endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CCTTGAGGACCAGGTCGAAGA	0.547000													10	33					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19483563	19483563	+	Missense_Mutation	SNP	G	G	A	rs142982513		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19483563G>A	ENST00000396229.2	+	11	2685	c.1936G>A	c.(1936-1938)Gag>Aag	p.E646K	TMC5_ENST00000542583.2_Missense_Mutation_p.E646K|TMC5_ENST00000564959.1_Missense_Mutation_p.E329K|TMC5_ENST00000561503.1_Missense_Mutation_p.E287K|TMC5_ENST00000219821.5_Missense_Mutation_p.E400K|TMC5_ENST00000541464.1_Intron|TMC5_ENST00000381414.4_Missense_Mutation_p.E646K	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	646						integral to membrane		p.E400K(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GTACAACTTAGAGGTAACCAA	0.562000													21	39					0	0	1	0	0
PRTN3	5657	broad.mit.edu	37	19	841055	841055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:841055C>T	ENST00000234347.5	+	1	93	c.47C>T	c.(46-48)gCc>gTc	p.A16V		NM_002777.3	NP_002768.3	P24158	PRTN3_HUMAN	proteinase 3	16					collagen catabolic process|positive regulation of cell proliferation|proteolysis		protein binding|serine-type endopeptidase activity			lung(1)|ovary(2)|urinary_tract(1)	4		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCTGCTGGCCTTGCTGCTG	0.652000													7	18					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155234488	155234488	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155234488G>A	ENST00000368361.4	-	9	1326	c.1011C>T	c.(1009-1011)caC>caT	p.H337H	CLK2_ENST00000361168.5_Silent_p.H336H|CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000355560.4_Silent_p.H335H|CLK2_ENST00000536801.1_Silent_p.H337H			P49760	CLK2_HUMAN	CDC-like kinase 2	337	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGTGCTATGGTGCTCATGGT	0.547000								Other conserved DNA damage response genes					28	73					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111156291	111156291	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111156291C>T	ENST00000360467.5	+	44	4542	c.4236C>T	c.(4234-4236)ccC>ccT	p.P1412P	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1412	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGCGAGGCCCCCCTGGGGCAC	0.736000													5	55					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51347726	51347726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51347726G>A	ENST00000266037.9	+	28	3009	c.2986G>A	c.(2986-2988)Gac>Aac	p.D996N		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	996						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CTTCCCTCGGGACTGGATGGT	0.463000													5	17					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34129929	34129929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34129929C>T	ENST00000389232.4	+	89	11818	c.11748C>T	c.(11746-11748)ttC>ttT	p.F3916F	RYR3_ENST00000415757.3_Silent_p.F3911F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3916					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGACATGTTCTTGAAACTTA	0.393000													11	16					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436483	56436483	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:56436483C>T	ENST00000327381.5	+	3	1750	c.1650C>T	c.(1648-1650)tcC>tcT	p.S550S		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	550						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			GGTCCATCTCCAACAACCGCA	0.592000													12	77					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17668875	17668875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17668875C>T	ENST00000375448.4	+	8	939	c.913C>T	c.(913-915)Ccg>Tcg	p.P305S	AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	305					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CACCCAGCCCCCGCAGGAGGT	0.642000													5	57					0	0	1	0	0
DAO	1610	broad.mit.edu	37	12	109283259	109283259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109283259G>A	ENST00000228476.3	+	4	528	c.324G>A	c.(322-324)aaG>aaA	p.K108K	DAO_ENST00000551281.1_Intron	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	108					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						CTTCCTGGAAGGACACAGTTC	0.537000													18	65					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31497190	31497190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31497190C>T	ENST00000330498.3	+	4	463	c.444C>T	c.(442-444)ttC>ttT	p.F148F		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	148					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						TCTCCCTTTTCCTGTACATCT	0.602000													13	54					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729932	18729932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18729932C>T	ENST00000440756.2	-	3	544	c.442G>A	c.(442-444)Gga>Aga	p.G148R	PSD3_ENST00000327040.8_Missense_Mutation_p.G148R|PSD3_ENST00000523619.1_Missense_Mutation_p.G83R			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	148					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TGTAATGTTCCGGAAATGATT	0.453000													21	156					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834305	101834305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101834305C>T	ENST00000506729.1	-	1	415	c.244G>A	c.(244-246)Gat>Aat	p.D82N	SLCO6A1_ENST00000379810.1_Missense_Mutation_p.D82N|SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.D82N|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.D82N|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.D82N			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	82						integral to membrane|plasma membrane	transporter activity	p.D82H(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AAACTGTCATCCACTTCTCCC	0.493000													53	114					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	163581	163581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:163581C>T	ENST00000283426.6	+	11	2376	c.2326C>T	c.(2326-2328)Ccc>Tcc	p.P776S		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	776					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TGCCAGGAGCCCCCCGGTCAC	0.652000													15	34					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17599924	17599924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17599924C>T	ENST00000375460.3	+	10	1177	c.1137C>T	c.(1135-1137)ttC>ttT	p.F379F		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	379					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGCAGGATTTCCCTTACAAAA	0.617000													21	34					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141509	133141509	+	Nonstop_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133141509T>G	ENST00000388996.4	-	15	3039	c.2619A>C	c.(2617-2619)taA>taC	p.*873Y	KCNQ3_ENST00000519445.1_Nonstop_Mutation_p.*861Y|KCNQ3_ENST00000521134.1_Nonstop_Mutation_p.*753Y	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	0					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTGACCTCTTTTAAATGGGCT	0.532000													14	51					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117803253	117803253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117803253C>T	ENST00000350763.4	-	19	5770	c.5359G>A	c.(5359-5361)Gaa>Aaa	p.E1787K	TNC_ENST00000341037.4_Missense_Mutation_p.E1605K|TNC_ENST00000542877.1_Missense_Mutation_p.E1424K|TNC_ENST00000340094.3_Missense_Mutation_p.E1423K|TNC_ENST00000537320.1_Missense_Mutation_p.E1150K|TNC_ENST00000535648.1_Missense_Mutation_p.E1332K|TNC_ENST00000423613.2_Missense_Mutation_p.E1514K|TNC_ENST00000345230.3_Missense_Mutation_p.E1150K|TNC_ENST00000346706.3_Missense_Mutation_p.E1241K	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1787	Fibronectin type-III 13.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GGTTCACTTTCCTCAAAGCCC	0.498000													29	80					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183097158	183097158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183097158C>T	ENST00000328913.3	-	3	499	c.202G>A	c.(202-204)Gag>Aag	p.E68K	MCF2L2_ENST00000447025.2_Missense_Mutation_p.E68K|MCF2L2_ENST00000473233.1_Missense_Mutation_p.E68K|MCF2L2_ENST00000414362.2_Missense_Mutation_p.E68K	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	68	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CCCGAAAACTCTGGGAACGTG	0.532000													12	26					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42149979	42149979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42149979C>T	ENST00000401548.3	+	17	1920	c.1880C>T	c.(1879-1881)tCc>tTc	p.S627F	MEI1_ENST00000540833.1_Missense_Mutation_p.S367F|MEI1_ENST00000540880.1_Intron|MEI1_ENST00000400107.1_5'UTR|MEI1_ENST00000300398.4_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	627							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CAGGTGTGTTCCAATTTCCTC	0.448000													41	61					0	0	1	0	0
SYNGR3	9143	broad.mit.edu	37	16	2042728	2042728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2042728G>A	ENST00000562045.1	+	2	1180	c.164G>A	c.(163-165)gGg>gAg	p.G55E	SYNGR3_ENST00000248121.2_Silent_p.G143G			O43761	SNG3_HUMAN	synaptogyrin 3	0	MARVEL.				positive regulation of transporter activity	cell junction|integral to plasma membrane|synaptic vesicle				endometrium(1)|lung(2)	3						CGCAGGCGGGGGACGCGGCGC	0.716000													7	7					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117103972	117103972	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117103972G>A	ENST00000307564.4	-	21	4069	c.3908C>T	c.(3907-3909)tCt>tTt	p.S1303F	AKNA_ENST00000374075.5_Missense_Mutation_p.S1222F|AKNA_ENST00000374079.4_Missense_Mutation_p.S248F|AKNA_ENST00000492875.1_5'UTR|AKNA_ENST00000374088.3_Missense_Mutation_p.S1303F|AKNA_ENST00000223791.3_Missense_Mutation_p.S763F	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1303			S -> P (in dbSNP:rs2250242).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GGGAGTTGAAGATGCTTTTCT	0.622000													16	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179456479	179456479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179456479C>T	ENST00000589042.1	-	303	60291	c.60067G>A	c.(60067-60069)Gac>Aac	p.D20023N	TTN_ENST00000342992.6_Missense_Mutation_p.D17455N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D10958N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D11150N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D11083N|TTN_ENST00000591111.1_Missense_Mutation_p.D18382N|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18382	Fibronectin type-III 45.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAATCCAGTCCTGGGTGCCT	0.413000													39	99					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45461956	45461956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:45461956C>T	ENST00000303230.4	-	3	1060	c.1003G>A	c.(1003-1005)Gaa>Aaa	p.E335K		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	335						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ACAACCATTTCATTTAAAGAC	0.398000													15	33					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152490375	152490375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152490375G>A	ENST00000427231.2	-	65	9409	c.9207C>T	c.(9205-9207)atC>atT	p.I3069I	NEB_ENST00000409198.1_Intron|NEB_ENST00000397345.3_Silent_p.I3069I|NEB_ENST00000604864.1_Silent_p.I3069I|NEB_ENST00000172853.10_Intron|NEB_ENST00000603639.1_Silent_p.I3069I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3069					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTCACTCTGGATCTTGGCTA	0.502000													110	330					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118105316	118105316	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:118105316G>A	ENST00000425217.1	-	5	1101	c.1047C>T	c.(1045-1047)tcC>tcT	p.S349S	KSR2_ENST00000302438.5_Silent_p.S75S|KSR2_ENST00000339824.5_Silent_p.S378S|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	378					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGGAGGGGTGGAAGGCAGGA	0.627000													3	14					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37346323	37346323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:37346323G>A	ENST00000373091.3	-	3	478	c.462C>T	c.(460-462)ccC>ccT	p.P154P	GRIK3_ENST00000373093.4_Silent_p.P154P	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	154					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AGGCGTAGTCGGGGTAGAGGT	0.607000													48	118					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606135	21606135	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:21606135C>T	ENST00000281523.2	-	3	725	c.207G>A	c.(205-207)ggG>ggA	p.G69G	ZNF385D-AS1_ENST00000412369.1_RNA|ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	69						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						GAAGAGGAACCCCGAATGTAT	0.343000													24	84					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46267842	46267842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:46267842C>T	ENST00000372004.3	+	14	2819	c.2603C>T	c.(2602-2604)cCt>cTt	p.P868L	NCOA3_ENST00000341724.6_Intron|NCOA3_ENST00000371998.3_Missense_Mutation_p.P868L|NCOA3_ENST00000371997.3_Missense_Mutation_p.P878L	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	868					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GGCTCAAGTCCTCCAGTAAAA	0.433000													36	81					0	0	1	0	0
MMP19	4327	broad.mit.edu	37	12	56235010	56235010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56235010C>T	ENST00000322569.4	-	3	275	c.184G>A	c.(184-186)Gaa>Aaa	p.E62K	MMP19_ENST00000548629.1_Missense_Mutation_p.E62K|MMP19_ENST00000547487.1_5'UTR|MMP19_ENST00000409200.3_Missense_Mutation_p.E62K	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	62					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						TCAGATGCTTCCTGAAAAGCT	0.527000													22	55					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68688074	68688074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68688074C>T	ENST00000283916.6	-	10	1336	c.1238G>A	c.(1237-1239)aGg>aAg	p.R413K	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11D_ENST00000545541.1_Missense_Mutation_p.R296K	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	413	Peptidase S1.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						AGTTTGTTGCCTAATCCAGTC	0.463000													13	214					0	0	1	0	0
SWAP70	23075	broad.mit.edu	37	11	9715787	9715787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:9715787C>T	ENST00000318950.6	+	2	297	c.194C>T	c.(193-195)tCc>tTc	p.S65F	SWAP70_ENST00000447399.2_Missense_Mutation_p.S65F	NM_015055.2	NP_055870.2	Q9UH65	SWP70_HUMAN	SWAP switching B-cell complex 70kDa subunit	65						cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	11				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		GGTCCAGTGTCCAACCAGGGC	0.453000													25	107					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145095669	145095669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145095669C>T	ENST00000377470.3	+	3	1069	c.967C>T	c.(967-969)Ccc>Tcc	p.P323S	SPATC1_ENST00000447830.2_Missense_Mutation_p.P323S	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	323										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			tgcatctgtccccacctcccc	0.662000													6	18					0	0	1	0	0
SULT1C4	27233	broad.mit.edu	37	2	108999633	108999633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108999633G>A	ENST00000272452.2	+	4	804	c.478G>A	c.(478-480)Gga>Aga	p.G160R	SULT1C4_ENST00000409309.3_Intron	NM_006588.2	NP_006579.2	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member 4	160					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						TCCTGCTCCAGGAACATGGGA	0.413000													52	93					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52556489	52556489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52556489G>A	ENST00000261839.7	-	9	1106	c.945C>T	c.(943-945)ttC>ttT	p.F315F	MYO5C_ENST00000541028.1_5'UTR|MYO5C_ENST00000443683.2_Silent_p.F258F	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	315	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AATCCTCCTTGAAACCTAAAA	0.443000													11	31					0	0	1	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261887	21261887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21261887G>A	ENST00000311620.5	+	2	1073	c.1000G>A	c.(1000-1002)Gat>Aat	p.D334N		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	334								p.D334N(1)		NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		GTGGGATGACGATGAAGTGGA	0.517000													17	32					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6912853	6912853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6912853C>T	ENST00000299459.2	-	1	977	c.879G>A	c.(877-879)aaG>aaA	p.K293K		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K293K(1)		breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCTTCACATCCTTGTTTCTCA	0.458000													23	62					0	0	1	0	0
CST4	1472	broad.mit.edu	37	20	23667831	23667831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23667831C>T	ENST00000217423.3	-	2	306	c.236G>A	c.(235-237)gGg>gAg	p.G79E		NM_001899.2	NP_001890.1	P01036	CYTS_HUMAN	cystatin S	79						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	16	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					ATTCACCCCCCCAAAGGTCTG	0.552000													45	186					0	0	1	0	0
GCLC	2729	broad.mit.edu	37	6	53364951	53364951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:53364951G>A	ENST00000229416.6	-	15	2077	c.1594C>T	c.(1594-1596)Cct>Tct	p.P532S		NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	532					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	ATCAGTCCAGGAAACACACCT	0.478000													20	108					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153221832	153221832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153221832G>A	ENST00000310441.7	-	16	3632	c.2666C>T	c.(2665-2667)aCc>aTc	p.T889I	HCFC1_ENST00000354233.3_Missense_Mutation_p.T820I|HCFC1_ENST00000369984.4_Missense_Mutation_p.T889I	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	889	Interaction with GABP2.|Interaction with ZBTB17.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGTGGAGACGGTGCCTGTCAC	0.642000													10	48					0	0	1	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33016598	33016598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33016598G>A	ENST00000357505.6	-	7	2135	c.2031C>T	c.(2029-2031)tcC>tcT	p.S677S	N4BP2L2_ENST00000380121.3_5'UTR|N4BP2L2_ENST00000446957.2_Silent_p.S595S|N4BP2L2_ENST00000504114.1_Silent_p.S677S|N4BP2L2_ENST00000399396.3_Silent_p.S692S	NM_001278432.1	NP_001265361.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	0										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GTAGCTCAAGGGAACGGTAGT	0.393000													7	22					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50339780	50339780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50339780C>T	ENST00000376020.2	-	9	4422	c.4397G>A	c.(4396-4398)cGa>cAa	p.R1466Q	SHROOM4_ENST00000289292.7_Missense_Mutation_p.R1466Q|SHROOM4_ENST00000460112.3_Missense_Mutation_p.R1350Q	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1466	ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					CTCCAGCTCTCGCTGTTCAAT	0.502000													21	17					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57866755	57866755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57866755C>T	ENST00000443917.2	+	3	616	c.277C>T	c.(277-279)Cct>Tct	p.P93S	ZNF304_ENST00000391705.3_Intron|ZNF304_ENST00000282286.5_Intron|ZNF304_ENST00000598744.1_Intron			Q9HCX3	ZN304_HUMAN	zinc finger protein 304	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		AGGGCATGGCCCTGCTGAATG	0.522000													13	50					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8235340	8235340	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8235340G>A	ENST00000520004.1	-	3	843	c.579C>T	c.(577-579)ccC>ccT	p.P193P	SGK223_ENST00000330777.4_Silent_p.P193P			Q86YV5	SG223_HUMAN		193							ATP binding|non-membrane spanning protein tyrosine kinase activity										AAGGAAATGAGGGTTTTTCTT	0.617000													30	90					0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223226	35223226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35223226G>A	ENST00000338513.1	+	2	468	c.295G>A	c.(295-297)Gag>Aag	p.E99K		NM_005268.3	NP_005259.1	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	99					cell communication|epidermis development	connexon complex|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				GGCCTACCGGGAGGTTCAGGA	0.612000													26	77					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369416	56369416	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56369416C>T	ENST00000301295.6	+	3	1079	c.657C>T	c.(655-657)atC>atT	p.I219I	NLRP4_ENST00000346986.5_Silent_p.I219I|NLRP4_ENST00000587891.1_Silent_p.I144I	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	219	NACHT.						ATP binding	p.I219I(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TAACAGAGATCGTGTCTCAAC	0.537000													38	84					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155212010	155212010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155212010C>T	ENST00000460012.1	-	17	2369	c.2012G>A	c.(2011-2013)cGa>cAa	p.R671Q	PLCH1_ENST00000334686.6_Missense_Mutation_p.R671Q|PLCH1_ENST00000494598.1_Missense_Mutation_p.R689Q|PLCH1_ENST00000447496.2_Missense_Mutation_p.R689Q|PLCH1_ENST00000340059.7_Missense_Mutation_p.R689Q|PLCH1_ENST00000414191.1_Missense_Mutation_p.R671Q			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	689	PI-PLC Y-box.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CTGCATCATTCGTCCTTCAGA	0.418000													21	73					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39913526	39913526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39913526C>T	ENST00000425673.1	+	16	2070	c.1745C>T	c.(1744-1746)cCa>cTa	p.P582L	PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.P552L|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.P611L			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	611					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGGCCTTCCCCACTCCACGTC	0.562000													15	47					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913201	6913201	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6913201G>A	ENST00000299459.2	-	1	629	c.531C>T	c.(529-531)ttC>ttT	p.F177F		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCTCACAAAAGAAATGAGCAA	0.493000													9	54					0	0	1	0	0
CD74	972	broad.mit.edu	37	5	149792299	149792299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149792299C>T	ENST00000353334.6	-	1	193	c.14G>A	c.(13-15)aGa>aAa	p.R5K	CD74_ENST00000377795.3_Missense_Mutation_p.R5K|CD74_ENST00000009530.7_Missense_Mutation_p.R5K|CD74_ENST00000524315.1_Missense_Mutation_p.R5K	NM_001025159.2|NM_004355.3	NP_001020330.1|NP_004346.1	P04233	HG2A_HUMAN	CD74 molecule, major histocompatibility complex, class II invariant chain	5					antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTCCTGCTTCTCCTCCTGTG	0.607000			T	ROS1	NSCLC								97	222					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56910937	56910937	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:56910937G>A	ENST00000520220.2	+	11	1294	c.1020G>A	c.(1018-1020)aaG>aaA	p.K340K	LYN_ENST00000420292.1_3'UTR|LYN_ENST00000519728.1_Silent_p.K361K	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	361	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			TCGAGCGGAAGAACTACATTC	0.448000													16	48					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43936011	43936011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43936011G>A	ENST00000262726.7	-	28	4128	c.3875C>T	c.(3874-3876)cCc>cTc	p.P1292L	EFCAB6_ENST00000396231.2_Missense_Mutation_p.P1140L|EFCAB6_ENST00000461800.1_5'UTR	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				ACTCACACAGGGGTGGCTCTG	0.612000													12	57					0	0	1	0	0
GLS2	27165	broad.mit.edu	37	12	56868895	56868895	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56868895C>T	ENST00000311966.4	-	10	1208		c.e10-1		GLS2_ENST00000476991.1_Splice_Site	NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)						cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TGACTGGAATCTGAAGCAAAC	0.468000													66	133					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51890209	51890209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51890209C>T	ENST00000371117.3	-	32	4674	c.4399G>A	c.(4399-4401)Ggg>Agg	p.G1467R	PKHD1_ENST00000340994.4_Missense_Mutation_p.G1467R	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1467	IPT/TIG 9.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTGGTTAGCCCATTGACCAGG	0.537000													18	33					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39724454	39724454	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39724454C>T	ENST00000246662.4	-	6	1419	c.1354G>A	c.(1354-1356)Gag>Aag	p.E452K	KRT9_ENST00000588431.1_Missense_Mutation_p.E219K	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	452	Coil 2.|Rod.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				TGGTAGGTCTCGATTTCCTTC	0.552000													20	24					0	0	1	0	0
NKX6-1	4825	broad.mit.edu	37	4	85419214	85419214	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85419214G>A	ENST00000295886.4	-	1	389	c.168C>T	c.(166-168)tcC>tcT	p.S56S		NM_006168.2	NP_006159.2	P78426	NKX61_HUMAN	NK6 homeobox 1	56	Poly-Ser.				detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	15		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)		gcgacgaggaggacgacgacg	0.746000													4	4					0	0	1	0	0
BBC3	27113	broad.mit.edu	37	19	47725025	47725025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47725025G>A	ENST00000449228.1	-	4	882	c.719C>T	c.(718-720)tCg>tTg	p.S240L	BBC3_ENST00000341983.4_3'UTR|BBC3_ENST00000439096.2_3'UTR|BBC3_ENST00000300880.7_Missense_Mutation_p.S80L	NM_001127240.2	NP_001120712.1	Q9BXH1	BBC3_HUMAN	BCL2 binding component 3	0					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to hypoxia|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of growth|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|positive regulation of thymocyte apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|reduction of endoplasmic reticulum calcium ion concentration|release of cytochrome c from mitochondria|release of sequestered calcium ion into cytosol	cytosol|mitochondrial outer membrane	protein binding			endometrium(1)|lung(2)|skin(1)	4		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.000179)|OV - Ovarian serous cystadenocarcinoma(262;0.00029)|Epithelial(262;0.0103)|GBM - Glioblastoma multiforme(486;0.0234)		CCTGCCCCCCGAGTCCCTGAC	0.672000													9	15					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103471421	103471421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103471421C>T	ENST00000358392.2	-	18	2171	c.1854G>A	c.(1852-1854)ccG>ccA	p.P618P	COL11A1_ENST00000370096.3_Silent_p.P606P|COL11A1_ENST00000512756.1_Silent_p.P490P|COL11A1_ENST00000353414.4_Silent_p.P567P|COL11A1_ENST00000461720.1_5'UTR	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	606	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.P606P(2)|p.P618P(2)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGCAGACCCGGAAGTCCAT	0.358000													22	123					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1496876	1496876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1496876G>A	ENST00000421627.2	+	2	151	c.17G>A	c.(16-18)gGa>gAa	p.G6E		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	85					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GGCCTTTCCGGAAGTCGGACC	0.692000													4	14					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32752402	32752402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32752402G>A	ENST00000380250.3	+	21	3006	c.2510G>A	c.(2509-2511)aGc>aAc	p.S837N		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	837					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GATGTGAAAAGCCCTTCCCAT	0.512000													13	131					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018171	62018171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62018171C>T	ENST00000578147.1	-	24	5547	c.5471G>A	c.(5470-5472)gGg>gAg	p.G1824E	SCN4A_ENST00000435607.1_Missense_Mutation_p.G1824E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1824					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CACAGTCTGCCCTGGGGGAGG	0.682000													5	63					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024332	76024332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76024332C>T	ENST00000393004.2	-	5	1437	c.1216G>A	c.(1216-1218)Gaa>Aaa	p.E406K	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.E406K|FILIP1_ENST00000370020.1_Missense_Mutation_p.E307K			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	406										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TTCCTCAATTCCCTACACTGG	0.423000													14	143					0	0	1	0	0
FAM45B	55855	broad.mit.edu	37	X	129629752	129629752	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:129629752G>A	ENST00000458525.1	-	0	1015				FAM45B_ENST00000592932.1_RNA																							GTGTGGCACCGACAGGACTGG	0.537000													18	36					0	0	1	0	0
VGLL2	245806	broad.mit.edu	37	6	117586980	117586980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117586980C>T	ENST00000326274.5	+	1	244	c.54C>T	c.(52-54)ttC>ttT	p.F18F	VGLL2_ENST00000352536.3_Silent_p.F18F	NM_182645.2	NP_872586.1	Q8N8G2	VGLL2_HUMAN	vestigial like 2 (Drosophila)	18					transcription, DNA-dependent	nucleus				central_nervous_system(1)|kidney(1)|lung(3)	5				GBM - Glioblastoma multiforme(226;0.0254)|all cancers(137;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.0757)		AGCCCTACTTCGCAGCCGCCT	0.577000													11	21					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22291883	22291883	+	Nonsense_Mutation	SNP	C	C	T	rs146341538		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:22291883C>T	ENST00000324559.8	+	18	2241	c.1924C>T	c.(1924-1926)Cga>Tga	p.R642*		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	642						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTGGAGACGCCGAAAAGCTCG	0.418000													22	81					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172674507	172674507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172674507G>A	ENST00000351008.3	-	6	1224	c.1041C>T	c.(1039-1041)ttC>ttT	p.F347F		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	347					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			GAGTTTTTGTGAAAGCATCTT	0.333000													18	43					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155486985	155486985	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155486985G>A	ENST00000302068.4	+	2	203	c.140G>A	c.(139-141)cGa>cAa	p.R47Q	FGB_ENST00000509493.1_Intron|FGB_ENST00000502545.1_3'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	47	Beta-chain polymerization, binding distal domain of another fibrin.		Missing (in New York-1).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CGTGGTCATCGACCCCTTGAC	0.522000													7	56					0	0	1	0	0
GABRA5	2558	broad.mit.edu	37	15	27128577	27128577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:27128577C>T	ENST00000335625.5	+	6	1258	c.370C>T	c.(370-372)Ctt>Ttt	p.L124F	GABRA5_ENST00000355395.5_Missense_Mutation_p.L124F|GABRA5_ENST00000400081.3_Missense_Mutation_p.L124F|GABRB3_ENST00000541819.2_Intron|GABRA5_ENST00000557449.1_Intron	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	124					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAACAACCTCCTTGCCAGCAA	0.547000													23	80					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220503474	220503474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220503474C>T	ENST00000358055.3	+	19	3418	c.2906C>T	c.(2905-2907)tCg>tTg	p.S969L	SLC4A3_ENST00000273063.6_Missense_Mutation_p.S996L|SLC4A3_ENST00000373760.2_Missense_Mutation_p.S969L|SLC4A3_ENST00000373762.3_Missense_Mutation_p.S996L|SLC4A3_ENST00000317151.3_Missense_Mutation_p.S969L			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	969	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GATAAGCGCTCGTGGTTCATC	0.602000													18	53					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	57016149	57016149	+	Splice_Site	SNP	C	C	T	rs111642444		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57016149C>T	ENST00000200676.3	+	14	1451	c.1321_splice	c.e14+1	p.R441_splice	CETP_ENST00000379780.2_Splice_Site_p.R381_splice|CETP_ENST00000566128.1_Splice_Site_p.R376_splice	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	441					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						GGTCATGTCTCGTAAGTGTGG	0.592000													16	55					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140235691	140235691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140235691C>T	ENST00000307360.5	+	1	58	c.58C>T	c.(58-60)Ctc>Ttc	p.L20F	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.L20F|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTCTTCTCCTCGCAGCCTG	0.592000													18	51					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111342415	111342415	+	Missense_Mutation	SNP	G	G	A	rs138877502		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111342415G>A	ENST00000308208.5	+	11	1608	c.1366G>A	c.(1366-1368)Gac>Aac	p.D456N	CCDC63_ENST00000552694.1_Missense_Mutation_p.D377N|CCDC63_ENST00000545036.1_Missense_Mutation_p.D416N	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	456								p.D456N(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GAAGACCAACGACCTGCTGCT	0.597000													32	90					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70118404	70118404	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70118404C>T	ENST00000253925.7	+	2	341	c.126C>T	c.(124-126)tcC>tcT	p.S42S	PPFIA1_ENST00000389547.3_Silent_p.S42S	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	42					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGATGGTCTCCATGCTAGAAG	0.532000													20	104					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94100891	94100891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94100891G>A	ENST00000553484.1	+	33	5961	c.5807G>A	c.(5806-5808)gGa>gAa	p.G1936E	UNC79_ENST00000555664.1_Intron|UNC79_ENST00000393151.2_Missense_Mutation_p.G1914E|UNC79_ENST00000256339.4_Missense_Mutation_p.G1737E			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1914						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ATGAAAAGGGGATCCCTGGGA	0.468000													31	78					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94134036	94134036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94134036G>A	ENST00000243673.2	-	1	549	c.378C>T	c.(376-378)ccC>ccT	p.P126P	GPR83_ENST00000539203.2_Silent_p.P126P	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	126						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCAAAGTGAAGGGGGTGTTGA	0.577000													12	25					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79028721	79028721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79028721C>T	ENST00000446378.2	+	2	4164	c.4133C>T	c.(4132-4134)tCt>tTt	p.S1378F		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1378						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ACAGATTCATCTCTTATCACT	0.393000													16	30					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348411	140348411	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348411T>C	ENST00000289269.5	+	1	2592	c.2060T>C	c.(2059-2061)aTc>aCc	p.I687T	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		687	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTCCAAAATCCTCCCTGAC	0.443000													21	61					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92928218	92928218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:92928218G>A	ENST00000373079.3	-	1	349	c.86C>T	c.(85-87)tCt>tTt	p.S29F	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	29	Ser-rich.				nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TTCTTCCCCAGAATCACTAGT	0.557000													19	21					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42161469	42161469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42161469G>A	ENST00000444063.1	+	9	1203	c.1071G>A	c.(1069-1071)atG>atA	p.M357I	L3MBTL1_ENST00000373134.1_Missense_Mutation_p.M357I|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.M425I|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.M357I|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.M425I			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	357					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						TTGACCGCATGAACCCGTCCC	0.587000													17	212					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36361338	36361338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36361338C>T	ENST00000405275.2	+	3	250	c.7C>T	c.(7-9)Cgg>Tgg	p.R3W	CTNNBL1_ENST00000361383.6_Missense_Mutation_p.R30W			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	30					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				GAAGATGCGTCGGAAACAAAC	0.478000													20	62					0	0	1	0	0
RIN2	54453	broad.mit.edu	37	20	19981479	19981479	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19981479C>T	ENST00000255006.6	+	12	2883	c.2734C>T	c.(2734-2736)Cga>Tga	p.R912*	RIN2_ENST00000440354.2_Nonsense_Mutation_p.R430*|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	863					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						GCTGCACAGCCGACCACAGCC	0.522000													13	64					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62045598	62045598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62045598C>T	ENST00000578147.1	-	6	897	c.821G>A	c.(820-822)gGa>gAa	p.G274E	SCN4A_ENST00000435607.1_Missense_Mutation_p.G274E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	274					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CCTCAGGTTTCCCATGAAGAG	0.562000													31	84					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665909	19665909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19665909G>A	ENST00000328041.6	+	12	1425	c.1228G>A	c.(1228-1230)Gaa>Aaa	p.E410K		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	410						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGCTGGCAACGAAACAgagaa	0.537000													20	44					0	0	1	0	0
PDCL2	132954	broad.mit.edu	37	4	56435940	56435940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:56435940C>T	ENST00000295645.4	-	4	409	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K		NM_152401.2	NP_689614.2	Q8N4E4	PDCL2_HUMAN	phosducin-like 2	103										endometrium(1)|kidney(1)|lung(4)|ovary(1)	7	Lung NSC(11;0.00256)|Glioma(25;0.08)|all_epithelial(27;0.0863)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.69e-07)|Lung(4;1.03e-06)|Epithelial(7;0.00669)			TTTGTGACTTCATTCACATAC	0.279000													5	7					0	0	1	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170165	20170165	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20170165G>A	ENST00000338912.5	-	0	106																											GATCCTCACTGAGGCCCCAGG	0.572000													32	57					0	0	1	0	0
LOC653786	653786	broad.mit.edu	37	16	22558274	22558274	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:22558274C>T	ENST00000550753.1	+	0	1256					NR_003676.2																						TGGTTATTATCTCTTTTTAGA	0.433000													10	80					0	0	1	0	0
KLRD1	3824	broad.mit.edu	37	12	10462072	10462072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10462072G>A	ENST00000381908.3	+	2	353	c.93G>A	c.(91-93)ttG>ttA	p.L31L	KLRD1_ENST00000538997.1_Intron|KLRD1_ENST00000543777.1_Silent_p.L31L|KLRD1_ENST00000350274.5_Intron|KLRD1_ENST00000381907.4_Silent_p.L31L|KLRD1_ENST00000336164.4_Silent_p.L31L|KLRD1_ENST00000543420.1_Silent_p.L31L			Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D, member 1	31					cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	10						GAATTTTGTTGAAAAATTGTA	0.328000													21	39					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537083	5537083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5537083C>T	ENST00000380184.1	-	1	852	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	197								p.E197*(1)		endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		TCTAGATGTTCTGAAATGAAC	0.493000													52	134					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378682	114378682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:114378682C>T	ENST00000312719.5	-	5	1968	c.780G>A	c.(778-780)acG>acA	p.T260T	HS3ST5_ENST00000411826.1_Silent_p.T260T|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	260					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GCAGAGGTTCCGTGATGAGGC	0.428000													22	45					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80223044	80223044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:80223044G>A	ENST00000392959.1	-	4	1216	c.605C>T	c.(604-606)tCc>tTc	p.S202F	LCA5_ENST00000467898.2_Missense_Mutation_p.S202F|LCA5_ENST00000369846.4_Missense_Mutation_p.S202F	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	202					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TTTCTGTAAGGAAAATTTTGT	0.378000													42	44					0	0	1	0	0
C6orf15	29113	broad.mit.edu	37	6	31079453	31079453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31079453C>T	ENST00000259870.3	-	2	686	c.683G>A	c.(682-684)gGa>gAa	p.G228E		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	228	Gly-rich.									endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						GGGCCTCGTTCCCCAACCAGT	0.592000													8	65					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8976750	8976750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8976750G>A	ENST00000397910.4	-	73	42519	c.42316C>T	c.(42316-42318)Ctt>Ttt	p.L14106F	MUC16_ENST00000596956.1_5'UTR|MUC16_ENST00000380951.5_Missense_Mutation_p.L747F	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14137	SEA 14.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGTGCTGAAGGACCCCCTCG	0.552000													11	33					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16822601	16822601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:16822601C>T	ENST00000355661.3	-	17	2339	c.2329G>A	c.(2329-2331)Gaa>Aaa	p.E777K	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.E777K|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.E777K			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	777					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TTCAGGTATTCGTTCCAAGCA	0.498000													48	174					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179599149	179599149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179599149G>A	ENST00000589042.1	-	52	15626	c.15402C>T	c.(15400-15402)atC>atT	p.I5134I	TTN_ENST00000342992.6_Silent_p.I3890I|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.I4817I|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4817	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAACGAAAAGATCTCCAGAC	0.383000													52	162					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157931073	157931073	+	Nonsense_Mutation	SNP	G	G	A	rs142009346	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157931073G>A	ENST00000389413.3	-	7	1148	c.1045C>T	c.(1045-1047)Cga>Tga	p.R349*	PTPRN2_ENST00000389416.4_Nonsense_Mutation_p.R332*|PTPRN2_ENST00000404321.2_Nonsense_Mutation_p.R372*|PTPRN2_ENST00000389418.4_Nonsense_Mutation_p.R349*|PTPRN2_ENST00000409483.1_Nonsense_Mutation_p.R311*	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	349						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGGCTGCCTCGAGCTACTCCA	0.672000													33	80					0	0	1	0	0
TUBBP1	92755	broad.mit.edu	37	8	30210064	30210064	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30210064G>A	ENST00000518096.1	+	0	676																											CACCGTGATCGAGTCCTACAA	0.498000													21	40					0	0	1	0	0
LIMS1	3987	broad.mit.edu	37	2	109276206	109276206	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:109276206G>T	ENST00000393310.1	+	2	309	c.142G>T	c.(142-144)Gga>Tga	p.G48*	LIMS1_ENST00000410093.1_Nonsense_Mutation_p.G52*|LIMS1_ENST00000393314.2_Nonsense_Mutation_p.G110*|LIMS1_ENST00000544547.1_Nonsense_Mutation_p.G60*|LIMS1_ENST00000338045.3_Nonsense_Mutation_p.G48*|LIMS1_ENST00000542845.1_Nonsense_Mutation_p.G110*|LIMS1_ENST00000332345.6_Nonsense_Mutation_p.G48*|LIMS1_ENST00000462817.1_3'UTR|LIMS1_ENST00000409441.1_Nonsense_Mutation_p.G85*	NM_001193488.1	NP_001180417.1	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	48	LIM zinc-binding 1.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	10						GTTCCCAGAAGGACTCTTCTA	0.577000													23	92					5.35356e-11	5.37587e-11	1	1	0
PTPRH	5794	broad.mit.edu	37	19	55699491	55699491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55699491C>T	ENST00000376350.3	-	13	2452	c.2430G>A	c.(2428-2430)agG>agA	p.R810R	PTPRH_ENST00000263434.5_Silent_p.R632R	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	810					apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TCTCATTCTTCCTGACGTGGT	0.572000													55	112					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256043	140256043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140256043C>T	ENST00000398631.2	+	1	986	c.986C>T	c.(985-987)tCc>tTc	p.S329F	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGATTCCTTCCATGGCAGGT	0.433000													27	67					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106740156	106740156	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:106740156C>T	ENST00000299045.3	+	10	1582	c.1408C>T	c.(1408-1410)Cag>Tag	p.Q470*		NM_152772.1	NP_689985.1	Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	470										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						AGCTGTCATTCAGCAGGAGCT	0.428000													10	33					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73477983	73477983	+	Missense_Mutation	SNP	G	G	A	rs34852121		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73477983G>A	ENST00000252034.7	+	29	2350	c.1951G>A	c.(1951-1953)Gga>Aga	p.G651R	ELN_ENST00000380553.4_Missense_Mutation_p.G515R|ELN_ENST00000380562.4_Missense_Mutation_p.G657R|ELN_ENST00000358929.4_Missense_Mutation_p.G719R|ELN_ENST00000414324.1_Missense_Mutation_p.G627R|ELN_ENST00000320399.6_Missense_Mutation_p.G684R|ELN_ENST00000429192.1_Missense_Mutation_p.G637R|ELN_ENST00000380584.4_Missense_Mutation_p.G603R|ELN_ENST00000445912.1_Missense_Mutation_p.G651R|ELN_ENST00000458204.1_Missense_Mutation_p.G641R|ELN_ENST00000357036.5_Missense_Mutation_p.G656R|ELN_ENST00000380576.5_Missense_Mutation_p.G632R|ELN_ENST00000320492.7_Missense_Mutation_p.G570R|ELN_ENST00000380575.4_Missense_Mutation_p.G622R	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	713	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CGGAGGACTCGGAGTCGGAGG	0.587000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						18	109					0	0	1	0	0
CPN2	1370	broad.mit.edu	37	3	194062985	194062985	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:194062985G>A	ENST00000323830.3	-	2	536	c.447C>T	c.(445-447)tcC>tcT	p.S149S	CPN2_ENST00000429275.1_Silent_p.S149S	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	149					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GCAGGTGGAGGGACTCCAGGG	0.627000													15	30					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27375502	27375502	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27375502C>T	ENST00000376087.4	-	5	840	c.675G>A	c.(673-675)agG>agA	p.R225R	ANKRD26_ENST00000436985.2_Silent_p.R225R	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	225						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						GTTTAGGTATCCTTTCTTCTT	0.264000													27	83					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136600940	136600940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136600940C>T	ENST00000531224.1	-	3	317	c.65G>A	c.(64-66)cGa>cAa	p.R22Q	BCLAF1_ENST00000392348.2_Missense_Mutation_p.R22Q|BCLAF1_ENST00000530767.1_Missense_Mutation_p.R22Q|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R22Q|BCLAF1_ENST00000527536.1_Missense_Mutation_p.R22Q|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R22Q	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	22					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGATCTTGATCGAGAACTAGA	0.323000													4	56					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85478726	85478726	+	Missense_Mutation	SNP	G	G	A	rs147369428	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85478726G>A	ENST00000394573.1	+	15	1760	c.1558G>A	c.(1558-1560)Ggc>Agc	p.G520S	SLC28A1_ENST00000286749.3_Missense_Mutation_p.G520S|SLC28A1_ENST00000538177.1_Intron|SLC28A1_ENST00000537624.1_Missense_Mutation_p.G520S|SLC28A1_ENST00000537216.1_Missense_Mutation_p.G520S	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	520					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGAGTGGGTCGGCGACAGGAA	0.622000													24	212					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081516	152081516	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152081516G>A	ENST00000368804.1	-	2	4176	c.4177C>T	c.(4177-4179)Ctt>Ttt	p.L1393F		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1393	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTCCTTAAGGAATTTTCTC	0.587000													20	166					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33895456	33895456	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33895456C>T	ENST00000389232.4	+	18	2125	c.2055C>T	c.(2053-2055)gcC>gcT	p.A685A	RYR3_ENST00000415757.3_Silent_p.A685A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	685	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGGCTGGGCCTCTTCTTCAG	0.567000													61	183					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41963935	41963935	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:41963935C>T	ENST00000454645.1	-	0	660					NR_003670.1																						TCCTGATTTCCATGATATCTG	0.408000													14	135					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228560541	228560541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228560541C>T	ENST00000570156.2	+	105	25007	c.24933C>T	c.(24931-24933)ccC>ccT	p.P8311P	OBSCN_ENST00000366707.4_Silent_p.P4988P|OBSCN_ENST00000422127.1_Silent_p.P7354P	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7354					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCACGTGGCCCTGGCCAGGTG	0.657000													9	9					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767661	105767661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:105767661G>A	ENST00000374798.3	+	5	818	c.748G>A	c.(748-750)Gat>Aat	p.D250N	CYLC2_ENST00000487798.1_Missense_Mutation_p.D250N	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	250	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				TGGAAAAAAAGATGCAAACAA	0.368000													10	48					0	0	1	0	0
ZC3H18	124245	broad.mit.edu	37	16	88695234	88695234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:88695234C>T	ENST00000301011.5	+	16	2738	c.2538C>T	c.(2536-2538)gcC>gcT	p.A846A	ZC3H18_ENST00000452588.2_Silent_p.A870A	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	846						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CTCCTCCAGCCAAGCGGCCCA	0.642000													31	111					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956481	18956481	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18956481C>T	ENST00000302797.3	-	0	75				MRGPRX1_ENST00000526914.1_Intron	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1						acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						gaataagtcacctatcaaaag	0.473000													5	16					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96315551	96315551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:96315551C>T	ENST00000231368.5	+	2	1421	c.729C>T	c.(727-729)atC>atT	p.I243I	LNPEP_ENST00000395770.3_Silent_p.I229I	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	243					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		ATGGACAGATCGCCATTGTTG	0.408000													5	78					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28895627	28895627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28895627C>T	ENST00000282397.4	-	23	3398	c.3147G>A	c.(3145-3147)aaG>aaA	p.K1049K	FLT1_ENST00000540678.1_Silent_p.K267K|FLT1_ENST00000543394.1_Silent_p.K72K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1049	Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AATCGGGGTTCTTATAAATAT	0.383000													35	76					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68606139	68606139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68606139C>T	ENST00000423218.2	-	23	2955	c.2860G>A	c.(2860-2862)Gag>Aag	p.E954K	ITGA11_ENST00000315757.7_Missense_Mutation_p.E954K			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	954					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	ACGTCAGCCTCGTATTTGAGG	0.637000													7	32					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55202097	55202097	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:55202097G>A	ENST00000396834.1	+	11	1672	c.1176G>A	c.(1174-1176)acG>acA	p.T392T	IL31RA_ENST00000297015.3_Silent_p.T269T|IL31RA_ENST00000396836.2_Silent_p.T411T|IL31RA_ENST00000354961.4_Silent_p.T392T|IL31RA_ENST00000447346.2_Silent_p.T411T|IL31RA_ENST00000359040.5_Silent_p.T411T|IL31RA_ENST00000490985.1_Silent_p.T269T	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	379	Fibronectin type-III 4.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				CTCAGGCCACGAACTGGACGA	0.498000													19	38					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7582885	7582885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7582885G>A	ENST00000379802.3	+	24	5731	c.5390G>A	c.(5389-5391)aGg>aAg	p.R1797K	DSP_ENST00000418664.2_Missense_Mutation_p.R1198K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1797	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCATCTAATAGGATTCAGGAA	0.373000													28	75					0	0	1	0	0
CHRNA3	1136	broad.mit.edu	37	15	78888958	78888958	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78888958C>T	ENST00000326828.5	-	6	1890	c.1506G>A	c.(1504-1506)agG>agA	p.R502R	CHRNA3_ENST00000348639.3_Intron	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	502					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						ATGCATCTTCCCTGGCCATCA	0.493000													21	71					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594170	64594170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64594170C>T	ENST00000342711.5	-	35	4485	c.4486G>A	c.(4486-4488)Gaa>Aaa	p.E1496K		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1496					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						CCGAGGCCTTCGCTGCCCATG	0.677000													4	2					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028738	37028738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37028738C>T	ENST00000358047.3	+	1	2307	c.2255C>T	c.(2254-2256)cCa>cTa	p.P752L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	752								p.P752Q(2)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGTCTCCGCCCAGAGCCTCTT	0.622000													25	38					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70992650	70992650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70992650C>T	ENST00000354624.5	+	3	490	c.357C>T	c.(355-357)atC>atT	p.I119I	HKDC1_ENST00000395086.2_Silent_p.I119I	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	119					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						ATGAAATCATCCGCGGGAACG	0.587000													39	134					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127961109	127961109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:127961109C>T	ENST00000335247.7	-	2	147	c.17G>A	c.(16-18)aGa>aAa	p.R6K	CYP27C1_ENST00000409327.1_Missense_Mutation_p.R6K	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	6						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		AATTCTTTGTCTCAATACGCT	0.398000													24	187					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15234791	15234791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:15234791G>A	ENST00000395930.1	-	3	298	c.112C>T	c.(112-114)Ccc>Tcc	p.P38S	TEKT3_ENST00000338696.2_Missense_Mutation_p.P38S	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	38					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TTGGAGTGGGGAAAGCGGTCC	0.537000													18	33					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287591	16287591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:16287591C>T	ENST00000343518.6	-	1	346	c.295G>A	c.(295-297)Ggc>Agc	p.G99S		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	99								p.G99C(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CACCACTTGCCCATCTTGCTC	0.602000													88	396					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85525463	85525463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85525463C>T	ENST00000295887.5	+	2	608	c.185C>T	c.(184-186)cCa>cTa	p.P62L		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	62					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		CCGGAAATTCCACCATCCTCA	0.343000													38	76					0	0	1	0	0
FLAD1	80308	broad.mit.edu	37	1	154960885	154960885	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154960885C>T	ENST00000368433.1	+	2	1020	c.677C>T	c.(676-678)tCt>tTt	p.S226F	FLAD1_ENST00000292180.3_Missense_Mutation_p.S226F|FLAD1_ENST00000368432.1_Missense_Mutation_p.S129F|FLAD1_ENST00000368431.3_Missense_Mutation_p.S127F|FLAD1_ENST00000487371.1_3'UTR|FLAD1_ENST00000405236.2_Missense_Mutation_p.S127F|FLAD1_ENST00000295530.2_5'UTR|FLAD1_ENST00000315144.10_Missense_Mutation_p.S129F			Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	226					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTGCCCTCCTCTGCCCGCCTG	0.567000													29	54					0	0	1	0	0
PRPF4	9128	broad.mit.edu	37	9	116053831	116053831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116053831C>T	ENST00000374199.4	+	14	1858	c.1457C>T	c.(1456-1458)aCt>aTt	p.T486I	PRPF4_ENST00000374198.4_Missense_Mutation_p.T487I			O43172	PRP4_HUMAN	pre-mRNA processing factor 4	487						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	23						CCGCTGAAGACTCTGGCTGGC	0.522000													10	103					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49459684	49459684	+	Missense_Mutation	SNP	C	C	T	rs143814415		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49459684C>T	ENST00000374201.3	-	2	378	c.76G>A	c.(76-78)Gaa>Aaa	p.E26K	FRMPD2_ENST00000407470.4_Missense_Mutation_p.E17K|FRMPD2_ENST00000305531.3_Missense_Mutation_p.E24K	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	26	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GACAGAGCTTCACCCCTGACC	0.572000													23	53					0	0	1	0	0
CRYAA	1409	broad.mit.edu	37	21	44590729	44590729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:44590729G>A	ENST00000291554.2	+	2	384	c.292G>A	c.(292-294)Gga>Aga	p.G98R	CRYAA_ENST00000482775.1_3'UTR|CRYAA_ENST00000398132.1_Missense_Mutation_p.G61R|CRYAA_ENST00000398133.1_Missense_Mutation_p.G78R	NM_000394.2	NP_000385.1	P02489	CRYAA_HUMAN	crystallin, alpha A	98					anti-apoptosis|negative regulation of intracellular transport|protein homooligomerization|response to heat|visual perception	cytoplasm|nucleus	structural constituent of eye lens|unfolded protein binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	11						GGAGATCCACGGAAAGCACAA	0.642000													13	53					0	0	1	0	0
SBK1	388228	broad.mit.edu	37	16	28331753	28331753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28331753C>T	ENST00000341901.4	+	4	1575	c.786C>T	c.(784-786)ttC>ttT	p.F262F		NM_001024401.2	NP_001019572.1	Q52WX2	SBK1_HUMAN	SH3 domain binding kinase 1	262	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			kidney(1)|lung(3)|ovary(1)	5						CCGACGCCTTCTTCGAGGAGT	0.716000													13	27					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18657714	18657714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18657714G>A	ENST00000380548.4	+	8	1251	c.912G>A	c.(910-912)acG>acA	p.T304T	ADAMTSL1_ENST00000327883.7_Silent_p.T304T|ADAMTSL1_ENST00000276935.6_Silent_p.T304T|ADAMTSL1_ENST00000380566.4_Silent_p.T304T	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	304						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GGAGGGAGACGGATTTCTTTC	0.463000													7	36					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086734	92086734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92086734C>T	ENST00000298047.6	+	1	1473	c.1456C>T	c.(1456-1458)Cca>Tca	p.P486S	FAT3_ENST00000541502.1_Missense_Mutation_p.P486S|FAT3_ENST00000409404.2_Missense_Mutation_p.P486S|FAT3_ENST00000525166.1_Missense_Mutation_p.P336S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	486	Cadherin 5.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAAAGTGTCCCAGTGGGAAC	0.413000										TCGA Ovarian(4;0.039)			6	52					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28273976	28273976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28273976G>A	ENST00000305242.5	-	4	639	c.547C>T	c.(547-549)Ctc>Ttc	p.L183F	ARMC4_ENST00000239715.3_Missense_Mutation_p.L40F	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	183							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GAATGATTGAGGAGGTGCAGA	0.373000													5	22					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264286	155264286	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155264286C>T	ENST00000392414.3	-	6	972	c.859G>A	c.(859-861)Gaa>Aaa	p.E287K	PKLR_ENST00000342741.4_Missense_Mutation_p.E318K	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	318			F -> V (in PKRD).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	TTCACGCCTTCGTGGTTCTCA	0.582000													22	62					0	0	1	0	0
PMVK	10654	broad.mit.edu	37	1	154897656	154897656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154897656G>A	ENST00000368467.3	-	5	833	c.528C>T	c.(526-528)cgC>cgT	p.R176R		NM_006556.3	NP_006547.1	Q15126	PMVK_HUMAN	phosphomevalonate kinase	176					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCTCCTCCAGGCGCTGTTCAA	0.547000													54	236					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921522	24921522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24921522G>A	ENST00000329468.2	+	1	982	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GGTGCAGATCGAAGGGGAGGA	0.617000													15	33					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75210016	75210016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:75210016C>T	ENST00000413679.2	+	17	2362	c.2059C>T	c.(2059-2061)Ctg>Ttg	p.L687L	SEC14L1_ENST00000436233.4_Silent_p.L687L|SEC14L1_ENST00000430767.4_Silent_p.L687L|SEC14L1_ENST00000443798.4_Silent_p.L687L|SEC14L1_ENST00000591437.1_Silent_p.L653L|SEC14L1_ENST00000431431.2_Silent_p.L653L|SEC14L1_ENST00000392476.2_Silent_p.L687L|SEC14L1_ENST00000585618.1_Silent_p.L687L	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	687					transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						CATGACGAGCCTGGAGTCCAG	0.667000													13	148					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778337	31778337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31778337C>T	ENST00000375654.4	-	2	1602	c.1413G>A	c.(1411-1413)agG>agA	p.R471R	HSPA1L_ENST00000417199.3_Silent_p.R471R	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	471					response to unfolded protein		ATP binding	p.R471R(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						GAGGAACTCCCCTGGGTGCTG	0.557000													43	104					0	0	1	0	0
ZDHHC22	283576	broad.mit.edu	37	14	77600103	77600103	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77600103C>T	ENST00000319374.4	-	3	917	c.715G>A	c.(715-717)Gga>Aga	p.G239R	RP11-463C8.4_ENST00000557752.1_Intron	NM_174976.2	NP_777636.2	Q8N966	ZDH22_HUMAN	zinc finger, DHHC-type containing 22	239						integral to membrane	acyltransferase activity|zinc ion binding			kidney(1)|lung(1)|urinary_tract(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		CACCTCTTTCCGAAGACCTCT	0.602000													18	34					0	0	1	0	0
CIB3	117286	broad.mit.edu	37	19	16275561	16275561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16275561C>T	ENST00000269878.4	-	5	559	c.510G>A	c.(508-510)caG>caA	p.Q170Q	CIB3_ENST00000541493.1_5'UTR|CIB3_ENST00000379859.3_Silent_p.Q121Q	NM_054113.2	NP_473454.1	Q96Q77	CIB3_HUMAN	calcium and integrin binding family member 3	170	EF-hand 3.						calcium ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16						GGATCATGTTCTGGAAATCTT	0.587000													10	53					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10470832	10470832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10470832G>A	ENST00000382483.3	-	4	999	c.776C>T	c.(775-777)cCg>cTg	p.P259L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	259					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GATCACACTCGGCTTGGTCTT	0.602000													29	59					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158725176	158725176	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158725176A>T	ENST00000368144.2	+	1	667	c.571A>T	c.(571-573)Att>Ttt	p.I191F		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					GATTGCATGGATTTCCACCTT	0.483000													35	70					0	0	1	0	0
ZNF18	7566	broad.mit.edu	37	17	11881712	11881712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11881712G>A	ENST00000322748.3	-	9	1816	c.1212C>T	c.(1210-1212)gcC>gcT	p.A404A	ZNF18_ENST00000454073.3_Silent_p.A403A|ZNF18_ENST00000580306.1_Silent_p.A404A|ZNF18_ENST00000580613.1_Intron	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	404					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		GGAGCTTCTGGGCCATGGGGG	0.507000													6	64					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103109210	103109210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:103109210G>A	ENST00000374902.4	-	3	835	c.659C>T	c.(658-660)tCt>tTt	p.S220F	TEX10_ENST00000535814.1_Missense_Mutation_p.S223F|TEX10_ENST00000537512.1_Missense_Mutation_p.S155F	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	220						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CCATTGCTGAGAAGTGAGTCT	0.438000													16	79					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050262	42050262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42050262G>A	ENST00000372584.1	-	3	1221	c.207C>T	c.(205-207)ggC>ggT	p.G69G	HIVEP3_ENST00000247584.5_Silent_p.G69G|HIVEP3_ENST00000372583.1_Silent_p.G69G|HIVEP3_ENST00000429157.2_Silent_p.G69G	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	69					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding	p.G69G(1)		NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TCTCCTGAGAGCCTTCCCTAA	0.637000													70	162					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166896371	166896371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:166896371C>T	ENST00000271417.3	-	7	982	c.927G>A	c.(925-927)atG>atA	p.M309I	ILDR2_ENST00000528703.1_Missense_Mutation_p.M250I|ILDR2_ENST00000469934.2_Missense_Mutation_p.M309I|ILDR2_ENST00000529071.1_Missense_Mutation_p.M290I|ILDR2_ENST00000525740.1_Missense_Mutation_p.M182I|ILDR2_ENST00000526687.1_Missense_Mutation_p.M201I|ILDR2_ENST00000529387.1_Intron	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	309						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						ACAGGACCTTCATGGAGTCTC	0.463000													62	107					0	0	1	0	0
MATN3	4148	broad.mit.edu	37	2	20205896	20205896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:20205896G>A	ENST00000407540.3	-	2	461	c.399C>T	c.(397-399)atC>atT	p.I133I	MATN3_ENST00000421259.2_Silent_p.I133I	NM_002381.4	NP_002372.1	O15232	MATN3_HUMAN	matrilin 3	133	VWFA.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTGGAACTCGATCTTCACAG	0.547000													15	25					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131831414	131831414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131831414C>T	ENST00000359827.3	-	28	5872	c.4910G>A	c.(4909-4911)cGg>cAg	p.R1637Q	PLXNA4_ENST00000321063.4_Missense_Mutation_p.R1637Q			Q9HCM2	PLXA4_HUMAN	plexin A4	1637						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CATAGGTGTCCGTGAGCGGAG	0.602000													62	180					0	0	1	0	0
HGFAC	3083	broad.mit.edu	37	4	3445789	3445789	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3445789G>A	ENST00000382774.3	+	5	614	c.499G>A	c.(499-501)Ggc>Agc	p.G167S	HGFAC_ENST00000511533.1_Missense_Mutation_p.G167S	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	167	EGF-like 1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CTGTGCCTCCGGCCCCTGCCT	0.662000													27	50					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140011718	140011718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140011718G>A	ENST00000302014.6	-	2	1480	c.851C>T	c.(850-852)tCg>tTg	p.S284L	CD14_ENST00000401743.2_Missense_Mutation_p.S284L	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	284					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCAGCGAACGACAGATTGAG	0.617000													20	65					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30680738	30680738	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30680738G>A	ENST00000376406.3	-	5	1628	c.981C>T	c.(979-981)atC>atT	p.I327I	MDC1_ENST00000376405.2_Silent_p.I327I|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	327	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TGTCGCTGTCGATGAAGCCAA	0.532000								Other conserved DNA damage response genes					18	169					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151835361	151835361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:151835361C>T	ENST00000535741.1	-	9	1620	c.1147G>A	c.(1147-1149)Ggc>Agc	p.G383S	LRBA_ENST00000510413.1_Missense_Mutation_p.G383S|LRBA_ENST00000357115.3_Missense_Mutation_p.G383S|LRBA_ENST00000507224.1_Missense_Mutation_p.G383S			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	383						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TATCCCAGGCCCAACTGATAA	0.393000													36	156					0	0	1	0	0
LCE3D	84648	broad.mit.edu	37	1	152552347	152552347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152552347G>A	ENST00000368787.3	-	2	122	c.66C>T	c.(64-66)ccC>ccT	p.P22P		NM_032563.1	NP_115952.1	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	22					keratinization					breast(1)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|stomach(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GGCTCTTTGGGGGACACTTGG	0.607000													24	151					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189587118	189587118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189587118C>T	ENST00000264731.3	+	9	1224	c.1135C>T	c.(1135-1137)Cgt>Tgt	p.R379C	TP63_ENST00000392460.3_Missense_Mutation_p.R379C|TP63_ENST00000449992.1_Missense_Mutation_p.R200C|TP63_ENST00000392463.2_Missense_Mutation_p.R285C|TP63_ENST00000440651.2_Missense_Mutation_p.R375C|TP63_ENST00000320472.5_Missense_Mutation_p.R379C|TP63_ENST00000392461.3_Missense_Mutation_p.R285C|TP63_ENST00000382063.4_Missense_Mutation_p.R294C|TP63_ENST00000456148.1_Missense_Mutation_p.R281C|TP63_ENST00000437221.1_Missense_Mutation_p.R285C|TP63_ENST00000354600.5_Missense_Mutation_p.R285C|TP63_ENST00000418709.2_Missense_Mutation_p.R379C	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	379	Interaction with HIPK2.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R379C(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCAGCGTTTCGTCAGAACAC	0.363000										HNSCC(45;0.13)			13	53					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38860616	38860616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38860616C>T	ENST00000409235.3	+	27	3140	c.3025C>T	c.(3025-3027)Ctc>Ttc	p.L1009F	CATSPERG_ENST00000410018.1_Missense_Mutation_p.L969F|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	1009					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						TTGCAGGTGGCTCTGTCTGGA	0.512000													68	154					0	0	1	0	0
TMEM19	55266	broad.mit.edu	37	12	72092798	72092798	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72092798C>T	ENST00000266673.5	+	5	1350	c.756C>T	c.(754-756)gcC>gcT	p.A252A	TMEM19_ENST00000549735.1_Silent_p.A252A	NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	252						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		ACATTTCTGCCCCGCAGTGGC	0.453000													46	78					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175087870	175087870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175087870G>A	ENST00000239462.4	+	11	2673	c.2560G>A	c.(2560-2562)Ggc>Agc	p.G854S		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	854	Fibronectin type-III 7.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGTCCTGACGGGCCTGAGGCC	0.607000													28	91					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66802194	66802194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66802194G>A	ENST00000393946.2	+	6	1275	c.113G>A	c.(112-114)aGc>aAc	p.S38N	SYT12_ENST00000527043.1_Missense_Mutation_p.S38N|SYT12_ENST00000526281.1_Intron|SYT12_ENST00000525457.1_Missense_Mutation_p.S38N			Q8IV01	SYT12_HUMAN	synaptotagmin XII	38						cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						GCAGCTGTGAGCCTGTGGAAG	0.632000													22	61					0	0	1	0	0
ETV5	2119	broad.mit.edu	37	3	185766484	185766484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185766484G>A	ENST00000306376.5	-	13	1723	c.1477C>T	c.(1477-1479)Ctc>Ttc	p.L493F	ETV5_ENST00000434744.1_Missense_Mutation_p.L493F|ETV5_ENST00000537818.1_Missense_Mutation_p.L535F|ETV5_ENST00000480706.1_5'UTR	NM_004454.2	NP_004445.1	P41161	ETV5_HUMAN	ets variant 5	493					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|cervix(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	28	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			ATGTCCAGGAGGTAAGCGGGG	0.602000			T	"""TMPRSS2, SCL45A3"""	Prostate								22	48					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52827873	52827873	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52827873G>A	ENST00000252245.5	-	1	436	c.216C>T	c.(214-216)tcC>tcT	p.S72S		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	72	Gly-rich.|Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		ACCCATTGATGGAGACCCGCT	0.622000													34	67					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631943	32631943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32631943G>A	ENST00000242310.4	-	1	3724	c.3635C>T	c.(3634-3636)gCc>gTc	p.A1212V		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1212					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GCGCACATAGGCATCAATGAC	0.448000													61	94					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21548335	21548335	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21548335C>T	ENST00000415912.2	-	18	2118	c.1992_splice	c.e18-1	p.A665_splice	ECE1_ENST00000374893.6_Splice_Site_p.A681_splice|ECE1_ENST00000436918.2_Intron|ECE1_ENST00000264205.6_Splice_Site_p.A678_splice|ECE1_ENST00000357071.4_Splice_Site_p.A669_splice	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	681					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TTCTGGTAAGCCTGGGAGGAG	0.597000													54	100					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803905	23803905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:23803905C>T	ENST00000264867.2	-	11	2202	c.2083G>A	c.(2083-2085)Gac>Aac	p.D695N	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	695	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TCAAAACGGTCCCTCAGTTCT	0.458000													13	119					0	0	1	0	0
SLC45A3	85414	broad.mit.edu	37	1	205632659	205632659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205632659G>A	ENST00000367145.3	-	3	555	c.260C>T	c.(259-261)cCc>cTc	p.P87L		NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	87					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			CCAGATGAAGGGCCGGCGGCG	0.662000			T	"""ETV1, ETV5, ELK4, ERG"""	prostate								19	44					0	0	1	0	0
LRRC15	131578	broad.mit.edu	37	3	194080213	194080213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:194080213G>A	ENST00000347624.3	-	2	1645	c.1560C>T	c.(1558-1560)acC>acT	p.T520T	LRRC15_ENST00000439944.2_Silent_p.T526T|LRRC15_ENST00000428839.1_Silent_p.T526T	NM_130830.4	NP_570843.2	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15	520						integral to membrane				biliary_tract(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(20)|ovary(4)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TGACCTGAATGGTAGTCAGAT	0.572000													9	31					0	0	1	0	0
TMCC3	57458	broad.mit.edu	37	12	94975597	94975597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:94975597C>T	ENST00000261226.4	-	2	927	c.796G>A	c.(796-798)Gac>Aac	p.D266N	TMCC3_ENST00000551457.1_Missense_Mutation_p.D235N	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	266						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						CCGTTACTGTCGGCCGAGCCT	0.597000													32	98					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39613254	39613254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39613254G>A	ENST00000265708.4	-	16	1893	c.1790C>T	c.(1789-1791)tCa>tTa	p.S597L	ADAM2_ENST00000347580.4_Missense_Mutation_p.S578L|ADAM2_ENST00000521880.1_Intron|ADAM2_ENST00000379853.2_Missense_Mutation_p.S441L	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	597	Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TACCTTATTTGAACCACAAGA	0.398000													12	28					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907650	12907650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12907650C>T	ENST00000317869.6	-	2	718	c.493G>A	c.(493-495)Gga>Aga	p.G165R		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						CCCCGCTTTCCACTCTTAGAA	0.488000													92	478					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541302	40541302	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40541302A>G	ENST00000434248.1	-	5	1529	c.1464T>C	c.(1462-1464)ctT>ctC	p.L488L	ZNF780B_ENST00000221355.6_Silent_p.L340L	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGTCGAGCAAGCTGTGTCA	0.403000													32	103					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57967220	57967220	+	Missense_Mutation	SNP	G	G	A	rs146505887	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57967220G>A	ENST00000574161.1	+	12	1377	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	GCOM1_ENST00000380560.2_Missense_Mutation_p.E351K|GCOM1_ENST00000380569.2_Missense_Mutation_p.E420K|GCOM1_ENST00000572390.1_Missense_Mutation_p.E392K|MYZAP_ENST00000267853.5_Missense_Mutation_p.E420K|GCOM1_ENST00000587652.1_Missense_Mutation_p.E420K|GCOM1_ENST00000396180.1_Missense_Mutation_p.E389K|GCOM1_ENST00000380561.2_Missense_Mutation_p.E361K|MYZAP_ENST00000380565.4_Missense_Mutation_p.E392K|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380568.3_Missense_Mutation_p.E420K	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		420					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GGCCAAGACTGAAGTGGAAAC	0.378000													7	67					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158139206	158139206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:158139206G>A	ENST00000313708.6	-	14	1787	c.1505C>T	c.(1504-1506)tCc>tTc	p.S502F	EBF1_ENST00000517373.1_Intron|EBF1_ENST00000380654.4_Missense_Mutation_p.S471F|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	502	Pro/Ser/Thr-rich.				multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAAGGTGGGGGAGCCGCCCAA	0.567000			T	HMGA2	lipoma								4	27					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45708297	45708297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45708297G>A	ENST00000291582.5	+	5	735	c.608G>A	c.(607-609)cGa>cAa	p.R203Q		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	203	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		CCGGGAGCCCGAGGGGCCGTG	0.632000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				33	59					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95718849	95718849	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95718849C>T	ENST00000480546.1	-	0	2448					NR_002319.2																						ATCTTCTCTTCCTCAGTCATA	0.532000													18	38					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44624560	44624560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:44624560G>A	ENST00000332990.5	-	6	730	c.714C>T	c.(712-714)atC>atT	p.I238I		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	238						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						ACCAGCCAATGATGACCAGGG	0.453000													13	37					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398577	89398577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89398577G>A	ENST00000439576.2	+	12	3135	c.2761G>A	c.(2761-2763)Ggg>Agg	p.G921R	ACAN_ENST00000559004.1_Missense_Mutation_p.G921R|ACAN_ENST00000561243.1_Missense_Mutation_p.G921R|ACAN_ENST00000352105.7_Missense_Mutation_p.G921R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	921					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			ACTACCCTCAGGGGATGAAGA	0.587000													29	33					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52732463	52732463	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:52732463G>C	ENST00000287727.3	+	6	2587	c.2415G>C	c.(2413-2415)gtG>gtC	p.V805V	ZFYVE9_ENST00000357206.2_Intron|ZFYVE9_ENST00000371591.1_Silent_p.V805V	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	805	SBD.				endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						CTCCCACTGTGATGGTACCTG	0.507000													24	57					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226490	23226490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23226490C>T	ENST00000300061.2	+	13	1793	c.1650C>T	c.(1648-1650)atC>atT	p.I550I		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	550					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TCGAGATCATCGAGGTCTTCT	0.557000													15	64					0	0	1	0	0
SLC25A37	51312	broad.mit.edu	37	8	23429132	23429132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:23429132C>T	ENST00000519973.1	+	4	979	c.781C>T	c.(781-783)Ctt>Ttt	p.L261F		NM_016612.2	NP_057696.2	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 37	261					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				NS(1)|endometrium(3)|large_intestine(2)|lung(8)|urinary_tract(1)	15		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		CTGTAAGACCCTTCTGAACAC	0.677000													10	22					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	92027859	92027859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92027859C>T	ENST00000265742.3	+	20	3242	c.2866C>T	c.(2866-2868)Cct>Tct	p.P956S		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	956							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATCTAGTGATCCTGACTCAGC	0.493000													46	97					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561352	9561352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9561352C>T	ENST00000378429.3	-	5	976	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	PAK7_ENST00000378423.1_Missense_Mutation_p.E144K|PAK7_ENST00000353224.5_Missense_Mutation_p.E144K	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	144	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity	p.E144K(1)		NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CTGTACTTTTCGGTCGTGTAG	0.512000													41	190					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975411	20975411	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20975411G>A	ENST00000261383.3	-	53	9794	c.9795C>T	c.(9793-9795)tcC>tcT	p.S3265S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3265	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCACTTTGGAGGAGGACAGAA	0.468000													43	135					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32065044	32065044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32065044G>A	ENST00000375244.3	-	3	787	c.586C>T	c.(586-588)Cgc>Tgc	p.R196C	TNXB_ENST00000479795.1_Missense_Mutation_p.R196C|TNXB_ENST00000375247.2_Missense_Mutation_p.R196C			P22105	TENX_HUMAN	tenascin XB	196	EGF-like 2.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CGGACACAGCGACCCTGATCA	0.667000													5	15					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36166626	36166626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36166626C>T	ENST00000303965.4	-	11	2572	c.2083G>A	c.(2083-2085)Gaa>Aaa	p.E695K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	695	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTGTTGGATTCATTGAACCAA	0.433000													6	79					0	0	1	0	0
C7orf26	79034	broad.mit.edu	37	7	6641744	6641744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:6641744C>T	ENST00000344417.5	+	5	1388	c.1121C>T	c.(1120-1122)aCc>aTc	p.T374I	C7orf26_ENST00000359073.5_Missense_Mutation_p.T277I|C7orf26_ENST00000472693.1_3'UTR	NM_024067.2	NP_076972.2	Q96N11	CG026_HUMAN	chromosome 7 open reading frame 26	374										endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	11		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		GACCTGAGAACCTTGTGCTCC	0.502000											OREG0017863	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	67					0	0	1	0	0
TTLL11	158135	broad.mit.edu	37	9	124752002	124752002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:124752002G>A	ENST00000321582.5	-	4	1198	c.1011C>T	c.(1009-1011)atC>atT	p.I337I	TTLL11_ENST00000474723.1_5'UTR|TTLL11_ENST00000373776.3_Silent_p.I337I	NM_001139442.1	NP_001132914.1	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	337	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity	p.I337I(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						CAGGTTTCACGATAAAAGTGG	0.532000													44	172					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123163094	123163094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123163094C>T	ENST00000349780.4	-	35	5556	c.5377G>A	c.(5377-5379)Gcc>Acc	p.A1793T	CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.A1752T|CDK5RAP2_ENST00000480467.1_5'UTR|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.A1761T|CDK5RAP2_ENST00000360190.4_Missense_Mutation_p.A1714T	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1793	Interaction with PCNT and AKAP9.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						CGCCTGTAGGCCTCTTCCAGG	0.587000													15	57					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42729691	42729691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42729691C>T	ENST00000287777.4	+	2	1310	c.1210C>T	c.(1210-1212)Ctc>Ttc	p.L404F		NM_152393.2	NP_689606.2			kelch-like family member 40																		GCCCCGCTGCCTCTTTGGCCT	0.642000													21	55					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249706	52249706	+	Missense_Mutation	SNP	G	G	A	rs146075164		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52249706G>A	ENST00000595042.1	-	3	683	c.542C>T	c.(541-543)tCg>tTg	p.S181L	FPR1_ENST00000304748.4_Missense_Mutation_p.S181L	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	181					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity	p.S181L(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GGTCCAGGGCGAAAAGTTAAA	0.527000													29	75					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158272456	158272456	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158272456C>A	ENST00000264192.3	-	8	934	c.813G>T	c.(811-813)agG>agT	p.R271S	CYTIP_ENST00000540637.1_Missense_Mutation_p.R165S	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	271	Ser-rich.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						TGAAGGCACCCCTGCTGGAGT	0.532000													28	57					1.75199e-13	1.7608e-13	1	1	0
FLNB	2317	broad.mit.edu	37	3	58155415	58155415	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58155415C>T	ENST00000295956.4	+	45	7681	c.7516C>T	c.(7516-7518)Ccc>Tcc	p.P2506S	FLNB_ENST00000358537.3_Missense_Mutation_p.P2482S|FLNB_ENST00000429972.2_Missense_Mutation_p.P2495S|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000490882.1_Missense_Mutation_p.P2537S|FLNB_ENST00000484981.1_3'UTR|FLNB_ENST00000348383.5_Missense_Mutation_p.P2465S|FLNB-AS1_ENST00000488720.1_RNA|FLNB_ENST00000419752.2_Missense_Mutation_p.P2326S|FLNB_ENST00000493452.1_Missense_Mutation_p.P2313S	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2506	Hinge 2 (By similarity).|Interaction with INPPL1.|Self-association site, tail (By similarity).				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TAGCGCCATTCCCAAGGCATC	0.587000													49	101					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34180243	34180243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:34180243C>T	ENST00000262622.3	+	2	834	c.76C>T	c.(76-78)Ctc>Ttc	p.L26F	CHST8_ENST00000438847.2_Missense_Mutation_p.L26F|CHST8_ENST00000434302.1_Missense_Mutation_p.L26F|CHST8_ENST00000604556.1_Missense_Mutation_p.L26F	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	26					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					TGCAGGCCTCCTCCTCTTCAT	0.642000													24	119					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	618098	618098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:618098C>T	ENST00000358353.3	-	15	2296	c.1974G>A	c.(1972-1974)tcG>tcA	p.S658S	CDHR5_ENST00000349570.7_Silent_p.S464S|CDHR5_ENST00000397542.2_Silent_p.S658S			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	658					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GCTTGTCCTCCGAGGGGCCGC	0.652000													4	42					0	0	1	0	0
FOXJ1	2302	broad.mit.edu	37	17	74134004	74134004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74134004G>A	ENST00000322957.6	-	3	1050	c.696C>T	c.(694-696)ccC>ccT	p.P232P		NM_001454.3	NP_001445.2	Q92949	FOXJ1_HUMAN	forkhead box J1	232					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|liver(1)|pancreas(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(166;0.187)			GGACAGCGCTGGGCTCCTGCG	0.726000													3	7					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76756929	76756929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76756929G>A	ENST00000536229.3	+	3	3604	c.2895G>A	c.(2893-2895)gcG>gcA	p.A965A	SALL3_ENST00000537592.2_Silent_p.A1170A|SALL3_ENST00000575389.2_Silent_p.A1098A			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		ACGCCCCCGCGAGACGCGGCC	0.627000													10	24					0	0	1	0	0
IGLV3-9	28804	broad.mit.edu	37	22	23162132	23162132	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23162132G>A	ENST00000390316.2	+	0	340																											GGCCCTCTGGGATCCCTGAGC	0.572000													28	56					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57843625	57843625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57843625C>T	ENST00000309668.2	+	2	1006	c.879C>T	c.(877-879)tcC>tcT	p.S293S	INHBC_ENST00000550133.1_Intron	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	293					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						TTGCTGCCTCCTTTCACACTG	0.602000													6	67					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17235032	17235032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:17235032G>A	ENST00000261381.6	-	7	1649	c.1565C>T	c.(1564-1566)tCc>tTc	p.S522F		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	522					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAGGGTGTAGGAGTAGAACTG	0.478000													36	313					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166246007	166246007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166246007G>A	ENST00000375437.2	+	27	5981	c.5691G>A	c.(5689-5691)acG>acA	p.T1897T	SCN2A_ENST00000375427.2_Silent_p.T1897T|SCN2A_ENST00000357398.3_Silent_p.T1897T|SCN2A_ENST00000283256.6_Silent_p.T1897T	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1897					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	AGCCCATTACGACCACGTTGA	0.448000													28	53					0	0	1	0	0
TFCP2L1	29842	broad.mit.edu	37	2	122007186	122007186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:122007186C>T	ENST00000263707.5	-	3	349	c.252G>A	c.(250-252)aaG>aaA	p.K84K		NM_014553.2	NP_055368.1	Q9NZI6	TF2L1_HUMAN	transcription factor CP2-like 1	84					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			cervix(1)|endometrium(4)|large_intestine(5)|lung(7)|ovary(1)|pancreas(2)|skin(1)|stomach(1)	22	Renal(3;0.01)					AGTCTCCCAGCTTCCGATTCT	0.458000													30	75					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8182167	8182167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8182167C>T	ENST00000600128.1	-	28	3886	c.3472G>A	c.(3472-3474)Gaa>Aaa	p.E1158K	FBN3_ENST00000601739.1_Missense_Mutation_p.E1158K|FBN3_ENST00000270509.2_Missense_Mutation_p.E1158K			Q75N90	FBN3_HUMAN	fibrillin 3	1158	EGF-like 16; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ACCCGGCATTCGTTGATGTCT	0.642000													7	29					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11218112	11218112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11218112G>A	ENST00000558518.1	+	6	1049	c.862G>A	c.(862-864)Gaa>Aaa	p.E288K	LDLR_ENST00000455727.2_Missense_Mutation_p.E120K|LDLR_ENST00000558013.1_Missense_Mutation_p.E288K|LDLR_ENST00000545707.1_Missense_Mutation_p.E161K|LDLR_ENST00000535915.1_Missense_Mutation_p.E247K|LDLR_ENST00000557933.1_Missense_Mutation_p.E288K	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	288	LDL-receptor class A 7.		E -> K (in FH; German patient).		cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	TCACAGCGGCGAATGCATCAC	0.562000													11	52					0	0	1	0	0
HEXB	3074	broad.mit.edu	37	5	73981299	73981299	+	Missense_Mutation	SNP	C	C	T	rs147155126	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:73981299C>T	ENST00000261416.7	+	1	331	c.214C>T	c.(214-216)Ctc>Ttc	p.L72F	HEXB_ENST00000511181.1_Intron	NM_000521.3	NP_000512.1	P07686	HEXB_HUMAN	hexosaminidase B (beta polypeptide)	72					cell death	lysosome	cation binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(3)|large_intestine(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.72e-57)		CCTGCTGCATCTCGCCCCGGA	0.706000													4	37					0	0	1	0	0
ANKS3	124401	broad.mit.edu	37	16	4776692	4776692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4776692G>A	ENST00000304283.4	-	5	753	c.459C>T	c.(457-459)ttC>ttT	p.F153F	ANKS3_ENST00000450067.2_Intron|ANKS3_ENST00000585773.1_Silent_p.F80F|ANKS3_ENST00000592711.1_Intron|ANKS3_ENST00000446014.2_Silent_p.F24F	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	153										endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						TGTCCAAGAGGAACCTGACCA	0.552000													27	44					0	0	1	0	0
RBM28	55131	broad.mit.edu	37	7	127950857	127950857	+	Missense_Mutation	SNP	T	T	C	rs148028531	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127950857T>C	ENST00000223073.1	-	19	2387	c.2273A>G	c.(2272-2274)gAt>gGt	p.D758G	RBM28_ENST00000415472.2_Missense_Mutation_p.D617G|RBM28_ENST00000481788.1_5'UTR	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	758					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						TCATCAACTATCAAACCATTT	0.502000													10	191					0	0	1	0	0
PLBD2	196463	broad.mit.edu	37	12	113825664	113825664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113825664C>T	ENST00000280800.3	+	11	1586	c.1555C>T	c.(1555-1557)Ccc>Tcc	p.P519S	PLBD2_ENST00000545182.2_Missense_Mutation_p.P487S	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	519					lipid catabolic process	lysosomal lumen	hydrolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						TGGCTCCTACCCCTTCCAGGC	0.637000													60	219					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157771953	157771953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157771953C>T	ENST00000358292.3	-	5	689	c.638G>A	c.(637-639)aGg>aAg	p.R213K	FCRL1_ENST00000491942.1_Missense_Mutation_p.R213K|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000368176.3_Missense_Mutation_p.R213K	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	213	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCTGGGAGCCCTGAGCATGAG	0.567000													28	44					0	0	1	0	0
SGCA	6442	broad.mit.edu	37	17	48245758	48245758	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48245758G>A	ENST00000262018.3	+	5	445	c.409G>A	c.(409-411)Gag>Aag	p.E137K	SGCA_ENST00000344627.6_Missense_Mutation_p.E137K|SGCA_ENST00000543315.1_Missense_Mutation_p.E137K|SGCA_ENST00000513942.1_3'UTR|SGCA_ENST00000451235.2_Missense_Mutation_p.E35K	NM_000023.2	NP_000014.1	Q16586	SGCA_HUMAN	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	137			E -> G (in LGMD2D; associated with P-G-A- Q-P-136 ins; dbSNP:rs28933694).|E -> K (in LGMD2D).		muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(2)|skin(1)	14						ATACCAAGCCGAGTTCCTGGT	0.677000													3	8					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113740500	113740500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113740500C>T	ENST00000397030.1	+	21	2446	c.2409C>T	c.(2407-2409)tcC>tcT	p.S803S	MCF2L_ENST00000375608.3_Silent_p.S800S|MCF2L_ENST00000421756.1_Silent_p.S774S|MCF2L_ENST00000375597.4_Silent_p.S768S|MCF2L_ENST00000375604.2_Silent_p.S827S|MCF2L_ENST00000375601.3_Silent_p.S774S|MCF2L_ENST00000423482.2_Silent_p.S768S|MCF2L_ENST00000535094.2_Silent_p.S770S|MCF2L_ENST00000434480.2_Silent_p.S776S|MCF2L_ENST00000442652.2_Silent_p.S800S			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	800	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CGCTGAGCTCCATCCTGGGCA	0.637000													15	32					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28764623	28764623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:28764623C>T	ENST00000422425.2	+	13	901	c.857C>T	c.(856-858)tCc>tTc	p.S286F	PLB1_ENST00000327757.5_Missense_Mutation_p.S275F	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	275	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GAGCAGGAGTCCTTCACCGTG	0.592000													18	38					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47279210	47279210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47279210G>A	ENST00000271153.4	+	5	588	c.552G>A	c.(550-552)gtG>gtA	p.V184V	CYP4B1_ENST00000371919.4_Silent_p.V169V|CYP4B1_ENST00000452782.2_Silent_p.V21V|CYP4B1_ENST00000371923.4_Silent_p.V184V			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	184					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TCTGCGATGTGGGTCACATGG	0.582000													19	67					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10265703	10265703	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10265703C>T	ENST00000418404.3	-	3	485	c.322G>A	c.(322-324)Gag>Aag	p.E108K	MYH13_ENST00000570743.1_Missense_Mutation_p.E108K|MYH13_ENST00000252172.4_Missense_Mutation_p.E108K			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	108	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GCATAGCGCTCTTTGAGGTTG	0.443000													60	81					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089883	9089883	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9089883C>T	ENST00000397910.4	-	1	2135	c.1932G>A	c.(1930-1932)acG>acA	p.T644T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	644	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGACACCGTTCGTGGCCAGAG	0.567000													34	94					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39425979	39425979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39425979G>A	ENST00000280481.7	+	11	7115	c.6899G>A	c.(6898-6900)gGa>gAa	p.G2300E		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2300	Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCCACCTCTGGAGAAGACTAC	0.527000													17	43					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123019089	123019089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123019089C>T	ENST00000462833.1	-	15	3990	c.2778G>A	c.(2776-2778)caG>caA	p.Q926Q	ADCY5_ENST00000491190.1_Silent_p.Q559Q|ADCY5_ENST00000309879.5_Silent_p.Q576Q	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	926					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TGCAGCTGATCTGCAGGAACA	0.637000													13	28					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507303	74507303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:74507303C>T	ENST00000354431.4	-	7	1503	c.1312G>A	c.(1312-1314)Gaa>Aaa	p.E438K	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.E438K	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	438								p.E438K(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						CTTACTTTTTCTTTATGGTAT	0.343000													47	107					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46653509	46653509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46653509C>T	ENST00000253255.5	-	1	5710	c.5711G>A	c.(5710-5712)aGc>aAc	p.S1904N		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1904					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CAGCCAATTGCTTTCTTGAAG	0.398000													34	89					0	0	1	0	0
OR4F6	390648	broad.mit.edu	37	15	102346532	102346532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:102346532G>A	ENST00000328882.4	+	1	631	c.610G>A	c.(610-612)Gga>Aga	p.G204R		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TGCCAATAGTGGATTTATTTC	0.343000													45	187					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48288033	48288033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48288033C>T	ENST00000435803.1	+	14	1881	c.1857C>T	c.(1855-1857)gtC>gtT	p.V619V		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	619					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ACCAGCTTGTCTCCACAGTGT	0.443000													65	124					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271747	59271747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59271747G>A	ENST00000313253.1	+	1	699	c.699G>A	c.(697-699)agG>agA	p.R233R		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						GAGGGGGCAGGAGGAAAGCCA	0.552000													81	166					0	0	1	0	0
GBP1P1	400759	broad.mit.edu	37	1	89886716	89886716	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89886716G>A	ENST00000513638.1	+	0	494					NR_003133.2																						AATAGCATAGGAACCATTAAC	0.522000													21	65					0	0	1	0	0
ABCA11P	79963	broad.mit.edu	37	4	420538	420538	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:420538G>A	ENST00000451020.2	-	0	500					NR_002451.2																						TTGTTGAAAAGCAACTTTCTT	0.393000													16	29					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174630	51174630	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51174630C>T	ENST00000440970.1	-	2	1643	c.1212G>A	c.(1210-1212)gaG>gaA	p.E404E	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.E501E|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	501					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GAGGGTATTTCTCTTTGTGGC	0.517000													30	87					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44560392	44560392	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44560392C>T	ENST00000289547.4	-	14	3163	c.3108G>A	c.(3106-3108)gtG>gtA	p.V1036V	NPC1L1_ENST00000381160.3_Silent_p.V1036V|NPC1L1_ENST00000546276.1_Silent_p.V990V	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1036					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AAGTCAAGTTCACAGAGGTGC	0.577000													24	88					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16000416	16000416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16000416G>A	ENST00000221700.5	-	7	830	c.735C>T	c.(733-735)ttC>ttT	p.F245F	CYP4F2_ENST00000592328.1_Silent_p.F245F|CYP4F2_ENST00000011989.7_Silent_p.F96F	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	245					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATAATACAGGAAGTCAATAT	0.552000													70	150					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32378891	32378891	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32378891C>T	ENST00000375200.1	+	15	2498	c.2133C>T	c.(2131-2133)ttC>ttT	p.F711F	RP4-553F4.6_ENST00000443171.1_RNA|RP4-553F4.6_ENST00000439444.1_RNA|RP4-553F4.6_ENST00000423074.1_RNA|ZNF341_ENST00000342427.2_Silent_p.F704F			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	711					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						ACTACAAGTTCCGCTGTGCTG	0.622000													23	45					0	0	1	0	0
FOXR1	283150	broad.mit.edu	37	11	118849510	118849510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118849510G>A	ENST00000317011.3	+	2	305	c.80G>A	c.(79-81)cGa>cAa	p.R27Q		NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1	27					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.R27Q(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TATAAACTCCGAATTGTTAAG	0.448000													46	132					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43813610	43813610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43813610G>A	ENST00000382031.1	+	5	684	c.653G>A	c.(652-654)gGa>gAa	p.G218E	MAP1A_ENST00000300231.5_5'UTR|MAP1A_ENST00000399453.1_5'UTR			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	0						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGCCACCTGGGATTATCCAGT	0.547000													16	80					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	18021541	18021541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18021541C>T	ENST00000262608.8	+	14	1835	c.1835C>T	c.(1834-1836)cCa>cTa	p.P612L	CECR2_ENST00000400573.4_Missense_Mutation_p.P611L|CECR2_ENST00000400585.2_Missense_Mutation_p.P470L	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	653	Poly-Ser.				chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		CCAGCAGTACCAGGAACATTT	0.542000													24	38					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204939816	204939816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204939816G>A	ENST00000367172.4	+	11	1404	c.1076G>A	c.(1075-1077)cGa>cAa	p.R359Q	NFASC_ENST00000404076.1_Missense_Mutation_p.R353Q|NFASC_ENST00000513543.1_Missense_Mutation_p.R370Q|NFASC_ENST00000367171.4_Missense_Mutation_p.R359Q|NFASC_ENST00000403080.1_Missense_Mutation_p.R359Q|NFASC_ENST00000339876.6_Missense_Mutation_p.R359Q|NFASC_ENST00000539706.1_Missense_Mutation_p.R370Q|NFASC_ENST00000404907.1_Missense_Mutation_p.R370Q|NFASC_ENST00000360049.4_Missense_Mutation_p.R370Q|NFASC_ENST00000367170.4_Missense_Mutation_p.R359Q|NFASC_ENST00000401399.1_Missense_Mutation_p.R359Q|NFASC_ENST00000367169.4_Missense_Mutation_p.R359Q|NFASC_ENST00000338586.6_Missense_Mutation_p.R359Q|NFASC_ENST00000338515.6_Missense_Mutation_p.R359Q			O94856	NFASC_HUMAN	neurofascin	359	Ig-like C2-type 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTGGTGTGTCGAGCCAATGGA	0.542000													21	68					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26689615	26689615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26689615G>A	ENST00000436292.1	-	5	1165	c.1045C>T	c.(1045-1047)Cca>Tca	p.P349S	ZNF683_ENST00000349618.3_Missense_Mutation_p.P349S|ZNF683_ENST00000403843.1_Missense_Mutation_p.P349S|ZNF683_ENST00000374204.1_Missense_Mutation_p.P349S			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		CACTGGAATGGACGCTCTCCA	0.602000													5	15					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76381981	76381981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76381981G>A	ENST00000357063.3	+	11	2978	c.1718G>A	c.(1717-1719)cGa>cAa	p.R573Q	LMO7_ENST00000341547.4_Intron|LMO7_ENST00000377534.3_Missense_Mutation_p.R573Q|LMO7_ENST00000321797.8_Missense_Mutation_p.R288Q|LMO7_ENST00000465261.2_Missense_Mutation_p.R288Q|LMO7_ENST00000526202.1_Intron			Q8WWI1	LMO7_HUMAN	LIM domain 7	573						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		ATTGTTCGCCGAATTCCAGCA	0.453000													11	125					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120007815	120007815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:120007815C>T	ENST00000371311.3	-	2	1089	c.835G>A	c.(835-837)Gaa>Aaa	p.E279K		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	279										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TCTTTCTCTTCCTCGCCTGCA	0.458000													210	149					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216405294	216405294	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216405294C>T	ENST00000366943.2	-	14	3380		c.e14+1		USH2A_ENST00000307340.3_Splice_Site|USH2A_ENST00000366942.3_Splice_Site			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)						maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAAAGATGTACCTTCCAGTCT	0.363000										HNSCC(13;0.011)			34	179					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56140423	56140423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56140423G>A	ENST00000319441.4	+	10	1596	c.1432G>A	c.(1432-1434)Gac>Aac	p.D478N	PCK1_ENST00000535860.1_3'UTR|PCK1_ENST00000543666.1_Missense_Mutation_p.D161N	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	478					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CATCATGCATGACCCCTTTGC	0.502000													35	80					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33412138	33412138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33412138G>A	ENST00000404816.2	+	6	1770	c.1417G>A	c.(1417-1419)Gga>Aga	p.G473R	LTBP1_ENST00000402934.1_Missense_Mutation_p.G147R|LTBP1_ENST00000354476.3_Missense_Mutation_p.G473R|LTBP1_ENST00000404525.1_Missense_Mutation_p.G147R|LTBP1_ENST00000407925.1_Missense_Mutation_p.G147R|LTBP1_ENST00000390003.4_Missense_Mutation_p.G147R|LTBP1_ENST00000418533.2_Missense_Mutation_p.G147R			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	473					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TAGCCAGCAAGGAGTCAAAGG	0.527000													15	55					0	0	1	0	0
PPP1R32	220004	broad.mit.edu	37	11	61257301	61257301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61257301G>A	ENST00000338608.2	+	12	1216	c.1091G>A	c.(1090-1092)cGa>cAa	p.R364Q	PPP1R32_ENST00000432063.2_Missense_Mutation_p.R344Q|PPP1R32_ENST00000366212.4_5'UTR|PPP1R32_ENST00000538185.1_Missense_Mutation_p.R41Q	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	364																	GGCTGGACTCGAGGTGGCATC	0.642000													14	34					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27228254	27228254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27228254C>T	ENST00000380036.4	+	22	3693	c.3251C>T	c.(3250-3252)tCa>tTa	p.S1084L	TEK_ENST00000519097.1_Missense_Mutation_p.S936L|TEK_ENST00000406359.4_Missense_Mutation_p.S1041L	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	1084	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GAGAGGCCATCATTTGCCCAG	0.413000													16	109					0	0	1	0	0
SEMA4B	10509	broad.mit.edu	37	15	90768248	90768248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90768248C>T	ENST00000411539.2	+	10	1503	c.1243C>T	c.(1243-1245)Ctc>Ttc	p.L415F	SEMA4B_ENST00000332496.6_Missense_Mutation_p.L415F|SEMA4B_ENST00000379122.3_Missense_Mutation_p.L410F	NM_198925.2	NP_945119.1			sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B											NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)	12	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			ATCCCTGCAGCTCCCAGACCG	0.627000													27	96					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269471	150269471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150269471C>T	ENST00000255945.2	+	3	488	c.313C>T	c.(313-315)Cgc>Tgc	p.R105C	GIMAP4_ENST00000461940.1_Missense_Mutation_p.R119C|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	105							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAGATTATTCGCTGCATTCT	0.522000													16	64					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169910	207169910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207169910G>A	ENST00000374423.3	+	5	1044	c.658G>A	c.(658-660)Gac>Aac	p.D220N		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	220							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TAGCAAATGTGACCCAAACAA	0.408000													6	37					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88767368	88767368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88767368G>A	ENST00000497649.2	+	6	1654	c.1276G>A	c.(1276-1278)Gaa>Aaa	p.E426K	MEPE_ENST00000560249.1_Missense_Mutation_p.E337K|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000424957.3_Missense_Mutation_p.E450K|MEPE_ENST00000540395.1_Missense_Mutation_p.E337K|MEPE_ENST00000361056.3_Missense_Mutation_p.E450K|MEPE_ENST00000395102.4_Missense_Mutation_p.E481K			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	450					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AATCAAAAACGAAATGGATTC	0.378000													13	64					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45284519	45284519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45284519G>A	ENST00000270279.3	+	3	619	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K	CBLC_ENST00000341505.4_Missense_Mutation_p.E186K	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	186	Cbl-PTB.|EF-hand-like.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				CCACCCTGTGGAACCAGGCTG	0.642000			M		AML								26	67					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38748773	38748773	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38748773G>A	ENST00000449082.2	-	25	4382	c.4383C>T	c.(4381-4383)ccC>ccT	p.P1461P		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1461					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGCTCACCAGGGGCCGTGGGA	0.547000													27	72					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150489234	150489234	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150489234G>A	ENST00000447204.2	-	6	1002	c.630C>T	c.(628-630)ttC>ttT	p.F210F	TMEM176B_ENST00000450753.2_Silent_p.F173F|TMEM176B_ENST00000492607.1_Silent_p.F210F|TMEM176B_ENST00000429904.2_Silent_p.F210F|TMEM176B_ENST00000326442.5_Silent_p.F210F|TMEM176B_ENST00000434545.1_Silent_p.F210F	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	210					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGACAGCCAGGAACAGGGCAC	0.522000													15	61					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12945613	12945613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12945613G>A	ENST00000589272.1	-	2	393	c.64C>T	c.(64-66)Ctc>Ttc	p.L22F	MAST1_ENST00000591495.1_Intron|RTBDN_ENST00000322912.5_Missense_Mutation_p.L22F|RTBDN_ENST00000393233.2_5'UTR			Q9BSG5	RTBDN_HUMAN	retbindin	0						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						AAGGTGGGGAGGGATTCTGTA	0.582000													16	58					0	0	1	0	0
SLC5A4	6527	broad.mit.edu	37	22	32650159	32650159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32650159G>A	ENST00000266086.4	-	2	188	c.177C>T	c.(175-177)ttC>ttT	p.F59F	RP1-90G24.10_ENST00000434942.1_RNA	NM_014227.2	NP_055042.1	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (glucose activated ion channel), member 4	59					carbohydrate transport|sodium ion transport	integral to membrane	symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|pancreas(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GACCAGCGAGGAAGAAGCCTC	0.532000													25	47					0	0	1	0	0
DDX54	79039	broad.mit.edu	37	12	113603608	113603608	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113603608G>A	ENST00000314045.7	-	13	1671	c.1645_splice	c.e13+1	p.F548_splice	DDX54_ENST00000306014.5_Splice_Site_p.F548_splice	NM_001111322.1	NP_001104792.1	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	548					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AGGACTCACTGAAGAGGGGGT	0.642000													10	29					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234915531	234915531	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234915531G>A	ENST00000324695.4	+	23	3205	c.3165G>A	c.(3163-3165)tgG>tgA	p.W1055*	TRPM8_ENST00000433712.2_Nonsense_Mutation_p.W633*	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	1055						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTCTGGCATGGGAGGGTGTCA	0.398000													13	30					0	0	1	0	0
NPPB	4879	broad.mit.edu	37	1	11918354	11918354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11918354C>T	ENST00000376468.3	-	2	402	c.305G>A	c.(304-306)cGa>cAa	p.R102Q		NM_002521.2	NP_002512.1	P16860	ANFB_HUMAN	natriuretic peptide B	102					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	CTTGGGGCTTCGTGGTGCCCG	0.642000													15	36					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88780705	88780705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88780705G>A	ENST00000418177.2	-	2	703	c.336C>T	c.(334-336)ttC>ttT	p.F112F	GRM5_ENST00000305447.4_Silent_p.F112F|GRM5_ENST00000393297.1_Silent_p.F112F|GRM5_ENST00000393294.3_Silent_p.F112F|GRM5_ENST00000455756.2_Silent_p.F112F|GRM5_ENST00000305432.5_Silent_p.F112F			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	112					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.F112L(2)		NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AATCTCTTATGAACTCAATGC	0.527000													28	36					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21327590	21327590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21327590C>T	ENST00000256958.2	+	4	402	c.306C>T	c.(304-306)ttC>ttT	p.F102F		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	102					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TCGGTTGTTTCATTATGGGAA	0.343000													14	70					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38131207	38131207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38131207C>T	ENST00000406386.3	+	9	5119	c.4864C>T	c.(4864-4866)Cct>Tct	p.P1622S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1622					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AAACGATGTCCCTGAGCAGGA	0.677000											OREG0026548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	67					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103124664	103124664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103124664C>T	ENST00000295269.4	+	5	1782	c.1325C>T	c.(1324-1326)cCt>cTt	p.P442L		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	442					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TTTTTGCTTCCTCTGTCTCTT	0.378000													31	60					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	31952984	31952984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31952984C>T	ENST00000432498.1	+	7	994	c.601C>T	c.(601-603)Cgt>Tgt	p.R201C	SFI1_ENST00000443011.1_Intron|SFI1_ENST00000443326.1_Missense_Mutation_p.R119C|SFI1_ENST00000540643.1_Missense_Mutation_p.R177C|SFI1_ENST00000414585.1_Intron|SFI1_ENST00000400288.2_Missense_Mutation_p.R201C|SFI1_ENST00000400289.1_Missense_Mutation_p.R119C	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	201					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						CGTGGTTGTTCGTAGGACCAA	0.468000													20	57					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24681389	24681389	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:24681389G>T	ENST00000396475.2	+	4	471	c.172G>T	c.(172-174)Gaa>Taa	p.E58*	MPP6_ENST00000222644.4_Nonsense_Mutation_p.E58*|MPP6_ENST00000409761.1_5'UTR	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	58	L27 2.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						CAATAACTTGGAATTAGTCAA	0.338000													32	79					2.08457e-15	2.09586e-15	1	1	0
SPNS3	201305	broad.mit.edu	37	17	4337325	4337325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4337325C>T	ENST00000355530.2	+	1	343	c.63C>T	c.(61-63)tcC>tcT	p.S21S	SPNS3_ENST00000576069.1_3'UTR|SPNS3_ENST00000333476.2_5'UTR	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	21					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						AGGGCCAGTCCCCAGGGCCAG	0.701000													11	21					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86010709	86010709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:86010709C>T	ENST00000383699.3	+	8	1509	c.882C>T	c.(880-882)ttC>ttT	p.F294F	CADM2_ENST00000407528.2_Silent_p.F285F|CADM2_ENST00000405615.2_Silent_p.F287F	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	285	Ig-like C2-type 2.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ACATTCTTTTCCTGAACAAAA	0.433000													42	111					0	0	1	0	0
C8orf47	203111	broad.mit.edu	37	8	99101747	99101747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:99101747G>A	ENST00000318528.3	+	2	861	c.502G>A	c.(502-504)Gac>Aac	p.D168N	C8orf47_ENST00000545282.1_Intron	NM_173549.2	NP_775820.2	Q6P6B1	CH047_HUMAN	chromosome 8 open reading frame 47	168										kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(2)	13	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			AGTAGAGAAGGACTCTCTCAG	0.517000													5	47					0	0	1	0	0
C1orf158	93190	broad.mit.edu	37	1	12820790	12820790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12820790C>T	ENST00000288048.5	+	4	707	c.491C>T	c.(490-492)tCa>tTa	p.S164L	C1orf158_ENST00000376210.3_Missense_Mutation_p.S126L	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	164										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		ACTTATACTTCATCCTACCCC	0.567000													34	86					0	0	1	0	0
NPPB	4879	broad.mit.edu	37	1	11918493	11918493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11918493C>T	ENST00000376468.3	-	2	263	c.166G>A	c.(166-168)Gag>Aag	p.E56K		NM_002521.2	NP_002512.1	P16860	ANFB_HUMAN	natriuretic peptide B	56					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	ACCTGCAGCTCCGACAGTTTG	0.657000													17	31					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	3040238	3040238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3040238G>A	ENST00000398052.4	+	15	2024	c.1681G>A	c.(1681-1683)Ggg>Agg	p.G561R	GRK4_ENST00000509545.1_3'UTR|GRK4_ENST00000345167.6_Missense_Mutation_p.G529R|GRK4_ENST00000504933.1_Intron|GRK4_ENST00000398051.4_Intron	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	561						cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTTCAGAAGAGGGGTAAAAAG	0.373000													19	84					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18330167	18330167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18330167C>T	ENST00000355502.3	-	12	1714	c.843G>A	c.(841-843)gaG>gaA	p.E281E	PDE4C_ENST00000539010.1_Silent_p.E50E|PDE4C_ENST00000594617.2_Silent_p.E281E|PDE4C_ENST00000262805.11_Silent_p.E249E|PDE4C_ENST00000594465.2_Silent_p.E281E|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000447275.2_Silent_p.E175E			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	281					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GTGGGGCCTCCTCAGCGGTCA	0.652000													10	49					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6457306	6457306	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6457306G>A	ENST00000358945.3	-	13	2249	c.1809C>T	c.(1807-1809)ttC>ttT	p.F603F	SCNN1A_ENST00000543768.1_Silent_p.F604F|SCNN1A_ENST00000396966.2_3'UTR|SCNN1A_ENST00000360168.3_Silent_p.F640F|SCNN1A_ENST00000228916.2_Silent_p.F581F|SCNN1A_ENST00000540037.1_Silent_p.F281F			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	581					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	GCAGCATGAGGAACATGATGA	0.617000													23	38					0	0	1	0	0
NFS1	9054	broad.mit.edu	37	20	34257603	34257603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34257603G>A	ENST00000374092.4	-	13	1385	c.1315C>T	c.(1315-1317)Ctc>Ttc	p.L439F	NFS1_ENST00000541387.1_Missense_Mutation_p.L388F|NFS1_ENST00000540053.1_Missense_Mutation_p.L237F|NFS1_ENST00000397425.1_Missense_Mutation_p.L379F|NFS1_ENST00000498084.1_5'UTR|NFS1_ENST00000374085.1_Missense_Mutation_p.L379F	NM_021100.4	NP_066923.3	Q9Y697	NFS1_HUMAN	NFS1 cysteine desulfurase	439					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	18	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	ATCTCCCAGAGAGGGCTGCCA	0.527000													35	72					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084376	53084376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:53084376C>T	ENST00000276480.7	-	10	1728	c.1045G>A	c.(1045-1047)Gga>Aga	p.G349R		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	349						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ATTTGTCTTCCACCCATGTCG	0.378000													43	125					0	0	1	0	0
PRSS22	64063	broad.mit.edu	37	16	2903927	2903927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2903927C>T	ENST00000161006.3	-	5	721	c.656G>A	c.(655-657)gGa>gAa	p.G219E	PRSS22_ENST00000571228.1_Missense_Mutation_p.G109E	NM_022119.3	NP_071402.1	Q9GZN4	BSSP4_HUMAN	protease, serine, 22	219	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|skin(2)	10						AGTGATGGGTCCCTGTCCTGC	0.637000													20	48					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67053896	67053896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:67053896G>A	ENST00000295568.4	+	3	558	c.427G>A	c.(427-429)Gat>Aat	p.D143N	KBTBD8_ENST00000417314.2_Missense_Mutation_p.D169N|KBTBD8_ENST00000460576.1_Intron|KBTBD8_ENST00000469661.1_Intron	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	169										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		GGAACTCGGAGATCGATCAAA	0.383000													20	79					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133795854	133795854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:133795854G>A	ENST00000321016.8	-	14	2044	c.1814C>T	c.(1813-1815)cCt>cTt	p.P605L	IGSF9B_ENST00000533871.2_Missense_Mutation_p.P605L			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	605						integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		AGTTGTAATAGGGAATGCTGC	0.647000													3	5					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54605263	54605263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54605263C>T	ENST00000371330.1	-	4	2127	c.1280G>A	c.(1279-1281)gGa>gAa	p.G427E	CDCP2_ENST00000530059.1_Intron	NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	427						extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						TCTTAGGGGTCCCGAGAGTGG	0.582000													16	31					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	336757	336757	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:336757G>C	ENST00000343164.4	-	8	961	c.909C>G	c.(907-909)taC>taG	p.Y303*	SLC6A13_ENST00000445055.2_Nonsense_Mutation_p.Y211*	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	303					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GGTACTTGTTGTAGCTGCCCA	0.562000													17	39					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37707082	37707082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37707082C>T	ENST00000248901.6	+	10	1049	c.862C>T	c.(862-864)Ctc>Ttc	p.L288F		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	288	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CGACAACTGCCTCTACTACTT	0.627000													48	128					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16282772	16282772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16282772C>T	ENST00000205557.7	-	13	1724	c.1695G>A	c.(1693-1695)gaG>gaA	p.E565E	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	565	ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CAAAGGCTTTCTCTGCATTCA	0.582000													17	46					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94495007	94495007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94495007G>A	ENST00000370225.3	-	30	4619	c.4533C>T	c.(4531-4533)ccC>ccT	p.P1511P		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1511					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GTACCTGGGGGGGCGGGAGGC	0.627000													6	5					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886742	23886742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23886742G>A	ENST00000355349.3	-	31	4485	c.4323C>T	c.(4321-4323)gcC>gcT	p.A1441A		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1441					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCTTGTCCAGGGCTGCAGCAG	0.612000													42	121					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79029900	79029900	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79029900C>T	ENST00000446378.2	+	2	5343	c.5312C>T	c.(5311-5313)cCa>cTa	p.P1771L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1771						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAAATAGGCCCATTACCACCA	0.408000													31	70					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104703895	104703895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:104703895C>T	ENST00000334877.4	+	5	818	c.284C>T	c.(283-285)cCt>cTt	p.P95L	KMT2E_ENST00000476671.1_Missense_Mutation_p.P95L|KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000311117.3_Missense_Mutation_p.P95L|KMT2E_ENST00000257745.4_Missense_Mutation_p.P95L					lysine (K)-specific methyltransferase 2E																		TTTACCACTCCTAATTTTGAT	0.438000													37	101					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272640	52272640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52272640C>T	ENST00000598776.1	+	2	1501	c.729C>T	c.(727-729)ctC>ctT	p.L243L	FPR2_ENST00000340023.6_Silent_p.L243L|FPR2_ENST00000598953.1_Silent_p.L243L	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	243					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						TACGGGTCCTCACTGCTGTGG	0.498000													26	48					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211158482	211158482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211158482C>T	ENST00000352451.3	-	5	668	c.521G>A	c.(520-522)gGt>gAt	p.G174D	MYL1_ENST00000341685.4_Missense_Mutation_p.G130D|MYL1_ENST00000496436.1_5'UTR	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	174	EF-hand 3.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GTCTTCTTGACCTGCCATCAG	0.428000													51	216					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47786986	47786986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47786986C>T	ENST00000359568.5	+	15	3204	c.3097C>T	c.(3097-3099)Cac>Tac	p.H1033Y	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1033					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					TGTGCGGGACCACCTGCGAAC	0.587000													28	81					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96788538	96788538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96788538G>A	ENST00000359933.4	-	18	3683	c.2790C>T	c.(2788-2790)atC>atT	p.I930I		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	930										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GAGAATTGCTGATTGCTTTAT	0.333000													30	50					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35823538	35823538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35823538G>A	ENST00000085219.5	+	3	189	c.123G>A	c.(121-123)tgG>tgA	p.W41*	CD22_ENST00000595419.1_3'UTR|CD22_ENST00000419549.2_5'UTR|CD22_ENST00000341773.6_Nonsense_Mutation_p.W41*|CD22_ENST00000536635.2_Nonsense_Mutation_p.W41*|CD22_ENST00000270311.6_5'UTR|CD22_ENST00000544992.2_Nonsense_Mutation_p.W41*|CD22_ENST00000594250.1_Nonsense_Mutation_p.W41*	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	41	Ig-like V-type.				cell adhesion		protein binding|sugar binding	p.W41*(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CCTGCGTCTGGATCCCCTGCA	0.502000													30	81					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218700808	218700808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:218700808G>A	ENST00000171887.4	-	18	3211	c.2759C>T	c.(2758-2760)tCc>tTc	p.S920F	TNS1_ENST00000419504.1_Missense_Mutation_p.S920F|TNS1_ENST00000430930.1_Missense_Mutation_p.S920F	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	920						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CTGGACAGGGGAGCGAACCCC	0.622000													37	66					0	0	1	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862608	25862608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25862608C>T	ENST00000397060.4	-	3	265	c.156G>A	c.(154-156)acG>acA	p.T52T	SLC17A3_ENST00000361703.6_Silent_p.T52T|SLC17A3_ENST00000360657.3_Silent_p.T52T	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	52					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						TTTGTGCTATCGTTGTGAAAT	0.413000													28	119					0	0	1	0	0
OR1I1	126370	broad.mit.edu	37	19	15198561	15198561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15198561C>T	ENST00000209540.2	+	1	771	c.685C>T	c.(685-687)Cct>Tct	p.P229S		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						CTTTAAGATCCCTTCTACTCG	0.517000													22	61					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115335717	115335717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115335717C>T	ENST00000537906.1	+	5	413	c.251C>T	c.(250-252)tCa>tTa	p.S84L	HABP2_ENST00000542051.1_Silent_p.F69F|HABP2_ENST00000541666.1_Silent_p.F95F|HABP2_ENST00000351270.3_Silent_p.F95F			Q14520	HABP2_HUMAN	hyaluronan binding protein 2	0	EGF-like 1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		GGAGCACCTTCACATGCAGCT	0.527000													39	145					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155774872	155774872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155774872G>A	ENST00000437809.1	-	11	1635	c.1513C>T	c.(1513-1515)Ccc>Tcc	p.P505S	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Missense_Mutation_p.P505S|GON4L_ENST00000368331.1_Missense_Mutation_p.P505S|GON4L_ENST00000271883.5_Missense_Mutation_p.P505S			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	505					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGGCCCAGGGGAACATCTTTC	0.498000													41	101					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595335	179595335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179595335G>A	ENST00000589042.1	-	61	18149	c.17925C>T	c.(17923-17925)ttC>ttT	p.F5975F	TTN_ENST00000342992.6_Silent_p.F4731F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.F5658F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5658	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATTTCCAAGAAGGCAGTAT	0.453000													24	114					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38840443	38840443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38840443G>A	ENST00000359357.3	+	48	6725	c.6471G>A	c.(6469-6471)atG>atA	p.M2157I	DNAH8_ENST00000449981.2_Missense_Mutation_p.M2374I|DNAH8_ENST00000441566.1_Missense_Mutation_p.M2121I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AAATGCGAATGAATCCAAAAG	0.453000													27	73					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42747230	42747230	+	Silent	SNP	C	C	T	rs138017620		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42747230C>T	ENST00000372980.3	-	3	2075	c.1203G>A	c.(1201-1203)gcG>gcA	p.A401A		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	401	Ala-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGGCCTGTTCCGCTGCCTCAG	0.617000													33	149					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52131192	52131192	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52131192T>A	ENST00000222107.4	-	5	1030	c.892A>T	c.(892-894)Atc>Ttc	p.I298F	SIGLEC5_ENST00000429354.3_Missense_Mutation_p.I298F|SIGLEC5_ENST00000534261.2_Missense_Mutation_p.I298F|SIGLEC5_ENST00000599649.1_Missense_Mutation_p.I298F|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.I298F			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	298	Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		AGCTCCAAGATCCCGGTATTG	0.597000													37	103					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54903692	54903692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54903692G>A	ENST00000293373.6	+	7	737	c.658G>A	c.(658-660)Gag>Aag	p.E220K	NCKAP1L_ENST00000552211.1_3'UTR|NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E170K	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	220					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CCAGGGGGCTGAGCAGTGGCG	0.507000													69	131					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32891138	32891138	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32891138C>T	ENST00000330048.5	-	0	2925					NR_003083.2																						ATGGAGAGATCAATGACAAAG	0.597000													25	104					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358358	10358358	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10358358C>T	ENST00000255381.2	-	21	2445	c.2335G>A	c.(2335-2337)Gaa>Aaa	p.E779K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	779	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TCTCGCATTTCCTCTAGAGTT	0.418000													28	41					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150731895	150731895	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150731895C>T	ENST00000358849.4	+	5	837	c.744C>T	c.(742-744)tcC>tcT	p.S248S	ABCB8_ENST00000498578.1_Silent_p.S248S|ABCB8_ENST00000477092.1_Silent_p.S248S|ABCB8_ENST00000356058.4_Silent_p.S285S|ABCB8_ENST00000477719.1_Silent_p.S248S|ABCB8_ENST00000297504.6_Silent_p.S265S|ABCB8_ENST00000542328.1_Silent_p.S160S	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	265	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.S248S(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTAAGTCATCCTTCAAGCTTG	0.572000													10	44					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072128	9072128	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9072128G>A	ENST00000397910.4	-	3	15521	c.15318C>T	c.(15316-15318)gcC>gcT	p.A5106A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5108	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTTTAGAAGTGGCCAGTATCT	0.428000													45	96					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31652321	31652321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31652321C>T	ENST00000375494.3	+	7	711	c.711C>T	c.(709-711)ctC>ctT	p.L237L		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	237	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										CATTGCCTCTCATCTCCAACC	0.587000													11	44					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173883494	173883494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:173883494G>A	ENST00000264111.6	+	22	2303	c.2116G>A	c.(2116-2118)Gag>Aag	p.E706K	RAPGEF4_ENST00000409036.1_Missense_Mutation_p.E707K|RAPGEF4_ENST00000539331.1_Missense_Mutation_p.E554K|RAPGEF4_ENST00000538974.1_Missense_Mutation_p.E536K|RAPGEF4_ENST00000397087.3_Missense_Mutation_p.E563K|RAPGEF4_ENST00000535187.1_Missense_Mutation_p.E487K|RAPGEF4_ENST00000540783.1_Missense_Mutation_p.E554K|RAPGEF4_ENST00000397081.3_Missense_Mutation_p.E707K			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	707					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GGGCTCCGGGGAGGGCCTGAT	0.502000													19	100					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139905714	139905714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139905714G>A	ENST00000265662.5	-	38	5994	c.5847C>T	c.(5845-5847)ttC>ttT	p.F1949F	ABCA2_ENST00000371605.3_Silent_p.F1948F|ABCA2_ENST00000341511.6_Silent_p.F1949F			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1948					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGTAGTTGGGGAAAATGAGGA	0.617000													5	36					0	0	1	0	0
BFAR	51283	broad.mit.edu	37	16	14738443	14738443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:14738443C>T	ENST00000426842.2	+	1	299	c.61C>T	c.(61-63)Ccc>Tcc	p.P21S	BFAR_ENST00000261658.2_Silent_p.F80F|BFAR_ENST00000563971.1_Silent_p.F80F			Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	0					anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						GGGAAGGTTTCCCCAAAGTCA	0.408000													39	108					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25965266	25965266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:25965266G>A	ENST00000435504.4	-	13	4233	c.3940C>T	c.(3940-3942)Ccg>Tcg	p.P1314S	ASXL2_ENST00000272341.4_Missense_Mutation_p.P797S|ASXL2_ENST00000336112.4_Missense_Mutation_p.P1286S|ASXL2_ENST00000404843.1_Missense_Mutation_p.P797S			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	1314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACAACTTCGGGGTTTGCAGG	0.557000													5	10					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087437	92087437	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92087437G>A	ENST00000298047.6	+	1	2176	c.2159G>A	c.(2158-2160)aGa>aAa	p.R720K	FAT3_ENST00000541502.1_Missense_Mutation_p.R720K|FAT3_ENST00000409404.2_Missense_Mutation_p.R720K|FAT3_ENST00000525166.1_Missense_Mutation_p.R570K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	720					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.R720I(2)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCAATTAATAGACAGGGACCA	0.403000										TCGA Ovarian(4;0.039)			63	183					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241528843	241528843	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241528843C>T	ENST00000391984.2	+	2	421	c.225C>T	c.(223-225)ttC>ttT	p.F75F	CAPN10_ENST00000354082.4_Silent_p.F75F|CAPN10_ENST00000270364.7_Silent_p.F75F|CAPN10_ENST00000391982.2_Silent_p.F75F|CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000404753.3_Silent_p.F75F	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	75	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		ATTGCTGGTTCCTGTGTGCCT	0.602000													51	120					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97082687	97082687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:97082687G>A	ENST00000335456.7	-	6	1146	c.1126C>T	c.(1126-1128)Ccc>Tcc	p.P376S	NUTM2F_ENST00000341207.4_Missense_Mutation_p.P376S|NUTM2F_ENST00000253262.4_Missense_Mutation_p.P391S					NUT family member 2F																		ACTTCAGGGGGGATCTCCTCA	0.662000													46	70					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152647133	152647133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152647133G>A	ENST00000367255.5	-	80	15999	c.15398C>T	c.(15397-15399)tCg>tTg	p.S5133L	SYNE1_ENST00000341594.5_Intron|SYNE1_ENST00000423061.1_Missense_Mutation_p.S5062L|SYNE1_ENST00000448038.1_Missense_Mutation_p.S5062L|SYNE1_ENST00000265368.4_Missense_Mutation_p.S5133L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5133					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGACTAGACGAAGTCTTCAA	0.348000										HNSCC(10;0.0054)			22	28					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947903	237947903	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237947903C>T	ENST00000366574.2	+	90	13208	c.12891C>T	c.(12889-12891)ttC>ttT	p.F4297F	RYR2_ENST00000360064.6_Silent_p.F4303F|RYR2_ENST00000542537.1_Silent_p.F4281F	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4297					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTTGCACTTCGTGGCCAGCG	0.463000													16	39					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107601054	107601054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107601054G>A	ENST00000393561.1	-	16	2406	c.2222C>T	c.(2221-2223)aCc>aTc	p.T741I	LAMB1_ENST00000222399.6_Missense_Mutation_p.T717I|LAMB1_ENST00000393560.1_Missense_Mutation_p.T717I			P07942	LAMB1_HUMAN	laminin, beta 1	717	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCTCCCACGGTGAAGATGTC	0.493000													17	59					0	0	1	0	0
CCDC138	165055	broad.mit.edu	37	2	109489954	109489954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:109489954C>T	ENST00000295124.4	+	14	1801	c.1741C>T	c.(1741-1743)Cgt>Tgt	p.R581C	CCDC138_ENST00000412964.2_Intron	NM_144978.1	NP_659415.1	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	581										endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	14						TTTATTTTTTCGTACTTGCTC	0.368000													42	87					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81929530	81929530	+	Silent	SNP	G	G	A	rs149315555	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81929530G>A	ENST00000359376.3	+	13	1405	c.1191G>A	c.(1189-1191)tcG>tcA	p.S397S		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	397	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						TTGTTACCTCGAGGTCAGTTG	0.542000													56	67					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38765020	38765020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38765020C>T	ENST00000449082.2	-	18	3252	c.3253G>A	c.(3253-3255)Gag>Aag	p.E1085K		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1085					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTGCTGCCCTCAGAGGAGCTT	0.597000													4	13					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130841476	130841476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130841476C>T	ENST00000245255.3	+	13	1690	c.1418C>T	c.(1417-1419)cCa>cTa	p.P473L		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	473					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GATTACAATCCACAATTTGCA	0.368000													35	33					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98514412	98514412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:98514412C>T	ENST00000268042.6	+	8	1416	c.1252C>T	c.(1252-1254)Ctc>Ttc	p.L418F	ARRDC4_ENST00000538249.1_Missense_Mutation_p.L331F	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	418					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TTCCTTCATTCTCTGAACGTA	0.398000													12	177					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461804	11461804	+	Missense_Mutation	SNP	C	C	T	rs150367358	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11461804C>T	ENST00000279575.1	-	3	146	c.113G>A	c.(112-114)gGa>gAa	p.G38E	PRB4_ENST00000535904.1_Missense_Mutation_p.G38E|PRB4_ENST00000445719.2_Missense_Mutation_p.G38E	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	38	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.			LISGKPEGR -> IIPPKPPG (in Ref. 5; AA sequence).		extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						TGGGCGTCGTCCTTCTGGCTT	0.537000										HNSCC(22;0.051)			31	279					0	0	1	0	0
ANKRD7	56311	broad.mit.edu	37	7	117874902	117874902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117874902G>A	ENST00000357099.4	+	4	675	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K	ANKRD7_ENST00000417525.1_Missense_Mutation_p.E95K|ANKRD7_ENST00000477532.1_3'UTR|ANKRD7_ENST00000433239.1_Missense_Mutation_p.E95K|ANKRD7_ENST00000265224.4_Missense_Mutation_p.E148K			Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	148					male gonad development					breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)	29						GCTTGAATACGAAGCTGATCT	0.333000													10	45					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77415255	77415255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77415255G>A	ENST00000451710.3	-	17	2390	c.2153C>T	c.(2152-2154)cCc>cTc	p.P718L	TRPM6_ENST00000376864.4_Missense_Mutation_p.P718L|TRPM6_ENST00000449912.2_Missense_Mutation_p.P713L|TRPM6_ENST00000360774.1_Missense_Mutation_p.P718L|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.P713L|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	718					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TGAAACAAAGGGTCGTAATCC	0.463000													16	56					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108380691	108380691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108380691C>T	ENST00000265843.4	-	6	5653	c.5543G>A	c.(5542-5544)aGa>aAa	p.R1848K	EXPH5_ENST00000428840.1_Missense_Mutation_p.R1772K|EXPH5_ENST00000443411.1_Missense_Mutation_p.R1660K|EXPH5_ENST00000525344.1_Missense_Mutation_p.R1841K	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1848					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AGATCTGAATCTTCGACTGTA	0.458000													22	41					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43441229	43441229	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43441229G>A	ENST00000446844.3	-	0	89				PSG7_ENST00000406070.2_RNA|PSG7_ENST00000471557.1_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GGGGCCCCATGGTCTCTGCTC	0.577000													20	139					0	0	1	0	0
INO80E	283899	broad.mit.edu	37	16	30016748	30016748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30016748C>T	ENST00000563197.1	+	7	1737	c.720C>T	c.(718-720)atC>atT	p.I240I	INO80E_ENST00000304516.7_Silent_p.I201I|INO80E_ENST00000567705.1_Silent_p.I223I	NM_173618.1	NP_775889.1	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	240					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	6						ACCTGGTGATCGACATCCCGG	0.662000											OREG0023725	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	11					0	0	1	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77310494	77310494	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77310494G>A	ENST00000558012.1	+	2	531	c.42G>A	c.(40-42)agG>agA	p.R14R	PSTPIP1_ENST00000267939.5_Silent_p.R13R|PSTPIP1_ENST00000559295.1_Silent_p.R14R|PSTPIP1_ENST00000379595.3_Silent_p.R14R	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	14	FCH.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						CACAGTGCAGGGACTTCACAG	0.607000													3	6					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15132462	15132462	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15132462G>A	ENST00000292574.3	+	5	1158	c.1076G>A	c.(1075-1077)gGa>gAa	p.G359E		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	359					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						CTGATGAGGGGAACTATCCTC	0.582000													7	65					0	0	1	0	0
MYL2	4633	broad.mit.edu	37	12	111353546	111353546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111353546C>T	ENST00000228841.8	-	3	189	c.142G>A	c.(142-144)Gat>Aat	p.D48N	MYL2_ENST00000548438.1_Intron	NM_000432.3	NP_000423.2	P10916	MLRV_HUMAN	myosin, light chain 2, regulatory, cardiac, slow	48	EF-hand 1.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle	p.D48Y(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	12						TCTCTCAGATCGTTCTTGTCA	0.527000													59	128					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43413171	43413171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43413171G>A	ENST00000310826.5	-	3	1217	c.1034C>T	c.(1033-1035)tCg>tTg	p.S345L	ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398511.3_Missense_Mutation_p.S345L|ZBTB21_ENST00000398505.3_Missense_Mutation_p.S345L|ZBTB21_ENST00000398499.1_Missense_Mutation_p.S345L	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		GCTATCCATCGACAATGACCG	0.478000													25	52					0	0	1	0	0
EIF3F	8665	broad.mit.edu	37	11	8014500	8014500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8014500C>T	ENST00000533626.1	+	6	1208	c.582C>T	c.(580-582)gcC>gcT	p.A194A	EIF3F_ENST00000449102.2_Silent_p.A45A|EIF3F_ENST00000537635.1_Silent_p.A209A|EIF3F_ENST00000309828.4_Silent_p.A194A			O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3, subunit F	194	MPN.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)	13				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCCGAGAGGCCCCCAACCCCA	0.562000													26	109					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121694075	121694075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121694075C>T	ENST00000393386.2	+	26	6775	c.6364C>T	c.(6364-6366)Cct>Tct	p.P2122S	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.P1255S	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2122	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GGTTATGATTCCTGATGGCCA	0.428000													54	123					0	0	1	0	0
PRR5	55615	broad.mit.edu	37	22	45128160	45128160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45128160C>T	ENST00000403581.1	+	8	1122	c.513C>T	c.(511-513)gcC>gcT	p.A171A	PRR5-ARHGAP8_ENST00000361473.5_Intron|PRR5_ENST00000477331.1_3'UTR|ARHGAP8_ENST00000389773.5_Intron|PRR5_ENST00000336985.6_Silent_p.A148A|PRR5-ARHGAP8_ENST00000352766.7_Silent_p.A148A|ARHGAP8_ENST00000517296.3_Silent_p.A148A	NM_001198721.1	NP_001185650.1			proline rich 5 (renal)											central_nervous_system(1)|endometrium(2)|lung(6)|prostate(1)|skin(1)	11		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		GCCAGCTGGCCCTGCTGCACT	0.672000													13	43					0	0	1	0	0
DTL	51514	broad.mit.edu	37	1	212276201	212276201	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:212276201C>T	ENST00000366991.4	+	15	2426	c.2112C>T	c.(2110-2112)agC>agT	p.S704S	DTL_ENST00000542077.1_Silent_p.S662S|DTL_ENST00000475419.1_3'UTR	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	704					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		TCACGCCCAGCTCCATGAGGA	0.388000													20	43					0	0	1	0	0
ARMC1	55156	broad.mit.edu	37	8	66517673	66517673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:66517673G>A	ENST00000276569.3	-	5	810	c.566C>T	c.(565-567)tCa>tTa	p.S189L	ARMC1_ENST00000458464.2_Missense_Mutation_p.S87L	NM_018120.4	NP_060590.1	Q9NVT9	ARMC1_HUMAN	armadillo repeat containing 1	189					metal ion transport		metal ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(8)|skin(1)	14			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			TTTCAAATCTGAACGGATTCG	0.333000													20	78					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72050250	72050250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72050250G>A	ENST00000355327.3	+	15	2559	c.2425G>A	c.(2425-2427)Gag>Aag	p.E809K	THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000357769.4_Missense_Mutation_p.E449K|THSD4_ENST00000261862.6_Missense_Mutation_p.E809K			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	809	TSP type-1 4.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GTGCTCAGCGGAGTGTGGGGC	0.612000													20	74					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	20998468	20998468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20998468G>A	ENST00000247986.2	-	12	2995	c.2685C>T	c.(2683-2685)atC>atT	p.I895I	KIF17_ENST00000490034.1_5'UTR|KIF17_ENST00000400463.3_Silent_p.I895I|KIF17_ENST00000375044.1_Silent_p.I795I			Q9P2E2	KIF17_HUMAN	kinesin family member 17	895					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CGGGATGTGGGATCTTCCAGA	0.572000													14	103					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59182605	59182605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:59182605G>A	ENST00000380516.2	-	15	2041	c.1954C>T	c.(1954-1956)Cgt>Tgt	p.R652C	SLTM_ENST00000536328.1_Missense_Mutation_p.R221C|AC025918.2_ENST00000452467.1_RNA	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	652	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCCCGTTCACGAATTATTCTA	0.433000													52	105					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174260	51174260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51174260C>T	ENST00000440970.1	-	2	2013	c.1582G>A	c.(1582-1584)Gaa>Aaa	p.E528K	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.E625K|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	625					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCACTCTCTTCGCTTTTGCCA	0.642000													11	49					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12711222	12711222	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12711222G>A	ENST00000376221.1	+	2	249	c.249G>A	c.(247-249)aaG>aaA	p.K83K		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	83						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GAATTAAAAAGGACCCTGAAC	0.483000													45	114					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234549	21234549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21234549C>T	ENST00000233242.1	-	26	5318	c.5191G>A	c.(5191-5193)Gtc>Atc	p.V1731I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1731					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCTTGACTGACCTTGAAGTTG	0.448000													75	274					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121694076	121694076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121694076C>T	ENST00000393386.2	+	26	6776	c.6365C>T	c.(6364-6366)cCt>cTt	p.P2122L	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.P1255L	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2122	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GTTATGATTCCTGATGGCCAA	0.428000													54	123					0	0	1	0	0
IFNA21	3452	broad.mit.edu	37	9	21166096	21166096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21166096C>T	ENST00000380225.1	-	1	563	c.516G>A	c.(514-516)atG>atA	p.M172I		NM_002175.2	NP_002166.2	P01568	IFN21_HUMAN	interferon, alpha 21	172					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)	14				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGAAGGATCTCATGATTTCTG	0.383000													33	314					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159783292	159783292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159783292C>T	ENST00000321935.6	+	8	1130	c.1044C>T	c.(1042-1044)tcC>tcT	p.S348S	FCRL6_ENST00000392235.3_Silent_p.S246S|FCRL6_ENST00000339348.5_Silent_p.S341S|FCRL6_ENST00000368106.3_Silent_p.S341S			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	341						integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					CCCTTCCATCCCAGATACCAC	0.557000													22	86					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106552875	106552875	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:106552875C>T	ENST00000369096.4	+	5	1074	c.840C>T	c.(838-840)ctC>ctT	p.L280L	PRDM1_ENST00000369091.2_Silent_p.L244L|PRDM1_ENST00000369089.3_Silent_p.L146L	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	280					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		AAAAGGACCTCGATGACTTTA	0.507000			"""D, N, Mis, F, S"""		DLBCL								44	199					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573155	38573155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38573155C>T	ENST00000222345.6	+	3	1459	c.950C>T	c.(949-951)tCc>tTc	p.S317F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	317					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCTGGGCGTTCCCCGGGGGAG	0.687000													4	20					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72324234	72324234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72324234G>A	ENST00000263563.6	+	19	2645	c.2377G>A	c.(2377-2379)Gcc>Acc	p.A793T		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CCTGGAGAAGGCCGACTCCTG	0.642000													49	134					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44468071	44468071	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44468071G>A	ENST00000372310.3	-	8	1041	c.876C>T	c.(874-876)gcC>gcT	p.A292A	SLC6A9_ENST00000372307.3_Silent_p.A227A|SLC6A9_ENST00000357730.2_Silent_p.A311A|SLC6A9_ENST00000372306.3_Silent_p.A292A|SLC6A9_ENST00000360584.2_Silent_p.A365A|SLC6A9_ENST00000475075.2_Silent_p.A181A|SLC6A9_ENST00000537678.1_Silent_p.A227A	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	365						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	AGATCTGGGAGGCAGCATCAC	0.627000													14	98					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176708836	176708836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176708836G>A	ENST00000367662.3	+	13	5037	c.3873G>A	c.(3871-3873)gaG>gaA	p.E1291E		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1291					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTCCCGGAGAGCATCAGCAGC	0.458000													36	64					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12856145	12856145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12856145G>A	ENST00000332296.7	+	4	1528	c.1425G>A	c.(1423-1425)taG>taA	p.*475*	PRAMEF1_ENST00000400814.3_Silent_p.*230*	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	0										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTTGCTGCTAGGGAAGGCGTG	0.517000													17	137					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256006	15256006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15256006C>T	ENST00000378116.4	-	8	1587	c.1581G>A	c.(1579-1581)gaG>gaA	p.E527E		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	527						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GCTGTTCTTTCTCAGGTGATG	0.537000													28	225					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400661	85400661	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85400661C>T	ENST00000258888.5	+	6	3465	c.3298C>T	c.(3298-3300)Ctg>Ttg	p.L1100L		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1100					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCCACCTTCCTGCCCTCTGA	0.627000													22	77					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24832642	24832642	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24832642G>A	ENST00000376451.2	+	14	3752	c.3492G>A	c.(3490-3492)gaG>gaA	p.E1164E	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000376454.3_Silent_p.E1481E			Q5T5P2	SKT_HUMAN	KIAA1217	1481					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						aaaagatagaggaggaggaag	0.448000													6	51					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2752230	2752230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2752230G>A	ENST00000312371.4	+	7	1583	c.1215G>A	c.(1213-1215)aaG>aaA	p.K405K	AMZ1_ENST00000489665.1_Intron|AMZ1_ENST00000407112.1_3'UTR	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	405							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		AGGCCATCAAGGAGCATGAAC	0.687000													6	13					0	0	1	0	0
STRIP1	85369	broad.mit.edu	37	1	110596312	110596312	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110596312C>T	ENST00000369795.3	+	21	2314	c.2292C>T	c.(2290-2292)ttC>ttT	p.F764F	STRIP1_ENST00000369796.1_Silent_p.F669F	NM_033088.2	NP_149079.2			striatin interacting protein 1																		CTTGGGACTTCCAGGCAGAGG	0.582000											OREG0013647	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	68					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27157863	27157863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27157863C>T	ENST00000380036.4	+	2	529	c.87C>T	c.(85-87)atC>atT	p.I29I	TEK_ENST00000519097.1_Intron|TEK_ENST00000406359.4_Silent_p.I29I	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	29					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TGATCTTGATCAATTCCCTAC	0.463000													83	163					0	0	1	0	0
SNORD114-3	767579	broad.mit.edu	37	14	101419695	101419695	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101419695G>A	ENST00000364969.1	+	0	10					NR_003195.1																						ATGGACCAATGATGACCACTG	0.478000													16	108					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149490673	149490673	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149490673G>A	ENST00000378016.2	+	0	6047							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTGGTGGAGGGGACGGGAGAA	0.642000													16	29					0	0	1	0	0
SP6	80320	broad.mit.edu	37	17	45925633	45925633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45925633G>A	ENST00000536300.1	-	2	494	c.163C>T	c.(163-165)Ctc>Ttc	p.L55F	SP6_ENST00000342234.2_Missense_Mutation_p.L55F	NM_001258248.1	NP_001245177.1	Q3SY56	SP6_HUMAN	Sp6 transcription factor	55					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(5)|prostate(1)|skin(1)	8						CCCAGCGGGAGGCTCTGCAGC	0.692000													10	16					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45679538	45679538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45679538C>T	ENST00000270172.3	-	4	691	c.208G>A	c.(208-210)Gga>Aga	p.G70R	DNMT3L_ENST00000418993.1_Missense_Mutation_p.G70R	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	70	ADD.				DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		CAGATCCCTCCCTCAAACAGA	0.552000													7	25					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34090712	34090712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34090712G>A	ENST00000373381.4	-	34	5615	c.5439C>T	c.(5437-5439)atC>atT	p.I1813I	CSMD2_ENST00000373377.1_5'UTR|CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Silent_p.I686I	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1773	CUB 11.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGAGGCACTCGATCTCTGGCG	0.657000													27	66					0	0	1	0	0
LRRC58	116064	broad.mit.edu	37	3	120053973	120053973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120053973G>A	ENST00000295628.3	-	3	738	c.643C>T	c.(643-645)Cgt>Tgt	p.R215C		NM_001099678.1	NP_001093148.1	Q96CX6	LRC58_HUMAN	leucine rich repeat containing 58	215										large_intestine(2)|lung(5)	7				GBM - Glioblastoma multiforme(114;0.147)		CTTAGGGAACGAAGTGAATGT	0.343000													15	51					0	0	1	0	0
C16orf46	123775	broad.mit.edu	37	16	81095509	81095509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81095509C>T	ENST00000378611.4	-	3	560	c.445G>A	c.(445-447)Gac>Aac	p.D149N	C16orf46_ENST00000299578.5_Missense_Mutation_p.D149N|RP11-303E16.8_ENST00000564536.1_RNA|C16orf46_ENST00000444657.3_5'UTR	NM_001100873.1	NP_001094343.1	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46	149										NS(1)|endometrium(2)|large_intestine(3)|lung(9)|prostate(1)|stomach(1)|urinary_tract(1)	18						AAGCAGATGTCGCTAATTGCC	0.557000													55	229					0	0	1	0	0
TMEM9	252839	broad.mit.edu	37	1	201115881	201115881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201115881G>A	ENST00000367330.1	-	3	770	c.254C>T	c.(253-255)aCc>aTc	p.T85I	TMEM9_ENST00000367333.1_Missense_Mutation_p.T88I|TMEM9_ENST00000367334.5_Missense_Mutation_p.T85I|TMEM9_ENST00000367329.1_Missense_Mutation_p.T85I|TMEM9_ENST00000367332.1_Missense_Mutation_p.T88I			Q9P0T7	TMEM9_HUMAN	transmembrane protein 9	85					transport	integral to membrane|late endosome membrane|lysosomal membrane				liver(1)|lung(1)|stomach(1)	3		Breast(1374;0.000301)				GATGGTGGTGGTGCTGCGCTC	0.592000													18	97					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823763	38823763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38823763G>A	ENST00000303592.3	-	2	633	c.375C>T	c.(373-375)ttC>ttT	p.F125F		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	125					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					CCGAGAACAGGAAGGCACCCA	0.697000													30	99					0	0	1	0	0
C4orf26	152816	broad.mit.edu	37	4	76489459	76489459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76489459C>T	ENST00000311623.4	+	2	238	c.203C>T	c.(202-204)cCc>cTc	p.P68L	C4orf26_ENST00000435974.2_Missense_Mutation_p.P83S	NM_001257072.1|NM_178497.3	NP_001244001.1|NP_848592.2	Q17RF5	CD026_HUMAN	chromosome 4 open reading frame 26	68						extracellular region				kidney(1)|large_intestine(4)|stomach(1)	6			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ACAAAGACACCCAGGTGTCCC	0.522000													31	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073656	9073656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9073656G>A	ENST00000397910.4	-	3	13993	c.13790C>T	c.(13789-13791)tCc>tTc	p.S4597F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4599	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTCAGGGAGGATGTTGGCTC	0.512000													19	36					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222037	140222037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140222037C>T	ENST00000531613.1	+	1	1131	c.1131C>T	c.(1129-1131)ctC>ctT	p.L377L	PCDHA8_ENST00000378123.3_Silent_p.L377L|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACGACCTCGATTCAGGTG	0.517000													53	112					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4861673	4861673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4861673G>A	ENST00000321919.9	-	14	1489	c.1413C>T	c.(1411-1413)atC>atT	p.I471I	GLYR1_ENST00000381983.3_Silent_p.I454I|GLYR1_ENST00000436648.5_Silent_p.I390I|GLYR1_ENST00000591451.1_Silent_p.I465I	NM_032569.3	NP_115958.2	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	471					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						CCTGATTGAGGATGTCCAAGA	0.542000													8	35					0	0	1	0	0
MED9	55090	broad.mit.edu	37	17	17394729	17394729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:17394729C>T	ENST00000268711.3	+	2	417	c.361C>T	c.(361-363)Ctc>Ttc	p.L121F		NM_018019.2	NP_060489.1	Q9NWA0	MED9_HUMAN	mediator complex subunit 9	121					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GCTGCAGAGCCTCCGGGAGCA	0.557000													30	53					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31532917	31532917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31532917G>A	ENST00000215885.3	-	5	1428	c.1176C>T	c.(1174-1176)ctC>ctT	p.L392L		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	392					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						TGCAGTGGAAGAGGGGCTCTT	0.687000													6	19					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171494075	171494075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171494075C>T	ENST00000367742.3	+	10	1413	c.1171C>T	c.(1171-1173)Ccc>Tcc	p.P391S	PRRC2C_ENST00000476522.1_3'UTR|PRRC2C_ENST00000426496.2_Missense_Mutation_p.P389S|PRRC2C_ENST00000338920.4_Missense_Mutation_p.P389S|PRRC2C_ENST00000392078.3_Missense_Mutation_p.P391S			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	389							protein C-terminus binding										AGCAAAAGTTCCCTATGGGAA	0.373000													8	30					0	0	1	0	0
MS4A2	2206	broad.mit.edu	37	11	59857212	59857212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59857212C>T	ENST00000278888.3	+	2	206	c.104C>T	c.(103-105)tCa>tTa	p.S35L		NM_000139.4	NP_000130.1	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member 2	35					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			endometrium(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)	17		all_epithelial(135;0.245)			Omalizumab(DB00043)	GAAGTATCTTCAGGCAGACTA	0.468000													36	77					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31572557	31572557	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31572557G>A	ENST00000379416.3	-	26	3012	c.2964C>T	c.(2962-2964)ttC>ttT	p.F988F		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	988					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTTACTTGTTGAACTTGTCAA	0.458000													57	121					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121358776	121358776	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121358776G>A	ENST00000260197.7	+	4	693	c.564G>A	c.(562-564)tgG>tgA	p.W188*	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	188					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGTACCTCTGGATCACGTTTG	0.517000													133	335					0	0	1	0	0
RAB25	57111	broad.mit.edu	37	1	156038175	156038175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156038175C>T	ENST00000361084.5	+	3	595	c.354C>T	c.(352-354)atC>atT	p.I118I	RAB25_ENST00000487325.1_3'UTR	NM_020387.2	NP_065120.2	P57735	RAB25_HUMAN	RAB25, member RAS oncogene family	118					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	Hepatocellular(266;0.158)|all_neural(408;0.195)					AAGCCACGATCGTCGTCATGC	0.592000													22	91					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21563423	21563423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:21563423G>A	ENST00000382592.4	-	4	901	c.496C>T	c.(496-498)Cca>Tca	p.P166S	LATS2_ENST00000542899.1_Missense_Mutation_p.P166S|LATS2_ENST00000472754.1_5'UTR	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	166					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CGCGTCACTGGGGTTGGCATG	0.607000													22	47					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48506595	48506595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48506595G>A	ENST00000435803.1	+	44	12882	c.12858G>A	c.(12856-12858)cgG>cgA	p.R4286R	ABCA13_ENST00000544596.1_Intron	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4286					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGCTTCTGCGGAAGTTTAGAG	0.478000													28	90					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53945699	53945699	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53945699C>T	ENST00000454407.1	+	0	55				TPM3P9_ENST00000424846.3_RNA			Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		TACTGATAATCTCAAGGAGGC	0.423000													15	53					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70260694	70260694	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70260694C>T	ENST00000301843.8	+	6	544	c.338C>T	c.(337-339)tCg>tTg	p.S113L	CTTN_ENST00000346329.3_Missense_Mutation_p.S113L|CTTN_ENST00000376561.3_Missense_Mutation_p.S113L	NM_005231.3	NP_005222.2	Q14247	SRC8_HUMAN	cortactin	113						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		AAGCACTGCTCGCAGGTGGAC	0.552000													28	97					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57761237	57761237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57761237G>A	ENST00000360716.3	+	16	2333	c.2112G>A	c.(2110-2112)gaG>gaA	p.E704E	CCDC135_ENST00000394337.4_Silent_p.E704E|CCDC135_ENST00000336825.8_Silent_p.E639E			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	704						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						AGCTTCGAGAGGAAGAGGAGG	0.547000													8	140					0	0	1	0	0
NR4A3	8013	broad.mit.edu	37	9	102607113	102607113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:102607113C>T	ENST00000330847.1	+	5	1514	c.1470C>T	c.(1468-1470)gtC>gtT	p.V490V	NR4A3_ENST00000395097.2_Silent_p.V479V			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	479	Ligand-binding (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				AGCTGTTTGTCCTCAGACTTT	0.393000			T	EWSR1	extraskeletal myxoid chondrosarcoma								16	36					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87757920	87757920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87757920C>T	ENST00000398204.4	+	9	1005	c.682C>T	c.(682-684)Cgt>Tgt	p.R228C	ADAM22_ENST00000398209.3_Missense_Mutation_p.R228C|ADAM22_ENST00000265727.7_Missense_Mutation_p.R228C|ADAM22_ENST00000398201.4_Missense_Mutation_p.R228C|ADAM22_ENST00000439864.1_Missense_Mutation_p.R228C|ADAM22_ENST00000315984.7_Missense_Mutation_p.R228C	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	228					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GTTACAGCTTCGTCGATATCC	0.368000													38	80					0	0	1	0	0
TCL1A	8115	broad.mit.edu	37	14	96178115	96178115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96178115G>A	ENST00000402399.1	-	3	451	c.322C>T	c.(322-324)Ctc>Ttc	p.L108F	TCL1A_ENST00000556450.1_Missense_Mutation_p.L108F|TCL1A_ENST00000555202.1_Missense_Mutation_p.L108F|TCL1A_ENST00000554012.1_Missense_Mutation_p.L108F|RP11-164H13.1_ENST00000553445.1_RNA|RP11-164H13.1_ENST00000547644.2_RNA	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	108					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		AGCAGCTCGAGAAGCATGTCC	0.562000			T	TRA@	T-CLL								8	19					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209452	140209452	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140209452G>A	ENST00000529310.1	+	1	1890	c.1776G>A	c.(1774-1776)gcG>gcA	p.A592A	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGTGGTGGCGAAGGTGCGCG	0.687000													27	97					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6422908	6422908	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6422908G>A	ENST00000449001.2	+	2	650	c.156G>A	c.(154-156)ggG>ggA	p.G52G	PLEKHG6_ENST00000011684.7_Silent_p.G84G|PLEKHG6_ENST00000536531.1_Silent_p.G84G|PLEKHG6_ENST00000396988.3_Silent_p.G84G	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	84					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						AGAGGCACGGGGGCCATGTGG	0.642000													7	61					0	0	1	0	0
ABCA11P	79963	broad.mit.edu	37	4	420330	420330	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:420330G>A	ENST00000451020.2	-	0	708					NR_002451.2																						CAGTACCCAAGAACTTGAGGC	0.488000													31	77					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60366656	60366656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60366656G>A	ENST00000371204.3	-	8	1354	c.1311C>T	c.(1309-1311)gcC>gcT	p.A437A	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	437					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					AAGGCATAAAGGCTTCCCTTT	0.522000													10	84					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23893247	23893247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23893247C>T	ENST00000355349.3	-	23	2953	c.2791G>A	c.(2791-2793)Gag>Aag	p.E931K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	931			E -> K (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCATTCATCTCCTCCTCATCC	0.527000													37	137					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22890774	22890774	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22890774C>T	ENST00000543184.1	-	5	2107	c.1245G>A	c.(1243-1245)ggG>ggA	p.G415G	PRAME_ENST00000402697.1_Silent_p.G415G|PRAME_ENST00000539862.1_Silent_p.G399G|PRAME_ENST00000405655.3_Silent_p.G415G|PRAME_ENST00000424204.2_Silent_p.G399G|PRAME_ENST00000398743.2_Silent_p.G415G|PRAME_ENST00000398741.1_Silent_p.G415G	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	415					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		AGATGGAATTCCCGTAGAAGC	0.547000													16	50					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116692388	116692388	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:116692388C>T	ENST00000357780.3	-	3	500	c.386G>A	c.(385-387)cGa>cAa	p.R129Q		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		ctgaagctctcgcaggttgtc	0.662000													3	12					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284432	159284432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159284432G>A	ENST00000332217.5	-	1	17	c.18C>T	c.(16-18)tcC>tcT	p.S6S		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					TCACAAAAGTGGAATTTAGCT	0.438000													65	162					0	0	1	0	0
ACO1	48	broad.mit.edu	37	9	32405519	32405519	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32405519C>T	ENST00000379923.1	+	3	221	c.15C>T	c.(13-15)ttC>ttT	p.F5F	ACO1_ENST00000541043.1_5'UTR|ACO1_ENST00000309951.5_Silent_p.F5F	NM_001278352.1	NP_001265281.1	P21399	ACOC_HUMAN	aconitase 1, soluble	5					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding	p.F5F(1)		breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		GCAACCCATTCGCACACCTTG	0.398000													13	55					0	0	1	0	0
NPM2	10361	broad.mit.edu	37	8	21891760	21891760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:21891760C>T	ENST00000397940.1	+	6	1520	c.505C>T	c.(505-507)Ccc>Tcc	p.P169S	NPM2_ENST00000518119.1_Missense_Mutation_p.P169S|NPM2_ENST00000289820.6_Missense_Mutation_p.P169S|NPM2_ENST00000381530.5_Intron|NPM2_ENST00000521157.1_Missense_Mutation_p.P169S			Q86SE8	NPM2_HUMAN	nucleophosmin/nucleoplasmin 2	169					chromatin remodeling|embryo development|oocyte differentiation|positive regulation of meiosis|regulation of exit from mitosis|single fertilization	cytoplasmic chromatin|nuclear chromatin	histone binding|nucleic acid binding			large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		AAGGCTGGTGCCCCAGAAGCA	0.562000													22	42					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833793	61833793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61833793G>A	ENST00000280772.1	-	37	7037	c.6846C>T	c.(6844-6846)tcC>tcT	p.S2282S	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2282					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GATCCCGCCCGGACTGAAAGG	0.498000													14	189					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121414256	121414256	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121414256G>A	ENST00000260197.7	+	13	1814		c.e13-1		SORL1_ENST00000532451.1_Splice_Site	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing						cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CATTTGGGCAGATACAGTACC	0.473000													32	93					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45459065	45459065	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45459065C>T	ENST00000548424.1	+	0	448																											TCGTTTCCTTCCTTGAGAATC	0.468000													14	27					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26204076	26204076	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26204076G>A	ENST00000264712.3	-	1	1290	c.711C>T	c.(709-711)atC>atT	p.I237I	KIF3C_ENST00000405914.1_Silent_p.I237I	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	237	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCCCACTCGGATGTGGTCCT	0.627000													27	47					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31322871	31322871	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31322871G>A	ENST00000269197.5	+	12	3059	c.3059G>A	c.(3058-3060)gGg>gAg	p.G1020E		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1020					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TCCAAAATTGGGCCACCTTTT	0.453000													7	36					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45388060	45388060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45388060G>A	ENST00000389039.6	-	30	4431	c.4046C>T	c.(4045-4047)tCc>tTc	p.S1349F	DUOX2_ENST00000603300.1_Missense_Mutation_p.S1349F			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1349	FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GCCCTTTGGGGATGAGTAGAT	0.632000													7	47					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131792787	131792787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131792787G>A	ENST00000286355.5	-	18	5697	c.3605C>T	c.(3604-3606)tCc>tTc	p.S1202F	ADCY8_ENST00000377928.3_Missense_Mutation_p.S1071F	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1202					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CCTATTGAGGGACTGGACAAG	0.537000										HNSCC(32;0.087)			43	60					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29231382	29231382	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29231382G>A	ENST00000441381.1	+	0	79																											ACAGGACAGGGGGAAAGTATC	0.478000													52	118					0	0	1	0	0
TMEM198	130612	broad.mit.edu	37	2	220413939	220413939	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220413939G>A	ENST00000344458.2	+	5	1393	c.808G>A	c.(808-810)Gag>Aag	p.E270K	TMEM198_ENST00000373883.3_Missense_Mutation_p.E270K			Q66K66	TM198_HUMAN	transmembrane protein 198	270	Arg-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		AGATCGCAAGGAGAAAAGGCG	0.637000													14	177					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051295	17051295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:17051295C>T	ENST00000418129.2	+	2	544	c.79C>T	c.(79-81)Cgc>Tgc	p.R27C	PLCL2_ENST00000396755.2_Missense_Mutation_p.R27C|PLCL2_ENST00000460467.1_3'UTR|PLCL2_ENST00000432376.1_Missense_Mutation_p.R27C	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	153	Gly-rich.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						CAAAAAGGTTCGCTCCAACTC	0.418000													21	66					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999996	46999996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46999996G>A	ENST00000374314.4	+	1	2071	c.1116G>A	c.(1114-1116)ctG>ctA	p.L372L	GPRIN2_ENST00000374317.1_Silent_p.L372L			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	372										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GGTCCAGCCTGGAGGAGGTGC	0.672000													16	111					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132952778	132952778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:132952778C>T	ENST00000254624.5	+	2	268	c.43C>T	c.(43-45)Cgc>Tgc	p.R15C	EFR3A_ENST00000334503.4_Missense_Mutation_p.R15C|EFR3A_ENST00000519656.1_5'UTR	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	15						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTTGCGTCCTCGCTACAAACG	0.408000													13	13					0	0	1	0	0
WIPF3	644150	broad.mit.edu	37	7	29924036	29924036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:29924036C>T	ENST00000409290.1	+	4	926	c.926C>T	c.(925-927)cCc>cTc	p.P309L	WIPF3_ENST00000409123.1_Missense_Mutation_p.P309L|WIPF3_ENST00000242140.5_Missense_Mutation_p.P309L	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	309								p.P309H(1)		breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						GCTTCTTTGCCCGCGCCCCCT	0.682000													5	7					0	0	1	0	0
C5orf48	389320	broad.mit.edu	37	5	125971753	125971753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:125971753C>T	ENST00000357147.3	+	3	238	c.225C>T	c.(223-225)ggC>ggT	p.G75G		NM_207408.1	NP_997291.1	Q6ZNM6	CE048_HUMAN	chromosome 5 open reading frame 48	75										large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	7						TCCATACTGGCCCTTTAGAAG	0.383000													30	178					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39496022	39496022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39496022C>T	ENST00000265707.5	+	10	911	c.866C>T	c.(865-867)cCt>cTt	p.P289L	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.P265L	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	289	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding	p.P289L(1)|p.P289F(1)		NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			GCAACATTTCCTGGCACTGTA	0.279000													12	59					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	39910311	39910311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39910311G>A	ENST00000350221.3	-	11	1533	c.1324C>T	c.(1324-1326)Ccc>Tcc	p.P442S		NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	442										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		GAAAGCTGGGGGAACACAGGT	0.378000													45	95					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466958	56466958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56466958G>A	ENST00000291971.3	+	3	1605	c.1534G>A	c.(1534-1536)Gaa>Aaa	p.E512K	NLRP8_ENST00000590542.1_Missense_Mutation_p.E512K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	512	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GACTTTTCAGGAATTTTTTGC	0.468000													64	209					0	0	1	0	0
NUTM2D	728130	broad.mit.edu	37	10	89127097	89127097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:89127097C>T	ENST00000412718.1	+	7	2188	c.1642C>T	c.(1642-1644)Cct>Tct	p.P548S						NUT family member 2D																		GTAGGGAGCCCCTTCAGATGC	0.632000													11	26					0	0	1	0	0
DUT	1854	broad.mit.edu	37	15	48624484	48624484	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48624484C>T	ENST00000331200.3	+	2	393	c.300C>T	c.(298-300)ccC>ccT	p.P100P	DUT_ENST00000559540.1_Silent_p.P12P|DUT_ENST00000455976.2_Silent_p.P12P|DUT_ENST00000559935.1_Silent_p.P15P|DUT_ENST00000559416.1_Silent_p.P15P|DUT_ENST00000558813.1_5'UTR	NM_001025248.1|NM_001025249.1	NP_001020419.1|NP_001020420.1	P33316	DUT_HUMAN	deoxyuridine triphosphatase	100			P -> S (in dbSNP:rs28381104).		DNA replication|dUTP metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process	mitochondrion|nucleoplasm	dUTP diphosphatase activity|protein binding			kidney(2)	2		all_lung(180;0.00265)		all cancers(107;2.66e-09)|GBM - Glioblastoma multiforme(94;6.76e-07)		CCATTTCACCCAGTAAGCGGG	0.721000								Modulation of nucleotide pools					10	42					0	0	1	0	0
FIGF	2277	broad.mit.edu	37	X	15376196	15376196	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:15376196G>A	ENST00000297904.3	-	3	850	c.421C>T	c.(421-423)Cga>Tga	p.R141*		NM_004469.4	NP_004460.1	O43915	VEGFD_HUMAN	c-fos induced growth factor (vascular endothelial growth factor D)	141					angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17	Hepatocellular(33;0.183)					CCACCACATCGGAACACGTTC	0.517000													76	70					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53058065	53058065	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53058065C>T	ENST00000359798.4	+	5	2076	c.1896C>T	c.(1894-1896)ttC>ttT	p.F632F		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	632					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		ACACAGCTTTCACGTGGAATT	0.408000													15	72					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104641424	104641424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104641424G>A	ENST00000315264.7	+	11	2260	c.1882G>A	c.(1882-1884)Gac>Aac	p.D628N	KIF26A_ENST00000423312.2_Missense_Mutation_p.D767N			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	767	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCTGGACCCCGACCGCACGCC	0.726000													4	15					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155200508	155200508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155200508C>T	ENST00000460012.1	-	23	3574	c.3217G>A	c.(3217-3219)Ggt>Agt	p.G1073S	PLCH1_ENST00000334686.6_Missense_Mutation_p.G1073S|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000340059.7_Missense_Mutation_p.G1111S|PLCH1_ENST00000414191.1_Missense_Mutation_p.G1073S			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1111					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCAGGATTACCCTTTTCCTTG	0.473000													43	91					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55032589	55032589	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55032589G>A	ENST00000417545.2	+	2	344	c.258G>A	c.(256-258)ttG>ttA	p.L86L		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	70						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ACATTCGATTGAAGAAGATGG	0.438000													29	26					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23191528	23191528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23191528G>A	ENST00000400191.3	+	5	1144	c.1126G>A	c.(1126-1128)Ggg>Agg	p.G376R	EPHB2_ENST00000374627.1_Missense_Mutation_p.G370R|EPHB2_ENST00000465676.1_3'UTR|EPHB2_ENST00000544305.1_Missense_Mutation_p.G376R|EPHB2_ENST00000374630.3_Missense_Mutation_p.G376R|EPHB2_ENST00000374632.3_Missense_Mutation_p.G376R	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	376	Fibronectin type-III 1.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CACCCGCTGCGGGGACAATGT	0.637000													39	85					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13695737	13695737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:13695737G>A	ENST00000202816.1	-	14	2447	c.2340C>T	c.(2338-2340)ttC>ttT	p.F780F		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	780	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TTGTTTTCTTGAAATTGGGAT	0.388000													42	106					0	0	1	0	0
KDM3A	55818	broad.mit.edu	37	2	86678279	86678279	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:86678279C>T	ENST00000409556.1	+	5	761	c.396C>T	c.(394-396)cgC>cgT	p.R132R	KDM3A_ENST00000542128.1_Silent_p.R80R|KDM3A_ENST00000409064.1_Silent_p.R132R|KDM3A_ENST00000312912.5_Silent_p.R132R			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	132					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						CTTCTGTTCGCTTTCTGGGAG	0.358000													30	72					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158618317	158618317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158618317G>A	ENST00000368148.3	-	26	3876	c.3696C>T	c.(3694-3696)ctC>ctT	p.L1232L	SPTA1_ENST00000368147.3_Silent_p.L1232L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1232					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCAGGGGTACGAGGTCCCTTT	0.498000													56	51					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10466660	10466660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10466660C>T	ENST00000382483.3	-	4	5171	c.4948G>A	c.(4948-4950)Gag>Aag	p.E1650K		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1650					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCCTCCGCCTCCTCGCCCAGC	0.677000													15	49					0	0	1	0	0
IFNL1	282618	broad.mit.edu	37	19	39787205	39787205	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39787205G>A	ENST00000333625.2	+	1	241	c.144G>A	c.(142-144)gcG>gcA	p.A48A		NM_172140.1	NP_742152.1			interferon, lambda 1																		AGGAGCTAGCGAGCTTCAAGA	0.582000													11	27					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107417675	107417675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107417675C>T	ENST00000334504.7	-	31	3366	c.3133G>A	c.(3133-3135)Gaa>Aaa	p.E1045K	COL4A6_ENST00000372216.4_Missense_Mutation_p.E1046K|COL4A6_ENST00000545689.1_Missense_Mutation_p.E1045K|COL4A6_ENST00000538570.1_Missense_Mutation_p.E1045K|COL4A6_ENST00000394872.2_Missense_Mutation_p.E1046K	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1046	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						CTTACACTTTCTCCTGGCATT	0.552000									Alport syndrome with Diffuse Leiomyomatosis				18	16					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095033	69095033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69095033C>T	ENST00000332644.5	-	8	1049	c.888G>A	c.(886-888)atG>atA	p.M296I		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	296	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						CTGAGAGCTTCATTTTGGCTT	0.378000													37	80					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64117071	64117071	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64117071G>A	ENST00000356786.5	+	16	2837	c.2793G>A	c.(2791-2793)gcG>gcA	p.A931A	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000359902.2_Silent_p.A83A|CCDC88B_ENST00000301897.4_5'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	931					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGGCGGCGGCGACCAGCAAGG	0.682000													4	13					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7528297	7528297	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7528297G>A	ENST00000313599.3	-	10	2742	c.2686_splice	c.e10+1	p.S895_splice	CD163L1_ENST00000416109.2_Splice_Site_p.S905_splice|CD163L1_ENST00000396630.1_Splice_Site_p.S895_splice|CD163L1_ENST00000544331.1_5'UTR			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	895	SRCR 8.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						AAATCTCACGGGAACAGACAA	0.463000													22	67					0	0	1	0	0
PRKAB2	5565	broad.mit.edu	37	1	146638497	146638497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:146638497G>A	ENST00000254101.3	-	4	483	c.345C>T	c.(343-345)atC>atT	p.I115I	PRKAB2_ENST00000425272.2_Silent_p.I33I	NM_005399.3	NP_005390.1	O43741	AAKB2_HUMAN	protein kinase, AMP-activated, beta 2 non-catalytic subunit	115					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				NS(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	GGAGGTCCAGGATGGCAACAA	0.438000													9	43					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29275106	29275106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29275106C>T	ENST00000377160.2	+	1	704	c.640C>T	c.(640-642)Ctc>Ttc	p.L214F		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						CTCCATTGTGCTCTCCTACAT	0.468000													64	136					0	0	1	0	0
MAOA	4128	broad.mit.edu	37	X	43571145	43571145	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:43571145C>T	ENST00000338702.3	+	4	456	c.333C>T	c.(331-333)gcC>gcT	p.A111A	MAOA_ENST00000497485.1_3'UTR|MAOA_ENST00000542639.1_5'UTR	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	111					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	TTCGGGGCGCCTTTCCACCAG	0.363000													38	43					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1367606	1367606	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:1367606T>G	ENST00000446702.2	+	9	1681	c.1054T>G	c.(1054-1056)Tta>Gta	p.L352V	CNTN6_ENST00000539053.1_Missense_Mutation_p.L280V|CNTN6_ENST00000350110.2_Missense_Mutation_p.L352V			Q9UQ52	CNTN6_HUMAN	contactin 6	352	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GTATACATGGTTAAAAAATGG	0.363000													34	58					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322672	55322672	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55322672T>C	ENST00000314644.2	+	1	890	c.890T>C	c.(889-891)aTt>aCt	p.I297T		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GGATCTCACATTGCTGTTGTG	0.433000										HNSCC(20;0.049)			46	151					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69798419	69798419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69798419C>T	ENST00000251566.4	-	3	953	c.923G>A	c.(922-924)gGg>gAg	p.G308E	UGT2A3_ENST00000420231.2_Missense_Mutation_p.G19E	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	308						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AAACAGTGACCCCAGAGAAAA	0.388000													52	200					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278576	36278576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36278576C>T	ENST00000007510.4	+	21	3253	c.3109C>T	c.(3109-3111)Ccc>Tcc	p.P1037S	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.P873S|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.P876S			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1037					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CTCCCCAGCCCCCAGGGAGTG	0.697000													49	89					0	0	1	0	0
TMPPE	643853	broad.mit.edu	37	3	33134649	33134649	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33134649G>A	ENST00000342462.4	-	2	1229	c.1039C>T	c.(1039-1041)Cat>Tat	p.H347Y	GLB1_ENST00000399402.3_Intron|GLB1_ENST00000307377.8_Intron|GLB1_ENST00000445488.2_Intron|TMPPE_ENST00000416695.2_Missense_Mutation_p.H210Y|GLB1_ENST00000307363.5_Intron	NM_001039770.2	NP_001034859.2	Q6ZT21	TMPPE_HUMAN	transmembrane protein with metallophosphoesterase domain	347				H -> R (in Ref. 1; BAC87349).		integral to membrane	metal ion binding			breast(1)|large_intestine(5)|lung(6)|prostate(1)	13						TCCATGCCATGGCCAGAGTAG	0.592000													39	131					0	0	1	0	0
PTF1A	256297	broad.mit.edu	37	10	23482809	23482809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:23482809G>A	ENST00000376504.3	+	2	1165	c.961G>A	c.(961-963)Gaa>Aaa	p.E321K		NM_178161.2	NP_835455.1	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	321					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						CATAGAAAACGAACCACCATT	0.398000													38	132					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082626	9082626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9082626C>T	ENST00000397910.4	-	1	9392	c.9189G>A	c.(9187-9189)agG>agA	p.R3063R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3064	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTTGGGCTGCCTTGCCATGG	0.483000													44	129					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163279938	163279938	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163279938G>A	ENST00000332142.5	-	9	2161	c.2062C>T	c.(2062-2064)Cgc>Tgc	p.R688C	KCNH7_ENST00000328032.4_Missense_Mutation_p.R681C	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	688					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGGTGAAAGCGAATGAACTCT	0.438000													26	189					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31709925	31709925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31709925G>A	ENST00000261592.5	-	2	621	c.324C>T	c.(322-324)ttC>ttT	p.F108F	NOL4_ENST00000269185.4_5'UTR|NOL4_ENST00000535475.1_5'UTR|NOL4_ENST00000589544.1_Silent_p.F108F|NOL4_ENST00000538587.1_Silent_p.F34F	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	108						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TAATGTCAAAGAAATCTTCAA	0.393000													30	81					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41743987	41743987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41743987C>T	ENST00000301178.4	+	7	1112	c.922C>T	c.(922-924)Cgc>Tgc	p.R308C	AXL_ENST00000593513.1_Missense_Mutation_p.R40C|AXL_ENST00000359092.3_Missense_Mutation_p.R308C	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	308	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						TTATCACATCCGCGTGGCATG	0.647000													51	151					0	0	1	0	0
LYNX1	66004	broad.mit.edu	37	8	143846155	143846155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143846155G>A	ENST00000335822.5	-	5	891	c.264C>T	c.(262-264)gtC>gtT	p.V88V	LYNX1_ENST00000523332.1_Intron|RP11-706C16.7_ENST00000523657.1_RNA|LYNX1_ENST00000317543.7_Silent_p.V54V	NM_023946.2	NP_076435.1	Q86SR0	SLUR2_HUMAN	Ly6/neurotoxin 1	54	UPAR/Ly6.					extracellular region				endometrium(1)|lung(2)|skin(1)	4	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGTTGCTGAGGACCCCTGAGT	0.622000													20	43					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17104380	17104380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17104380G>A	ENST00000443236.1	-	12	1284	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	CPAMD8_ENST00000388925.4_Missense_Mutation_p.P371L	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	371						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GCTGCCATCGGGGTAGGATAG	0.532000													15	55					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73662134	73662134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73662134C>T	ENST00000339764.1	+	1	771	c.20C>T	c.(19-21)tCt>tTt	p.S7F		NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	7	J.				apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					GATTATTACTCTGTGCTCGGG	0.587000													15	26					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409675	59409675	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:59409675G>A	ENST00000301645.3	-	3	533	c.396C>T	c.(394-396)acC>acT	p.T132T		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	132					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GGCCCTGCAGGGTTTTGATGA	0.458000									Neonatal Giant Cell Hepatitis				36	89					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821097	43821097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43821097C>T	ENST00000417669.1	+	2	550	c.106C>T	c.(106-108)Cgg>Tgg	p.R36W	MPPED1_ENST00000443721.1_Missense_Mutation_p.R36W|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000542779.1_Missense_Mutation_p.R36W|MPPED1_ENST00000538182.1_Missense_Mutation_p.R69W			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	36							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				GATGGCCGCTCGGCGGCACCA	0.662000													23	36					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46656397	46656397	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46656397C>T	ENST00000544460.1	+	1	786	c.532C>T	c.(532-534)Cgc>Tgc	p.R178C	TDRD6_ENST00000316081.6_Missense_Mutation_p.R178C	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	178					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding	p.R178C(1)		NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GCTGCTCCATCGCCTGGTCCT	0.682000													22	75					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68950480	68950480	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68950480G>T	ENST00000288368.4	+	7	1069	c.792G>T	c.(790-792)gtG>gtT	p.V264V	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	264	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AAGAACGGGTGTTTTTTCTTT	0.403000													26	54					2.41591e-17	2.42983e-17	1	1	0
ZBTB7C	201501	broad.mit.edu	37	18	45566511	45566511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:45566511C>T	ENST00000588982.1	-	3	1469	c.968G>A	c.(967-969)gGa>gAa	p.G323E	ZBTB7C_ENST00000586438.1_Missense_Mutation_p.G323E|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.G323E|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.G323E|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.G323E			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	323	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CTTGATGGGTCCCAGAGGCCC	0.632000													29	71					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149260061	149260061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:149260061C>T	ENST00000407073.1	+	13	5317	c.4320C>T	c.(4318-4320)gtC>gtT	p.V1440V	MBD5_ENST00000404807.1_Silent_p.V1673V	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1440	PWWP.					chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ACAGCCGTGTCCGGAAAAGGA	0.408000													9	41					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40433119	40433119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40433119C>T	ENST00000221347.6	-	2	1157	c.1150G>A	c.(1150-1152)Gag>Aag	p.E384K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	384	IgGFc-binding.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCACAGCCTCCCAGGTGAGC	0.617000													25	47					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161139349	161139349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161139349C>T	ENST00000308192.9	+	8	874	c.811C>T	c.(811-813)Ccc>Tcc	p.P271S		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	271					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATCTTCTGGTCCCACCTACCA	0.512000													43	55					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508751	37508751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37508751G>A	ENST00000374660.1	+	40	4399	c.4300G>A	c.(4300-4302)Gag>Aag	p.E1434K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1315K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1315K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1371						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AGAGAAAAATGAGGAGATATT	0.269000													7	22					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123759877	123759877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123759877G>A	ENST00000223642.1	-	21	2767	c.2738C>T	c.(2737-2739)tCa>tTa	p.S913L		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	913					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	AGTCTCCAGTGAAAAATTGAT	0.393000													14	71					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78210729	78210729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78210729C>T	ENST00000361193.3	+	8	1019	c.739C>T	c.(739-741)Cgc>Tgc	p.R247C	SLC26A11_ENST00000411502.3_Missense_Mutation_p.R247C|SLC26A11_ENST00000572725.1_Missense_Mutation_p.R247C|SLC26A11_ENST00000546047.2_Missense_Mutation_p.R247C	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	247						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TCTCCTAGCTCGCAACGCCCT	0.632000													71	166					0	0	1	0	0
COA6	388753	broad.mit.edu	37	1	234509379	234509379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:234509379C>T	ENST00000366615.4	+	1	178	c.167C>T	c.(166-168)tCc>tTc	p.S56F		NM_001206641.1	NP_001193570.1			cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)																		GTGACAGTTTCCTCCCGTCGA	0.687000													17	153					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902233	51902233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:51902233G>A	ENST00000268919.4	+	1	1995	c.1839G>A	c.(1837-1839)ggG>ggA	p.G613G		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	613					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CAATTTCAGGGAAGGGATCTA	0.423000													25	95					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113538213	113538213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113538213C>T	ENST00000416899.2	+	9	1456	c.1330C>T	c.(1330-1332)Ccc>Tcc	p.P444S	MUSK_ENST00000189978.5_Missense_Mutation_p.P444S|MUSK_ENST00000374438.1_Missense_Mutation_p.P35L|MUSK_ENST00000374448.4_Missense_Mutation_p.P444S			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	444	FZ.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						GCATTGGGACCCCACGGCCTG	0.488000													14	210					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81657081	81657081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81657081G>A	ENST00000550584.2	-	30	3939	c.3644C>T	c.(3643-3645)tCc>tTc	p.S1215F	PPFIA2_ENST00000333447.7_Missense_Mutation_p.S1203F|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Missense_Mutation_p.S1200F|PPFIA2_ENST00000541570.2_Missense_Mutation_p.S751F|PPFIA2_ENST00000541017.1_Missense_Mutation_p.S401F|PPFIA2_ENST00000552948.1_Missense_Mutation_p.S1194F|PPFIA2_ENST00000548586.1_Missense_Mutation_p.S1209F|PPFIA2_ENST00000407050.4_Missense_Mutation_p.S1114F|PPFIA2_ENST00000550359.2_Missense_Mutation_p.S1062F|PPFIA2_ENST00000443686.3_Missense_Mutation_p.S1110F|PPFIA2_ENST00000549396.1_Missense_Mutation_p.S1215F	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	1114										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TGTTTCTGAGGACCCAGGCAT	0.458000													12	21					0	0	1	0	0
ACOX1	51	broad.mit.edu	37	17	73949573	73949573	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73949573G>A	ENST00000537812.1	-	7	1437	c.789C>T	c.(787-789)atC>atT	p.I263I	ACOX1_ENST00000301608.4_Silent_p.I301I|ACOX1_ENST00000293217.5_Silent_p.I301I	NM_001185039.1	NP_001171968.1	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	301					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						CGCTGTATCGGATGGCAATGG	0.532000													22	65					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76073015	76073015	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:76073015G>A	ENST00000395215.3	+	0	404																											AAGCACAGATGGAGCAGTTAG	0.473000													16	123					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50249977	50249977	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50249977C>T	ENST00000246801.3	-	6	824	c.742G>A	c.(742-744)Gag>Aag	p.E248K	TSKS_ENST00000358830.3_Missense_Mutation_p.E48K	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	248							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		tcctgcttctcctccggctcc	0.697000													7	15					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111409812	111409812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111409812G>A	ENST00000265162.5	+	2	1102	c.760G>A	c.(760-762)Gga>Aga	p.G254R		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	254					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CAAAGAATACGGAGCACTTTC	0.383000													28	70					0	0	1	0	0
ZNF490	57474	broad.mit.edu	37	19	12692196	12692196	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12692196G>A	ENST00000311437.6	-	5	815	c.693C>T	c.(691-693)ttC>ttT	p.F231F		NM_020714.2	NP_065765.1	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	18						AGAGAAATGCGAAGGCTTTGC	0.423000													42	83					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95549901	95549901	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95549901C>T	ENST00000371418.4	+	5	737	c.477C>T	c.(475-477)ttC>ttT	p.F159F	LGI1_ENST00000371413.3_Silent_p.F159F|LGI1_ENST00000542308.1_Silent_p.F111F	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	159					axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				AAGATATTTTCAAAGGCCTGG	0.333000													24	64					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12954498	12954498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12954498G>A	ENST00000235347.4	-	3	864	c.785C>T	c.(784-786)cCa>cTa	p.P262L		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	262										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGAGGAATGGAGAGTCCAA	0.473000													23	286					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12313762	12313762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12313762C>T	ENST00000256186.2	+	2	338	c.47C>T	c.(46-48)tCg>tTg	p.S16L		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	16	Ser-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cttccttcatcgtcttcccat	0.493000													15	44					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370099	240370099	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240370099G>A	ENST00000319653.9	+	5	2217	c.1986_splice	c.e5-1	p.E663_splice		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	663					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.E806K(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CGCCCTTCAGGAAGTTGTTGA	0.393000													9	38					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479935	4479935	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4479935C>T	ENST00000237837.1	-	3	475	c.330G>A	c.(328-330)ccG>ccA	p.P110P		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	110					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity	p.P110P(1)		NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			TGCAGTTCTCCGGGTCGAAAT	0.607000													15	85					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458788	248458788	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248458788G>A	ENST00000317996.1	-	1	92	c.93C>T	c.(91-93)gcC>gcT	p.A31A		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			TCAAAACGGTGGCCAGAAGCA	0.493000													19	176					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169141143	169141143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169141143G>A	ENST00000256935.8	+	18	1851	c.1771G>A	c.(1771-1773)Ggg>Agg	p.G591R	DOCK2_ENST00000520908.1_Missense_Mutation_p.G83R|DOCK2_ENST00000540750.1_5'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	591	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGTGTTGGGGGGCTTTCTGT	0.547000													22	49					0	0	1	0	0
ATP8B5P	158381	broad.mit.edu	37	9	35449850	35449850	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35449850G>A	ENST00000430846.1	+	0	2700																											ATGCTATAAAGAACATCTTCA	0.423000													10	34					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600303	92600303	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92600303G>T	ENST00000298047.6	+	21	12072	c.12055G>T	c.(12055-12057)Gtg>Ttg	p.V4019L	FAT3_ENST00000533797.1_Missense_Mutation_p.V354L|FAT3_ENST00000409404.2_Missense_Mutation_p.V4019L|FAT3_ENST00000525166.1_Missense_Mutation_p.V3869L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4019					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTGGGCTGCGTGCTCTATCC	0.657000										TCGA Ovarian(4;0.039)			3	3					0.115264	0.115276	1	1	0
PCDH9	5101	broad.mit.edu	37	13	67205501	67205501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:67205501C>T	ENST00000544246.1	-	4	3872	c.3181G>A	c.(3181-3183)Gaa>Aaa	p.E1061K	PCDH9_ENST00000377865.2_Missense_Mutation_p.E1061K|PCDH9_ENST00000456367.1_Missense_Mutation_p.E1027K|PCDH9_ENST00000328454.5_Missense_Mutation_p.E1027K	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1061					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CTGCAGCTTTCCTGGGAGCCA	0.517000													27	40					0	0	1	0	0
PMPCA	23203	broad.mit.edu	37	9	139313499	139313499	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139313499C>T	ENST00000371717.3	+	11	1213	c.1204C>T	c.(1204-1206)Cga>Tga	p.R402*	PMPCA_ENST00000399219.3_Nonsense_Mutation_p.R271*|PMPCA_ENST00000462616.1_3'UTR	NM_015160.1	NP_055975.1	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	402					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|urinary_tract(1)	14		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		TTCGCAGGTTCGAGAAATGGT	0.567000													18	96					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78340139	78340139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78340139C>T	ENST00000255189.3	-	6	1010	c.982G>A	c.(982-984)Gga>Aga	p.G328R	DMGDH_ENST00000540686.1_Intron|DMGDH_ENST00000380311.4_Missense_Mutation_p.G127R	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	328					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		GGAGGAACTCCATTGGTGACC	0.458000													41	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9000453	9000453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9000453G>A	ENST00000397910.4	-	54	40734	c.40531C>T	c.(40531-40533)Ctt>Ttt	p.L13511F	MUC16_ENST00000380951.5_Missense_Mutation_p.L152F	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13513	SEA 10.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGACCCTGAAGGACTCTCTCC	0.488000													21	75					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3788206	3788206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:3788206G>A	ENST00000440314.2	-	6	872	c.399C>T	c.(397-399)gcC>gcT	p.A133A	EFCAB4B_ENST00000444507.1_Silent_p.A133A|EFCAB4B_ENST00000252322.1_Silent_p.A133A	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	133					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			CATGGCGCTGGGCCACCTGTT	0.557000													15	95					0	0	1	0	0
OR4D6	219983	broad.mit.edu	37	11	59224523	59224523	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59224523C>T	ENST00000300127.2	+	1	113	c.90C>T	c.(88-90)gtC>gtT	p.V30V		NM_001004708.1	NP_001004708.1	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D, member 6	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	34						TGTTTGTGGTCTTCTTTGCTG	0.463000													41	120					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	20959375	20959375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20959375G>A	ENST00000298925.5	+	11	1278	c.1125G>A	c.(1123-1125)cgG>cgA	p.R375R	NELL1_ENST00000325319.5_Silent_p.R290R|NELL1_ENST00000532434.1_Silent_p.R347R|NELL1_ENST00000357134.5_Silent_p.R347R			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	347	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						AAGGCCAGCGGATTTTAACCA	0.408000													29	78					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73043525	73043525	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73043525C>T	ENST00000604411.1	+	0	31486				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TTTTCCATCTCCTCAATCAGG	0.408000													42	87					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580471	140580471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580471C>T	ENST00000354757.3	+	1	1124	c.1124C>T	c.(1123-1125)tCt>tTt	p.S375F	PCDHB11_ENST00000536699.1_Missense_Mutation_p.S10F	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		375	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATATAGACTCTGGGGACAAC	0.428000													32	110					0	0	1	0	0
WDR43	23160	broad.mit.edu	37	2	29135488	29135488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29135488C>T	ENST00000407426.3	+	4	574	c.518C>T	c.(517-519)tCc>tTc	p.S173F		NM_015131.1	NP_055946.1	Q15061	WDR43_HUMAN	WD repeat domain 43	173						nucleolus				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	20	Acute lymphoblastic leukemia(172;0.155)					AGTGTCAGTTCCCTATGTATC	0.398000													32	59					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4829654	4829654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4829654G>A	ENST00000354582.6	+	51	6944	c.6594G>A	c.(6592-6594)atG>atA	p.M2198I	ITPR1_ENST00000302640.8_Missense_Mutation_p.M2198I|ITPR1_ENST00000456211.2_Missense_Mutation_p.M2150I|ITPR1_ENST00000423119.2_Missense_Mutation_p.M2165I|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.M2165I|ITPR1_ENST00000443694.2_Missense_Mutation_p.M2198I			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2213					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ACCGAACAATGGAACAGATAG	0.383000													6	20					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55032413	55032413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55032413G>A	ENST00000417545.2	+	2	168	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	12						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						CTTCCAGAGGGAACTCACCTG	0.483000													89	67					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114202624	114202624	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:114202624C>T	ENST00000434316.2	+	12	2136	c.1777C>T	c.(1777-1779)Ctg>Ttg	p.L593L	TMCO3_ENST00000375391.1_Intron	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	593						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GCAGTTTCTCCTGGCGGCGCT	0.557000													18	64					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79693265	79693265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:79693265G>A	ENST00000261205.4	+	8	1401	c.744G>A	c.(742-744)atG>atA	p.M248I	SYT1_ENST00000393240.3_Missense_Mutation_p.M248I|SYT1_ENST00000457153.2_Missense_Mutation_p.M245I|SYT1_ENST00000552744.1_Missense_Mutation_p.M248I	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	248	Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						AAGTCCCTATGAACACAGTGG	0.418000													39	125					0	0	1	0	0
TMEM202	338949	broad.mit.edu	37	15	72698948	72698948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72698948C>T	ENST00000341689.3	+	3	397	c.343C>T	c.(343-345)Ctc>Ttc	p.L115F	TMEM202_ENST00000567679.1_Silent_p.I29I	NM_001080462.1	NP_001073931.1	A6NGA9	TM202_HUMAN	transmembrane protein 202	115						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	18						TGCAGATTATCTCCAATATTC	0.453000													17	123					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28648063	28648063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28648063C>T	ENST00000280904.6	-	16	3067	c.2624G>A	c.(2623-2625)cGa>cAa	p.R875Q	DSC2_ENST00000251081.6_3'UTR	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	875					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTCTTCTTGTCGTTCACTGCA	0.413000													33	79					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762058	92762058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92762058C>T	ENST00000318238.4	-	5	4443	c.3227G>A	c.(3226-3228)aGa>aAa	p.R1076K	SAMD9L_ENST00000411955.1_Missense_Mutation_p.R1076K|SAMD9L_ENST00000437805.1_Missense_Mutation_p.R1076K	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1076										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGGGAATCGTCTACTTCCTGC	0.428000													56	132					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4883992	4883992	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:4883992G>A	ENST00000298375.7	+	7	767	c.696G>A	c.(694-696)ctG>ctA	p.L232L	AKR1E2_ENST00000532248.1_Intron|AKR1E2_ENST00000334019.4_Intron|AKR1E2_ENST00000525281.1_Intron|AKR1E2_ENST00000345253.5_Intron	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	232						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						GGGTTGACCTGATAGACAACC	0.517000													9	23					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809042	18809042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18809042C>T	ENST00000400664.1	+	1	1619	c.1567C>T	c.(1567-1569)Cgc>Tgc	p.R523C		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	523						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCGCTGGCTCGCATGCCCCC	0.672000													38	100					0	0	1	0	0
PKP3	11187	broad.mit.edu	37	11	397183	397183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:397183G>A	ENST00000331563.2	+	3	758	c.682G>A	c.(682-684)Ggg>Agg	p.G228R		NM_007183.2	NP_009114.1	Q9Y446	PKP3_HUMAN	plakophilin 3	228					cell adhesion	desmosome|nucleus	binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGGGCAGGGGGGCTGGACTG	0.711000													21	31					0	0	1	0	0
GPX3	2878	broad.mit.edu	37	5	150404937	150404937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150404937G>A	ENST00000388825.4	+	2	216	c.124G>A	c.(124-126)Gag>Aag	p.E42K	GPX3_ENST00000517973.1_Intron|GPX3_ENST00000521722.1_3'UTR	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	42					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CACCATTTACGAGTACGGAGC	0.512000													26	74					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123504887	123504887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123504887C>T	ENST00000392770.2	-	5	1414	c.612G>A	c.(610-612)gaG>gaA	p.E204E	SCN3B_ENST00000530277.1_Silent_p.E204E|SCN3B_ENST00000299333.3_Silent_p.E204E	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	204					axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		TCTCCTTGTTCTCAGATGGGA	0.537000													18	42					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139629193	139629193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139629193C>T	ENST00000303045.6	-	54	4280	c.3834G>A	c.(3832-3834)aaG>aaA	p.K1278K	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Silent_p.K1258K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1278	Collagen-like 12.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTGTGTGTCCCTTGAAGCCCT	0.587000										HNSCC(7;0.00092)			15	69					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117245	20117245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20117245G>A	ENST00000397165.2	-	4	1226	c.1066C>T	c.(1066-1068)Ctt>Ttt	p.L356F	ZNF682_ENST00000358523.5_Missense_Mutation_p.L324F|ZNF682_ENST00000595736.1_Missense_Mutation_p.L280F|ZNF682_ENST00000596019.1_Intron|ZNF682_ENST00000397162.1_Missense_Mutation_p.L324F|ZNF682_ENST00000597972.1_Missense_Mutation_p.L362F	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	356					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						TGTTCAGTAAGAATTGATGAT	0.368000													21	55					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124352006	124352006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124352006G>A	ENST00000368909.3	+	20	2501	c.2395G>A	c.(2395-2397)Gat>Aat	p.D799N	DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368955.3_Missense_Mutation_p.D789N|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000344338.3_Missense_Mutation_p.D789N|DMBT1_ENST00000338354.3_Missense_Mutation_p.D799N	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	799	SRCR 6.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGTTCTGGATGATGTGCGCTG	0.607000													25	231					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94933697	94933697	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94933697G>A	ENST00000337425.5	-	3	779	c.705C>T	c.(703-705)caC>caT	p.H235H	SERPINA9_ENST00000448305.2_Silent_p.H137H|SERPINA9_ENST00000424550.2_Silent_p.H86H|SERPINA9_ENST00000298845.7_Silent_p.H135H|SERPINA9_ENST00000546329.1_Silent_p.H199H|SERPINA9_ENST00000380365.3_Silent_p.H217H	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	217					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TATATTCAGGGTGAAAGGGCT	0.468000													15	35					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129470130	129470130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:129470130C>T	ENST00000421865.2	+	7	965	c.916C>T	c.(916-918)Cgc>Tgc	p.R306C		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	306	Laminin EGF-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTAGAAATCTCGCTGTGAGTG	0.418000													35	58					0	0	1	0	0
IGHV3-30	28439	broad.mit.edu	37	14	106791008	106791008	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106791008C>T	ENST00000390613.2	-	0	427																											CTGTGTCTCTCGCACAGTAAT	0.562000													73	551					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130934774	130934774	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130934774C>T	ENST00000261655.4	-	6	664	c.501G>A	c.(499-501)ggG>ggA	p.G167G	RIMBP2_ENST00000536002.1_Silent_p.G75G|RIMBP2_ENST00000535703.1_Silent_p.G75G	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	167	SH3 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGTGGACCTTCCCCGAGTATC	0.562000													4	25					0	0	1	0	0
LCE3E	353145	broad.mit.edu	37	1	152538680	152538680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152538680G>A	ENST00000368789.1	-	2	60	c.5C>T	c.(4-6)tCc>tTc	p.S2F		NM_178435.2	NP_848522.1	Q5T5B0	LCE3E_HUMAN	late cornified envelope 3E	2					keratinization					lung(6)|ovary(1)	7	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		Lung(1;0.000294)|LUAD - Lung adenocarcinoma(1;0.00527)|LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)		CTGCTGGCAGGACATCTTGGC	0.542000													23	55					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38156645	38156645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38156645G>A	ENST00000379747.4	-	10	1367	c.1250C>T	c.(1249-1251)aCt>aTt	p.T417I	POSTN_ENST00000379742.4_Missense_Mutation_p.T417I|POSTN_ENST00000541179.1_Missense_Mutation_p.T417I|POSTN_ENST00000379743.4_Missense_Mutation_p.T417I|POSTN_ENST00000379749.4_Missense_Mutation_p.T417I|POSTN_ENST00000541481.1_Missense_Mutation_p.T417I	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	417	FAS1 3.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CATGCTGAGAGTATCATCTGT	0.333000													15	52					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5754219	5754219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5754219C>T	ENST00000381624.3	+	13	1302	c.1241C>T	c.(1240-1242)tCg>tTg	p.S414L	CATSPERD_ENST00000309164.7_3'UTR|CATSPERD_ENST00000381614.2_Missense_Mutation_p.S72L	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	414						integral to membrane											TTGACTGCTTCGTTGATACCC	0.453000													64	138					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53519078	53519078	+	Silent	SNP	G	G	A	rs138040011		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:53519078G>A	ENST00000370905.3	-	2	1133	c.993C>T	c.(991-993)tcC>tcT	p.S331S	KLHL31_ENST00000407079.1_Silent_p.S331S	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					CTCTGCTAAGGGACTTCTCAG	0.488000													41	89					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8486289	8486289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8486289C>T	ENST00000447869.1	-	3	1338	c.420G>A	c.(418-420)acG>acA	p.T140T	STK33_ENST00000358872.3_5'UTR|STK33_ENST00000534493.1_Silent_p.T99T|STK33_ENST00000315204.1_Silent_p.T140T|STK33_ENST00000396673.1_Silent_p.T140T|STK33_ENST00000396672.1_Silent_p.T140T			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	140	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		TTGCCCACTTCGTTTCTGTTT	0.413000													51	84					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153652206	153652206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153652206C>T	ENST00000368680.3	+	1	1094	c.622C>T	c.(622-624)Cgc>Tgc	p.R208C		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	208					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CATGCGGGTCCGCGACCGCCT	0.657000													4	18					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76900452	76900452	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76900452C>T	ENST00000409709.3	+	28	3839	c.3567C>T	c.(3565-3567)gcC>gcT	p.A1189A	MYO7A_ENST00000409619.2_Silent_p.A1178A|MYO7A_ENST00000458637.2_Silent_p.A1189A	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1189	MyTH4 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCAGCTATGCCCGGGGCTGGA	0.622000													29	55					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64595811	64595811	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:64595811C>T	ENST00000536360.1	-	10	2184		c.e10+1					Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		AGATTACTTACTCTAGAAAGC	0.413000													23	57					0	0	1	0	0
STAC3	246329	broad.mit.edu	37	12	57642935	57642935	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57642935C>T	ENST00000332782.2	-	3	424	c.223G>A	c.(223-225)Gag>Aag	p.E75K	STAC3_ENST00000554578.1_Missense_Mutation_p.E36K|STAC3_ENST00000546246.2_Intron	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	75	Poly-Glu.				intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						GGTGGctcctcctcctcctct	0.552000													30	64					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73405711	73405711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73405711G>A	ENST00000224721.6	+	12	1284	c.1279G>A	c.(1279-1281)Gag>Aag	p.E427K	CDH23_ENST00000398809.4_Missense_Mutation_p.E422K|CDH23_ENST00000398842.3_Missense_Mutation_p.E422K|CDH23_ENST00000299366.7_Missense_Mutation_p.E467K|CDH23_ENST00000461841.3_Missense_Mutation_p.E467K	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	422	Cadherin 4.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACTGGACTACGAGACCGTGGA	0.592000													22	50					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160843796	160843796	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160843796G>A	ENST00000283243.7	-	12	2114	c.1908C>T	c.(1906-1908)caC>caT	p.H636H	PLA2R1_ENST00000392771.1_Silent_p.H636H	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	636	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						TTGCCTTAAAGTGCCGACAGT	0.483000													7	40					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83933329	83933329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83933329C>T	ENST00000345382.2	-	4	759	c.674G>A	c.(673-675)gGa>gAa	p.G225E	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.G218E	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	225					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						GCTGGGGTTTCCTTTGTCCAC	0.498000													51	153					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38990558	38990558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38990558G>A	ENST00000355481.4	+	45	7356	c.7225G>A	c.(7225-7227)Gaa>Aaa	p.E2409K	RYR1_ENST00000360985.3_Missense_Mutation_p.E2409K|RYR1_ENST00000359596.3_Missense_Mutation_p.E2409K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2409	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTTTGGTGAGGAACCGCCTGA	0.632000													36	93					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11648272	11648272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11648272C>T	ENST00000262442.3	+	31	6338	c.6270C>T	c.(6268-6270)ttC>ttT	p.F2090F	DNAH9_ENST00000454412.2_Silent_p.F2090F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2090					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCCCATCTTCATGGGCCTGA	0.572000													19	23					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109284406	109284406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109284406G>A	ENST00000370017.3	+	12	2459	c.2182G>A	c.(2182-2184)Ggg>Agg	p.G728R	FNDC7_ENST00000271311.2_Missense_Mutation_p.G729R	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	729						extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GATTTATAGAGGGAAGAGAAA	0.348000													13	44					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51375642	51375642	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51375642G>A	ENST00000216392.7	-	18	2541	c.2209C>T	c.(2209-2211)Cca>Tca	p.P737S	PYGL_ENST00000532462.1_Missense_Mutation_p.P737S|PYGL_ENST00000544180.2_Missense_Mutation_p.P703S	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	737					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TTCAGCTCTGGAAGTGCCTCA	0.418000													37	113					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98299547	98299547	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98299547G>A	ENST00000264193.2	-	7	1563	c.1345C>T	c.(1345-1347)Cca>Tca	p.P449S		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	449						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CAGTCCCTTGGATGGCGTAGA	0.512000													17	45					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21992957	21992957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21992957G>A	ENST00000327430.3	-	2	1199	c.905C>T	c.(904-906)cCt>cTt	p.P302L	SALL2_ENST00000450879.2_Missense_Mutation_p.P165L|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	302							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GGCTGGGGAAGGGGCAGGGGT	0.612000													15	29					0	0	1	0	0
CA5A	763	broad.mit.edu	37	16	87936081	87936081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:87936081C>T	ENST00000309893.2	-	4	570	c.505G>A	c.(505-507)Gaa>Aaa	p.E169K		NM_001739.1	NP_001730.1	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial	169					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding			large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(80;0.0513)		ACGACAGCTTCCTTGTAATTT	0.393000													26	49					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61623180	61623180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61623180G>A	ENST00000583023.1	+	14	2913	c.2902G>A	c.(2902-2904)Gaa>Aaa	p.E968K	KCNH6_ENST00000314672.5_Missense_Mutation_p.E932K|KCNH6_ENST00000456941.2_Missense_Mutation_p.E879K|KCNH6_ENST00000581784.1_Missense_Mutation_p.E879K	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	968					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CTCCCTCCCTGAACACCTTGG	0.562000													32	77					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10468411	10468411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10468411G>A	ENST00000529370.1	-	17	2825	c.2495C>T	c.(2494-2496)cCc>cTc	p.P832L	TYK2_ENST00000264818.6_Intron|TYK2_ENST00000525621.1_Intron|TYK2_ENST00000524462.1_Intron			P29597	TYK2_HUMAN	tyrosine kinase 2	0	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCCCACTGCGGGGAGGGCCCA	0.612000													6	5					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759380	121759380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121759380G>A	ENST00000261367.7	+	6	2517	c.1089G>A	c.(1087-1089)ctG>ctA	p.L363L	SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000379533.2_Silent_p.L363L|SNCAIP_ENST00000503116.2_Silent_p.L363L|SNCAIP_ENST00000261368.8_Silent_p.L316L|SNCAIP_ENST00000379536.2_Silent_p.L316L|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000504884.2_Intron			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	316					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GTGAGTATCTGAAAAAAGTGA	0.443000													13	96					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43753252	43753252	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:43753252C>T	ENST00000458276.2	+	4	681	c.558C>T	c.(556-558)gaC>gaT	p.D186D		NM_016006.4	NP_057090.2	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	186					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			kidney(3)|large_intestine(2)|liver(2)|lung(5)|ovary(1)|skin(1)	14		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		AACGACCAGACCTTGCTGATC	0.453000													46	103					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108175647	108175647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108175647G>A	ENST00000273353.3	-	20	2220	c.2164C>T	c.(2164-2166)Cca>Tca	p.P722S	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	722	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AGTCGGTTTGGAAAACCTTCA	0.438000													13	178					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156498719	156498719	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156498719G>A	ENST00000361170.2	-	35	4570	c.4560C>T	c.(4558-4560)gcC>gcT	p.A1520A		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1520					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGAGTCGGGGGCCAGGTGGT	0.572000													17	69					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169539934	169539934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169539934C>T	ENST00000340806.6	+	1	225	c.225C>T	c.(223-225)gtC>gtT	p.V75V		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	75										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ACATCAGGGTCCTCTACCTGG	0.502000													40	82					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113637901	113637901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113637901G>A	ENST00000374431.3	-	5	1278	c.895C>T	c.(895-897)Ctt>Ttt	p.L299F	LPAR1_ENST00000541779.1_Missense_Mutation_p.L300F|LPAR1_ENST00000358883.4_Missense_Mutation_p.L299F|LPAR1_ENST00000538760.1_Missense_Mutation_p.L300F|LPAR1_ENST00000374430.2_Missense_Mutation_p.L299F	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	299					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						AATTCAGCAAGGAGAAGGAAG	0.502000													38	87					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43757787	43757787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43757787C>T	ENST00000270077.3	-	6	1351	c.1255G>A	c.(1255-1257)Gga>Aga	p.G419R	PSG9_ENST00000443718.3_Missense_Mutation_p.G326R|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000593948.1_Missense_Mutation_p.G326R|PSG9_ENST00000291752.5_Missense_Mutation_p.G233R	NM_002784.3	NP_002775.3	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	419					female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				gtcaggtctccatggcaggga	0.453000													7	105					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94845910	94845910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94845910C>T	ENST00000448921.1	-	6	1528	c.956G>A	c.(955-957)gGa>gAa	p.G319E	SERPINA1_ENST00000393087.4_Missense_Mutation_p.G319E|SERPINA1_ENST00000449399.3_Missense_Mutation_p.G319E|SERPINA1_ENST00000437397.1_Missense_Mutation_p.G319E|SERPINA1_ENST00000404814.4_Missense_Mutation_p.G319E|SERPINA1_ENST00000402629.1_Missense_Mutation_p.G319E|SERPINA1_ENST00000440909.1_Missense_Mutation_p.G319E|SERPINA1_ENST00000355814.4_Missense_Mutation_p.G319E|SERPINA1_ENST00000393088.4_Missense_Mutation_p.G319E	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	319					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity	p.G319V(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	ATCATAGGTTCCAGTAATGGA	0.522000													13	137					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110788861	110788861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110788861C>T	ENST00000327908.3	+	3	869	c.105C>T	c.(103-105)gtC>gtT	p.V35V	LRIT3_ENST00000409621.2_Silent_p.V35V|LRIT3_ENST00000379920.3_Silent_p.V173V|LRIT3_ENST00000594814.1_Silent_p.V218V			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	173						integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TGTCAAAGGTCGTTGACCCTG	0.443000													26	78					0	0	1	0	0
IFLTD1	160492	broad.mit.edu	37	12	25699359	25699359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25699359G>A	ENST00000539744.1	-	4	565	c.86C>T	c.(85-87)aCt>aTt	p.T29I	IFLTD1_ENST00000445693.1_Missense_Mutation_p.T63I|IFLTD1_ENST00000413632.2_Missense_Mutation_p.T147I|IFLTD1_ENST00000282881.6_Missense_Mutation_p.T126I|IFLTD1_ENST00000458174.2_Missense_Mutation_p.T147I	NM_001256266.1	NP_001243195.1	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	126						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					GTATTTTAAAGTTTTCTGAGT	0.363000													23	61					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75265490	75265490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75265490C>T	ENST00000325680.7	+	5	3614	c.3490C>T	c.(3490-3492)Cgt>Tgt	p.R1164C	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Missense_Mutation_p.R969C	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	969	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck		p.R969C(1)|p.R1164C(1)		breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGATTTTGGTCGTGATAGAGG	0.542000													8	55					0	0	1	0	0
WDR75	84128	broad.mit.edu	37	2	190328438	190328438	+	Missense_Mutation	SNP	G	G	A	rs144965982		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:190328438G>A	ENST00000314761.4	+	10	1016	c.956G>A	c.(955-957)cGa>cAa	p.R319Q		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	319						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			ATTATTCACCGAAACCTTGAA	0.368000													38	81					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167045758	167045758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167045758C>T	ENST00000392766.2	-	11	1174	c.834G>A	c.(832-834)aaG>aaA	p.K278K	ZBBX_ENST00000307529.5_Silent_p.K278K|ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Silent_p.K249K|ZBBX_ENST00000392767.2_Silent_p.K278K|ZBBX_ENST00000455345.2_Silent_p.K278K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	278						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AATTCTGTTTCTTGTTGTCAT	0.418000													50	91					0	0	1	0	0
TGFB2	7042	broad.mit.edu	37	1	218609363	218609363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:218609363C>T	ENST00000366929.4	+	6	1357	c.890C>T	c.(889-891)tCc>tTc	p.S297F	TGFB2_ENST00000479322.1_3'UTR|TGFB2_ENST00000366930.4_Missense_Mutation_p.S269F	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	269					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		ACTATAAAGTCCACTAGGAAA	0.423000													39	77					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27204092	27204092	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:27204092G>A	ENST00000429845.2	-	32	3232	c.2869_splice	c.e32-1	p.A957_splice	NEK10_ENST00000498182.1_Intron|NEK10_ENST00000295720.6_Splice_Site_p.A269_splice|NEK10_ENST00000383771.4_Splice_Site_p.A269_splice|NEK10_ENST00000357467.2_Splice_Site_p.A354_splice|NEK10_ENST00000383770.3_Intron			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	957							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AGGCAGCAAAGCTGAAGAAAT	0.418000													17	58					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71631932	71631932	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71631932C>T	ENST00000356340.3	+	3	901	c.364_splice	c.e3-1	p.A122_splice	COL13A1_ENST00000398968.3_Splice_Site_p.A122_splice|COL13A1_ENST00000520133.1_Intron|COL13A1_ENST00000398966.3_Splice_Site_p.A122_splice|COL13A1_ENST00000398969.3_Intron|COL13A1_ENST00000398974.3_Splice_Site_p.A122_splice|COL13A1_ENST00000398972.3_Intron|COL13A1_ENST00000398973.3_Intron|COL13A1_ENST00000398971.3_Splice_Site_p.A122_splice|COL13A1_ENST00000520267.1_Intron|COL13A1_ENST00000398964.3_Splice_Site_p.A122_splice|COL13A1_ENST00000357811.3_Intron|COL13A1_ENST00000354547.3_Intron|COL13A1_ENST00000517713.1_Intron|COL13A1_ENST00000522165.1_Intron|COL13A1_ENST00000398978.3_Intron			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	122	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	CGTCACTCTTCATTTCAGGGT	0.483000													13	39					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99917221	99917221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99917221G>A	ENST00000332397.6	+	9	1564	c.1380G>A	c.(1378-1380)gaG>gaA	p.E460E	SPDYE3_ENST00000437326.2_Silent_p.E83E	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	460										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						AGGACGACGAGGCCCCCAAAC	0.552000													48	90					0	0	1	0	0
RASL11A	387496	broad.mit.edu	37	13	27847352	27847352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:27847352C>T	ENST00000241463.4	+	4	1068	c.450C>T	c.(448-450)gaC>gaT	p.D150D	RASL11A_ENST00000480803.1_3'UTR	NM_206827.1	NP_996563.1	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	150	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	10		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		ACAAGGGGGACCTTTTGCATG	0.532000													19	42					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45242109	45242109	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45242109G>A	ENST00000279027.4	-	2	385	c.367C>T	c.(367-369)Cag>Tag	p.Q123*	SLC13A3_ENST00000339636.3_Nonsense_Mutation_p.Q123*|SLC13A3_ENST00000495082.1_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000435032.1_5'UTR|SLC13A3_ENST00000290317.5_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000417157.2_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000396360.1_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000372121.1_Nonsense_Mutation_p.Q123*|SLC13A3_ENST00000472148.1_Nonsense_Mutation_p.Q76*|SLC13A3_ENST00000413164.2_Nonsense_Mutation_p.Q123*	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	123						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CTGGCCGGCTGGACTCCAACA	0.562000													19	49					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46832728	46832728	+	Missense_Mutation	SNP	C	C	T	rs140829009		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46832728C>T	ENST00000339613.2	+	12	1792	c.1537C>T	c.(1537-1539)Cgg>Tgg	p.R513W	HIF3A_ENST00000244303.6_Missense_Mutation_p.R500W|HIF3A_ENST00000420102.2_Missense_Mutation_p.R518W|AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000600383.1_Missense_Mutation_p.R500W|HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000300862.3_Missense_Mutation_p.R567W|HIF3A_ENST00000377670.4_Missense_Mutation_p.R569W			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	569	ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GGCTGGGGCTCGGAAGAGGTG	0.652000													6	10					0	0	1	0	0
FITM1	161247	broad.mit.edu	37	14	24600934	24600934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24600934C>T	ENST00000558325.1	+	3	724	c.724C>T	c.(724-726)Cct>Tct	p.242_242insS	FITM1_ENST00000267426.5_Silent_p.R54R																							GCTTACGGCGCCTCTACCATG	0.617000													22	58					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255615	15255615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15255615G>A	ENST00000378116.4	-	8	1978	c.1972C>T	c.(1972-1974)Cct>Tct	p.P658S		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	658						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GCGTTCTGAGGGCTCCACTCC	0.607000													19	71					0	0	1	0	0
CORO2A	7464	broad.mit.edu	37	9	100890474	100890474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:100890474C>T	ENST00000343933.5	-	10	1406	c.1149G>A	c.(1147-1149)gaG>gaA	p.E383E	CORO2A_ENST00000375077.4_Silent_p.E383E	NM_003389.3	NP_003380.3	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	383					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|skin(4)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				CGCTGAGCCACTCCTGGGCCG	0.592000													96	271					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237791147	237791147	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237791147G>A	ENST00000366574.2	+	41	6524	c.6207G>A	c.(6205-6207)tgG>tgA	p.W2069*	RYR2_ENST00000360064.6_Nonsense_Mutation_p.W2067*|RYR2_ENST00000542537.1_Nonsense_Mutation_p.W2053*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2069	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGTCCGATGGGCTCAGGAGT	0.493000													6	25					0	0	1	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841548	8841548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8841548C>T	ENST00000324060.2	+	1	233	c.158C>T	c.(157-159)tCc>tTc	p.S53F		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CGTGTGGACTCCCGGCTCCAT	0.547000													44	114					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15290705	15290705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15290705G>A	ENST00000378116.4	-	5	693	c.687C>T	c.(685-687)ccC>ccT	p.P229P	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	229						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GCGTGGCCAGGGGCACAGTGA	0.602000													26	83					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17405782	17405782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17405782G>A	ENST00000375486.4	-	11	1350	c.1287C>T	c.(1285-1287)atC>atT	p.I429I	PADI2_ENST00000466151.1_5'UTR|PADI2_ENST00000375481.1_Silent_p.I429I|PADI2_ENST00000444885.2_Silent_p.I313I	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	429					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TCCCGATGAGGATGCGGCCAA	0.582000													14	51					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101295478	101295478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101295478G>A	ENST00000538618.1	+	4	413	c.413G>A	c.(412-414)cGa>cAa	p.R138Q	ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000392977.3_5'UTR|ANO4_ENST00000299222.9_5'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CATCAACGGCGAAGTGTGGCA	0.498000										HNSCC(74;0.22)			24	49					0	0	1	0	0
TRBV11-2	28581	broad.mit.edu	37	7	142198025	142198025	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142198025G>A	ENST00000471935.1	-	0	44																											GTCAGGGAAGGATGGGAGCTT	0.577000													21	58					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25766052	25766052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:25766052G>A	ENST00000520164.1	-	7	1108	c.571C>T	c.(571-573)Ctc>Ttc	p.L191F	EBF2_ENST00000408929.3_Missense_Mutation_p.L43F	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	191					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TTGCACTTGAGGAAAAATTTT	0.363000													7	66					0	0	1	0	0
CDK9	1025	broad.mit.edu	37	9	130550648	130550648	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130550648C>T	ENST00000373265.2	+	5	939	c.939C>T	c.(937-939)ccC>ccT	p.P313P	CDK9_ENST00000373264.4_Silent_p.P196P|CDK9_ENST00000480353.1_3'UTR			P50750	CDK9_HUMAN	cyclin-dependent kinase 9	196	Protein kinase.				cell proliferation|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription elongation factor complex	ATP binding|cyclin-dependent protein kinase activity|DNA binding|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(1)	1						GGTACCGGCCCCCGGAGCTGT	0.667000													6	17					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36212573	36212573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36212573C>T	ENST00000222270.7	+	3	2324	c.2324C>T	c.(2323-2325)gCc>gTc	p.A775V	WBP7_ENST00000420124.1_Missense_Mutation_p.A775V|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					CTGGAAAAAGCCCGGATTGCG	0.607000													6	25					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156811288	156811288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156811288G>A	ENST00000368195.3	-	21	3956	c.3560C>T	c.(3559-3561)aCc>aTc	p.T1187I	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	1187	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTCTGCCAGGGTCACAATCTC	0.612000													29	58					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36122870	36122870	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36122870C>T	ENST00000303965.4	-	23	4314	c.3825G>A	c.(3823-3825)acG>acA	p.T1275T		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1275	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTTGTCCCTTCGTTTGAAACA	0.338000													7	87					0	0	1	0	0
SLC35G2	80723	broad.mit.edu	37	3	136573671	136573671	+	Silent	SNP	G	G	A	rs142918857	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:136573671G>A	ENST00000446465.2	+	2	997	c.369G>A	c.(367-369)agG>agA	p.R123R	RP11-85F14.5_ENST00000461864.1_RNA|RP11-85F14.5_ENST00000470236.1_RNA|RP11-85F14.5_ENST00000474250.1_RNA|SLC35G2_ENST00000393079.3_Silent_p.R123R	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	123	DUF6 1.					Golgi apparatus|integral to membrane											TTATCACTAGGCTTGTTTCTG	0.393000													63	184					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69337234	69337234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69337234C>T	ENST00000305363.4	+	5	447	c.383C>T	c.(382-384)aCt>aTt	p.T128I		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	128	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TTTCACTCTACTGAGGATCCT	0.373000													87	234					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93098047	93098047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:93098047C>T	ENST00000359558.2	-	8	854	c.555G>A	c.(553-555)ctG>ctA	p.L185L	CALCR_ENST00000426151.1_Silent_p.L167L|CALCR_ENST00000360249.4_Silent_p.L167L|CALCR_ENST00000394441.1_Silent_p.L167L|CALCR_ENST00000421592.1_Silent_p.L167L	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	167					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CGAAAATCCCCAGGGAAATCA	0.383000													13	63					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632266	122632266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122632266G>A	ENST00000195173.4	-	17	2586	c.2283C>T	c.(2281-2283)ttC>ttT	p.F761F	SEMA5B_ENST00000357599.3_Silent_p.F762F|SEMA5B_ENST00000451055.2_Silent_p.F816F			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	762	TSP type-1 2.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		TGCACGTCTTGAACTCCTGCG	0.726000													5	10					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53663157	53663157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53663157C>T	ENST00000257934.4	+	3	522	c.431C>T	c.(430-432)gCt>gTt	p.A144V	ESPL1_ENST00000552462.1_Missense_Mutation_p.A144V	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	144					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						GAGGCCGTGGCTCGGGGCAGC	0.622000													35	48					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122853810	122853810	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122853810C>T	ENST00000264811.5	-	1	802	c.384G>A	c.(382-384)gcG>gcA	p.A128A	TRPC3_ENST00000513531.1_Silent_p.A128A|TRPC3_ENST00000379645.3_Silent_p.A201A	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	116					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCTTGCTGGCCGCGAAGCCAG	0.637000													7	35					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057917	63057917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63057917C>T	ENST00000332793.6	+	1	282	c.280C>T	c.(280-282)Ccc>Tcc	p.P94S	SLC22A10_ENST00000544661.1_5'UTR|SLC22A10_ENST00000526800.1_Missense_Mutation_p.P42S|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	94						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTTTGTCCATCCCCAGTGGCA	0.488000													57	112					0	0	1	0	0
GIT1	28964	broad.mit.edu	37	17	27909760	27909760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:27909760G>A	ENST00000225394.3	-	4	609	c.361C>T	c.(361-363)Ccc>Tcc	p.P121S	GIT1_ENST00000579937.1_Missense_Mutation_p.P121S|RP11-68I3.2_ENST00000581474.1_RNA|GIT1_ENST00000581348.1_Missense_Mutation_p.P121S|GIT1_ENST00000394869.3_Missense_Mutation_p.P121S	NM_014030.3	NP_054749.2	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 1	121	Arf-GAP.			P -> S (in Ref. 1; AAD28046).	regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding			large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		TCCCGGCAGGGAAGCTTGTGC	0.587000													15	21					0	0	1	0	0
NENF	29937	broad.mit.edu	37	1	212619322	212619322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:212619322C>T	ENST00000366988.3	+	4	550	c.493C>T	c.(493-495)Cat>Tat	p.H165Y	NENF_ENST00000473900.1_3'UTR	NM_013349.4	NP_037481.1	Q9UMX5	NENF_HUMAN	neudesin neurotrophic factor	165						extracellular space	heme binding			endometrium(1)|kidney(1)|large_intestine(2)	4				all cancers(67;0.00967)|OV - Ovarian serous cystadenocarcinoma(81;0.0108)|GBM - Glioblastoma multiforme(131;0.0325)|Epithelial(68;0.132)		AGACCAGCCCCATTTTGACAT	0.522000													18	73					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60758262	60758262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60758262G>A	ENST00000303375.5	+	17	2977	c.2575G>A	c.(2575-2577)Gag>Aag	p.E859K		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	859	C-type lectin 5.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GTTCCAGGCCGAGCTGACCTC	0.642000													12	28					0	0	1	0	0
OR5AN1	390195	broad.mit.edu	37	11	59132522	59132522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59132522G>A	ENST00000313940.2	+	1	638	c.591G>A	c.(589-591)caG>caA	p.Q197Q		NM_001004729.1	NP_001004729.1	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN, member 1	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	21						TCTTTGTACAGGTCATGACTG	0.408000													55	113					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	122075625	122075625	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:122075625C>T	ENST00000265922.3	-	2	470	c.9G>A	c.(7-9)tgG>tgA	p.W3*	DBC1_ENST00000373964.2_Nonsense_Mutation_p.W3*	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		3					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CAACAAACCTCCAGTTCATGC	0.463000													10	41					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873228	55873228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55873228C>T	ENST00000313503.1	+	1	710	c.710C>T	c.(709-711)gCt>gTt	p.A237V		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					AAGCAGAAAGCTTTCTCTACT	0.388000										HNSCC(53;0.14)			26	101					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350254	51350254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51350254C>T	ENST00000327536.5	-	3	802	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	235										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		TGCACCAGTTCATGCACCAGG	0.552000													19	40					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169511128	169511128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169511128G>A	ENST00000367796.3	-	13	3416	c.3215C>T	c.(3214-3216)tCg>tTg	p.S1072L	F5_ENST00000367797.3_Missense_Mutation_p.S1067L			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1067	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AAGCACCAACGAATGCTTAAG	0.438000													63	298					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54299171	54299171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54299171C>T	ENST00000324134.6	-	9	3208	c.3040G>A	c.(3040-3042)Ggt>Agt	p.G1014S	NLRP12_ENST00000391772.1_Intron|NLRP12_ENST00000535162.1_Intron|NLRP12_ENST00000391773.1_Missense_Mutation_p.G1015S|NLRP12_ENST00000354278.3_Intron|NLRP12_ENST00000391775.3_Missense_Mutation_p.G957S|NLRP12_ENST00000351894.4_Missense_Mutation_p.G902S|NLRP12_ENST00000345770.5_Intron	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	1014					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGTCGGACACCTGTGTCCCCT	0.557000													10	47					0	0	1	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65714447	65714447	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65714447G>A	ENST00000532620.1	+	0	475							Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein											endometrium(2)|kidney(3)|lung(9)	14						CAAGCCCAGGGGCCAGAGCAA	0.612000													29	71					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73179425	73179425	+	Missense_Mutation	SNP	G	G	A	rs150168072		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73179425G>A	ENST00000286657.4	-	12	1750	c.1714C>T	c.(1714-1716)Cgt>Tgt	p.R572C		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	572	TSP type-1 1.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTTCTGAAACGAACACCAGTT	0.393000													13	43					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031330	79031330	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79031330G>A	ENST00000446378.2	+	2	6773	c.6742G>A	c.(6742-6744)Gaa>Aaa	p.E2248K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2248						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AACTGCTGATGAACCCAGAGG	0.348000													39	86					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488152	24488152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:24488152C>T	ENST00000264463.4	-	12	2494	c.1987G>A	c.(1987-1989)Gga>Aga	p.G663R	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	663					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G663*(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TCCTCCTCTCCACCACCCTCA	0.453000										HNSCC(23;0.051)			34	95					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3746449	3746449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3746449G>A	ENST00000378230.3	-	14	2273	c.1949C>T	c.(1948-1950)cCa>cTa	p.P650L		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	650						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						GCTGTCGTCTGGAGGAAGGTA	0.488000													22	171					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68424575	68424575	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68424575G>A	ENST00000265404.2	+	1	130	c.48G>A	c.(46-48)caG>caA	p.Q16Q	STAP1_ENST00000396225.1_Silent_p.Q16Q	NM_012108.2	NP_036240.1	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	16					cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						GGATCTTCCAGGAAAGGTTAA	0.423000													50	121					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447414	24447414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24447414G>A	ENST00000270800.1	-	7	1644	c.1606C>T	c.(1606-1608)Ctt>Ttt	p.L536F		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	536						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GGACACACAAGGGACTCCAGC	0.617000													6	77					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96051383	96051383	+	Silent	SNP	C	C	T	rs143402775		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96051383C>T	ENST00000297954.4	+	20	4458	c.4458C>T	c.(4456-4458)ctC>ctT	p.L1486L	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Silent_p.L1061L|WNK2_ENST00000349097.3_Silent_p.L1098L|WNK2_ENST00000395477.2_Silent_p.L1449L|WNK2_ENST00000356055.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1486					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TGCAGCCCCTCGTGGTGGGCC	0.677000													3	5					0	0	1	0	0
AQP9	366	broad.mit.edu	37	15	58430866	58430866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:58430866C>T	ENST00000219919.4	+	1	472	c.102C>T	c.(100-102)ttC>ttT	p.F34F	AQP9_ENST00000536493.1_Silent_p.F34F|ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000559443.1_3'UTR|AQP9_ENST00000558772.1_Intron	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9	34					cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		TGGGCACGTTCATCTTGATTG	0.453000													11	80					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117885049	117885049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:117885049C>T	ENST00000439649.3	-	5	805	c.438G>A	c.(436-438)ggG>ggA	p.G146G	GFRA1_ENST00000369236.1_Silent_p.G146G|GFRA1_ENST00000544592.1_Silent_p.G30G|GFRA1_ENST00000355422.6_Silent_p.G151G	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	151					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		GGCAGTTGTTCCCTTTGGGAA	0.537000													6	14					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975383	20975383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20975383C>T	ENST00000261383.3	-	53	9822	c.9823G>A	c.(9823-9825)Gag>Aag	p.E3275K	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3275	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTCTGTTTCTCTGAGATCTCT	0.478000													48	132					0	0	1	0	0
TPCN2	219931	broad.mit.edu	37	11	68835021	68835021	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68835021T>C	ENST00000294309.3	+	8	878	c.777T>C	c.(775-777)ccT>ccC	p.P259P	TPCN2_ENST00000442692.2_3'UTR|TPCN2_ENST00000542467.1_Silent_p.P259P	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	259					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AGAACCTGCCTGAGTCTCTGA	0.652000													28	78					0	0	1	0	0
HNRNPKP3	399881	broad.mit.edu	37	11	43283595	43283595	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:43283595G>A	ENST00000511537.1	-	0	1340					NR_033868.1																						TTTTTAAACAGAAGCAAATGT	0.388000													4	1					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71394475	71394475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:71394475G>A	ENST00000392650.3	-	23	3187	c.3187C>T	c.(3187-3189)Ccc>Tcc	p.P1063S	SDK2_ENST00000388726.3_Missense_Mutation_p.P1063S	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1063	Fibronectin type-III 5.				cell adhesion	integral to membrane		p.P1063S(1)		breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CAGGTGAAGGGGTTGAGGTCG	0.637000													23	82					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238277716	238277716	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238277716G>A	ENST00000295550.4	-	10	4842	c.4390C>T	c.(4390-4392)Cga>Tga	p.R1464*	COL6A3_ENST00000409809.1_Nonsense_Mutation_p.R1258*|COL6A3_ENST00000472056.1_Nonsense_Mutation_p.R857*|COL6A3_ENST00000346358.4_Nonsense_Mutation_p.R1264*|COL6A3_ENST00000353578.4_Nonsense_Mutation_p.R1258*|COL6A3_ENST00000347401.3_Nonsense_Mutation_p.R1263*	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1464	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.R1464*(1)		breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTGAGTCTTCGAACAATCCTG	0.473000													20	36					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933793	44933793	+	Missense_Mutation	SNP	C	C	T	rs148444351	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44933793C>T	ENST00000291187.4	-	6	1467	c.1145G>A	c.(1144-1146)cGa>cAa	p.R382Q	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Missense_Mutation_p.R388Q	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GTTTGAACTTCGACCAAATGC	0.478000													13	175					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848367	73848367	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73848367G>A	ENST00000523207.1	+	3	1365	c.777G>A	c.(775-777)tgG>tgA	p.W259*		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	259					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CAAATAAATGGAAGTTCTTCA	0.453000													26	81					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155119159	155119159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:155119159G>A	ENST00000286448.6	+	2	195	c.30G>A	c.(28-30)agG>agA	p.R10R	VAMP7_ENST00000460621.1_Silent_p.R10R|VAMP7_ENST00000479687.1_3'UTR|VAMP7_ENST00000262640.6_Silent_p.R10R	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	10	Longin.				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTGTTGCCAGGGGGACCACTA	0.403000													46	112					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2022195	2022195	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2022195C>T	ENST00000382722.5	-	3	782	c.420G>A	c.(418-420)gcG>gcA	p.A140A	CACNA2D4_ENST00000586184.1_Silent_p.A140A|CACNA2D4_ENST00000585732.1_Silent_p.A140A|CACNA2D4_ENST00000585708.1_Silent_p.A76A|CACNA2D4_ENST00000587995.1_Silent_p.A140A|CACNA2D4_ENST00000588077.1_Silent_p.A76A	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	140						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GTACCTGGACCGCCTCGACTT	0.597000													4	19					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64390363	64390363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64390363G>A	ENST00000265459.6	-	21	4496	c.4035C>T	c.(4033-4035)tcC>tcT	p.S1345S	NRXN2_ENST00000377559.3_Silent_p.S1275S|NRXN2_ENST00000409571.1_Silent_p.S1338S|NRXN2_ENST00000377551.1_Silent_p.S1345S|NRXN2_ENST00000301894.2_Silent_p.S299S	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1345	Laminin G-like 6.				cell adhesion	integral to membrane	metal ion binding	p.S1345S(1)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TGAGCAGCACGGACGGCCCCT	0.672000													10	16					0	0	1	0	0
ZGPAT	84619	broad.mit.edu	37	20	62367218	62367218	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62367218C>A	ENST00000328969.5	+	7	1670	c.1543C>A	c.(1543-1545)Ctg>Atg	p.L515M	ZGPAT_ENST00000448100.1_Missense_Mutation_p.L495M|ZGPAT_ENST00000357119.4_Missense_Mutation_p.L486M|ZGPAT_ENST00000355969.6_Missense_Mutation_p.L495M|ZGPAT_ENST00000490623.1_3'UTR|ZGPAT_ENST00000369967.3_Missense_Mutation_p.L495M	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	515					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					GGAAGCCGGCCTGCAGCAGGA	0.652000													26	37					2.12542e-12	2.13567e-12	1	1	0
PHF20L1	51105	broad.mit.edu	37	8	133811053	133811053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133811053C>T	ENST00000395386.2	+	5	675	c.376C>T	c.(376-378)Cgt>Tgt	p.R126C	PHF20L1_ENST00000337920.4_Missense_Mutation_p.R126C|PHF20L1_ENST00000220847.7_5'UTR|PHF20L1_ENST00000395376.1_Missense_Mutation_p.R126C|PHF20L1_ENST00000395382.3_5'UTR|PHF20L1_ENST00000395383.1_Missense_Mutation_p.R126C|PHF20L1_ENST00000395390.2_Missense_Mutation_p.R126C|PHF20L1_ENST00000315808.10_Missense_Mutation_p.R126C|PHF20L1_ENST00000395379.1_Missense_Mutation_p.R126C	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	126	Tudor 2.						nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGGAGTAATTCGTTGTTTAAA	0.373000													8	22					0	0	1	0	0
MAPK10	5602	broad.mit.edu	37	4	87080462	87080462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:87080462C>T	ENST00000395169.3	-	4	831	c.111G>A	c.(109-111)caG>caA	p.Q37Q	MAPK10_ENST00000395166.1_Silent_p.Q37Q|MAPK10_ENST00000513839.1_5'UTR|MAPK10_ENST00000395161.2_Silent_p.Q75Q|MAPK10_ENST00000359221.3_Silent_p.Q75Q|MAPK10_ENST00000449047.2_5'UTR|MAPK10_ENST00000361569.2_Silent_p.Q75Q|RP11-778J15.1_ENST00000511917.1_RNA	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	75					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding	p.Q75H(1)		breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		AAACTATGCCCTGAGCCCCAG	0.448000													36	119					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46318912	46318912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46318912G>A	ENST00000245934.7	-	27	3975	c.3731C>T	c.(3730-3732)cCc>cTc	p.P1244L	SYMPK_ENST00000598155.1_5'UTR	NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	1244					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GAGGGTCTGGGGGCTCCGCTC	0.692000													5	17					0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138394383	138394383	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138394383G>A	ENST00000310018.2	-	21	2697	c.2415C>T	c.(2413-2415)gcC>gcT	p.A805A	ATP6V0A4_ENST00000393054.1_Silent_p.A805A|ATP6V0A4_ENST00000353492.4_Silent_p.A805A	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	805					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GCAGTCGCAGGGCGTGCAGGA	0.552000													83	212					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340705	121340705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121340705G>A	ENST00000338040.4	+	3	843	c.429G>A	c.(427-429)atG>atA	p.M143I		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	143					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		CCTTGAAAATGGTGGAACTTT	0.507000													11	34					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54554694	54554694	+	Missense_Mutation	SNP	C	C	T	rs147285202	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54554694C>T	ENST00000338372.2	-	4	539	c.364G>A	c.(364-366)Gat>Aat	p.D122N	VSTM1_ENST00000366170.2_Missense_Mutation_p.D34N|VSTM1_ENST00000425006.2_Missense_Mutation_p.D122N|VSTM1_ENST00000376626.1_Missense_Mutation_p.D122N	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	122						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TCAAGTTCATCGTGTTTATCT	0.393000													14	27					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156589787	156589787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156589787G>A	ENST00000302938.4	-	2	1584	c.1489C>T	c.(1489-1491)Cgc>Tgc	p.R497C		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	497						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGCTCTTGCGAGAGGAGCCA	0.502000													13	148					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95604975	95604975	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95604975G>A	ENST00000343958.4	-	2	308	c.85C>T	c.(85-87)Cct>Tct	p.P29S	FGD6_ENST00000549499.1_Missense_Mutation_p.P29S|FGD6_ENST00000546711.1_Missense_Mutation_p.P29S	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	29					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						GGTGCAATAGGAGGTGGGGCT	0.428000													89	163					0	0	1	0	0
PTAFR	5724	broad.mit.edu	37	1	28477113	28477113	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28477113G>A	ENST00000373857.3	-	2	1054	c.420C>T	c.(418-420)gtC>gtT	p.V140V	PTAFR_ENST00000305392.3_Silent_p.V140V|PTAFR_ENST00000539896.1_Silent_p.V140V	NM_000952.4|NM_001164722.2|NM_001164723.2	NP_000943.1|NP_001158194.1|NP_001158195.1	P25105	PTAFR_HUMAN	platelet-activating factor receptor	140					chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|stomach(1)	15		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCCAGATGACCAAGGACA	0.577000													29	86					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66883549	66883549	+	Silent	SNP	G	G	A	rs142750568		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66883549G>A	ENST00000269080.2	-	23	3260	c.3123C>T	c.(3121-3123)ttC>ttT	p.F1041F	ABCA8_ENST00000586539.1_Silent_p.F1081F|ABCA8_ENST00000430352.2_Silent_p.F1081F	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1041						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					ATATAAAAACGAAGACCAAGA	0.413000													53	210					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	71535217	71535217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71535217C>T	ENST00000355327.3	+	5	828	c.694C>T	c.(694-696)Cgc>Tgc	p.R232C	THSD4_ENST00000261862.6_Missense_Mutation_p.R232C			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	232	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CAGTGGCCCTCGCTCTGGACT	0.577000													22	99					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201351789	201351789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201351789C>T	ENST00000391967.2	-	8	1766	c.1465G>A	c.(1465-1467)Gac>Aac	p.D489N	LAD1_ENST00000367313.3_Missense_Mutation_p.D503N	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	489						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						ACCTGGGGGTCCTGATCTCCA	0.542000													9	13					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39880407	39880407	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39880407G>C	ENST00000260356.5	+	9	1624	c.1459G>C	c.(1459-1461)Gac>Cac	p.D487H		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	487	TSP type-1 2.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CTGCAAGAAAGACGCCTGCCC	0.612000													22	44					0	0	1	0	0
POU2F3	25833	broad.mit.edu	37	11	120188070	120188070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120188070C>T	ENST00000260264.4	+	12	1308	c.1274C>T	c.(1273-1275)tCa>tTa	p.S425L	POU2F3_ENST00000543440.2_Missense_Mutation_p.S423L	NM_001244682.1	NP_001231611.1	Q9UKI9	PO2F3_HUMAN	POU class 2 homeobox 3	423	Ser-rich.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)	17		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		TTTAACTCTTCAGGGTAAGGT	0.532000													28	78					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81697726	81697726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81697726C>T	ENST00000372292.3	-	8	1050	c.1010G>A	c.(1009-1011)tGg>tAg	p.W337*		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	337	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CCCTGGGGCCCAGTTGGAATA	0.547000													75	212					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080195	54080195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54080195G>A	ENST00000253144.9	+	7	1714	c.381G>A	c.(379-381)aaG>aaA	p.K127K	ZNF331_ENST00000449416.1_Silent_p.K127K|ZNF331_ENST00000513999.1_Silent_p.K127K|ZNF331_ENST00000411977.2_Silent_p.K127K|ZNF331_ENST00000512387.1_Silent_p.K127K|ZNF331_ENST00000511154.1_Silent_p.K127K|ZNF331_ENST00000513265.1_Intron|ZNF331_ENST00000511593.2_Silent_p.K127K	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GACATCATAAGGAGAATTCCT	0.423000			T	?	follicular thyroid adenoma								36	85					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12639525	12639525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12639525G>A	ENST00000425538.1	+	6	663	c.463G>A	c.(463-465)Gag>Aag	p.E155K	MYOCD_ENST00000395988.1_Missense_Mutation_p.E59K|MYOCD_ENST00000343344.4_Missense_Mutation_p.E155K	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	155	HDAC5-binding (By similarity).				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TGCCTTTGAAGAGGACAGCAG	0.547000													88	130					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075177	106075177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106075177G>A	ENST00000278071.2	-	3	1085	c.633C>T	c.(631-633)ttC>ttT	p.F211F	ITPRIP_ENST00000358187.2_Silent_p.F211F|ITPRIP_ENST00000337478.1_Silent_p.F211F	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	211						plasma membrane		p.F211F(1)		breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						TGAAGGGCACGAAAAGGTGGC	0.637000													34	62					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756582	15756582	+	Silent	SNP	C	C	T	rs148575704	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15756582C>T	ENST00000221307.7	+	3	300	c.252C>T	c.(250-252)ttC>ttT	p.F84F	CYP4F3_ENST00000591058.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000586182.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	84					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding	p.F84F(1)		endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CATGCACCTTCGGTGATATGT	0.557000													34	76					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838180	112838180	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:112838180C>A	ENST00000280155.2	+	1	1391	c.426C>A	c.(424-426)atC>atA	p.I142I		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	127					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	TGTGCGCCATCAGCCTGGACC	0.602000													11	37					1.61879e-10	1.62543e-10	1	1	0
CSF2RB	1439	broad.mit.edu	37	22	37334447	37334447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37334447C>T	ENST00000262825.5	+	14	2832	c.2615C>T	c.(2614-2616)cCc>cTc	p.P872L	CSF2RB_ENST00000536485.1_Missense_Mutation_p.P813L|CSF2RB_ENST00000406230.1_Missense_Mutation_p.P872L|CSF2RB_ENST00000403662.3_Missense_Mutation_p.P866L	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	866					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CAGGCTGTGCCCCAGGTGCCC	0.592000													43	162					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149129189	149129189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149129189G>A	ENST00000247930.4	-	6	2497	c.2174C>T	c.(2173-2175)cCc>cTc	p.P725L		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CTCGCACTCGGGGCACTTGAA	0.677000													25	108					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21153424	21153424	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21153424A>T	ENST00000269228.5	-	2	726	c.172T>A	c.(172-174)Tta>Ata	p.L58I	NPC1_ENST00000540608.1_Intron	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	58					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ACCTGCACTAAGTCATATCCA	0.423000													58	141					0	0	1	0	0
IL17A	3605	broad.mit.edu	37	6	52052496	52052496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52052496C>T	ENST00000340057.1	+	2	168	c.123C>T	c.(121-123)ttC>ttT	p.F41F		NM_002190.2	NP_002181.1	Q16552	IL17_HUMAN	interleukin 17A	41					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity	p.F41F(1)		endometrium(3)|large_intestine(2)|lung(8)|prostate(3)|skin(1)	17	Lung NSC(77;0.116)					ACAAGAACTTCCCCCGGACTG	0.498000													16	203					0	0	1	0	0
ENKUR	219670	broad.mit.edu	37	10	25279504	25279504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25279504C>T	ENST00000331161.4	-	4	701	c.482G>A	c.(481-483)cGa>cAa	p.R161Q	ENKUR_ENST00000376363.1_Missense_Mutation_p.R161Q	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	161						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						TTCCTCGTTTCGCTTACATAT	0.358000													12	59					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36124361	36124361	+	Missense_Mutation	SNP	G	G	A	rs139182630		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36124361G>A	ENST00000296603.4	-	7	1216	c.754C>T	c.(754-756)Cgt>Tgt	p.R252C		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	252						integral to membrane		p.R252C(1)		breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTCACTTTACGAACCTCCTAT	0.279000													15	43					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128840283	128840283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128840283G>A	ENST00000310343.9	-	22	4782	c.4783C>T	c.(4783-4785)Cgc>Tgc	p.R1595C	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.R1246C|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.R1246C	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1595	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GGAACAGAGCGAATCATGGAA	0.542000													20	43					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120430	94120430	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:94120430G>A	ENST00000369303.4	-	3	805	c.621C>T	c.(619-621)tcC>tcT	p.S207S	EPHA7_ENST00000369297.1_Silent_p.S207S	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	207	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TCTCAATAATGGACCAGCACT	0.438000													5	55					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50534736	50534736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50534736G>A	ENST00000267845.3	-	12	2112	c.1710C>T	c.(1708-1710)ttC>ttT	p.F570F	HDC_ENST00000543581.1_Silent_p.F537F	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	570					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ACAAGTAACTGAACAGGAAGG	0.537000													53	152					0	0	1	0	0
MYBPH	4608	broad.mit.edu	37	1	203144855	203144855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203144855G>A	ENST00000255416.4	-	1	86	c.29C>T	c.(28-30)cCt>cTt	p.P10L		NM_004997.2	NP_004988.2	Q13203	MYBPH_HUMAN	myosin binding protein H	10					cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle			endometrium(5)|large_intestine(6)|lung(7)|skin(1)|urinary_tract(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		ACTGCAGGCAGGGCCCTCGGA	0.627000													39	86					0	0	1	0	0
LHFPL3	375612	broad.mit.edu	37	7	104377342	104377342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:104377342G>A	ENST00000535008.1	+	4	790	c.666G>A	c.(664-666)ctG>ctA	p.L222L	LHFPL3_ENST00000401970.2_Silent_p.L208L|LHFPL3_ENST00000543266.1_Silent_p.L222L|LHFPL3_ENST00000424859.1_Silent_p.L208L			Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	208						integral to membrane				kidney(1)|large_intestine(2)|lung(6)	9						CAGAGGAACTGAAGGCAGAAA	0.418000													6	12					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159778902	159778902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159778902G>A	ENST00000321935.6	+	5	578	c.492G>A	c.(490-492)caG>caA	p.Q164Q	FCRL6_ENST00000392235.3_Intron|FCRL6_ENST00000339348.5_Silent_p.Q157Q|FCRL6_ENST00000368106.3_Silent_p.Q157Q			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	157	Ig-like C2-type 2.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					ACACCTTGCAGGACAGGGGCC	0.617000													15	65					0	0	1	0	0
AQP12B	653437	broad.mit.edu	37	2	241622226	241622226	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241622226A>T	ENST00000407834.3	-	1	91	c.29T>A	c.(28-30)tTc>tAc	p.F10Y		NM_001102467.1	NP_001095937.1	A6NM10	AQ12B_HUMAN	aquaporin 12B	10						integral to membrane	transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|lung(8)|ovary(1)	13		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GGCAAAGAAGAAGGAGAGGGA	0.667000													29	75					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112770107	112770107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:112770107G>A	ENST00000390666.3	-	1	621	c.430C>T	c.(430-432)Ctt>Ttt	p.L144F	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000416046.2_RNA|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	144	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TCCTTGTCAAGGAGAAGGTTG	0.547000													30	41					0	0	1	0	0
MAP3K11	4296	broad.mit.edu	37	11	65373509	65373509	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65373509G>A	ENST00000309100.3	-	7	2132	c.1647C>T	c.(1645-1647)ccC>ccT	p.P549P	MAP3K11_ENST00000532507.1_5'UTR|MAP3K11_ENST00000534432.1_5'UTR|MAP3K11_ENST00000530153.1_Silent_p.P292P	NM_002419.3	NP_002410.1	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase 11	549					activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(14)|skin(1)	24						CCAGACGTCGGGGGGACTGGC	0.607000													8	21					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	174096	174096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:174096C>T	ENST00000283426.6	+	16	3267	c.3217C>T	c.(3217-3219)Cgc>Tgc	p.R1073C		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	1073	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GATTTGGTTTCGCAGGCGGCG	0.562000													5	12					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22149821	22149821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:22149821G>A	ENST00000389398.5	+	22	2376	c.2280G>A	c.(2278-2280)ctG>ctA	p.L760L	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	760						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CCGTCCCCCTGGGGGCCAGAA	0.527000													4	34					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17235031	17235031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:17235031G>A	ENST00000261381.6	-	7	1650	c.1566C>T	c.(1564-1566)tcC>tcT	p.S522S		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	522					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GCAGGGTGTAGGAGTAGAACT	0.478000													38	316					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107113782	107113782	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107113782G>A	ENST00000392842.1	+	12	1597	c.1183G>A	c.(1183-1185)Gag>Aag	p.E395K	RFX4_ENST00000229387.5_Missense_Mutation_p.E301K|RP11-144F15.1_ENST00000551505.1_Intron|RP11-482D24.3_ENST00000552415.1_RNA|RFX4_ENST00000357881.4_Missense_Mutation_p.E404K	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	395	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GTCTCCCATCGAGTCCTACAT	0.527000													31	76					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203188883	203188883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203188883G>A	ENST00000367229.1	-	8	858	c.824C>T	c.(823-825)tCc>tTc	p.S275F	CHIT1_ENST00000535569.1_Missense_Mutation_p.S266F|CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000255427.3_Missense_Mutation_p.S256F	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	275					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						GTCTGATGAGGAGGCCAGTGT	0.602000													34	60					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878721	24878721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24878721G>A	ENST00000382554.3	+	4	2039	c.1721G>A	c.(1720-1722)cGa>cAa	p.R574Q		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	574					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCTACATCTCGAATGATGCTG	0.527000													8	23					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25415724	25415724	+	RNA	SNP	C	C	T	rs77022855	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25415724C>T	ENST00000549301.1	+	0	238				SNHG14_ENST00000553149.1_RNA																							CCCAATGGCCCTCGGCCAGTG	0.617000													9	26					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33648129	33648129	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33648129C>T	ENST00000374316.5	+	33	5308	c.4248C>T	c.(4246-4248)ttC>ttT	p.F1416F	ITPR3_ENST00000605930.1_Silent_p.F1416F			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1416					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						ATGTGAACTTCGTGAACCACT	0.602000													14	38					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100488880	100488880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100488880C>T	ENST00000302913.4	-	4	1771	c.1633G>A	c.(1633-1635)Gac>Aac	p.D545N	ACHE_ENST00000411582.1_Missense_Mutation_p.D545N|ACHE_ENST00000241069.5_Missense_Mutation_p.D545N|ACHE_ENST00000428317.1_Missense_Mutation_p.D545N|ACHE_ENST00000412389.1_Missense_Mutation_p.D545N|ACHE_ENST00000419336.2_Missense_Mutation_p.D457N	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	545					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GGCCGCAGGTCCAGACTAACG	0.687000													18	33					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81664975	81664975	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81664975G>A	ENST00000558726.1	-	2	328	c.193C>T	c.(193-195)Cgc>Tgc	p.R65C	TMC3_ENST00000359440.5_Missense_Mutation_p.R65C			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	65						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						GGTCTGCAGCGAATGTTTGCC	0.463000													35	135					0	0	1	0	0
IL26	55801	broad.mit.edu	37	12	68619245	68619245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:68619245C>T	ENST00000229134.4	-	2	271	c.207G>A	c.(205-207)aaG>aaA	p.K69K	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	69					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTTTTGTTTTCTTTTTTAATA	0.279000													9	36					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85715876	85715876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85715876G>A	ENST00000322366.6	-	21	3690	c.3283C>T	c.(3283-3285)Cct>Tct	p.P1095S	WDFY3_ENST00000295888.4_Missense_Mutation_p.P1095S			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1095						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GAGGGAGGAGGGAAGAATCTT	0.343000													16	41					0	0	1	0	0
HAS1	3036	broad.mit.edu	37	19	52220383	52220383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52220383C>T	ENST00000540069.2	-	3	823	c.763G>A	c.(763-765)Gag>Aag	p.E255K	HAS1_ENST00000594621.1_Missense_Mutation_p.E110K|HAS1_ENST00000222115.1_Missense_Mutation_p.E256K|HAS1_ENST00000601714.1_Missense_Mutation_p.E263K			Q92839	HAS1_HUMAN	hyaluronan synthase 1	256					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CGGGGGTCCTCGTCCAGTACC	0.622000													30	89					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31914886	31914886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31914886G>A	ENST00000456570.1	+	15	1962	c.1907G>A	c.(1906-1908)gGt>gAt	p.G636D	CFB_ENST00000425368.2_Missense_Mutation_p.G134D|CFB_ENST00000477310.1_Missense_Mutation_p.G485D|CFB_ENST00000556679.1_Missense_Mutation_p.G636D			P00751	CFAB_HUMAN	complement factor B	134	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TGCTATGACGGTTACACTCTC	0.557000													33	82					0	0	1	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280812	105280812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105280812G>A	ENST00000327674.4	-	1	573	c.238C>T	c.(238-240)Ctt>Ttt	p.L80F	SERPINA7_ENST00000372563.1_Missense_Mutation_p.L80F			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	80					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	CCAAAGGAAAGCATAACCAAA	0.498000													30	30					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40916996	40916996	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40916996C>T	ENST00000346991.5	+	11	5002	c.4612C>T	c.(4612-4614)Caa>Taa	p.Q1538*	CASC5_ENST00000399668.2_Nonsense_Mutation_p.Q1512*			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1538					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		GGAAAATATTCAAACAACTAA	0.383000													19	35					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16638370	16638370	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:16638370C>T	ENST00000443444.2	+	12	2925	c.2785C>T	c.(2785-2787)Caa>Taa	p.Q929*	CCDC144A_ENST00000360524.8_Nonsense_Mutation_p.Q929*|CCDC144A_ENST00000399273.1_Nonsense_Mutation_p.Q929*|RP11-219A15.1_ENST00000448331.3_Nonsense_Mutation_p.Q929*|CCDC144A_ENST00000456009.1_Nonsense_Mutation_p.Q649*			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	929																	TGACTGTGATCAAAGTCAGAC	0.408000													14	12					0	0	1	0	0
TMEM27	57393	broad.mit.edu	37	X	15657812	15657812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:15657812G>A	ENST00000380342.3	-	5	640	c.385C>T	c.(385-387)Cct>Tct	p.P129S		NM_020665.4	NP_065716.1	Q9HBJ8	TMM27_HUMAN	transmembrane protein 27	129					proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			endometrium(3)|lung(4)|ovary(1)	8	Hepatocellular(33;0.183)					AGTGTGGAAGGGATTTTTAAA	0.348000													58	52					0	0	1	0	0
NKAIN3	286183	broad.mit.edu	37	8	63659578	63659578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:63659578C>T	ENST00000523211.1	+	4	493	c.361C>T	c.(361-363)Ccc>Tcc	p.P121S	NKAIN3_ENST00000519049.1_3'UTR|NKAIN3_ENST00000328472.5_Missense_Mutation_p.P121S	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	121						integral to membrane|plasma membrane				kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				AGTGCTGCCTCCCTCAGCCCA	0.517000													13	23					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961398	1961398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1961398G>A	ENST00000217305.2	-	4	561	c.336C>T	c.(334-336)ctC>ctT	p.L112L	PDYN_ENST00000540134.1_Silent_p.L112L|PDYN_ENST00000539905.1_Silent_p.L112L|RP4-684O24.5_ENST00000446562.1_RNA	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	112					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGATACTTGGGAGAAACTTGC	0.552000													38	72					0	0	1	0	0
TAS2R42	353164	broad.mit.edu	37	12	11338854	11338854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11338854C>T	ENST00000334266.1	-	1	689	c.690G>A	c.(688-690)agG>agA	p.R230R		NM_181429.1	NP_852094.1	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	230					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(2)|lung(4)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			TCATGGCCCTCCTATGGGCCT	0.408000													23	98					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287712	16287712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:16287712C>T	ENST00000343518.6	-	1	225	c.174G>A	c.(172-174)agG>agA	p.R58R		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	58										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CCATCTTGCTCCTGAGTGTCT	0.607000													65	368					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57432321	57432321	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57432321G>A	ENST00000442789.2	-	18	1922	c.1635C>T	c.(1633-1635)tcC>tcT	p.S545S	MYO1A_ENST00000476795.1_5'UTR|MYO1A_ENST00000300119.3_Silent_p.S545S|MYO1A_ENST00000544473.1_Silent_p.S383S	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	545	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						CAGGAAACAAGGACCGAAGGA	0.532000													26	100					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42754805	42754805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42754805C>T	ENST00000310232.6	-	14	1805	c.1722G>A	c.(1720-1722)gtG>gtA	p.V574V		NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	574										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						TGCTCTCCTCCACCCTGGTGA	0.602000													11	116					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122769437	122769437	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122769437C>T	ENST00000194130.2	-	9	1070	c.1031_splice	c.e9+1	p.R344_splice	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	344						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	tttgtCTTACCTTATTGGCCC	0.413000													13	61					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111779604	111779604	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111779604G>A	ENST00000261726.6	+	21	3560	c.3406G>A	c.(3406-3408)Ggc>Agc	p.G1136S		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1136						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						ACGTCGCTATGGCCTCATCAG	0.642000													46	84					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1719914	1719914	+	Silent	SNP	C	C	T	rs150074892		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1719914C>T	ENST00000313871.3	+	5	1711	c.1515C>T	c.(1513-1515)gcC>gcT	p.A505A		NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	505					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						ACCCAGAGGCCGACGGCGCTC	0.716000													4	6					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248790279	248790279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248790279G>A	ENST00000330803.2	-	1	212	c.151C>T	c.(151-153)Cgc>Tgc	p.R51C		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGTGGAGGCGAGAGTCCACC	0.498000													25	78					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5485338	5485338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:5485338C>T	ENST00000345221.3	-	3	1047	c.493G>A	c.(493-495)Gac>Aac	p.D165N	NLRP1_ENST00000354411.3_Missense_Mutation_p.D165N|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000262467.5_Missense_Mutation_p.D165N|NLRP1_ENST00000577119.1_Missense_Mutation_p.D165N|NLRP1_ENST00000572272.1_Missense_Mutation_p.D165N|NLRP1_ENST00000269280.4_Missense_Mutation_p.D165N	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	165					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GACTCATGGTCTGGGGAGCTT	0.522000													8	18					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6055780	6055780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6055780G>A	ENST00000409021.3	-	13	2252	c.1803C>T	c.(1801-1803)ctC>ctT	p.L601L	JAKMIP1_ENST00000410077.2_Silent_p.L436L|JAKMIP1_ENST00000409831.1_Silent_p.L601L|JAKMIP1_ENST00000282924.5_Silent_p.L601L|JAKMIP1_ENST00000409371.3_Silent_p.L416L	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	601	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding	p.L601L(2)		NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTCTTACTTCGAGTTCTAGCA	0.403000													65	162					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10579331	10579331	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:10579331T>A	ENST00000334534.5	+	5	427	c.247T>A	c.(247-249)Ttt>Att	p.F83I		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		AGGTTATGGCTTTCAAATCAC	0.453000													8	58					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51957554	51957554	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51957554C>T	ENST00000321424.3	-	6	1230	c.1164G>A	c.(1162-1164)agG>agA	p.R388R	SIGLEC8_ENST00000430817.1_Silent_p.R279R|SIGLEC8_ENST00000340550.5_Silent_p.R295R	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	388			R -> G (in dbSNP:rs3829659).		cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CCGATTTCTTCCTGCAGGACC	0.587000													32	83					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220792011	220792011	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:220792011C>T	ENST00000402574.1	+	9	1420	c.418C>T	c.(418-420)Cgt>Tgt	p.R140C	MARK1_ENST00000366917.4_Missense_Mutation_p.R275C|MARK1_ENST00000366918.4_Missense_Mutation_p.R253C	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	275	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		AGGGAAGTACCGTATTCCCTT	0.353000													10	109					0	0	1	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113661321	113661321	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113661321C>T	ENST00000393544.2	+	0	1369																											TGAAGGAGTTCGTCTTTGATG	0.493000													63	69					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149840229	149840229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:149840229G>A	ENST00000435030.1	+	15	2033	c.1665G>A	c.(1663-1665)ttG>ttA	p.L555L	KIF5C_ENST00000414838.2_Silent_p.L460L|KIF5C_ENST00000397413.1_Silent_p.L323L|KIF5C_ENST00000464066.1_3'UTR			O60282	KIF5C_HUMAN	kinesin family member 5C	555					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		ATTTGCTGTTGAAAGATCTGG	0.453000													15	35					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63883877	63883877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63883877G>A	ENST00000246841.3	+	2	1181	c.138G>A	c.(136-138)acG>acA	p.T46T	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	18	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity	p.T46T(1)		breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CCTTCCTGACGGAGGTCATCG	0.637000													11	35					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943142	72943142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72943142G>A	ENST00000328801.4	+	6	1192	c.1192G>A	c.(1192-1194)Ggg>Agg	p.G398R		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	398						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					AGCCATACACGGGCTGGAGGA	0.607000													18	41					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228479639	228479639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228479639G>A	ENST00000570156.2	+	44	11741	c.11667G>A	c.(11665-11667)gaG>gaA	p.E3889E	OBSCN_ENST00000366707.4_Silent_p.E579E|OBSCN_ENST00000422127.1_Silent_p.E3460E|OBSCN_ENST00000359599.6_Silent_p.E2307E|OBSCN_ENST00000284548.11_Silent_p.E3460E|OBSCN_ENST00000366709.4_Silent_p.E579E	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2926					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGAATGAAGAGGCCGTGGAAG	0.587000													14	32					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14650966	14650966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14650966C>T	ENST00000544627.1	+	15	4116	c.3796C>T	c.(3796-3798)Cct>Tct	p.P1266S	ATF7IP_ENST00000536444.1_Missense_Mutation_p.P1257S|ATF7IP_ENST00000540793.1_Missense_Mutation_p.P1258S|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P1258S			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	1258	Interaction with MBD1.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TTTCTGTGATCCTCAGTCAAC	0.408000													52	288					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68947229	68947229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:68947229G>A	ENST00000456315.2	-	9	1943	c.1829C>T	c.(1828-1830)cCc>cTc	p.P610L	DEPDC1_ENST00000370966.5_Missense_Mutation_p.P326L|RP4-694A7.2_ENST00000425820.1_RNA	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	610	Interaction with ZNF224.				intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		ATTTGGTGGGGGAAGTAACAA	0.413000													14	21					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99013074	99013074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99013074C>T	ENST00000393504.1	+	8	1858	c.1441C>T	c.(1441-1443)Cgc>Tgc	p.R481C	CNGA3_ENST00000409937.1_Missense_Mutation_p.R485C|CNGA3_ENST00000436404.2_Missense_Mutation_p.R463C|CNGA3_ENST00000272602.2_Missense_Mutation_p.R481C	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	481					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						GAAGAAGGTTCGCATCTTCCA	0.567000													13	22					0	0	1	0	0
REM2	161253	broad.mit.edu	37	14	23353973	23353973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23353973G>A	ENST00000267396.4	+	2	317	c.194G>A	c.(193-195)cGa>cAa	p.R65Q	REM2_ENST00000536884.1_Missense_Mutation_p.R65Q	NM_173527.2	NP_775798.2	Q8IYK8	REM2_HUMAN	RAS (RAD and GEM)-like GTP binding 2	65					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			breast(1)|central_nervous_system(1)|large_intestine(2)|ovary(1)	5	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		GCCCCCAGACGAAGAGGCAGT	0.577000													24	42					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41439581	41439581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:41439581G>A	ENST00000301831.4	-	35	4129	c.3667C>T	c.(3667-3669)Ctc>Ttc	p.L1223F		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	1223							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		ATTCTTCTGAGAATCCTTAAC	0.478000													35	100					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64535205	64535205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64535205G>A	ENST00000377390.3	-	10	1517	c.1180C>T	c.(1180-1182)Ccc>Tcc	p.P394S	SF1_ENST00000334944.5_Missense_Mutation_p.P394S|SF1_ENST00000433274.2_Missense_Mutation_p.P368S|SF1_ENST00000377387.1_Missense_Mutation_p.P519S|SF1_ENST00000422298.2_Missense_Mutation_p.P279S|SF1_ENST00000227503.9_Missense_Mutation_p.P394S|SF1_ENST00000377394.3_Missense_Mutation_p.P394S	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	394	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						AAGCTGTGGGGGCCACCTCCG	0.647000											OREG0004010|OREG0021062	type=REGULATORY REGION|Gene=LOC476031|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	39					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10465203	10465203	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10465203G>A	ENST00000525621.1	-	19	3181	c.2700C>T	c.(2698-2700)atC>atT	p.I900I	TYK2_ENST00000264818.6_Silent_p.I900I|TYK2_ENST00000524462.1_Silent_p.I715I	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	900	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCAGATCTCGGATCTTTTTCA	0.557000													34	73					0	0	1	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047149	46047149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46047149G>A	ENST00000397911.3	+	1	110	c.61G>A	c.(61-63)Gac>Aac	p.D21N	TSPEAR_ENST00000323084.4_Intron|KRTAP10-9_ENST00000484861.1_3'UTR	NM_198690.2	NP_941963.2	P60411	KR109_HUMAN	keratin associated protein 10-9	21						keratin filament				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9						GCAGGTGGACGACTGCCCAGA	0.687000													39	75					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27458232	27458232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27458232C>T	ENST00000264705.4	+	24	4068	c.3906C>T	c.(3904-3906)gcC>gcT	p.A1302A	CAD_ENST00000403525.1_Silent_p.A1239A	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1302	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	ACCTCAAGGCCATGCTAAGCA	0.582000													44	88					0	0	1	0	0
SLC5A5	6528	broad.mit.edu	37	19	18004539	18004539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18004539C>T	ENST00000222248.3	+	15	2132	c.1785C>T	c.(1783-1785)ccC>ccT	p.P595P		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	595					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						AAGAACTCCCCACTGGAAACA	0.582000													10	32					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94983447	94983447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94983447C>T	ENST00000357742.4	+	17	2128	c.2128C>T	c.(2128-2130)Ccc>Tcc	p.P710S	MCTP2_ENST00000451018.3_Intron	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	710					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			ATATATGATCCCCTTGGCATT	0.413000													47	355					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31593296	31593296	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31593296G>A	ENST00000379416.3	-	18	1953	c.1905C>T	c.(1903-1905)ttC>ttT	p.F635F		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	635					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CAGCGGAAATGAAACAAACAA	0.438000													10	50					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637430	248637430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248637430C>T	ENST00000359594.2	+	1	804	c.779C>T	c.(778-780)tCc>tTc	p.S260F		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCGGTGCTTCCTTCTACACC	0.557000													103	363					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32498033	32498033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32498033G>A	ENST00000266088.4	+	13	1724	c.1474G>A	c.(1474-1476)Gga>Aga	p.G492R	SLC5A1_ENST00000543737.1_Missense_Mutation_p.G365R	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	492					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						ACTGATCCTAGGACTTCTGAT	0.483000													26	58					0	0	1	0	0
TTLL13P	440307	broad.mit.edu	37	15	90794047	90794047	+	Missense_Mutation	SNP	C	C	T	rs144811975		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90794047C>T	ENST00000561573.1	+	2	449	c.185C>T	c.(184-186)cCg>cTg	p.P62L	TTLL13_ENST00000438251.1_Missense_Mutation_p.P62L|TTLL13_ENST00000339615.5_Missense_Mutation_p.P62L																							ACAAAAATTCCGAAGAAAGTC	0.478000													103	139					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24823824	24823824	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:24823824C>T	ENST00000424834.2	+	5	2336	c.1863C>T	c.(1861-1863)gaC>gaT	p.D621D	SPATA13_ENST00000382108.3_Silent_p.D621D|SPATA13_ENST00000382095.4_5'UTR			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	0	C-terminal tail.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		TGGACGAGGACCCCCAGGCAA	0.607000													37	136					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29230478	29230478	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29230478C>T	ENST00000441381.1	+	0	79																											ACTCCTTATTCCTTAGTGGGA	0.413000													18	38					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983508	123983508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:123983508G>A	ENST00000306315.5	-	4	3004	c.2569C>T	c.(2569-2571)Cat>Tat	p.H857Y	ZNF608_ENST00000504926.1_Missense_Mutation_p.H430Y	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	857						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TTGTTGAGATGATCCTTTAAA	0.498000													22	169					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78778131	78778131	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78778131T>C	ENST00000258886.8	+	13	1807	c.1658T>C	c.(1657-1659)gTt>gCt	p.V553A		NM_004136.2	NP_004127.1	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	553							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AGTGGGATGGTTACACATTAC	0.403000													149	151					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58330267	58330267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58330267G>A	ENST00000371015.1	+	4	856	c.389G>A	c.(388-390)gGa>gAa	p.G130E	PHACTR3_ENST00000541461.1_Missense_Mutation_p.G89E|PHACTR3_ENST00000395636.2_Missense_Mutation_p.G89E|PHACTR3_ENST00000395639.4_Missense_Mutation_p.G89E|PHACTR3_ENST00000361300.4_Missense_Mutation_p.G89E|PHACTR3_ENST00000355648.4_Missense_Mutation_p.G89E|PHACTR3_ENST00000359926.3_Missense_Mutation_p.G127E	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	130						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			AACCCCGATGGAGGACCCCGA	0.577000													16	49					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50528136	50528136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50528136G>A	ENST00000267842.5	+	10	1938	c.1706G>A	c.(1705-1707)gGa>gAa	p.G569E	SLC27A2_ENST00000544960.1_Missense_Mutation_p.G334E|SLC27A2_ENST00000380902.4_Missense_Mutation_p.G516E	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	569					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GAGATCACTGGAACTTTTAAA	0.428000													17	149					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33632886	33632886	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33632886C>T	ENST00000374316.5	+	14	2365	c.1305C>T	c.(1303-1305)ccC>ccT	p.P435P	ITPR3_ENST00000605930.1_Silent_p.P435P			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	435					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						TGTCAGTGCCCGTGTCTGAGA	0.612000													25	123					0	0	1	0	0
STX4	6810	broad.mit.edu	37	16	31045633	31045633	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31045633C>T	ENST00000394998.1	+	4	556	c.213C>T	c.(211-213)ccC>ccT	p.P71P	STX4_ENST00000493902.1_3'UTR|STX4_ENST00000313843.3_Silent_p.P73P	NM_001272096.1	NP_001259025.1	Q12846	STX4_HUMAN	syntaxin 4	73					intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity			NS(2)|breast(1)|large_intestine(3)|lung(3)	9						TGGCCACGCCCCTTCCCGAGG	0.602000													41	74					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61562572	61562572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61562572C>T	ENST00000457692.1	+	4	576	c.243C>T	c.(241-243)ttC>ttT	p.F81F	SERPINB2_ENST00000482254.1_3'UTR|SERPINB2_ENST00000299502.4_Silent_p.F81F	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	81					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	GCTGTGGGTTCATGCAGCAGA	0.433000													70	135					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36869813	36869813	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36869813G>A	ENST00000301807.6	-	23	8978	c.7081C>T	c.(7081-7083)Cgg>Tgg	p.R2361W	TRANK1_ENST00000429976.2_Missense_Mutation_p.R2911W|TRANK1_ENST00000428977.2_Missense_Mutation_p.R2361W	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2911					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CTTCTAGGCCGAAGCTCACCA	0.443000													10	20					0	0	1	0	0
CLCN7	1186	broad.mit.edu	37	16	1497080	1497080	+	Missense_Mutation	SNP	G	G	A	rs140032494		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1497080G>A	ENST00000382745.4	-	24	2863	c.2258C>T	c.(2257-2259)tCg>tTg	p.S753L	CLCN7_ENST00000262318.8_Silent_p.V729V|CLCN7_ENST00000448525.1_Missense_Mutation_p.S729L	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	753	CBS 2.					integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				CCGTGGGAGCGACGCCTCCTG	0.716000													5	10					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60063501	60063501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:60063501G>A	ENST00000267484.5	-	9	2628	c.2293C>T	c.(2293-2295)Cag>Tag	p.Q765*	RTN1_ENST00000395090.1_Nonsense_Mutation_p.Q182*|RTN1_ENST00000557422.1_5'UTR|RTN1_ENST00000342503.4_Nonsense_Mutation_p.Q197*	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	765	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		ATTTTAGCCTGAATCCTAAAA	0.398000													32	83					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20649578	20649578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20649578G>A	ENST00000525748.1	+	9	1721	c.1448G>A	c.(1447-1449)gGa>gAa	p.G483E		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	483					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	GCTGCATGGGGAGGCCTGATC	0.473000													19	93					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57918040	57918040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57918040C>T	ENST00000574161.1	+	5	594	c.475C>T	c.(475-477)Cgt>Tgt	p.R159C	GCOM1_ENST00000396180.1_Missense_Mutation_p.R128C|GCOM1_ENST00000380560.2_Intron|GCOM1_ENST00000380561.2_Missense_Mutation_p.R128C|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Missense_Mutation_p.R159C|GCOM1_ENST00000572390.1_Missense_Mutation_p.R159C|MYZAP_ENST00000267853.5_Missense_Mutation_p.R159C|GCOM1_ENST00000587652.1_Missense_Mutation_p.R159C|MYZAP_ENST00000380565.4_Missense_Mutation_p.R159C|GCOM1_ENST00000380568.3_Missense_Mutation_p.R159C	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		159					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						TGCCCTGGATCGTTTTAATGC	0.483000													23	43					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35390870	35390870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35390870G>A	ENST00000426836.1	-	6	956	c.584C>T	c.(583-585)tCa>tTa	p.S195L	DSN1_ENST00000448110.1_Missense_Mutation_p.S179L|DSN1_ENST00000373740.3_Missense_Mutation_p.S123L|DSN1_ENST00000373734.4_Missense_Mutation_p.S88L|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000373745.3_Missense_Mutation_p.S195L|DSN1_ENST00000373750.4_Missense_Mutation_p.S195L	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	195					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TTACCCATTTGAATCTTCAAA	0.423000													13	41					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52790732	52790732	+	Missense_Mutation	SNP	C	C	T	rs142616498	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52790732C>T	ENST00000257974.2	-	6	1080	c.1003G>A	c.(1003-1005)Gag>Aag	p.E335K	RP3-416H24.4_ENST00000547174.1_RNA	NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	335	Coil 2.|Rod.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		TCCAGGATCTCGTTCTTACGG	0.557000													13	37					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661734	77661734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77661734C>T	ENST00000296043.6	+	5	3361	c.2408C>T	c.(2407-2409)tCt>tTt	p.S803F		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	803					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GTGGGCGGCTCTGGTTTTGGC	0.552000													21	65					0	0	1	0	0
ZNF280A	129025	broad.mit.edu	37	22	22868820	22868820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22868820G>A	ENST00000302097.3	-	2	1387	c.1135C>T	c.(1135-1137)Ctc>Ttc	p.L379F		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TGTTGTAAGAGGACCTGATCT	0.473000													9	144					0	0	1	0	0
CSNK1E	1454	broad.mit.edu	37	22	38690525	38690525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38690525G>A	ENST00000396832.1	-	8	1161	c.901C>T	c.(901-903)Ccc>Tcc	p.P301S	CSNK1E_ENST00000359867.3_Missense_Mutation_p.P301S|CSNK1E_ENST00000403904.1_Missense_Mutation_p.P301S|CSNK1E_ENST00000400206.2_Missense_Mutation_p.P301S	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	301					DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					ACATCCTCGGGATTCCGGGCT	0.692000													5	8					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97464925	97464925	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97464925C>T	ENST00000377075.2	+	4	1911	c.1813C>T	c.(1813-1815)Cga>Tga	p.R605*	CNNM4_ENST00000540067.1_Nonsense_Mutation_p.R92*|CNNM4_ENST00000496186.1_3'UTR	NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	605					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						CCTGTACACCCGAAATAAGCC	0.577000													21	79					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390532	8390532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8390532C>T	ENST00000471889.1	+	5	1364	c.979C>T	c.(979-981)Ccg>Tcg	p.P327S	SLC45A1_ENST00000481265.1_3'UTR|SLC45A1_ENST00000377479.2_Missense_Mutation_p.P361S|SLC45A1_ENST00000289877.8_Missense_Mutation_p.P327S			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	327					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CGACAGCCTCCCGTCGCACAC	0.711000													10	42					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92702991	92702991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92702991C>T	ENST00000257068.2	+	1	106	c.100C>T	c.(100-102)Cct>Tct	p.P34S		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	34					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CTCCAGGACCCCTCGACCTCC	0.716000													4	7					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915242	119915242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:119915242G>A	ENST00000331113.4	+	1	1521	c.556G>A	c.(556-558)Gtg>Atg	p.V186M		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	186					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GATGGCCCTGGTGTTCTACTA	0.577000													12	55					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96698514	96698514	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96698514G>A	ENST00000260682.6	+	1	87	c.75G>A	c.(73-75)ggG>ggA	p.G25G	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	25					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	AGAGCTCTGGGAGAGGAAAAC	0.453000													12	184					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385829	33385829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33385829G>A	ENST00000541274.1	-	5	615	c.166C>T	c.(166-168)Cgc>Tgc	p.R56C	AQP7_ENST00000377425.4_Silent_p.F130F|AQP7_ENST00000539936.1_Silent_p.F187F|AQP7_ENST00000537089.1_Silent_p.F95F			O14520	AQP7_HUMAN	aquaporin 7	294					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCGTGATGGCGAAGAGACACA	0.627000													9	68					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3723942	3723942	+	Missense_Mutation	SNP	G	G	C	rs146515319	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3723942G>C	ENST00000324932.7	-	23	3683	c.3263C>G	c.(3262-3264)cCg>cGg	p.P1088R	NUP98_ENST00000355260.3_Missense_Mutation_p.P1088R|NUP98_ENST00000359171.4_Missense_Mutation_p.P1088R	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1105					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TGTTTTCAACGGAACCTCAGG	0.512000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								14	41					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162683579	162683579	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:162683579G>A	ENST00000366898.1	-	3	492	c.390C>T	c.(388-390)gaC>gaT	p.D130D	PARK2_ENST00000366892.1_Silent_p.D130D|PARK2_ENST00000366894.1_Intron|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000366897.1_Silent_p.D130D|PARK2_ENST00000338468.3_5'UTR	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	130					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CTGGTGGTGAGTCCTTCCTGC	0.532000													27	37					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872882	55872882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55872882C>T	ENST00000313503.1	+	1	364	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R122C(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					GGCCCATGATCGCTATGCAGC	0.458000										HNSCC(53;0.14)			67	256					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30887889	30887889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30887889C>T	ENST00000392772.2	-	10	958	c.681G>A	c.(679-681)acG>acA	p.T227T	SEC14L4_ENST00000540456.1_Silent_p.T266T|SEC14L4_ENST00000381982.3_Silent_p.T281T|RP4-539M6.14_ENST00000442126.1_RNA|SEC14L4_ENST00000255858.7_Silent_p.T281T			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	281	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	CCACGGACCTCGTGTGCTCAT	0.622000													17	36					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742538	23742538	+	RNA	SNP	C	C	T	rs743353	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23742538C>T	ENST00000255890.4	-	0	671																											GGCCCACCCTCGGAGCACAGG	0.627000													4	18					0	0	1	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38413338	38413338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:38413338G>A	ENST00000377694.1	-	3	605	c.583C>T	c.(583-585)Cct>Tct	p.P195S		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	195	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		GTGCCCTCAGGGGACTTCGTG	0.577000													12	56					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115950740	115950740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:115950740G>A	ENST00000238256.3	-	13	1322	c.1205C>T	c.(1204-1206)cCt>cTt	p.P402L		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	402					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						AGTCACCACAGGCTGCCCACC	0.567000													8	77					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167293777	167293777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167293777C>T	ENST00000308378.3	-	4	720	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	WDR49_ENST00000479765.1_Missense_Mutation_p.E480K|WDR49_ENST00000453925.2_Missense_Mutation_p.E192K	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	139										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TTGCTGGCTTCACTTTTCATT	0.408000													69	158					0	0	1	0	0
PTGIR	5739	broad.mit.edu	37	19	47124807	47124807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47124807C>T	ENST00000291294.2	-	3	1024	c.891G>A	c.(889-891)aaG>aaA	p.K297K	PTGIR_ENST00000598865.1_Silent_p.K85K|PTGIR_ENST00000594275.1_Silent_p.K54K|PTGIR_ENST00000597185.1_Silent_p.K26K	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	297					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GGAAGACAGCCTTGCGGAAAA	0.632000													7	81					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810843	31810843	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:31810843G>A	ENST00000446923.2	+	7	2923	c.2532G>A	c.(2530-2532)gtG>gtA	p.V844V	ZEB1_ENST00000361642.5_Silent_p.V861V|ZEB1_ENST00000542815.3_Silent_p.V793V|ZEB1_ENST00000320985.10_Silent_p.V860V|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000560721.2_Silent_p.V840V	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	860					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CCTTGAAAGTGATCCAGCCAA	0.418000													23	53					0	0	1	0	0
HORMAD1	84072	broad.mit.edu	37	1	150672595	150672595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150672595C>T	ENST00000368993.2	-	14	1202	c.1097G>A	c.(1096-1098)gGg>gAg	p.G366E	HORMAD1_ENST00000322343.7_Missense_Mutation_p.G359E|HORMAD1_ENST00000361824.2_Missense_Mutation_p.G366E|HORMAD1_ENST00000368995.4_Missense_Mutation_p.G286E			Q86X24	HORM1_HUMAN	HORMA domain containing 1	366					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TACTATTCTCCCAGATTCATG	0.289000													8	39					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207140439	207140439	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207140439C>T	ENST00000324852.4	-	3	601	c.127G>A	c.(127-129)Gga>Aga	p.G43R	FCAMR_ENST00000450945.2_Missense_Mutation_p.G43R|FCAMR_ENST00000400962.3_Missense_Mutation_p.G43R	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	342						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						ATTTTCCATCCCGCCCTCCTG	0.527000													5	51					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135206752	135206752	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135206752G>T	ENST00000372169.2	-	8	1104	c.922C>A	c.(922-924)Ctt>Att	p.L308I	SETX_ENST00000393220.1_Missense_Mutation_p.L308I|SETX_ENST00000224140.5_Missense_Mutation_p.L308I			Q7Z333	SETX_HUMAN	senataxin	308					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GGATCCATAAGTTGACCCCAG	0.433000													16	62					4.14922e-12	4.16852e-12	1	1	0
C8orf34	116328	broad.mit.edu	37	8	69358714	69358714	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:69358714C>T	ENST00000523686.1	+	3	417	c.368C>T	c.(367-369)tCa>tTa	p.S123L	C8orf34_ENST00000348340.2_Intron|C8orf34_ENST00000337103.4_Intron|C8orf34_ENST00000539993.1_Intron|C8orf34_ENST00000518698.1_Intron|C8orf34_ENST00000349492.3_Intron			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	450					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			GTCTCTTATTCAAATGCTATT	0.328000													14	40					0	0	1	0	0
C9orf84	158401	broad.mit.edu	37	9	114503831	114503831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114503831C>T	ENST00000394779.3	-	7	1034	c.790G>A	c.(790-792)Gaa>Aaa	p.E264K	C9orf84_ENST00000374287.3_Missense_Mutation_p.E303K|C9orf84_ENST00000318737.4_Missense_Mutation_p.E303K|C9orf84_ENST00000374283.5_Missense_Mutation_p.E367K|C9orf84_ENST00000394777.4_Missense_Mutation_p.E264K	NM_001080551.1	NP_001074020.1	Q5VXU9	CI084_HUMAN	chromosome 9 open reading frame 84	303										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTAGCTGATTCTTCAGCAGTA	0.254000													21	55					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23862712	23862712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23862712C>T	ENST00000405093.3	-	23	3014	c.2944G>A	c.(2944-2946)Gag>Aag	p.E982K	MYH6_ENST00000356287.3_Missense_Mutation_p.E982K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	982					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCCATCTCCTCTGTTAGGTTC	0.532000													93	205					0	0	1	0	0
CLU	1191	broad.mit.edu	37	8	27457323	27457323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27457323C>T	ENST00000316403.10	-	7	1543	c.1138G>A	c.(1138-1140)Gac>Aac	p.D380N	CLU_ENST00000405140.3_Missense_Mutation_p.D380N|CLU_ENST00000523500.1_Missense_Mutation_p.D380N|CLU_ENST00000560366.1_Missense_Mutation_p.D432N|CLU_ENST00000546343.1_Missense_Mutation_p.D391N			P10909	CLUS_HUMAN	clusterin	380					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TAGTACTGGTCTTCGCCTTGC	0.602000													3	19					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115375563	115375563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115375563C>T	ENST00000369358.4	-	27	3254	c.3010G>A	c.(3010-3012)Gaa>Aaa	p.E1004K	NRAP_ENST00000360478.3_Missense_Mutation_p.E961K|NRAP_ENST00000369360.3_Missense_Mutation_p.E969K|NRAP_ENST00000359988.3_Missense_Mutation_p.E996K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	996						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TCTCCTTGTTCCCTGTATAAT	0.493000													8	18					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41759219	41759219	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:41759219C>T	ENST00000301831.4	-	23	2918		c.e23+1			NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4								ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CTCCAATTTACCCAGGATTCG	0.453000													19	68					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411529	126411529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126411529C>T	ENST00000394329.3	+	17	13565	c.13552C>T	c.(13552-13554)Ctc>Ttc	p.L4518F	FAT4_ENST00000335110.5_Missense_Mutation_p.L2759F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4518					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CGTCTTGGCCCTCCTGGTCCT	0.557000													21	45					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136661589	136661589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136661589G>A	ENST00000371851.1	-	10	1304	c.979C>T	c.(979-981)Ccc>Tcc	p.P327S	VAV2_ENST00000406606.3_Missense_Mutation_p.P327S|VAV2_ENST00000371850.3_Missense_Mutation_p.P332S			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	332	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CTCTGCATGGGGACCACCAGC	0.612000													7	29					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44555716	44555716	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44555716C>T	ENST00000289547.4	-	18	3736	c.3681G>A	c.(3679-3681)agG>agA	p.R1227R	NPC1L1_ENST00000381160.3_Silent_p.R1200R|NPC1L1_ENST00000546276.1_Silent_p.R1154R	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1227					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	CCTCTTTGGCCCTCTCCAGCC	0.627000													6	11					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49006253	49006253	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49006253C>T	ENST00000600059.1	-	6	785	c.557_splice	c.e6-1	p.R186_splice	LMTK3_ENST00000270238.3_Splice_Site_p.R215_splice					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GCTGCAGGCTCCTGTGGAGTG	0.587000													4	28					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	57003538	57003538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57003538G>A	ENST00000200676.3	+	4	514	c.384G>A	c.(382-384)caG>caA	p.Q128Q	CETP_ENST00000379780.2_Silent_p.Q128Q|CETP_ENST00000569082.1_3'UTR|CETP_ENST00000566128.1_Silent_p.Q63Q	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	128					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						GTATTGATCAGTCCATTGACT	0.572000													10	78					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31040194	31040194	+	Missense_Mutation	SNP	C	C	T	rs142812385		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:31040194C>T	ENST00000355537.3	+	4	3815	c.3668C>T	c.(3667-3669)tCa>tTa	p.S1223L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGACTGGTCTCACCTTTATCC	0.662000													26	42					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37603235	37603235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37603235C>T	ENST00000399151.3	+	14	2238	c.2153C>T	c.(2152-2154)tCg>tTg	p.S718L		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	718					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CCATCGTCTTCGCCCAGCAGC	0.552000													20	44					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75508211	75508211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75508211C>T	ENST00000228027.7	+	6	903	c.643C>T	c.(643-645)Cct>Tct	p.P215S	DGAT2_ENST00000376262.3_Missense_Mutation_p.P172S	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	215					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					AGGTATCTGCCCTGTCAGCCG	0.542000													47	101					0	0	1	0	0
APCS	325	broad.mit.edu	37	1	159558247	159558247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159558247G>A	ENST00000255040.2	+	2	518	c.421G>A	c.(421-423)Ggt>Agt	p.G141S		NM_001639.3	NP_001630.1	P02743	SAMP_HUMAN	amyloid P component, serum	141	Pentaxin.		G -> S (in a breast cancer sample; somatic mutation).		acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding	p.G141S(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_hematologic(112;0.0429)					TCTGCGACAGGGTTACTTTGT	0.517000													10	50					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278458	50278458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:50278458C>T	ENST00000442544.2	+	2	742	c.126C>T	c.(124-126)ttC>ttT	p.F42F		NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	42	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CACTGCGCTTCCTCTCAGAAC	0.483000													15	44					0	0	1	0	0
AARD	441376	broad.mit.edu	37	8	117950651	117950651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:117950651G>A	ENST00000378279.3	+	1	214	c.169G>A	c.(169-171)Gag>Aag	p.E57K		NM_001025357.2	NP_001020528.1	Q4LEZ3	AARD_HUMAN	alanine and arginine rich domain containing protein	57																	CCCGCTGCTGGAGGACCTCAG	0.741000													7	20					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27169628	27169628	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27169628G>A	ENST00000380036.4	+	4	1070		c.e4+1		TEK_ENST00000519097.1_Splice_Site|TEK_ENST00000406359.4_Splice_Site	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial						angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ATAGTCCGGAGTAAGTGATGG	0.478000													28	59					0	0	1	0	0
TWSG1	57045	broad.mit.edu	37	18	9396289	9396289	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:9396289C>T	ENST00000262120.5	+	4	426	c.235C>T	c.(235-237)Cct>Tct	p.P79S	TWSG1_ENST00000581641.1_Missense_Mutation_p.P79S	NM_020648.5	NP_065699.1	Q9GZX9	TWSG1_HUMAN	twisted gastrulation BMP signaling modulator 1	79										breast(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|pancreas(2)	10						TATGTGTAATCCTCGAAATTA	0.418000													16	53					0	0	1	0	0
TRAV8-3	28683	broad.mit.edu	37	14	22321054	22321054	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22321054C>T	ENST00000390435.1	+	0	212																											AAGTACTTTTCAGGAGACACT	0.478000													9	27					0	0	1	0	0
CD19	930	broad.mit.edu	37	16	28944296	28944296	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28944296C>T	ENST00000538922.1	+	3	482	c.420C>T	c.(418-420)tcC>tcT	p.S140S	CD19_ENST00000567541.1_Silent_p.S140S|CD19_ENST00000324662.3_Silent_p.S140S	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	140					cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						AGAACAGGTCCTCAGAGGGCC	0.617000													3	14					0	0	1	0	0
RFPL1	5988	broad.mit.edu	37	22	29837733	29837733	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29837733G>A	ENST00000354373.2	+	2	785	c.576G>A	c.(574-576)tgG>tgA	p.W192*	RFPL1S_ENST00000539579.1_RNA|RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	192	B30.2/SPRY.						zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						GCACAGAATGGGACCTGGGAG	0.567000													44	129					0	0	1	0	0
KRTAP10-7	386675	broad.mit.edu	37	21	46021459	46021459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46021459C>T	ENST00000380102.2	+	1	963	c.938C>T	c.(937-939)tCc>tTc	p.S313F	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	313	30 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						CCCTCCTCCTCCGTGTCCCTC	0.692000													10	118					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30398934	30398934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30398934G>A	ENST00000333027.3	+	9	951	c.623G>A	c.(622-624)aGt>aAt	p.S208N	MTMR3_ENST00000401950.2_Missense_Mutation_p.S208N|MTMR3_ENST00000351488.3_Missense_Mutation_p.S208N|MTMR3_ENST00000323630.5_Missense_Mutation_p.S72N|MTMR3_ENST00000406629.1_Missense_Mutation_p.S208N	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	208	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			GAACTGGAAAGTGTATCAAGT	0.507000													37	77					0	0	1	0	0
LHFPL1	340596	broad.mit.edu	37	X	111914257	111914257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:111914257C>T	ENST00000371968.3	-	2	601	c.362G>A	c.(361-363)gGa>gAa	p.G121E	LHFPL1_ENST00000536453.1_Missense_Mutation_p.G121E|LHFPL1_ENST00000478229.1_Intron	NM_178175.3	NP_835469.1	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1	121						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)	13						CTGCGCTGCTCCCATGCAACG	0.577000													26	14					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183895291	183895291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183895291G>A	ENST00000304685.3	+	19	2738	c.2277G>A	c.(2275-2277)gtG>gtA	p.V759V	RGL1_ENST00000360851.3_Silent_p.V724V|RGL1_ENST00000367531.1_Silent_p.V759V|RGL1_ENST00000539189.1_Silent_p.V695V|RGL1_ENST00000536277.1_Silent_p.V722V	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	724					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						ACAGCCAAGTGAACTTTGACT	0.453000													45	124					0	0	1	0	0
SIX1	6495	broad.mit.edu	37	14	61115508	61115508	+	Missense_Mutation	SNP	T	T	C	rs80356460		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:61115508T>C	ENST00000247182.6	-	1	672	c.400A>G	c.(400-402)Aag>Gag	p.K134E	SIX1_ENST00000554986.1_Intron	NM_005982.3	NP_005973.1	Q15475	SIX1_HUMAN	SIX homeobox 1	134					branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		CCCCTCGACTTCTCCTTGAAG	0.662000													31	55					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31533801	31533801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31533801G>A	ENST00000215885.3	-	4	1213	c.961C>T	c.(961-963)Ccc>Tcc	p.P321S		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	321					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						GCTTTGCTGGGGCGCTTGGAC	0.652000													69	162					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066331	9066331	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9066331A>T	ENST00000397910.4	-	3	21318	c.21115T>A	c.(21115-21117)Tct>Act	p.S7039T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7041	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGAGGTAGACCCAGAAGGA	0.483000													52	140					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69669255	69669255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69669255C>T	ENST00000194900.4	+	4	850	c.509C>T	c.(508-510)cCc>cTc	p.P170L	DLG3_ENST00000374360.3_Missense_Mutation_p.P152L			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	152	PDZ 1.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					ATCGACAATCCCCATGTCCCT	0.567000													29	20					0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77456024	77456024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:77456024C>T	ENST00000299543.7	+	3	593	c.446C>T	c.(445-447)aCc>aTc	p.T149I	CTDP1_ENST00000075430.7_Missense_Mutation_p.T149I	NM_001202504.1|NM_004715.4	NP_001189433.1|NP_004706.3	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	149					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		TCCACGGCGACCGTGTCCATG	0.622000													10	27					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77702316	77702316	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:77702316G>A	ENST00000534064.1	-	2	118	c.84C>T	c.(82-84)ctC>ctT	p.L28L	INTS4_ENST00000527522.1_Silent_p.L28L|INTS4_ENST00000529807.1_Silent_p.L28L	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	28					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TTGTTAGTCGGAGTTTCTTAG	0.428000													42	92					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153884264	153884264	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:153884264C>T	ENST00000511601.1	+	8	1199	c.1011C>T	c.(1009-1011)ctC>ctT	p.L337L	FHDC1_ENST00000260008.3_Silent_p.L337L			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	337	FH2.				actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GGATGAATCTCCTGCACTTTG	0.438000													48	99					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50324451	50324451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50324451C>T	ENST00000394697.2	+	3	595	c.255C>T	c.(253-255)gtC>gtT	p.V85V	ADCY7_ENST00000537579.1_Silent_p.V85V|ADCY7_ENST00000566433.2_Silent_p.V85V|ADCY7_ENST00000564044.1_Intron|ADCY7_ENST00000538642.1_Silent_p.V85V|ADCY7_ENST00000254235.3_Silent_p.V85V			P51828	ADCY7_HUMAN	adenylate cyclase 7	85					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TGATGTACGTCGAGTGTCTCC	0.642000													29	52					0	0	1	0	0
STAC3	246329	broad.mit.edu	37	12	57643365	57643365	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57643365G>A	ENST00000332782.2	-	2	256	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W	STAC3_ENST00000554578.1_Intron|STAC3_ENST00000546246.2_Intron	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	19					intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						CCACTTTGCCGAGTCTCTGCT	0.522000													27	67					0	0	1	0	0
CHAT	1103	broad.mit.edu	37	10	50857597	50857597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50857597G>A	ENST00000395562.2	+	11	1649	c.1180G>A	c.(1180-1182)Gag>Aag	p.E394K	CHAT_ENST00000351556.3_Missense_Mutation_p.E358K|CHAT_ENST00000455728.2_Missense_Mutation_p.E358K|CHAT_ENST00000395559.2_Missense_Mutation_p.E358K|CHAT_ENST00000339797.1_Missense_Mutation_p.E358K|CHAT_ENST00000337653.2_Missense_Mutation_p.E476K	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	476					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CTCCGTCAGCGAGCTCCCCGC	0.617000													16	68					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28755047	28755047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:28755047C>T	ENST00000422425.2	+	9	585	c.541C>T	c.(541-543)Ccc>Tcc	p.P181S	PLB1_ENST00000327757.5_Missense_Mutation_p.P181S	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	181	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TTACCTGTGCCCCTCTGCTCA	0.478000													33	158					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134916263	134916263	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134916263G>A	ENST00000607359.1	+	14	2478	c.2478G>A	c.(2476-2478)agG>agA	p.R826R	GPR123_ENST00000392606.2_Silent_p.R9R|GPR123_ENST00000392607.3_Silent_p.R106R			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	106						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		TGACCGCCAGGAACATCTACA	0.622000													5	28					0	0	1	0	0
OR14I1	401994	broad.mit.edu	37	1	248845324	248845324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248845324G>A	ENST00000342623.3	-	1	305	c.282C>T	c.(280-282)ggC>ggT	p.G94G		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G94G(1)		NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						GAGCCACACAGCCAAGATAAG	0.488000													8	40					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145894735	145894735	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145894735C>T	ENST00000311104.2	-	1	1018	c.942G>A	c.(940-942)agG>agA	p.R314R		NM_194251.2	NP_919227.2	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	314						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAAGCCTTCCCTGAACTCTT	0.468000													10	45					0	0	1	0	0
CSTF1	1477	broad.mit.edu	37	20	54978716	54978716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:54978716C>T	ENST00000217109.4	+	6	1581	c.1229C>T	c.(1228-1230)cCc>cTc	p.P410L	CSTF1_ENST00000493039.1_3'UTR	NM_001033521.1|NM_001324.2	NP_001028693.1|NP_001315.1	Q05048	CSTF1_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa	410					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	15			Colorectal(105;0.202)			CCCACCAACCCCGGGTTCATG	0.577000													30	98					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172504301	172504301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172504301C>T	ENST00000417960.1	+	18	2225	c.1748C>T	c.(1747-1749)gCt>gTt	p.A583V	ECT2_ENST00000540509.1_Missense_Mutation_p.A615V|ECT2_ENST00000232458.5_Missense_Mutation_p.A584V|ECT2_ENST00000441497.2_Missense_Mutation_p.A584V|ECT2_ENST00000427830.1_Missense_Mutation_p.A584V|ECT2_ENST00000392692.3_Missense_Mutation_p.A615V	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	584	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AAGCATACAGCTGATGAAAAT	0.318000													9	38					0	0	1	0	0
UIMC1	51720	broad.mit.edu	37	5	176378527	176378527	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176378527G>A	ENST00000377219.2	-	9	1557	c.1391C>T	c.(1390-1392)cCa>cTa	p.P464L	UIMC1_ENST00000511320.1_Missense_Mutation_p.P464L|UIMC1_ENST00000377227.4_Missense_Mutation_p.P464L|UIMC1_ENST00000506128.1_Missense_Mutation_p.P298L|UIMC1_ENST00000503273.1_5'UTR	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	464	Necessary for interaction with NR6A1 C- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTGCTACCTGGAGAGACTTC	0.353000													94	281					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54872769	54872769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54872769G>A	ENST00000391743.3	-	2	344	c.64C>T	c.(64-66)Ccc>Tcc	p.P22S	LAIR1_ENST00000391742.2_Missense_Mutation_p.P40S|LAIR1_ENST00000434277.2_Missense_Mutation_p.P39S|LAIR1_ENST00000313038.6_Missense_Mutation_p.P33S|LAIR1_ENST00000348231.4_Missense_Mutation_p.P40S|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000474878.1_Missense_Mutation_p.P39S			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	40						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		CTCCCCAGGGGGATCACGGTG	0.577000													54	151					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22915379	22915379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22915379C>T	ENST00000166244.3	+	5	1067	c.995C>T	c.(994-996)cCa>cTa	p.P332L	EPHA8_ENST00000374644.4_Missense_Mutation_p.P332L|EPHA8_ENST00000538803.1_Missense_Mutation_p.P332L	NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	332	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCCTCGGCACCAGTGAACCTG	0.587000													22	48					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238277483	238277483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238277483G>A	ENST00000295550.4	-	10	5075	c.4623C>T	c.(4621-4623)ccC>ccT	p.P1541P	COL6A3_ENST00000409809.1_Silent_p.P1335P|COL6A3_ENST00000472056.1_Silent_p.P934P|COL6A3_ENST00000346358.4_Silent_p.P1341P|COL6A3_ENST00000353578.4_Silent_p.P1335P|COL6A3_ENST00000347401.3_Silent_p.P1340P	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1541	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCAGGTGTTGGGGCACCCCGT	0.572000													40	88					0	0	1	0	0
FGF14	2259	broad.mit.edu	37	13	102378965	102378965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:102378965C>T	ENST00000376131.4	-	4	714	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	FGF14_ENST00000376143.4_Missense_Mutation_p.E202K	NM_175929.2	NP_787125.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	202					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TACTCACCTTCCAATGGCTTG	0.358000													12	121					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688164	60688164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:60688164G>A	ENST00000335712.6	-	4	2110	c.1883C>T	c.(1882-1884)tCg>tTg	p.S628L	BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Missense_Mutation_p.S594L|BCL11A_ENST00000537768.1_Missense_Mutation_p.S297L|BCL11A_ENST00000358510.4_Missense_Mutation_p.S594L|BCL11A_ENST00000356842.4_Missense_Mutation_p.S628L	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	628					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GGGGCTCAGCGAGCTGGGGCT	0.662000			T	IGH@	B-CLL								18	35					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74274418	74274418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74274418C>T	ENST00000295897.4	+	4	467	c.378C>T	c.(376-378)ttC>ttT	p.F126F	ALB_ENST00000503124.1_Intron|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000509063.1_Silent_p.F126F|ALB_ENST00000415165.2_Intron|ALB_ENST00000401494.3_Intron	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	126	Albumin 1.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	ATGAATGCTTCTTGCAACACA	0.423000													20	36					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61819614	61819614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61819614G>A	ENST00000373827.2	-	40	5059	c.4889C>T	c.(4888-4890)cCt>cTt	p.P1630L	ANK3_ENST00000503366.1_Missense_Mutation_p.P1637L|RP11-388P9.2_ENST00000414383.1_RNA|ANK3_ENST00000280772.1_Intron|ANK3_ENST00000355288.2_Missense_Mutation_p.P770L	NM_001204403.1	NP_001191332.1	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3687	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCCCTGGGAAGGCACTAGCCC	0.478000													29	125					0	0	1	0	0
NCALD	83988	broad.mit.edu	37	8	102731543	102731543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:102731543G>A	ENST00000395923.1	-	4	774	c.315C>T	c.(313-315)ttC>ttT	p.F105F	NCALD_ENST00000220931.6_Silent_p.F105F|NCALD_ENST00000522951.1_Silent_p.F105F|NCALD_ENST00000521599.1_Silent_p.F105F|NCALD_ENST00000519508.2_Silent_p.F105F|NCALD_ENST00000311028.3_Silent_p.F105F	NM_001040627.1|NM_001040628.1|NM_001040629.1|NM_001040630.1	NP_001035717.1|NP_001035718.1|NP_001035719.1|NP_001035720.1	P61601	NCALD_HUMAN	neurocalcin delta	105	EF-hand 3.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)	8	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			CGTACATGCTGAAGGCCCATT	0.478000													47	134					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11186751	11186751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11186751G>A	ENST00000361445.4	-	46	6530	c.6454C>T	c.(6454-6456)Cgc>Tgc	p.R2152C	MTOR_ENST00000376838.1_Missense_Mutation_p.R357C	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2152					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GACTGAATGCGAATGATTGGC	0.493000													34	74					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167301376	167301376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167301376C>T	ENST00000409855.1	-	12	1648	c.1522G>A	c.(1522-1524)Gat>Aat	p.D508N		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	508					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						AGGAAAAGATCAGTAAATGGT	0.328000													12	31					0	0	1	0	0
TMC6	11322	broad.mit.edu	37	17	76118722	76118722	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76118722G>A	ENST00000590602.1	-	10	1350	c.1191C>T	c.(1189-1191)tcC>tcT	p.S397S	TMC6_ENST00000322933.4_Silent_p.S36S|TMC6_ENST00000306591.7_Silent_p.S397S|TMC6_ENST00000591436.1_Silent_p.S36S|TMC6_ENST00000589553.1_Silent_p.S170S|TMC6_ENST00000392467.3_Silent_p.S397S|TMC6_ENST00000322914.3_Silent_p.S397S|TMC6_ENST00000592076.1_5'UTR			Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	397						endoplasmic reticulum membrane|integral to membrane				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	14			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GCTGGAGGCGGGAGGCCCGCT	0.662000													6	18					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130763803	130763803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:130763803C>T	ENST00000276708.4	-	10	1809	c.928G>A	c.(928-930)Gaa>Aaa	p.E310K		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	310						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CAGAAGGGTTCCTCTATTCTT	0.478000													33	80					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18702854	18702854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18702854G>A	ENST00000251296.1	+	7	1449	c.1066G>A	c.(1066-1068)Ggg>Agg	p.G356R	IGSF21_ENST00000473951.1_3'UTR	NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	356	Ig-like 2.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		AGCCCGGGTAGGGGACACAGT	0.587000													61	189					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169337945	169337945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169337945G>A	ENST00000511577.1	-	20	2861	c.2614C>T	c.(2614-2616)Cat>Tat	p.H872Y	DDX60L_ENST00000505890.1_Missense_Mutation_p.H872Y|DDX60L_ENST00000260184.7_Missense_Mutation_p.H872Y			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	872	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CCAAGATAATGGACCTAGTAA	0.328000													14	57					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183014925	183014925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183014925G>A	ENST00000328913.3	-	12	1633	c.1336C>T	c.(1336-1338)Ctc>Ttc	p.L446F	MCF2L2_ENST00000447025.2_Missense_Mutation_p.L446F|MCF2L2_ENST00000473233.1_Missense_Mutation_p.L446F|MCF2L2_ENST00000414362.2_Missense_Mutation_p.L446F|B3GNT5_ENST00000462559.1_3'UTR	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	446					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.L446I(1)		breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GAAGCCAAGAGGTAGATTCCT	0.532000													12	64					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48755478	48755478	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48755478C>T	ENST00000285238.8	+	25	3683	c.3603C>T	c.(3601-3603)ttC>ttT	p.F1201F		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1201	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GAGTGGAGTTCGTGGGGAACT	0.602000													55	55					0	0	1	0	0
GIPC1	10755	broad.mit.edu	37	19	14593559	14593559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14593559G>A	ENST00000393033.4	-	4	499	c.230C>T	c.(229-231)aCc>aTc	p.T77I	GIPC1_ENST00000345425.2_Missense_Mutation_p.T77I|GIPC1_ENST00000591349.1_Intron|GIPC1_ENST00000393028.1_Intron|GIPC1_ENST00000393029.3_Intron|GIPC1_ENST00000586027.1_Missense_Mutation_p.T77I	NM_005716.3	NP_005707.1	O14908	GIPC1_HUMAN	GIPC PDZ domain containing family, member 1	77					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						CTTGACGTTGGTGAAGCCCTC	0.677000													9	25					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538718	55538718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55538718G>A	ENST00000220676.1	+	4	2424	c.2276G>A	c.(2275-2277)aGa>aAa	p.R759K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	759					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AATTTCCATAGAAATAAATTA	0.299000													9	29					0	0	1	0	0
MIP	4284	broad.mit.edu	37	12	56847402	56847402	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56847402G>A	ENST00000257979.4	-	2	526	c.498C>T	c.(496-498)ttC>ttT	p.F166F	MIP_ENST00000555551.1_5'UTR	NM_012064.3	NP_036196.1	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	166					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	16						GGGCAAGGGAGAAGCCAACGG	0.567000													27	62					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15885110	15885110	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15885110G>A	ENST00000587443.2	-	0	312					NR_033864.1																						AGGGCTTCAGGAACCTGATGG	0.577000													44	83					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100796698	100796698	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:100796698C>T	ENST00000358544.2	+	43	8121	c.8010C>T	c.(8008-8010)tcC>tcT	p.S2670S	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Silent_p.S2645S	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2670					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTCACAAATCCCCACAGGTAT	0.468000													25	105					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24454272	24454272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24454272C>T	ENST00000230036.1	-	14	1416	c.1306G>A	c.(1306-1308)Gag>Aag	p.E436K		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	436						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						CTGTGGGCCTCCTTGTCCAGG	0.562000													7	112					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34235964	34235964	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34235964G>A	ENST00000587132.1	-	0	2063																											TTTGGATGCTGAGCCTGGTTC	0.478000													26	38					0	0	1	0	0
LYPD3	27076	broad.mit.edu	37	19	43965559	43965559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43965559G>A	ENST00000244333.3	-	5	1073	c.985C>T	c.(985-987)Ccc>Tcc	p.P329S		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	329						anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				CCAGCTGTGGGAGCCACACAG	0.602000													12	29					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54793667	54793667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54793667G>A	ENST00000293379.4	-	26	2969	c.2708C>T	c.(2707-2709)tCc>tTc	p.S903F	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	903					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						AGGTCCCGAGGAAGCAGAGCT	0.552000											OREG0021897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	120					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18039118	18039118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18039118G>A	ENST00000205890.5	+	13	4914	c.4576G>A	c.(4576-4578)Gcc>Acc	p.A1526T		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1526	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CCTGCAGAAGGCCATCACCTT	0.592000													4	22					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6635479	6635479	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6635479C>T	ENST00000315579.5	+	20	3307	c.2508C>T	c.(2506-2508)ccC>ccT	p.P836P	NCAPD2_ENST00000545962.1_Silent_p.P791P|NCAPD2_ENST00000542492.1_3'UTR	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	836					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						GTCACCCCCCCTTCCGGCTGC	0.567000													34	73					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15063777	15063777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15063777C>T	ENST00000430939.2	-	8	1399	c.1270G>A	c.(1270-1272)Gaa>Aaa	p.E424K	SLC1A6_ENST00000221742.3_Missense_Mutation_p.E488K|SLC1A6_ENST00000600144.1_Missense_Mutation_p.E410K			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	488					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	GTGATGTCTTCCGTGGGCAAG	0.602000													52	116					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118506066	118506066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:118506066C>T	ENST00000311085.8	+	24	5660	c.5580C>T	c.(5578-5580)acC>acT	p.T1860T	DMXL1_ENST00000539542.1_Silent_p.T1860T	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1860										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TATTTTTTACCACTGCCAGTG	0.368000													11	41					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45281206	45281206	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45281206C>T	ENST00000270279.3	+	1	81	c.18C>T	c.(16-18)gcC>gcT	p.A6A	CBLC_ENST00000341505.4_Silent_p.A6A	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	6					cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				TGGCGGTGGCCCCGTGGGGGC	0.716000			M		AML								9	15					0	0	1	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135758808	135758808	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135758808C>T	ENST00000250617.6	-	18	3125	c.1920G>A	c.(1918-1920)tcG>tcA	p.S640S	ARHGEF6_ENST00000370622.1_Silent_p.S486S|ARHGEF6_ENST00000535227.1_Silent_p.S513S|ARHGEF6_ENST00000370620.1_Silent_p.S486S	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	640					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.S640S(1)		cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					ATTCCTCCTCCGATGGTTTTC	0.323000													22	11					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91469768	91469768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:91469768C>T	ENST00000416354.1	+	5	508	c.436C>T	c.(436-438)Cgt>Tgt	p.R146C	KIF20B_ENST00000394289.2_Missense_Mutation_p.R146C|KIF20B_ENST00000371728.3_Missense_Mutation_p.R146C|KIF20B_ENST00000260753.4_Missense_Mutation_p.R146C			Q96Q89	KI20B_HUMAN	kinesin family member 20B	146	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						AGGACAGAGTCGTCTGATTTT	0.353000													58	105					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196749452	196749452	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196749452G>A	ENST00000312428.6	-	35	5720	c.5620C>T	c.(5620-5622)Cga>Tga	p.R1874*		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1874					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATTAGTTCTCGAAGAATCTTA	0.383000													28	51					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62329940	62329940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62329940G>A	ENST00000371158.2	+	20	2584	c.2470G>A	c.(2470-2472)Gaa>Aaa	p.E824K	INADL_ENST00000316485.6_Missense_Mutation_p.E824K	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	824					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TTTTAAAGAAGAACTTGTGGA	0.373000													15	75					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9864374	9864374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:9864374C>T	ENST00000380913.3	+	4	2516	c.2426C>T	c.(2425-2427)cCc>cTc	p.P809L		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	809					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				AAACCTGTTCCCCAGAGGCCT	0.602000													31	13					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435691	158435691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158435691C>T	ENST00000289451.2	+	1	420	c.340C>T	c.(340-342)Ctg>Ttg	p.L114L		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TCACTCCTTCCTGCTGGCAGC	0.527000													38	176					0	0	1	0	0
RAX	30062	broad.mit.edu	37	18	56939816	56939816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56939816C>T	ENST00000334889.3	-	2	506	c.320G>A	c.(319-321)gGg>gAg	p.G107E	RAX_ENST00000256852.7_Intron	NM_013435.2	NP_038463.2	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	107				G -> W (in Ref. 1; AAD23438).	visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)		CCGTGCCTCCCCGGGCTCCTT	0.701000													16	56					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088013	86088013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:86088013G>A	ENST00000330753.4	+	2	922	c.155G>A	c.(154-156)cGa>cAa	p.R52Q	FLRT2_ENST00000554746.1_Missense_Mutation_p.R52Q	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	52	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGTAATGAGCGAAGCTTGACC	0.517000													45	103					0	0	1	0	0
LRRC4B	94030	broad.mit.edu	37	19	51020884	51020884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51020884C>T	ENST00000599957.1	-	3	2283	c.2086G>A	c.(2086-2088)Gaa>Aaa	p.E696K	LRRC4B_ENST00000389201.3_Missense_Mutation_p.E696K			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	696						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AGCAGAGGTTCGTGGATGGAG	0.697000													10	25					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153554	5153554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5153554G>A	ENST00000307388.1	-	1	318	c.319C>T	c.(319-321)Cac>Tac	p.H107Y		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGAATGAGTGAATAAGCCAC	0.448000													6	56					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141473643	141473643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141473643G>A	ENST00000389484.3	-	37	6893	c.5922C>T	c.(5920-5922)ttC>ttT	p.F1974F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1974					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAATTAAGTTGAAACCATGAT	0.333000										TSP Lung(27;0.18)			36	116					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118203949	118203949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118203949C>T	ENST00000369230.3	+	4	526	c.380C>T	c.(379-381)tCa>tTa	p.S127L		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	127					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		ATCAACGGTTCACGGGAATAC	0.333000													43	69					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174230	51174230	+	Missense_Mutation	SNP	G	G	A	rs61731136	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51174230G>A	ENST00000440970.1	-	2	2043	c.1612C>T	c.(1612-1614)Ccg>Tcg	p.P538S	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.P635S|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	635					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTCGCCGTCGGGACTGAGTTG	0.632000													24	47					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670757	131670757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131670757C>T	ENST00000259324.5	+	3	1837	c.1314C>T	c.(1312-1314)atC>atT	p.I438I	LRRC8A_ENST00000372599.3_Silent_p.I438I|LRRC8A_ENST00000372600.4_Silent_p.I438I	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	438					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						TCAGTGGCATCCCTGACACTG	0.612000													9	26					0	0	1	0	0
AMN	81693	broad.mit.edu	37	14	103396997	103396997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103396997G>A	ENST00000299155.5	+	12	1375	c.1342G>A	c.(1342-1344)Ggg>Agg	p.G448R		NM_030943.3	NP_112205.2	Q9BXJ7	AMNLS_HUMAN	amnion associated transmembrane protein	448					lipid metabolic process|lipoprotein metabolic process|multicellular organismal development	integral to membrane|plasma membrane				kidney(2)|large_intestine(1)|lung(2)|skin(1)	6				Colorectal(3;0.00739)|READ - Rectum adenocarcinoma(2;0.0336)|Epithelial(152;0.0363)|all cancers(159;0.147)	Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCTGTTCGCCGGGGCCGAGGC	0.716000													6	11					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9352995	9352995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9352995G>A	ENST00000378501.2	+	8	646	c.631G>A	c.(631-633)Gaa>Aaa	p.E211K	PLCB4_ENST00000414679.2_Missense_Mutation_p.E211K|PLCB4_ENST00000378493.1_Missense_Mutation_p.E211K|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.E211K|PLCB4_ENST00000378473.3_Missense_Mutation_p.E211K|PLCB4_ENST00000334005.3_Missense_Mutation_p.E211K	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	211					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AAAGTTCTATGAACTGACACA	0.338000													13	83					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70079799	70079799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70079799C>T	ENST00000446444.1	-	1	650	c.642G>A	c.(640-642)atG>atA	p.M214I	RP11-704M14.1_ENST00000505646.1_RNA|RP11-704M14.1_ENST00000504301.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	214					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						GCACATAGATCATATTTTTTA	0.343000													23	57					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8660990	8660990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8660990G>A	ENST00000270328.4	-	10	1570	c.1304C>T	c.(1303-1305)tCc>tTc	p.S435F	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.S435F			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	435	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						ACGGCTGCAGGATGACCACAC	0.597000													51	97					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7042193	7042193	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:7042193G>A	ENST00000389658.3	-	9	1305	c.1212C>T	c.(1210-1212)tcC>tcT	p.S404S		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	404	Laminin EGF-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGAACTGAGGGACCCCACAG	0.448000													10	30					0	0	1	0	0
C2orf43	60526	broad.mit.edu	37	2	20939734	20939734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:20939734G>A	ENST00000237822.3	-	5	779	c.700C>T	c.(700-702)Ctt>Ttt	p.L234F	C2orf43_ENST00000541941.1_Missense_Mutation_p.L104F|C2orf43_ENST00000403006.2_Missense_Mutation_p.L104F|C2orf43_ENST00000381090.3_Missense_Mutation_p.L234F|C2orf43_ENST00000435420.2_Missense_Mutation_p.L186F|C2orf43_ENST00000440866.2_Intron	NM_021925.2	NP_068744.1	Q9H6V9	CB043_HUMAN	chromosome 2 open reading frame 43	234										endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTTACCAAGGCAGAATGGT	0.348000													16	78					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219254613	219254613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219254613C>T	ENST00000233202.6	+	9	1156	c.816C>T	c.(814-816)gcC>gcT	p.A272A	SLC11A1_ENST00000539932.1_Silent_p.A154A	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	272					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGACCGGGCCCGCCGAGCAG	0.537000													15	26					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152433	18152433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18152433G>A	ENST00000375406.1	+	3	736	c.520G>A	c.(520-522)Gag>Aag	p.E174K		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	174						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CAAGACGCTGGAGTTCGCCGG	0.617000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	26					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65684548	65684548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65684548G>A	ENST00000352385.2	-	11	2255	c.2046C>T	c.(2044-2046)ggC>ggT	p.G682G		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	682	Fibronectin type-III 3.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GGTCTCCACGGCCCCCTGGCA	0.647000													23	77					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43376150	43376150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43376150C>T	ENST00000244296.2	-	3	615	c.478G>A	c.(478-480)Gag>Aag	p.E160K	PSG1_ENST00000403380.3_Intron|PSG1_ENST00000312439.6_Missense_Mutation_p.E160K|PSG1_ENST00000595356.1_Missense_Mutation_p.E160K|PSG1_ENST00000595124.1_Intron|PSG1_ENST00000436291.2_Missense_Mutation_p.E160K	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				TCCATGGTCTCCCTGGGATTT	0.537000													81	200					0	0	1	0	0
DAK	26007	broad.mit.edu	37	11	61106811	61106811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61106811C>T	ENST00000394900.3	+	5	619	c.390C>T	c.(388-390)atC>atT	p.I130I		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	130	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						CTGAAGGCATCCCGGTGGAGA	0.652000													14	113					0	0	1	0	0
GTF3C5	9328	broad.mit.edu	37	9	135919191	135919191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135919191C>T	ENST00000372097.5	+	3	773	c.450C>T	c.(448-450)ctC>ctT	p.L150L	GTF3C5_ENST00000372099.6_Silent_p.L141L|GTF3C5_ENST00000342018.8_Silent_p.L150L|GTF3C5_ENST00000372095.5_Silent_p.L25L|GTF3C5_ENST00000485692.1_3'UTR|GTF3C5_ENST00000372108.5_Silent_p.L150L	NM_012087.3	NP_036219.2	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5, 63kDa	150						transcription factor TFIIIC complex	DNA binding|protein binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		ACAAGGTGCTCATGCTCCGGC	0.582000													14	114					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53070861	53070861	+	Silent	SNP	G	G	A	rs137978741		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53070861G>A	ENST00000252244.3	-	6	1294	c.1236C>T	c.(1234-1236)atC>atT	p.I412I		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	412	Coil 2.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						TGACATTGTCGATTTCAGATC	0.453000													38	43					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111969148	111969148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111969148G>A	ENST00000369732.3	-	3	226	c.171C>T	c.(169-171)gcC>gcT	p.A57A	OVGP1_ENST00000540696.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	57					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TTGAGGCAAAGGCAAATATCA	0.483000													17	82					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20482391	20482391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20482391C>T	ENST00000504154.1	+	6	772	c.520C>T	c.(520-522)Ctc>Ttc	p.L174F	SLIT2_ENST00000273739.5_Missense_Mutation_p.L174F|SLIT2_ENST00000503823.1_Missense_Mutation_p.L174F|SLIT2_ENST00000503837.1_Missense_Mutation_p.L174F	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	174					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ATTCAGGGCTCTCCGGGACCT	0.448000													27	111					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38051357	38051357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38051357C>T	ENST00000357436.4	+	18	2085	c.1772C>T	c.(1771-1773)cCc>cTc	p.P591L	Z83844.1_ENST00000456099.1_RNA|SH3BP1_ENST00000599616.1_Intron	NM_018957.3	NP_061830.3	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	591					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					CCAGCCCCGCCCTTGCCCCCT	0.741000													6	8					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71153328	71153328	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71153328C>T	ENST00000355527.3	-	5	669	c.393G>A	c.(391-393)gaG>gaA	p.E131E	DHCR7_ENST00000407721.2_Silent_p.E131E	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	131					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	TCACGGCCCCCTCCTGGATGC	0.602000									Smith-Lemli-Opitz syndrome				5	11					0	0	1	0	0
AK5	26289	broad.mit.edu	37	1	77984380	77984380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:77984380G>A	ENST00000344720.5	+	11	2227	c.1201G>A	c.(1201-1203)Gac>Aac	p.D401N	AK5_ENST00000354567.2_Missense_Mutation_p.D427N	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	427					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						ATTGATCAGAGACATTATGGA	0.468000													13	48					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30936219	30936219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30936219C>T	ENST00000355537.3	+	2	1897	c.1750C>T	c.(1750-1752)Cac>Tac	p.H584Y		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGATTTGGTTCACAGCACTAA	0.517000													23	77					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72346877	72346877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:72346877C>T	ENST00000299687.5	+	1	3902	c.3902C>T	c.(3901-3903)cCc>cTc	p.P1301L	ZNF407_ENST00000582337.1_Missense_Mutation_p.P1301L|ZNF407_ENST00000577538.1_Missense_Mutation_p.P1301L|ZNF407_ENST00000309902.6_Missense_Mutation_p.P1301L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CAAGAAGATCCCGTTCTGGGG	0.448000													6	32					0	0	1	0	0
SPATA19	219938	broad.mit.edu	37	11	133714141	133714141	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:133714141C>T	ENST00000299140.3	-	4	413	c.359_splice	c.e4+1	p.S120_splice	SPATA19_ENST00000532889.1_Splice_Site_p.S120_splice	NM_174927.1	NP_777587.1	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19	120					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane				cervix(1)|endometrium(2)|large_intestine(2)|lung(5)|prostate(1)	11	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GACACCTTACCTCCATCTTAT	0.527000													29	87					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74592677	74592677	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74592677C>T	ENST00000361874.3	-	25	3311	c.2994G>A	c.(2992-2994)ctG>ctA	p.L998L	DCTN1_ENST00000394003.3_Silent_p.L991L|DCTN1_ENST00000409567.3_Silent_p.L978L|DCTN1_ENST00000407639.2_Silent_p.L864L|DCTN1_ENST00000409438.1_Silent_p.L864L|DCTN1_ENST00000409868.1_Silent_p.L981L|DCTN1_ENST00000409240.1_Silent_p.L961L	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	998					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						GGGTCTCCTCCAGCCGAGTCT	0.577000													12	43					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3844784	3844784	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3844784G>A	ENST00000309890.7	-	13	1860	c.1710C>T	c.(1708-1710)ccC>ccT	p.P570P	ATP2A3_ENST00000359983.3_Silent_p.P570P|ATP2A3_ENST00000352011.3_Silent_p.P570P|ATP2A3_ENST00000397041.3_Silent_p.P570P|ATP2A3_ENST00000397035.3_Silent_p.P570P|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397043.3_Silent_p.P570P	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	570					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCTTCCTTGGGGGCGCGTCCC	0.647000													28	77					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102477166	102477166	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102477166C>T	ENST00000360184.4	+	32	6659	c.6495C>T	c.(6493-6495)ttC>ttT	p.F2165F		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2165					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CGGACGTGTTCCCTGGAGTCC	0.532000													25	107					0	0	1	0	0
GHRHR	2692	broad.mit.edu	37	7	31008470	31008470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31008470G>A	ENST00000326139.2	+	2	125	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K		NM_000823.3	NP_000814.2	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	27					activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			biliary_tract(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35					Sermorelin(DB00010)	CATGCACCCAGAATGTGACTT	0.547000													12	48					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128454708	128454708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128454708C>T	ENST00000297788.4	+	15	3147	c.2780C>T	c.(2779-2781)aCc>aTc	p.T927I	CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000471729.1_3'UTR|CCDC136_ENST00000487361.1_Intron|CCDC136_ENST00000464832.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	927						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GAACTGCAGACCAAGCTGCGG	0.587000													12	32					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218940147	218940147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:218940147G>A	ENST00000374155.3	+	8	1402	c.992G>A	c.(991-993)gGg>gAg	p.G331E	RUFY4_ENST00000344321.7_Missense_Mutation_p.G311E|RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000463872.1_3'UTR			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	311							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GAGGTGATAGGGATGGAGGCT	0.572000													6	19					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13386683	13386683	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13386683G>A	ENST00000360228.5	-	24	3969	c.3970C>T	c.(3970-3972)Ctg>Ttg	p.L1324L	CACNA1A_ENST00000573710.2_Silent_p.L1325L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1325					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AAGGCTACCAGGGCCCCACTG	0.562000													12	28					0	0	1	0	0
OR51I2	390064	broad.mit.edu	37	11	5475583	5475583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5475583C>T	ENST00000341449.2	+	1	946	c.865C>T	c.(865-867)Cct>Tct	p.P289S	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTGCTCAACCCTCTCATTTA	0.463000													48	148					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52603813	52603813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52603813C>T	ENST00000395489.2	-	6	544	c.148G>A	c.(148-150)Gaa>Aaa	p.E50K	A1CF_ENST00000373993.1_Missense_Mutation_p.E57K|A1CF_ENST00000282641.2_Missense_Mutation_p.E57K|A1CF_ENST00000373997.3_Missense_Mutation_p.E57K|A1CF_ENST00000374001.1_Missense_Mutation_p.E57K|A1CF_ENST00000395495.1_Missense_Mutation_p.E57K|A1CF_ENST00000373995.3_Missense_Mutation_p.E65K	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	57					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ATAAAAATTTCACAGCCCCTT	0.428000													30	115					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48370644	48370644	+	Missense_Mutation	SNP	G	G	A	rs138519620	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48370644G>A	ENST00000395702.2	+	2	339	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	ZNF488_ENST00000586537.1_5'UTR|ZNF488_ENST00000494156.1_Missense_Mutation_p.E38K			Q96MN9	ZN488_HUMAN	zinc finger protein 488	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						GCGACTTAGCGAACCTGAGCT	0.667000													38	92					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147504348	147504348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147504348G>A	ENST00000359874.3	+	28	2760	c.2687G>A	c.(2686-2688)aGa>aAa	p.R896K	SPINK5_ENST00000398454.1_Missense_Mutation_p.R896K|SPINK5_ENST00000256084.7_Missense_Mutation_p.R896K	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	896	Kazal-like 13.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity	p.K899fs*3(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTAATGAAAGAAAAAAGAAA	0.303000													12	27					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77389943	77389943	+	Missense_Mutation	SNP	G	G	A	rs149929752		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77389943G>A	ENST00000282849.5	-	9	1772	c.1354C>T	c.(1354-1356)Ccc>Tcc	p.P452S		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	452	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.P452S(2)		NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTTCTGCAGGGATTCCCTTCT	0.428000													41	65					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182412572	182412572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182412572C>T	ENST00000410087.3	-	9	1236	c.1136G>A	c.(1135-1137)aGg>aAg	p.R379K	CERKL_ENST00000374969.2_Missense_Mutation_p.R266K|CERKL_ENST00000339098.5_Missense_Mutation_p.R405K|CERKL_ENST00000409440.3_Missense_Mutation_p.R361K|CERKL_ENST00000374970.2_Missense_Mutation_p.R310K|CERKL_ENST00000479558.1_5'UTR	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	405					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity	p.R405M(1)|p.R379M(1)		NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TCCCTGTGCCCTCCTAAAAGA	0.393000													62	129					0	0	1	0	0
LRP12	29967	broad.mit.edu	37	8	105509965	105509965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:105509965G>A	ENST00000276654.5	-	5	923	c.815C>T	c.(814-816)tCt>tTt	p.S272F	LRP12_ENST00000424843.2_Missense_Mutation_p.S253F	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	272	CUB 2.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding	p.S272F(1)		NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATAATTGGGAGAATTAAAAGT	0.398000													26	53					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880393	74880393	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74880393C>T	ENST00000289575.5	+	5	1019	c.624C>T	c.(622-624)ccC>ccT	p.P208P	SLCO2B1_ENST00000428359.2_Silent_p.P186P|SLCO2B1_ENST00000454962.2_Intron|SLCO2B1_ENST00000341411.4_Intron|SLCO2B1_ENST00000526660.1_Intron|SLCO2B1_ENST00000531756.1_Intron|SLCO2B1_ENST00000532236.1_Silent_p.P92P|SLCO2B1_ENST00000525650.1_Silent_p.P64P	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	208					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	CCATTCAGCCCTTTGGCATCT	0.597000													21	78					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833228	24833228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24833228G>A	ENST00000376451.2	+	14	4338	c.4078G>A	c.(4078-4080)Gaa>Aaa	p.E1360K	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000376454.3_Missense_Mutation_p.E1677K			Q5T5P2	SKT_HUMAN	KIAA1217	1677					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						TAAACAGCTCGAAAATACAAT	0.433000													24	60					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177247899	177247899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177247899C>T	ENST00000361539.4	+	7	1525	c.1213C>T	c.(1213-1215)Cgc>Tgc	p.R405C	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		405						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						TCGCCAGCCTCGCTTCCGCCT	0.617000													21	65					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	711134	711134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:711134C>T	ENST00000382303.1	+	7	1020	c.368C>T	c.(367-369)cCc>cTc	p.P123L	KANK1_ENST00000382293.3_5'UTR|KANK1_ENST00000382297.2_Missense_Mutation_p.P123L|KANK1_ENST00000489369.1_3'UTR	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	123					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		AAGCCACCTCCCCCTCTGGAG	0.502000													54	57					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54687453	54687453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54687453G>A	ENST00000245615.1	-	5	924	c.444C>T	c.(442-444)tcC>tcT	p.S148S	MBOAT7_ENST00000431666.2_Silent_p.S75S|MBOAT7_ENST00000338624.6_Silent_p.S75S|MBOAT7_ENST00000474910.1_5'UTR|MBOAT7_ENST00000391754.1_Silent_p.S148S	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	148					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCTCCATCAGGGAGGGCACGT	0.612000													7	78					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20636224	20636224	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20636224G>A	ENST00000525748.1	+	6	1258		c.e6-1			NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5						synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CTCCTAAACAGATTCCTGTGT	0.393000													38	105					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42880627	42880627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42880627C>T	ENST00000334370.4	+	41	8672	c.8037C>T	c.(8035-8037)ccC>ccT	p.P2679P	MEGF8_ENST00000251268.6_Silent_p.P2746P|MEGF8_ENST00000378073.4_Silent_p.P340P	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2746						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CCTGGGGACCCATGGGAGGGG	0.726000													6	4					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89671687	89671687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89671687C>T	ENST00000264344.5	-	15	2035	c.1828G>A	c.(1828-1830)Gaa>Aaa	p.E610K	FAM13A_ENST00000503556.1_Missense_Mutation_p.E270K|FAM13A_ENST00000513837.1_Missense_Mutation_p.E256K|FAM13A_ENST00000511976.1_Missense_Mutation_p.E196K|FAM13A_ENST00000508369.1_Missense_Mutation_p.E284K|FAM13A_ENST00000395002.2_Missense_Mutation_p.E284K	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	610					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TCGCTGTCTTCGTCCAGCAGC	0.602000													30	97					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123345767	123345767	+	Silent	SNP	C	C	T	rs141649592	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123345767C>T	ENST00000360772.3	-	31	5361	c.4983G>A	c.(4981-4983)caG>caA	p.Q1661Q	MYLK_ENST00000346322.5_Silent_p.Q1643Q|MYLK_ENST00000359169.1_Silent_p.Q1661Q|MYLK_ENST00000475616.1_Silent_p.Q1712Q|MYLK-AS1_ENST00000470449.1_RNA|MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000354792.5_Silent_p.Q512Q|MYLK-AS1_ENST00000463408.1_RNA|MYLK_ENST00000360304.3_Silent_p.Q1712Q			Q15746	MYLK_HUMAN	myosin light chain kinase	1712	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCTGAAGGCACTGCGTGCAGT	0.507000													11	63					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10893725	10893725	+	Missense_Mutation	SNP	C	C	T	rs145607989	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10893725C>T	ENST00000314646.5	+	6	942	c.778C>T	c.(778-780)Ctc>Ttc	p.L260F	DNM2_ENST00000389253.4_Missense_Mutation_p.L260F|DNM2_ENST00000585892.1_Missense_Mutation_p.L260F|DNM2_ENST00000408974.4_Missense_Mutation_p.L260F|DNM2_ENST00000359692.6_Missense_Mutation_p.L260F|DNM2_ENST00000355667.6_Missense_Mutation_p.L260F			P50570	DYN2_HUMAN	dynamin 2	260					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GAAGTTCTTCCTCTCCCACCC	0.587000			"""F, N, Splice, Mis, O"""		ETP ALL								22	53					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42289183	42289183	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42289183C>T	ENST00000361204.4	+	12	2437	c.2271C>T	c.(2269-2271)tcC>tcT	p.S757S	SREBF2_ENST00000491541.1_3'UTR	NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	757					cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TTCCTGACTCCCTGCGCTGGC	0.602000													27	100					0	0	1	0	0
MMRN2	79812	broad.mit.edu	37	10	88702482	88702482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88702482C>T	ENST00000372027.4	-	6	2132	c.2059G>A	c.(2059-2061)Gag>Aag	p.E687K		NM_024756.2	NP_079032.2	Q9H8L6	MMRN2_HUMAN	multimerin 2	687						extracellular space				breast(1)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|stomach(1)	19						GCGGCCTCCTCGCGGCCCGCG	0.771000													4	2					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207669671	207669671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207669671C>T	ENST00000367049.4	+	1	59	c.59C>T	c.(58-60)cCc>cTc	p.P20L	CR1_ENST00000367052.1_Missense_Mutation_p.P20L|CR1_ENST00000367050.4_3'UTR|CR1_ENST00000367051.1_Missense_Mutation_p.P20L|CR1_ENST00000400960.2_Missense_Mutation_p.P20L|CR1_ENST00000367053.1_Missense_Mutation_p.P20L	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	20					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCCGGTCTCCCCTTCTGCTGC	0.682000													17	28					0	0	1	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35928300	35928300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35928300G>A	ENST00000325722.3	-	8	1450	c.1216C>T	c.(1216-1218)Cgg>Tgg	p.R406W	KIAA0319L_ENST00000485551.1_5'UTR	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	406						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATGGGGGGCCGATTCTTACGG	0.448000													23	64					0	0	1	0	0
ADCK1	57143	broad.mit.edu	37	14	78353570	78353570	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:78353570C>T	ENST00000238561.5	+	5	659	c.560C>T	c.(559-561)tCg>tTg	p.S187L	ADCK1_ENST00000341211.5_Missense_Mutation_p.S119L	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	194	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GCTCAGAGCTCGAAGGACATT	0.617000													25	75					0	0	1	0	0
PSG11	5680	broad.mit.edu	37	19	43519322	43519322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43519322G>A	ENST00000401740.1	-	4	1013	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C	PSG11_ENST00000403486.1_Missense_Mutation_p.R182C|PSG11_ENST00000320078.7_Missense_Mutation_p.R304C|PSG11_ENST00000306322.7_Missense_Mutation_p.R182C			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	304	Ig-like C2-type 2.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				GCTGAGTTACGAGCAGAGCAA	0.458000													119	120					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69536328	69536328	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69536328C>T	ENST00000338206.5	-	1	18	c.9G>A	c.(7-9)ctG>ctA	p.L3L		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	3					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										ACGTCCATTTCAGAGACATCC	0.398000													88	342					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7807996	7807996	+	Missense_Mutation	SNP	C	C	T	rs11465393	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7807996C>T	ENST00000315599.7	-	7	1166	c.1144G>A	c.(1144-1146)Gcc>Acc	p.A382T	CD209_ENST00000593660.1_Missense_Mutation_p.A312T|CD209_ENST00000602261.1_Missense_Mutation_p.A290T|CD209_ENST00000601951.1_Missense_Mutation_p.A358T|CD209_ENST00000394161.5_Missense_Mutation_p.A146T|CD209_ENST00000593821.1_Missense_Mutation_p.A246T|CD209_ENST00000204801.8_Missense_Mutation_p.A338T|CD209_ENST00000315591.8_Missense_Mutation_p.A358T|CD209_ENST00000394173.4_Missense_Mutation_p.A221T|CD209_ENST00000301357.8_Missense_Mutation_p.A246T|CD209_ENST00000354397.6_Missense_Mutation_p.A376T	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	382			A -> S (in dbSNP:rs11465393).		cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.A382T(2)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GAGCAGGAGGCTGCGGACTTT	0.522000													74	165					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141526869	141526869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141526869C>T	ENST00000389484.3	-	35	6642	c.5671G>A	c.(5671-5673)Gga>Aga	p.G1891R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1891					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGAGGTATTCCCCTGATTCCT	0.408000										TSP Lung(27;0.18)			16	84					0	0	1	0	0
GHDC	84514	broad.mit.edu	37	17	40344692	40344692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40344692G>A	ENST00000301671.8	-	4	897	c.456C>T	c.(454-456)gcC>gcT	p.A152A	GHDC_ENST00000436923.2_Silent_p.A152A|GHDC_ENST00000414034.3_Silent_p.A152A|GHDC_ENST00000428494.2_Silent_p.A113A|GHDC_ENST00000587427.1_Silent_p.A152A|GHDC_ENST00000593209.1_Silent_p.A152A			Q8N2G8	GHDC_HUMAN	GH3 domain containing	152						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GCGTCACACGGGCAGTGCGTC	0.637000													20	36					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891892	2891892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:2891892G>A	ENST00000254528.3	+	4	1926	c.1767G>A	c.(1765-1767)acG>acA	p.T589T		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	589					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		TCAACGACACGATGCACAGGA	0.448000													23	34					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108682331	108682331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108682331C>T	ENST00000232603.5	-	27	2811	c.2729G>A	c.(2728-2730)aGa>aAa	p.R910K	MORC1_ENST00000483760.1_Missense_Mutation_p.R889K	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	910					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AGAGATTTTTCTTTTATTTTC	0.328000													34	144					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17415876	17415876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17415876C>T	ENST00000470360.1	+	10	1502	c.1385C>T	c.(1384-1386)tCt>tTt	p.S462F	SLC7A2_ENST00000494857.1_Missense_Mutation_p.S423F|SLC7A2_ENST00000522656.1_Missense_Mutation_p.S423F|SLC7A2_ENST00000398090.3_Missense_Mutation_p.S462F|SLC7A2_ENST00000004531.10_Missense_Mutation_p.S463F			P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	423					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	ATGGCCTACTCTCTGGTGGCA	0.532000													6	69					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600263	92600263	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92600263C>T	ENST00000298047.6	+	21	12032	c.12015C>T	c.(12013-12015)ttC>ttT	p.F4005F	FAT3_ENST00000533797.1_Silent_p.F340F|FAT3_ENST00000409404.2_Silent_p.F4005F|FAT3_ENST00000525166.1_Silent_p.F3855F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4005	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCAGCAGCTTCGCGGAGGTGG	0.662000										TCGA Ovarian(4;0.039)			3	6					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106717498	106717498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:106717498G>A	ENST00000428048.2	-	6	574	c.517C>T	c.(517-519)Cct>Tct	p.P173S	UXS1_ENST00000283148.7_Intron|UXS1_ENST00000409032.1_Intron|UXS1_ENST00000540130.1_Intron|UXS1_ENST00000409501.3_Intron			Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	0					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						CAGAGTGGAGGGAGAGGAGCA	0.532000													26	67					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62417456	62417456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62417456G>A	ENST00000528405.1	-	4	286	c.278C>T	c.(277-279)cCc>cTc	p.P93L	INTS5_ENST00000330574.2_Silent_p.S32S																							TGATTTCCTGGGACAGCTCCT	0.493000													15	55					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172001634	172001634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:172001634C>T	ENST00000358155.4	+	5	858	c.682C>T	c.(682-684)Cgc>Tgc	p.R228C	DNM3_ENST00000367733.2_Missense_Mutation_p.R228C|DNM3_ENST00000520906.1_Missense_Mutation_p.R228C|DNM3_ENST00000367731.1_Missense_Mutation_p.R228C|DNM3_ENST00000355305.5_Missense_Mutation_p.R228C	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	228					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GTTGCCTCTTCGCAGGGGTAA	0.393000													26	73					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46727042	46727042	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46727042G>A	ENST00000318962.4	-	7	842	c.759C>T	c.(757-759)ctC>ctT	p.L253L	ALS2CL_ENST00000415953.1_Silent_p.L253L	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	253					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CATCATCAAAGAGCAGCACAC	0.617000													9	30					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385766	33385766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33385766G>A	ENST00000541274.1	-	5	678	c.229C>T	c.(229-231)Cct>Tct	p.P77S	AQP7_ENST00000377425.4_Silent_p.I151I|AQP7_ENST00000539936.1_Silent_p.I208I|AQP7_ENST00000537089.1_Silent_p.I116I			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		TGACCACGAGGATGCCTATCA	0.602000													30	79					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133883997	133883997	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:133883997A>T	ENST00000285928.2	+	14	1640	c.1571A>T	c.(1570-1572)tAt>tTt	p.Y524F		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	524	Guanylate kinase-like.						ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						AAATATTCCTATTTTGAGCCT	0.353000													17	127					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74975996	74975996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74975996G>A	ENST00000261978.4	-	22	3734	c.3348C>T	c.(3346-3348)tcC>tcT	p.S1116S	LTBP2_ENST00000556690.1_Silent_p.S1116S	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1116	Cys-rich.|EGF-like 10; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGTCCTTGCAGGAGAAGGAGC	0.642000													31	100					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55481539	55481539	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55481539G>A	ENST00000543010.1	+	2	299	c.156G>A	c.(154-156)ggG>ggA	p.G52G	NLRP2_ENST00000263437.6_Silent_p.G52G|NLRP2_ENST00000537859.1_Silent_p.G52G|NLRP2_ENST00000391721.4_Silent_p.G52G|NLRP2_ENST00000448584.2_Silent_p.G52G|NLRP2_ENST00000339757.7_Silent_p.G52G|NLRP2_ENST00000538819.1_Silent_p.G52G|NLRP2_ENST00000427260.2_Intron	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	52	DAPIN.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AGGCTGATGGGAAGCAACTGG	0.527000													16	63					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174906	51174906	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51174906G>A	ENST00000440970.1	-	2	1367	c.936C>T	c.(934-936)atC>atT	p.I312I	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.I409I|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	409					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CAGTTGTTCCGATGTTGGGCA	0.478000													37	106					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38537884	38537884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38537884C>T	ENST00000399017.2	+	33	6115	c.3368C>T	c.(3367-3369)cCc>cTc	p.P1123L	TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Missense_Mutation_p.P1123L|TTC3_ENST00000355666.1_Missense_Mutation_p.P1123L	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1123					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				GAACATGGTCCCTTGGACATG	0.338000													79	170					0	0	1	0	0
SLC20A2	6575	broad.mit.edu	37	8	42302216	42302216	+	Silent	SNP	G	G	A	rs116687117	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42302216G>A	ENST00000342228.3	-	6	1047	c.678C>T	c.(676-678)ttC>ttT	p.F226F	SLC20A2_ENST00000520262.1_Silent_p.F226F|SLC20A2_ENST00000520179.1_Silent_p.F226F	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	226					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CAAAAAAAGCGAACAGGAGGG	0.493000													31	55					0	0	1	0	0
SUCNR1	56670	broad.mit.edu	37	3	151597688	151597688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151597688G>A	ENST00000362032.4	+	2	113	c.8G>A	c.(7-9)gGg>gAg	p.G3E	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_033050.4	NP_149039.2	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	3						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	GACATGCTGGGGATCATGGTA	0.343000													16	67					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092435	151092435	+	Missense_Mutation	SNP	C	C	T	rs140138379		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151092435C>T	ENST00000370335.1	+	3	566	c.299C>T	c.(298-300)cCt>cTt	p.P100L	MAGEA4_ENST00000276344.2_Missense_Mutation_p.P100L|MAGEA4_ENST00000393921.1_Missense_Mutation_p.P100L|MAGEA4_ENST00000370340.3_Missense_Mutation_p.P100L|MAGEA4_ENST00000370337.4_Missense_Mutation_p.P100L|MAGEA4_ENST00000360243.2_Missense_Mutation_p.P100L|MAGEA4_ENST00000393920.1_Missense_Mutation_p.P100L			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	100							protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AGCACCTCGCCTGACGCAGAG	0.557000													29	49					0	0	1	0	0
MPV17L2	84769	broad.mit.edu	37	19	18304780	18304780	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18304780C>T	ENST00000599612.2	+	2	394	c.294C>T	c.(292-294)gtC>gtT	p.V98V	MPV17L2_ENST00000534474.2_Silent_p.V98V	NM_032683.2	NP_116072.2	Q567V2	M17L2_HUMAN	MPV17 mitochondrial membrane protein-like 2	98						integral to membrane				large_intestine(1)|lung(2)|urinary_tract(1)	4						TCCCAAATGTCCTCAAGAAGG	0.577000													21	30					0	0	1	0	0
C12orf68	387856	broad.mit.edu	37	12	48578415	48578415	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48578415G>A	ENST00000316554.3	+	1	1050	c.510G>A	c.(508-510)ggG>ggA	p.G170G		NM_001013635.3	NP_001013657.3	Q52MB2	CL068_HUMAN	chromosome 12 open reading frame 68	170						cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)	4						TCCTTGGGGGGGACGGGCCAC	0.652000													4	7					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62718868	62718868	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62718868C>T	ENST00000371153.4	-	8	2931	c.2553G>A	c.(2551-2553)gtG>gtA	p.V851V	KANK4_ENST00000371150.1_Silent_p.V207V|KANK4_ENST00000317477.4_5'UTR|KANK4_ENST00000354381.3_Silent_p.V223V	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	851										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						TCTGATGGTCCACATTGCAGA	0.537000													27	87					0	0	1	0	0
SIX3	6496	broad.mit.edu	37	2	45169955	45169955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:45169955G>A	ENST00000260653.3	+	1	1054	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_005413.3	NP_005404.1	O95343	SIX3_HUMAN	SIX homeobox 3	238					visual perception	nucleus				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|skin(1)	11		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAAGAAACGCGAACTGGCGCA	0.637000													14	69					0	0	1	0	0
SETD7	80854	broad.mit.edu	37	4	140439176	140439176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:140439176G>A	ENST00000274031.3	-	7	1419	c.783C>T	c.(781-783)gcC>gcT	p.A261A	SETD7_ENST00000506866.2_Silent_p.A261A	NM_030648.2	NP_085151.1	Q8WTS6	SETD7_HUMAN	SET domain containing (lysine methyltransferase) 7	261	SET.				peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	8	all_hematologic(180;0.156)					TCCCATTAAGGGCCCAGTCCC	0.488000													8	33					0	0	1	0	0
SYVN1	84447	broad.mit.edu	37	11	64899785	64899785	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64899785G>A	ENST00000526060.1	-	6	657	c.465C>T	c.(463-465)ttC>ttT	p.F155F	SYVN1_ENST00000377190.3_Silent_p.F155F|SYVN1_ENST00000526121.1_5'UTR|SYVN1_ENST00000307289.6_Intron|SYVN1_ENST00000294256.8_Silent_p.F155F			Q86TM6	SYVN1_HUMAN	synovial apoptosis inhibitor 1, synoviolin	155					ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding	p.F155F(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						CGTGGCTGACGAAGAGGAAGT	0.592000													30	70					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141310388	141310388	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141310388C>T	ENST00000325617.5	-	15	2263	c.1823G>A	c.(1822-1824)cGa>cAa	p.R608Q	CLGN_ENST00000414773.1_Missense_Mutation_p.R608Q|CLGN_ENST00000537281.1_Missense_Mutation_p.R608Q	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	608					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					TTAGTCCTTTCGTACTCTTCT	0.373000													30	68					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54186144	54186144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54186144C>T	ENST00000259782.4	+	3	565	c.469C>T	c.(469-471)Cgt>Tgt	p.R157C	TINAG_ENST00000370864.3_Missense_Mutation_p.R139C|TINAG_ENST00000370869.3_Missense_Mutation_p.R153C|TINAG_ENST00000486436.1_3'UTR	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	157					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			ATGCCTTGTTCGTTCAGAATT	0.378000													13	39					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179544834	179544834	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179544834C>T	ENST00000367615.4	-	1	234	c.166G>A	c.(166-168)Gag>Aag	p.E56K	NPHS2_ENST00000367616.4_Missense_Mutation_p.E56K	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	56					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GCTCGGGGCTCCCCCGGGGTC	0.771000													8	8					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204425	56204425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56204425G>A	ENST00000361673.3	-	5	3207	c.2994C>T	c.(2992-2994)tgC>tgT	p.C998C	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	998							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TCGCTTGAAAGCACTCATTAT	0.488000													46	68					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76471470	76471470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76471470C>T	ENST00000389840.5	-	54	8483	c.8359G>A	c.(8359-8361)Ggg>Agg	p.G2787R	DNAH17_ENST00000585328.1_Missense_Mutation_p.G2796R|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCGCCCACCCCCACCAGCAGG	0.612000													25	81					0	0	1	0	0
BATF	10538	broad.mit.edu	37	14	76013005	76013005	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:76013005C>G	ENST00000286639.6	+	3	627	c.369C>G	c.(367-369)ttC>ttG	p.F123L	BATF_ENST00000555504.1_Intron|BATF_ENST00000555795.1_3'UTR	NM_006399.3	NP_006390.1	Q16520	BATF_HUMAN	basic leucine zipper transcription factor, ATF-like	123						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.028)		CCCCGCGCTTCCAGCCCTGAG	0.697000													6	14					0	0	1	0	0
CLPP	8192	broad.mit.edu	37	19	6364601	6364601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6364601C>T	ENST00000245816.4	+	4	629	c.506C>T	c.(505-507)tCg>tTg	p.S169L	CLPP_ENST00000596149.1_Missense_Mutation_p.S82L|CLPP_ENST00000596605.1_Intron	NM_006012.2	NP_006003.1	Q16740	CLPP_HUMAN	caseinolytic mitochondrial matrix peptidase proteolytic subunit	169					proteolysis	mitochondrial matrix	ATP binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|ovary(2)	6						ATGCGCCACTCGCTCCCCAAC	0.657000													23	36					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	362409	362409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:362409C>T	ENST00000342640.4	-	8	973	c.931G>A	c.(931-933)Gac>Aac	p.D311N	THEG_ENST00000346878.2_Missense_Mutation_p.D287N	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	311					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCACTTGTCCGACTGAGCT	0.592000													38	83					0	0	1	0	0
NRBP1	29959	broad.mit.edu	37	2	27656267	27656267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27656267C>T	ENST00000233557.3	+	3	959	c.127C>T	c.(127-129)Cca>Tca	p.P43S	NRBP1_ENST00000379863.3_Missense_Mutation_p.P43S|NRBP1_ENST00000379852.3_Missense_Mutation_p.P43S			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	43					ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					AGCTGCTTCCCCAGAGGAAGA	0.522000													13	80					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24309442	24309442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:24309442G>A	ENST00000357002.4	+	4	755	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	ZNF254_ENST00000342944.6_Missense_Mutation_p.E129K	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	214					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				CAAATGTAAAGAATGTGGAAA	0.303000													23	106					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72903596	72903596	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72903596G>A	ENST00000339594.4	-	6	1157	c.819C>T	c.(817-819)gtC>gtT	p.V273V	BAZ1B_ENST00000404251.1_Silent_p.V273V	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	273	Mediates the tyrosine-protein kinase activity.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding	p.V273V(1)		NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				CATCTTCTACGACCCAAGGTG	0.423000													24	105					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281220	152281220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152281220C>T	ENST00000368799.1	-	3	6177	c.6142G>A	c.(6142-6144)Gag>Aag	p.E2048K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2048	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAATGTCCCTCACTGTCACTG	0.562000									Ichthyosis				232	548					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47958661	47958661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47958661G>A	ENST00000426837.2	-	8	794	c.707C>T	c.(706-708)cCc>cTc	p.P236L	MAP4_ENST00000383737.4_Missense_Mutation_p.P219L|MAP4_ENST00000395734.3_Missense_Mutation_p.P219L|MAP4_ENST00000360240.6_Missense_Mutation_p.P219L			P27816	MAP4_HUMAN	microtubule-associated protein 4	219					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TAGCTCTAAGGGAACTAAATT	0.413000													37	109					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43411806	43411806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43411806C>T	ENST00000187910.2	-	4	972	c.907G>A	c.(907-909)Gaa>Aaa	p.E303K	PSG6_ENST00000292125.2_Missense_Mutation_p.E303K|PSG6_ENST00000402603.4_Intron	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				GGTCCTGTTTCATTTCTCGTG	0.493000													105	248					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107956543	107956543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:107956543C>T	ENST00000285311.3	-	1	911	c.206G>A	c.(205-207)gGc>gAc	p.G69D	DKK2_ENST00000513208.1_Intron|DKK2_ENST00000510463.1_Intron	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	69					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CAGGTTTTTGCCCTTCTTACT	0.577000													11	77					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11071021	11071021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11071021C>T	ENST00000287766.4	+	12	1727	c.1306C>T	c.(1306-1308)Ctc>Ttc	p.L436F	SLC6A1_ENST00000536032.1_Missense_Mutation_p.L258F	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	436					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCTGATCGGTCTCTCTAACAT	0.592000													9	43					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070509	9070509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9070509G>A	ENST00000397910.4	-	3	17140	c.16937C>T	c.(16936-16938)tCc>tTc	p.S5646F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5648	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATGTGGAGGAAACAGGAGA	0.517000													12	21					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118456684	118456684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:118456684C>T	ENST00000311085.8	+	9	1032	c.952C>T	c.(952-954)Cgt>Tgt	p.R318C	DMXL1_ENST00000539542.1_Missense_Mutation_p.R318C	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	318										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GAGACATTTTCGTAGAGGTCG	0.398000													12	141					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193080175	193080175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:193080175C>T	ENST00000342358.4	-	5	648	c.531G>A	c.(529-531)gaG>gaA	p.E177E		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	177					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CCTACCTGACCTCTTGCTCTT	0.418000													19	43					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142480031	142480031	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142480031G>A	ENST00000603901.1	+	0	163					NR_001296.3																						CCTCATCAGCGAACAGTGGGT	0.577000													48	140					0	0	1	0	0
HTRA3	94031	broad.mit.edu	37	4	8305930	8305930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8305930G>A	ENST00000307358.2	+	8	1324	c.1120G>A	c.(1120-1122)Gcc>Acc	p.A374T		NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	374	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						TGAGCTGAAGGCCAGCAACCC	0.587000													12	35					0	0	1	0	0
SDR16C5	195814	broad.mit.edu	37	8	57221519	57221519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57221519G>A	ENST00000396721.2	-	3	531	c.401C>T	c.(400-402)tCa>tTa	p.S134L	SDR16C5_ENST00000522671.1_Missense_Mutation_p.S178L|SDR16C5_ENST00000303749.3_Missense_Mutation_p.S178L			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	178					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						TAATCCAGCTGAACTTGAAAT	0.333000													28	51					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230928654	230928654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230928654G>A	ENST00000354537.1	+	16	1854	c.1772G>A	c.(1771-1773)cGg>cAg	p.R591Q	CAPN9_ENST00000480004.1_3'UTR|CAPN9_ENST00000366666.2_Missense_Mutation_p.R554Q|CAPN9_ENST00000271971.2_Missense_Mutation_p.R617Q|RP11-99J16__A.2_ENST00000452640.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA|RP11-99J16__A.2_ENST00000428480.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	617	Domain IV.|EF-hand 2.|EF-hand 3.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TATGAACTACGGACTGCACTG	0.527000													65	119					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554173	135554173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135554173C>T	ENST00000372146.4	+	2	1731	c.1167C>T	c.(1165-1167)agC>agT	p.S389S	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	389					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GTAGTTGCAGCTTAGTAGTGG	0.443000													56	123					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77951244	77951244	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77951244G>A	ENST00000342219.4	-	2	216	c.160C>T	c.(160-162)Cct>Tct	p.P54S	ISM2_ENST00000429906.1_Intron|ISM2_ENST00000393684.3_5'UTR|ISM2_ENST00000412904.1_Missense_Mutation_p.P54S|ISM2_ENST00000493585.1_Missense_Mutation_p.P54S	NM_199296.2	NP_954993.1	Q6H9L7	ISM2_HUMAN	isthmin 2	54						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						AGAGGCCTAGGATCTGGGGAG	0.607000													7	73					0	0	1	0	0
UBE3A	7337	broad.mit.edu	37	15	25585356	25585356	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25585356G>A	ENST00000232165.3	-	12	3030	c.2374C>T	c.(2374-2376)Cat>Tat	p.H792Y	UBE3A_ENST00000566215.1_Missense_Mutation_p.H772Y|UBE3A_ENST00000438097.1_Missense_Mutation_p.H772Y|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000428984.2_Missense_Mutation_p.H772Y|UBE3A_ENST00000397954.2_Missense_Mutation_p.H795Y	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	795	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GTAAATGAATGAACGATTTCC	0.368000													30	86					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	39980049	39980049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:39980049G>A	ENST00000308666.3	-	7	1832	c.1697C>T	c.(1696-1698)tCa>tTa	p.S566L		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	566	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						ATCATCCACTGAATCAGGGTA	0.388000													30	46					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68905294	68905294	+	Silent	SNP	G	G	A	rs114379164	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:68905294G>A	ENST00000262340.5	-	7	728	c.675C>T	c.(673-675)atC>atT	p.I225I		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	225					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						ATTGTACAACGATCTCTGACT	0.363000													27	102					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131859669	131859669	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131859669C>T	ENST00000286355.5	-	11	4595		c.e11+1		ADCY8_ENST00000377928.3_Intron	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TAAATAAATACCTCTGGGTAG	0.423000										HNSCC(32;0.087)			13	21					0	0	1	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78316640	78316640	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78316640A>C	ENST00000409931.3	-	6	1399	c.1328T>G	c.(1327-1329)cTc>cGc	p.L443R	TBC1D2B_ENST00000300584.3_Missense_Mutation_p.L443R			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	443						intracellular	protein binding|Rab GTPase activator activity			breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GGTCTCCATGAGCATTCCCAG	0.602000													27	78					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2820382	2820382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2820382C>T	ENST00000301740.8	+	13	8600	c.8051C>T	c.(8050-8052)tCc>tTc	p.S2684F		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2684	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						CCAATAGACTCCCTCAGGGAC	0.652000													3	13					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43771281	43771281	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43771281G>A	ENST00000389420.3	-	32	4881	c.4882C>T	c.(4882-4884)Cga>Tga	p.R1628*		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1628	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GGCCGAAGTCGATGGAGCTTA	0.408000													8	32					0	0	1	0	0
AVPR1A	552	broad.mit.edu	37	12	63541245	63541245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:63541245C>T	ENST00000299178.2	-	2	1256	c.1151G>A	c.(1150-1152)aGa>aAa	p.R384K		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	384					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	AAAAGTCTGTCTTCTGCTCAT	0.403000													23	117					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60904229	60904229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60904229G>A	ENST00000252999.3	-	33	4266	c.4200C>T	c.(4198-4200)ttC>ttT	p.F1400F		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1400	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTGGCTGATGAAGTCATAGG	0.632000													26	71					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13746268	13746268	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:13746268G>C	ENST00000383314.2	+	9	1429	c.1189G>C	c.(1189-1191)Gaa>Caa	p.E397Q	RNMT_ENST00000592764.1_Missense_Mutation_p.E397Q|RNMT_ENST00000589866.1_Missense_Mutation_p.E397Q|RNMT_ENST00000262173.3_Missense_Mutation_p.E397Q|RNMT_ENST00000543302.2_Missense_Mutation_p.E397Q|RNMT_ENST00000535051.1_Missense_Mutation_p.E155Q			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	397					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						AACATTTCTGGAATTCTACGA	0.308000													32	84					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37948651	37948651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37948651C>T	ENST00000377707.3	-	5	1892	c.1327G>A	c.(1327-1329)Gac>Aac	p.D443N	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	443	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		AGGGAGTAGTCATGCTTGCTG	0.627000													6	56					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74635414	74635414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74635414G>A	ENST00000358632.4	-	5	1115	c.420C>T	c.(418-420)taC>taT	p.Y140Y	CYP11A1_ENST00000541301.1_3'UTR|CYP11A1_ENST00000268053.6_Silent_p.Y298Y|CYP11A1_ENST00000419019.2_Silent_p.Y140Y	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	298					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GGATGCCACGGTAATCGTGGT	0.512000													81	82					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85530629	85530629	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85530629C>T	ENST00000295887.5	+	3	716	c.293C>T	c.(292-294)tCg>tTg	p.S98L		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	98					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		ACTATGATCTCGTTGTTTTTC	0.348000													49	103					0	0	1	0	0
SEC16A	9919	broad.mit.edu	37	9	139370186	139370186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139370186G>A	ENST00000313050.7	-	1	1955	c.1882C>T	c.(1882-1884)Cgc>Tgc	p.R628C	SEC16A_ENST00000290037.6_Missense_Mutation_p.R450C|SEC16A_ENST00000431893.2_Missense_Mutation_p.R450C|SEC16A_ENST00000371706.3_Missense_Mutation_p.R450C	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	450					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		ACGTTGGCGCGATCTGCCTCA	0.537000													3	9					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209200558	209200558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:209200558C>T	ENST00000264380.4	+	26	4456	c.4298C>T	c.(4297-4299)tCt>tTt	p.S1433F	PIKFYVE_ENST00000474721.1_3'UTR	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1433					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						AGACTTGCATCTTTGAAAACT	0.308000													7	86					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75108826	75108826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75108826C>T	ENST00000309664.5	+	3	528	c.389C>T	c.(388-390)tCg>tTg	p.S130L	LMAN1L_ENST00000379709.3_Missense_Mutation_p.S130L	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	130	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding	p.S130L(1)		NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGGCTGGCTTCGTGGGACGGC	0.667000													94	67					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278255	36278255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36278255C>T	ENST00000007510.4	+	21	2932	c.2788C>T	c.(2788-2790)Ccc>Tcc	p.P930S	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.P794S|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.P769S			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	930					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						TTCCCAATCCCCCTTCCACCG	0.701000													10	53					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241329	126241329	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126241329G>A	ENST00000394329.3	+	1	3776	c.3763G>A	c.(3763-3765)Gaa>Aaa	p.E1255K		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1255	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGGAAATGAAGAAAGACAGTT	0.373000													11	49					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49433990	49433990	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49433990G>A	ENST00000301067.7	-	31	7562	c.7563C>T	c.(7561-7563)tcC>tcT	p.S2521S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCGTCCCAGGGGACCGGACAA	0.672000													5	41					0	0	1	0	0
TNFRSF18	8784	broad.mit.edu	37	1	1139585	1139585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1139585G>A	ENST00000379268.2	-	4	549	c.430C>T	c.(430-432)Cct>Tct	p.P144S	TNFRSF18_ENST00000379265.5_Missense_Mutation_p.P144S|TNFRSF18_ENST00000486728.1_Missense_Mutation_p.P72S|TNFRSF18_ENST00000328596.6_Intron	NM_004195.2|NM_148902.1	NP_004186.1|NP_683700.1	Q9Y5U5	TNR18_HUMAN	tumor necrosis factor receptor superfamily, member 18	144					anti-apoptosis|apoptosis	extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTGTTCCCAGGGAACACAGTG	0.682000													3	15					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24210737	24210737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24210737C>T	ENST00000345044.6	+	3	458	c.190C>T	c.(190-192)Ctg>Ttg	p.L64L	SLC2A11_ENST00000316185.8_Silent_p.L67L|SLC2A11_ENST00000467660.1_3'UTR|SLC2A11_ENST00000403208.3_Silent_p.L64L|SLC2A11_ENST00000398356.2_Silent_p.L71L|SLC2A11_ENST00000405847.1_Silent_p.L64L|AP000350.10_ENST00000433835.3_Silent_p.L29L			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	64						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						TCACCTAGTCCTGCTTATGTG	0.562000													16	94					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172007471	172007471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:172007471C>T	ENST00000358155.4	+	7	1038	c.862C>T	c.(862-864)Cac>Tac	p.H288Y	DNM3_ENST00000367733.2_Missense_Mutation_p.H288Y|DNM3_ENST00000520906.1_Missense_Mutation_p.H288Y|DNM3_ENST00000367731.1_Missense_Mutation_p.H288Y|DNM3_ENST00000355305.5_Missense_Mutation_p.H288Y	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	288					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						ACTTACCAACCACATTCGGGA	0.378000													17	53					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8819105	8819105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:8819105C>T	ENST00000359865.3	+	13	3146	c.3004C>T	c.(3004-3006)Ccg>Tcg	p.P1002S	SOGA2_ENST00000517570.1_Missense_Mutation_p.P961S|SOGA2_ENST00000400050.3_Missense_Mutation_p.P961S|SOGA2_ENST00000306329.11_Missense_Mutation_p.P1321S|SOGA2_ENST00000306285.7_Missense_Mutation_p.P327S|SOGA2_ENST00000518815.1_Missense_Mutation_p.P327S	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1312																	TGACTCCATCCCGTTTGAAGA	0.597000													25	66					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141325255	141325255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141325255C>T	ENST00000231484.3	-	4	4456	c.3246G>A	c.(3244-3246)gaG>gaA	p.E1082E		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	1082					neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTTGGCTCCTCCGTGGCTG	0.632000													25	77					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57257945	57257945	+	Missense_Mutation	SNP	C	C	T	rs147103664		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57257945C>T	ENST00000343433.6	-	2	621	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	181								p.E181K(1)		NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TTCCTGGGTTCCTCTGGAGTA	0.488000													10	126					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160961164	160961164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160961164C>T	ENST00000447678.1	-	37	5766	c.5646G>A	c.(5644-5646)gtG>gtA	p.V1882V	LPA_ENST00000484276.1_5'UTR|LPA_ENST00000316300.5_Silent_p.V1882V	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4390	Kringle 17.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATTCGAGGTTCACTTCTTGGT	0.473000													39	43					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31342525	31342525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31342525C>T	ENST00000544665.3	+	29	3390	c.3319C>T	c.(3319-3321)Ctg>Ttg	p.L1107L	ITGAM_ENST00000287497.8_Silent_p.L1106L	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1106					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CCCCAACCCCCTGCCGCTCAT	0.677000													23	42					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4944978	4944978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4944978G>A	ENST00000321961.2	-	1	659	c.592C>T	c.(592-594)Cac>Tac	p.H198Y	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATAGATGTGATTGACAATG	0.532000													7	94					0	0	1	0	0
BRD7	29117	broad.mit.edu	37	16	50388763	50388763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50388763G>A	ENST00000394688.3	-	3	488	c.329C>T	c.(328-330)cCt>cTt	p.P110L	BRD7_ENST00000394689.2_Missense_Mutation_p.P110L|BRD7_ENST00000401491.3_5'UTR			Q9NPI1	BRD7_HUMAN	bromodomain containing 7	110					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				TAATCTCACAGGGGCGTGACA	0.443000													28	116					0	0	1	0	0
NOX1	27035	broad.mit.edu	37	X	100125744	100125744	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:100125744C>T	ENST00000372966.3	-	2	310	c.105G>A	c.(103-105)aaG>aaA	p.K35K	NOX1_ENST00000217885.5_Silent_p.K35K|NOX1_ENST00000372960.4_Silent_p.K35K|NOX1_ENST00000372964.1_Silent_p.K35K	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	35					angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						ATTTGTCGGCCTTCTCATATT	0.378000													38	42					0	0	1	0	0
GJB2	2706	broad.mit.edu	37	13	20763336	20763336	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:20763336C>T	ENST00000382844.1	-	1	583	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K	GJB2_ENST00000382848.4_Missense_Mutation_p.E129K			P29033	CXB2_HUMAN	gap junction protein, beta 2, 26kDa	129			E -> K (in DFNB1A).		cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane				breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		AGGGAGCCTTCGATGCGGACC	0.507000									Keratitis, Ichthyosis and Deafness syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	68					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177041212	177041212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:177041212G>A	ENST00000393643.2	+	4	754	c.502G>A	c.(502-504)Ggt>Agt	p.G168S	WDR17_ENST00000280190.4_Missense_Mutation_p.G192S|WDR17_ENST00000508596.1_Missense_Mutation_p.G168S|WDR17_ENST00000507824.2_Missense_Mutation_p.G192S	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	192										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		AGTTGTGTTTGGTCATATTGA	0.323000													29	153					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17578719	17578719	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17578719C>T	ENST00000319363.6	+	3	329	c.196C>T	c.(196-198)Cga>Tga	p.R66*	IL17RA_ENST00000477874.1_3'UTR	NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	66					fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity	p.R66*(1)		endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		GATTCACCCTCGAAACCTGAC	0.577000													21	48					0	0	1	0	0
ARHGAP4	393	broad.mit.edu	37	X	153174589	153174589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153174589G>A	ENST00000370028.3	-	22	2719	c.2662C>T	c.(2662-2664)Ccc>Tcc	p.P888S	ARHGAP4_ENST00000370016.1_Missense_Mutation_p.P827S|ARHGAP4_ENST00000350060.5_Missense_Mutation_p.P848S|ARHGAP4_ENST00000393721.1_Missense_Mutation_p.P670S|ARHGAP4_ENST00000537206.1_Missense_Mutation_p.P825S	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	848					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGTCCAGAGGGTCCCATGGCC	0.642000													19	9					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10713796	10713796	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10713796G>A	ENST00000377022.3	-	11	2635	c.2318C>T	c.(2317-2319)tCg>tTg	p.S773L	CASZ1_ENST00000344008.5_Missense_Mutation_p.S773L|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	773					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CAGCAGCCCCGAGATCTTGCT	0.701000													19	39					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86394822	86394822	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86394822G>A	ENST00000361669.2	+	2	1460	c.361G>A	c.(361-363)Gat>Aat	p.D121N	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Intron|GRM3_ENST00000394720.2_Missense_Mutation_p.D119N|GRM3_ENST00000439827.1_Missense_Mutation_p.D121N	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	121					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GACAAAAGTGGATGAAGCTGA	0.438000													46	146					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24671403	24671403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24671403G>A	ENST00000361548.4	+	12	1666	c.1436G>A	c.(1435-1437)gGa>gAa	p.G479E	GRHL3_ENST00000350501.5_Missense_Mutation_p.G479E|GRHL3_ENST00000356046.2_Missense_Mutation_p.G433E|GRHL3_ENST00000342072.4_Missense_Mutation_p.G386E|GRHL3_ENST00000236255.4_Missense_Mutation_p.G484E	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	479					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CCCTCGGCAGGACCCAGCAGC	0.597000													15	52					0	0	1	0	0
GGT7	2686	broad.mit.edu	37	20	33433180	33433180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33433180G>A	ENST00000336431.5	-	15	1984	c.1940C>T	c.(1939-1941)gCt>gTt	p.A647V	GGT7_ENST00000469018.1_5'UTR	NM_178026.2	NP_821158.2	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	647					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			NS(2)|breast(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)	20						GTCCTTAACAGCGATGATGAA	0.577000													21	43					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106509747	106509747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:106509747G>A	ENST00000359195.3	+	2	2051	c.1741G>A	c.(1741-1743)Gaa>Aaa	p.E581K	PIK3CG_ENST00000496166.1_Missense_Mutation_p.E581K|PIK3CG_ENST00000440650.2_Missense_Mutation_p.E581K	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	581					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						TTTTAGATACGAAAGCCTTAA	0.453000													39	71					0	0	1	0	0
OR51D1	390038	broad.mit.edu	37	11	4661107	4661107	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4661107C>T	ENST00000357605.2	+	1	163	c.87C>T	c.(85-87)atC>atT	p.I29I		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGTGGGTATCCCTGGCCTGG	0.507000													38	95					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54606840	54606840	+	Missense_Mutation	SNP	C	C	T	rs141787724		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54606840C>T	ENST00000371330.1	-	3	1541	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K		NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	232	CUB 2.					extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						ACCTGCAGTTCGTGGCCCAGA	0.637000													18	61					0	0	1	0	0
TNP2	7142	broad.mit.edu	37	16	11363045	11363045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11363045G>A	ENST00000312693.3	-	1	144	c.75C>T	c.(73-75)acC>acT	p.T25T	RMI2_ENST00000572173.1_Intron	NM_005425.4	NP_005416.1	Q05952	STP2_HUMAN	transition protein 2 (during histone to protamine replacement)	25					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding	p.0?(1)		large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6						GGCGGGTGCAGGTGCGGCTTT	0.632000													38	154					0	0	1	0	0
OR51I2	390064	broad.mit.edu	37	11	5474840	5474840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5474840G>A	ENST00000341449.2	+	1	203	c.122G>A	c.(121-123)gGa>gAa	p.G41E	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCCTTGGGGGAAATACAGTG	0.572000													28	52					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157805787	157805787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157805787C>T	ENST00000368174.4	-	3	310	c.214G>A	c.(214-216)Gga>Aga	p.G72R	CD5L_ENST00000484609.1_5'UTR	NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	72	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTAGGGGTTCCGCTGGCAGCT	0.542000													29	247					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	123988176	123988176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123988176C>T	ENST00000392744.4	+	2	1334	c.6C>T	c.(4-6)tcC>tcT	p.S2S	VWA5A_ENST00000449321.1_Intron|VWA5A_ENST00000456829.2_Intron|VWA5A_ENST00000361352.5_Intron|VWA5A_ENST00000360334.4_Intron|VWA5A_ENST00000392748.1_Intron			O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	0	VIT.									autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						CCAACATGTCCTCTGTTTGTG	0.433000													6	58					0	0	1	0	0
FAM83A	84985	broad.mit.edu	37	8	124219654	124219654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124219654C>T	ENST00000518448.1	+	5	3045	c.1031C>T	c.(1030-1032)cCc>cTc	p.P344L	FAM83A_ENST00000522648.1_Missense_Mutation_p.P288L|FAM83A_ENST00000318462.6_Missense_Mutation_p.P344L|FAM83A_ENST00000276699.6_Missense_Mutation_p.P344L|FAM83A_ENST00000536633.1_Missense_Mutation_p.P344L|FAM83A_ENST00000546351.1_Missense_Mutation_p.P288L			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	344	Ser-rich.									breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GGCAGCCACCCCGGTACCCGA	0.726000													9	22					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416761	29416761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29416761G>A	ENST00000389048.3	-	29	5098	c.4192C>T	c.(4192-4194)Ccg>Tcg	p.P1398S	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1398					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TATTCTATCGGCAAAGCGGTG	0.468000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				5	52					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886187	9886187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:9886187G>A	ENST00000306084.6	+	1	215	c.16G>A	c.(16-18)Gaa>Aaa	p.E6K	TXNDC2_ENST00000357775.4_Intron|TXNDC2_ENST00000426718.3_Missense_Mutation_p.E6K|TXNDC2_ENST00000584255.1_Intron|TXNDC2_ENST00000536353.2_Intron	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	6					cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						TGTAGACAAGGAACTAGGAAT	0.428000													6	28					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093446	30093446	+	RNA	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30093446T>G	ENST00000567636.1	+	0	1821					NR_003558.1																						CCACCCGGCTTGATTCAGCGA	0.542000													91	154					0	0	1	0	0
AP1M2	10053	broad.mit.edu	37	19	10685646	10685646	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10685646C>T	ENST00000590923.1	-	10	1196	c.1113G>A	c.(1111-1113)gaG>gaA	p.E371E	AP1M2_ENST00000250244.6_Silent_p.E369E			Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	369	MHD.				cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			endometrium(4)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	9			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			GGCCCTCCACCTCTTCCTTTT	0.617000													4	16					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115341822	115341822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115341822C>T	ENST00000351270.3	+	9	1122	c.1026C>T	c.(1024-1026)ccC>ccT	p.P342P	HABP2_ENST00000542051.1_Silent_p.P316P|HABP2_ENST00000541666.1_Intron	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	342	Peptidase S1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		TCTCCATGCCCCAGGGCCACT	0.642000													14	32					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49654453	49654453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49654453C>T	ENST00000249601.4	-	10	2374	c.2078G>A	c.(2077-2079)gGt>gAt	p.G693D	ARHGAP22_ENST00000477708.2_Missense_Mutation_p.G526D|ARHGAP22_ENST00000435790.2_Missense_Mutation_p.G699D|ARHGAP22_ENST00000374170.1_Missense_Mutation_p.G534D|ARHGAP22_ENST00000374172.1_Missense_Mutation_p.G584D|ARHGAP22_ENST00000417247.2_Missense_Mutation_p.G603D|ARHGAP22_ENST00000417912.2_Missense_Mutation_p.G709D	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	693					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GGCCCTGGCACCTTTTGCCCC	0.542000													20	85					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33954784	33954784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33954784G>A	ENST00000389232.4	+	35	5123	c.5053G>A	c.(5053-5055)Gag>Aag	p.E1685K	RYR3_ENST00000415757.3_Missense_Mutation_p.E1685K	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1685	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCAGAGCCCCGAGATTCCCTT	0.592000													33	85					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19566052	19566052	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:19566052C>T	ENST00000409832.3	+	6	1148	c.1096C>T	c.(1096-1098)Cta>Tta	p.L366L	CTD-2311B13.5_ENST00000548748.1_lincRNA	NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	366										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						AAAACAGATGCTAAAAGTCTC	0.308000													12	161					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140265500	140265500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140265500G>A	ENST00000458420.3	+	10	1841	c.1651G>A	c.(1651-1653)Gaa>Aaa	p.E551K		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	551					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						TAATTCCTTGGAAAGCCTTGG	0.557000										HNSCC(16;0.037)			11	21					0	0	1	0	0
TFCP2	7024	broad.mit.edu	37	12	51504689	51504689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51504689G>A	ENST00000307660.4	-	5	1255	c.535C>T	c.(535-537)Cct>Tct	p.P179S	TFCP2_ENST00000257915.5_Missense_Mutation_p.P179S|TFCP2_ENST00000549867.1_Missense_Mutation_p.P179S|TFCP2_ENST00000548115.1_Missense_Mutation_p.P179S	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	179	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						CTCTTTGCAGGGTCCCACAGG	0.403000													41	138					0	0	1	0	0
RPUSD4	84881	broad.mit.edu	37	11	126074205	126074205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:126074205C>T	ENST00000298317.4	-	6	868	c.815G>A	c.(814-816)cGa>cAa	p.R272Q	RPUSD4_ENST00000533628.1_Missense_Mutation_p.R241Q	NM_032795.2	NP_116184.2	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	272					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		CAAGTGAACTCGAAGCTGATG	0.413000													15	65					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13214675	13214675	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:13214675C>T	ENST00000378694.1	+	4	577	c.502C>T	c.(502-504)Cag>Tag	p.Q168*	MCM10_ENST00000378714.3_Nonsense_Mutation_p.Q168*|MCM10_ENST00000484800.2_Nonsense_Mutation_p.Q169*			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	169					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						TCAGAGAATTCAGGAGTCAAC	0.468000													8	108					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49687651	49687651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49687651G>A	ENST00000374172.1	-	3	358	c.104C>T	c.(103-105)cCt>cTt	p.P35L	ARHGAP22_ENST00000249601.4_Intron|ARHGAP22_ENST00000435790.2_Intron|ARHGAP22_ENST00000374170.1_Intron|ARHGAP22_ENST00000417247.2_Intron|ARHGAP22_ENST00000417912.2_Missense_Mutation_p.P160L			Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	151					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GGGTTCTAGAGGGTGGGCATG	0.637000													8	19					0	0	1	0	0
DHRS3	9249	broad.mit.edu	37	1	12638970	12638970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12638970G>A	ENST00000376223.2	-	4	857	c.474C>T	c.(472-474)ttC>ttT	p.F158F		NM_004753.4	NP_004744.2	O75911	DHRS3_HUMAN	dehydrogenase/reductase (SDR family) member 3	158					retinol metabolic process|visual perception	integral to membrane	electron carrier activity|NADP-retinol dehydrogenase activity|nucleotide binding			cervix(1)|large_intestine(4)|lung(2)|prostate(1)|skin(1)	9	Ovarian(185;0.249)	Lung NSC(185;4.11e-05)|all_lung(284;4.58e-05)|Renal(390;0.000147)|Colorectal(325;0.000585)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;9.25e-07)|COAD - Colon adenocarcinoma(227;0.000326)|BRCA - Breast invasive adenocarcinoma(304;0.000344)|Kidney(185;0.00235)|KIRC - Kidney renal clear cell carcinoma(229;0.00656)|STAD - Stomach adenocarcinoma(313;0.00798)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	TACGTGGCAGGAAGGCCTTGG	0.622000													7	34					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68398989	68398989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68398989C>T	ENST00000219334.5	-	4	1933	c.1330G>A	c.(1330-1332)Gtg>Atg	p.V444M	SMPD3_ENST00000566009.1_5'UTR|SMPD3_ENST00000563226.1_Missense_Mutation_p.V444M|SMPD3_ENST00000568373.1_Missense_Mutation_p.V444M	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	444					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	GTGCTTCCCACCTGCACCTGG	0.617000													12	35					0	0	1	0	0
NPFFR1	64106	broad.mit.edu	37	10	72026113	72026113	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72026113G>A	ENST00000277942.5	-	2	49	c.42C>T	c.(40-42)ccC>ccT	p.P14P		NM_022146.4	NP_071429.1	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1	14						integral to membrane|plasma membrane	neuropeptide receptor activity			endometrium(2)|lung(1)	3						TCTGACTTAGGGGCCAACTGC	0.537000													8	15					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97192238	97192238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97192238G>A	ENST00000371247.2	-	6	457	c.268C>T	c.(268-270)Cct>Tct	p.P90S	SORBS1_ENST00000361941.3_Missense_Mutation_p.P90S|SORBS1_ENST00000393949.1_Missense_Mutation_p.P90S|SORBS1_ENST00000354106.3_Missense_Mutation_p.P90S|SORBS1_ENST00000371245.3_Missense_Mutation_p.P90S|SORBS1_ENST00000371227.4_Missense_Mutation_p.P90S|SORBS1_ENST00000371241.1_Missense_Mutation_p.P58S|SORBS1_ENST00000607232.1_Missense_Mutation_p.P58S|SORBS1_ENST00000306402.6_Missense_Mutation_p.P90S|SORBS1_ENST00000371249.2_Missense_Mutation_p.P58S|SORBS1_ENST00000371239.1_Missense_Mutation_p.P58S|SORBS1_ENST00000347291.4_Missense_Mutation_p.P90S|SORBS1_ENST00000277982.5_Missense_Mutation_p.P90S|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000353505.5_Missense_Mutation_p.P90S|SORBS1_ENST00000371246.2_Missense_Mutation_p.P90S			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	90					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GTTTCCTGAGGGCTCGCAGGG	0.572000													26	119					0	0	1	0	0
SYT7	9066	broad.mit.edu	37	11	61290624	61290624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61290624C>T	ENST00000263846.4	-	8	1357	c.1030G>A	c.(1030-1032)Gag>Aag	p.E344K	SYT7_ENST00000535826.1_Missense_Mutation_p.E463K|SYT7_ENST00000542836.1_Missense_Mutation_p.E388K|SYT7_ENST00000539008.1_Missense_Mutation_p.E627K|SYT7_ENST00000540677.1_Missense_Mutation_p.E419K|SYT7_ENST00000542670.1_Missense_Mutation_p.E552K	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	344	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CTCAGCTTCTCCGTGGGGATA	0.547000													30	94					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18762339	18762339	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18762339C>T	ENST00000396170.1	-	8	1894	c.629_splice	c.e8-1	p.R210_splice	PTPN5_ENST00000477854.1_Splice_Site_p.R46_splice|PTPN5_ENST00000358540.2_Splice_Site_p.R242_splice|PTPN5_ENST00000396171.4_Splice_Site_p.R242_splice|PTPN5_ENST00000496201.2_5'UTR|PTPN5_ENST00000396167.2_Splice_Site_p.R210_splice|PTPN5_ENST00000396168.1_Splice_Site_p.R218_splice	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	242						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						TGGAACCCCTCCTGGAAGGAC	0.627000													9	30					0	0	1	0	0
HERC3	8916	broad.mit.edu	37	4	89574082	89574082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89574082C>T	ENST00000402738.1	+	6	765	c.526C>T	c.(526-528)Ccc>Tcc	p.P176S	HERC3_ENST00000264345.3_Missense_Mutation_p.P176S|HERC3_ENST00000407637.1_Missense_Mutation_p.P176S	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	176					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		GAAGGAGTTCCCCTCCCAAGC	0.562000													15	36					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323749	44323749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:44323749C>T	ENST00000354250.2	+	3	696	c.627C>T	c.(625-627)acC>acT	p.T209T	NDUFV3_ENST00000460259.1_3'UTR|NDUFV3_ENST00000340344.3_Intron	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	40					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	AAGAGAAAACCTTGCTGCAGA	0.522000													14	119					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6953077	6953077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6953077G>A	ENST00000229264.3	+	9	1039	c.634G>A	c.(634-636)Gat>Aat	p.D212N	GNB3_ENST00000435982.2_Missense_Mutation_p.D211N	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	212					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						CAAGCTCTGGGATGTGCGAGA	0.577000													27	77					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63059015	63059015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63059015G>A	ENST00000332793.6	+	2	408	c.406G>A	c.(406-408)Gac>Aac	p.D136N	SLC22A10_ENST00000544661.1_5'UTR|SLC22A10_ENST00000526800.1_Missense_Mutation_p.D84N|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	136						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTTCCAGTGGGACCTGGTATG	0.463000													16	45					0	0	1	0	0
PITX1	5307	broad.mit.edu	37	5	134364788	134364788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134364788G>A	ENST00000265340.7	-	3	1042	c.626C>T	c.(625-627)tCg>tTg	p.S209L	PITX1_ENST00000506438.1_Missense_Mutation_p.S209L	NM_002653.4	NP_002644.4	P78337	PITX1_HUMAN	paired-like homeodomain 1	209	Interacts with PIT-1 (By similarity).					nucleolus	sequence-specific DNA binding			central_nervous_system(1)|cervix(3)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	READ - Rectum adenocarcinoma(2;0.0607)		GGACTGCGACGACAGCGGGCT	0.652000													16	80					0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77457903	77457903	+	Missense_Mutation	SNP	G	G	A	rs138457062	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:77457903G>A	ENST00000299543.7	+	4	683	c.536G>A	c.(535-537)cGa>cAa	p.R179Q	CTDP1_ENST00000075430.7_Missense_Mutation_p.R179Q	NM_001202504.1|NM_004715.4	NP_001189433.1|NP_004706.3	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	179	FCP1 homology.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CGACTGCACCGAAACCGGAAG	0.473000													20	42					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156834207	156834207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156834207G>A	ENST00000368196.3	+	2	394	c.274G>A	c.(274-276)Gag>Aag	p.E92K	NTRK1_ENST00000358660.3_Missense_Mutation_p.E92K|NTRK1_ENST00000392302.2_Missense_Mutation_p.E62K|NTRK1_ENST00000524377.1_Missense_Mutation_p.E92K	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	92					activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GGGCCTGGGGGAGCTGAGAAA	0.637000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			12	29					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27681043	27681043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27681043G>A	ENST00000260570.3	-	27	3028	c.2925C>T	c.(2923-2925)atC>atT	p.I975I		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	975					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GGGCCTGAGTGATGTATAGCA	0.552000													11	121					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559734	140559734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140559734C>T	ENST00000239444.2	+	1	2364	c.2119C>T	c.(2119-2121)Ctc>Ttc	p.L707F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		707					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTCTCGGTGCTCCTGTTCGT	0.672000													46	200					0	0	1	0	0
KIAA0825	285600	broad.mit.edu	37	5	93856513	93856513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:93856513G>A	ENST00000513200.3	-	4	482	c.410C>T	c.(409-411)tCt>tTt	p.S137F	KIAA0825_ENST00000312498.7_Missense_Mutation_p.S137F|KIAA0825_ENST00000427991.2_Missense_Mutation_p.S137F|KIAA0825_ENST00000329378.7_Missense_Mutation_p.S137F	NM_001145678.1	NP_001139150.1	Q8IV33	K0825_HUMAN	KIAA0825	137										breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|pancreas(1)|prostate(1)|skin(1)	13						GAAATGGAAAGATGTTCCACT	0.413000													13	42					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233655986	233655986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233655986C>T	ENST00000373566.3	+	13	1375	c.1178C>T	c.(1177-1179)cCc>cTc	p.P393L	GIGYF2_ENST00000409451.3_Missense_Mutation_p.P392L|GIGYF2_ENST00000452341.2_Missense_Mutation_p.P202L|GIGYF2_ENST00000409547.1_Missense_Mutation_p.P371L|GIGYF2_ENST00000409480.1_Missense_Mutation_p.P393L|GIGYF2_ENST00000373563.4_Missense_Mutation_p.P371L|GIGYF2_ENST00000409196.3_Missense_Mutation_p.P365L			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	371					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GAGGAAACTCCCCAGACCTCA	0.438000													36	78					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38424437	38424437	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38424437G>A	ENST00000356264.2	-	21	2285	c.2070C>T	c.(2068-2070)ttC>ttT	p.F690F	AMPH_ENST00000428293.2_Silent_p.F648F|AMPH_ENST00000325590.5_Silent_p.F648F	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	690	SH3.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						AGCGTCGGGTGAAGTTCTCTG	0.458000													29	101					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169747	57169747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57169747G>A	ENST00000371244.4	+	7	958	c.892G>A	c.(892-894)Gaa>Aaa	p.E298K		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	298					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						AGAAGTGTGTGAAAAATTTGA	0.383000													77	179					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52799986	52799986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52799986G>A	ENST00000257974.2	-	1	153	c.76C>T	c.(76-78)Cgg>Tgg	p.R26W		NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	26	Head.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		GTGACCATCCGGGGCATGACA	0.622000													4	32					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56233058	56233058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56233058C>T	ENST00000268912.5	+	1	565	c.544C>T	c.(544-546)Ccc>Tcc	p.P182S		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						CTGTGATGTTCCCCAAGTACT	0.517000													46	113					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10379965	10379965	+	Silent	SNP	C	C	T	rs141820572		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10379965C>T	ENST00000397077.1	-	21	3755	c.3180G>A	c.(3178-3180)ccG>ccA	p.P1060P	ATP2B2_ENST00000352432.4_Silent_p.P1105P|ATP2B2_ENST00000343816.4_Silent_p.P1091P|ATP2B2_ENST00000383800.4_Silent_p.P1060P|ATP2B2_ENST00000360273.2_Silent_p.P1105P			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	1105					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GCTCCTCCTCCGGGATCTCCT	0.632000													18	98					0	0	1	0	0
GPR20	2843	broad.mit.edu	37	8	142367098	142367098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142367098C>T	ENST00000377741.3	-	2	1016	c.926G>A	c.(925-927)cGa>cAa	p.R309Q		NM_005293.2	NP_005284.2	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	309						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(3)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	15	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			GAAGAGGCCTCGGACGGTGGC	0.637000													8	53					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148951279	148951279	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148951279A>G	ENST00000335870.2	+	5	1389	c.1261A>G	c.(1261-1263)Agg>Ggg	p.R421G		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			CATCCCTTGGAGGAAAAGCCG	0.622000													15	33					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69472489	69472489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69472489C>T	ENST00000303714.4	+	18	1889	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	523	Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						ccactgccctcccccgccccc	0.701000									Familial Infantile Hemangioma				4	7					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369377	56369377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56369377C>T	ENST00000301295.6	+	3	1040	c.618C>T	c.(616-618)tcC>tcT	p.S206S	NLRP4_ENST00000346986.5_Silent_p.S206S|NLRP4_ENST00000587891.1_Silent_p.S131S	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	206	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ACTTGATTTCCAGAGAGTGGC	0.532000													12	137					0	0	1	0	0
C5orf46	389336	broad.mit.edu	37	5	147281256	147281256	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147281256G>A	ENST00000515291.1	-	2	187	c.151C>T	c.(151-153)Ctc>Ttc	p.L51F	C5orf46_ENST00000318315.4_Missense_Mutation_p.L51F|C5orf46_ENST00000510432.1_5'UTR			Q6UWT4	CE046_HUMAN	chromosome 5 open reading frame 46	51						extracellular region				NS(1)|lung(1)|prostate(1)	3						GTGCCCAGGAGGCTTAGGAAT	0.493000													10	58					0	0	1	0	0
PRRX1	5396	broad.mit.edu	37	1	170688909	170688909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:170688909G>A	ENST00000239461.6	+	2	597	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	PRRX1_ENST00000497230.2_Missense_Mutation_p.R95Q|PRRX1_ENST00000367760.3_Missense_Mutation_p.R95Q	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	95						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGAAAGCAGCGAAGGAATAGG	0.458000													9	29					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212798992	212798992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:212798992C>T	ENST00000294829.3	+	1	1204	c.773C>T	c.(772-774)tCc>tTc	p.S258F	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	258										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CTCAATGCATCCATCCCCAAA	0.552000													53	125					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29650615	29650615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:29650615C>T	ENST00000318184.5	-	1	4	c.5G>A	c.(4-6)gGc>gAc	p.G2D		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	2					proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GGCCAGCAGGCCCATAGCCTC	0.652000													9	54					0	0	1	0	0
OAT	4942	broad.mit.edu	37	10	126092381	126092381	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:126092381A>G	ENST00000368845.5	-	6	849	c.757T>C	c.(757-759)Tgc>Cgc	p.C253R	OAT_ENST00000467675.1_5'UTR|OAT_ENST00000539214.1_Missense_Mutation_p.C115R	NM_000274.3	NP_000265.1	P04181	OAT_HUMAN	ornithine aminotransferase	253					cellular amino acid biosynthetic process|visual perception	mitochondrial matrix	ornithine-oxo-acid transaminase activity|protein binding|pyridoxal phosphate binding			endometrium(2)|large_intestine(1)|lung(2)	5		all_lung(145;0.0271)|Lung NSC(174;0.0436)|Colorectal(57;0.102)|all_neural(114;0.116)			L-Ornithine(DB00129)|Pyridoxal Phosphate(DB00114)	TGCCTGGTGCAGAGCTCTCGC	0.517000											OREG0020605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	38					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831698	61831698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61831698C>T	ENST00000280772.1	-	37	9132	c.8941G>A	c.(8941-8943)Gaa>Aaa	p.E2981K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2981					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCCGACTGTTCACAAAAACCA	0.438000													28	61					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124761637	124761637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124761637C>T	ENST00000306534.3	-	11	2094	c.1609G>A	c.(1609-1611)Gac>Aac	p.D537N	RP11-664I21.6_ENST00000524433.1_Intron|ROBO4_ENST00000533054.1_Missense_Mutation_p.D392N	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	537					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CTGCTCAGGTCCCGAGAGCCA	0.647000													16	32					0	0	1	0	0
IGHV3-53	28420	broad.mit.edu	37	14	107048762	107048762	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107048762G>A	ENST00000390627.2	-	0	478																											TGGAGATGGTGAATCGGCCCT	0.542000													52	393					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130162345	130162345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130162345G>A	ENST00000265379.6	+	36	7007	c.6513G>A	c.(6511-6513)ccG>ccA	p.P2171P	COL6A5_ENST00000432398.2_Silent_p.P2171P			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2171	Nonhelical region.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						ACCCACCACCGATGCTTGAGG	0.373000													22	52					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80633209	80633209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80633209G>A	ENST00000458043.2	+	10	1021	c.1015G>A	c.(1015-1017)Gat>Aat	p.D339N	OTOGL_ENST00000547103.1_Missense_Mutation_p.D339N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CTGTGTTAATGATCTTTGCAA	0.353000													23	73					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4808358	4808358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4808358G>A	ENST00000354582.6	+	44	5994	c.5644G>A	c.(5644-5646)Gat>Aat	p.D1882N	ITPR1_ENST00000302640.8_Missense_Mutation_p.D1882N|ITPR1_ENST00000456211.2_Missense_Mutation_p.D1834N|ITPR1_ENST00000423119.2_Missense_Mutation_p.D1849N|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.D1849N|ITPR1_ENST00000443694.2_Missense_Mutation_p.D1882N			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1897					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AAAGAAAGACGATGAGGTAGA	0.438000													21	37					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168180991	168180991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168180991G>A	ENST00000519560.1	-	17	2126	c.1707C>T	c.(1705-1707)atC>atT	p.I569I	SLIT3_ENST00000332966.8_Silent_p.I569I|SLIT3_ENST00000404867.3_Silent_p.I569I	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	569					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCACCTCCTTGATCTTATTGT	0.547000													8	11					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62582306	62582306	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62582306G>A	ENST00000371158.2	+	36	4872	c.4758G>A	c.(4756-4758)gaG>gaA	p.E1586E	INADL_ENST00000543708.1_Silent_p.E400E	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1586	PDZ 9.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TGAATGGGGAGGACATGAGAA	0.512000													10	60					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87145863	87145863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87145863G>A	ENST00000265724.3	-	25	3463	c.3046C>T	c.(3046-3048)Cct>Tct	p.P1016S	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Missense_Mutation_p.P952S	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1016					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCAATCAAAGGGGTTTTTTCA	0.448000													31	107					0	0	1	0	0
NPS	594857	broad.mit.edu	37	10	129347818	129347818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129347818C>T	ENST00000398023.1	+	2	94	c.74C>T	c.(73-75)cCa>cTa	p.P25L		NM_001030013.1	NP_001025184.1	P0C0P6	NPS_HUMAN	neuropeptide S	25					neuropeptide signaling pathway	extracellular region				haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						TGGTGTTATCCAGTTCCATCT	0.343000													22	66					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62293078	62293078	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62293078A>G	ENST00000378024.4	-	5	9085	c.8811T>C	c.(8809-8811)gtT>gtC	p.V2937V	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2937					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTTCAATGTTAACATCAGGGC	0.517000													117	243					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78223041	78223041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78223041G>A	ENST00000361193.3	+	16	1891	c.1611G>A	c.(1609-1611)caG>caA	p.Q537Q	SLC26A11_ENST00000411502.3_Silent_p.Q537Q|SLC26A11_ENST00000572725.1_Silent_p.Q537Q|SLC26A11_ENST00000546047.2_Silent_p.Q537Q	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	537	STAS.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AGCTCCTCCAGGACTTCCAGA	0.652000													10	32					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45958907	45958907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45958907C>T	ENST00000402984.3	+	16	2030	c.1927C>T	c.(1927-1929)Cgc>Tgc	p.R643C	FBLN1_ENST00000442170.2_Intron|FBLN1_ENST00000348697.2_Intron|FBLN1_ENST00000327858.6_Intron|FBLN1_ENST00000262722.7_Missense_Mutation_p.R605C			P23142	FBLN1_HUMAN	fibulin 1	618					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GGTGGTTTTCCGCATGGGCCC	0.617000													67	172					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367863	107367863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107367863C>T	ENST00000542196.1	-	1	88	c.46G>A	c.(46-48)Gga>Aga	p.G16R		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CCAGAAAGTCCCTTCAGAAAA	0.368000													16	77					0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84796646	84796646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84796646C>T	ENST00000219473.7	+	9	1719	c.1606C>T	c.(1606-1608)Cat>Tat	p.H536Y	USP10_ENST00000570191.1_Missense_Mutation_p.H540Y	NM_001272075.1|NM_005153.2	NP_001259004.1|NP_005144.2	Q14694	UBP10_HUMAN	ubiquitin specific peptidase 10	536					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						AAATGGACTTCATGAGGAAAT	0.408000													38	137					0	0	1	0	0
AGBL4	84871	broad.mit.edu	37	1	49052746	49052746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:49052746G>A	ENST00000371839.1	-	11	1313	c.1197C>T	c.(1195-1197)acC>acT	p.T399T	AGBL4_ENST00000334103.7_Silent_p.T132T	NM_032785.3	NP_116174.3	Q5VU57	CBPC6_HUMAN	ATP/GTP binding protein-like 4	399					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15				Colorectal(2;0.00349)|COAD - Colon adenocarcinoma(2;0.0037)		AGACCTCTAGGGTGTAGCAAT	0.562000													4	2					0	0	1	0	0
AMPD2	271	broad.mit.edu	37	1	110163726	110163726	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110163726T>C	ENST00000256578.3	+	1	451	c.91T>C	c.(91-93)Ttg>Ctg	p.L31L	AMPD2_ENST00000342115.4_Intron|AMPD2_ENST00000526301.1_Intron|AMPD2_ENST00000358729.4_5'UTR|AMPD2_ENST00000528667.1_Silent_p.L31L	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	31					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		GAGGAAGGGGTTGGATGTGGC	0.672000													4	16					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602718	96602718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96602718C>T	ENST00000371321.3	+	7	1168	c.1086C>T	c.(1084-1086)atC>atT	p.I362I	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	362					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TCGACCTCATCCCCACCAGCC	0.537000													44	139					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56435862	56435862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:56435862C>T	ENST00000327381.5	+	3	1129	c.1029C>T	c.(1027-1029)ctC>ctT	p.L343L		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	343						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			CAGCTTCCCTCGTGTCCCTGG	0.572000													12	16					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074292	106074292	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106074292G>A	ENST00000278071.2	-	3	1970	c.1518C>T	c.(1516-1518)ttC>ttT	p.F506F	ITPRIP_ENST00000358187.2_Silent_p.F506F|ITPRIP_ENST00000337478.1_Silent_p.F506F	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	506						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						GCTGCAGGACGAAGGGCCGGA	0.587000													24	89					0	0	1	0	0
DEFB118	117285	broad.mit.edu	37	20	29960755	29960755	+	Nonsense_Mutation	SNP	C	C	T	rs34328728		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:29960755C>T	ENST00000253381.2	+	2	187	c.154C>T	c.(154-156)Cga>Tga	p.R52*		NM_054112.2	NP_473453.1	Q96PH6	DB118_HUMAN	defensin, beta 118	52					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				breast(1)|endometrium(1)|lung(7)|ovary(3)|pancreas(1)|prostate(1)	14	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CAAAAATCTTCGAGCTTGCTG	0.438000													40	80					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925636	27925636	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:27925636C>T	ENST00000244623.1	+	1	618	c.618C>T	c.(616-618)ttC>ttT	p.F206F		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GTGAGCTCTTCCATCTAATAC	0.423000													63	206					0	0	1	0	0
FOXR1	283150	broad.mit.edu	37	11	118850327	118850327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118850327G>A	ENST00000317011.3	+	4	785	c.560G>A	c.(559-561)aGa>aAa	p.R187K		NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1	187					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CTGGCATTAAGAAACAGTTCC	0.637000													44	111					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42196398	42196398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42196398G>A	ENST00000541110.1	-	18	3916	c.3348C>T	c.(3346-3348)ttC>ttT	p.F1116F	TRERF1_ENST00000354325.2_Silent_p.F1013F|TRERF1_ENST00000340840.2_Silent_p.F1025F|TRERF1_ENST00000372917.4_Silent_p.F1025F|TRERF1_ENST00000372922.4_Silent_p.F1096F			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1096	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TTTTGATCTTGAAGAAGACTC	0.468000													159	344					0	0	1	0	0
LPCAT1	79888	broad.mit.edu	37	5	1474126	1474126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1474126G>A	ENST00000283415.3	-	11	1257	c.1125C>T	c.(1123-1125)tcC>tcT	p.S375S		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	375					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		GGACTTCCAGGGAGGCGGCAA	0.532000													19	34					0	0	1	0	0
YTHDF2	51441	broad.mit.edu	37	1	29070059	29070059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:29070059C>T	ENST00000373812.3	+	4	1639	c.1277C>T	c.(1276-1278)tCc>tTc	p.S426F	YTHDF2_ENST00000542507.1_Missense_Mutation_p.S426F|YTHDF2_ENST00000541996.1_Missense_Mutation_p.S376F|YTHDF2_ENST00000478283.1_3'UTR	NM_016258.2	NP_057342.2	Q9Y5A9	YTHD2_HUMAN	YTH domain family, member 2	426	YTH.				humoral immune response					NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		ATTCACCGTTCCATTAAGTAT	0.423000													9	104					0	0	1	0	0
MSH5-SAPCD1	100532732	broad.mit.edu	37	6	31728484	31728484	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31728484C>T	ENST00000493662.2	+	20	1937	c.1881C>T	c.(1879-1881)ttC>ttT	p.F627F	MSH5_ENST00000395853.1_Silent_p.F284F|MSH5_ENST00000375750.3_Silent_p.F610F|MSH5_ENST00000375755.3_Silent_p.F610F|MSH5_ENST00000431848.2_Silent_p.F309F|MSH5_ENST00000375703.3_Silent_p.F610F|MSH5_ENST00000375740.3_Silent_p.F627F|MSH5_ENST00000534153.4_Silent_p.F627F|MSH5_ENST00000375742.3_Silent_p.F627F																							TGATCACATTCATGGCCCTGG	0.557000													44	99					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62039787	62039787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62039787C>T	ENST00000354587.3	-	16	2066	c.1890G>A	c.(1888-1890)cgG>cgA	p.R630R	KCNQ2_ENST00000359125.2_Silent_p.R622R|KCNQ2_ENST00000360480.3_Silent_p.R594R|KCNQ2_ENST00000430658.1_Silent_p.R591R|KCNQ2_ENST00000344462.3_Silent_p.R618R|KCNQ2_ENST00000359689.1_Silent_p.R622R|KCNQ2_ENST00000370224.1_Silent_p.R630R|KCNQ2_ENST00000357249.2_Silent_p.R604R|KCNQ2_ENST00000370226.1_Silent_p.R592R			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	622					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CCTTCCCGAGCCGTCCCATCA	0.706000													6	19					0	0	1	0	0
OR6C70	390327	broad.mit.edu	37	12	55863470	55863470	+	Silent	SNP	G	G	A	rs147384913		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55863470G>A	ENST00000327335.4	-	1	452	c.453C>T	c.(451-453)ttC>ttT	p.F151F	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA	NM_001005499.1	NP_001005499.1	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C, member 70	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F151F(1)		autonomic_ganglia(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	18						AAATGATCAGGAATCCAGTTA	0.368000													24	60					0	0	1	0	0
SERPINA11	256394	broad.mit.edu	37	14	94909498	94909498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94909498G>A	ENST00000334708.3	-	4	1046	c.982C>T	c.(982-984)Ccc>Tcc	p.P328S	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	328					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		CCAATTTGGGGAAGTATGTCT	0.438000													33	88					0	0	1	0	0
TMEM190	147744	broad.mit.edu	37	19	55889357	55889357	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55889357G>A	ENST00000291934.3	+	5	338	c.320G>A	c.(319-321)cGg>cAg	p.R107Q	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	107						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GCCAAGCGCCGGGACGTGCTG	0.711000													13	35					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	375943	375943	+	Missense_Mutation	SNP	C	C	T	rs141910884		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:375943C>T	ENST00000342640.4	-	1	70	c.28G>A	c.(28-30)Ggg>Agg	p.G10R	THEG_ENST00000346878.2_Missense_Mutation_p.G10R	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	10					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGTTCCCGAGTGACCTT	0.692000													12	62					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656605	19656605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19656605C>T	ENST00000586018.1	+	8	3371	c.3269C>T	c.(3268-3270)tCc>tTc	p.S1090F	CILP2_ENST00000291495.4_Missense_Mutation_p.S1084F			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1084						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						TTTGATGGTTCCTCTGACGGC	0.627000													9	14					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774681	121774681	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121774681C>T	ENST00000264808.3	-	3	432	c.192G>A	c.(190-192)aaG>aaA	p.K64K	PRDM5_ENST00000428209.2_Silent_p.K64K|PRDM5_ENST00000515109.1_Silent_p.K64K|PRDM5_ENST00000394435.2_Silent_p.K64K	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	64	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AAACTTCTCCCTTACTCCCAC	0.448000													28	338					0	0	1	0	0
CLDN8	9073	broad.mit.edu	37	21	31587956	31587956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31587956C>T	ENST00000399899.1	-	1	435	c.288G>A	c.(286-288)atG>atA	p.M96I	CLDN8_ENST00000286809.1_Missense_Mutation_p.M96I	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	96					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						GGATGGCCATCATGAAAGCCA	0.522000													17	49					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230902211	230902211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230902211G>A	ENST00000295190.4	-	5	1876	c.1418C>T	c.(1417-1419)tCc>tTc	p.S473F		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	473						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TATGTAGAAGGAAAAATCATA	0.323000													20	47					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165602	151165602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151165602C>T	ENST00000282466.3	-	4	2166	c.2167G>A	c.(2167-2169)Gaa>Aaa	p.E723K		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	723					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGTGTTAATTCCCGATAGTTG	0.493000													28	46					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67260957	67260957	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67260957A>G	ENST00000392676.3	-	24	3298	c.3234T>C	c.(3232-3234)ttT>ttC	p.F1078F	ABCA5_ENST00000392677.2_Silent_p.F1079F|ABCA5_ENST00000588877.1_Silent_p.F1078F			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	1078					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					TAAGAATGATAAAAAATAAGG	0.308000													26	95					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35832673	35832673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35832673C>T	ENST00000085219.5	+	9	1906	c.1840C>T	c.(1840-1842)Ctg>Ttg	p.L614L	CD22_ENST00000419549.2_Silent_p.L442L|CD22_ENST00000341773.6_Silent_p.L437L|CD22_ENST00000536635.2_Silent_p.L526L|CD22_ENST00000270311.6_Silent_p.L494L|CD22_ENST00000544992.2_Silent_p.L614L|CD22_ENST00000594250.1_Silent_p.L437L	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	614	Ig-like C2-type 6.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GAGTGCAACCCTGACCTGTGA	0.617000													14	46					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105833949	105833949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105833949C>T	ENST00000353479.5	-	6	662	c.372G>A	c.(370-372)aaG>aaA	p.K124K	COL17A1_ENST00000369733.3_Silent_p.K124K|COL17A1_ENST00000393211.3_Silent_p.K124K	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	124	Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TACCAAATTCCTTCCGAGGGT	0.488000													52	117					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61659025	61659025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:61659025G>A	ENST00000381103.2	+	14	1565	c.1080G>A	c.(1078-1080)agG>agA	p.R360R	KIF2A_ENST00000407818.3_Silent_p.R380R|KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000401507.3_Silent_p.R380R|KIF2A_ENST00000506857.1_Silent_p.R334R	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	380	Kinesin-motor.				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		TGCTAAACAGGAAAACAAAAT	0.378000													4	13					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248039286	248039286	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248039286G>A	ENST00000366481.3	+	6	1004	c.956G>A	c.(955-957)tGg>tAg	p.W319*	OR2W3_ENST00000537741.1_5'UTR	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	319	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGAGAACCATGGAGGGATGTC	0.582000													21	33					0	0	1	0	0
REEP3	221035	broad.mit.edu	37	10	65379551	65379551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:65379551C>T	ENST00000373758.4	+	7	885	c.702C>T	c.(700-702)ggC>ggT	p.G234G	REEP3_ENST00000298249.4_Silent_p.G219G	NM_001001330.2	NP_001001330.1	Q6NUK4	REEP3_HUMAN	receptor accessory protein 3	234						integral to membrane				endometrium(1)|large_intestine(2)|lung(3)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCACCAAAGGCCGCAAAGAGG	0.398000													4	13					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25684929	25684929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25684929G>A	ENST00000376351.3	+	3	1457	c.1098G>A	c.(1096-1098)gtG>gtA	p.V366V		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	366						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TCTTACCAGTGAACAACTTTC	0.358000													13	37					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541132	55541132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55541132C>T	ENST00000361760.1	+	1	219	c.219C>T	c.(217-219)ttC>ttT	p.F73F		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TGACAGACTTCTGTTTTTCCA	0.388000													39	110					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45410212	45410212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45410212C>T	ENST00000332700.6	-	4	1048	c.877G>A	c.(877-879)Gag>Aag	p.E293K		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	293						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GGAGAATTCTCCCTCCATCTT	0.498000													34	77					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170076982	170076982	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170076982G>C	ENST00000263816.3	-	34	5915	c.5630C>G	c.(5629-5631)aCt>aGt	p.T1877S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1877					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGGATCAACAGTTATGCCAAT	0.418000													20	47					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172062837	172062837	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:172062837G>A	ENST00000355305.5	+	14	1704	c.1545_splice	c.e14-1	p.G516_splice	DNM3_ENST00000367733.2_Intron|DNM3_ENST00000520906.1_Intron|DNM3_ENST00000367731.1_Intron|DNM3_ENST00000358155.4_Intron			Q9UQ16	DYN3_HUMAN	dynamin 3	516	PH.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CTATTTCAGGGAACCAATCTT	0.333000													19	77					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52496389	52496389	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52496389C>T	ENST00000216286.5	-	10	2276	c.2277G>A	c.(2275-2277)ccG>ccA	p.P759P	NID2_ENST00000541773.1_Silent_p.P706P	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	759	EGF-like 2.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					AAGGATTCCCCGGAGTGGGGT	0.517000													8	40					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58260778	58260778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58260778G>A	ENST00000300896.4	-	31	4065	c.3871C>T	c.(3871-3873)Cgg>Tgg	p.R1291W	USP32_ENST00000592339.1_Missense_Mutation_p.R961W	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1291					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TTTATCCACCGACCATTTACA	0.378000													35	80					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45664637	45664637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45664637C>T	ENST00000322157.4	+	9	1259	c.1022C>T	c.(1021-1023)tCa>tTa	p.S341L	NPEPPS_ENST00000525037.1_3'UTR|NPEPPS_ENST00000544660.1_Missense_Mutation_p.S261L|NPEPPS_ENST00000530173.1_Missense_Mutation_p.S337L	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	341					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						TCCTGTTCTTCATCCCGCCAG	0.353000													3	13					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178682	65178682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:65178682G>A	ENST00000310045.7	-	2	4667	c.3194C>T	c.(3193-3195)cCa>cTa	p.P1065L	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1055						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				TAAATGCTCTGGTACATTCTT	0.358000													26	50					0	0	1	0	0
COX4I1	1327	broad.mit.edu	37	16	85840354	85840354	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:85840354C>T	ENST00000562336.1	+	5	577	c.384C>T	c.(382-384)ccC>ccT	p.P128P	COX4I1_ENST00000561569.1_Silent_p.P128P|COX4I1_ENST00000564903.1_3'UTR|COX4I1_ENST00000253452.2_Silent_p.P128P|COX4I1_ENST00000568794.1_3'UTR			P13073	COX41_HUMAN	cytochrome c oxidase subunit IV isoform 1	128					respiratory electron transport chain	mitochondrial inner membrane|nucleus	cytochrome-c oxidase activity|protein binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9		Renal(780;0.228)				TGTACGGCCCCCTCCCGCAAA	0.542000													22	64					0	0	1	0	0
DPYSL3	1809	broad.mit.edu	37	5	146785234	146785234	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:146785234G>A	ENST00000343218.5	-	8	1289	c.1092C>T	c.(1090-1092)ctC>ctT	p.L364L	DPYSL3_ENST00000398514.3_Silent_p.L250L|DPYSL3_ENST00000534907.1_Intron	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	250					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTGACGTAGAGAGGGCAAT	0.498000													102	224					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32020753	32020753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32020753G>A	ENST00000375244.3	-	26	9010	c.8809C>T	c.(8809-8811)Ccc>Tcc	p.P2937S	TNXB_ENST00000375247.2_Missense_Mutation_p.P2935S			P22105	TENX_HUMAN	tenascin XB	2982	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GTGGGGGCGGGAGTTTCTTCC	0.642000													18	53					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43508587	43508587	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43508587G>A	ENST00000300215.3	-	2	622	c.165C>T	c.(163-165)gcC>gcT	p.A55A	EPB42_ENST00000540029.1_Silent_p.A25A|EPB42_ENST00000441366.2_Silent_p.A25A			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	25					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GGGAGCTGAGGGCCTTGGTGT	0.562000													9	95					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170964646	170964646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:170964646G>A	ENST00000367759.4	+	13	1465	c.1311G>A	c.(1309-1311)ctG>ctA	p.L437L	MROH9_ENST00000367758.3_Silent_p.L437L	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		ACAGTGAGCTGAAACCGATAC	0.458000													27	70					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22061092	22061092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:22061092G>A	ENST00000261200.4	-	9	1373	c.1374C>T	c.(1372-1374)gtC>gtT	p.V458V	ABCC9_ENST00000261201.4_Silent_p.V458V|ABCC9_ENST00000345162.2_Silent_p.V458V	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	458	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGCTGCACCGACCAATGCAC	0.413000													21	40					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7776939	7776939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7776939G>A	ENST00000358415.4	+	15	2008	c.1842G>A	c.(1840-1842)caG>caA	p.Q614Q	ITIH2_ENST00000379587.4_Silent_p.Q603Q	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	614					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CGATCCTGCAGATGTCTCTAG	0.552000													34	94					0	0	1	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940552	67940552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:67940552G>A	ENST00000357461.2	-	3	498	c.89C>T	c.(88-90)gCc>gTc	p.A30V	TMEM229B_ENST00000557006.1_Missense_Mutation_p.A30V	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	30						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						GAACTCCCAGGCCGCTGTGAA	0.627000													8	21					0	0	1	0	0
PELO	53918	broad.mit.edu	37	5	52096834	52096834	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52096834A>T	ENST00000274311.2	+	2	1591	c.606A>T	c.(604-606)gtA>gtT	p.V202V	ITGA1_ENST00000282588.6_Intron|ITGA1_ENST00000504086.1_Intron|PELO_ENST00000506949.1_Intron	NM_015946.4	NP_057030.3	Q9BRX2	PELO_HUMAN	pelota homolog (Drosophila)	202					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	11		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				TTGATGTTGTAAAGTGCATCC	0.517000													41	78					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45015121	45015121	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45015121G>A	ENST00000454753.1	-	0	1983							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				TTGGCACAGTGGAGACCAATC	0.493000													15	41					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159650906	159650906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159650906C>T	ENST00000297267.9	+	10	1440	c.1240C>T	c.(1240-1242)Cct>Tct	p.P414S	FNDC1_ENST00000340366.6_Intron	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	414	Fibronectin type-III 4.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CCTCACCTATCCTGGAGACAC	0.507000													29	232					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155171642	155171642	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:155171642G>A	ENST00000262640.6	+	7	705	c.622G>A	c.(622-624)Gat>Aat	p.D208N	VAMP7_ENST00000286448.6_3'UTR|VAMP7_ENST00000460621.1_3'UTR	NM_001185183.1	NP_001172112.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	0					calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATTAACCAAGGATATGAGAGA	0.408000													11	47					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064875	7064875	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7064875C>T	ENST00000299481.4	+	4	1964	c.1618C>T	c.(1618-1620)Cga>Tga	p.R540*		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	540					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GAATGAAGATCGAGTAAAACA	0.348000													31	89					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54612349	54612349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:54612349G>A	ENST00000302287.3	+	2	520	c.114G>A	c.(112-114)gcG>gcA	p.A38A	VSTM2A_ENST00000402613.3_Silent_p.A38A|VSTM2A_ENST00000402026.2_Silent_p.A37A|VSTM2A_ENST00000404951.1_Silent_p.A38A|VSTM2A_ENST00000407838.3_Silent_p.A38A			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	38	Ig-like V-type.					extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			ACGTGACGGCGACCGAGGGGC	0.577000													17	55					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567106	45567106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:45567106C>T	ENST00000588982.1	-	3	874	c.373G>A	c.(373-375)Gag>Aag	p.E125K	ZBTB7C_ENST00000586438.1_Missense_Mutation_p.E125K|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.E125K|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.E125K|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.E125K			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	125	Glu-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						TCCATGATCTCCAGGCACACG	0.592000													4	33					0	0	1	0	0
TUBG1	7283	broad.mit.edu	37	17	40762196	40762196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40762196C>T	ENST00000251413.3	+	2	182	c.120C>T	c.(118-120)ttC>ttT	p.F40F	FAM134C_ENST00000585894.1_Intron	NM_001070.4	NP_001061.2	P23258	TBG1_HUMAN	tubulin, gamma 1	40					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TGGAGGAGTTCGCCACCGAGG	0.657000													45	76					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176210	57176210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57176210G>A	ENST00000537055.2	-	2	588	c.357C>T	c.(355-357)ttC>ttT	p.F119F		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						AACAGTAGCTGAAGGCCTTCC	0.632000													12	123					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151085969	151085969	+	Silent	SNP	G	G	A	rs146195573		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151085969G>A	ENST00000474524.1	+	23	3413	c.3375G>A	c.(3373-3375)gcG>gcA	p.A1125A	MED12L_ENST00000273432.4_Silent_p.A985A|P2RY12_ENST00000302632.3_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1125					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGCCTGGGGCGAGAATGACAT	0.517000													9	54					0	0	1	0	0
ABO	28	broad.mit.edu	37	9	136131706	136131706	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136131706C>T	ENST00000453660.2	-	0	422							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		AAGTGCTTCTCCGCCGTCTCC	0.692000													24	66					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79028820	79028820	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79028820C>T	ENST00000446378.2	+	2	4263	c.4232C>T	c.(4231-4233)tCa>tTa	p.S1411L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1411						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GATGAACATTCAGTTCTTGCA	0.408000													9	27					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106976817	106976817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106976817G>A	ENST00000369701.3	+	19	2898	c.2671G>A	c.(2671-2673)Gtg>Atg	p.V891M	SORCS3_ENST00000369699.4_Missense_Mutation_p.V177M	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	891	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GATCTTCCAGGTGACAGCCTA	0.532000													27	54					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120288	38120288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38120288C>T	ENST00000406386.3	+	7	1980	c.1725C>T	c.(1723-1725)ccC>ccT	p.P575P	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	575					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GAGACAACCCCAGAACATCCT	0.582000													31	179					0	0	1	0	0
RILP	83547	broad.mit.edu	37	17	1549859	1549859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:1549859G>A	ENST00000301336.6	-	8	1355	c.1083C>T	c.(1081-1083)agC>agT	p.S361S		NM_031430.2	NP_113618.2	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	361					endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(4)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGGGTGCAGGGCTGCTGGTCT	0.592000													58	61					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115574931	115574931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:115574931G>A	ENST00000371900.4	+	5	717	c.629G>A	c.(628-630)gGg>gAg	p.G210E		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	210					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	TATCAGCCAGGGCAGCTTCCC	0.328000													31	30					0	0	1	0	0
SYNM	23336	broad.mit.edu	37	15	99670140	99670140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:99670140C>T	ENST00000336292.6	+	5	1692	c.1572C>T	c.(1570-1572)ttC>ttT	p.F524F	SYNM_ENST00000560674.1_Silent_p.F239F|SYNM_ENST00000328642.7_Silent_p.F524F|SYNM_ENST00000561323.1_3'UTR|RP11-6O2.4_ENST00000566974.1_RNA	NM_145728.2	NP_663780.2	O15061	SYNEM_HUMAN	synemin, intermediate filament protein	525	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(6)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	29						AGAAAATGTTCGATTCTAAAG	0.448000													21	21					0	0	1	0	0
TAB2	23118	broad.mit.edu	37	6	149720247	149720247	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:149720247T>C	ENST00000367456.1	+	7	2443	c.1866T>C	c.(1864-1866)caT>caC	p.H622H	TAB2_ENST00000536230.1_Silent_p.H590H|TAB2_ENST00000286332.5_Silent_p.H622H|TAB2_ENST00000538427.1_Silent_p.H622H			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2	622					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						CAGGACCACATTTTAACCCCA	0.303000													15	22					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663471	34663471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34663471C>T	ENST00000488417.1	+	2	1086	c.966C>T	c.(964-966)tcC>tcT	p.S322S	C1orf94_ENST00000373374.3_Silent_p.S132S	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	132							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AGATCTGTTCCAAGCCCAAGG	0.612000													18	35					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123615708	123615708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:123615708C>T	ENST00000422452.2	-	22	3886	c.3823G>A	c.(3823-3825)Gag>Aag	p.E1275K	TENM1_ENST00000461429.1_5'UTR|TENM1_ENST00000371130.3_Missense_Mutation_p.E1268K	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TCTTTCGTCTCCACAAGAGAT	0.458000													20	72					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23065152	23065152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23065152C>T	ENST00000246006.4	-	1	1825	c.1678G>A	c.(1678-1680)Gag>Aag	p.E560K		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	560					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCTGCAGGCTCCTGGGGGCCA	0.617000													34	69					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681346	100681346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100681346G>A	ENST00000306151.4	+	3	6713	c.6649G>A	c.(6649-6651)Gaa>Aaa	p.E2217K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2217	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAAGGAAGCAC	0.507000													235	563					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871891	51871891	+	Missense_Mutation	SNP	G	G	A	rs141129077		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51871891G>A	ENST00000371497.5	+	2	2781	c.1894G>A	c.(1894-1896)Gat>Aat	p.D632N	TSHZ2_ENST00000329613.6_Missense_Mutation_p.D629N|TSHZ2_ENST00000603338.2_Missense_Mutation_p.D629N	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	632					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CAGTGAGGGCGATTCTTTCCG	0.512000													21	75					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886286	123886286	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123886286C>T	ENST00000320891.4	+	1	5	c.5C>T	c.(4-6)tCc>tTc	p.S2F		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GAAGAAATGTCCAACGCCAGC	0.512000													17	100					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110535020	110535020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110535020G>A	ENST00000378402.5	+	75	12335	c.12231G>A	c.(12229-12231)gtG>gtA	p.V4077V		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	4077					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCATCACGTGGCCTTCGTGT	0.512000										HNSCC(38;0.096)			11	29					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10468807	10468807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10468807G>A	ENST00000382483.3	-	4	3024	c.2801C>T	c.(2800-2802)cCc>cTc	p.P934L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	934					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTGCCCCTGGGGGCCTCCCCC	0.657000													15	39					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82834819	82834819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82834819C>T	ENST00000265077.3	+	8	6562	c.5997C>T	c.(5995-5997)ttC>ttT	p.F1999F	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.F1012F|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1999	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTTCAGCCTTCCCCTGGGAAG	0.512000													22	54					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328049	126328049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126328049C>T	ENST00000394329.3	+	3	5335	c.5322C>T	c.(5320-5322)ctC>ctT	p.L1774L	FAT4_ENST00000335110.5_Silent_p.L72L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1774	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAAATGCTCTCGTCACATACA	0.433000													31	104					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724711	49724711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49724711C>T	ENST00000551245.1	+	13	2194	c.2083C>T	c.(2083-2085)Cca>Tca	p.P695S	TROAP_ENST00000257909.3_Missense_Mutation_p.P695S|TROAP_ENST00000547923.1_Missense_Mutation_p.P374S			Q12815	TROAP_HUMAN	trophinin associated protein	695					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						TTTGAGACCCCCAGCAGGCCA	0.607000													44	163					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60230367	60230367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:60230367C>T	ENST00000269499.5	+	9	2094	c.1676C>T	c.(1675-1677)tCg>tTg	p.S559L	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.S238L	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	559					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						TGTGTGACCTCGGCTGACCAG	0.428000													23	76					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6634900	6634900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6634900G>A	ENST00000333172.6	+	3	901	c.708G>A	c.(706-708)ggG>ggA	p.G236G	TAS1R1_ENST00000351136.3_Intron|TAS1R1_ENST00000328191.4_Silent_p.G236G	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	236					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTCAGGGGATCTGCATTG	0.622000													34	55					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35802590	35802590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35802590C>T	ENST00000342694.2	+	11	2056	c.1801C>T	c.(1801-1803)Cgt>Tgt	p.R601C		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	601	Protein kinase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ATACTGTCCTCGTGGGAGTTT	0.488000													22	65					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28465784	28465784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28465784G>A	ENST00000261609.7	-	37	5767	c.5659C>T	c.(5659-5661)Cct>Tct	p.P1887S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1887	MIB/HERC2.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CCTGGAGGAGGCCCATCCTGA	0.582000													34	90					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129251120	129251120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129251120C>T	ENST00000296271.3	+	3	651	c.557C>T	c.(556-558)tCg>tTg	p.S186L		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	186			S -> P (in RP4).		protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	CTGCAGTGCTCGTGTGGAATC	0.572000													23	62					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33141495	33141495	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33141495C>T	ENST00000341947.2	-	35	2838	c.2611G>A	c.(2611-2613)Ggg>Agg	p.G871R	COL11A2_ENST00000357486.1_Missense_Mutation_p.G850R|COL11A2_ENST00000361917.1_Missense_Mutation_p.G764R|COL11A2_ENST00000374708.4_Missense_Mutation_p.G785R|COL11A2_ENST00000395197.1_Missense_Mutation_p.G811R|COL11A2_ENST00000374712.1_Missense_Mutation_p.G790R|COL11A2_ENST00000374713.1_Missense_Mutation_p.G824R|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374714.1_Missense_Mutation_p.G845R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	871	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCAGGGGGCCCATGGGGGCCA	0.627000													10	19					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175833	140175833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140175833G>A	ENST00000526136.1	+	1	1284	c.1284G>A	c.(1282-1284)cgG>cgA	p.R428R	PCDHA2_ENST00000378132.1_Silent_p.R428R|PCDHA2_ENST00000520672.2_Silent_p.R428R|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACCGCACGGGACGGGGGCT	0.632000													70	124					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64825409	64825409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64825409C>T	ENST00000358658.3	-	3	445	c.418G>A	c.(418-420)Gag>Aag	p.E140K	NAALADL1_ENST00000339885.2_Missense_Mutation_p.E140K|NAALADL1_ENST00000356632.3_Missense_Mutation_p.E140K|NAALADL1_ENST00000340252.4_Missense_Mutation_p.E140K|NAALADL1_ENST00000355721.3_Missense_Mutation_p.E140K|NAALADL1_ENST00000355369.2_Missense_Mutation_p.E140K	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	140					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CCCCCTTGCTCCCCGGTCACG	0.647000													37	83					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176314494	176314494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176314494G>A	ENST00000292432.5	-	11	1649	c.1558C>T	c.(1558-1560)Cgc>Tgc	p.R520C		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	520	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCAGCATGCGAAGGGAGGAG	0.652000													16	29					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85399759	85399759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85399759G>A	ENST00000258888.5	+	6	2563	c.2396G>A	c.(2395-2397)aGa>aAa	p.R799K		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	799					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GAGGATGGGAGAACATCTGCT	0.517000													47	76					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49688217	49688217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49688217C>T	ENST00000296452.4	+	4	1805	c.1691C>T	c.(1690-1692)cCt>cTt	p.P564L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	564					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTGGGCCAGCCTTCAGGCCCC	0.687000													28	208					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8601135	8601135	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8601135C>T	ENST00000338257.8	-	19	2311		c.e19+1			NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF							unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						AACACACTCACCGACTCTGGG	0.567000													16	102					0	0	1	0	0
MAOA	4128	broad.mit.edu	37	X	43571967	43571967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:43571967C>T	ENST00000338702.3	+	5	550	c.427C>T	c.(427-429)Ccc>Tcc	p.P143S	MAOA_ENST00000497485.1_3'UTR|MAOA_ENST00000542639.1_Missense_Mutation_p.P10S	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	143					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	AACTGATGCACCCTGGGAGGC	0.453000													17	13					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27801613	27801613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27801613G>A	ENST00000408964.2	+	1	2225	c.2174G>A	c.(2173-2175)gGg>gAg	p.G725E		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	725										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					TTACAAGTAGGGACTGACTTC	0.428000													37	88					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82595399	82595399	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82595399G>A	ENST00000423517.2	-	4	4042	c.3705C>T	c.(3703-3705)ctC>ctT	p.L1235L	PCLO_ENST00000333891.8_Silent_p.L1235L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1174					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTCTTCTAGGAGTGGCTTTT	0.388000													94	281					0	0	1	0	0
TAF1A	9015	broad.mit.edu	37	1	222737456	222737456	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:222737456C>T	ENST00000350027.4	-	8	1059	c.906G>A	c.(904-906)caG>caA	p.Q302Q	TAF1A_ENST00000352967.4_Silent_p.Q302Q|TAF1A_ENST00000366890.1_Silent_p.Q188Q|TAF1A_ENST00000391882.1_Silent_p.Q188Q	NM_001201536.1	NP_001188465.1	Q15573	TAF1A_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	302					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding			kidney(3)|large_intestine(3)|lung(11)|urinary_tract(1)	18				GBM - Glioblastoma multiforme(131;0.0186)		ATGGTACAATCTGATACAAAA	0.279000													29	79					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22155533	22155533	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22155533T>C	ENST00000397126.4	-	4	2451	c.2303A>G	c.(2302-2304)aAg>aGg	p.K768R	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATGAATTTTCTTATGATAACT	0.353000													16	59					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104031898	104031898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104031898G>A	ENST00000388887.2	+	8	1018	c.814G>A	c.(814-816)Ggc>Agc	p.G272S		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	272	EGF-like 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CCGTGGGGATGGCCAAGTGTG	0.498000													39	67					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669801	158669801	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158669801G>A	ENST00000359610.2	-	1	685	c.642C>T	c.(640-642)ctC>ctT	p.L214L		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					ACATGAAGATGAGCATCACAG	0.493000													46	80					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139727187	139727187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139727187G>A	ENST00000263549.3	-	10	2390	c.1517C>T	c.(1516-1518)tCc>tTc	p.S506F		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	506	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					CTCTTCCGAGGAAGAACTAAG	0.448000													43	100					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100933186	100933186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100933186G>A	ENST00000325455.5	-	4	3657	c.2204C>T	c.(2203-2205)tCa>tTa	p.S735L	PGR_ENST00000534013.1_Missense_Mutation_p.S141L|PGR_ENST00000263463.5_Intron	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	735	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	ACCTGGCAATGATTTAGACCA	0.328000													28	112					0	0	1	0	0
RHOT1	55288	broad.mit.edu	37	17	30526555	30526555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:30526555C>T	ENST00000358365.3	+	13	1313	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F	RHOT1_ENST00000581094.1_Silent_p.F362F|RHOT1_ENST00000354266.3_Silent_p.F341F|RHOT1_ENST00000333942.6_Silent_p.F362F|RHOT1_ENST00000394692.2_Silent_p.F362F|RHOT1_ENST00000545287.2_Silent_p.F362F|RHOT1_ENST00000583994.1_Silent_p.F235F	NM_001033568.1	NP_001028740.1	Q8IXI2	MIRO1_HUMAN	ras homolog family member T1	362					apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			NS(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				ACCAGGGATTCCTTTCCCAGT	0.378000													29	42					0	0	1	0	0
FKRP	79147	broad.mit.edu	37	19	47258815	47258815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47258815C>T	ENST00000318584.5	+	4	405	c.108C>T	c.(106-108)gcC>gcT	p.A36A	FKRP_ENST00000391909.3_Silent_p.A36A|FKRP_ENST00000600646.1_Intron	NM_001039885.2|NM_024301.4	NP_001034974.1|NP_077277.1	Q9H9S5	FKRP_HUMAN	fukutin related protein	36						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			NS(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		ATTCCCGGGCCCGGGGGCCCC	0.677000													3	16					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	271138	271138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:271138C>T	ENST00000538872.1	+	8	2608	c.2490C>T	c.(2488-2490)atC>atT	p.I830I	IQSEC3_ENST00000382841.2_Silent_p.I527I|IQSEC3_ENST00000326261.4_Silent_p.I830I			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	830	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TGGTAGGCATCTATGAGAGGA	0.577000													5	18					0	0	1	0	0
HIBADH	11112	broad.mit.edu	37	7	27582693	27582693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27582693G>A	ENST00000265395.2	-	5	717	c.511C>T	c.(511-513)Ctc>Ttc	p.L171F		NM_152740.3	NP_689953.1	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase	171					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(4)|kidney(2)|lung(3)|ovary(2)|prostate(1)	12			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	ATAAACGTGAGGTTCCCAGAT	0.458000													24	42					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139192923	139192923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139192923G>A	ENST00000274710.3	+	3	606	c.401G>A	c.(400-402)cGg>cAg	p.R134Q		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	134					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGATGTGCGGGATGGCTTC	0.612000													25	99					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85438259	85438259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85438259C>T	ENST00000394573.1	+	6	568	c.366C>T	c.(364-366)ttC>ttT	p.F122F	SLC28A1_ENST00000286749.3_Silent_p.F122F|SLC28A1_ENST00000538177.1_Silent_p.F122F|SLC28A1_ENST00000537624.1_Silent_p.F122F|SLC28A1_ENST00000338602.2_Silent_p.F122F|SLC28A1_ENST00000537216.1_Silent_p.F122F|SLC28A1_ENST00000537703.1_Silent_p.F44F	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	122					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCCTCACCTTCCTGGGCCACC	0.622000													10	167					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38320156	38320156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38320156C>T	ENST00000264645.7	+	7	1434	c.1208C>T	c.(1207-1209)tCc>tTc	p.S403F		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	403	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						GAGAAGAAATCCTATTCCCGG	0.567000													19	119					0	0	1	0	0
C9orf139	401563	broad.mit.edu	37	9	139929438	139929438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139929438G>A	ENST00000314330.2	+	3	2019	c.505G>A	c.(505-507)Ggg>Agg	p.G169R		NM_207511.1	NP_997394.1	Q6ZV77	CI139_HUMAN	chromosome 9 open reading frame 139	169										cervix(1)|lung(2)	3	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		GGAAAGAAAAGGGCATGAGTC	0.622000													13	114					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132177606	132177606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:132177606G>A	ENST00000374786.1	+	4	1029	c.550G>A	c.(550-552)Gaa>Aaa	p.E184K	NTM_ENST00000374791.3_Missense_Mutation_p.E184K|NTM_ENST00000539799.1_Missense_Mutation_p.E184K|NTM_ENST00000427481.2_Missense_Mutation_p.E175K|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000374784.1_Missense_Mutation_p.E184K|NTM_ENST00000425719.2_Missense_Mutation_p.E184K	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	184	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane		p.E184K(2)|p.E184*(2)		breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						GAGTGAAGACGAATACTTGGA	0.493000													23	59					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99441317	99441317	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:99441317C>T	ENST00000287042.4	+	2	1460	c.1110C>T	c.(1108-1110)gtC>gtT	p.V370V	KCNS2_ENST00000521839.1_Silent_p.V370V	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	370						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GGGCTACCGTCAGTATGACCA	0.617000													23	51					0	0	1	0	0
CHST12	55501	broad.mit.edu	37	7	2473276	2473276	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2473276C>T	ENST00000258711.6	+	2	1137	c.1002C>T	c.(1000-1002)atC>atT	p.I334I		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	334					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CGTGCCAGATCGACTACGACT	0.657000													7	58					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101710325	101710325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:101710325G>A	ENST00000251127.6	-	43	5070	c.4989C>T	c.(4987-4989)ccC>ccT	p.P1663P	NALCN-AS1_ENST00000457843.1_RNA	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1663						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATTTCCTCTGGGGTTTCCCTG	0.562000													18	62					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32010529	32010529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:32010529G>A	ENST00000438447.1	+	6	1736	c.1348G>A	c.(1348-1350)Gaa>Aaa	p.E450K	PDZD2_ENST00000282493.3_Missense_Mutation_p.E450K			O15018	PDZD2_HUMAN	PDZ domain containing 2	450					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GACTGATAACGAAGACCAGGA	0.522000													18	91					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714363	70714363	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70714363C>T	ENST00000530196.1	-	0	155					NR_003951.1																						ACACTAGGGTCCCATCCACTG	0.527000													50	103					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134990687	134990687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:134990687G>A	ENST00000535938.1	+	12	1519	c.1352G>A	c.(1351-1353)cGa>cAa	p.R451Q	SAGE1_ENST00000370709.3_Missense_Mutation_p.R451Q|SAGE1_ENST00000537770.1_Intron|SAGE1_ENST00000324447.3_Missense_Mutation_p.R451Q	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	451								p.R451Q(1)		breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					AATGGCCAACGAAAACAGGAT	0.428000													77	70					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	124097438	124097438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:124097438C>T	ENST00000422452.2	-	1	228	c.165G>A	c.(163-165)atG>atA	p.M55I	TENM1_ENST00000371130.3_Missense_Mutation_p.M55I	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TATTGTAATTCATCCTCAGCT	0.373000													106	82					0	0	1	0	0
VPS45	11311	broad.mit.edu	37	1	150065671	150065671	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150065671C>T	ENST00000369130.3	+	13	1966	c.1420C>T	c.(1420-1422)Ctg>Ttg	p.L474L	VPS45_ENST00000535106.1_Silent_p.L405L|VPS45_ENST00000369128.5_Silent_p.L369L	NM_007259.3	NP_009190.2	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45 homolog (S. cerevisiae)	474					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACATGAAACCCTGGATCATCT	0.373000													43	89					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38319978	38319978	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38319978A>T	ENST00000264645.7	+	7	1256	c.1030A>T	c.(1030-1032)Aag>Tag	p.K344*		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	344					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						TGAGACTGTTAAGCATGAGAT	0.547000													85	90					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77286708	77286708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77286708G>A	ENST00000376896.2	+	9	1727	c.1115G>A	c.(1114-1116)cGa>cAa	p.R372Q	RORB_ENST00000396204.2_Missense_Mutation_p.R383Q	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	383	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						TCATCAGACCGAGCCTGGCTT	0.408000													18	52					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85985238	85985238	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85985238G>T	ENST00000372113.4	-	1	44	c.39C>A	c.(37-39)gtC>gtA	p.V13V	LRIT2_ENST00000538192.1_Silent_p.V13V	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	13						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						TATCCAGAAAGACCAGAACTA	0.478000													13	34					3.27435e-08	3.28506e-08	1	1	0
PIWIL3	440822	broad.mit.edu	37	22	25145731	25145731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25145731C>T	ENST00000332271.5	-	10	1561	c.1145G>A	c.(1144-1146)aGa>aAa	p.R382K	PIWIL3_ENST00000533313.1_Missense_Mutation_p.R273K|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.R273K	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	382	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CTTTTTCCATCTGCCCTGGCT	0.463000													20	58					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101117834	101117834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:101117834G>A	ENST00000394095.2	-	6	601	c.548C>T	c.(547-549)cCa>cTa	p.P183L	SENP7_ENST00000358203.3_Intron|SENP7_ENST00000314261.7_Missense_Mutation_p.P117L|SENP7_ENST00000348610.3_Missense_Mutation_p.P150L|SENP7_ENST00000394091.1_Intron|SENP7_ENST00000394094.2_Intron	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	183					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AGTTACAGGTGGGGTCCTTAT	0.403000													33	75					0	0	1	0	0
GPAT2	150763	broad.mit.edu	37	2	96691678	96691678	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96691678C>T	ENST00000434632.1	-	13	1697	c.1238_splice	c.e13+1	p.C413_splice	GPAT2_ENST00000359548.4_Splice_Site_p.C413_splice|GPAT2_ENST00000377137.3_Splice_Site_p.C413_splice|GPAT2_ENST00000453542.1_Splice_Site_p.C342_splice			Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2, mitochondrial	413					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(5)|skin(3)	16						GTGCCCCTACCATTGGCCCAG	0.607000													20	48					0	0	1	0	0
TCAIM	285343	broad.mit.edu	37	3	44402978	44402978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44402978C>T	ENST00000342649.4	+	4	714	c.287C>T	c.(286-288)tCc>tTc	p.S96F	TCAIM_ENST00000417237.1_Missense_Mutation_p.S96F	NM_173826.3	NP_776187.2			T cell activation inhibitor, mitochondrial																		GACCAGAGTTCCTCCGATGGC	0.383000													11	76					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671604	39671604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39671604C>T	ENST00000398930.1	+	4	775	c.421C>T	c.(421-423)Cat>Tat	p.H141Y	KCNJ15_ENST00000328656.3_Missense_Mutation_p.H141Y|KCNJ15_ENST00000398934.1_Missense_Mutation_p.H141Y|KCNJ15_ENST00000398932.1_Missense_Mutation_p.H141Y|KCNJ15_ENST00000398938.2_Missense_Mutation_p.H141Y			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	141					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						GGAATGTCCTCATGCCATCTT	0.502000													30	86					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113348734	113348734	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113348734C>T	ENST00000458497.1	+	9	987	c.708C>T	c.(706-708)tcC>tcT	p.S236S	ALPK1_ENST00000177648.9_Silent_p.S236S|ALPK1_ENST00000504176.2_Silent_p.S158S	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	236							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AGGGCCTCTCCACGTCGCTAG	0.383000													6	69					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230928655	230928655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230928655G>A	ENST00000354537.1	+	16	1855	c.1773G>A	c.(1771-1773)cgG>cgA	p.R591R	CAPN9_ENST00000480004.1_3'UTR|CAPN9_ENST00000366666.2_Silent_p.R554R|CAPN9_ENST00000271971.2_Silent_p.R617R|RP11-99J16__A.2_ENST00000452640.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA|RP11-99J16__A.2_ENST00000428480.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	617	Domain IV.|EF-hand 2.|EF-hand 3.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				ATGAACTACGGACTGCACTGA	0.527000													64	115					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38990708	38990708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:38990708C>T	ENST00000318792.1	+	2	512	c.502C>T	c.(502-504)Cct>Tct	p.P168S		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	168										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		CCTCTCAGATCCTCTGGGGGT	0.527000													12	13					0	0	1	0	0
MYL10	93408	broad.mit.edu	37	7	101256771	101256771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101256771C>T	ENST00000223167.4	-	8	842	c.665G>A	c.(664-666)gGt>gAt	p.G222D		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	222	EF-hand 3.					mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						CTTCTCTTCACCGTGAGTGAT	0.547000													14	91					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074624	106074624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106074624G>A	ENST00000278071.2	-	3	1638	c.1186C>T	c.(1186-1188)Cta>Tta	p.L396L	ITPRIP_ENST00000358187.2_Silent_p.L396L|ITPRIP_ENST00000337478.1_Silent_p.L396L	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	396						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						AGTGCCTTTAGTGTCGTCCTG	0.642000													16	63					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210557911	210557911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:210557911C>T	ENST00000360351.4	+	7	1523	c.1017C>T	c.(1015-1017)ccC>ccT	p.P339P	MAP2_ENST00000447185.1_Silent_p.P335P|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000392194.1_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	339					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AAACATCGCCCTTTGCCCCTG	0.438000													30	81					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717552	13717552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13717552C>T	ENST00000279593.3	-	13	2829	c.2620G>A	c.(2620-2622)Ggg>Agg	p.G874R		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	874					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATCGCCACCCCATGGATGCAG	0.527000													37	114					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112018759	112018759	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112018759C>T	ENST00000374566.3	-	8	1271	c.752_splice	c.e8-1	p.G252_splice	EPB41L4B_ENST00000374557.4_Splice_Site_p.G252_splice	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	252	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGGCTCTTTCCCCTTAGAAAA	0.473000													18	76					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92459677	92459677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:92459677C>T	ENST00000318445.6	+	2	849	c.635C>T	c.(634-636)tCg>tTg	p.S212L	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.S212L	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	212					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			AAGGACTCCTCGCTCTATATA	0.587000													3	22					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69387775	69387775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:69387775G>A	ENST00000193403.6	-	3	671	c.288C>T	c.(286-288)gcC>gcT	p.A96A	ACTN1_ENST00000438964.2_Silent_p.A96A|ACTN1_ENST00000376839.3_Silent_p.A31A|ACTN1_ENST00000538545.2_Silent_p.A96A|ACTN1_ENST00000394419.4_Silent_p.A96A	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	96	Actin-binding.|CH 1.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TGAAATCCAGGGCCTTGTTGA	0.547000													30	100					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10697863	10697863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:10697863C>T	ENST00000302079.6	-	41	6370	c.6371G>A	c.(6370-6372)cGa>cAa	p.R2124Q	PIEZO2_ENST00000538948.1_Missense_Mutation_p.R81Q|PIEZO2_ENST00000285141.4_5'UTR|PIEZO2_ENST00000580640.1_Missense_Mutation_p.R2149Q|PIEZO2_ENST00000503781.3_Missense_Mutation_p.R2124Q			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2124	Ser-rich.					integral to membrane	ion channel activity										ACTGCTGTTTCGGGTGCTTGT	0.403000													4	33					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004741	52004741	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52004741G>A	ENST00000291707.3	-	1	302	c.247C>T	c.(247-249)Cga>Tga	p.R83*		NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	83	Ig-like V-type 1.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGCACTGCTCGAGCTGGGTTG	0.572000													47	128					0	0	1	0	0
MIR329-1	574408	broad.mit.edu	37	14	101493187	101493187	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101493187C>T	ENST00000385028.1	+	0	66					NR_029967.1																						CCTGGTTAACCTCTTTTCCAG	0.463000													52	118					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49700328	49700328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49700328G>A	ENST00000296452.4	+	7	10851	c.10737G>A	c.(10735-10737)gaG>gaA	p.E3579E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3579					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TGGGCCAGGAGGAGACGGACT	0.612000													25	75					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38935268	38935268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38935268C>T	ENST00000355481.4	+	7	713	c.582C>T	c.(580-582)ttC>ttT	p.F194F	RYR1_ENST00000360985.3_Silent_p.F194F|RYR1_ENST00000359596.3_Silent_p.F194F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	194	MIR 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACGCTTCCTTCATGCAGACAC	0.622000													10	19					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129663406	129663406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129663406G>A	ENST00000358303.4	-	8	1262	c.1178C>T	c.(1177-1179)cCa>cTa	p.P393L	ZC3HC1_ENST00000360708.5_Intron|RP11-306G20.1_ENST00000480018.1_RNA|ZC3HC1_ENST00000481503.1_Missense_Mutation_p.P350L|ZC3HC1_ENST00000311873.5_Missense_Mutation_p.P372L|RP11-306G20.1_ENST00000587038.1_RNA	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	393					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					AGGGCTAGATGGTACCTCCAG	0.607000													47	116					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116224391	116224391	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116224391A>G	ENST00000374140.2	+	4	534	c.325A>G	c.(325-327)Agc>Ggc	p.S109G	RGS3_ENST00000350696.5_Missense_Mutation_p.S109G	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	109					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GGAGTGGCTAAGCCCTGATAT	0.557000													11	109					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104898241	104898241	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:104898241G>A	ENST00000507740.1	+	2	1074	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K	RIMS2_ENST00000406091.3_Missense_Mutation_p.E472K|RIMS2_ENST00000262231.10_Missense_Mutation_p.E280K|RIMS2_ENST00000436393.2_Missense_Mutation_p.E250K	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	503					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AACAAAACGGGAAAAAATGGA	0.448000										HNSCC(12;0.0054)			14	45					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40030130	40030130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40030130G>A	ENST00000372856.3	-	10	2217	c.1418C>T	c.(1417-1419)gCc>gTc	p.A473V	PABPC4_ENST00000372857.3_Intron|PABPC4_ENST00000372858.3_Missense_Mutation_p.A473V|PABPC4_ENST00000372862.3_Intron	NM_001135654.1	NP_001129126.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	486					blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCCACGAGAGGCCGGAGCATT	0.562000													49	120					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122853693	122853693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122853693C>T	ENST00000264811.5	-	1	919	c.501G>A	c.(499-501)gcG>gcA	p.A167A	TRPC3_ENST00000513531.1_Silent_p.A167A|TRPC3_ENST00000379645.3_Silent_p.A240A	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	155					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GGCAGTGCGCCGCCAGGATGA	0.617000													15	65					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188164	140188164	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140188164G>A	ENST00000530339.1	+	1	1392	c.1392G>A	c.(1390-1392)gtG>gtA	p.V464V	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.V464V|PCDHA4_ENST00000512229.2_Silent_p.V464V|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGTTCGTGAAGGAGAACA	0.642000													36	72					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456549	5456549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5456549C>T	ENST00000222033.4	+	1	1124	c.1047C>T	c.(1045-1047)ccC>ccT	p.P349P		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	349						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GCTCCTGCCCCGTGTGCAAAC	0.642000													13	119					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377318	55377318	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55377318C>T	ENST00000326321.3	+	7	1092	c.1059C>T	c.(1057-1059)atC>atT	p.I353I	KIR3DL1_ENST00000402254.2_Silent_p.I353I|KIR3DL2_ENST00000270442.5_Silent_p.I336I	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	353					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		tcctcttcatcctcctcctct	0.498000													24	58					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179306689	179306689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179306689G>A	ENST00000356834.3	-	8	1392	c.1355C>T	c.(1354-1356)tCc>tTc	p.S452F	TBC1D9B_ENST00000355235.3_Missense_Mutation_p.S452F	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	452						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGGCCCTGGGATGCGGTTGG	0.672000													49	97					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61597340	61597340	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61597340G>A	ENST00000238508.3	+	6	611	c.552G>A	c.(550-552)gtG>gtA	p.V184V		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				TGATTCTGGTGAACGCCCTAT	0.388000													7	91					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818577	159818577	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159818577G>A	ENST00000497452.1	-	0	517																											GGCCCGGACCGGAAGCGGCGC	0.776000													7	23					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	107823108	107823108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:107823108C>T	ENST00000375915.2	-	3	1252	c.1114G>A	c.(1114-1116)Gat>Aat	p.D372N		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	372						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						TCTGGTTCATCATTGGTTAGA	0.443000													16	43					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78444657	78444657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:78444657G>A	ENST00000370767.1	-	1	119	c.32C>T	c.(31-33)tCt>tTt	p.S11F	FUBP1_ENST00000436586.2_Missense_Mutation_p.S11F|FUBP1_ENST00000370768.2_Missense_Mutation_p.S11F			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	11					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						TGAGCCAGAAGAGGGGGGAGG	0.562000			"""F, N"""		oligodendroglioma								16	37					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42607562	42607562	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42607562G>A	ENST00000359486.3	-	1	3886	c.3750C>T	c.(3748-3750)ccC>ccT	p.P1250P	TCF20_ENST00000335626.4_Silent_p.P1250P	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						TCATGATTAAGGGGTTTTGAG	0.463000													6	96					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059153	152059153	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152059153T>C	ENST00000368806.1	-	3	1069	c.1005A>G	c.(1003-1005)gaA>gaG	p.E335E		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	335							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CCTTTCCTGGTTCTTGAGTGT	0.448000													79	310					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55284800	55284800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55284800C>T	ENST00000336077.6	+	3	126	c.86C>T	c.(85-87)cCt>cTt	p.P29L	KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL1_ENST00000291633.7_Missense_Mutation_p.P29L|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	29					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		CACAGAAAACCTTCCCTCCTG	0.507000													13	121					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44151644	44151644	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44151644C>T	ENST00000223357.3	+	16	2337	c.2032C>T	c.(2032-2034)Cag>Tag	p.Q678*	AEBP1_ENST00000450684.2_Nonsense_Mutation_p.Q253*	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	678	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						GGTGGCAGCGCAGATGGTGGG	0.657000													16	28					0	0	1	0	0
MAP7	9053	broad.mit.edu	37	6	136709639	136709639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136709639C>T	ENST00000354570.3	-	5	828	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	MAP7_ENST00000438100.2_Missense_Mutation_p.E162K|MAP7_ENST00000454590.1_Missense_Mutation_p.E162K|MAP7_ENST00000544465.1_Missense_Mutation_p.E125K|MAP7_ENST00000432797.2_5'UTR	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	140					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		ACAACAGCTTCGTGGCGTTCC	0.493000													33	66					0	0	1	0	0
A4GALT	53947	broad.mit.edu	37	22	43089247	43089247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43089247G>A	ENST00000401850.1	-	2	1200	c.711C>T	c.(709-711)ttC>ttT	p.F237F	A4GALT_ENST00000381278.3_Silent_p.F237F|A4GALT_ENST00000249005.2_Silent_p.F237F			Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	237					glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			NS(1)|central_nervous_system(2)|large_intestine(6)|skin(1)|urinary_tract(1)	11						AGTGGTCCACGAAGTCCCGCA	0.657000													7	23					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113544905	113544905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113544905C>T	ENST00000546530.1	-	16	1942	c.1657G>A	c.(1657-1659)Gaa>Aaa	p.E553K	RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000261729.5_Missense_Mutation_p.E552K|RASAL1_ENST00000446861.3_Missense_Mutation_p.E552K|RASAL1_ENST00000548055.1_Missense_Mutation_p.E552K	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	551					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						AACTCACCTTCATCCCCATCC	0.597000													23	54					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55224310	55224310	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55224310C>T	ENST00000275493.2	+	9	1268	c.1091C>T	c.(1090-1092)tCc>tTc	p.S364F	EGFR_ENST00000344576.2_Missense_Mutation_p.S364F|EGFR_ENST00000420316.2_Missense_Mutation_p.S364F|EGFR_ENST00000454757.2_Missense_Mutation_p.S311F|EGFR_ENST00000442591.1_Missense_Mutation_p.S364F|EGFR_ENST00000342916.3_Missense_Mutation_p.S364F|EGFR_ENST00000455089.1_Missense_Mutation_p.S319F	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	364					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AACTGCACCTCCATCAGTGGC	0.413000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			17	83					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537102	5537102	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5537102G>A	ENST00000380184.1	-	1	833	c.570C>T	c.(568-570)ttC>ttT	p.F190F	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	190										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		ACTGCCACATGAACTCCATGT	0.473000													66	105					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54610467	54610467	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:54610467C>T	ENST00000302287.3	+	1	450	c.44C>T	c.(43-45)tCc>tTc	p.S15F	VSTM2A_ENST00000402613.3_Missense_Mutation_p.S15F|VSTM2A_ENST00000402026.2_Missense_Mutation_p.S14F|VSTM2A_ENST00000404951.1_Missense_Mutation_p.S15F|VSTM2A_ENST00000407838.3_Missense_Mutation_p.S15F			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	15						extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			GTTTTCTTTTCCGTTTTATAT	0.413000													48	101					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106322213	106322213	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106322213G>A	ENST00000390559.2	-	0	110																											AGAAAGTGATGGAGTCGGGAA	0.597000													5	21					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632215	122632215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122632215C>T	ENST00000195173.4	-	17	2637	c.2334G>A	c.(2332-2334)tgG>tgA	p.W778*	SEMA5B_ENST00000357599.3_Nonsense_Mutation_p.W779*|SEMA5B_ENST00000451055.2_Nonsense_Mutation_p.W833*			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	779					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GCCACGGCGTCCAGGGGGTGT	0.716000													4	9					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66112422	66112422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:66112422G>A	ENST00000503581.1	-	7	1670	c.1133C>T	c.(1132-1134)cCt>cTt	p.P378L	EYS_ENST00000393380.2_Missense_Mutation_p.P378L|EYS_ENST00000370616.2_Missense_Mutation_p.P378L|EYS_ENST00000370618.3_Missense_Mutation_p.P378L|EYS_ENST00000370621.3_Missense_Mutation_p.P378L|EYS_ENST00000342421.5_Missense_Mutation_p.P378L	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	378	EGF-like 5.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						ATTCCTCAAAGGAAATGACTC	0.279000													13	95					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57089547	57089547	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57089547C>T	ENST00000330619.8	+	6	2436	c.1750C>T	c.(1750-1752)Cag>Tag	p.Q584*	ZNF470_ENST00000391709.3_Nonsense_Mutation_p.Q584*|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	584				Q -> P (in Ref. 1; AAS64219).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TGTTCAACATCAGAGACTCCA	0.453000													34	104					0	0	1	0	0
HK1	3098	broad.mit.edu	37	10	71103627	71103627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71103627C>T	ENST00000448642.2	+	7	602	c.213C>T	c.(211-213)ctC>ctT	p.L71L	HK1_ENST00000494253.1_3'UTR|HK1_ENST00000360289.2_Silent_p.L24L|HK1_ENST00000404387.2_Silent_p.L40L|HK1_ENST00000359426.6_Silent_p.L36L|HK1_ENST00000298649.3_Silent_p.L35L			P19367	HXK1_HUMAN	hexokinase 1	36	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						ATGAAACTCTCATAGATATCA	0.502000													58	141					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119750052	119750052	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:119750052G>A	ENST00000541757.1	+	16	1398	c.1018_splice	c.e16+1	p.G340_splice	MARCO_ENST00000327097.4_Splice_Site_p.G418_splice			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	418	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGGTGAAAGAGGTAATCACTA	0.413000													10	45					0	0	1	0	0
TGIF2	60436	broad.mit.edu	37	20	35219337	35219337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35219337C>T	ENST00000373874.2	+	3	416	c.217C>T	c.(217-219)Cgg>Tgg	p.R73W	TGIF2-C20orf24_ENST00000558530.1_Intron|RP5-977B1.11_ENST00000561134.1_RNA|TGIF2_ENST00000373872.4_Missense_Mutation_p.R73W	NM_001199514.1|NM_001199515.1	NP_001186443.1|NP_001186444.1	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	73						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(3)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CATCAATGCCCGGCGGCGGCT	0.522000													41	348					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100118719	100118719	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100118719G>A	ENST00000330710.5	+	2	512	c.414G>A	c.(412-414)ctG>ctA	p.L138L	HHIPL1_ENST00000357223.2_Silent_p.L138L	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	138					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				TCTGGGCGCTGGAGGGCAACC	0.602000													12	58					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25890627	25890627	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:25890627A>T	ENST00000520164.1	-	6	1062	c.525T>A	c.(523-525)acT>acA	p.T175T	EBF2_ENST00000408929.3_Silent_p.T27T	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	175					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GGTCCGATGGAGTCTCATTTC	0.388000													7	119					0	0	1	0	0
DPRX	503834	broad.mit.edu	37	19	54140117	54140117	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54140117C>T	ENST00000376650.1	+	3	502	c.451C>T	c.(451-453)Cat>Tat	p.H151Y		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	151						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		CAGAATAGTCCATTTTGGCTG	0.522000													61	135					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099726	168099726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168099726C>T	ENST00000409195.1	+	9	1913	c.1824C>T	c.(1822-1824)atC>atT	p.I608I	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Silent_p.I608I|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.I386I	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	433					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATCAAGAAATCATTGCTGGTG	0.423000													26	82					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230008	21230008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21230008C>T	ENST00000233242.1	-	26	9859	c.9732G>A	c.(9730-9732)agG>agA	p.R3244R		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3244					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTGAAAGGTCCTGGGGAGCT	0.393000													15	49					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167786823	167786823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:167786823G>A	ENST00000397829.4	-	8	982	c.815C>T	c.(814-816)tCc>tTc	p.S272F	TCP10_ENST00000366827.2_Intron	NM_004610.3	NP_004601.3	Q12799	TCP10_HUMAN	t-complex 10	299						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		TATTTCCAGGGAAGATGGTGG	0.488000													6	88					0	0	1	0	0
SRC	6714	broad.mit.edu	37	20	36030030	36030030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36030030G>A	ENST00000373578.2	+	11	1414	c.1065G>A	c.(1063-1065)ggG>ggA	p.G355G	SRC_ENST00000373567.2_Silent_p.G355G|SRC_ENST00000360723.4_Silent_p.G361G|SRC_ENST00000477066.1_3'UTR|SRC_ENST00000373558.2_Silent_p.G361G|SRC_ENST00000358208.4_Silent_p.G355G|SRC_ENST00000445403.1_Silent_p.G355G	NM_198291.1	NP_938033.1	P12931	SRC_HUMAN	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog	355	Protein kinase.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(16)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	TTCTCAAGGGGGAGACAGGCA	0.622000													21	79					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956173	18956173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18956173G>A	ENST00000302797.3	-	1	383	c.159C>T	c.(157-159)ggC>ggT	p.G53G	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	53					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GCATGCGGCAGCCCAGGAGCC	0.562000													61	140					0	0	1	0	0
MYL10	93408	broad.mit.edu	37	7	101256829	101256829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101256829G>A	ENST00000223167.4	-	8	784	c.607C>T	c.(607-609)Ccc>Tcc	p.P203S		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	203	EF-hand 3.					mitochondrion	calcium ion binding	p.P203S(1)		breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						ACATCTGGGGGAAATGCTGCA	0.557000													33	94					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55027359	55027359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:55027359G>A	ENST00000324000.3	+	4	3028	c.994G>A	c.(994-996)Gaa>Aaa	p.E332K		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	332					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CAACACAAGGGAAGATCTTCC	0.463000													19	57					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130282158	130282158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130282158C>T	ENST00000358511.6	+	2	342	c.311C>T	c.(310-312)tCc>tTc	p.S104F	COL6A6_ENST00000453409.2_Missense_Mutation_p.S104F	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	104	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ATTGGCGGGTCCCTGCAGATA	0.493000													9	39					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54647986	54647986	+	Missense_Mutation	SNP	C	C	T	rs138688054	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54647986C>T	ENST00000406403.1	+	6	2004	c.401C>T	c.(400-402)aCg>aTg	p.T134M	CNOT3_ENST00000221232.5_Missense_Mutation_p.T134M|CNOT3_ENST00000358389.3_5'UTR			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	134					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACCATCGACACGCTCAACATG	0.562000													17	28					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124989840	124989840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124989840G>A	ENST00000522917.1	+	10	1260	c.1054G>A	c.(1054-1056)Gga>Aga	p.G352R	FER1L6_ENST00000399018.1_Missense_Mutation_p.G352R	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	352						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CGAACAGGATGGAGACAAAGG	0.473000													12	25					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289451	107289451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107289451G>A	ENST00000277216.3	-	1	39	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						AGTCCCAGAAGAATGAATTCT	0.398000													10	100					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99631479	99631479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99631479C>T	ENST00000324306.6	+	6	1585	c.1351C>T	c.(1351-1353)Cat>Tat	p.H451Y	ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.H415Y|ZKSCAN1_ENST00000535170.1_Missense_Mutation_p.H238Y	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	451					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TCTCATCCTCCATCAGCGCAT	0.512000													81	202					0	0	1	0	0
GPR27	2850	broad.mit.edu	37	3	71803815	71803815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:71803815C>T	ENST00000304411.2	+	1	615	c.615C>T	c.(613-615)ctC>ctT	p.L205L	EIF4E3_ENST00000421769.2_5'UTR	NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	205						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		TCCGCCTGCTCTTCTTCATCC	0.761000													3	11					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394441	164394441	+	Missense_Mutation	SNP	C	C	T	rs147436359		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164394441C>T	ENST00000280605.3	-	1	606	c.446G>A	c.(445-447)cGg>cAg	p.R149Q		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	149						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GCAGAACACCCGGTAGCTGGC	0.532000													20	85					0	0	1	0	0
APOF	319	broad.mit.edu	37	12	56755842	56755842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56755842G>A	ENST00000398189.3	-	2	225	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S	APOF_ENST00000541105.1_Missense_Mutation_p.P32S	NM_001638.2	NP_001629.1	Q13790	APOF_HUMAN	apolipoprotein F	50					cholesterol metabolic process	high-density lipoprotein particle|low-density lipoprotein particle	cholesterol binding|lipid transporter activity|receptor binding			breast(1)|lung(3)|prostate(1)|stomach(1)	6						AAGGACAAGGGAAAGTGCATC	0.517000													23	118					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15734690	15734690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15734690G>A	ENST00000281171.4	+	23	3540	c.3210G>A	c.(3208-3210)gaG>gaA	p.E1070E	PTPRO_ENST00000542557.1_Silent_p.E231E|PTPRO_ENST00000442921.2_Silent_p.E259E|PTPRO_ENST00000544244.1_Silent_p.E231E|PTPRO_ENST00000348962.2_Silent_p.E1042E|PTPRO_ENST00000445537.2_Silent_p.E259E	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	1070	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TGATTTCAGAGGAAGAGCAGG	0.498000													28	60					0	0	1	0	0
DPP7	29952	broad.mit.edu	37	9	140006426	140006426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140006426G>A	ENST00000371579.2	-	10	1110	c.1106C>T	c.(1105-1107)cCg>cTg	p.P369L		NM_013379.2	NP_037511.2	Q9UHL4	DPP2_HUMAN	dipeptidyl-peptidase 7	369						cytoplasmic membrane-bounded vesicle|extracellular region|lysosome	aminopeptidase activity|protein binding|serine-type peptidase activity			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;4.25e-05)|Epithelial(140;0.000633)		GGGCAGGTCCGGGAACATATC	0.667000													6	40					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32972621	32972621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32972621C>T	ENST00000544455.1	+	27	10198	c.9971C>T	c.(9970-9972)cCa>cTa	p.P3324L	BRCA2_ENST00000380152.3_Missense_Mutation_p.P3324L	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3324					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAGATGACTCCATTTAAAAAA	0.383000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			21	53					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24435081	24435081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24435081G>A	ENST00000330966.7	-	2	208	c.46C>T	c.(46-48)Ccc>Tcc	p.P16S	MYOM3_ENST00000374434.3_Missense_Mutation_p.P16S|MYOM3_ENST00000329601.7_Missense_Mutation_p.P16S			Q5VTT5	MYOM3_HUMAN	myomesin 3	16										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		ATGGCCTGGGGGGGCCGGGGG	0.667000													4	5					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11504555	11504555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11504555G>A	ENST00000379237.1	-	15	2766	c.2372C>T	c.(2371-2373)tCa>tTa	p.S791L	USP6NL_ENST00000277575.5_Missense_Mutation_p.S808L	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	791						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						TGCGGCCGGTGAAGCTTTATA	0.532000													40	138					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577496	14577496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14577496C>T	ENST00000544627.1	+	2	991	c.671C>T	c.(670-672)cCt>cTt	p.P224L	ATF7IP_ENST00000536444.1_Missense_Mutation_p.P216L|ATF7IP_ENST00000543189.1_Missense_Mutation_p.P216L|ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000540793.1_Missense_Mutation_p.P216L|ATF7IP_ENST00000261168.4_Missense_Mutation_p.P216L			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	216					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						GAACCGGTCCCTGTTGAACCC	0.522000													39	115					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2290852	2290852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2290852G>A	ENST00000381458.5	+	3	273	c.210G>A	c.(208-210)acG>acA	p.T70T		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	70					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	CGGCCATGACGAAGGCTGTGT	0.532000													32	149					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157903591	157903591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157903591C>T	ENST00000409483.1	-	9	1577	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K	PTPRN2_ENST00000389413.3_Intron|PTPRN2_ENST00000389416.4_Missense_Mutation_p.E508K|PTPRN2_ENST00000404321.2_Missense_Mutation_p.E548K|PTPRN2_ENST00000389418.4_Missense_Mutation_p.E525K			Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	525						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CGCCTTCCTTCCTCGGGGCGC	0.667000													4	5					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32037621	32037621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32037621C>T	ENST00000375244.3	-	15	5497	c.5296G>A	c.(5296-5298)Gat>Aat	p.D1766N	TNXB_ENST00000375247.2_Missense_Mutation_p.D1766N			P22105	TENX_HUMAN	tenascin XB	1848	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCAGTATCATCCATAGCACTC	0.602000													9	27					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55277722	55277722	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55277722A>T	ENST00000358193.3	+	6	676	c.622A>T	c.(622-624)Agt>Tgt	p.S208C	C1orf177_ENST00000371273.3_Missense_Mutation_p.S208C	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	208										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						GCTCTAGGGGAGTGGTCTGGG	0.622000													26	124					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38758068	38758068	+	Missense_Mutation	SNP	G	G	A	rs145862170		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38758068G>A	ENST00000359357.3	+	18	2271	c.2017G>A	c.(2017-2019)Gaa>Aaa	p.E673K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E890K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E673K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTTCTAGGTGGAATCTGTGTT	0.353000													19	139					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	77004407	77004407	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:77004407G>A	ENST00000257626.7	-	11	831	c.753C>T	c.(751-753)ccC>ccT	p.P251P		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		ATATGTCCAAGGGTACTTCAA	0.318000													11	40					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46230641	46230641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:46230641C>T	ENST00000334344.6	+	8	1062	c.890C>T	c.(889-891)tCc>tTc	p.S297F	ARID2_ENST00000422737.1_Missense_Mutation_p.S148F|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	297					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AGAAATCTTTCCTTTGAGGAG	0.398000			"""N, S, F"""		hepatocellular carcinoma								45	85					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41000874	41000874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41000874C>T	ENST00000352632.3	+	6	744	c.658C>T	c.(658-660)Cac>Tac	p.H220Y	SPTBN4_ENST00000344104.3_Missense_Mutation_p.H220Y|SPTBN4_ENST00000595535.1_Missense_Mutation_p.H220Y|SPTBN4_ENST00000598249.1_Missense_Mutation_p.H220Y|SPTBN4_ENST00000338932.3_Missense_Mutation_p.H220Y			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	220	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGCCCTCATTCACCGGCACAG	0.572000													21	42					0	0	1	0	0
PRLHR	2834	broad.mit.edu	37	10	120354453	120354453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:120354453G>A	ENST00000239032.2	-	2	442	c.304C>T	c.(304-306)Ctg>Ttg	p.L102L	PRLHR_ENST00000369169.1_Silent_p.L102L	NM_004248.2	NP_004239.1	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	102					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GACAAGGCCAGGTTGCCGATG	0.687000													29	58					0	0	1	0	0
QSER1	79832	broad.mit.edu	37	11	32955532	32955532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:32955532C>T	ENST00000399302.2	+	4	2676	c.2341C>T	c.(2341-2343)Cat>Tat	p.H781Y	QSER1_ENST00000527788.1_Missense_Mutation_p.H542Y	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	781	Gln-rich.									breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					CAATGGTGATCATTCTCAGCA	0.403000													33	108					0	0	1	0	0
ZFP57	346171	broad.mit.edu	37	6	29640975	29640975	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29640975G>A	ENST00000376883.1	-	6	1264	c.853C>T	c.(853-855)Cag>Tag	p.Q285*	ZFP57_ENST00000488757.1_Nonsense_Mutation_p.Q305*|ZFP57_ENST00000376881.3_Nonsense_Mutation_p.Q285*			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	221					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						ATGGGTGTCTGGAATTCAGCC	0.542000													53	132					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874097	36874097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36874097G>A	ENST00000301807.6	-	21	7092	c.5195C>T	c.(5194-5196)tCc>tTc	p.S1732F	TRANK1_ENST00000429976.2_Missense_Mutation_p.S2282F|TRANK1_ENST00000428977.2_Missense_Mutation_p.S1732F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2282					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CAGGTCTGTGGATTCCCGGCG	0.483000													19	42					0	0	1	0	0
NEXN	91624	broad.mit.edu	37	1	78392180	78392180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:78392180G>A	ENST00000330010.8	+	6	676	c.379G>A	c.(379-381)Gat>Aat	p.D127N	NEXN_ENST00000334785.7_Missense_Mutation_p.D191N|NEXN_ENST00000457030.1_Missense_Mutation_p.D177N	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	191	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		GAATTTTGAGGATCTAGAAAA	0.318000													9	97					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069208	6069208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:6069208G>A	ENST00000381095.3	-	2	927	c.300C>T	c.(298-300)atC>atT	p.I100I	NLGN4X_ENST00000538097.1_Silent_p.I100I|NLGN4X_ENST00000275857.6_Silent_p.I100I|NLGN4X_ENST00000381093.2_Silent_p.I100I|NLGN4X_ENST00000381092.1_Silent_p.I100I|NLGN4X_ENST00000469740.1_5'UTR	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	100					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						TAGTATTTCGGATGCCAGTCC	0.572000													24	48					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32012969	32012969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32012969C>T	ENST00000375244.3	-	32	10942	c.10741G>A	c.(10741-10743)Ggc>Agc	p.G3581S	TNXB_ENST00000451343.1_Missense_Mutation_p.G10S|TNXB_ENST00000375247.2_Missense_Mutation_p.G3579S			P22105	TENX_HUMAN	tenascin XB	3626					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCAAAGGGGCCCTGGGCCACG	0.647000													15	40					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795252	142795252	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142795252G>A	ENST00000370498.1	-	2	1179	c.426C>T	c.(424-426)gaC>gaT	p.D142D		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	142										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCAGATGAGTCCAGGTCTT	0.522000													36	215					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155450702	155450702	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155450702C>T	ENST00000461783.3	+	6	1618	c.345C>T	c.(343-345)ggC>ggT	p.G115G	TIAM2_ENST00000456144.1_Silent_p.G115G|TIAM2_ENST00000318981.5_Silent_p.G115G|TIAM2_ENST00000360366.4_Silent_p.G115G|TIAM2_ENST00000529824.2_Silent_p.G115G|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	115					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTGAGAATGGCTTCCACTCTG	0.542000													17	19					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39871124	39871124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39871124G>A	ENST00000502986.2	+	10	1041	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	IDO2_ENST00000389060.4_Missense_Mutation_p.E254K|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	254					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						GCTGATGTATGAAGGAGTTTC	0.483000													18	77					0	0	1	0	0
HSF2BP	11077	broad.mit.edu	37	21	45012194	45012194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45012194G>A	ENST00000291560.2	-	8	1039	c.708C>T	c.(706-708)tcC>tcT	p.S236S	HSF2BP_ENST00000542962.1_Silent_p.S161S	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	236					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		CATTGTATAGGGACATCAGCA	0.418000													21	56					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510379	56510379	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56510379G>A	ENST00000302957.3	-	1	908	c.909C>T	c.(907-909)ctC>ctT	p.L303L		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGCTATAGATGAGAGGGTTGA	0.433000													37	92					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28617510	28617510	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28617510G>A	ENST00000395609.1	-	9	1400	c.642C>T	c.(640-642)tcC>tcT	p.S214S	SULT1A1_ENST00000569554.1_Silent_p.S214S|SULT1A1_ENST00000314752.7_Silent_p.S214S|SULT1A1_ENST00000350842.4_Silent_p.S136S|SULT1A1_ENST00000395607.1_Silent_p.S214S			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	214					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						CCTCTGGCAGGGAGCGCCCCA	0.547000													26	134					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213014	9213014	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9213014C>T	ENST00000305456.2	-	1	968	c.969G>A	c.(967-969)agG>agA	p.R323R		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						CTATGAACTTCCTCAAGGTTC	0.443000													19	60					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2608837	2608837	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2608837C>T	ENST00000155840.5	+	9	1274	c.1166C>T	c.(1165-1167)tCc>tTc	p.S389F	KCNQ1_ENST00000335475.5_Missense_Mutation_p.S262F	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	389					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	AACCCCGACTCCTCCACCTGG	0.642000													46	99					0	0	1	0	0
NIPSNAP1	8508	broad.mit.edu	37	22	29956781	29956781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29956781C>T	ENST00000216121.7	-	8	902	c.648G>A	c.(646-648)gaG>gaA	p.E216E		NM_001202502.1|NM_003634.3	NP_001189431.1|NP_003625.2	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1 (C. elegans)	216								p.?(1)		large_intestine(2)|lung(2)|skin(1)	5						CGCCCACTGCCTCCTGGTTCT	0.557000													51	128					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187509969	187509969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187509969G>A	ENST00000441802.2	-	27	13753	c.13544C>T	c.(13543-13545)cCc>cTc	p.P4515L		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4515					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGGGGCATGGGGTTCTCTACA	0.517000										HNSCC(5;0.00058)			20	57					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45678478	45678478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45678478G>A	ENST00000270172.3	-	6	927	c.444C>T	c.(442-444)tcC>tcT	p.S148S	DNMT3L_ENST00000418993.1_Silent_p.S148S	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	148	ADD.				DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		CGCTTCGGGAGGACGGCAGGC	0.662000													6	26					0	0	1	0	0
OR1L3	26735	broad.mit.edu	37	9	125437455	125437455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125437455G>A	ENST00000304820.2	+	1	141	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						ATTCTCTTGGGACTCTCCTCT	0.423000													37	118					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642421	57642421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57642421G>A	ENST00000254181.4	+	4	2832	c.2378G>A	c.(2377-2379)gGa>gAa	p.G793E	USP29_ENST00000598197.1_Missense_Mutation_p.G793E	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	793					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GACAACCCAGGAAACAAAAAC	0.468000													6	27					0	0	1	0	0
C16orf54	283897	broad.mit.edu	37	16	29755651	29755651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29755651C>T	ENST00000329410.3	-	2	717	c.622G>A	c.(622-624)Gag>Aag	p.E208K		NM_175900.3	NP_787096.2	Q6UWD8	CP054_HUMAN	chromosome 16 open reading frame 54	208						integral to membrane				breast(1)|central_nervous_system(1)|lung(2)|prostate(1)|urinary_tract(1)	6						GAGATCTGCTCCAAGGTGACC	0.667000													5	22					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602719	96602719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96602719C>T	ENST00000371321.3	+	7	1169	c.1087C>T	c.(1087-1089)Ccc>Tcc	p.P363S	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	363					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CGACCTCATCCCCACCAGCCT	0.532000													44	142					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45312480	45312480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45312480G>A	ENST00000313237.5	-	4	394	c.244C>T	c.(244-246)Ctc>Ttc	p.L82F	PHF21B_ENST00000404079.2_Missense_Mutation_p.L70F|PHF21B_ENST00000396103.3_Missense_Mutation_p.L82F|PHF21B_ENST00000403565.1_5'UTR|PHF21B_ENST00000447824.3_Missense_Mutation_p.L70F	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	82							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GCAACGGGGAGGCTGTCTGGA	0.657000													32	53					0	0	1	0	0
HIBCH	26275	broad.mit.edu	37	2	191117026	191117026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:191117026G>A	ENST00000392332.3	-	8	664	c.525C>T	c.(523-525)ttC>ttT	p.F175F	HIBCH_ENST00000359678.5_Silent_p.F175F			Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-CoA hydrolase	175					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding	p.F175L(1)		NS(1)|breast(2)|endometrium(1)|large_intestine(1)|lung(5)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			CCACATCAGGGAACAGTCCTG	0.363000													15	38					0	0	1	0	0
ZNF474	133923	broad.mit.edu	37	5	121488406	121488406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121488406C>T	ENST00000296600.4	+	2	1104	c.721C>T	c.(721-723)Ccc>Tcc	p.P241S	ZNF474_ENST00000514925.1_Intron|CTC-441N14.2_ENST00000504829.1_RNA	NM_207317.1	NP_997200.1	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	241						intracellular	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|stomach(1)	21		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		TATTCATGAGCCCAAATGCCT	0.527000													30	107					0	0	1	0	0
TRBC2	28638	broad.mit.edu	37	7	142499852	142499852	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142499852C>T	ENST00000466254.1	+	0	469																											GGGAAGGCCACCTTGTATGCC	0.557000													13	42					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	66878844	66878844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:66878844C>T	ENST00000544246.1	-	5	4348	c.3657G>A	c.(3655-3657)ctG>ctA	p.L1219L	PCDH9-AS1_ENST00000430861.1_RNA|PCDH9_ENST00000377865.2_Silent_p.L1219L|PCDH9_ENST00000456367.1_Silent_p.L1185L|PCDH9_ENST00000328454.5_Silent_p.L1185L	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1219					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TATAAGACTTCAGATTTGCCA	0.438000													20	65					0	0	1	0	0
TTC39B	158219	broad.mit.edu	37	9	15203859	15203859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:15203859C>T	ENST00000355694.2	-	7	757	c.523G>A	c.(523-525)Gag>Aag	p.E175K	TTC39B_ENST00000507285.1_Missense_Mutation_p.E76K|TTC39B_ENST00000512701.1_Missense_Mutation_p.E241K|TTC39B_ENST00000380850.4_Missense_Mutation_p.E241K|TTC39B_ENST00000297615.5_Missense_Mutation_p.E172K|TTC39B_ENST00000541445.1_Missense_Mutation_p.E175K|TTC39B_ENST00000507993.1_Missense_Mutation_p.E76K	NM_001168339.1|NM_152574.2	NP_001161811.1|NP_689787.2	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	175							binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)	21						AGGAGACACTCGGCATAACAG	0.388000													11	27					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	484774	484774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:484774C>T	ENST00000264938.3	-	5	802	c.793G>A	c.(793-795)Ggg>Agg	p.G265R	SLC9A3_ENST00000514375.1_Missense_Mutation_p.G265R	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	265						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AAGACCACCCCCACCAGCGTG	0.642000													29	66					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124269	142124269	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142124269G>A	ENST00000390376.2	-	0	208																											AGTACCAGCAGCAGCTGAGTA	0.517000													42	174					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161954026	161954026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161954026G>A	ENST00000294794.3	-	8	2115	c.1692C>T	c.(1690-1692)atC>atT	p.I564I	OLFML2B_ENST00000367938.1_Silent_p.I47I|OLFML2B_ENST00000367940.2_Silent_p.I565I	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	564	Olfactomedin-like.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGCCTGTGCCGATCCAGCTGT	0.582000													19	73					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48678422	48678422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48678422C>T	ENST00000352832.5	+	18	4105	c.3733C>T	c.(3733-3735)Ctg>Ttg	p.L1245L	CACNA1G_ENST00000512389.1_Silent_p.L1268L|CACNA1G_ENST00000507336.1_Silent_p.L1268L|CACNA1G_ENST00000507609.1_Silent_p.L1268L|CACNA1G_ENST00000354983.4_Silent_p.L1245L|CACNA1G_ENST00000503485.1_Silent_p.L1268L|CACNA1G_ENST00000507896.1_Silent_p.L1268L|CACNA1G_ENST00000358244.5_Silent_p.L1245L|CACNA1G_ENST00000510115.1_Silent_p.L1245L|CACNA1G_ENST00000510366.1_Silent_p.L1268L|CACNA1G_ENST00000502264.1_Silent_p.L1245L|CACNA1G_ENST00000429973.2_Silent_p.L1268L|CACNA1G_ENST00000416767.4_Silent_p.L1268L|CACNA1G_ENST00000360761.4_Silent_p.L1245L|CACNA1G_ENST00000515765.1_Silent_p.L1268L|CACNA1G_ENST00000515411.1_Silent_p.L1268L|CACNA1G_ENST00000442258.2_Silent_p.L1245L|CACNA1G_ENST00000515165.1_Silent_p.L1268L|CACNA1G_ENST00000505165.1_Silent_p.L1268L|CACNA1G_ENST00000359106.5_Silent_p.L1268L|CACNA1G_ENST00000514717.1_Silent_p.L1245L|CACNA1G_ENST00000514181.1_Silent_p.L1268L|CACNA1G_ENST00000514079.1_Silent_p.L1268L|CACNA1G_ENST00000513964.1_Silent_p.L1268L|CACNA1G_ENST00000507510.2_Silent_p.L1268L|CACNA1G_ENST00000513689.2_Silent_p.L1268L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1268					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTTCCGCCTCCTGTGTCACCG	0.622000													55	87					0	0	1	0	0
SLC45A3	85414	broad.mit.edu	37	1	205632186	205632186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205632186G>A	ENST00000367145.3	-	3	1028	c.733C>T	c.(733-735)Cgg>Tgg	p.R245W		NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	245					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			AAGCGGGCCCGGCATGGACAG	0.716000			T	"""ETV1, ETV5, ELK4, ERG"""	prostate								11	22					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400298	85400298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85400298G>A	ENST00000258888.5	+	6	3102	c.2935G>A	c.(2935-2937)Gag>Aag	p.E979K		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	979					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGATCTGAGGAGGCAGTAGT	0.542000													56	171					0	0	1	0	0
LRRC37BP1	147172	broad.mit.edu	37	17	28958810	28958810	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:28958810C>T	ENST00000412831.1	+	0	38				SMURF2P1_ENST00000578265.1_RNA																							AAGGAGCATTCATGAAGATGT	0.463000													86	109					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50118201	50118201	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50118201G>A	ENST00000281631.5	+	17	1985	c.1827G>A	c.(1825-1827)ctG>ctA	p.L609L	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505697.2_Silent_p.L609L|PARP8_ENST00000503750.2_Silent_p.L567L|PARP8_ENST00000505554.1_Silent_p.L588L|PARP8_ENST00000514067.2_Silent_p.L567L|PARP8_ENST00000514342.2_Silent_p.L320L	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	609						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				TGAAAGCACTGGATAGCATAA	0.323000													43	103					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102509599	102509599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:102509599C>T	ENST00000321521.9	+	21	3025	c.2452C>T	c.(2452-2454)Cgt>Tgt	p.R818C	PPIP5K2_ENST00000358359.3_Missense_Mutation_p.R818C|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.R818C|PPIP5K2_ENST00000513500.1_3'UTR			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	818					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						ACGTCATGTTCGTACTAGATT	0.333000													21	100					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24576801	24576801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24576801C>T	ENST00000535378.1	-	11	2144	c.1502G>A	c.(1501-1503)gGa>gAa	p.G501E	KIAA0319_ENST00000378214.3_Missense_Mutation_p.G510E|KIAA0319_ENST00000430948.2_Missense_Mutation_p.G465E|KIAA0319_ENST00000543707.1_Missense_Mutation_p.G510E|KIAA0319_ENST00000537886.1_Missense_Mutation_p.G510E	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	510	PKD 2.				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GTTAGTGGCTCCGTCCGAGTC	0.488000													32	314					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081132	152081132	+	Missense_Mutation	SNP	C	C	T	rs71585886		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152081132C>T	ENST00000368804.1	-	2	4560	c.4561G>A	c.(4561-4563)Gaa>Aaa	p.E1521K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1521	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGCTGTTCCTCCTCGAGG	0.607000													25	128					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292792	4292792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4292792C>T	ENST00000301272.2	-	5	698	c.653G>A	c.(652-654)gGc>gAc	p.G218D	TMIGD2_ENST00000600114.1_Missense_Mutation_p.G98D|TMIGD2_ENST00000600349.1_Missense_Mutation_p.G46D|TMIGD2_ENST00000595645.1_Missense_Mutation_p.G214D	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	218						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		AATGCTCTGGCCCCTCTGGTC	0.647000													23	88					0	0	1	0	0
OSBPL8	114882	broad.mit.edu	37	12	76780412	76780412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:76780412G>A	ENST00000261183.3	-	13	1860	c.1381C>T	c.(1381-1383)Cgt>Tgt	p.R461C	OSBPL8_ENST00000393249.2_Missense_Mutation_p.R419C|OSBPL8_ENST00000393250.4_Missense_Mutation_p.R419C	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	461					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						TTCTTCAAACGGAAATAAGGA	0.274000													13	121					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92307812	92307812	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:92307812C>T	ENST00000276609.3	+	4	597	c.358C>T	c.(358-360)Cct>Tct	p.P120S	SLC26A7_ENST00000523719.1_Missense_Mutation_p.P120S|SLC26A7_ENST00000309536.2_Missense_Mutation_p.P120S	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	120						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			ACGGATTGTCCCTCAGAACAT	0.458000													31	89					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059983	152059983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152059983G>A	ENST00000368806.1	-	3	239	c.175C>T	c.(175-177)Ctt>Ttt	p.L59F		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	59	EF-hand.						calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ATATTCAGAAGATTTGAATTT	0.363000													32	48					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21631159	21631159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21631159C>T	ENST00000328843.6	+	14	2662	c.2631C>T	c.(2629-2631)atC>atT	p.I877I	DNAH11_ENST00000409508.3_Silent_p.I877I			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	877	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ACAAGTTAATCCAAGGAGATG	0.443000									Kartagener syndrome				35	74					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29007989	29007989	+	Silent	SNP	C	C	T	rs56405013	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29007989C>T	ENST00000282397.4	-	6	1031	c.780G>A	c.(778-780)acG>acA	p.T260T	FLT1_ENST00000539099.1_Silent_p.T260T|FLT1_ENST00000541932.1_Silent_p.T260T	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	260	Ig-like C2-type 3.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TTTGAACTCTCGTGTTCAAGG	0.433000													40	84					0	0	1	0	0
GNL1	2794	broad.mit.edu	37	6	30521163	30521163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30521163G>A	ENST00000376621.3	-	6	1742	c.772C>T	c.(772-774)Cct>Tct	p.P258S		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	258					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						GGGTCCCGAGGAAAAGAGGTG	0.572000													52	166					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20790154	20790154	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20790154G>A	ENST00000359062.3	+	9	2162	c.2122G>A	c.(2122-2124)Ggc>Agc	p.G708S	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	708					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AAGAAAATGTGGCCGTATTCT	0.338000													9	32					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507732	155507732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155507732C>T	ENST00000302053.3	-	5	927	c.849G>A	c.(847-849)acG>acA	p.T283T	FGA_ENST00000403106.3_Silent_p.T283T	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	283					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TGGGGCTTTCCGTCTCTGATC	0.542000													53	133					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47219479	47219479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47219479G>A	ENST00000300404.2	+	3	537	c.478G>A	c.(478-480)Gac>Aac	p.D160N	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.D74N|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.D100N	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	160					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TGGCCAGAGCGACCTCCCAGC	0.498000													38	100					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	825636	825636	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:825636C>T	ENST00000293892.3	-	5	1124	c.1125G>A	c.(1123-1125)ggG>ggA	p.G375G	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	103					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						TCGGGTCATCCCCACGGCCAC	0.716000													17	13					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3304454	3304454	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3304454C>T	ENST00000219596.1	-	2	653	c.614G>A	c.(613-615)aGa>aAa	p.R205K	MEFV_ENST00000541159.1_Intron|MEFV_ENST00000339854.4_Intron|MEFV_ENST00000536379.1_Intron	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	205					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	GCTGGCGTTTCTGCGCAGCCG	0.756000													10	21					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37354527	37354527	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37354527C>T	ENST00000310758.4	-	4	767		c.e4-1		ELMO1_ENST00000448602.1_Splice_Site|ELMO1_ENST00000442504.1_Splice_Site	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1						actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						AAGAGACCACCTTAAAAATAC	0.343000													7	30					0	0	1	0	0
FEZ2	9637	broad.mit.edu	37	2	36810533	36810533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:36810533G>A	ENST00000379245.4	-	3	503	c.455C>T	c.(454-456)tCc>tTc	p.S152F	FEZ2_ENST00000305852.7_5'UTR|FEZ2_ENST00000405912.3_Missense_Mutation_p.S152F	NM_001042548.1	NP_001036013.1	Q9UHY8	FEZ2_HUMAN	fasciculation and elongation protein zeta 2 (zygin II)	152					axon guidance|signal transduction		protein binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	7		all_hematologic(82;0.21)				ATTAACACAGGAGACGATGAT	0.443000													29	77					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999549	46999549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46999549C>T	ENST00000374314.4	+	1	1624	c.669C>T	c.(667-669)acC>acT	p.T223T	GPRIN2_ENST00000374317.1_Silent_p.T223T			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	223										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						AGCTGGCTACCACCACCTGCC	0.637000													13	39					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55378071	55378071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55378071C>T	ENST00000326321.3	+	9	1286	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.P418L|KIR3DL2_ENST00000270442.5_Missense_Mutation_p.P401L	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	418					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		TCTCAGAGGCCCAAGACACCC	0.522000													34	393					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674097	167674097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167674097G>A	ENST00000519204.1	+	26	5908	c.5790G>A	c.(5788-5790)atG>atA	p.M1930I	TENM2_ENST00000403607.2_Missense_Mutation_p.M1875I|TENM2_ENST00000545108.1_Missense_Mutation_p.M2050I|TENM2_ENST00000518659.1_Missense_Mutation_p.M2051I|TENM2_ENST00000520394.1_Missense_Mutation_p.M1812I					teneurin transmembrane protein 2																		TCTTGAAGATGGTCAACCTCC	0.527000													32	72					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56220307	56220307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56220307C>T	ENST00000332836.2	-	9	2974	c.2947G>A	c.(2947-2949)Gaa>Aaa	p.E983K	CTD-2611O12.8_ENST00000596293.1_RNA	NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	983						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ATCTTGTATTCCTCGTCAATC	0.488000													26	83					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158549183	158549183	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158549183G>A	ENST00000368150.1	-	1	506	c.507C>T	c.(505-507)ttC>ttT	p.F169F		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F169F(1)		breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					GAGAGATAAAGAAGCCTGCAG	0.468000													17	35					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56757193	56757193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56757193G>A	ENST00000326855.2	+	1	847	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E269K(1)		breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						TAATTCCCAGGAAAATATGAA	0.353000													30	59					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92844872	92844872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92844872C>T	ENST00000394468.2	-	3	634	c.557G>A	c.(556-558)gGg>gAg	p.G186E	HEPACAM2_ENST00000440868.1_Missense_Mutation_p.G174E|HEPACAM2_ENST00000453812.2_Missense_Mutation_p.G209E|HEPACAM2_ENST00000341723.4_Missense_Mutation_p.G174E	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	186	Ig-like C2-type 1.					integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						GACAGGTCTCCCATTTTTTAG	0.507000													22	81					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111154921	111154921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111154921C>T	ENST00000280325.4	+	3	275	c.128C>T	c.(127-129)cCc>cTc	p.P43L		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	43										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		AAGCCGTTTCCCTGTGAGTCC	0.572000													62	175					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595095	179595095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179595095G>A	ENST00000589042.1	-	62	18256	c.18032C>T	c.(18031-18033)cCc>cTc	p.P6011L	TTN_ENST00000342992.6_Missense_Mutation_p.P4767L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.P5694L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5694	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAGTAAGGGGGTTCTGAGGT	0.353000													6	16					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53326422	53326422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:53326422C>T	ENST00000395631.2	-	14	1954	c.1738G>A	c.(1738-1740)Ggc>Agc	p.G580S	FERMT2_ENST00000343279.4_Missense_Mutation_p.G587S|FERMT2_ENST00000399304.3_Missense_Mutation_p.G587S|FERMT2_ENST00000341590.3_Missense_Mutation_p.G580S|FERMT2_ENST00000557255.1_5'UTR|FERMT2_ENST00000553373.1_Missense_Mutation_p.G587S			Q96AC1	FERM2_HUMAN	fermitin family member 2	580	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					TCTTTTTTGCCCCCTTGGAAC	0.398000													7	27					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208200648	208200648	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:208200648C>T	ENST00000367033.3	-	32	6382	c.5625G>A	c.(5623-5625)cgG>cgA	p.R1875R	PLXNA2_ENST00000483048.1_5'UTR	NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1875					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GCCGCTGCCGCCGTGCCTGCT	0.547000													29	85					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56467449	56467449	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56467449C>T	ENST00000291971.3	+	3	2096	c.2025C>T	c.(2023-2025)agC>agT	p.S675S	NLRP8_ENST00000590542.1_Silent_p.S675S	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	675						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TCAGCTCCAGCTCCCATCCTG	0.547000													28	78					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540021	94540021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94540021C>T	ENST00000289495.5	+	1	812	c.596C>T	c.(595-597)tCc>tTc	p.S199F	PPP1R9A_ENST00000340694.4_Missense_Mutation_p.S199F|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.S199F|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.S199F|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.S199F|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.S199F	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	199						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GAGGCTGTCTCCCCAACTGTG	0.502000										HNSCC(28;0.073)			17	44					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455863	5455863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5455863G>A	ENST00000222033.4	+	1	438	c.361G>A	c.(361-363)Ggc>Agc	p.G121S		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	121						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GGCGCTGTTCGGCGTCCCCCT	0.687000													18	112					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332550	100332550	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:100332550G>A	ENST00000341853.1	-	0	1641				AC090825.1_ENST00000408584.1_RNA	NR_003260.1																						GGCCGTCGGAGGGACCTCAGC	0.582000													14	132					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11067975	11067975	+	Silent	SNP	C	C	T	rs144261418		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11067975C>T	ENST00000287766.4	+	10	1429	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	SLC6A1_ENST00000536032.1_Silent_p.F158F	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	336					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCGCAGGATTCGTCATCTTCT	0.592000													35	103					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611058	179611058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179611058G>A	ENST00000360870.5	-	46	16291	c.16069C>T	c.(16069-16071)Cca>Tca	p.P5357S	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8870	Ig-like 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCATATTTGGATCTACAAAA	0.333000													26	49					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390946	197390946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197390946C>T	ENST00000367397.1	+	2	989	c.131C>T	c.(130-132)tCa>tTa	p.S44L	CRB1_ENST00000535699.1_Missense_Mutation_p.S594L|CRB1_ENST00000543483.1_Missense_Mutation_p.H293Y|CRB1_ENST00000367400.3_Missense_Mutation_p.S663L|CRB1_ENST00000538660.1_Missense_Mutation_p.S663L|CRB1_ENST00000544212.1_Missense_Mutation_p.S144L|CRB1_ENST00000367399.2_Missense_Mutation_p.S551L			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	663	EGF-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TCTGGCTCATCATTAAATGTC	0.443000													17	162					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189586379	189586379	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189586379C>T	ENST00000264731.3	+	8	1092	c.1003C>T	c.(1003-1005)Ctg>Ttg	p.L335L	TP63_ENST00000392460.3_Silent_p.L335L|TP63_ENST00000449992.1_Silent_p.L156L|TP63_ENST00000392463.2_Silent_p.L241L|TP63_ENST00000440651.2_Silent_p.L335L|TP63_ENST00000320472.5_Silent_p.L335L|TP63_ENST00000392461.3_Silent_p.L241L|TP63_ENST00000382063.4_Silent_p.L250L|TP63_ENST00000456148.1_Silent_p.L241L|TP63_ENST00000437221.1_Silent_p.L241L|TP63_ENST00000354600.5_Silent_p.L241L|TP63_ENST00000418709.2_Silent_p.L335L	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	335					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGGGCAAGTCCTGGGCCGACG	0.488000										HNSCC(45;0.13)			21	58					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68597784	68597784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68597784C>T	ENST00000570495.1	+	5	1386	c.1094C>T	c.(1093-1095)cCc>cTc	p.P365L	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.P365L|ZFP90_ENST00000563169.2_Missense_Mutation_p.P365L			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	365					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		GGAGAGAAGCCCTTCCAGTGT	0.473000													13	46					0	0	1	0	0
REEP3	221035	broad.mit.edu	37	10	65379552	65379552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:65379552C>T	ENST00000373758.4	+	7	886	c.703C>T	c.(703-705)Cgc>Tgc	p.R235C	REEP3_ENST00000298249.4_Missense_Mutation_p.R220C	NM_001001330.2	NP_001001330.1	Q6NUK4	REEP3_HUMAN	receptor accessory protein 3	235						integral to membrane				endometrium(1)|large_intestine(2)|lung(3)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CACCAAAGGCCGCAAAGAGGT	0.398000													4	12					0	0	1	0	0
TRIM22	10346	broad.mit.edu	37	11	5730807	5730807	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5730807C>T	ENST00000379965.3	+	8	1703	c.1426C>T	c.(1426-1428)Cga>Tga	p.R476*	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	476	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TCGCTTTTCTCGACCTGCTTA	0.473000													53	176					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23543378	23543378	+	Missense_Mutation	SNP	T	T	G	rs1821843		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23543378T>G	ENST00000300619.7	-	4	2608	c.2403A>C	c.(2401-2403)gaA>gaC	p.E801D	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.E769D	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	801						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGCCACATTCTTCACATTTGT	0.393000													27	106					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157485638	157485638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157485638C>T	ENST00000361835.3	-	16	2995	c.2838G>A	c.(2836-2838)agG>agA	p.R946R	FCRL5_ENST00000356953.4_Silent_p.R946R|FCRL5_ENST00000461387.1_5'UTR	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	946						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TCACCTTGTTCCTGAGATGCC	0.602000													26	55					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36751979	36751979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36751979C>T	ENST00000354618.5	+	4	372	c.148C>T	c.(148-150)Cgt>Tgt	p.R50C	THRAP3_ENST00000469141.2_Missense_Mutation_p.R50C	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	50	Arg-rich.|Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTCTAGGTCTCGTTCCAGATC	0.398000			T	USP6	aneurysmal bone cysts								50	93					0	0	1	0	0
BMP15	9210	broad.mit.edu	37	X	50653837	50653837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50653837C>T	ENST00000252677.3	+	1	54	c.54C>T	c.(52-54)ttC>ttT	p.F18F		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	18					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					TCGTGCTTTTCATGGAACACA	0.493000													5	14					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95719456	95719456	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95719456C>T	ENST00000480546.1	-	0	1841					NR_002319.2																						TGATCTTGCCCTTGGGTTGGA	0.532000													14	26					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60557857	60557857	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60557857C>T	ENST00000308287.1	+	2	145	c.49C>T	c.(49-51)Cca>Tca	p.P17S		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	17						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						TAGGGGGCTCCCATCATGGCA	0.617000													30	86					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111964021	111964021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111964021G>A	ENST00000369732.3	-	8	835	c.780C>T	c.(778-780)atC>atT	p.I260I	OVGP1_ENST00000540696.1_Intron|OVGP1_ENST00000481495.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	260					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CATAGGTGGGGATCCCCATGA	0.512000													32	97					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22846939	22846939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22846939C>T	ENST00000283645.4	+	8	944	c.814C>T	c.(814-816)Cgg>Tgg	p.R272W	TUBGCP5_ENST00000453949.2_Missense_Mutation_p.R272W	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	272					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TCAGGTTATTCGGGAAACCCT	0.353000													17	72					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100378688	100378688	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100378688G>A	ENST00000273352.3	+	14	2247		c.e14+1		GPR128_ENST00000475887.1_Splice_Site|GPR128_ENST00000481506.1_Splice_Site	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						ACCTGACAAGGTAAGATTCCC	0.428000													16	45					0	0	1	0	0
PISD	23761	broad.mit.edu	37	22	32017780	32017780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32017780G>A	ENST00000382151.2	-	4	730	c.311C>T	c.(310-312)cCc>cTc	p.P104L	PISD_ENST00000336566.4_Missense_Mutation_p.P138L|PISD_ENST00000439502.2_Missense_Mutation_p.P138L|PISD_ENST00000478893.1_5'UTR|PISD_ENST00000266095.5_Missense_Mutation_p.P104L|PISD_ENST00000397500.1_Missense_Mutation_p.P104L			Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	138					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(3)|endometrium(2)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12					Phosphatidylserine(DB00144)	GCTGTAGACGGGCCTGCGCAG	0.617000													39	53					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2026852	2026852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2026852G>A	ENST00000262113.4	+	12	1441	c.1300G>A	c.(1300-1302)Gat>Aat	p.D434N	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	434	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GCAGTGCAATGATGCACCGGT	0.428000													45	179					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98039469	98039469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:98039469C>T	ENST00000370192.3	-	11	1286	c.1186G>A	c.(1186-1188)Gtt>Att	p.V396I		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	396					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TTTACTATAACCTTCCGTGGG	0.388000													24	74					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55069580	55069580	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55069580C>T	ENST00000371316.3	+	11	1204	c.1122C>T	c.(1120-1122)ccC>ccT	p.P374P	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000343744.2_Silent_p.P374P	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	374					fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						CAGAGGTGCCCCTCTCCGTCC	0.577000													33	76					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57117373	57117373	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57117373G>A	ENST00000263314.2	+	7	739		c.e7+1			NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3						positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						GGCGCGCACGGTGAGGACCTA	0.637000											OREG0020966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	30					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073281	134073281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:134073281C>T	ENST00000264360.4	+	1	2812	c.1986C>T	c.(1984-1986)gaC>gaT	p.D662D		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	662	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		AGGTGCGCGACCATGGGCAGC	0.726000													6	36					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766120	77766120	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77766120C>T	ENST00000521891.2	+	10	7411	c.6963C>T	c.(6961-6963)ttC>ttT	p.F2321F	ZFHX4_ENST00000050961.6_Silent_p.F2276F|ZFHX4_ENST00000455469.2_Silent_p.F2276F|ZFHX4_ENST00000518282.1_Silent_p.F2295F	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2276						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATGTGGTTTTCCCCAGGATCT	0.393000										HNSCC(33;0.089)			20	41					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124528957	124528957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:124528957C>T	ENST00000408936.3	+	9	1827	c.1645C>T	c.(1645-1647)Cgc>Tgc	p.R549C	DAB2IP_ENST00000309989.1_Missense_Mutation_p.R425C|DAB2IP_ENST00000259371.2_Missense_Mutation_p.R521C			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	549	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						CCGCACTGCCCGCACCCTCAC	0.627000													25	184					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562537	140562537	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140562537G>A	ENST00000361016.2	+	1	1558	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		135					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATGTTCACTGAAAAGGAAAT	0.378000													18	49					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121301912	121301912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121301912G>A	ENST00000297848.3	+	34	4413	c.4143G>A	c.(4141-4143)aaG>aaA	p.K1381K	COL14A1_ENST00000247781.3_Silent_p.K1286K|COL14A1_ENST00000309791.4_Silent_p.K1381K	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1381	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGGTGAGAAGGCAATGAACG	0.438000													36	67					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38768370	38768370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38768370G>A	ENST00000449082.2	-	16	2813	c.2814C>T	c.(2812-2814)ttC>ttT	p.F938F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	938					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGGGCTGGGGGAATGGGCAGG	0.602000													27	83					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18715676	18715676	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18715676G>A	ENST00000433979.1	+	26	3623	c.3507G>A	c.(3505-3507)ttG>ttA	p.L1169L	PIK3C2G_ENST00000266497.5_Silent_p.L1169L|PIK3C2G_ENST00000538779.1_Silent_p.L1210L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1169	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CTGTTAAATTGAATAACTTGA	0.383000													4	18					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177686749	177686749	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:177686749C>T	ENST00000390654.3	-	12	1060		c.e12-1		COL23A1_ENST00000407622.1_Splice_Site	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1							collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CAGGCTCACCCTGGGGGAGGC	0.607000													52	165					0	0	1	0	0
IFI27L1	122509	broad.mit.edu	37	14	94563264	94563264	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94563264C>T	ENST00000553664.1	+	3	173	c.48C>T	c.(46-48)caC>caT	p.H16H	IFI27L1_ENST00000553350.1_3'UTR|IFI27L1_ENST00000557218.1_5'UTR|IFI27L1_ENST00000554544.1_5'UTR|IFI27L1_ENST00000393115.3_5'UTR|IFI27L1_ENST00000555523.1_5'UTR|IFI27L1_ENST00000556381.1_5'UTR|IFI27L1_ENST00000554562.1_5'UTR|IFI27L1_ENST00000557066.1_5'UTR			Q96BM0	I27L1_HUMAN	interferon, alpha-inducible protein 27-like 1	0						integral to membrane				lung(2)	2						TGGAGGCTCACCGAGGCGAAG	0.507000													6	19					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133502261	133502261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:133502261C>T	ENST00000253861.4	+	11	1727	c.1698C>T	c.(1696-1698)acC>acT	p.T566T	EXOC4_ENST00000539845.1_Silent_p.T465T|EXOC4_ENST00000545148.1_Silent_p.T176T|EXOC4_ENST00000460346.1_3'UTR	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	566					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				ACGCAGACACCATGAAGGTGC	0.413000													9	45					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40033909	40033909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40033909G>A	ENST00000373233.3	-	37	7649	c.7472C>T	c.(7471-7473)cCc>cTc	p.P2491L	CHD6_ENST00000480022.1_5'UTR	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2491					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CCCGGTGAGGGGGATGCCTGG	0.562000													8	91					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143027960	143027960	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143027960C>T	ENST00000343257.2	+	8	1036	c.949C>T	c.(949-951)Cga>Tga	p.R317*	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	317			R -> Q (in THD).		muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CTTTGTGTTTCGAGTGCTGGC	0.517000													38	88					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21157582	21157582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21157582G>A	ENST00000255882.6	-	13	1574	c.1488C>T	c.(1486-1488)ttC>ttT	p.F496F	PI4KA_ENST00000572273.1_Silent_p.F438F	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	438					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCACCACCGGGAACCTCTCGC	0.587000													27	67					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138169253	138169253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:138169253G>A	ENST00000409968.1	+	14	2948	c.2770G>A	c.(2770-2772)Gat>Aat	p.D924N	THSD7B_ENST00000272643.3_Missense_Mutation_p.D924N|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.D893N					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATGTCCTTGTGATGAATTTAT	0.453000													48	87					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841626	94841626	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94841626G>A	ENST00000357742.4	+	1	132	c.132G>A	c.(130-132)ttG>ttA	p.L44L	MCTP2_ENST00000543482.1_Silent_p.L44L|MCTP2_ENST00000451018.3_Silent_p.L44L|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	44					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GGCATCACTTGGACCGCCGTC	0.572000													24	107					0	0	1	0	0
NCAPH	23397	broad.mit.edu	37	2	97033013	97033013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97033013C>T	ENST00000455200.1	+	15	2162	c.1867C>T	c.(1867-1869)Cac>Tac	p.H623Y	NCAPH_ENST00000240423.4_Missense_Mutation_p.H634Y|NCAPH_ENST00000427946.1_Missense_Mutation_p.H498Y			Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	634					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(717;0.0221)				AATTGAAATTCACTATGCCAA	0.388000													35	87					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121747930	121747930	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:121747930G>A	ENST00000452319.1	+	14	4500	c.4440G>A	c.(4438-4440)caG>caA	p.Q1480Q	GLI2_ENST00000361492.4_Silent_p.Q1480Q|GLI2_ENST00000314490.11_Intron			P10070	GLI2_HUMAN	GLI family zinc finger 2	1480					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				AGGCCTGTCAGGACAGCATCC	0.632000													34	100					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34002691	34002691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34002691C>T	ENST00000373381.4	-	62	9986	c.9810G>A	c.(9808-9810)ccG>ccA	p.P3270P		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3126						integral to membrane|plasma membrane	protein binding	p.P3126P(1)		NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGTCAGGGTCGGATCTGGAT	0.517000													23	57					0	0	1	0	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727181	25727181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25727181C>T	ENST00000274764.2	+	1	45	c.45C>T	c.(43-45)ggC>ggT	p.G15G		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	15					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						CCAAGAAGGGCTTTAAGAAAG	0.453000													30	77					0	0	1	0	0
GPR114	221188	broad.mit.edu	37	16	57604336	57604336	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57604336C>T	ENST00000340339.4	+	10	1620	c.1097C>T	c.(1096-1098)cCa>cTa	p.P366L	GPR114_ENST00000394361.4_Intron|GPR114_ENST00000349457.3_Missense_Mutation_p.P366L	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	366					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						TCAGGGGCCCCAGCCCTCCTG	0.627000													14	57					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769732	57769732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57769732G>A	ENST00000371030.2	+	1	3658	c.3658G>A	c.(3658-3660)Ggt>Agt	p.G1220S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1220						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CCGAGATGAGGGTCCCAATGG	0.627000													11	19					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204950989	204950989	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204950989G>A	ENST00000367172.4	+	21	2639	c.2311G>A	c.(2311-2313)Gag>Aag	p.E771K	NFASC_ENST00000404076.1_Missense_Mutation_p.E750K|NFASC_ENST00000513543.1_Missense_Mutation_p.E767K|NFASC_ENST00000367171.4_Missense_Mutation_p.E756K|NFASC_ENST00000339876.6_Missense_Mutation_p.E771K|NFASC_ENST00000539706.1_Missense_Mutation_p.E767K|NFASC_ENST00000404907.1_Missense_Mutation_p.E767K|NFASC_ENST00000360049.4_Missense_Mutation_p.E767K|NFASC_ENST00000367170.4_Missense_Mutation_p.E771K|NFASC_ENST00000401399.1_Missense_Mutation_p.E771K|NFASC_ENST00000367169.4_Missense_Mutation_p.E771K|NFASC_ENST00000338586.6_Missense_Mutation_p.E771K|NFASC_ENST00000338515.6_Missense_Mutation_p.E771K			O94856	NFASC_HUMAN	neurofascin	771	Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GAGGCGGAGAGAGACTCGAGA	0.622000													18	53					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65141095	65141095	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:65141095G>A	ENST00000371073.2	+	20	2739	c.2739G>A	c.(2737-2739)acG>acA	p.T913T	CACHD1_ENST00000290039.5_Silent_p.T862T|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	913					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GGGATTTGACGAACCTTGTGC	0.468000											OREG0013544	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	73					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6750959	6750959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6750959C>T	ENST00000378827.4	+	2	1405	c.186C>T	c.(184-186)ggC>ggT	p.G62G		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	62					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GCATGTTCGGCCTGAAACAGA	0.682000													7	27					0	0	1	0	0
LOC647264	647264	broad.mit.edu	37	13	64321066	64321066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:64321066G>A	ENST00000453638.2	+	1	133	c.133G>A	c.(133-135)Ggc>Agc	p.G45S																	endometrium(2)|lung(1)|urinary_tract(1)	4						ctgtggctatggctgtggcta	0.557000													11	29					0	0	1	0	0
AZU1	566	broad.mit.edu	37	19	828354	828354	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:828354C>T	ENST00000233997.2	+	2	204	c.183C>T	c.(181-183)ttC>ttT	p.F61F		NM_001700.3	NP_001691.1	P20160	CAP7_HUMAN	azurocidin 1	61	Hydrophobic.|Peptidase S1.|Possesses antibiotic activity.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			NS(1)|endometrium(1)|kidney(1)|lung(4)|pancreas(1)|upper_aerodigestive_tract(2)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGCCCGCTTCGTGATGACCG	0.672000													17	82					0	0	1	0	0
HBG2	3048	broad.mit.edu	37	11	5275656	5275656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5275656C>T	ENST00000380259.2	-	7	1421	c.181G>A	c.(181-183)Gtc>Atc	p.V61I	HBG2_ENST00000336906.4_Missense_Mutation_p.V61I|HBG2_ENST00000380252.1_Missense_Mutation_p.V51I					hemoglobin, gamma G											endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	13		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTGCCTTGACTTTGGGGTTG	0.537000													27	102					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117232173	117232173	+	Missense_Mutation	SNP	C	C	T	rs143723757		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117232173C>T	ENST00000332958.2	+	7	764	c.748C>T	c.(748-750)Ctt>Ttt	p.L250F	RFX6_ENST00000471966.1_3'UTR	NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	250					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						CGCTCAACACCTTGTATACCA	0.373000													28	82					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62658387	62658387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62658387C>T	ENST00000535781.1	+	15	2072	c.1961C>T	c.(1960-1962)gCc>gTc	p.A654V	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	694					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					ATCAGGGCAGCCCAAGATCTG	0.572000													27	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179393620	179393620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179393620C>T	ENST00000589042.1	-	360	107082	c.106858G>A	c.(106858-106860)Gaa>Aaa	p.E35620K	TTN_ENST00000342992.6_Missense_Mutation_p.E33052K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E26555K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E26747K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E26680K|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000587944.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E33979K|TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000589434.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	33979							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTGACCTTCGTTTATGCTC	0.418000													22	47					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497306	1497306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1497306C>T	ENST00000421627.2	+	2	581	c.447C>T	c.(445-447)atC>atT	p.I149I		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	228					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CCGGGCGGATCCGCCACCTGG	0.687000													3	10					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206166389	206166389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206166389G>A	ENST00000406610.2	+	18	2801	c.2594G>A	c.(2593-2595)aGg>aAg	p.R865K	PARD3B_ENST00000349953.3_Missense_Mutation_p.R865K|PARD3B_ENST00000351153.1_Missense_Mutation_p.R796K|PARD3B_ENST00000358768.2_Missense_Mutation_p.R803K|PARD3B_ENST00000462231.1_Missense_Mutation_p.R865K	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	865	Lys-rich.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		gatccagaaaggaaaataaag	0.418000													12	29					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65811104	65811104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65811104G>A	ENST00000312006.4	-	3	451	c.170C>T	c.(169-171)tCg>tTg	p.S57L	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.S57L	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	57					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GCGCGGCGGCGAGTTCCGCAG	0.652000													12	33					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1893043	1893043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1893043C>T	ENST00000399161.2	-	16	3237	c.2490G>A	c.(2488-2490)agG>agA	p.R830R	MYT1L_ENST00000428368.2_Silent_p.R828R	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	830					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CCTCGTCTATCCTCCGGGGTT	0.537000													24	72					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20525740	20525740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20525740C>T	ENST00000504154.1	+	14	1630	c.1378C>T	c.(1378-1380)Ccc>Tcc	p.P460S	SLIT2_ENST00000273739.5_Missense_Mutation_p.P464S|SLIT2_ENST00000503823.1_Missense_Mutation_p.P460S|SLIT2_ENST00000503837.1_Missense_Mutation_p.P464S	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	460	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TTGCACCAGCCCCCGCCGCCT	0.488000													47	198					0	0	1	0	0
FAAH	2166	broad.mit.edu	37	1	46871292	46871292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46871292C>T	ENST00000243167.8	+	5	695	c.611C>T	c.(610-612)aCc>aTc	p.T204I	FAAH_ENST00000493735.1_3'UTR	NM_001441.2	NP_001432.2	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	204					fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	22	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	TTTGGCCAGACCGTGAACCCA	0.662000													46	171					0	0	1	0	0
FBLIM1	54751	broad.mit.edu	37	1	16091602	16091602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16091602C>T	ENST00000375766.3	+	3	764	c.124C>T	c.(124-126)Ccc>Tcc	p.P42S	FBLIM1_ENST00000375771.1_Missense_Mutation_p.P42S|FBLIM1_ENST00000332305.5_Missense_Mutation_p.P42S|FBLIM1_ENST00000441801.2_Missense_Mutation_p.P42S|FBLIM1_ENST00000400773.1_Missense_Mutation_p.P42S	NM_017556.2	NP_060026.2	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	42	Filamin-binding.|Pro-rich.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		GCGTGGCCGCCCCTGGGAGGC	0.706000													25	51					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31355448	31355448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:31355448G>A	ENST00000542188.1	-	7	1202	c.889C>T	c.(889-891)Cct>Tct	p.P297S	TRPM1_ENST00000256552.6_Missense_Mutation_p.P280S|TRPM1_ENST00000397795.2_Missense_Mutation_p.P258S	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	258					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		ACCACGTTAGGGCCCCCCTCC	0.612000													41	108					0	0	1	0	0
ADAM33	80332	broad.mit.edu	37	20	3654066	3654066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3654066G>A	ENST00000356518.2	-	11	1309	c.1068C>T	c.(1066-1068)gaC>gaT	p.D356D	ADAM33_ENST00000466620.1_5'UTR|ADAM33_ENST00000379861.4_Silent_p.D356D|ADAM33_ENST00000350009.2_Silent_p.D356D	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	356	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						AGCCGTCGGGGTCGTGGCTGA	0.766000													5	5					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104312939	104312939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104312939C>T	ENST00000389120.3	+	10	1234	c.1144C>T	c.(1144-1146)Cgc>Tgc	p.R382C		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	382					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		TCCAGAATATCGCTGCATGCA	0.507000													83	124					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85566375	85566375	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85566375G>A	ENST00000295887.5	+	12	1576	c.1152_splice	c.e12-1	p.D385_splice		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	385					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GTTTCTAAAGGATTTTGCAAA	0.338000													23	63					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039377	11039377	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039377C>T	ENST00000470054.1	-	0	826									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAGACATTTTCATTTCTTCAC	0.338000													28	311					0	0	1	0	0
RRH	10692	broad.mit.edu	37	4	110763652	110763652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110763652C>T	ENST00000317735.4	+	6	782	c.748C>T	c.(748-750)Ctg>Ttg	p.L250L		NM_006583.2	NP_006574.1	O14718	OPSX_HUMAN	retinal pigment epithelium-derived rhodopsin homolog	250					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	12		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		CTGCATGTTTCTGGTGGCATG	0.398000													39	135					0	0	1	0	0
CYBRD1	79901	broad.mit.edu	37	2	172409859	172409859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:172409859C>T	ENST00000321348.4	+	3	604	c.406C>T	c.(406-408)Ctt>Ttt	p.L136F	CYBRD1_ENST00000409484.1_Missense_Mutation_p.L78F|CYBRD1_ENST00000375252.3_Missense_Mutation_p.S66F	NM_024843.3	NP_079119.3	Q53TN4	CYBR1_HUMAN	cytochrome b reductase 1	136	Cytochrome b561.				cellular iron ion homeostasis|electron transport chain|transmembrane transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|liver(2)|lung(3)	10						TGTTTAGCTTCTTTCAGGTTT	0.328000													22	70					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904769	55904769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55904769G>A	ENST00000301529.1	-	1	425	c.426C>T	c.(424-426)ctC>ctT	p.L142L		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					ACACCAGCAGGAGGCAGAGCC	0.473000													25	108					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579753	44579753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44579753G>A	ENST00000289547.4	-	2	298	c.243C>T	c.(241-243)ctC>ctT	p.L81L	NPC1L1_ENST00000423141.1_Silent_p.L81L|NPC1L1_ENST00000381160.3_Silent_p.L81L|NPC1L1_ENST00000546276.1_Silent_p.L81L	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	81					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GGCCGGTGTAGAGGCGGGGGC	0.612000													12	31					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116758449	116758449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116758449C>T	ENST00000331677.3	+	7	3262	c.2818C>T	c.(2818-2820)Ctc>Ttc	p.L940F	DSE_ENST00000359564.2_Missense_Mutation_p.L940F|DSE_ENST00000537543.1_Missense_Mutation_p.L959F|DSE_ENST00000452085.3_Missense_Mutation_p.L940F			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	940					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TGCAGTTCTTCTCATAGATAG	0.388000													18	56					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21251345	21251345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21251345G>A	ENST00000233242.1	-	13	1810	c.1683C>T	c.(1681-1683)gcC>gcT	p.A561A	APOB_ENST00000399256.4_Silent_p.A561A	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	561	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACATAAGATAGGCAGCCAGTC	0.443000													23	130					0	0	1	0	0
SNX15	29907	broad.mit.edu	37	11	64803081	64803081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64803081C>T	ENST00000377244.3	+	6	740	c.610C>T	c.(610-612)Cga>Tga	p.R204*	SNX15_ENST00000301886.3_3'UTR	NM_013306.4|NM_147777.3	NP_037438.2|NP_680086.2	Q9NRS6	SNX15_HUMAN	sorting nexin 15	204					cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14						TTCCCCTGCCCGAGGCCCCCT	0.637000													54	147					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24581180	24581180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24581180C>T	ENST00000535378.1	-	8	1868	c.1226G>A	c.(1225-1227)gGa>gAa	p.G409E	KIAA0319_ENST00000378214.3_Missense_Mutation_p.G418E|KIAA0319_ENST00000430948.2_Missense_Mutation_p.G373E|KIAA0319_ENST00000543707.1_Missense_Mutation_p.G418E|KIAA0319_ENST00000537886.1_Missense_Mutation_p.G418E	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	418	PKD 1.				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						ATTGACAAATCCTTCTCCAAA	0.393000											OREG0017229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	139					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117243663	117243663	+	Missense_Mutation	SNP	C	C	T	rs121909034	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117243663C>T	ENST00000003084.6	+	17	2867	c.2735C>T	c.(2734-2736)tCg>tTg	p.S912L	CFTR_ENST00000454343.1_Missense_Mutation_p.S851L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	912	ABC transmembrane type-1 2.		S -> L.		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AGCACCAGTTCGTATTATGTG	0.418000									Cystic Fibrosis				9	109					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12955431	12955431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12955431C>T	ENST00000235347.4	-	2	327	c.248G>A	c.(247-249)aGg>aAg	p.R83K		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	83										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATCAAGTCCCCTCAGGACAGC	0.612000													17	47					0	0	1	0	0
LYZL4	131375	broad.mit.edu	37	3	42445550	42445550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42445550C>T	ENST00000287748.3	-	4	634	c.359G>A	c.(358-360)gGg>gAg	p.G120E	LYZL4_ENST00000441172.1_Missense_Mutation_p.G120E|LYZL4_ENST00000470991.1_5'UTR	NM_144634.2	NP_653235.1	Q96KX0	LYZL4_HUMAN	lysozyme-like 4	120					cell wall macromolecule catabolic process	extracellular region	lysozyme activity	p.G120V(1)		central_nervous_system(1)|endometrium(1)|lung(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.222)		TGCTCCCATCCCTTCTTTTCC	0.383000													17	47					0	0	1	0	0
NUDT21	11051	broad.mit.edu	37	16	56480599	56480599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56480599G>A	ENST00000300291.5	-	3	492	c.320C>T	c.(319-321)cCt>cTt	p.P107L		NM_007006.2	NP_008937.1	O43809	CPSF5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 21	107	Necessary for RNA-binding.|Necessary for interactions with PAPOLA and PABPN1.|Nudix hydrolase.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	centrosome|mRNA cleavage factor complex|paraspeckles	AU-rich element binding|histone deacetylase binding|hydrolase activity|mRNA binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)	7						TTCACCACCAGGTCTGTATAA	0.318000													9	68					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	109001422	109001422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:109001422C>T	ENST00000276659.5	-	3	765	c.145G>A	c.(145-147)Gac>Aac	p.D49N	RSPO2_ENST00000517939.1_5'UTR|RSPO2_ENST00000517781.1_Intron|RSPO2_ENST00000378439.2_Intron	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	49					Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CACCCATTGTCCTTTGAACAA	0.403000													22	55					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121942283	121942283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121942283G>A	ENST00000442488.2	-	4	1263	c.1196C>T	c.(1195-1197)cCt>cTt	p.P399L	FEZF1_ENST00000331178.4_Missense_Mutation_p.P395L|FEZF1_ENST00000427185.2_Missense_Mutation_p.P349L	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	399					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						GCAGGTGAAAGGCTTCTTGTC	0.567000													9	181					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151123530	151123530	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151123530G>A	ENST00000370328.3	-	9	1217	c.1164C>T	c.(1162-1164)gcC>gcT	p.A388A	GABRE_ENST00000370325.1_3'UTR|GABRE_ENST00000483564.1_5'UTR	NM_004961.3	NP_004952.2	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	388					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CACGGGTACGGGCATGGGCAC	0.542000													3	6					0	0	1	0	0
CD276	80381	broad.mit.edu	37	15	73996202	73996202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73996202C>T	ENST00000318443.5	+	5	1238	c.936C>T	c.(934-936)gcC>gcT	p.A312A	CD276_ENST00000318424.5_Intron|CD276_ENST00000537340.2_Silent_p.A166A|CD276_ENST00000561213.1_Silent_p.A312A|CD276_ENST00000564751.1_Intron	NM_001024736.1	NP_001019907.1	Q5ZPR3	CD276_HUMAN	CD276 molecule	312	Ig-like V-type 2.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						ACCGCACGGCCCTCTTCCCGG	0.642000													17	55					0	0	1	0	0
KCNJ14	3770	broad.mit.edu	37	19	48967571	48967571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48967571C>T	ENST00000391884.1	+	2	1324	c.848C>T	c.(847-849)cCt>cTt	p.P283L	KCNJ14_ENST00000342291.2_Missense_Mutation_p.P283L			Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 14	283						voltage-gated potassium channel complex	inward rectifier potassium channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(2)|urinary_tract(1)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		TCTGCCAGTCCTCTGTATGAG	0.577000													7	12					0	0	1	0	0
RBM44	375316	broad.mit.edu	37	2	238725807	238725807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238725807C>T	ENST00000316997.4	+	3	380	c.248C>T	c.(247-249)tCa>tTa	p.S83L	RBM44_ENST00000409864.1_Missense_Mutation_p.S83L|RBM44_ENST00000444524.2_Intron	NM_001080504.2	NP_001073973.2	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	82							nucleotide binding|RNA binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(7)|ovary(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		CCATTTTTTTCAGTGAGTCAA	0.333000													28	61					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286115	48286115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48286115C>T	ENST00000320048.1	+	1	703	c.703C>T	c.(703-705)Ctc>Ttc	p.L235F		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GCACAAGGCCCTCTCCACCTG	0.537000													44	40					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123695634	123695634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:123695634C>T	ENST00000422452.2	-	14	2384	c.2321G>A	c.(2320-2322)cGa>cAa	p.R774Q	TENM1_ENST00000371130.3_Missense_Mutation_p.R774Q	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1									p.R776Q(1)									CAGGGTACATCGTCCATTTCC	0.473000													40	28					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97143773	97143773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97143773G>A	ENST00000371247.2	-	17	1696	c.1507C>T	c.(1507-1509)Cgc>Tgc	p.R503C	SORBS1_ENST00000361941.3_Missense_Mutation_p.R503C|SORBS1_ENST00000393949.1_Missense_Mutation_p.R473C|SORBS1_ENST00000354106.3_Missense_Mutation_p.R473C|SORBS1_ENST00000371245.3_Missense_Mutation_p.R388C|SORBS1_ENST00000371227.4_Missense_Mutation_p.R457C|SORBS1_ENST00000371241.1_Missense_Mutation_p.R293C|SORBS1_ENST00000607232.1_Missense_Mutation_p.R292C|SORBS1_ENST00000306402.6_Missense_Mutation_p.R334C|SORBS1_ENST00000371249.2_Missense_Mutation_p.R425C|SORBS1_ENST00000371239.1_Missense_Mutation_p.R302C|SORBS1_ENST00000347291.4_Missense_Mutation_p.R371C|SORBS1_ENST00000277982.5_Missense_Mutation_p.R525C|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000353505.5_Missense_Mutation_p.R388C|SORBS1_ENST00000371246.2_Missense_Mutation_p.R525C			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	503					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GAGGAAGAGCGGGCTGGGAGG	0.517000													33	87					0	0	1	0	0
ANKRD30BP3	338579	broad.mit.edu	37	10	45652289	45652289	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45652289C>T	ENST00000427229.2	+	0	1803																											CCTGACATGGCTGAAAGCTTG	0.473000													10	34					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69472590	69472590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69472590C>T	ENST00000303714.4	+	18	1990	c.1668C>T	c.(1666-1668)tcC>tcT	p.S556S		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	556	Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						ctcctccctcccgccctcctc	0.622000									Familial Infantile Hemangioma				7	43					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109859092	109859092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109859092C>T	ENST00000356711.2	+	35	5611	c.5485C>T	c.(5485-5487)Cca>Tca	p.P1829S	MYO16_ENST00000357550.2_Missense_Mutation_p.P1829S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1829					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GGTGCCTCCCCCACCACCTTG	0.607000													4	58					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134183896	134183896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:134183896G>A	ENST00000431683.2	+	17	1641	c.1641G>A	c.(1639-1641)ctG>ctA	p.L547L		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	547					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TCTATTCCCTGGAGATGAAAA	0.483000													4	20					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92470044	92470044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92470044C>T	ENST00000370389.2	+	17	3167	c.2243C>T	c.(2242-2244)tCc>tTc	p.S748F	BRDT_ENST00000362005.3_Missense_Mutation_p.S821F|BRDT_ENST00000399546.2_Missense_Mutation_p.S821F|BRDT_ENST00000394530.3_Missense_Mutation_p.S775F|BRDT_ENST00000402388.1_Missense_Mutation_p.S821F	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	821					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GTAATGAAATCCTCAGATGAG	0.358000													43	104					0	0	1	0	0
SLC37A1	54020	broad.mit.edu	37	21	43982259	43982259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43982259C>T	ENST00000352133.2	+	12	2035	c.1053C>T	c.(1051-1053)ccC>ccT	p.P351P	SLC37A1_ENST00000398341.3_Silent_p.P351P			P57057	GLPT_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 1	351					carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						TCTGGCTGCCCCTGTACATCA	0.507000													30	106					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44560656	44560656	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44560656C>T	ENST00000289547.4	-	13	3070	c.3015G>A	c.(3013-3015)gtG>gtA	p.V1005V	NPC1L1_ENST00000381160.3_Silent_p.V1005V|NPC1L1_ENST00000546276.1_Silent_p.V959V	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1005					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GGAACTGCTCCACCGAGGGCC	0.567000													45	163					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563900	176563900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176563900G>A	ENST00000367662.3	+	3	2324	c.1160G>A	c.(1159-1161)aGc>aAc	p.S387N	PAPPA2_ENST00000367661.3_Missense_Mutation_p.S387N	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	387					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CAGGTGGCTAGCAGTCTAGAC	0.577000													25	62					0	0	1	0	0
RHOH	399	broad.mit.edu	37	4	40245409	40245409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40245409G>A	ENST00000381799.4	+	3	1127	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K	RHOH_ENST00000505618.1_Missense_Mutation_p.E135K	NM_001278363.1|NM_001278365.1|NM_004310.3	NP_001265292.1|NP_001265294.1|NP_004301.1	Q15669	RHOH_HUMAN	ras homolog family member H	135					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			kidney(1)|large_intestine(3)|lung(7)|ovary(1)	12						CAATGCCATGGAAGGGAAGAA	0.612000													20	46					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994983	140994983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140994983G>A	ENST00000285879.4	+	4	2079	c.1793G>A	c.(1792-1794)aGc>aAc	p.S598N	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	598							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCTCAGAGCCCTCCTCAG	0.587000										HNSCC(15;0.026)			215	160					0	0	1	0	0
PSKH2	85481	broad.mit.edu	37	8	87076221	87076221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87076221C>T	ENST00000276616.2	-	2	899	c.825G>A	c.(823-825)ctG>ctA	p.L275L		NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	275	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			ATTTGCCTTTCAGAATCTTCC	0.403000													10	42					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206224524	206224524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206224524C>T	ENST00000367126.4	+	1	549	c.84C>T	c.(82-84)ggC>ggT	p.G28G		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	28					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCTGGCTGGGCCGGGATGAGG	0.672000													88	257					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173352339	173352339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:173352339C>T	ENST00000375221.2	+	17	2545	c.2342C>T	c.(2341-2343)cCt>cTt	p.P781L	ITGA6_ENST00000343713.4_Missense_Mutation_p.P737L|ITGA6_ENST00000264106.6_Missense_Mutation_p.P781L|ITGA6_ENST00000409532.1_Missense_Mutation_p.P623L|ITGA6_ENST00000264107.7_Missense_Mutation_p.P742L|ITGA6_ENST00000409080.1_Missense_Mutation_p.P742L|AC093818.1_ENST00000442417.1_RNA			P23229	ITA6_HUMAN	integrin, alpha 6	781					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CTCGGAAATCCTTTTAAAAGA	0.408000													17	57					0	0	1	0	0
HOMER1	9456	broad.mit.edu	37	5	78672008	78672008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78672008G>A	ENST00000334082.6	-	9	2331	c.889C>T	c.(889-891)Cgg>Tgg	p.R297W	HOMER1_ENST00000508576.1_3'UTR|HOMER1_ENST00000282260.6_Missense_Mutation_p.R167W|HOMER1_ENST00000535690.1_Missense_Mutation_p.R123W	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)	297					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		TCTTTGTTCCGAATTTCTACT	0.368000													43	109					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170037998	170037998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170037998C>T	ENST00000263816.3	-	52	10414	c.10129G>A	c.(10129-10131)Gat>Aat	p.D3377N	LRP2_ENST00000461418.1_5'UTR	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3377					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TAGAGTAGATCATTGGTGTAA	0.418000													22	78					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3265542	3265542	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3265542G>A	ENST00000520002.1	-	15	2508	c.1953C>T	c.(1951-1953)gtC>gtT	p.V651V	CSMD1_ENST00000542608.1_Silent_p.V650V|CSMD1_ENST00000539096.1_Silent_p.V650V|CSMD1_ENST00000537824.1_Silent_p.V650V|CSMD1_ENST00000602723.1_Silent_p.V651V|CSMD1_ENST00000400186.3_Silent_p.V651V|CSMD1_ENST00000602557.1_Silent_p.V651V			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	651	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAGTACCCAGGACAGTTATGT	0.463000													5	36					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37744553	37744553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37744553C>T	ENST00000539465.1	+	16	3117	c.2524C>T	c.(2524-2526)Cta>Tta	p.L842L	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Silent_p.L842L			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	842						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		AAGGTCTTTCCTACAGACCGA	0.557000													28	52					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94652133	94652133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94652133G>A	ENST00000260526.6	-	16	1884	c.1702C>T	c.(1702-1704)Cca>Tca	p.P568S	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	568					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GGTGTTCGTGGAAGTTTTCGA	0.373000													68	138					0	0	1	0	0
NXPE4	54827	broad.mit.edu	37	11	114451014	114451014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:114451014G>A	ENST00000375478.3	-	5	1119	c.939C>T	c.(937-939)tcC>tcT	p.S313S	NXPE4_ENST00000424261.2_Silent_p.S29S	NM_001077639.1	NP_001071107.1			neurexophilin and PC-esterase domain family, member 4																		TGGGGATTGTGGATGTCATTC	0.413000													29	94					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103061833	103061833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103061833C>T	ENST00000306312.3	-	3	390	c.129G>A	c.(127-129)gcG>gcA	p.A43A	SLC26A5_ENST00000393723.1_Silent_p.A43A|SLC26A5_ENST00000393727.1_Silent_p.A43A|SLC26A5_ENST00000393729.1_Silent_p.A43A|SLC26A5_ENST00000393730.1_Silent_p.A43A|SLC26A5_ENST00000393735.2_Silent_p.A43A|SLC26A5_ENST00000356767.4_Silent_p.A43A|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000339444.6_Silent_p.A43A|SLC26A5_ENST00000432958.2_Silent_p.A43A	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	43					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						TCAGCTTATCCGCAATGGAAT	0.433000													10	49					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18876381	18876381	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18876381G>A	ENST00000266505.7	-	4	494	c.231C>T	c.(229-231)ttC>ttT	p.F77F	PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000447925.2_Silent_p.F75F|RP11-361I14.2_ENST00000536931.1_RNA|PLCZ1_ENST00000435379.1_Intron			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	77					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AATATGTGTTGAAAATCTCAA	0.348000													23	52					0	0	1	0	0
TXLNB	167838	broad.mit.edu	37	6	139564197	139564197	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:139564197G>A	ENST00000358430.3	-	10	1753	c.1521C>T	c.(1519-1521)ttC>ttT	p.F507F	RP1-225E12.3_ENST00000585874.1_RNA	NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	507						cytoplasm		p.F507F(1)		breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		GAATTATCATGAAGGCTGTGG	0.512000													50	122					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31309784	31309784	+	Silent	SNP	C	C	T	rs11542984	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:31309784C>T	ENST00000380490.3	+	1	140	c.42C>T	c.(40-42)atC>atT	p.I14I		NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	14					cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		TGTTGGCCATCGTCACCCTCA	0.517000													15	38					0	0	1	0	0
TFPI	7035	broad.mit.edu	37	2	188349653	188349653	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:188349653C>T	ENST00000233156.3	-	5	714	c.420G>A	c.(418-420)agG>agA	p.R140R	AC007319.1_ENST00000412276.1_RNA|TFPI_ENST00000339091.4_Silent_p.R140R|AC007319.1_ENST00000453517.1_RNA|TFPI_ENST00000409676.1_Silent_p.R140R|TFPI_ENST00000392365.1_Silent_p.R140R	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	140	BPTI/Kunitz inhibitor 2.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	TATAAAAATACCTGGTAATAT	0.343000													7	63					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11078587	11078587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11078587C>T	ENST00000287766.4	+	16	2156	c.1735C>T	c.(1735-1737)Cgc>Tgc	p.R579C	SLC6A1_ENST00000536032.1_Missense_Mutation_p.R401C	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	579					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	AGACATCGTTCGCCCAGAGAA	0.637000													29	72					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164534538	164534538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164534538C>T	ENST00000503008.1	-	5	1146	c.170G>A	c.(169-171)aGc>aAc	p.S57N	MARCH1_ENST00000514618.1_Missense_Mutation_p.S57N|MARCH1_ENST00000274056.7_Missense_Mutation_p.S57N|MARCH1_ENST00000339875.5_Missense_Mutation_p.S40N	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	57	Responsible for low stability (By similarity).				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGTTGTTGGGCTGCTTGCCTG	0.403000													37	84					0	0	1	0	0
REN	5972	broad.mit.edu	37	1	204124159	204124159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204124159G>A	ENST00000367195.2	-	9	1240	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	REN_ENST00000272190.8_Silent_p.F402F			P00797	RENI_HUMAN	renin	402					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGGCCAAGGCGAAGCCAATGC	0.632000													18	49					0	0	1	0	0
GMCL1	64395	broad.mit.edu	37	2	70096880	70096880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70096880C>T	ENST00000282570.3	+	12	1499	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F		NM_178439.3	NP_848526.1	Q96IK5	GMCL1_HUMAN	germ cell-less, spermatogenesis associated 1	416					cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	15						GTTTTAACTTCGGCTTCGACC	0.358000													22	111					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18691869	18691869	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18691869C>T	ENST00000251296.1	+	6	1076	c.693C>T	c.(691-693)ctC>ctT	p.L231L		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	231						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CACTGTCCCTCCTGGACGCCG	0.652000													40	111					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70635117	70635117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70635117G>A	ENST00000381269.2	-	2	776	c.23C>T	c.(22-24)cCt>cTt	p.P8L	SLC8A3_ENST00000534137.1_Missense_Mutation_p.P8L|SLC8A3_ENST00000528359.1_Missense_Mutation_p.P8L|SLC8A3_ENST00000356921.2_Missense_Mutation_p.P8L|SLC8A3_ENST00000357887.3_Missense_Mutation_p.P8L	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	8					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGAGGTGAGAGGCTGCAACCT	0.537000													14	31					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56370026	56370026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56370026G>A	ENST00000301295.6	+	3	1689	c.1267G>A	c.(1267-1269)Ggg>Agg	p.G423R	NLRP4_ENST00000346986.5_Missense_Mutation_p.G423R|NLRP4_ENST00000587891.1_Missense_Mutation_p.G348R	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	423	NACHT.						ATP binding	p.G423W(2)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCGGAGAAATGGGGTTGTTGA	0.562000													53	99					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124253036	124253036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124253036G>A	ENST00000375013.2	-	1	222	c.204C>T	c.(202-204)ttC>ttT	p.F68F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGAGATCAATGAAGGAGAGAT	0.408000													51	142					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108861132	108861132	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:108861132G>A	ENST00000356922.4	-	2	2757	c.2485C>T	c.(2485-2487)Ctg>Ttg	p.L829L	LIG4_ENST00000442234.1_Silent_p.L829L|LIG4_ENST00000405925.1_Silent_p.L829L	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	829	BRCT 2.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TTGGTACTCAGGTCATTAATA	0.428000								Non-homologous end-joining					18	79					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76492029	76492029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76492029C>T	ENST00000389840.5	-	38	5913	c.5789G>A	c.(5788-5790)gGt>gAt	p.G1930D	DNAH17_ENST00000585328.1_Missense_Mutation_p.G1939D|RP11-559N14.5_ENST00000591373.1_RNA					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GATGAAGATACCGACGGTGGG	0.527000													16	59					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149516467	149516467	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149516467C>T	ENST00000378016.2	+	0	11870							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCGTGGGAACCTTGCTCCCGC	0.701000													4	21					0	0	1	0	0
HOXB1	3211	broad.mit.edu	37	17	46608058	46608058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46608058G>A	ENST00000239174.6	-	1	301	c.209C>T	c.(208-210)tCg>tTg	p.S70L	HOXB1_ENST00000577092.1_Missense_Mutation_p.S70L	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	70						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCCCAGGGTCGAAGGCGGCTG	0.682000													16	47					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43400359	43400359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43400359C>T	ENST00000244533.3	+	1	871	c.512C>T	c.(511-513)gCt>gTt	p.A171V	ABCC10_ENST00000372530.4_Missense_Mutation_p.A214V|ABCC10_ENST00000443426.2_Intron	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	214						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CCTGAGGTGGCTGAAGATGGG	0.637000													41	100					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16411595	16411595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:16411595C>T	ENST00000334133.4	-	6	1290	c.1018G>A	c.(1018-1020)Gga>Aga	p.G340R	RFTN1_ENST00000432519.1_Missense_Mutation_p.G304R|RFTN1_ENST00000483671.1_5'UTR	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	340						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						TTCACTATTCCAAGGTAGAAG	0.493000													24	111					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45960781	45960781	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45960781G>A	ENST00000348697.2	+	15	1862	c.1715G>A	c.(1714-1716)gGa>gAa	p.G572E	FBLN1_ENST00000442170.2_Missense_Mutation_p.G572E|FBLN1_ENST00000327858.6_Intron			P23142	FBLN1_HUMAN	fibulin 1	571	EGF-like 9; calcium-binding.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TCCAAGAAGGGAAGGCAGAAC	0.527000													6	76					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177063141	177063141	+	Nonsense_Mutation	SNP	C	C	T	rs142589281		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:177063141C>T	ENST00000393643.2	+	11	1702	c.1450C>T	c.(1450-1452)Cga>Tga	p.R484*	WDR17_ENST00000280190.4_Nonsense_Mutation_p.R508*|WDR17_ENST00000508596.1_Nonsense_Mutation_p.R484*|WDR17_ENST00000507824.2_Nonsense_Mutation_p.R491*	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	508										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TAGTATTATTCGAACAATTGA	0.274000													44	89					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917519	48917519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48917519G>A	ENST00000311378.4	+	2	1398	c.870G>A	c.(868-870)cgG>cgA	p.R290R	RP11-506D12.5_ENST00000572491.2_RNA|WFIKKN2_ENST00000426127.1_Silent_p.R197R	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	290	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCACGGCCCGGAACGTGGCTG	0.622000													19	56					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2017126	2017126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2017126G>A	ENST00000382722.5	-	5	926	c.564C>T	c.(562-564)ctC>ctT	p.L188L	CACNA2D4_ENST00000586184.1_Silent_p.L188L|CACNA2D4_ENST00000585732.1_Silent_p.L188L|CACNA2D4_ENST00000585708.1_Silent_p.L124L|CACNA2D4_ENST00000587995.1_Silent_p.L188L|CACNA2D4_ENST00000588077.1_Silent_p.L124L	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	188						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TGGACTCCAGGAGGAACTCGG	0.597000													8	36					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645340	52645340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:52645340C>T	ENST00000395961.3	-	4	480	c.314G>A	c.(313-315)gGa>gAa	p.G105E	BCAS1_ENST00000371440.3_Missense_Mutation_p.G105E|BCAS1_ENST00000371435.2_Missense_Mutation_p.G105E|BCAS1_ENST00000411563.1_Missense_Mutation_p.G8E	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	105						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TCCGGTACGTCCTGGTACAGG	0.522000													10	53					0	0	1	0	0
COLEC12	81035	broad.mit.edu	37	18	480750	480750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:480750G>A	ENST00000400256.3	-	2	222	c.15C>T	c.(13-15)ttC>ttT	p.F5F		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	5					carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CCTCCTCTGCGAAGTCGTCTG	0.552000													23	81					0	0	1	0	0
JMJD6	23210	broad.mit.edu	37	17	74720088	74720088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74720088G>A	ENST00000445478.2	-	3	774	c.571C>T	c.(571-573)Ctg>Ttg	p.L191L	JMJD6_ENST00000585429.1_Silent_p.L191L|JMJD6_ENST00000397625.4_Silent_p.L191L	NM_001081461.1	NP_001074930.1	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6	191	JmjC.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			endometrium(2)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|skin(2)	16						CTGGTTCCCAGAGGGTCGATG	0.527000													34	115					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158490620	158490620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:158490620C>T	ENST00000355585.4	+	14	1930	c.1855C>T	c.(1855-1857)Cat>Tat	p.H619Y	SYNJ2_ENST00000367122.2_Missense_Mutation_p.H619Y|SYNJ2_ENST00000367121.3_Missense_Mutation_p.H619Y	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	619							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CTCACGCTCTCATAGATACAT	0.453000													26	27					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663071	22663071	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22663071C>T	ENST00000426066.1	+	0	510					NR_027293.1																						GCCTGATTTTCGGATAGCTGC	0.303000													5	22					0	0	1	0	0
ADAM33	80332	broad.mit.edu	37	20	3655674	3655674	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3655674C>T	ENST00000356518.2	-	4	574	c.333_splice	c.e4+1	p.T111_splice	ADAM33_ENST00000379861.4_Splice_Site_p.T111_splice|ADAM33_ENST00000350009.2_Splice_Site_p.T111_splice	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	111					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						AGCATCTCACCGTGTGGTTGG	0.622000													6	34					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28409123	28409123	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28409123C>T	ENST00000337532.5	-	11	1163	c.887_splice	c.e11+1	p.R296_splice	MPP7_ENST00000540098.1_Splice_Site_p.R296_splice|MPP7_ENST00000375719.3_Splice_Site_p.R296_splice|MPP7_ENST00000445954.2_Splice_Site_p.R171_splice|MPP7_ENST00000375732.1_Splice_Site_p.R296_splice	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	296	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						AGCAGCTCACCTTTCCTGGAA	0.443000													15	65					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14772190	14772190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14772190C>T	ENST00000261170.3	-	24	2966	c.2830G>A	c.(2830-2832)Gga>Aga	p.G944R	RP11-695J4.2_ENST00000545424.1_RNA|RP11-695J4.2_ENST00000542401.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	944	Guanylate cyclase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						ACCGTATCTCCAAATAGACAA	0.478000													27	69					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30365209	30365209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:30365209G>A	ENST00000389194.2	-	1	61	c.56C>T	c.(55-57)tCt>tTt	p.S19F	LTN1_ENST00000389195.2_Missense_Mutation_p.S19F|LTN1_ENST00000361371.4_5'UTR			O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	0							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						GGCGGCGGAAGAGGACACCCT	0.632000													6	9					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3757657	3757657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:3757657C>T	ENST00000252322.1	-	11	1637	c.1169G>A	c.(1168-1170)gGg>gAg	p.G390E	EFCAB4B_ENST00000444507.1_Intron|EFCAB4B_ENST00000440314.2_Intron	NM_032680.3	NP_116069.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	390					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TCCTTCCGACCCCAGGCTTCT	0.592000													16	47					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284411	52284411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52284411C>T	ENST00000301190.6	+	5	908	c.681C>T	c.(679-681)gcC>gcT	p.A227A	ANKRD33_ENST00000538991.1_Silent_p.A33A|ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Silent_p.A102A	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	102										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GCAAGACGGCCCTGGAATGGG	0.622000													8	27					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134158754	134158754	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:134158754G>A	ENST00000389887.5	+	7	3195	c.699G>A	c.(697-699)aaG>aaA	p.K233K	GLB1L3_ENST00000431683.2_Silent_p.K233K			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	233					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CATTCAATAAGGATAAAACAT	0.498000													3	24					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170805230	170805230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170805230G>A	ENST00000436636.2	-	24	3131	c.2787C>T	c.(2785-2787)ctC>ctT	p.L929L	TNIK_ENST00000460047.1_Silent_p.L866L|TNIK_ENST00000538048.1_Silent_p.L881L|TNIK_ENST00000369326.5_Silent_p.L907L|TNIK_ENST00000284483.8_Silent_p.L921L|TNIK_ENST00000470834.1_Silent_p.L892L|TNIK_ENST00000357327.5_Silent_p.L900L|TNIK_ENST00000488470.1_Silent_p.L874L|TNIK_ENST00000475336.1_Silent_p.L837L|TNIK_ENST00000341852.6_Silent_p.L845L	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	929	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CCAGGTCAGGGAGGTTGATGT	0.592000													26	83					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54185403	54185403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54185403G>A	ENST00000259782.4	+	2	478	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	TINAG_ENST00000370864.3_Missense_Mutation_p.E110K|TINAG_ENST00000370869.3_Missense_Mutation_p.E124K|TINAG_ENST00000486436.1_3'UTR	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	128					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TCAACATTATGAAGAGGGATC	0.303000													31	109					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15677785	15677785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15677785C>T	ENST00000281171.4	+	11	2259	c.1929C>T	c.(1927-1929)ttC>ttT	p.F643F	PTPRO_ENST00000348962.2_Silent_p.F643F	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	643	Fibronectin type-III 7.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TGGAATATTTCAACAGTCTGT	0.408000													27	68					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8665652	8665652	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:8665652G>A	ENST00000378641.3	+	10	1411	c.936G>A	c.(934-936)ctG>ctA	p.L312L	PLCB1_ENST00000378637.2_Silent_p.L312L|PLCB1_ENST00000338037.6_Silent_p.L312L	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	312					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CTGAGAAACTGGATTTGAATG	0.413000													72	153					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733833	50733833	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50733833A>T	ENST00000300589.2	+	2	613	c.508A>T	c.(508-510)Atc>Ttc	p.I170F	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	170	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				ATGTGATGAAATCAGGTTGCC	0.552000													8	45					0	0	1	0	0
GRWD1	83743	broad.mit.edu	37	19	48953984	48953984	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48953984C>T	ENST00000253237.5	+	5	977	c.744C>T	c.(742-744)ggC>ggT	p.G248G		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	248						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		CGGACGGCGGCTCCTGGCACG	0.637000													12	25					0	0	1	0	0
GNAZ	2781	broad.mit.edu	37	22	23438219	23438219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23438219C>T	ENST00000248996.4	+	2	1003	c.337C>T	c.(337-339)Ccc>Tcc	p.P113S	RTDR1_ENST00000216036.4_Intron	NM_002073.2	NP_002064.1	P19086	GNAZ_HUMAN	guanine nucleotide binding protein (G protein), alpha z polypeptide	113						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(5)|urinary_tract(1)	19	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		GCTGACGGGCCCCGCTGAGAG	0.692000													38	122					0	0	1	0	0
WISP1	8840	broad.mit.edu	37	8	134232995	134232995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134232995G>A	ENST00000250160.6	+	3	627	c.521G>A	c.(520-522)aGc>aAc	p.S174N	WISP1_ENST00000377863.2_Intron|WISP1_ENST00000519433.1_Intron|WISP1_ENST00000220856.6_Intron|WISP1_ENST00000517423.1_Intron	NM_003882.3	NP_003873.1	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	174	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CGGCGCGTGAGCATACCTGGC	0.677000													17	52					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78440509	78440509	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78440509G>A	ENST00000278550.7	-	22	3780	c.3318C>T	c.(3316-3318)ttC>ttT	p.F1106F		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GGGCTGCAGCGAACCACTTCC	0.557000													6	9					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255485	15255485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15255485G>A	ENST00000378116.4	-	8	2108	c.2102C>T	c.(2101-2103)cCg>cTg	p.P701L		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	701						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GTGCGGAAGCGGCTTCCCACC	0.577000													31	84					0	0	1	0	0
AVIL	10677	broad.mit.edu	37	12	58197165	58197165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58197165C>T	ENST00000537081.1	-	15	1805	c.1806G>A	c.(1804-1806)caG>caA	p.Q602Q	TSFM_ENST00000548851.1_Intron|AVIL_ENST00000257861.3_Silent_p.Q609Q|AVIL_ENST00000550083.1_5'UTR			O75366	AVIL_HUMAN	advillin	609	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CTAGGATTTCCTGCTGAAGTC	0.438000											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	66	125					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53201524	53201524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53201524C>T	ENST00000293774.4	-	7	1742	c.1472G>A	c.(1471-1473)cGa>cAa	p.R491Q	KRT4_ENST00000458244.2_Missense_Mutation_p.R397Q|KRT4_ENST00000551956.1_Missense_Mutation_p.R417Q			B4DRS2	B4DRS2_HUMAN	keratin 4	417						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						ACGCAGCATTCGTGCCAGCTC	0.597000													62	87					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131487353	131487353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:131487353G>A	ENST00000376682.4	+	1	310	c.55G>A	c.(55-57)Gat>Aat	p.D19N	GPR133_ENST00000261654.5_Intron|GPR133_ENST00000535015.1_Intron			Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	0					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ACCTGGGGGCGATCAGCCCCT	0.642000													6	19					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4231306	4231306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4231306C>T	ENST00000221847.5	+	2	239	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	62	Fibronectin type-III 1.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGTGTCCTTCATTGCCACGT	0.652000													12	20					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135447811	135447811	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135447811G>A	ENST00000343036.2	+	7	925	c.877G>A	c.(877-879)Gat>Aat	p.D293N	C9orf171_ENST00000393216.2_Missense_Mutation_p.D257N	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	293										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						CACGGAGGCCGATCGCCAGAG	0.622000													34	57					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10077378	10077378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10077378G>A	ENST00000264828.3	-	63	4588	c.4503C>T	c.(4501-4503)ttC>ttT	p.F1501F		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1501					collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGACTGGGACGAAGCGCCGGC	0.706000													2	1					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087792	47087792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:47087792G>A	ENST00000374312.1	+	3	1428	c.1009G>A	c.(1009-1011)Gtg>Atg	p.V337M	NPY4R_ENST00000395716.1_Missense_Mutation_p.V337M	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		CAAGGCCCTGGTGCTGACTTG	0.562000													18	120					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196723513	196723513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196723513C>T	ENST00000312428.6	-	43	7852	c.7752G>A	c.(7750-7752)atG>atA	p.M2584I		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2584	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATCTCTTTTTCATTTTCATTA	0.368000													38	118					0	0	1	0	0
DDB2	1643	broad.mit.edu	37	11	47256474	47256474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47256474C>T	ENST00000256996.4	+	6	1064	c.869C>T	c.(868-870)cCt>cTt	p.P290L	DDB2_ENST00000378600.3_Intron|DDB2_ENST00000378601.3_Intron|DDB2_ENST00000378603.3_Missense_Mutation_p.P226L	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	290					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						CACAGGCATCCTGTCAACGCA	0.562000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				16	17					0	0	1	0	0
QSOX1	5768	broad.mit.edu	37	1	180166062	180166062	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:180166062C>A	ENST00000367602.3	+	12	2208	c.2134C>A	c.(2134-2136)Ctc>Atc	p.L712I	QSOX1_ENST00000367600.5_Intron			O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1	712					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						GGACATCAGCCTCTGTGTGGG	0.647000													22	42					1.64293e-13	1.65132e-13	1	1	0
CEP128	145508	broad.mit.edu	37	14	81251861	81251861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81251861G>A	ENST00000555265.1	-	15	1964	c.1589C>T	c.(1588-1590)aCc>aTc	p.T530I	CEP128_ENST00000281129.3_Missense_Mutation_p.T530I			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	530						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						ATACAGCTGGGTTTTCAATTC	0.368000													5	15					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55421032	55421032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55421032C>T	ENST00000242994.3	+	2	1187	c.809C>T	c.(808-810)tCt>tTt	p.S270F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	270					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						CAAGATGGGTCTCCTGACCTA	0.522000													50	172					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71532512	71532512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71532512C>T	ENST00000265382.3	+	9	1125	c.820C>T	c.(820-822)Cat>Tat	p.H274Y	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.H274Y	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	274	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		GTTGGGAATTCATTTCCTGGA	0.473000													99	295					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57598915	57598915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57598915C>T	ENST00000243077.3	+	73	11684	c.11218C>T	c.(11218-11220)Cac>Tac	p.H3740Y		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3740	LDL-receptor class A 31.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCACACCACCCACTGCAAAGA	0.612000													23	66					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37602897	37602897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37602897G>A	ENST00000328544.3	-	2	1479	c.946C>T	c.(946-948)Ctc>Ttc	p.L316F	SSTR3_ENST00000402501.1_Missense_Mutation_p.L316F	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	316					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						CGGTAGGAGAGGAAGCCATAA	0.657000													29	75					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106918708	106918708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106918708G>A	ENST00000369701.3	+	11	1915	c.1688G>A	c.(1687-1689)aGa>aAa	p.R563K		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	563						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCCTCAGGAAGAATCTCTAGC	0.418000													36	65					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233297093	233297093	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233297093C>T	ENST00000258229.8	-	18	3524	c.3290G>A	c.(3289-3291)tGg>tAg	p.W1097*	PCNXL2_ENST00000488780.2_Nonsense_Mutation_p.W230*	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1097						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GATGAGATCCCATTTTAAGAC	0.473000													5	23					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8518118	8518118	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8518118G>A	ENST00000381196.4	-	18	1816	c.1273C>T	c.(1273-1275)Cag>Tag	p.Q425*	PTPRD_ENST00000358503.5_Nonsense_Mutation_p.Q412*|PTPRD_ENST00000397611.3_Nonsense_Mutation_p.Q422*|PTPRD_ENST00000356435.5_Nonsense_Mutation_p.Q425*|PTPRD_ENST00000397617.3_Nonsense_Mutation_p.Q415*|PTPRD_ENST00000397606.3_Nonsense_Mutation_p.Q415*|PTPRD_ENST00000540109.1_Nonsense_Mutation_p.Q425*|PTPRD_ENST00000360074.4_Nonsense_Mutation_p.Q412*|PTPRD_ENST00000486161.1_Nonsense_Mutation_p.Q425*|PTPRD_ENST00000537002.1_Nonsense_Mutation_p.Q422*|PTPRD_ENST00000355233.5_Nonsense_Mutation_p.Q425*	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	425	Fibronectin type-III 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATTCGTGCCTGGACATCCCTC	0.502000										TSP Lung(15;0.13)			55	93					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155508777	155508777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155508777C>T	ENST00000302053.3	-	4	475	c.397G>A	c.(397-399)Gat>Aat	p.D133N	FGA_ENST00000403106.3_Missense_Mutation_p.D133N	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	133					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CTTCTCAGATCCTCTGACACT	0.393000													30	87					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348709	140348709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348709C>T	ENST00000289269.5	+	1	2890	c.2358C>T	c.(2356-2358)tcC>tcT	p.S786S	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		786					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAATGGCTCCCTCACCAAGA	0.512000													20	54					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145109544	145109544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145109544G>A	ENST00000426825.1	-	19	2687	c.2606C>T	c.(2605-2607)cCc>cTc	p.P869L	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	869							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GGTGGAGTGGGGGGGCATGGA	0.642000													6	38					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11052823	11052823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11052823G>A	ENST00000295082.1	+	1	761	c.271G>A	c.(271-273)Gag>Aag	p.E91K		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	91						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GTGTGTCATCGAGGTGTACTA	0.562000													19	40					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122774533	122774533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122774533G>A	ENST00000194130.2	-	8	902	c.863C>T	c.(862-864)tCc>tTc	p.S288F	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	288						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	AGCTGGGAAGGAAAACGTAAA	0.433000													21	58					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45295117	45295117	+	Missense_Mutation	SNP	G	G	A	rs56126236		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:45295117G>A	ENST00000447098.2	-	9	1183	c.1172C>T	c.(1171-1173)tCt>tTt	p.S391F	PTCH2_ENST00000372192.3_Missense_Mutation_p.S391F	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	391					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					ACTGACTTCAGAGAACGCATG	0.622000									Basal Cell Nevus syndrome				36	100					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108006601	108006601	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108006601G>A	ENST00000280758.5	+	6	2382	c.1854G>A	c.(1852-1854)gcG>gcA	p.A618A	BTBD11_ENST00000357167.4_Silent_p.A155A|RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000420571.2_Silent_p.A618A|BTBD11_ENST00000490090.2_Silent_p.A618A	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	618						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GGGACGAGGCGATGGTTCAGA	0.602000													7	22					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65264471	65264471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65264471C>T	ENST00000389722.3	-	9	1211	c.1158G>A	c.(1156-1158)ggG>ggA	p.G386G	SPTB_ENST00000389720.3_Silent_p.G386G|SPTB_ENST00000389721.5_Silent_p.G386G|SPTB_ENST00000556626.1_Silent_p.G386G|SPTB_ENST00000542895.1_Silent_p.G386G	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	386					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		ACACTAGTTTCCCATCGTGGG	0.443000													38	147					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66873806	66873806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66873806C>T	ENST00000269080.2	-	31	4070	c.3933G>A	c.(3931-3933)ggG>ggA	p.G1311G	ABCA8_ENST00000586539.1_Silent_p.G1351G|ABCA8_ENST00000430352.2_Silent_p.G1351G	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1311	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					CTCCACCGCTCCCTTTCAGTA	0.557000													31	90					0	0	1	0	0
CCDC172	374355	broad.mit.edu	37	10	118084563	118084563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118084563G>A	ENST00000333254.3	+	2	291	c.40G>A	c.(40-42)Gag>Aag	p.E14K	CCDC172_ENST00000497093.1_3'UTR	NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		CATCTTCACCGAGCATCAGGC	0.522000													21	70					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588020	247588020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247588020G>A	ENST00000366497.2	+	4	2055	c.1275G>A	c.(1273-1275)caG>caA	p.Q425Q	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Silent_p.Q425Q|NLRP3_ENST00000336119.3_Silent_p.Q425Q|NLRP3_ENST00000348069.2_Silent_p.Q425Q|NLRP3_ENST00000391828.3_Silent_p.Q425Q|NLRP3_ENST00000391827.2_Silent_p.Q425Q	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	425	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGAAACAGCAGATGGAGAGTG	0.587000													24	59					0	0	1	0	0
ASB14	142686	broad.mit.edu	37	3	57312513	57312513	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:57312513C>T	ENST00000487349.1	-	8	1443	c.1323G>A	c.(1321-1323)ctG>ctA	p.L441L	ASB14_ENST00000389601.3_Silent_p.L441L	NM_001142733.2|NM_130387.5	NP_001136205.2|NP_569058.1	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box containing 14	441					intracellular signal transduction					central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		ACCCATAGTTCAGCAGCATCC	0.438000													38	118					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113520119	113520119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113520119G>A	ENST00000284601.3	-	4	1096	c.1028C>T	c.(1027-1029)tCa>tTa	p.S343L		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	343					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TGGATCTGTTGAAAATGTATT	0.353000													50	142					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86905850	86905850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86905850G>A	ENST00000370565.4	+	8	1385	c.1223G>A	c.(1222-1224)gGa>gAa	p.G408E		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	408	VWFA.				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AAACTGAATGGAAAAGCTTAT	0.393000													51	139					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196053	207196053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207196053C>T	ENST00000359470.5	-	4	1305	c.1056G>A	c.(1054-1056)gaG>gaA	p.E352E	C1orf116_ENST00000461135.2_Silent_p.E106E	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	352						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					GCCCCAGCTTCTCTAGAGCTT	0.572000													13	89					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111096	55111096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55111096C>T	ENST00000314721.2	+	1	470	c.420C>T	c.(418-420)atC>atT	p.I140I		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						TGGTTTGCATCCTTCTGTTGG	0.468000													59	122					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177250629	177250629	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177250629C>T	ENST00000361539.4	+	8	2629	c.2317C>T	c.(2317-2319)Cct>Tct	p.P773S	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		773						extracellular region		p.P773A(1)		breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						GCTGCCAAACCCTGTGGAATA	0.532000													26	87					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29142318	29142318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29142318G>A	ENST00000377167.2	+	1	1008	c.906G>A	c.(904-906)gcG>gcA	p.A302A		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						AAGGGGCAGCGAAGAGACTAT	0.453000													18	71					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106526580	106526580	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:106526580G>A	ENST00000359195.3	+	10	3183	c.2872_splice	c.e10-1	p.G958_splice	PIK3CG_ENST00000496166.1_Splice_Site_p.G958_splice|PIK3CG_ENST00000440650.2_Splice_Site_p.G958_splice	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	958	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						TTCTCTTAAGGAAACCTATTT	0.373000													13	45					0	0	1	0	0
IGHV2-5	28457	broad.mit.edu	37	14	106494237	106494237	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106494237C>T	ENST00000390597.2	-	0	274																											TGAGCCTGCTCTTCAGAGATG	0.532000													15	96					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183096487	183096487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183096487C>T	ENST00000258341.4	+	17	3328	c.3071C>T	c.(3070-3072)tCt>tTt	p.S1024F	LAMC1_ENST00000466964.1_3'UTR	NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	1024	Laminin EGF-like 11.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACAATCGGTCTTGGCCTGGC	0.463000													29	70					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98744738	98744738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98744738C>T	ENST00000477737.1	+	6	943	c.739C>T	c.(739-741)Cct>Tct	p.P247S	VWA3B_ENST00000451075.2_Missense_Mutation_p.P97S|VWA3B_ENST00000435344.1_Missense_Mutation_p.P247S	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	247										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGGGGATGTTCCTGAAGAATC	0.498000													47	108					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417464	150417464	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150417464C>T	ENST00000307194.5	+	3	512	c.372C>T	c.(370-372)ttC>ttT	p.F124F		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGTCGGTTCACCGCCCAGG	0.627000													16	39					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3656589	3656589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3656589C>T	ENST00000263087.4	-	14	1761	c.1663G>A	c.(1663-1665)Gag>Aag	p.E555K		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	555					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CCCACCTGCTCGCTGAGACGG	0.572000													6	12					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433410	140433410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140433410G>A	ENST00000306549.3	+	1	2432	c.2355G>A	c.(2353-2355)ggG>ggA	p.G785G		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		785					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGCCACTGGGGAGATAAAAA	0.453000													40	106					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101592853	101592853	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101592853C>T	ENST00000310954.6	-	8	1721	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	479					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GCAAATGGCTCATTTTCACAT	0.328000													23	56					0	0	1	0	0
POMGNT1	55624	broad.mit.edu	37	1	46659974	46659974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46659974G>A	ENST00000371992.1	-	9	1501	c.851C>T	c.(850-852)cCc>cTc	p.P284L	POMGNT1_ENST00000371984.3_Missense_Mutation_p.P284L|POMGNT1_ENST00000535522.1_Missense_Mutation_p.P262L|POMGNT1_ENST00000396420.3_3'UTR|POMGNT1_ENST00000371986.3_Missense_Mutation_p.P284L	NM_001243766.1	NP_001230695.1	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	284					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					GATGGGTGTGGGGTCCTTGCA	0.602000													21	60					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045554	53045554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53045554C>T	ENST00000309680.3	-	1	394	c.373G>A	c.(373-375)Ggt>Agt	p.G125S		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	125	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		cccccaaaacctccaaagcgg	0.617000													9	29					0	0	1	0	0
UCHL1	7345	broad.mit.edu	37	4	41263915	41263915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41263915C>T	ENST00000284440.4	+	6	578	c.434C>T	c.(433-435)gCc>gTc	p.A145V	UCHL1_ENST00000503431.1_Missense_Mutation_p.A145V|UCHL1_ENST00000504818.1_3'UTR|UCHL1_ENST00000508768.1_Intron|UCHL1_ENST00000512788.1_Missense_Mutation_p.A145V	NM_004181.4	NP_004172.2	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	145					cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|skin(2)	8						GCCCATGATGCCGTGGCACAG	0.458000													6	42					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35778739	35778739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:35778739G>A	ENST00000187397.4	+	16	1985	c.1529G>A	c.(1528-1530)cGa>cAa	p.R510Q	ARPP21_ENST00000337271.5_Missense_Mutation_p.R456Q|ARPP21_ENST00000444190.1_Missense_Mutation_p.R456Q|ARPP21_ENST00000417925.1_Missense_Mutation_p.R476Q|ARPP21_ENST00000458225.1_Missense_Mutation_p.R476Q	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	510	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CAGCCCCTGCGAAGCGCCATG	0.612000													68	70					0	0	1	0	0
N4BP2	55728	broad.mit.edu	37	4	40123361	40123361	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40123361T>A	ENST00000261435.6	+	9	4046	c.3630T>A	c.(3628-3630)acT>acA	p.T1210T		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1210						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						GAGCTGTCACTCCTGAAAACC	0.423000													40	73					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64216856	64216856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64216856G>A	ENST00000205948.6	-	5	457	c.420C>T	c.(418-420)atC>atT	p.I140I		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	140	Sushi 3.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			GAGGGCAGATGATGGCTGGGA	0.368000													30	72					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39159080	39159080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39159080C>T	ENST00000359534.3	-	5	1424	c.1086G>A	c.(1084-1086)ctG>ctA	p.L362L		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	362					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						CTTTGCTCCTCAGTGTCTGTG	0.632000													13	38					0	0	1	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89416832	89416832	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89416832G>A	ENST00000490686.1	-	0	378																											AACACTGTGGGAGGGTAACTA	0.522000													31	110					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74153399	74153399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74153399G>A	ENST00000443185.2	-	3	1929	c.1612C>T	c.(1612-1614)Cgc>Tgc	p.R538C	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	538					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CGCGCGCGGCGATGCACGCGT	0.701000													14	19					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24835206	24835206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24835206G>A	ENST00000376454.3	+	21	5815	c.5785G>A	c.(5785-5787)Gga>Aga	p.G1929R	KIAA1217_ENST00000458595.1_Missense_Mutation_p.G1335R|KIAA1217_ENST00000376462.1_Missense_Mutation_p.G1250R|KIAA1217_ENST00000396445.1_3'UTR|KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000376452.3_Missense_Mutation_p.G1360R	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1929					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGCACAGAATGGAAGTTCAAG	0.483000													26	61					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124355019	124355019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124355019C>T	ENST00000409039.3	+	43	7297	c.7272C>T	c.(7270-7272)ttC>ttT	p.F2424F		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2424	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGAGGAAATTCATCAACATCC	0.438000													9	29					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6262879	6262879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6262879G>A	ENST00000379936.2	+	5	1251	c.1136G>A	c.(1135-1137)gGa>gAa	p.G379E	CNGA4_ENST00000533426.1_Missense_Mutation_p.G148E	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	379					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCGCAAAGGAGACATTGGC	0.552000													54	205					0	0	1	0	0
KBTBD13	390594	broad.mit.edu	37	15	65370431	65370431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65370431G>A	ENST00000432196.2	+	1	1278	c.1278G>A	c.(1276-1278)gaG>gaA	p.E426E		NM_001101362.2	NP_001094832.1	C9JR72	KBTBD_HUMAN	kelch repeat and BTB (POZ) domain containing 13	426						cytoplasm				lung(1)|prostate(1)|skin(1)	3						TGCTCAGGGAGAAAGCCGGCT	0.647000													5	16					0	0	1	0	0
PDCD10	11235	broad.mit.edu	37	3	167437899	167437899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167437899G>A	ENST00000392750.2	-	3	464	c.47C>T	c.(46-48)tCc>tTc	p.S16F	PDCD10_ENST00000497056.2_Missense_Mutation_p.S16F|PDCD10_ENST00000461494.1_Missense_Mutation_p.S16F|PDCD10_ENST00000470131.1_Missense_Mutation_p.S16F|PDCD10_ENST00000492396.1_Intron|PDCD10_ENST00000487947.2_Missense_Mutation_p.S16F|PDCD10_ENST00000473645.2_Missense_Mutation_p.S16F|PDCD10_ENST00000471885.1_Missense_Mutation_p.S16F	NM_007217.3	NP_009148.2	Q9BUL8	PDC10_HUMAN	programmed cell death 10	16					angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			central_nervous_system(1)|kidney(1)|lung(8)|urinary_tract(2)	12						AGAAACCATGGATGTGGTCTC	0.398000													30	76					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71144021	71144021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71144021G>A	ENST00000344870.4	-	2	271	c.239C>T	c.(238-240)tCg>tTg	p.S80L	LARP6_ENST00000560052.1_5'UTR|LARP6_ENST00000299213.8_Intron	NM_197958.1	NP_932062.1	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	0					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						tacaatgaacgaagcaagcat	0.443000													33	57					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62265794	62265794	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62265794G>A	ENST00000258991.3	-	5	2263	c.2179C>T	c.(2179-2181)Ccc>Tcc	p.P727S	TEX2_ENST00000584379.1_Intron|TEX2_ENST00000583097.1_Intron			Q8IWB9	TEX2_HUMAN	testis expressed 2	724				PGLLP -> LRAFA (in Ref. 2; CAH10519).	signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AAGAAGACGGGGGCTATTCAC	0.493000													14	54					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19460865	19460865	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19460865G>A	ENST00000396229.2	+	5	1709	c.958_splice	c.e5-1	p.V320_splice	TMC5_ENST00000542583.2_Splice_Site_p.V320_splice|TMC5_ENST00000541464.1_Splice_Site_p.V320_splice|TMC5_ENST00000381414.4_Splice_Site_p.V320_splice	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	320						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TCCCTCCAGTGAACCCTGCTT	0.463000													31	122					0	0	1	0	0
GMPR2	51292	broad.mit.edu	37	14	24702446	24702446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24702446C>T	ENST00000557854.1	+	1	318	c.41C>T	c.(40-42)cCg>cTg	p.P14L	GMPR2_ENST00000559910.1_5'UTR|GMPR2_ENST00000456667.3_5'UTR|GMPR2_ENST00000559836.1_5'UTR|GMPR2_ENST00000559104.1_Missense_Mutation_p.P14L|GMPR2_ENST00000420554.2_Missense_Mutation_p.P14L|GMPR2_ENST00000399440.2_5'UTR|GMPR2_ENST00000348719.7_5'UTR|GMPR2_ENST00000355299.4_5'UTR			Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2	0					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			large_intestine(4)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(265;0.0181)		ATCGCTACCCCGAGGCTAAGC	0.527000													95	231					0	0	1	0	0
DDX42	11325	broad.mit.edu	37	17	61886222	61886222	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61886222C>T	ENST00000578681.1	+	11	1667	c.1066C>T	c.(1066-1068)Cga>Tga	p.R356*	DDX42_ENST00000583590.1_Nonsense_Mutation_p.R356*|DDX42_ENST00000457800.2_Nonsense_Mutation_p.R356*|DDX42_ENST00000359353.5_Nonsense_Mutation_p.R237*|DDX42_ENST00000389924.2_Nonsense_Mutation_p.R356*	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	356	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						ATATAATCTTCGATCAGTGGC	0.443000													29	119					0	0	1	0	0
BLVRB	645	broad.mit.edu	37	19	40953902	40953902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40953902G>A	ENST00000263368.4	-	5	666	c.515C>T	c.(514-516)cCc>cTc	p.P172L	BLVRB_ENST00000595483.1_Missense_Mutation_p.P129L	NM_000713.2	NP_000704.1	P30043	BLVRB_HUMAN	biliverdin reductase B (flavin reductase (NADPH))	172					heme catabolic process	cytosol	biliverdin reductase activity|binding|flavin reductase activity			large_intestine(3)|lung(3)	6			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)		NADH(DB00157)|Riboflavin(DB00140)	GACCCTTGAGGGCCCTCGTCC	0.562000													15	50					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124401103	124401103	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124401103C>T	ENST00000409039.3	+	62	10493	c.10468C>T	c.(10468-10470)Cct>Tct	p.P3490S		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3490	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATACATCGATCCTGTGATTGA	0.433000													14	73					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241172	126241172	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126241172T>G	ENST00000394329.3	+	1	3619	c.3606T>G	c.(3604-3606)gaT>gaG	p.D1202E		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1202	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ACATGAAGGATATAAATGATA	0.418000													22	64					0	0	1	0	0
ZNF696	79943	broad.mit.edu	37	8	144378535	144378535	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144378535C>T	ENST00000330143.3	+	3	1099	c.690C>T	c.(688-690)acC>acT	p.T230T		NM_030895.2	NP_112157.2	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			ACCGCCGCACCCACACCGGGG	0.726000													3	17					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46375487	46375487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46375487G>A	ENST00000302177.2	+	2	421	c.224G>A	c.(223-225)gGg>gAg	p.G75E		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	75					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		GCCCCCCTGGGGCCCACTTTC	0.711000													11	42					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33941323	33941323	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33941323C>T	ENST00000389232.4	+	31	4099	c.4029C>T	c.(4027-4029)gtC>gtT	p.V1343V	RYR3_ENST00000415757.3_Silent_p.V1343V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1343	4 X approximate repeats.|B30.2/SPRY 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CATCCTGTGTCTGGGTCGGAT	0.542000													47	121					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3614674	3614674	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3614674G>A	ENST00000301749.7	-	0	669				NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000324659.8_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GCAGGAGGGAGGCCAGCCTGT	0.706000													4	16					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7340402	7340402	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:7340402C>T	ENST00000486284.1	+	3	1042	c.768C>T	c.(766-768)atC>atT	p.I256I	GRM7_ENST00000357716.4_Silent_p.I256I|GRM7_ENST00000403881.1_Silent_p.I256I|GRM7_ENST00000402647.2_Silent_p.I256I|GRM7_ENST00000389336.4_Silent_p.I256I	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	256					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CCGTGAGAATCCCCCAGGAAC	0.473000													33	63					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135485428	135485428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135485428C>T	ENST00000394143.1	+	22	8892	c.8601C>T	c.(8599-8601)atC>atT	p.I2867I	GPR112_ENST00000370652.1_Silent_p.I2867I|GPR112_ENST00000287534.4_Silent_p.I2620I|GPR112_ENST00000394141.1_Silent_p.I2662I|GPR112_ENST00000412101.1_Silent_p.I2662I	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2867					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGGTGGCAATCACAGTCAGTG	0.502000													12	39					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20825709	20825709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20825709G>A	ENST00000328879.4	-	3	477	c.321C>T	c.(319-321)ttC>ttT	p.F107F	KLHL22_ENST00000440659.2_Intron	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	107	BTB.				cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AGGTGTATATGAAATGTAGGA	0.512000													45	84					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4929324	4929324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4929324C>T	ENST00000359350.4	+	1	725	c.725C>T	c.(724-726)tCc>tTc	p.S242F	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACCTGTGTCTCCCACATCTGT	0.468000													71	166					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537225	5537225	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5537225G>A	ENST00000380184.1	-	1	710	c.447C>T	c.(445-447)gcC>gcT	p.A149A	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	149										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CCACAAAGTGGGCCAGTTCCA	0.527000													9	95					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030033	95030033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95030033G>A	ENST00000557004.1	+	2	635	c.214G>A	c.(214-216)Ggg>Agg	p.G72R	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000298841.5_Missense_Mutation_p.G72R|SERPINA4_ENST00000555095.1_Missense_Mutation_p.G72R			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	72					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		GGAGACCCCGGGGAAGAACAT	0.607000													32	74					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121942288	121942288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121942288C>T	ENST00000442488.2	-	4	1258	c.1191G>A	c.(1189-1191)aaG>aaA	p.K397K	FEZF1_ENST00000331178.4_Silent_p.K393K|FEZF1_ENST00000427185.2_Silent_p.K347K	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	397					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						TGAAAGGCTTCTTGTCGTTGT	0.562000													50	135					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108013935	108013935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108013935G>A	ENST00000280758.5	+	11	3153	c.2625G>A	c.(2623-2625)gcG>gcA	p.A875A	BTBD11_ENST00000357167.4_Silent_p.A412A|BTBD11_ENST00000420571.2_Silent_p.A756A|BTBD11_ENST00000490090.2_Silent_p.A875A	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	875						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TCCTGAAAGCGAGCAAGGTAT	0.507000													9	77					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56343630	56343630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56343630C>T	ENST00000262290.4	+	11	1952	c.1636C>T	c.(1636-1638)Cat>Tat	p.H546Y	LPO_ENST00000582328.1_Missense_Mutation_p.H463Y|LPO_ENST00000543544.1_Missense_Mutation_p.H487Y|LPO_ENST00000421678.2_Missense_Mutation_p.H463Y	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	546					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						TCACAGGATCCATGGCTTTGA	0.532000													4	44					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86468644	86468644	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86468644C>T	ENST00000361669.2	+	4	2913	c.1814C>T	c.(1813-1815)cCc>cTc	p.P605L	GRM3_ENST00000546348.1_Missense_Mutation_p.P197L|GRM3_ENST00000536043.1_Missense_Mutation_p.P477L|GRM3_ENST00000394720.2_Intron|GRM3_ENST00000439827.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	605					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AACAACACACCCTTGGTCAAA	0.483000													23	85					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101593663	101593663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101593663G>A	ENST00000310954.6	-	7	1543	c.1257C>T	c.(1255-1257)ttC>ttT	p.F419F		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	419					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GAGTAGCTGCGAAGCTGGATG	0.294000													9	80					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495309	71495309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71495309G>A	ENST00000296755.7	+	5	6425	c.6127G>A	c.(6127-6129)Gag>Aag	p.E2043K		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2043						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ATACTGTTACGAGACTGCAGA	0.448000													37	131					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20974808	20974808	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20974808G>A	ENST00000261383.3	-	53	10397	c.10398C>T	c.(10396-10398)ttC>ttT	p.F3466F	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3466					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATCCTTGAGAGAACTTCCAAG	0.522000													5	55					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181764142	181764142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181764142C>T	ENST00000526775.1	+	44	6149	c.5984C>T	c.(5983-5985)tCc>tTc	p.S1995F	CACNA1E_ENST00000367567.4_Missense_Mutation_p.S1621F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.S1946F|CACNA1E_ENST00000367570.1_Missense_Mutation_p.S2014F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.S2038F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.S2057F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.S2008F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2057					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TACCACTCCTCCTTGCGGCTG	0.542000													10	41					0	0	1	0	0
DUSP26	78986	broad.mit.edu	37	8	33449694	33449694	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:33449694C>T	ENST00000256261.4	-	4	990	c.473G>A	c.(472-474)cGa>cAa	p.R158Q	DUSP26_ENST00000523956.1_Missense_Mutation_p.R158Q	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	158	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		GGTGGCGGATCGGCTCACGCC	0.577000													9	18					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40061891	40061891	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40061891C>T	ENST00000336649.4	+	26	4002	c.4002C>T	c.(4000-4002)ttC>ttT	p.F1334F	CACNA1I_ENST00000404898.1_Silent_p.F1293F|CACNA1I_ENST00000402142.3_Silent_p.F1328F|CACNA1I_ENST00000401624.1_Silent_p.F1328F|CACNA1I_ENST00000400164.3_Silent_p.F1293F|CACNA1I_ENST00000407673.1_Silent_p.F1293F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1328					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding	p.F1328L(1)|p.F1293L(1)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCCAGCTCTTCAAGGGCAAGT	0.567000													43	104					0	0	1	0	0
QRFP	347148	broad.mit.edu	37	9	133768912	133768912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133768912C>T	ENST00000343079.1	-	1	313	c.314G>A	c.(313-315)gGg>gAg	p.G105E		NM_198180.1	NP_937823.1	P83859	OX26_HUMAN	pyroglutamylated RFamide peptide	105					locomotory behavior|neuropeptide signaling pathway|positive regulation of blood pressure|regulation of feeding behavior	extracellular region	neuropeptide hormone activity|orexigenic neuropeptide QRFP receptor binding			cervix(1)|endometrium(3)|lung(1)|skin(2)	7	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.17e-05)|Epithelial(140;0.000267)		GGTCTTCTCCCCCGCAGCAGG	0.647000													36	106					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447684	226447684	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:226447684C>T	ENST00000272907.6	+	4	1964	c.1551C>T	c.(1549-1551)ctC>ctT	p.L517L	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	517																	TGACCAGCCTCTTCTCCTCCG	0.697000													9	19					0	0	1	0	0
BBOX1	8424	broad.mit.edu	37	11	27077035	27077035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:27077035C>T	ENST00000263182.3	+	3	426	c.58C>T	c.(58-60)Ctc>Ttc	p.L20F	BBOX1_ENST00000525090.1_Missense_Mutation_p.L20F|BBOX1_ENST00000528583.1_Missense_Mutation_p.L20F|BBOX1_ENST00000527505.1_3'UTR|BBOX1_ENST00000529202.1_Missense_Mutation_p.L20F|RP11-1L12.3_ENST00000526061.1_RNA	NM_003986.2	NP_003977.1	O75936	BODG_HUMAN	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	20					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	23					Succinic acid(DB00139)|Vitamin C(DB00126)	GATGCAGATCCTCTGGTATGA	0.498000													26	60					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999223	27999223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27999223C>T	ENST00000441525.1	-	1	343	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	77	Glu-rich.									NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						TCGACGTCTTCACTTGAACTT	0.488000													40	39					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141609344	141609344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141609344G>A	ENST00000389484.3	-	28	5559	c.4588C>T	c.(4588-4590)Cct>Tct	p.P1530S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1530					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCTGCACAAGGATTGGGAGCT	0.453000										TSP Lung(27;0.18)			35	100					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94539793	94539793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94539793G>A	ENST00000289495.5	+	1	584	c.368G>A	c.(367-369)cGa>cAa	p.R123Q	PPP1R9A_ENST00000340694.4_Missense_Mutation_p.R123Q|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.R123Q|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.R123Q|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.R123Q|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.R123Q	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	123	Actin-binding.					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GTTTCTGAACGAATTAGTAGA	0.403000										HNSCC(28;0.073)			39	109					0	0	1	0	0
LIMD1	8994	broad.mit.edu	37	3	45637408	45637408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45637408C>T	ENST00000273317.4	+	1	1058	c.1037C>T	c.(1036-1038)tCc>tTc	p.S346F	LIMD1_ENST00000440097.1_Missense_Mutation_p.S346F|LIMD1_ENST00000465039.1_Intron	NM_014240.2	NP_055055.1	Q9UGP4	LIMD1_HUMAN	LIM domains containing 1	346					cytoplasmic mRNA processing body assembly|gene silencing by miRNA|multicellular organismal development|negative regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasmic mRNA processing body|nucleus|RNA-induced silencing complex	protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.011)|KIRC - Kidney renal clear cell carcinoma(197;0.0264)|Kidney(197;0.0315)		TCTTACCTTTCCAGTTCTGCC	0.612000													16	73					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96294492	96294492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96294492C>T	ENST00000277165.6	+	10	1984	c.1790C>T	c.(1789-1791)cCg>cTg	p.P597L	FAM120A_ENST00000475933.1_3'UTR|FAM120A_ENST00000340893.4_Missense_Mutation_p.P597L|FAM120A_ENST00000333936.5_Missense_Mutation_p.P625L	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	597						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GACCTGCCTCCGGCCGCTCTG	0.418000													47	171					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655984	40655984	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:40655984G>A	ENST00000406785.1	-	2	1626	c.1437C>T	c.(1435-1437)atC>atT	p.I479I	SLC8A1_ENST00000408028.2_Silent_p.I479I|SLC8A1_ENST00000542756.1_Silent_p.I479I|SLC8A1_ENST00000542024.1_Silent_p.I479I|SLC8A1_ENST00000403092.1_Silent_p.I479I|SLC8A1_ENST00000405901.3_Silent_p.I479I|SLC8A1_ENST00000405269.1_Silent_p.I479I|SLC8A1_ENST00000332839.4_Silent_p.I479I|SLC8A1_ENST00000402441.1_Silent_p.I479I|SLC8A1_ENST00000406391.2_Silent_p.I479I			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	479	Calx-beta 1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CATCATCTATGATACCCACTC	0.423000													32	59					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181705452	181705452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181705452G>A	ENST00000526775.1	+	21	3412	c.3247G>A	c.(3247-3249)Gca>Aca	p.A1083T	CACNA1E_ENST00000367567.4_Missense_Mutation_p.A709T|CACNA1E_ENST00000358338.5_Missense_Mutation_p.A1034T|CACNA1E_ENST00000367570.1_Missense_Mutation_p.A1102T|CACNA1E_ENST00000360108.3_Missense_Mutation_p.A1083T|CACNA1E_ENST00000367573.2_Missense_Mutation_p.A1102T|CACNA1E_ENST00000357570.5_Missense_Mutation_p.A1053T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1102					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTGAAGGAGGCAGAGATCAG	0.498000													9	13					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45706614	45706614	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45706614G>A	ENST00000291582.5	+	2	434	c.307_splice	c.e2+1	p.D103_splice		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	103	HSR.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		CTTCCCCAAAGGTGGGTCCTG	0.637000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				23	68					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628755	3628755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3628755C>T	ENST00000325418.4	+	1	1545	c.1526C>T	c.(1525-1527)gCc>gTc	p.A509V	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	509	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										ACACCCGTAGCCATAAAAATC	0.443000													32	33					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003810	57003810	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57003810G>A	ENST00000606794.1	-	1	865	c.669C>T	c.(667-669)ttC>ttT	p.F223F		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	223						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TTTGGGCGATGAAGAAGTAAC	0.627000													20	66					0	0	1	0	0
GAA	2548	broad.mit.edu	37	17	78084546	78084546	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78084546C>T	ENST00000302262.3	+	10	1677	c.1458C>T	c.(1456-1458)gcC>gcT	p.A486A	GAA_ENST00000390015.3_Silent_p.A486A	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	486					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGTCCACTGCCTTCCCCGACT	0.647000													6	78					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97081904	97081904	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:97081904G>A	ENST00000335456.7	-	7	1451	c.1431C>T	c.(1429-1431)acC>acT	p.T477T	NUTM2F_ENST00000341207.4_Silent_p.T477T|NUTM2F_ENST00000253262.4_Silent_p.T492T					NUT family member 2F																		CCTGGGCAAGGGTGAGTCCTT	0.612000													66	111					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57938654	57938654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57938654G>A	ENST00000564448.1	-	26	2660	c.2600C>T	c.(2599-2601)tCt>tTt	p.S867F	CNGB1_ENST00000251102.8_Missense_Mutation_p.S873F			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	873					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GATCATCACAGAGAAAGCAAA	0.572000													17	150					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39978721	39978721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39978721C>T	ENST00000373257.3	+	7	877	c.786C>T	c.(784-786)tcC>tcT	p.S262S		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	262					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				GGCCCGAGTCCTCAGTGGTCC	0.627000													3	11					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31608171	31608171	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31608171T>G	ENST00000170150.3	+	12	1313	c.1118T>G	c.(1117-1119)gTg>gGg	p.V373G		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	373						extracellular region	lipid binding										GTGTCCAAGGTGAAGCTTCAG	0.612000													17	61					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11177099	11177099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11177099G>A	ENST00000361445.4	-	50	7054	c.6978C>T	c.(6976-6978)gtC>gtT	p.V2326V	MTOR_ENST00000376838.1_Silent_p.V531V	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2326	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CCATTGACATGACCGCTAAAG	0.378000													49	116					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533134	169533134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169533134C>T	ENST00000449804.2	+	1	218	c.173C>T	c.(172-174)aCc>aTc	p.T58I	FOXI1_ENST00000306268.6_Missense_Mutation_p.T58I	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	58	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TATGGGGCCACCCCCAACCCC	0.682000									Pendred syndrome				9	19					0	0	1	0	0
CD81	975	broad.mit.edu	37	11	2415403	2415403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2415403C>T	ENST00000263645.5	+	3	516	c.260C>T	c.(259-261)tCc>tTc	p.S87F	CD81_ENST00000524805.1_3'UTR|CD81_ENST00000492627.1_Missense_Mutation_p.S16F|CD81_ENST00000526072.1_Missense_Mutation_p.S16F|CD81_ENST00000481687.1_Missense_Mutation_p.S93F|CD81_ENST00000381036.3_Missense_Mutation_p.S125F	NM_004356.3	NP_004347.1	P60033	CD81_HUMAN	CD81 molecule	87					activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding			endometrium(1)|lung(3)|skin(1)	5		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		ATCCAGGAATCCCAGTGCCTG	0.677000													7	40					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4909091	4909091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4909091C>T	ENST00000396658.4	+	4	1201	c.498C>T	c.(496-498)acC>acT	p.T166T	UBN1_ENST00000545171.1_Silent_p.T166T|UBN1_ENST00000262376.6_Silent_p.T166T|UBN1_ENST00000590769.1_Silent_p.T166T	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	166	Sufficient for interaction with HIRA.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						ACTCGGGAACCCTGCAGTTTA	0.388000													13	105					0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	56000536	56000536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56000536C>T	ENST00000313264.4	-	1	201	c.126G>A	c.(124-126)atG>atA	p.M42I		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TGACATTCTTCATGTTGAAAT	0.358000													28	61					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178417660	178417660	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178417660G>A	ENST00000231188.5	-	4	1123	c.945C>T	c.(943-945)ccC>ccT	p.P315P	GRM6_ENST00000517717.1_Silent_p.P315P	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	315					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GGCTCAAGATGGGTGAGGTCT	0.667000													3	15					0	0	1	0	0
GZMH	2999	broad.mit.edu	37	14	25076911	25076911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:25076911C>T	ENST00000216338.4	-	3	290	c.246G>A	c.(244-246)caG>caA	p.Q82Q	GZMH_ENST00000557220.2_Intron|GZMH_ENST00000382548.4_Silent_p.Q82Q|RP11-104E19.1_ENST00000555300.1_RNA|RP11-104E19.1_ENST00000557736.1_RNA	NM_033423.3	NP_219491.1	P20718	GRAH_HUMAN	granzyme H (cathepsin G-like 2, protein h-CCPX)	82	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)	12				GBM - Glioblastoma multiforme(265;0.0267)		GGGTCCGCTCCTGTTCCTTGA	0.542000													56	151					0	0	1	0	0
C6orf223	221416	broad.mit.edu	37	6	43968437	43968437	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43968437G>A	ENST00000336600.5	+	1	101	c.81_splice	c.e1+1	p.R27_splice	RP5-1120P11.1_ENST00000422059.1_RNA|RP5-1120P11.1_ENST00000607590.1_RNA|C6orf223_ENST00000448947.2_3'UTR|C6orf223_ENST00000439969.2_Splice_Site_p.R27_splice	NM_001171992.1|NM_153246.4	NP_001165463.1|NP_694978.2	Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	27										central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			TTCTGCGGAGGGTGAGACTGA	0.632000													3	8					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29278138	29278138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29278138G>A	ENST00000266943.6	-	5	1612	c.1243C>T	c.(1243-1245)Cct>Tct	p.P415S	SLC46A3_ENST00000475385.1_5'UTR|SLC46A3_ENST00000380814.4_Missense_Mutation_p.P415S	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	415					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		GTGAAGCCAGGGTACCAAGCA	0.408000													17	51					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50159027	50159027	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50159027G>A	ENST00000371564.3	-	1	231	c.12C>T	c.(10-12)ccC>ccT	p.P4P	NFATC2_ENST00000414705.1_Intron|NFATC2_ENST00000396009.3_Silent_p.P4P	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	4					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GCTGCCGCTCGGGGGCGTTCA	0.751000													3	11					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106320527	106320527	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106320527G>A	ENST00000390559.2	-	0	1282																											CTTGTCCACGGTCCTCTCGGT	0.627000													27	70					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68748123	68748123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68748123C>T	ENST00000309106.3	-	1	332	c.333G>A	c.(331-333)gtG>gtA	p.V111V		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	111						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGCTCAGGCCCACTGTGTAGG	0.592000													7	53					0	0	1	0	0
RGS5	8490	broad.mit.edu	37	1	163122409	163122409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:163122409G>A	ENST00000313961.5	-	4	592	c.315C>T	c.(313-315)tcC>tcT	p.S105S	RGS5_ENST00000527988.1_5'UTR|RGS5_ENST00000530507.1_Silent_p.S105S|RGS5_ENST00000367903.3_Silent_p.S125S	NM_001254749.1|NM_003617.3	NP_001241678.1|NP_003608.1	O15539	RGS5_HUMAN	regulator of G-protein signaling 5	105	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity	p.S105S(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20			LUSC - Lung squamous cell carcinoma(543;0.187)			TCTTGGCAGGGGACTTGATCT	0.448000													72	272					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183710474	183710474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183710474G>A	ENST00000511685.1	+	25	5656	c.5533G>A	c.(5533-5535)Gga>Aga	p.G1845R	TENM3_ENST00000406950.2_Missense_Mutation_p.G1845R					teneurin transmembrane protein 3																		AGATTATGACGGACAGGGGAG	0.478000													10	22					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28273189	28273189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28273189C>T	ENST00000305242.5	-	5	698	c.606G>A	c.(604-606)aaG>aaA	p.K202K	ARMC4_ENST00000239715.3_Silent_p.K59K	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	202							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CTATATCCTTCTTCACCGTCA	0.338000													54	119					0	0	1	0	0
DEDD2	162989	broad.mit.edu	37	19	42713887	42713887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42713887G>A	ENST00000595337.1	-	4	641	c.554C>T	c.(553-555)cCc>cTc	p.P185L	DEDD2_ENST00000598727.1_Missense_Mutation_p.P185L|DEDD2_ENST00000336034.4_Missense_Mutation_p.P180L|DEDD2_ENST00000596251.1_Missense_Mutation_p.P185L|DEDD2_ENST00000593804.1_5'UTR	NM_001270614.1	NP_001257543.1	Q8WXF8	DEDD2_HUMAN	death effector domain containing 2	185					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(2)	5		Prostate(69;0.0704)				AGGTCTGGCGGGCTCTGACTG	0.672000													41	109					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632771	122632771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122632771C>T	ENST00000195173.4	-	15	2369	c.2066G>A	c.(2065-2067)cGa>cAa	p.R689Q	SEMA5B_ENST00000357599.3_Missense_Mutation_p.R689Q|SEMA5B_ENST00000451055.2_Missense_Mutation_p.R743Q			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	689	TSP type-1 1.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GCTGCAACTTCGCTGGCGGAC	0.682000													30	60					0	0	1	0	0
TSNAXIP1	55815	broad.mit.edu	37	16	67854817	67854817	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67854817C>T	ENST00000388833.3	+	3	438	c.61C>T	c.(61-63)Cga>Tga	p.R21*	TSNAXIP1_ENST00000562321.1_Intron|TSNAXIP1_ENST00000415766.3_Intron|TSNAXIP1_ENST00000561639.1_Nonsense_Mutation_p.R75*	NM_018430.2	NP_060900.2	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein 1	21					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|soft_tissue(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		TTTGCAAAATCGAAAACCCTG	0.582000													74	229					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37002154	37002154	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37002154G>A	ENST00000379242.3	+	9	1048	c.746G>A	c.(745-747)aGg>aAg	p.R249K	VIT_ENST00000379241.3_Intron|VIT_ENST00000404084.1_Intron|VIT_ENST00000389975.3_Missense_Mutation_p.R249K|VIT_ENST00000497382.1_5'UTR|VIT_ENST00000401530.1_Missense_Mutation_p.R249K	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	249						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				GGTATCCAAAGGCAAGATCCT	0.507000													25	33					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836195	142836195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142836195C>T	ENST00000291009.3	+	3	269	c.229C>T	c.(229-231)Cct>Tct	p.P77S		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	77						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		TAGCAGCATCCCTCTACAAGG	0.428000													30	90					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20782881	20782881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20782881C>T	ENST00000359062.3	+	6	1620	c.1580C>T	c.(1579-1581)tCc>tTc	p.S527F	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	527					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TCGCCCTGCTCCTCACCTCTC	0.453000													39	104					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159831822	159831822	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:159831822G>A	ENST00000297151.4	-	14	1845	c.1458C>T	c.(1456-1458)ctC>ctT	p.L486L		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	486					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTACCTCCATGAGGGTTTGAG	0.363000													4	45					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400019	89400019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89400019G>A	ENST00000439576.2	+	12	4577	c.4203G>A	c.(4201-4203)gaG>gaA	p.E1401E	ACAN_ENST00000559004.1_Silent_p.E1401E|ACAN_ENST00000561243.1_Silent_p.E1401E|ACAN_ENST00000352105.7_Silent_p.E1401E	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1401					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AAGTTCTAGAGACTACTGCCC	0.542000													104	165					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3236042	3236042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3236042C>T	ENST00000217939.6	-	6	5834	c.5680G>A	c.(5680-5682)Gct>Act	p.A1894T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1894	Ig-like C2-type 3.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTCATAAGAGCTCCTGGAGAA	0.408000													14	14					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167085308	167085308	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167085308G>A	ENST00000375387.4	-	22	4442	c.4102C>T	c.(4102-4104)Cgt>Tgt	p.R1368C	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.R1356C|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1367C|SCN9A_ENST00000303354.6_Missense_Mutation_p.R1368C			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1367						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CATTCGGAACGATTTGGAACT	0.403000													54	205					0	0	1	0	0
CCDC113	29070	broad.mit.edu	37	16	58312481	58312481	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58312481C>T	ENST00000219299.4	+	8	1066	c.987C>T	c.(985-987)atC>atT	p.I329I	CCDC113_ENST00000443128.2_Silent_p.I275I	NM_014157.3	NP_054876.2	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113	329						protein complex				large_intestine(4)|lung(6)|ovary(1)|urinary_tract(1)	12						GGGAGAAGATCTTAAATGCGG	0.572000													19	45					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284387	52284387	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52284387G>A	ENST00000301190.6	+	5	884	c.657G>A	c.(655-657)gtG>gtA	p.V219V	ANKRD33_ENST00000538991.1_Silent_p.V25V|ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Silent_p.V94V	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	94										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		TGACAGCAGTGGACCCTGTTC	0.617000													8	16					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189012603	189012603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189012603G>A	ENST00000512729.1	-	7	1462	c.1088C>T	c.(1087-1089)cCa>cTa	p.P363L	TRIML2_ENST00000326754.3_Missense_Mutation_p.P388L	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	363	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GTCTCCATTTGGGATACAGAG	0.453000													17	104					0	0	1	0	0
BSND	7809	broad.mit.edu	37	1	55474208	55474208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55474208G>A	ENST00000371265.4	+	4	1124	c.870G>A	c.(868-870)aaG>aaA	p.K290K		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	290						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						AACCTGAGAAGGAAGAGGAAG	0.582000													21	73					0	0	1	0	0
DENND6A	201627	broad.mit.edu	37	3	57620487	57620487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:57620487G>A	ENST00000311128.5	-	13	1212	c.1142C>T	c.(1141-1143)cCt>cTt	p.P381L	RP11-755B10.2_ENST00000470427.1_RNA	NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		AACCTGCTTAGGAATTTCACC	0.254000													7	21					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55929392	55929392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55929392C>T	ENST00000244728.5	-	24	2553	c.2156G>A	c.(2155-2157)gGa>gAa	p.G719E	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.G119E|COL21A1_ENST00000535941.1_Missense_Mutation_p.G719E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G716E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	719	Collagen-like 4.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CCCTGGAATTCCCTGTCTTCC	0.323000													4	11					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455864	5455864	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5455864G>T	ENST00000222033.4	+	1	439	c.362G>T	c.(361-363)gGc>gTc	p.G121V		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	121						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GCGCTGTTCGGCGTCCCCCTG	0.682000													18	110					2.89027e-11	2.90251e-11	1	1	0
ACSL5	51703	broad.mit.edu	37	10	114181785	114181785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:114181785G>A	ENST00000393081.1	+	16	1775	c.1468G>A	c.(1468-1470)Gaa>Aaa	p.E490K	ACSL5_ENST00000369410.3_Missense_Mutation_p.E272K|ACSL5_ENST00000354273.4_Missense_Mutation_p.E490K|ACSL5_ENST00000433418.1_Missense_Mutation_p.E490K|ACSL5_ENST00000356116.1_Missense_Mutation_p.E546K|ACSL5_ENST00000354655.4_Missense_Mutation_p.E490K	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	490					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		AGTGAATAATGAAGGAGAGGT	0.473000													28	59					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39535000	39535000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39535000G>A	ENST00000265707.5	+	15	1621	c.1576G>A	c.(1576-1578)Gaa>Aaa	p.E526K	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.E502K	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	526	Cys-rich.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TTCTCTGCATGAAAGATCTGA	0.308000													16	56					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	31144214	31144214	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:31144214C>T	ENST00000543491.1	+	3	3511	c.3511C>T	c.(3511-3513)Cag>Tag	p.Q1171*				O60245	PCDH7_HUMAN	protocadherin 7	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						GAAGAAGAGCCAGCCTAAACT	0.562000													48	119					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74644535	74644535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:74644535G>A	ENST00000541184.1	-	7	1138	c.661C>T	c.(661-663)Ctc>Ttc	p.L221F	ZDHHC15_ENST00000373361.3_3'UTR|ZDHHC15_ENST00000373367.3_Missense_Mutation_p.L230F	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	230						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						TAACCAAAGAGAATCACAAGG	0.378000													15	13					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167247009	167247009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167247009G>A	ENST00000308378.3	-	10	1486	c.1181C>T	c.(1180-1182)tCa>tTa	p.S394L	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Missense_Mutation_p.S458L|WDR49_ENST00000476376.1_Missense_Mutation_p.S219L	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	394										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TCCTCCACATGATACCAGGTT	0.383000													27	48					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663181	34663181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34663181G>A	ENST00000488417.1	+	2	796	c.676G>A	c.(676-678)Ggc>Agc	p.G226S	C1orf94_ENST00000373374.3_Missense_Mutation_p.G36S	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	36							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AGAGGACAGGGGCCGCATCCT	0.542000													21	57					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711165	41711165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41711165C>T	ENST00000400454.1	-	7	1865	c.1388G>A	c.(1387-1389)gGg>gAg	p.G463E		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	463	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GACCACGTTCCCCTCCGACGT	0.612000													27	54					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2193006	2193006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2193006G>A	ENST00000381178.1	-	1	29	c.11C>T	c.(10-12)cCc>cTc	p.P4L	TH_ENST00000352909.3_Missense_Mutation_p.P4L|TH_ENST00000333684.5_Missense_Mutation_p.P4L|TH_ENST00000381175.1_Missense_Mutation_p.P4L	NM_199292.2	NP_954986.2	P07101	TY3H_HUMAN	tyrosine hydroxylase	4					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(7)|skin(1)	11		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	GGTGGCGTCGGGGGTGGGCAT	0.662000													16	35					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60902947	60902947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60902947G>A	ENST00000252999.3	-	36	4838	c.4772C>T	c.(4771-4773)cCc>cTc	p.P1591L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1591	Laminin EGF-like 15.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCTGTGAGGGGGTCACACAC	0.662000													27	45					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133899584	133899584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133899584C>T	ENST00000220616.4	+	9	2007	c.1967C>T	c.(1966-1968)cCa>cTa	p.P656L	TG_ENST00000377869.1_Missense_Mutation_p.P656L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	656	Thyroglobulin type-1 5.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGTGGACAGCCAAGGTGCCCC	0.547000													17	47					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28586965	28586965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28586965G>A	ENST00000434452.1	-	12	1950	c.1796C>T	c.(1795-1797)cCt>cTt	p.P599L	DSC3_ENST00000360428.4_Missense_Mutation_p.P599L	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	599	Cadherin 5.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			AGGTTCATCAGGATCAACAGC	0.368000													28	45					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43610138	43610138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43610138C>T	ENST00000360835.3	-	16	2137	c.2011G>A	c.(2011-2013)Ggg>Agg	p.G671R		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	671					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				AGACCAAGCCCGTCGCTGCTG	0.647000													14	30					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	140781	140781	+	Missense_Mutation	SNP	G	G	A	rs143686104	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140781G>A	ENST00000283426.6	+	1	409	c.359G>A	c.(358-360)gGg>gAg	p.G120E		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	120					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CAAGCTGTGGGGACCCCAAAC	0.662000													11	27					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72301234	72301234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72301234G>A	ENST00000263563.6	+	17	2333	c.2065G>A	c.(2065-2067)Ggt>Agt	p.G689S		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CCCCGAGGTGGGTGAGGAGGA	0.632000													8	24					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127686617	127686617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127686617C>T	ENST00000508053.1	-	27	3729	c.2755G>A	c.(2755-2757)Gaa>Aaa	p.E919K	FBN2_ENST00000262464.4_Missense_Mutation_p.E919K|FBN2_ENST00000508989.1_Missense_Mutation_p.E886K			P35556	FBN2_HUMAN	fibrillin 2	919	TB 4.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCACAGCATTCAGATTTCAGA	0.552000													28	80					0	0	1	0	0
UBR3	130507	broad.mit.edu	37	2	170863617	170863617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170863617C>T	ENST00000272793.5	+	28	4197	c.4147C>T	c.(4147-4149)Cct>Tct	p.P1383S	UBR3_ENST00000418381.1_Missense_Mutation_p.P1383S|UBR3_ENST00000392631.1_Missense_Mutation_p.P204S			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1383					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						GGAAAATAACCCTTGGCAACG	0.483000													11	40					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26673526	26673526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26673526C>T	ENST00000288710.2	+	13	1740	c.1666C>T	c.(1666-1668)Cac>Tac	p.H556Y		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		ATATCGAGCTCACCGTTTATC	0.383000													27	111					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42693479	42693479	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42693479G>A	ENST00000372999.1	+	7	1010	c.816G>A	c.(814-816)cgG>cgA	p.R272R	TOX2_ENST00000435864.2_Silent_p.R192R|TOX2_ENST00000423191.1_Silent_p.R272R|TOX2_ENST00000358131.5_Intron|TOX2_ENST00000341197.3_Silent_p.R314R	NM_032883.2	NP_116272.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CAGCCTACCGGGCTAGCCTCG	0.562000													31	105					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34029359	34029359	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:34029359G>A	ENST00000346562.2	+	4	479	c.405G>A	c.(403-405)caG>caA	p.Q135Q	NPAS3_ENST00000551492.1_Silent_p.Q172Q|NPAS3_ENST00000357798.5_Silent_p.Q154Q|NPAS3_ENST00000551008.1_Silent_p.Q65Q|NPAS3_ENST00000341321.4_Silent_p.Q167Q|NPAS3_ENST00000548645.1_Silent_p.Q137Q|NPAS3_ENST00000547068.1_Silent_p.Q63Q|NPAS3_ENST00000356141.4_Silent_p.Q167Q	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CACTAAATCAGGAAGGAAAAT	0.338000													23	56					0	0	1	0	0
NRL	4901	broad.mit.edu	37	14	24552052	24552052	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24552052G>A	ENST00000561028.1	-	2	325	c.6C>T	c.(4-6)gcC>gcT	p.A2A	NRL_ENST00000396997.1_Silent_p.A2A|NRL_ENST00000397002.2_Silent_p.A2A			P54845	NRL_HUMAN	neural retina leucine zipper	2					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding			lung(2)	2				GBM - Glioblastoma multiforme(265;0.0181)		TGGGGGGCAGGGCCATTCTGG	0.602000													10	46					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7621800	7621800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7621800G>A	ENST00000256861.6	-	9	1414	c.1336C>T	c.(1336-1338)Ctg>Ttg	p.L446L	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Silent_p.L446L|ITIH5_ENST00000298441.6_Silent_p.L232L|ITIH5_ENST00000446830.2_Silent_p.L228L|ITIH5_ENST00000397145.2_Silent_p.L446L	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	446	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.L446L(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TTCTCCAGCAGCCTGAAGTCC	0.617000													21	58					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110492333	110492333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110492333G>A	ENST00000378402.5	+	55	9396	c.9292G>A	c.(9292-9294)Gaa>Aaa	p.E3098K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3098	G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCTTACAGAGAAGTTGTTTT	0.353000										HNSCC(38;0.096)			4	8					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150647458	150647458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150647458C>T	ENST00000392968.2	-	7	3028	c.1908G>A	c.(1906-1908)ctG>ctA	p.L636L	KCNH2_ENST00000330883.4_Silent_p.L392L|KCNH2_ENST00000430723.3_Silent_p.L732L|KCNH2_ENST00000262186.5_Silent_p.L732L			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	732					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GTGAGCGGTTCAGGTGCAGGC	0.657000													28	55					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400660	85400660	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85400660C>T	ENST00000258888.5	+	6	3464	c.3297C>T	c.(3295-3297)ttC>ttT	p.F1099F		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1099					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGCCACCTTCCTGCCCTCTG	0.622000													22	76					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7011416	7011416	+	Silent	SNP	C	C	T	rs148253534		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:7011416C>T	ENST00000389658.3	-	25	3663	c.3570G>A	c.(3568-3570)acG>acA	p.T1190T		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1190	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCCCTCGGTCGTGCCCCTCA	0.597000													4	8					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408205	29408205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29408205G>A	ENST00000444197.2	+	1	1123	c.413G>A	c.(412-414)cGg>cAg	p.R138Q	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	138			R -> W (in dbSNP:rs17177646).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CTGAGCCACCGGGTGTGTCTA	0.637000													23	51					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873661	36873661	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36873661C>T	ENST00000301807.6	-	21	7528	c.5631G>A	c.(5629-5631)tgG>tgA	p.W1877*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.W2427*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.W1877*	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2427					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TGACATTCTTCCAGAGGCGGG	0.522000													36	100					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12704715	12704715	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12704715C>T	ENST00000376221.1	+	1	150	c.150C>T	c.(148-150)ttC>ttT	p.F50F		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	50						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		ATTGCATATTCCTCTACCTGG	0.507000													58	174					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990484	63990484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:63990484C>T	ENST00000370658.5	-	5	584	c.551G>A	c.(550-552)aGa>aAa	p.R184K	LGSN_ENST00000370657.4_Silent_p.K324K	NM_001143940.1|NM_016571.2	NP_001137412.1|NP_057655.2	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	348					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	ACATGTTTTTCTTCCTATCGA	0.453000													12	76					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449242	104449242	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104449242G>A	ENST00000361820.3	-	2	1540	c.940C>T	c.(940-942)Cag>Tag	p.Q314*		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	314					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTCTCAAGCTGGATCTGTAGG	0.488000													26	50					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116930318	116930318	+	Silent	SNP	C	C	T	rs148339655		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116930318C>T	ENST00000356083.3	+	3	874	c.483C>T	c.(481-483)ctC>ctT	p.L161L		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	161	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						ACCTGGCCCTCGAGCTCCGAG	0.701000													14	37					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104099448	104099448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104099448C>T	ENST00000388887.2	+	37	4143	c.3939C>T	c.(3937-3939)ttC>ttT	p.F1313F		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1313					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CCTCCTATTTCATGGGAAGAC	0.403000													14	46					0	0	1	0	0
FAM71D	161142	broad.mit.edu	37	14	67664956	67664956	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:67664956G>A	ENST00000556046.1	+	3	302	c.78G>A	c.(76-78)ccG>ccA	p.P26P				Q8N9W8	FA71D_HUMAN	family with sequence similarity 71, member D	26										breast(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(1)	13		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		CCCATGATCCGAGAGATCTTC	0.428000													55	116					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188426	7188426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7188426C>T	ENST00000542285.1	-	11	1521	c.1372G>A	c.(1372-1374)Gaa>Aaa	p.E458K				P00736	C1R_HUMAN	complement component 1, r subcomponent	510					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTTTGCGCTTCGTGTTCCTTG	0.612000													12	56					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114279872	114279872	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114279872C>T	ENST00000357077.4	+	38	10151	c.10098C>T	c.(10096-10098)acC>acT	p.T3366T	ANK2_ENST00000264366.6_Silent_p.T3333T|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3333					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCTAGACACCTCTGTCCAGA	0.458000													13	128					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90020813	90020813	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90020813G>A	ENST00000268122.4	-	7	1115	c.1047C>T	c.(1045-1047)atC>atT	p.I349I	RHCG_ENST00000544600.1_Silent_p.I349I	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	349					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					TGCCGCCTATGATGCCAGGAA	0.582000													6	73					0	0	1	0	0
AKNAD1	254268	broad.mit.edu	37	1	109377600	109377600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109377600C>T	ENST00000370001.3	-	8	1883	c.1615G>A	c.(1615-1617)Ggg>Agg	p.G539R	AKNAD1_ENST00000369995.3_Missense_Mutation_p.G539R|AKNAD1_ENST00000369994.1_Intron|AKNAD1_ENST00000357393.4_Missense_Mutation_p.G246R	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	539										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						TCCTGCGGCCCTCCTTGGGGT	0.657000													27	68					0	0	1	0	0
MCU	90550	broad.mit.edu	37	10	74619011	74619011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74619011C>T	ENST00000536019.1	+	3	595	c.150C>T	c.(148-150)ttC>ttT	p.F50F	MCU_ENST00000357157.6_Silent_p.F99F|MCU_ENST00000373053.3_Silent_p.F99F	NM_001270680.1	NP_001257609.1	Q8NE86	MCU_HUMAN	mitochondrial calcium uniporter	99					elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	14						GCTGTCAGTTCACACTCAAGC	0.438000													64	153					0	0	1	0	0
CLEC1A	51267	broad.mit.edu	37	12	10241809	10241809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10241809G>A	ENST00000315330.4	-	2	190	c.128C>T	c.(127-129)cCc>cTc	p.P43L	CLEC1A_ENST00000457018.2_Intron|CLEC1A_ENST00000420265.2_Intron	NM_016511.2	NP_057595.2	Q8NC01	CLC1A_HUMAN	C-type lectin domain family 1, member A	43					cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	23						CGTTGAAGAGGGAGCCCTGTG	0.527000													8	40					0	0	1	0	0
SRP68	6730	broad.mit.edu	37	17	74044000	74044000	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74044000G>A	ENST00000307877.2	-	10	1290	c.1129C>T	c.(1129-1131)Caa>Taa	p.Q377*	SRP68_ENST00000539137.1_Nonsense_Mutation_p.Q339*|SRP68_ENST00000602720.1_Nonsense_Mutation_p.Q38*|SRP68_ENST00000542536.2_5'UTR|SRP68_ENST00000355113.5_Nonsense_Mutation_p.Q276*	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	377					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						TGCAAGTATTGAAGATTAGAC	0.284000													35	111					0	0	1	0	0
LUZP2	338645	broad.mit.edu	37	11	25004683	25004683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:25004683G>A	ENST00000533227.1	+	9	638	c.351G>A	c.(349-351)atG>atA	p.M117I	LUZP2_ENST00000336930.6_Missense_Mutation_p.M203I	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	203						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						AGTCACAGATGAAAGCAATGA	0.408000													60	138					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176659540	176659540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176659540C>T	ENST00000367662.3	+	5	3569	c.2405C>T	c.(2404-2406)cCg>cTg	p.P802L	PAPPA2_ENST00000367661.3_Missense_Mutation_p.P802L	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	802					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CCAGGGGCTCCGTTCACCAAC	0.567000													12	103					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069754	9069754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9069754G>A	ENST00000397910.4	-	3	17895	c.17692C>T	c.(17692-17694)Cca>Tca	p.P5898S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5900	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGAGTGTGGAAATCTCTGA	0.517000													26	92					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189852856	189852856	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189852856C>T	ENST00000304636.3	+	6	748	c.578C>T	c.(577-579)tCc>tTc	p.S193F	COL3A1_ENST00000317840.5_Missense_Mutation_p.S193F	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	193	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CATCCTGGTTCCCCTGTAAGT	0.398000													39	96					0	0	1	0	0
OR6C3	254786	broad.mit.edu	37	12	55726102	55726102	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55726102C>T	ENST00000379667.1	+	1	618	c.618C>T	c.(616-618)ttC>ttT	p.F206F		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						CTTTGCTGTTCACTTTGGCAT	0.368000													43	156					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125856770	125856770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125856770G>A	ENST00000393434.2	-	10	1459	c.1110C>T	c.(1108-1110)ggC>ggT	p.G370G	ALDH1L1_ENST00000273450.3_Silent_p.G380G|ALDH1L1_ENST00000393431.2_Silent_p.G370G|ALDH1L1_ENST00000472186.1_Silent_p.G370G|ALDH1L1_ENST00000452905.2_Silent_p.G269G	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	370	Acyl carrier.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CTAACTCCAGGCCATCACACA	0.567000													20	60					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801196	140801196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140801196C>T	ENST00000398587.2	+	1	435	c.402C>T	c.(400-402)ttC>ttT	p.F134F	PCDHGA9_ENST00000573521.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Silent_p.F134F|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCCAGCTTCCAGGAGGACG	0.473000													7	19					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42127274	42127274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42127274C>T	ENST00000382448.4	+	3	334	c.325C>T	c.(325-327)Ctg>Ttg	p.L109L	JMJD7-PLA2G4B_ENST00000476036.1_3'UTR|JMJD7_ENST00000397299.4_Silent_p.L109L|JMJD7-PLA2G4B_ENST00000542534.1_Silent_p.L109L|JMJD7-PLA2G4B_ENST00000342159.4_Silent_p.L109L|JMJD7_ENST00000408047.1_Silent_p.L10L	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		0					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						CCGCCTGCCCCTGAGCTTCGT	0.652000													47	98					0	0	1	0	0
PANX2	56666	broad.mit.edu	37	22	50615914	50615914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50615914C>T	ENST00000395842.2	+	2	773	c.773C>T	c.(772-774)aCc>aTc	p.T258I	PANX2_ENST00000159647.5_Missense_Mutation_p.T258I	NM_052839.3	NP_443071.2	Q96RD6	PANX2_HUMAN	pannexin 2	258					protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)	7		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		AACGAGTTCACCTGCGCGCTG	0.692000													4	9					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72300277	72300277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72300277C>T	ENST00000334456.5	-	12	1126	c.881G>A	c.(880-882)gGa>gAa	p.G294E	PDE2A_ENST00000544570.1_Missense_Mutation_p.G287E|PDE2A_ENST00000418754.2_Missense_Mutation_p.G179E|PDE2A_ENST00000444035.2_Missense_Mutation_p.G285E|PDE2A_ENST00000540345.1_Missense_Mutation_p.G285E|PDE2A_ENST00000376450.3_Intron	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	294	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GCCCAGGCATCCTGTCAACTA	0.577000													6	17					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135015029	135015029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:135015029G>A	ENST00000304613.3	+	17	3035	c.3014G>A	c.(3013-3015)aGg>aAg	p.R1005K	KNDC1_ENST00000368571.2_Missense_Mutation_p.R940K|KNDC1_ENST00000368572.2_Missense_Mutation_p.R1007K			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1005					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GCCATGGCCAGGACCAGCAGC	0.627000													49	110					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20682893	20682893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20682893G>A	ENST00000404938.2	+	6	1053	c.401G>A	c.(400-402)cGa>cAa	p.R134Q		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	318	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						ACTGCAGCACGACAGACCAAG	0.418000													15	27					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159900508	159900508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159900508C>T	ENST00000368094.1	-	14	1984	c.1787G>A	c.(1786-1788)aGc>aAc	p.S596N	IGSF9_ENST00000361509.3_Missense_Mutation_p.S580N|IGSF9_ENST00000493195.1_5'UTR	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	596	Fibronectin type-III 1.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GACGATTTCGCTGAAGGGACC	0.602000													4	59					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57924639	57924639	+	Missense_Mutation	SNP	C	C	T	rs138018355	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57924639C>T	ENST00000574161.1	+	7	805	c.686C>T	c.(685-687)tCg>tTg	p.S229L	GCOM1_ENST00000396180.1_Missense_Mutation_p.S198L|GCOM1_ENST00000380560.2_Missense_Mutation_p.S160L|GCOM1_ENST00000380561.2_Missense_Mutation_p.S198L|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Missense_Mutation_p.S229L|GCOM1_ENST00000572390.1_Missense_Mutation_p.S229L|MYZAP_ENST00000267853.5_Missense_Mutation_p.S229L|GCOM1_ENST00000587652.1_Missense_Mutation_p.S229L|MYZAP_ENST00000380565.4_Missense_Mutation_p.S229L|GCOM1_ENST00000380568.3_Missense_Mutation_p.S229L	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		229					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						TAGGTGGAATCGTCCCAAGAA	0.517000													43	113					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16138400	16138400	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16138400C>T	ENST00000399408.2	+	8	1078	c.903C>T	c.(901-903)atC>atT	p.I301I	ABCC1_ENST00000351154.5_Silent_p.I301I|ABCC1_ENST00000346370.5_Silent_p.I301I|ABCC1_ENST00000349029.5_Silent_p.I301I|ABCC1_ENST00000345148.5_Silent_p.I301I|ABCC1_ENST00000399410.3_Silent_p.I301I			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	301					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AGGCTTTGATCGTCAAGTCCC	0.532000													24	62					0	0	1	0	0
SNX20	124460	broad.mit.edu	37	16	50707846	50707846	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50707846G>A	ENST00000330943.4	-	4	593	c.422C>T	c.(421-423)cCc>cTc	p.P141L	SNX20_ENST00000423026.2_Intron|SNX20_ENST00000300590.3_Intron	NM_182854.2	NP_878274.1	Q7Z614	SNX20_HUMAN	sorting nexin 20	141	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(2)|stomach(1)	15						GTGCTTCCTGGGAAACTCCAC	0.602000													7	58					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961518	73961518	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73961518G>A	ENST00000373468.1	-	3	3525	c.2874C>T	c.(2872-2874)ctC>ctT	p.L958L	KIAA2022_ENST00000055682.5_Silent_p.L958L			Q5QGS0	K2022_HUMAN	KIAA2022	958					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						CATCAGATGGGAGTTGGGTAT	0.423000													13	105					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603770	5603770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5603770G>A	ENST00000423158.3	+	2	641	c.429G>A	c.(427-429)gcG>gcA	p.A143A	NTF3_ENST00000331010.6_Silent_p.A130A|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	130					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						CCGTGGTGGCGAACAGAACAT	0.602000													20	82					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600189	92600189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92600189G>A	ENST00000298047.6	+	21	11958	c.11941G>A	c.(11941-11943)Ggc>Agc	p.G3981S	FAT3_ENST00000533797.1_Missense_Mutation_p.G316S|FAT3_ENST00000409404.2_Missense_Mutation_p.G3981S|FAT3_ENST00000525166.1_Missense_Mutation_p.G3831S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3981	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGTGCTCAGCGGCTTCCAGGG	0.617000										TCGA Ovarian(4;0.039)			4	6					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141370273	141370273	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:141370273A>C	ENST00000389328.4	-	9	1679	c.1665T>G	c.(1663-1665)gcT>gcG	p.A555A	TRAPPC9_ENST00000438773.2_Silent_p.A457A|TRAPPC9_ENST00000389327.3_Silent_p.A448A	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	457					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						TCTGGACCGCAGCCCAGCCTC	0.512000													22	36					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43668391	43668391	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43668391C>T	ENST00000564079.1	+	2	414	c.174C>T	c.(172-174)ttC>ttT	p.F58F	TUBGCP4_ENST00000260383.7_Silent_p.F58F|TUBGCP4_ENST00000570081.1_3'UTR	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	58					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton	p.F58L(1)		breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		TCACTGAGTTCATTGAACAGT	0.542000											OREG0023088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	89					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39549961	39549961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:39549961G>A	ENST00000567887.1	+	1	228	c.71G>A	c.(70-72)cGa>cAa	p.R24Q	MACF1_ENST00000484793.1_Missense_Mutation_p.R24Q|MACF1_ENST00000361689.2_Missense_Mutation_p.R24Q|MACF1_ENST00000602421.1_Missense_Mutation_p.R24Q|MACF1_ENST00000539005.1_Missense_Mutation_p.R24Q|MACF1_ENST00000372915.3_Missense_Mutation_p.R24Q|MACF1_ENST00000317713.7_Missense_Mutation_p.R24Q|MACF1_ENST00000545844.1_Missense_Mutation_p.R24Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	24	Actin-binding.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CGGAGTGAGCGATCTTACAGG	0.627000													24	59					0	0	1	0	0
WNT10A	80326	broad.mit.edu	37	2	219754737	219754737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219754737C>T	ENST00000258411.3	+	3	1041	c.408C>T	c.(406-408)atC>atT	p.I136I	WNT10A_ENST00000483911.1_3'UTR	NM_025216.2	NP_079492.2	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family, member 10A	136					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|cervix(1)|endometrium(2)|lung(6)|skin(2)	12		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTACGCCATCGCAGCAGCTG	0.617000													12	88					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169539941	169539941	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169539941C>T	ENST00000340806.6	+	1	232	c.232C>T	c.(232-234)Ctg>Ttg	p.L78L		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	78										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						GGTCCTCTACCTGGATAAGAA	0.512000													43	93					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929783	121929783	+	Missense_Mutation	SNP	C	C	T	rs145920249		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:121929783C>T	ENST00000265922.3	-	8	2326	c.1865G>A	c.(1864-1866)cGg>cAg	p.R622Q	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		622					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						TAGCCGAGTCCGACTACGTAG	0.532000													62	103					0	0	1	0	0
DIRC2	84925	broad.mit.edu	37	3	122598136	122598136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122598136C>T	ENST00000261038.5	+	9	1746	c.1348C>T	c.(1348-1350)Ccc>Tcc	p.P450S		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	450					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		CTGGTGCCTTCCCGGGTCGTG	0.458000													136	268					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29938169	29938169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:29938169G>A	ENST00000378993.1	+	8	1688	c.1015G>A	c.(1015-1017)Gga>Aga	p.G339R	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.G339R	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	339	Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TGTTGAAAATGGAAATGGACG	0.433000													42	25					0	0	1	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45971094	45971094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45971094G>A	ENST00000391621.1	-	1	294	c.248C>T	c.(247-249)tCt>tTt	p.S83F	KRTAP10-2_ENST00000498210.1_Intron|TSPEAR_ENST00000323084.4_Intron|TSPEAR_ENST00000397916.1_Intron	NM_198693.2	NP_941966.1	P60368	KR102_HUMAN	keratin associated protein 10-2	83	22 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|lung(4)|skin(1)	6						CTGGCAGCTAGACTGCTGGCA	0.692000													15	149					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7802241	7802241	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:7802241G>A	ENST00000420658.1	-	10	1466	c.1194C>T	c.(1192-1194)atC>atT	p.I398I	AFAP1_ENST00000382543.3_Silent_p.I398I|AFAP1_ENST00000358461.2_Silent_p.I398I|AFAP1_ENST00000360265.4_Silent_p.I398I	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	398	PH 2.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						CCAAACCCGGGATCACCTCGC	0.542000													21	33					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432383	104432383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104432383C>T	ENST00000361820.3	-	3	2911	c.2311G>A	c.(2311-2313)Gag>Aag	p.E771K		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	771					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TAGATCTTCTCACCTACCATG	0.383000													39	71					0	0	1	0	0
CHFR	55743	broad.mit.edu	37	12	133428221	133428221	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:133428221C>G	ENST00000266880.7	-	13	1571	c.1508G>C	c.(1507-1509)cGt>cCt	p.R503P	CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000315585.7_Missense_Mutation_p.R463P|CHFR_ENST00000432561.2_Missense_Mutation_p.R504P|CHFR_ENST00000443047.2_Missense_Mutation_p.R412P|CHFR_ENST00000537522.1_Missense_Mutation_p.R126P|CHFR_ENST00000450056.2_Missense_Mutation_p.R492P			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	504					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		AGGGGCGACACGCGGGTCCTG	0.657000													58	93					0	0	1	0	0
ZRSR1	7310	broad.mit.edu	37	5	112227676	112227676	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:112227676G>A	ENST00000391338.1	+	1	364	c.340G>A	c.(340-342)Gaa>Aaa	p.E114K	REEP5_ENST00000474542.2_Intron|SRP19_ENST00000512790.1_3'UTR|REEP5_ENST00000513339.1_Intron|REEP5_ENST00000379638.4_Intron|REEP5_ENST00000504247.1_Intron|REEP5_ENST00000545426.1_Intron	NM_001204199.1	NP_001191128.1			zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1											breast(1)|skin(1)|stomach(2)	4						aaagttaaaggaacaatggaa	0.428000													9	32					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15535087	15535087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15535087G>A	ENST00000389282.4	-	9	4916	c.4703C>T	c.(4702-4704)cCa>cTa	p.P1568L	WIZ_ENST00000599910.1_Missense_Mutation_p.P885L|WIZ_ENST00000599686.2_Missense_Mutation_p.P752L|WIZ_ENST00000263381.6_Missense_Mutation_p.P711L|WIZ_ENST00000545156.1_Missense_Mutation_p.P882L			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1568						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						GACTCGGGGTGGGGGTTGCCG	0.647000													10	30					0	0	1	0	0
MTSS1	9788	broad.mit.edu	37	8	125565696	125565696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125565696C>T	ENST00000518547.1	-	14	2278	c.1805G>A	c.(1804-1806)gGa>gAa	p.G602E	MTSS1_ENST00000395508.2_Missense_Mutation_p.G376E|MTSS1_ENST00000524090.1_Missense_Mutation_p.G492E|NDUFB9_ENST00000522532.1_Intron|MTSS1_ENST00000325064.5_Missense_Mutation_p.G606E|MTSS1_ENST00000431961.2_Missense_Mutation_p.G320E|MTSS1_ENST00000354184.4_Missense_Mutation_p.G320E|MTSS1_ENST00000378017.3_Missense_Mutation_p.G577E|MTSS1_ENST00000523587.1_5'UTR	NM_014751.4	NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	602					actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TCCAATGGTTCCCCGGCGGAC	0.627000													18	35					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31779004	31779004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31779004C>T	ENST00000375654.4	-	2	935	c.746G>A	c.(745-747)aGg>aAg	p.R249K	HSPA1L_ENST00000417199.3_Missense_Mutation_p.R249K	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	249					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TTTGTGTTTCCTCTTGAACTC	0.592000													39	97					0	0	1	0	0
CHST5	23563	broad.mit.edu	37	16	75563854	75563854	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:75563854G>A	ENST00000336257.3	-	3	1823	c.429C>T	c.(427-429)ttC>ttT	p.F143F	RP11-77K12.7_ENST00000460606.1_3'UTR|CHST5_ENST00000541075.1_Silent_p.F149F	NM_024533.4	NP_078809.2	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	143					N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)	24						TTGCCCAGTTGAAAAAGGCGG	0.607000													33	72					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40594355	40594355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40594355C>T	ENST00000260402.3	-	6	737	c.488G>A	c.(487-489)gGg>gAg	p.G163E	PLCB2_ENST00000456256.2_Missense_Mutation_p.G163E|PLCB2_ENST00000557821.1_Missense_Mutation_p.G163E|PLCB2_ENST00000543785.2_Missense_Mutation_p.G163E	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	163					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CGGAATCTTCCCTTCAGAGTT	0.612000													16	216					0	0	1	0	0
OR51F1	256892	broad.mit.edu	37	11	4790832	4790832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4790832G>A	ENST00000380383.1	-	1	336	c.337C>T	c.(337-339)Ctt>Ttt	p.L113F	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Missense_Mutation_p.L106F			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	106						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		AATCCATGAAGAAAAAACATC	0.443000													11	41					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227886796	227886796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227886796C>T	ENST00000396625.3	-	44	4391	c.4184G>A	c.(4183-4185)gGg>gAg	p.G1395E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1392E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1395	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCCAGGGAGCCCCATGGCTCC	0.522000													56	172					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19758335	19758335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19758335G>A	ENST00000357324.6	-	21	2822	c.2796C>T	c.(2794-2796)gaC>gaT	p.D932D	ATP13A1_ENST00000291503.5_Silent_p.D814D	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	932					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGCTCAGGCGGTCCTGCAGGG	0.637000													10	20					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106153205	106153205	+	Missense_Mutation	SNP	G	G	A	rs61732088	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106153205G>A	ENST00000369704.3	+	11	1780	c.1646G>A	c.(1645-1647)cGa>cAa	p.R549Q		NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	549								p.R549Q(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GAACAGCAGCGAATAGAAAAG	0.453000													14	33					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25448201	25448201	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25448201G>A	ENST00000424208.1	+	0	2047				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CAGCGCTGGAGGAGGACTTGT	0.647000													4	27					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179639748	179639748	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179639748G>A	ENST00000589042.1	-	29	6914	c.6690C>T	c.(6688-6690)ttC>ttT	p.F2230F	TTN_ENST00000342992.6_Silent_p.F2230F|TTN_ENST00000360870.5_Silent_p.F2230F|TTN_ENST00000460472.2_Silent_p.F2184F|TTN_ENST00000342175.6_Silent_p.F2184F|TTN_ENST00000359218.5_Silent_p.F2184F|TTN_ENST00000591111.1_Silent_p.F2230F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1966	Ig-like 11.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTATGGAGAGGAAGTGAACCT	0.388000													23	74					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72691309	72691309	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72691309C>T	ENST00000326165.6	-	7	910	c.799G>A	c.(799-801)Ggc>Agc	p.G267S	CD300LF_ENST00000469092.1_3'UTR|RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000361254.4_3'UTR|CD300LF_ENST00000464910.1_Missense_Mutation_p.G270S|RAB37_ENST00000340415.3_Intron|CD300LF_ENST00000301573.9_3'UTR|CD300LF_ENST00000343125.4_3'UTR|CD300LF_ENST00000583937.1_Missense_Mutation_p.G282S	NM_139018.3	NP_620587.2	Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	267						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						CTGAGGTGGCCCATGTTGCAG	0.607000													23	51					0	0	1	0	0
SP1	6667	broad.mit.edu	37	12	53775537	53775537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53775537C>T	ENST00000426431.2	+	2	141	c.81C>T	c.(79-81)gcC>gcT	p.A27A	SP1_ENST00000327443.4_Silent_p.A34A	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	34	Repressor domain.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GTGGTGGTGCCTTTTCACAGG	0.478000											OREG0021870	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	76					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154562857	154562857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154562857G>A	ENST00000368474.4	-	7	2498	c.2299C>T	c.(2299-2301)Cgc>Tgc	p.R767C	ADAR_ENST00000292205.5_Missense_Mutation_p.R810C|ADAR_ENST00000368471.3_Missense_Mutation_p.R472C	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	767	DRBM 3.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GGGAACCAGCGACCCCCAACT	0.522000													27	74					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243354563	243354563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:243354563G>A	ENST00000366542.1	-	8	916	c.865C>T	c.(865-867)Cca>Tca	p.P289S	CEP170_ENST00000366543.1_Missense_Mutation_p.P289S|CEP170_ENST00000366544.1_Missense_Mutation_p.P289S	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	289						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			ACCTTCCCTGGGGTACTGTCA	0.438000													4	20					0	0	1	0	0
STAM	8027	broad.mit.edu	37	10	17730032	17730032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:17730032C>T	ENST00000377524.3	+	5	519	c.304C>T	c.(304-306)Cct>Tct	p.P102S	STAM_ENST00000540523.1_5'UTR	NM_003473.3	NP_003464.1	Q92783	STAM1_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	102	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	26						ACAGGGTCATCCTAAAGTATG	0.294000													34	96					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655520	46655520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46655520C>T	ENST00000253255.5	-	1	3699	c.3700G>A	c.(3700-3702)Gtg>Atg	p.V1234M		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1234	PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AAAATAGTCACCAAGTAGCAT	0.443000													52	104					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640355	99640355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:99640355C>T	ENST00000547776.2	-	13	2043	c.2044G>A	c.(2044-2046)Gaa>Aaa	p.E682K	ANKS1B_ENST00000547010.1_Missense_Mutation_p.E262K|ANKS1B_ENST00000329257.7_Missense_Mutation_p.E682K|ANKS1B_ENST00000550833.1_5'UTR	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	682						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GTATGGTTTTCGAGTTGGTTG	0.428000													4	28					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44951664	44951664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44951664G>A	ENST00000296125.4	+	11	1478	c.1410G>A	c.(1408-1410)gaG>gaA	p.E470E		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	470					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CTGTAAAAGAGAACTTTCTTC	0.478000													34	68					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	89998001	89998001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:89998001G>A	ENST00000428670.3	-	16	3021	c.2565C>T	c.(2563-2565)ttC>ttT	p.F855F	ATP2B1_ENST00000261173.2_Silent_p.F855F|ATP2B1_ENST00000359142.3_Silent_p.F855F|ATP2B1_ENST00000393164.2_Silent_p.F598F|ATP2B1_ENST00000348959.3_Silent_p.F855F			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	855					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						GGAACTGAAGGAATTTTGAGA	0.383000													22	52					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42344686	42344686	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42344686C>T	ENST00000217026.4	+	14	2189	c.2062C>T	c.(2062-2064)Ctg>Ttg	p.L688L	MYBL2_ENST00000396863.4_Silent_p.L664L	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	688						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCTGGGCCGCCTGAAGCCCAG	0.627000													13	273					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63517538	63517538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63517538C>T	ENST00000377819.5	+	4	2760	c.2606C>T	c.(2605-2607)tCc>tTc	p.S869F	RTN3_ENST00000354497.4_Missense_Mutation_p.S73F|RTN3_ENST00000537981.1_Missense_Mutation_p.S73F|RTN3_ENST00000356000.3_Missense_Mutation_p.S92F|RTN3_ENST00000540798.1_Missense_Mutation_p.S757F|RTN3_ENST00000339997.4_Missense_Mutation_p.S850F|RTN3_ENST00000341307.2_Missense_Mutation_p.S73F	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	869	Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						ATGCTGCTTTCCCTGGCAGCT	0.468000													12	42					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151166599	151166599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151166599C>T	ENST00000282466.3	-	4	1169	c.1170G>A	c.(1168-1170)agG>agA	p.R390R		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	390					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAAGTGGCTCCTTTCTAGTA	0.413000													28	34					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39798741	39798741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39798741G>A	ENST00000248668.4	-	2	1847	c.1848C>T	c.(1846-1848)gcC>gcT	p.A616A		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	616						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CGACGGCGGGGGCAGCCTGGG	0.751000													4	15					0	0	1	0	0
RHBDL3	162494	broad.mit.edu	37	17	30648243	30648243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:30648243C>T	ENST00000269051.4	+	9	1224	c.1210C>T	c.(1210-1212)Ccc>Tcc	p.P404S	RHBDL3_ENST00000538145.1_Missense_Mutation_p.P396S|RHBDL3_ENST00000536287.1_Missense_Mutation_p.P306S	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	404					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				GCCGCCTCCCCCCTGAGGGCT	0.602000													20	18					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135202	156135202	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156135202G>A	ENST00000329476.3	+	2	600	c.111G>A	c.(109-111)gaG>gaA	p.E37E	NPY2R_ENST00000506608.1_Silent_p.E37E	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	37					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CTGACCCTGAGCCAGAGCTTA	0.483000													20	67					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108202275	108202275	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108202275C>T	ENST00000278616.4	+	51	8005	c.7620C>T	c.(7618-7620)gtC>gtT	p.V2540V	C11orf65_ENST00000525729.1_Intron|ATM_ENST00000452508.2_Silent_p.V2540V	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2540	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTCATGAAGTCCTCAATAATG	0.313000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			19	65					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533860	92533860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92533860G>A	ENST00000298047.6	+	9	7698	c.7681G>A	c.(7681-7683)Gaa>Aaa	p.E2561K	FAT3_ENST00000409404.2_Missense_Mutation_p.E2561K|FAT3_ENST00000525166.1_Missense_Mutation_p.E2411K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2561	Cadherin 23.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTAGACCGGGAAAACCCTCT	0.468000										TCGA Ovarian(4;0.039)			11	26					0	0	1	0	0
CASQ2	845	broad.mit.edu	37	1	116311050	116311050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:116311050G>A	ENST00000261448.5	-	1	352	c.113C>T	c.(112-114)tCc>tTc	p.S38F	CASQ2_ENST00000456138.2_Missense_Mutation_p.S38F	NM_001232.3	NP_001223.2	O14958	CASQ2_HUMAN	calsequestrin 2 (cardiac muscle)	38					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	18	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GTTCTTCTCGGAAAGACTTAC	0.438000													92	61					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764208	92764208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92764208C>T	ENST00000318238.4	-	5	2293	c.1077G>A	c.(1075-1077)cgG>cgA	p.R359R	SAMD9L_ENST00000411955.1_Silent_p.R359R|SAMD9L_ENST00000437805.1_Silent_p.R359R	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	359										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AATCTACATCCCGTTGCTTGG	0.368000													33	211					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545533	186545533	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186545533C>T	ENST00000431808.1	-	14	1601	c.1038G>A	c.(1036-1038)cgG>cgA	p.R346R	SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000418609.1_Silent_p.R250R|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000355634.5_Silent_p.R446R|SORBS2_ENST00000284776.7_Silent_p.R346R|SORBS2_ENST00000319471.9_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	346						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TTGGTGAGTCCCGAGGGACAT	0.502000													25	69					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7847480	7847480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7847480G>A	ENST00000328375.1	-	1	39	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AACCCCAAAAGAGTAAACTCT	0.343000													6	59					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51696896	51696896	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51696896C>T	ENST00000267012.4	-	3	253	c.192G>A	c.(190-192)ctG>ctA	p.L64L	BIN2_ENST00000544402.1_Silent_p.L38L|BIN2_ENST00000452142.2_Silent_p.L64L|BIN2_ENST00000604560.1_Silent_p.L37L	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	64	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						GGAAGTTCTTCAGGTCCTTGT	0.438000													22	104					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56953494	56953494	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56953494G>A	ENST00000504904.3	-	7	1589	c.870C>T	c.(868-870)ttC>ttT	p.F290F	ZNF667_ENST00000342634.3_Silent_p.F418F|ZNF667_ENST00000292069.6_Silent_p.F290F|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		ATTTCTTTTTGAAGCCTCTCC	0.358000													13	135					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3318208	3318208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3318208C>T	ENST00000336727.3	+	2	1215	c.311C>T	c.(310-312)tCc>tTc	p.S104F	RGS12_ENST00000344733.5_Missense_Mutation_p.S104F|RGS12_ENST00000543385.1_Missense_Mutation_p.S104F|RGS12_ENST00000382788.3_Missense_Mutation_p.S104F	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	104						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CGCTTCGAATCCTGTTCCAGT	0.473000													25	84					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48677180	48677180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48677180C>T	ENST00000352832.5	+	16	3953	c.3581C>T	c.(3580-3582)cCc>cTc	p.P1194L	CACNA1G_ENST00000512389.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000507336.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000507609.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000354983.4_Missense_Mutation_p.P1194L|CACNA1G_ENST00000503485.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000507896.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000358244.5_Missense_Mutation_p.P1194L|CACNA1G_ENST00000510115.1_Missense_Mutation_p.P1194L|CACNA1G_ENST00000510366.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000502264.1_Missense_Mutation_p.P1194L|CACNA1G_ENST00000429973.2_Missense_Mutation_p.P1217L|CACNA1G_ENST00000416767.4_Missense_Mutation_p.P1217L|CACNA1G_ENST00000360761.4_Missense_Mutation_p.P1194L|CACNA1G_ENST00000515765.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000515411.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000442258.2_Missense_Mutation_p.P1194L|CACNA1G_ENST00000515165.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000505165.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000359106.5_Missense_Mutation_p.P1217L|CACNA1G_ENST00000514717.1_Missense_Mutation_p.P1194L|CACNA1G_ENST00000514181.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000514079.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000513964.1_Missense_Mutation_p.P1217L|CACNA1G_ENST00000507510.2_Missense_Mutation_p.P1217L|CACNA1G_ENST00000513689.2_Missense_Mutation_p.P1217L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1217					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGATGACCCCCCACTGGAT	0.667000													5	33					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51330299	51330299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51330299C>T	ENST00000326856.4	-	4	442	c.313G>A	c.(313-315)Gac>Aac	p.D105N	KLK15_ENST00000416184.1_Missense_Mutation_p.D106N|KLK15_ENST00000596931.1_Missense_Mutation_p.D105N|KLK15_ENST00000598239.1_Missense_Mutation_p.D106N|KLK15_ENST00000301421.2_Missense_Mutation_p.D106N	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	106	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.D106N(1)		breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		AACATGATGTCGTTGCGGTGG	0.687000													20	61					0	0	1	0	0
ARID3C	138715	broad.mit.edu	37	9	34627700	34627700	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34627700G>A	ENST00000378909.2	-	1	404	c.312C>T	c.(310-312)ttC>ttT	p.F104F		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CTACCTGCTTGAATTGTTCCT	0.622000													9	64					0	0	1	0	0
ZNF546	339327	broad.mit.edu	37	19	40520580	40520580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40520580C>T	ENST00000347077.4	+	7	1619	c.1403C>T	c.(1402-1404)cCc>cTc	p.P468L	ZNF546_ENST00000600094.1_Missense_Mutation_p.P442L|ZNF546_ENST00000596894.1_Intron	NM_178544.3	NP_848639.2	Q86UE3	ZN546_HUMAN	zinc finger protein 546	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(15)|lung(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	34	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GGTGAGAAACCCTATGAATGT	0.408000													27	85					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145567885	145567885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:145567885G>A	ENST00000296575.3	+	1	713	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K	HHIP-AS1_ENST00000512359.1_RNA|HHIP_ENST00000434550.2_Missense_Mutation_p.E20K	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	20						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GGGCTTCTTTGAAGGAGATGC	0.597000													21	84					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138208520	138208520	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:138208520T>C	ENST00000409968.1	+	15	3243	c.3065T>C	c.(3064-3066)aTt>aCt	p.I1022T	THSD7B_ENST00000272643.3_Missense_Mutation_p.I1022T|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.I991T					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGAGTGAGAATTCGATCCAAA	0.403000													8	16					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9333638	9333638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9333638G>A	ENST00000261336.2	-	15	1808	c.1780C>T	c.(1780-1782)Cgt>Tgt	p.R594C	PZP_ENST00000381997.2_Missense_Mutation_p.R463C	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TCCACAGCACGAAGGGCACAG	0.587000													12	35					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66358116	66358116	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66358116C>G	ENST00000333861.3	-	1	2438	c.2371G>C	c.(2371-2373)Gag>Cag	p.E791Q		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	791										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						AAGATTAACTCTATCTCCTCC	0.517000													64	162					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51143224	51143224	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:51143224C>T	ENST00000414786.2	+	15	2015	c.1788C>T	c.(1786-1788)ctC>ctT	p.L596L	SHANK3_ENST00000262795.3_Silent_p.L626L|SHANK3_ENST00000445220.2_Silent_p.L611L			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	626										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		TGCAGTATCTCGAGTCGGTGG	0.667000													5	22					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488505	1488505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1488505C>T	ENST00000345913.4	+	9	1567	c.1476C>T	c.(1474-1476)ttC>ttT	p.F492F	TPO_ENST00000382198.1_Silent_p.F319F|TPO_ENST00000349624.3_Silent_p.F319F|TPO_ENST00000329066.4_Silent_p.F492F|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000382201.3_Silent_p.F492F|TPO_ENST00000337415.3_Silent_p.F492F|TPO_ENST00000346956.3_Silent_p.F492F	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	492					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCTTCCGCTTCGGCCATGCCA	0.652000													12	51					0	0	1	0	0
CCR5	1234	broad.mit.edu	37	3	46414494	46414494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46414494C>T	ENST00000343801.4	+	3	458	c.101C>T	c.(100-102)cCt>cTt	p.P34L	CCR5_ENST00000292303.4_Missense_Mutation_p.P34L|CCR5_ENST00000445772.1_Missense_Mutation_p.P34L|RP11-24F11.2_ENST00000451485.1_RNA	NM_000579.3	NP_000570.1	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5 (gene/pseudogene)	34			P -> L (in TZCCR5-179).		cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			central_nervous_system(1)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	CGCCTCCTGCCTCCGCTCTAC	0.453000													48	144					0	0	1	0	0
CLRN2	645104	broad.mit.edu	37	4	17528621	17528621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:17528621G>A	ENST00000511148.2	+	3	717	c.615G>A	c.(613-615)gtG>gtA	p.V205V		NM_001079827.2	NP_001073296.1	A0PK11	CLRN2_HUMAN	clarin 2	205						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|upper_aerodigestive_tract(1)	15						ACTTGGTCGTGGTGGCGATCA	0.507000													30	80					0	0	1	0	0
ZNF512	84450	broad.mit.edu	37	2	27844028	27844028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27844028C>T	ENST00000355467.4	+	14	1487	c.1404C>T	c.(1402-1404)ttC>ttT	p.F468F	ZNF512_ENST00000556601.1_Silent_p.F337F|ZNF512_ENST00000379717.1_Silent_p.F467F|ZNF512_ENST00000416005.2_Silent_p.F439F|RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000413371.2_Silent_p.F391F			Q96ME7	ZN512_HUMAN	zinc finger protein 512	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F468F(2)		breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					AGGACTGGTTCGTTGTAAACC	0.418000													22	74					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52827674	52827674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52827674C>T	ENST00000252245.5	-	1	635	c.415G>A	c.(415-417)Gac>Aac	p.D139N		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	139	Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		ATGGTGGGGTCGATTTGCAGG	0.592000													49	102					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62675554	62675554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62675554G>A	ENST00000498273.1	+	4	1403	c.1108G>A	c.(1108-1110)Gag>Aag	p.E370K		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	370	Glu-rich.									breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						TAAGCCAGAGGAGATGAAAAA	0.438000													31	137					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883252	228883252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228883252G>A	ENST00000392056.3	-	7	2364	c.2318C>T	c.(2317-2319)cCa>cTa	p.P773L	SPHKAP_ENST00000344657.5_Missense_Mutation_p.P773L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	773						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ATTGCTAAGTGGAGAGCTGCT	0.502000													53	130					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129833610	129833610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:129833610G>A	ENST00000421865.2	+	63	9009	c.8960G>A	c.(8959-8961)gGa>gAa	p.G2987E		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2987	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AAAATGGATGGAATGGGTATT	0.388000													58	106					0	0	1	0	0
SUSD5	26032	broad.mit.edu	37	3	33249379	33249379	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33249379G>A	ENST00000309558.3	-	3	747	c.330C>T	c.(328-330)atC>atT	p.I110I		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	110	Link.				cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CAGCTCTCATGATTTGCTGTT	0.418000													30	71					0	0	1	0	0
ART3	419	broad.mit.edu	37	4	77003470	77003470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77003470C>T	ENST00000355810.4	+	3	682	c.563C>T	c.(562-564)tCa>tTa	p.S188L	ART3_ENST00000341029.5_Missense_Mutation_p.S188L|ART3_ENST00000513494.1_3'UTR|ART3_ENST00000349321.3_Missense_Mutation_p.S188L	NM_001130016.2	NP_001123488.1	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3	188					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|stomach(1)	16			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTGGCATATTCAGCCAAACCT	0.423000													15	25					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64535070	64535070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64535070G>A	ENST00000377390.3	-	10	1652	c.1315C>T	c.(1315-1317)Cct>Tct	p.P439S	SF1_ENST00000334944.5_Missense_Mutation_p.P439S|SF1_ENST00000433274.2_Missense_Mutation_p.P413S|SF1_ENST00000377387.1_Missense_Mutation_p.P564S|SF1_ENST00000422298.2_Missense_Mutation_p.P324S|SF1_ENST00000227503.9_Missense_Mutation_p.P439S|SF1_ENST00000377394.3_Missense_Mutation_p.P439S	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	439	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						TGGTGCCCAGGAGGGTGGGGG	0.607000											OREG0021062	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	100					0	0	1	0	0
BHLHE22	27319	broad.mit.edu	37	8	65494180	65494180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:65494180G>A	ENST00000321870.1	+	1	1367	c.833G>A	c.(832-834)cGa>cAa	p.R278Q	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	278	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						CCCTCGGTGCGAAAGCTCTCC	0.647000													8	17					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360043	27360043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27360043G>A	ENST00000335524.3	-	3	1680	c.1155C>T	c.(1153-1155)gtC>gtT	p.V385V		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	385										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGGTAGTGACCTGTTTTG	0.582000													32	83					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64821816	64821816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64821816C>T	ENST00000358658.3	-	6	925	c.898G>A	c.(898-900)Gga>Aga	p.G300R	NAALADL1_ENST00000339885.2_Missense_Mutation_p.G300R|NAALADL1_ENST00000356632.3_Intron|NAALADL1_ENST00000340252.4_Missense_Mutation_p.G300R|NAALADL1_ENST00000355721.3_Missense_Mutation_p.G259R|NAALADL1_ENST00000355369.2_Missense_Mutation_p.G300R	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	300	NAALADase.				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						GCCAAAGTTCCGTTGAGGTTA	0.637000													15	40					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29848378	29848378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29848378G>A	ENST00000399218.4	-	6	2139	c.2084C>T	c.(2083-2085)cCc>cTc	p.P695L	GAREM_ENST00000269209.6_Missense_Mutation_p.P696L	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		GGCTGACTTGGGACAACCAGA	0.547000													42	80					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62687998	62687998	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:62687998C>T	ENST00000281156.4	-	4	734	c.456G>A	c.(454-456)ttG>ttA	p.L152L		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TAATCTCTTCCAATGCATGAC	0.373000													29	97					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117968808	117968808	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117968808C>T	ENST00000425217.1	-	12	1707	c.1653G>A	c.(1651-1653)ccG>ccA	p.P551P	KSR2_ENST00000302438.5_Silent_p.P277P|KSR2_ENST00000339824.5_Silent_p.P580P|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	580					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCTCCGGCACCGGCACCACAT	0.552000													48	119					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52568891	52568891	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52568891G>A	ENST00000389534.4	-	7	2703	c.2244C>T	c.(2242-2244)tcC>tcT	p.S748S	ZNF841_ENST00000594295.1_Silent_p.S748S|ZNF841_ENST00000359973.2_Intron|ZNF841_ENST00000426391.2_Silent_p.S632S|ZNF432_ENST00000598446.1_Intron	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	632				L -> P (in Ref. 1; BAC04190).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						GGGTTGTAGTGGAGTTAAAGA	0.428000													12	17					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47350726	47350726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47350726G>A	ENST00000400314.1	+	13	1161	c.823G>A	c.(823-825)Gaa>Aaa	p.E275K	PCBP3_ENST00000400308.1_Missense_Mutation_p.E249K|PCBP3_ENST00000468429.1_3'UTR|PCBP3_ENST00000449640.1_Missense_Mutation_p.E275K|PCBP3_ENST00000400310.1_Intron|PRED62_ENST00000593412.1_Intron|PCBP3_ENST00000400304.1_Missense_Mutation_p.E265K|PCBP3_ENST00000400309.1_Missense_Mutation_p.E274K			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	275					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		acactcctccgaagaagctca	0.522000													14	42					0	0	1	0	0
CASD1	64921	broad.mit.edu	37	7	94185045	94185045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94185045C>T	ENST00000297273.4	+	18	2656	c.2369C>T	c.(2368-2370)tCc>tTc	p.S790F		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	790						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			ATCTTATCATCCATTCAAGAT	0.338000													34	81					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76395539	76395539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76395539C>T	ENST00000357063.3	+	15	3850	c.2590C>T	c.(2590-2592)Cct>Tct	p.P864S	LMO7_ENST00000341547.4_Missense_Mutation_p.P530S|LMO7_ENST00000377534.3_Missense_Mutation_p.P864S|LMO7_ENST00000321797.8_Missense_Mutation_p.P579S|LMO7_ENST00000465261.2_Missense_Mutation_p.P579S|LMO7_ENST00000526202.1_Missense_Mutation_p.P429S			Q8WWI1	LMO7_HUMAN	LIM domain 7	864						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AATTCAGCTTCCTTCTCAAAG	0.443000													8	128					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164584	139164584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139164584C>T	ENST00000395297.1	-	13	2304	c.2134G>A	c.(2134-2136)Gaa>Aaa	p.E712K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	712										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGCAAGACTTCCCGATCACTG	0.552000										HNSCC(54;0.14)			9	27					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47300925	47300925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:47300925G>A	ENST00000319190.5	+	20	2808	c.2440G>A	c.(2440-2442)Gag>Aag	p.E814K	CALM2_ENST00000422269.1_Intron|TTC7A_ENST00000263737.6_Missense_Mutation_p.E460K|TTC7A_ENST00000409245.1_Missense_Mutation_p.E780K|TTC7A_ENST00000394850.2_Missense_Mutation_p.E838K	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	814							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TACGTGCCACGAGGCGTGGCA	0.662000													30	50					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110835662	110835662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110835662C>T	ENST00000296632.3	-	6	674	c.540G>A	c.(538-540)atG>atA	p.M180I	STARD4_ENST00000512160.1_3'UTR	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	180	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		ACTGAGGAATCATCCCACGCA	0.413000													50	97					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226564933	226564933	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226564933G>A	ENST00000366794.5	-	13	1960	c.1817C>T	c.(1816-1818)tCc>tTc	p.S606F		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	606					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		ATCCTCCTTGGACGGCATCTG	0.473000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					112	313					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43625192	43625192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43625192G>A	ENST00000405006.4	-	29	4496	c.4145C>T	c.(4144-4146)aCc>aTc	p.T1382I	THADA_ENST00000405975.2_Missense_Mutation_p.T1382I|THADA_ENST00000330266.7_Intron|THADA_ENST00000485353.1_5'UTR|THADA_ENST00000415080.2_Missense_Mutation_p.T1063I	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1382							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AGTTCGAATGGTATTAGGAAT	0.483000													37	84					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897566	153897566	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:153897566C>T	ENST00000511601.1	+	12	3311	c.3123C>T	c.(3121-3123)gcC>gcT	p.A1041A	FHDC1_ENST00000260008.3_Silent_p.A1041A			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1041					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					ACACAGTGGCCTCCTCCTCTC	0.637000													35	93					0	0	1	0	0
CORO6	84940	broad.mit.edu	37	17	27943157	27943157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:27943157G>A	ENST00000345068.5	-	10	1312	c.1099C>T	c.(1099-1101)Cca>Tca	p.P367S	RP11-68I3.2_ENST00000581474.1_RNA|CORO6_ENST00000388767.3_Missense_Mutation_p.P367S|CORO6_ENST00000456796.3_Missense_Mutation_p.P133S|CORO6_ENST00000445145.2_Missense_Mutation_p.P367S|CORO6_ENST00000580212.1_Missense_Mutation_p.P327S|CORO6_ENST00000577909.1_5'UTR|CORO6_ENST00000584969.1_Missense_Mutation_p.P367S			Q6QEF8	CORO6_HUMAN	coronin 6	367					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						TCCGGGCCTGGCGTATCCGGG	0.662000													18	14					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52023386	52023386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52023386C>T	ENST00000346477.3	-	7	1332	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	SIGLEC6_ENST00000359982.4_3'UTR|SIGLEC6_ENST00000391797.3_3'UTR|SIGLEC6_ENST00000474054.1_5'UTR|SIGLEC6_ENST00000343300.4_3'UTR|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.E386K|CTD-3073N11.9_ENST00000598220.1_RNA|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.E438K	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	438					cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		ACCTTTGGTTCCTGAGGTTGC	0.498000													59	146					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54894350	54894350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54894350G>A	ENST00000293373.6	+	3	326	c.247G>A	c.(247-249)Gag>Aag	p.E83K	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E33K	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	83					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity	p.E83K(1)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TGAAAAAGCCGAGATAATTAG	0.383000													46	174					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15349239	15349239	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15349239G>C	ENST00000263377.2	-	20	4259	c.4038C>G	c.(4036-4038)gaC>gaG	p.D1346E		NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	1346					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GGAAATTCATGTCAATGGTAG	0.468000			T	C15orf55	lethal midline carcinoma of young people								24	88					0	0	1	0	0
TMEM205	374882	broad.mit.edu	37	19	11456054	11456054	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11456054G>A	ENST00000354882.5	-	2	564	c.138C>T	c.(136-138)ttC>ttT	p.F46F	CCDC159_ENST00000588790.1_5'UTR|TMEM205_ENST00000593256.2_Silent_p.F46F|TMEM205_ENST00000586956.1_Silent_p.F46F|TMEM205_ENST00000586218.1_5'UTR|TMEM205_ENST00000587948.1_Silent_p.F46F|TMEM205_ENST00000586590.1_Silent_p.F46F|TMEM205_ENST00000447337.1_Silent_p.F46F|TMEM205_ENST00000588560.1_Silent_p.F46F|RAB3D_ENST00000589655.1_Intron|CCDC159_ENST00000587100.1_3'UTR|TMEM205_ENST00000589555.1_Silent_p.F46F			Q6UW68	TM205_HUMAN	transmembrane protein 205	46						integral to membrane				endometrium(1)|lung(1)	2						GCACTAGTCCGAAGGTATGTC	0.552000													10	58					0	0	1	0	0
DEFB112	245915	broad.mit.edu	37	6	50016297	50016297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:50016297G>A	ENST00000322246.4	-	1	67	c.68C>T	c.(67-69)tCc>tTc	p.S23F		NM_001037498.1	NP_001032587.1	Q30KQ8	DB112_HUMAN	defensin, beta 112	23					defense response to bacterium	extracellular region				central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.042)					AAATATTGTGGAAGATGTATT	0.333000													13	60					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51749298	51749298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51749298C>T	ENST00000395052.3	+	4	1743	c.1509C>T	c.(1507-1509)ccC>ccT	p.P503P	GRM2_ENST00000442933.2_Intron|GRM2_ENST00000475478.1_3'UTR	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	503					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCAGTGAGCCCTGCCTCCAGA	0.622000													14	25					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143513864	143513864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:143513864G>A	ENST00000316549.6	-	4	720	c.512C>T	c.(511-513)gCc>gTc	p.A171V		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	171					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						GCAGGAGATGGCAGTTCCCAA	0.413000													35	77					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155148391	155148391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155148391G>A	ENST00000392451.2	+	3	436	c.353G>A	c.(352-354)cGa>cAa	p.R118Q	TRIM46_ENST00000545012.1_5'UTR|TRIM46_ENST00000368382.1_Missense_Mutation_p.R95Q|TRIM46_ENST00000468878.1_3'UTR|TRIM46_ENST00000368383.3_Missense_Mutation_p.R118Q|TRIM46_ENST00000543729.1_Missense_Mutation_p.R125Q|TRIM46_ENST00000334634.4_Missense_Mutation_p.R118Q|TRIM46_ENST00000368385.4_Missense_Mutation_p.R118Q			Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	118						intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGGAGGAAGCGAGGTGCTTTG	0.582000													90	192					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538757	55538757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55538757G>A	ENST00000220676.1	+	4	2463	c.2315G>A	c.(2314-2316)gGa>gAa	p.G772E		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	772					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGTTCAAGGACTTTTAACC	0.294000													6	46					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407199	38407199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38407199C>T	ENST00000322350.5	+	8	1444	c.1098C>T	c.(1096-1098)ggC>ggT	p.G366G	EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000336740.6_Silent_p.G132G|EGFLAM_ENST00000354891.3_Silent_p.G366G	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	366	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					CCTGGGGGGGCTCGCGATGCC	0.537000													22	50					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19184088	19184088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19184088C>T	ENST00000355377.2	+	2	420	c.22C>T	c.(22-24)Cca>Tca	p.P8S	CTD-2349B8.1_ENST00000564808.2_3'UTR|SYT17_ENST00000562034.1_5'UTR|SYT17_ENST00000568115.1_Intron|SYT17_ENST00000562711.2_Missense_Mutation_p.P4S	NM_016524.2	NP_057608.2	Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	8						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						GCAGTTGGAACCATTAAACGA	0.433000													14	59					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98744710	98744710	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98744710C>T	ENST00000477737.1	+	6	915	c.711C>T	c.(709-711)tcC>tcT	p.S237S	VWA3B_ENST00000451075.2_Silent_p.S87S|VWA3B_ENST00000435344.1_Silent_p.S237S	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	237										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AGATTGAATCCATTTACTACT	0.478000													45	125					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94204131	94204131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94204131C>T	ENST00000515393.1	-	17	2342	c.2343G>A	c.(2341-2343)atG>atA	p.M781I	MCTP1_ENST00000312216.8_Missense_Mutation_p.M560I|MCTP1_ENST00000429576.2_Missense_Mutation_p.M514I|MCTP1_ENST00000505078.1_Missense_Mutation_p.M297I|MCTP1_ENST00000505208.1_Missense_Mutation_p.M560I	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	781					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		CACAACGTTTCATTCTGATAA	0.358000													8	30					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624786	123624786	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123624786C>T	ENST00000327930.2	-	1	467	c.441G>A	c.(439-441)tgG>tgA	p.W147*		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGCCCACCACCCAGGAGCTCA	0.512000													21	83					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43708284	43708284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43708284G>A	ENST00000405312.3	-	2	421	c.184C>T	c.(184-186)Ctt>Ttt	p.L62F	PSG4_ENST00000433626.2_Missense_Mutation_p.L62F|PSG4_ENST00000244295.9_Missense_Mutation_p.L62F	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	62	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				TAGCCAGCAAGATTCTGGGGC	0.448000													29	364					0	0	1	0	0
FOXJ2	55810	broad.mit.edu	37	12	8196618	8196618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8196618C>T	ENST00000162391.3	+	5	1694	c.549C>T	c.(547-549)gcC>gcT	p.A183A	FOXJ2_ENST00000428177.2_Silent_p.A183A	NM_018416.2	NP_060886.1	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	183					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		GTGGAGAAGCCTCACTGCCTC	0.547000													31	88					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76565478	76565478	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76565478C>T	ENST00000389840.5	-	8	1300	c.1176G>A	c.(1174-1176)gtG>gtA	p.V392V	DNAH17_ENST00000585328.1_Silent_p.V392V					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCTTCATGTTCACGCAGCAGA	0.522000													7	12					0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136481641	136481641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136481641C>T	ENST00000264160.4	+	26	3449	c.3079C>T	c.(3079-3081)Cgt>Tgt	p.R1027C	R3HDM1_ENST00000409606.1_Missense_Mutation_p.R1028C|R3HDM1_ENST00000410054.1_Missense_Mutation_p.R972C|R3HDM1_ENST00000329971.3_Missense_Mutation_p.R898C|R3HDM1_ENST00000409478.1_Missense_Mutation_p.R899C	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	1027							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		CCAACCACGTCGTCACCCCCT	0.557000													32	85					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826247	43826247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43826247C>T	ENST00000389420.3	-	21	2955	c.2956G>A	c.(2956-2958)Gaa>Aaa	p.E986K	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.E140K|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E986K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	986	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CGAGACCTTTCCCCTCCTCCA	0.368000													17	83					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121785550	121785550	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121785550G>A	ENST00000261367.7	+	11	3172	c.1744G>A	c.(1744-1746)Gaa>Aaa	p.E582K	CTC-210G5.1_ENST00000510972.1_RNA|SNCAIP_ENST00000414317.2_Missense_Mutation_p.E137K|SNCAIP_ENST00000379538.3_Missense_Mutation_p.E169K|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E582K|CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000503116.2_3'UTR|CTC-210G5.1_ENST00000506053.1_RNA|CTC-210G5.1_ENST00000505546.1_RNA|CTC-210G5.1_ENST00000503529.1_RNA|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E535K|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E475K|SNCAIP_ENST00000542191.1_Missense_Mutation_p.E93K|SNCAIP_ENST00000504884.2_3'UTR			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	535					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACAAACAGTAGAACGTGTCAC	0.413000													44	148					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285576	48285576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48285576C>T	ENST00000320048.1	+	1	164	c.164C>T	c.(163-165)tCc>tTc	p.S55F		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S55F(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GTGCTCACCTCCCCCATGTAT	0.478000													23	36					0	0	1	0	0
PPM1K	152926	broad.mit.edu	37	4	89199393	89199393	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89199393G>A	ENST00000295908.6	-	2	732	c.343C>T	c.(343-345)Cag>Tag	p.Q115*	PPM1K_ENST00000513546.2_5'UTR|PPM1K_ENST00000506423.1_Nonsense_Mutation_p.Q115*|PPM1K_ENST00000315194.4_Nonsense_Mutation_p.Q115*	NM_152542.3	NP_689755.3	Q8N3J5	PPM1K_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1K	115	PP2C-like.				protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	13		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		TCTGTCAGCTGAGCGAAGTCA	0.463000													17	19					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43501528	43501528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43501528C>T	ENST00000300215.3	-	6	1323	c.866G>A	c.(865-867)cGa>cAa	p.R289Q	EPB42_ENST00000540029.1_Missense_Mutation_p.R181Q|EPB42_ENST00000441366.2_Missense_Mutation_p.R259Q			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	259					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		AGGTCGGCCTCGGCCGGTGAG	0.672000													6	57					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	51948359	51948359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:51948359G>A	ENST00000311234.4	-	15	2561	c.2089C>T	c.(2089-2091)Ctt>Ttt	p.L697F	INTS6_ENST00000490542.1_Missense_Mutation_p.L381F|INTS6_ENST00000463928.1_3'UTR|INTS6_ENST00000497989.1_Missense_Mutation_p.L519F|INTS6_ENST00000425000.1_Missense_Mutation_p.L265F|INTS6_ENST00000398119.2_Missense_Mutation_p.L684F	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	697					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		TGAAGAGGAAGAGGTTTAATA	0.358000													51	136					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11384820	11384820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:11384820C>T	ENST00000304623.8	-	7	1323	c.1134G>A	c.(1132-1134)gaG>gaA	p.E378E	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Intron|CTNND2_ENST00000511377.1_Silent_p.E287E|CTNND2_ENST00000503622.1_Intron|CTNND2_ENST00000359640.2_Silent_p.E378E	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	378					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGGCATACAGCTCCTGCGAGT	0.692000													7	12					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331897	70331897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70331897C>T	ENST00000338508.4	-	32	4503	c.4504G>A	c.(4504-4506)Gac>Aac	p.D1502N	SHANK2_ENST00000449833.2_Missense_Mutation_p.D906N|SHANK2_ENST00000423696.2_Missense_Mutation_p.D1122N|SHANK2_ENST00000409161.1_Missense_Mutation_p.D905N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1122					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AGGTGGTGGTCGCTGCTACTC	0.582000													37	24					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46086047	46086047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46086047C>T	ENST00000295452.4	-	3	444	c.277G>A	c.(277-279)Gat>Aat	p.D93N		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	93					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		ACATAAACATCAGTTTCAATT	0.299000													9	13					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154516910	154516910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154516910C>T	ENST00000368482.4	+	10	1552	c.714C>T	c.(712-714)ccC>ccT	p.P238P	TDRD10_ENST00000479937.1_3'UTR|TDRD10_ENST00000368480.3_Silent_p.P238P	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	238	Tudor.						nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCAGCAGCCCTACCTGGAGG	0.637000													4	11					0	0	1	0	0
NGRN	51335	broad.mit.edu	37	15	90814604	90814604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90814604C>T	ENST00000379095.3	+	3	468	c.460C>T	c.(460-462)Cgg>Tgg	p.R154W	RP11-697E2.6_ENST00000561573.1_3'UTR|NGRN_ENST00000331497.3_3'UTR	NM_001033088.1	NP_001028260.2	Q9NPE2	NGRN_HUMAN	neugrin, neurite outgrowth associated	154					neuron differentiation	extracellular region|nucleus				kidney(2)|large_intestine(4)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GCAGCACCTCCGGGGCTCTGG	0.493000													20	94					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	119996563	119996563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119996563G>A	ENST00000341846.5	-	4	1590	c.1169C>T	c.(1168-1170)cCc>cTc	p.P390L	TRIM29_ENST00000529044.1_Missense_Mutation_p.P129L|TRIM29_ENST00000541857.1_Missense_Mutation_p.P123L	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	390					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CAGGGGTGGGGGGAGAGAGTA	0.537000													25	63					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41559131	41559131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41559131C>T	ENST00000396942.1	-	22	2481	c.2398G>A	c.(2398-2400)Gat>Aat	p.D800N	ANK1_ENST00000352337.4_Missense_Mutation_p.D800N|ANK1_ENST00000396945.1_Missense_Mutation_p.D800N|ANK1_ENST00000289734.7_Missense_Mutation_p.D800N|ANK1_ENST00000379758.2_Missense_Mutation_p.D800N|ANK1_ENST00000265709.8_Missense_Mutation_p.D833N|ANK1_ENST00000347528.4_Missense_Mutation_p.D800N			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	800	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CGATGCTTATCACTGACTAAC	0.483000											OREG0018740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	63					0	0	1	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142542441	142542441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142542441C>T	ENST00000295992.3	-	7	1188	c.882G>A	c.(880-882)gtG>gtA	p.V294V	PCOLCE2_ENST00000485766.1_Intron	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	294						extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						GACACAAGGCCACGGTGGGTT	0.358000													32	73					0	0	1	0	0
IFLTD1	160492	broad.mit.edu	37	12	25679772	25679772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25679772C>T	ENST00000539744.1	-	5	734	c.255G>A	c.(253-255)gtG>gtA	p.V85V	IFLTD1_ENST00000445693.1_Silent_p.V119V|IFLTD1_ENST00000413632.2_Silent_p.V203V|IFLTD1_ENST00000282881.6_Silent_p.V182V|IFLTD1_ENST00000458174.2_Silent_p.V203V	NM_001256266.1	NP_001243195.1	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	182						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TTTGTCCATTCACATTTTGCT	0.368000													30	59					0	0	1	0	0
HAS1	3036	broad.mit.edu	37	19	52220436	52220436	+	Missense_Mutation	SNP	G	G	A	rs143266369	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52220436G>A	ENST00000540069.2	-	3	770	c.710C>T	c.(709-711)tCg>tTg	p.S237L	HAS1_ENST00000594621.1_Missense_Mutation_p.S92L|HAS1_ENST00000222115.1_Missense_Mutation_p.S238L|HAS1_ENST00000601714.1_Missense_Mutation_p.S245L			Q92839	HAS1_HUMAN	hyaluronan synthase 1	238					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CCTTGTGTCCGAGTCACAGAC	0.617000													20	46					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99439496	99439496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99439496G>A	ENST00000397899.2	-	7	1571	c.1240C>T	c.(1240-1242)Ccc>Tcc	p.P414S		NM_207362.2	NP_997245.2			KIAA1211-like																		TCAGTCTCGGGGGGAGTCGTG	0.721000													6	14					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110882049	110882049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110882049C>T	ENST00000265171.5	+	7	1538	c.1093C>T	c.(1093-1095)Cat>Tat	p.H365Y	EGF_ENST00000509793.1_Missense_Mutation_p.H323Y|EGF_ENST00000503392.1_Missense_Mutation_p.H365Y	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	365	EGF-like 2; calcium-binding (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TTTTTGGAATCATGGCTGTAC	0.388000													16	69					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1755118	1755118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1755118G>A	ENST00000397196.2	+	5	1012	c.780G>A	c.(778-780)aaG>aaA	p.K260K	WNT5B_ENST00000537031.1_Silent_p.K260K|WNT5B_ENST00000310594.3_Silent_p.K260K|WNT5B_ENST00000545747.1_3'UTR	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	260					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			TCACCCGCAAGGGCCGGCTGG	0.682000													17	32					0	0	1	0	0
CPT1A	1374	broad.mit.edu	37	11	68571514	68571514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68571514G>A	ENST00000265641.5	-	5	663	c.509C>T	c.(508-510)tCg>tTg	p.S170L	CPT1A_ENST00000539743.1_Missense_Mutation_p.S170L|CPT1A_ENST00000376618.2_Missense_Mutation_p.S170L|CPT1A_ENST00000540367.1_Missense_Mutation_p.S170L	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	170					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GCGAGGCAGCGATGTCTGGAA	0.498000													25	56					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81719638	81719638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81719638C>T	ENST00000550584.2	-	21	2855	c.2560G>A	c.(2560-2562)Gag>Aag	p.E854K	PPFIA2_ENST00000333447.7_Missense_Mutation_p.E836K|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Missense_Mutation_p.E836K|PPFIA2_ENST00000541570.2_Missense_Mutation_p.E421K|PPFIA2_ENST00000541017.1_Missense_Mutation_p.E71K|PPFIA2_ENST00000552948.1_Missense_Mutation_p.E854K|PPFIA2_ENST00000548586.1_Missense_Mutation_p.E854K|PPFIA2_ENST00000407050.4_Missense_Mutation_p.E780K|PPFIA2_ENST00000550359.2_Missense_Mutation_p.E701K|PPFIA2_ENST00000443686.3_Missense_Mutation_p.E755K|PPFIA2_ENST00000549396.1_Missense_Mutation_p.E854K	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	780										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GCTTCAGTCTCCATAAAGCCT	0.423000													9	36					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620296	7620296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:7620296G>A	ENST00000486284.1	+	8	1977	c.1703G>A	c.(1702-1704)aGg>aAg	p.R568K	GRM7_ENST00000357716.4_Missense_Mutation_p.R568K|GRM7_ENST00000403881.1_Missense_Mutation_p.R568K|GRM7_ENST00000402647.2_Missense_Mutation_p.R568K|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000389336.4_Missense_Mutation_p.R568K	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	568					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TATGACCAGAGGCCCAATGAA	0.522000													53	97					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179732796	179732796	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179732796G>A	ENST00000420890.2	-	16	2648	c.2531C>T	c.(2530-2532)gCc>gTc	p.A844V	CCDC141_ENST00000295723.5_Missense_Mutation_p.A269V	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	269	Ig-like.						protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TAAGGAAAGGGCCAGTCTGTG	0.522000													16	72					0	0	1	0	0
KLRD1	3824	broad.mit.edu	37	12	10464155	10464155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10464155C>T	ENST00000381908.3	+	4	516	c.256C>T	c.(256-258)Cgg>Tgg	p.R86W	KLRD1_ENST00000538997.1_3'UTR|KLRD1_ENST00000543777.1_Missense_Mutation_p.R65W|KLRD1_ENST00000350274.5_Missense_Mutation_p.R55W|KLRD1_ENST00000381907.4_Missense_Mutation_p.R86W|KLRD1_ENST00000336164.4_Missense_Mutation_p.R86W|KLRD1_ENST00000543420.1_Missense_Mutation_p.R86W			Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D, member 1	86	C-type lectin.				cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	10						GAACGAAAGTCGGCATCTCTG	0.438000													19	82					0	0	1	0	0
CA6	765	broad.mit.edu	37	1	9027799	9027799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9027799C>T	ENST00000377443.2	+	6	657	c.653C>T	c.(652-654)tCa>tTa	p.S218L	CA6_ENST00000377442.2_Missense_Mutation_p.S158L|CA6_ENST00000476083.1_3'UTR|CA6_ENST00000377436.3_Missense_Mutation_p.S218L	NM_001215.3	NP_001206.2	P23280	CAH6_HUMAN	carbonic anhydrase VI	218					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		TACCATGGCTCACTCACCACG	0.527000													32	70					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48124510	48124510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:48124510C>T	ENST00000244043.4	-	10	1479	c.1450G>A	c.(1450-1452)Ggt>Agt	p.G484S	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	484					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TGCATCAGACCGAAGCCGTAC	0.597000													13	38					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640665	34640665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34640665C>T	ENST00000537011.1	+	3	978	c.596C>T	c.(595-597)cCc>cTc	p.P199L	NUTM1_ENST00000438749.3_Missense_Mutation_p.P189L|NUTM1_ENST00000333756.4_Missense_Mutation_p.P171L					NUT midline carcinoma, family member 1																		CAACTGGTCCCCATTGTGCCC	0.602000													14	30					0	0	1	0	0
ZNF20	7568	broad.mit.edu	37	19	12243696	12243696	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12243696G>A	ENST00000334213.5	-	4	1529	c.1305C>T	c.(1303-1305)ttC>ttT	p.F435F	ZNF20_ENST00000600335.1_Intron|ZNF625-ZNF20_ENST00000430024.1_3'UTR	NM_001203250.1|NM_021143.3	NP_001190179.1|NP_066966.2	P17024	ZNF20_HUMAN	zinc finger protein 20	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|lung(6)	8						GCAAGGAAGAGAAATACCTGA	0.408000													21	68					0	0	1	0	0
FAM135A	57579	broad.mit.edu	37	6	71269569	71269569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:71269569C>T	ENST00000418814.2	+	22	5107	c.4493C>T	c.(4492-4494)tCg>tTg	p.S1498L	FAM135A_ENST00000370479.3_Missense_Mutation_p.S1285L|FAM135A_ENST00000361499.3_Missense_Mutation_p.S1302L|FAM135A_ENST00000505769.1_Missense_Mutation_p.S1078L|FAM135A_ENST00000457062.2_Missense_Mutation_p.S1285L	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	1498										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						GTTCTTGATTCGGAAATATTT	0.373000													20	22					0	0	1	0	0
WFDC8	90199	broad.mit.edu	37	20	44184463	44184463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44184463C>T	ENST00000357199.4	-	4	400	c.322G>A	c.(322-324)Gca>Aca	p.A108T	WFDC8_ENST00000289953.2_Missense_Mutation_p.A108T	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	108	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				CAGCGCTGTGCCTCATGATTA	0.463000													26	76					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2705137	2705137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2705137G>A	ENST00000399655.1	+	20	3026	c.2761G>A	c.(2761-2763)Gac>Aac	p.D921N	CACNA1C_ENST00000399637.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000480911.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000335762.5_Missense_Mutation_p.D946N|CACNA1C_ENST00000399603.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399649.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399595.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399606.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399601.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399617.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000344100.3_Missense_Mutation_p.D921N|CACNA1C_ENST00000399621.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399629.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000327702.7_Missense_Mutation_p.D921N|CACNA1C_ENST00000406454.3_Missense_Mutation_p.D921N|CACNA1C_ENST00000402845.3_Missense_Mutation_p.D921N|CACNA1C_ENST00000399597.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000347598.4_Missense_Mutation_p.D921N|CACNA1C_ENST00000399641.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399638.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399644.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399591.1_Missense_Mutation_p.D921N|CACNA1C_ENST00000399634.1_Missense_Mutation_p.D921N	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	921					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGCTGCTGAGGACCCGGTCCA	0.572000													21	70					0	0	1	0	0
LCN9	392399	broad.mit.edu	37	9	138556088	138556088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138556088C>T	ENST00000277526.3	+	2	177	c.177C>T	c.(175-177)ttC>ttT	p.F59F	LCN9_ENST00000430290.2_3'UTR	NM_001001676.1	NP_001001676.1	Q8WX39	LCN9_HUMAN	lipocalin 9	59						extracellular region	pheromone binding|transporter activity			kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	6		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		TGAGGGTCTTCGTCCGGAATA	0.468000													18	75					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72975151	72975151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:72975151C>T	ENST00000521978.1	+	21	3253	c.3253C>T	c.(3253-3255)Cat>Tat	p.H1085Y	RIMS1_ENST00000348717.5_Intron|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000538414.1_Intron|RIMS1_ENST00000517960.1_Intron|RIMS1_ENST00000491071.2_Intron|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000401910.3_Intron|RIMS1_ENST00000425662.2_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000264839.7_Intron|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000518273.1_Intron	NM_014989.5	NP_055804.2	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1085					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.H1085N(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CATTTCCCTTCATCATGAATG	0.323000													5	46					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039053	11039053	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039053C>T	ENST00000470054.1	-	0	1150									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGAGTCCATCAATCCAGTAG	0.383000													35	740					0	0	1	0	0
RAB9BP1	9366	broad.mit.edu	37	5	104435182	104435182	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:104435182G>A	ENST00000522464.1	-	0	68				RP11-6N13.1_ENST00000503650.1_lincRNA																							TTAACGGCAGGAAAATCATCA	0.358000													10	35					0	0	1	0	0
PGC	5225	broad.mit.edu	37	6	41704679	41704679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41704679G>A	ENST00000373025.3	-	9	1140	c.1078C>T	c.(1078-1080)Ctg>Ttg	p.L360L		NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	360					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			AGGATCCACAGGGGCTGGCCG	0.562000													20	57					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10755639	10755639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10755639G>A	ENST00000416569.2	-	3	1775	c.1749C>T	c.(1747-1749)ccC>ccT	p.P583P	XKR6_ENST00000304437.2_Silent_p.P304P	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	583						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		TCTTAATGAGGGGCCCTTCTG	0.512000													13	39					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53839141	53839141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53839141C>T	ENST00000288139.3	+	46	5895	c.5777C>T	c.(5776-5778)cCa>cTa	p.P1926L	CACNA1D_ENST00000544977.1_Missense_Mutation_p.P285L|CACNA1D_ENST00000422281.2_Missense_Mutation_p.P1882L|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P1906L	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1906					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CGGAGATCTCCAAGGAGACGC	0.572000													46	84					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35806986	35806986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35806986G>A	ENST00000440995.2	+	35	5173	c.5173G>A	c.(5173-5175)Ggg>Agg	p.G1725R	SPEF2_ENST00000303129.4_Missense_Mutation_p.G527R|SPEF2_ENST00000356031.3_Missense_Mutation_p.G1730R|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1730					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTGTTCAAAGGGGGAAGTGA	0.393000													26	58					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43547321	43547321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43547321G>A	ENST00000400427.1	+	18	4063	c.3667G>A	c.(3667-3669)Gac>Aac	p.D1223N	UMODL1_ENST00000400424.1_Missense_Mutation_p.D1095N|UMODL1_ENST00000400423.2_3'UTR|UMODL1_ENST00000408910.2_Missense_Mutation_p.D1167N|UMODL1_ENST00000408989.2_Missense_Mutation_p.D1295N	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	1167	ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CAACGCCCGGGACCCCATCAC	0.567000													16	65					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142231686	142231686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142231686G>A	ENST00000519067.1	-	2	570	c.267C>T	c.(265-267)ggC>ggT	p.G89G	SLC45A4_ENST00000433583.2_Silent_p.G82G|SLC45A4_ENST00000024061.3_Silent_p.G89G|SLC45A4_ENST00000517878.1_Silent_p.G140G			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	140					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CGATGGCAGAGCCGTTAAGGA	0.607000													20	65					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87082389	87082389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87082389G>A	ENST00000265723.4	-	6	518	c.407C>T	c.(406-408)tCa>tTa	p.S136L	ABCB4_ENST00000358400.3_Missense_Mutation_p.S136L|ABCB4_ENST00000545634.1_Missense_Mutation_p.S136L|ABCB4_ENST00000359206.3_Missense_Mutation_p.S136L|ABCB4_ENST00000453593.1_Missense_Mutation_p.S136L	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	136	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGTCCAAAATGAAACTTGTAT	0.388000													35	90					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71200008	71200008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:71200008G>A	ENST00000554752.2	-	11	2077	c.2078C>T	c.(2077-2079)tCa>tTa	p.S693L	MAP3K9_ENST00000554146.1_Missense_Mutation_p.S421L|MAP3K9_ENST00000553414.1_Missense_Mutation_p.S426L|MAP3K9_ENST00000555993.2_Missense_Mutation_p.S707L|MAP3K9_ENST00000381250.4_Missense_Mutation_p.S670L			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	693					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		ctggctgggtgaatgctgtag	0.552000													10	24					0	0	1	0	0
C14orf159	80017	broad.mit.edu	37	14	91647573	91647573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91647573G>A	ENST00000518868.1	+	11	1464	c.774G>A	c.(772-774)atG>atA	p.M258I	C14orf159_ENST00000521077.2_Missense_Mutation_p.M258I|C14orf159_ENST00000520328.1_Missense_Mutation_p.M241I|C14orf159_ENST00000256324.10_Missense_Mutation_p.M258I|C14orf159_ENST00000412671.2_Missense_Mutation_p.M258I|C14orf159_ENST00000428926.2_Missense_Mutation_p.M253I|C14orf159_ENST00000523771.1_Missense_Mutation_p.M253I|C14orf159_ENST00000522322.1_Missense_Mutation_p.M253I|C14orf159_ENST00000525393.2_Missense_Mutation_p.M129I|C14orf159_ENST00000523816.1_Missense_Mutation_p.M253I			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	253						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		GCACAGTTATGACTGACCTGA	0.542000													20	35					0	0	1	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206950	142206950	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142206950C>T	ENST00000426318.2	-	0	61																											GAAGAAGAGCCTGGTGCCCAT	0.552000													13	39					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683514	159683514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159683514G>A	ENST00000255030.5	-	2	579	c.476C>T	c.(475-477)tCc>tTc	p.S159F	CRP_ENST00000368111.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000368110.1_Intron|CRP_ENST00000437342.1_5'UTR|CRP_ENST00000473196.1_5'UTR	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	159	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	CCCACCGAAGGAATCCTGCTC	0.522000													125	339					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	130984529	130984529	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130984529G>A	ENST00000341179.7	+	7	995	c.903G>A	c.(901-903)caG>caA	p.Q301Q	DNM1_ENST00000475805.1_Silent_p.Q301Q|DNM1_ENST00000486160.1_Silent_p.Q301Q|DNM1_ENST00000372923.3_Silent_p.Q301Q|DNM1_ENST00000393594.3_Silent_p.Q301Q	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	301					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						ACAAGCTGCAGAGCCAGCTAC	0.597000													26	90					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149460541	149460541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149460541C>T	ENST00000286301.3	-	3	387	c.96G>A	c.(94-96)gtG>gtA	p.V32V	CSF1R_ENST00000543093.1_Silent_p.V32V	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	32	Ig-like C2-type 1.		V -> G (in dbSNP:rs56048668).		cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CTCCTGGCTTCACGACCAGCT	0.602000													10	13					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7576563	7576563	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7576563G>A	ENST00000379802.3	+	19	3008	c.2667G>A	c.(2665-2667)agG>agA	p.R889R	DSP_ENST00000418664.2_Silent_p.R889R	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	889	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGCAATTGAGGAATTATCGTG	0.373000													32	71					0	0	1	0	0
VILL	50853	broad.mit.edu	37	3	38045833	38045833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38045833C>T	ENST00000283713.6	+	16	2159	c.1893C>T	c.(1891-1893)ttC>ttT	p.F631F	VILL_ENST00000465644.1_Silent_p.F349F|VILL_ENST00000383759.2_Silent_p.F631F			O15195	VILL_HUMAN	villin-like	631					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AAGTGGGGTTCTTCAGCCAGG	0.622000											OREG0015475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	44					0	0	1	0	0
OR5M11	219487	broad.mit.edu	37	11	56310108	56310108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56310108G>A	ENST00000528616.2	-	1	649	c.626C>T	c.(625-627)tCc>tTc	p.S209F		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						GATGGTGAGGGAGCTGGAGAG	0.502000													6	59					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51054558	51054558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51054558C>T	ENST00000441560.2	+	3	525	c.44C>T	c.(43-45)tCg>tTg	p.S15L	ATL1_ENST00000354525.4_Missense_Mutation_p.S15L|ATL1_ENST00000357032.3_Missense_Mutation_p.S15L|ATL1_ENST00000556478.2_3'UTR|ATL1_ENST00000358385.6_Missense_Mutation_p.S15L	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	15					axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						GGTGGATTTTCGGAAAAGACA	0.433000													26	61					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15410457	15410457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:15410457C>T	ENST00000341776.2	+	3	428	c.184C>T	c.(184-186)Ctc>Ttc	p.L62F	JARID2_ENST00000397311.3_5'UTR|JARID2_ENST00000541660.1_Missense_Mutation_p.L24F	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	62					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				ACCTGTAGGGCTCCTTGGTAA	0.463000													33	82					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34554765	34554765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34554765G>A	ENST00000373381.4	-	2	393	c.217C>T	c.(217-219)Ccc>Tcc	p.P73S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	33	CUB 1.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTCCCATTGGGACCGTGCAGT	0.532000													14	31					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120474838	120474838	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:120474838C>T	ENST00000355622.6	+	3	533	c.432C>T	c.(430-432)ttC>ttT	p.F144F	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.F104F	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	144					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TAGAGAACTTCCCCATTGGAC	0.408000													30	74					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55381392	55381392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55381392G>A	ENST00000398661.2	-	5	528	c.397C>T	c.(397-399)Cac>Tac	p.H133Y	HMGCLL1_ENST00000428842.1_Intron|HMGCLL1_ENST00000370850.2_Intron|HMGCLL1_ENST00000508459.1_Intron|HMGCLL1_ENST00000274901.4_Missense_Mutation_p.H103Y|HMGCLL1_ENST00000308161.4_Intron	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	133							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACTTCAGTGTGATCAGCCATC	0.363000													22	83					0	0	1	0	0
MRAP	56246	broad.mit.edu	37	21	33684082	33684082	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:33684082G>A	ENST00000399784.2	+	5	481	c.294G>A	c.(292-294)agG>agA	p.R98R	MRAP_ENST00000303645.5_Silent_p.R98R|MRAP_ENST00000399786.3_Intron|MRAP_ENST00000497833.1_3'UTR|MRAP_ENST00000339944.4_Intron|URB1_ENST00000382751.3_3'UTR	NM_178817.3	NP_848932.1	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	98					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			endometrium(1)|large_intestine(2)|lung(3)	6						CGTGCCACAGGGAACCCCTGG	0.632000													41	63					0	0	1	0	0
DGCR5	26220	broad.mit.edu	37	22	18979327	18979327	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18979327C>T	ENST00000438934.1	+	0	2678				DGCR5_ENST00000440005.2_RNA																							TTCTTGACCTCAGGCTGCCTC	0.547000													3	7					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450029	105450029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105450029G>A	ENST00000337685.2	+	5	1389	c.604G>A	c.(604-606)Gat>Aat	p.D202N	MUM1L1_ENST00000372552.1_Missense_Mutation_p.D202N|MUM1L1_ENST00000357175.2_Missense_Mutation_p.D202N	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	202										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						ACTTTCGGAAGATAATGATGA	0.383000													4	12					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14819258	14819258	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14819258C>T	ENST00000380881.4	-	15	3338	c.2523G>A	c.(2521-2523)tgG>tgA	p.W841*	FREM1_ENST00000422223.2_Nonsense_Mutation_p.W840*|FREM1_ENST00000380880.3_Nonsense_Mutation_p.W840*			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	840					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GGAGATCGCCCCAAGAAAATG	0.428000													16	30					0	0	1	0	0
DEF6	50619	broad.mit.edu	37	6	35289050	35289050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35289050C>T	ENST00000316637.5	+	11	1764	c.1759C>T	c.(1759-1761)Cgc>Tgc	p.R587C	DEF6_ENST00000542066.1_Missense_Mutation_p.R332C	NM_022047.3	NP_071330.3	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog (mouse)	587						cytoplasm|nucleus|plasma membrane				cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	15						GCGCCTGACCCGCTGGGGATC	0.642000													57	140					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331606	70331606	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70331606G>A	ENST00000338508.4	-	32	4794	c.4795C>T	c.(4795-4797)Cag>Tag	p.Q1599*	SHANK2_ENST00000449833.2_Nonsense_Mutation_p.Q1003*|SHANK2_ENST00000423696.2_Nonsense_Mutation_p.Q1219*|SHANK2_ENST00000409161.1_Nonsense_Mutation_p.Q1002*			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1219					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GTCCTTGGCTGGAGAACCTTG	0.577000													34	108					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72023549	72023549	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72023549G>A	ENST00000355327.3	+	10	1757	c.1623G>A	c.(1621-1623)agG>agA	p.R541R	THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000357769.4_Silent_p.R181R|THSD4_ENST00000261862.6_Silent_p.R541R			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	541						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CACCCCACAGGAGACCAGGTA	0.557000											OREG0023247	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	76					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89735049	89735049	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89735049C>T	ENST00000343435.5	-	3	726	c.190_splice	c.e3+1	p.G64_splice	GBP5_ENST00000370459.3_Splice_Site_p.G64_splice|RP4-620F22.2_ENST00000437128.1_RNA	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	64						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		TACCACTCACCCTTGTTCTTC	0.507000													49	113					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104164979	104164979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104164979G>A	ENST00000020673.5	-	13	2884	c.2358C>T	c.(2356-2358)ttC>ttT	p.F786F	PSD_ENST00000406432.1_Silent_p.F786F	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	786	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGATCCCGTGGAAGCTCTTCC	0.667000													41	57					0	0	1	0	0
HFE2	148738	broad.mit.edu	37	1	145415632	145415632	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145415632G>A	ENST00000336751.5	+	3	689	c.451G>A	c.(451-453)Gaa>Aaa	p.E151K	HFE2_ENST00000357836.5_Missense_Mutation_p.E38K|HFE2_ENST00000497365.1_Intron|HFE2_ENST00000475797.1_Intron	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	151					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTGTGACTATGAAGGCCGGTT	0.697000													8	35					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170148796	170148796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170148796C>T	ENST00000263816.3	-	7	1021	c.736G>A	c.(736-738)Gac>Aac	p.D246N	LRP2_ENST00000443831.1_Missense_Mutation_p.D246N	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	246	LDL-receptor class A 6.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCTTTACAGTCATCTTCTCCA	0.438000													27	85					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587646	55587646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55587646G>A	ENST00000333976.4	+	1	561	c.541G>A	c.(541-543)Gag>Aag	p.E181K		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CTTCTTCTGTGAGTTCTCCTC	0.428000													46	135					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132277224	132277224	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132277224C>T	ENST00000438378.2	+	0	2293					NR_026922.1																						TCCTTACGCCCCTGGGGCGGT	0.622000													6	23					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64589979	64589979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64589979G>A	ENST00000498707.1	-	24	3845	c.3503C>T	c.(3502-3504)cCc>cTc	p.P1168L	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.P1140L	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1168					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGCAGCTGGGGGAGGATGACA	0.478000													33	68					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32751184	32751184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32751184C>T	ENST00000333070.4	+	13	1587	c.1487C>T	c.(1486-1488)cCa>cTa	p.P496L	LCK_ENST00000336890.5_Missense_Mutation_p.P466L|LCK_ENST00000373564.3_Missense_Mutation_p.P473L	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	466	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GACAACTGTCCAGAGGAGCTG	0.592000			T	TRB@	T-ALL								15	74					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971650	96971650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96971650C>T	ENST00000341686.3	+	6	896	c.771C>T	c.(769-771)ctC>ctT	p.L257L	C10orf129_ENST00000430183.1_Silent_p.L102L|C10orf129_ENST00000394005.3_Silent_p.L257L	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	257					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GGATGGATCTCCAGCCAACAG	0.473000													18	37					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50713817	50713817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50713817C>T	ENST00000440075.2	+	2	242	c.195C>T	c.(193-195)ttC>ttT	p.F65F	MYH14_ENST00000425460.1_Silent_p.F65F|MYH14_ENST00000376970.2_Silent_p.F65F|MYH14_ENST00000596571.1_Silent_p.F65F|MYH14_ENST00000598205.1_Silent_p.F65F|MYH14_ENST00000262269.8_Silent_p.F65F|MYH14_ENST00000601313.1_Silent_p.F65F			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	65	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		TTCACGGGTTCGAGGCGGCGG	0.761000													4	6					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74011530	74011530	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74011530C>T	ENST00000301607.3	-	15	2143		c.e15+1		EVPL_ENST00000586740.1_Splice_Site	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin						keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						AGAGCACTCACTTCTCCCCGT	0.667000													11	82					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99514879	99514879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:99514879G>A	ENST00000261037.3	+	5	2514	c.2134G>A	c.(2134-2136)Gac>Aac	p.D712N	COL8A1_ENST00000273342.4_Missense_Mutation_p.D712N	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	712	C1q.|Nonhelical region (NC1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						CAGGCCCGGAGACCGGGTGTT	0.537000													20	42					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141542669	141542669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:141542669G>A	ENST00000220592.5	-	18	2429	c.2317C>T	c.(2317-2319)Cgt>Tgt	p.R773C	AGO2_ENST00000519980.1_Missense_Mutation_p.R739C	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		GAGGAGAAACGATTGTCGTCC	0.517000													21	42					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110418764	110418764	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110418764C>T	ENST00000360185.4	-	7	875	c.711G>A	c.(709-711)agG>agA	p.R237R	GIT2_ENST00000343646.5_Silent_p.R237R|GIT2_ENST00000551209.1_Silent_p.R237R|GIT2_ENST00000356259.4_Silent_p.R237R|GIT2_ENST00000457474.2_Silent_p.R237R|TCHP_ENST00000550780.1_3'UTR|GIT2_ENST00000354574.4_Silent_p.R237R|GIT2_ENST00000553118.1_Silent_p.R237R|GIT2_ENST00000355312.3_Silent_p.R237R|GIT2_ENST00000338373.5_Silent_p.R237R|GIT2_ENST00000320063.9_Silent_p.R237R|GIT2_ENST00000547815.1_Silent_p.R237R|GIT2_ENST00000361006.5_Silent_p.R237R			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	237					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						CACCTGGTTTCCTGCCACAGA	0.488000													70	254					0	0	1	0	0
SEPW1	6415	broad.mit.edu	37	19	48284381	48284381	+	Missense_Mutation	SNP	C	C	T	rs11551813		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48284381C>T	ENST00000601048.1	+	4	339	c.125C>T	c.(124-126)cCc>cTc	p.P42L	SEPW1_ENST00000595615.1_Missense_Mutation_p.P42L|SEPW1_ENST00000593892.1_Missense_Mutation_p.P42L|SEPW1_ENST00000509570.2_Missense_Mutation_p.P43L|SEPW1_ENST00000601419.1_3'UTR	NM_003009.2	NP_003000.1	P63302	SELW_HUMAN	selenoprotein W, 1	42					cell redox homeostasis	cytoplasm	selenium binding			endometrium(1)|kidney(1)|lung(2)	4		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		all cancers(93;0.000291)|OV - Ovarian serous cystadenocarcinoma(262;0.000305)|Epithelial(262;0.0146)|GBM - Glioblastoma multiforme(486;0.0273)		GAGGGAACTCCCCAGGCCACC	0.572000													39	227					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132534831	132534831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132534831C>T	ENST00000265342.7	-	16	2734	c.2485G>A	c.(2485-2487)Ggt>Agt	p.G829S	CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	829						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCTTTATACCTGACACCTCA	0.592000													11	43					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141535653	141535653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141535653C>T	ENST00000264952.2	+	4	1560	c.1423C>T	c.(1423-1425)Cct>Tct	p.P475S		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	475	AGC-kinase C-terminal.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						TGTGCCAGACCCTTCAGTGGT	0.428000													49	219					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38889214	38889214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38889214C>T	ENST00000302328.3	-	26	4545	c.4347G>A	c.(4345-4347)ttG>ttA	p.L1449L	SCN11A_ENST00000456224.3_Silent_p.L1411L|SCN11A_ENST00000450244.1_Silent_p.L1449L	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1449					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCTGATTTTCCAAGGTAGAAA	0.502000													4	36					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725888	140725888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140725888C>T	ENST00000253812.6	+	1	2288	c.2288C>T	c.(2287-2289)tCg>tTg	p.S763L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCGGACTCGCGGAAGAGC	0.612000													39	206					0	0	1	0	0
TRAPPC8	22878	broad.mit.edu	37	18	29493334	29493334	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29493334G>A	ENST00000283351.4	-	5	1104	c.769C>T	c.(769-771)Cag>Tag	p.Q257*	TRAPPC8_ENST00000582539.1_Nonsense_Mutation_p.Q203*|TRAPPC8_ENST00000582513.1_Nonsense_Mutation_p.Q257*	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	257					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ACATATACCTGGTTTTGAATA	0.294000													8	61					0	0	1	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142537228	142537228	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142537228G>A	ENST00000295992.3	-	9	1503	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	PCOLCE2_ENST00000485766.1_3'UTR	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	399	NTR.					extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						TCTTGGTCTTGAACATCATGA	0.378000													32	84					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85540643	85540643	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85540643C>T	ENST00000295887.5	+	5	960	c.537C>T	c.(535-537)ctC>ctT	p.L179L		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	179					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		TTCAGTTCCTCATTCGCTACC	0.313000													18	86					0	0	1	0	0
GLTPD1	80772	broad.mit.edu	37	1	1262938	1262938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1262938C>T	ENST00000343938.4	+	3	851	c.440C>T	c.(439-441)gCc>gTc	p.A147V	GLTPD1_ENST00000464957.1_3'UTR	NM_001029885.1	NP_001025056.1	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	147						cytoplasm	glycolipid binding|glycolipid transporter activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCCTCGCTGGCCGCCTACCAC	0.721000													3	10					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25150797	25150797	+	Missense_Mutation	SNP	G	G	A	rs142590557		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25150797G>A	ENST00000332271.5	-	7	1143	c.727C>T	c.(727-729)Cgc>Tgc	p.R243C	PIWIL3_ENST00000533313.1_Missense_Mutation_p.R134C|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.R134C	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	243					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding	p.R243C(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TAATAGTTGCGACCAACTTGT	0.348000													32	98					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37406712	37406712	+	Nonsense_Mutation	SNP	G	G	A	rs147099571		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37406712G>A	ENST00000535679.1	-	4	417	c.418C>T	c.(418-420)Cga>Tga	p.R140*	SULT6B1_ENST00000379149.2_Intron|SULT6B1_ENST00000260637.3_Nonsense_Mutation_p.R102*|SULT6B1_ENST00000407963.1_Nonsense_Mutation_p.R102*			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	140						cytoplasm	sulfotransferase activity	p.R102>?(1)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				TTAGGGTTTCGAAATATCACC	0.358000													49	87					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936779	15936779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:15936779G>A	ENST00000504595.1	+	4	1441	c.960G>A	c.(958-960)gtG>gtA	p.V320V	FBXL7_ENST00000329673.7_Silent_p.V308V|FBXL7_ENST00000510662.1_Silent_p.V273V	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	320					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GCTACCTGGTGATCTACTGCG	0.672000													8	25					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37494459	37494459	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37494459C>A	ENST00000381792.2	-	3	473	c.333G>T	c.(331-333)aaG>aaT	p.K111N	TMPRSS6_ENST00000406725.1_Missense_Mutation_p.K111N|TMPRSS6_ENST00000406856.1_Missense_Mutation_p.K111N|TMPRSS6_ENST00000346753.3_Missense_Mutation_p.K120N|TMPRSS6_ENST00000442782.2_Missense_Mutation_p.K120N			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	120					angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						TTCCTACCATCTTCTGGGCTT	0.557000													121	283					4.38229e-66	4.41454e-66	1	1	0
MYO7B	4648	broad.mit.edu	37	2	128324308	128324308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128324308C>T	ENST00000389524.4	+	5	429	c.376C>T	c.(376-378)Cat>Tat	p.H126Y	MYO7B_ENST00000428314.1_Missense_Mutation_p.H126Y|MYO7B_ENST00000409816.2_Missense_Mutation_p.H126Y			Q6PIF6	MYO7B_HUMAN	myosin VIIB	126	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTACAGCCGCCATATGGGCGA	0.582000													7	24					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7846792	7846792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7846792G>A	ENST00000328375.1	-	1	727	c.728C>T	c.(727-729)tCc>tTc	p.S243F	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGTGAGGTGGGAGGTGCAGGT	0.507000													22	88					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642485	57642485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57642485G>A	ENST00000254181.4	+	4	2896	c.2442G>A	c.(2440-2442)gtG>gtA	p.V814V	USP29_ENST00000598197.1_Silent_p.V814V	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	814					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAAGAAACGTGAAGATGGGGG	0.478000													16	29					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229772297	229772297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:229772297C>T	ENST00000258243.2	+	4	2073	c.1937C>T	c.(1936-1938)tCg>tTg	p.S646L		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	646						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						AACCTCCCTTCGTTGCTCCCA	0.478000													79	255					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231077635	231077635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231077635G>A	ENST00000258381.6	-	4	501	c.424C>T	c.(424-426)Cca>Tca	p.P142S	SP110_ENST00000258382.5_Missense_Mutation_p.P142S|SP110_ENST00000338556.3_5'UTR|SP110_ENST00000540870.1_Missense_Mutation_p.P148S|SP110_ENST00000358662.4_Missense_Mutation_p.P142S|SP110_ENST00000392048.3_Missense_Mutation_p.P142S	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	142					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		GGGGGTTGTGGTGGGGGCAGC	0.577000													35	120					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54914924	54914924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54914924G>A	ENST00000293373.6	+	18	1859	c.1780G>A	c.(1780-1782)Ggt>Agt	p.G594S	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.G544S	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	594					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CAAGAACCATGGTCTTCACCA	0.537000													12	108					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50781389	50781389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50781389C>T	ENST00000440075.2	+	30	3922	c.3875C>T	c.(3874-3876)tCc>tTc	p.S1292F	MYH14_ENST00000425460.1_Missense_Mutation_p.S1259F|MYH14_ENST00000376970.2_Missense_Mutation_p.S1284F|MYH14_ENST00000598205.1_Missense_Mutation_p.S1259F|MYH14_ENST00000596571.1_Missense_Mutation_p.S1251F|MYH14_ENST00000262269.8_Missense_Mutation_p.S1292F|MYH14_ENST00000601313.1_Missense_Mutation_p.S1292F			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1251					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCCGAGGTGTCCGAGCTGCGG	0.647000													6	29					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62943454	62943454	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:62943454C>A	ENST00000393630.3	+	24	3154	c.2763C>A	c.(2761-2763)tcC>tcA	p.S921S	MON2_ENST00000280379.6_Silent_p.S921S|MON2_ENST00000552738.1_Silent_p.S897S|MON2_ENST00000393629.2_Silent_p.S920S|MON2_ENST00000552115.1_Silent_p.S920S|MON2_ENST00000393632.2_Silent_p.S920S|MON2_ENST00000546600.1_Silent_p.S920S	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	921					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TCAGAGAATCCTTGATACGAA	0.378000													14	103					1.15088e-07	1.15424e-07	1	1	0
SLC22A25	387601	broad.mit.edu	37	11	62996844	62996844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62996844G>A	ENST00000306494.6	-	1	280	c.281C>T	c.(280-282)cCc>cTc	p.P94L	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	94					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CTTCCACTGGGGATGGACAAA	0.542000													15	82					0	0	1	0	0
FAM133A	286499	broad.mit.edu	37	X	92964696	92964696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:92964696G>A	ENST00000538690.1	+	5	839	c.278G>A	c.(277-279)aGa>aAa	p.R93K	FAM133A_ENST00000332647.4_Missense_Mutation_p.R93K|FAM133A_ENST00000355813.5_Missense_Mutation_p.R93K|FAM133A_ENST00000322139.4_Missense_Mutation_p.R93K	NM_001171110.1	NP_001164581.1	Q8N9E0	F133A_HUMAN	family with sequence similarity 133, member A	93	Lys-rich.|Ser-rich.									breast(2)|endometrium(2)|large_intestine(8)|lung(7)|upper_aerodigestive_tract(1)	20						aaaagagaaagaaagaaaaag	0.318000													11	9					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32562460	32562460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:32562460C>T	ENST00000345122.3	+	2	2900	c.2585C>T	c.(2584-2586)tCg>tTg	p.S862L	ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.S862L|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000556611.1_Missense_Mutation_p.S862L|ARHGAP5_ENST00000539826.2_Missense_Mutation_p.S862L	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	862					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CGGAAAGCTTCGATGGGAATG	0.378000													17	52					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14792844	14792844	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14792844G>A	ENST00000261170.3	-	19	2245	c.2109C>T	c.(2107-2109)ccC>ccT	p.P703P		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	703	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						CTGGGCGGAAGGGTTTCATTC	0.368000													7	125					0	0	1	0	0
DUS3L	56931	broad.mit.edu	37	19	5785466	5785466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5785466G>A	ENST00000309061.7	-	12	1904	c.1808C>T	c.(1807-1809)cCc>cTc	p.P603L	DUS3L_ENST00000320699.8_Missense_Mutation_p.P361L|CTB-54O9.9_ENST00000586012.1_Missense_Mutation_p.P25L	NM_020175.2	NP_064560.2	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like (S. cerevisiae)	603					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(2)	14						CAGGTAGTAGGGCGGCCGCTC	0.682000													4	5					0	0	1	0	0
FAM9A	171482	broad.mit.edu	37	X	8763148	8763148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:8763148C>T	ENST00000543214.1	-	7	937	c.802G>A	c.(802-804)Gaa>Aaa	p.E268K	FAM9A_ENST00000381003.3_Missense_Mutation_p.E268K	NM_001171186.1	NP_001164657.1	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	268	Glu-rich.					nucleolus				endometrium(11)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	18		Hepatocellular(5;0.219)				tcttcttcttcttcctcttcc	0.418000													11	9					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135561028	135561028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135561028C>T	ENST00000513104.1	-	10	2559	c.2277G>A	c.(2275-2277)caG>caA	p.Q759Q	TRPC7_ENST00000355180.3_Silent_p.Q698Q|TRPC7_ENST00000426057.2_Silent_p.Q643Q	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	759					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCATGCCAGCCTGGTAGCGAG	0.453000													10	18					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544548	186544548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186544548C>T	ENST00000431808.1	-	14	2586	c.2023G>A	c.(2023-2025)Gaa>Aaa	p.E675K	SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.E579K|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.E775K|SORBS2_ENST00000284776.7_Missense_Mutation_p.E675K|SORBS2_ENST00000319471.9_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	675						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CTGGCTCTTTCGTGTTTTAAC	0.542000													23	162					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814350	60814350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60814350C>T	ENST00000544856.2	-	7	1254	c.876G>A	c.(874-876)gaG>gaA	p.E292E	RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000456609.2_Silent_p.E293E|MARCH10_ENST00000311269.5_Silent_p.E293E|MARCH10_ENST00000583600.1_Silent_p.E331E|RP11-156L14.1_ENST00000582564.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	293							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						ACTGGGTTTCCTCTTCAGTGT	0.478000													37	431					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57115230	57115230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:57115230C>T	ENST00000439986.4	-	7	797	c.760G>A	c.(760-762)Ggc>Agc	p.G254S	CCBE1_ENST00000398179.2_Silent_p.G29G	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	254	Collagen-like 1.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				GGGCCCTGGCCCCCAGGCAGG	0.582000													39	90					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56031521	56031521	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56031521C>T	ENST00000309675.2	+	1	878	c.846C>T	c.(844-846)atC>atT	p.I282I		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						ACACAGTCATCACACCCATGC	0.582000													17	69					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124117716	124117716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124117716G>A	ENST00000360013.3	+	13	2465	c.2338G>A	c.(2338-2340)Gag>Aag	p.E780K	KALRN_ENST00000240874.3_Missense_Mutation_p.E780K|KALRN_ENST00000460856.1_Missense_Mutation_p.E780K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	780					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GTACACCATCGAGGTAGCAGG	0.592000													5	55					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15571068	15571068	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15571068C>T	ENST00000343625.6	-	6	688	c.606_splice	c.e6-1	p.G203_splice		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	203	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						CTTGAGCAACCCCTGTGGGGA	0.572000													5	13					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085580	9085580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9085580C>T	ENST00000397910.4	-	1	6438	c.6235G>A	c.(6235-6237)Ggg>Agg	p.G2079R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2079	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.G2079W(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTGAAACCCCAGAATGGCCT	0.473000													54	113					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23600749	23600749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23600749G>A	ENST00000316902.7	-	8	1759	c.1034C>T	c.(1033-1035)gCc>gTc	p.A345V	SLC7A8_ENST00000529705.2_Missense_Mutation_p.A240V|SLC7A8_ENST00000453702.1_Missense_Mutation_p.A142V|SLC7A8_ENST00000469263.1_Intron|SLC7A8_ENST00000422941.2_Missense_Mutation_p.A121V	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	345					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	GCCCTCTCGGGCTCCAGCGAA	0.602000													10	35					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15586491	15586491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15586491G>A	ENST00000292609.4	-	2	1119	c.990C>T	c.(988-990)tcC>tcT	p.S330S	PGLYRP2_ENST00000340880.4_Silent_p.S330S			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	330					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GGGCCAGGATGGAGGCTGAAG	0.617000													16	40					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398676	89398676	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89398676C>T	ENST00000439576.2	+	12	3234	c.2860C>T	c.(2860-2862)Ctc>Ttc	p.L954F	ACAN_ENST00000559004.1_Missense_Mutation_p.L954F|ACAN_ENST00000561243.1_Missense_Mutation_p.L954F|ACAN_ENST00000352105.7_Missense_Mutation_p.L954F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	954					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTTGGGGATCTCAGTGGACT	0.557000													75	108					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417474	150417474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150417474G>A	ENST00000307194.5	+	3	522	c.382G>A	c.(382-384)Gac>Aac	p.D128N		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACCGCCCAGGACCAGCAGGC	0.647000													7	53					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9488924	9488924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9488924C>T	ENST00000402466.1	+	15	2189	c.1421C>T	c.(1420-1422)tCa>tTa	p.S474L	SETD5_ENST00000402198.1_Missense_Mutation_p.S572L|SETD5_ENST00000407969.1_Missense_Mutation_p.S591L|SETD5_ENST00000302463.6_Missense_Mutation_p.S474L|SETD5_ENST00000406341.1_Missense_Mutation_p.S572L			Q9C0A6	SETD5_HUMAN	SET domain containing 5	572										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AACTCTGTTTCAAATGTTACC	0.458000													61	139					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839623	15839623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15839623C>T	ENST00000305899.3	+	1	790	c.770C>T	c.(769-771)tCt>tTt	p.S257F		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GGCTTTGCCTCTGTCATCTAC	0.562000													29	111					0	0	1	0	0
CXCR2P1	3580	broad.mit.edu	37	2	218925373	218925373	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:218925373G>A	ENST00000439871.1	-	0	1007					NR_002712.1																						AGGAAAATGAGGACAACAGCA	0.547000													8	75					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	549866	549866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:549866C>T	ENST00000239830.4	+	11	1304	c.1125C>T	c.(1123-1125)gcC>gcT	p.A375A	CCDC77_ENST00000422000.1_Silent_p.A343A|CCDC77_ENST00000540180.1_Silent_p.A343A|CCDC77_ENST00000412006.2_Silent_p.A343A	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	375						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			AAGAACTTGCCCGAATTCGTG	0.433000													20	67					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687851	68687851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:68687851C>T	ENST00000361320.4	+	2	1755	c.1177C>T	c.(1177-1179)Ccc>Tcc	p.P393S	CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	393						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TGAGAGCAAACCCCCTTTGCC	0.597000													23	74					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36054167	36054167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36054167C>T	ENST00000262623.3	-	3	188	c.160G>A	c.(160-162)Gac>Aac	p.D54N		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	54					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AGCTGGTGGTCGTTCTGTGTG	0.652000													69	188					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95480886	95480886	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95480886C>T	ENST00000432432.2	-	0	2474					NR_040113.1																						TGATCACATTCATTCATTAGC	0.323000													40	116					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57670611	57670611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57670611G>A	ENST00000554048.2	-	3	215	c.216C>T	c.(214-216)ttC>ttT	p.F72F		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	72						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		GTCTTTTCTGGAATCCGTGCC	0.418000													29	95					0	0	1	0	0
KRT84	3890	broad.mit.edu	37	12	52775247	52775247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52775247G>A	ENST00000257951.3	-	5	1041	c.975C>T	c.(973-975)agC>agT	p.S325S	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	325	Linker 12.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCAGGTCACGGCTGTTGTCCA	0.557000													85	162					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33703677	33703677	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33703677C>T	ENST00000336934.5	-	5	1253	c.1137G>A	c.(1135-1137)ggG>ggA	p.G379G	STARD13_ENST00000255486.4_Silent_p.G371G|STARD13_ENST00000399365.3_Silent_p.G261G	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	379					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GGCTTTGGTCCCCTGCATCCG	0.547000													22	104					0	0	1	0	0
USP38	84640	broad.mit.edu	37	4	144133528	144133528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:144133528C>T	ENST00000307017.4	+	8	2061	c.1555C>T	c.(1555-1557)Ccc>Tcc	p.P519S	USP38_ENST00000510377.1_Missense_Mutation_p.P519S	NM_032557.5	NP_115946.2	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	519					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					ATGGTTTACTCCCAGATCACA	0.378000													23	93					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46244896	46244896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46244896G>A	ENST00000296140.3	-	2	1034	c.909C>T	c.(907-909)ttC>ttT	p.F303F	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	303					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		TCTCACCAACGAAGGCGTAGA	0.582000													17	30					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21727167	21727167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21727167G>A	ENST00000261195.2	-	4	843	c.589C>T	c.(589-591)Cct>Tct	p.P197S		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	197					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GTGGCAATAGGAAGTTTCCTG	0.418000													14	84					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155451384	155451384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155451384G>A	ENST00000368346.3	-	3	1916	c.1277C>T	c.(1276-1278)gCc>gTc	p.A426V	ASH1L_ENST00000548830.1_3'UTR|ASH1L_ENST00000392403.3_Missense_Mutation_p.A426V			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	426					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CAGTGCTTCGGCTTTAAGGTT	0.418000													46	81					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31793040	31793040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31793040C>T	ENST00000396193.1	-	19	2861	c.2268G>A	c.(2266-2268)atG>atA	p.M756I	PDE1C_ENST00000396191.1_Missense_Mutation_p.M696I|PDE1C_ENST00000321453.7_Missense_Mutation_p.M696I	NM_001191058.1	NP_001177987.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	696					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GAATCTTTTTCATTTTGATCC	0.468000													102	284					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187333	123187333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123187333C>T	ENST00000328880.5	-	1	557	c.498G>A	c.(496-498)aaG>aaA	p.K166K	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	166					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	GGATCGGCATCTTCTTCTTCA	0.537000													23	66					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158746540	158746540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158746540C>T	ENST00000339258.1	-	1	885	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					TTAATGATTTCCTTGTTACGA	0.408000													42	174					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56574793	56574793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56574793G>A	ENST00000394023.3	-	11	1154	c.1049C>T	c.(1048-1050)cCc>cTc	p.P350L	RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000550164.1_Missense_Mutation_p.P350L|SMARCC2_ENST00000347471.4_Missense_Mutation_p.P350L|SMARCC2_ENST00000267064.4_Missense_Mutation_p.P350L	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	350					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TTCTACATTGGGGACTGGTGA	0.557000													31	181					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20915772	20915772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20915772C>T	ENST00000375071.3	+	1	332	c.150C>T	c.(148-150)ttC>ttT	p.F50F	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	50					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	GGAGAATCTTCAAAGGTAAAG	0.622000													12	36					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90503081	90503081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90503081G>A	ENST00000325643.5	+	4	3745	c.3679G>A	c.(3679-3681)Gcc>Acc	p.A1227T		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GACCTCTGAAGCCAGTGGGAG	0.597000													4	26					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141619083	141619083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141619083G>A	ENST00000548136.1	+	1	467	c.408G>A	c.(406-408)atG>atA	p.M136I	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					ACATCATTATGAACAGACACA	0.458000													77	157					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118147569	118147569	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:118147569G>A	ENST00000456015.2	+	1	3	c.3G>A	c.(1-3)atG>atA	p.M1I	SLC30A8_ENST00000427715.2_5'UTR|SLC30A8_ENST00000521243.1_Intron|SLC30A8_ENST00000521035.1_3'UTR|SLC30A8_ENST00000519688.1_5'UTR	NM_173851.2	NP_776250.2	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	1					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity	p.M1I(1)		breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TGGCCGTCATGGAGTTTCTTG	0.413000													46	135					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272747	81272747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81272747C>T	ENST00000520547.2	+	1	391	c.342C>T	c.(340-342)ctC>ctT	p.L114L		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	114					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			ACCTTCGTCTCCCTGAGGGAG	0.547000													25	137					0	0	1	0	0
OR13C9	286362	broad.mit.edu	37	9	107380046	107380046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107380046C>T	ENST00000259362.1	-	1	439	c.440G>A	c.(439-441)gGg>gAg	p.G147E		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						AAACCAGGACCCAACAGCCAT	0.453000													51	91					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35550838	35550838	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35550838C>T	ENST00000262626.2	+	6	1176	c.351C>T	c.(349-351)ttC>ttT	p.F117F	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000600675.1_3'UTR|HPN_ENST00000597419.1_Intron|HPN_ENST00000392226.1_Silent_p.F117F	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	117	SRCR.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	CGTCGGGCTTCTTCTGTGTGG	0.697000													6	13					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263334	39263334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39263334C>T	ENST00000280481.7	+	1	2069	c.1853C>T	c.(1852-1854)cCc>cTc	p.P618L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	618					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ACTCACCCTCCCCATGAGAAG	0.522000													5	78					0	0	1	0	0
NMUR1	10316	broad.mit.edu	37	2	232393203	232393203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:232393203G>A	ENST00000305141.4	-	2	662	c.529C>T	c.(529-531)Cat>Tat	p.H177Y		NM_006056.4	NP_006047.3	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	177					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(12)|pancreas(1)|skin(1)	24		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CGGCGCACATGGGCCCGCGTC	0.682000													21	45					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80044354	80044354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80044354G>A	ENST00000306749.2	-	22	3726	c.3508C>T	c.(3508-3510)Ccc>Tcc	p.P1170S		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1170					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGGTCCCGGGGGATCTGGGCC	0.687000													12	31					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37462938	37462938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37462938C>T	ENST00000381792.2	-	18	2384	c.2244G>A	c.(2242-2244)gaG>gaA	p.E748E	TMPRSS6_ENST00000406725.1_Silent_p.E726E|TMPRSS6_ENST00000406856.1_Silent_p.E748E|TMPRSS6_ENST00000346753.3_Silent_p.E735E			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	735	Peptidase S1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						AGCGATAGACCTCGCTGCACA	0.607000													16	29					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114275491	114275491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114275491C>T	ENST00000357077.4	+	38	5770	c.5717C>T	c.(5716-5718)cCt>cTt	p.P1906L	ANK2_ENST00000264366.6_Missense_Mutation_p.P1873L|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1873	Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCTGTTTCGCCTTCAGGCAAA	0.488000													22	67					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176998797	176998797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176998797G>A	ENST00000367654.2	-	5	1106	c.1093C>T	c.(1093-1095)Cct>Tct	p.P365S	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.P365S|ASTN1_ENST00000367657.3_Missense_Mutation_p.P365S|ASTN1_ENST00000361833.2_Missense_Mutation_p.P365S			O14525	ASTN1_HUMAN	astrotactin 1	365					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CTCCTTGAAGGATCCGTGTAA	0.552000													7	34					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640348	179640348	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179640348G>A	ENST00000589042.1	-	28	6467	c.6243C>T	c.(6241-6243)ttC>ttT	p.F2081F	TTN_ENST00000342992.6_Silent_p.F2081F|TTN_ENST00000360870.5_Silent_p.F2081F|TTN_ENST00000460472.2_Silent_p.F2035F|TTN_ENST00000342175.6_Silent_p.F2035F|TTN_ENST00000359218.5_Silent_p.F2035F|TTN_ENST00000591111.1_Silent_p.F2081F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1844	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.F2035L(3)|p.F2081L(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGATTCTTTCGAAGATTTTTG	0.453000													29	73					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28537606	28537606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:28537606G>A	ENST00000401766.2	-	10	1888	c.1376C>T	c.(1375-1377)gCc>gTc	p.A459V	SLC6A4_ENST00000261707.3_Missense_Mutation_p.A459V			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	459					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CCGGCGCTTGGCCCAGACGTG	0.592000													8	72					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711301	20711301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20711301G>A	ENST00000315409.2	+	1	404	c.351G>A	c.(349-351)ctG>ctA	p.L117L		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		TCTTTTCACTGGGAACAACTG	0.463000													21	95					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100055656	100055656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:100055656G>A	ENST00000258428.3	-	6	848	c.620C>T	c.(619-621)tCt>tTt	p.S207F	REV1_ENST00000393445.3_Missense_Mutation_p.S207F|REV1_ENST00000465835.1_5'UTR	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	207					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCTTCCCGGAGAGGTCTGCTC	0.418000								Direct reversal of damage					11	49					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36348040	36348040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36348040C>T	ENST00000360202.5	+	1	217	c.19C>T	c.(19-21)Ccc>Tcc	p.P7S	KIRREL2_ENST00000347900.6_Missense_Mutation_p.P7S|KIRREL2_ENST00000592409.1_Missense_Mutation_p.P7S|KIRREL2_ENST00000586102.2_Missense_Mutation_p.P7S|KIRREL2_ENST00000262625.7_Missense_Mutation_p.P7S|NPHS1_ENST00000591817.1_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	7					cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GATGCGGGTCCCCGCCCTCCT	0.632000													20	47					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1268686	1268686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1268686G>A	ENST00000447027.1	+	31	10643	c.10585G>A	c.(10585-10587)Ggg>Agg	p.G3529R	MUC5B_ENST00000529681.1_Missense_Mutation_p.G3526R|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3526	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCTTCTCCAGGGACGACCAC	0.687000													25	101					0	0	1	0	0
MYOZ1	58529	broad.mit.edu	37	10	75399765	75399765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75399765G>A	ENST00000359322.4	-	2	375	c.11C>T	c.(10-12)tCa>tTa	p.S4L		NM_021245.3	NP_067068.1	Q9NP98	MYOZ1_HUMAN	myozenin 1	4					myofibril assembly	nucleus|pseudopodium	FATZ binding			central_nervous_system(1)|large_intestine(5)|lung(2)|ovary(2)|skin(2)	12	Prostate(51;0.0112)					CGGGGTTCCTGAGAGCGGCAT	0.542000													14	98					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110301041	110301041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110301041G>A	ENST00000369805.3	-	8	846	c.617C>T	c.(616-618)tCc>tTc	p.S206F	RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361852.4_Missense_Mutation_p.S205F|EPS8L3_ENST00000361965.4_Missense_Mutation_p.S205F|EPS8L3_ENST00000494151.1_5'UTR	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	205	Pro-rich.					cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GGGCCTTGGGGATGGTGGGAG	0.597000													15	185					0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41033272	41033272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41033272C>T	ENST00000380620.3	+	5	1378	c.786C>T	c.(784-786)tcC>tcT	p.S262S	B3GALT5_ENST00000398714.2_Silent_p.S262S|B3GALT5_ENST00000380618.1_Silent_p.S262S|AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000343118.4_Silent_p.S262S			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	262					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				AGCTCCACTCCCAGCCGACCT	0.532000													58	96					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17657536	17657536	+	Silent	SNP	C	C	T	rs77182432	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17657536C>T	ENST00000375448.4	+	2	191	c.165C>T	c.(163-165)ggC>ggT	p.G55G	PADI4_ENST00000375453.1_Silent_p.G55G|AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	55			G -> S (in dbSNP:rs11203366).		chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	TTGCCCACGGCCCTCCAGCCA	0.602000													23	45					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183710312	183710312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183710312G>A	ENST00000511685.1	+	25	5494	c.5371G>A	c.(5371-5373)Gac>Aac	p.D1791N	TENM3_ENST00000406950.2_Missense_Mutation_p.D1791N					teneurin transmembrane protein 3																		GATCTATGACGACCACCGTAA	0.453000													5	16					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37975632	37975632	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37975632C>T	ENST00000330173.1	+	5	1637	c.1108C>T	c.(1108-1110)Cgt>Tgt	p.R370C	ZNF570_ENST00000586475.1_Missense_Mutation_p.R426C|ZNF570_ENST00000388801.3_Missense_Mutation_p.R167C	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTTAGCCTTCGTGCATACCT	0.428000													8	96					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430764	135430764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135430764G>A	ENST00000394143.1	+	6	5190	c.4899G>A	c.(4897-4899)atG>atA	p.M1633I	GPR112_ENST00000370652.1_Missense_Mutation_p.M1633I|GPR112_ENST00000287534.4_Missense_Mutation_p.M1570I|GPR112_ENST00000394141.1_Missense_Mutation_p.M1428I|GPR112_ENST00000412101.1_Missense_Mutation_p.M1428I	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1633					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTACAGAAATGATAGAGGCAC	0.448000													66	53					0	0	1	0	0
FAM19A4	151647	broad.mit.edu	37	3	68802034	68802034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:68802034G>A	ENST00000295569.7	-	4	758	c.266C>T	c.(265-267)gCt>gTt	p.A89V		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	89						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		AGAAGGTTGAGCCCGAGTTGT	0.517000													28	85					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33565900	33565900	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33565900G>A	ENST00000262873.7	+	3	309		c.e3+1			NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta							membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CCATGGGACGGTAAGTGGAGA	0.602000													15	52					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43926790	43926790	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43926790G>A	ENST00000282406.4	+	8	803	c.693G>A	c.(691-693)atG>atA	p.M231I		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	231						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTCTAGAAATGGAAATTCCAG	0.368000													23	54					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95518576	95518576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95518576C>T	ENST00000371418.4	+	2	535	c.275C>T	c.(274-276)tCg>tTg	p.S92L	LGI1_ENST00000371413.3_Missense_Mutation_p.S92L|LGI1_ENST00000478763.1_3'UTR|LGI1_ENST00000542308.1_Missense_Mutation_p.S92L	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	92					axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				TTCACGCCATCGCTGCAGCTC	0.313000													30	52					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3675457	3675457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3675457C>T	ENST00000344754.4	-	11	2796	c.2797G>A	c.(2797-2799)Gat>Aat	p.D933N	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.D933N	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	933	Ig-like C2-type 9.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGCTGGCCATCCCGATACCAA	0.617000													26	56					0	0	1	0	0
LCN9	392399	broad.mit.edu	37	9	138555222	138555222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138555222G>A	ENST00000277526.3	+	1	55	c.55G>A	c.(55-57)Gat>Aat	p.D19N	LCN9_ENST00000430290.2_3'UTR	NM_001001676.1	NP_001001676.1	Q8WX39	LCN9_HUMAN	lipocalin 9	19						extracellular region	pheromone binding|transporter activity			kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	6		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		CCAGGAGTTCGATCCCCACAC	0.627000													14	56					0	0	1	0	0
BDH1	622	broad.mit.edu	37	3	197239115	197239115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:197239115G>A	ENST00000392379.1	-	8	1084	c.683C>T	c.(682-684)cCc>cTc	p.P228L	BDH1_ENST00000392378.2_Missense_Mutation_p.P228L|BDH1_ENST00000358186.2_Missense_Mutation_p.P228L|BDH1_ENST00000441275.1_Missense_Mutation_p.P141L	NM_203314.2	NP_976059.1	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	228					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	CACGCCCAGGGGGTACATCTC	0.622000													19	25					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125109512	125109512	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125109512G>A	ENST00000522917.1	+	36	4902	c.4695_splice	c.e36-1	p.G1566_splice	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Splice_Site_p.G1566_splice	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1566						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTTAACAAGGGCCGCCTGCA	0.453000													10	113					0	0	1	0	0
LCP2	3937	broad.mit.edu	37	5	169720347	169720347	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169720347C>T	ENST00000046794.5	-	2	723	c.108G>A	c.(106-108)gtG>gtA	p.V36V		NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	36	SAM.				immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		GGTACTTCTTCACTGCCTTCT	0.522000													10	15					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141619380	141619380	+	Silent	SNP	G	G	A	rs143629932		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141619380G>A	ENST00000548136.1	+	1	764	c.705G>A	c.(703-705)agG>agA	p.R235R	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R235R(1)		NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					CTGGCCGGAGGAAATCCTTCT	0.502000													45	105					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111215776	111215776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111215776G>A	ENST00000369769.2	-	1	1879	c.1656C>T	c.(1654-1656)tcC>tcT	p.S552S		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	552						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGGTGGCAGTGGAATTGCCCG	0.463000													37	128					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107923951	107923951	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107923951C>T	ENST00000328300.6	+	45	4229	c.3985C>T	c.(3985-3987)Cct>Tct	p.P1329S	COL4A5_ENST00000361603.2_Missense_Mutation_p.P1323S	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1323	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GAAAGGAGATCCTGGTCTCCC	0.428000									Alport syndrome with Diffuse Leiomyomatosis				23	13					0	0	1	0	0
PATL1	219988	broad.mit.edu	37	11	59423479	59423479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59423479G>A	ENST00000300146.9	-	7	847	c.763C>T	c.(763-765)Cct>Tct	p.P255S		NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	255	Pro-rich.|Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						AGAACAGGAGGAACACTAGGA	0.428000													5	13					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003641	34003641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34003641G>A	ENST00000374181.3	-	8	2415	c.2246C>T	c.(2245-2247)tCg>tTg	p.S749L	GRM4_ENST00000535756.1_Missense_Mutation_p.S616L|GRM4_ENST00000374177.3_Missense_Mutation_p.S633L|GRM4_ENST00000538487.1_Missense_Mutation_p.S749L|GRM4_ENST00000545715.1_Missense_Mutation_p.S441L|GRM4_ENST00000455714.2_Missense_Mutation_p.S609L|GRM4_ENST00000544773.1_Missense_Mutation_p.S580L	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	749					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CGACAGGTCCGAGATGTCACA	0.617000													12	66					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46122066	46122066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46122066G>A	ENST00000374366.3	-	8	1448	c.983C>T	c.(982-984)gCt>gTt	p.A328V	ZFAND4_ENST00000374370.1_5'UTR|ZFAND4_ENST00000374371.2_Intron|ZFAND4_ENST00000344646.5_Missense_Mutation_p.A402V			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	402							zinc ion binding										TGCAAATGAAGCCAGTGAGCC	0.433000													45	103					0	0	1	0	0
SLC22A17	51310	broad.mit.edu	37	14	23817773	23817773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23817773C>T	ENST00000354772.3	-	5	1137	c.634G>A	c.(634-636)Gat>Aat	p.D212N	SLC22A17_ENST00000474057.1_Intron|SLC22A17_ENST00000397267.1_Missense_Mutation_p.D212N|SLC22A17_ENST00000206544.8_Missense_Mutation_p.D212N|SLC22A17_ENST00000397260.3_Missense_Mutation_p.D101N	NM_016609.3	NP_057693.3	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17	212					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		AATCGCCAATCCTTAGAGACA	0.587000													43	112					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150647386	150647386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150647386C>T	ENST00000392968.2	-	7	3100	c.1980G>A	c.(1978-1980)atG>atA	p.M660I	KCNH2_ENST00000330883.4_Missense_Mutation_p.M416I|KCNH2_ENST00000430723.3_Missense_Mutation_p.M756I|KCNH2_ENST00000262186.5_Missense_Mutation_p.M756I			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	756					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TCTTGAACTTCATGGCCAGGG	0.637000													8	85					0	0	1	0	0
ZNF200	7752	broad.mit.edu	37	16	3274129	3274129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3274129G>A	ENST00000431561.3	-	5	1563	c.951C>T	c.(949-951)ttC>ttT	p.F317F	ZNF200_ENST00000396868.3_Silent_p.F316F|AJ003147.9_ENST00000576468.1_RNA|ZNF200_ENST00000396871.4_Silent_p.F316F|ZNF200_ENST00000396870.4_Silent_p.F316F|ZNF200_ENST00000414144.2_Silent_p.F317F|ZNF200_ENST00000575948.1_Silent_p.F316F	NM_001145447.1|NM_003454.3	NP_001138919.1|NP_003445.2	P98182	ZN200_HUMAN	zinc finger protein 200	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	17						AATTCTGACGGAAGTTTTTTC	0.393000													118	81					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34064165	34064165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34064165G>A	ENST00000389232.4	+	63	8931	c.8861G>A	c.(8860-8862)cGa>cAa	p.R2954Q	RYR3_ENST00000415757.3_Missense_Mutation_p.R2954Q	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2954					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTGGGTTACGAGCATTCTTT	0.443000													7	20					0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048030	6048030	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6048030C>T	ENST00000316650.5	-	1	941	c.905G>A	c.(904-906)cGg>cAg	p.R302Q		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTTTGGTCCGAACCCCATA	0.448000													8	82					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62887153	62887153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:62887153G>A	ENST00000281156.4	-	2	434	c.156C>T	c.(154-156)gtC>gtT	p.V52V		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	52					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TGTTGCTGATGACATCAAGAT	0.328000													14	32					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10464881	10464881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10464881C>T	ENST00000382483.3	-	4	6950	c.6727G>A	c.(6727-6729)Gga>Aga	p.G2243R		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2243					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TGAGTTTCTCCTTCTGACTCT	0.602000													45	146					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146673593	146673593	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:146673593A>T	ENST00000392299.2	+	5	1864	c.1394A>T	c.(1393-1395)gAg>gTg	p.E465V	GRM1_ENST00000507907.1_Missense_Mutation_p.E465V|GRM1_ENST00000282753.1_Missense_Mutation_p.E465V|GRM1_ENST00000355289.4_Missense_Mutation_p.E465V|GRM1_ENST00000361719.2_Missense_Mutation_p.E465V|GRM1_ENST00000492807.2_Missense_Mutation_p.E465V			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	465					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GTATCTGGAGAGGAGGTGTGG	0.522000													45	126					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62398592	62398592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62398592G>A	ENST00000346178.4	-	11	1141	c.1126C>T	c.(1126-1128)Cgc>Tgc	p.R376C	GANAB_ENST00000356638.3_Missense_Mutation_p.R354C|GANAB_ENST00000540933.1_Missense_Mutation_p.R257C|GANAB_ENST00000534779.1_Missense_Mutation_p.R262C	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	354					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GACATCCAGCGAACATCTGTC	0.537000													78	285					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242383356	242383356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:242383356G>A	ENST00000442594.2	-	6	902	c.393C>T	c.(391-393)ttC>ttT	p.F131F	PLD5_ENST00000536534.1_Silent_p.F223F|PLD5_ENST00000427495.1_Silent_p.F161F	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	223						integral to membrane	catalytic activity	p.F223L(1)|p.F131L(1)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CCACGATCCAGAAGGAGGACT	0.522000													8	62					0	0	1	0	0
HOXC10	3226	broad.mit.edu	37	12	54379110	54379110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54379110G>A	ENST00000303460.4	+	1	141	c.67G>A	c.(67-69)Gag>Aag	p.E23K	HOXC-AS3_ENST00000514702.1_RNA	NM_017409.3	NP_059105.2	Q9NYD6	HXC10_HUMAN	homeobox C10	23					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(14)|pancreas(1)	20						CGGCGGAGGAGAGCGCTATAG	0.587000													46	100					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058360	9058360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9058360C>T	ENST00000397910.4	-	3	29289	c.29086G>A	c.(29086-29088)Gga>Aga	p.G9696R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9698	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGAAAGTCCTTGAGACATA	0.493000													17	54					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13769225	13769225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13769225C>T	ENST00000265104.4	-	58	9845	c.9741G>A	c.(9739-9741)atG>atA	p.M3247I	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3247	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCTGTGCTTTCATTGTCACTT	0.418000									Kartagener syndrome				93	222					0	0	1	0	0
MAPK4	5596	broad.mit.edu	37	18	48255634	48255634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:48255634G>A	ENST00000400384.2	+	6	2210	c.1174G>A	c.(1174-1176)Gac>Aac	p.D392N	MAPK4_ENST00000540640.1_Missense_Mutation_p.D181N|MAPK4_ENST00000592595.1_3'UTR	NM_002747.3	NP_002738.2	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	392					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(3)|upper_aerodigestive_tract(1)	8		Colorectal(6;0.0297)		Colorectal(21;0.156)		ACTGGCTGAGGACGTGCAGGT	0.701000													8	26					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32198639	32198639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32198639G>A	ENST00000373658.3	-	26	3899	c.3558C>T	c.(3556-3558)ctC>ctT	p.L1186L	BAI2_ENST00000398556.3_Silent_p.L1101L|BAI2_ENST00000373655.2_Silent_p.L1186L|BAI2_ENST00000257070.4_Silent_p.L1153L|BAI2_ENST00000465256.1_5'UTR|BAI2_ENST00000398538.1_Silent_p.L1174L|BAI2_ENST00000527361.1_Silent_p.L1153L|BAI2_ENST00000398542.1_Silent_p.L1086L|BAI2_ENST00000398547.1_Silent_p.L1119L|BAI2_ENST00000440175.2_Silent_p.L795L	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	1186					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		AGACAGCAAAGAGGGCCTGGA	0.647000													5	6					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445109	49445109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49445109G>A	ENST00000301067.7	-	10	2356	c.2357C>T	c.(2356-2358)cCa>cTa	p.P786L		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGACAAGTGTGGCTCCTCAGG	0.657000													17	32					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36370284	36370284	+	Missense_Mutation	SNP	G	G	A	rs147200750		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36370284G>A	ENST00000221891.4	+	17	2089	c.1897G>A	c.(1897-1899)Gaa>Aaa	p.E633K	APLP1_ENST00000586861.1_Missense_Mutation_p.E626K|APLP1_ENST00000537454.2_Missense_Mutation_p.E593K	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	632					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCAGCTCCGCGAACTGCAGCG	0.672000													30	96					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215807923	215807923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215807923G>A	ENST00000366943.2	-	70	15561	c.15175C>T	c.(15175-15177)Ctg>Ttg	p.L5059L	USH2A_ENST00000307340.3_Silent_p.L5059L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5059					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATCAGGGACAGAAAAATGGCC	0.438000										HNSCC(13;0.011)			7	113					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66258726	66258726	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66258726C>T	ENST00000532677.1	+	7	1128	c.727C>T	c.(727-729)Cct>Tct	p.P243S	DPP3_ENST00000541961.1_Missense_Mutation_p.P224S|DPP3_ENST00000360510.2_Missense_Mutation_p.P224S|DPP3_ENST00000531863.1_Missense_Mutation_p.P244S|DPP3_ENST00000453114.1_Missense_Mutation_p.P224S|DPP3_ENST00000530165.1_Missense_Mutation_p.P194S	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	224					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TTCCCCAGAGCCTTCCCTGGA	0.552000											OREG0021109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	161					0	0	1	0	0
APOL3	80833	broad.mit.edu	37	22	36538042	36538042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36538042C>T	ENST00000397293.2	-	4	549	c.202G>A	c.(202-204)Gaa>Aaa	p.E68K	APOL3_ENST00000487423.1_5'UTR|APOL3_ENST00000349314.2_Missense_Mutation_p.E139K|APOL3_ENST00000424878.2_5'UTR|APOL3_ENST00000361710.2_5'UTR|APOL3_ENST00000397287.2_5'UTR			O95236	APOL3_HUMAN	apolipoprotein L, 3	139					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity			endometrium(2)|large_intestine(1)|lung(1)|stomach(1)	5						TGCACATATTCGTCCTCAATA	0.438000													30	62					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64136112	64136112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:64136112G>A	ENST00000395254.3	+	2	440	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	ZNF365_ENST00000410046.3_Missense_Mutation_p.E54K|ZNF365_ENST00000395255.3_Missense_Mutation_p.E54K|ZNF365_ENST00000466727.1_Intron	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					TCACAGCTACGAAGAAAGAAC	0.498000													8	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179443794	179443794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179443794C>T	ENST00000589042.1	-	320	68187	c.67963G>A	c.(67963-67965)Gaa>Aaa	p.E22655K	TTN_ENST00000342992.6_Missense_Mutation_p.E20087K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E13590K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E13782K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E13715K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|RP11-171I2.2_ENST00000603521.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E21014K|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21014	Fibronectin type-III 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTGACTTCATCAAATTTG	0.453000													25	36					0	0	1	0	0
SLC16A13	201232	broad.mit.edu	37	17	6940077	6940077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6940077C>T	ENST00000308027.6	+	2	539	c.231C>T	c.(229-231)ttC>ttT	p.F77F		NM_201566.2	NP_963860.1	Q7RTY0	MOT13_HUMAN	solute carrier family 16, member 13	77						integral to membrane|plasma membrane	symporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						GCACGAAGTTCGGGCCCAGGC	0.632000													15	112					0	0	1	0	0
TBC1D13	54662	broad.mit.edu	37	9	131559401	131559401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131559401C>T	ENST00000372648.5	+	7	601	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	TBC1D13_ENST00000466056.1_3'UTR|TBC1D13_ENST00000539497.1_5'UTR|TBC1D13_ENST00000223865.8_Missense_Mutation_p.P151S	NM_018201.3	NP_060671.3	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	151	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	6						CATCCTGGACCCCCAGAATGA	0.517000													29	108					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120802039	120802039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:120802039G>A	ENST00000369144.3	-	19	3120	c.2993C>T	c.(2992-2994)cCc>cTc	p.P998L	EIF3A_ENST00000541549.1_Missense_Mutation_p.P964L|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	998	25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].|Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AATTCGTCTGGGAGGCCTGTC	0.572000													19	208					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121485641	121485641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121485641G>A	ENST00000260197.7	+	41	5610	c.5481G>A	c.(5479-5481)ggG>ggA	p.G1827G	SORL1_ENST00000534286.1_Silent_p.G737G|SORL1_ENST00000525532.1_Silent_p.G771G|SORL1_ENST00000532694.1_Silent_p.G673G|SORL1_ENST00000527934.1_Silent_p.G442G	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1827	Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CTGACTTGGGGGATAGCCCTC	0.512000													47	107					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50266392	50266392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50266392C>T	ENST00000246801.3	-	1	195	c.113G>A	c.(112-114)aGg>aAg	p.R38K		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	38							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GCTGGTCACCCTCCGGGGAGC	0.622000													46	101					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158500435	158500435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:158500435C>T	ENST00000313708.6	-	6	805	c.523G>A	c.(523-525)Gag>Aag	p.E175K	EBF1_ENST00000517373.1_Missense_Mutation_p.E175K|EBF1_ENST00000380654.4_Intron|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	175					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAGGGAGTCTCATTTCGGTTG	0.418000			T	HMGA2	lipoma								60	115					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55534823	55534823	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55534823A>T	ENST00000220676.1	+	3	910	c.762A>T	c.(760-762)ggA>ggT	p.G254G		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	254					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACCCCAAGGGAAATGCAAAGT	0.413000													23	63					0	0	1	0	0
OR2H2	7932	broad.mit.edu	37	6	29555752	29555752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29555752C>T	ENST00000383640.2	+	1	70	c.31C>T	c.(31-33)Ctc>Ttc	p.L11F	GABBR1_ENST00000355973.3_Intron	NM_007160.3	NP_009091.3	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H, member 2	11					defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	14						ACCGGGCTTCCTCCTTCTGGG	0.512000													58	150					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111060399	111060399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111060399C>T	ENST00000369771.2	-	1	1398	c.1011G>A	c.(1009-1011)ctG>ctA	p.L337L		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	337						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TCAGGATGGCCAGGGACATGT	0.547000													43	142					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106918652	106918652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106918652C>T	ENST00000369701.3	+	11	1859	c.1632C>T	c.(1630-1632)ccC>ccT	p.P544P		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	544						integral to membrane	neuropeptide receptor activity	p.P544P(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CATTTTAGCCCTTCTGTTCCT	0.478000													21	72					0	0	1	0	0
PRKCH	5583	broad.mit.edu	37	14	61924237	61924237	+	Missense_Mutation	SNP	G	G	A	rs61740172	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:61924237G>A	ENST00000332981.5	+	9	1503	c.1118G>A	c.(1117-1119)aGa>aAa	p.R373K	PRKCH_ENST00000555082.1_Missense_Mutation_p.R212K	NM_006255.3	NP_006246.2	P24723	KPCL_HUMAN	protein kinase C, eta	373	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		ATGCTTGCAAGAGTAAAAGAA	0.488000													15	193					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86814879	86814879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86814879G>A	ENST00000441037.2	+	14	1974	c.1879G>A	c.(1879-1881)Gag>Aag	p.E627K	AGBL1_ENST00000421325.2_Missense_Mutation_p.E627K|AGBL1_ENST00000389298.3_Missense_Mutation_p.E358K	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	627					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TTCTGTGAAGGAGGCTCTTCT	0.443000													22	126					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345675	92345675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:92345675C>T	ENST00000377067.3	+	3	932	c.560C>T	c.(559-561)tCc>tTc	p.S187F		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	187						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ACTGACAGTTCCCTGGAATAC	0.473000													85	114					0	0	1	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698666	111698666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:111698666C>T	ENST00000340433.2	+	1	940	c.710C>T	c.(709-711)tCc>tTc	p.S237F		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	237							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						TTGTTGGCTTCCTTGATCCAA	0.532000													94	78					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48134543	48134543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48134543C>T	ENST00000405493.2	-	21	2196	c.1987G>A	c.(1987-1989)Gag>Aag	p.E663K	RAPGEF3_ENST00000549151.1_Missense_Mutation_p.E663K|RAPGEF3_ENST00000548919.1_Missense_Mutation_p.E614K|RAPGEF3_ENST00000389212.3_Missense_Mutation_p.E705K|RAPGEF3_ENST00000171000.4_Missense_Mutation_p.E663K|RP1-197B17.3_ENST00000547799.1_lincRNA|RAPGEF3_ENST00000449771.2_Missense_Mutation_p.E705K	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	663					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		ATGAAGCGCTCCAGGTTGGCG	0.657000													18	57					0	0	1	0	0
MPZL2	10205	broad.mit.edu	37	11	118134847	118134847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118134847G>A	ENST00000278937.2	-	1	150	c.22C>T	c.(22-24)Cgt>Tgt	p.R8C	MPZL2_ENST00000438295.2_Missense_Mutation_p.R8C|MPZL2_ENST00000525647.1_5'UTR	NM_005797.3	NP_005788.1	O60487	MPZL2_HUMAN	myelin protein zero-like 2	8					anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|skin(1)	11	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		AGCACCGCACGAGTAGAGCTC	0.577000													6	71					0	0	1	0	0
NOX4	50507	broad.mit.edu	37	11	89166025	89166025	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:89166025C>T	ENST00000535633.1	-	7	714		c.e7-1		NOX4_ENST00000542487.1_Splice_Site|NOX4_ENST00000263317.4_Splice_Site|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000525196.1_Splice_Site|NOX4_ENST00000343727.5_Splice_Site|NOX4_ENST00000527626.1_Splice_Site|NOX4_ENST00000534731.1_Splice_Site|NOX4_ENST00000413594.2_Splice_Site|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000528341.1_Splice_Site|NOX4_ENST00000424319.1_Splice_Site|NOX4_ENST00000527956.1_Splice_Site|NOX4_ENST00000532825.1_Splice_Site	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AGGCCAGGAACTATAAAAATG	0.353000													7	36					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891236	18891236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18891236G>A	ENST00000317658.3	+	1	192	c.34G>A	c.(34-36)Gaa>Aaa	p.E12K		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	12					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				GAAGGACAAGGAAAGAGTAAT	0.423000													8	91					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101892274	101892274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101892274C>T	ENST00000360264.3	+	24	4523	c.4503C>T	c.(4501-4503)cgC>cgT	p.R1501R	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000556210.1_Silent_p.R1332R|CUX1_ENST00000550008.2_Silent_p.R1434R|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292535.7_Silent_p.R1490R|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000546411.2_Silent_p.R1388R|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000549414.2_Silent_p.R1468R	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	1490					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCATCCACCGCCTGGAGAAGG	0.706000													5	14					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965258	88965258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:88965258G>A	ENST00000333190.4	+	4	3571	c.2962G>A	c.(2962-2964)Gag>Aag	p.E988K		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	988						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTATGCAAGTGAGAGCAGAAA	0.398000										HNSCC(36;0.09)			38	71					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182347137	182347137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182347137G>A	ENST00000397033.2	+	8	1321	c.891G>A	c.(889-891)atG>atA	p.M297I		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	297					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TACATGAAATGAAAGGTAAAA	0.313000													26	74					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33507692	33507692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33507692G>A	ENST00000268876.5	+	18	2473	c.2376G>A	c.(2374-2376)aaG>aaA	p.K792K	UNC45B_ENST00000433649.1_Silent_p.K790K|UNC45B_ENST00000591048.1_Silent_p.K711K|UNC45B_ENST00000378449.1_Silent_p.K711K|UNC45B_ENST00000394570.2_Silent_p.K790K	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	792					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				TGCTCCACAAGGAGGTGAGGC	0.602000													11	23					0	0	1	0	0
GOLGA2P5	55592	broad.mit.edu	37	12	100550758	100550758	+	RNA	SNP	G	G	A	rs150859784	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100550758G>A	ENST00000397112.4	-	0	2063					NR_036632.1															large_intestine(1)|lung(3)	4						TCATCAGCAGGGTTCTGGGCA	0.632000													15	49					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043327	117043327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117043327G>A	ENST00000371876.1	-	4	3571	c.1150C>T	c.(1150-1152)Cac>Tac	p.H384Y	KLHL13_ENST00000371882.1_Missense_Mutation_p.H384Y|KLHL13_ENST00000539496.1_Missense_Mutation_p.H438Y|KLHL13_ENST00000262820.3_Missense_Mutation_p.H435Y|KLHL13_ENST00000540167.1_Missense_Mutation_p.H419Y|KLHL13_ENST00000545703.1_Missense_Mutation_p.H393Y|KLHL13_ENST00000541812.1_Missense_Mutation_p.H419Y|KLHL13_ENST00000371878.1_Missense_Mutation_p.H384Y|KLHL13_ENST00000469946.1_Missense_Mutation_p.H384Y			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	435					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GCACTTAGGTGGAAGAAGGTG	0.398000													18	16					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029801	150029801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150029801C>T	ENST00000394243.1	+	3	3070	c.2696C>T	c.(2695-2697)tCt>tTt	p.S899F	SYNPO_ENST00000519664.1_Missense_Mutation_p.S655F|SYNPO_ENST00000307662.4_Missense_Mutation_p.S655F|SYNPO_ENST00000522122.1_Missense_Mutation_p.S899F	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	899	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGGCGTGGTCTCCCCGAGCC	0.667000													37	124					0	0	1	0	0
TRAV2	28691	broad.mit.edu	37	14	22180969	22180969	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22180969G>A	ENST00000390424.2	+	0	251																											TTCTCAGCAGGGACGATACAA	0.502000													73	192					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55307294	55307294	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55307294G>A	ENST00000358193.3	+	10	1244	c.1190G>A	c.(1189-1191)aGg>aAg	p.R397K	C1orf177_ENST00000371273.3_Intron	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	397										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CTTAGAATCAGGCTGTTTTgt	0.428000													29	77					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39331857	39331857	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39331857C>T	ENST00000263408.4	-	5	631	c.536G>A	c.(535-537)gGa>gAa	p.G179E	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	179	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GTTACAGAGTCCATTGTAGAA	0.438000													48	147					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38858489	38858489	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38858489G>A	ENST00000359357.3	+	56	8138	c.7884G>A	c.(7882-7884)atG>atA	p.M2628I	DNAH8_ENST00000449981.2_Missense_Mutation_p.M2845I|DNAH8_ENST00000441566.1_Missense_Mutation_p.M2592I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TATGTGAGATGATTGTGAATT	0.358000													43	97					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179604982	179604982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179604982G>A	ENST00000444136.1	+	9	1730	c.1480G>A	c.(1480-1482)Gat>Aat	p.D494N	TDRD5_ENST00000367614.1_Missense_Mutation_p.D494N|TDRD5_ENST00000294848.8_Missense_Mutation_p.D494N	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	494					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CTATAGCAGGGATTCGTCAGA	0.408000													30	57					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50464087	50464087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:50464087C>T	ENST00000404971.1	-	19	4845	c.3506G>A	c.(3505-3507)aGc>aAc	p.S1169N	NRXN1_ENST00000402717.3_Missense_Mutation_p.S1121N|NRXN1_ENST00000401710.1_Missense_Mutation_p.S147N|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401669.2_Missense_Mutation_p.S1129N|NRXN1_ENST00000406859.3_Missense_Mutation_p.S1129N|NRXN1_ENST00000405472.3_Missense_Mutation_p.S1121N|NRXN1_ENST00000342183.5_Missense_Mutation_p.S94N|NRXN1_ENST00000406316.2_Missense_Mutation_p.S1129N	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1129	Laminin G-like 6.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.S94I(1)|p.S1170I(1)|p.S1129I(1)|p.S1169I(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACCACCTTTGCTAAAGATATA	0.413000													35	76					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686769	54686769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54686769C>T	ENST00000540264.2	-	2	1020	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	NFE2_ENST00000312156.4_Missense_Mutation_p.E171K|RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000553070.1_Missense_Mutation_p.E171K|NFE2_ENST00000435572.2_Missense_Mutation_p.E171K			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	171	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						TCTACATATTCGCTGCGCCGC	0.562000													16	104					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6833264	6833264	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6833264C>T	ENST00000304076.2	+	16	1672	c.1578C>T	c.(1576-1578)acC>acT	p.T526T	VAV1_ENST00000539284.1_Silent_p.T429T|VAV1_ENST00000602142.1_Silent_p.T526T|VAV1_ENST00000599806.1_Silent_p.T471T|VAV1_ENST00000596764.1_Silent_p.T494T	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	526					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						TTGAGGAGACCACATCCTGCA	0.498000													8	50					0	0	1	0	0
TMCO1	54499	broad.mit.edu	37	1	165697266	165697266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165697266G>A	ENST00000367881.5	-	7	989	c.714C>T	c.(712-714)ttC>ttT	p.F238F	TMCO1_ENST00000580248.1_Silent_p.F103F|TMCO1_ENST00000392129.6_Silent_p.F187F|TMCO1_ENST00000464650.1_Silent_p.F103F			Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	187						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GAGTTCAAGAGAACTTCCCAG	0.473000													28	90					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535791	69535791	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69535791C>T	ENST00000338206.5	-	1	555	c.546G>A	c.(544-546)gaG>gaA	p.E182E		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	182					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CACCATTCTTCTCAAATGTGT	0.398000													86	214					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220156210	220156210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220156210G>A	ENST00000295718.2	-	20	2951	c.2711C>T	c.(2710-2712)cCc>cTc	p.P904L	PTPRN_ENST00000497977.1_5'UTR|PTPRN_ENST00000423636.2_Missense_Mutation_p.P814L|PTPRN_ENST00000409251.3_Missense_Mutation_p.P875L	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	904	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CACGATGATGGGGCAGGAGCG	0.592000													14	39					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201185871	201185871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201185871G>A	ENST00000335211.4	+	16	9715	c.9585G>A	c.(9583-9585)gtG>gtA	p.V3195V	IGFN1_ENST00000295591.8_Silent_p.V355V	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGATATTGGTGGCTCCTGAGG	0.652000													20	53					0	0	1	0	0
GOLT1A	127845	broad.mit.edu	37	1	204172074	204172074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204172074G>A	ENST00000308302.3	-	2	252	c.67C>T	c.(67-69)Ctc>Ttc	p.L23F		NM_198447.1	NP_940849.1	Q6ZVE7	GOT1A_HUMAN	golgi transport 1A	23					protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane				kidney(1)|lung(2)|urinary_tract(1)	4	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			GTTCCAAAGAGGATGAAGAAG	0.567000													18	51					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56400068	56400068	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56400068G>A	ENST00000355701.3	-	9	2134	c.1264C>T	c.(1264-1266)Cgc>Tgc	p.R422C	BZRAP1_ENST00000268893.6_Missense_Mutation_p.R362C|BZRAP1_ENST00000343736.4_Missense_Mutation_p.R422C	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	422						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGGCTCTTGCGAAGGGCTGAG	0.657000													21	48					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94696948	94696948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94696948G>A	ENST00000304338.3	+	4	473	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K	PPP4R4_ENST00000555690.1_3'UTR	NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	107						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TGCAGGAGTGGAAATGCAGTT	0.393000													18	68					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103557528	103557528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103557528C>T	ENST00000424685.2	-	2	490	c.331G>A	c.(331-333)Gga>Aga	p.G111R	RELN_ENST00000343529.5_Missense_Mutation_p.G111R|RELN_ENST00000428762.1_Missense_Mutation_p.G111R			P78509	RELN_HUMAN	reelin	111	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.G111R(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTACCAAATCCGAAAGCACTG	0.388000													39	98					0	0	1	0	0
DIEXF	27042	broad.mit.edu	37	1	210001478	210001478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210001478C>T	ENST00000491415.2	+	1	127	c.70C>T	c.(70-72)Ctt>Ttt	p.L24F		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	24					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						GAAGAAACATCTTCGAGATTT	0.547000											OREG0014221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	61					0	0	1	0	0
TUBB3	10381	broad.mit.edu	37	16	90001895	90001895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:90001895C>T	ENST00000304984.5	+	3	3115	c.820C>T	c.(820-822)Ccc>Tcc	p.P274S	TUBB3_ENST00000315491.7_Missense_Mutation_p.P346S|TUBB3_ENST00000555576.1_Intron|TUBB3_ENST00000556922.1_Missense_Mutation_p.P693S|TUBB3_ENST00000554444.1_Missense_Mutation_p.P274S			Q13509	TBB3_HUMAN	tubulin, beta 3 class III	346					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGAGTGGATCCCCAACAACGT	0.612000													51	177					0	0	1	0	0
TIPARP	25976	broad.mit.edu	37	3	156395585	156395585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:156395585C>T	ENST00000461166.1	+	2	687	c.99C>T	c.(97-99)atC>atT	p.I33I	TIPARP_ENST00000542783.1_Silent_p.I33I|TIPARP_ENST00000486483.1_Silent_p.I33I|TIPARP_ENST00000295924.7_Silent_p.I33I	NM_001184717.1	NP_001171646.1	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	33							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CTGAGAAGATCACTCCATTGA	0.433000													20	147					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148921717	148921717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148921717C>T	ENST00000262085.3	+	8	2099	c.1994C>T	c.(1993-1995)cCg>cTg	p.P665L	ZNF282_ENST00000479907.1_3'UTR	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	665					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CGGCAGCTCCCGCCGCCTCCT	0.736000													4	10					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688457	60688457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:60688457C>T	ENST00000335712.6	-	4	1817	c.1590G>A	c.(1588-1590)cgG>cgA	p.R530R	BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Silent_p.R496R|BCL11A_ENST00000537768.1_Silent_p.R199R|BCL11A_ENST00000358510.4_Silent_p.R496R|BCL11A_ENST00000356842.4_Silent_p.R530R	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	530					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CGACCGCGCCCCGCGAGCTGT	0.697000			T	IGH@	B-CLL								6	12					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43683251	43683251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43683251C>T	ENST00000599812.1	-	3	584	c.489G>A	c.(487-489)gaG>gaA	p.E163E	PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407356.1_Intron|PSG5_ENST00000404580.1_Intron|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000342951.6_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	163	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				AGATCACAGCCTCCATGGCCT	0.527000													81	272					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100354555	100354555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100354555C>T	ENST00000273352.3	+	5	750	c.482C>T	c.(481-483)tCt>tTt	p.S161F	GPR128_ENST00000475887.1_5'UTR	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	161					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.S161F(1)		NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						AATAACATTTCTTCTGAAGTC	0.368000													18	88					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281892	49281892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:49281892G>A	ENST00000282018.3	+	1	942	c.939G>A	c.(937-939)aaG>aaA	p.K313K		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	313					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	AGAATTTTAAGGACAGACTAA	0.443000													34	67					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4833673	4833673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4833673C>T	ENST00000268231.8	-	6	870	c.607G>A	c.(607-609)Gag>Aag	p.E203K	SEPT12_ENST00000396693.5_Missense_Mutation_p.E157K	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	203					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						GCCTCTCGCTCCTCCATGGTC	0.687000													26	46					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237753151	237753151	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237753151G>A	ENST00000366574.2	+	30	3974	c.3657G>A	c.(3655-3657)aaG>aaA	p.K1219K	RYR2_ENST00000360064.6_Silent_p.K1217K|RYR2_ENST00000542537.1_Silent_p.K1203K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1219	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACTTTGGAAAGGATGTCAGCA	0.408000													14	45					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31374318	31374318	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31374318G>T	ENST00000328111.2	+	5	638	c.317G>T	c.(316-318)cGa>cTa	p.R106L	DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000344505.4_Missense_Mutation_p.R106L|DNMT3B_ENST00000375623.4_Intron|DNMT3B_ENST00000201963.3_Missense_Mutation_p.R118L|DNMT3B_ENST00000353855.2_Missense_Mutation_p.R106L|DNMT3B_ENST00000348286.2_Missense_Mutation_p.R106L|DNMT3B_ENST00000443239.3_Intron	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	106	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTCCGAACTCGAAATAACAAC	0.632000													18	54					1.87028e-06	1.87453e-06	1	1	0
USP11	8237	broad.mit.edu	37	X	47100963	47100963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:47100963C>T	ENST00000377107.2	+	9	1398	c.1044C>T	c.(1042-1044)tcC>tcT	p.S348S	USP11_ENST00000218348.3_Silent_p.S391S			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	391					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						ATTTTGCATCCCAATTTCTGG	0.547000													59	30					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19635037	19635037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19635037G>A	ENST00000235835.3	-	2	419	c.398C>T	c.(397-399)cCc>cTc	p.P133L		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	133					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTCCACTTGGGGACACTGCAG	0.602000													13	72					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143048907	143048907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143048907C>T	ENST00000343257.2	+	23	2903	c.2816C>T	c.(2815-2817)cCt>cTt	p.P939L		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	939					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CCAGAGCCCCCTCTCTCCCTG	0.647000													25	48					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110730466	110730466	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110730466C>T	ENST00000282356.4	+	5	843	c.445C>T	c.(445-447)Ctg>Ttg	p.L149L	CAMK4_ENST00000512453.1_Silent_p.L149L	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	149	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TAAACAAATCCTGGAGGCAGT	0.398000													30	39					0	0	1	0	0
DEFA6	1671	broad.mit.edu	37	8	6782352	6782352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:6782352G>A	ENST00000297436.2	-	2	331	c.291C>T	c.(289-291)ttC>ttT	p.F97F		NM_001926.3	NP_001917.1	Q01524	DEF6_HUMAN	defensin, alpha 6, Paneth cell-specific	97					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				lung(4)	4			STAD - Stomach adenocarcinoma(24;0.0322)	COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		AGAGGCAGCAGAATCTGTGGT	0.418000													7	82					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491720	100491720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100491720C>T	ENST00000302913.4	-	2	272	c.134G>A	c.(133-135)gGg>gAg	p.G45E	ACHE_ENST00000411582.1_Missense_Mutation_p.G45E|ACHE_ENST00000241069.5_Missense_Mutation_p.G45E|ACHE_ENST00000428317.1_Missense_Mutation_p.G45E|ACHE_ENST00000412389.1_Missense_Mutation_p.G45E|ACHE_ENST00000419336.2_Missense_Mutation_p.G45E	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	45					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CAGCCGGCCCCCACGCACCGT	0.692000													3	15					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81239646	81239646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81239646C>T	ENST00000552864.1	-	4	548	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	116	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						CCAAGGCCTTCATCAGTCTTT	0.458000													28	47					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159166837	159166837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159166837C>T	ENST00000368125.4	+	7	1096	c.939C>T	c.(937-939)acC>acT	p.T313T	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000368124.4_Silent_p.T347T|CADM3_ENST00000497636.1_3'UTR	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	313	Ig-like C2-type 2.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					CCTACTACACCCTCAATGTTA	0.488000													27	73					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108214637	108214637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108214637G>A	ENST00000273353.3	-	8	817	c.761C>T	c.(760-762)tCc>tTc	p.S254F		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	254	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AAAACGAGAGGAGTTGTCATT	0.338000													7	26					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95608714	95608714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95608714G>A	ENST00000395505.2	-	3	2339	c.2247C>T	c.(2245-2247)ttC>ttT	p.F749F	ZNF484_ENST00000332591.6_Silent_p.F749F|ZNF484_ENST00000375495.3_Silent_p.F785F|ANKRD19P_ENST00000473204.1_RNA|ZNF484_ENST00000395506.3_Silent_p.F787F	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	785					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						ATCTGATGGTGAAGGCCTTTC	0.398000													69	141					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585738	179585738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179585738C>T	ENST00000589042.1	-	79	23232	c.23008G>A	c.(23008-23010)Gaa>Aaa	p.E7670K	TTN_ENST00000342992.6_Missense_Mutation_p.E6426K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E7353K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7353	Ig-like 59.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACTAGCTTCATTGATCGTA	0.433000													32	78					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109318451	109318451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109318451C>T	ENST00000356711.2	+	2	306	c.180C>T	c.(178-180)ctC>ctT	p.L60L	MYO16_ENST00000251041.5_Silent_p.L60L|MYO16_ENST00000357550.2_Silent_p.L60L	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	60					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACTTCAACCTCACGGACATGC	0.433000													8	24					0	0	1	0	0
FSCN2	25794	broad.mit.edu	37	17	79495959	79495959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79495959C>T	ENST00000417245.2	+	1	538	c.402C>T	c.(400-402)caC>caT	p.H134H	FSCN2_ENST00000334850.7_Silent_p.H134H	NM_001077182.2|NM_012418.3	NP_001070650.1|NP_036550.1	O14926	FSCN2_HUMAN	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	134					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging			endometrium(1)|lung(1)|prostate(1)|urinary_tract(1)	4	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GGACCGTGCACCTGGCCATCC	0.711000													3	8					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73434899	73434899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73434899G>A	ENST00000224721.6	+	14	1500	c.1495G>A	c.(1495-1497)Gaa>Aaa	p.E499K	CDH23_ENST00000299366.7_Missense_Mutation_p.E539K	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	494	Cadherin 5.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CACCTTTGGGGAAGTCAGCTA	0.572000													10	34					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202593359	202593359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202593359G>A	ENST00000264276.6	-	15	3089	c.2717C>T	c.(2716-2718)tCc>tTc	p.S906F	ALS2_ENST00000457679.2_Missense_Mutation_p.S218F	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	906	PH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						CTTCCTCAAGGAATCCTGGAA	0.383000													24	54					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890533	23890533	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23890533G>C	ENST00000532292.1	-	1	642	c.548C>G	c.(547-549)tCc>tGc	p.S183C		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GACACTTGAGGAGGGAGCAAA	0.587000													5	56					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152325619	152325619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152325619C>T	ENST00000388718.5	-	3	4715	c.4643G>A	c.(4642-4644)gGa>gAa	p.G1548E	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1548							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGGTATCTCCTGTCTGTCC	0.473000													72	368					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123244952	123244952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123244952C>T	ENST00000358487.5	-	16	2424	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	FGFR2_ENST00000356226.4_Missense_Mutation_p.E601K|FGFR2_ENST00000351936.6_Missense_Mutation_p.E716K|FGFR2_ENST00000369056.1_Missense_Mutation_p.E719K|FGFR2_ENST00000369061.4_Missense_Mutation_p.E606K|FGFR2_ENST00000346997.2_Missense_Mutation_p.E716K|FGFR2_ENST00000360144.3_Missense_Mutation_p.E630K|FGFR2_ENST00000369060.4_Missense_Mutation_p.E602K|FGFR2_ENST00000457416.2_Missense_Mutation_p.E719K|FGFR2_ENST00000357555.5_Missense_Mutation_p.E629K|FGFR2_ENST00000369059.1_Missense_Mutation_p.E604K|FGFR2_ENST00000478859.1_Missense_Mutation_p.E490K	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	718	Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CTGTGTCCTTCCTTCAGCAGC	0.537000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				50	118					0	0	1	0	0
AADACL2	344752	broad.mit.edu	37	3	151474779	151474779	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151474779G>A	ENST00000356517.3	+	5	712		c.e5-1		RP11-454C18.2_ENST00000483843.2_RNA|RP11-454C18.2_ENST00000475855.1_RNA	NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2							extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TATATTTTCAGGTGCAGAATG	0.303000													26	52					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168621	142168621	+	RNA	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142168621T>A	ENST00000454561.2	-	0	302																											CTTGCTGTCCTCTCGTTTTGA	0.547000													20	84					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547747	63547747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:63547747G>A	ENST00000397968.2	+	12	2401	c.1975G>A	c.(1975-1977)Gga>Aga	p.G659R	CDH7_ENST00000323011.3_Missense_Mutation_p.G659R	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	659					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				CGAGGGCGGGGGAGAGGAGGA	0.478000													23	70					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55939061	55939061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55939061G>A	ENST00000244728.5	-	20	2331	c.1934C>T	c.(1933-1935)tCa>tTa	p.S645L	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.S45L|COL21A1_ENST00000535941.1_Missense_Mutation_p.S645L|COL21A1_ENST00000370819.1_Missense_Mutation_p.S642L	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	645	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTGGCCTGGTGAGCCATTGCT	0.333000													20	112					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149453010	149453010	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149453010C>T	ENST00000286301.3	-	7	1227	c.936G>A	c.(934-936)gaG>gaA	p.E312E	CSF1R_ENST00000543093.1_Intron	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	312	Ig-like C2-type 4.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CCACGGTCACCTCCTGGATGA	0.532000													44	116					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130509442	130509442	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130509442G>A	ENST00000314830.8	-	6	1361	c.1248C>T	c.(1246-1248)tcC>tcT	p.S416S	SH2D3C_ENST00000429553.1_Silent_p.S62S|SH2D3C_ENST00000373274.3_Silent_p.S256S|SH2D3C_ENST00000420366.1_Silent_p.S258S|SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Silent_p.S259S|SH2D3C_ENST00000373276.3_Silent_p.S348S	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	416					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGTAGGCAGGGGAGCTAGGGC	0.597000													16	88					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588598	247588598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247588598C>T	ENST00000366497.2	+	4	2633	c.1853C>T	c.(1852-1854)gCt>gTt	p.A618V	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Missense_Mutation_p.A618V|NLRP3_ENST00000336119.3_Missense_Mutation_p.A618V|NLRP3_ENST00000348069.2_Missense_Mutation_p.A618V|NLRP3_ENST00000391828.3_Missense_Mutation_p.A618V|NLRP3_ENST00000391827.2_Missense_Mutation_p.A618V	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	618					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding	p.A618V(1)		NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AAAGCCAAAGCTAAAAAGCTG	0.483000													16	51					0	0	1	0	0
C9orf152	401546	broad.mit.edu	37	9	112963360	112963360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112963360G>A	ENST00000400613.4	-	2	1197	c.588C>T	c.(586-588)ttC>ttT	p.F196F	C9orf152_ENST00000473442.1_Intron	NM_001012993.2	NP_001013011.2	Q5JTZ5	CI152_HUMAN	chromosome 9 open reading frame 152	196										NS(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						ATTGAGTGCTGAATTTTAAGC	0.502000													12	85					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92102845	92102845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92102845G>A	ENST00000256343.3	-	17	1822	c.1666C>T	c.(1666-1668)Cct>Tct	p.P556S		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	556					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TCGTTCTCAGGTACATATGCA	0.413000													15	76					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157959797	157959797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157959797G>A	ENST00000389413.3	-	6	839	c.736C>T	c.(736-738)Ctc>Ttc	p.L246F	PTPRN2_ENST00000389416.4_Missense_Mutation_p.L229F|PTPRN2_ENST00000404321.2_Missense_Mutation_p.L269F|PTPRN2_ENST00000389418.4_Missense_Mutation_p.L246F|PTPRN2_ENST00000409483.1_Missense_Mutation_p.L208F	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	246						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TAGGCACTGAGGGCCGCCATC	0.667000													5	29					0	0	1	0	0
ZNF850	342892	broad.mit.edu	37	19	37240729	37240729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37240729G>A	ENST00000591344.1	-	5	1371	c.1213C>T	c.(1213-1215)Cgc>Tgc	p.R405C	ZNF850_ENST00000589390.1_Intron	NM_001193552.1|NM_001267779.1	NP_001180481.1|NP_001254708.1	A8MQ14	ZN850_HUMAN	zinc finger protein 850	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										AACCCTGAGCGAAAAGTAAAA	0.383000													9	9					0	0	1	0	0
INPP5J	27124	broad.mit.edu	37	22	31524554	31524554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31524554C>T	ENST00000331075.5	+	9	2156	c.2107C>T	c.(2107-2109)Ctc>Ttc	p.L703F	INPP5J_ENST00000404453.1_Missense_Mutation_p.L68F|INPP5J_ENST00000400294.2_Missense_Mutation_p.L336F|INPP5J_ENST00000405300.1_Missense_Mutation_p.L336F|INPP5J_ENST00000401755.1_Missense_Mutation_p.L68F|INPP5J_ENST00000412277.2_Missense_Mutation_p.L636F|INPP5J_ENST00000404390.3_Missense_Mutation_p.L335F|INPP5J_ENST00000402238.1_Missense_Mutation_p.L68F			Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J	703	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	12						GAGCCACCGACTCCAGGTGAC	0.607000													27	53					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102707	22102707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22102707G>A	ENST00000542433.1	-	1	389	c.292C>T	c.(292-294)Ccg>Tcg	p.P98S		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CCACCAAACGGGATAGCCTTG	0.498000													20	36					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125555862	125555862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125555862C>T	ENST00000431078.1	+	19	3543	c.3179C>T	c.(3178-3180)tCt>tTt	p.S1060F		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1060	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		AATTCTTCTTCTCAGGACTTC	0.498000													7	49					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72937552	72937552	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72937552G>A	ENST00000328801.4	+	2	138	c.138G>A	c.(136-138)aaG>aaA	p.K46K		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	46						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CCCCGGAGAAGGAGAACCGAG	0.642000													6	15					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154067584	154067584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154067584C>T	ENST00000368559.3	-	15	2085	c.2014G>A	c.(2014-2016)Gaa>Aaa	p.E672K	NUP210L_ENST00000271854.3_Missense_Mutation_p.E672K	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	672						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AATACCATTTCCTTCACAGAC	0.408000													21	40					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66204583	66204583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:66204583C>T	ENST00000503581.1	-	4	1258	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	EYS_ENST00000393380.2_Missense_Mutation_p.E241K|EYS_ENST00000370616.2_Missense_Mutation_p.E241K|EYS_ENST00000370618.3_Missense_Mutation_p.E241K|EYS_ENST00000370621.3_Missense_Mutation_p.E241K|EYS_ENST00000342421.5_Missense_Mutation_p.E241K	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	241	EGF-like 2.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CAGACACATTCATATGCTTGC	0.299000													5	9					0	0	1	0	0
GDF11	10220	broad.mit.edu	37	12	56137461	56137461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56137461G>A	ENST00000257868.5	+	1	398	c.361G>A	c.(361-363)Ggc>Agc	p.G121S		NM_005811.3	NP_005802.1	O95390	GDF11_HUMAN	growth differentiation factor 11	121					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|urinary_tract(1)	12						CGACTTCCAGGGCGACGCGCT	0.667000													16	19					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189868140	189868140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189868140C>T	ENST00000304636.3	+	37	2727	c.2557C>T	c.(2557-2559)Cct>Tct	p.P853S	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	853	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CATATAGGGTCCTCCTGGTCC	0.383000													14	43					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508103	37508103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37508103G>A	ENST00000374660.1	+	40	3751	c.3652G>A	c.(3652-3654)Gaa>Aaa	p.E1218K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1099K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1099K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1170						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ACTGAAAGAGGAATCATTAAC	0.338000													69	167					0	0	1	0	0
ASZ1	136991	broad.mit.edu	37	7	117021086	117021086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117021086C>T	ENST00000284629.2	-	9	986	c.924G>A	c.(922-924)atG>atA	p.M308I		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	308	SAM.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CATCTTCCCTCATGGTCAAAA	0.308000													48	240					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	50816186	50816186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50816186G>A	ENST00000266037.9	+	2	141	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	40	SH3.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGAAAAATGTGAAGGTGAGTA	0.348000													3	6					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158627485	158627485	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158627485C>T	ENST00000368148.3	-	19	2768		c.e19-1		SPTA1_ENST00000368147.3_Splice_Site	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GCAAAGTGTCCTATGGAGTAA	0.413000													31	88					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38516566	38516566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38516566G>A	ENST00000356264.2	-	6	615	c.400C>T	c.(400-402)Cgc>Tgc	p.R134C	AMPH_ENST00000428293.2_Missense_Mutation_p.R134C|AMPH_ENST00000325590.5_Missense_Mutation_p.R134C	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	134	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						TTGGCGATGCGATTCTGTCAA	0.522000													19	60					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17943349	17943349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17943349G>A	ENST00000458235.1	-	19	2758	c.2659C>T	c.(2659-2661)Cgt>Tgt	p.R887C	JAK3_ENST00000534444.1_Missense_Mutation_p.R887C|JAK3_ENST00000527670.1_Missense_Mutation_p.R887C	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	887	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.R887C(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						CTGACACCACGATACTTGACA	0.547000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								21	108					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38991718	38991718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38991718C>T	ENST00000302328.3	-	1	334	c.136G>A	c.(136-138)Gaa>Aaa	p.E46K	SCN11A_ENST00000456224.3_Missense_Mutation_p.E46K|SCN11A_ENST00000444237.2_Missense_Mutation_p.E46K|SCN11A_ENST00000450244.1_Missense_Mutation_p.E46K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	46					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGGGGTACTTCTCCTGTCTGG	0.527000													85	143					0	0	1	0	0
PAOX	196743	broad.mit.edu	37	10	135197711	135197711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:135197711C>T	ENST00000278060.5	+	4	1199	c.1116C>T	c.(1114-1116)gcC>gcT	p.A372A	PAOX_ENST00000368535.2_3'UTR|PAOX_ENST00000368539.4_3'UTR|PAOX_ENST00000480071.2_Intron|PAOX_ENST00000357296.3_Silent_p.A372A	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	510					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TCCTGCCTGCCTTTGCGTACG	0.587000													39	95					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102645	22102645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22102645G>A	ENST00000542433.1	-	1	451	c.354C>T	c.(352-354)ttC>ttT	p.F118F		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AGGTGTAGAGGAAGCACTGGG	0.502000													10	22					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112969698	112969698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112969698C>T	ENST00000485230.1	+	4	1019	c.394C>T	c.(394-396)Cct>Tct	p.P132S	BOC_ENST00000355385.3_Intron|BOC_ENST00000273395.4_Intron|BOC_ENST00000484034.1_Missense_Mutation_p.P132S|BOC_ENST00000495514.1_Intron			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	834	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			TGCTCCTTTGCCTCCCTGCCA	0.602000													11	21					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19136816	19136816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19136816G>A	ENST00000601879.1	-	3	638	c.341C>T	c.(340-342)tCt>tTt	p.S114F	SUGP2_ENST00000337018.6_Missense_Mutation_p.S114F|SUGP2_ENST00000452918.2_Missense_Mutation_p.S114F|SUGP2_ENST00000598202.1_5'UTR|SUGP2_ENST00000456085.2_Missense_Mutation_p.L16F|SUGP2_ENST00000600377.1_Missense_Mutation_p.S128F			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	114					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						ATCAGAGTGAGAAAATTCCAG	0.502000													44	73					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540322	133540322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133540322G>A	ENST00000409261.1	-	14	4435	c.4062C>T	c.(4060-4062)agC>agT	p.S1354S	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Silent_p.S1354S	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1354							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						AGCTGCCTGAGCTCCCCAGGG	0.617000													14	31					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233769	21233769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21233769C>T	ENST00000233242.1	-	26	6098	c.5971G>A	c.(5971-5973)Gaa>Aaa	p.E1991K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1991					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGCTGTATTCATTGTTGTTA	0.463000													31	95					0	0	1	0	0
FAM3B	54097	broad.mit.edu	37	21	42694776	42694776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42694776G>A	ENST00000398646.3	+	1	30	c.15G>A	c.(13-15)agG>agA	p.R5R	FAM3B_ENST00000398652.3_Intron|FAM3B_ENST00000398647.3_Intron|FAM3B_ENST00000357985.2_Intron|FAM3B_ENST00000479810.2_Intron			P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	0					apoptosis|insulin secretion	extracellular space	cytokine activity			central_nervous_system(2)|endometrium(1)|lung(2)	5		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				AAAGCCACAGGGGGGATGGGG	0.647000													12	17					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5457844	5457844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:5457844C>T	ENST00000296564.7	+	12	1313	c.1091C>T	c.(1090-1092)tCa>tTa	p.S364L		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	364	Pro-rich.									breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						TTACCGTCTTCATTTGCACCT	0.463000													80	250					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299400	58299400	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58299400G>A	ENST00000377918.3	+	4	3478	c.3452G>A	c.(3451-3453)gGa>gAa	p.G1151E		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1151					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GACTGCCGGGGAAACGACCCT	0.448000													14	157					0	0	1	0	0
CHAMP1	283489	broad.mit.edu	37	13	115090016	115090016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:115090016C>T	ENST00000361283.1	+	3	1008	c.699C>T	c.(697-699)ttC>ttT	p.F233F		NM_001164144.1|NM_001164145.1|NM_032436.2	NP_001157616.1|NP_001157617.1|NP_115812.1	Q96JM3	ZN828_HUMAN	chromosome alignment maintaining phosphoprotein 1	233	Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding										AGTCTCATTTCCCGGAAACAT	0.532000													9	156					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947048	237947048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237947048G>A	ENST00000366574.2	+	90	12353	c.12036G>A	c.(12034-12036)atG>atA	p.M4012I	RYR2_ENST00000360064.6_Missense_Mutation_p.M4018I|RYR2_ENST00000542537.1_Missense_Mutation_p.M3996I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4012					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGTGGAGATGATTCTCAAAT	0.383000													6	21					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12939536	12939536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12939536G>A	ENST00000393233.2	-	5	725	c.176C>T	c.(175-177)gCt>gTt	p.A59V	RTBDN_ENST00000589272.1_Silent_p.R132R|RTBDN_ENST00000592204.1_Silent_p.R110R|RTBDN_ENST00000458671.2_Silent_p.R100R|RTBDN_ENST00000322912.5_Silent_p.R132R|CTD-2265O21.3_ENST00000588469.1_RNA	NM_001270440.1	NP_001257369.1	Q9BSG5	RTBDN_HUMAN	retbindin	0						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						GCAGGCGGAAGCGACTGCGAA	0.652000													15	88					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36888828	36888828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36888828C>T	ENST00000301807.6	-	15	5012	c.3115G>A	c.(3115-3117)Gaa>Aaa	p.E1039K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E1589K|TRANK1_ENST00000428977.2_Missense_Mutation_p.E1039K|TRANK1_ENST00000463984.1_5'UTR	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1589					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ATCTTCCATTCCTTATAAGCC	0.443000													6	28					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7059991	7059991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7059991G>A	ENST00000299481.4	+	2	520	c.174G>A	c.(172-174)ctG>ctA	p.L58L		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	58	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GGGAGGACCTGGCCAATTTGA	0.458000													18	82					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13660436	13660436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13660436G>A	ENST00000404922.3	+	7	2091	c.1972G>A	c.(1972-1974)Gag>Aag	p.E658K	FBLN2_ENST00000295760.7_Missense_Mutation_p.E658K|FBLN2_ENST00000535798.1_Missense_Mutation_p.E684K|FBLN2_ENST00000492059.1_Missense_Mutation_p.E658K	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	658						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGCCCCACAGGAGCCTGCACT	0.602000													6	25					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192950	132192950	+	Missense_Mutation	SNP	G	G	A	rs141998123		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:132192950G>A	ENST00000359827.3	-	2	1465	c.503C>T	c.(502-504)tCa>tTa	p.S168L	PLXNA4_ENST00000423507.2_Missense_Mutation_p.S168L|PLXNA4_ENST00000378539.5_Missense_Mutation_p.S168L|PLXNA4_ENST00000321063.4_Missense_Mutation_p.S168L			Q9HCM2	PLXA4_HUMAN	plexin A4	168	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCCAAAGACTGAGCCGCTCTC	0.542000													21	68					0	0	1	0	0
YIF1B	90522	broad.mit.edu	37	19	38799639	38799639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38799639G>A	ENST00000392124.3	-	3	682	c.368C>T	c.(367-369)gCc>gTc	p.A123V	YIF1B_ENST00000587361.1_5'UTR|YIF1B_ENST00000592694.1_Missense_Mutation_p.A123V|YIF1B_ENST00000591784.1_Missense_Mutation_p.A123V|YIF1B_ENST00000339413.6_Missense_Mutation_p.A154V|YIF1B_ENST00000337679.8_Missense_Mutation_p.A151V|YIF1B_ENST00000329420.8_Missense_Mutation_p.A139V|YIF1B_ENST00000591755.1_Missense_Mutation_p.A151V|YIF1B_ENST00000592246.1_Missense_Mutation_p.A88V	NM_033557.3	NP_291035.1	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B (S. cerevisiae)	154						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)	10	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GAGGTCCGGGGCATTGACGTC	0.657000													4	12					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70978497	70978497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70978497C>T	ENST00000276594.2	-	5	1357	c.1156G>A	c.(1156-1158)Ggg>Agg	p.G386R		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GGCTGCTTCCCCGGCTCTGTG	0.537000													8	73					0	0	1	0	0
C8orf86	389649	broad.mit.edu	37	8	38370085	38370085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:38370085G>A	ENST00000437935.2	-	2	338	c.319C>T	c.(319-321)Ccg>Tcg	p.P107S	C8orf86_ENST00000358138.1_Silent_p.L164L			Q6ZUL3	CH086_HUMAN	chromosome 8 open reading frame 86	0										breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						gaggactgcggaggcttgaga	0.537000													7	76					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40076668	40076668	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40076668G>A	ENST00000324616.5	+	8	1096	c.942G>A	c.(940-942)agG>agA	p.R314R	C12orf40_ENST00000405531.3_Silent_p.R314R|C12orf40_ENST00000398716.1_Silent_p.R237R	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	314								p.R314R(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						ATGAGCAAAGGATAAAGAAAA	0.328000													18	56					0	0	1	0	0
SNX1	6642	broad.mit.edu	37	15	64404804	64404804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:64404804C>T	ENST00000353874.4	+	2	228	c.192C>T	c.(190-192)tcC>tcT	p.S64S	SNX1_ENST00000261889.5_Silent_p.S64S|SNX1_ENST00000561026.1_Silent_p.S64S|SNX1_ENST00000560829.1_5'UTR|SNX1_ENST00000559844.1_Silent_p.S64S			Q13596	SNX1_HUMAN	sorting nexin 1	64					cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13						TAACTACATCCCTTCTTCCCA	0.393000													8	124					0	0	1	0	0
OR52N5	390075	broad.mit.edu	37	11	5798909	5798909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5798909C>T	ENST00000317093.2	-	1	988	c.956G>A	c.(955-957)gGt>gAt	p.G319D	TRIM5_ENST00000380027.1_Intron	NM_001001922.2	NP_001001922.2	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N, member 5	319					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(1)|lung(17)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ACCCTTATCACCCTGGAAGAA	0.343000													40	25					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26694976	26694976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26694976C>T	ENST00000529632.2	+	5	1385	c.1189C>T	c.(1189-1191)Cgc>Tgc	p.R397C	SEZ6L_ENST00000343706.4_Missense_Mutation_p.R397C|SEZ6L_ENST00000360929.3_Missense_Mutation_p.R397C|SEZ6L_ENST00000404234.3_Missense_Mutation_p.R397C|SEZ6L_ENST00000248933.6_Missense_Mutation_p.R397C|SEZ6L_ENST00000402979.1_Missense_Mutation_p.R170C|SEZ6L_ENST00000403121.1_Missense_Mutation_p.R170C	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	397	Sushi 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CAACTTTCCCCGCCGGCCTGA	0.582000													20	49					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	62038627	62038627	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:62038627C>T	ENST00000280772.1	-	4	510	c.319G>A	c.(319-321)Gga>Aga	p.G107R	ANK3_ENST00000503366.1_Missense_Mutation_p.G90R|ANK3_ENST00000373827.2_Missense_Mutation_p.G101R	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	107					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCTGTGTTTCCTTTCTGTGAA	0.383000													35	105					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55266508	55266508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55266508C>T	ENST00000275493.2	+	23	2977	c.2800C>T	c.(2800-2802)Cct>Tct	p.P934S	EGFR_ENST00000454757.2_Missense_Mutation_p.P881S|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_Missense_Mutation_p.P889S	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	934	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AGAACGCCTCCCTCAGCCACC	0.542000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			15	58					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29142037	29142037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29142037C>T	ENST00000377167.2	+	1	727	c.625C>T	c.(625-627)Ctc>Ttc	p.L209F		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CATTTTTGTTCTCATACCTCT	0.468000													34	114					0	0	1	0	0
SERPINA11	256394	broad.mit.edu	37	14	94915077	94915077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94915077C>T	ENST00000334708.3	-	2	99	c.35G>A	c.(34-36)gGg>gAg	p.G12E	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	12					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		GGCCAGGATCCCTGTTCCCAG	0.522000													30	91					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39409223	39409223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39409223C>T	ENST00000257408.4	+	1	751	c.654C>T	c.(652-654)ttC>ttT	p.F218F		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	218	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						TAGATATCTTCAATGACTATG	0.393000													41	107					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	13357153	13357153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:13357153C>T	ENST00000276297.4	-	2	837	c.428G>A	c.(427-429)gGa>gAa	p.G143E	DLC1_ENST00000511869.1_Missense_Mutation_p.G143E|DLC1_ENST00000316609.5_Missense_Mutation_p.G143E	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	143					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GGAGCCTGCTCCTTGGATCAT	0.408000													79	149					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55948773	55948773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55948773C>T	ENST00000263923.4	-	28	3987	c.3692G>A	c.(3691-3693)aGc>aAc	p.S1231N	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1231					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACAGGCCGGCTCTTTCGCTT	0.358000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			20	112					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179486330	179486330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179486330C>T	ENST00000589042.1	-	245	45445	c.45221G>A	c.(45220-45222)gGa>gAa	p.G15074E	TTN_ENST00000342992.6_Missense_Mutation_p.G12506E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G6009E|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G6201E|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G6134E|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G13433E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13433	Fibronectin type-III 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATATCTTCCTGTTTCAAT	0.443000													33	72					0	0	1	0	0
SLC30A2	7780	broad.mit.edu	37	1	26365705	26365705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26365705C>T	ENST00000374278.3	-	7	1134	c.918G>A	c.(916-918)gaG>gaA	p.E306E	SLC30A2_ENST00000374276.3_Silent_p.E355E	NM_032513.3	NP_115902.1	Q9BRI3	ZNT2_HUMAN	solute carrier family 30 (zinc transporter), member 2	306					positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity			cervix(1)|endometrium(2)|kidney(1)|lung(8)|stomach(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		CCGAGTAGTCCTCGATCTGGA	0.612000													4	35					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935849	30935849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30935849G>A	ENST00000355537.3	+	2	1527	c.1380G>A	c.(1378-1380)atG>atA	p.M460I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGCTGCCCATGAAGGAGAAGG	0.642000													15	55					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64603064	64603064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64603064C>T	ENST00000342711.5	-	15	1787	c.1788G>A	c.(1786-1788)ggG>ggA	p.G596G		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	596					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GGGGTCCCATCCCGTTGGTCT	0.667000													20	94					0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132912248	132912248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132912248C>T	ENST00000409867.1	-	4	850	c.601G>A	c.(601-603)Gat>Aat	p.D201N	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like											endometrium(1)|kidney(3)	4						TTAAACTTATCAACTGCATTT	0.308000													3	17					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	91994072	91994072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91994072G>A	ENST00000450295.1	-	16	2912	c.2136C>T	c.(2134-2136)atC>atT	p.I712I	SEMA4D_ENST00000356444.2_Silent_p.I712I|SEMA4D_ENST00000339861.4_Intron|SEMA4D_ENST00000438547.2_Silent_p.I712I|SEMA4D_ENST00000455551.2_Intron|SEMA4D_ENST00000422704.2_Silent_p.I712I|SEMA4D_ENST00000420987.1_Intron|SEMA4D_ENST00000343780.4_Intron			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	712					anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						TGTTGATGACGATCTTTGGTT	0.597000													8	60					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38891888	38891888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38891888C>T	ENST00000359357.3	+	71	10515	c.10261C>T	c.(10261-10263)Cct>Tct	p.P3421S	RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.P3638S|DNAH8_ENST00000441566.1_Missense_Mutation_p.P3385S|RP1-207H1.3_ENST00000418399.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACGGAAAATTCCTTTCACAGA	0.363000													7	91					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131976432	131976432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131976432C>T	ENST00000356920.5	+	1	551	c.457C>T	c.(457-459)Ccc>Tcc	p.P153S	POTEE_ENST00000358087.5_Missense_Mutation_p.P153S|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	153							ATP binding	p.P153S(2)									GGGTAAAGTCCCCAGAAAGGA	0.572000													36	194					0	0	1	0	0
CD300C	10871	broad.mit.edu	37	17	72540779	72540779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72540779G>A	ENST00000330793.1	-	2	729	c.369C>T	c.(367-369)ccC>ccT	p.P123P		NM_006678.3	NP_006669.1	Q08708	CLM6_HUMAN	CD300c molecule	123	Ig-like V-type.|Pro-rich.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						CCTCGACAATGGGATCATGAA	0.577000													15	53					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26636735	26636735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:26636735G>A	ENST00000381340.3	-	42	6324	c.5908C>T	c.(5908-5910)Ctg>Ttg	p.L1970L		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1970					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					AACAGGCCCAGGCCACCGGTT	0.468000													23	176					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1444083	1444083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:1444083G>A	ENST00000446702.2	+	22	3526	c.2899G>A	c.(2899-2901)Gaa>Aaa	p.E967K	CNTN6_ENST00000539053.1_Missense_Mutation_p.E895K|CNTN6_ENST00000350110.2_Missense_Mutation_p.E967K			Q9UQ52	CNTN6_HUMAN	contactin 6	967	Fibronectin type-III 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GGTTCCATTTGAAGAAGACTA	0.368000													16	73					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77950759	77950759	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77950759G>A	ENST00000393684.3	-	4	661	c.270C>T	c.(268-270)ccC>ccT	p.P90P	ISM2_ENST00000429906.1_Silent_p.P97P|ISM2_ENST00000412904.1_Intron|ISM2_ENST00000493585.1_Silent_p.P178P|ISM2_ENST00000342219.4_Silent_p.P178P			Q6H9L7	ISM2_HUMAN	isthmin 2	178						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						CCTGGGTCCTGGGAGGCGTGG	0.592000													10	105					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176798994	176798994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176798994C>T	ENST00000408923.3	+	15	1807	c.1619C>T	c.(1618-1620)tCc>tTc	p.S540F	RGS14_ENST00000506944.1_3'UTR	NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	540					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGCCCAGCTCCGAGGAGACC	0.632000													35	344					0	0	1	0	0
GSPT2	23708	broad.mit.edu	37	X	51487060	51487060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:51487060C>T	ENST00000340438.4	+	1	580	c.338C>T	c.(337-339)tCc>tTc	p.S113F		NM_018094.4	NP_060564.2	Q8IYD1	ERF3B_HUMAN	G1 to S phase transition 2	113					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Ovarian(276;0.236)					GTGGAACCTTCCCGAGAGGAA	0.572000													7	4					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15262433	15262433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15262433C>T	ENST00000256953.2	-	5	547	c.211G>A	c.(211-213)Gag>Aag	p.E71K	RERG_ENST00000546331.1_Missense_Mutation_p.E52K|RERG_ENST00000538313.1_Missense_Mutation_p.E71K|RERG_ENST00000536465.1_Missense_Mutation_p.E71K	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	71					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						ATGTGCCCCTCCCTCTGAATG	0.463000													84	371					0	0	1	0	0
FAM107A	11170	broad.mit.edu	37	3	58552332	58552332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58552332C>T	ENST00000394481.1	-	5	976	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	FAM107A_ENST00000464064.1_3'UTR|FAM107A_ENST00000447756.2_Missense_Mutation_p.E168K|FAM107A_ENST00000474531.1_Missense_Mutation_p.E171K|FAM107A_ENST00000360997.2_Missense_Mutation_p.E140K	NM_007177.2	NP_009108.1	O95990	F107A_HUMAN	family with sequence similarity 107, member A	140					regulation of cell growth	nucleus	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(55;0.000189)|Kidney(10;0.000536)|KIRC - Kidney renal clear cell carcinoma(10;0.000716)|OV - Ovarian serous cystadenocarcinoma(275;0.154)		TCTCTCTCTTCGCTGGTCAGT	0.602000													10	103					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32891130	32891130	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32891130G>A	ENST00000330048.5	-	0	2925					NR_003083.2																						CAGTCACCATGGAGAGATCAA	0.597000													26	101					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834206	101834206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101834206G>A	ENST00000506729.1	-	1	514	c.343C>T	c.(343-345)Ctg>Ttg	p.L115L	SLCO6A1_ENST00000379810.1_Silent_p.L115L|SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000513675.1_Silent_p.L115L|SLCO6A1_ENST00000389019.3_Silent_p.L115L|SLCO6A1_ENST00000379807.3_Silent_p.L115L			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	115	Cys-rich.					integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CATATGAGCAGGATGCAGTAG	0.572000													21	49					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74536339	74536339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74536339C>T	ENST00000398814.3	+	2	466	c.35C>T	c.(34-36)cCa>cTa	p.P12L	CCDC33_ENST00000321288.5_Intron	NM_025055.3	NP_079331.3	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	215							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						ACTGAAGACCCAGAGGAGCCC	0.557000													20	153					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69472591	69472591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69472591C>T	ENST00000303714.4	+	18	1991	c.1669C>T	c.(1669-1671)Cgc>Tgc	p.R557C		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	557	Pro-rich.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						tcctccctcccgccctcctcc	0.622000									Familial Infantile Hemangioma				7	42					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819707	50819707	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50819707C>T	ENST00000374115.3	+	1	1361	c.921C>T	c.(919-921)ttC>ttT	p.F307F	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	307					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						CCCTCGCCTTCCTCGAACCCA	0.637000													48	77					0	0	1	0	0
SP3	6670	broad.mit.edu	37	2	174783444	174783444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:174783444G>A	ENST00000310015.6	-	5	2239	c.1709C>T	c.(1708-1710)aCc>aTc	p.T570I	SP3_ENST00000455789.2_Missense_Mutation_p.T517I|SP3_ENST00000418194.2_Missense_Mutation_p.T502I	NM_001172712.1|NM_003111.4	NP_001166183.1|NP_003102.1	Q02447	SP3_HUMAN	Sp3 transcription factor	570	Repressor domain.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	NS(2)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TAGGTCATTGGTATTCAAGGT	0.428000													44	113					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56349080	56349080	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56349080G>A	ENST00000340482.3	-	10	2238	c.2062C>T	c.(2062-2064)Cgc>Tgc	p.R688C	MPO_ENST00000225275.3_Missense_Mutation_p.R656C			P05164	PERM_HUMAN	myeloperoxidase	656					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GGGCCCACGCGGCCTTTGCGC	0.632000													13	36					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130845791	130845791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130845791G>A	ENST00000245255.3	+	15	2004	c.1732G>A	c.(1732-1734)Gat>Aat	p.D578N		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	578	Piwi.|RNA-binding (By similarity).				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CCTGTGTACAGATTGCCCTAC	0.433000													21	31					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26586932	26586932	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26586932C>T	ENST00000436318.2	-	2	688	c.555G>A	c.(553-555)gtG>gtA	p.V185V	ANO3_ENST00000537978.1_Intron|MUC15_ENST00000281268.8_Silent_p.V185V|MUC15_ENST00000529533.1_Silent_p.V185V|MUC15_ENST00000455601.2_Silent_p.V158V|ANO3_ENST00000531568.1_Intron|ANO3_ENST00000256737.3_Intron|ANO3_ENST00000525139.1_Intron|MUC15_ENST00000527569.1_Silent_p.V185V			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	158						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						CAGGAGTTTTCACGGTGTCAT	0.448000													49	120					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40944253	40944253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40944253C>T	ENST00000346991.5	+	22	6833	c.6443C>T	c.(6442-6444)aCc>aTc	p.T2148I	CASC5_ENST00000399668.2_Missense_Mutation_p.T2122I			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	2148	Necessary for kinetochore localization and for interaction with NSL1 and DSN1.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		GCTGTATTCACCTTTGTTTAT	0.358000													12	61					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032617	30032617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30032617C>T	ENST00000328224.6	-	2	2842	c.1609G>A	c.(1609-1611)Ggc>Agc	p.G537S		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	537						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						ACAATCTTGCCCCCTACAGTG	0.498000													9	66					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56403666	56403666	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56403666C>T	ENST00000355701.3	-	3	1428	c.558G>A	c.(556-558)acG>acA	p.T186T	BZRAP1-AS1_ENST00000579527.1_RNA|BZRAP1_ENST00000268893.6_Silent_p.T186T|BZRAP1_ENST00000343736.4_Silent_p.T186T	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	186						mitochondrion	benzodiazepine receptor binding	p.T186T(2)		cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCTCAGGTTCGTTTCCTGCA	0.632000													23	51					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113312259	113312259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113312259G>A	ENST00000401783.2	-	2	993	c.657C>T	c.(655-657)ttC>ttT	p.F219F	SVEP1_ENST00000374469.1_Silent_p.F196F|SVEP1_ENST00000374461.1_Silent_p.F196F|SVEP1_ENST00000302728.8_Silent_p.F219F|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	219	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TGCCAAAAGTGAAGATCTCCA	0.458000													13	54					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51370588	51370588	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51370588G>A	ENST00000266037.9	+	35	3538		c.e35-1			NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCCACCAATAGCCTGCTGGAG	0.522000													20	80					0	0	1	0	0
KIAA1328	57536	broad.mit.edu	37	18	34740344	34740344	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:34740344G>A	ENST00000591619.1	+	8	2188	c.1402_splice	c.e8+1	p.G468_splice	KIAA1328_ENST00000280020.5_Splice_Site_p.G472_splice|KIAA1328_ENST00000543923.1_Splice_Site_p.G364_splice|KIAA1328_ENST00000586135.1_Splice_Site_p.G224_splice|KIAA1328_ENST00000435985.2_Splice_Site_p.G224_splice			Q86T90	K1328_HUMAN	KIAA1328	472										central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	14				COAD - Colon adenocarcinoma(74;0.195)		ACCCCAAAGAGGTAAGTTTAA	0.408000													11	39					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869840	4869840	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4869840G>C	ENST00000322101.2	-	1	674	c.599C>G	c.(598-600)gCt>gGt	p.A200G	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCACCCCAAGCTTCTGGGCA	0.532000													32	91					0	0	1	0	0
LINC00842	643650	broad.mit.edu	37	10	47133588	47133588	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:47133588C>T	ENST00000422732.2	-	0	435					NR_033957.1																						gccaccatatccaccaccacc	0.483000													13	98					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185018422	185018422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:185018422C>T	ENST00000296741.2	-	7	1234	c.1093G>A	c.(1093-1095)Ggc>Agc	p.G365S		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	365					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		AGGAAGATGCCCCGCATGTCC	0.592000													15	80					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41137716	41137716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41137716G>A	ENST00000380588.4	+	3	458	c.355G>A	c.(355-357)Ggg>Agg	p.G119R	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	119	Ig-like V-type 1.					integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				CAGTGATTCGGGGAACATCAG	0.542000													15	21					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169780299	169780299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169780299C>T	ENST00000263817.6	-	28	3923	c.3799G>A	c.(3799-3801)Ggt>Agt	p.G1267S		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1267	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CAGGTCCGACCCTCTCTGGCT	0.527000													10	37					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927586	92927586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:92927586C>T	ENST00000373079.3	-	1	981	c.718G>A	c.(718-720)Gac>Aac	p.D240N	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	240	Glu-rich.				nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TCCATACAGTCTTTAGAATCT	0.418000													67	43					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899666	233899666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233899666C>T	ENST00000233840.3	+	2	1042	c.1042C>T	c.(1042-1044)Ccc>Tcc	p.P348S		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	348							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		TGATGGGTCCCCCTTGTTTGG	0.587000													78	181					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37536457	37536457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:37536457G>A	ENST00000299824.1	+	9	1096	c.907G>A	c.(907-909)Gag>Aag	p.E303K	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.E261K	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	303					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				AGACCTGTGCGAGGAGGAAGA	0.592000													32	58					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168180021	168180021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168180021C>T	ENST00000519560.1	-	18	2331	c.1912G>A	c.(1912-1914)Gac>Aac	p.D638N	SLIT3_ENST00000332966.8_Missense_Mutation_p.D638N|SLIT3_ENST00000404867.3_Missense_Mutation_p.D638N	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	638					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCCGATTGTCATAGAGGGAC	0.572000													12	37					0	0	1	0	0
OXCT2	64064	broad.mit.edu	37	1	40236066	40236066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40236066C>T	ENST00000327582.5	-	1	954	c.862G>A	c.(862-864)Gaa>Aaa	p.E288K	BMP8B_ENST00000397360.2_Intron|BMP8B_ENST00000372827.3_Intron	NM_022120.1	NP_071403.1	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2	288					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|pancreas(1)|upper_aerodigestive_tract(1)	6	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	TCTCCATCTTCCTCTTTCAGG	0.517000											OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	241					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61525396	61525396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61525396G>A	ENST00000266070.4	-	12	3048	c.2723C>T	c.(2722-2724)cCt>cTt	p.P908L	DIDO1_ENST00000395340.1_Missense_Mutation_p.P908L|DIDO1_ENST00000395335.2_Missense_Mutation_p.P908L|DIDO1_ENST00000395343.1_Missense_Mutation_p.P908L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	908					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GGCAACTTCAGGCACAGCCTC	0.532000													47	89					0	0	1	0	0
ANKRD13A	88455	broad.mit.edu	37	12	110463607	110463607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110463607G>A	ENST00000261739.4	+	8	1028	c.862G>A	c.(862-864)Gag>Aag	p.E288K		NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	288										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						TCTGACCGAGGAGGAAAAAAA	0.408000													43	94					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104341555	104341555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104341555C>T	ENST00000361820.3	-	7	3454	c.2854G>A	c.(2854-2856)Gag>Aag	p.E952K		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	952	PPP2CB binding site (By similarity).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ACTATGTGCTCACCAATGGTG	0.478000													8	44					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3313082	3313082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3313082G>A	ENST00000378398.3	+	6	686	c.604G>A	c.(604-606)Gag>Aag	p.E202K	PRDM16_ENST00000378391.2_Missense_Mutation_p.E201K|PRDM16_ENST00000270722.5_Missense_Mutation_p.E201K|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Missense_Mutation_p.E201K|PRDM16_ENST00000441472.2_Missense_Mutation_p.E201K|PRDM16_ENST00000514189.1_Missense_Mutation_p.E202K|PRDM16_ENST00000511072.1_Missense_Mutation_p.E202K			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	201	SET.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TAAGGACATTGAGCCAGGTGA	0.572000			T	EVI1	"""MDS, AML"""								5	13					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39149936	39149936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:39149936G>A	ENST00000297668.6	-	10	1589	c.1516C>T	c.(1516-1518)Ccc>Tcc	p.P506S	CNTNAP3_ENST00000377656.2_Missense_Mutation_p.P506S|CNTNAP3_ENST00000323947.7_Intron|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.P418S|CNTNAP3_ENST00000377659.1_Missense_Mutation_p.P506S	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	506	Laminin G-like 2.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CCTCCCAGGGGGCTTTTACAT	0.493000													15	48					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62257019	62257019	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62257019G>A	ENST00000371158.2	+	9	1182		c.e9-1		INADL_ENST00000316485.6_Splice_Site	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)						intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TTTCCTTTTAGGACAGTTCTC	0.338000													7	63					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74017761	74017761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74017761G>A	ENST00000301607.3	-	8	1162	c.909C>T	c.(907-909)ccC>ccT	p.P303P	EVPL_ENST00000586740.1_Silent_p.P303P	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	303	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						gcaccTGGATGGGCCCCACCG	0.721000													4	14					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28272835	28272835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28272835C>T	ENST00000305242.5	-	6	848	c.756G>A	c.(754-756)gtG>gtA	p.V252V	ARMC4_ENST00000239715.3_Silent_p.V109V	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	252							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						CGTGAGGTTTCACCAGCACAT	0.393000													27	57					0	0	1	0	0
SLC22A12	116085	broad.mit.edu	37	11	64368270	64368270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64368270C>T	ENST00000377574.1	+	9	2205	c.1458C>T	c.(1456-1458)gtC>gtT	p.V486V	SLC22A12_ENST00000377572.1_Silent_p.V378V|SLC22A12_ENST00000336464.7_Silent_p.V452V|SLC22A12_ENST00000473690.1_Silent_p.V265V|SLC22A12_ENST00000377567.2_Silent_p.V378V	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	486					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						GGCCTCTGGTCCGGCTGCTGG	0.657000													24	60					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57383352	57383352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57383352C>T	ENST00000361249.3	+	11	1814	c.1718C>T	c.(1717-1719)tCg>tTg	p.S573L		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	573	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGAGGGGCCTCGTGTCCAGGG	0.582000													21	55					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40719431	40719431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40719431C>T	ENST00000253055.3	+	9	2133	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	615					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						CAGAGGAGTTCGCGGAGGCAG	0.706000													8	37					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11067176	11067176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11067176C>T	ENST00000287766.4	+	8	1177	c.756C>T	c.(754-756)atC>atT	p.I252I	SLC6A1_ENST00000536032.1_Silent_p.I74I	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	252					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCATGCTGATCATCCTGTTCT	0.572000													22	35					0	0	1	0	0
TRBV11-1	28582	broad.mit.edu	37	7	142223992	142223992	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142223992C>T	ENST00000390367.3	-	0	191																											GGGCCCTGTCCCAGGATCTGC	0.488000													23	65					0	0	1	0	0
LRRC14	9684	broad.mit.edu	37	8	145745326	145745326	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145745326C>A	ENST00000292524.1	+	2	363	c.217C>A	c.(217-219)Cgt>Agt	p.R73S	LRRC14_ENST00000529022.1_Missense_Mutation_p.R73S	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	73										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CCACTGCAGCCGTGCCCTCCT	0.627000													16	68					2.35188e-11	2.36193e-11	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	79878690	79878690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79878690C>T	ENST00000466387.1	+	6	732	c.8C>T	c.(7-9)tCg>tTg	p.S3L	CTNNA2_ENST00000540488.1_Missense_Mutation_p.S3L|CTNNA2_ENST00000496558.1_Missense_Mutation_p.S3L|CTNNA2_ENST00000402739.4_Missense_Mutation_p.S3L|CTNNA2_ENST00000361291.4_Missense_Mutation_p.S37L|CTNNA2_ENST00000541047.1_Missense_Mutation_p.S3L|CTNNA2_ENST00000409266.1_Missense_Mutation_p.S3L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	3					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AGCATGACTTCGGCAACTTCA	0.403000													26	69					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16816494	16816494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:16816494C>T	ENST00000355661.3	-	18	2491	c.2481G>A	c.(2479-2481)gaG>gaA	p.E827E	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Silent_p.E827E|PLEKHA7_ENST00000448080.2_Silent_p.E827E			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	827					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TTCTGAAGTTCTCTTTATTTG	0.483000													73	171					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189012653	189012653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189012653G>A	ENST00000512729.1	-	7	1412	c.1038C>T	c.(1036-1038)tcC>tcT	p.S346S	TRIML2_ENST00000326754.3_Silent_p.S371S	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	346	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AGGCGCAATGGGAGAAATTGT	0.478000													51	105					0	0	1	0	0
PROK2	60675	broad.mit.edu	37	3	71821914	71821914	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:71821914C>T	ENST00000353065.3	-	3	441	c.288G>A	c.(286-288)cgG>cgA	p.R96R	PROK2_ENST00000295619.3_Silent_p.R117R	NM_021935.3	NP_068754.1	Q9HC23	PROK2_HUMAN	prokineticin 2	117					activation of MAPK activity|angiogenesis|anti-apoptosis|cell proliferation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response|neuropeptide signaling pathway|positive regulation of smooth muscle contraction|sensory perception of pain|spermatogenesis	extracellular region	G-protein-coupled receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.89e-05)|Epithelial(33;0.000173)|LUSC - Lung squamous cell carcinoma(21;0.00168)|Lung(16;0.00306)		TAAATGAAGTCCGTAAACAGG	0.418000													28	82					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111158883	111158883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111158883G>A	ENST00000360467.5	+	46	4830	c.4524G>A	c.(4522-4524)atG>atA	p.M1508I	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1508	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAGTGGGCATGAACAAACTCT	0.657000													12	15					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23898557	23898557	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23898557C>T	ENST00000355349.3	-	13	1301		c.e13-1			NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta						adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTGTCAGCCTCTGGAAGGAAA	0.557000													26	50					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103573705	103573705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103573705C>T	ENST00000358392.2	-	1	347	c.30G>A	c.(28-30)acG>acA	p.T10T	COL11A1_ENST00000370096.3_Silent_p.T10T|COL11A1_ENST00000512756.1_Silent_p.T10T|COL11A1_ENST00000353414.4_Silent_p.T10T	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	10					collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCCACCGTTTCGTTTTCCACC	0.522000													18	43					0	0	1	0	0
NAIP	4671	broad.mit.edu	37	5	70308413	70308413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:70308413C>T	ENST00000517649.1	-	4	620	c.330G>A	c.(328-330)acG>acA	p.T110T	NAIP_ENST00000503719.2_Intron|NAIP_ENST00000194097.4_Silent_p.T110T|NAIP_ENST00000508426.2_Silent_p.T110T|NAIP_ENST00000523981.1_Intron	NM_004536.2	NP_004527.2	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein	110					anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		TGGGGAGTCTCGTGAGGCCGG	0.493000													26	113					0	0	1	0	0
MS4A3	932	broad.mit.edu	37	11	59830030	59830030	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59830030C>T	ENST00000278865.3	+	3	319	c.246C>T	c.(244-246)ttC>ttT	p.F82F	MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000358152.2_Intron|MS4A3_ENST00000534744.1_Intron	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	82	Poly-Phe.					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				AAAAGCACTTCTTTTTCTTCA	0.453000													53	116					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155340754	155340754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155340754G>A	ENST00000368346.3	-	11	7007	c.6368C>T	c.(6367-6369)tCc>tTc	p.S2123F	ASH1L_ENST00000392403.3_Missense_Mutation_p.S2118F			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	2123	AWS.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			AGTGTTGGGGGAACACTCAGC	0.393000													20	50					0	0	1	0	0
KLHL30	377007	broad.mit.edu	37	2	239049585	239049585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239049585G>A	ENST00000409223.1	+	2	297	c.190G>A	c.(190-192)Ggt>Agt	p.G64S	KLHL30_ENST00000305959.4_Missense_Mutation_p.G46S			Q0D2K2	KLH30_HUMAN	kelch-like family member 30	64	BTB.									lung(4)	4		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CATGTTTGCGGGTGACTTCGC	0.682000													9	175					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43945658	43945658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43945658C>T	ENST00000389420.3	-	1	66	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E23K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	23						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAGTCAACTTCCCAAGACCTG	0.652000													22	83					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33623571	33623571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33623571C>T	ENST00000374316.5	+	4	1249	c.189C>T	c.(187-189)aaC>aaT	p.N63N	ITPR3_ENST00000605930.1_Silent_p.N63N			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	63					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GCCCCATGAACCGCTACTCGG	0.582000													5	48					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53012266	53012266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53012266C>T	ENST00000305748.3	-	1	77	c.43G>A	c.(43-45)Ggg>Agg	p.G15R		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	15	Gly-rich.|Head.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTGAAGCCCCCCTTGGCAGCA	0.617000													21	79					0	0	1	0	0
EEF1DP3	196549	broad.mit.edu	37	13	32526950	32526950	+	RNA	SNP	C	C	T	rs151166105	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32526950C>T	ENST00000428783.1	+	0	650																											ACAGCGAGCTCGTCGTCCGGA	0.637000													8	20					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107811990	107811990	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107811990G>A	ENST00000328300.6	+	6	567	c.321_splice	c.e6-1	p.G108_splice	COL4A5_ENST00000361603.2_Splice_Site_p.G108_splice	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	108	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TTTTCAAAGGGAATGCCAGGC	0.423000									Alport syndrome with Diffuse Leiomyomatosis				17	78					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92346066	92346066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:92346066G>A	ENST00000377067.3	+	3	1323	c.951G>A	c.(949-951)ctG>ctA	p.L317L		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	317						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ACGTGCTGCTGAACTTTCACT	0.453000													32	111					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39906027	39906027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39906027G>A	ENST00000425673.1	+	4	752	c.427G>A	c.(427-429)Gag>Aag	p.E143K	PLEKHG2_ENST00000409797.2_Missense_Mutation_p.E143K|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.E84K|PLEKHG2_ENST00000378550.1_Missense_Mutation_p.E143K|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.E143K			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	143	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCTGAGCGTGGAGCAGGTGGG	0.647000													22	42					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28714076	28714076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28714076G>A	ENST00000257197.3	-	13	2155	c.1894C>T	c.(1894-1896)Cgt>Tgt	p.R632C	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Missense_Mutation_p.R632C	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	632	Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TGCCGTTGACGAAGAATGGCA	0.353000													33	79					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94993217	94993217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94993217C>T	ENST00000265627.5	-	6	663	c.653G>A	c.(652-654)gGa>gAa	p.G218E	PON3_ENST00000427422.1_Missense_Mutation_p.G218E|PON1_ENST00000542556.1_Intron	NM_000940.2	NP_000931.1			paraoxonase 3									p.G218E(1)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			ACTACAAAATCCTTTGGCCAC	0.428000													81	184					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410237	105410237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105410237G>A	ENST00000333244.5	-	7	11670	c.11551C>T	c.(11551-11553)Ctc>Ttc	p.L3851F	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3851						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGAATGCTGAGGTCAGTGGTC	0.632000													84	180					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105412371	105412371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:105412371G>A	ENST00000264122.4	-	13	2342	c.2021C>T	c.(2020-2022)cCt>cTt	p.P674L	CBLB_ENST00000394027.3_Missense_Mutation_p.P696L|CBLB_ENST00000403724.1_Missense_Mutation_p.P674L|CBLB_ENST00000405772.1_Missense_Mutation_p.P674L	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	674	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						AACTGGAGGAGGAGGAGAAAG	0.413000			Mis S		AML								20	32					0	0	1	0	0
NDOR1	27158	broad.mit.edu	37	9	140109069	140109069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140109069C>T	ENST00000371521.4	+	7	853	c.770C>T	c.(769-771)gCc>gTc	p.A257V	NDOR1_ENST00000344894.5_Missense_Mutation_p.A257V|NDOR1_ENST00000427047.2_Missense_Mutation_p.A223V|NDOR1_ENST00000458322.2_Missense_Mutation_p.A257V	NM_001144026.1	NP_001137498.1	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	257	FAD-binding FR-type.				cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding			breast(1)|endometrium(5)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		AACTCGGCTGCCCATGTCCAG	0.662000													11	39					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29005439	29005439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29005439C>T	ENST00000282397.4	-	7	1073	c.822G>A	c.(820-822)aaG>aaA	p.K274K	FLT1_ENST00000539099.1_Silent_p.K274K|FLT1_ENST00000541932.1_Silent_p.K274K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	274	Ig-like C2-type 3.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CGGAAGCTCTCTTATTTTTCT	0.338000													21	41					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44449850	44449850	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:44449850G>C	ENST00000360029.3	-	1	974	c.691C>G	c.(691-693)Cgt>Ggt	p.R231G		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	231						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CGCGCCACACGCCGGAATTTG	0.711000										HNSCC(17;0.042)			5	10					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436215	248436215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248436215C>T	ENST00000318021.2	-	1	923	c.902G>A	c.(901-903)cGg>cAg	p.R301Q		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCCCAGCCACCGTTTCAGGGC	0.438000													100	207					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108863374	108863374	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:108863374G>A	ENST00000356922.4	-	2	515	c.243C>T	c.(241-243)gcC>gcT	p.A81A	LIG4_ENST00000442234.1_Silent_p.A81A|LIG4_ENST00000405925.1_Silent_p.A81A	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	81					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TAATTCCATAGGCCATTCTCT	0.353000								Non-homologous end-joining					38	125					0	0	1	0	0
PURG	29942	broad.mit.edu	37	8	30889982	30889982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30889982G>A	ENST00000475541.1	-	1	1249	c.317C>T	c.(316-318)aCc>aTc	p.T106I	PURG_ENST00000339382.2_Missense_Mutation_p.T106I	NM_013357.2	NP_037489.1	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G	106						nucleus	DNA binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CAGGGAGAGGGTCAGTTTACT	0.577000													24	61					0	0	1	0	0
PAK4	10298	broad.mit.edu	37	19	39660289	39660289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39660289C>T	ENST00000599386.1	+	3	277	c.96C>T	c.(94-96)ttC>ttT	p.F32F	PAK4_ENST00000599470.1_Silent_p.F32F|PAK4_ENST00000593690.1_Silent_p.F32F|PAK4_ENST00000360442.3_Silent_p.F32F|PAK4_ENST00000358301.3_Silent_p.F32F|PAK4_ENST00000321944.4_Silent_p.F32F|PAK4_ENST00000435673.2_Silent_p.F32F	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	32	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			AGCAGAAGTTCACGGGGCTGC	0.677000													20	61					0	0	1	0	0
TPSB2	64499	broad.mit.edu	37	16	1279691	1279691	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1279691C>T	ENST00000430512.2	-	0	160				TPSB2_ENST00000445910.1_RNA|TPSB2_ENST00000339687.6_RNA	NM_024164.5	NP_077078.5	P20231	TRYB2_HUMAN	tryptase beta 2 (gene/pseudogene)						proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			lung(1)|upper_aerodigestive_tract(1)	2		Hepatocellular(780;0.00369)				CTCCTGGGGGCCTCCTGACCC	0.701000													14	56					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26725395	26725395	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26725395C>T	ENST00000396005.3	-	5	934	c.625G>A	c.(625-627)Gga>Aga	p.G209R	SLC5A12_ENST00000280467.6_Missense_Mutation_p.G209R	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	209					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						TTGTGGAATCCCCCAGCATGA	0.398000													62	169					0	0	1	0	0
DHRS4	10901	broad.mit.edu	37	14	24424253	24424253	+	Silent	SNP	C	C	T	rs138564114	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24424253C>T	ENST00000313250.5	+	2	341	c.138C>T	c.(136-138)ttC>ttT	p.F46F	DHRS4_ENST00000543741.2_Silent_p.F46F|DHRS4_ENST00000421831.1_Silent_p.F28F|DHRS4_ENST00000397073.2_Silent_p.F28F|DHRS4_ENST00000382761.3_Silent_p.F28F|DHRS4_ENST00000308178.8_Silent_p.F28F|DHRS4_ENST00000397075.3_Silent_p.F46F|DHRS4_ENST00000558263.1_Silent_p.F46F|DHRS4_ENST00000559632.1_Silent_p.F46F|DHRS4_ENST00000397074.3_Silent_p.F46F|DHRS4_ENST00000558581.1_Silent_p.F46F	NM_021004.2	NP_066284.2	Q9BTZ2	DHRS4_HUMAN	dehydrogenase/reductase (SDR family) member 4	46						mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	GGATCGGCTTCGCCATCGCCC	0.617000													10	157					0	0	1	0	0
TTC38	55020	broad.mit.edu	37	22	46685431	46685431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46685431C>T	ENST00000381031.3	+	12	1291	c.1215C>T	c.(1213-1215)atC>atT	p.I405I	TTC38_ENST00000445282.2_Silent_p.I347I	NM_017931.2	NP_060401.2	Q5R3I4	TTC38_HUMAN	tetratricopeptide repeat domain 38	405							binding			endometrium(4)|large_intestine(3)|lung(4)|ovary(1)	12						GCTACCGGATCGTCCAGCTCG	0.721000													8	25					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22202044	22202044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:22202044C>T	ENST00000344041.6	-	13	1252	c.940G>A	c.(940-942)Gaa>Aaa	p.E314K	RAPGEF5_ENST00000401957.2_Missense_Mutation_p.E164K	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	164					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						TGTTCATCTTCAGGTAACCAG	0.343000													21	61					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20790053	20790053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20790053C>T	ENST00000359062.3	+	9	2061	c.2021C>T	c.(2020-2022)cCc>cTc	p.P674L	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	674					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ATTCTTGCTCCCGAACCTCTT	0.333000													18	36					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204289	9204289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9204289C>T	ENST00000429566.3	+	1	435	c.369C>T	c.(367-369)ttC>ttT	p.F123F		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						ATGACCGGTTCGTGGCCATCT	0.552000													30	60					0	0	1	0	0
WISP2	8839	broad.mit.edu	37	20	43355922	43355922	+	Missense_Mutation	SNP	C	C	T	rs144332553	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43355922C>T	ENST00000372868.2	+	5	1070	c.727C>T	c.(727-729)Cgc>Tgc	p.R243C	WISP2_ENST00000471629.1_3'UTR|WISP2_ENST00000372865.4_Silent_p.V160V|RP11-445H22.4_ENST00000445420.1_RNA|RP11-445H22.4_ENST00000427303.1_RNA|WISP2_ENST00000190983.4_Missense_Mutation_p.R243C|RP11-445H22.4_ENST00000427598.1_RNA			O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	243					cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CTCCAGGGGTCGCAGTCCACA	0.682000													9	32					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70672746	70672746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70672746G>A	ENST00000322773.4	+	11	1112	c.1010G>A	c.(1009-1011)gGa>gAa	p.G337E		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	337	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GGCAGCAAAGGAGAAACTGGT	0.274000													17	43					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60463381	60463381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60463381C>T	ENST00000371201.3	-	11	1487	c.1380G>A	c.(1378-1380)gtG>gtA	p.V460V	C1orf87_ENST00000450089.2_Silent_p.V231V|C1orf87_ENST00000486478.1_5'UTR|C1orf87_ENST00000395552.1_Silent_p.V94V	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	460							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CAGCTGGATTCACGAAGGGCT	0.502000													22	53					0	0	1	0	0
RABEP1	9135	broad.mit.edu	37	17	5241338	5241338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:5241338C>T	ENST00000262477.6	+	5	777	c.553C>T	c.(553-555)Cgg>Tgg	p.R185W	RABEP1_ENST00000341923.6_Missense_Mutation_p.R185W|RABEP1_ENST00000408982.2_Missense_Mutation_p.R185W|RABEP1_ENST00000546142.2_Missense_Mutation_p.R185W|RABEP1_ENST00000537505.1_Missense_Mutation_p.R142W	NM_004703.4	NP_004694.2	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	185					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	8						TGAGAAACTTCGGTCCGTTGT	0.398000													48	63					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588319	93588319	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93588319G>A	ENST00000329082.7	-	4	1533	c.1262C>T	c.(1261-1263)cCa>cTa	p.P421L	RGMA_ENST00000543599.1_Missense_Mutation_p.P405L|RGMA_ENST00000557420.1_3'UTR|RGMA_ENST00000538818.1_Missense_Mutation_p.P312L|RGMA_ENST00000425933.2_Missense_Mutation_p.P405L|RGMA_ENST00000556658.1_Missense_Mutation_p.P312L|RGMA_ENST00000557301.1_Missense_Mutation_p.P429L|RGMA_ENST00000542321.2_Missense_Mutation_p.P405L	NM_020211.2	NP_064596.2	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	421					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			CGCCCTGCCTGGCAGGTCCCG	0.647000													6	5					0	0	1	0	0
RASL11A	387496	broad.mit.edu	37	13	27847178	27847178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:27847178C>T	ENST00000241463.4	+	4	894	c.276C>T	c.(274-276)ctC>ctT	p.L92L	RASL11A_ENST00000480803.1_3'UTR	NM_206827.1	NP_996563.1	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	92	Small GTPase-like.				positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	10		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		AAGACAGCCTCCCCCAGGTCG	0.488000													25	66					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30998884	30998884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:30998884C>T	ENST00000295055.8	-	4	475	c.299G>A	c.(298-300)gGa>gAa	p.G100E	CAPN13_ENST00000534090.2_Missense_Mutation_p.G100E|CAPN13_ENST00000465960.2_5'UTR	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	100	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AGTCAAGGATCCCAGTGCTGC	0.527000													17	33					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72020966	72020966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72020966G>A	ENST00000355327.3	+	9	1570	c.1436G>A	c.(1435-1437)gGg>gAg	p.G479E	THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000357769.4_Missense_Mutation_p.G119E|THSD4_ENST00000261862.6_Missense_Mutation_p.G479E			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	479						proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GAGGGCGGAGGGACCATGTTC	0.512000													20	238					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128186496	128186496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128186496G>A	ENST00000453608.2	+	8	1533	c.1525G>A	c.(1525-1527)Gcc>Acc	p.A509T	PROC_ENST00000422777.3_Missense_Mutation_p.A454T|PROC_ENST00000234071.3_Missense_Mutation_p.A454T|PROC_ENST00000409048.1_Missense_Mutation_p.A488T			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	454					blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	AGACAAGGAAGCCCCCCAGAA	0.577000													10	115					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84188309	84188309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84188309G>A	ENST00000378553.5	+	4	604	c.480G>A	c.(478-480)atG>atA	p.M160I	DNAAF1_ENST00000334315.5_Missense_Mutation_p.M160I	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	160					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						TCTTGCAAATGAACTTGCTCC	0.463000													35	80					0	0	1	0	0
GALNT12	79695	broad.mit.edu	37	9	101585705	101585705	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101585705G>T	ENST00000375011.3	+	2	539	c.539G>T	c.(538-540)aGa>aTa	p.R180I		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	180	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.R180I(1)		breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				TACAGTGATAGAGGTGAGTCC	0.537000													12	54					0.00185496	0.00185681	1	1	0
TMEM255A	55026	broad.mit.edu	37	X	119419520	119419520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:119419520G>A	ENST00000309720.5	-	6	578	c.455C>T	c.(454-456)tCc>tTc	p.S152F	TMEM255A_ENST00000440464.1_Intron|TMEM255A_ENST00000371352.1_Intron|TMEM255A_ENST00000371369.4_Intron	NM_017938.3	NP_060408.3			transmembrane protein 255A																		AACCCTCGTGGAAGGAGAATT	0.448000													22	27					0	0	1	0	0
CPNE6	9362	broad.mit.edu	37	14	24544463	24544463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24544463G>A	ENST00000397016.2	+	9	1066	c.755G>A	c.(754-756)gGg>gAg	p.G252E	CPNE6_ENST00000537691.1_Missense_Mutation_p.G307E|CPNE6_ENST00000216775.2_Missense_Mutation_p.G252E			O95741	CPNE6_HUMAN	copine VI (neuronal)	252					lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		ATGCAGGAAGGGACGGCAAAC	0.572000													42	119					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78466040	78466040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78466040C>T	ENST00000258873.4	-	13	2189	c.1984G>A	c.(1984-1986)Gaa>Aaa	p.E662K	ACSBG1_ENST00000560817.1_Missense_Mutation_p.E420K|ACSBG1_ENST00000541759.1_Missense_Mutation_p.E420K	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	662					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						ATCCCCTCTTCGATGGCCTGG	0.582000													11	110					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22389807	22389807	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:22389807G>A	ENST00000334304.5	-	19	3756	c.3487C>T	c.(3487-3489)Cga>Tga	p.R1163*	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	1163					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				ACATTTGTTCGAAACTGAACT	0.448000													26	60					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42747236	42747236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42747236C>T	ENST00000372980.3	-	3	2069	c.1197G>A	c.(1195-1197)gaG>gaA	p.E399E		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	399	Ala-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GTTCCGCTGCCTCAGCTTTGG	0.607000													56	126					0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5331432	5331432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5331432C>T	ENST00000396872.2	+	5	685	c.524C>T	c.(523-525)aCc>aTc	p.T175I	SLC29A4_ENST00000297195.4_Missense_Mutation_p.T175I|SLC29A4_ENST00000406453.3_Missense_Mutation_p.P163S	NM_001040661.1|NM_153247.2	NP_001035751.1|NP_694979.2	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4	175					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GCTGTGGGCACCGTGGCCTTC	0.647000													11	82					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535616	27535616	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27535616G>A	ENST00000574842.1	+	0	255																											ATGGGTCTCAGAGCAGTCCAT	0.493000													48	209					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113353798	113353798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113353798G>A	ENST00000297405.5	-	42	6804	c.6560C>T	c.(6559-6561)cCa>cTa	p.P2187L	CSMD3_ENST00000352409.3_Missense_Mutation_p.P2117L|CSMD3_ENST00000343508.3_Missense_Mutation_p.P2147L|CSMD3_ENST00000455883.2_Missense_Mutation_p.P2083L	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2187	CUB 12.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TAAGGAAGATGGTATTTGAGG	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			24	70					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110495667	110495667	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:110495667G>A	ENST00000324068.1	-	5	734	c.567C>T	c.(565-567)ttC>ttT	p.F189F	CAPN6_ENST00000541758.1_Intron	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	189	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						ATGTGCCCGTGAAGTCCACAA	0.423000													32	26					0	0	1	0	0
TAS2R8	50836	broad.mit.edu	37	12	10958981	10958981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10958981G>A	ENST00000240615.2	-	1	911	c.599C>T	c.(598-600)tCa>tTa	p.S200L		NM_023918.1	NP_076407.1	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	200					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						AAGGAAAAATGATATCAGTGA	0.378000													42	66					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13717553	13717553	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13717553G>A	ENST00000265104.4	-	73	12680	c.12576C>T	c.(12574-12576)caC>caT	p.H4192H		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4192	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGACAGTGGAGTGCAGGAAAG	0.547000									Kartagener syndrome				14	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179414035	179414035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179414035C>T	ENST00000589042.1	-	339	92542	c.92318G>A	c.(92317-92319)cGa>cAa	p.R30773Q	TTN_ENST00000342992.6_Missense_Mutation_p.R28205Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R21708Q|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R21900Q|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R21833Q|RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R29132Q|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29132	Fibronectin type-III 124.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGATTGGTCGTTTGCTGAT	0.428000													30	84					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28285047	28285047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28285047G>A	ENST00000373894.3	+	8	1257	c.1066G>A	c.(1066-1068)Gag>Aag	p.E356K	SMPDL3B_ENST00000549094.1_Missense_Mutation_p.E308K|RP11-460I13.2_ENST00000448015.1_RNA	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	356					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		GCCGCGCTGGGAGCTCGAGTA	0.627000													8	76					0	0	1	0	0
CYP3A43	64816	broad.mit.edu	37	7	99459391	99459391	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99459391G>A	ENST00000354829.2	+	11	1285	c.1182G>A	c.(1180-1182)gtG>gtA	p.V394V	CYP3A43_ENST00000417625.1_Silent_p.V284V|CYP3A43_ENST00000444905.1_Silent_p.V141V|CYP3A43_ENST00000222382.5_Silent_p.V394V|CYP3A43_ENST00000415413.1_Silent_p.V183V|CYP3A43_ENST00000312017.5_Silent_p.V394V|CYP3A43_ENST00000477658.1_3'UTR|CYP3A43_ENST00000342499.4_Silent_p.V254V	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	394			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	GGTTAGCAGTGATGGTTCCAA	0.458000													40	82					0	0	1	0	0
ABCD3	5825	broad.mit.edu	37	1	94964161	94964161	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94964161C>T	ENST00000370214.4	+	17	1414	c.1390C>T	c.(1390-1392)Cga>Tga	p.R464*	ABCD3_ENST00000394233.2_Nonsense_Mutation_p.R354*|ABCD3_ENST00000536817.1_Nonsense_Mutation_p.R391*|ABCD3_ENST00000454898.2_Nonsense_Mutation_p.R488*|ABCD3_ENST00000484213.1_3'UTR	NM_002858.3	NP_002849.1	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D (ALD), member 3	464	ABC transporter.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTTTCAGGTTCGATCTGGGGC	0.338000													12	59					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159086542	159086542	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159086542C>T	ENST00000297239.9	+	4	420	c.226C>T	c.(226-228)Cgg>Tgg	p.R76W	SYTL3_ENST00000360448.3_Missense_Mutation_p.R76W|SYTL3_ENST00000367081.3_5'UTR			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	76	RabBD.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		CCTGCTGCACCGGGGCGCCGT	0.662000													8	2					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57745930	57745930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57745930G>A	ENST00000281282.5	+	7	2182	c.2104G>A	c.(2104-2106)Gat>Aat	p.D702N		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	702						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TGAGATCAGGGATCTCCAGGA	0.537000													5	27					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18768348	18768348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18768348C>T	ENST00000359846.2	-	3	289	c.212G>A	c.(211-213)gGa>gAa	p.G71E	NT5C1B_ENST00000460052.1_Intron|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.G71E|NT5C1B_ENST00000304081.4_Intron|NT5C1B_ENST00000600945.1_Missense_Mutation_p.G71E	NM_001002006.2|NM_001199086.1|NM_001199087.1|NM_001199088.1	NP_001002006.1|NP_001186015.1|NP_001186016.1|NP_001186017.1			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AAGGGCTGTTCCCTCAGCTGC	0.537000													18	34					0	0	1	0	0
TRIM60	166655	broad.mit.edu	37	4	165962504	165962504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:165962504C>T	ENST00000512596.1	+	3	1496	c.1280C>T	c.(1279-1281)tCc>tTc	p.S427F	TRIM60_ENST00000508504.1_Missense_Mutation_p.S427F|TRIM60_ENST00000341062.5_Missense_Mutation_p.S427F	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	427	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		GGTGATCTTTCCTTTTATAAT	0.378000													36	81					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5036231	5036231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:5036231G>A	ENST00000574788.1	+	13	2452	c.222G>A	c.(220-222)acG>acA	p.T74T	USP6_ENST00000572429.1_3'UTR|USP6_ENST00000332776.4_Silent_p.T74T|USP6_ENST00000304328.5_5'UTR|USP6_ENST00000250066.6_Silent_p.T74T			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	74					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TGACACGAACGAGCAAGTGGA	0.527000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								19	179					0	0	1	0	0
CCNB1IP1	57820	broad.mit.edu	37	14	20781668	20781668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20781668G>A	ENST00000398169.3	-	6	1206	c.590C>T	c.(589-591)cCa>cTa	p.P197L	CCNB1IP1_ENST00000358932.4_Missense_Mutation_p.P197L|CCNB1IP1_ENST00000353689.4_Missense_Mutation_p.P197L|CCNB1IP1_ENST00000437553.2_Missense_Mutation_p.P197L|CCNB1IP1_ENST00000398160.2_Missense_Mutation_p.P197L|CCNB1IP1_ENST00000398163.2_Missense_Mutation_p.P197L			Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1, E3 ubiquitin protein ligase	197						chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	9	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		AATCATGGATGGTTCAAGGGT	0.418000			T	HMGA2	leiomyoma								27	115					0	0	1	0	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959264	45959264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45959264G>A	ENST00000400375.1	-	1	814	c.770C>T	c.(769-771)tCc>tTc	p.S257F	TSPEAR_ENST00000323084.4_Intron|TSPEAR_ENST00000397916.1_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	257	24 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						GGCCTGGCAGGAGGAGGCAGG	0.726000													18	50					0	0	1	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6374257	6374257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6374257C>T	ENST00000335585.5	-	5	641	c.618G>A	c.(616-618)agG>agA	p.R206R	PPP2R2C_ENST00000507294.1_Silent_p.R199R|PPP2R2C_ENST00000515571.1_Silent_p.R189R|PPP2R2C_ENST00000314348.8_5'UTR|PPP2R2C_ENST00000382599.4_Silent_p.R206R|PPP2R2C_ENST00000506140.1_Silent_p.R199R	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	206					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						TACTGAAGCTCCTGTCGGTGA	0.577000													27	57					0	0	1	0	0
PARPBP	55010	broad.mit.edu	37	12	102569432	102569432	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102569432C>T	ENST00000327680.2	+	8	1213	c.750C>T	c.(748-750)atC>atT	p.I250I	PARPBP_ENST00000358383.5_Silent_p.I331I|PARPBP_ENST00000392911.2_Silent_p.I250I|PARPBP_ENST00000535811.1_Intron|PARPBP_ENST00000543784.1_Intron|PARPBP_ENST00000541394.1_Silent_p.I408I|PARPBP_ENST00000378128.3_Intron	NM_017915.3	NP_060385.3	Q9NWS1	PR1BP_HUMAN	PARP1 binding protein	331					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding			endometrium(1)|lung(8)|urinary_tract(2)	11						CCACTGACATCAGTCCTGCTC	0.318000													18	41					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123508947	123508947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123508947C>T	ENST00000392770.2	-	4	1333	c.531G>A	c.(529-531)atG>atA	p.M177I	SCN3B_ENST00000530277.1_Missense_Mutation_p.M177I|SCN3B_ENST00000299333.3_Missense_Mutation_p.M177I	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	177					axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		AGCAATATATCATCTCGATGA	0.453000													15	57					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4832520	4832520	+	Silent	SNP	C	C	T	rs151154079		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:4832520C>T	ENST00000378191.4	+	4	1479	c.1098C>T	c.(1096-1098)ccC>ccT	p.P366P	AJAP1_ENST00000378190.3_Silent_p.P366P	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	366	Targeting signals.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CATCTGTGCCCGTGTACACCG	0.592000													15	28					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5941682	5941682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5941682G>A	ENST00000356134.5	-	6	783	c.712C>T	c.(712-714)Cca>Tca	p.P238S	ANO2_ENST00000327087.8_Missense_Mutation_p.P237S|ANO2_ENST00000546188.1_Missense_Mutation_p.P238S	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	242						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CTGTGTTCTGGAACTCGGGGC	0.507000													20	50					0	0	1	0	0
ABCG2	9429	broad.mit.edu	37	4	89036161	89036161	+	Silent	SNP	G	G	A	rs144639395		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89036161G>A	ENST00000237612.3	-	8	1436	c.891C>T	c.(889-891)atC>atT	p.I297I	ABCG2_ENST00000515655.1_Silent_p.I297I	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	297					cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	CTCCATTAATGATGTCCAAGA	0.383000													13	63					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79341864	79341864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79341864C>T	ENST00000419573.3	-	4	872	c.598G>A	c.(598-600)Gac>Aac	p.D200N	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.D200N	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	200					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ATGTCGCTGTCTTCATCGTTG	0.547000													15	65					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47569694	47569694	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47569694G>A	ENST00000253048.5	-	15	3868	c.3831C>T	c.(3829-3831)gcC>gcT	p.A1277A	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1277							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CACCCTCGCGGGCCGGACTGT	0.637000													5	1					0	0	1	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44420688	44420688	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44420688G>A	ENST00000372622.3	+	1	113	c.45G>A	c.(43-45)ggG>ggA	p.G15G		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	15						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				GACCTAGCGGGGCCGAGAGGG	0.751000													6	11					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11700964	11700964	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11700964C>T	ENST00000262442.3	+	43	8342	c.8274C>T	c.(8272-8274)caC>caT	p.H2758H	DNAH9_ENST00000454412.2_Silent_p.H2758H	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2758					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGTATTGTCACTTTGCAAATG	0.493000													17	32					0	0	1	0	0
PRSS55	203074	broad.mit.edu	37	8	10387029	10387029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10387029G>A	ENST00000328655.3	+	2	207	c.167G>A	c.(166-168)aGa>aAa	p.R56K	PRSS51_ENST00000523024.1_RNA|PRSS55_ENST00000522210.1_Missense_Mutation_p.R56K	NM_198464.3	NP_940866.2	Q6UWB4	PRS55_HUMAN	protease, serine, 55	56					proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						TGTGGTGACAGATCTATTTTC	0.532000													42	124					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40677882	40677882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40677882C>T	ENST00000298910.7	+	19	2505	c.2447C>T	c.(2446-2448)tCt>tTt	p.S816F	LRRK2_ENST00000343742.2_Missense_Mutation_p.S816F	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	816					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTTGAACCTTCTTGGCTTGGT	0.368000													10	97					0	0	1	0	0
KDM7A	80853	broad.mit.edu	37	7	139826473	139826473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139826473G>A	ENST00000397560.2	-	6	949	c.852C>T	c.(850-852)gaC>gaT	p.D284D	JHDM1D_ENST00000006967.5_Silent_p.D284D	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		284	JmjC.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					TTCCACCGAAGTCAATGTGGA	0.398000													53	113					0	0	1	0	0
C16orf90	646174	broad.mit.edu	37	16	3544772	3544772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3544772C>T	ENST00000437192.3	-	2	154	c.152G>A	c.(151-153)gGa>gAa	p.G51E	LA16c-306E5.3_ENST00000574423.2_RNA	NM_001080524.1	NP_001073993.1	A8MZG2	CP090_HUMAN	chromosome 16 open reading frame 90	41										large_intestine(1)	1						GGGCTTGCTTCCCTGGGCACT	0.716000													7	10					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439455	150439455	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150439455G>A	ENST00000358647.3	+	3	595	c.228G>A	c.(226-228)agG>agA	p.R76R	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAACGGGAGGAAAGTCCTGG	0.582000													28	48					0	0	1	0	0
TRBV10-1	28585	broad.mit.edu	37	7	142232051	142232051	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142232051C>T	ENST00000390364.3	-	0	39																											TCTTGTGTCTCCCAGCCCTGC	0.577000													7	35					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541145	40541145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40541145G>A	ENST00000434248.1	-	5	1686	c.1621C>T	c.(1621-1623)Cac>Tac	p.H541Y	ZNF780B_ENST00000221355.6_Missense_Mutation_p.H393Y	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	541					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGTTGTAGGTGAAGTCTAAAA	0.418000													13	106					0	0	1	0	0
LSM14A	26065	broad.mit.edu	37	19	34699853	34699853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:34699853C>T	ENST00000544216.3	+	4	512	c.435C>T	c.(433-435)tcC>tcT	p.S145S	LSM14A_ENST00000433627.5_Silent_p.S145S|LSM14A_ENST00000540746.2_Intron	NM_015578.2	NP_056393.2	Q8ND56	LS14A_HUMAN	LSM14A, SCD6 homolog A (S. cerevisiae)	145					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					CTTTGACATCCTTTGGAACAG	0.328000													8	27					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51287566	51287566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:51287566G>A	ENST00000395542.2	-	2	301	c.117C>T	c.(115-117)ccC>ccT	p.P39P	COBL_ENST00000395540.2_Silent_p.P39P|COBL_ENST00000441453.1_Silent_p.P39P|COBL_ENST00000265136.7_Silent_p.P39P			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	39										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CATCGTGGGGGGGCTTCTGGT	0.607000													25	58					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40392512	40392512	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40392512G>A	ENST00000221347.6	-	16	7999	c.7992C>T	c.(7990-7992)ctC>ctT	p.L2664L		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2664	VWFD 6.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCTGGAGAGGAGCCCACAGA	0.627000													10	89					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38406338	38406338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38406338G>A	ENST00000322350.5	+	7	1169	c.823G>A	c.(823-825)Gag>Aag	p.E275K	EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000336740.6_Missense_Mutation_p.E41K|EGFLAM_ENST00000354891.3_Missense_Mutation_p.E275K	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	275						cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TATTTCCTTTGAGGAGGTAAC	0.428000													12	33					0	0	1	0	0
C8orf74	203076	broad.mit.edu	37	8	10555134	10555134	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10555134G>A	ENST00000304519.5	+	3	296	c.267G>A	c.(265-267)acG>acA	p.T89T	RP1L1_ENST00000329335.3_Intron	NM_001040032.1	NP_001035121.1	Q6P047	CH074_HUMAN	chromosome 8 open reading frame 74	89										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	13				COAD - Colon adenocarcinoma(149;0.0811)		AGGCTGTGACGATCCTGGGGA	0.587000													12	142					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203029380	203029380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203029380C>T	ENST00000367240.2	+	21	3083	c.2556C>T	c.(2554-2556)gcC>gcT	p.A852A	PPFIA4_ENST00000447715.2_Silent_p.A851A|PPFIA4_ENST00000272198.6_Silent_p.A367A|PPFIA4_ENST00000295706.4_Silent_p.A367A|PPFIA4_ENST00000414050.2_Silent_p.A580A|PPFIA4_ENST00000599966.1_Silent_p.A367A			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	367					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						ATGTGGCAGCCTGCCGGGCCA	0.617000													14	41					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872836	55872836	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55872836C>T	ENST00000313503.1	+	1	318	c.318C>T	c.(316-318)ttC>ttT	p.F106F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TTTTTGCCTTCTTGGGTACTG	0.448000										HNSCC(53;0.14)			146	370					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870920	13870920	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13870920T>G	ENST00000265104.4	-	24	3894	c.3790A>C	c.(3790-3792)Agg>Cgg	p.R1264R	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1264	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGCTCCTCCCTTATTTCTTTC	0.328000									Kartagener syndrome				16	57					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140397412	140397412	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140397412C>T	ENST00000286349.3	+	1	532	c.341_splice	c.e1+1	p.S114_splice		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	114						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ATCCATACCTCGTAAGTGCCA	0.562000													8	18					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113352918	113352918	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113352918C>T	ENST00000458497.1	+	11	2494	c.2215C>T	c.(2215-2217)Caa>Taa	p.Q739*	ALPK1_ENST00000177648.9_Nonsense_Mutation_p.Q739*|ALPK1_ENST00000504176.2_Nonsense_Mutation_p.Q661*	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	739							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TCCTTCAGTCCAAAAAGAAGA	0.443000													37	64					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38565541	38565541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38565541C>T	ENST00000287675.5	+	6	891	c.795C>T	c.(793-795)ttC>ttT	p.F265F	EXOG_ENST00000422077.2_Silent_p.F215F|EXOG_ENST00000358249.2_Intron	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	265						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						TAACTGAATTCCAAGTGAGCC	0.512000													24	111					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90049587	90049587	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90049587C>A	ENST00000405460.2	+	54	11414	c.11318C>A	c.(11317-11319)cCt>cAt	p.P3773H		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3773					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATGACTCACCTTTTGGCTTG	0.428000													5	26					0.000602214	0.000602938	1	1	0
PCDH18	54510	broad.mit.edu	37	4	138452406	138452406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138452406C>T	ENST00000344876.4	-	1	1223	c.837G>A	c.(835-837)ggG>ggA	p.G279G	PCDH18_ENST00000412923.2_Silent_p.G279G|PCDH18_ENST00000507846.1_Silent_p.G59G|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	279	Cadherin 3.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ATACAATTTTCCCATTAGCGC	0.398000													27	79					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92564840	92564840	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92564840C>T	ENST00000298047.6	+	13	9551	c.9534C>T	c.(9532-9534)ttC>ttT	p.F3178F	FAT3_ENST00000409404.2_Silent_p.F3178F|FAT3_ENST00000525166.1_Silent_p.F3028F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3178	Cadherin 29.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGGGTCTTCTCCATTGACA	0.557000										TCGA Ovarian(4;0.039)			4	29					0	0	1	0	0
SELL	6402	broad.mit.edu	37	1	169677869	169677869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169677869C>T	ENST00000236147.4	-	3	360	c.200G>A	c.(199-201)aGa>aAa	p.R67K	C1orf112_ENST00000498289.1_Intron|SELL_ENST00000463108.1_5'UTR	NM_000655.4	NP_000646.2	P14151	LYAM1_HUMAN	selectin L	54	C-type lectin.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	15	all_hematologic(923;0.208)					GCAGAATCTTCTAGCCCTTTG	0.438000													9	15					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11651035	11651035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11651035G>A	ENST00000262442.3	+	32	6630	c.6562G>A	c.(6562-6564)Gat>Aat	p.D2188N	DNAH9_ENST00000454412.2_Missense_Mutation_p.D2188N	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2188	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGTCACAAATGATGAGCTCTT	0.522000													21	38					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108380669	108380669	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108380669G>A	ENST00000265843.4	-	6	5675	c.5565C>T	c.(5563-5565)ctC>ctT	p.L1855L	EXPH5_ENST00000428840.1_Silent_p.L1779L|EXPH5_ENST00000443411.1_Silent_p.L1667L|EXPH5_ENST00000525344.1_Silent_p.L1848L	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1855					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CACAGGAGGGGAGTTCAGAAA	0.448000													15	56					0	0	1	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77317640	77317640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77317640C>T	ENST00000558012.1	+	4	717	c.228C>T	c.(226-228)tcC>tcT	p.S76S	PSTPIP1_ENST00000267939.5_Silent_p.S75S|PSTPIP1_ENST00000559295.1_Silent_p.S76S|PSTPIP1_ENST00000379595.3_Silent_p.S76S	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	76	FCH.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						TGAGGGCCTCCTTTGACTCCT	0.617000													31	98					0	0	1	0	0
ZNF214	7761	broad.mit.edu	37	11	7022292	7022292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7022292C>T	ENST00000278314.4	-	3	937	c.622G>A	c.(622-624)Gac>Aac	p.D208N	ZNF214_ENST00000536068.1_Missense_Mutation_p.D208N	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		CTCAGTAGGTCTTCTTGACAT	0.388000													19	85					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61028342	61028342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61028342C>T	ENST00000373867.3	-	9	1129	c.664G>A	c.(664-666)Gaa>Aaa	p.E222K	FAM13C_ENST00000277705.6_Missense_Mutation_p.E326K|FAM13C_ENST00000419214.2_Missense_Mutation_p.E305K|FAM13C_ENST00000435852.2_Missense_Mutation_p.E305K|FAM13C_ENST00000422313.2_Missense_Mutation_p.E305K|FAM13C_ENST00000468840.2_Missense_Mutation_p.E222K|FAM13C_ENST00000373868.2_Missense_Mutation_p.E305K|FAM13C_ENST00000442566.3_Missense_Mutation_p.E326K	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	305										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TCAAATTTTTCTTCAAATTTC	0.493000													19	55					0	0	1	0	0
VWA1	64856	broad.mit.edu	37	1	1374575	1374575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1374575C>T	ENST00000476993.1	+	3	824	c.746C>T	c.(745-747)cCc>cTc	p.P249L	VWA1_ENST00000338660.5_3'UTR|VWA1_ENST00000404702.3_Missense_Mutation_p.P37L	NM_022834.4	NP_073745.2	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	249	Fibronectin type-III 1.					basement membrane				NS(1)|breast(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GAGCTGGTGCCCAGCGCCCAG	0.701000													3	25					0	0	1	0	0
WDR27	253769	broad.mit.edu	37	6	170068224	170068224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:170068224G>A	ENST00000333572.6	-	5	1033	c.514C>T	c.(514-516)Cca>Tca	p.P172S	WDR27_ENST00000423258.1_Intron|WDR27_ENST00000420344.2_Intron|WDR27_ENST00000448612.1_Missense_Mutation_p.P172S			A2RRH5	WDR27_HUMAN	WD repeat domain 27	152										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GTCGGTGGTGGGACTTTGTGG	0.517000													22	29					0	0	1	0	0
SP7	121340	broad.mit.edu	37	12	53723042	53723042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53723042C>T	ENST00000536324.2	-	3	467	c.184G>A	c.(184-186)Gat>Aat	p.D62N	SP7_ENST00000537210.2_Missense_Mutation_p.D44N|SP7_ENST00000303846.3_Missense_Mutation_p.D62N	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	62					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						GGATAAGCATCCCCCATGGTT	0.552000													44	139					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42510865	42510865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42510865C>T	ENST00000262895.3	-	15	1968	c.1969G>A	c.(1969-1971)Gac>Aac	p.D657N	GRIK5_ENST00000593562.1_Missense_Mutation_p.D657N|GRIK5_ENST00000301218.4_Missense_Mutation_p.D657N	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	657						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TCTGCCAGGTCATCGGCCGAC	0.617000													11	36					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230425	140230425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140230425C>T	ENST00000378122.3	+	1	3069	c.2345C>T	c.(2344-2346)tCt>tTt	p.S782F	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.S782F|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCTGGATCTACAGAGCGA	0.488000													45	42					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101348213	101348213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101348213G>A	ENST00000534062.1	-	1	2971	c.2913C>T	c.(2911-2913)gtC>gtT	p.V971V		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	971										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						AGAAGAAGAAGACCCAATGCC	0.552000													34	134					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8610561	8610561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8610561G>A	ENST00000338257.8	-	13	1596	c.1329C>T	c.(1327-1329)gtC>gtT	p.V443V		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	443	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GGTCACAGACGACCTTGTTGT	0.572000													71	321					0	0	1	0	0
MSANTD2	79684	broad.mit.edu	37	11	124637184	124637184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124637184G>A	ENST00000526629.1	-	3	2325	c.878C>T	c.(877-879)cCc>cTc	p.P293L	MSANTD2_ENST00000239614.4_Missense_Mutation_p.P471L|MSANTD2_ENST00000374979.3_Missense_Mutation_p.P523L			Q6P1R3	CK061_HUMAN	Myb/SANT-like DNA-binding domain containing 2	523																	GATGGATTTGGGGGAAACTCC	0.408000													45	105					0	0	1	0	0
DMC1	11144	broad.mit.edu	37	22	38962607	38962607	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38962607C>T	ENST00000216024.2	-	4	507	c.231G>A	c.(229-231)gcG>gcA	p.A77A	DMC1_ENST00000428462.2_Silent_p.A77A	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	77					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					TTAGTTTGTTCGCTGCCTCTT	0.378000								Homologous recombination					17	51					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107041010	107041010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107041010G>A	ENST00000409886.3	-	20	3500	c.3413C>T	c.(3412-3414)tCt>tTt	p.S1138F	RGPD3_ENST00000304514.7_Missense_Mutation_p.S1138F	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1138	RanBD1 1.				intracellular transport		binding	p.S1138Y(2)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						ATCACCATCAGAGAAATCACT	0.448000													84	127					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41327598	41327598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41327598G>A	ENST00000551295.2	+	9	1020	c.903G>A	c.(901-903)caG>caA	p.Q301Q	CNTN1_ENST00000360099.3_Silent_p.Q301Q|CNTN1_ENST00000547702.1_Silent_p.Q301Q|CNTN1_ENST00000347616.1_Silent_p.Q301Q|CNTN1_ENST00000348761.2_Silent_p.Q290Q|CNTN1_ENST00000547849.1_Silent_p.Q301Q	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	301	Ig-like C2-type 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TCAATATTCAGCTAGAAGATG	0.408000													19	68					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34487474	34487474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34487474C>T	ENST00000374012.3	+	10	1594	c.1465C>T	c.(1465-1467)Ccg>Tcg	p.P489S	PHF20_ENST00000481202.1_3'UTR|PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					AGAAGAGAGCCCGGGAAAGAG	0.512000													19	56					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32376538	32376538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32376538C>T	ENST00000298386.2	+	18	2332	c.2261C>T	c.(2260-2262)tCc>tTc	p.S754F	RXFP2_ENST00000380314.1_Missense_Mutation_p.S730F	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	754						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		AAACCAGTTTCCTAGCAATCA	0.403000													88	204					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27690811	27690811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27690811G>A	ENST00000493901.1	-	5	818	c.579C>T	c.(577-579)ggC>ggT	p.G193G	MAP3K6_ENST00000357582.2_Silent_p.G193G|MAP3K6_ENST00000374040.3_Silent_p.G185G	NM_004672.3	NP_004663.3	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	193					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CCCGCAGAAGGCCTGCATCAC	0.662000													33	94					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52382951	52382951	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52382951C>T	ENST00000420323.2	+	13	2415	c.2154C>T	c.(2152-2154)tcC>tcT	p.S718S		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	718	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGCTGGAGTCCGTGGGCCTTC	0.617000													37	96					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89156784	89156784	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89156784G>A	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA|IGKC_ENST00000390237.2_RNA																							ACCGCAATAGGGGTAGGTCCC	0.522000													4	14					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248437015	248437015	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248437015C>T	ENST00000318021.2	-	1	123	c.102G>A	c.(100-102)ttG>ttA	p.L34L		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACAGGGAGGTCAAAACGATAC	0.493000													24	90					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481976	123481976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123481976G>A	ENST00000280562.5	-	10	1573	c.1368C>T	c.(1366-1368)ttC>ttT	p.F456F	PITPNM2_ENST00000320201.4_Silent_p.F456F|PITPNM2_ENST00000392428.1_Silent_p.F177F|PITPNM2_ENST00000542749.1_Silent_p.F456F			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	456					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGACGGTGTCGAACACGTTGG	0.672000													33	86					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118629401	118629401	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:118629401G>A	ENST00000336338.5	-	12	1569	c.1504C>T	c.(1504-1506)Cat>Tat	p.H502Y		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	502						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AATATGTCATGAAGATTCTAT	0.388000													35	88					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30971164	30971164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:30971164C>T	ENST00000399914.1	-	8	1713	c.1192G>A	c.(1192-1194)Gaa>Aaa	p.E398K	GRIK1_ENST00000389125.3_Missense_Mutation_p.E398K|GRIK1_ENST00000309434.7_Missense_Mutation_p.E400K|GRIK1_ENST00000327783.4_Missense_Mutation_p.E398K|GRIK1_ENST00000535441.1_Missense_Mutation_p.E400K|GRIK1_ENST00000389124.2_Missense_Mutation_p.E398K|GRIK1_ENST00000399907.1_Missense_Mutation_p.E398K|GRIK1_ENST00000399909.1_Missense_Mutation_p.E398K|GRIK1_ENST00000472429.1_5'UTR|GRIK1-AS2_ENST00000333765.4_Intron|BACH1_ENST00000462262.1_Intron|GRIK1_ENST00000399913.1_Missense_Mutation_p.E398K			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	398					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TCAGTTCCTTCCTCTTTGAGA	0.368000													32	84					0	0	1	0	0
SCN2B	6327	broad.mit.edu	37	11	118037788	118037788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118037788C>T	ENST00000278947.5	-	4	703	c.462G>A	c.(460-462)cgG>cgA	p.R154R		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	154	Ig-like C2-type.				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		CCGTGGAGTCCCGCTCAGGGG	0.617000													21	48					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10554890	10554890	+	Silent	SNP	G	G	A	rs148322984		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10554890G>A	ENST00000583535.1	-	5	531	c.444C>T	c.(442-444)cgC>cgT	p.R148R	MYH3_ENST00000226209.7_Silent_p.R148R	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	148	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GGGCCTCCTGGCGCTTTTTGC	0.577000													95	113					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8807901	8807901	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8807901C>T	ENST00000324436.3	-	1	1271	c.1151G>A	c.(1150-1152)gGc>gAc	p.G384D		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	384						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						CAGGATGGAGCCCCCGATCCA	0.647000													14	44					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111962889	111962889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111962889G>A	ENST00000305815.5	-	11	1484	c.1232C>T	c.(1231-1233)aCc>aTc	p.T411I	SLC9C1_ENST00000487372.1_Missense_Mutation_p.T363I	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	411					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										GACAACAAGGGTTATTAGGCA	0.308000													18	65					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60637186	60637186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60637186C>T	ENST00000278853.5	+	3	495	c.495C>T	c.(493-495)ctC>ctT	p.L165L		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	165					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						TTTCCTTCCTCCCCACCTCTG	0.617000													16	33					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79059007	79059007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79059007C>T	ENST00000388820.4	-	19	3456	c.3246G>A	c.(3244-3246)gaG>gaA	p.E1082E		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1082					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GATCGGGCTCCTCAGAGGGCC	0.632000													7	51					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94740655	94740655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94740655G>A	ENST00000289495.5	+	2	1696	c.1480G>A	c.(1480-1482)Gaa>Aaa	p.E494K	PPP1R9A_ENST00000340694.4_Missense_Mutation_p.E494K|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.E494K|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.E494K|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.E494K|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.E494K	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	494	Interacts with protein phosphatase 1 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GTATGAACTTGAAAAACGTGT	0.403000										HNSCC(28;0.073)			18	45					0	0	1	0	0
ZNF384	171017	broad.mit.edu	37	12	6781694	6781694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6781694G>A	ENST00000396801.3	-	8	1123	c.916C>T	c.(916-918)Cac>Tac	p.H306Y	ZNF384_ENST00000396795.1_Intron|ZNF384_ENST00000355772.4_Intron|ZNF384_ENST00000396799.2_Intron|ZNF384_ENST00000361959.3_Missense_Mutation_p.H306Y|ZNF384_ENST00000319770.3_Intron	NM_001135734.2	NP_001129206.1	Q8TF68	ZN384_HUMAN	zinc finger protein 384	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						ATCTTGGAGTGGATCCTGCCG	0.607000			T	"""EWSR1, TAF15 """	ALL								14	31					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31864570	31864570	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31864570G>A	ENST00000396184.3	-	14	1521	c.1317C>T	c.(1315-1317)ttC>ttT	p.F439F	PDE1C_ENST00000396182.2_Silent_p.F439F|PDE1C_ENST00000396191.1_Silent_p.F439F|PDE1C_ENST00000321453.7_Silent_p.F439F|PDE1C_ENST00000396193.1_Silent_p.F499F	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	439	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			TAAGCACAGTGAAGGTGGGTT	0.473000													49	95					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157514069	157514069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157514069G>A	ENST00000361835.3	-	5	984	c.827C>T	c.(826-828)tCc>tTc	p.S276F	FCRL5_ENST00000356953.4_Missense_Mutation_p.S276F|FCRL5_ENST00000368190.3_Missense_Mutation_p.S276F|FCRL5_ENST00000368189.3_Missense_Mutation_p.S276F|FCRL5_ENST00000368191.3_Missense_Mutation_p.S191F	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	276						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CTGTATCCAGGATCTCGGGCT	0.507000													26	155					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128342409	128342409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128342409C>T	ENST00000389524.4	+	14	1664	c.1611C>T	c.(1609-1611)gcC>gcT	p.A537A	MYO7B_ENST00000428314.1_Silent_p.A537A|MYO7B_ENST00000409816.2_Silent_p.A537A			Q6PIF6	MYO7B_HUMAN	myosin VIIB	537	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACAACAAGGCCTTCCTACAGC	0.557000													23	110					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50090851	50090851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50090851C>T	ENST00000281631.5	+	12	1186	c.1028C>T	c.(1027-1029)tCc>tTc	p.S343F	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505697.2_Missense_Mutation_p.S343F|PARP8_ENST00000503750.2_Missense_Mutation_p.S343F|PARP8_ENST00000505554.1_Missense_Mutation_p.S322F|PARP8_ENST00000514067.2_Missense_Mutation_p.S343F|PARP8_ENST00000514342.2_Missense_Mutation_p.S96F	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	343						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				TTTGGCCGCTCCTTGTCCAGC	0.517000													29	85					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8417209	8417209	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8417209G>A	ENST00000360416.3	-	22	2646	c.2508C>T	c.(2506-2508)gcC>gcT	p.A836A	MYH10_ENST00000379980.4_Silent_p.A821A|MYH10_ENST00000396239.1_Silent_p.A826A|MYH10_ENST00000269243.4_Silent_p.A805A	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	805					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TCTTGGCAAAGGCCCTGAAGA	0.453000													5	12					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65325929	65325929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:65325929G>A	ENST00000342505.4	-	9	1441	c.1193C>T	c.(1192-1194)tCc>tTc	p.S398F		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	398	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		CTCCTCGTGGGAAGAGAGCTT	0.542000			Mis		ALL								18	52					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6055729	6055729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6055729G>A	ENST00000282924.5	-	13	2339	c.1854C>T	c.(1852-1854)ctC>ctT	p.L618L	JAKMIP1_ENST00000409021.3_Intron|JAKMIP1_ENST00000410077.2_Silent_p.L453L|JAKMIP1_ENST00000409831.1_Silent_p.L618L|JAKMIP1_ENST00000409371.3_Intron	NM_144720.3	NP_653321.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	618	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TGGGTTCAAAGAGAATGTCTG	0.373000													44	147					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92532058	92532058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92532058G>A	ENST00000298047.6	+	9	5896	c.5879G>A	c.(5878-5880)gGa>gAa	p.G1960E	FAT3_ENST00000409404.2_Missense_Mutation_p.G1960E|FAT3_ENST00000525166.1_Missense_Mutation_p.G1810E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1960	Cadherin 17.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGTCTGATGGAAAGTTCTAC	0.413000										TCGA Ovarian(4;0.039)			45	79					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2983188	2983188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2983188G>A	ENST00000342628.2	-	2	570	c.457C>T	c.(457-459)Cct>Tct	p.P153S	FOXM1_ENST00000361953.3_Missense_Mutation_p.P153S|FOXM1_ENST00000537018.1_5'UTR|FOXM1_ENST00000359843.3_Missense_Mutation_p.P153S	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	153					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GGTGGTCTAGGAAGATTCACA	0.557000													16	123					0	0	1	0	0
RAC2	5880	broad.mit.edu	37	22	37627425	37627425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37627425G>A	ENST00000249071.6	-	5	415	c.294C>T	c.(292-294)ttC>ttT	p.F98F	RAC2_ENST00000406508.1_Silent_p.F54F|RAC2_ENST00000405484.1_Silent_p.F91F	NM_002872.3	NP_002863.1	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	98					axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)	12						GCACTTCTGGGAACCACTGGG	0.627000													21	51					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89346988	89346988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89346988G>A	ENST00000301030.4	-	9	6422	c.5962C>T	c.(5962-5964)Ccc>Tcc	p.P1988S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1988S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1988	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGGGACTCGGGGAATCTCTGT	0.692000													5	57					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064667	9064667	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9064667G>A	ENST00000397910.4	-	3	22982	c.22779C>T	c.(22777-22779)tcC>tcT	p.S7593S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7595	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGACATTGTGGACTGCTCAG	0.488000													35	80					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232561550	232561550	+	Missense_Mutation	SNP	G	G	A	rs150962063		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:232561550G>A	ENST00000366630.1	-	17	4773	c.4415C>T	c.(4414-4416)tCg>tTg	p.S1472L	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.S1472L|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.S546L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1472					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity	p.S1472L(1)		NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCCATAGAACGAAAACTAGGG	0.507000													7	26					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116429583	116429583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:116429583G>A	ENST00000281928.3	-	17	3382	c.3176C>T	c.(3175-3177)aCt>aTt	p.T1059I		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1059					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		ACCTCTGGGAGTTCTTGGGGT	0.612000													24	75					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43623872	43623872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43623872C>T	ENST00000372806.3	+	6	762	c.667C>T	c.(667-669)Cct>Tct	p.P223S	STK4_ENST00000396731.4_Missense_Mutation_p.P223S|STK4_ENST00000372801.1_Missense_Mutation_p.P223S|STK4_ENST00000499879.2_Missense_Mutation_p.P168S	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	223	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				AGGAAAGCCCCCTTATGCTGA	0.448000													22	68					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9391729	9391729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9391729C>T	ENST00000378501.2	+	21	2024	c.2009C>T	c.(2008-2010)tCg>tTg	p.S670L	PLCB4_ENST00000414679.2_Missense_Mutation_p.S682L|PLCB4_ENST00000378493.1_Missense_Mutation_p.S670L|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.S670L|PLCB4_ENST00000378473.3_Missense_Mutation_p.S682L|PLCB4_ENST00000334005.3_Missense_Mutation_p.S670L	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	670	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity	p.S670L(1)		NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TATAATGGATCGTGCGGGTGA	0.363000													33	58					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349739	100349739	+	RNA	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100349739T>A	ENST00000542585.1	+	0	2159				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GACCACCACCTCCATGGAAGA	0.522000													25	68					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20387405	20387405	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20387405G>A	ENST00000302451.4	-	4	776	c.528C>T	c.(526-528)atC>atT	p.I176I		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	176					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						AGAAGCCAACGATGACCAAGG	0.522000													15	45					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67691229	67691229	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:67691229C>T	ENST00000545606.1	+	5	971	c.534C>T	c.(532-534)acC>acT	p.T178T		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	178					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		CAATTCTGACCTGTCTACTTC	0.393000													74	176					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73447448	73447448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73447448C>T	ENST00000224721.6	+	18	2051	c.2046C>T	c.(2044-2046)ttC>ttT	p.F682F	CDH23_ENST00000299366.7_Silent_p.F722F	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	677	Cadherin 7.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CCGCCTACTTCGTCTCCGTGG	0.627000													21	17					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3155824	3155824	+	Silent	SNP	C	C	T	rs140382547		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3155824C>T	ENST00000262958.3	+	5	876	c.618C>T	c.(616-618)atC>atT	p.I206I		NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	206					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		CCTGTAGGATCGTGGACGTCG	0.557000													19	46					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857197	9857197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9857197G>A	ENST00000396573.2	-	14	4513	c.4204C>T	c.(4204-4206)Cgg>Tgg	p.R1402W	GRIN2A_ENST00000404927.2_3'UTR|GRIN2A_ENST00000562109.1_3'UTR|GRIN2A_ENST00000330684.3_Missense_Mutation_p.R1402W|GRIN2A_ENST00000396575.2_Missense_Mutation_p.R1402W|GRIN2A_ENST00000535259.1_3'UTR	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1402					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.R1402W(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAGGACGACCGAAGATAGCTG	0.522000													17	65					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112758801	112758801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:112758801C>T	ENST00000295408.4	+	11	1885	c.1628C>T	c.(1627-1629)tCt>tTt	p.S543F	MERTK_ENST00000421804.2_Missense_Mutation_p.S543F|MERTK_ENST00000409780.1_Missense_Mutation_p.S367F			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	543					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						GAGGAGGATTCTGAATTAGTG	0.403000													33	51					0	0	1	0	0
PSMD4	5710	broad.mit.edu	37	1	151238796	151238796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151238796C>T	ENST00000368884.3	+	8	856	c.776C>T	c.(775-777)gCc>gTc	p.A259V	PSMD4_ENST00000368881.4_Missense_Mutation_p.A262V	NM_002810.2	NP_002801.1	P55036	PSMD4_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	259					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|lung(7)	11	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCAGACGATGCCCTGCTGAAG	0.547000													54	133					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7531715	7531715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7531715G>A	ENST00000313599.3	-	9	2287	c.2230C>T	c.(2230-2232)Cat>Tat	p.H744Y	CD163L1_ENST00000416109.2_Missense_Mutation_p.H754Y|CD163L1_ENST00000396630.1_Missense_Mutation_p.H744Y|CD163L1_ENST00000544331.1_Intron			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	744	SRCR 7.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TCTGTGAAATGAGGCTCTCTG	0.478000													29	121					0	0	1	0	0
KCNK15	60598	broad.mit.edu	37	20	43378995	43378995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43378995C>T	ENST00000372861.3	+	2	640	c.509C>T	c.(508-510)aCc>aTc	p.T170I		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	170						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				TGTGCCGCCACCCTGGCCCTC	0.687000													12	18					0	0	1	0	0
CLIP4	79745	broad.mit.edu	37	2	29354130	29354130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29354130C>T	ENST00000320081.5	+	3	395	c.140C>T	c.(139-141)tCt>tTt	p.S47F	CLIP4_ENST00000404424.1_Missense_Mutation_p.S47F|CLIP4_ENST00000401605.1_Missense_Mutation_p.S47F|CLIP4_ENST00000401617.2_5'UTR	NM_024692.4	NP_078968.3	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family, member 4	47										endometrium(4)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(1)	26	Acute lymphoblastic leukemia(172;0.155)					TCAGAATTTTCTTTCTTTGAT	0.274000													16	36					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47463690	47463690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47463690C>T	ENST00000285039.7	-	15	2129	c.1830G>A	c.(1828-1830)tcG>tcA	p.S610S		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	610	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CGCTGATCTTCGAAGATGACC	0.532000													25	72					0	0	1	0	0
SERPINB5	5268	broad.mit.edu	37	18	61154191	61154191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61154191G>A	ENST00000382771.4	+	3	473	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	SERPINB5_ENST00000489441.1_Missense_Mutation_p.E61K	NM_002639.4	NP_002630.2	P36952	SPB5_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 5	61					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						TCTTCATTTTGAAAATGTCAA	0.388000													34	79					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33195256	33195256	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:33195256C>T	ENST00000242067.6	+	4	791	c.270C>T	c.(268-270)acC>acT	p.T90T	BBS9_ENST00000396127.2_Silent_p.T90T|BBS9_ENST00000354265.4_Silent_p.T90T|BBS9_ENST00000355070.2_Silent_p.T90T|BBS9_ENST00000350941.3_Silent_p.T90T|BBS9_ENST00000425508.2_Silent_p.T45T	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	90					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			TCAGAGGTACCGAAATGCTAC	0.289000									Bardet-Biedl syndrome				9	32					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97329689	97329689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97329689C>T	ENST00000389672.5	+	13	2603	c.2565C>T	c.(2563-2565)tcC>tcT	p.S855S	EPHA6_ENST00000514100.1_Silent_p.S247S|EPHA6_ENST00000442602.2_Silent_p.S221S|EPHA6_ENST00000502694.1_Silent_p.S247S	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	760	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CCCTAGACTCCTTTTTGCGGG	0.333000													22	61					0	0	1	0	0
CYP26B1	56603	broad.mit.edu	37	2	72360181	72360181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:72360181G>A	ENST00000001146.2	-	5	1320	c.1117C>T	c.(1117-1119)Cgc>Tgc	p.R373C	CYP26B1_ENST00000546307.1_Missense_Mutation_p.R298C|CYP26B1_ENST00000412253.1_Missense_Mutation_p.R182C	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	373					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						AGCACAGTGCGGTAGCCGCCG	0.682000													21	54					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39436236	39436236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39436236G>A	ENST00000257408.4	+	2	1329	c.1232G>A	c.(1231-1233)cGa>cAa	p.R411Q		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	411	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						AACAACCCTCGAATCTTGATT	0.428000													41	111					0	0	1	0	0
ARSG	22901	broad.mit.edu	37	17	66339821	66339821	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66339821C>T	ENST00000448504.2	+	3	1091	c.295C>T	c.(295-297)Cgc>Tgc	p.R99C	ARSG_ENST00000452479.2_5'UTR	NM_014960.4	NP_055775.2	Q96EG1	ARSG_HUMAN	arylsulfatase G	99					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			NS(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	26			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GCTTGGCCTTCGCAATGGAGT	0.607000													17	53					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78212139	78212139	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78212139C>T	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TCTTCTCTTCCTTTAATGTTC	0.552000													57	364					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807307	143807307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143807307C>T	ENST00000408979.2	+	1	701	c.632C>T	c.(631-633)tCc>tTc	p.S211F		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					GGGCCTCTTTCCTTGATTCTG	0.527000													61	169					0	0	1	0	0
C11orf65	160140	broad.mit.edu	37	11	108256664	108256664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108256664G>A	ENST00000525729.1	-	6	692	c.623C>T	c.(622-624)tCt>tTt	p.S208F	C11orf65_ENST00000526725.1_Intron|C11orf65_ENST00000529391.1_Missense_Mutation_p.S257F|C11orf65_ENST00000393084.1_Missense_Mutation_p.S257F			Q8NCR3	CK065_HUMAN	chromosome 11 open reading frame 65	257										endometrium(1)|large_intestine(3)|lung(4)|ovary(2)	10		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		GTTAGCCGAAGAGTTGCTTGT	0.338000													17	215					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21122984	21122984	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21122984G>A	ENST00000261383.3	-	14	2061	c.2062C>T	c.(2062-2064)Caa>Taa	p.Q688*	DNAH3_ENST00000415178.1_Nonsense_Mutation_p.Q688*	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	688	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACTTGGAATTGAATCAGATGG	0.433000													27	95					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94519661	94519661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:94519661C>T	ENST00000375708.3	-	3	554	c.356G>A	c.(355-357)cGa>cAa	p.R119Q	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	119	Ig-like C2-type.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GATTCGCAGTCGTGAACCATA	0.587000													39	136					0	0	1	0	0
SPINK4	27290	broad.mit.edu	37	9	33248459	33248459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33248459G>A	ENST00000379725.1	+	5	442	c.320G>A	c.(319-321)gGc>gAc	p.G107D	SPINK4_ENST00000379721.3_Missense_Mutation_p.G84D|SPINK4_ENST00000379723.1_Missense_Mutation_p.G107D			O60575	ISK4_HUMAN	serine peptidase inhibitor, Kazal type 4	84						extracellular region	serine-type endopeptidase inhibitor activity			lung(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			ATGAAAGATGGCAAATGCTGA	0.483000													13	25					0	0	1	0	0
OASL	8638	broad.mit.edu	37	12	121458439	121458439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121458439C>T	ENST00000257570.5	-	6	1740	c.1470G>A	c.(1468-1470)ggG>ggA	p.G490G	OASL_ENST00000339275.5_3'UTR	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	490	Ubiquitin-like 2.				interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGCCATAGATCCCCAGACCCA	0.517000													22	51					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77642739	77642739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:77642739G>A	ENST00000407578.2	-	70	12398	c.12132C>T	c.(12130-12132)ttC>ttT	p.F4044F	MYCBP2_ENST00000357337.6_Silent_p.F4006F|MYCBP2_ENST00000544440.2_Silent_p.F4006F	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	4006					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GAAGCAGCGAGAAGAGATCCT	0.473000													10	28					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604650	179604650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179604650C>T	ENST00000589042.1	-	48	13534	c.13310G>A	c.(13309-13311)aGa>aAa	p.R4437K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R4074K|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R4266K|TTN_ENST00000359218.5_Missense_Mutation_p.R4199K|TTN_ENST00000591111.1_Missense_Mutation_p.R4120K|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4120	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATGATGTGTCTGGGCTCTTG	0.458000													33	112					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760970	62760970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62760970C>T	ENST00000336232.2	-	10	1590	c.1455G>A	c.(1453-1455)ggG>ggA	p.G485G	SLC22A8_ENST00000535878.1_Silent_p.G362G|SLC22A8_ENST00000545207.1_Silent_p.G394G|SLC22A8_ENST00000430500.2_Silent_p.G485G|SLC22A8_ENST00000311438.8_Silent_p.G485G	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	485					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CAGCACTGCCCCCGAGGAGGG	0.597000													15	120					0	0	1	0	0
HTR3D	200909	broad.mit.edu	37	3	183756207	183756207	+	Silent	SNP	C	C	T	rs139778852		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183756207C>T	ENST00000382489.3	+	7	930	c.930C>T	c.(928-930)ttC>ttT	p.F310F	HTR3D_ENST00000428798.2_Silent_p.F260F|HTR3D_ENST00000334128.2_Silent_p.F135F|HTR3D_ENST00000453435.1_Silent_p.F89F	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	310						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GTGTCTACTTCGCCCTGTGCC	0.587000													29	77					0	0	1	0	0
SIT1	27240	broad.mit.edu	37	9	35650207	35650207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35650207C>T	ENST00000259608.3	-	4	417	c.331G>A	c.(331-333)Gat>Aat	p.D111N	SIT1_ENST00000474403.1_5'UTR	NM_014450.2	NP_055265.1	Q9Y3P8	SIT1_HUMAN	signaling threshold regulating transmembrane adaptor 1	111					regulation of T cell activation|signal transduction	integral to plasma membrane	kinase binding|SH2 domain binding			endometrium(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	9			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGAGTTGGATCCTGCTGGTCT	0.617000													21	45					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540263	133540263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133540263G>A	ENST00000409261.1	-	14	4494	c.4121C>T	c.(4120-4122)cCa>cTa	p.P1374L	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.P1374L	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1374							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTCAGACTTTGGAGGGATCCT	0.617000													24	50					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51412231	51412231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:51412231G>A	ENST00000319760.6	-	1	217	c.165C>T	c.(163-165)tcC>tcT	p.S55S		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	55				GSP -> CSA (in Ref. 1; BAC05754).	sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				AATACATTGGGGAACCCAAGG	0.403000													18	55					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71092118	71092118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71092118C>T	ENST00000283228.2	-	8	1658	c.1206G>A	c.(1204-1206)atG>atA	p.M402I	PTPRR_ENST00000549308.1_Missense_Mutation_p.M157I|PTPRR_ENST00000378778.1_Missense_Mutation_p.M196I|PTPRR_ENST00000440835.2_Missense_Mutation_p.M157I|PTPRR_ENST00000342084.4_Missense_Mutation_p.M290I	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	402	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CCACAAAGTTCATTGGTATTT	0.338000													19	56					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57423014	57423014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57423014G>A	ENST00000442789.2	-	28	3194	c.2907C>T	c.(2905-2907)ttC>ttT	p.F969F	MYO1A_ENST00000300119.3_Silent_p.F969F|MYO1A_ENST00000544473.1_Silent_p.F807F	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	969					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TGACCAGCAGGAAGTCCCCCT	0.512000													33	68					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	14066290	14066290	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:14066290C>T	ENST00000217246.4	+	3	582	c.187C>T	c.(187-189)Cag>Tag	p.Q63*	MACROD2_ENST00000310348.4_Nonsense_Mutation_p.Q63*	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	63	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				GGAAACATCCCAGGTGAAGAA	0.303000													19	61					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42683086	42683086	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42683086C>T	ENST00000358131.5	+	5	1034	c.826C>T	c.(826-828)Cag>Tag	p.Q276*	TOX2_ENST00000372999.1_Nonsense_Mutation_p.Q225*|TOX2_ENST00000435864.2_Nonsense_Mutation_p.Q145*|TOX2_ENST00000423191.1_Nonsense_Mutation_p.Q225*|TOX2_ENST00000341197.3_Nonsense_Mutation_p.Q267*	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CATCAAGGGTCAGAACCCCAG	0.562000													8	57					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497619	1497619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1497619C>T	ENST00000421627.2	+	2	894	c.760C>T	c.(760-762)Ccc>Tcc	p.P254S		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	333					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GCTGCAGAGCCCCTTCGGGGA	0.662000													14	112					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735502	140735502	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140735502C>T	ENST00000571252.1	+	1	735	c.735C>T	c.(733-735)ccC>ccT	p.P245P	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCACTCAGCCCGAGTACCACG	0.532000													15	26					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307236	14307236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:14307236G>A	ENST00000378053.3	-	2	1173	c.917C>T	c.(916-918)cCc>cTc	p.P306L	MACROD2_ENST00000217246.4_Intron|FLRT3_ENST00000341420.4_Missense_Mutation_p.P306L|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	306	LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GCAATACCAGGGATTGTTGCG	0.438000													37	77					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98408551	98408551	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98408551G>A	ENST00000339364.5	-	7	1169	c.1050C>T	c.(1048-1050)aaC>aaT	p.N350N	PIK3AP1_ENST00000371110.2_Silent_p.N172N|PIK3AP1_ENST00000468783.1_5'UTR	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	350						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		AGGCAGTGAGGTTCTTCAGTC	0.507000													10	38					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16910772	16910772	+	Missense_Mutation	SNP	C	C	T	rs140495987		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16910772C>T	ENST00000524140.2	+	17	3953	c.3535C>T	c.(3535-3537)Cgc>Tgc	p.R1179C	NWD1_ENST00000523826.1_Missense_Mutation_p.R973C|NWD1_ENST00000379808.3_Missense_Mutation_p.R1179C|NWD1_ENST00000339803.6_Missense_Mutation_p.R1044C|NWD1_ENST00000552788.1_Missense_Mutation_p.R1179C|NWD1_ENST00000549814.1_Intron	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1179							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CCTGCTGGCCCGCGGCGGGGC	0.622000													17	63					0	0	1	0	0
SPATA19	219938	broad.mit.edu	37	11	133714162	133714162	+	Missense_Mutation	SNP	C	C	T	rs138223153		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:133714162C>T	ENST00000299140.3	-	4	392	c.338G>A	c.(337-339)cGa>cAa	p.R113Q	SPATA19_ENST00000532889.1_Missense_Mutation_p.R113Q	NM_174927.1	NP_777587.1	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19	113					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane				cervix(1)|endometrium(2)|large_intestine(2)|lung(5)|prostate(1)	11	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		GAACTGGATTCGTGTTCTCTC	0.537000													30	95					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71796724	71796724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:71796724G>A	ENST00000269500.5	-	5	808	c.473C>T	c.(472-474)cCa>cTa	p.P158L	FBXO15_ENST00000419743.2_Missense_Mutation_p.P234L	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	158										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		TGCTAGGCATGGCCATTTTTT	0.373000													15	37					0	0	1	0	0
KLHL24	54800	broad.mit.edu	37	3	183381334	183381334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183381334C>T	ENST00000454652.1	+	5	1395	c.1009C>T	c.(1009-1011)Cct>Tct	p.P337S	KLHL24_ENST00000242810.6_Missense_Mutation_p.P337S|KLHL24_ENST00000476808.1_Missense_Mutation_p.P337S			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	337						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GTGCTACGATCCTGTAACAGG	0.413000													41	121					0	0	1	0	0
TNNT3	7140	broad.mit.edu	37	11	1955049	1955049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1955049C>T	ENST00000381558.1	+	9	525	c.246C>T	c.(244-246)gtC>gtT	p.V82V	TNNT3_ENST00000360603.3_Silent_p.V84V|TNNT3_ENST00000446240.1_Silent_p.V71V|TNNT3_ENST00000381548.3_Silent_p.V92V|TNNT3_ENST00000381549.3_Silent_p.V82V|TNNT3_ENST00000381589.3_Silent_p.V88V|TNNT3_ENST00000381561.4_Silent_p.V93V|TNNT3_ENST00000278317.6_Silent_p.V90V|TNNT3_ENST00000381579.3_Silent_p.V82V|TNNT3_ENST00000397301.1_Silent_p.V101V|TNNT3_ENST00000397304.2_Silent_p.V71V			P45378	TNNT3_HUMAN	troponin T type 3 (skeletal, fast)	101					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(4)|stomach(1)	19		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		AGGAGCTGGTCGCTCTCAAAG	0.597000													18	68					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911199	230911199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230911199C>T	ENST00000295190.4	-	4	1101	c.643G>A	c.(643-645)Ggt>Agt	p.G215S		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	215						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		GGGTTTTTACCAGGAGAGAGG	0.552000													43	81					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577796	9577796	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9577796G>A	ENST00000301480.4	-	10	2040	c.1827C>T	c.(1825-1827)ttC>ttT	p.F609F		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	609					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						AGCGTTCTGTGAAGGCTTTTC	0.423000													47	143					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56480866	56480866	+	Missense_Mutation	SNP	G	G	A	rs140472004		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56480866G>A	ENST00000370765.6	-	24	7506	c.7399C>T	c.(7399-7401)Cgt>Tgt	p.R2467C	DST_ENST00000361203.3_Intron|DST_ENST00000312431.6_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000244364.6_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1763					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AAATTTCTACGGGAGGCTTTT	0.493000													13	136					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123249380	123249380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123249380C>T	ENST00000264501.4	+	66	11490	c.11117C>T	c.(11116-11118)tCa>tTa	p.S3706L	KIAA1109_ENST00000388738.3_Missense_Mutation_p.S3706L			Q2LD37	K1109_HUMAN	KIAA1109	3706					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GGAGGCTTTTCACCAGGCATT	0.443000													48	107					0	0	1	0	0
OR6C74	254783	broad.mit.edu	37	12	55641666	55641666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55641666C>T	ENST00000343870.4	+	1	685	c.595C>T	c.(595-597)Ctc>Ttc	p.L199F		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						AATGATGCTTCTCTCAGCCAT	0.393000													26	74					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14533190	14533190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14533190G>A	ENST00000358970.5	-	5	924	c.925C>T	c.(925-927)Ctc>Ttc	p.L309F	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	309										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GCAAGTATGAGGGCAGTTCTA	0.343000													28	97					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934842	113934842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113934842G>A	ENST00000335953.4	+	2	1200	c.820G>A	c.(820-822)Gaa>Aaa	p.E274K	ZBTB16_ENST00000392996.2_Missense_Mutation_p.E274K	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	274					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding	p.E274*(1)		central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CAAGGTTGAGGAAAGAGGCAA	0.627000													19	31					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48685383	48685383	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48685383G>A	ENST00000544264.1	-	21	7315	c.7035C>T	c.(7033-7035)gcC>gcT	p.A2345A	CELSR3_ENST00000164024.4_Silent_p.A2340A			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2340					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTAGCGACGGGCCCCCCGGG	0.632000													43	150					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221131	161221131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161221131C>T	ENST00000327928.4	+	4	835	c.835C>T	c.(835-837)Cgt>Tgt	p.R279C		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	279	Collagen-like 3.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						CAAAAGCGGCCGTAATGGTCT	0.537000													6	8					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74825080	74825080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74825080C>T	ENST00000256362.4	+	2	1835	c.1594C>T	c.(1594-1596)Cgc>Tgc	p.R532C		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	532					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CTTCCGCCTCCGCTACCCCAG	0.647000													52	148					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61463559	61463559	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61463559G>A	ENST00000398019.2	+	5	721	c.396G>A	c.(394-396)acG>acA	p.T132T	SERPINB7_ENST00000336429.2_Silent_p.T132T|SERPINB7_ENST00000546027.1_Silent_p.T132T|SERPINB7_ENST00000540675.1_Silent_p.T115T	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	132					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity	p.T132T(1)		central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				TTGACTTTACGAATCATTTAG	0.333000													21	62					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995918	140995918	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140995918G>A	ENST00000285879.4	+	4	3014	c.2728G>A	c.(2728-2730)Gaa>Aaa	p.E910K	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	910	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TACACTGGATGAAAAGGTGGA	0.468000										HNSCC(15;0.026)			86	75					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48451736	48451736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48451736G>A	ENST00000358536.4	-	31	5843	c.5574C>T	c.(5572-5574)ctC>ctT	p.L1858L	PLXNB1_ENST00000456774.1_Silent_p.L1675L|PLXNB1_ENST00000296440.6_Silent_p.L1858L|PLXNB1_ENST00000358459.4_Silent_p.L1675L|PLXNB1_ENST00000448774.2_Silent_p.L469L	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1858					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGTTTTCCCGGAGCACATGCT	0.632000													9	37					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458559	45458559	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45458559G>A	ENST00000548424.1	+	0	448																											AGGTCCAGAGGGACCATCAAC	0.473000													15	38					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50682527	50682527	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50682527G>A	ENST00000403097.1	-	11	1797	c.1017C>T	c.(1015-1017)ttC>ttT	p.F339F	GRB10_ENST00000406641.1_Silent_p.F287F|GRB10_ENST00000398810.2_Silent_p.F287F|GRB10_ENST00000439599.1_Silent_p.F339F|GRB10_ENST00000407526.1_Silent_p.F287F|GRB10_ENST00000401949.1_Silent_p.F345F|GRB10_ENST00000357271.5_Silent_p.F299F|GRB10_ENST00000335866.3_Silent_p.F287F|GRB10_ENST00000402578.1_Silent_p.F287F|GRB10_ENST00000398812.2_Silent_p.F345F|GRB10_ENST00000402497.1_Silent_p.F287F			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	345	PH.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					CGATCAGGGAGAAGATGTTGC	0.572000									Russell-Silver syndrome				27	113					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156785878	156785878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156785878C>T	ENST00000392306.2	-	2	182	c.43G>A	c.(43-45)Gaa>Aaa	p.E15K	SH2D2A_ENST00000368198.3_Intron|SH2D2A_ENST00000368199.3_Missense_Mutation_p.E15K|SH2D2A_ENST00000495306.1_5'UTR|NTRK1_ENST00000392302.2_Intron	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	15					angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ATGGGGGCTTCGTGACTCCCT	0.612000													4	29					0	0	1	0	0
UBQLN4	56893	broad.mit.edu	37	1	156018388	156018388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156018388G>A	ENST00000368309.3	-	5	896	c.804C>T	c.(802-804)gcC>gcT	p.A268A	UBQLN4_ENST00000472638.1_5'UTR|UBQLN4_ENST00000368307.1_Intron	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	268						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					GGTTGCTCAGGGCCCGGTCCT	0.582000													28	52					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881311	228881311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228881311G>A	ENST00000392056.3	-	7	4305	c.4259C>T	c.(4258-4260)tCa>tTa	p.S1420L	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S1420L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1420						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CGAGCAAAGTGATCGCCTTTT	0.458000													52	106					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26694975	26694975	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26694975C>T	ENST00000529632.2	+	5	1384	c.1188C>T	c.(1186-1188)ccC>ccT	p.P396P	SEZ6L_ENST00000343706.4_Silent_p.P396P|SEZ6L_ENST00000360929.3_Silent_p.P396P|SEZ6L_ENST00000404234.3_Silent_p.P396P|SEZ6L_ENST00000248933.6_Silent_p.P396P|SEZ6L_ENST00000402979.1_Silent_p.P169P|SEZ6L_ENST00000403121.1_Silent_p.P169P	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	396	Sushi 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GCAACTTTCCCCGCCGGCCTG	0.587000													20	49					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813469	106813469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106813469C>T	ENST00000407775.2	+	8	1409	c.1159C>T	c.(1159-1161)Cct>Tct	p.P387S	ZFPM2_ENST00000520492.1_Missense_Mutation_p.P255S|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.P118S|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.P255S|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	387					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GCTCCATGTCCCTAGCGGCAA	0.512000													60	95					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45817476	45817476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45817476G>A	ENST00000358525.4	-	4	474	c.359C>T	c.(358-360)cCc>cTc	p.P120L	SLC6A20_ENST00000353278.4_Missense_Mutation_p.P120L|SLC6A20_ENST00000456124.2_Missense_Mutation_p.P120L	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	120					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CCACGGCAGGGGATCCTGTGG	0.582000													33	60					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71532629	71532629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71532629G>A	ENST00000265382.3	+	9	1242	c.937G>A	c.(937-939)Ggt>Agt	p.G313S	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.G313S	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	313	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		ATCTATCCAGGGTCCAGGGAA	0.527000													24	94					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996099	140996099	+	Missense_Mutation	SNP	C	C	T	rs143297640		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140996099C>T	ENST00000285879.4	+	4	3195	c.2909C>T	c.(2908-2910)cCt>cTt	p.P970L	MAGEC1_ENST00000406005.2_Missense_Mutation_p.P37L	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	970	MAGE.						protein binding	p.P970H(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGTGGACCCTGATGACTCC	0.478000										HNSCC(15;0.026)			75	60					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53007622	53007622	+	Silent	SNP	G	G	A	rs143904861		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53007622G>A	ENST00000305748.3	-	5	868	c.834C>T	c.(832-834)atC>atT	p.I278I	RP11-641A6.2_ENST00000552364.1_RNA|RP11-641A6.2_ENST00000549180.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	278	Coil 1B.|Rod.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTGGGACTGGATCTGAGCAG	0.567000													31	92					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114379287	114379287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:114379287G>A	ENST00000312719.5	-	5	1363	c.175C>T	c.(175-177)Cgc>Tgc	p.R59C	HS3ST5_ENST00000411826.1_Missense_Mutation_p.R59C|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	59					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TGCAGGGCGCGAAGTGGGAAT	0.577000													12	20					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120389297	120389297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120389297C>T	ENST00000283871.5	-	4	718	c.259G>A	c.(259-261)Gaa>Aaa	p.E87K	HGD_ENST00000488183.1_5'UTR	NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	87					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		GGATCAACTTCATCCCAGTTG	0.423000													33	111					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78917448	78917448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78917448C>T	ENST00000412074.2	-	5	656	c.545G>A	c.(544-546)gGa>gAa	p.G182E	CHRNB4_ENST00000261751.3_3'UTR	NM_001256567.1	NP_001243496.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	0					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CCACTCACATCCTCTCACCCC	0.597000													33	119					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103294589	103294589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103294589C>T	ENST00000424685.2	-	13	1664	c.1505G>A	c.(1504-1506)gGa>gAa	p.G502E	RELN_ENST00000343529.5_Missense_Mutation_p.G502E|RELN_ENST00000428762.1_Missense_Mutation_p.G502E			P78509	RELN_HUMAN	reelin	502					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTCTTTTCTTCCTTCAATTTT	0.398000													28	79					0	0	1	0	0
C20orf85	128602	broad.mit.edu	37	20	56735761	56735761	+	Silent	SNP	C	C	T	rs61749694	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56735761C>T	ENST00000371168.3	+	4	358	c.297C>T	c.(295-297)atC>atT	p.I99I		NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85	99			I -> V (in dbSNP:rs17440813).							kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			AGGGCTTCATCGGCTGGAGAT	0.577000													7	43					0	0	1	0	0
ELF4	2000	broad.mit.edu	37	X	129205174	129205174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:129205174G>A	ENST00000308167.5	-	7	1029	c.650C>T	c.(649-651)gCt>gTt	p.A217V	ELF4_ENST00000335997.7_Missense_Mutation_p.A217V	NM_001421.3	NP_001412.1	Q99607	ELF4_HUMAN	E74-like factor 4 (ets domain transcription factor)	217					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						TTGCAGAAGAGCCAGGAGGAA	0.597000			T	ERG	AML								45	27					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78443370	78443370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78443370C>T	ENST00000278550.7	-	21	3591	c.3129G>A	c.(3127-3129)ccG>ccA	p.P1043P		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CCTGAATTTCCGGCACAATGG	0.517000													16	39					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4835915	4835915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4835915C>T	ENST00000252318.2	+	2	766	c.429C>T	c.(427-429)ctC>ctT	p.L143L	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	143						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CCCAGGACCTCTTCCGGAAGT	0.557000													13	57					0	0	1	0	0
C9orf43	257169	broad.mit.edu	37	9	116175776	116175776	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116175776G>A	ENST00000288462.4	+	2	449	c.3G>A	c.(1-3)atG>atA	p.M1I	C9orf43_ENST00000374165.1_Start_Codon_SNP_p.M1I|C9orf43_ENST00000490544.1_3'UTR	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	1										breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						TTCTAGCTATGGACTTGCCAG	0.498000													17	27					0	0	1	0	0
ABTB2	25841	broad.mit.edu	37	11	34218898	34218898	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:34218898G>A	ENST00000435224.2	-	3	1642	c.1218C>T	c.(1216-1218)ccC>ccT	p.P406P	ABTB2_ENST00000530814.1_5'UTR|ABTB2_ENST00000298992.2_Silent_p.P220P	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	220							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				TCATTCTCGGGGGGTCCAGGT	0.587000													28	30					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018323	1018323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1018323C>T	ENST00000398484.2	+	7	1523	c.943C>T	c.(943-945)Ccc>Tcc	p.P315S	FGFRL1_ENST00000510644.1_Missense_Mutation_p.P315S|FGFRL1_ENST00000264748.6_Missense_Mutation_p.P315S|FGFRL1_ENST00000504138.1_Missense_Mutation_p.P315S			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	315	Ig-like C2-type 3.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GTGGTCGCGGCCCGACGGCTC	0.647000													18	74					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5968191	5968191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:5968191C>T	ENST00000399933.3	-	3	2039	c.2040G>A	c.(2038-2040)atG>atA	p.M680I	KIAA2026_ENST00000381461.2_Missense_Mutation_p.M680I	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	680	Lys-rich.									breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTTTTGCCCTCATTTTAGTTA	0.343000													3	20					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118500911	118500911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:118500911C>T	ENST00000311085.8	+	21	4986	c.4906C>T	c.(4906-4908)Cct>Tct	p.P1636S	DMXL1_ENST00000539542.1_Missense_Mutation_p.P1636S	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1636										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AAAGAATGATCCTTTAGATGC	0.289000													23	73					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242151616	242151616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242151616G>A	ENST00000274979.8	+	16	1934	c.1831G>A	c.(1831-1833)Ggc>Agc	p.G611S	ANO7_ENST00000402430.3_Missense_Mutation_p.G610S	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	611						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						CTTCTTCAAGGGCAGGTTGGT	0.582000													20	60					0	0	1	0	0
PTH2R	5746	broad.mit.edu	37	2	209358274	209358274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:209358274G>A	ENST00000272847.2	+	13	1756	c.1543G>A	c.(1543-1545)Gaa>Aaa	p.E515K	AC019185.4_ENST00000424628.1_RNA|PTH2R_ENST00000413482.1_3'UTR	NM_005048.2	NP_005039.1	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor	515						integral to plasma membrane	parathyroid hormone receptor activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(21)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GGAGACCAAGGAAGATAGTGG	0.522000													19	50					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53459007	53459007	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:53459007T>A	ENST00000331173.4	-	1	348	c.303A>T	c.(301-303)ttA>ttT	p.L101F	PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373985.1_Intron|PRKG1_ENST00000373980.4_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	101					mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		CAAGGCTCTTTAACTCCTCCT	0.552000													67	143					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995889	140995889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140995889G>A	ENST00000285879.4	+	4	2985	c.2699G>A	c.(2698-2700)aGc>aAc	p.S900N	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	900							protein binding	p.S900I(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTGATAGAGAGCGAGCCCTTG	0.473000										HNSCC(15;0.026)			82	82					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57910260	57910260	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57910260C>T	ENST00000574161.1	+	3	311	c.192C>T	c.(190-192)acC>acT	p.T64T	GCOM1_ENST00000396180.1_Silent_p.T64T|GCOM1_ENST00000380560.2_Silent_p.T64T|GCOM1_ENST00000380561.2_Silent_p.T64T|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Silent_p.T64T|GCOM1_ENST00000572390.1_Silent_p.T64T|MYZAP_ENST00000267853.5_Silent_p.T64T|GCOM1_ENST00000587652.1_Silent_p.T64T|MYZAP_ENST00000380565.4_Silent_p.T64T|GCOM1_ENST00000380568.3_Silent_p.T64T	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		64					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GAGAACCTACCAGGAAACTTC	0.433000													20	83					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739797	38739797	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38739797G>A	ENST00000449082.2	-	27	4913	c.4914C>T	c.(4912-4914)atC>atT	p.I1638I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1638					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACATGTCGTCGATGCCAGCCT	0.552000													48	125					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192701300	192701300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:192701300G>A	ENST00000304141.4	-	2	956	c.627C>T	c.(625-627)ccC>ccT	p.P209P		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	209						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CCTCATCGTGGGGCAAATCAT	0.522000													32	101					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37707063	37707063	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37707063C>T	ENST00000248901.6	+	10	1030	c.843C>T	c.(841-843)ttC>ttT	p.F281F		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	281	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						GGCGCTGGTTCATCCTGACCG	0.627000													58	126					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50679123	50679123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50679123G>A	ENST00000355832.5	-	17	3046	c.2968C>T	c.(2968-2970)Cca>Tca	p.P990S	ERCC6_ENST00000542458.1_Missense_Mutation_p.P360S|RP11-123B3.2_ENST00000423283.1_RNA	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	990	Helicase C-terminal.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CTTTGTTTTGGGTCTTTTAGC	0.348000								Direct reversal of damage;Nucleotide excision repair (NER)					24	119					0	0	1	0	0
P2RY12	64805	broad.mit.edu	37	3	151056190	151056190	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151056190G>A	ENST00000302632.3	-	3	743	c.444C>T	c.(442-444)atC>atT	p.I148I	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	148					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	TGAATGCCCAGATGACAACAG	0.438000													31	84					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22155537	22155537	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22155537G>A	ENST00000397126.4	-	4	2447	c.2299C>T	c.(2299-2301)Cat>Tat	p.H767Y	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTTTCTTATGATAACTAAGG	0.358000													30	43					0	0	1	0	0
MAGEA11	4110	broad.mit.edu	37	X	148796219	148796219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:148796219G>A	ENST00000355220.5	+	3	277	c.175G>A	c.(175-177)Gat>Aat	p.D59N	MAGEA11_ENST00000333104.4_Missense_Mutation_p.D30N	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	59						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GTGGTCCCAGGATCTGCCAAG	0.532000													16	3					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	160994281	160994281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160994281C>T	ENST00000283249.2	-	10	1561	c.1324G>A	c.(1324-1326)Gat>Aat	p.D442N	ITGB6_ENST00000428609.2_Missense_Mutation_p.D400N|ITGB6_ENST00000409967.2_Missense_Mutation_p.D442N|ITGB6_ENST00000409872.1_Missense_Mutation_p.D442N			P18564	ITB6_HUMAN	integrin, beta 6	442					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						TCCAGGGCATCCCCCAGCCCC	0.493000													7	75					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66204690	66204690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:66204690G>A	ENST00000503581.1	-	4	1151	c.614C>T	c.(613-615)cCa>cTa	p.P205L	EYS_ENST00000393380.2_Missense_Mutation_p.P205L|EYS_ENST00000370616.2_Missense_Mutation_p.P205L|EYS_ENST00000370618.3_Missense_Mutation_p.P205L|EYS_ENST00000370621.3_Missense_Mutation_p.P205L|EYS_ENST00000342421.5_Missense_Mutation_p.P205L	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	205	EGF-like 1.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						TCCAGAAAATGGAGGCTGGCA	0.393000													16	45					0	0	1	0	0
IGSF11	152404	broad.mit.edu	37	3	118621455	118621455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:118621455G>A	ENST00000354673.2	-	9	1585	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	IGSF11_ENST00000491903.1_Missense_Mutation_p.S375F|IGSF11_ENST00000425327.2_Missense_Mutation_p.S402F|IGSF11_ENST00000489689.1_Missense_Mutation_p.S379F|IGSF11_ENST00000393775.2_Missense_Mutation_p.S403F|IGSF11_ENST00000441144.2_Missense_Mutation_p.S378F	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	403					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GATGGTGTAGGAATGAGTGTG	0.547000													37	89					0	0	1	0	0
TMEM35	59353	broad.mit.edu	37	X	100349772	100349772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:100349772C>T	ENST00000372930.4	+	2	614	c.331C>T	c.(331-333)Cct>Tct	p.P111S	TMEM35_ENST00000478351.1_3'UTR	NM_021637.2	NP_067650.1	Q53FP2	TMM35_HUMAN	transmembrane protein 35	111						cytoplasmic membrane-bounded vesicle|integral to membrane|peroxisomal membrane				NS(1)|large_intestine(3)|liver(1)|skin(1)|urinary_tract(1)	7						GGTCGGTGATCCTCTCAAACG	0.567000													45	46					0	0	1	0	0
SEC1P	653677	broad.mit.edu	37	19	49183691	49183691	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49183691G>A	ENST00000430145.2	+	0	778					NR_004401.2																						GCCACATCCCGGGGCGCTGTG	0.657000													18	31					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160147345	160147345	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160147345T>G	ENST00000368081.4	+	18	3098	c.2627T>G	c.(2626-2628)tTt>tGt	p.F876C	ATP1A4_ENST00000418334.1_3'UTR|ATP1A4_ENST00000470705.1_Missense_Mutation_p.F12C	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	876					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTTACCTACTTTGTAATCCTG	0.522000													29	87					0	0	1	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090203	238090203	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:238090203G>A	ENST00000450451.1	+	0	1709					NR_027247.2																						TGCTGGGGACGATGCCCCCCA	0.602000													6	19					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275274	71275274	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71275274C>T	ENST00000399575.2	+	3	403	c.229C>T	c.(229-231)Cga>Tga	p.R77*	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	77	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				TTCTTTCTCTCGATTTAGCCA	0.458000													76	204					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5540495	5540495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5540495G>A	ENST00000382368.3	-	3	1528	c.1405C>T	c.(1405-1407)Ccc>Tcc	p.P469S	FBXL18_ENST00000453700.3_Missense_Mutation_p.P469S	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	469									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GAGGGCTGGGGGCACGCCTGG	0.667000													14	20					0	0	1	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176752	142176752	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142176752G>A	ENST00000390369.2	-	0	38																											CTGTCCCTAGGAAACCCAGGA	0.507000													42	86					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10073501	10073501	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10073501C>T	ENST00000264828.3	-	65	4930	c.4845G>A	c.(4843-4845)ggG>ggA	p.G1615G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1615	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCACCTTCTTCCCTCGACGGA	0.552000													11	15					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248031355	248031355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248031355G>A	ENST00000366481.3	+	5	909	c.861G>A	c.(859-861)agG>agA	p.R287R	OR2W3_ENST00000537741.1_5'UTR	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	287	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGCTCTTAAGGAAGTTCCAAG	0.507000													3	15					0	0	1	0	0
MAGEA5	4104	broad.mit.edu	37	X	151284190	151284190	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151284190G>A	ENST00000509345.2	-	0	221																											GGCCTCCTGGGGATCCTCTGG	0.532000													11	11					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41066305	41066305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41066305C>T	ENST00000352632.3	+	27	5997	c.5911C>T	c.(5911-5913)Ccc>Tcc	p.P1971S	SPTBN4_ENST00000392023.1_Missense_Mutation_p.P647S|SPTBN4_ENST00000392025.1_Missense_Mutation_p.P714S|SPTBN4_ENST00000595535.1_Missense_Mutation_p.P1971S|SPTBN4_ENST00000598249.1_Missense_Mutation_p.P1971S|SPTBN4_ENST00000338932.3_Missense_Mutation_p.P1971S			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1971					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGCCGACAAGCCCAGGTGCCC	0.657000													36	45					0	0	1	0	0
OR56A4	120793	broad.mit.edu	37	11	6023314	6023314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6023314C>T	ENST00000330728.4	-	1	1110	c.1065G>A	c.(1063-1065)aaG>aaA	p.K355K		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K355N(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGATTCCCTGCTTGATCTCCT	0.433000													31	53					0	0	1	0	0
EAF2	55840	broad.mit.edu	37	3	121591511	121591511	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121591511C>T	ENST00000273668.2	+	5	683	c.612C>T	c.(610-612)tcC>tcT	p.S204S	EAF2_ENST00000451944.2_Silent_p.S204S	NM_018456.4	NP_060926.2	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	204	Necessary for transactivation activity.|Ser-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding	p.S204S(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)	9				GBM - Glioblastoma multiforme(114;0.0972)		ATTGCAAATCCTCTACTTCTG	0.393000													21	125					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7759687	7759687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7759687G>A	ENST00000358415.4	+	6	732	c.566G>A	c.(565-567)aGg>aAg	p.R189K	ITIH2_ENST00000379587.4_Missense_Mutation_p.R178K|ITIH2_ENST00000480387.1_3'UTR	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	189					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						GTGAAGTGGAGGAAGCTGGGC	0.522000													51	144					0	0	1	0	0
NECAB3	63941	broad.mit.edu	37	20	32258570	32258570	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32258570G>A	ENST00000246190.6	-	3	238	c.183C>T	c.(181-183)ttC>ttT	p.F61F	NECAB3_ENST00000375238.4_Silent_p.F61F	NM_031232.3	NP_112509.3	Q96P71	NECA3_HUMAN	N-terminal EF-hand calcium binding protein 3	61	EF-hand.				antibiotic biosynthetic process|protein metabolic process|protein secretion|regulation of amyloid precursor protein biosynthetic process	endoplasmic reticulum membrane|Golgi cis cisterna|nucleus	calcium ion binding|oxidoreductase activity|protein binding			large_intestine(3)|lung(5)|skin(2)	10						AGTAATTCTGGAATTCCTCAA	0.592000													13	40					0	0	1	0	0
TUSC2	11334	broad.mit.edu	37	3	50363574	50363574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50363574G>A	ENST00000232496.4	-	3	454	c.311C>T	c.(310-312)cCt>cTt	p.P104L	TUSC2_ENST00000462137.1_Intron	NM_007275.1	NP_009206.1	O75896	TUSC2_HUMAN	tumor suppressor candidate 2	104					cell cycle|cell proliferation|cell-cell signaling		protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GAGGATCACAGGGAAATCCAC	0.577000													3	12					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520385	33520385	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33520385C>T	ENST00000297307.5	-	1	1027	c.942G>A	c.(940-942)ggG>ggA	p.G314G		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	314	DUF6 2.					integral to membrane											CCAGCACAACCCCTGCCGCCA	0.562000													47	74					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86808051	86808051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86808051G>A	ENST00000441037.2	+	10	1606	c.1511G>A	c.(1510-1512)cGa>cAa	p.R504Q	AGBL1_ENST00000421325.2_Missense_Mutation_p.R504Q|AGBL1_ENST00000389298.3_Missense_Mutation_p.R235Q	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	504					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						ATGTTGGAACGAAAATGTGGA	0.443000													35	56					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73464833	73464833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73464833G>A	ENST00000224721.6	+	24	2919	c.2914G>A	c.(2914-2916)Gcc>Acc	p.A972T	CDH23_ENST00000299366.7_Missense_Mutation_p.A1012T	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	967	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCGGGTGGTGGCCAGTGATGC	0.667000													27	41					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124591827	124591827	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124591827T>C	ENST00000368904.1	-	11	2740	c.1791A>G	c.(1789-1791)gcA>gcG	p.A597A	CUZD1_ENST00000545804.1_Silent_p.A597A|CUZD1_ENST00000392790.1_Silent_p.A597A			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	597					cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		ATTTGTAGTCTGCCCGTTGAT	0.448000													21	215					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6937593	6937593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6937593G>A	ENST00000312053.4	+	20	2626	c.2589G>A	c.(2587-2589)acG>acA	p.T863T	EMR1_ENST00000450315.3_Silent_p.T686T|EMR1_ENST00000381404.4_Silent_p.T844T|EMR1_ENST00000250572.8_Silent_p.T798T|EMR1_ENST00000381407.5_Silent_p.T722T	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	863					cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CTGGGAAGACGAAGCCCAGCT	0.557000													29	131					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299207	58299207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58299207G>A	ENST00000377918.3	+	4	3285	c.3259G>A	c.(3259-3261)Gac>Aac	p.D1087N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1087					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCAACCAAGAGACCCTCCCTT	0.532000													38	102					0	0	1	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32713809	32713809	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32713809G>A	ENST00000374940.3	+	3	675	c.573G>A	c.(571-573)gtG>gtA	p.V191V		NM_020056.4	NP_064440.1	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ alpha 2	191	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			endometrium(2)|large_intestine(3)|lung(7)|skin(1)	13					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACTGCAAGGTGGAGCACTGGG	0.473000													15	216					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5672668	5672668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5672668C>T	ENST00000356134.5	-	27	2868	c.2797G>A	c.(2797-2799)Gac>Aac	p.D933N	ANO2_ENST00000327087.8_Missense_Mutation_p.D932N|ANO2_ENST00000546188.1_Missense_Mutation_p.D933N	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	937						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TTGATCTGGTCGCTGATGTCC	0.527000													11	63					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129148439	129148439	+	Missense_Mutation	SNP	C	C	T	rs144104600		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:129148439C>T	ENST00000540052.1	+	3	1735	c.1691C>T	c.(1690-1692)cCa>cTa	p.P564L	BCORL1_ENST00000359304.2_Missense_Mutation_p.P564L|BCORL1_ENST00000303743.5_Missense_Mutation_p.P564L|BCORL1_ENST00000218147.7_Missense_Mutation_p.P564L	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	564	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CTTCCAACTCCACAGCCTCTG	0.637000													31	60					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203691724	203691724	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203691724C>G	ENST00000357681.5	+	18	4054	c.2931C>G	c.(2929-2931)aaC>aaG	p.N977K	ATP2B4_ENST00000391954.2_Missense_Mutation_p.N977K|ATP2B4_ENST00000367218.3_Missense_Mutation_p.N977K|ATP2B4_ENST00000341360.2_Missense_Mutation_p.N977K|ATP2B4_ENST00000367219.3_Missense_Mutation_p.N965K	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	977					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATGAAATCAACTCCCGAAAGA	0.463000													22	90					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210970944	210970944	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210970944G>A	ENST00000367007.4	-	9	1909	c.1740C>T	c.(1738-1740)ctC>ctT	p.L580L	KCNH1_ENST00000271751.4_Silent_p.L607L	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	607					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CATGGTAGATGAGGTCCCCTG	0.602000													43	77					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96163655	96163655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:96163655G>A	ENST00000453304.1	-	7	1381	c.1033C>T	c.(1033-1035)Ccc>Tcc	p.P345S	UNC5C_ENST00000506749.1_Missense_Mutation_p.P345S	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	345	TSP type-1 2.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CCATTCTTGGGGGCTGGCGCC	0.567000													12	25					0	0	1	0	0
MAP1S	55201	broad.mit.edu	37	19	17838113	17838113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17838113C>T	ENST00000324096.4	+	5	2071	c.1920C>T	c.(1918-1920)tcC>tcT	p.S640S	MAP1S_ENST00000544059.2_Silent_p.S614S|MAP1S_ENST00000597681.1_3'UTR	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	640	Necessary for the microtubule-organizing center localization.|Pro-rich.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						GCACACCCTCCCCTGAGTCCC	0.726000													5	8					0	0	1	0	0
BCL2L15	440603	broad.mit.edu	37	1	114424416	114424416	+	Silent	SNP	G	G	A	rs114942995	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114424416G>A	ENST00000393316.3	-	3	624	c.453C>T	c.(451-453)ttC>ttT	p.F151F	BCL2L15_ENST00000471267.1_Intron|BCL2L15_ENST00000488450.1_5'UTR|BCL2L15_ENST00000393320.3_Intron|AP4B1-AS1_ENST00000419536.1_RNA	NM_001010922.2	NP_001010922.1	Q5TBC7	B2L15_HUMAN	BCL2-like 15	151					apoptosis					breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(3)|ovary(1)	9	Lung SC(450;0.184)	all_cancers(81;3.95e-08)|all_epithelial(167;9.95e-08)|all_lung(203;1.31e-05)|Lung NSC(69;2.46e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCCCTGGATGAACTCCCGGA	0.493000													6	25					0	0	1	0	0
PATL1	219988	broad.mit.edu	37	11	59406585	59406585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59406585G>A	ENST00000300146.9	-	18	2311	c.2227C>T	c.(2227-2229)Cta>Tta	p.L743L	AP000442.1_ENST00000531108.1_RNA|AP000442.1_ENST00000531311.1_RNA	NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	743	Region C.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						AGGGACACTAGGTTTGTAGGT	0.488000													13	48					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099642	168099642	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168099642C>T	ENST00000409195.1	+	9	1829	c.1740C>T	c.(1738-1740)atC>atT	p.I580I	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Silent_p.I580I|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.I358I	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	405					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTAGATGGATCTTTGAGAATC	0.408000													20	65					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55582700	55582700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55582700C>T	ENST00000361849.3	-	34	5186	c.4792G>A	c.(4792-4794)Gat>Aat	p.D1598N	PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.D1573N|PCDH15_ENST00000395430.1_Missense_Mutation_p.D1593N|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.D1527N|PCDH15_ENST00000320301.6_Missense_Mutation_p.D1596N|PCDH15_ENST00000395432.2_Missense_Mutation_p.D1556N	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1596					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.D1596Y(1)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCTGCAGATCTATGATCTCT	0.468000										HNSCC(58;0.16)			16	173					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717183	222717183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:222717183G>A	ENST00000343410.6	-	2	728	c.670C>T	c.(670-672)Cat>Tat	p.H224Y		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	224					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		TCCCCAGCATGGACCATGGAG	0.642000													26	39					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433101	140433101	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140433101A>G	ENST00000306549.3	+	1	2123	c.2046A>G	c.(2044-2046)agA>agG	p.R682R		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		682					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCATTCTAGAAAGGTAAATC	0.438000													59	195					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6678261	6678261	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6678261G>A	ENST00000245907.6	-	40	4844	c.4752C>T	c.(4750-4752)ttC>ttT	p.F1584F	C3_ENST00000599668.1_5'UTR	NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1584	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGGGGCTGATGAACGTGCGCT	0.592000													21	34					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791924	95791924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95791924C>T	ENST00000260766.3	+	2	1755	c.1121C>T	c.(1120-1122)cCt>cTt	p.P374L	PLCE1_ENST00000371380.2_Missense_Mutation_p.P374L	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	374					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				CCCTTACTGCCTTGTGGGAGA	0.483000													20	66					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93964487	93964487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:93964487C>T	ENST00000369303.4	-	14	2594	c.2410G>A	c.(2410-2412)Gca>Aca	p.A804T		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	804	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GCTTCGGGTGCTGTCCACCTT	0.353000													13	23					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480413	140480413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140480413C>T	ENST00000231130.2	+	1	180	c.180C>T	c.(178-180)gcC>gcT	p.A60A	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		60	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGAACTGGCCGCGAGGGGGG	0.507000													35	79					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743739	81743739	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81743739C>T	ENST00000555447.1	-	6	2328	c.1916G>A	c.(1915-1917)tGg>tAg	p.W639*	STON2_ENST00000267540.2_Nonsense_Mutation_p.W639*	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	639	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GAGCTTGATCCACTTTGTGGT	0.527000													16	45					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109103343	109103343	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:109103343C>T	ENST00000261483.4	+	6	1995	c.943C>T	c.(943-945)Cat>Tat	p.H315Y		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	315					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		CCAGAGAGTTCATTATGCAGT	0.423000													62	139					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757986	8757986	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8757986C>T	ENST00000229335.6	-	3	355	c.252G>A	c.(250-252)tgG>tgA	p.W84*	AICDA_ENST00000537228.1_Nonsense_Mutation_p.W84*	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	84					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					AGCAGGGGCTCCAGGAGGTGA	0.617000													22	51					0	0	1	0	0
DYDC1	143241	broad.mit.edu	37	10	82098192	82098192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:82098192G>A	ENST00000421924.2	-	6	946	c.535C>T	c.(535-537)Cgt>Tgt	p.R179C	DYDC1_ENST00000372202.1_Intron|DYDC1_ENST00000372204.3_Intron			Q8WWB3	DYDC1_HUMAN	DPY30 domain containing 1	0										kidney(1)|large_intestine(3)|skin(1)	5			Colorectal(32;0.229)			aaacaaaaacGAGTTTTTTCA	0.383000													15	47					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112029769	112029769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112029769G>A	ENST00000374566.3	-	4	1034	c.517C>T	c.(517-519)Cgt>Tgt	p.R173C	EPB41L4B_ENST00000374557.4_Missense_Mutation_p.R173C	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	173	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AACTCCTCACGAAGGTTGTTT	0.443000													37	64					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54856251	54856251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:54856251C>T	ENST00000333896.5	+	13	2326	c.1941C>T	c.(1939-1941)atC>atT	p.I647I	SPTBN1_ENST00000356805.4_Silent_p.I660I	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	660					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			AGGAGAAGATCCTGTCCTCGG	0.627000													37	87					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622675	38622675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38622675G>A	ENST00000413689.1	-	17	3168	c.2975C>T	c.(2974-2976)cCc>cTc	p.P992L	SCN5A_ENST00000423572.2_Missense_Mutation_p.P992L|SCN5A_ENST00000425664.1_Missense_Mutation_p.P992L|SCN5A_ENST00000455624.2_Missense_Mutation_p.P992L|SCN5A_ENST00000450102.2_Missense_Mutation_p.P992L|SCN5A_ENST00000449557.2_Missense_Mutation_p.P992L|SCN5A_ENST00000414099.2_Missense_Mutation_p.P992L|SCN5A_ENST00000451551.2_Missense_Mutation_p.P992L|SCN5A_ENST00000333535.4_Missense_Mutation_p.P992L|SCN5A_ENST00000443581.1_Missense_Mutation_p.P992L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	992					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AAGGGCTGCGGGCTTCTGAGG	0.692000													6	14					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167141089	167141089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167141089C>T	ENST00000375387.4	-	12	2191	c.1851G>A	c.(1849-1851)ggG>ggA	p.G617G	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Silent_p.G616G|SCN9A_ENST00000409435.1_Silent_p.G616G|SCN9A_ENST00000303354.6_Silent_p.G617G			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	616						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGTGCATTTTCCCGTTCACCG	0.587000													20	51					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201460056	201460056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:201460056G>A	ENST00000374700.2	+	3	406	c.165G>A	c.(163-165)atG>atA	p.M55I		NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	55	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTACAGTGATGATATCACGAT	0.398000													14	31					0	0	1	0	0
AKR1B15	441282	broad.mit.edu	37	7	134256361	134256361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:134256361G>A	ENST00000457545.2	+	6	701	c.441G>A	c.(439-441)ggG>ggA	p.G147G	AKR1B15_ENST00000423958.1_Silent_p.G119G	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	147							oxidoreductase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						TACAGACTGGGGATGACTTTT	0.418000													10	106					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34174801	34174801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34174801G>A	ENST00000373381.4	-	22	3640	c.3464C>T	c.(3463-3465)cCt>cTt	p.P1155L	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.P28L	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1115	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTAGTTCACAGGAAAGTTGGG	0.483000													19	56					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993665	140993665	+	Missense_Mutation	SNP	C	C	T	rs74966399		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140993665C>T	ENST00000285879.4	+	4	761	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	159							protein binding	p.P159S(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGGGTTTTCCCCAGTCTGT	0.488000										HNSCC(15;0.026)			87	65					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103091352	103091352	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103091352C>T	ENST00000375735.2	+	57	9091	c.8946_splice	c.e57-1	p.P2983_splice	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Splice_Site_p.P2983_splice	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2983	Stalk (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCTCTTTTAGCCTTTAGTCAA	0.303000													38	91					0	0	1	0	0
ASPG	374569	broad.mit.edu	37	14	104571689	104571689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104571689G>A	ENST00000551177.1	+	10	1167	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K	ASPG_ENST00000546892.2_Missense_Mutation_p.E359K|ASPG_ENST00000455920.2_Missense_Mutation_p.E359K|ASPG_ENST00000549809.1_3'UTR	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	359					lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						CCTTCGGGGGGAGATGACGCC	0.677000													5	32					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580505	140580505	+	Silent	SNP	G	G	A	rs57445845	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580505G>A	ENST00000354757.3	+	1	1158	c.1158G>A	c.(1156-1158)ccG>ccA	p.P386P	PCDHB11_ENST00000536699.1_Silent_p.P21P	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		386	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCCATTCCGGAAGACCTCC	0.448000													32	114					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96909112	96909112	+	Missense_Mutation	SNP	G	G	A	rs112200493		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96909112G>A	ENST00000267584.4	+	7	780	c.736G>A	c.(736-738)Gga>Aga	p.G246R		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	246					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TTTTGGCGATGGAACAAATGT	0.423000													60	137					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152861154	152861154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152861154C>T	ENST00000367255.5	-	4	671	c.70G>A	c.(70-72)Gag>Aag	p.E24K	SYNE1_ENST00000466159.2_Missense_Mutation_p.E24K|SYNE1_ENST00000341594.5_Missense_Mutation_p.E24K|SYNE1_ENST00000367248.3_Missense_Mutation_p.E24K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E24K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E24K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E24K|SYNE1_ENST00000413186.2_Missense_Mutation_p.E24K|SYNE1_ENST00000367253.4_Missense_Mutation_p.E24K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	24	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATCTCTTGCTCATCTAGAAGG	0.343000										HNSCC(10;0.0054)			25	48					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447223	226447223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:226447223C>T	ENST00000272907.6	+	4	1503	c.1090C>T	c.(1090-1092)Ccc>Tcc	p.P364S	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	364	Pro-rich.																CACGAAGCTTCCCGTGCTGGA	0.637000													18	31					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26115908	26115908	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26115908G>A	ENST00000313735.6	-	4	478	c.245C>T	c.(244-246)cCa>cTa	p.P82L		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	82					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CACATGCCGTGGGGAGGACAA	0.532000													61	69					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308563	140308563	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140308563C>T	ENST00000253807.2	+	1	2086	c.2086C>T	c.(2086-2088)Ctg>Ttg	p.L696L	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHAC1_ENST00000409700.3_Silent_p.L696L|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTTTATTTCTGGGGTGCTT	0.478000													49	146					0	0	1	0	0
RPL13AP3	645683	broad.mit.edu	37	14	56233097	56233097	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:56233097G>A	ENST00000554458.1	+	0	75				RPL13AP3_ENST00000494676.1_RNA																							AACCCTTTTCGAAGCGCCTAC	0.572000													7	18					0	0	1	0	0
C15orf54	400360	broad.mit.edu	37	15	39544521	39544521	+	Missense_Mutation	SNP	C	C	T	rs140379180	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39544521C>T	ENST00000318578.3	+	2	553	c.185C>T	c.(184-186)cCt>cTt	p.P62L	RP11-624L4.1_ENST00000558209.1_RNA|C15orf54_ENST00000561223.1_Missense_Mutation_p.P62L|RP11-624L4.1_ENST00000561058.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA	NM_207445.2	NP_997328.1	Q8N8G6	CO054_HUMAN	chromosome 15 open reading frame 54	62										NS(1)|haematopoietic_and_lymphoid_tissue(2)|lung(2)	5		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		ACGGAGCTCCCTCTCAGGTTC	0.443000													109	289					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1994036	1994036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1994036G>A	ENST00000382722.5	-	11	1532	c.1170C>T	c.(1168-1170)gcC>gcT	p.A390A	CACNA2D4_ENST00000586184.1_Silent_p.A390A|CACNA2D4_ENST00000585732.1_Silent_p.A306A|CACNA2D4_ENST00000585708.1_Silent_p.A326A|CACNA2D4_ENST00000587995.1_Silent_p.A390A|CACNA2D4_ENST00000588077.1_Silent_p.A326A	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	390	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TTCCTTGCTTGGCCTCTTGGA	0.617000													10	29					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169566	113169566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113169566C>T	ENST00000401783.2	-	38	8650	c.8314G>A	c.(8314-8316)Gcc>Acc	p.A2772T	SVEP1_ENST00000374469.1_Missense_Mutation_p.A2749T|SVEP1_ENST00000297826.5_Missense_Mutation_p.A698T	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2772	Sushi 22.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CATGAAATGGCTTCACAGCGT	0.463000													38	86					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24581994	24581994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24581994C>T	ENST00000358321.3	+	9	1611	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	450	VWFD.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						CCTCCGCCTTCGGAGACCCAC	0.652000													12	24					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142021110	142021110	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142021110G>A	ENST00000390381.3	+	0	399																											CAAGATATCTGATCAAAACGA	0.547000													12	40					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10251308	10251308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10251308C>T	ENST00000256458.4	+	4	550	c.460C>T	c.(460-462)Ctc>Ttc	p.L154F		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	154					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						GCCGGCCTTTCTCCAGCCTCC	0.602000													116	232					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43243836	43243836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43243836C>T	ENST00000255226.6	+	11	2254	c.1438C>T	c.(1438-1440)Cac>Tac	p.H480Y	SLC14A2_ENST00000586448.1_Missense_Mutation_p.H480Y	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	480						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GAGTGTATTTCACATCGAGTG	0.582000													11	26					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47925324	47925324	+	Silent	SNP	C	C	T	rs141356808		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47925324C>T	ENST00000289672.2	-	18	3215	c.3165G>A	c.(3163-3165)gaG>gaA	p.E1055E		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1055	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GCTGACTTCTCTCAGAGCGGC	0.587000													32	89					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579609	140579609	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140579609G>A	ENST00000354757.3	+	1	262	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		88	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCTTAAGTGAAACACTAGA	0.493000													49	96					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27720202	27720202	+	Missense_Mutation	SNP	G	G	A	rs148289865		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27720202G>A	ENST00000264717.2	+	2	215	c.152G>A	c.(151-153)cGa>cAa	p.R51Q	GCKR_ENST00000424318.2_5'UTR	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	51					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					AACATTGTTCGACTGCTAGGG	0.517000													30	50					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168103420	168103420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168103420G>A	ENST00000409195.1	+	9	5607	c.5518G>A	c.(5518-5520)Gat>Aat	p.D1840N	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D1840N|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D1618N	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1665					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TATAAAAGGTGATTTGACATC	0.388000													37	107					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112770152	112770152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:112770152C>T	ENST00000390666.3	-	1	576	c.385G>A	c.(385-387)Gac>Aac	p.D129N	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000416046.2_RNA|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	129	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		ACGTCCAGGTCGTGGCAGTAC	0.562000													10	55					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126134603	126134603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126134603G>A	ENST00000373631.3	+	9	2585	c.2584G>A	c.(2584-2586)Gtc>Atc	p.V862I	CRB2_ENST00000359999.3_Missense_Mutation_p.V862I|CRB2_ENST00000373629.2_Missense_Mutation_p.V530I	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	862						extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						GTGTGAGGAGGTCCCTGATGG	0.617000													15	64					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4841445	4841445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4841445G>A	ENST00000399583.3	-	12	2868	c.2681C>T	c.(2680-2682)cCc>cTc	p.P894L	RADIL_ENST00000538469.1_Missense_Mutation_p.P654L|RADIL_ENST00000536091.1_3'UTR	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	894	Pro-rich.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGTGTGCGGGGGGCCAGCCTG	0.726000													12	14					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18331249	18331249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18331249C>T	ENST00000355502.3	-	10	1543	c.672G>A	c.(670-672)caG>caA	p.Q224Q	PDE4C_ENST00000539010.1_5'UTR|PDE4C_ENST00000594617.2_Silent_p.Q224Q|PDE4C_ENST00000262805.11_Silent_p.Q192Q|PDE4C_ENST00000594465.2_Silent_p.Q224Q|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000447275.2_Silent_p.Q118Q			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	224					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	AGTGCCGGGTCTGCAGCGTCT	0.652000													16	41					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32630909	32630909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32630909G>A	ENST00000242310.4	-	1	4758	c.4669C>T	c.(4669-4671)Cca>Tca	p.P1557S		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1557	Bromo 2.				male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TAATAATCTGGAACAAACTTC	0.388000													32	69					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164732947	164732947	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164732947G>A	ENST00000264382.3	-	33	4025	c.3963C>T	c.(3961-3963)gtC>gtT	p.V1321V		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1321	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTGGCCATTTGACAAAGACAT	0.303000										HNSCC(35;0.089)			18	61					0	0	1	0	0
MIXL1	83881	broad.mit.edu	37	1	226413318	226413318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226413318G>A	ENST00000366810.5	+	2	568	c.504G>A	c.(502-504)acG>acA	p.T168T	MIXL1_ENST00000557734.1_3'UTR|MIXL1_ENST00000542034.1_Silent_p.T176T			Q9H2W2	MIXL1_HUMAN	Mix paired-like homeobox	168					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.109)		GAACTGAAACGAAATGTCTGA	0.557000													37	70					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25423794	25423794	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25423794C>T	ENST00000441592.2	+	0	365																											AGCTCAAGCCCTTCCTGGTGC	0.617000													39	33					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32595859	32595859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32595859G>A	ENST00000286827.3	-	9	2329	c.1858C>T	c.(1858-1860)Cgt>Tgt	p.R620C	TIAM1_ENST00000541036.1_Missense_Mutation_p.R620C|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	620					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CAGCGGAAACGAAACAGGTCC	0.478000													27	76					0	0	1	0	0
FIGN	55137	broad.mit.edu	37	2	164467888	164467888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:164467888G>A	ENST00000333129.3	-	3	768	c.454C>T	c.(454-456)Cct>Tct	p.P152S	FIGN_ENST00000409634.1_Intron|FIGN_ENST00000482917.1_5'UTR	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	152						nuclear matrix	ATP binding|nucleoside-triphosphatase activity	p.P152A(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						GCTACCCCAGGAGAGCTTCCT	0.512000													14	104					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18871008	18871008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:18871008G>A	ENST00000446231.2	-	27	4235	c.3823C>T	c.(3823-3825)Cct>Tct	p.P1275S	SMG1_ENST00000389467.3_Missense_Mutation_p.P1275S			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	1275	FAT.|Interaction with SMG8 and SMG9.		P -> R.		DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AACATGTTAGGAAGCAGTTTT	0.313000													21	40					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128483850	128483850	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128483850G>A	ENST00000325888.8	+	19	3073	c.2811_splice	c.e19-1	p.G938_splice	FLNC_ENST00000346177.6_Splice_Site_p.G938_splice	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	938					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TACCCAACAGGGCAACATGGC	0.527000													76	100					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61652454	61652454	+	Missense_Mutation	SNP	C	C	T	rs141770995		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61652454C>T	ENST00000397985.2	+	6	951	c.695C>T	c.(694-696)cCc>cTc	p.P232L	SERPINB8_ENST00000542677.1_Missense_Mutation_p.P50L|SERPINB8_ENST00000397988.3_Missense_Mutation_p.P232L|SERPINB8_ENST00000493661.1_3'UTR|SERPINB8_ENST00000353706.2_Missense_Mutation_p.P232L	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	232					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				ATTCTGCTTCCCGATGACAAC	0.507000													14	51					0	0	1	0	0
N4BP1	9683	broad.mit.edu	37	16	48580147	48580147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48580147G>A	ENST00000262384.3	-	6	2480	c.2244C>T	c.(2242-2244)ttC>ttT	p.F748F	N4BP1_ENST00000565423.1_Intron	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	748					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				TGTCCCCCACGAACGTGTACT	0.517000													6	87					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103566713	103566713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103566713C>T	ENST00000380069.3	+	1	233	c.157C>T	c.(157-159)Ctg>Ttg	p.L53L		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	53										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CCTGGGCTCCCTGAGGCAGGC	0.657000													7	12					0	0	1	0	0
GBP6	163351	broad.mit.edu	37	1	89844102	89844102	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89844102G>A	ENST00000370456.4	+	5	648	c.555G>A	c.(553-555)ctG>ctA	p.L185L	GBP6_ENST00000535065.1_Silent_p.L55L	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	185							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ATTTCACTCTGGAGCTGAAGT	0.483000													31	102					0	0	1	0	0
B3GALT4	8705	broad.mit.edu	37	6	33246057	33246057	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33246057C>T	ENST00000451237.1	+	1	1141	c.861C>T	c.(859-861)ctC>ctT	p.L287L		NM_003782.3	NP_003773.1	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	287					protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	13						CACCCCTTCTCCCATTAGAGG	0.627000													25	57					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56934979	56934979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56934979C>T	ENST00000333201.9	+	5	1162	c.952C>T	c.(952-954)Cat>Tat	p.H318Y	ZNF583_ENST00000585612.1_3'UTR|ZNF583_ENST00000291598.7_Missense_Mutation_p.H318Y	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		TCAGAGAGTTCATACTGGAGA	0.413000													18	133					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24447200	24447200	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24447200C>T	ENST00000230036.1	-	18	1796	c.1686G>A	c.(1684-1686)ctG>ctA	p.L562L		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	562						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						CCTCCACGTTCAGTTTTTCTA	0.453000													24	72					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149263071	149263071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149263071C>T	ENST00000255266.5	-	17	2175	c.2056G>A	c.(2056-2058)Gat>Aat	p.D686N		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	686					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TTAGACTGATCCACGATCTTT	0.443000													5	55					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8637897	8637897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:8637897C>T	ENST00000378641.3	+	8	1136	c.661C>T	c.(661-663)Cct>Tct	p.P221S	PLCB1_ENST00000378637.2_Missense_Mutation_p.P221S|PLCB1_ENST00000338037.6_Missense_Mutation_p.P221S	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	221				P -> L (in Ref. 2; AAF86613).	activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CAACCTTTGCCCTCGACCTGA	0.393000													15	131					0	0	1	0	0
NHLH2	4808	broad.mit.edu	37	1	116380921	116380921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:116380921C>T	ENST00000369506.1	-	1	5617	c.73G>A	c.(73-75)Ggc>Agc	p.G25S	NHLH2_ENST00000320238.3_Missense_Mutation_p.G25S			Q02577	HEN2_HUMAN	nescient helix loop helix 2	25					cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			prostate(1)	1	Lung SC(450;0.184)	all_cancers(81;1.75e-06)|all_epithelial(167;1.16e-06)|all_lung(203;9.55e-06)|Lung NSC(69;5.83e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TCCGTGCCGCCCAGGGACTCC	0.677000													7	20					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18745386	18745386	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18745386C>T	ENST00000304081.4	-	9	1430		c.e9-1		NT5C1B-RDH14_ENST00000532967.1_Splice_Site|NT5C1B_ENST00000600945.1_Splice_Site|NT5C1B_ENST00000359846.2_Splice_Site	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TTAGGGGACCCTGTAAAAGGA	0.388000													26	81					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217279704	217279704	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:217279704C>T	ENST00000357276.4	+	3	607	c.277C>T	c.(277-279)Cag>Tag	p.Q93*	SMARCAL1_ENST00000358207.5_Nonsense_Mutation_p.Q93*	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	93					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCACAGTTTTCAGGCAAAGGG	0.483000									Schimke Immuno-Osseous Dysplasia				20	46					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26695000	26695000	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26695000C>T	ENST00000396005.3	-	14	1965	c.1656G>A	c.(1654-1656)aaG>aaA	p.K552K		NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	552					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GTGTTTTGTACTTCTTAGACC	0.383000													59	140					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1189698	1189698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:1189698G>A	ENST00000446702.2	+	2	633	c.6G>A	c.(4-6)agG>agA	p.R2R	CNTN6_ENST00000539053.1_Intron|CNTN6_ENST00000350110.2_Silent_p.R2R			Q9UQ52	CNTN6_HUMAN	contactin 6	2					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TGGAAATGAGGTTGCTATGGA	0.348000													16	134					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75111623	75111623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75111623C>T	ENST00000379709.3	+	6	730	c.728C>T	c.(727-729)cCc>cTc	p.P243L	LMAN1L_ENST00000309664.5_Intron			Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	255	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGTGAGGATCCCACTGGACAG	0.572000													43	165					0	0	1	0	0
SLAIN1	122060	broad.mit.edu	37	13	78335025	78335025	+	Nonsense_Mutation	SNP	C	C	T	rs142633526		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:78335025C>T	ENST00000466548.1	+	7	1437	c.1411C>T	c.(1411-1413)Cga>Tga	p.R471*	SLAIN1_ENST00000314070.5_Nonsense_Mutation_p.R94*|SLAIN1_ENST00000358679.3_Nonsense_Mutation_p.R208*|SLAIN1_ENST00000351546.3_Nonsense_Mutation_p.R208*|SLAIN1_ENST00000488699.1_Nonsense_Mutation_p.R329*|SLAIN1_ENST00000418532.1_Nonsense_Mutation_p.R252*|SLAIN1_ENST00000267219.8_Nonsense_Mutation_p.R252*	NM_001242868.1	NP_001229797.1	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1	471								p.R252*(1)		breast(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		AGTGTCTATCCGACAGCCTCT	0.478000													37	109					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992447	85992447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85992447C>T	ENST00000372105.3	-	4	1129	c.1108G>A	c.(1108-1110)Gaa>Aaa	p.E370K		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	370						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GCAGCAGCTTCCCCTCCGCCA	0.577000													6	16					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760570	19760570	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19760570G>A	ENST00000357324.6	-	18	2541	c.2515C>T	c.(2515-2517)Cgt>Tgt	p.R839C	ATP13A1_ENST00000291503.5_Missense_Mutation_p.R721C	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	839					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGAGCCACACGGGCGAACACC	0.672000													19	56					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10243554	10243554	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10243554C>T	ENST00000418404.3	-	17	2132	c.1968_splice	c.e17-1	p.E657_splice	MYH13_ENST00000570743.1_Splice_Site_p.E657_splice|RP11-401O9.3_ENST00000577743.1_RNA|MYH13_ENST00000252172.4_Splice_Site_p.E657_splice			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	657	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TTTAAATTTTCCTGGGACATA	0.433000													16	18					0	0	1	0	0
SCP2D1	140856	broad.mit.edu	37	20	18794508	18794508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:18794508C>T	ENST00000377428.2	+	1	139	c.49C>T	c.(49-51)Cct>Tct	p.P17S	C20orf78_ENST00000278779.4_Intron	NM_178483.2	NP_848578.1			SCP2 sterol-binding domain containing 1																		AGAGGATGGACCTCTGGTGGG	0.522000													11	49					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155157067	155157067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155157067C>T	ENST00000357232.3	-	25	7371	c.7372G>A	c.(7372-7374)Gga>Aga	p.G2458R		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2458	Cadherin 22.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGAATGACTCCATCAATACCA	0.378000													43	108					0	0	1	0	0
PARM1	25849	broad.mit.edu	37	4	75937790	75937790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:75937790C>T	ENST00000307428.7	+	2	411	c.199C>T	c.(199-201)Cca>Tca	p.P67S	RP11-44F21.2_ENST00000513770.1_RNA|PARM1_ENST00000513238.1_Intron	NM_015393.3	NP_056208.2	Q6UWI2	PARM1_HUMAN	prostate androgen-regulated mucin-like protein 1	67					positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						CTCGGTGCTCCCAGTTACAGC	0.517000													19	72					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176520672	176520672	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176520672C>G	ENST00000292408.4	+	11	1660	c.1415C>G	c.(1414-1416)cCc>cGc	p.P472R	FGFR4_ENST00000393648.2_Missense_Mutation_p.P404R|FGFR4_ENST00000393637.1_Missense_Mutation_p.P432R|FGFR4_ENST00000502906.1_Missense_Mutation_p.P472R|FGFR4_ENST00000292410.3_Missense_Mutation_p.P432R	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	472	Protein kinase.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CTTGGGAAGCCCCTAGGCGAG	0.667000										TSP Lung(9;0.080)			14	56					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	131781525	131781525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:131781525G>A	ENST00000374786.1	+	1	629	c.150G>A	c.(148-150)ggG>ggA	p.G50G	NTM_ENST00000374791.3_Silent_p.G50G|NTM_ENST00000539799.1_Silent_p.G50G|NTM_ENST00000427481.2_Silent_p.G41G|NTM_ENST00000374784.1_Silent_p.G50G|NTM_ENST00000425719.2_Silent_p.G50G	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	50	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						TCCGGCAGGGGGAGAGCGCCA	0.612000											OREG0021537	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	89					0	0	1	0	0
USP19	10869	broad.mit.edu	37	3	49146461	49146461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49146461G>A	ENST00000434032.2	-	27	4401	c.4190C>T	c.(4189-4191)aCc>aTc	p.T1397I	USP19_ENST00000453664.1_Intron|USP19_ENST00000398888.2_Missense_Mutation_p.T1296I|USP19_ENST00000398898.2_Intron|USP19_ENST00000398892.3_Missense_Mutation_p.T1336I|USP19_ENST00000417901.1_Intron|USP19_ENST00000398896.1_Intron	NM_001199160.1	NP_001186089.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	1296					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGCCGCCACGGTGCCCAGGAC	0.662000													4	17					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75072303	75072303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75072303C>T	ENST00000326665.5	-	10	1689	c.1471G>A	c.(1471-1473)Gaa>Aaa	p.E491K	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.E294K	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	491	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AAAGTATTTTCCTGGTCGTCT	0.358000													12	181					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6623959	6623959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6623959C>T	ENST00000315579.5	+	9	1659	c.860C>T	c.(859-861)cCc>cTc	p.P287L	NCAPD2_ENST00000545962.1_Missense_Mutation_p.P242L	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	287	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						CAAAAGTGTCCCCAAGAGCTG	0.478000													23	71					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35616947	35616947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:35616947C>T	ENST00000287272.2	+	13	2086	c.2066C>T	c.(2065-2067)cCc>cTc	p.P689L	UNC5D_ENST00000416672.1_Missense_Mutation_p.P763L|UNC5D_ENST00000420357.1_Missense_Mutation_p.P691L|UNC5D_ENST00000449677.1_Missense_Mutation_p.P334L|UNC5D_ENST00000404895.2_Missense_Mutation_p.P758L|UNC5D_ENST00000453357.2_Missense_Mutation_p.P753L			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	758					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTTGATATTCCCCCATTCCTC	0.448000													39	155					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53269757	53269757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53269757C>T	ENST00000338230.3	-	3	1519	c.1252G>A	c.(1252-1254)Gaa>Aaa	p.E418K		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		TTCCCACATTCATTACACTTG	0.358000													27	121					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178418886	178418886	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178418886G>A	ENST00000231188.5	-	2	881	c.703C>T	c.(703-705)Cag>Tag	p.Q235*	GRM6_ENST00000517717.1_Nonsense_Mutation_p.Q235*	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	235					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CGGGAGATCTGAACGAAGGCC	0.617000													11	26					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	66980196	66980196	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66980196C>T	ENST00000340001.4	-	35	4711		c.e35+1		ABCA9_ENST00000453985.2_Splice_Site|ABCA9_ENST00000370732.2_Splice_Site	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9						transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					CAGGCACTCACCTCAGCCTTC	0.592000													45	80					0	0	1	0	0
PPP1CA	5499	broad.mit.edu	37	11	67166500	67166500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67166500C>T	ENST00000376745.4	-	5	806	c.658G>A	c.(658-660)Gac>Aac	p.D220N	PPP1CA_ENST00000358239.4_Missense_Mutation_p.D176N|PPP1CA_ENST00000312989.7_Missense_Mutation_p.D231N|PPP1CA_ENST00000532446.1_5'UTR	NM_001008709.1|NM_002708.3	NP_001008709.1|NP_002699.1	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha isozyme	220					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			ACGCCACGGTCGTTCTCGCCC	0.627000													23	86					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528889	20528889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20528889C>T	ENST00000315683.1	+	1	686	c.686C>T	c.(685-687)tCa>tTa	p.S229L		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		CCAAAAAAATCATCACATGGG	0.438000													49	133					0	0	1	0	0
CHSY1	22856	broad.mit.edu	37	15	101718571	101718571	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101718571G>A	ENST00000254190.3	-	3	1906	c.1431C>T	c.(1429-1431)ttC>ttT	p.F477F	CHSY1_ENST00000543813.1_5'UTR	NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	477					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGATTTTGCTGAAAGTCTGCT	0.488000													40	33					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84559348	84559348	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84559348C>T	ENST00000262753.4	-	14	1712		c.e14+1		POF1B_ENST00000373145.3_Splice_Site	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B								actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TCCTTTTATACCTCTGACTGA	0.403000													26	43					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8375235	8375235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8375235G>A	ENST00000538603.1	-	7	1136	c.578C>T	c.(577-579)tCc>tTc	p.S193F	FAM90A1_ENST00000307435.6_Missense_Mutation_p.S193F	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	193							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		ACTTGAGGAGGAGCTCAGACT	0.597000													23	90					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71150068	71150068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71150068C>T	ENST00000355527.3	-	7	964	c.688G>A	c.(688-690)Ggg>Agg	p.G230R	DHCR7_ENST00000407721.2_Missense_Mutation_p.G230R	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	230					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	AACCACTTCCCGATCCGAGGG	0.473000									Smith-Lemli-Opitz syndrome				21	50					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133895173	133895173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133895173C>T	ENST00000220616.4	+	8	1044	c.1004C>T	c.(1003-1005)cCc>cTc	p.P335L	TG_ENST00000377869.1_Missense_Mutation_p.P335L	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	335	Thyroglobulin type-1 4.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ACGGAAGGGCCCTGCTGGTGT	0.607000													19	32					0	0	1	0	0
EPHX2	2053	broad.mit.edu	37	8	27348760	27348760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27348760G>A	ENST00000521400.1	+	1	465	c.35G>A	c.(34-36)gGg>gAg	p.G12E	EPHX2_ENST00000380476.3_5'UTR|EPHX2_ENST00000521780.1_5'UTR|EPHX2_ENST00000517536.1_Missense_Mutation_p.G12E|EPHX2_ENST00000518379.1_Missense_Mutation_p.G12E|EPHX2_ENST00000520666.1_3'UTR	NM_001979.5	NP_001970.2	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	12	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	27		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GACCTTGACGGGGTGCTGGCG	0.741000													5	8					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335524	20335524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20335524G>A	ENST00000302555.5	-	3	298	c.149C>T	c.(148-150)gCt>gTt	p.A50V	GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.A50V|GP2_ENST00000341642.5_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	50						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GGTGCCAGGAGCTCCGCAGTC	0.547000													12	57					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699764	48699764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48699764G>A	ENST00000544264.1	-	1	584	c.304C>T	c.(304-306)Cct>Tct	p.P102S	CELSR3_ENST00000164024.4_Missense_Mutation_p.P102S			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	102					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCTGCTCAGGGGGCCCTCGA	0.657000													65	160					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83129493	83129493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:83129493G>A	ENST00000329312.4	+	4	1814	c.1777G>A	c.(1777-1779)Gaa>Aaa	p.E593K		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	593					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TGAAAAAGGGGAAAAAGCAAG	0.423000													26	21					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46607818	46607818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:46607818C>T	ENST00000263734.3	+	12	2517	c.2007C>T	c.(2005-2007)ccC>ccT	p.P669P		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	669					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CGTTGGGGCCCCCTGTCTCTC	0.587000													45	118					0	0	1	0	0
SPATA8	145946	broad.mit.edu	37	15	97327486	97327486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:97327486G>A	ENST00000328504.3	+	2	460	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	SPATA8_ENST00000558553.1_Missense_Mutation_p.G24E	NM_173499.3	NP_775770.1	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	65										large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			GCCTGCAAAGGAAGGTAAGTA	0.577000													15	76					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22892266	22892266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22892266C>T	ENST00000543184.1	-	4	1697	c.835G>A	c.(835-837)Gag>Aag	p.E279K	PRAME_ENST00000402697.1_Missense_Mutation_p.E279K|PRAME_ENST00000539862.1_Missense_Mutation_p.E263K|PRAME_ENST00000405655.3_Missense_Mutation_p.E279K|PRAME_ENST00000424204.2_Missense_Mutation_p.E263K|PRAME_ENST00000398743.2_Missense_Mutation_p.E279K|PRAME_ENST00000398741.1_Missense_Mutation_p.E279K	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	279					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		TCTTCCTTCTCCGGGGAAATG	0.507000													34	81					0	0	1	0	0
CLLU1	574028	broad.mit.edu	37	12	92818597	92818597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:92818597G>A	ENST00000378485.1	+	1	863	c.141G>A	c.(139-141)ctG>ctA	p.L47L	CLLU1OS_ENST00000538965.1_Intron|RP11-693J15.4_ENST00000508671.1_RNA|CLLU1OS_ENST00000378487.2_Intron|CLLU1_ENST00000472839.2_Intron	NM_001025233.1	NP_001020404.1			chronic lymphocytic leukemia up-regulated 1											NS(1)|breast(1)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	7						TAAATAAGCTGATTATTTATT	0.313000													13	35					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79387423	79387423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:79387423C>T	ENST00000370742.3	-	9	1195	c.1132G>A	c.(1132-1134)Gat>Aat	p.D378N		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	378	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTCATGGTATCAGGTGAGTAA	0.403000													14	99					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1616936	1616936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1616936C>T	ENST00000381580.1	-	3	726	c.547G>A	c.(547-549)Gac>Aac	p.D183N	SIRPG_ENST00000216927.4_Missense_Mutation_p.D216N|SIRPG_ENST00000303415.3_Missense_Mutation_p.D216N|RP11-77C3.3_ENST00000456177.1_RNA|SIRPG_ENST00000344103.4_Intron|SIRPG_ENST00000381583.2_Missense_Mutation_p.D216N			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	216	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						TCCCAGGGGTCCAGTACCACC	0.597000													34	86					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172479429	172479429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172479429G>A	ENST00000417960.1	+	8	1095	c.618G>A	c.(616-618)atG>atA	p.M206I	ECT2_ENST00000540509.1_Missense_Mutation_p.M238I|ECT2_ENST00000232458.5_Missense_Mutation_p.M207I|ECT2_ENST00000441497.2_Missense_Mutation_p.M207I|ECT2_ENST00000427830.1_Missense_Mutation_p.M207I|ECT2_ENST00000392692.3_Missense_Mutation_p.M238I	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	207	BRCT 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CTCCAATTATGAAGCCAGAAT	0.323000													38	93					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180569	124180569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124180569G>A	ENST00000357821.2	-	1	164	c.94C>T	c.(94-96)Ctg>Ttg	p.L32L		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TAGATTCCCAGGAACAGGAGG	0.483000													18	137					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51382663	51382663	+	Silent	SNP	G	G	A	rs151022264		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51382663G>A	ENST00000216392.7	-	10	1451	c.1119C>T	c.(1117-1119)ttC>ttT	p.F373F	PYGL_ENST00000532462.1_Silent_p.F373F|PYGL_ENST00000544180.2_Silent_p.F339F	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	373					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TGGTGTAGGCGAAGGTCTTCT	0.592000													11	60					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76811167	76811167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76811167G>A	ENST00000286719.7	-	5	716	c.360C>T	c.(358-360)tcC>tcT	p.S120S		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	120			S -> R.		detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GGAGTGGGAAGGAGAGGCGTG	0.522000													53	145					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269763	150269763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150269763G>A	ENST00000255945.2	+	3	780	c.605G>A	c.(604-606)aGg>aAg	p.R202K	GIMAP4_ENST00000461940.1_Missense_Mutation_p.R216K|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	202							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAGGCCCAGAGGGCACAGTTG	0.547000													27	97					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1634338	1634338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1634338G>A	ENST00000426508.2	-	11	1602	c.1239C>T	c.(1237-1239)ttC>ttT	p.F413F	LA16c-395F10.2_ENST00000563162.1_RNA|IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	413										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				CTTGCTGGTGGAAGTGTGACG	0.607000													6	13					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39525587	39525587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39525587G>A	ENST00000265707.5	+	14	1442	c.1397G>A	c.(1396-1398)gGa>gAa	p.G466E	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.G442E	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	466	Disintegrin.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TACTGCAATGGAACCTCTAGT	0.393000													61	125					0	0	1	0	0
TMEFF2	23671	broad.mit.edu	37	2	193059173	193059173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:193059173G>A	ENST00000409056.3	-	1	77	c.78C>T	c.(76-78)ccC>ccT	p.P26P	TMEFF2_ENST00000392314.1_Silent_p.P26P|TMEFF2_ENST00000272771.5_Silent_p.P26P			Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two follistatin-like domains 2	26						extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			GTAGCATGACGGGCAGCAGCA	0.597000													27	72					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46096167	46096167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46096167C>T	ENST00000252934.5	+	4	662	c.397C>T	c.(397-399)Cgc>Tgc	p.R133C	ATXN10_ENST00000498009.1_3'UTR|ATXN10_ENST00000381061.4_Missense_Mutation_p.R69C	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	133					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		CTTAGCTTTTCGCTGTGGCCT	0.313000													15	32					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	336800	336800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:336800G>A	ENST00000343164.4	-	8	918	c.866C>T	c.(865-867)tCc>tTc	p.S289F	SLC6A13_ENST00000445055.2_Missense_Mutation_p.S197F	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	289					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GATGGCGAAGGAGAAGAATAT	0.567000													17	36					0	0	1	0	0
UBL4B	164153	broad.mit.edu	37	1	110655414	110655414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110655414G>A	ENST00000334179.3	+	1	353	c.258G>A	c.(256-258)caG>caA	p.Q86Q		NM_203412.1	NP_981957.1	Q8N7F7	UBL4B_HUMAN	ubiquitin-like 4B	86						cytoplasm				endometrium(1)|kidney(1)|large_intestine(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	7		all_cancers(81;1.14e-05)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0236)|all cancers(265;0.0823)|Epithelial(280;0.0917)|Colorectal(144;0.109)|LUSC - Lung squamous cell carcinoma(189;0.134)		ACCAGCCGCAGACCCAGCCCC	0.582000													21	110					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103126831	103126831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103126831G>A	ENST00000428762.1	-	61	9955	c.9796C>T	c.(9796-9798)Ccc>Tcc	p.P3266S	CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000343529.5_Missense_Mutation_p.P3266S|RELN_ENST00000424685.2_Missense_Mutation_p.P3266S	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3266					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATATAACTGGGAAGGTCGTGA	0.463000													23	53					0	0	1	0	0
S100Z	170591	broad.mit.edu	37	5	76173582	76173582	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76173582C>T	ENST00000317593.4	+	4	457	c.225C>T	c.(223-225)ttC>ttT	p.F75F	S100Z_ENST00000513010.1_Silent_p.F75F	NM_130772.3	NP_570128.2	Q8WXG8	S100Z_HUMAN	S100 calcium binding protein Z	75	EF-hand 2.						calcium ion binding			large_intestine(1)|ovary(1)	2		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;8.91e-51)|Epithelial(54;5.43e-45)|all cancers(79;1.82e-40)		TTAATGAATTCGTGGTCATGG	0.378000													7	75					0	0	1	0	0
HBM	3042	broad.mit.edu	37	16	216426	216426	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:216426G>A	ENST00000356815.3	+	2	272	c.252G>A	c.(250-252)gcG>gcA	p.A84A	HBM_ENST00000472539.1_3'UTR	NM_001003938.3	NP_001003938.1	Q6B0K9	HBM_HUMAN	hemoglobin, mu	84						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity						all_cancers(16;1.62e-06)|all_epithelial(16;4.01e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				GCCCGCTGGCGGACCTGCACG	0.746000													4	7					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28996799	28996799	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:28996799C>T	ENST00000322982.3	-	0	1135							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GCTGGCTCAGCCGATTACCCT	0.692000													3	16					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28649024	28649024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28649024C>T	ENST00000280904.6	-	15	2787	c.2344G>A	c.(2344-2346)Gag>Aag	p.E782K	DSC2_ENST00000251081.6_Missense_Mutation_p.E782K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	782					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCGATGGTCTCCTGACCTCCG	0.567000													23	48					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18869133	18869133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18869133G>A	ENST00000406451.3	+	19	2569	c.2419G>A	c.(2419-2421)Gac>Aac	p.D807N	HDAC9_ENST00000441542.2_Missense_Mutation_p.D810N|HDAC9_ENST00000432645.2_Missense_Mutation_p.D807N|HDAC9_ENST00000401921.1_Missense_Mutation_p.D766N	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	807	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	ATACTTGAGAGACCAACTAAA	0.378000													26	48					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57611049	57611049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57611049G>A	ENST00000371236.2	-	3	384	c.121C>T	c.(121-123)Cgg>Tgg	p.R41W	DAB1_ENST00000371231.1_Missense_Mutation_p.R41W|DAB1_ENST00000439789.2_Missense_Mutation_p.R41W|DAB1_ENST00000371234.4_Missense_Mutation_p.R41W|DAB1_ENST00000420954.2_Missense_Mutation_p.R41W|DAB1_ENST00000371230.1_Missense_Mutation_p.R41W|DAB1_ENST00000414851.2_Missense_Mutation_p.R41W|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	41	PID.				cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCTTTGTACCGGACCCCTTCA	0.443000													36	99					0	0	1	0	0
SFXN2	118980	broad.mit.edu	37	10	104495636	104495636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104495636C>T	ENST00000369893.4	+	11	1006	c.839C>T	c.(838-840)cCa>cTa	p.P280L		NM_178858.4	NP_849189.1	Q96NB2	SFXN2_HUMAN	sideroflexin 2	280					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|prostate(1)	13		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		TTCATGGTGCCAGTGGCGTGT	0.542000													11	130					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124739717	124739717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124739717G>A	ENST00000311127.4	-	4	1238	c.1171C>T	c.(1171-1173)Cca>Tca	p.P391S		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	391						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						TCATCCCCTGGATTCCCAGTT	0.448000													19	52					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107267485	107267485	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107267485C>T	ENST00000334726.2	+	1	1031	c.942C>T	c.(940-942)ttC>ttT	p.F314F		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATACTGCCTTCATTTCCATCC	0.338000													17	52					0	0	1	0	0
PRNT	149830	broad.mit.edu	37	20	4713310	4713310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:4713310G>A	ENST00000326539.2	-	2	950	c.13C>T	c.(13-15)Ctt>Ttt	p.L5F	PRNT_ENST00000423718.2_Missense_Mutation_p.L5F|PRNT_ENST00000418528.1_Missense_Mutation_p.L5F														p.L5F(2)		endometrium(2)|lung(5)	7						aagaaaacaagactatgctgc	0.488000													6	12					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55432786	55432786	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55432786C>T	ENST00000314259.3	+	1	173	c.144C>T	c.(142-144)atC>atT	p.I48I		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TAACTATTATCACAAGTCAGA	0.408000													23	219					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70355236	70355236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70355236G>A	ENST00000305107.6	-	3	969	c.923C>T	c.(922-924)tCt>tTt	p.S308F	UGT2B4_ENST00000381096.3_Missense_Mutation_p.S172F|UGT2B4_ENST00000512583.1_Missense_Mutation_p.S308F|UGT2B4_ENST00000506580.1_5'UTR	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	308					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						CGACCCCAGAGAAAACACCAC	0.393000													83	209					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130286178	130286178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130286178G>A	ENST00000257359.6	-	4	1850	c.1144C>T	c.(1144-1146)Ctc>Ttc	p.L382F		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	382	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GGCCCGAAGAGCCGTGTGCAG	0.672000													3	6					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404038	20404038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20404038C>T	ENST00000285600.4	+	1	272	c.213C>T	c.(211-213)atC>atT	p.I71I		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TCATTGATATCTGTCAGTCTA	0.393000													53	127					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156937867	156937867	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156937867G>A	ENST00000368194.3	-	11	1914	c.875C>T	c.(874-876)cCt>cTt	p.P292L	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.P252L	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	252					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGAGGTTCGAGGACTGTCTAG	0.567000													30	31					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143018840	143018840	+	Missense_Mutation	SNP	C	C	T	rs143506735		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143018840C>T	ENST00000343257.2	+	5	682	c.595C>T	c.(595-597)Cgt>Tgt	p.R199C	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	199					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GACAATACTTCGTGGGGTTGT	0.507000													21	58					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784745	30784745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30784745G>A	ENST00000246229.4	-	3	1265	c.1001C>T	c.(1000-1002)tCc>tTc	p.S334F		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	334						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTGAGCTGGGGAAGAGATAGG	0.557000													14	143					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922597	24922597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922597C>T	ENST00000329468.2	+	1	2057	c.1583C>T	c.(1582-1584)tCc>tTc	p.S528F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCTCCTCTTTCCTTCCTGACT	0.532000													81	213					0	0	1	0	0
GTPBP10	85865	broad.mit.edu	37	7	90007497	90007497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:90007497C>T	ENST00000222511.6	+	8	815	c.749C>T	c.(748-750)gCt>gTt	p.A250V	GTPBP10_ENST00000257659.8_Missense_Mutation_p.A171V	NM_033107.3	NP_149098.2	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 (putative)	250					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(4)	10						TACAGGACAGCTTTTGAAACC	0.323000													19	34					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38775237	38775237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:38775237C>T	ENST00000308973.4	-	4	2580	c.1975G>A	c.(1975-1977)Gaa>Aaa	p.E659K	TLR10_ENST00000506111.1_Missense_Mutation_p.E659K|TLR10_ENST00000508334.1_Missense_Mutation_p.E659K|TLR10_ENST00000361424.2_Missense_Mutation_p.E659K	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	659	TIR.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						GAACCATCTTCCTTCTCTAGA	0.368000													26	71					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23080766	23080766	+	Missense_Mutation	SNP	G	G	A	rs138556206		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23080766G>A	ENST00000219689.7	-	16	2659	c.2660C>T	c.(2659-2661)tCg>tTg	p.S887L	USP31_ENST00000567975.1_Missense_Mutation_p.S180L	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	887	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GTGAATTGGCGAATCCCCTGA	0.517000													4	33					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58598338	58598338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58598338C>T	ENST00000240727.6	-	5	1079	c.680G>A	c.(679-681)gGg>gAg	p.G227E	ZSCAN18_ENST00000421612.2_Missense_Mutation_p.G92E|ZSCAN18_ENST00000601144.1_Missense_Mutation_p.G227E|ZSCAN18_ENST00000600404.1_Missense_Mutation_p.G283E	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	227					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCCCCACTCCCCCAGGTGCTG	0.642000													10	48					0	0	1	0	0
CHST13	166012	broad.mit.edu	37	3	126261247	126261247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126261247C>T	ENST00000319340.2	+	3	902	c.852C>T	c.(850-852)tcC>tcT	p.S284S		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	284					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		CGGGCGCATCCGACCTGAGCT	0.746000													5	7					0	0	1	0	0
SPACA1	81833	broad.mit.edu	37	6	88769219	88769219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88769219G>A	ENST00000237201.1	+	5	640	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K	SPACA1_ENST00000462690.1_3'UTR	NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	175						integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		AGTACGCAAGGAAAGTCACCC	0.343000													9	44					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78432425	78432425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:78432425G>A	ENST00000370767.1	-	7	513	c.426C>T	c.(424-426)ggC>ggT	p.G142G	FUBP1_ENST00000436586.2_Silent_p.G163G|FUBP1_ENST00000370768.2_Silent_p.G142G			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	142	KH 1.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						TTTCTGGAAGGCCACCACTGT	0.323000			"""F, N"""		oligodendroglioma								20	43					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1235690	1235690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1235690C>T	ENST00000324642.3	+	4	657	c.534C>T	c.(532-534)tcC>tcT	p.S178S	SLC6A18_ENST00000296821.4_Silent_p.S178S	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	178					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACAGTGGCTCCATCCAGTGGT	0.572000													40	95					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43777406	43777406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43777406C>T	ENST00000389420.3	-	31	4751	c.4752G>A	c.(4750-4752)agG>agA	p.R1584R		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1584	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAGGAGGGTTCCTGCAATTCT	0.378000													7	29					0	0	1	0	0
BNIP3P1	319138	broad.mit.edu	37	14	28733809	28733809	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:28733809C>T	ENST00000550043.1	+	0	214																											CTGCAGGGCTCCTGGGTAGAA	0.587000													5	36					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77415293	77415293	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77415293C>T	ENST00000451710.3	-	17	2352	c.2115G>A	c.(2113-2115)tcG>tcA	p.S705S	TRPM6_ENST00000376864.4_Silent_p.S705S|TRPM6_ENST00000449912.2_Silent_p.S700S|TRPM6_ENST00000360774.1_Silent_p.S705S|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Silent_p.S700S|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	705					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TAAGGCAGGTCGAATTGCTCC	0.512000													20	59					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60886272	60886272	+	Missense_Mutation	SNP	C	C	T	rs112963711	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60886272C>T	ENST00000252999.3	-	73	10100	c.10034G>A	c.(10033-10035)gGt>gAt	p.G3345D		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3345	Laminin G-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACAGGGAACCCCCAAACTG	0.701000													14	52					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111769563	111769563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111769563G>A	ENST00000452346.2	+	9	1139	c.1136G>A	c.(1135-1137)gGg>gAg	p.G379E	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.G253E			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	379	CUB 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GGCTTTGAAGGGAAAATTTCA	0.403000													79	213					0	0	1	0	0
CSAD	51380	broad.mit.edu	37	12	53552405	53552405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53552405G>A	ENST00000267085.4	-	17	1686	c.1453C>T	c.(1453-1455)Cac>Tac	p.H485Y	CSAD_ENST00000444623.1_Missense_Mutation_p.H458Y|CSAD_ENST00000379846.1_Missense_Mutation_p.H311Y|CSAD_ENST00000379843.3_Missense_Mutation_p.H311Y|CSAD_ENST00000453446.2_Missense_Mutation_p.H458Y	NM_001244706.1|NM_015989.4	NP_001231635.1|NP_057073.4	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	458					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(4)	14					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CGGGTCCCGTGGGGCTGGTAG	0.612000													9	28					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65621788	65621788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65621788C>T	ENST00000327987.4	-	13	2396	c.2145G>A	c.(2143-2145)aaG>aaA	p.K715K		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	715										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GCTCCAGCTCCTTCATATCCA	0.657000													88	130					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41161795	41161795	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41161795C>T	ENST00000263413.3	-	10	1722	c.1458_splice	c.e10+1	p.E486_splice	C6_ENST00000337836.5_Splice_Site_p.E486_splice|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	486	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTACTCTTACCTCAAAGTCAA	0.398000													25	92					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229372	140229372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140229372G>A	ENST00000378122.3	+	1	2016	c.1292G>A	c.(1291-1293)gGc>gAc	p.G431D	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.G431D|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGACGGGGGCTCGCCTTCA	0.632000													14	87					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995875	19995875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:19995875C>T	ENST00000391403.2	-	1	2003	c.1900G>A	c.(1900-1902)Gat>Aat	p.D634N		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	634						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TCTTTGGTATCATTTCTACTG	0.433000													88	229					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40254023	40254023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40254023C>T	ENST00000263791.5	+	7	825	c.782C>T	c.(781-783)tCt>tTt	p.S261F	EIF2AK4_ENST00000559624.1_Missense_Mutation_p.S261F|EIF2AK4_ENST00000382727.2_Missense_Mutation_p.S261F	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	261					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGTGAAGATTCTCCTGGCTCT	0.323000													31	75					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25718530	25718530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:25718530C>T	ENST00000349320.3	-	6	929	c.541G>A	c.(541-543)Gat>Aat	p.D181N	RHCE_ENST00000413854.1_Missense_Mutation_p.D197N|RHCE_ENST00000425135.1_Missense_Mutation_p.D197N|RHCE_ENST00000243186.6_Missense_Mutation_p.D197N|RHCE_ENST00000340849.4_Intron|RHCE_ENST00000349438.4_Missense_Mutation_p.D197N|RHCE_ENST00000294413.7_Missense_Mutation_p.D197N|RHCE_ENST00000346452.4_Intron|RHCE_ENST00000455194.1_Intron|RHCE_ENST00000374352.2_Missense_Mutation_p.D181N			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	197						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		TGATCATTATCCTCCGTTCCC	0.537000													39	104					0	0	1	0	0
HOOK1	51361	broad.mit.edu	37	1	60330893	60330893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60330893C>T	ENST00000371208.3	+	18	1977	c.1720C>T	c.(1720-1722)Ctt>Ttt	p.L574F	HOOK1_ENST00000395561.2_Missense_Mutation_p.L532F|HOOK1_ENST00000465876.1_Intron	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1	574					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					CATTGAAGATCTTCAGCCAGA	0.373000													19	60					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113549986	113549986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113549986C>T	ENST00000416899.2	+	12	1897	c.1771C>T	c.(1771-1773)Ccc>Tcc	p.P591S	MUSK_ENST00000189978.5_Missense_Mutation_p.P599S|MUSK_ENST00000374438.1_Missense_Mutation_p.P115S|MUSK_ENST00000374448.4_Missense_Mutation_p.P599S			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	599	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						AGGCTTACTTCCCTATGAACC	0.443000													9	23					0	0	1	0	0
TARSL2	123283	broad.mit.edu	37	15	102241367	102241367	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:102241367G>A	ENST00000335968.3	-	10	1458	c.1242C>T	c.(1240-1242)ttC>ttT	p.F414F		NM_152334.2	NP_689547.2	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	414					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|skin(1)|urinary_tract(1)	29	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCAAATCGTGGAAAAAGAAAA	0.323000													46	51					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	12989982	12989982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:12989982G>A	ENST00000399002.2	+	1	341	c.67G>A	c.(67-69)Ggc>Agc	p.G23S	SPTLC3_ENST00000476791.1_3'UTR|SPTLC3_ENST00000378194.4_Missense_Mutation_p.G23S	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	23					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	ACAGAGCAATGGCTCACAAAG	0.483000													17	85					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83023654	83023654	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83023654C>T	ENST00000307792.3	-	13	1926	c.1458_splice	c.e13-1	p.D487_splice	SEMA3E_ENST00000427262.1_Splice_Site_p.D427_splice	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	487	Sema.				axon guidance	extracellular space|membrane	receptor activity	p.D487Y(1)		breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GGAACTGGATCCTGAAATTTT	0.318000													16	38					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89157152	89157152	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89157152C>T	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA|IGKC_ENST00000390237.2_RNA																							TTCAACTGCTCATCAGATGGC	0.488000													6	12					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113512583	113512583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113512583C>T	ENST00000487903.1	+	22	2734	c.2646C>T	c.(2644-2646)ctC>ctT	p.L882L	ATP11A_ENST00000375645.3_Silent_p.L882L|ATP11A_ENST00000283558.8_Silent_p.L882L|ATP11A_ENST00000375630.2_Silent_p.L882L			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	882					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCTCTGAGCTCGTGCAGTACT	0.507000													12	55					0	0	1	0	0
BEND2	139105	broad.mit.edu	37	X	18192171	18192171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:18192171C>T	ENST00000380033.4	-	12	2092	c.1960G>A	c.(1960-1962)Gag>Aag	p.E654K	BEND2_ENST00000380030.3_Missense_Mutation_p.E563K	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	654										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						CCAGGTTCCTCTGGATTATCA	0.378000													20	13					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7677065	7677065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7677065G>A	ENST00000446248.2	+	13	1868	c.1767G>A	c.(1765-1767)gtG>gtA	p.V589V	CAMSAP3_ENST00000160298.4_Silent_p.V562V	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	562					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						ACTCCGAGGTGAAAATGACCA	0.672000													7	13					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67912443	67912443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67912443C>T	ENST00000358933.5	+	10	1332	c.1093C>T	c.(1093-1095)Cct>Tct	p.P365S	EDC4_ENST00000574770.1_3'UTR	NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	365					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TTGCAGTGTCCCTTTCTGGAG	0.562000													35	84					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115168320	115168320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115168320C>T	ENST00000393274.1	-	4	911	c.286G>A	c.(286-288)Gaa>Aaa	p.E96K	DENND2C_ENST00000393276.3_Missense_Mutation_p.E96K|DENND2C_ENST00000393277.1_Missense_Mutation_p.E96K	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	96										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCTTATTTTCATTCTCACTT	0.343000													35	98					0	0	1	0	0
C10orf137	26098	broad.mit.edu	37	10	127409777	127409777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:127409777C>T	ENST00000337623.3	+	2	218	c.113C>T	c.(112-114)tCa>tTa	p.S38L	C10orf137_ENST00000356792.4_Missense_Mutation_p.S38L	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AATTAGGGATCAGCTTTATTT	0.398000													35	97					0	0	1	0	0
CPNE1	8904	broad.mit.edu	37	20	34215285	34215285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34215285G>A	ENST00000317619.3	-	16	1547	c.1153C>T	c.(1153-1155)Ctc>Ttc	p.L385F	CPNE1_ENST00000397445.1_Missense_Mutation_p.L385F|CPNE1_ENST00000317677.5_Missense_Mutation_p.L390F|CPNE1_ENST00000397443.1_Missense_Mutation_p.L385F|CPNE1_ENST00000397442.1_Missense_Mutation_p.L385F|CPNE1_ENST00000397446.1_Missense_Mutation_p.L385F|CPNE1_ENST00000352393.4_Missense_Mutation_p.L385F			Q99829	CPNE1_HUMAN	copine I	385	VWFA.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GGGCCATAGAGGCGAACTTGG	0.577000													25	64					0	0	1	0	0
DOK5	55816	broad.mit.edu	37	20	53266970	53266970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:53266970G>A	ENST00000262593.5	+	8	1223	c.873G>A	c.(871-873)ctG>ctA	p.L291L	DOK5_ENST00000395939.1_Silent_p.L183L	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	291							insulin receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			CCAGCCCTCTGAAGCTTCATC	0.393000													22	44					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711904	20711904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20711904G>A	ENST00000315409.2	+	1	1007	c.954G>A	c.(952-954)atG>atA	p.M318I		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	318					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		TGTTTGGAATGAGAATTCGTC	0.393000													27	54					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763148	92763148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92763148C>T	ENST00000318238.4	-	5	3353	c.2137G>A	c.(2137-2139)Gac>Aac	p.D713N	SAMD9L_ENST00000411955.1_Missense_Mutation_p.D713N|SAMD9L_ENST00000437805.1_Missense_Mutation_p.D713N	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	713										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TCATAACTGTCCCTTTTAACA	0.343000													43	72					0	0	1	0	0
NLRP6	171389	broad.mit.edu	37	11	284265	284265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:284265G>A	ENST00000534750.1	+	6	2439	c.2234G>A	c.(2233-2235)cGa>cAa	p.R745Q	NLRP6_ENST00000312165.5_Missense_Mutation_p.R746Q	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	746						cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCGGTCTGCCGAGACCTTTCT	0.632000													11	31					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143958475	143958475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143958475C>T	ENST00000292427.4	-	3	591	c.559G>A	c.(559-561)Gac>Aac	p.D187N	CYP11B1_ENST00000377675.3_Missense_Mutation_p.D258N|CYP11B1_ENST00000517471.1_Missense_Mutation_p.D187N	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	187					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GGCTGGACGTCCAGGGTCAGG	0.637000									Familial Hyperaldosteronism type I				9	19					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241468740	241468740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241468740G>A	ENST00000391987.1	-	5	766	c.400C>T	c.(400-402)Ctc>Ttc	p.L134F	ANKMY1_ENST00000373318.2_Intron|ANKMY1_ENST00000405002.1_Intron|ANKMY1_ENST00000406958.1_Intron|ANKMY1_ENST00000361678.4_Intron|ANKMY1_ENST00000403283.1_Intron|ANKMY1_ENST00000462004.1_Intron|ANKMY1_ENST00000401804.1_Missense_Mutation_p.L223F|ANKMY1_ENST00000536462.1_Intron|ANKMY1_ENST00000373320.4_Intron|ANKMY1_ENST00000405523.3_Intron|ANKMY1_ENST00000272972.3_Missense_Mutation_p.L134F			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	134							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TCTTCTGAGAGGCTGATCCTG	0.542000													16	46					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129921147	129921147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129921147G>A	ENST00000368654.3	-	4	660	c.285C>T	c.(283-285)ttC>ttT	p.F95F	MKI67_ENST00000368653.3_Silent_p.F95F	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	95					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTACCTACCTGAAGGAACGAT	0.353000													8	44					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8221758	8221758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8221758G>A	ENST00000361926.3	+	10	1868	c.1758G>A	c.(1756-1758)aaG>aaA	p.K586K	ARHGEF15_ENST00000421050.1_Silent_p.K586K|AC135178.7_ENST00000458568.1_RNA	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	586	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						ATGCCCAGAAGGCCCTGGGTG	0.632000													45	48					0	0	1	0	0
STMN2	11075	broad.mit.edu	37	8	80567198	80567198	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:80567198C>T	ENST00000220876.7	+	4	763	c.381C>T	c.(379-381)ttC>ttT	p.F127F	STMN2_ENST00000518491.1_Silent_p.F116F|STMN2_ENST00000518111.1_Silent_p.F127F	NM_001199214.1|NM_007029.3	NP_001186143.1|NP_008960.2	Q93045	STMN2_HUMAN	stathmin-like 2	127					intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			ACAACAACTTCAGCAAGATGG	0.478000													20	43					0	0	1	0	0
FUT9	10690	broad.mit.edu	37	6	96651377	96651377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:96651377G>A	ENST00000302103.5	+	3	672	c.346G>A	c.(346-348)Gat>Aat	p.D116N		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	116					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CATCAGTTGGGATCTGACAAA	0.463000													16	30					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573667	140573667	+	Silent	SNP	C	C	T	rs17844573		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140573667C>T	ENST00000239446.4	+	1	1726	c.1542C>T	c.(1540-1542)ttC>ttT	p.F514F		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		514	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCACCTGTTCGCCCTCAGGT	0.701000													51	316					0	0	1	0	0
CHST11	50515	broad.mit.edu	37	12	105151002	105151002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:105151002C>T	ENST00000303694.5	+	3	919	c.480C>T	c.(478-480)aaC>aaT	p.N160N	CHST11_ENST00000549260.1_Silent_p.N155N	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	160					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						TCTCCGCCAACCTGAAGACCC	0.582000													17	54					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88474181	88474181	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:88474181A>G	ENST00000324166.5	+	2	1938	c.247A>G	c.(247-249)Aga>Gga	p.R83G	THNSL2_ENST00000449349.1_Missense_Mutation_p.R51G|THNSL2_ENST00000358591.2_Missense_Mutation_p.R83G|THNSL2_ENST00000377254.3_Missense_Mutation_p.R83G|THNSL2_ENST00000343544.4_Missense_Mutation_p.R83G|THNSL2_ENST00000402102.1_Missense_Mutation_p.R83G	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	83					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						AGCCTTCAGCAGATTCCGTCA	0.517000													33	85					0	0	1	0	0
TMEM74B	55321	broad.mit.edu	37	20	1162161	1162161	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1162161C>A	ENST00000381894.3	-	2	773	c.102G>T	c.(100-102)aaG>aaT	p.K34N	TMEM74B_ENST00000481747.1_5'UTR	NM_018354.1	NP_060824.1	Q9NUR3	CT046_HUMAN	transmembrane protein 74B	34						integral to membrane	protein binding										TGCTCAGTGTCTTCAGTTCCA	0.587000													4	52					0.00024832	0.00024867	1	1	0
MYO3A	53904	broad.mit.edu	37	10	26434399	26434399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26434399C>T	ENST00000265944.5	+	22	2607	c.2441C>T	c.(2440-2442)tCa>tTa	p.S814L	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	814	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AACCTGAAATCACAATACTTC	0.323000													11	49					0	0	1	0	0
SERINC5	256987	broad.mit.edu	37	5	79441966	79441966	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79441966G>A	ENST00000507668.2	-	11	1335	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F	SERINC5_ENST00000512972.2_Silent_p.F395F|SERINC5_ENST00000512721.1_Silent_p.F395F|SERINC5_ENST00000509193.1_Silent_p.F393F	NM_001174071.1|NM_178276.5	NP_001167542.1|NP_840060.1	Q86VE9	SERC5_HUMAN	serine incorporator 5	395					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|kidney(1)|lung(3)|ovary(1)	8		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GGAAGAACACGAAGTGGAAGT	0.488000													25	173					0	0	1	0	0
SLC17A9	63910	broad.mit.edu	37	20	61588800	61588800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61588800G>A	ENST00000370349.3	+	4	451	c.247G>A	c.(247-249)Ggt>Agt	p.G83S	SLC17A9_ENST00000370351.4_Missense_Mutation_p.G89S|SLC17A9_ENST00000488738.1_3'UTR			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	89					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						CAGGATTGGGGGTGAGAAGGT	0.642000													25	55					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810761	65810761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65810761G>A	ENST00000312006.4	-	3	794	c.513C>T	c.(511-513)gcC>gcT	p.A171A	GAL3ST3_ENST00000527878.1_Silent_p.A171A	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	171					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						CGCGCCGGAAGGCCGGGCAGT	0.662000													6	25					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104835967	104835967	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104835967C>T	ENST00000369878.3	+	7	2482	c.2358C>T	c.(2356-2358)ctC>ctT	p.L786L	CNNM2_ENST00000457502.2_Silent_p.L544L|CNNM2_ENST00000433628.2_Silent_p.L764L|CNNM2_ENST00000475511.1_3'UTR	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	786					ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ATTCTTCGCTCCTCCAAGTCT	0.537000													6	13					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57032929	57032929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57032929G>A	ENST00000262030.3	-	9	1500	c.1450C>T	c.(1450-1452)Ctg>Ttg	p.L484L	ATP5B_ENST00000552919.1_Silent_p.L473L	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	484					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GTCTCCTTCAGGGGTACCAGC	0.483000													69	108					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40689437	40689437	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40689437G>A	ENST00000298910.7	+	23	3145	c.3087G>A	c.(3085-3087)caG>caA	p.Q1029Q	LRRK2_ENST00000343742.2_Silent_p.Q1029Q	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1029					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTCCACAACAGCTATGTGAAG	0.338000													19	27					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54147547	54147547	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:54147547C>T	ENST00000265572.3	-	3	679	c.382G>A	c.(382-384)Gat>Aat	p.D128N	OPRK1_ENST00000520287.1_Missense_Mutation_p.D128N|OPRK1_ENST00000524278.1_Missense_Mutation_p.D39N|RP11-162D9.3_ENST00000524425.1_RNA	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	128					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CACAGCACATCCCCAAAAGGC	0.438000													42	77					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794844	126794844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126794844C>T	ENST00000373615.4	+	5	1818	c.1079C>T	c.(1078-1080)cCc>cTc	p.P360L		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	360						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						TCGCTCAGCCCCTCCAGCACG	0.657000													15	37					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169390881	169390881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169390881G>A	ENST00000545005.1	-	4	1295	c.788C>T	c.(787-789)tCt>tTt	p.S263F	CCDC181_ENST00000367806.3_Missense_Mutation_p.S263F|CCDC181_ENST00000367805.3_Missense_Mutation_p.S263F|CCDC181_ENST00000491570.1_5'UTR					coiled-coil domain containing 181																		GCCACTGACAGAGGAGTTGGA	0.458000													27	198					0	0	1	0	0
NOC2L	26155	broad.mit.edu	37	1	888594	888594	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:888594G>A	ENST00000327044.6	-	9	1012	c.963C>T	c.(961-963)tgC>tgT	p.C321C		NM_015658.3	NP_056473.2	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog (S. cerevisiae)	321						nucleolus	protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	16	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		TCTTGTGCCGGCAGACTCTGC	0.582000													4	43					0	0	1	0	0
CYP2F1	1572	broad.mit.edu	37	19	41628764	41628764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41628764C>T	ENST00000331105.2	+	7	932	c.860C>T	c.(859-861)aCc>aTc	p.T287I		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	287					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						CACATGGATACCCTGCTGATG	0.562000													15	45					0	0	1	0	0
GH2	2689	broad.mit.edu	37	17	61958450	61958450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61958450G>A	ENST00000332800.7	-	3	363	c.230C>T	c.(229-231)tCc>tTc	p.S77F	GH2_ENST00000456543.2_Missense_Mutation_p.S77F|GH2_ENST00000449787.2_Missense_Mutation_p.S62F|GH2_ENST00000423893.2_Missense_Mutation_p.S77F	NM_002059.4|NM_022557.3|NM_022558.3	NP_002050.1|NP_072051.1|NP_072052.1	P01242	SOM2_HUMAN	growth hormone 2	77						extracellular region	hormone activity			breast(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	24						GAAGCAGAGGGAGGTCTGGGG	0.532000													108	285					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20915652	20915652	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20915652G>A	ENST00000375071.3	+	1	212	c.30G>A	c.(28-30)ctG>ctA	p.L10L	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	10					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	CCTGCACCCTGAAGCCTGAGT	0.652000													13	72					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53679563	53679563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:53679563G>A	ENST00000262135.4	-	17	2750	c.2657C>T	c.(2656-2658)tCg>tTg	p.S886L	RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.S886L|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.S886L|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.S886L	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	886					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				ATGTGCCAACGAAATCAGAGG	0.328000													15	40					0	0	1	0	0
HAMP	57817	broad.mit.edu	37	19	35773543	35773543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35773543G>A	ENST00000598398.1	+	2	359	c.63G>A	c.(61-63)ctG>ctA	p.L21L	HAMP_ENST00000222304.3_Silent_p.L21L	NM_021175.2	NP_066998.1	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide	21					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TCGCCAGCCTGACCAGTGGCT	0.642000													64	125					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38451424	38451424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38451424G>A	ENST00000322350.5	+	19	2897	c.2551G>A	c.(2551-2553)Gga>Aga	p.G851R	EGFLAM_ENST00000506135.1_5'UTR|EGFLAM_ENST00000397210.3_5'UTR|EGFLAM_ENST00000397202.2_Missense_Mutation_p.G217R|EGFLAM_ENST00000514476.1_5'UTR|EGFLAM_ENST00000336740.6_Missense_Mutation_p.G617R|EGFLAM_ENST00000354891.3_Missense_Mutation_p.G859R	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	859	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					CAGGGTGTCAGGATCAAGATC	0.473000													46	170					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110413787	110413787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110413787C>T	ENST00000378402.5	+	14	1447	c.1343C>T	c.(1342-1344)tCa>tTa	p.S448L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	448					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACACAAAGATCAGATGATATT	0.333000										HNSCC(38;0.096)			8	37					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916090	42916090	+	Missense_Mutation	SNP	G	G	A	rs150584658		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42916090G>A	ENST00000316161.4	-	1	1543	c.1219C>T	c.(1219-1221)Cgc>Tgc	p.R407C	ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Missense_Mutation_p.R407C	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	407					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		TTGAGGAAGCGATCGTACTTG	0.557000													66	186					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81969801	81969801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81969801C>T	ENST00000359376.3	+	27	3084	c.2870C>T	c.(2869-2871)tCc>tTc	p.S957F		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	957	PI-PLC Y-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						GAAATCCGCTCCTTTGTGGAG	0.483000													6	56					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81372178	81372178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81372178G>A	ENST00000398636.3	+	4	421	c.283G>A	c.(283-285)Ggc>Agc	p.G95S	SFTPA1_ENST00000372313.5_Missense_Mutation_p.G36S|SFTPA1_ENST00000419470.2_Missense_Mutation_p.G110S|SFTPA1_ENST00000428376.2_Missense_Mutation_p.G95S|SFTPA1_ENST00000372308.3_Missense_Mutation_p.G95S	NM_001164644.1|NM_001164646.1|NM_005411.4	NP_001158116.1|NP_001158118.1|NP_005402.3	Q8IWL2	SFTA1_HUMAN	surfactant protein A1	95	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TGGCGAGAGGGGCCCTCCAGG	0.612000													103	72					0	0	1	0	0
OTOS	150677	broad.mit.edu	37	2	241078664	241078664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241078664C>T	ENST00000391989.2	-	5	423	c.193G>A	c.(193-195)Gac>Aac	p.D65N	OTOS_ENST00000319460.1_Missense_Mutation_p.D65N			Q8NHW6	OTOSP_HUMAN	otospiralin	65						extracellular region				endometrium(2)|large_intestine(1)|lung(3)	6		all_epithelial(40;2.79e-15)|Breast(86;3.04e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|Hepatocellular(293;0.148)|all_hematologic(139;0.158)|Melanoma(123;0.16)		Epithelial(32;2.56e-30)|all cancers(36;7.18e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.37e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.07e-06)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		CGGGCCATGTCCTCGATCTGG	0.637000													29	77					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23116264	23116264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:23116264C>T	ENST00000397677.1	+	8	1628	c.980C>T	c.(979-981)gCt>gTt	p.A327V	CHMP7_ENST00000520102.1_3'UTR|CHMP7_ENST00000313219.7_Missense_Mutation_p.A327V	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	327					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GCCTACCAGGCTGGGGTAGGA	0.463000													7	29					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78400326	78400326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:78400326C>T	ENST00000397909.2	+	8	1181	c.1008C>T	c.(1006-1008)tcC>tcT	p.S336S	NAV3_ENST00000266692.7_Silent_p.S336S|NAV3_ENST00000536525.2_Silent_p.S336S|NAV3_ENST00000228327.6_Silent_p.S336S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	336						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.S336S(1)		NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GCAGCAAGTCCATGAATGTCA	0.562000										HNSCC(70;0.22)			29	64					0	0	1	0	0
IGHA2	3494	broad.mit.edu	37	14	106053911	106053911	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106053911G>A	ENST00000390539.2	-	0	607																											GATGTTGGCGGTTAGTGGGGT	0.612000													20	45					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120572392	120572392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120572392G>A	ENST00000300648.6	-	52	7159	c.7147C>T	c.(7147-7149)Ccc>Tcc	p.P2383S		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2383					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGAAGAGGGGGTCCACCTTA	0.627000													27	49					0	0	1	0	0
SENP8	123228	broad.mit.edu	37	15	72432292	72432292	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72432292C>T	ENST00000544411.1	+	3	815	c.328C>T	c.(328-330)Caa>Taa	p.Q110*	SENP8_ENST00000542035.2_Nonsense_Mutation_p.Q110*|SENP8_ENST00000544171.1_Nonsense_Mutation_p.Q110*|SENP8_ENST00000340912.4_Nonsense_Mutation_p.Q110*	NM_001172109.1|NM_001172110.1	NP_001165580.1|NP_001165581.1	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	110	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			breast(1)|kidney(2)|lung(1)|ovary(1)|skin(1)	6						GGTCTACCTCCAAGATAAAAA	0.443000													23	99					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8168563	8168563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8168563C>T	ENST00000600128.1	-	39	5236	c.4822G>A	c.(4822-4824)Gaa>Aaa	p.E1608K	FBN3_ENST00000601739.1_Missense_Mutation_p.E1608K|FBN3_ENST00000270509.2_Missense_Mutation_p.E1608K			Q75N90	FBN3_HUMAN	fibrillin 3	1608	EGF-like 25; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTGGAGCATTCGTCAATATCT	0.562000													13	35					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100686297	100686297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100686297C>T	ENST00000306151.4	+	3	11664	c.11600C>T	c.(11599-11601)tCa>tTa	p.S3867L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3867						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ATACGTATTTCAATTACCAGT	0.478000													51	92					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38764987	38764987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38764987C>T	ENST00000449082.2	-	18	3285	c.3286G>A	c.(3286-3288)Gaa>Aaa	p.E1096K		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1096					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ctcaggatttcctcaggatct	0.592000													11	31					0	0	1	0	0
MEOX2	4223	broad.mit.edu	37	7	15666539	15666539	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:15666539G>A	ENST00000262041.5	-	2	931	c.522C>T	c.(520-522)tcC>tcT	p.S174S		NM_005924.4	NP_005915.2	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	174					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TTCCTTCCTGGGAGTCTGAAA	0.363000													27	72					0	0	1	0	0
PLEK	5341	broad.mit.edu	37	2	68607929	68607929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:68607929C>T	ENST00000234313.7	+	3	452	c.273C>T	c.(271-273)gcC>gcT	p.A91A		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	91	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGAGAGATGCCTGGGTTCGGG	0.468000													68	143					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32189084	32189084	+	Missense_Mutation	SNP	C	C	T	rs149758111		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32189084C>T	ENST00000375023.3	-	4	608	c.470G>A	c.(469-471)cGg>cAg	p.R157Q		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	157	EGF-like 4.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						ACAGAAGTCCCGAAGCTGGCA	0.577000													20	34					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55145563	55145563	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55145563G>A	ENST00000414150.2	+	13	2504		c.e13-1		MROH7_ENST00000339553.5_Splice_Site|MROH7_ENST00000545244.1_Splice_Site|MROH7_ENST00000454855.2_Splice_Site|MROH7_ENST00000421030.2_Splice_Site|MROH7_ENST00000409996.1_Splice_Site|MROH7_ENST00000395690.2_Splice_Site					maestro heat-like repeat family member 7																		CTGTGCCCCAGATCCCAGAAA	0.657000													60	158					0	0	1	0	0
PPARA	5465	broad.mit.edu	37	22	46615854	46615854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46615854C>T	ENST00000396000.2	+	6	919	c.654C>T	c.(652-654)ttC>ttT	p.F218F	PPARA_ENST00000402126.1_Silent_p.F218F|PPARA_ENST00000262735.5_Silent_p.F218F|PPARA_ENST00000407236.1_Silent_p.F218F|PPARA_ENST00000434345.2_Intron			Q07869	PPARA_HUMAN	peroxisome proliferator-activated receptor alpha	218					fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	15		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	TGAAGAACTTCAACATGAACA	0.453000													4	40					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24460566	24460566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24460566C>T	ENST00000230036.1	-	12	1059	c.949G>A	c.(949-951)Gac>Aac	p.D317N		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	317						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						ATATTCCTGTCAACACTTTCA	0.373000													18	184					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211639	38211639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38211639C>T	ENST00000379705.3	-	11	3192	c.2335G>A	c.(2335-2337)Gaa>Aaa	p.E779K	TRPC4_ENST00000358477.2_Missense_Mutation_p.E779K|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000379673.2_Missense_Mutation_p.E714K|TRPC4_ENST00000338947.5_Missense_Mutation_p.E606K|TRPC4_ENST00000355779.2_Intron|TRPC4_ENST00000379679.1_Missense_Mutation_p.E606K|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379681.3_Missense_Mutation_p.E784K			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	779	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TCACTCTTTTCATCTGAGTCT	0.423000													31	100					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37546855	37546855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:37546855G>A	ENST00000299824.1	+	11	1439	c.1250G>A	c.(1249-1251)cGa>cAa	p.R417Q	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.R375Q	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	417					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding	p.R417Q(1)		biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				AAGATCCCACGAGGTGAACTG	0.572000													46	184					0	0	1	0	0
NOMO2	283820	broad.mit.edu	37	16	18544465	18544465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:18544465G>A	ENST00000330537.6	-	12	1427	c.1257C>T	c.(1255-1257)ttC>ttT	p.F419F	NOMO2_ENST00000543392.1_Silent_p.F252F|NOMO2_ENST00000381474.3_Silent_p.F419F	NM_173614.2	NP_775885.1	Q5JPE7	NOMO2_HUMAN	NODAL modulator 2	419						endoplasmic reticulum membrane|integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(3)|lung(5)|ovary(3)|prostate(1)|skin(1)	20						CGGTGTCCGGGAAGCGAATGA	0.453000													35	154					0	0	1	0	0
LCN9	392399	broad.mit.edu	37	9	138557709	138557709	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138557709C>T	ENST00000277526.3	+	6	478	c.478C>T	c.(478-480)Ccc>Tcc	p.P160S	LCN9_ENST00000430290.2_3'UTR	NM_001001676.1	NP_001001676.1	Q8WX39	LCN9_HUMAN	lipocalin 9	160						extracellular region	pheromone binding|transporter activity			kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	6		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		CCTTCCAGATCCCTGCTACTC	0.692000													6	19					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52781677	52781677	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52781677G>A	ENST00000245457.5	+	1	565	c.411G>A	c.(409-411)tcG>tcA	p.S137S	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	137						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	GCTACCTCTCGATCGGGCACC	0.652000													14	140					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6125817	6125817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6125817G>A	ENST00000261405.5	-	30	5430	c.5176C>T	c.(5176-5178)Cgt>Tgt	p.R1726C		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1726	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding	p.R1726S(1)		NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TGAGTGAGACGAGGCCCTAAA	0.527000													22	68					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112358111	112358111	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112358111C>T	ENST00000206423.3	-	2	1595	c.642G>A	c.(640-642)ctG>ctA	p.L214L	CCDC80_ENST00000439685.2_Silent_p.L214L	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	214										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						GGCTAGGGTCCAGGGGCTGCT	0.582000													19	136					0	0	1	0	0
PIFO	128344	broad.mit.edu	37	1	111889590	111889590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111889590C>T	ENST00000369738.4	+	2	443	c.78C>T	c.(76-78)ttC>ttT	p.F26F	PIFO_ENST00000369737.4_Silent_p.F26F|PIFO_ENST00000484512.1_3'UTR	NM_181643.4	NP_857594.2			primary cilia formation																		TTCCTCACTTCCATCCCCCGA	0.493000													25	70					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75248565	75248565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75248565C>T	ENST00000325680.7	+	4	1943	c.1819C>T	c.(1819-1821)Cca>Tca	p.P607S	YLPM1_ENST00000552421.1_Missense_Mutation_p.P607S|YLPM1_ENST00000238571.3_Intron	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGTTCTTCCCCCACCATCTCT	0.597000													71	129					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515443	140515443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140515443C>T	ENST00000231134.5	+	1	644	c.427C>T	c.(427-429)Cca>Tca	p.P143S		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		143	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTAAAAATCCCAGAGAGCAC	0.443000													20	87					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140358575	140358575	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140358575G>A	ENST00000532602.1	+	2	3469	c.2436G>A	c.(2434-2436)ctG>ctA	p.L812L	PCDHA6_ENST00000527624.1_Silent_p.L548L|PCDHA12_ENST00000398631.2_Silent_p.L803L|PCDHA13_ENST00000409494.1_Silent_p.L812L|PCDHAC1_ENST00000253807.2_Silent_p.L825L|PCDHA6_ENST00000529310.1_Silent_p.L812L|PCDHA1_ENST00000394633.3_Silent_p.L548L|PCDHA5_ENST00000529619.1_Silent_p.L798L|PCDHA10_ENST00000307360.5_Silent_p.L810L|PCDHA8_ENST00000531613.1_Silent_p.L812L|PCDHA13_ENST00000289272.2_Silent_p.L812L|PCDHA4_ENST00000512229.2_Silent_p.L809L|PCDHA11_ENST00000398640.2_Silent_p.L811L|PCDHA1_ENST00000504120.2_Silent_p.L812L|PCDHAC2_ENST00000289269.5_Silent_p.L869L|PCDHA3_ENST00000522353.2_Silent_p.L812L|PCDHA10_ENST00000506939.2_Silent_p.L547L|PCDHA2_ENST00000526136.1_Silent_p.L810L|PCDHA7_ENST00000525929.1_Silent_p.L799L|PCDHA4_ENST00000530339.1_Silent_p.L809L|PCDHA5_ENST00000529859.1_Silent_p.L798L	NM_031857.1	NP_114063.1												p.L812L(6)|p.L810L(2)|p.L809L(1)|p.L547L(1)|p.L825L(1)|p.L799L(1)|p.L811L(1)|p.L803L(1)|p.L798L(1)|p.L869L(1)		breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCCTCCCTGAGAGCAGGCA	0.468000													15	73					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19654261	19654261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19654261C>T	ENST00000328041.6	+	9	927	c.730C>T	c.(730-732)Ctt>Ttt	p.L244F		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	244						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GTCTTTAGTCCTTGTGCTGAT	0.353000													23	59					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11231096	11231096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11231096C>T	ENST00000558518.1	+	14	2225	c.2038C>T	c.(2038-2040)Ctg>Ttg	p.L680L	LDLR_ENST00000455727.2_Silent_p.L512L|LDLR_ENST00000558013.1_Silent_p.L680L|LDLR_ENST00000545707.1_Intron|LDLR_ENST00000535915.1_Silent_p.L639L|LDLR_ENST00000557933.1_Silent_p.L680L	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	680	EGF-like 3.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CTGCCAGTATCTGTGCCTCCC	0.622000													15	72					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566468	136566468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136566468G>A	ENST00000264162.2	-	8	3459	c.3449C>T	c.(3448-3450)tCc>tTc	p.S1150F		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1150	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCAGCCCAGGGAGAACTGCAG	0.562000													39	60					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33840369	33840369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33840369C>T	ENST00000389232.4	+	9	849	c.779C>T	c.(778-780)gCc>gTc	p.A260V	RYR3_ENST00000415757.3_Missense_Mutation_p.A260V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	260	MIR 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGGACTCGAGCCAGGTCTCTT	0.512000													4	24					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167142880	167142880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167142880C>T	ENST00000375387.4	-	11	1911	c.1571G>A	c.(1570-1572)cGa>cAa	p.R524Q	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.R523Q|SCN9A_ENST00000409435.1_Missense_Mutation_p.R523Q|SCN9A_ENST00000303354.6_Missense_Mutation_p.R524Q			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	523						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R523L(1)		NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTCATGTGCTCGCCTATGCCC	0.438000													71	262					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131107735	131107735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131107735C>T	ENST00000300456.3	+	3	580	c.463C>T	c.(463-465)Ctc>Ttc	p.L155F	SLC27A4_ENST00000372870.1_Intron	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	155					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						GGAGGCAGCCCTCATCAACAC	0.647000													4	18					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27802752	27802752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27802752G>A	ENST00000408964.2	+	1	3364	c.3313G>A	c.(3313-3315)Gat>Aat	p.D1105N		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1105										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					AATACCCCCCGATGTGCCTCC	0.453000													24	103					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3142167	3142167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3142167G>A	ENST00000252463.2	-	2	469	c.382C>T	c.(382-384)Cga>Tga	p.R128*	ZSCAN10_ENST00000575108.1_5'UTR|ZSCAN10_ENST00000538082.2_Intron|ZSCAN10_ENST00000572548.1_Intron	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	128	Pro-rich.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						GGCTGGGGTCGGGGAGGCTCA	0.652000													15	39					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27134413	27134413	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27134413C>T	ENST00000343060.4	-	2	715	c.652_splice	c.e2-1	p.G218_splice	HOXA1_ENST00000355633.5_3'UTR	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	218						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CTCCAACTTTCCCTGGGGCAA	0.493000													26	42					0	0	1	0	0
FASLG	356	broad.mit.edu	37	1	172628472	172628472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:172628472G>A	ENST00000367721.2	+	1	315	c.131G>A	c.(130-132)aGg>aAg	p.R44K	FASLG_ENST00000340030.3_Missense_Mutation_p.R44K	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	44	Pro-rich.				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						GGTCAAAGGAGGccaccacca	0.657000													10	20					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6267018	6267018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6267018C>T	ENST00000264870.3	-	4	609	c.344G>A	c.(343-345)gGa>gAa	p.G115E		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	115					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GATGTAGGTTCCCTTGTTCTC	0.463000													59	124					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169632887	169632887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169632887G>A	ENST00000335742.7	+	10	1988	c.631G>A	c.(631-633)Ggc>Agc	p.G211S	PALLD_ENST00000512127.1_Missense_Mutation_p.G211S|PALLD_ENST00000261509.6_Missense_Mutation_p.G593S|PALLD_ENST00000505667.1_Missense_Mutation_p.G593S			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	593					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCCTGAGTTAGGCCTGAGCAG	0.512000									Pancreatic Cancer, Familial Clustering of				26	42					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73679476	73679476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73679476C>T	ENST00000339764.1	+	6	1444	c.693C>T	c.(691-693)ttC>ttT	p.F231F	RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000543947.1_Silent_p.F56F|DNAJB13_ENST00000537753.1_Silent_p.F56F	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	231					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					ACAACCTCTTCTTCGTGAACC	0.592000													16	32					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25005324	25005324	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25005324C>A	ENST00000382114.4	-	8	1572	c.1387G>T	c.(1387-1389)Ggg>Tgg	p.G463W		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	463						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				GTCATGGCCCCCCGGGATGGA	0.502000													53	186					1.38658e-30	1.39611e-30	1	1	0
COL5A3	50509	broad.mit.edu	37	19	10088273	10088273	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10088273G>A	ENST00000264828.3	-	42	3208	c.3123C>T	c.(3121-3123)tcC>tcT	p.S1041S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1041	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CACTTACCCGGGACCCCTTCT	0.642000													6	26					0	0	1	0	0
R3HCC1L	27291	broad.mit.edu	37	10	99968552	99968552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99968552C>T	ENST00000298999.3	+	5	984	c.681C>T	c.(679-681)gtC>gtT	p.V227V	R3HCC1L_ENST00000370584.3_Silent_p.V227V|R3HCC1L_ENST00000314594.5_5'UTR|R3HCC1L_ENST00000370586.2_Intron	NM_014472.4	NP_055287.4			R3H domain and coiled-coil containing 1-like																		TTAGTTCTGTCATGAAACCTG	0.353000													33	59					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43749275	43749275	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43749275G>A	ENST00000263801.3	-	12	1768	c.1516C>T	c.(1516-1518)Cta>Tta	p.L506L	TP53BP1_ENST00000382039.3_Silent_p.L511L|TP53BP1_ENST00000450115.2_Silent_p.L511L|TP53BP1_ENST00000382044.4_Silent_p.L511L	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	506					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTCAAAGATAGCCCAAGATCC	0.403000								Other conserved DNA damage response genes					25	70					0	0	1	0	0
INPP5A	3632	broad.mit.edu	37	10	134579348	134579348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134579348C>T	ENST00000368594.3	+	12	1252	c.975C>T	c.(973-975)ccC>ccT	p.P325P	INPP5A_ENST00000368593.3_Silent_p.P325P	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	325					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CGTTCCCTCCCAGGTATGGAA	0.498000													19	55					0	0	1	0	0
DGCR6	8214	broad.mit.edu	37	22	18897764	18897764	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18897764G>A	ENST00000331444.6	+	3	503	c.351G>A	c.(349-351)gcG>gcA	p.A117A	DGCR6_ENST00000413981.1_5'UTR|DGCR6_ENST00000436645.1_3'UTR	NM_005675.4	NP_005666.2	Q14129	DGCR6_HUMAN	DiGeorge syndrome critical region gene 6	117			A -> V (in dbSNP:rs16983281).		cell adhesion|organ morphogenesis	nucleus|proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|upper_aerodigestive_tract(1)	3						TGCTTCAGGCGGCTCAGCAGC	0.672000													4	15					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29121194	29121194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29121194G>A	ENST00000261590.8	+	13	2127	c.1918G>A	c.(1918-1920)Ggc>Agc	p.G640S		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	640					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TTGCGGAAAGGGCGCCAAAGG	0.428000													27	71					0	0	1	0	0
RBM48	84060	broad.mit.edu	37	7	92164170	92164170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92164170C>T	ENST00000481551.1	+	4	944	c.903C>T	c.(901-903)aaC>aaT	p.N301N	RBM48_ENST00000265732.5_Silent_p.N301N			Q5RL73	CG064_HUMAN	RNA binding motif protein 48	301							nucleotide binding										TTCAAACAAACCCAACTGGTA	0.413000													18	40					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686601	54686601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54686601C>T	ENST00000540264.2	-	2	1188	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	NFE2_ENST00000312156.4_Missense_Mutation_p.E227K|RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000553070.1_Missense_Mutation_p.E227K|NFE2_ENST00000435572.2_Missense_Mutation_p.E227K			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	227					blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						GCCCGACGTTCATCCCGACTC	0.577000													14	24					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6476061	6476061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:6476061G>A	ENST00000297056.6	-	3	520	c.351C>T	c.(349-351)gcC>gcT	p.A117A	DAGLB_ENST00000425398.2_Silent_p.A117A|DAGLB_ENST00000421761.2_Intron|DAGLB_ENST00000479922.2_5'UTR|DAGLB_ENST00000428902.2_Intron|DAGLB_ENST00000436575.1_Silent_p.A76A	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta	117					lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CTGCCACCCAGGCAGCCCCCA	0.542000													66	120					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50290710	50290710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50290710G>A	ENST00000338821.5	-	11	1283	c.1019C>T	c.(1018-1020)tCc>tTc	p.S340F	ATP9A_ENST00000311637.5_Missense_Mutation_p.S204F|ATP9A_ENST00000402822.1_Missense_Mutation_p.S219F	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	340					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GATGATGTTGGAAAACAAGAG	0.512000													15	60					0	0	1	0	0
ACAP3	116983	broad.mit.edu	37	1	1230858	1230858	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1230858G>A	ENST00000354700.5	-	19	1984	c.1782C>T	c.(1780-1782)ttC>ttT	p.F594F	ACAP3_ENST00000353662.3_Silent_p.F552F	NM_030649.2	NP_085152.2	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	594					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			endometrium(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	14						CCCCTGCGTCGAAGTAGGAGA	0.667000													4	54					0	0	1	0	0
CDC42EP3	10602	broad.mit.edu	37	2	37873403	37873403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37873403G>A	ENST00000295324.3	-	2	1328	c.328C>T	c.(328-330)Ccg>Tcg	p.P110S	AC006369.2_ENST00000419425.1_RNA	NM_001270436.1|NM_001270437.1|NM_001270438.1|NM_006449.3	NP_001257365.1|NP_001257366.1|NP_001257367.1|NP_006440.2	Q9UKI2	BORG2_HUMAN	CDC42 effector protein (Rho GTPase binding) 3	110					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding			endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	11		all_hematologic(82;0.172)				CCAATGGTCGGGAGGGAGATG	0.547000													18	151					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38357943	38357943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38357943C>T	ENST00000273173.4	+	9	1752	c.1661C>T	c.(1660-1662)tCc>tTc	p.S554F	SLC22A14_ENST00000448498.1_Missense_Mutation_p.S554F	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	554						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GTGGCCTTTTCCCTCTCCTCC	0.612000													17	37					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26446395	26446395	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26446395C>T	ENST00000265944.5	+	26	3116	c.2950C>T	c.(2950-2952)Cga>Tga	p.R984*	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	984	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.R984*(3)		NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGCAAGAATTCGAAGACTAGG	0.363000													39	101					0	0	1	0	0
CHST2	9435	broad.mit.edu	37	3	142840921	142840921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142840921G>A	ENST00000309575.3	+	2	2647	c.1263G>A	c.(1261-1263)ctG>ctA	p.L421L		NM_004267.4	NP_004258.2	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	421					inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(2)	22						GCCACTACCTGGTGGTGCGGT	0.587000													7	59					0	0	1	0	0
ELOVL7	79993	broad.mit.edu	37	5	60067763	60067763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:60067763G>A	ENST00000505959.1	-	6	709	c.183C>T	c.(181-183)ttC>ttT	p.F61F	ELOVL7_ENST00000508821.1_Silent_p.F74F|ELOVL7_ENST00000425382.1_Silent_p.F74F|ELOVL7_ENST00000438340.1_Silent_p.F74F			A1L3X0	ELOV7_HUMAN	ELOVL fatty acid elongase 7	74					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	9		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				AGAGTACTATGAAAAAATTGT	0.358000													14	30					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233323688	233323688	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233323688G>A	ENST00000295463.3	+	11	1496	c.1419G>A	c.(1417-1419)gaG>gaA	p.E473E		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	473					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GTGTGCAGGAGCAGAGCTTCG	0.711000													6	14					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140434525	140434525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:140434525G>A	ENST00000288602.6	-	18	2233	c.2173C>T	c.(2173-2175)Cac>Tac	p.H725Y		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	725					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GCACTGCGGTGAATTTTTGGC	0.393000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				57	143					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10916776	10916776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10916776C>T	ENST00000254488.2	+	6	953	c.887C>T	c.(886-888)cCc>cTc	p.P296L		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	296					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CTCTCCGACCCCCAGGTAAGA	0.592000													9	73					0	0	1	0	0
GRB2	2885	broad.mit.edu	37	17	73322082	73322082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73322082G>A	ENST00000392562.1	-	4	978	c.196C>T	c.(196-198)Ccc>Tcc	p.P66S	GRB2_ENST00000392563.1_Intron|GRB2_ENST00000392564.1_Missense_Mutation_p.P66S|GRB2_ENST00000578961.1_Missense_Mutation_p.P66S|GRB2_ENST00000316804.5_Missense_Mutation_p.P66S|GRB2_ENST00000462266.1_5'UTR|GRB2_ENST00000316615.5_Intron			P62993	GRB2_HUMAN	growth factor receptor-bound protein 2	66	SH2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	17	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	TTGGCTCTGGGGATTTTGCCA	0.507000													34	77					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594352	140594352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140594352C>T	ENST00000341948.4	+	1	844	c.657C>T	c.(655-657)ggC>ggT	p.G219G		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		219	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGATGGTGGCTCTCCGCCCA	0.532000													36	142					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663602	169663602	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169663602G>A	ENST00000483289.2	-	0	3692				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						AGAGGGGAAAGACCACTCTTC	0.423000													5	16					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207758215	207758215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207758215C>T	ENST00000367049.4	+	33	5524	c.5524C>T	c.(5524-5526)Cgt>Tgt	p.R1842C	CR1_ENST00000367052.1_Missense_Mutation_p.R1392C|CR1_ENST00000367051.1_Missense_Mutation_p.R1392C|CR1_ENST00000400960.2_Missense_Mutation_p.R1392C|RP11-78B10.2_ENST00000596003.1_RNA|RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367053.1_Missense_Mutation_p.R1392C	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1392	Sushi 28.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ACTTTCTGTTCGTGCTGGTCA	0.488000													41	86					0	0	1	0	0
OR10W1	81341	broad.mit.edu	37	11	58035215	58035215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58035215G>A	ENST00000395079.2	-	1	517	c.116C>T	c.(115-117)tCc>tTc	p.S39F		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				TGTGTGAATGGACACCACAAT	0.488000													22	60					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130789705	130789705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:130789705C>T	ENST00000276708.4	-	2	1010	c.129G>A	c.(127-129)aaG>aaA	p.K43K		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	43						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						AACGAGAATCCTTCTTCTTTC	0.393000													40	85					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475396	120475396	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:120475396C>T	ENST00000355622.6	+	3	1091	c.990C>T	c.(988-990)ttC>ttT	p.F330F	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.F290F	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	330					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity	p.F330F(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CTTATAATTTCGGATGGCAAC	0.323000													20	77					0	0	1	0	0
OR1F1	4992	broad.mit.edu	37	16	3255061	3255061	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3255061C>T	ENST00000304646.2	+	1	815	c.815C>T	c.(814-816)aCt>aTt	p.T272I	AJ003147.9_ENST00000576468.1_RNA	NM_012360.1	NP_036492.1	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F, member 1	272					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(7)	11						GAGAAAGACACTATGGCTACT	0.468000													40	144					0	0	1	0	0
ODAM	54959	broad.mit.edu	37	4	71068536	71068536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71068536G>A	ENST00000396094.2	+	9	760	c.712G>A	c.(712-714)Gga>Aga	p.G238R		NM_017855.3	NP_060325.3	A1E959	ODAM_HUMAN	odontogenic, ameloblast asssociated	238					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(3)|skin(2)	20						TGACAGTGCAGGAGTTTTCAT	0.413000													24	78					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31498855	31498855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31498855C>T	ENST00000330498.3	+	7	679	c.660C>T	c.(658-660)ttC>ttT	p.F220F	AC026471.6_ENST00000565137.1_RNA	NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	220					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						CGGCAGCCTTCCACGAGGTGG	0.667000													28	87					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159409	18159409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18159409C>T	ENST00000396275.2	+	3	1021	c.660C>T	c.(658-660)ctC>ctT	p.L220L		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	220						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						CCATCCTCCTCACAGTGCTGG	0.552000													28	77					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207642028	207642028	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207642028G>A	ENST00000367057.3	+	3	791	c.602G>A	c.(601-603)gGa>gAa	p.G201E	CR2_ENST00000367059.3_Missense_Mutation_p.G201E|CR2_ENST00000458541.2_Missense_Mutation_p.G201E|CR2_ENST00000367058.3_Missense_Mutation_p.G201E|CR2_ENST00000485707.1_3'UTR	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	201	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TTGTCTTCGGGAAAATGGAGT	0.418000													55	160					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13185135	13185135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13185135C>T	ENST00000379345.2	+	5	575	c.334C>T	c.(334-336)Cct>Tct	p.P112S	PHACTR1_ENST00000457702.2_Intron|PHACTR1_ENST00000379350.1_Intron|PHACTR1_ENST00000332995.7_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	51						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TGCTGCTTTCCCTGGAGACCA	0.577000													29	99					0	0	1	0	0
WNT6	7475	broad.mit.edu	37	2	219738374	219738374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219738374C>T	ENST00000233948.3	+	4	1122	c.905C>T	c.(904-906)tCc>tTc	p.S302F		NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	302					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCACCGGCTCCCCCGGCACG	0.761000													9	18					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13829732	13829732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13829732G>A	ENST00000265104.4	-	38	6435	c.6331C>T	c.(6331-6333)Cgt>Tgt	p.R2111C		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2111	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATAATCTGACGGTCAGGCACC	0.463000									Kartagener syndrome				25	83					0	0	1	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1629548	1629548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1629548C>T	ENST00000399685.1	-	1	145	c.68G>A	c.(67-69)gGc>gAc	p.G23D		NM_001012708.2	NP_001012726.1	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	23						keratin filament				endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	8		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		GGAGCCACAGCCCCCACAGCT	0.662000													67	142					0	0	1	0	0
DDAH1	23576	broad.mit.edu	37	1	85817238	85817238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85817238G>A	ENST00000284031.8	-	3	522	c.428C>T	c.(427-429)tCc>tTc	p.S143F	DDAH1_ENST00000483110.1_5'UTR|RP11-131L23.1_ENST00000427819.1_RNA|DDAH1_ENST00000542148.1_Missense_Mutation_p.S43F|RP11-131L23.1_ENST00000426125.1_RNA|DDAH1_ENST00000539042.1_Missense_Mutation_p.S143F|DDAH1_ENST00000426972.3_Missense_Mutation_p.S50F|DDAH1_ENST00000535924.2_Missense_Mutation_p.S40F	NM_012137.3	NP_036269.1	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	143					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|skin(1)	5				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	TGTCCTTTTGGAAAGGCCCAC	0.363000													12	105					0	0	1	0	0
NUBP2	10101	broad.mit.edu	37	16	1838710	1838710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1838710C>T	ENST00000262302.9	+	7	931	c.811C>T	c.(811-813)Ccc>Tcc	p.P271S	NUBP2_ENST00000565987.1_Missense_Mutation_p.P211S|NUBP2_ENST00000543305.1_Missense_Mutation_p.P130S|NUBP2_ENST00000568706.1_Missense_Mutation_p.P130S	NM_012225.2	NP_036357.1	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2	271						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						CGCGTGCCTCCCCTGACTAAG	0.662000													5	23					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61844389	61844389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61844389C>T	ENST00000280772.1	-	32	4236	c.4045G>A	c.(4045-4047)Gag>Aag	p.E1349K	ANK3_ENST00000503366.1_Missense_Mutation_p.E1350K|ANK3_ENST00000373827.2_Missense_Mutation_p.E1343K|ANK3_ENST00000355288.2_Missense_Mutation_p.E483K	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1349					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCGACTTCCTCAAAATTCTCT	0.363000													46	128					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189065014	189065014	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189065014G>A	ENST00000332517.3	+	4	898	c.758_splice	c.e4+1	p.R253_splice	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	253					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GCCCTGGAAAGGTAGGCTTTC	0.493000													48	199					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327814	85327814	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85327814C>T	ENST00000299927.3	+	1	1930	c.1908C>T	c.(1906-1908)gcC>gcT	p.A636A	ZNF592_ENST00000560079.2_Silent_p.A636A			Q92610	ZN592_HUMAN	zinc finger protein 592	636					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCCGGCACGCCCGTGACCACA	0.597000													20	84					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3655168	3655168	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3655168C>T	ENST00000263087.4	-	15	1767	c.1668_splice	c.e15-1	p.D557_splice		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	557					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		AAAGAACCATCCTGTAAAGCA	0.597000													25	29					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78547309	78547309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78547309G>A	ENST00000545128.1	+	2	745	c.207G>A	c.(205-207)aaG>aaA	p.K69K	PCSK5_ENST00000376752.4_Silent_p.K69K|PCSK5_ENST00000376767.3_Silent_p.K69K	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	69					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GGGCCCTGAAGGACTACTACC	0.408000													22	46					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96698454	96698454	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96698454G>A	ENST00000260682.6	+	1	27	c.15G>A	c.(13-15)gtG>gtA	p.V5V	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	5					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	ATTCTCTTGTGGTCCTTGTGC	0.493000													94	239					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233137405	233137405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233137405G>A	ENST00000258229.8	-	29	5209	c.4975C>T	c.(4975-4977)Ctc>Ttc	p.L1659F	PCNXL2_ENST00000344698.2_Missense_Mutation_p.L311F	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1659						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGGACATGGAGGCCATACAGG	0.433000													5	11					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1395328	1395328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1395328G>A	ENST00000324385.5	+	22	2282	c.2124G>A	c.(2122-2124)agG>agA	p.R708R	BAIAP3_ENST00000568887.1_Silent_p.R645R|BAIAP3_ENST00000562208.1_Silent_p.R650R|BAIAP3_ENST00000421665.2_Silent_p.R637R|BAIAP3_ENST00000397488.2_Silent_p.R690R|BAIAP3_ENST00000397489.1_Silent_p.R690R|BAIAP3_ENST00000426824.3_Silent_p.R673R	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	708	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				AAGTGCTGAGGGACCAGGCCA	0.672000													21	32					0	0	1	0	0
EVL	51466	broad.mit.edu	37	14	100551165	100551165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100551165C>T	ENST00000544450.2	+	2	448	c.165C>T	c.(163-165)gtC>gtT	p.V55V	EVL_ENST00000402714.2_Silent_p.V49V|EVL_ENST00000392920.3_Silent_p.V51V|EVL_ENST00000555048.1_3'UTR			Q9UI08	EVL_HUMAN	Enah/Vasp-like	49	WH1.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				CCTTCAGAGTCGTTGGAGTCA	0.527000													10	87					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2884530	2884530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:2884530C>T	ENST00000254695.8	+	10	807	c.717C>T	c.(715-717)gtC>gtT	p.V239V	RAP1GAP2_ENST00000542807.1_Silent_p.V239V|RAP1GAP2_ENST00000540393.2_Silent_p.V220V|RAP1GAP2_ENST00000366401.4_Silent_p.V224V	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	239					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						TCAATCCTGTCCTGTACCCCA	0.527000													8	10					0	0	1	0	0
EPT1	85465	broad.mit.edu	37	2	26607905	26607905	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26607905C>T	ENST00000260585.7	+	8	929	c.810C>T	c.(808-810)ttC>ttT	p.F270F		NM_033505.2	NP_277040.1	Q9C0D9	EPT1_HUMAN	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	270					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding										GCTTGCTGTTCATTTTGTCTA	0.358000													14	48					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156631840	156631840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156631840C>T	ENST00000296518.7	+	6	732	c.523C>T	c.(523-525)Cat>Tat	p.H175Y	GUCY1A3_ENST00000511108.1_Missense_Mutation_p.H175Y|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.H175Y|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.H175Y|GUCY1A3_ENST00000393832.3_5'UTR|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.H175Y|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.H175Y			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	175				VIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLK QSSHCQEAGKRGR -> LSKNLLVKRFLKYVTRKMKTSLGW LEAPLKIFKQLQYPSETEQPLPRSRKKGQ (in Ref. 1).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ACAGAGCAGCCATTGCCAAGA	0.433000													29	57					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50213657	50213657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50213657C>T	ENST00000392518.4	+	15	2019	c.1647C>T	c.(1645-1647)tcC>tcT	p.S549S	CPT1C_ENST00000323446.5_Silent_p.S549S|CPT1C_ENST00000598293.1_Silent_p.S549S|CPT1C_ENST00000354199.5_Silent_p.S549S|CPT1C_ENST00000405931.2_Silent_p.S538S	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	549					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTCCATTCTCCCTATTTGGCA	0.557000													17	87					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234458964	234458964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:234458964G>A	ENST00000366618.3	+	8	1593	c.1448G>A	c.(1447-1449)aGa>aAa	p.R483K	SLC35F3_ENST00000366617.3_Missense_Mutation_p.R414K	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	414					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			AAGAACAGAAGAGCCCGCCCT	0.577000											OREG0014330	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	46					0	0	1	0	0
ADRA1B	147	broad.mit.edu	37	5	159344514	159344514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:159344514C>T	ENST00000306675.3	+	1	725	c.602C>T	c.(601-603)cCc>cTc	p.P201L		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	201					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	ACCGAAGAACCCTTCTATGCC	0.567000													46	109					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597445	136597445	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136597445C>T	ENST00000531224.1	-	5	1470	c.1218G>A	c.(1216-1218)gaG>gaA	p.E406E	BCLAF1_ENST00000392348.2_Silent_p.E404E|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000527759.1_Silent_p.E404E|BCLAF1_ENST00000527536.1_Silent_p.E406E|BCLAF1_ENST00000353331.4_Silent_p.E404E	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	406					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GTCTATAATCCTCTGTCTCCT	0.428000													32	522					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95610021	95610021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95610021G>A	ENST00000395505.2	-	3	1032	c.940C>T	c.(940-942)Cat>Tat	p.H314Y	ZNF484_ENST00000332591.6_Missense_Mutation_p.H314Y|ZNF484_ENST00000375495.3_Missense_Mutation_p.H350Y|ANKRD19P_ENST00000473204.1_RNA|ZNF484_ENST00000395506.3_Missense_Mutation_p.H352Y	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						TCTCCAGAATGAATTCTCTGG	0.368000													15	42					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368424	86368424	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:86368424C>T	ENST00000400286.2	-	2	2818	c.2220G>A	c.(2218-2220)acG>acA	p.T740T		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	740						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TTGATTGGTTCGTGGTTTTGT	0.368000													85	302					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196709789	196709789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196709789C>T	ENST00000312428.6	-	47	8982	c.8882G>A	c.(8881-8883)cGa>cAa	p.R2961Q		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2961	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATTCCAAGTTCGAATTGTCAC	0.363000													8	43					0	0	1	0	0
VOPP1	81552	broad.mit.edu	37	7	55560108	55560108	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55560108G>A	ENST00000285279.5	-	4	395	c.195C>T	c.(193-195)ttC>ttT	p.F65F	VOPP1_ENST00000433959.1_Silent_p.F56F|VOPP1_ENST00000454227.1_Silent_p.F2F|VOPP1_ENST00000453256.1_5'UTR|VOPP1_ENST00000428097.1_5'UTR|VOPP1_ENST00000428648.1_5'UTR|VOPP1_ENST00000545390.1_Silent_p.F62F|VOPP1_ENST00000418904.1_Silent_p.F48F|VOPP1_ENST00000427700.1_Silent_p.F63F	NM_030796.3	NP_110423.3	Q96AW1	VOPP1_HUMAN	vesicular, overexpressed in cancer, prosurvival protein 1	65					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity			endometrium(1)|lung(4)	5						TCATCAGAAGGAACCTGAGGA	0.632000													5	19					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502112	90502112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90502112G>A	ENST00000325643.5	+	4	2776	c.2710G>A	c.(2710-2712)Gga>Aga	p.G904R		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GAATGGTCCAGGAGACAACAG	0.597000													10	60					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18725192	18725192	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18725192G>A	ENST00000440756.2	-	4	1728	c.1626C>T	c.(1624-1626)ttC>ttT	p.F542F	PSD3_ENST00000327040.8_Silent_p.F542F|PSD3_ENST00000523619.1_Silent_p.F477F			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	542	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACCTTCCCCAGAAAGCAATCT	0.458000													6	67					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103568562	103568562	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103568562T>C	ENST00000380069.3	+	2	578	c.502T>C	c.(502-504)Ttt>Ctt	p.F168L		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	168										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CTCGCGCACCTTTGAGCAGGA	0.662000													5	7					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67124879	67124879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67124879G>A	ENST00000284425.2	-	8	1174	c.1000C>T	c.(1000-1002)Ctc>Ttc	p.L334F		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	334					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AGGGTAAGGAGAAACACAACC	0.408000													25	117					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	167020477	167020477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:167020477C>T	ENST00000061240.2	+	20	3352	c.2705C>T	c.(2704-2706)tCa>tTa	p.S902L	TLL1_ENST00000507499.1_Missense_Mutation_p.S925L	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	902	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GATCTGTACTCACATGCTCAG	0.443000													70	145					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58342391	58342391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58342391C>T	ENST00000371015.1	+	5	1159	c.692C>T	c.(691-693)cCc>cTc	p.P231L	PHACTR3_ENST00000541461.1_Missense_Mutation_p.P190L|PHACTR3_ENST00000395636.2_Missense_Mutation_p.P190L|PHACTR3_ENST00000395639.4_Intron|PHACTR3_ENST00000361300.4_Intron|PHACTR3_ENST00000355648.4_Missense_Mutation_p.P190L|PHACTR3_ENST00000359926.3_Missense_Mutation_p.P228L	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	231	Pro-rich.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CTCCCCAGCCCCCCACTGCTG	0.592000													18	38					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173915704	173915704	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173915704G>A	ENST00000367696.2	-	17	3222	c.2871C>T	c.(2869-2871)ccC>ccT	p.P957P	RC3H1_ENST00000258349.4_Silent_p.P957P|RC3H1_ENST00000367694.2_Silent_p.P957P			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	957					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						CAGATGGAAGGGGTTTTCCAT	0.413000													20	94					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59283076	59283076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59283076G>A	ENST00000329328.3	+	1	691	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						TCACACTGGGGAAGGCAGGAG	0.502000													26	262					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39316095	39316095	+	Missense_Mutation	SNP	C	C	T	rs148389506		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39316095C>T	ENST00000263408.4	-	6	747	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	218	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ATTTGTTCTTCGTAATGTTCG	0.303000													15	43					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101190431	101190431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:101190431G>A	ENST00000294728.2	+	4	1014	c.913G>A	c.(913-915)Gaa>Aaa	p.E305K	VCAM1_ENST00000370119.4_Missense_Mutation_p.E243K|VCAM1_ENST00000370115.1_Missense_Mutation_p.E305K|VCAM1_ENST00000347652.2_Missense_Mutation_p.E305K	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	305	Ig-like C2-type 3.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AAAAGAGGTGGAATTAATTGT	0.373000													10	62					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8890460	8890460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:8890460G>A	ENST00000256707.3	-	24	3377	c.3196C>T	c.(3196-3198)Cgt>Tgt	p.R1066C	KIDINS220_ENST00000418530.1_Missense_Mutation_p.R1024C|KIDINS220_ENST00000473731.1_Missense_Mutation_p.R1066C|KIDINS220_ENST00000427284.1_Missense_Mutation_p.R1066C	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1066					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTGGCAGCACGAACATCTGAA	0.512000													9	25					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064729	78064729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:78064729C>T	ENST00000299642.4	+	3	697	c.612C>T	c.(610-612)atC>atT	p.I204I	CLEC3A_ENST00000575655.1_Silent_p.I195I|CLEC3A_ENST00000565808.1_3'UTR|RP11-281J9.2_ENST00000563114.1_RNA	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	195					skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						AGTTCACCATCCCTCAATAGG	0.423000													5	42					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834355	101834355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101834355C>T	ENST00000506729.1	-	1	365	c.194G>A	c.(193-195)cGa>cAa	p.R65Q	SLCO6A1_ENST00000379810.1_Missense_Mutation_p.R65Q|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.R65Q|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.R65Q|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.R65Q			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	65						integral to membrane|plasma membrane	transporter activity	p.R65Q(2)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TTTCCTTTTTCGGAAACCGCC	0.542000													80	215					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64152334	64152334	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:64152334C>T	ENST00000395391.1	+	3	1390	c.15C>T	c.(13-15)ccC>ccT	p.P5P	ZNF107_ENST00000344930.3_Silent_p.P5P|ZNF107_ENST00000423627.1_Silent_p.P5P			Q9UII5	ZN107_HUMAN	zinc finger protein 107	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TAGCCAAACCCCCAGGTAGGT	0.398000													23	144					0	0	1	0	0
DCD	117159	broad.mit.edu	37	12	55039011	55039011	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55039011C>T	ENST00000456047.2	-	4	424	c.235G>A	c.(235-237)Gga>Aga	p.G79R	DCD_ENST00000293371.6_Missense_Mutation_p.G79R			P81605	DCD_HUMAN	dermcidin	79					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			large_intestine(2)|lung(2)|ovary(1)|skin(1)	6		Myeloproliferative disorder(1001;0.0255)				TTTCCGAGTCCCCCCACAGCT	0.478000													33	87					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73636011	73636011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73636011G>A	ENST00000261917.3	-	2	1917	c.924C>T	c.(922-924)atC>atT	p.I308I		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	308					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GGACCAAGTCGATGAGGAAGA	0.488000													10	58					0	0	1	0	0
P2RX5	5026	broad.mit.edu	37	17	3595104	3595104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3595104C>T	ENST00000552050.1	-	1	192	c.14G>A	c.(13-15)cGg>cAg	p.R5Q	P2RX5_ENST00000435558.1_Intron|P2RX5_ENST00000552276.1_Intron|P2RX5_ENST00000225328.5_Intron|P2RX5_ENST00000345901.3_Intron|RP11-48B14.2_ENST00000550383.1_Intron|P2RX5_ENST00000547178.1_Intron|P2RX5_ENST00000551178.1_Intron			Q93086	P2RX5_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 5	0					nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						GGAAGGGGGCCGGTACGTGGG	0.602000													14	83					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114290925	114290925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:114290925C>T	ENST00000297405.5	-	3	654	c.410G>A	c.(409-411)gGa>gAa	p.G137E	CSMD3_ENST00000352409.3_Missense_Mutation_p.G137E|CSMD3_ENST00000343508.3_Missense_Mutation_p.G97E|CSMD3_ENST00000455883.2_Missense_Mutation_p.G137E	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	137	CUB 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAGATGGAATCCTGTTAACCT	0.308000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	67					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091388	9091388	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9091388C>T	ENST00000397910.4	-	1	630	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	143	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.E143K(2)|p.E143Q(2)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTAGATGCTTCTTTGGTAAAA	0.488000													31	55					0	0	1	0	0
NANOS3	342977	broad.mit.edu	37	19	13988354	13988354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13988354G>A	ENST00000397555.2	+	2	235	c.235G>A	c.(235-237)Gag>Aag	p.E79K	NANOS3_ENST00000339133.5_Missense_Mutation_p.E98K|NANOS3_ENST00000591727.1_Intron|NANOS3_ENST00000591161.1_Intron	NM_001098622.2	NP_001092092.1	P60323	NANO3_HUMAN	nanos homolog 3 (Drosophila)	79					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding	p.E98K(1)		breast(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	7			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GCTGAAGGACGAGGCTGGCAG	0.662000													10	36					0	0	1	0	0
SHISA3	152573	broad.mit.edu	37	4	42403225	42403225	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42403225C>T	ENST00000319234.4	+	2	692	c.474C>T	c.(472-474)ccC>ccT	p.P158P		NM_001080505.1	NP_001073974.1	A0PJX4	SHSA3_HUMAN	shisa family member 3	158					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	12						CCAGGGCACCCTCCCGGCAGT	0.667000													64	162					0	0	1	0	0
ZNF619	285267	broad.mit.edu	37	3	40529675	40529675	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:40529675C>T	ENST00000447116.2	+	6	2101	c.1794C>T	c.(1792-1794)ctC>ctT	p.L598L	ZNF619_ENST00000521353.1_Silent_p.L598L|ZNF619_ENST00000432264.2_Silent_p.L558L|ZNF619_ENST00000429348.2_Silent_p.L558L|ZNF619_ENST00000456778.1_Silent_p.L514L|ZNF619_ENST00000314686.5_Silent_p.L542L|ZNF619_ENST00000522736.1_Silent_p.L549L|ZNF619_ENST00000520737.1_3'UTR	NM_001145082.2	NP_001138554.1	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619	598					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TTCAGGATCTCGCTTTTCCTG	0.498000													98	78					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29012409	29012409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29012409G>A	ENST00000282397.4	-	4	713	c.462C>T	c.(460-462)ctC>ctT	p.L154L	FLT1_ENST00000539099.1_Silent_p.L154L|FLT1_ENST00000541932.1_Silent_p.L154L	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	154	Ig-like C2-type 2.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AGGGAATGACGAGCTCCCTTC	0.388000													41	20					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628876	71628876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71628876C>T	ENST00000377276.2	-	1	163	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	45	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CTGAGCCGTTCGAACTGATCC	0.602000													13	55					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325311	150325311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150325311G>A	ENST00000493969.1	-	3	328	c.151C>T	c.(151-153)Cgt>Tgt	p.R51C	GIMAP6_ENST00000328902.5_Silent_p.A125A	NM_001244071.1	NP_001231000.1	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	0							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCAGGAGCACGGCGTGGGGCC	0.622000													32	68					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7651534	7651534	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7651534C>T	ENST00000359156.4	-	4	910	c.708G>A	c.(706-708)tgG>tgA	p.W236*	CD163_ENST00000432237.2_Nonsense_Mutation_p.W236*|CD163_ENST00000396620.3_Nonsense_Mutation_p.W236*|CD163_ENST00000541972.1_Nonsense_Mutation_p.W224*	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	236	SRCR 2.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GTTTGCAGTTCCAGAGAGCTG	0.433000													55	172					0	0	1	0	0
GPR171	29909	broad.mit.edu	37	3	150916563	150916563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:150916563C>T	ENST00000309180.5	-	3	841	c.611G>A	c.(610-612)cGa>cAa	p.R204Q	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_013308.3	NP_037440.3	O14626	GP171_HUMAN	G protein-coupled receptor 171	204						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(4)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	15			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTAGAGCTGTCGAATTACAAG	0.328000													19	45					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3645678	3645678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3645678G>A	ENST00000294008.3	-	9	2581	c.1941C>T	c.(1939-1941)ccC>ccT	p.P647P		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	647	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						GAAGGCCGCCGGGCACCACGT	0.622000								Direct reversal of damage					14	38					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43547729	43547729	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43547729G>A	ENST00000395891.1	+	23	4470	c.3866_splice	c.e23+1	p.G1289_splice	HECW1_ENST00000453890.1_Splice_Site_p.G1255_splice	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1289	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TGGAGAGGAGGGGTGAGGCAC	0.532000													6	46					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241659339	241659339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241659339G>A	ENST00000498729.2	-	46	5119	c.4873C>T	c.(4873-4875)Ccg>Tcg	p.P1625S	KIF1A_ENST00000320389.7_Missense_Mutation_p.P1524S	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1524	PH.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CAGGGCTGCGGGGTCCTGGGA	0.682000													7	24					0	0	1	0	0
HEXA	3073	broad.mit.edu	37	15	72638914	72638914	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72638914G>A	ENST00000268097.5	-	11	1787	c.1284C>T	c.(1282-1284)ggC>ggT	p.G428G	HEXA_ENST00000429918.2_Silent_p.G255G|RP11-106M3.2_ENST00000379915.4_RNA|RP11-106M3.3_ENST00000570175.1_RNA|HEXA_ENST00000566304.1_Silent_p.G439G|HEXA_ENST00000457859.2_Intron|HEXA_ENST00000567159.1_Silent_p.G428G	NM_000520.4	NP_000511.2	P06865	HEXA_HUMAN	hexosaminidase A (alpha polypeptide)	428					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(3)|kidney(3)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	24						TCCAGTCAGGGCCATAGGATA	0.537000													113	204					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15990683	15990683	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15990683G>A	ENST00000221700.5	-	10	1235	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F	CYP4F2_ENST00000592328.1_Silent_p.F380F	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	380					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACATGGTCAGGAAGGGCAAAT	0.577000													59	129					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	53989385	53989385	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:53989385G>A	ENST00000514921.1	+	3	447	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	MLIP_ENST00000502396.1_Missense_Mutation_p.E123K|MLIP_ENST00000358276.5_Missense_Mutation_p.E106K|MLIP_ENST00000370877.2_Missense_Mutation_p.E60K|MLIP_ENST00000509997.1_Missense_Mutation_p.E60K|MLIP_ENST00000370876.2_Missense_Mutation_p.E50K|MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000274897.5_Missense_Mutation_p.E112K			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	112						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						AAGGGAATTCGAAGCAAACAA	0.453000													34	95					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171055856	171055856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171055856G>A	ENST00000334231.6	+	2	168	c.168G>A	c.(166-168)aaG>aaA	p.K56K	MYO3B_ENST00000408978.4_Silent_p.K47K|MYO3B_ENST00000409044.3_Silent_p.K47K|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	47	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						TAACTAACAAGAGAGATGGGA	0.418000													9	48					0	0	1	0	0
TRAK2	66008	broad.mit.edu	37	2	202245709	202245709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202245709G>A	ENST00000332624.3	-	16	2730	c.2302C>T	c.(2302-2304)Cct>Tct	p.P768S		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	768				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						AGGGATTTAGGGAGAGGCTGG	0.512000													16	169					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002110	98002110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98002110C>T	ENST00000355273.2	+	1	379	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						GGCATATGATCGCTATGTAGC	0.378000													9	125					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60899610	60899610	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60899610C>T	ENST00000252999.3	-	42	5596	c.5529_splice	c.e42-1	p.E1844_splice		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1844	Laminin EGF-like 16; second part.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGCACATTCCTGAGGGTGT	0.627000													9	11					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114276620	114276620	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114276620C>T	ENST00000357077.4	+	38	6899	c.6846C>T	c.(6844-6846)acC>acT	p.T2282T	ANK2_ENST00000264366.6_Silent_p.T2249T|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2249					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCCCACGACCAAAGACATTA	0.483000													12	39					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48650406	48650406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48650406G>A	ENST00000352832.5	+	7	1444	c.1072G>A	c.(1072-1074)Gac>Aac	p.D358N	CACNA1G_ENST00000512389.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000507336.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000507609.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000354983.4_Missense_Mutation_p.D358N|CACNA1G_ENST00000503485.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000507896.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000358244.5_Missense_Mutation_p.D358N|CACNA1G_ENST00000510115.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000510366.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000502264.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000429973.2_Missense_Mutation_p.D358N|CACNA1G_ENST00000416767.4_Missense_Mutation_p.D358N|CACNA1G_ENST00000360761.4_Missense_Mutation_p.D358N|CACNA1G_ENST00000515765.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000515411.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000442258.2_Missense_Mutation_p.D358N|CACNA1G_ENST00000515165.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000505165.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000359106.5_Missense_Mutation_p.D358N|CACNA1G_ENST00000514717.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000514181.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000514079.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000513964.1_Missense_Mutation_p.D358N|CACNA1G_ENST00000507510.2_Missense_Mutation_p.D358N|CACNA1G_ENST00000513689.2_Missense_Mutation_p.D358N	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	358					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGGCTGGGTCGACATCATGTA	0.552000													4	8					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102611376	102611376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:102611376G>A	ENST00000251808.3	+	8	1433	c.1095G>A	c.(1093-1095)gcG>gcA	p.A365A	GRHL2_ENST00000395927.1_Silent_p.A349A	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	365						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATGAAGAGGCGAAGGTGAGTG	0.378000													15	26					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3200901	3200901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3200901G>A	ENST00000520002.1	-	24	4104	c.3549C>T	c.(3547-3549)atC>atT	p.I1183I	CSMD1_ENST00000542608.1_Silent_p.I1182I|CSMD1_ENST00000539096.1_Silent_p.I1182I|CSMD1_ENST00000537824.1_Silent_p.I1182I|CSMD1_ENST00000602723.1_Silent_p.I1183I|CSMD1_ENST00000400186.3_Silent_p.I1183I|CSMD1_ENST00000602557.1_Silent_p.I1183I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1183	CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCTGTTTAGGATCAGCCCCA	0.448000													19	63					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40900930	40900930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40900930C>T	ENST00000324001.7	-	7	3599	c.3329G>A	c.(3328-3330)gGg>gAg	p.G1110E	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1110	Glu-rich (acidic).				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTCTGCCCTCCCTTCCTCCTG	0.667000													22	62					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24689299	24689299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:24689299G>A	ENST00000396475.2	+	5	638	c.339G>A	c.(337-339)atG>atA	p.M113I	MPP6_ENST00000222644.4_Missense_Mutation_p.M113I|MPP6_ENST00000409761.1_Start_Codon_SNP_p.M1I	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	113					protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						GCCCAGAAATGAATAATTCTT	0.383000													24	84					0	0	1	0	0
ZNF467	168544	broad.mit.edu	37	7	149468110	149468110	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149468110G>A	ENST00000302017.3	-	2	425	c.12C>T	c.(10-12)acC>acT	p.T4T	ZNF467_ENST00000484747.1_Silent_p.T4T	NM_207336.1	NP_997219.1	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|urinary_tract(1)	13	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGGCCTCCAAGGTCTCTCTCA	0.542000													31	91					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21051370	21051370	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21051370G>A	ENST00000381545.3	+	14	1902	c.1682_splice	c.e14-1	p.K561_splice	SLCO1B3_ENST00000261196.2_Splice_Site_p.K561_splice|LST3_ENST00000540229.1_Splice_Site_p.K561_splice|SLCO1B3_ENST00000553473.1_Splice_Site_p.K561_splice|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	561					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					CATATTTCAGGATTGTTCAAC	0.299000													16	71					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71795107	71795107	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71795107C>T	ENST00000258104.3	+	25	2815	c.2538C>T	c.(2536-2538)gcC>gcT	p.A846A	DYSF_ENST00000394120.2_Silent_p.A847A|DYSF_ENST00000409744.1_Silent_p.A833A|DYSF_ENST00000410020.3_Silent_p.A864A|DYSF_ENST00000413539.2_Silent_p.A877A|DYSF_ENST00000429174.2_Silent_p.A846A|DYSF_ENST00000409366.1_Silent_p.A847A|DYSF_ENST00000409582.3_Silent_p.A863A|DYSF_ENST00000409762.1_Silent_p.A863A|DYSF_ENST00000409651.1_Silent_p.A878A|DYSF_ENST00000410041.1_Silent_p.A864A	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	846						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TGCCTGGCGCCCGGATGCCAG	0.572000													35	65					0	0	1	0	0
HLA-V	352962	broad.mit.edu	37	6	29761626	29761626	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29761626C>T	ENST00000457107.1	+	0	852																											tccccttgtcctgttgtaagt	0.502000													8	19					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24924372	24924372	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24924372C>T	ENST00000329468.2	+	1	3832	c.3358C>T	c.(3358-3360)Caa>Taa	p.Q1120*		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TCCTGCTTTTCAACAGTGCAT	0.468000													75	115					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42331169	42331169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42331169C>T	ENST00000217026.4	+	8	1118	c.991C>T	c.(991-993)Cct>Tct	p.P331S	MYBL2_ENST00000396863.4_Missense_Mutation_p.P307S	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	331						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ATTTGACCTCCCTGAGGAACC	0.522000													20	215					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47405400	47405400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47405400C>T	ENST00000285039.7	-	24	3490	c.3191G>A	c.(3190-3192)cGa>cAa	p.R1064Q	MYO5B_ENST00000324581.6_Missense_Mutation_p.R205Q	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1064					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GTACCGGGATCGCTCCTCCTC	0.468000													23	60					0	0	1	0	0
ABCG1	9619	broad.mit.edu	37	21	43708058	43708058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43708058C>T	ENST00000398437.1	+	10	1619	c.1471C>T	c.(1471-1473)Cgg>Tgg	p.R491W	ABCG1_ENST00000398449.3_Missense_Mutation_p.R345W|ABCG1_ENST00000343687.3_Missense_Mutation_p.R356W|ABCG1_ENST00000361802.2_Missense_Mutation_p.R345W|ABCG1_ENST00000340588.4_Missense_Mutation_p.R453W|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000398457.2_Missense_Mutation_p.R347W|ABCG1_ENST00000347800.2_Missense_Mutation_p.R342W			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	345	ABC transmembrane type-2.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	GAGAGCGGTTCGGGAGGGCAT	0.602000													46	218					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43610524	43610524	+	Silent	SNP	C	C	T	rs138052948		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43610524C>T	ENST00000372806.3	+	4	395	c.300C>T	c.(298-300)atC>atT	p.I100I	STK4_ENST00000396731.4_Silent_p.I100I|STK4_ENST00000372801.1_Silent_p.I100I|STK4_ENST00000499879.2_Silent_p.I100I	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	100	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding	p.I100I(1)		NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				ACTTATGGATCGTTATGGAGT	0.363000													32	54					0	0	1	0	0
GARS	2617	broad.mit.edu	37	7	30671904	30671904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30671904G>A	ENST00000389266.3	+	16	2186	c.1945G>A	c.(1945-1947)Gat>Aat	p.D649N		NM_002047.2	NP_002038.2	P41250	SYG_HUMAN	glycyl-tRNA synthetase	649					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	24					Glycine(DB00145)	CAAAGTAGACGATTCCTCTGG	0.448000													26	72					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56646657	56646657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56646657G>A	ENST00000267116.7	-	12	1329	c.1208C>T	c.(1207-1209)tCa>tTa	p.S403L		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	403							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						ATTGCTGAGTGAAGACACAAT	0.512000													7	14					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96745809	96745809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96745809C>T	ENST00000260682.6	+	8	1181	c.1169C>T	c.(1168-1170)tCc>tTc	p.S390F		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	390					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	ATATTAATTTCCCTGACTTCT	0.378000													47	134					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995902	140995902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140995902C>T	ENST00000285879.4	+	4	2998	c.2712C>T	c.(2710-2712)ttC>ttT	p.F904F	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	904							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AGCCCTTGTTCACTTATACAC	0.478000										HNSCC(15;0.026)			84	77					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71411594	71411594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71411594G>A	ENST00000302628.4	+	4	363	c.286G>A	c.(286-288)Gag>Aag	p.E96K	CALB2_ENST00000349553.5_Missense_Mutation_p.E96K	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	96	EF-hand 2.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				GCCAACCGAAGAGAACTTCCT	0.552000													21	71					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101546431	101546431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101546431G>A	ENST00000353234.4	-	4	963	c.916C>T	c.(916-918)Cag>Tag	p.Q306*	ANKS6_ENST00000540940.1_Nonsense_Mutation_p.Q111*|ANKS6_ENST00000375019.2_Nonsense_Mutation_p.Q5*|ANKS6_ENST00000375018.1_Nonsense_Mutation_p.Q306*			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	306										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				TTGACCAGCTGGAAGTTTCCT	0.557000													13	29					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7769021	7769021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7769021G>A	ENST00000358415.4	+	10	1259	c.1093G>A	c.(1093-1095)Gct>Act	p.A365T	ITIH2_ENST00000379587.4_Missense_Mutation_p.A354T	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	365	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TTTAATTTCAGCTACAAAAAC	0.423000													21	65					0	0	1	0	0
SLAMF7	57823	broad.mit.edu	37	1	160719701	160719701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160719701G>A	ENST00000368043.3	+	3	504	c.467G>A	c.(466-468)gGg>gAg	p.G156E	SLAMF7_ENST00000441662.2_Intron|SLAMF7_ENST00000444090.2_Intron|SLAMF7_ENST00000368042.3_Missense_Mutation_p.G49E|SLAMF7_ENST00000359331.4_Missense_Mutation_p.G156E|SLAMF7_ENST00000458602.2_Missense_Mutation_p.G49E|SLAMF7_ENST00000458104.2_Missense_Mutation_p.G49E	NM_021181.3	NP_067004.3	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	156	Ig-like C2-type.				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATGGAACATGGGGAAGAGGAT	0.522000													41	108					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29142344	29142344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29142344G>A	ENST00000377167.2	+	1	1034	c.932G>A	c.(931-933)gGg>gAg	p.G311E		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TGGGAGTGGGGGAAGTGACAG	0.423000													24	45					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47286726	47286726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:47286726C>T	ENST00000311191.6	+	15	1877	c.1648C>T	c.(1648-1650)Cga>Tga	p.R550*	LRCH1_ENST00000389797.3_Nonsense_Mutation_p.R550*|LRCH1_ENST00000389798.3_Nonsense_Mutation_p.R550*	NM_001164213.1	NP_001157685.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	550										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CCTGAAGCCTCGATCAGGTAA	0.423000													63	130					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48451735	48451735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48451735G>A	ENST00000358536.4	-	31	5844	c.5575C>T	c.(5575-5577)Cgg>Tgg	p.R1859W	PLXNB1_ENST00000456774.1_Missense_Mutation_p.R1676W|PLXNB1_ENST00000296440.6_Missense_Mutation_p.R1859W|PLXNB1_ENST00000358459.4_Missense_Mutation_p.R1676W|PLXNB1_ENST00000448774.2_Missense_Mutation_p.R470W	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1859					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGGTTTTCCCGGAGCACATGC	0.627000													9	38					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9119182	9119182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:9119182C>T	ENST00000382496.5	-	15	2518	c.1853G>A	c.(1852-1854)cGg>cAg	p.R618Q		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	618	TSP type-1 2.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GGAGCGCTGCCGCACCTGGAA	0.652000													8	25					0	0	1	0	0
SCARB1	949	broad.mit.edu	37	12	125270724	125270724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125270724G>A	ENST00000415380.2	-	11	1705	c.1580C>T	c.(1579-1581)tCt>tTt	p.S527F	SCARB1_ENST00000339570.5_Intron|SCARB1_ENST00000541205.1_Missense_Mutation_p.S486F|SCARB1_ENST00000261693.6_Intron|SCARB1_ENST00000540495.1_Missense_Mutation_p.S490F|SCARB1_ENST00000376788.1_Intron|SCARB1_ENST00000535005.1_Intron|SCARB1_ENST00000544327.1_Missense_Mutation_p.S473F|SCARB1_ENST00000546215.1_Intron			Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1	527					adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	GCATGCAAAAGACGCAAGCGT	0.642000													8	9					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19753537	19753537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:19753537C>T	ENST00000400113.3	-	2	274	c.170G>A	c.(169-171)gGa>gAa	p.G57E		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	57					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CTTGCCAGCTCCAGTCTCACT	0.562000													29	108					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46962038	46962038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46962038C>T	ENST00000374323.3	-	7	1944	c.1357G>A	c.(1357-1359)Gag>Aag	p.E453K	RP11-38L15.3_ENST00000506914.1_RNA|SYT15_ENST00000503753.1_Intron|SYT15_ENST00000374321.4_Missense_Mutation_p.E400K|SYT15_ENST00000374325.3_Intron			Q9BQS2	SYT15_HUMAN	synaptotagmin XV	400						integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						CTGAGCATCTCGTCCCAGTGC	0.677000													20	79					0	0	1	0	0
MIR7162	102466227	broad.mit.edu	37	15	62539576	62539576	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:62539576C>T	ENST00000570077.1	-	0	206																											GCATACTGCTCTCTCTCCATT	0.567000													14	19					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925084	54925084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54925084G>A	ENST00000293373.6	+	23	2626	c.2547G>A	c.(2545-2547)atG>atA	p.M849I	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.M799I	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	849					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CCTATGGCATGAAGTTCCTGA	0.507000													18	221					0	0	1	0	0
SRCRB4D	136853	broad.mit.edu	37	7	76027102	76027102	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76027102G>A	ENST00000275560.3	-	6	948	c.601C>T	c.(601-603)Cga>Tga	p.R201*	ZP3_ENST00000336517.4_5'UTR	NM_080744.1	NP_542782.1	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain containing, group B (4 domains)	201	SRCR 2.					extracellular region|membrane	scavenger receptor activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(9)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21						ATCTCCACTCGGCCCTGACAC	0.711000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604980	179604980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179604980G>A	ENST00000589042.1	-	48	13204	c.12980C>T	c.(12979-12981)tCc>tTc	p.S4327F	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S3964F|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S4156F|TTN_ENST00000359218.5_Missense_Mutation_p.S4089F|TTN_ENST00000591111.1_Missense_Mutation_p.S4010F|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4010	Ig-like 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAATCTTAAGGACTTGCCTTC	0.433000													36	88					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52514231	52514231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52514231C>T	ENST00000345716.4	+	13	1582	c.1448C>T	c.(1447-1449)cCc>cTc	p.P483L	NISCH_ENST00000488380.1_Missense_Mutation_p.P483L|NISCH_ENST00000479054.1_Missense_Mutation_p.P483L|NISCH_ENST00000420808.2_Missense_Mutation_p.P483L	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	483	Interaction with PAK1 (By similarity).|Necessary for homooligomerization and targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TCAGCTGCCCCCTGCATCAGA	0.617000													25	82					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87679347	87679347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87679347G>A	ENST00000320005.5	-	6	705	c.658C>T	c.(658-660)Ctg>Ttg	p.L220L		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	220					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AAGAGCCACAGGAGATAGAGT	0.448000													9	31					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98807467	98807467	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98807467G>A	ENST00000266058.4	-	16	1859	c.1614C>T	c.(1612-1614)atC>atT	p.I538I	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.I538I	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	538	LRRNT 3.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TGGACTGGGGGATGCGCTCAG	0.627000													29	71					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239025621	239025621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239025621G>A	ENST00000343063.3	+	5	1196	c.933G>A	c.(931-933)gcG>gcA	p.A311A	ESPNL_ENST00000409169.1_Intron	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	311										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CAGACCTGGCGGAGTACCATG	0.677000													10	17					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3638194	3638194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3638194G>A	ENST00000263087.4	-	21	2670	c.2572C>T	c.(2572-2574)Cta>Tta	p.L858L	ITGAE_ENST00000571185.1_5'UTR	NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	858					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GAGTTAGTTAGGTTAATGTTC	0.463000													23	167					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47222299	47222299	+	Silent	SNP	C	C	T	rs151317740	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:47222299C>T	ENST00000319190.5	+	8	1394	c.1026C>T	c.(1024-1026)atC>atT	p.I342I	TTC7A_ENST00000263737.6_5'UTR|TTC7A_ENST00000461601.1_3'UTR|TTC7A_ENST00000409245.1_Silent_p.I308I|TTC7A_ENST00000394850.2_Silent_p.I342I	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	342							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			AGGACAACATCGAGGAAGCCC	0.597000													15	35					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169494601	169494601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169494601G>A	ENST00000256935.8	+	45	4635	c.4555G>A	c.(4555-4557)Gat>Aat	p.D1519N	DOCK2_ENST00000520908.1_Missense_Mutation_p.D1011N|DOCK2_ENST00000540750.1_Missense_Mutation_p.D580N|DOCK2_ENST00000523351.1_3'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1519	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTACCAGAGTGATGAGACCCT	0.493000													29	106					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110842035	110842035	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110842035C>A	ENST00000296632.3	-	3	282	c.148G>T	c.(148-150)Gga>Tga	p.G50*	STARD4_ENST00000509887.1_Nonsense_Mutation_p.G50*|STARD4_ENST00000502322.1_Nonsense_Mutation_p.G50*|STARD4_ENST00000511569.1_5'UTR|STARD4_ENST00000512160.1_Nonsense_Mutation_p.G50*	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	50	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		TACAGATATCCATTAAATTCT	0.303000													8	24					1.58986e-06	1.59358e-06	1	1	0
ALOX5	240	broad.mit.edu	37	10	45877960	45877960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45877960G>A	ENST00000374391.2	+	2	233	c.180G>A	c.(178-180)gaG>gaA	p.E60E	ALOX5_ENST00000542434.1_Silent_p.E60E	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	60	PLAT.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CTGTGGACGAGGAACTGGGCG	0.542000													18	48					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97251363	97251363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97251363C>T	ENST00000389672.5	+	11	2400	c.2362C>T	c.(2362-2364)Cgc>Tgc	p.R788C	EPHA6_ENST00000514100.1_Missense_Mutation_p.R180C|EPHA6_ENST00000442602.2_Missense_Mutation_p.R154C|EPHA6_ENST00000502694.1_Missense_Mutation_p.R180C	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	693	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AAACATCATTCGCCTAGAAGG	0.378000													14	51					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135980	156135980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156135980G>A	ENST00000329476.3	+	2	1378	c.889G>A	c.(889-891)Gtc>Atc	p.V297I	NPY2R_ENST00000506608.1_Missense_Mutation_p.V297I	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	297					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				TGACAGCCAGGTCCTGGACCT	0.522000													13	55					0	0	1	0	0
KRT6B	3854	broad.mit.edu	37	12	52844213	52844213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52844213G>A	ENST00000252252.3	-	2	779	c.732C>T	c.(730-732)gaC>gaT	p.D244D		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	244	Coil 1B.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		CCTCCACCAGGTCCTGCATGT	0.542000													15	173					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35450246	35450246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35450246G>A	ENST00000404801.1	-	4	899	c.513C>T	c.(511-513)ttC>ttT	p.F171F	ZNF792_ENST00000605484.1_Silent_p.F104F	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGTTTGCACTGAACTCAGAGC	0.507000													122	219					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155254414	155254414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155254414G>A	ENST00000357232.3	-	9	1448	c.1449C>T	c.(1447-1449)acC>acT	p.T483T	DCHS2_ENST00000339452.1_Silent_p.T982T|DCHS2_ENST00000507542.1_5'UTR	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	483	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCTCATCCGAGGTCCTGAGGA	0.607000													29	64					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060837	9060837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9060837G>A	ENST00000397910.4	-	3	26812	c.26609C>T	c.(26608-26610)tCc>tTc	p.S8870F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8872	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGATGGTGTGGAATAAAGTGG	0.502000													38	83					0	0	1	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228600	57228600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57228600C>T	ENST00000396721.2	-	2	437	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K	SDR16C5_ENST00000522671.1_Missense_Mutation_p.E103K|SDR16C5_ENST00000303749.3_Missense_Mutation_p.E103K			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	103					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						TACACTCCTTCCTTTTGGCTG	0.448000													35	113					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606458	55606458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55606458C>T	ENST00000378396.1	+	1	231	c.231C>T	c.(229-231)tcC>tcT	p.S77S		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				GCTATTCCTCCATCATTGCTC	0.398000													90	231					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41725476	41725476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41725476G>A	ENST00000400454.1	-	5	1327	c.850C>T	c.(850-852)Cgc>Tgc	p.R284C		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	284	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCCGAGGGGCGAATGTTCTCA	0.542000													26	84					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85926837	85926837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:85926837G>A	ENST00000304195.3	-	8	944	c.738C>T	c.(736-738)gtC>gtT	p.V246V	FRMD3_ENST00000376434.1_Silent_p.V52V|FRMD3_ENST00000376438.1_Silent_p.V246V	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	246	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						TTCCCTGAAAGACCACAAAGC	0.353000													21	61					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72297607	72297607	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72297607G>A	ENST00000263563.6	+	11	1536	c.1268G>A	c.(1267-1269)tGg>tAg	p.W423*		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		AGGGCGCTGTGGAGCCTGGAG	0.607000													20	76					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67028325	67028325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67028325C>T	ENST00000340001.4	-	10	1580	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K	ABCA9_ENST00000453985.2_Missense_Mutation_p.E457K|ABCA9_ENST00000370732.2_Missense_Mutation_p.E457K	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	457					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GAATCTGTTTCATTCTCAAGG	0.413000													36	74					0	0	1	0	0
TMEM26	219623	broad.mit.edu	37	10	63173294	63173294	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:63173294C>T	ENST00000399298.3	-	5	974		c.e5-1		TMEM26_ENST00000507507.1_5'UTR	NM_178505.6	NP_848600.2	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26							integral to membrane				kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	18	Prostate(12;0.0112)					AGGACTATTCCTAGAATACAG	0.363000													19	43					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64056670	64056670	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64056670C>T	ENST00000411458.1	+	9	1289	c.1261C>T	c.(1261-1263)Ccc>Tcc	p.P421S	GPR137_ENST00000539851.1_3'UTR|GPR137_ENST00000313074.3_Missense_Mutation_p.P363S|GPR137_ENST00000438980.2_3'UTR|GPR137_ENST00000377702.4_3'UTR	NM_001170726.1	NP_001164197.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	363						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						CAGACGTGATCCCCCTCCCTC	0.647000													30	76					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6948179	6948179	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6948179C>T	ENST00000251761.8	+	0	1954				LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						GGTGCGTCCTCGCTGTGGGCG	0.657000													10	26					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54604068	54604068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54604068G>A	ENST00000474759.1	+	8	873	c.825G>A	c.(823-825)gcG>gcA	p.A275A	CACNA2D3_ENST00000415676.2_Silent_p.A275A|CACNA2D3_ENST00000288197.5_Silent_p.A275A|CACNA2D3_ENST00000490478.1_Silent_p.A181A	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	275	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGACTATCGCGAAGCAAACAG	0.473000													51	108					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5222727	5222727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5222727G>A	ENST00000372412.4	-	18	3312	c.3079C>T	c.(3079-3081)Cgc>Tgc	p.R1027C	PTPRS_ENST00000348075.2_Missense_Mutation_p.R1004C|PTPRS_ENST00000587303.1_Missense_Mutation_p.R1026C|PTPRS_ENST00000588012.1_Missense_Mutation_p.R1004C|PTPRS_ENST00000588552.1_Intron|PTPRS_ENST00000353284.2_Intron|PTPRS_ENST00000262963.6_Missense_Mutation_p.R1022C|PTPRS_ENST00000592099.1_Intron|PTPRS_ENST00000357368.4_Missense_Mutation_p.R1026C			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1026	Fibronectin type-III 7.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GTCCGGTAGCGGACGGGGGGG	0.746000													5	21					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220494888	220494888	+	Missense_Mutation	SNP	C	C	T	rs139813777		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220494888C>T	ENST00000358055.3	+	6	1137	c.625C>T	c.(625-627)Cgg>Tgg	p.R209W	SLC4A3_ENST00000273063.6_Missense_Mutation_p.R236W|SLC4A3_ENST00000373760.2_Missense_Mutation_p.R209W|SLC4A3_ENST00000497589.1_Intron|SLC4A3_ENST00000373762.3_Missense_Mutation_p.R236W|SLC4A3_ENST00000317151.3_Missense_Mutation_p.R209W			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	209					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCAGCCCCCGGGCCCGGGC	0.697000													3	14					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176022630	176022630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176022630G>A	ENST00000510636.1	+	32	4164	c.3890G>A	c.(3889-3891)gGg>gAg	p.G1297E	CDHR2_ENST00000261944.5_Missense_Mutation_p.G1297E|CDHR2_ENST00000506348.1_Missense_Mutation_p.G1297E	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	1297					homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding	p.G1297E(1)		breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CAGCTGGAGGGGCCATCCTAC	0.642000													45	104					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155171641	155171641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:155171641G>A	ENST00000262640.6	+	7	704	c.621G>A	c.(619-621)aaG>aaA	p.K207K	VAMP7_ENST00000286448.6_3'UTR|VAMP7_ENST00000460621.1_3'UTR	NM_001185183.1	NP_001172112.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	0					calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CATTAACCAAGGATATGAGAG	0.413000													11	48					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19195023	19195023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19195023G>A	ENST00000562034.1	+	3	4120	c.322G>A	c.(322-324)Gac>Aac	p.D108N	SYT17_ENST00000355377.2_Missense_Mutation_p.D169N|SYT17_ENST00000568115.1_Missense_Mutation_p.D108N|SYT17_ENST00000562711.2_Missense_Mutation_p.D165N			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	169						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						CTCCAACAGCGACGATGTGGA	0.562000													17	56					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15726098	15726098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15726098G>A	ENST00000378076.3	-	4	826	c.473C>T	c.(472-474)aCt>aTt	p.T158I		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	158					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CGGTTTAAGAGTTCTCCAGTG	0.408000													5	69					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130286841	130286841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130286841C>T	ENST00000257359.6	-	3	1796	c.1090G>A	c.(1090-1092)Gaa>Aaa	p.E364K		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	364	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TTACCTAGTTCATGGGCCAGG	0.572000													75	166					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70946800	70946800	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70946800C>T	ENST00000334414.6	-	21	5188	c.5143_splice	c.e21-1	p.G1715_splice	PTPRB_ENST00000550857.1_Splice_Site_p.G1407_splice|PTPRB_ENST00000451516.2_Intron|PTPRB_ENST00000550358.1_Splice_Site_p.G1627_splice|PTPRB_ENST00000538708.1_Splice_Site_p.G1407_splice|PTPRB_ENST00000261266.5_Splice_Site_p.G1497_splice	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1497	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCATCACTGCCTGGAGGAGA	0.468000													32	128					0	0	1	0	0
AMZ2	51321	broad.mit.edu	37	17	66251903	66251903	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66251903C>T	ENST00000359904.3	+	6	1945	c.813C>T	c.(811-813)ctC>ctT	p.L271L	AMZ2_ENST00000359783.4_Silent_p.L213L|AMZ2_ENST00000577985.1_Silent_p.L271L|AMZ2_ENST00000580753.1_Silent_p.L271L|AMZ2_ENST00000392720.2_Silent_p.L271L|AMZ2_ENST00000577273.1_Intron|AMZ2_ENST00000585050.1_Intron|AMZ2_ENST00000577866.1_Silent_p.L271L	NM_016627.4	NP_057711.3	Q86W34	AMZ2_HUMAN	archaelysin family metallopeptidase 2	271							metallopeptidase activity|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	9	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			TTGCATGCCTCATGCAAGGCT	0.498000													42	84					0	0	1	0	0
APMAP	57136	broad.mit.edu	37	20	24959427	24959427	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:24959427G>A	ENST00000217456.2	-	3	594	c.304C>T	c.(304-306)Ccg>Tcg	p.P102S	APMAP_ENST00000447138.1_Missense_Mutation_p.P102S	NM_020531.2	NP_065392.1			adipocyte plasma membrane associated protein																		ATGGACTCCGGTCCAACAAGT	0.537000													25	59					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21235097	21235097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21235097G>A	ENST00000233242.1	-	26	4770	c.4643C>T	c.(4642-4644)tCt>tTt	p.S1548F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1548					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGCAGATCAGAGGTGGAGGT	0.433000													25	89					0	0	1	0	0
DMBX1	127343	broad.mit.edu	37	1	46978120	46978120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46978120C>T	ENST00000371956.4	+	4	1118	c.1103C>T	c.(1102-1104)gCc>gTc	p.A368V	DMBX1_ENST00000360032.3_Missense_Mutation_p.A363V	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	368					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					CGGCTCCGGGCCAAGCAGCAC	0.637000													12	119					0	0	1	0	0
EFHC2	80258	broad.mit.edu	37	X	44202802	44202802	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:44202802G>A	ENST00000420999.1	-	1	116	c.33C>T	c.(31-33)ttC>ttT	p.F11F		NM_025184.3	NP_079460.2	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	11							calcium ion binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						CGTTGCGGTTGAAGCTGTTGC	0.687000													3	1					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139221945	139221945	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139221945C>T	ENST00000274710.3	+	15	2407	c.2202C>T	c.(2200-2202)gcC>gcT	p.A734A		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	734					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGGCTGGCCACTCTGGAAG	0.552000													22	61					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342998	29342998	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29342998G>A	ENST00000396806.3	-	1	70	c.67C>T	c.(67-69)Cct>Tct	p.P23S	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						AAGAAGAAAGGCTGCAGCTCC	0.393000													23	48					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31540725	31540725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31540725C>T	ENST00000454783.1	+	3	378	c.120C>T	c.(118-120)ctC>ctT	p.L40L	LTA_ENST00000418386.2_Silent_p.L40L	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	40					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	GTGTTGGCCTCACACCTTCAG	0.607000													5	51					0	0	1	0	0
FBXO2	26232	broad.mit.edu	37	1	11710068	11710068	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11710068G>A	ENST00000354287.4	-	3	796	c.455C>T	c.(454-456)cCt>cTt	p.P152L		NM_012168.5	NP_036300.2	Q9UK22	FBX2_HUMAN	F-box protein 2	152	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity			kidney(1)|large_intestine(1)|lung(4)	6	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		ACTGTCTCCAGGCAGCTCCTC	0.612000													14	196					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156269057	156269057	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156269057C>T	ENST00000311277.4	-	14	2085	c.1821_splice	c.e14-1	p.E608_splice	MAP9_ENST00000515654.1_Splice_Site_p.E584_splice|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000597939.1_RNA|AC097467.2_ENST00000595229.1_RNA|AC097467.2_ENST00000601977.1_RNA|AC097467.2_ENST00000593387.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	608					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TCCTTATTTTCCTAAAGAGAA	0.328000													3	7					0	0	1	0	0
GOLGA8IP	283796	broad.mit.edu	37	15	23261824	23261824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23261824G>A	ENST00000450802.3	+	12	1034	c.936G>A	c.(934-936)agG>agA	p.R312R																								AGCACCTGAGGAAGGAACTAG	0.577000													18	92					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65129479	65129479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:65129479C>T	ENST00000371073.2	+	14	2053	c.2053C>T	c.(2053-2055)Ctc>Ttc	p.L685F	CACHD1_ENST00000290039.5_Missense_Mutation_p.L634F|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	685					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CACCGCCTATCTCAGCGACAA	0.587000													34	163					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38964208	38964208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38964208G>A	ENST00000355481.4	+	28	4088	c.3957G>A	c.(3955-3957)gaG>gaA	p.E1319E	RYR1_ENST00000360985.3_Silent_p.E1319E|RYR1_ENST00000359596.3_Silent_p.E1319E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1319	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCCCGCCGAGGACGAGGCCC	0.692000													3	3					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176787	140176787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140176787G>A	ENST00000526136.1	+	1	2238	c.2238G>A	c.(2236-2238)ggG>ggA	p.G746G	PCDHA2_ENST00000378132.1_Silent_p.G746G|PCDHA2_ENST00000520672.2_Silent_p.G746G|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCCGTGGGGAGCTGGTCTT	0.672000													35	67					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24835007	24835007	+	Silent	SNP	G	G	A	rs78374720		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24835007G>A	ENST00000376454.3	+	21	5616	c.5586G>A	c.(5584-5586)ttG>ttA	p.L1862L	KIAA1217_ENST00000458595.1_Silent_p.L1268L|KIAA1217_ENST00000376462.1_Silent_p.L1183L|KIAA1217_ENST00000396445.1_3'UTR|KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000376452.3_Silent_p.L1293L	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1862	Ser-rich.				embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						ATGGCTCTTTGAAGTTTCAGA	0.502000													52	113					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34312544	34312544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34312544C>T	ENST00000373381.4	-	6	1150	c.974G>A	c.(973-975)cGa>cAa	p.R325Q		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	285						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GAAGTGCAGTCGCAGCCAGTT	0.612000													21	47					0	0	1	0	0
CD3D	915	broad.mit.edu	37	11	118211307	118211307	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118211307C>T	ENST00000300692.4	-	2	193	c.55_splice	c.e2-1	p.V19_splice	CD3D_ENST00000529594.1_Intron|CD3D_ENST00000392884.2_Splice_Site_p.V19_splice	NM_000732.4	NP_000723.1	P04234	CD3D_HUMAN	CD3d molecule, delta (CD3-TCR complex)	19					positive thymic T cell selection|T cell costimulation|T cell receptor signaling pathway	cytoplasm|integral to membrane	protein heterodimerization activity			large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	9	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		TGAAGGGGCTCACTAAAGGGG	0.463000													8	23					0	0	1	0	0
ATHL1	80162	broad.mit.edu	37	11	291051	291051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:291051C>T	ENST00000409548.2	+	4	959	c.844C>T	c.(844-846)Cct>Tct	p.P282S	ATHL1_ENST00000409655.1_Missense_Mutation_p.P105S|ATHL1_ENST00000409479.1_Missense_Mutation_p.P282S	NM_025092.4	NP_079368.3	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1 (yeast)	282					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|skin(3)	17		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		TGGCCTCAGTCCTGGGGGCCT	0.662000													23	34					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69949067	69949067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:69949067C>T	ENST00000370598.1	+	20	3584	c.2763C>T	c.(2761-2763)atC>atT	p.I921I	BAI3_ENST00000238918.8_Silent_p.I127I	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	921					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GCCTGTCTATCATCTCATCCA	0.353000													48	97					0	0	1	0	0
GPCPD1	56261	broad.mit.edu	37	20	5528378	5528378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5528378G>A	ENST00000379019.4	-	20	2160	c.1948C>T	c.(1948-1950)Ccc>Tcc	p.P650S	GPCPD1_ENST00000481038.1_5'UTR	NM_019593.3	NP_062539.1	Q9NPB8	GPCP1_HUMAN	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	650					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)	16						AAAGATGAGGGAACAAAGCGG	0.458000													66	132					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13830199	13830199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13830199G>A	ENST00000265104.4	-	37	6289	c.6185C>T	c.(6184-6186)tCt>tTt	p.S2062F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2062	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AAAGATAAAAGACTTTTTGTG	0.383000									Kartagener syndrome				13	56					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151167023	151167023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151167023G>A	ENST00000282466.3	-	4	745	c.746C>T	c.(745-747)cCc>cTc	p.P249L		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	249	LRRCT.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGCACTAGAGGGACTTCTATC	0.398000													29	63					0	0	1	0	0
CHAD	1101	broad.mit.edu	37	17	48545818	48545818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48545818G>A	ENST00000508540.1	-	1	509	c.357C>T	c.(355-357)ttC>ttT	p.F119F	ACSF2_ENST00000504392.1_Intron|CHAD_ENST00000258969.4_Silent_p.F119F|ACSF2_ENST00000427954.2_Intron|ACSF2_ENST00000541920.1_Intron|ACSF2_ENST00000300441.4_Intron|ACSF2_ENST00000506085.1_Intron|ACSF2_ENST00000502667.1_Intron	NM_001267.2	NP_001258.2	O15335	CHAD_HUMAN	chondroadherin	119					regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(2)|ovary(2)	15	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TCAGGTCGTCGAAGGCACCTG	0.617000													8	83					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54647985	54647985	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54647985A>T	ENST00000406403.1	+	6	2003	c.400A>T	c.(400-402)Acg>Tcg	p.T134S	CNOT3_ENST00000221232.5_Missense_Mutation_p.T134S|CNOT3_ENST00000358389.3_De_novo_Start_InFrame			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	134					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TACCATCGACACGCTCAACAT	0.557000													17	28					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12726382	12726382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12726382C>T	ENST00000376221.1	+	4	860	c.860C>T	c.(859-861)cCt>cTt	p.P287L		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	287						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TGGCTCAGCCCTGACAACATC	0.512000													47	106					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69758135	69758135	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:69758135G>A	ENST00000370598.1	+	14	2987	c.2166G>A	c.(2164-2166)atG>atA	p.M722I		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	722					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.M722I(1)		NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ACTTTCCAATGAAAGGACGGA	0.368000													36	62					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21196326	21196326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21196326C>T	ENST00000381541.3	+	7	851	c.786C>T	c.(784-786)ttC>ttT	p.F262F	LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Silent_p.F215F|SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000554957.1_Silent_p.F262F																							GGCTTGGTTTCCTTGTGTCTG	0.353000													54	173					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965048	88965048	+	Missense_Mutation	SNP	G	G	A	rs144693443	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:88965048G>A	ENST00000333190.4	+	4	3361	c.2752G>A	c.(2752-2754)Gga>Aga	p.G918R		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	918						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CACTGCAGAAGGAGAGAGGAC	0.423000										HNSCC(36;0.09)			25	120					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98743903	98743903	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98743903C>T	ENST00000286067.2	+	1	2863	c.2756C>T	c.(2755-2757)tCa>tTa	p.S919L		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	919										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TATCCCAGTTCACTACAGGCT	0.468000													38	84					0	0	1	0	0
KRT33B	3884	broad.mit.edu	37	17	39522755	39522755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39522755C>T	ENST00000251646.3	-	3	604	c.555G>A	c.(553-555)gaG>gaA	p.E185E		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	185	Coil 1B.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				ACAGCAGCTCCTCCTTCAGGG	0.567000													6	76					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54841886	54841886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54841886G>A	ENST00000545554.1	+	27	5874	c.5874G>A	c.(5872-5874)ctG>ctA	p.L1958L	UNC13C_ENST00000537900.1_Silent_p.L1956L|UNC13C_ENST00000260323.11_Silent_p.L1958L			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1958	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TATCCAAACTGAAGGTAATAA	0.358000													41	83					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128957988	128957988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128957988G>A	ENST00000274487.4	+	10	1844	c.1699G>A	c.(1699-1701)Gaa>Aaa	p.E567K	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	567	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CACTGCTGATGAACAATGCCA	0.463000													20	60					0	0	1	0	0
THNSL1	79896	broad.mit.edu	37	10	25313252	25313252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25313252C>T	ENST00000524413.1	+	3	1447	c.1100C>T	c.(1099-1101)cCa>cTa	p.P367L	THNSL1_ENST00000376356.4_Missense_Mutation_p.P367L			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	367					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	CACTGTATCCCACCAAGTTGC	0.388000													36	114					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64668705	64668705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:64668705G>A	ENST00000543942.2	-	11	2186	c.1560C>T	c.(1558-1560)tcC>tcT	p.S520S	C12orf56_ENST00000333722.5_Silent_p.S360S|RPS11P6_ENST00000535684.1_RNA|C12orf56_ENST00000536975.1_5'UTR	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	523										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		TTTGTAGAAAGGACATTATCC	0.353000													18	72					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42145615	42145615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42145615G>A	ENST00000502486.1	-	3	1463	c.884C>T	c.(883-885)tCc>tTc	p.S295F	BEND4_ENST00000504360.1_Missense_Mutation_p.S291F	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	295										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						CGTTGCTGGGGAAGTCCAGCC	0.552000													5	13					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169701980	169701980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169701980G>A	ENST00000333360.7	-	3	336	c.197C>T	c.(196-198)tCa>tTa	p.S66L	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367775.1_Missense_Mutation_p.S66L|SELE_ENST00000367774.1_Missense_Mutation_p.S66L|SELE_ENST00000367782.4_Missense_Mutation_p.S66L|SELE_ENST00000367779.4_Missense_Mutation_p.S66L|SELE_ENST00000367781.4_Missense_Mutation_p.S66L|SELE_ENST00000367777.1_Missense_Mutation_p.S66L|SELE_ENST00000367776.1_Missense_Mutation_p.S66L|SELE_ENST00000367780.4_Missense_Mutation_p.S66L	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	66	C-type lectin.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					ATAACTTGGTGAATAGCTCAA	0.428000													23	79					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152804	18152804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18152804C>T	ENST00000375406.1	+	3	1107	c.891C>T	c.(889-891)gcC>gcT	p.A297A		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	297						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		ACGTGATGGCCTGCGGGGGCA	0.647000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	66					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144994716	144994716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:144994716G>A	ENST00000369356.4	-	1	306	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C	PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369347.4_Missense_Mutation_p.R6C|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R6C|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.R6C|PDE4DIP_ENST00000530740.1_Intron	NM_001198834.2|NM_014644.4	NP_001185763.2|NP_055459.4	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	6					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GACAGAGTGCGATATCCATTA	0.567000			T	PDGFRB	MPD								11	125					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119942978	119942978	+	Silent	SNP	G	G	A	rs141348508	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119942978G>A	ENST00000327554.2	+	7	1218	c.753G>A	c.(751-753)caG>caA	p.Q251Q	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	251										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCTCTCCCCAGAGCAGCATGA	0.557000													69	147					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55815961	55815961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55815961G>A	ENST00000309383.1	+	14	1667	c.1390G>A	c.(1390-1392)Gag>Aag	p.E464K	BRSK1_ENST00000590333.1_Missense_Mutation_p.E480K|BRSK1_ENST00000326848.7_Missense_Mutation_p.E159K|BRSK1_ENST00000588584.1_3'UTR	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	464					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GGCTGGAGATGAGGCTCGAGG	0.672000													11	14					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10534239	10534239	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10534239C>T	ENST00000396560.2	+	6	1341	c.1114C>T	c.(1114-1116)Caa>Taa	p.Q372*	ATF7IP2_ENST00000356427.2_Nonsense_Mutation_p.Q372*|ATF7IP2_ENST00000396559.1_Nonsense_Mutation_p.Q372*|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000324570.5_Nonsense_Mutation_p.Q372*	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						AGCAAAACTTCAAAGACGTAT	0.299000													4	32					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22171710	22171710	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22171710C>T	ENST00000397126.4	-	2	153	c.3_splice	c.e2-1	p.G2_splice	ZNF208_ENST00000599916.1_Splice_Site_p.G2_splice|ZNF208_ENST00000597040.1_5'UTR|ZNF208_ENST00000601773.1_Splice_Site_p.G2_splice	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGTCAATGATCCCTGGAAAAC	0.403000													52	156					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6065875	6065875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6065875C>T	ENST00000217289.4	-	12	2219	c.1431G>A	c.(1429-1431)atG>atA	p.M477I	FERMT1_ENST00000536936.1_Missense_Mutation_p.M220I|FERMT1_ENST00000478194.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	477	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						AGCTGTCTGCCATGGTTTTGC	0.493000													17	64					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25228723	25228723	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:25228723G>A	ENST00000219660.5	+	2	342	c.217G>A	c.(217-219)Ggg>Agg	p.G73R	AQP8_ENST00000566125.1_Missense_Mutation_p.G67R	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	73					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		CCTGGCCCACGGGCTGGCTTT	0.607000													12	197					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56092314	56092314	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56092314C>T	ENST00000257880.7	-	8	1396	c.1177G>A	c.(1177-1179)Gaa>Aaa	p.E393K	ITGA7_ENST00000553804.1_Missense_Mutation_p.E353K|ITGA7_ENST00000394229.2_Missense_Mutation_p.E349K|ITGA7_ENST00000394230.2_Missense_Mutation_p.E353K|ITGA7_ENST00000347027.6_Missense_Mutation_p.E349K|ITGA7_ENST00000257879.6_Missense_Mutation_p.E349K|ITGA7_ENST00000555728.1_Missense_Mutation_p.E393K|ITGA7_ENST00000452168.2_Missense_Mutation_p.E256K			Q13683	ITA7_HUMAN	integrin, alpha 7	393					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCCAGCTCTTCTTGGCGCTCA	0.612000													38	71					0	0	1	0	0
PRIMA1	145270	broad.mit.edu	37	14	94203637	94203637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94203637G>A	ENST00000393140.1	-	4	411	c.309C>T	c.(307-309)tcC>tcT	p.S103S	PRIMA1_ENST00000316227.3_Silent_p.S103S|PRIMA1_ENST00000393143.1_Silent_p.S103S	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	103					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		GAAACACCAGGGAGGCACAGC	0.537000													13	44					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104122736	104122736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104122736C>T	ENST00000388887.2	+	48	5249	c.5045C>T	c.(5044-5046)tCc>tTc	p.S1682F		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1682	FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AATGCTACTTCCCTCCAAGGA	0.498000													32	83					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41581076	41581076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41581076C>T	ENST00000396942.1	-	8	870	c.787G>A	c.(787-789)Gcc>Acc	p.A263T	ANK1_ENST00000352337.4_Missense_Mutation_p.A263T|ANK1_ENST00000396945.1_Missense_Mutation_p.A263T|ANK1_ENST00000289734.7_Missense_Mutation_p.A263T|ANK1_ENST00000379758.2_Missense_Mutation_p.A263T|ANK1_ENST00000265709.8_Missense_Mutation_p.A296T|ANK1_ENST00000347528.4_Missense_Mutation_p.A263T			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	263	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTATCTGGGCTCCCCGATCC	0.652000													22	100					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821061	43821061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43821061G>A	ENST00000417669.1	+	2	514	c.70G>A	c.(70-72)Ggc>Agc	p.G24S	MPPED1_ENST00000443721.1_Missense_Mutation_p.G24S|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000542779.1_Missense_Mutation_p.G24S|MPPED1_ENST00000538182.1_Missense_Mutation_p.G57S			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	24							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				CTGCGGCCTGGGCATGGCATT	0.701000													18	19					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73554625	73554625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73554625C>T	ENST00000392550.3	+	5	405	c.288C>T	c.(286-288)agC>agT	p.S96S	LLGL2_ENST00000577200.1_Silent_p.S96S|LLGL2_ENST00000375227.4_Silent_p.S96S|LLGL2_ENST00000578363.1_Silent_p.S96S|LLGL2_ENST00000167462.5_Silent_p.S96S	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	96					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			ATGACAACAGCCTGCACCTTT	0.622000													12	14					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106118213	106118213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106118213G>A	ENST00000369704.3	+	2	258	c.124G>A	c.(124-126)Gaa>Aaa	p.E42K	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	42										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ATTTCGGATTGAATATGAGAG	0.388000													16	53					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35786520	35786520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35786520C>T	ENST00000361922.4	+	4	201	c.51C>T	c.(49-51)tcC>tcT	p.S17S	MAG_ENST00000392213.3_Silent_p.S17S|MAG_ENST00000597035.1_Silent_p.S17S|MAG_ENST00000537831.2_5'UTR	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	17					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCGCAGCCTCCCGAGGGGGTC	0.687000													25	47					0	0	1	0	0
FAM149A	25854	broad.mit.edu	37	4	187086556	187086556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187086556C>T	ENST00000356371.5	+	11	1975	c.1975C>T	c.(1975-1977)Ccc>Tcc	p.P659S	FAM149A_ENST00000514153.1_Missense_Mutation_p.P368S|FAM149A_ENST00000503432.1_Missense_Mutation_p.P368S|FAM149A_ENST00000502970.1_Missense_Mutation_p.P368S|FAM149A_ENST00000389354.5_Missense_Mutation_p.P368S|FAM149A_ENST00000227065.4_Missense_Mutation_p.P368S			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	659										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		GAGCAGGTTCCCCCCGCTAGT	0.537000													19	60					0	0	1	0	0
NR4A3	8013	broad.mit.edu	37	9	102609857	102609857	+	Silent	SNP	C	C	T	rs145134236	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:102609857C>T	ENST00000330847.1	+	6	1670	c.1626C>T	c.(1624-1626)atC>atT	p.I542I	NR4A3_ENST00000395097.2_Silent_p.I531I			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	531					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				ACCTTGATATCCAAGCCTTAG	0.483000			T	EWSR1	extraskeletal myxoid chondrosarcoma								7	79					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729258	62729258	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62729258C>T	ENST00000349451.3	+	5	749	c.337C>T	c.(337-339)Ctg>Ttg	p.L113L	OPRL1_ENST00000336866.2_Silent_p.L113L|OPRL1_ENST00000355631.4_Silent_p.L113L	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	113					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GGACATCCTCCTGGGCTTCTG	0.532000													60	103					0	0	1	0	0
CDAN1	146059	broad.mit.edu	37	15	43026533	43026533	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43026533T>C	ENST00000356231.3	-	7	1171	c.1148A>G	c.(1147-1149)aAc>aGc	p.N383S		NM_138477.2	NP_612486.2	Q8IWY9	CDAN1_HUMAN	codanin 1	383						integral to membrane	protein binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	24		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		TTTGTCCAGGTTGGAAAGAAC	0.557000													15	43					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219483369	219483369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219483369G>A	ENST00000450993.2	+	4	588	c.249G>A	c.(247-249)gaG>gaA	p.E83E	PLCD4_ENST00000432688.1_Silent_p.E83E|PLCD4_ENST00000417849.1_Silent_p.E83E	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	83	PH.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GCCTGGCAGAGGAGCTCCCCC	0.557000													18	38					0	0	1	0	0
OCM	654231	broad.mit.edu	37	7	5925699	5925699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5925699C>T	ENST00000242104.5	+	4	401	c.309C>T	c.(307-309)ttC>ttT	p.F103F	OCM_ENST00000416608.1_Silent_p.F103F	NM_001097622.1	NP_001091091.1	P0CE72	ONCO_HUMAN	oncomodulin	103	EF-hand 2.						calcium ion binding			endometrium(1)|large_intestine(3)|lung(2)	6		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		TTCTAGAATTCCAGGAAATGG	0.493000													23	52					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332825	70332825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70332825C>T	ENST00000338508.4	-	32	3575	c.3576G>A	c.(3574-3576)gcG>gcA	p.A1192A	SHANK2_ENST00000449833.2_Silent_p.A596A|SHANK2_ENST00000423696.2_Silent_p.A812A|SHANK2_ENST00000409161.1_Silent_p.A595A			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	812					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding	p.A596A(1)|p.A1192A(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGCCGCTGCTCGCGGAGGGCA	0.706000													19	64					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120795706	120795706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:120795706G>A	ENST00000369144.3	-	22	4121	c.3994C>T	c.(3994-3996)Ccc>Tcc	p.P1332S	EIF3A_ENST00000541549.1_Missense_Mutation_p.P1298S|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1332					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AGAGCTGGGGGAGGAACTCGA	0.463000													20	100					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238272008	238272008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238272008C>T	ENST00000295550.4	-	14	6403	c.5951G>A	c.(5950-5952)cGa>cAa	p.R1984Q	COL6A3_ENST00000409809.1_Missense_Mutation_p.R1778Q|COL6A3_ENST00000472056.1_Missense_Mutation_p.R1377Q|COL6A3_ENST00000346358.4_Missense_Mutation_p.R1784Q|COL6A3_ENST00000353578.4_Missense_Mutation_p.R1778Q|COL6A3_ENST00000347401.3_Missense_Mutation_p.R1783Q	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1984	Nonhelical region.|VWFA 10.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTTGACCACTCGTTCAAGGCC	0.478000													16	69					0	0	1	0	0
TTLL13	440307	broad.mit.edu	37	15	90799405	90799405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90799405G>A	ENST00000438251.1	+	6	871	c.581G>A	c.(580-582)cGa>cAa	p.R194Q	RP11-697E2.6_ENST00000561573.1_Intron|TTLL13_ENST00000339615.5_Missense_Mutation_p.R194Q			A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	194	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	16	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GGTCGTCAGCGAAAAGCCCGC	0.557000													29	135					0	0	1	0	0
CDH19	28513	broad.mit.edu	37	18	64202268	64202268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:64202268C>T	ENST00000262150.2	-	8	1583	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K	CDH19_ENST00000540086.1_Missense_Mutation_p.E431K	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	431	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				GCACTGATTTCACGATCCAGT	0.328000													14	66					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23901876	23901876	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23901876G>A	ENST00000355349.3	-	5	636	c.474C>T	c.(472-474)tcC>tcT	p.S158S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	158	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGGCGTTGTCGGAGATGGAGA	0.607000													76	141					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111766711	111766711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111766711C>T	ENST00000452346.2	+	7	859	c.856C>T	c.(856-858)Cgt>Tgt	p.R286C	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.R160C			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	286	CUB 1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CTACCTGATTCGTCTCTCAAT	0.527000													27	43					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24834974	24834974	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24834974C>T	ENST00000376454.3	+	21	5583	c.5553C>T	c.(5551-5553)gcC>gcT	p.A1851A	KIAA1217_ENST00000458595.1_Silent_p.A1257A|KIAA1217_ENST00000376462.1_Silent_p.A1172A|KIAA1217_ENST00000396445.1_3'UTR|KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000376452.3_Silent_p.A1282A	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1851	Ser-rich.				embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTCACTCTGCCTCCCTCATCC	0.493000													29	144					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394269	233394269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233394269C>T	ENST00000258229.8	-	5	1573	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	447						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CCATTGCCTTCGGGACAGGGA	0.567000													55	93					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52604151	52604151	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52604151T>A	ENST00000591504.1	-	6	658	c.384A>T	c.(382-384)agA>agT	p.R128S	CCDC68_ENST00000432185.1_Missense_Mutation_p.R128S|CCDC68_ENST00000337363.4_Missense_Mutation_p.R128S	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	128										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		GGGCCACGTTTCTCAGAGCTG	0.428000													9	82					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98209632	98209632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:98209632G>A	ENST00000430669.2	-	23	4293	c.3708C>T	c.(3706-3708)ccC>ccT	p.P1236P	PTCH1_ENST00000331920.6_Silent_p.P1302P|PTCH1_ENST00000375274.2_Silent_p.P1301P|PTCH1_ENST00000437951.1_Silent_p.P1236P|PTCH1_ENST00000421141.1_Silent_p.P1151P|PTCH1_ENST00000429896.2_Silent_p.P1151P|PTCH1_ENST00000418258.1_Silent_p.P1151P			Q13635	PTC1_HUMAN	patched 1	1302					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.P1302H(2)		NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GGTCCCTGCGGGGCTGCTGGC	0.632000													27	69					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17588655	17588655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17588655G>A	ENST00000375460.3	+	3	341	c.301G>A	c.(301-303)Gag>Aag	p.E101K		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	101					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CTCCAGCCATGAGCCTCTGCC	0.547000													15	29					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47777887	47777887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47777887C>T	ENST00000398545.4	-	4	858	c.741G>A	c.(739-741)gcG>gcA	p.A247A		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	247										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GCAGCTGTGTCGCCTGCCTTT	0.557000													28	66					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1891351	1891351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1891351G>A	ENST00000399161.2	-	17	3298	c.2551C>T	c.(2551-2553)Cta>Tta	p.L851L	MYT1L_ENST00000428368.2_Silent_p.L849L	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	851					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTTTCTTCTAGAGCCTCCTGG	0.527000													27	140					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69682041	69682041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69682041G>A	ENST00000265403.7	+	1	331	c.304G>A	c.(304-306)Gat>Aat	p.D102N	UGT2B10_ENST00000458688.2_Missense_Mutation_p.D102N	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	102					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						AATTCAAAAAGATACATTTTG	0.289000													28	97					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27197330	27197330	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27197330G>A	ENST00000380036.4	+	12	2084	c.1642G>A	c.(1642-1644)Ggt>Agt	p.G548S	TEK_ENST00000519097.1_Missense_Mutation_p.G401S|TEK_ENST00000406359.4_Missense_Mutation_p.G505S	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	548	Fibronectin type-III 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TCCTCCAAGAGGTCTAAATCT	0.398000													32	86					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30966408	30966408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:30966408G>A	ENST00000295055.8	-	13	1462	c.1286C>T	c.(1285-1287)tCg>tTg	p.S429L	CAPN13_ENST00000534090.2_Missense_Mutation_p.S429L	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	429					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GTTTCTGAACGAGGAAAAAAA	0.473000													10	88					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739037	38739037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38739037C>T	ENST00000449082.2	-	27	5673	c.5674G>A	c.(5674-5676)Gaa>Aaa	p.E1892K		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1892					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACAAAACCTTCATCTGGGAGT	0.502000													53	94					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102175092	102175092	+	Missense_Mutation	SNP	G	G	A	rs149996665		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:102175092G>A	ENST00000306176.1	+	4	531	c.431G>A	c.(430-432)gGa>gAa	p.G144E	ZPLD1_ENST00000491959.1_Missense_Mutation_p.G128E|ZPLD1_ENST00000466937.1_Missense_Mutation_p.G128E	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	128	ZP.					integral to membrane		p.G144E(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GTGCAAGTAGGAAATATTTCA	0.358000													48	102					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43627933	43627933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:43627933C>T	ENST00000378069.4	-	14	1525	c.1378G>A	c.(1378-1380)Gat>Aat	p.D460N	MAOB_ENST00000536181.1_Missense_Mutation_p.D444N|MAOB_ENST00000538942.1_Missense_Mutation_p.G411E	NM_000898.4	NP_000889.3	P27338	AOFB_HUMAN	monoamine oxidase B	460					xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(2)|skin(5)	21					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	CAGATTTCATCCTCTGGAATC	0.398000													23	18					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234072440	234072440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234072440C>T	ENST00000359570.5	+	14	1292	c.1292C>T	c.(1291-1293)cCc>cTc	p.P431L	INPP5D_ENST00000538935.1_Missense_Mutation_p.P430L|INPP5D_ENST00000455936.2_Missense_Mutation_p.P195L|INPP5D_ENST00000450745.1_Missense_Mutation_p.P195L			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	443					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GACTACATCCCCCATGACATT	0.557000													31	138					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48055274	48055274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48055274C>T	ENST00000316364.5	+	9	1159	c.720C>T	c.(718-720)atC>atT	p.I240I	SEMA6D_ENST00000558816.1_Silent_p.I240I|SEMA6D_ENST00000389432.2_Silent_p.I240I|SEMA6D_ENST00000358066.4_Silent_p.I240I|SEMA6D_ENST00000536845.2_Silent_p.I240I|SEMA6D_ENST00000389428.3_Silent_p.I240I|SEMA6D_ENST00000389433.2_Silent_p.I240I|SEMA6D_ENST00000558014.1_Silent_p.I240I|SEMA6D_ENST00000355997.3_Silent_p.I240I|SEMA6D_ENST00000389425.3_Silent_p.I240I|SEMA6D_ENST00000537942.1_Silent_p.I240I|SEMA6D_ENST00000354744.4_Silent_p.I240I	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	240	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTCGAGAAATCGCTGTCGAAC	0.358000													4	34					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33374802	33374802	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:33374802C>T	ENST00000303296.4	+	17	3641	c.3336C>T	c.(3334-3336)ctC>ctT	p.L1112L	HIPK3_ENST00000525975.1_Silent_p.L1091L|HIPK3_ENST00000456517.1_Silent_p.L1091L|HIPK3_ENST00000379016.3_Silent_p.L1091L	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	1112					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						ATACACACCTCGGAGGACAGC	0.507000													16	87					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8483425	8483425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8483425C>T	ENST00000447869.1	-	4	1403	c.485G>A	c.(484-486)cGa>cAa	p.R162Q	STK33_ENST00000358872.3_5'UTR|STK33_ENST00000534493.1_Missense_Mutation_p.R121Q|STK33_ENST00000315204.1_Missense_Mutation_p.R162Q|STK33_ENST00000396673.1_Missense_Mutation_p.R162Q|STK33_ENST00000396672.1_Missense_Mutation_p.R162Q			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	162	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		GTTCACCTCTCGTTCAAGTAA	0.363000													33	84					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115544823	115544823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:115544823G>A	ENST00000310836.6	+	2	1309	c.787G>A	c.(787-789)Gga>Aga	p.G263R	UGT8_ENST00000394511.3_Missense_Mutation_p.G263R	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	263					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TTATGTAGGAGGAATCCTAAC	0.423000													33	72					0	0	1	0	0
TMEM109	79073	broad.mit.edu	37	11	60689298	60689298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60689298C>T	ENST00000227525.3	+	4	796	c.393C>T	c.(391-393)ttC>ttT	p.F131F	RP11-881M11.4_ENST00000543907.1_RNA|TMEM109_ENST00000536171.1_Silent_p.F131F	NM_024092.2	NP_076997.1	Q9BVC6	TM109_HUMAN	transmembrane protein 109	131						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8						TCCAGACCTTCCTGCTGTGGG	0.632000													54	108					0	0	1	0	0
ATG13	9776	broad.mit.edu	37	11	46686987	46686987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:46686987C>T	ENST00000434074.1	+	12	1644	c.955C>T	c.(955-957)Cat>Tat	p.H319Y	ATG13_ENST00000528494.1_Missense_Mutation_p.H352Y|ATG13_ENST00000312040.4_Missense_Mutation_p.H319Y|ATG13_ENST00000359513.4_Missense_Mutation_p.H319Y|ATG13_ENST00000526508.1_Missense_Mutation_p.H319Y|ATG13_ENST00000529655.1_Missense_Mutation_p.H282Y|ATG13_ENST00000524625.1_Missense_Mutation_p.H282Y|ATG13_ENST00000451945.1_Missense_Mutation_p.H282Y|ATG13_ENST00000530500.1_Missense_Mutation_p.H203Y	NM_001205120.1	NP_001192049.1	O75143	ATG13_HUMAN	autophagy related 13	319					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	15						CCAGCCTGTCCATGGTACCCA	0.562000													25	45					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100330034	100330034	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100330034T>C	ENST00000294724.4	+	5	1031	c.553T>C	c.(553-555)Ttt>Ctt	p.F185L	AGL_ENST00000361522.4_Missense_Mutation_p.F168L|AGL_ENST00000370163.3_Missense_Mutation_p.F185L|AGL_ENST00000361915.3_Missense_Mutation_p.F185L|AGL_ENST00000370161.2_Missense_Mutation_p.F169L|AGL_ENST00000361302.3_Missense_Mutation_p.F169L|AGL_ENST00000370165.3_Missense_Mutation_p.F185L	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	185					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		AAATCCTGACTTTTCAAGACC	0.363000													28	116					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179643967	179643967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179643967G>A	ENST00000589042.1	-	23	4176	c.3952C>T	c.(3952-3954)Cca>Tca	p.P1318S	TTN_ENST00000342992.6_Missense_Mutation_p.P1318S|TTN_ENST00000360870.5_Missense_Mutation_p.P1318S|TTN_ENST00000460472.2_Missense_Mutation_p.P1272S|TTN_ENST00000342175.6_Missense_Mutation_p.P1272S|TTN_ENST00000359218.5_Missense_Mutation_p.P1272S|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P1318S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1318	Ig-like 5.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTAATGGATATCCAGAC	0.303000													20	48					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275666	130275666	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130275666G>T	ENST00000257359.6	-	9	3163	c.2457C>A	c.(2455-2457)agC>agA	p.S819R		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	819	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CTCTCTCTTTGCTGCTCTGCA	0.577000													63	191					7.55815e-43	7.61299e-43	1	1	0
CD93	22918	broad.mit.edu	37	20	23066017	23066017	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23066017G>T	ENST00000246006.4	-	1	960	c.813C>A	c.(811-813)tgC>tgA	p.C271*		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	271	EGF-like 1.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					AGTCCTGGTGGCAGCCCCCAT	0.627000													39	114					5.43694e-19	5.46977e-19	1	1	0
CTAG2	30848	broad.mit.edu	37	X	153880896	153880896	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153880896C>T	ENST00000247306.4	-	2	342	c.279G>A	c.(277-279)acG>acA	p.T93T	CTAG2_ENST00000369585.3_Silent_p.T93T	NM_020994.3	NP_066274.1	O75638	CTAG2_HUMAN	cancer/testis antigen 2	93						centrosome				central_nervous_system(1)|endometrium(1)|lung(6)|ovary(1)|pancreas(1)	10	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGAAAGGCATCGTGATGTGCC	0.642000													23	19					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628475	71628475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71628475C>T	ENST00000377276.2	-	1	564	c.534G>A	c.(532-534)caG>caA	p.Q178Q		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	178	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						GCAGGTAGCCCTGCTGGTCGA	0.632000													7	25					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	650775	650775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:650775G>A	ENST00000255622.6	+	9	1263	c.1220G>A	c.(1219-1221)gGg>gAg	p.G407E	PDE6B_ENST00000429163.2_Missense_Mutation_p.G128E|PDE6B_ENST00000496514.1_Missense_Mutation_p.G407E	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	407	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						AGGAAAGACGGGAAGCCCTTT	0.587000													26	51					0	0	1	0	0
NDUFV1	4723	broad.mit.edu	37	11	67379625	67379625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67379625C>T	ENST00000322776.6	+	9	1350	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	NDUFV1_ENST00000532303.1_Silent_p.F298F|NDUFV1_ENST00000529927.1_Silent_p.F390F|NDUFV1_ENST00000415352.2_Silent_p.F392F	NM_001166102.1|NM_007103.3	NP_001159574.1|NP_009034.2	P49821	NDUV1_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	399					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	16					NADH(DB00157)	TGGCACGTTTCGTGAGGGGGG	0.622000													49	102					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119911838	119911838	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119911838T>A	ENST00000464295.1	-	5	867	c.422A>T	c.(421-423)aAg>aTg	p.K141M	GPR156_ENST00000461057.1_Missense_Mutation_p.K141M|GPR156_ENST00000315843.3_Missense_Mutation_p.K141M			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	141						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		TCGCCAGCTCTTTCCCAGAAT	0.512000													20	84					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902356	51902356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:51902356G>A	ENST00000268919.4	+	1	2118	c.1962G>A	c.(1960-1962)gaG>gaA	p.E654E		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	654					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CTCTGACCGAGATCCAAAAGA	0.448000													12	50					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13185134	13185134	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13185134C>T	ENST00000379345.2	+	5	574	c.333C>T	c.(331-333)ttC>ttT	p.F111F	PHACTR1_ENST00000457702.2_Intron|PHACTR1_ENST00000379350.1_Intron|PHACTR1_ENST00000332995.7_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	50						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CTGCTGCTTTCCCTGGAGACC	0.577000													9	119					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150715859	150715859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150715859G>A	ENST00000605938.1	-	6	1641	c.1566C>T	c.(1564-1566)ccC>ccT	p.P522P	ATG9B_ENST00000377974.2_Silent_p.P522P|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_Intron	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	522					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCGTGCGCAGGGGCGCGGGGG	0.741000													3	6					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26586715	26586715	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26586715T>A	ENST00000436318.2	-	2	905	c.772A>T	c.(772-774)Aaa>Taa	p.K258*	ANO3_ENST00000537978.1_Intron|MUC15_ENST00000281268.8_Nonsense_Mutation_p.K258*|MUC15_ENST00000529533.1_Nonsense_Mutation_p.K258*|MUC15_ENST00000455601.2_Nonsense_Mutation_p.K231*|ANO3_ENST00000531568.1_Intron|ANO3_ENST00000256737.3_Intron|ANO3_ENST00000525139.1_Intron|MUC15_ENST00000527569.1_Nonsense_Mutation_p.K258*			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	231						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						TATTTACCTTTTTGGGGATCT	0.338000													23	105					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15600105	15600105	+	Missense_Mutation	SNP	C	C	T	rs138187704		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15600105C>T	ENST00000378076.3	-	26	3087	c.2734G>A	c.(2734-2736)Gaa>Aaa	p.E912K		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	912					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CTGTGGAATTCGACCACATGT	0.498000													33	101					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140227901	140227901	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140227901G>A	ENST00000378122.3	+	0	545				PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_De_novo_Start_OutOfFrame|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTTGCCGCGATGTTCTCTC	0.393000													11	4					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87678058	87678058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:87678058C>T	ENST00000284262.2	+	2	819	c.577C>T	c.(577-579)Cgc>Tgc	p.R193C		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	193					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		GGCCGTGTCCCGCGGGGGCTT	0.687000													32	62					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199156	118199156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:118199156G>A	ENST00000425217.1	-	4	613	c.559C>T	c.(559-561)Ccc>Tcc	p.P187S	KSR2_ENST00000339824.5_Missense_Mutation_p.P216S	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	216	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGGCCCCGGGAGTGGGGCTG	0.706000													12	22					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25789932	25789932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25789932C>T	ENST00000399878.3	-	13	2253	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	SEL1L3_ENST00000264868.5_Missense_Mutation_p.E676K|SEL1L3_ENST00000502949.1_Missense_Mutation_p.E558K	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	711						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						ATTGCTGCTTCGGGATTCTTG	0.463000													40	115					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184104544	184104544	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184104544G>A	ENST00000204604.1	+	16	2442		c.e16+1		CHRD_ENST00000348986.3_Splice_Site|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000545352.1_Intron|CHRD_ENST00000450923.1_Splice_Site	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin						BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CACCTGCCAGGTAGGAGGTCC	0.657000													4	10					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39358846	39358846	+	Missense_Mutation	SNP	G	G	A	rs121434355		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39358846G>A	ENST00000280481.7	+	6	6136	c.5920G>A	c.(5920-5922)Gag>Aag	p.E1974K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1974	Calx-beta 2.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTACGAGGAGGAGGAAACCTT	0.498000													35	59					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185698093	185698093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:185698093G>A	ENST00000515030.1	-	6	847	c.522C>T	c.(520-522)atC>atT	p.I174I	ACSL1_ENST00000281455.2_Silent_p.I174I|ACSL1_ENST00000504900.1_Silent_p.I174I|ACSL1_ENST00000504342.1_Silent_p.I174I|ACSL1_ENST00000507295.1_Silent_p.I140I|ACSL1_ENST00000437665.3_Silent_p.I3I|ACSL1_ENST00000513317.1_Silent_p.I174I|ACSL1_ENST00000454703.2_Silent_p.I3I			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	174					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AAAGTGGAACGATCACCATCG	0.388000													4	46					0	0	1	0	0
TBX6	6911	broad.mit.edu	37	16	30097955	30097955	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30097955T>C	ENST00000395224.2	-	8	1034	c.975A>G	c.(973-975)gaA>gaG	p.E325E	TBX6_ENST00000279386.2_Silent_p.E325E	NM_004608.3	NP_004599.2	O95947	TBX6_HUMAN	T-box 6	325					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						CTGGGGCCTGTTCTGGATCTG	0.662000													3	11					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6239815	6239815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6239815C>T	ENST00000400104.3	-	9	809	c.609G>A	c.(607-609)agG>agA	p.R203R	L3MBTL4_ENST00000535782.1_Silent_p.R16R|L3MBTL4_ENST00000400105.2_Silent_p.R203R|L3MBTL4_ENST00000317931.7_Silent_p.R203R|L3MBTL4_ENST00000284898.6_Silent_p.R203R			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	203					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				AAGGGTTCTTCCTGTCCACGG	0.463000													24	68					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933907	44933907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44933907C>T	ENST00000291187.4	-	6	1353	c.1031G>A	c.(1030-1032)aGa>aAa	p.R344K	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Missense_Mutation_p.R350K	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GACATCACATCTATAGGGCAT	0.507000													12	124					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28711559	28711559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28711559C>T	ENST00000257197.3	-	15	2746	c.2485G>A	c.(2485-2487)Gaa>Aaa	p.E829K	RP11-408H20.2_ENST00000581836.1_RNA|RP11-408H20.3_ENST00000582307.1_RNA|DSC1_ENST00000257198.5_Missense_Mutation_p.E829K	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	829					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GAACTTACTTCGCCAAGCCGA	0.453000													24	96					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99308381	99308381	+	Missense_Mutation	SNP	C	C	T	rs147031398		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99308381C>T	ENST00000336374.2	-	10	1002	c.1000G>A	c.(1000-1002)Gaa>Aaa	p.E334K		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	334					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					GTATCAATTTCCTTCTGCACT	0.453000													22	69					0	0	1	0	0
TRBV5-7	28608	broad.mit.edu	37	7	142111471	142111471	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142111471G>A	ENST00000390378.1	-	0	264																											CTATAGTTAGGGAACTGGTGA	0.517000													52	88					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57872937	57872937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57872937C>T	ENST00000393797.2	-	5	658	c.466G>A	c.(466-468)Gag>Aag	p.E156K	ARHGAP9_ENST00000550288.1_Missense_Mutation_p.E164K|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.E85K|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.E85K|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.E85K			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	85					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			ATGGATTCCTCTATCATATAG	0.557000													10	118					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626490	49626490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49626490G>A	ENST00000371571.4	-	2	671	c.386C>T	c.(385-387)aCc>aTc	p.T129I	KCNG1_ENST00000396017.3_Missense_Mutation_p.T129I|RP5-955M13.4_ENST00000424566.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	129						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GCGCAGGAAGGTCAGGATAGT	0.632000													23	61					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79399106	79399106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79399106G>A	ENST00000264895.6	+	55	8429	c.7989G>A	c.(7987-7989)gcG>gcA	p.A2663A		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2658	Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCACCCAGGCGAAGGTCATTA	0.458000													5	23					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117221501	117221501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:117221501G>A	ENST00000355044.3	+	22	3499	c.3373G>A	c.(3373-3375)Gat>Aat	p.D1125N	ATRNL1_ENST00000303745.7_Intron|ATRNL1_ENST00000423111.2_Missense_Mutation_p.D176N	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1125						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ACAGGAAGATGATCGCCACCA	0.323000													11	72					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43918417	43918417	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43918417G>A	ENST00000336086.6	-	4	2752	c.516C>T	c.(514-516)ctC>ctT	p.L172L	URGCP_ENST00000223341.7_Silent_p.L172L|URGCP_ENST00000443736.1_Silent_p.L172L|RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000453200.1_Silent_p.L215L|URGCP_ENST00000447717.3_Silent_p.L172L|URGCP_ENST00000402306.3_Silent_p.L206L|URGCP_ENST00000497914.1_5'UTR			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	215					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CAGGCAACACGAGTGGGAGTG	0.562000													11	29					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241991199	241991199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241991199G>A	ENST00000310397.8	+	13	1774	c.1774G>A	c.(1774-1776)Ggg>Agg	p.G592R	SNED1_ENST00000405547.3_Missense_Mutation_p.G592R|SNED1_ENST00000342631.6_Missense_Mutation_p.G592R|SNED1_ENST00000401884.1_Missense_Mutation_p.G592R|AC005237.4_ENST00000458377.1_RNA|SNED1_ENST00000469006.1_3'UTR	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	592	EGF-like 8.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		CTGCCGGAACGGGGGCACGTG	0.697000													3	5					0	0	1	0	0
SH2D3A	10045	broad.mit.edu	37	19	6760821	6760821	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6760821C>T	ENST00000245908.6	-	3	516	c.247G>A	c.(247-249)Gag>Aag	p.E83K	SH2D3A_ENST00000437152.3_Intron|SH2D3A_ENST00000599563.1_5'UTR	NM_005490.2	NP_005481.2	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	83	SH2.				JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|urinary_tract(1)	24						GGGAATTGCTCATCCTCCAGT	0.637000													20	54					0	0	1	0	0
SOX7	83595	broad.mit.edu	37	8	10583582	10583582	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10583582G>A	ENST00000304501.1	-	2	911	c.833C>T	c.(832-834)cCc>cTc	p.P278L	SOX7_ENST00000554914.1_Missense_Mutation_p.P330L|SOX7_ENST00000553390.1_Missense_Mutation_p.P330L	NM_031439.2	NP_113627.1	Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	278	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		AGGAGATGGGGGACAGCCGGG	0.677000													16	27					0	0	1	0	0
TNPO3	23534	broad.mit.edu	37	7	128615975	128615975	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128615975G>T	ENST00000393245.1	-	17	2551	c.2178C>A	c.(2176-2178)taC>taA	p.Y726*	TNPO3_ENST00000471234.1_Nonsense_Mutation_p.Y628*|TNPO3_ENST00000471166.1_Nonsense_Mutation_p.Y726*|TNPO3_ENST00000265388.5_Nonsense_Mutation_p.Y692*|TNPO3_ENST00000482320.1_Nonsense_Mutation_p.Y626*	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	692					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						GATGTACGTGGTACACATTCA	0.458000													19	49					1.28384e-07	1.28755e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179407830	179407830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179407830C>T	ENST00000589042.1	-	347	97094	c.96870G>A	c.(96868-96870)gaG>gaA	p.E32290E	TTN_ENST00000342992.6_Silent_p.E29722E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Silent_p.E23225E|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.E23417E|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.E23350E|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Silent_p.E30649E|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30649	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTGACAGTCTCTCTTGGTT	0.368000													95	207					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146720077	146720077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:146720077C>T	ENST00000392299.2	+	8	2372	c.1902C>T	c.(1900-1902)atC>atT	p.I634I	GRM1_ENST00000507907.1_Silent_p.I634I|GRM1_ENST00000282753.1_Silent_p.I634I|GRM1_ENST00000355289.4_Silent_p.I634I|GRM1_ENST00000361719.2_Silent_p.I634I|GRM1_ENST00000492807.2_Silent_p.I634I			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	634					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GCTACATCATCCTAGCTGGCA	0.522000													81	97					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5540286	5540286	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5540286G>A	ENST00000382368.3	-	3	1737	c.1614C>T	c.(1612-1614)ctC>ctT	p.L538L	FBXL18_ENST00000453700.3_Silent_p.L538L	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	538									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GCAGCTGTGCGAGCGTCAGGT	0.687000													11	19					0	0	1	0	0
AP3M2	10947	broad.mit.edu	37	8	42015560	42015560	+	Silent	SNP	C	C	T	rs113481990		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42015560C>T	ENST00000518421.1	+	4	666	c.375C>T	c.(373-375)acC>acT	p.T125T	AP3M2_ENST00000517922.1_Silent_p.T125T|AP3M2_ENST00000396926.3_Silent_p.T125T|AP3M2_ENST00000174653.3_Silent_p.T125T|AP3M2_ENST00000520685.1_Intron	NM_001134296.1	NP_001127768.1	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	125					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus				endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|stomach(1)	17	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			CATTGGCTACCGAGTCGAACA	0.428000													15	114					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78758726	78758726	+	Missense_Mutation	SNP	G	G	A	rs143720317		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78758726G>A	ENST00000258886.8	+	5	673	c.524G>A	c.(523-525)cGa>cAa	p.R175Q	IREB2_ENST00000560440.1_Missense_Mutation_p.R175Q|IREB2_ENST00000559427.1_3'UTR	NM_004136.2	NP_004127.1	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	175							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		ACTACCTGCCGAGGATCTTGT	0.498000													46	60					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47571021	47571021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47571021G>A	ENST00000253048.5	-	15	2541	c.2504C>T	c.(2503-2505)tCa>tTa	p.S835L	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	835							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		CTCCCCAACTGAAGCCGGGGG	0.652000													3	13					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2040160	2040160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2040160G>A	ENST00000250896.3	-	13	1371	c.1127C>T	c.(1126-1128)aCc>aTc	p.T376I	MKNK2_ENST00000541165.1_Missense_Mutation_p.T245I|MKNK2_ENST00000309340.7_Missense_Mutation_p.T376I|MKNK2_ENST00000591601.1_Missense_Mutation_p.T376I|MKNK2_ENST00000591142.1_Missense_Mutation_p.T120I|MKNK2_ENST00000588014.1_Missense_Mutation_p.T120I|MKNK2_ENST00000591588.1_Missense_Mutation_p.T120I	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	376	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTGGGCAAGGTGTTCTCCGG	0.677000													3	8					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64427844	64427844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64427844C>T	ENST00000265459.6	-	11	2810	c.2349G>A	c.(2347-2349)ctG>ctA	p.L783L	NRXN2_ENST00000377559.3_Silent_p.L752L|NRXN2_ENST00000409571.1_Silent_p.L776L|NRXN2_ENST00000377551.1_Silent_p.L783L	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	783	Laminin G-like 4.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CATCCAGCTCCAGGCGTAGGG	0.617000													9	72					0	0	1	0	0
C10orf62	414157	broad.mit.edu	37	10	99349560	99349560	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99349560G>A	ENST00000370640.3	+	0	111				HOGA1_ENST00000370647.4_Intron|HOGA1_ENST00000370646.4_Intron|PI4K2A_ENST00000555577.1_Intron|PI4K2A_ENST00000370649.3_Intron	NM_001009997.2	NP_001009997.2	Q5T681	CJ062_HUMAN	chromosome 10 open reading frame 62								protein binding			endometrium(2)|kidney(1)|lung(1)	4		Colorectal(252;0.162)		Epithelial(162;9.58e-11)|all cancers(201;8.62e-09)		CTGCCTGCCTGGTGTAGGGTC	0.592000													6	41					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20801753	20801753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20801753C>T	ENST00000359062.3	+	13	2737	c.2697C>T	c.(2695-2697)ttC>ttT	p.F899F	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	899	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ATTTCCGTTTCCTTGTCATTG	0.403000													24	102					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169362547	169362547	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169362547G>A	ENST00000511577.1	-	10	1482	c.1235C>T	c.(1234-1236)tCt>tTt	p.S412F	DDX60L_ENST00000505890.1_Missense_Mutation_p.S412F|DDX60L_ENST00000260184.7_Missense_Mutation_p.S412F			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	412							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CAGAGGAAAAGACTTTCCAAC	0.373000													20	95					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55012584	55012584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:55012584C>T	ENST00000371336.3	+	2	602	c.401C>T	c.(400-402)cCc>cTc	p.P134L	CASS4_ENST00000360314.3_Missense_Mutation_p.P134L|CASS4_ENST00000434344.1_Missense_Mutation_p.P134L	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	134					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						TATGAATTCCCCGACCCTCCC	0.572000													53	115					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29275126	29275126	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29275126C>T	ENST00000377160.2	+	1	724	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						TTCGCATCTTCTCTACAGTGC	0.468000													51	160					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919520	4919520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4919520C>T	ENST00000433855.1	+	1	1179	c.313C>T	c.(313-315)Cgc>Tgc	p.R105C	KCNA6_ENST00000280684.3_Missense_Mutation_p.R105C	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	105						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GTCTGGGGGCCGCCTGCGGAG	0.657000										HNSCC(72;0.22)			45	68					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27465590	27465590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27465590C>T	ENST00000264705.4	+	41	6487	c.6325C>T	c.(6325-6327)Ctg>Ttg	p.L2109L	CAD_ENST00000403525.1_Silent_p.L2046L	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	2109	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	ACCTCCCAGCCTGCGCATGCC	0.652000													6	72					0	0	1	0	0
BZW2	28969	broad.mit.edu	37	7	16714053	16714053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:16714053C>T	ENST00000433922.2	+	3	253	c.75C>T	c.(73-75)ttC>ttT	p.F25F	BZW2_ENST00000452975.2_Silent_p.F25F|BZW2_ENST00000258761.3_Silent_p.F25F|BZW2_ENST00000405202.1_5'UTR	NM_001159767.1	NP_001153239.1	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	25					cell differentiation|nervous system development|RNA metabolic process		protein binding	p.F25F(1)		cervix(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	15	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		AAGAGAAATTCGAACCCACAG	0.333000													37	102					0	0	1	0	0
SIM2	6493	broad.mit.edu	37	21	38098611	38098611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38098611G>A	ENST00000290399.6	+	6	1348	c.735G>A	c.(733-735)ctG>ctA	p.L245L	SIM2_ENST00000430056.3_Silent_p.L245L	NM_005069.3	NP_005060.1	Q14190	SIM2_HUMAN	single-minded family bHLH transcription factor 2	245	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(2)	16						TGATATTCCTGGATTCCAGGT	0.562000													9	21					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117310547	117310547	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117310547C>T	ENST00000321322.6	-	22	4149	c.4148G>A	c.(4147-4149)tGg>tAg	p.W1383*	DSCAML1_ENST00000527706.1_Nonsense_Mutation_p.W1113*	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1323	Fibronectin type-III 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTCCTTGGTCCACTTCACAGC	0.567000													45	186					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3328402	3328402	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3328402C>T	ENST00000378398.3	+	10	1726	c.1644C>T	c.(1642-1644)ctC>ctT	p.L548L	PRDM16_ENST00000378391.2_Silent_p.L547L|PRDM16_ENST00000270722.5_Silent_p.L547L|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Silent_p.L547L|PRDM16_ENST00000441472.2_Silent_p.L547L|PRDM16_ENST00000514189.1_Silent_p.L548L|PRDM16_ENST00000511072.1_Silent_p.L548L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	547	Pro-rich.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ACGCCAAGCTCCCCAGTCCCC	0.682000			T	EVI1	"""MDS, AML"""								47	105					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196718101	196718101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196718101G>A	ENST00000312428.6	-	46	8847	c.8747C>T	c.(8746-8748)gCt>gTt	p.A2916V		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2916					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCGAGGTAAGCAACCACTCC	0.507000													6	59					0	0	1	0	0
WNT16	51384	broad.mit.edu	37	7	120979048	120979048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120979048G>A	ENST00000222462.2	+	4	1037	c.747G>A	c.(745-747)ttG>ttA	p.L249L	WNT16_ENST00000361301.2_Silent_p.L239L	NM_057168.1	NP_476509.1	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family, member 16	249					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)	18	all_neural(327;0.117)					GCCATTTGTTGAAGGATAAAT	0.413000													22	44					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102270432	102270432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:102270432G>A	ENST00000370103.4	-	6	952	c.739C>T	c.(739-741)Cgt>Tgt	p.R247C	OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000338858.5_Missense_Mutation_p.R267C|OLFM3_ENST00000536598.1_3'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	267	Olfactomedin-like.					extracellular region		p.R267S(1)|p.R247S(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TTGTATTCACGAACAATTTTA	0.378000													30	68					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8619417	8619417	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8619417C>T	ENST00000338257.8	-	4	537	c.270G>A	c.(268-270)acG>acA	p.T90T		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	90	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						ACATGTTGTCCGTGAGGGCGT	0.622000													35	123					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940519	113940519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113940519G>A	ENST00000245796.6	+	2	681	c.486G>A	c.(484-486)caG>caA	p.Q162Q	PSD4_ENST00000441564.2_Silent_p.Q162Q|PSD4_ENST00000465917.1_3'UTR	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	162					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCATCCTGCAGGCCCAGATGT	0.617000													6	84					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32187941	32187941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32187941G>A	ENST00000375023.3	-	7	1418	c.1280C>T	c.(1279-1281)cCc>cTc	p.P427L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	427	EGF-like 10.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GTGGCAGGTGGGCCCCGAATA	0.612000													15	39					0	0	1	0	0
TRAV30	28652	broad.mit.edu	37	14	22636798	22636798	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22636798C>T	ENST00000557168.1	+	0	251																											ATATCTGCTTCATTTAATGAA	0.468000													22	47					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45949718	45949718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45949718C>T	ENST00000323084.4	-	5	818	c.753G>A	c.(751-753)ggG>ggA	p.G251G	TSPEAR_ENST00000397916.1_Silent_p.G183G	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	251					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CTTCTGGCTTCCCCGTGAGAG	0.642000													30	54					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87457444	87457444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:87457444G>A	ENST00000268616.4	-	4	618	c.401C>T	c.(400-402)tCc>tTc	p.S134F		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	134					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CACTTCAGAGGAAGATTTGGT	0.368000													31	61					0	0	1	0	0
FBXO28	23219	broad.mit.edu	37	1	224340893	224340893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:224340893C>T	ENST00000366862.5	+	4	609	c.566C>T	c.(565-567)gCc>gTc	p.A189V	FBXO28_ENST00000424254.2_Intron	NM_015176.3	NP_055991.1	Q9NVF7	FBX28_HUMAN	F-box protein 28	189										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(2)|skin(1)	10	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		TCTACCAGAGCCCCTCAACGA	0.323000													22	81					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32636195	32636195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:32636195C>T	ENST00000335185.5	-	16	1712	c.1669G>A	c.(1669-1671)Gga>Aga	p.G557R		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	557										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					ACATCTAATCCTCTGGTTCTT	0.294000													11	30					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96952164	96952164	+	Silent	SNP	G	G	A	rs143175658		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96952164G>A	ENST00000323853.5	-	29	3965	c.3888C>T	c.(3886-3888)ccC>ccT	p.P1296P	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1296						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CGGTTGGAGGGGGGTACTTCT	0.502000													32	101					0	0	1	0	0
ZNF736	728927	broad.mit.edu	37	7	63809132	63809132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:63809132C>T	ENST00000355095.4	+	5	1213	c.891C>T	c.(889-891)ttC>ttT	p.F297F	ZNF736_ENST00000423484.1_Silent_p.F297F	NM_001170905.1	NP_001164376.1	B4DX44	ZN736_HUMAN	zinc finger protein 736	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|stomach(1)|urinary_tract(1)	9						ATAGGTGGTTCTCAGACCTTG	0.378000													7	19					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94574247	94574247	+	Nonsense_Mutation	SNP	G	G	A	rs61748531		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94574247G>A	ENST00000370225.3	-	4	414	c.328C>T	c.(328-330)Caa>Taa	p.Q110*	ABCA4_ENST00000535735.1_Nonsense_Mutation_p.Q110*	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	110					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AGGAGTTCTTGAAAATCTCGA	0.418000													24	46					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124740999	124740999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124740999C>T	ENST00000397801.1	+	7	1315	c.1123C>T	c.(1123-1125)Cca>Tca	p.P375S	ROBO3_ENST00000538940.1_Missense_Mutation_p.P353S	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	375	Ig-like C2-type 4.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		AGGAAACCCCCCACCTGCCAT	0.632000													11	53					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10404786	10404786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10404786C>T	ENST00000226207.5	-	27	3473	c.3379G>A	c.(3379-3381)Gag>Aag	p.E1127K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1127						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CGCTCTGCCTCGATTTCCTCC	0.542000													30	32					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74357718	74357718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74357718G>A	ENST00000226355.3	+	8	1066	c.973G>A	c.(973-975)Gat>Aat	p.D325N		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	325	Albumin 2.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TAGACCAAAGGATTTATCTCT	0.378000													36	92					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207751310	207751310	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207751310C>T	ENST00000367049.4	+	29	4698	c.4698C>T	c.(4696-4698)acC>acT	p.T1566T	CR1_ENST00000367052.1_Silent_p.T1116T|CR1_ENST00000367051.1_Silent_p.T1116T|CR1_ENST00000400960.2_Silent_p.T1116T|RP11-78B10.2_ENST00000596003.1_RNA|RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367053.1_Silent_p.T1116T	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1116	Sushi 24.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TATACTGCACCAGCAATGACG	0.493000													53	119					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74429805	74429805	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74429805G>A	ENST00000376332.3	-	2	651	c.155C>T	c.(154-156)cCa>cTa	p.P52L	CHRDL2_ENST00000263671.5_Missense_Mutation_p.P52L|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	52	VWFC 1.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					CAGGCCTTGTGGCTCCAAGTA	0.577000													8	25					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216896	21216896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21216896C>T	ENST00000380216.1	-	1	414	c.409G>A	c.(409-411)Gag>Aag	p.E137K		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	137					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		ATGGAGTCCTCATTCATCAGG	0.468000													31	294					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45945563	45945563	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45945563A>G	ENST00000323084.4	-	8	1374	c.1309T>C	c.(1309-1311)Ttc>Ctc	p.F437L	TSPEAR_ENST00000397916.1_Missense_Mutation_p.F369L|C21orf90_ENST00000465978.1_Intron	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	437					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						ACCGCCAGGAAGTGCTCCCCA	0.602000													47	119					0	0	1	0	0
PMEPA1	56937	broad.mit.edu	37	20	56234689	56234689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56234689G>A	ENST00000341744.3	-	2	493	c.174C>T	c.(172-174)atC>atT	p.I58I	PMEPA1_ENST00000265626.4_Silent_p.I8I|PMEPA1_ENST00000395816.3_Silent_p.I8I|PMEPA1_ENST00000395814.1_Silent_p.I8I|PMEPA1_ENST00000472841.1_5'UTR|PMEPA1_ENST00000347215.4_Silent_p.I23I	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	58					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GCAGGCACGTGatcaccacca	0.577000													3	12					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477323	88477323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:88477323G>A	ENST00000267549.3	+	2	690	c.132G>A	c.(130-132)aaG>aaA	p.K44K	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	44					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TGCAAGCAAAGAAGGAAAGTG	0.368000													11	123					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56388240	56388240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:56388240G>A	ENST00000423270.1	-	9	1685	c.1686C>T	c.(1684-1686)ccC>ccT	p.P562P	RFX7_ENST00000317318.6_Silent_p.P562P|RFX7_ENST00000422057.1_Silent_p.P465P|RFX7_ENST00000559447.2_Silent_p.P465P	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	465					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TAGGTGTCTGGGGAGCTTTAG	0.473000													6	16					0	0	1	0	0
SULT1B1	27284	broad.mit.edu	37	4	70620411	70620411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70620411G>A	ENST00000310613.2	-	3	551	c.254C>T	c.(253-255)aCt>aTt	p.T85I		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1	85					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol				breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						TCCAGGGAGAGTCATTTCCAA	0.303000													46	133					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	108518795	108518795	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:108518795G>A	ENST00000375915.2	-	1	288	c.150C>T	c.(148-150)gtC>gtT	p.V50V		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	50						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CAGAGAGCAGGACTGTGAAAA	0.597000													48	135					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192190	211192190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:211192190C>T	ENST00000271751.4	-	6	994	c.967G>A	c.(967-969)Ggt>Agt	p.G323S	KCNH1_ENST00000367007.4_Intron			O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	323					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCTGGATCACCCATAAAGGCA	0.468000													38	129					0	0	1	0	0
SPATA9	83890	broad.mit.edu	37	5	94994441	94994441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94994441C>T	ENST00000274432.8	-	5	792	c.651G>A	c.(649-651)ccG>ccA	p.P217P	SPATA9_ENST00000477047.2_Intron|RFESD_ENST00000508206.1_Intron	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	217					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		CTGGCTTCTCCGGCAATGACC	0.403000													29	51					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53232924	53232924	+	Silent	SNP	C	C	T	rs140251181		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53232924C>T	ENST00000359499.4	-	9	1217	c.1206G>A	c.(1204-1206)tcG>tcA	p.S402S	KRT78_ENST00000304620.4_Silent_p.S512S			Q8N1N4	K2C78_HUMAN	keratin 78	512	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						TCTTCAGACTCGACTCAACTG	0.582000													9	16					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126219690	126219690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126219690C>T	ENST00000290868.2	-	11	1046	c.993G>A	c.(991-993)acG>acA	p.T331T	UROC1_ENST00000383579.3_Silent_p.T391T	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	331					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		ACTCCCCCGTCGTGTCCAATT	0.647000													12	47					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103629630	103629630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103629630G>A	ENST00000424685.2	-	1	333	c.174C>T	c.(172-174)tcC>tcT	p.S58S	RELN_ENST00000343529.5_Silent_p.S58S|RELN_ENST00000428762.1_Silent_p.S58S			P78509	RELN_HUMAN	reelin	58	Reelin.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAATATGCAGGGAAATGAGCA	0.652000													15	60					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3188392	3188392	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3188392C>T	ENST00000355072.5	+	38	5080	c.4935C>T	c.(4933-4935)tcC>tcT	p.S1645S		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1645					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCCCTTCCTCCCTCCGTCCGG	0.468000													69	174					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141597566	141597566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141597566G>A	ENST00000389484.3	-	31	6174	c.5203C>T	c.(5203-5205)Cca>Tca	p.P1735S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1735					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTACCAACTGGCTCCTTCTGA	0.328000										TSP Lung(27;0.18)			6	28					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169374	90169374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:90169374C>T	ENST00000333209.3	-	2	2406	c.1888G>A	c.(1888-1890)Gcc>Acc	p.A630T		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	630										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		CGTGGGCTGGCTTTGACGGAG	0.582000													40	83					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76712688	76712688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76712688G>A	ENST00000369950.3	-	12	1427	c.1238C>T	c.(1237-1239)cCt>cTt	p.P413L	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	413					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTCAACAGGAGGAAGTTCTGG	0.423000													11	38					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57970781	57970781	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57970781G>A	ENST00000302592.6	-	1	872	c.873C>T	c.(871-873)ttC>ttT	p.F291F		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				TCACCACAGTGAATAGGACAG	0.453000													60	123					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102376371	102376371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:102376371C>T	ENST00000369138.1	+	13	2439	c.1949C>T	c.(1948-1950)tCg>tTg	p.S650L	GRIK2_ENST00000369137.3_Missense_Mutation_p.S574L|GRIK2_ENST00000413795.1_Missense_Mutation_p.S650L|GRIK2_ENST00000318991.6_Missense_Mutation_p.S650L|GRIK2_ENST00000369134.4_Missense_Mutation_p.S601L|GRIK2_ENST00000421544.1_Missense_Mutation_p.S650L	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	650					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	ATCATTTCTTCGTATACTGCT	0.448000													29	31					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105361807	105361807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105361807G>A	ENST00000369774.4	-	15	3444	c.3168C>T	c.(3166-3168)tcC>tcT	p.S1056S	SH3PXD2A_ENST00000540321.1_Silent_p.S923S|SH3PXD2A_ENST00000538130.1_Silent_p.S891S|SH3PXD2A_ENST00000427662.2_Intron|SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000355946.2_Silent_p.S1028S			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	1056					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GGCGCACAGGGGACACGGGTA	0.627000													52	129					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47942791	47942791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47942791C>T	ENST00000402813.3	-	9	1002	c.860G>A	c.(859-861)cGa>cAa	p.R287Q	CNGA1_ENST00000358519.4_Missense_Mutation_p.R218Q|CNGA1_ENST00000514170.1_Missense_Mutation_p.R218Q|CNGA1_ENST00000420489.2_Missense_Mutation_p.R218Q|CNGA1_ENST00000544810.1_Missense_Mutation_p.R218Q			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	218					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity	p.R218Q(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						TGTCCTTGTTCGTACAAACAT	0.294000													22	57					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423464	56423464	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56423464G>A	ENST00000588751.1	-	5	1743	c.1719C>T	c.(1717-1719)gtC>gtT	p.V573V	NLRP13_ENST00000342929.3_Silent_p.V573V			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	573							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TGTCAAGCAAGACGTGTTGCA	0.418000													40	109					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66942707	66942707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:66942707G>A	ENST00000374690.3	+	7	3012	c.2488G>A	c.(2488-2490)Gaa>Aaa	p.E830K	AR_ENST00000396043.2_Missense_Mutation_p.E298K|AR_ENST00000396044.3_Intron	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	829	Interaction with MYST2.|Ligand-binding.		L -> P (in prostate cancer).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	ATTCTTTGATGAACTTCGAAT	0.443000									Androgen Insensitivity Syndrome				4	16					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30551997	30551997	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30551997C>T	ENST00000326195.8	+	13	1243	c.1131C>T	c.(1129-1131)gtC>gtT	p.V377V	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Silent_p.V339V	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	377	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						CACCAGCAGTCCAGGCTGTTC	0.552000													6	65					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34004285	34004285	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34004285C>T	ENST00000374181.3	-	8	1771	c.1602G>A	c.(1600-1602)aaG>aaA	p.K534K	GRM4_ENST00000535756.1_Silent_p.K401K|GRM4_ENST00000374177.3_Silent_p.K418K|GRM4_ENST00000538487.1_Silent_p.K534K|GRM4_ENST00000545715.1_Silent_p.K226K|GRM4_ENST00000455714.2_Silent_p.K394K|GRM4_ENST00000544773.1_Silent_p.K365K	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	534					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	AAGGCATGCCCTTCACTGTCT	0.642000													18	47					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10408708	10408708	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10408708G>A	ENST00000226207.5	-	20	2389	c.2295C>T	c.(2293-2295)acC>acT	p.T765T	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	765	Actin-binding (By similarity).|Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						ATATTACCTTGGTGTGACCAA	0.408000													44	81					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71096192	71096192	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71096192G>A	ENST00000393567.2	-	17	2406	c.2256C>T	c.(2254-2256)ccC>ccT	p.P752P	HYDIN_ENST00000538248.1_Silent_p.P779P|HYDIN_ENST00000321489.5_Silent_p.P752P|HYDIN_ENST00000448691.1_Silent_p.P752P|HYDIN_ENST00000541601.1_Silent_p.P769P|HYDIN_ENST00000448089.2_Silent_p.P752P	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	752										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TGACCCCGCTGGGGGTGGGGC	0.552000													3	7					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111156379	111156379	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111156379G>A	ENST00000280325.4	+	4	458	c.309_splice	c.e4-1	p.R104_splice		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	104										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		TCTCCTCAGAGGGACTCATGG	0.587000													9	69					0	0	1	0	0
DPAGT1	1798	broad.mit.edu	37	11	118967876	118967876	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118967876G>A	ENST00000409993.2	-	10	2688	c.1137C>T	c.(1135-1137)ctC>ctT	p.L379L	DPAGT1_ENST00000432443.2_Silent_p.L272L|DPAGT1_ENST00000354202.4_Silent_p.L379L			Q9H3H5	GPT_HUMAN	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	379					dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	17	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		GGAGCAATGTGAGGTTTCTCT	0.473000													65	137					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41012789	41012789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41012789C>T	ENST00000399564.4	-	30	3481	c.3031G>A	c.(3031-3033)Gaa>Aaa	p.E1011K	MROH2B_ENST00000506092.2_Missense_Mutation_p.E566K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TCCAGCATTTCCTCTAGGAAC	0.458000													25	81					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	57005376	57005376	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57005376G>A	ENST00000179765.5	-	8	1760	c.1561C>T	c.(1561-1563)Cgt>Tgt	p.R521C	BAZ2A_ENST00000551812.1_Missense_Mutation_p.R553C|BAZ2A_ENST00000379441.3_Missense_Mutation_p.R523C|BAZ2A_ENST00000549884.1_Missense_Mutation_p.R551C			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	553					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						AGGGGAAGACGAACTTCTTCT	0.418000													12	29					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655781	19655781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19655781C>T	ENST00000586018.1	+	8	2547	c.2445C>T	c.(2443-2445)gtC>gtT	p.V815V	CILP2_ENST00000291495.4_Silent_p.V809V			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	809						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						CCGCCCTGGTCACCGCCACCC	0.746000													8	15					0	0	1	0	0
SPARCL1	8404	broad.mit.edu	37	4	88415108	88415108	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88415108A>T	ENST00000418378.1	-	5	1415	c.844T>A	c.(844-846)Tcg>Acg	p.S282T	SPARCL1_ENST00000282470.6_Missense_Mutation_p.S282T|SPARCL1_ENST00000503414.1_Missense_Mutation_p.S157T	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	282					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TTGACGTTCGATGCATTTTCC	0.413000													125	316					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585475	82585475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82585475C>T	ENST00000423517.2	-	5	5131	c.4794G>A	c.(4792-4794)aaG>aaA	p.K1598K	PCLO_ENST00000333891.8_Silent_p.K1598K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1529					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGCCTTTTCCCTTTGTTTCTT	0.433000													52	173					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76735651	76735651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76735651C>T	ENST00000287239.4	+	8	2045	c.1556C>T	c.(1555-1557)cCc>cTc	p.P519L	KAT6B_ENST00000372714.1_Intron|KAT6B_ENST00000372725.1_Intron|KAT6B_ENST00000372724.1_Intron|KAT6B_ENST00000372711.1_Intron	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	519	Negatively regulates HAT activity.|Ser-rich.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										TCTCCCTCTCCCCAGAGTTCT	0.547000													35	86					0	0	1	0	0
CCKBR	887	broad.mit.edu	37	11	6290997	6290997	+	Missense_Mutation	SNP	C	C	T	rs148924129		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6290997C>T	ENST00000525462.1	+	2	253	c.250C>T	c.(250-252)Cgc>Tgc	p.R84C	CCKBR_ENST00000334619.2_Missense_Mutation_p.R84C|CCKBR_ENST00000531712.1_3'UTR|CCKBR_ENST00000525014.1_Missense_Mutation_p.R84C|CCKBR_ENST00000532715.1_Intron			P32239	GASR_HUMAN	cholecystokinin B receptor	84					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	ACTGAGCCGCCGCCTGAGGAC	0.552000													30	84					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77671544	77671544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:77671544C>T	ENST00000461745.1	+	23	4621	c.3721C>T	c.(3721-3723)Cct>Tct	p.P1241S	ROBO2_ENST00000487694.3_Missense_Mutation_p.P1257S|ROBO2_ENST00000332191.8_Missense_Mutation_p.P1241S	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1241					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GGACCAGACTCCTGGATCCAG	0.448000													19	43					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105174832	105174832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105174832C>T	ENST00000369797.3	+	12	1536	c.1442C>T	c.(1441-1443)cCt>cTt	p.P481L		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	481	S1 motif 5.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GGCCTGGTACCTCCCATGCAC	0.537000													22	44					0	0	1	0	0
LOXL3	84695	broad.mit.edu	37	2	74763927	74763927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74763927C>T	ENST00000264094.3	-	5	892	c.821G>A	c.(820-822)gGg>gAg	p.G274E	LOXL3_ENST00000393937.2_Intron|LOXL3_ENST00000409549.1_Missense_Mutation_p.G274E|LOXL3_ENST00000409249.1_Missense_Mutation_p.G274E|LOXL3_ENST00000409986.1_Intron	NM_032603.2	NP_115992.1	P58215	LOXL3_HUMAN	lysyl oxidase-like 3	274	SRCR 2.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity			endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30						TGCAGGGCCCCCCCCAGGGCA	0.642000													44	95					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519885	69519885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69519885G>A	ENST00000338206.5	-	5	1192	c.1183C>T	c.(1183-1185)Ccc>Tcc	p.P395S		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	395					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										GCAAACAAGGGAATGCCCACC	0.463000													27	254					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43771241	43771241	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43771241G>A	ENST00000389420.3	-	32	4921	c.4922C>T	c.(4921-4923)cCt>cTt	p.P1641L		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1641	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGAGAGGAAGGCACCACAGG	0.408000													5	35					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61498026	61498026	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61498026C>T	ENST00000424789.2	+	25	4687	c.4683C>T	c.(4681-4683)ccC>ccT	p.P1561P	TANC2_ENST00000389520.4_Silent_p.P1571P|RP11-269G24.3_ENST00000583552.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1561							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CTGGTTCACCCGTGCGCTATC	0.582000													10	29					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45561771	45561771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45561771C>T	ENST00000415258.1	+	18	2416	c.2275C>T	c.(2275-2277)Ctc>Ttc	p.L759F	LARS2_ENST00000414984.1_Missense_Mutation_p.L716F|LARS2_ENST00000467936.1_3'UTR|LARS2_ENST00000265537.3_Missense_Mutation_p.L759F			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	759					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	GCTGATGGGACTCAGCAATGC	0.493000													13	98					0	0	1	0	0
NTN5	126147	broad.mit.edu	37	19	49167855	49167855	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49167855G>A	ENST00000270235.4	-	3	896	c.801C>T	c.(799-801)ttC>ttT	p.F267F	SEC1P_ENST00000430145.2_RNA	NM_145807.1	NP_665806.1	Q8WTR8	NET5_HUMAN	netrin 5	267	Laminin EGF-like 2.					extracellular region		p.F267L(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	10						CCCTGCGGCTGAAGATAGGCT	0.682000													9	39					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332551	100332551	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:100332551G>A	ENST00000341853.1	-	0	1640				AC090825.1_ENST00000408584.1_RNA	NR_003260.1																						GCCGTCGGAGGGACCTCAGCG	0.582000													14	129					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153430313	153430313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153430313C>T	ENST00000368723.3	-	3	385	c.275G>A	c.(274-276)gGa>gAa	p.G92E	S100A7_ENST00000368722.1_Missense_Mutation_p.G92E	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	92					angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGCGCTGCTCCATGGCTCTG	0.517000													33	86					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66482982	66482982	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:66482982C>T	ENST00000359626.5	+	6	877	c.713C>T	c.(712-714)tCc>tTc	p.S238F		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	238					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				AAGTTCATCTCCCAGCTGCAG	0.547000													19	32					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77300426	77300426	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77300426G>C	ENST00000376896.2	+	10	1884	c.1272G>C	c.(1270-1272)ggG>ggC	p.G424G	RORB_ENST00000396204.2_Silent_p.G435G	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	435	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						ACTTGCACGGGGAGAAGCTGC	0.478000													41	125					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052768	15052768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15052768C>T	ENST00000248072.3	+	1	468	c.468C>T	c.(466-468)tcC>tcT	p.S156S		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TCATGGGTTCCTTGCTTGAGA	0.522000													78	172					0	0	1	0	0
HAPLN3	145864	broad.mit.edu	37	15	89430486	89430486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89430486G>A	ENST00000359595.3	-	2	258	c.44C>T	c.(43-45)tCc>tTc	p.S15F	HAPLN3_ENST00000562889.1_Missense_Mutation_p.S77F	NM_178232.2	NP_839946.1	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	15					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	17	Lung NSC(78;0.0392)|all_lung(78;0.077)					CAGTCCGTAGGAGCCGGGCAG	0.642000													41	55					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53222763	53222763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53222763G>A	ENST00000394729.2	+	15	1771	c.1443G>A	c.(1441-1443)ctG>ctA	p.L481L	PRKCD_ENST00000330452.3_Silent_p.L481L	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	481	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		ATGTGCTGCTGGACCGGGATG	0.557000													44	62					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531962	42531962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:42531962C>T	ENST00000282030.5	+	4	2953	c.2657C>T	c.(2656-2658)tCa>tTa	p.S886L		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	886						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GAGAAGAGCTCAGAATCCCGA	0.582000									Schinzel-Giedion syndrome				7	33					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348866	220348866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220348866G>A	ENST00000312358.7	+	30	6813	c.6681G>A	c.(6679-6681)aaG>aaA	p.K2227K	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2227	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GAGCCTCCAAGCCTGCACCAC	0.667000													13	54					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17452296	17452296	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17452296C>T	ENST00000324894.8	+	9	1331	c.1263C>T	c.(1261-1263)gaC>gaT	p.D421D	GTPBP3_ENST00000600625.1_Silent_p.D400D|GTPBP3_ENST00000358792.7_Silent_p.D453D|GTPBP3_ENST00000361619.5_Silent_p.D443D|GTPBP3_ENST00000598038.1_3'UTR	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	421					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						GGTGTGGGGACCCGTCCACAG	0.557000													21	64					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105423001	105423001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105423001G>A	ENST00000333244.5	-	4	358	c.239C>T	c.(238-240)tCt>tTt	p.S80F		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	80						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTCCCAGCAGAACCTTGCCT	0.617000													36	92					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440346	40440346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40440346C>T	ENST00000319592.4	-	4	1274	c.565G>A	c.(565-567)Gac>Aac	p.D189N	RBM47_ENST00000381793.2_Missense_Mutation_p.D189N|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381795.6_Missense_Mutation_p.D189N|RBM47_ENST00000514014.1_Missense_Mutation_p.D151N|RBM47_ENST00000295971.7_Missense_Mutation_p.D189N			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	189	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						TTCATCTTGTCGGCCGCGCTG	0.647000													41	70					0	0	1	0	0
TXNDC15	79770	broad.mit.edu	37	5	134229308	134229308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134229308C>T	ENST00000358387.4	+	3	1343	c.718C>T	c.(718-720)Ctt>Ttt	p.L240F	TXNDC15_ENST00000546290.1_Missense_Mutation_p.L217F	NM_024715.3	NP_078991.3	Q96J42	TXD15_HUMAN	thioredoxin domain containing 15	240	Thioredoxin.				cell redox homeostasis	integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATTTCCAGCTCTTCACTTTTT	0.522000													48	141					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64748576	64748576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:64748576G>A	ENST00000536360.1	-	5	1614	c.801C>T	c.(799-801)ggC>ggT	p.G267G				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	267	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TGTCTTTGCGGCCATGGTAGC	0.378000													39	111					0	0	1	0	0
ZNF618	114991	broad.mit.edu	37	9	116811507	116811507	+	Missense_Mutation	SNP	C	C	T	rs141487834	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116811507C>T	ENST00000288466.7	+	14	1745	c.1646C>T	c.(1645-1647)tCg>tTg	p.S549L	ZNF618_ENST00000470105.1_3'UTR|ZNF618_ENST00000374126.5_Missense_Mutation_p.S642L	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	642					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						GCCTTGAACTCGGTGGTGCAG	0.642000													7	57					0	0	1	0	0
ACTR3C	653857	broad.mit.edu	37	7	149986573	149986573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149986573G>A	ENST00000539352.1	-	4	514	c.263C>T	c.(262-264)cCt>cTt	p.P88L	ACTR3C_ENST00000252071.4_Missense_Mutation_p.P88L	NM_001164458.1	NP_001157930.1	Q9C0K3	ARP3C_HUMAN	ARP3 actin-related protein 3 homolog C (yeast)	88					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding										TGACTGCTCAGGAGGGATTCC	0.483000													4	20					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53932330	53932330	+	Missense_Mutation	SNP	G	G	A	rs141793483	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53932330G>A	ENST00000371445.3	+	4	1079	c.1024G>A	c.(1024-1026)Gac>Aac	p.D342N		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	342					sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						GGAGCAGTCCGACTAGGCCCC	0.567000													96	199					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26915838	26915838	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:26915838C>T	ENST00000231021.4	-	3	595	c.423G>A	c.(421-423)ccG>ccA	p.P141P		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	141	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						ATTCCGATTCCGGTTCCACCT	0.398000													68	186					0	0	1	0	0
SYT8	90019	broad.mit.edu	37	11	1856416	1856416	+	Silent	SNP	C	C	T	rs144532203	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1856416C>T	ENST00000535046.1	+	2	537	c.537C>T	c.(535-537)gtC>gtT	p.V179V	SYT8_ENST00000381968.3_Silent_p.V41V|SYT8_ENST00000341958.3_Silent_p.V27V|SYT8_ENST00000436964.2_Silent_p.V27V			Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	41	C2 1.					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CAGACCTTGTCGCCGGGACCC	0.622000													26	46					0	0	1	0	0
CLDN14	23562	broad.mit.edu	37	21	37833526	37833526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37833526C>T	ENST00000399137.1	-	3	1334	c.468G>A	c.(466-468)atG>atA	p.M156I	CLDN14_ENST00000399139.1_Missense_Mutation_p.M156I|CLDN14_ENST00000399135.1_Missense_Mutation_p.M156I|AP000695.6_ENST00000429588.1_RNA|CLDN14_ENST00000342108.2_Missense_Mutation_p.M156I|CLDN14_ENST00000399136.1_Missense_Mutation_p.M156I|AP000695.4_ENST00000428667.1_RNA	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	156					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						TCTCAAACTTCATGCCGCTGG	0.622000													28	64					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72724649	72724649	+	Missense_Mutation	SNP	G	G	A	rs146519251		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72724649G>A	ENST00000377182.4	+	4	1051	c.434G>A	c.(433-435)gGt>gAt	p.G145D	MAMDC2-AS1_ENST00000591368.1_RNA|MAMDC2-AS1_ENST00000414515.3_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	145	MAM 1.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						TTAATAGAAGGTGTACTAGGA	0.403000													23	154					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42375933	42375933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42375933C>T	ENST00000290472.3	-	7	610	c.516G>A	c.(514-516)ggG>ggA	p.G172G		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	172					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		CAGCGGTGCTCCCTGTGCTGT	0.627000													55	101					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97475240	97475240	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97475240G>A	ENST00000377075.2	+	7	2412	c.2314G>A	c.(2314-2316)Gag>Aag	p.E772K	CNNM4_ENST00000540067.1_3'UTR	NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	772					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						AGCCTCCCACGAGAATGCCAT	0.612000													14	28					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111430622	111430622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:111430622G>A	ENST00000428084.1	-	31	3478	c.3206C>T	c.(3205-3207)cCc>cTc	p.P1069L	DOCK4_ENST00000437633.1_Missense_Mutation_p.P1069L			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1069					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TTCTAGGAAGGGGCCAATCAG	0.403000													4	37					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20141519	20141519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20141519G>A	ENST00000375121.2	-	1	252	c.76C>T	c.(76-78)Cct>Tct	p.P26S	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	26						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCCAGCAGGGGCCACAGCG	0.652000													36	68					0	0	1	0	0
C15orf43	145645	broad.mit.edu	37	15	45249110	45249110	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45249110G>A	ENST00000340827.3	+	2	98	c.81G>A	c.(79-81)acG>acA	p.T27T		NM_152448.2	NP_689661.1	Q8NHR7	CO043_HUMAN	chromosome 15 open reading frame 43	27										NS(1)|breast(2)|large_intestine(1)|lung(2)|skin(2)	8		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		AAGGGGGAACGATCAGTGACC	0.587000													9	70					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13206217	13206217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13206217C>T	ENST00000379350.1	+	7	964	c.835C>T	c.(835-837)Ctg>Ttg	p.L279L	PHACTR1_ENST00000379345.2_Intron|PHACTR1_ENST00000457702.2_Silent_p.L134L|PHACTR1_ENST00000332995.7_Silent_p.L279L			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	279						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CCACACTGTCCTGCCCTCCCA	0.662000													29	57					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25255689	25255689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25255689G>A	ENST00000400358.4	+	9	865	c.808G>A	c.(808-810)Gac>Aac	p.D270N	SGSM1_ENST00000400359.4_Missense_Mutation_p.D270N	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	270						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						GCAGAGGGACGACATGGAGGC	0.562000													20	57					0	0	1	0	0
ZNF221	7638	broad.mit.edu	37	19	44470696	44470696	+	Missense_Mutation	SNP	C	C	T	rs150319141	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44470696C>T	ENST00000251269.5	+	6	1370	c.1042C>T	c.(1042-1044)Cgt>Tgt	p.R348C	ZNF221_ENST00000592350.1_Missense_Mutation_p.R348C|ZNF221_ENST00000587682.1_Missense_Mutation_p.R348C	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				CAAGAACTTTCGTCAGAGATC	0.408000													37	190					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12384283	12384283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12384283G>A	ENST00000356109.5	-	5	1049	c.931C>T	c.(931-933)Cct>Tct	p.P311S	ZNF44_ENST00000355684.5_Missense_Mutation_p.P263S	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		CTGTAATCAGGGAAGGCTTTA	0.408000													59	169					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33475234	33475234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:33475234C>T	ENST00000265371.4	-	15	2770	c.2245G>A	c.(2245-2247)Gat>Aat	p.D749N	NRP1_ENST00000374867.2_Missense_Mutation_p.D749N|NRP1_ENST00000395995.1_Missense_Mutation_p.D749N			O14786	NRP1_HUMAN	neuropilin 1	749	MAM.			D -> H (in Ref. 2; AAC12921).	axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	ACCAGCTGATCGTACTCCTCT	0.542000													20	50					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21793124	21793124	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21793124C>A	ENST00000206660.6	+	14	2110	c.2110C>A	c.(2110-2112)Cac>Aac	p.H704N	RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000382933.4_Intron|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.H704N|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.H666N|RPGRIP1_ENST00000307974.4_Missense_Mutation_p.H63N|RPGRIP1_ENST00000553500.1_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	704					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GCTTGACATACACCAGGCCAT	0.532000													51	127					4.44712e-29	4.47738e-29	1	1	0
UHRF1BP1	54887	broad.mit.edu	37	6	34789448	34789448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34789448C>T	ENST00000192788.5	+	2	234	c.63C>T	c.(61-63)tcC>tcT	p.S21S	UHRF1BP1_ENST00000452449.2_Silent_p.S21S	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	21										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						AGAATCTTTCCCCAGACAAAA	0.443000													5	60					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6511995	6511995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6511995C>T	ENST00000377828.1	+	10	2332	c.2164C>T	c.(2164-2166)Ccc>Tcc	p.P722S	ESPN_ENST00000461727.1_Missense_Mutation_p.P156S|ESPN_ENST00000475228.1_3'UTR|ESPN_ENST00000416731.1_Missense_Mutation_p.P156S	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	722	Pro-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding	p.P722S(1)		NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		AAGCTTGGTTCCCGTGCCGCC	0.672000													3	15					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197403884	197403884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197403884G>A	ENST00000367397.1	+	5	1892	c.1034G>A	c.(1033-1035)aGa>aAa	p.R345K	CRB1_ENST00000535699.1_Missense_Mutation_p.R940K|CRB1_ENST00000367400.3_Missense_Mutation_p.R964K|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000544212.1_Missense_Mutation_p.R445K|CRB1_ENST00000367399.2_Missense_Mutation_p.R852K			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	964	EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATATTATTCAGAAGCAATGGG	0.323000													38	87					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140926196	140926196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140926196C>T	ENST00000298296.1	+	1	95	c.95C>T	c.(94-96)tCc>tTc	p.S32F		NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	32										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					TATGCCTTATCCCCAGTGGTG	0.562000													60	38					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48565282	48565282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48565282G>A	ENST00000354276.3	-	14	1557	c.1230C>T	c.(1228-1230)ttC>ttT	p.F410F	PLA2G4C_ENST00000599921.1_Silent_p.F410F|PLA2G4C_ENST00000599111.1_Silent_p.F420F|CTD-2265M8.2_ENST00000601548.1_RNA|CTD-2265M8.2_ENST00000596552.1_RNA|PLA2G4C_ENST00000413144.2_Silent_p.F410F|CTD-2265M8.2_ENST00000601950.1_RNA|PLA2G4C_ENST00000596510.1_5'UTR	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	410	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CACTGAAGTCGAAGGAGAGGA	0.622000													49	104					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170503	58170503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58170503G>A	ENST00000309403.2	-	1	379	c.380C>T	c.(379-381)cCc>cTc	p.P127L		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTAATGTAGGGGTTTGCACAC	0.498000													46	104					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36130237	36130237	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36130237C>T	ENST00000303965.4	-	21	4047	c.3558G>A	c.(3556-3558)acG>acA	p.T1186T		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1186	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TCAACACAGCCGTCACATCTT	0.388000													20	56					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121631514	121631514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121631514G>A	ENST00000515109.1	-	13	1755	c.1499C>T	c.(1498-1500)cCt>cTt	p.P500L	PRDM5_ENST00000264808.3_Silent_p.L560L|PRDM5_ENST00000428209.2_Silent_p.L529L|PRDM5_ENST00000506065.1_5'UTR			Q9NQX1	PRDM5_HUMAN	PR domain containing 5	0					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TGCTCATCCAGGCCTCGCTTC	0.473000													17	35					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735888	41735888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41735888C>T	ENST00000352645.4	+	10	1142	c.885C>T	c.(883-885)ttC>ttT	p.F295F	ZC3H7B_ENST00000351589.4_Silent_p.F295F	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	311					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						TACCCGTGTTCCCCGGCGGGA	0.667000													29	101					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21856193	21856193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21856193G>A	ENST00000328843.6	+	65	10493	c.10462G>A	c.(10462-10464)Gaa>Aaa	p.E3488K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E3481K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3488	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AATGTCCACCGAAAATGCCGC	0.493000									Kartagener syndrome				15	27					0	0	1	0	0
SLC22A5	6584	broad.mit.edu	37	5	131729429	131729429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131729429C>T	ENST00000245407.3	+	9	1733	c.1512C>T	c.(1510-1512)atC>atT	p.I504I	SLC22A5_ENST00000435065.2_Silent_p.I528I	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	504					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	TGACAGCCATCCTCACCTTGT	0.552000													86	183					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979817	12979817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12979817G>A	ENST00000361079.2	+	4	1092	c.1009G>A	c.(1009-1011)Gag>Aag	p.E337K						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTTCAGCCCTGAGCCCCTCAC	0.582000													10	99					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118764380	118764380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118764380G>A	ENST00000292174.4	+	2	303	c.127G>A	c.(127-129)Ggg>Agg	p.G43R		NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	43					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TGCCACAGAGGGGCCCCTCAT	0.597000													30	102					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38307601	38307601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38307601C>T	ENST00000311856.4	+	1	299	c.250C>T	c.(250-252)Ctc>Ttc	p.L84F	SLC22A13_ENST00000450935.2_Missense_Mutation_p.L43F	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	84						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		AGAGCCCTGCCTCATGTTCCG	0.592000													5	36					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48267435	48267435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48267435G>A	ENST00000225964.5	-	36	2604	c.2486C>T	c.(2485-2487)cCt>cTt	p.P829L		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	829	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	AGCATCACCAGGTTCGCCTTT	0.657000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						29	65					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178936259	178936259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:178936259G>A	ENST00000286063.5	-	1	1223	c.906C>T	c.(904-906)gcC>gcT	p.A302A	PDE11A_ENST00000358450.4_Intron	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	302	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CTACCTGGTAGGCATCAGGAA	0.512000									Primary Pigmented Nodular Adrenocortical Disease, Familial				10	141					0	0	1	0	0
CDK14	5218	broad.mit.edu	37	7	90355918	90355918	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:90355918G>A	ENST00000406263.1	+	2	465	c.23G>A	c.(22-24)gGa>gAa	p.G8E	CDK14_ENST00000436577.2_5'UTR|CDK14_ENST00000380050.3_Missense_Mutation_p.G54E|CDK14_ENST00000265741.3_Missense_Mutation_p.G36E|CDK14_ENST00000496279.1_3'UTR			O94921	CDK14_HUMAN	cyclin-dependent kinase 14	54				Q -> R (in Ref. 3; BAG60284).	cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(12)|ovary(1)|skin(4)	32						AACTGCCAGGGAATGGACTCA	0.408000													8	79					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	114009781	114009781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:114009781C>T	ENST00000375430.4	-	3	243	c.197G>A	c.(196-198)cGg>cAg	p.R66Q	GRTP1-AS1_ENST00000423246.1_RNA|GRTP1-AS1_ENST00000419199.1_RNA|GRTP1_ENST00000375431.4_Missense_Mutation_p.R66Q			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	66						intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GACCCCTTTCCGGACATAGCG	0.657000													3	25					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907641	12907641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12907641C>T	ENST00000317869.6	-	2	727	c.502G>A	c.(502-504)Gga>Aga	p.G168R		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TTGGAAGATCCCCGCTTTCCA	0.478000													102	508					0	0	1	0	0
ZNF567	163081	broad.mit.edu	37	19	37211306	37211306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37211306C>T	ENST00000585696.1	+	3	2817	c.1587C>T	c.(1585-1587)tcC>tcT	p.S529S	ZNF567_ENST00000588311.1_Silent_p.S529S|ZNF567_ENST00000392163.2_Silent_p.S529S|ZNF567_ENST00000360729.4_Silent_p.S529S|ZNF567_ENST00000536254.2_Silent_p.S560S|ZNF850_ENST00000589390.1_Intron			Q8N184	ZN567_HUMAN	zinc finger protein 567	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GCCAGAAATCCTATGAATGTC	0.413000													11	114					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97918838	97918838	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97918838C>T	ENST00000534948.1	+	0	3616							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		ATGCAGAGTCCACTTTTAAAT	0.333000													5	52					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915535	119915535	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:119915535G>A	ENST00000331113.4	+	1	1814	c.849G>A	c.(847-849)gaG>gaA	p.E283E		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	283					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CAGACAATGAGGACGTCAGCG	0.537000													17	38					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61941113	61941113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61941113C>T	ENST00000280772.1	-	18	2349	c.2158G>A	c.(2158-2160)Ggg>Agg	p.G720R	ANK3_ENST00000503366.1_Missense_Mutation_p.G703R|ANK3_ENST00000373827.2_Missense_Mutation_p.G714R	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	720					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACATGAGCCCCTTGGTTTACG	0.498000													36	143					0	0	1	0	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95374429	95374429	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:95374429G>A	ENST00000494840.1	-	0	1432					NR_077228.1																						AAGCATTGCAGATCTTTCTCT	0.398000													23	90					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	42080468	42080468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42080468G>A	ENST00000400454.1	-	2	750	c.273C>T	c.(271-273)ttC>ttT	p.F91F		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	91	Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTAAGGTACTGAAGCTTGAAG	0.498000													41	109					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167056312	167056312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167056312G>A	ENST00000375387.4	-	27	5180	c.4840C>T	c.(4840-4842)Cgt>Tgt	p.R1614C	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.R1602C|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1613C|SCN9A_ENST00000303354.6_Missense_Mutation_p.R1614C			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1613						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CTGGCAAGACGGATCACTCGG	0.428000													47	133					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90179560	90179560	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:90179560T>C	ENST00000370454.4	+	3	1686	c.1431T>C	c.(1429-1431)tgT>tgC	p.C477C	LRRC8C_ENST00000479252.1_Intron|RP11-302M6.4_ENST00000370453.5_Intron	NM_032270.4	NP_115646.2	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	477						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		TGCACCAGTGTTCTGTCAAAA	0.463000													36	86					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13737473	13737473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13737473G>A	ENST00000265104.4	-	66	11447	c.11343C>T	c.(11341-11343)ctC>ctT	p.L3781L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3781	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCACGACAATGAGACTTTCAT	0.453000									Kartagener syndrome				45	119					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537328	55537328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55537328C>T	ENST00000220676.1	+	4	1034	c.886C>T	c.(886-888)Cct>Tct	p.P296S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	296					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCTTTTGTTCCTGAAAAGTA	0.318000													17	55					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153652232	153652232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153652232C>T	ENST00000368680.3	+	1	1120	c.648C>T	c.(646-648)gaC>gaT	p.D216D		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	216					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TTACGGTGGACCACCTGGAGT	0.652000													4	10					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5758549	5758549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5758549C>T	ENST00000317121.3	+	1	869	c.803C>T	c.(802-804)tCa>tTa	p.S268L	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		GTAGTGATTTCAGTGACTCAT	0.443000													107	276					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169842736	169842736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169842736C>T	ENST00000263817.6	-	10	1091	c.967G>A	c.(967-969)Gga>Aga	p.G323R		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	323	ABC transmembrane type-1 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GTAAAGAATCCCATCACTATT	0.443000													12	112					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140494159	140494159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:140494159G>A	ENST00000288602.6	-	8	1149	c.1089C>T	c.(1087-1089)tcC>tcT	p.S363S		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	363					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GAGCTGATGAGGATCGGTCTC	0.408000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				33	93					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772551	4772551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:4772551C>T	ENST00000378191.4	+	2	1002	c.621C>T	c.(619-621)tcC>tcT	p.S207S	AJAP1_ENST00000378190.3_Silent_p.S207S	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	207	Thr-rich.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CCACGGTCTCCATCCTACAAA	0.637000													8	21					0	0	1	0	0
OR10W1	81341	broad.mit.edu	37	11	58034458	58034458	+	Silent	SNP	G	G	A	rs146836599		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58034458G>A	ENST00000395079.2	-	1	1274	c.873C>T	c.(871-873)gcC>gcT	p.A291A		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				CTCTCCCTACGGCCCCTTTCA	0.517000													34	82					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20534356	20534356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:20534356C>T	ENST00000377252.3	+	13	2236	c.1395C>T	c.(1393-1395)ctC>ctT	p.L465L	PLXDC2_ENST00000377238.2_3'UTR|PLXDC2_ENST00000377242.3_Silent_p.L416L	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	465						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						TCCTGGTCCTCATTGTAGCCA	0.473000													60	149					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14775702	14775702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:14775702G>A	ENST00000403951.2	-	5	705	c.286C>T	c.(286-288)Cca>Tca	p.P96S	DGKB_ENST00000402815.1_Missense_Mutation_p.P96S|DGKB_ENST00000258767.5_Missense_Mutation_p.P96S|DGKB_ENST00000444700.2_Missense_Mutation_p.P89S|DGKB_ENST00000399322.3_Missense_Mutation_p.P96S|DGKB_ENST00000407950.1_Missense_Mutation_p.P89S|DGKB_ENST00000406247.3_Missense_Mutation_p.P96S|DGKB_ENST00000403963.1_5'UTR			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	96					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TTTACCATTGGACTAGAATGA	0.348000													4	14					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40283671	40283671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40283671C>T	ENST00000325157.6	-	2	332	c.82G>A	c.(82-84)Gac>Aac	p.D28N		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	28	ENTH.							p.D28N(1)|p.D28Y(1)		breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					CCCCAAGGGTCGTTAGAAGTT	0.393000													51	100					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256493	63256493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:63256493C>T	ENST00000323865.3	-	1	1287	c.1054G>A	c.(1054-1056)Ggc>Agc	p.G352S	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	352					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ATGAAGGTGCCCATGATGATG	0.592000													21	156					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96055276	96055276	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96055276C>T	ENST00000356055.3	+	23	5522	c.615_splice	c.e23-1	p.S206_splice	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Silent_p.F1455F|WNK2_ENST00000349097.3_Silent_p.F1492F|WNK2_ENST00000395477.2_Silent_p.F1843F|WNK2_ENST00000297954.4_Silent_p.F1880F			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1879	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CCACCGCCTTCCTGCAGAGGC	0.692000													8	20					0	0	1	0	0
EPS8L2	64787	broad.mit.edu	37	11	724744	724744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:724744C>T	ENST00000533256.1	+	17	1850	c.1475C>T	c.(1474-1476)gCc>gTc	p.A492V	EPS8L2_ENST00000526198.1_Missense_Mutation_p.A508V|EPS8L2_ENST00000530636.1_Missense_Mutation_p.A492V|EPS8L2_ENST00000318562.8_Missense_Mutation_p.A492V|AP006621.9_ENST00000527021.2_RNA			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	492	SH3.					cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCAACACCAGCCATGGCCAAG	0.617000													20	41					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14747004	14747004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14747004C>T	ENST00000380881.4	-	35	6873	c.6058G>A	c.(6058-6060)Gga>Aga	p.G2020R	FREM1_ENST00000380894.1_Missense_Mutation_p.G555R|FREM1_ENST00000422223.2_Missense_Mutation_p.G2019R|FREM1_ENST00000380880.3_Missense_Mutation_p.G2019R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	2019					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TGGAAGAGTCCCTTTAATTCC	0.468000													6	23					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	22005007	22005007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22005007C>T	ENST00000327430.3	-	1	343	c.49G>A	c.(49-51)Gaa>Aaa	p.E17K	SALL2_ENST00000317492.5_Missense_Mutation_p.E17K	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	17							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CTGGGACCTTCGCAGTCCGAG	0.632000													24	45					0	0	1	0	0
DHDH	27294	broad.mit.edu	37	19	49442727	49442727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49442727C>T	ENST00000221403.2	+	4	428	c.388C>T	c.(388-390)Cct>Tct	p.P130S	DHDH_ENST00000522614.1_Missense_Mutation_p.P130S|DHDH_ENST00000523250.1_Intron	NM_014475.3	NP_055290.1	Q9UQ10	DHDH_HUMAN	dihydrodiol dehydrogenase (dimeric)	130					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			central_nervous_system(1)|large_intestine(3)|lung(3)|ovary(1)|soft_tissue(1)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		CCGCTTCTTTCCTGCCTCCGA	0.567000													59	101					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052800	15052800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15052800C>T	ENST00000248072.3	+	1	500	c.500C>T	c.(499-501)tCc>tTc	p.S167F		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TTGAGGCTGTCCTTCTGCACA	0.488000													96	182					0	0	1	0	0
DPPA5	340168	broad.mit.edu	37	6	74063623	74063623	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:74063623C>T	ENST00000370370.3	-	2	314	c.245G>A	c.(244-246)tGg>tAg	p.W82*		NM_001025290.2	NP_001020461.1	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	82	KH; atypical.				multicellular organismal development	cytoplasm	RNA binding			NS(1)|endometrium(1)|lung(5)	7						CTGGAGCATCCACTTGGTCCG	0.627000													7	31					0	0	1	0	0
DPH7	92715	broad.mit.edu	37	9	140468793	140468793	+	Silent	SNP	G	G	A	rs140349182	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140468793G>A	ENST00000277540.2	-	5	664	c.507C>T	c.(505-507)tcC>tcT	p.S169S	DPH7_ENST00000479650.1_5'UTR	NM_138778.2	NP_620133.1			diphthamide biosynthesis 7																		GCTGCCCTGTGGAGTCACTGC	0.567000													9	109					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216737577	216737577	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216737577C>T	ENST00000391890.3	-	7	1315	c.798G>A	c.(796-798)tgG>tgA	p.W266*	ESRRG_ENST00000493748.1_Nonsense_Mutation_p.W259*|ESRRG_ENST00000366940.2_Nonsense_Mutation_p.W259*|ESRRG_ENST00000487276.1_Nonsense_Mutation_p.W259*|ESRRG_ENST00000361525.3_Nonsense_Mutation_p.W259*|ESRRG_ENST00000408911.3_Nonsense_Mutation_p.W282*|ESRRG_ENST00000366937.1_Nonsense_Mutation_p.W294*|ESRRG_ENST00000359162.2_Nonsense_Mutation_p.W259*|ESRRG_ENST00000360012.3_Nonsense_Mutation_p.W259*|ESRRG_ENST00000493603.1_Nonsense_Mutation_p.W259*|ESRRG_ENST00000361395.2_Nonsense_Mutation_p.W259*|ESRRG_ENST00000463665.1_Nonsense_Mutation_p.W220*|ESRRG_ENST00000366938.2_Nonsense_Mutation_p.W259*	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	282					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TATGCTTCGCCCATCCAATGA	0.423000													28	60					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238445	3238445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3238445C>T	ENST00000217939.6	-	5	5435	c.5281G>A	c.(5281-5283)Gag>Aag	p.E1761K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1761						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACTTTTCTCTCTCTCATTACT	0.507000													18	11					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26228957	26228957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26228957C>T	ENST00000335473.7	+	16	3303	c.3053C>T	c.(3052-3054)cCc>cTc	p.P1018L	MYO18B_ENST00000536101.1_Missense_Mutation_p.P1018L|MYO18B_ENST00000407587.2_Missense_Mutation_p.P1018L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1018	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GATCAAAATCCCTCTCAGGTA	0.498000													27	69					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327454	57327454	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57327454C>T	ENST00000326441.9	-	10	2719	c.2356G>A	c.(2356-2358)Gaa>Aaa	p.E786K	PEG3_ENST00000423103.2_Missense_Mutation_p.E786K|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.E660K|PEG3_ENST00000598410.1_Missense_Mutation_p.E662K|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	786					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCTGAGCTTCCACAGAGGCT	0.433000													85	204					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52591936	52591936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:52591936C>T	ENST00000395961.3	-	8	1340	c.1174G>A	c.(1174-1176)Gag>Aag	p.E392K	BCAS1_ENST00000434986.2_Intron|BCAS1_ENST00000371440.3_Intron|BCAS1_ENST00000371435.2_Missense_Mutation_p.E392K	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	392						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			ACATTCTCCTCCGCACCTGTG	0.413000													11	33					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183498122	183498122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183498122C>T	ENST00000367537.3	+	8	934	c.739C>T	c.(739-741)Cct>Tct	p.P247S	SMG7_ENST00000347615.2_Missense_Mutation_p.P218S|SMG7_ENST00000508461.1_Missense_Mutation_p.P176S|SMG7_ENST00000507469.1_Missense_Mutation_p.P218S|SMG7_ENST00000515829.2_Missense_Mutation_p.P218S|SMG7_ENST00000456731.2_Missense_Mutation_p.P176S|SMG7_ENST00000507406.1_3'UTR			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	218					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						TGTGAAGTTCCCTTTCCCAGC	0.418000													37	104					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8214429	8214429	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8214429C>T	ENST00000539824.1	+	4	395	c.19_splice	c.e4-1	p.D7_splice	SH3TC1_ENST00000245105.3_Splice_Site_p.D83_splice			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	83							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						CCCCTCCAGACCTGACCCTGC	0.652000													11	15					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42298192	42298192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42298192G>A	ENST00000399518.3	-	4	1007	c.521C>T	c.(520-522)cCg>cTg	p.P174L	PLA2G4E_ENST00000413860.2_Missense_Mutation_p.P145L	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	156					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		ACCCACCTGCGGGTTGAGTGG	0.522000													11	47					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40357727	40357727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40357727C>T	ENST00000221347.6	-	34	15593	c.15586G>A	c.(15586-15588)Gag>Aag	p.E5196K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5196	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAACAGCGCTCGCTGCAGTCT	0.587000													16	38					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138999	126138999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:126138999C>T	ENST00000299308.3	+	9	2988	c.2980C>T	c.(2980-2982)Cat>Tat	p.H994Y	TMEM132B_ENST00000535886.1_Missense_Mutation_p.H506Y	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	994						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAAGACTTTTCATAGTCAACT	0.448000													13	27					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932393	83932393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83932393G>A	ENST00000345382.2	-	4	1695	c.1610C>T	c.(1609-1611)tCc>tTc	p.S537F	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.S530F	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	537					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						GGACTTCCTGGATTTCTTCTT	0.463000													14	145					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113999136	113999136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113999136C>T	ENST00000429538.3	-	7	963	c.769G>A	c.(769-771)Ggc>Agc	p.G257S	AC016683.6_ENST00000333145.5_RNA|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000263335.7_Missense_Mutation_p.G257S|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000451179.1_RNA|PAX8_ENST00000397647.3_Missense_Mutation_p.G257S|PAX8_ENST00000348715.5_Missense_Mutation_p.G257S|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000422956.1_RNA|PAX8_ENST00000263334.5_Missense_Mutation_p.G257S	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	257					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						ACCTGCTCGCCTTTGGTGTGG	0.617000			T	PPARG	follicular thyroid		Thyroid dysgenesis						6	4					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18188342	18188342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18188342C>T	ENST00000600835.1	-	6	836	c.533G>A	c.(532-534)aGc>aAc	p.S178N	IL12RB1_ENST00000593993.1_Missense_Mutation_p.S178N|IL12RB1_ENST00000430026.2_Missense_Mutation_p.S178N|IL12RB1_ENST00000322153.6_Missense_Mutation_p.S178N			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	178	Fibronectin type-III 2.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCATGGGCTGCTGGGTGTCCG	0.597000													8	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179599285	179599285	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179599285C>T	ENST00000589042.1	-	52	15490	c.15266G>A	c.(15265-15267)gGa>gAa	p.G5089E	TTN_ENST00000342992.6_Missense_Mutation_p.G3845E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G4772E|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4772	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCATTTGTTCCTCTCACTAT	0.363000													30	134					0	0	1	0	0
SAFB2	9667	broad.mit.edu	37	19	5612564	5612564	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5612564G>A	ENST00000252542.4	-	6	885	c.621C>T	c.(619-621)tcC>tcT	p.S207S		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GCTCCAAAAGGGATTCTTCAA	0.338000													6	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179635143	179635143	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179635143C>T	ENST00000589042.1	-	35	8600	c.8376G>A	c.(8374-8376)gtG>gtA	p.V2792V	TTN_ENST00000342992.6_Silent_p.V2792V|TTN_ENST00000360870.5_Silent_p.V2792V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V2746V|TTN_ENST00000342175.6_Silent_p.V2746V|TTN_ENST00000359218.5_Silent_p.V2746V|TTN_ENST00000591111.1_Silent_p.V2792V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2530							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTACTCTCCACGTGCAGTC	0.438000													23	77					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179554594	179554594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179554594C>T	ENST00000589042.1	-	122	32016	c.31792G>A	c.(31792-31794)Gaa>Aaa	p.E10598K	TTN_ENST00000342992.6_Missense_Mutation_p.E9354K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10281K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10281	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTTTCTTCAGGGACAGGT	0.403000													75	218					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117553124	117553124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117553124C>T	ENST00000374045.4	-	4	477	c.364G>A	c.(364-366)Gaa>Aaa	p.E122K	TNFSF15_ENST00000374044.1_Missense_Mutation_p.E45K	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	122					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						AGGCCTAGTTCATGTTCCCAG	0.448000													21	66					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222729	140222729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140222729C>T	ENST00000531613.1	+	1	1823	c.1823C>T	c.(1822-1824)tCg>tTg	p.S608L	PCDHA8_ENST00000378123.3_Missense_Mutation_p.S608L|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1												p.S608L(4)		NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGGCTTTCGTATGAGCTG	0.682000													20	29					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117079486	117079486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117079486C>T	ENST00000262820.3	-	2	1060	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K	KLHL13_ENST00000371882.1_5'UTR|KLHL13_ENST00000539496.1_Missense_Mutation_p.E54K|KLHL13_ENST00000540167.1_Missense_Mutation_p.E35K|KLHL13_ENST00000545703.1_Missense_Mutation_p.E9K|KLHL13_ENST00000541812.1_Missense_Mutation_p.E35K|KLHL13_ENST00000371878.1_5'UTR|KLHL13_ENST00000469946.1_5'UTR|KLHL13_ENST00000371876.1_5'UTR	NM_033495.3	NP_277030.2	Q9P2N7	KLH13_HUMAN	kelch-like family member 13	51					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AGGCCCATTTCGCTGCCTCCA	0.433000													14	23					0	0	1	0	0
AGPAT9	84803	broad.mit.edu	37	4	84519293	84519293	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:84519293C>T	ENST00000395226.2	+	11	1304	c.1086C>T	c.(1084-1086)atC>atT	p.I362I	AGPAT9_ENST00000264409.4_Silent_p.I362I	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	362					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				GCTGGGCCATCGTCTGTGACG	0.448000													31	76					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212180634	212180634	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:212180634G>A	ENST00000366994.3	-	6	818	c.714C>T	c.(712-714)ttC>ttT	p.F238F	INTS7_ENST00000366993.3_Silent_p.F238F|INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000366992.3_Silent_p.F238F|INTS7_ENST00000440600.2_Silent_p.F189F	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	238					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CAAGCAGAGTGAAAGTGTGCA	0.398000													22	42					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36150108	36150108	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36150108G>A	ENST00000303965.4	-	17	3408	c.2919C>T	c.(2917-2919)atC>atT	p.I973I		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	973	PH 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGGGTAAGTAGATCTCAAAGA	0.328000													15	42					0	0	1	0	0
COQ3	51805	broad.mit.edu	37	6	99819417	99819417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:99819417G>A	ENST00000254759.3	-	6	800	c.776C>T	c.(775-777)tCc>tTc	p.S259F	COQ3_ENST00000369240.1_Missense_Mutation_p.S31F|COQ3_ENST00000369242.1_Missense_Mutation_p.S31F	NM_017421.3	NP_059117.3	Q9NZJ6	COQ3_HUMAN	coenzyme Q3 methyltransferase	259					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			cervix(1)|lung(5)|upper_aerodigestive_tract(2)	8		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		CAAGGCATAGGAAAGTTGTGT	0.338000													23	30					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155198856	155198856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155198856G>A	ENST00000460012.1	-	23	5226	c.4869C>T	c.(4867-4869)caC>caT	p.H1623H	PLCH1_ENST00000334686.6_Silent_p.H1623H|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000340059.7_Silent_p.H1661H|PLCH1_ENST00000414191.1_Silent_p.H1623H			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1661					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CGTGGCCATAGTGAAGAGCCG	0.507000													24	28					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106456510	106456510	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106456510G>A	ENST00000520492.1	+	0	374				ZFPM2_ENST00000407775.2_Missense_Mutation_p.D68N			Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2						blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TTTTCCAGGTGATGATGAAGG	0.463000													6	16					0	0	1	0	0
SLC25A38	54977	broad.mit.edu	37	3	39433010	39433010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39433010C>T	ENST00000273158.4	+	4	732	c.355C>T	c.(355-357)Cat>Tat	p.H119Y		NM_017875.2	NP_060345.2	Q96DW6	S2538_HUMAN	solute carrier family 25, member 38	119					erythrocyte differentiation|heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CTTGCGAGGCCATCCCCCAAC	0.532000													28	341					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254708	51254708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:51254708G>A	ENST00000404971.1	-	2	2043	c.704C>T	c.(703-705)tCc>tTc	p.S235F	NRXN1_ENST00000405581.1_Missense_Mutation_p.S235F|NRXN1_ENST00000402717.3_Missense_Mutation_p.S235F|NRXN1_ENST00000401669.2_Missense_Mutation_p.S235F|NRXN1_ENST00000406859.3_Missense_Mutation_p.S235F|NRXN1_ENST00000405472.3_Missense_Mutation_p.S235F|NRXN1_ENST00000406316.2_Missense_Mutation_p.S235F	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	235	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GTCCACCACGGAGCACACACC	0.726000													15	19					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166959017	166959017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:166959017G>A	ENST00000367872.4	+	2	420	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	MAEL_ENST00000367870.2_Intron	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	59					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						GAAATGGCTCGAGAATGGAGG	0.527000													11	32					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43927322	43927322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43927322C>T	ENST00000282406.4	+	8	1335	c.1225C>T	c.(1225-1227)Cct>Tct	p.P409S		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	409						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CACCCCAAGCCCTATTTTGAC	0.423000													35	94					0	0	1	0	0
RDH8	50700	broad.mit.edu	37	19	10132058	10132058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10132058C>T	ENST00000591589.1	+	5	913	c.724C>T	c.(724-726)Cca>Tca	p.P242S	RDH8_ENST00000171214.1_Missense_Mutation_p.P222S			Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	222					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			endometrium(3)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|prostate(1)	21			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	CCTCTATCTCCCAGCCTCCAG	0.587000													33	103					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85971439	85971439	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85971439G>A	ENST00000372117.3	+	14	1624	c.1521G>A	c.(1519-1521)gtG>gtA	p.V507V	CDHR1_ENST00000440770.2_Silent_p.V211V|CDHR1_ENST00000332904.3_Silent_p.V507V	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	507	Cadherin 5.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						GGGGCGAAGTGAAATATTCCA	0.572000													64	145					0	0	1	0	0
ACTG2	72	broad.mit.edu	37	2	74141990	74141990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74141990C>T	ENST00000409624.1	+	8	1440	c.797C>T	c.(796-798)tCc>tTc	p.S266F	ACTG2_ENST00000409731.3_Missense_Mutation_p.S223F|ACTG2_ENST00000345517.3_Missense_Mutation_p.S266F			P63267	ACTH_HUMAN	actin, gamma 2, smooth muscle, enteric	266					muscle contraction	cytoskeleton|cytosol	ATP binding			large_intestine(3)|lung(14)|skin(1)	18						TTCCAGCCTTCCTTTATTGGT	0.577000													20	61					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26089961	26089961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26089961G>A	ENST00000313735.6	-	22	2896	c.2663C>T	c.(2662-2664)tCc>tTc	p.S888F		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	888	FAD-binding FR-type.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CACCCGCAGGGACGGGAACTC	0.572000													5	7					0	0	1	0	0
FFAR1	2864	broad.mit.edu	37	19	35842810	35842810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35842810G>A	ENST00000246553.2	+	1	366	c.356G>A	c.(355-357)aGg>aAg	p.R119K		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	119					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GCCTTCCGGAGGCCGTGCTAT	0.672000													22	51					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422713	26422713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26422713G>A	ENST00000335473.7	+	43	7023	c.6773G>A	c.(6772-6774)cGg>cAg	p.R2258Q	MYO18B_ENST00000536101.1_Missense_Mutation_p.R2258Q|MYO18B_ENST00000407587.2_Missense_Mutation_p.R2259Q	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2258						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GAAGGGCTCCGGAGGAAGAGA	0.627000													12	17					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29364623	29364623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29364623C>T	ENST00000383555.2	+	1	208	c.147C>T	c.(145-147)tcC>tcT	p.S49S	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						TTGTCATCTCCGATCCTAGAC	0.458000													23	97					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46782321	46782321	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46782321G>A	ENST00000262738.3	-	19	6716	c.6717C>T	c.(6715-6717)ttC>ttT	p.F2239F		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2239					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGACGATGACGAAGGGCCGCA	0.677000													6	10					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110456078	110456078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110456078G>A	ENST00000378402.5	+	37	4842	c.4738G>A	c.(4738-4740)Gaa>Aaa	p.E1580K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1580	IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AACAGTAAATGAACTAATAAC	0.328000										HNSCC(38;0.096)			49	64					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28909943	28909943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28909943C>T	ENST00000257192.4	+	5	673	c.461C>T	c.(460-462)cCt>cTt	p.P154L		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	154	Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AATGACAACCCTCCAGTGTTT	0.433000													23	98					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62648700	62648700	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:62648700G>A	ENST00000337910.5	-	6	1063	c.726C>T	c.(724-726)gtC>gtT	p.V242V	RHOBTB1_ENST00000357917.4_Silent_p.V242V	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	242					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					GAATTTTGATGACCGGTGGAG	0.498000													19	169					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192327	132192327	+	Missense_Mutation	SNP	G	G	A	rs151233036		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:132192327G>A	ENST00000359827.3	-	2	2088	c.1126C>T	c.(1126-1128)Cgg>Tgg	p.R376W	PLXNA4_ENST00000423507.2_Missense_Mutation_p.R376W|PLXNA4_ENST00000378539.5_Missense_Mutation_p.R376W|PLXNA4_ENST00000321063.4_Missense_Mutation_p.R376W			Q9HCM2	PLXA4_HUMAN	plexin A4	376	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCCTCGCCCCGGTAACAAGAC	0.587000													7	87					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236908011	236908011	+	Silent	SNP	C	C	T	rs34785693	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236908011C>T	ENST00000366578.4	+	12	1507	c.1341C>T	c.(1339-1341)ttC>ttT	p.F447F	ACTN2_ENST00000542672.1_Silent_p.F447F|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_5'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	447					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			ACGAGGCGTTCGAGAGCGACC	0.637000													40	21					0	0	1	0	0
TRAV6	6956	broad.mit.edu	37	14	22237162	22237162	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22237162G>A	ENST00000390428.3	+	0	246																											CAAGATCCAGGAAGAGGCCCT	0.453000													28	69					0	0	1	0	0
C4BPB	725	broad.mit.edu	37	1	207262917	207262917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207262917G>A	ENST00000243611.5	+	1	335	c.41G>A	c.(40-42)cGa>cAa	p.R14Q	C4BPB_ENST00000367076.3_Missense_Mutation_p.R14Q|C4BPB_ENST00000367078.3_Missense_Mutation_p.R14Q|C4BPB_ENST00000451804.2_Missense_Mutation_p.R5Q|C4BPB_ENST00000391923.1_Missense_Mutation_p.R14Q	NM_000716.3	NP_000707.1	P20851	C4BPB_HUMAN	complement component 4 binding protein, beta	14					blood coagulation|complement activation, classical pathway|innate immune response	extracellular region				breast(2)|lung(1)|ovary(1)	4						GTTGCGTGGCGAGTTTCTGCT	0.478000													17	43					0	0	1	0	0
ZNF490	57474	broad.mit.edu	37	19	12691844	12691844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12691844G>A	ENST00000311437.6	-	5	1167	c.1045C>T	c.(1045-1047)Ctt>Ttt	p.L349F		NM_020714.2	NP_065765.1	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	18						TGTTTTCGAAGGCTTGAGTGA	0.448000													27	108					0	0	1	0	0
PPP1R1A	5502	broad.mit.edu	37	12	54976578	54976578	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54976578G>A	ENST00000257905.8	-	4	355	c.183_splice	c.e4-1	p.S62_splice	PPP1R1A_ENST00000547431.1_Intron	NM_006741.3	NP_006732.3	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1A	62					glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			lung(2)	2						TGCCAAAGTGGACTGTGAAGG	0.597000													25	43					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8657649	8657649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8657649C>T	ENST00000270328.4	-	12	1851	c.1585G>A	c.(1585-1587)Ggg>Agg	p.G529R	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.G529R			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	529	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GCGCTCACCCCCTTGTCGATG	0.682000													3	14					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98209620	98209620	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:98209620G>A	ENST00000430669.2	-	23	4305	c.3720C>T	c.(3718-3720)ccC>ccT	p.P1240P	PTCH1_ENST00000331920.6_Silent_p.P1306P|PTCH1_ENST00000375274.2_Silent_p.P1305P|PTCH1_ENST00000437951.1_Silent_p.P1240P|PTCH1_ENST00000421141.1_Silent_p.P1155P|PTCH1_ENST00000429896.2_Silent_p.P1155P|PTCH1_ENST00000418258.1_Silent_p.P1155P			Q13635	PTC1_HUMAN	patched 1	1306					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CTTCTCTGGGGGGGTCCCTGC	0.647000													28	63					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32698944	32698944	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32698944C>T	ENST00000380250.3	+	7	1144	c.648C>T	c.(646-648)ccC>ccT	p.P216P		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACCTTGGTCCCAACACTGGCA	0.428000													14	149					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37602816	37602816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37602816C>T	ENST00000328544.3	-	2	1560	c.1027G>A	c.(1027-1029)Ggg>Agg	p.G343R	SSTR3_ENST00000402501.1_Missense_Mutation_p.G343R	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	343					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						TCCGGGGGCCCCACAGTGGGC	0.672000													18	66					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3174071	3174071	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3174071C>T	ENST00000355072.5	+	30	4034	c.3889C>T	c.(3889-3891)Ctg>Ttg	p.L1297L		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1297					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCTAGGATACCTGAAATCCTG	0.408000													11	126					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14799050	14799050	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14799050C>T	ENST00000253697.3	+	13	2565	c.2113C>T	c.(2113-2115)Cga>Tga	p.R705*	C3orf20_ENST00000412910.1_Nonsense_Mutation_p.R583*|C3orf20_ENST00000435614.1_Nonsense_Mutation_p.R583*	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	705						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GTTGGCGCCCCGAGACCCCAG	0.602000													16	40					0	0	1	0	0
APBB2	323	broad.mit.edu	37	4	40946922	40946922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40946922G>A	ENST00000295974.8	-	7	1630	c.1001C>T	c.(1000-1002)tCa>tTa	p.S334L	APBB2_ENST00000506352.1_Missense_Mutation_p.S334L|APBB2_ENST00000513140.1_Missense_Mutation_p.S334L|APBB2_ENST00000508593.1_Missense_Mutation_p.S335L	NM_001166050.1|NM_004307.1	NP_001159522.1|NP_004298.1	Q92870	APBB2_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 2	334					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(3)|skin(2)|urinary_tract(1)	34						AGAACTAAGTGACCCTTTCCT	0.493000													20	87					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181549743	181549743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181549743G>A	ENST00000526775.1	+	6	947	c.782G>A	c.(781-783)gGa>gAa	p.G261E	CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000358338.5_Missense_Mutation_p.G212E|CACNA1E_ENST00000367570.1_Missense_Mutation_p.G261E|CACNA1E_ENST00000360108.3_Missense_Mutation_p.G261E|CACNA1E_ENST00000367573.2_Missense_Mutation_p.G261E|CACNA1E_ENST00000357570.5_Missense_Mutation_p.G212E	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	261					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ATTCTAGAAGGATTTGACCCC	0.507000													50	135					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47228866	47228866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47228866G>A	ENST00000391910.3	-	10	1759	c.1309C>T	c.(1309-1311)Ccc>Tcc	p.P437S	STRN4_ENST00000539396.1_Missense_Mutation_p.P311S|STRN4_ENST00000263280.6_Missense_Mutation_p.P430S|STRN4_ENST00000594357.2_5'UTR			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	430						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GTGAACTTGGGGTTCCACGTC	0.602000													14	39					0	0	1	0	0
OR7A17	26333	broad.mit.edu	37	19	14991526	14991526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14991526G>A	ENST00000327462.2	-	1	738	c.642C>T	c.(640-642)atC>atT	p.I214I		NM_030901.1	NP_112163.1	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A, member 17	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12	Ovarian(108;0.203)					AAGAGCAAAGGATCCCCACAA	0.488000													44	124					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202114	140202114	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140202114G>A	ENST00000529859.1	+	1	754	c.754G>A	c.(754-756)Gaa>Aaa	p.E252K	PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.E252K|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.E252K	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATTGTTGGAAAATGCACC	0.363000													25	104					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189065004	189065004	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189065004G>A	ENST00000332517.3	+	4	888	c.748G>A	c.(748-750)Gcc>Acc	p.A250T	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	250					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGTGAGAGGAGCCCTGGAAAG	0.478000													69	193					0	0	1	0	0
WBSCR16	81554	broad.mit.edu	37	7	74470049	74470049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:74470049G>A	ENST00000503250.2	-	9	1259	c.1190C>T	c.(1189-1191)tCc>tTc	p.S397F	WBSCR16_ENST00000329959.4_Missense_Mutation_p.S397F			Q96I51	WBS16_HUMAN	Williams-Beuren syndrome chromosome region 16	397										kidney(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						TCGGATGCGGGAAACCTGGAT	0.537000													26	67					0	0	1	0	0
ARGFX	503582	broad.mit.edu	37	3	121304974	121304974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121304974C>T	ENST00000334384.3	+	4	485	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	159						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		GCCCACCTCCCCCAGAACATC	0.493000													52	85					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248486965	248486965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248486965C>T	ENST00000317965.2	-	1	934	c.906G>A	c.(904-906)atG>atA	p.M302I		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M302I(1)		breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTAAGATTTTCATTAATGCTC	0.403000													25	60					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	184003362	184003362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184003362C>T	ENST00000402825.3	+	10	1599	c.1599C>T	c.(1597-1599)acC>acT	p.T533T	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000357474.5_Silent_p.T461T|ECE2_ENST00000404464.3_Silent_p.T415T|ECE2_ENST00000359140.4_Silent_p.T386T	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	533	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCTGGAGACCCTCTATGGCA	0.512000													10	79					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10906962	10906962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10906962C>T	ENST00000298232.7	-	23	1912	c.1545G>A	c.(1543-1545)gtG>gtA	p.V515V	TPTE_ENST00000361285.4_Silent_p.V533V|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.V495V	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	533	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAAGTATCTCCACGGCAAAAT	0.353000													7	82					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104075163	104075163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104075163C>T	ENST00000374874.3	+	6	1159	c.720C>T	c.(718-720)ttC>ttT	p.F240F	LPPR1_ENST00000395056.2_Silent_p.F240F	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		240						integral to membrane	catalytic activity										GCACAGCCTTCCTGACAGGCC	0.547000													28	111					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106431506	106431506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106431506G>A	ENST00000407775.2	+	2	425	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	ZFPM2_ENST00000520492.1_5'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	59					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAGCTGCGAAGAAGTGGAATA	0.358000													24	90					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38813452	38813452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38813452G>A	ENST00000359357.3	+	34	4551	c.4297G>A	c.(4297-4299)Gga>Aga	p.G1433R	DNAH8_ENST00000449981.2_Missense_Mutation_p.G1650R|DNAH8_ENST00000441566.1_Missense_Mutation_p.G1433R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGCATTTAAGGGAAAAGGAGA	0.418000													17	126					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7289621	7289621	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7289621C>T	ENST00000537408.1	+	6	1699	c.1161C>T	c.(1159-1161)acC>acT	p.T387T	CLSTN3_ENST00000266546.6_Silent_p.T375T			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	375					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						ACCACTTCACCCTGTCCTTCT	0.587000													28	47					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9197355	9197355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:9197355G>A	ENST00000382496.5	-	10	1658	c.993C>T	c.(991-993)ttC>ttT	p.F331F		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	331	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						AGGGCCCAGAGAAGGCCTGCG	0.602000													41	92					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126208158	126208158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126208158C>T	ENST00000290868.2	-	17	1722	c.1669G>A	c.(1669-1671)Gag>Aag	p.E557K	UROC1_ENST00000383579.3_Missense_Mutation_p.E617K	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	557					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		TTGGAGGTCTCCCTAAAGGGG	0.498000													38	142					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72462204	72462204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72462204C>T	ENST00000309731.7	-	2	131	c.118G>A	c.(118-120)Gag>Aag	p.E40K		NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	40						integral to membrane				cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						TCCGGGGGCTCCTCAACTCTG	0.507000													91	91					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113833	94113833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94113833G>A	ENST00000243673.2	-	4	925	c.754C>T	c.(754-756)Ctc>Ttc	p.L252F	GPR83_ENST00000539203.2_Missense_Mutation_p.L210F	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	252						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATGATGAGGAGGGGCAGGATG	0.567000													13	39					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43433789	43433789	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43433789C>T	ENST00000446844.3	-	0	603				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCTGGAGTCTCAGGATCACAG	0.527000													119	295					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131671830	131671830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:131671830C>T	ENST00000368648.3	-	8	739	c.667G>A	c.(667-669)Ggc>Agc	p.G223S	EBF3_ENST00000355311.5_Missense_Mutation_p.G223S	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	223					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AGCACGTGGCCGTCCACGTTG	0.527000													12	36					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10914373	10914373	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10914373C>T	ENST00000298232.7	-	20	1659	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E	TPTE_ENST00000361285.4_Missense_Mutation_p.G449E|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.G411E	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	449	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CGAACATTTTCCTAATGAAAT	0.318000													6	55					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33589863	33589863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33589863G>A	ENST00000262873.7	+	42	6007	c.5915G>A	c.(5914-5916)cGg>cAg	p.R1972Q		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1930						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CTGCGGGCACGGACCCGGGAC	0.647000											OREG0025884	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	41					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77406945	77406945	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77406945G>A	ENST00000560626.2	-	7	5269	c.4794C>T	c.(4792-4794)ctC>ctT	p.L1598L	PEAK1_ENST00000312493.4_Silent_p.L1598L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1598	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TCTCATAGATGAGGATGCCTG	0.542000													32	87					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104440363	104440363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:104440363G>A	ENST00000372582.1	+	3	1045	c.289G>A	c.(289-291)Gag>Aag	p.E97K	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E97K	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	97	Ig-like C2-type 1.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GATGAGCAAAGAGGAAGATTC	0.448000													35	24					0	0	1	0	0
GLYATL2	219970	broad.mit.edu	37	11	58604639	58604639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58604639C>T	ENST00000287275.1	-	5	715	c.325G>A	c.(325-327)Ggc>Agc	p.G109S	GLYATL2_ENST00000532258.1_Missense_Mutation_p.G109S|GLYATL2_ENST00000533636.1_5'UTR	NM_145016.3	NP_659453.3	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	109						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TCATCCAAGCCCTCTTGGCAA	0.393000													51	131					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66944318	66944318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66944318G>A	ENST00000299752.4	-	15	2205	c.2012C>T	c.(2011-2013)cCc>cTc	p.P671L	CDH16_ENST00000570262.1_Missense_Mutation_p.P591L|CDH16_ENST00000568632.1_Missense_Mutation_p.P574L|CDH16_ENST00000394055.3_Missense_Mutation_p.P649L|CDH16_ENST00000565796.1_Intron	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	671	Ectodomain G.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTATTGGGAGGGCACAGGGGC	0.632000													28	81					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	40998146	40998146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40998146C>T	ENST00000253799.3	+	1	1530	c.1503C>T	c.(1501-1503)ctC>ctT	p.L501L	AOC2_ENST00000452774.2_Silent_p.L501L	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	501					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		AGGAGGGCCTCCTCTTTGGGA	0.567000													32	56					0	0	1	0	0
CEP63	80254	broad.mit.edu	37	3	134256003	134256003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134256003C>T	ENST00000337090.3	+	6	621	c.448C>T	c.(448-450)Cgt>Tgt	p.R150C	CEP63_ENST00000513612.2_Missense_Mutation_p.R150C|CEP63_ENST00000606977.1_Missense_Mutation_p.R150C|CEP63_ENST00000383229.3_Missense_Mutation_p.R150C|CEP63_ENST00000354446.3_Missense_Mutation_p.R150C|CEP63_ENST00000332047.5_Missense_Mutation_p.R150C			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	150					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TCAGGAATTCCGTCAGAAATC	0.458000													19	84					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127648455	127648455	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127648455C>T	ENST00000508053.1	-	43	5724	c.4750G>A	c.(4750-4752)Gga>Aga	p.G1584R	FBN2_ENST00000262464.4_Missense_Mutation_p.G1584R			P35556	FBN2_HUMAN	fibrillin 2	1584	TB 6.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCTCGAGGTCCAAACTTCAGG	0.537000													30	326					0	0	1	0	0
HSPB8	26353	broad.mit.edu	37	12	119631578	119631578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119631578C>T	ENST00000281938.2	+	3	1177	c.506C>T	c.(505-507)cCc>cTc	p.P169L	HSPB8_ENST00000542496.1_3'UTR	NM_014365.2	NP_055180.1	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	169					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	14	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ATCGAAGCTCCCCAGGTCCCT	0.517000													36	81					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45923856	45923856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45923856G>A	ENST00000348697.2	+	4	598	c.451G>A	c.(451-453)Gga>Aga	p.G151R	FBLN1_ENST00000340923.5_Missense_Mutation_p.G151R|FBLN1_ENST00000402984.3_Missense_Mutation_p.G189R|FBLN1_ENST00000442170.2_Missense_Mutation_p.G151R|FBLN1_ENST00000327858.6_Missense_Mutation_p.G151R|FBLN1_ENST00000262722.7_Missense_Mutation_p.G151R			P23142	FBLN1_HUMAN	fibulin 1	151					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCAGGAGACCGGAGATTTGGA	0.572000													22	87					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031883	32031883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:32031883C>T	ENST00000360311.4	+	2	1861	c.1312C>T	c.(1312-1314)Cgt>Tgt	p.R438C		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						TTTTAGACGTCGTTCATATCT	0.378000													18	68					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23619259	23619259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23619259G>A	ENST00000261584.4	-	12	3428	c.3276C>T	c.(3274-3276)ctC>ctT	p.L1092L	CTD-2196E14.3_ENST00000561764.1_RNA	NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	1092	Interaction with RAD51 and BRCA2.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		TAATCACAATGAGCTGAAACA	0.483000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					14	56					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114120263	114120263	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114120263C>T	ENST00000357077.4	+	4	435	c.382C>T	c.(382-384)Cag>Tag	p.Q128*	ANK2_ENST00000264366.6_Nonsense_Mutation_p.Q128*|ANK2_ENST00000506722.1_Nonsense_Mutation_p.Q107*|ANK2_ENST00000394537.3_Nonsense_Mutation_p.Q128*	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	128					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGCACAGTCTCAGGTATTCCA	0.358000													19	52					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711531	192711531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:192711531C>T	ENST00000304141.4	-	1	450	c.121G>A	c.(121-123)Ggg>Agg	p.G41R	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	41						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCTGTGTTCCCTAGGTTCAGG	0.612000													19	76					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129909563	129909563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129909563C>T	ENST00000222481.4	+	3	263	c.208C>T	c.(208-210)Ccc>Tcc	p.P70S		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	70					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					CGTCCGAGTTCCCTTCGTCAA	0.498000													17	98					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206480313	206480313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206480313C>T	ENST00000406610.2	+	23	3601	c.3394C>T	c.(3394-3396)Ctc>Ttc	p.L1132F	PARD3B_ENST00000488622.1_3'UTR|PARD3B_ENST00000349953.3_Missense_Mutation_p.L1031F|PARD3B_ENST00000351153.1_Missense_Mutation_p.L1063F|PARD3B_ENST00000358768.2_Missense_Mutation_p.L1070F	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	1132					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CCCCACAGAGCTCAGGGTGGC	0.617000													30	106					0	0	1	0	0
NLGN1	22871	broad.mit.edu	37	3	173322869	173322869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:173322869C>T	ENST00000457714.1	+	3	910	c.481C>T	c.(481-483)Ccg>Tcg	p.P161S	NLGN1_ENST00000545397.1_Missense_Mutation_p.P161S|NLGN1_ENST00000401917.3_Missense_Mutation_p.P161S|NLGN1_ENST00000361589.4_Missense_Mutation_p.P161S	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	161					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity	p.P161T(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TATATATGTCCCGACTGAGGA	0.338000													8	127					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138400170	138400170	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:138400170G>A	ENST00000409968.1	+	21	4090	c.3912G>A	c.(3910-3912)tgG>tgA	p.W1304*	THSD7B_ENST00000272643.3_Nonsense_Mutation_p.W1307*|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Nonsense_Mutation_p.W1276*					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCTACAGCTGGGTCCTTGGCA	0.488000													33	76					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454751	84454751	+	Missense_Mutation	SNP	G	G	A	rs146746846		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:84454751G>A	ENST00000377084.2	-	1	1777	c.892C>T	c.(892-894)Cat>Tat	p.H298Y		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	298						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GGTGTGGCATGATCCTCTTGC	0.562000													16	47					0	0	1	0	0
TACR1	6869	broad.mit.edu	37	2	75347872	75347872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:75347872G>A	ENST00000305249.4	-	2	1177	c.412C>T	c.(412-414)Ctc>Ttc	p.L138F	TACR1_ENST00000497764.1_5'UTR|TACR1_ENST00000409848.3_Missense_Mutation_p.L138F	NM_001058.3	NP_001049.1	P25103	NK1R_HUMAN	tachykinin receptor 1	138					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(8)|ovary(1)|skin(1)	24					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	CGGGGCTGGAGGGGATGTATG	0.517000													17	45					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27390186	27390186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:27390186G>A	ENST00000379214.4	-	18	2527	c.2084C>T	c.(2083-2085)cCa>cTa	p.P695L	LGR4_ENST00000389858.4_Missense_Mutation_p.P671L	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	695						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						TGTAGGAAATGGCAAACAAAG	0.428000													20	84					0	0	1	0	0
CLEC10A	10462	broad.mit.edu	37	17	6979059	6979059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6979059C>T	ENST00000576617.1	-	7	854	c.585G>A	c.(583-585)agG>agA	p.R195R	CLEC10A_ENST00000571664.1_Silent_p.R198R|CLEC10A_ENST00000254868.4_Silent_p.R222R|CLEC10A_ENST00000416562.2_Silent_p.R195R			Q8IUN9	CLC10_HUMAN	C-type lectin domain family 10, member A	222	C-type lectin.				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						CCTGCTCCTCCCTGGAGTTGA	0.537000													28	37					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1437209	1437209	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1437209G>A	ENST00000345913.4	+	4	270		c.e4-1		TPO_ENST00000382269.3_Splice_Site|TPO_ENST00000349624.3_Splice_Site|TPO_ENST00000329066.4_Splice_Site|TPO_ENST00000337415.3_Splice_Site|TPO_ENST00000539820.1_Splice_Site|TPO_ENST00000497517.2_Intron|TPO_ENST00000346956.3_Splice_Site|TPO_ENST00000382198.1_Splice_Site|TPO_ENST00000382201.3_Splice_Site	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase						cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ATGTGCCATAGAAACCTCAAG	0.363000													10	79					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690487	33690487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33690487G>A	ENST00000394566.1	-	4	612	c.340C>T	c.(340-342)Cct>Tct	p.P114S	SLFN11_ENST00000308377.4_Missense_Mutation_p.P114S	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	114						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCAGGGAAAGGGCCACTGCTC	0.458000													11	56					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583862	88583862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88583862G>A	ENST00000339673.6	+	6	1031	c.932G>A	c.(931-933)aGa>aAa	p.R311K	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.R295K|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	311					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CAACCCAGGAGAGACAGCAAG	0.517000													8	76					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24918476	24918476	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24918476G>A	ENST00000347898.3	+	12	1867	c.1245G>A	c.(1243-1245)aaG>aaA	p.K415K	SLC5A11_ENST00000449109.2_Silent_p.K259K|SLC5A11_ENST00000565769.1_Silent_p.K351K|SLC5A11_ENST00000545376.1_Silent_p.K345K|SLC5A11_ENST00000539472.1_Silent_p.K351K|SLC5A11_ENST00000568579.1_Silent_p.K345K|SLC5A11_ENST00000569071.1_Silent_p.K259K|SLC5A11_ENST00000424767.2_Silent_p.K380K|SLC5A11_ENST00000567758.1_Silent_p.K380K	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	415					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		CATCTGAGAAGGAGCTCATGA	0.602000													25	125					0	0	1	0	0
SLC22A17	51310	broad.mit.edu	37	14	23817804	23817804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23817804G>A	ENST00000354772.3	-	5	1106	c.603C>T	c.(601-603)ttC>ttT	p.F201F	SLC22A17_ENST00000474057.1_Intron|SLC22A17_ENST00000397267.1_Silent_p.F201F|SLC22A17_ENST00000206544.8_Silent_p.F201F|SLC22A17_ENST00000397260.3_Silent_p.F90F	NM_016609.3	NP_057693.3	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17	201					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CCAGGAACAGGAAGTGCCCTC	0.597000													30	124					0	0	1	0	0
AOC1	26	broad.mit.edu	37	7	150554705	150554705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150554705C>T	ENST00000493429.1	+	4	1731	c.1147C>T	c.(1147-1149)Cat>Tat	p.H383Y	AOC1_ENST00000416793.2_Missense_Mutation_p.H383Y|AOC1_ENST00000467291.1_Missense_Mutation_p.H383Y|AOC1_ENST00000360937.4_Missense_Mutation_p.H383Y					amine oxidase, copper containing 1																		CAGCGTCACTCATGAGTTAGC	0.617000													36	112					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32525063	32525063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32525063C>T	ENST00000286827.3	-	20	3728	c.3257G>A	c.(3256-3258)gGa>gAa	p.G1086E	TIAM1_ENST00000541036.1_Missense_Mutation_p.G1026E	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1086	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CGTTAAATTTCCAAAAAGCAC	0.333000													15	46					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73964163	73964163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73964163G>A	ENST00000373468.1	-	3	880	c.229C>T	c.(229-231)Ccg>Tcg	p.P77S	KIAA2022_ENST00000055682.5_Missense_Mutation_p.P77S			Q5QGS0	K2022_HUMAN	KIAA2022	77					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GGAGAGGGCGGGCTCTGCATA	0.537000													31	21					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43038186	43038186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43038186G>A	ENST00000267890.6	-	15	3650	c.3542C>T	c.(3541-3543)tCg>tTg	p.S1181L		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1181	Ser-rich.				cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		ATGTGGGGACGAACTCCTCTG	0.592000													26	69					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46306722	46306722	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46306722G>A	ENST00000357422.2	+	4	616	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	CCR3_ENST00000541018.1_Missense_Mutation_p.E25K|CCR3_ENST00000395940.2_Missense_Mutation_p.E25K|CCR3_ENST00000545097.1_Missense_Mutation_p.E46K|CCR3_ENST00000395942.2_Missense_Mutation_p.E25K			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	25					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CCTGCTCTGTGAAAAAGCTGA	0.502000													17	41					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301398	11301398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11301398G>A	ENST00000397056.1	+	3	866	c.675G>A	c.(673-675)gaG>gaA	p.E225E	HRH1_ENST00000431010.2_Silent_p.E225E|HRH1_ENST00000438284.2_Silent_p.E225E	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	225					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	AGCACCGGGAGCTCATCAATA	0.542000													32	71					0	0	1	0	0
MCOLN2	255231	broad.mit.edu	37	1	85397184	85397184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85397184G>A	ENST00000370608.3	-	12	1470	c.1403C>T	c.(1402-1404)aCc>aTc	p.T468I	MCOLN2_ENST00000284027.5_Missense_Mutation_p.T440I	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	468						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		TTGGGCAAAGGTTGCAAACAT	0.388000													6	107					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25701497	25701497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25701497G>A	ENST00000377961.2	+	11	933	c.765G>A	c.(763-765)gtG>gtA	p.V255V	SCGN_ENST00000334979.6_3'UTR	NM_006998.3	NP_008929.2	O76038	SEGN_HUMAN	secretagogin, EF-hand calcium binding protein	255	EF-hand 6.					extracellular region|transport vesicle membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						ACTGCGACGTGAACAAGGATG	0.488000													27	94					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90897934	90897934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90897934C>T	ENST00000354377.3	+	2	228	c.42C>T	c.(40-42)caC>caT	p.H14H	ZNF774_ENST00000379090.5_Silent_p.H14H|ZNF774_ENST00000558115.1_Intron	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	14	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TACCTGGACACTGCTTAGAGA	0.458000													8	26					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169388371	169388371	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169388371C>T	ENST00000545005.1	-	5	1602	c.1095G>A	c.(1093-1095)gaG>gaA	p.E365E	CCDC181_ENST00000367806.3_Silent_p.E365E|CCDC181_ENST00000367805.3_Silent_p.E365E|CCDC181_ENST00000491570.1_5'UTR					coiled-coil domain containing 181																		TTTTTTCTTTCTCTTCTTCTA	0.323000													5	58					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7572486	7572486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:7572486G>A	ENST00000399429.3	-	2	161	c.21C>T	c.(19-21)gtC>gtT	p.V7V		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	7					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGAGATAGAAGACAAAATATC	0.348000													46	94					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39112006	39112006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39112006G>A	ENST00000379907.4	+	18	2103	c.1976G>A	c.(1975-1977)gGa>gAa	p.G659E	ADAM32_ENST00000437682.2_Missense_Mutation_p.G560E|ADAM32_ENST00000519315.1_Missense_Mutation_p.G553E	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	659					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.G658V(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CGTTCCAAAGGATTTTCCATA	0.343000													7	9					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5841957	5841957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5841957C>T	ENST00000317037.2	+	1	414	c.392C>T	c.(391-393)cCc>cTc	p.P131L	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCTGCTACCCCTTACGCTAT	0.552000													21	87					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70007780	70007780	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70007780C>T	ENST00000355303.5	+	18	2138	c.1833C>T	c.(1831-1833)ttC>ttT	p.F611F	ANO1_ENST00000538023.1_Silent_p.F611F|ANO1_ENST00000531349.1_Silent_p.F320F|ANO1_ENST00000316296.5_Silent_p.F553F|ANO1_ENST00000398543.2_Silent_p.F465F|ANO1_ENST00000530676.1_Silent_p.F465F	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	611					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TCAAGGCTTTCCTGCTGAAGT	0.537000													25	142					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126219633	126219633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126219633G>A	ENST00000290868.2	-	11	1103	c.1050C>T	c.(1048-1050)ttC>ttT	p.F350F	UROC1_ENST00000383579.3_Silent_p.F410F	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	350					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		AGCCGCCATTGAACGGGTTGT	0.617000													37	79					0	0	1	0	0
OR51F1	256892	broad.mit.edu	37	11	4790452	4790452	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4790452G>A	ENST00000380383.1	-	1	716	c.717C>T	c.(715-717)tcC>tcT	p.S239S	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron|OR51F1_ENST00000343430.3_Silent_p.S232S			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	232						integral to membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		ATTCTTCAGGGGAGGCAATTC	0.458000													54	108					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25284986	25284986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25284986C>T	ENST00000218548.6	+	21	3305	c.2972C>T	c.(2971-2973)tCc>tTc	p.S991F	ATP12A_ENST00000381946.3_Missense_Mutation_p.S985F	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	985					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CTGATCCTCTCCTATGGCCTC	0.498000													26	41					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20915648	20915648	+	Missense_Mutation	SNP	C	C	T	rs140821931		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20915648C>T	ENST00000375071.3	+	1	208	c.26C>T	c.(25-27)aCc>aTc	p.T9I	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	9					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	CCTGCCTGCACCCTGAAGCCT	0.657000													13	74					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17029467	17029467	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17029467C>T	ENST00000492551.1	-	0	898					NR_026567.1																						GCTGGAAAGCCCTGGGGAGGC	0.577000													6	36					0	0	1	0	0
EEF1A2	1917	broad.mit.edu	37	20	62126344	62126344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62126344C>T	ENST00000217182.3	-	4	600	c.435G>A	c.(433-435)gtG>gtA	p.V145V	EEF1A2_ENST00000298049.7_Silent_p.V145V	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	145						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			TGAGCTGCTTCACACCCAGCG	0.622000													31	93					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205896725	205896725	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205896725G>A	ENST00000367135.3	-	10	1223	c.1110C>T	c.(1108-1110)atC>atT	p.I370I	SLC26A9_ENST00000367134.2_Silent_p.I370I|SLC26A9_ENST00000340781.4_Silent_p.I370I	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	370						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGCCGAGAGCGATCATCTCCT	0.552000													10	30					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118969873	118969873	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:118969873G>A	ENST00000515256.1	+	3	602	c.430G>A	c.(430-432)Gag>Aag	p.E144K				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	144						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						TGTCTCCTGGGAGACAGAGGA	0.468000													35	67					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161753803	161753803	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161753803C>T	ENST00000367942.3	+	4	338	c.271C>T	c.(271-273)Cag>Tag	p.Q91*		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	91	Transcription activation.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GGCAGAACCTCAGCCACTTTC	0.398000													42	164					0	0	1	0	0
ZNF596	169270	broad.mit.edu	37	8	192971	192971	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:192971C>T	ENST00000398612.1	+	3	480	c.97C>T	c.(97-99)Caa>Taa	p.Q33*	ZNF596_ENST00000522866.1_3'UTR|ZNF596_ENST00000308811.4_Nonsense_Mutation_p.Q33*|ZNF596_ENST00000320552.2_Nonsense_Mutation_p.Q33*	NM_001042415.1|NM_001042416.1	NP_001035880.1|NP_001035881.1	Q8TC21	ZN596_HUMAN	zinc finger protein 596	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(5)	14		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		AAAGCTGTTTCAAGATGTGAT	0.393000													31	46					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39050237	39050237	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:39050237G>T	ENST00000295373.6	-	17	3315	c.3189C>A	c.(3187-3189)ccC>ccA	p.P1063P		NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1063							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TCACATCCACGGGCAGAGAGG	0.463000													24	76					1.10923e-09	1.11355e-09	1	1	0
DDX31	64794	broad.mit.edu	37	9	135487526	135487526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135487526G>A	ENST00000372159.3	-	19	2408	c.2257C>T	c.(2257-2259)Ccc>Tcc	p.P753S	DDX31_ENST00000372153.1_Missense_Mutation_p.P680S|DDX31_ENST00000438527.3_Missense_Mutation_p.P624S	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	753						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		AGATTCCTGGGGGCATCTCTT	0.552000													32	131					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12316366	12316366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12316366C>T	ENST00000256186.2	+	3	1679	c.1388C>T	c.(1387-1389)cCt>cTt	p.P463L		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	463	Poly-Pro.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcctcctcctcctcctcct	0.577000													13	14					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212149950	212149950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:212149950G>A	ENST00000366994.3	-	12	1686	c.1582C>T	c.(1582-1584)Cgt>Tgt	p.R528C	INTS7_ENST00000366993.3_Missense_Mutation_p.R528C|INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000366992.3_Missense_Mutation_p.R528C|INTS7_ENST00000440600.2_Missense_Mutation_p.R479C	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	528					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CTGGCAATACGGTATACAGTC	0.408000													43	91					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57931689	57931689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57931689C>T	ENST00000574161.1	+	10	1184	c.1065C>T	c.(1063-1065)caC>caT	p.H355H	GCOM1_ENST00000396180.1_Silent_p.H324H|GCOM1_ENST00000380560.2_Silent_p.H286H|GCOM1_ENST00000380561.2_Silent_p.H324H|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Silent_p.H355H|GCOM1_ENST00000572390.1_Silent_p.H355H|MYZAP_ENST00000267853.5_Silent_p.H355H|GCOM1_ENST00000587652.1_Silent_p.H355H|MYZAP_ENST00000380565.4_Silent_p.H355H|GCOM1_ENST00000380568.3_Silent_p.H355H	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		355					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GGATCAGACACCTAGATGACA	0.498000													8	47					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54570741	54570741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54570741G>A	ENST00000251636.5	-	15	2673	c.2525C>T	c.(2524-2526)cCt>cTt	p.P842L	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	842							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GATTTTATGAGGATTCATGTA	0.358000													54	154					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042300	74042300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74042300G>A	ENST00000409561.1	+	3	1071	c.950G>A	c.(949-951)aGc>aAc	p.S317N		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	317										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TCCTTCAGTAGCAGAAATACC	0.468000													17	53					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169145710	169145710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169145710G>A	ENST00000256935.8	+	22	2262	c.2182G>A	c.(2182-2184)Gag>Aag	p.E728K	DOCK2_ENST00000520908.1_Missense_Mutation_p.E220K|DOCK2_ENST00000540750.1_5'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	728					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGCAGAGGGGAGCAATGTGA	0.383000													31	60					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95347184	95347184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95347184C>T	ENST00000371483.4	+	4	1008	c.952C>T	c.(952-954)Ctc>Ttc	p.L318F	FFAR4_ENST00000604414.1_Intron|FFAR4_ENST00000371481.4_Missense_Mutation_p.L302F	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		CTGGCCGTCCCTCTTCTTCTG	0.488000													60	255					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76395507	76395507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76395507G>A	ENST00000357063.3	+	15	3818	c.2558G>A	c.(2557-2559)aGa>aAa	p.R853K	LMO7_ENST00000341547.4_Missense_Mutation_p.R519K|LMO7_ENST00000377534.3_Missense_Mutation_p.R853K|LMO7_ENST00000321797.8_Missense_Mutation_p.R568K|LMO7_ENST00000465261.2_Missense_Mutation_p.R568K|LMO7_ENST00000526202.1_Missense_Mutation_p.R418K			Q8WWI1	LMO7_HUMAN	LIM domain 7	853						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TTTGCAAAAAGAGAGGACCGT	0.443000													36	90					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102441875	102441875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102441875C>T	ENST00000413150.2	+	5	456	c.401C>T	c.(400-402)tCc>tTc	p.S134F	MAP4K4_ENST00000350878.4_Missense_Mutation_p.S114F|MAP4K4_ENST00000324219.4_Missense_Mutation_p.S134F|MAP4K4_ENST00000425019.1_Missense_Mutation_p.S134F|MAP4K4_ENST00000456652.1_Missense_Mutation_p.S134F|MAP4K4_ENST00000347699.4_Missense_Mutation_p.S134F|MAP4K4_ENST00000302217.5_Missense_Mutation_p.S134F|MAP4K4_ENST00000350198.4_Missense_Mutation_p.S134F	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	134	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GCTTACATCTCCAGAGAAATC	0.478000													9	34					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238249231	238249231	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238249231C>T	ENST00000295550.4	-	38	8780	c.8328G>A	c.(8326-8328)agG>agA	p.R2776R	COL6A3_ENST00000409809.1_Silent_p.R2570R|COL6A3_ENST00000472056.1_Silent_p.R2169R|COL6A3_ENST00000346358.4_Silent_p.R2576R|COL6A3_ENST00000353578.4_Silent_p.R2570R|COL6A3_ENST00000347401.3_Silent_p.R2575R	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2776	Nonhelical region.|VWFA 12.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGTTCACCTTCCTGCCAATGC	0.562000													34	77					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47401285	47401285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47401285G>A	ENST00000310638.4	-	5	576	c.545C>T	c.(544-546)cCt>cTt	p.P182L	CYP4A11_ENST00000371904.4_Missense_Mutation_p.P182L|CYP4A11_ENST00000457840.2_Missense_Mutation_p.P78L|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371905.1_Missense_Mutation_p.P182L	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	182					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	GACCTCCAGAGGGGAATCCTG	0.542000													12	59					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33624341	33624341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33624341C>T	ENST00000504830.1	-	14	2473	c.2138G>A	c.(2137-2139)gGa>gAa	p.G713E	ADAMTS12_ENST00000352040.3_Intron|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	713	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						ATTACCAGATCCTTCCTTCTG	0.443000										HNSCC(64;0.19)			34	115					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151671950	151671950	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:151671950G>A	ENST00000402676.2	+	4	2664	c.2424G>A	c.(2422-2424)aaG>aaA	p.K808K	AKAP12_ENST00000253332.1_Silent_p.K808K|AKAP12_ENST00000354675.6_Silent_p.K710K|AKAP12_ENST00000359755.5_Silent_p.K703K	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	808	AKAP 3.				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TCTCAATCAAGAAGTTTATTC	0.498000													37	68					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29346369	29346369	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:29346369G>C	ENST00000558402.1	+	5	881	c.282G>C	c.(280-282)gaG>gaC	p.E94D	APBA2_ENST00000558259.1_Missense_Mutation_p.E94D|APBA2_ENST00000561069.1_Missense_Mutation_p.E94D|APBA2_ENST00000411764.1_Missense_Mutation_p.E94D|APBA2_ENST00000558330.1_Missense_Mutation_p.E94D			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	94	Poly-Glu.				nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CTGAGGAGGAGGAGGGCATCA	0.607000													24	124					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21215530	21215530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21215530G>A	ENST00000574002.1	-	10	1275	c.793C>T	c.(793-795)Cct>Tct	p.P265S	ZP2_ENST00000219593.4_Missense_Mutation_p.P265S|AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Missense_Mutation_p.P265S			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	265					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		CAGGTCACAGGATCTAGAAGG	0.468000													21	75					0	0	1	0	0
AZGP1P1	646282	broad.mit.edu	37	7	99580912	99580912	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99580912G>A	ENST00000425474.1	+	0	233					NR_036679.1																						TGGGACCATGGAGACATGCGG	0.542000													15	24					0	0	1	0	0
GJA9	81025	broad.mit.edu	37	1	39341152	39341152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:39341152C>T	ENST00000454994.2	-	2	895	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	GJA9_ENST00000360786.3_Missense_Mutation_p.E207K|MYCBP_ENST00000489803.1_5'UTR|GJA9_ENST00000357771.3_Missense_Mutation_p.E207K|RP5-864K19.4_ENST00000456813.1_RNA|RP5-864K19.4_ENST00000433671.2_RNA|RP5-864K19.4_ENST00000443161.1_RNA			P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	207					cell communication	connexon complex|integral to membrane				breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			ATTGTCTTTTCTGTTGGTCTT	0.338000													29	57					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128186115	128186115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128186115G>A	ENST00000453608.2	+	8	1152	c.1144G>A	c.(1144-1146)Gag>Aag	p.E382K	PROC_ENST00000422777.3_Missense_Mutation_p.E327K|PROC_ENST00000234071.3_Missense_Mutation_p.E327K|PROC_ENST00000409048.1_Missense_Mutation_p.E361K			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	327	Peptidase S1.				blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	CGGCCTTGCAGAGCGCGAGCT	0.657000													45	136					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62658388	62658388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62658388C>T	ENST00000535781.1	+	15	2073	c.1962C>T	c.(1960-1962)gcC>gcT	p.A654A	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	694					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TCAGGGCAGCCCAAGATCTGT	0.572000													27	51					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719138	140719138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140719138G>A	ENST00000394576.2	+	1	600	c.600G>A	c.(598-600)ctG>ctA	p.L200L	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGCTCTCTGGACCGCGAGG	0.587000													29	61					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27465619	27465619	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27465619C>T	ENST00000264705.4	+	41	6516	c.6354C>T	c.(6352-6354)ttC>ttT	p.F2118F	CAD_ENST00000403525.1_Silent_p.F2055F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	2118	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TGCGGGCCTTCGTGGCCTCCC	0.657000													24	45					0	0	1	0	0
NSMF	26012	broad.mit.edu	37	9	140344095	140344095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140344095G>A	ENST00000371475.3	-	15	1682	c.1451C>T	c.(1450-1452)cCt>cTt	p.P484L	NSMF_ENST00000265663.7_Missense_Mutation_p.P482L|NSMF_ENST00000339554.3_Missense_Mutation_p.P281L|NSMF_ENST00000371473.3_Missense_Mutation_p.P454L|NSMF_ENST00000484316.1_5'UTR|NSMF_ENST00000541195.1_Missense_Mutation_p.P281L|NSMF_ENST00000392812.4_Missense_Mutation_p.P461L|NSMF_ENST00000371472.2_Missense_Mutation_p.P482L|NSMF_ENST00000371482.1_Missense_Mutation_p.P148L|NSMF_ENST00000371474.3_Missense_Mutation_p.P459L|NSMF_ENST00000437259.1_Missense_Mutation_p.P461L	NM_001130969.1	NP_001124441.1			NMDA receptor synaptonuclear signaling and neuronal migration factor																		GACCCTATAAGGAGTCATGAG	0.637000													6	13					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76980987	76980987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76980987C>T	ENST00000315938.4	-	7	669	c.419G>A	c.(418-420)aGg>aAg	p.R140K	GDPD4_ENST00000376217.2_Missense_Mutation_p.R140K	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	140					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						ATGTGTCATCCTGTATCTTCT	0.333000													9	31					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41754721	41754721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41754721G>A	ENST00000301178.4	+	14	1897	c.1707G>A	c.(1705-1707)atG>atA	p.M569I	AXL_ENST00000593513.1_Missense_Mutation_p.M301I|AXL_ENST00000359092.3_Missense_Mutation_p.M560I	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	569	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						TGAAGACGATGAAGAGTGAGT	0.547000													15	39					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37731005	37731005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37731005G>A	ENST00000539465.1	+	9	1356	c.763G>A	c.(763-765)Gac>Aac	p.D255N	FRMPD1_ENST00000541302.1_Missense_Mutation_p.D124N|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000536622.1_Missense_Mutation_p.D77N|FRMPD1_ENST00000377765.3_Missense_Mutation_p.D255N			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	255	FERM.					cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GGAGTCACATGACTACCGCTG	0.502000													17	56					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62798036	62798036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:62798036C>T	ENST00000280377.5	+	22	2885	c.2827C>T	c.(2827-2829)Cct>Tct	p.P943S	USP15_ENST00000353364.3_Missense_Mutation_p.P914S|USP15_ENST00000393654.3_Missense_Mutation_p.P918S	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	943					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TGGCTTTTTTCCTCTTGACCG	0.378000													42	171					0	0	1	0	0
BCAR3	8412	broad.mit.edu	37	1	94140254	94140254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94140254G>A	ENST00000370244.1	-	4	521	c.233C>T	c.(232-234)tCc>tTc	p.S78F	BCAR3_ENST00000370243.1_Missense_Mutation_p.S78F|BCAR3_ENST00000260502.6_Missense_Mutation_p.S78F	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	78					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CTGCCGTGGGGATTTGGAGTG	0.552000													10	37					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8234014	8234014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8234014G>A	ENST00000520004.1	-	3	2169	c.1905C>T	c.(1903-1905)tgC>tgT	p.C635C	SGK223_ENST00000330777.4_Silent_p.C635C			Q86YV5	SG223_HUMAN		635							ATP binding|non-membrane spanning protein tyrosine kinase activity										CCTCTATCCGGCACTGACGAC	0.602000													17	53					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89949527	89949527	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89949527G>A	ENST00000405460.2	+	20	4232	c.4136G>A	c.(4135-4137)gGa>gAa	p.G1379E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1379					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GACGGTAATGGAAGCATCTAC	0.408000													4	19					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55953808	55953808	+	Missense_Mutation	SNP	G	G	A	rs11540507		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55953808G>A	ENST00000263923.4	-	27	3923	c.3628C>T	c.(3628-3630)Ccc>Tcc	p.P1210S	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1210					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TGGAATTTGGGGTCACATACT	0.507000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			17	58					0	0	1	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077314	19077314	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:19077314G>A	ENST00000329773.2	-	2	723	c.636C>T	c.(634-636)ggC>ggT	p.G212G		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	212					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						GACCCCTGGAGCCACAGAGGA	0.547000													26	43					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42485934	42485934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42485934G>A	ENST00000545399.1	-	10	1434	c.1281C>T	c.(1279-1281)atC>atT	p.I427I	ATP1A3_ENST00000602133.1_Silent_p.I384I|ATP1A3_ENST00000543770.1_Silent_p.I425I|ATP1A3_ENST00000302102.5_Silent_p.I414I	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	414					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						AGAGCCCAGCGATGTGAGACA	0.622000													20	52					0	0	1	0	0
ACP6	51205	broad.mit.edu	37	1	147122011	147122011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:147122011G>A	ENST00000369238.5	-	8	1359	c.912C>T	c.(910-912)ttC>ttT	p.F304F	ACP6_ENST00000460583.1_5'UTR	NM_016361.3	NP_057445.4	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic	304					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(4)|prostate(1)	16	all_hematologic(923;0.0276)					GGATGTGGAGGAATGGGCCTA	0.522000													23	45					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23397352	23397352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23397352G>A	ENST00000324366.8	-	3	521	c.298C>T	c.(298-300)Cgc>Tgc	p.R100C	PRMT5_ENST00000538452.1_5'UTR|PRMT5_ENST00000397440.4_Missense_Mutation_p.R83C|PRMT5_ENST00000216350.8_Intron|PRMT5_ENST00000397441.2_Missense_Mutation_p.R83C|PRMT5_ENST00000553641.1_5'UTR|PRMT5_ENST00000553897.1_Intron	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	100					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GAGTTCCTGCGAATCTTCTCC	0.498000													7	102					0	0	1	0	0
PPCS	79717	broad.mit.edu	37	1	42925347	42925347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42925347C>T	ENST00000372561.3	+	3	693	c.686C>T	c.(685-687)tCc>tTc	p.S229F	PPCS_ENST00000372562.1_Missense_Mutation_p.S56F|PPCS_ENST00000472013.1_3'UTR|PPCS_ENST00000455780.1_Missense_Mutation_p.S56F|PPCS_ENST00000372556.3_3'UTR	NM_024664.2	NP_078940.2	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase	229					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|skin(3)	12	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TTTATAATTTCCTTTAAGTTG	0.388000													11	125					0	0	1	0	0
C10orf62	414157	broad.mit.edu	37	10	99350007	99350007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99350007C>T	ENST00000370640.3	+	1	558	c.353C>T	c.(352-354)tCc>tTc	p.S118F	HOGA1_ENST00000370647.4_Intron|HOGA1_ENST00000370646.4_Intron|PI4K2A_ENST00000555577.1_Intron|PI4K2A_ENST00000370649.3_Intron	NM_001009997.2	NP_001009997.2	Q5T681	CJ062_HUMAN	chromosome 10 open reading frame 62	118							protein binding			endometrium(2)|kidney(1)|lung(1)	4		Colorectal(252;0.162)		Epithelial(162;9.58e-11)|all cancers(201;8.62e-09)		AAAGCCCCATCCACTGATGAG	0.627000													26	48					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106066431	106066431	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106066431C>T	ENST00000577108.1	-	0	115				IGHE_ENST00000576077.1_RNA																							AGACACCGCTCGCTGGACGGT	0.607000													43	128					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713226	70713226	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70713226C>T	ENST00000530196.1	-	0	1292					NR_003951.1																						AGGTGGTCTTCATAAAATCAG	0.413000													60	145					0	0	1	0	0
CHRNA3	1136	broad.mit.edu	37	15	78911186	78911186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78911186G>A	ENST00000326828.5	-	2	538	c.154C>T	c.(154-156)Cct>Tct	p.P52S	CHRNA3_ENST00000348639.3_Missense_Mutation_p.P52S	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	52					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TTGGCTACAGGCCGGATGATC	0.572000											OREG0023334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	109					0	0	1	0	0
PAFAH1B2	5049	broad.mit.edu	37	11	117038270	117038270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117038270C>T	ENST00000527958.1	+	6	704	c.545C>T	c.(544-546)tCg>tTg	p.S182L	PAFAH1B2_ENST00000419197.2_Intron|PAFAH1B2_ENST00000526888.1_Intron|PAFAH1B2_ENST00000530272.1_Intron|PAFAH1B2_ENST00000529887.2_Intron	NM_002572.3	NP_002563.1	P68402	PA1B2_HUMAN	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	182					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity			kidney(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;1.68e-05)|Epithelial(105;0.000162)|all cancers(92;0.00111)		TTTGTGCACTCGGACGGTGCC	0.537000			T	IGH@	MLCLS								8	55					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196964899	196964899	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196964899G>A	ENST00000367414.5	+	5	788	c.732G>A	c.(730-732)aaG>aaA	p.K244K	CFHR5_ENST00000256785.4_Silent_p.K220K	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	220	Sushi 4.				complement activation, alternative pathway	extracellular region		p.K220N(1)		NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						GTGAAGTTAAGGAGATAAGAA	0.338000													24	63					0	0	1	0	0
FAM19A2	338811	broad.mit.edu	37	12	62104181	62104181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:62104181C>T	ENST00000551449.1	-	3	302	c.124G>A	c.(124-126)Gag>Aag	p.E42K	FAM19A2_ENST00000416284.3_3'UTR|FAM19A2_ENST00000551619.1_3'UTR|FAM19A2_ENST00000550003.1_3'UTR			Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	0						cytoplasm				endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	15			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		CTTGATTTCTCCTGGGTTAAT	0.333000													51	133					0	0	1	0	0
IRAK3	11213	broad.mit.edu	37	12	66641931	66641931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:66641931G>A	ENST00000261233.4	+	12	2192	c.1771G>A	c.(1771-1773)Gaa>Aaa	p.E591K	IRAK3_ENST00000457197.2_Missense_Mutation_p.E530K	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	591					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		GGATGAATATGAACAGTACAA	0.418000													26	54					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837421	82837421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82837421G>A	ENST00000265077.3	+	8	9164	c.8599G>A	c.(8599-8601)Gaa>Aaa	p.E2867K	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.E1880K|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2867	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTCTTTTAAGGAAATTCATGT	0.458000													32	108					0	0	1	0	0
SLC29A1	2030	broad.mit.edu	37	6	44198553	44198553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44198553C>T	ENST00000393841.1	+	9	1184	c.693C>T	c.(691-693)ttC>ttT	p.F231F	SLC29A1_ENST00000472176.1_3'UTR|SLC29A1_ENST00000427851.2_Silent_p.F231F|SLC29A1_ENST00000371740.5_Silent_p.F231F|SLC29A1_ENST00000371724.1_Silent_p.F231F|SLC29A1_ENST00000371755.3_Silent_p.F231F|SLC29A1_ENST00000313248.7_Silent_p.F310F|SLC29A1_ENST00000371713.1_Silent_p.F231F|SLC29A1_ENST00000371731.1_Silent_p.F231F|SLC29A1_ENST00000393844.1_Silent_p.F231F|SLC29A1_ENST00000371708.1_Silent_p.F231F	NM_001078177.1	NP_001071645.1	Q99808	S29A1_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 1	231					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	17	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	GATAGGAATTCTACCGCTACT	0.547000													29	82					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179577424	179577424	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179577424C>T	ENST00000589042.1	-	94	27552	c.27328_splice	c.e94+1	p.A9110_splice	TTN_ENST00000342992.6_Splice_Site_p.A7866_splice|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Splice_Site_p.A8793_splice|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8793	Ig-like 74.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGACAAACCTTTTATGTAG	0.338000													32	82					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5486048	5486048	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:5486048C>T	ENST00000345221.3	-	2	944	c.390G>A	c.(388-390)caG>caA	p.Q130Q	NLRP1_ENST00000354411.3_Silent_p.Q130Q|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000262467.5_Silent_p.Q130Q|NLRP1_ENST00000577119.1_Silent_p.Q130Q|NLRP1_ENST00000572272.1_Silent_p.Q130Q|NLRP1_ENST00000269280.4_Silent_p.Q130Q	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	130					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				TCTCTGAGCCCTGGGTGCACC	0.632000													12	10					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256254	15256254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15256254C>T	ENST00000378116.4	-	8	1339	c.1333G>A	c.(1333-1335)Gat>Aat	p.D445N	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	445						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GTGAGGTTATCAAAGGAGATC	0.498000													23	51					0	0	1	0	0
KHK	3795	broad.mit.edu	37	2	27322557	27322557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27322557G>A	ENST00000260599.6	+	8	1349	c.836G>A	c.(835-837)aGa>aAa	p.R279K	CGREF1_ENST00000452318.2_3'UTR|KHK_ENST00000260598.5_Missense_Mutation_p.R279K|KHK_ENST00000490823.1_3'UTR|CGREF1_ENST00000402550.1_3'UTR	NM_000221.2	NP_000212.1	P50053	KHK_HUMAN	ketohexokinase (fructokinase)	279					fructose catabolic process	cytosol	ATP binding|ketohexokinase activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAGCACTGAGATTCGGGTGC	0.617000													15	32					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141025	143141025	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143141025C>T	ENST00000332690.1	+	1	480	c.480C>T	c.(478-480)ttC>ttT	p.F160F	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	160					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					TTCTATTTTTCATAGGCAACC	0.453000													55	170					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3312936	3312936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3312936G>A	ENST00000252032.9	-	11	1121	c.1054C>T	c.(1054-1056)Cct>Tct	p.P352S	C20orf194_ENST00000453730.2_Missense_Mutation_p.P91S	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	352										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						CCCAAGTAAGGAACATGAGTA	0.383000													9	17					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31386389	31386389	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31386389C>T	ENST00000328111.2	+	15	1935	c.1614C>T	c.(1612-1614)cgC>cgT	p.R538R	DNMT3B_ENST00000456297.2_Silent_p.R442R|DNMT3B_ENST00000344505.4_Silent_p.R518R|DNMT3B_ENST00000375623.4_3'UTR|DNMT3B_ENST00000201963.3_Silent_p.R530R|DNMT3B_ENST00000353855.2_Silent_p.R518R|DNMT3B_ENST00000348286.2_Silent_p.R518R|DNMT3B_ENST00000443239.3_Silent_p.R476R	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	538	ADD.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TCCTGCGGCGCCGGAAGGACT	0.637000													26	43					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46375450	46375450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46375450G>A	ENST00000302177.2	+	2	384	c.187G>A	c.(187-189)Gga>Aga	p.G63R		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	63					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		ACTGCCCTCAGGACCCCTGGC	0.706000													20	53					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110029765	110029765	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110029765C>T	ENST00000369870.3	+	4	450	c.435C>T	c.(433-435)tcC>tcT	p.S145S		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	145										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CGAAAACCTCCTCCAGGGAGA	0.622000													3	18					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70949081	70949081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70949081G>A	ENST00000334414.6	-	20	5046	c.5002C>T	c.(5002-5004)Cct>Tct	p.P1668S	PTPRB_ENST00000550857.1_Missense_Mutation_p.P1360S|PTPRB_ENST00000451516.2_Missense_Mutation_p.P1360S|PTPRB_ENST00000550358.1_Missense_Mutation_p.P1580S|PTPRB_ENST00000538708.1_Missense_Mutation_p.P1360S|PTPRB_ENST00000261266.5_Missense_Mutation_p.P1450S	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1450					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGGGGTGGAGGAGGGGGGCCT	0.483000													4	14					0	0	1	0	0
DNAJB6	10049	broad.mit.edu	37	7	157160088	157160088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157160088C>T	ENST00000262177.4	+	5	462	c.257C>T	c.(256-258)cCa>cTa	p.P86L	DNAJB6_ENST00000429029.2_Missense_Mutation_p.P86L|DNAJB6_ENST00000443280.1_Missense_Mutation_p.P86L|DNAJB6_ENST00000452797.2_Missense_Mutation_p.P37L	NM_058246.3	NP_490647.1	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	86	Gly/Phe-rich.|Interaction with HSP70.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			central_nervous_system(1)|lung(1)|ovary(2)|stomach(1)	5	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		TTTGACAGTCCATTTGAATTT	0.363000													19	177					0	0	1	0	0
SPATC1	375686	broad.mit.edu	37	8	145095248	145095248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145095248C>T	ENST00000377470.3	+	2	752	c.650C>T	c.(649-651)cCc>cTc	p.P217L	SPATC1_ENST00000447830.2_Missense_Mutation_p.P217L	NM_198572.2	NP_940974.2	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	217										NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGGCCAACCCCATGAGCAAC	0.682000													14	62					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940669	113940669	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113940669G>A	ENST00000245796.6	+	2	831	c.636G>A	c.(634-636)ggG>ggA	p.G212G	PSD4_ENST00000441564.2_Silent_p.G212G	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	212					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AAGACTCAGGGGAAGACAGCA	0.637000													8	35					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	6925673	6925673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6925673C>T	ENST00000409757.4	+	2	681	c.557C>T	c.(556-558)tCc>tTc	p.S186F	TBC1D14_ENST00000448507.1_Missense_Mutation_p.S186F	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	186						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						ACGAGCAGCTCCAGTGCCATT	0.552000													11	28					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	39966858	39966858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39966858C>T	ENST00000336649.4	+	1	101	c.101C>T	c.(100-102)tCc>tTc	p.S34F	CACNA1I_ENST00000404898.1_Missense_Mutation_p.S34F|CACNA1I_ENST00000402142.3_Missense_Mutation_p.S34F|CACNA1I_ENST00000401624.1_Missense_Mutation_p.S34F|CACNA1I_ENST00000400164.3_Missense_Mutation_p.S34F|CACNA1I_ENST00000407673.1_Missense_Mutation_p.S34F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	34					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCCCCATCCTCCCCGCCAGGC	0.682000													17	27					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61962829	61962829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61962829G>A	ENST00000280772.1	-	12	1514	c.1323C>T	c.(1321-1323)gcC>gcT	p.A441A	ANK3_ENST00000503366.1_Silent_p.A424A|ANK3_ENST00000373827.2_Silent_p.A435A	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	441					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCCCCATGAAGGCAGCAACAT	0.443000													29	51					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169656228	169656228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169656228G>A	ENST00000428432.2	+	9	1664	c.1275G>A	c.(1273-1275)atG>atA	p.M425I	SAMD7_ENST00000335556.3_Missense_Mutation_p.M425I	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	425										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GTGATACAATGAACATTTTTT	0.388000													21	40					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158262543	158262543	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158262543T>C	ENST00000368170.3	+	4	1047	c.768T>C	c.(766-768)ccT>ccC	p.P256P		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	256	Ig-like.				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					ATATTCTTCCTAATGCTGATG	0.527000													44	95					0	0	1	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31813035	31813035	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31813035G>A	ENST00000334067.3	+	1	439	c.390G>A	c.(388-390)agG>agA	p.R130R		NM_181623.1	NP_853654.1	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	130						intermediate filament				kidney(1)|large_intestine(3)|lung(6)|skin(1)	11						TTTCATCCAGGAATTTCCAGG	0.453000													44	119					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230687	147230687	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:147230687G>A	ENST00000271348.2	-	2	821	c.660C>T	c.(658-660)ctC>ctT	p.L220L	GJA5_ENST00000369237.1_Silent_p.L220L	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	220					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CCAGGCTAAGGAGGAGGGACA	0.562000													19	24					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3601144	3601144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:3601144C>T	ENST00000302006.3	+	4	1485	c.1433C>T	c.(1432-1434)cCg>cTg	p.P478L		NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	478						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GCAGCCCTCCCGTCCGCCTGA	0.587000													9	59					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37289169	37289169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37289169G>A	ENST00000233099.5	-	11	1704	c.1609C>T	c.(1609-1611)Ctt>Ttt	p.L537F	HEATR5B_ENST00000354531.2_Missense_Mutation_p.L537F	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	537							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				GTTCGTAAAAGATCTTCAGCA	0.343000													24	59					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155774885	155774885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155774885G>A	ENST00000437809.1	-	11	1622	c.1500C>T	c.(1498-1500)ccC>ccT	p.P500P	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Silent_p.P500P|GON4L_ENST00000368331.1_Silent_p.P500P|GON4L_ENST00000271883.5_Silent_p.P500P			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	500					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CATCTTTCAGGGGCATCTTAG	0.483000													31	94					0	0	1	0	0
TMEM203	94107	broad.mit.edu	37	9	140099732	140099732	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140099732G>A	ENST00000343666.5	-	1	358	c.135C>T	c.(133-135)tcC>tcT	p.S45S	TMEM203_ENST00000537254.1_Silent_p.S45S	NM_053045.1	NP_444273.1	Q969S6	TM203_HUMAN	transmembrane protein 203	45						integral to membrane				central_nervous_system(1)|kidney(1)	2	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CGTTCCACCAGGAGAGGCCCG	0.622000													5	22					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215802311	215802311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215802311G>A	ENST00000272895.7	-	51	7684	c.7465C>T	c.(7465-7467)Cac>Tac	p.H2489Y	AC072062.1_ENST00000607412.1_RNA|ABCA12_ENST00000389661.4_Missense_Mutation_p.H2171Y	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2489	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTCTTCAAGTGAACTTTGACA	0.368000													21	64					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100157211	100157211	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:100157211G>A	ENST00000370575.4	-	6	564	c.516C>T	c.(514-516)gcC>gcT	p.A172A	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	172							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						GAGGGTCAATGGCTAATGCCA	0.587000													21	55					0	0	1	0	0
OR4F15	390649	broad.mit.edu	37	15	102358521	102358521	+	Silent	SNP	C	C	T	rs143311907		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:102358521C>T	ENST00000332238.4	+	1	156	c.132C>T	c.(130-132)gtC>gtT	p.V44V		NM_001001674.1	NP_001001674.1	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F, member 15	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(10)	19	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			GAAACCTTGTCATTGTATTCA	0.413000													24	384					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402395	248402395	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248402395C>T	ENST00000306687.1	+	1	165	c.165C>T	c.(163-165)ctC>ctT	p.L55L		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGAAACAGCTCCACACCCCCA	0.483000													77	184					0	0	1	0	0
SLC26A6	65010	broad.mit.edu	37	3	48669750	48669750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48669750G>A	ENST00000358747.6	-	4	700	c.450C>T	c.(448-450)atC>atT	p.I150I	SLC26A6_ENST00000455886.2_Intron|SLC26A6_ENST00000337000.8_Intron|SLC26A6_ENST00000482282.1_5'UTR|SLC26A6_ENST00000420764.2_Silent_p.I171I|SLC26A6_ENST00000395550.2_Silent_p.I171I|SLC26A6_ENST00000383733.3_Silent_p.I171I	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CTGTCTCATTGATCATGGAGT	0.592000													26	27					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86940712	86940712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86940712C>T	ENST00000441037.2	+	17	2447	c.2352C>T	c.(2350-2352)ctC>ctT	p.L784L	AGBL1_ENST00000421325.2_Silent_p.L784L|AGBL1_ENST00000389298.3_Silent_p.L515L	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	784					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TGGCTAGGCTCTTGAGGGAAA	0.517000													32	138					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60754776	60754776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60754776C>T	ENST00000303375.5	+	12	2383	c.1981C>T	c.(1981-1983)Ccc>Tcc	p.P661S		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	661					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GGGGCCAGATCCCACGCCCAG	0.672000													7	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179666989	179666989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179666989G>A	ENST00000589042.1	-	3	395	c.171C>T	c.(169-171)tcC>tcT	p.S57S	TTN_ENST00000342992.6_Silent_p.S57S|TTN_ENST00000360870.5_Silent_p.S57S|TTN_ENST00000460472.2_Silent_p.S57S|TTN_ENST00000342175.6_Silent_p.S57S|TTN_ENST00000359218.5_Silent_p.S57S|TTN_ENST00000591111.1_Silent_p.S57S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	57	Ig-like 1.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCGCTAAAGGAGATCTGCA	0.527000													23	61					0	0	1	0	0
PPP1R12A	4659	broad.mit.edu	37	12	80182511	80182511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80182511G>A	ENST00000450142.2	-	21	2985	c.2719C>T	c.(2719-2721)Cgc>Tgc	p.R907C	PPP1R12A_ENST00000261207.5_Missense_Mutation_p.R907C|PPP1R12A_ENST00000550107.1_Missense_Mutation_p.R851C|PPP1R12A_ENST00000437004.2_Missense_Mutation_p.R907C|PPP1R12A_ENST00000546369.1_Missense_Mutation_p.R820C	NM_002480.2	NP_002471.1	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory subunit 12A	907						contractile fiber	protein binding|signal transducer activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|liver(1)|lung(4)|ovary(2)|skin(1)	29						GATCCAGAGCGACCCAGCAAG	0.353000													7	23					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187416366	187416366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:187416366G>A	ENST00000358241.1	-	2	1026	c.598C>T	c.(598-600)Cgc>Tgc	p.R200C		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	200					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding	p.R200C(1)		large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		AGGCACCAGCGAAGAGACAAG	0.592000													16	72					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	858969	858969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:858969C>T	ENST00000314167.4	-	23	3217	c.3107G>A	c.(3106-3108)gGa>gAa	p.G1036E	GAK_ENST00000511163.1_Missense_Mutation_p.G957E|GAK_ENST00000509566.1_5'UTR	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	1036					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GGCAGCCCATCCTCCCAGCAG	0.632000													24	32					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508413	37508413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37508413G>A	ENST00000374660.1	+	40	4061	c.3962G>A	c.(3961-3963)aGg>aAg	p.R1321K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.R1202K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.R1202K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1258						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GAAGCTCAAAGGAAATCCAAA	0.363000													13	54					0	0	1	0	0
ATP1A1	476	broad.mit.edu	37	1	116937852	116937852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:116937852C>T	ENST00000537345.1	+	13	2144	c.1781C>T	c.(1780-1782)cCt>cTt	p.P594L	ATP1A1_ENST00000369496.4_Missense_Mutation_p.P563L|ATP1A1_ENST00000295598.5_Missense_Mutation_p.P594L	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	594					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	ATGATTGACCCTCCACGGGCG	0.522000													16	130					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105330779	105330779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105330779G>A	ENST00000369780.4	+	2	645	c.236G>A	c.(235-237)aGc>aAc	p.S79N	NEURL_ENST00000369777.2_Missense_Mutation_p.S62N	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		79	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ATGGACCTCAGCCACAAGGCT	0.647000													17	120					0	0	1	0	0
OR7D4	125958	broad.mit.edu	37	19	9324872	9324872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9324872G>A	ENST00000308682.2	-	1	670	c.642C>T	c.(640-642)atC>atT	p.I214I		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						AGGAGAAGAGGATCCCAGCTA	0.527000													25	76					0	0	1	0	0
C14orf119	55017	broad.mit.edu	37	14	23566953	23566953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23566953C>T	ENST00000319074.4	+	2	942	c.86C>T	c.(85-87)cCt>cTt	p.P29L	C14orf119_ENST00000554203.1_Missense_Mutation_p.P29L	NM_017924.3	NP_060394.1	Q9NWQ9	CN119_HUMAN	chromosome 14 open reading frame 119	29										central_nervous_system(1)|endometrium(1)|lung(1)	3	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00649)		CCTTCCCCTCCTCTGATGTCT	0.483000													82	200					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75601358	75601358	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:75601358C>T	ENST00000549446.1	-	2	1086	c.406G>A	c.(406-408)Gag>Aag	p.E136K	KCNC2_ENST00000298972.1_Missense_Mutation_p.E136K|KCNC2_ENST00000341669.3_Missense_Mutation_p.E136K|KCNC2_ENST00000548513.1_Missense_Mutation_p.E136K|KCNC2_ENST00000393288.2_Missense_Mutation_p.E136K|KCNC2_ENST00000540018.1_Missense_Mutation_p.E136K|KCNC2_ENST00000550433.1_Missense_Mutation_p.E136K|KCNC2_ENST00000350228.2_Missense_Mutation_p.E136K	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	136					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						GCCAGCTCCTCCTCGAAGAGC	0.662000													20	42					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	56996002	56996002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56996002C>T	ENST00000200676.3	+	1	241	c.111C>T	c.(109-111)ctC>ctT	p.L37L	CETP_ENST00000379780.2_Silent_p.L37L|CETP_ENST00000569082.1_3'UTR	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	37					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						AGCCTGCCCTCCTGGTGTGTA	0.622000													12	43					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107041545	107041545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107041545C>T	ENST00000409886.3	-	20	2965	c.2878G>A	c.(2878-2880)Ggt>Agt	p.G960S	RGPD3_ENST00000304514.7_Missense_Mutation_p.G960S	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	960					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						AAAATCACACCACGGCCCTTC	0.403000													78	284					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91692774	91692774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91692774C>T	ENST00000375835.4	-	3	896	c.590G>A	c.(589-591)gGa>gAa	p.G197E	SHC3_ENST00000375830.1_5'UTR	NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	197	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						CTTGAAGGCTCCCTTCGCACC	0.483000													27	80					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167625888	167625888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167625888C>T	ENST00000519204.1	+	15	2686	c.2568C>T	c.(2566-2568)tcC>tcT	p.S856S	TENM2_ENST00000403607.2_Silent_p.S801S|TENM2_ENST00000545108.1_Silent_p.S977S|TENM2_ENST00000518659.1_Silent_p.S977S|TENM2_ENST00000520394.1_Silent_p.S745S					teneurin transmembrane protein 2																		GAGGTGCTTCCTTGACTCTAC	0.547000													23	98					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25343562	25343562	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25343562G>A	ENST00000354189.5	-	2	216	c.181C>T	c.(181-183)Ccc>Tcc	p.P61S	CASC1_ENST00000557684.1_Intron|CASC1_ENST00000545133.1_Intron|CASC1_ENST00000537577.1_Intron|CASC1_ENST00000395987.3_Missense_Mutation_p.P3S|CASC1_ENST00000395990.2_5'UTR|CASC1_ENST00000320267.9_Intron	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	0	Glu-rich.									breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TTTGCTTTGGGACCCTAAAAG	0.244000													19	48					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72022776	72022776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72022776G>A	ENST00000378743.3	-	20	4226	c.3868C>T	c.(3868-3870)Cca>Tca	p.P1290S		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1290					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CAAAACTTTGGCTTCCACTTT	0.308000													10	42					0	0	1	0	0
TRBV6-9	28598	broad.mit.edu	37	7	142104366	142104366	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142104366C>T	ENST00000390379.1	-	0	98																											TCTGTCCTGTCTTCAGGATGT	0.532000													11	115					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89259965	89259965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89259965G>A	ENST00000289746.2	+	12	2008	c.1943G>A	c.(1942-1944)cGa>cAa	p.R648Q		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	648					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GACGACCTTCGAGACAATGTC	0.672000													12	15					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748099	143748099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143748099C>T	ENST00000408906.2	+	1	639	c.605C>T	c.(604-606)gCt>gTt	p.A202V		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	202			A -> S (in dbSNP:rs6464573).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					ATCTTTGCTGCTTCAGTGTTC	0.582000													37	219					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112686832	112686832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:112686832C>T	ENST00000295408.4	+	2	454	c.197C>T	c.(196-198)tCa>tTa	p.S66L	MERTK_ENST00000421804.2_Missense_Mutation_p.S66L|MERTK_ENST00000409780.1_Intron			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	66					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TTGATGTTTTCACCAACCCAG	0.557000													13	40					0	0	1	0	0
NDC1	55706	broad.mit.edu	37	1	54272177	54272177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54272177G>A	ENST00000371429.3	-	9	1503	c.905C>T	c.(904-906)cCt>cTt	p.P302L	NDC1_ENST00000234725.8_Missense_Mutation_p.P187L|NDC1_ENST00000537333.1_5'UTR|NDC1_ENST00000540001.1_Missense_Mutation_p.P302L	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin									p.P302H(1)									TGGTTGAACAGGAAACACATG	0.348000													21	72					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711077	140711077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140711077G>A	ENST00000517417.1	+	1	826	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.E276K	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCAATGGGGAAGTAACGTA	0.438000													19	51					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103474059	103474059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103474059G>A	ENST00000358392.2	-	15	1996	c.1679C>T	c.(1678-1680)tCa>tTa	p.S560L	COL11A1_ENST00000370096.3_Missense_Mutation_p.S548L|COL11A1_ENST00000512756.1_Missense_Mutation_p.S432L|COL11A1_ENST00000353414.4_Missense_Mutation_p.S509L	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	548	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGCCCCAGATGAACCAGGCCC	0.373000													44	81					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20370265	20370265	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20370265C>T	ENST00000593655.1	-	0	199																											GTAATGCTTTCTTTTTTCTTT	0.418000													10	33					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166221716	166221716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166221716G>A	ENST00000375437.2	+	18	3753	c.3463G>A	c.(3463-3465)Gaa>Aaa	p.E1155K	SCN2A_ENST00000375427.2_Missense_Mutation_p.E1155K|SCN2A_ENST00000357398.3_Missense_Mutation_p.E1155K|SCN2A_ENST00000283256.6_Missense_Mutation_p.E1155K	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1155					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CGCCGAGGGAGAACAGCCTGA	0.413000													23	77					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151171418	151171418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151171418G>A	ENST00000282466.3	-	3	468	c.469C>T	c.(469-471)Ctg>Ttg	p.L157L		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	157					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGTGCACCAGGCGGAGAAAG	0.413000													34	85					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3683150	3683150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3683150G>A	ENST00000294600.2	+	9	1588	c.1504G>A	c.(1504-1506)Gaa>Aaa	p.E502K		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	502										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		GGGGCTCATTGAAAAGGACAA	0.507000													5	54					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62026817	62026817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62026817C>T	ENST00000578147.1	-	15	3001	c.2925G>A	c.(2923-2925)gaG>gaA	p.E975E	SCN4A_ENST00000435607.1_Silent_p.E975E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	975					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CCTCAGGGTCCTCCTCGGGGG	0.642000													8	9					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481366	123481366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123481366G>A	ENST00000280562.5	-	11	1769	c.1564C>T	c.(1564-1566)Ccc>Tcc	p.P522S	PITPNM2_ENST00000320201.4_Missense_Mutation_p.P522S|PITPNM2_ENST00000392428.1_Missense_Mutation_p.P243S|PITPNM2_ENST00000542749.1_Missense_Mutation_p.P522S			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	522					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGGTACTGGGGGGAGGAGGTG	0.617000													24	75					0	0	1	0	0
BMI1	648	broad.mit.edu	37	10	22616968	22616968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:22616968G>A	ENST00000376663.3	+	6	911	c.406G>A	c.(406-408)Gaa>Aaa	p.E136K	COMMD3-BMI1_ENST00000602390.1_Missense_Mutation_p.E279K	NM_005180.8	NP_005171.4			BMI1 polycomb ring finger oncogene											breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|urinary_tract(1)	12						CTTATCCATTGAATTCTTTGA	0.299000													28	79					0	0	1	0	0
KLRG1	10219	broad.mit.edu	37	12	9161639	9161639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9161639G>A	ENST00000266551.4	+	4	441	c.426G>A	c.(424-426)agG>agA	p.R142R	KLRG1_ENST00000356986.3_Silent_p.R142R|KLRG1_ENST00000538029.1_3'UTR	NM_005810.3	NP_005801.3	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G, member 1	142	C-type lectin.				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			breast(1)|central_nervous_system(1)|kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8						CTGGCTGGAGGTGGGAAGATG	0.448000													9	63					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54661819	54661819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54661819C>T	ENST00000474759.1	+	10	1017	c.969C>T	c.(967-969)ttC>ttT	p.F323F	CACNA2D3_ENST00000415676.2_Silent_p.F323F|CACNA2D3_ENST00000288197.5_Silent_p.F323F|CACNA2D3_ENST00000490478.1_Silent_p.F229F	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	323	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTCAGCACTTCAGGGAGCATC	0.418000													8	14					0	0	1	0	0
OR5AN1	390195	broad.mit.edu	37	11	59131945	59131945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59131945G>A	ENST00000313940.2	+	1	61	c.14G>A	c.(13-15)gGa>gAa	p.G5E		NM_001004729.1	NP_001004729.1	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN, member 1	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	21						ACTGGGGGAGGAAATATTACA	0.398000													18	50					0	0	1	0	0
TRBV10-1	28585	broad.mit.edu	37	7	142232050	142232050	+	RNA	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142232050T>G	ENST00000390364.3	-	0	40																											ATCTTGTGTCTCCCAGCCCTG	0.577000													7	35					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990859	39990859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39990859C>T	ENST00000332312.3	-	4	1542	c.1350G>A	c.(1348-1350)agG>agA	p.R450R		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	450						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				GACAGCATCCCCTTGCTCCAC	0.632000													66	111					0	0	1	0	0
ANKLE1	126549	broad.mit.edu	37	19	17394451	17394451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17394451C>T	ENST00000394458.3	+	5	1154	c.878C>T	c.(877-879)tCc>tTc	p.S293F	ANKLE1_ENST00000594072.1_Missense_Mutation_p.S282F|ANKLE1_ENST00000598347.1_Missense_Mutation_p.S293F|ANKLE1_ENST00000404085.1_Missense_Mutation_p.S315F|ANKLE1_ENST00000433424.2_Missense_Mutation_p.S347F	NM_152363.4	NP_689576.4	Q8NAG6	ANKL1_HUMAN	ankyrin repeat and LEM domain containing 1	293						nuclear envelope				large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	7						TCCTCCCCTTCCTCCATGCCT	0.622000													23	79					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901282	51901282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:51901282G>A	ENST00000268919.4	+	1	1044	c.888G>A	c.(886-888)atG>atA	p.M296I		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	296	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GCAAGGGCATGGCCACCTGCT	0.552000													26	74					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505354	159505354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159505354G>A	ENST00000334857.2	-	1	488	c.444C>T	c.(442-444)tcC>tcT	p.S148S		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					CAATGCCAAAGGACCCACACA	0.502000													26	72					0	0	1	0	0
PLAA	9373	broad.mit.edu	37	9	26928394	26928394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:26928394G>A	ENST00000397292.3	-	3	773	c.356C>T	c.(355-357)tCa>tTa	p.S119L	PLAA_ENST00000520884.1_Missense_Mutation_p.S119L	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	119					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TTTTCCAGATGATAGACTACA	0.358000													5	48					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87448052	87448052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:87448052G>A	ENST00000268616.4	-	10	1377	c.1160C>T	c.(1159-1161)cCc>cTc	p.P387L		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	387					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CGACTGCACGGGCCCGACGTG	0.672000													13	43					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181482	128181482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:128181482C>T	ENST00000469083.1	-	2	3164	c.607G>A	c.(607-609)Ggg>Agg	p.G203R	DNAJB8_ENST00000319153.3_Missense_Mutation_p.G203R			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	203					protein folding		heat shock protein binding|unfolded protein binding	p.G203W(1)		kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		CGCTCCTGCCCGTTCTCCACG	0.612000													43	97					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44624497	44624497	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:44624497C>T	ENST00000332990.5	-	6	793	c.777G>A	c.(775-777)caG>caA	p.Q259Q		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	259						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						CAAGAAGCTGCTGTCCTTCCA	0.448000													6	31					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98289599	98289599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:98289599C>T	ENST00000322128.3	-	1	577	c.474G>A	c.(472-474)agG>agA	p.R158R		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	158					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CCTGAGGCCCCCTCCCCGCGG	0.642000													49	113					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95423541	95423541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95423541G>A	ENST00000336148.5	-	4	431	c.307C>T	c.(307-309)Cat>Tat	p.H103Y		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding	p.H103D(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			GGAGCCGAATGAACTACAATT	0.313000								Direct reversal of damage;Homologous recombination					26	39					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71496142	71496142	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71496142C>G	ENST00000296755.7	+	5	7258	c.6960C>G	c.(6958-6960)acC>acG	p.T2320T		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2320						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ACAAGGAGACCAAGAATGCTG	0.507000													43	99					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628411	173628411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173628411C>T	ENST00000333279.2	-	2	207	c.147G>A	c.(145-147)gaG>gaA	p.E49E		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	65										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						TCTGCAAACCCTCTACATCCC	0.453000													20	34					0	0	1	0	0
RNFT2	84900	broad.mit.edu	37	12	117191865	117191865	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117191865G>A	ENST00000257575.4	+	5	860	c.627_splice	c.e5+1	p.K209_splice	RNFT2_ENST00000392549.2_Splice_Site_p.K209_splice|RNFT2_ENST00000407967.3_Splice_Site_p.K209_splice|RNFT2_ENST00000319176.7_Splice_Site_p.K209_splice			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	209						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		TCTCACTGAAGGTGAGTCACT	0.542000													21	52					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565115	20565115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20565115C>T	ENST00000329697.6	-	5	892	c.724G>A	c.(724-726)Gcc>Acc	p.A242T	ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565232.1_Missense_Mutation_p.A242T|ACSM2B_ENST00000565322.1_Missense_Mutation_p.A163T|ACSM2B_ENST00000567001.1_Missense_Mutation_p.A242T	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	242					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TCCATCTTGGCCTTGAGGCCC	0.517000													45	92					0	0	1	0	0
CELF2	10659	broad.mit.edu	37	10	11363309	11363309	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11363309C>T	ENST00000379261.4	+	11	1307	c.1215C>T	c.(1213-1215)agC>agT	p.S405S	CELF2_ENST00000416382.2_Silent_p.S405S|CELF2_ENST00000537122.1_Silent_p.S300S|CELF2_ENST00000354440.2_Silent_p.S387S|CELF2_ENST00000542579.1_Silent_p.S418S|CELF2_ENST00000450189.1_Silent_p.S418S|CELF2_ENST00000417956.2_Silent_p.S385S|CELF2_ENST00000354897.3_Silent_p.S399S|CELF2_ENST00000399850.3_Silent_p.S387S|CELF2_ENST00000315874.3_Silent_p.S387S|CELF2_ENST00000427450.1_Silent_p.S387S	NM_001025077.2	NP_001020248.1	O95319	CELF2_HUMAN	CUGBP, Elav-like family member 2	405	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	16						ACAGCCAGAGCCTGCTGCAGC	0.657000													18	41					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55568937	55568937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55568937C>T	ENST00000395445.1	-	36	5267	c.4873G>A	c.(4873-4875)Gaa>Aaa	p.E1625K	PCDH15_ENST00000395446.1_Missense_Mutation_p.E821K|PCDH15_ENST00000395442.1_Missense_Mutation_p.E490K|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395440.1_Missense_Mutation_p.E559K|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000409834.1_3'UTR	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GACTCAGATTCCTCTTCTGTA	0.458000										HNSCC(58;0.16)			31	50					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100451917	100451917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100451917G>A	ENST00000279907.7	-	14	3350	c.3138C>T	c.(3136-3138)atC>atT	p.I1046I	UHRF1BP1L_ENST00000545232.2_Silent_p.I696I	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1046										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						CAGCTTTAAAGATGGACTCTA	0.358000													30	81					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46308272	46308272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46308272C>T	ENST00000221538.3	-	3	1033	c.891G>A	c.(889-891)ggG>ggA	p.G297G	RSPH6A_ENST00000597055.1_Silent_p.G297G|RSPH6A_ENST00000600188.1_Silent_p.G33G	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	297						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						CTGGTGTCTCCCCCTGCGCAG	0.582000													8	55					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56139555	56139555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56139555C>T	ENST00000319441.4	+	8	1368	c.1204C>T	c.(1204-1206)Ccc>Tcc	p.P402S	PCK1_ENST00000535860.1_Missense_Mutation_p.P299L|PCK1_ENST00000543666.1_Missense_Mutation_p.P85S	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	402					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TTGTGCCCACCCCAACTCGAG	0.592000													34	95					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	56089453	56089453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:56089453G>A	ENST00000373965.2	-	7	1002	c.608C>T	c.(607-609)aCc>aTc	p.T203I	PCDH15_ENST00000395445.1_Missense_Mutation_p.T203I|PCDH15_ENST00000373957.3_Missense_Mutation_p.T181I|PCDH15_ENST00000395446.1_Missense_Mutation_p.T203I|PCDH15_ENST00000395442.1_Missense_Mutation_p.T203I|PCDH15_ENST00000414778.1_Missense_Mutation_p.T208I|PCDH15_ENST00000395433.1_Missense_Mutation_p.T181I|PCDH15_ENST00000395430.1_Missense_Mutation_p.T203I|PCDH15_ENST00000373955.1_Missense_Mutation_p.T203I|PCDH15_ENST00000395440.1_Missense_Mutation_p.T203I|PCDH15_ENST00000361849.3_Missense_Mutation_p.T203I|PCDH15_ENST00000395438.1_Missense_Mutation_p.T203I|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.T203I|PCDH15_ENST00000320301.6_Missense_Mutation_p.T203I|PCDH15_ENST00000395432.2_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	203	Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AATTTCAAAGGTGTCATTGGA	0.328000										HNSCC(58;0.16)			64	135					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88201751	88201751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:88201751G>A	ENST00000357081.3	-	22	3172	c.3028C>T	c.(3028-3030)Ccc>Tcc	p.P1010S	AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000376109.3_Missense_Mutation_p.P1022S|AGTPBP1_ENST00000376083.3_Missense_Mutation_p.P970S|AGTPBP1_ENST00000432218.1_Intron			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1010					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						CTTACCAAGGGTAAACGCTTC	0.373000													21	85					0	0	1	0	0
CST9	128822	broad.mit.edu	37	20	23584308	23584308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23584308C>T	ENST00000376971.3	-	2	330	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K		NM_001008693.2	NP_001008693.2	Q5W186	CST9_HUMAN	cystatin 9 (testatin)	107						extracellular region	cysteine-type endopeptidase inhibitor activity			central_nervous_system(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Colorectal(13;0.0993)					ATGTCATCTTCAAATTTCCTA	0.473000													15	221					0	0	1	0	0
DDX17	10521	broad.mit.edu	37	22	38884037	38884037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38884037G>A	ENST00000396821.3	-	12	1630	c.1531C>T	c.(1531-1533)Cgt>Tgt	p.R511C	DDX17_ENST00000381633.3_Missense_Mutation_p.R434C|DDX17_ENST00000444597.1_5'UTR	NM_001098504.1|NM_006386.4	NP_001091974.1|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	432					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					TTGGTGCTACGGGCTGTTCGG	0.483000													48	129					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61585240	61585240	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61585240C>T	ENST00000238508.3	+	4	335	c.276C>T	c.(274-276)ttC>ttT	p.F92F		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				ACTCTGATTTCCAAACACTTA	0.353000													22	71					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700713	136700713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:136700713G>A	ENST00000445907.2	+	3	1629	c.1101G>A	c.(1099-1101)aaG>aaA	p.K367K	CHRM2_ENST00000320658.5_Silent_p.K367K|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000401861.1_Silent_p.K367K|CHRM2_ENST00000397608.3_Silent_p.K367K|CHRM2_ENST00000402486.3_Silent_p.K367K|CHRM2_ENST00000453373.1_Silent_p.K367K|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000593789.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	367					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	AGATTGTGAAGATGACTAAGC	0.473000													33	58					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55761768	55761768	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55761768A>G	ENST00000278409.1	-	1	333	c.334T>C	c.(334-336)Tgc>Cgc	p.C112R		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					AAGAGGATGCATTCGGTTGTC	0.473000													44	127					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81702588	81702588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81702588G>A	ENST00000372292.3	-	3	287	c.247C>T	c.(247-249)Cca>Tca	p.P83S		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	83	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			GGCCCAACTGGGCCAGCTTGT	0.577000													41	87					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28136867	28136867	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28136867G>A	ENST00000316334.3	-	5	1036	c.907C>T	c.(907-909)Ctt>Ttt	p.L303F		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	303	PDZ 1.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		GGCTGGGAAAGGACAGCTCGG	0.453000													9	127					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24775148	24775148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24775148G>A	ENST00000221166.5	+	3	2562	c.1780G>A	c.(1780-1782)Gaa>Aaa	p.E594K	NEFM_ENST00000437366.2_Missense_Mutation_p.E594K|NEFM_ENST00000521540.1_Intron|NEFM_ENST00000433454.2_Missense_Mutation_p.E218K|NEFM_ENST00000518131.1_Intron			P07197	NFM_HUMAN	neurofilament, medium polypeptide	594	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		aaagagtgaggaagTGGCTAC	0.488000													11	26					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35255033	35255033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:35255033G>A	ENST00000360310.1	-	14	2348	c.1781C>T	c.(1780-1782)cCc>cTc	p.P594L	BAZ1A_ENST00000382422.2_Missense_Mutation_p.P594L|BAZ1A_ENST00000358716.4_Missense_Mutation_p.P562L	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	594					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CACTAGACTGGGATTGCTCAA	0.428000													12	125					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207872548	207872548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207872548G>A	ENST00000508064.2	+	8	1217	c.1157G>A	c.(1156-1158)gGc>gAc	p.G386D	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	386	Sushi 6.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CAATTAAAAGGCAGCTCTGCT	0.423000											OREG0014195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	93					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98764462	98764462	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98764462G>A	ENST00000266058.4	-	33	3943	c.3698C>T	c.(3697-3699)tCt>tTt	p.S1233F	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Missense_Mutation_p.S1233F	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1233	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GTAGATGGCAGAGCTGGGGTA	0.597000													17	56					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7110373	7110373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7110373G>A	ENST00000306904.5	+	1	209	c.22G>A	c.(22-24)Ggg>Agg	p.G8R		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	8	RRM.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGATCGCCCGGGGAAGCTGTT	0.632000													7	31					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197890485	197890485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197890485G>A	ENST00000367390.3	+	4	429	c.402G>A	c.(400-402)tcG>tcA	p.S134S	LHX9_ENST00000367391.1_Silent_p.S134S|LHX9_ENST00000367387.4_Silent_p.S143S|LHX9_ENST00000561173.1_Silent_p.S149S|LHX9_ENST00000337020.2_Silent_p.S143S	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	143	LIM zinc-binding 2.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						TTTCCGCCTCGGAGATGGTCA	0.577000													24	64					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	32109934	32109934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:32109934G>A	ENST00000396184.3	-	2	276	c.72C>T	c.(70-72)atC>atT	p.I24I	PDE1C_ENST00000396182.2_Silent_p.I24I|PDE1C_ENST00000396191.1_Silent_p.I24I|PDE1C_ENST00000321453.7_Silent_p.I24I|PDE1C_ENST00000396193.1_Intron	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	24					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			AGATTTTCTCGATCTGTTCCG	0.512000													18	135					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44777202	44777202	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44777202G>A	ENST00000391958.2	+	5	516	c.389G>A	c.(388-390)aGg>aAg	p.R130K	ZNF235_ENST00000589799.1_Intron|ZNF233_ENST00000592581.1_3'UTR|ZNF233_ENST00000334152.1_Intron	NM_181756.2	NP_861421.2	A6NK53	ZN233_HUMAN	zinc finger protein 233	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				CAAGGCAAGAGGTCCAAGTTG	0.383000													20	88					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21489199	21489199	+	Silent	SNP	C	C	T	rs142459106		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21489199C>T	ENST00000313654.9	+	55	7339	c.7098C>T	c.(7096-7098)atC>atT	p.I2366I	LAMA3_ENST00000587184.1_Silent_p.I701I|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000269217.6_Silent_p.I757I|LAMA3_ENST00000399516.3_Silent_p.I2310I	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2366	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGGAAACATCTCTGACAACA	0.458000													28	86					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6731807	6731807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:6731807G>A	ENST00000405858.1	-	5	1307	c.766C>T	c.(766-768)Ctc>Ttc	p.L256F	AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000404360.1_Missense_Mutation_p.L182F|ZNF12_ENST00000342651.5_Missense_Mutation_p.L218F	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	256					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TGTACAGTGAGGTCCGACATC	0.388000													18	52					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50534694	50534694	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50534694G>A	ENST00000267845.3	-	12	2154	c.1752C>T	c.(1750-1752)tcC>tcT	p.S584S	HDC_ENST00000543581.1_Silent_p.S551S	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	584					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TGCAACTGAGGGAGCGCACCG	0.542000													75	228					0	0	1	0	0
ELF1	1997	broad.mit.edu	37	13	41508052	41508052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:41508052G>A	ENST00000239882.3	-	9	1683	c.1369C>T	c.(1369-1371)Cca>Tca	p.P457S	ELF1_ENST00000498824.1_5'UTR|ELF1_ENST00000442101.1_Missense_Mutation_p.P433S	NM_172373.3	NP_758961.1	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription factor)	457					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		CCTGCTGATGGATCTGTGCTG	0.443000													26	271					0	0	1	0	0
DIO3	1735	broad.mit.edu	37	14	102028226	102028226	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102028226G>A	ENST00000359323.3	+	1	539	c.315G>A	c.(313-315)gaG>gaA	p.E105E	DIO3_ENST00000510508.4_Silent_p.E131E	NM_001362.3	NP_001353.4	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	105					cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(3)|skin(1)	22		all_neural(303;0.185)				AGGCGCACGAGGGCGGTCCGG	0.647000													38	58					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71744131	71744131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71744131C>T	ENST00000258104.3	+	9	1145	c.868C>T	c.(868-870)Cgt>Tgt	p.R290C	DYSF_ENST00000394120.2_Missense_Mutation_p.R291C|DYSF_ENST00000409744.1_Missense_Mutation_p.R291C|DYSF_ENST00000410020.3_Missense_Mutation_p.R322C|DYSF_ENST00000413539.2_Missense_Mutation_p.R321C|DYSF_ENST00000429174.2_Missense_Mutation_p.R290C|DYSF_ENST00000409366.1_Missense_Mutation_p.R291C|DYSF_ENST00000409582.3_Missense_Mutation_p.R321C|DYSF_ENST00000409762.1_Missense_Mutation_p.R321C|DYSF_ENST00000409651.1_Missense_Mutation_p.R322C|DYSF_ENST00000410041.1_Missense_Mutation_p.R322C	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	290	C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GGTAGACTCTCGTTCTCTCAG	0.498000													29	102					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71256160	71256160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71256160C>T	ENST00000260382.5	+	9	1070	c.810C>T	c.(808-810)tcC>tcT	p.S270S	LRRC49_ENST00000560369.1_Silent_p.S275S|LRRC49_ENST00000544974.2_Silent_p.S260S|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000443425.2_Silent_p.S226S|LRRC49_ENST00000560691.1_5'UTR|LRRC49_ENST00000560158.2_Intron	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	270						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						ACTCTTCTTCCCTCTCGGACA	0.433000													53	332					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47247066	47247066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47247066G>A	ENST00000300404.2	+	11	1736	c.1677G>A	c.(1675-1677)aaG>aaA	p.K559K	B4GALNT2_ENST00000504681.1_Silent_p.K473K|B4GALNT2_ENST00000393354.2_Silent_p.K499K	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	559					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			ACTACTTCAAGAACCATCTCC	0.522000													9	40					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105330819	105330819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105330819C>T	ENST00000369780.4	+	2	685	c.276C>T	c.(274-276)gcC>gcT	p.A92A	NEURL_ENST00000369777.2_Silent_p.A75A	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		92	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TCTGCAACGCCATCACCTTCA	0.662000													22	57					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158590148	158590148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158590148C>T	ENST00000368148.3	-	44	6409	c.6229G>A	c.(6229-6231)Gaa>Aaa	p.E2077K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E2074K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2077					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGCCGAATTTCATTCAGGGAG	0.473000													21	42					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42378415	42378415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42378415G>A	ENST00000290472.3	-	4	477	c.383C>T	c.(382-384)cCc>cTc	p.P128L		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	128					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		ACCCACCTGGGGACTCTGGGA	0.577000													3	4					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154207104	154207104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154207104C>T	ENST00000428931.1	+	5	484	c.317C>T	c.(316-318)tCa>tTa	p.S106L	UBAP2L_ENST00000271877.7_Missense_Mutation_p.S106L|UBAP2L_ENST00000343815.6_Missense_Mutation_p.S106L|UBAP2L_ENST00000361546.2_Missense_Mutation_p.S106L	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	106					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AAGGGAGTCTCAGGCCAGAAG	0.502000													14	51					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38766521	38766521	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38766521G>A	ENST00000310301.4	-	28	2526	c.2472C>T	c.(2470-2472)ccC>ccT	p.P824P	VPS41_ENST00000395969.2_Silent_p.P799P	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	824					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						TGCTGGGCATGGGCAGGCACT	0.512000													21	88					0	0	1	0	0
AKAP3	10566	broad.mit.edu	37	12	4736418	4736418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4736418G>A	ENST00000545990.2	-	5	2174	c.1650C>T	c.(1648-1650)ttC>ttT	p.F550F	AKAP3_ENST00000228850.1_Silent_p.F550F	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	550					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						CAGCTTCAACGAAGCTCCGTG	0.532000													17	40					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30749772	30749772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30749772C>T	ENST00000262518.4	+	34	8796	c.8411C>T	c.(8410-8412)cCc>cTc	p.P2804L	SRCAP_ENST00000395059.2_Missense_Mutation_p.P2742L|SRCAP_ENST00000344771.4_Missense_Mutation_p.P2646L	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2804	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCCTCCCCTCCCATTGGTGGG	0.642000													7	101					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57522848	57522848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57522848G>A	ENST00000420713.1	+	3	348	c.236G>A	c.(235-237)aGa>aAa	p.R79K		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						AATATAAAGAGAAATGAGATG	0.398000													21	125					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123479311	123479311	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123479311G>A	ENST00000450171.2	+	1	795	c.102G>A	c.(100-102)tgG>tgA	p.W34*	GRAMD1B_ENST00000456860.2_Intron|GRAMD1B_ENST00000322282.7_Intron|GRAMD1B_ENST00000529750.1_Intron			Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	0						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		GATGTCCCTGGGGCCCCCTCC	0.587000													5	9					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99124001	99124001	+	Silent	SNP	C	C	T	rs148650223		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99124001C>T	ENST00000394170.2	+	6	1589	c.1338C>T	c.(1336-1338)atC>atT	p.I446I	ZKSCAN5_ENST00000326775.5_Silent_p.I446I|ZKSCAN5_ENST00000451158.1_Silent_p.I446I	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	446					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CGCATCTGATCGAACACCTAA	0.507000													91	232					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22079283	22079283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22079283C>T	ENST00000454243.2	-	5	1150	c.576G>A	c.(574-576)acG>acA	p.T192T	PHYHIP_ENST00000321613.3_Silent_p.T192T	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	192										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		GGGGCTGGCCCGTGTTGAACT	0.627000													5	10					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33881335	33881335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33881335G>A	ENST00000504830.1	-	2	713	c.378C>T	c.(376-378)ctC>ctT	p.L126L	ADAMTS12_ENST00000352040.3_Silent_p.L126L|ADAMTS12_ENST00000515401.1_Silent_p.L126L	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	126					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.L126L(2)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TAACATGGGAGAGGTTCCCAT	0.502000										HNSCC(64;0.19)			28	86					0	0	1	0	0
IGHV3-21	28444	broad.mit.edu	37	14	106692191	106692191	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106692191C>T	ENST00000390607.2	-	0	12																											GCTAAGGCTCCTCTCTCAGAG	0.527000													23	71					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169535588	169535588	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169535588C>T	ENST00000449804.2	+	2	870	c.825C>T	c.(823-825)ctC>ctT	p.L275L	FOXI1_ENST00000306268.6_Silent_p.L370L	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	370					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTGGTGTCCTCTACCCCAGGG	0.577000									Pendred syndrome				33	85					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107408046	107408046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107408046C>T	ENST00000340010.5	-	20	2433	c.2249G>A	c.(2248-2250)gGa>gAa	p.G750E	SLC26A3_ENST00000422236.2_Missense_Mutation_p.G637E	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	750					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						ATTACGTAATCCTCCATTTGT	0.333000													13	26					0	0	1	0	0
ABCG5	64240	broad.mit.edu	37	2	44052128	44052128	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:44052128G>A	ENST00000260645.1	-	7	943	c.804C>T	c.(802-804)ttC>ttT	p.F268F	ABCG5_ENST00000543989.1_Intron|ABCG5_ENST00000405322.1_Intron	NM_022436.2	NP_071881.1	Q9H222	ABCG5_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 5	268	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCAGCTCTCCGAAGCTCAGGA	0.458000													13	34					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10228227	10228227	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10228227C>T	ENST00000377157.3	+	23	3558	c.2497C>T	c.(2497-2499)Cag>Tag	p.Q833*	UBE4B_ENST00000253251.8_Nonsense_Mutation_p.Q949*|UBE4B_ENST00000343090.6_Nonsense_Mutation_p.Q1078*	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	1078					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TCAGCTTGCTCAGGATGAGCG	0.587000													12	37					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2865964	2865964	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:2865964G>A	ENST00000254695.8	+	5	292	c.201_splice	c.e5-1	p.G68_splice	RAP1GAP2_ENST00000542807.1_Splice_Site_p.G68_splice|RAP1GAP2_ENST00000540393.2_Splice_Site_p.G49_splice|CTD-3060P21.1_ENST00000574885.1_RNA|RAP1GAP2_ENST00000366401.4_Intron	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	68					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GTTTCTATAGGGGATCAAGCT	0.567000													3	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179654826	179654826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179654826C>T	ENST00000589042.1	-	12	2041	c.1817G>A	c.(1816-1818)aGg>aAg	p.R606K	TTN_ENST00000342992.6_Missense_Mutation_p.R606K|TTN_ENST00000360870.5_Missense_Mutation_p.R606K|TTN_ENST00000460472.2_Missense_Mutation_p.R560K|TTN_ENST00000342175.6_Missense_Mutation_p.R560K|TTN_ENST00000359218.5_Missense_Mutation_p.R560K|TTN_ENST00000591111.1_Missense_Mutation_p.R606K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	606							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTGTTTTCCTAGTTTCCTT	0.313000													19	49					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363270	22363270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22363270C>T	ENST00000397121.2	-	3	1566	c.1249G>A	c.(1249-1251)Gga>Aga	p.G417R		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G417*(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GGTTTCTCTCCAGTATGAATT	0.433000													40	117					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87487804	87487804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87487804C>T	ENST00000327946.7	-	10	1426	c.1341G>A	c.(1339-1341)gaG>gaA	p.E447E	GRID1_ENST00000536331.1_Silent_p.E18E	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	447						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCACGAAAGGCTCTTCCTGAG	0.448000										Multiple Myeloma(13;0.14)			46	108					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31743967	31743967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31743967G>A	ENST00000375686.3	-	3	524	c.287C>T	c.(286-288)tCt>tTt	p.S96F	VWA7_ENST00000375688.4_Missense_Mutation_p.S96F|VWA7_ENST00000447450.1_Missense_Mutation_p.S96F|VWA7_ENST00000467576.1_5'UTR	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	96						extracellular region											CCGCCGAGAAGAACCAGGTCC	0.592000													34	91					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117122238	117122238	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117122238G>A	ENST00000307564.4	-	10	2390	c.2229C>T	c.(2227-2229)ccC>ccT	p.P743P	AKNA_ENST00000374075.5_Silent_p.P662P|AKNA_ENST00000374088.3_Silent_p.P743P|AKNA_ENST00000223791.3_Silent_p.P203P|AKNA_ENST00000312033.3_Silent_p.P743P	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	743					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						GTCGGGCCAGGGGGTCCTGTG	0.632000													21	37					0	0	1	0	0
HPGDS	27306	broad.mit.edu	37	4	95220653	95220653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:95220653C>T	ENST00000295256.5	-	6	668	c.578G>A	c.(577-579)cGa>cAa	p.R193Q		NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	193	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	TTGGGGCCTTCGTTTTATCCA	0.478000													35	57					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57252863	57252863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57252863G>A	ENST00000343433.6	-	4	1018	c.938C>T	c.(937-939)tCc>tTc	p.S313F	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	313										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TGGAGACAGGGAGCCCTCTTC	0.483000													39	66					0	0	1	0	0
CABYR	26256	broad.mit.edu	37	18	21739707	21739707	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21739707G>A	ENST00000399496.3	+	5	978	c.813G>A	c.(811-813)caG>caA	p.Q271Q	RP11-799B12.4_ENST00000583267.1_lincRNA|CABYR_ENST00000415309.2_Intron|CABYR_ENST00000399499.1_Silent_p.Q271Q|CABYR_ENST00000327201.6_Silent_p.Q173Q|CABYR_ENST00000581397.1_Silent_p.Q271Q	NM_012189.2|NM_153769.1	NP_036321.2|NP_722453.1	O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	0					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					AGGAAGCACAGGGATGGAAAC	0.458000													24	88					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16012579	16012579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16012579G>A	ENST00000350896.3	-	6	1089	c.892C>T	c.(892-894)Cca>Tca	p.P298S	MSR1_ENST00000445506.2_Missense_Mutation_p.P316S|MSR1_ENST00000536385.1_Missense_Mutation_p.P72S|MSR1_ENST00000381998.4_Missense_Mutation_p.P298S|MSR1_ENST00000262101.5_Missense_Mutation_p.P298S|MSR1_ENST00000355282.2_Missense_Mutation_p.P298S	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	298	Collagen-like.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATACCTATTGGACCTGGAAAT	0.398000													20	40					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207176205	207176205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207176205G>A	ENST00000374423.3	+	5	7339	c.6953G>A	c.(6952-6954)gGt>gAt	p.G2318D		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2318							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CGACAGAAAGGTCCTTCTACA	0.483000													17	16					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659107	196659107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196659107C>T	ENST00000312428.6	-	57	10771	c.10671G>A	c.(10669-10671)atG>atA	p.M3557I	DNAH7_ENST00000409063.1_Missense_Mutation_p.M40I	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3557	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGATCGGGTCCATGAGGTATG	0.458000													45	109					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19997289	19997289	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:19997289C>T	ENST00000391403.2	-	1	589	c.486G>A	c.(484-486)atG>atA	p.M162I		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	162						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					TCTTGAAGGTCATTTTGGCTT	0.378000													73	140					0	0	1	0	0
RC3H2	54542	broad.mit.edu	37	9	125622214	125622214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125622214G>A	ENST00000373670.1	-	10	2431	c.1831C>T	c.(1831-1833)Cca>Tca	p.P611S	RC3H2_ENST00000357244.2_Missense_Mutation_p.P611S|RC3H2_ENST00000423239.2_Missense_Mutation_p.P611S			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	611	Pro-rich.					cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GGGTACTGTGGGACTTCAAAG	0.353000													33	223					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135140051	135140051	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135140051G>A	ENST00000372169.2	-	27	7878	c.7696C>T	c.(7696-7698)Cag>Tag	p.Q2566*	SETX_ENST00000393220.1_Nonsense_Mutation_p.Q2504*|SETX_ENST00000477049.1_5'UTR|SETX_ENST00000224140.5_Nonsense_Mutation_p.Q2537*			Q7Z333	SETX_HUMAN	senataxin	2537					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CGTGGGTCCTGAAGTTGGTCA	0.502000													14	107					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7231040	7231040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7231040C>T	ENST00000379938.2	+	10	3245	c.2708C>T	c.(2707-2709)tCg>tTg	p.S903L	RREB1_ENST00000349384.6_Missense_Mutation_p.S903L|RREB1_ENST00000334984.6_Missense_Mutation_p.S903L|RREB1_ENST00000379933.3_Missense_Mutation_p.S903L	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	903					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CTGGACTTCTCGCAGAAGGGC	0.597000													33	79					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123699017	123699017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:123699017C>T	ENST00000334268.4	-	17	1530	c.1213G>A	c.(1213-1215)Gaa>Aaa	p.E405K	TRDN_ENST00000398178.3_Missense_Mutation_p.E405K			Q13061	TRDN_HUMAN	triadin	405					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		TTACCTGGTTCCACATGTTTT	0.249000													8	5					0	0	1	0	0
NPAT	4863	broad.mit.edu	37	11	108032498	108032498	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108032498G>A	ENST00000278612.8	-	17	3420	c.3315C>T	c.(3313-3315)tcC>tcT	p.S1105S		NM_002519.2	NP_002510.2	Q14207	NPAT_HUMAN	nuclear protein, ataxia-telangiectasia locus	1105					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		GTTTTAAGGTGGAGGACACAT	0.433000													26	66					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77455005	77455005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77455005C>T	ENST00000451710.3	-	5	716	c.479G>A	c.(478-480)aGc>aAc	p.S160N	TRPM6_ENST00000376864.4_Missense_Mutation_p.S160N|TRPM6_ENST00000449912.2_Missense_Mutation_p.S155N|TRPM6_ENST00000359047.2_Missense_Mutation_p.S160N|TRPM6_ENST00000360774.1_Missense_Mutation_p.S160N|TRPM6_ENST00000376871.3_Missense_Mutation_p.S160N|TRPM6_ENST00000361255.3_Missense_Mutation_p.S155N|TRPM6_ENST00000376872.3_Missense_Mutation_p.S160N			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	160					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CAAACCTTGGCTGAAAATCTC	0.453000													19	102					0	0	1	0	0
PRPF3	9129	broad.mit.edu	37	1	150316934	150316934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150316934C>T	ENST00000324862.6	+	12	1716	c.1551C>T	c.(1549-1551)gcC>gcT	p.A517A	PRPF3_ENST00000414970.2_Silent_p.A468A|PRPF3_ENST00000543398.1_3'UTR|PRPF3_ENST00000467329.1_3'UTR	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	517					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		CCAACGCTGCCCGAAAACTCA	0.468000													7	133					0	0	1	0	0
MSX2	4488	broad.mit.edu	37	5	174156247	174156247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:174156247C>T	ENST00000239243.6	+	2	592	c.465C>T	c.(463-465)ctC>ctT	p.L155L	MSX2_ENST00000507785.1_3'UTR	NM_002449.4	NP_002440.2	P35548	MSX2_HUMAN	msh homeobox 2	155					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	10	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCCAGCTCCTCGCCCTGGAGC	0.552000													18	45					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87556463	87556463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:87556463G>A	ENST00000436978.1	+	2	534	c.54G>A	c.(52-54)gaG>gaA	p.E18E	PTPN13_ENST00000316707.6_Silent_p.E18E|PTPN13_ENST00000411767.2_Silent_p.E18E|PTPN13_ENST00000511467.1_Silent_p.E18E|PTPN13_ENST00000502971.1_Silent_p.E18E|PTPN13_ENST00000427191.2_Silent_p.E18E	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	18	KIND.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CACTTCAGGAGGAAGAAATAT	0.453000													6	9					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72969065	72969065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72969065G>A	ENST00000261180.4	+	11	2123	c.2027G>A	c.(2026-2028)gGa>gAa	p.G676E	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	676					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTGGACAAAGGAAGCTGGCTG	0.333000													25	57					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51758030	51758030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51758030G>A	ENST00000543196.2	-	5	1129	c.924C>T	c.(922-924)ttC>ttT	p.F308F	GALNT6_ENST00000356317.3_Silent_p.F308F			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	308					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CGGGCTTGGCGAACTCAAAAG	0.582000													17	38					0	0	1	0	0
SH3BGR	6450	broad.mit.edu	37	21	40834415	40834415	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:40834415C>T	ENST00000333634.4	+	2	427	c.349C>T	c.(349-351)Cct>Tct	p.P117S	SH3BGR_ENST00000380631.1_Missense_Mutation_p.P6S|SH3BGR_ENST00000458295.1_Missense_Mutation_p.P6S|SH3BGR_ENST00000380637.3_Missense_Mutation_p.P6S|SH3BGR_ENST00000380634.1_Missense_Mutation_p.P6S	NM_007341.2	NP_031367.1	P55822	SH3BG_HUMAN	SH3 domain binding glutamic acid-rich protein	117					protein complex assembly	cytosol	SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(2)	8		all_cancers(19;1.16e-23)|all_epithelial(19;1.22e-20)|Prostate(19;2.55e-06)|Breast(209;0.0133)		STAD - Stomach adenocarcinoma(101;0.00151)		AGAGAATGTTCCTGGAGAGAA	0.418000													23	50					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62036634	62036634	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62036634G>A	ENST00000578147.1	-	12	2086	c.2010C>T	c.(2008-2010)tcC>tcT	p.S670S	SCN4A_ENST00000435607.1_Silent_p.S670S			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	670					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CCAGACGGAAGGAGCGTAGCA	0.597000													17	49					0	0	1	0	0
C5orf22	55322	broad.mit.edu	37	5	31541450	31541450	+	Silent	SNP	C	C	T	rs142007850	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31541450C>T	ENST00000325366.9	+	6	1060	c.933C>T	c.(931-933)ttC>ttT	p.F311F	C5orf22_ENST00000355907.3_5'UTR	NM_018356.2	NP_060826.2	Q49AR2	CE022_HUMAN	chromosome 5 open reading frame 22	311										kidney(3)|large_intestine(2)|lung(10)|ovary(2)|skin(1)	18						AAGCCACTTTCGCTGATTTGT	0.358000													7	72					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447461	226447461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:226447461G>A	ENST00000272907.6	+	4	1741	c.1328G>A	c.(1327-1329)gGg>gAg	p.G443E	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	443	Pro-rich.																GTCAGCATGGGGAGGTCCCTG	0.632000													25	44					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606746	55606746	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55606746C>T	ENST00000378396.1	+	1	519	c.519C>T	c.(517-519)ttC>ttT	p.F173F		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TTCATGGTTTCAACACAATCA	0.438000													8	63					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90650927	90650927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90650927C>T	ENST00000282146.4	+	2	1248	c.807C>T	c.(805-807)gtC>gtT	p.V269V		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	269						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				TCATGGGTGTCTGCTGCATCT	0.532000													36	88					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106285	55106285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55106285G>A	ENST00000453777.1	+	4	396	c.226G>A	c.(226-228)Gag>Aag	p.E76K	LILRA1_ENST00000251372.3_Missense_Mutation_p.E76K|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	76	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity	p.E76K(1)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GATCCCACAGGAGATTGTGAA	0.557000													47	106					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13867921	13867921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13867921G>A	ENST00000265104.4	-	25	4119	c.4015C>T	c.(4015-4017)Ctc>Ttc	p.L1339F	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1339	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CAATCTTGGAGGAATACCTCC	0.448000									Kartagener syndrome				39	92					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77631416	77631416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77631416G>A	ENST00000296043.6	+	3	1384	c.431G>A	c.(430-432)gGg>gAg	p.G144E	SHROOM3_ENST00000473602.1_3'UTR	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	144					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TGGTCAGGAGGGGTTAAACTT	0.567000													17	46					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26165144	26165144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26165144G>A	ENST00000335473.7	+	4	1511	c.1261G>A	c.(1261-1263)Gag>Aag	p.E421K	MYO18B_ENST00000536101.1_Missense_Mutation_p.E421K|MYO18B_ENST00000407587.2_Missense_Mutation_p.E421K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	421						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGCCCCAAAGGAGGTGAGCAC	0.607000													6	18					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66044946	66044946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:66044946C>T	ENST00000503581.1	-	11	2230	c.1693G>A	c.(1693-1695)Gaa>Aaa	p.E565K	EYS_ENST00000393380.2_Missense_Mutation_p.E565K|EYS_ENST00000370616.2_Missense_Mutation_p.E565K|EYS_ENST00000370618.3_Missense_Mutation_p.E565K|EYS_ENST00000370621.3_Missense_Mutation_p.E565K|EYS_ENST00000342421.5_Missense_Mutation_p.E565K	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	565					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GTTGTATTTTCCAGATACATG	0.358000													40	72					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75290181	75290181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75290181G>A	ENST00000339859.4	-	13	1648	c.1548C>T	c.(1546-1548)atC>atT	p.I516I	USP54_ENST00000319786.7_Silent_p.I516I|USP54_ENST00000497106.1_5'UTR|USP54_ENST00000394811.2_5'UTR|USP54_ENST00000428547.1_Silent_p.I366I|USP54_ENST00000408019.1_Silent_p.I516I			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	516					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					GTCTGTTATGGATCATATTGC	0.502000													17	65					0	0	1	0	0
MMP17	4326	broad.mit.edu	37	12	132334539	132334539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:132334539C>T	ENST00000360564.1	+	9	1499	c.1397C>T	c.(1396-1398)cCc>cTc	p.P466L	MMP17_ENST00000535291.1_Missense_Mutation_p.P382L|MMP17_ENST00000535004.1_Missense_Mutation_p.P6L	NM_016155.4	NP_057239.4	Q9ULZ9	MMP17_HUMAN	matrix metallopeptidase 17 (membrane-inserted)	466	Hemopexin-like 3.				proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CCCGGCTACCCCGCCCAGAGC	0.657000													30	44					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82467539	82467539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82467539C>T	ENST00000423517.2	-	15	14554	c.14217G>A	c.(14215-14217)ggG>ggA	p.G4739G	PCLO_ENST00000333891.8_Silent_p.G4739G|PCLO_ENST00000426442.2_5'UTR	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4610	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTTACCCTCTCCCTGGAAGAA	0.328000													8	18					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9730691	9730691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9730691C>T	ENST00000296003.4	+	16	1480	c.1358C>T	c.(1357-1359)tCc>tTc	p.S453F	MTMR14_ENST00000351233.5_Missense_Mutation_p.S453F|MTMR14_ENST00000353332.5_Missense_Mutation_p.S453F|MTMR14_ENST00000420925.1_Missense_Mutation_p.S207F	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	453						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					ATGGAGAGTTCCCCAGGAGCC	0.602000													31	72					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639261	7639261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7639261C>T	ENST00000359156.4	-	10	2494	c.2292G>A	c.(2290-2292)gaG>gaA	p.E764E	CD163_ENST00000432237.2_Silent_p.E764E|CD163_ENST00000396620.3_Silent_p.E797E|CD163_ENST00000541972.1_Silent_p.E752E	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	764	SRCR 7.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CATTAATGGCCTCTCCACAGC	0.532000													60	186					0	0	1	0	0
PLA2G2E	30814	broad.mit.edu	37	1	20249114	20249114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20249114C>T	ENST00000375116.3	-	2	232	c.175G>A	c.(175-177)Gac>Aac	p.D59N		NM_014589.1	NP_055404.1	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE	59					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCACCAGTCAGTCTGGTCC	0.627000													25	59					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187260	140187260	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140187260G>A	ENST00000530339.1	+	1	488	c.488G>A	c.(487-489)gGg>gAg	p.G163E	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.G163E|PCDHA4_ENST00000512229.2_Missense_Mutation_p.G163E|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1												p.G163V(2)		breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGATATCGGGGAGAACGCC	0.522000													31	88					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48603616	48603616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48603616G>A	ENST00000323776.5	+	14	2448	c.2286G>A	c.(2284-2286)gaG>gaA	p.E762E	MYCBPAP_ENST00000436259.2_Silent_p.E725E	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	725					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TCTGCTTGGAGGACTTCAGAA	0.577000													19	153					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849739	98849739	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:98849739G>A	ENST00000554295.1	-	0	1184					NR_033801.1																						TGATTCCACAGAAAAGGACAG	0.498000													16	119					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51696508	51696508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51696508C>T	ENST00000267012.4	-	4	335	c.274G>A	c.(274-276)Gag>Aag	p.E92K	BIN2_ENST00000544402.1_Missense_Mutation_p.E66K|BIN2_ENST00000452142.2_Missense_Mutation_p.E92K|BIN2_ENST00000604560.1_Missense_Mutation_p.E65K	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	92	BAR.					cytoplasm	protein binding	p.E92K(1)		NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						CCGTCCCACTCGCTGCTGTAG	0.473000													69	182					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91657096	91657096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91657096G>A	ENST00000375835.4	-	10	1511	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	SHC3_ENST00000375830.1_5'UTR	NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	402	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						GATGTCCGAGGACCCTGCAAC	0.547000													26	114					0	0	1	0	0
SAMD4A	23034	broad.mit.edu	37	14	55168827	55168827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:55168827C>T	ENST00000251091.5	+	2	549	c.244C>T	c.(244-246)Ctc>Ttc	p.L82F	SAMD4A_ENST00000554335.1_Missense_Mutation_p.L82F|SAMD4A_ENST00000357634.3_Missense_Mutation_p.L81F|SAMD4A_ENST00000392067.3_Missense_Mutation_p.L82F|SAMD4A_ENST00000555112.1_3'UTR	NM_001161576.2	NP_001155048.2	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4A	82					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)	29						AGTGATTTCCCTCCTGTTAAC	0.423000													15	65					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68280418	68280418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:68280418G>A	ENST00000433211.1	-	11	1662	c.1488C>T	c.(1486-1488)gcC>gcT	p.A496A	CTNNA3_ENST00000373744.4_Silent_p.A496A	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	496					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TGTCATCTACGGCTTCAGTGA	0.358000													41	77					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1536177	1536177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1536177G>A	ENST00000447419.2	-	3	1225	c.1200C>T	c.(1198-1200)tcC>tcT	p.S400S	PTX4_ENST00000293922.1_Silent_p.S395S|PTX4_ENST00000440447.2_3'UTR			Q96A99	PTX4_HUMAN	pentraxin 4, long	400	Pentaxin.					extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						CCAGCACGAGGGACCCTCCGG	0.682000													14	35					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370417	126370417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126370417G>A	ENST00000394329.3	+	9	8259	c.8246G>A	c.(8245-8247)gGg>gAg	p.G2749E	FAT4_ENST00000335110.5_Missense_Mutation_p.G1047E	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2749	Cadherin 26.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCAGACAAAGGGTCCCCGTCT	0.373000													44	99					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56138689	56138689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56138689G>A	ENST00000319441.4	+	6	1031	c.867G>A	c.(865-867)ggG>ggA	p.G289G	PCK1_ENST00000535860.1_Silent_p.G157G|PCK1_ENST00000543666.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	289					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GCGCCTGCGGGAAGACCAACC	0.547000													47	84					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	67022482	67022482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67022482C>T	ENST00000529006.2	+	21	3891	c.3445C>T	c.(3445-3447)Ctc>Ttc	p.L1149F	KDM2A_ENST00000308783.5_Missense_Mutation_p.L607F|KDM2A_ENST00000530342.1_Missense_Mutation_p.L710F|KDM2A_ENST00000526258.1_3'UTR|KDM2A_ENST00000398645.2_3'UTR	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	1149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						CATCAACAGCCTCTACTGCCT	0.532000													3	12					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422852	26422852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26422852G>A	ENST00000335473.7	+	43	7162	c.6912G>A	c.(6910-6912)agG>agA	p.R2304R	MYO18B_ENST00000536101.1_Silent_p.R2304R|MYO18B_ENST00000407587.2_Silent_p.R2305R	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2304						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TCTCGCTGAGGGTTGGGGCAA	0.607000													13	26					0	0	1	0	0
PTPRA	5786	broad.mit.edu	37	20	3002768	3002768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3002768C>T	ENST00000216877.6	+	14	1603	c.1203C>T	c.(1201-1203)gaC>gaT	p.D401D	PTPRA_ENST00000318266.5_Silent_p.D401D|PTPRA_ENST00000358719.4_Silent_p.D266D|PTPRA_ENST00000380393.3_Silent_p.D410D|PTPRA_ENST00000399903.2_Silent_p.D410D|PTPRA_ENST00000425918.2_Silent_p.D421D|PTPRA_ENST00000356147.3_Silent_p.D401D	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	410	Tyrosine-protein phosphatase 1.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GCTGGCCAGACTTTGGGGTGC	0.562000													32	94					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236902625	236902625	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236902625G>A	ENST00000366578.4	+	10	1066	c.900G>A	c.(898-900)acG>acA	p.T300T	ACTN2_ENST00000542672.1_Silent_p.T300T|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_Intron	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	300					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding	p.T300T(1)		endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TTCGTCGCACGATCCCCTGGC	0.532000													61	141					0	0	1	0	0
MIOX	55586	broad.mit.edu	37	22	50927995	50927995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50927995C>T	ENST00000395732.3	+	9	693	c.671C>T	c.(670-672)cCc>cTc	p.P224L	MIOX_ENST00000395733.3_Intron|MIOX_ENST00000216075.6_Missense_Mutation_p.P224L			Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	224					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	13		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCCTTCTACCCCTGGCACACG	0.682000													16	28					0	0	1	0	0
MRAP	56246	broad.mit.edu	37	21	33684189	33684189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:33684189G>A	ENST00000399784.2	+	5	588	c.401G>A	c.(400-402)gGg>gAg	p.G134E	MRAP_ENST00000303645.5_Missense_Mutation_p.G134E|MRAP_ENST00000399786.3_Intron|MRAP_ENST00000497833.1_3'UTR|MRAP_ENST00000339944.4_Intron|URB1_ENST00000382751.3_3'UTR	NM_178817.3	NP_848932.1	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	134					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			endometrium(1)|large_intestine(2)|lung(3)	6						TTGCCCCTCGGGGGTTTCCAG	0.662000													21	44					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141722084	141722084	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141722084G>T	ENST00000475668.2	+	7	781	c.727G>T	c.(727-729)Ggg>Tgg	p.G243W	MGAM_ENST00000549489.2_Missense_Mutation_p.G243W			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	243	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTCGAGCATTGGGCCCCTACT	0.522000													12	60					2.27111e-07	2.27728e-07	1	1	0
GPR98	84059	broad.mit.edu	37	5	89938713	89938713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89938713G>A	ENST00000405460.2	+	13	2504	c.2408G>A	c.(2407-2409)gGg>gAg	p.G803E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	803					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CGATCAAGGGGGTCCCTTGTT	0.408000													40	107					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179597799	179597799	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:179597799G>A	ENST00000467460.1	-	5	753	c.423C>T	c.(421-423)gcC>gcT	p.A141A	PEX5L_ENST00000485199.1_Silent_p.A106A|PEX5L-AS1_ENST00000466064.1_RNA|PEX5L_ENST00000476138.1_Silent_p.A98A|PEX5L_ENST00000465751.1_Silent_p.A117A|PEX5L_ENST00000472994.1_Silent_p.A82A|PEX5L_ENST00000468741.1_5'UTR|PEX5L_ENST00000467440.2_Intron|PEX5L_ENST00000464614.1_Intron|PEX5L_ENST00000392649.3_Intron|PEX5L_ENST00000263962.8_Silent_p.A139A	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	141					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CAGATCCATCGGCCTTTTTCT	0.517000													19	74					0	0	1	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337041	22337041	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22337041G>A	ENST00000390436.2	+	0	22																											GGAAGAACAAGGATGACATCC	0.423000													16	30					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65499330	65499330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65499330C>T	ENST00000261883.4	-	4	380	c.214G>A	c.(214-216)Gag>Aag	p.E72K		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	72					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TCCAGCCGCTCATAGTCGCCC	0.612000													21	21					0	0	1	0	0
CIDEA	1149	broad.mit.edu	37	18	12274239	12274239	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:12274239G>A	ENST00000320477.9	+	4	543	c.478G>A	c.(478-480)Gac>Aac	p.D160N	CIDEA_ENST00000521296.1_3'UTR	NM_001279.3	NP_001270.1	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a	160					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity	p.D194N(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)	13						CGTGTCCTACGACATCCGGTG	0.587000													26	67					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69171531	69171531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:69171531C>T	ENST00000420581.2	-	1	186	c.7G>A	c.(7-9)Gag>Aag	p.E3K	LMOD3_ENST00000489031.1_Missense_Mutation_p.E3K|LMOD3_ENST00000475434.1_Missense_Mutation_p.E3K	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	3						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		CTGCTGTGCTCTGACATTATT	0.333000													11	21					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237246931	237246931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237246931G>A	ENST00000409907.3	-	17	2325	c.2051C>T	c.(2050-2052)cCc>cTc	p.P684L	IQCA1_ENST00000431676.2_Missense_Mutation_p.P643L|IQCA1_ENST00000309507.5_Missense_Mutation_p.P681L			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	684							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						AGCATCGAAGGGACGCCGTGT	0.488000													22	48					0	0	1	0	0
CRYBB2	1415	broad.mit.edu	37	22	25620922	25620922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25620922C>T	ENST00000398215.2	+	3	263	c.92C>T	c.(91-93)tCg>tTg	p.S31L		NM_000496.2	NP_000487.1	P43320	CRBB2_HUMAN	crystallin, beta B2	31	Beta/gamma crystallin 'Greek key' 1.				response to stimulus|visual perception		structural constituent of eye lens			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	10						CAAGGCCACTCGCATGAGCTC	0.547000													24	43					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23410745	23410745	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23410745C>T	ENST00000379361.4	+	3	1970	c.1110C>T	c.(1108-1110)gaC>gaT	p.D370D		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	370	SSD.				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TCTATGCAGACTCCATGCTCT	0.468000													17	42					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46930755	46930755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46930755C>T	ENST00000264318.3	-	9	2134	c.1152G>A	c.(1150-1152)ttG>ttA	p.L384L		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	384					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTCTCATGTTCAAATTGGCAT	0.318000													16	43					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61505556	61505556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:61505556G>A	ENST00000398571.2	-	40	5355	c.5279C>T	c.(5278-5280)gCc>gTc	p.A1760V		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1760					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TCTTGCCAAGGCATCTAAGTC	0.269000													11	20					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13112081	13112081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:13112081G>A	ENST00000319217.7	-	43	5913	c.5666C>T	c.(5665-5667)cCt>cTt	p.P1889L	MPDZ_ENST00000541718.1_Missense_Mutation_p.P1860L|MPDZ_ENST00000447879.1_Missense_Mutation_p.P1856L|MPDZ_ENST00000381015.4_Missense_Mutation_p.P1889L|MPDZ_ENST00000541093.1_Missense_Mutation_p.P123L|MPDZ_ENST00000536827.1_Missense_Mutation_p.P1827L|MPDZ_ENST00000538841.1_Missense_Mutation_p.P748L|MPDZ_ENST00000381022.2_Missense_Mutation_p.P1860L|MPDZ_ENST00000546205.1_Missense_Mutation_p.P1903L	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1889	PDZ 12.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		AATAAATATAGGCACATCACC	0.473000													14	23					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018992	161018992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161018992C>T	ENST00000368013.3	-	12	2139	c.1819G>A	c.(1819-1821)Gaa>Aaa	p.E607K	ARHGAP30_ENST00000368015.1_Missense_Mutation_p.E430K|ARHGAP30_ENST00000368016.3_Missense_Mutation_p.E607K	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	607					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AGGAAAACTTCCTCCCCATTT	0.572000													68	153					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027525	37027525	+	Missense_Mutation	SNP	G	G	A	rs139443110		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37027525G>A	ENST00000358047.3	+	1	1094	c.1042G>A	c.(1042-1044)Gag>Aag	p.E348K		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	348										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGAGCCTCCCGAGACTGGAGT	0.627000													61	48					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171254565	171254565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171254565G>A	ENST00000354841.4	+	8	1612	c.1481G>A	c.(1480-1482)cGa>cAa	p.R494Q	FMO1_ENST00000402921.2_Missense_Mutation_p.R431Q|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.R494Q			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	494					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGTGGGACCGAACATTCAAG	0.478000													46	37					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10555862	10555862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10555862C>T	ENST00000583535.1	-	4	310	c.223G>A	c.(223-225)Gag>Aag	p.E75K	MYH3_ENST00000226209.7_Missense_Mutation_p.E75K	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	75	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TACACATCCTCTGGTTTGACC	0.463000													34	51					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160851014	160851014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160851014G>A	ENST00000326245.3	-	5	609	c.494C>T	c.(493-495)tCc>tTc	p.S165F	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	165	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCTCAGCAGGGAGCTGTTTCT	0.567000													48	90					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169086465	169086465	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169086465G>A	ENST00000359299.3	+	6	654	c.468G>A	c.(466-468)atG>atA	p.M156I		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	156							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		ATACTCTCATGAACTTGGTCC	0.323000													46	72					0	0	1	0	0
TBC1D5	9779	broad.mit.edu	37	3	17279774	17279774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:17279774G>A	ENST00000253692.7	-	17	3133	c.1469C>T	c.(1468-1470)tCc>tTc	p.S490F	TBC1D5_ENST00000429924.2_Missense_Mutation_p.S442F|TBC1D5_ENST00000429383.4_Missense_Mutation_p.S490F|TBC1D5_ENST00000446818.2_Missense_Mutation_p.S490F|TBC1D5_ENST00000414318.2_5'UTR	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	490						intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						AACAGAGGAGGAGCTACTGCT	0.512000													14	55					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10273996	10273996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10273996G>A	ENST00000396573.2	-	3	582	c.273C>T	c.(271-273)tcC>tcT	p.S91S	GRIN2A_ENST00000404927.2_Silent_p.S91S|GRIN2A_ENST00000562109.1_Silent_p.S91S|GRIN2A_ENST00000330684.3_Silent_p.S91S|GRIN2A_ENST00000396575.2_Silent_p.S91S	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	91					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGCGTGCCCCGGACATGAGGT	0.637000													27	110					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347137	57347137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57347137G>A	ENST00000361249.3	+	5	580	c.484G>A	c.(484-486)Gaa>Aaa	p.E162K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	162	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CCTGACCCAGGAAGATGCTCA	0.458000													37	93					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36459857	36459857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:36459857G>A	ENST00000265748.2	+	11	2170	c.1949G>A	c.(1948-1950)aGa>aAa	p.R650K	ANLN_ENST00000396068.2_Missense_Mutation_p.R613K	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	650	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						AAATTCCAAAGAACTCGTGTC	0.433000													27	82					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529546	57529546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57529546G>A	ENST00000420713.1	+	4	1491	c.1379G>A	c.(1378-1380)gGa>gAa	p.G460E		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						ATTCATACTGGAGAGAAACCC	0.358000													8	10					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32089063	32089063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32089063G>A	ENST00000375201.4	-	6	577	c.532C>T	c.(532-534)Ctc>Ttc	p.L178F	ATF6B_ENST00000375203.3_Missense_Mutation_p.L181F			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	181					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						TCGGCTGAGAGCAGGGAGGCC	0.537000													5	22					0	0	1	0	0
TMEM57	55219	broad.mit.edu	37	1	25812187	25812187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:25812187C>T	ENST00000374343.4	+	8	1576	c.1397C>T	c.(1396-1398)gCc>gTc	p.A466V	TMEM57_ENST00000399763.3_Missense_Mutation_p.A108V|TMEM57_ENST00000399766.3_Missense_Mutation_p.A239V	NM_018202.4	NP_060672.2	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	466						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part				breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCAGGAAGCCCGAAGTTTT	0.428000													28	119					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210595031	210595031	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:210595031C>T	ENST00000360351.4	+	15	5900	c.5394C>T	c.(5392-5394)tcC>tcT	p.S1798S	MAP2_ENST00000447185.1_Silent_p.S1794S|MAP2_ENST00000199940.6_Silent_p.S530S|MAP2_ENST00000361559.4_Silent_p.S442S|MAP2_ENST00000392194.1_Silent_p.S442S	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1798					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GCAATGTCTCCTCGTCTGGAA	0.547000													11	50					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216348787	216348787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216348787G>A	ENST00000366943.2	-	21	4820	c.4434C>T	c.(4432-4434)atC>atT	p.I1478I	USH2A_ENST00000307340.3_Silent_p.I1478I|USH2A_ENST00000366942.3_Silent_p.I1478I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1478					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGTGCTGTTGATTCCTTTAA	0.418000										HNSCC(13;0.011)			17	49					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50744969	50744969	+	Missense_Mutation	SNP	G	G	A	rs104895477		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50744969G>A	ENST00000300589.2	+	4	1252	c.1147G>A	c.(1147-1149)Gag>Aag	p.E383K		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	383	NACHT.		E -> K (in BS).		activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TGGCTTTGACGAGTTCAAGTT	0.542000													24	55					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33584242	33584242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33584242G>A	ENST00000262873.7	+	27	3255	c.3163G>A	c.(3163-3165)Gcc>Acc	p.A1055T		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1013						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CCACCAACAGGCCCTGGGTGA	0.657000													18	17					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61747817	61747817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:61747817C>T	ENST00000577390.1	-	10	2536	c.1582G>A	c.(1582-1584)Gga>Aga	p.G528R	CDH8_ENST00000580044.1_5'UTR|CDH8_ENST00000299345.6_Missense_Mutation_p.G528R|CDH8_ENST00000577730.1_Missense_Mutation_p.G528R	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	528	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AAATAATGTCCGTTTTTGGGA	0.378000													44	35					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45817280	45817280	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45817280G>A	ENST00000358525.4	-	4	670	c.555C>T	c.(553-555)atC>atT	p.I185I	SLC6A20_ENST00000353278.4_Silent_p.I185I|SLC6A20_ENST00000456124.2_Silent_p.I185I	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	185					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		TGCCACGCAGGATGCACAGGT	0.657000													31	73					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59545008	59545008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59545008C>T	ENST00000393853.4	+	5	702	c.539C>T	c.(538-540)cCc>cTc	p.P180L	TBX4_ENST00000240335.1_Missense_Mutation_p.P180L			P57082	TBX4_HUMAN	T-box 4	180					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CACCTGGACCCCTTTGGCCAT	0.602000													27	73					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409179	105409179	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105409179C>T	ENST00000333244.5	-	7	12728	c.12609G>A	c.(12607-12609)gaG>gaA	p.E4203E	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4203						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCAGGGGGCCCTCCGGGAGTT	0.652000													81	190					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167164253	167164253	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167164253C>T	ENST00000476257.1	-	9	1366	c.1068G>A	c.(1066-1068)gtG>gtA	p.V356V	SERPINI2_ENST00000471111.1_Silent_p.V356V|SERPINI2_ENST00000264677.4_Silent_p.V356V|SERPINI2_ENST00000461846.1_Silent_p.V356V			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	356					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						GACTCATGATCACAGGGATGT	0.318000													24	106					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28971146	28971146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28971146G>A	ENST00000359747.4	+	7	819	c.790G>A	c.(790-792)Gat>Aat	p.D264N	DSG4_ENST00000308128.4_Missense_Mutation_p.D264N|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	264	Cadherin 2.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGACGTCAACGATAATTTCCC	0.388000													29	72					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53327118	53327118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:53327118C>T	ENST00000395631.2	-	13	1884	c.1668G>A	c.(1666-1668)atG>atA	p.M556I	FERMT2_ENST00000343279.4_Missense_Mutation_p.M563I|FERMT2_ENST00000399304.3_Missense_Mutation_p.M563I|FERMT2_ENST00000341590.3_Missense_Mutation_p.M556I|FERMT2_ENST00000557255.1_5'UTR|FERMT2_ENST00000553373.1_Missense_Mutation_p.M563I			Q96AC1	FERM2_HUMAN	fermitin family member 2	556	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					GAATAAATCTCATCTTGGCTT	0.403000													9	54					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160049500	160049500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:160049500C>T	ENST00000327245.5	-	14	2559	c.1713G>A	c.(1711-1713)aaG>aaA	p.K571K	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	571					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAGGGAAGCCTTGGCAGGTC	0.522000													29	58					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26222391	26222391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26222391G>A	ENST00000335473.7	+	14	2961	c.2711G>A	c.(2710-2712)gGa>gAa	p.G904E	MYO18B_ENST00000536101.1_Missense_Mutation_p.G904E|MYO18B_ENST00000407587.2_Missense_Mutation_p.G904E	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	904	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AAGATGACAGGAGTGGACTGT	0.562000													29	83					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451179	138451179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138451179C>T	ENST00000344876.4	-	1	2450	c.2064G>A	c.(2062-2064)atG>atA	p.M688I	PCDH18_ENST00000412923.2_Missense_Mutation_p.M688I|PCDH18_ENST00000507846.1_Missense_Mutation_p.M468I|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	688	Cadherin 6.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TTACTGAAGTCATTGCTGTAC	0.408000													70	170					0	0	1	0	0
LDHA	3939	broad.mit.edu	37	11	18425294	18425294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18425294C>T	ENST00000422447.3	+	6	919	c.646C>T	c.(646-648)Cca>Tca	p.P216S	LDHA_ENST00000542179.1_Missense_Mutation_p.P216S|LDHA_ENST00000379412.5_Missense_Mutation_p.P216S|LDHA_ENST00000540430.1_Missense_Mutation_p.P245S|LDHA_ENST00000430553.2_Missense_Mutation_p.P158S|LDHA_ENST00000227157.4_Missense_Mutation_p.P216S|LDHA_ENST00000396222.2_Missense_Mutation_p.P216S	NM_001135239.1|NM_005566.3	NP_001128711.1|NP_005557.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	216					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	GACTCTGCACCCAGATTTAGG	0.383000													11	111					0	0	1	0	0
NACC2	138151	broad.mit.edu	37	9	138903368	138903368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138903368G>A	ENST00000371753.1	-	5	1816	c.1758C>T	c.(1756-1758)acC>acT	p.T586T	NACC2_ENST00000277554.2_Silent_p.T586T			Q96BF6	NACC2_HUMAN	NACC family member 2, BEN and BTB (POZ) domain containing	586					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization	nuclear body				endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5						CCGCTTACAAGGTCCCTGCAT	0.647000													30	48					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68021793	68021793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68021793G>A	ENST00000412757.2	-	11	1833	c.1168C>T	c.(1168-1170)Cgt>Tgt	p.R390C	DPEP2_ENST00000393847.1_Missense_Mutation_p.R390C|DPEP2_ENST00000572888.1_Missense_Mutation_p.R390C			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	390					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		AGGTTTCCACGAAGGACACCC	0.562000													31	179					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135205499	135205499	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135205499G>A	ENST00000372169.2	-	10	1668	c.1486C>T	c.(1486-1488)Cct>Tct	p.P496S	SETX_ENST00000393220.1_Missense_Mutation_p.P496S|SETX_ENST00000224140.5_Missense_Mutation_p.P496S			Q7Z333	SETX_HUMAN	senataxin	496					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCAGTGGTAGGAAGCTTGGCA	0.428000													19	91					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16272764	16272764	+	Missense_Mutation	SNP	C	C	T	rs57794451	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16272764C>T	ENST00000205557.7	-	18	2335	c.2306G>A	c.(2305-2307)aGa>aAa	p.R769K		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	769	ABC transporter 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		AGCTGCCTTTCTGTATACAGC	0.602000													17	48					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124317829	124317829	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124317829G>C	ENST00000409039.3	+	26	4385	c.4360G>C	c.(4360-4362)Ggg>Cgg	p.G1454R		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1454	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGATTTGTGGGGCCTTTTCT	0.433000													3	31					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7656797	7656797	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7656797C>G	ENST00000299492.4	+	14	1597	c.1209C>G	c.(1207-1209)aaC>aaG	p.N403K	PPFIBP2_ENST00000533792.1_Missense_Mutation_p.N245K|PPFIBP2_ENST00000530181.1_Missense_Mutation_p.N260K|PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000528883.1_Missense_Mutation_p.N291K	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	403					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGGATGGGAACCAGCCCTTCC	0.418000													14	87					0	0	1	0	0
TRIM22	10346	broad.mit.edu	37	11	5730827	5730827	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5730827C>T	ENST00000379965.3	+	8	1723	c.1446C>T	c.(1444-1446)ttC>ttT	p.F482F	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	482	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		ATCCGTATTTCAATCCTTGGA	0.483000													35	178					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56954746	56954746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56954746C>T	ENST00000497933.1	+	2	965	c.818C>T	c.(817-819)cCt>cTt	p.P273L		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	243						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						TGCCGGGGCCCTCCTGAAGTC	0.592000													37	127					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46060385	46060385	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46060385C>T	ENST00000295452.4	-	7	932	c.763_splice	c.e7-1	p.G255_splice		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	255					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TAACATAATCCCCTGTAAGAA	0.279000													22	54					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21546459	21546459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21546459C>T	ENST00000415912.2	-	19	2379	c.2254G>A	c.(2254-2256)Gaa>Aaa	p.E752K	ECE1_ENST00000374893.6_Missense_Mutation_p.E768K|ECE1_ENST00000436918.2_Missense_Mutation_p.E736K|ECE1_ENST00000264205.6_Missense_Mutation_p.E765K|ECE1_ENST00000357071.4_Missense_Mutation_p.E756K	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	768					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TACCAGACTTCGCACTTGTGA	0.617000													23	54					0	0	1	0	0
ATP5S	27109	broad.mit.edu	37	14	50789441	50789441	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:50789441A>T	ENST00000426751.2	+	3	1002	c.365A>T	c.(364-366)aAc>aTc	p.N122I	ATP5S_ENST00000554438.1_Intron|ATP5S_ENST00000358473.1_Intron|ATP5S_ENST00000245448.6_Intron|ATP5S_ENST00000311459.7_Intron	NM_015684.3	NP_056499.2	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)	0					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			breast(2)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)|stomach(1)	12	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)		CACATGGGTAACTACCCTATC	0.433000													6	65					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28233854	28233854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28233854G>A	ENST00000305242.5	-	11	1516	c.1424C>T	c.(1423-1425)tCa>tTa	p.S475L	ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000537576.1_Missense_Mutation_p.S167L|ARMC4_ENST00000545014.1_5'UTR	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	475							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						ATCCCTCATTGAACACAACGC	0.448000													42	82					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138738312	138738312	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138738312C>T	ENST00000242351.5	-	12	2650	c.2334G>A	c.(2332-2334)atG>atA	p.M778I	ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.M900I	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	778	PARP catalytic.				response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						CTTCTTCCTTCATCTGCGATT	0.388000													30	98					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	132888043	132888043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:132888043C>T	ENST00000370818.3	-	3	943	c.498G>A	c.(496-498)atG>atA	p.M166I	GPC3_ENST00000394299.2_Missense_Mutation_p.M166I|GPC3_ENST00000543339.1_Missense_Mutation_p.M112I	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	166						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					ATTCATTGACCATGTCATCTA	0.458000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				84	56					0	0	1	0	0
OR1K1	392392	broad.mit.edu	37	9	125562841	125562841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125562841G>A	ENST00000277309.2	+	1	472	c.440G>A	c.(439-441)gGa>gAa	p.G147E		NM_080859.1	NP_543135.1	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K, member 1	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(8)|lung(2)|ovary(1)|skin(4)|stomach(1)	17						GCCCTGGTGGGAATGGCATGG	0.617000													23	63					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179609144	179609144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179609144G>A	ENST00000444136.1	+	10	1941	c.1691G>A	c.(1690-1692)gGa>gAa	p.G564E	TDRD5_ENST00000367614.1_Missense_Mutation_p.G564E|TDRD5_ENST00000294848.8_Missense_Mutation_p.G564E	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	564	Tudor.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CCAGACTTTGGAAATATTGGA	0.393000													62	170					0	0	1	0	0
PNLDC1	154197	broad.mit.edu	37	6	160240299	160240299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160240299C>T	ENST00000275275.5	+	18	1585	c.1414C>T	c.(1414-1416)Ctg>Ttg	p.L472L	PNLDC1_ENST00000392167.3_Silent_p.L483L	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1	472						integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		GCGGAACATCCTGAAGGAGTA	0.602000													17	24					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242383335	242383335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:242383335G>A	ENST00000442594.2	-	6	923	c.414C>T	c.(412-414)caC>caT	p.H138H	PLD5_ENST00000536534.1_Silent_p.H230H|PLD5_ENST00000427495.1_Silent_p.H168H	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	230						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CGATATACACGTGCTGTTTGT	0.527000													16	49					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78071053	78071053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78071053G>A	ENST00000397545.4	+	19	3058	c.3031G>A	c.(3031-3033)Gag>Aag	p.E1011K		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1011					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GGCCACCGATGAGTGCACCAA	0.572000													20	80					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66067164	66067164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:66067164C>T	ENST00000349533.6	+	9	1269	c.1084C>T	c.(1084-1086)Ccc>Tcc	p.P362S	LEPR_ENST00000371058.1_Missense_Mutation_p.P362S|LEPR_ENST00000344610.8_Missense_Mutation_p.P362S|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371060.3_Missense_Mutation_p.P362S|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000371059.3_Missense_Mutation_p.P362S	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	362	Ig-like.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CAAGATTGTTCCCTCAAAAGA	0.348000													10	79					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123797160	123797160	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123797160A>C	ENST00000223642.1	-	5	534	c.505T>G	c.(505-507)Tca>Gca	p.S169A		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	169					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCAACTTCTGATCCTTCAGGA	0.299000													6	29					0	0	1	0	0
TM6SF1	53346	broad.mit.edu	37	15	83781639	83781639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83781639C>T	ENST00000322019.9	+	2	457	c.183C>T	c.(181-183)gaC>gaT	p.D61D	TM6SF1_ENST00000379386.4_Silent_p.D61D|TM6SF1_ENST00000564988.1_3'UTR|TM6SF1_ENST00000379390.6_Silent_p.D61D|TM6SF1_ENST00000565774.1_Silent_p.D61D			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	61						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						CACCCCGGGACCCACTGTTCT	0.478000													23	143					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12845054	12845054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12845054G>A	ENST00000456430.2	+	2	177	c.136G>A	c.(136-138)Gag>Aag	p.E46K	CAND2_ENST00000295989.5_Missense_Mutation_p.E46K	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	46					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CGAGGACAGCGAGCGCAAGGT	0.602000													10	52					0	0	1	0	0
ZDHHC3	51304	broad.mit.edu	37	3	44974644	44974644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44974644G>A	ENST00000296127.3	-	5	849	c.576C>T	c.(574-576)ttC>ttT	p.F192F	ZDHHC3_ENST00000342790.4_Silent_p.F226F|ZDHHC3_ENST00000424952.2_Silent_p.F192F	NM_016598.2	NP_057682.1	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3	192						Golgi membrane|integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		GCAGGAAGTGGAATCCCACCA	0.522000													19	71					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12300456	12300456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:12300456G>A	ENST00000261349.4	-	15	3317	c.3241C>T	c.(3241-3243)Cct>Tct	p.P1081S	LRP6_ENST00000543091.1_Missense_Mutation_p.P1081S	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	1081	Beta-propeller 4.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				TCAATTTTAGGAGACCTTTCC	0.408000													47	160					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94697645	94697645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94697645G>A	ENST00000304338.3	+	5	663	c.509G>A	c.(508-510)cGg>cAg	p.R170Q		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	170						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GAAACCCTACGGCATGAGGTA	0.338000													33	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575520	179575520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179575520C>T	ENST00000589042.1	-	98	28528	c.28304G>A	c.(28303-28305)aGa>aAa	p.R9435K	TTN_ENST00000342992.6_Missense_Mutation_p.R8191K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R9118K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9118	Ig-like 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCGTATTTCTCTGCTGTCTTT	0.507000													20	70					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8651042	8651042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8651042C>T	ENST00000270328.4	-	21	2890	c.2624G>A	c.(2623-2625)aGg>aAg	p.R875K	ADAMTS10_ENST00000595838.1_Missense_Mutation_p.R362K|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.R875K			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	875	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GGCGCGCTGCCTTTTGGGCAG	0.662000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	28					0	0	1	0	0
C22orf29	79680	broad.mit.edu	37	22	19838896	19838896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19838896G>A	ENST00000405640.1	-	2	1557	c.889C>T	c.(889-891)Ccc>Tcc	p.P297S	C22orf29_ENST00000407472.1_Missense_Mutation_p.P297S|GNB1L_ENST00000329517.6_Intron|C22orf29_ENST00000328554.4_Missense_Mutation_p.P297S|GNB1L_ENST00000405009.1_Intron|GNB1L_ENST00000460402.1_Intron|C22orf29_ENST00000484072.1_Intron|GNB1L_ENST00000403325.1_Intron			Q7L3V2	CV029_HUMAN	chromosome 22 open reading frame 29	297	Pro-rich.									NS(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	7	Colorectal(54;0.0993)					ACAGGTGTGGGGGCTGCCTCC	0.612000													22	37					0	0	1	0	0
CXCL12	6387	broad.mit.edu	37	10	44871439	44871439	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:44871439C>T	ENST00000374426.2	-	4	345	c.308G>A	c.(307-309)gGa>gAa	p.G103E	CXCL12_ENST00000395795.4_Intron|CXCL12_ENST00000395793.3_Intron|CXCL12_ENST00000374429.2_Intron	NM_001033886.2	NP_001029058.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	0					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	CTTCTTTTTTCCTATCTTTTC	0.408000													31	103					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70255709	70255709	+	Silent	SNP	C	C	T	rs149150723		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:70255709C>T	ENST00000342771.4	+	19	3828	c.3507C>T	c.(3505-3507)tcC>tcT	p.S1169S	AUTS2_ENST00000406775.2_Silent_p.S1145S	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	1169	His-rich.									breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GGCTCCACTCCGTGCACCCCG	0.701000													15	56					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43907535	43907535	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43907535C>T	ENST00000314537.5	+	6	735	c.510C>T	c.(508-510)ttC>ttT	p.F170F	CRHR1_ENST00000398285.3_Silent_p.F199F|CRHR1_ENST00000352855.5_Silent_p.F130F|CRHR1_ENST00000293493.7_5'UTR|CRHR1_ENST00000339069.5_Silent_p.F69F|CRHR1_ENST00000577353.1_Silent_p.F170F	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	199					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		CCACCTGGTTCGTGGTCCAGC	0.632000													25	34					0	0	1	0	0
PSPN	5623	broad.mit.edu	37	19	6375600	6375600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6375600C>T	ENST00000245810.1	-	2	175	c.176G>A	c.(175-177)cGc>cAc	p.R59H	PSPN_ENST00000597721.1_Silent_p.A87A	NM_004158.2	NP_004149.1	O60542	PSPN_HUMAN	persephin	59					axon guidance|central nervous system development		growth factor activity			lung(1)|ovary(1)|skin(1)	3						CAGGGCTCGGCGCAGGCGGGC	0.662000													5	11					0	0	1	0	0
TATDN2	9797	broad.mit.edu	37	3	10291178	10291178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10291178C>T	ENST00000287652.4	+	2	1345	c.294C>T	c.(292-294)tcC>tcT	p.S98S	TATDN2_ENST00000448281.2_Silent_p.S98S|RP11-438J1.1_ENST00000450534.1_Silent_p.S41S	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	98						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						GGGCCGCCTCCAAAGGCTGCC	0.612000													60	174					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54305292	54305292	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54305292G>A	ENST00000545554.1	+	1	192	c.192G>A	c.(190-192)aaG>aaA	p.K64K	UNC13C_ENST00000537900.1_Silent_p.K64K|UNC13C_ENST00000260323.11_Silent_p.K64K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	64					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCACTGTAAAGAAGATTGCAA	0.423000													12	56					0	0	1	0	0
CXorf67	340602	broad.mit.edu	37	X	51150631	51150631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:51150631C>T	ENST00000342995.2	+	1	865	c.763C>T	c.(763-765)Cct>Tct	p.P255S						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						TCATCTAGACCCTGCTCGTCT	0.682000													10	6					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	13984545	13984545	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:13984545G>A	ENST00000310358.7	+	0	632							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		CTTCTCCGACGAGACCCTGGA	0.711000													4	4					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87069667	87069667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87069667C>T	ENST00000265723.4	-	13	1519	c.1408G>A	c.(1408-1410)Gaa>Aaa	p.E470K	ABCB4_ENST00000358400.3_Missense_Mutation_p.E470K|ABCB4_ENST00000545634.1_Missense_Mutation_p.E470K|ABCB4_ENST00000359206.3_Missense_Mutation_p.E470K|ABCB4_ENST00000453593.1_Missense_Mutation_p.E470K	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	470	ABC transporter 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CCAATGATTTCCCTCAGATAG	0.358000													28	50					0	0	1	0	0
ELMOD1	55531	broad.mit.edu	37	11	107506466	107506466	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:107506466C>T	ENST00000265840.7	+	6	660	c.395C>T	c.(394-396)cCc>cTc	p.P132L	ELMOD1_ENST00000531234.1_Missense_Mutation_p.P126L|ELMOD1_ENST00000443271.2_Missense_Mutation_p.P132L	NM_018712.3	NP_061182.3	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1	132					phagocytosis	cytoskeleton	GTPase activator activity			endometrium(2)|large_intestine(5)|liver(2)|lung(7)|pancreas(2)|prostate(1)	19		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		TCTGATAATCCCCAACATGAA	0.458000													9	32					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241494457	241494457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241494457G>A	ENST00000401804.1	-	3	300	c.162C>T	c.(160-162)gcC>gcT	p.A54A	ANKMY1_ENST00000373318.2_Silent_p.A54A|ANKMY1_ENST00000405002.1_5'UTR|ANKMY1_ENST00000406958.1_Silent_p.A54A|ANKMY1_ENST00000361678.4_Silent_p.A54A|ANKMY1_ENST00000403283.1_Silent_p.A133A|ANKMY1_ENST00000462004.1_5'UTR|ANKMY1_ENST00000391987.1_5'UTR|ANKMY1_ENST00000536462.1_Silent_p.A7A|ANKMY1_ENST00000373320.4_5'UTR|ANKMY1_ENST00000405523.3_Silent_p.A54A|ANKMY1_ENST00000272972.3_5'UTR			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	0							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CCTTCTCAGGGGCTGCTGAAA	0.602000													56	77					0	0	1	0	0
RPN2	6185	broad.mit.edu	37	20	35860728	35860728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35860728C>T	ENST00000237530.6	+	14	1922	c.1611C>T	c.(1609-1611)ccC>ccT	p.P537P	RPN2_ENST00000470352.1_Intron|RPN2_ENST00000373622.5_Silent_p.P505P	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	537					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				AGAAGAGGCCCCCCACCGTGG	0.572000													39	179					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30507767	30507767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30507767G>A	ENST00000356798.6	+	15	1892	c.1712G>A	c.(1711-1713)gGg>gAg	p.G571E	ITGAL_ENST00000358164.5_Missense_Mutation_p.G488E|ITGAL_ENST00000433423.2_Intron	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	571					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CGGATAGAAGGGACCCAAGTG	0.577000													13	129					0	0	1	0	0
ARMC9	80210	broad.mit.edu	37	2	232127033	232127033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:232127033C>T	ENST00000349938.4	+	12	1235	c.1041C>T	c.(1039-1041)tcC>tcT	p.S347S	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	347							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TGACCACATCCCATCCTGGAG	0.478000													32	115					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189873680	189873680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189873680C>T	ENST00000304636.3	+	48	3726	c.3556C>T	c.(3556-3558)Cct>Tct	p.P1186S	COL3A1_ENST00000317840.5_Missense_Mutation_p.P883S	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1186	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GCAACCAGGCCCTCCTGGACC	0.557000													25	90					0	0	1	0	0
NHSL2	340527	broad.mit.edu	37	X	71360216	71360216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:71360216G>A	ENST00000373677.1	+	2	2982	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	NHSL2_ENST00000510661.1_Missense_Mutation_p.E709K|NHSL2_ENST00000540800.1_Missense_Mutation_p.E940K|NHSL2_ENST00000535692.1_Missense_Mutation_p.E574K			F5H593	F5H593_HUMAN	NHS-like 2	940										NS(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(10)|lung(7)|stomach(1)	28	Renal(35;0.156)					AAGCCCAGGGGAGTCAACAGC	0.542000													18	12					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2595311	2595311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2595311C>T	ENST00000399655.1	+	6	1064	c.799C>T	c.(799-801)Ccc>Tcc	p.P267S	CACNA1C_ENST00000399637.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000480911.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000335762.5_Missense_Mutation_p.P267S|CACNA1C_ENST00000399603.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399649.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399595.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399606.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399601.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399617.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000344100.3_Missense_Mutation_p.P267S|CACNA1C_ENST00000399621.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399629.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000327702.7_Missense_Mutation_p.P267S|CACNA1C_ENST00000406454.3_Missense_Mutation_p.P267S|CACNA1C_ENST00000402845.3_Missense_Mutation_p.P267S|CACNA1C_ENST00000399597.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000347598.4_Missense_Mutation_p.P267S|CACNA1C_ENST00000399641.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399638.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399644.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399591.1_Missense_Mutation_p.P267S|CACNA1C_ENST00000399634.1_Missense_Mutation_p.P267S	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	267					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGCCATGGTCCCCCTGCTGCA	0.562000													5	21					0	0	1	0	0
OGT	8473	broad.mit.edu	37	X	70787583	70787583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70787583C>T	ENST00000373719.3	+	20	3040	c.2823C>T	c.(2821-2823)acC>acT	p.T941T	OGT_ENST00000373701.3_Silent_p.T931T	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	941					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					GGGCAGGGACCCCCATGGTGA	0.507000													13	10					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15565261	15565261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15565261G>A	ENST00000343625.6	-	13	2151	c.2071C>T	c.(2071-2073)Ccc>Tcc	p.P691S		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	691					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						TAACCACTGGGGGCAGCATCC	0.557000											OREG0025322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	38					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53741697	53741697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53741697C>T	ENST00000333952.4	-	5	448	c.283G>A	c.(283-285)Gac>Aac	p.D95N	ZNF677_ENST00000598513.1_Missense_Mutation_p.D95N			Q86XU0	ZN677_HUMAN	zinc finger protein 677	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.D95N(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		TCCTTGAGGTCAAAATTGTTG	0.353000													29	122					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84530438	84530438	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84530438C>T	ENST00000527857.1	+	0	460					NR_026851.1																						CGACTGCTGTCTTGGGAGTCC	0.532000													4	41					0	0	1	0	0
TUBA3E	112714	broad.mit.edu	37	2	130952776	130952776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130952776C>T	ENST00000312988.7	-	3	351	c.251G>A	c.(250-252)aGg>aAg	p.R84K		NM_207312.2	NP_997195.1	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	84					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					GAAGAGCTGCCTGTAGGTCCC	0.507000													42	149					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128840353	128840353	+	Silent	SNP	G	G	A	rs150340160		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128840353G>A	ENST00000310343.9	-	22	4712	c.4713C>T	c.(4711-4713)ccC>ccT	p.P1571P	ARHGAP32_ENST00000527272.1_Silent_p.P1222P|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000392657.3_Silent_p.P1222P	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1571	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GAATGTCTTCGGGGTAACAGG	0.547000													18	45					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39247057	39247057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:39247057C>T	ENST00000518318.2	+	4	391	c.349C>T	c.(349-351)Ctc>Ttc	p.L117F	POU6F2_ENST00000559001.1_Missense_Mutation_p.L109F|POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_Missense_Mutation_p.L117F			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	117					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						CCCCCCAGCCCTCAACCAGCC	0.577000													58	156					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117250683	117250683	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117250683C>T	ENST00000003084.6	+	19	3231	c.3099C>T	c.(3097-3099)ttC>ttT	p.F1033F	CFTR_ENST00000454343.1_Silent_p.F972F|AC000111.6_ENST00000456270.1_RNA	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1033	ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GAGCATATTTCCTCCAAACCT	0.388000									Cystic Fibrosis				6	65					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205308499	205308499	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205308499C>T	ENST00000367156.3	-	7	1396	c.580G>A	c.(580-582)Gtc>Atc	p.V194I	KLHDC8A_ENST00000539253.1_Missense_Mutation_p.V194I|KLHDC8A_ENST00000537168.1_Missense_Mutation_p.V81I|KLHDC8A_ENST00000460687.1_Missense_Mutation_p.V60I|KLHDC8A_ENST00000367155.3_Missense_Mutation_p.V194I	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	194										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ATGTCAAAGACCTCGAAAGCG	0.567000													5	29					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170062006	170062006	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170062006G>A	ENST00000263816.3	-	41	7983	c.7698C>T	c.(7696-7698)taC>taT	p.Y2566Y		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2566					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CATCCACCCAGTAGAGAAGGT	0.483000													20	95					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073721	9073721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9073721C>T	ENST00000397910.4	-	3	13928	c.13725G>A	c.(13723-13725)ggG>ggA	p.G4575G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4577	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAAGAGCGTCCCCCATGCTGG	0.532000													15	45					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7621837	7621837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7621837G>A	ENST00000256861.6	-	9	1377	c.1299C>T	c.(1297-1299)atC>atT	p.I433I	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Silent_p.I433I|ITIH5_ENST00000298441.6_Silent_p.I219I|ITIH5_ENST00000446830.2_Silent_p.I215I|ITIH5_ENST00000397145.2_Silent_p.I433I	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	433	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CAATGGTGAAGATGCAGACTT	0.617000													27	67					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45670725	45670725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45670725C>T	ENST00000270172.3	-	10	1360	c.877G>A	c.(877-879)Gaa>Aaa	p.E293K	DNMT3L_ENST00000418993.1_Missense_Mutation_p.E293K|AP001059.5_ENST00000442785.1_RNA	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	293					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		TCCAGGTCTTCCTTGTTCAGC	0.642000													19	69					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100813667	100813667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100813667C>T	ENST00000323346.5	+	12	1813	c.1500C>T	c.(1498-1500)gtC>gtT	p.V500V	SLC17A8_ENST00000552697.1_3'UTR|SLC17A8_ENST00000392989.3_Silent_p.V450V	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	500					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TCTATGGGGTCTTTGCTTCTG	0.463000													27	69					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13919431	13919431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13919431C>T	ENST00000265104.4	-	7	933	c.829G>A	c.(829-831)Gaa>Aaa	p.E277K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	277	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCATCCGCTTCCTTCAGCAGC	0.483000									Kartagener syndrome				23	274					0	0	1	0	0
PSKH1	5681	broad.mit.edu	37	16	67942812	67942812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67942812G>A	ENST00000291041.5	+	2	330	c.160G>A	c.(160-162)Gca>Aca	p.A54T		NM_006742.2	NP_006733.1	P11801	KPSH1_HUMAN	protein serine kinase H1	54						endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|pancreas(1)	12		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)		CGGGTTCCCAGCAGCAAGTCA	0.602000													10	31					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333646	70333646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70333646C>T	ENST00000338508.4	-	32	2754	c.2755G>A	c.(2755-2757)Ggg>Agg	p.G919R	SHANK2_ENST00000449833.2_Missense_Mutation_p.G323R|SHANK2_ENST00000423696.2_Missense_Mutation_p.G539R|SHANK2_ENST00000409161.1_Missense_Mutation_p.G322R			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	539					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding	p.G919R(1)|p.G323R(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTAATCGTCCCGTAGACTCTT	0.607000													14	23					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45059290	45059290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45059290C>T	ENST00000429094.2	-	13	1925	c.1421G>A	c.(1420-1422)aGa>aAa	p.R474K	NELL2_ENST00000452445.2_Missense_Mutation_p.R474K|NELL2_ENST00000437801.2_Missense_Mutation_p.R524K|NELL2_ENST00000551601.1_Missense_Mutation_p.R473K|NELL2_ENST00000333837.4_Missense_Mutation_p.R497K|NELL2_ENST00000549027.1_Missense_Mutation_p.R473K|NELL2_ENST00000395487.2_Missense_Mutation_p.R473K	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	474	EGF-like 2; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		ATCATCAATTCTGATGTATCC	0.348000													25	38					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116931269	116931269	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116931269C>T	ENST00000356083.3	+	3	1825	c.1434C>T	c.(1432-1434)acC>acT	p.T478T		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	478	Pro-rich.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						GCACCAGCACCCACAAACCTC	0.562000													48	206					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54778665	54778665	+	Missense_Mutation	SNP	G	G	A	rs150493192	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54778665G>A	ENST00000391748.1	-	14	1793	c.1666C>T	c.(1666-1668)Ccc>Tcc	p.P556S	LILRB2_ENST00000434421.1_Missense_Mutation_p.P441S|LILRB2_ENST00000391746.1_3'UTR|LILRB2_ENST00000314446.5_Missense_Mutation_p.P556S|LILRB2_ENST00000391749.4_Missense_Mutation_p.P557S	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	557					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACATCCTGGGGGGCTTCAGAT	0.637000													29	67					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45134824	45134824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45134824G>A	ENST00000296129.1	-	6	1706	c.1572C>T	c.(1570-1572)ttC>ttT	p.F524F		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	524	CUB.					extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CCTCTTGTTGGAAGCTGGGGG	0.547000													32	74					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862802	10862802	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10862802C>T	ENST00000559480.1	+	0	98																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GTGAAGAAGCCTGGGGCCTCA	0.572000													33	197					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25308672	25308672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25308672G>A	ENST00000400358.4	+	22	2938	c.2881G>A	c.(2881-2883)Gga>Aga	p.G961R	SGSM1_ENST00000400359.4_Missense_Mutation_p.G1016R	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	1016	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						CTTCCCCCACGGAGGCGCCAT	0.512000													4	39					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16535241	16535241	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:16535241G>A	ENST00000334133.4	-	2	408	c.136C>T	c.(136-138)Ctg>Ttg	p.L46L		NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	46						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						CCAGCACTCAGAGTCGTGAAC	0.547000													70	207					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90321118	90321118	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90321118C>T	ENST00000469640.2	+	27	3582	c.3207C>T	c.(3205-3207)gtC>gtT	p.V1069V	DAPK1_ENST00000408954.3_Silent_p.V1044V|DAPK1_ENST00000358077.5_Silent_p.V1044V|DAPK1_ENST00000472284.1_Silent_p.V1044V|DAPK1_ENST00000491893.1_Silent_p.V978V			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1044					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						GCACAAACGTCCTGGGGAAGT	0.627000									Chronic Lymphocytic Leukemia, Familial Clustering of				10	40					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189526084	189526084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189526084C>T	ENST00000264731.3	+	4	437	c.348C>T	c.(346-348)ctC>ctT	p.L116L	TP63_ENST00000392460.3_Silent_p.L116L|TP63_ENST00000449992.1_Intron|TP63_ENST00000392463.2_Silent_p.L22L|TP63_ENST00000440651.2_Silent_p.L116L|TP63_ENST00000320472.5_Silent_p.L116L|TP63_ENST00000392461.3_Silent_p.L22L|TP63_ENST00000382063.4_Intron|TP63_ENST00000456148.1_Silent_p.L22L|TP63_ENST00000437221.1_Silent_p.L22L|TP63_ENST00000354600.5_Silent_p.L22L|TP63_ENST00000418709.2_Silent_p.L116L	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	116					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACCTGGGGCTCCTGAACAGCA	0.572000										HNSCC(45;0.13)			39	82					0	0	1	0	0
FAIM3	9214	broad.mit.edu	37	1	207085271	207085271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207085271C>T	ENST00000367091.3	-	4	657	c.514G>A	c.(514-516)Gtc>Atc	p.V172I	FAIM3_ENST00000442471.2_Missense_Mutation_p.V60I|FAIM3_ENST00000420007.2_Missense_Mutation_p.V172I|FAIM3_ENST00000528654.1_Intron	NM_005449.4	NP_005440.1	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3	172					anti-apoptosis|cellular defense response	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(84;0.201)					ACTGGAGGGACCTTGCCCCTT	0.542000											OREG0014185	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	30					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42204020	42204020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42204020G>A	ENST00000541110.1	-	16	3617	c.3049C>T	c.(3049-3051)Ccc>Tcc	p.P1017S	TRERF1_ENST00000354325.2_Missense_Mutation_p.P914S|TRERF1_ENST00000340840.2_Missense_Mutation_p.P914S|TRERF1_ENST00000372917.4_Missense_Mutation_p.P914S|TRERF1_ENST00000372922.4_Missense_Mutation_p.P997S			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	997	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCCTCCGTGGGAGCCAGGACG	0.627000													6	21					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133475156	133475156	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133475156C>T	ENST00000402696.3	+	6	1151	c.666C>T	c.(664-666)gcC>gcT	p.A222A	TF_ENST00000264998.3_Silent_p.A95A	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	222	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GGGATGTGGCCTTTGTCAAGC	0.517000													3	25					0	0	1	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51770657	51770657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51770657G>A	ENST00000316401.7	+	5	822	c.441G>A	c.(439-441)aaG>aaA	p.K147K	SIGLECL1_ENST00000597824.1_Silent_p.K53K|SIGLECL1_ENST00000593968.1_3'UTR|CTD-3187F8.2_ENST00000597569.1_RNA	NM_173635.1	NP_775906.1			SIGLEC family like 1																		AGCAGGCGAAGAAAGCTGCAG	0.468000													58	115					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15614330	15614330	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15614330G>A	ENST00000378076.3	-	25	2870	c.2517C>T	c.(2515-2517)atC>atT	p.I839I		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	839					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CCACCTCCAGGATGGTGTCAC	0.443000													39	92					0	0	1	0	0
CCT6B	10693	broad.mit.edu	37	17	33266229	33266229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33266229G>A	ENST00000314144.5	-	10	1301	c.1186C>T	c.(1186-1188)Cgt>Tgt	p.R396C	CCT6B_ENST00000421975.3_Missense_Mutation_p.R359C|CCT6B_ENST00000436961.3_Missense_Mutation_p.R351C	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	396					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding	p.R396C(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				TTGATAGCACGAAGTCCATCT	0.363000													61	94					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20554463	20554463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20554463G>A	ENST00000329697.6	-	11	1571	c.1403C>T	c.(1402-1404)tCc>tTc	p.S468F	ACSM2B_ENST00000565232.1_Missense_Mutation_p.S468F|ACSM2B_ENST00000565322.1_Missense_Mutation_p.S389F|ACSM2B_ENST00000567001.1_Missense_Mutation_p.S468F	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	468					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TCACCCGCTGGAGTTAATGAT	0.512000													68	385					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100686794	100686794	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100686794A>T	ENST00000306151.4	+	3	12161	c.12097A>T	c.(12097-12099)Aca>Tca	p.T4033S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4033						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TGCAACCAGTACACCTCACAC	0.527000													62	173					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45108503	45108503	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45108503C>T	ENST00000429094.2	-	10	1520	c.1016G>A	c.(1015-1017)cGa>cAa	p.R339Q	NELL2_ENST00000452445.2_Missense_Mutation_p.R339Q|NELL2_ENST00000437801.2_Missense_Mutation_p.R389Q|NELL2_ENST00000551601.1_Missense_Mutation_p.R338Q|NELL2_ENST00000333837.4_Missense_Mutation_p.R362Q|NELL2_ENST00000549027.1_Missense_Mutation_p.R338Q|NELL2_ENST00000395487.2_Missense_Mutation_p.R338Q	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	339	VWFC 2.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		AAAGTAGGTTCGTCCTTGAAA	0.348000													19	59					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71275758	71275758	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71275758G>A	ENST00000399575.2	+	3	887	c.713G>A	c.(712-714)aGt>aAt	p.S238N		NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	238					regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				GCCTTTAAAAGTTTTTGGCAA	0.368000													25	68					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905667	15905667	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15905667A>T	ENST00000308940.8	+	1	907	c.809A>T	c.(808-810)gAa>gTa	p.E270V		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CAGTCTCCGGAAGGAGACACC	0.567000													30	53					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73905021	73905021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73905021G>A	ENST00000342056.2	+	15	3138	c.2740G>A	c.(2740-2742)Gaa>Aaa	p.E914K	KCNQ5_ENST00000414165.2_Missense_Mutation_p.E785K|KCNQ5_ENST00000403813.2_Missense_Mutation_p.E886K|KCNQ5_ENST00000402622.2_Missense_Mutation_p.E905K|KCNQ5_ENST00000370398.1_Missense_Mutation_p.E895K|KCNQ5_ENST00000355635.3_Missense_Mutation_p.E896K|KCNQ5_ENST00000355194.4_Missense_Mutation_p.E895K	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	895					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GCCTGCCAGGGAAGCTGCCTT	0.507000													11	140					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71842984	71842984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:71842984C>T	ENST00000373545.3	-	18	2373	c.1935G>A	c.(1933-1935)atG>atA	p.M645I	PHKA1_ENST00000373539.3_Missense_Mutation_p.M645I|PHKA1_ENST00000339490.3_Missense_Mutation_p.M645I|PHKA1_ENST00000373542.4_Missense_Mutation_p.M645I|PHKA1_ENST00000541944.1_Missense_Mutation_p.M645I			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	645					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CATAATCATTCATCCAGTTGC	0.418000													42	28					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15753742	15753742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:15753742G>A	ENST00000285667.3	-	2	215	c.148C>T	c.(148-150)Cct>Tct	p.P50S	HSPA13_ENST00000544452.1_5'UTR|HSPA13_ENST00000478035.1_5'UTR	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	50						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						CCTGTGCCAGGAAAAAACACC	0.423000													25	58					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105763016	105763016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105763016C>T	ENST00000369755.3	+	9	2625	c.2080C>T	c.(2080-2082)Cct>Tct	p.P694S	SLK_ENST00000335753.4_Missense_Mutation_p.P694S	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	694					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TAAAAAAGAGCCTGAAGTTAC	0.368000													30	95					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961846	34961846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34961846C>T	ENST00000329357.5	+	1	934	c.898C>T	c.(898-900)Cct>Tct	p.P300S		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	300	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CCCGGAGCCTCCTGAGACTGG	0.632000													48	27					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31421725	31421725	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31421725T>C	ENST00000389202.2	+	11	1142	c.1093T>C	c.(1093-1095)Ttc>Ctc	p.F365L		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	365					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGATGGCCTCTTCCTGGGGGC	0.572000													46	86					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128432	83128432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:83128432C>T	ENST00000329312.4	+	4	753	c.716C>T	c.(715-717)tCa>tTa	p.S239L		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	239					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity	p.S238*(1)|p.S239*(1)		NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						GAGATTTGCTCAGAAAATAGT	0.333000													8	28					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26917478	26917478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:26917478G>A	ENST00000539517.2	-	5	1528	c.1211C>T	c.(1210-1212)cCc>cTc	p.P404L	NOVA1_ENST00000267422.7_Missense_Mutation_p.P282L|NOVA1_ENST00000465357.2_Missense_Mutation_p.P380L	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	407	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		GGCAGCTAGGGGAGAAGCAGC	0.502000													20	52					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289148	107289148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107289148G>A	ENST00000277216.3	-	1	342	c.343C>T	c.(343-345)Ctt>Ttt	p.L115F		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						ATCATGCCAAGGAGGAAACAT	0.438000													68	123					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003771	122003771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122003771G>A	ENST00000498619.1	+	7	3438	c.3000G>A	c.(2998-3000)agG>agA	p.R1000R	CASR_ENST00000296154.5_Silent_p.R990R|CASR_ENST00000490131.1_Silent_p.R990R	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	990					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGGCCCACAGGAATTCTACGC	0.577000													15	43					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81697756	81697756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81697756G>A	ENST00000372292.3	-	8	1020	c.980C>T	c.(979-981)cCc>cTc	p.P327L		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	327	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CTCTCCTGTGGGGTAGGTGAA	0.572000													75	196					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61978179	61978179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61978179C>T	ENST00000370263.4	-	6	2016	c.1795G>A	c.(1795-1797)Gac>Aac	p.D599N	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	599					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AAGATGCGGTCGATGACCATG	0.657000													30	59					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183721183	183721183	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183721183C>T	ENST00000511685.1	+	28	7902	c.7779C>T	c.(7777-7779)ttC>ttT	p.F2593F	TENM3_ENST00000406950.2_Silent_p.F2593F					teneurin transmembrane protein 3																		CGCGCAGGTTCGCGGACGTGG	0.692000													8	6					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109124642	109124642	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:109124642C>T	ENST00000261483.4	+	11	2820	c.1768C>T	c.(1768-1770)Cat>Tat	p.H590Y		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	590					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		CAGACTTTTTCATTCGTTAAT	0.303000													17	66					0	0	1	0	0
TBC1D16	125058	broad.mit.edu	37	17	77984429	77984429	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:77984429G>A	ENST00000310924.2	-	3	424	c.309C>T	c.(307-309)tcC>tcT	p.S103S		NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	103						intracellular	Rab GTPase activator activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			TGCGAACGGGGGAGCTCTCGG	0.701000													6	21					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53418997	53418997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:53418997C>T	ENST00000377942.3	-	3	3114	c.2911G>A	c.(2911-2913)Ggg>Agg	p.G971R	PCDH8_ENST00000338862.4_Missense_Mutation_p.G874R	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	971					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding	p.G971W(2)		breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GCGTTGGGCCCGCTGCAGGAT	0.577000													10	36					0	0	1	0	0
ZNF296	162979	broad.mit.edu	37	19	45579435	45579435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45579435G>A	ENST00000303809.2	-	1	411	c.197C>T	c.(196-198)cCc>cTc	p.P66L		NM_145288.1	NP_660331.1	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	66					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|lung(3)|prostate(1)|urinary_tract(2)	7						GGAGTGGTGGGGTTCGCCGCC	0.741000													3	17					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348302	140348302	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348302G>A	ENST00000289269.5	+	1	2483	c.1951G>A	c.(1951-1953)Gag>Aag	p.E651K	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		651	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGGGAGATGAGAGTGGTAG	0.498000													21	49					0	0	1	0	0
NECAB2	54550	broad.mit.edu	37	16	84024144	84024144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84024144C>T	ENST00000565691.1	+	4	978	c.256C>T	c.(256-258)Ctc>Ttc	p.L86F	NECAB2_ENST00000305202.4_Missense_Mutation_p.L169F			Q7Z6G3	NECA2_HUMAN	N-terminal EF-hand calcium binding protein 2	169	EF-hand 1.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19						GACCCGCTTCCTCCTGAAGGA	0.587000													26	54					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27455079	27455079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27455079C>T	ENST00000264705.4	+	17	2794	c.2632C>T	c.(2632-2634)Ctt>Ttt	p.L878F	CAD_ENST00000464159.1_3'UTR|CAD_ENST00000403525.1_Missense_Mutation_p.L815F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	878	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	ACAGATTGCCCTTGCAGTTCT	0.567000													22	79					0	0	1	0	0
CCDC81	60494	broad.mit.edu	37	11	86123537	86123537	+	Missense_Mutation	SNP	G	G	A	rs148008941	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:86123537G>A	ENST00000278487.3	+	10	1611	c.532G>A	c.(532-534)Gaa>Aaa	p.E178K	CCDC81_ENST00000528728.1_Missense_Mutation_p.E178K|CCDC81_ENST00000445632.2_Missense_Mutation_p.E443K|CCDC81_ENST00000354755.1_Missense_Mutation_p.E353K			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	443										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				ACAGGAAAACGAAATAAAGCA	0.453000													36	65					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481105	140481105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140481105C>T	ENST00000231130.2	+	1	872	c.872C>T	c.(871-873)aCt>aTt	p.T291I	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		291	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTCGCAAAACTTTTCAGCTA	0.373000													26	55					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44064780	44064780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44064780C>T	ENST00000262726.7	-	16	2039	c.1786G>A	c.(1786-1788)Gaa>Aaa	p.E596K	EFCAB6_ENST00000396231.2_Missense_Mutation_p.E444K	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TGCTGCTGTTCATCTTTTTGT	0.388000													13	134					0	0	1	0	0
TAF2	6873	broad.mit.edu	37	8	120809247	120809247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:120809247G>A	ENST00000378164.2	-	8	1372	c.1074C>T	c.(1072-1074)ttC>ttT	p.F358F		NM_003184.3	NP_003175.1	Q6P1X5	TAF2_HUMAN	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	358					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTCTAGATATGAAACAACCAA	0.383000													21	63					0	0	1	0	0
SEC23B	10483	broad.mit.edu	37	20	18529400	18529400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:18529400C>T	ENST00000336714.3	+	16	2323	c.1891C>T	c.(1891-1893)Cat>Tat	p.H631Y	SEC23B_ENST00000262544.2_Missense_Mutation_p.H631Y|SEC23B_ENST00000377465.1_Missense_Mutation_p.H631Y|SEC23B_ENST00000377475.3_Missense_Mutation_p.H631Y	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	631					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						TTACTCCTTTCATGGGCCACC	0.448000													8	72					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74460664	74460664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74460664G>A	ENST00000394019.2	-	23	2857	c.2460C>T	c.(2458-2460)ttC>ttT	p.F820F	SLC4A5_ENST00000346834.4_Silent_p.F820F|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Silent_p.F820F|SLC4A5_ENST00000377634.4_Silent_p.F820F|SLC4A5_ENST00000359484.4_Silent_p.F718F|SLC4A5_ENST00000357822.5_Silent_p.F820F|SLC4A5_ENST00000358683.4_Silent_p.F718F|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Silent_p.F820F	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	820						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGGGGGCCACGAACCAGCCTC	0.622000													11	28					0	0	1	0	0
HMGCR	3156	broad.mit.edu	37	5	74643088	74643088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:74643088C>T	ENST00000287936.4	+	6	666	c.510C>T	c.(508-510)ctC>ctT	p.L170L	HMGCR_ENST00000511206.1_Silent_p.L170L|HMGCR_ENST00000343975.5_Silent_p.L170L	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	170					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CGTTTACCCTCGATGCTCTTG	0.378000													92	225					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169116292	169116292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169116292C>T	ENST00000256935.8	+	9	878	c.798C>T	c.(796-798)ttC>ttT	p.F266F		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	266					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCGGGGCTTCCCTAAGGAGA	0.522000													17	56					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70526179	70526179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:70526179G>A	ENST00000327305.6	-	4	1008	c.351C>T	c.(349-351)ttC>ttT	p.F117F	NETO1_ENST00000397929.1_Silent_p.F116F|NETO1_ENST00000583169.1_Silent_p.F117F|NETO1_ENST00000299430.2_Silent_p.F116F|NETO1_ENST00000580049.1_5'UTR	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	117	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GTTGTCCACAGAAACGTCCAA	0.378000													28	73					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49244174	49244174	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49244174C>T	ENST00000332955.2	-	10	1591	c.1044G>A	c.(1042-1044)agG>agA	p.R348R		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	348					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TTTATTGTTGCCTCGAATCTG	0.512000													18	33					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39666958	39666958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39666958C>T	ENST00000265708.4	-	7	644	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	ADAM2_ENST00000347580.4_Intron|ADAM2_ENST00000521880.1_Missense_Mutation_p.E181K|ADAM2_ENST00000379853.2_Intron	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	181	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ACATGCATTTCTATATACTTT	0.259000													6	29					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43171060	43171060	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:43171060G>A	ENST00000522175.2	+	0	795							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GACATCAGAGGAAGAGCCACA	0.284000													17	53					0	0	1	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157267	65157267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65157267C>T	ENST00000323544.4	+	6	781	c.653C>T	c.(652-654)cCt>cTt	p.P218L	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	218	Pro-rich.									NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						ACCACCAGCCCTGGTGACAGG	0.622000													20	175					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52200089	52200089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52200089G>A	ENST00000354534.5	+	27	4997	c.4819G>A	c.(4819-4821)Gag>Aag	p.E1607K	SCN8A_ENST00000545061.1_Missense_Mutation_p.E1566K	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1607					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AGATATAATTGAGAAATACTT	0.433000													62	160					0	0	1	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940337	67940337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:67940337G>A	ENST00000357461.2	-	3	713	c.304C>T	c.(304-306)Ccc>Tcc	p.P102S	TMEM229B_ENST00000557006.1_Missense_Mutation_p.P102S	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	102						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						TAGTCCCAGGGGCAGGCGTTG	0.627000													4	8					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2297749	2297749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2297749G>A	ENST00000381458.5	+	6	768	c.705G>A	c.(703-705)ggG>ggA	p.G235G	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	235					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	TGCTTGCTGGGAATTGGAGCG	0.532000													31	110					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111394212	111394212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111394212C>T	ENST00000393934.3	+	1	690	c.120C>T	c.(118-120)ccC>ccT	p.P40P	PLCXD2_ENST00000477665.1_Silent_p.P40P	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	40					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CCTCGCTCCCCCCTCACCTCC	0.542000													35	105					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762729	24762729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24762729C>T	ENST00000376451.2	+	2	833	c.573C>T	c.(571-573)gcC>gcT	p.A191A	KIAA1217_ENST00000307544.6_Silent_p.A191A|KIAA1217_ENST00000458595.1_Silent_p.A473A|KIAA1217_ENST00000396446.1_Silent_p.A191A|KIAA1217_ENST00000430453.2_Silent_p.A394A|KIAA1217_ENST00000376462.1_Silent_p.A393A|KIAA1217_ENST00000396445.1_Silent_p.A191A|KIAA1217_ENST00000376452.3_Silent_p.A473A|KIAA1217_ENST00000376454.3_Silent_p.A473A			Q5T5P2	SKT_HUMAN	KIAA1217	473					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CACCCCCTGCCTCTCCTCACA	0.532000													38	84					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50376884	50376884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50376884G>A	ENST00000376020.2	-	4	2214	c.2189C>T	c.(2188-2190)cCa>cTa	p.P730L	SHROOM4_ENST00000289292.7_Missense_Mutation_p.P730L|SHROOM4_ENST00000460112.3_Missense_Mutation_p.P614L	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	730					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					ATTATGCTCTGGAGACCATCT	0.552000													3	21					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219294035	219294035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219294035G>A	ENST00000248444.5	+	7	683	c.595G>A	c.(595-597)Gac>Aac	p.D199N	VIL1_ENST00000440053.1_Missense_Mutation_p.D199N|VIL1_ENST00000392114.2_Intron	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	199	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGATCCGAGACCAGGAGCG	0.617000													34	76					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24197023	24197023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24197023G>A	ENST00000265769.4	+	15	1722	c.1612G>A	c.(1612-1614)Ggg>Agg	p.G538R	RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_Missense_Mutation_p.G285R|RP11-624C23.1_ENST00000519689.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	538	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		GAATGAAGGTGGGTCAAAGTA	0.458000													3	24					0	0	1	0	0
VPS51	738	broad.mit.edu	37	11	64876153	64876153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64876153C>T	ENST00000279281.3	+	5	1302	c.1210C>T	c.(1210-1212)Cgc>Tgc	p.R404C	VPS51_ENST00000527646.1_3'UTR	NM_013265.2	NP_037397.2			vacuolar protein sorting 51 homolog (S. cerevisiae)																		ACGAGTGGCCCGCGAGCGCCT	0.751000													6	6					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38596017	38596017	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38596017G>A	ENST00000413689.1	-	27	4759	c.4566C>T	c.(4564-4566)ttC>ttT	p.F1522F	SCN5A_ENST00000423572.2_Silent_p.F1521F|SCN5A_ENST00000464652.1_5'UTR|SCN5A_ENST00000425664.1_Silent_p.F1504F|SCN5A_ENST00000455624.2_Silent_p.F1521F|SCN5A_ENST00000450102.2_Silent_p.F1468F|SCN5A_ENST00000449557.2_Silent_p.F1468F|SCN5A_ENST00000414099.2_Silent_p.F1504F|SCN5A_ENST00000451551.2_Silent_p.F1468F|SCN5A_ENST00000333535.4_Silent_p.F1522F|SCN5A_ENST00000443581.1_Silent_p.F1521F	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1522					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCACAATGTCGAATATGAAGC	0.502000													44	85					0	0	1	0	0
TDRD3	81550	broad.mit.edu	37	13	61102816	61102816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:61102816C>T	ENST00000196169.3	+	11	1966	c.1178C>T	c.(1177-1179)cCt>cTt	p.P393L	TDRD3_ENST00000377894.2_Missense_Mutation_p.P393L|TDRD3_ENST00000535286.1_Missense_Mutation_p.P486L|TDRD3_ENST00000377881.2_Missense_Mutation_p.P393L	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	393					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		ACTTCATATCCTTTAGGTTCT	0.373000													23	91					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57535160	57535160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57535160C>T	ENST00000243077.3	+	3	660	c.194C>T	c.(193-195)cCa>cTa	p.P65L	LRP1_ENST00000338962.4_Missense_Mutation_p.P65L|LRP1_ENST00000554174.1_Missense_Mutation_p.P65L|LRP1_ENST00000553277.1_Missense_Mutation_p.P65L	NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	65	LDL-receptor class A 1.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCTCAGGTCCACAGAGTAAG	0.577000													14	38					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20434538	20434538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20434538C>T	ENST00000222573.3	+	8	1760	c.1076C>T	c.(1075-1077)cCa>cTa	p.P359L	ITGB8_ENST00000537992.1_Missense_Mutation_p.P224L	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	359	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						CCCCTCTTGCCAGGCACCATT	0.328000													8	63					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40251444	40251444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:40251444G>A	ENST00000302541.6	+	11	2107	c.1765G>A	c.(1765-1767)Gag>Aag	p.E589K	MYRIP_ENST00000539167.1_Missense_Mutation_p.E402K|MYRIP_ENST00000444716.1_Missense_Mutation_p.E589K|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Missense_Mutation_p.E500K|MYRIP_ENST00000425621.1_Missense_Mutation_p.E589K	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	589	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CAGGCTGTACGAGTTAGCAAT	0.493000													32	72					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41316121	41316121	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41316121C>T	ENST00000551295.2	+	5	408	c.291C>T	c.(289-291)aaC>aaT	p.N97N	CNTN1_ENST00000360099.3_Silent_p.N97N|CNTN1_ENST00000547702.1_Silent_p.N97N|CNTN1_ENST00000347616.1_Silent_p.N97N|CNTN1_ENST00000348761.2_Silent_p.N86N|CNTN1_ENST00000547849.1_Silent_p.N97N	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	97	Ig-like C2-type 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TAGGAGGAAACCTTGTTATCA	0.408000													17	74					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50976922	50976922	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:50976922G>A	ENST00000442544.2	+	23	3898	c.3282G>A	c.(3280-3282)aaG>aaA	p.K1094K	DCC_ENST00000581580.1_Silent_p.K729K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1094					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTCCTCAGAAGAACAGCAACC	0.532000													28	56					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55224589	55224589	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55224589C>T	ENST00000413439.1	+	0	1769																											CTTGGTCCACCATCCCCAGCC	0.612000													12	37					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41689911	41689911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41689911C>T	ENST00000313860.7	+	24	3045	c.2991C>T	c.(2989-2991)acC>acT	p.T997T	LIMCH1_ENST00000381753.4_Intron|LIMCH1_ENST00000513024.1_Intron|LIMCH1_ENST00000508501.1_Intron|LIMCH1_ENST00000512946.1_Intron|LIMCH1_ENST00000509277.1_Silent_p.T830T|LIMCH1_ENST00000511496.1_Intron|LIMCH1_ENST00000512820.1_Intron|LIMCH1_ENST00000503057.1_Silent_p.T1381T|LIMCH1_ENST00000512632.1_Intron|LIMCH1_ENST00000514096.1_Intron|LIMCH1_ENST00000396595.3_Intron	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	997					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						GTTCTCCCACCCCTCCCGGTC	0.483000													24	82					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144359486	144359486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:144359486C>T	ENST00000262995.4	+	4	1355	c.928C>T	c.(928-930)Cct>Tct	p.P310S	GAB1_ENST00000505913.1_Missense_Mutation_p.P207S|GAB1_ENST00000262994.4_Missense_Mutation_p.P310S	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	310					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					TTATGACATTCCTCCAACACC	0.413000													31	84					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125281525	125281525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125281525C>T	ENST00000340750.1	+	1	106	c.106C>T	c.(106-108)Ctg>Ttg	p.L36L		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						GGGCATGTACCTGATCACGGT	0.572000													32	167					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16878368	16878368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:16878368G>A	ENST00000377833.4	-	63	10111	c.10046C>T	c.(10045-10047)tCa>tTa	p.S3349L		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3349	CUB 25.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTGAAATCTTGAATTTCCGTG	0.378000													28	83					0	0	1	0	0
TEX37	200523	broad.mit.edu	37	2	88825180	88825180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:88825180C>T	ENST00000303254.3	+	2	160	c.18C>T	c.(16-18)taC>taT	p.Y6Y		NM_152670.2	NP_689883.1			testis expressed 37																		GTGTGAAATACCCGGGACAGG	0.547000													59	155					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7751449	7751449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7751449C>T	ENST00000254846.5	+	11	2232	c.1843C>T	c.(1843-1845)Cac>Tac	p.H615Y	KDM6B_ENST00000448097.2_Missense_Mutation_p.H615Y	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	615	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						TTCCTCCTGCCACCAAAATAC	0.697000													48	53					0	0	1	0	0
VWA1	64856	broad.mit.edu	37	1	1374645	1374645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1374645C>T	ENST00000476993.1	+	3	894	c.816C>T	c.(814-816)ggC>ggT	p.G272G	VWA1_ENST00000338660.5_3'UTR|VWA1_ENST00000404702.3_Silent_p.G60G	NM_022834.4	NP_073745.2	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	272	Fibronectin type-III 1.					basement membrane				NS(1)|breast(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCTGGGCCGGCCTCGACCCGG	0.706000													5	18					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998538	27998538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27998538G>A	ENST00000441525.1	-	1	1028	c.914C>T	c.(913-915)tCa>tTa	p.S305L		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	305										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						ATCTTCACCTGAAGTGAGGAA	0.483000													21	25					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90177088	90177088	+	Silent	SNP	C	C	T	rs141497185		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90177088C>T	ENST00000394412.3	-	12	2497	c.2421G>A	c.(2419-2421)acG>acA	p.T807T		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	807					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CCAGCCGCTCCGTAGCCTGCT	0.637000													14	78					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105769081	105769081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:105769081G>A	ENST00000393127.2	+	7	1259	c.813G>A	c.(811-813)atG>atA	p.M271I	GRIA4_ENST00000428631.2_Missense_Mutation_p.M271I|GRIA4_ENST00000525187.1_Missense_Mutation_p.M271I|GRIA4_ENST00000282499.5_Missense_Mutation_p.M271I|GRIA4_ENST00000530497.1_Missense_Mutation_p.M271I|GRIA4_ENST00000393125.2_Missense_Mutation_p.M271I	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	271					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATACACCTATGGTAATCAAAC	0.353000													21	54					0	0	1	0	0
DYRK4	8798	broad.mit.edu	37	12	4705365	4705365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4705365G>A	ENST00000540757.2	+	5	493	c.333G>A	c.(331-333)ggG>ggA	p.G111G	DYRK4_ENST00000010132.5_Silent_p.G111G|DYRK4_ENST00000543431.1_Silent_p.G111G	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	111	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			AGACAATCGGGAAGGGGTCCT	0.547000													55	96					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13418631	13418631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13418631C>T	ENST00000360228.5	-	15	1950	c.1951G>A	c.(1951-1953)Gat>Aat	p.D651N	CACNA1A_ENST00000573710.2_Missense_Mutation_p.D652N	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	652					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGAAAAGTATCGAAGTTGGTG	0.557000													22	84					0	0	1	0	0
TEKT4	150483	broad.mit.edu	37	2	95540699	95540699	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95540699G>A	ENST00000295201.4	+	4	1029	c.892G>A	c.(892-894)Gag>Aag	p.E298K	AC097374.2_ENST00000568768.1_RNA	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	298					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						CCGCTGTGAGGAGCTGGAGGA	0.682000													7	19					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8176141	8176141	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8176141G>A	ENST00000520004.1	-	6	4008	c.3744C>T	c.(3742-3744)ttC>ttT	p.F1248F	SGK223_ENST00000330777.4_Silent_p.F1248F			Q86YV5	SG223_HUMAN		1248	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity										GGAACTCATCGAACTTGCGGT	0.642000													19	41					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19974856	19974856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:19974856G>A	ENST00000295824.9	-	1	816	c.655C>T	c.(655-657)Ccc>Tcc	p.P219S	EFHB_ENST00000344838.4_Missense_Mutation_p.P89S|EFHB_ENST00000498089.1_5'UTR	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	219					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						TGGCATTGGGGAGGTTCTATC	0.502000													33	86					0	0	1	0	0
KRTAP10-12	386685	broad.mit.edu	37	21	46117623	46117623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46117623C>T	ENST00000400365.3	+	1	537	c.507C>T	c.(505-507)gcC>gcT	p.A169A	TSPEAR_ENST00000323084.4_Intron	NM_198699.1	NP_941972.1	P60413	KR10C_HUMAN	keratin associated protein 10-12	169	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|lung(8)	9						GCTCTGGGGCCTCCTCTCTGT	0.647000													63	275					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119737589	119737589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119737589G>A	ENST00000313400.4	-	10	1887	c.1787C>T	c.(1786-1788)cCt>cTt	p.P596L	ASTN2_ENST00000361209.2_Missense_Mutation_p.P545L|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.P592L			O75129	ASTN2_HUMAN	astrotactin 2	596						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TTTGCTGACAGGAAGCCAGAG	0.552000													15	47					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934998	28934998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28934998C>T	ENST00000257192.4	+	15	3051	c.2839C>T	c.(2839-2841)Cac>Tac	p.H947Y	DSG1_ENST00000462981.2_Missense_Mutation_p.H306Y|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	947					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding	p.H947N(1)		NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AGCCAATGCCCACAATGTCAT	0.507000													79	198					0	0	1	0	0
SYTL5	94122	broad.mit.edu	37	X	37935888	37935888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37935888G>A	ENST00000357972.5	+	6	1169	c.623G>A	c.(622-624)cGg>cAg	p.R208Q	SYTL5_ENST00000456733.2_Missense_Mutation_p.R208Q|SYTL5_ENST00000297875.2_Missense_Mutation_p.R208Q|TM4SF2_ENST00000465127.1_Intron			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	208					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						GACACTGGGCGGAGCTATAGC	0.388000													38	30					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117232120	117232120	+	Silent	SNP	C	C	T	rs121908777		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117232120C>T	ENST00000003084.6	+	14	2031	c.1899C>T	c.(1897-1899)ctC>ctT	p.L633L	CFTR_ENST00000454343.1_Silent_p.L572L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	633	ABC transporter 1.		L -> P (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTTCAGAACTCCAAAATCTAC	0.348000									Cystic Fibrosis				40	93					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16882980	16882980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:16882980G>A	ENST00000377833.4	-	61	9795	c.9730C>T	c.(9730-9732)Cct>Tct	p.P3244S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3244	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAGATAAAAGGAGCAGGTACT	0.388000													25	70					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680293	114680293	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114680293G>A	ENST00000393296.1	-	3	972	c.895C>T	c.(895-897)Cac>Tac	p.H299Y	SYT6_ENST00000369547.1_Missense_Mutation_p.H214Y			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	299	C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGGGAAGTGGAAGTTCTCA	0.557000													28	57					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4834515	4834515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:4834515C>T	ENST00000378191.4	+	5	1573	c.1192C>T	c.(1192-1194)Cct>Tct	p.P398S	AJAP1_ENST00000378190.3_Missense_Mutation_p.P398S	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	398	Targeting signals.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GCATCTTATTCCTGTGGCCTT	0.532000													12	117					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101906464	101906464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101906464C>T	ENST00000348070.1	-	14	1791	c.1792G>A	c.(1792-1794)Gaa>Aaa	p.E598K	PCSK6_ENST00000331826.7_Missense_Mutation_p.E433K|PCSK6_ENST00000398181.2_Missense_Mutation_p.E598K|PCSK6_ENST00000561177.1_5'UTR|PCSK6_ENST00000344273.2_Missense_Mutation_p.E598K|PCSK6_ENST00000358417.3_Missense_Mutation_p.E598K	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	599	Homo B/P.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CACTGCCCTTCAGCCTTTTCT	0.502000													26	26					0	0	1	0	0
GLP2R	9340	broad.mit.edu	37	17	9783763	9783763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:9783763C>T	ENST00000262441.5	+	11	1727	c.1214C>T	c.(1213-1215)aCt>aTt	p.T405I	GLP2R_ENST00000574745.1_Missense_Mutation_p.T225I	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	405					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	TCTTTCATCACTGATGATCAA	0.383000													64	93					0	0	1	0	0
AMELX	265	broad.mit.edu	37	X	11316365	11316365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:11316365C>T	ENST00000380712.3	+	5	222	c.154C>T	c.(154-156)Cct>Tct	p.P52S	ARHGAP6_ENST00000337414.4_Intron|ARHGAP6_ENST00000413512.3_Intron|AMELX_ENST00000380714.3_Missense_Mutation_p.P38S|ARHGAP6_ENST00000380732.3_Intron|AMELX_ENST00000348912.4_Missense_Mutation_p.P22S|ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000380736.1_Intron	NM_182680.1	NP_872621.1	Q99217	AMELX_HUMAN	amelogenin, X-linked	38					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel			endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						GGTGCTTACCCCTTTGAAGTG	0.353000													68	117					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16861084	16861084	+	Missense_Mutation	SNP	G	G	A	rs148029259	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16861084G>A	ENST00000524140.2	+	6	2049	c.1631G>A	c.(1630-1632)cGg>cAg	p.R544Q	NWD1_ENST00000523826.1_Missense_Mutation_p.R338Q|NWD1_ENST00000379808.3_Missense_Mutation_p.R544Q|NWD1_ENST00000339803.6_Missense_Mutation_p.R409Q|NWD1_ENST00000552788.1_Missense_Mutation_p.R544Q|NWD1_ENST00000549814.1_Missense_Mutation_p.R544Q	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	544	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAGGAAGCCCGGAAATGGGCC	0.662000													18	43					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35579437	35579437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35579437C>T	ENST00000373330.1	+	11	2180	c.2006C>T	c.(2005-2007)tCa>tTa	p.S669L	ZMYM1_ENST00000373329.1_3'UTR|ZMYM1_ENST00000359858.4_Missense_Mutation_p.S669L			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	669						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCACAAAAATCATCAAAGGCT	0.368000													21	51					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99724046	99724046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:99724046C>T	ENST00000345514.2	-	2	455	c.189G>A	c.(187-189)atG>atA	p.M63I	BCL11B_ENST00000357195.3_Missense_Mutation_p.M63I|BCL11B_ENST00000443726.2_Intron	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	0						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		AGGGGAAGTTCATTTGACACT	0.577000			T	TLX3	T-ALL								27	56					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104174648	104174648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104174648C>T	ENST00000020673.5	-	4	1622	c.1096G>A	c.(1096-1098)Gag>Aag	p.E366K	PSD_ENST00000406432.1_Missense_Mutation_p.E366K	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	366					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TCAAACACCTCGTCGTCCACA	0.657000													36	91					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10265791	10265791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10265791G>A	ENST00000418404.3	-	3	397	c.234C>T	c.(232-234)ttC>ttT	p.F78F	MYH13_ENST00000570743.1_Silent_p.F78F|MYH13_ENST00000252172.4_Silent_p.F78F			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	78	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GGTTCATGGGGAAGACCTGGT	0.483000													47	83					0	0	1	0	0
USP45	85015	broad.mit.edu	37	6	99885165	99885165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:99885165G>A	ENST00000327681.6	-	17	2803	c.2271C>T	c.(2269-2271)tcC>tcT	p.S757S	USP45_ENST00000369233.2_Silent_p.S709S|USP45_ENST00000392738.2_Silent_p.S437S|USP45_ENST00000539675.1_Silent_p.S50S|USP45_ENST00000500704.2_Silent_p.S757S	NM_001080481.1	NP_001073950.1	Q70EL2	UBP45_HUMAN	ubiquitin specific peptidase 45	757					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(2)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	22		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		ATAATTTCCTGGAGGGTGTTC	0.388000													18	62					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59190271	59190271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59190271C>T	ENST00000302040.4	-	1	178	c.156G>A	c.(154-156)atG>atA	p.M52I		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						GGTGAGAGTCCATCTTAATGA	0.488000													11	82					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594940	179594940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179594940C>T	ENST00000589042.1	-	62	18411	c.18187G>A	c.(18187-18189)Gat>Aat	p.D6063N	TTN_ENST00000342992.6_Missense_Mutation_p.D4819N|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.D5746N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5746	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGTGTCATCCTTCCAAACT	0.468000													18	25					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135073590	135073590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135073590C>T	ENST00000393229.3	+	3	1227	c.451C>T	c.(451-453)Ctg>Ttg	p.L151L	NTNG2_ENST00000360670.3_Silent_p.L151L|NTNG2_ENST00000393228.4_Silent_p.L151L|NTNG2_ENST00000372179.3_Silent_p.L151L	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	151	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		GGTCATGGTCCTGGAGAAGTC	0.652000													14	39					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56140524	56140524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56140524C>T	ENST00000319441.4	+	10	1697	c.1533C>T	c.(1531-1533)atC>atT	p.I511I	PCK1_ENST00000535860.1_3'UTR|PCK1_ENST00000543666.1_Silent_p.I194I	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	511					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			TGCCCAAGATCTTCCATGTCA	0.562000													19	58					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82940393	82940393	+	Silent	SNP	G	G	A	rs113269048	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82940393G>A	ENST00000274341.4	-	4	1414	c.564C>T	c.(562-564)atC>atT	p.I188I		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	188	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CGAAGGAGGCGATCACAGCAT	0.582000													16	45					0	0	1	0	0
VLDLR	7436	broad.mit.edu	37	9	2646354	2646354	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:2646354T>C	ENST00000382100.2	+	11	1861	c.1505T>C	c.(1504-1506)gTt>gCt	p.V502A	VLDLR_ENST00000382099.2_Missense_Mutation_p.V502A|VLDLR_ENST00000478776.1_3'UTR	NM_003383.3	NP_003374.3	P98155	VLDLR_HUMAN	very low density lipoprotein receptor	502					cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		GATGACAAGGTTGGTAGACAT	0.393000													35	45					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130832813	130832813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130832813C>T	ENST00000357462.5	-	15	2325	c.2232G>A	c.(2230-2232)atG>atA	p.M744I	POTEF_ENST00000409914.2_Missense_Mutation_p.M744I			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	744	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GCATGCCCCCCATCATGCCCT	0.622000													39	77					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17017874	17017874	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17017874G>A	ENST00000443236.1	-	30	4087	c.4056C>T	c.(4054-4056)ccC>ccT	p.P1352P		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1305						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CCATGGCCAGGGGCGCAGCAG	0.662000													8	18					0	0	1	0	0
KRT77	374454	broad.mit.edu	37	12	53097069	53097069	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53097069C>T	ENST00000341809.3	-	1	178	c.150G>A	c.(148-150)ggG>ggA	p.G50G	KRT77_ENST00000537195.1_5'UTR	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	50	Head.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TTCCATGGATCCCATATCCAC	0.547000													19	42					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68250149	68250149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:68250149G>A	ENST00000347230.4	-	21	3858	c.3720C>T	c.(3718-3720)tcC>tcT	p.S1240S	ZFYVE26_ENST00000555452.1_Silent_p.S1240S	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1240					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GGCTTTGCCGGGATGAGCAAA	0.592000													40	69					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247751996	247751996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247751996C>T	ENST00000320065.1	+	1	335	c.335C>T	c.(334-336)tCc>tTc	p.S112F	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCCCTGGGATCCACTGAGTGC	0.522000													50	129					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196801382	196801382	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196801382G>A	ENST00000312428.6	-	20	3313	c.3213C>T	c.(3211-3213)ttC>ttT	p.F1071F		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1071	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACAAAAAAAAGAATCTGGGGA	0.328000													26	53					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49362255	49362255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49362255G>A	ENST00000263265.6	-	8	1389	c.834C>T	c.(832-834)gtC>gtT	p.V278V	PLEKHA4_ENST00000355496.5_Silent_p.V278V|PLEKHA4_ENST00000596713.1_5'UTR	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	278	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GAGGAGGTCGGACATCAATGC	0.706000													11	30					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97082625	97082625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:97082625C>T	ENST00000335456.7	-	6	1208	c.1188G>A	c.(1186-1188)ggG>ggA	p.G396G	NUTM2F_ENST00000341207.4_Silent_p.G396G|NUTM2F_ENST00000253262.4_Silent_p.G411G					NUT family member 2F																		CCCCTGTGTCCCCAGGGTGAG	0.622000													11	97					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79364271	79364271	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79364271C>T	ENST00000444841.1	-	0	285																											CATCTCATATCAGCCACTGAA	0.507000													5	13					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176740250	176740250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176740250C>T	ENST00000367662.3	+	17	5813	c.4649C>T	c.(4648-4650)aCc>aTc	p.T1550I		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1550	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GACGTGGGCACCATCTGCAAA	0.488000													24	50					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125148925	125148925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125148925G>A	ENST00000362012.2	+	9	1215	c.1210G>A	c.(1210-1212)Gag>Aag	p.E404K	PTGS1_ENST00000373698.5_Missense_Mutation_p.E295K|PTGS1_ENST00000540753.1_Intron|AL162424.1_ENST00000600713.1_Missense_Mutation_p.R2C|PTGS1_ENST00000223423.4_Intron	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	404					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity	p.E404K(1)		large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	GTACAGCTACGAGCAGTTCTT	0.577000													26	106					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36035837	36035837	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36035837C>T	ENST00000282507.3	-	7	1636	c.1535G>A	c.(1534-1536)tGg>tAg	p.W512*	UGT3A2_ENST00000545528.1_Nonsense_Mutation_p.W210*|UGT3A2_ENST00000513300.1_Nonsense_Mutation_p.W478*	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	512						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACGCAGCCACCAGACAGCCAT	0.587000													14	53					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15789950	15789950	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15789950C>T	ENST00000359621.4	+	5	451	c.426C>T	c.(424-426)ctC>ctT	p.L142L		NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	142	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						TGGCCTGCCTCCCTCCTGCCG	0.627000													40	72					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53225195	53225195	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53225195C>T	ENST00000330553.5	-	2	727	c.693G>A	c.(691-693)aaG>aaA	p.K231K		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	231	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CTCACTTGTTCTTGAAGTCCT	0.642000													35	107					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220480833	220480833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220480833C>T	ENST00000456909.1	+	25	3275	c.3185C>T	c.(3184-3186)gCc>gTc	p.A1062V	STK11IP_ENST00000295641.10_Missense_Mutation_p.A1073V			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	1073					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCCTGCTTGCCTGGATCCGG	0.622000													5	24					0	0	1	0	0
FOXJ1	2302	broad.mit.edu	37	17	74133578	74133578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74133578C>T	ENST00000322957.6	-	3	1476	c.1122G>A	c.(1120-1122)gaG>gaA	p.E374E		NM_001454.3	NP_001445.2	Q92949	FOXJ1_HUMAN	forkhead box J1	374					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|liver(1)|pancreas(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(166;0.187)			CCAGGAAGGTCTCATCGAAGT	0.682000													4	3					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389662	20389662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20389662G>A	ENST00000315915.4	+	1	922	c.897G>A	c.(895-897)agG>agA	p.R299R		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGCCGTAAGGAAAATTGTGA	0.383000													46	111					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38493843	38493843	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38493843G>A	ENST00000263409.4	-	14	2092	c.1930C>T	c.(1930-1932)Ctc>Ttc	p.L644F	LIFR_ENST00000453190.2_Missense_Mutation_p.L644F|LIFR_ENST00000503088.1_5'UTR	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	644	Fibronectin type-III 5.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					CAGGTGAGGAGAATCCCCTTT	0.413000			T	PLAG1	salivary adenoma								28	84					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151400505	151400505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151400505G>A	ENST00000271715.2	-	7	1186	c.872C>T	c.(871-873)cCc>cTc	p.P291L	POGZ_ENST00000409503.1_Intron|POGZ_ENST00000491586.1_Missense_Mutation_p.P238L|POGZ_ENST00000531094.1_Intron|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000392723.1_Missense_Mutation_p.P238L|POGZ_ENST00000368863.2_Missense_Mutation_p.P196L|POGZ_ENST00000361398.3_Missense_Mutation_p.P238L	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	291					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGGTGGAGAGGGGAAGGAGGG	0.517000													21	82					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48697087	48697087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48697087C>T	ENST00000354983.4	+	32	6095	c.5723C>T	c.(5722-5724)tCc>tTc	p.S1908F	CACNA1G_ENST00000512389.1_Intron|CACNA1G_ENST00000507336.1_Missense_Mutation_p.S1931F|CACNA1G_ENST00000507609.1_Intron|CACNA1G_ENST00000503485.1_Intron|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000510115.1_Missense_Mutation_p.S1908F|CACNA1G_ENST00000352832.5_Intron|CACNA1G_ENST00000510366.1_Intron|CACNA1G_ENST00000502264.1_Intron|CACNA1G_ENST00000429973.2_Intron|CACNA1G_ENST00000360761.4_Intron|CACNA1G_ENST00000515765.1_Missense_Mutation_p.S1931F|CACNA1G_ENST00000515411.1_Missense_Mutation_p.S1924F|CACNA1G_ENST00000442258.2_Intron|CACNA1G_ENST00000515165.1_Intron|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000359106.5_Missense_Mutation_p.S1942F|CACNA1G_ENST00000514717.1_Intron|CACNA1G_ENST00000514181.1_Intron|CACNA1G_ENST00000514079.1_Intron|CACNA1G_ENST00000513964.1_Intron|CACNA1G_ENST00000507510.2_Missense_Mutation_p.S1942F|CACNA1G_ENST00000513689.2_Missense_Mutation_p.S1897F	NM_198396.2	NP_938406.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1942					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	ATCCAGGGCTCCCTGGAGTGG	0.682000													4	18					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94888394	94888394	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94888394G>A	ENST00000357742.4	+	7	1005		c.e7+1		MCTP2_ENST00000543482.1_Splice_Site|MCTP2_ENST00000451018.3_Splice_Site|MCTP2_ENST00000331706.4_Splice_Site	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TGCCAGCAAGGTAAATATACT	0.338000													8	55					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4967979	4967979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4967979G>A	ENST00000380373.2	-	1	377	c.352C>T	c.(352-354)Ctg>Ttg	p.L118L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACATGATCAGGAGGACTGAG	0.443000													48	288					0	0	1	0	0
STXBP3	6814	broad.mit.edu	37	1	109302685	109302685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109302685C>T	ENST00000370008.3	+	6	466	c.416C>T	c.(415-417)tCc>tTc	p.S139F	STXBP3_ENST00000485167.1_3'UTR	NM_007269.2	NP_009200.2	O00186	STXB3_HUMAN	syntaxin binding protein 3	139	Mediates interaction with DOC2B (By similarity).				negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(3)|urinary_tract(1)	13		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		ATAAATATTTCCTTCATTCCA	0.289000													55	148					0	0	1	0	0
MLKL	197259	broad.mit.edu	37	16	74729435	74729435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:74729435C>T	ENST00000308807.7	-	2	684	c.221G>A	c.(220-222)gGg>gAg	p.G74E	MLKL_ENST00000306247.7_Missense_Mutation_p.G74E	NM_152649.2	NP_689862.1	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like	74							ATP binding|protein binding|protein kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(6)|skin(1)|stomach(2)	19						TTCTATCTCCCCATTAGCCTC	0.498000													14	104					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70048889	70048889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70048889G>A	ENST00000330891.5	-	10	2031	c.1805C>T	c.(1804-1806)tCc>tTc	p.S602F	BEST3_ENST00000488961.1_Missense_Mutation_p.S389F|BEST3_ENST00000553096.1_Missense_Mutation_p.S496F|BEST3_ENST00000331471.4_Intron	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	602						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GTTTCCCAGGGAAGTGTGGCT	0.498000													24	37					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58149057	58149057	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58149057G>A	ENST00000295956.4	+	43	7363	c.7198_splice	c.e43+1	p.G2400_splice	FLNB_ENST00000358537.3_Splice_Site_p.G2376_splice|FLNB_ENST00000429972.2_Splice_Site_p.G2389_splice|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000490882.1_Splice_Site_p.G2431_splice|FLNB_ENST00000348383.5_Splice_Site_p.G2359_splice|FLNB-AS1_ENST00000488720.1_RNA|FLNB_ENST00000419752.2_Splice_Site_p.G2220_splice|FLNB_ENST00000493452.1_Splice_Site_p.G2207_splice	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2400	Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGGCACCACAGGTAACCCACT	0.572000													21	37					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072209	17072209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17072209C>T	ENST00000359963.3	-	1	1491	c.1232G>A	c.(1231-1233)gGa>gAa	p.G411E		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	411					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GGCCCCAGCTCCTGGAATCAG	0.562000													28	54					0	0	1	0	0
TMEM155	132332	broad.mit.edu	37	4	122682721	122682721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122682721G>A	ENST00000337677.5	-	5	742	c.184C>T	c.(184-186)Cgc>Tgc	p.R62C	TMEM155_ENST00000394394.1_Missense_Mutation_p.R62C|TMEM155_ENST00000394396.1_Missense_Mutation_p.R62C	NM_152399.2	NP_689612.2	Q4W5P6	TM155_HUMAN	transmembrane protein 155	62						extracellular region				breast(1)|lung(5)	6						CCCTGCAAGCGAACCAAAAAC	0.378000													21	59					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6639129	6639129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6639129C>T	ENST00000333172.6	+	6	2204	c.2011C>T	c.(2011-2013)Cac>Tac	p.H671Y	TAS1R1_ENST00000351136.3_Missense_Mutation_p.H417Y|TAS1R1_ENST00000328191.4_3'UTR	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	671					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TACATTCTACCACGCCTGGGT	0.517000													23	112					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875172	247875172	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247875172C>T	ENST00000302084.2	-	1	933	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E296K(1)		breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCTCTTACTTCCTTATTACGA	0.428000													61	148					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74825433	74825433	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74825433G>A	ENST00000256362.4	+	2	2188	c.1947G>A	c.(1945-1947)acG>acA	p.T649T		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	649					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TCGCTACCACGAAGTTCAAGG	0.612000													22	51					0	0	1	0	0
FOXRED1	55572	broad.mit.edu	37	11	126143269	126143269	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:126143269C>T	ENST00000263578.5	+	4	530	c.456C>T	c.(454-456)ctC>ctT	p.L152L	FOXRED1_ENST00000442061.2_5'UTR|FOXRED1_ENST00000532125.1_Silent_p.L138L|FOXRED1_ENST00000534011.1_3'UTR	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	152						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		CCCTGGACCTCCGGTTCAACC	0.557000													31	120					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2573002	2573002	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2573002C>T	ENST00000358864.1	+	8	896	c.881C>T	c.(880-882)cCt>cTt	p.P294L		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	294						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						AAGACAGTGCCTCGGGCTGAG	0.438000													17	142					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	40034005	40034005	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40034005C>T	ENST00000350221.3	-	6	865		c.e6+1		FSIP1_ENST00000559692.1_Splice_Site	NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1											NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TTTAAATATACCTTTATTGAG	0.328000													13	31					0	0	1	0	0
FILIP1L	11259	broad.mit.edu	37	3	99568383	99568383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:99568383C>T	ENST00000331335.5	-	5	2607	c.2137G>A	c.(2137-2139)Ggg>Agg	p.G713R	CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000471562.1_Missense_Mutation_p.G473R|FILIP1L_ENST00000487087.1_Missense_Mutation_p.G289R|CMSS1_ENST00000496116.1_Intron|FILIP1L_ENST00000476723.1_Intron|FILIP1L_ENST00000354552.3_Missense_Mutation_p.G713R|FILIP1L_ENST00000383694.2_Missense_Mutation_p.G473R	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	713						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						GAGAGGTGCCCTGACTTAGCT	0.408000													11	144					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703632	4703632	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4703632G>A	ENST00000396950.3	-	2	549	c.310C>T	c.(310-312)Cat>Tat	p.H104Y		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GAGAGGGCATGAATAAAGAAC	0.517000													17	46					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72005678	72005678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72005678G>A	ENST00000294053.3	-	14	1809	c.1636C>T	c.(1636-1638)Cgc>Tgc	p.R546C	CLPB_ENST00000437826.2_Missense_Mutation_p.R501C|CLPB_ENST00000538021.1_Missense_Mutation_p.R154C|CLPB_ENST00000543042.1_Missense_Mutation_p.R345C|CLPB_ENST00000340729.5_Missense_Mutation_p.R487C|CLPB_ENST00000538039.1_Missense_Mutation_p.R516C	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	546					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						AGGATAGGGCGAATCACATTC	0.468000													48	120					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120197765	120197765	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120197765G>A	ENST00000019103.5	-	13	1518	c.1251C>T	c.(1249-1251)gcC>gcT	p.A417A		NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	417					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	TGCTGAAGGAGGCCACGGGGT	0.637000													5	25					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169511239	169511239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169511239C>T	ENST00000367796.3	-	13	3305	c.3104G>A	c.(3103-3105)cGa>cAa	p.R1035Q	F5_ENST00000367797.3_Missense_Mutation_p.R1030Q			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1030	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTTCTTTTTTCGTGTCTTAAT	0.408000													114	243					0	0	1	0	0
XRN2	22803	broad.mit.edu	37	20	21314251	21314251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:21314251C>T	ENST00000377191.3	+	10	1023	c.928C>T	c.(928-930)Cgt>Tgt	p.R310C	XRN2_ENST00000539513.1_Missense_Mutation_p.R256C|XRN2_ENST00000430571.2_Missense_Mutation_p.R234C	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	310					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						TAATGTTCTTCGTGAGGTATG	0.403000													66	165					0	0	1	0	0
CIB3	117286	broad.mit.edu	37	19	16280507	16280507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16280507G>A	ENST00000269878.4	-	3	181	c.132C>T	c.(130-132)ctC>ctT	p.L44L	CIB3_ENST00000541493.1_Intron|CIB3_ENST00000379859.3_Intron	NM_054113.2	NP_473454.1	Q96Q77	CIB3_HUMAN	calcium and integrin binding family member 3	44							calcium ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16						TGGTATAGTCGAGGGGCACGA	0.587000													6	35					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93742422	93742422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:93742422C>T	ENST00000265990.6	+	18	2435	c.2127C>T	c.(2125-2127)tcC>tcT	p.S709S	BTAF1_ENST00000471217.1_3'UTR	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	709					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				CAGCTGAATCCCTGGGCCAGT	0.408000													34	84					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114292282	114292282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:114292282G>A	ENST00000393500.3	+	15	1714	c.894G>A	c.(892-894)ttG>ttA	p.L298L	FOXP2_ENST00000393498.2_Silent_p.L352L|FOXP2_ENST00000393491.3_Silent_p.L281L|FOXP2_ENST00000403559.4_Silent_p.L390L|FOXP2_ENST00000360232.4_Silent_p.L373L|FOXP2_ENST00000408937.3_Silent_p.L398L|FOXP2_ENST00000393494.2_Silent_p.L373L|FOXP2_ENST00000393489.3_Silent_p.L281L|FOXP2_ENST00000350908.4_Silent_p.L373L|FOXP2_ENST00000390668.3_Silent_p.L397L			O15409	FOXP2_HUMAN	forkhead box P2	373				DLTTNNSSSTTSSNT -> EEFPVQGPAAVCAGL (in Ref. 10; AAB91439).	camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						AACACGCATTGGATGACCGAA	0.408000													11	59					0	0	1	0	0
TOP1MT	116447	broad.mit.edu	37	8	144416946	144416946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144416946G>A	ENST00000329245.4	-	1	120	c.86C>T	c.(85-87)cCg>cTg	p.P29L	TOP1MT_ENST00000521193.1_Intron|TOP1MT_ENST00000523676.1_5'UTR|TOP1MT_ENST00000519148.1_Intron	NM_052963.2	NP_443195.1	Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	29					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	GCGCGAGCCCGGGACACCCCG	0.741000													8	33					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24171030	24171030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24171030G>A	ENST00000265769.4	+	6	623	c.513G>A	c.(511-513)atG>atA	p.M171I	ADAM28_ENST00000540823.1_Intron|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Missense_Mutation_p.M171I|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	171					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CCTGTGGGATGGATGGTGTGT	0.433000													39	142					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79343150	79343150	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79343150C>T	ENST00000264895.6	+	34	5114	c.4674C>T	c.(4672-4674)ttC>ttT	p.F1558F	FRAS1_ENST00000325942.6_Silent_p.F1558F	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1557					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CCTTCTCGTTCGCTGGTAATG	0.567000													51	124					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107034	121107034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:121107034G>A	ENST00000295228.3	+	2	854	c.808G>A	c.(808-810)Gag>Aag	p.E270K		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	270					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				CCCAGGCGAAGAGTCGCACCG	0.672000													36	81					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414089	20414089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:20414089G>A	ENST00000380338.4	-	5	1041	c.755C>T	c.(754-756)gCc>gTc	p.A252V	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Missense_Mutation_p.A249V	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TTCCTTGAAGGCCATCTTAGG	0.403000			T	MLL	ALL								108	211					0	0	1	0	0
PA2G4	5036	broad.mit.edu	37	12	56504387	56504387	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56504387C>T	ENST00000303305.6	+	9	1172	c.753C>T	c.(751-753)ccC>ccT	p.P251P	RP11-603J24.17_ENST00000548595.1_RNA|PA2G4_ENST00000552766.1_Silent_p.P251P	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	251					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			AACGAGACCCCTCTAAACAGT	0.433000													29	66					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51981872	51981872	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51981872C>T	ENST00000451626.1	+	2	159	c.159C>T	c.(157-159)ctC>ctT	p.L53L				A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	53						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGGGACCCCTCCTCCTGGAGG	0.627000													4	21					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10419894	10419894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10419894C>T	ENST00000226207.5	-	3	160	c.66G>A	c.(64-66)agG>agA	p.R22R	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	22	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CAATTCGCTCCCTTTCAGACT	0.507000													45	88					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15990197	15990197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15990197C>T	ENST00000221700.5	-	12	1451	c.1356G>A	c.(1354-1356)gaG>gaA	p.E452E	CYP4F2_ENST00000592328.1_Silent_p.E452E	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	452					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GAGGTGACCTCTCCTTGATGT	0.602000													65	186					0	0	1	0	0
KPTN	11133	broad.mit.edu	37	19	47986450	47986450	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47986450G>A	ENST00000338134.3	-	4	524	c.417C>T	c.(415-417)ctC>ctT	p.L139L	KPTN_ENST00000536339.1_5'UTR|KPTN_ENST00000595484.1_5'UTR	NM_007059.2	NP_008990.2	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	139					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			breast(1)|lung(3)|ovary(2)|pancreas(2)	8		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		GAGTGAACTGGAGCTCCAGGT	0.612000													81	177					0	0	1	0	0
FNDC3A	22862	broad.mit.edu	37	13	49742868	49742868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:49742868C>T	ENST00000492622.2	+	10	1462	c.1157C>T	c.(1156-1158)tCa>tTa	p.S386L	FNDC3A_ENST00000541916.1_Missense_Mutation_p.S386L|FNDC3A_ENST00000398316.3_Missense_Mutation_p.S330L	NM_001079673.1	NP_001073141.1	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	386	Fibronectin type-III 2.					Golgi membrane|integral to membrane				endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|prostate(5)|skin(2)|urinary_tract(1)	41		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ACCAAAAATTCACTCACTTTG	0.398000													55	156					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106704939	106704939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:106704939C>T	ENST00000546625.1	+	2	245	c.86C>T	c.(85-87)tCg>tTg	p.S29L	TCP11L2_ENST00000299045.3_Missense_Mutation_p.S29L|TCP11L2_ENST00000547153.1_Missense_Mutation_p.S29L			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	29	Ser-rich.									endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						AGCATGGCTTCGCTCAGTGAC	0.542000													7	83					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102711167	102711167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102711167G>A	ENST00000299855.5	-	5	1039	c.783C>T	c.(781-783)tcC>tcT	p.S261S		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	261					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CACCATAGAGGGACTGAATGC	0.418000													35	67					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188210	32188210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32188210G>A	ENST00000375023.3	-	6	1269	c.1131C>T	c.(1129-1131)ttC>ttT	p.F377F		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	377	EGF-like 9; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity	p.F377L(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						AGAGGCAGGAGAAAGAGCCCA	0.607000													37	136					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90024714	90024714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90024714G>A	ENST00000405460.2	+	49	10486	c.10390G>A	c.(10390-10392)Gat>Aat	p.D3464N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3464					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTCAGCCAATGATATTTACCT	0.353000													15	28					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719696	140719696	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140719696C>T	ENST00000394576.2	+	1	1158	c.1158C>T	c.(1156-1158)ctC>ctT	p.L386L	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGTTCACTCCCCGAGGATC	0.433000													40	92					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446685	10446685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:10446685G>A	ENST00000326756.3	-	3	1706	c.1268C>T	c.(1267-1269)cCt>cTt	p.P423L		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						CTGAACTGAAGGTTGAAAACT	0.343000													57	129					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109629448	109629448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109629448C>T	ENST00000338432.7	+	14	2294	c.2175C>T	c.(2173-2175)tcC>tcT	p.S725S	ACACB_ENST00000377848.3_Silent_p.S725S|ACACB_ENST00000377854.5_Silent_p.S725S			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	725	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGGAACTGTCCATCCGAGGCG	0.488000													16	82					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3784165	3784165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3784165C>T	ENST00000310132.6	-	5	717	c.319G>A	c.(319-321)Gag>Aag	p.E107K	MATK_ENST00000585778.1_Missense_Mutation_p.E107K|MATK_ENST00000395045.2_Missense_Mutation_p.E108K|MATK_ENST00000395040.2_Missense_Mutation_p.E66K	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	107	SH3.			ER -> DG (in Ref. 1; AAA16703).	cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCCCGCTCCCGCAGCGCC	0.677000													17	56					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432962	104432962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104432962C>T	ENST00000361820.3	-	3	2332	c.1732G>A	c.(1732-1734)Gga>Aga	p.G578R		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	578					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	ATGCAATATCCATAGCAGCAC	0.418000													37	51					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68115441	68115441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68115441C>T	ENST00000294304.7	+	2	324	c.218C>T	c.(217-219)tCc>tTc	p.S73F		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	73	Beta-propeller 1.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTCCAGTTTTCCAAGGGAGCC	0.657000													24	101					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136320692	136320692	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136320692C>T	ENST00000371929.3	+	25	3979	c.3535C>T	c.(3535-3537)Ctg>Ttg	p.L1179L	ADAMTS13_ENST00000356589.2_Intron|ADAMTS13_ENST00000485925.1_Intron|ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000355699.2_Intron	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	1179					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TCGGCGGCTCCTGCCCGGGCC	0.672000													23	77					0	0	1	0	0
KDM1B	221656	broad.mit.edu	37	6	18160191	18160191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:18160191C>T	ENST00000388870.2	+	3	306	c.65C>T	c.(64-66)cCt>cTt	p.P22L	KDM1B_ENST00000297792.5_Missense_Mutation_p.P22L|KDM1B_ENST00000397244.1_Missense_Mutation_p.P22L|KDM1B_ENST00000546309.2_Intron			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	22					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						GATAGCCTTCCTTTGAGGAGC	0.403000													16	32					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160853249	160853249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160853249C>T	ENST00000326245.3	-	3	241	c.126G>A	c.(124-126)aaG>aaA	p.K42K		NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	42	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTTTGATTTCCTTGCAGCTTC	0.443000													37	119					0	0	1	0	0
AMDHD1	144193	broad.mit.edu	37	12	96354255	96354255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:96354255G>A	ENST00000266736.2	+	5	773	c.667G>A	c.(667-669)Gaa>Aaa	p.E223K		NM_152435.2	NP_689648.2	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	223					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|skin(1)	22						CAGAAATGGGGAAATACACGT	0.418000													9	83					0	0	1	0	0
ATP5F1	515	broad.mit.edu	37	1	111996918	111996918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111996918C>T	ENST00000369722.3	+	3	769	c.163C>T	c.(163-165)Cgt>Tgt	p.R55C	ATP5F1_ENST00000369721.4_Intron|ATP5F1_ENST00000483994.1_Intron	NM_001688.4	NP_001679.2	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1	55					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding	p.R55C(1)		breast(1)|cervix(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGGAAAAGTTCGTTATGGACT	0.438000													50	97					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136566094	136566094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136566094C>T	ENST00000264162.2	-	8	3833	c.3823G>A	c.(3823-3825)Gga>Aga	p.G1275R		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1275	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGCCCCACTCCGTTTTCGGTG	0.502000													75	169					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160869799	160869799	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160869799G>A	ENST00000283243.7	-	10	1845	c.1639C>T	c.(1639-1641)Cct>Tct	p.P547S	PLA2R1_ENST00000392771.1_Missense_Mutation_p.P547S	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	547	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						ACAAGTGCAGGAGGACAGTAA	0.383000													19	56					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1422039	1422039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1422039G>A	ENST00000270349.9	-	5	871	c.744C>T	c.(742-744)atC>atT	p.I248I	SLC6A3_ENST00000453492.2_Silent_p.I248I	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	248					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGAGCAGCACGATGACCAGCA	0.647000													26	90					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95557267	95557267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95557267G>A	ENST00000371418.4	+	8	1641	c.1381G>A	c.(1381-1383)Gga>Aga	p.G461R	LGI1_ENST00000371413.3_Intron|LGI1_ENST00000542308.1_Missense_Mutation_p.G413R	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	461					axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				CATGAAATGGGGAGGCTCCTC	0.443000													21	72					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226549171	226549171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226549171G>A	ENST00000366794.5	-	23	3178	c.3035C>T	c.(3034-3036)tCc>tTc	p.S1012F	PARP1_ENST00000490921.1_5'UTR	NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	1012	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TTACCACAGGGAGGTCTTAAA	0.478000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					5	38					0	0	1	0	0
EDDM3B	64184	broad.mit.edu	37	14	21238679	21238679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21238679G>A	ENST00000326783.3	+	2	468	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K		NM_022360.4	NP_071755.1	P56851	EP3B_HUMAN	epididymal protein 3B	124					spermatid development	extracellular region				central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						CAACTACATTGAATTCCATTG	0.413000													12	93					0	0	1	0	0
ALPL	249	broad.mit.edu	37	1	21903920	21903920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21903920G>A	ENST00000374840.3	+	12	1604	c.1354G>A	c.(1354-1356)Gag>Aag	p.E452K	ALPL_ENST00000539907.1_Missense_Mutation_p.E375K|ALPL_ENST00000540617.1_Missense_Mutation_p.E397K|ALPL_ENST00000374829.1_Missense_Mutation_p.E98K|ALPL_ENST00000425315.2_Missense_Mutation_p.E452K|ALPL_ENST00000374830.1_Missense_Mutation_p.E98K|ALPL_ENST00000374832.1_Missense_Mutation_p.E452K	NM_000478.4	NP_000469.3	P05186	PPBT_HUMAN	alkaline phosphatase, liver/bone/kidney	452			E -> K (in HOPS).		response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	26		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	CCTGCGCCACGAGACCCACGG	0.687000													26	38					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143057231	143057231	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143057231T>A	ENST00000443739.2	-	2	188	c.40A>T	c.(40-42)Att>Ttt	p.I14F	FAM131B_ENST00000409408.1_5'UTR|FAM131B_ENST00000409578.1_Missense_Mutation_p.I14F|FAM131B_ENST00000409346.1_5'UTR|FAM131B_ENST00000409222.3_5'UTR	NM_001031690.2|NM_001278297.1	NP_001026860.2|NP_001265226.1	Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	0										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					TCCACTGCAATCACCTCATTC	0.617000													7	20					0	0	1	0	0
DDX31	64794	broad.mit.edu	37	9	135487632	135487632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135487632G>A	ENST00000372159.3	-	19	2302	c.2151C>T	c.(2149-2151)tcC>tcT	p.S717S	DDX31_ENST00000372153.1_Silent_p.S644S|DDX31_ENST00000438527.3_Silent_p.S588S	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	717						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		CTTGGATGAAGGACTGCAGAG	0.562000													9	54					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124181467	124181467	+	Missense_Mutation	SNP	G	G	A	rs139954729	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124181467G>A	ENST00000360013.3	+	25	4139	c.4012G>A	c.(4012-4014)Gat>Aat	p.D1338N	KALRN_ENST00000240874.3_Missense_Mutation_p.D1338N|KALRN_ENST00000460856.1_Missense_Mutation_p.D1329N	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1338	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGAGATCTACGATTTCCATAA	0.483000													10	40					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98288962	98288962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:98288962C>T	ENST00000322128.3	-	1	1214	c.1111G>A	c.(1111-1113)Gaa>Aaa	p.E371K		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	371					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding	p.E371Q(1)		cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CACAATTCTTCGTTGATTATC	0.468000													63	216					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109840831	109840831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109840831C>T	ENST00000357155.1	-	2	243	c.194G>A	c.(193-195)cGg>cAg	p.R65Q	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	65	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CCCAACCTTCCGGATGTAGGT	0.522000													24	125					0	0	1	0	0
NR1H4	9971	broad.mit.edu	37	12	100926317	100926317	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100926317G>A	ENST00000548884.1	+	5	1068	c.527G>A	c.(526-528)cGa>cAa	p.R176Q	NR1H4_ENST00000392986.3_Missense_Mutation_p.R176Q|NR1H4_ENST00000188403.7_Missense_Mutation_p.R186Q|NR1H4_ENST00000551379.1_Missense_Mutation_p.R186Q|NR1H4_ENST00000549996.1_Intron	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	186					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						ATGTACATGCGAAGAAAGTGT	0.408000													28	75					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848369	123848369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123848369C>T	ENST00000531945.1	-	1	119	c.30G>A	c.(28-30)atG>atA	p.M10I		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TTGTCATGGTCATCTTCTCAC	0.468000													44	81					0	0	1	0	0
SPN	6693	broad.mit.edu	37	16	29675707	29675707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29675707G>A	ENST00000360121.3	+	2	750	c.658G>A	c.(658-660)Gga>Aga	p.G220R	SPN_ENST00000395389.2_Missense_Mutation_p.G220R|AC009133.19_ENST00000449759.1_Intron	NM_001030288.2|NM_003123.4	NP_001025459.1|NP_003114.1	P16150	LEUK_HUMAN	sialophorin	220					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|stomach(1)	15						CGGGGCCAGTGGACCCCAGGT	0.567000													14	125					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201778347	201778347	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201778347C>T	ENST00000367296.4	+	21	4683	c.4263C>T	c.(4261-4263)ctC>ctT	p.L1421L	IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367295.1_Silent_p.L1027L|NAV1_ENST00000367302.1_Silent_p.L1374L|NAV1_ENST00000295624.6_Silent_p.L1418L|NAV1_ENST00000367300.3_Silent_p.L1361L|NAV1_ENST00000367297.4_Silent_p.L1413L	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1421					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						AAGTGACCCTCCGGGTGGTGG	0.512000													49	158					0	0	1	0	0
OR4F17	81099	broad.mit.edu	37	19	110706	110706	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:110706C>T	ENST00000585993.1	+	2	167	c.28C>T	c.(28-30)Ctc>Ttc	p.L10F	OR4F17_ENST00000318050.3_Missense_Mutation_p.L10F			Q8NGA8	O4F17_HUMAN	olfactory receptor, family 4, subfamily F, member 17	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(2)	2		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTTCTGGGTCTCTCTGATTC	0.393000													69	507					0	0	1	0	0
AKR1C3	8644	broad.mit.edu	37	10	5147850	5147850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5147850C>T	ENST00000380554.3	+	8	1562	c.910C>T	c.(910-912)Cac>Tac	p.H304Y	AKR1C3_ENST00000605149.1_Missense_Mutation_p.H281Y|AKR1C3_ENST00000439082.2_Missense_Mutation_p.H185Y	NM_001253908.1|NM_003739.5	NP_001240837.1|NP_003730.4	P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3	304					prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	CAGAAATCTCCACTATTTTAA	0.358000													13	35					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97920070	97920070	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97920070C>T	ENST00000534948.1	+	0	4848							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		GCGGCTTTTCCCTTTTAGTTC	0.393000													27	54					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117171115	117171115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117171115C>T	ENST00000003084.6	+	4	568	c.436C>T	c.(436-438)Cat>Tat	p.H146Y	CFTR_ENST00000454343.1_Missense_Mutation_p.H146Y	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	146	ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTTTGGCCTTCATCACATTGG	0.418000									Cystic Fibrosis				8	56					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103717	52103717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52103717G>A	ENST00000361781.2	-	7	1117	c.158C>T	c.(157-159)tCc>tTc	p.S53F	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Missense_Mutation_p.S53F	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	59	SAM.				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						ATTGTCAGAGGAGACTCGGCA	0.517000													36	61					0	0	1	0	0
TRIM61	391712	broad.mit.edu	37	4	165891019	165891019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:165891019C>T	ENST00000329314.5	-	3	748	c.136G>A	c.(136-138)Gat>Aat	p.D46N		NM_001012414.2	NP_001012414.1	Q5EBN2	TRI61_HUMAN	tripartite motif containing 61	46						intracellular	zinc ion binding			NS(1)|kidney(1)|liver(1)|skin(1)|upper_aerodigestive_tract(1)	5	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.155)		TCATGTAGATCCTTCCAGGAC	0.463000													27	116					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6692287	6692287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6692287G>A	ENST00000309577.6	-	26	4300	c.4137C>T	c.(4135-4137)ctC>ctT	p.L1379L	RP5-940J5.6_ENST00000501075.2_RNA|CHD4_ENST00000357008.2_Intron|CHD4_ENST00000544484.1_Silent_p.L1376L|CHD4_ENST00000540960.1_Intron|CHD4_ENST00000544040.1_Intron			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1353					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						AATCTGGAGGGAGAGAGGGCA	0.607000													13	123					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18892399	18892399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18892399C>T	ENST00000380548.4	+	26	4995	c.4656C>T	c.(4654-4656)acC>acT	p.T1552T	ADAMTSL1_ENST00000380545.5_Silent_p.T253T	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1552	TSP type-1 8.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GGATGGTGACCTCCTGGTCTG	0.612000													6	10					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33234287	33234287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33234287C>T	ENST00000401073.2	+	4	567	c.497C>T	c.(496-498)tCc>tTc	p.S166F	KIAA1522_ENST00000373481.3_Missense_Mutation_p.S118F|KIAA1522_ENST00000373480.1_Missense_Mutation_p.S107F|KIAA1522_ENST00000294521.3_Missense_Mutation_p.S107F	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	107										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GACAACATCTCCTTCTGCAGT	0.562000													13	55					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71742858	71742858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71742858G>A	ENST00000258104.3	+	7	1046	c.769G>A	c.(769-771)Gga>Aga	p.G257R	DYSF_ENST00000394120.2_Missense_Mutation_p.G258R|DYSF_ENST00000409744.1_Missense_Mutation_p.G258R|DYSF_ENST00000410020.3_Missense_Mutation_p.G289R|DYSF_ENST00000413539.2_Missense_Mutation_p.G288R|DYSF_ENST00000429174.2_Missense_Mutation_p.G257R|DYSF_ENST00000409366.1_Missense_Mutation_p.G258R|DYSF_ENST00000409582.3_Missense_Mutation_p.G288R|DYSF_ENST00000409762.1_Missense_Mutation_p.G288R|DYSF_ENST00000409651.1_Missense_Mutation_p.G289R|DYSF_ENST00000410041.1_Missense_Mutation_p.G289R	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	257	C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GATCCACAAGGGAAACAGCCC	0.612000													17	54					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62286063	62286063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62286063G>A	ENST00000378024.4	-	5	16100	c.15826C>T	c.(15826-15828)Ccc>Tcc	p.P5276S	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5276					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GAAACATCGGGCCCTTCGAGC	0.537000													20	71					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84473122	84473122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84473122C>T	ENST00000416219.2	+	13	1290	c.1201C>T	c.(1201-1203)Cgt>Tgt	p.R401C	ATP2C2_ENST00000420010.2_3'UTR|ATP2C2_ENST00000262429.4_Missense_Mutation_p.R401C			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	401					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						AGATGGGCTTCGTGCCGAGGT	0.493000													49	108					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7581370	7581370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7581370G>A	ENST00000379802.3	+	23	5288	c.4947G>A	c.(4945-4947)agG>agA	p.R1649R	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1649	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAAAGCAGAGGACCCAGGAAG	0.572000													35	73					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4153693	4153693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4153693G>A	ENST00000404826.2	+	25	3749	c.3610G>A	c.(3610-3612)Ggg>Agg	p.G1204R	SDK1_ENST00000389531.3_Missense_Mutation_p.G1204R	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1204	Fibronectin type-III 6.				cell adhesion	integral to membrane		p.G1204R(1)		NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCAGTACAACGGGAACCCCGA	0.587000													17	38					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049251	42049251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42049251G>A	ENST00000372584.1	-	3	2232	c.1218C>T	c.(1216-1218)ccC>ccT	p.P406P	HIVEP3_ENST00000247584.5_Silent_p.P406P|HIVEP3_ENST00000372583.1_Silent_p.P406P|HIVEP3_ENST00000429157.2_Silent_p.P406P	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	406	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Ser-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGTGTTTGGGGGGCTGACCT	0.592000													17	99					0	0	1	0	0
ZNF813	126017	broad.mit.edu	37	19	53994932	53994932	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53994932C>T	ENST00000396403.4	+	4	1574	c.1446C>T	c.(1444-1446)ctC>ctT	p.L482L	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	482					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TTTCAGCCCTCGTAATTCATA	0.403000													18	68					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20466293	20466293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:20466293C>T	ENST00000377252.3	+	9	1857	c.1016C>T	c.(1015-1017)tCt>tTt	p.S339F	PLXDC2_ENST00000377238.2_3'UTR|PLXDC2_ENST00000377242.3_Missense_Mutation_p.S290F	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	339	PSI.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						CCCTGTGTATCTTCTCAGATT	0.348000													47	133					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142569571	142569571	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142569571G>A	ENST00000359396.3	-	15	2312	c.2067C>T	c.(2065-2067)tcC>tcT	p.S689S		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	689					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					CACTGCTGCGGGAGGTACTTC	0.572000													12	54					0	0	1	0	0
CTD-2090I13.1	0	broad.mit.edu	37	1	227618340	227618340	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:227618340G>A	ENST00000445817.1	+	0	1575																											GCTGTGGGTCGAAGATATGCT	0.502000													15	51					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168845770	168845770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168845770G>A	ENST00000464456.1	-	4	1328	c.128C>T	c.(127-129)cCa>cTa	p.P43L	MECOM_ENST00000433243.2_Missense_Mutation_p.P43L|MECOM_ENST00000460814.1_Missense_Mutation_p.P43L|MECOM_ENST00000392736.3_Missense_Mutation_p.P43L|MECOM_ENST00000472280.1_Missense_Mutation_p.P43L|MECOM_ENST00000264674.3_Missense_Mutation_p.P107L|MECOM_ENST00000468789.1_Missense_Mutation_p.P43L|MECOM_ENST00000494292.1_Missense_Mutation_p.P231L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						AGTACTGCATGGAAACTTTTG	0.438000													59	147					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	782337	782337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:782337G>A	ENST00000540986.1	-	7	1989	c.554C>T	c.(553-555)tCc>tTc	p.S185F	NARFL_ENST00000301694.5_3'UTR|NARFL_ENST00000568545.1_Missense_Mutation_p.S185F|NARFL_ENST00000562862.1_5'UTR|NARFL_ENST00000251588.2_Missense_Mutation_p.S287F			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	287					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				GTCGGGGAGGGAGACGCCCTC	0.527000													65	156					0	0	1	0	0
RNF169	254225	broad.mit.edu	37	11	74500681	74500681	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74500681C>T	ENST00000299563.4	+	2	526	c.513C>T	c.(511-513)ttC>ttT	p.F171F		NM_001098638.1	NP_001092108.1	Q8NCN4	RN169_HUMAN	ring finger protein 169	171							zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	15						ACTTTATATTCAGAGCACCAA	0.343000													11	137					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37936686	37936686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37936686G>A	ENST00000199447.4	+	17	2131	c.1759G>A	c.(1759-1761)Gaa>Aaa	p.E587K	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.E587K	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	587	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										GGATCCTGAGGAAAACTAAAG	0.353000													14	41					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180566	124180566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124180566C>T	ENST00000357821.2	-	1	167	c.97G>A	c.(97-99)Gga>Aga	p.G33R		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ACATAGATTCCCAGGAACAGG	0.483000													45	106					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3779070	3779070	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3779070G>A	ENST00000310132.6	-	12	1515	c.1117C>T	c.(1117-1119)Ctg>Ttg	p.L373L	MATK_ENST00000585778.1_Silent_p.L373L|MATK_ENST00000395045.2_Silent_p.L374L|MATK_ENST00000395040.2_Silent_p.L332L	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	373	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTTGGCCAGGCCAAAGTCG	0.637000													10	30					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183777966	183777966	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183777966G>A	ENST00000318351.1	+	9	1204	c.1170G>A	c.(1168-1170)ggG>ggA	p.G390G		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	390						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGTTAGCAGGGAAGAAGCTGG	0.607000													13	36					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20490544	20490544	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20490544G>A	ENST00000555186.1	+	0	524					NR_038836.1																						TGGATCCAAAGGCATGTTTTA	0.438000													14	305					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503381	140503381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140503381C>T	ENST00000194152.1	+	1	1801	c.1801C>T	c.(1801-1803)Ctg>Ttg	p.L601L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		601	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAACGCCTGGCTGTCGTACCA	0.731000													39	89					0	0	1	0	0
SLC17A4	10050	broad.mit.edu	37	6	25769328	25769328	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25769328C>T	ENST00000377905.4	+	3	326	c.207C>T	c.(205-207)gcC>gcT	p.A69A	SLC17A4_ENST00000397076.2_Silent_p.A15A|SLC17A4_ENST00000439485.2_Silent_p.A69A	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	69					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ACAACACAGCCCCACCTAGCC	0.468000													27	80					0	0	1	0	0
YBX3	8531	broad.mit.edu	37	12	10856655	10856655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10856655G>A	ENST00000228251.4	-	7	1073	c.873C>T	c.(871-873)taC>taT	p.Y291Y	YBX3_ENST00000279550.7_Silent_p.Y222Y|YBX3_ENST00000546164.1_Intron	NM_003651.4	NP_003642.3			Y box binding protein 3																		CATACCTACGGTACCTTGGGC	0.478000													11	73					0	0	1	0	0
TRAV38-2DV8	28643	broad.mit.edu	37	14	22749540	22749540	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22749540G>A	ENST00000390465.2	+	0	304																											GTTTCTCTGTGAACTTCCAGA	0.468000													22	38					0	0	1	0	0
TRIM6	117854	broad.mit.edu	37	11	5625954	5625954	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5625954G>A	ENST00000507320.1	+	0	388				TRIM6_ENST00000506134.1_Intron|TRIM6-TRIM34_ENST00000354852.5_Intron|TRIM6_ENST00000445329.1_Intron|TRIM6_ENST00000380107.1_Intron|TRIM6_ENST00000278302.5_Intron|TRIM6_ENST00000380097.3_Intron|TRIM6_ENST00000515022.1_Intron|HBG2_ENST00000380259.2_Intron|AC015691.13_ENST00000394793.2_RNA					tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		TCTGTCCTCTGATGCCATGAC	0.488000													3	9					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502502	91502502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91502502G>A	ENST00000266718.4	-	2	709	c.255C>T	c.(253-255)gcC>gcT	p.A85A	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	85					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						CATTCTCAAAGGCCTTTTCAT	0.378000													21	45					0	0	1	0	0
HEXIM2	124790	broad.mit.edu	37	17	43246863	43246863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43246863G>A	ENST00000307275.3	+	4	984	c.548G>A	c.(547-549)cGa>cAa	p.R183Q	HEXIM2_ENST00000592695.1_Missense_Mutation_p.R183Q|HEXIM2_ENST00000591576.1_Missense_Mutation_p.R183Q|RP13-890H12.2_ENST00000589796.1_RNA	NM_144608.1	NP_653209.1	Q96MH2	HEXI2_HUMAN	hexamethylene bis-acetamide inducible 2	183					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			endometrium(1)|large_intestine(3)|lung(1)	5						GGGCGGGGCCGAGCGCACGGT	0.652000													9	9					0	0	1	0	0
NPIPB15	440348	broad.mit.edu	37	16	74425514	74425514	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:74425514C>A	ENST00000429990.1	+	7	964	c.868C>A	c.(868-870)Ctt>Att	p.L290I						nuclear pore complex interacting protein family, member B15																		TCTTGCTCCTCTTCCACCCTC	0.502000													21	311					2.65835e-16	2.67292e-16	1	1	0
UNC13A	23025	broad.mit.edu	37	19	17768936	17768936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17768936G>A	ENST00000428389.2	-	10	965	c.966C>T	c.(964-966)ggC>ggT	p.G322G	UNC13A_ENST00000552293.1_Silent_p.G234G|UNC13A_ENST00000519716.2_Silent_p.G234G|UNC13A_ENST00000551649.1_Silent_p.G234G|UNC13A_ENST00000550896.1_Silent_p.G234G|UNC13A_ENST00000252773.7_Silent_p.G234G			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	234	Glu-rich.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						ACTCCCGGGAGCCCAGGGGTG	0.582000													10	28					0	0	1	0	0
LIM2	3982	broad.mit.edu	37	19	51890686	51890686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51890686G>A	ENST00000221973.3	-	2	54	c.12C>T	c.(10-12)ttC>ttT	p.F4F	LIM2_ENST00000596399.1_Silent_p.F4F	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	4					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		CACCACCCATGAAGCTGTACA	0.607000													20	45					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35453185	35453185	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35453185G>A	ENST00000357182.4	-	16	3725	c.3498C>T	c.(3496-3498)ttC>ttT	p.F1166F	ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000487874.1_Intron|ZMYM6_ENST00000373340.2_Intron	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	1166					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AAAATGAAGggaacatgtcat	0.333000													17	38					0	0	1	0	0
LRP10	26020	broad.mit.edu	37	14	23344336	23344336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23344336C>T	ENST00000359591.4	+	4	979	c.288C>T	c.(286-288)tcC>tcT	p.S96S	LRP10_ENST00000546834.1_Silent_p.S96S	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	96	CUB 1.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		CACTGATCTCCCTGTGTGAGG	0.622000													13	49					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135975712	135975712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135975712G>A	ENST00000393160.3	-	17	2700	c.2347C>T	c.(2347-2349)Ctg>Ttg	p.L783L	RALGDS_ENST00000372047.3_Silent_p.L826L|RALGDS_ENST00000372062.3_Silent_p.L809L|RALGDS_ENST00000542690.1_Silent_p.L909L|RALGDS_ENST00000372050.3_Silent_p.L838L|RALGDS_ENST00000393157.3_Silent_p.L837L|RALGDS_ENST00000469972.1_5'UTR	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	838					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		TCCTCCTCCAGGTTGTGTTTG	0.597000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								122	200					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240637445	240637445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240637445G>A	ENST00000319653.9	+	18	5390	c.5160G>A	c.(5158-5160)atG>atA	p.M1720I	AL646016.1_ENST00000596886.1_Intron|FMN2_ENST00000545751.1_Missense_Mutation_p.M316I|FMN2_ENST00000543681.1_Missense_Mutation_p.M40I|FMN2_ENST00000496950.1_3'UTR	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1720					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AGATAAGCATGAAAACTTGAA	0.338000													7	32					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116605816	116605816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116605816C>T	ENST00000369248.4	+	9	1508	c.1173C>T	c.(1171-1173)ttC>ttT	p.F391F	FAM160B1_ENST00000369250.3_Silent_p.F391F	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	391										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						AAAGATTTTTCATTGGTGTTA	0.338000													51	213					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82836319	82836319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82836319C>T	ENST00000265077.3	+	8	8062	c.7497C>T	c.(7495-7497)tcC>tcT	p.S2499S	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.S1512S|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2499	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACAAAAGCTCCCCTGATCCAA	0.463000													12	76					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42113243	42113243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42113243C>T	ENST00000457542.2	+	23	2981	c.2695C>T	c.(2695-2697)Ctt>Ttt	p.L899F	MAPKBP1_ENST00000221214.6_Missense_Mutation_p.L782F|MAPKBP1_ENST00000260357.7_Missense_Mutation_p.L738F|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.L905F|MAPKBP1_ENST00000514566.1_Missense_Mutation_p.L899F	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	905										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		GCAGGAGGCCCTTGAGACTTC	0.612000													15	72					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71423699	71423699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71423699C>T	ENST00000302628.4	+	11	824	c.747C>T	c.(745-747)tcC>tcT	p.S249S	CALB2_ENST00000349553.5_3'UTR	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	249	EF-hand 6.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				GCGTCATGTCCTTGGCAGAGG	0.562000													39	201					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424692	125424692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125424692G>A	ENST00000373686.1	+	1	848	c.848G>A	c.(847-849)gGa>gAa	p.G283E				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G283A(1)		breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TCAGCTGCTGGAAAGCGTAAA	0.428000													77	160					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22624383	22624383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:22624383G>A	ENST00000333957.4	-	20	2563	c.2308C>T	c.(2308-2310)Ctt>Ttt	p.L770F	C2CD5_ENST00000396028.2_Missense_Mutation_p.L761F|C2CD5_ENST00000536386.1_Missense_Mutation_p.L772F|C2CD5_ENST00000545552.1_Missense_Mutation_p.L783F|C2CD5_ENST00000446597.1_Missense_Mutation_p.L770F|C2CD5_ENST00000542676.1_Missense_Mutation_p.L770F|C2CD5_ENST00000544930.1_Missense_Mutation_p.L585F	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		ACATGGCAAAGGCAGCAGGGG	0.284000													38	69					0	0	1	0	0
ATG4A	115201	broad.mit.edu	37	X	107393513	107393513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107393513C>T	ENST00000372232.3	+	10	1105	c.946C>T	c.(946-948)Cct>Tct	p.P316S	ATG4A_ENST00000345734.3_Missense_Mutation_p.P254S|ATG4A_ENST00000372254.3_Missense_Mutation_p.P292S|ATG4A_ENST00000545696.1_Missense_Mutation_p.P177S|COL4A6_ENST00000418180.1_Intron|ATG4A_ENST00000489247.1_3'UTR	NM_052936.3	NP_443168.2	Q8WYN0	ATG4A_HUMAN	autophagy related 4A, cysteine peptidase	316					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						AAACCTGGATCCTTCAGTTGC	0.488000													22	104					0	0	1	0	0
CARF	79800	broad.mit.edu	37	2	203834641	203834641	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:203834641G>A	ENST00000320443.8	+	10	1996		c.e10-1		CARF_ENST00000402905.2_Splice_Site|CARF_ENST00000438828.2_Splice_Site|CARF_ENST00000456821.2_Splice_Site|CARF_ENST00000414439.1_Splice_Site|CARF_ENST00000545262.1_Splice_Site|CARF_ENST00000428585.1_Splice_Site|WDR12_ENST00000477723.1_Intron|CARF_ENST00000545253.1_Splice_Site					calcium responsive transcription factor																		CTTGTATAAAGGATTTACATT	0.294000													13	40					0	0	1	0	0
KDM5D	8284	broad.mit.edu	37	Y	21878326	21878326	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:21878326G>C	ENST00000541639.1	-	16	2250	c.1963C>G	c.(1963-1965)Cgc>Ggc	p.R655G	KDM5D_ENST00000317961.4_Missense_Mutation_p.R624G|KDM5D_ENST00000382806.2_Missense_Mutation_p.R567G	NM_001146705.1	NP_001140177.1	Q9BY66	KDM5D_HUMAN	lysine (K)-specific demethylase 5D	624					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(1)|large_intestine(9)|lung(6)|skin(1)	17					Vitamin C(DB00126)	CGGAGCCGGCGGTAGTGTTCA	0.527000													25	14					0	0	1	0	0
MPP4	58538	broad.mit.edu	37	2	202549867	202549867	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202549867C>T	ENST00000409474.3	-	7	701	c.492_splice	c.e7-1	p.G165_splice	MPP4_ENST00000447335.2_Splice_Site_p.G165_splice|MPP4_ENST00000409143.1_Splice_Site_p.G138_splice|MPP4_ENST00000396886.3_Splice_Site_p.G121_splice|MPP4_ENST00000359962.5_Splice_Site_p.G165_splice|MPP4_ENST00000315506.7_Splice_Site_p.G165_splice|MPP4_ENST00000428900.2_Splice_Site_p.G165_splice	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	165	PDZ.					cytoplasm	protein binding			kidney(1)|lung(11)	12						GATGGTGGCTCCCTGAAGAGA	0.542000													3	16					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051521	17051521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:17051521C>T	ENST00000418129.2	+	2	770	c.305C>T	c.(304-306)tCa>tTa	p.S102L	PLCL2_ENST00000396755.2_Missense_Mutation_p.S102L|PLCL2_ENST00000460467.1_3'UTR|PLCL2_ENST00000432376.1_Missense_Mutation_p.S102L	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	228					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						AATTATGAGTCACTGGATTTG	0.403000													58	147					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4879714	4879714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:4879714G>A	ENST00000298375.7	+	5	594	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K	AKR1E2_ENST00000532248.1_Missense_Mutation_p.E175K|AKR1E2_ENST00000334019.4_Missense_Mutation_p.E175K|AKR1E2_ENST00000525281.1_3'UTR|AKR1E2_ENST00000345253.5_Intron	NM_001040177.1	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	175						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						CTTCAACCATGAACAGCTTGA	0.507000													19	46					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94586593	94586593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94586593G>A	ENST00000370225.3	-	1	95	c.9C>T	c.(7-9)ttC>ttT	p.F3F	ABCA4_ENST00000535735.1_Silent_p.F3F	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	3					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTGTCTCACGAAGCCCATGC	0.507000													37	71					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56031306	56031306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56031306C>T	ENST00000309675.2	+	1	663	c.631C>T	c.(631-633)Ccc>Tcc	p.P211S		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						CATTATGATCCCCTTCTCTCT	0.557000													38	106					0	0	1	0	0
CREB3L2	64764	broad.mit.edu	37	7	137570244	137570244	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:137570244G>A	ENST00000330387.6	-	9	1399	c.1048C>T	c.(1048-1050)Ctc>Ttc	p.L350F	CREB3L2_ENST00000456390.1_Missense_Mutation_p.L350F	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	350	Leucine-zipper.				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						TGCTGAAGGAGAGTCCTGCCA	0.532000			T	FUS	fibromyxoid sarcoma								25	63					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124252337	124252337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124252337C>T	ENST00000375013.2	-	1	921	c.903G>A	c.(901-903)agG>agA	p.R301R		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TCAGAGCTTTCCTCAGTGCAA	0.348000													32	85					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238436	104238436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104238436G>A	ENST00000374851.1	-	4	2086	c.939C>T	c.(937-939)ttC>ttT	p.F313F	TMEM246_ENST00000374848.3_Silent_p.F313F|RP11-490D19.6_ENST00000424154.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000450109.1_RNA|TMEM246_ENST00000374847.1_Silent_p.F313F			Q9BRR3	CI125_HUMAN	transmembrane protein 246	313						integral to membrane											GCAGTTCCAGGAAATAGTGCC	0.607000													48	78					0	0	1	0	0
TELO2	9894	broad.mit.edu	37	16	1556972	1556972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1556972C>T	ENST00000262319.6	+	18	2425	c.2146C>T	c.(2146-2148)Ctc>Ttc	p.L716F		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	716						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				GACCTTCGACCTCTTGGGAGA	0.657000													4	26					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740201	37740201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37740201C>T	ENST00000539465.1	+	15	2269	c.1676C>T	c.(1675-1677)cCt>cTt	p.P559L	FRMPD1_ENST00000541302.1_Missense_Mutation_p.P428L|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000536622.1_Missense_Mutation_p.P381L|FRMPD1_ENST00000377765.3_Missense_Mutation_p.P559L			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	559						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GAGGAGCAGCCTCCTGGGAAC	0.632000													13	61					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44432665	44432665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44432665C>T	ENST00000372343.3	+	18	3249	c.2587C>T	c.(2587-2589)Cgt>Tgt	p.R863C	IPO13_ENST00000372339.3_Missense_Mutation_p.R81C	NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	863					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GGAAGACGGTCGTATGCTGCT	0.612000													24	59					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24242028	24242028	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24242028G>A	ENST00000256412.4	+	1	231	c.11G>A	c.(10-12)gGg>gAg	p.G4E	ADAMDEC1_ENST00000522298.1_5'UTR|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000538205.1_5'UTR|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA	NM_014479.3	NP_055294.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	4					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		ATGCTGCGTGGGATCTCCCAG	0.468000													12	18					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542276	55542276	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55542276A>G	ENST00000220676.1	+	4	5982	c.5834A>G	c.(5833-5835)aAt>aGt	p.N1945S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1945					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GATATTGAAAATTTCTTGGGT	0.353000													23	93					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57335973	57335973	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57335973G>A	ENST00000326441.9	-	4	414	c.51C>T	c.(49-51)gcC>gcT	p.A17A	PEG3_ENST00000594706.1_Intron|PEG3_ENST00000423103.2_Silent_p.A17A|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Intron|PEG3_ENST00000598410.1_Intron|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	17					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACAGATTTGGGGCCCAGGACT	0.453000													32	73					0	0	1	0	0
PPA2	27068	broad.mit.edu	37	4	106317465	106317465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:106317465G>A	ENST00000341695.5	-	9	840	c.810C>T	c.(808-810)tcC>tcT	p.S270S	PPA2_ENST00000432483.2_Silent_p.S168S|PPA2_ENST00000348706.5_Silent_p.S241S|PPA2_ENST00000354147.3_Silent_p.S104S|PPA2_ENST00000380004.2_Silent_p.S252S|PPA2_ENST00000357415.4_Silent_p.S285S	NM_176869.2	NP_789845.1	Q9H2U2	IPYR2_HUMAN	pyrophosphatase (inorganic) 2	270					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	11		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)		ATTGATGAGTGGATTTAATAA	0.294000													41	112					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108010940	108010940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108010940C>T	ENST00000280758.5	+	8	2604	c.2076C>T	c.(2074-2076)ctC>ctT	p.L692L	BTBD11_ENST00000357167.4_Silent_p.L229L|RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000420571.2_Silent_p.L692L|BTBD11_ENST00000490090.2_Silent_p.L692L	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	692						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AAACACCCCTCCAGCTGGCAG	0.587000													17	106					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921487	24921487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24921487G>A	ENST00000329468.2	+	1	947	c.473G>A	c.(472-474)aGa>aAa	p.R158K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GAAGGGCCCAGAAGAGTGAAG	0.617000													12	37					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	71535177	71535177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71535177C>T	ENST00000355327.3	+	5	788	c.654C>T	c.(652-654)gtC>gtT	p.V218V	THSD4_ENST00000261862.6_Silent_p.V218V			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	218	TSP type-1 1.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CCCACCAGGTCCCCCAACATG	0.602000													34	85					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228155603	228155603	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228155603G>A	ENST00000396578.3	+	37	3372		c.e37+1		AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)						activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGGACCAACGGTATATAGGCC	0.478000													5	21					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41008721	41008721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41008721G>A	ENST00000399564.4	-	33	4045	c.3595C>T	c.(3595-3597)Cca>Tca	p.P1199S	MROH2B_ENST00000506092.2_Missense_Mutation_p.P754S	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B									p.P1199S(1)									CAGGGGTCTGGGATCTGCTGC	0.567000													26	47					0	0	1	0	0
SLC25A32	81034	broad.mit.edu	37	8	104412716	104412716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:104412716G>A	ENST00000297578.4	-	7	1037	c.871C>T	c.(871-873)Cca>Tca	p.P291S	SLC25A32_ENST00000543107.1_Missense_Mutation_p.P159S	NM_030780.3	NP_110407.2	Q9H2D1	MFTC_HUMAN	solute carrier family 25 (mitochondrial folate carrier), member 32	291					folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	9			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	CAGCAGGCTGGAGTCACTCTA	0.368000													13	140					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	169985283	169985283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169985283G>A	ENST00000263816.3	-	79	14143	c.13858C>T	c.(13858-13860)Cct>Tct	p.P4620S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4620					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGCTTAGCAGGGAGCGAAGGT	0.453000													46	129					0	0	1	0	0
GPM6A	2823	broad.mit.edu	37	4	176556167	176556167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:176556167C>T	ENST00000280187.7	-	8	771	c.726G>A	c.(724-726)gtG>gtA	p.V242V	GPM6A_ENST00000393658.2_Silent_p.V242V|GPM6A_ENST00000515090.1_Silent_p.V235V|GPM6A_ENST00000506219.1_5'UTR|GPM6A_ENST00000506894.1_Silent_p.V231V	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	242			V -> L (in dbSNP:rs1049820).			cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		AGGCGTCTTTCACATAGGCCC	0.433000													16	43					0	0	1	0	0
MYBL2	4605	broad.mit.edu	37	20	42344708	42344708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42344708G>A	ENST00000217026.4	+	14	2211	c.2084G>A	c.(2083-2085)cGg>cAg	p.R695Q	MYBL2_ENST00000396863.4_Missense_Mutation_p.R671Q	NM_002466.2	NP_002457.1	P10244	MYBB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog-like 2	695						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	46		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CACACATCTCGGACCCTCATC	0.607000													54	210					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12225853	12225853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12225853C>T	ENST00000256194.4	+	4	609	c.321C>T	c.(319-321)taC>taT	p.Y107Y	MICAL2_ENST00000527546.1_Silent_p.Y107Y|MICAL2_ENST00000342902.5_Silent_p.Y107Y|MICAL2_ENST00000537344.1_Silent_p.Y107Y|MICAL2_ENST00000527195.1_3'UTR|MICAL2_ENST00000379612.3_Silent_p.Y107Y	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	107						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		AACTTGCCTACCTGGGAGCCA	0.567000													10	56					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624347	123624347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123624347C>T	ENST00000327930.2	-	1	906	c.880G>A	c.(880-882)Gag>Aag	p.E294K		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CCCTTCACCTCCTTGTTTCTA	0.403000													57	142					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74013916	74013916	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74013916C>T	ENST00000301607.3	-	14	1867	c.1614G>A	c.(1612-1614)ctG>ctA	p.L538L	EVPL_ENST00000586740.1_Silent_p.L560L	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	538	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CTATCTGTCCCAGGTCTCCAT	0.672000													21	53					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111866190	111866190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111866190G>A	ENST00000440460.2	+	17	1885	c.1588G>A	c.(1588-1590)Gat>Aat	p.D530N	DIXDC1_ENST00000315253.5_Missense_Mutation_p.D319N|DIXDC1_ENST00000389821.4_3'UTR	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	531					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		CAGTGGCCACGATCCTCAGCA	0.542000													28	66					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89068470	89068470	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:89068470T>G	ENST00000286614.6	-	8	1540	c.1259A>C	c.(1258-1260)cAa>cCa	p.Q420P		NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	420	Hemopexin-like 2.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GTAACCAGGTTGAAGAGTTGT	0.363000													33	67					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169127034	169127034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169127034G>A	ENST00000256935.8	+	13	1229	c.1149G>A	c.(1147-1149)atG>atA	p.M383I		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	383					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGTGACCATGAAGATGCTGG	0.582000													46	177					0	0	1	0	0
TMPRSS12	283471	broad.mit.edu	37	12	51237684	51237684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51237684G>A	ENST00000551456.1	+	2	292	c.247G>A	c.(247-249)Gaa>Aaa	p.E83K	TMPRSS12_ENST00000398458.3_Missense_Mutation_p.E83K			Q86WS5	TMPSC_HUMAN	transmembrane (C-terminal) protease, serine 12	83	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	18						AGGGGGCACCGAAGCACAAGC	0.473000													6	6					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6243300	6243300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6243300G>A	ENST00000400104.3	-	7	653	c.453C>T	c.(451-453)atC>atT	p.I151I	L3MBTL4_ENST00000400105.2_Silent_p.I151I|L3MBTL4_ENST00000317931.7_Silent_p.I151I|L3MBTL4_ENST00000284898.6_Silent_p.I151I			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	151					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TACCCTTAGGGATGTGCAGTT	0.368000													26	88					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18896805	18896805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18896805C>T	ENST00000542601.2	-	12	1749	c.1360G>A	c.(1360-1362)Gtg>Atg	p.V454M	COMP_ENST00000222271.2_Missense_Mutation_p.V487M|COMP_ENST00000425807.1_Missense_Mutation_p.V434M			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	487					anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						GGGTTAGGCACCAGGCGGCAG	0.716000													6	27					0	0	1	0	0
IGHV4-59	28392	broad.mit.edu	37	14	107083658	107083658	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107083658G>A	ENST00000455737.1	-	0	67																											GCTGCCACCAGGAGAAGGAAG	0.507000													18	71					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52902752	52902752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52902752G>A	ENST00000356971.3	-	4	630	c.141C>T	c.(139-141)aaC>aaT	p.N47N	ICK_ENST00000350082.5_Silent_p.N47N	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	47	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					CCTCCCGAAGGTTCATGCATT	0.299000													22	47					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102494353	102494353	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102494353C>T	ENST00000360184.4	+	48	9507	c.9343C>T	c.(9343-9345)Ctg>Ttg	p.L3115L		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3115	AAA 4 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TAAGATGGATCTGGAGAAGCC	0.478000													15	234					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833794	61833794	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61833794G>A	ENST00000280772.1	-	37	7036	c.6845C>T	c.(6844-6846)tCc>tTc	p.S2282F	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2282					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATCCCGCCCGGACTGAAAGGC	0.493000													14	188					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23762076	23762076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:23762076C>T	ENST00000397312.2	-	2	431	c.157G>A	c.(157-159)Gag>Aag	p.E53K	ELAVL2_ENST00000223951.6_Missense_Mutation_p.E53K|ELAVL2_ENST00000544538.1_Missense_Mutation_p.E53K|ELAVL2_ENST00000380110.4_Missense_Mutation_p.E82K|ELAVL2_ENST00000380117.1_Missense_Mutation_p.E53K	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	53	RRM 1.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TTTAGTTCCTCCTGTGTCATG	0.398000													19	112					0	0	1	0	0
LGALS3BP	3959	broad.mit.edu	37	17	76967691	76967691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76967691G>A	ENST00000262776.3	-	6	2033	c.1725C>T	c.(1723-1725)ccC>ccT	p.P575P	LGALS3BP_ENST00000591778.1_3'UTR	NM_005567.3	NP_005558.1	Q08380	LG3BP_HUMAN	lectin, galactoside-binding, soluble, 3 binding protein	575					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(5)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			TCAGGTAGAAGGGGCGGATGA	0.647000											OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	34					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2025692	2025692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2025692C>T	ENST00000568546.1	+	10	1096	c.968C>T	c.(967-969)tCc>tTc	p.S323F		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	323					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						GAGGCTCGCTCCCTGCGGCTG	0.667000													11	44					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76912528	76912528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76912528G>A	ENST00000409709.3	+	36	5160	c.4888G>A	c.(4888-4890)Gga>Aga	p.G1630R	MYO7A_ENST00000409619.2_Missense_Mutation_p.G1581R|MYO7A_ENST00000458637.2_Missense_Mutation_p.G1592R	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1630	SH3.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CTTTGCCAAGGGAGACCTCAT	0.597000													15	29					0	0	1	0	0
ERP27	121506	broad.mit.edu	37	12	15090925	15090925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15090925G>A	ENST00000266397.2	-	2	729	c.156C>T	c.(154-156)ttC>ttT	p.F52F		NM_152321.2	NP_689534.1	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27	52	Thioredoxin.		F -> L (in dbSNP:rs35030722).			endoplasmic reticulum lumen				breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(3)|prostate(2)|skin(1)	19						TGGCAGCAATGAATTCCATGG	0.522000													12	154					0	0	1	0	0
PTBP2	58155	broad.mit.edu	37	1	97236339	97236339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:97236339C>T	ENST00000236228.6	+	5	446	c.364C>T	c.(364-366)Cgt>Tgt	p.R122C	PTBP2_ENST00000482253.1_3'UTR|PTBP2_ENST00000370198.1_Missense_Mutation_p.R122C|PTBP2_ENST00000541987.1_Missense_Mutation_p.R91C|PTBP2_ENST00000370197.1_Missense_Mutation_p.R122C|PTBP2_ENST00000394184.3_Missense_Mutation_p.R133C|PTBP2_ENST00000426398.2_Missense_Mutation_p.R122C	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	122	RRM 1.						nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		ACCTCATCTTCGTAACCAACC	0.338000													20	115					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2818707	2818707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2818707C>T	ENST00000520002.1	-	63	10216	c.9661G>A	c.(9661-9663)Ggt>Agt	p.G3221S	CSMD1_ENST00000542608.1_Missense_Mutation_p.G3043S|CSMD1_ENST00000537824.1_Missense_Mutation_p.G3220S|CSMD1_ENST00000602723.1_Missense_Mutation_p.G3044S|CSMD1_ENST00000400186.3_Missense_Mutation_p.G3044S|CSMD1_ENST00000602557.1_Missense_Mutation_p.G3221S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3221	Sushi 27.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTGGCGTACCAGGGTCTGGG	0.353000													8	28					0	0	1	0	0
USO1	8615	broad.mit.edu	37	4	76650013	76650013	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76650013C>A	ENST00000538159.1	+	1	10	c.10C>A	c.(10-12)Ctc>Atc	p.L4I	USO1_ENST00000514213.2_Missense_Mutation_p.L4I			O60763	USO1_HUMAN	USO1 vesicle transport factor	4	Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GATGAATTTCCTCCGCGGGGT	0.642000													6	41					0.00307968	0.00308211	1	1	0
TRAV13-1	28671	broad.mit.edu	37	14	22337337	22337337	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22337337C>T	ENST00000390436.2	+	0	151																											ATCAAGTGTACTTATTCAGAC	0.438000													53	103					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573509	140573509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140573509G>A	ENST00000239446.4	+	1	1568	c.1384G>A	c.(1384-1386)Gag>Aag	p.E462K		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		462	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGTCCGCGAGAACAACAG	0.627000													65	185					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584053	179584053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179584053C>T	ENST00000589042.1	-	83	24288	c.24064G>A	c.(24064-24066)Gga>Aga	p.G8022R	TTN_ENST00000342992.6_Missense_Mutation_p.G6778R|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G7705R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7705	Ig-like 62.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCATTTCCATCCTGAAAC	0.512000													61	123					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90435980	90435980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90435980G>A	ENST00000394375.3	+	10	1046	c.933G>A	c.(931-933)ggG>ggA	p.G311G	LIPF_ENST00000238983.4_Silent_p.G301G|LIPF_ENST00000496797.1_3'UTR|LIPF_ENST00000355843.2_Silent_p.G268G	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	301					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		TTAAGTCTGGGAAATTCCAAG	0.308000													12	51					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135203728	135203728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135203728G>A	ENST00000372169.2	-	10	3439	c.3257C>T	c.(3256-3258)tCa>tTa	p.S1086L	SETX_ENST00000393220.1_Missense_Mutation_p.S1086L|SETX_ENST00000224140.5_Missense_Mutation_p.S1086L			Q7Z333	SETX_HUMAN	senataxin	1086					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CACTTCAGATGAACTTTCAAA	0.348000													14	103					0	0	1	0	0
CRTAM	56253	broad.mit.edu	37	11	122738187	122738187	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:122738187C>T	ENST00000227348.4	+	8	935	c.888C>T	c.(886-888)ttC>ttT	p.F296F	CRTAM_ENST00000533709.1_Silent_p.F97F	NM_019604.2	NP_062550.2	O95727	CRTAM_HUMAN	cytotoxic and regulatory T cell molecule	296					cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TGGTGTCCTTCCTCATTTTCA	0.438000													12	43					0	0	1	0	0
OR5B2	390190	broad.mit.edu	37	11	58190468	58190468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58190468G>A	ENST00000302581.2	-	1	318	c.267C>T	c.(265-267)gtC>gtT	p.V89V		NM_001005566.2	NP_001005566.1	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B, member 2	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGTAGGAGATGACCTTGTCTC	0.488000													45	122					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109696929	109696929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:109696929C>T	ENST00000465301.2	+	3	3330	c.3084C>T	c.(3082-3084)tcC>tcT	p.S1028S	RGAG1_ENST00000540313.1_Silent_p.S1028S	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1028										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						GAGCAAGGTCCACATCATTTA	0.498000													61	47					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731956	140731956	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140731956G>T	ENST00000523390.1	+	1	2129	c.2129G>T	c.(2128-2130)cGc>cTc	p.R710L	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGCCCTGCGCCTGCGACGT	0.612000													38	185					2.35968e-33	2.37656e-33	1	1	0
GRIA1	2890	broad.mit.edu	37	5	153026600	153026600	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153026600G>A	ENST00000285900.5	+	3	676	c.333G>A	c.(331-333)ccG>ccA	p.P111P	GRIA1_ENST00000518783.1_Silent_p.P121P|GRIA1_ENST00000521843.2_Silent_p.P42P|GRIA1_ENST00000340592.5_Silent_p.P111P|GRIA1_ENST00000448073.4_Silent_p.P121P|GRIA1_ENST00000518862.1_3'UTR|GRIA1_ENST00000518142.1_Intron	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	111					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCATTACGCCGAGCTTTCCCG	0.493000													47	116					0	0	1	0	0
NCAPH2	29781	broad.mit.edu	37	22	50956060	50956060	+	Silent	SNP	C	C	T	rs150150677		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50956060C>T	ENST00000395701.3	+	4	415	c.321C>T	c.(319-321)agC>agT	p.S107S	NCAPH2_ENST00000395698.3_Silent_p.S107S|NCAPH2_ENST00000299821.11_Silent_p.S107S|NCAPH2_ENST00000420993.2_Silent_p.S107S			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	107					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		GGGTTGCCAGCTCCGGGGTCC	0.652000													26	74					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60370618	60370618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60370618C>T	ENST00000371204.3	-	7	1159	c.1116G>A	c.(1114-1116)atG>atA	p.M372I	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	372					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					TGATGTTGCCCATTCTCTGCA	0.557000													34	85					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160459991	160459991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160459991G>A	ENST00000368059.3	-	5	862	c.793C>T	c.(793-795)Ccc>Tcc	p.P265S	SLAMF6_ENST00000368055.1_Missense_Mutation_p.P154S|SLAMF6_ENST00000368057.3_Missense_Mutation_p.P265S	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	265						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TGCTCACCGGGGCCCTGTGTT	0.478000													35	120					0	0	1	0	0
HEXA	3073	broad.mit.edu	37	15	72640430	72640430	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72640430G>A	ENST00000268097.5	-	9	1535	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F	HEXA_ENST00000429918.2_Silent_p.F171F|RP11-106M3.2_ENST00000379915.4_RNA|RP11-106M3.3_ENST00000570175.1_RNA|HEXA_ENST00000566304.1_Silent_p.F355F|HEXA_ENST00000457859.2_Silent_p.F152F|HEXA_ENST00000567159.1_Silent_p.F344F	NM_000520.4	NP_000511.2	P06865	HEXA_HUMAN	hexosaminidase A (alpha polypeptide)	344					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(3)|kidney(3)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	24						AGTCCTCACCGAAGCCTTTCT	0.517000													21	82					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67629324	67629324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:67629324G>A	ENST00000335894.4	+	5	465	c.399G>A	c.(397-399)tcG>tcA	p.S133S	IQCH_ENST00000546225.1_5'UTR|IQCH_ENST00000358767.3_5'UTR	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	133										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		TAAAGGTTTCGAAGTTAATCA	0.343000													45	74					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150817106	150817106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150817106G>A	ENST00000370357.4	+	9	894	c.649G>A	c.(649-651)Gga>Aga	p.G217R		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	217						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTCAAAGAGGACACACTAG	0.408000													92	57					0	0	1	0	0
STAT6	6778	broad.mit.edu	37	12	57496103	57496103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57496103G>A	ENST00000300134.3	-	13	1807	c.1482C>T	c.(1480-1482)caC>caT	p.H494H	STAT6_ENST00000543873.2_Silent_p.H494H|STAT6_ENST00000556155.1_Silent_p.H494H|STAT6_ENST00000454075.3_Silent_p.H494H|STAT6_ENST00000538913.2_Silent_p.H384H|STAT6_ENST00000537215.2_Silent_p.H384H	NM_001178078.1|NM_003153.4	NP_001171549.1|NP_003144.3	P42226	STAT6_HUMAN	signal transducer and activator of transcription 6, interleukin-4 induced	494					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	28						ACACAGAACGGTGCTGGAAGG	0.597000													54	126					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18865911	18865911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18865911C>T	ENST00000266505.7	-	6	842	c.579G>A	c.(577-579)gtG>gtA	p.V193V	PLCZ1_ENST00000541695.1_Silent_p.V56V|PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000447925.2_Silent_p.V191V|PLCZ1_ENST00000538330.1_5'UTR|PLCZ1_ENST00000435379.1_Intron			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	193	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					GGCATCCTTTCACAAGGGCAC	0.348000													22	55					0	0	1	0	0
OR2B3	442184	broad.mit.edu	37	6	29054214	29054214	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29054214C>T	ENST00000377173.2	-	1	876	c.812G>A	c.(811-813)gGa>gAa	p.G271E		NM_001005226.2	NP_001005226.1			olfactory receptor, family 2, subfamily B, member 3											breast(1)|endometrium(1)|kidney(2)|lung(17)|prostate(1)|skin(2)	24						AACCATCTTTCCCCAGTCCTT	0.443000													9	63					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118293378	118293378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:118293378G>A	ENST00000425217.1	-	3	294	c.240C>T	c.(238-240)atC>atT	p.I80I	KSR2_ENST00000339824.5_Silent_p.I109I	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	109					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCCGGGGGAGATTTCCTAGA	0.602000													9	30					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3334455	3334455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3334455G>A	ENST00000378398.3	+	12	2837	c.2755G>A	c.(2755-2757)Ggc>Agc	p.G919S	PRDM16_ENST00000378391.2_Missense_Mutation_p.G919S|PRDM16_ENST00000270722.5_Missense_Mutation_p.G919S|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Missense_Mutation_p.G918S|PRDM16_ENST00000441472.2_Missense_Mutation_p.G918S|PRDM16_ENST00000514189.1_Missense_Mutation_p.G919S|PRDM16_ENST00000511072.1_Missense_Mutation_p.G920S			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	919	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GGCGGACTCGGGCAGCTCCCT	0.602000			T	EVI1	"""MDS, AML"""								38	112					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74978059	74978059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74978059C>T	ENST00000261978.4	-	19	3303	c.2917G>A	c.(2917-2919)Gaa>Aaa	p.E973K	LTBP2_ENST00000556690.1_Missense_Mutation_p.E973K	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	973	Cys-rich.|EGF-like 7; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TGACGGCATTCGTTGATATCT	0.572000													33	89					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660591	77660591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77660591C>T	ENST00000296043.6	+	5	2218	c.1265C>T	c.(1264-1266)tCc>tTc	p.S422F		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	422					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TCTTTAGGCTCCCTGAAGTCT	0.552000													25	56					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36897082	36897082	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36897082C>T	ENST00000301807.6	-	12	4246	c.2349G>A	c.(2347-2349)ggG>ggA	p.G783G	TRANK1_ENST00000429976.2_Silent_p.G1333G|TRANK1_ENST00000428977.2_Silent_p.G783G	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1333					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ACCGTTTCCTCCCTAATTTCT	0.428000													43	110					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99655719	99655719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99655719C>T	ENST00000370597.3	-	10	1595	c.1240G>A	c.(1240-1242)Gga>Aga	p.G414R	CRTAC1_ENST00000370591.2_Missense_Mutation_p.G414R|CRTAC1_ENST00000298819.4_Missense_Mutation_p.G414R	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	414						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		ATCCCGTCTCCGTCGAAGTCG	0.582000													6	68					0	0	1	0	0
GSR	2936	broad.mit.edu	37	8	30560722	30560722	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30560722G>A	ENST00000221130.5	-	5	618	c.528C>T	c.(526-528)ttC>ttT	p.F176F	GSR_ENST00000546342.1_Silent_p.F176F|GSR_ENST00000537535.1_Silent_p.F176F|GSR_ENST00000414019.1_Silent_p.F133F|GSR_ENST00000541648.1_Silent_p.F176F	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	176					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	GATCACTCGTGAAGGCTGCAT	0.483000													38	88					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24392293	24392293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24392293C>T	ENST00000329601.7	-	30	3790	c.3628G>A	c.(3628-3630)Ggg>Agg	p.G1210R	MYOM3_ENST00000338909.5_Intron|MYOM3_ENST00000374434.3_Intron|MYOM3_ENST00000330966.7_Intron|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	0										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		agcctcggccctgCCCTGACT	0.498000													4	30					0	0	1	0	0
OVCH2	341277	broad.mit.edu	37	11	7723765	7723765	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7723765G>A	ENST00000454689.1	-	0	401				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GTTTCTTGGTGGAGAAATGTG	0.418000													16	19					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28537605	28537605	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:28537605G>A	ENST00000401766.2	-	10	1889	c.1377C>T	c.(1375-1377)gcC>gcT	p.A459A	SLC6A4_ENST00000261707.3_Silent_p.A459A			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	459					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CCCGGCGCTTGGCCCAGACGT	0.587000													8	73					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870386	51870386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51870386C>T	ENST00000371497.5	+	2	1276	c.389C>T	c.(388-390)gCc>gTc	p.A130V	TSHZ2_ENST00000329613.6_Missense_Mutation_p.A127V|TSHZ2_ENST00000603338.2_Missense_Mutation_p.A127V	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	130					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			GCTGTCTACGCCAACATCCTG	0.527000													19	50					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228137704	228137704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228137704G>A	ENST00000396578.3	+	26	1960	c.1798G>A	c.(1798-1800)Gat>Aat	p.D600N	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	600	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TCCTCCAGGGGATCCTGGCTC	0.567000													22	58					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306918	54306918	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54306918G>A	ENST00000545554.1	+	1	1818	c.1818G>A	c.(1816-1818)ttG>ttA	p.L606L	UNC13C_ENST00000537900.1_Silent_p.L606L|UNC13C_ENST00000260323.11_Silent_p.L606L			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	606					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ACCAGCATTTGAATGGAGGTG	0.502000													16	99					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125175031	125175031	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125175031A>G	ENST00000431078.1	+	4	757	c.393A>G	c.(391-393)ggA>ggG	p.G131G		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	131	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCTTTGCAGGAAACATGAATG	0.488000													8	26					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175576	143175576	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143175576T>A	ENST00000408916.1	+	1	611	c.611T>A	c.(610-612)aTt>aAt	p.I204N	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	204					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					ATGCTGTTAATTAATTCTCTG	0.463000													24	51					0	0	1	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242741358	242741358	+	Silent	SNP	C	C	T	rs140456342		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242741358C>T	ENST00000192314.6	+	3	413	c.282C>T	c.(280-282)taC>taT	p.Y94Y		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	94					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		ACCTGGGCTACCCCTGGCTCT	0.657000													23	49					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333557	70333557	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70333557C>T	ENST00000338508.4	-	32	2843	c.2844G>A	c.(2842-2844)gaG>gaA	p.E948E	SHANK2_ENST00000449833.2_Silent_p.E352E|SHANK2_ENST00000423696.2_Silent_p.E568E|SHANK2_ENST00000409161.1_Silent_p.E351E			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	568					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACATCCCCTTCTCCCTCATCA	0.577000													21	39					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57078909	57078909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57078909G>A	ENST00000316981.3	-	5	1875	c.1396C>T	c.(1396-1398)Cct>Tct	p.P466S	PLAG1_ENST00000429357.2_Missense_Mutation_p.P466S|PLAG1_ENST00000423799.2_Missense_Mutation_p.P384S	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	466	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Massively activates transcription.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GTGTTTGCAGGATCCTGAAGA	0.498000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								25	165					0	0	1	0	0
NARS2	79731	broad.mit.edu	37	11	78147847	78147847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78147847G>A	ENST00000281038.5	-	14	1678	c.1303C>T	c.(1303-1305)Cgt>Tgt	p.R435C	NARS2_ENST00000528850.1_Missense_Mutation_p.R208C|RP11-452H21.1_ENST00000534168.1_RNA	NM_001243251.1|NM_024678.5	NP_001230180.1|NP_078954.4	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial (putative)	435					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding	p.R435C(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)	27	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CCAAATCGACGAAGGTCCAGA	0.358000													68	171					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51562352	51562352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:51562352G>A	ENST00000298239.6	+	3	223	c.191G>A	c.(190-192)aGa>aAa	p.R64K	MSMB_ENST00000358559.2_Silent_p.E99E	NM_138634.2	NP_619540.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	0						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						TCGTGGTGGAGAAGAAGGACC	0.463000													59	130					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254947	51254947	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:51254947G>A	ENST00000404971.1	-	2	1804	c.465C>T	c.(463-465)gtC>gtT	p.V155V	NRXN1_ENST00000405581.1_Silent_p.V155V|NRXN1_ENST00000402717.3_Silent_p.V155V|NRXN1_ENST00000401669.2_Silent_p.V155V|NRXN1_ENST00000406859.3_Silent_p.V155V|NRXN1_ENST00000405472.3_Silent_p.V155V|NRXN1_ENST00000406316.2_Silent_p.V155V	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	155	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCAGCCCCCCGACGAAAAGGC	0.662000													10	24					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443930	5443930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5443930G>A	ENST00000300778.4	+	1	590	c.500G>A	c.(499-501)cGa>cAa	p.R167Q	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTACTCAAGCGACTGCCTTTC	0.517000													106	226					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49918253	49918253	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49918253G>A	ENST00000447857.3	+	17	1579	c.1374_splice	c.e17+1	p.T458_splice		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	458						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						GCCAGGTCACGGTAGGCAGTC	0.592000													11	17					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126132960	126132960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126132960C>T	ENST00000393425.1	+	4	262	c.163C>T	c.(163-165)Cac>Tac	p.H55Y	CCDC37_ENST00000505024.1_Missense_Mutation_p.H55Y|CCDC37_ENST00000510833.1_Missense_Mutation_p.H55Y|CCDC37_ENST00000352312.1_Missense_Mutation_p.H55Y			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	55										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		GAACCCTTTCCACTTATCTGG	0.567000													90	300					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432511	140432511	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140432511C>T	ENST00000306549.3	+	1	1533	c.1456C>T	c.(1456-1458)Caa>Taa	p.Q486*		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		486	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAGAATGCCCAAATAACATA	0.423000													13	55					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075418	76075418	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:76075418G>A	ENST00000395215.3	+	0	1058																											GAGGCTTCGGGAGCAGCAGAA	0.607000													146	174					0	0	1	0	0
RRP9	9136	broad.mit.edu	37	3	51969369	51969369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51969369G>A	ENST00000232888.6	-	10	1033	c.960C>T	c.(958-960)ttC>ttT	p.F320F		NM_004704.3	NP_004695.1	O43818	U3IP2_HUMAN	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	320					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|skin(1)	21				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		GGTGGCCATAGAAGACAAGCT	0.652000													15	26					0	0	1	0	0
BARX2	8538	broad.mit.edu	37	11	129321287	129321287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:129321287C>T	ENST00000281437.4	+	4	926	c.830C>T	c.(829-831)cCa>cTa	p.P277L	BARX2_ENST00000526127.1_Missense_Mutation_p.P132L|BARX2_ENST00000531946.1_Missense_Mutation_p.P155L	NM_003658.4	NP_003649.2	Q9UMQ3	BARX2_HUMAN	BARX homeobox 2	277										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	20	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		GAACCCCCACCATTAAGCTAA	0.542000													25	65					0	0	1	0	0
RASL12	51285	broad.mit.edu	37	15	65347440	65347440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65347440C>T	ENST00000220062.4	-	5	874	c.598G>A	c.(598-600)Gag>Aag	p.E200K	RASL12_ENST00000434605.2_Missense_Mutation_p.E189K|RASL12_ENST00000421977.3_Missense_Mutation_p.E181K	NM_016563.2	NP_057647.1	Q9NYN1	RASLC_HUMAN	RAS-like, family 12	200					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			lung(1)|ovary(1)|skin(1)|urinary_tract(1)	4						GCCCTCTCCTCGGAGATGAAG	0.662000													12	21					0	0	1	0	0
DCST2	127579	broad.mit.edu	37	1	155004051	155004051	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155004051G>A	ENST00000368424.3	-	4	796	c.739_splice	c.e4+1	p.S246_splice	DCST2_ENST00000295536.5_Splice_Site_p.S246_splice	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	246						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTTTCTCACGGCTGGCAAGTC	0.602000													26	59					0	0	1	0	0
KATNAL2	83473	broad.mit.edu	37	18	44584634	44584634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44584634C>T	ENST00000245121.5	+	4	339	c.145C>T	c.(145-147)Ccc>Tcc	p.P49S	KATNAL2_ENST00000356157.7_Missense_Mutation_p.P121S|KATNAL2_ENST00000592005.1_Intron	NM_031303.2	NP_112593.2	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	121	LisH.					cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			central_nervous_system(2)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	27						TCAAAATCTTCCCAAGATCAA	0.458000													32	71					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52591937	52591937	+	Silent	SNP	C	C	T	rs139421363		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:52591937C>T	ENST00000395961.3	-	8	1339	c.1173G>A	c.(1171-1173)gcG>gcA	p.A391A	BCAS1_ENST00000434986.2_Intron|BCAS1_ENST00000371440.3_Intron|BCAS1_ENST00000371435.2_Silent_p.A391A	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	391						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CATTCTCCTCCGCACCTGTGG	0.413000													11	32					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56549453	56549453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56549453C>T	ENST00000390649.3	+	10	2678	c.2678C>T	c.(2677-2679)tCc>tTc	p.S893F		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	893						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTTACGACCTCCCCCAGCCTG	0.552000													12	59					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75325210	75325210	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75325210T>G	ENST00000556489.2	-	2	1312	c.1313A>C	c.(1312-1314)gAg>gCg	p.E438A	PROX2_ENST00000445876.1_Splice_Site_p.E438_splice|PROX2_ENST00000556084.2_Intron	NM_001243007.1	NP_001229936.1	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	438					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GTTTAGACCCTCCTGGATTTA	0.383000													7	7					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189912956	189912956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189912956C>T	ENST00000374866.3	-	45	3454	c.3180G>A	c.(3178-3180)cgG>cgA	p.R1060R		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1060					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CAGCACCATCCCGTCCTGGGG	0.348000													22	55					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15973617	15973617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:15973617G>A	ENST00000268712.3	-	31	4632	c.4375C>T	c.(4375-4377)Ctt>Ttt	p.L1459F	NCOR1_ENST00000395857.3_Missense_Mutation_p.L43F|NCOR1_ENST00000395851.1_Missense_Mutation_p.L1475F	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1459	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTGGACCTAAGAACGGAGGGG	0.522000													46	113					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30704350	30704350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30704350C>T	ENST00000256246.2	-	1	2258	c.2184G>A	c.(2182-2184)ggG>ggA	p.G728G		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	728										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTTCCATCTCCCCGTTATCAA	0.388000													16	129					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28284008	28284008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28284008C>T	ENST00000305242.5	-	2	156	c.64G>A	c.(64-66)Gaa>Aaa	p.E22K		NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	22							binding	p.E22K(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GGGGTGATTTCGAGGATTCCA	0.453000													19	53					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110454763	110454763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110454763C>T	ENST00000506538.2	+	17	2590	c.2017C>T	c.(2017-2019)Cct>Tct	p.P673S	WDR36_ENST00000513710.2_Missense_Mutation_p.P673S	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	673					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TTCTATGTCTCCTACTGGAGA	0.373000													56	142					0	0	1	0	0
IL5RA	3568	broad.mit.edu	37	3	3118303	3118303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3118303C>T	ENST00000446632.2	-	10	1577	c.1003G>A	c.(1003-1005)Gaa>Aaa	p.E335K	IL5RA_ENST00000418488.2_Missense_Mutation_p.E240K|IL5RA_ENST00000445864.2_Missense_Mutation_p.E126K|IL5RA_ENST00000438560.1_Missense_Mutation_p.E335K|IL5RA_ENST00000256452.3_Missense_Mutation_p.E335K	NM_175726.3	NP_783853.1	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha	335					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	24				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		GGCTTGTGTTCATCATTTCCT	0.373000													8	51					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38959746	38959746	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38959746C>T	ENST00000355481.4	+	26	3653	c.3522C>T	c.(3520-3522)tcC>tcT	p.S1174S	RYR1_ENST00000360985.3_Silent_p.S1174S|RYR1_ENST00000359596.3_Silent_p.S1174S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1174	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACTCAGGCTCCGAAACAGCCT	0.562000													24	65					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15646222	15646222	+	Silent	SNP	G	G	A	rs45604340		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15646222G>A	ENST00000378076.3	-	20	2456	c.2103C>T	c.(2101-2103)atC>atT	p.I701I	ITGA8_ENST00000477064.1_5'UTR	NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	701					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	p.I701I(1)		NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TGTTGCGTTCGATTCCAACAT	0.378000													32	85					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634267	70634267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70634267C>T	ENST00000381269.2	-	2	1626	c.873G>A	c.(871-873)atG>atA	p.M291I	SLC8A3_ENST00000534137.1_Missense_Mutation_p.M291I|SLC8A3_ENST00000528359.1_Missense_Mutation_p.M291I|SLC8A3_ENST00000356921.2_Missense_Mutation_p.M291I|SLC8A3_ENST00000357887.3_Missense_Mutation_p.M291I	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	291					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GGGAATTCATCATTTTCCCAT	0.478000													28	45					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066477	73066477	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73066477G>A	ENST00000429829.1	-	0	6111					NR_001564.2																						GGTCTTATGGGGTGGGCACTT	0.468000													31	17					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872865	55872865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55872865C>T	ENST00000313503.1	+	1	347	c.347C>T	c.(346-348)tCc>tTc	p.S116F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TACCTTCTCTCCTCAATGGCC	0.463000										HNSCC(53;0.14)			103	299					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13092387	13092387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:13092387C>T	ENST00000506447.1	+	34	6195	c.6115C>T	c.(6115-6117)Ccc>Tcc	p.P2039S	CEP192_ENST00000430049.2_Missense_Mutation_p.P1564S|CEP192_ENST00000325971.8_Missense_Mutation_p.P1443S|CEP192_ENST00000540847.2_3'UTR	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1634										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ATATGATCTTCCCCAACGACC	0.308000													18	49					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159660564	159660564	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159660564C>T	ENST00000297267.9	+	14	4396	c.4196C>T	c.(4195-4197)cCc>cTc	p.P1399L	FNDC1_ENST00000340366.6_Missense_Mutation_p.P1336L	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1399						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GAAGGGACCCCCGTGGTGAGT	0.483000													4	6					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89524656	89524656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89524656C>T	ENST00000370473.4	-	5	718	c.499G>A	c.(499-501)Gat>Aat	p.D167N		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	167					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCAGCTGAATCCTCAACCTCA	0.453000													40	74					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096686	167096686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167096686G>A	ENST00000361200.2	+	6	2484	c.2318G>A	c.(2317-2319)gGa>gAa	p.G773E	DUSP27_ENST00000271385.5_Missense_Mutation_p.G773E|DUSP27_ENST00000443333.1_Missense_Mutation_p.G773E|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	773					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						ATGCTTAGTGGACACAGCAGC	0.577000													15	84					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104025408	104025408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104025408G>A	ENST00000388887.2	+	6	724	c.520G>A	c.(520-522)Gga>Aga	p.G174R		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	174	EGF-like 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTGCAACAGTGGACTAGATGG	0.488000													39	153					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62178649	62178649	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62178649G>A	ENST00000217188.1	-	1	208	c.168C>T	c.(166-168)ttC>ttT	p.F56F		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	56	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			AGAGCGCAAGGAAGAGCTGAG	0.701000													6	20					0	0	1	0	0
ASRGL1	80150	broad.mit.edu	37	11	62123837	62123837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62123837G>A	ENST00000415229.2	+	3	446	c.231G>A	c.(229-231)atG>atA	p.M77I	ASRGL1_ENST00000535727.1_Intron|ASRGL1_ENST00000301776.5_Missense_Mutation_p.M77I	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	77					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	AGGTTGAAATGGATGCTAGTA	0.448000													40	111					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28474625	28474625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28474625G>A	ENST00000261609.7	-	33	5209	c.5101C>T	c.(5101-5103)Cct>Tct	p.P1701S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1701					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATTCCCTCAGGAATAAGTCTT	0.383000													45	106					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38830179	38830179	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38830179C>T	ENST00000359357.3	+	42	5858	c.5604C>T	c.(5602-5604)gtC>gtT	p.V1868V	DNAH8_ENST00000449981.2_Silent_p.V2085V|DNAH8_ENST00000441566.1_Silent_p.V1868V					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AATATGTGGTCGTGTTCAATT	0.423000													43	129					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361655	107361655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107361655G>A	ENST00000374779.2	-	1	133	c.40C>T	c.(40-42)Ctg>Ttg	p.L14L		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						AGTCCCTTCAGAAAAAATTCC	0.383000													24	91					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72286851	72286851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72286851G>A	ENST00000356056.5	-	10	2018	c.1546C>T	c.(1546-1548)Cat>Tat	p.H516Y	MYO9A_ENST00000566885.1_Missense_Mutation_p.H111Y|MYO9A_ENST00000424560.1_Missense_Mutation_p.H516Y|MYO9A_ENST00000563542.1_5'UTR|RP11-390D11.1_ENST00000568391.1_RNA|MYO9A_ENST00000564571.1_Missense_Mutation_p.H516Y|MYO9A_ENST00000444904.1_Missense_Mutation_p.H497Y	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	516	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AGAAGTGCATGATTAATTCGA	0.338000													52	123					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	63974589	63974589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:63974589G>A	ENST00000324472.4	-	19	1936	c.1753C>T	c.(1753-1755)Cgt>Tgt	p.R585C	DPY19L2_ENST00000413230.2_Missense_Mutation_p.R32C	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	585					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TTCTCAAAACGAACTCTGCGA	0.358000													13	59					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18767566	18767566	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18767566T>G	ENST00000304081.4	-	3	312	c.212A>C	c.(211-213)aAg>aCg	p.K71T	NT5C1B_ENST00000460052.1_5'UTR|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.K131T|NT5C1B_ENST00000600945.1_Missense_Mutation_p.K131T|NT5C1B_ENST00000359846.2_Missense_Mutation_p.K131T	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GGATGGAGCCTTGGTGGATGG	0.468000													30	89					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5744379	5744379	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5744379G>A	ENST00000356134.5	-	18	1829	c.1758C>T	c.(1756-1758)ctC>ctT	p.L586L	ANO2_ENST00000327087.8_Silent_p.L585L|ANO2_ENST00000546188.1_Silent_p.L586L	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	590						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GGATGACCACGAGGTTGATGA	0.532000													5	18					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11216169	11216169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11216169C>T	ENST00000558518.1	+	4	774	c.587C>T	c.(586-588)cCc>cTc	p.P196L	LDLR_ENST00000455727.2_Intron|LDLR_ENST00000558013.1_Missense_Mutation_p.P196L|LDLR_ENST00000545707.1_Intron|LDLR_ENST00000535915.1_Missense_Mutation_p.P155L|LDLR_ENST00000557933.1_Missense_Mutation_p.P196L	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	196	LDL-receptor class A 5.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GACAGTAGCCCCTGCTCGGCC	0.617000													26	50					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7847181	7847181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7847181G>A	ENST00000328375.1	-	1	338	c.339C>T	c.(337-339)ttC>ttT	p.F113F	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAGCCAGCAGGAAGCACTCGG	0.547000													38	111					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13701506	13701506	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13701506C>T	ENST00000265104.4	-	77	13482	c.13378G>A	c.(13378-13380)Gaa>Aaa	p.E4460K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4460					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCTATAAGTTCAGTAAACCAG	0.393000									Kartagener syndrome				16	109					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63851848	63851848	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:63851848C>T	ENST00000279873.7	+	10	3036	c.2626C>T	c.(2626-2628)Caa>Taa	p.Q876*	ARID5B_ENST00000309334.5_Nonsense_Mutation_p.Q633*	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	876					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CCACAGACACCAAGAAAAGCT	0.483000													37	113					0	0	1	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998398	8998398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8998398G>A	ENST00000310455.3	-	2	914	c.764C>T	c.(763-765)tCc>tTc	p.S255F	PPP1R3B_ENST00000519699.1_Missense_Mutation_p.S255F	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	255					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		CTGGTCAAAGGATATTCCCAA	0.498000													12	70					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256494	63256494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:63256494C>T	ENST00000323865.3	-	1	1286	c.1053G>A	c.(1051-1053)atG>atA	p.M351I	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	351					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGAAGGTGCCCATGATGATGC	0.597000													21	155					0	0	1	0	0
S100A3	6274	broad.mit.edu	37	1	153520175	153520175	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153520175G>A	ENST00000368713.3	-	3	485	c.289C>T	c.(289-291)Ccc>Tcc	p.P97S	S100A3_ENST00000368712.1_Missense_Mutation_p.P97S|S100A4_ENST00000368714.1_Intron	NM_002960.1	NP_002951.1	P33764	S10A3_HUMAN	S100 calcium binding protein A3	97							calcium ion binding|protein binding			breast(1)|liver(1)|lung(1)	3	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGCAGGGGGGCTCTGAGGGG	0.622000													27	83					0	0	1	0	0
WDR5	11091	broad.mit.edu	37	9	137007496	137007496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137007496C>T	ENST00000358625.3	+	6	567	c.396C>T	c.(394-396)gtC>gtT	p.V132V	WDR5_ENST00000425041.1_Silent_p.V132V	NM_017588.2	NP_060058.1	P61964	WDR5_HUMAN	WD repeat domain 5	132					histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	9		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		GTAATTATGTCTTTTGCTGCA	0.468000													30	74					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962038	10962038	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10962038G>A	ENST00000240691.2	-	1	729	c.637C>T	c.(637-639)Cga>Tga	p.R213*		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	213					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GCATGCAGTCGAATCTGCTTG	0.488000													19	51					0	0	1	0	0
IQCF1	132141	broad.mit.edu	37	3	51928921	51928921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51928921G>A	ENST00000310914.5	-	4	665	c.603C>T	c.(601-603)ttC>ttT	p.F201F		NM_152397.2	NP_689610.2	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	201										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCTTTATTGAGAAGGGAATAC	0.483000													14	61					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219423367	219423367	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219423367G>A	ENST00000258399.3	-	4	422	c.10C>T	c.(10-12)Ctg>Ttg	p.L4L	USP37_ENST00000418019.1_Silent_p.L4L|USP37_ENST00000454775.1_Silent_p.L4L|USP37_ENST00000338465.5_Silent_p.L4L|USP37_ENST00000415516.1_Intron	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	4					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TGTATCTTCAGAGGAGACATA	0.323000													50	113					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43918846	43918846	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43918846G>A	ENST00000261488.6	-	9	1441	c.864C>T	c.(862-864)tcC>tcT	p.S288S	ENOX1_ENST00000540032.1_Silent_p.S101S|ENOX1_ENST00000412891.1_Silent_p.S288S	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	288					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GTTCAATCCAGGAAAGCAGCA	0.458000													18	104					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10242054	10242054	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10242054G>A	ENST00000256458.4	+	3	369	c.277_splice	c.e3-1	p.W93_splice		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	93	Death.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						TGTTTTCAGGGAAACCGGCTC	0.478000													42	145					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40030593	40030593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40030593C>T	ENST00000336649.4	+	7	604	c.604C>T	c.(604-606)Ctc>Ttc	p.L202F	CACNA1I_ENST00000404898.1_Missense_Mutation_p.L202F|CACNA1I_ENST00000402142.3_Missense_Mutation_p.L202F|CACNA1I_ENST00000401624.1_Missense_Mutation_p.L202F|CACNA1I_ENST00000400164.3_Missense_Mutation_p.L202F|CACNA1I_ENST00000407673.1_Missense_Mutation_p.L202F			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	202					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGTGAACCTGCTCCTGGACAC	0.567000													61	209					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14748569	14748569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14748569G>A	ENST00000380881.4	-	32	6444	c.5629C>T	c.(5629-5631)Ctg>Ttg	p.L1877L	FREM1_ENST00000380894.1_Silent_p.L412L|FREM1_ENST00000422223.2_Silent_p.L1876L|FREM1_ENST00000380880.3_Silent_p.L1876L			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1876					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GGGGGCAGCAGATGCCAAATG	0.527000													51	164					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214727255	214727255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:214727255G>A	ENST00000331683.5	+	11	1212	c.1117G>A	c.(1117-1119)Gac>Aac	p.D373N	SPAG16_ENST00000374309.3_Missense_Mutation_p.D279N	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	373					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTGTGGCGAGGACCGACTCTG	0.502000													31	79					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102089764	102089764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102089764C>T	ENST00000318222.3	-	1	479	c.97G>A	c.(97-99)Ggg>Agg	p.G33R	PKD2L1_ENST00000338519.3_Missense_Mutation_p.G33R|PKD2L1_ENST00000353274.3_Missense_Mutation_p.G33R	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	33					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CTCAGCGTCCCGTGTGGGGAA	0.632000													39	73					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102290667	102290667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:102290667C>T	ENST00000370103.4	-	4	720	c.507G>A	c.(505-507)gaG>gaA	p.E169E	OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000338858.5_Silent_p.E189E|OLFM3_ENST00000536598.1_Silent_p.E94E|OLFM3_ENST00000359814.3_Silent_p.E189E	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	189						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CACCAATTTCCTCCTGAATAC	0.438000													9	52					0	0	1	0	0
LIN52	91750	broad.mit.edu	37	14	74562682	74562682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74562682C>T	ENST00000555028.1	+	3	305	c.138C>T	c.(136-138)ttC>ttT	p.F46F	LIN52_ENST00000554076.1_3'UTR	NM_001024674.2	NP_001019845.1	Q52LA3	LIN52_HUMAN	lin-52 homolog (C. elegans)	46										breast(1)|endometrium(2)|lung(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.00471)		CAGCTTCCTTCAAAAGTGTAA	0.313000													11	27					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72344498	72344498	+	Missense_Mutation	SNP	C	C	T	rs77006793	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:72344498C>T	ENST00000299687.5	+	1	1523	c.1523C>T	c.(1522-1524)cCt>cTt	p.P508L	ZNF407_ENST00000582337.1_Missense_Mutation_p.P508L|ZNF407_ENST00000577538.1_Missense_Mutation_p.P508L|ZNF407_ENST00000309902.6_Missense_Mutation_p.P508L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGTGCCCGTCCTCCGGACTCC	0.572000													37	95					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141734499	141734499	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141734499G>A	ENST00000475668.2	+	16	1871	c.1817G>A	c.(1816-1818)aGa>aAa	p.R606K	MGAM_ENST00000549489.2_Missense_Mutation_p.R606K			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	606	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.R606T(3)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCTAATAAGAGAAGCTTCATT	0.502000													9	32					0	0	1	0	0
ZNF200	7752	broad.mit.edu	37	16	3274511	3274511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3274511G>A	ENST00000431561.3	-	5	1181	c.569C>T	c.(568-570)tCc>tTc	p.S190F	ZNF200_ENST00000396868.3_Missense_Mutation_p.S189F|AJ003147.9_ENST00000576468.1_RNA|ZNF200_ENST00000396871.4_Missense_Mutation_p.S189F|ZNF200_ENST00000396870.4_Missense_Mutation_p.S189F|ZNF200_ENST00000414144.2_Missense_Mutation_p.S190F|ZNF200_ENST00000575948.1_Missense_Mutation_p.S189F	NM_001145447.1|NM_003454.3	NP_001138919.1|NP_003445.2	P98182	ZN200_HUMAN	zinc finger protein 200	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	17						AGAGACCAAGGAAGAATCCAT	0.398000													33	60					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647772	51647772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51647772G>A	ENST00000317643.6	+	2	612	c.543G>A	c.(541-543)atG>atA	p.M181I	SIGLEC7_ENST00000305628.7_Intron|SIGLEC7_ENST00000600577.1_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	181	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CGCCCCCTATGATCTCCTGGA	0.652000													45	165					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105353206	105353206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105353206C>T	ENST00000453495.1	+	12	2861	c.2633C>T	c.(2632-2634)cCc>cTc	p.P878L	CEP170B_ENST00000556508.1_Missense_Mutation_p.P807L|CEP170B_ENST00000418279.1_Missense_Mutation_p.P807L|CEP170B_ENST00000414716.3_Missense_Mutation_p.P877L					centrosomal protein 170B																		GCCAGTGGTCCCCCAGCGCCC	0.677000													15	47					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20565171	20565171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20565171C>T	ENST00000329697.6	-	5	836	c.668G>A	c.(667-669)gGg>gAg	p.G223E	ACSM2B_ENST00000565232.1_Missense_Mutation_p.G223E|ACSM2B_ENST00000565322.1_Missense_Mutation_p.G144E|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G223E	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	223					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						ACCACTGGTCCCACTAGTGAA	0.512000													11	89					0	0	1	0	0
MMP19	4327	broad.mit.edu	37	12	56235011	56235011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56235011C>T	ENST00000322569.4	-	3	274	c.183G>A	c.(181-183)caG>caA	p.Q61Q	MMP19_ENST00000548629.1_Silent_p.Q61Q|MMP19_ENST00000547487.1_5'UTR|MMP19_ENST00000409200.3_Silent_p.Q61Q	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	61					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						CAGATGCTTCCTGAAAAGCTC	0.527000													22	57					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73068427	73068427	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73068427G>A	ENST00000429829.1	-	0	4161					NR_001564.2																						CCTTTCTAATGGACAGGACTC	0.433000													9	5					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634419	70634419	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70634419A>G	ENST00000381269.2	-	2	1474	c.721T>C	c.(721-723)Ttt>Ctt	p.F241L	SLC8A3_ENST00000534137.1_Missense_Mutation_p.F241L|SLC8A3_ENST00000528359.1_Missense_Mutation_p.F241L|SLC8A3_ENST00000356921.2_Missense_Mutation_p.F241L|SLC8A3_ENST00000357887.3_Missense_Mutation_p.F241L	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	241					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CACACTGGAAAGAAGAAGAGA	0.483000													18	42					0	0	1	0	0
DNTTIP1	116092	broad.mit.edu	37	20	44420687	44420687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44420687G>A	ENST00000372622.3	+	1	112	c.44G>A	c.(43-45)gGg>gAg	p.G15E		NM_052951.2	NP_443183.1	Q9H147	TDIF1_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 1	15						nucleus				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9		Myeloproliferative disorder(115;0.0122)				GGACCTAGCGGGGCCGAGAGG	0.756000													4	11					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238256999	238256999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238256999C>T	ENST00000295550.4	-	30	7411	c.6959G>A	c.(6958-6960)gGa>gAa	p.G2320E	COL6A3_ENST00000409809.1_Missense_Mutation_p.G2114E|COL6A3_ENST00000472056.1_Missense_Mutation_p.G1713E|COL6A3_ENST00000346358.4_Missense_Mutation_p.G2120E|COL6A3_ENST00000353578.4_Missense_Mutation_p.G2114E|COL6A3_ENST00000347401.3_Missense_Mutation_p.G2119E	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2320	Collagen-like 5.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TACCTTTGGTCCTGGGTATCC	0.363000													36	98					0	0	1	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72958208	72958208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72958208G>A	ENST00000421285.3	+	16	1782	c.1782G>A	c.(1780-1782)caG>caA	p.Q594Q		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	594										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						GGCTGGCCCAGAAGGAGGAGG	0.627000													45	272					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132471171	132471171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:132471171C>T	ENST00000333577.4	+	7	2259	c.2150C>T	c.(2149-2151)tCc>tTc	p.S717F	EP400_ENST00000332482.4_Missense_Mutation_p.S644F|EP400_ENST00000389562.2_Missense_Mutation_p.S680F|EP400_ENST00000389561.2_Missense_Mutation_p.S681F|EP400_ENST00000330386.6_Missense_Mutation_p.S681F			Q96L91	EP400_HUMAN	E1A binding protein p400	717					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCAGGACCCTCCCCTGCTCGA	0.652000													41	55					0	0	1	0	0
C19orf57	79173	broad.mit.edu	37	19	14001207	14001207	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14001207G>A	ENST00000454313.1	-	6	520	c.462C>T	c.(460-462)ccC>ccT	p.P154P	C19orf57_ENST00000346736.2_Silent_p.P154P|C19orf57_ENST00000591586.1_Intron|C19orf57_ENST00000586783.1_Silent_p.P154P			Q0VDD7	CS057_HUMAN	chromosome 19 open reading frame 57	154					multicellular organismal development		protein binding			breast(2)|kidney(1)|lung(3)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CCTCCTGGAGGGGGACCCCCA	0.682000													22	48					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530017	140530017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140530017C>T	ENST00000231136.1	+	1	179	c.179C>T	c.(178-180)tCg>tTg	p.S60L	PCDHB6_ENST00000543635.1_Intron	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		60	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCTGGCTTCGCGGGGCGCT	0.507000													49	109					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176915071	176915071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176915071C>T	ENST00000367654.2	-	13	2277	c.2264G>A	c.(2263-2265)gGa>gAa	p.G755E	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.G747E|ASTN1_ENST00000367657.3_Missense_Mutation_p.G747E|ASTN1_ENST00000361833.2_Missense_Mutation_p.G747E			O14525	ASTN1_HUMAN	astrotactin 1	755					cell migration|neuron cell-cell adhesion	integral to membrane		p.Q743fs*11(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CCTGAATGTTCCTTTCAGCAC	0.438000													61	133					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227192761	227192761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:227192761G>A	ENST00000366769.3	-	34	6095	c.4804C>T	c.(4804-4806)Cca>Tca	p.P1602S	CDC42BPA_ENST00000334218.5_Missense_Mutation_p.P1664S|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.P1521S|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.P1615S|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.P1637S|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.P1574S|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.P1582S	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1615					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				GTGATAGATGGAATACTGACT	0.517000													28	99					0	0	1	0	0
PLOD2	5352	broad.mit.edu	37	3	145806495	145806495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:145806495G>A	ENST00000282903.5	-	9	1060	c.883C>T	c.(883-885)Cat>Tat	p.H295Y	PLOD2_ENST00000360060.3_Missense_Mutation_p.H295Y|RP11-274H2.2_ENST00000480247.1_RNA|PLOD2_ENST00000494950.1_Missense_Mutation_p.H240Y	NM_182943.2	NP_891988.1	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	295					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29					Vitamin C(DB00126)	ACGTTTGGATGGACCTTTGTT	0.308000													9	52					0	0	1	0	0
KDM5C	8242	broad.mit.edu	37	X	53223912	53223912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:53223912G>A	ENST00000452825.3	-	21	3778	c.3246C>T	c.(3244-3246)gcC>gcT	p.A1082A	KDM5C_ENST00000404049.3_Silent_p.A1148A|KDM5C_ENST00000375401.3_Silent_p.A1149A|KDM5C_ENST00000375383.3_Silent_p.A1108A|KDM5C_ENST00000375379.3_Silent_p.A1149A	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	1149					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CCTCCTTGAAGGCCACGATCT	0.612000			"""N, F, S"""		clear cell renal carcinoma								10	12					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23892849	23892849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23892849G>A	ENST00000355349.3	-	24	3168	c.3006C>T	c.(3004-3006)gcC>gcT	p.A1002A		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1002					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCTGTTGGTGGGCCTCTTGCA	0.537000													64	169					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681286	100681286	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100681286G>A	ENST00000306151.4	+	3	6653	c.6589G>A	c.(6589-6591)Gaa>Aaa	p.E2197K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2197	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAATTCTACTGAAGCCCGTTC	0.498000													205	508					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84456240	84456240	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84456240C>T	ENST00000416219.2	+	9	869	c.780C>T	c.(778-780)gtC>gtT	p.V260V	ATP2C2_ENST00000420010.2_3'UTR|ATP2C2_ENST00000262429.4_Silent_p.V260V			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	260					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						CACAGGGGGTCGTGATTGGAA	0.567000													47	245					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337662	102337662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:102337662C>T	ENST00000369138.1	+	11	2162	c.1672C>T	c.(1672-1674)Cct>Tct	p.P558S	GRIK2_ENST00000369137.3_Intron|GRIK2_ENST00000413795.1_Missense_Mutation_p.P558S|GRIK2_ENST00000318991.6_Missense_Mutation_p.P558S|GRIK2_ENST00000369134.4_Missense_Mutation_p.P509S|GRIK2_ENST00000421544.1_Missense_Mutation_p.P558S	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	558					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CTTCCTGAATCCTCTCTCCCC	0.448000													62	119					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83935804	83935804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83935804G>A	ENST00000345382.2	-	3	304	c.219C>T	c.(217-219)atC>atT	p.I73I	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Silent_p.I66I	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	73					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						ACATGGGGGGGATCCTTAGCT	0.423000													13	43					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168108280	168108280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168108280G>A	ENST00000409195.1	+	9	10467	c.10378G>A	c.(10378-10380)Gat>Aat	p.D3460N	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D3460N|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D3238N	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3285					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AACCTATGAGGATGTCATTGC	0.398000													16	44					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500731	90500731	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90500731C>T	ENST00000325643.5	+	4	1395	c.1329C>T	c.(1327-1329)ctC>ctT	p.L443L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		TCTGGGACCTCCCCTCTCTCA	0.562000													23	182					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96795611	96795611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96795611G>A	ENST00000342380.2	-	8	825	c.826C>T	c.(826-828)Ctc>Ttc	p.L276F		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	276					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						TAGAGTTTGAGGACCCGGGTG	0.647000													9	70					0	0	1	0	0
PDIA4	9601	broad.mit.edu	37	7	148703040	148703040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148703040G>A	ENST00000286091.4	-	8	1469	c.1237C>T	c.(1237-1239)Ccc>Tcc	p.P413S		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	413					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			ACCACCAGGGGGCGCCTGGTG	0.627000											OREG0018420	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	52					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37187987	37187987	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37187987C>T	ENST00000425901.2	+	0	1829					NR_033753.2																						GGTTGTAGCTCAACCTCCTGT	0.498000													10	24					0	0	1	0	0
ZNF155	7711	broad.mit.edu	37	19	44500820	44500820	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44500820C>T	ENST00000270014.2	+	5	939	c.811C>T	c.(811-813)Cat>Tat	p.H271Y	ZNF155_ENST00000407951.2_Missense_Mutation_p.H282Y|ZNF155_ENST00000590615.1_Missense_Mutation_p.H271Y	NM_001260487.1|NM_198089.2	NP_001247416.1|NP_932355.2	Q12901	ZN155_HUMAN	zinc finger protein 155	271						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				GGCCTTCATTCATGATTCCCA	0.393000													71	173					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218274	130218274	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130218274C>A	ENST00000276211.5	+	5	986	c.641C>A	c.(640-642)cCa>cAa	p.P214Q	ARHGAP36_ENST00000370921.1_Missense_Mutation_p.P78Q|ARHGAP36_ENST00000370922.1_Missense_Mutation_p.P202Q	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	214					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						ATTTCCTTTCCAATTGGCCAA	0.498000													4	38					0.00909568	0.00909849	1	1	0
PRDM8	56978	broad.mit.edu	37	4	81123333	81123333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:81123333C>T	ENST00000339711.4	+	10	1948	c.717C>T	c.(715-717)ccC>ccT	p.P239P	PRDM8_ENST00000504452.1_Silent_p.P239P|PRDM8_ENST00000415738.2_Silent_p.P239P	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	239	Gly-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						ACCCATCCCCCTCCCCGGAAA	0.667000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	33					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87967765	87967765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:87967765C>T	ENST00000369577.3	+	8	4461	c.4418C>T	c.(4417-4419)tCt>tTt	p.S1473F	ZNF292_ENST00000339907.4_Missense_Mutation_p.S1468F	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TTTCCTCGATCTGGTGTGACT	0.403000													7	34					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32256892	32256892	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32256892C>T	ENST00000360482.2	-	16	3092	c.2962_splice	c.e16-1	p.G988_splice	SPOCD1_ENST00000257100.3_Intron|SPOCD1_ENST00000373648.2_3'UTR|SPOCD1_ENST00000533231.1_Intron|RP11-84A19.3_ENST00000527035.1_RNA	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	988					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		AGCCCAAAGGCCTGCGGGGAA	0.582000													6	24					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33944535	33944535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33944535G>A	ENST00000379238.1	-	14	1490	c.1373C>T	c.(1372-1374)tCc>tTc	p.S458F	UBAP2_ENST00000379239.4_Missense_Mutation_p.S191F|UBAP2_ENST00000539807.1_Missense_Mutation_p.S213F|UBAP2_ENST00000379225.1_Missense_Mutation_p.S91F|UBAP2_ENST00000418786.2_Missense_Mutation_p.S405F|UBAP2_ENST00000449054.1_Missense_Mutation_p.S458F|UBAP2_ENST00000360802.1_Missense_Mutation_p.S458F			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	458										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GGAAGGAAAGGACTCCAAACC	0.512000													20	38					0	0	1	0	0
HLTF	6596	broad.mit.edu	37	3	148792128	148792128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:148792128G>A	ENST00000310053.5	-	4	596	c.403C>T	c.(403-405)Cct>Tct	p.P135S	HLTF_ENST00000465259.1_Missense_Mutation_p.P135S|HLTF_ENST00000392912.2_Missense_Mutation_p.P135S|HLTF_ENST00000494055.1_Missense_Mutation_p.P135S	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	135					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GCACCAAAAGGAACTACCCTA	0.338000													23	64					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234553868	234553868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:234553868G>A	ENST00000040877.1	-	22	3666	c.3667C>T	c.(3667-3669)Cct>Tct	p.P1223S		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1223					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			AGAAATTGAGGGAATTTATGA	0.284000													7	26					0	0	1	0	0
SLC35G1	159371	broad.mit.edu	37	10	95660812	95660812	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95660812C>T	ENST00000371408.3	+	3	721	c.660C>T	c.(658-660)caC>caT	p.H220H	SLC35G1_ENST00000427197.1_Silent_p.H221H			Q2M3R5	TMM20_HUMAN	solute carrier family 35, member G1	221						integral to membrane											ATTCAGGCCACCTTAAGGGAA	0.443000													36	56					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36181711	36181711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36181711C>T	ENST00000357641.6	+	8	2790	c.2537C>T	c.(2536-2538)tCc>tTc	p.S846F	BRPF3_ENST00000543502.1_Intron|BRPF3_ENST00000534400.1_Missense_Mutation_p.S846F|BRPF3_ENST00000443324.2_Intron|BRPF3_ENST00000339717.7_Intron|BRPF3_ENST00000534694.1_Intron	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	846					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						CCTGCACCTTCCTTGTCTGAG	0.493000													15	148					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64644340	64644340	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:64644340C>T	ENST00000371079.1	+	9	2991	c.2616C>T	c.(2614-2616)ccC>ccT	p.P872P	ROR1_ENST00000545203.1_Silent_p.P323P	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	872	Ser/Thr-rich.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						CTAGCTTGCCCTCATCAGGAT	0.507000													13	52					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53345298	53345298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:53345298C>T	ENST00000226067.5	+	2	775	c.302C>T	c.(301-303)cCa>cTa	p.P101L	HLF_ENST00000430986.2_Missense_Mutation_p.P16L|HLF_ENST00000573945.1_Missense_Mutation_p.P16L|HLF_ENST00000575345.1_Missense_Mutation_p.P16L	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	101					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						CCCCCCAGCCCATCTCAGCAT	0.577000			T	TCF3	ALL								58	145					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27460569	27460569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27460569C>T	ENST00000337929.3	+	9	2055	c.1582C>T	c.(1582-1584)Ccg>Tcg	p.P528S	IL21R_ENST00000395754.4_Missense_Mutation_p.P528S|IL21R_ENST00000564089.1_Missense_Mutation_p.P528S|IL21R-AS1_ENST00000563191.1_RNA|IL21R_ENST00000395755.1_Missense_Mutation_p.P528S	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	528					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						GGTCATTCCTCCGCCACTTTC	0.652000			T	BCL6	NHL								14	49					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27943722	27943722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27943722C>T	ENST00000374005.3	-	6	802	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	FGR_ENST00000399173.1_Missense_Mutation_p.E172K|FGR_ENST00000374004.1_Missense_Mutation_p.E172K|FGR_ENST00000545953.1_Intron	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	172	SH2.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GTCTCGCTTTCCCGAATGAGA	0.592000													30	61					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96609693	96609693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96609693C>T	ENST00000371321.3	+	8	1251	c.1169C>T	c.(1168-1170)tCc>tTc	p.S390F	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	390					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	ATATTAACTTCCCTCACTTCT	0.393000													78	166					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86124798	86124798	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86124798C>T	ENST00000394518.2	+	7	3594	c.3499C>T	c.(3499-3501)Cac>Tac	p.H1167Y	AKAP13_ENST00000361243.2_Missense_Mutation_p.H1167Y	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1167					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GGGAGCAGACCACAGCTGTAC	0.547000													46	55					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38924684	38924684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38924684G>A	ENST00000274276.3	+	14	2433	c.2031G>A	c.(2029-2031)aaG>aaA	p.K677K		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	677	Fibronectin type-III 4.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					GATTTGAAAAGGCAGTTCTTT	0.363000													43	115					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180003	124180003	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124180003G>A	ENST00000357821.2	-	1	730	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TGTAGAGGATGAAGGCATAGG	0.507000													16	32					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7473344	7473344	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7473344G>A	ENST00000399422.4	+	6	993	c.945G>A	c.(943-945)acG>acA	p.T315T		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	315					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						ATCCCATCACGACCCTGTGCA	0.463000													8	27					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135781419	135781419	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135781419G>A	ENST00000298552.3	-	15	1767	c.1546C>T	c.(1546-1548)Cag>Tag	p.Q516*	TSC1_ENST00000440111.2_Nonsense_Mutation_p.Q516*|TSC1_ENST00000545250.1_Nonsense_Mutation_p.Q465*	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	516					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.Q516*(2)|p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GTCTTCCGCTGAGAACCTGGG	0.567000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				14	39					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55733486	55733486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55733486G>A	ENST00000379906.2	+	11	1765	c.1510G>A	c.(1510-1512)Gac>Aac	p.D504N	SLC6A2_ENST00000566163.1_Missense_Mutation_p.D459N|SLC6A2_ENST00000414754.3_Missense_Mutation_p.D504N|SLC6A2_ENST00000561820.1_Missense_Mutation_p.D504N|SLC6A2_ENST00000568943.1_Missense_Mutation_p.D504N|SLC6A2_ENST00000219833.8_Missense_Mutation_p.D504N|SLC6A2_ENST00000567238.1_Missense_Mutation_p.D399N	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	504					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GTTCAGCAACGACATCCAGCA	0.592000													5	49					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50534962	50534962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50534962C>T	ENST00000267845.3	-	12	1886	c.1484G>A	c.(1483-1485)aGg>aAg	p.R495K	HDC_ENST00000543581.1_Missense_Mutation_p.R462K	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	495					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TCTGGCACCCCTGATTTGGGA	0.572000													16	42					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165948992	165948992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165948992C>T	ENST00000360093.3	-	27	5070	c.4579G>A	c.(4579-4581)Gtc>Atc	p.V1527I	SCN3A_ENST00000409101.3_Missense_Mutation_p.V1478I|SCN3A_ENST00000465043.1_5'UTR|SCN3A_ENST00000283254.7_Missense_Mutation_p.V1527I|SCN3A_ENST00000540861.1_Missense_Mutation_p.V10I	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1527						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ATATCAAAGACTTGTCTGGTT	0.383000													20	46					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24527904	24527904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24527904G>A	ENST00000342740.5	+	18	1562	c.1408G>A	c.(1408-1410)Gcc>Acc	p.A470T	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	470										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		TTCAGCGGGAGCCCAAGCCTT	0.592000											OREG0022615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	43					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46888190	46888190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46888190C>T	ENST00000359759.4	+	2	1407	c.1386C>T	c.(1384-1386)ctC>ctT	p.L462L	COL18A1_ENST00000355480.5_Silent_p.L227L|COL18A1_ENST00000400337.2_Silent_p.L47L			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	462	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TGCTGCAGCTCCTTGGGGACC	0.672000													29	71					0	0	1	0	0
THNSL1	79896	broad.mit.edu	37	10	25312259	25312259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25312259C>T	ENST00000524413.1	+	3	454	c.107C>T	c.(106-108)aCc>aTc	p.T36I	THNSL1_ENST00000376356.4_Missense_Mutation_p.T36I			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	36					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	CTTTCAAGAACCTTTGCACTT	0.388000													36	99					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168266990	168266990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168266990C>T	ENST00000367821.3	+	4	683	c.632C>T	c.(631-633)cCt>cTt	p.P211L		NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	211					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					AAGTACAATCCTTTTGCCAAA	0.338000													22	26					0	0	1	0	0
EXOSC10	5394	broad.mit.edu	37	1	11150690	11150690	+	Missense_Mutation	SNP	G	G	A	rs146582265	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11150690G>A	ENST00000544779.1	-	6	684	c.679C>T	c.(679-681)Cgt>Tgt	p.R227C	EXOSC10_ENST00000304457.7_Missense_Mutation_p.R227C|EXOSC10_ENST00000376936.4_Missense_Mutation_p.R227C			Q01780	EXOSX_HUMAN	exosome component 10	227					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		TCCTCAGGACGATCCTGTGGG	0.517000													14	32					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57070091	57070091	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57070091G>A	ENST00000532437.1	-	6	4836	c.4525C>T	c.(4525-4527)Ccg>Tcg	p.P1509S	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.P1509S			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1509	Acidic.|Tankyrase-binding.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				TCAGGCTGCGGCCTCCAGGAG	0.672000													4	26					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49176654	49176654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49176654G>A	ENST00000307885.4	-	1	1258	c.564C>T	c.(562-564)gcC>gcT	p.A188A	ADCY6_ENST00000357869.3_Silent_p.A188A|ADCY6_ENST00000550422.1_Silent_p.A188A	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	188					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CGAACAGGGCGGCGGCACAGG	0.667000													4	56					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63011984	63011984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:63011984C>T	ENST00000561311.1	+	24	3126	c.2896C>T	c.(2896-2898)Cct>Tct	p.P966S	TLN2_ENST00000306829.6_Missense_Mutation_p.P966S			Q9Y4G6	TLN2_HUMAN	talin 2	966	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TGATCACATCCCTCAGCTGGT	0.547000													23	15					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21478757	21478757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21478757G>A	ENST00000313654.9	+	45	5910	c.5669G>A	c.(5668-5670)gGc>gAc	p.G1890D	LAMA3_ENST00000587184.1_Missense_Mutation_p.G281D|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000269217.6_Missense_Mutation_p.G281D|LAMA3_ENST00000399516.3_Missense_Mutation_p.G1890D	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1890	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAATAGAAGGCCTGGAAAGA	0.348000													25	92					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151259552	151259552	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151259552T>A	ENST00000368879.2	+	2	883	c.785T>A	c.(784-786)tTc>tAc	p.F262Y		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	262	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGGGTGCCCTTCTTCAAGCAG	0.622000													31	124					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117297532	117297532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:117297532G>A	ENST00000369478.3	+	2	449	c.341G>A	c.(340-342)gGa>gAa	p.G114E	CD2_ENST00000369477.1_Missense_Mutation_p.G114E	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	114	Ig-like V-type.|LFA-3 (CD58) binding region 2.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GATACAAAAGGAAAAAATGTG	0.308000													7	45					0	0	1	0	0
LCOR	84458	broad.mit.edu	37	10	98715483	98715483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98715483C>T	ENST00000540664.1	+	8	1649	c.1106C>T	c.(1105-1107)tCc>tTc	p.S369F	LCOR_ENST00000356016.3_Missense_Mutation_p.S369F|LCOR_ENST00000498444.1_Intron|LCOR_ENST00000371097.4_Missense_Mutation_p.S369F|LCOR_ENST00000371103.3_Missense_Mutation_p.S369F	NM_001170765.1|NM_001170766.1	NP_001164236.1|NP_001164237.1			ligand dependent nuclear receptor corepressor											endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|urinary_tract(1)	13		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		ATGAGTGTTTCCAAAGCTCAG	0.438000													26	40					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22364037	22364037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22364037C>T	ENST00000397121.2	-	3	799	c.482G>A	c.(481-483)aGa>aAa	p.R161K		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGTATAAATTCTTTCATGTTG	0.338000													32	84					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136620245	136620245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136620245G>A	ENST00000264156.2	-	8	1212	c.1152C>T	c.(1150-1152)acC>acT	p.T384T	MCM6_ENST00000492091.1_5'UTR	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	384	MCM.			PKTTGEGTSLR -> SKDNRRRDLSS (in Ref. 2; AAC50766).	cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CTCGAAGAGAGGTCCCTTCTC	0.453000													52	116					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76342274	76342274	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76342274C>T	ENST00000312916.7	+	6	1355	c.973C>T	c.(973-975)Cat>Tat	p.H325Y		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	325					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		AATAGGCATTCATCACAAAAA	0.358000													17	215					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44378052	44378052	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44378052C>T	ENST00000587539.1	-	3	313	c.314G>A	c.(313-315)gGa>gAa	p.G105E	ZNF404_ENST00000324394.6_Missense_Mutation_p.G103E	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				ACTAAAACATCCCACTTTAGG	0.328000													40	148					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79341870	79341870	+	Missense_Mutation	SNP	C	C	T	rs150981409	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79341870C>T	ENST00000419573.3	-	4	866	c.592G>A	c.(592-594)Gat>Aat	p.D198N	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Missense_Mutation_p.D198N	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	198					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						CTGTCTTCATCGTTGGGGGCG	0.557000													13	69					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104075171	104075171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104075171G>A	ENST00000374874.3	+	6	1167	c.728G>A	c.(727-729)gGc>gAc	p.G243D	LPPR1_ENST00000395056.2_Missense_Mutation_p.G243D	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		243						integral to membrane	catalytic activity										TTCCTGACAGGCCTCAACCGG	0.547000													28	115					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141770881	141770881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141770881C>T	ENST00000475668.2	+	44	5203	c.5149C>T	c.(5149-5151)Ctg>Ttg	p.L1717L	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1717	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGGCTACATCCTGCCCTGGCA	0.493000													18	34					0	0	1	0	0
P2RX7	5027	broad.mit.edu	37	12	121593886	121593886	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121593886A>T	ENST00000546057.1	+	3	442	c.299A>T	c.(298-300)aAc>aTc	p.N100I	P2RX7_ENST00000541446.1_5'UTR|P2RX7_ENST00000377162.2_Missense_Mutation_p.N100I|P2RX7_ENST00000328963.5_5'UTR|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000535250.1_Missense_Mutation_p.N10I	NM_002562.5	NP_002553.3	A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	100						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCACAGGGGAACTCTTTCTTC	0.473000													39	95					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181752865	181752865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181752865C>T	ENST00000526775.1	+	39	5523	c.5358C>T	c.(5356-5358)ttC>ttT	p.F1786F	CACNA1E_ENST00000367567.4_Silent_p.F1412F|CACNA1E_ENST00000358338.5_Silent_p.F1737F|CACNA1E_ENST00000367570.1_Silent_p.F1805F|CACNA1E_ENST00000360108.3_Silent_p.F1786F|CACNA1E_ENST00000367573.2_Silent_p.F1805F|CACNA1E_ENST00000357570.5_Silent_p.F1756F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1805					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CGGTCCACTTCACCTCCACAC	0.443000													15	50					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88414169	88414169	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:88414169G>A	ENST00000261304.2	-	13	1498	c.1392C>T	c.(1390-1392)ttC>ttT	p.F464F	GALC_ENST00000393568.4_Silent_p.F441F|GALC_ENST00000393569.2_Silent_p.F438F|GALC_ENST00000544807.2_Silent_p.F408F	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	464					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TGGTGAGTGTGAACAGCTCAT	0.488000													23	73					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39510025	39510025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:39510025G>A	ENST00000537403.1	-	14	2649	c.1447C>T	c.(1447-1449)Ctg>Ttg	p.L483L	SEC23A_ENST00000536508.1_Silent_p.L583L|SEC23A_ENST00000307712.6_Silent_p.L685L|SEC23A_ENST00000545328.2_Silent_p.L656L			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	685					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		GGGGCTTGCAGAAGGTGGCGG	0.418000													22	89					0	0	1	0	0
ING3	54556	broad.mit.edu	37	7	120608053	120608053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120608053C>T	ENST00000315870.5	+	8	770	c.622C>T	c.(622-624)Ctg>Ttg	p.L208L	ING3_ENST00000431467.1_Silent_p.L193L	NM_019071.2	NP_061944.2	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3	208					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			NS(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	12	all_neural(327;0.117)					CTCCCAACCTCTGGGATCCTA	0.428000													25	55					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23239966	23239966	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23239966G>T	ENST00000400191.3	+	16	2882	c.2864G>T	c.(2863-2865)cGg>cTg	p.R955L	EPHB2_ENST00000374627.1_3'UTR|EPHB2_ENST00000374630.3_Missense_Mutation_p.R955L|EPHB2_ENST00000374632.3_Missense_Mutation_p.R956L	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	955	SAM.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GACATTCTCCGGGTTGGGGTC	0.552000													6	38					2.0095e-06	2.01378e-06	1	1	0
LILRA6	79168	broad.mit.edu	37	19	54746066	54746066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54746066C>T	ENST00000440558.2	-	3	239	c.191G>A	c.(190-192)gGa>gAa	p.G64E	LILRA6_ENST00000245621.5_Missense_Mutation_p.G64E|LILRA6_ENST00000419410.2_Missense_Mutation_p.G64E|LILRA6_ENST00000391735.3_Missense_Mutation_p.G64E|LILRB3_ENST00000407860.2_Missense_Mutation_p.G64E|LILRA6_ENST00000270464.5_Missense_Mutation_p.G64E|LILRA6_ENST00000396365.2_Missense_Mutation_p.G64E					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTCTGGGCTTCCCTCTTTATC	0.587000													79	355					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78328593	78328593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78328593C>T	ENST00000255189.3	-	9	1462	c.1434G>A	c.(1432-1434)ctG>ctA	p.L478L	DMGDH_ENST00000540686.1_Silent_p.L98L|DMGDH_ENST00000380311.4_Silent_p.L277L	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	478					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		ACTTAGACTCCAGCCTTTGAT	0.493000													35	191					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17449891	17449891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17449891G>A	ENST00000302539.4	-	14	2110	c.1985C>T	c.(1984-1986)cCa>cTa	p.P662L	ABCC8_ENST00000389817.3_Missense_Mutation_p.P662L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	662					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GCTCTGCAGTGGGCCGGTGAG	0.662000													31	91					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57367553	57367553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57367553G>A	ENST00000403558.1	+	2	721	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K	SERPING1_ENST00000278407.4_Missense_Mutation_p.E85K|SERPING1_ENST00000378323.4_Missense_Mutation_p.E90K|SERPING1_ENST00000340687.6_Missense_Mutation_p.E85K|SERPING1_ENST00000378324.2_Missense_Mutation_p.E33K	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	85	7 X 4 AA tandem repeats of [QE]-P-T-[TQ].		Missing (in HAE; type 2).		blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						taccactgatgaacccaccac	0.527000													6	27					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135369385	135369385	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:135369385C>T	ENST00000368517.3	-	10	648	c.510G>A	c.(508-510)ctG>ctA	p.L170L	SYCE1_ENST00000432597.2_Silent_p.L170L|SPRN_ENST00000541506.1_Intron|SYCE1_ENST00000343131.5_Silent_p.L206L	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	206					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TCACGTCTTCCAGTGTCGCCT	0.607000													17	30					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144944640	144944640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144944640C>T	ENST00000525985.1	-	2	2853	c.2782G>A	c.(2782-2784)Ggc>Agc	p.G928S				P58107	EPIPL_HUMAN	epiplakin 1	928						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTCCCAGGCCGCACAGGTAC	0.682000													7	28					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204944445	204944445	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204944445G>A	ENST00000367172.4	+	15	1933	c.1605G>A	c.(1603-1605)agG>agA	p.R535R	NFASC_ENST00000404076.1_Silent_p.R529R|NFASC_ENST00000513543.1_Silent_p.R546R|NFASC_ENST00000367171.4_Silent_p.R535R|NFASC_ENST00000403080.1_Silent_p.R535R|NFASC_ENST00000339876.6_Silent_p.R535R|NFASC_ENST00000539706.1_Silent_p.R546R|NFASC_ENST00000404907.1_Silent_p.R546R|NFASC_ENST00000360049.4_Silent_p.R546R|NFASC_ENST00000367170.4_Silent_p.R535R|NFASC_ENST00000401399.1_Silent_p.R535R|NFASC_ENST00000367169.4_Silent_p.R535R|NFASC_ENST00000338586.6_Silent_p.R535R|NFASC_ENST00000338515.6_Silent_p.R535R			O94856	NFASC_HUMAN	neurofascin	535	Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGGCCAGAAGGGGCACCACGG	0.622000											OREG0014142	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	104					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74414831	74414831	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:74414831G>A	ENST00000263665.6	-	8	996	c.969C>T	c.(967-969)ctC>ctT	p.L323L		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	323	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CATCCTTTATGAGTTGAACCC	0.398000													74	234					0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48165182	48165182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48165182C>T	ENST00000320031.8	+	24	3324	c.2994C>T	c.(2992-2994)gcC>gcT	p.A998A	ITGA3_ENST00000007722.7_Silent_p.A998A	NM_002204.2|NM_005501.2	NP_002195.1|NP_005492.1	P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	998					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						TGCTGGTGGCCGTGGGTGCAG	0.642000													7	11					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848186	215848186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215848186G>A	ENST00000366943.2	-	63	13453	c.13067C>T	c.(13066-13068)cCa>cTa	p.P4356L	USH2A_ENST00000307340.3_Missense_Mutation_p.P4356L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4356	Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GACTTCTGATGGAGCAGCCTC	0.498000										HNSCC(13;0.011)			15	82					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21478756	21478756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21478756G>A	ENST00000313654.9	+	45	5909	c.5668G>A	c.(5668-5670)Ggc>Agc	p.G1890S	LAMA3_ENST00000587184.1_Missense_Mutation_p.G281S|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000269217.6_Missense_Mutation_p.G281S|LAMA3_ENST00000399516.3_Missense_Mutation_p.G1890S	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1890	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAAATAGAAGGCCTGGAAAG	0.348000													25	91					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804214	115804214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115804214G>A	ENST00000369295.2	+	1	409	c.323G>A	c.(322-324)gGg>gAg	p.G108E		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	108					positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	CTGGTCATGGGGCTGCTGGTG	0.657000													38	75					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64825982	64825982	+	Silent	SNP	C	C	T	rs142141446		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64825982C>T	ENST00000358658.3	-	1	39	c.12G>A	c.(10-12)acG>acA	p.T4T	NAALADL1_ENST00000339885.2_Silent_p.T4T|NAALADL1_ENST00000356632.3_Silent_p.T4T|NAALADL1_ENST00000340252.4_Silent_p.T4T|NAALADL1_ENST00000355721.3_Silent_p.T4T|NAALADL1_ENST00000355369.2_Silent_p.T4T	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	4					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CCAACACCTTCGTCCACTGCA	0.592000													7	15					0	0	1	0	0
SHKBP1	92799	broad.mit.edu	37	19	41086272	41086272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41086272C>T	ENST00000291842.5	+	7	492	c.443C>T	c.(442-444)cCt>cTt	p.P148L	SHKBP1_ENST00000600733.1_Missense_Mutation_p.P148L	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	148						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTAGTGGGGCCTCAGCAGCTA	0.582000													13	41					0	0	1	0	0
CD226	10666	broad.mit.edu	37	18	67540457	67540457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:67540457G>A	ENST00000280200.4	-	5	1021	c.753C>T	c.(751-753)ctC>ctT	p.L251L	CD226_ENST00000581982.1_Silent_p.L96L|CD226_ENST00000582621.1_Silent_p.L251L|CD226_ENST00000577287.1_Silent_p.L96L	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	251					cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				CAGCCACAAAGAGGGTATATT	0.363000													63	137					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703723	4703723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4703723G>A	ENST00000396950.3	-	2	458	c.219C>T	c.(217-219)tcC>tcT	p.S73S		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGTGGATGTGGATAAGGCCA	0.502000													24	70					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142500312	142500312	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142500312C>T	ENST00000430863.1	-	0	682					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CACCACCCGCCACGAGTGCCT	0.652000													8	32					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103571339	103571339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103571339G>A	ENST00000380069.3	+	6	1472	c.1396G>A	c.(1396-1398)Gct>Act	p.A466T		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	466										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						GTTTGAAAAGGCTTTTCTGGC	0.657000											OREG0022947	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	60					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237863598	237863598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237863598G>A	ENST00000366574.2	+	65	9515	c.9198G>A	c.(9196-9198)gaG>gaA	p.E3066E	RYR2_ENST00000360064.6_Silent_p.E3064E|RYR2_ENST00000542537.1_Silent_p.E3050E	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3066					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACGCTGCAGAGGATCTGGAGA	0.483000													4	9					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59878805	59878805	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59878805G>A	ENST00000259008.2	-	8	1216	c.949C>T	c.(949-951)Cat>Tat	p.H317Y	BRIP1_ENST00000577598.1_Missense_Mutation_p.H317Y	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	317	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						CTAATTTTATGAACTCCATGA	0.368000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					21	165					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43314241	43314241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43314241C>T	ENST00000321925.4	+	5	576	c.344C>T	c.(343-345)tCa>tTa	p.S115L	SLC14A1_ENST00000502059.2_Missense_Mutation_p.S7L|SLC14A1_ENST00000586142.1_Missense_Mutation_p.S115L|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000436407.3_Missense_Mutation_p.S171L|SLC14A1_ENST00000402943.2_Missense_Mutation_p.S10L|RP11-116O18.3_ENST00000586213.1_RNA|SLC14A1_ENST00000535474.1_5'UTR|SLC14A1_ENST00000415427.3_Missense_Mutation_p.S171L|SLC14A1_ENST00000589700.1_Missense_Mutation_p.S115L|SLC14A1_ENST00000591943.1_3'UTR	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	115						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						CCCCACAGGTCATTAATAGCA	0.463000													48	112					0	0	1	0	0
RINT1	60561	broad.mit.edu	37	7	105190518	105190518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:105190518C>T	ENST00000257700.2	+	8	1244	c.1013C>T	c.(1012-1014)gCt>gTt	p.A338V		NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	338	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						TGGTACTTGGCTCAAGTACTT	0.348000													24	63					0	0	1	0	0
SH3BP2	6452	broad.mit.edu	37	4	2829023	2829023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:2829023C>T	ENST00000356331.5	+	6	756	c.495C>T	c.(493-495)tcC>tcT	p.S165S	SH3BP2_ENST00000515183.1_3'UTR|SH3BP2_ENST00000511747.1_Silent_p.S165S|SH3BP2_ENST00000503393.2_Silent_p.S222S|SH3BP2_ENST00000442312.2_Silent_p.S193S|SH3BP2_ENST00000435136.2_Silent_p.S165S|SH3BP2_ENST00000452765.2_Silent_p.S165S	NM_003023.4	NP_003014.3	P78314	3BP2_HUMAN	SH3-domain binding protein 2	165					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		TCAGCCTTTCCCCGTACCCCA	0.627000									Cherubism				23	58					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66075971	66075971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:66075971C>T	ENST00000349533.6	+	14	2172	c.1987C>T	c.(1987-1989)Ctt>Ttt	p.L663F	LEPR_ENST00000371058.1_Missense_Mutation_p.L663F|LEPR_ENST00000344610.8_Missense_Mutation_p.L663F|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371060.3_Missense_Mutation_p.L663F|LEPR_ENST00000371059.3_Missense_Mutation_p.L663F	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	663	Fibronectin type-III 3.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGTCACTTTACTTTGGAAGGT	0.284000													7	50					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198687314	198687314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:198687314C>T	ENST00000367376.2	+	14	1707	c.1536C>T	c.(1534-1536)ccC>ccT	p.P512P	PTPRC_ENST00000594404.1_Silent_p.P351P|PTPRC_ENST00000442510.2_Silent_p.P514P|PTPRC_ENST00000352140.3_Silent_p.P464P|PTPRC_ENST00000348564.6_Silent_p.P353P	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	512	Fibronectin type-III 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GTAATGGCCCCCATGAACGTT	0.428000													19	55					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92150276	92150276	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92150276C>T	ENST00000256343.3	-	11	1032	c.876G>A	c.(874-876)gtG>gtA	p.V292V		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	292					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GTTTTCCTTTCACATAGTCAA	0.259000													31	86					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42482862	42482862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42482862G>A	ENST00000545399.1	-	12	1718	c.1565C>T	c.(1564-1566)tCc>tTc	p.S522F	ATP1A3_ENST00000602133.1_Missense_Mutation_p.S479F|ATP1A3_ENST00000543770.1_Missense_Mutation_p.S520F|ATP1A3_ENST00000302102.5_Missense_Mutation_p.S509F	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	509					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CAGGATGGTGGAGCAGCGGTC	0.627000													43	86					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28260212	28260212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28260212C>T	ENST00000305242.5	-	8	1059	c.967G>A	c.(967-969)Gaa>Aaa	p.E323K	ARMC4_ENST00000239715.3_Missense_Mutation_p.E180K|ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000537576.1_Missense_Mutation_p.E15K|ARMC4_ENST00000545014.1_Intron	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	323							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TGATCCTTTTCCTTTTGCTGG	0.388000													21	53					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60702830	60702830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60702830C>T	ENST00000005286.4	+	10	2099	c.1946C>T	c.(1945-1947)tCg>tTg	p.S649L	TMEM132A_ENST00000453848.2_Missense_Mutation_p.S648L	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	648	Binds to HSPA5/GRP78 (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						ATGGGCATCTCGCTGACCTTG	0.662000													7	26					0	0	1	0	0
FBXW2	26190	broad.mit.edu	37	9	123550268	123550268	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123550268A>C	ENST00000373926.3	-	3	456	c.269T>G	c.(268-270)gTg>gGg	p.V90G	FBXW2_ENST00000340778.5_Missense_Mutation_p.V90G	NM_012164.3	NP_036296.2	Q9UKT8	FBXW2_HUMAN	F-box and WD repeat domain containing 2	90	F-box.				proteolysis		protein binding|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	4						GGCACTTATCACCTTATTCCA	0.443000													37	108					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68780337	68780337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68780337C>T	ENST00000508048.1	-	9	1096	c.1061G>A	c.(1060-1062)gGa>gAa	p.G354E	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.G355E|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.G358E			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	358	Peptidase S1.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TTCCATATATCCGGCACAGAA	0.368000													53	129					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89381960	89381960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89381960C>T	ENST00000439576.2	+	3	511	c.137C>T	c.(136-138)tCc>tTc	p.S46F	ACAN_ENST00000558207.1_Missense_Mutation_p.S46F|ACAN_ENST00000559004.1_Missense_Mutation_p.S46F|ACAN_ENST00000561243.1_Missense_Mutation_p.S46F|ACAN_ENST00000352105.7_Missense_Mutation_p.S46F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	46					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGGGACCTCCCTCACCATC	0.622000													37	118					0	0	1	0	0
CD8A	925	broad.mit.edu	37	2	87013055	87013055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:87013055C>T	ENST00000409511.2	-	9	1726	c.696G>A	c.(694-696)gcG>gcA	p.A232A	CD8A_ENST00000409781.1_Silent_p.A195A|CD8A_ENST00000538832.1_Silent_p.A273A|CD8A_ENST00000352580.3_Silent_p.A195A|CD8A_ENST00000456996.2_Silent_p.A195A|CD8A_ENST00000283635.3_Silent_p.A232A	NM_001145873.1	NP_001139345.1	P01732	CD8A_HUMAN	CD8a molecule	232					antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	8						AGACGTATCTCGCCGAAAGGC	0.507000													60	168					0	0	1	0	0
LINC00661	126536	broad.mit.edu	37	19	16131426	16131426	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16131426C>T	ENST00000549354.1	+	0	257				AC004790.3_ENST00000592886.1_lincRNA	NR_026828.1																						CATCAGTGCCCTGGAAGTGAA	0.627000													12	29					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130511741	130511741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130511741G>A	ENST00000314830.8	-	5	1001	c.888C>T	c.(886-888)ctC>ctT	p.L296L	SH2D3C_ENST00000429553.1_5'UTR|SH2D3C_ENST00000373274.3_Silent_p.L136L|SH2D3C_ENST00000420366.1_Silent_p.L138L|SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Silent_p.L139L|SH2D3C_ENST00000373276.3_Silent_p.L228L	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	296	SH2.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GATAGCGCACGAGGGCGGGCA	0.587000													7	59					0	0	1	0	0
STXBP4	252983	broad.mit.edu	37	17	53120603	53120603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:53120603C>T	ENST00000376352.2	+	11	1069	c.862C>T	c.(862-864)Cct>Tct	p.P288S	STXBP4_ENST00000405898.1_Missense_Mutation_p.P288S|STXBP4_ENST00000398391.2_Missense_Mutation_p.P213S|STXBP4_ENST00000299341.4_Missense_Mutation_p.P213S|STXBP4_ENST00000434978.2_Missense_Mutation_p.P288S	NM_178509.5	NP_848604.3	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	288						cytoplasm	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19						ATAGCTTCTTCCTTGTGATTC	0.323000													7	22					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89521887	89521887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89521887C>T	ENST00000370473.4	-	8	1399	c.1180G>A	c.(1180-1182)Gac>Aac	p.D394N		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	394					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TTACAAAAGTCATCCCGCTTT	0.393000													45	140					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113388767	113388767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113388767C>T	ENST00000228928.7	+	7	1823	c.1644C>T	c.(1642-1644)gcC>gcT	p.A548A	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	548	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						TGCTGCCTGCCTTCGATGCTG	0.597000													6	45					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52942138	52942138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52942138C>T	ENST00000332323.6	+	4	1525	c.1464C>T	c.(1462-1464)ttC>ttT	p.F488F	ZNF534_ENST00000433050.1_Silent_p.F475F|ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000432303.2_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						GCAAGGTCTTCAGTCAGAATT	0.418000													9	19					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55940302	55940302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55940302C>T	ENST00000244728.5	-	19	2283	c.1886G>A	c.(1885-1887)gGa>gAa	p.G629E	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.G29E|COL21A1_ENST00000535941.1_Missense_Mutation_p.G629E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G626E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	629	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TCCTTTTTTTCCTTGCTGTCC	0.353000													3	4					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55175726	55175726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55175726G>A	ENST00000421030.2	+	24	4123	c.3838G>A	c.(3838-3840)Ggg>Agg	p.G1280R	MROH7_ENST00000454855.2_Missense_Mutation_p.G798R|MROH7_ENST00000409996.1_Missense_Mutation_p.G848R|MROH7_ENST00000414150.2_Intron	NM_001039464.2	NP_001034553.2			maestro heat-like repeat family member 7																		GCTGCCGCACGGGAACTCATG	0.617000													9	50					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34004133	34004133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34004133G>A	ENST00000374181.3	-	8	1923	c.1754C>T	c.(1753-1755)tCg>tTg	p.S585L	GRM4_ENST00000535756.1_Missense_Mutation_p.S452L|GRM4_ENST00000374177.3_Missense_Mutation_p.S469L|GRM4_ENST00000538487.1_Missense_Mutation_p.S585L|GRM4_ENST00000545715.1_Missense_Mutation_p.S277L|GRM4_ENST00000455714.2_Missense_Mutation_p.S445L|GRM4_ENST00000544773.1_Missense_Mutation_p.S416L	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	585					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	GGCCCAGGGCGAGCCCCACTC	0.637000													12	20					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801863	185801863	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185801863A>C	ENST00000302277.6	+	4	2334	c.1740A>C	c.(1738-1740)atA>atC	p.I580I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	580						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						ACAACAAAATAAGGTTGAAAG	0.289000													24	65					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60359414	60359414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60359414G>A	ENST00000371204.3	-	9	1461	c.1418C>T	c.(1417-1419)cCc>cTc	p.P473L	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	473					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					ATTGTTTGGGGGCCTGAAGGT	0.463000													121	315					0	0	1	0	0
LGALS9	3965	broad.mit.edu	37	17	25967717	25967717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:25967717C>T	ENST00000395473.2	+	3	1719	c.251C>T	c.(250-252)cCc>cTc	p.P84L	AC015688.3_ENST00000584605.1_3'UTR|LGALS9_ENST00000448970.2_3'UTR|LGALS9_ENST00000413914.2_Missense_Mutation_p.P27L|LGALS9_ENST00000313648.6_Missense_Mutation_p.P84L|LGALS9_ENST00000302228.5_Missense_Mutation_p.P84L|LGALS9_ENST00000310394.5_Missense_Mutation_p.P84L	NM_009587.2	NP_033665.1	O00182	LEG9_HUMAN	lectin, galactoside-binding, soluble, 9	84	Beta-galactoside binding 1.|Galectin 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity			endometrium(3)|large_intestine(2)|lung(12)|skin(1)	18	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		AGCTGGGGGCCCGAGGAGAGG	0.547000													49	56					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37324718	37324718	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:37324718G>A	ENST00000373091.3	-	7	1111	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	GRIK3_ENST00000462621.1_5'UTR|GRIK3_ENST00000373093.4_Silent_p.F365F	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	365					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCTCCTTGATGAAGTTCATGA	0.617000													18	94					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7949293	7949293	+	Missense_Mutation	SNP	C	C	T	rs148940548	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7949293C>T	ENST00000309838.2	-	1	916	c.917G>A	c.(916-918)cGa>cAa	p.R306Q		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CACTCGCCTTCGCCATAATTT	0.373000													45	100					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145583669	145583669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145583669C>T	ENST00000532887.1	+	3	1100	c.517C>T	c.(517-519)Ccg>Tcg	p.P173S	SLC52A2_ENST00000329994.2_Missense_Mutation_p.P173S|SLC52A2_ENST00000402965.1_Missense_Mutation_p.P173S|SLC52A2_ENST00000527078.1_Missense_Mutation_p.P173S|SLC52A2_ENST00000540505.1_Missense_Mutation_p.P85S|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000530047.1_Missense_Mutation_p.P173S			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	173						integral to plasma membrane	receptor activity|riboflavin transporter activity										CCTCGAGTGCCCGCCAGCCCC	0.667000													21	100					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196636412	196636412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196636412G>A	ENST00000312428.6	-	61	11505	c.11405C>T	c.(11404-11406)tCg>tTg	p.S3802L	DNAH7_ENST00000409063.1_Missense_Mutation_p.S285L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3802					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATTTACGCACGAATCTCTTAT	0.358000													40	156					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148801858	148801858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148801858G>A	ENST00000378061.2	-	4	1237	c.1105C>T	c.(1105-1107)Cgg>Tgg	p.R369W		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	369					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GCAGCCTTCCGGGAGAAGCTC	0.577000													32	102					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26463032	26463032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26463032C>T	ENST00000265944.5	+	30	4005	c.3839C>T	c.(3838-3840)tCc>tTc	p.S1280F	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1280					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AATGAGACTTCCTTTAAAAAA	0.398000													16	40					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9560965	9560965	+	Silent	SNP	G	G	A	rs142086015		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9560965G>A	ENST00000378429.3	-	5	1363	c.817C>T	c.(817-819)Ctg>Ttg	p.L273L	PAK7_ENST00000378423.1_Silent_p.L273L|PAK7_ENST00000353224.5_Silent_p.L273L	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	273	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GTCTGATTCAGGTACGAAGAC	0.567000													35	90					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130511630	130511630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130511630G>A	ENST00000314830.8	-	5	1112	c.999C>T	c.(997-999)ggC>ggT	p.G333G	SH2D3C_ENST00000429553.1_5'UTR|SH2D3C_ENST00000373274.3_Silent_p.G173G|SH2D3C_ENST00000420366.1_Silent_p.G175G|SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Silent_p.G176G|SH2D3C_ENST00000373276.3_Silent_p.G265G	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	333					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CCTGTCCCAGGCCATAGCTGG	0.647000													5	63					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347305	57347305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57347305G>A	ENST00000361249.3	+	5	748	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	218	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GTACCACTTTGAAGTAAGTCT	0.473000													36	85					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919003	21919003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21919003C>T	ENST00000240662.2	-	3	1274	c.929G>A	c.(928-930)cGa>cAa	p.R310Q	RP11-59N23.1_ENST00000542489.1_RNA	NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	310						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	GTAGGAGGTTCGTGCTTGTGT	0.483000													21	76					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43048468	43048468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43048468G>A	ENST00000316099.3	+	7	933	c.844G>A	c.(844-846)Gat>Aat	p.D282N	HNF4A_ENST00000443598.2_Missense_Mutation_p.D282N|HNF4A_ENST00000457232.1_Missense_Mutation_p.D260N|HNF4A_ENST00000415691.1_Missense_Mutation_p.D282N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	282					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCTGCAGATCGATGACAATGA	0.567000													28	84					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152786560	152786560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152786560C>T	ENST00000367255.5	-	18	2366	c.1765G>A	c.(1765-1767)Gaa>Aaa	p.E589K	SYNE1_ENST00000466159.2_Missense_Mutation_p.E589K|SYNE1_ENST00000495090.2_Missense_Mutation_p.E156K|SYNE1_ENST00000341594.5_Missense_Mutation_p.E596K|SYNE1_ENST00000367248.3_Missense_Mutation_p.E579K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E596K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E596K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E589K|SYNE1_ENST00000413186.2_Missense_Mutation_p.E589K|SYNE1_ENST00000367253.4_Missense_Mutation_p.E589K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	589					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCGGTGGTTTCATTCATGAAT	0.398000										HNSCC(10;0.0054)			19	19					0	0	1	0	0
C6orf58	352999	broad.mit.edu	37	6	127901570	127901570	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:127901570G>A	ENST00000329722.7	+	3	561	c.549G>A	c.(547-549)atG>atA	p.M183I		NM_001010905.1	NP_001010905.1	Q6P5S2	CF058_HUMAN	chromosome 6 open reading frame 58	183						extracellular region				kidney(3)|large_intestine(3)|liver(1)|lung(7)|pancreas(1)	15				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		CTGAGACAATGAACAAGTGGA	0.398000													32	62					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112194227	112194227	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:112194227G>A	ENST00000455480.2	+	22	3400	c.3223G>A	c.(3223-3225)Gag>Aag	p.E1075K	RP11-162P23.2_ENST00000546840.2_Intron|ACAD10_ENST00000313698.4_Missense_Mutation_p.E1044K	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	1044							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CGGCCCTGACGAGGTGCACCG	0.647000													4	11					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104896	183104896	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:183104896C>T	ENST00000435564.1	-	3	539	c.339G>A	c.(337-339)gaG>gaA	p.E113E	PDE1A_ENST00000346717.4_Silent_p.E79E|PDE1A_ENST00000358139.2_Silent_p.E113E|PDE1A_ENST00000331935.6_Silent_p.E113E|PDE1A_ENST00000456212.1_Silent_p.E113E|PDE1A_ENST00000536095.1_Silent_p.E9E|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Silent_p.E113E|PDE1A_ENST00000409365.1_Silent_p.E97E|PDE1A_ENST00000351439.5_Silent_p.E97E	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	113					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTGGTTTTTCCTCAGGTTTCT	0.418000													31	112					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222307703	222307703	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:222307703G>A	ENST00000281821.2	-	11	1961	c.1920C>T	c.(1918-1920)ctC>ctT	p.L640L	EPHA4_ENST00000409938.1_Silent_p.L640L|EPHA4_ENST00000409854.1_Silent_p.L640L|EPHA4_ENST00000392071.4_Silent_p.L589L	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	640	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CAGGCACTTTGAGACGCCCAC	0.443000													42	104					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87025895	87025895	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87025895C>T	ENST00000370563.3	+	3	344	c.300_splice	c.e3-1	p.A101_splice	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	101						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CATTCTCAGGCTGATGTTATA	0.353000													31	81					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82580119	82580119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82580119G>A	ENST00000423517.2	-	6	10122	c.9785C>T	c.(9784-9786)tCt>tTt	p.S3262F	PCLO_ENST00000333891.8_Missense_Mutation_p.S3262F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3193					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.S3262Y(2)|p.S3193Y(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGCTTCATAGACTGCAGCTC	0.478000													13	135					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89256788	89256788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89256788C>T	ENST00000289746.2	+	8	1181	c.1116C>T	c.(1114-1116)ccC>ccT	p.P372P		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	372	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CCAACGAGCCCCCCGTGTTCC	0.677000													5	20					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65678963	65678963	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65678963G>A	ENST00000352385.2	-	17	3086	c.2877C>T	c.(2875-2877)atC>atT	p.I959I		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	959						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						CACCCACGATGATGCCCGTGA	0.637000											OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	18					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120510351	120510351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120510351C>T	ENST00000397558.2	+	6	1126	c.1126C>T	c.(1126-1128)Cgc>Tgc	p.R376C	CCDC64_ENST00000257583.4_Missense_Mutation_p.R25C|CCDC64_ENST00000446727.2_Intron	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	376					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGCCAGGTTCGCTATCTGTG	0.522000													16	99					0	0	1	0	0
VEZT	55591	broad.mit.edu	37	12	95694267	95694267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95694267C>T	ENST00000436874.1	+	12	2263	c.2158C>T	c.(2158-2160)Ccc>Tcc	p.P720S	VEZT_ENST00000261219.6_Missense_Mutation_p.P672S|VEZT_ENST00000356859.4_3'UTR	NM_017599.3	NP_060069.3	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane protein	720						acrosomal vesicle|adherens junction|integral to membrane|nucleus				endometrium(2)|kidney(3)|large_intestine(1)|lung(14)|ovary(2)|upper_aerodigestive_tract(1)	23						CTCATTACAGCCCTCCATTAA	0.507000													13	38					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67555523	67555523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:67555523G>A	ENST00000335894.4	+	3	304	c.238G>A	c.(238-240)Gag>Aag	p.E80K	IQCH_ENST00000546225.1_5'UTR|IQCH_ENST00000358767.3_5'UTR|IQCH_ENST00000512104.1_Missense_Mutation_p.E80K	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	80										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		TGTTAATGATGAGAGCTTATA	0.323000													19	77					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12123311	12123311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:12123311C>T	ENST00000379388.2	+	4	3615	c.3283C>T	c.(3283-3285)Ctt>Ttt	p.L1095F		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1095					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CCATATTCACCTTGTTGCCAG	0.463000													10	50					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156742096	156742096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156742096C>T	ENST00000347377.6	+	13	1781	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F	CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Silent_p.F124F|CYFIP2_ENST00000377576.3_Silent_p.F450F|CYFIP2_ENST00000318218.6_Silent_p.F450F|CYFIP2_ENST00000541131.1_Silent_p.F375F|CYFIP2_ENST00000522463.1_Silent_p.F254F|CYFIP2_ENST00000521420.1_Silent_p.F424F	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	450					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AATTTGCCTTCGTTGAGGTAG	0.527000													8	21					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70526220	70526220	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:70526220G>A	ENST00000327305.6	-	4	967	c.310C>T	c.(310-312)Cga>Tga	p.R104*	NETO1_ENST00000397929.1_Nonsense_Mutation_p.R103*|NETO1_ENST00000583169.1_Nonsense_Mutation_p.R104*|NETO1_ENST00000299430.2_Nonsense_Mutation_p.R103*|NETO1_ENST00000580049.1_5'UTR	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	104	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GGTCCATCTCGAACTTCAATA	0.378000													29	67					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802259	185802259	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185802259G>A	ENST00000302277.6	+	4	2730	c.2136G>A	c.(2134-2136)ggG>ggA	p.G712G		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	712						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TACATTCTGGGAAACATAATT	0.308000													26	71					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743045	26743045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26743045C>T	ENST00000396005.3	-	1	526	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	SLC5A12_ENST00000280467.6_Missense_Mutation_p.E73K	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	73					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						CGGTAGACTTCAGAAGGGGTC	0.512000													23	59					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57719770	57719770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57719770G>A	ENST00000333493.4	+	11	1633	c.1472G>A	c.(1471-1473)gGg>gAg	p.G491E	GPR97_ENST00000327655.6_Missense_Mutation_p.G281E|GPR97_ENST00000450388.3_Missense_Mutation_p.G371E|RP11-405F3.4_ENST00000563062.1_RNA	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	491					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GTGACATGGGGGTTGGCCATC	0.612000													21	56					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71850804	71850804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71850804G>A	ENST00000445078.2	+	5	858	c.787G>A	c.(787-789)Gag>Aag	p.E263K	FOLR3_ENST00000442948.2_Missense_Mutation_p.E222K|FOLR3_ENST00000456237.1_Missense_Mutation_p.E265K			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	221					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	CAACCCCAATGAGGAGGTGGC	0.572000													18	42					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27802836	27802836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27802836C>T	ENST00000408964.2	+	1	3448	c.3397C>T	c.(3397-3399)Cat>Tat	p.H1133Y		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1133										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					ACTTAATTGCCATCATAAATT	0.493000													69	151					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88476368	88476368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88476368C>T	ENST00000394480.1	-	16	2085	c.1764G>A	c.(1762-1764)gaG>gaA	p.E588E	NTRK3_ENST00000558676.1_Silent_p.E580E|NTRK3_ENST00000357724.2_Silent_p.E580E|NTRK3_ENST00000355254.2_Silent_p.E588E|NTRK3_ENST00000542733.2_Silent_p.E490E|NTRK3_ENST00000360948.2_Silent_p.E588E|NTRK3_ENST00000557856.1_Silent_p.E580E	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	588	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCAGCTCGGCCTCCCTCTGGA	0.562000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			11	84					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105161027	105161027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:105161027C>T	ENST00000436393.2	+	23	3580	c.3339C>T	c.(3337-3339)atC>atT	p.I1113I	RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000507740.1_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	541					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGTAGCTATCGTTGGTCTGT	0.483000										HNSCC(12;0.0054)			25	56					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325254	158325254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158325254C>T	ENST00000444681.2	+	2	516	c.223C>T	c.(223-225)Cgc>Tgc	p.R75C	CD1E_ENST00000368161.3_Missense_Mutation_p.R174C|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368167.3_Missense_Mutation_p.R174C|CD1E_ENST00000368163.3_Missense_Mutation_p.R174C|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368160.3_Missense_Mutation_p.R174C|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.R172C|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368165.3_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	174					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					AGTGCTCAATCGCTACCTAGA	0.507000													31	67					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	88123744	88123744	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88123744G>A	ENST00000327946.7	-	2	274	c.189C>T	c.(187-189)tcC>tcT	p.S63S		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	63						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TGACCTTGATGGAGTAGGTGA	0.612000										Multiple Myeloma(13;0.14)			26	65					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870966	13870966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13870966C>T	ENST00000265104.4	-	24	3848	c.3744G>A	c.(3742-3744)aaG>aaA	p.K1248K	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1248	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CATCTAGGTCCTTAATTGGAC	0.373000									Kartagener syndrome				21	73					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142238075	142238075	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:142238075G>A	ENST00000389484.3	-	3	1204	c.233C>T	c.(232-234)cCc>cTc	p.P78L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	78	LDL-receptor class A 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTGATTCAAGGGGCACTTGAT	0.408000										TSP Lung(27;0.18)			14	107					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230572	21230572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21230572C>T	ENST00000233242.1	-	26	9295	c.9168G>A	c.(9166-9168)ttG>ttA	p.L3056L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3056					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACGAACTTTCAAATTCCCTT	0.393000													24	70					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12711243	12711243	+	Silent	SNP	C	C	T	rs140616597		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12711243C>T	ENST00000376221.1	+	2	270	c.270C>T	c.(268-270)acC>acT	p.T90T		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	90						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TTGTGGTGACCGACCTGCGTT	0.502000													44	107					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180053204	180053204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180053204C>T	ENST00000261937.6	-	9	1243	c.1165G>A	c.(1165-1167)Gtg>Atg	p.V389M	FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Missense_Mutation_p.V389M|FLT4_ENST00000502649.1_Missense_Mutation_p.V389M	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	389	Ig-like C2-type 4.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GCCTCTGTCACCTCCTTGAGC	0.627000													37	80					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104878	183104878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:183104878C>T	ENST00000435564.1	-	3	557	c.357G>A	c.(355-357)cgG>cgA	p.R119R	PDE1A_ENST00000346717.4_Silent_p.R85R|PDE1A_ENST00000358139.2_Silent_p.R119R|PDE1A_ENST00000331935.6_Silent_p.R119R|PDE1A_ENST00000456212.1_Silent_p.R119R|PDE1A_ENST00000536095.1_Silent_p.R15R|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Silent_p.R119R|PDE1A_ENST00000409365.1_Silent_p.R103R|PDE1A_ENST00000351439.5_Silent_p.R103R	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	119					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			GCACAATGCTCCGAAATTTTG	0.418000													31	113					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232651033	232651033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:232651033G>A	ENST00000366630.1	-	2	411	c.53C>T	c.(52-54)tCt>tTt	p.S18F	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.S18F			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	18					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GAACTTTGAAGAGGCTCTGCC	0.453000													8	66					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151128379	151128379	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151128379G>A	ENST00000370325.1	-	6	769	c.716C>T	c.(715-717)tCc>tTc	p.S239F	GABRE_ENST00000370328.3_Missense_Mutation_p.S239F|GABRE_ENST00000393914.3_Missense_Mutation_p.S46F			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	239					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GAGCTTCCAGGAGTTCTTCTC	0.433000													32	39					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190250839	190250839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190250839C>T	ENST00000367462.3	-	3	509	c.278G>A	c.(277-279)aGa>aAa	p.R93K	FAM5C_ENST00000484105.1_Intron|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000534846.1_Intron	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		93						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GAAATTTCTTCTCTCAACTGC	0.398000													20	91					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925570	54925570	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54925570C>T	ENST00000293373.6	+	25	2821	c.2742C>T	c.(2740-2742)atC>atT	p.I914I	NCKAP1L_ENST00000545638.2_Silent_p.I864I	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	914					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TTGGGGTTATCCTCAGTTTCA	0.493000													20	48					0	0	1	0	0
AGK	55750	broad.mit.edu	37	7	141336797	141336797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141336797C>T	ENST00000355413.4	+	11	966	c.706C>T	c.(706-708)Cac>Tac	p.H236Y	AGK_ENST00000473247.1_Missense_Mutation_p.H208Y|AGK_ENST00000535825.1_Missense_Mutation_p.H233Y	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase	236					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					CAAAGCAGCCCACTTTTTCAG	0.313000													10	50					0	0	1	0	0
TRAV12-2	28673	broad.mit.edu	37	14	22356412	22356412	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22356412G>A	ENST00000390437.2	+	0	175																											CCAACAGAAGGAGGTGGAGCA	0.498000													18	58					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100334587	100334587	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100334587C>T	ENST00000542585.1	+	0	557				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCTGCTGCTGCTCTCGGGTGA	0.652000													4	10					0	0	1	0	0
CETN1	1068	broad.mit.edu	37	18	580894	580894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:580894C>T	ENST00000327228.3	+	1	528	c.486C>T	c.(484-486)ttC>ttT	p.F162F		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	162	EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						AGGAGGAGTTCCTTCGGATCA	0.532000													20	45					0	0	1	0	0
PPP1R17	10842	broad.mit.edu	37	7	31735138	31735138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31735138G>A	ENST00000342032.3	+	3	766	c.138G>A	c.(136-138)aaG>aaA	p.K46K	PPP1R17_ENST00000409146.3_Intron	NM_006658.4	NP_006649.2	O96001	GSUB_HUMAN	protein phosphatase 1, regulatory subunit 17	46					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction											AGCCTAGAAAGGGAAAAAATG	0.388000													31	98					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179510666	179510666	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179510666C>T	ENST00000589042.1	-	217	40613	c.40389G>A	c.(40387-40389)gaG>gaA	p.E13463E	TTN_ENST00000342992.6_Silent_p.E10895E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.E11822E|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11822	Ig-like 90.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAATATTTTCTCCTTCACAT	0.408000													3	9					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128335798	128335798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128335798G>A	ENST00000389524.4	+	9	993	c.940G>A	c.(940-942)Gag>Aag	p.E314K	MYO7B_ENST00000428314.1_Missense_Mutation_p.E314K|MYO7B_ENST00000409816.2_Missense_Mutation_p.E314K			Q6PIF6	MYO7B_HUMAN	myosin VIIB	314	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTCCGACTCCGAGAGCTGGGA	0.607000													10	32					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200943915	200943915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200943915C>T	ENST00000332129.2	-	33	5018	c.4702G>A	c.(4702-4704)Ggt>Agt	p.G1568S	KIF21B_ENST00000461742.2_Missense_Mutation_p.G1581S|KIF21B_ENST00000360529.5_Missense_Mutation_p.G1568S|KIF21B_ENST00000422435.2_Missense_Mutation_p.G1581S	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1581					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TTGATCTCACCGATGGGTGTG	0.612000													42	82					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5731072	5731072	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:5731072C>T	ENST00000382674.2	+	3	523	c.339C>T	c.(337-339)ttC>ttT	p.F113F	EVC_ENST00000264956.6_Silent_p.F113F|EVC_ENST00000509451.1_Silent_p.F113F			P57679	EVC_HUMAN	Ellis van Creveld syndrome	113					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				TCACAGCATTCGCCCTGAAGG	0.483000													7	85					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14823176	14823176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14823176C>T	ENST00000380881.4	-	14	3137	c.2322G>A	c.(2320-2322)gtG>gtA	p.V774V	FREM1_ENST00000422223.2_Silent_p.V773V|FREM1_ENST00000380880.3_Silent_p.V773V			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	773					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CTTGATTGTCCACTGGGAGGA	0.413000													7	56					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27802502	27802502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27802502G>A	ENST00000408964.2	+	1	3114	c.3063G>A	c.(3061-3063)ggG>ggA	p.G1021G		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1021										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CATGTGCAGGGGGCCAGCTTC	0.438000													16	92					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19822367	19822367	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19822367G>A	ENST00000344099.3	-	4	1861	c.1723C>T	c.(1723-1725)Cga>Tga	p.R575*		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R575*(1)		breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				TCATGCATTCGAAATTTACTG	0.403000													24	64					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104071293	104071293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104071293G>A	ENST00000388887.2	+	25	2913	c.2709G>A	c.(2707-2709)ggG>ggA	p.G903G		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	903	EGF-like 8.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTTGGACAGGGAATGGGAGAG	0.572000													30	103					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018324	1018324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1018324C>T	ENST00000398484.2	+	7	1524	c.944C>T	c.(943-945)cCc>cTc	p.P315L	FGFRL1_ENST00000510644.1_Missense_Mutation_p.P315L|FGFRL1_ENST00000264748.6_Missense_Mutation_p.P315L|FGFRL1_ENST00000504138.1_Missense_Mutation_p.P315L			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	315	Ig-like C2-type 3.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TGGTCGCGGCCCGACGGCTCC	0.647000													18	74					0	0	1	0	0
TEX33	339669	broad.mit.edu	37	22	37397962	37397962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37397962C>T	ENST00000405091.2	-	4	656	c.405G>A	c.(403-405)acG>acA	p.T135T	TEX33_ENST00000381821.1_Silent_p.T135T|TEX33_ENST00000402860.3_Silent_p.T50T			O43247	EAN57_HUMAN	testis expressed 33	135																	CCTTCTGGTTCGTGGGCGTGC	0.622000													4	25					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94502778	94502778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94502778G>A	ENST00000370225.3	-	25	3822	c.3736C>T	c.(3736-3738)Ctt>Ttt	p.L1246F		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1246					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTCTGAAAAGGCTGGCATAT	0.483000													16	110					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15376433	15376433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15376433G>A	ENST00000263377.2	-	5	802	c.581C>T	c.(580-582)tCc>tTc	p.S194F	BRD4_ENST00000360016.5_Missense_Mutation_p.S194F|BRD4_ENST00000371835.4_Missense_Mutation_p.S194F	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	194					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TGGTACCGTGGAAACGCCAGG	0.567000			T	C15orf55	lethal midline carcinoma of young people								69	178					0	0	1	0	0
CALHM1	255022	broad.mit.edu	37	10	105215432	105215432	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105215432T>A	ENST00000329905.5	-	2	764	c.628A>T	c.(628-630)Acg>Tcg	p.T210S	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	210						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						GCGGCCTGCGTGAAGCAGGGC	0.612000													9	62					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7262416	7262416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7262416G>A	ENST00000361972.4	-	11	1377	c.1287C>T	c.(1285-1287)tcC>tcT	p.S429S	SFMBT2_ENST00000397167.1_Silent_p.S429S	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	429					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						CACTCACAACGGAGGCCACAC	0.517000													101	216					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43858479	43858479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43858479G>A	ENST00000389420.3	-	10	1423	c.1424C>T	c.(1423-1425)cCt>cTt	p.P475L	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.P475L	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	475	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAGTTCTGAAGGCAGATTATA	0.383000													11	70					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48371472	48371472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48371472G>A	ENST00000395702.2	+	2	1167	c.940G>A	c.(940-942)Gaa>Aaa	p.E314K	ZNF488_ENST00000586537.1_Missense_Mutation_p.E207K|ZNF488_ENST00000494156.1_3'UTR			Q96MN9	ZN488_HUMAN	zinc finger protein 488	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						GAAGCGGAGAGAAGAGGCCCT	0.597000													38	91					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62859106	62859106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62859106G>A	ENST00000584306.1	-	10	3614	c.3084C>T	c.(3082-3084)ctC>ctT	p.L1028L	LRRC37A3_ENST00000400877.3_Silent_p.L66L|LRRC37A3_ENST00000334962.5_Silent_p.L5L|LRRC37A3_ENST00000319651.5_Silent_p.L1028L|LRRC37A3_ENST00000339474.5_Silent_p.L146L	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1028						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TAAATTGGCAGAGGCAGCAGG	0.453000													96	217					0	0	1	0	0
CTAGE6	340307	broad.mit.edu	37	7	143453470	143453470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143453470C>T	ENST00000470691.2	-	1	1319	c.1282G>A	c.(1282-1284)Gaa>Aaa	p.E428K		NM_178561.4	NP_848656.2			CTAGE family, member 6													Melanoma(164;0.0903)					TCCAGCTGTTCAGTGGCACGG	0.383000													41	325					0	0	1	0	0
CCRL2	9034	broad.mit.edu	37	3	46450311	46450311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46450311C>T	ENST00000399036.3	+	2	1093	c.741C>T	c.(739-741)ttC>ttT	p.F247F	ACKR5_ENST00000400880.3_Silent_p.F247F|ACKR5_ENST00000357392.4_Silent_p.F259F|ACKR5_ENST00000400882.2_Silent_p.F247F	NM_003965.4	NP_003956.2																					TGGTAGTCTTCCTTCTGATGT	0.403000													144	384					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	87917351	87917351	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87917351G>A	ENST00000518476.1	+	3	252	c.201G>A	c.(199-201)atG>atA	p.M67I		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	67										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						ATACATTTATGAAGCAATATC	0.358000													8	24					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614802	247614802	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247614802G>A	ENST00000318749.6	-	1	506	c.483C>T	c.(481-483)ttC>ttT	p.F161F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCACCTGCACGAAGGAGTTGC	0.602000													9	40					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55874926	55874926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55874926G>A	ENST00000388975.3	-	8	959	c.843C>T	c.(841-843)ttC>ttT	p.F281F		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	281					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GGAGCTTAACGAAGTCACAGT	0.328000													26	56					0	0	1	0	0
TMEM9	252839	broad.mit.edu	37	1	201115880	201115880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201115880G>A	ENST00000367330.1	-	3	771	c.255C>T	c.(253-255)acC>acT	p.T85T	TMEM9_ENST00000367333.1_Silent_p.T88T|TMEM9_ENST00000367334.5_Silent_p.T85T|TMEM9_ENST00000367329.1_Silent_p.T85T|TMEM9_ENST00000367332.1_Silent_p.T88T			Q9P0T7	TMEM9_HUMAN	transmembrane protein 9	85					transport	integral to membrane|late endosome membrane|lysosomal membrane				liver(1)|lung(1)|stomach(1)	3		Breast(1374;0.000301)				TGATGGTGGTGGTGCTGCGCT	0.592000													19	99					0	0	1	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273370	26273370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26273370C>T	ENST00000377733.2	+	1	227	c.167C>T	c.(166-168)tCg>tTg	p.S56L		NM_003525.2	NP_003516.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	56					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			central_nervous_system(1)|cervix(2)|endometrium(3)|large_intestine(1)|lung(8)|urinary_tract(1)	16						ACCGGCATCTCGTCCAAGGCT	0.567000													104	261					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10261405	10261405	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10261405C>T	ENST00000256458.4	+	8	1035	c.945C>T	c.(943-945)atC>atT	p.I315I		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	315	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						GTGTCAGCATCTGCTCAGGGC	0.567000													17	30					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29821054	29821054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:29821054C>T	ENST00000375398.2	-	11	2335	c.1886G>A	c.(1885-1887)gGt>gAt	p.G629D	SVIL_ENST00000355867.4_Missense_Mutation_p.G629D|SVIL_ENST00000375400.3_Intron			O95425	SVIL_HUMAN	supervillin	629					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CCGTTCCACACCGGTGGGCAA	0.488000													33	79					0	0	1	0	0
C10orf113	387638	broad.mit.edu	37	10	21414770	21414770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21414770C>T	ENST00000534331.1	-	2	500	c.450G>A	c.(448-450)ctG>ctA	p.L150L	C10orf113_ENST00000529198.1_3'UTR|NEBL_ENST00000417816.2_Intron|C10orf113_ENST00000377118.4_Silent_p.L140L	NM_001010896.2	NP_001010896.2	Q5VZT2	CJ113_HUMAN	chromosome 10 open reading frame 113	150										endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|pancreas(1)	7						AAGTCATTTTCAGCACCTTCT	0.393000													51	163					0	0	1	0	0
RBM6	10180	broad.mit.edu	37	3	50099460	50099460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50099460C>T	ENST00000443081.1	+	15	3028	c.2109C>T	c.(2107-2109)ccC>ccT	p.P703P	RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000442092.1_Silent_p.P313P|RBM6_ENST00000422955.1_Silent_p.P313P|RBM6_ENST00000539992.1_Silent_p.P177P|RBM6_ENST00000266022.4_Silent_p.P835P			P78332	RBM6_HUMAN	RNA binding motif protein 6	835					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AAAAAAAACCCACCAGTCAAG	0.418000													19	63					0	0	1	0	0
MARK4	57787	broad.mit.edu	37	19	45805827	45805827	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45805827C>G	ENST00000262891.4	+	17	2449	c.2118C>G	c.(2116-2118)ccC>ccG	p.P706P	MARK4_ENST00000300843.4_3'UTR	NM_001199867.1	NP_001186796.1	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	706	KA1.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CGGGCGGGCCCGAGCCCCTGT	0.741000													5	7					0	0	1	0	0
VNN3	55350	broad.mit.edu	37	6	133047941	133047941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:133047941G>A	ENST00000367927.5	-	4	820	c.748C>T	c.(748-750)Cct>Tct	p.P250S	VNN3_ENST00000427187.2_Intron|VNN3_ENST00000417437.2_Intron|VNN3_ENST00000450865.2_Silent_p.S128S|VNN3_ENST00000207771.3_Missense_Mutation_p.P249L|VNN3_ENST00000519686.2_3'UTR|VNN3_ENST00000425515.2_3'UTR|VNN3_ENST00000414302.2_3'UTR|VNN3_ENST00000509351.1_Intron|VNN3_ENST00000392393.3_3'UTR|VNN3_ENST00000423615.2_Intron|VNN3_ENST00000275223.3_Intron					vanin 3											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	8	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00242)|GBM - Glioblastoma multiforme(226;0.0168)		TGAATGGAAGGGAACAGCCGA	0.542000													31	50					0	0	1	0	0
SPRED1	161742	broad.mit.edu	37	15	38591722	38591722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:38591722C>T	ENST00000299084.4	+	2	1041	c.181C>T	c.(181-183)Cgt>Tgt	p.R61C	SPRED1_ENST00000561205.1_3'UTR	NM_152594.2	NP_689807.1	Q7Z699	SPRE1_HUMAN	sprouty-related, EVH1 domain containing 1	61	WH1.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			kidney(6)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CTTTTTTATCCGTGGAGAGCG	0.383000									Legius syndrome				25	65					0	0	1	0	0
TCP10L	140290	broad.mit.edu	37	21	33956525	33956525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:33956525C>T	ENST00000300258.3	-	2	203	c.90G>A	c.(88-90)aaG>aaA	p.K30K		NM_144659.5	NP_653260.1			t-complex 10-like											breast(1)|central_nervous_system(1)|liver(1)|skin(1)	4						CCACAGCTGTCTTCTCCATGA	0.632000													29	65					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158291210	158291210	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158291210C>T	ENST00000264192.3	-	2	345	c.224_splice	c.e2+1	p.R75_splice	CYTIP_ENST00000540637.1_5'UTR|CYTIP_ENST00000497432.1_5'UTR	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	75					regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						ATCTCTTTACCTTTGAGACCA	0.378000													8	28					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188077	7188077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7188077C>T	ENST00000542285.1	-	11	1870	c.1721G>A	c.(1720-1722)gGa>gAa	p.G574E				P00736	C1R_HUMAN	complement component 1, r subcomponent	626	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCTATTCTTTCCCCGGAGCCA	0.542000													12	26					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63726872	63726872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:63726872G>A	ENST00000421025.1	+	5	1130	c.861G>A	c.(859-861)aaG>aaA	p.K287K	ZNF679_ENST00000255746.4_Silent_p.K287K	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						CTAACCACAAGAGAATTCATA	0.428000													24	52					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146805352	146805352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:146805352G>A	ENST00000361727.3	+	5	1180	c.664G>A	c.(664-666)Gaa>Aaa	p.E222K		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	222	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.E222Q(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTCTGAAAGTGAAGGAGTAAT	0.398000										HNSCC(39;0.1)			23	34					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200880878	200880878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200880878C>T	ENST00000367342.4	+	9	1712	c.1512C>T	c.(1510-1512)gtC>gtT	p.V504V	C1orf106_ENST00000413687.2_Silent_p.V419V	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	504										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						GAGAGCTGGTCGCCCACCACC	0.701000													41	45					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48607739	48607739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48607739G>A	ENST00000328333.8	-	97	7516	c.7409C>T	c.(7408-7410)cCc>cTc	p.P2470L	COL7A1_ENST00000454817.1_Missense_Mutation_p.P2438L	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2470	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCGCCTCGGGGCCCAGGCAG	0.622000													23	72					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31318615	31318615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31318615C>T	ENST00000269197.5	+	11	1247	c.1247C>T	c.(1246-1248)cCt>cTt	p.P416L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TCTCCAGAGCCTGGTTTCTGT	0.453000													17	38					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919144	12919144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12919144C>T	ENST00000240189.2	+	2	367	c.280C>T	c.(280-282)Cgc>Tgc	p.R94C		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	94										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACAGAAGGATCGCCCCAGGTG	0.552000													95	308					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432527	30432527	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30432527G>A	ENST00000375978.3	-	1	893	c.819C>T	c.(817-819)gcC>gcT	p.A273A		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	273					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CAGGGGAGGGGGCTGCTGAGG	0.652000													9	16					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190194	209190194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:209190194C>T	ENST00000264380.4	+	20	2817	c.2659C>T	c.(2659-2661)Cct>Tct	p.P887S		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	887					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						AATGCAAAACCCTTCATTCCA	0.468000													34	90					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1278759	1278759	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1278759G>A	ENST00000310581.5	-	6	2340	c.2283C>T	c.(2281-2283)agC>agT	p.S761S	TERT_ENST00000296820.5_Silent_p.S761S|TERT_ENST00000508104.2_Silent_p.S761S|TERT_ENST00000334602.6_Silent_p.S761S	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	761	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACCTTACGTGGCTCTTGAAGG	0.552000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				152	308					0	0	1	0	0
C16orf46	123775	broad.mit.edu	37	16	81095106	81095106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81095106G>A	ENST00000378611.4	-	3	963	c.848C>T	c.(847-849)tCc>tTc	p.S283F	C16orf46_ENST00000299578.5_Missense_Mutation_p.S283F|RP11-303E16.8_ENST00000564536.1_RNA	NM_001100873.1	NP_001094343.1	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46	283										NS(1)|endometrium(2)|large_intestine(3)|lung(9)|prostate(1)|stomach(1)|urinary_tract(1)	18						GGCCGCTGGGGAAGGGGAGGA	0.577000													44	186					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148258	34148258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34148258G>A	ENST00000346193.3	-	1	2189	c.2138C>T	c.(2137-2139)cCt>cTt	p.P713L		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	713										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GTCAATCAAAGGTTCATCACT	0.423000													53	37					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55578978	55578978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55578978C>T	ENST00000333973.2	+	1	125	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TGGCTGAGTTCATTCTCCTTG	0.423000													71	196					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673597	186673597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:186673597G>A	ENST00000343098.5	+	17	19831	c.19831G>A	c.(19831-19833)Gtt>Att	p.V6611I	FSIP2_ENST00000424728.1_Missense_Mutation_p.V6522I	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AATTAAAATAGTTCCACATGT	0.303000													10	67					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107677897	107677897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107677897C>T	ENST00000388781.3	-	30	4698	c.4615G>A	c.(4615-4617)Gaa>Aaa	p.E1539K	LAMB4_ENST00000483484.1_5'UTR|LAMB4_ENST00000205386.4_Missense_Mutation_p.E1539K|LAMB4_ENST00000388780.3_Missense_Mutation_p.E1539K	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1539	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						AACCTGTTTTCATCTGTCCTG	0.388000													77	252					0	0	1	0	0
VAMP7	6845	broad.mit.edu	37	X	155127867	155127867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:155127867C>T	ENST00000286448.6	+	4	461	c.296C>T	c.(295-297)cCa>cTa	p.P99L	VAMP7_ENST00000460621.1_Missense_Mutation_p.P58L|VAMP7_ENST00000479687.1_3'UTR|VAMP7_ENST00000262640.6_Missense_Mutation_p.P99L	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	99	Longin.				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACAGCACTTCCATATGCCATG	0.393000													58	116					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48624743	48624743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48624743G>A	ENST00000328333.8	-	23	3126	c.3019C>T	c.(3019-3021)Cca>Tca	p.P1007S	COL7A1_ENST00000454817.1_Missense_Mutation_p.P1007S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1007	Fibronectin type-III 9.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GAGATCCCTGGAAGTGTCTGC	0.597000													5	6					0	0	1	0	0
PTGFR	5737	broad.mit.edu	37	1	78958579	78958579	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:78958579C>T	ENST00000370756.3	+	2	388	c.151C>T	c.(151-153)Ctc>Ttc	p.L51F	PTGFR_ENST00000370757.3_Missense_Mutation_p.L51F|PTGFR_ENST00000370758.1_Missense_Mutation_p.L51F	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	51					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CATCGCCATTCTCATGAAGGC	0.443000													58	108					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185798354	185798354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185798354G>A	ENST00000302277.6	+	3	874	c.280G>A	c.(280-282)Gaa>Aaa	p.E94K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	94						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GAAACAAAGGGAATTTGCTCG	0.358000													24	66					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31697609	31697609	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:31697609C>T	ENST00000357033.4	-	53	7961	c.7755G>A	c.(7753-7755)tgG>tgA	p.W2585*	DMD_ENST00000474231.1_Nonsense_Mutation_p.W125*|DMD_ENST00000359836.1_Nonsense_Mutation_p.W125*|DMD_ENST00000378677.2_Nonsense_Mutation_p.W2581*|DMD_ENST00000378707.3_Nonsense_Mutation_p.W125*|DMD_ENST00000343523.2_Nonsense_Mutation_p.W125*|DMD_ENST00000541735.1_Nonsense_Mutation_p.W125*	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2585					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TAGCTTCCAGCCATTGTGTTG	0.443000													20	16					0	0	1	0	0
CRTC1	23373	broad.mit.edu	37	19	18856637	18856637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18856637C>T	ENST00000338797.6	+	4	321	c.296C>T	c.(295-297)cCc>cTc	p.P99L	CRTC1_ENST00000321949.8_Missense_Mutation_p.P83L|CRTC1_ENST00000601916.1_Missense_Mutation_p.P8L|CRTC1_ENST00000594658.1_Missense_Mutation_p.P42L	NM_001098482.1	NP_001091952.1	Q6UUV9	CRTC1_HUMAN	CREB regulated transcription coactivator 1	83					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	19						CCCCAGACCCCCTTCCAATCC	0.662000													34	149					0	0	1	0	0
SF3B3	23450	broad.mit.edu	37	16	70605012	70605012	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70605012C>T	ENST00000302516.5	+	25	3634	c.3423C>T	c.(3421-3423)ttC>ttT	p.F1141F		NM_012426.4	NP_036558.3	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3, 130kDa	1141					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(2)|endometrium(8)|kidney(2)|large_intestine(8)|liver(3)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	53		Ovarian(137;0.0694)				ATGACTTCTTCCAGCATGTGG	0.498000													51	136					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2622120	2622120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2622120G>A	ENST00000399655.1	+	9	1625	c.1360G>A	c.(1360-1362)Gaa>Aaa	p.E454K	CACNA1C_ENST00000399637.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000480911.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000335762.5_Missense_Mutation_p.E454K|CACNA1C_ENST00000399603.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399649.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000399595.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399606.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399601.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399617.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000344100.3_Missense_Mutation_p.E454K|CACNA1C_ENST00000399621.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399629.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000327702.7_Missense_Mutation_p.E454K|CACNA1C_ENST00000406454.3_Missense_Mutation_p.E454K|CACNA1C_ENST00000402845.3_Missense_Mutation_p.E454K|CACNA1C_ENST00000399597.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000347598.4_Missense_Mutation_p.E454K|CACNA1C_ENST00000399641.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399638.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399644.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399591.1_Missense_Mutation_p.E454K|CACNA1C_ENST00000399634.1_Missense_Mutation_p.E454K	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	454					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GAATGAGGACGAAGGCATGGA	0.552000													5	7					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110819735	110819735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110819735G>A	ENST00000282356.4	+	11	1391	c.993G>A	c.(991-993)aaG>aaA	p.K331K	CAMK4_ENST00000512890.1_3'UTR|CAMK4_ENST00000512453.1_Silent_p.K331K	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	331	Calmodulin-binding (Potential).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		CAGCGGTGAAGGCTGTGGTGG	0.557000													15	35					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141128297	141128297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141128297C>T	ENST00000389484.3	-	71	11961	c.10990G>A	c.(10990-10992)Gaa>Aaa	p.E3664K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3664	LDL-receptor class A 29.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGTTCTCTTCATCACTGCCA	0.393000										TSP Lung(27;0.18)			111	229					0	0	1	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21929377	21929377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21929377C>T	ENST00000542643.2	-	21	1838	c.1536G>A	c.(1534-1536)acG>acA	p.T512T	RAP1GAP_ENST00000374765.4_Silent_p.T486T|RAP1GAP_ENST00000374761.2_Silent_p.T517T|RAP1GAP_ENST00000374763.2_Silent_p.T571T|RAP1GAP_ENST00000290101.4_Silent_p.T550T	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	487					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		ACTTCTTCCTCGTGGGGCTCT	0.647000													4	47					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125281491	125281491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125281491G>A	ENST00000340750.1	+	1	72	c.72G>A	c.(70-72)caG>caA	p.Q24Q		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Q24H(1)		large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						CAGAGCAGCAGGCTGTGTTCT	0.557000													28	128					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	19062482	19062482	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19062482C>T	ENST00000375375.3	+	8	2110	c.1512C>T	c.(1510-1512)tcC>tcT	p.S504S	PAX7_ENST00000420770.2_Intron|PAX7_ENST00000400661.3_Silent_p.S502S	NM_002584.2|NM_013945.2	NP_002575.1|NP_039236.1	P23759	PAX7_HUMAN	paired box 7	504					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		ggggaatgtccatttcacaga	0.542000			T	FOXO1A	alveolar rhabdomyosarcoma								11	12					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123901226	123901226	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123901226G>A	ENST00000431524.1	+	1	930	c.897G>A	c.(895-897)ttG>ttA	p.L299L		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AAGCTCTGTTGAAGCTGAAAG	0.458000													30	81					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149882467	149882467	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149882467C>T	ENST00000369146.3	-	4	1356	c.866G>A	c.(865-867)cGa>cAa	p.R289Q	SV2A_ENST00000369145.1_Missense_Mutation_p.R289Q	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	289					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	ATGCTCCCCTCGTTTCTCCTG	0.527000													8	44					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118357408	118357408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118357408G>A	ENST00000528052.1	+	7	714	c.643G>A	c.(643-645)Gac>Aac	p.D215N	PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.D215N|PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.D215N			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	215					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		CTCTGATGCTGACTTTGTTGA	0.478000													32	68					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166976277	166976277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:166976277G>A	ENST00000061240.2	+	13	2221	c.1574G>A	c.(1573-1575)gGa>gAa	p.G525E	TLL1_ENST00000507499.1_Missense_Mutation_p.G548E	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	525	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GTTAGAGATGGAACCAGTGAA	0.338000													30	83					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74695422	74695422	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74695422G>A	ENST00000373032.3	-	4	633	c.541C>T	c.(541-543)Cag>Tag	p.Q181*		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	181					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					GCTGCCCGCTGACTATTCATA	0.507000													34	70					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	628806	628806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:628806C>T	ENST00000321878.5	+	6	1250	c.1091C>T	c.(1090-1092)cCc>cTc	p.P364L	PIGQ_ENST00000409527.2_Missense_Mutation_p.P364L|PIGQ_ENST00000544860.1_3'UTR|PIGQ_ENST00000026218.5_Missense_Mutation_p.P364L	NM_004204.3	NP_004195.2	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	364	Leu-rich.				C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				CTCATGTCCCCCTTCGTGGAG	0.657000													44	66					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241727533	241727533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241727533C>T	ENST00000498729.2	-	4	544	c.298G>A	c.(298-300)Ggt>Agt	p.G100S	KIF1A_ENST00000320389.7_Missense_Mutation_p.G100S	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	100	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TTGCCGGCACCCGTCTGCCCA	0.642000													4	10					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678521	88678521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88678521C>T	ENST00000394480.1	-	10	1336	c.1015G>A	c.(1015-1017)Ggg>Agg	p.G339R	NTRK3_ENST00000558676.1_Missense_Mutation_p.G339R|NTRK3_ENST00000357724.2_Missense_Mutation_p.G339R|NTRK3_ENST00000317501.3_Missense_Mutation_p.G339R|NTRK3_ENST00000355254.2_Missense_Mutation_p.G339R|NTRK3_ENST00000542733.2_Missense_Mutation_p.G241R|NTRK3_ENST00000540489.2_Missense_Mutation_p.G339R|NTRK3_ENST00000360948.2_Missense_Mutation_p.G339R|NTRK3_ENST00000557856.1_Missense_Mutation_p.G339R	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	339	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGAGGCTGCCCATTGTGCAGC	0.592000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			16	107					0	0	1	0	0
LARP4B	23185	broad.mit.edu	37	10	861007	861007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:861007G>A	ENST00000316157.3	-	15	1739	c.1699C>T	c.(1699-1701)Ctc>Ttc	p.L567F	LARP4B_ENST00000469487.1_5'UTR	NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	567							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						TCTGCACTGAGGGTCTGAAAC	0.592000													17	39					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594815	64594815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64594815G>A	ENST00000342711.5	-	33	4205	c.4206C>T	c.(4204-4206)ttC>ttT	p.F1402F		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1402					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						TCTTGGTGCGGAACAGCTGGC	0.652000													27	121					0	0	1	0	0
ZFP1	162239	broad.mit.edu	37	16	75203605	75203605	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:75203605C>T	ENST00000393430.2	+	4	721	c.597C>T	c.(595-597)ctC>ctT	p.L199L	ZFP1_ENST00000568079.1_3'UTR|ZFP1_ENST00000570010.1_Silent_p.L199L|ZFP1_ENST00000464850.1_3'UTR|ZFP1_ENST00000332307.4_Silent_p.L166L			Q6P2D0	ZFP1_HUMAN	ZFP1 zinc finger protein	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	12						AGTCACTCCTCATTAGTCATA	0.358000													13	44					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19451867	19451867	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19451867C>T	ENST00000396229.2	+	3	1256	c.507C>T	c.(505-507)aaC>aaT	p.N169N	TMC5_ENST00000542583.2_Silent_p.N169N|TMC5_ENST00000541464.1_Silent_p.N169N|TMC5_ENST00000381414.4_Silent_p.N169N	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	169						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CTCAGAGCAACTCTGATCATC	0.478000													43	144					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78474955	78474955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78474955C>T	ENST00000258873.4	-	7	952	c.747G>A	c.(745-747)atG>atA	p.M249I	ACSBG1_ENST00000560817.1_Missense_Mutation_p.M7I|ACSBG1_ENST00000541759.1_Missense_Mutation_p.M7I	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	249					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						TGAATTCCTCCATCTGTAGCC	0.607000													23	86					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39884771	39884771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39884771G>A	ENST00000260356.5	+	17	2700	c.2535G>A	c.(2533-2535)ctG>ctA	p.L845L		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	845					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TCTTTCAGCTGGACTCTGACT	0.433000													5	13					0	0	1	0	0
TOP2B	7155	broad.mit.edu	37	3	25665215	25665215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:25665215G>A	ENST00000435706.2	-	21	2704	c.2503C>T	c.(2503-2505)Cct>Tct	p.P835S	TOP2B_ENST00000264331.4_Missense_Mutation_p.P840S			Q02880	TOP2B_HUMAN	topoisomerase (DNA) II beta 180kDa	840					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|skin(2)|stomach(1)	36						TCCACAGCAGGAAAAAGTAGC	0.333000													9	25					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180338372	180338372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180338372G>A	ENST00000231229.4	+	3	665	c.431G>A	c.(430-432)gGa>gAa	p.G144E	BTNL8_ENST00000533815.2_5'UTR|BTNL8_ENST00000400707.3_Missense_Mutation_p.G19E|BTNL8_ENST00000511704.1_Missense_Mutation_p.G28E|BTNL8_ENST00000340184.4_Missense_Mutation_p.G144E|BTNL8_ENST00000508408.1_Missense_Mutation_p.G144E|BTNL8_ENST00000505126.1_5'UTR	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	144	Ig-like V-type 2.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCATCACGGGATATGTTGAT	0.522000													38	399					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64159417	64159417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:64159417G>A	ENST00000395254.3	+	5	1373	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K	ZNF365_ENST00000410046.3_Intron|ZNF365_ENST00000395255.3_Intron|ZNF365_ENST00000466727.1_3'UTR	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					GGCCATTCACGAACAGGCTGA	0.547000													22	180					0	0	1	0	0
SMCP	4184	broad.mit.edu	37	1	152856947	152856947	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152856947C>T	ENST00000368765.3	+	2	199	c.49C>T	c.(49-51)Caa>Taa	p.Q17*		NM_030663.2	NP_109588.2	P49901	MCSP_HUMAN	sperm mitochondria-associated cysteine-rich protein	17	7 X 7 (OR 8) AA approximate repeats.				penetration of zona pellucida|sperm motility	mitochondrial membrane				breast(1)|cervix(1)|endometrium(1)|lung(4)|urinary_tract(1)	8	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAAAGGCAATCAATGCTGCCC	0.458000													16	95					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43322721	43322721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43322721G>A	ENST00000331495.3	+	22	3166	c.2830G>A	c.(2830-2832)Gag>Aag	p.E944K	FMNL1_ENST00000587489.1_Missense_Mutation_p.E522K|CTD-2020K17.4_ENST00000420431.2_RNA|FMNL1_ENST00000328118.3_Missense_Mutation_p.E944K	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	944	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						GGTGCTCAAGGAGTTCCTGAG	0.632000													34	39					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112524985	112524985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112524985C>T	ENST00000369697.1	-	1	433	c.364G>A	c.(364-366)Ggc>Agc	p.G122S	KCND3_ENST00000315987.2_Missense_Mutation_p.G122S|KCND3_ENST00000302127.4_Missense_Mutation_p.G122S			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	122						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGGAGGATGCCGTAGAAGGCC	0.617000													10	71					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	136111119	136111119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136111119G>A	ENST00000401392.1	-	4	472	c.260C>T	c.(259-261)cCt>cTt	p.P87L	ZRANB3_ENST00000536680.1_Missense_Mutation_p.P87L|ZRANB3_ENST00000264159.6_Missense_Mutation_p.P87L			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	87	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		CAGAGACGAAGGGACCACTAT	0.358000													17	36					0	0	1	0	0
SLC39A1	27173	broad.mit.edu	37	1	153932929	153932929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153932929G>A	ENST00000368623.3	-	3	1379	c.620C>T	c.(619-621)gCc>gTc	p.A207V	SLC39A1_ENST00000356205.4_Missense_Mutation_p.A207V|SLC39A1_ENST00000537590.1_Missense_Mutation_p.A105V|SLC39A1_ENST00000310483.6_Missense_Mutation_p.A207V|SLC39A1_ENST00000368621.1_Missense_Mutation_p.A207V			Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter), member 1	207						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		CAGCTCCATGGCCCGAGCCCG	0.662000													15	34					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40554830	40554830	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:40554830G>A	ENST00000297737.6	-	4	429	c.283C>T	c.(283-285)Caa>Taa	p.Q95*	ZMAT4_ENST00000315769.7_Nonsense_Mutation_p.Q95*	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	95						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			ATTTTGCCTTGATAATGGGAA	0.517000													43	123					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212798854	212798854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:212798854G>A	ENST00000294829.3	+	1	1066	c.635G>A	c.(634-636)gGa>gAa	p.G212E	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	212										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		AACCTTCAAGGAAAGGGGGAT	0.562000													38	96					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62547881	62547881	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:62547881G>A	ENST00000430451.2	+	4	1520	c.1323G>A	c.(1321-1323)cgG>cgA	p.R441R		NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	441	C2 1.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		ACGCTGCCCGGAAGATGACCC	0.567000													11	31					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47371532	47371532	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47371532C>T	ENST00000232766.5	+	4	513	c.493C>T	c.(493-495)Cag>Tag	p.Q165*	KLHL18_ENST00000455924.2_Nonsense_Mutation_p.Q53*	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	165	BACK.									endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CTTCATCCACCAGCACTTTGT	0.532000													29	88					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89391820	89391820	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:89391820G>A	ENST00000532352.1	+	0	436							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TGCACGAACTGAAGACTTCTT	0.368000													13	27					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73522254	73522254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73522254C>T	ENST00000418310.1	+	9	1311	c.1209C>T	c.(1207-1209)ttC>ttT	p.F403F	LIMK1_ENST00000336180.2_Silent_p.F373F|LIMK1_ENST00000538333.3_Silent_p.F339F			P53667	LIMK1_HUMAN	LIM domain kinase 1	373	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding	p.F373F(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				TGATCCGGTTCGACGAGGAGA	0.582000													3	4					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513509	99513509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:99513509G>A	ENST00000261037.3	+	5	1144	c.764G>A	c.(763-765)gGg>gAg	p.G255E	COL8A1_ENST00000273342.4_Missense_Mutation_p.G255E	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	255	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGTGTAAAGGGGCCTCCAGGG	0.647000													40	72					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115526432	115526432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115526432C>T	ENST00000361048.1	+	4	506	c.179C>T	c.(178-180)tCc>tTc	p.S60F	PLEKHS1_ENST00000369312.4_5'UTR|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.S54F	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		TTTAGTCTTTCCTATTATAAA	0.338000													32	86					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701923	56701923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56701923C>T	ENST00000586855.2	-	5	1074	c.761G>A	c.(760-762)gGg>gAg	p.G254E	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.G254E			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	254					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GGGTTCCTTCCCCTCCTTTGC	0.483000													38	81					0	0	1	0	0
SIRPB2	284759	broad.mit.edu	37	20	1459186	1459186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1459186C>T	ENST00000359801.3	-	3	554	c.518G>A	c.(517-519)gGa>gAa	p.G173E	SIRPB2_ENST00000537284.1_Missense_Mutation_p.G35E|SIRPB2_ENST00000381630.1_Missense_Mutation_p.G75E|SIRPB2_ENST00000444444.1_Missense_Mutation_p.G75E	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	173	Ig-like V-type 2.					integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GACAGTGTCTCCAGTGGTCCC	0.577000													19	50					0	0	1	0	0
OR11A1	26531	broad.mit.edu	37	6	29395302	29395302	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29395302G>A	ENST00000377149.1	-	5	589	c.117C>T	c.(115-117)ttC>ttT	p.F39F	OR11A1_ENST00000377148.1_Silent_p.F39F|OR11A1_ENST00000377147.2_Silent_p.F39F|OR5V1_ENST00000377154.1_Intron			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						CTATGATGATGAAGACATAGA	0.403000													32	53					0	0	1	0	0
FCN3	8547	broad.mit.edu	37	1	27700886	27700886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27700886G>A	ENST00000270879.4	-	2	153	c.148C>T	c.(148-150)Cca>Tca	p.P50S	FCN3_ENST00000354982.2_Missense_Mutation_p.P50S	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3	50	Collagen-like.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GGACTTCCTGGAGCTCCGGGA	0.617000													12	52					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176708876	176708876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176708876C>T	ENST00000367662.3	+	13	5077	c.3913C>T	c.(3913-3915)Cgt>Tgt	p.R1305C		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1305					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GACCGATGTCCGTGGAAGCAA	0.493000													25	59					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77409717	77409717	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:77409717G>A	ENST00000308488.6	-	7	2832	c.2530C>T	c.(2530-2532)Cga>Tga	p.R844*	RSF1_ENST00000480887.1_Nonsense_Mutation_p.R592*|RSF1_ENST00000360355.2_Nonsense_Mutation_p.R813*			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	844					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding	p.R844*(1)		breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CCAGTCCATCGAACTTTGCCT	0.368000													38	154					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46129491	46129491	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46129491C>T	ENST00000371383.2	-	5	1267		c.e5-1		ENPP5_ENST00000230565.3_Splice_Site			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)							extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						TGGTTGCCTACTGTAAAGAGA	0.353000													51	222					0	0	1	0	0
ZNF763	284390	broad.mit.edu	37	19	12089447	12089447	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12089447C>T	ENST00000343949.5	+	4	872	c.717C>T	c.(715-717)tcC>tcT	p.S239S	ZNF763_ENST00000590798.1_Silent_p.S256S|ZNF763_ENST00000538752.1_Silent_p.S256S|ZNF763_ENST00000545530.1_Silent_p.S114S|ZNF763_ENST00000358987.3_Silent_p.S236S	NM_001012753.1	NP_001012771.1			zinc finger protein 763											central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)	15						GTGTTAAATCCTTTAGTTATT	0.378000													28	84					0	0	1	0	0
HAP1	9001	broad.mit.edu	37	17	39890852	39890852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39890852C>T	ENST00000393939.2	-	1	44	c.35G>A	c.(34-36)gGg>gAg	p.G12E	HAP1_ENST00000347901.4_Missense_Mutation_p.G12E|HAP1_ENST00000310778.5_Missense_Mutation_p.G12E|HAP1_ENST00000341193.5_Missense_Mutation_p.G12E|JUP_ENST00000540235.1_Intron			P54257	HAP1_HUMAN	huntingtin-associated protein 1	12					brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			GAGCCGGCTCCCCGCGCAGCA	0.736000													3	5					0	0	1	0	0
SSX3	10214	broad.mit.edu	37	X	48206962	48206962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48206962C>T	ENST00000298396.2	-	7	596	c.544G>A	c.(544-546)Gat>Aat	p.D182N	SSX3_ENST00000376895.1_Missense_Mutation_p.D94N	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						TCCTCAGGATCGCTGATCTCT	0.483000													166	125					0	0	1	0	0
C4orf17	84103	broad.mit.edu	37	4	100463110	100463110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100463110G>A	ENST00000326581.4	+	9	1286	c.924G>A	c.(922-924)atG>atA	p.M308I		NM_032149.2	NP_115525.2	Q53FE4	CD017_HUMAN	chromosome 4 open reading frame 17	308										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		GAAATAATATGAAAATACCTG	0.388000													18	39					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47364527	47364527	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47364527G>A	ENST00000505841.1	-	0	309					NR_002788.2																						TGTCTTTTCAGGAGAATCTTG	0.478000													39	70					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649612	75649612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:75649612C>T	ENST00000361470.2	+	1	1567	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	430						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						TCCAAGTGTTCCCTTGTTTTG	0.572000													10	20					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175046902	175046902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175046902G>A	ENST00000239462.4	+	2	461	c.348G>A	c.(346-348)gaG>gaA	p.E116E		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	116					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix		p.E116D(1)		NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGAAGCTGGAGGAAGAGATGG	0.552000													12	37					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86542418	86542418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86542418C>T	ENST00000450689.2	-	14	2019	c.1834G>A	c.(1834-1836)Gaa>Aaa	p.E612K	KIAA1324L_ENST00000490995.1_5'UTR|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.E372K|KIAA1324L_ENST00000416314.1_Missense_Mutation_p.E445K|KIAA1324L_ENST00000444627.1_Intron	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	612						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					CCCGACTGTTCAGAACCGAGG	0.517000													12	58					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150267064	150267064	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150267064T>A	ENST00000461940.1	+	2	158	c.75T>A	c.(73-75)agT>agA	p.S25R	GIMAP4_ENST00000255945.2_Intron|GIMAP4_ENST00000494750.1_Intron			Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	20							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGCATTCAGTGCTCCCCAGA	0.592000													10	54					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105344435	105344435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105344435G>A	ENST00000369780.4	+	4	1201	c.792G>A	c.(790-792)gaG>gaA	p.E264E	NEURL_ENST00000369777.2_Silent_p.E247E	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		264					nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ACGGCGACGAGGCCGCGCCGG	0.761000													3	7					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195490982	195490982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:195490982G>A	ENST00000463781.3	-	11	14437	c.13978C>T	c.(13978-13980)Ctc>Ttc	p.L4660F	MUC4_ENST00000475231.1_Missense_Mutation_p.L4608F|MUC4_ENST00000346145.4_Missense_Mutation_p.L424F|MUC4_ENST00000349607.4_Missense_Mutation_p.L373F	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1417					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGGCACAGAGGTAGGGCTTG	0.657000													4	6					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20846357	20846357	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20846357G>A	ENST00000262715.5	-	39	5587	c.5547C>T	c.(5545-5547)gcC>gcT	p.A1849A	TEP1_ENST00000556935.1_Silent_p.A1741A|TEP1_ENST00000545983.1_Silent_p.A187A	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1849					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GCACATTGAAGGCCAAGGTAC	0.617000													31	77					0	0	1	0	0
JADE3	9767	broad.mit.edu	37	X	46913813	46913813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:46913813C>T	ENST00000218343.4	+	9	1524	c.1226C>T	c.(1225-1227)tCc>tTc	p.S409F	PHF16_ENST00000397189.1_Missense_Mutation_p.S409F	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		409					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						GAGTTCTATTCCTTGGTACGA	0.532000													23	21					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73545474	73545474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73545474G>A	ENST00000224721.6	+	43	5819	c.5814G>A	c.(5812-5814)gaG>gaA	p.E1938E		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1933	Cadherin 18.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACAACCCGGAGAATCCACGCA	0.612000													5	16					0	0	1	0	0
PHRF1	57661	broad.mit.edu	37	11	609451	609451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:609451C>T	ENST00000264555.5	+	14	4123	c.3995C>T	c.(3994-3996)tCg>tTg	p.S1332L	PHRF1_ENST00000416188.2_Missense_Mutation_p.S1331L|PHRF1_ENST00000413872.2_Missense_Mutation_p.S1330L|PHRF1_ENST00000533464.1_Missense_Mutation_p.S1328L	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1332							RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						GAAGACCCTTCGCAGCCCCCA	0.672000													6	26					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146807307	146807307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:146807307G>A	ENST00000508784.1	-	4	1497	c.1270C>T	c.(1270-1272)Cat>Tat	p.H424Y	ZNF827_ENST00000513320.1_Missense_Mutation_p.H74Y|ZNF827_ENST00000379448.4_Missense_Mutation_p.H424Y			Q17R98	ZN827_HUMAN	zinc finger protein 827	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TGGTGCTGATGAACCTGACGG	0.502000													7	17					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3002618	3002618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3002618C>T	ENST00000381127.1	+	6	962	c.741C>T	c.(739-741)ctC>ctT	p.L247L	ARSF_ENST00000359361.2_Silent_p.L247L|ARSF_ENST00000537104.1_Silent_p.L247L	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	247						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACTGCCTCCTCATGCGGGGGC	0.507000													36	25					0	0	1	0	0
GRK5	2869	broad.mit.edu	37	10	121189921	121189921	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:121189921C>T	ENST00000392870.2	+	7	897	c.568C>T	c.(568-570)Cga>Tga	p.R190*	GRK5_ENST00000369108.3_Nonsense_Mutation_p.R85*	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	190	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		CAGGCAGTATCGAGTGCTAGG	0.458000													49	108					0	0	1	0	0
ARGLU1	55082	broad.mit.edu	37	13	107220265	107220265	+	Translation_Start_Site	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:107220265C>A	ENST00000400198.3	-	1	247	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_018011.3	NP_060481.3	Q9NWB6	ARGL1_HUMAN	arginine and glutamate rich 1	1										large_intestine(1)|lung(5)|pancreas(1)	7	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					GAGACCGGCCCATCCTTCCGG	0.697000													10	34					0.000978159	0.000979301	1	1	0
EPHA8	2046	broad.mit.edu	37	1	22927862	22927862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22927862C>T	ENST00000166244.3	+	16	2871	c.2799C>T	c.(2797-2799)ctC>ctT	p.L933L		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	933	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GTGGGGGCCTCACCGTGGGGG	0.677000													15	63					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32636038	32636038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:32636038C>T	ENST00000335185.5	-	16	1869	c.1826G>A	c.(1825-1827)gGg>gAg	p.G609E		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	609										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					TTCTCGAGTCCCTGGAAGCAA	0.333000													14	36					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003736	34003736	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34003736C>T	ENST00000374181.3	-	8	2320	c.2151G>A	c.(2149-2151)tgG>tgA	p.W717*	GRM4_ENST00000535756.1_Nonsense_Mutation_p.W584*|GRM4_ENST00000374177.3_Nonsense_Mutation_p.W601*|GRM4_ENST00000538487.1_Nonsense_Mutation_p.W717*|GRM4_ENST00000545715.1_Nonsense_Mutation_p.W409*|GRM4_ENST00000455714.2_Nonsense_Mutation_p.W577*|GRM4_ENST00000544773.1_Nonsense_Mutation_p.W548*	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	717					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CCACCACAAACCACACACAGA	0.642000													18	109					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27684701	27684701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27684701G>A	ENST00000493901.1	-	22	3125	c.2886C>T	c.(2884-2886)tgC>tgT	p.C962C	MAP3K6_ENST00000357582.2_Silent_p.C962C|MAP3K6_ENST00000374040.3_Silent_p.C954C	NM_004672.3	NP_004663.3	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	962					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CATAACTGAGGCAGCGCTTCG	0.607000											OREG0013282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	50					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474657	140474657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140474657G>A	ENST00000194155.4	+	1	431	c.283G>A	c.(283-285)Gag>Aag	p.E95K		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		95	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTGGACCGGGAGGAGCTGTG	0.512000													28	96					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234094533	234094533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234094533G>A	ENST00000359570.5	+	23	2284	c.2284G>A	c.(2284-2286)Ggg>Agg	p.G762R	INPP5D_ENST00000455936.2_Missense_Mutation_p.G526R|INPP5D_ENST00000450745.1_Missense_Mutation_p.G526R			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	774					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AGGAAGTGAGGGGGAGCTGGT	0.458000													7	23					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47841689	47841689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47841689G>A	ENST00000371764.4	+	6	655	c.646G>A	c.(646-648)Gaa>Aaa	p.E216K	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	216						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCAGTACGATGAAAACCTCTC	0.418000													37	120					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47628967	47628967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:47628967C>T	ENST00000546455.1	+	4	852	c.121C>T	c.(121-123)Cgc>Tgc	p.R41C	PCED1B_ENST00000432328.1_Missense_Mutation_p.R41C					PC-esterase domain containing 1B																		GCAGAAGGACCGCCTGCTCAC	0.597000													5	37					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211624	38211624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38211624C>T	ENST00000379705.3	-	11	3207	c.2350G>A	c.(2350-2352)Gaa>Aaa	p.E784K	TRPC4_ENST00000358477.2_Missense_Mutation_p.E784K|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000379673.2_Missense_Mutation_p.E719K|TRPC4_ENST00000338947.5_Missense_Mutation_p.E611K|TRPC4_ENST00000355779.2_Intron|TRPC4_ENST00000379679.1_Missense_Mutation_p.E611K|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379681.3_Missense_Mutation_p.E789K			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	784	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CTATTACCTTCGCTATCACTC	0.413000													39	92					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294157	25294157	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25294157G>A	ENST00000400358.4	+	19	2298	c.2241G>A	c.(2239-2241)acG>acA	p.T747T	SGSM1_ENST00000400359.4_Silent_p.T802T	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	802	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						ACACCCCCACGGTGCTGCGAC	0.627000													13	66					0	0	1	0	0
ATRIP	84126	broad.mit.edu	37	3	48501206	48501206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48501206C>T	ENST00000412052.1	+	7	1129	c.667C>T	c.(667-669)Ctc>Ttc	p.L223F	ATRIP_ENST00000346691.4_Missense_Mutation_p.L316F|ATRIP_ENST00000357105.6_Missense_Mutation_p.L189F|ATRIP_ENST00000320211.3_Missense_Mutation_p.L316F	NM_001271023.1	NP_001257952.1	Q8WXE1	ATRIP_HUMAN	ATR interacting protein	316					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)	22				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GATAAACCTGCTCCTGAAGCA	0.507000								Other conserved DNA damage response genes					49	210					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168096465	168096465	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168096465G>A	ENST00000409195.1	+	6	1048	c.959G>A	c.(958-960)gGa>gAa	p.G320E	XIRP2_ENST00000420519.1_Missense_Mutation_p.G353E|XIRP2_ENST00000409756.2_Missense_Mutation_p.G320E|XIRP2_ENST00000409043.1_Missense_Mutation_p.G320E|XIRP2_ENST00000409728.1_Missense_Mutation_p.G353E|XIRP2_ENST00000295237.9_Missense_Mutation_p.G320E|XIRP2_ENST00000409605.1_Missense_Mutation_p.G98E|XIRP2_ENST00000409273.1_Missense_Mutation_p.G98E	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	145					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATGTTCATGGAACAGAAATG	0.388000													22	35					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70933760	70933760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70933760C>T	ENST00000334414.6	-	24	5681	c.5637G>A	c.(5635-5637)agG>agA	p.R1879R	PTPRB_ENST00000550857.1_Silent_p.R1571R|PTPRB_ENST00000451516.2_Silent_p.R1571R|PTPRB_ENST00000550358.1_Silent_p.R1791R|PTPRB_ENST00000538708.1_Silent_p.R1571R|PTPRB_ENST00000261266.5_Silent_p.R1661R	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1661	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.R1661S(2)|p.R1879S(1)		breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATGGTCGATCCCTACGAATGC	0.408000													16	36					0	0	1	0	0
TRBV25-1	28562	broad.mit.edu	37	7	142378908	142378908	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142378908G>A	ENST00000390398.3	+	0	213																											CAAGATCCAGGAATGGAACTA	0.438000													49	110					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624553	123624553	+	Missense_Mutation	SNP	C	C	T	rs140203672	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123624553C>T	ENST00000327930.2	-	1	700	c.674G>A	c.(673-675)cGa>cAa	p.R225Q		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGAAGGAATTCGTAGGATTGC	0.473000													38	76					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13920608	13920608	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13920608C>T	ENST00000265104.4	-	6	883	c.779G>A	c.(778-780)tGg>tAg	p.W260*		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	260	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTGTTTGATCCATACTTTCAT	0.398000									Kartagener syndrome				32	100					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17422640	17422640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17422640G>A	ENST00000470360.1	+	14	2196	c.2079G>A	c.(2077-2079)aaG>aaA	p.K693K	SLC7A2_ENST00000494857.1_Silent_p.K654K|SLC7A2_ENST00000522656.1_Silent_p.K654K|SLC7A2_ENST00000398090.3_Silent_p.K693K|SLC7A2_ENST00000004531.10_Silent_p.K694K			P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	654					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	TCCATGAAAAGACAAGTGAAT	0.433000													13	26					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29008201	29008201	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29008201G>A	ENST00000282397.4	-	5	921	c.670C>T	c.(670-672)Cga>Tga	p.R224*	FLT1_ENST00000539099.1_Nonsense_Mutation_p.R224*|FLT1_ENST00000541932.1_Nonsense_Mutation_p.R224*	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	224					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TTACTTTGTCGATGTGTGAGA	0.353000													24	77					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189863437	189863437	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189863437G>A	ENST00000304636.3	+	29	2185	c.2015G>A	c.(2014-2016)gGa>gAa	p.G672E	COL3A1_ENST00000317840.5_Missense_Mutation_p.G672E	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	672	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGAGCTCCAGGAGGCAAGGTA	0.383000													21	41					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254511	30254511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:30254511C>T	ENST00000361644.2	+	5	1207	c.470C>T	c.(469-471)tCt>tTt	p.S157F	MAGEB3_ENST00000378986.1_Missense_Mutation_p.S157F	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	157	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						AAAAAAGCTTCTTTCAACATG	0.373000													52	20					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46125901	46125901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46125901G>A	ENST00000295452.4	-	1	197	c.30C>T	c.(28-30)tcC>tcT	p.S10S		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	10					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		GAAGAAAAGGGGAGAAGAGAA	0.473000													6	48					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113496530	113496530	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113496530G>A	ENST00000416899.2	+	6	754		c.e6-1		MUSK_ENST00000189978.5_Splice_Site|MUSK_ENST00000374448.4_Splice_Site			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						CTTCCTAACAGTTTTTGCCAG	0.507000													5	17					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45387767	45387767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45387767C>T	ENST00000389039.6	-	31	4492	c.4107G>A	c.(4105-4107)gaG>gaA	p.E1369E	DUOX2_ENST00000603300.1_Silent_p.E1369E			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1369	FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CCTGATGGCCCTCTCCAAACG	0.562000													23	60					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759414	121759414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121759414G>A	ENST00000261367.7	+	6	2551	c.1123G>A	c.(1123-1125)Gaa>Aaa	p.E375K	SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E375K|SNCAIP_ENST00000503116.2_Missense_Mutation_p.E375K|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E328K|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E328K|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000504884.2_Intron			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	328					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CATTGTTAAAGAAGGACAGAT	0.408000													20	71					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38723748	38723748	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38723748G>A	ENST00000359357.3	+	8	1011	c.756_splice	c.e8-1	p.V253_splice	DNAH8_ENST00000449981.2_Splice_Site_p.V470_splice|DNAH8_ENST00000441566.1_Splice_Site_p.V253_splice					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TCAATGTTAGGTTTCCATGGC	0.303000													23	52					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922361	24922361	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922361A>G	ENST00000329468.2	+	1	1821	c.1347A>G	c.(1345-1347)aaA>aaG	p.K449K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCACACCAAAAATGGATGAGA	0.507000													55	113					0	0	1	0	0
ELAVL3	1995	broad.mit.edu	37	19	11567934	11567934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11567934C>T	ENST00000359227.3	-	6	1167	c.743G>A	c.(742-744)gGc>gAc	p.G248D	ELAVL3_ENST00000438662.2_Missense_Mutation_p.G248D	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	248				G -> A (in Ref. 4; BAA21838).	cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						CCTCTTGACGCCGTAGGCCAT	0.647000													3	15					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48119606	48119606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48119606G>A	ENST00000311303.3	-	27	4071	c.3726C>T	c.(3724-3726)ctC>ctT	p.L1242L	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_3'UTR|ABCC12_ENST00000532355.1_5'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1242	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				ATTTTTCTGGGAGTTTCATTA	0.408000													28	129					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105252525	105252525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:105252525C>T	ENST00000306107.5	+	5	1038	c.538C>T	c.(538-540)Ctt>Ttt	p.L180F	ALCAM_ENST00000389927.4_5'UTR|ALCAM_ENST00000486979.2_Missense_Mutation_p.L129F|ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000472644.2_Missense_Mutation_p.L180F	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	180	Ig-like V-type 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						GCTACATCCCCTTGAAGGAGG	0.448000													29	90					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38884057	38884057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38884057G>A	ENST00000274276.3	+	5	949	c.547G>A	c.(547-549)Ggg>Agg	p.G183R	OSMR_ENST00000502536.1_Missense_Mutation_p.G183R	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	183					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TTATTTGGAAGGGAAACAGAT	0.363000													28	106					0	0	1	0	0
ANKZF1	55139	broad.mit.edu	37	2	220099597	220099597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220099597G>A	ENST00000323348.5	+	10	1428	c.1254G>A	c.(1252-1254)gtG>gtA	p.V418V	ANKZF1_ENST00000410034.3_Silent_p.V418V|ANKZF1_ENST00000409849.1_Silent_p.V208V	NM_018089.2	NP_060559.2	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing 1	418						intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	23		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGAGCTAGTGGAGTTGACTG	0.498000													17	64					0	0	1	0	0
MED1	5469	broad.mit.edu	37	17	37580070	37580070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37580070G>A	ENST00000300651.6	-	12	1079	c.856C>T	c.(856-858)Cct>Tct	p.P286S	MED1_ENST00000394287.3_Missense_Mutation_p.P286S	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	286	Interaction with ESR1.|Interaction with the Mediator complex and THRA.|Interaction with the Mediator complex.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GAGAAGGAAGGGGTCCTTCAA	0.403000										HNSCC(31;0.082)			28	29					0	0	1	0	0
PIK3C3	5289	broad.mit.edu	37	18	39542544	39542544	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:39542544C>T	ENST00000262039.4	+	3	434	c.348C>T	c.(346-348)ccC>ccT	p.P116P	PIK3C3_ENST00000586545.1_Silent_p.P116P|PIK3C3_ENST00000398870.3_Silent_p.P53P	NM_002647.2	NP_002638.2	Q8NEB9	PK3C3_HUMAN	phosphatidylinositol 3-kinase, catalytic subunit type 3	116					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(25)|ovary(1)|skin(2)|urinary_tract(1)	49						TGTATGGTCCCGGAAAAGCAG	0.483000										TSP Lung(28;0.18)			22	83					0	0	1	0	0
GDPGP1	390637	broad.mit.edu	37	15	90784905	90784905	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90784905C>T	ENST00000558017.1	+	4	1185	c.765C>T	c.(763-765)ttC>ttT	p.F255F	GDPGP1_ENST00000329600.6_Silent_p.F255F	NM_001013657.2	NP_001013679.2	Q6ZNW5	VTC2_HUMAN	GDP-D-glucose phosphorylase 1	255					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity										CTCCTGGCTTCCTCTTTTACA	0.577000													12	72					0	0	1	0	0
RSL1D1	26156	broad.mit.edu	37	16	11931783	11931783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11931783G>A	ENST00000571133.1	-	9	1406	c.1334C>T	c.(1333-1335)tCg>tTg	p.S445L	RSL1D1_ENST00000542106.1_Missense_Mutation_p.S225L	NM_015659.2	NP_056474.2	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	445					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	15						tttccccagcgaaggactttt	0.478000													151	281					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69796941	69796941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69796941C>T	ENST00000251566.4	-	4	1046	c.1016G>A	c.(1015-1017)gGa>gAa	p.G339E	UGT2A3_ENST00000420231.2_Missense_Mutation_p.G50E	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	339						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TGGTTTTTTTCCTTTGTACCT	0.358000													24	51					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94674845	94674845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94674845C>T	ENST00000304338.3	+	3	390	c.236C>T	c.(235-237)cCa>cTa	p.P79L	PPP4R4_ENST00000555690.1_3'UTR|PPP4R4_ENST00000328839.3_Missense_Mutation_p.P79L	NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	79						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GCAAATCTCCCATTTTTGATG	0.378000													15	51					0	0	1	0	0
RAB2B	84932	broad.mit.edu	37	14	21930572	21930572	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21930572G>A	ENST00000397762.1	-	7	580	c.480C>T	c.(478-480)ttC>ttT	p.F160F	RAB2B_ENST00000461909.1_5'UTR	NM_001163380.1|NM_032846.3	NP_001156852.1|NP_116235.2	Q8WUD1	RAB2B_HUMAN	RAB2B, member RAS oncogene family	160					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		CTGTGTTAATGAAGGCCTGAA	0.358000													42	107					0	0	1	0	0
UPK1B	7348	broad.mit.edu	37	3	118909895	118909895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:118909895G>A	ENST00000264234.3	+	5	561	c.412G>A	c.(412-414)Gat>Aat	p.D138N	UPK1B_ENST00000460625.1_Missense_Mutation_p.D130N|UPK1B_ENST00000497685.1_Missense_Mutation_p.D58N	NM_006952.3	NP_008883.2	O75841	UPK1B_HUMAN	uroplakin 1B	138					epithelial cell differentiation	integral to membrane	structural molecule activity			breast(1)|endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	14				GBM - Glioblastoma multiforme(114;0.222)		TCCAAACAATGATGACCAGTG	0.478000													122	255					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73535261	73535261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73535261C>T	ENST00000418310.1	+	15	1855	c.1753C>T	c.(1753-1755)Cgc>Tgc	p.R585C	LIMK1_ENST00000538333.3_Missense_Mutation_p.R521C|LIMK1_ENST00000336180.2_Missense_Mutation_p.R555C			P53667	LIMK1_HUMAN	LIM domain kinase 1	555	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				CTACCTGCCCCGCACCATGGA	0.647000													74	130					0	0	1	0	0
ZC3H11A	9877	broad.mit.edu	37	1	203798606	203798606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203798606C>T	ENST00000545588.1	+	5	4153	c.326C>T	c.(325-327)cCa>cTa	p.P109L	ZC3H11A_ENST00000367214.1_Missense_Mutation_p.P109L|ZC3H11A_ENST00000332127.4_Missense_Mutation_p.P109L|ZC3H11A_ENST00000367212.3_Missense_Mutation_p.P109L|ZC3H11A_ENST00000367210.1_Missense_Mutation_p.P109L	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	109							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTGAGTCACCAGAAGAGGAA	0.448000													31	80					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50366977	50366977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50366977G>A	ENST00000315520.5	+	1	358	c.21G>A	c.(19-21)ggG>ggA	p.G7G	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	7					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						TGGAGCCAGGGGGACGTGGCT	0.592000													8	43					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55144467	55144467	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55144467G>A	ENST00000396331.1	+	8	1316	c.958_splice	c.e8-1	p.G320_splice	LILRB1_ENST00000427581.2_Splice_Site_p.G356_splice|LILRB1_ENST00000434867.2_Splice_Site_p.G320_splice|LILRB1_ENST00000396315.1_Splice_Site_p.G320_splice|LILRB1_ENST00000448689.1_Splice_Site_p.G320_splice|LILRB1_ENST00000418536.2_Splice_Site_p.G320_splice|LILRB1_ENST00000396321.2_Splice_Site_p.G320_splice|LILRB1_ENST00000324602.7_Splice_Site_p.G320_splice|LILRB1_ENST00000396317.1_Splice_Site_p.G320_splice|LILRB1_ENST00000396332.4_Splice_Site_p.G320_splice|LILRB1_ENST00000396327.3_Splice_Site_p.G320_splice	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	320	Ig-like C2-type 4.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TTCTCTCCAGGACAGTTCTAT	0.607000										HNSCC(37;0.09)			14	87					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40746003	40746003	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40746003C>T	ENST00000216194.7	+	2	377	c.321C>T	c.(319-321)caC>caT	p.H107H	ADSL_ENST00000342312.6_Silent_p.H107H|ADSL_ENST00000454266.2_Silent_p.H107H	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	107					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						GCATTATTCACCTTGGTGCTA	0.423000													21	88					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187206877	187206877	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187206877C>T	ENST00000264692.4	+	12	1567	c.1234C>T	c.(1234-1236)Caa>Taa	p.Q412*	F11_ENST00000403665.2_Nonsense_Mutation_p.Q464*			P03951	FA11_HUMAN	coagulation factor XI	464	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	CTTTGGGGTTCAAGAAATAAT	0.378000													56	92					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49697935	49697935	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49697935C>T	ENST00000296452.4	+	6	8771	c.8657C>T	c.(8656-8658)cCc>cTc	p.P2886L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2886					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCGTTGCCACCCAACAGCCTG	0.657000													40	141					0	0	1	0	0
SPATA31A3	727830	broad.mit.edu	37	9	40702809	40702809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:40702809G>A	ENST00000356699.5	+	4	495	c.466G>A	c.(466-468)Gat>Aat	p.D156N	SPATA31A3_ENST00000463536.1_3'UTR	NM_001083124.1	NP_001076593.1			SPATA31 subfamily A, member 3									p.D156N(2)									AGCTTCCCCGGATCCTCAAGC	0.597000													56	260					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620855	7620855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:7620855C>T	ENST00000486284.1	+	8	2536	c.2262C>T	c.(2260-2262)ctC>ctT	p.L754L	GRM7_ENST00000357716.4_Silent_p.L754L|GRM7_ENST00000403881.1_Silent_p.L754L|GRM7_ENST00000402647.2_Silent_p.L754L|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000389336.4_Silent_p.L754L	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	754					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TTACAGATCTCCAAATCATTT	0.443000													39	79					0	0	1	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3392325	3392325	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:3392325C>G	ENST00000324266.5	+	2	1126	c.931C>G	c.(931-933)Ctt>Gtt	p.L311V	TRAPPC12_ENST00000382110.2_Missense_Mutation_p.L311V	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	311							binding										CGACGCCTGGCTTCCCGGCGA	0.672000													10	32					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16060702	16060702	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16060702G>A	ENST00000322107.1	+	1	885	c.885G>A	c.(883-885)agG>agA	p.R295R		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						TCAGCCTAAGGAACAAGGAGC	0.438000													69	104					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158581078	158581078	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158581078G>A	ENST00000368148.3	-	52	7416	c.7236C>T	c.(7234-7236)ttC>ttT	p.F2412F	SPTA1_ENST00000368147.3_Silent_p.F2409F	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2412				GRSHLSGYDYVGFTNSYFGN -> VEAISLAMTTLASPIPT LATNKQLLVDRRKS (in Ref. 1; AAA60577/ AAA60994).	actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGGAATTGGTGAAGCCAACGT	0.483000													15	45					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86537848	86537848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86537848C>T	ENST00000450689.2	-	17	2556	c.2371G>A	c.(2371-2373)Gaa>Aaa	p.E791K	KIAA1324L_ENST00000297222.6_Missense_Mutation_p.E551K|KIAA1324L_ENST00000416314.1_Missense_Mutation_p.E624K|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.E720K	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	791						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					AATGTGGTTTCAACTGTGACT	0.289000													34	63					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12496026	12496026	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:12496026C>T	ENST00000535902.1	-	2	786	c.223_splice	c.e2+1	p.G75_splice	MANSC1_ENST00000396349.3_Splice_Site_p.G41_splice			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	75	MANSC.					integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CACTATTTACCTGATATGTTT	0.418000													37	78					0	0	1	0	0
C1GALT1	56913	broad.mit.edu	37	7	7283191	7283191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:7283191C>T	ENST00000436587.2	+	4	1148	c.925C>T	c.(925-927)Cac>Tac	p.H309Y	C1GALT1_ENST00000223122.2_Missense_Mutation_p.H309Y	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	309					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		AGTTTCTTTTCACTATGTTGA	0.358000													34	160					0	0	1	0	0
SMAD6	4091	broad.mit.edu	37	15	67073803	67073803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:67073803C>T	ENST00000288840.5	+	4	2452	c.1421C>T	c.(1420-1422)cCc>cTc	p.P474L	SMAD6_ENST00000338426.4_Missense_Mutation_p.P213L	NM_005585.4	NP_005576.3	O43541	SMAD6_HUMAN	SMAD family member 6	474	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			lung(1)|skin(1)	2						GGCTGGGGGCCCTGCTACTCC	0.716000													7	32					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75289544	75289544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75289544G>A	ENST00000339859.4	-	14	2054	c.1954C>T	c.(1954-1956)Ccc>Tcc	p.P652S	USP54_ENST00000319786.7_Missense_Mutation_p.P652S|USP54_ENST00000497106.1_5'UTR|USP54_ENST00000394811.2_5'UTR|USP54_ENST00000428547.1_Missense_Mutation_p.P502S|USP54_ENST00000408019.1_Missense_Mutation_p.P652S			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	652					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					ATTAGTCGGGGGTGCTGCTCT	0.557000											OREG0020266	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	199					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38963059	38963059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38963059G>A	ENST00000357387.3	-	17	1515	c.1485C>T	c.(1483-1485)gaC>gaT	p.D495D	RICTOR_ENST00000296782.5_Silent_p.D495D	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	495					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					GAATAATGTGGTCTAAATGAA	0.393000													27	86					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30202214	30202214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30202214G>A	ENST00000397771.2	-	13	1328	c.1151C>T	c.(1150-1152)tCa>tTa	p.S384L	ASCC2_ENST00000542393.1_Missense_Mutation_p.S308L|ASCC2_ENST00000478812.1_5'UTR|ASCC2_ENST00000307790.3_Missense_Mutation_p.S384L			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			CAAGACTGATGAGGCCTGCTG	0.567000													26	60					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161132108	161132108	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161132108G>C	ENST00000308192.9	+	4	355		c.e4-1		PLG_ENST00000462918.1_Splice_Site|PLG_ENST00000366924.2_Splice_Site	NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen						extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CTTCCCTTCAGTGTATCTCTC	0.453000													20	24					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18788727	18788727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18788727G>A	ENST00000406451.3	+	14	2150	c.2000G>A	c.(1999-2001)cGa>cAa	p.R667Q	HDAC9_ENST00000441542.2_Missense_Mutation_p.R670Q|HDAC9_ENST00000432645.2_Missense_Mutation_p.R667Q|HDAC9_ENST00000401921.1_Missense_Mutation_p.R626Q	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	667	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity	p.R670L(2)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	ATCTGGTCACGACTGCAAGAA	0.438000													7	16					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8807902	8807902	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8807902C>T	ENST00000324436.3	-	1	1270	c.1150G>A	c.(1150-1152)Ggc>Agc	p.G384S		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	384						cytoplasm|cytoskeleton		p.G384S(1)		NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						AGGATGGAGCCCCCGATCCAT	0.652000													14	44					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82644813	82644813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:82644813C>T	ENST00000533655.1	+	6	2645	c.2433C>T	c.(2431-2433)ttC>ttT	p.F811F	C11orf82_ENST00000329143.3_Silent_p.F510F|C11orf82_ENST00000430323.2_Silent_p.F811F|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	811					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TAAGGATTTTCCCTGAAAATG	0.368000													14	32					0	0	1	0	0
HSD11B1	3290	broad.mit.edu	37	1	209879200	209879200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209879200G>A	ENST00000367028.2	+	3	302	c.133G>A	c.(133-135)Ggg>Agg	p.G45R	RP1-28O10.1_ENST00000441672.1_RNA|HSD11B1_ENST00000367027.3_Missense_Mutation_p.G45R|HSD11B1_ENST00000261465.1_Missense_Mutation_p.G45R	NM_001206741.1	NP_001193670.1	P28845	DHI1_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1	45					glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	16				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	GGCCAGCAAAGGGATCGGAAG	0.502000													34	69					0	0	1	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51768752	51768752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51768752G>A	ENST00000316401.7	+	3	534	c.153G>A	c.(151-153)atG>atA	p.M51I	SIGLECL1_ENST00000597824.1_Intron|SIGLECL1_ENST00000593968.1_Intron|CTD-3187F8.2_ENST00000597569.1_RNA	NM_173635.1	NP_775906.1			SIGLEC family like 1																		TGGATGGCATGGATGGCAGCC	0.572000													32	56					0	0	1	0	0
SMAD7	4092	broad.mit.edu	37	18	46447991	46447991	+	Silent	SNP	G	G	A	rs143946125	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:46447991G>A	ENST00000262158.2	-	4	1318	c.1032C>T	c.(1030-1032)tcC>tcT	p.S344S	SMAD7_ENST00000589634.1_Silent_p.S343S|SMAD7_ENST00000591805.1_Silent_p.S129S|SMAD7_ENST00000585986.1_5'UTR	NM_001190821.1|NM_005904.3	NP_001177750.1|NP_005895.1	O15105	SMAD7_HUMAN	SMAD family member 7	344	MH2.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	10	Colorectal(1;0.0518)					CCAGTGTGGCGGACTTGATGA	0.582000													13	29					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182497	100182497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100182497G>A	ENST00000554176.1	+	4	1075	c.409G>A	c.(409-411)Gag>Aag	p.E137K	CYP46A1_ENST00000261835.3_Missense_Mutation_p.E290K|CYP46A1_ENST00000423126.2_Missense_Mutation_p.E193K			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	290					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCAGGACGACGAGGGTCTGCT	0.522000													21	89					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272723	81272723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81272723G>A	ENST00000520547.2	+	1	367	c.318G>A	c.(316-318)ggG>ggA	p.G106G		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	106					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			AGGACAGCGGGGAGGTACCAG	0.532000													9	99					0	0	1	0	0
C1orf192	257177	broad.mit.edu	37	1	161334873	161334873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161334873C>T	ENST00000367974.1	-	5	421	c.416G>A	c.(415-417)cGa>cAa	p.R139Q		NM_001013625.2	NP_001013647.2	Q5VTH2	CA192_HUMAN	chromosome 1 open reading frame 192	139										endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10	all_cancers(52;4.64e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GGTTGGACTTCGTGCTTGTTG	0.488000													32	87					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50750524	50750524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50750524G>A	ENST00000300589.2	+	5	2594	c.2489G>A	c.(2488-2490)cGa>cAa	p.R830Q		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	830					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				ATCTCAGACCGAGGCATCTGC	0.428000													17	28					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055528	75055528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75055528C>T	ENST00000326665.5	-	12	2181	c.1963G>A	c.(1963-1965)Gag>Aag	p.E655K	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.E458K	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	655	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGCTTGGTCTCCACATCTGCT	0.403000													22	95					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921933	24921933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24921933C>T	ENST00000329468.2	+	1	1393	c.919C>T	c.(919-921)Cct>Tct	p.P307S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TGATGAGAAGCCTTTCTGTAT	0.587000													25	78					0	0	1	0	0
TTC12	54970	broad.mit.edu	37	11	113221964	113221964	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113221964C>T	ENST00000393020.1	+	15	1656	c.1251C>T	c.(1249-1251)ttC>ttT	p.F417F	TTC12_ENST00000478125.1_3'UTR|TTC12_ENST00000314756.3_Silent_p.F417F|TTC12_ENST00000483239.2_Silent_p.F423F|TTC12_ENST00000529221.1_Silent_p.F417F			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	417							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TCAACAGATTCCAAGTCTGGT	0.423000													14	45					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314000	54314000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54314000C>T	ENST00000324134.6	-	3	1081	c.913G>A	c.(913-915)Gat>Aat	p.D305N	NLRP12_ENST00000391772.1_Missense_Mutation_p.D305N|NLRP12_ENST00000535162.1_Missense_Mutation_p.D305N|NLRP12_ENST00000391773.1_Missense_Mutation_p.D305N|NLRP12_ENST00000354278.3_Missense_Mutation_p.D305N|NLRP12_ENST00000391775.3_Missense_Mutation_p.D305N|NLRP12_ENST00000351894.4_Missense_Mutation_p.D305N|NLRP12_ENST00000345770.5_Missense_Mutation_p.D305N	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	305	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCCTGAGGATCGTGGAAAGAA	0.582000													6	66					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531100	50531100	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50531100G>A	ENST00000374144.3	+	3	798	c.510G>A	c.(508-510)ctG>ctA	p.L170L	C10orf71_ENST00000323868.4_Silent_p.L170L			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	170										endometrium(1)	1						CTCCGGCTCTGAAAAATCCTC	0.498000													11	35					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256431	140256431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140256431C>T	ENST00000398631.2	+	1	1374	c.1374C>T	c.(1372-1374)ccC>ccT	p.P458P	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGCGCAGCCCGAGTACACAG	0.657000													31	152					0	0	1	0	0
RAB30	27314	broad.mit.edu	37	11	82693265	82693265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:82693265G>A	ENST00000533486.1	-	6	838	c.554C>T	c.(553-555)tCa>tTa	p.S185L	RAB30_ENST00000534141.1_3'UTR|RAB30_ENST00000527633.1_Missense_Mutation_p.S185L|RP11-659G9.3_ENST00000527550.1_RNA|RAB30_ENST00000260056.2_Missense_Mutation_p.S185L	NM_014488.3	NP_055303.2	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	185					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						AGGTAAGGGTGAGGATACATT	0.448000													45	93					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751506	140751506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140751506C>T	ENST00000576222.1	+	1	1676	c.1545C>T	c.(1543-1545)ttC>ttT	p.F515F	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGTGTTCGCGCAGCGAG	0.672000													14	70					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646787	57646787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57646787G>A	ENST00000269834.1	-	5	1303	c.918C>T	c.(916-918)ccC>ccT	p.P306P		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TACATTGAAAGGGTTTTTGTC	0.383000													45	149					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208940	140208940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140208940G>A	ENST00000529310.1	+	1	1378	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.E422K	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCGGCCTATGAGTTGGTGGT	0.617000													73	214					0	0	1	0	0
GPR22	2845	broad.mit.edu	37	7	107115332	107115332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107115332G>A	ENST00000304402.4	+	3	2170	c.827G>A	c.(826-828)gGt>gAt	p.G276D	COG5_ENST00000297135.3_Intron|COG5_ENST00000393603.2_Intron|COG5_ENST00000347053.3_Intron|COG5_ENST00000475638.2_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	276						integral to plasma membrane	G-protein coupled receptor activity			large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						CAAAGCAGTGGTGGGAGAAAT	0.433000													26	69					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110662232	110662232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110662232C>T	ENST00000394634.2	-	13	1776	c.1569G>A	c.(1567-1569)ggG>ggA	p.G523G	CFI_ENST00000512148.1_Silent_p.G516G|CFI_ENST00000394635.3_Silent_p.G531G	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	523	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CTCCAGAGTCCCCTTTACAGG	0.463000													86	204					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152695833	152695833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152695833G>A	ENST00000360283.6	-	13	1521	c.1264C>T	c.(1264-1266)Cta>Tta	p.L422L	CACNB4_ENST00000201943.5_Silent_p.L393L|CACNB4_ENST00000539935.1_Silent_p.L455L|CACNB4_ENST00000427385.1_Silent_p.L437L|CACNB4_ENST00000534999.1_Silent_p.L421L|CACNB4_ENST00000397327.2_Silent_p.L408L			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	455					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GAGGTCATTAGACTTCGTCTT	0.418000													46	103					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6472810	6472810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6472810C>T	ENST00000263125.5	-	17	2026	c.1927G>A	c.(1927-1929)Gaa>Aaa	p.E643K	PRKCQ_ENST00000397176.2_Missense_Mutation_p.E580K|PRKCQ_ENST00000539722.1_Missense_Mutation_p.E518K	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	643	AGC-kinase C-terminal.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TCCTTCCGTTCAAGTTCCTCC	0.602000													23	68					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41976634	41976634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:41976634C>T	ENST00000372584.1	-	8	7720	c.6706G>A	c.(6706-6708)Gag>Aag	p.E2236K	HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000247584.5_Missense_Mutation_p.E2237K|HIVEP3_ENST00000372583.1_Missense_Mutation_p.E2237K|HIVEP3_ENST00000429157.2_Missense_Mutation_p.E2236K	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	2237					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TCCTGGGCCTCCCGGGCCCCT	0.697000													14	52					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40746004	40746004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40746004C>T	ENST00000216194.7	+	2	378	c.322C>T	c.(322-324)Ctt>Ttt	p.L108F	ADSL_ENST00000342312.6_Missense_Mutation_p.L108F|ADSL_ENST00000454266.2_Missense_Mutation_p.L108F	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	108					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						CATTATTCACCTTGGTGCTAC	0.423000													21	88					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71906323	71906323	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71906323G>A	ENST00000258104.3	+	52	6181	c.5904G>A	c.(5902-5904)tgG>tgA	p.W1968*	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Nonsense_Mutation_p.W1969*|DYSF_ENST00000409744.1_Nonsense_Mutation_p.W1976*|DYSF_ENST00000410020.3_Nonsense_Mutation_p.W2007*|DYSF_ENST00000413539.2_Nonsense_Mutation_p.W1999*|DYSF_ENST00000429174.2_Nonsense_Mutation_p.W1989*|DYSF_ENST00000409366.1_Nonsense_Mutation_p.W1990*|DYSF_ENST00000409582.3_Nonsense_Mutation_p.W2006*|DYSF_ENST00000409762.1_Nonsense_Mutation_p.W1985*|DYSF_ENST00000409651.1_Nonsense_Mutation_p.W2000*|DYSF_ENST00000410041.1_Nonsense_Mutation_p.W1986*	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1968						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TGAAGGGCTGGTGGCCCTGTG	0.522000													15	48					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103444462	103444462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103444462C>T	ENST00000358392.2	-	34	3016	c.2699G>A	c.(2698-2700)cGa>cAa	p.R900Q	COL11A1_ENST00000370096.3_Missense_Mutation_p.R888Q|COL11A1_ENST00000512756.1_Missense_Mutation_p.R772Q|COL11A1_ENST00000353414.4_Missense_Mutation_p.R849Q	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	888	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCTTGAACCTCGAGGACCCTG	0.388000													24	90					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4153782	4153782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4153782G>A	ENST00000404826.2	+	25	3838	c.3699G>A	c.(3697-3699)ctG>ctA	p.L1233L	SDK1_ENST00000389531.3_Silent_p.L1233L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1233	Fibronectin type-III 6.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTGACCGGCTGGAGAGAGAAT	0.612000													12	42					0	0	1	0	0
FMR1	2332	broad.mit.edu	37	X	147026416	147026416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:147026416C>T	ENST00000218200.8	+	14	1665	c.1436C>T	c.(1435-1437)tCt>tTt	p.S479F	FMR1_ENST00000370475.4_Missense_Mutation_p.S500F|FMR1_ENST00000370470.1_Intron|FMR1_ENST00000440235.2_Missense_Mutation_p.S147F|FMR1_ENST00000439526.2_Missense_Mutation_p.S477F|FMR1_ENST00000370477.1_Intron|FMR1_ENST00000370471.3_Intron	NM_001185076.1|NM_001185082.1	NP_001172005.1|NP_001172011.1	Q06787	FMR1_HUMAN	fragile X mental retardation 1	500	Interaction with RANBP9.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			NS(1)|breast(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	35	Acute lymphoblastic leukemia(192;6.56e-05)					TCAAATGCTTCTGAAACAGAA	0.428000									Fragile X syndrome				4	23					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767500	105767500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:105767500C>T	ENST00000374798.3	+	5	657	c.587C>T	c.(586-588)tCa>tTa	p.S196L	CYLC2_ENST00000487798.1_Missense_Mutation_p.S196L	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	196	3 X approximate tandem repeats.|31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				aaaaaggaTTCAAACAAAGGC	0.373000													6	30					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96059665	96059665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:96059665C>T	ENST00000343702.4	-	9	2119	c.1671G>A	c.(1669-1671)ctG>ctA	p.L557L	NTN4_ENST00000538383.1_Silent_p.L520L|PGAM1P5_ENST00000552554.1_RNA|NTN4_ENST00000553059.1_Silent_p.L534L|NTN4_ENST00000344911.4_Silent_p.L520L	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	557	NTR.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						GGAAAATCTTCAGTTTGGTAG	0.363000													19	70					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24669185	24669185	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24669185G>A	ENST00000361548.4	+	10	1438	c.1206_splice	c.e10-1	p.G403_splice	GRHL3_ENST00000350501.5_Splice_Site_p.G403_splice|GRHL3_ENST00000356046.2_Splice_Site_p.G357_splice|GRHL3_ENST00000342072.4_Splice_Site_p.G310_splice|GRHL3_ENST00000236255.4_Splice_Site_p.G408_splice	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	403					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CCCCTGCAGGGAGCTGAGAGG	0.587000													39	112					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76503739	76503739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76503739G>A	ENST00000389840.5	-	28	4497	c.4373C>T	c.(4372-4374)tCc>tTc	p.S1458F	DNAH17_ENST00000585328.1_Missense_Mutation_p.S1459F					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGGTACTTGGACATCATCAG	0.607000													5	34					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220333389	220333389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220333389G>A	ENST00000312358.7	+	11	3364	c.3232G>A	c.(3232-3234)Ggc>Agc	p.G1078S	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1078	Ig-like 5.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GGTGTTGGAGGGCCGAGCTGC	0.637000													31	53					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149502526	149502526	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149502526C>T	ENST00000378016.2	+	0	8339							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCTGGACTTCCTGGTCCTCC	0.667000													27	42					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	31086160	31086160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:31086160C>T	ENST00000597505.1	-	18	2446	c.2447G>A	c.(2446-2448)aGt>aAt	p.S816N	DCDC1_ENST00000437348.1_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GTTGCTGGCACTTTCTTGCAG	0.413000													33	36					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123264747	123264747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123264747C>T	ENST00000451558.1	+	10	1097	c.576C>T	c.(574-576)atC>atT	p.I192I	RP11-390E23.3_ENST00000429396.1_RNA|RP11-390E23.3_ENST00000418409.1_RNA|RP11-390E23.3_ENST00000440504.1_RNA|ASB15_ENST00000540573.1_Silent_p.I192I|ASB15_ENST00000451215.1_Silent_p.I192I|ASB15_ENST00000275699.3_Silent_p.I192I|ASB15_ENST00000434204.1_Silent_p.I192I			Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box containing 15	192					intracellular signal transduction					breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(3)	12						GAAAAGATATCGTAGCTCTGC	0.517000											OREG0018282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	84					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53165672	53165672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53165672C>T	ENST00000332411.2	-	6	1299	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	416	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTGACATTTTCAATCTCAGCC	0.552000													15	173					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21217225	21217225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21217225G>A	ENST00000380216.1	-	1	85	c.80C>T	c.(79-81)cCt>cTt	p.P27L		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	27					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GTGAGTCTGAGGCAGATCACA	0.488000													30	113					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150886928	150886928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150886928C>T	ENST00000261800.5	-	22	12316	c.12304G>A	c.(12304-12306)Gag>Aag	p.E4102K		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	4102					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGTTGAGCTCGATGGCAGGC	0.567000													20	89					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100131594	100131594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100131594C>T	ENST00000394897.1	-	4	410	c.328G>A	c.(328-330)Ggc>Agc	p.G110S	ADH6_ENST00000394899.2_Missense_Mutation_p.G110S|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000237653.7_Missense_Mutation_p.G110S|ADH6_ENST00000407820.2_5'UTR|RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	110					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	CAAAAATTGCCCTCAGAATTC	0.303000													32	91					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28499611	28499611	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28499611C>T	ENST00000412168.2	+	3	387	c.298C>T	c.(298-300)Ccc>Tcc	p.P100S	GPX5_ENST00000442674.2_3'UTR|GPX5_ENST00000469384.1_Intron	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	100					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	GTTGGGCTTTCCCTGCAACCA	0.468000													63	227					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55145099	55145099	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55145099G>A	ENST00000414150.2	+	12	2491	c.2213G>A	c.(2212-2214)aGg>aAg	p.R738K	MROH7_ENST00000339553.5_Missense_Mutation_p.R738K|MROH7_ENST00000545244.1_Missense_Mutation_p.R306K|MROH7_ENST00000454855.2_Missense_Mutation_p.R256K|MROH7_ENST00000421030.2_Missense_Mutation_p.R738K|MROH7_ENST00000409996.1_Missense_Mutation_p.R306K|MROH7_ENST00000395690.2_Missense_Mutation_p.R738K					maestro heat-like repeat family member 7																		TACCGCCACAGGGCGCTGGAG	0.657000													11	40					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16060099	16060099	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16060099C>T	ENST00000322107.1	+	1	282	c.282C>T	c.(280-282)acC>acT	p.T94T		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						ATTCCATCACCTTTGTGGCTT	0.512000													97	304					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149075934	149075934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:149075934G>A	ENST00000355292.3	-	5	2507	c.2145C>T	c.(2143-2145)atC>atT	p.I715I	NR3C2_ENST00000512865.1_Intron|NR3C2_ENST00000344721.4_Silent_p.I711I|NR3C2_ENST00000511528.1_Silent_p.I715I|RP11-76G10.1_ENST00000514843.1_RNA|NR3C2_ENST00000503313.1_5'UTR|NR3C2_ENST00000358102.3_Silent_p.I711I|NR3C2_ENST00000342437.4_Intron			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	711	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TTGCAGGAGCGATGTACGTTG	0.577000													45	102					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77283313	77283313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77283313C>T	ENST00000388914.3	-	12	2138	c.1986G>A	c.(1984-1986)gtG>gtA	p.V662V		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	662										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						TACTTGTTTTCACCTCATTTA	0.418000													33	90					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61848064	61848064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61848064C>T	ENST00000280772.1	-	29	3572	c.3381G>A	c.(3379-3381)acG>acA	p.T1127T	ANK3_ENST00000503366.1_Silent_p.T1128T|ANK3_ENST00000373827.2_Silent_p.T1121T|ANK3_ENST00000355288.2_Silent_p.T261T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1127					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGAAATCTTTCGTGATAATCC	0.438000													29	98					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81654598	81654598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81654598G>A	ENST00000558726.1	-	4	492	c.357C>T	c.(355-357)atC>atT	p.I119I	TMC3_ENST00000359440.5_Silent_p.I119I			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	119						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						AGGGAATGAAGATGACCACAA	0.483000													14	18					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139940249	139940249	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139940249G>A	ENST00000357560.4	-	11	1450	c.1007C>T	c.(1006-1008)tCt>tTt	p.S336F	APBB3_ENST00000412920.3_Missense_Mutation_p.S334F|APBB3_ENST00000508496.2_Missense_Mutation_p.S113F|APBB3_ENST00000358580.5_Intron|APBB3_ENST00000354402.5_Missense_Mutation_p.S343F|APBB3_ENST00000511201.2_Intron|APBB3_ENST00000356738.2_Missense_Mutation_p.S341F	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	336	PID 2.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCATGAGAGAGTCAGACAC	0.607000													11	42					0	0	1	0	0
RBBP5	5929	broad.mit.edu	37	1	205068928	205068928	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205068928G>A	ENST00000264515.6	-	9	1060	c.919C>T	c.(919-921)Cga>Tga	p.R307*	RBBP5_ENST00000367164.1_Nonsense_Mutation_p.R307*	NM_001193273.1|NM_005057.3	NP_001180202.1|NP_005048.2	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	307					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			ATGATGGGTCGAACAGGATGC	0.363000													50	135					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70049347	70049347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70049347C>T	ENST00000370598.1	+	26	4231	c.3410C>T	c.(3409-3411)tCa>tTa	p.S1137L	BAI3_ENST00000546190.1_Missense_Mutation_p.S101L|BAI3_ENST00000238918.8_Missense_Mutation_p.S343L	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1137					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GTGTTTGATTCATTGCAAGGC	0.443000													69	118					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54971065	54971065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54971065C>T	ENST00000243052.3	+	15	2000	c.1564C>T	c.(1564-1566)Cca>Tca	p.P522S	PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Missense_Mutation_p.P481S|PPP1R1A_ENST00000547431.1_3'UTR|PDE1B_ENST00000550620.1_Missense_Mutation_p.P502S	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	522					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						AGAGGCCCCCCCATCCCCTGC	0.567000													63	128					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44044528	44044528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44044528G>A	ENST00000359947.4	+	7	956	c.616G>A	c.(616-618)Gag>Aag	p.E206K	PTPRF_ENST00000438120.1_Missense_Mutation_p.E206K|PTPRF_ENST00000372414.3_Missense_Mutation_p.E206K|PTPRF_ENST00000372413.3_Missense_Mutation_p.E206K	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	206	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGCAAGTACGAGTGTGTGGC	0.602000													14	51					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166944732	166944732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:166944732C>T	ENST00000510118.1	-	5	701	c.361G>A	c.(361-363)Gcc>Acc	p.A121T	RPS6KA2_ENST00000366863.2_5'UTR|RPS6KA2_ENST00000481261.2_Missense_Mutation_p.A7T|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.A96T|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.A104T|RPS6KA2_ENST00000405189.3_Missense_Mutation_p.A7T			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	96	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TTTAGGGTGGCTTTCTTAAGG	0.478000													37	93					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804617	115804617	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115804617C>T	ENST00000369295.2	+	1	812	c.726C>T	c.(724-726)ttC>ttT	p.F242F		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	242					positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	TCATGGCCTTCGTGTACCTGC	0.657000													5	51					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77619947	77619947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77619947C>T	ENST00000521891.2	+	3	3205	c.2757C>T	c.(2755-2757)gcC>gcT	p.A919A	ZFHX4_ENST00000050961.6_Silent_p.A893A|ZFHX4_ENST00000455469.2_Silent_p.A893A|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Silent_p.A893A	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	893						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTGGAGGCCCTAAGTGTGC	0.507000										HNSCC(33;0.089)			6	40					0	0	1	0	0
PTCD1	26024	broad.mit.edu	37	7	99021527	99021527	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99021527G>A	ENST00000292478.4	-	7	2041	c.1791C>T	c.(1789-1791)gcC>gcT	p.A597A	ATP5J2-PTCD1_ENST00000413834.1_Silent_p.A646A|PTCD1_ENST00000555673.1_Silent_p.A646A	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1									p.A597A(1)		endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GCTTCCTGATGGCCGCGTTGA	0.527000													6	80					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159654305	159654305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159654305C>T	ENST00000297267.9	+	11	2961	c.2761C>T	c.(2761-2763)Cgg>Tgg	p.R921W	FNDC1_ENST00000340366.6_Missense_Mutation_p.R858W	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	921						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CAGCCTGCATCGGAAGGAACC	0.602000													8	28					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703277	4703277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4703277C>T	ENST00000396950.3	-	2	904	c.665G>A	c.(664-666)cGa>cAa	p.R222Q		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAGAACCGTTCGTATTATCAG	0.488000													29	59					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56300731	56300731	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56300731G>A	ENST00000443188.1	-	10	3258	c.2548C>T	c.(2548-2550)Caa>Taa	p.Q850*	NLRP11_ENST00000589824.2_Nonsense_Mutation_p.Q796*|NLRP11_ENST00000592953.1_Nonsense_Mutation_p.Q751*|NLRP11_ENST00000589093.1_Nonsense_Mutation_p.Q850*|NLRP11_ENST00000360133.3_Nonsense_Mutation_p.Q796*	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	850							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GCAATATATTGACAGATATCG	0.418000													38	143					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561350	9561350	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9561350T>A	ENST00000378429.3	-	5	978	c.432A>T	c.(430-432)gaA>gaT	p.E144D	PAK7_ENST00000378423.1_Missense_Mutation_p.E144D|PAK7_ENST00000353224.5_Missense_Mutation_p.E144D	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	144	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CCCTGTACTTTTCGGTCGTGT	0.512000													80	153					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21419872	21419872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21419872G>A	ENST00000313654.9	+	27	3556	c.3315G>A	c.(3313-3315)ggG>ggA	p.G1105G	LAMA3_ENST00000399516.3_Silent_p.G1105G	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1105	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCTTCCTGGGGTCACCTTGA	0.488000													29	68					0	0	1	0	0
QPRT	23475	broad.mit.edu	37	16	29706093	29706093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29706093C>T	ENST00000395384.4	+	2	283	c.122C>T	c.(121-123)cCc>cTc	p.P41L	QPRT_ENST00000562473.1_Intron|QPRT_ENST00000219771.7_Intron|AC009133.19_ENST00000449759.1_Missense_Mutation_p.80_80insS	NM_014298.3	NP_055113.2	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	41					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9					Niacin(DB00627)	GGGGCAGGCCCCTCGCAGGCG	0.652000													19	73					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44986361	44986361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44986361G>A	ENST00000372227.1	-	3	712	c.172C>T	c.(172-174)Ctc>Ttc	p.L58F	SLC35C2_ENST00000243896.2_Missense_Mutation_p.L58F|SLC35C2_ENST00000372230.5_Missense_Mutation_p.L58F|SLC35C2_ENST00000372229.1_Intron|SLC35C2_ENST00000317734.8_Missense_Mutation_p.L58F|SLC35C2_ENST00000543605.1_Missense_Mutation_p.L87F			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	58					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				GCGGAGAAGAGGAAGATCACG	0.617000													18	58					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87373167	87373167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87373167C>T	ENST00000327946.7	-	15	2683	c.2598G>A	c.(2596-2598)aaG>aaA	p.K866K	GRID1_ENST00000536331.1_Silent_p.K437K	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	866						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TGCTGACCTCCTTGGGGGTCT	0.612000										Multiple Myeloma(13;0.14)			9	23					0	0	1	0	0
TRBV19	28568	broad.mit.edu	37	7	142326879	142326879	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142326879G>A	ENST00000390393.3	+	0	385																											AGGACCCAGGGCAAGGGCTGA	0.473000													44	136					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155161724	155161724	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155161724C>T	ENST00000357232.3	-	23	5958	c.5959G>A	c.(5959-5961)Gat>Aat	p.D1987N		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1987	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGTGGATTATCATTGACATCC	0.393000													20	45					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50719833	50719833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50719833G>A	ENST00000449103.1	-	22	3758	c.3618C>T	c.(3616-3618)atC>atT	p.I1206I	PLXNB2_ENST00000359337.4_Silent_p.I1206I			O15031	PLXB2_HUMAN	plexin B2	1206					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCATGGGCACGATGACCAGCG	0.677000													6	19					0	0	1	0	0
DOLK	22845	broad.mit.edu	37	9	131708608	131708608	+	Silent	SNP	G	G	A	rs149462670		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131708608G>A	ENST00000372586.3	-	1	1290	c.975C>T	c.(973-975)tcC>tcT	p.S325S	RP11-101E3.5_ENST00000482796.1_Intron	NM_014908.3	NP_055723.1	Q9UPQ8	DOLK_HUMAN	dolichol kinase	325					dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity			breast(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	11						TCTTGGACTCGGAAGATGACC	0.572000													66	150					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134617989	134617989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:134617989C>T	ENST00000361388.2	+	5	935	c.469C>T	c.(469-471)Caa>Taa	p.Q157*	CALD1_ENST00000417172.1_Nonsense_Mutation_p.Q157*|CALD1_ENST00000495522.1_Nonsense_Mutation_p.Q151*|CALD1_ENST00000361901.2_Nonsense_Mutation_p.Q157*|CALD1_ENST00000361675.2_Nonsense_Mutation_p.Q157*|CALD1_ENST00000393118.2_Nonsense_Mutation_p.Q151*|CALD1_ENST00000422748.1_Nonsense_Mutation_p.Q157*|CALD1_ENST00000543443.1_Nonsense_Mutation_p.Q162*|CALD1_ENST00000424922.1_Nonsense_Mutation_p.Q151*	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	370	Myosin and calmodulin-binding (By similarity).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						TGAAAGTCGCCAAGAAAGATA	0.403000													9	20					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847869	123847869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123847869G>A	ENST00000531945.1	-	1	619	c.530C>T	c.(529-531)aCc>aTc	p.T177I		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CAGGCGGAAGGTGAGGGAGGT	0.557000													8	67					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41450887	41450887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41450887C>T	ENST00000400454.1	-	26	4915	c.4438G>A	c.(4438-4440)Gag>Aag	p.E1480K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1480	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGCTCCTGCTCCTTTGAGAAC	0.572000													6	29					0	0	1	0	0
GP6	51206	broad.mit.edu	37	19	55525594	55525594	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55525594C>T	ENST00000310373.3	-	8	1746	c.1719G>A	c.(1717-1719)agG>agA	p.R573R	GP6_ENST00000333884.2_3'UTR|CTC-550B14.7_ENST00000586845.1_RNA|CTC-550B14.7_ENST00000593060.1_RNA|GP6_ENST00000417454.1_3'UTR	NM_001083899.1	NP_001077368.1	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	0					enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		acctcagccccctgagttgct	0.522000													4	12					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41476499	41476499	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41476499G>A	ENST00000314992.5	-	10	1365	c.1175C>T	c.(1174-1176)cCt>cTt	p.P392L	EXD1_ENST00000458580.2_Missense_Mutation_p.P450L	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	392					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						TAGATGTTGAGGATTTGTAGC	0.393000													19	205					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130162359	130162359	+	Missense_Mutation	SNP	C	C	T	rs150604117	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130162359C>T	ENST00000265379.6	+	36	7021	c.6527C>T	c.(6526-6528)gCc>gTc	p.A2176V	COL6A5_ENST00000432398.2_Missense_Mutation_p.A2176V			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2176	Nonhelical region.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						CTTGAGGATGCCTGTAGACTC	0.368000													18	55					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092811	151092811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151092811G>A	ENST00000370335.1	+	3	942	c.675G>A	c.(673-675)gaG>gaA	p.E225E	MAGEA4_ENST00000276344.2_Silent_p.E225E|MAGEA4_ENST00000393921.1_Silent_p.E225E|MAGEA4_ENST00000370340.3_Silent_p.E225E|MAGEA4_ENST00000370337.4_Silent_p.E225E|MAGEA4_ENST00000360243.2_Silent_p.E225E|MAGEA4_ENST00000393920.1_Silent_p.E225E			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	225	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCTGGGAGGAGCTGGGTGTGA	0.537000													56	53					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141408672	141408672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141408672C>T	ENST00000397541.2	+	1	520	c.114C>T	c.(112-114)agC>agT	p.S38S	WEE2-AS1_ENST00000488785.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	38					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					AGGCTTCGAGCCAAACCCCAG	0.468000													58	198					0	0	1	0	0
RNPS1	10921	broad.mit.edu	37	16	2304009	2304009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2304009G>A	ENST00000565678.1	-	8	1419	c.874C>T	c.(874-876)Cgc>Tgc	p.R292C	AC009065.1_ENST00000454671.1_Missense_Mutation_p.R91Q|RNPS1_ENST00000567147.1_Silent_p.A221A|RNPS1_ENST00000568631.1_Missense_Mutation_p.R292C|RNPS1_ENST00000566458.1_Missense_Mutation_p.R269C|RNPS1_ENST00000320225.5_Missense_Mutation_p.R292C|RNPS1_ENST00000397086.2_Missense_Mutation_p.R292C|RNPS1_ENST00000569598.2_Missense_Mutation_p.R198C|RNPS1_ENST00000301730.8_Missense_Mutation_p.R292C|RNPS1_ENST00000566397.1_Missense_Mutation_p.R115C|RNPS1_ENST00000561718.1_Missense_Mutation_p.R115C			Q15287	RNPS1_HUMAN	RNA binding protein S1, serine-rich domain	292	Arg/Pro-rich.|Necessary for interaction with TRA2B, nuclear localization and exon-skipping.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|urinary_tract(1)	9						TGGCGGCGGCGGCCCGGGGAC	0.647000													2	1					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77662359	77662359	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77662359G>A	ENST00000296043.6	+	5	3986	c.3033G>A	c.(3031-3033)ctG>ctA	p.L1011L		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1011	ASD1.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GCCGGCGCCTGACTCCCGAGC	0.726000													6	16					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188202397	188202397	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:188202397C>T	ENST00000312675.4	+	4	457	c.211C>T	c.(211-213)Cca>Tca	p.P71S	LPP_ENST00000543006.1_Missense_Mutation_p.P71S|LPP_ENST00000448637.1_Missense_Mutation_p.P71S	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	71	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TCTTCCACCCCCACCTCCACC	0.413000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								51	157					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51960961	51960961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51960961C>T	ENST00000321424.3	-	2	553	c.487G>A	c.(487-489)Ggg>Agg	p.G163R	SIGLEC8_ENST00000430817.1_Intron|SIGLEC8_ENST00000340550.5_Intron	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	163	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TCTAGGGTCCCTAGGATGAGG	0.602000													29	71					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14339441	14339441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:14339441C>T	ENST00000571589.1	+	11	1308	c.1136C>T	c.(1135-1137)cCt>cTt	p.P379L	MKL2_ENST00000574045.1_Missense_Mutation_p.P379L|MKL2_ENST00000341243.5_Missense_Mutation_p.P368L|MKL2_ENST00000318282.5_Missense_Mutation_p.P379L	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	368					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AATGCCACACCTAACACACCA	0.378000													30	118					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110740790	110740790	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110740790C>T	ENST00000331565.4	+	12	2393	c.1908C>T	c.(1906-1908)ttC>ttT	p.F636F		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	636					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CTGTGGTGTTCGTCCTGCGGC	0.607000													12	30					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132160519	132160519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:132160519C>T	ENST00000511190.1	-	6	2199	c.1730G>A	c.(1729-1731)cGa>cAa	p.R577Q	USP26_ENST00000406273.1_Missense_Mutation_p.R577Q|USP26_ENST00000370832.1_Missense_Mutation_p.R577Q	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	577					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					AGTCATCTTTCGAATAACTTT	0.398000													38	22					0	0	1	0	0
HRASLS2	54979	broad.mit.edu	37	11	63325900	63325900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63325900C>T	ENST00000255695.1	-	3	409	c.351G>A	c.(349-351)gtG>gtA	p.V117V		NM_017878.1	NP_060348.1	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	117					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6						GCAGATGGTTCACGAAGTGCT	0.597000													23	61					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149477052	149477052	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149477052C>T	ENST00000378016.2	+	0	1229							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGCAGGTTTCCCCTGCTGAG	0.582000													11	8					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587558	55587558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55587558C>T	ENST00000333976.4	+	1	473	c.453C>T	c.(451-453)gcC>gcT	p.A151A		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				GATCCTATGCCTGGGGAGTCT	0.478000													25	165					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233925273	233925273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233925273C>T	ENST00000359570.5	+	1	85	c.85C>T	c.(85-87)Ctc>Ttc	p.L29F	INPP5D_ENST00000538935.1_Missense_Mutation_p.L29F			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	29	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CGGGAGCTTCCTCGTGCGTGC	0.642000													12	32					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62041900	62041900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62041900C>T	ENST00000578147.1	-	9	1456	c.1380G>A	c.(1378-1380)gaG>gaA	p.E460E	SCN4A_ENST00000435607.1_Silent_p.E460E			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	460					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TCTCCTTATCCTCGGCCAGGG	0.532000													13	41					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151773863	151773863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:151773863G>A	ENST00000535741.1	-	23	3472	c.2999C>T	c.(2998-3000)tCa>tTa	p.S1000L	LRBA_ENST00000510413.1_Missense_Mutation_p.S1000L|LRBA_ENST00000357115.3_Missense_Mutation_p.S1000L|LRBA_ENST00000507224.1_Missense_Mutation_p.S1000L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1000						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AGATTCTAGTGAACTTGTCTT	0.378000													22	76					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43625229	43625229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:43625229G>A	ENST00000332857.6	-	4	3486	c.3458C>T	c.(3457-3459)cCt>cTt	p.P1153L		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		TACTGAAGGAGGCTGTTTCTT	0.453000													13	114					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148916196	148916196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:148916196C>T	ENST00000264613.6	-	9	1933	c.1671G>A	c.(1669-1671)atG>atA	p.M557I	CP_ENST00000462336.1_5'UTR	NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	557	F5/8 type A 2.|Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TGCATATTTTCATTGGCCCAA	0.378000													31	77					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152329710	152329710	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152329710G>A	ENST00000388718.5	-	3	624	c.552C>T	c.(550-552)tcC>tcT	p.S184S	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	184	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCACAGCTGGACCTGTGGT	0.468000													68	154					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086942	100086942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100086942C>T	ENST00000423930.1	+	4	1757	c.1598C>T	c.(1597-1599)tCc>tTc	p.S533F	NYAP1_ENST00000300179.2_Missense_Mutation_p.S533F|NYAP1_ENST00000454988.1_Missense_Mutation_p.S476F			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	533																	TGCCTGGCCTCCCCCCACAGC	0.697000													8	8					0	0	1	0	0
ACR	49	broad.mit.edu	37	22	51177731	51177731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:51177731C>T	ENST00000216139.5	+	2	150	c.110C>T	c.(109-111)cCa>cTa	p.P37L	ACR_ENST00000529621.1_Missense_Mutation_p.P37L	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	37					acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		AGGCAAAACCCACAGGGTGGT	0.597000													4	17					0	0	1	0	0
PSMG2	56984	broad.mit.edu	37	18	12706668	12706668	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:12706668T>G	ENST00000317615.6	+	2	859	c.177T>G	c.(175-177)aaT>aaG	p.N59K	PSMG2_ENST00000590217.1_Missense_Mutation_p.N59K|RP11-973H7.2_ENST00000585331.1_RNA	NM_020232.4|NM_147163.1	NP_064617.2|NP_671692.1	Q969U7	PSMG2_HUMAN	proteasome (prosome, macropain) assembly chaperone 2	59					proteasome assembly	nucleus	protein binding			lung(1)|prostate(2)|skin(1)	4						TTGGAAACAATCCATATGCGA	0.368000													14	98					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5758568	5758568	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5758568G>A	ENST00000317121.3	+	1	888	c.822G>A	c.(820-822)gaG>gaA	p.E274E	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	274					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		ATCTGACAGAGATGAAGGCTA	0.433000													83	348					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120241121	120241121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120241121G>A	ENST00000392521.2	-	10	1239	c.1184C>T	c.(1183-1185)tCg>tTg	p.S395L	CIT_ENST00000261833.7_Missense_Mutation_p.S395L	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	395	AGC-kinase C-terminal.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGAAACCCACGAATTCTTCTC	0.522000													42	98					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51165482	51165482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51165482G>A	ENST00000293441.1	-	23	6244	c.6226C>T	c.(6226-6228)Ctc>Ttc	p.L2076F	SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000391813.1_Missense_Mutation_p.L1463F|SHANK1_ENST00000359082.3_Missense_Mutation_p.L2067F|SHANK1_ENST00000391814.1_Missense_Mutation_p.L2084F	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2076					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GTCGGTGAGAGGGAGCGCGAG	0.682000													6	42					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82578963	82578963	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82578963G>A	ENST00000423517.2	-	6	11278	c.10941C>T	c.(10939-10941)ctC>ctT	p.L3647L	PCLO_ENST00000333891.8_Silent_p.L3647L|PCLO_ENST00000437081.1_Silent_p.L367L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3578					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TATCATCAGGGAGGGGTTTTT	0.473000													59	182					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3228264	3228264	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3228264G>A	ENST00000217939.6	-	7	8134	c.7980C>T	c.(7978-7980)acC>acT	p.T2660T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2660	Ig-like C2-type 11.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCCCGGGAGGGGTGCAGGGGA	0.592000													38	31					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744773	140744773	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140744773C>T	ENST00000518069.1	+	1	876	c.876C>T	c.(874-876)ttC>ttT	p.F292F	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGAGACTTTCCAACTTGATT	0.463000													12	36					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193002904	193002904	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:193002904C>T	ENST00000342358.4	-	27	3142	c.3023_splice	c.e27-1	p.E1009_splice	ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1009					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AGAAAACACTCACTACAAAAG	0.318000													15	54					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73721613	73721613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:73721613G>A	ENST00000427855.1	+	14	1616	c.1514G>A	c.(1513-1515)cGg>cAg	p.R505Q	PAPLN_ENST00000554301.1_Missense_Mutation_p.R505Q|PAPLN_ENST00000381166.3_Missense_Mutation_p.R505Q|PAPLN_ENST00000340738.5_Missense_Mutation_p.R478Q|PAPLN_ENST00000555445.1_Missense_Mutation_p.R505Q			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	505	TSP type-1 5.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding	p.R478Q(1)|p.R505Q(1)		NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		TCGGGCACTCGGAGGCGACAG	0.657000													11	46					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11060364	11060364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11060364C>T	ENST00000287766.4	+	5	872	c.451C>T	c.(451-453)Ctg>Ttg	p.L151L	SLC6A1_ENST00000536032.1_5'UTR|SLC6A1-AS1_ENST00000414969.2_RNA	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	151					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CATTTACTACCTGTACAACTC	0.582000													13	36					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242383365	242383365	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:242383365C>T	ENST00000442594.2	-	6	893	c.384G>A	c.(382-384)caG>caA	p.Q128Q	PLD5_ENST00000536534.1_Silent_p.Q220Q|PLD5_ENST00000427495.1_Silent_p.Q158Q	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	220						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AGAAGGAGGACTGCAGCCGGC	0.547000													16	55					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100155362	100155362	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100155362C>T	ENST00000263174.4	+	7	1921	c.1546C>T	c.(1546-1548)Cct>Tct	p.P516S	PALMD_ENST00000605497.1_Missense_Mutation_p.P516S	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	516					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		CTTAGGCAGCCCTGTCCACCA	0.428000													25	68					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16033188	16033188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16033188G>A	ENST00000326742.7	-	7	972	c.971C>T	c.(970-972)aCc>aTc	p.T324I	CYP4F11_ENST00000402119.3_Missense_Mutation_p.T324I|CYP4F11_ENST00000248041.7_Missense_Mutation_p.T324I			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	324					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						AAACATGAAGGTGTCAGCTTC	0.527000													59	163					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753258	76753258	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76753258C>T	ENST00000536229.3	+	1	1577	c.868C>T	c.(868-870)Cgc>Tgc	p.R290C	SALL3_ENST00000537592.2_Missense_Mutation_p.R423C|SALL3_ENST00000575389.2_Missense_Mutation_p.R423C			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCACAAATGCCGCTTCTGCGC	0.642000													8	15					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50658827	50658827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50658827G>A	ENST00000439308.2	-	16	4453	c.3961C>T	c.(3961-3963)Ctg>Ttg	p.L1321L	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Silent_p.L1321L	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1321					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCTACAGGCAGCCGTGGCCCA	0.682000													11	33					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649546	75649546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:75649546C>T	ENST00000361470.2	+	1	1501	c.1223C>T	c.(1222-1224)cCt>cTt	p.P408L		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	408	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CTGCCTAACCCTGGTGAGGGC	0.627000													4	16					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78056580	78056580	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:78056580G>A	ENST00000299642.4	+	1	169	c.84G>A	c.(82-84)caG>caA	p.Q28Q	CLEC3A_ENST00000575655.1_Silent_p.Q19Q|RP11-281J9.2_ENST00000563114.1_RNA	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	19					skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						TCCTGGACCAGACCACCAGCC	0.507000													5	56					0	0	1	0	0
SFXN2	118980	broad.mit.edu	37	10	104488271	104488271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104488271C>T	ENST00000369893.4	+	4	583	c.416C>T	c.(415-417)tCc>tTc	p.S139F		NM_178858.4	NP_849189.1	Q96NB2	SFXN2_HUMAN	sideroflexin 2	139					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|prostate(1)	13		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		AATGCGGCTTCCCCCACATCA	0.567000													37	72					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27448833	27448833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27448833G>A	ENST00000337929.3	+	4	650	c.177G>A	c.(175-177)aaG>aaA	p.K59K	IL21R_ENST00000395754.4_Silent_p.K59K|IL21R_ENST00000564089.1_Silent_p.K59K|IL21R_ENST00000395755.1_Silent_p.K59K	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	59					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						AAGAGCTGAAGGACGAGGCCA	0.612000			T	BCL6	NHL								20	55					0	0	1	0	0
NSUN7	79730	broad.mit.edu	37	4	40778245	40778245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40778245G>A	ENST00000381782.2	+	7	1500	c.1005G>A	c.(1003-1005)ttG>ttA	p.L335L	NSUN7_ENST00000316607.5_Silent_p.L335L	NM_024677.4	NP_078953.3			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						ATCCTGACTTGAAGACCCTTT	0.308000													28	92					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117188502	117188502	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117188502C>T	ENST00000362057.3	-	4	1323	c.1155G>A	c.(1153-1155)gcG>gcA	p.A385A	DFNB31_ENST00000265134.6_Silent_p.A2A	NM_001173425.1|NM_015404.3	NP_001166896.1|NP_056219.3	Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	385					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTGCCGAGTTCGCCATGGTCT	0.632000													15	22					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6058963	6058963	+	Missense_Mutation	SNP	G	G	A	rs62643643		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6058963G>A	ENST00000261405.5	-	51	8496	c.8242C>T	c.(8242-8244)Cac>Tac	p.H2748Y		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2748	CTCK.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding	p.H2748N(1)		NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TGGCAGTAGTGGATATCCACC	0.522000													25	90					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205197795	205197795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205197795C>T	ENST00000358024.3	+	1	492	c.103C>T	c.(103-105)Cct>Tct	p.P35S		NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	35						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGACCTCCGGCCTGGGGAGAC	0.677000													17	27					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35829246	35829246	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35829246C>T	ENST00000085219.5	+	6	1227	c.1161C>T	c.(1159-1161)ctC>ctT	p.L387L	CD22_ENST00000419549.2_Silent_p.L215L|CD22_ENST00000341773.6_Intron|CD22_ENST00000536635.2_Intron|CD22_ENST00000270311.6_Silent_p.L267L|CD22_ENST00000544992.2_Silent_p.L387L|CD22_ENST00000594250.1_Intron	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	387	Ig-like C2-type 3.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CAAAGATCCTCCCCTGGCACG	0.527000													29	80					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124594553	124594553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124594553C>T	ENST00000368904.1	-	9	2000	c.1051G>A	c.(1051-1053)Gaa>Aaa	p.E351K	CUZD1_ENST00000545804.1_Missense_Mutation_p.E351K|CUZD1_ENST00000392790.1_Missense_Mutation_p.E351K			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	351	ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GTGATCACTTCAGAAGTTGAG	0.338000													30	74					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32505269	32505269	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:32505269C>T	ENST00000520502.2	+	1	33	c.33C>T	c.(31-33)gtC>gtT	p.V11V	NRG1_ENST00000287840.5_Intron|NRG1_ENST00000287842.3_Intron|NRG1_ENST00000523079.1_Intron|NRG1_ENST00000341377.5_Intron|NRG1_ENST00000338921.4_Intron|NRG1_ENST00000287845.5_Intron|NRG1_ENST00000521670.1_Intron|NRG1_ENST00000405005.2_Intron|NRG1_ENST00000519301.1_Intron|NRG1_ENST00000520407.1_Intron|NRG1_ENST00000356819.4_Intron	NM_013959.3	NP_039253.1	Q02297	NRG1_HUMAN	neuregulin 1	0					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGTCTGAGGTCGCCGCCGAGA	0.612000													8	57					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74630995	74630995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74630995G>A	ENST00000358632.4	-	8	1572	c.877C>T	c.(877-879)Cgg>Tgg	p.R293W	CYP11A1_ENST00000268053.6_Missense_Mutation_p.R451W|CYP11A1_ENST00000419019.2_Missense_Mutation_p.R293W	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	451					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CCCAAGTTCCGGAAGTAGGTG	0.557000													85	102					0	0	1	0	0
F11R	50848	broad.mit.edu	37	1	160970835	160970835	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160970835G>A	ENST00000368026.6	-	3	490	c.216C>T	c.(214-216)ctC>ctT	p.L72L	F11R_ENST00000537746.1_Silent_p.L72L|F11R_ENST00000472573.1_5'UTR|F11R_ENST00000289779.3_3'UTR	NM_016946.4	NP_058642.1	Q9Y624	JAM1_HUMAN	F11 receptor	72	Ig-like V-type 1.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)	12	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			TATAGCAAACGAGTCTGGTGG	0.493000													22	41					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215820886	215820886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215820886G>A	ENST00000366943.2	-	67	15155	c.14769C>T	c.(14767-14769)atC>atT	p.I4923I	USH2A_ENST00000307340.3_Silent_p.I4923I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4923	Fibronectin type-III 34.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTGAAACTGATCCACTCGG	0.532000										HNSCC(13;0.011)			24	42					0	0	1	0	0
MVD	4597	broad.mit.edu	37	16	88723893	88723893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:88723893G>A	ENST00000301012.3	-	4	383	c.354C>T	c.(352-354)ttC>ttT	p.F118F	MVD_ENST00000568709.1_5'UTR	NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	118					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CAGCCGTGGGGAAGTTGTTCA	0.701000													6	13					0	0	1	0	0
C22orf43	51233	broad.mit.edu	37	22	23956368	23956368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23956368G>A	ENST00000317749.5	-	9	872	c.575C>T	c.(574-576)tCa>tTa	p.S192L		NM_016449.3	NP_057533.2	Q6PGQ1	CV043_HUMAN	chromosome 22 open reading frame 43	192	Asp-rich.									endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						GTGTCTCAGTGAGCATCTTAA	0.443000													17	110					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61761051	61761051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:61761051C>T	ENST00000577390.1	-	9	2437	c.1483G>A	c.(1483-1485)Gaa>Aaa	p.E495K	CDH8_ENST00000299345.6_Missense_Mutation_p.E495K|CDH8_ENST00000577730.1_Missense_Mutation_p.E495K|CDH8_ENST00000584337.1_Missense_Mutation_p.E495K	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	495	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GATGCGAATTCAGGGGCGTTG	0.393000													60	137					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46888191	46888191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46888191C>T	ENST00000359759.4	+	2	1408	c.1387C>T	c.(1387-1389)Ctt>Ttt	p.L463F	COL18A1_ENST00000355480.5_Missense_Mutation_p.L228F|COL18A1_ENST00000400337.2_Missense_Mutation_p.L48F			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	463	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GCTGCAGCTCCTTGGGGACCC	0.672000													28	71					0	0	1	0	0
OR52A1	23538	broad.mit.edu	37	11	5173285	5173285	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5173285G>A	ENST00000380367.1	-	2	732	c.315C>T	c.(313-315)ttC>ttT	p.F105F	OR52A1_ENST00000328942.1_Silent_p.F105F			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	105					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGTGTGGATGAACCACATTT	0.443000													11	26					0	0	1	0	0
METTL22	79091	broad.mit.edu	37	16	8738571	8738571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:8738571C>T	ENST00000381920.3	+	10	1426	c.1168C>T	c.(1168-1170)Ctc>Ttc	p.L390F	METTL22_ENST00000568967.1_3'UTR|METTL22_ENST00000561758.1_Missense_Mutation_p.L334F	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	390							methyltransferase activity			large_intestine(5)|lung(4)	9						TTACGAGCGCCTCCAGCAACT	0.632000													11	33					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047963	9047963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9047963G>A	ENST00000397910.4	-	5	33871	c.33668C>T	c.(33667-33669)tCa>tTa	p.S11223L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11225	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTTAGATTTGAAAACGCACT	0.478000													14	27					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101336183	101336183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101336183G>A	ENST00000392979.3	+	4	582	c.221G>A	c.(220-222)gGa>gAa	p.G74E	ANO4_ENST00000538618.1_Missense_Mutation_p.G275E|ANO4_ENST00000392977.3_Missense_Mutation_p.G109E|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	109						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						AAATCAAATGGACTTTACTTT	0.368000										HNSCC(74;0.22)			24	105					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922608	37922608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37922608G>A	ENST00000346872.3	-	8	1026	c.965C>T	c.(964-966)cCc>cTc	p.P322L	IKZF3_ENST00000346243.3_Missense_Mutation_p.P244L|IKZF3_ENST00000377944.3_Missense_Mutation_p.P179L|IKZF3_ENST00000377952.2_Missense_Mutation_p.P101L|IKZF3_ENST00000377945.3_Missense_Mutation_p.P188L|IKZF3_ENST00000467757.1_Missense_Mutation_p.P266L|IKZF3_ENST00000535189.1_Missense_Mutation_p.P288L|IKZF3_ENST00000439167.2_Missense_Mutation_p.P249L|IKZF3_ENST00000351680.3_Missense_Mutation_p.P283L|IKZF3_ENST00000439016.2_Missense_Mutation_p.P227L|IKZF3_ENST00000583368.1_Missense_Mutation_p.P75L|IKZF3_ENST00000394189.2_Missense_Mutation_p.P140L|IKZF3_ENST00000377958.2_Missense_Mutation_p.P235L|IKZF3_ENST00000350532.3_Missense_Mutation_p.P283L	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	322					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTGGACCAAGGGGCGCAGGGC	0.557000													31	39					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123279501	123279501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123279501C>T	ENST00000358487.5	-	7	1203	c.931G>A	c.(931-933)Gtt>Att	p.V311I	FGFR2_ENST00000356226.4_Missense_Mutation_p.V196I|FGFR2_ENST00000351936.6_Missense_Mutation_p.V311I|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000369056.1_Missense_Mutation_p.V311I|FGFR2_ENST00000369061.4_Intron|FGFR2_ENST00000346997.2_Missense_Mutation_p.V311I|FGFR2_ENST00000360144.3_Missense_Mutation_p.V222I|FGFR2_ENST00000369060.4_Missense_Mutation_p.V311I|FGFR2_ENST00000457416.2_Missense_Mutation_p.V311I|FGFR2_ENST00000357555.5_Missense_Mutation_p.V222I|FGFR2_ENST00000369059.1_Missense_Mutation_p.V196I|FGFR2_ENST00000478859.1_Missense_Mutation_p.V83I	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	311	Ig-like C2-type 3.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	ACCTTGAGAACCTTGAGGTAG	0.522000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				29	60					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060232	54060232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54060232C>T	ENST00000312233.2	-	3	910	c.344G>A	c.(343-345)gGc>gAc	p.G115D		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	115					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						CTTGGAAGGGCCCCCCAGATC	0.647000													10	51					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38192815	38192815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38192815G>A	ENST00000373048.4	-	8	1730	c.1731C>T	c.(1729-1731)ctC>ctT	p.L577L	EPHA10_ENST00000540011.1_Silent_p.L72L|EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000427468.2_Silent_p.L577L|EPHA10_ENST00000330210.7_Silent_p.L72L	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	577						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGCCCAGGACGAGGAGGGCCG	0.617000													25	42					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10782145	10782145	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10782145G>A	ENST00000416569.2	-	2	986	c.961_splice	c.e2+1	p.P320_splice	XKR6_ENST00000304437.2_Splice_Site_p.P41_splice	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	320						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		ggcACTCACAGGGCAGGGTCT	0.692000													9	67					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167666689	167666689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167666689G>A	ENST00000367854.3	+	6	1159	c.828G>A	c.(826-828)ccG>ccA	p.P276P	RCSD1_ENST00000537350.1_Silent_p.P246P	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	276	RCSD.									NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					GCCAGCACCCGGCCCAAGAGG	0.632000													5	13					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739306	55739306	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55739306G>A	ENST00000370830.3	-	1	1056	c.358C>T	c.(358-360)Ccc>Tcc	p.P120S	BMP5_ENST00000446683.2_Missense_Mutation_p.P120S	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	120					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TACCCATTGGGAGAGGCTGGG	0.517000													42	106					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45810908	45810908	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45810908G>A	ENST00000397928.1	+	10	1885	c.1440_splice	c.e10+1	p.K480_splice	TRPM2_ENST00000397932.2_Splice_Site_p.K480_splice|TRPM2_ENST00000300482.5_Splice_Site_p.K480_splice|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Splice_Site_p.K480_splice	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	480						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GGCAGTGGAAGGTAAGTCTTC	0.577000													21	64					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48628970	48628970	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48628970C>G	ENST00000328333.8	-	12	1670	c.1563G>C	c.(1561-1563)ggG>ggC	p.G521G	COL7A1_ENST00000454817.1_Silent_p.G521G	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	521	Fibronectin type-III 4.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCACCCGCTGCCCGGGCAGCT	0.662000													16	120					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5434069	5434069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:5434069G>A	ENST00000341928.2	-	7	997	c.657C>T	c.(655-657)ccC>ccT	p.P219P	EPB41L3_ENST00000540638.2_Silent_p.P219P|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000400111.3_Silent_p.P219P|EPB41L3_ENST00000544123.1_Silent_p.P219P|EPB41L3_ENST00000342933.3_Silent_p.P219P	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	219	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						CAAAGGAGCAGGGCAGCCTTC	0.527000													23	94					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52853451	52853451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52853451G>A	ENST00000266041.4	-	17	2131	c.2035C>T	c.(2035-2037)Cct>Tct	p.P679S	ITIH4_ENST00000485816.1_Missense_Mutation_p.P684S|ITIH4_ENST00000434759.3_3'UTR|ITIH4_ENST00000406595.1_Missense_Mutation_p.P649S|ITIH4_ENST00000346281.5_Missense_Mutation_p.P649S	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	679					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GCATGGTCAGGAACATCAGGA	0.602000													27	87					0	0	1	0	0
TRIM69	140691	broad.mit.edu	37	15	45050878	45050878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45050878C>T	ENST00000558173.1	+	2	4772	c.27C>T	c.(25-27)ttC>ttT	p.F9F	TRIM69_ENST00000338264.4_Silent_p.F54F|TRIM69_ENST00000561043.1_Intron|TRIM69_ENST00000559390.1_Silent_p.F213F|TRIM69_ENST00000558329.1_Silent_p.F9F|TRIM69_ENST00000329464.4_Silent_p.F213F|TRIM69_ENST00000560442.1_Silent_p.F9F			Q86WT6	TRI69_HUMAN	tripartite motif containing 69	213	Necessary for nuclear localization (By similarity).				apoptosis	nuclear speck	zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(9)|skin(1)	20		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		TGCATCAGTTCCTGCACAGCA	0.458000													20	51					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54307795	54307795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54307795G>A	ENST00000545554.1	+	1	2695	c.2695G>A	c.(2695-2697)Gat>Aat	p.D899N	UNC13C_ENST00000537900.1_Missense_Mutation_p.D899N|UNC13C_ENST00000260323.11_Missense_Mutation_p.D899N			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	899					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TACTGAAACAGATGAACAAAT	0.378000													31	100					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800866	185800866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185800866G>A	ENST00000302277.6	+	4	1337	c.743G>A	c.(742-744)aGa>aAa	p.R248K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	248						intracellular	zinc ion binding	p.R248I(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GGATTTAGCAGAAAAAGTAGA	0.428000													45	138					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101684039	101684039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101684039C>T	ENST00000261637.4	+	7	896	c.722C>T	c.(721-723)tCc>tTc	p.S241F		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	241					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						ATGTTTCACTCCTGTACAGGC	0.393000													10	40					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50099865	50099865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50099865C>T	ENST00000418929.2	+	4	2285	c.2273C>T	c.(2272-2274)gCc>gTc	p.A758V		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	466							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GAGCTGGGGGCCTTCTTGCAA	0.687000													9	19					0	0	1	0	0
WDPCP	51057	broad.mit.edu	37	2	63631777	63631777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:63631777G>A	ENST00000409120.1	-	4	3815	c.265C>T	c.(265-267)Cgc>Tgc	p.R89C	WDPCP_ENST00000409199.1_Missense_Mutation_p.R89C|WDPCP_ENST00000272321.7_Missense_Mutation_p.R281C|WDPCP_ENST00000409835.1_5'UTR|WDPCP_ENST00000409562.3_Missense_Mutation_p.R281C|WDPCP_ENST00000398544.3_Missense_Mutation_p.R122C			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	281					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						CATTCTGTGCGGACAGAACTC	0.433000													43	83					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813462	106813462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106813462C>T	ENST00000407775.2	+	8	1402	c.1152C>T	c.(1150-1152)ctC>ctT	p.L384L	ZFPM2_ENST00000520492.1_Silent_p.L252L|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Silent_p.L115L|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Silent_p.L252L|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	384					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ACCAGGAGCTCCATGTCCCTA	0.507000													25	141					0	0	1	0	0
AMTN	401138	broad.mit.edu	37	4	71396858	71396858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71396858C>T	ENST00000339336.4	+	8	590	c.460C>T	c.(460-462)Cca>Tca	p.P154S	AMTN_ENST00000504451.1_Missense_Mutation_p.P153S	NM_212557.2	NP_997722.1	Q6UX39	AMTN_HUMAN	amelotin	154					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				NS(3)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)|skin(1)	19			Lung(101;0.235)			TGGAAGCCTTCCAGCAGGAGG	0.592000													22	43					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932503	83932503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83932503C>T	ENST00000345382.2	-	4	1585	c.1500G>A	c.(1498-1500)gaG>gaA	p.E500E	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Silent_p.E493E	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	500					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						TGTTTGCTACCTCGGCAGGCG	0.527000													33	62					0	0	1	0	0
KLHL12	59349	broad.mit.edu	37	1	202861773	202861773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202861773G>A	ENST00000367261.3	-	12	1813	c.1595C>T	c.(1594-1596)tCc>tTc	p.S532F	KLHL12_ENST00000367259.1_Missense_Mutation_p.P203S|KLHL12_ENST00000435533.3_Missense_Mutation_p.S570F	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	532	Interaction with DVL3.				Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			ACTTAGCAGGGAATTACCATC	0.488000													14	58					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873207	55873207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55873207C>T	ENST00000313503.1	+	1	689	c.689C>T	c.(688-690)tCc>tTc	p.S230F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					AAAATTAATTCCACTTCAGGA	0.373000										HNSCC(53;0.14)			41	91					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232941087	232941087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:232941087C>T	ENST00000418460.1	+	1	445	c.318C>T	c.(316-318)atC>atT	p.I106I		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		TTCCGCAAATCTCGCGAGATA	0.602000													15	56					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36759506	36759506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36759506G>A	ENST00000416516.2	-	4	2238	c.1748C>T	c.(1747-1749)tCt>tTt	p.S583F		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	583	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						CTCACCATCAGAGATATTGTC	0.552000													64	134					0	0	1	0	0
DBF4B	80174	broad.mit.edu	37	17	42825720	42825720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42825720C>T	ENST00000315005.3	+	13	1214	c.1076C>T	c.(1075-1077)tCc>tTc	p.S359F	DBF4B_ENST00000393547.2_Missense_Mutation_p.S359F	NM_145663.2	NP_663696.1	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B (S. cerevisiae)	359					cell cycle	nucleus	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)	7		Prostate(33;0.0322)				TGGTCAGGTTCCCCAGCTTCT	0.592000													48	101					0	0	1	0	0
PHF14	9678	broad.mit.edu	37	7	11068332	11068332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:11068332C>T	ENST00000403050.3	+	7	1794	c.1342C>T	c.(1342-1344)Cgc>Tgc	p.R448C	PHF14_ENST00000445996.2_Missense_Mutation_p.R163C	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	448							zinc ion binding	p.R448C(1)		NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		TGAAGACCCTCGCTTTGCTAG	0.433000													18	35					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9804648	9804648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9804648C>T	ENST00000256460.3	-	5	556	c.379G>A	c.(379-381)Gat>Aat	p.D127N	OGG1_ENST00000302036.7_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	127	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TTCACAGCATCCAGCACCTGG	0.607000													15	42					0	0	1	0	0
PARN	5073	broad.mit.edu	37	16	14711453	14711453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:14711453G>A	ENST00000437198.2	-	6	523	c.382C>T	c.(382-384)Cga>Tga	p.R128*	PARN_ENST00000341484.7_Nonsense_Mutation_p.R67*|PARN_ENST00000539279.1_Intron|PARN_ENST00000420015.2_Nonsense_Mutation_p.R82*|PARN_ENST00000566021.1_Intron	NM_001134477.2|NM_002582.3	NP_001127949.1|NP_002573.1	O95453	PARN_HUMAN	poly(A)-specific ribonuclease	128					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding	p.R128*(2)		cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|urinary_tract(1)	21						TTACCATTTCGAAAAACTTTA	0.358000													11	42					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60168850	60168850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:60168850C>T	ENST00000261187.4	+	4	938	c.774C>T	c.(772-774)ttC>ttT	p.F258F	SLC16A7_ENST00000543448.1_Silent_p.F159F|SLC16A7_ENST00000552432.1_Silent_p.F258F|SLC16A7_ENST00000552024.1_Silent_p.F258F|SLC16A7_ENST00000547379.1_Silent_p.F258F	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	258						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TCATTATGTTCCTAGGTTTTT	0.363000													8	107					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113218404	113218404	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113218404G>A	ENST00000295872.4	-	4	432	c.173C>T	c.(172-174)tCg>tTg	p.S58L		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	58					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						TCTATTCTTCGATTTGTGTAT	0.368000													15	29					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43351577	43351577	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43351577C>T	ENST00000395891.1	+	4	848	c.243C>T	c.(241-243)ctC>ctT	p.L81L	HECW1_ENST00000453890.1_Silent_p.L81L	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	81					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GCTCCACGCTCATGGTCAGCA	0.612000													21	73					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154886389	154886389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:154886389C>T	ENST00000460393.1	+	19	2009	c.1889C>T	c.(1888-1890)tCc>tTc	p.S630F	MME_ENST00000360490.2_Missense_Mutation_p.S630F|MME_ENST00000462745.1_Missense_Mutation_p.S630F|MME_ENST00000492661.1_Missense_Mutation_p.S630F|MME_ENST00000493237.1_Missense_Mutation_p.S630F|MME-AS1_ENST00000484721.1_RNA	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	630					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GGAAACTTTTCCTGGGACCTG	0.403000													38	101					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5222750	5222750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5222750G>A	ENST00000372412.4	-	18	3289	c.3056C>T	c.(3055-3057)cCt>cTt	p.P1019L	PTPRS_ENST00000348075.2_Missense_Mutation_p.P996L|PTPRS_ENST00000587303.1_Missense_Mutation_p.P1018L|PTPRS_ENST00000588012.1_Missense_Mutation_p.P996L|PTPRS_ENST00000588552.1_Intron|PTPRS_ENST00000353284.2_Intron|PTPRS_ENST00000262963.6_Missense_Mutation_p.P1014L|PTPRS_ENST00000592099.1_Intron|PTPRS_ENST00000357368.4_Missense_Mutation_p.P1018L			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1018	Fibronectin type-III 7.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GAAGGGGCCAGGGCCCCGGCG	0.746000													8	29					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40655966	40655966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40655966C>T	ENST00000267889.3	+	2	347	c.260C>T	c.(259-261)cCc>cTc	p.P87L		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	87					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCATCCAGCCCCTTGGCCCCT	0.652000													24	86					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115349528	115349528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115349528G>A	ENST00000369358.4	-	41	5253	c.5009C>T	c.(5008-5010)aCc>aTc	p.T1670I	NRAP_ENST00000360478.3_Missense_Mutation_p.T1627I|NRAP_ENST00000369360.3_Missense_Mutation_p.T1635I|NRAP_ENST00000359988.3_Missense_Mutation_p.T1662I			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1662						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		AACACCTCTGGTCAGGTTCAA	0.542000													28	94					0	0	1	0	0
CLSPN	63967	broad.mit.edu	37	1	36202572	36202572	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36202572G>A	ENST00000251195.5	-	24	3948	c.3852C>T	c.(3850-3852)gtC>gtT	p.V1284V	CLSPN_ENST00000520551.1_Silent_p.V1231V|CLSPN_ENST00000373220.3_Silent_p.V1220V|CLSPN_ENST00000318121.3_Silent_p.V1284V|CLSPN_ENST00000466308.1_5'UTR			Q9HAW4	CLSPN_HUMAN	claspin	1284					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTGTATGAAAGACAAAGTTTC	0.468000													49	93					0	0	1	0	0
NSMF	26012	broad.mit.edu	37	9	140347008	140347008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140347008G>A	ENST00000371475.3	-	11	1393	c.1162C>T	c.(1162-1164)Ctt>Ttt	p.L388F	NSMF_ENST00000265663.7_Missense_Mutation_p.L386F|NSMF_ENST00000339554.3_Missense_Mutation_p.L185F|NSMF_ENST00000371473.3_Missense_Mutation_p.L358F|NSMF_ENST00000484316.1_5'UTR|NSMF_ENST00000541195.1_Missense_Mutation_p.L185F|NSMF_ENST00000392812.4_Missense_Mutation_p.L365F|NSMF_ENST00000371472.2_Missense_Mutation_p.L386F|NSMF_ENST00000371468.1_3'UTR|NSMF_ENST00000371482.1_Missense_Mutation_p.L52F|NSMF_ENST00000371474.3_Missense_Mutation_p.L363F|NSMF_ENST00000437259.1_Missense_Mutation_p.L365F	NM_001130969.1	NP_001124441.1			NMDA receptor synaptonuclear signaling and neuronal migration factor																		CACATACCAAGGATGTCCTCG	0.657000													8	40					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9001395	9001395	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9001395C>T	ENST00000299698.7	+	16	2093	c.1913C>T	c.(1912-1914)cCa>cTa	p.P638L	A2ML1_ENST00000539547.1_Missense_Mutation_p.P147L	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	482						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						GTGTCTGGCCCATGGGACTTT	0.552000													42	226					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31342524	31342524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31342524C>T	ENST00000544665.3	+	29	3389	c.3318C>T	c.(3316-3318)ccC>ccT	p.P1106P	ITGAM_ENST00000287497.8_Silent_p.P1105P	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1105					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TCCCCAACCCCCTGCCGCTCA	0.672000													23	39					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100831	93100831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:93100831G>A	ENST00000544406.2	+	2	690	c.424G>A	c.(424-426)Gaa>Aaa	p.E142K	C12orf74_ENST00000397833.3_Missense_Mutation_p.E142K			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	142										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						GCCTGTCAATGAAGGGTCCCT	0.587000													27	53					0	0	1	0	0
PCDHB17P	54661	broad.mit.edu	37	5	140536603	140536603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140536603G>A	ENST00000539533.1	+	1	1027	c.1027G>A	c.(1027-1029)Gac>Aac	p.D343N																								GGATATAAACGACAACGCACC	0.448000													4	6					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267675	71267675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:71267675G>A	ENST00000554752.2	-	2	528	c.529C>T	c.(529-531)Cct>Tct	p.P177S	MAP3K9_ENST00000555993.2_Missense_Mutation_p.P177S|MAP3K9_ENST00000381250.4_Missense_Mutation_p.P177S			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	177	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TCCTCATCAGGGTCGTGGCGA	0.537000													15	142					0	0	1	0	0
C2orf76	130355	broad.mit.edu	37	2	120097505	120097505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120097505G>A	ENST00000409466.2	-	3	552	c.31C>T	c.(31-33)Cgc>Tgc	p.R11C	C2orf76_ENST00000498049.1_5'UTR|C2orf76_ENST00000409523.1_Missense_Mutation_p.R11C|C2orf76_ENST00000409877.1_Missense_Mutation_p.R11C|C2orf76_ENST00000334816.7_Missense_Mutation_p.R11C			Q3KRA6	CB076_HUMAN	chromosome 2 open reading frame 76	11										large_intestine(1)|lung(3)|pancreas(1)	5						CGGATGAGGCGAACTGTGATG	0.433000													17	60					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89925205	89925205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89925205G>A	ENST00000405460.2	+	9	1784	c.1688G>A	c.(1687-1689)gGa>gAa	p.G563E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	563					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATTCCTGCTGGAGCTGTGGAC	0.403000													11	57					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62415387	62415387	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62415387G>A	ENST00000330574.2	-	2	2217	c.2165C>T	c.(2164-2166)tCt>tTt	p.S722F		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	722					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						AGAAGCCAAAGAAGCTGAAAC	0.537000													10	69					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6590866	6590866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6590866G>A	ENST00000433363.2	-	11	1790	c.1557C>T	c.(1555-1557)caC>caT	p.H519H	SLC13A5_ENST00000381074.4_Silent_p.H476H|SLC13A5_ENST00000573648.1_Intron|SLC13A5_ENST00000293800.6_Silent_p.H502H	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	519						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						CAACCTTGAGGTGCCCATAGG	0.498000													36	66					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160793318	160793318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160793318C>T	ENST00000263285.5	+	8	1592	c.1562C>T	c.(1561-1563)cCc>cTc	p.P521L	LY9_ENST00000341032.4_Missense_Mutation_p.P417L|LY9_ENST00000368035.1_Missense_Mutation_p.P159L|LY9_ENST00000368040.1_Missense_Mutation_p.P159L|LY9_ENST00000368041.2_Missense_Mutation_p.P391L	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	521					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTGGACACTCCCCTCAGGCCT	0.557000													19	37					0	0	1	0	0
TRBV4-1	28617	broad.mit.edu	37	7	142013265	142013265	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142013265G>A	ENST00000390357.3	+	0	149																											AGAAGTCTTTGAAATGTGAAC	0.438000													33	78					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121350818	121350818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121350818C>T	ENST00000314583.3	-	14	1427	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Missense_Mutation_p.E409K	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	446	SH3.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		AAGGAAAGCTCATCACTTCCC	0.517000													48	132					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30585176	30585176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30585176G>A	ENST00000217299.3	+	3	1830	c.1656G>A	c.(1654-1656)gaG>gaA	p.E552E		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	552						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGGCACTGGAGTACTCCTCAC	0.602000													22	98					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149430317	149430317	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149430317C>T	ENST00000255992.10	+	18	2670	c.2271C>T	c.(2269-2271)ctC>ctT	p.L757L	KRBA1_ENST00000485033.2_Silent_p.L697L|KRBA1_ENST00000319551.8_Silent_p.L697L|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	758	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGAGGCTGCTCCCCCAGGGCC	0.642000													47	186					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38897326	38897326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38897326G>A	ENST00000359357.3	+	73	10761	c.10507G>A	c.(10507-10509)Gag>Aag	p.E3503K	RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.E3720K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E3467K|RP1-207H1.3_ENST00000453417.1_RNA|RP1-207H1.3_ENST00000418399.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CACACACTTGGAGGACAGCCT	0.408000													68	152					0	0	1	0	0
C1orf111	284680	broad.mit.edu	37	1	162344300	162344300	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:162344300C>T	ENST00000367935.4	-	3	403	c.324G>A	c.(322-324)gaG>gaA	p.E108E	C1orf111_ENST00000493255.1_5'UTR|RP11-565P22.6_ENST00000431696.1_Intron	NM_182581.3	NP_872387.2	Q5T0L3	CA111_HUMAN	chromosome 1 open reading frame 111	108										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11	all_hematologic(112;0.15)		BRCA - Breast invasive adenocarcinoma(70;0.0938)			CCAGCTGGCTCTCTTTGTCTG	0.572000													64	178					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3085322	3085322	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3085322C>T	ENST00000397461.1	+	22	3129	c.2745C>T	c.(2743-2745)tcC>tcT	p.S915S	CNTN4_ENST00000418658.1_Silent_p.S915S|CNTN4_ENST00000448906.2_Silent_p.S587S|CNTN4_ENST00000358480.3_Silent_p.S696S|CNTN4_ENST00000397459.2_Silent_p.S587S|CNTN4_ENST00000427331.1_Silent_p.S915S|CNTN4-AS1_ENST00000442749.2_RNA	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	915	Fibronectin type-III 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CATCAGACTCCAAAATTATCC	0.368000													23	67					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104643604	104643604	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104643604C>T	ENST00000315264.7	+	11	4440	c.4062C>T	c.(4060-4062)ccC>ccT	p.P1354P	KIF26A_ENST00000423312.2_Silent_p.P1493P			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1493					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCCCCAAGCCCCCTGTTGGTG	0.706000													5	10					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76990361	76990361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76990361G>A	ENST00000315938.4	-	3	387	c.137C>T	c.(136-138)tCa>tTa	p.S46L	GDPD4_ENST00000376217.2_Missense_Mutation_p.S46L|GDPD4_ENST00000527489.1_Intron	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	46					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						CAACAGCAATGAAGAGTAGGC	0.428000													14	36					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20585753	20585753	+	Missense_Mutation	SNP	C	C	T	rs150087607		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20585753C>T	ENST00000315543.4	+	1	188	c.188C>T	c.(187-189)tCg>tTg	p.S63L		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GCCCTCTTCTCGGTTATCTAT	0.408000													102	288					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4554475	4554475	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4554475G>A	ENST00000586582.1	-	9	1006	c.696C>T	c.(694-696)gtC>gtT	p.V232V	SEMA6B_ENST00000586965.1_Silent_p.V232V|SEMA6B_ENST00000301293.3_Silent_p.V232V	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	232	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCGCATGGACAAAGTAAG	0.547000													11	30					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56035641	56035641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56035641G>A	ENST00000244728.5	-	5	1229	c.832C>T	c.(832-834)Cct>Tct	p.P278S	COL21A1_ENST00000535941.1_Missense_Mutation_p.P278S|COL21A1_ENST00000370819.1_Missense_Mutation_p.P278S	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	278	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TATGATGGAGGAAGACCTTCT	0.358000													5	25					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170549	207170549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207170549G>A	ENST00000374423.3	+	5	1683	c.1297G>A	c.(1297-1299)Gaa>Aaa	p.E433K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	433							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CCTTTCCAAGGAAGTACGTAC	0.353000													29	66					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17450006	17450006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17450006C>T	ENST00000324894.8	+	6	807	c.739C>T	c.(739-741)Cgc>Tgc	p.R247C	GTPBP3_ENST00000600625.1_Missense_Mutation_p.R247C|GTPBP3_ENST00000358792.7_Missense_Mutation_p.R279C|GTPBP3_ENST00000361619.5_Missense_Mutation_p.R269C|GTPBP3_ENST00000598038.1_3'UTR	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	247					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						GCAGAGGCTCCGCTCAGGGGT	0.662000													19	30					0	0	1	0	0
ACVR2B	93	broad.mit.edu	37	3	38520723	38520723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38520723C>T	ENST00000352511.3	+	6	1243	c.771C>T	c.(769-771)ctC>ctT	p.L257L		NM_001106.3	NP_001097.2	Q13705	AVR2B_HUMAN	activin A receptor, type IIB	257	Protein kinase.				activin receptor signaling pathway|anterior/posterior pattern formation|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|regulation of transcription, DNA-dependent	cell surface|cytoplasm|integral to plasma membrane	activin receptor activity|ATP binding|growth factor binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			lung(1)	1	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0565)|Kidney(284;0.071)		GCTCCAACCTCGAAGTAGAGC	0.557000													62	144					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11199665	11199665	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11199665G>A	ENST00000361445.4	-	35	4999	c.4923C>T	c.(4921-4923)tcC>tcT	p.S1641S	MTOR_ENST00000495435.1_5'UTR	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1641	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TGACCACAAGGGACCGCACCA	0.502000													60	154					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189898822	189898822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189898822C>T	ENST00000374866.3	-	54	4748	c.4474G>A	c.(4474-4476)Gaa>Aaa	p.E1492K		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1492	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGCCCAATTTCAACGCCGAAT	0.463000													30	53					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21628917	21628917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21628917G>A	ENST00000328843.6	+	12	2096	c.2065G>A	c.(2065-2067)Gaa>Aaa	p.E689K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E689K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	689	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TATCTATAATGAATGGAAAAG	0.343000									Kartagener syndrome				10	75					0	0	1	0	0
KIZ-AS1	101929591	broad.mit.edu	37	20	21143493	21143493	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:21143493C>T	ENST00000591761.1	-	0	5085				RP5-872K7.7_ENST00000425746.2_RNA|PLK1S1_ENST00000457464.1_RNA																							ACTTGCAGATCATCTTGCTCA	0.443000													10	24					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69665943	69665943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:69665943C>T	ENST00000370598.1	+	7	2044	c.1223C>T	c.(1222-1224)tCg>tTg	p.S408L		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	408	TSP type-1 3.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GAGTGGAGTTCGTGGAGCCAG	0.527000													13	30					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55021669	55021669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:55021669C>T	ENST00000324000.3	+	2	2250	c.216C>T	c.(214-216)ttC>ttT	p.F72F		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	72					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		ACCCGTCATTCGTGCCCATTA	0.498000													29	164					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138633243	138633243	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:138633243T>A	ENST00000218099.2	+	6	550	c.543T>A	c.(541-543)gtT>gtA	p.V181V	F9_ENST00000394090.2_Silent_p.V143V	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	181					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	GTGGAAGAGTTTCTGTTTCAC	0.348000													28	17					0	0	1	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79854699	79854699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79854699G>A	ENST00000338682.3	-	5	1812	c.1140C>T	c.(1138-1140)acC>acT	p.T380T		NM_001004441.2	NP_001004441.2	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	380						cytoplasm|nucleus				NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	28		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		AAGTTGGAGGGGTAAGGCCAG	0.428000													24	53					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4787833	4787833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4787833C>T	ENST00000299320.5	+	3	640	c.162C>T	c.(160-162)ttC>ttT	p.F54F	C16orf71_ENST00000590191.1_Silent_p.F54F|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	54										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						TGTTCATCTTCCAGCGAAACC	0.597000													27	66					0	0	1	0	0
ASIC5	51802	broad.mit.edu	37	4	156757929	156757929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156757929G>A	ENST00000537611.2	-	8	1193	c.1147C>T	c.(1147-1149)Ccg>Tcg	p.P383S		NM_017419.2	NP_059115.1	Q9NY37	ACCN5_HUMAN	acid-sensing (proton-gated) ion channel family member 5	383						integral to membrane|plasma membrane											ATAGTGGCCGGGTATTCTATT	0.363000													43	97					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167494	140167494	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140167494G>A	ENST00000458420.3	+	6	1111	c.921G>A	c.(919-921)ggG>ggA	p.G307G		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	307					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						ATTACATTGGGAAGGGTTGTG	0.483000										HNSCC(16;0.037)			22	119					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3658723	3658723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:3658723C>T	ENST00000404826.2	+	2	449	c.310C>T	c.(310-312)Cca>Tca	p.P104S	SDK1_ENST00000389531.3_Missense_Mutation_p.P104S	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	104	Ig-like C2-type 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGATGTTGCTCCATATTTTAA	0.398000													6	18					0	0	1	0	0
FGF23	8074	broad.mit.edu	37	12	4479590	4479590	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4479590C>T	ENST00000237837.1	-	3	820	c.675G>A	c.(673-675)ggG>ggA	p.G225G		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	225					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CCCTGACCACCCCTAATGGGT	0.697000													14	43					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18462396	18462396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:18462396C>T	ENST00000338745.6	-	2	1798	c.64G>A	c.(64-66)Gat>Aat	p.D22N	SATB1_ENST00000493952.2_Missense_Mutation_p.D22N|SATB1_ENST00000454909.2_Missense_Mutation_p.D22N|SATB1_ENST00000417717.2_Missense_Mutation_p.D22N|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	22					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						CCCTTCGGATCACTCACATTG	0.498000													64	122					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169539831	169539831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169539831C>T	ENST00000340806.6	+	1	122	c.122C>T	c.(121-123)cCt>cTt	p.P41L		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	41										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ACTGCCATTCCTTTGGAGATC	0.383000													35	84					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38610501	38610501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38610501G>A	ENST00000222345.6	+	9	3356	c.2847G>A	c.(2845-2847)agG>agA	p.R949R		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	949					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGACATAAGGGAGATAGTGC	0.532000													12	37					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141598235	141598235	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141598235T>A	ENST00000442267.2	-	6	946	c.872A>T	c.(871-873)aAg>aTg	p.K291M		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	291						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TCTCTCACTCTTTGCCCTGGC	0.423000													46	95					0	0	1	0	0
IRF6	3664	broad.mit.edu	37	1	209961772	209961772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209961772G>A	ENST00000367021.3	-	9	1569	c.1397C>T	c.(1396-1398)cCc>cTc	p.P466L	IRF6_ENST00000542854.1_Missense_Mutation_p.P371L	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	466					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CAATTACTGGGGAGGCAGGGC	0.458000										HNSCC(57;0.16)			16	43					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173787010	173787010	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:173787010G>A	ENST00000397081.3	+	6	662	c.517_splice	c.e6-1	p.R173_splice	RAPGEF4_ENST00000409036.1_Splice_Site_p.R173_splice|RAPGEF4_ENST00000539331.1_Splice_Site_p.R20_splice|RAPGEF4_ENST00000473043.1_3'UTR|RAPGEF4_ENST00000538974.1_Splice_Site_p.R20_splice|RAPGEF4_ENST00000397087.3_Splice_Site_p.R29_splice|RAPGEF4_ENST00000540783.1_Splice_Site_p.R20_splice|RAPGEF4_ENST00000264111.6_Intron	NM_007023.3	NP_008954.2	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	173					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CTCCTTTAGGGATTCCTGACA	0.368000													82	207					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543236	28543236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28543236C>T	ENST00000452236.2	-	3	1863	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	416	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TGTGCAACTTCCGTAGGCCTT	0.388000													21	62					0	0	1	0	0
TFPI	7035	broad.mit.edu	37	2	188332533	188332533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:188332533C>T	ENST00000233156.3	-	7	1049	c.755G>A	c.(754-756)gGa>gAa	p.G252E	AC007319.1_ENST00000412276.1_RNA|AC007319.1_ENST00000453517.1_RNA|TFPI_ENST00000392365.1_Missense_Mutation_p.G252E	NM_006287.4	NP_006278.1	P10646	TFPI1_HUMAN	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	252	BPTI/Kunitz inhibitor 3.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	GTTTTCATTTCCCCCACATCC	0.393000													41	118					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510576	56510576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56510576G>A	ENST00000302957.3	-	1	711	c.712C>T	c.(712-714)Ctg>Ttg	p.L238L		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AGGATAGCCAGGAGGATGTTG	0.478000													10	97					0	0	1	0	0
FCER1G	2207	broad.mit.edu	37	1	161188701	161188701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161188701G>A	ENST00000289902.1	+	5	254	c.229G>A	c.(229-231)Gag>Aag	p.E77K	FCER1G_ENST00000367992.3_Intron|FCER1G_ENST00000490414.1_3'UTR	NM_004106.1	NP_004097.1	P30273	FCERG_HUMAN	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	77	ITAM.				platelet activation	integral to plasma membrane				endometrium(1)|lung(5)	6	all_cancers(52;1.35e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Benzylpenicilloyl Polylysine(DB00895)	GGAGACTTACGAGACTCTGAA	0.542000													26	82					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52822481	52822481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52822481C>T	ENST00000252245.5	-	6	1302	c.1082G>A	c.(1081-1083)cGa>cAa	p.R361Q		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	361	Coil 2.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		TTTGGTGTTTCGAAGGTCATC	0.527000													12	79					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167802338	167802338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167802338G>A	ENST00000367848.1	-	25	3701	c.3204C>T	c.(3202-3204)ctC>ctT	p.L1068L	ADCY10_ENST00000545172.1_Silent_p.L1007L|ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.L1160L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1160					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTCGGTTGAGGAGCTTCAGTG	0.453000													101	246					0	0	1	0	0
OLFM4	10562	broad.mit.edu	37	13	53603060	53603060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:53603060C>T	ENST00000219022.2	+	1	167	c.89C>T	c.(88-90)cCc>cTc	p.P30L		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	30					cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CCTCCAATTCCCAGCCCCGGC	0.602000													46	191					0	0	1	0	0
SCGB1D4	404552	broad.mit.edu	37	11	62065000	62065000	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62065000C>T	ENST00000358585.1	-	2	239	c.186G>A	c.(184-186)gtG>gtA	p.V62V		NM_206998.1	NP_996881.1	Q6XE38	SG1D4_HUMAN	secretoglobin, family 1D, member 4	62						extracellular region	binding			lung(1)|prostate(1)	2						TGCAGTGCTTCACTTCCAACT	0.428000													97	261					0	0	1	0	0
CIB1	10519	broad.mit.edu	37	15	90775465	90775465	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90775465G>A	ENST00000328649.6	-	3	342	c.181C>T	c.(181-183)Ctt>Ttt	p.L61F		NM_006384.3	NP_006375.2	Q99828	CIB1_HUMAN	calcium and integrin binding 1 (calmyrin)	61					apoptosis|cell adhesion|double-strand break repair	apical plasma membrane|endoplasmic reticulum|filopodium|nucleoplasm	calcium ion binding|protein binding			lung(1)|prostate(1)	2	Melanoma(11;0.00551)|Lung NSC(78;0.0141)|all_lung(78;0.0303)		BRCA - Breast invasive adenocarcinoma(143;0.00269)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			AGCTCTGGAAGGCTGAGAATC	0.597000													29	122					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51464870	51464870	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51464870C>T	ENST00000298355.3	-	7	2622	c.1501G>A	c.(1501-1503)Gat>Aat	p.D501N	TRIM9_ENST00000338969.5_Missense_Mutation_p.D497N|TRIM9_ENST00000360392.4_Missense_Mutation_p.D501N	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	501	Fibronectin type-III.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					TGAAGACCATCCACAGTGCAC	0.552000													21	67					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125836936	125836936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125836936G>A	ENST00000393434.2	-	17	2243	c.1894C>T	c.(1894-1896)Ctg>Ttg	p.L632L	ALDH1L1_ENST00000273450.3_Silent_p.L642L|ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000472186.1_Silent_p.L632L|ALDH1L1_ENST00000452905.2_Silent_p.L531L	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	632	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TGGCCGACCAGGGAGCCTGTG	0.627000													4	34					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73563112	73563112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73563112G>A	ENST00000224721.6	+	54	7827	c.7822G>A	c.(7822-7824)Gac>Aac	p.D2608N	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Missense_Mutation_p.D363N	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2603	Cadherin 24.		R -> H (in DFNB12).		calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GGAGGTCATCGACGTCAATGA	0.622000													3	11					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68882034	68882034	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:68882034C>T	ENST00000303786.3	+	3	928	c.508C>T	c.(508-510)Ctg>Ttg	p.L170L	PROKR1_ENST00000394342.2_Silent_p.L170L			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	170						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TGTCCATCCGCTGAGACCACG	0.498000													46	96					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92532279	92532279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92532279G>A	ENST00000298047.6	+	9	6117	c.6100G>A	c.(6100-6102)Gtc>Atc	p.V2034I	FAT3_ENST00000409404.2_Missense_Mutation_p.V2034I|FAT3_ENST00000525166.1_Missense_Mutation_p.V1884I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2034	Cadherin 18.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TACCTCAGGGGTCATTCAGAC	0.463000										TCGA Ovarian(4;0.039)			22	51					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131231365	131231365	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:131231365C>T	ENST00000298542.4	-	4	388	c.213G>A	c.(211-213)aaG>aaA	p.K71K	FRMD7_ENST00000464296.1_Intron	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	71	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					AAACAATCTCCTTAGGATCTT	0.388000													18	106					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79514186	79514186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79514186G>A	ENST00000537152.1	-	5	1994	c.1469C>T	c.(1468-1470)cCc>cTc	p.P490L	C17orf70_ENST00000327787.8_Missense_Mutation_p.P641L|C17orf70_ENST00000425898.2_Missense_Mutation_p.P290L	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	641					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CCTGCTCAGGGGCAGGCAAAC	0.692000													21	88					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203019	140203019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140203019C>T	ENST00000529859.1	+	1	1659	c.1659C>T	c.(1657-1659)ttC>ttT	p.F553F	PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000378126.3_Silent_p.F553F|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Silent_p.F553F	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGTGTTCGTGCTGGACG	0.706000													31	77					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76368516	76368516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:76368516C>T	ENST00000298832.9	+	31	3977	c.3772C>T	c.(3772-3774)Ctc>Ttc	p.L1258F		NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1258					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		GCTGAATGGACTCCAGAGCAG	0.572000													19	88					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855782	12855782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12855782C>T	ENST00000332296.7	+	4	1165	c.1062C>T	c.(1060-1062)ctC>ctT	p.L354L	PRAMEF1_ENST00000400814.3_Silent_p.L109L	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	354										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAAAACCCTCATCTTGGAGG	0.537000													63	357					0	0	1	0	0
PXK	54899	broad.mit.edu	37	3	58382778	58382778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58382778C>T	ENST00000463280.1	+	8	827	c.736C>T	c.(736-738)Ctt>Ttt	p.L246F	PXK_ENST00000356151.2_Missense_Mutation_p.L279F|PXK_ENST00000383716.3_Missense_Mutation_p.L246F|PXK_ENST00000484288.1_Missense_Mutation_p.L279F|PXK_ENST00000479241.1_Missense_Mutation_p.L262F|PXK_ENST00000302779.5_Missense_Mutation_p.L262F|PXK_ENST00000536660.1_Missense_Mutation_p.L142F|PXK_ENST00000383715.4_Missense_Mutation_p.L262F			Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	279	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		ACTGAAGTTTCTTCATGACAA	0.398000													52	119					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77257047	77257047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77257047G>A	ENST00000251089.2	-	9	1871	c.1759C>T	c.(1759-1761)Cgc>Tgc	p.R587C	ANGEL1_ENST00000557179.1_Missense_Mutation_p.R152C	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	587										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		ACCTCTGGGCGGCCACGCTGG	0.512000													4	42					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20691984	20691984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20691984G>A	ENST00000315519.2	+	1	194	c.116G>A	c.(115-117)aGg>aAg	p.R39K		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		CATGGTCAAAGGGAGATGCAG	0.463000													52	155					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4835838	4835838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4835838C>T	ENST00000252318.2	+	2	689	c.352C>T	c.(352-354)Ctc>Ttc	p.L118F	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	118						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CCAAATGAAACTCTTCCCACA	0.507000													11	26					0	0	1	0	0
ACTL6B	51412	broad.mit.edu	37	7	100244607	100244607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100244607G>A	ENST00000160382.5	-	10	1029	c.923C>T	c.(922-924)cCc>cTc	p.P308L		NM_016188.4	NP_057272.1	O94805	ACL6B_HUMAN	actin-like 6B	308					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GACGTTCGAGGGATCAAACAG	0.622000													7	55					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64664000	64664000	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64664000G>A	ENST00000421419.2	-	39	5481	c.5367C>T	c.(5365-5367)gcC>gcT	p.A1789A	ATG2A_ENST00000377264.3_Silent_p.A1787A			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1787							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						AGCCAAAGGAGGCAGCCCCTC	0.637000											OREG0004026	type=REGULATORY REGION|Gene=BC027481|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	14	29					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313046	54313046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54313046C>T	ENST00000324134.6	-	3	2035	c.1867G>A	c.(1867-1869)Gag>Aag	p.E623K	NLRP12_ENST00000391772.1_Missense_Mutation_p.E623K|NLRP12_ENST00000535162.1_Missense_Mutation_p.E623K|NLRP12_ENST00000391773.1_Missense_Mutation_p.E623K|NLRP12_ENST00000354278.3_Missense_Mutation_p.E623K|NLRP12_ENST00000391775.3_Missense_Mutation_p.E623K|NLRP12_ENST00000351894.4_Missense_Mutation_p.E623K|NLRP12_ENST00000345770.5_Missense_Mutation_p.E623K	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	623					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		ATAAACTCCTCCTCCTGGATC	0.567000													23	65					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136562429	136562429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136562429G>A	ENST00000264162.2	-	10	4382	c.4372C>T	c.(4372-4374)Cct>Tct	p.P1458S		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1458	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GTTCCATCAGGGAGGATGCGA	0.562000													20	37					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13397555	13397555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13397555G>A	ENST00000360228.5	-	20	3314	c.3315C>T	c.(3313-3315)ccC>ccT	p.P1105P	CACNA1A_ENST00000573710.2_Silent_p.P1106P	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1106			G -> S (in dbSNP:rs16027).		cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGGCCAGCATGGGGCCGGGGT	0.726000													6	18					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63525115	63525115	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:63525115C>T	ENST00000536984.2	+	8	1993	c.1299C>T	c.(1297-1299)gtC>gtT	p.V433V	CDH7_ENST00000397968.2_Silent_p.V433V|CDH7_ENST00000323011.3_Silent_p.V433V			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	433	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				ACAGTGGGGTCATCACAACTG	0.388000													28	114					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22157999	22157999	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22157999G>A	ENST00000374695.3	-	83	11488	c.11409C>T	c.(11407-11409)gaC>gaT	p.D3803D		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3803	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGGCACCATAGTCAGGATAGC	0.627000													14	66					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26691277	26691277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26691277G>A	ENST00000436292.1	-	4	880	c.760C>T	c.(760-762)Ctt>Ttt	p.L254F	ZNF683_ENST00000349618.3_Missense_Mutation_p.L254F|ZNF683_ENST00000403843.1_Missense_Mutation_p.L254F|ZNF683_ENST00000374204.1_Missense_Mutation_p.L254F			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGGTAGGGAAGCAGGGTCTCC	0.652000													34	43					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175334294	175334294	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175334294C>T	ENST00000367674.1	-	12	3147	c.2439G>A	c.(2437-2439)gaG>gaA	p.E813E	TNR_ENST00000263525.2_Silent_p.E813E	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	813	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TCTCTTCCTCCTCATCCCTGG	0.527000													25	46					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118343602	118343602	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118343602C>T	ENST00000534358.1	+	3	1751	c.1728C>T	c.(1726-1728)tcC>tcT	p.S576S	KMT2A_ENST00000389506.5_Silent_p.S576S|KMT2A_ENST00000354520.4_Silent_p.S576S	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AGCCAGCCTCCAGTATCTCTG	0.532000													38	84					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21245915	21245915	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21245915C>T	ENST00000233242.1	-	18	2732		c.e18-1			NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B						cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGCCTGCATCTATAAGTCAG	0.473000													29	72					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54959231	54959231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54959231G>A	ENST00000273286.5	-	2	181	c.19C>T	c.(19-21)Ctg>Ttg	p.L7L	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|LRTM1_ENST00000493075.1_5'UTR|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000490478.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	7						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		CTGGAAAACAGGAGCAGTTCA	0.463000													10	37					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23884842	23884842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23884842G>A	ENST00000355349.3	-	35	5315	c.5153C>T	c.(5152-5154)tCc>tTc	p.S1718F	CTD-2201G16.1_ENST00000557368.1_RNA	NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1718					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCTCACCTGGGAATGCAGCAG	0.597000													23	54					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725003	140725003	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140725003G>A	ENST00000253812.6	+	1	1403	c.1403G>A	c.(1402-1404)gGa>gAa	p.G468E	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1												p.G468E(1)		breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCCCAGAGGAGCCTCCATC	0.537000													33	245					0	0	1	0	0
KCNK17	89822	broad.mit.edu	37	6	39267378	39267378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39267378G>A	ENST00000373231.4	-	5	1056	c.824C>T	c.(823-825)tCc>tTc	p.S275F	KCNK17_ENST00000453413.2_3'UTR	NM_031460.3	NP_113648.2	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	275						integral to membrane	potassium channel activity|voltage-gated ion channel activity	p.S275F(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)	14						GTGGCAGCAGGAACATACCCT	0.562000													27	58					0	0	1	0	0
FBXL13	222235	broad.mit.edu	37	7	102665589	102665589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:102665589C>T	ENST00000393772.2	-	6	842	c.416G>A	c.(415-417)cGa>cAa	p.R139Q	FBXL13_ENST00000379305.3_Missense_Mutation_p.R139Q|FBXL13_ENST00000436908.1_Missense_Mutation_p.R139Q|FBXL13_ENST00000471074.1_5'UTR|FBXL13_ENST00000456695.1_Missense_Mutation_p.R139Q|FBXL13_ENST00000379308.3_Missense_Mutation_p.R139Q|FBXL13_ENST00000379306.3_Missense_Mutation_p.R139Q|FBXL13_ENST00000455112.2_Missense_Mutation_p.R139Q|FBXL13_ENST00000313221.4_Missense_Mutation_p.R139Q			Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13	139										NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|skin(3)|stomach(1)	27						AGAAGAACTTCGTTCAGGAAA	0.318000													7	44					0	0	1	0	0
KHDC3L	154288	broad.mit.edu	37	6	74073386	74073386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:74073386G>A	ENST00000370367.3	+	3	510	c.457G>A	c.(457-459)Gag>Aag	p.E153K		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		GGAGGTCCGGGAGGCCGGGAC	0.677000													26	33					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137716508	137716508	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137716508C>T	ENST00000371817.3	+	62	5175	c.4761C>T	c.(4759-4761)atC>atT	p.I1587I		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1587	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGCGGAACATCGACGCCAGCC	0.642000													13	41					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123485474	123485474	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123485474T>A	ENST00000529750.1	+	16	2147	c.1820T>A	c.(1819-1821)aTc>aAc	p.I607N	GRAMD1B_ENST00000456860.2_Missense_Mutation_p.I614N|GRAMD1B_ENST00000322282.7_Missense_Mutation_p.I607N|GRAMD1B_ENST00000450171.2_Missense_Mutation_p.I298N	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	607						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		ACGCGGCATATCCCGGAGGAC	0.547000													9	25					0	0	1	0	0
FAM76B	143684	broad.mit.edu	37	11	95521709	95521709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:95521709G>A	ENST00000358780.5	-	2	418	c.106C>T	c.(106-108)Cct>Tct	p.P36S	FAM76B_ENST00000536839.1_Missense_Mutation_p.P36S|FAM76B_ENST00000538047.1_5'UTR	NM_144664.4	NP_653265.3	Q5HYJ3	FA76B_HUMAN	family with sequence similarity 76, member B	36										breast(1)|kidney(1)|lung(1)	3		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTTACAATAGGATGTGCAATC	0.343000													9	59					0	0	1	0	0
MTERFD1	51001	broad.mit.edu	37	8	97258141	97258141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:97258141G>A	ENST00000523821.1	-	6	963	c.844C>T	c.(844-846)Cgt>Tgt	p.R282C	MTERFD1_ENST00000287025.3_Missense_Mutation_p.R282C|MTERFD1_ENST00000524341.1_Missense_Mutation_p.R92C|MTERFD1_ENST00000522822.1_Missense_Mutation_p.R161C			Q96E29	MTER1_HUMAN	MTERF domain containing 1	282					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	24	Breast(36;5.16e-05)					CTTGGGAGACGAACTACCAGA	0.363000													25	88					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31653928	31653928	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:31653928C>T	ENST00000395934.2	+	7	910	c.903C>T	c.(901-903)atC>atT	p.I301I	ELP4_ENST00000350638.5_Silent_p.I301I|ELP4_ENST00000379163.5_Silent_p.I302I			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	301					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					CCTGCATCATCACAATGCCAA	0.398000													43	74					0	0	1	0	0
CD300E	342510	broad.mit.edu	37	17	72619772	72619772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72619772C>T	ENST00000392619.1	-	1	105	c.70G>A	c.(70-72)Gga>Aga	p.G24R	CD300E_ENST00000328630.3_5'UTR|CD300E_ENST00000426295.2_Missense_Mutation_p.G38R	NM_181449.2	NP_852114.2	Q496F6	CLM2_HUMAN	CD300e molecule	0	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			breast(1)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	19						TTCCTGTCTCCTTGGCTTCCG	0.537000													40	82					0	0	1	0	0
CLDN4	1364	broad.mit.edu	37	7	73246037	73246037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73246037C>T	ENST00000435050.1	+	2	3186	c.506C>T	c.(505-507)gCc>gTc	p.A169V	CLDN4_ENST00000431918.1_Missense_Mutation_p.A169V|CLDN4_ENST00000340958.2_Missense_Mutation_p.A169V			O14493	CLD4_HUMAN	claudin 4	169					calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity			kidney(2)|lung(4)|urinary_tract(1)	7		Lung NSC(55;0.159)				GTCGGCTGGGCCGCCTCCGGC	0.642000													16	56					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	157999191	157999191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:157999191G>A	ENST00000264428.4	+	2	285	c.15G>A	c.(13-15)ttG>ttA	p.L5L	GLRB_ENST00000541722.1_Silent_p.L5L|GLRB_ENST00000509282.1_Silent_p.L5L|GLRB_ENST00000512619.1_Silent_p.L5L	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	5					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	AGTTTTTATTGACAACTGCCT	0.313000													7	43					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451765	55451765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55451765C>T	ENST00000446217.1	-	6	908	c.506G>A	c.(505-507)gGa>gAa	p.G169E	NLRP7_ENST00000592784.1_Missense_Mutation_p.G141E|NLRP7_ENST00000340844.2_Missense_Mutation_p.G141E|NLRP7_ENST00000588756.1_Missense_Mutation_p.G141E|NLRP7_ENST00000448121.2_Missense_Mutation_p.G141E|NLRP7_ENST00000328092.5_Missense_Mutation_p.G141E|NLRP7_ENST00000590030.1_Missense_Mutation_p.G141E			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	141							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GTCAATGTCTCCTTGCCAAAA	0.463000													178	453					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64461881	64461881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:64461881C>T	ENST00000358025.3	+	23	3131	c.2901C>T	c.(2899-2901)atC>atT	p.I967I	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000554584.1_Silent_p.I967I|SYNE2_ENST00000344113.4_Silent_p.I967I	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	967					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGAAACTTATCCGTAGAGGAA	0.294000													11	46					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23808660	23808660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23808660G>A	ENST00000354639.3	+	12	1858	c.1394G>A	c.(1393-1395)gGa>gAa	p.G465E	STK31_ENST00000433467.2_Missense_Mutation_p.G488E|STK31_ENST00000355870.3_Missense_Mutation_p.G488E|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Missense_Mutation_p.G465E	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	488							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GCCAAAGAAGGAGCAAATTCT	0.358000													41	120					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54792345	54792345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54792345G>A	ENST00000545554.1	+	20	5129	c.5129G>A	c.(5128-5130)gGa>gAa	p.G1710E	UNC13C_ENST00000537900.1_Missense_Mutation_p.G1708E|UNC13C_ENST00000260323.11_Missense_Mutation_p.G1710E			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1710	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTCCTTCATGGAGCACTGGGA	0.353000													6	24					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159174755	159174755	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159174755G>A	ENST00000537147.1	+	2	849	c.6G>A	c.(4-6)ggG>ggA	p.G2G	DARC_ENST00000368122.2_Silent_p.G2G			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	2					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					GTGCCATGGGGAACTGTCTGC	0.572000													25	70					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62632583	62632583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62632583C>T	ENST00000535781.1	+	9	1288	c.1177C>T	c.(1177-1179)Ctt>Ttt	p.L393F	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	393					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GAAGCGGGTTCTTCGGAAAGG	0.587000													23	39					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55184358	55184358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:55184358C>T	ENST00000337714.3	+	2	1766	c.1533C>T	c.(1531-1533)ttC>ttT	p.F511F	AKAP1_ENST00000539273.1_Silent_p.F511F|AKAP1_ENST00000572557.1_Silent_p.F511F|AKAP1_ENST00000571629.1_Silent_p.F511F|AKAP1_ENST00000314126.3_Silent_p.F511F	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	511					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					CAGATTCTTTCAGCACTTCAG	0.567000													68	185					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326001	152326001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152326001C>T	ENST00000388718.5	-	3	4333	c.4261G>A	c.(4261-4263)Gga>Aga	p.G1421R	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1421							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCCAGATCCCCTTCTTCCA	0.527000													139	340					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77376986	77376986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77376986C>T	ENST00000451710.3	-	26	4838	c.4601G>A	c.(4600-4602)aGg>aAg	p.R1534K	TRPM6_ENST00000376864.4_Missense_Mutation_p.R1534K|TRPM6_ENST00000449912.2_Missense_Mutation_p.R1529K|TRPM6_ENST00000360774.1_Missense_Mutation_p.R1534K|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.R1529K|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1534					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AGCGAAGGGCCTGTATCTGCG	0.413000													13	75					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784321	9784321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9784321G>A	ENST00000304374.2	+	1	1064	c.668G>A	c.(667-669)cGa>cAa	p.R223Q		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	223					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.R223Q(1)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	AGCCTGAATCGAACCTACGCC	0.582000													31	91					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113170685	113170685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113170685G>A	ENST00000401783.2	-	38	7531	c.7195C>T	c.(7195-7197)Cat>Tat	p.H2399Y	SVEP1_ENST00000374469.1_Missense_Mutation_p.H2376Y|SVEP1_ENST00000297826.5_Missense_Mutation_p.H325Y	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2399	Sushi 17.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTTCCAAAATGAAGAGCAGAA	0.458000													9	26					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13823467	13823467	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13823467C>T	ENST00000265104.4	-	40	6696	c.6592G>A	c.(6592-6594)Gaa>Aaa	p.E2198K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2198					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AACAAGGGTTCATCCTCATCA	0.368000									Kartagener syndrome				27	89					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86277262	86277262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:86277262G>A	ENST00000314673.3	-	5	627	c.451C>T	c.(451-453)Ccg>Tcg	p.P151S	SNX14_ENST00000369627.2_Missense_Mutation_p.P151S|SNX14_ENST00000346348.3_Intron|SNX14_ENST00000508980.1_5'UTR|RP11-321N4.5_ENST00000503906.1_3'UTR|SNX14_ENST00000505648.1_Missense_Mutation_p.P99S|SNX14_ENST00000513865.1_Missense_Mutation_p.P151S	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	151	PXA.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CTGTACCACGGATAAACAAAG	0.274000													21	60					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111145995	111145995	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111145995C>T	ENST00000485317.1	-	3	2083	c.1410G>A	c.(1408-1410)gaG>gaA	p.E470E	KCNA2_ENST00000316361.4_Silent_p.E470E|KCNA2_ENST00000369770.3_Intron|KCNA2_ENST00000440270.1_Silent_p.E470E			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	470						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CTCTAAAGTCCTCATTACTGT	0.388000													21	131					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541680	133541680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133541680C>T	ENST00000409261.1	-	14	3077	c.2704G>A	c.(2704-2706)Gag>Aag	p.E902K	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.E902K	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	902							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TCACTAGACTCAATGGCAGGC	0.647000													18	55					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44250212	44250212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44250212C>T	ENST00000371505.4	-	4	1053	c.931G>A	c.(931-933)Gag>Aag	p.E311K	TMEM151B_ENST00000438774.2_Intron|TCTE1_ENST00000371503.3_Intron|TCTE1_ENST00000371504.1_Intron	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	311										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AAGTCCAGCTCCTCGAGGACT	0.567000													8	96					0	0	1	0	0
MEDAG	84935	broad.mit.edu	37	13	31495738	31495738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:31495738G>A	ENST00000380482.4	+	4	867	c.542G>A	c.(541-543)gGa>gAa	p.G181E	TEX26-AS1_ENST00000588726.1_RNA|TEX26-AS1_ENST00000586464.1_RNA|TEX26-AS1_ENST00000586973.1_RNA|TEX26-AS1_ENST00000590721.1_RNA|TEX26-AS1_ENST00000590344.1_RNA|TEX26-AS1_ENST00000593246.1_RNA|TEX26-AS1_ENST00000451495.2_RNA|TEX26-AS1_ENST00000592950.1_RNA|TEX26-AS1_ENST00000585870.1_RNA	NM_032849.3	NP_116238.2			mesenteric estrogen-dependent adipogenesis																		TTCCCCCCAGGAAATGAAGTG	0.358000													33	77					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72146332	72146332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72146332C>T	ENST00000268482.3	+	27	4129	c.3620C>T	c.(3619-3621)cCa>cTa	p.P1207L	DHX38_ENST00000536867.1_Missense_Mutation_p.P519L|PMFBP1_ENST00000537792.1_3'UTR	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1207					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				ATCTACACTCCAGGCCGGAAA	0.627000													42	74					0	0	1	0	0
NCAM2	4685	broad.mit.edu	37	21	22790820	22790820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:22790820G>A	ENST00000400546.1	+	11	1660	c.1411G>A	c.(1411-1413)Gga>Aga	p.G471R	NCAM2_ENST00000284894.7_Missense_Mutation_p.G329R	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	471	Ig-like C2-type 5.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CAATGACTTTGGACGCTATAA	0.318000													19	162					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109365066	109365066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109365066C>T	ENST00000356711.2	+	3	410	c.284C>T	c.(283-285)tCc>tTc	p.S95F	MYO16_ENST00000251041.5_Missense_Mutation_p.S95F|MYO16_ENST00000357550.2_Missense_Mutation_p.S95F	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	95					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCGGGAGGGTCCCTGCTCCAT	0.562000													36	95					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263316	248263316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248263316C>T	ENST00000366478.2	+	3	976	c.639C>T	c.(637-639)atC>atT	p.I213I	OR2L13_ENST00000358120.2_Silent_p.I213I	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TCATTGGCATCACTTCTTCCT	0.428000													26	82					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102965001	102965001	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:102965001C>T	ENST00000504592.1	+	15	2279	c.1861C>T	c.(1861-1863)Caa>Taa	p.Q621*	BANK1_ENST00000322953.4_Nonsense_Mutation_p.Q636*|BANK1_ENST00000508653.1_Nonsense_Mutation_p.Q503*|BANK1_ENST00000428908.1_Nonsense_Mutation_p.Q503*|BANK1_ENST00000444316.2_Nonsense_Mutation_p.Q606*			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	636					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TACAGTGTTTCAACAAAAGAC	0.328000													73	153					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196619103	196619103	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196619103C>T	ENST00000312428.6	-	63	11822	c.11722G>A	c.(11722-11724)Gaa>Aaa	p.E3908K	DNAH7_ENST00000409063.1_Missense_Mutation_p.E391K	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3908					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCATCACTTCATAGTCAAAC	0.463000													11	80					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739229	55739229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55739229G>A	ENST00000370830.3	-	1	1133	c.435C>T	c.(433-435)ctC>ctT	p.L145L	BMP5_ENST00000446683.2_Silent_p.L145L	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	145					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TGGTATCATGGAGGCTGGCTA	0.453000													22	107					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213872121	213872121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:213872121G>A	ENST00000457361.1	-	8	1712	c.1544C>T	c.(1543-1545)tCa>tTa	p.S515L	IKZF2_ENST00000374327.4_Missense_Mutation_p.S370L|IKZF2_ENST00000342002.2_Missense_Mutation_p.S521L|IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000374319.4_Missense_Mutation_p.S489L|IKZF2_ENST00000421754.2_Missense_Mutation_p.S441L|IKZF2_ENST00000434687.1_Missense_Mutation_p.S515L|IKZF2_ENST00000451136.2_Missense_Mutation_p.S443L	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		AATGTGTGATGAAAACTCATA	0.483000													25	105					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160710199	160710199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160710199C>T	ENST00000263636.4	-	19	2632	c.2605G>A	c.(2605-2607)Gat>Aat	p.D869N	LY75-CD302_ENST00000505052.1_Missense_Mutation_p.D869N|LY75_ENST00000553424.1_Missense_Mutation_p.D869N|LY75_ENST00000554112.1_Missense_Mutation_p.D869N|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.D869N	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TTCTGTCCATCACCAGATATC	0.363000													48	118					0	0	1	0	0
BHMT2	23743	broad.mit.edu	37	5	78376586	78376586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78376586G>A	ENST00000255192.3	+	4	401	c.335G>A	c.(334-336)gGg>gAg	p.G112E	DMGDH_ENST00000520388.1_Intron|BHMT2_ENST00000521567.1_Intron	NM_017614.4	NP_060084.2	Q9H2M3	BHMT2_HUMAN	betaine--homocysteine S-methyltransferase 2	112	Hcy-binding.				methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	15		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	GTAGCAGGGGGGATCTGCCAG	0.453000													35	97					0	0	1	0	0
TSHB	7252	broad.mit.edu	37	1	115576077	115576077	+	Missense_Mutation	SNP	G	G	A	rs121918669		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115576077G>A	ENST00000256592.1	+	2	162	c.94G>A	c.(94-96)Gaa>Aaa	p.E32K	TSHB_ENST00000369517.1_Missense_Mutation_p.E32K	NM_000549.3|NM_001277991.1	NP_000540.2|NP_001264920.1	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta	32					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity	p.E32K(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		AATGCACATCGAAAGGAGAGA	0.423000													42	139					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31302378	31302378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31302378C>T	ENST00000265071.2	+	6	1237	c.972C>T	c.(970-972)acC>acT	p.T324T	CDH6_ENST00000514738.1_Silent_p.T269T	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	324	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ACCAGGAAACCCAGGAAGGGA	0.463000													18	50					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136562369	136562369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136562369C>T	ENST00000264162.2	-	10	4442	c.4432G>A	c.(4432-4434)Gat>Aat	p.D1478N		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1478	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGCAGTGTATCGATGAGCCTC	0.587000													13	34					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38774898	38774898	+	Nonsense_Mutation	SNP	G	G	A	rs145139818	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:38774898G>A	ENST00000308973.4	-	4	2919	c.2314C>T	c.(2314-2316)Cga>Tga	p.R772*	TLR10_ENST00000506111.1_Nonsense_Mutation_p.R772*|TLR10_ENST00000508334.1_Nonsense_Mutation_p.R772*|TLR10_ENST00000361424.2_Nonsense_Mutation_p.R772*	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	772	TIR.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						ATAGCAGCTCGAAGGTTTGCC	0.418000													33	97					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595313	55595313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55595313G>A	ENST00000378397.1	+	1	619	c.619G>A	c.(619-621)Gag>Aag	p.E207K		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				CACTTTGAATGAGAGTGTTAC	0.473000										HNSCC(27;0.073)			60	155					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149274851	149274851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149274851G>A	ENST00000255266.5	-	13	1742	c.1623C>T	c.(1621-1623)gcC>gcT	p.A541A		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	541					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ACCGCACCAGGGCCTGTGAAC	0.542000													23	67					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52522226	52522226	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52522226C>T	ENST00000345716.4	+	16	2852	c.2718C>T	c.(2716-2718)atC>atT	p.I906I	NISCH_ENST00000479054.1_Silent_p.I906I	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	906					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CCGCCGCCATCCCCTACTGGC	0.642000													21	68					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735935	41735935	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41735935C>T	ENST00000352645.4	+	10	1189	c.932C>T	c.(931-933)cCt>cTt	p.P311L	ZC3H7B_ENST00000351589.4_Missense_Mutation_p.P311L	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	327					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						GGCTCCATCCCTGTCTCCAGC	0.692000													37	57					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124045738	124045738	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124045738G>C	ENST00000368994.2	+	5	614	c.363G>C	c.(361-363)ctG>ctC	p.L121L	BTBD16_ENST00000260723.4_Silent_p.L120L			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	120										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CACACCCCCTGAGGGAGCTGG	0.602000													35	96					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14852240	14852240	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14852240C>T	ENST00000358984.4	+	36	4120	c.3940C>T	c.(3940-3942)Cga>Tga	p.R1314*		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1399										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TAGGTGGCTTCGACAGCAATT	0.348000													3	4					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111936872	111936872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111936872C>T	ENST00000374566.3	-	26	3182	c.2665G>A	c.(2665-2667)Gag>Aag	p.E889K		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	889						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ATCATCTTCTCTCTCTCCAGT	0.448000													5	53					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42718224	42718224	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:42718224G>A	ENST00000230882.4	+	9	1135		c.e9+1		GHR_ENST00000513625.1_Splice_Site|GHR_ENST00000357703.3_Splice_Site|GHR_ENST00000537449.1_Splice_Site	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor						2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TCTCCTCAAGGTAACTAATAA	0.328000													29	66					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71549884	71549884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71549884C>T	ENST00000265382.3	+	13	1585	c.1280C>T	c.(1279-1281)tCa>tTa	p.S427L	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.S427L	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	427						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		ATTGTGTCCTCAATTAGCCAG	0.433000													20	73					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182780880	182780880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182780880C>T	ENST00000431877.2	+	11	2692	c.2513C>T	c.(2512-2514)cCa>cTa	p.P838L	SSFA2_ENST00000409136.1_Missense_Mutation_p.P347L|SSFA2_ENST00000409001.1_Missense_Mutation_p.P838L|SSFA2_ENST00000428267.2_Missense_Mutation_p.P685L|SSFA2_ENST00000320370.7_Missense_Mutation_p.P838L	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	838						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			GCTCCACCACCAATGTCTCAG	0.547000													32	98					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6521698	6521698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6521698G>A	ENST00000377782.3	-	10	1144	c.1077C>T	c.(1075-1077)ttC>ttT	p.F359F	TNFRSF25_ENST00000348333.3_Silent_p.F305F|TNFRSF25_ENST00000356876.3_Silent_p.F350F|TNFRSF25_ENST00000351748.3_Silent_p.F167F|TNFRSF25_ENST00000351959.5_Silent_p.F313F	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	350	Death.				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GCGTGCGCACGAACTCCTTCC	0.697000													7	21					0	0	1	0	0
SLC25A24	29957	broad.mit.edu	37	1	108735132	108735132	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:108735132G>A	ENST00000370041.4	-	1	308	c.112C>T	c.(112-114)Cta>Tta	p.L38L	SLC25A24_ENST00000565488.1_Intron	NM_213651.2	NP_998816.1	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	57	EF-hand 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		GCTTCCTCTAGAGATTGAATG	0.522000													108	238					0	0	1	0	0
SULT1E1	6783	broad.mit.edu	37	4	70713498	70713498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70713498G>A	ENST00000226444.3	-	6	621	c.509C>T	c.(508-510)tCc>tTc	p.S170F		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	170					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						TTTATACCAGGAACCATAAGG	0.368000													25	83					0	0	1	0	0
GJC3	349149	broad.mit.edu	37	7	99526588	99526588	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99526588C>T	ENST00000312891.2	-	1	655	c.656G>A	c.(655-657)tGg>tAg	p.W219*		NM_181538.2	NP_853516.1	Q8NFK1	CXG3_HUMAN	gap junction protein, gamma 3, 30.2kDa	219						connexon complex|integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	9	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CCAGGTCCTCCACCATCTCCC	0.458000													24	53					0	0	1	0	0
GFI1	2672	broad.mit.edu	37	1	92948963	92948963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92948963G>A	ENST00000370332.1	-	2	400	c.82C>T	c.(82-84)Cgt>Tgt	p.R28C	GFI1_ENST00000294702.5_Missense_Mutation_p.R28C|GFI1_ENST00000427103.1_Missense_Mutation_p.R28C|GFI1_ENST00000483490.1_5'UTR	NM_001127215.1	NP_001120687.1	Q99684	GFI1_HUMAN	growth factor independent 1 transcription repressor	28					negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		TTCTCTAAACGGAGGGAATAG	0.647000													4	26					0	0	1	0	0
MFAP3L	9848	broad.mit.edu	37	4	170912825	170912825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:170912825G>A	ENST00000361618.3	-	3	1241	c.934C>T	c.(934-936)Cct>Tct	p.P312S	MFAP3L_ENST00000393704.3_Missense_Mutation_p.P209S|RP11-6E9.4_ENST00000508955.1_RNA	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	312						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		ATTTGCTGAGGTTGCTCGTGC	0.552000													5	49					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197404312	197404312	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197404312C>T	ENST00000367397.1	+	5	2320	c.1462C>T	c.(1462-1464)Ctc>Ttc	p.L488F	CRB1_ENST00000535699.1_Missense_Mutation_p.L1083F|CRB1_ENST00000367400.3_Missense_Mutation_p.L1107F|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000544212.1_Missense_Mutation_p.L588F|CRB1_ENST00000367399.2_Missense_Mutation_p.L995F			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1107	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGGCATTTATCTCTCTTACTT	0.368000													28	97					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41496173	41496173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41496173C>T	ENST00000400454.1	-	20	4122	c.3645G>A	c.(3643-3645)ctG>ctA	p.L1215L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1215	Fibronectin type-III 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGATGCCGTTCAGCTTGAGAG	0.567000													23	156					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117691541	117691541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117691541G>A	ENST00000317775.6	-	17	3235	c.2550C>T	c.(2548-2550)ttC>ttT	p.F850F	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.F884F	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	850	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGACGCTGTTGAATCGGACCT	0.542000													10	69					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284448	159284448	+	Splice_Site	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159284448A>C	ENST00000332217.5	-	1	1	c.0_splice	c.e1-1	p.M1_splice		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					TAGCTTTGGCATCAAGGTAGG	0.423000													40	173					0	0	1	0	0
KRT39	390792	broad.mit.edu	37	17	39118816	39118816	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39118816C>T	ENST00000355612.2	-	4	744		c.e4-1		AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39							intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				AATTGATTTCCTAAGGAAAGA	0.403000													34	73					0	0	1	0	0
UPK3B	80761	broad.mit.edu	37	7	76140314	76140314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76140314C>T	ENST00000419923.2	+	1	570	c.345C>T	c.(343-345)ttC>ttT	p.F115F	UPK3B_ENST00000448265.3_Silent_p.F115F|UPK3B_ENST00000443097.2_Silent_p.F60F|UPK3B_ENST00000257632.5_Silent_p.F115F|UPK3B_ENST00000394849.1_Silent_p.F60F|UPK3B_ENST00000334348.3_Silent_p.F60F			Q9BT76	UPK3B_HUMAN	uroplakin 3B	115					negative regulation of gene expression	integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(1)|skin(2)	8		Myeloproliferative disorder(862;0.204)				GCTGTGTCTTCGATGGGCTTG	0.632000													5	4					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130504133	130504133	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130504133C>T	ENST00000314830.8	-	9	2135	c.2022G>A	c.(2020-2022)gaG>gaA	p.E674E	SH2D3C_ENST00000429553.1_Silent_p.E320E|SH2D3C_ENST00000373274.3_Silent_p.E514E|SH2D3C_ENST00000420366.1_Silent_p.E516E|SH2D3C_ENST00000373277.4_Silent_p.E517E|SH2D3C_ENST00000373276.3_Silent_p.E606E	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	674	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCCCCCGCAGCTCGGCCGCCA	0.662000													27	42					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118147626	118147626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:118147626C>T	ENST00000456015.2	+	1	60	c.60C>T	c.(58-60)ttC>ttT	p.F20F	SLC30A8_ENST00000427715.2_5'UTR|SLC30A8_ENST00000521243.1_Intron|SLC30A8_ENST00000521035.1_3'UTR|SLC30A8_ENST00000519688.1_5'UTR	NM_173851.2	NP_776250.2	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	20					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TGTATGCTTTCACACTAGAAA	0.403000													40	152					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219884425	219884425	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219884425C>T	ENST00000341552.5	-	20	3359	c.3276G>A	c.(3274-3276)gaG>gaA	p.E1092E	CCDC108_ENST00000441968.1_Silent_p.E1092E|CCDC108_ENST00000453220.1_Silent_p.E1092E	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1092						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTCCTGCTTCTCCCCAGCCT	0.622000													6	27					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21876620	21876620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21876620G>A	ENST00000399982.2	-	12	2645	c.2581C>T	c.(2581-2583)Ccc>Tcc	p.P861S	CHD8_ENST00000557364.1_Missense_Mutation_p.P861S|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Missense_Mutation_p.P582S	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	861	Helicase ATP-binding.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ACCAAGAAGGGACCATGGATG	0.468000													11	76					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012823	29012823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29012823C>T	ENST00000377175.1	-	1	194	c.130G>A	c.(130-132)Gcc>Acc	p.A44T		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						AGAATGATGGCTGTGTTACCC	0.403000													48	102					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616431	248616431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248616431G>A	ENST00000342927.3	+	1	355	c.333G>A	c.(331-333)ggG>ggA	p.G111G		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGATTGGAGGGGAATTCTTCC	0.542000													45	244					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10032366	10032366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:10032366C>T	ENST00000378380.3	+	7	2028	c.1699C>T	c.(1699-1701)Cat>Tat	p.H567Y	SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000488991.1_3'UTR|ANKEF1_ENST00000378392.1_Missense_Mutation_p.H567Y|SNAP25-AS1_ENST00000603542.1_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		TTTTGCATGCCATGCAGGCCA	0.368000													18	68					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19070842	19070842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19070842C>T	ENST00000569532.1	+	15	2262	c.2132C>T	c.(2131-2133)tCa>tTa	p.S711L	TMC7_ENST00000421369.3_Intron|TMC7_ENST00000304381.5_Intron			Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	0						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						TCCAGAGGGTCATGGCTGGGG	0.517000													22	48					0	0	1	0	0
PIK3R1	5295	broad.mit.edu	37	5	67576471	67576471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:67576471C>T	ENST00000521381.1	+	6	1366	c.750C>T	c.(748-750)ctC>ctT	p.L250L	PIK3R1_ENST00000521657.1_Silent_p.L250L|PIK3R1_ENST00000274335.5_Silent_p.L250L|PIK3R1_ENST00000396611.1_Silent_p.L250L	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	250	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TCTTCAAGCTCTCTCAAACCT	0.388000			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			55	151					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104472813	104472813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104472813C>T	ENST00000409874.4	+	16	1849	c.1801C>T	c.(1801-1803)Ctt>Ttt	p.L601F	TDRD9_ENST00000339063.5_Missense_Mutation_p.L601F	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	601					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				TTTAGCCCAACTTCCTGTAAA	0.378000													28	64					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36117840	36117840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36117840G>A	ENST00000296603.4	-	10	1761	c.1299C>T	c.(1297-1299)atC>atT	p.I433I		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	433						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AACTGACCTCGATATAAATAT	0.333000													14	24					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59189838	59189838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59189838C>T	ENST00000302040.4	-	1	611	c.589G>A	c.(589-591)Gag>Aag	p.E197K		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						GTCACCACCTCGCTGGTGAAG	0.478000													32	46					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11344004	11344004	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11344004G>A	ENST00000294618.7	-	22	2604	c.2593C>T	c.(2593-2595)Cgt>Tgt	p.R865C	DOCK6_ENST00000319867.7_Missense_Mutation_p.R169C	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	865					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CCAGAGCCACGGGCCAGTGTG	0.642000													11	30					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7329010	7329010	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7329010G>A	ENST00000333870.3	+	1	77	c.3G>A	c.(1-3)atG>atA	p.M1I	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_Start_Codon_SNP_p.M1I	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	1						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				CCCCCTCCATGGAAAACCAGC	0.607000													7	62					0	0	1	0	0
ODF1	4956	broad.mit.edu	37	8	103564014	103564014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:103564014G>A	ENST00000285402.3	+	1	215	c.59G>A	c.(58-60)aGa>aAa	p.R20K		NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	20					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			AAGGTGGACAGAGAACTAAGG	0.483000													14	119					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207564458	207564458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207564458C>T	ENST00000452335.2	-	7	828	c.712G>A	c.(712-714)Gga>Aga	p.G238R	DYTN_ENST00000477734.1_5'UTR	NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	238						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TACCTGAGTCCCGTGATTGGG	0.527000													4	42					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128478853	128478853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128478853G>A	ENST00000325888.8	+	8	1668	c.1407G>A	c.(1405-1407)tcG>tcA	p.S469S	FLNC_ENST00000346177.6_Silent_p.S469S	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	469					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TCCATGTGTCGGAAGGTAAGG	0.637000													30	60					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013088	107013088	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107013088G>A	ENST00000390625.2	-	0	286																											TGCTTCTAATGAAACCTACCC	0.507000													40	99					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101018320	101018320	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101018320T>A	ENST00000360863.6	-	16	2573	c.2379A>T	c.(2377-2379)gaA>gaT	p.E793D	RGS22_ENST00000519421.1_5'UTR|RGS22_ENST00000523437.1_Missense_Mutation_p.E781D|RGS22_ENST00000523287.1_Missense_Mutation_p.E612D	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	793					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ACTGTCGAGTTTCTTCCACCA	0.373000													18	47					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66254783	66254783	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66254783C>T	ENST00000532677.1	+	5	1001	c.600C>T	c.(598-600)gcC>gcT	p.A200A	DPP3_ENST00000541961.1_Silent_p.A181A|DPP3_ENST00000360510.2_Silent_p.A181A|DPP3_ENST00000531863.1_Silent_p.A201A|DPP3_ENST00000453114.1_Silent_p.A181A|DPP3_ENST00000530165.1_Silent_p.A151A	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	181					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TGGAAGATGCCAAATTGGCCC	0.542000													20	62					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56030715	56030715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56030715C>T	ENST00000309675.2	+	1	72	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						TGAATTCCTCCTTCTGGGATT	0.522000													42	88					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1441598	1441598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1441598G>A	ENST00000270349.9	-	3	421	c.294C>T	c.(292-294)ttC>ttT	p.F98F	SLC6A3_ENST00000453492.2_Silent_p.F98F	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	98					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGGGGACCAGGAAGGCACCTG	0.597000													13	36					0	0	1	0	0
TMEM61	199964	broad.mit.edu	37	1	55457675	55457675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55457675G>A	ENST00000371268.3	+	3	806	c.532G>A	c.(532-534)Gag>Aag	p.E178K	RP11-12C17.2_ENST00000436960.1_RNA	NM_182532.1	NP_872338.1	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	178						integral to membrane				endometrium(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	4						ACCCAGCTATGAGAGCATCAG	0.622000													17	131					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179520386	179520386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179520386C>T	ENST00000367615.4	-	8	1142	c.1074G>A	c.(1072-1074)caG>caA	p.Q358Q	NPHS2_ENST00000367616.4_Silent_p.Q290Q|AXDND1_ENST00000367618.3_Intron	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	358					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GGAGGCTTCCCTGAGTTCTGT	0.478000													34	92					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953566	140953566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140953566G>A	ENST00000277549.5	+	31	4666	c.2097G>A	c.(2095-2097)ctG>ctA	p.L699L	CACNA1B_ENST00000277551.2_Silent_p.L1503L|CACNA1B_ENST00000371372.1_Silent_p.L1503L|CACNA1B_ENST00000371363.1_Silent_p.L1503L|CACNA1B_ENST00000371355.4_Silent_p.L1504L|CACNA1B_ENST00000371357.1_Silent_p.L1504L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1503					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGCTGATGCTGAAATGCCTGA	0.542000													6	18					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39782184	39782184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:39782184C>T	ENST00000564288.1	+	28	4348	c.3571C>T	c.(3571-3573)Cat>Tat	p.H1191Y	MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000567887.1_Missense_Mutation_p.H1228Y|MACF1_ENST00000361689.2_Missense_Mutation_p.H1196Y|MACF1_ENST00000539005.1_Missense_Mutation_p.H1196Y|MACF1_ENST00000372915.3_Missense_Mutation_p.H1196Y|MACF1_ENST00000317713.7_Missense_Mutation_p.H1196Y|MACF1_ENST00000545844.1_Missense_Mutation_p.H1196Y			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	1196					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCTGGAGGCCCATTGGTCGAC	0.443000													43	120					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144995895	144995895	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144995895G>A	ENST00000322810.4	-	32	8674	c.8505C>T	c.(8503-8505)atC>atT	p.I2835I	PLEC_ENST00000354589.3_Silent_p.I2698I|PLEC_ENST00000357649.2_Silent_p.I2702I|PLEC_ENST00000527096.1_Silent_p.I2721I|PLEC_ENST00000356346.3_Silent_p.I2684I|PLEC_ENST00000354958.2_Silent_p.I2676I|PLEC_ENST00000345136.3_Silent_p.I2698I|PLEC_ENST00000436759.2_Silent_p.I2725I|PLEC_ENST00000398774.2_Silent_p.I2666I	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2835	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ACAGCCCTGCGATACTGCTGC	0.672000													11	42					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36130328	36130328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36130328G>A	ENST00000303965.4	-	21	3956	c.3467C>T	c.(3466-3468)cCt>cTt	p.P1156L		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1156	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TATATGCAAAGGATCACCATT	0.328000													16	55					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2436319	2436319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2436319C>T	ENST00000419816.2	+	22	4192	c.3918C>T	c.(3916-3918)ctC>ctT	p.L1306L	PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000378486.3_Silent_p.L1306L|PLCH2_ENST00000449969.1_3'UTR|PLCH2_ENST00000378488.3_Silent_p.L1270L			O75038	PLCH2_HUMAN	phospholipase C, eta 2	1306					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TGCGCTGGCTCACTGTCTTCC	0.711000													7	9					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110882722	110882722	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110882722A>G	ENST00000369784.3	+	1	1595	c.695A>G	c.(694-696)aAg>aGg	p.K232R	RBM15_ENST00000487146.2_Missense_Mutation_p.K232R|RBM15_ENST00000602849.1_Missense_Mutation_p.K232R	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	232	RRM 1.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGGGCGGCCAAGCATGCCAGA	0.597000			T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	73					0	0	1	0	0
PCIF1	63935	broad.mit.edu	37	20	44569769	44569769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44569769C>T	ENST00000372409.3	+	7	960	c.596C>T	c.(595-597)cCc>cTc	p.P199L		NM_022104.3	NP_071387.1	Q9H4Z3	PCIF1_HUMAN	PDX1 C-terminal inhibiting factor 1	199						nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	20						CCCCCGCATCCCGAAGTGGAA	0.622000													18	45					0	0	1	0	0
BEST4	266675	broad.mit.edu	37	1	45250845	45250845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:45250845C>T	ENST00000372207.3	-	6	846	c.847G>A	c.(847-849)Gac>Aac	p.D283N		NM_153274.2	NP_695006.1	Q8NFU0	BEST4_HUMAN	bestrophin 4	283						chloride channel complex|plasma membrane	chloride channel activity			large_intestine(1)|lung(4)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)					ATGTCCGGGTCTCCCAGGGCT	0.627000													18	80					0	0	1	0	0
ETS2	2114	broad.mit.edu	37	21	40191557	40191557	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:40191557C>T	ENST00000360214.3	+	9	1402	c.942C>T	c.(940-942)ttC>ttT	p.F314F	ETS2_ENST00000360938.3_Silent_p.F314F	NM_001256295.1	NP_001243224.1	P15036	ETS2_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 2	314					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TCGAGAGCTTCGAAGATGACT	0.547000													14	34					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	97990571	97990571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97990571C>T	ENST00000224337.5	-	4	324	c.183G>A	c.(181-183)gaG>gaA	p.E61E	BLNK_ENST00000413476.2_Silent_p.E61E|BLNK_ENST00000427367.2_Silent_p.E61E|BLNK_ENST00000371176.2_Silent_p.E61E	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	61					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ACCACTGCTCCTCTTCGTCAG	0.542000													4	13					0	0	1	0	0
IGHV3-33	28434	broad.mit.edu	37	14	106815979	106815979	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106815979G>A	ENST00000390615.2	-	0	173																											CTCCCAGGCTGGACCACGCCT	0.577000													19	76					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6948775	6948775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:6948775C>T	ENST00000383032.1	+	14	1605	c.958C>T	c.(958-960)Ccc>Tcc	p.P320S	TBL1Y_ENST00000346432.3_Missense_Mutation_p.P320S|TBL1Y_ENST00000355162.2_Missense_Mutation_p.P320S	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	320					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						TGCTGCAGCCCCCGCCCTTGA	0.507000													28	21					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9018484	9018484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9018484G>A	ENST00000397910.4	-	24	37893	c.37690C>T	c.(37690-37692)Cct>Tct	p.P12564S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12566	SEA 4.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGGAGCCAGGGCGATGCATG	0.542000													49	151					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154158558	154158558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:154158558C>T	ENST00000360256.4	-	14	3707	c.3507G>A	c.(3505-3507)gtG>gtA	p.V1169V		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1169	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCCTACTACCACTTTGTTTT	0.403000													54	31					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474538	140474538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140474538G>A	ENST00000194155.4	+	1	312	c.164G>A	c.(163-165)gGg>gAg	p.G55E		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		55	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAGACCTGGGGCTGGAGATA	0.512000													14	64					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62739945	62739945	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62739945G>A	ENST00000371153.4	-	3	1209	c.831C>T	c.(829-831)ttC>ttT	p.F277F	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	277	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						AGCCAGGGGTGAACAACACCT	0.542000													13	15					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32954042	32954042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:32954042C>T	ENST00000321639.5	+	3	1022	c.694C>T	c.(694-696)Ccc>Tcc	p.P232S		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	232						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CTCCTCCTCGCCCTCCAGCCC	0.597000													13	49					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659194	196659194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196659194G>A	ENST00000312428.6	-	57	10684	c.10584C>T	c.(10582-10584)ttC>ttT	p.F3528F	DNAH7_ENST00000409063.1_Silent_p.F11F	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3528	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTGACACAGGGAAATTTGGAG	0.418000													41	98					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119027100	119027100	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119027100G>A	ENST00000307417.3	+	7	1112	c.748G>A	c.(748-750)Ggc>Agc	p.G250S	ABCG4_ENST00000449422.2_Missense_Mutation_p.G250S|ABCG4_ENST00000531739.1_Missense_Mutation_p.G250S	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	250	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGCACAGGGGGGCCGTACCAT	0.587000													66	163					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885060	29885060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29885060G>A	ENST00000310624.6	+	4	1464	c.1431G>A	c.(1429-1431)gaG>gaA	p.E477E		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	477	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						aggagaaagaggccaaagagg	0.507000													13	20					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25281188	25281188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25281188G>A	ENST00000218548.6	+	16	2548	c.2215G>A	c.(2215-2217)Gga>Aga	p.G739R	ATP12A_ENST00000381946.3_Missense_Mutation_p.G733R	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	733					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GACCGGGGATGGAGTTAATGA	0.557000													14	46					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37325588	37325588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:37325588G>A	ENST00000373091.3	-	6	833	c.817C>T	c.(817-819)Cgc>Tgc	p.R273C	GRIK3_ENST00000373093.4_Missense_Mutation_p.R273C	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	273					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCTGAGTAGCGGTAGGGCTCC	0.572000													17	73					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44685809	44685809	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44685809G>A	ENST00000454036.1	+	25	3271	c.3194_splice	c.e25-1	p.L1065_splice	SLC12A5_ENST00000243964.3_Splice_Site_p.L1042_splice	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	1065					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCTGCCGCAGGAACCAGTCCA	0.632000													11	62					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66937361	66937361	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:66937361C>T	ENST00000374690.3	+	5	2739	c.2215C>T	c.(2215-2217)Cag>Tag	p.Q739*	AR_ENST00000396043.2_Nonsense_Mutation_p.Q207*|AR_ENST00000396044.3_Intron	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	738	Interaction with MYST2.|Ligand-binding.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GGCTGTCATTCAGTACTCCTG	0.542000									Androgen Insensitivity Syndrome				17	13					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219664	67219664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67219664C>T	ENST00000312457.2	-	1	536	c.532G>A	c.(532-534)Gac>Aac	p.D178N		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	178						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			ATGACCAGGTCGTACCACCAG	0.662000													42	74					0	0	1	0	0
KRT34	3885	broad.mit.edu	37	17	39538306	39538306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39538306C>T	ENST00000394001.1	-	1	349	c.319G>A	c.(319-321)Gac>Aac	p.D107N		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	107	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				GCCAGGCGGTCGTTCAGGAAC	0.612000													17	109					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595213	55595213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55595213G>A	ENST00000378397.1	+	1	519	c.519G>A	c.(517-519)gtG>gtA	p.V173V		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V173V(1)		breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				GATCTAATGTGATTAACCACT	0.478000										HNSCC(27;0.073)			78	227					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147040970	147040970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147040970C>T	ENST00000265272.5	-	3	635	c.168G>A	c.(166-168)aaG>aaA	p.K56K	JAKMIP2_ENST00000333010.6_Silent_p.K14K|JAKMIP2_ENST00000507386.1_Silent_p.K56K	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	56						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGAATCCTCTTCGCTTCTT	0.507000													55	116					0	0	1	0	0
PCSK7	9159	broad.mit.edu	37	11	117100449	117100449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117100449G>A	ENST00000320934.3	-	3	742	c.112C>T	c.(112-114)Ctg>Ttg	p.L38L		NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	38					peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		GTCCCTGCCAGGCCCATGACC	0.652000			T	IGH@	MLCLS								11	29					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671187	31671187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31671187C>T	ENST00000375483.3	+	3	184	c.184C>T	c.(184-186)Ccc>Tcc	p.P62S		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	62						cytoplasm|extracellular region	lipid binding										TGGTGATATTCCCTACAATGA	0.507000													39	122					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177225145	177225145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177225145G>A	ENST00000361539.4	+	3	672	c.360G>A	c.(358-360)cgG>cgA	p.R120R		NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		120						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AGTTTATCCGGAACATTCGCC	0.483000											OREG0014006	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	79					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99661607	99661607	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:99661607G>A	ENST00000373034.4	-	1	3664	c.1989C>T	c.(1987-1989)tcC>tcT	p.S663S	PCDH19_ENST00000255531.7_Silent_p.S663S|PCDH19_ENST00000420881.2_Silent_p.S663S	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	663	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CGAGAGCAGGGGACAAGTAGA	0.522000													6	14					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1096345	1096345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1096345G>A	ENST00000441003.2	+	34	6397	c.6370G>A	c.(6370-6372)Gac>Aac	p.D2124N	MUC2_ENST00000361558.6_Missense_Mutation_p.D262N|MUC2_ENST00000333592.6_3'UTR	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4486						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGGCTGGGGCGACCCGCACTA	0.662000													10	38					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731166	21731166	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:21731166C>T	ENST00000584755.1	+	2	865	c.468C>T	c.(466-468)ttC>ttT	p.F156F	UBBP4_ENST00000578713.1_Silent_p.F156F|UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000583708.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						TGCAGATCTTCGTGAAGACCC	0.537000													28	34					0	0	1	0	0
DENND6A	201627	broad.mit.edu	37	3	57631445	57631445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:57631445G>A	ENST00000311128.5	-	11	1050	c.980C>T	c.(979-981)cCt>cTt	p.P327L	RP11-755B10.2_ENST00000470427.1_RNA	NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		AGTGAAATAAGGTCGGAAATC	0.338000													8	96					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11732253	11732253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:11732253C>T	ENST00000304623.8	-	2	358	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K	CTNND2_ENST00000458100.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.E57K	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	57					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TCTACCTGTTCTTTGACTGAG	0.418000													12	137					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16032807	16032807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16032807G>A	ENST00000350896.3	-	3	303	c.106C>T	c.(106-108)Cct>Tct	p.P36S	MSR1_ENST00000445506.2_Missense_Mutation_p.P54S|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000381998.4_Missense_Mutation_p.P36S|MSR1_ENST00000262101.5_Missense_Mutation_p.P36S|MSR1_ENST00000355282.2_Missense_Mutation_p.P36S	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	36					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CTGTTTTTAGGATCTAATAAA	0.388000													11	56					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30934539	30934539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30934539C>T	ENST00000355537.3	+	2	217	c.70C>T	c.(70-72)Ccc>Tcc	p.P24S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCTGAGTGGCCCCGTCCTCAA	0.622000													45	135					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67223019	67223019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67223019G>A	ENST00000314586.6	-	3	351	c.111C>T	c.(109-111)gcC>gcT	p.A37A	EXOC3L1_ENST00000562887.1_5'UTR	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	37	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						AGATGCCTGAGGCCCACTTGA	0.682000													5	14					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45945569	45945569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45945569C>T	ENST00000323084.4	-	8	1368	c.1303G>A	c.(1303-1305)Gag>Aag	p.E435K	TSPEAR_ENST00000397916.1_Missense_Mutation_p.E367K|C21orf90_ENST00000465978.1_Intron	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	435					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						AGGAAGTGCTCCCCATCCACC	0.592000													53	128					0	0	1	0	0
ADI1	55256	broad.mit.edu	37	2	3504690	3504690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:3504690G>A	ENST00000382093.5	-	3	3134	c.297C>T	c.(295-297)ttC>ttT	p.F99F	ADI1_ENST00000327435.6_Silent_p.F105F			Q9BV57	MTND_HUMAN	acireductone dioxygenase 1	105					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus|plasma membrane	acireductone dioxygenase (Ni2+-requiring) activity|metal ion binding|protein binding			breast(2)|large_intestine(2)|lung(4)|ovary(1)|stomach(1)	10	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0729)|Epithelial(75;0.173)|all cancers(51;0.228)		CCCTCACATCGAAGTACCCAC	0.537000													14	60					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50731719	50731719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:50731719C>T	ENST00000442544.2	+	10	2323	c.1707C>T	c.(1705-1707)tcC>tcT	p.S569S	DCC_ENST00000412726.1_Silent_p.S417S|DCC_ENST00000581580.1_Silent_p.S224S	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	569	Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTGAGGTGTCCACAGGAAAAG	0.473000													44	144					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81236166	81236166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81236166G>A	ENST00000599697.1	-	6	1081	c.1082C>T	c.(1081-1083)cCt>cTt	p.P361L	PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000337114.4_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	361					neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CTGGCAGAGAGGGCCGGCTCC	0.567000													12	88					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56047361	56047361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56047361G>A	ENST00000244728.5	-	2	453	c.56C>T	c.(55-57)tCt>tTt	p.S19F	COL21A1_ENST00000535941.1_Missense_Mutation_p.S19F|COL21A1_ENST00000370819.1_Missense_Mutation_p.S19F	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	19					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGCTAACACAGAATTCTGAAG	0.358000													7	16					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55961753	55961753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55961753G>A	ENST00000263923.4	-	20	3103	c.2808C>T	c.(2806-2808)gtC>gtT	p.V936V		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	936	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCTTGTAGGGGACAAATTCAT	0.423000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			22	64					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181732562	181732562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181732562C>T	ENST00000526775.1	+	33	4818	c.4653C>T	c.(4651-4653)ttC>ttT	p.F1551F	CACNA1E_ENST00000367567.4_Silent_p.F1177F|CACNA1E_ENST00000358338.5_Silent_p.F1502F|CACNA1E_ENST00000367570.1_Silent_p.F1570F|CACNA1E_ENST00000360108.3_Silent_p.F1551F|CACNA1E_ENST00000367573.2_Silent_p.F1570F|CACNA1E_ENST00000357570.5_Silent_p.F1521F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1570					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCAGTGGCTTCAATATGAGCT	0.433000													7	79					0	0	1	0	0
CHRM1	1128	broad.mit.edu	37	11	62677545	62677545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62677545G>A	ENST00000306960.3	-	2	1569	c.1028C>T	c.(1027-1029)cCc>cTc	p.P343L	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	343					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	CTTTCCACGGGGCTTCTGGCC	0.627000													14	41					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65500011	65500011	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65500011C>T	ENST00000261883.4	-	3	319	c.154_splice	c.e3+1	p.E51_splice		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	51					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						ACAACTCACTCTCCAGGGTGT	0.592000													27	25					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27167664	27167664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27167664C>T	ENST00000288699.6	+	12	1739	c.1581C>T	c.(1579-1581)gaC>gaT	p.D527D	DPYSL5_ENST00000401478.1_Silent_p.D527D	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	527					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCATGAGGGACCTTCACGAAT	0.622000													28	69					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55362421	55362421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:55362421C>T	ENST00000536015.1	-	10	1041	c.922G>A	c.(922-924)Ggc>Agc	p.G308S	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.G308S|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	308			G -> D (in BRIC1; dbSNP:rs28939685).|G -> V (in PFIC1; dbSNP:rs28939685).		ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				ATGACTAAGCCGTGGCAGAAA	0.383000													29	57					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75708675	75708675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75708675C>T	ENST00000370855.5	-	8	480	c.367G>A	c.(367-369)Gaa>Aaa	p.E123K	SLC44A5_ENST00000469525.1_5'UTR|SLC44A5_ENST00000535611.1_5'UTR|SLC44A5_ENST00000370859.3_Missense_Mutation_p.E123K	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	123						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						AAAAATTTTTCTGGGCACTTG	0.398000													7	106					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711218	140711218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140711218G>A	ENST00000517417.1	+	1	967	c.967G>A	c.(967-969)Gat>Aat	p.D323N	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.D323N	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAAGCCCAGGATGGTGCGGG	0.393000													25	73					0	0	1	0	0
MAN1A1	4121	broad.mit.edu	37	6	119623257	119623257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:119623257C>T	ENST00000368468.3	-	4	1153	c.712G>A	c.(712-714)Gga>Aga	p.G238R	MAN1A1_ENST00000368466.2_Missense_Mutation_p.G261R	NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	238					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		ATAGTTGCTCCTTTGATGTTA	0.289000													7	15					0	0	1	0	0
MIR31HG	554202	broad.mit.edu	37	9	21455665	21455665	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21455665C>A	ENST00000304425.3	-	0	720					NR_027054.1																						ACTTCAGATTCCCCCAGGAGA	0.502000													10	14					7.48243e-07	7.50121e-07	1	1	0
OR2L3	391192	broad.mit.edu	37	1	248224134	248224134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248224134G>A	ENST00000359959.3	+	1	151	c.151G>A	c.(151-153)Gac>Aac	p.D51N	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CATCTTCTTGGACACCCATCT	0.413000													159	416					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73479976	73479976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73479976G>A	ENST00000523207.1	+	2	595	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	3					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CAAAATGGCAGAAAAGGCTCC	0.512000													42	90					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64527540	64527540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64527540C>T	ENST00000498707.1	-	33	5513	c.5171G>A	c.(5170-5172)cGa>cAa	p.R1724Q	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.R1696Q	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1724	TSP type-1 15.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GCAGGTTTTTCGTTCTTCTGG	0.438000													36	128					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952916	54952916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54952916C>T	ENST00000273286.5	-	3	770	c.608G>A	c.(607-609)gGa>gAa	p.G203E	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.G127E|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000490478.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	203	LRRCT.					integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		GTCTGTTAGTCCCCCTTTAAA	0.453000													5	38					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151835975	151835975	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151835975G>A	ENST00000355193.2	-	59	14938	c.14720C>T	c.(14719-14721)tCg>tTg	p.S4907L	KMT2C_ENST00000262189.6_Missense_Mutation_p.S4850L|KMT2C_ENST00000485655.2_Missense_Mutation_p.S55L					lysine (K)-specific methyltransferase 2C																		AGGTGCACACGAATGGTTGAT	0.398000													32	118					0	0	1	0	0
PDK2	5164	broad.mit.edu	37	17	48182768	48182768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48182768C>T	ENST00000503176.1	+	3	455	c.294C>T	c.(292-294)ttC>ttT	p.F98F	PDK2_ENST00000007708.3_Silent_p.F34F	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	98					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						TCATGGAGTTCCTGGACAAGG	0.637000									Autosomal Dominant Polycystic Kidney Disease				10	23					0	0	1	0	0
PAOX	196743	broad.mit.edu	37	10	135193892	135193892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:135193892G>A	ENST00000278060.5	+	2	654	c.571G>A	c.(571-573)Gaa>Aaa	p.E191K	PAOX_ENST00000368535.2_3'UTR|PAOX_ENST00000368539.4_Intron|PAOX_ENST00000480071.2_Missense_Mutation_p.E191K|PAOX_ENST00000357296.3_Missense_Mutation_p.E191K	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	329					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		CTTCAACCTGGAATGCTGTGT	0.597000													8	36					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8602908	8602908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8602908C>T	ENST00000360986.4	+	3	354	c.180C>T	c.(178-180)acC>acT	p.T60T	CPZ_ENST00000506287.1_3'UTR|CPZ_ENST00000382480.2_5'UTR|CPZ_ENST00000315782.6_Silent_p.T49T	NM_001014447.2	NP_001014447.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	60	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACCACACCACCTTCCCCAACC	0.642000													16	49					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128489559	128489559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128489559C>T	ENST00000325888.8	+	30	5387	c.5126C>T	c.(5125-5127)cCc>cTc	p.P1709L	FLNC_ENST00000346177.6_Missense_Mutation_p.P1709L	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1709					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TACACAGCGCCCGAGCCGGGC	0.582000													25	42					0	0	1	0	0
CDSN	1041	broad.mit.edu	37	6	31084467	31084467	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31084467G>A	ENST00000376288.2	-	2	951	c.925C>T	c.(925-927)Cca>Tca	p.P309S	PSORS1C1_ENST00000259881.9_Intron|PSORS1C1_ENST00000467107.1_3'UTR	NM_001264.4	NP_001255.3	Q15517	CDSN_HUMAN	corneodesmosin	309	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)	10						GTCATGCCTGGAACCAGATAA	0.547000													6	61					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233388106	233388106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233388106C>T	ENST00000258229.8	-	7	2356	c.2122G>A	c.(2122-2124)Gaa>Aaa	p.E708K	PCNXL2_ENST00000430153.1_Missense_Mutation_p.E7K	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	708						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TCACCATGTTCATCAATGAAG	0.418000													18	54					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179535872	179535872	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179535872G>A	ENST00000589042.1	-	156	35477	c.35253C>T	c.(35251-35253)atC>atT	p.I11751I	TTN_ENST00000342992.6_Silent_p.I10450I|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.I11377I|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9869	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTGGAGGGATGATTTTCT	0.353000													14	37					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64824920	64824920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64824920C>T	ENST00000358658.3	-	4	553	c.526G>A	c.(526-528)Gag>Aag	p.E176K	NAALADL1_ENST00000339885.2_Missense_Mutation_p.E176K|NAALADL1_ENST00000356632.3_Missense_Mutation_p.E176K|NAALADL1_ENST00000340252.4_Missense_Mutation_p.E176K|NAALADL1_ENST00000355721.3_Intron|NAALADL1_ENST00000355369.2_Missense_Mutation_p.E176K	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	176					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						GTCTGTAGCTCCTTAAAGTCT	0.607000													22	49					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32752501	32752501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32752501C>T	ENST00000380250.3	+	21	3105	c.2609C>T	c.(2608-2610)cCc>cTc	p.P870L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AAGCACTGCCCCACAGCCCTC	0.562000													47	139					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21033937	21033937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21033937G>A	ENST00000381545.3	+	12	1699	c.1480G>A	c.(1480-1482)Ggt>Agt	p.G494S	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G494S|LST3_ENST00000540229.1_Missense_Mutation_p.G494S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.G494S|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	494	Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATCCTCAAGTGGTATTAAAAA	0.358000													47	119					0	0	1	0	0
GFRA2	2675	broad.mit.edu	37	8	21563492	21563492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:21563492G>A	ENST00000524240.1	-	5	1506	c.856C>T	c.(856-858)Cct>Tct	p.P286S	GFRA2_ENST00000517328.1_Missense_Mutation_p.P286S|GFRA2_ENST00000400782.4_Missense_Mutation_p.P181S|GFRA2_ENST00000518077.1_Missense_Mutation_p.P153S	NM_001495.4	NP_001486.4	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2	286						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|prostate(1)|skin(1)	7				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		TTGTCCGCAGGGCAGCTGGTG	0.587000													4	7					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39579060	39579060	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39579060C>T	ENST00000225550.3	-	3	701	c.702G>A	c.(700-702)gaG>gaA	p.E234E	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	234	Coil 1B.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				GGGAGAGCTGCTCCTCCTTCA	0.692000													18	22					0	0	1	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6527981	6527981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6527981G>A	ENST00000377748.1	-	21	3643	c.3146C>T	c.(3145-3147)cCc>cTc	p.P1049L	PLEKHG5_ENST00000400913.1_Missense_Mutation_p.P972L|PLEKHG5_ENST00000377732.1_Missense_Mutation_p.P1009L|PLEKHG5_ENST00000377728.3_Missense_Mutation_p.P972L|PLEKHG5_ENST00000377740.3_Intron|PLEKHG5_ENST00000535355.1_Missense_Mutation_p.P1041L|PLEKHG5_ENST00000377737.2_Missense_Mutation_p.P972L|PLEKHG5_ENST00000377725.1_Intron|PLEKHG5_ENST00000340850.5_Missense_Mutation_p.P972L|PLEKHG5_ENST00000544978.1_Intron|PLEKHG5_ENST00000537245.1_Missense_Mutation_p.P1051L|PLEKHG5_ENST00000400915.3_Missense_Mutation_p.P1028L	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	1028					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CCCTGGTGGGGGCTCAGGCTG	0.672000													5	8					0	0	1	0	0
BIVM-ERCC5	100533467	broad.mit.edu	37	13	103510682	103510682	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:103510682C>T	ENST00000602836.1	+	14	1862	c.1862C>T	c.(1861-1863)cCt>cTt	p.P621L	ERCC5_ENST00000535557.1_Silent_p.L196L|ERCC5_ENST00000355739.4_Silent_p.L196L	NM_001204425.1	NP_001191354.1	Q59FZ7	Q59FZ7_HUMAN		0					nucleotide-excision repair	nucleus	endonuclease activity|single-stranded DNA binding										CTTCAGCAGCCTGCCCCCTGA	0.388000													41	87					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190068213	190068213	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190068213C>T	ENST00000367462.3	-	8	1467	c.1236G>A	c.(1234-1236)gaG>gaA	p.E412E	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.E310E	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		412						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGAGGCCGTTCTCATTGCAGT	0.488000													13	27					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96790332	96790332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96790332G>A	ENST00000359933.4	-	16	3334	c.2441C>T	c.(2440-2442)tCg>tTg	p.S814L		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	814										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TTCCTGGAACGATCCTAAAAA	0.398000													12	43					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169696913	169696913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169696913C>T	ENST00000333360.7	-	9	1574	c.1435G>A	c.(1435-1437)Gga>Aga	p.G479R	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367775.1_Missense_Mutation_p.G354R|SELE_ENST00000367774.1_Intron|SELE_ENST00000367782.4_Intron|SELE_ENST00000367779.4_Intron|SELE_ENST00000367781.4_Missense_Mutation_p.G416R|SELE_ENST00000367777.1_Intron|SELE_ENST00000367776.1_Missense_Mutation_p.G416R|SELE_ENST00000367780.4_Missense_Mutation_p.G354R	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	479	Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					GTCCATTGTCCCTGAGATGTG	0.428000													30	118					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	134041097	134041097	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134041097C>T	ENST00000398844.2	+	17	2809	c.2521C>T	c.(2521-2523)Caa>Taa	p.Q841*		NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	841					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGCTGATGTTCAAGCAATTTC	0.353000													17	134					0	0	1	0	0
SDC4	6385	broad.mit.edu	37	20	43959189	43959189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43959189G>A	ENST00000372733.3	-	4	301	c.262C>T	c.(262-264)Cat>Tat	p.H88Y	SDC4_ENST00000537976.1_Missense_Mutation_p.H16Y	NM_002999.3	NP_002990.2	P31431	SDC4_HUMAN	syndecan 4	88						extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity		SDC4/ROS1(7)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)	5		Myeloproliferative disorder(115;0.0122)				TCAGGGATATGGTTATCTAGA	0.542000			T	ROS1	NSCLC								15	30					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35624433	35624433	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:35624433C>A	ENST00000287272.2	+	14	2140	c.2120C>A	c.(2119-2121)tCc>tAc	p.S707Y	UNC5D_ENST00000416672.1_Missense_Mutation_p.S781Y|UNC5D_ENST00000420357.1_Missense_Mutation_p.S709Y|UNC5D_ENST00000449677.1_Missense_Mutation_p.S352Y|UNC5D_ENST00000404895.2_Missense_Mutation_p.S776Y|UNC5D_ENST00000453357.2_Missense_Mutation_p.S771Y			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	776	Interaction with DCC (By similarity).				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GTCCCGTTCTCCCGCGTGTGG	0.562000													9	44					0.00621372	0.00621734	1	1	0
CELSR3	1951	broad.mit.edu	37	3	48684207	48684207	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48684207G>A	ENST00000544264.1	-	22	7579	c.7299C>T	c.(7297-7299)cgC>cgT	p.R2433R	CELSR3_ENST00000164024.4_Silent_p.R2428R			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2428					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGGCACCTCGGCGTTCTGCCT	0.597000													8	30					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73072163	73072163	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73072163G>A	ENST00000429829.1	-	0	425					NR_001564.2																						AGGTATCCACGGCCCCGTTGG	0.438000													8	4					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247151348	247151348	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247151348G>A	ENST00000339986.7	-	4	616	c.469C>T	c.(469-471)Caa>Taa	p.Q157*	ZNF695_ENST00000487338.2_Intron|ZNF695_ENST00000498046.2_Intron	NM_020394.4	NP_065127.4	Q8IW36	ZN695_HUMAN	zinc finger protein 695	157					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTATTGCATTGAAAGTTTTTG	0.358000													52	226					0	0	1	0	0
TNFRSF10C	8794	broad.mit.edu	37	8	22972217	22972217	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22972217G>A	ENST00000540813.1	+	0	309				TNFRSF10C_ENST00000520607.1_3'UTR|TNFRSF10C_ENST00000356864.3_Missense_Mutation_p.G72S			O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain						apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(6)|lung(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		GTGCACAGAGGGTGTGGATTA	0.478000													44	89					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73474369	73474369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73474369G>A	ENST00000252034.7	+	23	1967	c.1568G>A	c.(1567-1569)gGa>gAa	p.G523E	ELN_ENST00000380553.4_Missense_Mutation_p.G387E|ELN_ENST00000380562.4_Missense_Mutation_p.G529E|ELN_ENST00000358929.4_Missense_Mutation_p.G558E|ELN_ENST00000414324.1_Missense_Mutation_p.G499E|ELN_ENST00000320399.6_Missense_Mutation_p.G523E|ELN_ENST00000429192.1_Missense_Mutation_p.G509E|ELN_ENST00000380584.4_Missense_Mutation_p.G490E|CTB-51J22.1_ENST00000435932.1_RNA|ELN_ENST00000445912.1_Missense_Mutation_p.G523E|ELN_ENST00000458204.1_Missense_Mutation_p.G513E|ELN_ENST00000357036.5_Missense_Mutation_p.G528E|ELN_ENST00000380576.5_Missense_Mutation_p.G504E|ELN_ENST00000320492.7_Missense_Mutation_p.G442E|ELN_ENST00000380575.4_Missense_Mutation_p.G494E	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	552	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	GGCCCTGGTGGAGTTGCAGGT	0.642000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						10	113					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34400213	34400213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:34400213G>A	ENST00000374789.3	-	25	4280	c.3955C>T	c.(3955-3957)Ccc>Tcc	p.P1319S	PARD3_ENST00000374794.3_Missense_Mutation_p.P1207S|PARD3_ENST00000346874.4_Missense_Mutation_p.P1282S|PARD3_ENST00000374788.3_Missense_Mutation_p.P1316S|PARD3_ENST00000374790.3_Missense_Mutation_p.P1259S|PARD3_ENST00000350537.4_Missense_Mutation_p.P1273S|PARD3_ENST00000545693.1_Missense_Mutation_p.P1303S|PARD3_ENST00000545260.1_Missense_Mutation_p.P1229S	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1319					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				GCGTAACTGGGGTCCTGGACT	0.597000													15	61					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701623	56701623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56701623G>A	ENST00000586855.2	-	5	1374	c.1061C>T	c.(1060-1062)cCc>cTc	p.P354L	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.P354L			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	354					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ACATGCAAAGGGCGGCAGGGC	0.527000													29	82					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640889	3640889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3640889G>A	ENST00000294008.3	-	12	3390	c.2750C>T	c.(2749-2751)gCc>gTc	p.A917V		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	917	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CCAGGTGGTGGCGGCCTCATC	0.652000								Direct reversal of damage					29	117					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90119263	90119263	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90119263C>T	ENST00000405460.2	+	76	16314	c.16218C>T	c.(16216-16218)gtC>gtT	p.V5406V	GPR98_ENST00000425867.2_Silent_p.V1067V	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5406					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGTCAAGGTCTTTTGGCGAG	0.463000													24	59					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72992967	72992967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72992967G>A	ENST00000268489.5	-	2	1750	c.1078C>T	c.(1078-1080)Ccc>Tcc	p.P360S	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	360					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CTGTGTCCGGGGCCTATGAGG	0.522000													50	78					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5153839	5153839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5153839C>T	ENST00000252321.3	+	1	755	c.526C>T	c.(526-528)Ctc>Ttc	p.L176F		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	176						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						CGACGGTATCCTCTACTACTA	0.652000													8	73					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525760	176525760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176525760G>A	ENST00000367662.3	+	2	1466	c.302G>A	c.(301-303)gGa>gAa	p.G101E	PAPPA2_ENST00000367661.3_Missense_Mutation_p.G101E	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	101					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.G101E(2)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GACACTGAAGGAAATGCTGTG	0.567000													70	159					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440515	124440515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124440515C>T	ENST00000284287.3	+	1	623	c.551C>T	c.(550-552)cCc>cTc	p.P184L		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		TTAAAACTGCCCTATTGTGAG	0.483000													30	77					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21641163	21641163	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21641163C>T	ENST00000328843.6	+	18	3606	c.3575C>T	c.(3574-3576)cCt>cTt	p.P1192L	DNAH11_ENST00000409508.3_Missense_Mutation_p.P1192L			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1192	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CTCTTTGAACCTCTAAAAGAA	0.418000									Kartagener syndrome				5	35					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56350260	56350260	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56350260G>A	ENST00000340482.3	-	9	1913	c.1737C>T	c.(1735-1737)ctC>ctT	p.L579L	MPO_ENST00000225275.3_Silent_p.L547L			P05164	PERM_HUMAN	myeloperoxidase	547					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	TGAGGCCCCGGAGGATGGGGT	0.572000													59	182					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102900631	102900631	+	Missense_Mutation	SNP	C	C	T	rs150165045		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102900631C>T	ENST00000359520.7	+	9	1703	c.1477C>T	c.(1477-1479)Cct>Tct	p.P493S	TECPR2_ENST00000558678.1_Missense_Mutation_p.P493S	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	493							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CTCCGAATTTCCTGGGGACAG	0.507000													26	68					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936761	4936761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4936761G>A	ENST00000322013.3	-	1	161	c.133C>T	c.(133-135)Ccg>Tcg	p.P45S	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGTTGCCCGGGATGGAAACC	0.502000													17	79					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102036332	102036332	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102036332G>A	ENST00000549145.1	+	10	865	c.765G>A	c.(763-765)aaG>aaA	p.K255K	MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000361466.2_Silent_p.K267K|MYBPC1_ENST00000360610.2_Silent_p.K242K|MYBPC1_ENST00000550270.1_Silent_p.K242K|MYBPC1_ENST00000547509.1_Silent_p.K228K|MYBPC1_ENST00000547405.1_Silent_p.K216K|MYBPC1_ENST00000545503.2_Silent_p.K242K|MYBPC1_ENST00000541119.1_Silent_p.K230K|MYBPC1_ENST00000536007.1_Silent_p.K223K|MYBPC1_ENST00000452455.2_Silent_p.K242K|MYBPC1_ENST00000392934.3_Silent_p.K229K|MYBPC1_ENST00000361685.2_Silent_p.K267K|MYBPC1_ENST00000441232.1_Silent_p.K242K|MYBPC1_ENST00000551300.1_Silent_p.K143K|MYBPC1_ENST00000553190.1_Silent_p.K242K			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	242	Ig-like C2-type 2.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						AGCGACTCAAGCGCATGCGCA	0.617000													7	16					0	0	1	0	0
PDK4	5166	broad.mit.edu	37	7	95221348	95221348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:95221348C>T	ENST00000005178.5	-	6	843	c.646G>A	c.(646-648)Gat>Aat	p.D216N		NM_002612.3	NP_002603.1	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase, isozyme 4	216	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			TAATACTGATCACAGAGCATC	0.313000													59	134					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114154743	114154743	+	Silent	SNP	G	G	A	rs138653304	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:114154743G>A	ENST00000393081.1	+	2	346	c.39G>A	c.(37-39)ccG>ccA	p.P13P	ACSL5_ENST00000354273.4_Silent_p.P13P|ACSL5_ENST00000433418.1_Silent_p.P13P|ACSL5_ENST00000356116.1_Silent_p.P69P|ACSL5_ENST00000354655.4_Silent_p.P13P|ACSL5_ENST00000479936.1_3'UTR	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	13					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		CCCCACTTCCGACCCCGGCGT	0.428000													64	143					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34014926	34014926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34014926G>A	ENST00000389232.4	+	44	6700	c.6630G>A	c.(6628-6630)gtG>gtA	p.V2210V	RYR3_ENST00000415757.3_Silent_p.V2210V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2210	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTGAGAGTGTGGAAGAAAACG	0.542000													40	104					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43039885	43039885	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43039885C>T	ENST00000394056.2	+	13	1875	c.1379_splice	c.e13-1	p.S460_splice	KLC4_ENST00000453940.2_Splice_Site_p.S383_splice|KLC4_ENST00000394058.1_Splice_Site_p.S460_splice|KLC4_ENST00000347162.5_Splice_Site_p.S460_splice|KLC4_ENST00000259708.3_Splice_Site_p.S478_splice|KLC4_ENST00000479388.1_Splice_Site_p.S460_splice			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	460						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			CTCACCACAGCCCCACAGTGA	0.483000													9	124					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41798316	41798316	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41798316C>A	ENST00000392006.3	+	8	1339	c.1166C>A	c.(1165-1167)cCc>cAc	p.P389H	HNRNPUL1_ENST00000352456.3_Missense_Mutation_p.P289H|HNRNPUL1_ENST00000263367.3_Missense_Mutation_p.P300H|HNRNPUL1_ENST00000593587.1_Missense_Mutation_p.P289H|HNRNPUL1_ENST00000378215.4_Missense_Mutation_p.P275H|HNRNPUL1_ENST00000595018.1_Missense_Mutation_p.P289H|HNRNPUL1_ENST00000602130.1_Missense_Mutation_p.P389H	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	389	Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						AGAGCAGAGCCCTACTGTTCT	0.557000													34	84					6.50621e-10	6.5322e-10	1	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140773318	140773318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140773318C>T	ENST00000398604.2	+	1	938	c.938C>T	c.(937-939)tCa>tTa	p.S313L	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGAATGTTCATTTTATGAA	0.358000													38	153					0	0	1	0	0
APBB1	322	broad.mit.edu	37	11	6432347	6432347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6432347G>A	ENST00000389906.2	-	2	330	c.231C>T	c.(229-231)ctC>ctT	p.L77L	APBB1_ENST00000299402.6_Silent_p.L77L|APBB1_ENST00000311051.3_Silent_p.L77L|APBB1_ENST00000533407.1_Intron	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	77					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CGGCCCGCCGGAGCTGGTTCT	0.677000													36	131					0	0	1	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32503507	32503507	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32503507G>T	ENST00000327300.7	+	6	1144	c.977G>T	c.(976-978)gGt>gTt	p.G326V	KHDRBS1_ENST00000307714.8_3'UTR|KHDRBS1_ENST00000492989.1_Missense_Mutation_p.G287V	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	326	Arg/Gly-rich.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ATCACCAGAGGTGCCACTGTG	0.577000													66	143					7.59065e-32	7.64361e-32	1	1	0
PCNXL4	64430	broad.mit.edu	37	14	60592362	60592362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:60592362C>T	ENST00000406854.1	+	10	3642	c.3088C>T	c.(3088-3090)Ctg>Ttg	p.L1030L	PCNXL4_ENST00000535349.1_Silent_p.L237L|PCNXL4_ENST00000406949.1_Silent_p.L796L|PCNXL4_ENST00000404681.2_Silent_p.L1030L|PCNXL4_ENST00000317623.4_Silent_p.L796L					pecanex-like 4 (Drosophila)																		TAGGTATACTCTGAAACTAAT	0.294000													5	4					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54573724	54573724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:54573724G>A	ENST00000064571.2	-	3	1795	c.495C>T	c.(493-495)gtC>gtT	p.V165V		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	165	C1q.					cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			GGTAGAGCAGGACACCATTCG	0.423000													44	78					0	0	1	0	0
OR2K2	26248	broad.mit.edu	37	9	114090533	114090533	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114090533A>G	ENST00000374428.1	-	1	267	c.268T>C	c.(268-270)Tta>Cta	p.L90L	OR2K2_ENST00000302681.1_Silent_p.L61L			Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K, member 2	90					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)	20						CCAAGGAATAAGTACATGGGG	0.413000													21	86					0	0	1	0	0
ZNF480	147657	broad.mit.edu	37	19	52825556	52825556	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52825556C>T	ENST00000595962.1	+	5	1119	c.1053C>T	c.(1051-1053)gcC>gcT	p.A351A	ZNF480_ENST00000490272.1_3'UTR|ZNF480_ENST00000335090.6_Silent_p.A274A|CTD-2525I3.6_ENST00000594379.1_RNA|ZNF480_ENST00000334564.7_Silent_p.A308A	NM_144684.2	NP_653285.2	Q8WV37	ZN480_HUMAN	zinc finger protein 480	351					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		GTGGCAAGGCCTTCTATAGGA	0.378000													29	68					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052332	44052332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:44052332C>T	ENST00000306006.6	-	2	1848	c.1196G>A	c.(1195-1197)gGa>gAa	p.G399E	ZNF239_ENST00000535642.1_Missense_Mutation_p.G399E|ZNF239_ENST00000374446.2_Missense_Mutation_p.G399E|ZNF239_ENST00000426961.1_Missense_Mutation_p.G399E	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						GGGCTTCTCTCCAGTGTGGAC	0.522000													25	51					0	0	1	0	0
GATM	2628	broad.mit.edu	37	15	45656180	45656180	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45656180G>A	ENST00000396659.3	-	8	1416	c.1077C>T	c.(1075-1077)tcC>tcT	p.S359S	GATM_ENST00000558336.1_Silent_p.S359S	NM_001482.2	NP_001473.1	P50440	GATM_HUMAN	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	359					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	15		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	AGACATTCATGGAAAGCCATT	0.358000													33	68					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65145865	65145865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:65145865C>T	ENST00000381210.3	-	12	1127	c.1017G>A	c.(1015-1017)aaG>aaA	p.K339K	TECRL_ENST00000507440.1_Intron	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	339					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						TCTTATGTTTCTTTTGTGCCC	0.254000													13	37					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178942511	178942511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:178942511C>T	ENST00000263967.3	+	16	2475	c.2318C>T	c.(2317-2319)tCc>tTc	p.S773F		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	773					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CGAATTATGTCCTCTGCAAAA	0.328000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			31	95					0	0	1	0	0
SLA	6503	broad.mit.edu	37	8	134057256	134057256	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134057256G>A	ENST00000338087.5	-	7	1276	c.457C>T	c.(457-459)Ctg>Ttg	p.L153L	TG_ENST00000377869.1_Intron|TG_ENST00000519543.1_Intron|TG_ENST00000542445.1_Intron|TG_ENST00000220616.4_Intron|SLA_ENST00000517648.1_Intron|SLA_ENST00000524345.1_Silent_p.L45L|SLA_ENST00000427060.2_Silent_p.L193L|SLA_ENST00000395352.3_Silent_p.L170L	NM_001045556.2	NP_001039021.1	Q13239	SLAP1_HUMAN	Src-like-adaptor	153	SH2.					endosome	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(6)|prostate(1)|skin(1)	17	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			AGGTCCTCCAGGCACTGGAAG	0.512000													18	50					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72539488	72539488	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72539488C>T	ENST00000299290.1	-	5	677	c.288G>A	c.(286-288)ggG>ggA	p.G96G	TBATA_ENST00000545575.1_Silent_p.G86G|TBATA_ENST00000456372.2_Silent_p.G96G	NM_152710.2	NP_689923.2			thymus, brain and testes associated																		AGACAGGCTTCCCGGTGAGAT	0.562000													16	42					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134188628	134188628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:134188628C>T	ENST00000431683.2	+	19	1883	c.1883C>T	c.(1882-1884)cCa>cTa	p.P628L		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	628					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TGGCTTCATCCAGAAGACAAT	0.408000													4	16					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42853768	42853768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42853768C>T	ENST00000334370.4	+	13	2850	c.2215C>T	c.(2215-2217)Cag>Tag	p.Q739*	MEGF8_ENST00000251268.6_Nonsense_Mutation_p.Q806*	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	806						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				AGTAGAGATCCAGGGCCAGCT	0.652000													5	52					0	0	1	0	0
MIR492	574449	broad.mit.edu	37	12	95228202	95228202	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95228202G>A	ENST00000385303.1	+	0	29					NR_030171.1																						CAGGACCATCGAGGACCTGCG	0.552000													12	41					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2740325	2740325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2740325C>T	ENST00000312371.4	+	2	608	c.240C>T	c.(238-240)ttC>ttT	p.F80F	AMZ1_ENST00000407112.1_Silent_p.F80F	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	80							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		TCCAGACCTTCCACGCCTCCC	0.667000													35	90					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64630177	64630177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:64630177C>T	ENST00000357395.3	+	90	16656	c.5512C>T	c.(5512-5514)Ctg>Ttg	p.L1838L	SYNE2_ENST00000358025.3_Silent_p.L5453L|SYNE2_ENST00000394768.2_Silent_p.L1838L|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000554584.1_Silent_p.L5370L|SYNE2_ENST00000344113.4_Silent_p.L5453L|SYNE2_ENST00000555002.1_Silent_p.L2087L			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5453					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTCCAGTGTCCTGGATCGACT	0.527000													19	80					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41900269	41900269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41900269G>A	ENST00000298919.7	+	4	463	c.75G>A	c.(73-75)aaG>aaA	p.K25K	PDZRN4_ENST00000402685.2_Silent_p.K285K|PDZRN4_ENST00000539469.2_Silent_p.K27K			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	285							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCAATGGGAAGGATCTTTCAA	0.438000													11	59					0	0	1	0	0
EID2B	126272	broad.mit.edu	37	19	40023290	40023290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40023290G>A	ENST00000326282.4	-	1	204	c.153C>T	c.(151-153)gcC>gcT	p.A51A	CTB-60E11.9_ENST00000594676.1_RNA|EID2B_ENST00000601837.1_Intron	NM_152361.1	NP_689574.1	Q96D98	EID2B_HUMAN	EP300 interacting inhibitor of differentiation 2B	51					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				endometrium(1)|lung(1)|urinary_tract(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCGCAGCTTCGGCCACTGGGC	0.756000													6	13					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57107002	57107002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:57107002G>A	ENST00000439986.4	-	8	859	c.822C>T	c.(820-822)ggC>ggT	p.G274G	CCBE1_ENST00000398179.2_Intron	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	274	Collagen-like 1.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				GCCCAGGAGGGCCTGGCATAC	0.602000													16	54					0	0	1	0	0
KRT85	3891	broad.mit.edu	37	12	52756698	52756698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52756698G>A	ENST00000257901.3	-	6	1092	c.1017C>T	c.(1015-1017)atC>atT	p.I339I	KRT85_ENST00000544265.1_Silent_p.I127I	NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	339	Coil 2.|Rod.				epidermis development	keratin filament	protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCAGCTCGTTGATCTCCTCCT	0.582000													27	61					0	0	1	0	0
LMO2	4005	broad.mit.edu	37	11	33880946	33880946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:33880946C>T	ENST00000257818.2	-	6	1469	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K	LMO2_ENST00000395833.3_Missense_Mutation_p.E145K	NM_005574.3	NP_005565.2	P25791	RBTN2_HUMAN	LIM domain only 2 (rhombotin-like 1)	145					multicellular organismal development	nucleus	protein binding|zinc ion binding	p.E145K(1)		NS(1)|endometrium(2)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)|urinary_tract(1)	14						ATGTCCTGTTCGCACACTATG	0.502000			T	TRD@	T-ALL								12	37					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45555787	45555787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:45555787C>T	ENST00000588982.1	-	4	2205	c.1704G>A	c.(1702-1704)agG>agA	p.R568R	ZBTB7C_ENST00000586438.1_Silent_p.R568R|ZBTB7C_ENST00000535628.2_Silent_p.R568R|ZBTB7C_ENST00000590800.1_Silent_p.R568R|ZBTB7C_ENST00000332053.2_Silent_p.R568R			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	568						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CCCCCGCGTTCCTCTCAGCCT	0.736000													5	10					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71319397	71319397	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71319397G>T	ENST00000338099.5	-	3	763	c.427C>A	c.(427-429)Ctt>Att	p.L143I	FTSJD1_ENST00000434935.2_Missense_Mutation_p.L143I			Q8IYT2	FTSJ1_HUMAN		143						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GCTTCACAAAGGTGTAGAGAA	0.413000													21	113					7.41877e-09	7.44533e-09	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79328522	79328522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79328522C>T	ENST00000376718.3	-	7	995	c.872G>A	c.(871-873)cGa>cAa	p.R291Q	PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	291					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AGCAATCTGTCGTCTCGGCTG	0.502000													3	9					0	0	1	0	0
HOXB2	3212	broad.mit.edu	37	17	46620486	46620486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46620486C>T	ENST00000330070.4	-	2	2182	c.1015G>A	c.(1015-1017)Gaa>Aaa	p.E339K	HOXB2_ENST00000504772.3_5'UTR	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	339					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						TCCAGCTCTTCCTCGGAAAAA	0.597000													39	76					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735154	55735154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55735154C>T	ENST00000312345.2	-	1	836	c.786G>A	c.(784-786)ggG>ggA	p.G262G		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AAATCAGTTTCCCCATCCTTT	0.373000													15	44					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28598107	28598107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28598107C>T	ENST00000434452.1	-	9	1347	c.1193G>A	c.(1192-1194)gGa>gAa	p.G398E	DSC3_ENST00000360428.4_Missense_Mutation_p.G398E	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	398	Cadherin 3.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ATTTTCATTTCCCTTTAAAAT	0.318000													29	96					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61570356	61570356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61570356C>T	ENST00000457692.1	+	9	1398	c.1065C>T	c.(1063-1065)ttC>ttT	p.F355F	SERPINB2_ENST00000299502.4_Silent_p.F355F	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	355					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CTGAAGTGTTCCACCAAGCCA	0.542000													27	83					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11630225	11630225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:11630225G>A	ENST00000423059.3	-	4	1566	c.1315C>T	c.(1315-1317)Cct>Tct	p.P439S		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	439	TSP type-1 4.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTGAGCAAAGGGTCCACACGG	0.537000										HNSCC(18;0.044)			5	26					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98916675	98916675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98916675G>A	ENST00000477737.1	+	25	3620	c.3416G>A	c.(3415-3417)cGg>cAg	p.R1139Q	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1139										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TGTAACAACCGGAGAGTAAGT	0.448000													44	105					0	0	1	0	0
PRB3	5544	broad.mit.edu	37	12	11420578	11420578	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11420578C>T	ENST00000381842.3	-	0	642				PRB3_ENST00000279573.6_RNA|PRB3_ENST00000538488.1_RNA|PRB3_ENST00000440870.3_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TTCTGGCTTTCCCGGACGAGG	0.627000													58	363					0	0	1	0	0
CDK8	1024	broad.mit.edu	37	13	26974631	26974631	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:26974631C>T	ENST00000381527.3	+	10	1478	c.975C>T	c.(973-975)acC>acT	p.T325T	CDK8_ENST00000536792.1_3'UTR|CDK8_ENST00000480323.1_3'UTR	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	325	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGCGAATTACCTCAGAACAGG	0.423000													17	204					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584536	7584536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7584536C>T	ENST00000379802.3	+	24	7382	c.7041C>T	c.(7039-7041)atC>atT	p.I2347I	DSP_ENST00000418664.2_Silent_p.I1748I	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2347	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CAGGAAACATCATCTCTTTGT	0.473000													15	68					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19337321	19337321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19337321G>A	ENST00000252575.5	+	7	1142	c.1099G>A	c.(1099-1101)Gac>Aac	p.D367N		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	367					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			ACAACATGGAGACCTAGAGAC	0.577000													13	91					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31645925	31645925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:31645925G>A	ENST00000357033.4	-	55	8288	c.8082C>T	c.(8080-8082)ttC>ttT	p.F2694F	DMD_ENST00000474231.1_Silent_p.F234F|DMD_ENST00000359836.1_Silent_p.F234F|DMD_ENST00000378677.2_Silent_p.F2690F|DMD_ENST00000378707.3_Silent_p.F234F|DMD_ENST00000343523.2_Silent_p.F234F|DMD_ENST00000541735.1_Silent_p.F234F	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2694					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGTCCAGGGGGAACTGTTGCA	0.453000													10	11					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169939973	169939973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169939973C>T	ENST00000327239.4	+	6	1952	c.448C>T	c.(448-450)Cct>Tct	p.P150S	DHRS9_ENST00000428522.1_Missense_Mutation_p.P150S|DHRS9_ENST00000412271.1_Missense_Mutation_p.P150S|DHRS9_ENST00000357546.2_Missense_Mutation_p.P150S|DHRS9_ENST00000421653.1_Missense_Mutation_p.P3S|DHRS9_ENST00000602501.1_Missense_Mutation_p.P150S|DHRS9_ENST00000436483.2_Missense_Mutation_p.P150S|DHRS9_ENST00000432060.2_Missense_Mutation_p.P210S	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	150					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						AAATATGCTTCCTTTGGTCAA	0.483000													39	115					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76757136	76757136	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76757136C>T	ENST00000536229.3	+	3	3811	c.3102C>T	c.(3100-3102)ccC>ccT	p.P1034P	SALL3_ENST00000537592.2_Silent_p.P1239P|SALL3_ENST00000575389.2_Silent_p.P1167P			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCGGCATCCCCCAGCTCCCCG	0.617000													35	161					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10934538	10934538	+	Missense_Mutation	SNP	C	C	T	rs121909095		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10934538C>T	ENST00000314646.5	+	17	2020	c.1856C>T	c.(1855-1857)tCg>tTg	p.S619L	DNM2_ENST00000389253.4_Missense_Mutation_p.S619L|DNM2_ENST00000585892.1_Missense_Mutation_p.S619L|DNM2_ENST00000408974.4_Missense_Mutation_p.S615L|DNM2_ENST00000359692.6_Missense_Mutation_p.S615L|DNM2_ENST00000355667.6_Missense_Mutation_p.S619L			P50570	DYN2_HUMAN	dynamin 2	619	PH.		S -> L (in ADCNM; severe).|S -> W (in ADCNM; severe).		G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TGGAAGGCCTCGTTCCTCCGA	0.677000			"""F, N, Splice, Mis, O"""		ETP ALL								23	60					0	0	1	0	0
LCE1E	353135	broad.mit.edu	37	1	152760099	152760099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152760099G>A	ENST00000368770.3	+	2	377	c.324G>A	c.(322-324)ggG>ggA	p.G108G	LCE1E_ENST00000368771.1_Silent_p.G108G	NM_178353.1	NP_848130.1	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	108	Cys-rich.				keratinization					lung(5)|stomach(1)	6	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGTGGAGGGGGCAGCGGCC	0.617000													43	130					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189868721	189868721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189868721C>T	ENST00000304636.3	+	39	2845	c.2675C>T	c.(2674-2676)cCc>cTc	p.P892L	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	892	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AACCCAGGACCCCCAGGTCCC	0.428000													4	25					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2800046	2800046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2800046G>A	ENST00000520002.1	-	70	11041	c.10486C>T	c.(10486-10488)Cct>Tct	p.P3496S	CSMD1_ENST00000542608.1_Missense_Mutation_p.P3318S|CSMD1_ENST00000537824.1_Missense_Mutation_p.P3495S|CSMD1_ENST00000602723.1_Missense_Mutation_p.P3319S|CSMD1_ENST00000400186.3_Missense_Mutation_p.P3319S|CSMD1_ENST00000602557.1_Missense_Mutation_p.P3496S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3496						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCAAAGAAAGGAACCAGAATG	0.418000													5	14					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502575	90502575	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90502575G>A	ENST00000325643.5	+	4	3239	c.3173G>A	c.(3172-3174)gGa>gAa	p.G1058E		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCAAGTTCGGGAAGTGTTCAG	0.597000													16	88					0	0	1	0	0
PRKCSH	5589	broad.mit.edu	37	19	11558330	11558330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11558330C>T	ENST00000252455.2	+	11	1262	c.926C>T	c.(925-927)tCg>tTg	p.S309L	PRKCSH_ENST00000412601.1_Missense_Mutation_p.S309L|PRKCSH_ENST00000592741.1_Missense_Mutation_p.S309L|PRKCSH_ENST00000591462.1_Missense_Mutation_p.S309L|PRKCSH_ENST00000587327.1_Missense_Mutation_p.S309L|PRKCSH_ENST00000589838.1_Missense_Mutation_p.S309L	NM_002743.2	NP_002734.2	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H	309					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(3)	19						CCAGTGCCCTCGTCGCCCACA	0.667000													12	28					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32813968	32813968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32813968C>T	ENST00000380250.3	+	46	7133	c.6637C>T	c.(6637-6639)Cat>Tat	p.H2213Y		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TCGATACCTTCATGAAGCATA	0.428000													15	68					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176915162	176915162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176915162C>T	ENST00000367654.2	-	13	2186	c.2173G>A	c.(2173-2175)Gag>Aag	p.E725K	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.E717K|ASTN1_ENST00000367657.3_Missense_Mutation_p.E717K|ASTN1_ENST00000361833.2_Missense_Mutation_p.E717K			O14525	ASTN1_HUMAN	astrotactin 1	725					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						ATGGGAAGCTCCCTGCTTTCC	0.532000													31	90					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47767944	47767944	+	Missense_Mutation	SNP	G	G	A	rs147160336	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47767944G>A	ENST00000360380.3	-	5	590	c.227C>T	c.(226-228)tCg>tTg	p.S76L	STIL_ENST00000396221.2_Missense_Mutation_p.S76L|STIL_ENST00000337817.5_Missense_Mutation_p.S76L|STIL_ENST00000371877.3_Missense_Mutation_p.S76L|STIL_ENST00000243182.6_Missense_Mutation_p.S76L			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	76					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				AAAGCATGACGAATTTTTTTT	0.413000													21	66					0	0	1	0	0
FCER2	2208	broad.mit.edu	37	19	7754151	7754151	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7754151C>T	ENST00000346664.5	-	11	1106	c.894G>A	c.(892-894)gaG>gaA	p.E298E	FCER2_ENST00000360067.4_Silent_p.E297E|FCER2_ENST00000597921.1_Silent_p.E298E	NM_001220500.1|NM_002002.4	NP_001207429.1|NP_001993.2	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor for (CD23)	298					positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10						GTCCCATGGACTCCGCGGAAC	0.672000													8	20					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14107221	14107221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:14107221C>T	ENST00000235372.7	+	8	3787	c.2931C>T	c.(2929-2931)ccC>ccT	p.P977P	PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000311066.5_Silent_p.P977P|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000413440.1_Silent_p.P776P|PRDM2_ENST00000343137.4_Silent_p.P776P	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	977	Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CACCCTGTCCCCCGGTATTAA	0.607000													18	179					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33875446	33875446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33875446G>A	ENST00000374408.3	-	4	1232	c.1136C>T	c.(1135-1137)tCg>tTg	p.S379L		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	379										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			ACCCAGGGACGAGGACACCAC	0.632000													11	25					0	0	1	0	0
PUS7L	83448	broad.mit.edu	37	12	44148716	44148716	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:44148716G>A	ENST00000416848.2	-	2	821	c.333C>T	c.(331-333)atC>atT	p.I111I	PUS7L_ENST00000431332.3_Intron|PUS7L_ENST00000551923.1_Silent_p.I111I|PUS7L_ENST00000553166.1_Silent_p.I111I|PUS7L_ENST00000344862.5_Silent_p.I111I	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	111					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TTCCATCAACGATAGTATCTT	0.348000													26	63					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63883878	63883878	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63883878G>A	ENST00000246841.3	+	2	1182	c.139G>A	c.(139-141)Gag>Aag	p.E47K	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	19	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CTTCCTGACGGAGGTCATCGA	0.637000													13	35					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98351872	98351872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98351872G>A	ENST00000264972.5	+	10	1457	c.1242G>A	c.(1240-1242)atG>atA	p.M414I	ZAP70_ENST00000442208.1_Missense_Mutation_p.M288I|ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000451498.2_Missense_Mutation_p.M107I	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	414	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						TGCTGGTCATGGAGATGGCTG	0.677000													25	152					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116858451	116858451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116858451G>A	ENST00000374118.3	-	6	598	c.361C>T	c.(361-363)Cct>Tct	p.P121S	KIF12_ENST00000473174.1_Intron	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	254	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						CCACCAACAGGGGGCTCCCCA	0.597000													7	55					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42221651	42221651	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42221651C>T	ENST00000221992.6	+	5	1350	c.1237_splice	c.e5+1	p.L412_splice	CEACAM5_ENST00000398599.4_Splice_Site_p.L411_splice|CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000405816.1_Splice_Site_p.L412_splice	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	412	Ig-like 4.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TGAATGTCCTCTGTGAGTATC	0.512000													66	154					0	0	1	0	0
RPS5	6193	broad.mit.edu	37	19	58906062	58906062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58906062C>T	ENST00000596046.1	+	5	1409	c.560C>T	c.(559-561)tCc>tTc	p.S187F	RPS5_ENST00000196551.3_Missense_Mutation_p.S187F|RPS5_ENST00000598495.1_Missense_Mutation_p.S208F|RPS5_ENST00000598098.1_Missense_Mutation_p.S117F|RPS5_ENST00000601521.1_Missense_Mutation_p.S187F			P46782	RS5_HUMAN	ribosomal protein S5	187					endocrine pancreas development|regulation of translational fidelity|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|structural constituent of ribosome			cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4		all_cancers(17;1.71e-22)|all_epithelial(17;1.69e-16)|Lung NSC(17;2.25e-06)|all_lung(17;9.97e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Breast(46;0.0194)|Ovarian(87;0.0443)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.171)|GBM - Glioblastoma multiforme(193;0.0323)|Lung(386;0.0543)|LUSC - Lung squamous cell carcinoma(496;0.176)		TCCTCGAACTCCTATGCCATT	0.567000													46	124					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112998264	112998264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112998264C>T	ENST00000495514.1	+	12	2686	c.1982C>T	c.(1981-1983)cCa>cTa	p.P661L	BOC_ENST00000355385.3_Missense_Mutation_p.P661L|BOC_ENST00000273395.4_Missense_Mutation_p.P662L			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	661	Fibronectin type-III 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			GCCATCCCCCCATCGCGGCTG	0.627000													12	55					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118520021	118520021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:118520021G>A	ENST00000359236.5	-	3	851	c.575C>T	c.(574-576)tCg>tTg	p.S192L		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	192	Ig-like C2-type 2.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						GAGGTTTGGCGATATCAGTAA	0.517000													20	76					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111861848	111861848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111861848G>A	ENST00000369740.1	+	10	1125	c.1022G>A	c.(1021-1023)aGc>aAc	p.S341N	RP5-1125M8.2_ENST00000426321.1_RNA|CHIA_ENST00000353665.6_Missense_Mutation_p.S180N|CHIA_ENST00000343320.6_Missense_Mutation_p.S341N|CHIA_ENST00000483391.1_Missense_Mutation_p.S180N|CHIA_ENST00000451398.2_Missense_Mutation_p.S180N|CHIA_ENST00000430615.1_Missense_Mutation_p.S233N	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	341					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		AACATCAAGAGCTTCGATATT	0.478000													27	71					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45412651	45412651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45412651C>T	ENST00000331493.2	+	5	531	c.120C>T	c.(118-120)atC>atT	p.I40I	ITGB3_ENST00000435993.2_3'UTR|EFCAB13_ENST00000520802.1_Intron|EFCAB13_ENST00000517484.1_Silent_p.I40I|ITGB3_ENST00000560629.1_3'UTR	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		AGAAATACATCAAGTTTTCTA	0.318000													45	67					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39793585	39793585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39793585C>T	ENST00000373272.2	+	13	1635	c.1230C>T	c.(1228-1230)atC>atT	p.I410I	PLCG1_ENST00000244007.3_Silent_p.I410I|PLCG1_ENST00000373271.1_Silent_p.I410I	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	410	PI-PLC X-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				ACCCAGTCATCCTGTCCATTG	0.547000													27	48					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38858758	38858758	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38858758C>T	ENST00000409235.3	+	26	3116	c.3001C>T	c.(3001-3003)Cac>Tac	p.H1001Y	CATSPERG_ENST00000410018.1_Missense_Mutation_p.H961Y|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	1001					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						CATCATGTCCCACGAGAGCCC	0.602000													40	85					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83456109	83456109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83456109C>T	ENST00000334574.8	-	2	215	c.34G>A	c.(34-36)Gac>Aac	p.D12N	FSD2_ENST00000541889.1_Missense_Mutation_p.D12N			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	12										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						GTAGACCTGTCCAGCCCCAGT	0.468000													64	63					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15113846	15113846	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15113846G>A	ENST00000378217.3	+	8	971	c.784G>A	c.(784-786)Gga>Aga	p.G262R	OLAH_ENST00000485251.1_Intron|OLAH_ENST00000378228.3_Missense_Mutation_p.G209R	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	209					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						ATGTTTTGTTGGATCTGAAGA	0.323000													42	98					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87678484	87678484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:87678484G>A	ENST00000284262.2	+	2	1245	c.1003G>A	c.(1003-1005)Gag>Aag	p.E335K		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	335					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CACCAAGGAGGAGGGCAAGTA	0.662000													15	52					0	0	1	0	0
LBP	3929	broad.mit.edu	37	20	36979297	36979297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36979297C>T	ENST00000217407.2	+	3	484	c.323C>T	c.(322-324)tCc>tTc	p.S108F		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	108					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				ATCTCCGACTCCTCCATCCGG	0.612000													29	69					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65124444	65124444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:65124444G>A	ENST00000371073.2	+	13	1839	c.1839G>A	c.(1837-1839)gtG>gtA	p.V613V	CACHD1_ENST00000290039.5_Silent_p.V562V|CACHD1_ENST00000495994.1_3'UTR			Q5VU97	CAHD1_HUMAN	cache domain containing 1	613					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						AAATACCTGTGAAACAACTGA	0.448000													8	11					0	0	1	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77515942	77515942	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:77515942G>A	ENST00000477717.1	+	4	906		c.e4-1			NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5						protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						GTTCCTTCCAGGAAGATATCC	0.423000													11	175					0	0	1	0	0
CNN3	1266	broad.mit.edu	37	1	95368697	95368697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:95368697G>A	ENST00000370206.4	-	3	610	c.227C>T	c.(226-228)tCc>tTc	p.S76F	CNN3_ENST00000538964.1_Missense_Mutation_p.S76F|CNN3_ENST00000394202.4_Missense_Mutation_p.S76F|CNN3_ENST00000545882.1_Missense_Mutation_p.S35F|CNN3_ENST00000487539.1_5'UTR	NM_001839.3	NP_001830.1	Q15417	CNN3_HUMAN	calponin 3, acidic	76	CH.				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|stomach(1)|urinary_tract(2)	18		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		GTTCAGTGAGGACTCGTTGAC	0.403000													25	47					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113418951	113418951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113418951G>A	ENST00000297405.5	-	35	5855	c.5611C>T	c.(5611-5613)Cct>Tct	p.P1871S	CSMD3_ENST00000352409.3_Missense_Mutation_p.P1801S|CSMD3_ENST00000343508.3_Missense_Mutation_p.P1831S|CSMD3_ENST00000455883.2_Missense_Mutation_p.P1767S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1871						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTTGTTCTAGGAACAGCTGTG	0.318000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			41	56					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25834646	25834646	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25834646G>A	ENST00000399878.3	-	5	1191	c.1069C>T	c.(1069-1071)Cga>Tga	p.R357*	SEL1L3_ENST00000264868.5_Nonsense_Mutation_p.R322*|SEL1L3_ENST00000502949.1_Nonsense_Mutation_p.R204*	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	357						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						ATATCCAGTCGAAACCACTCC	0.393000													29	71					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328875	88328875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:88328875C>T	ENST00000325089.6	+	2	1451	c.1232C>T	c.(1231-1233)cCc>cTc	p.P411L	SLITRK5_ENST00000400028.3_Missense_Mutation_p.P170L	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	411						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCCTACAATCCCAAGAAAATG	0.557000													10	25					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075173	9075173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9075173C>T	ENST00000397910.4	-	3	12476	c.12273G>A	c.(12271-12273)atG>atA	p.M4091I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4093	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.M4091I(4)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGCAAGGATCATTCCTCCAG	0.527000													27	61					0	0	1	0	0
GALNT5	11227	broad.mit.edu	37	2	158142628	158142628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158142628G>A	ENST00000259056.4	+	3	2208	c.1723G>A	c.(1723-1725)Gga>Aga	p.G575R		NM_014568.1	NP_055383.1	Q7Z7M9	GALT5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	575	Catalytic subdomain A.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(4)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	56						CAGGCTGGCAGGAGCACAGAA	0.343000													20	66					0	0	1	0	0
OPHN1	4983	broad.mit.edu	37	X	67293003	67293003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:67293003C>T	ENST00000355520.5	-	20	2466	c.1825G>A	c.(1825-1827)Gaa>Aaa	p.E609K	OPHN1_ENST00000540071.1_Missense_Mutation_p.E609K|OPHN1_ENST00000484842.1_5'UTR	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	609					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						CCTTCGCTTTCATCCAGGGAA	0.483000													9	2					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058091	79058091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79058091C>T	ENST00000388820.4	-	19	4372	c.4162G>A	c.(4162-4164)Gtc>Atc	p.V1388I		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1388					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GTCTCAGGGACTCTGTGGCTG	0.682000													7	75					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110468503	110468503	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110468503C>T	ENST00000378402.5	+	46	6991	c.6887C>T	c.(6886-6888)cCt>cTt	p.P2296L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2296	G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTGCCTGTTCCTGTGACCTGG	0.363000										HNSCC(38;0.096)			3	28					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84592779	84592779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84592779C>T	ENST00000286744.5	+	17	2335	c.2111C>T	c.(2110-2112)cCc>cTc	p.P704L	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.P704L	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	704	TSP type-1 5.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GAGCCCTGTCCCCCCAGGTAT	0.542000													9	43					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16877459	16877459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:16877459G>A	ENST00000355661.3	-	5	318	c.308C>T	c.(307-309)cCg>cTg	p.P103L	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.P103L|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.P103L			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	103					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						ATGTGGATTCGGCCTGTGAGG	0.532000													55	160					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30732918	30732918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30732918C>T	ENST00000217315.5	+	7	966	c.626C>T	c.(625-627)tCg>tTg	p.S209L	TM9SF4_ENST00000398022.2_Missense_Mutation_p.S226L			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	226						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GAGAAGAGTTCGTGCACTCTG	0.562000													23	52					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48428946	48428946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48428946G>A	ENST00000224605.2	-	2	1205	c.940C>T	c.(940-942)Cac>Tac	p.H314Y		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	314					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						TGCTGTGCGTGGGCGCGCGGC	0.716000													9	14					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23826227	23826227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23826227C>T	ENST00000354639.3	+	19	2770	c.2306C>T	c.(2305-2307)cCa>cTa	p.P769L	STK31_ENST00000433467.2_Missense_Mutation_p.P792L|STK31_ENST00000355870.3_Missense_Mutation_p.P792L|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Missense_Mutation_p.P769L	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	792	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GGGTTACTGCCATTGATATTC	0.378000													25	81					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87966146	87966146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87966146G>A	ENST00000327946.7	-	3	580	c.495C>T	c.(493-495)ttC>ttT	p.F165F		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	165						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AGAACATGACGAACTTCTGCC	0.617000										Multiple Myeloma(13;0.14)			6	58					0	0	1	0	0
CD38	952	broad.mit.edu	37	4	15826515	15826515	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:15826515G>A	ENST00000226279.2	+	3	512	c.375G>A	c.(373-375)tgG>tgA	p.W125*		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	125					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						TTCTTCTTTGGAGCAGAATAA	0.388000													19	86					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54798336	54798336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54798336G>A	ENST00000474759.1	+	13	1386	c.1338G>A	c.(1336-1338)caG>caA	p.Q446Q	CACNA2D3_ENST00000415676.2_Silent_p.Q446Q|CACNA2D3_ENST00000288197.5_Silent_p.Q446Q|CACNA2D3_ENST00000490478.1_Silent_p.Q352Q	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	446						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TCATCGACCAGGAGCATGATG	0.512000													39	74					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152521994	152521994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152521994C>T	ENST00000427231.2	-	42	5293	c.5091G>A	c.(5089-5091)gaG>gaA	p.E1697E	NEB_ENST00000409198.1_Silent_p.E1697E|NEB_ENST00000397345.3_Silent_p.E1697E|NEB_ENST00000604864.1_Silent_p.E1697E|NEB_ENST00000172853.10_Silent_p.E1697E|NEB_ENST00000603639.1_Silent_p.E1697E	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1697					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCTCCAGGGACTCTATGGGCA	0.448000													7	14					0	0	1	0	0
OR8D4	338662	broad.mit.edu	37	11	123777308	123777308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123777308C>T	ENST00000321355.2	+	1	200	c.170C>T	c.(169-171)aCc>aTc	p.T57I		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		CAACTTCATACCCCCATGTAC	0.403000													42	147					0	0	1	0	0
GRAP2	9402	broad.mit.edu	37	22	40351840	40351840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40351840G>A	ENST00000344138.4	+	3	359	c.96G>A	c.(94-96)gaG>gaA	p.E32E	GRAP2_ENST00000478445.1_3'UTR|GRAP2_ENST00000543252.1_Silent_p.E32E|GRAP2_ENST00000540310.1_Intron|GRAP2_ENST00000399090.2_Intron|GRAP2_ENST00000544756.1_Intron|GRAP2_ENST00000407075.3_Silent_p.E32E	NM_004810.2	NP_004801.1	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	32	SH3 1.				cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						GTAACCAAGAGGAGTGGTTTA	0.458000													6	60					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48736830	48736830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48736830C>T	ENST00000316623.5	-	49	6400	c.5945G>A	c.(5944-5946)aGa>aAa	p.R1982K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1982	EGF-like 34; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGCACATTTTCTGGGTTCTAG	0.398000													49	106					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52250020	52250020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52250020G>A	ENST00000595042.1	-	3	369	c.228C>T	c.(226-228)tcC>tcT	p.S76S	FPR1_ENST00000304748.4_Silent_p.S76S	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	76					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	ATGGCAAAGTGGAGGTGAAAC	0.522000													34	60					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027077	37027077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37027077C>T	ENST00000358047.3	+	1	646	c.594C>T	c.(592-594)ctC>ctT	p.L198L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	198										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TGTCCTGTCTCCCCCCGGAGC	0.642000													21	15					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47650329	47650329	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47650329C>T	ENST00000398742.2	+	5	1879	c.1830C>T	c.(1828-1830)ttC>ttT	p.F610F	GPR111_ENST00000507065.1_Silent_p.F610F|GPR111_ENST00000296862.1_Silent_p.F678F			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	678					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						CCCTGGCCTTCCACATTATCT	0.478000													20	49					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55912872	55912872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55912872G>A	ENST00000373965.2	-	15	2187	c.1793C>T	c.(1792-1794)cCt>cTt	p.P598L	PCDH15_ENST00000395445.1_Missense_Mutation_p.P598L|PCDH15_ENST00000373957.3_Missense_Mutation_p.P569L|PCDH15_ENST00000395446.1_Missense_Mutation_p.P591L|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.P596L|PCDH15_ENST00000395433.1_Missense_Mutation_p.P569L|PCDH15_ENST00000395430.1_Missense_Mutation_p.P591L|PCDH15_ENST00000373955.1_Missense_Mutation_p.P591L|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.P591L|PCDH15_ENST00000395438.1_Missense_Mutation_p.P591L|PCDH15_ENST00000409834.1_Missense_Mutation_p.P202L|PCDH15_ENST00000437009.1_Missense_Mutation_p.P591L|PCDH15_ENST00000320301.6_Missense_Mutation_p.P591L|PCDH15_ENST00000395432.2_Missense_Mutation_p.P554L	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	591	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCGCTCTGCAGGAGGAGCATT	0.453000										HNSCC(58;0.16)			14	54					0	0	1	0	0
DIO3	1735	broad.mit.edu	37	14	102027848	102027848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102027848C>T	ENST00000510508.4	+	1	161	c.15C>T	c.(13-15)gcC>gcT	p.A5A	DIO3_ENST00000359323.3_5'UTR			P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	0					cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(3)|skin(1)	22		all_neural(303;0.185)				CTCGCCAGGCCACGTCGCGGT	0.667000													9	11					0	0	1	0	0
PGA5	5222	broad.mit.edu	37	11	61015963	61015963	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61015963G>A	ENST00000312403.5	+	6	914	c.729G>A	c.(727-729)tgG>tgA	p.W243*	PGA5_ENST00000451616.2_Nonsense_Mutation_p.W89*|CTD-2331C18.5_ENST00000537594.1_RNA|PGA4_ENST00000422676.2_Nonsense_Mutation_p.W243*	NM_014224.2	NP_055039.1	P00790	PEPA_HUMAN	pepsinogen 5, group I (pepsinogen A)	243					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			large_intestine(1)|skin(1)	2						GTCTGAACTGGGTGCCTGTTA	0.547000													81	206					0	0	1	0	0
MKNK1	8569	broad.mit.edu	37	1	47042299	47042299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47042299G>A	ENST00000371946.4	-	5	425	c.262C>T	c.(262-264)Cgg>Tgg	p.R88W	MKNK1_ENST00000428112.2_Missense_Mutation_p.R88W|MKNK1_ENST00000341183.5_Missense_Mutation_p.R88W|MKNK1_ENST00000371944.4_Silent_p.V17V|MKNK1_ENST00000545730.1_Missense_Mutation_p.R88W|MKNK1_ENST00000371945.4_Missense_Mutation_p.R88W	NM_003684.5	NP_003675.2	Q9BUB5	MKNK1_HUMAN	MAP kinase interacting serine/threonine kinase 1	88	Protein kinase.				intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	13	Acute lymphoblastic leukemia(166;0.155)					ACCCTACTCCGACTGTGCCCT	0.522000													36	103					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10428434	10428434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10428434G>A	ENST00000293677.6	-	12	2137	c.2056C>T	c.(2056-2058)Ccg>Tcg	p.P686S	CTD-2369P2.12_ENST00000586529.1_Missense_Mutation_p.P87S	NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	513						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GACCCCAGCGGGGAAGAGCCG	0.692000													4	14					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848668	73848668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73848668G>A	ENST00000523207.1	+	3	1666	c.1078G>A	c.(1078-1080)Gaa>Aaa	p.E360K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	360					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TGAGAAGGATGAAGATGCTAC	0.438000													40	182					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153431438	153431438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153431438G>A	ENST00000368723.3	-	2	162	c.52C>T	c.(52-54)Cac>Tac	p.H18Y	S100A7_ENST00000368722.1_Missense_Mutation_p.H18Y	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	18	EF-hand 1.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTGTATTTGTGAAACATGTCG	0.438000													54	144					0	0	1	0	0
USP44	84101	broad.mit.edu	37	12	95927254	95927254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95927254G>A	ENST00000258499.3	-	2	1067	c.779C>T	c.(778-780)tCc>tTc	p.S260F	USP44_ENST00000552440.1_Missense_Mutation_p.S260F|USP44_ENST00000537435.2_Missense_Mutation_p.S260F|USP44_ENST00000393091.2_Missense_Mutation_p.S260F	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	260					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						TTTAACTGAGGAGTCACTGAC	0.393000													23	98					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157737078	157737078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157737078C>T	ENST00000361516.3	-	6	1153	c.1105G>A	c.(1105-1107)Gag>Aag	p.E369K	FCRL2_ENST00000368181.4_Intron|FCRL2_ENST00000469986.1_Missense_Mutation_p.E116K|FCRL2_ENST00000392274.3_Missense_Mutation_p.E369K	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	369	Ig-like C2-type 4.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTGTTGGCCTCACAGGAGTAG	0.567000													30	129					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79364219	79364219	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79364219G>A	ENST00000444841.1	-	0	285																											AAGTAGATTGGAAAGTTTTGG	0.483000													3	10					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742556	23742556	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23742556G>A	ENST00000255890.4	-	0	653																											AGGGGCTGCAGGGCCACGTAG	0.642000													7	15					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70375179	70375179	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70375179C>T	ENST00000374051.3	+	4	955	c.633C>T	c.(631-633)atC>atT	p.I211I	NLGN3_ENST00000536169.1_Silent_p.I191I|NLGN3_ENST00000358741.3_Silent_p.I231I|NLGN3_ENST00000476589.1_3'UTR	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	231					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					GCAATGTCATCGTCATCACCC	0.542000													36	30					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76891507	76891507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76891507G>A	ENST00000409709.3	+	22	2946	c.2674G>A	c.(2674-2676)Gag>Aag	p.E892K	MYO7A_ENST00000409619.2_Missense_Mutation_p.E881K|MYO7A_ENST00000458637.2_Missense_Mutation_p.E892K|MYO7A_ENST00000409893.1_Missense_Mutation_p.E892K	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	892					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GGCCAAGGAGGAGGCCGAGCG	0.612000													6	22					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134886335	134886335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134886335C>T	ENST00000607359.1	+	3	369	c.369C>T	c.(367-369)ttC>ttT	p.F123F				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	505						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CCTCAGGGTTCTTGGGACCTG	0.582000													8	18					0	0	1	0	0
RAB37	326624	broad.mit.edu	37	17	72740483	72740483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72740483G>A	ENST00000340415.3	+	6	1391	c.382G>A	c.(382-384)Gac>Aac	p.D128N	RAB37_ENST00000402449.4_Missense_Mutation_p.D128N|RAB37_ENST00000392615.5_Missense_Mutation_p.D103N|RAB37_ENST00000528438.1_Missense_Mutation_p.D108N|RAB37_ENST00000392610.1_Missense_Mutation_p.D135N|RAB37_ENST00000392613.5_Missense_Mutation_p.D135N|RAB37_ENST00000392614.4_Missense_Mutation_p.D140N|RAB37_ENST00000392612.3_Missense_Mutation_p.D98N	NM_175738.4	NP_783865.1	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family	135					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	12						TGCCCAGAGGGACGTGGTGAT	0.612000											OREG0024716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	85					0	0	1	0	0
ABCF2	10061	broad.mit.edu	37	7	150915701	150915701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150915701G>A	ENST00000287844.2	-	10	1282	c.1173C>T	c.(1171-1173)atC>atT	p.I391I	ABCF2_ENST00000222388.2_Silent_p.I391I|ABCF2_ENST00000473874.1_5'UTR	NM_007189.1	NP_009120.1	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 2	391						ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(15)|ovary(1)|skin(2)	24			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGGTGGAGGGATCTTGCCAC	0.478000													10	67					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370509	38370509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38370509G>A	ENST00000322350.5	+	6	1003	c.657G>A	c.(655-657)atG>atA	p.M219I	EGFLAM_ENST00000354891.3_Missense_Mutation_p.M219I	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	219	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TGAGGGCAATGAATTCCCATG	0.562000													8	43					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7675417	7675417	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7675417C>T	ENST00000446248.2	+	8	998	c.897C>T	c.(895-897)ctC>ctT	p.L299L	CAMSAP3_ENST00000160298.4_Silent_p.L272L	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	272	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						ACCTCCAGCTCGTGCAGGATT	0.612000													53	158					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15582830	15582830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15582830C>T	ENST00000292609.4	-	3	1343	c.1214G>A	c.(1213-1215)gGa>gAa	p.G405E	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.G405E			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	405					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GTACAAGAATCCCAGCGGCAG	0.672000													13	38					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15843464	15843464	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:15843464C>T	ENST00000217246.4	+	9	1115	c.720C>T	c.(718-720)ttC>ttT	p.F240F	MACROD2_ENST00000402914.1_Silent_p.F5F|MACROD2_ENST00000310348.4_Silent_p.F240F|MACROD2_ENST00000378058.3_Silent_p.F5F	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	240	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				ATGAGTTTTTCTCCGTAGGTG	0.363000													9	33					0	0	1	0	0
KIF4A	24137	broad.mit.edu	37	X	69622482	69622482	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69622482A>T	ENST00000374403.3	+	23	2638	c.2556A>T	c.(2554-2556)caA>caT	p.Q852H	KIF4A_ENST00000374388.3_Missense_Mutation_p.Q852H	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	852	Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						GACCAAAACAACGCTGGGAGA	0.468000													14	17					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114380964	114380964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114380964G>A	ENST00000359785.5	-	13	1193	c.1058C>T	c.(1057-1059)tCc>tTc	p.S353F	PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000525799.1_Missense_Mutation_p.S226F|PTPN22_ENST00000528414.1_Missense_Mutation_p.S298F|PTPN22_ENST00000538253.1_Missense_Mutation_p.S109F|PTPN22_ENST00000420377.2_Missense_Mutation_p.S353F	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	353					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGTCAAAGGAAGAAGATTC	0.348000													12	28					0	0	1	0	0
C7orf62	219557	broad.mit.edu	37	7	88423588	88423588	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:88423588G>A	ENST00000297203.2	-	2	854	c.669C>T	c.(667-669)ttC>ttT	p.F223F	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	223										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						CCGGGTCCATGAATTCTTCGG	0.438000													33	69					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230669	36230669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36230669G>A	ENST00000303965.4	-	2	929	c.440C>T	c.(439-441)tCt>tTt	p.S147F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	147					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTTAGGAGGAGACAGCTTATC	0.413000													26	62					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94052354	94052354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94052354G>A	ENST00000297268.6	+	40	2960	c.2489G>A	c.(2488-2490)cGa>cAa	p.R830Q		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	830			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCAGTTGGCCGAACTGGAGAA	0.562000										HNSCC(75;0.22)			40	92					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81181901	81181901	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81181901G>A	ENST00000533478.1	-	0	2870				PKD1L2_ENST00000525539.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GGTTGATGGGGAACATGAGGA	0.552000													15	39					0	0	1	0	0
WBP1	23559	broad.mit.edu	37	2	74687629	74687629	+	Missense_Mutation	SNP	G	G	A	rs143637433	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74687629G>A	ENST00000393972.3	+	5	936	c.733G>A	c.(733-735)Gac>Aac	p.D245N	WBP1_ENST00000409737.1_Missense_Mutation_p.D208N|WBP1_ENST00000233615.2_Missense_Mutation_p.D211N|WBP1_ENST00000494741.1_3'UTR			Q96G27	WBP1_HUMAN	WW domain binding protein 1	211							WW domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	8						TTTAACTGGCGACTCCGGTAT	0.652000													76	150					0	0	1	0	0
NR5A1	2516	broad.mit.edu	37	9	127262788	127262788	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127262788C>A	ENST00000373588.4	-	4	647	c.451G>T	c.(451-453)Ggc>Tgc	p.G151C		NM_004959.4	NP_004950.2	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	151					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			lung(1)|upper_aerodigestive_tract(1)	2						GCGGCCAGGCCCTTGGGCTCA	0.741000													15	17					1.99824e-07	2.00394e-07	1	1	0
SEPT5	5413	broad.mit.edu	37	22	19709226	19709226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19709226C>T	ENST00000438754.2	+	8	1088	c.808C>T	c.(808-810)Cgg>Tgg	p.R270W	SEPT5_ENST00000383045.3_Missense_Mutation_p.R270W|SEPT5_ENST00000455784.2_Missense_Mutation_p.R261W|SEPT5_ENST00000406395.1_Missense_Mutation_p.R261W	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	261					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					GCAGCGGGTCCGGGGCCGACT	0.677000													42	65					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176520147	176520147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176520147C>T	ENST00000292408.4	+	9	1311	c.1066C>T	c.(1066-1068)Ccc>Tcc	p.P356S	FGFR4_ENST00000393648.2_Missense_Mutation_p.P356S|FGFR4_ENST00000393637.1_Intron|FGFR4_ENST00000502906.1_Missense_Mutation_p.P356S|FGFR4_ENST00000292410.3_Intron	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	356					insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	AGAGGAGGACCCCACATGGAC	0.652000										TSP Lung(9;0.080)			18	43					0	0	1	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10221747	10221747	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10221747C>T	ENST00000428358.1	+	12	1500	c.1328C>T	c.(1327-1329)tCc>tTc	p.S443F	PPAN_ENST00000393793.1_Missense_Mutation_p.S390F|PPAN_ENST00000253107.7_Missense_Mutation_p.S443F|PPAN-P2RY11_ENST00000393796.4_Intron|PPAN_ENST00000556468.1_Intron	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		443					RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			AAGGACAAGTCCCAGGGAGCC	0.687000													20	36					0	0	1	0	0
ENDOV	284131	broad.mit.edu	37	17	78399335	78399335	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78399335C>T	ENST00000518137.1	+	7	657	c.629C>T	c.(628-630)tCc>tTc	p.S210F	ENDOV_ENST00000522751.1_Missense_Mutation_p.S16F|ENDOV_ENST00000518901.1_Missense_Mutation_p.S16F|ENDOV_ENST00000518907.1_Missense_Mutation_p.S16F|ENDOV_ENST00000323854.5_Missense_Mutation_p.S165F|ENDOV_ENST00000517295.2_Missense_Mutation_p.S138F|ENDOV_ENST00000520367.1_Missense_Mutation_p.S165F|ENDOV_ENST00000520284.1_Missense_Mutation_p.S16F|ENDOV_ENST00000517795.1_Missense_Mutation_p.S16F	NM_173627.3	NP_775898.2	Q8N8Q3	ENDOV_HUMAN	endonuclease V	210					DNA repair		endodeoxyribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding			endometrium(1)|lung(1)|pancreas(1)|prostate(1)	4						CTCTACATCTCCGTGGGCCAC	0.692000								Direct reversal of damage					5	6					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153696708	153696708	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153696708C>T	ENST00000369682.3	+	23	4201	c.4026C>T	c.(4024-4026)ttC>ttT	p.F1342F		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1342					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCGCGCGTTCGTGCTTACCT	0.697000													14	10					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28193390	28193390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:28193390C>T	ENST00000302326.4	-	1	4096	c.3142G>A	c.(3142-3144)Gag>Aag	p.E1048K		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	1048							binding	p.E1048K(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						GTGCTCACCTCGTCCGAGGCG	0.627000			T	ETV6	"""AML, meningioma"""								7	98					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129704356	129704356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:129704356G>A	ENST00000421865.2	+	35	5098	c.5049G>A	c.(5047-5049)aaG>aaA	p.K1683K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1683	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AATTCATTAAGGAGCTTGCCC	0.458000													10	16					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16217068	16217068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:16217068C>T	ENST00000339732.5	+	1	913	c.410C>T	c.(409-411)gCt>gTt	p.A137V	GALNT15_ENST00000470031.1_3'UTR|GALNT15_ENST00000437509.1_Missense_Mutation_p.A137V	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		GACTGGGGGGCTGATGAGGAC	0.637000													16	22					0	0	1	0	0
OR51V1	283111	broad.mit.edu	37	11	5221755	5221755	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5221755C>T	ENST00000321255.1	-	1	175	c.176G>A	c.(175-177)tGg>tAg	p.W59*		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCTCAGTCCATATCACATG	0.532000													27	77					0	0	1	0	0
IER5L	389792	broad.mit.edu	37	9	131939645	131939645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131939645G>A	ENST00000372491.2	-	1	895	c.687C>T	c.(685-687)ccC>ccT	p.P229P	RP11-247A12.2_ENST00000372490.3_RNA|RP11-247A12.8_ENST00000599172.2_RNA	NM_203434.2	NP_982258.2	Q5T953	IER5L_HUMAN	immediate early response 5-like	229	Ala-rich.												Ovarian(14;0.0448)|Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		gggaggaggcgggggccgggg	0.771000													8	14					0	0	1	0	0
LHX3	8022	broad.mit.edu	37	9	139089520	139089520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139089520G>A	ENST00000371746.3	-	6	978	c.860C>T	c.(859-861)gCc>gTc	p.A287V	LHX3_ENST00000371748.5_Missense_Mutation_p.A282V	NM_014564.3	NP_055379.1	Q9UBR4	LHX3_HUMAN	LIM homeobox 3	282					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	8		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		CCGGCCCAAGGCCTGGGTGGG	0.677000													4	15					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580724	140580724	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580724C>T	ENST00000354757.3	+	1	1377	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	PCDHB11_ENST00000536699.1_Silent_p.F94F	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		459	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.587000													62	223					0	0	1	0	0
SLC22A3	6581	broad.mit.edu	37	6	160857870	160857870	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160857870C>T	ENST00000392145.1	+	6	1061	c.1034C>T	c.(1033-1035)cCc>cTc	p.P345L	SLC22A3_ENST00000275300.2_Missense_Mutation_p.P345L			O75751	S22A3_HUMAN	solute carrier family 22 (organic cation transporter), member 3	345						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		GTGAGAACTCCCCAAATGAGG	0.343000													26	25					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10083645	10083645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10083645G>A	ENST00000264828.3	-	51	3809	c.3724C>T	c.(3724-3726)Ccc>Tcc	p.P1242S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1242	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TTGCCTGGGGGTCCAGCAGCT	0.612000													5	25					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33579405	33579405	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:33579405G>A	ENST00000228567.3	-	2	473	c.177C>T	c.(175-177)gtC>gtT	p.V59V	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	59						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					AGCTGACAACGACAGCTAACA	0.363000													16	17					0	0	1	0	0
CPB1	1360	broad.mit.edu	37	3	148577674	148577674	+	Missense_Mutation	SNP	G	G	A	rs144356818		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:148577674G>A	ENST00000491148.1	+	12	1473	c.1139G>A	c.(1138-1140)cGa>cAa	p.R380Q	CPB1_ENST00000282957.4_Missense_Mutation_p.R380Q|CPB1_ENST00000498639.1_3'UTR|RP11-680B3.2_ENST00000488190.1_RNA			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	380					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TTTGAACTTCGAGATACAGGC	0.498000													28	88					0	0	1	0	0
TRIM6	117854	broad.mit.edu	37	11	5626711	5626711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5626711G>A	ENST00000380097.3	+	4	990	c.748G>A	c.(748-750)Gat>Aat	p.D250N	TRIM6_ENST00000506134.1_Missense_Mutation_p.D47N|TRIM6-TRIM34_ENST00000354852.5_Missense_Mutation_p.D250N|TRIM6_ENST00000445329.1_Missense_Mutation_p.D47N|TRIM6_ENST00000380107.1_Missense_Mutation_p.D196N|TRIM6_ENST00000278302.5_Missense_Mutation_p.D222N|TRIM6_ENST00000515022.1_Missense_Mutation_p.D47N|HBG2_ENST00000380259.2_Intron|TRIM6_ENST00000507320.1_Missense_Mutation_p.D47N|AC015691.13_ENST00000394793.2_RNA	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		GGCTGAGAATGATCTGGTCCA	0.522000											OREG0003723	type=REGULATORY REGION|Gene=TRIM6|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	20	56					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532323	40532323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:40532323C>T	ENST00000297737.6	-	5	623	c.477G>A	c.(475-477)atG>atA	p.M159I	ZMAT4_ENST00000315769.7_Intron	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	159						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			GTTGCTGGGCCATCAGAGGGT	0.493000													46	204					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540842	55540842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55540842C>T	ENST00000220676.1	+	4	4548	c.4400C>T	c.(4399-4401)tCt>tTt	p.S1467F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1467					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GAATTGGAATCTTTTGAAGAA	0.378000													14	70					0	0	1	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967526	142967526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142967526G>A	ENST00000370494.1	+	1	354	c.324G>A	c.(322-324)tcG>tcA	p.S108S		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	108							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					TTCTGCTATCGATCCAGGCCT	0.423000													70	47					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128797335	128797335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128797335G>A	ENST00000274487.4	+	2	759	c.614G>A	c.(613-615)gGg>gAg	p.G205E		NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	205	Pro-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GGCCCCACGGGGGCAGCATCC	0.701000													12	29					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71747977	71747977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71747977G>A	ENST00000258104.3	+	11	1273	c.996G>A	c.(994-996)ggG>ggA	p.G332G	DYSF_ENST00000394120.2_Silent_p.G333G|DYSF_ENST00000409744.1_Silent_p.G333G|DYSF_ENST00000410020.3_Silent_p.G364G|DYSF_ENST00000413539.2_Silent_p.G363G|DYSF_ENST00000429174.2_Silent_p.G332G|DYSF_ENST00000409366.1_Silent_p.G333G|DYSF_ENST00000409582.3_Silent_p.G363G|DYSF_ENST00000409762.1_Silent_p.G363G|DYSF_ENST00000409651.1_Silent_p.G364G|DYSF_ENST00000410041.1_Silent_p.G364G	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	332						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TCTCTGCTGGGGCCAGAGGCT	0.572000													27	92					0	0	1	0	0
GCM2	9247	broad.mit.edu	37	6	10876198	10876198	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:10876198C>T	ENST00000379491.4	-	4	655	c.508G>A	c.(508-510)Gct>Act	p.A170T	RP11-637O19.3_ENST00000480294.1_Intron|SYCP2L_ENST00000543878.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	170					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				CTTCTTCTAGCTTCTGTCTCT	0.453000													32	83					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803443	23803443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:23803443C>T	ENST00000264867.2	-	12	2322	c.2203G>A	c.(2203-2205)Gga>Aga	p.G735R	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	735	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				AAAGTGTATCCATTTTCAAGA	0.408000													4	49					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118969759	118969759	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:118969759G>A	ENST00000328252.3	+	3	1872	c.1503G>A	c.(1501-1503)ctG>ctA	p.L501L	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	501	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TTAATGAGCTGAAGAACATTC	0.413000													22	72					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059419	248059419	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248059419C>T	ENST00000537741.1	+	3	788	c.531C>T	c.(529-531)ttC>ttT	p.F177F	OR2W3_ENST00000360358.3_Silent_p.F177F			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGGACCACTTCCTGCGTGAGA	0.647000													18	94					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997965	115997965	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:115997965C>T	ENST00000264363.2	-	2	906	c.228G>A	c.(226-228)acG>acA	p.T76T		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	76	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CAGTAGGGTCCGTTTTGGATG	0.418000													41	81					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72351061	72351061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72351061C>T	ENST00000389916.4	+	19	2985	c.2847C>T	c.(2845-2847)ctC>ctT	p.L949L		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	949					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						AAGTCAAACTCCCTCCAAGCC	0.612000													3	7					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1657262	1657262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1657262G>A	ENST00000426508.2	-	3	369	c.6C>T	c.(4-6)gcC>gcT	p.A2A	LA16c-395F10.2_ENST00000563162.1_RNA|IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	2										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				CATAATAGAGGGCCATGACGG	0.468000													27	80					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120969584	120969584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120969584C>T	ENST00000273666.6	+	15	1686	c.1415C>T	c.(1414-1416)tCa>tTa	p.S472L	STXBP5L_ENST00000471454.1_Missense_Mutation_p.S472L|STXBP5L_ENST00000492541.1_Missense_Mutation_p.S472L|STXBP5L_ENST00000497029.1_Missense_Mutation_p.S472L|STXBP5L_ENST00000472879.1_Missense_Mutation_p.S472L	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	472					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		GCAGATGGATCAATAAAATTT	0.294000													12	33					0	0	1	0	0
MINK1	50488	broad.mit.edu	37	17	4791003	4791003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4791003C>T	ENST00000355280.6	+	12	1344	c.1148C>T	c.(1147-1149)cCc>cTc	p.P383L	MINK1_ENST00000453408.3_Missense_Mutation_p.P383L|MINK1_ENST00000347992.7_Missense_Mutation_p.P383L	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	383					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						cagcGAGACCCCGAGGCACAC	0.617000													4	2					0	0	1	0	0
IL1B	3553	broad.mit.edu	37	2	113588899	113588899	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113588899C>T	ENST00000263341.2	-	6	777	c.567G>A	c.(565-567)ttG>ttA	p.L189L	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	189					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	TATCATCTTTCAACACGCAGG	0.468000													69	166					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54894327	54894327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54894327G>A	ENST00000293373.6	+	3	303	c.224G>A	c.(223-225)gGa>gAa	p.G75E	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.G25E	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	75					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CAACATTTAGGACCAGTACAT	0.373000													57	139					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15547702	15547702	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15547702G>A	ENST00000389282.4	-	4	2724	c.2511C>T	c.(2509-2511)ttC>ttT	p.F837F	WIZ_ENST00000263381.6_Silent_p.F148F|WIZ_ENST00000595214.2_5'UTR			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	837						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						GGGAGGTCAGGAAGCTGCCAG	0.682000													7	29					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1387776	1387776	+	Missense_Mutation	SNP	C	C	T	rs144852834	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1387776C>T	ENST00000378785.2	+	3	1179	c.184C>T	c.(184-186)Cgt>Tgt	p.R62C		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	62							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGAAGGATTCCGTGCCTTTGT	0.577000													33	85					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24902212	24902212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24902212G>A	ENST00000347898.3	+	9	1309	c.687G>A	c.(685-687)atG>atA	p.M229I	SLC5A11_ENST00000449109.2_Intron|SLC5A11_ENST00000565769.1_Missense_Mutation_p.M165I|SLC5A11_ENST00000545376.1_Missense_Mutation_p.M159I|SLC5A11_ENST00000539472.1_Missense_Mutation_p.M165I|SLC5A11_ENST00000568579.1_Missense_Mutation_p.M159I|SLC5A11_ENST00000569071.1_Intron|SLC5A11_ENST00000424767.2_Missense_Mutation_p.M194I|SLC5A11_ENST00000567758.1_Missense_Mutation_p.M194I	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	229					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		TTGGTGGGATGGAAGGACTGA	0.547000													53	164					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41949551	41949551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41949551C>T	ENST00000298919.7	+	7	962	c.574C>T	c.(574-576)Cgg>Tgg	p.R192W	PDZRN4_ENST00000402685.2_Missense_Mutation_p.R452W|PDZRN4_ENST00000539469.2_Missense_Mutation_p.R194W			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	452							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AGAAGGGGATCGGATTTTGCA	0.408000													19	106					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48312324	48312324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48312324C>T	ENST00000435803.1	+	17	3085	c.3061C>T	c.(3061-3063)Ctt>Ttt	p.L1021F		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1021					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AGCAGAGGTTCTTGGGGGAAT	0.343000													9	18					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16894480	16894480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16894480C>T	ENST00000430580.2	-	24	3547	c.2660G>A	c.(2659-2661)gGt>gAt	p.G887D	NBPF1_ENST00000432949.1_Silent_p.R290R|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	887	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCACCTGGGACCTGTTGCCTC	0.438000													39	487					0	0	1	0	0
LUC7L3	51747	broad.mit.edu	37	17	48823102	48823102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48823102G>A	ENST00000505658.1	+	8	904	c.715G>A	c.(715-717)Gaa>Aaa	p.E239K	LUC7L3_ENST00000240304.1_Missense_Mutation_p.E239K|LUC7L3_ENST00000393227.2_Missense_Mutation_p.E239K|LUC7L3_ENST00000544170.1_Missense_Mutation_p.E163K			O95232	LC7L3_HUMAN	LUC7-like 3 (S. cerevisiae)	239	Arg/Ser-rich.|Glu-rich.				apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	12						GAAAAGAACCGAAGAACCTGA	0.348000													6	49					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120385964	120385964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120385964G>A	ENST00000331113.4	+	5	2563	c.1598G>A	c.(1597-1599)cGa>cAa	p.R533Q		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	533					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TGTTCACGACGACACAAAAAA	0.448000													35	84					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201687649	201687649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201687649C>T	ENST00000367296.4	+	3	1412	c.992C>T	c.(991-993)cCc>cTc	p.P331L	IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367302.1_Missense_Mutation_p.P344L|NAV1_ENST00000295624.6_Missense_Mutation_p.P331L|NAV1_ENST00000367300.3_Missense_Mutation_p.P331L|NAV1_ENST00000367297.4_Missense_Mutation_p.P331L	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	331					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						GGTGACGCGCCCTCTGTGGGT	0.697000													13	26					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885322	24885322	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24885322G>A	ENST00000382554.3	+	9	4685	c.4367G>A	c.(4366-4368)tGg>tAg	p.W1456*		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1456					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GGGCAGTGGTGGAGTTTGCCA	0.602000													25	40					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065620	55065620	+	RNA	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55065620G>C	ENST00000526016.1	-	0	88					NR_038174.2																						TGTCTTGCCAGTTGAGGTAGA	0.493000													15	47					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5664387	5664387	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5664387G>A	ENST00000354852.5	+	14	2150	c.1977G>A	c.(1975-1977)ctG>ctA	p.L659L	HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000495668.1_3'UTR|TRIM34_ENST00000514226.1_Silent_p.L305L|TRIM34_ENST00000429814.2_Silent_p.L305L|TRIM6-TRIM34_ENST00000457787.2_Silent_p.L305L	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		659						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		ATGTCACACTGAATTCAGTCA	0.318000													6	14					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48598515	48598515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48598515C>T	ENST00000323776.5	+	8	1252	c.1090C>T	c.(1090-1092)Cgg>Tgg	p.R364W	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.R327W	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	327					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CACCTGGGATCGGAGTCTGTT	0.567000													10	20					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108813853	108813853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108813853C>T	ENST00000232603.5	-	7	568	c.486G>A	c.(484-486)caG>caA	p.Q162Q	MORC1_ENST00000483760.1_Silent_p.Q162Q	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	162					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTGCAAATTTCTGGGGATCAT	0.323000													17	54					0	0	1	0	0
CD6	923	broad.mit.edu	37	11	60785797	60785797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60785797C>T	ENST00000313421.7	+	12	2060	c.1874C>T	c.(1873-1875)tCc>tTc	p.S625F	CD6_ENST00000352009.5_Intron|CD6_ENST00000346437.4_Missense_Mutation_p.S552F|CD6_ENST00000344028.5_Missense_Mutation_p.S593F|CD6_ENST00000452451.2_Intron	NM_006725.4	NP_006716.3	P30203	CD6_HUMAN	CD6 molecule	625					cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)	18						AGCACCTCATCCGGGGAGTGG	0.622000													8	19					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14791399	14791399	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14791399G>A	ENST00000358984.4	+	16	1914		c.e16-1		ANKRD30B_ENST00000447268.2_Splice_Site|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B											breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ACTTTTAACAGAGTCCCTGTG	0.299000													13	72					0	0	1	0	0
PRTFDC1	56952	broad.mit.edu	37	10	25226182	25226182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25226182C>T	ENST00000320152.6	-	3	298	c.270G>A	c.(268-270)aaG>aaA	p.K90K	PRTFDC1_ENST00000376376.3_Silent_p.K90K|PRTFDC1_ENST00000376378.1_Silent_p.K90K	NM_020200.5	NP_064585.1	Q9NRG1	PRDC1_HUMAN	phosphoribosyl transferase domain containing 1	90					adenine salvage|central nervous system neuron development|cerebral cortex neuron differentiation|cytolysis|dendrite morphogenesis|GMP salvage|grooming behavior|hypoxanthine metabolic process|IMP salvage|lymphocyte proliferation|positive regulation of dopamine metabolic process|purine ribonucleoside salvage|response to amphetamine|striatum development	cytosol	hypoxanthine phosphoribosyltransferase activity|magnesium ion binding|nucleotide binding|protein homodimerization activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	9						GGCTGATGTTCTTAAGGTGTT	0.373000													36	83					0	0	1	0	0
IPO9	55705	broad.mit.edu	37	1	201840306	201840306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201840306C>T	ENST00000361565.4	+	19	2496	c.2427C>T	c.(2425-2427)ttC>ttT	p.F809F		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	809					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						TCATGGTGTTCGCTCATCTGG	0.483000													55	134					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179737040	179737040	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179737040C>T	ENST00000420890.2	-	13	2017		c.e13-1		CCDC141_ENST00000295723.5_Splice_Site	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141								protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TCTCTTTTGCCTGTTAAATTA	0.338000													18	50					0	0	1	0	0
GPR22	2845	broad.mit.edu	37	7	107115577	107115577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107115577G>A	ENST00000304402.4	+	3	2415	c.1072G>A	c.(1072-1074)Gga>Aga	p.G358R	COG5_ENST00000297135.3_Intron|COG5_ENST00000393603.2_Intron|COG5_ENST00000347053.3_Intron|COG5_ENST00000475638.2_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	358						integral to plasma membrane	G-protein coupled receptor activity			large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						CATGGCTTATGGAACAACTAT	0.313000													40	92					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110829374	110829374	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110829374G>A	ENST00000375820.4	-	34	2848	c.2727C>T	c.(2725-2727)ggC>ggT	p.G909G		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	909	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGCCCGGAAAGCCATGGTCCC	0.592000													18	49					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587231	247587231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247587231G>A	ENST00000366497.2	+	4	1266	c.486G>A	c.(484-486)gtG>gtA	p.V162V	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Silent_p.V162V|NLRP3_ENST00000336119.3_Silent_p.V162V|NLRP3_ENST00000348069.2_Silent_p.V162V|NLRP3_ENST00000391828.3_Silent_p.V162V|NLRP3_ENST00000391827.2_Silent_p.V162V	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	162					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GTGAGAGTGTGAGCCTCAACA	0.532000													8	31					0	0	1	0	0
PDZD7	79955	broad.mit.edu	37	10	102789950	102789950	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102789950G>A	ENST00000370215.3	-	2	252	c.27C>T	c.(25-27)ttC>ttT	p.F9F	PDZD7_ENST00000470414.1_Silent_p.F9F	NM_024895.4	NP_079171.1	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	9						cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CCAGTGGGTCGAAGCCCACTG	0.667000													4	16					0	0	1	0	0
DCST2	127579	broad.mit.edu	37	1	155002584	155002584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155002584C>T	ENST00000368424.3	-	7	1211	c.1153G>A	c.(1153-1155)Gag>Aag	p.E385K	DCST2_ENST00000295536.5_Missense_Mutation_p.E385K	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	385						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CGCCTGGCCTCGTGAGCACTG	0.652000													27	57					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40566414	40566414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40566414C>T	ENST00000560346.1	+	10	2398	c.1815C>T	c.(1813-1815)tcC>tcT	p.S605S	PAK6_ENST00000441369.1_Silent_p.S605S|PAK6_ENST00000453867.1_Silent_p.S605S|PAK6_ENST00000542403.2_Silent_p.S605S|PAK6_ENST00000455577.2_Intron|RP11-133K1.2_ENST00000558658.1_3'UTR|PAK6_ENST00000260404.4_Silent_p.S605S			Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	605	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		TCAGTGACTCCCCAGTGCAAG	0.572000											OREG0023057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	104					0	0	1	0	0
SLC29A3	55315	broad.mit.edu	37	10	73104007	73104007	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73104007C>A	ENST00000373189.5	+	3	394	c.342C>A	c.(340-342)ccC>ccA	p.P114P		NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	114					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						CCACCGTGCCCTCCATGCTGT	0.587000													25	64					2.41591e-17	2.42983e-17	1	1	0
MOV10	4343	broad.mit.edu	37	1	113234340	113234340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113234340C>T	ENST00000369644.1	+	7	1751	c.722C>T	c.(721-723)cCt>cTt	p.P241L	MOV10_ENST00000413052.2_Missense_Mutation_p.P297L|MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000357443.2_Missense_Mutation_p.P297L|MOV10_ENST00000369645.1_Missense_Mutation_p.P297L			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	297					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TACTACCCACCTCCCCGCCTC	0.542000													33	96					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269119	30269119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:30269119C>T	ENST00000378981.3	+	4	830	c.509C>T	c.(508-510)cCt>cTt	p.P170L	MAGEB1_ENST00000397550.1_Missense_Mutation_p.P170L|MAGEB1_ENST00000397548.2_Missense_Mutation_p.P170L	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	170	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						GAAGACAACCCTAGTGGCCAC	0.493000													10	8					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4827821	4827821	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4827821C>T	ENST00000268231.8	-	10	1317	c.1054G>A	c.(1054-1056)Gac>Aac	p.D352N	SEPT12_ENST00000396693.5_Missense_Mutation_p.D306N	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	352					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						TCAGAATCGTCATGGGCCCCC	0.672000													3	4					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32264549	32264549	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32264549G>A	ENST00000343380.5	-	7	1442	c.1303C>T	c.(1303-1305)Ctg>Ttg	p.L435L		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	435	Transactivation.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						CAGAAATCCAGGGGGGTGAGG	0.642000													3	14					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330444	125330444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125330444G>A	ENST00000304865.2	-	1	394	c.313C>T	c.(313-315)Ctc>Ttc	p.L105F		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						AAGGCATAGAGAAAATACATC	0.488000													28	52					0	0	1	0	0
ELL	8178	broad.mit.edu	37	19	18572511	18572511	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18572511G>A	ENST00000262809.4	-	5	692	c.621C>T	c.(619-621)ttC>ttT	p.F207F		NM_006532.3	NP_006523.1	P55199	ELL_HUMAN	elongation factor RNA polymerase II	207					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(5)|prostate(1)	19				GBM - Glioblastoma multiforme(1328;7.81e-07)		CTCGGTCACGGAAGGGCCTCT	0.672000			T	MLL	AL						OREG0025366	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	52					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103311564	103311564	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103311564G>A	ENST00000233969.2	+	7	1720	c.1578G>A	c.(1576-1578)tgG>tgA	p.W526*	SLC9A2_ENST00000469286.1_3'UTR	NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	526						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						ACAACTTTTGGAGAGACAAGT	0.368000													39	156					0	0	1	0	0
CSE1L	1434	broad.mit.edu	37	20	47700684	47700684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47700684C>T	ENST00000262982.2	+	15	1727	c.1604C>T	c.(1603-1605)cCt>cTt	p.P535L	CSE1L_ENST00000396192.3_Missense_Mutation_p.P479L|CSE1L_ENST00000542325.1_Missense_Mutation_p.P318L	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	535					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			ATGCGAGGGCCTAACAATGCC	0.403000													18	109					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35910131	35910131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35910131C>T	ENST00000397367.2	-	4	488	c.362G>A	c.(361-363)aGa>aAa	p.R121K	CAPSL_ENST00000514524.1_Missense_Mutation_p.R121K|CAPSL_ENST00000397366.1_Missense_Mutation_p.R121K	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	121	EF-hand 3.					cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			GTCTAACTTTCTAAAAGCTTG	0.378000													29	96					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112732956	112732956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:112732956G>A	ENST00000295408.4	+	7	1308	c.1051G>A	c.(1051-1053)Gcc>Acc	p.A351T	MERTK_ENST00000421804.2_Missense_Mutation_p.A351T|MERTK_ENST00000409780.1_Missense_Mutation_p.A175T			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	351	Fibronectin type-III 1.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						GCAGCTGCAAGCCCTGGCTAA	0.473000													63	142					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	425526	425526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:425526G>A	ENST00000256509.2	+	19	2846	c.2204G>A	c.(2203-2205)aGg>aAg	p.R735K	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Missense_Mutation_p.R719K	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	719	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAAAACATAAGGGTTCAAGCC	0.353000													28	72					0	0	1	0	0
TSSK4	283629	broad.mit.edu	37	14	24675162	24675162	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24675162A>G	ENST00000339917.5	+	1	237	c.33A>G	c.(31-33)ccA>ccG	p.P11P	TSSK4_ENST00000428351.2_Silent_p.P11P|TM9SF1_ENST00000556387.1_Intron|TSSK4_ENST00000556621.1_Intron|TM9SF1_ENST00000530611.1_Intron|TSSK4_ENST00000287913.6_Silent_p.P11P	NM_001184739.1|NM_174944.3	NP_001171668.1|NP_777604.2	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	11					cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	8				GBM - Glioblastoma multiforme(265;0.018)		AGGCAGCACCAACCACCACAG	0.522000													16	64					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232666	21232666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21232666C>T	ENST00000233242.1	-	26	7201	c.7074G>A	c.(7072-7074)atG>atA	p.M2358I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2358					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTAATTTATCCATTAAAACCT	0.373000													14	60					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153417432	153417432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:153417432G>A	ENST00000288670.9	+	6	846	c.479G>A	c.(478-480)aGc>aAc	p.S160N		NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	160	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						ACTGTGGAGAGCTCGGTGGAC	0.473000													6	14					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36952410	36952410	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36952410G>A	ENST00000262865.4	+	8	996	c.907G>A	c.(907-909)Gag>Aag	p.E303K	CTD-2308N23.2_ENST00000437016.1_RNA|BPI_ENST00000489102.1_3'UTR	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	303					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				TGTATACCAAGAGGCTGGGGT	0.562000													11	43					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13366056	13366056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13366056G>A	ENST00000360228.5	-	29	4607	c.4608C>T	c.(4606-4608)ttC>ttT	p.F1536F	CACNA1A_ENST00000573710.2_Silent_p.F1537F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1537					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGCTGATGGCGAAATCAATGC	0.612000													4	16					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78846280	78846280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:78846280G>A	ENST00000286627.5	-	11	2358	c.1406C>T	c.(1405-1407)tCc>tTc	p.S469F	KCNMA1_ENST00000404857.1_Missense_Mutation_p.S469F|KCNMA1_ENST00000372443.1_Missense_Mutation_p.S469F|KCNMA1_ENST00000286628.8_Missense_Mutation_p.S469F|KCNMA1_ENST00000372440.1_Missense_Mutation_p.S469F|KCNMA1_ENST00000354353.5_Missense_Mutation_p.S469F|KCNMA1_ENST00000406533.3_Missense_Mutation_p.S469F|KCNMA1_ENST00000404771.3_Missense_Mutation_p.S469F	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	469	RCK N-terminal.				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	ATTGAGGACGGAACCCTGATA	0.473000													20	56					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126224649	126224649	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126224649G>A	ENST00000290868.2	-	8	761	c.708C>T	c.(706-708)atC>atT	p.I236I	UROC1_ENST00000383579.3_Silent_p.I236I	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	236					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CCAAGTCCTCGATGCCCAGGT	0.647000													15	41					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128855915	128855915	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128855915G>A	ENST00000310343.9	-	14	1466	c.1467C>T	c.(1465-1467)ctC>ctT	p.L489L	ARHGAP32_ENST00000527272.1_Silent_p.L140L|ARHGAP32_ENST00000392657.3_Silent_p.L140L|ARHGAP32_ENST00000524655.1_Silent_p.L415L	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	489	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GTGGTGGGGGGAGCTGCTGGA	0.438000													8	35					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24533775	24533775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24533775G>A	ENST00000357578.3	+	10	1588	c.1443G>A	c.(1441-1443)gtG>gtA	p.V481V	ALDH5A1_ENST00000348925.2_Silent_p.V494V|ALDH5A1_ENST00000491546.1_Silent_p.V453V|ALDH5A1_ENST00000546278.1_Silent_p.V393V	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	481					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TCTGGAGAGTGGCAGAGCAGC	0.488000													32	97					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50144242	50144242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50144242C>T	ENST00000347869.3	+	11	1073	c.898C>T	c.(898-900)Cct>Tct	p.P300S		NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	300	RRM 2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTCCATCCTCCTTTGAAAAT	0.388000													33	74					0	0	1	0	0
TBX21	30009	broad.mit.edu	37	17	45820503	45820503	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45820503C>T	ENST00000177694.1	+	3	924	c.713C>T	c.(712-714)tCa>tTa	p.S238L		NM_013351.1	NP_037483.1	Q9UL17	TBX21_HUMAN	T-box 21	238					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(1)|endometrium(1)|large_intestine(3)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	22						CAGGAAGTTTCATTTGGGAAA	0.572000													23	44					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964834	119964834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119964834G>A	ENST00000543831.1	+	4	959	c.710G>A	c.(709-711)aGg>aAg	p.R237K	HSD3B2_ENST00000369416.3_Missense_Mutation_p.R237K	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	237			Missing (in AH2; activity abolished).		androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CTGGCCTTGAGGGCTCTGCGG	0.507000													12	94					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53201637	53201637	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53201637A>G	ENST00000293774.4	-	7	1629	c.1359T>C	c.(1357-1359)ctT>ctC	p.L453L	KRT4_ENST00000458244.2_Silent_p.L359L|KRT4_ENST00000551956.1_Silent_p.L379L			B4DRS2	B4DRS2_HUMAN	keratin 4	379						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CGGATACCTGAAGAGTCTGGC	0.577000													6	51					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167504	140167504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140167504G>A	ENST00000458420.3	+	6	1121	c.931G>A	c.(931-933)Gac>Aac	p.D311N		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	311					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GAAGGGTTGTGACCGGGAGAC	0.463000										HNSCC(16;0.037)			36	93					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255505	15255505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15255505C>T	ENST00000378116.4	-	8	2088	c.2082G>A	c.(2080-2082)atG>atA	p.M694I		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	694						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CCCCAAGCTCCATCAGGGCCT	0.582000													37	89					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89789189	89789189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89789189C>T	ENST00000289816.5	+	2	543	c.231C>T	c.(229-231)tcC>tcT	p.S77S	ZNF276_ENST00000443381.2_Silent_p.S152S|ZNF276_ENST00000568064.1_Silent_p.S77S|ZNF276_ENST00000446326.2_5'UTR	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TTCTCAAGTCCTTCCTGCAGA	0.607000													40	79					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26663466	26663466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26663466G>A	ENST00000256737.3	+	22	3017	c.2165G>A	c.(2164-2166)cGa>cAa	p.R722Q	ANO3_ENST00000537978.1_Missense_Mutation_p.R706Q|ANO3_ENST00000531568.1_Missense_Mutation_p.R576Q|ANO3_ENST00000525139.1_Missense_Mutation_p.R706Q	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	722						chloride channel complex	chloride channel activity	p.R722Q(1)		breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						TGGTGGTCACGACATAAAATC	0.428000													22	88					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760565	92760565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92760565C>T	ENST00000318238.4	-	5	5936	c.4720G>A	c.(4720-4722)Gaa>Aaa	p.E1574K	SAMD9L_ENST00000411955.1_Missense_Mutation_p.E1574K|SAMD9L_ENST00000437805.1_Missense_Mutation_p.E1574K	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1574										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGAGGGCCTTCAATGGAAAAT	0.323000													21	51					0	0	1	0	0
BCMO1	53630	broad.mit.edu	37	16	81319226	81319226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81319226C>T	ENST00000258168.2	+	9	1750	c.1289C>T	c.(1288-1290)cCa>cTa	p.P430L	BCMO1_ENST00000425577.2_Missense_Mutation_p.P361L	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	430					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						CAGTGGAGTCCAATCCCAACC	0.438000													8	61					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62757842	62757842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:62757842C>T	ENST00000281156.4	-	3	555	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	93	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		CCTGTTTCTTCCTGTAGCCTC	0.373000													42	143					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504631	70504631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70504631G>A	ENST00000310961.5	+	22	3443	c.3025G>A	c.(3025-3027)Gat>Aat	p.D1009N	LRRC7_ENST00000415775.2_Missense_Mutation_p.D288N|LRRC7_ENST00000035383.5_Missense_Mutation_p.D1004N			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1004						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCCAATGCTGGATGATGAGAT	0.468000													16	55					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240849	126240849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126240849G>A	ENST00000394329.3	+	1	3296	c.3283G>A	c.(3283-3285)Gat>Aat	p.D1095N		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1095	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGATGTAAATGATAACAGACC	0.383000													72	177					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127777	152127777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152127777C>T	ENST00000316073.3	-	3	1862	c.1798G>A	c.(1798-1800)Ggg>Agg	p.G600R		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	600	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CCTTCAGTCCCTTGGAAGTAC	0.458000													102	263					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33700343	33700343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33700343G>A	ENST00000336934.5	-	7	2073	c.1957C>T	c.(1957-1959)Ccc>Tcc	p.P653S	STARD13_ENST00000255486.4_Missense_Mutation_p.P645S|STARD13_ENST00000399365.3_Missense_Mutation_p.P535S	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	653					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TTGTAGTCGGGAACTTTCATC	0.498000													61	162					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60212997	60212997	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:60212997G>A	ENST00000267484.5	-	2	779	c.444C>T	c.(442-444)ccC>ccT	p.P148P		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	148					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		CTGGTAAGGAGGGGCCGGGTG	0.488000													17	52					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286797	152286797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152286797C>T	ENST00000368799.1	-	3	600	c.565G>A	c.(565-567)Gaa>Aaa	p.E189K	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	189					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTAGTATTTTCAGTCTTGTTT	0.308000									Ichthyosis				9	80					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140043562	140043562	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140043562G>A	ENST00000371561.3	+	4	1768		c.e4+1		GRIN1_ENST00000350902.5_Splice_Site|GRIN1_ENST00000371555.4_Splice_Site|GRIN1_ENST00000315048.3_Splice_Site|GRIN1_ENST00000371560.3_Splice_Site|GRIN1_ENST00000371559.4_Splice_Site|GRIN1_ENST00000371546.4_Splice_Site|GRIN1_ENST00000371550.4_Splice_Site|GRIN1_ENST00000471122.1_Splice_Site|GRIN1_ENST00000371553.3_Splice_Site	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1						ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	TTTCTGCCAGGTGAGGCTGGG	0.602000													7	9					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110821999	110821999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110821999C>T	ENST00000375820.4	-	43	3974	c.3853G>A	c.(3853-3855)Gac>Aac	p.D1285N		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1285	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AATCCAGGGTCTCCCTTGGGC	0.498000													8	120					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6955364	6955364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6955364G>A	ENST00000389658.3	-	57	8288	c.8195C>T	c.(8194-8196)gCt>gTt	p.A2732V	RP11-781P6.1_ENST00000584722.1_RNA	NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2732	Laminin G-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTTTCTGACAGCCGACTGATT	0.478000													4	28					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143772241	143772241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143772241C>T	ENST00000408898.2	+	1	967	c.929C>T	c.(928-930)tCa>tTa	p.S310L		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					AAGAGAACTTCATGAAAGCCT	0.398000													63	176					0	0	1	0	0
WNT5B	81029	broad.mit.edu	37	12	1755004	1755004	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1755004C>T	ENST00000397196.2	+	5	898	c.666C>T	c.(664-666)gtC>gtT	p.V222V	WNT5B_ENST00000537031.1_Silent_p.V222V|WNT5B_ENST00000542408.1_3'UTR|WNT5B_ENST00000310594.3_Silent_p.V222V|WNT5B_ENST00000545747.1_3'UTR	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	222					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			GCCACGGCGTCTCGGGGTCCT	0.617000													18	78					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98312019	98312019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98312019G>A	ENST00000264193.2	-	1	548	c.330C>T	c.(328-330)gcC>gcT	p.A110A		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	110						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CCAGCGAAGTGGCCCGCGTCC	0.726000													8	15					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740549	37740549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37740549C>T	ENST00000539465.1	+	15	2617	c.2024C>T	c.(2023-2025)tCc>tTc	p.S675F	FRMPD1_ENST00000541302.1_Missense_Mutation_p.S544F|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000536622.1_Missense_Mutation_p.S497F|FRMPD1_ENST00000377765.3_Missense_Mutation_p.S675F			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	675						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		ACAGAGTTTTCCGAGAGTGCT	0.582000													6	37					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106110258	106110258	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106110258G>A	ENST00000390545.2	-	0	359																											GGGGGAAGAGGAAGACTGACG	0.622000													23	78					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32059435	32059435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:32059435C>T	ENST00000438447.1	+	13	2679	c.2291C>T	c.(2290-2292)tCa>tTa	p.S764L	PDZD2_ENST00000282493.3_Missense_Mutation_p.S764L			O15018	PDZD2_HUMAN	PDZ domain containing 2	764	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GCTCCAGGATCAGTGGCCAAG	0.463000													26	39					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130409573	130409573	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130409573C>T	ENST00000370904.1	-	22	3946	c.3036G>A	c.(3034-3036)ggG>ggA	p.G1012G	IGSF1_ENST00000370903.3_Silent_p.G1026G|IGSF1_ENST00000370910.1_Silent_p.G1012G|IGSF1_ENST00000361420.3_Silent_p.G1021G			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1021	Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TGGGGAATGCCCCGTCATTAC	0.522000													10	42					0	0	1	0	0
CLEC7A	64581	broad.mit.edu	37	12	10275908	10275908	+	Missense_Mutation	SNP	G	G	A	rs140318683	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10275908G>A	ENST00000353231.5	-	4	567	c.409C>T	c.(409-411)Ctt>Ttt	p.L137F	CLEC7A_ENST00000304084.8_Missense_Mutation_p.L183F|CLEC7A_ENST00000298523.5_Intron|CLEC7A_ENST00000533022.1_Intron|CLEC7A_ENST00000396484.2_Missense_Mutation_p.L104F	NM_022570.4	NP_072092.2	Q9BXN2	CLC7A_HUMAN	C-type lectin domain family 7, member A	183	C-type lectin.				carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						GGCCGAGAAAGGCCTATCCAA	0.388000													10	48					0	0	1	0	0
GPR176	11245	broad.mit.edu	37	15	40099395	40099395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40099395G>A	ENST00000299092.3	-	3	432	c.234C>T	c.(232-234)ttC>ttT	p.F78F	GPR176_ENST00000543580.1_Silent_p.F34F|GPR176_ENST00000560729.1_5'UTR|GPR176_ENST00000561100.1_Silent_p.F79F	NM_001271854.1|NM_001271855.1	NP_001258783.1|NP_001258784.1	Q14439	GP176_HUMAN	G protein-coupled receptor 176	79					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)	23		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		GGTTTTTAATGAACCTGTTGG	0.453000													52	121					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36402445	36402445	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36402445C>T	ENST00000255448.4	-	9	1441		c.e9-1		DCLK1_ENST00000379893.1_Splice_Site|DCLK1_ENST00000360631.3_Splice_Site	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1						cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		AGCAGTCGATCTGCGAAGAGA	0.323000													15	29					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85518140	85518140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:85518140G>A	ENST00000393217.2	+	17	3911	c.3850G>A	c.(3850-3852)Gaa>Aaa	p.E1284K		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1284										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CGCCACATGTGAAAATATGGA	0.448000													66	121					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184175043	184175043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:184175043C>T	ENST00000403733.3	+	9	1286	c.1087C>T	c.(1087-1089)Cca>Tca	p.P363S	WWC2_ENST00000504005.1_Missense_Mutation_p.P45S|WWC2_ENST00000448232.2_Missense_Mutation_p.P363S|WWC2_ENST00000378925.3_Missense_Mutation_p.P265S|WWC2_ENST00000513834.1_Missense_Mutation_p.P363S	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	363										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		GTTCGTCACCCCACAGAAACG	0.483000													4	24					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3658762	3658762	+	Silent	SNP	C	C	T	rs146442815		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:3658762C>T	ENST00000404826.2	+	2	488	c.349C>T	c.(349-351)Ctg>Ttg	p.L117L	SDK1_ENST00000389531.3_Silent_p.L117L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	117	Ig-like C2-type 1.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACAGATCCACCTGGAAGGGAA	0.473000													12	24					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101748012	101748012	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101748012G>A	ENST00000375001.3	+	3	689	c.266G>A	c.(265-267)aGg>aAg	p.R89K		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	89	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				ACCTTCTTCAGGGACTTCGCC	0.612000													11	57					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72360381	72360381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72360381G>A	ENST00000441259.1	-	2	438	c.278C>T	c.(277-279)aCc>aTc	p.T93I	PRF1_ENST00000373209.2_Missense_Mutation_p.T93I	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	93	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						CCGCCAGTTGGTGAGCGCCAG	0.662000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				12	23					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42875928	42875928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:42875928C>T	ENST00000025301.2	+	8	3221	c.3046C>T	c.(3046-3048)Cat>Tat	p.H1016Y		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1016					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTCTATGGTTCATGGATCCTC	0.423000													23	84					0	0	1	0	0
PURG	29942	broad.mit.edu	37	8	30889719	30889719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30889719G>A	ENST00000475541.1	-	1	1512	c.580C>T	c.(580-582)Cgc>Tgc	p.R194C	PURG_ENST00000339382.2_Missense_Mutation_p.R194C	NM_013357.2	NP_037489.1	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G	194						nucleus	DNA binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CGTAGGAAGCGACCCCGCTGA	0.488000													29	83					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62763577	62763577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62763577G>A	ENST00000336232.2	-	6	944	c.809C>T	c.(808-810)tCg>tTg	p.S270L	SLC22A8_ENST00000542795.1_5'UTR|SLC22A8_ENST00000535878.1_Missense_Mutation_p.S147L|SLC22A8_ENST00000545207.1_Missense_Mutation_p.S179L|SLC22A8_ENST00000430500.2_Missense_Mutation_p.S270L|SLC22A8_ENST00000311438.8_Missense_Mutation_p.S270L	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	270					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CAGGGCCTTCGAGGACTTTCC	0.577000													31	84					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009703	9009703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9009703G>A	ENST00000397910.4	-	39	39226	c.39023C>T	c.(39022-39024)cCt>cTt	p.P13008L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13010					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACCAGGAGAGGAACAGCTGC	0.453000													37	111					0	0	1	0	0
TTC38	55020	broad.mit.edu	37	22	46669961	46669961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46669961C>T	ENST00000381031.3	+	4	436	c.360C>T	c.(358-360)gcC>gcT	p.A120A	TTC38_ENST00000445282.2_Silent_p.A120A	NM_017931.2	NP_060401.2	Q5R3I4	TTC38_HUMAN	tetratricopeptide repeat domain 38	120							binding			endometrium(4)|large_intestine(3)|lung(4)|ovary(1)	12						AGACATTTGCCAATGGGTGAG	0.622000													18	37					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51993386	51993386	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51993386G>A	ENST00000220478.3	+	10	1555	c.1152G>A	c.(1150-1152)aaG>aaA	p.K384K	SCG3_ENST00000542355.2_Silent_p.K152K	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	384					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		GAAGCTTGAAGGATTCCACAA	0.423000													34	83					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208218435	208218435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:208218435G>A	ENST00000367033.3	-	19	4373	c.3616C>T	c.(3616-3618)Ctc>Ttc	p.L1206F		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1206	IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TGCCCGGTGAGGTTGGGAGGC	0.582000													23	59					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130778016	130778016	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:130778016G>A	ENST00000276708.4	-	4	1309	c.428C>T	c.(427-429)tCa>tTa	p.S143L		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	143						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CTTCAGAAATGATGGCTCTGG	0.502000													19	44					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30858825	30858825	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30858825C>T	ENST00000324771.8	+	7	1041	c.493C>T	c.(493-495)Cgc>Tgc	p.R165C	DDR1_ENST00000508312.1_Missense_Mutation_p.R183C|DDR1_ENST00000452441.1_Missense_Mutation_p.R165C|DDR1_ENST00000376575.3_Missense_Mutation_p.R165C|DDR1_ENST00000376569.3_Missense_Mutation_p.R165C|DDR1_ENST00000418800.2_Missense_Mutation_p.R165C|DDR1_ENST00000376570.4_Missense_Mutation_p.R165C|DDR1_ENST00000446312.1_Missense_Mutation_p.R165C|DDR1_ENST00000376568.3_Missense_Mutation_p.R165C|DDR1_ENST00000376567.2_Missense_Mutation_p.R165C|DDR1_ENST00000513240.1_Missense_Mutation_p.R165C|DDR1_ENST00000454612.2_Missense_Mutation_p.R165C|DDR1_ENST00000508472.1_3'UTR			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	165	F5/8 type C.			R -> H (in Ref. 14; AAH70070).	cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CCGACTGGTTCGCTTCTACCC	0.632000													17	59					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56663310	56663310	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56663310C>T	ENST00000389934.3	-	18	3039	c.2922G>A	c.(2920-2922)agG>agA	p.R974R	TEX14_ENST00000240361.8_Silent_p.R980R|TEX14_ENST00000349033.5_Silent_p.R974R	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	980						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTCTGGGCTCCTAATGGGGG	0.517000													58	121					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22133704	22133704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22133704G>A	ENST00000408935.1	+	1	408	c.408G>A	c.(406-408)atG>atA	p.M136I		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CCAATGTGATGAACATGAGAG	0.483000													69	126					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32705074	32705074	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:32705074T>A	ENST00000531481.1	-	7	713	c.437A>T	c.(436-438)aAa>aTa	p.K146I	CCDC73_ENST00000335185.5_Intron|CCDC73_ENST00000534415.1_Intron			Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	146										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					GTTTTGTAATTTCCTTACCAT	0.289000													12	33					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788508	42788508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42788508C>T	ENST00000372980.3	-	2	1791	c.919G>A	c.(919-921)Gaa>Aaa	p.E307K		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	307					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CTGGAGCGTTCGCTCACGCCG	0.677000													7	49					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742318	23742318	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23742318G>A	ENST00000255890.4	-	0	891																											CCCAGCACGGGACTGAAGCTG	0.677000													8	31					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65274970	65274970	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:65274970G>A	ENST00000381210.3	-	1	210	c.100C>T	c.(100-102)Cac>Tac	p.H34Y	TECRL_ENST00000507440.1_Missense_Mutation_p.H34Y	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	34					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						GACAAAAAGTGAAAATTTCTC	0.413000													29	71					0	0	1	0	0
UBA3	9039	broad.mit.edu	37	3	69111302	69111302	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:69111302G>A	ENST00000361055.4	-	10	776	c.722C>T	c.(721-723)tCt>tTt	p.S241F	UBA3_ENST00000540295.1_Missense_Mutation_p.S64F|UBA3_ENST00000415609.2_Missense_Mutation_p.S200F|UBA3_ENST00000349511.4_Missense_Mutation_p.S227F	NM_003968.3	NP_003959.3	Q8TBC4	UBA3_HUMAN	ubiquitin-like modifier activating enzyme 3	241					protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		CCTGGGCATAGATGCAATGGT	0.368000													53	119					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48414334	48414334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48414334C>T	ENST00000296438.5	+	2	263	c.77C>T	c.(76-78)tCc>tTc	p.S26F	FBXW12_ENST00000445170.1_Intron|FBXW12_ENST00000436231.1_Intron|FBXW12_ENST00000415155.1_Missense_Mutation_p.S26F	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	26	F-box.									breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGCAGGTTTCCCAGGTGAAC	0.542000													18	101					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965518	35965518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35965518C>T	ENST00000274278.3	-	4	1170	c.813G>A	c.(811-813)ttG>ttA	p.L271L	UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000507113.1_Silent_p.L237L|UGT3A1_ENST00000503189.1_Silent_p.L271L|UGT3A1_ENST00000333811.4_Silent_p.L217L	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	271						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTTTTTCCATCAAGCCTCCAA	0.448000													8	124					0	0	1	0	0
C12orf71	728858	broad.mit.edu	37	12	27235271	27235271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:27235271G>A	ENST00000429849.2	-	1	176	c.146C>T	c.(145-147)cCt>cTt	p.P49L		NM_001080406.1	NP_001073875.1	A8MTZ7	CL071_HUMAN	chromosome 12 open reading frame 71	49										endometrium(2)|large_intestine(1)|lung(4)|skin(1)	8						GTGGATGGAAGGACCCTTGGA	0.542000													8	34					0	0	1	0	0
ABCG5	64240	broad.mit.edu	37	2	44050043	44050043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:44050043C>T	ENST00000543989.1	-	6	1876	c.171G>A	c.(169-171)gaG>gaA	p.E57E	ABCG5_ENST00000260645.1_Silent_p.E452E|ABCG5_ENST00000405322.1_Silent_p.E281E			Q9H222	ABCG5_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 5	452	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CGTCCTGACTCTCCTGGTCGC	0.572000													11	24					0	0	1	0	0
PEX26	55670	broad.mit.edu	37	22	18562684	18562684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18562684C>T	ENST00000329627.6	+	3	481	c.275C>T	c.(274-276)gCc>gTc	p.A92V	PEX26_ENST00000428061.2_Missense_Mutation_p.A92V|PEX26_ENST00000399744.3_Missense_Mutation_p.A92V	NM_017929.5	NP_060399.1	Q7Z412	PEX26_HUMAN	peroxisomal biogenesis factor 26	92					protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			breast(1)|kidney(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						GGGATCCAGGCCCTGGCAGAA	0.522000													34	107					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11718523	11718523	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11718523G>A	ENST00000381486.2	+	6	1038	c.738G>A	c.(736-738)acG>acA	p.T246T	GREB1_ENST00000389825.3_Silent_p.T136T|GREB1_ENST00000234142.5_Silent_p.T246T|GREB1_ENST00000263834.5_Silent_p.T246T|GREB1_ENST00000381483.2_Silent_p.T246T	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	246						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TTCCTGGGACGAACCCCAGCA	0.617000													28	79					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113388681	113388681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113388681C>T	ENST00000228928.7	+	7	1737	c.1558C>T	c.(1558-1560)Cct>Tct	p.P520S	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	520	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						CCTTCAGTTTCCTGAGCAGAA	0.617000													18	52					0	0	1	0	0
IL5	3567	broad.mit.edu	37	5	131877530	131877530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131877530C>T	ENST00000231454.1	-	4	421	c.378G>A	c.(376-378)atG>atA	p.M126I		NM_000879.2	NP_000870.1	P05113	IL5_HUMAN	interleukin 5 (colony-stimulating factor, eosinophil)	126					immune response|inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of podosome assembly	extracellular space	cytokine activity|growth factor activity|interleukin-5 receptor binding			endometrium(1)|large_intestine(1)|stomach(1)|upper_aerodigestive_tract(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Pranlukast(DB01411)	ACTCGGTGTTCATTACACCAA	0.393000													20	76					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579376	44579376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44579376C>T	ENST00000289547.4	-	2	675	c.620G>A	c.(619-621)gGa>gAa	p.G207E	NPC1L1_ENST00000423141.1_Missense_Mutation_p.G207E|NPC1L1_ENST00000381160.3_Missense_Mutation_p.G207E|NPC1L1_ENST00000546276.1_Missense_Mutation_p.G207E	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	207					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GCCTGTGTCTCCCTGGAAGTT	0.632000													26	70					0	0	1	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111626048	111626048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111626048G>A	ENST00000527614.1	-	6	879	c.814C>T	c.(814-816)Cgc>Tgc	p.R272C	PPP2R1B_ENST00000427203.2_Missense_Mutation_p.R111C|PPP2R1B_ENST00000311129.5_Missense_Mutation_p.R272C|PPP2R1B_ENST00000393055.2_Missense_Mutation_p.R145C|PPP2R1B_ENST00000426998.2_Missense_Mutation_p.R208C|PPP2R1B_ENST00000341980.6_Missense_Mutation_p.R272C	NM_001177562.1|NM_002716.4	NP_001171033.1|NP_002707.3	P30154	2AAB_HUMAN	protein phosphatase 2, regulatory subunit A, beta	272							protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|liver(1)|lung(10)|prostate(1)|urinary_tract(2)	22		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		ACCATATAGCGAACGCGCCAA	0.408000													37	103					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72152307	72152307	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:72152307C>T	ENST00000555818.1	+	10	3681	c.3333C>T	c.(3331-3333)atC>atT	p.I1111I	SIPA1L1_ENST00000381232.3_Silent_p.I1111I|SIPA1L1_ENST00000537413.1_Silent_p.I586I|SIPA1L1_ENST00000358550.2_Silent_p.I1111I	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1111					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CCGCCAACATCCCTCGAAGCA	0.557000													18	47					0	0	1	0	0
EIF2AK2	5610	broad.mit.edu	37	2	37365703	37365703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37365703G>A	ENST00000233057.4	-	7	864	c.542C>T	c.(541-543)tCt>tTt	p.S181F	EIF2AK2_ENST00000395127.2_Missense_Mutation_p.S181F|EIF2AK2_ENST00000405334.1_Missense_Mutation_p.S181F	NM_001135651.2	NP_001129123.1	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 2	181					evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)	22		all_hematologic(82;0.248)				AGTAGCAAAAGAACCAGAGGA	0.368000													22	74					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17311449	17311449	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17311449C>T	ENST00000595618.1	+	26	4526	c.4372_splice	c.e26-1	p.A1458_splice	MYO9B_ENST00000594824.1_Splice_Site_p.A1458_splice|MYO9B_ENST00000397274.2_Splice_Site_p.A1458_splice	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1458	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						CCCCCTCAGCCCCCTCCGGAC	0.612000													8	15					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108178243	108178243	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108178243C>T	ENST00000273353.3	-	19	2102	c.2046G>A	c.(2044-2046)gtG>gtA	p.V682V	MYH15_ENST00000495753.2_5'UTR	NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	682	Actin-binding (By similarity).|Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TTATGCATCTCACAAAATGAG	0.303000													14	40					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468411	56468411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:56468411C>T	ENST00000288221.6	-	2	880	c.625G>A	c.(625-627)Gag>Aag	p.E209K		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	209						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CTCATCTGCTCCTTGAGGACA	0.458000													28	58					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131186709	131186709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:131186709G>A	ENST00000337057.3	-	17	2977	c.2796C>T	c.(2794-2796)tcC>tcT	p.S932S	EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000525193.1_Silent_p.S633S|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000531410.1_Silent_p.S53S|EPB41L2_ENST00000527659.1_Silent_p.S738S|EPB41L2_ENST00000528282.1_Silent_p.S674S|EPB41L2_ENST00000530481.1_Silent_p.S779S|EPB41L2_ENST00000445890.2_Silent_p.S674S|EPB41L2_ENST00000524581.1_Silent_p.S310S|EPB41L2_ENST00000527411.1_Silent_p.S862S|EPB41L2_ENST00000368128.2_Silent_p.S932S|EPB41L2_ENST00000529208.1_Silent_p.S862S	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	932	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTGTTGACACGGACTCAGATG	0.458000													20	48					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594268	179594268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179594268C>T	ENST00000589042.1	-	64	18839	c.18615G>A	c.(18613-18615)ctG>ctA	p.L6205L	TTN_ENST00000342992.6_Silent_p.L4961L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.L5888L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5888	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACAGGCTTCAGCTCTCTGA	0.463000													15	98					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28554407	28554407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28554407C>T	ENST00000452236.2	-	1	705	c.88G>A	c.(88-90)Gaa>Aaa	p.E30K	SCAND3_ENST00000530247.1_Intron	NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	30					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						GTGTGGTCTTCTTCTTTAACC	0.502000													30	57					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78969134	78969134	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78969134G>A	ENST00000545128.1	+	36	5710	c.5173_splice	c.e36+1	p.T1724_splice		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	789					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						AGGACACCACGGGTGAGGGAA	0.597000													4	5					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563857	176563857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176563857G>A	ENST00000367662.3	+	3	2281	c.1117G>A	c.(1117-1119)Gga>Aga	p.G373R	PAPPA2_ENST00000367661.3_Missense_Mutation_p.G373R	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	373					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CACTTACGATGGACGGCACAT	0.572000													15	57					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78458947	78458947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:78458947C>T	ENST00000566780.1	+	7	1152	c.786C>T	c.(784-786)tcC>tcT	p.S262S	WWOX_ENST00000408984.3_Silent_p.S262S|WWOX_ENST00000402655.2_Intron|WWOX_ENST00000406884.2_Intron|WWOX_ENST00000539474.2_Intron	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	262	Interaction with MAPT (By similarity).|Mediates targeting to the mitochondria (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		CCTCAGAGTCCCATCGGTGGG	0.463000													26	100					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43269343	43269343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43269343G>A	ENST00000372585.5	+	7	1069	c.974G>A	c.(973-975)gGg>gAg	p.G325E	SLC22A7_ENST00000372589.3_Missense_Mutation_p.G323E|SLC22A7_ENST00000372574.3_Missense_Mutation_p.G323E|SLC22A7_ENST00000487175.1_3'UTR	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	325						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GTGGCCGCCGGGGAACGGGTG	0.587000													19	36					0	0	1	0	0
TMEM71	137835	broad.mit.edu	37	8	133734298	133734298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133734298G>A	ENST00000356838.3	-	7	825	c.683C>T	c.(682-684)tCt>tTt	p.S228F	TMEM71_ENST00000377901.4_Missense_Mutation_p.S184F|TMEM71_ENST00000523829.1_Missense_Mutation_p.S247F	NM_144649.2	NP_653250.2	Q6P5X7	TMM71_HUMAN	transmembrane protein 71	247						integral to membrane		p.S228Y(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGCACATGCAGAAATGATTAA	0.348000													21	118					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30020409	30020409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30020409C>T	ENST00000350119.4	-	5	625	c.435G>A	c.(433-435)acG>acA	p.T145T	DOC2A_ENST00000564979.1_Silent_p.T145T|DOC2A_ENST00000564944.1_Silent_p.T145T	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	145	C2 1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						TCTGAGTCTTCGTTTTTAGCT	0.572000													9	44					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39382856	39382856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39382856G>A	ENST00000545653.1	-	9	1672	c.1142C>T	c.(1141-1143)cCt>cTt	p.P381L	DAB2_ENST00000509337.1_Missense_Mutation_p.P381L|DAB2_ENST00000320816.6_Missense_Mutation_p.P402L|DAB2_ENST00000339788.6_Intron	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	402					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			TCCTTTGGGAGGGCTTCCCAC	0.507000													30	89					0	0	1	0	0
PPP4C	5531	broad.mit.edu	37	16	30094997	30094997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30094997C>T	ENST00000279387.7	+	7	667	c.499C>T	c.(499-501)Ctc>Ttc	p.L167F	PPP4C_ENST00000561610.1_Missense_Mutation_p.L167F	NM_002720.1	NP_002711.1	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	167					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(2)|pancreas(1)|skin(1)|urinary_tract(1)	9						GCACGGGGGCCTCTCCCCCTC	0.632000													24	53					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22941460	22941460	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22941460T>C	ENST00000397104.3	-	5	977	c.978A>G	c.(976-978)gtA>gtG	p.V326V	ZNF99_ENST00000596209.1_Silent_p.V417V					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CAGTATGAATTACCTTATGTA	0.358000													19	63					0	0	1	0	0
BATF	10538	broad.mit.edu	37	14	76013010	76013010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:76013010C>T	ENST00000286639.6	+	3	632	c.374C>T	c.(373-375)cCc>cTc	p.P125L	BATF_ENST00000555504.1_Intron|BATF_ENST00000555795.1_3'UTR	NM_006399.3	NP_006390.1	Q16520	BATF_HUMAN	basic leucine zipper transcription factor, ATF-like	125						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.028)		CGCTTCCAGCCCTGAGCTTCC	0.697000													5	13					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70087514	70087514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70087514G>A	ENST00000330891.5	-	4	647	c.421C>T	c.(421-423)Cgc>Tgc	p.R141C	BEST3_ENST00000476098.1_5'UTR|BEST3_ENST00000393365.1_Missense_Mutation_p.R35C|BEST3_ENST00000553096.1_Missense_Mutation_p.R35C|BEST3_ENST00000551160.1_Missense_Mutation_p.R35C|BEST3_ENST00000533674.1_5'UTR|BEST3_ENST00000331471.4_Missense_Mutation_p.R141C|BEST3_ENST00000266661.4_Missense_Mutation_p.R35C	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	141						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CTCACCGAGCGAAAGATGAGC	0.532000													31	68					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808114	48808114	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48808114C>T	ENST00000309835.3	+	1	352	c.342C>T	c.(340-342)ctC>ctT	p.L114L	STON1_ENST00000404752.1_Silent_p.L114L|STON1-GTF2A1L_ENST00000402114.2_Silent_p.L114L|STON1-GTF2A1L_ENST00000394751.3_Silent_p.L114L|STON1-GTF2A1L_ENST00000394754.1_Silent_p.L114L|STON1-GTF2A1L_ENST00000309827.2_Silent_p.L114L|STON1_ENST00000406226.1_Silent_p.L114L|STON1-GTF2A1L_ENST00000405008.1_Silent_p.L114L					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACAGCCCACTCGCAATATCAG	0.473000													39	68					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60737753	60737753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:60737753G>A	ENST00000400324.4	-	1	368	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S	DIAPH3_ENST00000400319.1_Missense_Mutation_p.P50S|DIAPH3_ENST00000400320.1_Missense_Mutation_p.P50S|DIAPH3_ENST00000400330.1_Missense_Mutation_p.P50S|DIAPH3_ENST00000377908.2_Missense_Mutation_p.P50S|DIAPH3_ENST00000267215.4_Missense_Mutation_p.P50S	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	50					actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GGCTCCTCGGGGCCACTGGGC	0.711000													18	52					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149494363	149494363	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149494363C>T	ENST00000378016.2	+	0	6834							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCCCCAGATTCCATTCCACAG	0.652000													13	67					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26241088	26241088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26241088C>T	ENST00000265944.5	+	3	215	c.49C>T	c.(49-51)Cct>Tct	p.P17S	MYO3A_ENST00000376301.1_Missense_Mutation_p.P17S|MYO3A_ENST00000543632.1_Missense_Mutation_p.P17S|MYO3A_ENST00000376302.1_Missense_Mutation_p.P17S	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	17					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CTTTCCTGATCCTTCTGATAC	0.333000													26	75					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	32483179	32483179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:32483179C>T	ENST00000359872.6	-	1	1134	c.373G>A	c.(373-375)Gac>Aac	p.D125N		NM_001094.4	NP_001085.2	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	125					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	AGATGGGGGTCCGGGATCTGC	0.597000													28	45					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754616	49754616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49754616G>A	ENST00000304801.3	-	1	437	c.285C>T	c.(283-285)ttC>ttT	p.F95F		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	95					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					AGTCCTTCAGGAACAGAACAT	0.527000													42	106					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14022123	14022123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:14022123C>T	ENST00000382080.1	-	5	1228	c.513G>A	c.(511-513)gaG>gaA	p.E171E	RP11-3G21.1_ENST00000527110.1_RNA|SGCZ_ENST00000421524.2_Silent_p.E124E	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	158					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CAATGGTAATCTCATCTTCAT	0.423000													12	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179441006	179441006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179441006C>T	ENST00000589042.1	-	326	70077	c.69853G>A	c.(69853-69855)Gag>Aag	p.E23285K	TTN_ENST00000342992.6_Missense_Mutation_p.E20717K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E14220K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E14412K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E14345K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E21644K|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21644	Fibronectin type-III 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCCAGGCCTCGTCTCCTACT	0.443000													25	42					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160849133	160849133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160849133C>T	ENST00000326245.3	-	7	872	c.757G>A	c.(757-759)Gga>Aga	p.G253R	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	253	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACCCTCATTCCAGCACACAAG	0.502000													35	85					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012875	29012875	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29012875G>A	ENST00000377175.1	-	1	142	c.78C>T	c.(76-78)atC>atT	p.I26I		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						CTCCTGACAGGATCATCTCCA	0.403000													44	110					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46832585	46832585	+	Missense_Mutation	SNP	G	G	A	rs145401391		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46832585G>A	ENST00000339613.2	+	12	1649	c.1394G>A	c.(1393-1395)cGg>cAg	p.R465Q	HIF3A_ENST00000244303.6_Missense_Mutation_p.R452Q|HIF3A_ENST00000420102.2_Missense_Mutation_p.R470Q|AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000600383.1_Missense_Mutation_p.R452Q|HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000300862.3_Missense_Mutation_p.R519Q|HIF3A_ENST00000377670.4_Missense_Mutation_p.R521Q			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	521	NTAD.|ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GCTGTCCCCCGGCCCCGTGCT	0.672000													25	62					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108117950	108117950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108117950G>A	ENST00000273353.3	-	35	5017	c.4961C>T	c.(4960-4962)tCc>tTc	p.S1654F		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1654						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTGGCCCAGGGATTTGGTTGC	0.468000													25	61					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1775232	1775232	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1775232G>A	ENST00000236671.2	-	7	1096	c.964C>T	c.(964-966)Cag>Tag	p.Q322*	RP11-295K3.1_ENST00000427721.1_Silent_p.F192F	NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	322					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCTCGCCCTGAATCAGCGGC	0.692000													9	10					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169589405	169589405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169589405G>A	ENST00000261509.6	+	3	1184	c.973G>A	c.(973-975)Gac>Aac	p.D325N	PALLD_ENST00000512127.1_5'UTR|PALLD_ENST00000333488.4_Missense_Mutation_p.D202N|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Missense_Mutation_p.D325N	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	325	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TGAGGGAGGGGACCTCCATAC	0.517000									Pancreatic Cancer, Familial Clustering of				33	99					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58275715	58275715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58275715G>A	ENST00000300896.4	-	27	3534	c.3340C>T	c.(3340-3342)Cgg>Tgg	p.R1114W	USP32_ENST00000592339.1_Missense_Mutation_p.R784W	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	1114					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TCTTTCTTCCGGGTATGCACA	0.478000													50	122					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228509413	228509413	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228509413G>A	ENST00000570156.2	+	66	17816	c.17742G>A	c.(17740-17742)ctG>ctA	p.L5914L	OBSCN_ENST00000366707.4_Silent_p.L2591L|OBSCN_ENST00000422127.1_Silent_p.L4957L|OBSCN_ENST00000284548.11_Silent_p.L4957L|OBSCN_ENST00000366709.4_Silent_p.L2076L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4957	PH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCTCTCTGCTGATCACTGGCC	0.612000													22	53					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196799399	196799399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196799399C>T	ENST00000312428.6	-	21	3487	c.3387G>A	c.(3385-3387)gaG>gaA	p.E1129E		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1129	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTGAAATAATCTCTATGAGTT	0.393000													68	159					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2418758	2418758	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2418758C>T	ENST00000449969.1	+	7	1137	c.976C>T	c.(976-978)Cag>Tag	p.Q326*	PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000288766.5_Intron|PLCH2_ENST00000419816.2_Nonsense_Mutation_p.Q353*|PLCH2_ENST00000378486.3_Nonsense_Mutation_p.Q353*|PLCH2_ENST00000378488.3_Nonsense_Mutation_p.Q353*			O75038	PLCH2_HUMAN	phospholipase C, eta 2	353	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GCTCATGTCCCAGTCACGGGT	0.627000													7	25					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148921668	148921668	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148921668C>T	ENST00000262085.3	+	8	2050	c.1945C>T	c.(1945-1947)Ctg>Ttg	p.L649L	ZNF282_ENST00000479907.1_3'UTR	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	649					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CAAGGACCACCTGCGCGTGCA	0.731000													9	31					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7675993	7675993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7675993C>T	ENST00000446248.2	+	11	1244	c.1143C>T	c.(1141-1143)ttC>ttT	p.F381F	CAMSAP3_ENST00000160298.4_Silent_p.F354F	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	354					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CTCCTGTCTTCACCTTCCGCC	0.652000													41	81					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	73043362	73043362	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73043362A>G	ENST00000264839.7	+	25	3737	c.3737A>G	c.(3736-3738)aAg>aGg	p.K1246R	RIMS1_ENST00000348717.5_Missense_Mutation_p.K1180R|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000538414.1_Missense_Mutation_p.K203R|RIMS1_ENST00000517960.1_Missense_Mutation_p.K1180R|RIMS1_ENST00000491071.2_Missense_Mutation_p.K1220R|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000401910.3_Missense_Mutation_p.K717R|RIMS1_ENST00000425662.2_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000521978.1_Missense_Mutation_p.K1397R|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000518273.1_Intron			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1397					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TCCATCATGAAGAGCACCAGT	0.448000													3	9					0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23647609	23647609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23647609G>A	ENST00000261584.4	-	4	410	c.258C>T	c.(256-258)acC>acT	p.T86T		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	86	Interaction with BRCA1.|Interaction with RAD51.|Required for its oligomerization and is important for its focal concentration at DNA damage sites.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		CATCAAGATGGGTTTTGATGT	0.328000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					9	16					0	0	1	0	0
MSRB3	253827	broad.mit.edu	37	12	65857063	65857063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:65857063G>A	ENST00000308259.5	+	7	793	c.519G>A	c.(517-519)ggG>ggA	p.G173G	MSRB3_ENST00000535664.1_Silent_p.G173G|MSRB3_ENST00000355192.3_Silent_p.G180G	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	180					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		GAGGCAGTGGGGTCGCCAGCC	0.502000													14	44					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55522891	55522891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:55522891G>A	ENST00000436346.1	-	31	6234	c.5393C>T	c.(5392-5394)cCt>cTt	p.P1798L	CCDC88A_ENST00000413716.2_Intron|CCDC88A_ENST00000336838.6_Missense_Mutation_p.P1797L|CCDC88A_ENST00000263630.8_Missense_Mutation_p.P1770L|CCDC88A_ENST00000422883.2_Missense_Mutation_p.P299L	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1798					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						AGTTGCATAAGGGTTACTATC	0.413000													31	79					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64746713	64746713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:64746713G>A	ENST00000543942.2	-	2	1002	c.376C>T	c.(376-378)Cta>Tta	p.L126L	C12orf56_ENST00000333722.5_Silent_p.L126L|RPS11P6_ENST00000535684.1_RNA	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	126										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		AATGGAAATAGGAATTTCCTG	0.333000													5	49					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12164447	12164447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12164447G>A	ENST00000263932.2	+	4	502	c.280G>A	c.(280-282)Gag>Aag	p.E94K	TNFRSF8_ENST00000417814.2_5'UTR	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	94					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		CGACCTCGTGGAGAAGACGCC	0.592000													28	70					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41166002	41166002	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41166002C>T	ENST00000483722.1	-	2	406	c.221G>A	c.(220-222)gGg>gAg	p.G74E		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	74	Ig-like V-type.				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					GTAGCGGGGCCCTTTCACCCA	0.577000													48	128					0	0	1	0	0
DGUOK	1716	broad.mit.edu	37	2	74185845	74185845	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74185845C>T	ENST00000264093.4	+	7	901	c.816C>T	c.(814-816)acC>acT	p.T272T	DGUOK-AS1_ENST00000453103.1_RNA|DGUOK-AS1_ENST00000413452.1_RNA|DGUOK_ENST00000348222.1_Silent_p.T184T|DGUOK_ENST00000462685.1_3'UTR|DGUOK_ENST00000356837.6_Silent_p.T250T|DGUOK-AS1_ENST00000439192.1_RNA	NM_080916.2	NP_550438.1	Q16854	DGUOK_HUMAN	deoxyguanosine kinase	272					guanosine metabolic process|purine base metabolic process|purine deoxyribonucleoside metabolic process|purine-containing compound salvage	mitochondrial matrix	ATP binding|deoxyguanosine kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(1)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	8						AGGTAAACACCTTTGTAAAGA	0.413000													18	68					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114058095	114058095	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:114058095G>A	ENST00000462705.1	-	12	2585	c.1764C>T	c.(1762-1764)tcC>tcT	p.S588S	ZBTB20_ENST00000474710.1_Silent_p.S661S|ZBTB20_ENST00000357258.3_Silent_p.S588S|ZBTB20_ENST00000471418.1_Silent_p.S588S|ZBTB20_ENST00000481632.1_Silent_p.S588S|ZBTB20_ENST00000464560.1_Silent_p.S588S|ZBTB20_ENST00000393785.2_Silent_p.S588S	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	661					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		AGCACTCGTAGGACTTCTCTC	0.577000													19	201					0	0	1	0	0
SGCD	6444	broad.mit.edu	37	5	155771593	155771593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:155771593G>A	ENST00000435422.3	+	2	582	c.95G>A	c.(94-96)cGa>cAa	p.R32Q	SGCD_ENST00000337851.4_Missense_Mutation_p.R33Q|SGCD_ENST00000447401.1_Missense_Mutation_p.R33Q|SGCD_ENST00000517913.1_Missense_Mutation_p.R33Q	NM_001128209.1	NP_001121681.1	Q92629	SGCD_HUMAN	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	32					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|prostate(1)	24	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGCGGAAACGATGCCTGTAT	0.483000													9	81					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76382154	76382154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76382154C>T	ENST00000357063.3	+	11	3151	c.1891C>T	c.(1891-1893)Cct>Tct	p.P631S	LMO7_ENST00000341547.4_Intron|LMO7_ENST00000377534.3_Missense_Mutation_p.P631S|LMO7_ENST00000321797.8_Missense_Mutation_p.P346S|LMO7_ENST00000465261.2_Missense_Mutation_p.P346S|LMO7_ENST00000526202.1_Intron			Q8WWI1	LMO7_HUMAN	LIM domain 7	631						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AATATTAGTTCCTTCATATCG	0.448000													7	65					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63726506	63726506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:63726506C>T	ENST00000421025.1	+	5	764	c.495C>T	c.(493-495)ttC>ttT	p.F165F	ZNF679_ENST00000255746.4_Silent_p.F165F	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						TCAAAGTCTTCGGCAAATTTT	0.328000													8	22					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233515108	233515108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233515108G>A	ENST00000366624.3	+	9	2617	c.2356G>A	c.(2356-2358)Gag>Aag	p.E786K	MLK4_ENST00000366622.1_Missense_Mutation_p.E232K	NM_032435.2	NP_115811.2																					CACCTGTGGGGAGGCCAGCAG	0.597000													8	79					0	0	1	0	0
C2orf62	375307	broad.mit.edu	37	2	219232205	219232205	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219232205G>A	ENST00000289388.3	+	9	914	c.885G>A	c.(883-885)gaG>gaA	p.E295E	C2orf62_ENST00000481940.1_3'UTR|AC021016.6_ENST00000441749.1_RNA	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	295										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TATGGGAGGAGGATATGGAGC	0.567000													39	93					0	0	1	0	0
INHBE	83729	broad.mit.edu	37	12	57849343	57849343	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57849343C>T	ENST00000266646.2	+	1	240	c.24C>T	c.(22-24)ctC>ctT	p.L8L	INHBE_ENST00000551553.1_Intron	NM_031479.3	NP_113667.1	P58166	INHBE_HUMAN	inhibin, beta E	8					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						ATGTCCAGCTCTGGCTGGTGC	0.632000													7	37					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57762304	57762304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57762304G>A	ENST00000360716.3	+	17	2420	c.2199G>A	c.(2197-2199)gaG>gaA	p.E733E	CCDC135_ENST00000394337.4_Silent_p.E733E|CCDC135_ENST00000336825.8_Silent_p.E668E			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	733						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						CTTTACAGGAGCGCATGATGC	0.587000													54	124					0	0	1	0	0
SLC25A19	60386	broad.mit.edu	37	17	73282450	73282450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73282450G>A	ENST00000402418.3	-	2	1132	c.223C>T	c.(223-225)Ccg>Tcg	p.P75S	SLC25A19_ENST00000320362.3_Missense_Mutation_p.P75S|SLC25A19_ENST00000580994.1_Missense_Mutation_p.P75S|SLC25A19_ENST00000442286.2_Missense_Mutation_p.P75S|SLC25A19_ENST00000416858.2_Missense_Mutation_p.P75S|SLC25A19_ENST00000375261.4_Missense_Mutation_p.P75S			Q9HC21	TPC_HUMAN	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	75						integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			AAAGCTGTCGGACCCTCCTCC	0.577000													35	99					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102711298	102711298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102711298G>A	ENST00000299855.5	-	5	908	c.652C>T	c.(652-654)Cat>Tat	p.H218Y		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	218					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CCAATTTCATGAGCAGCAACG	0.423000													33	80					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754498	49754498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49754498G>A	ENST00000304801.3	-	1	555	c.403C>T	c.(403-405)Ccc>Tcc	p.P135S		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	135					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TTTCCAGAGGGATCTTGGCCC	0.507000													7	109					0	0	1	0	0
H2BFM	286436	broad.mit.edu	37	X	103294923	103294923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:103294923G>A	ENST00000243297.5	+	3	689	c.689G>A	c.(688-690)gGg>gAg	p.G230E	H2BFM_ENST00000355016.3_Missense_Mutation_p.G127E					H2B histone family, member M											endometrium(1)|lung(1)|ovary(1)	3						CTGCTGCCGGGGAAGATGGGC	0.647000													3	3					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17138385	17138385	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:17138385G>A	ENST00000285681.2	+	3	562	c.193G>A	c.(193-195)Gag>Aag	p.E65K	USP25_ENST00000400183.2_Missense_Mutation_p.E65K|USP25_ENST00000351097.5_Missense_Mutation_p.E65K|USP25_ENST00000285679.6_Missense_Mutation_p.E65K			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	65					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		CCCTCAGCAGGAGGAGACAAC	0.398000													7	92					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62407280	62407280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62407280C>T	ENST00000245663.4	-	3	1123	c.973G>A	c.(973-975)Gac>Aac	p.D325N	ZBTB46_ENST00000302995.2_Missense_Mutation_p.D325N|ZBTB46_ENST00000395104.1_Missense_Mutation_p.D325N	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CCTCGGCTGTCGGAGCTGCTG	0.637000													29	54					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88854251	88854251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88854251G>A	ENST00000537554.1	-	2	4305	c.743C>T	c.(742-744)gCc>gTc	p.A248V	CNR1_ENST00000549890.1_Missense_Mutation_p.A248V|CNR1_ENST00000468898.1_Missense_Mutation_p.A215V|CNR1_ENST00000535130.1_Missense_Mutation_p.A248V|CNR1_ENST00000549716.1_Missense_Mutation_p.A187V|CNR1_ENST00000369501.2_Missense_Mutation_p.A248V|CNR1_ENST00000428600.2_Missense_Mutation_p.A248V|CNR1_ENST00000369499.2_Missense_Mutation_p.A248V|CNR1_ENST00000362094.5_3'UTR	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	248					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	AGGCAGCACGGCGATCACAAT	0.527000													9	65					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128463994	128463994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128463994C>T	ENST00000322313.4	-	22	4072	c.3914G>A	c.(3913-3915)cGa>cAa	p.R1305Q		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1305					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CCGGCCCCCTCGAGAAGGGGT	0.617000													32	204					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9402046	9402046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9402046C>T	ENST00000378501.2	+	23	2236	c.2221C>T	c.(2221-2223)Cgc>Tgc	p.R741C	PLCB4_ENST00000414679.2_Missense_Mutation_p.R753C|PLCB4_ENST00000378493.1_Missense_Mutation_p.R741C|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.R741C|PLCB4_ENST00000378473.3_Missense_Mutation_p.R753C|PLCB4_ENST00000334005.3_Missense_Mutation_p.R741C	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	741	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						ATTCCGAACTCGCATGGTTAT	0.388000													28	72					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23731413	23731413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23731413G>A	ENST00000304749.2	-	1	161	c.91C>T	c.(91-93)Ccg>Tcg	p.P31S	CST1_ENST00000398402.1_Missense_Mutation_p.P31S	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	31			P -> L (in dbSNP:rs2070856).			extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					ATGCCACCCGGGATTATCCTA	0.562000													5	51					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150696415	150696415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150696415G>A	ENST00000297494.3	+	9	1451	c.1094G>A	c.(1093-1095)aGg>aAg	p.R365K	NOS3_ENST00000461406.1_Missense_Mutation_p.R159K|NOS3_ENST00000467517.1_Missense_Mutation_p.R365K|NOS3_ENST00000484524.1_Missense_Mutation_p.R365K	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	365	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	ATCGGCACGAGGAACCTGTGT	0.627000													41	158					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52826857	52826857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52826857C>T	ENST00000252245.5	-	2	898	c.678G>A	c.(676-678)agG>agA	p.R226R		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	226	Coil 1B.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		CCTGCATGTTCCTCAGTTCAG	0.537000													34	77					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67223077	67223077	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67223077T>C	ENST00000314586.6	-	3	293	c.53A>G	c.(52-54)gAg>gGg	p.E18G	EXOC3L1_ENST00000562887.1_5'UTR	NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	18	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						CTCTGGCCACTCAGGTCCTGG	0.597000													8	8					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89658656	89658656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89658656C>T	ENST00000355754.6	-	5	698	c.601G>A	c.(601-603)Gag>Aag	p.E201K		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	201						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		AACTTTAGCTCCAGGGTAAAA	0.493000													32	94					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125591686	125591686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125591686C>T	ENST00000316519.6	+	8	993	c.787C>T	c.(787-789)Ctt>Ttt	p.L263F	AACS_ENST00000316543.10_5'UTR|AACS_ENST00000261686.6_Missense_Mutation_p.L263F	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	263					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		GGATGACTTTCTTGCCACCGG	0.607000													25	60					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69000035	69000035	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:69000035G>T	ENST00000288368.4	+	19	2381	c.2104G>T	c.(2104-2106)Gta>Tta	p.V702L	PREX2_ENST00000529398.1_3'UTR|RP11-403D15.2_ENST00000526901.1_RNA	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	702	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TGTGCATGCTGTAGGAAGAGG	0.453000													37	142					1.47244e-24	1.48221e-24	1	1	0
NAALADL2	254827	broad.mit.edu	37	3	175041968	175041968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:175041968C>T	ENST00000454872.1	+	5	1072	c.944C>T	c.(943-945)tCc>tTc	p.S315F	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	315					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TTTTAGCTTTCCTCATTGGAA	0.378000													43	262					0	0	1	0	0
S100A12	6283	broad.mit.edu	37	1	153347053	153347053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153347053C>T	ENST00000368737.3	-	2	133	c.16G>A	c.(16-18)Gag>Aag	p.E6K		NM_005621.1	NP_005612.1	P80511	S10AC_HUMAN	S100 calcium binding protein A12	6					defense response to bacterium|defense response to fungus|inflammatory response|innate immune response|killing of cells of other organism|positive regulation of I-kappaB kinase/NF-kappaB cascade|xenobiotic metabolic process	cytosol|extracellular region|insoluble fraction|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			endometrium(1)|kidney(1)|skin(2)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	TCCAGATGCTCTTCAAGTTTT	0.483000													48	110					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75857507	75857507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:75857507C>T	ENST00000322507.8	-	23	4610	c.4301G>A	c.(4300-4302)cGa>cAa	p.R1434Q	COL12A1_ENST00000345356.6_Missense_Mutation_p.R270Q|COL12A1_ENST00000483888.2_Missense_Mutation_p.R1434Q|COL12A1_ENST00000416123.2_Missense_Mutation_p.R1434Q	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1434	Fibronectin type-III 9.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AGTTTCCATTCGACTCACATA	0.368000													19	132					0	0	1	0	0
CLSPN	63967	broad.mit.edu	37	1	36226473	36226473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36226473G>A	ENST00000251195.5	-	8	1145	c.1049C>T	c.(1048-1050)aCt>aTt	p.T350I	CLSPN_ENST00000520551.1_Missense_Mutation_p.T350I|CLSPN_ENST00000373220.3_Missense_Mutation_p.T350I|CLSPN_ENST00000318121.3_Missense_Mutation_p.T350I			Q9HAW4	CLSPN_HUMAN	claspin	350					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGTATTTGCAGTGTCTATGAT	0.373000													18	63					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	53986319	53986319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53986319C>T	ENST00000312233.2	-	6	1755	c.1189G>A	c.(1189-1191)Gag>Aag	p.E397K		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	397					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GGGAGCAGCTCCTGGCCCAGG	0.677000													6	21					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24563606	24563606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24563606G>A	ENST00000535378.1	-	17	3187	c.2545C>T	c.(2545-2547)Cgg>Tgg	p.R849W	KIAA0319_ENST00000378214.3_Missense_Mutation_p.R858W|KIAA0319_ENST00000430948.2_Missense_Mutation_p.R813W|KIAA0319_ENST00000543707.1_Missense_Mutation_p.R858W|KIAA0319_ENST00000537886.1_Missense_Mutation_p.R858W	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	858					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GAGTGGGCCCGAATCTTCTGG	0.567000													18	39					0	0	1	0	0
FSCN3	29999	broad.mit.edu	37	7	127239494	127239494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127239494C>T	ENST00000265825.5	+	5	1399	c.1180C>T	c.(1180-1182)Cgt>Tgt	p.R394C	FSCN3_ENST00000420086.2_Missense_Mutation_p.R260C	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	394						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						ATTGCGAGGTCGTTATGGCTA	0.507000													43	72					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128677123	128677123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128677123G>A	ENST00000344954.6	+	7	1059	c.671G>A	c.(670-672)cGg>cAg	p.R224Q	FLI1_ENST00000429175.2_Missense_Mutation_p.R257Q|FLI1_ENST00000534087.1_Missense_Mutation_p.R224Q|FLI1_ENST00000281428.8_Missense_Mutation_p.R191Q|FLI1_ENST00000525560.1_Missense_Mutation_p.R64Q			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	257					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		ACAGAGCAACGGCCCCAGCCA	0.512000			T	EWSR1	Ewing sarcoma								7	19					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136596793	136596793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136596793G>A	ENST00000531224.1	-	6	1981	c.1729C>T	c.(1729-1731)Cat>Tat	p.H577Y	BCLAF1_ENST00000392348.2_Missense_Mutation_p.H575Y|BCLAF1_ENST00000530767.1_Missense_Mutation_p.H404Y|BCLAF1_ENST00000527759.1_Missense_Mutation_p.H575Y|BCLAF1_ENST00000527536.1_Missense_Mutation_p.H577Y|BCLAF1_ENST00000353331.4_Missense_Mutation_p.H575Y	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	577					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTGACAGAATGGACAAGTGTA	0.398000													17	189					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657830	72657830	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72657830G>A	ENST00000425256.1	-	0	2081					NR_002164.1																						gacgatttgggagtgtccttg	0.507000													70	189					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65016033	65016033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:65016033C>T	ENST00000394156.3	-	8	1624	c.1171G>A	c.(1171-1173)Gaa>Aaa	p.E391K	CDH11_ENST00000268603.4_Missense_Mutation_p.E391K|CDH11_ENST00000566827.1_Missense_Mutation_p.E265K			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	391	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TCTTGGACTTCGTGGATGTAA	0.502000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			17	105					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11725817	11725817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11725817C>T	ENST00000262442.3	+	47	8981	c.8913C>T	c.(8911-8913)gcC>gcT	p.A2971A	DNAH9_ENST00000454412.2_Silent_p.A2971A	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2971	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGTTCCCAGCCATTGTGAACT	0.552000													48	67					0	0	1	0	0
ADGRG6	57211	broad.mit.edu	37	6	142691444	142691444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:142691444G>A	ENST00000230173.6	+	4	1059	c.583G>A	c.(583-585)Gaa>Aaa	p.E195K	GPR126_ENST00000545477.1_Intron|GPR126_ENST00000296932.8_Missense_Mutation_p.E195K|GPR126_ENST00000367608.2_Missense_Mutation_p.E195K|GPR126_ENST00000367609.3_Missense_Mutation_p.E195K	NM_020455.5	NP_065188.4	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	195	Pentaxin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		AGTTGGCCATGAAGACAGTGA	0.438000													14	24					0	0	1	0	0
CSRP3	8048	broad.mit.edu	37	11	19207763	19207763	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:19207763C>T	ENST00000533783.1	-	5	654	c.414_splice	c.e5+1	p.K138_splice	CSRP3_ENST00000265968.3_Splice_Site_p.K138_splice	NM_003476.4	NP_003467.1	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3 (cardiac LIM protein)	138	LIM zinc-binding 2.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10						AAGGTCTTACCTTGCCACCTC	0.498000													21	83					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063593	9063593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9063593C>T	ENST00000397910.4	-	3	24056	c.23853G>A	c.(23851-23853)agG>agA	p.R7951R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7953	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGGACCCCTCCTCATAAGAG	0.463000													7	63					0	0	1	0	0
FBXL16	146330	broad.mit.edu	37	16	747111	747111	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:747111C>T	ENST00000397621.1	-	2	626	c.295G>A	c.(295-297)Gag>Aag	p.E99K	FBXL16_ENST00000324361.5_Missense_Mutation_p.E99K	NM_153350.3	NP_699181.2	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	99	F-box.									endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)	10		Hepatocellular(780;0.0218)				AGGATCTTCTCGTCCGTGGCC	0.697000													7	39					0	0	1	0	0
OR52N5	390075	broad.mit.edu	37	11	5799018	5799018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5799018G>A	ENST00000317093.2	-	1	879	c.847C>T	c.(847-849)Cac>Tac	p.H283Y	TRIM5_ENST00000380027.1_Intron	NM_001001922.2	NP_001001922.2	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N, member 5	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(1)|lung(17)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ACAATGATGTGAAGAGAAGGG	0.423000													24	14					0	0	1	0	0
PUS7	54517	broad.mit.edu	37	7	105105785	105105785	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:105105785G>A	ENST00000356362.2	-	13	1816	c.1602C>T	c.(1600-1602)ttC>ttT	p.F534F	PUS7_ENST00000469408.1_Silent_p.F534F	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	534	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding	p.F534F(2)		breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						AGATAACATCGAAACCAGGCA	0.343000													17	46					0	0	1	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474748	20474748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20474748C>T	ENST00000375102.3	+	5	592	c.490C>T	c.(490-492)Ctc>Ttc	p.L164F		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	121					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GGTTCTGTGCCTCATGAACCA	0.557000													14	116					0	0	1	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90673158	90673158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90673158C>T	ENST00000371927.3	+	6	1679	c.721C>T	c.(721-723)Cac>Tac	p.H241Y	STAMBPL1_ENST00000371926.3_Missense_Mutation_p.H241Y|STAMBPL1_ENST00000371922.1_Missense_Mutation_p.H75Y|STAMBPL1_ENST00000371924.1_Missense_Mutation_p.H241Y			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	241							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TTATGCTAGCCACTCTCCTCC	0.463000													46	89					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50895042	50895042	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50895042G>A	ENST00000380817.2	-	30	4148	c.3965C>T	c.(3964-3966)tCc>tTc	p.S1322F	SBF1_ENST00000348911.6_Missense_Mutation_p.S1297F|SBF1_ENST00000390679.3_Missense_Mutation_p.S1296F|SBF1_ENST00000476293.1_5'UTR	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	1296	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		AGCTAGCCGGGAGCCCACATC	0.677000													6	16					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175048543	175048543	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175048543G>A	ENST00000239462.4	+	3	597	c.484G>A	c.(484-486)Gag>Aag	p.E162K		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	162					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGAGGGCAGGGAGGGCCCCGC	0.711000													15	7					0	0	1	0	0
FAM73A	374986	broad.mit.edu	37	1	78269072	78269072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:78269072C>T	ENST00000370791.3	+	4	523	c.491C>T	c.(490-492)tCt>tTt	p.S164F	FAM73A_ENST00000443751.2_Missense_Mutation_p.S126F	NM_001270384.1|NM_198549.3	NP_001257313.1|NP_940951.1	Q8NAN2	FA73A_HUMAN	family with sequence similarity 73, member A	164						integral to membrane				breast(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	19				Colorectal(170;0.226)		TATTCAGGTTCTGCACAGAGT	0.299000													16	48					0	0	1	0	0
DRG1	4733	broad.mit.edu	37	22	31807018	31807018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31807018C>T	ENST00000331457.4	+	4	524	c.363C>T	c.(361-363)atC>atT	p.I121I	DRG1_ENST00000433341.1_3'UTR	NM_004147.3	NP_004138.1	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	121	G.				multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|urinary_tract(1)	11						TCCCAGGTATCATTGAAGGTG	0.413000													23	58					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103120032	103120032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103120032C>T	ENST00000295269.4	+	3	1303	c.846C>T	c.(844-846)atC>atT	p.I282I		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	282					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TGTTTGGCATCGTTTTTGGAT	0.398000													21	51					0	0	1	0	0
LPPR3	79948	broad.mit.edu	37	19	815761	815761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:815761C>T	ENST00000359894.2	-	3	229	c.166G>A	c.(166-168)Gac>Aac	p.D56N	LPPR3_ENST00000520876.3_Missense_Mutation_p.D56N	NM_024888.2	NP_079164.1	Q6T4P5	LPPR3_HUMAN		56						integral to membrane	phosphatidate phosphatase activity										AGAGTGCGGTCATAGCACTGG	0.617000													7	31					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73731423	73731423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:73731423G>A	ENST00000427855.1	+	22	3216	c.3114G>A	c.(3112-3114)caG>caA	p.Q1038Q	PAPLN_ENST00000554301.1_Silent_p.Q1038Q|PAPLN_ENST00000381166.3_Silent_p.Q1038Q|PAPLN_ENST00000340738.5_Silent_p.Q1011Q|PAPLN_ENST00000555445.1_Silent_p.Q1022Q			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	1038	Ig-like C2-type 2.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CACACCCACAGCCTGCAAACA	0.657000													49	113					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29867071	29867071	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29867071G>A	ENST00000399218.4	-	4	1544	c.1489C>T	c.(1489-1491)Cct>Tct	p.P497S	GAREM_ENST00000269209.6_Missense_Mutation_p.P497S	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		AGAGTCCCAGGGATGGGAAGA	0.507000													43	89					0	0	1	0	0
PHYHIPL	84457	broad.mit.edu	37	10	60994167	60994167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:60994167G>A	ENST00000373880.4	+	2	474	c.210G>A	c.(208-210)tgG>tgA	p.W70*	PHYHIPL_ENST00000373878.3_Nonsense_Mutation_p.W44*	NM_032439.3	NP_115815.2	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein-like	70	Fibronectin type-III.									NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(3)|skin(1)|urinary_tract(1)	18						AGATTTCATGGGAAATGGATT	0.338000													17	86					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2350132	2350132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2350132C>T	ENST00000301732.5	-	13	2185	c.1485G>A	c.(1483-1485)ggG>ggA	p.G495G	ABCA3_ENST00000382381.3_Silent_p.G437G	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	495					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				CCCTTGGCTTCCCACACCAAT	0.547000													42	83					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204923962	204923962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204923962C>T	ENST00000367172.4	+	7	746	c.418C>T	c.(418-420)Cct>Tct	p.P140S	NFASC_ENST00000404076.1_Missense_Mutation_p.P134S|NFASC_ENST00000513543.1_Missense_Mutation_p.P134S|NFASC_ENST00000367171.4_Missense_Mutation_p.P140S|NFASC_ENST00000403080.1_Missense_Mutation_p.P140S|NFASC_ENST00000339876.6_Missense_Mutation_p.P140S|NFASC_ENST00000539706.1_Missense_Mutation_p.P134S|NFASC_ENST00000404907.1_Missense_Mutation_p.P134S|NFASC_ENST00000360049.4_Missense_Mutation_p.P134S|NFASC_ENST00000367170.4_Missense_Mutation_p.P140S|NFASC_ENST00000401399.1_Missense_Mutation_p.P140S|NFASC_ENST00000367169.4_Missense_Mutation_p.P140S|NFASC_ENST00000338586.6_Missense_Mutation_p.P140S|NFASC_ENST00000338515.6_Missense_Mutation_p.P140S			O94856	NFASC_HUMAN	neurofascin	140					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCCAGAATCTCCTCTGTGGCC	0.592000													46	136					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583945	88583945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88583945G>A	ENST00000339673.6	+	6	1114	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.E323K|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	339					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		TCCCAGCAGTGAGTCCAGCCA	0.552000													13	95					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36780080	36780080	+	Missense_Mutation	SNP	C	C	T	rs56070233	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36780080C>T	ENST00000416516.2	-	2	561	c.71G>A	c.(70-72)cGg>cAg	p.R24Q		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	24			R -> Q (in dbSNP:rs56070233).			cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TGTCAGGGCCCGGGCTTTGTT	0.567000													48	132					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215440421	215440421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215440421G>A	ENST00000427124.1	+	3	1218	c.416G>A	c.(415-417)cGa>cAa	p.R139Q	AC107218.3_ENST00000437883.1_RNA|AC107218.3_ENST00000412896.1_RNA|VWC2L_ENST00000312504.5_Silent_p.T182T			B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	0	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						CAGGAACGACGATAATTCCAG	0.463000													33	146					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104044282	104044282	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104044282T>C	ENST00000388887.2	+	11	1387	c.1183T>C	c.(1183-1185)Tat>Cat	p.Y395H		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	395	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGACAAAGCTTATGCCTGGCC	0.458000													14	44					0	0	1	0	0
FAM110B	90362	broad.mit.edu	37	8	59059522	59059522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:59059522G>A	ENST00000361488.3	+	5	1613	c.733G>A	c.(733-735)Gaa>Aaa	p.E245K	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	245						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CGACCCTGTGGAACCAGCTTG	0.607000													32	108					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23782434	23782434	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23782434G>A	ENST00000336689.3	-	3	332	c.288C>T	c.(286-288)tcC>tcT	p.S96S	ASAP3_ENST00000437606.2_Silent_p.S96S	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	96					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						GGAAGCCTGTGGACAGCTCAT	0.567000													40	90					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45807055	45807055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45807055C>T	ENST00000358525.4	-	8	1392	c.1277G>A	c.(1276-1278)aGc>aAc	p.S426N	SLC6A20_ENST00000353278.4_Missense_Mutation_p.S389N|SLC6A20_ENST00000493980.1_5'UTR|SLC6A20_ENST00000456124.2_Missense_Mutation_p.S426N	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	426					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		GGGCAGGTGGCTGGAGATGAT	0.632000													9	17					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61873986	61873986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61873986G>A	ENST00000280772.1	-	26	3136	c.2945C>T	c.(2944-2946)tCt>tTt	p.S982F	ANK3_ENST00000503366.1_Missense_Mutation_p.S983F|ANK3_ENST00000373827.2_Missense_Mutation_p.S976F|ANK3_ENST00000355288.2_Missense_Mutation_p.S116F	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	982	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TACTTACCCAGAATGAATGGG	0.348000													18	48					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47358979	47358979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47358979G>A	ENST00000545968.1	-	25	2619	c.2565C>T	c.(2563-2565)tcC>tcT	p.S855S	MYBPC3_ENST00000256993.4_Silent_p.S854S|MYBPC3_ENST00000399249.2_Silent_p.S855S	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	854	Fibronectin type-III 1.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		GGCTGGGCCTGGACATGCCGA	0.622000													20	33					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197189858	197189858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197189858C>T	ENST00000260983.2	-	6	769	c.587G>A	c.(586-588)gGg>gAg	p.G196E	HECW2_ENST00000409111.1_Intron	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	196	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TTTCTTTAGCCCAACTGCCCT	0.498000													41	91					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104709366	104709366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:104709366G>A	ENST00000406091.3	+	2	229	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K		NM_001100117.2	NP_001093587.1	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	108	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAAGATGGGAGAAGAATCACA	0.403000										HNSCC(12;0.0054)			21	58					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394087	233394087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233394087C>T	ENST00000258229.8	-	5	1755	c.1521G>A	c.(1519-1521)ggG>ggA	p.G507G	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	507						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GGCCTTCCTTCCCCACCTTAG	0.547000													18	49					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5363912	5363912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5363912G>A	ENST00000300773.2	-	1	897	c.843C>T	c.(841-843)ttC>ttT	p.F281F	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTAGTGGAGGGAACAGAAAAT	0.378000													29	65					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145427421	145427421	+	Silent	SNP	G	G	A	rs75157444	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145427421G>A	ENST00000511217.1	+	5	1198	c.1146G>A	c.(1144-1146)gcG>gcA	p.A382A	SH3RF2_ENST00000359120.4_Silent_p.A382A			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	382	SH3 3.						ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCTCTCAGCGAACATGTGAG	0.527000													41	29					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58722323	58722323	+	Silent	SNP	G	G	A	rs7478799		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58722323G>A	ENST00000300079.5	+	5	410	c.360G>A	c.(358-360)ttG>ttA	p.L120L	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Silent_p.L89L	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	89						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	AAGAAGTTTTGAAAAATTGTG	0.383000													25	50					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28116381	28116381	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28116381G>A	ENST00000354638.3	-	21	2318	c.2163C>T	c.(2161-2163)ctC>ctT	p.L721L	OCA2_ENST00000353809.5_Silent_p.L697L	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	721					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TGGCGGCTATGAGGCGCTGCT	0.577000									Oculocutaneous Albinism				19	51					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1993972	1993972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1993972C>T	ENST00000382722.5	-	11	1596	c.1234G>A	c.(1234-1236)Gag>Aag	p.E412K	CACNA2D4_ENST00000586184.1_Missense_Mutation_p.E412K|CACNA2D4_ENST00000585732.1_Missense_Mutation_p.E328K|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.E348K|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.E412K|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.E348K	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	412	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AACACCGGCTCGTAGTCCTCC	0.567000													8	21					0	0	1	0	0
TAS2R14	50840	broad.mit.edu	37	12	11091013	11091013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11091013G>A	ENST00000537503.1	-	1	849	c.794C>T	c.(793-795)tCc>tTc	p.S265F	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_5'UTR	NM_023922.1	NP_076411.1	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	265					detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	8						CATCACCTGGGAAAGAATAAT	0.423000													11	120					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101818645	101818645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101818645G>A	ENST00000375001.3	+	35	3719	c.3296G>A	c.(3295-3297)gGg>gAg	p.G1099E		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1099	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GGGCCACCGGGGCCCCCGGGG	0.622000													19	59					0	0	1	0	0
POLD2	5425	broad.mit.edu	37	7	44156455	44156455	+	Silent	SNP	G	G	A	rs142289447	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44156455G>A	ENST00000406581.2	-	7	1390	c.741C>T	c.(739-741)ctC>ctT	p.L247L	POLD2_ENST00000452185.1_Silent_p.L247L|POLD2_ENST00000223361.3_Silent_p.L247L	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	247					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						TGTGGCTGAGGAGGTTGCCAG	0.637000													18	48					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76829014	76829014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76829014C>T	ENST00000248598.5	-	1	129	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	CCDC146_ENST00000431197.1_Intron|CCDC146_ENST00000285871.4_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	33					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						TTTGCTCTTTCATCTTTAATT	0.488000													20	109					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3834887	3834887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3834887G>A	ENST00000262961.4	-	2	158	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S	ZFR2_ENST00000591965.1_5'UTR	NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	50						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		GCAGCTGGGGGAAAGGCCGGG	0.697000													8	14					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32355867	32355867	+	Missense_Mutation	SNP	C	C	T	rs144275111		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32355867C>T	ENST00000298386.2	+	10	916	c.845C>T	c.(844-846)tCg>tTg	p.S282L	RXFP2_ENST00000380314.1_Missense_Mutation_p.S282L	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	282						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TCGTGCGATTCGCTCACAGTG	0.323000													7	63					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164507045	164507045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164507045G>A	ENST00000503008.1	-	6	1255	c.279C>T	c.(277-279)ctC>ctT	p.L93L	MARCH1_ENST00000514618.1_Silent_p.L349L|MARCH1_ENST00000274056.7_Silent_p.L93L|MARCH1_ENST00000339875.5_Silent_p.L76L	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	93					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AGGGTGTGATGAGGGGGCTCT	0.537000													16	44					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64111715	64111715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64111715G>A	ENST00000356786.5	+	14	1746	c.1702G>A	c.(1702-1704)Gac>Aac	p.D568N	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000301897.4_5'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	568					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGCTGCCATGGACCCCCAGGC	0.632000													41	67					0	0	1	0	0
TRAT1	50852	broad.mit.edu	37	3	108549612	108549612	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108549612G>A	ENST00000295756.6	+	2	333	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	TRAT1_ENST00000493604.1_3'UTR|TRAT1_ENST00000426646.1_Intron	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	35					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity	p.E35K(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						CCACTATGTGGAAAAGCAACG	0.428000													46	86					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813468	106813468	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106813468C>T	ENST00000407775.2	+	8	1408	c.1158C>T	c.(1156-1158)gtC>gtT	p.V386V	ZFPM2_ENST00000520492.1_Silent_p.V254V|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Silent_p.V117V|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Silent_p.V254V|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	386					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AGCTCCATGTCCCTAGCGGCA	0.512000													60	99					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117728230	117728230	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117728230G>A	ENST00000317775.6	-	4	1539	c.852_splice	c.e4-1	p.P285_splice	NOS1_ENST00000344089.3_Splice_Site_p.P304_splice|NOS1_ENST00000338101.4_Splice_Site_p.P285_splice	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	285					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGAGGTGGGGGGCTGCAGGAG	0.552000													14	36					0	0	1	0	0
FAM89A	375061	broad.mit.edu	37	1	231155655	231155655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:231155655G>A	ENST00000366654.4	-	2	543	c.509C>T	c.(508-510)cCt>cTt	p.P170L	FAM89A_ENST00000494111.1_5'UTR|MIR1182_ENST00000408363.1_RNA	NM_198552.2	NP_940954.1	Q96GI7	FA89A_HUMAN	family with sequence similarity 89, member A	170										endometrium(1)|upper_aerodigestive_tract(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GGAGGAGACAGGCAGTGACAA	0.577000													6	64					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561402	44561402	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44561402G>A	ENST00000332567.4	-	1	586	c.234C>T	c.(232-234)ctC>ctT	p.L78L	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	78	TFIIS N-terminal.				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTCGGTCCACGAGCACCAGCT	0.642000													18	45					0	0	1	0	0
LDLRAP1	26119	broad.mit.edu	37	1	25891695	25891695	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:25891695C>T	ENST00000374338.4	+	8	898	c.779C>T	c.(778-780)tCg>tTg	p.S260L	LDLRAP1_ENST00000488127.1_3'UTR	NM_015627.2	NP_056442.2	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein 1	260	AP-2 complex binding.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGCGTTTTCGAGGTAATGC	0.562000													55	127					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46801018	46801018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46801018G>A	ENST00000230588.4	+	11	1361	c.1352G>A	c.(1351-1353)gGg>gAg	p.G451E		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	451	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			ACCAGCAAAGGGGACAAGCTT	0.483000													29	80					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117352753	117352753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117352753G>A	ENST00000321322.6	-	12	2665	c.2664C>T	c.(2662-2664)gtC>gtT	p.V888V	DSCAML1_ENST00000527706.1_Silent_p.V618V	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	828	Fibronectin type-III 1.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CAGGGTCGATGACTGTGTCCC	0.627000													24	63					0	0	1	0	0
SLC2A8	29988	broad.mit.edu	37	9	130167124	130167124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130167124C>T	ENST00000373371.3	+	8	1093	c.1004C>T	c.(1003-1005)gCc>gTc	p.A335V	SLC2A8_ENST00000373360.3_Missense_Mutation_p.A335V|SLC2A8_ENST00000485806.1_3'UTR|SLC2A8_ENST00000373352.1_Missense_Mutation_p.A72V	NM_001271712.1|NM_014580.3	NP_001258641.1|NP_055395.2	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 8	335						cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	11						AGCACGAGTGCCTTCGGCGCC	0.687000													9	42					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28534587	28534587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:28534587C>T	ENST00000357727.2	+	3	529	c.139C>T	c.(139-141)Cct>Tct	p.P47S	CREB5_ENST00000396300.2_Missense_Mutation_p.P40S|CREB5_ENST00000409603.1_Missense_Mutation_p.P14S|CREB5_ENST00000396299.2_Missense_Mutation_p.P14S	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	47					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						TTTGAAGTTTCCTTCAATAAA	0.408000													38	111					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092491	151092491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151092491C>T	ENST00000370335.1	+	3	622	c.355C>T	c.(355-357)Cat>Tat	p.H119Y	MAGEA4_ENST00000276344.2_Missense_Mutation_p.H119Y|MAGEA4_ENST00000393921.1_Missense_Mutation_p.H119Y|MAGEA4_ENST00000370340.3_Missense_Mutation_p.H119Y|MAGEA4_ENST00000370337.4_Missense_Mutation_p.H119Y|MAGEA4_ENST00000360243.2_Missense_Mutation_p.H119Y|MAGEA4_ENST00000393920.1_Missense_Mutation_p.H119Y			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	119	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGTTGGCTCATTTTCTGCT	0.517000													39	36					0	0	1	0	0
CIR1	9541	broad.mit.edu	37	2	175213483	175213483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:175213483G>A	ENST00000342016.3	-	10	1187	c.1095C>T	c.(1093-1095)agC>agT	p.S365S	CIR1_ENST00000362053.5_3'UTR	NM_004882.3	NP_004873.3	Q86X95	CIR1_HUMAN	corepressor interacting with RBPJ, 1	365	Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						TCTTCTCTGGGCTATGTTTAT	0.512000													46	127					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32932943	32932943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:32932943C>T	ENST00000383763.4	+	4	2310	c.2247C>T	c.(2245-2247)tcC>tcT	p.S749S		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	749					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACTTTGACTCCCCACGGGGTG	0.577000													8	54					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39883840	39883840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39883840G>A	ENST00000373186.4	-	3	692	c.555C>T	c.(553-555)gcC>gcT	p.A185A	MOCS1_ENST00000373195.3_Silent_p.A98A|MOCS1_ENST00000340692.5_Silent_p.A185A|MOCS1_ENST00000425303.2_Silent_p.A185A|MOCS1_ENST00000432280.2_Silent_p.A156A|MOCS1_ENST00000373188.2_Silent_p.A185A|MOCS1_ENST00000308559.7_Silent_p.A185A|MOCS1_ENST00000373175.4_Silent_p.A156A	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	185	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACTCAAACTTGGCAGGCACCA	0.597000													4	15					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167182137	167182137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167182137G>A	ENST00000519204.1	+	1	197	c.79G>A	c.(79-81)Ggc>Agc	p.G27S	TENM2_ENST00000545108.1_Intron|TENM2_ENST00000518659.1_Intron|TENM2_ENST00000520393.1_Intron|TENM2_ENST00000520394.1_Missense_Mutation_p.G27S					teneurin transmembrane protein 2																		ATGGAGACCCGGCAGTACCTC	0.527000													76	206					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933284	44933284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44933284C>T	ENST00000291187.4	-	6	1976	c.1654G>A	c.(1654-1656)Gac>Aac	p.D552N	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Missense_Mutation_p.D558N	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				ATGTGGAGGTCGGAGCTCCGG	0.542000													33	80					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36933246	36933246	+	Missense_Mutation	SNP	G	G	A	rs144754091		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36933246G>A	ENST00000373103.1	-	15	2418	c.1871C>T	c.(1870-1872)tCg>tTg	p.S624L	CSF3R_ENST00000440588.2_Missense_Mutation_p.S624L|CSF3R_ENST00000331941.5_Missense_Mutation_p.S624L|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000373106.1_Missense_Mutation_p.S624L|CSF3R_ENST00000361632.4_Missense_Mutation_p.S624L|CSF3R_ENST00000373104.1_Missense_Mutation_p.S624L|CSF3R_ENST00000418048.2_Missense_Mutation_p.S624L|CSF3R_ENST00000338937.5_Intron	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	624					cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GTGTAGCTCCGACCCCTCTGC	0.602000													9	35					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160100247	160100247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160100247C>T	ENST00000361216.3	+	13	1776	c.1687C>T	c.(1687-1689)Cct>Tct	p.P563S	ATP1A2_ENST00000392233.3_Missense_Mutation_p.P563S|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	563					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGGAAAGTTTCCTCGGGGCTT	0.552000													9	82					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50596572	50596572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50596572C>T	ENST00000262794.5	+	23	3236	c.3153C>T	c.(3151-3153)gcC>gcT	p.A1051A	MOV10L1_ENST00000354853.2_Silent_p.A94A|MOV10L1_ENST00000545383.1_Silent_p.A1051A|MOV10L1_ENST00000540615.1_Silent_p.A1031A|MOV10L1_ENST00000395843.1_Silent_p.A94A|MOV10L1_ENST00000395852.1_Silent_p.A178A|MOV10L1_ENST00000395858.3_Silent_p.A1051A	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	1051					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GCCTCCTGGCCCACAGCATCT	0.652000													13	55					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74328294	74328294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74328294C>T	ENST00000409262.3	+	9	3974	c.3974C>T	c.(3973-3975)tCg>tTg	p.S1325L		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1325							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGTGTGTTCTCGTCTGGGGAG	0.612000													9	28					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236925911	236925911	+	Missense_Mutation	SNP	G	G	A	rs142646143		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236925911G>A	ENST00000366578.4	+	21	2843	c.2677G>A	c.(2677-2679)Gat>Aat	p.D893N	ACTN2_ENST00000542672.1_Missense_Mutation_p.D893N|ACTN2_ENST00000546208.1_Missense_Mutation_p.D387N	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	893					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding	p.D893Y(2)		endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGGGGAGAGCGATCTGTGATG	0.507000													11	29					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63137657	63137657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63137657C>T	ENST00000279178.3	+	1	378	c.129C>T	c.(127-129)ttC>ttT	p.F43F	SLC22A9_ENST00000310969.4_Silent_p.F43F	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	43					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						TCACTGCATTCATACCTGGCC	0.483000													80	175					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131916027	131916027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131916027C>T	ENST00000286355.5	-	7	3994	c.1902G>A	c.(1900-1902)ggG>ggA	p.G634G	ADCY8_ENST00000377928.3_Silent_p.G634G	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	634					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CATTCTGTTTCCCCACGATAT	0.498000										HNSCC(32;0.087)			20	63					0	0	1	0	0
NFAM1	150372	broad.mit.edu	37	22	42807450	42807450	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42807450G>A	ENST00000329021.5	-	2	451	c.414C>T	c.(412-414)tcC>tcT	p.S138S		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	138	Ig-like V-type.				B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			large_intestine(1)|lung(3)	4						CTCTCACCGTGGAGTGTGGCC	0.597000													17	20					0	0	1	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307027	39307027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39307027G>A	ENST00000541347.1	-	2	1213	c.974C>T	c.(973-975)tCc>tTc	p.S325F	CX3CR1_ENST00000358309.3_Missense_Mutation_p.S357F|CX3CR1_ENST00000542107.1_Missense_Mutation_p.S325F|CX3CR1_ENST00000399220.2_Missense_Mutation_p.S325F	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	325					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		TTCAGATGAGGAGAAATCAAC	0.478000													59	110					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269485	150269485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150269485G>A	ENST00000255945.2	+	3	502	c.327G>A	c.(325-327)ctG>ctA	p.L109L	GIMAP4_ENST00000461940.1_Silent_p.L123L|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	109							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCATTCTTCTGACCTCCCCAG	0.507000													21	77					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439352	110439352	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110439352G>A	ENST00000378402.5	+	25	3071	c.2967G>A	c.(2965-2967)tgG>tgA	p.W989*		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	989					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACATCAAATGGAGAAGCACCT	0.488000										HNSCC(38;0.096)			15	32					0	0	1	0	0
VIPR1	7433	broad.mit.edu	37	3	42577767	42577767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42577767G>A	ENST00000433647.1	+	14	1869	c.1245G>A	c.(1243-1245)ctG>ctA	p.L415L	VIPR1_ENST00000438259.2_Silent_p.L246L|VIPR1_ENST00000543411.1_Silent_p.L408L|VIPR1_ENST00000325123.4_Silent_p.L456L	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	456					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		AAGTCTCCCTGGTCTGACCAC	0.726000													4	3					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731807	140731807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140731807C>T	ENST00000523390.1	+	1	1980	c.1980C>T	c.(1978-1980)ttC>ttT	p.F660F	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCTAATCTTCGCGGATAGCC	0.657000													40	116					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815429	106815429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106815429G>A	ENST00000407775.2	+	8	3369	c.3119G>A	c.(3118-3120)gGa>gAa	p.G1040E	ZFPM2_ENST00000520492.1_Missense_Mutation_p.G908E|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.G771E|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.G908E|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	1040					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AAAAATCGAGGAATGGTAATA	0.473000													7	47					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136584084	136584084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136584084C>T	ENST00000371872.4	-	7	1253	c.996G>A	c.(994-996)gaG>gaA	p.E332E	SARDH_ENST00000439388.1_Silent_p.E332E|SARDH_ENST00000371867.1_Silent_p.E243E|SARDH_ENST00000422262.2_Silent_p.E164E	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	332					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGGGGTTGGCCTCATAGCCAC	0.572000													25	49					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69683801	69683801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69683801G>A	ENST00000265403.7	+	2	800	c.773G>A	c.(772-774)cGa>cAa	p.R258Q	UGT2B10_ENST00000458688.2_Missense_Mutation_p.R174Q	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	258					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TGGCTTATGCGAAACTCCTGG	0.383000													71	128					0	0	1	0	0
DUSP13	51207	broad.mit.edu	37	10	76868887	76868887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76868887C>T	ENST00000372702.3	-	1	92	c.29G>A	c.(28-30)gGg>gAg	p.G10E	DUSP13_ENST00000372700.3_Missense_Mutation_p.G10E|DUSP13_ENST00000607009.1_5'UTR|DUSP13_ENST00000491677.2_5'UTR|DUSP13_ENST00000607131.1_5'UTR			Q6B8I1	MDSP_HUMAN	dual specificity phosphatase 13	10						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	8	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GTCCTCTCCCCCCAGCTCTGG	0.637000													20	31					0	0	1	0	0
CNN2	1265	broad.mit.edu	37	19	1037846	1037846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1037846C>T	ENST00000263097.4	+	7	1240	c.877C>T	c.(877-879)Ccg>Tcg	p.P293S	CNN2_ENST00000565096.2_Missense_Mutation_p.P282S|CNN2_ENST00000562958.2_Missense_Mutation_p.P314S|CNN2_ENST00000348419.3_Missense_Mutation_p.P254S|CNN2_ENST00000606983.1_3'UTR	NM_004368.2	NP_004359.1	Q99439	CNN2_HUMAN	calponin 2	293					actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCCCGGACCCGGGGGAGGT	0.657000													33	97					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20996782	20996782	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20996782C>T	ENST00000261383.3	-	48	7281	c.7282G>A	c.(7282-7284)Ggc>Agc	p.G2428S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2428	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGCAGGTGGCCTTTGTCCTGC	0.542000													21	33					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91312713	91312713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91312713C>T	ENST00000355112.3	+	12	2570	c.2452C>T	c.(2452-2454)Cgc>Tgc	p.R818C	BLM_ENST00000560136.1_3'UTR|BLM_ENST00000560509.1_Missense_Mutation_p.R818C	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	818	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GAATATGCTTCGCCAGAAGTT	0.428000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				65	92					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170062088	170062088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170062088C>T	ENST00000263816.3	-	41	7901	c.7616G>A	c.(7615-7617)gGa>gAa	p.G2539E		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2539					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GCGGAAGTTTCCTCCCAATGT	0.493000													32	95					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228559458	228559458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228559458C>T	ENST00000570156.2	+	105	23924	c.23850C>T	c.(23848-23850)gcC>gcT	p.A7950A	OBSCN_ENST00000366707.4_Silent_p.A4627A|OBSCN_ENST00000422127.1_Silent_p.A6993A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6993					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCGGGGGGGCCCCTATCAGGG	0.692000													8	46					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100677717	100677717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100677717C>T	ENST00000306151.4	+	3	3084	c.3020C>T	c.(3019-3021)cCt>cTt	p.P1007L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1007	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAACAACTCCTGTTGACTCC	0.522000													195	550					0	0	1	0	0
PRSS50	29122	broad.mit.edu	37	3	46757161	46757161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46757161G>A	ENST00000460241.1	-	8	2004	c.334C>T	c.(334-336)Ccc>Tcc	p.P112S	PRSS50_ENST00000315170.7_Missense_Mutation_p.P112S			Q9UI38	TSP50_HUMAN	protease, serine, 50	112	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						CTGAGGGTGGGGTCCTGCTCG	0.637000													3	13					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14368958	14368958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14368958C>T	ENST00000344204.4	+	17	3040	c.3016C>T	c.(3016-3018)Cgc>Tgc	p.R1006C	TRIO_ENST00000537187.1_Missense_Mutation_p.R1006C|TRIO_ENST00000509967.2_Missense_Mutation_p.R957C	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1006					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GATGGAAGATCGCCTCAAGCT	0.532000													41	98					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10689727	10689727	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:10689727G>T	ENST00000302079.6	-	45	7083	c.7084C>A	c.(7084-7086)Ctg>Atg	p.L2362M	PIEZO2_ENST00000538948.1_Missense_Mutation_p.L319M|PIEZO2_ENST00000285141.4_Missense_Mutation_p.L217M|PIEZO2_ENST00000580640.1_Missense_Mutation_p.L2387M|PIEZO2_ENST00000503781.3_Missense_Mutation_p.L2362M			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2362						integral to membrane	ion channel activity										CAGCTGGACAGGCTCAAAGTT	0.527000													9	78					2.17888e-05	2.183e-05	1	1	0
GLI2	2736	broad.mit.edu	37	2	121747721	121747721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:121747721G>A	ENST00000452319.1	+	14	4291	c.4231G>A	c.(4231-4233)Gaa>Aaa	p.E1411K	GLI2_ENST00000361492.4_Missense_Mutation_p.E1411K|GLI2_ENST00000314490.11_Intron			P10070	GLI2_HUMAN	GLI family zinc finger 2	1411					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GTCCAGTCAGGAAACAGCAGA	0.697000													11	35					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109935691	109935691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109935691C>T	ENST00000342494.3	+	10	1377	c.782C>T	c.(781-783)cCt>cTt	p.P261L	UBE3B_ENST00000434735.2_Missense_Mutation_p.P261L|UBE3B_ENST00000280774.5_Missense_Mutation_p.P261L	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	261					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						ATGTCTGTGCCTGCTCTGGTG	0.478000													29	89					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404085	124404085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:124404085G>A	ENST00000303921.2	-	1	1596	c.946C>T	c.(946-948)Ccg>Tcg	p.P316S		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	316						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						ATGACCAGCGGAAGGCAGAAG	0.537000													62	131					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229772115	229772115	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:229772115C>T	ENST00000258243.2	+	4	1891	c.1755C>T	c.(1753-1755)gcC>gcT	p.A585A		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	585						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						CCCTGCTGGCCCTTCTCCCGG	0.617000													55	148					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36218811	36218811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36218811C>T	ENST00000222270.7	+	18	4422	c.4422C>T	c.(4420-4422)atC>atT	p.I1474I	WBP7_ENST00000420124.1_Silent_p.I1474I|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					TGGTGGGCATCCTCATGCGGC	0.627000													8	13					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142612703	142612703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142612703C>T	ENST00000265310.1	-	9	1506	c.1158G>A	c.(1156-1158)ctG>ctA	p.L386L		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	386					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity	p.L386L(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCTCCCCCACCAGCCTGATGA	0.537000													12	38					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136062737	136062737	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:136062737G>C	ENST00000383202.2	-	30	3639	c.3383C>G	c.(3382-3384)cCc>cGc	p.P1128R	STAG1_ENST00000536929.1_Missense_Mutation_p.P712R|STAG1_ENST00000236698.5_Missense_Mutation_p.P1128R|STAG1_ENST00000434713.2_Missense_Mutation_p.P868R	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1128					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GTCTCCCATGGGCCGACTGTT	0.468000													28	85					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898704	36898704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36898704C>T	ENST00000301807.6	-	12	2624	c.727G>A	c.(727-729)Gag>Aag	p.E243K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E793K|TRANK1_ENST00000428977.2_Missense_Mutation_p.E243K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	793					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GAAGTGCACTCGATCTCCCAG	0.493000													105	268					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121279119	121279119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121279119G>A	ENST00000297848.3	+	25	3340	c.3070G>A	c.(3070-3072)Gaa>Aaa	p.E1024K	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.E929K|COL14A1_ENST00000309791.4_Missense_Mutation_p.E1024K	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1024					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACCAGCAAAAGAAGGTAAAAG	0.363000													28	167					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39087490	39087490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:39087490G>A	ENST00000331366.5	-	15	1208	c.1112C>T	c.(1111-1113)cCa>cTa	p.P371L	CPNE8_ENST00000538596.2_Missense_Mutation_p.P40L|CPNE8_ENST00000360449.3_Missense_Mutation_p.P359L	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	371	VWFA.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CCTTCCATCTGGAGGCAGTTT	0.348000													19	133					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79392661	79392661	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:79392661G>A	ENST00000370742.3	-	8	1056	c.993C>T	c.(991-993)gtC>gtT	p.V331V		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	331					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CTGAAGATATGACTCTTTCCT	0.318000													25	71					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22675776	22675776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:22675776C>T	ENST00000376603.2	+	5	936	c.794C>T	c.(793-795)tCg>tTg	p.S265L	SPAG6_ENST00000376601.1_Intron|SPAG6_ENST00000538630.1_Missense_Mutation_p.S164L|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376624.3_Missense_Mutation_p.S189L|SPAG6_ENST00000313311.6_Missense_Mutation_p.S189L			O75602	SPAG6_HUMAN	sperm associated antigen 6	189					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						ATTGCTGCTTCGGCCCTCAGT	0.483000													17	91					0	0	1	0	0
HS1BP3	64342	broad.mit.edu	37	2	20838369	20838369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:20838369G>A	ENST00000402541.1	-	4	464	c.450C>T	c.(448-450)tcC>tcT	p.S150S	HS1BP3_ENST00000304031.3_Silent_p.S150S			Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	150					cell communication		phosphatidylinositol binding			endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	15	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGGACAGAGGAATCTCTGC	0.567000													16	43					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86523440	86523440	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:86523440G>A	ENST00000297814.2	-	3	569	c.426C>T	c.(424-426)gaC>gaT	p.D142D	KIF27_ENST00000413982.1_Silent_p.D142D|KIF27_ENST00000334204.2_Silent_p.D142D	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	142	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						GATCTCTTAGGTCTTCCTTGT	0.363000													32	112					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159688919	159688919	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159688919G>A	ENST00000297267.9	+	22	5730	c.5530G>A	c.(5530-5532)Ggg>Agg	p.G1844R	FNDC1_ENST00000340366.6_Missense_Mutation_p.G1781R	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1844						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TGGAAGAACAGGGCCTCAGTC	0.438000													5	16					0	0	1	0	0
KBTBD11	9920	broad.mit.edu	37	8	1950698	1950698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1950698C>T	ENST00000320248.3	+	2	2306	c.1340C>T	c.(1339-1341)gCc>gTc	p.A447V		NM_014867.2	NP_055682.1	O94819	KBTBB_HUMAN	kelch repeat and BTB (POZ) domain containing 11	447										lung(1)|pancreas(1)	2		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.72e-05)|READ - Rectum adenocarcinoma(644;0.0929)|COAD - Colon adenocarcinoma(149;0.134)		ggcgccTTCGCCGTGGCGCAT	0.736000													3	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179659733	179659733	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179659733G>A	ENST00000589042.1	-	7	1385	c.1161C>T	c.(1159-1161)acC>acT	p.T387T	TTN_ENST00000342992.6_Silent_p.T387T|TTN_ENST00000360870.5_Silent_p.T387T|TTN_ENST00000460472.2_Silent_p.T387T|TTN_ENST00000342175.6_Silent_p.T387T|TTN_ENST00000359218.5_Silent_p.T387T|TTN_ENST00000591111.1_Silent_p.T387T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	387							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACCACTGATGGTCACTTGCT	0.557000													24	73					0	0	1	0	0
AQP10	89872	broad.mit.edu	37	1	154296130	154296130	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154296130C>T	ENST00000484864.1	+	5	591	c.555C>T	c.(553-555)gtC>gtT	p.V185V	AQP10_ENST00000324978.3_Silent_p.V185V|AQP10_ENST00000355197.4_3'UTR			Q96PS8	AQP10_HUMAN	aquaporin 10	185					response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|stomach(2)|upper_aerodigestive_tract(1)	23	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACAAGGGAGTCCCTGCGGGTC	0.622000													47	142					0	0	1	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686626	108686626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108686626C>T	ENST00000397688.2	-	3	477	c.108G>A	c.(106-108)gtG>gtA	p.V36V	CMKLR1_ENST00000550402.1_Silent_p.V38V|CMKLR1_ENST00000312143.7_Silent_p.V38V|CMKLR1_ENST00000412676.1_Silent_p.V38V|CMKLR1_ENST00000552995.1_Silent_p.V36V	NM_004072.2	NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	38					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						AGATCCTGGTCACCCTGGCTT	0.473000													20	47					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43596891	43596891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:43596891G>A	ENST00000292246.3	-	10	1717	c.1547C>T	c.(1546-1548)cCa>cTa	p.P516L	ANO10_ENST00000451430.2_Missense_Mutation_p.P405L|ANO10_ENST00000414522.2_Missense_Mutation_p.P516L|ANO10_ENST00000396091.3_Missense_Mutation_p.P450L|ANO10_ENST00000350459.4_Missense_Mutation_p.P326L	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	516					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						AGCTGCTAATGGGTAAACACA	0.383000													24	83					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37256298	37256298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37256298C>T	ENST00000310758.4	-	11	1430	c.783G>A	c.(781-783)gaG>gaA	p.E261E	ELMO1_ENST00000448602.1_Silent_p.E261E|ELMO1_ENST00000442504.1_Silent_p.E261E	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	261					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TATTCGCCATCTCCTGTGGAA	0.478000													31	69					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25448272	25448272	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25448272G>A	ENST00000424208.1	+	0	2118				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CTGGTGTGCTGAAGCTCAGGC	0.642000													33	66					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39226093	39226093	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39226093A>G	ENST00000340369.3	-	2	5072	c.4844T>C	c.(4843-4845)gTt>gCt	p.V1615A	XIRP1_ENST00000421646.1_Missense_Mutation_p.V298A|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1615							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTGGCATTCAACCTTGGCTTG	0.572000													48	134					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44983754	44983754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44983754G>A	ENST00000372227.1	-	6	1075	c.535C>T	c.(535-537)Cgc>Tgc	p.R179C	SLC35C2_ENST00000243896.2_Missense_Mutation_p.R179C|SLC35C2_ENST00000372230.5_Missense_Mutation_p.R179C|SLC35C2_ENST00000372229.1_Missense_Mutation_p.R46C|SLC35C2_ENST00000317734.8_Missense_Mutation_p.R158C|SLC35C2_ENST00000543605.1_Missense_Mutation_p.R208C			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	179					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				AGGGTCCAGCGAATGCCACCG	0.622000													33	94					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774677	121774677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121774677C>T	ENST00000264808.3	-	3	436	c.196G>A	c.(196-198)Gaa>Aaa	p.E66K	PRDM5_ENST00000428209.2_Missense_Mutation_p.E66K|PRDM5_ENST00000515109.1_Missense_Mutation_p.E66K|PRDM5_ENST00000394435.2_Missense_Mutation_p.E66K	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	66	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TACAAAACTTCTCCCTTACTC	0.453000													68	307					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10140504	10140504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10140504C>T	ENST00000287647.3	+	43	4379	c.4286C>T	c.(4285-4287)tCt>tTt	p.S1429F	FANCD2_ENST00000383806.1_Intron|FANCD2_ENST00000383807.1_Intron|FANCD2OS_ENST00000524279.1_Intron|FANCD2_ENST00000419585.1_Intron	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1429					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ACTGAGGTATCTCTACAAAAC	0.448000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				32	68					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27121488	27121488	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27121488G>A	ENST00000288699.6	+	2	279	c.121G>A	c.(121-123)Gag>Aag	p.E41K	DPYSL5_ENST00000401478.1_Missense_Mutation_p.E41K	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	41					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGGGCCGCGAGCTCATGAT	0.582000													23	67					0	0	1	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47653014	47653014	+	Silent	SNP	G	G	A	rs17850898		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47653014G>A	ENST00000294338.2	-	2	275	c.153C>T	c.(151-153)aaC>aaT	p.N51N	PDZK1IP1_ENST00000371885.1_Silent_p.N51N	NM_005764.3	NP_005755.1	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	51				N -> K (in Ref. 5; AAH12303).		integral to membrane				endometrium(1)|lung(1)|prostate(1)	3						ACCAGAAGTGGTTGACTGCAA	0.612000													14	38					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96824616	96824616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96824616G>A	ENST00000371270.3	-	4	677	c.583C>T	c.(583-585)Ctc>Ttc	p.L195F	CYP2C8_ENST00000539050.1_Missense_Mutation_p.L109F|CYP2C8_ENST00000535898.1_Missense_Mutation_p.L93F	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	195					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding	p.L195V(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	ATCAGGGTGAGAAAATTCTGA	0.408000													26	97					0	0	1	0	0
SLC38A1	81539	broad.mit.edu	37	12	46633526	46633526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:46633526C>T	ENST00000398637.5	-	3	752	c.58G>A	c.(58-60)Gag>Aag	p.E20K	SLC38A1_ENST00000552197.1_Missense_Mutation_p.E20K|SLC38A1_ENST00000549049.1_Missense_Mutation_p.E20K|SLC38A1_ENST00000439706.1_Missense_Mutation_p.E20K|SLC38A1_ENST00000549633.1_Intron|SLC38A1_ENST00000546893.1_Missense_Mutation_p.E20K	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	20					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			TTATCATCCTCGGGCACTGTC	0.353000													29	104					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226733	158226733	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158226733C>T	ENST00000289429.5	+	4	1295	c.762C>T	c.(760-762)ccC>ccT	p.P254P		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	254	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	ACATCTTGCCCAGTGCTGATG	0.622000													23	109					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179733990	179733990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179733990C>T	ENST00000420890.2	-	15	2365	c.2248G>A	c.(2248-2250)Gag>Aag	p.E750K	CCDC141_ENST00000295723.5_Missense_Mutation_p.E175K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	175							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCAGTTAACTCCTCTGATTCT	0.338000													9	64					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743049	26743049	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26743049A>G	ENST00000396005.3	-	1	522	c.213T>C	c.(211-213)ccT>ccC	p.P71P	SLC5A12_ENST00000280467.6_Silent_p.P71P	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	71					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						AGACTTCAGAAGGGGTCCCCA	0.522000													21	63					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40773171	40773171	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40773171C>T	ENST00000372748.3	-	19	1051	c.954_splice	c.e19-1	p.G319_splice		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	319	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			CCTGCACTGCCCTGGGATAGA	0.592000													10	23					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234873392	234873392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234873392C>T	ENST00000324695.4	+	14	1910	c.1870C>T	c.(1870-1872)Cgg>Tgg	p.R624W	TRPM8_ENST00000433712.2_Missense_Mutation_p.R312W	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	624						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTACGAGACCCGGGCTGTTGG	0.582000													20	72					0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128896701	128896701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:128896701G>A	ENST00000371106.3	+	19	1887	c.1695G>A	c.(1693-1695)ggG>ggA	p.G565G		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	565					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						GAGAATTTGGGATCCGTCTCG	0.542000													36	24					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74328067	74328067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74328067C>T	ENST00000409262.3	+	9	3747	c.3747C>T	c.(3745-3747)ccC>ccT	p.P1249P		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1249							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ACCCCTCCCCCTTTGCCCAGA	0.622000													5	9					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115544705	115544705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:115544705C>T	ENST00000310836.6	+	2	1191	c.669C>T	c.(667-669)aaC>aaT	p.N223N	UGT8_ENST00000394511.3_Silent_p.N223N	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	223					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		AGAAGTACAACCTGCTGCCAG	0.463000													44	78					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62289169	62289169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:62289169C>T	ENST00000519846.1	+	4	933	c.461C>T	c.(460-462)tCc>tTc	p.S154F	CLVS1_ENST00000518592.1_5'UTR|CLVS1_ENST00000325897.4_Missense_Mutation_p.S154F			Q8IUQ0	CLVS1_HUMAN	clavesin 1	154	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TGCAGGAACTCCTTCACAGAC	0.493000													16	95					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553072	140553072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140553072C>T	ENST00000231137.3	+	1	830	c.656C>T	c.(655-657)tCt>tTt	p.S219F		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		219	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACGGCGGCTCTCCTCCAAGA	0.547000													20	68					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657294	72657294	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72657294C>T	ENST00000425256.1	-	0	2617					NR_002164.1																						caggagttttctctccatcgc	0.448000													45	82					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354073	57354073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57354073C>T	ENST00000314922.3	-	2	638	c.562G>A	c.(562-564)Ggc>Agc	p.G188S	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.G188S	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	188					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CTCATGAAGCCCCCATATCTC	0.517000													53	130					0	0	1	0	0
GLRA1	2741	broad.mit.edu	37	5	151304099	151304099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:151304099G>A	ENST00000274576.4	-	1	304	c.12C>T	c.(10-12)ttC>ttT	p.F4F	GLRA1_ENST00000545569.1_5'UTR|GLRA1_ENST00000455880.2_Silent_p.F4F|GLRA1_ENST00000471351.2_5'UTR	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	4					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAAGAGTATTGAAGCTGTACA	0.428000													34	139					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71465309	71465309	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71465309C>T	ENST00000322937.6	+	5	343	c.240C>T	c.(238-240)ctC>ctT	p.L80L	AMBN_ENST00000449493.2_Silent_p.L80L	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	80					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			ACGGTCTCCTCCCACCACATT	0.373000													24	61					0	0	1	0	0
HMGCS2	3158	broad.mit.edu	37	1	120301848	120301848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120301848G>A	ENST00000369406.3	-	4	792	c.743C>T	c.(742-744)tCg>tTg	p.S248L	HMGCS2_ENST00000544913.2_Missense_Mutation_p.S206L|HMGCS2_ENST00000476640.1_Intron	NM_005518.3	NP_005509.1	P54868	HMCS2_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	248					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		TGGGTACTCCGAGGCCAAATT	0.468000													36	69					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124345685	124345685	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124345685G>A	ENST00000368909.3	+	16	1675	c.1569G>A	c.(1567-1569)tgG>tgA	p.W523*	DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368955.3_Nonsense_Mutation_p.W513*|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000344338.3_Nonsense_Mutation_p.W513*|DMBT1_ENST00000338354.3_Nonsense_Mutation_p.W523*	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	523	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATGACAGCTGGGACACCAATG	0.617000													161	376					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77431653	77431653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77431653G>A	ENST00000451710.3	-	11	1477	c.1240C>T	c.(1240-1242)Ctg>Ttg	p.L414L	TRPM6_ENST00000376864.4_Silent_p.L414L|TRPM6_ENST00000449912.2_Silent_p.L409L|TRPM6_ENST00000360774.1_Silent_p.L414L|TRPM6_ENST00000376871.3_Silent_p.L414L|TRPM6_ENST00000361255.3_Silent_p.L409L|TRPM6_ENST00000376872.3_Silent_p.L414L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	414					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GCCATTGCCAGATTTAATTGC	0.363000													24	78					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64116835	64116835	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64116835G>A	ENST00000301897.4	+	0	1017				CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000356786.5_Silent_p.E883E|CCDC88B_ENST00000359902.2_Silent_p.E35E			A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B						microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGGGCAAGGAGTTGGGGGACC	0.637000													7	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069180	9069180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9069180G>A	ENST00000397910.4	-	3	18469	c.18266C>T	c.(18265-18267)tCa>tTa	p.S6089L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6091	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTGTAGTTGAGTTCATCAC	0.488000													15	30					0	0	1	0	0
PTHLH	5744	broad.mit.edu	37	12	28116375	28116375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:28116375G>A	ENST00000535992.1	-	3	776	c.430C>T	c.(430-432)Cgc>Tgc	p.R144C	RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000201015.4_Missense_Mutation_p.R144C|PTHLH_ENST00000354417.3_Missense_Mutation_p.R144C|PTHLH_ENST00000395868.3_Missense_Mutation_p.R144C|PTHLH_ENST00000545234.1_Missense_Mutation_p.R144C|PTHLH_ENST00000395872.1_Missense_Mutation_p.R144C|PTHLH_ENST00000538310.1_Missense_Mutation_p.R144C|PTHLH_ENST00000539239.1_Missense_Mutation_p.R144C			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	144					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					CAGGCAGAGCGAGTTCGCCGT	0.552000													35	74					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488194	24488194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:24488194C>T	ENST00000264463.4	-	12	2452	c.1945G>A	c.(1945-1947)Gat>Aat	p.D649N	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	649					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TCTCTGATATCTTCTTTTGAC	0.433000										HNSCC(23;0.051)			18	87					0	0	1	0	0
CHST1	8534	broad.mit.edu	37	11	45671842	45671842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:45671842G>A	ENST00000308064.2	-	4	1302	c.632C>T	c.(631-633)cCc>cTc	p.P211L		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	211					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GTTCACCTCGGGCACGCGCAC	0.682000													27	23					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420360	55420360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55420360G>A	ENST00000242994.3	+	2	515	c.137G>A	c.(136-138)aGc>aAc	p.S46N		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	46					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						ATGCTCAGCAGCTTAACTGAA	0.468000													18	43					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113955458	113955458	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113955458G>A	ENST00000245796.6	+	14	2787	c.2592G>A	c.(2590-2592)acG>acA	p.T864T	PSD4_ENST00000441564.2_Silent_p.T835T	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	864	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCTGCGCACGGCTGACTGGC	0.657000													11	23					0	0	1	0	0
UPK3A	7380	broad.mit.edu	37	22	45689189	45689189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45689189C>T	ENST00000216211.4	+	5	731	c.699C>T	c.(697-699)agC>agT	p.S233S	UPK3A_ENST00000396082.2_Silent_p.S112S	NM_006953.3	NP_008884.1	O75631	UPK3A_HUMAN	uroplakin 3A	233					epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane				kidney(1)|large_intestine(1)|lung(2)|skin(1)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TTGCCCTCAGCCTCGTGTAAG	0.632000													25	74					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148932899	148932899	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:148932899G>A	ENST00000539543.1	+	0	155					NR_027355.1																						CTCAGTCTGCGGCCAAGACTC	0.617000													8	148					0	0	1	0	0
FSTL1	11167	broad.mit.edu	37	3	120122201	120122201	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120122201C>T	ENST00000295633.3	-	8	938	c.581_splice	c.e8-1	p.R194_splice	FSTL1_ENST00000424703.2_Splice_Site_p.R159_splice	NM_007085.4	NP_009016.1	Q12841	FSTL1_HUMAN	follistatin-like 1	194	EF-hand 2.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		CACAGAGTCCCCTGAAACAAA	0.468000													5	67					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105173304	105173304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105173304C>T	ENST00000392634.4	+	7	1013	c.901C>T	c.(901-903)Ctg>Ttg	p.L301L	INF2_ENST00000330634.7_Silent_p.L301L	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	301	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CCTCCTGCACCTGGAGCCCAC	0.726000													7	17					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94927321	94927321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94927321C>T	ENST00000357742.4	+	12	1653	c.1653C>T	c.(1651-1653)aaC>aaT	p.N551N	MCTP2_ENST00000451018.3_Silent_p.N551N|MCTP2_ENST00000331706.4_Silent_p.N139N|MCTP2_ENST00000557742.1_Silent_p.N139N	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	551	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TCTACAAAAACCTCAACCCTG	0.438000													21	27					0	0	1	0	0
EXO1	9156	broad.mit.edu	37	1	242042065	242042065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:242042065C>T	ENST00000366548.3	+	13	2122	c.1529C>T	c.(1528-1530)tCa>tTa	p.S510L	EXO1_ENST00000518483.1_Missense_Mutation_p.S510L|EXO1_ENST00000348581.5_Missense_Mutation_p.S510L	NM_130398.3	NP_569082.2	Q9UQ84	EXO1_HUMAN	exonuclease 1	510					meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TTTTGCAGTTCAGATTCTACT	0.343000								Editing and processing nucleases					12	31					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10602129	10602129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10602129C>T	ENST00000547195.1	-	19	2595	c.2095G>A	c.(2095-2097)Gaa>Aaa	p.E699K	MRVI1_ENST00000531107.1_Missense_Mutation_p.E782K|MRVI1-AS1_ENST00000529979.1_RNA|MRVI1_ENST00000552103.1_Missense_Mutation_p.E699K|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000421747.1_Missense_Mutation_p.E781K|MRVI1_ENST00000558540.1_Missense_Mutation_p.E475K|MRVI1_ENST00000527509.2_Missense_Mutation_p.E699K|MRVI1_ENST00000545852.1_Missense_Mutation_p.E475K|MRVI1_ENST00000436272.1_Missense_Mutation_p.E763K|MRVI1-AS1_ENST00000529829.1_RNA|MRVI1_ENST00000541483.1_Missense_Mutation_p.E584K|MRVI1_ENST00000423302.2_Missense_Mutation_p.E790K|MRVI1_ENST00000424001.1_Missense_Mutation_p.E475K|MRVI1_ENST00000534266.2_Missense_Mutation_p.E475K	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	763					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTTAGACCTTCTTGGAATCTG	0.498000													14	107					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76332544	76332544	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76332544C>T	ENST00000312916.7	+	4	1062	c.681_splice	c.e4+1	p.S227_splice		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	227					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		TATTATGATTCTGTAAGTATC	0.438000													6	79					0	0	1	0	0
FAM126A	84668	broad.mit.edu	37	7	22999935	22999935	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:22999935G>A	ENST00000432176.2	-	10	1163	c.931C>T	c.(931-933)Cga>Tga	p.R311*	FAM126A_ENST00000409923.1_Nonsense_Mutation_p.R311*|FAM126A_ENST00000498833.1_5'UTR	NM_032581.3	NP_115970.2	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	311						cytoplasm|membrane	signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|urinary_tract(2)	23						CTTGATATTCGAGAGGAAGTT	0.388000													41	226					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39087397	39087397	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39087397G>A	ENST00000400482.3	-	3	652	c.63C>T	c.(61-63)gtC>gtT	p.V21V	KCNJ6_ENST00000288309.6_Silent_p.V21V	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	21					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CTGGGCTTTCGACGTCCTGAT	0.517000													22	29					0	0	1	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113202003	113202003	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113202003G>A	ENST00000261965.3	-	10	1285	c.1099C>T	c.(1099-1101)Ctc>Ttc	p.L367F	TUBGCP3_ENST00000375669.3_Missense_Mutation_p.L367F	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	367					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CAAACCAGGAGGCGCCGAAGT	0.473000													11	60					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175117	140175117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140175117G>A	ENST00000526136.1	+	1	568	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	PCDHA2_ENST00000378132.1_Missense_Mutation_p.E190K|PCDHA2_ENST00000520672.2_Missense_Mutation_p.E190K|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1												p.E190K(4)		NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAACTAAGCGAATCTTTGTC	0.458000													38	93					0	0	1	0	0
SUSD4	55061	broad.mit.edu	37	1	223465828	223465828	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:223465828C>T	ENST00000343846.3	-	2	947	c.314G>A	c.(313-315)gGa>gAa	p.G105E	SUSD4_ENST00000454695.2_5'UTR|SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000344029.6_Missense_Mutation_p.G105E|SUSD4_ENST00000366878.4_Missense_Mutation_p.G105E			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	105	Sushi 1.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		GCCTAGGGTTCCATTAAAATG	0.478000													65	146					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169550939	169550939	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169550939G>A	ENST00000340806.6	+	4	1498	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	500										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ATACCTCAAGGAAAACAGAAA	0.408000													12	29					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603012	111603012	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111603012G>A	ENST00000431670.2	+	2	499	c.88G>A	c.(88-90)Gat>Aat	p.D30N	PHLDB2_ENST00000393925.3_Missense_Mutation_p.D30N|PHLDB2_ENST00000393923.3_Missense_Mutation_p.D57N|PHLDB2_ENST00000478922.1_Missense_Mutation_p.D30N|PHLDB2_ENST00000481953.1_Missense_Mutation_p.D30N|PHLDB2_ENST00000477695.1_Missense_Mutation_p.D30N|PHLDB2_ENST00000412622.1_Missense_Mutation_p.D30N	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	30						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TGTTGAGAACGATTCCCAAAA	0.418000													68	154					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203676168	203676168	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203676168C>T	ENST00000357681.5	+	9	2254	c.1131C>T	c.(1129-1131)atC>atT	p.I377I	ATP2B4_ENST00000391954.2_Silent_p.I377I|ATP2B4_ENST00000367218.3_Silent_p.I377I|ATP2B4_ENST00000341360.2_Silent_p.I377I|ATP2B4_ENST00000367219.3_Silent_p.I365I	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	377					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CGGTTTTCATCCTGATTCTAT	0.468000													10	32					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102500749	102500749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102500749C>T	ENST00000360184.4	+	56	10878	c.10714C>T	c.(10714-10716)Ctt>Ttt	p.L3572F	DYNC1H1_ENST00000556791.1_3'UTR	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	3572	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TGCTGATGACCTTTGCACAGA	0.502000													17	75					0	0	1	0	0
SMR3B	10879	broad.mit.edu	37	4	71255522	71255522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71255522C>T	ENST00000304915.3	+	3	346	c.197C>T	c.(196-198)cCc>cTc	p.P66L	SMR3B_ENST00000504825.1_Missense_Mutation_p.P66L	NM_006685.3	NP_006676.1			submaxillary gland androgen regulated protein 3B											large_intestine(2)|lung(3)|skin(2)	7		all_hematologic(202;0.196)				CCTCCCGCACCCTATGGTCCA	0.597000													47	117					0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2511789	2511789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2511789C>T	ENST00000569496.1	+	5	706	c.647C>T	c.(646-648)tCc>tTc	p.S216F	C16orf59_ENST00000563531.1_Missense_Mutation_p.S216F|C16orf59_ENST00000361837.4_Missense_Mutation_p.S216F|C16orf59_ENST00000483320.1_Missense_Mutation_p.S49F			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	216										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				AAAGCAGCTTCCCAGAACTCG	0.612000													16	79					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145583638	145583638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145583638C>T	ENST00000532887.1	+	3	1069	c.486C>T	c.(484-486)gcC>gcT	p.A162A	SLC52A2_ENST00000329994.2_Silent_p.A162A|SLC52A2_ENST00000526891.1_3'UTR|SLC52A2_ENST00000402965.1_Silent_p.A162A|SLC52A2_ENST00000527078.1_Silent_p.A162A|SLC52A2_ENST00000540505.1_Silent_p.A74A|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000530047.1_Silent_p.A162A			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	162						integral to plasma membrane	receptor activity|riboflavin transporter activity										GCGTGCTGGCCCTAGTGCAGG	0.652000													47	112					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769170	140769170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140769170C>T	ENST00000519479.1	+	1	1719	c.1719C>T	c.(1717-1719)ttC>ttT	p.F573F	PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1												p.F573F(1)		endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCGCTCTTCGATATGGTGC	0.647000													5	57					0	0	1	0	0
OXTR	5021	broad.mit.edu	37	3	8794856	8794856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:8794856G>A	ENST00000316793.3	-	4	1601	c.977C>T	c.(976-978)cCc>cTc	p.P326L	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	326					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GTAGATCCAGGGGTTGCAGCA	0.597000													11	80					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18624985	18624985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18624985C>T	ENST00000406451.3	+	3	254	c.104C>T	c.(103-105)cCc>cTc	p.P35L	HDAC9_ENST00000417496.2_Missense_Mutation_p.P77L|HDAC9_ENST00000441542.2_Missense_Mutation_p.P35L|HDAC9_ENST00000432645.2_Missense_Mutation_p.P35L|HDAC9_ENST00000401921.1_Missense_Mutation_p.P35L|HDAC9_ENST00000406072.1_Missense_Mutation_p.P63L|HDAC9_ENST00000476135.1_3'UTR|HDAC9_ENST00000428307.2_Missense_Mutation_p.P35L|HDAC9_ENST00000456174.2_Missense_Mutation_p.P4L|HDAC9_ENST00000524023.1_Missense_Mutation_p.P4L|HDAC9_ENST00000405010.3_Missense_Mutation_p.P35L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	35					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	ATGATGATGCCCGTGGTGGAC	0.478000													53	119					0	0	1	0	0
C10orf107	219621	broad.mit.edu	37	10	63519931	63519931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:63519931G>A	ENST00000330194.2	+	5	708	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K		NM_173554.2	NP_775825.1	Q8IVU9	CJ107_HUMAN	chromosome 10 open reading frame 107	135										breast(1)|kidney(1)|lung(4)|prostate(1)|skin(1)	8	Prostate(12;0.016)					ATTGGATACGGAAATGAAGGT	0.383000													18	70					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32050005	32050005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32050005G>A	ENST00000375244.3	-	9	3745	c.3544C>T	c.(3544-3546)Cct>Tct	p.P1182S	TNXB_ENST00000375247.2_Missense_Mutation_p.P1182S			P22105	TENX_HUMAN	tenascin XB	1269	Fibronectin type-III 4.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TGGCCCTCAGGGACAGTCCAG	0.597000													12	43					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129752087	129752087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:129752087G>A	ENST00000446488.3	-	10	1188	c.1085C>T	c.(1084-1086)cCc>cTc	p.P362L	NFRKB_ENST00000524794.1_Missense_Mutation_p.P387L|NFRKB_ENST00000524746.1_Missense_Mutation_p.P362L|NFRKB_ENST00000304521.5_Missense_Mutation_p.P362L	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	362					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GTCTTCAAGGGGCCTAATGAG	0.438000													12	32					0	0	1	0	0
FCRL6	343413	broad.mit.edu	37	1	159778947	159778947	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159778947G>A	ENST00000321935.6	+	5	623	c.537G>A	c.(535-537)gaG>gaA	p.E179E	FCRL6_ENST00000392235.3_Intron|FCRL6_ENST00000339348.5_Silent_p.E172E|FCRL6_ENST00000368106.3_Silent_p.E172E			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	172	Ig-like C2-type 2.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					GAGCCAAGGAGGGAGACTCTG	0.627000													15	57					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439945	150439945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150439945G>A	ENST00000358647.3	+	3	1085	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGCCTGCCAGGAAGACTACAG	0.577000													20	67					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11589616	11589616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11589616G>A	ENST00000294484.6	+	14	2940	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	PTCHD2_ENST00000389575.3_Silent_p.K934K	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	934					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCCACAGGAAGCTGTACTTCG	0.667000													41	85					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57859574	57859574	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57859574C>T	ENST00000228682.2	+	7	719	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S	GLI1_ENST00000543426.1_Missense_Mutation_p.P82S|GLI1_ENST00000546141.1_Missense_Mutation_p.P169S	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	210			P -> A (in a breast cancer sample; somatic mutation).		epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding	p.P210A(1)		NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			GCCCTAGGATCCCCTGTTGGG	0.557000													32	89					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587770	36587770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36587770G>A	ENST00000332987.1	-	7	819	c.397C>T	c.(397-399)Cac>Tac	p.H133Y	APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000352371.1_Missense_Mutation_p.H136Y|APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000404685.3_3'UTR			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	137					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						CAGCCTCTGTGGACCTTTTCA	0.483000													12	74					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171700565	171700565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171700565G>A	ENST00000358196.3	+	7	1199	c.649G>A	c.(649-651)Gaa>Aaa	p.E217K	GAD1_ENST00000429023.1_3'UTR	NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	217					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GTTTACATATGAAATTGCACC	0.358000													18	59					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21901519	21901519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21901519G>A	ENST00000328843.6	+	70	11303	c.11272G>A	c.(11272-11274)Gaa>Aaa	p.E3758K	DNAH11_ENST00000409508.3_Missense_Mutation_p.E3751K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3758					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGACAAGGTGGAAGACATGCA	0.502000									Kartagener syndrome				16	74					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284502	152284502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152284502C>T	ENST00000368799.1	-	3	2895	c.2860G>A	c.(2860-2862)Gga>Aga	p.G954R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	954	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGAATGTCCCTCACTGTCA	0.572000									Ichthyosis				157	376					0	0	1	0	0
IFNLR1	163702	broad.mit.edu	37	1	24483953	24483953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24483953C>T	ENST00000327535.1	-	7	1242	c.1230G>A	c.(1228-1230)aaG>aaA	p.K410K	IFNLR1_ENST00000374421.3_Silent_p.K381K|IFNLR1_ENST00000327575.2_3'UTR	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1																		GGCCTGGCCCCTTCTCAGCCA	0.597000													9	80					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83129338	83129338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:83129338C>T	ENST00000329312.4	+	4	1659	c.1622C>T	c.(1621-1623)tCa>tTa	p.S541L		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	541	8 X approximate tandem repeats.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						ATCAAAGGTTCAGATACTGAA	0.373000													20	13					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186437989	186437989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186437989G>A	ENST00000265023.4	+	2	503	c.291G>A	c.(289-291)aaG>aaA	p.K97K	KNG1_ENST00000287611.2_Silent_p.K97K|KNG1_ENST00000447445.1_Silent_p.K97K|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	97	Cystatin 1.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GTGAGTACAAGGATGCTGCAA	0.453000													23	36					0	0	1	0	0
SLC7A11	23657	broad.mit.edu	37	4	139163150	139163150	+	Missense_Mutation	SNP	G	G	A	rs140307668		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:139163150G>A	ENST00000280612.5	-	1	353	c.74C>T	c.(73-75)cCt>cTt	p.P25L		NM_014331.3	NP_055146.1	Q9UPY5	XCT_HUMAN	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	25					blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)	18	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	GCCCAGGGAAGGCAGCCTCCC	0.507000													20	58					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73635892	73635892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73635892G>A	ENST00000261917.3	-	2	2036	c.1043C>T	c.(1042-1044)tCc>tTc	p.S348F		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	348					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GGGGATGGAGGAAATGAAATC	0.537000													22	62					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41055511	41055511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:41055511C>T	ENST00000324545.7	+	27	4618	c.3985C>T	c.(3985-3987)Cgt>Tgt	p.R1329C	USP9X_ENST00000378308.2_Missense_Mutation_p.R1329C	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1329					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CAGAACTGTTCGTCAGGTGGC	0.398000													52	39					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39645736	39645736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39645736G>A	ENST00000265708.4	-	9	780	c.677C>T	c.(676-678)tCt>tTt	p.S226F	ADAM2_ENST00000347580.4_Missense_Mutation_p.S207F|ADAM2_ENST00000521880.1_Missense_Mutation_p.S226F|ADAM2_ENST00000379853.2_Intron	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	226	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTCCAATGAAGACAGAATAAT	0.259000													32	66					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119962183	119962183	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119962183C>T	ENST00000543831.1	+	3	534	c.285C>T	c.(283-285)tcC>tcT	p.S95S	HSD3B2_ENST00000471656.1_3'UTR|HSD3B2_ENST00000369416.3_Silent_p.S95S	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	95					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	ACAGAGAGTCCATCATGAATG	0.463000													33	62					0	0	1	0	0
SCAMP3	10067	broad.mit.edu	37	1	155227153	155227153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155227153G>A	ENST00000355379.3	-	6	902	c.624C>T	c.(622-624)ttC>ttT	p.F208F	SCAMP3_ENST00000302631.3_Silent_p.F234F|SCAMP3_ENST00000472397.1_5'UTR	NM_052837.2	NP_443069.1	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3	234					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(7)|ovary(4)|urinary_tract(1)	19	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGAAGAAAACGAAGAAATTGA	0.488000													6	22					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41559882	41559882	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41559882G>A	ENST00000400454.1	-	13	3063	c.2586C>T	c.(2584-2586)ttC>ttT	p.F862F		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	862	Ig-like C2-type 9.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGCAGGAAAAGAAACCAGAAT	0.403000													20	55					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167675204	167675204	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167675204C>T	ENST00000519204.1	+	26	7015	c.6897C>T	c.(6895-6897)acC>acT	p.T2299T	TENM2_ENST00000403607.2_Silent_p.T2244T|TENM2_ENST00000545108.1_Silent_p.T2419T|TENM2_ENST00000518659.1_Silent_p.T2420T|TENM2_ENST00000520394.1_Silent_p.T2181T					teneurin transmembrane protein 2																		ACCCCCTGACCAAGCTGGTCC	0.547000													21	83					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70991123	70991123	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70991123G>A	ENST00000357250.6	-	8	1004	c.846C>T	c.(844-846)ccC>ccT	p.P282P	COL9A1_ENST00000370499.4_Silent_p.P39P|COL9A1_ENST00000370496.3_Silent_p.P282P|COL9A1_ENST00000320755.7_Silent_p.P39P	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	282	Triple-helical region (COL3).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GAACTCCAGGGGGGCCCGGAG	0.592000													20	17					0	0	1	0	0
CLASRP	11129	broad.mit.edu	37	19	45572499	45572499	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45572499C>T	ENST00000544944.2	+	16	2502	c.1810C>T	c.(1810-1812)Cgc>Tgc	p.R604C	CLASRP_ENST00000391953.4_Missense_Mutation_p.R561C|CLASRP_ENST00000221455.3_Missense_Mutation_p.R623C			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	623	Arg-rich.				mRNA processing|RNA splicing	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						CCGCAAGATCCGCATGAAGTA	0.667000													11	48					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36122827	36122827	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36122827T>A	ENST00000303965.4	-	23	4357	c.3868A>T	c.(3868-3870)Att>Ttt	p.I1290F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1290	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TAATTATTAATTAGGTCCTCA	0.323000													17	61					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27801932	27801932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27801932G>A	ENST00000408964.2	+	1	2544	c.2493G>A	c.(2491-2493)atG>atA	p.M831I		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	831										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GGAAGCAAATGGAGGAGCTAG	0.438000													38	103					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30963129	30963129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30963129C>T	ENST00000311813.4	+	4	750	c.695C>T	c.(694-696)gCc>gTc	p.A232V	AQP1_ENST00000509504.1_Missense_Mutation_p.A409V|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Missense_Mutation_p.A181V|AQP1_ENST00000409899.1_Missense_Mutation_p.A117V|AQP1_ENST00000441328.2_Missense_Mutation_p.A149V|AQP1_ENST00000434909.2_Missense_Mutation_p.A292V	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				TTCATCCTGGCCCCACGCAGC	0.597000													19	28					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47527654	47527654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47527654C>T	ENST00000273859.3	+	5	1040	c.771C>T	c.(769-771)ggC>ggT	p.G257G	ATP10D_ENST00000504445.1_Silent_p.G257G	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	257					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GATTCCGAGGCTTCCTGTGAG	0.378000													12	49					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882732	228882732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228882732C>T	ENST00000392056.3	-	7	2884	c.2838G>A	c.(2836-2838)gcG>gcA	p.A946A	SPHKAP_ENST00000344657.5_Silent_p.A946A	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	946	PKA-RII subunit binding domain (By similarity).					cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAAGGCAAATCGCTGCAATTT	0.473000													18	129					0	0	1	0	0
C8orf31	286122	broad.mit.edu	37	8	144126132	144126132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144126132G>A	ENST00000395172.1	+	4	605	c.253G>A	c.(253-255)Gac>Aac	p.D85N	C8orf31_ENST00000517653.1_3'UTR	NM_173687.2	NP_775958.1	Q8N9H6	CH031_HUMAN	chromosome 8 open reading frame 31	85										breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GGGAGACACAGACCCCATCCA	0.627000													16	56					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324450	79324450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79324450C>T	ENST00000428286.1	-	8	2863	c.1663G>A	c.(1663-1665)Gaa>Aaa	p.E555K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E914K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	914					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCTACCTTTTCATATACCTTG	0.398000													53	208					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57950064	57950064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57950064C>T	ENST00000564448.1	-	22	2228	c.2168G>A	c.(2167-2169)cGa>cAa	p.R723Q	CNGB1_ENST00000251102.8_Missense_Mutation_p.R729Q			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	729					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GTAGTTATTTCGCATGTCCTT	0.517000													41	93					0	0	1	0	0
SCAF8	22828	broad.mit.edu	37	6	155154119	155154119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155154119C>T	ENST00000367178.3	+	20	3982	c.3406C>T	c.(3406-3408)Cct>Tct	p.P1136S	SCAF8_ENST00000367186.4_Missense_Mutation_p.P1202S|TIAM2_ENST00000461783.3_5'UTR|SCAF8_ENST00000417268.1_Missense_Mutation_p.P1136S	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	1136	Arg-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						TAGAAGTGGTCCTTGGAACCG	0.458000													28	52					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98192614	98192614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98192614C>T	ENST00000357947.3	-	4	695	c.470G>A	c.(469-471)aGg>aAg	p.R157K	TLL2_ENST00000469598.1_Intron	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	157	Metalloprotease (By similarity).				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		AGGCCATATCCTCTCTGTCCT	0.582000													26	77					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21967619	21967619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21967619G>A	ENST00000261200.4	-	33	4060	c.4061C>T	c.(4060-4062)tCg>tTg	p.S1354L	ABCC9_ENST00000261201.4_Missense_Mutation_p.S1354L|ABCC9_ENST00000345162.2_Missense_Mutation_p.S1318L	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1354	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAGAGATAACGATGATTTCCC	0.403000													10	92					0	0	1	0	0
CIB4	130106	broad.mit.edu	37	2	26863423	26863423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26863423G>A	ENST00000288861.4	-	2	120	c.67C>T	c.(67-69)Ctg>Ttg	p.L23L		NM_001029881.1	NP_001025052.1	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	23							calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTCTGGTCAGGAAGGTCAGG	0.567000													32	145					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45799080	45799080	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45799080G>A	ENST00000397928.1	+	8	1660	c.1215_splice	c.e8+1	p.K405_splice	TRPM2_ENST00000397932.2_Splice_Site_p.K405_splice|TRPM2_ENST00000300482.5_Splice_Site_p.K405_splice|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Splice_Site_p.K405_splice	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	405						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GGACCAAAAAGGTGAGGCTGA	0.557000													23	51					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52585170	52585170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52585170C>T	ENST00000591504.1	-	10	1121	c.847G>A	c.(847-849)Gaa>Aaa	p.E283K	CCDC68_ENST00000432185.1_Missense_Mutation_p.E283K|CCDC68_ENST00000337363.4_Missense_Mutation_p.E283K	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	283										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TTAACCTTTTCTCTGAGATTT	0.368000													9	25					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35556516	35556516	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35556516C>T	ENST00000262626.2	+	11	1806	c.981C>T	c.(979-981)ttC>ttT	p.F327F	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Silent_p.F169F|HPN_ENST00000392226.1_Silent_p.F327F	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	327	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GCGCTGACTTCTATGGAAACC	0.602000													38	70					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	50008373	50008373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:50008373G>A	ENST00000451037.2	-	3	1196	c.256C>T	c.(256-258)Cgc>Tgc	p.R86C	CA10_ENST00000570565.1_Missense_Mutation_p.R11C|CA10_ENST00000442502.2_Missense_Mutation_p.R86C|CA10_ENST00000285273.4_Missense_Mutation_p.R86C|CA10_ENST00000340813.6_Missense_Mutation_p.R92C	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	86					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTGTTGATGCGAAGAGGTGTC	0.502000													68	203					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44260327	44260327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44260327G>A	ENST00000315087.7	-	7	1469	c.809C>T	c.(808-810)tCg>tTg	p.S270L	ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000538168.1_Missense_Mutation_p.S306L|ST8SIA5_ENST00000536490.1_Missense_Mutation_p.S239L	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	270					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						AGCTTGCGGCGATTCGAAGTC	0.622000													9	18					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606158	21606158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:21606158C>T	ENST00000281523.2	-	3	702	c.184G>A	c.(184-186)Gct>Act	p.A62T	ZNF385D-AS1_ENST00000412369.1_RNA|ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	62						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						TTTATTACAGCTTTCTGAATC	0.348000													26	66					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87656093	87656093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87656093C>T	ENST00000320005.5	-	10	1111	c.1064G>A	c.(1063-1065)cGa>cAa	p.R355Q		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	355					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						TCCAGTTGTTCGAATAACTCT	0.358000													30	63					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064305	9064305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9064305G>A	ENST00000397910.4	-	3	23344	c.23141C>T	c.(23140-23142)cCc>cTc	p.P7714L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7716	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACAGGAAGGGGAGAGGGGGG	0.537000													29	59					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175306769	175306769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175306769C>T	ENST00000367674.1	-	19	4137	c.3429G>A	c.(3427-3429)atG>atA	p.M1143I	TNR_ENST00000263525.2_Missense_Mutation_p.M1143I	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1143	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TGTCTCCATTCATCAAATGCT	0.507000													18	33					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2408075	2408075	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2408075G>A	ENST00000419816.2	+	1	322	c.48G>A	c.(46-48)gtG>gtA	p.V16V	PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000288766.5_5'UTR|PLCH2_ENST00000378486.3_Silent_p.V16V|PLCH2_ENST00000449969.1_Intron|PLCH2_ENST00000378488.3_Silent_p.V16V			O75038	PLCH2_HUMAN	phospholipase C, eta 2	16	Necessary for plasma membrane localization (By similarity).				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		AGGGAACGGTGGCCTGGCTGG	0.687000													7	10					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129691083	129691083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129691083G>A	ENST00000358303.4	-	1	208	c.124C>T	c.(124-126)Ccg>Tcg	p.P42S	ZC3HC1_ENST00000360708.5_Missense_Mutation_p.P42S|ZC3HC1_ENST00000481503.1_Missense_Mutation_p.P42S|ZC3HC1_ENST00000311873.5_Silent_p.P5P	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	42					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					CCCTCTTCCGGGGCAATCCCC	0.597000													42	84					0	0	1	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23444016	23444016	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23444016G>A	ENST00000526079.1	+	0	1660					NR_027407.1|NR_033350.1																						GGACACGGAGGAGAACATCTG	0.617000													10	65					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79579213	79579213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:79579213G>A	ENST00000372391.2	-	17	3542	c.3537C>T	c.(3535-3537)ccC>ccT	p.P1179P	DLG5_ENST00000372388.2_Silent_p.P839P|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1179					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TCAAACTCCGGGGAACAGTGC	0.612000													5	38					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116335236	116335236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116335236C>T	ENST00000369252.4	-	3	623	c.322G>A	c.(322-324)Gaa>Aaa	p.E108K	ABLIM1_ENST00000277895.5_Missense_Mutation_p.E168K|ABLIM1_ENST00000533213.2_Missense_Mutation_p.E108K	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	168	LIM zinc-binding 1.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding	p.E108K(1)		breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		GTCACCACTTCGCCCTCCACG	0.537000													27	82					0	0	1	0	0
NR2C1	7181	broad.mit.edu	37	12	95419008	95419008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95419008C>T	ENST00000333003.5	-	13	1885	c.1555G>A	c.(1555-1557)Gaa>Aaa	p.E519K		NM_003297.3	NP_003288.2	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	519					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)	13						TCTATCTGTTCCATGTTTTCT	0.343000													10	33					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101797320	101797320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101797320C>T	ENST00000375001.3	+	18	2527	c.2104C>T	c.(2104-2106)Cct>Tct	p.P702S		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	702	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CAGAGGCTTACCTGGACCCCC	0.612000													14	77					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66460536	66460536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:66460536C>T	ENST00000404260.3	+	29	5846	c.5538C>T	c.(5536-5538)ctC>ctT	p.L1846L	MAST4_ENST00000405643.1_Silent_p.L1664L|MAST4_ENST00000403666.1_Silent_p.L1654L|MAST4_ENST00000261569.7_Silent_p.L1649L|MAST4_ENST00000403625.2_Silent_p.L1843L			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1846						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CACCAGTTCTCCCCAGCAGCA	0.557000													21	53					0	0	1	0	0
CXCR4	7852	broad.mit.edu	37	2	136872763	136872763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136872763G>A	ENST00000409817.1	-	1	1050	c.747C>T	c.(745-747)atC>atT	p.I249I	CXCR4_ENST00000241393.3_Silent_p.I245I|CXCR4_ENST00000466288.1_5'UTR	NM_001008540.1	NP_001008540.1	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4	245					activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	AGAAAGCCAGGATGAGGATGA	0.502000													19	111					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51330320	51330320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51330320C>T	ENST00000326856.4	-	4	421	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	KLK15_ENST00000416184.1_Missense_Mutation_p.E99K|KLK15_ENST00000596931.1_Missense_Mutation_p.E98K|KLK15_ENST00000598239.1_Missense_Mutation_p.E99K|KLK15_ENST00000301421.2_Missense_Mutation_p.E99K	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	99	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CTGCGCGCTTCGTAGCGCGGG	0.667000													21	73					0	0	1	0	0
OR5V1	81696	broad.mit.edu	37	6	29323781	29323781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29323781C>T	ENST00000377154.1	-	4	491	c.192G>A	c.(190-192)ggG>ggA	p.G64G	OR5V1_ENST00000543825.1_Silent_p.G64G			Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V, member 1	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(3)|large_intestine(3)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AGGCCAAGTTCCCTAGAAAAT	0.408000													58	126					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73128174	73128174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:73128174G>A	ENST00000545377.1	+	10	1212	c.1036G>A	c.(1036-1038)Gat>Aat	p.D346N	ARHGEF28_ENST00000426542.2_Missense_Mutation_p.D346N|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.D346N|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.D346N|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.D346N|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.D33N|ARHGEF28_ENST00000296794.6_Missense_Mutation_p.D346N	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		TCGCTCCTTCGATATCCTAAA	0.423000													5	24					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173542416	173542416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173542416G>A	ENST00000367714.3	-	9	1373	c.951C>T	c.(949-951)ttC>ttT	p.F317F	SLC9C2_ENST00000536496.1_Silent_p.F215F|RP3-436N22.3_ENST00000431459.1_RNA|SLC9C2_ENST00000466087.1_5'UTR	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	317					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										CAATGCCAAAGAAAGCATATA	0.284000													22	41					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109762861	109762861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:109762861G>A	ENST00000399132.1	-	31	2176	c.1646C>T	c.(1645-1647)cCt>cTt	p.P549L	COL25A1_ENST00000399127.1_Missense_Mutation_p.P522L|COL25A1_ENST00000399126.1_Missense_Mutation_p.P549L	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	549						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTTTGGTCCAGGAAGTCCATG	0.363000													20	36					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551337	35551337	+	Missense_Mutation	SNP	C	C	T	rs147075058	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35551337C>T	ENST00000262626.2	+	8	1366	c.541C>T	c.(541-543)Cgc>Tgc	p.R181C	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Intron|HPN_ENST00000392226.1_Missense_Mutation_p.R181C	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	181	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	AGTCAGCCTTCGCTATGATGG	0.682000													52	91					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176295654	176295654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176295654C>T	ENST00000329542.4	+	4	803	c.529C>T	c.(529-531)Cct>Tct	p.P177S	UNC5A_ENST00000261961.3_Missense_Mutation_p.P137S	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	177	Ig-like C2-type.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAGGGCATCCCTCCAGCCGA	0.667000													3	6					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186022189	186022189	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186022189T>A	ENST00000271588.4	+	43	6912	c.6683T>A	c.(6682-6684)cTc>cAc	p.L2228H	HMCN1_ENST00000367492.2_Missense_Mutation_p.L2228H	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2228	Ig-like C2-type 20.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCCCCAAATCTCATCTGGAAG	0.318000													48	75					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47514787	47514787	+	Missense_Mutation	SNP	G	G	A	rs149671949		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47514787G>A	ENST00000273859.3	+	2	499	c.230G>A	c.(229-231)cGa>cAa	p.R77Q	ATP10D_ENST00000504445.1_Missense_Mutation_p.R77Q	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	77					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						AATCGAATACGAACAACAAAG	0.388000													23	47					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130187704	130187704	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130187704C>T	ENST00000265379.6	+	38	7350	c.6856C>T	c.(6856-6858)Caa>Taa	p.Q2286*	COL6A5_ENST00000432398.2_Nonsense_Mutation_p.Q2286*			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2286	Nonhelical region.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						TGTCTCTCTTCAAGAATATTA	0.363000													10	23					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129498871	129498871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:129498871C>T	ENST00000421865.2	+	10	1376	c.1327C>T	c.(1327-1329)Cat>Tat	p.H443Y		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	443	Laminin EGF-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGGATCCTGTCATTGCAAAAC	0.443000													18	34					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35010173	35010173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35010173C>T	ENST00000231420.6	-	12	1470	c.1270G>A	c.(1270-1272)Gaa>Aaa	p.E424K		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	424					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	ATTTCAAATTCATCCCGCAGC	0.438000													49	100					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81381519	81381519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:81381519C>T	ENST00000222390.5	-	5	768	c.542G>A	c.(541-543)cGa>cAa	p.R181Q	HGF_ENST00000457544.2_Missense_Mutation_p.R176Q|HGF_ENST00000453411.1_Missense_Mutation_p.R176Q|HGF_ENST00000444829.2_Missense_Mutation_p.R181Q|HGF_ENST00000423064.2_Missense_Mutation_p.R181Q	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	181	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						TTCTTCCCCTCGAGGATTTCG	0.433000													20	93					0	0	1	0	0
FAM117B	150864	broad.mit.edu	37	2	203621974	203621974	+	Silent	SNP	C	C	T	rs140222767		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:203621974C>T	ENST00000303116.6	+	6	1153	c.411C>T	c.(409-411)ccC>ccT	p.P137P	FAM117B_ENST00000392238.2_Silent_p.P381P	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	381	Poly-Pro.									breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						CTCCACCCCCCCTTGTACAGA	0.493000													18	45					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127623022	127623022	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127623022C>T	ENST00000508053.1	-	60	7832	c.6858G>A	c.(6856-6858)agG>agA	p.R2286R	FBN2_ENST00000262464.4_Silent_p.R2286R			P35556	FBN2_HUMAN	fibrillin 2	2286	EGF-like 38; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTTGATCTTCCCTGAGGGCAT	0.453000													42	132					0	0	1	0	0
LOXL1	4016	broad.mit.edu	37	15	74238812	74238812	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74238812C>T	ENST00000261921.7	+	3	1592	c.1266C>T	c.(1264-1266)ttC>ttT	p.F422F		NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	422	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						TACTGCGCTTCCCCCAGCGCG	0.677000													9	46					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68910518	68910518	+	Silent	SNP	G	G	A	rs62642583		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:68910518G>A	ENST00000262340.5	-	4	347	c.294C>T	c.(292-294)atC>atT	p.I98I		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	98					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						CTGTTATGACGATCCTTTTCT	0.423000													23	53					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33591242	33591242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33591242C>T	ENST00000380099.3	+	1	672	c.664C>T	c.(664-666)Ctc>Ttc	p.L222F	KL_ENST00000426690.2_Intron|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	222	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTACGCGGAGCTCTGCTTCCG	0.692000													4	32					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34174758	34174758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34174758C>T	ENST00000373381.4	-	22	3683	c.3507G>A	c.(3505-3507)caG>caA	p.Q1169Q	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Silent_p.Q42Q	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1129	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTGGCTGGGTCTGGATGGAGT	0.473000													31	81					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48353039	48353039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:48353039C>T	ENST00000297423.4	+	8	1416	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F	SPIDR_ENST00000518074.1_Silent_p.F284F|SPIDR_ENST00000541342.1_Silent_p.F274F|SPIDR_ENST00000521214.1_3'UTR	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		AAGTTCTCTTCACCAAGGAGA	0.587000													23	56					0	0	1	0	0
IL12B	3593	broad.mit.edu	37	5	158750330	158750330	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:158750330G>A	ENST00000231228.2	-	3	551	c.96C>T	c.(94-96)gtC>gtT	p.V32V		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	32	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAATTCTACGACATAAACTG	0.498000													15	37					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045373	142045373	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142045373G>A	ENST00000390392.3	+	0	122																											ATGGGCTGCAGGCTGCTCTGC	0.567000													20	163					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107078653	107078653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107078653C>T	ENST00000229387.5	+	1	180	c.62C>T	c.(61-63)tCg>tTg	p.S21L	RFX4_ENST00000392842.1_Intron|RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000357881.4_Intron	NM_032491.5	NP_115880.2	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	369					transcription, DNA-dependent	nucleus	DNA binding	p.S21L(1)		NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						cagatagattcgagatgccca	0.478000													8	4					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141459834	141459834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141459834G>A	ENST00000389484.3	-	39	7149	c.6178C>T	c.(6178-6180)Cgc>Tgc	p.R2060C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2060					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGTCTGTGCGAGCATCACAC	0.373000										TSP Lung(27;0.18)			13	166					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166900351	166900351	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166900351T>A	ENST00000423058.2	-	11	1888	c.1871A>T	c.(1870-1872)cAg>cTg	p.Q624L	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.Q624L|SCN1A_ENST00000303395.4_Missense_Mutation_p.Q624L|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.Q624L	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	624						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCTACTGGTCTGACTCAGGTT	0.537000													19	70					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153585856	153585856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153585856G>A	ENST00000422373.1	-	29	5139	c.4891C>T	c.(4891-4893)Ccg>Tcg	p.P1631S	FLNA_ENST00000369856.3_5'UTR|FLNA_ENST00000360319.4_Missense_Mutation_p.P1631S|FLNA_ENST00000344736.4_Missense_Mutation_p.P1631S|FLNA_ENST00000369850.3_Missense_Mutation_p.P1631S	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1631					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACGCGGTACGGGGAGAAGGGG	0.652000													14	12					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7334968	7334968	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7334968C>T	ENST00000318881.6	+	3	1077	c.840C>T	c.(838-840)acC>acT	p.T280T	SYT9_ENST00000396716.2_Silent_p.T248T	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	280	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		ACAGAAAGACCCTGAACCCTG	0.438000													27	278					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36301496	36301496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36301496C>T	ENST00000296604.3	-	1	508	c.23G>A	c.(22-24)gGc>gAc	p.G8D	RANBP3L_ENST00000502994.1_Missense_Mutation_p.G8D|RANBP3L_ENST00000515759.1_Missense_Mutation_p.G8D	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	8					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GTGGCTGCTGCCTTTTCTTGG	0.542000													24	111					0	0	1	0	0
ZNF527	84503	broad.mit.edu	37	19	37879797	37879797	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37879797C>T	ENST00000436120.2	+	5	953	c.846C>T	c.(844-846)gcC>gcT	p.A282A	ZNF527_ENST00000587349.1_Intron	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTGGTGATGCCTTTAGCTGTT	0.383000													45	134					0	0	1	0	0
PPA2	27068	broad.mit.edu	37	4	106345444	106345444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:106345444G>A	ENST00000341695.5	-	7	594	c.564C>T	c.(562-564)atC>atT	p.I188I	PPA2_ENST00000432483.2_Silent_p.I86I|PPA2_ENST00000348706.5_Silent_p.I159I|PPA2_ENST00000354147.3_Intron|PPA2_ENST00000509426.1_5'UTR|PPA2_ENST00000380004.2_Silent_p.I170I|PPA2_ENST00000310267.7_Silent_p.I109I|PPA2_ENST00000357415.4_Silent_p.I203I	NM_176869.2	NP_789845.1	Q9H2U2	IPYR2_HUMAN	pyrophosphatase (inorganic) 2	188					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	11		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)		AAATTCCAAGGATCTTCACAT	0.338000													35	83					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31590856	31590856	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31590856C>T	ENST00000379416.3	-	20	2216	c.2168G>A	c.(2167-2169)gGg>gAg	p.G723E		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	723					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TTCGGAAAACCCCTTCTTTAG	0.448000													48	159					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231150513	231150513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231150513G>A	ENST00000392045.3	+	17	1725	c.1611G>A	c.(1609-1611)gcG>gcA	p.A537A	SP140_ENST00000417495.3_Silent_p.A423A|SP140_ENST00000343805.6_Silent_p.A477A|SP140_ENST00000486687.2_Silent_p.A461A|SP140_ENST00000350136.5_Silent_p.A406A|SP140_ENST00000420434.3_Silent_p.A510A	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	537					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AAAAGAAGGCGAACGTGAATC	0.443000													17	179					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58084602	58084602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58084602C>T	ENST00000357272.4	+	8	1477	c.1312C>T	c.(1312-1314)Cct>Tct	p.P438S	FLNB_ENST00000358537.3_Missense_Mutation_p.P438S|FLNB_ENST00000295956.4_Missense_Mutation_p.P438S|FLNB_ENST00000429972.2_Missense_Mutation_p.P438S|FLNB_ENST00000490882.1_Missense_Mutation_p.P438S|FLNB_ENST00000348383.5_Missense_Mutation_p.P438S|FLNB_ENST00000419752.2_Missense_Mutation_p.P269S|FLNB_ENST00000493452.1_Missense_Mutation_p.P269S			O75369	FLNB_HUMAN	filamin B, beta	438					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGACACTATTCCTAAGAGTCC	0.552000													25	94					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3679990	3679990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3679990C>T	ENST00000344754.4	-	7	1644	c.1645G>A	c.(1645-1647)Gga>Aga	p.G549R	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.G549R	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	549	Ig-like C2-type 5.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						AGCAGGGCTCCATTCAGGTAC	0.687000													5	16					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129198739	129198739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129198739C>T	ENST00000296266.3	+	14	1807	c.1615C>T	c.(1615-1617)Ctc>Ttc	p.L539F	IFT122_ENST00000347300.2_Missense_Mutation_p.L429F|IFT122_ENST00000431818.2_Missense_Mutation_p.L338F|IFT122_ENST00000349441.2_Missense_Mutation_p.L377F|IFT122_ENST00000440957.2_Missense_Mutation_p.L279F|IFT122_ENST00000348417.2_Missense_Mutation_p.L488F|IFT122_ENST00000507564.1_Missense_Mutation_p.L480F|IFT122_ENST00000504021.1_Missense_Mutation_p.L382F	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	488					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						AAGAGAAGGCCTCTTAGTGGG	0.562000													27	60					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113815359	113815359	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113815359C>T	ENST00000260191.2	+	8	1229	c.972C>T	c.(970-972)gtC>gtT	p.V324V	HTR3B_ENST00000537778.1_Silent_p.V313V	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	324					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TCGTGTTGGTCAAATTCCTCC	0.562000													10	83					0	0	1	0	0
CLLU1OS	574016	broad.mit.edu	37	12	92814813	92814813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:92814813C>T	ENST00000378487.2	-	3	280	c.279G>A	c.(277-279)ggG>ggA	p.G93G	CLLU1OS_ENST00000538965.1_Silent_p.G93G	NM_001025232.1	NP_001020403.1	Q5K130	CLU1O_HUMAN	chronic lymphocytic leukemia up-regulated 1 opposite strand	93										large_intestine(1)|lung(7)	8						CTTCCTTCTTCCCATCATCAT	0.428000													79	347					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1743171	1743171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1743171G>A	ENST00000381241.3	+	3	453	c.254G>A	c.(253-255)cGa>cAa	p.R85Q	ASMT_ENST00000381233.3_Missense_Mutation_p.R85Q|ASMT_ENST00000381229.4_Missense_Mutation_p.R85Q	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	85					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCTTTCTATCGAAACACAGAG	0.547000													76	194					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165179979	165179979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165179979C>T	ENST00000342310.3	-	6	1086	c.704G>A	c.(703-705)aGt>aAt	p.S235N	RP11-38C18.2_ENST00000457106.1_RNA|LMX1A_ENST00000367893.4_Missense_Mutation_p.S235N|LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Missense_Mutation_p.S235N	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	235						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					GACACGGACACTCAGCCCTGT	0.483000													7	44					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41450713	41450713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41450713G>A	ENST00000400454.1	-	26	5089	c.4612C>T	c.(4612-4614)Ctg>Ttg	p.L1538L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1538	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCTTCCTGCAGGTCATACAGG	0.577000													14	37					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7173261	7173261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7173261C>T	ENST00000406697.1	+	10	1486	c.858C>T	c.(856-858)cgC>cgT	p.R286R	C1S_ENST00000328916.3_Silent_p.R286R|C1S_ENST00000402681.3_Silent_p.R119R|C1S_ENST00000360817.5_Silent_p.R286R			P09871	C1S_HUMAN	complement component 1, s subcomponent	286	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GGAAACTTCGCTATCATGGAG	0.433000													6	78					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38229537	38229537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38229537G>A	ENST00000339503.4	-	8	2181	c.1680C>T	c.(1678-1680)gcC>gcT	p.A560A	ZNF573_ENST00000536220.1_Silent_p.A530A|ZNF573_ENST00000392138.1_Silent_p.A531A|ZNF573_ENST00000357309.3_Silent_p.A530A|ZNF573_ENST00000590414.2_Silent_p.A618A	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			CACGACTGAAGGCCTTCCCAC	0.403000													22	102					0	0	1	0	0
ZDHHC1	29800	broad.mit.edu	37	16	67429105	67429105	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67429105G>A	ENST00000348579.2	-	10	1371	c.1030C>T	c.(1030-1032)Ccg>Tcg	p.P344S	ZDHHC1_ENST00000566075.1_5'UTR	NM_013304.2	NP_037436.1	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	344						integral to membrane	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|urinary_tract(1)	10		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		GTCGGATCCGGGGAGGCAGGG	0.637000													10	13					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126208199	126208199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126208199C>T	ENST00000290868.2	-	17	1681	c.1628G>A	c.(1627-1629)cGa>cAa	p.R543Q	UROC1_ENST00000383579.3_Missense_Mutation_p.R603Q	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	543					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		ATGGTGATCTCGGCTCAGGAC	0.577000													21	100					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50155850	50155850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50155850C>T	ENST00000347869.3	+	25	2584	c.2409C>T	c.(2407-2409)gtC>gtT	p.V803V	RP11-493K19.3_ENST00000437204.1_RNA|RP11-493K19.3_ENST00000425674.1_RNA	NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	803	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AAGATGCTGTCCGGAAAGCCA	0.542000													6	41					0	0	1	0	0
CCT5	22948	broad.mit.edu	37	5	10261701	10261701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:10261701C>T	ENST00000280326.4	+	8	1443	c.1023C>T	c.(1021-1023)atC>atT	p.I341I	CCT5_ENST00000515676.1_Silent_p.I303I|CCT5_ENST00000506600.1_Silent_p.I248I|CCT5_ENST00000515390.1_Silent_p.I286I|CCT5_ENST00000503026.1_Silent_p.I320I	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	341					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						GAGGGCGGATCGTCCCCAGGT	0.502000													95	296					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27745364	27745364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27745364G>A	ENST00000264717.2	+	18	1673	c.1610G>A	c.(1609-1611)aGc>aAc	p.S537N	GCKR_ENST00000424318.2_Missense_Mutation_p.S347N	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	537					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					TGCATCGAGAGCCTCCTCCGA	0.527000													23	85					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96239829	96239829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:96239829C>T	ENST00000347108.3	-	18	2614	c.2182G>A	c.(2182-2184)Gaa>Aaa	p.E728K	DZIP1_ENST00000361396.2_Missense_Mutation_p.E709K|DZIP1_ENST00000376829.2_Missense_Mutation_p.E728K|DZIP1_ENST00000361156.3_Missense_Mutation_p.E709K			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	728					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TCCTCGATTTCGCTTCCCTCG	0.547000													39	98					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4945091	4945091	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4945091G>A	ENST00000321961.2	-	1	546	c.479C>T	c.(478-480)cCc>cTc	p.P160L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAATGGCAAGGGGAGGATGAG	0.542000													19	46					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37433933	37433933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37433933C>T	ENST00000374660.1	+	8	1335	c.1236C>T	c.(1234-1236)ttC>ttT	p.F412F	ANKRD30A_ENST00000602533.1_Silent_p.F412F|ANKRD30A_ENST00000361713.1_Silent_p.F412F			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	468						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATCAGAGGTTCCCATCAGAAT	0.254000													45	89					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17104307	17104307	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17104307G>A	ENST00000443236.1	-	12	1357	c.1326C>T	c.(1324-1326)acC>acT	p.T442T	CPAMD8_ENST00000388925.4_Silent_p.T395T	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	395						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CAACTTCACTGGTGTAGATGT	0.577000													12	46					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54893190	54893190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54893190G>A	ENST00000293373.6	+	2	233	c.154G>A	c.(154-156)Gaa>Aaa	p.E52K	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.E2K	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	52					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						AAAGTCCATGGAACCATCTCT	0.418000													42	91					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54802530	54802530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54802530G>A	ENST00000391745.1	-	9	1278	c.962C>T	c.(961-963)tCc>tTc	p.S321F	LILRA3_ENST00000391744.3_Missense_Mutation_p.S240F|LILRA3_ENST00000251390.3_Missense_Mutation_p.S304F					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCACTCGGAGGAGAGGTTGTA	0.677000													27	74					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69699681	69699681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:69699681G>A	ENST00000337103.4	+	11	2718	c.1126G>A	c.(1126-1128)Gaa>Aaa	p.E376K	C8orf34_ENST00000539993.1_Missense_Mutation_p.E401K|C8orf34_ENST00000325233.3_Missense_Mutation_p.E145K|C8orf34_ENST00000518698.1_Missense_Mutation_p.E487K			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	401					signal transduction		cAMP-dependent protein kinase regulator activity	p.E376K(1)		NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TTTGCAGGATGAATCCTTAAA	0.358000													6	25					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58606038	58606038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:58606038G>A	ENST00000267485.7	-	2	233	c.39C>T	c.(37-39)ttC>ttT	p.F13F	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	13						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						GAAGGCTACAGAAAGCCAGAC	0.473000													39	68					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33603471	33603471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33603471C>T	ENST00000170564.2	+	13	2158	c.1844C>T	c.(1843-1845)cCt>cTt	p.P615L		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	615						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					GAGTGGCACCCTGACAAGCTT	0.413000													28	58					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103143606	103143606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103143606G>A	ENST00000428762.1	-	52	8505	c.8346C>T	c.(8344-8346)ttC>ttT	p.F2782F	CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000343529.5_Silent_p.F2782F|RELN_ENST00000424685.2_Silent_p.F2782F	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2782					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.F2782L(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AACTCACACCGAAGTCAGTAG	0.408000													35	73					0	0	1	0	0
FAM83H	286077	broad.mit.edu	37	8	144810193	144810193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144810193G>A	ENST00000388913.3	-	5	1563	c.1438C>T	c.(1438-1440)Cgc>Tgc	p.R480C		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	480					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAACCCGCGCGGCCCCCGCGA	0.721000													5	8					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32476018	32476018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:32476018G>A	ENST00000404025.2	-	5	1403	c.915C>T	c.(913-915)gcC>gcT	p.A305A	NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Silent_p.A305A|NLRC4_ENST00000360906.5_Silent_p.A305A			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	305	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TGAGAGCCTGGGCGCTGTCTT	0.532000													34	77					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120539917	120539917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120539917G>A	ENST00000256646.2	-	4	673	c.454C>T	c.(454-456)Ccc>Tcc	p.P152S	NOTCH2_ENST00000602566.1_Missense_Mutation_p.P113S	NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	152	EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTGCACAGGGATGAGACAGG	0.498000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				33	131					0	0	1	0	0
IL36G	56300	broad.mit.edu	37	2	113736250	113736250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113736250G>A	ENST00000259205.4	+	2	104	c.35G>A	c.(34-36)gGa>gAa	p.G12E	IL36G_ENST00000376489.2_Missense_Mutation_p.G12E	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	12					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						GATGGTGGAGGAAGGGCCGTC	0.527000													23	52					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29886152	29886152	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29886152G>A	ENST00000310624.6	+	4	2556	c.2523G>A	c.(2521-2523)aaG>aaA	p.K841K		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	847	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						CCCCAAAGAAGGCAGAGGAAG	0.547000													4	28					0	0	1	0	0
ABHD14B	84836	broad.mit.edu	37	3	52003882	52003882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52003882C>T	ENST00000461108.1	-	3	614	c.530G>A	c.(529-531)gGg>gAg	p.G177E	ABHD14B_ENST00000395008.2_Intron|ABHD14B_ENST00000525795.1_Intron|ABHD14B_ENST00000487005.1_Intron|ABHD14B_ENST00000315877.10_Intron|RP11-155D18.12_ENST00000488257.1_RNA|ABHD14B_ENST00000361143.5_Intron|ABHD14B_ENST00000483233.1_Intron			Q96IU4	ABHEB_HUMAN	abhydrolase domain containing 14B	0						cytoplasm|nucleus	hydrolase activity			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000548)|KIRC - Kidney renal clear cell carcinoma(197;0.00072)		ATTATCCAGCCCCCAGATGAG	0.567000													7	38					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122759917	122759917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:122759917G>A	ENST00000245838.8	-	25	2934	c.2903C>T	c.(2902-2904)tCt>tTt	p.S968F	THOC2_ENST00000491737.1_Missense_Mutation_p.S853F|THOC2_ENST00000355725.4_Missense_Mutation_p.S968F	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	968					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						ATTTTTGGTAGATTCTAAAAA	0.333000													12	10					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139727966	139727966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139727966C>T	ENST00000303045.6	-	30	2922	c.2476G>A	c.(2476-2478)Gaa>Aaa	p.E826K	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Missense_Mutation_p.E826K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	826	Collagen-like 6.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AGTCCCAGTTCACCTTTTTCT	0.388000										HNSCC(7;0.00092)			29	107					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8234487	8234487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8234487G>A	ENST00000520004.1	-	3	1696	c.1432C>T	c.(1432-1434)Cac>Tac	p.H478Y	SGK223_ENST00000330777.4_Missense_Mutation_p.H478Y			Q86YV5	SG223_HUMAN		478							ATP binding|non-membrane spanning protein tyrosine kinase activity										TCTTCCGGGTGGGCCGCCATG	0.647000													7	32					0	0	1	0	0
RNF219	79596	broad.mit.edu	37	13	79190701	79190701	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:79190701G>A	ENST00000282003.6	-	6	1253	c.1195C>T	c.(1195-1197)Cag>Tag	p.Q399*	RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000560584.2_RNA	NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	399							zinc ion binding	p.Q399E(1)		breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GTACTGAGCTGAAGGCAACTA	0.423000													43	132					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109155434	109155434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:109155434G>A	ENST00000261483.4	+	14	3226	c.2174G>A	c.(2173-2175)aGt>aAt	p.S725N		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	725					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		GAATCAGCAAGTTCAAATTCA	0.308000													25	131					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128341841	128341841	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128341841G>A	ENST00000389524.4	+	13	1541	c.1488G>A	c.(1486-1488)ctG>ctA	p.L496L	MYO7B_ENST00000428314.1_Silent_p.L496L|MYO7B_ENST00000409816.2_Silent_p.L496L			Q6PIF6	MYO7B_HUMAN	myosin VIIB	496	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGCCCACCCTGGACCTGCTGG	0.587000													16	60					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38793807	38793807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38793807G>A	ENST00000449082.2	-	11	1657	c.1658C>T	c.(1657-1659)cCt>cTt	p.P553L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	553					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTGAGGAAGAGGGCTTCTAGG	0.612000													37	71					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748223	143748223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143748223C>T	ENST00000408906.2	+	1	763	c.729C>T	c.(727-729)tcC>tcT	p.S243S		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CCTGCTCCTCCCACCTTTGCA	0.617000													14	179					0	0	1	0	0
TRAM1	23471	broad.mit.edu	37	8	71499399	71499399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:71499399G>A	ENST00000521425.1	-	7	1361	c.325C>T	c.(325-327)Cgt>Tgt	p.R109C	TRAM1_ENST00000521049.1_5'UTR|TRAM1_ENST00000262213.2_Missense_Mutation_p.R195C|TRAM1_ENST00000536748.1_Missense_Mutation_p.R164C			Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	195					cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	17			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			ACAAGCTGACGAGGAATATCT	0.398000													20	54					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917308	48917308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48917308C>T	ENST00000311378.4	+	2	1187	c.659C>T	c.(658-660)tCg>tTg	p.S220L	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.S127L	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	220	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GTGCACCAGTCGGTCACCATG	0.637000													14	48					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106843718	106843718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:106843718C>T	ENST00000276185.4	+	16	2548	c.2548C>T	c.(2548-2550)Cgg>Tgg	p.R850W				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	850						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						CCTGCCCTTCCGGATCCAGAG	0.612000													25	15					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66189691	66189691	+	Silent	SNP	G	G	A	rs147825645	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66189691G>A	ENST00000311034.2	+	2	452	c.276G>A	c.(274-276)ggG>ggA	p.G92G		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	92	PAS 1.				transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CAGCCGAGGGGAAATTGCTCT	0.602000													29	80					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74285296	74285296	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74285296C>T	ENST00000295897.4	+	13	1814	c.1725C>T	c.(1723-1725)ttC>ttT	p.F575F	ALB_ENST00000503124.1_Silent_p.F425F|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000509063.1_Silent_p.F575F|ALB_ENST00000415165.2_Silent_p.F383F|ALB_ENST00000401494.3_Silent_p.F460F	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	575	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TGGATGATTTCGCAGCTTTTG	0.413000													29	75					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119097170	119097170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119097170C>T	ENST00000328252.3	+	13	3797	c.3428C>T	c.(3427-3429)cCc>cTc	p.P1143L	PAPPA_ENST00000534838.1_Missense_Mutation_p.P181L	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1143					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						AGGAACAATCCCCTGATTATC	0.632000													12	52					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2153339	2153339	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2153339C>A	ENST00000262304.4	-	23	8927	c.8719G>T	c.(8719-8721)Gct>Tct	p.A2907S	PKD1_ENST00000423118.1_Missense_Mutation_p.A2907S	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	2907					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GTGACCACAGCACCGACGGAG	0.692000													15	91					1.2644e-06	1.26745e-06	1	1	0
MYO16	23026	broad.mit.edu	37	13	109817360	109817360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109817360C>T	ENST00000356711.2	+	33	5336	c.5210C>T	c.(5209-5211)tCa>tTa	p.S1737L	MYO16-AS1_ENST00000439299.1_RNA|MYO16_ENST00000357550.2_Missense_Mutation_p.S1737L	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1737					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTATCTAATTCACTATCTAGT	0.348000													14	32					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118779085	118779085	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118779085G>A	ENST00000334801.3	-	2	1270	c.306C>T	c.(304-306)ccC>ccT	p.P102P	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	102					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		AGCTGAAAGGGGGCACCCCTG	0.637000													32	79					0	0	1	0	0
XCR1	2829	broad.mit.edu	37	3	46062951	46062951	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46062951G>A	ENST00000309285.3	-	2	845	c.489C>T	c.(487-489)ctC>ctT	p.L163L	XCR1_ENST00000542109.1_Silent_p.L163L	NM_001024644.1	NP_001019815.1	P46094	XCR1_HUMAN	chemokine (C motif) receptor 1	163					chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		AGATGGTGTCGAGGATGGAGG	0.602000													10	19					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23235899	23235899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23235899C>T	ENST00000285848.5	+	1	169	c.169C>T	c.(169-171)Ctt>Ttt	p.L57F	OXA1L_ENST00000604262.1_5'UTR	NM_005015.3	NP_005006.3	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	0					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		AGCAAGTCCTCTTCCGGGCAA	0.607000													57	128					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37584296	37584296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37584296C>T	ENST00000399151.3	+	7	890	c.805C>T	c.(805-807)Ctc>Ttc	p.L269F	DOPEY2_ENST00000492760.1_3'UTR	NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	269					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						AGCCATCCCCCTCCTCAGATC	0.502000													25	85					0	0	1	0	0
FGF21	26291	broad.mit.edu	37	19	49261309	49261309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49261309G>A	ENST00000593756.1	+	4	1034	c.462G>A	c.(460-462)cgG>cgA	p.R154R	FGF21_ENST00000222157.3_Silent_p.R154R			Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21	154					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)|cervix(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		CCCCACACCGGGACCCTGCAC	0.682000													36	56					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31915571	31915571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31915571C>T	ENST00000456570.1	+	17	2272	c.2217C>T	c.(2215-2217)tcC>tcT	p.S739S	CFB_ENST00000425368.2_Silent_p.S237S|CFB_ENST00000477310.1_Silent_p.S588S|CFB_ENST00000556679.1_Silent_p.S739S			P00751	CFAB_HUMAN	complement factor B	237	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TCCTGTCTTCCCTGACAGAGA	0.547000													87	184					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31127291	31127291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31127291C>T	ENST00000304166.4	+	12	1224	c.935C>T	c.(934-936)cCt>cTt	p.P312L	ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.P312L|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.P312L|ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.P291L	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	312					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity	p.P312N(1)		endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						ATCAAAGGCCCTGTGGTTGGC	0.517000													24	64					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147540	26147540	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:26147540C>T	ENST00000331351.5	+	2	1734	c.1342C>T	c.(1342-1344)Cag>Tag	p.Q448*		NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	448					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		TCAAGATTTTCAGTGGGAACA	0.468000													5	14					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190195323	190195323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190195323G>A	ENST00000367462.3	-	6	1081	c.850C>T	c.(850-852)Ccc>Tcc	p.P284S	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.P182S	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		284						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGAAATTTGGGACCACAGTGA	0.438000													20	61					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33505192	33505192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33505192G>A	ENST00000404816.2	+	19	3432	c.3079G>A	c.(3079-3081)Gaa>Aaa	p.E1027K	LTBP1_ENST00000402934.1_Missense_Mutation_p.E648K|LTBP1_ENST00000354476.3_Missense_Mutation_p.E1028K|LTBP1_ENST00000404525.1_Missense_Mutation_p.E648K|LTBP1_ENST00000407925.1_Missense_Mutation_p.E701K|LTBP1_ENST00000390003.4_Missense_Mutation_p.E702K|LTBP1_ENST00000418533.2_Missense_Mutation_p.E701K			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1027	EGF-like 7; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCCCTGCACAGAAGGATTCCG	0.423000													15	82					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374541	8374541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8374541G>A	ENST00000538603.1	-	7	1830	c.1272C>T	c.(1270-1272)ctC>ctT	p.L424L	FAM90A1_ENST00000307435.6_Silent_p.L424L	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	424							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		GGCTCTGAGCGAGGAAGGCTC	0.592000													10	41					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42295569	42295569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:42295569G>A	ENST00000379310.3	-	25	2969	c.2901C>T	c.(2899-2901)gaC>gaT	p.D967D	VWA8_ENST00000281496.6_Silent_p.D967D	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		TAATCCCTTGGTCAGCCAAAC	0.473000													43	117					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70890760	70890760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70890760C>T	ENST00000264436.3	-	16	2422	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K	ADD2_ENST00000407644.2_Missense_Mutation_p.E660K|ADD2_ENST00000355733.3_3'UTR	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	660					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CTGAGGATTTCCTCTGCCGTC	0.577000													56	99					0	0	1	0	0
PDGFB	5155	broad.mit.edu	37	22	39631795	39631795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39631795C>T	ENST00000331163.6	-	2	935	c.148G>A	c.(148-150)Gga>Aga	p.G50R	PDGFB_ENST00000381551.4_Missense_Mutation_p.G35R	NM_002608.2	NP_002599.1	P01127	PDGFB_HUMAN	platelet-derived growth factor beta polypeptide	50					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(429)	central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Melanoma(58;0.04)				Becaplermin(DB00102)	CCGGGGTCTCCGTGCAGCAGG	0.617000			T	COL1A1	DFSP								8	23					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7340403	7340403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:7340403C>T	ENST00000486284.1	+	3	1043	c.769C>T	c.(769-771)Ccc>Tcc	p.P257S	GRM7_ENST00000357716.4_Missense_Mutation_p.P257S|GRM7_ENST00000403881.1_Missense_Mutation_p.P257S|GRM7_ENST00000402647.2_Missense_Mutation_p.P257S|GRM7_ENST00000389336.4_Missense_Mutation_p.P257S	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	257					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CGTGAGAATCCCCCAGGAACG	0.473000													33	63					0	0	1	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198420	91198420	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:91198420G>A	ENST00000341233.4	-	6	1269	c.879C>T	c.(877-879)tcC>tcT	p.S293S	SLC16A12_ENST00000371790.4_Silent_p.S323S	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	293						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						CTCCAAGTATGGACATAAGAA	0.443000													22	98					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1251138	1251138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1251138G>A	ENST00000308624.5	+	12	1057	c.928G>A	c.(928-930)Gct>Act	p.A310T	SNTG2_ENST00000407292.1_Missense_Mutation_p.A183T	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	310	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		ACTCCAAGGAGCTGACTCCTC	0.498000													13	34					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228505603	228505603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228505603G>A	ENST00000570156.2	+	64	16805	c.16731G>A	c.(16729-16731)ccG>ccA	p.P5577P	OBSCN_ENST00000366707.4_Silent_p.P2254P|OBSCN_ENST00000422127.1_Silent_p.P4620P|OBSCN_ENST00000284548.11_Silent_p.P4620P|OBSCN_ENST00000366709.4_Silent_p.P1739P	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4620					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding	p.P5202P(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGAGCCACCGAAGCCTGTGC	0.667000													3	11					0	0	1	0	0
DCUN1D3	123879	broad.mit.edu	37	16	20871407	20871407	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20871407G>A	ENST00000324344.3	-	3	1001	c.716C>T	c.(715-717)tCc>tTc	p.S239F	DCUN1D3_ENST00000563934.1_Missense_Mutation_p.S239F|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3	239	DCUN1.				negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		AGTGTCCCGGGAGATGCCCTT	0.507000													22	101					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46308052	46308052	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46308052C>T	ENST00000221538.3	-	3	1253	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	RSPH6A_ENST00000597055.1_Missense_Mutation_p.E371K|RSPH6A_ENST00000600188.1_Missense_Mutation_p.E107K	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	371	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						acctcctcctcctctgcctcc	0.652000													7	22					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101510519	101510519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101510519G>A	ENST00000392979.3	+	24	2769	c.2408G>A	c.(2407-2409)cGa>cAa	p.R803Q	ANO4_ENST00000550015.1_Missense_Mutation_p.R358Q|ANO4_ENST00000392977.3_Missense_Mutation_p.R838Q|ANO4_ENST00000299222.9_Missense_Mutation_p.R358Q	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	838						chloride channel complex	chloride channel activity	p.R803Q(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TTTGAGAACCGATCTGAGCCT	0.507000										HNSCC(74;0.22)			62	139					0	0	1	0	0
AKR1B15	441282	broad.mit.edu	37	7	134256405	134256405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:134256405G>A	ENST00000457545.2	+	6	745	c.485G>A	c.(484-486)gGa>gAa	p.G162E	AKR1B15_ENST00000423958.1_Missense_Mutation_p.G134E	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	162							oxidoreductase activity	p.G134V(1)|p.G134E(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						ATGATCAGTGGAAAAGGAACG	0.418000													26	126					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88367436	88367436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:88367436G>A	ENST00000419482.2	+	1	138	c.53G>A	c.(52-54)gGa>gAa	p.G18E	SMYD1_ENST00000444564.2_Missense_Mutation_p.G18E|SMYD1_ENST00000438570.1_Missense_Mutation_p.G18E	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	18					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						GAGGGCAAAGGAAGGGGTCTG	0.522000													68	147					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58639509	58639509	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58639509C>T	ENST00000358781.2	-	3	324		c.e3-1			NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D						negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CGAAGCACACCTGCTGAGCAA	0.532000													8	71					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30034149	30034149	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30034149C>T	ENST00000328224.6	-	2	1310	c.77G>A	c.(76-78)cGg>cAg	p.R26Q		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	26						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CTCCCGGGCCCGGGCCTGGGC	0.627000													27	132					0	0	1	0	0
CSH1	1442	broad.mit.edu	37	17	61972690	61972690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61972690G>A	ENST00000329882.8	-	4	669	c.599C>T	c.(598-600)cCt>cTt	p.P200L	CSH1_ENST00000453363.3_Intron|CSH1_ENST00000316193.8_Intron			P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 (placental lactogen)	0					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			central_nervous_system(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						AAGGCCTGGAGGATTCACCAG	0.527000									Russell-Silver syndrome				52	117					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28618371	28618371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28618371C>T	ENST00000395609.1	-	7	1158	c.400G>A	c.(400-402)Gat>Aat	p.D134N	SULT1A1_ENST00000569554.1_Missense_Mutation_p.D134N|SULT1A1_ENST00000314752.7_Missense_Mutation_p.D134N|SULT1A1_ENST00000350842.4_Missense_Mutation_p.D56N|SULT1A1_ENST00000395607.1_Missense_Mutation_p.D134N			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	134					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						ACTGCCACATCCTTTGCGTTG	0.572000													20	90					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169108797	169108797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169108797G>A	ENST00000256935.8	+	7	600	c.520G>A	c.(520-522)Gac>Aac	p.D174N		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	174					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAATATCTTGGACCCTGATAA	0.403000													45	144					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	488989	488989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:488989C>T	ENST00000230449.4	-	27	2806	c.2671G>A	c.(2671-2673)Gca>Aca	p.A891T	EXOC2_ENST00000448181.3_Missense_Mutation_p.A486T	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	891					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TTTTTATCTGCTCCACTGGAA	0.428000													76	174					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61868589	61868589	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61868589C>T	ENST00000280772.1	-	27	3363	c.3173_splice	c.e27+1	p.G1058_splice	ANK3_ENST00000503366.1_Splice_Site_p.G1059_splice|ANK3_ENST00000373827.2_Splice_Site_p.G1052_splice|ANK3_ENST00000355288.2_Splice_Site_p.G192_splice	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1058	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACAACTTACCCTAAAAATTGT	0.438000													8	51					0	0	1	0	0
C6orf15	29113	broad.mit.edu	37	6	31079766	31079766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31079766C>T	ENST00000259870.3	-	2	373	c.370G>A	c.(370-372)Gag>Aag	p.E124K		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	124								p.E124*(1)		endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						AGGCGGTCCTCAGCCGCAGCA	0.652000													13	60					0	0	1	0	0
PPP1R18	170954	broad.mit.edu	37	6	30652329	30652329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30652329G>A	ENST00000274853.3	-	1	3343	c.1467C>T	c.(1465-1467)acC>acT	p.T489T	PPP1R18_ENST00000399199.3_Silent_p.T489T|PPP1R18_ENST00000488324.1_Intron	NM_133471.3	NP_597728.1	Q6NYC8	PHTNS_HUMAN	protein phosphatase 1, regulatory subunit 18	489						cytoplasm|cytoskeleton	actin binding										TGGCTGGAGAGGTTGGGGTGG	0.687000													4	24					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23236971	23236971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23236971C>T	ENST00000400191.3	+	14	2617	c.2599C>T	c.(2599-2601)Cgc>Tgc	p.R867C	EPHB2_ENST00000374627.1_Missense_Mutation_p.R862C|EPHB2_ENST00000374630.3_Missense_Mutation_p.R867C|EPHB2_ENST00000374632.3_Missense_Mutation_p.R868C	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	867	Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GCAGAAGGACCGCAACCACCG	0.587000													28	68					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86198601	86198601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:86198601G>A	ENST00000361228.3	-	2	1555	c.1187C>T	c.(1186-1188)cCc>cTc	p.P396L		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	396					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGAGTAAAGGGAGGAATCTC	0.428000													17	122					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81532943	81532943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81532943G>A	ENST00000548058.1	+	4	1589	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	ACSS3_ENST00000261206.3_Missense_Mutation_p.E226K			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	227						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						ATTTGGCATTGAACCTGGAAG	0.338000													22	64					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127570141	127570141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127570141C>T	ENST00000373580.3	+	7	1250	c.1250C>T	c.(1249-1251)gCc>gTc	p.A417V	OLFML2A_ENST00000288815.5_Missense_Mutation_p.A203V	NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	417	Olfactomedin-like.									endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						CACGAGGGAGCCTGGATGAAG	0.612000													19	38					0	0	1	0	0
RASGRP4	115727	broad.mit.edu	37	19	38910780	38910780	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38910780G>T	ENST00000454404.2	-	5	713	c.500C>A	c.(499-501)tCt>tAt	p.S167Y	RASGRP4_ENST00000293062.9_Missense_Mutation_p.S167Y|RASGRP4_ENST00000586305.1_Missense_Mutation_p.S167Y|RASGRP4_ENST00000433821.2_Missense_Mutation_p.S167Y|RASGRP4_ENST00000426920.2_Missense_Mutation_p.S167Y|RASGRP4_ENST00000587753.1_Missense_Mutation_p.S167Y|RASGRP4_ENST00000587738.1_Missense_Mutation_p.S167Y	NM_001146205.1|NM_170604.2	NP_001139677.1|NP_733749.1	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4	167	N-terminal Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|prostate(3)|skin(1)	23	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAGGTCAGAAGAGTCTCCCAG	0.597000													5	35					0.00198382	0.00198545	1	1	0
ANK2	287	broad.mit.edu	37	4	114153329	114153329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114153329C>T	ENST00000357077.4	+	5	450	c.397C>T	c.(397-399)Cct>Tct	p.P133S	ANK2_ENST00000264366.6_Missense_Mutation_p.P133S|ANK2_ENST00000506722.1_Missense_Mutation_p.P112S|ANK2_ENST00000394537.3_Missense_Mutation_p.P133S	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	133					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGGCTTTACTCCTTTATACAT	0.393000													25	78					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945666	72945666	+	Silent	SNP	C	C	T	rs139591958	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72945666C>T	ENST00000311131.2	+	3	929	c.462C>T	c.(460-462)gcC>gcT	p.A154A	P2RY2_ENST00000393597.2_Silent_p.A154A|P2RY2_ENST00000393596.2_Silent_p.A154A	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	154					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	GCCGGGTGGCCGGGGCCGTGT	0.716000													13	68					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21036508	21036508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21036508G>A	ENST00000381545.3	+	13	1873	c.1654G>A	c.(1654-1656)Ggt>Agt	p.G552S	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G552S|LST3_ENST00000540229.1_Missense_Mutation_p.G552S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.G552S|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	552					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TGCAACAGGAGGTACCACATT	0.343000													12	111					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96961310	96961310	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96961310G>A	ENST00000323853.5	-	14	1835	c.1758C>T	c.(1756-1758)atC>atT	p.I586I	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	586	Helicase ATP-binding 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						GGGTGCAGACGATGATCTGAG	0.572000													18	49					0	0	1	0	0
CWC22	57703	broad.mit.edu	37	2	180846610	180846610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:180846610G>A	ENST00000410053.3	-	5	620	c.321C>T	c.(319-321)tcC>tcT	p.S107S	CWC22_ENST00000295749.6_Silent_p.S107S	NM_020943.2	NP_065994.1	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	107						catalytic step 2 spliceosome	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(8)|stomach(1)	30						CCTGAGCAGAGGAACTCTGAG	0.468000													8	18					0	0	1	0	0
GALNT5	11227	broad.mit.edu	37	2	158114750	158114750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158114750G>A	ENST00000259056.4	+	1	641	c.156G>A	c.(154-156)agG>agA	p.R52R		NM_014568.1	NP_055383.1	Q7Z7M9	GALT5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	52					glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(4)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	56						TTGTGAGGAGGGAGCGGATAG	0.483000													47	147					0	0	1	0	0
ANAPC16	119504	broad.mit.edu	37	10	73983730	73983730	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73983730G>T	ENST00000299381.4	+	2	176	c.58G>T	c.(58-60)Gga>Tga	p.G20*	ANAPC16_ENST00000470481.2_3'UTR	NM_001242546.1|NM_001242547.1|NM_001242548.1|NM_173473.3	NP_001229475.1|NP_001229476.1|NP_001229477.1|NP_775744.1	Q96DE5	APC16_HUMAN	anaphase promoting complex subunit 16	20	Ser-rich.				cell division|mitosis|protein ubiquitination	anaphase-promoting complex|cytoplasm				large_intestine(1)|ovary(1)	2						TTCTGTCACTGGATCTGGTTT	0.493000													51	122					1.17673e-23	1.18441e-23	1	1	0
COL5A3	50509	broad.mit.edu	37	19	10114360	10114360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10114360G>A	ENST00000264828.3	-	6	815	c.730C>T	c.(730-732)Cct>Tct	p.P244S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	244	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TTCCGCCGAGGACGAGGGGTT	0.582000													9	79					0	0	1	0	0
CETP	1071	broad.mit.edu	37	16	57009030	57009030	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57009030G>A	ENST00000200676.3	+	10	1078	c.948G>A	c.(946-948)tgG>tgA	p.W316*	CETP_ENST00000379780.2_Nonsense_Mutation_p.W256*|CETP_ENST00000566128.1_Nonsense_Mutation_p.W251*	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	316					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						TGGAGACCTGGGGCTTCAACA	0.537000													17	44					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247464567	247464567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247464567G>A	ENST00000294753.4	-	9	1482	c.1018C>T	c.(1018-1020)Ccg>Tcg	p.P340S	ZNF496_ENST00000366498.2_Missense_Mutation_p.P376S|ZNF496_ENST00000462139.1_5'UTR	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	340					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			AGAGATCGCGGGTTGCCGCCA	0.602000													15	73					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099974	133099974	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133099974C>T	ENST00000515826.1	+	3	1542	c.1419C>T	c.(1417-1419)atC>atT	p.I473I	TMEM108_ENST00000393130.3_Silent_p.I473I|TMEM108_ENST00000321871.6_Silent_p.I473I|TMEM108_ENST00000508711.1_Intron			Q6UXF1	TM108_HUMAN	transmembrane protein 108	473						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						CCTGGGTGATCCTGGCCATCA	0.602000													12	66					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71487187	71487187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71487187G>A	ENST00000393539.2	-	5	914	c.101C>T	c.(100-102)tCt>tTt	p.S34F	ZNF23_ENST00000564528.1_5'UTR|ZNF23_ENST00000539742.1_Intron|ZNF23_ENST00000417828.1_Missense_Mutation_p.S34F|ZNF23_ENST00000357254.4_Missense_Mutation_p.S34F|AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000428724.2_5'UTR|ZNF23_ENST00000358700.2_Missense_Mutation_p.S34F|ZNF23_ENST00000497160.1_Missense_Mutation_p.S34F	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	34	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		AGCCAGTGGAGATGAGCCCCC	0.517000													3	13					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139873732	139873732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139873732C>T	ENST00000224167.2	+	3	387	c.312C>T	c.(310-312)tcC>tcT	p.S104S	PTGDS_ENST00000371625.3_Silent_p.S104S|PTGDS_ENST00000460340.1_3'UTR			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	104					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCCTCGGCTCCTACAGCTACC	0.701000													28	78					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923308	43923308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43923308C>T	ENST00000329196.5	+	1	1053	c.1036C>T	c.(1036-1038)Cgc>Tgc	p.R346C	MAPT-AS1_ENST00000579244.1_RNA|MAPT-AS1_ENST00000579599.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	346						integral to membrane	aspartic-type endopeptidase activity										CAATGAGGACCGCTGGGCGTG	0.637000													17	23					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125487019	125487019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125487019C>T	ENST00000259466.1	+	1	751	c.751C>T	c.(751-753)Ctg>Ttg	p.L251L		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						TGTAGTGGTCCTGTTCTATGG	0.522000													12	133					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	409209	409209	+	Silent	SNP	G	G	A	rs140563600		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:409209G>A	ENST00000280886.6	-	21	2607	c.2520C>T	c.(2518-2520)atC>atT	p.I840I	DIP2C_ENST00000381496.3_3'UTR|DIP2C_ENST00000540204.1_Silent_p.I161I	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	840						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CCACGATCACGATCCTCTCGT	0.647000													18	42					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605341	171605341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171605341G>A	ENST00000037502.5	-	3	1298	c.1239C>T	c.(1237-1239)ctC>ctT	p.L413L		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	413	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AGGTTTGTTCGAGTTCCAGAT	0.522000													55	121					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234113017	234113017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234113017C>T	ENST00000359570.5	+	28	3185	c.3185C>T	c.(3184-3186)cCc>cTc	p.1062_1062insL	INPP5D_ENST00000455936.2_Missense_Mutation_p.826_826insL|INPP5D_ENST00000450745.1_Missense_Mutation_p.826_826insL			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	0	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GGCGAGGGGCCCGGCAAGCAG	0.706000													10	37					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84780088	84780088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:84780088C>T	ENST00000389394.3	+	10	1669	c.1532C>T	c.(1531-1533)cCc>cTc	p.P511L	DNAH6_ENST00000237449.6_Missense_Mutation_p.P511L|DNAH6_ENST00000398278.2_Missense_Mutation_p.P511L	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	511	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						TCTCTCATCCCCATGTTTCTC	0.398000													33	121					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15793285	15793285	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15793285G>A	ENST00000550308.1	+	6	992	c.612G>A	c.(610-612)caG>caA	p.Q204Q	CYP4F12_ENST00000324632.9_Silent_p.Q204Q	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ACAGTCTACAGAAATGCATCT	0.532000													39	146					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2401996	2401996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2401996G>A	ENST00000332578.3	+	4	436	c.436G>A	c.(436-438)Gaa>Aaa	p.E146K		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	146					proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCTTGGCAGAAAGAGACTT	0.443000													61	211					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130613	20130613	+	Missense_Mutation	SNP	C	C	T	rs140830467		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20130613C>T	ENST00000334554.7	+	10	1601	c.1460C>T	c.(1459-1461)tCg>tTg	p.S487L	ZDHHC8_ENST00000405930.3_Missense_Mutation_p.S487L|ZDHHC8_ENST00000320602.7_Missense_Mutation_p.S395L	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	487						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					AATCCTGGCTCGCCTGGTGGC	0.697000													21	51					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152083782	152083782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152083782C>T	ENST00000368804.1	-	2	1910	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	637	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCCTGCTCCTCGCTCTTCA	0.677000													20	142					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15608549	15608549	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:15608549G>A	ENST00000281513.5	-	17	1859	c.1834C>T	c.(1834-1836)Ctg>Ttg	p.L612L	NBAS_ENST00000441750.1_Silent_p.L612L	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	612										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						AGAGCCTCCAGGTCTGTGCCT	0.413000													40	148					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57057430	57057430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:57057430G>A	ENST00000308249.2	+	7	1435	c.1306G>A	c.(1306-1308)Ggc>Agc	p.G436S		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	445	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			GGCCTGTGATGGCTTCTATGA	0.498000													15	30					0	0	1	0	0
LMAN2L	81562	broad.mit.edu	37	2	97373078	97373078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97373078G>A	ENST00000264963.4	-	8	984	c.962C>T	c.(961-963)tCc>tTc	p.S321F	LMAN2L_ENST00000426463.2_Missense_Mutation_p.S187F|LMAN2L_ENST00000377079.4_Missense_Mutation_p.S332F|LMAN2L_ENST00000537039.1_Missense_Mutation_p.S183F|LMAN2L_ENST00000534882.1_Missense_Mutation_p.S176F	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	321					ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						AAACACCAGGGAGAAAAAGAC	0.522000													19	35					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152323637	152323637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152323637C>T	ENST00000388718.5	-	3	6697	c.6625G>A	c.(6625-6627)Gga>Aga	p.G2209R	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2209							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGACTGTCCATGTCGAGAT	0.507000													41	468					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76023520	76023520	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76023520G>A	ENST00000393004.2	-	5	2249	c.2028C>T	c.(2026-2028)ttC>ttT	p.F676F	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Silent_p.F676F|FILIP1_ENST00000370020.1_Silent_p.F577F			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	676								p.F676F(1)		breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GTTGAGAGAGGAAGTTAGCCT	0.433000													117	202					0	0	1	0	0
MEF2A	4205	broad.mit.edu	37	15	100214787	100214787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:100214787C>T	ENST00000354410.5	+	6	1215	c.586C>T	c.(586-588)Cct>Tct	p.P196S	MEF2A_ENST00000557942.1_Missense_Mutation_p.P194S|MEF2A_ENST00000449277.2_Missense_Mutation_p.P126S|MEF2A_ENST00000558812.1_Missense_Mutation_p.P126S|MEF2A_ENST00000453228.2_Missense_Mutation_p.P194S|MEF2A_ENST00000338042.6_Missense_Mutation_p.P194S|MEF2A_ENST00000557785.1_Missense_Mutation_p.P194S	NM_005587.2	NP_005578.2	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A	196					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding	p.P196S(2)|p.P194S(1)		endometrium(2)|large_intestine(2)|lung(7)|ovary(1)	12	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			TCCTGGAGCTCCTCAGAGACC	0.433000													14	182					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107018	121107018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:121107018C>T	ENST00000295228.3	+	2	838	c.792C>T	c.(790-792)ttC>ttT	p.F264F		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	264					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				TGCCGGTGTTCGTGGACCCAG	0.667000													37	91					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20709625	20709625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20709625G>A	ENST00000359062.3	+	2	1032	c.992G>A	c.(991-993)cGa>cAa	p.R331Q		NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	331					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GACCACAAACGAGGGCCAAGA	0.348000													17	146					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160093842	160093842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160093842C>T	ENST00000361216.3	+	5	580	c.491C>T	c.(490-492)cCt>cTt	p.P164L	ATP1A2_ENST00000392233.3_Missense_Mutation_p.P164L|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	164					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AACATGGTACCTCAGGTAAGA	0.532000													17	57					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64421078	64421078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:64421078C>T	ENST00000262043.3	+	15	4157	c.3817C>T	c.(3817-3819)Cgc>Tgc	p.R1273C	PHF3_ENST00000393387.1_Missense_Mutation_p.R1273C			Q92576	PHF3_HUMAN	PHD finger protein 3	1273					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TTGTGTGGTTCGCTTCACACC	0.323000													10	31					0	0	1	0	0
FUT5	2527	broad.mit.edu	37	19	5867495	5867495	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5867495C>T	ENST00000252675.5	-	5	804	c.242G>A	c.(241-243)tGg>tAg	p.W81*	FUT5_ENST00000588525.1_Nonsense_Mutation_p.W81*			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	81					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						AGGCCACGTCCACAGCAGGAT	0.652000													17	59					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58055936	58055936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:58055936G>A	ENST00000556826.1	-	3	821	c.585C>T	c.(583-585)ttC>ttT	p.F195F	SLC35F4_ENST00000339762.6_Silent_p.F231F|SLC35F4_ENST00000554729.1_Silent_p.F72F	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AAACCTACCTGAATTTTTTCA	0.338000													30	77					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44004474	44004474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44004474G>A	ENST00000262726.7	-	22	2822	c.2569C>T	c.(2569-2571)Cta>Tta	p.L857L	EFCAB6_ENST00000396231.2_Silent_p.L705L	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	857	EF-hand 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TCGGTTTCTAGAAAATTCTAC	0.398000													36	57					0	0	1	0	0
SLC26A6	65010	broad.mit.edu	37	3	48663735	48663735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48663735G>A	ENST00000358747.6	-	19	2368	c.2118C>T	c.(2116-2118)acC>acT	p.T706T	SLC26A6_ENST00000455886.2_Silent_p.T691T|SLC26A6_ENST00000337000.8_Silent_p.T619T|SLC26A6_ENST00000420764.2_Silent_p.T726T|SLC26A6_ENST00000395550.2_Silent_p.T727T|SLC26A6_ENST00000383733.3_Silent_p.T708T	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		GATGCTTCTTGGTGATGGATG	0.582000													13	79					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71976274	71976274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71976274G>A	ENST00000266674.5	+	17	1902	c.1591G>A	c.(1591-1593)Gaa>Aaa	p.E531K	LGR5_ENST00000536515.1_Missense_Mutation_p.E459K|LGR5_ENST00000540815.2_Missense_Mutation_p.E507K|RP11-186F10.2_ENST00000546601.1_RNA			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	531						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TGACTTTGAGGAAGACCTGAA	0.463000													9	89					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13418643	13418643	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13418643G>A	ENST00000360228.5	-	15	1938	c.1939C>T	c.(1939-1941)Ccc>Tcc	p.P647S	CACNA1A_ENST00000573710.2_Missense_Mutation_p.P648S	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	648					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AAGTTGGTGGGAGGAGTCCCT	0.542000													27	83					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640283	34640283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34640283G>A	ENST00000537011.1	+	3	596	c.214G>A	c.(214-216)Gag>Aag	p.E72K	NUTM1_ENST00000438749.3_Missense_Mutation_p.E62K|NUTM1_ENST00000333756.4_Missense_Mutation_p.E44K					NUT midline carcinoma, family member 1																		CCCACCCAGGGAGCCACCTCC	0.592000													50	126					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469264	10469264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10469264C>T	ENST00000382483.3	-	4	2567	c.2344G>A	c.(2344-2346)Gac>Aac	p.D782N		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	782					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GAGCAGGAGTCGGATGTGTGG	0.667000													13	83					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231120199	231120199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231120199G>A	ENST00000392045.3	+	12	1306	c.1192G>A	c.(1192-1194)Gga>Aga	p.G398R	SP140_ENST00000417495.3_Missense_Mutation_p.G284R|SP140_ENST00000343805.6_Missense_Mutation_p.G338R|SP140_ENST00000486687.2_Missense_Mutation_p.G322R|SP140_ENST00000350136.5_Missense_Mutation_p.G267R|SP140_ENST00000420434.3_Intron	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	398					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AATGTGTGATGGAGAAGAGCG	0.527000													22	72					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11702695	11702695	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11702695C>T	ENST00000381486.2	+	3	564	c.264C>T	c.(262-264)tgC>tgT	p.C88C	GREB1_ENST00000389825.3_5'UTR|GREB1_ENST00000234142.5_Silent_p.C88C|GREB1_ENST00000263834.5_Silent_p.C88C|GREB1_ENST00000381483.2_Silent_p.C88C	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	88						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CTGAAGGATGCTGTACCACAG	0.627000													21	109					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149260062	149260062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:149260062C>T	ENST00000407073.1	+	13	5318	c.4321C>T	c.(4321-4323)Cgg>Tgg	p.R1441W	MBD5_ENST00000404807.1_Missense_Mutation_p.R1674W	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1441	PWWP.					chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CAGCCGTGTCCGGAAAAGGAA	0.413000													9	41					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76928970	76928970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:76928970C>T	ENST00000380887.2	+	3	552	c.480C>T	c.(478-480)ttC>ttT	p.F160F	ESRRB_ENST00000261532.7_Silent_p.F160F|ESRRB_ENST00000509242.1_Silent_p.F160F|ESRRB_ENST00000507951.1_3'UTR|ESRRB_ENST00000556177.1_Silent_p.F160F			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	160						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CCTGCCGCTTCATGAAATGCC	0.582000													52	113					0	0	1	0	0
GM2A	2760	broad.mit.edu	37	5	150646957	150646957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150646957G>A	ENST00000357164.3	+	4	852	c.527G>A	c.(526-528)aGc>aAc	p.S176N		NM_000405.4|NM_001167607.1	NP_000396.2|NP_001161079.1	P17900	SAP3_HUMAN	GM2 ganglioside activator	176						lysosome|nucleolus	sphingolipid activator protein activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|upper_aerodigestive_tract(2)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTCCTGAGCAGCAGTGGGAAG	0.577000													12	51					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103124627	103124627	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103124627C>T	ENST00000295269.4	+	5	1745	c.1288C>T	c.(1288-1290)Cga>Tga	p.R430*		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	430					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CAGTGGTGTTCGAGGAGCTGG	0.413000													39	86					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6925421	6925421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6925421C>T	ENST00000011653.4	+	6	1065	c.807C>T	c.(805-807)gaC>gaT	p.D269D	CD4_ENST00000538827.1_3'UTR|CD4_ENST00000541982.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	269	Ig-like C2-type 2.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding	p.D269E(1)		breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				TTACCCAGGACCCTAAGCTCC	0.587000													25	95					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43332482	43332482	+	Silent	SNP	C	C	T	rs148517689		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43332482C>T	ENST00000380486.3	-	7	1153	c.912G>A	c.(910-912)acG>acA	p.T304T	C2CD2_ENST00000329623.7_Silent_p.T149T	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	304	C2.					cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						GAGTGTTTTTCGTCAGGGTGC	0.542000													3	22					0	0	1	0	0
BIRC8	112401	broad.mit.edu	37	19	53793021	53793021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53793021G>A	ENST00000426466.1	-	1	1854	c.607C>T	c.(607-609)Cct>Tct	p.P203S		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	203					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		TGTCCACAAGGAATAAAAACA	0.438000													25	81					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64514191	64514191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64514191C>T	ENST00000164139.3	-	20	2867	c.2469G>A	c.(2467-2469)cgG>cgA	p.R823R	PYGM_ENST00000377432.3_Silent_p.R735R	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	823					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	CCCAGATCTCCCGGGCATACT	0.617000													20	63					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10083692	10083692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10083692C>T	ENST00000264828.3	-	51	3762	c.3677G>A	c.(3676-3678)gGa>gAa	p.G1226E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1226	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			ACCAATGTCTCCCTTGGGCCC	0.577000													8	16					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294748	124294748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124294748G>A	ENST00000356130.3	-	1	41	c.20C>T	c.(19-21)tCc>tTc	p.S7F		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S7F(1)		endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGTCACTGAGGAGCTGTTTCT	0.483000													10	44					0	0	1	0	0
SLC20A2	6575	broad.mit.edu	37	8	42320605	42320605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42320605G>A	ENST00000342228.3	-	4	803	c.434C>T	c.(433-435)gCt>gTt	p.A145V	SLC20A2_ENST00000520262.1_Missense_Mutation_p.A145V|SLC20A2_ENST00000520179.1_Missense_Mutation_p.A145V	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	145					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AAACCAAGAAGCAACTGAATA	0.308000													4	42					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113562671	113562671	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113562671C>T	ENST00000416899.2	+	13	2115	c.1989C>T	c.(1987-1989)tcC>tcT	p.S663S	MUSK_ENST00000189978.5_Silent_p.S671S|MUSK_ENST00000374448.4_Silent_p.S671S			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	671	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						GCAGCATGTCCCCTCACACCG	0.572000													35	120					0	0	1	0	0
C18orf25	147339	broad.mit.edu	37	18	43796350	43796350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43796350C>T	ENST00000282059.6	+	2	878	c.504C>T	c.(502-504)gtC>gtT	p.V168V	C18orf25_ENST00000321319.6_Silent_p.V168V	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	168										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						ATGGCCGAGTCGCCAAGGTTA	0.517000													20	74					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885004	29885004	+	Missense_Mutation	SNP	G	G	A	rs59297913		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29885004G>A	ENST00000310624.6	+	4	1408	c.1375G>A	c.(1375-1377)Gaa>Aaa	p.E459K		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	459	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						GATTGTGGAGGAACAGACAGA	0.478000													17	48					0	0	1	0	0
APOL1	8542	broad.mit.edu	37	22	36661745	36661745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36661745G>A	ENST00000319136.4	+	7	1178	c.911G>A	c.(910-912)cGa>cAa	p.R304Q	APOL1_ENST00000347595.7_Missense_Mutation_p.R167Q|APOL1_ENST00000422706.1_Missense_Mutation_p.R288Q|APOL1_ENST00000426053.1_Missense_Mutation_p.R270Q|APOL1_ENST00000397279.4_Missense_Mutation_p.R288Q|APOL1_ENST00000397278.3_Missense_Mutation_p.R288Q	NM_145343.2	NP_663318.1	O14791	APOL1_HUMAN	apolipoprotein L, 1	288					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	14						GCCCTCAGACGAGCCAGAGCC	0.537000													29	83					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48428731	48428731	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48428731G>A	ENST00000224605.2	-	2	1420	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	385					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity	p.F385F(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CGATGTCTGCGAAGTCCACCT	0.552000													34	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060664	9060664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9060664C>T	ENST00000397910.4	-	3	26985	c.26782G>A	c.(26782-26784)Gag>Aag	p.E8928K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8930	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCTCTGTCTCCATGGTGGCT	0.488000													63	184					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870387	4870387	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4870387G>A	ENST00000322101.2	-	1	127	c.52C>T	c.(52-54)Ccc>Tcc	p.P18S	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGAAGGTGGGGGCCATTGAA	0.507000													36	77					0	0	1	0	0
RSPO1	284654	broad.mit.edu	37	1	38078497	38078497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38078497C>T	ENST00000356545.2	-	8	1509	c.722G>A	c.(721-723)aGa>aAa	p.R241K	RSPO1_ENST00000401069.1_Missense_Mutation_p.R241K|RSPO1_ENST00000373059.1_Missense_Mutation_p.R214K|RSPO1_ENST00000401070.1_Missense_Mutation_p.R178K|RSPO1_ENST00000401071.2_Missense_Mutation_p.R178K|RSPO1_ENST00000401068.1_Missense_Mutation_p.R241K	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1	241					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCCTTGCGTCTTCGAGAGCC	0.652000													38	109					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169697034	169697034	+	Silent	SNP	C	C	T	rs147467969	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169697034C>T	ENST00000333360.7	-	9	1453	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367775.1_Silent_p.K313K|SELE_ENST00000367774.1_Intron|SELE_ENST00000367782.4_Intron|SELE_ENST00000367779.4_Intron|SELE_ENST00000367781.4_Silent_p.K375K|SELE_ENST00000367777.1_Intron|SELE_ENST00000367776.1_Silent_p.K375K|SELE_ENST00000367780.4_Silent_p.K313K	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	438	Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TCACCAAACCCTTCGGGGGCT	0.488000													28	92					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28828806	28828806	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:28828806G>A	ENST00000422425.2	+	41	3059	c.3015G>A	c.(3013-3015)tgG>tgA	p.W1005*	PLB1_ENST00000541605.1_Intron|PLB1_ENST00000327757.5_Nonsense_Mutation_p.W1016*	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1016	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GAGCCCTTTGGACCAATATGG	0.522000													58	141					0	0	1	0	0
ZNF429	353088	broad.mit.edu	37	19	21720271	21720271	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21720271G>A	ENST00000358491.4	+	4	1624	c.1416G>A	c.(1414-1416)agG>agA	p.R472R	ZNF429_ENST00000597078.1_Intron	NM_001001415.2	NP_001001415.2	Q86V71	ZN429_HUMAN	zinc finger protein 429	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(13)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	34						CTAGCCATAGGAGAATTCATA	0.383000													23	89					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17353332	17353332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:17353332C>T	ENST00000261381.6	-	3	510	c.426G>A	c.(424-426)ccG>ccA	p.P142P		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	142					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTTTCTCTTTCGGCCGATGAG	0.478000													23	81					0	0	1	0	0
TIA1	7072	broad.mit.edu	37	2	70441545	70441545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70441545G>A	ENST00000433529.2	-	12	1180	c.970C>T	c.(970-972)Cct>Tct	p.P324S	TIA1_ENST00000415783.2_Missense_Mutation_p.P313S|TIA1_ENST00000445587.1_Intron|TIA1_ENST00000282574.4_Missense_Mutation_p.P323S|C2orf42_ENST00000470096.1_Intron	NM_022173.2	NP_071505.2	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein	324					apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	17						CAACCATTAGGCATATACTGG	0.403000													16	62					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23713758	23713758	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23713758C>T	ENST00000256797.4	-	10	1346	c.1178G>A	c.(1177-1179)aGa>aAa	p.R393K	ERN2_ENST00000457008.2_Missense_Mutation_p.R345K	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	345					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TGAGGGGTATCTAACAGCAGT	0.582000													51	140					0	0	1	0	0
TRBV4-1	28617	broad.mit.edu	37	7	142013066	142013066	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142013066C>T	ENST00000390357.3	+	0	60																											CTGTGCGGTTCTCTGTCTCCT	0.592000													32	57					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497184	141497184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141497184C>T	ENST00000264952.2	+	1	195	c.58C>T	c.(58-60)Cgg>Tgg	p.R20W		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	20					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CCTGCAGGCCCGGAAGCCCTC	0.697000													35	72					0	0	1	0	0
RBP1	5947	broad.mit.edu	37	3	139237318	139237318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:139237318C>T	ENST00000232219.2	-	3	595	c.485G>A	c.(484-486)gGt>gAt	p.G162D	RP11-319G6.1_ENST00000515247.1_RNA	NM_002899.3	NP_002890.2	P09455	RET1_HUMAN	retinol binding protein 1, cellular	100						cytoplasm	retinal binding|retinol binding|transporter activity			endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	5					Vitamin A(DB00162)	CTCCTTCTCACCCTTCTGCAC	0.612000													5	79					0	0	1	0	0
SRSF6	6431	broad.mit.edu	37	20	42088473	42088473	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42088473C>T	ENST00000244020.3	+	3	425	c.319C>T	c.(319-321)Cgt>Tgt	p.R107C		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	107					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding	p.R107C(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						ACCACCTGTTCGTACAGAATA	0.393000													37	111					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68777148	68777148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68777148C>T	ENST00000508048.1	-	10	1201	c.1166G>A	c.(1165-1167)gGa>gAa	p.G389E	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.G390E|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.G393E			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	393	Peptidase S1.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						ACAGTTATCTCCCCAGCTTAC	0.388000													31	102					0	0	1	0	0
KIF3A	11127	broad.mit.edu	37	5	132062122	132062122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132062122G>A	ENST00000378746.4	-	3	567	c.349C>T	c.(349-351)Cct>Tct	p.P117S	KIF3A_ENST00000378735.1_Missense_Mutation_p.P117S|KIF3A_ENST00000403231.1_Missense_Mutation_p.P117S	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	117	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTAAGTTCAGGAATAGCTCGA	0.368000													36	111					0	0	1	0	0
C17orf64	124773	broad.mit.edu	37	17	58506739	58506739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58506739C>T	ENST00000269127.4	+	5	530	c.446C>T	c.(445-447)tCg>tTg	p.S149L		NM_181707.2	NP_859058.2	Q86WR6	CQ064_HUMAN	chromosome 17 open reading frame 64	149										breast(2)|large_intestine(1)|lung(3)	6	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;5.81e-13)|all cancers(12;2.17e-11)|Colorectal(3;0.01)			TTCTGCGCCTCGGATGCGCCG	0.587000													12	42					0	0	1	0	0
C20orf96	140680	broad.mit.edu	37	20	257964	257964	+	Missense_Mutation	SNP	T	T	C	rs144025240		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:257964T>C	ENST00000360321.2	-	7	764	c.626A>G	c.(625-627)aAc>aGc	p.N209S	C20orf96_ENST00000400269.3_Missense_Mutation_p.N151S|C20orf96_ENST00000382369.5_Missense_Mutation_p.N174S	NM_080571.1|NM_153269.2	NP_542138.1|NP_695001.2	Q9NUD7	CT096_HUMAN	chromosome 20 open reading frame 96	209										endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12		all_cancers(10;0.00959)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GCTCAGGAAGTTCACTTCCTC	0.537000													90	209					0	0	1	0	0
CD48	962	broad.mit.edu	37	1	160648910	160648910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160648910C>T	ENST00000368046.3	-	4	751	c.664G>A	c.(664-666)Gga>Aga	p.G222R	RP11-404F10.2_ENST00000443928.2_RNA|RP11-404F10.2_ENST00000588034.1_RNA	NM_001778.3	NP_001769.2	P09326	CD48_HUMAN	CD48 molecule	222					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CATTCTACTCCAAAGGACCGG	0.453000													17	48					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52508883	52508883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52508883G>A	ENST00000216286.5	-	7	1764	c.1765C>T	c.(1765-1767)Ctg>Ttg	p.L589L	NID2_ENST00000541773.1_Silent_p.L536L	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	589	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CAGCCAAACAGGCCTCCAATT	0.582000													79	138					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80203349	80203349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:80203349C>T	ENST00000392959.1	-	5	1450	c.839G>A	c.(838-840)cGa>cAa	p.R280Q	LCA5_ENST00000467898.2_Missense_Mutation_p.R280Q|LCA5_ENST00000369846.4_Missense_Mutation_p.R280Q	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	280					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		GTGATATAGTCGCTGTACCTC	0.308000													19	27					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914337	107914337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107914337C>T	ENST00000280758.5	+	2	1737	c.1209C>T	c.(1207-1209)ccC>ccT	p.P403P	BTBD11_ENST00000420571.2_Silent_p.P403P|BTBD11_ENST00000490090.2_Silent_p.P403P	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	403						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GGGAACTGCCCATGTTCAGCC	0.567000													13	128					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33031966	33031966	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:33031966C>T	ENST00000340811.4	-	2	332	c.223_splice	c.e2-1	p.G75_splice	PKP2_ENST00000070846.6_Splice_Site_p.G75_splice	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	75					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GTGAAGATTTCCTGCAATCAA	0.333000													5	42					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572149	140572149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140572149C>T	ENST00000239446.4	+	1	208	c.24C>T	c.(22-24)ttC>ttT	p.F8F		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		8					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTTGTGCTTCCCAAGACAAA	0.473000													58	158					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593660	179593660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179593660C>T	ENST00000589042.1	-	65	19329	c.19105G>A	c.(19105-19107)Gag>Aag	p.E6369K	TTN_ENST00000342992.6_Missense_Mutation_p.E5125K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E6052K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6052	Ig-like 45.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCTGACTCATTCTTGGCT	0.388000													13	21					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11058943	11058943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11058943G>A	ENST00000287766.4	+	3	467	c.46G>A	c.(46-48)Gag>Aag	p.E16K	SLC6A1_ENST00000536032.1_5'UTR|SLC6A1_ENST00000462473.1_3'UTR|SLC6A1-AS1_ENST00000414969.2_RNA	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	16					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	GATCTCCACCGAGGTCAGCGA	0.642000													16	55					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17446124	17446124	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17446124C>A	ENST00000400588.1	-	7	1430	c.1323G>T	c.(1321-1323)agG>agT	p.R441S		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	441										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				CATTGATGACCCTGTTGTTTC	0.557000													10	37					1.08611e-07	1.08932e-07	1	1	0
VPS13D	55187	broad.mit.edu	37	1	12343258	12343258	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12343258T>A	ENST00000358136.3	+	21	5229	c.5099T>A	c.(5098-5100)tTa>tAa	p.L1700*	VPS13D_ENST00000356315.4_Nonsense_Mutation_p.L1700*	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1700					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCATCTAGTTTAGCACAAAAA	0.468000													54	113					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915564	119915564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:119915564G>A	ENST00000331113.4	+	1	1843	c.878G>A	c.(877-879)cGa>cAa	p.R293Q		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	293					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GTCACACTCCGAGTCTTCCGG	0.527000													14	31					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898490	175898490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175898490G>A	ENST00000359240.3	+	5	2484	c.1814G>A	c.(1813-1815)gGg>gAg	p.G605E	ADAM29_ENST00000404450.4_Missense_Mutation_p.G605E|ADAM29_ENST00000445694.1_Missense_Mutation_p.G605E|ADAM29_ENST00000514159.1_Missense_Mutation_p.G605E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	605	Cys-rich.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		ACAGAGTGTGGGATAGATCAT	0.428000													46	157					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28592681	28592681	+	Missense_Mutation	SNP	C	C	T	rs148480385		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28592681C>T	ENST00000380982.4	-	20	2545	c.2464G>A	c.(2464-2466)Ggg>Agg	p.G822R	FLT3_ENST00000537084.1_Intron|FLT3_ENST00000241453.7_Missense_Mutation_p.G822R			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	822	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACCACTTTCCCGTGGGTGACA	0.463000			"""Mis, O"""		"""AML, ALL"""								17	72					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102057327	102057327	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102057327G>A	ENST00000318222.3	-	5	1150	c.768C>T	c.(766-768)ttC>ttT	p.F256F	PKD2L1_ENST00000338519.3_Intron|PKD2L1_ENST00000353274.3_Silent_p.F256F	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	256					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CCCAGTGGGAGAAGCCCCCCA	0.592000													8	40					0	0	1	0	0
GIPR	2696	broad.mit.edu	37	19	46177384	46177384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46177384C>T	ENST00000590918.1	+	6	536	c.437C>T	c.(436-438)tCc>tTc	p.S146F	GIPR_ENST00000304207.8_Missense_Mutation_p.S110F|GIPR_ENST00000263281.3_Missense_Mutation_p.S146F	NM_000164.2	NP_000155.1	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	146					generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				endometrium(1)|kidney(2)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	12		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		GTCGGCTACTCCCTGTCTCTC	0.592000													64	178					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156651215	156651215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156651215C>T	ENST00000296518.7	+	10	2114	c.1905C>T	c.(1903-1905)acC>acT	p.T635T	GUCY1A3_ENST00000511108.1_Silent_p.T635T|GUCY1A3_ENST00000455639.2_Silent_p.T635T|GUCY1A3_ENST00000513574.1_Silent_p.T635T|GUCY1A3_ENST00000393832.3_Silent_p.T377T|GUCY1A3_ENST00000506455.1_Silent_p.T635T			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	635					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity	p.T635T(1)		central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TCGTGTTTACCCCTCGATCAA	0.378000													17	97					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233394685	233394685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233394685G>A	ENST00000258385.3	+	7	688	c.656G>A	c.(655-657)aGg>aAg	p.R219K	CHRND_ENST00000536614.1_Silent_p.Q182Q|CHRND_ENST00000543200.1_Missense_Mutation_p.R204K|CHRND_ENST00000457943.2_Intron	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	219					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CGGCCGGCCAGGGTCAACGTG	0.647000													18	99					0	0	1	0	0
TNNT1	7138	broad.mit.edu	37	19	55652271	55652271	+	Missense_Mutation	SNP	C	C	T	rs150477069		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55652271C>T	ENST00000588981.1	-	9	571	c.367G>A	c.(367-369)Gaa>Aaa	p.E123K	TNNT1_ENST00000587758.1_Missense_Mutation_p.E112K|TNNT1_ENST00000592920.1_5'UTR|TNNT1_ENST00000291901.8_Missense_Mutation_p.E123K|TNNT1_ENST00000356783.5_Missense_Mutation_p.E112K|TNNT1_ENST00000585321.2_Missense_Mutation_p.E53K|TNNT1_ENST00000536926.1_Missense_Mutation_p.E112K|TNNT1_ENST00000588426.1_Missense_Mutation_p.E20K|TNNT1_ENST00000587465.2_Missense_Mutation_p.E53K	NM_003283.4	NP_003274.3	P13805	TNNT1_HUMAN	troponin T type 1 (skeletal, slow)	123					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		GCCTGACGTTCGCGTTCCTTC	0.552000													39	50					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169711903	169711903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169711903G>A	ENST00000444448.2	+	14	1544	c.1068G>A	c.(1066-1068)aaG>aaA	p.K356K	NOSTRIN_ENST00000421711.2_Silent_p.K271K|NOSTRIN_ENST00000397206.2_Silent_p.K221K|NOSTRIN_ENST00000458381.2_Silent_p.K356K|NOSTRIN_ENST00000317647.7_Silent_p.K299K|NOSTRIN_ENST00000445023.2_Silent_p.K221K|NOSTRIN_ENST00000397209.2_Silent_p.K271K			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	299					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						AGAGACGAAAGTCTTTACTAA	0.388000													10	66					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701922	56701922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56701922C>T	ENST00000586855.2	-	5	1075	c.762G>A	c.(760-762)ggG>ggA	p.G254G	ZSCAN5B_ENST00000358992.3_Silent_p.G254G			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	254					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GGGGTTCCTTCCCCTCCTTTG	0.488000													37	81					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32379054	32379054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32379054C>T	ENST00000375200.1	+	15	2661	c.2296C>T	c.(2296-2298)Ccc>Tcc	p.P766S	RP4-553F4.6_ENST00000443171.1_RNA|RP4-553F4.6_ENST00000439444.1_RNA|RP4-553F4.6_ENST00000423074.1_RNA|ZNF341_ENST00000342427.2_Missense_Mutation_p.P759S			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	766					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GGTGCTGACCCCCTTGCCTGA	0.721000													15	29					0	0	1	0	0
IFNL3	282617	broad.mit.edu	37	19	39735067	39735067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39735067C>T	ENST00000413851.2	-	2	286	c.248G>A	c.(247-249)aGg>aAg	p.R83K		NM_172139.2	NP_742151.2			interferon, lambda 3																		CTGCAGCTGCCTCAGGTCCCA	0.632000													4	25					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43243749	43243749	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43243749G>A	ENST00000255226.6	+	11	2167		c.e11-1		SLC14A2_ENST00000586448.1_Splice_Site	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2							apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCCCTGGCTAGGAGGCGGTGG	0.582000													17	32					0	0	1	0	0
EYA2	2139	broad.mit.edu	37	20	45725748	45725748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45725748G>A	ENST00000327619.5	+	9	1203	c.829G>A	c.(829-831)Gag>Aag	p.E277K	EYA2_ENST00000317304.6_Missense_Mutation_p.E277K|EYA2_ENST00000357410.3_Missense_Mutation_p.E277K	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	277					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				GGACTTGGATGAGACAATAAT	0.403000													60	183					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74631996	74631996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74631996G>A	ENST00000358632.4	-	6	1310	c.615C>T	c.(613-615)gcC>gcT	p.A205A	CYP11A1_ENST00000268053.6_Silent_p.A363A|CYP11A1_ENST00000419019.2_Silent_p.A205A	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	363					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TGTCTCCCTGGGCCTGGTGCC	0.612000													36	35					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118196347	118196347	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118196347C>T	ENST00000369230.3	+	2	320	c.174C>T	c.(172-174)ctC>ctT	p.L58L		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	58					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		GTTTCCTGCTCTACACTATAC	0.408000													17	159					0	0	1	0	0
CTC-260F20.3	0	broad.mit.edu	37	19	19638102	19638102	+	Silent	SNP	C	C	T	rs140748603		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19638102C>T	ENST00000555938.1	+	3	198	c.186C>T	c.(184-186)atC>atT	p.I62I	NDUFA13_ENST00000503283.1_Silent_p.I62I|NDUFA13_ENST00000428459.2_Silent_p.I62I|NDUFA13_ENST00000507754.3_Silent_p.I62I|NDUFA13_ENST00000252576.5_Silent_p.I145I|CTC-260F20.3_ENST00000586674.1_3'UTR																							GCCTACAAATCGAGGACTTCG	0.637000													23	50					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042757	75042757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75042757C>T	ENST00000343932.4	+	2	741	c.678C>T	c.(676-678)ttC>ttT	p.F226F		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	226					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding	p.F226F(2)		breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CTCATGAGTTCGTGGAGACTG	0.572000													38	252					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124395538	124395538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124395538G>A	ENST00000368909.3	+	50	6299	c.6193G>A	c.(6193-6195)Gaa>Aaa	p.E2065K	DMBT1_ENST00000330163.4_Missense_Mutation_p.E1437K|DMBT1_ENST00000368955.3_Missense_Mutation_p.E2055K|DMBT1_ENST00000359586.6_Missense_Mutation_p.E785K|DMBT1_ENST00000368956.2_Missense_Mutation_p.E1437K|DMBT1_ENST00000344338.3_Missense_Mutation_p.E2055K|DMBT1_ENST00000338354.3_Missense_Mutation_p.E2065K	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2065	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGATTATATTGAAGTTTTCGA	0.507000													19	52					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169698359	169698359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169698359C>T	ENST00000333360.7	-	7	1197	c.1058G>A	c.(1057-1059)gGg>gAg	p.G353E	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367775.1_Missense_Mutation_p.G291E|SELE_ENST00000367774.1_Missense_Mutation_p.G353E|SELE_ENST00000367782.4_Missense_Mutation_p.G353E|SELE_ENST00000367779.4_Missense_Mutation_p.G353E|SELE_ENST00000367781.4_Missense_Mutation_p.G353E|SELE_ENST00000367777.1_Missense_Mutation_p.G353E|SELE_ENST00000367776.1_Missense_Mutation_p.G353E|SELE_ENST00000367780.4_Missense_Mutation_p.G291E	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	353	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TGTCCACTGCCCTTGAGTGGT	0.463000													26	56					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111584888	111584888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:111584888G>A	ENST00000428084.1	-	10	1094	c.822C>T	c.(820-822)atC>atT	p.I274I	DOCK4_ENST00000437633.1_Silent_p.I274I|DOCK4_ENST00000476846.1_5'UTR			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	274					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TGTGCACGGTGATATAAATGT	0.433000													12	43					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21186092	21186092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21186092C>T	ENST00000377122.4	-	1	439	c.43G>A	c.(43-45)Gaa>Aaa	p.E15K	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377119.1_Missense_Mutation_p.E15K	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	15					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						atcttttcttcttcagtttca	0.333000													8	25					0	0	1	0	0
SPANXN1	494118	broad.mit.edu	37	X	144329145	144329145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:144329145G>A	ENST00000370493.3	+	1	798	c.39G>A	c.(37-39)agG>agA	p.R13R		NM_001009614.2	NP_001009614.1	Q5VSR9	SPXN1_HUMAN	SPANX family, member N1	13										endometrium(2)|kidney(2)|lung(8)|prostate(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGAAGAGGAAGAGCCCCT	0.463000													90	60					0	0	1	0	0
LIME1	54923	broad.mit.edu	37	20	62369176	62369176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62369176C>T	ENST00000309546.3	+	3	188	c.101C>T	c.(100-102)cCc>cTc	p.P34L	ZGPAT_ENST00000490623.1_3'UTR|LIME1_ENST00000490824.1_3'UTR	NM_017806.2	NP_060276.2			Lck interacting transmembrane adaptor 1											kidney(1)|large_intestine(1)|liver(1)	3	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					CCCCCAAGGCCCGAGGACGCT	0.766000													4	6					0	0	1	0	0
PDGFC	56034	broad.mit.edu	37	4	157689119	157689119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:157689119C>T	ENST00000502773.1	-	5	1217	c.727G>A	c.(727-729)Gag>Aag	p.E243K	PDGFC_ENST00000504672.1_5'UTR|PDGFC_ENST00000541126.1_Missense_Mutation_p.E80K|PDGFC_ENST00000542208.1_Missense_Mutation_p.E88K|PDGFC_ENST00000422544.2_Missense_Mutation_p.E243K	NM_016205.2	NP_057289.1	Q9NRA1	PDGFC_HUMAN	platelet derived growth factor C	243					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		CTTACCTCCTCTGTTAGAAGG	0.393000													67	146					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304276	10304276	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10304276C>T	ENST00000403437.2	-	26	3349	c.3254_splice	c.e26-1	p.K1085_splice	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1085					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CAAATTCTTTCCTTTAGACAG	0.333000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				20	30					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111997701	111997701	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111997701G>A	ENST00000305815.5	-	4	445	c.193C>T	c.(193-195)Caa>Taa	p.Q65*	SLC9C1_ENST00000487372.1_Nonsense_Mutation_p.Q65*|SLC9C1_ENST00000467397.1_5'UTR	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	65					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										GCGTATCTTTGGACCTAATAT	0.323000													37	100					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70818641	70818641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:70818641C>T	ENST00000358731.4	+	24	5515	c.5252C>T	c.(5251-5253)tCc>tTc	p.S1751F	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1751					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TGTGTAGGTTCCAAAGAGTCT	0.378000													26	74					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3675093	3675093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3675093G>A	ENST00000344754.4	-	12	3030	c.3031C>T	c.(3031-3033)Cct>Tct	p.P1011S	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.P1011S	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1011	Ig-like C2-type 10.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						TGGGCCGGAGGGTCACTGTCC	0.672000													6	18					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203025996	203025996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203025996C>T	ENST00000367240.2	+	18	2789	c.2262C>T	c.(2260-2262)atC>atT	p.I754I	PPFIA4_ENST00000447715.2_Silent_p.I753I|PPFIA4_ENST00000272198.6_Silent_p.I269I|PPFIA4_ENST00000295706.4_Silent_p.I269I|PPFIA4_ENST00000414050.2_Silent_p.I482I|PPFIA4_ENST00000599966.1_Silent_p.I269I			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	269					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						GCAAGGGCATCAAGTCGTCCA	0.617000													12	35					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	605215	605215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:605215C>T	ENST00000381578.1	+	6	1414	c.723C>T	c.(721-723)ttC>ttT	p.F241F	SHOX_ENST00000334060.3_Intron|SHOX_ENST00000554971.1_Silent_p.F241F|SHOX_ENST00000381575.1_Intron	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	241					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACCTGATGTTCCCCCCGCCGC	0.736000													3	5					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11725328	11725328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11725328G>A	ENST00000381486.2	+	8	1243	c.943G>A	c.(943-945)Ggg>Agg	p.G315R	GREB1_ENST00000234142.5_Missense_Mutation_p.G315R|GREB1_ENST00000263834.5_Missense_Mutation_p.G315R|GREB1_ENST00000381483.2_Missense_Mutation_p.G315R	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	315						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACGCCACAAAGGGTGGTCTCC	0.502000													15	26					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11052763	11052763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11052763G>A	ENST00000295082.1	+	1	701	c.211G>A	c.(211-213)Gac>Aac	p.D71N		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	71						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CGACGACTACGACCCCGGCAA	0.597000													18	34					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300558	88300558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88300558G>A	ENST00000418177.2	-	8	2660	c.2293C>T	c.(2293-2295)Cca>Tca	p.P765S	GRM5_ENST00000305447.4_Missense_Mutation_p.P765S|GRM5_ENST00000393297.1_Missense_Mutation_p.P765S|GRM5_ENST00000455756.2_Missense_Mutation_p.P765S|GRM5_ENST00000305432.5_Missense_Mutation_p.P765S			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	765					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AAGTTAGCTGGAACATTTCTG	0.438000													52	137					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456292	5456292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5456292C>T	ENST00000222033.4	+	1	867	c.790C>T	c.(790-792)Ctg>Ttg	p.L264L		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	264						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		TACCCTGGCCCTGGTCGTATC	0.677000													27	71					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167645876	167645876	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167645876C>T	ENST00000519204.1	+	22	4735	c.4617C>T	c.(4615-4617)acC>acT	p.T1539T	TENM2_ENST00000403607.2_Silent_p.T1484T|TENM2_ENST00000545108.1_Silent_p.T1659T|TENM2_ENST00000518659.1_Silent_p.T1660T|TENM2_ENST00000520394.1_Silent_p.T1421T					teneurin transmembrane protein 2																		TCACCCTCACCGTGGGCACCA	0.552000													29	141					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231115757	231115757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231115757C>T	ENST00000392045.3	+	10	1152	c.1038C>T	c.(1036-1038)tcC>tcT	p.S346S	SP140_ENST00000417495.3_Intron|SP140_ENST00000343805.6_Silent_p.S320S|SP140_ENST00000486687.2_Silent_p.S270S|SP140_ENST00000350136.5_Intron|SP140_ENST00000420434.3_Silent_p.S346S	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	346					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CCTCTAGCTCCCTAGCAAGAT	0.478000													19	43					0	0	1	0	0
SUSD4	55061	broad.mit.edu	37	1	223465938	223465938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:223465938C>T	ENST00000343846.3	-	2	837	c.204G>A	c.(202-204)agG>agA	p.R68R	SUSD4_ENST00000454695.2_5'UTR|SUSD4_ENST00000478605.1_5'UTR|SUSD4_ENST00000344029.6_Silent_p.R68R|SUSD4_ENST00000366878.4_Silent_p.R68R			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	68	Sushi 1.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		CGCTGGGGGTCCTGAAGCCAT	0.507000													25	80					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179595094	179595094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179595094G>A	ENST00000589042.1	-	62	18257	c.18033C>T	c.(18031-18033)ccC>ccT	p.P6011P	TTN_ENST00000342992.6_Silent_p.P4767P|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.P5694P	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5694	Ig-like 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAAGTAAGGGGGTTCTGAGG	0.353000													6	16					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16925942	16925942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16925942G>A	ENST00000552788.1	+	18	4497	c.4497G>A	c.(4495-4497)gaG>gaA	p.E1499E	NWD1_ENST00000524140.2_3'UTR|NWD1_ENST00000523826.1_Silent_p.E1293E|NWD1_ENST00000379808.3_3'UTR|NWD1_ENST00000339803.6_Silent_p.E1364E|NWD1_ENST00000549814.1_Silent_p.E1457E			Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1499							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGATCCGAGAGAATTTCCAGT	0.512000													31	66					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427393	119427393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119427393G>A	ENST00000369429.3	-	8	1780	c.1771C>T	c.(1771-1773)Cca>Tca	p.P591S	TBX15_ENST00000207157.3_Missense_Mutation_p.P485S			Q96SF7	TBX15_HUMAN	T-box 15	591						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GAGGAGCCTGGAACTGCCCCA	0.557000													29	88					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190805	209190805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:209190805C>T	ENST00000264380.4	+	20	3428	c.3270C>T	c.(3268-3270)ctC>ctT	p.L1090L		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1090					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						GGTCTCCTCTCCTCAATAAAG	0.448000													27	84					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124626255	124626255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124626255G>A	ENST00000278927.5	-	4	584	c.455C>T	c.(454-456)cCt>cTt	p.P152L	ESAM_ENST00000442070.2_Intron	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	152					blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		AGGAGCTGGAGGAACTGGGCA	0.597000													3	12					0	0	1	0	0
PROZ	8858	broad.mit.edu	37	13	113814419	113814419	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113814419G>A	ENST00000342783.4	+	3	235	c.228G>A	c.(226-228)ttG>ttA	p.L76L	PROZ_ENST00000375547.2_Silent_p.L54L	NM_001256134.1	NP_001243063.1	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma glycoprotein	54	Gla.				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity			NS(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(4)|prostate(2)|skin(2)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	AGGGAAACTTGGAAAAAGAAT	0.463000													68	167					0	0	1	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129042	248129042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248129042C>T	ENST00000366480.3	+	1	508	c.409C>T	c.(409-411)Cgc>Tgc	p.R137C	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTCTTATGATCGCTATGTAGC	0.438000													111	318					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167077760	167077760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167077760C>T	ENST00000392766.2	-	8	670	c.330G>A	c.(328-330)gtG>gtA	p.V110V	ZBBX_ENST00000307529.5_Silent_p.V110V|ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Silent_p.V81V|ZBBX_ENST00000392767.2_Silent_p.V110V|ZBBX_ENST00000455345.2_Silent_p.V110V	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	110						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CTGTTGGTTTCACTGGCTCTG	0.303000													17	37					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161007493	161007493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161007493G>A	ENST00000447678.1	-	26	4237	c.4117C>T	c.(4117-4119)Cct>Tct	p.P1373S	LPA_ENST00000316300.5_Missense_Mutation_p.P1373S	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3881	Kringle 12.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TCTTCAGAAGGAAGCTCTGTG	0.478000													36	45					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184103898	184103898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184103898C>T	ENST00000204604.1	+	15	2129	c.1883C>T	c.(1882-1884)tCc>tTc	p.S628F	CHRD_ENST00000348986.3_Missense_Mutation_p.S588F|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000545352.1_Missense_Mutation_p.S258F|CHRD_ENST00000450923.1_Missense_Mutation_p.S628F	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	628	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGCATGGCCTCCCTGATGATC	0.622000													29	76					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167814888	167814888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167814888G>A	ENST00000367848.1	-	21	3141	c.2644C>T	c.(2644-2646)Ccc>Tcc	p.P882S	ADCY10_ENST00000545172.1_Missense_Mutation_p.P821S|ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Missense_Mutation_p.P974S			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	974					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TGATGATAGGGAATGAAGTCC	0.448000													33	68					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120871407	120871407	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120871407G>A	ENST00000273666.6	+	8	1024	c.753_splice	c.e8+1	p.E251_splice	STXBP5L_ENST00000471454.1_Splice_Site_p.E251_splice|STXBP5L_ENST00000492541.1_Splice_Site_p.E251_splice|STXBP5L_ENST00000497029.1_Splice_Site_p.E251_splice|STXBP5L_ENST00000472879.1_Splice_Site_p.E251_splice	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	251					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ATTATGATGAGGTAAGTGATT	0.353000													27	54					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3730080	3730080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3730080C>T	ENST00000541714.2	+	4	675	c.213C>T	c.(211-213)tcC>tcT	p.S71S	TJP3_ENST00000262968.9_Silent_p.S90S|TJP3_ENST00000587686.1_Silent_p.S90S|TJP3_ENST00000589378.1_Silent_p.S80S|TJP3_ENST00000539908.2_Silent_p.S35S|TJP3_ENST00000382008.3_Silent_p.S71S	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	71	PDZ 1.					tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGCCACCTCCGCGTTTGCCA	0.597000													34	100					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82763915	82763915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82763915C>T	ENST00000423517.2	-	3	3288	c.2951G>A	c.(2950-2952)gGt>gAt	p.G984D	PCLO_ENST00000333891.8_Missense_Mutation_p.G984D	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	930					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGTGCTTGACCTGTGGATTT	0.512000													21	33					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123193527	123193527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123193527C>T	ENST00000264501.4	+	48	8786	c.8413C>T	c.(8413-8415)Cat>Tat	p.H2805Y	KIAA1109_ENST00000388738.3_Missense_Mutation_p.H2805Y|KIAA1109_ENST00000455637.1_Missense_Mutation_p.H2805Y			Q2LD37	K1109_HUMAN	KIAA1109	2805					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GAAGAGGATCCATGGCAGTTT	0.363000													18	56					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88584297	88584297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88584297C>T	ENST00000339673.6	+	6	1466	c.1367C>T	c.(1366-1368)tCt>tTt	p.S456F	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.S440F|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	456					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GACAGTGACTCTCAAGACAGC	0.522000													16	59					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141765585	141765585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141765585G>A	ENST00000475668.2	+	40	4778	c.4724G>A	c.(4723-4725)gGg>gAg	p.G1575E	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1575	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ATGCAGCTGGGGGCCTTTTAC	0.493000													18	44					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57478841	57478841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57478841C>T	ENST00000371100.4	+	5	2908	c.2356C>T	c.(2356-2358)Cct>Tct	p.P786S	GNAS_ENST00000265620.7_Missense_Mutation_p.P128S|GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000371085.3_Missense_Mutation_p.P143S|GNAS_ENST00000306090.10_Missense_Mutation_p.P129S|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371095.3_Missense_Mutation_p.P129S|GNAS_ENST00000313949.7_3'UTR|GNAS_ENST00000371102.4_Missense_Mutation_p.P772S|GNAS_ENST00000354359.7_Missense_Mutation_p.P144S	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	143					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CTTTGACTTCCCTCCCGTAAG	0.582000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			53	216					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109881406	109881406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109881406G>A	ENST00000310903.5	+	28	2834	c.2728G>A	c.(2728-2730)Gtg>Atg	p.V910M	MYO1H_ENST00000431443.2_Missense_Mutation_p.V920M			B4DNW6	B4DNW6_HUMAN	myosin IH	101						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						AGCTTACGTGGTGGAACTTGC	0.443000													10	20					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24561588	24561588	+	Silent	SNP	C	C	T	rs150284461		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24561588C>T	ENST00000398319.2	+	31	5386	c.5001C>T	c.(4999-5001)ctC>ctT	p.L1667L	CABIN1_ENST00000405822.2_Silent_p.L1588L|CABIN1_ENST00000263119.5_Silent_p.L1667L|CABIN1_ENST00000337989.7_Silent_p.L92L	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	1667					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TGAGCGAGCTCGCAGAGGTAT	0.612000													8	20					0	0	1	0	0
FHL5	9457	broad.mit.edu	37	6	97058463	97058463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:97058463G>A	ENST00000326771.2	+	6	900	c.520G>A	c.(520-522)Ggg>Agg	p.G174R	FHL5_ENST00000541107.1_Missense_Mutation_p.G174R	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	174	LIM zinc-binding 3.					nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		AACTTCAGGTGGGATAACATT	0.413000													64	103					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39798511	39798511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39798511C>T	ENST00000248668.4	-	2	2077	c.2078G>A	c.(2077-2079)gGa>gAa	p.G693E		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	693						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGCCGCGGCTCCCCCAGGAAC	0.721000													5	9					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17198950	17198950	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17198950C>T	ENST00000180173.5	-	6	688	c.654G>A	c.(652-654)gaG>gaA	p.E218E	MTMR7_ENST00000523571.1_5'UTR|MTMR7_ENST00000521857.1_Silent_p.E218E	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	218	Myotubularin phosphatase.						protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		TCTGCTCGTCCTCTAGGCACC	0.577000													7	40					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111570421	111570421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:111570421G>A	ENST00000261486.5	-	12	1273	c.997C>T	c.(997-999)Ctt>Ttt	p.L333F	RP11-526F3.1_ENST00000504004.1_RNA	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	333						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TGAATAGAAAGATCTCGGCTC	0.443000													52	121					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64756126	64756126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:64756126C>T	ENST00000536360.1	-	4	1315	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	168					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TTTAAAGGTTCGATAAAATAC	0.313000													22	128					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119923749	119923749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119923749G>A	ENST00000361035.4	+	3	363	c.80G>A	c.(79-81)cGa>cAa	p.R27Q	HAO2_ENST00000325945.3_Missense_Mutation_p.R14Q	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	14	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity	p.R14L(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		GCCCATGCGCGAGAGCAGCTG	0.468000													63	154					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185229332	185229332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185229332C>T	ENST00000296252.4	-	9	1389	c.1248G>A	c.(1246-1248)agG>agA	p.R416R	LIPH_ENST00000424591.2_Silent_p.R382R	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	416					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GGGCAAGGGACCTTAACTTCA	0.468000													34	69					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77327083	77327083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77327083G>A	ENST00000282849.5	-	20	3497	c.3079C>T	c.(3079-3081)Ccc>Tcc	p.P1027S		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	1027	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGGCTCTCGGGGAGGGTTTCT	0.572000													46	86					0	0	1	0	0
ODF3L2	284451	broad.mit.edu	37	19	474630	474630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:474630G>A	ENST00000315489.4	-	1	353	c.118C>T	c.(118-120)Ctg>Ttg	p.L40L	ODF3L2_ENST00000382696.3_Silent_p.L40L	NM_182577.2	NP_872383.1	Q3SX64	OD3L2_HUMAN	outer dense fiber of sperm tails 3-like 2	40										large_intestine(1)|lung(2)	3						CCGTTCTCCAGGGTGGCCGTC	0.672000													5	12					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127768553	127768553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:127768553C>T	ENST00000483725.3	-	5	1247	c.911G>A	c.(910-912)cGa>cAa	p.R304Q	SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	304							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		CCTTTTACTTCGACCCTCATG	0.433000													53	40					0	0	1	0	0
DDX41	51428	broad.mit.edu	37	5	176939611	176939611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176939611G>A	ENST00000507955.1	-	14	1958	c.1435C>T	c.(1435-1437)Cgg>Tgg	p.R479W		NM_016222.2	NP_057306.2	Q9UJV9	DDX41_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	479	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TTGCCCTCCCGGAATGCCTCG	0.597000													5	77					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95380460	95380460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95380460C>T	ENST00000371447.3	+	2	690	c.552C>T	c.(550-552)atC>atT	p.I184I		NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	184	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				CAACCCCGATCGTGGTGGGCA	0.443000													33	84					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93797595	93797595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93797595G>A	ENST00000315765.9	+	4	735	c.727G>A	c.(727-729)Gaa>Aaa	p.E243K		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	243	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GTACCTCAATGAAAATATCAA	0.398000													16	39					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17013509	17013509	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17013509C>T	ENST00000443236.1	-	35	4807	c.4776G>A	c.(4774-4776)gcG>gcA	p.A1592A		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1545						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GCTGATCGGCCGCTGGGTCAT	0.662000													11	41					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178410064	178410064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178410064G>A	ENST00000231188.5	-	9	2461	c.2283C>T	c.(2281-2283)ctC>ctT	p.L761L	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Silent_p.L761L	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	761					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		ACGTGACCATGAGCAGGAGGC	0.622000													24	74					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36884182	36884182	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36884182G>A	ENST00000301807.6	-	17	5326	c.3429C>T	c.(3427-3429)ttC>ttT	p.F1143F	TRANK1_ENST00000429976.2_Silent_p.F1693F|TRANK1_ENST00000428977.2_Silent_p.F1143F|TRANK1_ENST00000463984.1_5'UTR	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1693					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGGTCTTAACGAACATGCTAT	0.463000													28	12					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145427402	145427402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145427402C>T	ENST00000511217.1	+	5	1179	c.1127C>T	c.(1126-1128)tCc>tTc	p.S376F	SH3RF2_ENST00000359120.4_Missense_Mutation_p.S376F			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	376							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGCCTGGCTCCCAGCAACAC	0.537000													20	54					0	0	1	0	0
CD247	919	broad.mit.edu	37	1	167487664	167487664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167487664C>T	ENST00000392122.3	-	1	183	c.39G>A	c.(37-39)caG>caA	p.Q13Q	CD247_ENST00000362089.5_Silent_p.Q13Q|CD247_ENST00000483825.1_5'UTR	NM_000734.3|NM_198053.2	NP_000725.1|NP_932170.1	P20963	CD3Z_HUMAN	CD247 molecule	13					interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(543;0.236)			GCAACTGTGCCTGCAGGATGG	0.597000													6	71					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120349057	120349057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120349057C>T	ENST00000397843.2	+	37	3891	c.3725C>T	c.(3724-3726)cCt>cTt	p.P1242L	ARHGEF12_ENST00000532993.1_Missense_Mutation_p.P1139L|ARHGEF12_ENST00000356641.3_Missense_Mutation_p.P1223L	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1242					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TCACACCTGCCTGTCTCAGAA	0.398000			T	MLL	AML								35	73					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78433820	78433820	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78433820G>A	ENST00000278550.7	-	24	4155	c.3693C>T	c.(3691-3693)gcC>gcT	p.A1231A		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GGGCCACTGGGGCCAGGAGCT	0.577000													11	90					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65180988	65180988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:65180988G>A	ENST00000310045.7	-	2	2361	c.888C>T	c.(886-888)tcC>tcT	p.S296S	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	286						integral to membrane	isomerase activity|sulfotransferase activity	p.S296S(1)		NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				ACTGTGTGACGGATTTAGCTG	0.388000													53	90					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35366948	35366948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35366948C>T	ENST00000378495.3	+	11	1394	c.1172C>T	c.(1171-1173)cCa>cTa	p.P391L	UNC13B_ENST00000378496.4_Missense_Mutation_p.P391L|UNC13B_ENST00000396787.1_Missense_Mutation_p.P403L	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	391					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TTAAAGATTCCAGATGATGGT	0.448000													12	55					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47299583	47299583	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47299583G>A	ENST00000225941.1	+	7	1431	c.933G>A	c.(931-933)gaG>gaA	p.E311E	ABI3_ENST00000419580.2_Silent_p.E305E	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	311	SH3.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			CATACTTGGAGAAAGGTACCT	0.592000										HNSCC(55;0.14)			27	73					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926778	130926778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130926778C>T	ENST00000261655.4	-	8	1231	c.1068G>A	c.(1066-1068)aaG>aaA	p.K356K	RIMBP2_ENST00000536002.1_Silent_p.K264K|RIMBP2_ENST00000535703.1_Silent_p.K264K	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	356	Fibronectin type-III 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CCATGTTGAGCTTCTCGATGA	0.612000													26	63					0	0	1	0	0
FAM74A3	728495	broad.mit.edu	37	9	40715848	40715848	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:40715848G>A	ENST00000604146.1	+	0	187					NR_026801.1															endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACCCAGAGAAGATGTGGAGGG	0.567000													3	3					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954625	70954625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70954625C>T	ENST00000393567.2	-	46	7804	c.7654G>A	c.(7654-7656)Ggg>Agg	p.G2552R		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2552										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				tcctcctccccttccccctcc	0.647000													3	7					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575497	136575497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136575497C>T	ENST00000264162.2	-	6	1131	c.1121G>A	c.(1120-1122)aGg>aAg	p.R374K		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	374	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAAGGCATCCCTTTCCGCCCT	0.602000													47	135					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138453099	138453099	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138453099T>C	ENST00000344876.4	-	1	530	c.144A>G	c.(142-144)tcA>tcG	p.S48S	PCDH18_ENST00000412923.2_Silent_p.S48S|PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	48	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S48S(1)		NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					CCACATCCTCTGATAGTCTTG	0.413000													33	85					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124757009	124757009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124757009G>A	ENST00000306534.3	-	15	2784	c.2299C>T	c.(2299-2301)Ctc>Ttc	p.L767F	RP11-664I21.5_ENST00000524453.1_RNA|ROBO4_ENST00000533054.1_Missense_Mutation_p.L622F	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	767	Pro/Ser-rich.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		GGGCCAGAGAGGGAAGAGGCC	0.672000													11	47					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247582117	247582117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247582117C>T	ENST00000366497.2	+	2	801	c.21C>T	c.(19-21)cgC>cgT	p.R7R	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Silent_p.R7R|NLRP3_ENST00000336119.3_Silent_p.R7R|NLRP3_ENST00000348069.2_Silent_p.R7R|NLRP3_ENST00000391828.3_Silent_p.R7R|NLRP3_ENST00000391827.2_Silent_p.R7R	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	7	DAPIN.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAAGCACCCGCTGCAAGCTGG	0.537000													13	44					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70007795	70007795	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70007795G>A	ENST00000355303.5	+	18	2153	c.1848G>A	c.(1846-1848)gtG>gtA	p.V616V	ANO1_ENST00000538023.1_Silent_p.V616V|ANO1_ENST00000531349.1_Silent_p.V325V|ANO1_ENST00000316296.5_Silent_p.V558V|ANO1_ENST00000398543.2_Silent_p.V470V|ANO1_ENST00000530676.1_Silent_p.V470V	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	616					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TGAAGTTTGTGAATTCCTACA	0.532000													44	139					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128362828	128362828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128362828G>A	ENST00000262462.4	+	7	2268	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K	SLC27A6_ENST00000395266.1_Missense_Mutation_p.E420K|SLC27A6_ENST00000506176.1_Missense_Mutation_p.E420K			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	420					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TCTTGCAGGAGAACCTGGACT	0.383000													37	84					0	0	1	0	0
KLRC4	8302	broad.mit.edu	37	12	10560278	10560278	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10560278G>A	ENST00000309384.1	-	4	632	c.451C>T	c.(451-453)Cga>Tga	p.R151*	KLRC4-KLRK1_ENST00000539300.1_Missense_Mutation_p.S142L	NM_013431.2	NP_038459.1	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C, member 4	151					cellular defense response	integral to membrane	binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	5						AGAGTTCTTCGAAGCACAGGC	0.363000													92	215					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170498183	170498183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:170498183G>A	ENST00000439128.2	-	11	1556	c.916C>T	c.(916-918)Cag>Tag	p.Q306*	NEK1_ENST00000511633.1_Nonsense_Mutation_p.Q306*|NEK1_ENST00000510533.1_Nonsense_Mutation_p.Q306*|NEK1_ENST00000507142.1_Nonsense_Mutation_p.Q306*|NEK1_ENST00000512193.1_Nonsense_Mutation_p.Q306*	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	306					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		GTAATTTTCTGAGCAGGCATA	0.328000													17	41					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117922301	117922301	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117922301C>T	ENST00000425217.1	-	16	2337	c.2283G>A	c.(2281-2283)aaG>aaA	p.K761K	KSR2_ENST00000302438.5_3'UTR|KSR2_ENST00000339824.5_Silent_p.K790K	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	790	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGAAGACGTTCTTTGACTTGA	0.527000													10	27					0	0	1	0	0
C1orf158	93190	broad.mit.edu	37	1	12815753	12815753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12815753G>A	ENST00000288048.5	+	2	431	c.215G>A	c.(214-216)aGg>aAg	p.R72K	C1orf158_ENST00000376210.3_Intron	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	72										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TATGGGAAGAGGAAAGTTGAG	0.527000													18	36					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413453	72413453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72413453C>T	ENST00000395270.1	+	14	3167	c.2126C>T	c.(2125-2127)gCc>gTc	p.A709V	POM121_ENST00000257622.4_Missense_Mutation_p.A709V|POM121_ENST00000434423.2_Missense_Mutation_p.A974V|POM121_ENST00000358357.3_Missense_Mutation_p.A709V|POM121_ENST00000446813.1_Missense_Mutation_p.A709V	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	974	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				GCATTTGGGGCCGCTGAGGGG	0.652000													17	53					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36945041	36945041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36945041G>A	ENST00000373103.1	-	3	604	c.57C>T	c.(55-57)ctC>ctT	p.L19L	CSF3R_ENST00000440588.2_Silent_p.L19L|CSF3R_ENST00000331941.5_Silent_p.L19L|CSF3R_ENST00000373106.1_Silent_p.L19L|CSF3R_ENST00000361632.4_Silent_p.L19L|CSF3R_ENST00000373104.1_Silent_p.L19L|CSF3R_ENST00000418048.2_Silent_p.L19L|CSF3R_ENST00000338937.5_Silent_p.L19L	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	19					cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CACTTCCGGGGAGCAGCAGGA	0.547000													20	50					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31914248	31914248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31914248G>A	ENST00000456570.1	+	14	1724	c.1669G>A	c.(1669-1671)Ggc>Agc	p.G557S	CFB_ENST00000425368.2_Missense_Mutation_p.G55S|CFB_ENST00000477310.1_Intron|CFB_ENST00000556679.1_Missense_Mutation_p.G557S			P00751	CFAB_HUMAN	complement factor B	55	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TCTCCAAGAGGGCCAGGCACT	0.602000													28	61					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54850343	54850343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54850343G>A	ENST00000291759.4	-	1	78	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	8						integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		AAGAAGAGCAGGCTTGTGAGA	0.562000													5	89					0	0	1	0	0
CD38	952	broad.mit.edu	37	4	15826536	15826536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:15826536C>T	ENST00000226279.2	+	3	533	c.396C>T	c.(394-396)gcC>gcT	p.A132A		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	132					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						AAGATCTGGCCCATCAGTTCA	0.418000													18	76					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22182404	22182404	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22182404G>A	ENST00000374695.3	-	45	5656	c.5575_splice	c.e45-1	p.A1859_splice		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1859	Ig-like C2-type 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGGTGCCCGAGGCTGACAAGG	0.632000													15	33					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138745818	138745818	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138745818G>T	ENST00000242351.5	-	9	2376	c.2060C>A	c.(2059-2061)cCt>cAt	p.P687H	ZC3HAV1_ENST00000471652.1_Missense_Mutation_p.P687H|ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.P809H	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	687					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						ATACCACTGAGGCACAAATGT	0.433000													19	172					1.96292e-10	1.9709e-10	1	1	0
SLC44A3	126969	broad.mit.edu	37	1	95290159	95290159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:95290159C>T	ENST00000271227.6	+	3	348	c.246C>T	c.(244-246)gcC>gcT	p.A82A	SLC44A3_ENST00000527077.1_Silent_p.A46A|SLC44A3_ENST00000529450.1_Silent_p.A82A|SLC44A3_ENST00000532427.1_Silent_p.A34A|SLC44A3_ENST00000467909.1_Silent_p.A34A|SLC44A3_ENST00000446120.2_Silent_p.A46A	NM_001114106.2|NM_001258340.1|NM_001258341.1	NP_001107578.1|NP_001245269.1|NP_001245270.1	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3	82						integral to membrane|plasma membrane	choline transmembrane transporter activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|prostate(2)|stomach(1)|urinary_tract(1)	23		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	TGGAAGGGGCCCCTCTTTCAG	0.488000													19	124					0	0	1	0	0
IKBKE	9641	broad.mit.edu	37	1	206653844	206653844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206653844C>T	ENST00000367120.3	+	13	1768	c.1395C>T	c.(1393-1395)ctC>ctT	p.L465L	IKBKE_ENST00000462698.1_3'UTR|IKBKE_ENST00000537984.1_Silent_p.L380L	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	465					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					GGACATCCCTCCTCTACCTCA	0.612000													9	21					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187535466	187535466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187535466G>A	ENST00000441802.2	-	12	9317	c.9108C>T	c.(9106-9108)gtC>gtT	p.V3036V		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3036	Cadherin 28.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTCCAGGAAGGACGTCTTCAG	0.388000										HNSCC(5;0.00058)			28	58					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479481	156479481	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156479481C>T	ENST00000339252.3	-	3	1096	c.564G>A	c.(562-564)acG>acA	p.T188T	HAVCR1_ENST00000425854.1_Silent_p.T188T|HAVCR1_ENST00000544197.1_Silent_p.T188T|HAVCR1_ENST00000522693.1_Silent_p.T188T|HAVCR1_ENST00000523175.1_Silent_p.T188T	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	183	11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].|Thr-rich.				interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGGAACGCTCGTTGTCGTTG	0.473000													171	448					0	0	1	0	0
EXOSC7	23016	broad.mit.edu	37	3	45030635	45030635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45030635G>A	ENST00000265564.7	+	2	109	c.61G>A	c.(61-63)Gac>Aac	p.D21N	EXOSC7_ENST00000461361.1_3'UTR	NM_015004.3	NP_055819.2	Q15024	EXOS7_HUMAN	exosome component 7	21					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding			endometrium(3)|large_intestine(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		CACCTAGGAAGACCTCCGTGT	0.507000													11	35					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130919328	130919328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130919328C>T	ENST00000261655.4	-	11	2316	c.2153G>A	c.(2152-2154)aGg>aAg	p.R718K	RIMBP2_ENST00000536002.1_Missense_Mutation_p.R626K|RIMBP2_ENST00000535703.1_Missense_Mutation_p.R626K	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	718						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CGAGGCGCCCCTCCTCTTGAA	0.627000													54	81					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175063304	175063304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175063304G>A	ENST00000239462.4	+	7	1616	c.1503G>A	c.(1501-1503)ctG>ctA	p.L501L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	501	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGACGGGCCTGAAGCCAGGAG	0.547000													18	34					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	328088	328088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:328088C>T	ENST00000432829.2	+	9	1073	c.757C>T	c.(757-759)Cct>Tct	p.P253S	DOCK8_ENST00000453981.1_Missense_Mutation_p.P321S|DOCK8_ENST00000469391.1_Missense_Mutation_p.P253S	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	321					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AGCTCACACGCCTTCAGTGGC	0.458000													7	59					0	0	1	0	0
GREM2	64388	broad.mit.edu	37	1	240656745	240656745	+	Silent	SNP	G	G	A	rs17857321		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240656745G>A	ENST00000318160.4	-	2	297	c.31C>T	c.(31-33)Ctg>Ttg	p.L11L		NM_022469.3	NP_071914.3	Q9H772	GREM2_HUMAN	gremlin 2, DAN family BMP antagonist	11				L -> M (in Ref. 3; AAH46632).	BMP signaling pathway	extracellular space	cytokine activity			endometrium(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	10		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			ACCGCCACCAGGAACAAGGAC	0.582000													3	15					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198949941	198949941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:198949941G>A	ENST00000428675.1	+	2	2098	c.1700G>A	c.(1699-1701)aGg>aAg	p.R567K	PLCL1_ENST00000437704.2_Missense_Mutation_p.R469K	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	567	Interaction with GABA A beta subunit (By similarity).				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	ATGTCTCGAAGGATGTCGGTA	0.393000													28	92					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153030042	153030042	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153030042G>A	ENST00000285900.5	+	4	956	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K	GRIA1_ENST00000518783.1_Missense_Mutation_p.E215K|GRIA1_ENST00000521843.2_Missense_Mutation_p.E136K|GRIA1_ENST00000340592.5_Missense_Mutation_p.E205K|GRIA1_ENST00000448073.4_Missense_Mutation_p.E215K|GRIA1_ENST00000518862.1_3'UTR|GRIA1_ENST00000518142.1_Missense_Mutation_p.E125K	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	205					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGTGGACTGTGAATCAGAACG	0.532000													17	47					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111398054	111398054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111398054G>A	ENST00000265162.5	+	1	826	c.484G>A	c.(484-486)Gag>Aag	p.E162K		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	162					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GAGGTGTTTCGAGTACAAAAA	0.627000													54	142					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34040696	34040696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34040696G>A	ENST00000389232.4	+	55	8234	c.8164G>A	c.(8164-8166)Gac>Aac	p.D2722N	RYR3_ENST00000415757.3_Missense_Mutation_p.D2722N	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2722	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGCTCCCCTCGACCTCTCAAA	0.517000													9	17					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231373	21231373	+	Silent	SNP	G	G	A	rs149734450		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21231373G>A	ENST00000233242.1	-	26	8494	c.8367C>T	c.(8365-8367)atC>atT	p.I2789I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2789					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGAAGCTGCGATACCTGCTT	0.413000													66	121					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33597733	33597733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33597733C>T	ENST00000170564.2	+	10	1527	c.1213C>T	c.(1213-1215)Cca>Tca	p.P405S		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	405						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					AACGCCTGACCCAGGGACACA	0.522000													13	69					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31917963	31917963	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:31917963G>A	ENST00000396556.2	-	3	621	c.499C>T	c.(499-501)Cga>Tga	p.R167*	OSBPL10_ENST00000438237.2_Nonsense_Mutation_p.R167*	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	167	PH.				lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		GCACAAGCTCGAAGCTGAGTC	0.418000													21	45					0	0	1	0	0
PNP	4860	broad.mit.edu	37	14	20943236	20943236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20943236C>T	ENST00000361505.5	+	5	623	c.477C>T	c.(475-477)ttC>ttT	p.F159F	RP11-203M5.8_ENST00000554678.1_lincRNA	NM_000270.3	NP_000261.2	P00491	PNPH_HUMAN	purine nucleoside phosphorylase	159					immune response|inosine catabolic process|interleukin-2 secretion|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide riboside catabolic process|positive regulation of alpha-beta T cell differentiation|positive regulation of T cell proliferation|purine base metabolic process|purine nucleotide catabolic process|purine-containing compound salvage|response to drug|urate biosynthetic process	cytoskeleton|cytosol	drug binding|nucleoside binding|phosphate binding|purine base binding|purine-nucleoside phosphorylase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|stomach(2)	10					Aciclovir(DB00787)|Cladribine(DB00242)|Mercaptopurine(DB01033)	GAGATCGTTTCCCTGCCATGT	0.473000													18	36					0	0	1	0	0
FAM129C	199786	broad.mit.edu	37	19	17660315	17660315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17660315C>T	ENST00000335393.4	+	15	1960	c.1822C>T	c.(1822-1824)Cca>Tca	p.P608S	FAM129C_ENST00000599164.1_Missense_Mutation_p.P577S|FAM129C_ENST00000600871.1_Intron|FAM129C_ENST00000352727.3_Missense_Mutation_p.P572S|FAM129C_ENST00000332386.5_Missense_Mutation_p.P608S|FAM129C_ENST00000601861.1_Missense_Mutation_p.P577S|FAM129C_ENST00000595684.1_Missense_Mutation_p.P608S|FAM129C_ENST00000599124.1_Missense_Mutation_p.P541S|FAM129C_ENST00000449408.2_Missense_Mutation_p.P334S	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	608										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						CTTGGAGGTCCCATGGGAACA	0.552000													32	108					0	0	1	0	0
MIR422A	494334	broad.mit.edu	37	15	64163163	64163163	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:64163163G>A	ENST00000362286.1	-	0	55					NR_029944.1																						gggacagagagcccatctgca	0.547000													8	143					0	0	1	0	0
MGLL	11343	broad.mit.edu	37	3	127454584	127454584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127454584C>T	ENST00000398101.3	-	1	616	c.118G>A	c.(118-120)Ggg>Agg	p.G40R	MGLL_ENST00000265052.5_Intron|MGLL_ENST00000453507.2_Intron|MGLL_ENST00000434178.2_Intron|MGLL_ENST00000398104.1_Intron			Q99685	MGLL_HUMAN	monoglyceride lipase	0					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6						TGCTCGCTCCCCGCCTTCTCC	0.493000													35	108					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113138932	113138932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113138932G>A	ENST00000393845.2	-	5	568	c.502C>T	c.(502-504)Ctg>Ttg	p.L168L	WDR52-AS1_ENST00000473329.1_RNA|WDR52-AS1_ENST00000498480.1_RNA|WDR52_ENST00000295868.2_Silent_p.L168L	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	168										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						TTCAAATTCAGAAAGATCAGT	0.428000													10	41					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032327	30032327	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30032327C>T	ENST00000328224.6	-	2	3132	c.1899G>A	c.(1897-1899)ggG>ggA	p.G633G		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	633						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CACTGTCATCCCCCTTTCCCT	0.478000													31	135					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39903468	39903468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:39903468C>T	ENST00000564288.1	+	71	18785	c.18008C>T	c.(18007-18009)cCt>cTt	p.P6003L	MACF1_ENST00000289893.4_Missense_Mutation_p.P4446L|MACF1_ENST00000567887.1_Missense_Mutation_p.P6040L|MACF1_ENST00000361689.2_Missense_Mutation_p.P3944L|MACF1_ENST00000539005.1_Missense_Mutation_p.P3814L|MACF1_ENST00000372915.3_Missense_Mutation_p.P5902L|MACF1_ENST00000317713.7_Missense_Mutation_p.P3944L|MACF1_ENST00000545844.1_Missense_Mutation_p.P3944L			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	6015					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAAATTGAGCCTATGTTGGAG	0.423000													41	118					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72862289	72862289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72862289G>A	ENST00000455107.2	-	6	755	c.339C>T	c.(337-339)ttC>ttT	p.F113F	FDXR_ENST00000582944.1_Silent_p.F149F|FDXR_ENST00000544854.1_Silent_p.F105F|FDXR_ENST00000442102.2_Silent_p.F200F|FDXR_ENST00000413947.2_Silent_p.F188F|FDXR_ENST00000293195.5_Silent_p.F157F|FDXR_ENST00000581530.1_Silent_p.F157F|FDXR_ENST00000420580.2_Silent_p.F117F|FDXR_ENST00000583917.1_Silent_p.F158F|FDXR_ENST00000581969.1_5'UTR			P22570	ADRO_HUMAN	ferredoxin reductase	157					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					ACCAGCCCACGAAGGCCCGGG	0.652000													11	114					0	0	1	0	0
GPT2	84706	broad.mit.edu	37	16	46943652	46943652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:46943652C>T	ENST00000440783.2	+	6	998	c.333C>T	c.(331-333)atC>atT	p.I111I	GPT2_ENST00000340124.4_Silent_p.I211I	NM_001142466.1	NP_001135938.1	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase (alanine aminotransferase) 2	211					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding	p.I211I(1)		NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GTGTGATGATCCCCATCCCAC	0.537000													23	73					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35832298	35832298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35832298C>T	ENST00000085219.5	+	8	1626	c.1560C>T	c.(1558-1560)caC>caT	p.H520H	CD22_ENST00000419549.2_Silent_p.H348H|CD22_ENST00000341773.6_Silent_p.H343H|CD22_ENST00000536635.2_Silent_p.H432H|CD22_ENST00000270311.6_Silent_p.H400H|CD22_ENST00000544992.2_Silent_p.H520H|CD22_ENST00000594250.1_Silent_p.H343H	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	520	Ig-like C2-type 5.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CCGAGATTCACTCTGGAAACT	0.552000													29	43					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106924104	106924104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106924104C>T	ENST00000369701.3	+	12	2003	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	592						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TTGGTGTGTTCATCTCCTCCG	0.438000													24	49					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385622	33385622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33385622G>A	ENST00000541274.1	-	5	822	c.373C>T	c.(373-375)Cct>Tct	p.P125S	AQP7_ENST00000377425.4_Intron|AQP7_ENST00000539936.1_Silent_p.F256F|AQP7_ENST00000537089.1_Silent_p.F164F			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		AAACTCAAAGGAATGGGCCTG	0.627000													18	67					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19483433	19483433	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19483433G>A	ENST00000396229.2	+	11	2555	c.1806G>A	c.(1804-1806)caG>caA	p.Q602Q	TMC5_ENST00000542583.2_Silent_p.Q602Q|TMC5_ENST00000564959.1_Silent_p.Q285Q|TMC5_ENST00000561503.1_Silent_p.Q243Q|TMC5_ENST00000219821.5_Silent_p.Q356Q|TMC5_ENST00000541464.1_Intron|TMC5_ENST00000381414.4_Silent_p.Q602Q	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	602						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AGCTCCGTCAGGAGAATTCCA	0.527000													24	110					0	0	1	0	0
CLMN	79789	broad.mit.edu	37	14	95670166	95670166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95670166G>A	ENST00000298912.4	-	9	1633	c.1520C>T	c.(1519-1521)tCc>tTc	p.S507F		NM_024734.3	NP_079010.2	Q96JQ2	CLMN_HUMAN	calmin (calponin-like, transmembrane)	507						integral to membrane	actin binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(17)|prostate(3)|skin(3)	44				Epithelial(152;0.193)		ACCATTACAGGAAGAAGACTG	0.468000													15	44					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56138249	56138249	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56138249G>A	ENST00000319441.4	+	5	940	c.776G>A	c.(775-777)gGg>gAg	p.G259E	PCK1_ENST00000535860.1_Missense_Mutation_p.G127E|PCK1_ENST00000543666.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	259					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			AAGGAGGAAGGGTGGCTGGCA	0.597000													32	64					0	0	1	0	0
SLC25A12	8604	broad.mit.edu	37	2	172644360	172644360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:172644360G>A	ENST00000422440.2	-	16	1720	c.1683C>T	c.(1681-1683)atC>atT	p.I561I	SLC25A12_ENST00000392592.4_Silent_p.I454I	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	561					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	TGAAACAGTCGATGACACCAC	0.577000													25	58					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76472668	76472668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:76472668C>T	ENST00000396423.2	+	9	1307	c.1183C>T	c.(1183-1185)Ccc>Tcc	p.P395S	HNF4G_ENST00000354370.1_Missense_Mutation_p.P358S	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	358					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ACTTTTAGGTCCCATGTCAAC	0.393000													11	42					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976196	20976196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20976196C>T	ENST00000261383.3	-	53	9009	c.9010G>A	c.(9010-9012)Gga>Aga	p.G3004R	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3004					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCCACAGTTCCTGAGGACAGC	0.537000													23	58					0	0	1	0	0
CDKN2AIP	55602	broad.mit.edu	37	4	184366211	184366211	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:184366211C>T	ENST00000504169.1	+	1	468	c.261C>T	c.(259-261)ttC>ttT	p.F87F	CDKN2AIP_ENST00000302350.4_Silent_p.F87F|CDKN2AIP_ENST00000510928.1_Silent_p.F87F	NM_017632.2	NP_060102.1	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	87					negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(1)	6		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		ACCACGTCTTCCTCGGGTGCC	0.687000													30	77					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115439652	115439652	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:115439652G>A	ENST00000393780.3	+	4	1216	c.748G>A	c.(748-750)Gaa>Aaa	p.E250K	GAP43_ENST00000305124.6_Missense_Mutation_p.E214K	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	214					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		AGCTGTAGATGAAACCAAACC	0.433000													112	270					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89381953	89381953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89381953G>A	ENST00000439576.2	+	3	504	c.130G>A	c.(130-132)Ggg>Agg	p.G44R	ACAN_ENST00000558207.1_Missense_Mutation_p.G44R|ACAN_ENST00000559004.1_Missense_Mutation_p.G44R|ACAN_ENST00000561243.1_Missense_Mutation_p.G44R|ACAN_ENST00000352105.7_Missense_Mutation_p.G44R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	44					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGTCCTCCTGGGGACCTCCCT	0.617000													83	81					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17699326	17699326	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:17699326G>A	ENST00000399080.2	-	1	380	c.357C>T	c.(355-357)ccC>ccT	p.P119P		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	119										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GACTTTGTGAGGGGGGAGACT	0.478000													16	66					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114111043	114111043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:114111043G>A	ENST00000297405.5	-	5	1103	c.859C>T	c.(859-861)Caa>Taa	p.Q287*	CSMD3_ENST00000352409.3_Nonsense_Mutation_p.Q287*|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.Q247*|CSMD3_ENST00000455883.2_Nonsense_Mutation_p.Q287*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	287	CUB 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCTTCCATTTGAAAATCAGTA	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	56					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165667	172165667	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172165667G>A	ENST00000241256.2	-	1	579	c.537C>T	c.(535-537)ttC>ttT	p.F179F	GHSR_ENST00000427970.1_Silent_p.F179F	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	179					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CGACTAGCACGAAGATGGGCC	0.662000													22	51					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50552915	50552915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50552915C>T	ENST00000262794.5	+	7	1073	c.990C>T	c.(988-990)ccC>ccT	p.P330P	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000540615.1_Silent_p.P310P|MOV10L1_ENST00000395858.3_Silent_p.P330P|MOV10L1_ENST00000545383.1_Silent_p.P330P	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	330					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGATGTGCCCCGTGGTATCTT	0.383000													20	78					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9014622	9014622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9014622C>T	ENST00000397910.4	-	31	38556	c.38353G>A	c.(38353-38355)Gag>Aag	p.E12785K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12787	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATAGCTGCTCCCTGTCCACT	0.572000													32	113					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238287447	238287447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238287447C>T	ENST00000295550.4	-	6	2781	c.2329G>A	c.(2329-2331)Gga>Aga	p.G777R	COL6A3_ENST00000392004.3_Missense_Mutation_p.G571R|COL6A3_ENST00000409809.1_Missense_Mutation_p.G571R|COL6A3_ENST00000392003.2_Missense_Mutation_p.G370R|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000346358.4_Intron|COL6A3_ENST00000353578.4_Missense_Mutation_p.G571R|COL6A3_ENST00000347401.3_Missense_Mutation_p.G576R	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	777	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGGCTAGCTCCCACACAAAAA	0.552000													8	28					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171520744	171520744	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:171520744G>C	ENST00000176763.5	-	9	1569	c.1226C>G	c.(1225-1227)cCc>cGc	p.P409R		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	409							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTTCCGCAGGGGCACAGGCAC	0.627000													10	56					0	0	1	0	0
TRAV1-2	28692	broad.mit.edu	37	14	22111137	22111137	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22111137C>T	ENST00000390423.2	+	0	29																											CTTCTGCAGACTCCAATGGCT	0.507000													6	25					0	0	1	0	0
SNPH	9751	broad.mit.edu	37	20	1276964	1276964	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1276964C>T	ENST00000381867.1	+	4	723	c.81C>T	c.(79-81)tcC>tcT	p.S27S	RAD21L1_ENST00000402452.1_Intron|SNPH_ENST00000381873.3_Intron|RAD21L1_ENST00000381882.2_Intron			O15079	SNPH_HUMAN	syntaphilin	0					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			endometrium(2)|large_intestine(4)|lung(10)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GCCCTCTCTCCTCAGCCCCCG	0.677000													4	25					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116720701	116720701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116720701C>T	ENST00000331677.3	+	3	732	c.288C>T	c.(286-288)gcC>gcT	p.A96A	DSE_ENST00000540275.1_3'UTR|DSE_ENST00000359564.2_Silent_p.A96A|DSE_ENST00000537543.1_Silent_p.A115A|DSE_ENST00000452085.3_Silent_p.A96A			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	96					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		ACTACAGTGCCCGCTGGAATG	0.547000													20	19					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53515095	53515095	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53515095G>A	ENST00000301466.3	+	12	1206	c.1146G>A	c.(1144-1146)tgG>tgA	p.W382*		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	382					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						AGGACTGGTGGAACTCAACGT	0.592000													23	46					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41476198	41476198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41476198G>A	ENST00000314992.5	-	10	1666	c.1476C>T	c.(1474-1476)tcC>tcT	p.S492S	EXD1_ENST00000458580.2_Silent_p.S550S	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	492					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						GAGGGAGTGTGGAAACCACAG	0.443000													35	93					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171258191	171258191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171258191G>A	ENST00000334231.6	+	18	2146	c.2146G>A	c.(2146-2148)Gaa>Aaa	p.E716K	MYO3B_ENST00000408978.4_Missense_Mutation_p.E707K|MYO3B_ENST00000409044.3_Missense_Mutation_p.E707K|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	707	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity	p.E707K(1)		breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GCAGCCAGACGAAAACATATG	0.527000													13	34					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17418749	17418749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17418749C>T	ENST00000302539.4	-	32	4107	c.3982G>A	c.(3982-3984)Ggg>Agg	p.G1328R	ABCC8_ENST00000389817.3_Missense_Mutation_p.G1327R	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1327					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCCAGGAGCCCCTCGTAGCTC	0.637000													29	156					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374936	27374936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27374936C>T	ENST00000395762.2	+	11	2522	c.2263C>T	c.(2263-2265)Cct>Tct	p.P755S	IL4R_ENST00000380922.3_Missense_Mutation_p.P740S|IL4R_ENST00000170630.2_Missense_Mutation_p.P755S|IL4R_ENST00000543915.2_Missense_Mutation_p.P755S	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	755					immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GTCCTCGCCCCCTACAACCCC	0.657000													4	48					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074222	9074222	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9074222G>A	ENST00000397910.4	-	3	13427	c.13224C>T	c.(13222-13224)acC>acT	p.T4408T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4410	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTAAGGCATGGTTGATGTGT	0.473000													38	136					0	0	1	0	0
IGHG4	3503	broad.mit.edu	37	14	106091547	106091547	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106091547C>T	ENST00000390543.2	-	0	346																											TGATGGTCCCCCCAGGAACTC	0.627000													26	54					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58980192	58980192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58980192C>T	ENST00000361050.3	-	1	232	c.147G>A	c.(145-147)ggG>ggA	p.G49G		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	49	MACPF.					integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				TGTCCCAGCCCCCTCCAGGTA	0.498000													71	158					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15053097	15053097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15053097C>T	ENST00000248072.3	+	1	797	c.797C>T	c.(796-798)cCt>cTt	p.P266L		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					GTTACACCACCTTCTAGGACA	0.537000													49	112					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120732746	120732746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120732746C>T	ENST00000527524.2	+	9	1110	c.823C>T	c.(823-825)Cat>Tat	p.H275Y	GRIK4_ENST00000438375.2_Missense_Mutation_p.H275Y			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	275					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CAACCAATCCCATGCTTTCTT	0.522000													89	211					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37299050	37299050	+	Missense_Mutation	SNP	G	G	A	rs146473381		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:37299050G>A	ENST00000231498.3	-	32	3916	c.3713C>T	c.(3712-3714)tCg>tTg	p.S1238L	NUP155_ENST00000381843.2_Missense_Mutation_p.S1179L|NUP155_ENST00000513532.1_Missense_Mutation_p.S1174L|NUP155_ENST00000502533.1_5'UTR	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	1238					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATTCTATCCGAGGAGCTCAA	0.373000													5	50					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7691433	7691433	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7691433C>T	ENST00000572933.1	+	44	8231	c.6771C>T	c.(6769-6771)ttC>ttT	p.F2257F	DNAH2_ENST00000389173.2_Silent_p.F2257F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2257	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AACGCATGTTCGAAAAGCTCA	0.542000													10	27					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119216622	119216622	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119216622G>A	ENST00000555262.1	-	4	447	c.288C>T	c.(286-288)ccC>ccT	p.P96P	C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR|MFRP_ENST00000449574.2_Silent_p.P96P|MFRP_ENST00000360167.4_Silent_p.P96P|MFRP_ENST00000530681.1_Silent_p.P96P	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CCCCAGATGGGGGTGCAGCCT	0.642000													22	48					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94512578	94512578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94512578C>T	ENST00000370225.3	-	19	2901	c.2815G>A	c.(2815-2817)Gag>Aag	p.E939K	ABCA4_ENST00000535735.1_Missense_Mutation_p.E865K	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	939	ABC transporter 1.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CCACAGGGCTCAAAAATCTTT	0.507000													24	249					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67941580	67941580	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:67941580C>T	ENST00000252336.6	+	9	2583	c.2211C>T	c.(2209-2211)ccC>ccT	p.P737P	STARD8_ENST00000374597.3_Silent_p.P737P|STARD8_ENST00000374599.3_Silent_p.P817P	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	737	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						AGGATAGCCCCTCTCCCAGGT	0.577000													17	16					0	0	1	0	0
ACMSD	130013	broad.mit.edu	37	2	135625210	135625210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:135625210G>A	ENST00000356140.5	+	6	684	c.548G>A	c.(547-549)cGa>cAa	p.R183Q	ACMSD_ENST00000392928.1_Missense_Mutation_p.R125Q|AC016725.4_ENST00000428857.1_RNA|AC016725.4_ENST00000537615.1_RNA|ACMSD_ENST00000283054.4_Missense_Mutation_p.R125Q|AC016725.4_ENST00000413962.1_RNA|AC016725.4_ENST00000392929.2_RNA	NM_138326.2	NP_612199.2	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	183					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			endometrium(3)|large_intestine(4)|lung(6)|skin(1)	14				BRCA - Breast invasive adenocarcinoma(221;0.115)		ATGGATGGACGAATGGCCAAA	0.498000													54	94					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48429431	48429431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48429431G>A	ENST00000224605.2	-	2	720	c.455C>T	c.(454-456)cCg>cTg	p.P152L		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	152					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CTTGGCCCGCGGCTTGCATAG	0.652000													3	17					0	0	1	0	0
PRAM1	84106	broad.mit.edu	37	19	8563993	8563993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8563993G>A	ENST00000423345.4	-	2	1219	c.699C>T	c.(697-699)gtC>gtT	p.V233V	PRAM1_ENST00000255612.3_Silent_p.V233V			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	281	Pro-rich.						lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						GGAGGCCACCGACCTGAGGCT	0.632000													13	32					0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886538	57886538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57886538G>A	ENST00000302610.1	-	1	378	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				AGTGGGTTGCGAATGGCAGCA	0.562000													12	56					0	0	1	0	0
CLEC6A	93978	broad.mit.edu	37	12	8610536	8610536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8610536G>A	ENST00000382073.3	+	2	260	c.74G>A	c.(73-75)gGg>gAg	p.G25E		NM_001007033.1	NP_001007034.1	Q6EIG7	CLC6A_HUMAN	C-type lectin domain family 6, member A	25					defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)|large_intestine(2)|lung(7)	10	Lung SC(5;0.184)					TCTGTGGCTGGGATTTCCATT	0.493000													24	51					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729423	18729423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18729423C>T	ENST00000440756.2	-	3	1053	c.951G>A	c.(949-951)caG>caA	p.Q317Q	PSD3_ENST00000327040.8_Silent_p.Q317Q|PSD3_ENST00000523619.1_Silent_p.Q252Q			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	317					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTATAGGATGCTGGGTCTCTC	0.502000													52	136					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188066	152188066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152188066G>A	ENST00000368801.2	-	3	6114	c.6039C>T	c.(6037-6039)tcC>tcT	p.S2013S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2013					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGGGTAGAGGAATGACCTG	0.557000													104	1413					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82124521	82124521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82124521G>A	ENST00000199936.4	+	4	872	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	227					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	GGCCCCAATGGAAAGGCTGGC	0.413000													5	39					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57013070	57013070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:57013070C>T	ENST00000370706.4	+	10	2431	c.2187C>T	c.(2185-2187)atC>atT	p.I729I	RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Silent_p.I729I|RP11-203B9.4_ENST00000589549.1_RNA|ZNF451_ENST00000491832.2_Silent_p.I729I|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	729					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AGAGTTACATCTGTAAAGTCA	0.383000													10	42					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37774261	37774261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37774261G>A	ENST00000264741.5	+	19	2382	c.2126G>A	c.(2125-2127)gGa>gAa	p.G709E		NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	709					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TGCAGCGTGGGATTTCCTTTC	0.562000													3	17					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764593	92764593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92764593G>A	ENST00000318238.4	-	5	1908	c.692C>T	c.(691-693)tCa>tTa	p.S231L	SAMD9L_ENST00000411955.1_Missense_Mutation_p.S231L|SAMD9L_ENST00000437805.1_Missense_Mutation_p.S231L	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	231										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			ATTGGTGCGTGAATTCATACA	0.438000													42	96					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61459284	61459284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61459284G>A	ENST00000343916.3	+	17	859	c.856G>A	c.(856-858)Ggt>Agt	p.G286S		NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	286	Triple-helical region 3 (COL3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					GGGCAGACCTGGTCCCAAGGG	0.642000													33	49					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363912	22363912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22363912C>T	ENST00000397121.2	-	3	924	c.607G>A	c.(607-609)Ggc>Agc	p.G203S		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAGGCTTTGCCACATTCTTCA	0.358000													26	84					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22079094	22079094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22079094G>A	ENST00000454243.2	-	5	1339	c.765C>T	c.(763-765)ccC>ccT	p.P255P	PHYHIP_ENST00000321613.3_Silent_p.P255P	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	255										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		TGTCCAGGAGGGGCAGGCGGT	0.622000													14	40					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8971824	8971824	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8971824C>T	ENST00000397910.4	-	78	42971	c.42767_splice	c.e78-1	p.T14256_splice	MUC16_ENST00000380951.5_Splice_Site_p.T897_splice	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14319	SEA 15.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CGGAGTCCATCCTAGGGACAG	0.507000													5	9					0	0	1	0	0
ORM1	5004	broad.mit.edu	37	9	117087420	117087420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117087420C>T	ENST00000259396.8	+	5	606	c.528C>T	c.(526-528)acC>acT	p.T176T	ORM1_ENST00000477456.1_3'UTR	NM_000607.2	NP_000598.2	P02763	A1AG1_HUMAN	orosomucoid 1	176					acute-phase response|regulation of immune system process|transport	extracellular space	protein binding			endometrium(2)|large_intestine(4)|lung(2)	8		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	TCGTGTACACCGATTGGAAAA	0.577000													21	52					0	0	1	0	0
ACTG2	72	broad.mit.edu	37	2	74140694	74140694	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74140694C>T	ENST00000409624.1	+	7	1177	c.534C>T	c.(532-534)cgC>cgT	p.R178R	ACTG2_ENST00000409731.3_Silent_p.R135R|ACTG2_ENST00000345517.3_Silent_p.R178R			P63267	ACTH_HUMAN	actin, gamma 2, smooth muscle, enteric	178					muscle contraction	cytoskeleton|cytosol	ATP binding			large_intestine(3)|lung(14)|skin(1)	18						CCATCATGCGCCTGGACTTGG	0.552000													32	105					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58111395	58111395	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58111395C>T	ENST00000357272.4	+	23	4151	c.3986C>T	c.(3985-3987)tCt>tTt	p.S1329F	FLNB_ENST00000358537.3_Missense_Mutation_p.S1329F|FLNB_ENST00000295956.4_Missense_Mutation_p.S1329F|FLNB_ENST00000429972.2_Missense_Mutation_p.S1329F|FLNB_ENST00000490882.1_Missense_Mutation_p.S1329F|FLNB_ENST00000348383.5_Missense_Mutation_p.S1329F|FLNB_ENST00000419752.2_Missense_Mutation_p.S1160F|FLNB_ENST00000493452.1_Missense_Mutation_p.S1160F			O75369	FLNB_HUMAN	filamin B, beta	1329	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding	p.S1329Y(2)		NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TGCCAGCCATCTAGGGTGCAA	0.517000													29	90					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55179107	55179107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55179107C>T	ENST00000391736.1	+	13	1378	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S	LILRB4_ENST00000270452.2_Missense_Mutation_p.P355S|LILRB4_ENST00000430952.2_Missense_Mutation_p.P354S|LILRB4_ENST00000391733.3_Missense_Mutation_p.P356S|LILRB4_ENST00000391734.3_Intron	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	355						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CGATGAAGACCCCCAGGCAGT	0.567000													16	80					0	0	1	0	0
KRT81	3887	broad.mit.edu	37	12	52685159	52685159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52685159G>A	ENST00000327741.5	-	1	159	c.91C>T	c.(91-93)Ccc>Tcc	p.P31S	KRT86_ENST00000544024.1_Intron|KRT86_ENST00000423955.2_Intron	NM_002281.3	NP_002272.2	Q14533	KRT81_HUMAN	keratin 81	31	Head.					keratin filament	protein binding|structural molecule activity			breast(2)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|stomach(1)	16				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCACGGTAGGGGGCGGCGGTG	0.716000													5	14					0	0	1	0	0
POMC	5443	broad.mit.edu	37	2	25384191	25384191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:25384191C>T	ENST00000405623.1	-	3	1018	c.563G>A	c.(562-564)gGa>gAa	p.G188E	POMC_ENST00000264708.3_Missense_Mutation_p.G188E|POMC_ENST00000380794.1_Missense_Mutation_p.G188E|POMC_ENST00000395826.2_Missense_Mutation_p.G188E			P01189	COLI_HUMAN	proopiomelanocortin	188					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	GGGGCCATCTCCCTCCCGGAG	0.706000													6	8					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475029	16475029	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16475029G>A	ENST00000358432.5	-	3	821	c.667C>T	c.(667-669)Ctg>Ttg	p.L223L	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	223	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ACAGTGGCCAGGGAAGGTGCA	0.667000													7	55					0	0	1	0	0
IL9R	3581	broad.mit.edu	37	X	155235133	155235133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:155235133C>T	ENST00000424344.3	+	7	1074	c.707C>T	c.(706-708)cCc>cTc	p.P236L	IL9R_ENST00000369423.2_Missense_Mutation_p.P292L|IL9R_ENST00000244174.5_Missense_Mutation_p.P257L|IL9R_ENST00000540897.1_Missense_Mutation_p.P282L			Q01113	IL9R_HUMAN	interleukin 9 receptor	257	Fibronectin type-III.				cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTCCAGGCTCCCCAGAGACAA	0.617000													9	31					0	0	1	0	0
ZNF121	7675	broad.mit.edu	37	19	9677162	9677162	+	Silent	SNP	G	G	A	rs147272207		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9677162G>A	ENST00000586602.1	-	6	1043	c.627C>T	c.(625-627)ttC>ttT	p.F209F	ZNF121_ENST00000320451.6_Silent_p.F209F			P58317	ZN121_HUMAN	zinc finger protein 121	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(4)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	24						AGCGCCCAGCGAAGGCTCTTC	0.418000													29	60					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123152144	123152144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123152144G>A	ENST00000466202.1	-	2	827	c.251C>T	c.(250-252)tCa>tTa	p.S84L	IQUB_ENST00000488987.1_Intron|IQUB_ENST00000434450.1_Missense_Mutation_p.S84L|IQUB_ENST00000324698.6_Missense_Mutation_p.S84L			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	84										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						TTGTCTTGGTGATATAACCTC	0.398000													17	194					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27147884	27147884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27147884C>T	ENST00000288699.6	+	3	549	c.391C>T	c.(391-393)Cac>Tac	p.H131Y	DPYSL5_ENST00000401478.1_Missense_Mutation_p.H131Y	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	131					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTACGCCCTCCACGTGGGGAT	0.612000													12	32					0	0	1	0	0
GHRH	2691	broad.mit.edu	37	20	35885233	35885233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35885233G>A	ENST00000373614.2	-	2	171	c.60C>T	c.(58-60)tcC>tcT	p.S20S	GHRH_ENST00000237527.3_Silent_p.S20S|GHRH_ENST00000373611.2_Silent_p.S20S			P01286	SLIB_HUMAN	growth hormone releasing hormone	20					activation of adenylate cyclase activity by G-protein signaling pathway|adenohypophysis development|growth hormone secretion|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of circadian sleep/wake cycle, REM sleep|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to food	extracellular space|terminal button	growth hormone-releasing hormone activity|growth hormone-releasing hormone receptor binding			lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Myeloproliferative disorder(115;0.00878)				GGGGAGGTGGGGAGCAGTGGG	0.597000													8	13					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13769648	13769648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13769648C>T	ENST00000265104.4	-	57	9786	c.9682G>A	c.(9682-9684)Gaa>Aaa	p.E3228K	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3228	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGCTCCTTTTCTTTCGCTTCC	0.433000									Kartagener syndrome				65	149					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96332162	96332162	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:96332162C>T	ENST00000231368.5	+	7	2168	c.1476C>T	c.(1474-1476)ttC>ttT	p.F492F	LNPEP_ENST00000395770.3_Silent_p.F478F	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	492					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		TTGCCACTTTCATGGAGTATT	0.393000													11	53					0	0	1	0	0
IGLC7	28834	broad.mit.edu	37	22	23265006	23265006	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23265006C>T	ENST00000390331.1	+	0	241																											CAGTGGAAGTCCCACAGAAGC	0.612000													12	66					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6026741	6026741	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:6026741T>C	ENST00000265849.7	-	11	1760	c.1655A>G	c.(1654-1656)cAt>cGt	p.H552R	PMS2_ENST00000441476.2_Missense_Mutation_p.H446R|PMS2_ENST00000406569.3_Missense_Mutation_p.H552R|PMS2_ENST00000469652.1_Intron|PMS2_ENST00000382321.4_Intron	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	552					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CTGGTTTGAATGGCAGTCCAC	0.473000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				88	217					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49087963	49087963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49087963G>A	ENST00000261900.3	-	9	1256	c.1034C>T	c.(1033-1035)cCt>cTt	p.P345L		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	345					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						ACCCTGAGTAGGTTCTAGTTT	0.473000													32	76					0	0	1	0	0
ZNF688	146542	broad.mit.edu	37	16	30581396	30581396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30581396G>A	ENST00000223459.6	-	3	1776	c.672C>T	c.(670-672)ttC>ttT	p.F224F	ZNF688_ENST00000395219.1_Silent_p.F210F	NM_145271.3	NP_660314.1	P0C7X2	ZN688_HUMAN	zinc finger protein 688	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8						CTTCCACTGCGAACTTCCTCT	0.706000													5	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569663	179569663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179569663C>T	ENST00000589042.1	-	104	29859	c.29635G>A	c.(29635-29637)Gac>Aac	p.D9879N	TTN_ENST00000342992.6_Missense_Mutation_p.D8635N|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.D9562N|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9562	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTTTCGTCCCTCTCTGAC	0.323000													44	139					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42607138	42607138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42607138G>A	ENST00000359486.3	-	1	4310	c.4174C>T	c.(4174-4176)Cct>Tct	p.P1392S	TCF20_ENST00000335626.4_Missense_Mutation_p.P1392S	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CCTTCAGGAGGACCACTCTTC	0.507000													19	110					0	0	1	0	0
RETSAT	54884	broad.mit.edu	37	2	85577343	85577343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:85577343G>A	ENST00000295802.4	-	4	731	c.619C>T	c.(619-621)Cat>Tat	p.H207Y	RETSAT_ENST00000457495.2_Missense_Mutation_p.H146Y|RETSAT_ENST00000263854.6_Missense_Mutation_p.H207Y	NM_017750.3	NP_060220.3	Q6NUM9	RETST_HUMAN	retinol saturase (all-trans-retinol 13,14-reductase)	207					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	30					Vitamin A(DB00162)	AGGATGGCATGAGGGGCTCCA	0.562000													14	59					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146829430	146829430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:146829430G>A	ENST00000361727.3	+	8	1693	c.1177G>A	c.(1177-1179)Gac>Aac	p.D393N		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	393					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCTTAACCAGGACCTGTTCTC	0.478000										HNSCC(39;0.1)			30	83					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40964869	40964869	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:40964869G>A	ENST00000313164.9	+	14	2135	c.1776G>A	c.(1774-1776)ggG>ggA	p.G592G		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	592	Sushi 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				TTCCTGTGGGGAAAAATGTAG	0.368000													27	65					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64738836	64738836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64738836G>A	ENST00000413366.3	+	13	1508	c.1482G>A	c.(1480-1482)acG>acA	p.T494T		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	494	Protein kinase.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	ATGGAGTCACGACCAGGACCT	0.483000													36	79					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66192507	66192507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66192507G>A	ENST00000311034.2	+	7	2322	c.2146G>A	c.(2146-2148)Gat>Aat	p.D716N		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	716					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CATCTTCATGGATCTCTCTAC	0.592000													45	71					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47938716	47938716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47938716C>T	ENST00000402813.3	-	10	2144	c.2002G>A	c.(2002-2004)Ggg>Agg	p.G668R	CNGA1_ENST00000358519.4_Missense_Mutation_p.G599R|CNGA1_ENST00000514170.1_Missense_Mutation_p.G599R|CNGA1_ENST00000420489.2_Missense_Mutation_p.G599R|CNGA1_ENST00000544810.1_Missense_Mutation_p.G599R			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	599					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						ATCTGCTTCCCTTTCTCTTCC	0.418000													64	197					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62871152	62871152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62871152G>A	ENST00000536311.1	+	22	3578	c.3214G>A	c.(3214-3216)Gag>Aag	p.E1072K	MYT1_ENST00000328439.1_Missense_Mutation_p.E1045K			Q01538	MYT1_HUMAN	myelin transcription factor 1	1045					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CATCGAGGAGGAGAACAAGCT	0.577000													28	76					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2983282	2983282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2983282G>A	ENST00000342628.2	-	2	476	c.363C>T	c.(361-363)ctC>ctT	p.L121L	FOXM1_ENST00000361953.3_Silent_p.L121L|FOXM1_ENST00000537018.1_5'UTR|FOXM1_ENST00000359843.3_Silent_p.L121L	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	121					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TTTGAGGCCGGAGTCCTGGAG	0.542000													36	99					0	0	1	0	0
MSTN	2660	broad.mit.edu	37	2	190925110	190925110	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:190925110A>C	ENST00000260950.4	-	2	557	c.425T>G	c.(424-426)tTt>tGt	p.F142C	C2orf88_ENST00000478197.1_Intron	NM_005259.2	NP_005250.1	O14793	GDF8_HUMAN	myostatin	142					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)	12			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TTTAGAGCTAAATTTAAAGAA	0.333000													18	59					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134896158	134896158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134896158C>T	ENST00000607359.1	+	6	1244	c.1244C>T	c.(1243-1245)aCc>aTc	p.T415I				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GCCTACGAGACCCACGGCCTT	0.607000													12	26					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219760	67219760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67219760G>A	ENST00000312457.2	-	1	440	c.436C>T	c.(436-438)Cgc>Tgc	p.R146C		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	146						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AGGGGCAGGCGGACTGGGCGG	0.701000													14	32					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104064570	104064570	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104064570C>T	ENST00000388887.2	+	22	2560	c.2356C>T	c.(2356-2358)Cct>Tct	p.P786S		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	786					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TAAATACGGACCTCGGTGTAA	0.557000													4	22					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513335	99513335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:99513335G>A	ENST00000261037.3	+	5	970	c.590G>A	c.(589-591)gGa>gAa	p.G197E	COL8A1_ENST00000273342.4_Missense_Mutation_p.G197E	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	197	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGACCACAAGGACCTCCAGGG	0.587000													18	46					0	0	1	0	0
MICU1	10367	broad.mit.edu	37	10	74167714	74167714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74167714G>A	ENST00000398761.4	-	12	1291	c.1159C>T	c.(1159-1161)Cat>Tat	p.H387Y	MICU1_ENST00000418483.2_Missense_Mutation_p.H187Y|MICU1_ENST00000398763.4_Missense_Mutation_p.H187Y|MICU1_ENST00000401998.3_Missense_Mutation_p.H385Y|MICU1_ENST00000361114.5_Missense_Mutation_p.H385Y			Q9BPX6	MICU1_HUMAN	mitochondrial calcium uptake 1	385					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding										CCAGCCATATGGTAAAAACTC	0.403000													12	41					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56490832	56490832	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56490832G>A	ENST00000291971.3	+	9	3020	c.2949G>A	c.(2947-2949)ctG>ctA	p.L983L	NLRP8_ENST00000590542.1_Silent_p.L964L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	983						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		ACCAACATCTGAGACATCTGG	0.493000													50	112					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38936375	38936375	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38936375C>T	ENST00000302328.3	-	15	2682	c.2484G>A	c.(2482-2484)agG>agA	p.R828R	SCN11A_ENST00000456224.3_Silent_p.R828R|SCN11A_ENST00000444237.2_Silent_p.R828R|SCN11A_ENST00000450244.1_Silent_p.R828R	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	828					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTTAGTTTTCCTGGCCTCTC	0.468000													20	58					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20856143	20856143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20856143G>A	ENST00000262715.5	-	18	2645	c.2605C>T	c.(2605-2607)Cca>Tca	p.P869S	TEP1_ENST00000556935.1_Missense_Mutation_p.P761S	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	869					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GTCTTTCCTGGGGGTGGTGGA	0.512000													21	61					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771847	143771847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143771847G>A	ENST00000408898.2	+	1	573	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					CTTTTTCTGTGAAATTATGGC	0.463000													65	161					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71891404	71891404	+	Silent	SNP	C	C	T	rs151276652	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71891404C>T	ENST00000258104.3	+	45	5170	c.4893C>T	c.(4891-4893)ttC>ttT	p.F1631F	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Silent_p.F1632F|DYSF_ENST00000409744.1_Silent_p.F1639F|DYSF_ENST00000410020.3_Silent_p.F1670F|DYSF_ENST00000413539.2_Silent_p.F1662F|DYSF_ENST00000429174.2_Silent_p.F1652F|DYSF_ENST00000409366.1_Silent_p.F1653F|DYSF_ENST00000409582.3_Silent_p.F1669F|DYSF_ENST00000409762.1_Silent_p.F1648F|DYSF_ENST00000409651.1_Silent_p.F1663F|DYSF_ENST00000410041.1_Silent_p.F1649F	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1631	C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GCAGGATGTTCGAGCTGACCT	0.572000													33	65					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107791	55107791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55107791C>T	ENST00000251372.3	+	7	1278	c.1096C>T	c.(1096-1098)Ccc>Tcc	p.P366S	LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	366	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		AGCTGATGCCCCCCTCCGTCT	0.592000													51	110					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121290798	121290798	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121290798C>T	ENST00000297848.3	+	28	3732	c.3462C>T	c.(3460-3462)tcC>tcT	p.S1154S	COL14A1_ENST00000247781.3_Silent_p.S1059S|COL14A1_ENST00000309791.4_Silent_p.S1154S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1154	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACAAAATCTCCAGGGAGATGC	0.348000													6	56					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57828693	57828693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57828693C>T	ENST00000309668.2	+	1	151	c.24C>T	c.(22-24)gcC>gcT	p.A8A	INHBC_ENST00000550133.1_Silent_p.A8A	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	8					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						TGCTTCTGGCCTTTCTCCTCC	0.602000													7	39					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39804951	39804951	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39804951C>T	ENST00000248668.4	-	1	1025	c.1026G>A	c.(1024-1026)ggG>ggA	p.G342G		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	342	Ig-like.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGCTGGAGTTCCCCAGCAGCC	0.687000													7	8					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51743021	51743021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51743021C>T	ENST00000395052.3	+	2	256	c.22C>T	c.(22-24)Ctg>Ttg	p.L8L	GRM2_ENST00000442933.2_Silent_p.L8L|GRM2_ENST00000475478.1_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	8					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCTTGCGCTCCTGGCACTGCT	0.632000													7	19					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155451141	155451141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155451141G>A	ENST00000461783.3	+	6	2057	c.784G>A	c.(784-786)Gag>Aag	p.E262K	TIAM2_ENST00000456144.1_Missense_Mutation_p.E262K|TIAM2_ENST00000318981.5_Missense_Mutation_p.E262K|TIAM2_ENST00000360366.4_Missense_Mutation_p.E262K|TIAM2_ENST00000529824.2_Missense_Mutation_p.E262K|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	262					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGAGCTGAGCGAGGCTGAGGG	0.617000													34	41					0	0	1	0	0
TNFSF14	8740	broad.mit.edu	37	19	6665012	6665012	+	Silent	SNP	G	G	A	rs143839697		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6665012G>A	ENST00000326176.9	-	5	921	c.540C>T	c.(538-540)gtC>gtT	p.V180V	TNFSF14_ENST00000599359.1_Silent_p.V216V|TNFSF14_ENST00000245912.3_Silent_p.V180V	NM_003807.3|NM_172014.2	NP_003798.2|NP_742011.2	O43557	TNF14_HUMAN	tumor necrosis factor (ligand) superfamily, member 14	216					cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding	p.V216V(1)		breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18						GCACACGGACGACCACCTTCT	0.622000													39	83					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90129102	90129102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90129102C>T	ENST00000268138.7	+	4	1445	c.1340C>T	c.(1339-1341)tCc>tTc	p.S447F	TICRR_ENST00000560985.1_Missense_Mutation_p.S446F|RP11-429B14.1_ENST00000559041.1_RNA					TOPBP1-interacting checkpoint and replication regulator																		GACACAGCTTCCCTTTTCTCA	0.483000													84	72					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86416290	86416290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86416290G>A	ENST00000361669.2	+	3	2281	c.1182G>A	c.(1180-1182)gtG>gtA	p.V394V	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Silent_p.V266V|GRM3_ENST00000394720.2_Silent_p.V392V|GRM3_ENST00000439827.1_Silent_p.V394V	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	394					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGTTTGTGGTGAACGCGGTGT	0.547000													32	91					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117655926	117655926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117655926C>T	ENST00000317775.6	-	28	4899	c.4214G>A	c.(4213-4215)cGa>cAa	p.R1405Q	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.R1439Q	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1405					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTCGTACGTTCGCAGGGTGAC	0.478000													78	292					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47280923	47280923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47280923G>A	ENST00000271153.4	+	8	1093	c.1057G>A	c.(1057-1059)Gac>Aac	p.D353N	CYP4B1_ENST00000371919.4_Missense_Mutation_p.D339N|CYP4B1_ENST00000452782.2_Missense_Mutation_p.D191N|CYP4B1_ENST00000371923.4_Missense_Mutation_p.D354N			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	353					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					AGGGGACCAGGACTTCTTCCA	0.582000													13	27					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1262685	1262685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1262685G>A	ENST00000447027.1	+	31	4642	c.4584G>A	c.(4582-4584)ggG>ggA	p.G1528G	MUC5B_ENST00000529681.1_Silent_p.G1525G			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1525	7 X Cys-rich subdomain repeats.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AACTTGGAGGGGACGTTGAGT	0.607000													11	16					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74013982	74013982	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74013982G>A	ENST00000301607.3	-	14	1801	c.1548C>T	c.(1546-1548)ggC>ggT	p.G516G	EVPL_ENST00000586740.1_Silent_p.G538G	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	516	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CCAGGTCTGAGCCAGATGGAG	0.657000													18	55					0	0	1	0	0
STARD7	56910	broad.mit.edu	37	2	96859059	96859059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96859059G>A	ENST00000337288.5	-	4	964	c.581C>T	c.(580-582)gCc>gTc	p.A194V	STARD7_ENST00000462501.1_5'UTR	NM_020151.3	NP_064536.2	Q9NQZ5	STAR7_HUMAN	StAR-related lipid transfer (START) domain containing 7	194	START.					mitochondrion				endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|stomach(2)	14						GATTACCAGGGCATCCCATTT	0.423000													48	98					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45923763	45923763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45923763C>T	ENST00000348697.2	+	4	505	c.358C>T	c.(358-360)Cag>Tag	p.Q120*	FBLN1_ENST00000340923.5_Nonsense_Mutation_p.Q120*|FBLN1_ENST00000402984.3_Nonsense_Mutation_p.Q158*|FBLN1_ENST00000442170.2_Nonsense_Mutation_p.Q120*|FBLN1_ENST00000327858.6_Nonsense_Mutation_p.Q120*|FBLN1_ENST00000262722.7_Nonsense_Mutation_p.Q120*			P23142	FBLN1_HUMAN	fibulin 1	120	Anaphylatoxin-like 3.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GAGGGCGGCCCAGGCCCAGGG	0.627000													20	116					0	0	1	0	0
RGP1	9827	broad.mit.edu	37	9	35750689	35750689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35750689G>A	ENST00000378078.4	+	4	429	c.288G>A	c.(286-288)ccG>ccA	p.P96P	RGP1_ENST00000456972.2_Silent_p.P136P	NM_001080496.2	NP_001073965.2	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog (S. cerevisiae)	96										cervix(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTACTCCACCGAAAATTCTAT	0.458000													12	48					0	0	1	0	0
TRIM32	22954	broad.mit.edu	37	9	119461243	119461243	+	Missense_Mutation	SNP	C	C	A	rs3747835	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119461243C>A	ENST00000450136.1	+	2	1383	c.1222C>A	c.(1222-1224)Cgc>Agc	p.R408S	ASTN2_ENST00000313400.4_Intron|ASTN2_ENST00000373996.3_Intron|ASTN2_ENST00000361209.2_Intron|TRIM32_ENST00000373983.2_Missense_Mutation_p.R408S|ASTN2_ENST00000361477.3_Intron	NM_001099679.1|NM_012210.3	NP_001093149.1|NP_036342.2	Q13049	TRI32_HUMAN	tripartite motif containing 32	408			R -> C (in dbSNP:rs3747835).		fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	26						GAAGGAAATCCGCCGCAGCCC	0.512000													51	119					4.78724e-31	4.82031e-31	1	1	0
IFT80	57560	broad.mit.edu	37	3	160025566	160025566	+	Missense_Mutation	SNP	G	G	A	rs140972476		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:160025566G>A	ENST00000326448.7	-	10	1393	c.961C>T	c.(961-963)Cgt>Tgt	p.R321C	IFT80_ENST00000483465.1_Missense_Mutation_p.R184C|IFT80_ENST00000496589.1_Missense_Mutation_p.R184C|RP11-432B6.3_ENST00000483754.1_Missense_Mutation_p.R492C	NM_020800.2	NP_065851.1	Q9P2H3	IFT80_HUMAN	intraflagellar transport 80 homolog (Chlamydomonas)	321						cilium axoneme|microtubule basal body				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(12)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AGAACATTACGAACCTAAACA	0.289000													8	30					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15686188	15686188	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15686188C>T	ENST00000378076.3	-	13	1593	c.1240G>A	c.(1240-1242)Gat>Aat	p.D414N		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	414					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CCTCTTTGATCCTTGCCTGCA	0.398000													21	32					0	0	1	0	0
IFNA14	3448	broad.mit.edu	37	9	21239489	21239489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21239489C>T	ENST00000380222.2	-	1	489	c.446G>A	c.(445-447)aGa>aAa	p.R149K		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	149					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AAGAGTGATTCTTTGGAAGTA	0.458000													136	307					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100197701	100197701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100197701C>T	ENST00000241071.6	+	9	1576	c.1254C>T	c.(1252-1254)caC>caT	p.H418H	FBXO24_ENST00000468962.1_Silent_p.H406H|FBXO24_ENST00000360609.2_3'UTR|PCOLCE-AS1_ENST00000544873.1_RNA|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000427939.2_Silent_p.H456H	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	418						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GCCTCAACCACTCCCTGGTGC	0.692000													3	13					0	0	1	0	0
AKR1C1	1645	broad.mit.edu	37	10	5014844	5014844	+	Missense_Mutation	SNP	G	G	A	rs140396306		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5014844G>A	ENST00000380872.4	+	7	941	c.749G>A	c.(748-750)cGa>cAa	p.R250Q	AKR1C1_ENST00000434459.2_Missense_Mutation_p.R250Q|AKR1C1_ENST00000477661.1_3'UTR	NM_001353.5	NP_001344.2			aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						AAGCACAAGCGAACCCCAGCC	0.597000													31	127					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41519017	41519017	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41519017C>T	ENST00000396942.1	-	42	5768	c.5685G>A	c.(5683-5685)gtG>gtA	p.V1895V	ANK1_ENST00000522543.1_Intron|ANK1_ENST00000352337.4_Silent_p.V1848V|ANK1_ENST00000314214.8_Silent_p.V145V|ANK1_ENST00000396945.1_Intron|RP11-930P14.1_ENST00000520418.1_RNA|ANK1_ENST00000289734.7_Silent_p.V1870V|ANK1_ENST00000379758.2_Intron|ANK1_ENST00000265709.8_Intron|ANK1_ENST00000522231.1_Intron|RP11-930P14.1_ENST00000522388.1_RNA|RP11-930P14.1_ENST00000585088.1_RNA|ANK1_ENST00000347528.4_Intron|ANK1_ENST00000457297.1_Intron			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	0					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGGCCCGCTTCACTATCTGCG	0.612000													20	60					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71478775	71478775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71478775G>A	ENST00000265382.3	+	5	397	c.92G>A	c.(91-93)gGt>gAt	p.G31D	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.G31D	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	31	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		GCTATTAAAGGTGCTATTCAG	0.423000													36	149					0	0	1	0	0
KCNV2	169522	broad.mit.edu	37	9	2717932	2717932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:2717932G>A	ENST00000382082.3	+	1	431	c.193G>A	c.(193-195)Gac>Aac	p.D65N		NM_133497.3	NP_598004.1	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	65						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	35				GBM - Glioblastoma multiforme(50;0.0257)		CGAGGAGGAGGACCAGTGGAA	0.662000													5	52					0	0	1	0	0
MTA1	9112	broad.mit.edu	37	14	105936526	105936526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105936526G>A	ENST00000331320.7	+	21	2336	c.2122G>A	c.(2122-2124)Gac>Aac	p.D708N	RP11-521B24.5_ENST00000552675.1_RNA|MTA1_ENST00000435036.2_Missense_Mutation_p.D248N|MTA1_ENST00000406191.1_Missense_Mutation_p.D696N|MTA1_ENST00000405646.1_Missense_Mutation_p.D691N	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1	708					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GCCCGTCAACGACGAGCCCAT	0.776000													12	17					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130479928	130479928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130479928G>A	ENST00000373289.3	+	4	383	c.303G>A	c.(301-303)cgG>cgA	p.R101R	TTC16_ENST00000393748.4_5'UTR|PTRH1_ENST00000419060.1_Intron|PTRH1_ENST00000429848.1_Intron	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	101							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						ATGCCTTACGGGCTGAGGCCT	0.627000													24	41					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130712923	130712923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130712923G>A	ENST00000510168.1	+	22	2588	c.2038G>A	c.(2038-2040)Gat>Aat	p.D680N	ATP2C1_ENST00000504948.1_Missense_Mutation_p.D664N|ATP2C1_ENST00000504381.1_Missense_Mutation_p.D625N|ATP2C1_ENST00000533801.2_Missense_Mutation_p.D675N|ATP2C1_ENST00000505330.1_Missense_Mutation_p.D664N|ATP2C1_ENST00000428331.2_Missense_Mutation_p.D680N|ATP2C1_ENST00000507488.2_Missense_Mutation_p.D664N|ATP2C1_ENST00000508532.1_Missense_Mutation_p.D680N|ATP2C1_ENST00000393221.4_Missense_Mutation_p.D714N|ATP2C1_ENST00000359644.3_Missense_Mutation_p.D680N|ATP2C1_ENST00000328560.8_Missense_Mutation_p.D680N|ATP2C1_ENST00000422190.2_Missense_Mutation_p.D680N|ATP2C1_ENST00000513801.1_Missense_Mutation_p.D664N			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	680					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	CCTAGTGGATGATGATTTTCA	0.458000									Hailey-Hailey disease				43	70					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160679494	160679494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160679494C>T	ENST00000366952.1	-	3	1714	c.233G>A	c.(232-234)aGc>aAc	p.S78N	SLC22A2_ENST00000366953.3_Missense_Mutation_p.S99N|SLC22A2_ENST00000491092.1_5'UTR			O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	99					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GTCGAAGGTGCTCTGGTTCCA	0.677000													32	39					0	0	1	0	0
GNB3	2784	broad.mit.edu	37	12	6952194	6952194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6952194G>A	ENST00000229264.3	+	5	562	c.157G>A	c.(157-159)Gga>Aga	p.G53R	GNB3_ENST00000435982.2_Missense_Mutation_p.G53R	NM_002075.2	NP_002066.1	P16520	GBB3_HUMAN	guanine nucleotide binding protein (G protein), beta polypeptide 3	53					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|stomach(1)	20						GACGTTAAGGGGACACCTGGC	0.602000													12	42					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56370494	56370494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56370494C>T	ENST00000301295.6	+	3	2157	c.1735C>T	c.(1735-1737)Cat>Tat	p.H579Y	NLRP4_ENST00000346986.5_Missense_Mutation_p.H579Y|NLRP4_ENST00000587891.1_Missense_Mutation_p.H504Y	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	579							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AGCTAACTTTCATATTATTGA	0.428000													27	61					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201438535	201438535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:201438535C>T	ENST00000357799.4	+	7	3564	c.3466C>T	c.(3466-3468)Cgt>Tgt	p.R1156C		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	1156					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						TGACAGTGTTCGTGAAGGTTT	0.363000													31	91					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9623815	9623815	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:9623815T>G	ENST00000310430.6	+	25	3646	c.3620T>G	c.(3619-3621)aTg>aGg	p.M1207R	TNKS_ENST00000518281.1_Missense_Mutation_p.M970R	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	1207	PARP catalytic.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		ATAGGAGGAATGTTTGGGGCC	0.408000													52	117					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139197070	139197070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139197070G>A	ENST00000274710.3	+	5	1226	c.1021G>A	c.(1021-1023)Gag>Aag	p.E341K		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	341	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCAGCAACGAGTTTAGCAG	0.587000													26	56					0	0	1	0	0
SPA17	53340	broad.mit.edu	37	11	124551353	124551353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124551353G>A	ENST00000532692.1	+	2	1644	c.223G>A	c.(223-225)Gag>Aag	p.E75K	SIAE_ENST00000525730.1_Intron|SPA17_ENST00000524614.1_3'UTR|SPA17_ENST00000227135.2_Missense_Mutation_p.E75K			Q15506	SP17_HUMAN	sperm autoantigenic protein 17	75					binding of sperm to zona pellucida|ciliary or flagellar motility|signal transduction|spermatogenesis	cytoplasm|flagellum|membrane|motile cilium|primary cilium	cAMP-dependent protein kinase regulator activity	p.E75Q(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	5	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0223)		TCATGCATTCGAGGTATGGTC	0.378000													30	50					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39158831	39158831	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39158831C>T	ENST00000359534.3	-	5	1673	c.1335G>A	c.(1333-1335)ggG>ggA	p.G445G		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	445					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						GGCTCTCCTCCCCTGCCAAGT	0.627000													10	24					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237983	140237983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140237983G>A	ENST00000307360.5	+	1	2350	c.2350G>A	c.(2350-2352)Ggg>Agg	p.G784R	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATGTGGACGGGGAAGATCA	0.522000													2	1					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41038970	41038970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41038970C>T	ENST00000399564.4	-	21	2532	c.2082G>A	c.(2080-2082)aaG>aaA	p.K694K	MROH2B_ENST00000506092.2_Silent_p.K249K	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TGGTCAGGCTCTTTTTCCCAG	0.433000													24	66					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28608057	28608057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28608057C>T	ENST00000380982.4	-	15	1990	c.1909G>A	c.(1909-1911)Gtc>Atc	p.V637I	FLT3_ENST00000537084.1_Missense_Mutation_p.V637I|FLT3_ENST00000241453.7_Missense_Mutation_p.V637I			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	637	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGATTGAGACTCCTGTTTTG	0.453000			"""Mis, O"""		"""AML, ALL"""								22	260					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125405466	125405466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125405466G>A	ENST00000431078.1	+	13	2369	c.2005G>A	c.(2005-2007)Gac>Aac	p.D669N		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	669	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGCCGTGATCGACGGCTCTGA	0.632000													6	19					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140174721	140174721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140174721G>A	ENST00000526136.1	+	1	172	c.172G>A	c.(172-174)Gag>Aag	p.E58K	PCDHA2_ENST00000378132.1_Missense_Mutation_p.E58K|PCDHA2_ENST00000520672.2_Missense_Mutation_p.E58K|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGCTGGAGGAGCTGGTGCC	0.632000													76	135					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40652086	40652086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:40652086G>A	ENST00000342449.3	-	9	998	c.920C>T	c.(919-921)tCc>tTc	p.S307F	BRWD1_ENST00000380800.3_Missense_Mutation_p.S307F|BRWD1_ENST00000333229.2_Missense_Mutation_p.S307F	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AAATTTTAAGGATTCTAAATC	0.328000													16	54					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29651802	29651802	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:29651802C>T	ENST00000373779.3	+	29	4341	c.4212C>T	c.(4210-4212)acC>acT	p.T1404T	PTPRU_ENST00000323874.8_Silent_p.T1410T|PTPRU_ENST00000356870.3_Silent_p.T1410T|PTPRU_ENST00000345512.3_Silent_p.T1414T|PTPRU_ENST00000428026.2_Silent_p.T1401T|PTPRU_ENST00000460170.2_Silent_p.T1408T	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1414	Tyrosine-protein phosphatase 2.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CTGCCAAAACCCTCCGGAACT	0.612000													49	125					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842169	5842169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5842169C>T	ENST00000317037.2	+	1	626	c.604C>T	c.(604-606)Ctg>Ttg	p.L202L	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	202					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TATTTATGGTCTGATGGTTGC	0.468000													78	227					0	0	1	0	0
TRAV8-4	28682	broad.mit.edu	37	14	22363169	22363169	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22363169C>T	ENST00000390438.2	+	0	428																											AACCCTCAGCCCATATGAGCG	0.502000													24	73					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880283	74880283	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74880283C>T	ENST00000289575.5	+	5	909	c.514C>T	c.(514-516)Ccc>Tcc	p.P172S	SLCO2B1_ENST00000428359.2_Missense_Mutation_p.P150S|SLCO2B1_ENST00000454962.2_Intron|SLCO2B1_ENST00000341411.4_Intron|SLCO2B1_ENST00000526660.1_Intron|SLCO2B1_ENST00000531756.1_Intron|SLCO2B1_ENST00000532236.1_Missense_Mutation_p.P56S|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.P28S	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	172					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity	p.P172F(1)		breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	AGCCTCGGCCCCCTCCAATGG	0.562000													24	46					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	73000453	73000453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73000453G>A	ENST00000521978.1	+	25	3626	c.3626G>A	c.(3625-3627)gGa>gAa	p.G1209E	RIMS1_ENST00000348717.5_Intron|RIMS1_ENST00000517827.1_Intron|RIMS1_ENST00000538414.1_Intron|RIMS1_ENST00000517960.1_Intron|RIMS1_ENST00000491071.2_Intron|RIMS1_ENST00000522291.1_Intron|RIMS1_ENST00000401910.3_Intron|RIMS1_ENST00000425662.2_Intron|RIMS1_ENST00000523963.1_Intron|RIMS1_ENST00000264839.7_Intron|RIMS1_ENST00000520567.1_Intron|RIMS1_ENST00000518273.1_Intron	NM_014989.5	NP_055804.2	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1209					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GTCATTAGGGGAAAACATCCT	0.517000													4	23					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71044053	71044053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71044053C>T	ENST00000272367.2	-	4	536	c.460G>A	c.(460-462)Gga>Aga	p.G154R	CLEC4F_ENST00000426626.1_Missense_Mutation_p.G154R	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	154					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TTTAGAACTCCTTTTACCATC	0.478000													19	91					0	0	1	0	0
BOLL	66037	broad.mit.edu	37	2	198593232	198593232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:198593232C>T	ENST00000430004.1	-	12	1357	c.961G>A	c.(961-963)Gat>Aat	p.D321N	BOLL_ENST00000392296.4_3'UTR|BOLL_ENST00000321801.7_3'UTR|BOLL_ENST00000282278.8_3'UTR|AC011997.1_ENST00000409845.1_Intron			Q8N9W6	BOLL_HUMAN	boule-like RNA-binding protein	46					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(3)|prostate(1)	13						ACGCAAGGATCATTGGACAAG	0.423000													19	47					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564037	176564037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176564037C>T	ENST00000367662.3	+	3	2461	c.1297C>T	c.(1297-1299)Ctg>Ttg	p.L433L	PAPPA2_ENST00000367661.3_Silent_p.L433L	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	433					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GTCGACCGCCCTGCCACAAAG	0.562000													30	84					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156247733	156247733	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156247733T>A	ENST00000361813.5	-	3	424	c.280A>T	c.(280-282)Atc>Ttc	p.I94F	SMG5_ENST00000368267.4_Missense_Mutation_p.I94F	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	94					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					TTAGTCTTGATAAGCTGGATA	0.483000													77	201					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111141854	111141854	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111141854C>T	ENST00000360467.5	+	35	3576	c.3271_splice	c.e35+1	p.F1090_splice		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1090	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding	p.F1090F(1)		NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CTGGTGATTTCGGTGAGTGTT	0.507000													23	72					0	0	1	0	0
PTGS2	5743	broad.mit.edu	37	1	186646786	186646786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186646786G>A	ENST00000367468.5	-	5	770	c.634C>T	c.(634-636)Cat>Tat	p.H212Y	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	212					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	CTTACCCCATGGCCCAGCCCG	0.408000													47	105					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88420241	88420241	+	Silent	SNP	C	C	T	rs67229046		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88420241C>T	ENST00000394480.1	-	19	2724	c.2403G>A	c.(2401-2403)ttG>ttA	p.L801L	NTRK3_ENST00000357724.2_Silent_p.L807L|NTRK3_ENST00000355254.2_Silent_p.L801L|NTRK3_ENST00000360948.2_Silent_p.L815L|NTRK3_ENST00000557856.1_Silent_p.L793L	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	815	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCTTGATGTTCAACCGCTGCT	0.542000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			19	85					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	333603	333603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:333603G>A	ENST00000343164.4	-	10	1189	c.1137C>T	c.(1135-1137)ttC>ttT	p.F379F	SLC6A13_ENST00000445055.2_Silent_p.F287F	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	379					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CCATGAAGAAGAAACAGCAGG	0.597000													15	98					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258156	56258156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56258156C>T	ENST00000327216.2	-	1	715	c.691G>A	c.(691-693)Gag>Aag	p.E231K		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					TGCCTGCCCTCTGTAGAGCGA	0.408000													11	89					0	0	1	0	0
DPCD	25911	broad.mit.edu	37	10	103348040	103348040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103348040C>T	ENST00000416979.2	+	4	885	c.457C>T	c.(457-459)Cct>Tct	p.P153S	DPCD_ENST00000470165.1_Intron			Q9BVM2	DPCD_HUMAN	deleted in primary ciliary dyskinesia homolog (mouse)	0							protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(1)	5						CGGAAGTGACCCTCTGGAACG	0.612000													3	9					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14781671	14781671	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14781671C>T	ENST00000261170.3	-	20	2294	c.2157_splice	c.e20-1	p.V720_splice		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	720	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AGTAGGTACACCTGGAAGAAA	0.363000													14	72					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209807849	209807849	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209807849C>T	ENST00000391911.1	-	5	896	c.507G>A	c.(505-507)caG>caA	p.Q169Q	LAMB3_ENST00000356082.4_Silent_p.Q169Q|LAMB3_ENST00000367030.3_Silent_p.Q169Q	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	169	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		ACCGAACATCCTGCCAGCTCT	0.607000													23	97					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204804	56204804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56204804G>A	ENST00000361673.3	-	5	2828	c.2615C>T	c.(2614-2616)tCa>tTa	p.S872L	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	872							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CGTAGACACTGAAGTCTCAGA	0.423000													7	50					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113649088	113649088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113649088C>T	ENST00000297405.5	-	22	3917	c.3673G>A	c.(3673-3675)Ggt>Agt	p.G1225S	CSMD3_ENST00000352409.3_Missense_Mutation_p.G1225S|CSMD3_ENST00000343508.3_Missense_Mutation_p.G1185S|CSMD3_ENST00000455883.2_Missense_Mutation_p.G1121S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1225	Sushi 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CGTCGGCCACCACCAAGACAG	0.507000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	65					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33585684	33585684	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33585684C>T	ENST00000404816.2	+	27	4374	c.4021C>T	c.(4021-4023)Caa>Taa	p.Q1341*	LTBP1_ENST00000402934.1_Nonsense_Mutation_p.Q960*|LTBP1_ENST00000354476.3_Nonsense_Mutation_p.Q1342*|LTBP1_ENST00000404525.1_Nonsense_Mutation_p.Q962*|LTBP1_ENST00000407925.1_Nonsense_Mutation_p.Q1015*|LTBP1_ENST00000272273.5_Nonsense_Mutation_p.Q239*|LTBP1_ENST00000390003.4_Nonsense_Mutation_p.Q1016*|LTBP1_ENST00000418533.2_Nonsense_Mutation_p.Q973*			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1341					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGATGTAGATCAACCCAAAGA	0.403000													26	78					0	0	1	0	0
TBCCD1	55171	broad.mit.edu	37	3	186272334	186272334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186272334G>A	ENST00000424280.1	-	6	1732	c.1253C>T	c.(1252-1254)cCt>cTt	p.P418L	TBCCD1_ENST00000338733.5_Missense_Mutation_p.P418L|TBCCD1_ENST00000446782.1_Missense_Mutation_p.P322L	NM_001134415.1	NP_001127887.1	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	418	C-CAP/cofactor C-like.				cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		TGTATGAAAAGGGGCAAAAGT	0.468000													13	41					0	0	1	0	0
BATF3	55509	broad.mit.edu	37	1	212860311	212860311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:212860311C>T	ENST00000243440.1	-	3	428	c.206G>A	c.(205-207)aGc>aAc	p.S69N	BATF3_ENST00000478275.1_5'UTR	NM_018664.2	NP_061134.1	Q9NR55	BATF3_HUMAN	basic leucine zipper transcription factor, ATF-like 3	69	Leucine-zipper.				transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0046)|all cancers(67;0.00785)|GBM - Glioblastoma multiforme(131;0.0731)|Epithelial(68;0.0781)		TTGCTCCAGGCTCTCATATTC	0.557000													69	136					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118764316	118764316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:118764316G>A	ENST00000376300.2	-	3	370	c.233C>T	c.(232-234)tCt>tTt	p.S78F	CCDC93_ENST00000319432.5_Missense_Mutation_p.S78F|AC009303.1_ENST00000588042.1_RNA|AC009303.1_ENST00000590516.1_RNA	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	78										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						ACCTATCGTAGAGTTTTCTTG	0.378000													13	34					0	0	1	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70968663	70968663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70968663C>T	ENST00000359655.4	+	15	2293	c.2233C>T	c.(2233-2235)Cca>Tca	p.P745S		NM_003171.3	NP_003162.2	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 (S. cerevisiae)	745	Interaction with HBXIP, important for protein stability.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding	p.P745A(1)		NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ACTCCTCACTCCAGACATGCT	0.502000													17	50					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24185170	24185170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:24185170G>A	ENST00000396671.2	-	8	908	c.560C>T	c.(559-561)gCc>gTc	p.A187V	THRB_ENST00000416420.1_Missense_Mutation_p.A187V|THRB_ENST00000280696.5_Missense_Mutation_p.A202V|THRB_ENST00000356447.4_Missense_Mutation_p.A187V	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	187					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	CTTCCTCTTGGCCAGCCTCTT	0.572000													6	83					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108117798	108117798	+	Missense_Mutation	SNP	C	C	T	rs138398778		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108117798C>T	ENST00000278616.4	+	8	1394	c.1009C>T	c.(1009-1011)Cgt>Tgt	p.R337C	ATM_ENST00000452508.2_Missense_Mutation_p.R337C	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	337			R -> C (in a colorectal adenocarcinoma sample; somatic mutation).|R -> H (in a colorectal adenocarcinoma sample; somatic mutation).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R337C(3)|p.R337S(2)|p.F336_A340del(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTCAGGATTTCGTAATATTGC	0.323000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			16	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593759	179593759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179593759C>T	ENST00000589042.1	-	65	19230	c.19006G>A	c.(19006-19008)Gat>Aat	p.D6336N	TTN_ENST00000342992.6_Missense_Mutation_p.D5092N|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.D6019N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6019	Ig-like 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGACATTATCATCTTCATCA	0.408000													6	21					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113403696	113403696	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113403696C>T	ENST00000228928.7	+	12	2730	c.2551C>T	c.(2551-2553)Caa>Taa	p.Q851*	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	851	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						GGAGGCATGTCAACAGGAGCG	0.582000													6	20					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151509257	151509257	+	Silent	SNP	G	G	A	rs146901365		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:151509257G>A	ENST00000535741.1	-	40	6746	c.6273C>T	c.(6271-6273)tcC>tcT	p.S2091S	LRBA_ENST00000510413.1_Silent_p.S2091S|LRBA_ENST00000357115.3_Silent_p.S2102S|LRBA_ENST00000507224.1_Silent_p.S2091S			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2102						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AATAGAGTTCGGAGGAGGTGA	0.468000													20	199					0	0	1	0	0
MYLPF	29895	broad.mit.edu	37	16	30387211	30387211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30387211C>T	ENST00000322861.7	+	2	155	c.74C>T	c.(73-75)aCt>aTt	p.T25I		NM_013292.3	NP_037424.2	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast skeletal muscle	25	EF-hand 1.				skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle			large_intestine(2)|lung(4)	6			Colorectal(24;0.193)			TTCGACCAGACTCAGATCCAG	0.597000													5	27					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62203493	62203493	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62203493G>A	ENST00000467148.1	-	1	315	c.246C>T	c.(244-246)ccC>ccT	p.P82P	HELZ2_ENST00000479540.1_5'UTR	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		AGAGTCCCGGGGGTGGGGAAC	0.632000													5	15					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102589725	102589725	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:102589725G>A	ENST00000251808.3	+	7	1319	c.981G>A	c.(979-981)gcG>gcA	p.A327A	GRHL2_ENST00000395927.1_Silent_p.A311A	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	327						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			AGCATACGGCGAAGCAGAGGG	0.498000													5	40					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125516860	125516860	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:125516860C>T	ENST00000241305.3	-	12	1940	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	596					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TAGCTGAAATCGTTCAGACCT	0.493000													41	99					0	0	1	0	0
PRPF31	26121	broad.mit.edu	37	19	54627968	54627968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54627968C>T	ENST00000321030.4	+	8	1137	c.788C>T	c.(787-789)tCg>tTg	p.S263L	PRPF31_ENST00000391755.1_Missense_Mutation_p.S263L|PRPF31_ENST00000419967.1_Missense_Mutation_p.S263L|PRPF31_ENST00000498612.1_3'UTR|AC012314.8_ENST00000452097.1_RNA	NM_015629.3	NP_056444.3	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31	263	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)|urinary_tract(3)	12	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCGGGCTTCTCGTCTACCTCA	0.672000													40	56					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20180764	20180764	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20180764G>A	ENST00000400331.5	-	7	2672	c.2364C>T	c.(2362-2364)gcC>gcT	p.A788A	MACC1_ENST00000589011.1_Silent_p.A788A|MACC1_ENST00000332878.4_Silent_p.A788A	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	788					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						GAAAATCATAGGCAGGTTTCC	0.358000													27	79					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13793832	13793832	+	Silent	SNP	C	C	T	rs112594597		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13793832C>T	ENST00000265104.4	-	49	8120	c.8016G>A	c.(8014-8016)acG>acA	p.T2672T		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2672	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTATCTCATTCGTAACCTACA	0.423000									Kartagener syndrome				20	76					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50683114	50683114	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:50683114G>A	ENST00000008391.3	+	2	553	c.325G>A	c.(325-327)Gag>Aag	p.E109K		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	109							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					CCACCACGGGGAGCCCACCGA	0.627000													17	111					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057770	63057770	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63057770C>T	ENST00000332793.6	+	1	135	c.133C>T	c.(133-135)Cct>Tct	p.P45S	SLC22A10_ENST00000544661.1_5'UTR|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	45						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGCAGCCATTCCTGGTCATCG	0.443000													39	81					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095870	167095870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167095870G>A	ENST00000361200.2	+	6	1668	c.1502G>A	c.(1501-1503)aGa>aAa	p.R501K	DUSP27_ENST00000271385.5_Missense_Mutation_p.R501K|DUSP27_ENST00000443333.1_Missense_Mutation_p.R501K|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	501					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AAGAGCAAGAGAGAGGAGGCG	0.607000													19	40					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16230351	16230351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16230351C>T	ENST00000399408.2	+	30	4347	c.4172C>T	c.(4171-4173)tCg>tTg	p.S1391L	ABCC1_ENST00000351154.5_Missense_Mutation_p.S1322L|ABCC1_ENST00000346370.5_Missense_Mutation_p.S1325L|ABCC1_ENST00000349029.5_Missense_Mutation_p.S1266L|ABCC1_ENST00000345148.5_Missense_Mutation_p.S1381L|ABCC1_ENST00000399410.3_Missense_Mutation_p.S1381L			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1381	ABC transporter 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTTTTGTTTTCGGGTTCCCTC	0.562000													9	43					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23896924	23896924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23896924C>T	ENST00000355349.3	-	16	1920	c.1758G>A	c.(1756-1758)gtG>gtA	p.V586V		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	586	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGTTGTAGTCCACGATGCCGG	0.532000													26	70					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73490351	73490351	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73490351C>T	ENST00000224721.6	+	30	3725	c.3720C>T	c.(3718-3720)gaC>gaT	p.D1240D	C10orf105_ENST00000398786.2_Intron	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1235	Cadherin 12.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						AAGCCACAGACCGAGACTCTG	0.617000													9	43					0	0	1	0	0
FOXRED1	55572	broad.mit.edu	37	11	126143291	126143291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:126143291C>T	ENST00000263578.5	+	4	552	c.478C>T	c.(478-480)Ctc>Ttc	p.L160F	FOXRED1_ENST00000442061.2_5'UTR|FOXRED1_ENST00000532125.1_Missense_Mutation_p.L146F|FOXRED1_ENST00000534011.1_3'UTR	NM_017547.3	NP_060017.1	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing 1	160						integral to membrane|mitochondrion	oxidoreductase activity|protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	15	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		CTCGGGCTACCTCTTGCTGGC	0.567000													8	129					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107782025	107782025	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:107782025C>T	ENST00000311955.3	-	1	448	c.394G>A	c.(394-396)Gag>Aag	p.E132K		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	132					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GCATCCCTCTCGTACCTGTGG	0.542000													41	87					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147985774	147985774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:147985774G>A	ENST00000370460.2	+	9	1862	c.1383G>A	c.(1381-1383)agG>agA	p.R461R	AFF2_ENST00000370457.5_Silent_p.R428R|AFF2_ENST00000370458.1_Silent_p.R422R|AFF2_ENST00000342251.3_Silent_p.R428R|AFF2_ENST00000286437.5_Silent_p.R102R	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	461					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CAAAACCTAGGAATAATCCTG	0.323000													69	37					0	0	1	0	0
STIM2	57620	broad.mit.edu	37	4	27009158	27009158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:27009158C>T	ENST00000382009.3	+	8	1513	c.1246C>T	c.(1246-1248)Cgc>Tgc	p.R416C	STIM2_ENST00000465503.1_Missense_Mutation_p.R329C|STIM2_ENST00000237364.5_Missense_Mutation_p.R416C|STIM2_ENST00000412829.2_Missense_Mutation_p.R416C|STIM2_ENST00000467011.1_Missense_Mutation_p.R329C|STIM2_ENST00000467087.1_Missense_Mutation_p.R329C	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	329					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				cttcTAGGTTCGCATGGCTCT	0.383000													5	43					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42917072	42917072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42917072G>A	ENST00000316161.4	-	1	561	c.237C>T	c.(235-237)ttC>ttT	p.F79F	ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.F79F	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	79					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity	p.F79F(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		GGTCCATGACGAAGGTGAAGT	0.483000													19	47					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42059249	42059249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42059249C>T	ENST00000219905.7	+	24	9150	c.8969C>T	c.(8968-8970)gCc>gTc	p.A2990V	MGA_ENST00000389936.4_Missense_Mutation_p.A2951V|MGA_ENST00000570161.1_Missense_Mutation_p.A2990V|MGA_ENST00000545763.1_Missense_Mutation_p.A2781V|MGA_ENST00000566586.1_Missense_Mutation_p.A2781V	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2951						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CCAAAGTTGGCCCCTCTAGGT	0.512000													20	50					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116605974	116605974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116605974C>T	ENST00000369248.4	+	10	1581	c.1246C>T	c.(1246-1248)Cgc>Tgc	p.R416C	FAM160B1_ENST00000369250.3_Missense_Mutation_p.R416C	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	416										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						TCTGCTTCATCGCATCGTTCG	0.448000													89	206					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47117421	47117421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:47117421G>A	ENST00000562435.1	-	9	1673	c.1289C>T	c.(1288-1290)aCc>aTc	p.T430I	NETO2_ENST00000303155.5_Missense_Mutation_p.T423I	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2	430						integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				GCGGGAGGCGGTGGAGGAGCG	0.527000										HNSCC(25;0.065)			39	123					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123780052	123780052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123780052G>A	ENST00000223642.1	-	13	1614	c.1585C>T	c.(1585-1587)Cca>Tca	p.P529S		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	529					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TGTGTTACTGGAATGTTTATA	0.388000													20	60					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439377	110439377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110439377C>T	ENST00000378402.5	+	25	3096	c.2992C>T	c.(2992-2994)Ctt>Ttt	p.L998F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	998					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAAGCAGAATCTTCTACAGGT	0.473000										HNSCC(38;0.096)			12	20					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54159124	54159124	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:54159124A>G	ENST00000404125.1	-	10	1219	c.1164T>C	c.(1162-1164)ctT>ctC	p.L388L	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	388					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CTTGATCAGTAAGCTTGTGGC	0.443000													30	54					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072199	17072199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17072199G>A	ENST00000359963.3	-	1	1501	c.1242C>T	c.(1240-1242)gcC>gcT	p.A414A		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	414					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCATTTCTGTGGCCCCAGCTC	0.547000													25	60					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10420946	10420946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10420946C>T	ENST00000360273.2	-	9	1461	c.1023G>A	c.(1021-1023)gtG>gtA	p.V341V	ATP2B2_ENST00000352432.4_Silent_p.V341V|ATP2B2_ENST00000343816.4_Intron|ATP2B2_ENST00000397077.1_Intron|ATP2B2_ENST00000383800.4_Intron	NM_001001331.2	NP_001001331.1	Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	341					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GGCTGGCGTCCACATTGCCAT	0.517000													13	31					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33293903	33293903	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:33293903C>T	ENST00000280979.4	+	13	7054	c.6884C>T	c.(6883-6885)cCc>cTc	p.P2295L	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	2295					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GCATTGCATCCCAGCCCCAAA	0.433000													31	86					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17446125	17446125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17446125C>T	ENST00000400588.1	-	7	1429	c.1322G>A	c.(1321-1323)aGg>aAg	p.R441K		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	441										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				ATTGATGACCCTGTTGTTTCT	0.557000													10	37					0	0	1	0	0
CD300LB	124599	broad.mit.edu	37	17	72522001	72522001	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72522001T>A	ENST00000392621.1	-	2	371	c.367A>T	c.(367-369)Acg>Tcg	p.T123S	CD300LB_ENST00000314401.3_Missense_Mutation_p.T123S	NM_174892.2	NP_777552.2	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	86						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(1)	21						ACAGTGAACGTGCGGTCTTTC	0.522000													66	136					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676399	123676399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123676399G>A	ENST00000309154.2	-	1	696	c.659C>T	c.(658-660)tCt>tTt	p.S220F		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CAGGATGGTAGAAATTATGTA	0.488000													12	28					0	0	1	0	0
ICAM5	7087	broad.mit.edu	37	19	10403533	10403533	+	Missense_Mutation	SNP	C	C	T	rs140852122		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10403533C>T	ENST00000221980.4	+	5	1270	c.1207C>T	c.(1207-1209)Cgt>Tgt	p.R403C		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	403					cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CGCAGAGCTTCGTGTCCTATG	0.602000													14	59					0	0	1	0	0
ZNF597	146434	broad.mit.edu	37	16	3486680	3486680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3486680G>A	ENST00000301744.4	-	4	1254	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	LA16c-306E5.2_ENST00000575785.1_RNA	NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						acactgtaagggcttgaattt	0.463000													11	17					0	0	1	0	0
KLK12	43849	broad.mit.edu	37	19	51535261	51535261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51535261G>A	ENST00000525263.1	-	3	447	c.328C>T	c.(328-330)Cgg>Tgg	p.R110W	KLK12_ENST00000250352.11_Intron|KLK12_ENST00000319590.4_Missense_Mutation_p.R110W|CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000529888.1_Intron|KLK12_ENST00000250351.4_Missense_Mutation_p.R110W			Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	110	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		CGCAGCAGCCGGAGGTCGTGC	0.682000													10	20					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324495	152324495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152324495G>A	ENST00000388718.5	-	3	5839	c.5767C>T	c.(5767-5769)Cat>Tat	p.H1923Y	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1923							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCTGTCCATGAGTAGTTTGG	0.517000													63	263					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118306879	118306879	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118306879C>T	ENST00000369221.2	+	3	148	c.120C>T	c.(118-120)ccC>ccT	p.P40P	PNLIP_ENST00000470562.1_3'UTR	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	40					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CGGAAAGACCCCTCCATATAT	0.438000													22	107					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131191231	131191231	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:131191231C>T	ENST00000337057.3	-	15	2260	c.2079G>A	c.(2077-2079)aaG>aaA	p.K693K	EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000525193.1_Intron|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000531410.1_Intron|EPB41L2_ENST00000527659.1_Silent_p.K623K|EPB41L2_ENST00000528282.1_Intron|EPB41L2_ENST00000530481.1_Silent_p.K623K|EPB41L2_ENST00000445890.2_Intron|EPB41L2_ENST00000524581.1_Silent_p.K71K|EPB41L2_ENST00000527411.1_Silent_p.K623K|EPB41L2_ENST00000368128.2_Silent_p.K693K|EPB41L2_ENST00000529208.1_Silent_p.K623K	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	693					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CTGCCCGCTTCTTCTCCTCCA	0.408000													32	40					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47605684	47605684	+	Splice_Site	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47605684T>G	ENST00000273857.4	-	20	2541	c.2540_splice	c.e20-1	p.R848_splice	CORIN_ENST00000502252.1_Splice_Site_p.R781_splice|CORIN_ENST00000505909.1_Splice_Site_p.R811_splice|CORIN_ENST00000508498.1_Splice_Site_p.R709_splice	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	848	Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GCATTCTCTCTCCTAAAATTA	0.353000													4	41					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1801497	1801497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1801497G>A	ENST00000340107.4	+	4	659	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K	FGFR3_ENST00000352904.1_Missense_Mutation_p.E135K|FGFR3_ENST00000440486.2_Missense_Mutation_p.E135K|FGFR3_ENST00000412135.2_Missense_Mutation_p.E135K|FGFR3_ENST00000260795.2_Missense_Mutation_p.E135K|FGFR3_ENST00000481110.2_Missense_Mutation_p.E135K	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	135					bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGGAGATGACGAAGACGGGGA	0.682000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				5	42					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610231	47610231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47610231G>A	ENST00000371891.3	+	8	938	c.907G>A	c.(907-909)Ggg>Agg	p.G303R	CYP4A22_ENST00000485117.1_Intron|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000371890.3_Intron|CYP4A22_ENST00000294337.3_Missense_Mutation_p.G303R	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	303						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GATGGAGAATGGGAGCATCTT	0.537000													23	156					0	0	1	0	0
DAPP1	27071	broad.mit.edu	37	4	100738117	100738117	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100738117C>T	ENST00000296414.7	+	1	128	c.47C>T	c.(46-48)cCc>cTc	p.P16L	DAPP1_ENST00000512369.1_Missense_Mutation_p.P16L			Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and 3-phosphoinositides	16					signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity			endometrium(1)|kidney(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		ACCCAGGATCCCTCAGATCTG	0.552000													4	12					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7249425	7249425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7249425G>A	ENST00000266542.4	-	6	1118	c.1026C>T	c.(1024-1026)ctC>ctT	p.L342L	C1RL_ENST00000544702.1_3'UTR|C1RL_ENST00000504702.2_Intron|C1RL_ENST00000545280.1_Intron	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	342	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GCAGCTCCAGGAGGGCGATGT	0.602000													22	42					0	0	1	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48716111	48716111	+	Silent	SNP	G	G	A	rs34283811		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48716111G>A	ENST00000294129.2	-	12	1970	c.1851C>T	c.(1849-1851)ttC>ttT	p.F617F	NCKIPSD_ENST00000341520.4_Silent_p.F617F|NCKIPSD_ENST00000416649.2_Silent_p.F610F	NM_016453.2	NP_057537.1	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain	617					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGTCCTGCAGGAACTTGAGGA	0.572000													49	93					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66416266	66416266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:66416266G>A	ENST00000395625.2	-	3	311	c.47C>T	c.(46-48)tCc>tTc	p.S16F	MEGF11_ENST00000288745.3_Missense_Mutation_p.S16F|MEGF11_ENST00000395614.1_5'UTR|MEGF11_ENST00000360698.4_Silent_p.I57I|MEGF11_ENST00000409699.2_Silent_p.I57I|MEGF11_ENST00000422354.1_Silent_p.I57I			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	0						basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						ACCAGTTGAGGATGTCTGTGC	0.532000													17	92					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157931190	157931190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157931190G>A	ENST00000389413.3	-	7	1031	c.928C>T	c.(928-930)Ctc>Ttc	p.L310F	PTPRN2_ENST00000389416.4_Missense_Mutation_p.L293F|PTPRN2_ENST00000404321.2_Missense_Mutation_p.L333F|PTPRN2_ENST00000389418.4_Missense_Mutation_p.L310F|PTPRN2_ENST00000409483.1_Missense_Mutation_p.L272F	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	310						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TCCTTCAGGAGGGTATGAATC	0.617000													23	61					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1078005	1078005	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1078005C>T	ENST00000264930.5	-	12	1615	c.1572G>A	c.(1570-1572)acG>acA	p.T524T		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	524					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GCGGTGCCCCCGTGAGGCTCT	0.692000													4	15					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28864346	28864346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28864346C>T	ENST00000373833.6	+	13	1378	c.1093C>T	c.(1093-1095)Cgt>Tgt	p.R365C	RCC1_ENST00000373831.3_Missense_Mutation_p.R396C|RCC1_ENST00000373832.1_Missense_Mutation_p.R365C|RCC1_ENST00000398958.2_Missense_Mutation_p.R365C			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	365					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		TCTTGCAGGTCGTGTTTTCGC	0.592000													10	13					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4281431	4281431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4281431G>A	ENST00000404826.2	+	43	6276	c.6137G>A	c.(6136-6138)gGg>gAg	p.G2046E	SDK1_ENST00000389531.3_Missense_Mutation_p.G2026E|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2046					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTAGGAAAGGGGATCTCCACC	0.607000													8	30					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131976126	131976126	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131976126G>A	ENST00000356920.5	+	1	245	c.151G>A	c.(151-153)Gac>Aac	p.D51N	POTEE_ENST00000358087.5_Missense_Mutation_p.D51N|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	51							ATP binding										AGACCACGACGACTCTGCTAT	0.597000													24	340					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163819	32163819	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32163819G>A	ENST00000564145.1	-	0	15																											GCGGAGCTGGGAGTTGATGTA	0.527000													7	69					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48267725	48267725	+	Missense_Mutation	SNP	G	G	A	rs145307365		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48267725G>A	ENST00000225964.5	-	35	2532	c.2414C>T	c.(2413-2415)cCt>cTt	p.P805L		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	805	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GGGGGGACCAGGCTCACCACG	0.622000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						6	79					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791225	95791225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95791225C>T	ENST00000260766.3	+	2	1056	c.422C>T	c.(421-423)cCt>cTt	p.P141L	PLCE1_ENST00000371380.2_Missense_Mutation_p.P141L	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	141					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				ACTGGAATTCCTTCTCCACTG	0.413000													32	75					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84784977	84784977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:84784977G>A	ENST00000389394.3	+	11	1858	c.1721G>A	c.(1720-1722)gGa>gAa	p.G574E	DNAH6_ENST00000237449.6_Missense_Mutation_p.G574E|DNAH6_ENST00000398278.2_Missense_Mutation_p.G574E	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	574	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						AAACTTGAAGGAAAAACCTGT	0.358000													23	148					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326351	152326351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152326351C>T	ENST00000388718.5	-	3	3983	c.3911G>A	c.(3910-3912)gGa>gAa	p.G1304E	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1304							calcium ion binding|structural molecule activity	p.G1304A(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AACTGTGGATCCTGACTTTGG	0.478000													68	287					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29782300	29782300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:29782300C>T	ENST00000375398.2	-	23	4311	c.3862G>A	c.(3862-3864)Gtg>Atg	p.V1288M	SVIL_ENST00000535393.1_Missense_Mutation_p.V202M|SVIL_ENST00000355867.4_Missense_Mutation_p.V1288M|SVIL_ENST00000538146.1_Missense_Mutation_p.V80M|SVIL_ENST00000375400.3_Missense_Mutation_p.V862M			O95425	SVIL_HUMAN	supervillin	1288					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				ACAGTGAGCACCGTTTCGTGC	0.398000													16	32					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1058699	1058699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1058699C>T	ENST00000263094.6	+	38	5463	c.5232C>T	c.(5230-5232)ttC>ttT	p.F1744F	ABCA7_ENST00000433129.1_Silent_p.F1744F|ABCA7_ENST00000435683.2_Silent_p.F1606F	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1744					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCCCTCTTCCTTCTCTTCA	0.572000													42	115					0	0	1	0	0
PIWIL4	143689	broad.mit.edu	37	11	94341758	94341758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94341758C>T	ENST00000299001.6	+	15	2060	c.1849C>T	c.(1849-1851)Ctg>Ttg	p.L617L	RP11-867G2.8_ENST00000537874.1_RNA|RP11-867G2.8_ENST00000536540.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	617	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GTTAAAGTCCCTGATGGTGGT	0.403000													18	183					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735322	13735322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13735322G>A	ENST00000265104.4	-	68	11783	c.11679C>T	c.(11677-11679)ttC>ttT	p.F3893F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3893					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGGTGAACAGGAATTTGTGCT	0.433000									Kartagener syndrome				30	67					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80626663	80626663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:80626663G>A	ENST00000307624.3	-	14	1516	c.1488C>T	c.(1486-1488)ctC>ctT	p.L496L	ACOT12_ENST00000508234.1_5'UTR	NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	496	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TAGCATGGATGAGAAATCCGG	0.433000													6	69					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16475435	16475435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:16475435G>A	ENST00000334133.4	-	3	527	c.255C>T	c.(253-255)ttC>ttT	p.F85F	RFTN1_ENST00000432519.1_Silent_p.F49F	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	85						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						TGGGCTGCACGAAGGGGTGCA	0.642000													36	164					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75266120	75266120	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75266120C>T	ENST00000325680.7	+	5	4244	c.4120C>T	c.(4120-4122)Cga>Tga	p.R1374*	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Nonsense_Mutation_p.R1179*	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GTTGAGGATTCGAGAGTATCC	0.463000													46	202					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11580895	11580895	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11580895C>T	ENST00000294484.6	+	10	2490	c.2352C>T	c.(2350-2352)atC>atT	p.I784I	PTCHD2_ENST00000389575.3_Silent_p.I784I	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	784					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCTCCTGCATCACCTGTTCAG	0.637000													7	9					0	0	1	0	0
NPPA	4878	broad.mit.edu	37	1	11907192	11907192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11907192C>T	ENST00000376480.3	-	2	526	c.428G>A	c.(427-429)gGa>gAa	p.G143E	NPPA-AS1_ENST00000446542.1_RNA|NPPA_ENST00000376476.1_Missense_Mutation_p.G93E|NPPA-AS1_ENST00000400892.2_RNA	NM_006172.3	NP_006163.1	P01160	ANF_HUMAN	natriuretic peptide A	143					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACAGCCCAGTCCGCTCTGGGC	0.592000													128	301					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45671561	45671561	+	Silent	SNP	G	G	A	rs148926071		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45671561G>A	ENST00000270172.3	-	9	1197	c.714C>T	c.(712-714)ttC>ttT	p.F238F	DNMT3L_ENST00000418993.1_Silent_p.F238F	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	238					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding	p.F238F(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		ACACAAGATCGAAGGGTCCCC	0.652000													9	36					0	0	1	0	0
GPR27	2850	broad.mit.edu	37	3	71803825	71803825	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:71803825C>T	ENST00000304411.2	+	1	625	c.625C>T	c.(625-627)Cac>Tac	p.H209Y	EIF4E3_ENST00000421769.2_5'UTR	NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	209						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CTTCTTCATCCACGACCGCCG	0.761000													6	6					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154395491	154395491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154395491G>A	ENST00000435029.4	+	1	2232	c.2072G>A	c.(2071-2073)aGa>aAa	p.R691K		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	691	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAACTTGAAAGAAACTTCCAG	0.443000													45	93					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68747534	68747534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68747534C>T	ENST00000309106.3	-	1	921	c.922G>A	c.(922-924)Ggt>Agt	p.G308S		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	308						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTCTCCCCACCTTCCAGCTCG	0.672000													21	66					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81251698	81251698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81251698G>A	ENST00000555265.1	-	15	2127	c.1752C>T	c.(1750-1752)tcC>tcT	p.S584S	CEP128_ENST00000281129.3_Silent_p.S584S			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	584						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						TGGTATCCAGGGAATTCTTAA	0.438000													34	106					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17531718	17531718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17531718C>T	ENST00000375471.4	+	1	98	c.6C>T	c.(4-6)gcC>gcT	p.A2A		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	2					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	ACAGGATGGCCCCAAAGAGAG	0.587000													12	24					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97920544	97920544	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97920544C>T	ENST00000534948.1	+	0	5320							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		ACCATAATTACCAAGGAAAAG	0.363000													7	8					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214814107	214814107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:214814107C>T	ENST00000366955.3	+	12	2594	c.2426C>T	c.(2425-2427)tCa>tTa	p.S809L		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	809					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGCATGCCTTCAGAGAGGAGT	0.388000													17	42					0	0	1	0	0
UBXN2B	137886	broad.mit.edu	37	8	59345768	59345768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:59345768C>T	ENST00000399598.2	+	4	511	c.389C>T	c.(388-390)tCt>tTt	p.S130F	UBXN2B_ENST00000522978.1_3'UTR	NM_001077619.1	NP_001071087.1	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	130						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13						TGTAAGCGGTCTGAATATATC	0.308000													81	206					0	0	1	0	0
PLA2G2E	30814	broad.mit.edu	37	1	20249129	20249129	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20249129G>A	ENST00000375116.3	-	2	217	c.160C>T	c.(160-162)Ccg>Tcg	p.P54S		NM_014589.1	NP_055404.1	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE	54					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity	p.P54S(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTCCACCGGCCAGTGGGAG	0.612000													6	89					0	0	1	0	0
LCE2D	353141	broad.mit.edu	37	1	152636718	152636718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152636718C>T	ENST00000368784.1	+	2	192	c.137C>T	c.(136-138)tCc>tTc	p.S46F		NM_178430.2	NP_848517.1	Q5TA82	LCE2D_HUMAN	late cornified envelope 2D	46	Cys-rich.				keratinization					large_intestine(1)|lung(7)|prostate(2)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCAGTCTCTTCCTGCTGTGGT	0.632000													79	190					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155203411	155203411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155203411C>T	ENST00000460012.1	-	22	2975	c.2618G>A	c.(2617-2619)cGa>cAa	p.R873Q	PLCH1_ENST00000334686.6_Missense_Mutation_p.R873Q|PLCH1_ENST00000494598.1_Missense_Mutation_p.R891Q|PLCH1_ENST00000447496.2_Missense_Mutation_p.R911Q|PLCH1_ENST00000340059.7_Missense_Mutation_p.R911Q|PLCH1_ENST00000414191.1_Missense_Mutation_p.R873Q			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	911					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCAATGGATCGCTTCCGTAC	0.458000													17	64					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685369	100685369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100685369C>T	ENST00000306151.4	+	3	10736	c.10672C>T	c.(10672-10674)Cca>Tca	p.P3558S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3558	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTTCATCTCCAGCAACTCT	0.483000													45	398					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242151573	242151573	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242151573C>T	ENST00000274979.8	+	16	1891	c.1788C>T	c.(1786-1788)ttC>ttT	p.F596F	ANO7_ENST00000402430.3_Silent_p.F595F	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	596						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						TCTTCCAGTTCGTCAACTTCT	0.582000													41	77					0	0	1	0	0
WFDC11	259239	broad.mit.edu	37	20	44278037	44278037	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44278037C>T	ENST00000356562.2	-	4	323	c.100_splice	c.e4-1	p.R34_splice	WFDC11_ENST00000324384.3_Splice_Site_p.R34_splice			Q8NEX6	WFD11_HUMAN	WAP four-disulfide core domain 11	34						extracellular region				endometrium(1)|lung(4)	5		Myeloproliferative disorder(115;0.0122)				ACAATTCCTTCCCTGAAATTG	0.388000													41	139					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186292914	186292914	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186292914G>A	ENST00000367478.3	-	43	6497	c.6201C>T	c.(6199-6201)gcC>gcT	p.A2067A		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	2067					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GTGCTCGAGGGGCCTGTCTTT	0.517000			T	NTRK1	papillary thyroid								63	131					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30860294	30860294	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30860294C>T	ENST00000324771.8	+	10	1622	c.1074C>T	c.(1072-1074)ctC>ctT	p.L358L	DDR1_ENST00000508312.1_Silent_p.L376L|DDR1_ENST00000452441.1_Silent_p.L358L|DDR1_ENST00000376575.3_Silent_p.L358L|DDR1_ENST00000361741.4_Silent_p.L89L|DDR1_ENST00000376569.3_Silent_p.L358L|DDR1_ENST00000418800.2_Silent_p.L358L|DDR1_ENST00000376570.4_Silent_p.L358L|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000376568.3_Silent_p.L358L|DDR1_ENST00000376567.2_Silent_p.L358L|DDR1_ENST00000513240.1_Silent_p.L358L|DDR1_ENST00000454612.2_Silent_p.L358L			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	358					cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CCTGGTTACTCTTCAGCGAAA	0.587000													13	121					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38988326	38988326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38988326G>A	ENST00000302328.3	-	2	538	c.340C>T	c.(340-342)Cct>Tct	p.P114S	SCN11A_ENST00000456224.3_Missense_Mutation_p.P114S|SCN11A_ENST00000444237.2_Missense_Mutation_p.P114S|SCN11A_ENST00000450244.1_Missense_Mutation_p.P114S	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	114					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GAATTGAAAGGCCCAAAAATG	0.373000													36	84					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370697	240370697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240370697C>T	ENST00000319653.9	+	5	2815	c.2585C>T	c.(2584-2586)cCt>cTt	p.P862L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	862	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCACCTCTGCCTTGCACAGAG	0.572000													29	127					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35545003	35545003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35545003C>T	ENST00000536438.1	-	11	1349	c.1034G>A	c.(1033-1035)gGa>gAa	p.G345E	FKBP5_ENST00000357266.4_Missense_Mutation_p.G345E|FKBP5_ENST00000540787.1_Missense_Mutation_p.G166E|FKBP5_ENST00000539068.1_Missense_Mutation_p.G345E	NM_001145775.1	NP_001139247.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	345					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						ACTGTCCAGTCCAAGGGCCTA	0.433000													51	174					0	0	1	0	0
PAQR5	54852	broad.mit.edu	37	15	69689814	69689814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:69689814G>A	ENST00000340965.3	+	7	1188	c.520G>A	c.(520-522)Gaa>Aaa	p.E174K	RP11-253M7.1_ENST00000560539.1_RNA|PAQR5_ENST00000561153.1_Missense_Mutation_p.E174K|PAQR5_ENST00000395407.2_Missense_Mutation_p.E174K|RP11-253M7.1_ENST00000558617.1_RNA	NM_001104554.1	NP_001098024.1	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	174					cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(2)|ovary(2)|skin(1)	11						TAGGTTTCTTGAAATCCAGAA	0.502000													65	88					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712539	140712539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140712539C>T	ENST00000517417.1	+	1	2288	c.2288C>T	c.(2287-2289)tCg>tTg	p.S763L	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.S763L	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCGGACTCGCGGAAGAGC	0.592000													86	188					0	0	1	0	0
SEMA4C	54910	broad.mit.edu	37	2	97527334	97527334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97527334G>A	ENST00000305476.5	-	14	1786	c.1654C>T	c.(1654-1656)Ctc>Ttc	p.L552F		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	552					muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						CTGCCACGGAGGTTGCAGATG	0.562000													28	130					0	0	1	0	0
THAP4	51078	broad.mit.edu	37	2	242573389	242573389	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242573389G>A	ENST00000407315.1	-	2	614	c.183C>T	c.(181-183)acC>acT	p.T61T		NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	61							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		AGCTGTCTTTGGTGAAATGCT	0.512000													65	133					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733542	50733542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50733542G>A	ENST00000300589.2	+	2	322	c.217G>A	c.(217-219)Ggc>Agc	p.G73S	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	73	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GGACTACGAGGGCTTCCACCT	0.637000													27	60					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215928826	215928826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215928826G>A	ENST00000272895.7	-	3	499	c.280C>T	c.(280-282)Cgt>Tgt	p.R94C		NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	94					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CCTTTCCTACGAAGCAGATCT	0.433000													45	139					0	0	1	0	0
CYP4V2	285440	broad.mit.edu	37	4	187130354	187130354	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187130354T>A	ENST00000378802.4	+	10	1637	c.1333T>A	c.(1333-1335)Ttc>Atc	p.F445I	CYP4V2_ENST00000502665.1_3'UTR	NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	445					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		TGAGCGGTTCTTCCCCGAGAA	0.527000													37	117					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6685009	6685009	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6685009C>T	ENST00000245907.6	-	30	4051	c.3959G>A	c.(3958-3960)cGa>cAa	p.R1320Q		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1320		Cleavage; by factor I.	R -> Q (in C3D; allotype C3'F02'; may inhibit IC3B synthesis).		complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCTTCTGATCGCAGGAGGCT	0.597000													12	41					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121414281	121414281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121414281C>T	ENST00000260197.7	+	13	1839	c.1710C>T	c.(1708-1710)acC>acT	p.T570T	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	570					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AAGGGGAGACCTGGAAAACAT	0.458000													26	111					0	0	1	0	0
UNCX	340260	broad.mit.edu	37	7	1275593	1275593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:1275593C>T	ENST00000316333.8	+	3	687	c.576C>T	c.(574-576)atC>atT	p.I192I		NM_001080461.1	NP_001073930.1	A6NJT0	UNC4_HUMAN	UNC homeobox	192					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|skin(1)|upper_aerodigestive_tract(1)	4		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		CGGAGGAGATCGCGCGCAAGG	0.652000													7	17					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102742443	102742443	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102742443C>T	ENST00000532855.1	-	0	602							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	ATGGAAGTCTCCATGAGCTTT	0.443000													5	14					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175372323	175372323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175372323C>T	ENST00000367674.1	-	4	1637	c.929G>A	c.(928-930)gGg>gAg	p.G310E	TNR_ENST00000263525.2_Missense_Mutation_p.G310E	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	310	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GACGCAGAGCCCCTCCTCACA	0.612000													15	58					0	0	1	0	0
TTLL13P	440307	broad.mit.edu	37	15	90793899	90793899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90793899G>A	ENST00000561573.1	+	2	301	c.37G>A	c.(37-39)Gaa>Aaa	p.E13K	TTLL13_ENST00000438251.1_Missense_Mutation_p.E13K|TTLL13_ENST00000339615.5_Missense_Mutation_p.E13K																							GGAATCAGAGGAAGACTATGT	0.473000													32	48					0	0	1	0	0
CLDN1	9076	broad.mit.edu	37	3	190039867	190039867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:190039867G>A	ENST00000295522.3	-	1	397	c.129C>T	c.(127-129)gcC>gcT	p.A43A		NM_021101.4	NP_066924.1	O95832	CLD1_HUMAN	claudin 1	43					calcium-independent cell-cell adhesion|interspecies interaction between organisms	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity			lung(9)	9	all_cancers(143;2.95e-10)|Ovarian(172;0.0512)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.015)		ACATGGCCTGGGCGGTCACGA	0.592000													25	91					0	0	1	0	0
DHH	50846	broad.mit.edu	37	12	49483723	49483723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49483723G>A	ENST00000266991.2	-	3	1416	c.1110C>T	c.(1108-1110)ctC>ctT	p.L370L		NM_021044.2	NP_066382.1	O43323	DHH_HUMAN	desert hedgehog	370					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			breast(1)|large_intestine(3)|lung(4)	8						CCCCGCCGGGGAGCAGCGCCC	0.652000													3	6					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436710	56436710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:56436710C>T	ENST00000327381.5	+	3	1977	c.1877C>T	c.(1876-1878)tCc>tTc	p.S626F		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	626						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TTTGAATGTTCCCCATCTCCT	0.453000													24	55					0	0	1	0	0
OFCC1	266553	broad.mit.edu	37	6	9933535	9933535	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:9933535G>A	ENST00000316020.6	-	3	222	c.223C>T	c.(223-225)Cag>Tag	p.Q75*	OFCC1_ENST00000472329.1_5'UTR					orofacial cleft 1 candidate 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)	11	Ovarian(93;0.0473)|Breast(50;0.201)	all_hematologic(90;0.124)				GCCTTCTGCTGAAACTTCTGG	0.363000													17	66					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57963926	57963926	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57963926A>T	ENST00000455537.2	+	12	1548	c.1274A>T	c.(1273-1275)tAt>tTt	p.Y425F	KIF5A_ENST00000286452.5_Missense_Mutation_p.Y336F	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	425					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CGCCGTCTCTATAAGCAGCTT	0.572000													7	16					0	0	1	0	0
U66061.31	0	broad.mit.edu	37	7	142423749	142423749	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142423749G>A	ENST00000506718.1	+	0	757																											CAAGAACAAGGAGACTCCTCC	0.547000													8	20					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18788653	18788653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18788653G>A	ENST00000406451.3	+	14	2076	c.1926G>A	c.(1924-1926)ctG>ctA	p.L642L	HDAC9_ENST00000441542.2_Silent_p.L645L|HDAC9_ENST00000432645.2_Silent_p.L642L|HDAC9_ENST00000401921.1_Silent_p.L601L	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	642	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CCTTGATGCTGAAACACCAGT	0.438000													11	22					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142658103	142658103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142658103G>A	ENST00000355265.2	-	4	786	c.312C>T	c.(310-312)ttC>ttT	p.F104F	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	104					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AGGCAAAGCTGAAGAAGTCGG	0.512000													35	136					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982196	7982196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7982196C>T	ENST00000328600.2	-	2	1124	c.963G>A	c.(961-963)gcG>gcA	p.A321A		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	321	NACHT.						ATP binding	p.A321A(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGAAGTACCTCGCCCTCTCCT	0.512000													40	93					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141600150	141600150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141600150C>T	ENST00000442267.2	-	5	871	c.797G>A	c.(796-798)cGa>cAa	p.R266Q		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	266						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				GGGCAGGGATCGATCTTGTTC	0.418000													71	150					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21899156	21899156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21899156G>A	ENST00000399982.2	-	1	711	c.647C>T	c.(646-648)tCc>tTc	p.S216F	CHD8_ENST00000557364.1_Missense_Mutation_p.S216F|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Intron	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	216					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGAGACAATGGAAACACCTGG	0.567000													7	32					0	0	1	0	0
GLS	2744	broad.mit.edu	37	2	191795172	191795172	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:191795172C>T	ENST00000320717.3	+	13	1693	c.1435C>T	c.(1435-1437)Cct>Tct	p.P479S	GLS_ENST00000338435.4_Missense_Mutation_p.P479S|GLS_ENST00000409626.1_Missense_Mutation_p.P50S|GLS_ENST00000409428.1_5'UTR|GLS_ENST00000409215.1_5'UTR	NM_014905.4	NP_055720.3	O94925	GLSK_HUMAN	glutaminase	479					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	16			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGTTGGTCTTCCTGCAAAATC	0.408000													15	67					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238277484	238277484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238277484G>A	ENST00000295550.4	-	10	5074	c.4622C>T	c.(4621-4623)cCc>cTc	p.P1541L	COL6A3_ENST00000409809.1_Missense_Mutation_p.P1335L|COL6A3_ENST00000472056.1_Missense_Mutation_p.P934L|COL6A3_ENST00000346358.4_Missense_Mutation_p.P1341L|COL6A3_ENST00000353578.4_Missense_Mutation_p.P1335L|COL6A3_ENST00000347401.3_Missense_Mutation_p.P1340L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1541	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CAGGTGTTGGGGCACCCCGTC	0.572000													38	88					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120809324	120809324	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:120809324G>A	ENST00000369144.3	-	17	2774	c.2647C>T	c.(2647-2649)Ctt>Ttt	p.L883F	EIF3A_ENST00000541549.1_Missense_Mutation_p.L849F|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	883					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TTTCTAGAAAGGGAACTATCG	0.403000													72	183					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202291	56202291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56202291C>T	ENST00000361673.3	-	5	5341	c.5128G>A	c.(5128-5130)Gag>Aag	p.E1710K		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1710							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTCTTGACCTCCTCTGACCCC	0.567000													38	117					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059369	248059369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248059369C>T	ENST00000537741.1	+	3	738	c.481C>T	c.(481-483)Cct>Tct	p.P161S	OR2W3_ENST00000360358.3_Missense_Mutation_p.P161S			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCCATGTCTCCTGTGACCCT	0.647000													29	65					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003483	122003483	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122003483C>T	ENST00000498619.1	+	7	3150	c.2712C>T	c.(2710-2712)gtC>gtT	p.V904V	CASR_ENST00000296154.5_Silent_p.V894V|CASR_ENST00000490131.1_Silent_p.V894V	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	894					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCAGCAACGTCTCCCGCAAGC	0.652000													21	33					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88482261	88482261	+	Silent	SNP	C	C	T	rs148640386		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:88482261C>T	ENST00000324166.5	+	5	2537	c.846C>T	c.(844-846)gtC>gtT	p.V282V	THNSL2_ENST00000496844.1_3'UTR|THNSL2_ENST00000449349.1_Intron|THNSL2_ENST00000358591.2_Silent_p.V282V|THNSL2_ENST00000377254.3_Silent_p.V282V|THNSL2_ENST00000343544.4_Silent_p.V282V|THNSL2_ENST00000402102.1_Silent_p.V282V	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	282					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						TCCGTCTGGTCGTGGCAGTGA	0.463000													15	63					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35247748	35247748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:35247748G>A	ENST00000381318.3	+	34	4552	c.4264G>A	c.(4264-4266)Gaa>Aaa	p.E1422K	ITSN1_ENST00000381285.4_Missense_Mutation_p.E1422K|ITSN1_ENST00000399367.3_Missense_Mutation_p.E1417K|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000399326.3_3'UTR|ITSN1_ENST00000437442.2_Intron	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	1422	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						CCAGGTGAACGAAGGGGTGCG	0.607000													37	93					0	0	1	0	0
SLC24A4	123041	broad.mit.edu	37	14	92905734	92905734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92905734C>T	ENST00000532405.1	+	4	600	c.374C>T	c.(373-375)tCt>tTt	p.S125F	SLC24A4_ENST00000393265.2_Missense_Mutation_p.S61F|SLC24A4_ENST00000298877.1_Missense_Mutation_p.S108F|SLC24A4_ENST00000531433.1_Missense_Mutation_p.S125F|SLC24A4_ENST00000351924.5_Missense_Mutation_p.S108F			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	125						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		TTTGTTCCGTCTCTAGAGAAG	0.527000													31	133					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150828306	150828306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150828306C>T	ENST00000370357.4	+	10	1084	c.839C>T	c.(838-840)cCa>cTa	p.P280L		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	280						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGAATCTCCAGGTAGGTAC	0.373000													31	44					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278658	36278658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36278658C>T	ENST00000007510.4	+	21	3335	c.3191C>T	c.(3190-3192)tCc>tTc	p.S1064F	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.S900F|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.S903F			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1064					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CAGCCCAGTTCCCCAGCCCCA	0.667000													10	84					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75248676	75248676	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75248676C>T	ENST00000325680.7	+	4	2054	c.1930C>T	c.(1930-1932)Cct>Tct	p.P644S	YLPM1_ENST00000552421.1_Missense_Mutation_p.P644S|YLPM1_ENST00000238571.3_Missense_Mutation_p.P449S	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	449					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGGGATACCTCCTCAGTTAAC	0.547000													23	55					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52571623	52571623	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52571623G>T	ENST00000591504.1	-	12	1248	c.974C>A	c.(973-975)tCc>tAc	p.S325Y	CCDC68_ENST00000432185.1_Missense_Mutation_p.S325Y|CCDC68_ENST00000337363.4_Missense_Mutation_p.S325Y	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	325										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TAAATAAGGGGAAACACCTTC	0.378000													15	58					1.02788e-11	1.03238e-11	1	1	0
SLC39A1	27173	broad.mit.edu	37	1	153932928	153932928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153932928G>A	ENST00000368623.3	-	3	1380	c.621C>T	c.(619-621)gcC>gcT	p.A207A	SLC39A1_ENST00000356205.4_Silent_p.A207A|SLC39A1_ENST00000537590.1_Silent_p.A105A|SLC39A1_ENST00000310483.6_Silent_p.A207A|SLC39A1_ENST00000368621.1_Silent_p.A207A			Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter), member 1	207						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		ACAGCTCCATGGCCCGAGCCC	0.667000													16	35					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76812818	76812818	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76812818G>A	ENST00000286719.7	-	4	580	c.224C>T	c.(223-225)cCc>cTc	p.P75L		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	75					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GTGGCTGCTGGGGATGAAGTG	0.517000													85	221					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16008341	16008341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16008341G>A	ENST00000221700.5	-	2	176	c.81C>T	c.(79-81)gcC>gcT	p.A27A	CYP4F2_ENST00000592328.1_Silent_p.A27A|CYP4F2_ENST00000011989.7_5'UTR	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	27					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GGAGCCAGGAGGCCCCGACCA	0.647000													21	80					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84811201	84811201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:84811201C>T	ENST00000389394.3	+	15	2445	c.2308C>T	c.(2308-2310)Cct>Tct	p.P770S	DNAH6_ENST00000237449.6_Missense_Mutation_p.P770S|DNAH6_ENST00000398278.2_Missense_Mutation_p.P770S	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	770	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						GCCCACACCTCCTGAAGACTT	0.398000													36	133					0	0	1	0	0
TTC39A	22996	broad.mit.edu	37	1	51771684	51771684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:51771684C>T	ENST00000262676.5	-	7	809	c.649G>A	c.(649-651)Gga>Aga	p.G217R	TTC39A_ENST00000262675.7_Missense_Mutation_p.G158R|TTC39A_ENST00000447632.2_Missense_Mutation_p.G221R|TTC39A_ENST00000451380.1_Missense_Mutation_p.G185R|TTC39A_ENST00000371747.3_Missense_Mutation_p.G220R|TTC39A_ENST00000371750.5_Missense_Mutation_p.G186R|TTC39A_ENST00000413473.2_Missense_Mutation_p.G189R			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	221							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						TTCACTCCTCCTTCAAAGTGC	0.562000													34	78					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109766349	109766349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:109766349G>A	ENST00000399132.1	-	29	2104	c.1574C>T	c.(1573-1575)cCt>cTt	p.P525L	COL25A1_ENST00000399127.1_Missense_Mutation_p.P498L|COL25A1_ENST00000399126.1_Missense_Mutation_p.P525L	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	525						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		ACTTACAGAAGGACCCTGTGG	0.453000													70	184					0	0	1	0	0
FAM198B	51313	broad.mit.edu	37	4	159092037	159092037	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:159092037G>C	ENST00000296530.8	-	2	1112	c.491C>G	c.(490-492)cCt>cGt	p.P164R	FAM198B_ENST00000393807.5_Missense_Mutation_p.P164R|RP11-597D13.9_ENST00000503611.1_RNA|FAM198B_ENST00000592057.1_Missense_Mutation_p.P164R|FAM198B_ENST00000589306.1_Intron|FAM198B_ENST00000585682.1_Missense_Mutation_p.P164R	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	164						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						AGCGTACCCAGGTGCTACAGC	0.632000											OREG0016378	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	56					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58209029	58209029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58209029G>A	ENST00000377918.3	+	1	2375	c.2349G>A	c.(2347-2349)atG>atA	p.M783I		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	783					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGAACGTCATGAACGTGGTGA	0.587000													5	32					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55136211	55136211	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55136211C>T	ENST00000314706.3	+	1	852	c.852C>T	c.(850-852)ttC>ttT	p.F284F		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						CCTGTATCTTCTTGTATGCAA	0.408000													79	257					0	0	1	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45993752	45993752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45993752C>T	ENST00000400374.3	+	1	147	c.117C>T	c.(115-117)ccC>ccT	p.P39P	TSPEAR_ENST00000323084.4_Intron	NM_198687.1	NP_941960.1	P60372	KR104_HUMAN	keratin associated protein 10-4	39	36 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(1)	18						GCTGCGAGCCCCCCTGCTGCG	0.701000													7	66					0	0	1	0	0
SLC45A2	51151	broad.mit.edu	37	5	33964098	33964098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33964098G>A	ENST00000382102.3	-	3	643	c.586C>T	c.(586-588)Ctt>Ttt	p.L196F	SLC45A2_ENST00000509381.1_Intron|SLC45A2_ENST00000296589.4_Missense_Mutation_p.L196F|SLC45A2_ENST00000342059.3_Missense_Mutation_p.L137F|SLC45A2_ENST00000345083.5_Intron	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	196					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						GCACCCAAAAGGTAACCCAGG	0.458000													8	28					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	124979297	124979297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:124979297C>T	ENST00000431078.1	+	2	462	c.98C>T	c.(97-99)cCa>cTa	p.P33L		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	33	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGTGATGATCCACTAGCATCC	0.448000													4	14					0	0	1	0	0
RPL12P38	645688	broad.mit.edu	37	17	58512655	58512655	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58512655C>T	ENST00000588627.1	-	0	702																											ACCTTCTCTCCCTTCTTTGCA	0.498000													14	43					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12192799	12192799	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12192799G>A	ENST00000432424.2	+	0	919							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TCATTGAACAGACATACTACC	0.438000													7	29					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333020	70333020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70333020G>A	ENST00000338508.4	-	32	3380	c.3381C>T	c.(3379-3381)ttC>ttT	p.F1127F	SHANK2_ENST00000449833.2_Silent_p.F531F|SHANK2_ENST00000423696.2_Silent_p.F747F|SHANK2_ENST00000409161.1_Silent_p.F530F			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	747					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCTCCTCGGGGAACATGGAGG	0.667000													14	45					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976675	38976675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38976675G>A	ENST00000355481.4	+	34	5511	c.5380G>A	c.(5380-5382)Gcc>Acc	p.A1794T	RYR1_ENST00000360985.3_Missense_Mutation_p.A1794T|RYR1_ENST00000359596.3_Missense_Mutation_p.A1794T	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1794	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCAGCAGAGGCCCCGGCCCG	0.716000													17	40					0	0	1	0	0
HTR1E	3354	broad.mit.edu	37	6	87725215	87725215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:87725215C>T	ENST00000305344.4	+	2	866	c.163C>T	c.(163-165)Cag>Tag	p.Q55*	HTR1E_ENST00000369584.1_Nonsense_Mutation_p.Q55*	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	55					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GAAGCTCCACCAGCCTGCCAA	0.542000													25	44					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4277346	4277346	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4277346C>T	ENST00000404826.2	+	42	6199	c.6060C>T	c.(6058-6060)atC>atT	p.I2020I	SDK1_ENST00000389531.3_Silent_p.I2000I|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2020					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCAGCCTGATCGTCATCCTGC	0.567000													27	85					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258375	56258375	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56258375C>T	ENST00000327216.2	-	1	496	c.472G>A	c.(472-474)Gag>Aag	p.E158K		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					CACATGGTCTCCATCAGGCCA	0.512000													36	94					0	0	1	0	0
ESYT2	57488	broad.mit.edu	37	7	158528282	158528282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:158528282G>A	ENST00000251527.5	-	20	2563	c.2498C>T	c.(2497-2499)tCg>tTg	p.S833L	ESYT2_ENST00000435514.2_Missense_Mutation_p.S268L	NM_020728.2	NP_065779.1	A0FGR8	ESYT2_HUMAN	extended synaptotagmin-like protein 2	861	C2 3.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(16)|prostate(2)	32						TTCTGGTAACGAAACACTGAA	0.438000													56	124					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71491387	71491387	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71491387C>T	ENST00000296755.7	+	5	2503	c.2205C>T	c.(2203-2205)ctC>ctT	p.L735L		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	735	Lys-rich (highly basic, contains many KKEE and KKEI/V repeats).					microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTAAGAAGCTCCCTAAAGACG	0.388000													37	65					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88307707	88307707	+	Silent	SNP	G	G	A	rs142829279		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:88307707G>A	ENST00000357081.3	-	3	198	c.54C>T	c.(52-54)atC>atT	p.I18I	AGTPBP1_ENST00000337006.4_5'UTR|AGTPBP1_ENST00000376109.3_Silent_p.I70I|AGTPBP1_ENST00000376083.3_Silent_p.I18I|AGTPBP1_ENST00000491784.1_5'UTR|AGTPBP1_ENST00000376081.4_Silent_p.I18I			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	18					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						GGAGTCCTACGATCCTAGAAT	0.383000													16	63					0	0	1	0	0
DAZL	1618	broad.mit.edu	37	3	16636058	16636058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:16636058C>T	ENST00000250863.8	-	8	950	c.663G>A	c.(661-663)agG>agA	p.R221R	DAZL_ENST00000399444.2_Silent_p.R201R	NM_001190811.1	NP_001177740.1	Q92904	DAZL_HUMAN	deleted in azoospermia-like	201					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity		RAF1/DAZL(2)	endometrium(1)|large_intestine(3)|lung(4)|prostate(3)	11						CAACATAGCTCCTTTGCTCCC	0.308000													18	31					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8615558	8615558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8615558C>T	ENST00000338257.8	-	9	1059	c.792G>A	c.(790-792)ggG>ggA	p.G264G		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	264	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						TGGGCGGGATCCCAATAACCT	0.602000													24	77					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132237666	132237666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132237666G>A	ENST00000321253.6	+	4	507	c.400G>A	c.(400-402)Ggc>Agc	p.G134S	TUBA3D_ENST00000409047.2_3'UTR	NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	134					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		AGGACTGCAGGGCTTCCTCAT	0.587000													18	92					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38990420	38990420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:38990420G>A	ENST00000318792.1	+	2	224	c.214G>A	c.(214-216)Gat>Aat	p.D72N		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	72										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		tctgggAGAAGATGCTTCCCT	0.498000													21	42					0	0	1	0	0
C12orf54	121273	broad.mit.edu	37	12	48884612	48884612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48884612G>A	ENST00000314014.2	+	6	317	c.186G>A	c.(184-186)cgG>cgA	p.R62R	RP11-722P11.4_ENST00000551847.1_RNA|C12orf54_ENST00000548364.1_Silent_p.R62R	NM_152319.3	NP_689532.1	Q6X4T0	CL054_HUMAN	chromosome 12 open reading frame 54	62										endometrium(1)|large_intestine(4)	5						AAGATGCTCGGATTCGAGGTA	0.433000													51	105					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024324	76024324	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76024324C>T	ENST00000393004.2	-	5	1445	c.1224G>A	c.(1222-1224)agG>agA	p.R408R	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Silent_p.R408R|FILIP1_ENST00000370020.1_Silent_p.R309R			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	408										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GCAGCTTCTTCCTCAATTCCC	0.428000													14	152					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60549101	60549101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:60549101C>T	ENST00000373886.3	+	7	684	c.680C>T	c.(679-681)tCt>tTt	p.S227F		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	227					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						AATTCCCCCTCTATTCAGCAT	0.403000													44	98					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24578598	24578598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24578598C>T	ENST00000319715.4	+	15	2156	c.1724C>T	c.(1723-1725)cCt>cTt	p.P575L	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Missense_Mutation_p.P575L	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	575					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		cttcctctccctccgggtgtt	0.577000													45	179					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424120	56424120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56424120G>A	ENST00000588751.1	-	5	1087	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S	NLRP13_ENST00000342929.3_Missense_Mutation_p.P355S			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	355	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTAGCCAGGGGAACCAATTCT	0.473000													35	84					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209165796	209165796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:209165796C>T	ENST00000264380.4	+	9	1344	c.1186C>T	c.(1186-1188)Cga>Tga	p.R396*	PIKFYVE_ENST00000308862.6_Nonsense_Mutation_p.R310*|PIKFYVE_ENST00000392202.3_Nonsense_Mutation_p.R299*|PIKFYVE_ENST00000407449.1_Nonsense_Mutation_p.R396*	NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	396	DEP.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding	p.R396*(1)		NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						CTGGCTAATCCGAAATGGGCA	0.388000													15	63					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059716	152059716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152059716C>T	ENST00000368806.1	-	3	506	c.442G>A	c.(442-444)Gaa>Aaa	p.E148K		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	148							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GCTCCACTTTCTTCAGGGATG	0.468000													36	84					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205133001	205133001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205133001G>A	ENST00000367162.3	-	4	1437	c.1407C>T	c.(1405-1407)atC>atT	p.I469I	DSTYK_ENST00000367161.3_Silent_p.I469I|DSTYK_ENST00000367160.4_Intron	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	469						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						TAAGTCGGGAGATGATGAGTT	0.507000													15	107					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32500794	32500794	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32500794C>T	ENST00000266088.4	+	14	1937	c.1687C>T	c.(1687-1689)Ctg>Ttg	p.L563L	SLC5A1_ENST00000543737.1_Silent_p.L436L	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	563					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						GTGTTGGAGCCTGCGCAACAG	0.498000													11	57					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2306249	2306249	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:2306249G>A	ENST00000290974.2	-	8	2157	c.1818C>T	c.(1816-1818)gcC>gcT	p.A606A	RP11-478C1.7_ENST00000510632.1_RNA|ZFYVE28_ENST00000515312.1_Silent_p.A536A|ZFYVE28_ENST00000511071.1_Silent_p.A576A	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	606					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GTCTCTCAGGGGCCCTGTCGC	0.677000													8	43					0	0	1	0	0
LILRB3	11025	broad.mit.edu	37	19	54722248	54722248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54722248C>T	ENST00000391750.1	-	12	1711	c.1575G>A	c.(1573-1575)agG>agA	p.R525R	LILRA6_ENST00000419410.2_Silent_p.R525R|LILRA6_ENST00000391735.3_Intron|LILRB3_ENST00000245620.9_Silent_p.R525R|LILRB3_ENST00000407860.2_Silent_p.R542R|LILRA6_ENST00000270464.5_Silent_p.R525R|LILRB3_ENST00000346401.6_Silent_p.R537R|LILRB3_ENST00000469273.1_5'UTR|LILRB3_ENST00000424807.1_Silent_p.R525R|LILRA6_ENST00000440558.2_Silent_p.R525R			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	525				R -> G (in Ref. 2; AAB87667).	cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCAGCTCCACCCTGTCCTCAG	0.617000													18	76					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124369665	124369665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124369665G>A	ENST00000360013.3	+	38	5799	c.5672G>A	c.(5671-5673)gGa>gAa	p.G1891E	KALRN_ENST00000428018.2_Missense_Mutation_p.G162E|KALRN_ENST00000291478.4_Missense_Mutation_p.G194E|KALRN_ENST00000393496.1_Missense_Mutation_p.G232E|KALRN_ENST00000459915.1_5'UTR	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1890					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGTCTAGAAGGAAGCTCATAC	0.498000													28	101					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615326	179615326	+	Missense_Mutation	SNP	G	G	A	rs142848087		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179615326G>A	ENST00000360870.5	-	46	12023	c.11801C>T	c.(11800-11802)tCt>tTt	p.S3934F	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9751							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCGAAAAGAATTTTCAAA	0.338000													12	27					0	0	1	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54107574	54107574	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54107574G>A	ENST00000548263.1	-	13	1750	c.1702C>T	c.(1702-1704)Cga>Tga	p.R568*	CALCOCO1_ENST00000262059.4_Nonsense_Mutation_p.R568*|CALCOCO1_ENST00000550804.1_Nonsense_Mutation_p.R568*|CALCOCO1_ENST00000430117.2_Nonsense_Mutation_p.R483*			Q9P1Z2	CACO1_HUMAN	calcium binding and coiled-coil domain 1	568	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	28						GAAGCCTCTCGAGGCCCAGCA	0.607000													10	119					0	0	1	0	0
RDH16	8608	broad.mit.edu	37	12	57345840	57345840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57345840G>A	ENST00000398138.3	-	4	1783	c.927C>T	c.(925-927)gtC>gtT	p.V309V	RDH16_ENST00000360752.4_5'UTR	NM_003708.3	NP_003699.3	O75452	RDH16_HUMAN	retinol dehydrogenase 16 (all-trans)	309					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)	16						GGCTTGGAGAGACCCAGTACA	0.547000													14	44					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79414146	79414146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79414146C>T	ENST00000307745.7	+	15	3248	c.3248C>T	c.(3247-3249)cCt>cTt	p.P1083L																								CTCGAGGACCCTGAAACTATG	0.662000													24	61					0	0	1	0	0
ABCE1	6059	broad.mit.edu	37	4	146029175	146029175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:146029175C>T	ENST00000296577.4	+	4	713	c.198C>T	c.(196-198)ccC>ccT	p.P66P	ABCE1_ENST00000502803.1_Intron	NM_001040876.1|NM_002940.2	NP_001035809.1|NP_002931.2	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E (OABP), member 1	66	4Fe-4S ferredoxin-type 2.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|lung(5)|prostate(2)|skin(3)	18	all_hematologic(180;0.151)					AGAAATGCCCCTTTGGCGCCT	0.294000													19	44					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842129	5842129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5842129G>A	ENST00000317037.2	+	1	586	c.564G>A	c.(562-564)aaG>aaA	p.K188K	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTGGCCAAGGTATCCTGTG	0.478000													50	209					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11725334	11725334	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11725334G>A	ENST00000262442.3	+	46	8873	c.8805G>A	c.(8803-8805)gaG>gaA	p.E2935E	DNAH9_ENST00000454412.2_Silent_p.E2935E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2935	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACAACAGAGAGAACTGTTGGA	0.478000													18	25					0	0	1	0	0
TRAV38-1	28644	broad.mit.edu	37	14	22740410	22740410	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22740410G>A	ENST00000390464.2	+	0	317																											TCACAGCTGGGGGACACTGCG	0.473000													17	47					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361307	107361307	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107361307G>A	ENST00000374779.2	-	1	481	c.388C>T	c.(388-390)Ctg>Ttg	p.L130L		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						GGATATCTCAGAGGGTTGCAG	0.512000													18	86					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67685211	67685211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67685211C>T	ENST00000334583.6	+	23	2634	c.2306C>T	c.(2305-2307)tCt>tTt	p.S769F	RLTPR_ENST00000545661.1_Missense_Mutation_p.S733F	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	769										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GCCAACTTCTCTCTCAGCGTG	0.612000													26	62					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178553105	178553105	+	Missense_Mutation	SNP	G	G	A	rs145330384		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178553105G>A	ENST00000251582.7	-	18	2745	c.2644C>T	c.(2644-2646)Cgc>Tgc	p.R882C		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	882	TSP type-1 2.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		AGCCTCCGGCGGCAGCCATAC	0.657000													39	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085995	9085995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9085995G>A	ENST00000397910.4	-	1	6023	c.5820C>T	c.(5818-5820)tcC>tcT	p.S1940S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1940	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCACTGGAATGGATGAAAAAG	0.488000													12	34					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20512748	20512748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20512748C>T	ENST00000504154.1	+	11	1298	c.1046C>T	c.(1045-1047)tCt>tTt	p.S349F	SLIT2_ENST00000273739.5_Missense_Mutation_p.S353F|SLIT2_ENST00000503823.1_Missense_Mutation_p.S349F|SLIT2_ENST00000503837.1_Missense_Mutation_p.S353F	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	349					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GGACTACGCTCTCTGAATTCA	0.383000													22	68					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135647	55135647	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55135647C>T	ENST00000314706.3	+	1	288	c.288C>T	c.(286-288)ttC>ttT	p.F96F		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						CTTTATCATTCATAGATACCG	0.433000													53	160					0	0	1	0	0
IGLV2-11	28816	broad.mit.edu	37	22	23135302	23135302	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23135302C>T	ENST00000390314.2	+	0	206																											AACTATGTCTCCTGGTACCAA	0.552000													168	397					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6520073	6520073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6520073G>A	ENST00000377828.1	+	13	2600	c.2432G>A	c.(2431-2433)cGa>cAa	p.R811Q	ESPN_ENST00000461727.1_Missense_Mutation_p.R245Q|ESPN_ENST00000475228.1_3'UTR|ESPN_ENST00000416731.1_Missense_Mutation_p.R245Q	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	811	Glu-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		GAGGAGGAGCGACAGAAGCAG	0.662000													8	29					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43441296	43441296	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43441296G>A	ENST00000446844.3	-	0	22				PSG7_ENST00000406070.2_RNA|PSG7_ENST00000471557.1_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				CCTGAGCACGGCTGTCAGCTG	0.617000													16	35					0	0	1	0	0
APP	351	broad.mit.edu	37	21	27284094	27284094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:27284094G>A	ENST00000358918.3	-	14	2067	c.1868C>T	c.(1867-1869)tCt>tTt	p.S623F	APP_ENST00000348990.5_Missense_Mutation_p.S548F|APP_ENST00000357903.3_Missense_Mutation_p.S604F|APP_ENST00000346798.3_Missense_Mutation_p.S623F|APP_ENST00000359726.3_Missense_Mutation_p.S567F|APP_ENST00000448388.2_Missense_Mutation_p.S513F|APP_ENST00000440126.3_Missense_Mutation_p.S599F|APP_ENST00000439274.2_Missense_Mutation_p.S567F|APP_ENST00000354192.3_Missense_Mutation_p.S492F	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	623					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				AGCCCCAAAAGAATGCCACGG	0.522000													6	45					0	0	1	0	0
SUPT16H	11198	broad.mit.edu	37	14	21840063	21840063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21840063G>A	ENST00000216297.2	-	3	638	c.300C>T	c.(298-300)gcC>gcT	p.A100A		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	100					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TGATGGCAGGGGCTCCATTAG	0.383000													16	59					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158368777	158368777	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158368777G>A	ENST00000334438.1	-	1	479	c.480C>T	c.(478-480)gcC>gcT	p.A160A		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TGAGGTTGGTGGCCACCAAAG	0.473000													41	94					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38646255	38646255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38646255G>A	ENST00000413689.1	-	11	1676	c.1483C>T	c.(1483-1485)Ccc>Tcc	p.P495S	SCN5A_ENST00000423572.2_Missense_Mutation_p.P495S|SCN5A_ENST00000425664.1_Missense_Mutation_p.P495S|SCN5A_ENST00000455624.2_Missense_Mutation_p.P495S|SCN5A_ENST00000450102.2_Missense_Mutation_p.P495S|SCN5A_ENST00000449557.2_Missense_Mutation_p.P495S|SCN5A_ENST00000414099.2_Missense_Mutation_p.P495S|SCN5A_ENST00000451551.2_Missense_Mutation_p.P495S|SCN5A_ENST00000333535.4_Missense_Mutation_p.P495S|SCN5A_ENST00000443581.1_Missense_Mutation_p.P495S	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	495					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCAGACTTGGGGAGCCTGTCC	0.527000													15	30					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38237609	38237609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38237609C>T	ENST00000379705.3	-	6	2489	c.1632G>A	c.(1630-1632)acG>acA	p.T544T	TRPC4_ENST00000494529.1_5'UTR|TRPC4_ENST00000358477.2_Silent_p.T544T|TRPC4_ENST00000447043.1_Silent_p.T544T|TRPC4_ENST00000379673.2_Silent_p.T544T|TRPC4_ENST00000338947.5_Silent_p.T371T|TRPC4_ENST00000355779.2_Silent_p.T544T|TRPC4_ENST00000379679.1_Silent_p.T371T|TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000379681.3_Silent_p.T544T			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	544					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTAACCCTTTCGTTTCTTCAT	0.348000													23	62					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723492	48723492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48723492G>A	ENST00000335017.1	+	1	730	c.418G>A	c.(418-420)Ggc>Agc	p.G140S		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	140	Arg-rich.				chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						GCAAGAGGAGGGCACGCGCGC	0.726000													5	16					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30724604	30724604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30724604C>T	ENST00000262518.4	+	15	2591	c.2206C>T	c.(2206-2208)Cgt>Tgt	p.R736C	SRCAP_ENST00000395059.2_Missense_Mutation_p.R736C|SRCAP_ENST00000344771.4_Missense_Mutation_p.R736C	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	736	Helicase ATP-binding.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCAGGCCTTCCGTCGCAAGAA	0.522000													25	82					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38954452	38954452	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38954452G>A	ENST00000355481.4	+	22	2879	c.2748G>A	c.(2746-2748)gaG>gaA	p.E916E	RYR1_ENST00000360985.3_Silent_p.E916E|RYR1_ENST00000359596.3_Silent_p.E916E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	916	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CAGAGCCTGAGAGGAACTACA	0.622000													38	95					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21165309	21165309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21165309G>A	ENST00000255882.6	-	9	1103	c.1017C>T	c.(1015-1017)atC>atT	p.I339I	PI4KA_ENST00000572273.1_Silent_p.I281I	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	281					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCTCCTCAACGATCTTCTTCA	0.458000													35	85					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74090859	74090859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74090859C>T	ENST00000443185.2	-	5	3527	c.3210G>A	c.(3208-3210)gcG>gcA	p.A1070A	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	1070					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGTAGAGGGTCGCAAAGTCCT	0.592000													18	67					0	0	1	0	0
ELK4	2005	broad.mit.edu	37	1	205589256	205589256	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205589256G>A	ENST00000357992.4	-	3	1257	c.918C>T	c.(916-918)gtC>gtT	p.V306V	ELK4_ENST00000289703.4_Silent_p.V306V	NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TTTCTAGCAAGACTGAATCCT	0.458000			T	SLC45A3	prostate								48	123					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5853187	5853187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:5853187G>A	ENST00000324989.7	-	5	918	c.830C>T	c.(829-831)tCc>tTc	p.S277F	CRMP1_ENST00000397890.2_Missense_Mutation_p.S163F|CRMP1_ENST00000512574.1_Missense_Mutation_p.S161F|CRMP1_ENST00000511535.1_5'UTR	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	163					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		GACTTGGAAGGAATTGACGCC	0.438000													61	156					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903019	5903019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5903019G>A	ENST00000378961.4	+	4	433	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	77						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						AACTGAAAATGAAAACACAAA	0.458000													29	68					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30632987	30632987	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30632987C>A	ENST00000376442.3	-	6	1181	c.986G>T	c.(985-987)tGg>tTg	p.W329L		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	329					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						CGCCTCCTCCCAGCGCCGCTG	0.617000													6	23					0.0215528	0.0215557	1	1	0
MYH14	79784	broad.mit.edu	37	19	50735323	50735323	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50735323C>T	ENST00000440075.2	+	10	1157	c.1110C>T	c.(1108-1110)atC>atT	p.I370I	MYH14_ENST00000425460.1_Silent_p.I370I|MYH14_ENST00000376970.2_Silent_p.I362I|MYH14_ENST00000598205.1_Silent_p.I370I|MYH14_ENST00000596571.1_Silent_p.I362I|MYH14_ENST00000262269.8_Silent_p.I370I|MYH14_ENST00000601313.1_Silent_p.I370I			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	362	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		ACGAGGAAATCATCTGTGAGT	0.627000													14	28					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76482830	76482830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:76482830C>T	ENST00000307431.8	+	7	1291	c.906C>T	c.(904-906)ctC>ctT	p.L302L	CNTNAP4_ENST00000377504.4_Silent_p.L302L|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Silent_p.L306L|CNTNAP4_ENST00000478060.1_Silent_p.L278L	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	303	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AATTCAATCTCATGAATCTTG	0.388000													9	12					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47274755	47274755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47274755C>T	ENST00000396220.1	-	17	1915	c.1893G>A	c.(1891-1893)caG>caA	p.Q631Q	PREX1_ENST00000371941.3_Silent_p.Q631Q			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	631	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AGTCCTCCTCCTGGGGCAGGA	0.672000											OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	276					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147926752	147926752	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:147926752C>T	ENST00000361727.3	+	20	3778	c.3262C>T	c.(3262-3264)Cga>Tga	p.R1088*	CNTNAP2_ENST00000538075.1_Nonsense_Mutation_p.R147*	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1088	Laminin G-like 4.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.R1088*(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTTACAGATTCGATACAACCT	0.443000										HNSCC(39;0.1)			13	49					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139884519	139884519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139884519C>T	ENST00000297183.6	+	16	3242	c.3118C>T	c.(3118-3120)Cct>Tct	p.P1040S	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P1040S|ANKHD1_ENST00000360839.2_Missense_Mutation_p.P1040S	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCGATGCCTCCTGTGTATCC	0.413000													36	97					0	0	1	0	0
FCN3	8547	broad.mit.edu	37	1	27697464	27697464	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27697464C>T	ENST00000270879.4	-	6	399		c.e6-1		FCN3_ENST00000354982.2_Splice_Site	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3						complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGAAACACCTGGGGGAGGG	0.577000													10	69					0	0	1	0	0
LIF	3976	broad.mit.edu	37	22	30639682	30639682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30639682C>T	ENST00000249075.3	-	3	722	c.567G>A	c.(565-567)ggG>ggA	p.G189G	LIF_ENST00000403987.3_3'UTR	NM_002309.4	NP_002300.1	P15018	LIF_HUMAN	leukemia inhibitory factor	189					immune response|leukemia inhibitory factor signaling pathway|negative regulation of hormone secretion|positive regulation of cell proliferation|positive regulation of macrophage differentiation|positive regulation of MAPKKK cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of metanephric nephron tubule epithelial cell differentiation		cytokine activity|growth factor activity|leukemia inhibitory factor receptor binding			breast(1)|lung(3)|skin(3)	7			Epithelial(10;0.171)			GCTTATACTTCCCCAGGAGTT	0.567000													47	105					0	0	1	0	0
OR51B2	79345	broad.mit.edu	37	11	5344754	5344754	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5344754G>A	ENST00000328813.2	-	1	828	c.774C>T	c.(772-774)ttC>ttT	p.F258F	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCTGTAAATGAATGTCAAAC	0.413000													19	90					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78458811	78458811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:78458811C>T	ENST00000566780.1	+	7	1016	c.650C>T	c.(649-651)cCc>cTc	p.P217L	WWOX_ENST00000408984.3_Missense_Mutation_p.P217L|WWOX_ENST00000402655.2_Intron|WWOX_ENST00000406884.2_Intron|WWOX_ENST00000539474.2_Intron	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	217	Interaction with MAPT (By similarity).|Mediates targeting to the mitochondria (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TTTGCTCTACCCTGGAGTCTC	0.468000													130	288					0	0	1	0	0
GBP6	163351	broad.mit.edu	37	1	89847259	89847259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89847259G>A	ENST00000370456.4	+	7	971	c.878G>A	c.(877-879)gGa>gAa	p.G293E	GBP6_ENST00000535065.1_Missense_Mutation_p.G163E	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	293							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		TTAGGTCTGGGAACTCTGGCA	0.483000													35	97					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22205510	22205510	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22205510G>A	ENST00000374695.3	-	18	2527	c.2448C>T	c.(2446-2448)tgC>tgT	p.C816C		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	816	Laminin EGF-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGATGTATGGGCAAGGGCAGG	0.647000													19	27					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47649221	47649221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47649221C>T	ENST00000398742.2	+	5	771	c.722C>T	c.(721-723)tCt>tTt	p.S241F	GPR111_ENST00000507065.1_Missense_Mutation_p.S241F|GPR111_ENST00000296862.1_Missense_Mutation_p.S309F			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	309					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TTCACTTTTTCTATGAGAATT	0.393000													9	155					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27938585	27938585	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:27938585G>A	ENST00000299340.4	-	2	519	c.176_splice	c.e2+1	p.S59_splice	CYYR1_ENST00000400043.3_Splice_Site_p.S59_splice|AP001597.1_ENST00000357401.3_RNA|CYYR1_ENST00000435845.2_Splice_Site_p.S167_splice	NM_052954.2	NP_443186.1	Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	59						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						GAATACTCACGAGAGGATATT	0.433000													10	32					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161747	57161747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57161747G>A	ENST00000371244.4	+	6	769	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	235	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TTATATCCCAGAATATCTCAA	0.418000													115	264					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385791	33385791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33385791C>T	ENST00000537089.1	-	6	641	c.323G>A	c.(322-324)gGa>gAa	p.G108E	AQP7_ENST00000541274.1_Silent_p.R68R|AQP7_ENST00000377425.4_Missense_Mutation_p.G143E|AQP7_ENST00000539936.1_Missense_Mutation_p.G200E			O14520	AQP7_HUMAN	aquaporin 7	200					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CGCCTCTGTTCCTGGCAGTGC	0.617000													13	74					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241710444	241710444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241710444G>A	ENST00000498729.2	-	15	1531	c.1285C>T	c.(1285-1287)Ctc>Ttc	p.L429F	KIF1A_ENST00000320389.7_Missense_Mutation_p.L420F	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	420					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CGCTCGTGGAGGCTGGACACG	0.642000													30	54					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30653799	30653799	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30653799G>A	ENST00000358107.4	-	2	382	c.383C>T	c.(382-384)tCc>tTc	p.S128F	MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	0					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						CACCTGAAGGGAGGGGTGCTC	0.647000													3	13					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220466101	220466101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220466101C>T	ENST00000456909.1	+	3	296	c.206C>T	c.(205-207)tCc>tTc	p.S69F	STK11IP_ENST00000295641.10_Missense_Mutation_p.S80F|STK11IP_ENST00000459692.1_3'UTR			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	80					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGCCGACTCCCCTGTTATT	0.567000													16	50					0	0	1	0	0
MTRF1	9617	broad.mit.edu	37	13	41826864	41826864	+	Missense_Mutation	SNP	C	C	T	rs146179881		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:41826864C>T	ENST00000379480.4	-	5	714	c.614G>A	c.(613-615)cGa>cAa	p.R205Q	MTRF1_ENST00000430347.2_Missense_Mutation_p.R218Q|MTRF1_ENST00000379477.1_Missense_Mutation_p.R205Q|MTRF1_ENST00000239852.6_5'UTR	NM_004294.2	NP_004285.2	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	205					regulation of translational termination	mitochondrion	translation release factor activity, codon specific	p.R205Q(1)		breast(1)|endometrium(4)|large_intestine(3)|lung(6)	14		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		AAATATTTCTCGGGTAAATTG	0.353000													14	46					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853634	42853634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:42853634C>T	ENST00000455697.1	-	8	2758	c.2473G>A	c.(2473-2475)Ggc>Agc	p.G825S	RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.G825S|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.G825S|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.G825S|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.G825S	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	825					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CAATTTTTGCCCTTGTGTCCC	0.403000													49	192					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139192924	139192924	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139192924G>A	ENST00000274710.3	+	3	607	c.402G>A	c.(400-402)cgG>cgA	p.R134R		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	134					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATGTGCGGGATGGCTTCA	0.617000													27	99					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26517322	26517322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26517322G>A	ENST00000456354.2	+	1	271	c.204G>A	c.(202-204)acG>acA	p.T68T		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	68					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAAATCACGAACAAAGCGG	0.602000													9	6					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197183905	197183905	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197183905G>A	ENST00000260983.2	-	9	1891	c.1709C>T	c.(1708-1710)tCt>tTt	p.S570F	HECW2_ENST00000409111.1_Missense_Mutation_p.S214F	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	570					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TACCTCTTGAGAGCCACACAG	0.607000													17	62					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19339336	19339336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19339336C>T	ENST00000252575.5	+	8	2950	c.2907C>T	c.(2905-2907)ttC>ttT	p.F969F	NCAN_ENST00000538881.1_Silent_p.F420F	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	969					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			TAGAGGACTTCGAACTGGAGG	0.642000													49	120					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185018440	185018440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:185018440C>T	ENST00000296741.2	-	7	1216	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	359					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		TCCATGAGCTCGTTGTCGTAG	0.567000													30	62					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854424	40854424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:40854424C>T	ENST00000254691.5	+	3	3189	c.2990C>T	c.(2989-2991)cCc>cTc	p.P997L	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	997	Pro-rich.				apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						CCAAGCCAGCCCTGGCCTCCC	0.527000													125	343					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179414114	179414114	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179414114G>A	ENST00000367618.3	+	16	1960	c.1573G>A	c.(1573-1575)Gag>Aag	p.E525K	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_Missense_Mutation_p.E525K	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	525										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GATCCTGAATGAGAAAAAAGA	0.383000													27	81					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635294	33635294	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33635294G>A	ENST00000380099.3	+	4	2086	c.2078G>A	c.(2077-2079)aGg>aAg	p.R693K	KL_ENST00000426690.2_3'UTR|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	693	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CCGTATACAAGGAATATGACA	0.493000													6	60					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32289578	32289578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32289578C>T	ENST00000400246.1	+	39	4186	c.4044C>T	c.(4042-4044)gtC>gtT	p.V1348V	DEPDC5_ENST00000535622.1_Silent_p.V1248V|DEPDC5_ENST00000382111.2_Silent_p.V1348V|DEPDC5_ENST00000400248.1_Silent_p.V1317V|DEPDC5_ENST00000400249.2_Silent_p.V1317V|DEPDC5_ENST00000266091.3_Silent_p.V1326V|DEPDC5_ENST00000382105.2_3'UTR|DEPDC5_ENST00000382112.3_Silent_p.V1339V|DEPDC5_ENST00000539165.1_Silent_p.V165V			O75140	DEPD5_HUMAN	DEP domain containing 5	1317					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CTGCCACTGTCCCAGAGCAGA	0.493000													26	55					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112525033	112525033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112525033G>A	ENST00000369697.1	-	1	385	c.316C>T	c.(316-318)Ccg>Tcg	p.P106S	KCND3_ENST00000315987.2_Missense_Mutation_p.P106S|KCND3_ENST00000302127.4_Missense_Mutation_p.P106S			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	106						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TCGTAGCGCGGGTAGTGCAGC	0.602000													31	63					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71850684	71850684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71850684C>T	ENST00000445078.2	+	5	738	c.667C>T	c.(667-669)Ccc>Tcc	p.P223S	FOLR3_ENST00000442948.2_Missense_Mutation_p.P182S|FOLR3_ENST00000456237.1_Missense_Mutation_p.P225S			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	181					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	GTCCTACTTCCCCACTCCAGC	0.592000													18	83					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8196821	8196821	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:8196821C>T	ENST00000402384.3	-	8	995	c.729G>A	c.(727-729)gaG>gaA	p.E243E	ICA1_ENST00000406470.2_Silent_p.E243E|ICA1_ENST00000265577.7_Silent_p.E242E|ICA1_ENST00000396675.3_Silent_p.E243E|ICA1_ENST00000407906.1_Silent_p.E243E|ICA1_ENST00000422063.2_Silent_p.E243E|ICA1_ENST00000401396.1_Silent_p.E231E			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	243	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		GAGAAGTTTTCTCCCAAAAAT	0.418000													29	65					0	0	1	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45671756	45671756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:45671756G>A	ENST00000359600.5	-	1	472	c.267C>T	c.(265-267)atC>atT	p.I89I	ZSWIM5_ENST00000464588.1_Intron	NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	89							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					CGGGCTCCGGGATCCGCTCGA	0.677000													12	27					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187209716	187209716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187209716C>T	ENST00000264692.4	+	15	2003	c.1670C>T	c.(1669-1671)aCc>aTc	p.T557I	RP11-215A19.1_ENST00000505103.1_RNA|F11_ENST00000403665.2_Missense_Mutation_p.T609I			P03951	FA11_HUMAN	coagulation factor XI	609	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GGTGTTTACACCAACGTGGTC	0.567000													11	72					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111772339	111772339	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111772339G>A	ENST00000261726.6	+	19	3175	c.3021G>A	c.(3019-3021)gaG>gaA	p.E1007E		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1007						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E1007D(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TGTCCCTGGAGAGCAGCAAGG	0.652000													16	41					0	0	1	0	0
CHTF18	63922	broad.mit.edu	37	16	839621	839621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:839621C>T	ENST00000317063.6	+	5	1103	c.1103C>T	c.(1102-1104)cCc>cTc	p.P368L	CHTF18_ENST00000455171.2_Missense_Mutation_p.P199L|CHTF18_ENST00000262315.9_Missense_Mutation_p.P171L|CHTF18_ENST00000491530.1_3'UTR			Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	171					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				CTGAGGCGGCCCCCCATCTTG	0.677000													22	54					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068338	5068338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5068338C>T	ENST00000380370.1	+	1	583	c.583C>T	c.(583-585)Cgt>Tgt	p.R195C		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGAAACATTCGTATCAATGG	0.438000													40	113					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058581	9058581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9058581G>A	ENST00000397910.4	-	3	29068	c.28865C>T	c.(28864-28866)cCc>cTc	p.P9622L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9624	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGCTAGAGGGCATAACTTC	0.522000													20	53					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42379884	42379884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42379884G>A	ENST00000290472.3	-	2	154	c.60C>T	c.(58-60)acC>acT	p.T20T		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	20	C2.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		GCTGCCAGCAGGTAGAGGCCT	0.637000													12	40					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541273	55541273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55541273G>A	ENST00000361760.1	+	1	360	c.360G>A	c.(358-360)atG>atA	p.M120I		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TAGCAGCGATGGCTTATGACC	0.433000													69	192					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61468560	61468560	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61468560C>T	ENST00000343916.3	+	30	1732	c.1729C>T	c.(1729-1731)Cga>Tga	p.R577*	COL9A3_ENST00000462700.1_3'UTR	NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	577	Triple-helical region 2 (COL2).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					CCCTGGCGCTCGAGGACCCCC	0.672000													44	90					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86487924	86487924	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86487924G>A	ENST00000370571.2	-	18	2621	c.2256_splice	c.e18+1	p.S752_splice	COL24A1_ENST00000436319.1_Splice_Site_p.S752_splice	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	752	Collagen-like 4.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CAAACCTACTGAAGGCCCTGA	0.433000													25	56					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54914527	54914527	+	Missense_Mutation	SNP	C	C	T	rs141439711	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54914527C>T	ENST00000545554.1	+	30	6109	c.6109C>T	c.(6109-6111)Cgt>Tgt	p.R2037C	UNC13C_ENST00000537900.1_Missense_Mutation_p.R2035C|UNC13C_ENST00000539562.2_5'UTR|UNC13C_ENST00000260323.11_Missense_Mutation_p.R2037C			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2037					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATTTTCAGGTCGTTCCTCCAA	0.398000													28	61					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6924073	6924073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6924073G>A	ENST00000011653.4	+	5	780	c.522G>A	c.(520-522)ctG>ctA	p.L174L	CD4_ENST00000538827.1_3'UTR|CD4_ENST00000541982.1_Silent_p.L119L	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	174	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				TGTCTCAGCTGGAGCTCCAGG	0.547000													21	50					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180579	124180579	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124180579G>A	ENST00000357821.2	-	1	154	c.84C>T	c.(82-84)ttC>ttT	p.F28F		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GGAACAGGAGGAAGAGGGGCA	0.473000													30	125					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54759173	54759173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54759173C>T	ENST00000450632.1	-	5	978	c.901G>A	c.(901-903)Gac>Aac	p.D301N	LILRB5_ENST00000449561.2_Missense_Mutation_p.D310N|LILRB5_ENST00000345866.6_Missense_Mutation_p.D210N|LILRB5_ENST00000316219.5_Missense_Mutation_p.D310N			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	310	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCCAGGGGGTCGCTGGGGGCC	0.667000													22	42					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587930	55587930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55587930C>T	ENST00000333976.4	+	1	845	c.825C>T	c.(823-825)gcC>gcT	p.A275A		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TCAAAGTGGCCTCTGTGTTTT	0.498000													15	105					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42815746	42815746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42815746C>T	ENST00000398600.2	+	13	1986	c.961C>T	c.(961-963)Ccc>Tcc	p.P321S	MX1_ENST00000455164.2_Missense_Mutation_p.P321S|MX1_ENST00000398598.3_Missense_Mutation_p.P321S|MX1_ENST00000288383.6_Missense_Mutation_p.P298S	NM_001144925.1	NP_001138397.1	P20591	MX1_HUMAN	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	321					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GGCCACGGTTCCCTGCCTGGC	0.507000													40	135					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143993426	143993426	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143993426G>A	ENST00000323110.2	-	9	1484	c.1482C>T	c.(1480-1482)tcC>tcT	p.S494S		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	494					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TGAGGAGGGGGGACGTGCCAG	0.567000									Familial Hyperaldosteronism type I				24	57					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034580	52034580	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52034580C>T	ENST00000346477.3	-	2	329	c.261G>A	c.(259-261)gaG>gaA	p.E87E	SIGLEC6_ENST00000359982.4_Silent_p.E87E|SIGLEC6_ENST00000391797.3_Silent_p.E87E|SIGLEC6_ENST00000343300.4_Silent_p.E87E|SIGLEC6_ENST00000436458.1_Silent_p.E51E|SIGLEC6_ENST00000425629.3_Silent_p.E87E	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	87	Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CCCGGGTCTCCTCCTGCACTT	0.572000													36	100					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39504152	39504152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:39504152G>A	ENST00000518318.2	+	10	1877	c.1835G>A	c.(1834-1836)cGa>cAa	p.R612Q	POU6F2_ENST00000559001.1_Missense_Mutation_p.R593Q|POU6F2_ENST00000403058.1_Missense_Mutation_p.R648Q			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	648					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						AACTATGACCGAGAAGTAGTT	0.498000													4	21					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48753410	48753410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48753410C>T	ENST00000285238.8	+	22	3106	c.3026C>T	c.(3025-3027)tCc>tTc	p.S1009F	ABCC3_ENST00000510891.1_3'UTR	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1009	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AACAACACTTCCCTGAGGCTG	0.547000													21	34					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46806723	46806723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46806723C>T	ENST00000230588.4	+	14	2100	c.2091C>T	c.(2089-2091)atC>atT	p.I697I		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	697	EGF-like.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			TCAGGTGCATCTCTGGACATG	0.572000													58	139					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20150060	20150060	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20150060C>T	ENST00000245957.5	+	13	1417	c.1341C>T	c.(1339-1341)acC>acT	p.T447T	C20orf26_ENST00000451767.2_Silent_p.T447T|C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377306.1_Silent_p.T447T|C20orf26_ENST00000377309.2_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	447										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ACACCTGCACCCTCGAGCAGG	0.488000													27	81					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626504	49626504	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49626504G>A	ENST00000371571.4	-	2	657	c.372C>T	c.(370-372)ttC>ttT	p.F124F	KCNG1_ENST00000396017.3_Silent_p.F124F|RP5-955M13.4_ENST00000424566.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	124						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GGATAGTGCCGAAGGCCCCCG	0.632000													13	66					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133667776	133667776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133667776C>T	ENST00000310926.4	-	7	1174	c.901G>A	c.(901-903)Gag>Aag	p.E301K	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.E225K	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	301					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GACTTGGCCTCCTCCAACTTC	0.587000													32	78					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157803081	157803081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157803081G>A	ENST00000368174.4	-	5	1036	c.940C>T	c.(940-942)Cgt>Tgt	p.R314C		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	314	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCTGAGCAACGAACATTATCC	0.582000													38	78					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7510075	7510075	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7510075G>A	ENST00000313599.3	-	19	4344	c.4287C>T	c.(4285-4287)acC>acT	p.T1429T	CD163L1_ENST00000416109.2_Silent_p.T1439T|CD163L1_ENST00000396630.1_Silent_p.T1397T			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1429						extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CATGGTTGGGGGTGTCATCTG	0.463000													4	50					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017344	93017344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:93017344C>T	ENST00000521553.1	-	4	651	c.629G>A	c.(628-630)aGg>aAg	p.R210K	RUNX1T1_ENST00000436581.2_Splice_Site_p.R258_splice|RUNX1T1_ENST00000360348.2_Splice_Site_p.R210_splice|RUNX1T1_ENST00000523629.1_Splice_Site_p.R247_splice|RUNX1T1_ENST00000396218.1_Splice_Site_p.R220_splice|RUNX1T1_ENST00000520724.1_Splice_Site_p.R210_splice|RUNX1T1_ENST00000265814.3_Splice_Site_p.R247_splice|RUNX1T1_ENST00000422361.2_Splice_Site_p.R210_splice|RUNX1T1_ENST00000518844.1_Splice_Site_p.R220_splice			Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	247	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCCCTCTCACCTGTCTGGAGT	0.512000													21	100					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10885926	10885926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10885926G>A	ENST00000254488.2	+	5	717	c.651G>A	c.(649-651)ggG>ggA	p.G217G		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	217					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCTCTGACGGGATCGAGCACA	0.587000													19	41					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50169713	50169713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50169713G>A	ENST00000216267.8	-	10	3309	c.2823C>T	c.(2821-2823)ccC>ccT	p.P941P	BRD1_ENST00000404034.1_Silent_p.P941P|BRD1_ENST00000404760.1_Silent_p.P1072P|BRD1_ENST00000542442.1_Silent_p.P629P|BRD1_ENST00000457780.2_3'UTR|BRD1_ENST00000342989.5_Silent_p.P667P	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	941	PWWP.				histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CCGGGTAGGAGGGGTAGCCGC	0.692000													21	34					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50660972	50660972	+	Missense_Mutation	SNP	G	G	A	rs144692967	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50660972G>A	ENST00000439308.2	-	14	2812	c.2320C>T	c.(2320-2322)Cgg>Tgg	p.R774W	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Missense_Mutation_p.R774W	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	774					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TTCTGCTCCCGACGAGCTGCC	0.567000													23	49					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559002	140559002	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140559002G>A	ENST00000239444.2	+	1	1632	c.1387G>A	c.(1387-1389)Gag>Aag	p.E463K		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		463	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGTCCGCGAGAACAACAG	0.627000													85	323					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89385059	89385059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89385059G>A	ENST00000439576.2	+	5	1092	c.718G>A	c.(718-720)Gag>Aag	p.E240K	ACAN_ENST00000558207.1_Missense_Mutation_p.E240K|ACAN_ENST00000559004.1_Missense_Mutation_p.E240K|ACAN_ENST00000561243.1_Missense_Mutation_p.E240K|ACAN_ENST00000352105.7_Missense_Mutation_p.E240K	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	240					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGACACCAACGAGACCTATGA	0.607000													31	109					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874255	74874255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74874255G>A	ENST00000331628.3	-	4	947	c.700C>T	c.(700-702)Cag>Tag	p.Q234*	SYNDIG1L_ENST00000554823.1_Nonsense_Mutation_p.Q234*	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	234					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						TGACCGTTCTGGGACATGTAA	0.642000													30	77					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669833	158669833	+	Missense_Mutation	SNP	G	G	A	rs150220329		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158669833G>A	ENST00000359610.2	-	1	653	c.610C>T	c.(610-612)Cat>Tat	p.H204Y		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					TCCACTGCATGAATGACATCC	0.488000													34	95					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82644788	82644788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:82644788G>A	ENST00000533655.1	+	6	2620	c.2408G>A	c.(2407-2409)gGt>gAt	p.G803D	C11orf82_ENST00000329143.3_Missense_Mutation_p.G502D|C11orf82_ENST00000430323.2_Missense_Mutation_p.G803D|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	803					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						GATCTTGATGGTAACTATGAA	0.368000													18	39					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54849677	54849677	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54849677C>T	ENST00000291759.4	-	3	401	c.345G>A	c.(343-345)ctG>ctA	p.L115L		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	115	Ig-like C2-type 1.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CTGTCACCACCAGCTCCAGGG	0.622000													16	67					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36129141	36129141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36129141C>T	ENST00000540320.1	+	44	7358	c.6824C>T	c.(6823-6825)aCt>aTt	p.T2275I	NBEA_ENST00000379939.2_Missense_Mutation_p.T2272I|NBEA_ENST00000310336.4_Missense_Mutation_p.T2275I|NBEA_ENST00000537702.1_Missense_Mutation_p.T68I|NBEA_ENST00000400445.3_Missense_Mutation_p.T2275I			Q8NFP9	NBEA_HUMAN	neurobeachin	2275	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TCATTGGCCACTCCTCGACAG	0.328000													11	21					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106899194	106899194	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106899194C>T	ENST00000369701.3	+	8	1479	c.1252C>T	c.(1252-1254)Cga>Tga	p.R418*		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	418						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CGTGTCTTATCGAAGAGAGGC	0.502000													48	106					0	0	1	0	0
FAM169A	26049	broad.mit.edu	37	5	74100324	74100324	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:74100324C>T	ENST00000389156.4	-	8	996	c.906G>A	c.(904-906)caG>caA	p.Q302Q	FAM169A_ENST00000380515.3_3'UTR|FAM169A_ENST00000510496.1_Silent_p.Q242Q	NM_015566.2	NP_056381.1	Q9Y6X4	F169A_HUMAN	family with sequence similarity 169, member A	302										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	27						CTACAGTTAGCTGCATCTCAC	0.323000													28	79					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215866333	215866333	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215866333C>T	ENST00000272895.7	-	21	3031	c.2812G>A	c.(2812-2814)Gaa>Aaa	p.E938K	ABCA12_ENST00000389661.4_Missense_Mutation_p.E620K	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	938					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity	p.E938K(1)		NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTCTCCATTTCATCTATGGTT	0.388000													58	159					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61034973	61034973	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61034973G>A	ENST00000335613.5	-	16	2312	c.1926C>T	c.(1924-1926)ttC>ttT	p.F642F	VWCE_ENST00000535710.1_Silent_p.F107F	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	642	VWFC 5.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GCACAGACGGGAAGGTCTCGT	0.597000													21	76					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39885739	39885739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39885739C>T	ENST00000260356.5	+	19	3302	c.3137C>T	c.(3136-3138)tCc>tTc	p.S1046F		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	1046	TSP C-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GTCACCCAGTCCTACTGGGAC	0.547000													50	129					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348996	30348996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:30348996C>T	ENST00000327564.7	+	1	973	c.912C>T	c.(910-912)tcC>tcT	p.S304S	LRRC37B_ENST00000341671.7_Silent_p.S277S|LRRC37B_ENST00000543378.2_Silent_p.S195S|LRRC37B_ENST00000394713.3_Silent_p.S277S|LRRC37B_ENST00000584368.1_Silent_p.S289S			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	277						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				ACATCCAGTCCTCTTCACTCC	0.552000													91	85					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33342596	33342596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33342596G>A	ENST00000374796.2	-	9	4174	c.1604C>T	c.(1603-1605)tCg>tTg	p.S535L	NCOA6_ENST00000359003.2_Missense_Mutation_p.S535L			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	535	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						TGCTGTGGTCGAAGGCACCTG	0.498000													10	85					0	0	1	0	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044161	90044161	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90044161C>T	ENST00000462693.1	+	0	112																											GACCCAGACTCCACTCTCCTC	0.448000													40	103					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984557	85984557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85984557G>A	ENST00000372113.4	-	2	429	c.424C>T	c.(424-426)Ctc>Ttc	p.L142F	LRIT2_ENST00000538192.1_Missense_Mutation_p.L142F	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	142						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						AGCTCAGGGAGTGCATCAATC	0.527000													22	123					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40037088	40037088	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40037088G>A	ENST00000336649.4	+	8	957	c.957G>A	c.(955-957)tgG>tgA	p.W319*	CACNA1I_ENST00000404898.1_Nonsense_Mutation_p.W319*|CACNA1I_ENST00000402142.3_Nonsense_Mutation_p.W319*|CACNA1I_ENST00000401624.1_Nonsense_Mutation_p.W319*|CACNA1I_ENST00000400164.3_Nonsense_Mutation_p.W319*|CACNA1I_ENST00000407673.1_Nonsense_Mutation_p.W319*			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	319					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GTGTCAACTGGAACCGTTACT	0.587000													21	64					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158641160	158641160	+	Silent	SNP	G	G	A	rs41273525		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158641160G>A	ENST00000368148.3	-	12	1752	c.1572C>T	c.(1570-1572)gcC>gcT	p.A524A	SPTA1_ENST00000368147.3_Silent_p.A524A	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	524					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGGCAGTAAAGGCTTCCTCAA	0.468000													9	43					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444075	5444075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5444075C>T	ENST00000300778.4	+	1	735	c.645C>T	c.(643-645)ctC>ctT	p.L215L	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCCTCTGCTCATTGTGATCT	0.493000													46	151					0	0	1	0	0
FBXO9	26268	broad.mit.edu	37	6	52962573	52962573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52962573C>T	ENST00000244426.6	+	12	1461	c.1289C>T	c.(1288-1290)cCc>cTc	p.P430L	FBXO9_ENST00000323557.7_Missense_Mutation_p.P420L|FBXO9_ENST00000370939.3_Missense_Mutation_p.P386L	NM_012347.4	NP_036479.1	Q9UK97	FBX9_HUMAN	F-box protein 9	430						ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)|large_intestine(4)|lung(1)|pancreas(2)|skin(1)	9	Lung NSC(77;0.103)					ATGTACACCCCCTTGTTCTTC	0.403000													7	26					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13794146	13794146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13794146C>T	ENST00000265104.4	-	48	8013	c.7909G>A	c.(7909-7911)Gat>Aat	p.D2637N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2637	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATTCGTTTATCCACATAGCTC	0.358000									Kartagener syndrome				16	52					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102045066	102045066	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102045066A>C	ENST00000549145.1	+	15	1485	c.1385A>C	c.(1384-1386)gAa>gCa	p.E462A	MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000361466.2_Missense_Mutation_p.E474A|MYBPC1_ENST00000360610.2_Missense_Mutation_p.E449A|MYBPC1_ENST00000550270.1_Missense_Mutation_p.E449A|MYBPC1_ENST00000547509.1_Missense_Mutation_p.E435A|MYBPC1_ENST00000547405.1_Missense_Mutation_p.E423A|RP11-755O11.2_ENST00000547027.1_RNA|MYBPC1_ENST00000545503.2_Missense_Mutation_p.E449A|MYBPC1_ENST00000541119.1_Missense_Mutation_p.E437A|MYBPC1_ENST00000536007.1_Missense_Mutation_p.E430A|MYBPC1_ENST00000452455.2_Missense_Mutation_p.E449A|MYBPC1_ENST00000392934.3_Missense_Mutation_p.E436A|MYBPC1_ENST00000361685.2_Missense_Mutation_p.E474A|MYBPC1_ENST00000441232.1_Missense_Mutation_p.E449A|MYBPC1_ENST00000551300.1_Missense_Mutation_p.E350A|MYBPC1_ENST00000553190.1_Missense_Mutation_p.E449A			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	449	Ig-like C2-type 4.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						CTTGGAAAAGAAATCTGCCTG	0.418000													36	121					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184792440	184792440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:184792440C>T	ENST00000367511.3	-	8	1039	c.846G>A	c.(844-846)ctG>ctA	p.L282L	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	282					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GATGCTGAACCAGGGTGTAGG	0.507000													19	51					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138738921	138738921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:138738921G>A	ENST00000329447.5	-	1	847	c.583C>T	c.(583-585)Cca>Tca	p.P195S	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	195	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAGGGTTCTGGGATGGGGCCC	0.632000													16	49					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2967436	2967436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:2967436G>A	ENST00000397461.1	+	12	1715	c.1331G>A	c.(1330-1332)gGa>gAa	p.G444E	CNTN4_ENST00000418658.1_Missense_Mutation_p.G444E|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000448906.2_Missense_Mutation_p.G116E|CNTN4_ENST00000358480.3_Missense_Mutation_p.G225E|CNTN4_ENST00000397459.2_Missense_Mutation_p.G116E|CNTN4_ENST00000427331.1_Missense_Mutation_p.G444E	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	444	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TGGAAGAAAGGAAGGGATATA	0.338000													27	114					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50662634	50662634	+	Missense_Mutation	SNP	G	G	A	rs139968102		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50662634G>A	ENST00000439308.2	-	13	2698	c.2206C>T	c.(2206-2208)Cgt>Tgt	p.R736C	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Missense_Mutation_p.R736C	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	736					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CGGAGTTCACGGGCGTAGCTG	0.617000													14	51					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52575039	52575039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52575039C>T	ENST00000591504.1	-	11	1202	c.928G>A	c.(928-930)Gta>Ata	p.V310I	CCDC68_ENST00000432185.1_Missense_Mutation_p.V310I|CCDC68_ENST00000337363.4_Missense_Mutation_p.V310I	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	310										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		GCCTTAGATACCTTTGTCCTA	0.378000													10	107					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47560241	47560241	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47560241G>A	ENST00000273859.3	+	12	2654	c.2385G>A	c.(2383-2385)acG>acA	p.T795T	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	795					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						TGGTGTATACGAAAGGCGCTG	0.418000													41	107					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113166771	113166771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113166771G>A	ENST00000401783.2	-	39	9838	c.9502C>T	c.(9502-9504)Cgc>Tgc	p.R3168C	SVEP1_ENST00000374469.1_Missense_Mutation_p.R3145C|SVEP1_ENST00000297826.5_Missense_Mutation_p.R1094C	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3168	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GGGAACCAGCGACCATCTTTC	0.413000													111	203					0	0	1	0	0
NCR1	9437	broad.mit.edu	37	19	55417934	55417934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55417934G>A	ENST00000594765.1	+	3	149	c.124G>A	c.(124-126)Gaa>Aaa	p.E42K	NCR1_ENST00000338835.5_Missense_Mutation_p.E42K|NCR1_ENST00000598576.1_Missense_Mutation_p.E30K|NCR1_ENST00000447255.1_Missense_Mutation_p.E42K|NCR1_ENST00000350790.5_Intron|NCR1_ENST00000291890.4_Missense_Mutation_p.E42K|NCR1_ENST00000357397.5_Intron			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	42	Ig-like 1.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		GGTTCCAAAGGAAAAGCAAGT	0.547000													44	91					0	0	1	0	0
FGF9	2254	broad.mit.edu	37	13	22275367	22275367	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:22275367C>T	ENST00000382353.5	+	3	950	c.420C>T	c.(418-420)ttC>ttT	p.F140F	FGF9_ENST00000478546.1_3'UTR	NM_002010.2	NP_002001.1	P31371	FGF9_HUMAN	fibroblast growth factor 9	140					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|male gonad development|positive regulation of cell division	extracellular space	growth factor activity|heparin binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|skin(2)	9		all_cancers(29;1.23e-20)|all_epithelial(30;9.83e-19)|all_lung(29;9.64e-17)|Lung SC(185;0.0262)|Breast(139;0.106)		all cancers(112;3.92e-05)|Epithelial(112;0.000166)|OV - Ovarian serous cystadenocarcinoma(117;0.00314)|Lung(94;0.163)		GAGAACAGTTCGAAGAAAACT	0.393000													17	41					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2172905	2172905	+	Missense_Mutation	SNP	G	G	A	rs140423155		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:2172905G>A	ENST00000511885.2	-	12	1731	c.1378C>T	c.(1378-1380)Cgt>Tgt	p.R460C	POLN_ENST00000515357.1_5'UTR|POLN_ENST00000382865.1_Missense_Mutation_p.R460C			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	460					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TCCTTGAGACGAGCCTGAAAA	0.363000								DNA polymerases (catalytic subunits)					29	62					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848305	215848305	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215848305G>A	ENST00000366943.2	-	63	13334	c.12948C>T	c.(12946-12948)ttC>ttT	p.F4316F	USH2A_ENST00000307340.3_Silent_p.F4316F			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4316	Fibronectin type-III 28.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAGTGTAATTGAAAGTCACAG	0.448000										HNSCC(13;0.011)			59	125					0	0	1	0	0
FCN1	2219	broad.mit.edu	37	9	137809704	137809704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137809704C>T	ENST00000371806.3	-	1	105	c.14G>A	c.(13-15)gGa>gAa	p.G5E		NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1	5					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CATGGTGGCTCCACTCAGCTC	0.582000													21	62					0	0	1	0	0
TRBV19	28568	broad.mit.edu	37	7	142326973	142326973	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142326973G>A	ENST00000390393.3	+	0	479																											GGAGAAGAAGGAATCCTTTCC	0.488000													32	142					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14960278	14960278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14960278G>A	ENST00000285046.5	+	13	3617	c.3507G>A	c.(3505-3507)atG>atA	p.M1169I	FGD5_ENST00000543601.1_Missense_Mutation_p.M928I|FGD5_ENST00000476851.1_3'UTR	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1169	PH 1.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GCCCTGTGATGGAGAAAGTGC	0.597000													20	54					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67912442	67912442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67912442C>T	ENST00000358933.5	+	10	1331	c.1092C>T	c.(1090-1092)gtC>gtT	p.V364V	EDC4_ENST00000574770.1_3'UTR	NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	364					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTTGCAGTGTCCCTTTCTGGA	0.567000													34	83					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2426252	2426252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2426252C>T	ENST00000452833.1	-	24	3427	c.3419G>A	c.(3418-3420)gGa>gAa	p.G1140E	TRPM5_ENST00000528453.1_Missense_Mutation_p.G1139E|AC124057.5_ENST00000433035.1_RNA|TRPM5_ENST00000155858.6_Missense_Mutation_p.G1138E|TRPM5_ENST00000533060.1_Missense_Mutation_p.G1146E			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	1138						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CAGCTGGCTTCCCTCGCCACA	0.662000													17	26					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30257204	30257204	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30257204G>A	ENST00000359358.4	-	8	2116	c.1678C>T	c.(1678-1680)Cga>Tga	p.R560*		NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	560						cytosol|endoplasmic reticulum membrane		p.R560*(1)		breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GGGCCACTTCGACCCTCCAAA	0.478000													30	85					0	0	1	0	0
HEATR6	63897	broad.mit.edu	37	17	58148147	58148147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58148147C>T	ENST00000184956.6	-	6	737	c.721G>A	c.(721-723)Ggt>Agt	p.G241S	HEATR6_ENST00000585976.1_Missense_Mutation_p.G241S	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	241							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			GACTGTATACCTTTTAATGCA	0.403000													25	65					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55935584	55935584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55935584C>T	ENST00000244728.5	-	21	2375	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.E60K|COL21A1_ENST00000535941.1_Missense_Mutation_p.E660K|COL21A1_ENST00000370819.1_Missense_Mutation_p.E657K	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	660					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ATTCCAGGTTCACCTTTGCTT	0.328000													7	24					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30899683	30899683	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30899683G>C	ENST00000540456.1	-	2	210	c.17C>G	c.(16-18)tCc>tGc	p.S6C	SEC14L4_ENST00000392772.2_5'UTR|SEC14L4_ENST00000381982.3_Missense_Mutation_p.F37L|SEC14L4_ENST00000255858.7_Missense_Mutation_p.F37L			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	0						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	AGCGCAGGAGGAAGTAGTCAT	0.612000													14	42					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437709	120437709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120437709G>A	ENST00000369400.1	-	1	1409	c.1251C>T	c.(1249-1251)tcC>tcT	p.S417S		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	417	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		ACTCCTCTGTGGAACCACAGT	0.438000													50	155					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228247937	228247937	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228247937C>G	ENST00000366753.2	+	5	1137	c.1090C>G	c.(1090-1092)Cag>Gag	p.Q364E	WNT3A_ENST00000284523.1_3'UTR			P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	0					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				TTCAGCCCACCAGCCACCTCA	0.637000													32	77					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55070823	55070823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55070823C>T	ENST00000371316.3	+	13	1393	c.1311C>T	c.(1309-1311)gcC>gcT	p.A437A	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000343744.2_Silent_p.A437A	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	437	START.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						TGGATGCAGCCCAGGCCTTCC	0.617000													19	63					0	0	1	0	0
TMEM117	84216	broad.mit.edu	37	12	44770423	44770423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:44770423C>T	ENST00000266534.3	+	7	941	c.814C>T	c.(814-816)Cct>Tct	p.P272S	TMEM117_ENST00000551577.1_Intron|TMEM117_ENST00000536799.1_Missense_Mutation_p.P168S|TMEM117_ENST00000546978.1_3'UTR	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	272						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TGTAAATCTCCCTGGTTTGCA	0.388000													41	146					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16059904	16059904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16059904C>T	ENST00000322107.1	+	1	87	c.87C>T	c.(85-87)ttC>ttT	p.F29F		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						CCATCTTGTTCCTGCTGTACC	0.483000													96	245					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85382937	85382937	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85382937C>T	ENST00000258888.5	+	5	1200	c.1033C>T	c.(1033-1035)Cga>Tga	p.R345*		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	345	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCTAGGTGTCGAGAAGAAGA	0.632000													25	93					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17550869	17550869	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17550869C>T	ENST00000375471.4	+	4	446	c.354C>T	c.(352-354)tcC>tcT	p.S118S		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	118					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	CAGATATTTCCCTTGAGGTTG	0.592000													11	23					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36036035	36036035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36036035G>A	ENST00000282507.3	-	7	1438	c.1337C>T	c.(1336-1338)tCc>tTc	p.S446F	UGT3A2_ENST00000545528.1_Missense_Mutation_p.S144F|UGT3A2_ENST00000513300.1_Missense_Mutation_p.S412F	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	446						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGCGGGTGGGAGCGCAGGAT	0.587000													10	38					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48800332	48800332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48800332C>T	ENST00000315396.7	-	14	2596	c.1914G>A	c.(1912-1914)tcG>tcA	p.S638S		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	638	Ser-rich.									cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GGCCTCCGCTCGAATCAGACG	0.672000													11	140					0	0	1	0	0
ZNF207	7756	broad.mit.edu	37	17	30688494	30688494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:30688494C>T	ENST00000394670.4	+	6	728	c.559C>T	c.(559-561)Cat>Tat	p.H187Y	ZNF207_ENST00000342555.6_Missense_Mutation_p.H190Y|ZNF207_ENST00000321233.6_Intron|ZNF207_ENST00000341711.6_Missense_Mutation_p.H88Y|ZNF207_ENST00000577908.1_Missense_Mutation_p.H187Y|ZNF207_ENST00000394673.2_Missense_Mutation_p.H187Y	NM_001098507.1	NP_001091977.1	O43670	ZN207_HUMAN	zinc finger protein 207	184						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			CAGATTGCATCATCAGAGAAA	0.313000													20	25					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64589690	64589690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64589690C>T	ENST00000498707.1	-	25	3997	c.3655G>A	c.(3655-3657)Gag>Aag	p.E1219K	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.E1191K	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1219	TSP type-1 7.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAGGCACTCTCGTCAGCCACA	0.542000													6	70					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111564690	111564690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111564690C>T	ENST00000393934.3	+	4	1459	c.889C>T	c.(889-891)Cct>Tct	p.P297S	PHLDB2_ENST00000393923.3_5'UTR|PLCXD2_ENST00000477665.1_3'UTR	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	0					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CCCAGTTTATCCTTTGAGATT	0.468000													34	92					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10524919	10524919	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10524919C>T	ENST00000396560.2	+	3	669	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	ATF7IP2_ENST00000356427.2_Nonsense_Mutation_p.Q148*|ATF7IP2_ENST00000396559.1_Nonsense_Mutation_p.Q148*|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000324570.5_Nonsense_Mutation_p.Q148*	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						TTCTGAGCATCAGACAAATGT	0.448000													23	127					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47675066	47675066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47675066C>T	ENST00000283303.2	+	2	343	c.85C>T	c.(85-87)Cac>Tac	p.H29Y	GPR115_ENST00000327753.3_Missense_Mutation_p.H29Y|GPR115_ENST00000371220.1_Missense_Mutation_p.H86Y	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	29					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						ATCCAAGATTCACCTAAAAGT	0.383000													8	100					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135693067	135693067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135693067C>T	ENST00000513104.1	-	2	291	c.9G>A	c.(7-9)agG>agA	p.R3R	TRPC7_ENST00000355180.3_Silent_p.R3R|TRPC7_ENST00000426057.2_Silent_p.R3R	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	3					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGGTGCTGTTCCTCAACCTAT	0.527000													11	29					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43052675	43052675	+	Missense_Mutation	SNP	G	G	A	rs145902391		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43052675G>A	ENST00000316099.3	+	8	999	c.910G>A	c.(910-912)Gat>Aat	p.D304N	HNF4A_ENST00000443598.2_Missense_Mutation_p.D304N|HNF4A_ENST00000457232.1_Missense_Mutation_p.D282N|HNF4A_ENST00000415691.1_Missense_Mutation_p.D304N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	304					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGGGCTGAGCGATCCAGGGAA	0.607000													9	22					0	0	1	0	0
FMR1NB	158521	broad.mit.edu	37	X	147062951	147062951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:147062951G>A	ENST00000370467.3	+	1	103	c.29G>A	c.(28-30)gGg>gAg	p.G10E		NM_152578.2	NP_689791.1	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	10						integral to membrane				breast(2)|cervix(1)|endometrium(3)|large_intestine(7)|lung(10)|ovary(1)|skin(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGCGAAGGGGAGGAATAGG	0.597000													17	37					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13792151	13792151	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13792151G>A	ENST00000265104.4	-	50	8504	c.8400C>T	c.(8398-8400)gtC>gtT	p.V2800V		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2800	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTCCCTGCCAGACCCGAGAAA	0.403000									Kartagener syndrome				23	41					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414808	105414808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105414808G>A	ENST00000333244.5	-	7	7099	c.6980C>T	c.(6979-6981)tCg>tTg	p.S2327L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2327						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CACCCCAAACGACAGCATCTT	0.602000													33	362					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25326342	25326342	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25326342C>T	ENST00000546682.1	+	0	42				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TGTGGGGGCTCCTCCAGAGGC	0.507000													16	21					0	0	1	0	0
CERS6	253782	broad.mit.edu	37	2	169622102	169622102	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169622102G>A	ENST00000305747.6	+	9	1433	c.845_splice	c.e9-1	p.W282_splice	CERS6_ENST00000392687.4_Splice_Site_p.W282_splice	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	282	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										TTTTCCTTAGGGTGTTAAATA	0.418000													23	76					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68702871	68702871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68702871C>T	ENST00000255078.3	+	12	1848	c.1737C>T	c.(1735-1737)ttC>ttT	p.F579F	IGHMBP2_ENST00000541229.1_3'UTR	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	579					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TACTGTCCTTCGTCAGATCCA	0.537000													9	70					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100154749	100154749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100154749G>A	ENST00000263174.4	+	7	1308	c.933G>A	c.(931-933)gaG>gaA	p.E311E	PALMD_ENST00000605497.1_Silent_p.E311E	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	311					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		GTCTTTCAGAGGAAAGGGGAA	0.443000													15	83					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76790259	76790259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76790259C>T	ENST00000287239.4	+	18	6166	c.5677C>T	c.(5677-5679)Ccg>Tcg	p.P1893S	KAT6B_ENST00000372714.1_Missense_Mutation_p.P1601S|KAT6B_ENST00000372725.1_Missense_Mutation_p.P1601S|KAT6B_ENST00000372724.1_Missense_Mutation_p.P1601S|KAT6B_ENST00000372711.1_Missense_Mutation_p.P1710S	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	1893	Interaction with RUNX1 and RUNX2.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										GAATCTGCCGCCGCCTCTTTT	0.552000													80	199					0	0	1	0	0
PRDM12	59335	broad.mit.edu	37	9	133540058	133540058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133540058C>T	ENST00000253008.2	+	1	78	c.18C>T	c.(16-18)ctC>ctT	p.L6L		NM_021619.2	NP_067632.2	Q9H4Q4	PRD12_HUMAN	PR domain containing 12	6					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GCTCCGTGCTCCCGGCTGAGG	0.746000													8	11					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20955880	20955880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20955880G>A	ENST00000261383.3	-	58	11448	c.11449C>T	c.(11449-11451)Ctg>Ttg	p.L3817L	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3817					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCCTCAAACAGCTGGTTGGTT	0.547000													24	54					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167279836	167279836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167279836C>T	ENST00000409855.1	-	18	3086	c.2960G>A	c.(2959-2961)tGg>tAg	p.W987*		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	987					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						ATATGCCATCCATTTTAGAAG	0.318000													23	51					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	93879776	93879776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:93879776G>A	ENST00000377047.4	+	1	682	c.67G>A	c.(67-69)Gcg>Acg	p.A23T		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	23						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CCCCGCCGGGGCGGATGTGAA	0.627000											OREG0022460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	53					0	0	1	0	0
SOX11	6664	broad.mit.edu	37	2	5832928	5832928	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:5832928A>G	ENST00000322002.3	+	1	130	c.75A>G	c.(73-75)gaA>gaG	p.E25E		NM_003108.3	NP_003099.1	P35716	SOX11_HUMAN	SRY (sex determining region Y)-box 11	25					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(5)|cervix(1)|endometrium(1)|liver(1)|lung(4)|stomach(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		AGGAGGGCGAATTCATGGCTT	0.657000													5	22					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860848	16860848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16860848C>T	ENST00000524140.2	+	6	1813	c.1395C>T	c.(1393-1395)atC>atT	p.I465I	NWD1_ENST00000523826.1_Silent_p.I259I|NWD1_ENST00000379808.3_Silent_p.I465I|NWD1_ENST00000339803.6_Silent_p.I330I|NWD1_ENST00000552788.1_Silent_p.I465I|NWD1_ENST00000549814.1_Silent_p.I465I	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	465	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TGCACCTCATCCTCTCAGCTT	0.642000													8	124					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189612096	189612096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189612096C>T	ENST00000264731.3	+	14	1937	c.1848C>T	c.(1846-1848)ctC>ctT	p.L616L	TP63_ENST00000449992.1_Silent_p.L437L|TP63_ENST00000440651.2_Silent_p.L612L|TP63_ENST00000320472.5_3'UTR|TP63_ENST00000382063.4_Silent_p.L531L|TP63_ENST00000456148.1_Silent_p.L518L|TP63_ENST00000354600.5_Silent_p.L522L	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	616	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CTTCTCATCTCCTGCGGACCC	0.572000										HNSCC(45;0.13)			25	88					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178555048	178555048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178555048G>A	ENST00000251582.7	-	17	2630	c.2529C>T	c.(2527-2529)gtC>gtT	p.V843V		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	843	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TGTTGTCGTCGACATTCAGTG	0.582000													11	112					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70635015	70635015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70635015C>T	ENST00000381269.2	-	2	878	c.125G>A	c.(124-126)gGg>gAg	p.G42E	SLC8A3_ENST00000534137.1_Missense_Mutation_p.G42E|SLC8A3_ENST00000528359.1_Missense_Mutation_p.G42E|SLC8A3_ENST00000356921.2_Missense_Mutation_p.G42E|SLC8A3_ENST00000357887.3_Missense_Mutation_p.G42E	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	42					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ATTGTTCTGCCCTGTGCTTGG	0.567000													13	42					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93125795	93125795	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93125795C>T	ENST00000216487.7	+	7	2475	c.2316C>T	c.(2314-2316)tcC>tcT	p.S772S	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	772	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				TCTACGACTCCATGGCCCTCG	0.572000													28	95					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43120225	43120225	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43120225G>A	ENST00000267890.6	-	6	546	c.438C>T	c.(436-438)aaC>aaT	p.N146N	TTBK2_ENST00000567840.1_Silent_p.N146N|TTBK2_ENST00000567274.1_Intron	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	146	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CCATAGCGAAGTTCGACTAGA	0.343000													9	63					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64984868	64984868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:64984868C>T	ENST00000394156.3	-	12	2149	c.1696G>A	c.(1696-1698)Gac>Aac	p.D566N	CDH11_ENST00000268603.4_Missense_Mutation_p.D566N|CDH11_ENST00000566827.1_Missense_Mutation_p.D440N			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	566	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AGGTACAAGTCCTGCTTCTGC	0.602000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			8	38					0	0	1	0	0
ULBP2	80328	broad.mit.edu	37	6	150266593	150266593	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:150266593G>A	ENST00000367351.3	+	2	307	c.234G>A	c.(232-234)ggG>ggA	p.G78G		NM_025217.2	NP_079493.1	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2	78	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		GTCCCCTGGGGAAGAAACTAA	0.512000													78	156					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13029765	13029765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:13029765G>A	ENST00000399002.2	+	2	564	c.290G>A	c.(289-291)aGa>aAa	p.R97K	SPTLC3_ENST00000476791.1_3'UTR|SPTLC3_ENST00000378194.4_Missense_Mutation_p.R97K	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	97					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	GCTGTGGAAAGAAAAGAACAA	0.428000													22	79					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133900607	133900607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133900607G>A	ENST00000220616.4	+	10	2595	c.2555G>A	c.(2554-2556)gGg>gAg	p.G852E	TG_ENST00000377869.1_Missense_Mutation_p.G852E	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	852	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCACTGGAAGGGAAACGGCCC	0.537000													19	56					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51697238	51697238	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51697238C>T	ENST00000409535.1	+	22	4331	c.4206C>T	c.(4204-4206)tcC>tcT	p.S1402S	RAD54L2_ENST00000296477.3_Silent_p.S1096S	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	1402						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CTTTTCCTTCCCCTGTCTTGC	0.577000													8	114					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36897586	36897586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36897586G>A	ENST00000301807.6	-	12	3742	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F	TRANK1_ENST00000429976.2_Silent_p.F1165F|TRANK1_ENST00000428977.2_Silent_p.F615F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1165					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAAGCTCAATGAAATTCCTTT	0.483000													54	117					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196801453	196801453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196801453C>T	ENST00000312428.6	-	20	3242	c.3142G>A	c.(3142-3144)Gaa>Aaa	p.E1048K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1048	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCAAAAGTTCATTAGATTTT	0.303000													6	66					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35144275	35144275	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:35144275G>A	ENST00000436258.1	-	0	1791																											GCATATCAAGGAAGCCATAAC	0.388000													12	40					0	0	1	0	0
C5orf58	133874	broad.mit.edu	37	5	169662054	169662054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169662054C>T	ENST00000521850.1	+	2	1826	c.137C>T	c.(136-138)tCg>tTg	p.S46L	C5orf58_ENST00000517575.1_3'UTR|C5orf58_ENST00000593851.1_Missense_Mutation_p.S46L			C9J3I9	CE058_HUMAN	chromosome 5 open reading frame 58	46										large_intestine(1)|lung(4)|urinary_tract(1)	6						ACAATTTCTTCGGAGTTGAAG	0.303000													4	11					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102496012	102496012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102496012G>A	ENST00000260228.2	-	1	51	c.39C>T	c.(37-39)ctC>ctT	p.L13L	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	13					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AAGCCATGATGAGGAAGACAG	0.542000													9	63					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43821548	43821548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43821548G>A	ENST00000382031.1	+	5	8622	c.8591G>A	c.(8590-8592)gGa>gAa	p.G2864E	MAP1A_ENST00000300231.5_Missense_Mutation_p.G2626E|MAP1A_ENST00000399453.1_Missense_Mutation_p.G2626E			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2626						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GATCTTCGGGGAAAACGCTCA	0.657000													32	66					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46930133	46930133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46930133G>A	ENST00000262738.3	-	1	2934	c.2935C>T	c.(2935-2937)Ctt>Ttt	p.L979F	CELSR1_ENST00000395964.1_Missense_Mutation_p.L979F	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	979	Cadherin 7.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GAGGCGCTAAGGGGAGTGGGA	0.567000													17	100					0	0	1	0	0
PSEN2	5664	broad.mit.edu	37	1	227071564	227071564	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:227071564C>T	ENST00000366782.1	+	5	899	c.399C>T	c.(397-399)atC>atT	p.I133I	PSEN2_ENST00000340188.4_Silent_p.I100I|PSEN2_ENST00000422240.2_Silent_p.I100I|PSEN2_ENST00000391872.2_Silent_p.I133I|PSEN2_ENST00000366783.3_Silent_p.I100I			P49810	PSN2_HUMAN	presenilin 2 (Alzheimer disease 4)	100					amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding	p.I100I(1)		cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|urinary_tract(1)	20		Prostate(94;0.0771)				TGTGCATGATCGTGGTGGTAG	0.607000													28	83					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38995970	38995970	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38995970G>A	ENST00000355481.4	+	53	8463	c.8332G>A	c.(8332-8334)Gga>Aga	p.G2778R	RYR1_ENST00000360985.3_Missense_Mutation_p.G2778R|RYR1_ENST00000359596.3_Missense_Mutation_p.G2778R	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2778	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTGGTCCTATGGAGAGAACAT	0.602000													12	20					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202404	56202404	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56202404G>A	ENST00000361673.3	-	5	5228	c.5015C>T	c.(5014-5016)cCa>cTa	p.P1672L		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1672							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTTTTGACATGGATCCTGCAG	0.532000													21	111					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076695	9076695	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9076695G>A	ENST00000397910.4	-	3	10954	c.10751C>T	c.(10750-10752)tCt>tTt	p.S3584F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3585	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGCTGTGGAAGACCAGGTGGA	0.493000													27	69					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955590	18955590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18955590C>T	ENST00000302797.3	-	1	966	c.742G>A	c.(742-744)Gtc>Atc	p.V248I		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	248					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CAAAATAAGACTTCCCTGTCC	0.473000													17	40					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39228062	39228062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39228062C>T	ENST00000340369.3	-	2	3103	c.2875G>A	c.(2875-2877)Gag>Aag	p.E959K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.E959K	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	959							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGGGCCCCCTCGCTGGCTGGC	0.657000													21	58					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87965964	87965964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:87965964C>T	ENST00000369577.3	+	8	2660	c.2617C>T	c.(2617-2619)Cct>Tct	p.P873S	ZNF292_ENST00000339907.4_Missense_Mutation_p.P868S	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ATCTATGCTTCCTTCAGAAAA	0.398000													5	43					0	0	1	0	0
IGLV3-9	28804	broad.mit.edu	37	22	23162204	23162204	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23162204G>A	ENST00000390316.2	+	0	412																											CCCAAGCCGGGGATGAGGCTG	0.557000													21	56					0	0	1	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140865966	140865966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140865966C>T	ENST00000306593.1	+	1	1226	c.1226C>T	c.(1225-1227)aCt>aTt	p.T409I	PCDHGA9_ENST00000573521.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCTGGTGACTGCTGGACCC	0.527000													24	47					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71602047	71602047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71602047C>T	ENST00000355962.4	-	12	1498	c.1365G>A	c.(1363-1365)taG>taA	p.*455*	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	0					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GGATGCAGGCCTATTTATCAC	0.597000													17	59					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215833488	215833488	+	Missense_Mutation	SNP	G	G	A	rs144770649	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215833488G>A	ENST00000272895.7	-	38	5953	c.5734C>T	c.(5734-5736)Cgt>Tgt	p.R1912C	ABCA12_ENST00000389661.4_Missense_Mutation_p.R1594C	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1912					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ATATCAAAACGAAGGTCTTTT	0.338000													41	152					0	0	1	0	0
BMF	90427	broad.mit.edu	37	15	40398107	40398107	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40398107G>A	ENST00000354670.4	-	3	415	c.181C>T	c.(181-183)Cga>Tga	p.R61*	BMF_ENST00000559701.1_Nonsense_Mutation_p.R61*|BMF_ENST00000561360.1_Nonsense_Mutation_p.R61*|BMF_ENST00000431415.3_Nonsense_Mutation_p.R61*|BMF_ENST00000561282.1_Nonsense_Mutation_p.R61*|BMF_ENST00000558774.1_Nonsense_Mutation_p.R61*|BMF_ENST00000220446.4_Nonsense_Mutation_p.R61*|BMF_ENST00000397573.1_Nonsense_Mutation_p.R61*	NM_001003940.1	NP_001003940.1	Q96LC9	BMF_HUMAN	Bcl2 modifying factor	61				R -> Q (in Ref. 4; AAH69328).	activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	6		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		CTGGTGGGTCGAAGGCCAGGG	0.627000													25	60					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126137028	126137028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:126137028G>A	ENST00000299308.3	+	8	1949	c.1941G>A	c.(1939-1941)acG>acA	p.T647T	TMEM132B_ENST00000535886.1_Silent_p.T159T	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	647						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CTGAGAAGACGGTGATTGTCC	0.572000													15	32					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66083828	66083828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66083828G>A	ENST00000311330.3	-	1	687	c.671C>T	c.(670-672)tCa>tTa	p.S224L	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	224	Sushi.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	CCCAGCCCGTGACCAGCCCAC	0.682000													15	56					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583873	88583873	+	Missense_Mutation	SNP	G	G	A	rs149603030		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88583873G>A	ENST00000339673.6	+	6	1042	c.943G>A	c.(943-945)Ggt>Agt	p.G315S	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.G299S|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	315					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding	p.G315S(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		AGACAGCAAGGGTGACTCTCA	0.512000													6	80					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8331622	8331622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8331622C>T	ENST00000381196.4	-	41	6037	c.5494G>A	c.(5494-5496)Gaa>Aaa	p.E1832K	PTPRD_ENST00000358503.5_Missense_Mutation_p.E1810K|PTPRD_ENST00000397611.3_Missense_Mutation_p.E1422K|PTPRD_ENST00000356435.5_Missense_Mutation_p.E1832K|PTPRD_ENST00000397617.3_Missense_Mutation_p.E1425K|PTPRD_ENST00000397606.3_Missense_Mutation_p.E1425K|PTPRD_ENST00000540109.1_Missense_Mutation_p.E1832K|PTPRD_ENST00000360074.4_Missense_Mutation_p.E1819K|PTPRD_ENST00000537002.1_Missense_Mutation_p.E1422K|PTPRD_ENST00000486161.1_Missense_Mutation_p.E1425K|PTPRD_ENST00000355233.5_Missense_Mutation_p.E1426K	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1832	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CCAAACTGTTCTTTTGTTTTA	0.433000										TSP Lung(15;0.13)			33	63					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34782179	34782179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34782179G>A	ENST00000338074.2	+	12	1507	c.1346G>A	c.(1345-1347)gGg>gAg	p.G449E	EPB41L1_ENST00000202028.5_Missense_Mutation_p.G387E|EPB41L1_ENST00000373941.1_Missense_Mutation_p.G449E|EPB41L1_ENST00000441639.1_Missense_Mutation_p.G387E|EPB41L1_ENST00000373946.3_Missense_Mutation_p.G418E|EPB41L1_ENST00000373950.2_Missense_Mutation_p.G352E	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	449					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					CATGATGCAGGGCCTGACGGT	0.602000													9	28					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155250772	155250772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155250772C>T	ENST00000357232.3	-	11	2455	c.2456G>A	c.(2455-2457)cGa>cAa	p.R819Q	DCHS2_ENST00000339452.1_Missense_Mutation_p.R1274Q	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	819	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGTGGCGTTTCGTGGTGGGGA	0.542000													22	41					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73616252	73616252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73616252C>T	ENST00000261917.3	-	8	3175	c.2182G>A	c.(2182-2184)Gac>Aac	p.D728N		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	728					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GAGTTGAGGTCGTGCTGGACT	0.592000													9	115					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169099050	169099050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169099050G>A	ENST00000359299.3	+	8	730	c.544G>A	c.(544-546)Gaa>Aaa	p.E182K		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	182							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		GGTCCTATGGGAAGCCTGTCA	0.502000													18	93					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39885298	39885298	+	Silent	SNP	C	C	T	rs139289744	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39885298C>T	ENST00000260356.5	+	18	3030	c.2865C>T	c.(2863-2865)acC>acT	p.T955T		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	955					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TCAGTGAGACCGATTTCCGCC	0.502000													13	44					0	0	1	0	0
GFRA3	2676	broad.mit.edu	37	5	137600082	137600082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137600082G>A	ENST00000274721.3	-	2	493	c.247C>T	c.(247-249)Cct>Tct	p.P83S	GFRA3_ENST00000378362.3_Missense_Mutation_p.P83S	NM_001496.3	NP_001487.2	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3	83					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CAGTCAGCAGGGACCGAAGGC	0.597000													27	57					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24256502	24256502	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24256502G>A	ENST00000538205.1	+	10	1188	c.641G>A	c.(640-642)tGg>tAg	p.W214*	ADAMDEC1_ENST00000522298.1_Nonsense_Mutation_p.W214*|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000256412.4_Nonsense_Mutation_p.W293*	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	293					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TTCCTGAGATGGCACAGTTCT	0.507000													16	44					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12353605	12353605	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12353605C>T	ENST00000358136.3	+	24	6007	c.5877C>T	c.(5875-5877)ctC>ctT	p.L1959L	VPS13D_ENST00000356315.4_Silent_p.L1959L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1959					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACCCTCTGCTCCGGAGAGAAC	0.483000													10	53					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228309	142228309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142228309G>A	ENST00000519067.1	-	4	1580	c.1277C>T	c.(1276-1278)aCc>aTc	p.T426I	SLC45A4_ENST00000433583.2_Missense_Mutation_p.T419I|SLC45A4_ENST00000024061.3_Missense_Mutation_p.T426I|SLC45A4_ENST00000517878.1_Missense_Mutation_p.T477I			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	477					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GCTGGAGGTGGTGGCCCCGCT	0.677000													6	29					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50367226	50367226	+	Silent	SNP	C	C	T	rs143481476		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50367226C>T	ENST00000315520.5	+	1	607	c.270C>T	c.(268-270)ctC>ctT	p.L90L	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	90					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						TGGCCTTCCTCGTAGGCTCCC	0.667000													22	52					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94548945	94548945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94548945C>T	ENST00000370225.3	-	7	907	c.821G>A	c.(820-822)gGa>gAa	p.G274E	ABCA4_ENST00000535735.1_Missense_Mutation_p.G274E	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	274					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TAATATTCCTCCCCAAGATCT	0.353000													19	339					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117685228	117685228	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117685228G>A	ENST00000317775.6	-	18	3433	c.2748C>T	c.(2746-2748)atC>atT	p.I916I	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.I950I	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	916	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCATCTTCAGGATCCTCTCCC	0.557000													40	85					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231972	7231972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:7231972C>T	ENST00000383467.2	+	1	850	c.836C>T	c.(835-837)cCt>cTt	p.P279L		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	279										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						TTATCCAAGCCTCTGCCGGAG	0.597000													73	196					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3740659	3740659	+	Missense_Mutation	SNP	C	C	T	rs144286949		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3740659C>T	ENST00000541714.2	+	14	2203	c.1741C>T	c.(1741-1743)Cgt>Tgt	p.R581C	TJP3_ENST00000262968.9_Missense_Mutation_p.R614C|TJP3_ENST00000587686.1_Missense_Mutation_p.R600C|TJP3_ENST00000589378.1_Missense_Mutation_p.R590C|TJP3_ENST00000539908.2_Missense_Mutation_p.R545C|TJP3_ENST00000382008.3_Missense_Mutation_p.R595C	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	595						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGGTCTTCGTCGAGGAGC	0.692000													12	18					0	0	1	0	0
SOST	50964	broad.mit.edu	37	17	41836020	41836020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:41836020C>T	ENST00000301691.2	-	1	136	c.90G>A	c.(88-90)aaG>aaA	p.K30K		NM_025237.2	NP_079513.1	Q9BQB4	SOST_HUMAN	sclerostin	30					negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of ossification|negative regulation of protein complex assembly|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway		heparin binding|protein binding			large_intestine(2)|lung(3)|prostate(1)	6		Breast(137;0.00725)		UCEC - Uterine corpus endometrioid carcinoma (308;0.177)|BRCA - Breast invasive adenocarcinoma(366;0.0741)		TGGCATCATTCTTGAACGCCT	0.622000													34	36					0	0	1	0	0
REM1	28954	broad.mit.edu	37	20	30072045	30072045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30072045G>A	ENST00000201979.2	+	5	1002	c.709G>A	c.(709-711)Gag>Aag	p.E237K		NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	237					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CGAGCTCTTCGAGGGCGTGGT	0.701000													6	13					0	0	1	0	0
CYP2A6	1548	broad.mit.edu	37	19	41354158	41354158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41354158C>T	ENST00000301141.5	-	4	640	c.620G>A	c.(619-621)gGa>gAa	p.G207E	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	207					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	CTGGAAGATTCCTAGCATCAT	0.567000													40	110					0	0	1	0	0
TBCB	1155	broad.mit.edu	37	19	36616633	36616633	+	Silent	SNP	C	C	T	rs146159771		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36616633C>T	ENST00000221855.3	+	6	1259	c.684C>T	c.(682-684)gtC>gtT	p.V228V	TBCB_ENST00000586868.1_3'UTR|TBCB_ENST00000589996.1_3'UTR|TBCB_ENST00000585746.1_Silent_p.V177V	NM_001281.2	NP_001272.2	Q99426	TBCB_HUMAN	tubulin folding cofactor B	228					'de novo' posttranslational protein folding|cell differentiation|nervous system development	cytoplasm|microtubule	protein binding			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGCCAGCAGTCGTGACGGTGG	0.572000													97	224					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31422420	31422420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31422420C>T	ENST00000389202.2	+	13	1429	c.1380C>T	c.(1378-1380)tcC>tcT	p.S460S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	460					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TCGGGGCCTCCCTCTGCTCTG	0.662000													20	115					0	0	1	0	0
ATP1A1	476	broad.mit.edu	37	1	116943869	116943869	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:116943869C>T	ENST00000537345.1	+	20	3199	c.2836C>T	c.(2836-2838)Cag>Tag	p.Q946*	ATP1A1_ENST00000369496.4_Nonsense_Mutation_p.Q915*|ATP1A1_ENST00000295598.5_Nonsense_Mutation_p.Q946*	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	946					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TTCGGTCTTCCAGCAGGGGAT	0.488000													8	59					0	0	1	0	0
MAN2C1	4123	broad.mit.edu	37	15	75651681	75651681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75651681G>A	ENST00000565683.1	-	17	2058	c.2047C>T	c.(2047-2049)Cgt>Tgt	p.R683C	MAN2C1_ENST00000563622.1_Silent_p.F579F|MAN2C1_ENST00000267978.5_Silent_p.F678F|MAN2C1_ENST00000569482.1_Silent_p.F678F	NM_001256494.1	NP_001243423.1	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	664					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding			central_nervous_system(4)|endometrium(4)|kidney(6)|large_intestine(6)|lung(20)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	44						CTTGCACTACGAACACAGGCT	0.622000													15	60					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56419205	56419205	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56419205C>T	ENST00000588751.1	-	7	2424	c.2400G>A	c.(2398-2400)ctG>ctA	p.L800L	NLRP13_ENST00000342929.3_Silent_p.L800L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	800							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CTTTAAGAATCAGGGGGACAG	0.498000													40	87					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183605973	183605973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:183605973C>T	ENST00000264065.6	+	13	1496	c.1081C>T	c.(1081-1083)Cgt>Tgt	p.R361C		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	361					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTTTAAGGATCGTTTGGCTCA	0.318000													6	46					0	0	1	0	0
VPS51	738	broad.mit.edu	37	11	64876880	64876880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64876880C>T	ENST00000279281.3	+	6	1664	c.1572C>T	c.(1570-1572)ctC>ctT	p.L524L	VPS51_ENST00000527646.1_3'UTR	NM_013265.2	NP_037397.2			vacuolar protein sorting 51 homolog (S. cerevisiae)																		CTGCCCTGCTCCTGCTGCTCT	0.612000													8	72					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48145489	48145489	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48145489C>T	ENST00000311303.3	-	15	2554	c.2209_splice	c.e15+1	p.V737_splice	ABCC12_ENST00000416054.1_Intron|ABCC12_ENST00000448542.1_Intron	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	737						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GGATTCTAACCGATTATACCA	0.448000													82	339					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40739002	40739002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40739002C>T	ENST00000373198.3	-	24	3526	c.3291G>A	c.(3289-3291)ccG>ccA	p.P1097P	PTPRT_ENST00000373193.3_Silent_p.P1078P|PTPRT_ENST00000373184.1_Silent_p.P1085P|PTPRT_ENST00000373201.1_Silent_p.P1065P|PTPRT_ENST00000373190.1_Silent_p.P1074P|PTPRT_ENST00000373187.1_Silent_p.P1075P|PTPRT_ENST00000356100.2_Silent_p.P1084P	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1075	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCCAGCTTCCGGGGGGTTGA	0.627000													13	50					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8500760	8500760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8500760C>T	ENST00000381196.4	-	21	2665	c.2122G>A	c.(2122-2124)Gaa>Aaa	p.E708K	PTPRD_ENST00000358503.5_Missense_Mutation_p.E695K|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.E708K|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.E708K|PTPRD_ENST00000360074.4_Missense_Mutation_p.E695K|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000355233.5_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	708					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATACCATCTTCATTGGTTCGA	0.488000										TSP Lung(15;0.13)			37	60					0	0	1	0	0
CRYBA4	1413	broad.mit.edu	37	22	27018589	27018589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:27018589G>A	ENST00000354760.3	+	2	64	c.29G>A	c.(28-30)gGa>gAa	p.G10E	CRYBA4_ENST00000466315.1_3'UTR	NM_001886.2	NP_001877.1	P53673	CRBA4_HUMAN	crystallin, beta A4	10	N-terminal arm.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens			large_intestine(6)|liver(1)|lung(6)|skin(3)|urinary_tract(2)	18						AAGTCAGCGGGACCCTGGAAG	0.542000													7	62					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160109744	160109744	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160109744C>T	ENST00000361216.3	+	22	3093	c.3004C>T	c.(3004-3006)Cga>Tga	p.R1002*	ATP1A2_ENST00000392233.3_Nonsense_Mutation_p.R991*	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1002					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.R1002R(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TGATGAGGTCCGAAAGCTCAT	0.582000													29	122					0	0	1	0	0
ZNF18	7566	broad.mit.edu	37	17	11881772	11881772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11881772G>A	ENST00000322748.3	-	9	1756	c.1152C>T	c.(1150-1152)acC>acT	p.T384T	ZNF18_ENST00000454073.3_Silent_p.T383T|ZNF18_ENST00000580306.1_Silent_p.T384T|ZNF18_ENST00000580613.1_Intron	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	384					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		CAAGCCACATGGTGGACATTT	0.532000													19	63					0	0	1	0	0
NRG2	9542	broad.mit.edu	37	5	139231339	139231339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139231339G>A	ENST00000541337.1	-	7	1653	c.1424C>T	c.(1423-1425)tCa>tTa	p.S475L	NRG2_ENST00000340391.3_Missense_Mutation_p.S338L|NRG2_ENST00000361474.1_Missense_Mutation_p.S541L|NRG2_ENST00000545385.1_Missense_Mutation_p.S543L|NRG2_ENST00000394770.1_3'UTR|NRG2_ENST00000289409.4_Missense_Mutation_p.S535L|NRG2_ENST00000289422.7_Missense_Mutation_p.S549L|NRG2_ENST00000358522.3_Missense_Mutation_p.S543L|CTB-35F21.4_ENST00000504413.1_RNA	NM_001184935.1	NP_001171864.1	O14511	NRG2_HUMAN	neuregulin 2	541					embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	25			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTACCCACTGATGATAGCAT	0.632000													18	51					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21136525	21136525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21136525C>T	ENST00000261383.3	-	9	1374	c.1375G>A	c.(1375-1377)Gac>Aac	p.D459N	DNAH3_ENST00000415178.1_Missense_Mutation_p.D459N|CTC-508F8.1_ENST00000575612.1_RNA	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	459	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GAAACGAGGTCCTCAAGTGAC	0.453000													14	88					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651392	1651392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1651392G>A	ENST00000399676.2	+	1	360	c.322G>A	c.(322-324)Gcc>Acc	p.A108T		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	108	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GTCCAAGGGGGCCTGTGGCTC	0.687000													51	108					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21175855	21175855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21175855G>A	ENST00000381541.3	+	5	618	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.E138K|SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.E185K																							TGGCATAGGGGAAACCCCCAT	0.368000													36	101					0	0	1	0	0
RASIP1	54922	broad.mit.edu	37	19	49227976	49227976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49227976C>T	ENST00000222145.4	-	9	2573	c.2369G>A	c.(2368-2370)cGa>cAa	p.R790Q		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	790	Dilute.				signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		ACCTTCACCTCGTTCCATCAG	0.552000													27	95					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38993182	38993182	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38993182G>A	ENST00000355481.4	+	48	7781	c.7650G>A	c.(7648-7650)ctG>ctA	p.L2550L	RYR1_ENST00000360985.3_Silent_p.L2550L|RYR1_ENST00000359596.3_Silent_p.L2550L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2550	6 X approximate repeats.		L -> V.		muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGCTGGCGCTGAACCGCTACC	0.652000													5	25					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285203	223285203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:223285203G>A	ENST00000540964.1	-	4	1632	c.1171C>T	c.(1171-1173)Ctc>Ttc	p.L391F	TLR5_ENST00000342210.6_Missense_Mutation_p.L391F			O60602	TLR5_HUMAN	toll-like receptor 5	391					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		TTGTCTCGGAGATCCAAGGTC	0.373000													8	109					0	0	1	0	0
BCL7A	605	broad.mit.edu	37	12	122481924	122481924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122481924C>T	ENST00000538010.1	+	4	3074	c.404C>T	c.(403-405)gCc>gTc	p.A135V	BCL7A_ENST00000261822.4_Missense_Mutation_p.A135V	NM_020993.3	NP_066273.1	Q4VC05	BCL7A_HUMAN	B-cell CLL/lymphoma 7A	135					negative regulation of transcription, DNA-dependent					haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000202)|Epithelial(86;0.000386)|BRCA - Breast invasive adenocarcinoma(302;0.231)		GTGGATGAGGCCCAGGCTGAT	0.652000			T	MYC	BNHL								8	70					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40947690	40947690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40947690G>A	ENST00000246914.5	+	16	3091	c.3070G>A	c.(3070-3072)Gaa>Aaa	p.E1024K		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1024					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTCATCCAAGGAACCGGCTGA	0.547000													29	29					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41008206	41008206	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41008206C>T	ENST00000352632.3	+	9	1155	c.1069C>T	c.(1069-1071)Ctg>Ttg	p.L357L	SPTBN4_ENST00000344104.3_Silent_p.L357L|SPTBN4_ENST00000595535.1_Silent_p.L357L|SPTBN4_ENST00000598249.1_Silent_p.L357L|SPTBN4_ENST00000338932.3_Silent_p.L357L			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	357					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTATTGCACGCTGGAGAAGCC	0.607000													24	49					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24974859	24974859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:24974859C>T	ENST00000405141.1	+	21	4426	c.3715C>T	c.(3715-3717)Ccc>Tcc	p.P1239S	NCOA1_ENST00000538539.1_Missense_Mutation_p.P1239S|NCOA1_ENST00000406961.1_Missense_Mutation_p.P1239S|NCOA1_ENST00000395856.3_Missense_Mutation_p.P1239S|NCOA1_ENST00000407230.1_Missense_Mutation_p.P1088S|NCOA1_ENST00000348332.3_Missense_Mutation_p.P1239S|NCOA1_ENST00000288599.5_Missense_Mutation_p.P1239S			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	1239									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAATGGTTCCCCAAGGTGA	0.418000			T	PAX3	alveolar rhadomyosarcoma								33	63					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104902005	104902005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:104902005G>A	ENST00000533400.1	-	4	375	c.340C>T	c.(340-342)Cct>Tct	p.P114S	CASP1_ENST00000525825.1_Missense_Mutation_p.P93S|CASP1_ENST00000526568.1_Missense_Mutation_p.P21S|CASP1_ENST00000531166.1_Intron|CASP1_ENST00000527979.1_Missense_Mutation_p.P77S|CASP1_ENST00000393136.4_Missense_Mutation_p.P93S|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000528974.1_Missense_Mutation_p.P75S|CASP1_ENST00000593315.1_Missense_Mutation_p.P93S|CASP1_ENST00000446369.1_Missense_Mutation_p.P21S|CASP1_ENST00000353247.5_Intron|CASP1_ENST00000594519.1_Missense_Mutation_p.P21S|CASP1_ENST00000436863.3_Missense_Mutation_p.P114S|CASP1_ENST00000534497.1_Missense_Mutation_p.P21S|CASP1_ENST00000598974.1_Missense_Mutation_p.P114S	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	114					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	ACTGCCTGAGGAGCTGCAAGA	0.483000													11	33					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156667159	156667159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156667159C>T	ENST00000422843.3	+	10	1091	c.939C>T	c.(937-939)ttC>ttT	p.F313F		NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	313	SH2.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTATGTGTTCGATTCCATCC	0.458000			T	SYK	peripheral T-cell lymphoma								19	81					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70420231	70420231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70420231G>A	ENST00000381280.4	+	3	613	c.360G>A	c.(358-360)gaG>gaA	p.E120E	SMOC1_ENST00000361956.3_Silent_p.E120E	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	120	Thyroglobulin type-1 1.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		AGTGTGGCGAGGATGGCTCCT	0.617000													11	82					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211456679	211456679	+	Missense_Mutation	SNP	G	G	A	rs149930500		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211456679G>A	ENST00000233072.5	+	10	1268	c.1072G>A	c.(1072-1074)Gat>Aat	p.D358N	CPS1_ENST00000430249.2_Missense_Mutation_p.D364N	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	358	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GAATGTCAACGATCAAACAAA	0.378000													8	40					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8435173	8435173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8435173G>A	ENST00000447869.1	-	11	2131	c.1213C>T	c.(1213-1215)Cca>Tca	p.P405S	STK33_ENST00000358872.3_Missense_Mutation_p.P218S|STK33_ENST00000473980.1_5'UTR|STK33_ENST00000534493.1_Missense_Mutation_p.P364S|STK33_ENST00000315204.1_Missense_Mutation_p.P405S|STK33_ENST00000396673.1_Intron|STK33_ENST00000396672.1_Missense_Mutation_p.P405S			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	405						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		ACACTTTCTGGGTTATTTTTC	0.373000													58	124					0	0	1	0	0
CDSN	1041	broad.mit.edu	37	6	31084214	31084214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31084214G>A	ENST00000376288.2	-	2	1204	c.1178C>T	c.(1177-1179)cCc>cTc	p.P393L	PSORS1C1_ENST00000259881.9_Intron|PSORS1C1_ENST00000467107.1_3'UTR	NM_001264.4	NP_001255.3	Q15517	CDSN_HUMAN	corneodesmosin	393	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)	10						AGAACTGGAGGGAGAGCAGGG	0.642000													7	7					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152278088	152278088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152278088C>T	ENST00000368799.1	-	3	9309	c.9274G>A	c.(9274-9276)Gag>Aag	p.E3092K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3092	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGCCTGCTCATGGCGGGAT	0.577000									Ichthyosis				97	263					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117251691	117251691	+	Missense_Mutation	SNP	C	C	T	rs78194216		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117251691C>T	ENST00000003084.6	+	20	3328	c.3196C>T	c.(3196-3198)Cgt>Tgt	p.R1066C	CFTR_ENST00000454343.1_Missense_Mutation_p.R1005C|AC000111.6_ENST00000456270.1_RNA	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1066	ABC transmembrane type-1 2.		R -> C (in CF).|R -> H (in CF).|R -> L (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ATGGACACTTCGTGCCTTCGG	0.413000									Cystic Fibrosis				15	34					0	0	1	0	0
TTC12	54970	broad.mit.edu	37	11	113233182	113233182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113233182C>T	ENST00000393020.1	+	19	2079	c.1674C>T	c.(1672-1674)gcC>gcT	p.A558A	TTC12_ENST00000314756.3_Silent_p.A558A|TTC12_ENST00000483239.2_Silent_p.A564A|TTC12_ENST00000529221.1_Silent_p.A558A			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	558							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TTGAGGAGGCCTTGCGAGCAG	0.418000													33	70					0	0	1	0	0
MIR563	693148	broad.mit.edu	37	3	15915346	15915346	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:15915346C>T	ENST00000385080.1	+	0	69					NR_030289.1																						CATACGTTTCCCTGGTAGCCA	0.383000													36	73					0	0	1	0	0
C11orf65	160140	broad.mit.edu	37	11	108256663	108256663	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108256663A>G	ENST00000525729.1	-	6	693	c.624T>C	c.(622-624)tcT>tcC	p.S208S	C11orf65_ENST00000526725.1_Intron|C11orf65_ENST00000529391.1_Silent_p.S257S|C11orf65_ENST00000393084.1_Silent_p.S257S			Q8NCR3	CK065_HUMAN	chromosome 11 open reading frame 65	257										endometrium(1)|large_intestine(3)|lung(4)|ovary(2)	10		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		AGTTAGCCGAAGAGTTGCTTG	0.333000													17	219					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793298	29793298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29793298C>T	ENST00000269202.6	+	11	1402	c.1355C>T	c.(1354-1356)cCa>cTa	p.P452L	MEP1B_ENST00000581447.1_Missense_Mutation_p.P452L	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	452	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TATAGCCCTCCATTTTACTCT	0.408000													4	31					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21469372	21469372	+	Nonsense_Mutation	SNP	C	C	T	rs1042848		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21469372C>T	ENST00000222584.3	+	3	807	c.589C>T	c.(589-591)Cag>Tag	p.Q197*		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	197			Q -> K (in dbSNP:rs1042848).		regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						GGGTCAAATTCAGCTCATTTC	0.408000													39	89					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73161477	73161477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73161477G>A	ENST00000286657.4	-	19	2653	c.2617C>T	c.(2617-2619)Cgt>Tgt	p.R873C		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	873	TSP type-1 2.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTTTTCCTACGGCATCCATAT	0.368000													28	89					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112777075	112777075	+	Missense_Mutation	SNP	G	G	A	rs147779020	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:112777075G>A	ENST00000295408.4	+	16	2422	c.2165G>A	c.(2164-2166)cGa>cAa	p.R722Q	MERTK_ENST00000421804.2_Missense_Mutation_p.R722Q|MERTK_ENST00000409780.1_Missense_Mutation_p.R546Q			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	722	Protein kinase.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TTTCTTCATCGAGATTTAGCT	0.463000													52	91					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164320	139164320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139164320C>T	ENST00000395297.1	-	13	2568	c.2398G>A	c.(2398-2400)Gat>Aat	p.D800N		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	800										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGTGCATATCTGAAGGTTCA	0.522000										HNSCC(54;0.14)			7	48					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767335	105767335	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:105767335C>T	ENST00000374798.3	+	5	492	c.422C>T	c.(421-423)tCa>tTa	p.S141L	CYLC2_ENST00000487798.1_Missense_Mutation_p.S141L	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	141	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				aaaaaagattcaaagaaaggc	0.353000													8	31					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2297770	2297770	+	Silent	SNP	C	C	T	rs139192773		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2297770C>T	ENST00000381458.5	+	6	789	c.726C>T	c.(724-726)acC>acT	p.T242T	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	242					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	GCACTTACACCGGTGGCCGGG	0.537000													35	112					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857389	9857389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9857389C>T	ENST00000396573.2	-	14	4321	c.4012G>A	c.(4012-4014)Ggg>Agg	p.G1338R	GRIN2A_ENST00000404927.2_Intron|GRIN2A_ENST00000562109.1_Intron|GRIN2A_ENST00000330684.3_Missense_Mutation_p.G1338R|GRIN2A_ENST00000396575.2_Missense_Mutation_p.G1338R|GRIN2A_ENST00000535259.1_Intron	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1338					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTTTTTTTCCCCGAGAGTTTG	0.547000													17	83					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101350846	101350846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101350846C>T	ENST00000534062.1	-	1	338	c.280G>A	c.(280-282)Gac>Aac	p.D94N	MIR432_ENST00000606207.1_RNA	NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	94										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TGGAGTAGGTCATTGGGTGGA	0.532000													40	56					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74536357	74536357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74536357C>T	ENST00000321288.5	+	4	662	c.662C>T	c.(661-663)gCc>gTc	p.A221V	CCDC33_ENST00000398814.3_Missense_Mutation_p.A18V			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	221							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CCCCTGATCGCCTCCCAGAGC	0.557000													34	159					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95422344	95422344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95422344G>A	ENST00000371447.3	+	20	2449	c.2311G>A	c.(2311-2313)Gaa>Aaa	p.E771K	PDE6C_ENST00000475427.2_3'UTR	NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	771					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				CAAAAGAGATGAATTACCTAA	0.279000													15	57					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46827113	46827113	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46827113G>A	ENST00000283296.7	-	17	2815	c.2527C>T	c.(2527-2529)Cct>Tct	p.P843S	GPR116_ENST00000265417.7_Missense_Mutation_p.P843S|GPR116_ENST00000456426.2_Missense_Mutation_p.P701S|GPR116_ENST00000362015.4_Missense_Mutation_p.P843S|GPR116_ENST00000545669.1_Missense_Mutation_p.P272S	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	843					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			AAGGACAAAGGAGGGCTATCT	0.448000													20	40					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155232579	155232579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155232579G>A	ENST00000460012.1	-	12	1832	c.1475C>T	c.(1474-1476)cCt>cTt	p.P492L	PLCH1_ENST00000334686.6_Missense_Mutation_p.P492L|PLCH1_ENST00000494598.1_Missense_Mutation_p.P510L|PLCH1_ENST00000447496.2_Missense_Mutation_p.P510L|PLCH1_ENST00000340059.7_Missense_Mutation_p.P510L|PLCH1_ENST00000414191.1_Missense_Mutation_p.P492L			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	510					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GAAACTATCAGGATCTTCTTT	0.428000													13	46					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987554	61987554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61987554C>T	ENST00000450719.3	-	3	394	c.157G>A	c.(157-159)Gac>Aac	p.D53N	CSHL1_ENST00000346606.6_Missense_Mutation_p.D53N|CSHL1_ENST00000561003.1_Missense_Mutation_p.D64N|CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000438387.2_Missense_Mutation_p.D64N|CSHL1_ENST00000259003.10_Missense_Mutation_p.D85N|CSHL1_ENST00000309894.5_Missense_Mutation_p.D147N			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	147						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						TCCTCTAGGTCCTTTAGGAGG	0.592000													7	79					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106841174	106841174	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:106841174C>T	ENST00000276185.4	+	15	2164	c.2164C>T	c.(2164-2166)Cag>Tag	p.Q722*				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	722						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						CCGGGCTGTCCAGAGCCAGGA	0.567000													35	14					0	0	1	0	0
PDXDC1	23042	broad.mit.edu	37	16	15122865	15122865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15122865C>T	ENST00000455313.2	+	14	1386	c.1266C>T	c.(1264-1266)gtC>gtT	p.V422V	PDXDC1_ENST00000450288.2_Intron|PDXDC1_ENST00000447912.2_Intron|PDXDC1_ENST00000325823.7_Intron|PDXDC1_ENST00000396410.4_Intron|PDXDC1_ENST00000535621.2_Intron|PDXDC1_ENST00000563679.1_Intron|PDXDC1_ENST00000569715.1_Intron			Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain containing 1	0					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	AGGTCCCCGTCCATCACCATC	0.637000													6	25					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130319507	130319507	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130319507C>T	ENST00000299164.2	+	1	639	c.639C>T	c.(637-639)ttC>ttT	p.F213F		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	213					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCAAGCGTTTCGTGTCTATCC	0.667000													7	6					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44673674	44673674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44673674C>T	ENST00000454036.1	+	12	1609	c.1533C>T	c.(1531-1533)gtC>gtT	p.V511V	SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000243964.3_Silent_p.V488V	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	511					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GGGTAATTGTCATCGGATCCT	0.612000													48	176					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149356757	149356757	+	Missense_Mutation	SNP	G	G	A	rs72645628	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:149356757G>A	ENST00000355292.3	-	2	1618	c.1256C>T	c.(1255-1257)tCg>tTg	p.S419L	NR3C2_ENST00000512865.1_Missense_Mutation_p.S419L|NR3C2_ENST00000344721.4_Missense_Mutation_p.S419L|NR3C2_ENST00000511528.1_Missense_Mutation_p.S419L|NR3C2_ENST00000358102.3_Missense_Mutation_p.S419L|NR3C2_ENST00000342437.4_Missense_Mutation_p.S419L			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	419	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TGAAGAATCCGAATTTATTTT	0.393000													24	107					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713517	142713517	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:142713517C>T	ENST00000369381.2	-	0	1088																											TTCACACTTTCACTGTGTTTA	0.368000													11	73					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44639787	44639787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44639787C>T	ENST00000372330.3	+	5	674	c.655C>T	c.(655-657)Cca>Tca	p.P219S		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	219					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TGCAGTGGTTCCAACTCGGTT	0.632000													115	281					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51380010	51380010	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51380010G>A	ENST00000325321.3	+	3	714	c.489G>A	c.(487-489)gaG>gaA	p.E163E	KLK2_ENST00000358049.4_Silent_p.E163E|KLK2_ENST00000391810.2_Silent_p.E61E			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	163	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		TCGAACCAGAGGAGTGTACGC	0.642000			T	ETV4	prostate								11	34					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128990073	128990073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128990073G>A	ENST00000274487.4	+	14	2378	c.2233G>A	c.(2233-2235)Gga>Aga	p.G745R	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	745	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G745R(1)		NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AGTGATGGATGGAACTTCTTG	0.353000													13	95					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10079083	10079083	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10079083G>A	ENST00000264828.3	-	59	4377	c.4292C>T	c.(4291-4293)cCc>cTc	p.P1431L		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1431	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGGACCAGGGGGTCCCTGCAC	0.597000													72	172					0	0	1	0	0
RPL18	6141	broad.mit.edu	37	19	49120585	49120585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49120585G>A	ENST00000549273.1	-	3	219	c.186C>T	c.(184-186)tcC>tcT	p.S62S	RPL18_ENST00000552588.1_Silent_p.S33S|RPL18_ENST00000550645.1_Silent_p.S62S|RPL18_ENST00000549920.1_Silent_p.S62S			Q07020	RL18_HUMAN	ribosomal protein L18	62				S -> C (in Ref. 3; AAH21743).	endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			cervix(1)|kidney(2)	3		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)		TCCGGGAAAGGGACAGAGGCG	0.562000													56	167					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137623485	137623485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137623485G>A	ENST00000371817.3	+	8	1722	c.1308G>A	c.(1306-1308)gcG>gcA	p.A436A		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	436	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding	p.A436A(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GAATGCCGGCGAACCAGGATA	0.637000													14	97					0	0	1	0	0
IGKV5-2	28907	broad.mit.edu	37	2	89197096	89197096	+	RNA	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89197096A>G	ENST00000390244.2	+	0	204																											AAGCCAGCCAAGACATTGATG	0.463000													7	107					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55216156	55216156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55216156G>A	ENST00000340465.2	+	5	562	c.476G>A	c.(475-477)gGa>gAa	p.G159E		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	159						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TCAGCAAATGGAAATCCGTGT	0.453000													74	213					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119943026	119943026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119943026G>A	ENST00000327554.2	+	7	1266	c.801G>A	c.(799-801)gtG>gtA	p.V267V	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	267										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCCCAAGTGTGAACACCCAGG	0.552000													56	199					0	0	1	0	0
DYNLRB2	83657	broad.mit.edu	37	16	80583494	80583494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:80583494G>A	ENST00000305904.6	+	3	313	c.193G>A	c.(193-195)Gac>Aac	p.D65N	DYNLRB2_ENST00000568035.1_Intron|DYNLRB2_ENST00000570222.1_3'UTR|RP11-525K10.3_ENST00000568776.1_RNA|DYNLRB2_ENST00000562982.1_Missense_Mutation_p.D94N|RP11-109P11.1_ENST00000568275.1_RNA	NM_130897.1	NP_570967.1	Q8TF09	DLRB2_HUMAN	dynein, light chain, roadblock-type 2	65					microtubule-based movement|transport	cytoplasmic dynein complex|microtubule	microtubule motor activity			large_intestine(1)|lung(4)|prostate(1)	6						TCCTCAGAACGACCTGACTTT	0.383000													20	51					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3834911	3834911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3834911C>T	ENST00000262961.4	-	2	134	c.124G>A	c.(124-126)Gac>Aac	p.D42N	ZFR2_ENST00000591965.1_5'UTR	NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	42						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		ACGGCAGGGTCCATCCCAGGA	0.667000													6	9					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124268560	124268560	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124268560G>A	ENST00000409039.3	+	8	908	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	295	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGCGCTGCATGAACAAACAAA	0.443000													23	52					0	0	1	0	0
HMP19	51617	broad.mit.edu	37	5	173473792	173473792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:173473792G>A	ENST00000303177.3	+	2	296	c.34G>A	c.(34-36)Gga>Aga	p.G12R	NSG2_ENST00000521585.1_Missense_Mutation_p.G12R	NM_015980.4	NP_057064.1																					CAGCGAGAAGGGAACCAAGCC	0.532000													39	103					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15996760	15996760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15996760C>T	ENST00000221700.5	-	9	1184	c.1089G>A	c.(1087-1089)aaG>aaA	p.K363K	CYP4F2_ENST00000592328.1_Silent_p.K363K|CYP4F2_ENST00000011989.7_3'UTR	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	363					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GCTCACGGTCCTTCAGAAGTT	0.577000													32	79					0	0	1	0	0
FFAR2	2867	broad.mit.edu	37	19	35940700	35940700	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35940700C>T	ENST00000599180.1	+	2	164	c.84C>T	c.(82-84)gcC>gcT	p.A28A	FFAR2_ENST00000246549.2_Silent_p.A28A|FFAR2_ENST00000601590.1_Intron			O15552	FFAR2_HUMAN	free fatty acid receptor 2	28						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			ACCTCCTGGCCCTGCGGGCCT	0.632000													14	79					0	0	1	0	0
ZBTB32	27033	broad.mit.edu	37	19	36207515	36207515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36207515C>T	ENST00000392197.2	+	7	1643	c.1325C>T	c.(1324-1326)tCc>tTc	p.S442F	ZBTB32_ENST00000262630.3_Missense_Mutation_p.S442F			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	442					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGCCTGGCCTCCATGCAGGCG	0.711000											OREG0025433	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	69					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71871187	71871187	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71871187C>T	ENST00000258104.3	+	41	4780	c.4503C>T	c.(4501-4503)acC>acT	p.T1501T	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Silent_p.T1502T|DYSF_ENST00000409744.1_Silent_p.T1509T|DYSF_ENST00000410020.3_Silent_p.T1540T|DYSF_ENST00000413539.2_Silent_p.T1532T|DYSF_ENST00000429174.2_Silent_p.T1522T|DYSF_ENST00000409366.1_Silent_p.T1523T|DYSF_ENST00000409582.3_Silent_p.T1539T|DYSF_ENST00000409762.1_Silent_p.T1518T|DYSF_ENST00000409651.1_Silent_p.T1533T|DYSF_ENST00000410041.1_Silent_p.T1519T	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1501						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATTTTGACACCCTGAAGGTAA	0.507000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575593	179575593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179575593C>T	ENST00000589042.1	-	98	28455	c.28231G>A	c.(28231-28233)Gga>Aga	p.G9411R	TTN_ENST00000342992.6_Missense_Mutation_p.G8167R|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G9094R|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9094	Ig-like 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACTTTCTCCCACCACAGCA	0.512000													16	63					0	0	1	0	0
SYPL2	284612	broad.mit.edu	37	1	110019517	110019517	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110019517C>T	ENST00000369872.3	+	4	590	c.374C>T	c.(373-375)tCc>tTc	p.S125F	SYPL2_ENST00000401021.3_Missense_Mutation_p.S125F	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	125	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGCATCTTTTCCTTCTTCTAT	0.552000													28	61					0	0	1	0	0
PODXL	5420	broad.mit.edu	37	7	131195771	131195771	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131195771C>T	ENST00000541194.1	-	2	785	c.528G>A	c.(526-528)aaG>aaA	p.K176K	PODXL_ENST00000378555.3_Silent_p.K174K|PODXL_ENST00000322985.9_Silent_p.K174K|PODXL_ENST00000537928.1_Silent_p.K174K	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	174	Thr-rich.				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					GATGTTCTGCCTTAGTGGATG	0.547000													46	189					0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19378100	19378100	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:19378100G>T	ENST00000550708.1	+	1	579	c.507G>T	c.(505-507)ctG>ctT	p.L169L		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTGGATTTCTGTGGTTCCTGA	0.488000													28	146					8.73648e-17	8.7853e-17	1	1	0
PROSER1	80209	broad.mit.edu	37	13	39597240	39597240	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39597240G>A	ENST00000352251.3	-	8	1425	c.592C>T	c.(592-594)Cct>Tct	p.P198S	PROSER1_ENST00000350125.3_Missense_Mutation_p.P176S|PROSER1_ENST00000484434.2_Intron	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	198	Pro-rich.																TAAGGAACAGGTTTATGTGGA	0.378000													16	136					0	0	1	0	0
KLHL5	51088	broad.mit.edu	37	4	39083717	39083717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39083717C>T	ENST00000261425.3	+	5	990	c.838C>T	c.(838-840)Cgt>Tgt	p.R280C	KLHL5_ENST00000508137.2_Missense_Mutation_p.R139C|KLHL5_ENST00000261426.5_Missense_Mutation_p.R265C|KLHL5_ENST00000359687.2_Missense_Mutation_p.R326C|KLHL5_ENST00000381930.3_Missense_Mutation_p.R326C|KLHL5_ENST00000504108.1_Missense_Mutation_p.R326C	NM_001007075.2	NP_001007076.1	Q96PQ7	KLHL5_HUMAN	kelch-like family member 5	326	BTB.					cytoplasm|cytoskeleton	actin binding	p.R326C(3)|p.R326G(1)		endometrium(3)|kidney(1)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29						TCTTGGAATTCGTTCTTTTGC	0.393000													72	221					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46727878	46727878	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46727878G>A	ENST00000318962.4	-	6	669	c.586C>T	c.(586-588)Ctg>Ttg	p.L196L	ALS2CL_ENST00000415953.1_Silent_p.L196L	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	196					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AAGGACTGCAGGTTCCCAAAG	0.617000													20	55					0	0	1	0	0
HPD	3242	broad.mit.edu	37	12	122292683	122292683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122292683C>T	ENST00000543163.1	-	8	668	c.223G>A	c.(223-225)Ggc>Agc	p.G75S	HPD_ENST00000289004.4_Missense_Mutation_p.G114S	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	114					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	ATTTTGGCGCCCCGTTCCCGT	0.602000													15	112					0	0	1	0	0
TRPV3	162514	broad.mit.edu	37	17	3458126	3458126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3458126C>T	ENST00000301365.4	-	2	150	c.19G>A	c.(19-21)Gag>Aag	p.E7K	TRPV3_ENST00000572519.1_Missense_Mutation_p.E7K|TRPV3_ENST00000576742.1_Missense_Mutation_p.E7K			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	7						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	GGCACCATCTCCTTGGGGTGG	0.622000													13	24					0	0	1	0	0
IGHG4	3503	broad.mit.edu	37	14	106091705	106091705	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106091705C>T	ENST00000390543.2	-	0	306																											CATGGGGGACCATATTTGGAC	0.592000													60	140					0	0	1	0	0
GATM	2628	broad.mit.edu	37	15	45669010	45669010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45669010C>T	ENST00000396659.3	-	2	416	c.77G>A	c.(76-78)cGa>cAa	p.R26Q	GATM_ENST00000558336.1_Missense_Mutation_p.R26Q	NM_001482.2	NP_001473.1	P50440	GATM_HUMAN	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	26					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	15		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	TGTCAAGGTTCGTCCAAGCTT	0.488000													6	21					0	0	1	0	0
DSCR4	10281	broad.mit.edu	37	21	39492501	39492501	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39492501C>T	ENST00000328264.3	-	2	234	c.128_splice	c.e2-1	p.E44_splice	DSCR4_ENST00000398948.1_Splice_Site_p.E44_splice	NM_005867.2	NP_005858.1	P56555	DSCR4_HUMAN	Down syndrome critical region gene 4	44										large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	6						attttttcttctctaggaaaa	0.413000													24	44					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38591833	38591833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38591833C>T	ENST00000413689.1	-	28	6223	c.6030G>A	c.(6028-6030)agG>agA	p.R2010R	SCN5A_ENST00000423572.2_Silent_p.R2009R|SCN5A_ENST00000425664.1_Silent_p.R1992R|SCN5A_ENST00000455624.2_Silent_p.R1977R|SCN5A_ENST00000450102.2_Silent_p.R1956R|SCN5A_ENST00000449557.2_Silent_p.R1956R|SCN5A_ENST00000414099.2_Silent_p.R1992R|SCN5A_ENST00000451551.2_Silent_p.R1956R|SCN5A_ENST00000333535.4_Silent_p.R2010R|SCN5A_ENST00000443581.1_Silent_p.R2009R	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	2010					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACTCACGGTCCCTGTCCGGAG	0.567000													39	88					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47561043	47561043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47561043G>A	ENST00000273859.3	+	13	2807	c.2538G>A	c.(2536-2538)aaG>aaA	p.K846K	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	846					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GTATAGCAAAGAAGGTGAGAC	0.428000													17	86					0	0	1	0	0
OR2T8	343172	broad.mit.edu	37	1	248084349	248084349	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248084349C>T	ENST00000319968.4	+	1	30	c.30C>T	c.(28-30)ttC>ttT	p.F10F		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCTCTTATTTCATTCTCCTAG	0.413000													31	84					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71003055	71003055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71003055G>A	ENST00000334414.6	-	4	817	c.773C>T	c.(772-774)tCt>tTt	p.S258F	PTPRB_ENST00000550857.1_Missense_Mutation_p.S40F|PTPRB_ENST00000451516.2_Missense_Mutation_p.S40F|PTPRB_ENST00000551525.1_Missense_Mutation_p.S257F|PTPRB_ENST00000550358.1_Missense_Mutation_p.S258F|PTPRB_ENST00000538708.1_Missense_Mutation_p.S40F|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000261266.5_Missense_Mutation_p.S40F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	40	Fibronectin type-III 3.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GATAGACACAGAATGGCTGGA	0.527000													12	47					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130855747	130855747	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130855747C>T	ENST00000245255.3	+	20	2620	c.2348C>T	c.(2347-2349)gCt>gTt	p.A783V	PIWIL1_ENST00000541480.1_3'UTR	NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	783	Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GTGAGCCAGGCTGTGAGAAGT	0.443000													63	112					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27206694	27206694	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27206694C>T	ENST00000380036.4	+	15	2921	c.2479C>T	c.(2479-2481)Caa>Taa	p.Q827*	TEK_ENST00000519097.1_Nonsense_Mutation_p.Q679*|TEK_ENST00000406359.4_Nonsense_Mutation_p.Q784*	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	827	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CATCAAATTTCAAGATGTGAT	0.453000													9	45					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627428	43627428	+	Missense_Mutation	SNP	G	G	A	rs11261835	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:43627428G>A	ENST00000332857.6	-	4	1287	c.1259C>T	c.(1258-1260)cCc>cTc	p.P420L		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6									p.P420L(1)									GTGCAGAGAGGGGAGGCCCCA	0.498000													10	183					0	0	1	0	0
C3orf67	200844	broad.mit.edu	37	3	58855057	58855057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58855057G>A	ENST00000472469.1	-	8	1235	c.397C>T	c.(397-399)Cat>Tat	p.H133Y	C3orf67_ENST00000482387.1_Missense_Mutation_p.H213Y|RP11-147N17.1_ENST00000492031.1_RNA|C3orf67_ENST00000295966.7_Missense_Mutation_p.H213Y|RP11-147N17.1_ENST00000463703.1_RNA|RP11-147N17.1_ENST00000493123.1_RNA|RP11-147N17.1_ENST00000482372.1_RNA			Q6ZVT6	CC067_HUMAN	chromosome 3 open reading frame 67	213										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		TTCTTACCATGAATAGGTACA	0.328000													17	70					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51205785	51205785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51205785C>T	ENST00000293441.1	-	11	1704	c.1686G>A	c.(1684-1686)gtG>gtA	p.V562V	SHANK1_ENST00000359082.3_Silent_p.V562V|SHANK1_ENST00000391814.1_Silent_p.V562V	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	562	SH3.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGTAGGACTTCACAGCCATGA	0.697000													3	23					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136536720	136536720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136536720C>T	ENST00000371872.4	-	18	2520	c.2263G>A	c.(2263-2265)Ggt>Agt	p.G755S	SARDH_ENST00000439388.1_Missense_Mutation_p.G755S|SARDH_ENST00000371868.1_Missense_Mutation_p.G183S|SARDH_ENST00000422262.2_Missense_Mutation_p.G587S	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	755					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGCTTGGCACCCGCGGCCATC	0.667000													4	14					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	57002771	57002771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57002771G>A	ENST00000371250.3	-	2	704	c.153C>T	c.(151-153)ttC>ttT	p.F51F		NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	51					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						CGATGATGAGGAAGGGGAGGC	0.458000													20	74					0	0	1	0	0
CADM4	199731	broad.mit.edu	37	19	44127496	44127496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44127496C>T	ENST00000222374.2	-	9	1201	c.1153G>A	c.(1153-1155)Gaa>Aaa	p.E385K		NM_145296.1	NP_660339.1	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4	385					cell adhesion	integral to membrane				endometrium(2)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	12		Prostate(69;0.0199)				ATGAAGAATTCCTCTTTCCTC	0.577000													44	105					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92606763	92606763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92606763C>T	ENST00000342818.3	+	7	1161	c.925C>T	c.(925-927)Cag>Tag	p.Q309*	BTBD8_ENST00000540648.1_Intron	NM_183242.3	NP_899065.2	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	309						nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		TAATTTCTTTCAGAAGGTAAT	0.299000													26	56					0	0	1	0	0
AGL	178	broad.mit.edu	37	1	100330033	100330033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100330033C>T	ENST00000294724.4	+	5	1030	c.552C>T	c.(550-552)gaC>gaT	p.D184D	AGL_ENST00000361522.4_Silent_p.D167D|AGL_ENST00000370163.3_Silent_p.D184D|AGL_ENST00000361915.3_Silent_p.D184D|AGL_ENST00000370161.2_Silent_p.D168D|AGL_ENST00000361302.3_Silent_p.D168D|AGL_ENST00000370165.3_Silent_p.D184D	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	184					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TAAATCCTGACTTTTCAAGAC	0.368000													28	115					0	0	1	0	0
DCLK2	166614	broad.mit.edu	37	4	151153862	151153862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:151153862C>T	ENST00000296550.7	+	10	2202	c.1448C>T	c.(1447-1449)tCg>tTg	p.S483L	DCLK2_ENST00000506325.1_Missense_Mutation_p.S482L|DCLK2_ENST00000302176.8_Missense_Mutation_p.S500L	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	483	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity	p.S500L(1)|p.S483L(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					GCAATTACTTCGTCGACCAAG	0.448000													45	210					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49166090	49166090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49166090G>A	ENST00000307885.4	-	17	3469	c.2775C>T	c.(2773-2775)ctC>ctT	p.L925L	ADCY6_ENST00000357869.3_Silent_p.L872L|ADCY6_ENST00000550422.1_Silent_p.L872L	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	925					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GTAGTTTCCAGAGGAAGTCTA	0.567000													12	79					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43625382	43625382	+	Missense_Mutation	SNP	G	G	A	rs143826416	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:43625382G>A	ENST00000332857.6	-	4	3333	c.3305C>T	c.(3304-3306)cCt>cTt	p.P1102L		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		CTTGTGAATAGGGGGAAACAT	0.483000													8	102					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48391896	48391896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48391896G>A	ENST00000435803.1	+	31	10524	c.10500G>A	c.(10498-10500)gtG>gtA	p.V3500V		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3500					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GAACAGATGTGGTAAAAAACC	0.453000													31	61					0	0	1	0	0
BGN	633	broad.mit.edu	37	X	152770723	152770723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:152770723C>T	ENST00000331595.4	+	3	452	c.266C>T	c.(265-267)tCc>tTc	p.S89F	BGN_ENST00000480756.1_3'UTR|BGN_ENST00000370204.1_Missense_Mutation_p.S28F	NM_001711.4	NP_001702.1	P21810	PGS1_HUMAN	biglycan	89						proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AAAGAGATCTCCCCTGACACC	0.597000													34	27					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156727807	156727807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156727807C>T	ENST00000347377.6	+	6	903	c.472C>T	c.(472-474)Ctc>Ttc	p.L158F	CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000377576.3_Missense_Mutation_p.L158F|CYFIP2_ENST00000318218.6_Missense_Mutation_p.L158F|CYFIP2_ENST00000541131.1_Missense_Mutation_p.L83F|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000521420.1_Missense_Mutation_p.L132F	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	158					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGAGGCCTACCTCCTGACCCT	0.572000													13	26					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169985	113169985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113169985C>T	ENST00000401783.2	-	38	8231	c.7895G>A	c.(7894-7896)gGa>gAa	p.G2632E	SVEP1_ENST00000374469.1_Missense_Mutation_p.G2609E|SVEP1_ENST00000297826.5_Missense_Mutation_p.G558E	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2632					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTCAAAATATCCCTGGTCATC	0.438000													53	213					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63700140	63700140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:63700140G>A	ENST00000279873.7	+	3	885	c.475G>A	c.(475-477)Gac>Aac	p.D159N		NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	159					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CAACTTCAAAGACGTTCTCAA	0.438000													5	26					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1217051	1217051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1217051C>T	ENST00000304460.10	+	8	1220	c.1164C>T	c.(1162-1164)ttC>ttT	p.F388F		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	388					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCAACGCCTTCCTCTCAGAGG	0.662000													41	86					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57293412	57293412	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57293412G>A	ENST00000391708.3	-	10	1097	c.555C>T	c.(553-555)ttC>ttT	p.F185F	ZIM2_ENST00000593711.1_Silent_p.F185F|ZIM2_ENST00000601070.1_Silent_p.F185F|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000599935.1_Silent_p.F185F|ZIM2_ENST00000221722.5_Silent_p.F185F	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		CCTCTGGGCTGAAGTCCACAA	0.507000													51	119					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21755884	21755884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:21755884G>A	ENST00000382254.1	-	14	2787	c.1701C>T	c.(1699-1701)ctC>ctT	p.L567L	RP11-804N13.1_ENST00000522350.1_RNA|CDH12_ENST00000504376.2_Silent_p.L567L|CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000522262.1_Silent_p.L527L	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	567	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TTACAACAGGGAGGAAATACA	0.453000										HNSCC(59;0.17)			33	22					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751993	140751993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140751993C>T	ENST00000576222.1	+	1	2163	c.2032C>T	c.(2032-2034)Cgc>Tgc	p.R678C	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTAGCGACCGCCCCACTCC	0.557000													24	97					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436749	248436749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248436749G>A	ENST00000318021.2	-	1	389	c.368C>T	c.(367-369)gCt>gTt	p.A123V		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTGGCAGACAGCCGCATAGCG	0.607000													21	111					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26676281	26676281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26676281G>A	ENST00000288710.2	+	14	1857	c.1783G>A	c.(1783-1785)Gag>Aag	p.E595K		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		gacggagatggagggagaaaa	0.572000													26	68					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542206	133542206	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133542206T>A	ENST00000409261.1	-	14	2551	c.2178A>T	c.(2176-2178)gcA>gcT	p.A726A	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Silent_p.A726A	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	726							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TATAGTCTCTTGCAGCAGCTC	0.408000													7	89					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48936095	48936095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48936095C>T	ENST00000294954.7	-	8	693	c.672G>A	c.(670-672)ccG>ccA	p.P224P	STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Silent_p.P224P|LHCGR_ENST00000401907.1_Silent_p.P224P|LHCGR_ENST00000403273.1_Silent_p.P224P|LHCGR_ENST00000344775.3_Silent_p.P224P	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	224					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	ACAAGGTTTTCGGCCCTGTGG	0.547000													48	121					0	0	1	0	0
SPATA31D4	389761	broad.mit.edu	37	9	84549011	84549011	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84549011G>A	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							CAAAGAGAGTGAGCCCTTTAA	0.507000													4	9					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644414	169644414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169644414C>T	ENST00000428432.2	+	6	753	c.364C>T	c.(364-366)Cta>Tta	p.L122L	SAMD7_ENST00000335556.3_Silent_p.L122L	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	122										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			ACTAGCAGGCCTAGGGATACC	0.468000													35	68					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152325151	152325151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152325151C>T	ENST00000388718.5	-	3	5183	c.5111G>A	c.(5110-5112)aGa>aAa	p.R1704K	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1704							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGGGCATGTCTAGTGGTATC	0.493000													116	389					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69376695	69376695	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:69376695G>A	ENST00000193403.6	-	5	875	c.492C>T	c.(490-492)gtC>gtT	p.V164V	ACTN1_ENST00000554508.1_5'UTR|ACTN1_ENST00000438964.2_Silent_p.V164V|ACTN1_ENST00000376839.3_Silent_p.V99V|ACTN1_ENST00000538545.2_Silent_p.V164V|ACTN1_ENST00000394419.4_Silent_p.V164V	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	164	Actin-binding.|CH 2.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TCTGGATGTTGACATTTTTGT	0.592000													30	71					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774646	140774646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140774646G>A	ENST00000398604.2	+	1	2266	c.2266G>A	c.(2266-2268)Gaa>Aaa	p.E756K	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATTCCCAGGAAGTCTCCCT	0.562000													13	110					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77762534	77762534	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77762534C>T	ENST00000521891.2	+	9	4348	c.3900C>T	c.(3898-3900)gcC>gcT	p.A1300A	ZFHX4_ENST00000050961.6_Silent_p.A1255A|ZFHX4_ENST00000455469.2_Silent_p.A1255A|ZFHX4_ENST00000518282.1_Silent_p.A1274A	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1255						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGCAGCTGCCTCTGAGAAAT	0.478000										HNSCC(33;0.089)			10	14					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24170931	24170931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24170931C>T	ENST00000265769.4	+	6	524	c.414C>T	c.(412-414)taC>taT	p.Y138Y	ADAM28_ENST00000540823.1_Intron|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Silent_p.Y138Y|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	138					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATCAAAGATACTTTATTGAAC	0.403000													13	58					0	0	1	0	0
CSN1S1	1446	broad.mit.edu	37	4	70810661	70810661	+	Missense_Mutation	SNP	G	G	A	rs149927680	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70810661G>A	ENST00000246891.4	+	15	545	c.496G>A	c.(496-498)Gac>Aac	p.D166N	CSN1S1_ENST00000505782.1_Missense_Mutation_p.D150N|CSN1S1_ENST00000507763.1_Missense_Mutation_p.D157N|CSN1S1_ENST00000507772.1_Missense_Mutation_p.D158N|CSN1S1_ENST00000444405.3_Missense_Mutation_p.D157N	NM_001890.1	NP_001881.1	P47710	CASA1_HUMAN	casein alpha s1	166						extracellular region	protein binding|transporter activity			lung(5)|prostate(1)|upper_aerodigestive_tract(1)	7						ACCGTTTTCCGACATCTCCAA	0.418000													15	224					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76232504	76232504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:76232504C>T	ENST00000298832.9	+	20	2013	c.1808C>T	c.(1807-1809)tCc>tTc	p.S603F	TTLL5_ENST00000557636.1_Missense_Mutation_p.S617F|TTLL5_ENST00000556893.1_Missense_Mutation_p.S154F|TTLL5_ENST00000555422.1_3'UTR|TTLL5_ENST00000554510.1_Missense_Mutation_p.S112F	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	603					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		CAGGAGGCTTCCCAGGAGGAG	0.403000													20	39					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96076520	96076520	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:96076520C>T	ENST00000343702.4	-	7	1921	c.1473G>A	c.(1471-1473)tgG>tgA	p.W491*	NTN4_ENST00000538383.1_Nonsense_Mutation_p.W454*|NTN4_ENST00000553059.1_Nonsense_Mutation_p.W491*|NTN4_ENST00000344911.4_Nonsense_Mutation_p.W454*	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	491					axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						GCGCATCCTCCCACTCCCAGG	0.463000													14	55					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21470000	21470000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21470000C>T	ENST00000313654.9	+	42	5570	c.5329C>T	c.(5329-5331)Ccc>Tcc	p.P1777S	LAMA3_ENST00000587184.1_Missense_Mutation_p.P168S|LAMA3_ENST00000269217.6_Missense_Mutation_p.P168S|LAMA3_ENST00000399516.3_Missense_Mutation_p.P1777S	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1777	Domain III A.|Laminin EGF-like 14.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTCGGGAATCCCCAGAAATT	0.493000													35	120					0	0	1	0	0
ZNF837	116412	broad.mit.edu	37	19	58879844	58879844	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58879844G>A	ENST00000427624.2	-	3	1178	c.856C>T	c.(856-858)Ctg>Ttg	p.L286L	ZNF837_ENST00000597582.1_Silent_p.L286L			Q96EG3	ZN837_HUMAN	zinc finger protein 837	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|skin(1)	2						TGCTGCAGCAGGCTGGAGGTG	0.701000													4	7					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132047130	132047130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:132047130G>A	ENST00000336375.5	+	2	230	c.140G>A	c.(139-141)cGa>cAa	p.R47Q	ACPP_ENST00000475741.1_Missense_Mutation_p.R47Q|ACPP_ENST00000489084.1_3'UTR|ACPP_ENST00000351273.7_Missense_Mutation_p.R47Q	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	47						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						CATGGAGACCGAAGTCCCATT	0.433000													20	52					0	0	1	0	0
GATA6	2627	broad.mit.edu	37	18	19751212	19751212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:19751212C>T	ENST00000269216.3	+	2	384	c.107C>T	c.(106-108)cCt>cTt	p.P36L	GATA6_ENST00000581694.1_Missense_Mutation_p.P36L	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	36					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			TCCACGCCGCCTTCCCCCATC	0.736000													15	23					0	0	1	0	0
METTL24	728464	broad.mit.edu	37	6	110620340	110620340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110620340C>T	ENST00000338882.4	-	4	570	c.571G>A	c.(571-573)Gat>Aat	p.D191N		NM_001123364.1	NP_001116836.1	Q5JXM2	CF186_HUMAN	methyltransferase like 24	191						extracellular region											AAATGGGTATCATCACTTCCT	0.433000													32	40					0	0	1	0	0
CHRM5	1133	broad.mit.edu	37	15	34356394	34356394	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34356394C>T	ENST00000383263.5	+	3	2146	c.1476C>T	c.(1474-1476)ccC>ccT	p.P492P	CHRM5_ENST00000557872.1_Silent_p.P492P	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	492					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	CTGTCAACCCCATCTGCTATG	0.478000													23	74					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29044228	29044228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29044228C>T	ENST00000257189.4	+	9	1237	c.1154C>T	c.(1153-1155)cCt>cTt	p.P385L		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	385					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCATTCCGTCCTGCTTCCAAG	0.393000													20	70					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43268136	43268136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43268136G>A	ENST00000404209.4	-	2	458	c.362C>T	c.(361-363)aCc>aTc	p.T121I	PSG8_ENST00000406636.3_Intron|PSG8_ENST00000401467.2_Missense_Mutation_p.T121I|PSG8_ENST00000306511.4_Missense_Mutation_p.T121I	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	121	Ig-like V-type.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GATGTGTAAGGTGTAGGATCC	0.443000													144	569					0	0	1	0	0
GNAT2	2780	broad.mit.edu	37	1	110148694	110148694	+	Silent	SNP	G	G	T	rs140231308		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110148694G>T	ENST00000351050.3	-	6	804	c.618C>A	c.(616-618)tcC>tcA	p.S206S		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	206					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		TCTTTCTCTCGGATCTCTGCC	0.502000													30	63					1.61788e-16	1.62681e-16	1	1	0
PER2	8864	broad.mit.edu	37	2	239162337	239162337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239162337G>A	ENST00000254657.3	-	19	2606	c.2327C>T	c.(2326-2328)cCt>cTt	p.P776L	AC096574.4_ENST00000456601.1_RNA|PER2_ENST00000254658.3_3'UTR	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	776					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		TCTTAGTCCAGGGGCAGCTAA	0.413000													10	12					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44235853	44235853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44235853G>A	ENST00000330884.4	-	3	473	c.353C>T	c.(352-354)cCc>cTc	p.P118L	SULT4A1_ENST00000249130.5_Missense_Mutation_p.P118L|SULT4A1_ENST00000540422.1_Intron	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	118					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GAGGTCAGAGGGCAGAAAGCG	0.597000													5	12					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132232403	132232403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132232403G>A	ENST00000265343.5	-	11	2298	c.1919C>T	c.(1918-1920)tCa>tTa	p.S640L	AFF4_ENST00000378595.3_Missense_Mutation_p.S640L	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	640					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GATTTCCCTTGATTTCTGGGA	0.423000													11	64					0	0	1	0	0
USP51	158880	broad.mit.edu	37	X	55513532	55513532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:55513532G>A	ENST00000500968.3	-	2	1923	c.1841C>T	c.(1840-1842)tCc>tTc	p.S614F	USP51_ENST00000586165.1_5'UTR	NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	614					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						CAAGGGAAAGGAGATAAAGGT	0.433000													7	22					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639174	7639174	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7639174G>A	ENST00000359156.4	-	10	2581	c.2379C>T	c.(2377-2379)tcC>tcT	p.S793S	CD163_ENST00000432237.2_Silent_p.S793S|CD163_ENST00000396620.3_Silent_p.S826S|CD163_ENST00000541972.1_Silent_p.S781S	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	793	SRCR 7.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GCCAAATGCGGGATTCTTTTC	0.507000													67	170					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167814979	167814979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167814979C>T	ENST00000367848.1	-	21	3050	c.2553G>A	c.(2551-2553)aaG>aaA	p.K851K	ADCY10_ENST00000545172.1_Silent_p.K790K|ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Silent_p.K943K			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	943					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTCTCTGGTCCTTGAGCCACA	0.498000													8	98					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10599661	10599661	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:10599661C>T	ENST00000226951.6	-	3	263	c.24G>A	c.(22-24)aaG>aaA	p.K8K	CLNK_ENST00000442825.2_5'UTR|CLNK_ENST00000507719.1_5'UTR	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	8					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						CTTTAGTTGTCTTTCTATTGC	0.338000													7	12					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49390836	49390836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49390836G>A	ENST00000421952.2	-	2	1844	c.1823C>T	c.(1822-1824)gCc>gTc	p.A608V		NM_015086.1	NP_055901.2	O94850	DEND_HUMAN	dendrin	608	Interaction with CD2AP and NPHS1 (By similarity).					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						CAGGGCCCCGGCGTAGGGCCC	0.736000													4	11					0	0	1	0	0
U66061.31	0	broad.mit.edu	37	7	142424724	142424724	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142424724C>T	ENST00000506718.1	+	0	1590																											CTGCAGCTGGCTGTGCAGCAC	0.478000													5	7					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206331108	206331108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206331108G>A	ENST00000361052.3	+	9	1247	c.1129G>A	c.(1129-1131)Gat>Aat	p.D377N	CTSE_ENST00000360218.2_Silent_p.G324G|CTSE_ENST00000358184.2_Missense_Mutation_p.D372N|CTSE_ENST00000432969.2_Silent_p.G249G			P14091	CATE_HUMAN	cathepsin E	377					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GATCCTGGGGGATGTCTTCAT	0.562000													55	129					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480282	140480282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140480282C>T	ENST00000231130.2	+	1	49	c.49C>T	c.(49-51)Ctc>Ttc	p.L17F	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		17					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTCTTGCTTCTCTTTGTTTT	0.502000													8	68					0	0	1	0	0
SLC37A1	54020	broad.mit.edu	37	21	43959657	43959657	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43959657A>T	ENST00000352133.2	+	6	1368	c.386A>T	c.(385-387)tAc>tTc	p.Y129F	SLC37A1_ENST00000398341.3_Missense_Mutation_p.Y129F			P57057	GLPT_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 1	129					carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						ATTAGGTATTACCTAACTTTC	0.507000													23	75					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102441	22102441	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22102441G>A	ENST00000542433.1	-	1	655	c.558C>T	c.(556-558)atC>atT	p.I186I		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		ATACTGCGCGGATGTCACAGA	0.547000													14	120					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39581281	39581281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39581281G>A	ENST00000265707.5	+	19	2077	c.2032G>A	c.(2032-2034)Gaa>Aaa	p.E678K	ADAM18_ENST00000541111.1_Missense_Mutation_p.E92K|ADAM18_ENST00000379866.1_Missense_Mutation_p.E654K|ADAM18_ENST00000523755.1_3'UTR	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	678					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CTTTTATACTGAAAAAGGCTA	0.299000													35	71					0	0	1	0	0
EXOC3L2	90332	broad.mit.edu	37	19	45731469	45731469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45731469C>T	ENST00000413988.1	-	3	186	c.146G>A	c.(145-147)gGg>gAg	p.G49E	EXOC3L2_ENST00000252482.3_Missense_Mutation_p.G49E	NM_138568.3	NP_612635.3	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	49										endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		CTCCAGGCTCCCCCAGTGCTC	0.667000													49	109					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36340552	36340552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36340552C>T	ENST00000378910.5	-	6	611	c.612G>A	c.(610-612)gtG>gtA	p.V204V	NPHS1_ENST00000353632.6_Silent_p.V204V	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	204	Ig-like C2-type 2.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCCGGGGTGTCACCCTGGGAT	0.552000													19	64					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534248	92534248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92534248C>T	ENST00000298047.6	+	9	8086	c.8069C>T	c.(8068-8070)tCc>tTc	p.S2690F	FAT3_ENST00000409404.2_Missense_Mutation_p.S2690F|FAT3_ENST00000525166.1_Missense_Mutation_p.S2540F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2690	Cadherin 24.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTAAAGCACTCCCTCATTCCT	0.448000										TCGA Ovarian(4;0.039)			14	35					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58551905	58551905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58551905C>T	ENST00000282326.1	+	4	705	c.458C>T	c.(457-459)cCa>cTa	p.P153L		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	153					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CAGAAAGAACCATCGCAGGTG	0.622000													29	115					0	0	1	0	0
IL13	3596	broad.mit.edu	37	5	131995155	131995155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131995155G>A	ENST00000304506.3	+	2	234	c.220G>A	c.(220-222)Gct>Act	p.A74T	IL13_ENST00000468334.1_3'UTR|AC004041.2_ENST00000435042.1_RNA	NM_002188.2	NP_002179.2	P35225	IL13_HUMAN	interleukin 13	74					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			large_intestine(1)|lung(1)|ovary(1)|skin(3)	6		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAACCTGACAGCTGGCATGGT	0.602000													3	17					0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202457675	202457675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202457675C>T	ENST00000406302.3	+	14	2018	c.1865C>T	c.(1864-1866)cCt>cTt	p.P622L	PPP1R12B_ENST00000391959.3_5'UTR|PPP1R12B_ENST00000336894.4_Missense_Mutation_p.P622L|PPP1R12B_ENST00000290419.5_3'UTR|PPP1R12B_ENST00000367270.4_5'UTR	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B	622					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			TATCTGACTCCTGTACGGGAT	0.428000													4	21					0	0	1	0	0
ITPK1	3705	broad.mit.edu	37	14	93483112	93483112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93483112G>A	ENST00000267615.6	-	4	328	c.155C>T	c.(154-156)cCc>cTc	p.P52L	ITPK1_ENST00000555495.1_5'UTR|ITPK1_ENST00000354313.3_Missense_Mutation_p.P52L|ITPK1_ENST00000556603.2_Missense_Mutation_p.P52L|ITPK1_ENST00000556954.1_5'UTR			Q13572	ITPK1_HUMAN	inositol-tetrakisphosphate 1-kinase	52					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)	11		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		GACGTCCAGGGGGCCCTGCTC	0.577000													22	81					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60695935	60695935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:60695935G>A	ENST00000335712.6	-	3	646	c.419C>T	c.(418-420)cCt>cTt	p.P140L	BCL11A_ENST00000359629.5_Missense_Mutation_p.P140L|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Intron|BCL11A_ENST00000537768.1_5'UTR|BCL11A_ENST00000358510.4_Intron|BCL11A_ENST00000356842.4_Missense_Mutation_p.P140L	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	140	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGCAGAACGAGGGGAGGAGAG	0.473000			T	IGH@	B-CLL								6	64					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13678033	13678033	+	Silent	SNP	C	C	T	rs17854691		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13678033C>T	ENST00000404922.3	+	17	3422	c.3303C>T	c.(3301-3303)ttC>ttT	p.F1101F	FBLN2_ENST00000295760.7_Silent_p.F1054F|FBLN2_ENST00000535798.1_Silent_p.F1080F|FBLN2_ENST00000492059.1_Silent_p.F1101F	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	1054	Domain III.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent	p.F520F(1)|p.F1101F(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GCCTGCGCTTCGAGTGTCCTC	0.592000													8	19					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28209208	28209208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:28209208G>A	ENST00000344423.5	-	7	1168	c.1037C>T	c.(1036-1038)cCt>cTt	p.P346L	ZNF395_ENST00000523095.1_Missense_Mutation_p.P346L|ZNF395_ENST00000523202.1_Missense_Mutation_p.P346L	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	346					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGGAGTCCCAGGGACTGGGGT	0.627000													11	98					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103029809	103029809	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103029809G>A	ENST00000306312.3	-	13	1635	c.1374C>T	c.(1372-1374)ctC>ctT	p.L458L	SLC26A5_ENST00000393723.1_Intron|SLC26A5_ENST00000393727.1_Silent_p.L458L|SLC26A5_ENST00000393729.1_Silent_p.L421L|SLC26A5_ENST00000393730.1_Intron|SLC26A5_ENST00000393735.2_Silent_p.L458L|SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000339444.6_Silent_p.L458L|SLC26A5_ENST00000432958.2_Intron	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	458					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						AGAAAAAGGGGAGATCTGAGA	0.438000													28	73					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124253009	124253009	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124253009G>A	ENST00000375013.2	-	1	249	c.231C>T	c.(229-231)ttC>ttT	p.F77F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F77L(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TTTTGGGAGTGAAAACAGAGG	0.388000													49	115					0	0	1	0	0
FBXW11	23291	broad.mit.edu	37	5	171318532	171318532	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:171318532A>T	ENST00000296933.6	-	6	1059	c.689T>A	c.(688-690)gTc>gAc	p.V230D	FBXW11_ENST00000425623.2_Missense_Mutation_p.V211D|FBXW11_ENST00000522891.1_5'UTR|FBXW11_ENST00000265094.5_Missense_Mutation_p.V243D|FBXW11_ENST00000393802.2_Missense_Mutation_p.V209D	NM_033644.2|NM_033645.2	NP_387448.2|NP_387449.2	Q9UKB1	FBW1B_HUMAN	F-box and WD repeat domain containing 11	243					cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of circadian rhythm|positive regulation of proteolysis|positive regulation of transcription, DNA-dependent|protein dephosphorylation|protein destabilization|protein polyubiquitination|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	centrosome|cytosol|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(2)|urinary_tract(2)	21	Renal(175;0.000159)|Lung NSC(126;0.00384)|all_lung(126;0.00659)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TAAACAGTAGACACCTTTACT	0.373000													21	51					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884347	228884347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228884347G>A	ENST00000392056.3	-	7	1269	c.1223C>T	c.(1222-1224)tCt>tTt	p.S408F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S408F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	408						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTGAGATTGAGATAATCTAAT	0.438000													26	91					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958354	121958354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121958354G>A	ENST00000379692.4	-	4	1298	c.772C>T	c.(772-774)Cct>Tct	p.P258S	NDNF_ENST00000506900.1_5'UTR	NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	258										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						TTATCAGAAGGAAATCCAAAG	0.468000													23	44					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68631940	68631940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68631940C>T	ENST00000423218.2	-	11	1269	c.1174G>A	c.(1174-1176)Gga>Aga	p.G392R	ITGA11_ENST00000315757.7_Missense_Mutation_p.G392R			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	392					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	AGCACAGCTCCATTCCAGTCA	0.587000													43	55					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957581	49957581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:49957581C>T	ENST00000376056.2	-	5	1906	c.1756G>A	c.(1756-1758)Gca>Aca	p.A586T	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Missense_Mutation_p.A212T|AKAP4_ENST00000358526.2_Missense_Mutation_p.A595T|AKAP4_ENST00000376064.3_Missense_Mutation_p.A586T			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	595					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					ACTGAAAGTGCTTTGGCACTT	0.468000													39	33					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44587924	44587924	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44587924G>A	ENST00000322927.2	-	15	2269	c.2169C>T	c.(2167-2169)ttC>ttT	p.F723F	ZNF335_ENST00000426788.1_Silent_p.F568F	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	723					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GCAGAGAGAAGAAGGGGCGAC	0.657000													5	79					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35644168	35644168	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:35644168C>T	ENST00000540320.1	+	9	1897	c.1363C>T	c.(1363-1365)Cag>Tag	p.Q455*	NBEA_ENST00000379939.2_Nonsense_Mutation_p.Q455*|NBEA_ENST00000310336.4_Nonsense_Mutation_p.Q455*|NBEA_ENST00000400445.3_Nonsense_Mutation_p.Q455*			Q8NFP9	NBEA_HUMAN	neurobeachin	455						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CACTGATGCTCAGCTCTGCCT	0.413000													14	20					0	0	1	0	0
GNA12	2768	broad.mit.edu	37	7	2770902	2770902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2770902G>A	ENST00000275364.3	-	4	1221	c.1059C>T	c.(1057-1059)gcC>gcT	p.A353A	GNA12_ENST00000407653.1_Silent_p.A277A|AMZ1_ENST00000489665.1_Intron|GNA12_ENST00000544127.1_Silent_p.A260A|GNA12_ENST00000396960.3_Silent_p.A205A|GNA12_ENST00000407904.3_Silent_p.A294A|GNA12_ENST00000491117.1_5'UTR	NM_007353.2	NP_031379.2	Q03113	GNA12_HUMAN	guanine nucleotide binding protein (G protein) alpha 12	353					G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)		CGGTGTCGATGGCGGTGGTGA	0.597000													26	57					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102548620	102548620	+	Silent	SNP	G	G	A	rs113093780		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102548620G>A	ENST00000334701.7	-	11	2564	c.2283C>T	c.(2281-2283)gaC>gaT	p.D761D	HSP90AA1_ENST00000216281.8_Silent_p.D639D	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	639					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	TAATGGAATGGTCAGGGTTTA	0.448000													97	232					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	138011385	138011385	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138011385C>T	ENST00000252854.4	+	6	952	c.765C>T	c.(763-765)ttC>ttT	p.F255F	OLFM1_ENST00000371793.3_Silent_p.F273F|OLFM1_ENST00000371796.3_Silent_p.F246F	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	273	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		ACAACCGCTTCGTACGTGAGT	0.567000													27	60					0	0	1	0	0
PER2	8864	broad.mit.edu	37	2	239169470	239169470	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239169470G>A	ENST00000254657.3	-	13	1820	c.1542_splice	c.e13+1	p.A514_splice	PER2_ENST00000254658.3_3'UTR	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	514					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		GAGACGTACGGCTCTCCTCCG	0.567000													128	342					0	0	1	0	0
SLC25A15	10166	broad.mit.edu	37	13	41379284	41379284	+	Silent	SNP	C	C	T	rs35434090	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:41379284C>T	ENST00000338625.4	+	4	581	c.345C>T	c.(343-345)ttC>ttT	p.F115F	SLC25A15_ENST00000478827.1_3'UTR	NM_014252.3	NP_055067.1	Q9Y619	ORNT1_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	115					cellular amino acid metabolic process|mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|stomach(1)|urinary_tract(1)	14		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.48e-08)|Epithelial(112;7.51e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000191)|GBM - Glioblastoma multiforme(144;0.00231)|BRCA - Breast invasive adenocarcinoma(63;0.0704)	L-Ornithine(DB00129)	CCGGTTCCTTCGCCTCTGCCT	0.547000													10	103					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48145556	48145556	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48145556G>A	ENST00000405493.2	-	4	413	c.204C>T	c.(202-204)gcC>gcT	p.A68A	RAPGEF3_ENST00000549151.1_Silent_p.A68A|RAPGEF3_ENST00000548919.1_Silent_p.A68A|RAPGEF3_ENST00000389212.3_Silent_p.A110A|RAPGEF3_ENST00000171000.4_Silent_p.A68A|RAPGEF3_ENST00000395358.3_Silent_p.A110A|RAPGEF3_ENST00000449771.2_Silent_p.A110A	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	68					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		TTGGGCAGGTGGCCAGCAGAT	0.627000													12	43					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86370529	86370529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:86370529C>T	ENST00000400286.2	-	2	713	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	39	LRRNT 1.					integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CCATCTTTTTCCTCACAATTG	0.393000													31	130					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72299375	72299375	+	Missense_Mutation	SNP	C	C	T	rs144093353		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72299375C>T	ENST00000263563.6	+	15	2033	c.1765C>T	c.(1765-1767)Ccc>Tcc	p.P589S		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		AAGCGAGCCTCCCCCAGGCAA	0.652000													18	51					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240404	126240404	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126240404T>A	ENST00000394329.3	+	1	2851	c.2838T>A	c.(2836-2838)aaT>aaA	p.N946K		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	946	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATGAAAAGAATGGCACTATTA	0.488000													18	43					0	0	1	0	0
TSHR	7253	broad.mit.edu	37	14	81422098	81422098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81422098C>T	ENST00000541158.2	+	2	396	c.74C>T	c.(73-75)tCg>tTg	p.S25L	TSHR_ENST00000342443.6_Missense_Mutation_p.S25L|TSHR_ENST00000298171.2_Missense_Mutation_p.S25L|TSHR_ENST00000557096.1_3'UTR|TSHR_ENST00000554435.1_Missense_Mutation_p.S25L|TSHR_ENST00000554263.1_Missense_Mutation_p.S25L			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	25					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	ATGGGGTGTTCGTCTCCACCC	0.607000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						42	99					0	0	1	0	0
FRK	2444	broad.mit.edu	37	6	116277770	116277770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116277770G>A	ENST00000606080.1	-	5	1249	c.803C>T	c.(802-804)tCa>tTa	p.S268L	FRK_ENST00000538210.1_Missense_Mutation_p.S126L	NM_002031.2	NP_002022.1	P42685	FRK_HUMAN	fyn-related kinase	268	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|skin(1)|urinary_tract(1)	27		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TGGATCCATTGAACCTGAAAC	0.433000													29	35					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61414215	61414215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61414215G>A	ENST00000395348.3	-	5	1205	c.569C>T	c.(568-570)cCc>cTc	p.P190L	SLC16A9_ENST00000395347.1_Missense_Mutation_p.P190L	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	190					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						AGATTGGAGGGGTCTCATCAG	0.408000													43	110					0	0	1	0	0
SEC23IP	11196	broad.mit.edu	37	10	121652342	121652342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:121652342C>T	ENST00000369075.3	+	1	120	c.48C>T	c.(46-48)tcC>tcT	p.S16S	SEC23IP_ENST00000543134.1_5'UTR	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	16	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CCTCCACTTCCTCATCGGGCA	0.627000													8	32					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50249785	50249785	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50249785C>T	ENST00000246801.3	-	6	1016	c.934G>A	c.(934-936)Ggc>Agc	p.G312S	TSKS_ENST00000358830.3_Missense_Mutation_p.G112S	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	312							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		ACGTAGGGGCCCTCGCCAGCC	0.701000													17	62					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64892501	64892501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:64892501G>A	ENST00000555709.1	+	10	1296	c.909G>A	c.(907-909)tgG>tgA	p.W303*	CTD-2555O16.2_ENST00000556640.1_RNA|MTHFD1_ENST00000545908.1_Nonsense_Mutation_p.W359*|MTHFD1_ENST00000216605.7_Nonsense_Mutation_p.W359*|MTHFD1_ENST00000555252.1_Nonsense_Mutation_p.W283*	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	303	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding	p.W303*(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CAGGAAAGTGGATGATTCAGT	0.338000													37	80					0	0	1	0	0
KRT39	390792	broad.mit.edu	37	17	39122681	39122681	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39122681T>A	ENST00000355612.2	-	1	463	c.428A>T	c.(427-429)tAc>tTc	p.Y143F	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	143	Coil 1B.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				GTAAGACAGGTAATCAGGACA	0.413000													46	74					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44932910	44932910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44932910C>T	ENST00000291187.4	-	6	2350	c.2028G>A	c.(2026-2028)aaG>aaA	p.K676K	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Silent_p.K682K	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	682					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				ACGTATAGGGCTTTTTTCCCG	0.502000													47	117					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61802491	61802491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61802491C>T	ENST00000280772.1	-	43	13283	c.13092G>A	c.(13090-13092)acG>acA	p.T4364T	ANK3_ENST00000503366.1_Silent_p.T1855T|ANK3_ENST00000373827.2_Silent_p.T1848T|ANK3_ENST00000355288.2_Silent_p.T988T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4364					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTCTTTCTTCGTTTTCACCT	0.398000													49	145					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564328	176564328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176564328G>A	ENST00000367662.3	+	3	2752	c.1588G>A	c.(1588-1590)Gtg>Atg	p.V530M	PAPPA2_ENST00000367661.3_Missense_Mutation_p.V530M	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	530	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CTACCAGGTGGTGAACATCTG	0.527000													6	39					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886862	3886862	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3886862G>A	ENST00000319331.3	+	2	1298	c.537G>A	c.(535-537)ttG>ttA	p.L179L	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	179						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCAACAAATTGAAAGTTATTG	0.383000													56	167					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152402475	152402475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152402475C>T	ENST00000427231.2	-	135	20706	c.20504G>A	c.(20503-20505)cGa>cAa	p.R6835Q	NEB_ENST00000409198.1_Missense_Mutation_p.R5134Q|NEB_ENST00000397345.3_Missense_Mutation_p.R6835Q|NEB_ENST00000604864.1_Missense_Mutation_p.R6835Q|NEB_ENST00000172853.10_Missense_Mutation_p.R5134Q|NEB_ENST00000603639.1_Missense_Mutation_p.R6835Q	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	5134					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTATTTGTCTCGCATCTTCCT	0.343000													7	13					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108156525	108156525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108156525C>T	ENST00000273353.3	-	26	3213	c.3157G>A	c.(3157-3159)Gag>Aag	p.E1053K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1053						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GCTTTTCTCTCCTGCTCAAGG	0.423000													18	179					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233272030	233272030	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233272030C>T	ENST00000295453.3	+	3	271	c.219C>T	c.(217-219)atC>atT	p.I73I		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	73					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CTGCCAGGATCCTAAAAGGGC	0.602000													26	51					0	0	1	0	0
RARRES3	5920	broad.mit.edu	37	11	63313703	63313703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63313703G>A	ENST00000255688.3	+	4	518	c.470G>A	c.(469-471)aGa>aAa	p.R157K	RARRES3_ENST00000354445.2_Missense_Mutation_p.R157K|RARRES3_ENST00000537871.1_3'UTR	NM_004585.3	NP_004576.2	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene induced) 3	157					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			kidney(1)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	6						GCGATTAGGAGATACCAAAAA	0.532000													59	152					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95147382	95147382	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:95147382C>T	ENST00000354268.4	+	3	376	c.303C>T	c.(301-303)gtC>gtT	p.V101V	SMARCAD1_ENST00000457823.2_Silent_p.V101V			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	101					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		GTGAAGATGTCGTTTCCCCAA	0.303000													55	111					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215914768	215914768	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215914768C>T	ENST00000366943.2	-	60	12046	c.11660G>A	c.(11659-11661)tGg>tAg	p.W3887*	USH2A_ENST00000307340.3_Nonsense_Mutation_p.W3887*			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3887	Fibronectin type-III 24.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGTGGCATCCACTTAATCTC	0.383000										HNSCC(13;0.011)			44	117					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94463552	94463552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94463552C>T	ENST00000370225.3	-	48	6680	c.6594G>A	c.(6592-6594)caG>caA	p.Q2198Q	ABCA4_ENST00000535881.1_Silent_p.Q317Q|ABCA4_ENST00000536513.1_Silent_p.Q468Q	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	2198					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GCCTCTCCCTCTGCACACTGC	0.567000													26	40					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72086592	72086592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72086592G>A	ENST00000265381.4	-	4	1538	c.1316C>T	c.(1315-1317)tCa>tTa	p.S439L		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	439	Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GGTTGGGAATGAAGCCAAGCT	0.353000													27	57					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371658	240371658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240371658G>A	ENST00000319653.9	+	5	3776	c.3546G>A	c.(3544-3546)gtG>gtA	p.V1182V		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1182	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TACCTGGAGTGGGAATACCTC	0.682000													5	53					0	0	1	0	0
CES2	8824	broad.mit.edu	37	16	66975410	66975410	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66975410C>T	ENST00000317091.4	+	7	2093	c.1107_splice	c.e7-1	p.P370_splice	CES2_ENST00000417689.1_Splice_Site_p.P370_splice	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	306					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		TCCCCTCAGCCTTTCAAGATG	0.572000													22	49					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22700095	22700095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:22700095G>A	ENST00000376603.2	+	10	1820	c.1678G>A	c.(1678-1680)Gaa>Aaa	p.E560K	SPAG6_ENST00000376601.1_Missense_Mutation_p.E245K|SPAG6_ENST00000538630.1_Missense_Mutation_p.E459K|SPAG6_ENST00000490361.1_3'UTR|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376624.3_Missense_Mutation_p.E484K|SPAG6_ENST00000313311.6_Intron			O75602	SPAG6_HUMAN	sperm associated antigen 6	484					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						TTACCCCGAGGAAATAGTGAG	0.363000													17	52					0	0	1	0	0
NFKB2	4791	broad.mit.edu	37	10	104159900	104159900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104159900C>T	ENST00000369966.3	+	15	1783	c.1533C>T	c.(1531-1533)atC>atT	p.I511I	NFKB2_ENST00000189444.6_Silent_p.I511I|NFKB2_ENST00000428099.1_Silent_p.I511I	NM_001077494.2	NP_001070962.1	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	511					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|skin(2)	23		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		TCTATGTCATCCACCACGCCC	0.632000			T	IGH@	B-NHL								7	67					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120491725	120491725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120491725G>A	ENST00000256646.2	-	16	2723	c.2504C>T	c.(2503-2505)gCt>gTt	p.A835V		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	835	EGF-like 22.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGAACAGGGAGCCAATACTGT	0.413000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome		OREG0013733	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	95					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46832474	46832474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46832474C>T	ENST00000339613.2	+	12	1538	c.1283C>T	c.(1282-1284)gCt>gTt	p.A428V	HIF3A_ENST00000244303.6_Missense_Mutation_p.A415V|HIF3A_ENST00000420102.2_Missense_Mutation_p.A433V|AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000600383.1_Missense_Mutation_p.A415V|HIF3A_ENST00000472815.1_Intron|HIF3A_ENST00000300862.3_Missense_Mutation_p.A482V|HIF3A_ENST00000377670.4_Missense_Mutation_p.A484V			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	484					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GATGCTGATGCTCTGGATTTG	0.582000													32	76					0	0	1	0	0
CETN1	1068	broad.mit.edu	37	18	580498	580498	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:580498G>A	ENST00000327228.3	+	1	132	c.90G>A	c.(88-90)aaG>aaA	p.K30K		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	30	EF-hand 1.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						AGGATCAGAAGCAAGAAGTTC	0.592000													16	29					0	0	1	0	0
PDS5B	23047	broad.mit.edu	37	13	33327494	33327494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33327494G>A	ENST00000315596.10	+	25	2947	c.2761G>A	c.(2761-2763)Gtg>Atg	p.V921M		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	921					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AGTAAGACAAGTGTTTGCCCA	0.383000													38	98					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131666102	131666102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:131666102C>T	ENST00000368648.3	-	9	901	c.829G>A	c.(829-831)Gac>Aac	p.D277N	EBF3_ENST00000355311.5_Missense_Mutation_p.D286N	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	286	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AAGAAGTTGTCGCCAATTATG	0.567000													34	38					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45557701	45557701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45557701C>T	ENST00000415258.1	+	16	2118	c.1977C>T	c.(1975-1977)atC>atT	p.I659I	LARS2_ENST00000414984.1_Silent_p.I616I|LARS2_ENST00000467936.1_3'UTR|LARS2_ENST00000265537.3_Silent_p.I659I			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	659					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	AGTATGGGATCGACACGATTC	0.483000													42	99					0	0	1	0	0
NXPH1	30010	broad.mit.edu	37	7	8790821	8790821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:8790821G>A	ENST00000405863.1	+	3	1149	c.238G>A	c.(238-240)Gaa>Aaa	p.E80K	NXPH1_ENST00000497400.1_3'UTR|NXPH1_ENST00000602349.1_5'UTR	NM_152745.2	NP_689958.1	P58417	NXPH1_HUMAN	neurexophilin 1	80	II.					extracellular region				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|ovary(1)	17		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		TGACACCCCAGAACCTTATTC	0.507000													30	40					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58155425	58155425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58155425C>T	ENST00000295956.4	+	45	7691	c.7526C>T	c.(7525-7527)tCc>tTc	p.S2509F	FLNB_ENST00000358537.3_Missense_Mutation_p.S2485F|FLNB_ENST00000429972.2_Missense_Mutation_p.S2498F|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000490882.1_Missense_Mutation_p.S2540F|FLNB_ENST00000484981.1_3'UTR|FLNB_ENST00000348383.5_Missense_Mutation_p.S2468F|FLNB-AS1_ENST00000488720.1_RNA|FLNB_ENST00000419752.2_Missense_Mutation_p.S2329F|FLNB_ENST00000493452.1_Missense_Mutation_p.S2316F	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2509	Interaction with FLNA 2.|Interaction with INPPL1.|Self-association site, tail (By similarity).				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCCAAGGCATCCTCGGACGCC	0.582000													40	89					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272760	81272760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81272760C>T	ENST00000520547.2	+	1	404	c.355C>T	c.(355-357)Ctt>Ttt	p.L119F		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	119					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TGAGGGAGACCTTGGCAAGGA	0.547000													16	166					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11758700	11758700	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11758700G>A	ENST00000381486.2	+	22	3999	c.3699G>A	c.(3697-3699)gtG>gtA	p.V1233V	GREB1_ENST00000396123.1_Silent_p.V231V|GREB1_ENST00000234142.5_Silent_p.V1233V	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1233						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CCTCATCCGTGGCGCCCGCTG	0.672000													7	22					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156640282	156640282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156640282G>A	ENST00000368223.3	-	4	3830	c.3698C>T	c.(3697-3699)cCt>cTt	p.P1233L		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1233	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGAGGCCCAGGGGCATCTTC	0.637000													68	141					0	0	1	0	0
USP2	9099	broad.mit.edu	37	11	119229819	119229819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119229819G>A	ENST00000260187.2	-	6	1381	c.1087C>T	c.(1087-1089)Cgc>Tgc	p.R363C	USP2_ENST00000455332.2_Missense_Mutation_p.R120C|USP2_ENST00000525735.1_Missense_Mutation_p.R154C	NM_004205.4	NP_004196.4	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2	363					cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	24		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		AGAAGAAAGCGAAGGAACTCC	0.527000													38	21					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20480926	20480926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20480926G>A	ENST00000573854.1	+	4	595	c.481G>A	c.(481-483)Gat>Aat	p.D161N	ACSM2A_ENST00000575690.1_Missense_Mutation_p.D161N|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.D161N|ACSM2A_ENST00000536134.1_De_novo_Start_InFrame|ACSM2A_ENST00000424070.1_Missense_Mutation_p.D161N|ACSM2A_ENST00000417235.2_Missense_Mutation_p.D82N|ACSM2A_ENST00000396104.2_Missense_Mutation_p.D161N	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	161					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						TGTTGCTGGGGATGAAGTCAT	0.448000													41	139					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55107474	55107474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:55107474C>T	ENST00000474759.1	+	36	3038	c.2990C>T	c.(2989-2991)tCc>tTc	p.S997F	CACNA2D3_ENST00000415676.2_Missense_Mutation_p.S997F|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.S997F|CACNA2D3_ENST00000478261.1_Intron|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.S903F	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	997						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TCCAACAGGTCCTTTGTCATC	0.507000													18	47					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16925901	16925901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16925901G>A	ENST00000552788.1	+	18	4456	c.4456G>A	c.(4456-4458)Ggc>Agc	p.G1486S	NWD1_ENST00000524140.2_3'UTR|NWD1_ENST00000523826.1_Missense_Mutation_p.G1280S|NWD1_ENST00000379808.3_3'UTR|NWD1_ENST00000339803.6_Missense_Mutation_p.G1351S|NWD1_ENST00000549814.1_Missense_Mutation_p.G1444S			Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1486							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AACCACCAGTGGCTTCATTGC	0.488000													21	57					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14150715	14150715	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14150715G>A	ENST00000263379.2	+	4	652	c.527G>A	c.(526-528)tGg>tAg	p.W176*		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	176	Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						GAGGCGGCCTGGACCCTGGTG	0.587000													47	86					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39986644	39986644	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39986644C>T	ENST00000373257.3	+	17	2253	c.2162C>T	c.(2161-2163)tCt>tTt	p.S721F	LPIN3_ENST00000491528.1_3'UTR	NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	721	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				ATCCTTCTGTCTCCCAGCAGC	0.672000													21	84					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6012345	6012345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:6012345G>A	ENST00000259569.5	-	1	3273	c.3263C>T	c.(3262-3264)tCa>tTa	p.S1088L		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	1088					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCAAGTTGTGATACACATTC	0.353000													13	58					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45016647	45016647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:45016647G>A	ENST00000258787.7	-	2	255	c.119C>T	c.(118-120)aCc>aTc	p.T40I		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	40	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						ACCGATGTAGGTGTAGATGCG	0.617000													37	47					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287288	202287288	+	Silent	SNP	C	C	T	rs148517456	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202287288C>T	ENST00000367278.3	+	18	1946	c.1857C>T	c.(1855-1857)gcC>gcT	p.A619A	LGR6_ENST00000439764.2_Silent_p.A480A|LGR6_ENST00000255432.7_Silent_p.A567A	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	619						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						GCCTTCTAGCCTCAGTCGATG	0.627000													15	30					0	0	1	0	0
NUSAP1	51203	broad.mit.edu	37	15	41643234	41643234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41643234C>T	ENST00000260359.6	+	4	574	c.310C>T	c.(310-312)Cat>Tat	p.H104Y	NUSAP1_ENST00000558123.1_3'UTR|NUSAP1_ENST00000560177.1_Missense_Mutation_p.H118Y|NUSAP1_ENST00000450318.1_Missense_Mutation_p.H119Y|NUSAP1_ENST00000450592.2_Missense_Mutation_p.H96Y|NUSAP1_ENST00000560747.1_Missense_Mutation_p.H118Y|NUSAP1_ENST00000559596.1_Missense_Mutation_p.H119Y|NUSAP1_ENST00000414849.2_Missense_Mutation_p.H119Y	NM_001243142.1|NM_001243143.1|NM_016359.4|NM_018454.7	NP_001230071.1|NP_001230072.1|NP_057443.2|NP_060924.4	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	119					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)|ovary(1)|prostate(2)|urinary_tract(2)	13		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		ATTCCAGAATCATGAAAAGCA	0.378000													11	23					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328089	126328089	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126328089C>T	ENST00000394329.3	+	3	5375	c.5362C>T	c.(5362-5364)Cgc>Tgc	p.R1788C	FAT4_ENST00000335110.5_Missense_Mutation_p.R86C	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1788	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGATAGTTTTCGCATCGACCC	0.463000													50	92					0	0	1	0	0
MOCS2	4338	broad.mit.edu	37	5	52394456	52394456	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52394456C>A	ENST00000396954.3	-	7	1220	c.543G>T	c.(541-543)gaG>gaT	p.E181D	MOCS2_ENST00000361377.4_3'UTR|MOCS2_ENST00000450852.3_3'UTR|MOCS2_ENST00000582677.1_3'UTR|MOCS2_ENST00000584946.1_3'UTR|MOCS2_ENST00000508922.1_3'UTR|MOCS2_ENST00000510818.2_3'UTR	NM_004531.3	NP_004522.1	O96033	MOC2A_HUMAN	molybdenum cofactor synthesis 2	0					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex	nucleotide binding			endometrium(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(810;3.08e-05)|Breast(144;0.0848)				CCCAAAAGCACTCTTTGTTTC	0.279000													29	81					8.16721e-17	8.21313e-17	1	1	0
ADCY5	111	broad.mit.edu	37	3	123039618	123039618	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123039618C>T	ENST00000462833.1	-	9	3301	c.2088_splice	c.e9-1	p.G697_splice	ADCY5_ENST00000491190.1_Splice_Site_p.G330_splice|ADCY5_ENST00000309879.5_Splice_Site_p.G347_splice	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	697					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TCTTCAAAGCCCTagaagaga	0.473000													8	27					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2944669	2944669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2944669C>T	ENST00000520002.1	-	50	7982	c.7427G>A	c.(7426-7428)cGa>cAa	p.R2476Q	CSMD1_ENST00000542608.1_Missense_Mutation_p.R2475Q|CSMD1_ENST00000537824.1_Missense_Mutation_p.R2475Q|CSMD1_ENST00000602723.1_Missense_Mutation_p.R2476Q|CSMD1_ENST00000400186.3_Missense_Mutation_p.R2476Q|CSMD1_ENST00000602557.1_Missense_Mutation_p.R2476Q			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2476	Sushi 14.					integral to membrane		p.R2204P(1)|p.R2204Q(1)|p.R2475P(1)|p.R2475Q(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAGTGGGTTTCGTCTACAGGT	0.507000													12	42					0	0	1	0	0
S1PR5	53637	broad.mit.edu	37	19	10625613	10625613	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10625613G>A	ENST00000439028.3	-	2	200	c.75C>T	c.(73-75)ctC>ctT	p.L25L	S1PR5_ENST00000333430.4_Silent_p.L25L	NM_001166215.1	NP_001159687.1	Q9H228	S1PR5_HUMAN	sphingosine-1-phosphate receptor 5	25						integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	12						GCGCACCGCGGAGCTTGCCGG	0.692000													17	56					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149482623	149482623	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149482623G>A	ENST00000378016.2	+	0	3039							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCAGTGGGCGGTGCCAGGCAT	0.672000													4	8					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53345105	53345105	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53345105G>A	ENST00000595646.1	-	4	562	c.442C>T	c.(442-444)Ctg>Ttg	p.L148L	ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Silent_p.L95L|ZNF468_ENST00000396409.4_Silent_p.L95L|ZNF28_ENST00000594602.1_Intron			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		GGTTCAGGCAGATGCAAATGA	0.403000													30	309					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062075	9062075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9062075C>T	ENST00000397910.4	-	3	25574	c.25371G>A	c.(25369-25371)agG>agA	p.R8457R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8459	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGATGTTCCCCTAGAGGATA	0.512000													39	156					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402247	89402247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89402247C>T	ENST00000439576.2	+	12	6805	c.6431C>T	c.(6430-6432)tCc>tTc	p.S2144F	ACAN_ENST00000559004.1_Missense_Mutation_p.S2144F|ACAN_ENST00000561243.1_Missense_Mutation_p.S2144F|ACAN_ENST00000352105.7_Missense_Mutation_p.S2144F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2144					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTTGAGAGATCCTCTGGCCTA	0.572000													28	145					0	0	1	0	0
WHAMM	123720	broad.mit.edu	37	15	83499498	83499498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83499498C>T	ENST00000286760.4	+	9	1888	c.1789C>T	c.(1789-1791)Ccc>Tcc	p.P597S		NM_001080435.1	NP_001073904.1	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi membranes and microtubules	597						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding			endometrium(6)|large_intestine(5)|lung(1)|prostate(1)	13						TAGAGGTGTTCCCCTATCGGA	0.488000													26	75					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49052746	49052746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:49052746G>A	ENST00000226432.4	+	15	2084	c.1901G>A	c.(1900-1902)aGt>aAt	p.S634N	CWH43_ENST00000513409.1_Missense_Mutation_p.S607N	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	634					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						GCTGAACTGAGTGATTCAGAA	0.383000													34	70					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782677	54782677	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54782677G>A	ENST00000391748.1	-	6	1072	c.945C>T	c.(943-945)atC>atT	p.I315I	LILRB2_ENST00000434421.1_Silent_p.I199I|LILRB2_ENST00000391746.1_Silent_p.I315I|LILRB2_ENST00000314446.5_Silent_p.I315I|LILRB2_ENST00000391749.4_Silent_p.I315I	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	315	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGTGATCAGGATGTCCAGGG	0.652000													22	20					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406212	55406212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55406212C>T	ENST00000314612.2	+	1	379	c.379C>T	c.(379-381)Ccc>Tcc	p.P127S		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						CATTTGCAAGCCCCTGCACTA	0.418000													22	76					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132399036	132399036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:132399036C>T	ENST00000331898.7	-	3	1023	c.445G>A	c.(445-447)Gag>Aag	p.E149K	OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000541867.1_Missense_Mutation_p.E149K|OPCML_ENST00000524381.1_Missense_Mutation_p.E142K|OPCML_ENST00000374778.4_Missense_Mutation_p.E108K	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	149	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		CTGCTTCCCTCATTCACAGTG	0.463000													23	60					0	0	1	0	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216779	26216779	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26216779C>T	ENST00000244601.3	-	1	93	c.93G>A	c.(91-93)aaG>aaA	p.K31K		NM_003518.3	NP_003509.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	31					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	8		all_hematologic(11;0.196)				TACGACTGCGCTTGCGCTTCT	0.527000													58	230					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51675865	51675865	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51675865C>T	ENST00000409535.1	+	14	2457	c.2332C>T	c.(2332-2334)Cga>Tga	p.R778*	RAD54L2_ENST00000296477.3_Nonsense_Mutation_p.R472*	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	778	Helicase C-terminal.					nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		GAAGTGGGTTCGAAACATCAG	0.493000													9	8					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599818	136599818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136599818C>T	ENST00000531224.1	-	4	453	c.201G>A	c.(199-201)atG>atA	p.M67I	BCLAF1_ENST00000392348.2_Missense_Mutation_p.M65I|BCLAF1_ENST00000530767.1_Missense_Mutation_p.M67I|BCLAF1_ENST00000527759.1_Missense_Mutation_p.M65I|BCLAF1_ENST00000527536.1_Missense_Mutation_p.M67I|BCLAF1_ENST00000353331.4_Missense_Mutation_p.M65I	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	67					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAGGTCGTCTCATTCCTCTAT	0.428000													9	87					0	0	1	0	0
CYP2F1	1572	broad.mit.edu	37	19	41627980	41627980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41627980C>T	ENST00000331105.2	+	6	836	c.764C>T	c.(763-765)tCg>tTg	p.S255L		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	255					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						CACCAGGCCTCGCTAGACCCC	0.587000													4	58					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70189923	70189923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70189923C>T	ENST00000253925.7	+	15	2071	c.1856C>T	c.(1855-1857)cCc>cTc	p.P619L	PPFIA1_ENST00000389547.3_Missense_Mutation_p.P619L|AP000487.6_ENST00000528607.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	619					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CTGCTATCGCCCAGCGGGCAG	0.552000													7	42					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68810254	68810254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68810254C>T	ENST00000508048.1	-	3	267	c.232G>A	c.(232-234)Gag>Aag	p.E78K	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.E79K|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.E79K			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	79	SEA.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TCGGTCGTCTCTCGTAAGTCC	0.338000													45	111					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528284	20528284	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20528284C>T	ENST00000315683.1	+	1	81	c.81C>T	c.(79-81)ttC>ttT	p.F27F		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F27L(1)		central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAATTTTCTTCTTTGTGACAT	0.383000													91	219					0	0	1	0	0
SNORD113-6	767566	broad.mit.edu	37	14	101405917	101405917	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101405917G>A	ENST00000363345.2	+	0	25					NR_003234.1																						ATATCATGGGGTTTCTGAAAC	0.358000													19	42					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96706530	96706530	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:96706530G>A	ENST00000389672.5	+	3	845	c.807G>A	c.(805-807)gaG>gaA	p.E269E	EPHA6_ENST00000470610.2_Silent_p.E269E|EPHA6_ENST00000542517.1_Silent_p.E175E	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	174						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AAATTCGTGAGGTGGGGCCTA	0.448000													52	283					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128177561	128177561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128177561G>A	ENST00000453608.2	+	2	114	c.106G>A	c.(106-108)Gga>Aga	p.G36R	PROC_ENST00000422777.3_Missense_Mutation_p.G15R|PROC_ENST00000234071.3_Missense_Mutation_p.G15R|PROC_ENST00000409048.1_Missense_Mutation_p.G15R			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	15					blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	GGCCACCTGGGGAATTTCCGG	0.642000													18	50					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105349891	105349891	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105349891G>A	ENST00000369780.4	+	6	1896	c.1486_splice	c.e6-1	p.G496_splice	SH3PXD2A_ENST00000427662.2_Intron|NEURL_ENST00000369777.2_Splice_Site_p.G479_splice	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		496					nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TTGTCCTCAGGGACAGCCCCC	0.632000													40	149					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150906174	150906174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:150906174G>A	ENST00000474524.1	+	12	1698	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K	MED12L_ENST00000422248.2_Missense_Mutation_p.E554K|MED12L_ENST00000309237.4_Missense_Mutation_p.E554K|MED12L_ENST00000273432.4_Missense_Mutation_p.E414K	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	554					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGATGAGAAGGAGTCTATTTC	0.353000													35	76					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770253	53770253	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53770253G>A	ENST00000311170.4	-	1	719	c.666C>T	c.(664-666)tcC>tcT	p.S222S		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	222					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		AGGCTCTGGGGGAGAGATTGC	0.537000										HNSCC(26;0.072)			8	17					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6505811	6505811	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6505811A>T	ENST00000377828.1	+	7	1448	c.1280A>T	c.(1279-1281)aAg>aTg	p.K427M	RP1-202O8.2_ENST00000419034.1_RNA	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	427					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		ACGATTGGGAAGcccacaccc	0.687000													7	11					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135413078	135413078	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135413078G>A	ENST00000343036.2	+	5	771	c.723G>A	c.(721-723)ctG>ctA	p.L241L	C9orf171_ENST00000393216.2_Silent_p.L205L	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	241										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						CCATCAAACTGGAGAAGAAGC	0.557000													28	77					0	0	1	0	0
AJUBA	84962	broad.mit.edu	37	14	23443310	23443310	+	Silent	SNP	G	G	A	rs146599877	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23443310G>A	ENST00000262713.2	-	7	1812	c.1437C>T	c.(1435-1437)atC>atT	p.I479I	RP11-298I3.5_ENST00000555074.1_Intron|AJUBA_ENST00000361265.4_Silent_p.I479I|AJUBA_ENST00000397388.3_Silent_p.I62I	NM_032876.4	NP_116265.1	Q96IF1	JUB_HUMAN	ajuba LIM protein	479	LIM zinc-binding 3.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding										TCACCCTCACGATGTCCTCAC	0.537000											OREG0022591	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	57	143					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53678703	53678703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53678703G>A	ENST00000396424.3	-	3	226	c.137C>T	c.(136-138)tCc>tTc	p.S46F	ZNF665_ENST00000600412.1_Intron	NM_024733.3	NP_079009.3	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		CTCACCCAGGGAGACCAGGTT	0.483000													56	145					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126771152	126771152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:126771152C>T	ENST00000274473.6	+	17	2342	c.2075C>T	c.(2074-2076)cCc>cTc	p.P692L	MEGF10_ENST00000503335.2_Missense_Mutation_p.P692L	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	692	EGF-like 12.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CAGTGTTACCCCGGTTGGATT	0.418000													8	52					0	0	1	0	0
DOK2	9046	broad.mit.edu	37	8	21769936	21769936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:21769936G>A	ENST00000276420.4	-	2	407	c.149C>T	c.(148-150)cCt>cTt	p.P50L	DOK2_ENST00000544659.1_5'UTR	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	50	PH.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		ACACCGACGAGGCTTCTCCGG	0.711000													4	10					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75107456	75107456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:75107456C>T	ENST00000290573.2	+	10	1930	c.1330C>T	c.(1330-1332)Cgc>Tgc	p.R444C	HK2_ENST00000409174.1_Missense_Mutation_p.R416C	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	444	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						CCGCTTCCTCCGCTCCGAGGA	0.617000													113	228					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771318	143771318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143771318G>A	ENST00000408898.2	+	1	44	c.6G>A	c.(4-6)ggG>ggA	p.G2G		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					GGGAAATGGGGGGAAATCAGA	0.443000													25	98					0	0	1	0	0
FAM118A	55007	broad.mit.edu	37	22	45723824	45723824	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45723824C>T	ENST00000216214.3	+	5	1236	c.402C>T	c.(400-402)atC>atT	p.I134I	FAM118A_ENST00000405673.1_Silent_p.I134I|FAM118A_ENST00000441876.2_Silent_p.I134I	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	134						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TGCAGTCGATCCTCAGCCTGA	0.617000													11	41					0	0	1	0	0
CTRC	11330	broad.mit.edu	37	1	15766993	15766993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15766993C>T	ENST00000375949.4	+	3	163	c.137C>T	c.(136-138)tCc>tTc	p.S46F	CTRC_ENST00000375943.2_Intron|CTRC_ENST00000483406.1_3'UTR	NM_007272.2	NP_009203.2	Q99895	CTRC_HUMAN	chymotrypsin C (caldecrin)	46	Peptidase S1.				proteolysis		serine-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)	13		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTGCAGATCTCCCTCCAGTAC	0.617000													16	21					0	0	1	0	0
NIPAL1	152519	broad.mit.edu	37	4	48035011	48035011	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48035011G>A	ENST00000295461.5	+	4	438	c.370_splice	c.e4-1	p.M124_splice	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	124						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						GCTTTCTAGTGGGAGCAGGAG	0.428000													12	44					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131118023	131118023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131118023C>T	ENST00000300456.3	+	12	1839	c.1722C>T	c.(1720-1722)ccC>ccT	p.P574P	SLC27A4_ENST00000372870.1_Silent_p.P168P	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	574					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						AGGAACTGCCCCTGTATGCGC	0.652000													21	74					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152328286	152328286	+	Missense_Mutation	SNP	C	C	T	rs145112487		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152328286C>T	ENST00000388718.5	-	3	2048	c.1976G>A	c.(1975-1977)gGa>gAa	p.G659E	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	659	Ser-rich.						calcium ion binding|structural molecule activity	p.G659E(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGCCTGATCCATATTGGCC	0.493000													142	377					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594905	179594905	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179594905G>A	ENST00000589042.1	-	62	18446	c.18222C>T	c.(18220-18222)gcC>gcT	p.A6074A	TTN_ENST00000342992.6_Silent_p.A4830A|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.A5757A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5757	Ig-like 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGTAGCTTTGGCTGCAAAGA	0.448000													5	41					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64212957	64212957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64212957C>T	ENST00000205948.6	-	6	770	c.733G>A	c.(733-735)Gaa>Aaa	p.E245K		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	245	Sushi 4.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			CATTCTATTTCTTCCGGGCCA	0.418000													49	111					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643428	37643428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37643428C>T	ENST00000356958.4	-	5	1631	c.1373G>A	c.(1372-1374)cGa>cAa	p.R458Q	ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000392157.2_Missense_Mutation_p.R403Q|ZNF585A_ENST00000355533.2_Intron|ZNF585A_ENST00000292841.5_Missense_Mutation_p.R403Q			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	458					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding	p.R403Q(1)		breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTGTGAATTCGTTTATGAAC	0.398000													52	161					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18524229	18524229	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18524229C>T	ENST00000433979.1	+	12	1857	c.1741C>T	c.(1741-1743)Cca>Tca	p.P581S	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.P581S|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.P622S	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	581					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GACTTGTCTTCCACTGTTTCC	0.358000													9	32					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23874889	23874889	+	Missense_Mutation	SNP	C	C	T	rs140596256	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23874889C>T	ENST00000405093.3	-	4	362	c.292G>A	c.(292-294)Gag>Aag	p.E98K	MYH6_ENST00000356287.3_Missense_Mutation_p.E98K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	98	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ACCGCGGGCTCGTGCAGGAAG	0.592000													18	71					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138566163	138566163	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138566163G>A	ENST00000440172.1	-	11	4248	c.4200C>T	c.(4198-4200)atC>atT	p.I1400I	KIAA1549_ENST00000422774.1_Silent_p.I1400I|KIAA1549_ENST00000242365.4_Silent_p.I1350I	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1400						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TCTTGGAAGGGATCTTTGACT	0.473000			O	BRAF	pilocytic astrocytoma								32	71					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3087637	3087637	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3087637G>A	ENST00000520002.1	-	28	4828	c.4273C>T	c.(4273-4275)Caa>Taa	p.Q1425*	CSMD1_ENST00000542608.1_Nonsense_Mutation_p.Q1424*|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000539096.1_Nonsense_Mutation_p.Q1424*|CSMD1_ENST00000537824.1_Nonsense_Mutation_p.Q1424*|CSMD1_ENST00000602723.1_Nonsense_Mutation_p.Q1425*|CSMD1_ENST00000400186.3_Nonsense_Mutation_p.Q1425*|CSMD1_ENST00000602557.1_Nonsense_Mutation_p.Q1425*			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1425	Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTTGTCCTTGGAGCTGATAG	0.502000													12	31					0	0	1	0	0
SRSF2	6427	broad.mit.edu	37	17	74733199	74733199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74733199G>A	ENST00000392485.2	-	1	216	c.44C>T	c.(43-45)tCc>tTc	p.S15F	MFSD11_ENST00000591864.1_Intron|SRSF2_ENST00000359995.5_Missense_Mutation_p.S15F|MFSD11_ENST00000586622.1_Intron|SRSF2_ENST00000508921.3_Missense_Mutation_p.S15F|RP11-318A15.7_ENST00000587459.1_Intron|MFSD11_ENST00000588460.1_5'UTR	NM_003016.4	NP_003007.2	Q01130	SRSF2_HUMAN	serine/arginine-rich splicing factor 2	15	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity			haematopoietic_and_lymphoid_tissue(320)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)	329						CACCTTGAGGGAGGTCATACC	0.687000			Mis		"""MDS, CLL"""								3	7					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6525594	6525594	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6525594G>A	ENST00000377782.3	-	2	133	c.66C>T	c.(64-66)gcC>gcT	p.A22A	TNFRSF25_ENST00000461703.2_5'UTR|TNFRSF25_ENST00000348333.3_Silent_p.A22A|TNFRSF25_ENST00000356876.3_Silent_p.A22A|TNFRSF25_ENST00000351748.3_Silent_p.A22A|TNFRSF25_ENST00000351959.5_Silent_p.A22A	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	22					apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGGGCCCGGGCCCCCAGCA	0.652000													14	23					0	0	1	0	0
MCHR1	2847	broad.mit.edu	37	22	41075531	41075531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41075531G>A	ENST00000249016.4	+	1	778	c.82G>A	c.(82-84)Gac>Aac	p.D28N	MCHR1_ENST00000381433.2_Missense_Mutation_p.D28N|MCHR1_ENST00000498400.1_Intron	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	28			D -> V.		elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						TACGGAGGAAGACCCCCTTCC	0.652000													16	35					0	0	1	0	0
FNDC9	408263	broad.mit.edu	37	5	156770210	156770210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156770210G>A	ENST00000312349.4	-	2	522	c.335C>T	c.(334-336)tCc>tTc	p.S112F	CYFIP2_ENST00000541131.1_Intron|CYFIP2_ENST00000318218.6_Intron|CYFIP2_ENST00000347377.6_Intron|CYFIP2_ENST00000442283.2_Intron|CYFIP2_ENST00000521420.1_Intron|CYFIP2_ENST00000522463.1_Intron|CYFIP2_ENST00000377576.3_Intron|CYFIP2_ENST00000435847.2_Intron	NM_001001343.3	NP_001001343.2	Q8TBE3	FNDC9_HUMAN	fibronectin type III domain containing 9	112						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	9						CACCCAAAGGGAGATCTGGGG	0.587000											OREG0016977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	62					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49726071	49726071	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49726071G>A	ENST00000449682.2	-	1	415	c.54C>T	c.(52-54)ctC>ctT	p.L18L	MST1_ENST00000545762.1_Silent_p.L4L|MST1_ENST00000383728.3_5'UTR|MST1_ENST00000494828.2_5'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	4					proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCAGGAGTGGGAGCCACCCCA	0.612000													8	15					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108389018	108389018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:108389018G>A	ENST00000263054.6	-	19	2611	c.2604C>T	c.(2602-2604)acC>acT	p.T868T	SORCS1_ENST00000344440.6_Silent_p.T868T|SORCS1_ENST00000369698.1_Silent_p.T403T	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	868	PKD.					integral to membrane	neuropeptide receptor activity|protein binding	p.T868T(1)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCACCTGCACGGTCACACGGA	0.458000													22	28					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981878	61981878	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61981878G>A	ENST00000370263.4	-	5	1106	c.885C>T	c.(883-885)atC>atT	p.I295I	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	295					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TGGACGGGATGATCTCGGTGA	0.577000													27	62					0	0	1	0	0
RHBG	57127	broad.mit.edu	37	1	156351641	156351641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156351641G>A	ENST00000400992.2	+	6	1157	c.789G>A	c.(787-789)ggG>ggA	p.G263G	RHBG_ENST00000368246.2_Silent_p.G295G|RHBG_ENST00000368249.1_Silent_p.G295G|RHBG_ENST00000537040.1_Silent_p.G133G|RHBG_ENST00000255013.3_Silent_p.G226G|RHBG_ENST00000451864.2_Intron			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	295					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					TTGTGGTGGGGACCTCAAGTG	0.557000													24	64					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64974679	64974679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:64974679G>A	ENST00000399262.2	-	8	1466	c.1248C>T	c.(1246-1248)ccC>ccT	p.P416P	JMJD1C_ENST00000402544.1_Silent_p.P197P|JMJD1C_ENST00000542921.1_Silent_p.P234P|JMJD1C_ENST00000399251.1_Silent_p.P197P	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	416					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					CATTATTATGGGGTTTTCCTT	0.348000													18	57					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979755	12979755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12979755C>T	ENST00000361079.2	+	4	1030	c.947C>T	c.(946-948)cCg>cTg	p.P316L						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCTTGGTGCCCGAGCATCCGT	0.572000													49	101					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92523361	92523361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92523361G>A	ENST00000298047.6	+	7	4605	c.4588G>A	c.(4588-4590)Gac>Aac	p.D1530N	FAT3_ENST00000409404.2_Missense_Mutation_p.D1530N|FAT3_ENST00000525166.1_Missense_Mutation_p.D1380N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1530	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAGGCCCAGGACAAGCACAT	0.483000										TCGA Ovarian(4;0.039)			42	119					0	0	1	0	0
UPK1B	7348	broad.mit.edu	37	3	118909934	118909934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:118909934G>A	ENST00000264234.3	+	5	600	c.451G>A	c.(451-453)Gac>Aac	p.D151N	UPK1B_ENST00000460625.1_Missense_Mutation_p.D143N|UPK1B_ENST00000497685.1_Missense_Mutation_p.D71N	NM_006952.3	NP_008883.2	O75841	UPK1B_HUMAN	uroplakin 1B	151					epithelial cell differentiation	integral to membrane	structural molecule activity			breast(1)|endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	14				GBM - Glioblastoma multiforme(114;0.222)		CAAAACCTGGGACAGGCTCAT	0.493000													79	177					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98144361	98144361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98144361C>T	ENST00000357947.3	-	16	2402	c.2177G>A	c.(2176-2178)aGg>aAg	p.R726K		NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	726	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GAAGTGGGCCCTGAAGCCGCG	0.627000													43	102					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47398567	47398567	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47398567C>T	ENST00000285039.7	-	27	3872	c.3573G>A	c.(3571-3573)ccG>ccA	p.P1191P	MYO5B_ENST00000587895.1_5'UTR|MYO5B_ENST00000324581.6_Silent_p.P332P	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1191					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.P1191P(1)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GATCTGCATTCGGGTCCAAAT	0.507000													27	468					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402193	89402193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89402193C>T	ENST00000439576.2	+	12	6751	c.6377C>T	c.(6376-6378)tCc>tTc	p.S2126F	ACAN_ENST00000559004.1_Missense_Mutation_p.S2126F|ACAN_ENST00000561243.1_Missense_Mutation_p.S2126F|ACAN_ENST00000352105.7_Missense_Mutation_p.S2126F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2126					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GATTCTGGGTCCCCTGATCTG	0.552000													29	105					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73070485	73070485	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73070485C>T	ENST00000429829.1	-	0	2103					NR_001564.2																						GGAGCACTGCCCATGGCAACA	0.652000													2	0					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102712909	102712909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102712909C>T	ENST00000299855.5	-	4	857	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	201					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	GTCCATTGTTCATCATCATCA	0.393000													29	60					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420437	55420437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55420437C>T	ENST00000242994.3	+	2	592	c.214C>T	c.(214-216)Ccc>Tcc	p.P72S		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	72					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						GAGAAGGGGTCCCAAGAAAAA	0.483000													10	39					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6203924	6203924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6203924C>T	ENST00000262450.3	-	13	2101	c.2002G>A	c.(2002-2004)Gac>Aac	p.D668N	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	668					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGCTTGTCGTCCCTCAGCTTC	0.642000													37	82					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424653	56424653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56424653C>T	ENST00000588751.1	-	5	554	c.530G>A	c.(529-531)aGa>aAa	p.R177K	NLRP13_ENST00000342929.3_Missense_Mutation_p.R177K			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	177							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTATTTTCTTCTGTGGTCTAG	0.413000													52	108					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15702076	15702076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15702076C>T	ENST00000281171.4	+	14	2683	c.2353C>T	c.(2353-2355)Cct>Tct	p.P785S	PTPRO_ENST00000542557.1_5'UTR|PTPRO_ENST00000442921.2_5'UTR|PTPRO_ENST00000544244.1_5'UTR|PTPRO_ENST00000348962.2_Missense_Mutation_p.P785S|PTPRO_ENST00000445537.2_5'UTR	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	785	Fibronectin type-III 8.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				CAGCCTTCTTCCTGCCACTGC	0.428000													80	173					0	0	1	0	0
CWC22	57703	broad.mit.edu	37	2	180846611	180846611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:180846611G>A	ENST00000410053.3	-	5	619	c.320C>T	c.(319-321)tCc>tTc	p.S107F	CWC22_ENST00000295749.6_Missense_Mutation_p.S107F	NM_020943.2	NP_065994.1	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	107						catalytic step 2 spliceosome	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(8)|stomach(1)	30						CTGAGCAGAGGAACTCTGAGT	0.473000													8	18					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55838477	55838477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:55838477G>A	ENST00000302000.6	-	3	1098	c.1004C>T	c.(1003-1005)tCg>tTg	p.S335L	PYGO1_ENST00000563719.1_Missense_Mutation_p.S335L	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	335					Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		GTCAGAAGACGAATGGCCATG	0.473000													96	213					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226923820	226923820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226923820G>A	ENST00000429204.1	-	2	1667	c.1340C>T	c.(1339-1341)tCc>tTc	p.S447F	ITPKB_ENST00000272117.3_Missense_Mutation_p.S447F|ITPKB_ENST00000366784.1_Missense_Mutation_p.S447F	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	447							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				CAGCGTTGGGGACCCTCCCTC	0.706000													27	70					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32157053	32157053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32157053G>A	ENST00000373672.3	-	19	1879	c.1363C>T	c.(1363-1365)Cct>Tct	p.P455S	COL16A1_ENST00000373668.3_Missense_Mutation_p.P455S|COL16A1_ENST00000271069.6_Missense_Mutation_p.P455S	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	455	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGGGTCCAGGGAGGCCGGGG	0.667000													4	47					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107125991	107125991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107125991G>A	ENST00000392842.1	+	14	1849	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K	RFX4_ENST00000229387.5_Missense_Mutation_p.E385K|RP11-144F15.1_ENST00000551505.1_Intron|RP11-482D24.3_ENST00000552415.1_RNA|RFX4_ENST00000357881.4_Missense_Mutation_p.E488K	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	479	Necessary for dimerization.				transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GCGGGCCAATGAGCTCATGCG	0.448000													31	118					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118753046	118753046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:118753046G>A	ENST00000376300.2	-	6	632	c.495C>T	c.(493-495)gcC>gcT	p.A165A	CCDC93_ENST00000460781.1_5'UTR|CCDC93_ENST00000319432.5_Silent_p.A165A	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	165										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						CTGTCTTGATGGCCTTTTCTT	0.433000													37	99					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7655151	7655151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7655151C>T	ENST00000359156.4	-	2	258	c.56G>A	c.(55-57)aGa>aAa	p.R19K	CD163_ENST00000432237.2_Missense_Mutation_p.R19K|CD163_ENST00000396620.3_Missense_Mutation_p.R19K|CD163_ENST00000541972.1_Missense_Mutation_p.R7K	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	19					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						gacaaaatgtcttctgaagtc	0.383000													3	9					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10415830	10415830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10415830C>T	ENST00000226207.5	-	12	1136	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	348	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GACACTCTTTCATCTGAAGTA	0.428000													23	72					0	0	1	0	0
SAV1	60485	broad.mit.edu	37	14	51132005	51132005	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51132005G>A	ENST00000324679.4	-	2	790	c.427C>T	c.(427-429)Cag>Tag	p.Q143*		NM_021818.3	NP_068590.1	Q9H4B6	SAV1_HUMAN	salvador homolog 1 (Drosophila)	143					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)|kidney(2)|lung(2)|prostate(1)	6	all_epithelial(31;0.000611)|Breast(41;0.0333)					CGCTTTCTCTGACCATCAAAA	0.403000													31	67					0	0	1	0	0
HIC1	3090	broad.mit.edu	37	17	1961664	1961664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:1961664G>A	ENST00000399849.2	+	2	1840	c.1680G>A	c.(1678-1680)acG>acA	p.T560T	HIC1_ENST00000322941.3_Silent_p.T579T	NM_006497.3	NP_006488.2	Q14526	HIC1_HUMAN	hypermethylated in cancer 1	579					multicellular organismal development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|lung(1)|prostate(1)	3				READ - Rectum adenocarcinoma(1115;0.236)		ACCGCCTCACGGAGCACATGC	0.657000													8	10					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121503	38121503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38121503C>T	ENST00000406386.3	+	7	3195	c.2940C>T	c.(2938-2940)tcC>tcT	p.S980S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	980					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CCTCTTCCTCCCATAACCCAG	0.642000													82	232					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61848091	61848091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61848091C>T	ENST00000280772.1	-	29	3545	c.3354G>A	c.(3352-3354)ggG>ggA	p.G1118G	ANK3_ENST00000503366.1_Silent_p.G1119G|ANK3_ENST00000373827.2_Silent_p.G1112G|ANK3_ENST00000355288.2_Silent_p.G252G	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1118					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TACGCTTTTTCCCTAACTCTT	0.393000													9	98					0	0	1	0	0
OR52M1	119772	broad.mit.edu	37	11	4567312	4567312	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4567312C>T	ENST00000360213.1	+	1	892	c.892C>T	c.(892-894)Cgc>Tgc	p.R298C		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTATGCTGTTCGCACCAAGCA	0.448000													32	53					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80752498	80752498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80752498G>A	ENST00000458043.2	+	50	6148	c.6142G>A	c.(6142-6144)Gat>Aat	p.D2048N	OTOGL_ENST00000547103.1_Missense_Mutation_p.D2036N|OTOGL_ENST00000546620.1_Missense_Mutation_p.D67N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CTGTGCAGAAGATATGAATCT	0.313000													10	44					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474453	140474453	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140474453C>T	ENST00000194155.4	+	1	227	c.79C>T	c.(79-81)Cag>Tag	p.Q27*		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		27					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCATAGCTCAGGCTAGTTG	0.522000													27	58					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96495170	96495170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96495170C>T	ENST00000285979.6	+	9	1641	c.1442C>T	c.(1441-1443)cCc>cTc	p.P481L	CYP2C18_ENST00000339022.5_Missense_Mutation_p.P422L|CYP2C19_ENST00000464755.1_Intron	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		CGTGTGCCACCCTTGTACCAG	0.493000													23	185					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125289062	125289062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125289062C>T	ENST00000304880.2	-	1	510	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						TGAGCAATTTCCCCAGTCACA	0.502000													9	35					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87683257	87683257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87683257C>T	ENST00000320005.5	-	4	455	c.408G>A	c.(406-408)gtG>gtA	p.V136V		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	136					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						GCATTCTTTTCACCAGGTTGT	0.468000													80	259					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286164	48286164	+	Missense_Mutation	SNP	C	C	T	rs143647867	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48286164C>T	ENST00000320048.1	+	1	752	c.752C>T	c.(751-753)cCt>cTt	p.P251L		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						TTCTTCATACCTTGCTCCTTG	0.498000													20	139					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815940	43815940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43815940G>A	ENST00000382031.1	+	5	3014	c.2983G>A	c.(2983-2985)Gat>Aat	p.D995N	MAP1A_ENST00000300231.5_Missense_Mutation_p.D757N|MAP1A_ENST00000399453.1_Missense_Mutation_p.D757N			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	757						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGAGATCCATGATGAGCCGGA	0.562000													10	28					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17531255	17531255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17531255G>A	ENST00000005226.7	-	18	1660	c.1661C>T	c.(1660-1662)cCc>cTc	p.P554L	USH1C_ENST00000527720.1_Intron|USH1C_ENST00000529563.1_Intron|USH1C_ENST00000527020.1_Intron|USH1C_ENST00000318024.4_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	0					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						AGTCTTGGGGGGATAGTAGAA	0.627000													6	20					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43507420	43507420	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43507420G>A	ENST00000300215.3	-	3	850	c.393C>T	c.(391-393)tcC>tcT	p.S131S	EPB42_ENST00000540029.1_Intron|EPB42_ENST00000441366.2_Silent_p.S101S			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	101					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		AGATGGTCCAGGACTGGGCAT	0.567000													31	76					0	0	1	0	0
VPS54	51542	broad.mit.edu	37	2	64139739	64139739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:64139739G>A	ENST00000354504.3	-	16	2609	c.2020C>T	c.(2020-2022)Cat>Tat	p.H674Y	VPS54_ENST00000409558.3_Missense_Mutation_p.H815Y|VPS54_ENST00000272322.4_Missense_Mutation_p.H827Y			Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	827					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						GCTTCAAAATGAGCCCGGATC	0.358000													9	101					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21548263	21548263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21548263G>A	ENST00000415912.2	-	18	2190	c.2065C>T	c.(2065-2067)Ctc>Ttc	p.L689F	ECE1_ENST00000374893.6_Missense_Mutation_p.L705F|ECE1_ENST00000436918.2_Intron|ECE1_ENST00000264205.6_Missense_Mutation_p.L702F|ECE1_ENST00000357071.4_Missense_Mutation_p.L693F	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	705					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		AGGAAGAAGAGCTGGTTATTG	0.532000													84	231					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711233	41711233	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41711233C>T	ENST00000400454.1	-	7	1797	c.1320G>A	c.(1318-1320)tgG>tgA	p.W440*		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	440	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CGTCCAGGGTCCACGTGATCG	0.537000													15	36					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49726605	49726605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:49726605G>A	ENST00000451037.2	-	6	1512	c.572C>T	c.(571-573)tCa>tTa	p.S191L	CA10_ENST00000570565.1_Missense_Mutation_p.S116L|CA10_ENST00000571918.1_5'UTR|CA10_ENST00000442502.2_Missense_Mutation_p.S191L|CA10_ENST00000285273.4_Missense_Mutation_p.S191L|CA10_ENST00000340813.6_Missense_Mutation_p.S197L	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	191					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGGGTTTGATGAATCAGAAAC	0.358000													26	60					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100126096	100126096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100126096C>T	ENST00000394899.2	-	8	1182	c.1089G>A	c.(1087-1089)atG>atA	p.M363I	ADH6_ENST00000394897.1_3'UTR|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000237653.7_Missense_Mutation_p.M363I|ADH6_ENST00000407820.2_Missense_Mutation_p.M154I|RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA	NM_001102470.1	NP_001095940.1	P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	363					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TTCCAGTTTTCATTAATTCAA	0.373000													31	56					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735244	13735244	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13735244A>G	ENST00000265104.4	-	68	11861	c.11757T>C	c.(11755-11757)atT>atC	p.I3919I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3919					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATTGACCTTTAATAAGAGTGA	0.413000									Kartagener syndrome				18	47					0	0	1	0	0
WDR93	56964	broad.mit.edu	37	15	90276307	90276307	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90276307C>T	ENST00000268130.7	+	13	1502	c.1401C>T	c.(1399-1401)ttC>ttT	p.F467F	WDR93_ENST00000560294.1_Intron|WDR93_ENST00000444934.2_Silent_p.F184F	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	467					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			TAAAATATTTCTCGGTCCACA	0.483000													15	207					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38950520	38950520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38950520C>T	ENST00000302328.3	-	9	1465	c.1267G>A	c.(1267-1269)Gaa>Aaa	p.E423K	SCN11A_ENST00000456224.3_Missense_Mutation_p.E423K|SCN11A_ENST00000444237.2_Missense_Mutation_p.E423K|SCN11A_ENST00000450244.1_Missense_Mutation_p.E423K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	423					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGCTGGGCTTCCTGAAACATC	0.512000													60	174					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582563	82582563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82582563G>A	ENST00000423517.2	-	5	8043	c.7706C>T	c.(7705-7707)tCa>tTa	p.S2569L	PCLO_ENST00000333891.8_Missense_Mutation_p.S2569L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2500					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AAATCTTGGTGAAGACTTGTT	0.403000													48	131					0	0	1	0	0
ADRA2B	151	broad.mit.edu	37	2	96780804	96780804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96780804C>T	ENST00000409345.3	-	1	1180	c.1085G>A	c.(1084-1086)cGg>cAg	p.R362Q		NM_000682.5	NP_000673.2	P18089	ADA2B_HUMAN	adrenoceptor alpha 2B	365				QL -> HV (in Ref. 1 and 2).	activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GCGCTTCTCCCGGGTCAGCTG	0.657000													6	32					0	0	1	0	0
SLAMF7	57823	broad.mit.edu	37	1	160719870	160719870	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160719870G>A	ENST00000368043.3	+	3	673	c.636G>A	c.(634-636)agG>agA	p.R212R	SLAMF7_ENST00000441662.2_Intron|SLAMF7_ENST00000444090.2_Intron|SLAMF7_ENST00000368042.3_Silent_p.R105R|SLAMF7_ENST00000359331.4_Silent_p.R212R|SLAMF7_ENST00000458602.2_Silent_p.R105R|SLAMF7_ENST00000458104.2_Silent_p.R105R	NM_021181.3	NP_067004.3	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	212					cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TCCTTGCCAGGAAGCTCTGTG	0.557000													30	82					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121708823	121708823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:121708823C>T	ENST00000452319.1	+	4	319	c.259C>T	c.(259-261)Cct>Tct	p.P87S	GLI2_ENST00000361492.4_Missense_Mutation_p.P87S|GLI2_ENST00000314490.11_5'UTR|GLI2_ENST00000435313.2_3'UTR			P10070	GLI2_HUMAN	GLI family zinc finger 2	87					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CTGCAGGCCCCCTGCCCTCAG	0.632000													36	236					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39331902	39331902	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39331902C>T	ENST00000263408.4	-	5	586	c.491G>A	c.(490-492)gGg>gAg	p.G164E	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	164	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GGGATCCATCCCTAAAATGTT	0.458000													12	165					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95263154	95263154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95263154C>T	ENST00000344604.5	-	9	1935	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	ECM2_ENST00000444490.2_Missense_Mutation_p.D574N|CENPP_ENST00000375587.3_Intron	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	596					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						TCCATGCCATCATCAGCAAGT	0.443000													25	94					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171766709	171766709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:171766709G>A	ENST00000311601.5	-	13	1570	c.1400C>T	c.(1399-1401)tCc>tTc	p.S467F	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	467					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGGGGCCGGGAGGGGCCCGT	0.642000													15	39					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139909534	139909534	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139909534G>A	ENST00000265662.5	-	25	3860	c.3713C>T	c.(3712-3714)tCc>tTc	p.S1238F	ABCA2_ENST00000371605.3_Missense_Mutation_p.S1237F|ABCA2_ENST00000341511.6_Missense_Mutation_p.S1238F			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1237					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGGGGGGCTGGATGCCAGCCC	0.642000													16	31					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159707595	159707595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:159707595G>A	ENST00000393977.3	-	3	502	c.217C>T	c.(217-219)Cgc>Tgc	p.R73C	CCNJL_ENST00000257536.7_Missense_Mutation_p.R73C|CCNJL_ENST00000519673.1_Missense_Mutation_p.R73C|CCNJL_ENST00000377503.2_5'UTR|CCNJL_ENST00000541762.1_Missense_Mutation_p.R72C|CCNJL_ENST00000505287.2_Missense_Mutation_p.R118C	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	73	Cyclin N-terminal.					nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACGTTGTAGCGATCCATGAAG	0.617000													17	73					0	0	1	0	0
PAFAH2	5051	broad.mit.edu	37	1	26311004	26311004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26311004G>A	ENST00000374282.3	-	5	536	c.357C>T	c.(355-357)gcC>gcT	p.A119A	PAFAH2_ENST00000493892.1_5'UTR|PAFAH2_ENST00000374284.1_Silent_p.A119A	NM_000437.3	NP_000428.2	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2, 40kDa	119					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			NS(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|urinary_tract(1)	9		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		CCATGCAGAAGGCTGAATACA	0.527000													11	34					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94693326	94693326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94693326G>A	ENST00000282020.4	+	16	2959	c.2701G>A	c.(2701-2703)Gat>Aat	p.D901N	GRID2_ENST00000510992.1_Missense_Mutation_p.D806N	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	901					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTCGTCAATTGATTTGACCCC	0.458000													11	181					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207135708	207135708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207135708C>T	ENST00000324852.4	-	5	976	c.502G>A	c.(502-504)Gac>Aac	p.D168N	FCAMR_ENST00000450945.2_Missense_Mutation_p.D168N|FCAMR_ENST00000400962.3_Missense_Mutation_p.D168N	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	123	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						GCCACACGGTCACGATAGCGA	0.572000													24	51					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249913	52249913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52249913C>T	ENST00000595042.1	-	3	476	c.335G>A	c.(334-336)aGt>aAt	p.S112N	FPR1_ENST00000304748.4_Missense_Mutation_p.S112N	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	112					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CAGGAAGACACTTCCGAACAA	0.547000													21	69					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148384332	148384332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148384332G>A	ENST00000515425.1	-	17	3910	c.3809C>T	c.(3808-3810)cCc>cTc	p.P1270L	SH3TC2_ENST00000512049.1_Missense_Mutation_p.P1263L|SH3TC2_ENST00000538184.1_3'UTR|SH3TC2_ENST00000502274.1_Missense_Mutation_p.P132L	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1270							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACCCGGAGGGCCTGCTGTG	0.642000													9	23					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202161	56202161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56202161G>A	ENST00000361673.3	-	5	5471	c.5258C>T	c.(5257-5259)gCc>gTc	p.A1753V		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1753							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTTAAGAAAGGCTGAGTTCTT	0.408000													45	119					0	0	1	0	0
NGDN	25983	broad.mit.edu	37	14	23944473	23944473	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23944473C>T	ENST00000397154.3	+	4	251	c.238C>T	c.(238-240)Ctt>Ttt	p.L80F	NGDN_ENST00000408901.3_Missense_Mutation_p.L80F			Q8NEJ9	NGDN_HUMAN	neuroguidin, EIF4E binding protein	80	Necessary for interaction with EIF4E (By similarity).				regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus		p.L80V(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	12	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		AGGAGGATCTCTTCAGGGACA	0.468000													41	69					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64675261	64675261	+	Silent	SNP	G	G	A	rs112442396		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64675261G>A	ENST00000421419.2	-	17	2580	c.2466C>T	c.(2464-2466)atC>atT	p.I822I	ATG2A_ENST00000377264.3_Silent_p.I822I			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	822							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						TGGGCAGAAAGATGTGGACAC	0.632000													7	24					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27458130	27458130	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27458130C>T	ENST00000264705.4	+	24	3966	c.3804C>T	c.(3802-3804)ttC>ttT	p.F1268F	CAD_ENST00000403525.1_Silent_p.F1205F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1268	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AGTTCTCCTTCTCCCGCTTGG	0.617000													9	76					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26219491	26219491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26219491G>A	ENST00000335473.7	+	13	2791	c.2541G>A	c.(2539-2541)atG>atA	p.M847I	MYO18B_ENST00000536101.1_Missense_Mutation_p.M847I|MYO18B_ENST00000407587.2_Missense_Mutation_p.M847I	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	847	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGCAGTTCATGAGGTTTGAGT	0.577000													22	52					0	0	1	0	0
LRIF1	55791	broad.mit.edu	37	1	111494481	111494481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111494481G>A	ENST00000369763.4	-	2	1415	c.1025C>T	c.(1024-1026)cCt>cTt	p.P342L	LRIF1_ENST00000485275.2_Intron|LRIF1_ENST00000494675.1_Intron|RP11-96K19.2_ENST00000440689.1_RNA	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						CGTCCCACTAGGATCGATGGT	0.343000													42	141					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43299342	43299342	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43299342G>A	ENST00000290650.4	-	30	3428	c.3350C>T	c.(3349-3351)tCg>tTg	p.S1117L	UBR1_ENST00000568782.1_5'UTR|UBR1_ENST00000382177.2_3'UTR	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	1117					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GACACAGGCCGATAATACCAT	0.423000													40	120					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51562358	51562358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:51562358G>A	ENST00000298239.6	+	3	229	c.197G>A	c.(196-198)aGg>aAg	p.R66K	MSMB_ENST00000358559.2_Silent_p.K101K	NM_138634.2	NP_619540.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	0						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						TGGAGAAGAAGGACCCAAAAA	0.468000													18	169					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46916050	46916050	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46916050C>T	ENST00000307522.3	-	1	791	c.18G>A	c.(16-18)gaG>gaA	p.E6E		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	6						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		agtcgacgtcctccccgatct	0.602000													8	46					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41318429	41318429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41318429C>T	ENST00000551295.2	+	6	588	c.471C>T	c.(469-471)ctC>ctT	p.L157L	CNTN1_ENST00000360099.3_Silent_p.L157L|CNTN1_ENST00000547702.1_Silent_p.L157L|CNTN1_ENST00000347616.1_Silent_p.L157L|CNTN1_ENST00000348761.2_Silent_p.L146L|CNTN1_ENST00000547849.1_Silent_p.L157L	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	157	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGGTGCTTCTCTGTGACCCCC	0.378000													13	46					0	0	1	0	0
UNC45A	55898	broad.mit.edu	37	15	91492021	91492021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91492021C>T	ENST00000394275.2	+	16	2665	c.1830C>T	c.(1828-1830)ccC>ccT	p.P610P	UNC45A_ENST00000418476.2_Silent_p.P625P	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	625					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGCAGCACCCCAAGGTGAGGG	0.577000													8	17					0	0	1	0	0
DSPP	1834	broad.mit.edu	37	4	88534406	88534406	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88534406A>T	ENST00000399271.1	+	4	1188	c.1068A>T	c.(1066-1068)gaA>gaT	p.E356D	RP11-742B18.1_ENST00000506480.1_RNA|DSPP_ENST00000282478.7_Missense_Mutation_p.E356D	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	356					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		AACGCGTAGAAAATAGAATCA	0.413000													19	44					0	0	1	0	0
TSC22D1	8848	broad.mit.edu	37	13	45149450	45149450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:45149450G>A	ENST00000458659.2	-	1	1251	c.761C>T	c.(760-762)cCc>cTc	p.P254L	TSC22D1_ENST00000501704.2_Missense_Mutation_p.P254L	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	254					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TGGGCTTGAGGGTGGCCCACC	0.507000													23	48					0	0	1	0	0
OR1D5	8386	broad.mit.edu	37	17	2966227	2966227	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:2966227G>A	ENST00000575751.1	-	1	674	c.675C>T	c.(673-675)atC>atT	p.I225I		NM_014566.1	NP_055381.1	P58170	OR1D5_HUMAN	olfactory receptor, family 1, subfamily D, member 5	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|lung(10)	11						GCATTTGAAGGATGGTTCTGA	0.493000													10	26					0	0	1	0	0
MAX	4149	broad.mit.edu	37	14	65544090	65544090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65544090G>A	ENST00000557277.1	-	5	497	c.78C>T	c.(76-78)tcC>tcT	p.S26S	MAX_ENST00000555667.1_3'UTR|MAX_ENST00000341653.2_Intron|MAX_ENST00000358402.4_Intron|MAX_ENST00000284165.6_3'UTR|MAX_ENST00000555419.1_Intron|MAX_ENST00000358664.4_Intron|MAX_ENST00000556979.1_3'UTR|MAX_ENST00000555932.1_Intron			P61244	MAX_HUMAN	MYC associated factor X	0					transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		CTTCCATGAGGGAGGAAGAGA	0.413000													19	54					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122809232	122809232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122809232C>T	ENST00000194130.2	-	4	562	c.523G>A	c.(523-525)Gga>Aga	p.G175R	SLC13A1_ENST00000539873.1_Missense_Mutation_p.G111R	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	175						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TTGGTTGATCCGTTGAAGTAA	0.473000													14	45					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42368140	42368140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:42368140G>A	ENST00000298119.4	+	5	3308	c.2119G>A	c.(2119-2121)Gac>Aac	p.D707N	LRFN5_ENST00000554120.1_Intron|LRFN5_ENST00000554171.1_3'UTR	NM_152447.3	NP_689660.2	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	707						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GACTAATGTTGACCAGATTGT	0.284000										HNSCC(30;0.082)			19	132					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903240	6903240	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:6903240C>T	ENST00000486284.1	+	1	439	c.165C>T	c.(163-165)ttC>ttT	p.F55F	GRM7_ENST00000357716.4_Silent_p.F55F|GRM7_ENST00000403881.1_Silent_p.F55F|GRM7_ENST00000402647.2_Silent_p.F55F|GRM7_ENST00000389336.4_Silent_p.F55F	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	55					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GGGGGCTGTTCCCCGTGCACG	0.692000													3	9					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28229733	28229733	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28229733A>G	ENST00000305242.5	-	13	1837	c.1743_splice	c.e13-1	p.V582_splice	ARMC4_ENST00000537576.1_Splice_Site_p.V274_splice|ARMC4_ENST00000545014.1_Splice_Site_p.V107_splice	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	582							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TAGTAGAGCAACCTATAATAA	0.448000													33	65					0	0	1	0	0
TRBV7-8	28590	broad.mit.edu	37	7	142099651	142099651	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142099651G>A	ENST00000390359.3	-	0	189																											TACCAAAAAAGGGATACATGA	0.517000													11	44					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125769852	125769852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:125769852G>A	ENST00000346248.5	-	8	2141	c.1499C>T	c.(1498-1500)cCc>cTc	p.P500L	CHST15_ENST00000435907.1_Missense_Mutation_p.P500L	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	500					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						CTCACTTAAGGGCCCTAGAAT	0.547000													5	4					0	0	1	0	0
RAB3D	9545	broad.mit.edu	37	19	11448054	11448054	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11448054G>A	ENST00000222120.3	-	2	282	c.22C>T	c.(22-24)Cag>Tag	p.Q8*	RAB3D_ENST00000589655.1_Nonsense_Mutation_p.Q8*	NM_004283.3	NP_004274.1	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	8					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|ovary(2)	14						GGGCCTGCCTGGGTGTCTCCA	0.557000													39	104					0	0	1	0	0
KCND1	3750	broad.mit.edu	37	X	48826306	48826306	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48826306G>A	ENST00000218176.3	-	1	1670	c.373C>T	c.(373-375)Ccc>Tcc	p.P125S		NM_004979.4	NP_004970.3	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 1	125						voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	24						ACTAGCTCGGGAACCAGGCCG	0.622000													12	8					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130293171	130293171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130293171G>A	ENST00000358511.6	+	7	3380	c.3349G>A	c.(3349-3351)Gag>Aag	p.E1117K	COL6A6_ENST00000453409.2_Missense_Mutation_p.E1117K	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1117	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GTCCCAAGACGAGGTGGCCCA	0.577000													18	59					0	0	1	0	0
DYDC2	84332	broad.mit.edu	37	10	82122300	82122300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:82122300C>T	ENST00000372199.1	+	4	699	c.101C>T	c.(100-102)gCt>gTt	p.A34V	DYDC2_ENST00000372198.1_Missense_Mutation_p.A48V|DYDC2_ENST00000444807.2_Missense_Mutation_p.A34V|DYDC2_ENST00000372197.1_Missense_Mutation_p.A34V|DYDC2_ENST00000256039.2_Missense_Mutation_p.A34V			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	34							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			GAATACCTGGCTCACTGGCTT	0.498000													13	58					0	0	1	0	0
NDUFS2	4720	broad.mit.edu	37	1	161180451	161180451	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161180451C>T	ENST00000392179.4	+	9	1176	c.937C>T	c.(937-939)Cag>Tag	p.Q313*	NDUFS2_ENST00000476409.2_Nonsense_Mutation_p.Q215*|NDUFS2_ENST00000367993.3_Nonsense_Mutation_p.Q313*|NDUFS2_ENST00000465923.1_3'UTR	NM_001166159.1	NP_001159631.1	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	313					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)	18	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	TGTTTACGACCAGGTTGAGTT	0.527000													13	49					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839532	27839532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27839532G>A	ENST00000356790.2	+	3	354	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	37								p.E37*(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AGAGGAGGAAGAATCTCCCCC	0.517000													19	17					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108216912	108216912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108216912G>A	ENST00000273353.3	-	7	721	c.665C>T	c.(664-666)tCc>tTc	p.S222F		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	222	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTTTTTCCTGGATTCAATCAT	0.433000													25	164					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56058019	56058019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56058019G>A	ENST00000313022.2	-	1	547	c.520C>T	c.(520-522)Cgt>Tgt	p.R174C		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					AAAAAGTGACGAACTACATTT	0.438000													30	77					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45709910	45709910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45709910C>T	ENST00000291582.5	+	7	965	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	280	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		GGGCAGCGTTCCCGCCCCTCT	0.687000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				7	19					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103180703	103180703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103180703G>A	ENST00000424685.2	-	44	7030	c.6871C>T	c.(6871-6873)Ctt>Ttt	p.L2291F	RELN_ENST00000343529.5_Missense_Mutation_p.L2291F|RELN_ENST00000428762.1_Missense_Mutation_p.L2291F			P78509	RELN_HUMAN	reelin	2291					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.L2291F(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACCAGCGAAGGCGAGTAGAA	0.498000													34	94					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236898958	236898958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236898958G>A	ENST00000366578.4	+	8	887	c.721G>A	c.(721-723)Gat>Aat	p.D241N	ACTN2_ENST00000542672.1_Intron|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_Intron	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	241	Actin-binding.|CH 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CCCTAAACCCGATGAAAGAGC	0.537000													21	64					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48528861	48528861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48528861C>T	ENST00000435803.1	+	48	13235	c.13211C>T	c.(13210-13212)tCc>tTc	p.S4404F	ABCA13_ENST00000544596.1_Missense_Mutation_p.S134F	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4404					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGTTTTCATTCCCTACCTTCC	0.378000													10	21					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19335212	19335212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19335212G>A	ENST00000252575.5	+	5	791	c.748G>A	c.(748-750)Gat>Aat	p.D250N		NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	250	Link 1.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GGAACTCTACGATGTGTATTG	0.592000													27	97					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63447955	63447955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:63447955G>A	ENST00000322893.7	-	6	845	c.577C>T	c.(577-579)Cct>Tct	p.P193S	KCNH5_ENST00000420622.2_Missense_Mutation_p.P193S|KCNH5_ENST00000394964.2_Missense_Mutation_p.P135S|KCNH5_ENST00000394968.1_Missense_Mutation_p.P135S	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	193					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTATACTGAGGAAGGATATCT	0.358000													28	48					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179590249	179590249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179590249C>T	ENST00000589042.1	-	71	20906	c.20682G>A	c.(20680-20682)gtG>gtA	p.V6894V	TTN_ENST00000342992.6_Silent_p.V5650V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000591111.1_Silent_p.V6577V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6577	Ig-like 50.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTCTAATCACTTCTTCCT	0.438000													24	59					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73474816	73474816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73474816C>T	ENST00000252034.7	+	25	2131	c.1732C>T	c.(1732-1734)Cct>Tct	p.P578S	ELN_ENST00000380553.4_Missense_Mutation_p.P442S|ELN_ENST00000380562.4_Missense_Mutation_p.P584S|ELN_ENST00000358929.4_Missense_Mutation_p.P613S|ELN_ENST00000414324.1_Missense_Mutation_p.P554S|ELN_ENST00000320399.6_Missense_Mutation_p.P578S|ELN_ENST00000429192.1_Missense_Mutation_p.P564S|ELN_ENST00000380584.4_Missense_Mutation_p.P530S|CTB-51J22.1_ENST00000435932.1_RNA|ELN_ENST00000445912.1_Missense_Mutation_p.P578S|ELN_ENST00000458204.1_Missense_Mutation_p.P568S|ELN_ENST00000357036.5_Missense_Mutation_p.P583S|ELN_ENST00000380576.5_Missense_Mutation_p.P559S|ELN_ENST00000320492.7_Missense_Mutation_p.P497S|ELN_ENST00000380575.4_Missense_Mutation_p.P549S	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	607	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGCTGGTGTTCCTGGCTTCGG	0.627000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						27	52					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72425262	72425262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72425262G>A	ENST00000359373.5	-	4	1465	c.614C>T	c.(613-615)cCt>cTt	p.P205L	ARAP1_ENST00000334211.8_5'UTR|ARAP1_ENST00000393609.3_Missense_Mutation_p.P205L|ARAP1_ENST00000455638.2_Missense_Mutation_p.P205L|ARAP1_ENST00000429686.1_5'UTR|ARAP1_ENST00000426523.1_5'UTR			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	205					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						TGGAGAGGGAGGCTGGGGAGG	0.647000													2	0					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10452333	10452333	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10452333G>A	ENST00000397077.1	-	5	941	c.366C>T	c.(364-366)tcC>tcT	p.S122S	ATP2B2_ENST00000352432.4_Silent_p.S122S|ATP2B2_ENST00000343816.4_Silent_p.S122S|ATP2B2_ENST00000383800.4_Silent_p.S122S|ATP2B2_ENST00000360273.2_Silent_p.S122S			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	122					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GGTGGTAGAAGGACAGCCCCA	0.642000													74	215					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904562	55904562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55904562C>T	ENST00000301529.1	-	1	632	c.633G>A	c.(631-633)atG>atA	p.M211I		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M211I(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					GAACTGTAATCATGGAAAAAA	0.358000													15	85					0	0	1	0	0
PLD6	201164	broad.mit.edu	37	17	17109301	17109301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:17109301G>A	ENST00000321560.3	-	1	328	c.300C>T	c.(298-300)gcC>gcT	p.A100A	RP11-45M22.4_ENST00000427497.3_Intron	NM_178836.3	NP_849158.2	Q8N2A8	PLD6_HUMAN	phospholipase D family, member 6	100					DNA methylation involved in gamete generation|lipid catabolic process|meiosis|mitochondrial fusion|P granule organization|piRNA metabolic process|spermatid development	integral to membrane|mitochondrial outer membrane	cardiolipin hydrolase activity|protein homodimerization activity			endometrium(1)|lung(1)	2						GGCTGGAGAAGGCGAACAGGC	0.726000													2	0					0	0	1	0	0
SLC35B3	51000	broad.mit.edu	37	6	8422706	8422706	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:8422706G>A	ENST00000379660.4	-	5	1020	c.571C>T	c.(571-573)Caa>Taa	p.Q191*	SLC35B3_ENST00000339306.5_Nonsense_Mutation_p.Q191*	NM_001142540.1|NM_001142541.1|NM_015948.3	NP_001136012.1|NP_001136013.1|NP_057032.2	Q9H1N7	S35B3_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3	191					transmembrane transport	Golgi membrane|integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(1)|prostate(1)	15	Ovarian(93;0.0569)					ACTATACCTTGAATAAAAACT	0.333000													12	54					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113679953	113679953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113679953G>A	ENST00000003302.4	-	17	2064	c.1996C>T	c.(1996-1998)Caa>Taa	p.Q666*	USP28_ENST00000260188.5_Nonsense_Mutation_p.Q666*|USP28_ENST00000544967.1_Nonsense_Mutation_p.Q374*|USP28_ENST00000545540.1_Nonsense_Mutation_p.Q541*	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	666					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCTGACATTTGATCTGATTCA	0.438000													124	311					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127958729	127958729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:127958729G>A	ENST00000335247.7	-	3	487	c.357C>T	c.(355-357)ttC>ttT	p.F119F	CYP27C1_ENST00000409327.1_Silent_p.F119F	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	119						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		AGGACCTGCAGAATTCCCGCC	0.522000													12	187					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69107480	69107480	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69107480C>T	ENST00000332644.5	-	2	212	c.51G>A	c.(49-51)acG>acA	p.T17T		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	17					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity	p.T17T(2)		breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						AAATAAAGATCGTAGTCCATA	0.388000													36	49					0	0	1	0	0
USP46	64854	broad.mit.edu	37	4	53476724	53476724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:53476724G>A	ENST00000441222.2	-	5	805	c.621C>T	c.(619-621)tcC>tcT	p.S207S	USP46_ENST00000508499.1_Silent_p.S200S|USP46_ENST00000451218.2_Silent_p.S180S	NM_022832.3	NP_073743.2	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46	207					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)	12			LUSC - Lung squamous cell carcinoma(32;0.0295)			AGTGGGTAATGGATGTATTCT	0.363000													15	31					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35954365	35954365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35954365C>T	ENST00000274278.3	-	7	1868	c.1511G>A	c.(1510-1512)gGg>gAg	p.G504E		NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	504						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAGCAGCTTCCCACAAAGCCA	0.587000													22	49					0	0	1	0	0
MPV17	4358	broad.mit.edu	37	2	27532804	27532804	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27532804C>A	ENST00000402310.1	-	7	461	c.454G>T	c.(454-456)Gtc>Ttc	p.V152F	MPV17_ENST00000405983.1_Silent_p.L184L|MPV17_ENST00000405076.1_Silent_p.L106L|MPV17_ENST00000402722.1_3'UTR|MPV17_ENST00000233545.2_Silent_p.L169L|MPV17_ENST00000380044.1_Silent_p.L169L|MPV17_ENST00000357186.6_Silent_p.L113L			P39210	MPV17_HUMAN	MpV17 mitochondrial inner membrane protein	0					cellular response to reactive oxygen species|glomerular basement membrane development|homeostatic process|inner ear development|mitochondrial genome maintenance|regulation of reactive oxygen species metabolic process	integral to peroxisomal membrane|mitochondrial inner membrane				lung(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTCCAGGACAGGTAGGAGT	0.517000													13	36					0.00010058	0.000100735	1	1	0
ADAM23	8745	broad.mit.edu	37	2	207429762	207429762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207429762C>T	ENST00000264377.3	+	14	1692	c.1364C>T	c.(1363-1365)tCc>tTc	p.S455F	ADAM23_ENST00000374415.3_Missense_Mutation_p.S455F|ADAM23_ENST00000374416.1_Missense_Mutation_p.S455F	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	455	Peptidase M12B.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TGCACAGAATCCTGGGGTGGC	0.363000													34	101					0	0	1	0	0
ACSL6	23305	broad.mit.edu	37	5	131308971	131308971	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131308971C>T	ENST00000379264.2	-	12	1299	c.1191G>A	c.(1189-1191)cgG>cgA	p.R397R	ACSL6_ENST00000379244.1_Silent_p.R372R|ACSL6_ENST00000357096.1_Silent_p.R297R|ACSL6_ENST00000379249.3_Silent_p.R372R|ACSL6_ENST00000296869.4_Silent_p.R397R|ACSL6_ENST00000379240.1_Silent_p.R372R|ACSL6_ENST00000431707.1_Silent_p.R352R|ACSL6_ENST00000379255.1_Silent_p.R297R|ACSL6_ENST00000379272.2_Silent_p.R387R|ACSL6_ENST00000544770.1_Silent_p.R281R|ACSL6_ENST00000543479.1_Silent_p.R372R|ACSL6_ENST00000379246.1_Silent_p.R383R	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	372					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGTCGTACATCCGGTTCAGCA	0.562000													22	68					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192700856	192700856	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:192700856C>T	ENST00000304141.4	-	2	1400	c.1071G>A	c.(1069-1071)gaG>gaA	p.E357E		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	357						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	AGGTCGCCTTCTCAGCAGCCT	0.572000													13	165					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409322	59409322	+	Missense_Mutation	SNP	C	C	T	rs150039957	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:59409322C>T	ENST00000301645.3	-	3	886	c.749G>A	c.(748-750)aGg>aAg	p.R250K		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	250					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GATGCTTTCCCTCTTTTGGAG	0.542000									Neonatal Giant Cell Hepatitis				31	224					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49000670	49000670	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49000670C>T	ENST00000600059.1	-	11	3883	c.3656G>A	c.(3655-3657)gGg>gAg	p.G1219E	LMTK3_ENST00000270238.3_Missense_Mutation_p.G1248E					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTCGCTGTTCCCCTGAGGGGG	0.652000													22	50					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165386283	165386283	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165386283C>T	ENST00000359842.5	-	4	919	c.617G>A	c.(616-618)aGg>aAg	p.R206K	RXRG_ENST00000470566.1_5'UTR	NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	206	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CTCACCTTCCCTCTTCATGCC	0.512000													14	59					0	0	1	0	0
RPLP0P6	220717	broad.mit.edu	37	2	38708951	38708951	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:38708951C>T	ENST00000417039.1	-	0	696																											GAAGTGACATCGTCTTTAAAC	0.552000													5	14					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160732029	160732029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160732029C>T	ENST00000263636.4	-	12	1927	c.1900G>A	c.(1900-1902)Gaa>Aaa	p.E634K	LY75-CD302_ENST00000505052.1_Missense_Mutation_p.E634K|LY75_ENST00000553424.1_Missense_Mutation_p.E634K|LY75_ENST00000554112.1_Missense_Mutation_p.E634K|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.E634K	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		GGGGATGCTTCTTCAGGCCCA	0.473000													49	160					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94083536	94083536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94083536C>T	ENST00000553484.1	+	29	4330	c.4176C>T	c.(4174-4176)tgC>tgT	p.C1392C	UNC79_ENST00000555664.1_Silent_p.C1370C|UNC79_ENST00000393151.2_Silent_p.C1370C|UNC79_ENST00000256339.4_Silent_p.C1193C			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1370						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TCAAATACTGCTCTTGTCCTC	0.453000													40	102					0	0	1	0	0
TTLL2	83887	broad.mit.edu	37	6	167754223	167754223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:167754223C>T	ENST00000239587.5	+	3	923	c.835C>T	c.(835-837)Cgg>Tgg	p.R279W		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	279	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		AGGGTTGGTTCGGTTTGCCAC	0.398000													78	119					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909307	123909307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123909307C>T	ENST00000330487.5	-	1	410	c.402G>A	c.(400-402)atG>atA	p.M134I		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GCCCAGTCATCATGTTGGTGT	0.542000													67	206					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33552743	33552743	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:33552743G>A	ENST00000265371.4	-	5	1014	c.489C>T	c.(487-489)ttC>ttT	p.F163F	NRP1_ENST00000374821.5_Silent_p.F163F|NRP1_ENST00000374823.5_Silent_p.F163F|NRP1_ENST00000374867.2_Silent_p.F163F|NRP1_ENST00000395995.1_Silent_p.F163F|NRP1_ENST00000374822.4_Silent_p.F163F|NRP1_ENST00000374816.3_Silent_p.F163F			O14786	NRP1_HUMAN	neuropilin 1	163	CUB 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	ATTTTTCAGGGAATCCGGGGG	0.423000													67	226					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78073340	78073340	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78073340C>T	ENST00000397545.4	+	20	3222	c.3195C>T	c.(3193-3195)atC>atT	p.I1065I		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1065					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TTTCAGAGATCGTGGCCCTGC	0.562000													21	59					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124438117	124438117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124438117G>A	ENST00000360013.3	+	60	8888	c.8761G>A	c.(8761-8763)Gaa>Aaa	p.E2921K	KALRN_ENST00000291478.4_Missense_Mutation_p.E1224K|KALRN_ENST00000428018.2_Missense_Mutation_p.E1192K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2920	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.E2921*(1)|p.E1224*(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GATCTTACAGGAAGATTTTCG	0.522000													12	64					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28865888	28865888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:28865888G>A	ENST00000422425.2	+	57	4349	c.4305G>A	c.(4303-4305)agG>agA	p.R1435R	PLB1_ENST00000541605.1_Silent_p.R411R|AC074011.2_ENST00000431376.1_RNA|PLB1_ENST00000327757.5_Silent_p.R1446R	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1446	Necessary for membrane localization (By similarity).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GTGGCCGGAGGGAAGATCCTC	0.652000													6	6					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53839063	53839063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53839063G>A	ENST00000288139.3	+	46	5817	c.5699G>A	c.(5698-5700)aGg>aAg	p.R1900K	CACNA1D_ENST00000544977.1_Missense_Mutation_p.R259K|CACNA1D_ENST00000422281.2_Missense_Mutation_p.R1856K|CACNA1D_ENST00000350061.5_Missense_Mutation_p.R1880K	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1880					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GACTCTGAGAGGCCCCGAGGC	0.537000													23	113					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20482730	20482730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20482730G>A	ENST00000305045.2	-	1	622	c.623C>T	c.(622-624)tCc>tTc	p.S208F		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ACAGCTCAAGGAAAGCAACCC	0.507000													20	38					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145629432	145629432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:145629432G>A	ENST00000296575.3	+	7	1925	c.1270G>A	c.(1270-1272)Gtg>Atg	p.V424M		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	424						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GCCCCCCGAAGTGTTTGCTCA	0.532000													16	69					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43594307	43594307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43594307G>A	ENST00000395891.1	+	29	5232	c.4627G>A	c.(4627-4629)Gaa>Aaa	p.E1543K	HECW1_ENST00000453890.1_Missense_Mutation_p.E1509K	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1543	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.E1522Q(1)		NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CGTGCCCTACGAAGGCTTCGC	0.562000													9	35					0	0	1	0	0
FAM26D	221301	broad.mit.edu	37	6	116879329	116879329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116879329G>A	ENST00000368596.3	+	2	944	c.900G>A	c.(898-900)gaG>gaA	p.E300E	FAM26D_ENST00000405399.1_Silent_p.E157E|FAM26D_ENST00000368597.2_Silent_p.E114E|FAM26D_ENST00000416171.2_Silent_p.E156E			Q5JW98	FA26D_HUMAN	family with sequence similarity 26, member D	300						integral to membrane				endometrium(1)|lung(5)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0458)|OV - Ovarian serous cystadenocarcinoma(136;0.0694)|Epithelial(106;0.222)		GGGTGGATGAGGATAATGAGG	0.408000													16	62					0	0	1	0	0
B3GALNT1	8706	broad.mit.edu	37	3	160803840	160803840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:160803840G>A	ENST00000392781.2	-	8	1450	c.703C>T	c.(703-705)Cct>Tct	p.P235S	B3GALNT1_ENST00000473285.1_Missense_Mutation_p.P235S|B3GALNT1_ENST00000488170.1_Missense_Mutation_p.P235S|B3GALNT1_ENST00000320474.4_Missense_Mutation_p.P235S|B3GALNT1_ENST00000392780.1_Missense_Mutation_p.P235S|B3GALNT1_ENST00000392779.2_Missense_Mutation_p.P235S|B3GALNT1_ENST00000417187.1_Intron	NM_001038628.1	NP_001033717.1	O75752	B3GL1_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	235					protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			CAGTATGGAGGGAACACCTTG	0.378000													25	74					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86813153	86813153	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86813153C>T	ENST00000441037.2	+	13	1799	c.1704C>T	c.(1702-1704)ttC>ttT	p.F568F	AGBL1_ENST00000421325.2_Silent_p.F568F|AGBL1_ENST00000389298.3_Silent_p.F299F	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	568					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding	p.F568F(1)		NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TCTGCAGGTTCGAGTATGACT	0.473000													10	36					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923865	24923865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24923865C>T	ENST00000329468.2	+	1	3325	c.2851C>T	c.(2851-2853)Cca>Tca	p.P951S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GTTAACATCACCATATACTGC	0.478000													24	65					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54450144	54450144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54450144G>A	ENST00000566473.2	+	6	748	c.748G>A	c.(748-750)Gct>Act	p.A250T	ANKFN1_ENST00000318698.2_Missense_Mutation_p.A250T			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	250										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						GCAGCTGAAAGCTTGGGAGTG	0.498000													42	118					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90167845	90167845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90167845C>T	ENST00000268138.7	+	20	4409	c.4304C>T	c.(4303-4305)cCt>cTt	p.P1435L	KIF7_ENST00000558928.1_Intron|TICRR_ENST00000560985.1_Missense_Mutation_p.P1434L					TOPBP1-interacting checkpoint and replication regulator																		CAGTCTCCTCCTGAAAGACGG	0.582000													67	82					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20849204	20849204	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20849204G>A	ENST00000262715.5	-	33	4688	c.4647_splice	c.e33-1	p.L1550_splice	TEP1_ENST00000556935.1_Splice_Site_p.L1442_splice|TEP1_ENST00000545983.1_5'UTR	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1550					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CCGCTCTGGAGCTGAGAAGGT	0.517000													9	32					0	0	1	0	0
GLRA1	2741	broad.mit.edu	37	5	151230975	151230975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:151230975G>A	ENST00000274576.4	-	7	1180	c.888C>T	c.(886-888)tcC>tcT	p.S296S	GLRA1_ENST00000545569.1_Silent_p.S213S|GLRA1_ENST00000455880.2_Silent_p.S296S|GLRA1_ENST00000471351.2_5'UTR	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	296					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTCGAGAGCCGGAGCTCTGGG	0.542000													21	44					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60348221	60348221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60348221C>T	ENST00000360469.5	+	4	647	c.559C>T	c.(559-561)Ccg>Tcg	p.P187S	CDH4_ENST00000543233.1_Missense_Mutation_p.P113S	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	187	Cadherin 1.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CGGGCCCTTCCCGCAGCAGCT	0.701000													5	4					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7254553	7254553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7254553G>A	ENST00000266542.4	-	3	523	c.431C>T	c.(430-432)tCc>tTc	p.S144F	C1RL_ENST00000545337.1_Missense_Mutation_p.S144F|C1RL_ENST00000544702.1_Missense_Mutation_p.S144F|C1RL_ENST00000545280.1_Intron	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	144	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GTTCTCCGAGGAAGGCTGTGT	0.622000													37	108					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18707512	18707512	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18707512G>A	ENST00000392386.3	-	6	1137	c.944C>T	c.(943-945)cCc>cTc	p.P315L		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	315	Fibronectin type-III 2.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						GATGCCAAAGGGGTTGCAGCG	0.637000													7	34					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058160	79058160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79058160G>A	ENST00000388820.4	-	19	4303	c.4093C>T	c.(4093-4095)Cct>Tct	p.P1365S		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1365					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GGCACCTCAGGGCTGAGGGAC	0.667000													15	22					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2161844	2161844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:2161844C>T	ENST00000382203.1	+	28	4349	c.4140C>T	c.(4138-4140)ccC>ccT	p.P1380P	SMARCA2_ENST00000302401.3_Silent_p.P86P|SMARCA2_ENST00000382185.1_Silent_p.P44P|SMARCA2_ENST00000382194.1_Silent_p.P1380P|SMARCA2_ENST00000382186.1_Silent_p.P44P|SMARCA2_ENST00000349721.2_Silent_p.P1380P|SMARCA2_ENST00000324954.5_Silent_p.P44P|SMARCA2_ENST00000357248.2_Silent_p.P1380P			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1380					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CACCAAATCCCCCCAAACTGA	0.438000													15	28					0	0	1	0	0
LINC00669	647946	broad.mit.edu	37	18	37202102	37202102	+	RNA	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:37202102T>C	ENST00000591629.1	-	0	282					NR_024391.1																						agactctaggttggatggccc	0.423000													19	60					0	0	1	0	0
TTC24	164118	broad.mit.edu	37	1	156554962	156554962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156554962G>A	ENST00000368236.3	+	8	1431	c.1395G>A	c.(1393-1395)caG>caA	p.Q465Q	TTC24_ENST00000368237.3_Silent_p.Q465Q|TTC24_ENST00000495690.1_3'UTR	NM_001105669.2	NP_001099139.2	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	465							binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	20	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGGCCACCAGAAGAAAAAAG	0.577000													20	29					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6062186	6062186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6062186C>T	ENST00000409021.3	-	11	2058	c.1609G>A	c.(1609-1611)Gaa>Aaa	p.E537K	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.E372K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.E537K|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.E537K|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.E352K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	537	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCCAAATCTTCGATTTTGGCC	0.532000													62	118					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51261219	51261219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:51261219G>A	ENST00000395542.2	-	3	497	c.313C>T	c.(313-315)Ctt>Ttt	p.L105F	COBL_ENST00000395540.2_Missense_Mutation_p.L105F|COBL_ENST00000441453.1_Missense_Mutation_p.L105F|COBL_ENST00000265136.7_Missense_Mutation_p.L105F			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	105										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CGAATTTCAAGGGCATGGTGG	0.408000													6	82					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	313576	313576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:313576G>A	ENST00000264819.4	-	8	733	c.723C>T	c.(721-723)ttC>ttT	p.F241F		NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	241	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCTGTACAGGAACTCCTCCA	0.632000													48	124					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274505	39274505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39274505C>T	ENST00000391413.2	-	1	101	c.63G>A	c.(61-63)caG>caA	p.Q21Q		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	21	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGCAGGTCTCCTGGCAGAGGT	0.612000													10	29					0	0	1	0	0
KCNG1	3755	broad.mit.edu	37	20	49626345	49626345	+	Silent	SNP	C	C	T	rs140916173		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49626345C>T	ENST00000371571.4	-	2	816	c.531G>A	c.(529-531)gcG>gcA	p.A177A	KCNG1_ENST00000396017.3_Silent_p.A177A|RP5-955M13.4_ENST00000424566.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	177						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						CCACCATCTCCGCGAACTCCT	0.701000													22	94					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37328890	37328890	+	Missense_Mutation	SNP	G	G	A	rs146404001	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37328890G>A	ENST00000262825.5	+	9	1331	c.1114G>A	c.(1114-1116)Gaa>Aaa	p.E372K	CSF2RB_ENST00000536485.1_Missense_Mutation_p.E313K|CSF2RB_ENST00000406230.1_Missense_Mutation_p.E372K|CSF2RB_ENST00000403662.3_Missense_Mutation_p.E366K	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	366	Fibronectin type-III 2.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	AATGCGATACGAACACATAGA	0.567000													9	32					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84050127	84050127	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84050127G>A	ENST00000299709.3	-	8	1158	c.1159C>T	c.(1159-1161)Cca>Tca	p.P387S		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	387					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						GCCTCACCTGGGAAGATGAAG	0.567000													15	41					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104432595	104432595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104432595G>A	ENST00000361820.3	-	3	2699	c.2099C>T	c.(2098-2100)cCa>cTa	p.P700L		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	700					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CAAACCAAATGGACTCTTCCA	0.493000													11	135					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890739	55890739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55890739G>A	ENST00000313472.3	+	1	891	c.891G>A	c.(889-891)gtG>gtA	p.V297V		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					ACAGAGAAGTGAAAAATGCTC	0.363000													63	126					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141135801	141135801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141135801G>A	ENST00000389484.3	-	68	11557	c.10586C>T	c.(10585-10587)tCt>tTt	p.S3529F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3529	LDL-receptor class A 26.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAACCTTGAAGAAACACAGTC	0.408000										TSP Lung(27;0.18)			17	40					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72938120	72938120	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72938120C>T	ENST00000328801.4	+	3	615	c.615C>T	c.(613-615)ttC>ttT	p.F205F		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	205						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					AGATGGTCTTCATCGGCGTCC	0.557000													12	34					0	0	1	0	0
KLRK1	22914	broad.mit.edu	37	12	10531183	10531183	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10531183G>A	ENST00000240618.6	-	6	539	c.399C>T	c.(397-399)agC>agT	p.S133S	RP11-277P12.20_ENST00000500682.1_RNA|KLRK1_ENST00000540818.1_Silent_p.S133S|KLRC4-KLRK1_ENST00000539300.1_3'UTR	NM_001199805.1|NM_007360.3	NP_001186734.1|NP_031386.2	P26718	NKG2D_HUMAN	killer cell lectin-like receptor subfamily K, member 1	133	C-type lectin.				natural killer cell activation|T cell costimulation	integral to plasma membrane	sugar binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)	9						CTTTCAGAAGGCTGGCATTTT	0.353000													39	61					0	0	1	0	0
SERPINB11	89778	broad.mit.edu	37	18	61387373	61387373	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61387373C>T	ENST00000544088.1	+	0	664				SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				GTTAAAAGTCCTTTTCAGCTA	0.328000													4	49					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713684	46713684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46713684G>A	ENST00000318962.4	-	23	2563	c.2480C>T	c.(2479-2481)tCc>tTc	p.S827F	ALS2CL_ENST00000415953.1_Missense_Mutation_p.S827F|ALS2CL_ENST00000383742.3_Missense_Mutation_p.S174F	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	827	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CCTGACCAGGGAGTACCTCTG	0.647000													16	26					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119025518	119025518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119025518C>T	ENST00000307417.3	+	6	943	c.579C>T	c.(577-579)tgC>tgT	p.C193C	ABCG4_ENST00000449422.2_Silent_p.C193C|ABCG4_ENST00000531739.1_Silent_p.C193C	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	193	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGATGTCGTGCTCCCACACGA	0.642000													45	140					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28843514	28843514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28843514C>T	ENST00000564304.1	+	11	1493	c.1328C>T	c.(1327-1329)cCt>cTt	p.P443L	ATXN2L_ENST00000395547.2_Intron|ATXN2L_ENST00000340394.8_Intron|ATXN2L_ENST00000336783.4_Intron|ATXN2L_ENST00000325215.6_Intron|ATXN2L_ENST00000570200.1_Intron|RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000382686.4_Intron			Q8WWM7	ATX2L_HUMAN	ataxin 2-like	440						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						ACAGCTCCCCCTTTTCTTCCA	0.547000													9	47					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587388	36587388	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36587388C>T	ENST00000332987.1	-	7	1201	c.779G>A	c.(778-780)tGg>tAg	p.W260*	APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000352371.1_Nonsense_Mutation_p.W263*|APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000404685.3_3'UTR			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	264					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						TACATATCGCCAAGCAATCAA	0.478000													19	43					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33030907	33030907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:33030907C>T	ENST00000340811.4	-	3	1015	c.907G>A	c.(907-909)Gaa>Aaa	p.E303K	PKP2_ENST00000070846.6_Missense_Mutation_p.E303K	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	303					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GGCCCAGCTTCCCTCAGCGTG	0.667000													5	53					0	0	1	0	0
RAB17	64284	broad.mit.edu	37	2	238494746	238494746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238494746G>A	ENST00000264601.3	-	2	681	c.52C>T	c.(52-54)Cgt>Tgt	p.R18C	RAB17_ENST00000416106.1_5'UTR|RAB17_ENST00000538644.1_5'UTR|RAB17_ENST00000409822.1_Intron|RAB17_ENST00000409576.1_Intron	NM_022449.3	NP_071894.1	Q9H0T7	RAB17_HUMAN	RAB17, member RAS oncogene family	18					protein transport|small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(1)	4		Renal(207;0.00272)|Breast(86;0.00297)|all_hematologic(139;0.182)|Ovarian(221;0.221)		Epithelial(121;9.36e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.26e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000354)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.026)		TTGAACACACGGGGCTGGCTG	0.592000													33	61					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332873	70332873	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70332873G>A	ENST00000338508.4	-	32	3527	c.3528C>T	c.(3526-3528)tcC>tcT	p.S1176S	SHANK2_ENST00000449833.2_Silent_p.S580S|SHANK2_ENST00000423696.2_Silent_p.S796S|SHANK2_ENST00000409161.1_Silent_p.S579S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	796					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTTTGGACGTGGAATTCAGCG	0.697000													10	82					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15967631	15967631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:15967631G>A	ENST00000350896.3	-	9	1327	c.1130C>T	c.(1129-1131)tCa>tTa	p.S377L	MSR1_ENST00000445506.2_Missense_Mutation_p.S458L|MSR1_ENST00000262101.5_Missense_Mutation_p.S440L|MSR1_ENST00000355282.2_Missense_Mutation_p.S377L	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	440	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TTCAGAATGTGAACAGGCTCT	0.378000													42	87					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101720309	101720309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:101720309G>A	ENST00000251127.6	-	39	4488	c.4407C>T	c.(4405-4407)caC>caT	p.H1469H		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1469						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTATTTGAAAGTGGCGAAGAT	0.363000													17	53					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64669638	64669638	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64669638G>A	ENST00000421419.2	-	29	4035	c.3921C>T	c.(3919-3921)ctC>ctT	p.L1307L	ATG2A_ENST00000377264.3_Silent_p.L1305L			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1305							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						ACGCCTGAGGGAGGTGGCCAC	0.647000													22	47					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33003898	33003898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:33003898G>A	ENST00000340811.4	-	5	1288	c.1180C>T	c.(1180-1182)Ctt>Ttt	p.L394F	PKP2_ENST00000070846.6_Missense_Mutation_p.L394F	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	394					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					ATGCCACGAAGCTGGTTAACC	0.408000													24	54					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43596087	43596087	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:43596087G>A	ENST00000355710.3	+	2	486	c.254G>A	c.(253-255)tGg>tAg	p.W85*	RET_ENST00000340058.5_Nonsense_Mutation_p.W85*	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	85					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	GAGAACAACTGGATCTGCATC	0.637000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				6	29					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68696733	68696733	+	Silent	SNP	C	C	T	rs145314949	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68696733C>T	ENST00000255078.3	+	8	1254	c.1143C>T	c.(1141-1143)ctC>ctT	p.L381L		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	381	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCCAGGCCCTCGAGGCGAGCT	0.627000													24	85					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61115696	61115696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61115696C>T	ENST00000277705.6	-	2	171	c.70G>A	c.(70-72)Gaa>Aaa	p.E24K	FAM13C_ENST00000419214.2_Missense_Mutation_p.E24K|FAM13C_ENST00000373867.3_5'UTR|FAM13C_ENST00000435852.2_Missense_Mutation_p.E24K|FAM13C_ENST00000422313.2_Missense_Mutation_p.E24K|FAM13C_ENST00000468840.2_5'UTR|FAM13C_ENST00000373868.2_Missense_Mutation_p.E24K|FAM13C_ENST00000442566.3_Missense_Mutation_p.E24K			Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	24										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						ACTGGATCTTCGTCACACCTG	0.418000													26	61					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3889591	3889591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3889591C>T	ENST00000520002.1	-	4	1001	c.446G>A	c.(445-447)gGa>gAa	p.G149E	CSMD1_ENST00000542608.1_Missense_Mutation_p.G149E|CSMD1_ENST00000539096.1_Missense_Mutation_p.G149E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G149E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G149E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G149E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G149E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	149	Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGGATTTCTCCAGGATTTCC	0.418000													13	45					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561305	44561305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44561305C>T	ENST00000332567.4	-	1	683	c.331G>A	c.(331-333)Ggc>Agc	p.G111S	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	111					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TCTGGGAAGCCCCAGGCCTTT	0.662000													34	94					0	0	1	0	0
SOX17	64321	broad.mit.edu	37	8	55370910	55370910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55370910C>T	ENST00000297316.4	+	1	416	c.212C>T	c.(211-213)cCg>cTg	p.P71L		NM_022454.3	NP_071899.1	Q9H6I2	SOX17_HUMAN	SRY (sex determining region Y)-box 17	71					angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.P71Q(1)		endometrium(6)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)	18		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			ATCCGGCGGCCGATGAACGCT	0.677000													16	27					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30510708	30510708	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30510708G>A	ENST00000356798.6	+	17	2223	c.2043G>A	c.(2041-2043)cgG>cgA	p.R681R	ITGAL_ENST00000358164.5_Silent_p.R598R|ITGAL_ENST00000433423.2_Silent_p.R77R|RP11-297C4.1_ENST00000563751.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	681					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	ATGGCCACCGGACCAGAAGAC	0.547000													13	163					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307420	140307420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140307420G>A	ENST00000253807.2	+	1	943	c.943G>A	c.(943-945)Gaa>Aaa	p.E315K	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.E315K|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGGGACGAAGGTGTCTT	0.547000													54	133					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807786	20807786	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20807786G>T	ENST00000601440.1	-	4	1043	c.897C>A	c.(895-897)acC>acA	p.T299T	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						GTGTAGTAAGGGTTGAGGACC	0.368000													16	140					6.31663e-08	6.33641e-08	1	1	0
CALN1	83698	broad.mit.edu	37	7	71743780	71743780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:71743780G>A	ENST00000395275.2	-	3	523	c.135C>T	c.(133-135)ttC>ttT	p.F45F	CALN1_ENST00000431984.1_Silent_p.F3F|CALN1_ENST00000412588.1_Silent_p.F45F|CALN1_ENST00000329008.5_Silent_p.F3F|CALN1_ENST00000405452.2_Silent_p.F3F|CALN1_ENST00000395276.2_Silent_p.F3F	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	3	EF-hand 1.					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TCACATGGTGGAACGGCATCT	0.498000													12	47					0	0	1	0	0
PROSER2	254427	broad.mit.edu	37	10	11911718	11911718	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11911718G>A	ENST00000277570.5	+	4	775	c.621G>A	c.(619-621)ggG>ggA	p.G207G	PROSER2-AS1_ENST00000445498.1_RNA|PROSER2_ENST00000379200.1_Silent_p.G11G|PROSER2-AS1_ENST00000453242.1_RNA	NM_153256.3	NP_694988.3			proline and serine-rich protein 2																		GGATGGCGGGGAACGAAGCCC	0.731000													7	6					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57176870	57176870	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:57176870C>T	ENST00000504228.1	+	4	429	c.324C>T	c.(322-324)ctC>ctT	p.L108L	KIAA1211_ENST00000541073.1_Silent_p.L101L|KIAA1211_ENST00000264229.6_Silent_p.L108L|KIAA1211_ENST00000505410.1_3'UTR			Q6ZU35	K1211_HUMAN	KIAA1211	108										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CTCTGAATCTCCCTGGAGCTG	0.423000													27	64					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150416156	150416156	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150416156G>A	ENST00000307194.5	+	2	161	c.21G>A	c.(19-21)gcG>gcA	p.A7A		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAAGATGGCGACAGATGAAG	0.413000													43	94					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56552397	56552397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56552397G>A	ENST00000390649.3	+	11	2896	c.2896G>A	c.(2896-2898)Gaa>Aaa	p.E966K		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	966						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCTGGGGAACGAAGGTGTAAA	0.567000													51	142					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55279591	55279591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55279591G>A	ENST00000358193.3	+	7	921	c.867G>A	c.(865-867)ccG>ccA	p.P289P	C1orf177_ENST00000371273.3_Silent_p.P289P	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	289										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CCCGAAACCCGAAAACCCCTA	0.502000													38	122					0	0	1	0	0
VSTM2L	128434	broad.mit.edu	37	20	36572431	36572431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36572431C>T	ENST00000373461.4	+	4	638	c.391C>T	c.(391-393)Cgg>Tgg	p.R131W	VSTM2L_ENST00000373459.4_Missense_Mutation_p.P57L|VSTM2L_ENST00000373458.3_Missense_Mutation_p.R114W	NM_080607.2	NP_542174.1	Q96N03	VTM2L_HUMAN	V-set and transmembrane domain containing 2 like	131	Ig-like.									central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(1)|skin(1)	8		Myeloproliferative disorder(115;0.00878)				GCGCCTGTCCCGGGTGAAGCC	0.642000													3	25					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60377841	60377841	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60377841C>T	ENST00000371204.3	-	3	559	c.516G>A	c.(514-516)gaG>gaA	p.E172E	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	172					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					CACCGTTCTCCTCTTTTATTG	0.458000													18	31					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502563	140502563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140502563G>A	ENST00000194152.1	+	1	983	c.983G>A	c.(982-984)gGa>gAa	p.G328E		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		328	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCCTTTCTGGAAAAGGCACT	0.418000													95	211					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81699006	81699006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:81699006G>A	ENST00000429644.2	-	4	1139	c.496C>T	c.(496-498)Cgt>Tgt	p.R166C	GBE1_ENST00000489715.1_Missense_Mutation_p.R125C	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	166					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TCACCTTCACGAACCACATAC	0.333000									Glycogen Storage Disease, type IV				14	45					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17488061	17488061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17488061G>A	ENST00000252590.4	-	1	98	c.37C>T	c.(37-39)Cgg>Tgg	p.R13W		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	13						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCCCCCGCCCGAGCGTAGGAC	0.652000													12	126					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887521	9887521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:9887521G>A	ENST00000306084.6	+	2	1244	c.1045G>A	c.(1045-1047)Gaa>Aaa	p.E349K	TXNDC2_ENST00000357775.4_Missense_Mutation_p.E282K|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	349	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						CAAGTCCCCAGAAGAAACCAT	0.562000													68	137					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70998852	70998852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70998852G>A	ENST00000354624.5	+	5	683	c.550G>A	c.(550-552)Gat>Aat	p.D184N	HKDC1_ENST00000395086.2_Missense_Mutation_p.D184N	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	184					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TCAGGACACGGATGTGGTGAG	0.512000													11	40					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78638703	78638703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78638703G>A	ENST00000545128.1	+	4	999	c.461G>A	c.(460-462)gGa>gAa	p.G154E	PCSK5_ENST00000376752.4_Missense_Mutation_p.G154E|PCSK5_ENST00000376767.3_Missense_Mutation_p.G154E	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	154	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						AATATCGAAGGAGCCTGGAAG	0.453000													16	88					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072763	17072763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17072763C>T	ENST00000359963.3	-	1	937	c.678G>A	c.(676-678)ggG>ggA	p.G226G		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	226					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CACAGAGCTTCCCAGATATTG	0.607000													12	97					0	0	1	0	0
TCL1B	9623	broad.mit.edu	37	14	96157628	96157628	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96157628C>T	ENST00000340722.7	+	3	408	c.357C>T	c.(355-357)gtC>gtT	p.V119V	RP11-1070N10.6_ENST00000461160.1_RNA	NM_004918.3	NP_004909.1	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	119										cervix(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		AGCAGCTGGTCCTAACATATC	0.562000													8	23					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430806	37430806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37430806G>A	ENST00000374660.1	+	7	912	c.813G>A	c.(811-813)gaG>gaA	p.E271E	ANKRD30A_ENST00000602533.1_Silent_p.E271E|ANKRD30A_ENST00000361713.1_Silent_p.E271E			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	327						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CACCTGATGAGGCTGCATCCT	0.473000													17	55					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4069536	4069536	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:4069536T>G	ENST00000274673.3	-	7	1324	c.921A>C	c.(919-921)agA>agC	p.R307S	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	307																	TCGTTTGTAGTCTTGGCCTCT	0.433000													40	85					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069466	6069466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:6069466G>A	ENST00000381095.3	-	2	669	c.42C>T	c.(40-42)ttC>ttT	p.F14F	NLGN4X_ENST00000538097.1_Silent_p.F14F|NLGN4X_ENST00000275857.6_Silent_p.F14F|NLGN4X_ENST00000381093.2_Silent_p.F14F|NLGN4X_ENST00000381092.1_Silent_p.F14F|NLGN4X_ENST00000469740.1_5'UTR	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	14					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity	p.F14L(1)		breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						AGACCGGGGTGAACAACAAAG	0.512000													22	21					0	0	1	0	0
NKG7	4818	broad.mit.edu	37	19	51875645	51875645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51875645C>T	ENST00000221978.5	-	1	324	c.145G>A	c.(145-147)Gac>Aac	p.D49N	NKG7_ENST00000600427.1_Missense_Mutation_p.D49N|NKG7_ENST00000595217.1_Missense_Mutation_p.D49N	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	49						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GATATGATGTCCCCATGCCCT	0.582000													52	164					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32366635	32366635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:32366635G>A	ENST00000357033.4	-	38	5542	c.5336C>T	c.(5335-5337)cCt>cTt	p.P1779L	DMD_ENST00000378677.2_Missense_Mutation_p.P1775L	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1779	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTCCTTCAAAGGAATGGAGGC	0.343000													14	9					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73477502	73477502	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73477502C>T	ENST00000252034.7	+	27	2205	c.1806C>T	c.(1804-1806)gtC>gtT	p.V602V	ELN_ENST00000380553.4_Silent_p.V466V|ELN_ENST00000380562.4_Silent_p.V608V|ELN_ENST00000358929.4_Silent_p.V670V|ELN_ENST00000414324.1_Silent_p.V578V|ELN_ENST00000320399.6_Silent_p.V635V|ELN_ENST00000429192.1_Silent_p.V588V|ELN_ENST00000380584.4_Silent_p.V554V|ELN_ENST00000445912.1_Silent_p.V602V|ELN_ENST00000458204.1_Silent_p.V592V|ELN_ENST00000357036.5_Silent_p.V607V|ELN_ENST00000380576.5_Silent_p.V583V|ELN_ENST00000320492.7_Silent_p.V521V|ELN_ENST00000380575.4_Silent_p.V573V	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	664	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGCCTGGGGTCCTTGGAGGGC	0.622000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						8	17					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36349316	36349316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36349316C>T	ENST00000360202.5	+	3	416	c.218C>T	c.(217-219)tCc>tTc	p.S73F	KIRREL2_ENST00000347900.6_Missense_Mutation_p.S23F|KIRREL2_ENST00000592409.1_Missense_Mutation_p.S73F|KIRREL2_ENST00000586102.2_Missense_Mutation_p.S73F|KIRREL2_ENST00000262625.7_Missense_Mutation_p.S73F|NPHS1_ENST00000591817.1_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	73	Ig-like C2-type 1.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCAGGGTGGTCCCGGTACTGG	0.557000													25	56					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69736497	69736497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69736497G>A	ENST00000409085.4	-	14	2248	c.1872C>T	c.(1870-1872)tcC>tcT	p.S624S	AAK1_ENST00000406297.3_Silent_p.S624S|AAK1_ENST00000409068.1_Silent_p.S624S	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	624						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						GGGTTTTGGGGGATGAGGGTG	0.567000													6	61					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358893	72358893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72358893C>T	ENST00000441259.1	-	3	744	c.584G>A	c.(583-585)aGg>aAg	p.R195K	PRF1_ENST00000373209.2_Missense_Mutation_p.R195K	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	195	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						CCCGAGGGCCCTCTTGAAGTC	0.612000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				7	41					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197765482	197765482	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:197765482C>T	ENST00000330198.4	+	16	1934	c.1912C>T	c.(1912-1914)Ctg>Ttg	p.L638L	LMLN_ENST00000482695.1_Silent_p.L623L|LMLN_ENST00000420910.2_Silent_p.L675L|LMLN_ENST00000332636.5_Silent_p.L586L|LMLN-AS1_ENST00000423460.1_RNA	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	638					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CCTCTGGCTTCTGCTAGGCAA	0.393000													25	91					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838960	112838960	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:112838960G>A	ENST00000280155.2	+	1	2171	c.1206G>A	c.(1204-1206)tgG>tgA	p.W402*		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	387					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	TGGTGTGCTGGTTCCCCTTCT	0.632000													27	75					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65489842	65489842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65489842G>A	ENST00000261883.4	-	9	2948	c.2782C>T	c.(2782-2784)Ccc>Tcc	p.P928S		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	928					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix		p.P928T(1)		breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TCGTTGAAGGGGACTGTGTTG	0.522000													25	154					0	0	1	0	0
FGF20	26281	broad.mit.edu	37	8	16850716	16850716	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16850716C>T	ENST00000180166.5	-	3	649	c.501G>A	c.(499-501)gtG>gtA	p.V167V		NM_019851.2	NP_062825.1	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	167					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	11				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		TGTTAAGTGCCACAAAATACC	0.433000													22	177					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56485099	56485099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56485099G>A	ENST00000291971.3	+	7	2687	c.2616G>A	c.(2614-2616)ctG>ctA	p.L872L	NLRP8_ENST00000590542.1_Silent_p.L853L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	872						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TGACCCACCTGAGCTTGGCAG	0.517000													70	175					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100680818	100680818	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100680818G>A	ENST00000306151.4	+	3	6185	c.6121G>A	c.(6121-6123)Gaa>Aaa	p.E2041K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2041	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.E2041K(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAACGGACCAC	0.498000													76	223					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6712527	6712527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6712527C>T	ENST00000245907.6	-	10	1203	c.1111G>A	c.(1111-1113)Gac>Aac	p.D371N		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	371					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACCATGAGGTCAAAGGGCATT	0.632000													30	144					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159680709	159680709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:159680709G>A	ENST00000393977.3	-	7	1269	c.984C>T	c.(982-984)ttC>ttT	p.F328F	CCNJL_ENST00000257536.7_Silent_p.F280F|CCNJL_ENST00000377503.2_5'UTR	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	328						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGGTGGCTGGAACAGCACTT	0.642000													16	44					0	0	1	0	0
CNR2	1269	broad.mit.edu	37	1	24201316	24201316	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24201316G>A	ENST00000536471.1	-	3	1050	c.792C>T	c.(790-792)ctC>ctT	p.L264L	CNR2_ENST00000374472.4_Silent_p.L264L			P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	264					behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	TGTGGGCCATGAGGGCCAGCA	0.577000													8	68					0	0	1	0	0
EXOC7	23265	broad.mit.edu	37	17	74087233	74087233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74087233G>A	ENST00000607838.1	-	7	986	c.892C>T	c.(892-894)Cct>Tct	p.P298S	EXOC7_ENST00000467929.2_Missense_Mutation_p.P257S|EXOC7_ENST00000411744.2_Intron|EXOC7_ENST00000589210.1_Missense_Mutation_p.P298S|EXOC7_ENST00000332065.5_Intron|EXOC7_ENST00000335146.7_Missense_Mutation_p.P298S|EXOC7_ENST00000405575.4_Missense_Mutation_p.P298S	NM_001145297.2|NM_001145298.2|NM_001145299.2	NP_001138769.1|NP_001138770.1|NP_001138771.1	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7	298					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	14			LUSC - Lung squamous cell carcinoma(166;0.187)			CCTTCCAGAGGAATGAGGTTA	0.577000													50	178					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147743900	147743900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:147743900G>A	ENST00000370460.2	+	3	1131	c.652G>A	c.(652-654)Gaa>Aaa	p.E218K	AFF2_ENST00000370457.5_Missense_Mutation_p.E214K|AFF2_ENST00000370458.1_Missense_Mutation_p.E214K|AFF2_ENST00000342251.3_Missense_Mutation_p.E214K	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	218					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding	p.E218K(1)		breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					ATCTGCAAAGGAAGACAGTAA	0.468000													97	53					0	0	1	0	0
CELF4	56853	broad.mit.edu	37	18	34839097	34839097	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:34839097T>C	ENST00000588597.1	-	11	1353	c.1344A>G	c.(1342-1344)caA>caG	p.Q448Q	CELF4_ENST00000412753.1_Intron|CELF4_ENST00000420428.2_Intron|CELF4_ENST00000361795.5_Intron|CELF4_ENST00000603232.1_Intron|CELF4_ENST00000591287.1_Intron|CELF4_ENST00000601019.1_Intron|CELF4_ENST00000334919.5_Intron|CELF4_ENST00000591282.1_Intron			Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	93	RRM 3.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						AGCATTTACTTTGGTTAGTCG	0.507000													12	20					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120740003	120740003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120740003C>T	ENST00000310396.5	+	7	1240	c.773C>T	c.(772-774)cCa>cTa	p.P258L	CPED1_ENST00000450913.2_Missense_Mutation_p.P258L|CPED1_ENST00000423795.1_Missense_Mutation_p.P38L	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		GTCCTTGCTCCACATGAAACA	0.383000													18	76					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156761529	156761529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156761529C>T	ENST00000271526.4	+	4	1396	c.1124C>T	c.(1123-1125)gCc>gTc	p.A375V	PRCC_ENST00000491853.1_3'UTR|PRCC_ENST00000353233.3_Intron	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	375					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGGACCCGGCCCTGGTCCCC	0.537000			T	TFE3	papillary renal								19	84					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18156698	18156698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18156698G>A	ENST00000327031.4	-	9	1155	c.930C>T	c.(928-930)ccC>ccT	p.P310P	FLII_ENST00000379450.4_Silent_p.P225P|FLII_ENST00000584444.1_5'UTR|FLII_ENST00000579294.1_Silent_p.P299P|FLII_ENST00000578558.1_Silent_p.P310P|FLII_ENST00000545457.2_Silent_p.P256P	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	310	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					CAATGCCTGAGGGCAGCCCGT	0.582000													7	48					0	0	1	0	0
MMP7	4316	broad.mit.edu	37	11	102398304	102398304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102398304C>T	ENST00000260227.4	-	3	487	c.435G>A	c.(433-435)agG>agA	p.R145R		NM_002423.3	NP_002414.1	P09237	MMP7_HUMAN	matrix metallopeptidase 7 (matrilysin, uterine)	145					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		ATACAACTTTCCTGAAATGCA	0.443000													43	98					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94137937	94137937	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94137937A>G	ENST00000282020.4	+	6	1096	c.838A>G	c.(838-840)Agg>Ggg	p.R280G	GRID2_ENST00000510992.1_Missense_Mutation_p.R185G|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	280					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GTCAATTGGAAGGTTAACGAT	0.393000													41	169					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125094666	125094666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125094666G>A	ENST00000522917.1	+	33	4564	c.4358G>A	c.(4357-4359)cGa>cAa	p.R1453Q	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.R1453Q	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1453						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AGCAAACACCGAGCCATCTGT	0.498000													70	122					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123036904	123036904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123036904G>A	ENST00000462833.1	-	11	3529	c.2317C>T	c.(2317-2319)Ctc>Ttc	p.L773F	ADCY5_ENST00000491190.1_Missense_Mutation_p.L406F|ADCY5_ENST00000309879.5_Missense_Mutation_p.L423F	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	773					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CAGATGAAGAGGAAGACGAGC	0.597000													7	83					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51380289	51380289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51380289C>T	ENST00000358049.4	+	4	671	c.655C>T	c.(655-657)Ctg>Ttg	p.L219L	KLK2_ENST00000391810.2_Intron|KLK2_ENST00000325321.3_Intron	NM_001002231.2|NM_005551.4	NP_001002231.1|NP_005542.1	P20151	KLK2_HUMAN	kallikrein-related peptidase 2	0	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		CTCCCAACATCTGGAGGGGAA	0.537000			T	ETV4	prostate								28	95					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75107041	75107041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75107041C>T	ENST00000326665.5	-	5	636	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	140										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GAATGTCCTTCATCAACCAGA	0.423000													22	104					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123932070	123932070	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123932070G>A	ENST00000373855.1	+	39	6512	c.6252G>A	c.(6250-6252)cgG>cgA	p.R2084R	CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000373850.1_Silent_p.R1532R|CNTRL_ENST00000238341.5_Silent_p.R2084R			Q7Z7A1	CNTRL_HUMAN	centriolin	2084	Required for centrosome localization.|Sufficient for interaction with HOOK2.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						AGATCCAGCGGAGCCAGCTGG	0.468000													28	69					0	0	1	0	0
C15orf48	84419	broad.mit.edu	37	15	45724270	45724270	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45724270C>T	ENST00000344300.3	+	3	313	c.122_splice	c.e3-1	p.I41_splice	C15orf48_ENST00000396650.2_Splice_Site_p.I41_splice|RP11-519G16.5_ENST00000559553.1_RNA	NM_032413.3	NP_115789.1	Q9C002	NMES1_HUMAN	chromosome 15 open reading frame 48	41						nucleus				large_intestine(1)|lung(2)|ovary(1)	4		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.67e-16)|GBM - Glioblastoma multiforme(94;1.71e-06)		TTAATTTTAGCCTTGATCGAA	0.318000													8	36					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48565299	48565299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48565299G>A	ENST00000354276.3	-	14	1540	c.1213C>T	c.(1213-1215)Cac>Tac	p.H405Y	PLA2G4C_ENST00000599921.1_Missense_Mutation_p.H405Y|PLA2G4C_ENST00000599111.1_Missense_Mutation_p.H415Y|CTD-2265M8.2_ENST00000601548.1_RNA|CTD-2265M8.2_ENST00000596552.1_RNA|PLA2G4C_ENST00000413144.2_Missense_Mutation_p.H405Y|CTD-2265M8.2_ENST00000601950.1_RNA|PLA2G4C_ENST00000596510.1_5'UTR	NM_001159323.1	NP_001152795.1	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	405	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		AGGATGAGGTGAACCTCCCGC	0.612000													34	103					0	0	1	0	0
USP41	373856	broad.mit.edu	37	22	20729881	20729881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20729881G>A	ENST00000454608.2	-	6	298	c.299C>T	c.(298-300)cCt>cTt	p.P100L						ubiquitin specific peptidase 41											endometrium(1)|kidney(1)|lung(2)|skin(1)	5						CATCTGGAAAGGGACGCTTCT	0.577000													5	19					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87027688	87027688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:87027688G>A	ENST00000398399.2	-	2	754	c.391C>T	c.(391-393)Ccc>Tcc	p.P131S	VGLL3_ENST00000383698.3_Missense_Mutation_p.P131S	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CGCCATAGGGGGGTTAGCCCC	0.507000													41	93					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183673094	183673094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183673094C>T	ENST00000511685.1	+	20	3894	c.3771C>T	c.(3769-3771)gtC>gtT	p.V1257V	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Silent_p.V1257V					teneurin transmembrane protein 3																		CAGAAGTCGTCGCAGGGACAG	0.537000													17	48					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111887485	111887485	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111887485G>A	ENST00000440460.2	+	19	2121	c.1824G>A	c.(1822-1824)cgG>cgA	p.R608R	DIXDC1_ENST00000315253.5_Silent_p.R397R|DIXDC1_ENST00000389821.4_3'UTR	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	609	DIX.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		TCACTGACCGGTCACTTACGC	0.438000													6	8					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095473	167095473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167095473G>A	ENST00000361200.2	+	6	1271	c.1105G>A	c.(1105-1107)Gga>Aga	p.G369R	DUSP27_ENST00000271385.5_Missense_Mutation_p.G369R|DUSP27_ENST00000443333.1_Missense_Mutation_p.G369R|DUSP27_ENST00000485151.1_3'UTR			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	369					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCCCCAGGATGGAGGTGGCTG	0.632000													3	6					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770916	53770916	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53770916C>T	ENST00000311170.4	-	1	56	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	1					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		ACCGGGAGGCCATTCTGCCAC	0.507000										HNSCC(26;0.072)			20	54					0	0	1	0	0
WDR37	22884	broad.mit.edu	37	10	1149546	1149546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:1149546C>T	ENST00000358220.1	+	10	875	c.731C>T	c.(730-732)tCt>tTt	p.S244F	WDR37_ENST00000263150.4_Missense_Mutation_p.S244F			Q9Y2I8	WDR37_HUMAN	WD repeat domain 37	244										breast(2)|endometrium(2)|kidney(1)|lung(9)|prostate(2)|skin(1)	17		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		CAGCAGATATCTGGGGAAGAT	0.498000													13	38					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130187862	130187862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130187862C>T	ENST00000265379.6	+	38	7508	c.7014C>T	c.(7012-7014)gtC>gtT	p.V2338V	COL6A5_ENST00000432398.2_Silent_p.V2338V			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	2338	Nonhelical region.|VWFA 10.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						GGGTTGCTGTCCTGAGCTACT	0.428000													10	30					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11971966	11971966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:11971966C>T	ENST00000339865.5	+	23	4079	c.3316C>T	c.(3316-3318)Cat>Tat	p.H1106Y	USP47_ENST00000539466.1_5'UTR|USP47_ENST00000399455.2_Missense_Mutation_p.H1194Y|USP47_ENST00000527733.1_Missense_Mutation_p.H1174Y	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	1194					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		TTTGGATTATCATATTTATGA	0.323000													39	106					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20648554	20648554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20648554G>A	ENST00000219151.4	-	9	1268	c.58C>T	c.(58-60)Cat>Tat	p.H20Y	ACSM1_ENST00000520010.1_Intron|ACSM1_ENST00000307493.4_Intron			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	399					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						GCCTCCATATGAAACTGAAGG	0.507000													22	78					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176809404	176809404	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176809404G>A	ENST00000367662.3	+	22	6462	c.5298G>A	c.(5296-5298)aaG>aaA	p.K1766K		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1766					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TCTCCTCCAAGAAGGTGAGTG	0.522000													25	91					0	0	1	0	0
PRMT3	10196	broad.mit.edu	37	11	20483679	20483679	+	Missense_Mutation	SNP	C	C	T	rs142036289		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20483679C>T	ENST00000331079.6	+	12	1443	c.1226C>T	c.(1225-1227)cCg>cTg	p.P409L	PRMT3_ENST00000437750.2_Missense_Mutation_p.P347L	NM_001145167.1|NM_005788.3	NP_001138639.1|NP_005779.1	O60678	ANM3_HUMAN	protein arginine methyltransferase 3	409							zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|prostate(1)	17						GTTTTAGATCCGAAGACTCTT	0.348000													69	174					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10132199	10132199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:10132199C>T	ENST00000324907.9	+	11	1522	c.1386C>T	c.(1384-1386)ccC>ccT	p.P462P	GRHL1_ENST00000324883.5_Silent_p.P273P|GRHL1_ENST00000405379.2_Silent_p.P462P	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	462					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TTTTCAAACCCTTCATTGATC	0.448000													30	28					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13692204	13692204	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13692204C>T	ENST00000265104.4	-	79	13868	c.13764G>A	c.(13762-13764)aaG>aaA	p.K4588K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4588					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GAACTGGCTTCTTATAGATGG	0.478000									Kartagener syndrome				29	73					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55566682	55566682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55566682G>A	ENST00000373965.2	-	36	5106	c.4712C>T	c.(4711-4713)tCc>tTc	p.S1571F	PCDH15_ENST00000414778.1_Missense_Mutation_p.S1568F	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	422					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCGAACAGGGGAAGCAACTTT	0.458000										HNSCC(58;0.16)			39	175					0	0	1	0	0
AMOTL2	51421	broad.mit.edu	37	3	134085246	134085246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134085246G>A	ENST00000514516.1	-	4	1417	c.1239C>T	c.(1237-1239)ctC>ctT	p.L413L	AMOTL2_ENST00000249883.5_Silent_p.L355L|AMOTL2_ENST00000422605.2_Silent_p.L355L|AMOTL2_ENST00000513145.1_Silent_p.L355L	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	355										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						GGGCCTCAGAGAGCCGCTGGA	0.577000													8	102					0	0	1	0	0
DEGS2	123099	broad.mit.edu	37	14	100615658	100615658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100615658G>A	ENST00000305631.5	-	2	1047	c.472C>T	c.(472-474)Cgc>Tgc	p.R158C	DEGS2_ENST00000557117.1_5'UTR|DEGS2_ENST00000553834.1_Intron	NM_206918.2	NP_996801.2	Q6QHC5	DEGS2_HUMAN	delta(4)-desaturase, sphingolipid 2	158					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity			breast(1)|lung(6)|skin(1)	8		Melanoma(154;0.212)				AGCAGCTTGCGGGCGGGTGTG	0.662000													17	35					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30018572	30018572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30018572C>T	ENST00000350119.4	-	6	766	c.576G>A	c.(574-576)ggG>ggA	p.G192G	DOC2A_ENST00000564979.1_Silent_p.G192G|DOC2A_ENST00000564944.1_Silent_p.G192G	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	192	C2 1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						CGCGGATCTCCCCAATAAACT	0.622000													32	62					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58583660	58583660	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58583660T>G	ENST00000317147.5	-	25	3817	c.3485A>C	c.(3484-3486)aAc>aCc	p.N1162T	CNOT1_ENST00000441024.2_Missense_Mutation_p.N1162T|CNOT1_ENST00000245138.4_Missense_Mutation_p.N52T|CNOT1_ENST00000569240.1_Missense_Mutation_p.N1157T	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1162					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AACCATCTTGTTAAATTCAGG	0.328000													39	108					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17038904	17038904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17038904C>T	ENST00000443236.1	-	25	3457	c.3426G>A	c.(3424-3426)gtG>gtA	p.V1142V		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1095						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						AGCTCTCGTCCACCTCCATCT	0.642000													24	62					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25670448	25670448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25670448C>T	ENST00000281589.3	+	1	149	c.112C>T	c.(112-114)Ctc>Ttc	p.L38F		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	38	RRM 1.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AGGGCCCATCCTCTCCATCCG	0.622000													29	75					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6386953	6386953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6386953G>A	ENST00000262483.8	-	6	558	c.471C>T	c.(469-471)ttC>ttT	p.F157F	ACKR6_ENST00000421306.3_Silent_p.F121F	NM_031220.3	NP_112497.2																					GCACGGAGCTGAAGGTGTGGA	0.617000													16	30					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072451	17072451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17072451C>T	ENST00000359963.3	-	1	1249	c.990G>A	c.(988-990)ttG>ttA	p.L330L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	330					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GAGGTGTGTCCAACACCTCAC	0.567000													48	146					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141108493	141108493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141108493C>T	ENST00000389484.3	-	77	12736	c.11765G>A	c.(11764-11766)aGa>aAa	p.R3922K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3922					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.R3922I(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCTGTTATTCTTGAATTATG	0.343000										TSP Lung(27;0.18)			15	146					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56128269	56128269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56128269C>T	ENST00000303039.3	+	1	579	c.547C>T	c.(547-549)Cct>Tct	p.P183S		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					TGATAATGTTCCTCTGTTAGC	0.338000													24	54					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56511255	56511255	+	Silent	SNP	G	G	A	rs61735257	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56511255G>A	ENST00000302957.3	-	1	32	c.33C>T	c.(31-33)ttC>ttT	p.F11F		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CCACGGAGGTGAAAGCCTGAC	0.413000													35	98					0	0	1	0	0
MAP4K3	8491	broad.mit.edu	37	2	39515267	39515267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:39515267G>A	ENST00000263881.3	-	20	1793	c.1469C>T	c.(1468-1470)gCc>gTc	p.A490V	MAP4K3_ENST00000341681.5_Missense_Mutation_p.A469V|MAP4K3_ENST00000536018.1_Missense_Mutation_p.A43V|MAP4K3_ENST00000437545.1_Missense_Mutation_p.A406V	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	490					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				ATTACCTAAGGCAACAGGTTT	0.438000													58	138					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23775187	23775187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23775187G>A	ENST00000354639.3	+	7	909	c.445G>A	c.(445-447)Gaa>Aaa	p.E149K	STK31_ENST00000433467.2_Missense_Mutation_p.E172K|STK31_ENST00000355870.3_Missense_Mutation_p.E172K|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Missense_Mutation_p.E149K	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	172							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CTTGATTTTTGAAAAGGAAAT	0.388000													40	102					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282509	69282509	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69282509C>T	ENST00000338352.2	+	1	169	c.135C>T	c.(133-135)ctC>ctT	p.L45L		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	45										autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						AGCAGTTGCTCCAAGACGTGG	0.582000													5	7					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130509543	130509543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130509543G>A	ENST00000314830.8	-	6	1260	c.1147C>T	c.(1147-1149)Ctg>Ttg	p.L383L	SH2D3C_ENST00000429553.1_Silent_p.L29L|SH2D3C_ENST00000373274.3_Silent_p.L223L|SH2D3C_ENST00000420366.1_Silent_p.L225L|SH2D3C_ENST00000471939.1_Intron|SH2D3C_ENST00000373277.4_Silent_p.L226L|SH2D3C_ENST00000373276.3_Silent_p.L315L	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	383					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GGGCGGGGCAGCGACGTACTG	0.657000													8	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179447116	179447116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179447116C>T	ENST00000589042.1	-	314	66291	c.66067G>A	c.(66067-66069)Ggc>Agc	p.G22023S	TTN_ENST00000342992.6_Missense_Mutation_p.G19455S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G12958S|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G13150S|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G13083S|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G20382S|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20382	Ig-like 115.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTCATGGCCCTCTATAAGT	0.453000													19	44					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18250623	18250623	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:18250623G>C	ENST00000377369.2	+	3	648	c.375G>C	c.(373-375)caG>caC	p.Q125H	SLC39A12_ENST00000377374.4_Missense_Mutation_p.Q125H|SLC39A12_ENST00000377371.3_Missense_Mutation_p.Q125H|SLC39A12_ENST00000539911.1_5'UTR	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	125					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						TTATTCATCAGGAAGAGATCT	0.383000													28	70					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440305	40440305	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40440305C>T	ENST00000319592.4	-	4	1315	c.606G>A	c.(604-606)gaG>gaA	p.E202E	RBM47_ENST00000381793.2_Silent_p.E202E|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381795.6_Silent_p.E202E|RBM47_ENST00000514014.1_Silent_p.E164E|RBM47_ENST00000295971.7_Silent_p.E202E			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	202	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CGCGGTGGCTCTCGTACTCCA	0.662000													17	64					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301413	11301413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11301413C>T	ENST00000397056.1	+	3	881	c.690C>T	c.(688-690)tcC>tcT	p.S230S	HRH1_ENST00000431010.2_Silent_p.S230S|HRH1_ENST00000438284.2_Silent_p.S230S	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	230					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TCAATAGGTCCCTCCCTTCCT	0.537000													32	61					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240635690	240635690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240635690G>A	ENST00000319653.9	+	17	5309	c.5079G>A	c.(5077-5079)gaG>gaA	p.E1693E	AL646016.1_ENST00000596886.1_Intron|FMN2_ENST00000545751.1_Silent_p.E289E|FMN2_ENST00000543681.1_Silent_p.E13E|FMN2_ENST00000496950.1_3'UTR	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1693	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAGCCGAAGAGGTGTGTAGAC	0.333000													27	74					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163027502	163027502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163027502G>A	ENST00000188790.4	-	26	2477	c.2270C>T	c.(2269-2271)tCt>tTt	p.S757F	FAP_ENST00000443424.1_Missense_Mutation_p.S732F|AC007750.5_ENST00000418968.2_RNA	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	757					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						GTCTGACAAAGAGAAACACTG	0.413000													15	149					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110464387	110464387	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110464387G>A	ENST00000378402.5	+	42	6489	c.6385G>A	c.(6385-6387)Gaa>Aaa	p.E2129K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2129	IPT/TIG 14.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CACCATAGCTGAAGCCAAATG	0.398000										HNSCC(38;0.096)			20	28					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	121960374	121960374	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121960374G>A	ENST00000334010.7	-	28	4151	c.3730C>T	c.(3730-3732)Cga>Tga	p.R1244*	CADPS2_ENST00000449022.2_Nonsense_Mutation_p.R1246*|CADPS2_ENST00000313070.7_Nonsense_Mutation_p.R1205*|CADPS2_ENST00000412584.2_Nonsense_Mutation_p.R1205*	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	1246					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding	p.R1243*(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						CCCTGCAATCGAAAGTCCCTG	0.398000													57	144					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117403125	117403125	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117403125G>A	ENST00000321322.6	-	4	805	c.804C>T	c.(802-804)acC>acT	p.T268T	DSCAML1_ENST00000527706.1_Intron	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	208	Ig-like C2-type 3.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGCTCTGCCGGGTCTCCCCGC	0.612000													9	77					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61232797	61232797	+	Silent	SNP	C	C	T	rs143516663		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61232797C>T	ENST00000382768.1	+	6	825	c.825C>T	c.(823-825)ttC>ttT	p.F275F	SERPINB12_ENST00000269491.1_Silent_p.F255F			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	255					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TCAGCATGTTCGTGCTGCTGC	0.428000													12	105					0	0	1	0	0
PHGDH	26227	broad.mit.edu	37	1	120279789	120279789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120279789C>T	ENST00000369407.3	+	7	2250	c.743C>T	c.(742-744)cCc>cTc	p.P248L	PHGDH_ENST00000369409.4_Missense_Mutation_p.P282L			O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	282					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	18	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	ATCAGCTGTCCCCACCTGGGT	0.592000													16	35					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29194912	29194912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:29194912G>A	ENST00000240100.2	-	4	1205	c.816C>T	c.(814-816)tgC>tgT	p.C272C	DUSP4_ENST00000240101.2_Silent_p.C181C	NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	272	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		CGCGCCCACGGCAGTCCTTCA	0.667000													21	74					0	0	1	0	0
MISP	126353	broad.mit.edu	37	19	757886	757886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:757886C>T	ENST00000215582.6	+	2	1043	c.940C>T	c.(940-942)Cgg>Tgg	p.R314W		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GAGGGGGCTTCGGCAGGCAAC	0.687000													15	24					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238296801	238296801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238296801G>A	ENST00000295550.4	-	4	1188	c.736C>T	c.(736-738)Ctt>Ttt	p.L246F	COL6A3_ENST00000392004.3_Missense_Mutation_p.L40F|COL6A3_ENST00000409809.1_Missense_Mutation_p.L40F|COL6A3_ENST00000392003.2_Intron|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000346358.4_Missense_Mutation_p.L246F|COL6A3_ENST00000353578.4_Missense_Mutation_p.L40F|COL6A3_ENST00000347401.3_Intron	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	246	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCATCAATAAGGAAAATAATG	0.378000													21	73					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52941923	52941923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52941923C>T	ENST00000332323.6	+	4	1310	c.1249C>T	c.(1249-1251)Cat>Tat	p.H417Y	ZNF534_ENST00000433050.1_Missense_Mutation_p.H404Y|ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000432303.2_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						TAGGAAAATTCATACTGGGGG	0.428000													3	6					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345124	20345124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20345124C>T	ENST00000298642.2	+	1	734	c.698C>T	c.(697-699)tCa>tTa	p.S233L		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCCAGAGGATCATCTAAGGCC	0.388000													54	141					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8151201	8151201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8151201C>T	ENST00000600128.1	-	55	7177	c.6763G>A	c.(6763-6765)Gaa>Aaa	p.E2255K	FBN3_ENST00000601739.1_Missense_Mutation_p.E2255K|FBN3_ENST00000270509.2_Missense_Mutation_p.E2255K			Q75N90	FBN3_HUMAN	fibrillin 3	2255	EGF-like 37; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GCGTGGCATTCATTGTCATCT	0.652000													49	114					0	0	1	0	0
NDRG1	10397	broad.mit.edu	37	8	134261013	134261013	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134261013G>A	ENST00000414097.2	-	11	1567	c.698_splice	c.e11-1	p.R234_splice	NDRG1_ENST00000521414.1_5'UTR|NDRG1_ENST00000518176.1_Intron|NDRG1_ENST00000323851.7_Splice_Site_p.R234_splice|NDRG1_ENST00000354944.5_Splice_Site_p.R164_splice|NDRG1_ENST00000537882.1_Splice_Site_p.R153_splice|NDRG1_ENST00000518066.1_Intron|NDRG1_ENST00000522476.1_Splice_Site_p.R168_splice	NM_001135242.1	NP_001128714.1	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	234					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding		NDRG1/ERG(5)	endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(4)|prostate(1)|skin(1)	17	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			AGGTCGCGCCGGCTGCAGGAA	0.607000			T	ERG	prostate								11	100					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101606018	101606018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101606018G>A	ENST00000284395.5	+	33	5767	c.5367G>A	c.(5365-5367)ttG>ttA	p.L1789L	LRRK1_ENST00000532145.1_3'UTR|LRRK1_ENST00000388948.3_Silent_p.L1792L|RP11-505E24.2_ENST00000559857.1_RNA			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1792					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGCGGCCCTTGGACACGGAAC	0.642000													9	49					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33067568	33067568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33067568C>T	ENST00000374864.4	+	18	2005	c.1792C>T	c.(1792-1794)Cgt>Tgt	p.R598C	ITCH_ENST00000483727.1_3'UTR|ITCH_ENST00000535650.1_Missense_Mutation_p.R488C|ITCH_ENST00000262650.6_Missense_Mutation_p.R639C	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	639	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						GAAATATTTTCGTTTTATTGG	0.373000													9	99					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118764606	118764606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118764606G>A	ENST00000292174.4	+	2	529	c.353G>A	c.(352-354)gGg>gAg	p.G118E	BCL9L_ENST00000334801.3_3'UTR	NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	118					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TGGGTCCTGGGGACCTTCCTC	0.617000													26	57					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52282107	52282107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52282107G>A	ENST00000301190.6	+	1	364	c.137G>A	c.(136-138)cGa>cAa	p.R46Q	ANKRD33_ENST00000538991.1_5'UTR|ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_5'UTR	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	0										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GATACCCTACGAACCCCAAGT	0.592000													18	44					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116548868	116548868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:116548868C>T	ENST00000410059.1	+	19	2116	c.1636C>T	c.(1636-1638)Cct>Tct	p.P546S	DPP10_ENST00000409163.1_Missense_Mutation_p.P496S|DPP10_ENST00000393147.2_Missense_Mutation_p.P550S|DPP10_ENST00000310323.8_Missense_Mutation_p.P539S	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	546					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AAAAGAACTTCCTTTACAGTT	0.313000													43	104					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50383659	50383659	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50383659G>A	ENST00000221543.5	+	4	618	c.319_splice	c.e4+1	p.G107_splice	TBC1D17_ENST00000535102.2_Splice_Site_p.G74_splice|TBC1D17_ENST00000598789.1_3'UTR	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	107						intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GCCCACGAGAGGTAGGCTGAG	0.597000													18	32					0	0	1	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31488639	31488639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31488639C>T	ENST00000394863.3	+	11	1258	c.1128C>T	c.(1126-1128)ttC>ttT	p.F376F	TGFB1I1_ENST00000567607.1_Silent_p.F359F|TGFB1I1_ENST00000361773.3_Silent_p.F359F|TGFB1I1_ENST00000394858.2_Silent_p.F359F	NM_001042454.2	NP_001035919.1	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced transcript 1	376	LIM zinc-binding 3.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding	p.F376F(1)|p.F359F(1)		lung(8)|upper_aerodigestive_tract(1)	9						AGGAATGCTTCGCGCCCTTCT	0.662000													18	28					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493984	55493984	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55493984G>A	ENST00000543010.1	+	6	1061	c.918G>A	c.(916-918)ggG>ggA	p.G306G	NLRP2_ENST00000263437.6_Silent_p.G303G|NLRP2_ENST00000537859.1_Silent_p.G284G|NLRP2_ENST00000391721.4_Silent_p.G282G|NLRP2_ENST00000448584.2_Silent_p.G306G|NLRP2_ENST00000339757.7_Silent_p.G284G|NLRP2_ENST00000538819.1_Silent_p.G282G|NLRP2_ENST00000427260.2_Silent_p.G283G	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	306	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ACATCTGCGGGGACTGGGAGA	0.612000													25	53					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	981129	981129	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:981129C>T	ENST00000379370.2	+	15	2603	c.2553C>T	c.(2551-2553)ccC>ccT	p.P851P		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	851	Laminin EGF-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GCTGTGATCCCCAAGGCGCCG	0.657000													27	81					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32126220	32126220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32126220C>T	ENST00000373672.3	-	62	4361	c.3845G>A	c.(3844-3846)gGa>gAa	p.G1282E	COL16A1_ENST00000271069.6_Missense_Mutation_p.G1282E	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1282	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TCCCTGGGGTCCCATGGCACC	0.557000													25	88					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	168004397	168004397	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:168004397C>T	ENST00000357154.3	-	3	327	c.189_splice	c.e3-1	p.E64_splice	SPOCK3_ENST00000502330.1_Intron|SPOCK3_ENST00000511269.1_Intron|SPOCK3_ENST00000421836.2_Intron|SPOCK3_ENST00000534949.1_Intron|SPOCK3_ENST00000507137.1_Intron|SPOCK3_ENST00000357545.4_Intron|SPOCK3_ENST00000512648.1_Intron|SPOCK3_ENST00000512681.1_Intron|SPOCK3_ENST00000535728.1_Intron|SPOCK3_ENST00000541354.1_Intron|SPOCK3_ENST00000511531.1_Intron|SPOCK3_ENST00000541637.1_Intron|SPOCK3_ENST00000506886.1_Splice_Site_p.E64_splice|SPOCK3_ENST00000504953.1_Intron|SPOCK3_ENST00000510741.1_Intron	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	64					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		acctctacttcctcagacttt	0.468000													107	238					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24125836	24125836	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24125836G>A	ENST00000598975.1	-	1	309	c.310C>T	c.(310-312)Cag>Tag	p.Q104*	MMP11_ENST00000215743.3_3'UTR																							GCATGGGACTGAGCCCATGTC	0.632000													8	27					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174649	207174649	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207174649G>A	ENST00000374423.3	+	5	5783	c.5397G>A	c.(5395-5397)agG>agA	p.R1799R		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1799							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ATTCTGTAAGGAACCTGAAAA	0.408000													7	53					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7683931	7683931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7683931C>T	ENST00000256861.6	-	3	336	c.258G>A	c.(256-258)caG>caA	p.Q86Q	ITIH5_ENST00000397146.2_Silent_p.Q86Q|ITIH5_ENST00000446830.2_5'UTR|ITIH5_ENST00000397145.2_Silent_p.Q86Q	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	86	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						GAATCTGCATCTGGAACTCAA	0.483000													45	84					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943525	72943525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72943525G>A	ENST00000328801.4	+	6	1575	c.1575G>A	c.(1573-1575)agG>agA	p.R525R		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	525						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					GGAAGCGGAGGGCACTCAAGG	0.617000													15	44					0	0	1	0	0
GABRR1	2569	broad.mit.edu	37	6	89888625	89888625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:89888625G>A	ENST00000435811.1	-	9	1707	c.1253C>T	c.(1252-1254)tCc>tTc	p.S418F	GABRR1_ENST00000454853.2_Missense_Mutation_p.S435F|GABRR1_ENST00000369451.3_Missense_Mutation_p.S348F	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	435					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	CCTCTGTGGGGAGCTCCTCTC	0.512000													44	66					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124593205	124593205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124593205C>T	ENST00000368904.1	-	10	2583	c.1634G>A	c.(1633-1635)aGt>aAt	p.S545N	CUZD1_ENST00000545804.1_Missense_Mutation_p.S545N|CUZD1_ENST00000392790.1_Missense_Mutation_p.S545N			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	545					cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GCCACTTGCACTTCGATCCCT	0.393000													43	115					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241689931	241689931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241689931G>A	ENST00000498729.2	-	28	3138	c.2892C>T	c.(2890-2892)ccC>ccT	p.P964P	KIF1A_ENST00000320389.7_Silent_p.P863P	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	863					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CCAGGGGAACGGGGTACAGCA	0.657000													7	36					0	0	1	0	0
KCNG3	170850	broad.mit.edu	37	2	42720426	42720426	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:42720426G>A	ENST00000306078.1	-	1	811	c.216C>T	c.(214-216)ttC>ttT	p.F72F	KCNG3_ENST00000394973.4_Silent_p.F72F	NM_133329.5|NM_172344.2	NP_579875.1|NP_758847.1	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G, member 3	72						endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	6						AGAGCAGGATGAAGCCGAAGG	0.662000													13	25					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75065531	75065531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75065531C>T	ENST00000326665.5	-	11	1792	c.1574G>A	c.(1573-1575)gGa>gAa	p.G525E	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.G328E	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	525	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTGCGGTATTCCATTCATTTG	0.388000													61	167					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32996178	32996178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32996178G>A	ENST00000070846.6	-	6	1472	c.1448C>T	c.(1447-1449)aCt>aTt	p.T483I	PKP2_ENST00000340811.4_Intron	NM_004572.3	NP_004563.2	Q99959	PKP2_HUMAN	plakophilin 2	483					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					gcctcccaaagtgctgggatt	0.512000													14	13					0	0	1	0	0
KRTAP9-4	85280	broad.mit.edu	37	17	39406380	39406380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39406380G>A	ENST00000334109.2	+	1	442	c.408G>A	c.(406-408)gaG>gaA	p.E136E		NM_033191.2	NP_149461.2	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	136	15 X 5 AA repeats of C-C-[RQVGE]-[SPTN]- [TASPF].					keratin filament				breast(1)|large_intestine(1)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCTGCTGTGAGACCACTTGCT	0.572000													75	83					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58598337	58598337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58598337C>T	ENST00000240727.6	-	5	1080	c.681G>A	c.(679-681)ggG>ggA	p.G227G	ZSCAN18_ENST00000421612.2_Silent_p.G92G|ZSCAN18_ENST00000601144.1_Silent_p.G227G|ZSCAN18_ENST00000600404.1_Silent_p.G283G	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	227					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCCCCACTCCCCCAGGTGCT	0.642000													10	48					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21069026	21069026	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21069026C>T	ENST00000381545.3	+	16	2173	c.1954C>T	c.(1954-1956)Caa>Taa	p.Q652*	SLCO1B3_ENST00000261196.2_Nonsense_Mutation_p.Q652*|LST3_ENST00000540229.1_Intron|SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	652					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					GAAAAAATTTCAAGGAAAAGA	0.333000													17	33					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100127991	100127991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:100127991C>T	ENST00000395996.1	+	7	937	c.826C>T	c.(826-828)Cgt>Tgt	p.R276C	VPS13B_ENST00000355155.1_Missense_Mutation_p.R276C|VPS13B_ENST00000358544.2_Missense_Mutation_p.R276C|VPS13B_ENST00000357162.2_Missense_Mutation_p.R276C|VPS13B_ENST00000441350.2_Missense_Mutation_p.R276C			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	276					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TATGTTTATTCGTATAATGCA	0.333000													10	93					0	0	1	0	0
IGSF11	152404	broad.mit.edu	37	3	118824028	118824028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:118824028C>T	ENST00000354673.2	-	3	392	c.12G>A	c.(10-12)gtG>gtA	p.V4V	IGSF11_ENST00000425327.2_Silent_p.V4V|IGSF11_ENST00000441144.2_Silent_p.V4V	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	0					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GCAAAAGTTCCACCAGAGACA	0.348000													14	78					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40231732	40231732	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:40231732G>A	ENST00000302541.6	+	10	1785	c.1443G>A	c.(1441-1443)agG>agA	p.R481R	MYRIP_ENST00000539167.1_Silent_p.R294R|MYRIP_ENST00000444716.1_Silent_p.R481R|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Silent_p.R392R|MYRIP_ENST00000425621.1_Silent_p.R481R	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	481	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		AGGCCCCCAGGAACCCTGCAG	0.632000													27	87					0	0	1	0	0
DHRS7C	201140	broad.mit.edu	37	17	9674963	9674963	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:9674963C>T	ENST00000330255.4	-	6	793	c.781G>A	c.(781-783)Gag>Aag	p.E261K	DHRS7C_ENST00000571134.1_Missense_Mutation_p.E260K	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	261						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						CGCATCACCTCCTCCGCCACC	0.622000													11	10					0	0	1	0	0
CALU	813	broad.mit.edu	37	7	128388731	128388731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128388731C>T	ENST00000535623.1	+	3	1061	c.118C>T	c.(118-120)Cct>Tct	p.P40S	CALU_ENST00000479257.1_Missense_Mutation_p.P40S|CALU_ENST00000542996.2_Missense_Mutation_p.P40S|CALU_ENST00000535011.2_Missense_Mutation_p.P32S|CALU_ENST00000249364.4_Missense_Mutation_p.P32S|CALU_ENST00000538546.1_Intron|CALU_ENST00000449187.2_Missense_Mutation_p.P32S	NM_001199671.1	NP_001186600.1	O43852	CALU_HUMAN	calumenin	32					platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding			kidney(2)|large_intestine(3)|lung(5)	10						ACATCATGAGCCTCAGCTCAG	0.468000													37	82					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170940958	170940958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:170940958C>T	ENST00000367759.4	+	8	704	c.550C>T	c.(550-552)Ccc>Tcc	p.P184S	MROH9_ENST00000367758.3_Missense_Mutation_p.P184S	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		CCATGAAGATCCCTCGATTGT	0.438000													81	223					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16908680	16908680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16908680C>T	ENST00000524140.2	+	16	3860	c.3442C>T	c.(3442-3444)Ctt>Ttt	p.L1148F	NWD1_ENST00000523826.1_Missense_Mutation_p.L942F|NWD1_ENST00000379808.3_Missense_Mutation_p.L1148F|NWD1_ENST00000339803.6_Missense_Mutation_p.L1013F|NWD1_ENST00000552788.1_Missense_Mutation_p.L1148F|NWD1_ENST00000549814.1_Missense_Mutation_p.L1148F	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1148							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CACGGGGTCCCTTGATGCGCT	0.517000													66	231					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29122786	29122786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29122786G>A	ENST00000261590.8	+	14	2514	c.2305G>A	c.(2305-2307)Gaa>Aaa	p.E769K	RP11-75N4.2_ENST00000583706.1_RNA	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	769					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TGCACTGAACGAAGAATTCTT	0.478000													23	72					0	0	1	0	0
FBXL15	79176	broad.mit.edu	37	10	104182012	104182012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104182012C>T	ENST00000224862.3	+	3	1992	c.676C>T	c.(676-678)Ctc>Ttc	p.L226F	FBXL15_ENST00000369956.2_Missense_Mutation_p.L222F	NM_024326.3	NP_077302.3	Q9H469	FXL15_HUMAN	F-box and leucine-rich repeat protein 15	226	Interaction with SMURF1.				bone mineralization|dorsal/ventral pattern formation|G2/M transition of mitotic cell cycle|positive regulation of BMP signaling pathway|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding			kidney(1)	1		Colorectal(252;0.207)		Epithelial(162;1.19e-08)|all cancers(201;2.65e-07)		CCACCTTGACCTCACCGGCTG	0.672000													3	13					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71909718	71909718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71909718C>T	ENST00000258104.3	+	54	6392	c.6115C>T	c.(6115-6117)Ctg>Ttg	p.L2039L	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Silent_p.L2040L|DYSF_ENST00000409744.1_Silent_p.L2047L|DYSF_ENST00000410020.3_Silent_p.L2078L|DYSF_ENST00000413539.2_Silent_p.L2070L|DYSF_ENST00000429174.2_Silent_p.L2060L|DYSF_ENST00000409366.1_Silent_p.L2061L|DYSF_ENST00000409582.3_Silent_p.L2077L|DYSF_ENST00000409762.1_Silent_p.L2056L|DYSF_ENST00000409651.1_Silent_p.L2071L|DYSF_ENST00000410041.1_Silent_p.L2057L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	2039						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GAAGTTCATCCTGTGGCGGCG	0.572000													43	91					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780368	37780368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37780368G>A	ENST00000447769.1	+	4	662	c.373G>A	c.(373-375)Gaa>Aaa	p.E125K	EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000461610.1_Intron|GPR141_ENST00000334425.1_Missense_Mutation_p.E125K			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	125						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						AGACAAAGTGGAATTCTACAG	0.498000													35	144					0	0	1	0	0
CBX8	57332	broad.mit.edu	37	17	77769234	77769234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:77769234G>A	ENST00000269385.4	-	5	487	c.370C>T	c.(370-372)Ctt>Ttt	p.L124F	CBX8_ENST00000485449.1_5'UTR	NM_020649.2	NP_065700.1	Q9HC52	CBX8_HUMAN	chromobox homolog 8	124					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)	14			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			ATGTTTCGAAGGCCCTCCCGG	0.682000													8	10					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98146820	98146820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98146820G>A	ENST00000357947.3	-	14	1967	c.1742C>T	c.(1741-1743)tCc>tTc	p.S581F		NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	581	EGF-like 1; calcium-binding (Potential).			EVDECSWPDHGGCEHRCV -> GKKKKKKKKKKKKKKKKK (in Ref. 5; AAH13871).	cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		ATCTGGCCAGGAACACTCATC	0.597000													21	54					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47379867	47379867	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47379867C>T	ENST00000285039.7	-	31	4472	c.4173G>A	c.(4171-4173)gtG>gtA	p.V1391V	MYO5B_ENST00000324581.6_Silent_p.V506V	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1391					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CGCCGAATTCCACCTGGGCCT	0.567000													35	70					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73636695	73636695	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:73636695C>T	ENST00000377687.4	+	2	1494	c.958C>T	c.(958-960)Cag>Tag	p.Q320*	KLF5_ENST00000477333.1_3'UTR|KLF5_ENST00000539231.1_Nonsense_Mutation_p.Q229*	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	320					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		AGAGATGCTCCAGAATTTAAC	0.473000													36	140					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48813009	48813009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48813009G>A	ENST00000316623.5	-	10	1449	c.994C>T	c.(994-996)Cgc>Tgc	p.R332C		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	332					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TATCCTGGGCGAACATCTGAG	0.517000													22	53					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27948152	27948152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27948152C>T	ENST00000374005.3	-	5	634	c.346G>A	c.(346-348)Gag>Aag	p.E116K	FGR_ENST00000399173.1_Missense_Mutation_p.E116K|FGR_ENST00000374004.1_Missense_Mutation_p.E116K|FGR_ENST00000545953.1_Intron	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	116	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GACCGAGCCTCCCACCAGTCA	0.592000													27	70					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50546780	50546780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50546780C>T	ENST00000267845.3	-	5	925	c.523G>A	c.(523-525)Gat>Aat	p.D175N	HDC_ENST00000543581.1_Missense_Mutation_p.D175N	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	175					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TCATCAGCATCGGGCTCAGAC	0.547000													26	50					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210857051	210857051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210857051C>T	ENST00000367007.4	-	11	2630	c.2461G>A	c.(2461-2463)Gag>Aag	p.E821K	KCNH1_ENST00000271751.4_Missense_Mutation_p.E848K	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	848					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TTCCAGTCCTCACTCTTCCCG	0.612000													38	97					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17787380	17787380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:17787380C>T	ENST00000380607.4	+	5	454	c.334C>T	c.(334-336)Cca>Tca	p.P112S	SH3GL2_ENST00000537391.1_Missense_Mutation_p.P65S	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	112	BAR.|Binds and tubulates liposomes (By similarity).				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		TCTCCTAGGCCCAGCACTTGG	0.468000													13	131					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160915041	160915041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160915041G>A	ENST00000368029.3	-	8	924	c.867C>T	c.(865-867)ccC>ccT	p.P289P	RP11-544M22.1_ENST00000356006.3_RNA|ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	289					signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CACACTGACGGGGTTTGCCCT	0.532000													22	37					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354341	45354341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45354341C>T	ENST00000359271.2	+	2	916	c.666C>T	c.(664-666)ttC>ttT	p.F222F		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	222						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				TGGACCTCTTCAGGGCACGCG	0.627000													31	86					0	0	1	0	0
TULP3	7289	broad.mit.edu	37	12	3040254	3040254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:3040254C>T	ENST00000448120.2	+	6	595	c.544C>T	c.(544-546)Ctg>Ttg	p.L182L	TULP3_ENST00000397132.2_Silent_p.L182L	NM_003324.4	NP_003315.2	O75386	TULP3_HUMAN	tubby like protein 3	182					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding			endometrium(1)|large_intestine(4)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			TGATAACCTCCTGGGAGACAT	0.512000													38	86					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457945	45457945	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45457945G>A	ENST00000548424.1	+	0	448																											TCACTCTGAGGAATTTCTCTT	0.428000													8	93					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427641	119427641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119427641G>A	ENST00000369429.3	-	8	1532	c.1523C>T	c.(1522-1524)gCc>gTc	p.A508V	TBX15_ENST00000207157.3_Missense_Mutation_p.A402V			Q96SF7	TBX15_HUMAN	T-box 15	508						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AAGGGAGAAGGCATTGTAGGA	0.537000													13	38					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175471	57175471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57175471C>T	ENST00000537055.2	-	2	1327	c.1096G>A	c.(1096-1098)Gac>Aac	p.D366N		NM_001005850.2	NP_001005850.2			zinc finger protein 835									p.D388N(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						TTGCCGCAGTCGTGGCAGGGG	0.701000													12	14					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79363156	79363156	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79363156G>A	ENST00000444841.1	-	0	1182																											AATGTCCCAGGATTTGTAGGA	0.517000													6	24					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2217047	2217047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2217047C>T	ENST00000398665.3	+	21	2538	c.2502C>T	c.(2500-2502)tcC>tcT	p.S834S		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	834						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCCCTGTCCCCTGGGGCCT	0.677000													16	42					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30926323	30926323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30926323G>A	ENST00000383096.3	-	9	692	c.510C>T	c.(508-510)gcC>gcT	p.A170A	CCDC178_ENST00000402325.1_Silent_p.A170A|CCDC178_ENST00000583930.1_Silent_p.A170A|CCDC178_ENST00000406524.2_Silent_p.A170A|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000579947.1_Silent_p.A170A|CCDC178_ENST00000403303.1_Silent_p.A170A|CCDC178_ENST00000300227.8_Silent_p.A170A					coiled-coil domain containing 178																		TGAGACGAATGGCCTCTGAGA	0.338000													34	91					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104948883	104948883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:104948883G>A	ENST00000507740.1	+	10	2092	c.1856G>A	c.(1855-1857)cGa>cAa	p.R619Q	RIMS2_ENST00000406091.3_Missense_Mutation_p.R827Q|RIMS2_ENST00000262231.10_Missense_Mutation_p.R666Q|RIMS2_ENST00000436393.2_Missense_Mutation_p.R605Q	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	889					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TTTCGGGAACGAATGCTAGAG	0.383000										HNSCC(12;0.0054)			14	168					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6649939	6649939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6649939C>T	ENST00000299441.3	-	13	5695	c.5284G>A	c.(5284-5286)Gag>Aag	p.E1762K		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1762	Cadherin 17.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCTGGCCCTCAGGCACCTCC	0.572000													7	93					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	182994669	182994669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:182994669G>A	ENST00000328913.3	-	15	2150	c.1853C>T	c.(1852-1854)tCc>tTc	p.S618F	MCF2L2_ENST00000447025.2_Missense_Mutation_p.S618F|MCF2L2_ENST00000473233.1_Missense_Mutation_p.S618F|MCF2L2_ENST00000414362.2_Missense_Mutation_p.S618F	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	618					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.S618F(1)		breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CCTGCGGGGGGAAAGGTCTCC	0.557000													8	15					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58302915	58302915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:58302915C>T	ENST00000249750.4	-	4	1192	c.425G>A	c.(424-426)gGc>gAc	p.G142D	ALDH1A2_ENST00000347587.3_Missense_Mutation_p.G142D|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.G46D|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.G113D|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.G121D	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	142					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTTGATGACGCCCTGCAAATC	0.428000													22	51					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200877935	200877935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200877935G>A	ENST00000367342.4	+	7	1107	c.907G>A	c.(907-909)Ggt>Agt	p.G303S	C1orf106_ENST00000413687.2_Missense_Mutation_p.G218S	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	303	Pro-rich.									endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						AACCCTTGAGGGTCTGCAGCC	0.602000													51	104					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14812906	14812906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14812906C>T	ENST00000380881.4	-	17	3615	c.2800G>A	c.(2800-2802)Gaa>Aaa	p.E934K	FREM1_ENST00000422223.2_Missense_Mutation_p.E933K|FREM1_ENST00000380880.3_Missense_Mutation_p.E933K			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	933					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TGCTGAGGTTCGCGAGCAATC	0.478000													72	136					0	0	1	0	0
UBE2W	55284	broad.mit.edu	37	8	74722759	74722759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:74722759G>A	ENST00000517608.1	-	4	403	c.403C>T	c.(403-405)Caa>Taa	p.Q135*	RP11-463D19.2_ENST00000358757.5_Nonsense_Mutation_p.Q106*|UBE2W_ENST00000602593.1_Nonsense_Mutation_p.Q106*|UBE2W_ENST00000453587.2_Nonsense_Mutation_p.Q106*|UBE2W_ENST00000419880.3_Nonsense_Mutation_p.Q146*|UBE2W_ENST00000602969.1_Nonsense_Mutation_p.Q117*			Q96B02	UBE2W_HUMAN	ubiquitin-conjugating enzyme E2W (putative)	106					protein K11-linked ubiquitination|protein monoubiquitination		ATP binding|protein binding|ubiquitin-protein ligase activity			kidney(1)|lung(1)	2	Breast(64;0.0311)		Epithelial(68;0.0235)|all cancers(69;0.0687)|BRCA - Breast invasive adenocarcinoma(89;0.069)			CAAACTGATTGGACTGAGAGC	0.378000													30	83					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10104446	10104446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10104446C>T	ENST00000264828.3	-	17	1709	c.1624G>A	c.(1624-1626)Ggg>Agg	p.G542R		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	542	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent	p.G542R(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CCAGTGTCCCCTGGGAGGCCC	0.582000													41	98					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196771386	196771386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196771386C>T	ENST00000312428.6	-	27	4432	c.4332G>A	c.(4330-4332)ctG>ctA	p.L1444L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1444	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCATACCTTCAGGTTATCTG	0.388000													41	96					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178409938	178409938	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178409938G>A	ENST00000231188.5	-	9	2587	c.2409C>T	c.(2407-2409)ttC>ttT	p.F803F	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Silent_p.F803F	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	803					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CAGTGCCAAAGAAGATGGGCA	0.562000													34	58					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38433628	38433628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38433628C>T	ENST00000356264.2	-	18	1800	c.1585G>A	c.(1585-1587)Gag>Aag	p.E529K	AMPH_ENST00000428293.2_Missense_Mutation_p.E487K|AMPH_ENST00000325590.5_Missense_Mutation_p.E487K|AMPH_ENST00000471913.1_5'UTR	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	529					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						GCTTCGAGCTCCTCTGCTTCA	0.572000													28	130					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	82147811	82147811	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:82147811G>A	ENST00000550584.2	-	2	485	c.190C>T	c.(190-192)Cag>Tag	p.Q64*	PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.Q64*|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.Q64*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.Q64*|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.Q64*|PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.Q64*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	323										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ATGACATCCTGAAGTCTTTGC	0.483000													4	36					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3674315	3674315	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3674315G>A	ENST00000344754.4	-	13	3286	c.3287C>T	c.(3286-3288)aCc>aTc	p.T1096I	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.T1096I	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1096	Ig-like C2-type 11.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CTCCCGCACGGTAGCCCCGGG	0.647000													10	30					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760277	20760277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20760277C>T	ENST00000400451.2	+	5	1468	c.954C>T	c.(952-954)tcC>tcT	p.S318S	ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Silent_p.S318S|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000405993.1_Silent_p.S286S	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	318					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCACTCGTCCCTCAACGTGC	0.657000													35	79					0	0	1	0	0
AOC3	8639	broad.mit.edu	37	17	41003708	41003708	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:41003708G>A	ENST00000308423.2	+	1	508	c.348G>A	c.(346-348)ggG>ggA	p.G116G		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	116					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	TGGACAGGGGGAGCCCCCCAC	0.667000													22	31					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142643344	142643344	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142643344G>A	ENST00000355265.2	-	11	1738	c.1264C>T	c.(1264-1266)Ctg>Ttg	p.L422L	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	422					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AAAGCCGCCAGCGTGGGCTCG	0.592000													4	44					0	0	1	0	0
IARS2	55699	broad.mit.edu	37	1	220307845	220307845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:220307845C>T	ENST00000366922.1	+	15	2054	c.1723C>T	c.(1723-1725)Cct>Tct	p.P575S	IARS2_ENST00000302637.5_Missense_Mutation_p.P647S			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	647					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	GAAGAGAGCACCTTATAAGTA	0.458000													20	75					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21217065	21217065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21217065G>A	ENST00000380216.1	-	1	245	c.240C>T	c.(238-240)ttC>ttT	p.F80F		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	80					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TCATCTCATGGAAGGCAGAGA	0.473000													61	119					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94376979	94376979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94376979C>T	ENST00000282020.4	+	11	1970	c.1712C>T	c.(1711-1713)gCt>gTt	p.A571V	GRID2_ENST00000510992.1_Missense_Mutation_p.A476V	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	571					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCTCTATGGGCTTGCATTGCT	0.478000													48	104					0	0	1	0	0
MAN1A1	4121	broad.mit.edu	37	6	119569512	119569512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:119569512C>T	ENST00000368468.3	-	6	1346	c.905G>A	c.(904-906)cGa>cAa	p.R302Q	MAN1A1_ENST00000368466.2_Missense_Mutation_p.R325Q	NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	302					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TGCTTTCTTTCGAAAAATCTG	0.348000													19	38					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232561373	232561373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:232561373G>A	ENST00000366630.1	-	17	4950	c.4592C>T	c.(4591-4593)cCg>cTg	p.P1531L	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.P1531L|SIPA1L2_ENST00000308942.4_Missense_Mutation_p.P605L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1531					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GTGGGCCCGCGGAGGCAGCGT	0.667000													9	15					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29562639	29562639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:29562639C>T	ENST00000358273.4	+	28	4102	c.3719C>T	c.(3718-3720)gCt>gTt	p.A1240V	NF1_ENST00000356175.3_Missense_Mutation_p.A1240V	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1240	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GATGAACTAGCTCGAGTTCTG	0.383000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			17	205					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110754783	110754783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110754783C>T	ENST00000369787.3	+	1	689	c.662C>T	c.(661-663)tCc>tTc	p.S221F	KCNC4_ENST00000438661.2_Missense_Mutation_p.S221F|KCNC4_ENST00000413138.3_Missense_Mutation_p.S221F|KCNC4_ENST00000412512.2_3'UTR	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	221					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		GATCCCTACTCCTCCCGGGCC	0.736000													5	9					0	0	1	0	0
ACTG1P17	283693	broad.mit.edu	37	15	83395485	83395485	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83395485G>A	ENST00000560958.1	-	0	801					NR_036446.1																						TCTCCAGGAAGGAAGAGGACA	0.572000													3	10					0	0	1	0	0
SLC41A2	84102	broad.mit.edu	37	12	105199034	105199034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:105199034G>A	ENST00000258538.3	-	10	1745	c.1618C>T	c.(1618-1620)Ccc>Tcc	p.P540S	SLC41A2_ENST00000549713.1_5'UTR	NM_032148.3	NP_115524.3	Q96JW4	S41A2_HUMAN	solute carrier family 41 (magnesium transporter), member 2	540						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	22						GTTAGGTAGGGGATGGAGAAA	0.463000													29	256					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729430	196729430	+	Nonsense_Mutation	SNP	G	G	A	rs115474479	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196729430G>A	ENST00000312428.6	-	41	7049	c.6949C>T	c.(6949-6951)Cga>Tga	p.R2317*		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2317	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R2317*(1)		NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATGGCAAATCGAAACAAGACA	0.443000													51	148					0	0	1	0	0
MATK	4145	broad.mit.edu	37	19	3783164	3783164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3783164C>T	ENST00000310132.6	-	7	1034	c.636G>A	c.(634-636)cgG>cgA	p.R212R	MATK_ENST00000585778.1_Silent_p.R212R|MATK_ENST00000395045.2_Silent_p.R213R|MATK_ENST00000395040.2_Silent_p.R171R	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	212					cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCCGTGTTTCCGCTTTGGTC	0.652000													19	80					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50055532	50055532	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50055532G>A	ENST00000281631.5	+	4	398	c.240G>A	c.(238-240)gaG>gaA	p.E80E	PARP8_ENST00000511363.2_Intron|PARP8_ENST00000505697.2_Silent_p.E80E|PARP8_ENST00000503750.2_Silent_p.E80E|PARP8_ENST00000505554.1_Silent_p.E59E|PARP8_ENST00000514067.2_Silent_p.E80E|PARP8_ENST00000514342.2_5'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	80						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				TTACTACAGAGCCAATACCAG	0.249000													9	102					0	0	1	0	0
KCNS1	3787	broad.mit.edu	37	20	43723679	43723679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43723679C>T	ENST00000306117.1	-	5	1809	c.1413G>A	c.(1411-1413)gaG>gaA	p.E471E	KCNS1_ENST00000537075.1_Silent_p.E471E	NM_002251.3	NP_002242.2	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	471						voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding			endometrium(1)|lung(3)|ovary(1)|stomach(1)	6		Myeloproliferative disorder(115;0.0122)				GCACGGCTGCCTCCAGAGCCT	0.577000													64	124					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107978025	107978025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107978025G>A	ENST00000372129.2	-	1	1626	c.1550C>T	c.(1549-1551)tCg>tTg	p.S517L		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	517						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GTTTCCTCCCGAGCTATGGCT	0.597000													40	61					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20329723	20329723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20329723C>T	ENST00000302555.5	-	7	1186	c.1037G>A	c.(1036-1038)gGa>gAa	p.G346E	GP2_ENST00000381360.5_Missense_Mutation_p.G202E|GP2_ENST00000381362.4_Missense_Mutation_p.G349E|GP2_ENST00000341642.5_Missense_Mutation_p.G199E|GP2_ENST00000573897.1_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	349	ZP.					anchored to membrane|extracellular region|plasma membrane		p.G346E(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AATGAACTCTCCATTCCCGTC	0.473000													14	159					0	0	1	0	0
NEK3	4752	broad.mit.edu	37	13	52718862	52718862	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52718862G>A	ENST00000452082.2	-	8	2061	c.831C>T	c.(829-831)atC>atT	p.I277I	NEK3_ENST00000339406.3_Silent_p.I256I|NEK3_ENST00000378101.2_Silent_p.I256I|NEK3_ENST00000400357.2_Silent_p.I256I			P51956	NEK3_HUMAN	NIMA-related kinase 3	256	Interaction with VAV2.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|stomach(2)	18		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		GCCGAGCTACGATGCCTCGAG	0.463000													9	32					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79121182	79121182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:79121182C>T	ENST00000370747.4	+	5	911	c.826C>T	c.(826-828)Cgt>Tgt	p.R276C	IFI44_ENST00000495254.1_3'UTR|IFI44_ENST00000545124.1_5'UTR	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	276					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						CGGTAACATTCGTGATAGATA	0.353000													11	74					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29012450	29012450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29012450C>T	ENST00000282397.4	-	4	672	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	FLT1_ENST00000539099.1_Missense_Mutation_p.E141K|FLT1_ENST00000541932.1_Missense_Mutation_p.E141K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	141					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TCGGGGATTTCACTGTACATC	0.373000													15	42					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36679919	36679919	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36679919G>A	ENST00000265113.4	+	7	1527	c.1051G>A	c.(1051-1053)Ggg>Agg	p.G351R	SLC1A3_ENST00000381918.3_Missense_Mutation_p.G351R|CTD-2353F22.1_ENST00000510740.1_RNA	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	351					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TTTTATTGGAGGGTTGCTGCA	0.483000													30	58					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424752	125424752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125424752G>A	ENST00000373686.1	+	1	908	c.908G>A	c.(907-909)gGa>gAa	p.G303E				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						CTGTTTTATGGAAGCATTAGC	0.423000													55	166					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10443963	10443963	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10443963C>T	ENST00000245503.5	-	11	1340	c.956G>A	c.(955-957)gGg>gAg	p.G319E	MYH2_ENST00000397183.2_Missense_Mutation_p.G319E|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Missense_Mutation_p.G319E	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	319	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ACTGATCTCCCCTTGACTGAC	0.383000													8	28					0	0	1	0	0
CD300LB	124599	broad.mit.edu	37	17	72522000	72522000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72522000G>A	ENST00000392621.1	-	2	372	c.368C>T	c.(367-369)aCg>aTg	p.T123M	CD300LB_ENST00000314401.3_Missense_Mutation_p.T123M	NM_174892.2	NP_777552.2	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	86						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(1)	21						CACAGTGAACGTGCGGTCTTT	0.522000													65	134					0	0	1	0	0
HRH3	11255	broad.mit.edu	37	20	60791598	60791598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60791598C>T	ENST00000340177.5	-	3	1086	c.802G>A	c.(802-804)Gag>Aag	p.E268K	HRH3_ENST00000317393.6_Missense_Mutation_p.E268K	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	268					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	GGCATGGCCTCCCCGTGCCCC	0.776000													5	7					0	0	1	0	0
RNASE3	6037	broad.mit.edu	37	14	21359902	21359902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21359902G>A	ENST00000304639.3	+	2	115	c.57G>A	c.(55-57)atG>atA	p.M19I		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	19					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	TGGGGCTTATGGGTGTGGAGG	0.512000													66	149					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45451937	45451937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45451937C>T	ENST00000331493.2	+	12	1388	c.977C>T	c.(976-978)tCt>tTt	p.S326F	EFCAB13_ENST00000517484.1_Missense_Mutation_p.S230F	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		AATAGTTTGTCTTCCAAACTC	0.303000													29	42					0	0	1	0	0
ALKBH1	8846	broad.mit.edu	37	14	78142163	78142163	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:78142163G>A	ENST00000216489.3	-	5	591	c.576C>T	c.(574-576)ttC>ttT	p.F192F		NM_006020.2	NP_006011.2	Q13686	ALKB1_HUMAN	alkB, alkylation repair homolog 1 (E. coli)	192					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		GGTCAGAAGGGAAAGGTGTGT	0.418000													18	60					0	0	1	0	0
IP6K2	51447	broad.mit.edu	37	3	48727117	48727117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48727117G>A	ENST00000328631.5	-	5	857	c.634C>T	c.(634-636)Cgc>Tgc	p.R212C		NM_001005909.2|NM_016291.3	NP_001005909.1|NP_057375.2	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	212					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						ACCTCGTAGCGGGAAGTCAGG	0.478000													23	45					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101845424	101845424	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101845424C>T	ENST00000360264.3	+	18	2900	c.2880C>T	c.(2878-2880)acC>acT	p.T960T	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000556210.1_Silent_p.T791T|CUX1_ENST00000550008.2_Silent_p.T893T|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000292535.7_Silent_p.T949T|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000546411.2_Silent_p.T847T|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000549414.2_Silent_p.T927T	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	949					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCGAGCTCACCCGGCAGGTTA	0.597000													12	139					0	0	1	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067202	18067202	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18067202C>T	ENST00000506618.2	-	1	284	c.204G>A	c.(202-204)atG>atA	p.M68I		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	68					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TCAAAAGCTCCATTAGACTGT	0.478000													102	278					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235148	5235148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:5235148C>T	ENST00000274181.7	+	13	2010	c.1872C>T	c.(1870-1872)ttC>ttT	p.F624F		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	624	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						GAGGGAAGTTCTGTGAGGGCT	0.448000													25	62					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121293253	121293253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121293253C>T	ENST00000297848.3	+	31	4049	c.3779C>T	c.(3778-3780)cCa>cTa	p.P1260L	COL14A1_ENST00000247781.3_Missense_Mutation_p.P1165L|COL14A1_ENST00000309791.4_Missense_Mutation_p.P1260L	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1260	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AATGTGTTTCCATGTTACCAA	0.368000													23	111					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129070689	129070689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:129070689G>A	ENST00000274487.4	+	22	3504	c.3359G>A	c.(3358-3360)gGa>gAa	p.G1120E	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1120	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AAGATCACAGGAAGACATGGA	0.388000													25	77					0	0	1	0	0
CMTM5	116173	broad.mit.edu	37	14	23846556	23846556	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23846556C>T	ENST00000359320.3	+	1	540	c.96C>T	c.(94-96)tcC>tcT	p.S32S	CMTM5_ENST00000382809.2_Silent_p.S32S|CMTM5_ENST00000397227.3_Silent_p.S32S|CMTM5_ENST00000555731.1_Silent_p.S32S|CMTM5_ENST00000339180.4_Silent_p.S32S|CMTM5_ENST00000342473.4_Silent_p.S32S	NM_138460.2	NP_612469.1	Q96DZ9	CKLF5_HUMAN	CKLF-like MARVEL transmembrane domain containing 5	32	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	8	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		TCCTCACCTCCCACAAGGGCA	0.647000													17	67					0	0	1	0	0
AQP9	366	broad.mit.edu	37	15	58430764	58430764	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:58430764G>A	ENST00000219919.4	+	0	370				AQP9_ENST00000536493.1_De_novo_Start_InFrame|ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000559443.1_3'UTR|AQP9_ENST00000558772.1_Intron	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9						cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		GAAGCCCCAAGATGCAGCCTG	0.488000													12	35					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1270929	1270929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1270929G>A	ENST00000447027.1	+	31	12886	c.12828G>A	c.(12826-12828)ccG>ccA	p.P4276P	MUC5B_ENST00000529681.1_Silent_p.P4273P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4273	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCTCCACCCCGGGAACAGCTC	0.637000													24	154					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	13935508	13935508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:13935508C>T	ENST00000343495.5	-	13	2101	c.1363G>A	c.(1363-1365)Gaa>Aaa	p.E455K	ETV1_ENST00000430479.1_Missense_Mutation_p.E473K|ETV1_ENST00000405358.4_Missense_Mutation_p.E487K|ETV1_ENST00000420159.2_Missense_Mutation_p.E415K|ETV1_ENST00000403527.1_Missense_Mutation_p.E433K|ETV1_ENST00000399357.3_Missense_Mutation_p.E370K|ETV1_ENST00000403685.1_Missense_Mutation_p.E455K|ETV1_ENST00000405218.2_Missense_Mutation_p.E473K|ETV1_ENST00000405192.2_Missense_Mutation_p.E450K|ETV1_ENST00000242066.5_Missense_Mutation_p.E455K			P50549	ETV1_HUMAN	ets variant 1	473					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E473K(1)	TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						ACGTAGCCTTCGTTGTAGGGG	0.478000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								8	19					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14489121	14489121	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14489121C>T	ENST00000454876.2	+	5	725	c.396C>T	c.(394-396)tcC>tcT	p.S132S	SLC6A6_ENST00000360861.3_Silent_p.S132S|SLC6A6_ENST00000484191.1_3'UTR|SLC6A6_ENST00000416216.2_Silent_p.S132S			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	132					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						TAATTGTGTCCCTCCTGAATG	0.542000													47	577					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84270636	84270636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:84270636G>A	ENST00000428679.2	-	27	3066	c.2473C>T	c.(2473-2475)Cct>Tct	p.P825S	SNAP91_ENST00000520302.1_Missense_Mutation_p.P795S|SNAP91_ENST00000369694.2_Missense_Mutation_p.P825S|SNAP91_ENST00000439399.2_Missense_Mutation_p.P825S|SNAP91_ENST00000520213.1_Missense_Mutation_p.P518S|SNAP91_ENST00000195649.6_Missense_Mutation_p.P820S|SNAP91_ENST00000521743.1_Missense_Mutation_p.P825S|SNAP91_ENST00000437520.1_Missense_Mutation_p.P518S|SNAP91_ENST00000521485.1_Missense_Mutation_p.P820S			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	825	Pro-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GCAACAGGAGGAACTGAACTG	0.423000													14	11					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171264339	171264339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171264339C>T	ENST00000334231.6	+	22	2662	c.2662C>T	c.(2662-2664)Cct>Tct	p.P888S	MYO3B_ENST00000408978.4_Missense_Mutation_p.P879S|MYO3B_ENST00000409044.3_Missense_Mutation_p.P879S|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	879	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						CTTCTCAATCCCTCTGACCAA	0.463000													57	148					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52852284	52852284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52852284G>A	ENST00000266041.4	-	19	2264	c.2168C>T	c.(2167-2169)aCc>aTc	p.T723I	ITIH4_ENST00000485816.1_Missense_Mutation_p.T728I|ITIH4_ENST00000406595.1_Missense_Mutation_p.T693I|ITIH4_ENST00000346281.5_Missense_Mutation_p.T693I	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	723					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TGGGGTTTGGGTTGTCATGGT	0.597000													11	65					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807339	143807339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143807339G>A	ENST00000408979.2	+	1	733	c.664G>A	c.(664-666)Ggg>Agg	p.G222R		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					GCACATCCTCGGGGCCATCCT	0.517000													61	136					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74595936	74595936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74595936G>A	ENST00000361874.3	-	16	2090	c.1773C>T	c.(1771-1773)ttC>ttT	p.F591F	DCTN1_ENST00000394003.3_Silent_p.F584F|DCTN1_ENST00000409567.3_Silent_p.F571F|DCTN1_ENST00000407639.2_Silent_p.F457F|DCTN1_ENST00000409438.1_Silent_p.F457F|DCTN1_ENST00000409868.1_Silent_p.F574F|DCTN1_ENST00000409240.1_Silent_p.F554F	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	591					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						TGTCAGGCATGAAGGCTGTCA	0.547000													26	78					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249993	52249993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52249993C>T	ENST00000595042.1	-	3	396	c.255G>A	c.(253-255)aaG>aaA	p.K85K	FPR1_ENST00000304748.4_Silent_p.K85K	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	85					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CTCCCATGGCCTTCCTGACCA	0.512000													11	104					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396858	154396858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154396858C>T	ENST00000435029.4	+	1	3599	c.3439C>T	c.(3439-3441)Cct>Tct	p.P1147S		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1147	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACTGGAGGATCCTACCGAGGT	0.542000													38	62					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179499268	179499268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179499268C>T	ENST00000589042.1	-	230	42464	c.42240G>A	c.(42238-42240)gaG>gaA	p.E14080E	TTN_ENST00000342992.6_Silent_p.E11512E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Silent_p.E5015E|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.E5207E|TTN_ENST00000359218.5_Silent_p.E5140E|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.E12439E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12439	Fibronectin type-III 1.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACATTTGCCTCTCGGGTGA	0.398000													50	131					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25708275	25708275	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:25708275T>A	ENST00000520164.1	-	15	2068	c.1531A>T	c.(1531-1533)Atg>Ttg	p.M511L	EBF2_ENST00000535548.1_3'UTR|EBF2_ENST00000408929.3_Missense_Mutation_p.M363L	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	511	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		CTTGATGACATGACTGGAAAG	0.423000													20	45					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926127	70926127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70926127G>A	ENST00000603540.1	+	2	2169	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Silent_p.E637E	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	637	EGF-like.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCCTTCCTGAGACCTGCAATA	0.507000													26	65					0	0	1	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20077862	20077862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:20077862C>T	ENST00000276390.2	+	14	1525	c.1485C>T	c.(1483-1485)atC>atT	p.I495I		NM_001693.3	NP_001684.2	P21281	VATB2_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	495					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(1)|kidney(2)|lung(5)|prostate(1)	9				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TGAAGAGAATCCCTCAGAGCA	0.463000													26	103					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25228586	25228586	+	Missense_Mutation	SNP	G	G	A	rs61733055	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:25228586G>A	ENST00000219660.5	+	2	205	c.80G>A	c.(79-81)cGa>cAa	p.R27Q	AQP8_ENST00000566125.1_Missense_Mutation_p.R21Q	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	27					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		GGCAGGTGGCGAGTGTCCTGG	0.577000													63	245					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171406482	171406482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:171406482G>A	ENST00000356327.5	-	14	1593	c.1523C>T	c.(1522-1524)tCt>tTt	p.S508F	PLD1_ENST00000351298.4_Missense_Mutation_p.S508F|PLD1_ENST00000342215.6_Missense_Mutation_p.S508F|PLD1_ENST00000340989.4_Missense_Mutation_p.S508F	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	508	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GGAACCCAGAGACGGTCCTGA	0.453000													9	82					0	0	1	0	0
WASF1	8936	broad.mit.edu	37	6	110423024	110423024	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110423024G>A	ENST00000392589.1	-	10	2125	c.1289C>T	c.(1288-1290)cCt>cTt	p.P430L	WASF1_ENST00000359451.2_Missense_Mutation_p.P430L|WASF1_ENST00000392588.1_Missense_Mutation_p.P430L|WASF1_ENST00000392586.1_Missense_Mutation_p.P430L|WASF1_ENST00000392587.2_Missense_Mutation_p.P430L	NM_003931.2	NP_003922.1	Q92558	WASF1_HUMAN	WAS protein family, member 1	430	Poly-Pro.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		AGGCAGAGGAGGCGGTGGTGG	0.572000													30	41					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49598400	49598400	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49598400C>T	ENST00000527477.1	+	0	1004																											AGGCAAGGTCCATGGTGGACA	0.443000													35	26					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119434453	119434453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119434453C>T	ENST00000273390.5	+	6	622	c.545C>T	c.(544-546)tCc>tTc	p.S182F	MAATS1_ENST00000463700.1_Missense_Mutation_p.S182F	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		AAGCACCTATCCATCCCTTCA	0.388000													83	227					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160114891	160114891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:160114891C>T	ENST00000327245.5	-	5	1037	c.191G>A	c.(190-192)aGg>aAg	p.R64K	ATP10B_ENST00000518411.1_5'UTR|CTC-529G1.1_ENST00000524198.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	64					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGGTATCTCCTGGAGACCTC	0.498000													14	210					0	0	1	0	0
PLEK2	26499	broad.mit.edu	37	14	67864445	67864445	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:67864445G>A	ENST00000216446.4	-	2	281	c.141C>T	c.(139-141)ccC>ccT	p.P47P		NM_016445.1	NP_057529.1	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	47	PH 1.				actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	15				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		TCCGGCCCTTGGGAGGGGTCA	0.602000													8	25					0	0	1	0	0
RHOXF2	84528	broad.mit.edu	37	X	119293315	119293315	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:119293315C>T	ENST00000371388.3	+	2	664	c.474C>T	c.(472-474)ttC>ttT	p.F158F		NM_032498.1	NP_115887.1	Q9BQY4	RHXF2_HUMAN	Rhox homeobox family, member 2	158						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|skin(2)	8						GCGAGCAGTTCCCCAGTGAGT	0.652000													9	5					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17743712	17743712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17743712C>T	ENST00000428389.2	-	29	3570	c.3571G>A	c.(3571-3573)Gac>Aac	p.D1191N	UNC13A_ENST00000552293.1_Missense_Mutation_p.D1103N|UNC13A_ENST00000519716.2_Missense_Mutation_p.D1103N|UNC13A_ENST00000551649.1_Missense_Mutation_p.D1103N|UNC13A_ENST00000550896.1_Missense_Mutation_p.D1101N|UNC13A_ENST00000252773.7_Missense_Mutation_p.D1103N			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1103	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CGATGCTTGTCGTGCTCTGGC	0.537000													17	38					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40743889	40743889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40743889C>T	ENST00000373198.3	-	23	3350	c.3115G>A	c.(3115-3117)Gaa>Aaa	p.E1039K	PTPRT_ENST00000373193.3_Missense_Mutation_p.E1020K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E1027K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E1007K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E1016K|PTPRT_ENST00000373187.1_Missense_Mutation_p.E1017K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E1026K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1017	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCTCTGTTTCAATCAGGGTG	0.532000													33	84					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95347003	95347003	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95347003C>T	ENST00000371483.4	+	4	827	c.771C>T	c.(769-771)ctC>ctT	p.L257L	FFAR4_ENST00000604414.1_Intron|FFAR4_ENST00000371481.4_Silent_p.L241L	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		GGAAGAGGCTCACGGTAAGCC	0.567000													26	53					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150881794	150881794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:150881794C>T	ENST00000474524.1	+	8	1260	c.1222C>T	c.(1222-1224)Ccc>Tcc	p.P408S	MED12L_ENST00000422248.2_Missense_Mutation_p.P408S|MED12L_ENST00000309237.4_Missense_Mutation_p.P408S|MED12L_ENST00000273432.4_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	408					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTCCAGCCTCCCCATGCCGGG	0.522000													23	84					0	0	1	0	0
MAGEA5	4104	broad.mit.edu	37	X	151283670	151283670	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151283670C>T	ENST00000509345.2	-	0	666																											TGAATCAAGTCAGCCACCTTC	0.502000													10	66					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30433256	30433256	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30433256G>A	ENST00000375978.3	-	1	164	c.90C>T	c.(88-90)gcC>gcT	p.A30A		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	30					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						AGCTCTGGATGGCCATAGCAA	0.662000													24	91					0	0	1	0	0
PROSER2	254427	broad.mit.edu	37	10	11911750	11911750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11911750G>A	ENST00000277570.5	+	4	807	c.653G>A	c.(652-654)aGg>aAg	p.R218K	PROSER2-AS1_ENST00000445498.1_RNA|PROSER2_ENST00000379200.1_Missense_Mutation_p.R22K|PROSER2-AS1_ENST00000453242.1_RNA	NM_153256.3	NP_694988.3			proline and serine-rich protein 2																		TCCCCGTTCAGGGAGGGCCGG	0.731000													3	6					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	517373	517373	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:517373C>T	ENST00000453061.2	+	9	1846	c.1740C>T	c.(1738-1740)ttC>ttT	p.F580F	PIGG_ENST00000383028.4_Silent_p.F447F|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000310340.5_Silent_p.F572F|PIGG_ENST00000504346.1_Silent_p.F491F	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	580					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CCTGGTACTTCCTTGTGAACA	0.567000													54	119					0	0	1	0	0
DIRC1	116093	broad.mit.edu	37	2	189599363	189599363	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189599363C>T	ENST00000308100.4	-	2	555	c.285G>A	c.(283-285)tgG>tgA	p.W95*	AC079613.1_ENST00000431708.1_RNA	NM_052952.2	NP_443184.1	Q969H9	DIRC1_HUMAN	disrupted in renal carcinoma 1	95										large_intestine(1)|lung(6)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00842)|Epithelial(96;0.102)			TTAATATTTTCCACCCCCTCA	0.373000													57	153					0	0	1	0	0
TTC39A	22996	broad.mit.edu	37	1	51770760	51770760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:51770760C>T	ENST00000262676.5	-	8	903	c.743G>A	c.(742-744)gGa>gAa	p.G248E	TTC39A_ENST00000262675.7_Missense_Mutation_p.G189E|TTC39A_ENST00000447632.2_Missense_Mutation_p.G252E|TTC39A_ENST00000451380.1_Missense_Mutation_p.G216E|TTC39A_ENST00000371747.3_Missense_Mutation_p.G251E|TTC39A_ENST00000371750.5_Missense_Mutation_p.G217E|TTC39A_ENST00000413473.2_Missense_Mutation_p.G220E			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	252							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						TACCTTGTTTCCTGAAAACCC	0.582000													20	48					0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048319	6048319	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6048319G>A	ENST00000316650.5	-	1	652	c.616C>T	c.(616-618)Caa>Taa	p.Q206*		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCACAAATTGGTAGATTCTG	0.453000													31	99					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519127	113519127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113519127C>T	ENST00000284601.3	-	4	2088	c.2020G>A	c.(2020-2022)Gag>Aag	p.E674K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	674					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTGATATGCTCTGTTATGTTT	0.373000													58	272					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113703917	113703917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113703917C>T	ENST00000374431.3	-	4	960	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K	LPAR1_ENST00000541779.1_Missense_Mutation_p.E194K|LPAR1_ENST00000358883.4_Missense_Mutation_p.E193K|LPAR1_ENST00000538760.1_Missense_Mutation_p.E194K|LPAR1_ENST00000374430.2_Missense_Mutation_p.E193K	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	193					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						GAACAATTTTCAATATCACAG	0.483000													41	71					0	0	1	0	0
CXorf65	158830	broad.mit.edu	37	X	70325897	70325897	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70325897G>T	ENST00000374251.4	-	3	250	c.203C>A	c.(202-204)aCa>aAa	p.T68K	CXorf65_ENST00000485951.1_5'UTR			A6NEN9	CX065_HUMAN	chromosome X open reading frame 65	68										breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)	10						GCTTCGAGCTGTAAGGTATTT	0.473000													32	14					9.65021e-13	9.69744e-13	1	1	0
TDRD5	163589	broad.mit.edu	37	1	179603649	179603649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179603649C>T	ENST00000444136.1	+	8	1434	c.1184C>T	c.(1183-1185)tCa>tTa	p.S395L	TDRD5_ENST00000367614.1_Missense_Mutation_p.S395L|TDRD5_ENST00000294848.8_Missense_Mutation_p.S395L	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	395					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CCTAGAAATTCATTGTCTACT	0.388000													46	116					0	0	1	0	0
HTRA3	94031	broad.mit.edu	37	4	8307825	8307825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8307825G>A	ENST00000307358.2	+	9	1528	c.1324G>A	c.(1324-1326)Gac>Aac	p.D442N		NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	442	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						GGGGAACGACGACCTCCTCTT	0.657000													9	43					0	0	1	0	0
CDX1	1044	broad.mit.edu	37	5	149563070	149563070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149563070G>A	ENST00000231656.8	+	3	707	c.625G>A	c.(625-627)Gag>Aag	p.E209K		NM_001804.2	NP_001795.2	P47902	CDX1_HUMAN	caudal type homeobox 1	209						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|lung(1)|ovary(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCGGGCAAAGGAGCGCAAAGT	0.612000													15	34					0	0	1	0	0
PRG3	10394	broad.mit.edu	37	11	57146261	57146261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57146261C>T	ENST00000287143.2	-	4	509	c.400G>A	c.(400-402)Ggc>Agc	p.G134S		NM_006093.3	NP_006084.2	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3	134	C-type lectin.				basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding			large_intestine(3)|lung(5)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	13						ACAAGGTTGCCTCCGTAGCAT	0.488000													20	230					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43921516	43921516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43921516G>A	ENST00000336086.6	-	2	2260	c.24C>T	c.(22-24)ttC>ttT	p.F8F	URGCP_ENST00000446958.1_Silent_p.F42F|URGCP_ENST00000223341.7_Silent_p.F8F|URGCP_ENST00000443736.1_Silent_p.F8F|RP5-1165K10.1_ENST00000603700.1_Silent_p.F42F|URGCP_ENST00000453200.1_Silent_p.F51F|URGCP_ENST00000447717.3_Silent_p.F8F|URGCP_ENST00000402306.3_Silent_p.F42F|URGCP_ENST00000497914.1_5'UTR			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	51					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ctccataacggaactcgcaat	0.398000													83	183					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43679421	43679421	+	Missense_Mutation	SNP	G	G	A	rs150587441	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43679421G>A	ENST00000404580.1	-	4	998	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C	PSG5_ENST00000366175.3_Missense_Mutation_p.R304C|PSG5_ENST00000407356.1_Missense_Mutation_p.R304C|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000342951.6_Missense_Mutation_p.R304C|PSG5_ENST00000599812.1_Missense_Mutation_p.R397C			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	304	Ig-like C2-type 2.				female pregnancy	extracellular region		p.R304C(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GCTGAGTTACGAACAGAGCAA	0.443000													106	262					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167129313	167129313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167129313G>A	ENST00000375387.4	-	17	3290	c.2950C>T	c.(2950-2952)Cct>Tct	p.P984S	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.P972S|SCN9A_ENST00000409435.1_Missense_Mutation_p.P983S|SCN9A_ENST00000303354.6_Missense_Mutation_p.P984S			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	983						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTTGCATCAGGGTCTTCTTCA	0.373000													13	30					0	0	1	0	0
ESM1	11082	broad.mit.edu	37	5	54281334	54281334	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54281334G>A	ENST00000381405.4	-	1	157	c.12C>T	c.(10-12)gtC>gtT	p.V4V	ESM1_ENST00000381403.4_Silent_p.V4V|ESM1_ENST00000598310.1_Intron	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	4					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			TCAGCAGCAAGACGCTCTTCA	0.597000													10	59					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144359624	144359624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:144359624C>T	ENST00000262995.4	+	4	1493	c.1066C>T	c.(1066-1068)Cct>Tct	p.P356S	GAB1_ENST00000505913.1_Missense_Mutation_p.P253S|GAB1_ENST00000262994.4_Missense_Mutation_p.P356S	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	356					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					TGACCGATCTCCTGTGGAAAC	0.498000													27	88					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45322051	45322051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45322051C>T	ENST00000391955.1	+	10	1292	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F	BCAM_ENST00000270233.6_Silent_p.F416F			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	416	Ig-like C2-type 2.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CTATCACCTTCGATTCCAATG	0.627000													54	96					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57379309	57379309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57379309G>A	ENST00000403558.1	+	6	1644	c.1278G>A	c.(1276-1278)atG>atA	p.M426I	SERPING1_ENST00000278407.4_Missense_Mutation_p.M383I|SERPING1_ENST00000378323.4_Missense_Mutation_p.M388I|SERPING1_ENST00000340687.6_Missense_Mutation_p.M346I|SERPING1_ENST00000378324.2_Missense_Mutation_p.M331I	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	383					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						AGGCCATCATGGAGAAACTGG	0.498000													40	119					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70319451	70319451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70319451C>T	ENST00000338508.4	-	33	5075	c.5076G>A	c.(5074-5076)caG>caA	p.Q1692Q	SHANK2_ENST00000449833.2_Silent_p.Q1096Q|SHANK2_ENST00000423696.2_Silent_p.Q1312Q|SHANK2_ENST00000409161.1_Silent_p.Q1095Q			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1312					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGGGCCGGCTCTGCAGGGTGA	0.617000													7	35					0	0	1	0	0
FAM86FP	653113	broad.mit.edu	37	12	8386984	8386984	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8386984G>A	ENST00000427893.2	-	0	782																											GCAGGACCCCGACCAGCGACA	0.587000													12	65					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48802271	48802271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48802271G>A	ENST00000316623.5	-	14	2139	c.1684C>T	c.(1684-1686)Cat>Tat	p.H562Y		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	562	EGF-like 8; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CGTGTAACATGAAAGCCCGCA	0.408000													25	66					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167517611	167517611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167517611G>A	ENST00000519204.1	+	7	1303	c.1185G>A	c.(1183-1185)gaG>gaA	p.E395E	TENM2_ENST00000403607.2_Silent_p.E349E|TENM2_ENST00000545108.1_Silent_p.E516E|TENM2_ENST00000518659.1_Silent_p.E516E|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000520394.1_Silent_p.E284E					teneurin transmembrane protein 2																		ACGGGAAGGAGAAGTGGAGTG	0.537000													23	86					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671462	39671462	+	Silent	SNP	G	G	A	rs145343844		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39671462G>A	ENST00000398930.1	+	4	633	c.279G>A	c.(277-279)ggG>ggA	p.G93G	KCNJ15_ENST00000328656.3_Silent_p.G93G|KCNJ15_ENST00000398934.1_Silent_p.G93G|KCNJ15_ENST00000398932.1_Silent_p.G93G|KCNJ15_ENST00000398938.2_Silent_p.G93G			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	93					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						TTATTCATGGGGACTTAGAAC	0.478000													49	106					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138414689	138414689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:138414689G>A	ENST00000409968.1	+	24	4512	c.4334G>A	c.(4333-4335)cGa>cAa	p.R1445Q	THSD7B_ENST00000272643.3_Missense_Mutation_p.R1448Q|THSD7B_ENST00000543459.1_Missense_Mutation_p.E280K|THSD7B_ENST00000413152.2_Missense_Mutation_p.R1417Q					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATAACGAACGAACTGTATGG	0.413000													16	48					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23083503	23083503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23083503G>A	ENST00000219689.7	-	15	2350	c.2351C>T	c.(2350-2352)tCc>tTc	p.S784F	USP31_ENST00000567975.1_Missense_Mutation_p.S77F	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	784	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		TTCACACAGGGAAGAACTTGT	0.622000													17	52					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2150448	2150448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2150448G>A	ENST00000262304.4	-	27	9725	c.9517C>T	c.(9517-9519)Ccg>Tcg	p.P3173S	PKD1_ENST00000423118.1_Missense_Mutation_p.P3173S	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	3173	PLAT.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AGGCTGTGCGGGGTGGCGATC	0.652000													7	72					0	0	1	0	0
GCM2	9247	broad.mit.edu	37	6	10876690	10876690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:10876690C>T	ENST00000379491.4	-	3	591	c.444G>A	c.(442-444)gcG>gcA	p.A148A	RP11-637O19.3_ENST00000480294.1_Intron|SYCP2L_ENST00000543878.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	148					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				GAAAAAAGATCGCGTTGCCAT	0.498000													14	47					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18896895	18896895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18896895C>T	ENST00000542601.2	-	12	1659	c.1270G>A	c.(1270-1272)Gag>Aag	p.E424K	COMP_ENST00000222271.2_Missense_Mutation_p.E457K|COMP_ENST00000425807.1_Missense_Mutation_p.E404K			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	457					anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding	p.E457K(1)		breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						TCTGAGTCCTCCTGGGCACTG	0.602000													17	29					0	0	1	0	0
MDH2	4191	broad.mit.edu	37	7	75689783	75689783	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:75689783C>T	ENST00000315758.5	+	5	616	c.522C>T	c.(520-522)atC>atT	p.I174I	MDH2_ENST00000443006.1_Silent_p.I67I|MDH2_ENST00000432020.2_Intron	NM_005918.2	NP_005909.2	P40926	MDHM_HUMAN	malate dehydrogenase 2, NAD (mitochondrial)	174					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(2)	14					NADH(DB00157)	CCCTGGACATCGTCAGAGCCA	0.522000													23	41					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2924928	2924928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:2924928G>A	ENST00000397461.1	+	8	1136	c.752G>A	c.(751-753)gGa>gAa	p.G251E	CNTN4_ENST00000418658.1_Missense_Mutation_p.G251E|CNTN4_ENST00000358480.3_Missense_Mutation_p.G32E|CNTN4_ENST00000427331.1_Missense_Mutation_p.G251E	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	251	Ig-like C2-type 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TTTGCTTTAGGAAAGTAAGTT	0.468000													6	33					0	0	1	0	0
PAPSS1	9061	broad.mit.edu	37	4	108608330	108608330	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:108608330G>A	ENST00000265174.4	-	4	687	c.415C>T	c.(415-417)Cgc>Tgc	p.R139C	PAPSS1_ENST00000511304.1_5'UTR	NM_005443.4	NP_005434.4	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 1	139					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|ovary(1)	16		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		GCATTGTTGCGATCCttaaaa	0.328000													26	48					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53242382	53242382	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53242382C>T	ENST00000304620.4	-	1	396	c.333G>A	c.(331-333)gaG>gaA	p.E111E		NM_173352.2	NP_775487.2	Q8N1N4	K2C78_HUMAN	keratin 78	111	Coil 1A.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						TCTCCTGGGTCTCCTGCGTCC	0.567000													9	67					0	0	1	0	0
CAMK2D	817	broad.mit.edu	37	4	114438809	114438809	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114438809G>A	ENST00000454265.2	-	9	1464	c.606C>T	c.(604-606)gtC>gtT	p.V202V	CAMK2D_ENST00000379773.2_Silent_p.V202V|CAMK2D_ENST00000296402.5_Silent_p.V202V|CAMK2D_ENST00000508738.1_Silent_p.V202V|CAMK2D_ENST00000429180.1_Silent_p.V202V|CAMK2D_ENST00000418639.2_Silent_p.V202V|CAMK2D_ENST00000515496.1_Silent_p.V202V|CAMK2D_ENST00000511664.1_Silent_p.V202V|CAMK2D_ENST00000505990.1_Silent_p.V202V|CAMK2D_ENST00000514328.1_Silent_p.V202V|CAMK2D_ENST00000394526.2_Silent_p.V202V|CAMK2D_ENST00000342666.5_Silent_p.V202V|CAMK2D_ENST00000394522.3_Silent_p.V202V|CAMK2D_ENST00000394524.3_Silent_p.V202V			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	202	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TATAGAGAATGACACCTGGAG	0.373000													13	96					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109513544	109513544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:109513544C>T	ENST00000409271.1	-	12	1705	c.1262G>A	c.(1261-1263)gGg>gAg	p.G421E	EDAR_ENST00000258443.2_Missense_Mutation_p.G389E|EDAR_ENST00000376651.1_Missense_Mutation_p.G421E			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	389	Death.				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TGTCATGCCCCCAATCTCATC	0.562000													16	38					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101776985	101776985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:101776985C>T	ENST00000251127.6	-	18	2247	c.2166G>A	c.(2164-2166)aaG>aaA	p.K722K		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	722						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGCGGTCTCCTTTTCCAGAA	0.323000													57	109					0	0	1	0	0
TMEM154	201799	broad.mit.edu	37	4	153564299	153564299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:153564299G>A	ENST00000304385.3	-	5	650	c.419C>T	c.(418-420)tCt>tTt	p.S140F		NM_152680.2	NP_689893.1	Q6P9G4	TM154_HUMAN	transmembrane protein 154	140						integral to membrane				kidney(2)|large_intestine(1)	3	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TTCCATAACAGAGGGTGTATC	0.338000													19	81					0	0	1	0	0
OBP2A	29991	broad.mit.edu	37	9	138440520	138440520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138440520C>T	ENST00000342114.4	+	4	328	c.286C>T	c.(286-288)Ccc>Tcc	p.P96S	OBP2A_ENST00000539850.1_Intron|OBP2A_ENST00000371776.1_Intron|OBP2A_ENST00000340780.3_Silent_p.S140S			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	123					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		TGCCGCTGTCCCCACCTTGGC	0.597000													4	27					0	0	1	0	0
IGHV6-1	28385	broad.mit.edu	37	14	106405642	106405642	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106405642G>A	ENST00000390593.2	-	0	383																											CGTGTCCTCGGGAGTCACAGA	0.502000													72	150					0	0	1	0	0
GJB4	127534	broad.mit.edu	37	1	35227279	35227279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35227279G>A	ENST00000339480.1	+	2	794	c.424G>A	c.(424-426)Gat>Aat	p.D142N	RP1-34M23.5_ENST00000542839.1_RNA	NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	142					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GGCCGCCGTGGATGCTGGCTT	0.612000													18	54					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323175	61323175	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61323175C>T	ENST00000283752.5	-	8	1032	c.889G>A	c.(889-891)Gac>Aac	p.D297N	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.D245N	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	297					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity	p.D297N(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						CTCAACGTGTCCTTGAGGTCA	0.488000													25	119					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209823449	209823449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209823449G>A	ENST00000391911.1	-	2	432	c.43C>T	c.(43-45)Ctg>Ttg	p.L15L	LAMB3_ENST00000356082.4_Silent_p.L15L|LAMB3_ENST00000367030.3_Silent_p.L15L	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	15					cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TGGGCATGCAGGAGGCCAGGC	0.577000													9	15					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228547865	228547865	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228547865G>A	ENST00000284548.11	+	81	19346	c.19272G>A	c.(19270-19272)atG>atA	p.M6424I	OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366709.4_Missense_Mutation_p.M3543I|OBSCN_ENST00000570156.2_Intron			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0	Ig-like 54.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGGCACCATGGAGGAGGCGG	0.637000													13	13					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050067	42050067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42050067C>T	ENST00000372584.1	-	3	1416	c.402G>A	c.(400-402)gtG>gtA	p.V134V	HIVEP3_ENST00000247584.5_Silent_p.V134V|HIVEP3_ENST00000372583.1_Silent_p.V134V|HIVEP3_ENST00000429157.2_Silent_p.V134V	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	134				FV -> LL (in Ref. 1; AAK01082).	positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCCCAGGGGCCACGAAGGAGC	0.612000													52	107					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74151734	74151734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74151734G>A	ENST00000269391.6	-	15	1739	c.1607C>T	c.(1606-1608)tCt>tTt	p.S536F	RNF157_ENST00000319945.6_Missense_Mutation_p.S536F	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	536	Ser-rich.						zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			GTAGGAGCCAGACATGGAGGA	0.617000													8	29					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47514238	47514238	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47514238G>A	ENST00000371901.3	+	10	1459	c.1207_splice	c.e10-1	p.G403_splice	CYP4X1_ENST00000538609.1_Splice_Site_p.G402_splice	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	403						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						CTTTCTTAGGGATCACCGTGG	0.428000													73	267					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152515623	152515623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152515623G>A	ENST00000427231.2	-	47	6233	c.6031C>T	c.(6031-6033)Ccc>Tcc	p.P2011S	NEB_ENST00000409198.1_Missense_Mutation_p.P2011S|NEB_ENST00000397345.3_Missense_Mutation_p.P2011S|NEB_ENST00000604864.1_Missense_Mutation_p.P2011S|NEB_ENST00000172853.10_Missense_Mutation_p.P2011S|NEB_ENST00000603639.1_Missense_Mutation_p.P2011S	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2011					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATAATCTGGGGGATATCAGGC	0.378000													73	168					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10280488	10280488	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10280488C>T	ENST00000256458.4	+	12	1620	c.1530C>T	c.(1528-1530)ctC>ctT	p.L510L		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	510					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						AGACGTTGCTCCCTTGGAGTG	0.557000													33	133					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958002	121958002	+	Missense_Mutation	SNP	G	G	A	rs143734180	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121958002G>A	ENST00000379692.4	-	4	1650	c.1124C>T	c.(1123-1125)aCc>aTc	p.T375I		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	375										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						AATAAAGAAGGTGACTTTTTG	0.418000													44	119					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167176	140167176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140167176C>T	ENST00000504120.2	+	1	1301	c.1301C>T	c.(1300-1302)tCg>tTg	p.S434L	PCDHA1_ENST00000378133.3_Missense_Mutation_p.S434L|PCDHA1_ENST00000394633.3_Missense_Mutation_p.S434L	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTCGCCTTCGCTGTGGGCC	0.627000													48	151					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111474509	111474509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111474509C>T	ENST00000265162.5	+	18	2882	c.2540C>T	c.(2539-2541)aCt>aTt	p.T847I		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	847					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CTTATTAAAACTCAGGATGTG	0.368000													29	132					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219903697	219903697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219903697G>A	ENST00000341552.5	-	3	157	c.74C>T	c.(73-75)tCt>tTt	p.S25F	CCDC108_ENST00000295729.2_Intron|CCDC108_ENST00000409865.3_Intron|CCDC108_ENST00000441968.1_Missense_Mutation_p.S25F|CCDC108_ENST00000410037.1_Intron|CCDC108_ENST00000453220.1_Missense_Mutation_p.S25F|CCDC108_ENST00000324264.6_5'UTR	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	25						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGAAAGAAGAGGCAAATGA	0.408000													35	77					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44595299	44595299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44595299C>T	ENST00000372299.3	+	2	414	c.356C>T	c.(355-357)cCc>cTc	p.P119L	KLF17_ENST00000476802.1_Intron	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	119					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					AGAATGTCTCCCCCTCAGCAA	0.552000													36	129					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149879693	149879693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149879693G>A	ENST00000369146.3	-	9	1935	c.1445C>T	c.(1444-1446)tCc>tTc	p.S482F	SV2A_ENST00000369145.1_Missense_Mutation_p.S482F	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	482					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TTTGGTGCGGGATGCGTAGTC	0.527000													47	155					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756611	15756611	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15756611C>T	ENST00000221307.7	+	3	329	c.281C>T	c.(280-282)cCc>cTc	p.P94L	CYP4F3_ENST00000591058.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000586182.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	94					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						TGGGTGGGGCCCTGGCACGCA	0.567000													27	58					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52714601	52714601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52714601C>T	ENST00000322088.6	+	4	417	c.359C>T	c.(358-360)tCg>tTg	p.S120L	PPP2R1A_ENST00000462990.1_5'UTR|PPP2R1A_ENST00000473455.2_3'UTR|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.S65L	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	120	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.S120L(1)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CACGAGCACTCGCCCTCTGAC	0.662000			Mis		clear cell ovarian carcinoma								10	89					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15303785	15303785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:15303785C>T	ENST00000383791.3	-	5	727	c.507G>A	c.(505-507)gcG>gcA	p.A169A	SH3BP5-AS1_ENST00000420195.1_RNA|SH3BP5_ENST00000253688.5_Silent_p.A12A|SH3BP5_ENST00000408919.3_Silent_p.A12A|SH3BP5_ENST00000426925.1_Silent_p.A12A	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	169					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						TGGTCTGCTCCGCCTCCATGA	0.498000													18	57					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97484999	97484999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:97484999C>T	ENST00000376705.2	+	2	987	c.963C>T	c.(961-963)ggC>ggT	p.G321G		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	321						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					GCCTGGTGGGCTGCTATAACT	0.512000													29	71					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25264767	25264767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:25264767C>T	ENST00000216962.4	+	14	1758	c.1648C>T	c.(1648-1650)Ctg>Ttg	p.L550L		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	550					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	CTCGGCCTTCCTGGAGAAGGA	0.552000													36	78					0	0	1	0	0
ZFP69B	65243	broad.mit.edu	37	1	40922631	40922631	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40922631C>T	ENST00000484445.1	+	3	508	c.142C>T	c.(142-144)Caa>Taa	p.Q48*	ZFP69B_ENST00000411995.2_Silent_p.F76F|ZFP69B_ENST00000361584.3_5'UTR					ZFP69 zinc finger protein B																		TGTTAACCTTCAAGGACGTAT	0.488000													12	23					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95676990	95676990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95676990C>T	ENST00000433389.2	+	7	900	c.710C>T	c.(709-711)tCa>tTa	p.S237L	ESRP1_ENST00000358397.5_Missense_Mutation_p.S237L|ESRP1_ENST00000454170.2_Missense_Mutation_p.S237L|ESRP1_ENST00000423620.2_Missense_Mutation_p.S237L	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	237	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding	p.S237*(2)	ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						TGGCAGTCTTCAGATCAAGAT	0.373000													19	65					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13563773	13563773	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13563773G>A	ENST00000360228.5	-	3	455	c.456C>T	c.(454-456)atC>atT	p.I152I	CACNA1A_ENST00000573710.2_Silent_p.I152I	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	152					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CAAGGGCAATGATTTTAATTC	0.498000													57	139					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91292892	91292892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91292892C>T	ENST00000355112.3	+	3	512	c.394C>T	c.(394-396)Cgg>Tgg	p.R132W	BLM_ENST00000560509.1_Missense_Mutation_p.R132W	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	132					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			AAAGAAATCCCGGGATACTGC	0.388000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				13	90					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39019006	39019006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39019006C>T	ENST00000355481.4	+	73	11001	c.10870C>T	c.(10870-10872)Cgg>Tgg	p.R3624W	RYR1_ENST00000360985.3_Missense_Mutation_p.R3629W|RYR1_ENST00000359596.3_Missense_Mutation_p.R3629W|AC067969.1_ENST00000597015.1_RNA	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3629					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.R3629W(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CAAACAGCGCCGGCGGGCAGT	0.612000													21	75					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160788098	160788098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160788098G>A	ENST00000263285.5	+	6	1463	c.1433G>A	c.(1432-1434)cGa>cAa	p.R478Q	LY9_ENST00000341032.4_Missense_Mutation_p.R388Q|LY9_ENST00000368035.1_Missense_Mutation_p.R130Q|LY9_ENST00000368040.1_Missense_Mutation_p.R130Q|LY9_ENST00000368041.2_Missense_Mutation_p.R348Q	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	478					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATTTGGAAGCGAAAAGGACGG	0.522000													9	104					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36351438	36351438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36351438C>T	ENST00000360202.5	+	7	995	c.797C>T	c.(796-798)tCt>tTt	p.S266F	KIRREL2_ENST00000347900.6_Missense_Mutation_p.S216F|KIRREL2_ENST00000592409.1_Missense_Mutation_p.S266F|KIRREL2_ENST00000586102.2_Missense_Mutation_p.S246F|KIRREL2_ENST00000262625.7_Missense_Mutation_p.S266F|NPHS1_ENST00000591817.1_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	266	Ig-like C2-type 3.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAAGGGGGCTCTCCGGTGCTC	0.642000													20	69					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52371064	52371064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52371064G>A	ENST00000296585.5	+	23	2898	c.2755G>A	c.(2755-2757)Gaa>Aaa	p.E919K		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	919					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AAGCCAAGAAGAAAACAAGGC	0.348000													21	39					0	0	1	0	0
IL2RB	3560	broad.mit.edu	37	22	37524322	37524322	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37524322C>T	ENST00000216223.5	-	10	1668	c.1470G>A	c.(1468-1470)gaG>gaA	p.E490E		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	490					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GCAGCACCAGCTCAGGGGGTG	0.667000													12	37					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5283061	5283061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5283061C>T	ENST00000546004.1	-	3	1026	c.780G>A	c.(778-780)acG>acA	p.T260T	PROKR2_ENST00000217270.3_Silent_p.T260T			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	260						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GAATCTGCTCCGTCTGGAACC	0.607000										HNSCC(71;0.22)			22	55					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63149660	63149660	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63149660G>A	ENST00000279178.3	+	6	1233	c.984G>A	c.(982-984)ctG>ctA	p.L328L	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	328					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						AAAAAGAACTGGAGGCAGCAC	0.408000													64	131					0	0	1	0	0
LRRC52	440699	broad.mit.edu	37	1	165533037	165533037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165533037C>T	ENST00000294818.1	+	2	1208	c.918C>T	c.(916-918)gtC>gtT	p.V306V	RP11-280O1.2_ENST00000421273.1_RNA|RP11-280O1.2_ENST00000438275.1_RNA|RP11-280O1.2_ENST00000416424.1_RNA	NM_001005214.3	NP_001005214.2	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52	306						integral to membrane				NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)	18	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					CGAGCTCGGTCCAGGAGTTCC	0.567000													37	93					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10071223	10071223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10071223C>T	ENST00000264828.3	-	67	5187	c.5102G>A	c.(5101-5103)gGa>gAa	p.G1701E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1701	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CTTCGTCTGTCCTTTCCGGAG	0.577000													40	103					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611474	179611474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179611474C>T	ENST00000360870.5	-	46	15875	c.15653G>A	c.(15652-15654)cGa>cAa	p.R5218Q	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8737	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R5218Q(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATTTATTTCGATACCATTT	0.373000													42	103					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90086735	90086735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90086735C>T	ENST00000405460.2	+	70	14185	c.14089C>T	c.(14089-14091)Ctt>Ttt	p.L4697F	GPR98_ENST00000425867.2_Missense_Mutation_p.L358F	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4697	Calx-beta 32.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGAAGACTTTCTTTCCACCAG	0.348000													40	85					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701558	143701558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143701558C>T	ENST00000408922.2	+	1	537	c.469C>T	c.(469-471)Ctg>Ttg	p.L157L		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TGGCATCTCCCTGGCGAAGAT	0.537000													27	45					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7950069	7950069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7950069G>A	ENST00000309838.2	-	1	140	c.141C>T	c.(139-141)gtC>gtT	p.V47V		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGGAGACGATGACTATAATAA	0.463000													41	98					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92731606	92731606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92731606C>T	ENST00000379958.2	-	3	4074	c.3805G>A	c.(3805-3807)Gat>Aat	p.D1269N		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1269						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TCAAAAAAATCAAAGGACTTT	0.313000													21	65					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43774687	43774687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43774687C>T	ENST00000372476.3	+	8	1152	c.1073C>T	c.(1072-1074)tCa>tTa	p.S358L	TIE1_ENST00000441333.2_Intron|TIE1_ENST00000433781.2_Missense_Mutation_p.S3L	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	358					mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AACATGGCCTCAGAACTGGAG	0.602000													15	70					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10576035	10576035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10576035G>A	ENST00000396560.2	+	12	2205	c.1978G>A	c.(1978-1980)Gat>Aat	p.D660N	ATF7IP2_ENST00000356427.2_Missense_Mutation_p.D660N|ATF7IP2_ENST00000396559.1_3'UTR|ATF7IP2_ENST00000543967.1_Missense_Mutation_p.D204N|ATF7IP2_ENST00000324570.5_3'UTR	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	660	Fibronectin type-III.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						CCAATCAAAAGATATTTTTGG	0.328000													16	93					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74622633	74622633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74622633G>A	ENST00000321288.5	+	14	2003	c.2003G>A	c.(2002-2004)aGc>aAc	p.S668N	CCDC33_ENST00000268082.4_Missense_Mutation_p.S58N|CCDC33_ENST00000558821.1_Missense_Mutation_p.S58N|CCDC33_ENST00000398814.3_Missense_Mutation_p.S465N			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	668							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						ATACTGAGGAGCCGCCTGGCC	0.627000													4	25					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333073	70333073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70333073C>T	ENST00000338508.4	-	32	3327	c.3328G>A	c.(3328-3330)Gat>Aat	p.D1110N	SHANK2_ENST00000449833.2_Missense_Mutation_p.D514N|SHANK2_ENST00000423696.2_Missense_Mutation_p.D730N|SHANK2_ENST00000409161.1_Missense_Mutation_p.D513N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	730					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACATCCTCATCCCCCAGGTCT	0.697000													15	37					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144062345	144062345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:144062345G>A	ENST00000056217.5	+	2	2757	c.2583G>A	c.(2581-2583)agG>agA	p.R861R		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	861					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					CCAGGGGGAGGAGCAGGAGCA	0.597000													15	134					0	0	1	0	0
WIPF1	7456	broad.mit.edu	37	2	175436545	175436545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:175436545C>T	ENST00000392547.2	-	5	1087	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000272746.5_Missense_Mutation_p.E330K|WIPF1_ENST00000409415.3_Missense_Mutation_p.E330K|AC018890.6_ENST00000412835.1_RNA|WIPF1_ENST00000359761.3_Missense_Mutation_p.E330K|WIPF1_ENST00000392546.2_Missense_Mutation_p.E330K|WIPF1_ENST00000409891.1_Missense_Mutation_p.E330K	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	330	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						CTTGGGGTTTCGTCATTGCCG	0.677000													5	58					0	0	1	0	0
RMDN2	151393	broad.mit.edu	37	2	38178625	38178625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:38178625C>T	ENST00000407257.1	+	2	414	c.267C>T	c.(265-267)tcC>tcT	p.S89S	RMDN2_ENST00000417700.2_Intron|RMDN2_ENST00000234195.3_Silent_p.S89S|RMDN2_ENST00000402091.3_Silent_p.S89S|RMDN2-AS1_ENST00000414365.2_RNA|RMDN2_ENST00000406384.1_Intron|RMDN2_ENST00000354545.2_Intron					regulator of microtubule dynamics 2																		GAAATGCTTCCCCTTACTGGC	0.363000													43	106					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130286970	130286970	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130286970G>A	ENST00000358511.6	+	5	1954	c.1923G>A	c.(1921-1923)atG>atA	p.M641I	COL6A6_ENST00000453409.2_Missense_Mutation_p.M641I	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	641	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCAGCAAAATGAAAACATTTA	0.413000													47	79					0	0	1	0	0
SLC17A7	57030	broad.mit.edu	37	19	49939943	49939943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49939943G>A	ENST00000221485.3	-	2	349	c.178C>T	c.(178-180)Cct>Tct	p.P60S	SLC17A7_ENST00000543531.1_Missense_Mutation_p.P48S|SLC17A7_ENST00000600601.1_5'UTR	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	60					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		TAGCGGCGAGGGAGGCCGAAG	0.647000													42	101					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51852422	51852422	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51852422G>A	ENST00000453097.2	+	7	1060	c.843G>A	c.(841-843)gtG>gtA	p.V281V	SLC4A8_ENST00000394856.1_Silent_p.V228V|SLC4A8_ENST00000514353.3_Silent_p.V228V|SLC4A8_ENST00000358657.3_Silent_p.V308V|SLC4A8_ENST00000535225.2_Silent_p.V228V	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	281					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		ATAGTCCTGTGGATTTAAGCA	0.408000													15	81					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7580655	7580655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7580655G>A	ENST00000379802.3	+	23	4573	c.4232G>A	c.(4231-4233)aGg>aAg	p.R1411K	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1411	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAAATAAAGAGGCTGAAGAAC	0.498000													32	52					0	0	1	0	0
LAPTM4B	55353	broad.mit.edu	37	8	98837319	98837319	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:98837319C>T	ENST00000445593.2	+	6	1494	c.814C>T	c.(814-816)Cga>Tga	p.R272*	LAPTM4B_ENST00000521545.2_Nonsense_Mutation_p.R181*	NM_018407.4	NP_060877.3	Q86VI4	LAP4B_HUMAN	lysosomal protein transmembrane 4 beta	325					transport	endomembrane system|integral to membrane	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	10	Breast(36;1.59e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.149)			GAACTGCTACCGATACATCAA	0.403000													9	88					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118629336	118629336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:118629336C>T	ENST00000336338.5	-	12	1634	c.1569G>A	c.(1567-1569)ctG>ctA	p.L523L		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	523						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CATGATAGTTCAGTAGGAGGG	0.378000													45	98					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139890104	139890104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139890104C>T	ENST00000303045.6	-	3	993	c.547G>A	c.(547-549)Gag>Aag	p.E183K	COL22A1_ENST00000435777.1_Missense_Mutation_p.E183K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	183	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCCAGCTCCTCCTTGAGTGCC	0.692000										HNSCC(7;0.00092)			11	24					0	0	1	0	0
PFKFB2	5208	broad.mit.edu	37	1	207228079	207228079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207228079C>T	ENST00000367080.3	+	2	141	c.17C>T	c.(16-18)tCc>tTc	p.S6F	PFKFB2_ENST00000545806.1_5'UTR|PFKFB2_ENST00000367079.2_Missense_Mutation_p.S6F|PFKFB2_ENST00000411990.2_5'UTR	NM_006212.2	NP_006203.2	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	6	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	20	Prostate(682;0.19)					GGGGCATCTTCCTCAGAACAG	0.423000													13	20					0	0	1	0	0
TMEM176A	55365	broad.mit.edu	37	7	150498668	150498668	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150498668C>T	ENST00000484928.1	+	2	611	c.30C>T	c.(28-30)gcC>gcT	p.A10A	TMEM176A_ENST00000004103.3_Silent_p.A10A|TMEM176A_ENST00000461345.1_Intron			Q96HP8	T176A_HUMAN	transmembrane protein 176A	10						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ATGAGATGGCCCCGGAGGCCC	0.607000													21	47					0	0	1	0	0
GPR155	151556	broad.mit.edu	37	2	175304647	175304647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:175304647C>T	ENST00000392552.2	-	15	2529	c.2291G>A	c.(2290-2292)cGa>cAa	p.R764Q	GPR155_ENST00000295500.4_Missense_Mutation_p.R764Q|GPR155_ENST00000392551.2_Missense_Mutation_p.R764Q|GPR155_ENST00000459996.1_5'UTR	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155	764	DEP.				intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						GACAATGTTTCGGATACAGAG	0.333000													28	88					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22078966	22078966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22078966G>A	ENST00000454243.2	-	5	1467	c.893C>T	c.(892-894)aCc>aTc	p.T298I	PHYHIP_ENST00000321613.3_Missense_Mutation_p.T298I	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	298										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		CTCCCCCAGGGTGCCCAGGGA	0.627000													29	100					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142634	48142634	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48142634G>A	ENST00000405493.2	-	11	1205	c.996C>T	c.(994-996)ggC>ggT	p.G332G	RAPGEF3_ENST00000549151.1_Silent_p.G332G|RAPGEF3_ENST00000548919.1_Silent_p.G332G|RAPGEF3_ENST00000389212.3_Silent_p.G374G|RAPGEF3_ENST00000171000.4_Silent_p.G332G|RAPGEF3_ENST00000395358.3_Silent_p.G374G|RAPGEF3_ENST00000449771.2_Silent_p.G374G	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	332					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GTCGGGAAGGGCCGGCGCCCT	0.597000													41	110					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45410266	45410266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45410266G>A	ENST00000332700.6	-	4	994	c.823C>T	c.(823-825)Cca>Tca	p.P275S		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	275						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GAAGGACATGGAGAAGGGAAA	0.493000													46	104					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55439064	55439064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55439064G>A	ENST00000446217.1	-	12	3376	c.2974C>T	c.(2974-2976)Ctg>Ttg	p.L992L	NLRP7_ENST00000592784.1_Silent_p.L964L|NLRP7_ENST00000340844.2_Intron|NLRP7_ENST00000588756.1_Silent_p.L964L|NLRP7_ENST00000448121.2_Silent_p.L936L|NLRP7_ENST00000328092.5_Silent_p.L936L|NLRP7_ENST00000590030.1_Intron			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	0							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CCCAGGTCCAGAGTTTCAAGC	0.463000													22	171					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179648970	179648970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179648970C>T	ENST00000589042.1	-	16	2826	c.2602G>A	c.(2602-2604)Gag>Aag	p.E868K	TTN_ENST00000342992.6_Missense_Mutation_p.E868K|TTN_ENST00000360870.5_Missense_Mutation_p.E868K|TTN_ENST00000460472.2_Missense_Mutation_p.E822K|TTN_ENST00000342175.6_Missense_Mutation_p.E822K|TTN_ENST00000359218.5_Missense_Mutation_p.E822K|TTN_ENST00000591111.1_Missense_Mutation_p.E868K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	868							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCTAGTCTCACTGGGCTTC	0.502000													30	59					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89259263	89259263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:89259263G>A	ENST00000336596.2	+	3	632	c.407G>A	c.(406-408)cGa>cAa	p.R136Q	EPHA3_ENST00000452448.2_Missense_Mutation_p.R136Q|EPHA3_ENST00000494014.1_Missense_Mutation_p.R136Q	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	136						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTGAAATTTCGAGAGCATCAG	0.418000										TSP Lung(6;0.00050)			33	168					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96745889	96745889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96745889G>A	ENST00000260682.6	+	8	1261	c.1249G>A	c.(1249-1251)Ggc>Agc	p.G417S		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	417			G -> D.		exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GGATGAAGGTGGCAATTTTAA	0.363000													54	109					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200143213	200143213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200143213C>T	ENST00000367362.3	+	8	1747	c.1501C>T	c.(1501-1503)Ctt>Ttt	p.L501F	NR5A2_ENST00000236914.3_Missense_Mutation_p.L455F|NR5A2_ENST00000544748.1_Missense_Mutation_p.L429F	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	501					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					ACAGCTACTTCTTCGACTACC	0.498000													16	30					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33696189	33696189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33696189C>T	ENST00000253193.7	+	5	715	c.513C>T	c.(511-513)ttC>ttT	p.F171F	LRP3_ENST00000592484.1_3'UTR	NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	171	LDL-receptor class A 1.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					CAGATGAGTTCCGCTGTGACA	0.662000													3	10					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168099318	168099318	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168099318C>T	ENST00000409195.1	+	9	1505	c.1416C>T	c.(1414-1416)tcC>tcT	p.S472S	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Silent_p.S472S|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.S250S	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	297					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TTTCCCAGTCCCCTGAACTGC	0.413000													43	75					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20045433	20045433	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20045433A>G	ENST00000343769.5	+	4	1697	c.1669A>G	c.(1669-1671)Ata>Gta	p.I557V	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	557						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						TACACATAAGATACTTCATAC	0.358000													23	46					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615651	179615651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179615651C>T	ENST00000360870.5	-	46	11698	c.11476G>A	c.(11476-11478)Gaa>Aaa	p.E3826K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9660							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTAGAATTTCACCATATAAA	0.348000													53	137					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11584065	11584065	+	Missense_Mutation	SNP	G	G	A	rs61744927		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11584065G>A	ENST00000294484.6	+	11	2567	c.2429G>A	c.(2428-2430)cGa>cAa	p.R810Q	PTCHD2_ENST00000389575.3_Missense_Mutation_p.R810Q	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	810					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AAGAAGAGGCGAGGCTCAGGG	0.652000													6	50					0	0	1	0	0
NACAP1	83955	broad.mit.edu	37	8	102381246	102381246	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:102381246G>A	ENST00000419462.1	+	0	658					NR_002182.1																						GTCAGTACCAGAGCTTGAAGA	0.517000													7	88					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14157367	14157367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14157367G>A	ENST00000263379.2	+	8	1203	c.1078G>A	c.(1078-1080)Gac>Aac	p.D360N		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	360	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						TCGAGATGGGGACCCCCTGGA	0.647000													31	100					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34528852	34528852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34528852G>A	ENST00000374012.3	+	17	2908	c.2779G>A	c.(2779-2781)Ggt>Agt	p.G927S	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	927					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GCTGGACAGAGGTGGAGAGGG	0.532000													41	89					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287627	16287627	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:16287627C>T	ENST00000343518.6	-	1	310	c.259G>A	c.(259-261)Gac>Aac	p.D87N		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	87										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						GCAGAATCGTCGTGGTCTCCA	0.597000													54	374					0	0	1	0	0
UPK3B	80761	broad.mit.edu	37	7	76141016	76141016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76141016C>T	ENST00000419923.2	+	2	668	c.443C>T	c.(442-444)cCg>cTg	p.P148L	UPK3B_ENST00000448265.3_Missense_Mutation_p.P148L|UPK3B_ENST00000443097.2_Missense_Mutation_p.P93L|UPK3B_ENST00000257632.5_Missense_Mutation_p.P148L|UPK3B_ENST00000394849.1_Missense_Mutation_p.P93L|UPK3B_ENST00000334348.3_Missense_Mutation_p.P93L			Q9BT76	UPK3B_HUMAN	uroplakin 3B	148					negative regulation of gene expression	integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(1)|skin(2)	8		Myeloproliferative disorder(862;0.204)				GCTGACATTCCGGCCTCCCCA	0.647000													4	20					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110402700	110402700	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110402700C>T	ENST00000378402.5	+	9	821	c.717C>T	c.(715-717)ttC>ttT	p.F239F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	239	IPT/TIG 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATGTCAGCTTCATCTTAGATA	0.264000										HNSCC(38;0.096)			4	5					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240286576	240286576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240286576C>T	ENST00000319653.9	+	2	1943	c.1713C>T	c.(1711-1713)ctC>ctT	p.L571L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	571					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGGGTCTTCTCCTTCCTTTTA	0.507000													30	85					0	0	1	0	0
CARD9	64170	broad.mit.edu	37	9	139264822	139264822	+	Missense_Mutation	SNP	C	C	T	rs143263677		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139264822C>T	ENST00000371732.5	-	6	1040	c.875G>A	c.(874-876)cGg>cAg	p.R292Q	CARD9_ENST00000371734.3_Missense_Mutation_p.R292Q|CARD9_ENST00000315908.7_Missense_Mutation_p.R292Q	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	292					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		CTGGTGGTCCCGCAGCGCCTG	0.682000													8	4					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145584116	145584116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145584116C>T	ENST00000532887.1	+	3	1547	c.964C>T	c.(964-966)Ccc>Tcc	p.P322S	SLC52A2_ENST00000329994.2_Missense_Mutation_p.P322S|SLC52A2_ENST00000402965.1_Missense_Mutation_p.P322S|SLC52A2_ENST00000527078.1_Missense_Mutation_p.P322S|SLC52A2_ENST00000540505.1_Missense_Mutation_p.P234S|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000530047.1_Missense_Mutation_p.P322S			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	322						integral to plasma membrane	receptor activity|riboflavin transporter activity										TGCTGCCAATCCCCTGGCCTG	0.662000													47	81					0	0	1	0	0
KRT5	3852	broad.mit.edu	37	12	52908793	52908793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52908793C>T	ENST00000252242.4	-	9	2096	c.1706G>A	c.(1705-1707)gGg>gAg	p.G569E		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	569	Ser-rich.|Tail.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTGCTACCCCCGCCACTGCC	0.622000													32	43					0	0	1	0	0
LCE3C	353144	broad.mit.edu	37	1	152573387	152573387	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152573387C>T	ENST00000333881.3	+	1	250	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_178434.2	NP_848521.1	Q5T5A8	LCE3C_HUMAN	late cornified envelope 3C	60					keratinization					lung(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0313)|Kidney(5;0.0367)		ACAGGCACTTCAGGTCCCATC	0.642000													39	35					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214228839	214228839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:214228839G>A	ENST00000413312.1	+	7	955	c.709G>A	c.(709-711)Gga>Aga	p.G237R	SPAG16_ENST00000447990.1_Missense_Mutation_p.G268R|SPAG16_ENST00000331683.5_Missense_Mutation_p.G268R|SPAG16_ENST00000272898.7_Missense_Mutation_p.G268R|SPAG16_ENST00000414961.2_3'UTR|SPAG16_ENST00000374309.3_Missense_Mutation_p.G174R			Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	268					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		ACTGCAAAGAGGACATAGTTA	0.284000													11	23					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141499573	141499573	+	Silent	SNP	C	C	T	rs56022585		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141499573C>T	ENST00000264952.2	+	2	1107	c.970C>T	c.(970-972)Ctg>Ttg	p.L324L		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	324	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						GAATGTGCTTCTGGATGACCT	0.582000													22	30					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	239990240	239990240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239990240G>A	ENST00000345617.3	-	23	3590	c.2799C>T	c.(2797-2799)ttC>ttT	p.F933F	HDAC4_ENST00000543185.1_Silent_p.F517F	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	933	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CCACGGCATCGAAGCCTGATG	0.597000													8	67					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46332449	46332449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46332449G>A	ENST00000245934.7	-	14	2008	c.1764C>T	c.(1762-1764)atC>atT	p.I588I		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	588					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GGCTGGCCAGGATCTTTATGC	0.632000													20	49					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509082	71509082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71509082G>A	ENST00000396073.3	+	9	2220	c.1939G>A	c.(1939-1941)Gag>Aag	p.E647K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	647					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AGACCAGAAGGAGATAGTCCC	0.443000													49	119					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98507826	98507826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98507826C>T	ENST00000359863.4	+	15	1707	c.1498C>T	c.(1498-1500)Cca>Tca	p.P500S	TRRAP_ENST00000355540.3_Missense_Mutation_p.P500S|TRRAP_ENST00000446306.3_Missense_Mutation_p.P500S	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	500	Pro-rich.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTCCCTCCCCAGCCCCTGT	0.662000													23	61					0	0	1	0	0
PARP6	56965	broad.mit.edu	37	15	72548855	72548855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72548855G>A	ENST00000569795.1	-	14	1763	c.1076C>T	c.(1075-1077)cCc>cTc	p.P359L	PARP6_ENST00000260376.7_Missense_Mutation_p.P359L|PARP6_ENST00000287196.9_Missense_Mutation_p.P359L|PARP6_ENST00000413097.2_5'UTR			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	359							NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						CACCACAGAGGGATAAGGCTC	0.468000													23	40					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81698078	81698078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:81698078G>A	ENST00000429644.2	-	5	1263	c.620C>T	c.(619-621)tCt>tTt	p.S207F	GBE1_ENST00000489715.1_Missense_Mutation_p.S166F	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	207					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TTCATGGGAAGAAATTCCCAC	0.333000									Glycogen Storage Disease, type IV				9	17					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141010029	141010029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:141010029C>T	ENST00000277549.5	+	42	5826	c.3257C>T	c.(3256-3258)cCt>cTt	p.P1086L	CACNA1B_ENST00000277551.2_Missense_Mutation_p.P1892L|CACNA1B_ENST00000371372.1_Missense_Mutation_p.P1892L|CACNA1B_ENST00000371363.1_Missense_Mutation_p.P1890L|CACNA1B_ENST00000371355.4_Missense_Mutation_p.P1893L|CACNA1B_ENST00000371357.1_Missense_Mutation_p.P1891L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1892					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTGTTCCACCCTCTGAAGGCC	0.607000													29	103					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14601461	14601461	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14601461G>A	ENST00000274217.3	+	4	378	c.256_splice	c.e4-1	p.R86_splice		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	86										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					TTGGTCCAGGGAACCTCAGTG	0.398000													27	77					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43351929	43351929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43351929G>A	ENST00000290650.4	-	8	1034	c.956C>T	c.(955-957)tCc>tTc	p.S319F	UBR1_ENST00000382177.2_Missense_Mutation_p.S319F	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	319					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GTTCATCCAGGAACCAAGACG	0.333000													14	100					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37725431	37725431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37725431C>T	ENST00000264741.5	+	18	2248	c.1992C>T	c.(1990-1992)ctC>ctT	p.L664L		NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	664					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TCTCCAACCTCGGAGATGATG	0.458000													20	31					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71025259	71025259	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71025259C>A	ENST00000393567.2	-	25	3976	c.3826G>T	c.(3826-3828)Gaa>Taa	p.E1276*		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1276								p.E1276*(1)|p.E1228*(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTTCTTAGTTCTTTTTCTTCA	0.473000													32	78					4.34311e-12	4.36316e-12	1	1	0
GCC2	9648	broad.mit.edu	37	2	109088468	109088468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:109088468C>T	ENST00000309863.6	+	6	3397	c.2683C>T	c.(2683-2685)Cat>Tat	p.H895Y		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	895					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						AAGTGAAATCCATAATGAAAA	0.294000													17	70					0	0	1	0	0
UBE2E2	7325	broad.mit.edu	37	3	23250314	23250314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:23250314G>A	ENST00000396703.1	+	2	304	c.124G>A	c.(124-126)Gag>Aag	p.E42K	UBE2E2_ENST00000425792.1_Missense_Mutation_p.E42K	NM_152653.3	NP_689866.1	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	42					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(2)	10						CAAGAAAAAGGAGGGAAAAAT	0.388000													16	50					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8200926	8200926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8200926G>A	ENST00000600128.1	-	13	1924	c.1510C>T	c.(1510-1512)Cgc>Tgc	p.R504C	FBN3_ENST00000601739.1_Missense_Mutation_p.R504C|FBN3_ENST00000270509.2_Missense_Mutation_p.R504C			Q75N90	FBN3_HUMAN	fibrillin 3	504	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TTGACACAGCGGCCCAGGTGA	0.632000													7	25					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158585167	158585167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158585167C>T	ENST00000368148.3	-	48	6807	c.6627G>A	c.(6625-6627)atG>atA	p.M2209I	SPTA1_ENST00000368147.3_Missense_Mutation_p.M2206I	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2209					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTGACGCTTCATCGCCTGGA	0.483000													52	120					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149493797	149493797	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149493797G>A	ENST00000378016.2	+	0	6793							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGCTCGGATGAGGAGGGCTG	0.642000													4	13					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144918897	144918897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:144918897C>T	ENST00000529945.1	-	6	2217	c.1778G>A	c.(1777-1779)cGa>cAa	p.R593Q	PDE4DIP_ENST00000369359.4_Missense_Mutation_p.R567Q|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.R430Q|PDE4DIP_ENST00000369351.3_Missense_Mutation_p.R430Q|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R430Q|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.R496Q|PDE4DIP_ENST00000369349.3_Missense_Mutation_p.R430Q|PDE4DIP_ENST00000313431.9_Missense_Mutation_p.R593Q|PDE4DIP_ENST00000479408.2_Missense_Mutation_p.R217Q|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R567Q			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	430					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCCTGGGTTCGAATCTCATT	0.438000			T	PDGFRB	MPD								106	896					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56127840	56127840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56127840G>A	ENST00000303039.3	+	1	150	c.118G>A	c.(118-120)Gca>Aca	p.A40T		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					GCTGACCATGGCAGGGAACCT	0.498000													49	114					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48385910	48385910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48385910C>T	ENST00000224600.4	-	2	3295	c.3182G>A	c.(3181-3183)aGg>aAg	p.R1061K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1061	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CACCAGCAGCCTGGAGACCTG	0.537000													38	114					0	0	1	0	0
ZNF157	7712	broad.mit.edu	37	X	47272290	47272290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:47272290C>T	ENST00000377073.3	+	4	904	c.818C>T	c.(817-819)cCc>cTc	p.P273L		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	273					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						GGGGAGAAACCCTATGAATGT	0.448000													20	11					0	0	1	0	0
LMBR1	64327	broad.mit.edu	37	7	156518469	156518469	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:156518469G>A	ENST00000353442.4	-	13	1292	c.1056C>T	c.(1054-1056)atC>atT	p.I352I	LMBR1_ENST00000359422.4_Silent_p.I200I|LMBR1_ENST00000461603.1_5'UTR|LMBR1_ENST00000354505.4_Silent_p.I393I|LMBR1_ENST00000540390.1_Silent_p.I331I	NM_022458.3	NP_071903.2	Q8WVP7	LMBR1_HUMAN	limb development membrane protein 1	352						integral to membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	18	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.208)		AAATCAAAATGATTTCAAGCG	0.403000													24	53					0	0	1	0	0
VASH2	79805	broad.mit.edu	37	1	213147299	213147299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:213147299C>T	ENST00000366968.4	+	8	1037	c.687C>T	c.(685-687)atC>atT	p.I229I	VASH2_ENST00000366967.2_Silent_p.I190I|VASH2_ENST00000517399.1_Silent_p.I294I|VASH2_ENST00000366966.2_Silent_p.I229I|VASH2_ENST00000271776.4_3'UTR|VASH2_ENST00000366965.2_Silent_p.I250I	NM_001136474.1	NP_001129946.1	Q86V25	VASH2_HUMAN	vasohibin 2	294					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		TCCTTCAGATCCTGAAACCTG	0.587000													17	29					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44639169	44639169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44639169C>T	ENST00000372330.3	+	3	438	c.419C>T	c.(418-420)gCc>gTc	p.A140V		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	140					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	ATTGACGACGCCTTTGCCCGC	0.617000													17	40					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210574720	210574720	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:210574720C>T	ENST00000360351.4	+	12	5321	c.4815C>T	c.(4813-4815)acC>acT	p.T1605T	MAP2_ENST00000447185.1_Silent_p.T1601T|MAP2_ENST00000199940.6_Silent_p.T306T|MAP2_ENST00000361559.4_Silent_p.T249T|MAP2_ENST00000392194.1_Silent_p.T249T|MAP2_ENST00000475600.1_3'UTR	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1605					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTCCTGGCACCCCACCAAGTT	0.562000													46	98					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52000608	52000608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52000608G>A	ENST00000291707.3	-	6	1552	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	SIGLEC12_ENST00000598614.1_Silent_p.F381F	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	499					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CTCACACAACGAAGATGATGC	0.572000													33	79					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104239109	104239109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104239109G>A	ENST00000374851.1	-	4	1413	c.266C>T	c.(265-267)tCa>tTa	p.S89L	TMEM246_ENST00000374848.3_Missense_Mutation_p.S89L|RP11-490D19.6_ENST00000424154.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000450109.1_RNA|TMEM246_ENST00000374847.1_Missense_Mutation_p.S89L			Q9BRR3	CI125_HUMAN	transmembrane protein 246	89						integral to membrane		p.S89L(1)									AATGGGCACTGAGCCATTGGC	0.577000													17	24					0	0	1	0	0
IMPAD1	54928	broad.mit.edu	37	8	57890620	57890620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57890620G>A	ENST00000262644.4	-	3	893	c.635C>T	c.(634-636)tCc>tTc	p.S212F		NM_017813.4	NP_060283.3	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	212						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				TGTATATTCGGAAAATGGCTT	0.338000													47	131					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168838897	168838897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168838897G>A	ENST00000464456.1	-	6	1715	c.515C>T	c.(514-516)tCg>tTg	p.S172L	MECOM_ENST00000433243.2_Missense_Mutation_p.S173L|MECOM_ENST00000460814.1_Missense_Mutation_p.S172L|MECOM_ENST00000392736.3_Missense_Mutation_p.S172L|MECOM_ENST00000472280.1_Missense_Mutation_p.S173L|MECOM_ENST00000264674.3_Missense_Mutation_p.S237L|MECOM_ENST00000468789.1_Missense_Mutation_p.S172L|MECOM_ENST00000494292.1_Missense_Mutation_p.S360L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity	p.S172L(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GAGGCCCGACGAAGTGGCAAA	0.552000													13	59					0	0	1	0	0
SLC29A2	3177	broad.mit.edu	37	11	66136562	66136562	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66136562G>A	ENST00000357440.2	-	4	612	c.384C>T	c.(382-384)tcC>tcT	p.S128S	SLC29A2_ENST00000311161.7_Silent_p.S128S|SLC29A2_ENST00000546034.1_Silent_p.S128S|SLC29A2_ENST00000544554.1_Silent_p.S128S	NM_001532.2	NP_001523.2	Q14542	S29A2_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 2	128					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			breast(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10						CCATGGTGATGGAGAAGAAGG	0.607000													3	5					0	0	1	0	0
ZNF675	171392	broad.mit.edu	37	19	23836763	23836763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23836763G>A	ENST00000359788.4	-	4	1140	c.972C>T	c.(970-972)tcC>tcT	p.S324S	ZNF675_ENST00000601935.1_Intron|ZNF675_ENST00000596211.1_Intron|ZNF675_ENST00000600313.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	324					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TAAGGGTTGAGGATTGGGTAA	0.368000													15	85					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49001530	49001530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49001530C>T	ENST00000600059.1	-	11	3023	c.2796G>A	c.(2794-2796)ggG>ggA	p.G932G	LMTK3_ENST00000270238.3_Silent_p.G961G					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTCTCTGGTCCCCGTTCTCCA	0.642000													25	52					0	0	1	0	0
CCDC81	60494	broad.mit.edu	37	11	86126188	86126188	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:86126188C>T	ENST00000278487.3	+	12	1808	c.729C>T	c.(727-729)ccC>ccT	p.P243P	CCDC81_ENST00000528728.1_Silent_p.P243P|CCDC81_ENST00000445632.2_Silent_p.P508P|CCDC81_ENST00000354755.1_Silent_p.P418P			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	508										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				CCTCTGAGCCCATCTTTGGTA	0.458000													21	81					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013176	107013176	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107013176G>A	ENST00000390625.2	-	0	198																											AGCTGTACAGGAGAGTCTCAG	0.547000													26	85					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169108548	169108548	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169108548T>G	ENST00000359299.3	+	12	1124	c.938T>G	c.(937-939)cTg>cGg	p.L313R		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	313							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		AAGAAAGCACTGCTTGCCATC	0.338000													17	57					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247768993	247768993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247768993C>T	ENST00000320002.2	+	1	138	c.106C>T	c.(106-108)Ctc>Ttc	p.L36F	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTTCTTCTACCTCCTGACCCT	0.443000													68	176					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18705913	18705913	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18705913C>T	ENST00000406451.3	+	12	1686	c.1536C>T	c.(1534-1536)gaC>gaT	p.D512D	HDAC9_ENST00000417496.2_Silent_p.D510D|HDAC9_ENST00000441542.2_Silent_p.D515D|HDAC9_ENST00000432645.2_Silent_p.D512D|HDAC9_ENST00000401921.1_Silent_p.D471D|HDAC9_ENST00000406072.1_Silent_p.D499D|HDAC9_ENST00000428307.2_Silent_p.D468D|HDAC9_ENST00000456174.2_Silent_p.D484D|HDAC9_ENST00000524023.1_Silent_p.D435D|HDAC9_ENST00000405010.3_Silent_p.D512D	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	512					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TTCAGGGGGACCAGGCGATGC	0.537000											OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	150					0	0	1	0	0
DRAM1	55332	broad.mit.edu	37	12	102302023	102302023	+	Silent	SNP	C	C	T	rs61748065		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102302023C>T	ENST00000258534.8	+	4	841	c.402C>T	c.(400-402)gtC>gtT	p.V134V	DRAM1_ENST00000544152.1_Intron	NM_018370.2	NP_060840.2	Q8N682	DRAM1_HUMAN	DNA-damage regulated autophagy modulator 1	134					apoptosis|autophagy	integral to membrane|lysosomal membrane		p.V28V(2)		central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)	12						TCTGTGGTGTCGTGTACACGC	0.498000													17	120					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96944880	96944880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96944880G>A	ENST00000267584.4	+	15	1678	c.1634G>A	c.(1633-1635)gGg>gAg	p.G545E		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	545					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		ATCGTGGCGGGGACCCACTAC	0.502000													27	75					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39447062	39447062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39447062G>A	ENST00000280481.7	+	17	8383	c.8167G>A	c.(8167-8169)Gaa>Aaa	p.E2723K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2723					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCCAGAGGCTGAACTTCAAGG	0.403000													18	57					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	140990874	140990874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:140990874C>T	ENST00000389484.3	-	91	14652	c.13681G>A	c.(13681-13683)Gta>Ata	p.V4561I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4561					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTGCATATACCGGATTGGAG	0.323000										TSP Lung(27;0.18)			18	45					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	868150	868150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:868150G>A	ENST00000325464.1	-	16	2735	c.2585C>T	c.(2584-2586)cCc>cTc	p.P862L	MED16_ENST00000312090.6_3'UTR|MED16_ENST00000395808.3_3'UTR|MED16_ENST00000269814.4_3'UTR|MED16_ENST00000589119.1_Missense_Mutation_p.P862L	NM_005481.2	NP_005472.2	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	862					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGGTCCTGGGAGAGTGGTG	0.682000													5	17					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26918769	26918769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26918769G>A	ENST00000321765.5	-	4	1716	c.1384C>T	c.(1384-1386)Cct>Tct	p.P462S		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	462					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					TCTGGGTGAGGGACAGCCAGC	0.542000													35	54					0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76627229	76627229	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76627229C>T	ENST00000264917.5	+	5	698	c.653C>T	c.(652-654)tCg>tTg	p.S218L	PDE8B_ENST00000340978.3_Missense_Mutation_p.S218L|PDE8B_ENST00000346042.3_Missense_Mutation_p.S218L|PDE8B_ENST00000333194.4_Missense_Mutation_p.S218L|PDE8B_ENST00000342343.4_Missense_Mutation_p.S198L	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	218					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TGCTGCAGATCGGATGACCAT	0.502000													44	166					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300136	18300136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18300136G>A	ENST00000441493.2	-	26	5643	c.5291C>T	c.(5290-5292)cCc>cTc	p.P1764L		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1764						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CCCGCTGGAGGGGGTGCTGGG	0.652000													7	21					0	0	1	0	0
MCHR1	2847	broad.mit.edu	37	22	41077897	41077897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41077897G>A	ENST00000249016.4	+	2	1930	c.1234G>A	c.(1234-1236)Gct>Act	p.A412T	MCHR1_ENST00000381433.2_Missense_Mutation_p.A286T|MCHR1_ENST00000498400.1_3'UTR	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	412					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						CGCTCAGACGGCTGACGAGGA	0.607000													11	86					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898953	36898953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36898953G>A	ENST00000301807.6	-	12	2375	c.478C>T	c.(478-480)Ctt>Ttt	p.L160F	TRANK1_ENST00000429976.2_Missense_Mutation_p.L710F|TRANK1_ENST00000428977.2_Missense_Mutation_p.L160F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	710					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GAGCTCTGAAGACAGTCCTCT	0.557000													18	50					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17488005	17488005	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17488005G>A	ENST00000252590.4	-	1	154	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	31						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TGAGGGAGACGAAGAGGAAGA	0.607000													31	75					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61587119	61587119	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61587119G>A	ENST00000238508.3	+	5	529	c.470G>A	c.(469-471)tGg>tAg	p.W157*		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				ATCAACTCTTGGGTTGAAAGA	0.393000													28	77					0	0	1	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54639208	54639208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54639208C>T	ENST00000230640.5	+	8	1085	c.831C>T	c.(829-831)gtC>gtT	p.V277V	SKIV2L2_ENST00000545714.1_Silent_p.V176V	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	277	Helicase ATP-binding.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				CTGATAACGTCCACTATGTCT	0.353000													29	93					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39645728	39645728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39645728C>T	ENST00000265708.4	-	9	788	c.685G>A	c.(685-687)Gag>Aag	p.E229K	ADAM2_ENST00000347580.4_Missense_Mutation_p.E210K|ADAM2_ENST00000521880.1_Missense_Mutation_p.E229K|ADAM2_ENST00000379853.2_Intron	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	229	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ATCCAAAGCTCCAATGAAGAC	0.274000													17	86					0	0	1	0	0
RHBG	57127	broad.mit.edu	37	1	156351651	156351651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156351651G>A	ENST00000400992.2	+	6	1167	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	RHBG_ENST00000368246.2_Missense_Mutation_p.E299K|RHBG_ENST00000368249.1_Missense_Mutation_p.E299K|RHBG_ENST00000537040.1_Missense_Mutation_p.E137K|RHBG_ENST00000255013.3_Missense_Mutation_p.E230K|RHBG_ENST00000451864.2_Intron			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	299					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					GACCTCAAGTGAAATGATGCT	0.557000													24	66					0	0	1	0	0
NIM1K	167359	broad.mit.edu	37	5	43280253	43280253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:43280253G>A	ENST00000512796.1	+	4	2232	c.733G>A	c.(733-735)Gag>Aag	p.E245K	NIM1_ENST00000326035.2_Missense_Mutation_p.E245K			Q8IY84	NIM1_HUMAN		245	Protein kinase.						ATP binding|magnesium ion binding|protein serine/threonine kinase activity										CTTCCGGGACGAGCACTACAT	0.527000													34	79					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142643391	142643391	+	Missense_Mutation	SNP	C	C	T	rs61729041		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142643391C>T	ENST00000355265.2	-	11	1691	c.1217G>A	c.(1216-1218)cGa>cAa	p.R406Q	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	406			R -> Q (in KEL26 antigen).		proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					CTTCATCCATCGTGGGCGGGC	0.562000													12	23					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52129363	52129363	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52129363C>T	ENST00000222107.4	-	8	1524	c.1386G>A	c.(1384-1386)gtG>gtA	p.V462V	SIGLEC5_ENST00000429354.3_Silent_p.V462V|SIGLEC5_ENST00000534261.2_Silent_p.V462V|SIGLEC5_ENST00000599649.1_Silent_p.V462V|SIGLEC5_ENST00000570106.2_Silent_p.V462V			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	462					cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TGCGGGCTTTCACTCTAAGGA	0.522000													9	72					0	0	1	0	0
CHRM1	1128	broad.mit.edu	37	11	62677518	62677518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62677518C>T	ENST00000306960.3	-	2	1596	c.1055G>A	c.(1054-1056)cGg>cAg	p.R352Q	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	352					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	GAAGGTCTTCCGCTTGGCCAG	0.597000													11	30					0	0	1	0	0
FUT4	2526	broad.mit.edu	37	11	94277910	94277910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94277910C>T	ENST00000358752.2	+	1	894	c.611C>T	c.(610-612)gCc>gTc	p.A204V		NM_002033.3	NP_002024.1	P22083	FUT4_HUMAN	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	204					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGCGATAGCGCCCCGAGGCCG	0.741000													3	8					0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978476	10978476	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10978476G>A	ENST00000240619.2	-	1	481	c.393C>T	c.(391-393)ttC>ttT	p.F131F		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	131					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						ATACTATCATGAAGGGAAGAA	0.348000													22	45					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331096	85331096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85331096C>T	ENST00000440886.1	-	1	746	c.708G>A	c.(706-708)aaG>aaA	p.K236K	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Silent_p.K236K			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	236					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						TCTTCATTAGCTTCATGGGTG	0.498000													17	21					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160114869	160114869	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:160114869G>A	ENST00000327245.5	-	5	1059	c.213C>T	c.(211-213)acC>acT	p.T71T	ATP10B_ENST00000518411.1_5'UTR|CTC-529G1.1_ENST00000524198.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	71					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGTTGTGCAGGTTCTGTTGC	0.473000													47	152					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735225	140735225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140735225C>T	ENST00000571252.1	+	1	458	c.458C>T	c.(457-459)cCt>cTt	p.P153L	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGATTTCCTCTTCCTGAA	0.458000													7	35					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155790444	155790444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155790444G>A	ENST00000437809.1	-	6	1089	c.967C>T	c.(967-969)Cct>Tct	p.P323S	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Missense_Mutation_p.P323S|GON4L_ENST00000368331.1_Missense_Mutation_p.P323S|GON4L_ENST00000271883.5_Missense_Mutation_p.P323S			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	323					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTCATTTTAGGCTCCTAAGGA	0.393000													21	57					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716834	13716834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13716834G>A	ENST00000279593.3	-	13	3547	c.3338C>T	c.(3337-3339)cCg>cTg	p.P1113L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1113					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGAGCGGGGCGGTCGGCGACG	0.607000													21	46					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81914540	81914540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81914540C>T	ENST00000359376.3	+	8	888	c.674C>T	c.(673-675)tCg>tTg	p.S225L		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	225					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						AAAAAGGATTCGTCCGTGTTC	0.507000													24	94					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233397849	233397849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233397849G>A	ENST00000258229.8	-	3	656	c.422C>T	c.(421-423)cCc>cTc	p.P141L	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	141						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GCAGCGGAGGGGAGGCGTGGA	0.488000													16	163					0	0	1	0	0
MTHFSD	64779	broad.mit.edu	37	16	86575416	86575416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:86575416G>A	ENST00000322911.6	-	7	615	c.565C>T	c.(565-567)Cct>Tct	p.P189S	MTHFSD_ENST00000543303.2_Missense_Mutation_p.P189S|MTHFSD_ENST00000360900.6_Missense_Mutation_p.P190S|MTHFSD_ENST00000381214.5_Missense_Mutation_p.P190S|MTHFSD_ENST00000546093.1_Missense_Mutation_p.P27S	NM_001159377.1|NM_022764.2	NP_001152849.1|NP_073601.2	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	190					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						AGCTCTTCAGGGATGTCCACG	0.592000													6	34					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45711088	45711088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45711088C>T	ENST00000291582.5	+	8	1117	c.990C>T	c.(988-990)atC>atT	p.I330I	AIRE_ENST00000355347.4_Silent_p.I123I|AIRE_ENST00000329347.4_Silent_p.I123I	NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	330					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		TCCGGGAGATCCCCAGGTGAG	0.701000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				8	24					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156917205	156917205	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156917205G>A	ENST00000368194.3	-	26	3418	c.2379C>T	c.(2377-2379)ctC>ctT	p.L793L	ARHGEF11_ENST00000315174.8_Silent_p.L169L|ARHGEF11_ENST00000361409.2_Silent_p.L753L	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	753	DH.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCAGGACCCGGAGTGTGCGCA	0.562000													15	26					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24775279	24775279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24775279G>A	ENST00000221166.5	+	3	2693	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	NEFM_ENST00000437366.2_Intron|NEFM_ENST00000521540.1_Intron|NEFM_ENST00000433454.2_Silent_p.E261E|NEFM_ENST00000518131.1_Intron			P07197	NFM_HUMAN	neurofilament, medium polypeptide	637	6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK].|Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CAGTGGAAGAGAAAGGCAAGT	0.507000													34	115					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272394	52272394	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52272394C>T	ENST00000598776.1	+	2	1255	c.483C>T	c.(481-483)ttC>ttT	p.F161F	FPR2_ENST00000340023.6_Silent_p.F161F|FPR2_ENST00000598953.1_Silent_p.F161F	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	161					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						TGCCAGTTTTCCTCTTTTTGA	0.517000													46	86					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69046410	69046410	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:69046410G>A	ENST00000288368.4	+	32	4160	c.3883G>A	c.(3883-3885)Gaa>Aaa	p.E1295K		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1295					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CAACAGCAAGGAAAATGAGAT	0.498000													36	63					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129913387	129913387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129913387C>T	ENST00000368654.3	-	7	1660	c.1285G>A	c.(1285-1287)Gat>Aat	p.D429N	MKI67_ENST00000368653.3_Intron	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	429					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ACTTCCACATCTGTAGGAATA	0.428000													40	105					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17886947	17886947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17886947C>T	ENST00000594202.1	+	16	1438	c.1159C>T	c.(1159-1161)Ctc>Ttc	p.L387F	FCHO1_ENST00000600676.1_Missense_Mutation_p.L387F|FCHO1_ENST00000597512.1_Missense_Mutation_p.L394F|FCHO1_ENST00000252771.7_Missense_Mutation_p.L387F|FCHO1_ENST00000595033.1_Missense_Mutation_p.L337F|FCHO1_ENST00000596951.1_Missense_Mutation_p.L387F|FCHO1_ENST00000596536.1_Missense_Mutation_p.L387F|FCHO1_ENST00000539407.1_Missense_Mutation_p.L387F|FCHO1_ENST00000389133.4_Missense_Mutation_p.L387F	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	387										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CGCGGGCAGCCTCATCCTTCC	0.672000													10	142					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50383660	50383660	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50383660G>A	ENST00000221543.5	+	4	618		c.e4+1		TBC1D17_ENST00000535102.2_Splice_Site|TBC1D17_ENST00000598789.1_Splice_Site	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17							intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCCACGAGAGGTAGGCTGAGG	0.597000													18	31					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156631964	156631964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156631964C>T	ENST00000296518.7	+	6	856	c.647C>T	c.(646-648)cCc>cTc	p.P216L	GUCY1A3_ENST00000511108.1_Missense_Mutation_p.P216L|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.P216L|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.P216L|GUCY1A3_ENST00000393832.3_5'UTR|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.P216L|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.P216L			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	216					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTGATTCTTCCCGGCATCATA	0.463000													43	92					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43585168	43585168	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43585168C>T	ENST00000406487.1	-	2	393	c.295G>A	c.(295-297)Gaa>Aaa	p.E99K		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	99	Ig-like V-type.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				TATGCTGTTTCTCGTCCACTA	0.453000													123	341					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760614	19760614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19760614G>A	ENST00000357324.6	-	18	2497	c.2471C>T	c.(2470-2472)cCc>cTc	p.P824L	ATP13A1_ENST00000291503.5_Missense_Mutation_p.P706L	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	824					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CAGCTGCTGGGGGTCGGTGGC	0.687000													7	40					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62376529	62376529	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62376529G>A	ENST00000394773.2	-	7	1141	c.834C>T	c.(832-834)gcC>gcT	p.A278A	EML3_ENST00000278845.4_Silent_p.A279A|EML3_ENST00000494176.2_Silent_p.A250A|EML3_ENST00000531557.1_Silent_p.A61A|EML3_ENST00000529309.1_Silent_p.A278A	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	278						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CCACCACACAGGCGATAAAGT	0.607000													70	185					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32041710	32041710	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32041710G>A	ENST00000375244.3	-	12	4596	c.4395C>T	c.(4393-4395)acC>acT	p.T1465T	TNXB_ENST00000375247.2_Silent_p.T1465T			P22105	TENX_HUMAN	tenascin XB	1552	Fibronectin type-III 7.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TGGCTGGAGGGGTCTCTTCTT	0.522000													9	13					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128482973	128482973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128482973G>A	ENST00000325888.8	+	16	2776	c.2515G>A	c.(2515-2517)Ggc>Agc	p.G839S	FLNC_ENST00000346177.6_Missense_Mutation_p.G839S	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	839					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ACCAGGGGCGGGCCGCTACAC	0.592000													4	46					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168107590	168107590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168107590C>T	ENST00000409195.1	+	9	9777	c.9688C>T	c.(9688-9690)Cgt>Tgt	p.R3230C	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R3230C|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.R3008C	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3055					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATAGAAACTCGTGGTAGGGA	0.448000													30	74					0	0	1	0	0
GDF6	392255	broad.mit.edu	37	8	97157007	97157007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:97157007C>T	ENST00000287020.5	-	2	1251	c.1152G>A	c.(1150-1152)gaG>gaA	p.E384E		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	384					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					CGCATACACCCTCGCAGTGAT	0.637000													18	24					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102869555	102869555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102869555G>A	ENST00000456098.1	-	2	304	c.86C>T	c.(85-87)tCc>tTc	p.S29F	IGF1_ENST00000307046.8_Missense_Mutation_p.S29F|IGF1_ENST00000392904.1_Missense_Mutation_p.S29F|IGF1_ENST00000424202.2_Missense_Mutation_p.S13F|IGF1_ENST00000337514.6_Missense_Mutation_p.S29F	NM_001111283.1	NP_001104753.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	29					anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						GAGATGCGAGGAGGACATGGT	0.597000													4	24					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142479923	142479923	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142479923G>A	ENST00000603901.1	+	0	55					NR_001296.3																						TGTCCCCTTTGATGATGATGA	0.547000													75	270					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138378212	138378212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:138378212C>T	ENST00000409968.1	+	20	3893	c.3715C>T	c.(3715-3717)Ccc>Tcc	p.P1239S	THSD7B_ENST00000272643.3_Missense_Mutation_p.P1242S|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.P1211S					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATGAGCATTCCCTGCTTGGT	0.468000													70	135					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85711043	85711043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85711043C>T	ENST00000322366.6	-	22	3912	c.3505G>A	c.(3505-3507)Gag>Aag	p.E1169K	WDFY3_ENST00000295888.4_Missense_Mutation_p.E1169K			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1169						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AATGAGGACTCTTCACTAAAA	0.388000													18	53					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515802	140515802	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140515802C>T	ENST00000231134.5	+	1	1003	c.786C>T	c.(784-786)gtC>gtT	p.V262V		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		262	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTTAGTTGTCGTTGTCTCCG	0.453000													130	258					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78594328	78594328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:78594328C>T	ENST00000397909.2	+	38	6964	c.6791C>T	c.(6790-6792)tCt>tTt	p.S2264F	NAV3_ENST00000266692.7_Missense_Mutation_p.S2065F|NAV3_ENST00000536525.2_Missense_Mutation_p.S2242F|NAV3_ENST00000541270.1_Missense_Mutation_p.S94F|NAV3_ENST00000228327.6_Missense_Mutation_p.S2242F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2264						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TGGAACTATTCTTTAGTACCT	0.338000										HNSCC(70;0.22)			36	69					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83610752	83610752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83610752G>A	ENST00000265362.3	-	14	1851	c.1537C>T	c.(1537-1539)Cct>Tct	p.P513S	SEMA3A_ENST00000436949.1_Missense_Mutation_p.P513S	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	513	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CGGTGTAAAGGGAGCTGGGCA	0.463000													6	50					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21145600	21145600	+	Silent	SNP	C	C	T	rs141077519		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21145600C>T	ENST00000261383.3	-	7	1061	c.1062G>A	c.(1060-1062)ctG>ctA	p.L354L	DNAH3_ENST00000415178.1_Silent_p.L354L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	354	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACAGTTCTTTCAGCCTGAGCA	0.527000													29	102					0	0	1	0	0
SLC35G2	80723	broad.mit.edu	37	3	136573347	136573347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:136573347G>A	ENST00000446465.2	+	2	673	c.45G>A	c.(43-45)gtG>gtA	p.V15V	RP11-85F14.5_ENST00000461864.1_RNA|RP11-85F14.5_ENST00000470236.1_RNA|RP11-85F14.5_ENST00000474250.1_RNA|SLC35G2_ENST00000393079.3_Silent_p.V15V	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	15						Golgi apparatus|integral to membrane											AAAAACGGGTGAAAATACATC	0.328000													73	149					0	0	1	0	0
GPALPP1	55425	broad.mit.edu	37	13	45580398	45580398	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:45580398C>T	ENST00000361121.2	+	3	318	c.283C>T	c.(283-285)Ctt>Ttt	p.L95F	KIAA1704_ENST00000379151.4_Missense_Mutation_p.L95F|RP11-321C24.1_ENST00000437748.2_lincRNA|KIAA1704_ENST00000357537.3_5'UTR			Q8IXQ4	K1704_HUMAN		95										breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|prostate(2)|skin(1)	12		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		TGGACCAGCCCTTCCTCCTGG	0.333000													67	255					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237400	29237400	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:29237400C>T	ENST00000382535.3	+	2	1284	c.915C>T	c.(913-915)tcC>tcT	p.S305S	FOXG1_ENST00000313071.4_Silent_p.S305S			P55316	FOXG1_HUMAN	forkhead box G1	305				RAGSLYWPMSPFLSLHHPR -> APAPSTGPCRPSCPCTTP (in Ref. 1; CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GCGCCGGCTCCCTCTACTGGC	0.701000													41	131					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803193	54803193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54803193C>T	ENST00000391745.1	-	8	851	c.535G>A	c.(535-537)Gat>Aat	p.D179N	LILRA3_ENST00000391744.3_Intron|LILRA3_ENST00000251390.3_Missense_Mutation_p.D162N					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGTGTTCATCTTCTCCTTCC	0.577000													68	105					0	0	1	0	0
KRTAP12-1	353332	broad.mit.edu	37	21	46102014	46102014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46102014C>T	ENST00000391617.1	-	1	64	c.25G>A	c.(25-27)Ggc>Agc	p.G9S	TSPEAR_ENST00000323084.4_Intron	NM_181686.1	NP_859014.1	P59990	KR121_HUMAN	keratin associated protein 12-1	9						keratin filament				kidney(1)|large_intestine(1)|lung(1)|skin(2)	5						GGCTGGCAGCCCGAGGAGCAG	0.657000													19	46					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417399	150417399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150417399C>T	ENST00000307194.5	+	3	447	c.307C>T	c.(307-309)Cac>Tac	p.H103Y		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGAGAGAGGTCACTGCTACCT	0.642000													15	49					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83095854	83095854	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83095854C>T	ENST00000307792.3	-	4	867	c.400G>A	c.(400-402)Ggt>Agt	p.G134S	SEMA3E_ENST00000427262.1_Missense_Mutation_p.G74S	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	134	Sema.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GCTCCAGTACCACAGGTCAGA	0.383000													26	58					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57596994	57596994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57596994C>T	ENST00000243077.3	+	69	11208	c.10742C>T	c.(10741-10743)tCc>tTc	p.S3581F		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3581	LDL-receptor class A 27.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGTGAGTTCTCCTGTGCCAAC	0.667000													7	11					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35332721	35332721	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35332721G>A	ENST00000373347.1	-	11	2917	c.2649C>T	c.(2647-2649)atC>atT	p.I883I	DLGAP3_ENST00000235180.4_Silent_p.I883I			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	883					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane		p.I883M(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				TCACATCCTCGATGGAGAGCT	0.582000											OREG0013353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	128					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8654132	8654132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8654132C>T	ENST00000270328.4	-	17	2418	c.2152G>A	c.(2152-2154)Ggg>Agg	p.G718R	ADAMTS10_ENST00000595838.1_Missense_Mutation_p.G205R|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.G718R			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	718	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TCACCGGCCCCAGGTGAGGCT	0.637000													18	54					0	0	1	0	0
GK5	256356	broad.mit.edu	37	3	141904627	141904627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141904627G>A	ENST00000544571.1	-	10	955	c.825C>T	c.(823-825)gtC>gtT	p.V275V	GK5_ENST00000392993.2_Intron			Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	0					glycerol metabolic process		ATP binding|glycerol kinase activity			kidney(1)|large_intestine(1)|lung(7)|urinary_tract(1)	10						CATATCCAGGGACCTTTAACT	0.323000													10	20					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42116018	42116018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42116018C>T	ENST00000457542.2	+	29	4258	c.3972C>T	c.(3970-3972)ttC>ttT	p.F1324F	MAPKBP1_ENST00000221214.6_Silent_p.F1207F|MAPKBP1_ENST00000260357.7_Silent_p.F1163F|MAPKBP1_ENST00000456763.2_Silent_p.F1330F|MAPKBP1_ENST00000514566.1_Intron	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	1330										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AGCCTGGCTTCCCGGTGGGCC	0.612000													49	96					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120764309	120764309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120764309G>A	ENST00000273666.6	+	5	668	c.397G>A	c.(397-399)Gat>Aat	p.D133N	STXBP5L_ENST00000471454.1_Missense_Mutation_p.D133N|STXBP5L_ENST00000492541.1_Missense_Mutation_p.D133N|STXBP5L_ENST00000497029.1_Missense_Mutation_p.D133N|STXBP5L_ENST00000472879.1_Missense_Mutation_p.D133N	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	133					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		AAGTTCAGATGATACACTTCA	0.348000													17	169					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4968016	4968016	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4968016G>A	ENST00000380373.2	-	1	340	c.315C>T	c.(313-315)ttC>ttT	p.F105F	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCCATGAATGAAGAATTCCT	0.443000													53	154					0	0	1	0	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229394	90229394	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90229394G>A	ENST00000390278.2	+	0	234																											CTTCCTCTATGATGCAAAAGA	0.488000													32	76					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72509694	72509694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72509694G>A	ENST00000373208.1	+	16	2389	c.2389G>A	c.(2389-2391)Gaa>Aaa	p.E797K	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.E794K	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	794	Spacer.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						GGATGCCAAGGAAAGCCTCAA	0.642000													13	63					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125192248	125192248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125192248C>T	ENST00000431078.1	+	5	1081	c.717C>T	c.(715-717)gcC>gcT	p.A239A		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	239	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGAGGCTCGCCCTACACCTCA	0.537000													4	15					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207651394	207651394	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207651394C>T	ENST00000367057.3	+	16	3256	c.3067C>T	c.(3067-3069)Ccc>Tcc	p.P1023S	CR2_ENST00000367059.3_Missense_Mutation_p.P902S|CR2_ENST00000458541.2_Missense_Mutation_p.P937S|CR2_ENST00000367058.3_Missense_Mutation_p.P964S	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	964					complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						ATGGAACCCTCCCCTGGCGGT	0.542000													5	31					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	457111	457111	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:457111C>T	ENST00000512944.1	+	5	1343	c.1154C>T	c.(1153-1155)tCc>tTc	p.S385F	EXOC3_ENST00000315013.5_Missense_Mutation_p.S385F	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	396					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACGTACATGTCCACGCTCACT	0.587000													5	25					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40590106	40590106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:40590106G>A	ENST00000342449.3	-	31	3709	c.3631C>T	c.(3631-3633)Cga>Tga	p.R1211*	BRWD1_ENST00000380800.3_Nonsense_Mutation_p.R1211*|BRWD1_ENST00000333229.2_Nonsense_Mutation_p.R1211*|BRWD1-IT1_ENST00000435608.1_RNA	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1211	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AGTCTCATTCGAATTGTGTAA	0.363000													17	58					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21911671	21911671	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:21911671G>A	ENST00000581223.2	+	0	2396					NR_027084.1																						GCCAACCAAAGTCAAAGAAGA	0.453000													2	0					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136062736	136062736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:136062736G>A	ENST00000383202.2	-	30	3640	c.3384C>T	c.(3382-3384)ccC>ccT	p.P1128P	STAG1_ENST00000536929.1_Silent_p.P712P|STAG1_ENST00000236698.5_Silent_p.P1128P|STAG1_ENST00000434713.2_Silent_p.P868P	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1128					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GGTCTCCCATGGGCCGACTGT	0.463000													26	84					0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41032495	41032495	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41032495C>T	ENST00000380620.3	+	5	601	c.9C>T	c.(7-9)ttC>ttT	p.F3F	B3GALT5_ENST00000398714.2_Silent_p.F3F|B3GALT5_ENST00000380618.1_Silent_p.F3F|AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000343118.4_Silent_p.F3F			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	3					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				AGATGGCTTTCCCGAAGATGA	0.423000													34	154					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84363139	84363139	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84363139C>T	ENST00000509231.1	-	1	915	c.836G>A	c.(835-837)tGg>tAg	p.W279*	SATL1_ENST00000395409.3_Nonsense_Mutation_p.W92*|SATL1_ENST00000332921.5_Nonsense_Mutation_p.W92*			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	92	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						GCTTGCACTCCATTGGTTCAT	0.438000													13	51					0	0	1	0	0
SH3GL3	6457	broad.mit.edu	37	15	84257443	84257443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84257443G>A	ENST00000324537.5	+	11	1274	c.782G>A	c.(781-783)cGa>cAa	p.R261Q	SH3GL3_ENST00000427482.2_Missense_Mutation_p.R253Q|SH3GL3_ENST00000535412.1_Missense_Mutation_p.R253Q|SH3GL3_ENST00000434347.1_Missense_Mutation_p.R261Q			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	253					central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						GTCCCCAGACGAGAATACAAG	0.458000													14	79					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2026061	2026061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2026061C>T	ENST00000568546.1	+	12	1262	c.1134C>T	c.(1132-1134)atC>atT	p.I378I		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	378					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						TCTCAGATATCGTCCTGGCCC	0.642000													50	116					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39978641	39978641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39978641G>A	ENST00000321562.4	+	10	1834	c.1730G>A	c.(1729-1731)cGg>cAg	p.R577Q	FKBP10_ENST00000544340.1_Missense_Mutation_p.R350Q	NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	577	EF-hand 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GACGAGGAGCGGGTCCACGAG	0.617000													8	8					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33644589	33644589	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33644589G>A	ENST00000399362.4	-	18	2132	c.1779C>T	c.(1777-1779)tcC>tcT	p.S593S	CLASP2_ENST00000480013.1_Silent_p.S360S|CLASP2_ENST00000487200.1_Silent_p.S366S|CLASP2_ENST00000359576.5_Silent_p.S593S|CLASP2_ENST00000333778.6_Silent_p.S370S|CLASP2_ENST00000313350.6_Silent_p.S366S|CLASP2_ENST00000539981.1_Silent_p.S345S|CLASP2_ENST00000461133.3_Silent_p.S360S|CLASP2_ENST00000468888.2_Silent_p.S594S|CLASP2_ENST00000307312.7_Silent_p.S82S	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	594										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						TTCCTGGAAGGGAACTGGCTT	0.453000													5	7					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103866850	103866850	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103866850G>A	ENST00000302251.5	-	3	886	c.435C>T	c.(433-435)ttC>ttT	p.F145F	PDGFD_ENST00000393158.2_Silent_p.F151F	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	151	CUB.				positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CATCGGACTTGAATGTGATTT	0.368000													8	121					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754377	49754377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49754377G>A	ENST00000304801.3	-	1	676	c.524C>T	c.(523-525)tCc>tTc	p.S175F		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	175					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TCCCACCATGGAACTATGAGC	0.473000													44	61					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139838948	139838948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139838948C>T	ENST00000303045.6	-	6	1368	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K	COL22A1_ENST00000435777.1_Missense_Mutation_p.E308K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	308	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TACCAGTCTTCCTTCCGAGAG	0.507000										HNSCC(7;0.00092)			28	55					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6266847	6266847	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6266847C>T	ENST00000264870.3	-	4	780	c.515G>A	c.(514-516)cGa>cAa	p.R172Q		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	172					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity	p.R172Q(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TCGACTGGTTCGAAGTACGCC	0.458000													55	110					0	0	1	0	0
DERL1	79139	broad.mit.edu	37	8	124034951	124034951	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124034951T>A	ENST00000259512.4	-	5	726	c.426A>T	c.(424-426)gtA>gtT	p.V142V	RP11-557C18.3_ENST00000521258.1_RNA|DERL1_ENST00000419562.2_Intron|DERL1_ENST00000523036.1_Silent_p.V42V|DERL1_ENST00000519018.1_Silent_p.V42V|DERL1_ENST00000405944.3_Silent_p.V142V	NM_001134671.1|NM_024295.4	NP_001128143.1|NP_077271.1	Q9BUN8	DERL1_HUMAN	derlin 1	142					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|intracellular transport of viral proteins in host cell|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane	MHC class I protein binding|receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	8	Lung NSC(37;1.06e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			ACCAAAATGATACAATCATGT	0.418000											OREG0018957	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	156					0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31473487	31473487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31473487C>T	ENST00000252229.6	+	2	243	c.164C>T	c.(163-165)cCc>cTc	p.P55L	MICB_ENST00000538442.1_Missense_Mutation_p.P23L|MICB_ENST00000399150.3_Missense_Mutation_p.P55L	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	55					antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						GATGGTCAGCCCTTCCTGCGC	0.582000													30	69					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88376921	88376921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:88376921G>A	ENST00000298699.2	-	12	1358	c.1178C>T	c.(1177-1179)cCt>cTt	p.P393L	C12orf50_ENST00000550553.1_Missense_Mutation_p.P354L	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	393										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						TTTTGAAAAAGGAATTCGTTT	0.259000													23	119					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124988220	124988220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124988220C>T	ENST00000522917.1	+	9	972	c.766C>T	c.(766-768)Ccc>Tcc	p.P256S	FER1L6_ENST00000399018.1_Missense_Mutation_p.P256S	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	256	C2 2.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AGAAGGGTTGCCCAAAATGAA	0.498000													47	176					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121341852	121341852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121341852C>T	ENST00000338040.4	+	3	1990	c.1576C>T	c.(1576-1578)Cgt>Tgt	p.R526C		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	526					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		AAACCATTTCCGTCCCCCAGG	0.502000													13	47					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833950	24833950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24833950C>T	ENST00000376451.2	+	15	4561	c.4301C>T	c.(4300-4302)cCc>cTc	p.P1434L	KIAA1217_ENST00000307544.6_Missense_Mutation_p.P901L|KIAA1217_ENST00000458595.1_Missense_Mutation_p.P1157L|KIAA1217_ENST00000396446.1_Missense_Mutation_p.P835L|KIAA1217_ENST00000376462.1_Missense_Mutation_p.P1072L|KIAA1217_ENST00000396445.1_Missense_Mutation_p.P875L|KIAA1217_ENST00000376452.3_Missense_Mutation_p.P1182L|KIAA1217_ENST00000376454.3_Missense_Mutation_p.P1751L			Q5T5P2	SKT_HUMAN	KIAA1217	1751					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						ATGCCTGTCCCCATGAGTGCC	0.577000													59	128					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1119445	1119445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1119445G>A	ENST00000379290.1	+	12	1407	c.1234G>A	c.(1234-1236)Gac>Aac	p.D412N	TTLL10_ENST00000379289.1_Missense_Mutation_p.D412N|TTLL10_ENST00000379288.3_Missense_Mutation_p.D339N			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	412	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCATTCCAGCGACCTCGGCGG	0.597000													58	208					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276773	152276773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152276773C>T	ENST00000368799.1	-	3	10624	c.10589G>A	c.(10588-10590)aGg>aAg	p.R3530K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3530	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGCTTGTCCTGGGCCCCGC	0.577000									Ichthyosis				108	279					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68810291	68810291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68810291G>A	ENST00000508048.1	-	3	230	c.195C>T	c.(193-195)ttC>ttT	p.F65F	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000396188.2_Silent_p.F66F|TMPRSS11A_ENST00000334830.7_Silent_p.F66F			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	66	SEA.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TGCTTTGTCCGAAATTGTTAT	0.333000													34	76					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2049525	2049525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2049525G>A	ENST00000563630.1	-	9	2102	c.1860C>T	c.(1858-1860)ccC>ccT	p.P620P	ZNF598_ENST00000562103.1_Silent_p.P620P|ZNF598_ENST00000431526.1_Silent_p.P675P			Q86UK7	ZN598_HUMAN	zinc finger protein 598	675	Pro-rich.					intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						GGGGTGGGCAGGGGCCGCCGA	0.751000													4	13					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29455196	29455196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29455196C>T	ENST00000389048.3	-	15	3512	c.2606G>A	c.(2605-2607)gGg>gAg	p.G869E	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	869	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GCCGTTTAGCCCTAGAACCGA	0.622000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				30	81					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134049606	134049606	+	Missense_Mutation	SNP	C	C	T	rs140330621		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:134049606C>T	ENST00000359428.5	+	22	3202	c.3058C>T	c.(3058-3060)Cgc>Tgc	p.R1020C	NUP214_ENST00000451030.1_Missense_Mutation_p.R1021C|NUP214_ENST00000411637.2_Missense_Mutation_p.R1010C			P35658	NU214_HUMAN	nucleoporin 214kDa	1020	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CCCCGTGGTTCGCACTCCTTC	0.562000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								44	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179592510	179592510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179592510C>T	ENST00000589042.1	-	68	20019	c.19795G>A	c.(19795-19797)Gga>Aga	p.G6599R	TTN_ENST00000342992.6_Missense_Mutation_p.G5355R|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G6282R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6282	Ig-like 47.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGTGTTCCTTTTAGTATT	0.393000													48	112					0	0	1	0	0
FAM115A	9747	broad.mit.edu	37	7	143573340	143573340	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143573340G>A	ENST00000479870.1	-	2	570	c.362C>T	c.(361-363)tCc>tTc	p.S121F	FAM115A_ENST00000392900.3_Intron|FAM115A_ENST00000355951.2_Missense_Mutation_p.S121F	NM_001206938.1|NM_001206941.1|NM_014719.2	NP_001193867.1|NP_001193870.1|NP_055534.1	Q9Y4C2	F115A_HUMAN	family with sequence similarity 115, member A	121										NS(1)|endometrium(1)|lung(5)	7	Melanoma(164;0.0903)					AACCCCCAGGGAGTCTTTCAC	0.522000													52	135					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179547468	179547468	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179547468T>A	ENST00000589042.1	-	135	33274	c.33050A>T	c.(33049-33051)gAg>gTg	p.E11017V	TTN_ENST00000342992.6_Missense_Mutation_p.E9773V|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10700V|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10700	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTCCCGCTCCTCGTATTC	0.363000													9	200					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32035662	32035662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32035662G>A	ENST00000375244.3	-	18	6521	c.6320C>T	c.(6319-6321)tCc>tTc	p.S2107F	TNXB_ENST00000375247.2_Missense_Mutation_p.S2107F			P22105	TENX_HUMAN	tenascin XB	2179	Fibronectin type-III 13.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CGAGTCAGGGGAGGATCCTGT	0.682000													36	57					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138000129	138000129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:138000129G>A	ENST00000409968.1	+	10	2431	c.2253G>A	c.(2251-2253)agG>agA	p.R751R	THSD7B_ENST00000272643.3_Silent_p.R751R|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Silent_p.R720R					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTGCCCAAGGATGTGCCAAG	0.478000													21	42					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161021355	161021355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161021355C>T	ENST00000368013.3	-	10	1489	c.1169G>A	c.(1168-1170)cGa>cAa	p.R390Q	ARHGAP30_ENST00000368015.1_Missense_Mutation_p.R213Q|ARHGAP30_ENST00000368016.3_Missense_Mutation_p.R390Q	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	390					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CCGCCCAGCTCGTGGTGTGCC	0.602000													38	77					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	14018779	14018779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14018779G>A	ENST00000279593.3	-	2	573	c.364C>T	c.(364-366)Ccc>Tcc	p.P122S		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	122					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCAGGATGGGGGTGAGAGTC	0.547000													60	133					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47390600	47390600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47390600C>T	ENST00000285039.7	-	28	4053	c.3754G>A	c.(3754-3756)Gag>Aag	p.E1252K	MYO5B_ENST00000587895.1_5'UTR|MYO5B_ENST00000324581.6_Missense_Mutation_p.E393K	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1252					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TCGAGCTCCTCGTGGGCCAGC	0.637000													21	81					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197019875	197019875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197019875C>T	ENST00000367412.1	-	10	1733	c.1690G>A	c.(1690-1692)Gag>Aag	p.E564K	F13B_ENST00000490002.1_5'UTR	NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	564	Sushi 9.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						CAATAGGCCTCCCTAGATCCT	0.338000													15	54					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21709108	21709108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21709108C>T	ENST00000388958.3	+	9	753	c.752C>T	c.(751-753)tCa>tTa	p.S251L	OTOA_ENST00000388956.4_Missense_Mutation_p.S172L|OTOA_ENST00000286149.4_Missense_Mutation_p.S251L	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	251					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		GACTCTGCTTCATGGGTCAGT	0.353000													28	88					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9374249	9374249	+	Silent	SNP	G	G	A	rs1129249		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9374249G>A	ENST00000378501.2	+	15	1353	c.1338G>A	c.(1336-1338)agG>agA	p.R446R	PLCB4_ENST00000414679.2_Silent_p.R446R|PLCB4_ENST00000378493.1_Silent_p.R446R|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Silent_p.R446R|PLCB4_ENST00000378473.3_Silent_p.R446R|PLCB4_ENST00000334005.3_Silent_p.R446R	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	446	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AACCAGGCAGGGCTTTGCCAT	0.453000											OREG0025771	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	61					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200008813	200008813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200008813C>T	ENST00000367362.3	+	2	338	c.92C>T	c.(91-93)tCc>tTc	p.S31F	NR5A2_ENST00000236914.3_Intron	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	31					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					CGACACGGATCCCCCATCCCC	0.647000													30	113					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27309058	27309058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27309058C>T	ENST00000397497.4	+	18	2143	c.1692C>T	c.(1690-1692)ttC>ttT	p.F564F	PTK2B_ENST00000517339.1_Intron|PTK2B_ENST00000397501.1_Intron|PTK2B_ENST00000346049.5_Intron|PTK2B_ENST00000338238.4_Intron|PTK2B_ENST00000544172.1_Intron|PTK2B_ENST00000420218.2_Intron			Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	0	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CGGGGGGTTTCCTCTTGGCAC	0.597000													7	28					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477849	88477849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:88477849G>A	ENST00000267549.3	+	2	1216	c.658G>A	c.(658-660)Gaa>Aaa	p.E220K	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	220					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						GGAAAACAAGGAAAAGAAGAG	0.428000													16	35					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330004	125330004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125330004G>A	ENST00000304865.2	-	1	834	c.753C>T	c.(751-753)ctC>ctT	p.L251L		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TTCCATAAAAGAGCGTCACCA	0.463000													10	35					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151945426	151945426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151945426G>A	ENST00000355193.2	-	14	2311	c.2093C>T	c.(2092-2094)aCc>aTc	p.T698I	KMT2C_ENST00000262189.6_Missense_Mutation_p.T698I					lysine (K)-specific methyltransferase 2C																		GGACACTAAGGTTTCTAGTGG	0.403000													27	75					0	0	1	0	0
HSD17B13	345275	broad.mit.edu	37	4	88235022	88235022	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88235022G>A	ENST00000328546.4	-	5	712	c.648C>T	c.(646-648)ctC>ctT	p.L216L	HSD17B13_ENST00000302219.6_Silent_p.L180L	NM_178135.3	NP_835236.2	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	216						extracellular region	binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		AAACTGGGCAGAGACATGAGG	0.408000													26	48					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56320980	56320980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56320980G>A	ENST00000443188.1	-	5	1706	c.996C>T	c.(994-996)ctC>ctT	p.L332L	NLRP11_ENST00000589824.2_Silent_p.L332L|NLRP11_ENST00000592953.1_Silent_p.L233L|NLRP11_ENST00000589093.1_Silent_p.L332L|NLRP11_ENST00000360133.3_Silent_p.L332L	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	332	NACHT.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ACAGACCCACGAGTATTTCAT	0.527000													9	55					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983591	97983591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97983591G>A	ENST00000383696.2	+	1	504	c.463G>A	c.(463-465)Gaa>Aaa	p.E155K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TATGACCAATGAACTATGCAT	0.363000													44	103					0	0	1	0	0
KCNJ11	3767	broad.mit.edu	37	11	17408585	17408585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17408585C>T	ENST00000339994.4	-	1	1621	c.1054G>A	c.(1054-1056)Gac>Aac	p.D352N	KCNJ11_ENST00000528731.1_Missense_Mutation_p.D265N	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	265						integral to membrane	ATP-activated inward rectifier potassium channel activity			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		AGGCTGTGGTCCTCATCAAGC	0.622000											OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	75					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101276378	101276378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101276378G>A	ENST00000519449.1	-	8	1668	c.1352C>T	c.(1351-1353)cCa>cTa	p.P451L	RNF19A_ENST00000341084.2_Missense_Mutation_p.P451L|RNF19A_ENST00000523255.1_Intron	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	451					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			AAGAGAAATTGGAACTACGCC	0.363000													29	31					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240256738	240256738	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240256738C>T	ENST00000319653.9	+	1	1559	c.1329C>T	c.(1327-1329)atC>atT	p.I443I		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	443					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCCCAGGATCAAGAGGCGGC	0.682000													17	95					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31424183	31424183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31424183C>T	ENST00000389202.2	+	15	1781	c.1732C>T	c.(1732-1734)Ccc>Tcc	p.P578S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	578					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCAGCTCTCCCCCAGGCTGCA	0.597000													46	83					0	0	1	0	0
FLT3	2322	broad.mit.edu	37	13	28610179	28610179	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28610179C>T	ENST00000380982.4	-	11	1392	c.1309_splice	c.e11-1	p.R437_splice	FLT3_ENST00000537084.1_Splice_Site_p.R437_splice|FLT3_ENST00000241453.7_Splice_Site_p.R437_splice			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	437					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTTGAGGTTTCCCTATAGAAA	0.473000			"""Mis, O"""		"""AML, ALL"""								46	97					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21306910	21306910	+	Missense_Mutation	SNP	G	G	A	rs147841357	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21306910G>A	ENST00000602326.1	-	8	846	c.263C>T	c.(262-264)cCc>cTc	p.P88L	EIF4G3_ENST00000374937.3_Missense_Mutation_p.P88L|EIF4G3_ENST00000356916.3_Missense_Mutation_p.P92L|EIF4G3_ENST00000264211.8_Missense_Mutation_p.P81L|EIF4G3_ENST00000374935.3_Missense_Mutation_p.P81L|EIF4G3_ENST00000374927.4_Missense_Mutation_p.P81L|EIF4G3_ENST00000400422.1_Missense_Mutation_p.P81L	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	81					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TTGTTGGGGGGGCCCAACATA	0.433000													9	28					0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191300967	191300967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:191300967C>T	ENST00000392328.1	+	3	536	c.212C>T	c.(211-213)tCc>tTc	p.S71F	MFSD6_ENST00000281416.7_Missense_Mutation_p.S71F	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	71					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						CTTCTAATTTCCAAGGTCTTT	0.398000													39	98					0	0	1	0	0
FTMT	94033	broad.mit.edu	37	5	121188021	121188021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121188021G>A	ENST00000321339.1	+	1	372	c.363G>A	c.(361-363)gaG>gaA	p.E121E		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	121	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		AGTCCCGGGAGGAGACCGAGC	0.572000													18	57					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166961934	166961934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:166961934G>A	ENST00000367872.4	+	4	581	c.337G>A	c.(337-339)Ggc>Agc	p.G113S	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Missense_Mutation_p.G82S	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	113					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						TCTCCTTGGAGGCATTTTTTA	0.353000													21	47					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380736	147380736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:147380736C>T	ENST00000240986.4	+	2	707	c.654C>T	c.(652-654)ttC>ttT	p.F218F	GJA8_ENST00000369235.1_Silent_p.F218F	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	218					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					TGTCCCTATTCCTCAACGTGA	0.592000													23	69					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101608912	101608912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101608912G>A	ENST00000311812.2	-	10	1083	c.933C>T	c.(931-933)atC>atT	p.I311I	SNX31_ENST00000428383.2_Silent_p.I212I|SNX31_ENST00000519521.1_5'UTR	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	311					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TCTGGAAAACGATGTCCTGGG	0.507000													21	79					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176002773	176002773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176002773G>A	ENST00000510636.1	+	11	1167	c.893G>A	c.(892-894)aGg>aAg	p.R298K	CDHR2_ENST00000261944.5_Missense_Mutation_p.R298K|CDHR2_ENST00000506348.1_Missense_Mutation_p.R298K	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	298	Cadherin 3.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GGGGTGATCAGGGTCAACGGC	0.642000													3	3					0	0	1	0	0
KDELC1	79070	broad.mit.edu	37	13	103443710	103443710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:103443710G>A	ENST00000376004.4	-	5	1079	c.743C>T	c.(742-744)tCa>tTa	p.S248L	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	248						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ATGGATGTTTGAATTGGATTT	0.428000													140	261					0	0	1	0	0
ZFP82	284406	broad.mit.edu	37	19	36884731	36884731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36884731C>T	ENST00000392161.3	-	5	753	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	ZFP82_ENST00000392171.1_Missense_Mutation_p.E171K	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TCCTTACATTCATAGGGTTTA	0.413000													10	73					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129185811	129185811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129185811C>T	ENST00000296266.3	+	9	987	c.795C>T	c.(793-795)atC>atT	p.I265I	IFT122_ENST00000347300.2_Intron|IFT122_ENST00000431818.2_Silent_p.I64I|IFT122_ENST00000349441.2_Intron|IFT122_ENST00000440957.2_Intron|IFT122_ENST00000348417.2_Silent_p.I214I|IFT122_ENST00000507564.1_Intron|IFT122_ENST00000504021.1_Intron	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	214					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TTCAGGAAATCCCTTCCACTC	0.483000													28	103					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54797988	54797988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54797988G>A	ENST00000293379.4	-	15	1767	c.1506C>T	c.(1504-1506)ttC>ttT	p.F502F	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	502					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						ACATGGCGGGGAAGATGGTGA	0.597000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	85					0	0	1	0	0
SCGB2B2	284402	broad.mit.edu	37	19	35085210	35085210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35085210G>A	ENST00000601241.1	-	3	2216	c.116C>T	c.(115-117)tCc>tTc	p.S39F	SCGB2B2_ENST00000379204.2_Missense_Mutation_p.S39F|SCGB2B2_ENST00000595326.1_Intron			Q4G0G5	SCGBL_HUMAN	secretoglobin, family 2B, member 2	39						extracellular region	binding										GAGGTCTTGGGACACATCAAA	0.507000													23	104					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401587	77401587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77401587G>A	ENST00000282849.5	-	4	947	c.529C>T	c.(529-531)Ctc>Ttc	p.L177F	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	177					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GGCGAGATGAGGAATTCATTT	0.468000													22	80					0	0	1	0	0
RAD23B	5887	broad.mit.edu	37	9	110081045	110081045	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:110081045C>A	ENST00000358015.3	+	6	917	c.566C>A	c.(565-567)tCt>tAt	p.S189Y	RAD23B_ENST00000416373.2_Missense_Mutation_p.S117Y	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	189	UBA 1.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						ACGGGTCAGTCTTACGAGAAT	0.403000								Direct reversal of damage;Nucleotide excision repair (NER)					56	98					1.64573e-32	1.65739e-32	1	1	0
NCAN	1463	broad.mit.edu	37	19	19349165	19349165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19349165C>T	ENST00000252575.5	+	11	3397	c.3354C>T	c.(3352-3354)cgC>cgT	p.R1118R	NCAN_ENST00000538881.1_Silent_p.R569R	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1118	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			ACTGCCGCCGCCGCTCCGGCC	0.652000													27	86					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80746087	80746087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80746087G>A	ENST00000458043.2	+	44	5257	c.5251G>A	c.(5251-5253)Gac>Aac	p.D1751N	OTOGL_ENST00000547103.1_Missense_Mutation_p.D1739N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTCACCGGAAGACTTTTGTGA	0.338000													10	17					0	0	1	0	0
SPATA31D4	389761	broad.mit.edu	37	9	84549058	84549058	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84549058G>A	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							GGGGATGCAGGGTTGGGGACA	0.488000													5	7					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3229530	3229530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3229530C>T	ENST00000217939.6	-	7	6868	c.6714G>A	c.(6712-6714)gtG>gtA	p.V2238V		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2238	Ig-like C2-type 6.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTTTCATCACCACATCCACTT	0.527000													39	34					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206610599	206610599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206610599G>A	ENST00000360409.3	+	10	2562	c.1771G>A	c.(1771-1773)Ggc>Agc	p.G591S	NRP2_ENST00000540178.1_Missense_Mutation_p.G591S|NRP2_ENST00000357785.5_Missense_Mutation_p.G591S|NRP2_ENST00000412873.2_Missense_Mutation_p.G591S|NRP2_ENST00000272849.3_Missense_Mutation_p.G591S|NRP2_ENST00000540841.1_Missense_Mutation_p.G591S|NRP2_ENST00000357118.4_Missense_Mutation_p.G591S	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	591	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GGAGGTGCTGGGCTGTGACTG	0.612000													15	48					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3084710	3084710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3084710G>A	ENST00000397461.1	+	21	2945	c.2561G>A	c.(2560-2562)cGa>cAa	p.R854Q	CNTN4_ENST00000418658.1_Missense_Mutation_p.R854Q|CNTN4_ENST00000448906.2_Missense_Mutation_p.R526Q|CNTN4_ENST00000358480.3_Missense_Mutation_p.R635Q|CNTN4_ENST00000397459.2_Missense_Mutation_p.R526Q|CNTN4_ENST00000427331.1_Missense_Mutation_p.R854Q|CNTN4-AS1_ENST00000442749.2_RNA	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	854	Fibronectin type-III 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGAAAAATACGAACAGTTGGA	0.383000													11	39					0	0	1	0	0
EDN1	1906	broad.mit.edu	37	6	12294197	12294197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:12294197G>A	ENST00000379375.5	+	3	524	c.257G>A	c.(256-258)gGa>gAa	p.G86E		NM_001168319.1|NM_001955.4	NP_001161791.1|NP_001946.3	P05305	EDN1_HUMAN	endothelin 1	86					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	13	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				TATGGACTTGGAAGCCCTAGG	0.408000													14	55					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74684153	74684153	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74684153G>A	ENST00000334011.5	+	7	1336	c.1118G>A	c.(1117-1119)cGa>cAa	p.R373Q		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	373	ZP.					nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					CCCAACCTTCGAAACTCCCCA	0.512000													22	59					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37325573	37325573	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:37325573T>G	ENST00000373091.3	-	6	848	c.832A>C	c.(832-834)Aac>Cac	p.N278H	GRIK3_ENST00000373093.4_Missense_Mutation_p.N278H	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	278					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCTGTCAGGTTCACGCCTGAG	0.567000													23	70					0	0	1	0	0
PKD2L2	27039	broad.mit.edu	37	5	137230282	137230282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137230282C>T	ENST00000508638.1	+	4	563	c.508C>T	c.(508-510)Ctt>Ttt	p.L170F	PKD2L2_ENST00000290431.5_Missense_Mutation_p.L170F|PKD2L2_ENST00000508883.1_Missense_Mutation_p.L170F|PKD2L2_ENST00000350250.4_Missense_Mutation_p.L136F|PKD2L2_ENST00000502810.1_Missense_Mutation_p.L170F	NM_001258449.1	NP_001245378.1	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	170						integral to membrane	calcium ion binding|ion channel activity			breast(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	28			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TAATTTTGGCCTTCAAATTAA	0.333000													15	33					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52660491	52660491	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52660491C>T	ENST00000355568.4	-	16	1540	c.1401G>A	c.(1399-1401)tgG>tgA	p.W467*		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	467							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CTAACTGCTTCCAATATTCCT	0.363000													23	96					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321967	52321967	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:52321967C>T	ENST00000356297.4	-	17	2317	c.2217G>A	c.(2215-2217)caG>caA	p.Q739Q	PXDNL_ENST00000543296.1_Silent_p.Q739Q	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	739					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCCACGTGGGCTGCTGCAGGT	0.697000													5	28					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184233578	184233578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:184233578C>T	ENST00000403733.3	+	22	3668	c.3469C>T	c.(3469-3471)Cgg>Tgg	p.R1157W	WWC2_ENST00000504005.1_Missense_Mutation_p.R839W|WWC2_ENST00000448232.2_Missense_Mutation_p.R1181W|WWC2_ENST00000508747.1_Missense_Mutation_p.R285W|WWC2_ENST00000513834.1_Missense_Mutation_p.R1108W	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1157										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		GTGTCGGCTCCGGGAGCAGAG	0.542000													24	100					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24808358	24808358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24808358G>A	ENST00000216274.5	-	3	552	c.334C>T	c.(334-336)Cgg>Tgg	p.R112W		NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	112	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		GGCCAGGGCCGAGGGCACTGG	0.602000													29	59					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34962328	34962328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34962328G>A	ENST00000329357.5	+	1	1416	c.1380G>A	c.(1378-1380)tcG>tcA	p.S460S		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	460										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GACACACATCGAGAAAACTCC	0.468000													14	76					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13692161	13692161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13692161G>A	ENST00000265104.4	-	79	13911	c.13807C>T	c.(13807-13809)Ctc>Ttc	p.L4603F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4603					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCTGTCCTGAGATCCACAGCG	0.502000									Kartagener syndrome				32	75					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275978	152275978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152275978C>T	ENST00000368799.1	-	3	11419	c.11384G>A	c.(11383-11385)gGa>gAa	p.G3795E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3795	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCAGACCTTCCCTGGGATGT	0.577000									Ichthyosis				195	490					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73566202	73566202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73566202C>T	ENST00000392550.3	+	15	1857	c.1740C>T	c.(1738-1740)ttC>ttT	p.F580F	LLGL2_ENST00000577200.1_Silent_p.F580F|LLGL2_ENST00000167462.5_Silent_p.F580F	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	580					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			TTCAGCCCTTCGTGTTGGTGC	0.677000													5	13					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94700010	94700010	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94700010C>T	ENST00000304338.3	+	6	691	c.537C>T	c.(535-537)tcC>tcT	p.S179S		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	179						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						CACTTGTTTCCAAGGCACAAC	0.328000													33	108					0	0	1	0	0
FER	2241	broad.mit.edu	37	5	108523217	108523217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:108523217C>T	ENST00000281092.4	+	20	2794	c.2410C>T	c.(2410-2412)Cgc>Tgc	p.R804C	FER_ENST00000438717.2_Missense_Mutation_p.R629C	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	804	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		ACCTGAAAATCGCCCTAAGTT	0.453000													24	64					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116599799	116599799	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:116599799G>T	ENST00000410059.1	+	26	2749	c.2269G>T	c.(2269-2271)Gaa>Taa	p.E757*	DPP10_ENST00000409163.1_Nonsense_Mutation_p.E707*|DPP10_ENST00000393147.2_Nonsense_Mutation_p.E761*|DPP10_ENST00000310323.8_Nonsense_Mutation_p.E750*	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	757					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						CTACCCAGATGAAGGTCATAA	0.383000													11	48					1.08611e-07	1.08932e-07	1	1	0
DYSF	8291	broad.mit.edu	37	2	71901373	71901373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71901373G>A	ENST00000258104.3	+	51	5991	c.5714G>A	c.(5713-5715)cGa>cAa	p.R1905Q	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Missense_Mutation_p.R1906Q|DYSF_ENST00000409744.1_Missense_Mutation_p.R1913Q|DYSF_ENST00000410020.3_Missense_Mutation_p.R1944Q|DYSF_ENST00000413539.2_Missense_Mutation_p.R1936Q|DYSF_ENST00000429174.2_Missense_Mutation_p.R1926Q|DYSF_ENST00000409366.1_Missense_Mutation_p.R1927Q|DYSF_ENST00000409582.3_Missense_Mutation_p.R1943Q|DYSF_ENST00000409762.1_Missense_Mutation_p.R1922Q|DYSF_ENST00000409651.1_Missense_Mutation_p.R1937Q|DYSF_ENST00000410041.1_Missense_Mutation_p.R1923Q	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1905						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATCCCAGCACGAGTGGTGTTC	0.517000													27	56					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185165676	185165676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185165676C>T	ENST00000265026.3	+	5	1285	c.951C>T	c.(949-951)gtC>gtT	p.V317V	MAP3K13_ENST00000446828.1_Silent_p.V110V|MAP3K13_ENST00000443863.1_Silent_p.V173V|MAP3K13_ENST00000535426.1_Silent_p.V173V|MAP3K13_ENST00000424227.1_Silent_p.V317V	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	317	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			CTGGCACGGTCGCATGGATGG	0.448000													6	43					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139657436	139657436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139657436C>T	ENST00000263552.6	+	12	1233	c.695C>T	c.(694-696)tCa>tTa	p.S232L	TBXAS1_ENST00000425687.1_Missense_Mutation_p.S164L|TBXAS1_ENST00000416849.2_Missense_Mutation_p.S278L|TBXAS1_ENST00000411653.1_Missense_Mutation_p.S231L|TBXAS1_ENST00000414508.2_Missense_Mutation_p.S232L|TBXAS1_ENST00000458722.1_Missense_Mutation_p.S277L|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000336425.5_Missense_Mutation_p.S231L|TBXAS1_ENST00000436047.2_Missense_Mutation_p.S232L|TBXAS1_ENST00000448866.1_Missense_Mutation_p.S231L	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	231					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					TTTCAAGTATCATTTCCATCC	0.453000													19	65					0	0	1	0	0
SLC38A9	153129	broad.mit.edu	37	5	54922345	54922345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54922345G>A	ENST00000396865.2	-	16	2254	c.1663C>T	c.(1663-1665)Ctg>Ttg	p.L555L	SLC38A9_ENST00000416547.2_Silent_p.L431L|SLC38A9_ENST00000318672.3_Silent_p.L555L|SLC38A9_ENST00000512595.1_Silent_p.L492L|SLC38A9_ENST00000539768.1_3'UTR|SLC38A9_ENST00000515629.1_Silent_p.L492L	NM_173514.3	NP_775785.2	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	555					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				TGAACAATCAGGTTAGCCACG	0.368000													42	110					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6752834	6752834	+	Silent	SNP	G	G	A	rs148058585		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6752834G>A	ENST00000229243.2	-	6	1041	c.948C>T	c.(946-948)ctC>ctT	p.L316L	ACRBP_ENST00000414226.2_Silent_p.L283L|ACRBP_ENST00000542357.1_5'UTR	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	316				L -> F (in Ref. 1; BAB39388).		acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						GCAGCTGCAGGAGGCTGCAAG	0.587000													23	79					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49411641	49411641	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49411641G>A	ENST00000299191.3	+	2	267		c.e2-1			NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						TGTCTTTTCAGAAGCAAAAGC	0.562000													6	11					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129127538	129127538	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129127538T>C	ENST00000505956.1	-	6	1361	c.1199A>G	c.(1198-1200)aAg>aGg	p.K400R	EFCAB12_ENST00000326085.3_Missense_Mutation_p.K400R	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		CTTACAGAGCTTCCAGCATTG	0.572000													5	10					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147863901	147863901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147863901C>T	ENST00000360693.3	-	7	1256	c.1118G>A	c.(1117-1119)tGg>tAg	p.W373*	HTR4_ENST00000521530.1_Intron|HTR4_ENST00000520514.1_Intron|HTR4_ENST00000362016.2_Intron|HTR4_ENST00000521735.1_Intron|HTR4_ENST00000354217.2_Intron|HTR4_ENST00000314512.6_Intron|HTR4_ENST00000517929.1_Intron|HTR4_ENST00000377888.3_Intron	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	359					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AGGCTTTGTCCAATACCTTGC	0.388000													21	35					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21552454	21552454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:21552454G>A	ENST00000281523.2	-	4	856	c.338C>T	c.(337-339)gCc>gTc	p.A113V	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	113						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						ATTTTTCATGGCTTCCAGTGC	0.463000													29	76					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108297011	108297011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:108297011C>T	ENST00000520734.1	-	6	789	c.504G>A	c.(502-504)caG>caA	p.Q168Q	ANGPT1_ENST00000518386.1_Intron|ANGPT1_ENST00000520052.1_Silent_p.Q167Q			Q15389	ANGP1_HUMAN	angiopoietin 1	368					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGTACTGCCTCTGACTGGTAA	0.403000													16	53					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573709	38573709	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38573709C>T	ENST00000222345.6	+	3	2013	c.1504C>T	c.(1504-1506)Cgc>Tgc	p.R502C		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	502					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCTGGGCGCCCGCTACTACCA	0.627000													19	38					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6999962	6999962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6999962C>T	ENST00000389658.3	-	31	4510	c.4417G>A	c.(4417-4419)Gat>Aat	p.D1473N		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1473	Laminin EGF-like 16.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAACGGAAATCGTGGTCCCCT	0.423000													19	41					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347522	140347522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140347522G>A	ENST00000289269.5	+	1	1703	c.1171G>A	c.(1171-1173)Gac>Aac	p.D391N	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		391	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGTCAATGACCAAGACTC	0.552000													30	69					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16962339	16962339	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16962339C>T	ENST00000379803.1	+	6	857	c.843C>T	c.(841-843)ccC>ccT	p.P281P	SIN3B_ENST00000596802.1_Silent_p.P281P|SIN3B_ENST00000248054.5_Silent_p.P281P	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	281					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						TGTCTGCACCCGCCAAGGTAC	0.672000													13	72					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67220115	67220115	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67220115G>A	ENST00000312457.2	-	1	85	c.81C>T	c.(79-81)ccC>ccT	p.P27P	CABP4_ENST00000438189.2_5'UTR|CABP4_ENST00000542025.2_3'UTR	NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	27						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P27P(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AGCCACCTTGGGGGTAGGAGT	0.652000													4	36					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917687	48917687	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48917687C>T	ENST00000311378.4	+	2	1566	c.1038C>T	c.(1036-1038)ttC>ttT	p.F346F	RP11-506D12.5_ENST00000572491.2_RNA|WFIKKN2_ENST00000426127.1_Silent_p.F253F	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	346	BPTI/Kunitz inhibitor 1.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GCTGGCACTTCGATGCCCAGG	0.622000													25	65					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488383	1488383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1488383G>A	ENST00000345913.4	+	9	1445	c.1354G>A	c.(1354-1356)Gat>Aat	p.D452N	TPO_ENST00000382198.1_Missense_Mutation_p.D279N|TPO_ENST00000349624.3_Missense_Mutation_p.D279N|TPO_ENST00000329066.4_Missense_Mutation_p.D452N|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000382201.3_Missense_Mutation_p.D452N|TPO_ENST00000337415.3_Missense_Mutation_p.D452N|TPO_ENST00000346956.3_Missense_Mutation_p.D452N	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	452					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CACCCTGAGGGATTACATCCC	0.577000													13	24					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46946496	46946496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46946496G>A	ENST00000429979.1	-	3	719	c.115C>T	c.(115-117)Cct>Tct	p.P39S	KIAA0226L_ENST00000409879.2_Intron|KIAA0226L_ENST00000480935.1_Intron|KIAA0226L_ENST00000534925.1_Intron|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.P39S|KIAA0226L_ENST00000378784.4_Intron|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.P39S|KIAA0226L_ENST00000322896.6_Intron|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.P39S|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.P39S	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	39										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						AATTGGCAAGGAGGATGGTCA	0.542000													8	30					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241964441	241964441	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:241964441G>A	ENST00000366552.2	+	27	3377	c.3170G>A	c.(3169-3171)cGa>cAa	p.R1057Q	WDR64_ENST00000437684.2_Missense_Mutation_p.R890Q	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	1057										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CAGGCACCACGAAGAAGAAGT	0.373000													25	74					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124201687	124201687	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124201687C>T	ENST00000360013.3	+	28	4345	c.4218C>T	c.(4216-4218)tcC>tcT	p.S1406S	KALRN_ENST00000240874.3_Silent_p.S1406S|KALRN_ENST00000460856.1_Silent_p.S1397S	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1406	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGGCCAACTCCATCTCTTCCT	0.512000													16	129					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44637951	44637951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:44637951G>A	ENST00000332990.5	-	3	356	c.340C>T	c.(340-342)Cct>Tct	p.P114S		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	114						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						TCTAGCAAAGGAGGCTCTTCA	0.388000													4	39					0	0	1	0	0
YAE1D1	57002	broad.mit.edu	37	7	39610212	39610212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:39610212C>T	ENST00000432096.2	+	2	250	c.237C>T	c.(235-237)ctC>ctT	p.L79L	YAE1D1_ENST00000448268.1_Silent_p.L79L|YAE1D1_ENST00000223273.2_Silent_p.L79L			Q9NRH1	CG036_HUMAN	Yae1 domain containing 1	79																	ATGGACGACTCCGAGGAACAT	0.348000													26	89					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20552473	20552473	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20552473C>T	ENST00000504154.1	+	25	2765	c.2513C>T	c.(2512-2514)tCt>tTt	p.S838F	SLIT2_ENST00000509394.2_3'UTR|SLIT2_ENST00000273739.5_Missense_Mutation_p.S842F|SLIT2_ENST00000503823.1_Missense_Mutation_p.S830F|SLIT2_ENST00000503837.1_Missense_Mutation_p.S834F	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	838					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AATGACATTTCTGTTGTGCCT	0.343000													21	67					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106554835	106554835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:106554835G>A	ENST00000369096.4	+	7	2186	c.1952G>A	c.(1951-1953)cGa>cAa	p.R651Q	PRDM1_ENST00000369091.2_Missense_Mutation_p.R615Q|PRDM1_ENST00000369089.3_Missense_Mutation_p.R517Q	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	651					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACCCACCTGCGACTCCATTCT	0.547000			"""D, N, Mis, F, S"""		DLBCL								40	55					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171911	68171911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:68171911C>T	ENST00000243457.3	+	2	1114	c.731C>T	c.(730-732)cCt>cTt	p.P244L	KCNJ2_ENST00000535240.1_Missense_Mutation_p.P244L	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	244					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					GAGTATATCCCTCTGGATCAA	0.443000													24	70					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66083207	66083207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66083207G>A	ENST00000311330.3	-	1	1308	c.1292C>T	c.(1291-1293)cCc>cTc	p.P431L	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	431	Pro-rich.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	ACTGAGCGGGGGTGGCCAGGT	0.657000													58	93					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23731354	23731354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23731354G>A	ENST00000304749.2	-	1	220	c.150C>T	c.(148-150)ttC>ttT	p.F50F	CST1_ENST00000398402.1_Silent_p.F50F	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	50						extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					CGCTGATGGCGAAGTGAAGGG	0.572000													11	76					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3265441	3265441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3265441C>T	ENST00000520002.1	-	15	2609	c.2054G>A	c.(2053-2055)gGg>gAg	p.G685E	CSMD1_ENST00000542608.1_Missense_Mutation_p.G684E|CSMD1_ENST00000539096.1_Missense_Mutation_p.G684E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G684E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G685E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G685E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G685E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	685	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GATGTTGAACCCTCTGCCAGT	0.448000													5	11					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22676877	22676877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:22676877G>A	ENST00000376603.2	+	6	1174	c.1032G>A	c.(1030-1032)aaG>aaA	p.K344K	SPAG6_ENST00000376601.1_Intron|SPAG6_ENST00000538630.1_Silent_p.K243K|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376624.3_Silent_p.K268K|SPAG6_ENST00000313311.6_Silent_p.K268K			O75602	SPAG6_HUMAN	sperm associated antigen 6	268					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						AATACGTGAAGAAAAATGCTT	0.358000													19	40					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701182	143701182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143701182C>T	ENST00000408922.2	+	1	161	c.93C>T	c.(91-93)ttC>ttT	p.F31F		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TTCTGATATTCCTTGTGGCCT	0.488000													8	49					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139158244	139158244	+	Silent	SNP	G	G	A	rs148245905		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139158244G>A	ENST00000395297.1	-	15	3668	c.3498C>T	c.(3496-3498)ctC>ctT	p.L1166L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1166								p.L1166L(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTCCTCCAGGGAGCCCCAGTT	0.438000										HNSCC(54;0.14)			33	76					0	0	1	0	0
FAM47E-STBD1	100631383	broad.mit.edu	37	4	77227995	77227995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77227995G>A	ENST00000237642.6	+	1	817	c.73G>A	c.(73-75)Ggc>Agc	p.G25S	FAM47E-STBD1_ENST00000539752.1_Intron|FAM47E_ENST00000515604.1_Intron	NM_003943.4	NP_003934.1																					GCTGCTGCGGGGCGGCCCTGG	0.697000											OREG0016232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	45					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886858	123886858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123886858G>A	ENST00000320891.4	+	1	577	c.577G>A	c.(577-579)Gcc>Acc	p.A193T		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A193T(1)		NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AGACACCTCAGCCAACGTGAT	0.527000													93	147					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104061975	104061975	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104061975G>A	ENST00000265148.3	-	36	5839	c.5750C>T	c.(5749-5751)gCt>gTt	p.A1917V	CENPE_ENST00000380026.3_Missense_Mutation_p.A1892V	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1917					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		ACTCACTCTAGCTTTGGTTTC	0.393000													24	40					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63064844	63064844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63064844C>T	ENST00000544661.1	+	4	539	c.111C>T	c.(109-111)ttC>ttT	p.F37F	SLC22A10_ENST00000332793.6_Silent_p.F192F|SLC22A10_ENST00000526800.1_Intron|SLC22A10_ENST00000525620.1_3'UTR|SLC22A10_ENST00000535888.1_5'UTR			Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	192						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GCGCTGCCTTCGCTCCCACCT	0.428000													33	136					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84733647	84733647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:84733647G>A	ENST00000372142.2	+	8	999	c.725G>A	c.(724-726)gGa>gAa	p.G242E	NRG3_ENST00000545131.1_Missense_Mutation_p.G113E|NRG3_ENST00000372141.2_Missense_Mutation_p.G463E|NRG3_ENST00000404547.1_Missense_Mutation_p.G463E|NRG3_ENST00000537893.1_Missense_Mutation_p.G113E|NRG3_ENST00000556918.1_Missense_Mutation_p.G293E|NRG3_ENST00000404576.2_Missense_Mutation_p.G267E	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	463	Ser/Thr-rich.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		CCTGACAGAGGAAGCCAGTCT	0.527000													5	59					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46976939	46976939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46976939G>A	ENST00000371253.2	-	11	2447	c.2232C>T	c.(2230-2232)ctC>ctT	p.L744L	GPR110_ENST00000283297.5_Silent_p.L547L|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	744					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CAAAAGCCAGGAGTGGTTTGC	0.473000													20	68					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30365431	30365431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30365431C>T	ENST00000340513.4	+	9	1400	c.872C>T	c.(871-873)cCt>cTt	p.P291L	TPX2_ENST00000300403.6_Missense_Mutation_p.P291L			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	291					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			CGAAAGCATCCTTCATCTCCT	0.363000													36	67					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6175052	6175052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6175052G>A	ENST00000264870.3	-	12	1773	c.1508C>T	c.(1507-1509)gCt>gTt	p.A503V		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	503					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GGGCTTTTTAGCTCCGTACAT	0.463000													16	54					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24239784	24239784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:24239784C>T	ENST00000338315.4	+	4	417	c.417C>T	c.(415-417)agC>agT	p.S139S	MFSD2B_ENST00000406420.3_Silent_p.S139S			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	139					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						CCTTCACCAGCCTGCGAGGCC	0.662000													6	81					0	0	1	0	0
SERPINI1	5274	broad.mit.edu	37	3	167525098	167525098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167525098C>T	ENST00000295777.5	+	6	1379	c.948C>T	c.(946-948)ttC>ttT	p.F316F	SERPINI1_ENST00000488374.1_3'UTR|SERPINI1_ENST00000446050.2_Silent_p.F316F	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	316					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						CTGAAATTTTCATCAAAGATG	0.294000													15	100					0	0	1	0	0
DNALI1	7802	broad.mit.edu	37	1	38027255	38027255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38027255G>A	ENST00000296218.7	+	4	571	c.561G>A	c.(559-561)caG>caA	p.Q187Q	DNALI1_ENST00000497858.1_3'UTR|DNALI1_ENST00000541606.1_Silent_p.Q39Q	NM_003462.3	NP_003453.2	O14645	IDLC_HUMAN	dynein, axonemal, light intermediate chain 1	165					cellular component movement|single fertilization	axonemal dynein complex	microtubule motor activity			breast(1)|kidney(1)|large_intestine(2)|ovary(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTGCCTACCAGACCCTGTACG	0.597000											OREG0013380	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	33					0	0	1	0	0
CMBL	134147	broad.mit.edu	37	5	10290816	10290816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:10290816C>T	ENST00000296658.3	-	2	479	c.59G>A	c.(58-60)gGg>gAg	p.G20E	CMBL_ENST00000510532.1_5'UTR	NM_138809.3	NP_620164.1	Q96DG6	CMBL_HUMAN	carboxymethylenebutenolidase homolog (Pseudomonas)	20						cytosol	hydrolase activity|protein binding			endometrium(1)|large_intestine(1)|lung(9)|skin(1)|stomach(1)	13						ACGGCCTAGCCCTCCATACTC	0.473000													10	151					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53997401	53997401	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:53997401G>A	ENST00000396328.1	-	11	1371	c.1132C>T	c.(1132-1134)Caa>Taa	p.Q378*	WDR72_ENST00000559418.1_Nonsense_Mutation_p.Q388*|WDR72_ENST00000360509.5_Nonsense_Mutation_p.Q378*|WDR72_ENST00000557913.1_Nonsense_Mutation_p.Q375*	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	378										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		AAATTATCTTGAAGAGTCCAG	0.353000													23	72					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468244	56468244	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56468244G>A	ENST00000312153.1	+	1	381	c.381G>A	c.(379-381)aaG>aaA	p.K127K		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						CCATCTCCAAGCCCCTGCTTT	0.522000													33	169					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16870169	16870169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16870169C>T	ENST00000524140.2	+	7	2321	c.1903C>T	c.(1903-1905)Cgt>Tgt	p.R635C	NWD1_ENST00000523826.1_Missense_Mutation_p.R429C|NWD1_ENST00000379808.3_Missense_Mutation_p.R635C|NWD1_ENST00000339803.6_Missense_Mutation_p.R500C|NWD1_ENST00000552788.1_Missense_Mutation_p.R635C|NWD1_ENST00000549814.1_Missense_Mutation_p.R635C	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	635	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGTGCGGCTTCGTCGGGATCT	0.652000													8	15					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201079390	201079390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201079390C>T	ENST00000362061.3	-	2	386	c.160G>A	c.(160-162)Gag>Aag	p.E54K	CACNA1S_ENST00000367338.3_Missense_Mutation_p.E54K	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	54					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATGATCGTCTCGAAGGGCCTG	0.577000													23	53					0	0	1	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113588364	113588364	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113588364C>T	ENST00000358160.4	+	3	677	c.185C>T	c.(184-186)tCc>tTc	p.S62F	GRAMD1C_ENST00000452134.2_5'UTR|GRAMD1C_ENST00000479212.1_3'UTR	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	62						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						ATTTCAAGTTCCACCTATAAA	0.303000													34	88					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153219	5153219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5153219G>A	ENST00000307388.1	-	1	653	c.654C>T	c.(652-654)acC>acT	p.T218T		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CATAGGACAAGGTTATAAATA	0.423000													36	70					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132623221	132623221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:132623221C>T	ENST00000315480.4	+	7	494	c.336C>T	c.(334-336)tcC>tcT	p.S112S	USP20_ENST00000358355.1_Silent_p.S112S|USP20_ENST00000372429.3_Silent_p.S112S			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	112					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				CACAGGACTCCCCGCCACCCT	0.567000													70	136					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34778553	34778553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34778553C>T	ENST00000338074.2	+	11	1295	c.1134C>T	c.(1132-1134)tcC>tcT	p.S378S	EPB41L1_ENST00000202028.5_Silent_p.S316S|EPB41L1_ENST00000373941.1_Silent_p.S378S|EPB41L1_ENST00000441639.1_Silent_p.S316S|EPB41L1_ENST00000373946.3_Silent_p.S347S|EPB41L1_ENST00000373950.2_Silent_p.S281S	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	378	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					GGCTGGTGTCCCCTGAGCCCC	0.632000													18	44					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073116	17073116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17073116C>T	ENST00000359963.3	-	1	584	c.325G>A	c.(325-327)Gtt>Att	p.V109I		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	109					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GTCAGCAGAACCACGAAGGCT	0.657000													19	64					0	0	1	0	0
FES	2242	broad.mit.edu	37	15	91433170	91433170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91433170G>A	ENST00000328850.3	+	8	1169	c.1027G>A	c.(1027-1029)Gag>Aag	p.E343K	FES_ENST00000394300.3_Missense_Mutation_p.E285K|FES_ENST00000394302.1_Missense_Mutation_p.E285K|FES_ENST00000450438.2_Missense_Mutation_p.E285K|FES_ENST00000448367.1_3'UTR|FES_ENST00000414248.2_Missense_Mutation_p.E285K|FES_ENST00000444422.2_Missense_Mutation_p.E343K	NM_002005.3	NP_001996.1	P07332	FES_HUMAN	feline sarcoma oncogene	343					axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GAATGAAGAGGAGAACACCCA	0.647000													25	98					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32975413	32975413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32975413C>T	ENST00000340811.4	-	8	1935	c.1827G>A	c.(1825-1827)agG>agA	p.R609R	PKP2_ENST00000070846.6_Silent_p.R653R	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	653					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTTTTACTTTCCTGCTTCGAC	0.378000													15	68					0	0	1	0	0
SLAMF1	6504	broad.mit.edu	37	1	160607071	160607071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160607071C>T	ENST00000302035.6	-	2	674	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	SLAMF1_ENST00000538290.1_Missense_Mutation_p.E109K|SLAMF1_ENST00000235739.5_Missense_Mutation_p.E109K|SLAMF1_ENST00000355199.3_Missense_Mutation_p.E109K|SLAMF1_ENST00000494463.1_5'UTR	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	109					interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TTCCTGCTTTCCCGTATCCCC	0.468000													36	97					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106124613	106124613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106124613G>A	ENST00000369704.3	+	4	697	c.563G>A	c.(562-564)cGa>cAa	p.R188Q	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	188										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GAAACAGAGCGATCAAAAGAG	0.473000													25	47					0	0	1	0	0
UTP11L	51118	broad.mit.edu	37	1	38484756	38484756	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38484756T>A	ENST00000373014.4	+	5	429	c.368T>A	c.(367-369)cTc>cAc	p.L123H	UTP11L_ENST00000537711.1_Missense_Mutation_p.L123H|UTP11L_ENST00000488453.1_3'UTR	NM_016037.3	NP_057121.2	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)	123					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding			NS(1)|cervix(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AAATCAGAGCTCCATCTGCTG	0.363000													25	82					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19506390	19506390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19506390C>T	ENST00000407835.1	+	19	1916	c.1660C>T	c.(1660-1662)Cgg>Tgg	p.R554W	CDC45_ENST00000437685.2_Missense_Mutation_p.R586W|CDC45_ENST00000263201.1_Missense_Mutation_p.R554W|CDC45_ENST00000404724.3_Missense_Mutation_p.R508W			O75419	CDC45_HUMAN	cell division cycle 45	554					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						AGCTGAGGATCGGAGCAAGTT	0.552000													43	138					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20806929	20806929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20806929C>T	ENST00000359062.3	+	15	3014	c.2974C>T	c.(2974-2976)Cgt>Tgt	p.R992C	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	992	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTTCATGGATCGTTCTGCTCC	0.468000													22	64					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39883676	39883676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39883676C>T	ENST00000341184.6	+	2	539	c.324C>T	c.(322-324)ttC>ttT	p.F108F		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	108					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					CCGAGTATTTCGTGCGCACCA	0.706000													7	21					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42122113	42122113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42122113C>T	ENST00000502486.1	-	5	1924	c.1345G>A	c.(1345-1347)Gaa>Aaa	p.E449K	BEND4_ENST00000504360.1_Intron	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	449	BEN.									NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						GGGCGTCTTTCGGGACCTGTC	0.498000													11	22					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614655	247614655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247614655G>A	ENST00000318749.6	-	1	653	c.630C>T	c.(628-630)ttC>ttT	p.F210F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F210F(1)		endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GCACCAACACGAAGAAGGCCA	0.562000													23	48					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123594435	123594435	+	Missense_Mutation	SNP	C	C	T	rs141109529		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123594435C>T	ENST00000340011.5	+	3	1168	c.811C>T	c.(811-813)Cct>Tct	p.P271S	SPAM1_ENST00000460182.1_Missense_Mutation_p.P271S|SPAM1_ENST00000439500.1_Missense_Mutation_p.P271S|SPAM1_ENST00000223028.7_Missense_Mutation_p.P271S|SPAM1_ENST00000402183.2_Missense_Mutation_p.P271S	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	271					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	TCAGCAGTCTCCTGTAGCTGC	0.413000													40	110					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24187498	24187498	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24187498G>A	ENST00000265769.4	+	11	1083	c.972_splice	c.e11-1	p.D325_splice	ADAM28_ENST00000540823.1_Splice_Site_p.D92_splice|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Splice_Site_p.D325_splice|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000518516.1_3'UTR|ADAM28_ENST00000397649.3_Splice_Site_p.D72_splice|RP11-624C23.1_ENST00000519689.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	325	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		ATACCTTTAGGACCACAGCGA	0.408000													25	100					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353848	77353848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77353848C>T	ENST00000282849.5	-	16	2848	c.2430G>A	c.(2428-2430)ggG>ggA	p.G810G		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	810	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AGGGGAACTCCCCAGGCCAGT	0.577000													26	65					0	0	1	0	0
AUH	549	broad.mit.edu	37	9	94123928	94123928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:94123928G>A	ENST00000375731.4	-	1	267	c.244C>T	c.(244-246)Ctg>Ttg	p.L82L	AUH_ENST00000303617.5_Silent_p.L82L|AUH_ENST00000422391.2_Silent_p.L82L|AUH_ENST00000478465.1_5'UTR	NM_001698.2	NP_001689.1	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-CoA hydratase	82					branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						TCCTCCTCCAGGTGCCGCACC	0.716000													3	12					0	0	1	0	0
RDH16	8608	broad.mit.edu	37	12	57348915	57348915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57348915G>A	ENST00000398138.3	-	2	1203	c.347C>T	c.(346-348)tCc>tTc	p.S116F	RDH16_ENST00000360752.4_Intron	NM_003708.3	NP_003699.3	O75452	RDH16_HUMAN	retinol dehydrogenase 16 (all-trans)	116					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)	16						CGTGGGCAAGGAGATGCCAGC	0.552000													18	24					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994216	140994216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140994216G>A	ENST00000285879.4	+	4	1312	c.1026G>A	c.(1024-1026)atG>atA	p.M342I	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	342				MT -> VS (in Ref. 2; AAC24227).			protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AGATTCCTATGACCTCCTCCT	0.463000										HNSCC(15;0.026)			115	94					0	0	1	0	0
CCL8	6355	broad.mit.edu	37	17	32647341	32647341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:32647341C>T	ENST00000394620.1	+	2	596	c.130C>T	c.(130-132)Cct>Tct	p.P44S		NM_005623.2	NP_005614.2	P80075	CCL8_HUMAN	chemokine (C-C motif) ligand 8	44					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity			NS(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Ovarian(249;0.0443)|Breast(31;0.151)				TAGGAAAATTCCTATCCAGAG	0.443000													9	45					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50605650	50605650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50605650C>T	ENST00000444124.2	-	4	543	c.343G>A	c.(343-345)Gag>Aag	p.E115K	DDC_ENST00000357936.5_Missense_Mutation_p.E115K|DDC_ENST00000380984.4_Missense_Mutation_p.E115K|DDC_ENST00000489162.1_5'UTR|DDC_ENST00000431062.1_Missense_Mutation_p.E115K|AC018705.5_ENST00000454521.1_RNA|DDC_ENST00000426377.1_Intron	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	115	2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ATCACAGTCTCCAGCTCTGTG	0.552000													21	47					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112535	57112535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57112535G>A	ENST00000454682.1	-	3	3060	c.2779C>T	c.(2779-2781)Cct>Tct	p.P927S	NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000548563.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						ATTCCTTTAGGGGCTGGAGTT	0.617000			T	BCL6	NHL								15	31					0	0	1	0	0
CD274	29126	broad.mit.edu	37	9	5457416	5457416	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:5457416C>T	ENST00000381577.3	+	3	476	c.390C>T	c.(388-390)gtC>gtT	p.V130V	CD274_ENST00000498261.1_3'UTR|CD274_ENST00000381573.4_Intron	NM_014143.3	NP_054862.1	Q9NZQ7	PD1L1_HUMAN	CD274 molecule	130					cell proliferation|cell surface receptor linked signaling pathway|immune response|T cell costimulation	endomembrane system|integral to membrane	receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000742)|Lung(218;0.111)		CTGTGAAAGTCAATGGTAAGA	0.393000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								4	31					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6599215	6599215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6599215C>T	ENST00000433363.2	-	7	1118	c.885G>A	c.(883-885)gaG>gaA	p.E295E	SLC13A5_ENST00000381074.4_Silent_p.E252E|SLC13A5_ENST00000573648.1_Silent_p.E295E|SLC13A5_ENST00000293800.6_Silent_p.E278E	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	295						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						GGGCAGCCTTCTCGTTTTTCT	0.562000													60	94					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28913995	28913995	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28913995C>T	ENST00000257192.4	+	8	1047	c.835C>T	c.(835-837)Caa>Taa	p.Q279*		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	279	Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CATAGAAATTCAAGAAAATAC	0.338000													23	73					0	0	1	0	0
RECQL	5965	broad.mit.edu	37	12	21624011	21624011	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21624011A>G	ENST00000444129.2	-	14	2157	c.1689T>C	c.(1687-1689)gcT>gcC	p.A563A	RECQL_ENST00000421138.2_Silent_p.A563A	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	563					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						TGGTAGCATAAGCTGTAAAAC	0.338000								Other identified genes with known or suspected DNA repair function					32	76					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25451229	25451229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25451229G>A	ENST00000255324.5	+	34	4730	c.4678G>A	c.(4678-4680)Gag>Aag	p.E1560K	RNF17_ENST00000381921.1_Missense_Mutation_p.E1518K|RNF17_ENST00000339524.3_Missense_Mutation_p.E570K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1560					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GGATCTAGGGGAGACAAGAAT	0.463000													43	90					0	0	1	0	0
KLRC4	8302	broad.mit.edu	37	12	10560951	10560951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10560951G>A	ENST00000309384.1	-	3	498	c.317C>T	c.(316-318)tCc>tTc	p.S106F	KLRC4-KLRK1_ENST00000539300.1_Silent_p.F97F	NM_013431.2	NP_038459.1	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C, member 4	106					cellular defense response	integral to membrane	binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	5						TCTATTCAGGGAAAAATTGTT	0.279000													12	29					0	0	1	0	0
ARHGAP44	9912	broad.mit.edu	37	17	12832322	12832322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12832322G>A	ENST00000379672.5	+	7	841	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	ARHGAP44_ENST00000340825.3_Missense_Mutation_p.E181K|ARHGAP44_ENST00000262444.9_Missense_Mutation_p.E181K	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	181	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						TGCCCTCAGGGAAGAAATGGA	0.552000													10	14					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38593037	38593037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38593037G>A	ENST00000413689.1	-	28	5019	c.4826C>T	c.(4825-4827)tCg>tTg	p.S1609L	SCN5A_ENST00000423572.2_Missense_Mutation_p.S1608L|SCN5A_ENST00000425664.1_Missense_Mutation_p.S1591L|SCN5A_ENST00000455624.2_Missense_Mutation_p.S1576L|SCN5A_ENST00000450102.2_Missense_Mutation_p.S1555L|SCN5A_ENST00000449557.2_Missense_Mutation_p.S1555L|SCN5A_ENST00000414099.2_Missense_Mutation_p.S1591L|SCN5A_ENST00000451551.2_Missense_Mutation_p.S1555L|SCN5A_ENST00000333535.4_Missense_Mutation_p.S1609L|SCN5A_ENST00000443581.1_Missense_Mutation_p.S1608L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1609			S -> W (in LQT3).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GATGATGTCCGAGAGCACAGT	0.617000													24	76					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039025	11039025	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039025C>T	ENST00000470054.1	-	0	1178									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACACAACCCTCAATTGTAGGA	0.383000													28	691					0	0	1	0	0
FCHSD1	89848	broad.mit.edu	37	5	141029033	141029033	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141029033G>A	ENST00000435817.2	-	5	354	c.304C>T	c.(304-306)Cag>Tag	p.Q102*	FCHSD1_ENST00000519800.1_Nonsense_Mutation_p.Q100*|FCHSD1_ENST00000522783.1_Nonsense_Mutation_p.Q100*|FCHSD1_ENST00000522126.1_Nonsense_Mutation_p.Q26*	NM_033449.2	NP_258260.1	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	102									FCHSD1/BRAF(2)	central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGACGCCTGGAGTCGGGTT	0.637000													72	119					0	0	1	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249751	119249751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:119249751C>T	ENST00000217999.2	-	1	96	c.22G>A	c.(22-24)Gac>Aac	p.D8N	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	8					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						AACACGGTGTCGTGGACGAGC	0.607000													8	35					0	0	1	0	0
SIDT1	54847	broad.mit.edu	37	3	113304061	113304061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113304061C>T	ENST00000264852.4	+	9	1671	c.945C>T	c.(943-945)ttC>ttT	p.F315F	SIDT1_ENST00000393830.3_Silent_p.F315F	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	315						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						TCAGTGTCTTCATCTTCCTGT	0.413000													63	202					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113075226	113075226	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113075226C>T	ENST00000316851.7	+	2	316	c.316_splice	c.e2+1	p.Q106_splice	NCAM1_ENST00000401611.2_Splice_Site_p.Q115_splice|NCAM1_ENST00000533760.1_5'UTR|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	116	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane		p.Q106*(1)|p.Q115*(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GAAGATCTTTCGTAAGAGCCT	0.517000													8	25					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28539966	28539966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28539966C>T	ENST00000452236.2	-	4	4317	c.3700G>A	c.(3700-3702)Gaa>Aaa	p.E1234K		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1234					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ttcaatccttcgtcggtagcc	0.328000													19	50					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228482721	228482721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228482721C>T	ENST00000570156.2	+	48	12997	c.12923C>T	c.(12922-12924)aCc>aTc	p.T4308I	OBSCN_ENST00000366707.4_Missense_Mutation_p.T998I|OBSCN_ENST00000422127.1_Missense_Mutation_p.T3879I|OBSCN_ENST00000359599.6_Missense_Mutation_p.T2726I|OBSCN_ENST00000284548.11_Missense_Mutation_p.T3879I|OBSCN_ENST00000366709.4_Missense_Mutation_p.T998I	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3351	Ig-like 44.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGGAGAGGACCTCGGCCACA	0.582000													35	89					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39563886	39563886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39563886C>T	ENST00000287152.7	-	7	884	c.790G>A	c.(790-792)Ggc>Agc	p.G264S	KIF6_ENST00000373215.3_Missense_Mutation_p.G264S|KIF6_ENST00000538893.1_Missense_Mutation_p.G264S|KIF6_ENST00000373216.3_Missense_Mutation_p.G264S|KIF6_ENST00000373213.4_Missense_Mutation_p.G103S	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	264	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						AGAAGATGGCCCCCTACTCCA	0.448000													17	77					0	0	1	0	0
GZMA	3001	broad.mit.edu	37	5	54405889	54405889	+	Missense_Mutation	SNP	G	G	A	rs147876051	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54405889G>A	ENST00000274306.6	+	5	703	c.668G>A	c.(667-669)cGa>cAa	p.R223Q		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	223	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GGTGTTTTCCGAGGGGTCACT	0.483000													34	75					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71610209	71610209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71610209C>T	ENST00000355962.4	-	2	243	c.110G>A	c.(109-111)aGa>aAa	p.R37K	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	37					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CCTGGCCTTTCTGCCTTTCAT	0.502000													23	55					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60757792	60757792	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60757792G>A	ENST00000303375.5	+	16	2853	c.2451G>A	c.(2449-2451)cgG>cgA	p.R817R		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	817					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						CGGACGTGCGGGAGCCCGACG	0.652000													46	134					0	0	1	0	0
HUNK	30811	broad.mit.edu	37	21	33318442	33318442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:33318442C>T	ENST00000270112.2	+	4	1065	c.705C>T	c.(703-705)ctC>ctT	p.L235L		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	235	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						CTGAACTGCTCGCCAGGAAGA	0.542000													7	84					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54219328	54219328	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54219328G>A	ENST00000259782.4	+	9	1240	c.1144G>A	c.(1144-1146)Gaa>Aaa	p.E382K		NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	382					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			GCAAGTCCGTGAAGATTTCTT	0.338000													32	93					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116548684	116548684	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:116548684T>G	ENST00000410059.1	+	18	2039	c.1559T>G	c.(1558-1560)aTg>aGg	p.M520R	DPP10_ENST00000409163.1_Missense_Mutation_p.M470R|DPP10_ENST00000393147.2_Missense_Mutation_p.M524R|DPP10_ENST00000310323.8_Missense_Mutation_p.M513R	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	520					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity	p.M513T(1)		breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AGCAATTCTATGCTGAAGGAA	0.328000													14	48					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28541300	28541300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28541300G>A	ENST00000452236.2	-	4	2983	c.2366C>T	c.(2365-2367)tCa>tTa	p.S789L		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	789					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ttttggttgtgaacttatttc	0.338000													16	63					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32913745	32913745	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32913745C>T	ENST00000544455.1	+	11	5480	c.5253C>T	c.(5251-5253)taC>taT	p.Y1751Y	BRCA2_ENST00000380152.3_Silent_p.Y1751Y	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1751					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GCTATTCCTACCATTCTGATG	0.303000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			25	53					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169529932	169529932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169529932G>A	ENST00000367796.3	-	4	647	c.446C>T	c.(445-447)aCc>aTc	p.T149I	F5_ENST00000546081.1_Missense_Mutation_p.T12I|F5_ENST00000367797.3_Missense_Mutation_p.T149I			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	149	F5/8 type A 1.|Plastocyanin-like 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCATTCATAGGTGTATTCTCG	0.507000													33	124					0	0	1	0	0
ZNF558	148156	broad.mit.edu	37	19	8931968	8931968	+	Silent	SNP	G	G	A	rs143685735	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8931968G>A	ENST00000601372.1	-	7	846	c.135C>T	c.(133-135)ttC>ttT	p.F45F	ZNF558_ENST00000301475.1_Silent_p.F45F|ZNF558_ENST00000444186.2_5'UTR			Q96NG5	ZN558_HUMAN	zinc finger protein 558	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						CCACATCCTCGAAGGTTACCA	0.587000													53	97					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160952867	160952867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160952867C>T	ENST00000447678.1	-	40	6137	c.6017G>A	c.(6016-6018)gGa>gAa	p.G2006E	LPA_ENST00000484276.1_Intron|LPA_ENST00000316300.5_Missense_Mutation_p.G2006E	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4514	Kringle 18.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGAAGTGACTCCTTGTAAAAT	0.463000													33	45					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20150048	20150048	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20150048C>T	ENST00000245957.5	+	13	1405	c.1329C>T	c.(1327-1329)ttC>ttT	p.F443F	C20orf26_ENST00000451767.2_Silent_p.F443F|C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377306.1_Silent_p.F443F|C20orf26_ENST00000377309.2_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	443										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TGGTCCCTTTCAACACCTGCA	0.473000													31	92					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152496921	152496921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152496921G>A	ENST00000427231.2	-	61	8835	c.8633C>T	c.(8632-8634)cCc>cTc	p.P2878L	NEB_ENST00000409198.1_Missense_Mutation_p.P2878L|NEB_ENST00000397345.3_Missense_Mutation_p.P2878L|NEB_ENST00000604864.1_Missense_Mutation_p.P2878L|NEB_ENST00000172853.10_Missense_Mutation_p.P2878L|NEB_ENST00000603639.1_Missense_Mutation_p.P2878L	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2878					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCTCTGGTCGGGCAGGCATGT	0.542000													69	221					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141215150	141215150	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141215150C>T	ENST00000389484.3	-	61	10667	c.9696G>A	c.(9694-9696)ggG>ggA	p.G3232G		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3232					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTTGGTTTTCCCATCAGTCC	0.428000										TSP Lung(27;0.18)			57	144					0	0	1	0	0
PRKD2	25865	broad.mit.edu	37	19	47200991	47200991	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47200991A>G	ENST00000433867.1	-	9	1715	c.1239_splice	c.e9+1	p.L413_splice	PRKD2_ENST00000291281.4_Splice_Site_p.L413_splice|PRKD2_ENST00000601806.1_Splice_Site_p.L256_splice|PRKD2_ENST00000600194.1_Splice_Site_p.L256_splice|PRKD2_ENST00000595515.1_Splice_Site_p.L413_splice	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	413	PH.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		gccACTCACCAGCGTGTCCTT	0.662000													37	89					0	0	1	0	0
PIFO	128344	broad.mit.edu	37	1	111889591	111889591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111889591C>T	ENST00000369738.4	+	2	444	c.79C>T	c.(79-81)Cat>Tat	p.H27Y	PIFO_ENST00000369737.4_Missense_Mutation_p.H27Y|PIFO_ENST00000484512.1_3'UTR	NM_181643.4	NP_857594.2			primary cilia formation																		TCCTCACTTCCATCCCCCGAA	0.488000													24	67					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108124224	108124224	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108124224C>T	ENST00000273353.3	-	34	4813	c.4757G>A	c.(4756-4758)aGa>aAa	p.R1586K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1586						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TGAAAGCTTTCTTTCAAGTTC	0.328000													22	26					0	0	1	0	0
MYL12A	10627	broad.mit.edu	37	18	3253251	3253251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3253251G>A	ENST00000217652.3	+	2	401	c.6G>A	c.(4-6)tcG>tcA	p.S2S	MYL12A_ENST00000578611.1_Silent_p.S2S|MYL12A_ENST00000536605.1_Silent_p.S2S|MYL12A_ENST00000579226.1_Silent_p.S2S|MYL12A_ENST00000580887.1_Silent_p.S8S	NM_006471.2	NP_006462.1	P19105	ML12A_HUMAN	myosin, light chain 12A, regulatory, non-sarcomeric	2						myosin complex	calcium ion binding|protein binding			NS(1)|kidney(2)|large_intestine(2)	5						CCACCATGTCGAGCAAAAGAA	0.378000													33	129					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131515789	131515789	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131515789A>G	ENST00000291900.2	-	4	806	c.400T>C	c.(400-402)Ttg>Ctg	p.L134L	ZER1_ENST00000494461.1_5'UTR	NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	134					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						AAGAGGCTCAAGGACACCAGG	0.567000													8	46					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126676290	126676290	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:126676290C>A	ENST00000274473.6	+	5	554	c.287C>A	c.(286-288)cCt>cAt	p.P96H	MEGF10_ENST00000418761.2_Missense_Mutation_p.P96H|MEGF10_ENST00000503335.2_Missense_Mutation_p.P96H|MEGF10_ENST00000508365.1_Missense_Mutation_p.P96H	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	96	EMI.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CAGTGTTGTCCTGGATTTTAT	0.428000													36	73					1.57019e-19	1.57979e-19	1	1	0
RAI2	10742	broad.mit.edu	37	X	17819535	17819535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:17819535C>T	ENST00000545871.1	-	3	1056	c.596G>A	c.(595-597)gGg>gAg	p.G199E	RAI2_ENST00000360011.1_Missense_Mutation_p.G199E|RAI2_ENST00000331511.1_Missense_Mutation_p.G199E|RAI2_ENST00000451717.1_Missense_Mutation_p.G199E|RAI2_ENST00000415486.3_Missense_Mutation_p.G149E	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	199					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					GGGTGGGGGCCCGAGAGTGCC	0.647000													18	20					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130846099	130846099	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130846099G>A	ENST00000245255.3	+	16	2195	c.1923G>A	c.(1921-1923)cgG>cgA	p.R641R		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	641	Piwi.|RNA-binding (By similarity).				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CAGCTGGGCGGAGGTCAATCG	0.483000													14	98					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141709478	141709478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141709478G>A	ENST00000389484.3	-	19	3890	c.2919C>T	c.(2917-2919)ttC>ttT	p.F973F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	973	LDL-receptor class A 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTGCATACGAATTGGGTTA	0.418000										TSP Lung(27;0.18)			19	52					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204588011	204588011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204588011G>A	ENST00000367175.1	-	1	3322	c.1110C>T	c.(1108-1110)ccC>ccT	p.P370P	LRRN2_ENST00000367176.3_Silent_p.P370P|LRRN2_ENST00000367177.3_Silent_p.P370P			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	370	LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			CACAGCGGATGGGGTTGCCGT	0.637000													25	69					0	0	1	0	0
NAT16	375607	broad.mit.edu	37	7	100815389	100815389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100815389C>T	ENST00000300303.2	-	4	1319	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	NAT16_ENST00000455377.1_Missense_Mutation_p.E361K	NM_198571.2	NP_940973.2	Q8N8M0	CG052_HUMAN	N-acetyltransferase 16 (GCN5-related, putative)	361							N-acetyltransferase activity										AGGTACTGTTCAGTATAACCC	0.622000													17	51					0	0	1	0	0
MYOZ2	51778	broad.mit.edu	37	4	120079232	120079232	+	Missense_Mutation	SNP	C	C	T	rs138061447		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:120079232C>T	ENST00000307128.5	+	4	515	c.302C>T	c.(301-303)tCg>tTg	p.S101L		NM_016599.4	NP_057683.1	Q9NPC6	MYOZ2_HUMAN	myozenin 2	101							protein phosphatase 2B binding			endometrium(1)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						GAAGGTGGTTCGCAGCAAGCC	0.463000													53	118					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107743504	107743504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107743504G>A	ENST00000388781.3	-	10	1248	c.1165C>T	c.(1165-1167)Ccc>Tcc	p.P389S	LAMB4_ENST00000205386.4_Missense_Mutation_p.P389S|LAMB4_ENST00000414450.2_Missense_Mutation_p.P389S|LAMB4_ENST00000388780.3_Missense_Mutation_p.P389S	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	389	Laminin EGF-like 2.				cell adhesion	basement membrane		p.P389S(2)		NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CACGCGTAGGGATCTGAGATG	0.597000													9	24					0	0	1	0	0
IL5	3567	broad.mit.edu	37	5	131878811	131878811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131878811C>T	ENST00000231454.1	-	2	195	c.152G>A	c.(151-153)aGg>aAg	p.R51K		NM_000879.2	NP_000870.1	P05113	IL5_HUMAN	interleukin 5 (colony-stimulating factor, eosinophil)	51					immune response|inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of podosome assembly	extracellular space	cytokine activity|growth factor activity|interleukin-5 receptor binding			endometrium(1)|large_intestine(1)|stomach(1)|upper_aerodigestive_tract(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Pranlukast(DB01411)	AACAGGAATCCTCAGAGTCTG	0.328000													11	46					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89985834	89985834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89985834G>A	ENST00000405460.2	+	30	6743	c.6647G>A	c.(6646-6648)gGg>gAg	p.G2216E		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2216					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCCAGACTAGGGGCTTTAACA	0.393000													6	7					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29294506	29294506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29294506C>T	ENST00000331664.5	-	1	2621	c.2622G>A	c.(2620-2622)agG>agA	p.R874R		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	874					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CCCATGTTCTCCTGGTGGGGC	0.627000													23	66					0	0	1	0	0
IGLV7-43	28776	broad.mit.edu	37	22	22749636	22749636	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22749636C>T	ENST00000390298.2	+	0	194																											TGGTTACTATCCAAACTGGTT	0.557000													13	51					0	0	1	0	0
GGT5	2687	broad.mit.edu	37	22	24621549	24621549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24621549C>T	ENST00000327365.4	-	9	1717	c.1301G>A	c.(1300-1302)cGa>cAa	p.R434Q	GGT5_ENST00000398292.3_Missense_Mutation_p.R434Q|GGT5_ENST00000418439.2_Missense_Mutation_p.R357Q|GGT5_ENST00000263112.7_Missense_Mutation_p.R402Q	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	434					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						CCGGGGGCATCGCTCGCATAA	0.647000													8	33					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42678454	42678454	+	Missense_Mutation	SNP	G	G	A	rs35855730		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42678454G>A	ENST00000397163.3	+	3	688	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K	CAPN3_ENST00000349748.3_Missense_Mutation_p.E157K|CAPN3_ENST00000318023.7_Missense_Mutation_p.E157K|CAPN3_ENST00000356316.3_Missense_Mutation_p.E70K|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000357568.3_Missense_Mutation_p.E157K	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	157	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		AAGTTTCATCGAAAACTACGC	0.552000											OREG0023085	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	120					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39265901	39265901	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39265901C>T	ENST00000280481.7	+	1	4636	c.4420C>T	c.(4420-4422)Cag>Tag	p.Q1474*		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1474					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ATGCACGGATCAGCCTGGTGT	0.468000													21	62					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219249889	219249889	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219249889G>A	ENST00000233202.6	+	4	633	c.293G>A	c.(292-294)tGg>tAg	p.W98*	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	98					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGCTGCTCTGGGCCACCGTG	0.622000													9	91					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	117072882	117072882	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117072882C>T	ENST00000356083.3	+	61	5881	c.5490C>T	c.(5488-5490)ccC>ccT	p.P1830P		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1830	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CCCAAGACCCCCAACAGCTGC	0.557000													10	77					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78471031	78471031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78471031C>T	ENST00000258873.4	-	11	1832	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K	ACSBG1_ENST00000560817.1_Missense_Mutation_p.E301K|ACSBG1_ENST00000541759.1_Missense_Mutation_p.E301K	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	543					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						AGCCAGCCTTCCTCGTCGATG	0.627000													6	41					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151105854	151105854	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151105854G>A	ENST00000341697.3	-	19	3590	c.1899C>T	c.(1897-1899)caC>caT	p.H633H				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	633						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCGACGTCGGTGGGCGCGGC	0.726000													7	15					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47241496	47241496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47241496C>T	ENST00000300404.2	+	8	1052	c.993C>T	c.(991-993)ctC>ctT	p.L331L	B4GALNT2_ENST00000504681.1_Silent_p.L245L|B4GALNT2_ENST00000393354.2_Silent_p.L271L	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	331					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			AGACTTTCCTCCGCCCCCACA	0.507000													43	189					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62291316	62291316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62291316G>A	ENST00000258991.3	-	2	346	c.262C>T	c.(262-264)Cct>Tct	p.P88S	TEX2_ENST00000584379.1_Missense_Mutation_p.P88S|TEX2_ENST00000583097.1_Missense_Mutation_p.P88S			Q8IWB9	TEX2_HUMAN	testis expressed 2	88					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		GAGGCAGCAGGGCCGGCGGGG	0.582000													82	209					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42989105	42989105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42989105C>T	ENST00000253408.5	-	5	906	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K	GFAP_ENST00000586793.1_Missense_Mutation_p.E281K|GFAP_ENST00000588735.1_Intron|GFAP_ENST00000435360.2_Missense_Mutation_p.E281K	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	281	Coil 2B.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				TCGTTGGCTTCGTGCTTGGCC	0.682000													19	29					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17197380	17197380	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:17197380G>A	ENST00000285681.2	+	12	1673	c.1304_splice	c.e12+1	p.R435_splice	USP25_ENST00000400183.2_Splice_Site_p.R435_splice|USP25_ENST00000351097.5_Intron|USP25_ENST00000285679.6_Splice_Site_p.R435_splice			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	435					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		AGGCTAGAAAGGTATTTTAAC	0.294000													7	51					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16895655	16895655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16895655G>A	ENST00000430580.2	-	23	3414	c.2527C>T	c.(2527-2529)Cct>Tct	p.P843S	NBPF1_ENST00000432949.1_Intron|NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000287968.8_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	843	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AACATTTCAGGAGGAATTGAG	0.512000													40	661					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20782849	20782849	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20782849C>T	ENST00000359062.3	+	6	1588	c.1548C>T	c.(1546-1548)ctC>ctT	p.L516L	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	516					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CAGGTGCCCTCGCTAAAATTT	0.438000													33	85					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11007806	11007806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11007806G>A	ENST00000377004.4	-	12	2385	c.2386C>T	c.(2386-2388)Ccc>Tcc	p.P796S	C1orf127_ENST00000377008.4_Missense_Mutation_p.P629S	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	647										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GCCAAGGTGGGCTCTGTCAGC	0.632000													7	17					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115529650	115529650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115529650C>T	ENST00000361048.1	+	7	870	c.543C>T	c.(541-543)ctC>ctT	p.L181L	PLEKHS1_ENST00000369312.4_Silent_p.L93L|PLEKHS1_ENST00000369310.3_Silent_p.L175L	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		GAAATGGTCTCCAAGACAAGG	0.473000													42	101					0	0	1	0	0
TM6SF1	53346	broad.mit.edu	37	15	83793490	83793490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83793490C>T	ENST00000322019.9	+	7	944	c.670C>T	c.(670-672)Ctc>Ttc	p.L224F	TM6SF1_ENST00000379386.4_Missense_Mutation_p.L227F|TM6SF1_ENST00000379390.6_Intron|TM6SF1_ENST00000565774.1_Missense_Mutation_p.L224F			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	224						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						GGTTGTGTGTCTCCTCCTGGC	0.398000													33	221					0	0	1	0	0
ZC3H13	23091	broad.mit.edu	37	13	46563104	46563104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46563104G>A	ENST00000242848.4	-	9	1421	c.1073C>T	c.(1072-1074)tCt>tTt	p.S358F	ZC3H13_ENST00000282007.3_Missense_Mutation_p.S358F			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	358	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CCGCTGATAAGATGGTGAAGG	0.448000													13	37					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43972278	43972278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43972278C>T	ENST00000262726.7	-	26	3572	c.3319G>A	c.(3319-3321)Gac>Aac	p.D1107N	EFCAB6_ENST00000396231.2_Missense_Mutation_p.D955N	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TACTGATTGTCCGTTAGTTTG	0.333000													28	70					0	0	1	0	0
SAMD14	201191	broad.mit.edu	37	17	48191778	48191778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48191778C>T	ENST00000503131.1	-	8	1226	c.849G>A	c.(847-849)gaG>gaA	p.E283E	SAMD14_ENST00000330175.4_Intron	NM_174920.3	NP_777580.1	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	274										breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	15						TGCTCAGTGCCTCCTGTGCAT	0.577000													11	52					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21789343	21789343	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21789343C>T	ENST00000328843.6	+	54	8773	c.8742C>T	c.(8740-8742)ccC>ccT	p.P2914P	DNAH11_ENST00000409508.3_Silent_p.P2907P			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2914	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGAACATGCCCACTGTGTTCC	0.458000									Kartagener syndrome				11	49					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62659058	62659058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62659058C>T	ENST00000535781.1	+	16	2299	c.2188C>T	c.(2188-2190)Cgt>Tgt	p.R730C	ZNF512B_ENST00000450537.1_Intron|ZNF512B_ENST00000217130.3_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	770					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GGAAAAGTCTCGTCTGAAGAA	0.607000													58	145					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36488689	36488689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36488689C>T	ENST00000405275.2	+	16	1708	c.1465C>T	c.(1465-1467)Cac>Tac	p.H489Y	CTNNBL1_ENST00000373473.1_Missense_Mutation_p.H329Y|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.H516Y|CTNNBL1_ENST00000473857.1_3'UTR|CTNNBL1_ENST00000373469.1_Missense_Mutation_p.H264Y			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	516					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				CCAGAGGGTTCACCAGATCCT	0.428000													62	129					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142569570	142569570	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142569570G>A	ENST00000359396.3	-	15	2313	c.2068C>T	c.(2068-2070)Cgc>Tgc	p.R690C		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	690					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding	p.R690C(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					GCACTGCTGCGGGAGGTACTT	0.567000													13	54					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7703877	7703877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:7703877G>A	ENST00000340209.4	+	9	1130	c.833G>A	c.(832-834)cGa>cAa	p.R278Q	RBFOX1_ENST00000552089.1_Missense_Mutation_p.R290Q|RBFOX1_ENST00000550418.1_Missense_Mutation_p.R273Q|RBFOX1_ENST00000535565.2_Missense_Mutation_p.R230Q|RBFOX1_ENST00000436368.2_Missense_Mutation_p.R293Q|RBFOX1_ENST00000547338.1_Missense_Mutation_p.R273Q|RBFOX1_ENST00000553186.1_Missense_Mutation_p.R246Q|RBFOX1_ENST00000311745.5_Missense_Mutation_p.R293Q|RBFOX1_ENST00000355637.4_Missense_Mutation_p.R293Q|RBFOX1_ENST00000422070.4_Missense_Mutation_p.R316Q|RBFOX1_ENST00000547372.1_Missense_Mutation_p.R316Q			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	273					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						GCGCACCTGCGAGGCCGCGGT	0.731000													19	25					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505165	37505165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37505165G>A	ENST00000374660.1	+	38	3214	c.3115G>A	c.(3115-3117)Gaa>Aaa	p.E1039K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E920K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E920K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1042						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AAGAGCAAGGGAACTTCAAAA	0.323000													21	69					0	0	1	0	0
ADH1A	124	broad.mit.edu	37	4	100205629	100205629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100205629G>A	ENST00000209668.2	-	5	607	c.494C>T	c.(493-495)tCg>tTg	p.S165L	RP11-696N14.1_ENST00000500358.2_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	165					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CTCTAGAGGCGAGGCTGCATC	0.478000													25	74					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18022300	18022300	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18022300C>T	ENST00000205890.5	+	2	524	c.186C>T	c.(184-186)ggC>ggT	p.G62G		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	62	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCTTCTGGGGCCTCCACACCG	0.632000													8	13					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104510873	104510873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104510873C>T	ENST00000304883.2	-	5	1504	c.1364G>A	c.(1363-1365)aGc>aAc	p.S455N	RP11-297P16.3_ENST00000502936.1_RNA|RP11-297P16.3_ENST00000512401.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	455						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		ATAGGGTGAGCTTATGAAACT	0.468000													47	135					0	0	1	0	0
MSS51	118490	broad.mit.edu	37	10	75184446	75184446	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75184446G>A	ENST00000299432.2	-	7	1313	c.1248C>T	c.(1246-1248)tcC>tcT	p.S416S	MSS51_ENST00000372912.1_Silent_p.S416S	NM_001024593.1	NP_001019764.1	Q4VC12	ZMY17_HUMAN	MSS51 mitochondrial translational activator	416							zinc ion binding										CAGGTTTGAGGGACATGAAAG	0.453000													12	115					0	0	1	0	0
CHRNA3	1136	broad.mit.edu	37	15	78894012	78894012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78894012G>A	ENST00000326828.5	-	5	1356	c.972C>T	c.(970-972)ttC>ttT	p.F324F	CHRNA3_ENST00000348639.3_Silent_p.F324F	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	324					activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CGTTGAGCACGAAGACGGTGA	0.522000													79	114					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140186830	140186830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140186830C>T	ENST00000530339.1	+	1	58	c.58C>T	c.(58-60)Ctc>Ttc	p.L20F	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.L20F|PCDHA4_ENST00000512229.2_Missense_Mutation_p.L20F|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTACTTCTTCTCCTCGCAGC	0.567000													53	125					0	0	1	0	0
IGKV1D-43	28891	broad.mit.edu	37	2	90249169	90249169	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90249169C>A	ENST00000468879.1	+	0	306																											GACAGAGTCACCATCACTTGC	0.473000													45	188					4.75955e-12	4.78136e-12	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105414114	105414114	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105414114C>T	ENST00000333244.5	-	7	7793	c.7674G>A	c.(7672-7674)gaG>gaA	p.E2558E	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2558						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCCGGCTCCCTCCGGCACAG	0.627000													93	198					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248486954	248486954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248486954C>T	ENST00000317965.2	-	1	945	c.917G>A	c.(916-918)gGa>gAa	p.G306E		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTGCCCTTTCCTAAGATTTT	0.388000													13	61					0	0	1	0	0
WNT7B	7477	broad.mit.edu	37	22	46318801	46318801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46318801G>A	ENST00000339464.4	-	4	1359	c.985C>T	c.(985-987)Cac>Tac	p.H329Y	WNT7B_ENST00000409496.3_Missense_Mutation_p.H333Y|WNT7B_ENST00000410089.1_Missense_Mutation_p.H313Y	NM_058238.2	NP_478679.1	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family, member 7B	329					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	19		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCACCAGTGGAATTTGCAG	0.657000													27	73					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30740440	30740440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30740440C>T	ENST00000262518.4	+	26	6197	c.5812C>T	c.(5812-5814)Cct>Tct	p.P1938S	SRCAP_ENST00000395059.2_Missense_Mutation_p.P1876S|SRCAP_ENST00000344771.4_Missense_Mutation_p.P1780S	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1938					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCCCATCGGCCCTCGTTCTCC	0.597000													28	67					0	0	1	0	0
PTK6	5753	broad.mit.edu	37	20	62165016	62165016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62165016C>T	ENST00000217185.2	-	4	585	c.558G>A	c.(556-558)agG>agA	p.R186R	PTK6_ENST00000542869.1_Silent_p.R85R	NM_005975.3	NP_005966.1	Q13882	PTK6_HUMAN	protein tyrosine kinase 6	186						cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(3)|kidney(1)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	15	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CCTCCCTCGGCCTCTCCCAGT	0.632000													42	85					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345295	20345295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20345295G>A	ENST00000298642.2	+	1	905	c.869G>A	c.(868-870)aGg>aAg	p.R290K		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TATACTTTGAGGAATCAAGAA	0.358000													20	60					0	0	1	0	0
GABBR2	9568	broad.mit.edu	37	9	101052900	101052900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101052900G>A	ENST00000259455.2	-	19	3251	c.2792C>T	c.(2791-2793)cCa>cTa	p.P931L		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	931					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GAAGGAGGGTGGCACATGTCT	0.692000													7	8					0	0	1	0	0
ZNF660	285349	broad.mit.edu	37	3	44635928	44635928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44635928G>A	ENST00000322734.2	+	3	576	c.243G>A	c.(241-243)aaG>aaA	p.K81K	RP11-944L7.4_ENST00000457331.1_RNA	NM_173658.2	NP_775929.2	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		ATAAGTGTAAGGAGTGTGGAA	0.448000													24	80					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96466679	96466679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96466679C>T	ENST00000285979.6	+	5	980	c.781C>T	c.(781-783)Cgg>Tgg	p.R261W	CYP2C18_ENST00000339022.5_Intron|CYP2C19_ENST00000464755.1_3'UTR	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GAACAGTGCTCGGGACTTTAT	0.328000													31	69					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14607558	14607558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14607558G>A	ENST00000274217.3	+	6	738	c.618G>A	c.(616-618)ttG>ttA	p.L206L		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	206										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					TGGAATTATTGAAAACACAGG	0.393000													24	62					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7976593	7976593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7976593C>T	ENST00000319144.4	-	14	2059	c.1799G>A	c.(1798-1800)cGg>cAg	p.R600Q	ALOX12B_ENST00000577351.1_5'UTR	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	600	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						CGGTGGATTCCGCATGGACGC	0.587000										Multiple Myeloma(8;0.094)			89	129					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23815352	23815352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:23815352C>T	ENST00000264867.2	-	8	1873	c.1754G>A	c.(1753-1755)aGg>aAg	p.R585K	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	585	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TGATCTTGACCTGGAATATGG	0.428000													13	51					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110791056	110791056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110791056C>T	ENST00000327908.3	+	4	1366	c.602C>T	c.(601-603)tCa>tTa	p.S201L	LRIT3_ENST00000409621.2_Missense_Mutation_p.S201L|LRIT3_ENST00000379920.3_Missense_Mutation_p.S339L|LRIT3_ENST00000594814.1_Missense_Mutation_p.S384L			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	339	LRRCT.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		AGCGCATCATCATATCTTTGG	0.468000													56	133					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51387809	51387809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51387809C>T	ENST00000266037.9	+	40	4116	c.4093C>T	c.(4093-4095)Cct>Tct	p.P1365S		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1365	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAGGAAGTTTCCTTTCTTTCT	0.428000													45	103					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177632728	177632728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:177632728C>T	ENST00000280193.2	-	4	1044	c.629G>A	c.(628-630)cGa>cAa	p.R210Q	VEGFC_ENST00000507638.1_5'UTR	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	210					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		AGACATGCATCGGCAGGAAGT	0.393000													10	130					0	0	1	0	0
KY	339855	broad.mit.edu	37	3	134366313	134366313	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134366313G>A	ENST00000508956.1	-	2	220	c.163C>T	c.(163-165)Cga>Tga	p.R55*	KY_ENST00000503669.1_Nonsense_Mutation_p.R55*|KY_ENST00000423778.2_Nonsense_Mutation_p.R55*			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	55						cytoskeleton|Z disc	peptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						TGCCATCTTCGGACTCCATTT	0.383000													12	16					0	0	1	0	0
REST	5978	broad.mit.edu	37	4	57796460	57796460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:57796460C>T	ENST00000309042.7	+	4	1750	c.1436C>T	c.(1435-1437)cCt>cTt	p.P479L		NM_001193508.1|NM_005612.4	NP_001180437.1|NP_005603.3	Q13127	REST_HUMAN	RE1-silencing transcription factor	479	Lys-rich.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	50	Glioma(25;0.08)|all_neural(26;0.181)					GAGAAAAAGCCTTCTAATAAT	0.373000													4	52					0	0	1	0	0
OBP2A	29991	broad.mit.edu	37	9	138438674	138438674	+	Silent	SNP	G	G	A	rs142617413	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138438674G>A	ENST00000539850.1	+	2	149	c.123G>A	c.(121-123)ccG>ccA	p.P41P	OBP2A_ENST00000371776.1_Silent_p.P41P|OBP2A_ENST00000340780.3_Silent_p.P41P|OBP2A_ENST00000342114.4_Intron			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	41					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		AGGACTTTCCGGAGGACAGGA	0.602000													9	19					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1940297	1940297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1940297C>T	ENST00000543818.1	+	4	1106	c.264C>T	c.(262-264)ttC>ttT	p.F88F	LRTM2_ENST00000543730.1_Intron|LRTM2_ENST00000535041.1_Silent_p.F88F|LRTM2_ENST00000299194.1_Silent_p.F88F|CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000382722.5_Intron|CACNA2D4_ENST00000585732.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	88						integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GCTGGGCTTTCGCCAACCTCT	0.622000													7	125					0	0	1	0	0
PLA2G2D	26279	broad.mit.edu	37	1	20440676	20440676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20440676C>T	ENST00000375105.3	-	4	427	c.369G>A	c.(367-369)ctG>ctA	p.L123L		NM_012400.2	NP_036532.1	Q9UNK4	PA2GD_HUMAN	phospholipase A2, group IID	123					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(1)|lung(2)	3		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000798)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGTAGGTGTCCAGGTTGCGCT	0.622000										Multiple Myeloma(11;0.12)			16	51					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204946817	204946817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204946817G>A	ENST00000367172.4	+	17	2168	c.1840G>A	c.(1840-1842)Gcc>Acc	p.A614T	NFASC_ENST00000404076.1_Intron|NFASC_ENST00000513543.1_Intron|NFASC_ENST00000367171.4_Intron|NFASC_ENST00000339876.6_Missense_Mutation_p.A614T|NFASC_ENST00000539706.1_Intron|NFASC_ENST00000404907.1_Intron|NFASC_ENST00000360049.4_Intron|NFASC_ENST00000367170.4_Missense_Mutation_p.A614T|NFASC_ENST00000401399.1_Missense_Mutation_p.A614T|NFASC_ENST00000367169.4_Missense_Mutation_p.A614T|NFASC_ENST00000338586.6_Missense_Mutation_p.A614T|NFASC_ENST00000338515.6_Missense_Mutation_p.A614T			O94856	NFASC_HUMAN	neurofascin	614					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGCTGATCAGGCCACTCCAAC	0.537000													11	34					0	0	1	0	0
LPAL2	80350	broad.mit.edu	37	6	160905242	160905242	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160905242G>A	ENST00000335388.5	-	0	885					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GCCTTCCACAGGATCTGGATT	0.512000													33	43					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108813814	108813814	+	Silent	SNP	G	G	A	rs145413382		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108813814G>A	ENST00000232603.5	-	7	607	c.525C>T	c.(523-525)tcC>tcT	p.S175S	MORC1_ENST00000483760.1_Silent_p.S175S	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	175					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTTTAAATGGGGAGTATTTAT	0.343000													15	41					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10910355	10910355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10910355G>A	ENST00000298232.7	-	21	1714	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F	TPTE_ENST00000361285.4_Silent_p.F467F|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.F429F	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	467	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAGACCGTCGAATACATCAA	0.338000													19	132					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52539139	52539139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52539139G>A	ENST00000242839.4	-	5	1894	c.1738C>T	c.(1738-1740)Cac>Tac	p.H580Y	ATP7B_ENST00000418097.2_Missense_Mutation_p.H580Y|ATP7B_ENST00000344297.5_Missense_Mutation_p.H580Y|ATP7B_ENST00000542656.1_Intron|ATP7B_ENST00000448424.2_Missense_Mutation_p.H580Y|ATP7B_ENST00000400370.3_Intron|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000400366.3_Missense_Mutation_p.H469Y	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	580	HMA 6.				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding	p.H580N(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TCTATGTTGTGGACACAGGAC	0.517000									Wilson disease				32	60					0	0	1	0	0
GSTA3	2940	broad.mit.edu	37	6	52764807	52764807	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52764807T>A	ENST00000211122.3	-	5	404	c.339A>T	c.(337-339)cgA>cgT	p.R113R	GSTA3_ENST00000370968.1_Silent_p.R63R	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	113	GST C-terminal.		R -> Q.	RP -> PA (in Ref. 1; AAA74634).	glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	TTTCCTCAGGTCGACATAAGG	0.393000													103	223					0	0	1	0	0
NUMBL	9253	broad.mit.edu	37	19	41188694	41188694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41188694G>A	ENST00000252891.4	-	5	505	c.338C>T	c.(337-339)tCc>tTc	p.S113F	NUMBL_ENST00000540131.1_Missense_Mutation_p.S72F|NUMBL_ENST00000598779.1_Missense_Mutation_p.S72F	NM_004756.3	NP_004747.1	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	113	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)	16			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			AGACTTCACGGACTTTCGGCC	0.652000													19	60					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810341	106810341	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:106810341G>A	ENST00000526355.1	-	4	1519	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	GUCY1A2_ENST00000282249.2_Nonsense_Mutation_p.R351*|GUCY1A2_ENST00000347596.2_Nonsense_Mutation_p.R351*	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	351					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GTGTCACATCGAAGCTGCTTC	0.473000													21	34					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256171	15256171	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15256171C>T	ENST00000378116.4	-	8	1422	c.1416G>A	c.(1414-1416)atG>atA	p.M472I	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	472						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CTTCTCTTTCCATAGATTTTC	0.468000													31	65					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724283	7724283	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:7724283C>T	ENST00000303635.7	+	9	1883	c.1676C>T	c.(1675-1677)tCc>tTc	p.S559F	CAMTA1_ENST00000439411.2_Missense_Mutation_p.S559F	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCAGCCAGCTCCCTCACCCTG	0.662000			T	WWTR1	epitheliod hemangioendothelioma								21	66					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101590503	101590503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101590503C>T	ENST00000370449.4	+	21	2891	c.2778C>T	c.(2776-2778)tcC>tcT	p.S926S		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	926						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ATCTGAAGTCCCTGAGAAACT	0.448000													34	63					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62192546	62192546	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62192546G>A	ENST00000467148.1	-	14	7104	c.7035C>T	c.(7033-7035)gcC>gcT	p.A2345A	HELZ2_ENST00000427522.2_Silent_p.A1776A	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GGCTGGCAGAGGCTGCACAGG	0.602000													12	87					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6312195	6312195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6312195G>A	ENST00000301452.4	-	3	392	c.315C>T	c.(313-315)ccC>ccT	p.P105P		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	105						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						AATAGCAGCGGGGCATCCATA	0.582000													14	47					0	0	1	0	0
DHRS4L1	728635	broad.mit.edu	37	14	24511906	24511906	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24511906C>T	ENST00000558293.1	+	0	437					NR_102693.1				dehydrogenase/reductase (SDR family) member 4 like 1																		GGCTATGAAGCTTCATGGAGT	0.448000													52	203					0	0	1	0	0
ZNF559	84527	broad.mit.edu	37	19	9449179	9449179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9449179C>T	ENST00000587557.1	+	3	553	c.146C>T	c.(145-147)tCt>tTt	p.S49F	ZNF559_ENST00000603380.1_5'UTR|ZNF177_ENST00000541595.2_5'UTR|ZNF177_ENST00000602738.1_5'UTR|ZNF559_ENST00000586255.1_Missense_Mutation_p.S13F|ZNF177_ENST00000602856.1_Intron|ZNF559_ENST00000592896.1_Missense_Mutation_p.S13F|ZNF559_ENST00000317221.7_5'UTR|ZNF559_ENST00000393883.2_5'UTR|ZNF559_ENST00000592504.1_5'UTR|ZNF177_ENST00000605471.1_Intron|ZNF559_ENST00000585352.1_5'UTR|ZNF177_ENST00000446085.4_Intron|ZNF559_ENST00000538743.1_Intron	NM_001202406.1|NM_001202408.1|NM_001202409.1|NM_001202411.1	NP_001189335.1|NP_001189337.1|NP_001189338.1|NP_001189340.1	Q9BR84	ZN559_HUMAN	zinc finger protein 559	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						GATCATCTTTCTCAAGATGTT	0.388000													24	40					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66190294	66190294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66190294C>T	ENST00000311034.2	+	4	756	c.580C>T	c.(580-582)Cct>Tct	p.P194S		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	194					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						TTTCTGTGCCCCTCTGGAGCC	0.622000													20	107					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40713344	40713344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40713344C>T	ENST00000373198.3	-	30	4415	c.4180G>A	c.(4180-4182)Gga>Aga	p.G1394R	PTPRT_ENST00000373193.3_Missense_Mutation_p.G1375R|PTPRT_ENST00000373184.1_Missense_Mutation_p.G1382R|PTPRT_ENST00000373201.1_Missense_Mutation_p.G1362R|PTPRT_ENST00000373190.1_Missense_Mutation_p.G1371R|PTPRT_ENST00000373187.1_Missense_Mutation_p.G1372R|PTPRT_ENST00000356100.2_Missense_Mutation_p.G1381R	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1372	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACAGTACGTCCCTCCCTCCCG	0.607000													8	31					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14749141	14749141	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14749141G>A	ENST00000253673.5	-	11	1360	c.1260C>T	c.(1258-1260)tcC>tcT	p.S420S	EMR3_ENST00000443157.2_Silent_p.S294S|EMR3_ENST00000599900.1_Silent_p.S205S|EMR3_ENST00000344373.4_Silent_p.S368S	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	420					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						CGGCGATGATGGAGCACAGCA	0.587000													8	37					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018170	62018170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62018170C>T	ENST00000578147.1	-	24	5548	c.5472G>A	c.(5470-5472)ggG>ggA	p.G1824G	SCN4A_ENST00000435607.1_Silent_p.G1824G			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1824					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GCACAGTCTGCCCTGGGGGAG	0.687000													6	64					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123451818	123451818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123451818C>T	ENST00000360772.3	-	12	1819	c.1441G>A	c.(1441-1443)Gac>Aac	p.D481N	MYLK_ENST00000346322.5_Intron|MYLK_ENST00000359169.1_Missense_Mutation_p.D481N|MYLK_ENST00000475616.1_Missense_Mutation_p.D481N|MYLK_ENST00000360304.3_Missense_Mutation_p.D481N			Q15746	MYLK_HUMAN	myosin light chain kinase	481	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GTCCCACTGTCCCTGGTCCGG	0.577000													13	54					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44676097	44676097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44676097C>T	ENST00000454036.1	+	15	1937	c.1861C>T	c.(1861-1863)Ctc>Ttc	p.L621F	SLC12A5_ENST00000539566.1_3'UTR|SLC12A5_ENST00000243964.3_Missense_Mutation_p.L598F	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	621					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTCTAGGACCCTCTCCTTCCT	0.572000													38	108					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681549	55681549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55681549C>T	ENST00000344514.1	-	1	509	c.510G>A	c.(508-510)ggG>ggA	p.G170G		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TCTCATTAGACCCACAGAAGC	0.433000													15	118					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105026744	105026744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:105026744C>T	ENST00000507740.1	+	17	2913	c.2677C>T	c.(2677-2679)Cgt>Tgt	p.R893C	RIMS2_ENST00000406091.3_Missense_Mutation_p.R1079C|RIMS2_ENST00000262231.10_Missense_Mutation_p.R918C|RIMS2_ENST00000436393.2_Missense_Mutation_p.R819C	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1141	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GTCTCATCCTCGTACTGGGTC	0.418000										HNSCC(12;0.0054)			12	49					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198725306	198725306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:198725306C>T	ENST00000367376.2	+	33	4082	c.3911C>T	c.(3910-3912)tCa>tTa	p.S1304L	PTPRC_ENST00000594404.1_Missense_Mutation_p.S1143L|PTPRC_ENST00000442510.2_Missense_Mutation_p.S1306L|PTPRC_ENST00000352140.3_Missense_Mutation_p.S1256L|PTPRC_ENST00000348564.6_Missense_Mutation_p.S1145L	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1304					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AATCAAGGTTCATAGGAAAAG	0.413000													17	40					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92442776	92442776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92442776G>A	ENST00000370389.2	+	6	1500	c.576G>A	c.(574-576)aaG>aaA	p.K192K	BRDT_ENST00000362005.3_Silent_p.K265K|BRDT_ENST00000484781.1_3'UTR|BRDT_ENST00000399546.2_Silent_p.K265K|BRDT_ENST00000394530.3_Silent_p.K219K|BRDT_ENST00000402388.1_Silent_p.K265K	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		ATGTTGTGAAGACTGTTAAAG	0.348000													22	69					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136610419	136610419	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136610419G>A	ENST00000264156.2	-	12	1753	c.1693C>T	c.(1693-1695)Cgt>Tgt	p.R565C	MCM6_ENST00000492091.1_Intron	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	565					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	GAATAGACACGATCAATTGAT	0.368000													23	51					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180359940	180359940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:180359940C>T	ENST00000273654.4	-	19	2586	c.1967G>A	c.(1966-1968)cGa>cAa	p.R656Q	CCDC39_ENST00000442201.2_Missense_Mutation_p.R572Q			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	572					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AAGCATTTCTCGAGTACGCTT	0.323000													10	24					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115422330	115422330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:115422330C>T	ENST00000337530.6	+	4	2428	c.2132C>T	c.(2131-2133)tCc>tTc	p.S711F	KIAA1958_ENST00000536272.1_Missense_Mutation_p.S739F	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	711										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						AGGCTTGGCTCCCACAGCTGC	0.612000													27	74					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113171163	113171163	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113171163T>G	ENST00000401783.2	-	38	7053	c.6717A>C	c.(6715-6717)ggA>ggC	p.G2239G	SVEP1_ENST00000374469.1_Silent_p.G2216G|SVEP1_ENST00000297826.5_Silent_p.G165G	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2239	Sushi 14.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ATACAGGACTTCCGACTGACT	0.507000													17	140					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42458405	42458405	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42458405G>A	ENST00000318006.5	-	16	1794	c.1632C>T	c.(1630-1632)ttC>ttT	p.F544F	VPS39_ENST00000348544.4_Silent_p.F555F	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	555					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		CTGAGTAGGAGAAAATCAAAT	0.512000													21	63					0	0	1	0	0
TRMT10A	93587	broad.mit.edu	37	4	100472066	100472066	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100472066G>A	ENST00000273962.3	-	7	1039	c.727C>T	c.(727-729)Cga>Tga	p.R243*	TRMT10A_ENST00000394876.2_Nonsense_Mutation_p.R243*|TRMT10A_ENST00000394877.3_Nonsense_Mutation_p.R243*	NM_152292.4	NP_689505.1			tRNA methyltransferase 10 homolog A (S. cerevisiae)																		AAAACTTTTCGACTATTCATC	0.348000													10	27					0	0	1	0	0
IL1B	3553	broad.mit.edu	37	2	113587942	113587942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113587942G>A	ENST00000263341.2	-	7	1016	c.806C>T	c.(805-807)tCc>tTc	p.S269F	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	269					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	CTCTCTTTAGGAAGACACAAA	0.502000													24	100					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130788431	130788431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:130788431C>T	ENST00000276708.4	-	3	1202	c.321G>A	c.(319-321)ggG>ggA	p.G107G		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	107						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CAGAGGCCTCCCCTGACACAC	0.478000													20	89					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88583166	88583166	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88583166C>T	ENST00000418177.2	-	3	1186	c.819G>A	c.(817-819)gtG>gtA	p.V273V	GRM5_ENST00000305447.4_Silent_p.V273V|GRM5_ENST00000393297.1_Silent_p.V273V|GRM5_ENST00000455756.2_Silent_p.V273V|GRM5_ENST00000305432.5_Silent_p.V273V			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	273					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AGCAGGCCACCACCCGGGCCT	0.552000													28	62					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89943398	89943398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89943398G>A	ENST00000405460.2	+	17	3202	c.3106G>A	c.(3106-3108)Gtc>Atc	p.V1036I		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1036					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GACTTGCATGGTCCAGTATGC	0.438000													23	73					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109695723	109695723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:109695723G>A	ENST00000465301.2	+	3	2124	c.1878G>A	c.(1876-1878)acG>acA	p.T626T	RGAG1_ENST00000540313.1_Silent_p.T626T	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	626										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						CCTCAGGAACGATGTTCACGG	0.502000													40	23					0	0	1	0	0
TTC22	55001	broad.mit.edu	37	1	55266666	55266666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55266666G>A	ENST00000371276.4	-	1	274	c.171C>T	c.(169-171)ctC>ctT	p.L57L	TTC22_ENST00000371274.4_Silent_p.L57L	NM_001114108.1	NP_001107580.1	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22	57							binding			kidney(1)|large_intestine(1)|lung(7)|skin(1)	10						CCGCCAGCTGGAGCTCCTGCC	0.701000													11	17					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5323135	5323135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5323135G>A	ENST00000380224.1	-	1	91	c.42C>T	c.(40-42)ggC>ggT	p.G14G	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCCCAAGAAGCCAGTCAGCA	0.463000											OREG0003718	type=REGULATORY REGION|Gene=OR51B4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	23	77					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95194801	95194801	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:95194801C>T	ENST00000354268.4	+	12	1679	c.1606C>T	c.(1606-1608)Ctg>Ttg	p.L536L	SMARCAD1_ENST00000457823.2_Silent_p.L536L|SMARCAD1_ENST00000509418.1_Silent_p.L106L			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	536	Helicase ATP-binding.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		CATTGCATTTCTGGCATACCT	0.308000													19	38					0	0	1	0	0
IGHV3-74	28408	broad.mit.edu	37	14	107218706	107218706	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107218706G>A	ENST00000424969.2	-	0	556																											CCGTGTCCTCGGCTCTCAGAC	0.552000													129	295					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161010697	161010697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161010697C>T	ENST00000447678.1	-	25	3955	c.3835G>A	c.(3835-3837)Gga>Aga	p.G1279R	LPA_ENST00000316300.5_Missense_Mutation_p.G1279R	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3787	Kringle 12.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TAACTCTGTCCATCACCATGG	0.473000													25	57					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43359763	43359763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43359763G>A	ENST00000401467.2	-	1	80	c.9C>T	c.(7-9)ccC>ccT	p.P3P	PSG10P_ENST00000597171.1_RNA			Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	3						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GGGCTGAGAGGGGCCCCATGG	0.582000													39	222					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3076327	3076327	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3076327C>T	ENST00000397461.1	+	16	2179	c.1795C>T	c.(1795-1797)Ccc>Tcc	p.P599S	CNTN4_ENST00000418658.1_Missense_Mutation_p.P599S|CNTN4_ENST00000448906.2_Missense_Mutation_p.P271S|CNTN4_ENST00000358480.3_Missense_Mutation_p.P380S|CNTN4_ENST00000397459.2_Missense_Mutation_p.P271S|CNTN4_ENST00000427331.1_Missense_Mutation_p.P599S	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	599	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding	p.P271S(1)|p.P599S(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TCCTCCAGGTCCCCCAGAGGC	0.527000													13	41					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70961825	70961825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70961825G>A	ENST00000357250.6	-	28	2028	c.1870C>T	c.(1870-1872)Cct>Tct	p.P624S	COL9A1_ENST00000370499.4_Missense_Mutation_p.P381S|COL9A1_ENST00000320755.7_Missense_Mutation_p.P381S|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	624	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						ATACTCACAGGAAGCCCCTGG	0.483000													56	110					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64981565	64981565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:64981565G>A	ENST00000268603.4	-	13	2947	c.2332C>T	c.(2332-2334)Cgt>Tgt	p.R778C	CDH11_ENST00000394156.3_3'UTR|CDH11_ENST00000566827.1_Missense_Mutation_p.R652C	NM_001797.2	NP_001788.2	P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	778					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TTCTTAAAACGAGGTCCCCAG	0.458000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			18	140					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21702955	21702955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21702955G>A	ENST00000388958.3	+	8	687	c.686G>A	c.(685-687)aGa>aAa	p.R229K	OTOA_ENST00000388956.4_Missense_Mutation_p.R150K|OTOA_ENST00000286149.4_Missense_Mutation_p.R229K	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	229					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		CATTCCCAGAGAGCTCTCTAT	0.488000													10	51					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48160882	48160882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:48160882C>T	ENST00000244043.4	-	4	510	c.481G>A	c.(481-483)Gag>Aag	p.E161K	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	161					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	AGACCCATCTCGTGCCAGCCA	0.597000													25	89					0	0	1	0	0
SH2D1B	117157	broad.mit.edu	37	1	162368759	162368759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:162368759G>A	ENST00000367929.2	-	3	426	c.317C>T	c.(316-318)cCc>cTc	p.P106L	SH2D1B_ENST00000359567.3_Intron	NM_053282.4	NP_444512.2	O14796	SH21B_HUMAN	SH2 domain containing 1B	106										kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TCTCAAGCTGGGGCTGGTTCT	0.408000													34	73					0	0	1	0	0
FAH	2184	broad.mit.edu	37	15	80460615	80460615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:80460615C>T	ENST00000539156.1	+	6	2591	c.353C>T	c.(352-354)cCc>cTc	p.P118L	FAH_ENST00000561421.1_Missense_Mutation_p.P188L|FAH_ENST00000558627.1_3'UTR|FAH_ENST00000407106.1_Missense_Mutation_p.P188L|FAH_ENST00000261755.5_Missense_Mutation_p.P188L			P16930	FAAA_HUMAN	fumarylacetoacetate hydrolase (fumarylacetoacetase)	188					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCTAAGCCTCCCGTATATGGT	0.493000									Tyrosinemia, type 1				18	142					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73072164	73072164	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73072164G>A	ENST00000429829.1	-	0	424					NR_001564.2																						GGTATCCACGGCCCCGTTGGG	0.438000													8	4					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179547469	179547469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179547469C>T	ENST00000589042.1	-	135	33273	c.33049G>A	c.(33049-33051)Gag>Aag	p.E11017K	TTN_ENST00000342992.6_Missense_Mutation_p.E9773K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E10700K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10700	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTCCCGCTCCTCGTATTCT	0.358000													10	200					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123888069	123888069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123888069C>T	ENST00000373855.1	+	14	2140	c.1880C>T	c.(1879-1881)aCc>aTc	p.T627I	CNTRL_ENST00000373847.1_Missense_Mutation_p.T75I|CNTRL_ENST00000373850.1_Missense_Mutation_p.T75I|CNTRL_ENST00000238341.5_Missense_Mutation_p.T627I			Q7Z7A1	CNTRL_HUMAN	centriolin	627					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						TACCTGGGGACCATTAAAGGC	0.478000													29	102					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220166353	220166353	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220166353C>T	ENST00000295718.2	-	7	1323	c.1083G>A	c.(1081-1083)ctG>ctA	p.L361L	PTPRN_ENST00000423636.2_Silent_p.L271L|PTPRN_ENST00000409251.3_Silent_p.L361L|AC114803.3_ENST00000417355.1_RNA	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	361					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GCAGCAGGGTCAGGAGTGTGG	0.637000													36	78					0	0	1	0	0
PDZD3	79849	broad.mit.edu	37	11	119058284	119058284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119058284C>T	ENST00000531114.1	+	4	1279	c.730C>T	c.(730-732)Cct>Tct	p.P244S	PDZD3_ENST00000525131.1_Missense_Mutation_p.P165S|PDZD3_ENST00000392817.2_Missense_Mutation_p.P244S|PDZD3_ENST00000322712.4_Missense_Mutation_p.P178S|PDZD3_ENST00000355547.5_Missense_Mutation_p.P178S			Q86UT5	NHRF4_HUMAN	PDZ domain containing 3	244	PDZ 2.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	14	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		CAATCAGGGTCCTTTCTGGTT	0.582000													3	8					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247694907	247694907	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247694907G>A	ENST00000366487.3	-	2	1268	c.907C>T	c.(907-909)Cgg>Tgg	p.R303W	GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000527541.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			ACCATGTGCCGGAGGGCGCTC	0.517000													21	52					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141625347	141625347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141625347C>T	ENST00000389484.3	-	27	5362	c.4391G>A	c.(4390-4392)cGa>cAa	p.R1464Q		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1464					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCATGACCTCGGATGATTTC	0.403000										TSP Lung(27;0.18)			30	96					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431712	140431712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140431712C>T	ENST00000306549.3	+	1	734	c.657C>T	c.(655-657)tcC>tcT	p.S219S		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		219	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGGCGGGTCCCCGCCTAAGT	0.592000													7	17					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165383593	165383593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165383593C>T	ENST00000263915.3	-	4	1072	c.534G>A	c.(532-534)ggG>ggA	p.G178G	GRB14_ENST00000543549.1_Silent_p.G91G	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	178	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						CTTCTTCTATCCCCCAGTTGG	0.328000													28	74					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77400934	77400934	+	Silent	SNP	G	G	A	rs149732972		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77400934G>A	ENST00000451710.3	-	21	3012	c.2775C>T	c.(2773-2775)ttC>ttT	p.F925F	TRPM6_ENST00000376864.4_Silent_p.F925F|TRPM6_ENST00000449912.2_Silent_p.F920F|TRPM6_ENST00000360774.1_Silent_p.F925F|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Silent_p.F920F|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	925					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						ATCGAAGGACGAAGCCAGCTG	0.478000													32	128					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99898318	99898318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:99898318C>T	ENST00000547776.2	-	10	1373	c.1374G>A	c.(1372-1374)atG>atA	p.M458I	ANKS1B_ENST00000547010.1_Missense_Mutation_p.M38I|ANKS1B_ENST00000329257.7_Missense_Mutation_p.M458I	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	458						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CAGCTGTGTCCATGAGATCAC	0.393000													22	28					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62768205	62768205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62768205C>T	ENST00000336232.2	-	3	559	c.424G>A	c.(424-426)Gac>Aac	p.D142N	SLC22A8_ENST00000542795.1_5'UTR|SLC22A8_ENST00000535878.1_Missense_Mutation_p.D19N|SLC22A8_ENST00000545207.1_Missense_Mutation_p.D51N|SLC22A8_ENST00000430500.2_Missense_Mutation_p.D142N|SLC22A8_ENST00000311438.8_Missense_Mutation_p.D142N	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	142					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						TCAGACAGGTCTCCAAGCACG	0.562000													17	45					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57004472	57004472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57004472C>T	ENST00000606794.1	-	1	203	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	3						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TCACCACCTTCCTCCATGCTG	0.562000													21	38					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179562850	179562850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179562850G>A	ENST00000444136.1	+	3	738	c.488G>A	c.(487-489)cGa>cAa	p.R163Q	TDRD5_ENST00000367614.1_Missense_Mutation_p.R163Q|TDRD5_ENST00000294848.8_Missense_Mutation_p.R163Q	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	163	Lotus/OST-HTH 2.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						AGATTTGGACGATCATTCCAA	0.408000													8	123					0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41033329	41033329	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41033329C>T	ENST00000380620.3	+	5	1435	c.843C>T	c.(841-843)atC>atT	p.I281I	B3GALT5_ENST00000398714.2_Silent_p.I281I|B3GALT5_ENST00000380618.1_Silent_p.I281I|AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000343118.4_Silent_p.I281I			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	281					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				TCAGGAGGATCGTGGCCTGCC	0.577000													27	65					0	0	1	0	0
IGKV6D-41	28869	broad.mit.edu	37	2	90108537	90108537	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90108537C>T	ENST00000390271.2	+	0	34																											GAGATGGTGTCCCCGTTGCAA	0.408000													22	67					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	198051774	198051774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:198051774G>A	ENST00000328737.2	-	2	85	c.9C>T	c.(7-9)atC>atT	p.I3I	ANKRD44_ENST00000409919.1_Silent_p.I28I|ANKRD44_ENST00000539527.1_5'UTR|ANKRD44_ENST00000450567.1_Silent_p.I3I|ANKRD44_ENST00000282272.8_Silent_p.I20I|ANKRD44_ENST00000409153.1_Silent_p.I28I			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	28							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CAGTTTTATGGATGAGCATCC	0.428000													74	162					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	170020883	170020883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170020883C>T	ENST00000295797.4	+	18	2064	c.1759C>T	c.(1759-1761)Cct>Tct	p.P587S		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	587	AGC-kinase C-terminal.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GTATATCAATCCTCTTTTGAT	0.333000													33	81					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56524877	56524877	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56524877C>T	ENST00000394048.5	+	4	885	c.621C>T	c.(619-621)atC>atT	p.I207I	ESYT1_ENST00000541590.1_Silent_p.I207I|ESYT1_ENST00000267113.4_Silent_p.I207I	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	207						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						AAGAGCAGATCCTGCTGGACT	0.517000													5	51					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934929	28934929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28934929G>A	ENST00000257192.4	+	15	2982	c.2770G>A	c.(2770-2772)Gaa>Aaa	p.E924K	DSG1_ENST00000462981.2_Missense_Mutation_p.E283K|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	924					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GGTAGTGACAGAAAGAGTAAT	0.453000													48	185					0	0	1	0	0
PPP1R11	6992	broad.mit.edu	37	6	30037021	30037021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30037021C>T	ENST00000376772.3	+	3	642	c.319C>T	c.(319-321)Ccc>Tcc	p.P107S	PPP1R11_ENST00000376758.1_Missense_Mutation_p.P55S|PPP1R11_ENST00000376765.2_Missense_Mutation_p.P55S|PPP1R11_ENST00000376773.1_Missense_Mutation_p.P55S|PPP1R11_ENST00000376763.1_Missense_Mutation_p.P55S|PPP1R11_ENST00000376769.2_Missense_Mutation_p.P55S	NM_021959.2	NP_068778.1	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 11	107	Pro-rich.					soluble fraction	protein binding|protein phosphatase inhibitor activity			lung(2)|ovary(1)|prostate(1)|skin(2)	6						AGGACCGACCCCCACCACCCC	0.617000													68	125					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222216	140222216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140222216C>T	ENST00000531613.1	+	1	1310	c.1310C>T	c.(1309-1311)gCc>gTc	p.A437V	PCDHA8_ENST00000378123.3_Missense_Mutation_p.A437V|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGCTGTGGGCCACCGCCAGC	0.652000													31	33					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21268095	21268095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21268095G>A	ENST00000602326.1	-	12	1985	c.1402C>T	c.(1402-1404)Ctt>Ttt	p.L468F	EIF4G3_ENST00000544689.1_5'UTR|EIF4G3_ENST00000536266.1_Missense_Mutation_p.L66F|EIF4G3_ENST00000374937.3_Missense_Mutation_p.L468F|EIF4G3_ENST00000356916.3_Missense_Mutation_p.L473F|EIF4G3_ENST00000264211.8_Missense_Mutation_p.L462F|EIF4G3_ENST00000374935.3_Intron|EIF4G3_ENST00000374927.4_Missense_Mutation_p.L462F|EIF4G3_ENST00000400422.1_Missense_Mutation_p.L462F	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	462					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCTTCACTAAGGCAAGTTCTT	0.438000													65	230					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909381	123909381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123909381C>T	ENST00000330487.5	-	1	336	c.328G>A	c.(328-330)Gag>Aag	p.E110K		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E110*(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGGAAACACTCGGTGCTCCCC	0.552000													53	81					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185232257	185232257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185232257C>T	ENST00000296252.4	-	8	1176	c.1035G>A	c.(1033-1035)ggG>ggA	p.G345G	LIPH_ENST00000424591.2_Silent_p.G311G	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	345					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TGGTAATGTCCCCTCTTCTTA	0.378000													26	86					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50501529	50501529	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50501529C>T	ENST00000301149.3	+	6	1024	c.792C>T	c.(790-792)acC>acT	p.T264T	GPD1_ENST00000548814.1_Silent_p.T241T|GPD1_ENST00000547190.1_Intron	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	264					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	TGATCACTACCTGCTATGGAG	0.592000													17	171					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201023684	201023684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201023684G>A	ENST00000362061.3	-	29	3841	c.3615C>T	c.(3613-3615)ttC>ttT	p.F1205F	CACNA1S_ENST00000367338.3_Intron	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1205					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGGAGGCCAGGAAAGTCTGTG	0.597000													5	22					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241535813	241535813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241535813C>T	ENST00000391984.2	+	8	1552	c.1356C>T	c.(1354-1356)gaC>gaT	p.D452D	CAPN10_ENST00000354082.4_Intron|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000404753.3_Silent_p.D452D	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	452	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		ATGCATACGACCGGGAGGTCC	0.652000													13	86					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	95001514	95001514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:95001514G>A	ENST00000265627.5	-	4	348	c.338C>T	c.(337-339)cCa>cTa	p.P113L	PON3_ENST00000427422.1_Missense_Mutation_p.P113L|PON1_ENST00000542556.1_Intron	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			GATCCCATGTGGATTAAATAA	0.393000													35	93					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10419245	10419245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10419245G>A	ENST00000226207.5	-	5	597	c.503C>T	c.(502-504)aCt>aTt	p.T168I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	168	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CCACTCACCAGTCAGCATGAA	0.423000													73	92					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78322274	78322274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78322274C>T	ENST00000255189.3	-	13	2191	c.2163G>A	c.(2161-2163)gaG>gaA	p.E721E	DMGDH_ENST00000540686.1_Silent_p.E341E|DMGDH_ENST00000380311.4_Silent_p.E520E	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	721					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TGAAGGCTTTCTCCAGGCGTA	0.423000													65	142					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263760	39263760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39263760C>T	ENST00000280481.7	+	1	2495	c.2279C>T	c.(2278-2280)aCc>aTc	p.T760I		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	760					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCACTGGGTACCTTGGTCTTG	0.527000													21	69					0	0	1	0	0
GOT1	2805	broad.mit.edu	37	10	101180539	101180539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101180539G>A	ENST00000370508.5	-	2	169	c.142C>T	c.(142-144)Ccc>Tcc	p.P48S	GOT1_ENST00000543866.1_Missense_Mutation_p.P27S|GOT1_ENST00000471741.1_5'UTR	NM_002079.2	NP_002070.1	P17174	AATC_HUMAN	glutamic-oxaloacetic transaminase 1, soluble	48					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)	16		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAAACCCAGGGATGGCAGTCA	0.473000													28	117					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182026917	182026917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:182026917C>T	ENST00000339948.3	-	2	436	c.229G>A	c.(229-231)Gag>Aag	p.E77K		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						TTCTCTTCCTCTTTGCCCAGT	0.557000													19	53					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101188637	101188637	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101188637G>A	ENST00000313669.7	+	0	914				COL26A1_ENST00000397927.3_RNA|COL26A1_ENST00000528707.1_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		GGGCCTCCAGGGCCCCGTGGG	0.687000													15	19					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11780534	11780534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11780534C>T	ENST00000381486.2	+	33	6104	c.5804C>T	c.(5803-5805)gCc>gTc	p.A1935V	GREB1_ENST00000396123.1_Missense_Mutation_p.A933V|GREB1_ENST00000234142.5_Missense_Mutation_p.A1935V	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1935						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACCGCCAATGCCAGGGAAGAC	0.602000													21	126					0	0	1	0	0
NNMT	4837	broad.mit.edu	37	11	114167333	114167333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:114167333G>A	ENST00000535401.1	+	3	319	c.55G>A	c.(55-57)Gat>Aat	p.D19N	NNMT_ENST00000299964.3_Missense_Mutation_p.D19N|RP11-64D24.2_ENST00000544925.1_RNA			P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	19					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	TAACCCTCGGGATTACCTAGA	0.428000													33	74					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169183279	169183279	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169183279C>T	ENST00000393743.3	-	24	3436	c.3144_splice	c.e24-1	p.E1049_splice	DDX60_ENST00000505393.1_5'UTR	NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1049							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		GGGCACAGTTCCTTGAAAACA	0.308000													18	43					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101739420	101739420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101739420C>T	ENST00000261637.4	+	37	4868	c.4694C>T	c.(4693-4695)aCt>aTt	p.T1565I		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1565					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GTACAACTTACTCATTACCAT	0.358000													23	87					0	0	1	0	0
ISX	91464	broad.mit.edu	37	22	35478537	35478537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:35478537C>T	ENST00000308700.6	+	2	1208	c.256C>T	c.(256-258)Cgt>Tgt	p.R86C	ISX_ENST00000404699.2_Missense_Mutation_p.R86C	NM_001008494.1	NP_001008494.1	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	86						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R86C(2)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(12)|ovary(3)|prostate(1)|skin(4)	26						GCGGAGGGTTCGTACCACCTT	0.557000													35	101					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301421	11301421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11301421C>T	ENST00000397056.1	+	3	889	c.698C>T	c.(697-699)tCc>tTc	p.S233F	HRH1_ENST00000431010.2_Missense_Mutation_p.S233F|HRH1_ENST00000438284.2_Missense_Mutation_p.S233F	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	233					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TCCCTCCCTTCCTTCTCAGAA	0.532000													10	62					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26747146	26747146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26747146C>T	ENST00000529632.2	+	12	2732	c.2536C>T	c.(2536-2538)Ctg>Ttg	p.L846L	SEZ6L_ENST00000411842.2_Silent_p.L43L|SEZ6L_ENST00000343706.4_Silent_p.L846L|SEZ6L_ENST00000360929.3_Intron|SEZ6L_ENST00000404234.3_Silent_p.L846L|SEZ6L_ENST00000248933.6_Silent_p.L846L|SEZ6L_ENST00000402979.1_Silent_p.L619L|SEZ6L_ENST00000403121.1_Silent_p.L619L	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	846	Sushi 4.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GAGTTCTCTTCTGACCTGCTA	0.552000													39	77					0	0	1	0	0
UGT2A2	574537	broad.mit.edu	37	4	70505136	70505136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70505136C>T	ENST00000457664.2	-	1	222	c.223G>A	c.(223-225)Gat>Aat	p.D75N	UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000514019.1_Missense_Mutation_p.D276N|UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000503640.1_Intron	NM_001105677.2	NP_001099147.2																					ACAGGAGAATCGGGATTGGAG	0.353000													41	83					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113276350	113276350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113276350G>A	ENST00000401783.2	-	4	1337	c.1001C>T	c.(1000-1002)cCa>cTa	p.P334L	SVEP1_ENST00000374469.1_Missense_Mutation_p.P311L|SVEP1_ENST00000374461.1_Missense_Mutation_p.P311L|SVEP1_ENST00000302728.8_Missense_Mutation_p.P334L|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	334					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GATTCCTCCTGGTGAGCCTTC	0.512000													7	9					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699765	48699765	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48699765G>A	ENST00000544264.1	-	1	583	c.303C>T	c.(301-303)ccC>ccT	p.P101P	CELSR3_ENST00000164024.4_Silent_p.P101P			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	101					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTGCTCAGGGGGCCCTCGAC	0.657000													63	161					0	0	1	0	0
PARK7	11315	broad.mit.edu	37	1	8025434	8025434	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8025434C>T	ENST00000493678.1	+	3	208	c.141C>T	c.(139-141)agC>agT	p.S47S	PARK7_ENST00000377488.1_Silent_p.S47S|PARK7_ENST00000377491.1_Silent_p.S47S|PARK7_ENST00000497113.1_3'UTR|PARK7_ENST00000338639.5_Silent_p.S47S|PARK7_ENST00000377493.5_Silent_p.S47S			Q99497	PARK7_HUMAN	parkinson protein 7	47					autophagy|cell death|cellular response to hydrogen peroxide|inflammatory response|mitochondrion organization|negative regulation of cell death|negative regulation of protein binding|neuroprotection|protein stabilization|regulation of androgen receptor signaling pathway|regulation of inflammatory response|single fertilization	mitochondrion|nucleus	mRNA binding|peptidase activity|peroxidase activity|protein homodimerization activity			large_intestine(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;1.28e-70)|GBM - Glioblastoma multiforme(8;3.05e-36)|Colorectal(212;6.83e-08)|COAD - Colon adenocarcinoma(227;7.51e-06)|Kidney(185;5.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000414)|KIRC - Kidney renal clear cell carcinoma(229;0.000967)|STAD - Stomach adenocarcinoma(132;0.00102)|READ - Rectum adenocarcinoma(331;0.0649)		TACAGTGTAGCCGTGATGTGG	0.403000													29	55					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44691437	44691437	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44691437G>A	ENST00000290231.6	-	8	1406	c.1242C>T	c.(1240-1242)ctC>ctT	p.L414L		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				TAGCAGAGGGGAGCACTTGGC	0.617000													44	110					0	0	1	0	0
IGLV4-69	28784	broad.mit.edu	37	22	22385778	22385778	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22385778C>T	ENST00000390282.2	+	0	327				PRAMEF24P_ENST00000337471.4_RNA																							TCTCAGGCTCCAGCTCTGGGG	0.577000													27	65					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39805130	39805130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39805130C>T	ENST00000248668.4	-	1	846	c.847G>A	c.(847-849)Gac>Aac	p.D283N		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	283	LRRCT.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AAGTAGCGGTCGGTGAGGTGT	0.701000													3	27					0	0	1	0	0
GPR1	2825	broad.mit.edu	37	2	207041526	207041526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207041526C>T	ENST00000407325.2	-	3	808	c.446G>A	c.(445-447)cGa>cAa	p.R149Q	GPR1_ENST00000437420.1_Missense_Mutation_p.R149Q	NM_001098199.1|NM_001261452.1|NM_001261453.1|NM_001261454.1|NM_001261455.1|NM_005279.3	NP_001091669.1|NP_001248381.1|NP_001248382.1|NP_001248383.1|NP_001248384.1|NP_005270.2	P46091	GPR1_HUMAN	G protein-coupled receptor 1	149						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	18		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		CTTGAGGGTTCGATGCCGATG	0.463000													35	86					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109182393	109182393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109182393G>A	ENST00000326495.5	-	15	2614	c.2521C>T	c.(2521-2523)Cct>Tct	p.P841S	SSH1_ENST00000360239.3_Missense_Mutation_p.P529S	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	841					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTGGAGGGAGGTGCTGGGTCT	0.657000													24	35					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476416	57476416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57476416G>A	ENST00000371236.2	-	14	1883	c.1620C>T	c.(1618-1620)ccC>ccT	p.P540P	DAB1_ENST00000371231.1_Silent_p.P573P|DAB1_ENST00000439789.2_Silent_p.P454P|DAB1_ENST00000371234.4_Silent_p.P540P|DAB1_ENST00000420954.2_Silent_p.P538P|DAB1_ENST00000414851.2_Silent_p.P522P|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	573					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GCTCCCCACTGGGCTCACCAA	0.443000													38	98					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2336706	2336706	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2336706G>A	ENST00000301732.5	-	22	3967	c.3267C>T	c.(3265-3267)gaC>gaT	p.D1089D	ABCA3_ENST00000382381.3_Silent_p.D1031D	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	1089					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				CGTTAAACTGGTCCTTGGCAG	0.632000													16	55					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45444226	45444226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45444226G>A	ENST00000321429.4	+	25	3576	c.3169G>A	c.(3169-3171)Ggg>Agg	p.G1057R	DUOX1_ENST00000389037.3_Missense_Mutation_p.G1057R|DUOX1_ENST00000561166.1_Missense_Mutation_p.G703R	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	1057	Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CATCGCTGGGGGGCTTTTCCT	0.602000													9	29					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51170907	51170907	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51170907G>A	ENST00000293441.1	-	22	4328	c.4310C>T	c.(4309-4311)cCg>cTg	p.P1437L	SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000391813.1_Missense_Mutation_p.P824L|SHANK1_ENST00000359082.3_Missense_Mutation_p.P1428L|SHANK1_ENST00000391814.1_Missense_Mutation_p.P1445L	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1437					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGCGGCGGGCGGGCTGGCGGG	0.796000													4	2					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95764944	95764944	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:95764944G>A	ENST00000311106.3	-	2	495	c.258C>T	c.(256-258)atC>atT	p.I86I	PCSK1_ENST00000508626.1_Silent_p.I39I|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	86					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCTCTTAGTGATATGAAAGG	0.318000													29	61					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118375153	118375153	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118375153C>A	ENST00000534358.1	+	27	8569	c.8546C>A	c.(8545-8547)cCt>cAt	p.P2849H	KMT2A_ENST00000389506.5_Missense_Mutation_p.P2846H|KMT2A_ENST00000354520.4_Missense_Mutation_p.P2808H	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AATATCCTGCCTTCAGACATT	0.428000													46	150					1.06522e-23	1.07221e-23	1	1	0
TBP	6908	broad.mit.edu	37	6	170873696	170873696	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:170873696C>T	ENST00000392092.2	+	4	840	c.561C>T	c.(559-561)gcC>gcT	p.A187A	TBP_ENST00000230354.6_Silent_p.A187A|TBP_ENST00000540980.1_Silent_p.A167A	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	187				A -> R (in Ref. 3; AAC03409).	cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		CACTTCGTGCCCGAAACGCCG	0.318000													17	26					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2444192	2444192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2444192C>T	ENST00000452833.1	-	1	83	c.75G>A	c.(73-75)agG>agA	p.R25R	TRPM5_ENST00000528453.1_Silent_p.R25R|TRPM5_ENST00000155858.6_Silent_p.R25R|TRPM5_ENST00000533060.1_Silent_p.R25R			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	25						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGACCTCGCCCCTGTGCAAGC	0.652000													7	66					0	0	1	0	0
CCKAR	886	broad.mit.edu	37	4	26484791	26484791	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:26484791C>T	ENST00000295589.3	-	4	935	c.741G>A	c.(739-741)aaG>aaA	p.K247K		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	247					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	TAGCAGACTTCTTCTGGCTAG	0.373000													53	140					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49031038	49031038	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:49031038G>A	ENST00000380950.2	-	27	4728	c.4541C>T	c.(4540-4542)cCt>cTt	p.P1514L	CEP152_ENST00000399334.3_Missense_Mutation_p.P1458L	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	1458					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TGATTCAGAAGGACCAGGGGT	0.398000													26	66					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3157830	3157830	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3157830G>A	ENST00000262958.3	+	6	1107	c.849G>A	c.(847-849)gaG>gaA	p.E283E		NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	283					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		ACATCCTGGAGGAGAAAATCC	0.488000													72	163					0	0	1	0	0
EMILIN1	11117	broad.mit.edu	37	2	27302010	27302010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27302010C>T	ENST00000380320.4	+	1	576	c.77C>T	c.(76-78)cCt>cTt	p.P26L		NM_007046.3	NP_008977.1	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1	26					cell adhesion	collagen				breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(14)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	26	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCTACCCTCCTCGAGGTTTC	0.716000													12	25					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39893908	39893908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:39893908C>T	ENST00000564288.1	+	63	17529	c.16752C>T	c.(16750-16752)ttC>ttT	p.F5584F	MACF1_ENST00000289893.4_Silent_p.F4024F|MACF1_ENST00000567887.1_Silent_p.F5621F|MACF1_ENST00000361689.2_Silent_p.F3522F|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000372915.3_Intron|MACF1_ENST00000317713.7_Silent_p.F3522F|MACF1_ENST00000545844.1_Silent_p.F3522F			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5589					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTTCAGTGTTCGTAAAGGATT	0.448000													13	33					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14841576	14841576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14841576G>A	ENST00000380881.4	-	11	2568	c.1753C>T	c.(1753-1755)Cat>Tat	p.H585Y	FREM1_ENST00000422223.2_Missense_Mutation_p.H584Y|FREM1_ENST00000380880.3_Missense_Mutation_p.H584Y			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	584					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGGAAGCCATGGACAGGATAG	0.368000													51	94					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119770494	119770494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119770494C>T	ENST00000313400.4	-	7	1568	c.1468G>A	c.(1468-1470)Gac>Aac	p.D490N	ASTN2_ENST00000361209.2_Missense_Mutation_p.D439N|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.D490N			O75129	ASTN2_HUMAN	astrotactin 2	490						integral to membrane		p.D439N(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TTTAACCAGTCGGAGATGTCC	0.507000													15	50					0	0	1	0	0
IPO8	10526	broad.mit.edu	37	12	30790020	30790020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:30790020G>A	ENST00000256079.4	-	22	2929	c.2591C>T	c.(2590-2592)tCa>tTa	p.S864L	IPO8_ENST00000544829.1_Missense_Mutation_p.S659L	NM_006390.3	NP_006381.2	O15397	IPO8_HUMAN	importin 8	864					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(16)|liver(1)|lung(22)|prostate(2)|skin(2)|urinary_tract(2)	52	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GAAAAGAATTGAGGGAACAAT	0.438000													47	92					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72063173	72063173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:72063173G>A	ENST00000305425.4	-	7	2106	c.1684C>T	c.(1684-1686)Cct>Tct	p.P562S	DACH1_ENST00000359684.2_Missense_Mutation_p.P614S|DACH1_ENST00000354591.4_Missense_Mutation_p.P360S|DACH1_ENST00000313174.7_Missense_Mutation_p.P414S	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	612					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGTCCATCAGGAAACAGAAAA	0.463000													47	165					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90433300	90433300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:90433300G>A	ENST00000369393.3	-	39	5824	c.5709C>T	c.(5707-5709)ttC>ttT	p.F1903F	MDN1_ENST00000428876.1_Silent_p.F1903F			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1903					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TACTGGCAATGAACTCCATGT	0.333000													12	30					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205033876	205033876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205033876G>A	ENST00000331830.4	+	12	1801	c.1517G>A	c.(1516-1518)cGa>cAa	p.R506Q		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	506					axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTATCTGTGCGAGGTGAGGGC	0.537000													42	98					0	0	1	0	0
KLF14	136259	broad.mit.edu	37	7	130418345	130418345	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:130418345C>T	ENST00000310992.4	-	1	543	c.516G>A	c.(514-516)ggG>ggA	p.G172G		NM_138693.2	NP_619638.1	Q8TD94	KLF14_HUMAN	Kruppel-like factor 14	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Melanoma(18;0.0435)					CGGGGCCTGCCCCTAGGGCCC	0.741000													3	13					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284753	52284753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52284753C>T	ENST00000301190.6	+	5	1250	c.1023C>T	c.(1021-1023)tcC>tcT	p.S341S	ANKRD33_ENST00000538991.1_Silent_p.S147S|ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Silent_p.S216S	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	216								p.S341S(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GAAGCAAGTCCGTGCCAGAGC	0.657000													10	27					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100376662	100376662	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100376662C>T	ENST00000262233.6	+	12	1462	c.1323C>T	c.(1321-1323)atC>atT	p.I441I	EML1_ENST00000334192.4_Silent_p.I460I|EML1_ENST00000327921.9_Silent_p.I429I	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	441						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				GTGGCAACATCTTAGTATGGG	0.358000													23	60					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369443	56369443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56369443C>T	ENST00000301295.6	+	3	1106	c.684C>T	c.(682-684)ttC>ttT	p.F228F	NLRP4_ENST00000346986.5_Silent_p.F228F|NLRP4_ENST00000587891.1_Silent_p.F153F	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	228	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GACTCTTGTTCGTCATCGACA	0.552000													33	81					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128496919	128496919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128496919C>T	ENST00000325888.8	+	45	7766	c.7505C>T	c.(7504-7506)gCt>gTt	p.A2502V	FLNC_ENST00000346177.6_Missense_Mutation_p.A2469V|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2502	Interaction with INPPL1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CAGAGCCAGGCTGGGGACCCA	0.627000													8	43					0	0	1	0	0
RP11-64J4.2	0	broad.mit.edu	37	17	3214646	3214646	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3214646C>T	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							TAGCCATGGCCTATGACCGCT	0.567000													22	35					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21721262	21721262	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21721262C>T	ENST00000328843.6	+	31	5473	c.5442C>T	c.(5440-5442)gcC>gcT	p.A1814A	DNAH11_ENST00000409508.3_Silent_p.A1809A			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1814	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATGTCCATGCCAGAGACGTGG	0.388000									Kartagener syndrome				28	78					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439799	52439799	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52439799A>G	ENST00000242819.4	+	2	581	c.285A>G	c.(283-285)gaA>gaG	p.E95E		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	95						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CTTTCTGGGAAGAGGAGAAAA	0.468000													13	101					0	0	1	0	0
CCKBR	887	broad.mit.edu	37	11	6292205	6292205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6292205C>T	ENST00000525462.1	+	4	986	c.983C>T	c.(982-984)tCg>tTg	p.S328L	CCKBR_ENST00000334619.2_Intron|CCKBR_ENST00000532396.1_Intron|CCKBR_ENST00000532715.1_Intron			P32239	GASR_HUMAN	cholecystokinin B receptor	269					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TGGGGGGACTCGCCTTTTTCT	0.622000													14	34					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784504	82784504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82784504C>T	ENST00000423517.2	-	2	1790	c.1453G>A	c.(1453-1455)Ggc>Agc	p.G485S	PCLO_ENST00000333891.8_Missense_Mutation_p.G485S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	435	10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.|Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTGCTGGGCCAGGCTGTTGA	0.607000													40	106					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72992819	72992819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72992819G>A	ENST00000268489.5	-	2	1898	c.1226C>T	c.(1225-1227)tCg>tTg	p.S409L	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	409					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CTTCAGTACCGAGCTGGTGAG	0.657000													20	147					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36069802	36069802	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36069802G>A	ENST00000303965.4	-	33	5331	c.4842C>T	c.(4840-4842)caC>caT	p.H1614H		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1614					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						GCTCCAGGCAGTGGGCCACCA	0.522000													27	135					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75866417	75866417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75866417C>T	ENST00000274364.6	+	4	613	c.316C>T	c.(316-318)Cat>Tat	p.H106Y	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	106	CH.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GTCTGGCCTTCATTTTCGACA	0.433000													25	78					0	0	1	0	0
FAM83E	54854	broad.mit.edu	37	19	49107064	49107064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49107064G>A	ENST00000263266.3	-	4	1052	c.863C>T	c.(862-864)tCc>tTc	p.S288F		NM_017708.3	NP_060178.2	Q2M2I3	FA83E_HUMAN	family with sequence similarity 83, member E	288										NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GAGCGGGCAGGAGGCCGCGTA	0.701000													13	31					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103498964	103498964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:103498964C>T	ENST00000372588.4	-	2	460	c.377G>A	c.(376-378)gGg>gAg	p.G126E		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	126					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						GGTTTGTGGCCCCTCCGCCGG	0.662000													8	41					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41900474	41900474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41900474C>T	ENST00000298919.7	+	4	668	c.280C>T	c.(280-282)Cct>Tct	p.P94S	PDZRN4_ENST00000402685.2_Missense_Mutation_p.P354S|PDZRN4_ENST00000539469.2_Missense_Mutation_p.P96S			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	354							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCCACCTACCCCTCCAGTGCC	0.483000													16	89					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152383234	152383234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152383234C>T	ENST00000271835.3	-	3	386	c.324G>A	c.(322-324)ggG>ggA	p.G108G	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	108					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGCGAGGCCCCAGAGTGGA	0.592000													108	322					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4281435	4281435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4281435C>T	ENST00000404826.2	+	43	6280	c.6141C>T	c.(6139-6141)atC>atT	p.I2047I	SDK1_ENST00000389531.3_Silent_p.I2027I|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2047					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GAAAGGGGATCTCCACCATGG	0.602000													10	30					0	0	1	0	0
CDKL3	51265	broad.mit.edu	37	5	133634402	133634402	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:133634402C>T	ENST00000265334.4	-	13	1838		c.e13-1		CDKL3_ENST00000435240.2_Intron|CDKL3_ENST00000523054.1_Splice_Site|CDKL3_ENST00000536186.1_Intron|CDKL3_ENST00000518409.1_Intron	NM_001113575.1	NP_001107047.1	Q8IVW4	CDKL3_HUMAN	cyclin-dependent kinase-like 3							cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(3)	11			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATCTCCACCCTAAAATTAGA	0.333000													48	125					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54963357	54963357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54963357C>T	ENST00000326764.5	+	3	605	c.126C>T	c.(124-126)gcC>gcT	p.A42A	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	42							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GGGAGAAGGCCCGTCAGGCCC	0.637000													26	79					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72360605	72360605	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72360605G>A	ENST00000441259.1	-	2	214	c.54C>T	c.(52-54)ccC>ccT	p.P18P	PRF1_ENST00000373209.2_Silent_p.P18P	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	18					apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						GGGCAGGGACGGGCAGGGGCA	0.677000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				5	18					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49166321	49166321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49166321G>A	ENST00000307885.4	-	16	3321	c.2627C>T	c.(2626-2628)tCt>tTt	p.S876F	ADCY6_ENST00000357869.3_Missense_Mutation_p.S823F|ADCY6_ENST00000550422.1_Missense_Mutation_p.S823F	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	876					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CTCATTGGAAGAAGCCCTGGT	0.512000													8	42					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354218	57354218	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57354218G>A	ENST00000314922.3	-	2	493	c.417C>T	c.(415-417)ttC>ttT	p.F139F	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Silent_p.F139F	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	139					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CCTTCTTCATGAAGCCCCCAT	0.532000													21	105					0	0	1	0	0
C17orf59	54785	broad.mit.edu	37	17	8092541	8092541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8092541G>A	ENST00000389017.4	-	1	1023	c.918C>T	c.(916-918)tcC>tcT	p.S306S		NM_017622.2	NP_060092.2	Q96GS4	CQ059_HUMAN	chromosome 17 open reading frame 59	306										large_intestine(2)|lung(3)|urinary_tract(1)	6						CTTCACCTAAGGAGTCCACAG	0.677000													23	51					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87730951	87730951	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:87730951G>A	ENST00000436978.1	+	46	7608	c.7128G>A	c.(7126-7128)ctG>ctA	p.L2376L	PTPN13_ENST00000316707.6_Silent_p.L2180L|PTPN13_ENST00000411767.2_Silent_p.L2371L|PTPN13_ENST00000511467.1_Silent_p.L2376L|PTPN13_ENST00000427191.2_Silent_p.L2352L	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2371	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TTTCTCATCTGAATTTCACTG	0.388000													38	84					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40114687	40114687	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40114687G>A	ENST00000324616.5	+	13	1747	c.1593G>A	c.(1591-1593)agG>agA	p.R531R		NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	531										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						ATGTAGAAAGGATGGCAAAAC	0.318000													25	78					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51379771	51379771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51379771G>A	ENST00000216392.7	-	13	1928	c.1596C>T	c.(1594-1596)ctC>ctT	p.L532L	RP11-218E20.5_ENST00000557343.1_RNA|PYGL_ENST00000532462.1_Silent_p.L532L|PYGL_ENST00000544180.2_Silent_p.L498L	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	532					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CGAGTTCCCGGAGGAAGACAT	0.478000													19	43					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11765357	11765357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11765357C>T	ENST00000381486.2	+	24	4525	c.4225C>T	c.(4225-4227)Ccc>Tcc	p.P1409S	GREB1_ENST00000396123.1_Missense_Mutation_p.P407S|GREB1_ENST00000234142.5_Missense_Mutation_p.P1409S	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1409						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CAAGAAGTTGCCCTTTGACTA	0.463000													104	262					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860201	16860201	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16860201T>C	ENST00000524140.2	+	6	1166	c.748T>C	c.(748-750)Ttg>Ctg	p.L250L	NWD1_ENST00000523826.1_Silent_p.L44L|NWD1_ENST00000379808.3_Silent_p.L250L|NWD1_ENST00000339803.6_Silent_p.L115L|NWD1_ENST00000552788.1_Silent_p.L250L|NWD1_ENST00000549814.1_Silent_p.L250L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	250							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAGCCGCGACTTGGTGAACCC	0.597000													21	47					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119451284	119451284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119451284G>A	ENST00000273390.5	+	9	1239	c.1162G>A	c.(1162-1164)Gac>Aac	p.D388N		NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		CAACTCAGAGGACTTTGTAGT	0.358000													15	42					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145895603	145895603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145895603C>T	ENST00000311104.2	-	1	150	c.74G>A	c.(73-75)gGa>gAa	p.G25E		NM_194251.2	NP_919227.2	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	25						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGGTACCCTCCGGCAAAGTG	0.542000													14	150					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65260194	65260194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65260194C>T	ENST00000389722.3	-	13	2240	c.2187G>A	c.(2185-2187)aaG>aaA	p.K729K	SPTB_ENST00000389720.3_Silent_p.K729K|SPTB_ENST00000389721.5_Silent_p.K729K|SPTB_ENST00000556626.1_Silent_p.K729K|SPTB_ENST00000542895.1_Silent_p.K729K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	729					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CAGCCAGGTCCTTCAGCTGGT	0.592000													14	40					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9225293	9225293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9225293C>T	ENST00000318602.7	-	30	4238	c.3931G>A	c.(3931-3933)Gaa>Aaa	p.E1311K		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	1311					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	ATGCTGTATTCCCCAGGCAGC	0.517000													62	121					0	0	1	0	0
TTC30A	92104	broad.mit.edu	37	2	178482356	178482356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:178482356G>A	ENST00000355689.4	-	1	1338	c.1074C>T	c.(1072-1074)ctC>ctT	p.L358L	AC073834.3_ENST00000357045.4_RNA	NM_152275.3	NP_689488.3	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	358					cell projection organization	cilium	binding	p.L358L(1)		autonomic_ganglia(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			AGAAGTCATAGAGATAGGGTG	0.473000													38	110					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214556972	214556972	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:214556972G>A	ENST00000366956.5	-	13	2420	c.2226C>T	c.(2224-2226)gcC>gcT	p.A742A	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	742					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TGGGGATGCGGGCCAGGGCCG	0.652000													21	47					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13715998	13715998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13715998C>T	ENST00000279593.3	-	13	4383	c.4174G>A	c.(4174-4176)Ggg>Agg	p.G1392R		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1392					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGTCGTCCCCAAAAGTGGGG	0.622000													13	30					0	0	1	0	0
OR7D2	162998	broad.mit.edu	37	19	9296535	9296535	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9296535C>T	ENST00000344248.2	+	1	257	c.78C>T	c.(76-78)ttC>ttT	p.F26F		NM_175883.2	NP_787079.1	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D, member 2	26					regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F26L(1)		breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	20						TACAGCCGTTCATATTTGGGC	0.493000													29	54					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401535	77401535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77401535G>A	ENST00000282849.5	-	4	999	c.581C>T	c.(580-582)cCt>cTt	p.P194L	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	194					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GTGACCCGCAGGGGAGCTGTA	0.507000													30	58					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18044404	18044404	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18044404G>A	ENST00000205890.5	+	22	5816	c.5478G>A	c.(5476-5478)agG>agA	p.R1826R	MYO15A_ENST00000412324.1_3'UTR	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1826	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					AGACCGTGAGGATCCGCAAGG	0.552000											OREG0024223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	16					0	0	1	0	0
OGG1	4968	broad.mit.edu	37	3	9798279	9798279	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9798279C>A	ENST00000302036.7	+	5	1215	c.872C>A	c.(871-873)cCg>cAg	p.P291Q	OGG1_ENST00000344629.7_Missense_Mutation_p.P291Q|OGG1_ENST00000339511.5_Missense_Mutation_p.P291Q|OGG1_ENST00000302003.7_Missense_Mutation_p.P291Q|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Missense_Mutation_p.P291Q|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Missense_Mutation_p.P291Q	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	291					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					GCGAAGGGACCGAGCCCCCAG	0.602000								Base excision repair (BER), DNA glycosylases					18	47					1.00905e-13	1.01423e-13	1	1	0
SMPD3	55512	broad.mit.edu	37	16	68405281	68405281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68405281C>T	ENST00000219334.5	-	3	1407	c.804G>A	c.(802-804)agG>agA	p.R268R	SMPD3_ENST00000563226.1_Silent_p.R268R|SMPD3_ENST00000568373.1_Silent_p.R268R	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	268					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CAGCTCCGTTCCTGGCCTGGC	0.716000													14	22					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179545793	179545793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179545793G>A	ENST00000393371.2	-	8	1277	c.981C>T	c.(979-981)atC>atT	p.I327I	RASGEF1C_ENST00000522500.1_Silent_p.I176I|RASGEF1C_ENST00000361132.4_Silent_p.I327I			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	327	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTACCTCGAGGATGAAAAACT	0.607000													8	119					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115947732	115947732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115947732C>T	ENST00000251864.2	+	2	295	c.142C>T	c.(142-144)Cct>Tct	p.P48S	TDRD1_ENST00000369281.2_Missense_Mutation_p.P48S|TDRD1_ENST00000369282.1_Missense_Mutation_p.P48S|TDRD1_ENST00000369280.1_Missense_Mutation_p.P48S|TDRD1_ENST00000422662.1_5'UTR	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	48					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGGAACACTTCCTAACCACCC	0.373000													34	114					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20141139	20141139	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20141139G>A	ENST00000375121.2	-	1	632	c.456C>T	c.(454-456)gcC>gcT	p.A152A	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	152						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGCGCCGGGCTGCCACGT	0.607000													28	141					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439638	150439638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150439638C>T	ENST00000358647.3	+	3	778	c.411C>T	c.(409-411)gtC>gtT	p.V137V	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGAAAGAGGTCTTTGGGACAG	0.582000													34	100					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832027	61832027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61832027G>A	ENST00000280772.1	-	37	8803	c.8612C>T	c.(8611-8613)tCg>tTg	p.S2871L	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2871					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.S2871L(1)		NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AAGTACATGCGAAAGTTTTTC	0.398000													34	88					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4945269	4945269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4945269C>T	ENST00000345988.2	-	11	1324	c.1235G>A	c.(1234-1236)gGg>gAg	p.G412E	PPL_ENST00000590782.2_Missense_Mutation_p.G410E	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	412					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						CACCTGCTCCCCCTCAAAGTC	0.627000													15	46					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735093	41735093	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41735093C>T	ENST00000352645.4	+	9	971	c.714C>T	c.(712-714)gcC>gcT	p.A238A	ZC3H7B_ENST00000351589.4_Silent_p.A238A	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	254					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ACCTGCTGGCCCCCCTGGACA	0.667000													46	126					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168066390	168066390	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168066390C>T	ENST00000367838.1	-	5	768	c.455G>A	c.(454-456)tGg>tAg	p.W152*	GPR161_ENST00000367835.1_Nonsense_Mutation_p.W152*|GPR161_ENST00000271357.5_Nonsense_Mutation_p.W152*|GPR161_ENST00000546300.1_Nonsense_Mutation_p.W38*|GPR161_ENST00000367836.1_Nonsense_Mutation_p.W20*|GPR161_ENST00000537209.1_Nonsense_Mutation_p.W172*|GPR161_ENST00000361697.2_Nonsense_Mutation_p.W152*|GPR161_ENST00000539777.1_Nonsense_Mutation_p.W74*	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	152					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CGAGTGAAGCCAGATGTAGAC	0.552000													6	86					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62550251	62550251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62550251G>A	ENST00000371158.2	+	33	4422	c.4308G>A	c.(4306-4308)atG>atA	p.M1436I	INADL_ENST00000545929.1_Missense_Mutation_p.M109I|INADL_ENST00000543708.1_Missense_Mutation_p.M220I|INADL_ENST00000316485.6_Missense_Mutation_p.M1436I	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1436					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						GACAGGAAATGATTATAGAAA	0.468000													21	86					0	0	1	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737853	62737853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62737853G>A	ENST00000369768.1	-	1	671	c.332C>T	c.(331-333)cCc>cTc	p.P111L		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	111						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CTCCCCGAAGGGCCAGTACTG	0.607000													16	33					0	0	1	0	0
RAD51AP1	10635	broad.mit.edu	37	12	4662197	4662197	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4662197A>T	ENST00000228843.9	+	8	706	c.656A>T	c.(655-657)gAc>gTc	p.D219V	RAD51AP1_ENST00000544931.1_3'UTR|RAD51AP1_ENST00000544927.1_Missense_Mutation_p.D202V|RAD51AP1_ENST00000352618.4_Missense_Mutation_p.D202V|RAD51AP1_ENST00000321524.7_Missense_Mutation_p.D219V|RAD51AP1_ENST00000543041.1_Missense_Mutation_p.D84V	NM_001130862.1	NP_001124334.1	Q96B01	R51A1_HUMAN	RAD51 associated protein 1	219					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|RNA binding|single-stranded DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			GAGGATAATGACGAAGACTTC	0.318000													10	37					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168901	142168901	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142168901G>A	ENST00000454561.2	-	0	144																											TCCTGGGGAAGAGCCGAGTGA	0.592000													12	20					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10541625	10541625	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10541625C>A	ENST00000293683.5	+	1	105	c.105C>A	c.(103-105)gcC>gcA	p.A35A	PDE4A_ENST00000592685.1_Intron|PDE4A_ENST00000352831.6_Intron|PDE4A_ENST00000380702.2_Intron	NM_001111308.1	NP_001104778.1	P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	305					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	agcccctggccccgcgcgcgc	0.761000													3	6					0.004672	0.00467489	1	1	0
ZNF699	374879	broad.mit.edu	37	19	9408050	9408050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9408050G>A	ENST00000591998.1	-	5	620	c.392C>T	c.(391-393)tCc>tTc	p.S131F	ZNF699_ENST00000308650.3_Missense_Mutation_p.S131F			Q32M78	ZN699_HUMAN	zinc finger protein 699	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S131F(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GGAGAACCAGGAATCATTCCT	0.363000													34	45					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19339087	19339087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19339087C>T	ENST00000252575.5	+	8	2701	c.2658C>T	c.(2656-2658)gcC>gcT	p.A886A	NCAN_ENST00000538881.1_Silent_p.A337A	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	886					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GAGTTCCAGCCATGTCTACAC	0.602000													32	98					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46094342	46094342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46094342C>T	ENST00000323040.4	-	2	1727	c.783G>A	c.(781-783)gaG>gaA	p.E261E	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	261						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		AGACGCGCTCCTCGAAGCCGC	0.637000													8	57					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132445295	132445295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:132445295C>T	ENST00000333577.4	+	2	240	c.131C>T	c.(130-132)cCc>cTc	p.P44L	EP400_ENST00000332482.4_Missense_Mutation_p.P44L|EP400_ENST00000389562.2_Missense_Mutation_p.P44L|EP400_ENST00000389561.2_Missense_Mutation_p.P44L|EP400_ENST00000330386.6_Missense_Mutation_p.P44L			Q96L91	EP400_HUMAN	E1A binding protein p400	44					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCCTTCGCTCCCTCAGCAAGC	0.652000													24	30					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299405	58299405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58299405G>A	ENST00000377918.3	+	4	3483	c.3457G>A	c.(3457-3459)Gac>Aac	p.D1153N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1153					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCGGGGAAACGACCCTGTGGC	0.448000													38	119					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101051255	101051255	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101051255C>T	ENST00000360863.6	-	14	2264	c.2070G>A	c.(2068-2070)tgG>tgA	p.W690*	RGS22_ENST00000523437.1_Nonsense_Mutation_p.W678*|RGS22_ENST00000523287.1_Nonsense_Mutation_p.W509*	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	690					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CACTGTTCTTCCACAACTACA	0.353000													13	37					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489685	237489685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237489685G>A	ENST00000272928.3	+	2	887	c.577G>A	c.(577-579)Gag>Aag	p.E193K		NM_020311.2	NP_064707.1			atypical chemokine receptor 3									p.E193K(1)									GTCCAACAATGAGACCTACTG	0.592000													33	116					0	0	1	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72958220	72958220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72958220G>A	ENST00000421285.3	+	16	1794	c.1794G>A	c.(1792-1794)gaG>gaA	p.E598E		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	598										NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						AGGAGGAGGAGATGAAGGTAG	0.627000													32	321					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84527518	84527518	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84527518G>A	ENST00000286744.5	+	8	952	c.727_splice	c.e8-1	p.R243_splice	ADAMTSL3_ENST00000567476.1_Splice_Site_p.R243_splice	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	243						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTTTCCCAGGAGAAGAAAAT	0.398000													21	117					0	0	1	0	0
IFIH1	64135	broad.mit.edu	37	2	163138964	163138964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163138964G>A	ENST00000263642.2	-	6	1613	c.1218C>T	c.(1216-1218)tcC>tcT	p.S406S		NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	406	Helicase ATP-binding.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						TAATATCACAGGACTTGACAA	0.373000													33	71					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17697186	17697186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:17697186C>T	ENST00000353383.1	+	3	1393	c.924C>T	c.(922-924)ctC>ctT	p.L308L	RAI1_ENST00000261641.6_Silent_p.L308L	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	308	Gln-rich.					cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		ACCAAAACCTCGCCAAGTATC	0.627000													34	68					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7310146	7310146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7310146C>T	ENST00000537408.1	+	16	3163	c.2625C>T	c.(2623-2625)gtC>gtT	p.V875V	CLSTN3_ENST00000331148.5_3'UTR|CLSTN3_ENST00000266546.6_Silent_p.V863V			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	863					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						TGCTCATGGTCGTCCTGGGCC	0.662000													11	26					0	0	1	0	0
NLRP6	171389	broad.mit.edu	37	11	280753	280753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:280753C>T	ENST00000534750.1	+	4	1224	c.1019C>T	c.(1018-1020)tCc>tTc	p.S340F	NLRP6_ENST00000312165.5_Missense_Mutation_p.S340F	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	340	NACHT.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGCCTGTGTTCCCCGCAGTGC	0.687000													23	41					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502394	90502394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90502394G>A	ENST00000325643.5	+	4	3058	c.2992G>A	c.(2992-2994)Gag>Aag	p.E998K		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GGCTGGGAACGAGGCATGGCT	0.582000													10	52					0	0	1	0	0
MAN1A1	4121	broad.mit.edu	37	6	119509578	119509578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:119509578C>T	ENST00000368468.3	-	11	2152	c.1711G>A	c.(1711-1713)Gcc>Acc	p.A571T		NM_005907.3	NP_005898.2	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	571					post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|skin(3)	24		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		ACCTCTACGGCTTCCCAGGCC	0.348000													43	89					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181420	128181420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:128181420C>T	ENST00000469083.1	-	2	3226	c.669G>A	c.(667-669)aaG>aaA	p.K223K	DNAJB8_ENST00000319153.3_Silent_p.K223K			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	223					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		TGAGCTGCTCCTTGCCGTTCA	0.642000													53	101					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70550872	70550872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70550872C>T	ENST00000260128.4	+	20	3137	c.2420C>T	c.(2419-2421)cCt>cTt	p.P807L	SULF1_ENST00000458141.2_Missense_Mutation_p.P807L|SULF1_ENST00000419716.3_Missense_Mutation_p.P807L|SULF1_ENST00000402687.4_Missense_Mutation_p.P807L|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	807					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AATACAGATCCTTATCAGGTA	0.348000													10	107					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87175226	87175226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87175226C>T	ENST00000265724.3	-	16	2257	c.1840G>A	c.(1840-1842)Gaa>Aaa	p.E614K	ABCB1_ENST00000543898.1_Missense_Mutation_p.E550K	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	614	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTCATGAGTTCATCATGATTT	0.383000													29	90					0	0	1	0	0
HLA-DQA1	3117	broad.mit.edu	37	6	32609298	32609298	+	Silent	SNP	C	C	T	rs36219014		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32609298C>T	ENST00000343139.5	+	2	396	c.294C>T	c.(292-294)atC>atT	p.I98I	HLA-DQA1_ENST00000374949.2_Silent_p.I98I|HLA-DQA1_ENST00000395363.1_Silent_p.I98I	NM_002122.3	NP_002113.2	P01909	DQA1_HUMAN	major histocompatibility complex, class II, DQ alpha 1	97	Alpha-1.		L -> M (in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07).|L -> V (in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03).		antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6						ACTTGAACATCATGATTAAAC	0.478000													44	23					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1263213	1263213	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1263213G>A	ENST00000308624.5	+	13	1206	c.1077_splice	c.e13+1	p.K359_splice	SNTG2_ENST00000407292.1_Splice_Site_p.K232_splice	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	359	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		AAGTTCACAAGGTAGGTATCT	0.433000													16	38					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50724778	50724778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:50724778G>A	ENST00000404971.1	-	15	4031	c.2692C>T	c.(2692-2694)Ctt>Ttt	p.L898F	NRXN1_ENST00000402717.3_Missense_Mutation_p.L850F|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401669.2_Missense_Mutation_p.L858F|NRXN1_ENST00000406859.3_Missense_Mutation_p.L858F|NRXN1_ENST00000405472.3_Missense_Mutation_p.L850F|NRXN1_ENST00000406316.2_Missense_Mutation_p.L858F	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	858					adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACAGAAGAAAGATACCGTCGT	0.408000													22	58					0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26860664	26860664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26860664G>A	ENST00000398145.2	-	11	1548	c.932C>T	c.(931-933)cCc>cTc	p.P311L	HPS4_ENST00000402105.3_Missense_Mutation_p.P306L|HPS4_ENST00000336873.5_Missense_Mutation_p.P311L|HPS4_ENST00000398141.1_Missense_Mutation_p.P324L	NM_022081.4	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	311					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						AGGGGATGTGGGATCTGGGGT	0.577000									Hermansky-Pudlak syndrome				24	78					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34164423	34164423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34164423C>T	ENST00000373381.4	-	24	4031	c.3855G>A	c.(3853-3855)cgG>cgA	p.R1285R	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Silent_p.R158R	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1245	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTCACTACCCCGCAGGCTGT	0.607000													10	105					0	0	1	0	0
MRPL51	51258	broad.mit.edu	37	12	6601615	6601615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6601615G>A	ENST00000229238.3	-	3	670	c.209C>T	c.(208-210)cCc>cTc	p.P70L	MRPL51_ENST00000543703.1_5'UTR|MRPL51_ENST00000543164.1_5'UTR	NM_016497.3	NP_057581.2	Q4U2R6	RM51_HUMAN	mitochondrial ribosomal protein L51	70					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome			kidney(2)|large_intestine(1)|lung(3)	6						CAGTTCTTTGGGGTGCTTTTC	0.443000													98	156					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6866924	6866924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6866924G>A	ENST00000299454.4	+	1	42	c.11G>A	c.(10-12)gGa>gAa	p.G4E	OR10A5_ENST00000379831.2_Missense_Mutation_p.G8E			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATGGCTATAGGAAACTGGACA	0.383000													66	206					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43473424	43473424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43473424G>A	ENST00000532038.1	-	14	1780	c.1645C>T	c.(1645-1647)Ctg>Ttg	p.L549L	ARHGAP27_ENST00000528384.1_Silent_p.L403L|ARHGAP27_ENST00000428638.1_Silent_p.L771L|ARHGAP27_ENST00000455881.1_Silent_p.L430L|ARHGAP27_ENST00000442348.1_Silent_p.L744L|ARHGAP27_ENST00000532891.2_Silent_p.L749L|ARHGAP27_ENST00000376922.2_Silent_p.L430L			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	771	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					AAGAGCTTCAGGGCTCCGGTG	0.632000													6	38					0	0	1	0	0
NTSR1	4923	broad.mit.edu	37	20	61386197	61386197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61386197C>T	ENST00000370501.3	+	2	1246	c.875C>T	c.(874-876)cCt>cTt	p.P292L		NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	292						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			GCCATCGAGCCTGGCAGGGTC	0.687000													12	29					0	0	1	0	0
UBXN11	91544	broad.mit.edu	37	1	26627455	26627455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26627455G>A	ENST00000314675.7	-	4	240	c.161C>T	c.(160-162)tCc>tTc	p.S54F	UBXN11_ENST00000374223.1_Intron|UBXN11_ENST00000374222.1_Missense_Mutation_p.S54F|UBXN11_ENST00000374221.3_Missense_Mutation_p.S54F|UBXN11_ENST00000535108.1_Intron|UBXN11_ENST00000357089.4_Intron|UBXN11_ENST00000374217.2_Intron|UBXN11_ENST00000436301.2_Intron	NM_001077262.1	NP_001070730.1	Q5T124	UBX11_HUMAN	UBX domain protein 11	54						cytoplasm|cytoskeleton				endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						GCCATAGCAGGAAGGGACTGA	0.617000													43	91					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4511239	4511239	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4511239C>T	ENST00000301286.3	-	3	2690	c.2691G>A	c.(2689-2691)ggG>ggA	p.G897G		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	897	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TCTGGACAGTCCCTTTGGCCA	0.602000													32	115					0	0	1	0	0
WNT8A	7478	broad.mit.edu	37	5	137423581	137423581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137423581G>A	ENST00000506684.1	+	3	618	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	WNT8A_ENST00000398754.1_Missense_Mutation_p.E110K			Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family, member 8A	110					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GGGTGACTTCGAAAACTGTGG	0.483000													66	175					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	44913862	44913862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:44913862C>T	ENST00000429094.2	-	19	2830	c.2326G>A	c.(2326-2328)Gaa>Aaa	p.E776K	NELL2_ENST00000452445.2_Missense_Mutation_p.E776K|NELL2_ENST00000437801.2_Missense_Mutation_p.E826K|NELL2_ENST00000551601.1_Missense_Mutation_p.E728K|NELL2_ENST00000333837.4_Missense_Mutation_p.E799K|NELL2_ENST00000549027.1_Missense_Mutation_p.E775K|NELL2_ENST00000395487.2_Missense_Mutation_p.E775K	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	776	VWFC 5.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		ACATTCATTTCGTCCAGGCAA	0.498000													15	60					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926313	1926313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1926313C>T	ENST00000399161.2	-	10	1975	c.1228G>A	c.(1228-1230)Gac>Aac	p.D410N	MYT1L_ENST00000428368.2_Missense_Mutation_p.D410N	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	410					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.D410N(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GTGGTATCGTCGTCCCGCTCA	0.582000													14	53					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20489922	20489922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20489922C>T	ENST00000573854.1	+	10	1318	c.1204C>T	c.(1204-1206)Ctg>Ttg	p.L402L	ACSM2A_ENST00000575690.1_Silent_p.L402L|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Silent_p.L402L|ACSM2A_ENST00000536134.1_Silent_p.L174L|ACSM2A_ENST00000417235.2_Silent_p.L323L|ACSM2A_ENST00000396104.2_Silent_p.L402L	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	402					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GGGCAACGTCCTGCCCCCCGG	0.502000													8	75					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156810752	156810752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156810752C>T	ENST00000368195.3	-	22	4203	c.3807G>A	c.(3805-3807)cgG>cgA	p.R1269R	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	1269					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCAGGGAGCCCCGGGCCCCCC	0.627000													7	20					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121008394	121008394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121008394G>A	ENST00000392793.1	+	11	3477	c.3206G>A	c.(3205-3207)aGg>aAg	p.R1069K	TECTA_ENST00000264037.2_Missense_Mutation_p.R1069K			O75443	TECTA_HUMAN	tectorin alpha	1069					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACAGACAACAGGGTCCACTGC	0.572000													9	46					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034098	52034098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52034098G>A	ENST00000346477.3	-	3	611	c.543C>T	c.(541-543)tcC>tcT	p.S181S	SIGLEC6_ENST00000359982.4_Silent_p.S181S|SIGLEC6_ENST00000391797.3_Silent_p.S170S|SIGLEC6_ENST00000343300.4_Silent_p.S181S|SIGLEC6_ENST00000436458.1_Silent_p.S145S|SIGLEC6_ENST00000425629.3_Silent_p.S181S	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	181	Ig-like C2-type 1.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CTGACATCCAGGAGAAGATGG	0.652000													34	100					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6312194	6312194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6312194G>A	ENST00000301452.4	-	3	393	c.316C>T	c.(316-318)Cgc>Tgc	p.R106C		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	106						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						AAATAGCAGCGGGGCATCCAT	0.587000													14	46					0	0	1	0	0
FCER2	2208	broad.mit.edu	37	19	7761754	7761754	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7761754C>T	ENST00000346664.5	-	8	638	c.426G>A	c.(424-426)cgG>cgA	p.R142R	FCER2_ENST00000360067.4_Silent_p.R141R|FCER2_ENST00000597921.1_Silent_p.R142R	NM_001220500.1|NM_002002.4	NP_001207429.1|NP_001993.2	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor for (CD23)	142					positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10						TCACCTCCTCCCGGAGTCTTT	0.587000													4	9					0	0	1	0	0
SLC17A4	10050	broad.mit.edu	37	6	25773505	25773505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25773505G>A	ENST00000377905.4	+	7	828	c.709G>A	c.(709-711)Gga>Aga	p.G237R	SLC17A4_ENST00000397076.2_Intron|SLC17A4_ENST00000439485.2_Intron	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	237					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTTCCTAGGAGGAATTGGCTG	0.443000													45	94					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102869434	102869434	+	Silent	SNP	C	C	T	rs147960415	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102869434C>T	ENST00000456098.1	-	2	425	c.207G>A	c.(205-207)agG>agA	p.R69R	IGF1_ENST00000307046.8_Silent_p.R69R|IGF1_ENST00000392904.1_Silent_p.R69R|IGF1_ENST00000424202.2_Silent_p.R53R|IGF1_ENST00000337514.6_Silent_p.R69R	NM_001111283.1	NP_001104753.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	69	B.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						AATAAAAGCCCCTGTCTCCAC	0.547000													15	60					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100190594	100190594	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100190594C>T	ENST00000241071.6	+	5	1069	c.747C>T	c.(745-747)atC>atT	p.I249I	FBXO24_ENST00000468962.1_Silent_p.I237I|FBXO24_ENST00000360609.2_Silent_p.I235I|PCOLCE-AS1_ENST00000544873.1_RNA|FBXO24_ENST00000465843.1_Silent_p.I235I|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000427939.2_Silent_p.I287I	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	249						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TCAAGCAGATCGTGCTGGTTG	0.552000													7	50					0	0	1	0	0
FAM76A	199870	broad.mit.edu	37	1	28081763	28081763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28081763C>T	ENST00000373954.6	+	7	759	c.657C>T	c.(655-657)gcC>gcT	p.A219A	FAM76A_ENST00000234549.7_Silent_p.A224A|FAM76A_ENST00000373949.1_Silent_p.A190A|FAM76A_ENST00000419687.2_Silent_p.A139A|FAM76A_ENST00000010299.6_Silent_p.A253A|FAM76A_ENST00000530324.1_Silent_p.A219A	NM_001143912.1|NM_152660.2	NP_001137384.1|NP_689873.1	Q8TAV0	FA76A_HUMAN	family with sequence similarity 76, member A	219										endometrium(4)|kidney(2)|large_intestine(1)|lung(2)	9		Colorectal(325;0.000147)|all_lung(284;0.00181)|Lung NSC(340;0.00278)|Renal(390;0.00357)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00253)|KIRC - Kidney renal clear cell carcinoma(1967;0.00292)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)		TCATCATTGCCCAACTGAAGG	0.403000													57	129					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182558	140182558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140182558G>A	ENST00000522353.2	+	1	1776	c.1776G>A	c.(1774-1776)gcG>gcA	p.A592A	PCDHA3_ENST00000532566.2_Silent_p.A592A|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTGGTAGCGAAGGTGCGCG	0.687000													30	93					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762896	24762896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24762896G>A	ENST00000376451.2	+	2	1000	c.740G>A	c.(739-741)gGa>gAa	p.G247E	KIAA1217_ENST00000307544.6_Missense_Mutation_p.G247E|KIAA1217_ENST00000458595.1_Missense_Mutation_p.G529E|KIAA1217_ENST00000396446.1_Missense_Mutation_p.G247E|KIAA1217_ENST00000430453.2_Missense_Mutation_p.G450E|KIAA1217_ENST00000376462.1_Missense_Mutation_p.G449E|KIAA1217_ENST00000396445.1_Missense_Mutation_p.G247E|KIAA1217_ENST00000376452.3_Missense_Mutation_p.G529E|KIAA1217_ENST00000376454.3_Missense_Mutation_p.G529E			Q5T5P2	SKT_HUMAN	KIAA1217	529					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AGCGCTGCAGGATTATCCAGC	0.552000													22	75					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80615938	80615938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80615938C>T	ENST00000458043.2	+	6	381	c.375C>T	c.(373-375)ttC>ttT	p.F125F	OTOGL_ENST00000547103.1_Silent_p.F125F	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTGAAACATTCGATGGCATCT	0.413000													24	75					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424593	56424593	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56424593C>T	ENST00000588751.1	-	5	614	c.590G>A	c.(589-591)tGg>tAg	p.W197*	NLRP13_ENST00000342929.3_Nonsense_Mutation_p.W197*			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	197							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTCTTTAGGCCAACTGATGTT	0.488000													12	168					0	0	1	0	0
IFIT1B	439996	broad.mit.edu	37	10	91143629	91143629	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:91143629C>T	ENST00000371809.3	+	2	639	c.559C>T	c.(559-561)Cgc>Tgc	p.R187C	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	187							binding			endometrium(2)|large_intestine(3)|lung(8)	13						CACCGTCTATCGCCTGGATAA	0.438000													110	229					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42546860	42546860	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42546860C>T	ENST00000262895.3	-	11	1316	c.1317G>A	c.(1315-1317)ggG>ggA	p.G439G	GRIK5_ENST00000593562.1_Silent_p.G439G|GRIK5_ENST00000301218.4_Silent_p.G439G	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	439						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	AGCGTTCGTTCCCCGACAGGG	0.652000													16	33					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230456299	230456299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230456299C>T	ENST00000341772.4	-	2	716	c.582G>A	c.(580-582)gtG>gtA	p.V194V		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	194					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TTCTCACCTCCACTTGATCCC	0.428000													14	38					0	0	1	0	0
SPACA1	81833	broad.mit.edu	37	6	88757792	88757792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88757792G>A	ENST00000237201.1	+	1	286	c.169G>A	c.(169-171)Gag>Aag	p.E57K		NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	57						integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		CAACGACAGCGAGACCGCGGA	0.692000													8	3					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79674064	79674064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79674064C>T	ENST00000571730.1	+	4	605	c.474C>T	c.(472-474)ctC>ctT	p.L158L	SLC25A10_ENST00000541223.1_Silent_p.L158L|MRPL12_ENST00000333676.3_Silent_p.L158L			Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	GCATCAACCTCGTCCAGGTCT	0.582000													20	43					0	0	1	0	0
TNFRSF17	608	broad.mit.edu	37	16	12060155	12060155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:12060155G>A	ENST00000053243.1	+	2	452	c.234G>A	c.(232-234)agG>agA	p.R78R	RP11-166B2.1_ENST00000532936.1_Intron|TNFRSF17_ENST00000396495.3_Intron	NM_001192.2	NP_001183.2	Q02223	TNR17_HUMAN	tumor necrosis factor receptor superfamily, member 17	78					cell proliferation|multicellular organismal development	endomembrane system|integral to membrane|plasma membrane				large_intestine(3)|lung(3)	6						TTTTGCTAAGGAAGATAAACT	0.383000			T	IL2	intestinal T-cell lymphoma								29	92					0	0	1	0	0
ASB11	140456	broad.mit.edu	37	X	15307707	15307707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:15307707C>T	ENST00000537676.1	-	5	583	c.511G>A	c.(511-513)Gag>Aag	p.E171K	ASB11_ENST00000380470.3_Missense_Mutation_p.E175K|ASB11_ENST00000480796.1_Missense_Mutation_p.E192K|ASB11_ENST00000344384.4_Missense_Mutation_p.E171K			Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box containing 11	192					intracellular signal transduction					breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(1)	16	Hepatocellular(33;0.183)					TGAGGCACCTCATGGTCAATG	0.433000													100	74					0	0	1	0	0
POTED	317754	broad.mit.edu	37	21	14982958	14982958	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:14982958C>T	ENST00000299443.5	+	1	461	c.409C>T	c.(409-411)Cga>Tga	p.R137*		NM_174981.3|NM_207355.2	NP_778146.2|NP_997238.2	Q86YR6	POTED_HUMAN	POTE ankyrin domain family, member D	137						plasma membrane				central_nervous_system(1)|large_intestine(10)|liver(2)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	33						CCACATCCGTCGAGAAGATCT	0.587000													7	56					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20683155	20683155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20683155C>T	ENST00000404938.2	+	7	1230	c.578C>T	c.(577-579)tCg>tTg	p.S193L		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	379					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity	p.S193L(1)|p.S193*(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TCTACTTTTTCGATTGGCCTG	0.423000													28	112					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31322961	31322961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31322961G>A	ENST00000265071.2	+	12	2184	c.1919G>A	c.(1918-1920)cGa>cAa	p.R640Q		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	640					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.R640Q(1)		NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AGGCGGCAGCGAAAAAAAGAG	0.453000													30	63					0	0	1	0	0
VIPR1	7433	broad.mit.edu	37	3	42577678	42577678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42577678G>A	ENST00000433647.1	+	14	1780	c.1156G>A	c.(1156-1158)Ggc>Agc	p.G386S	VIPR1_ENST00000438259.2_Missense_Mutation_p.G217S|VIPR1_ENST00000543411.1_Missense_Mutation_p.G379S|VIPR1_ENST00000325123.4_Missense_Mutation_p.G427S	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	427					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		AGGCAGCAACGGCGCCACGTG	0.692000													3	13					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344279	56344279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56344279C>T	ENST00000526812.2	-	1	984	c.919G>A	c.(919-921)Gga>Aga	p.G307R		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						AAGGATTTTCCCCTAATCATT	0.373000													74	197					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113857486	113857486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113857486G>A	ENST00000355556.2	+	7	1203	c.970G>A	c.(970-972)Gag>Aag	p.E324K	HTR3A_ENST00000535865.1_Intron|HTR3A_ENST00000506841.2_Missense_Mutation_p.E318K|HTR3A_ENST00000299961.5_Intron|HTR3A_ENST00000375498.2_Intron|HTR3A_ENST00000504030.2_Intron	NM_213621.3	NP_998786.2	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	305					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TCAGTCTGGTGAGAAACCCGC	0.597000													26	137					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374056	31374056	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31374056C>T	ENST00000268296.4	+	12	1462	c.1341C>T	c.(1339-1341)gcC>gcT	p.A447A	ITGAX_ENST00000562522.1_Silent_p.A447A	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	447					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GGATGAAGGCCGAAGTCACGG	0.652000													12	35					0	0	1	0	0
TTC24	164118	broad.mit.edu	37	1	156555535	156555535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156555535C>T	ENST00000368236.3	+	9	1523	c.1487C>T	c.(1486-1488)tCg>tTg	p.S496L	TTC24_ENST00000368237.3_Missense_Mutation_p.S496L|TTC24_ENST00000495690.1_3'UTR	NM_001105669.2	NP_001099139.2	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	496							binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	20	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGAATCATTCGCACCATCTA	0.512000													35	84					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28436193	28436193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28436193G>A	ENST00000261609.7	-	55	8675	c.8567C>T	c.(8566-8568)tCc>tTc	p.S2856F		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2856	DOC.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTTATTCAGGGAATTTCCACC	0.368000													11	45					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3659212	3659212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:3659212C>T	ENST00000382622.3	+	3	762	c.372C>T	c.(370-372)atC>atT	p.I124I	PRMT8_ENST00000261252.4_3'UTR|PRMT8_ENST00000452611.2_Silent_p.I115I	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	124					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			GTACTGGGATCCTTTCCATGT	0.572000													49	91					0	0	1	0	0
RAB3B	5865	broad.mit.edu	37	1	52442595	52442595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:52442595G>A	ENST00000371655.3	-	2	407	c.195C>T	c.(193-195)taC>taT	p.Y65Y		NM_002867.3	NP_002858.2	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	65					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9						TCTCGTGACGGTAGACTGTCT	0.562000													26	59					0	0	1	0	0
SAPCD2	89958	broad.mit.edu	37	9	139960772	139960772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139960772G>A	ENST00000409687.3	-	2	753	c.626C>T	c.(625-627)cCc>cTc	p.P209L		NM_178448.3	NP_848543.2	Q86UD0	CI140_HUMAN	suppressor APC domain containing 2	209						cytoplasm|nucleus											TCGGGCACGGGGAGCCCGCCG	0.701000													4	19					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	21698984	21698984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:21698984G>A	ENST00000382148.3	-	1	413	c.77C>T	c.(76-78)tCt>tTt	p.S26F	KCNIP4_ENST00000447367.2_Intron|KCNIP4_ENST00000382152.2_Intron	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	0	KIS (By similarity).					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				TGTATGAAGAGAACCTGTTAA	0.348000													23	69					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160109743	160109743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160109743C>T	ENST00000361216.3	+	22	3092	c.3003C>T	c.(3001-3003)gtC>gtT	p.V1001V	ATP1A2_ENST00000392233.3_Silent_p.V990V	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1001					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			ATGATGAGGTCCGAAAGCTCA	0.577000													29	124					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906819	13906819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13906819G>A	ENST00000279593.3	-	3	651	c.442C>T	c.(442-444)Cca>Tca	p.P148S		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	148					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCAATTGATGGGCCAAACTGG	0.398000													5	45					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159170712	159170712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159170712G>A	ENST00000368125.4	+	9	1354	c.1197G>A	c.(1195-1197)taG>taA	p.*399*	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000368124.4_Silent_p.*433*|CADM3_ENST00000497636.1_3'UTR	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	0					adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					ATTTCATCTAGAGGCGCCTGC	0.642000													7	63					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95085787	95085787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95085787G>A	ENST00000553947.1	+	6	1862	c.974G>A	c.(973-975)aGa>aAa	p.R325K	SERPINA3_ENST00000467132.1_Missense_Mutation_p.R300K|SERPINA3_ENST00000482740.1_Missense_Mutation_p.R82K|SERPINA3_ENST00000393080.4_Missense_Mutation_p.R300K|SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000393078.3_Missense_Mutation_p.R300K			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	300					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		AAGCGGTGGAGAGACTCTCTG	0.557000													11	47					0	0	1	0	0
LRRC43	254050	broad.mit.edu	37	12	122677421	122677421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122677421G>A	ENST00000339777.4	+	7	1247	c.1219G>A	c.(1219-1221)Gag>Aag	p.E407K	LRRC43_ENST00000425921.1_Missense_Mutation_p.E222K	NM_152759.4	NP_689972.3	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43	407	Glu-rich.									NS(1)|endometrium(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(2)	19	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		GTCTGAGGTGGAGGAGTCAGG	0.547000													20	42					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10448673	10448673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10448673G>A	ENST00000245503.5	-	5	879	c.495C>T	c.(493-495)ttC>ttT	p.F165F	MYH2_ENST00000397183.2_Silent_p.F165F|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Silent_p.F165F	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	165	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CAGTCAGCATGAACTGATAGG	0.527000													79	183					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52130793	52130793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52130793G>A	ENST00000222107.4	-	6	1342	c.1204C>T	c.(1204-1206)Ctc>Ttc	p.L402F	SIGLEC5_ENST00000429354.3_Missense_Mutation_p.L402F|SIGLEC5_ENST00000534261.2_Missense_Mutation_p.L402F|SIGLEC5_ENST00000599649.1_Missense_Mutation_p.L402F|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.L402F			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	402					cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TCGGAGCTGAGCCCCCCGTGG	0.632000													17	81					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10409243	10409243	+	Missense_Mutation	SNP	G	G	A	rs142560385	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10409243G>A	ENST00000226207.5	-	19	2154	c.2060C>T	c.(2059-2061)gCc>gTc	p.A687V	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	687	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						ATGCTCCATGGCACCTAAAAG	0.473000													7	54					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4222756	4222756	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4222756C>T	ENST00000600132.1	+	20	3537	c.3261C>T	c.(3259-3261)ctC>ctT	p.L1087L	ANKRD24_ENST00000318934.4_Silent_p.L1087L|ANKRD24_ENST00000262970.5_Silent_p.L1177L	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1087										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TGGAGGCTCTCCGTGACCAGG	0.572000													8	18					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60165033	60165033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:60165033G>A	ENST00000261187.4	+	3	415	c.251G>A	c.(250-252)gGc>gAc	p.G84D	SLC16A7_ENST00000543448.1_5'UTR|SLC16A7_ENST00000552432.1_Missense_Mutation_p.G84D|SLC16A7_ENST00000552024.1_Missense_Mutation_p.G84D|SLC16A7_ENST00000547379.1_Missense_Mutation_p.G84D	NM_001270622.1|NM_001270623.1|NM_004731.3	NP_001257551.1|NP_001257552.1|NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	84						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	AATAAATACGGCAGCCGGCCG	0.443000													28	188					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8808219	8808219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8808219C>T	ENST00000324436.3	-	1	953	c.833G>A	c.(832-834)cGg>cAg	p.R278Q		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	278						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						CTTCAGAGTCCGCTTGTACTC	0.627000													15	46					0	0	1	0	0
OOEP	441161	broad.mit.edu	37	6	74079371	74079371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:74079371G>A	ENST00000370359.5	-	1	144	c.145C>T	c.(145-147)Cct>Tct	p.P49S	OOEP_ENST00000370363.1_Intron	NM_001080507.2	NP_001073976.1	A6NGQ2	OOEP_HUMAN	oocyte expressed protein	49	KH; atypical.					cytoplasm				large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	8						AACACCAAAGGGTCTCTCAGT	0.612000													14	103					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6748162	6748162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6748162G>A	ENST00000229243.2	-	9	1560	c.1467C>T	c.(1465-1467)tcC>tcT	p.S489S	ACRBP_ENST00000414226.2_Silent_p.S456S|ACRBP_ENST00000542357.1_5'UTR	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	489						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						GGCTTTTGAAGGAACAGTAGT	0.532000													9	97					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52353881	52353881	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52353881C>T	ENST00000296585.5	+	10	1266	c.1123C>T	c.(1123-1125)Cag>Tag	p.Q375*		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	375					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AGACAACTTTCAGATGGAAAT	0.363000													21	69					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33956124	33956124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33956124G>A	ENST00000379238.1	-	11	936	c.819C>T	c.(817-819)ttC>ttT	p.F273F	UBAP2_ENST00000379239.4_Intron|UBAP2_ENST00000539807.1_Silent_p.F28F|UBAP2_ENST00000418786.2_Silent_p.F220F|UBAP2_ENST00000449054.1_Silent_p.F273F|UBAP2_ENST00000360802.1_Silent_p.F273F			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	273										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		ATGAGGCAGTGAAGACCTTTG	0.348000													15	84					0	0	1	0	0
MTAP	4507	broad.mit.edu	37	9	21859391	21859391	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21859391C>T	ENST00000380172.4	+	7	986	c.780C>T	c.(778-780)tcC>tcT	p.S260S	MTAP_ENST00000460874.2_Silent_p.S277S|RP11-145E5.5_ENST00000404796.2_Intron|MTAP_ENST00000580900.1_Silent_p.S260S|RP11-70L8.4_ENST00000581788.1_RNA	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	260					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	AGATAGGGTCCACAGAATGGT	0.443000													11	32					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944846	43944846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43944846C>T	ENST00000389420.3	-	2	318	c.319G>A	c.(319-321)Gtg>Atg	p.V107M	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.V107M	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	107						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCCAAGTGCACCTCGGTGTAG	0.662000													7	35					0	0	1	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148715266	148715266	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148715266G>C	ENST00000296721.4	+	18	2362	c.2264G>C	c.(2263-2265)aGg>aCg	p.R755T	AFAP1L1_ENST00000515000.1_Intron	NM_001146337.1|NM_152406.2	NP_001139809.1|NP_689619.1	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	755							protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCAAGGAAGGGTGCTACAG	0.488000													39	112					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36215909	36215909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36215909C>T	ENST00000222270.7	+	10	3449	c.3449C>T	c.(3448-3450)cCc>cTc	p.P1150L	WBP7_ENST00000420124.1_Missense_Mutation_p.P1150L|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					GCCCCTGGCCCCTTTGCTTCT	0.592000													29	41					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68650889	68650889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68650889C>T	ENST00000423218.2	-	6	602	c.507G>A	c.(505-507)ctG>ctA	p.L169L	ITGA11_ENST00000562826.1_5'UTR|ITGA11_ENST00000315757.7_Silent_p.L169L			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	169	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	TGGAGCCATCCAGGACAATGA	0.527000													24	31					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323157	61323157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61323157C>T	ENST00000283752.5	-	8	1050	c.907G>A	c.(907-909)Gga>Aga	p.G303R	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.G251R	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	303					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						TCCACCATTCCCATGGTTCTC	0.507000													25	123					0	0	1	0	0
OR3A2	4995	broad.mit.edu	37	17	3181574	3181574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3181574G>A	ENST00000408891.2	-	1	694	c.656C>T	c.(655-657)cCt>cTt	p.P219L		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	219					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GAGAACCAAAGGTGTGCCTGC	0.557000													11	53					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887759	47887759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47887759G>A	ENST00000396105.1	-	3	836	c.590C>T	c.(589-591)tCc>tTc	p.S197F	ZNFX1_ENST00000371752.1_Missense_Mutation_p.S197F|ZNFX1_ENST00000371754.4_Missense_Mutation_p.S197F	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	197							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ATCCATTTTGGAGCTACAAGC	0.448000													39	118					0	0	1	0	0
ISOC1	51015	broad.mit.edu	37	5	128440889	128440889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128440889C>T	ENST00000173527.5	+	3	457	c.441C>T	c.(439-441)gcC>gcT	p.A147A		NM_016048.2	NP_057132.2	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	147						peroxisome	catalytic activity			kidney(2)|lung(7)	9		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		TGCAAGGGGCCCGGATTTTAG	0.343000													15	73					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92624013	92624013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92624013G>A	ENST00000298047.6	+	27	13521	c.13504G>A	c.(13504-13506)Gaa>Aaa	p.E4502K	FAT3_ENST00000533797.1_Missense_Mutation_p.E805K|FAT3_ENST00000409404.2_Missense_Mutation_p.E4470K|FAT3_ENST00000489716.1_3'UTR|FAT3_ENST00000525166.1_Missense_Mutation_p.E4352K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4502	Pro-rich.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTCCCCAACGAAACGGATTT	0.592000										TCGA Ovarian(4;0.039)			18	41					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111398117	111398117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111398117G>A	ENST00000265162.5	+	1	889	c.547G>A	c.(547-549)Gat>Aat	p.D183N		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	183					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CAGCAGTGGAGATGGCCTGTA	0.572000													40	93					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752368	62752368	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:62752368C>T	ENST00000331425.6	-	0	1067					NR_003952.1																						TAGTAAGGTTCGAGGATAAGC	0.428000													9	24					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52548200	52548200	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52548200C>T	ENST00000321725.6	+	33	3593	c.3517C>T	c.(3517-3519)Ctg>Ttg	p.L1173L		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1173	FAS1 4.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CAACCGCTCCCTGGAGGCCCA	0.642000													18	68					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50405665	50405665	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50405665C>T	ENST00000435965.1	-	25	2241	c.2066_splice	c.e25-1	p.E690_splice	CACNA2D2_ENST00000423994.2_Splice_Site_p.E690_splice|CACNA2D2_ENST00000429770.1_Splice_Site_p.E683_splice|CACNA2D2_ENST00000424201.2_Splice_Site_p.E683_splice|CACNA2D2_ENST00000266039.3_Splice_Site_p.E683_splice|CACNA2D2_ENST00000479441.1_Splice_Site_p.E690_splice|CACNA2D2_ENST00000395083.1_Splice_Site_p.E683_splice|CACNA2D2_ENST00000360963.3_Splice_Site_p.E614_splice			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	690					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TTGCAGTACTCTCTAGGGATG	0.537000													52	134					0	0	1	0	0
ENTHD2	146705	broad.mit.edu	37	17	79203038	79203038	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79203038G>A	ENST00000374769.2	-	13	1493	c.1016C>T	c.(1015-1017)tCc>tTc	p.S339F	AC027601.1_ENST00000575922.1_RNA|ENTHD2_ENST00000300714.3_Missense_Mutation_p.S423F					ENTH domain containing 2																		TGGAATGGGGGAGGCATCTGG	0.687000													8	8					0	0	1	0	0
C9orf135	138255	broad.mit.edu	37	9	72471531	72471531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72471531G>A	ENST00000377197.3	+	3	409	c.322G>A	c.(322-324)Gaa>Aaa	p.E108K	C9orf135_ENST00000527647.1_Missense_Mutation_p.E108K|C9orf135_ENST00000466872.2_3'UTR	NM_001010940.1	NP_001010940.1	Q5VTT2	CI135_HUMAN	chromosome 9 open reading frame 135	108						integral to membrane				endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						AGAATGGGTTGAAATGAAGAG	0.338000													24	58					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69348988	69348988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:69348988G>A	ENST00000260364.5	+	17	2497	c.2196G>A	c.(2194-2196)aaG>aaA	p.K732K	NOX5_ENST00000455873.3_Silent_p.K715K|NOX5_ENST00000448182.3_Silent_p.K704K|NOX5_ENST00000530406.2_Silent_p.K722K|NOX5_ENST00000388866.3_Silent_p.K750K			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	750					angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						AGGTGCTGAAGGGCCATTGTG	0.537000													58	66					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196689128	196689128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196689128C>T	ENST00000312428.6	-	49	9242	c.9142G>A	c.(9142-9144)Gaa>Aaa	p.E3048K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3048	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGAAGAGGTTCCAAAATAGGA	0.353000													30	119					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43503703	43503703	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43503703G>A	ENST00000300215.3	-	4	1007	c.550C>T	c.(550-552)Cag>Tag	p.Q184*	EPB42_ENST00000540029.1_Nonsense_Mutation_p.Q76*|EPB42_ENST00000441366.2_Nonsense_Mutation_p.Q154*			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	154					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		TCCATGCGCTGAGCCTCATTC	0.582000													30	89					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29284912	29284912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29284912G>A	ENST00000266943.6	-	4	1498	c.1129C>T	c.(1129-1131)Cgt>Tgt	p.R377C	SLC46A3_ENST00000380814.4_Missense_Mutation_p.R377C	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	377					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		TCAGTCGAACGAACCACTTTT	0.388000													31	95					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795591	142795591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142795591C>T	ENST00000370498.1	-	2	840	c.87G>A	c.(85-87)gaG>gaA	p.E29E		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	29										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGTTCGGTGCCTCCTGCATCT	0.418000													20	21					0	0	1	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940217	67940217	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:67940217G>A	ENST00000357461.2	-	3	833	c.424C>T	c.(424-426)Ctc>Ttc	p.L142F	TMEM229B_ENST00000557006.1_Missense_Mutation_p.L142F	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	142						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						TCGAAGCGGAGGCGGAGGGTG	0.657000													16	41					0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38183162	38183162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38183162G>A	ENST00000394126.1	-	16	2149	c.1731C>T	c.(1729-1731)acC>acT	p.T577T	MED24_ENST00000394127.2_Silent_p.T539T|MED24_ENST00000501516.3_Silent_p.T571T|MED24_ENST00000394128.2_Silent_p.T552T|MED24_ENST00000356271.3_Silent_p.T539T			O75448	MED24_HUMAN	mediator complex subunit 24	552					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					ACTCCACTTTGGTGGAGTCGG	0.642000											OREG0024386	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	11					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50733414	50733414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50733414C>T	ENST00000300589.2	+	2	194	c.89C>T	c.(88-90)tCg>tTg	p.S30L	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	30	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GAAATGTGCTCGCAGGAGGCT	0.612000													88	166					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386727	56386727	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56386727G>A	ENST00000355701.3	-	22	4776	c.3906C>T	c.(3904-3906)ccC>ccT	p.P1302P	BZRAP1_ENST00000268893.6_Silent_p.P1242P|BZRAP1_ENST00000343736.4_Silent_p.P1302P	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1302						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCTCACAAAAGGGGTCGGGCT	0.587000													16	39					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122805572	122805572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:122805572C>T	ENST00000227349.2	+	5	1720	c.1423C>T	c.(1423-1425)Caa>Taa	p.Q475*	C11orf63_ENST00000531316.1_Nonsense_Mutation_p.Q475*	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	475										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		ACACAAAGACCAAGAAGAGAA	0.398000													49	138					0	0	1	0	0
DMRTC2	63946	broad.mit.edu	37	19	42351874	42351874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42351874C>T	ENST00000269945.3	+	3	346	c.295C>T	c.(295-297)Ctg>Ttg	p.L99L	DMRTC2_ENST00000596827.1_Silent_p.L99L|DMRTC2_ENST00000602098.1_3'UTR	NM_001040283.1	NP_001035373.1	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	99					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						AAAGAAGCACCTGATGAGGAG	0.597000													6	10					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84270552	84270552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84270552C>T	ENST00000568181.1	-	2	660	c.540G>A	c.(538-540)agG>agA	p.R180R	KCNG4_ENST00000308251.4_Silent_p.R180R			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	180						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GTACGTCCTCCCTGTGCAGCT	0.677000													14	29					0	0	1	0	0
MAP2K5	5607	broad.mit.edu	37	15	67995676	67995676	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:67995676C>T	ENST00000178640.5	+	16	1601	c.972_splice	c.e16-1	p.P325_splice	MAP2K5_ENST00000354498.5_Splice_Site_p.P289_splice|MAP2K5_ENST00000395476.2_Splice_Site_p.P325_splice|MAP2K5_ENST00000340972.4_Splice_Site_p.P135_splice	NM_145160.2	NP_660143.1	Q13163	MP2K5_HUMAN	mitogen-activated protein kinase kinase 5	325	Protein kinase.				nerve growth factor receptor signaling pathway		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|skin(1)	16						TTCTTGCAGCCTGAAAGGATT	0.463000													35	85					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100191794	100191794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100191794C>T	ENST00000554176.1	+	8	1420	c.754C>T	c.(754-756)Cgc>Tgc	p.R252C	CYP46A1_ENST00000261835.3_Missense_Mutation_p.R415C|CYP46A1_ENST00000423126.2_Missense_Mutation_p.R318C			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	415					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CAACCCCGATCGCTTCGGCCC	0.612000													11	54					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37067192	37067192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37067192C>T	ENST00000231790.2	+	12	1319	c.1103C>T	c.(1102-1104)tCg>tTg	p.S368L	MLH1_ENST00000539477.1_Missense_Mutation_p.S127L|MLH1_ENST00000455445.2_Missense_Mutation_p.S127L|MLH1_ENST00000435176.1_Missense_Mutation_p.S270L|MLH1_ENST00000458205.2_Missense_Mutation_p.S127L|MLH1_ENST00000536378.1_Missense_Mutation_p.S127L	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	368					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						AGTCTGACCTCGTCTTCTACT	0.423000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				43	68					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56058286	56058286	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56058286A>C	ENST00000313022.2	-	1	280	c.253T>G	c.(253-255)Tta>Gta	p.L85V		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					GAAGTCAGTAAGTTCGCTAAG	0.418000													134	346					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119652620	119652620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119652620G>A	ENST00000379735.5	-	21	2993	c.2722C>T	c.(2722-2724)Cgt>Tgt	p.R908C	SEC24D_ENST00000429811.2_3'UTR|SEC24D_ENST00000280551.6_Missense_Mutation_p.R907C|SEC24D_ENST00000505134.1_5'UTR|SEC24D_ENST00000511481.1_Missense_Mutation_p.R538C	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	907					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding	p.R907C(1)		breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						TCAGAGCAACGAACGGCAGCA	0.483000													45	98					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52361784	52361784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52361784C>T	ENST00000296585.5	+	15	2063	c.1920C>T	c.(1918-1920)gcC>gcT	p.A640A		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	640					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CTATTGGTGCCTTTGGACAAG	0.458000													38	98					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49411662	49411662	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49411662G>C	ENST00000299191.3	+	2	288	c.171G>C	c.(169-171)gtG>gtC	p.V57V		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	57										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						CCAAAGTGGTGACAGTCCTTA	0.552000													7	12					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427392	119427392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119427392G>A	ENST00000369429.3	-	8	1781	c.1772C>T	c.(1771-1773)cCa>cTa	p.P591L	TBX15_ENST00000207157.3_Missense_Mutation_p.P485L			Q96SF7	TBX15_HUMAN	T-box 15	591						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.P485L(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GGAGGAGCCTGGAACTGCCCC	0.557000													28	88					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69046395	69046395	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69046395G>T	ENST00000295381.3	+	9	1560	c.1141G>T	c.(1141-1143)Ggc>Tgc	p.G381C	ARHGAP25_ENST00000409202.3_Missense_Mutation_p.G382C|ARHGAP25_ENST00000497079.1_Missense_Mutation_p.G375C|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.G375C|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.G342C|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.G75C|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.G374C	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	381					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						AAGCTCTGTAGGCTGGGATGC	0.522000													28	120					8.16721e-17	8.21313e-17	1	1	0
LINC00639	283547	broad.mit.edu	37	14	39304870	39304870	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:39304870G>A	ENST00000553932.1	-	0	3692																											TAATGGAGGTGGATCTTTAAG	0.488000													11	21					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49686399	49686399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49686399C>T	ENST00000252826.5	+	12	1799	c.1673C>T	c.(1672-1674)cCc>cTc	p.P558L	TRPM4_ENST00000427978.2_Missense_Mutation_p.P558L|TRPM4_ENST00000355712.5_Missense_Mutation_p.P204L	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	558					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGGCAGGCCCCCTGGAGCGAC	0.627000													20	41					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116757239	116757239	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116757239C>T	ENST00000331677.3	+	7	2052	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	DSE_ENST00000359564.2_Silent_p.F536F|DSE_ENST00000537543.1_Silent_p.F555F|DSE_ENST00000452085.3_Silent_p.F536F			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	536					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		GGGTGGTTTTCATCCGAGGAG	0.493000													18	26					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23305332	23305332	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:23305332G>A	ENST00000358689.4	-	4	508	c.273C>T	c.(271-273)atC>atT	p.I91I	ENTPD4_ENST00000356206.6_Silent_p.I91I|ENTPD4_ENST00000417069.2_Silent_p.I91I	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	91					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		AGTCCACCACGATCCCATAGT	0.458000													30	106					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37744643	37744643	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37744643G>A	ENST00000539465.1	+	16	3207	c.2614G>A	c.(2614-2616)Gag>Aag	p.E872K	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Missense_Mutation_p.E872K			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	872						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CTATGACAGGGAGCCCTACCT	0.592000													16	43					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81110910	81110910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81110910C>T	ENST00000228644.3	+	1	220	c.68C>T	c.(67-69)tCc>tTc	p.S23F		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	23					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						TGCATACCGTCCCCCGAGGGT	0.617000													14	41					0	0	1	0	0
IARS2	55699	broad.mit.edu	37	1	220267642	220267642	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:220267642C>T	ENST00000302637.5	+	1	188	c.84C>T	c.(82-84)ccC>ccT	p.P28P	IARS2_ENST00000366922.1_5'UTR	NM_018060.3	NP_060530.3	Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	28					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	CCCGCCTTCCCTGCAGCCCGG	0.711000													6	30					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539788	55539788	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55539788C>T	ENST00000220676.1	+	4	3494	c.3346C>T	c.(3346-3348)Ccc>Tcc	p.P1116S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1116					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGCAGGTGTTCCCTTTCATTC	0.423000													19	58					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99182197	99182197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99182197C>T	ENST00000074304.5	+	21	2655	c.2262C>T	c.(2260-2262)tcC>tcT	p.S754S	INPP4A_ENST00000409016.3_Silent_p.S715S|INPP4A_ENST00000523221.1_Silent_p.S754S|INPP4A_ENST00000545415.1_Silent_p.S715S|INPP4A_ENST00000409540.3_Silent_p.S715S|INPP4A_ENST00000409851.3_Silent_p.S749S|INPP4A_ENST00000409463.1_Silent_p.S83S	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	754					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						CCAGCGCCTCCGCAGACATGC	0.517000													7	85					0	0	1	0	0
PHC3	80012	broad.mit.edu	37	3	169863233	169863233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169863233G>A	ENST00000494943.1	-	6	682	c.614C>T	c.(613-615)tCc>tTc	p.S205F	PHC3_ENST00000495893.1_Missense_Mutation_p.S217F|PHC3_ENST00000467570.1_Missense_Mutation_p.S164F			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	205	Ser-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			AGACTGACAGGAAGATGACGA	0.433000													13	50					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55081805	55081805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55081805C>T	ENST00000302250.2	-	3	463	c.303G>A	c.(301-303)ggG>ggA	p.G101G	FAM151A_ENST00000371304.2_Silent_p.G101G|ACOT11_ENST00000371316.3_Intron	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	101						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTGTGCCGAGCCCTTCTACAT	0.512000													10	75					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332299	70332299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70332299G>A	ENST00000338508.4	-	32	4101	c.4102C>T	c.(4102-4104)Ccc>Tcc	p.P1368S	SHANK2_ENST00000449833.2_Missense_Mutation_p.P772S|SHANK2_ENST00000423696.2_Missense_Mutation_p.P988S|SHANK2_ENST00000409161.1_Missense_Mutation_p.P771S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	988					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACGGTGGTGGGCTCGGGGGCA	0.627000													20	30					0	0	1	0	0
SGCG	6445	broad.mit.edu	37	13	23894882	23894882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:23894882C>T	ENST00000218867.3	+	7	809	c.685C>T	c.(685-687)Cat>Tat	p.H229Y	SGCG_ENST00000545013.1_Missense_Mutation_p.H229Y|SGCG_ENST00000537476.1_Missense_Mutation_p.H229Y	NM_000231.2	NP_000222.1	Q13326	SGCG_HUMAN	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	229					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		TATTCTTTTTCATAGTAGTGA	0.438000													14	33					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110754499	110754499	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110754499C>T	ENST00000369787.3	+	1	405	c.378C>T	c.(376-378)ttC>ttT	p.F126F	KCNC4_ENST00000438661.2_Silent_p.F126F|KCNC4_ENST00000413138.3_Silent_p.F126F	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	126					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGCCGCTCTTCGAAGAGGAGC	0.657000													6	57					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9106080	9106080	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9106080C>T	ENST00000383836.3	-	5	1099	c.672_splice	c.e5+1	p.K224_splice	SRGAP3_ENST00000433332.3_5'UTR|SRGAP3_ENST00000360413.3_Splice_Site_p.K224_splice	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	224					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCCCACTCACCTTCTCCTTCA	0.607000			T	RAF1	pilocytic astrocytoma								26	69					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30825370	30825370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30825370C>T	ENST00000383096.3	-	15	1614	c.1432G>A	c.(1432-1434)Gaa>Aaa	p.E478K	CCDC178_ENST00000402325.1_Missense_Mutation_p.E478K|CCDC178_ENST00000583930.1_Missense_Mutation_p.E478K|CCDC178_ENST00000406524.2_Missense_Mutation_p.E478K|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000579947.1_Missense_Mutation_p.E478K|CCDC178_ENST00000403303.1_Missense_Mutation_p.E478K|CCDC178_ENST00000300227.8_Missense_Mutation_p.E478K					coiled-coil domain containing 178																		ATTTCAGATTCGTATTTTGAT	0.254000													6	14					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27389935	27389935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:27389935G>A	ENST00000379214.4	-	18	2778	c.2335C>T	c.(2335-2337)Ccc>Tcc	p.P779S	LGR4_ENST00000389858.4_Missense_Mutation_p.P755S	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	779						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						ATTATTTCGGGGCTGATAGAG	0.403000													30	105					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51921502	51921502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51921502C>T	ENST00000371117.3	-	18	1962	c.1687G>A	c.(1687-1689)Gaa>Aaa	p.E563K	PKHD1_ENST00000340994.4_Missense_Mutation_p.E563K	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	563					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GCACCTCGTTCAAATCCAAGC	0.403000													34	97					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30954258	30954258	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:30954258G>A	ENST00000295055.8	-	21	2111	c.1935C>T	c.(1933-1935)ttC>ttT	p.F645F	CAPN13_ENST00000534090.2_Silent_p.F645F	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	645	EF-hand 2.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AGAGGTTGCGGAAGGTCTCTA	0.567000													8	10					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3633209	3633209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3633209G>A	ENST00000294008.3	-	14	5682	c.5042C>T	c.(5041-5043)tCg>tTg	p.S1681L	RP11-461A8.1_ENST00000573982.1_lincRNA	NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1681	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CTTGGTGGGCGACCTGCTTGG	0.602000								Direct reversal of damage					37	59					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8608525	8608525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8608525G>A	ENST00000382480.2	+	6	1357	c.557G>A	c.(556-558)cGa>cAa	p.R186Q	CPZ_ENST00000360986.4_Missense_Mutation_p.R323Q|CPZ_ENST00000429646.2_5'UTR|CPZ_ENST00000315782.6_Missense_Mutation_p.R312Q	NM_001014448.2	NP_001014448.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	323					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATCTGAACCGAAATTTCCCG	0.647000													25	53					0	0	1	0	0
PRKAR1B	5575	broad.mit.edu	37	7	751015	751015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:751015G>A	ENST00000406797.1	-	2	302	c.128C>T	c.(127-129)cCc>cTc	p.P43L	PRKAR1B_ENST00000360274.4_Missense_Mutation_p.P43L|PRKAR1B_ENST00000403562.1_Missense_Mutation_p.P43L|PRKAR1B_ENST00000488474.1_5'UTR|PRKAR1B_ENST00000537384.1_Missense_Mutation_p.P43L|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.P43L	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	43	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		GGGGCGTTCGGGCTTGGAGAT	0.632000													20	61					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92590422	92590422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92590422C>T	ENST00000298047.6	+	19	11425	c.11408C>T	c.(11407-11409)cCg>cTg	p.P3803L	FAT3_ENST00000533797.1_Missense_Mutation_p.P138L|FAT3_ENST00000409404.2_Missense_Mutation_p.P3803L|FAT3_ENST00000525166.1_Missense_Mutation_p.P3653L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3803	EGF-like 1.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGAGAAGCCGTGTCCAGGG	0.557000										TCGA Ovarian(4;0.039)			19	81					0	0	1	0	0
LOC400794	400794	broad.mit.edu	37	1	165551093	165551093	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165551093C>T	ENST00000438275.1	-	0	272				RP11-280O1.2_ENST00000421273.1_RNA|RP11-280O1.2_ENST00000416424.1_RNA																							TCTCCCTGCCCATCACGGAAT	0.557000													3	5					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367193	107367193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107367193G>A	ENST00000542196.1	-	1	758	c.716C>T	c.(715-717)tCt>tTt	p.S239F		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						TGAACAGGTAGAGGAAGCTTT	0.403000													29	64					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73617662	73617662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73617662C>T	ENST00000261917.3	-	5	2707	c.1714G>A	c.(1714-1716)Gag>Aag	p.E572K		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	572					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		TCGCTTAGCTCGCCCAGGATG	0.677000													22	79					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205132913	205132913	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205132913G>A	ENST00000367162.3	-	4	1525	c.1495C>T	c.(1495-1497)Ctg>Ttg	p.L499L	DSTYK_ENST00000367161.3_Silent_p.L499L|DSTYK_ENST00000367160.4_Intron	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	499						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						AGGCTCTGCAGACATCGTTCC	0.453000													10	42					0	0	1	0	0
ASUN	55726	broad.mit.edu	37	12	27081176	27081176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:27081176C>T	ENST00000261191.7	-	5	1082	c.546G>A	c.(544-546)acG>acA	p.T182T	ASUN_ENST00000539625.1_Silent_p.T81T	NM_018164.2	NP_060634.2	Q9NVM9	M89BB_HUMAN	asunder spermatogenesis regulator	182					cell division|mitosis|regulation of mitotic cell cycle		protein binding										GTTCATGAATCGTTTCCTGGA	0.294000													11	84					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569726	241569726	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241569726G>A	ENST00000319838.5	+	6	1299	c.357G>A	c.(355-357)cgG>cgA	p.R119R	GPR35_ENST00000438013.2_Silent_p.R150R|GPR35_ENST00000407714.1_Silent_p.R119R|GPR35_ENST00000430267.1_Silent_p.R119R|GPR35_ENST00000403859.1_Silent_p.R119R	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	119						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		TGGCCGTGCGGCACCCGCTGC	0.711000													9	24					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140416159	140416159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140416159C>T	ENST00000406427.1	-	10	1222	c.886G>A	c.(886-888)Gtg>Atg	p.V296M	PNPLA7_ENST00000277531.4_Missense_Mutation_p.V271M	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	271					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TGCAGCCGCACCATGATGATC	0.617000													14	45					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10769819	10769819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10769819C>T	ENST00000283025.2	-	5	1154	c.1083G>A	c.(1081-1083)gcG>gcA	p.A361A		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	361					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						TGCTCACCTTCGCCAGCTGCG	0.592000													9	81					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10089637	10089637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10089637C>T	ENST00000264828.3	-	40	2979	c.2894G>A	c.(2893-2895)gGa>gAa	p.G965E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	965	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CCCAAGGGGTCCTGGTGGTCC	0.637000													5	15					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33015577	33015577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:33015577C>T	ENST00000280979.4	+	4	1888	c.1718C>T	c.(1717-1719)tCc>tTc	p.S573F	AKAP6_ENST00000557272.1_Missense_Mutation_p.S573F|AKAP6_ENST00000557354.1_Missense_Mutation_p.S573F	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	573					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCAGAAACATCCAGTTCACCA	0.443000													37	93					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100680532	100680532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100680532C>T	ENST00000306151.4	+	3	5899	c.5835C>T	c.(5833-5835)acC>acT	p.T1945T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1945	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AAATCAACACCCTTTCAACAA	0.502000													146	375					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291974	33291974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:33291974G>A	ENST00000280979.4	+	13	5125	c.4955G>A	c.(4954-4956)cGa>cAa	p.R1652Q	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1652	Ser-rich.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AAGATAAAACGAAGTGTTTCT	0.423000													20	60					0	0	1	0	0
C4orf50	389197	broad.mit.edu	37	4	5961342	5961342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:5961342G>A	ENST00000531445.1	-	7	2059	c.2013C>T	c.(2011-2013)tcC>tcT	p.S671S	C4orf50_ENST00000324058.5_Silent_p.S197S			Q6ZRC1	CD050_HUMAN	chromosome 4 open reading frame 50	197										breast(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(2)|skin(3)|urinary_tract(1)	15						TGGACACCAAGGACAGAGGGA	0.527000													8	33					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835344	38835344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38835344G>A	ENST00000449082.2	-	1	157	c.158C>T	c.(157-159)cCc>cTc	p.P53L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	53					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTCCAGCTGGGGCCGAGGCTT	0.542000													61	119					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2436207	2436207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2436207G>A	ENST00000452833.1	-	10	1564	c.1556C>T	c.(1555-1557)cCc>cTc	p.P519L	TRPM5_ENST00000528453.1_Missense_Mutation_p.P517L|TRPM5_ENST00000155858.6_Missense_Mutation_p.P517L|TRPM5_ENST00000533060.1_Missense_Mutation_p.P517L			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	517						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTCCCGCCAGGGGTTCTCGCT	0.706000													7	21					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53062516	53062516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:53062516C>T	ENST00000276480.7	-	16	2511	c.1828G>A	c.(1828-1830)Gaa>Aaa	p.E610K		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	610						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GTGCCATTTTCATCCACTTCT	0.418000													36	86					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028546	37028546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37028546C>T	ENST00000358047.3	+	1	2115	c.2063C>T	c.(2062-2064)tCt>tTt	p.S688F		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	688										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						ACTCGCGTATCTCATCTCCGC	0.657000													30	28					0	0	1	0	0
TPM1	7168	broad.mit.edu	37	15	63354877	63354877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:63354877C>T	ENST00000560959.1	+	7	711	c.697C>T	c.(697-699)Ctt>Ttt	p.L233F	TPM1_ENST00000317516.7_Intron|TPM1_ENST00000334895.5_Intron|TPM1_ENST00000288398.6_Intron|TPM1_ENST00000559397.1_Intron|TPM1_ENST00000358278.3_Intron|TPM1_ENST00000403994.3_Intron|TPM1_ENST00000559556.1_Intron|TPM1_ENST00000267996.7_Intron|TPM1_ENST00000560445.1_Intron|TPM1_ENST00000357980.4_Intron|TPM1_ENST00000404484.4_Intron|TPM1_ENST00000559281.1_Intron			P09493	TPM1_HUMAN	tropomyosin 1 (alpha)	0					cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle			endometrium(1)|large_intestine(1)|lung(2)	4						TAGTTTAATCCTTATGGTTGA	0.408000													10	63					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520541	33520541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33520541G>A	ENST00000297307.5	-	1	871	c.786C>T	c.(784-786)ctC>ctT	p.L262L		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	262						integral to membrane											AGACCAAGGCGAGGATCCCCA	0.627000													29	70					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44640909	44640909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44640909G>A	ENST00000372330.3	+	7	1150	c.1131G>A	c.(1129-1131)tcG>tcA	p.S377S		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	377	Fibronectin type-II 3.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CTACCACCTCGAACTTTGACA	0.657000													39	94					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67703945	67703945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:67703945C>T	ENST00000545606.1	+	13	3646	c.3209C>T	c.(3208-3210)cCa>cTa	p.P1070L		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	1070					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GAAATGGGTCCATTTAAACAT	0.353000													21	152					0	0	1	0	0
FUT5	2527	broad.mit.edu	37	19	5867474	5867474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5867474G>A	ENST00000252675.5	-	5	825	c.263C>T	c.(262-264)cCc>cTc	p.P88L	FUT5_ENST00000588525.1_Missense_Mutation_p.P88L			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	88					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						CAGAGCCACGGGTGTGTTAAA	0.662000													9	74					0	0	1	0	0
KIAA1045	23349	broad.mit.edu	37	9	34976624	34976624	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34976624G>A	ENST00000242315.3	+	5	818	c.736G>A	c.(736-738)Gag>Aag	p.E246K	KIAA1045_ENST00000476115.2_3'UTR|KIAA1045_ENST00000544237.1_Missense_Mutation_p.E246K	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	246							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			GGAGCAAGAAGAGCAGGCGGC	0.612000													18	65					0	0	1	0	0
UBE3A	7337	broad.mit.edu	37	15	25585324	25585324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25585324G>A	ENST00000232165.3	-	12	3062	c.2406C>T	c.(2404-2406)ttC>ttT	p.F802F	UBE3A_ENST00000566215.1_Silent_p.F782F|UBE3A_ENST00000438097.1_Silent_p.F782F|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000428984.2_Silent_p.F782F|UBE3A_ENST00000397954.2_Silent_p.F805F	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	805	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TAAACTGCAAGAAGAGTCTTT	0.393000													24	98					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21750215	21750215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21750215G>A	ENST00000328843.6	+	42	6780	c.6749G>A	c.(6748-6750)cGa>cAa	p.R2250Q	DNAH11_ENST00000409508.3_Missense_Mutation_p.R2243Q			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2250	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TCCATTCTACGAGAACAAGCA	0.343000									Kartagener syndrome				9	37					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1050936	1050936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1050936C>T	ENST00000263094.6	+	19	2800	c.2569C>T	c.(2569-2571)Ctc>Ttc	p.L857F	ABCA7_ENST00000433129.1_Missense_Mutation_p.L857F|ABCA7_ENST00000435683.2_Missense_Mutation_p.L719F	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	857	ABC transporter 1.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTGAGTGGCCTCTTCCCACC	0.562000													34	69					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23855800	23855800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23855800G>A	ENST00000405093.3	-	33	4753	c.4683C>T	c.(4681-4683)ctC>ctT	p.L1561L	MYH6_ENST00000356287.3_Silent_p.L1561L	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1561					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCTGGGCCCGGAGGATCTTGC	0.642000													77	183					0	0	1	0	0
CHRM5	1133	broad.mit.edu	37	15	34356343	34356343	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34356343C>T	ENST00000383263.5	+	3	2095	c.1425C>T	c.(1423-1425)acC>acT	p.T475T	CHRM5_ENST00000557872.1_Silent_p.T475T	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	475					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	TCCCAGTCACCCTGTGGCACT	0.498000													30	72					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50759407	50759407	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50759407G>A	ENST00000300589.2	+	10	2995	c.2890G>A	c.(2890-2892)Gag>Aag	p.E964K		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	964					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				CAGCCTGGAGGAGAACCATCT	0.418000													15	52					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068442	5068442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5068442C>T	ENST00000380370.1	+	1	687	c.687C>T	c.(685-687)ctC>ctT	p.L229L		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTTCCGCCTCCCATCACATG	0.448000													72	143					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101587521	101587521	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101587521G>A	ENST00000536262.2	-	5	1132	c.574C>T	c.(574-576)Caa>Taa	p.Q192*		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	192					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ATCCCAACTTGAAAAACATCT	0.398000													26	162					0	0	1	0	0
C15orf32	145858	broad.mit.edu	37	15	93015449	93015449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93015449G>A	ENST00000333334.2	+	1	566	c.71G>A	c.(70-72)gGg>gAg	p.G24E	C15orf32_ENST00000556865.1_Missense_Mutation_p.G24E	NM_153040.2	NP_694585.1	Q32M92	CO032_HUMAN	chromosome 15 open reading frame 32	24										endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	12	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			AGTGGGGAAGGGGTCCCACCT	0.537000													20	97					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75108735	75108735	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75108735C>T	ENST00000326665.5	-	4	509	c.291G>A	c.(289-291)agG>agA	p.R97R		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	97										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTCGCTCCTTCCTAGCTAAGG	0.318000													27	77					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836667	142836667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142836667G>A	ENST00000291009.3	+	4	413	c.373G>A	c.(373-375)Gat>Aat	p.D125N		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	125						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		CATCTGCCCTGATGATGCTGC	0.473000													59	164					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220466102	220466102	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220466102C>T	ENST00000456909.1	+	3	297	c.207C>T	c.(205-207)tcC>tcT	p.S69S	STK11IP_ENST00000295641.10_Silent_p.S80S|STK11IP_ENST00000459692.1_3'UTR			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	80					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGCCGACTCCCCTGTTATTC	0.567000													16	50					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16532066	16532066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16532066G>A	ENST00000270747.3	-	9	1684	c.1548C>T	c.(1546-1548)ttC>ttT	p.F516F	ARHGEF19_ENST00000478117.1_5'UTR|ARHGEF19_ENST00000421561.1_Intron	NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	516	DH.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		TGATCCTCTGGAAGGGCAGGA	0.647000													13	28					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581366	140581366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140581366C>T	ENST00000354757.3	+	1	2019	c.2019C>T	c.(2017-2019)ctC>ctT	p.L673L	PCDHB11_ENST00000536699.1_Silent_p.L308L	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		673					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTGCCGCTCCCTGAGGCGG	0.682000													41	144					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711257	155711257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:155711257G>A	ENST00000295101.2	+	3	1415	c.938G>A	c.(937-939)cGa>cAa	p.R313Q	KCNJ3_ENST00000493505.1_3'UTR|KCNJ3_ENST00000544049.1_3'UTR	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	313					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	TGTCAAGCTCGAACATCATAT	0.358000													30	80					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	53017610	53017610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:53017610G>A	ENST00000354452.3	-	8	1140	c.529C>T	c.(529-531)Cct>Tct	p.P177S	TCF4_ENST00000570177.2_Missense_Mutation_p.P47S|TCF4_ENST00000564403.2_Missense_Mutation_p.P177S|TCF4_ENST00000564999.1_Missense_Mutation_p.P177S|TCF4_ENST00000537856.3_Missense_Mutation_p.P47S|TCF4_ENST00000564228.1_Missense_Mutation_p.P106S|TCF4_ENST00000537578.1_Missense_Mutation_p.P153S|TCF4_ENST00000568673.1_Missense_Mutation_p.P153S|TCF4_ENST00000568740.1_Missense_Mutation_p.P152S|TCF4_ENST00000544241.2_Missense_Mutation_p.P106S|TCF4_ENST00000540999.1_Missense_Mutation_p.P153S|TCF4_ENST00000356073.4_Missense_Mutation_p.P177S|TCF4_ENST00000543082.1_Missense_Mutation_p.P135S|TCF4_ENST00000567880.1_Intron|TCF4_ENST00000398339.1_Missense_Mutation_p.P279S|TCF4_ENST00000566286.1_Missense_Mutation_p.P175S|TCF4_ENST00000565018.2_Missense_Mutation_p.P177S|TCF4_ENST00000561992.1_Missense_Mutation_p.P47S|TCF4_ENST00000566279.1_Intron	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	177					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		AAACCTGGAGGAACTTTTCGA	0.363000													23	69					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103294550	103294550	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103294550G>A	ENST00000424685.2	-	13	1703	c.1544C>T	c.(1543-1545)tCc>tTc	p.S515F	RELN_ENST00000343529.5_Missense_Mutation_p.S515F|RELN_ENST00000428762.1_Missense_Mutation_p.S515F			P78509	RELN_HUMAN	reelin	515					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTTATATGAGGAATAGGAAAG	0.428000													23	64					0	0	1	0	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89916702	89916702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:89916702G>A	ENST00000548729.1	-	3	1918	c.1616C>T	c.(1615-1617)cCa>cTa	p.P539L	GALNT4_ENST00000529983.2_Missense_Mutation_p.P542L|POC1B_ENST00000541909.1_Intron|POC1B-GALNT4_ENST00000413530.1_Missense_Mutation_p.P370L|POC1B_ENST00000549504.1_Intron|POC1B_ENST00000393179.4_Intron|POC1B-GALNT4_ENST00000547474.1_3'UTR|POC1B_ENST00000549035.1_Intron|POC1B_ENST00000313546.3_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					TCCTGAGTGTGGGTGAAAAAT	0.398000													8	78					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703507	55703507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55703507G>A	ENST00000301532.3	-	1	369	c.370C>T	c.(370-372)Cgc>Tgc	p.R124C		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GCGACATAGCGATCATAGGCC	0.438000													20	69					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85997276	85997276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85997276C>T	ENST00000372105.3	-	2	310	c.289G>A	c.(289-291)Gag>Aag	p.E97K		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	97						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GCGTTGAGCTCGCTGAGGGCG	0.736000													9	14					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378801	114378801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:114378801C>T	ENST00000312719.5	-	5	1849	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K	HS3ST5_ENST00000411826.1_Missense_Mutation_p.E221K|RP3-399L15.3_ENST00000519270.1_RNA|RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	221					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		GTGTTCACTTCGCATGTATTA	0.398000													87	143					0	0	1	0	0
FAM21EP	100421577	broad.mit.edu	37	10	51818892	51818892	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:51818892G>A	ENST00000456967.1	-	0	1538					NR_038275.1																						GGGGTGTCGAGAAAAAGtcgt	0.502000													11	21					0	0	1	0	0
C11orf71	54494	broad.mit.edu	37	11	114270917	114270917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:114270917G>A	ENST00000325636.4	-	1	222	c.137C>T	c.(136-138)cCt>cTt	p.P46L	RBM7_ENST00000540163.1_5'UTR	NM_019021.2	NP_061894.2	Q6IPW1	CK071_HUMAN	chromosome 11 open reading frame 71	46										large_intestine(3)|lung(1)	4		all_cancers(61;1.15e-11)|all_epithelial(67;5.3e-06)|all_hematologic(158;0.000303)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.6e-06)|Epithelial(105;4.31e-05)|all cancers(92;0.00036)		AATCGCTTCAGGCCTGGAAAC	0.662000													8	24					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86010787	86010787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:86010787C>T	ENST00000383699.3	+	8	1587	c.960C>T	c.(958-960)ctC>ctT	p.L320L	CADM2_ENST00000407528.2_Silent_p.L311L|CADM2_ENST00000405615.2_Silent_p.L313L	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	311	Thr-rich.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AATATGTTCTCATTGTGCATG	0.348000													21	82					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77290750	77290750	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77290750C>T	ENST00000388914.3	-	10	1328	c.1176G>A	c.(1174-1176)gaG>gaA	p.E392E		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	392										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CCAGACTCAGCTCCTTCTCCC	0.443000													15	69					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345226	33345226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33345226G>A	ENST00000374796.2	-	8	3895	c.1325C>T	c.(1324-1326)tCc>tTc	p.S442F	NCOA6_ENST00000359003.2_Missense_Mutation_p.S442F			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	442	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CGTTGGGGAGGATGCAGGGGA	0.602000													31	79					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128595285	128595285	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:128595285C>T	ENST00000335251.5	+	6	1201	c.1098C>T	c.(1096-1098)tcC>tcT	p.S366S	INTU_ENST00000296461.5_Silent_p.S366S	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	366										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						TTAGTTCATCCCTCCTTTTAA	0.303000													11	46					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57714214	57714214	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57714214G>A	ENST00000333493.4	+	7	866	c.705G>A	c.(703-705)acG>acA	p.T235T	GPR97_ENST00000327655.6_Silent_p.T25T|GPR97_ENST00000450388.3_Silent_p.T115T	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	235	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GCTGCTCCACGGAGGTCAGAC	0.627000													11	51					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916456	42916456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42916456C>T	ENST00000316161.4	-	1	1177	c.853G>A	c.(853-855)Ggg>Agg	p.G285R	ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Missense_Mutation_p.G285R	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	285					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCCGTGTTCCCCTGGGAGGCC	0.582000													8	17					0	0	1	0	0
SRRM1	10250	broad.mit.edu	37	1	24989170	24989170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24989170C>T	ENST00000323848.9	+	12	1818	c.1503C>T	c.(1501-1503)tcC>tcT	p.S501S	SRRM1_ENST00000479034.1_3'UTR|SRRM1_ENST00000447431.2_Silent_p.S499S|SRRM1_ENST00000374389.4_Silent_p.S496S|SRRM1_ENST00000537199.1_3'UTR	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	501	Arg-rich.|Necessary for speckles and matrix localization.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CCTCCTCCTCCTCAGAAGATG	0.453000													14	104					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100502	93100502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:93100502G>A	ENST00000544406.2	+	2	361	c.95G>A	c.(94-96)gGg>gAg	p.G32E	C12orf74_ENST00000397833.3_Missense_Mutation_p.G32E			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	32										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						AAGAACCAGGGGAGTCTCCTC	0.597000													17	41					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84256408	84256408	+	Silent	SNP	C	C	T	rs113623603		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84256408C>T	ENST00000308251.4	-	3	1043	c.975G>A	c.(973-975)ggG>ggA	p.G325G		NM_172347.2	NP_758857.1	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	325			G -> R (in dbSNP:rs7196482).			voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GGTAGGAGCTCCCGCTCGGCC	0.672000													4	16					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565267	58565267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58565267G>A	ENST00000282326.1	+	6	1322	c.1075G>A	c.(1075-1077)Gag>Aag	p.E359K		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	359					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGGCCCCCGGGAGTCCGTCCC	0.657000													17	33					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53814059	53814059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53814059G>A	ENST00000288139.3	+	39	4772	c.4654G>A	c.(4654-4656)Gtt>Att	p.V1552I	CACNA1D_ENST00000422281.2_Missense_Mutation_p.V1517I|CACNA1D_ENST00000350061.5_Missense_Mutation_p.V1532I|CACNA1D_ENST00000540742.1_Missense_Mutation_p.V424I	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1532					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACAGAGATTAGTTGCCATGAA	0.418000													20	93					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801106	185801106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185801106C>T	ENST00000302277.6	+	4	1577	c.983C>T	c.(982-984)tCa>tTa	p.S328L		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	328						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGTCAAAATTCAGTCCCATTA	0.323000													17	45					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1437219	1437219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1437219G>A	ENST00000345913.4	+	4	280	c.189G>A	c.(187-189)aaG>aaA	p.K63K	TPO_ENST00000382269.3_Silent_p.K63K|TPO_ENST00000349624.3_Silent_p.K63K|TPO_ENST00000329066.4_Silent_p.K63K|TPO_ENST00000337415.3_Silent_p.K63K|TPO_ENST00000539820.1_Silent_p.K63K|TPO_ENST00000497517.2_Intron|TPO_ENST00000346956.3_Silent_p.K63K|TPO_ENST00000382198.1_Silent_p.K63K|TPO_ENST00000382201.3_Silent_p.K63K	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	63					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GAAACCTCAAGAAAAGAGGAA	0.363000													32	65					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373732	86373732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:86373732C>T	ENST00000604798.1	-	8	1976	c.772G>A	c.(772-774)Ggc>Agc	p.G258S	MGAT4C_ENST00000548651.1_Missense_Mutation_p.G258S|MGAT4C_ENST00000332156.1_Missense_Mutation_p.G258S|MGAT4C_ENST00000552808.2_Missense_Mutation_p.G258S|MGAT4C_ENST00000549405.2_Missense_Mutation_p.G258S|MGAT4C_ENST00000393205.2_Missense_Mutation_p.G287S|MGAT4C_ENST00000552435.2_Intron			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	258					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CCAATGTAGCCAAGCTTAGAG	0.363000													17	79					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1077677	1077677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1077677C>T	ENST00000441003.2	+	3	454	c.427C>T	c.(427-429)Ctc>Ttc	p.L143F	MUC2_ENST00000359061.5_Missense_Mutation_p.L143F	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	143	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCGCGCCGGCCTCACCCTCAT	0.672000													8	18					0	0	1	0	0
ZC4H2	55906	broad.mit.edu	37	X	64141826	64141826	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:64141826C>T	ENST00000545618.1	-	3	644	c.81G>A	c.(79-81)aaG>aaA	p.K27K	ZC4H2_ENST00000374839.3_Silent_p.K32K|ZC4H2_ENST00000447788.2_Silent_p.K32K|ZC4H2_ENST00000337990.2_Silent_p.K9K|ZC4H2_ENST00000488608.1_5'UTR			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	32							metal ion binding|protein binding	p.K32N(2)		endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CAAACTCAGCCTTCAAACGAG	0.483000													21	10					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	431895	431895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:431895C>T	ENST00000332826.6	-	6	502	c.418G>A	c.(418-420)Gat>Aat	p.D140N		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	140						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						TTCATCAGATCCTCGAAGGTC	0.677000													6	40					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65621418	65621418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65621418G>A	ENST00000327987.4	-	14	2525	c.2274C>T	c.(2272-2274)ggC>ggT	p.G758G		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	758										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCTCCATCAGGCCGCACCCCT	0.706000													11	3					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10916768	10916768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10916768C>T	ENST00000254488.2	+	6	945	c.879C>T	c.(877-879)ctC>ctT	p.L293L		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	293					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCTCCCGGCTCTCCGACCCCC	0.592000													36	60					0	0	1	0	0
RPP14	11102	broad.mit.edu	37	3	58296101	58296101	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58296101C>T	ENST00000445193.2	+	2	456	c.45C>T	c.(43-45)aaC>aaT	p.N15N	RPP14_ENST00000466547.1_Silent_p.N15N|RPP14_ENST00000295959.5_Silent_p.N15N|RPP14_ENST00000544156.1_5'UTR|RPP14_ENST00000477305.1_Intron	NM_001098783.2	NP_001092253.1	O95059	RPP14_HUMAN	ribonuclease P/MRP 14kDa subunit	15					tRNA processing	nucleus	identical protein binding|ribonuclease P activity|RNA binding			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.000187)|KIRC - Kidney renal clear cell carcinoma(10;0.0102)|Kidney(10;0.0118)|OV - Ovarian serous cystadenocarcinoma(275;0.191)		TTTACAAAAACCCTTCCGAGT	0.383000													27	76					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3673354	3673354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3673354G>A	ENST00000294600.2	+	4	695	c.611G>A	c.(610-612)aGa>aAa	p.R204K		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	204								p.R204I(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CGGAAGAGGAGAAAATCCCAG	0.547000													21	73					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113235516	113235516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113235516C>T	ENST00000369644.1	+	8	1966	c.937C>T	c.(937-939)Cct>Tct	p.P313S	MOV10_ENST00000413052.2_Missense_Mutation_p.P369S|MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000357443.2_Missense_Mutation_p.P369S|MOV10_ENST00000369645.1_Missense_Mutation_p.P369S			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	369					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GACCTGGGACCCTGTGGACCA	0.612000													7	21					0	0	1	0	0
SLC7A4	6545	broad.mit.edu	37	22	21385560	21385560	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21385560G>A	ENST00000382932.2	-	2	609	c.542C>T	c.(541-543)tCt>tTt	p.S181F	SLC7A4_ENST00000403586.1_Missense_Mutation_p.S181F	NM_004173.2	NP_004164.2	O43246	CTR4_HUMAN	solute carrier family 7, member 4	181				THVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSS -> DPRGFLAGAPPGPLPGLPGCWHHPPWPLPLSPVEPACPP (in Ref. 1; CAA04263).	cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(2)	18	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GACAAAGGCAGAGGCCAGGAG	0.597000													18	28					0	0	1	0	0
MXRA8	54587	broad.mit.edu	37	1	1290116	1290116	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1290116G>C	ENST00000309212.6	-	5	925	c.895C>G	c.(895-897)Ccc>Gcc	p.P299A	MXRA8_ENST00000445648.2_Missense_Mutation_p.P299A|MXRA8_ENST00000342753.4_Missense_Mutation_p.P198A	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	299						integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCCCGGGGGGGCGGCTCCGCG	0.731000													7	20					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122757604	122757604	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122757604G>A	ENST00000194130.2	-	14	1610	c.1571C>T	c.(1570-1572)tCa>tTa	p.S524L	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	524						integral to membrane|plasma membrane	sodium:sulfate symporter activity	p.S524L(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	GAATGCAAATGAAGTACACAG	0.368000													30	67					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714929	92714929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92714929C>T	ENST00000257068.2	+	2	546	c.540C>T	c.(538-540)tcC>tcT	p.S180S		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	180					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	TTGTGGGGTCCCTGGAGTACG	0.612000													9	62					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47401236	47401236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47401236C>T	ENST00000310638.4	-	5	625	c.594G>A	c.(592-594)atG>atA	p.M198I	CYP4A11_ENST00000371904.4_Missense_Mutation_p.M198I|CYP4A11_ENST00000457840.2_Missense_Mutation_p.M94I|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371905.1_Missense_Mutation_p.M198I	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	198					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	AGGCACACTTCATGATGGTGT	0.572000													28	89					0	0	1	0	0
WBP1L	54838	broad.mit.edu	37	10	104572539	104572539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104572539C>T	ENST00000369889.4	+	4	622	c.480C>T	c.(478-480)ccC>ccT	p.P160P	WBP1L_ENST00000448841.1_Silent_p.P181P	NM_017787.4	NP_060257.4	Q9NX94	OPA1L_HUMAN	WW domain binding protein 1-like	160	Pro-rich.					integral to membrane											AGAGCAGCCCCTTGTCTGAGC	0.647000													25	32					0	0	1	0	0
IGLV11-55	28770	broad.mit.edu	37	22	22556304	22556304	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22556304C>T	ENST00000390286.2	+	0	130																											AGCCAGACTCCCCTGCACCCT	0.582000											OREG0026354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	55					0	0	1	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239242627	239242627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239242627G>A	ENST00000373327.4	+	7	1236	c.1014G>A	c.(1012-1014)aaG>aaA	p.K338K	TRAF3IP1_ENST00000391994.2_Silent_p.K338K|TRAF3IP1_ENST00000391993.3_Silent_p.K338K	NM_015650.3	NP_056465.2	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting protein 1	338	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(2)	23		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		GAGCTTCCAAGTCATTGACAA	0.299000													6	29					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587557	55587557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55587557C>T	ENST00000333976.4	+	1	472	c.452C>T	c.(451-453)gCc>gTc	p.A151V		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				GGATCCTATGCCTGGGGAGTC	0.478000													23	167					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102490132	102490132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102490132C>T	ENST00000413150.2	+	21	2341	c.2286C>T	c.(2284-2286)ctC>ctT	p.L762L	MAP4K4_ENST00000350878.4_Silent_p.L887L|MAP4K4_ENST00000324219.4_Silent_p.L928L|MAP4K4_ENST00000425019.1_Silent_p.L880L|MAP4K4_ENST00000456652.1_Silent_p.L646L|MAP4K4_ENST00000347699.4_Silent_p.L847L|MAP4K4_ENST00000302217.5_Silent_p.L650L|MAP4K4_ENST00000350198.4_Silent_p.L766L	NM_001242560.1|NM_004834.4	NP_001229489.1|NP_004825.3	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	847					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GTAGCACACTCCAGAAACACA	0.363000													6	24					0	0	1	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81443974	81443974	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81443974G>A	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							CTACGGGGACGGCGGCAAGCA	0.632000													4	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179633472	179633472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179633472G>A	ENST00000589042.1	-	38	9315	c.9091C>T	c.(9091-9093)Cac>Tac	p.H3031Y	TTN_ENST00000342992.6_Missense_Mutation_p.H3031Y|TTN_ENST00000360870.5_Missense_Mutation_p.H3031Y|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.H2985Y|TTN_ENST00000342175.6_Missense_Mutation_p.H2985Y|TTN_ENST00000359218.5_Missense_Mutation_p.H2985Y|TTN_ENST00000591111.1_Missense_Mutation_p.H3031Y	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2770	Ig-like 17.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCCAAAGTGAACATTCCTG	0.408000													17	62					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170819401	170819401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170819401C>T	ENST00000436636.2	-	22	2772	c.2428G>A	c.(2428-2430)Gaa>Aaa	p.E810K	TNIK_ENST00000460047.1_Missense_Mutation_p.E747K|TNIK_ENST00000538048.1_Missense_Mutation_p.E762K|TNIK_ENST00000369326.5_Missense_Mutation_p.E788K|TNIK_ENST00000284483.8_Missense_Mutation_p.E802K|TNIK_ENST00000470834.1_Missense_Mutation_p.E773K|TNIK_ENST00000357327.5_Missense_Mutation_p.E781K|TNIK_ENST00000488470.1_Missense_Mutation_p.E755K|TNIK_ENST00000475336.1_Missense_Mutation_p.E718K|TNIK_ENST00000341852.6_Missense_Mutation_p.E726K	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	810	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TCTCTTAGTTCTTTGGCTAAT	0.453000													25	66					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82764008	82764008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82764008C>T	ENST00000423517.2	-	3	3195	c.2858G>A	c.(2857-2859)gGa>gAa	p.G953E	PCLO_ENST00000333891.8_Missense_Mutation_p.G953E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	899	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGAATGAGGTCCAGGTTGGCC	0.522000													11	26					0	0	1	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94335415	94335415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94335415G>A	ENST00000436063.2	-	7	2320	c.2263C>T	c.(2263-2265)Cgc>Tgc	p.R755C		NM_014597.4	NP_055412.2	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 2	755					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	38		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TCTTAATTGCGAAATTTCTTC	0.323000													14	34					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56388020	56388020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56388020G>A	ENST00000355701.3	-	20	4422	c.3552C>T	c.(3550-3552)ccC>ccT	p.P1184P	BZRAP1_ENST00000268893.6_Silent_p.P1124P|BZRAP1_ENST00000343736.4_Silent_p.P1184P	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1184						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGGCCAGTGAGGGAGCTGCGG	0.672000													8	24					0	0	1	0	0
ADAMTSL5	339366	broad.mit.edu	37	19	1506656	1506656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1506656G>A	ENST00000330475.4	-	11	1490	c.1047C>T	c.(1045-1047)ccC>ccT	p.P349P	ADAMTSL5_ENST00000590562.1_5'UTR|ADAMTSL5_ENST00000413997.2_Silent_p.P359P|ADAMTSL5_ENST00000395467.2_Intron	NM_213604.2	NP_998769.2	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5	349						proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGTGGGCAGGGGTCTGTGG	0.682000													5	5					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169842719	169842719	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169842719G>A	ENST00000263817.6	-	10	1108	c.984C>T	c.(982-984)ttC>ttT	p.F328F		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	328	ABC transmembrane type-1 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GACACCACACGAATCCAGTAA	0.453000													34	76					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59112786	59112786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:59112786C>T	ENST00000395153.3	+	4	1481	c.1334C>T	c.(1333-1335)tCa>tTa	p.S445L	DACT1_ENST00000335867.4_Missense_Mutation_p.S482L|DACT1_ENST00000556859.1_Missense_Mutation_p.S201L|DACT1_ENST00000395151.3_Missense_Mutation_p.S201L|DACT1_ENST00000541264.2_Missense_Mutation_p.S201L	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	482					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						GCTCAGCTCTCAGGGGCCTCT	0.567000													42	106					0	0	1	0	0
IGLV1-44	28823	broad.mit.edu	37	22	22735275	22735275	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22735275C>T	ENST00000390297.2	+	0	141																											TCCTCCTCACCCTCCTCACTC	0.577000													5	11					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115806300	115806300	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:115806300T>C	ENST00000374227.3	-	4	625	c.598A>G	c.(598-600)Agg>Ggg	p.R200G	ZFP37_ENST00000555206.1_Missense_Mutation_p.R201G|ZFP37_ENST00000553380.1_Missense_Mutation_p.R215G			Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	200						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						TCAGATTTCCTTTTTACACAG	0.328000													51	96					0	0	1	0	0
IQSEC1	9922	broad.mit.edu	37	3	12983267	12983267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12983267G>A	ENST00000273221.4	-	2	380	c.164C>T	c.(163-165)cCg>cTg	p.P55L	IQSEC1_ENST00000473088.1_5'UTR	NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	55					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GTAGTGATCCGGGCTCAGGCT	0.697000													9	24					0	0	1	0	0
HAUS1	115106	broad.mit.edu	37	18	43698189	43698189	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43698189C>T	ENST00000282058.6	+	3	328	c.248C>T	c.(247-249)tCc>tTc	p.S83F	HAUS1_ENST00000585518.1_Intron|HAUS1_ENST00000588704.1_3'UTR	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	83					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						GTGAATTTTTCCCCCGCCAAT	0.418000													35	107					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578782	9578782	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9578782G>A	ENST00000301480.4	-	10	1054	c.841C>T	c.(841-843)Cag>Tag	p.Q281*		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						CTCTGGACCTGAACATTTAAA	0.383000													40	98					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33521168	33521168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33521168G>A	ENST00000297307.5	-	1	244	c.159C>T	c.(157-159)ttC>ttT	p.F53F		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	53	DUF6 1.					integral to membrane		p.F53F(1)									GGGGGCCCACGAAGCCAGCAG	0.667000													30	38					0	0	1	0	0
MOS	4342	broad.mit.edu	37	8	57026495	57026495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57026495G>A	ENST00000311923.1	-	1	46	c.47C>T	c.(46-48)tCc>tTc	p.S16F		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog	16							ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			CACCGATGGGGAAAACTCGCT	0.692000													11	31					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62740234	62740234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62740234C>T	ENST00000371153.4	-	3	920	c.542G>A	c.(541-543)aGc>aAc	p.S181N	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	181										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GGGCCCCAGGCTCAGGCCTGG	0.637000													4	33					0	0	1	0	0
CYP4V2	285440	broad.mit.edu	37	4	187118158	187118158	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187118158G>A	ENST00000378802.4	+	4	782	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K		NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	160					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		TACCATTCTGGAAGATTTCTT	0.308000													27	71					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332734	22332734	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22332734G>A	ENST00000558896.1	+	0	541																											CACTTTCTAGGAGCCAGTGAG	0.473000													9	39					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166229797	166229797	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166229797C>T	ENST00000375437.2	+	21	4202	c.3912C>T	c.(3910-3912)tcC>tcT	p.S1304S	SCN2A_ENST00000375427.2_Silent_p.S1304S|SCN2A_ENST00000357398.3_Silent_p.S1304S|SCN2A_ENST00000283256.6_Silent_p.S1304S	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1304					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.S1304S(2)		NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CCATCAAATCCCTCAGAACAC	0.408000													29	125					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6833919	6833919	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6833919G>A	ENST00000304076.2	+	19	1826	c.1731_splice	c.e19-1	p.D578_splice	VAV1_ENST00000539284.1_Splice_Site_p.D481_splice|VAV1_ENST00000602142.1_Splice_Site_p.D578_splice|VAV1_ENST00000599806.1_Splice_Site_p.D523_splice|VAV1_ENST00000596764.1_Splice_Site_p.D546_splice	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	578					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CTCCTTCCAGGACAAACTACA	0.537000													31	79					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169201675	169201675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169201675C>T	ENST00000393743.3	-	14	2080	c.1789G>A	c.(1789-1791)Gaa>Aaa	p.E597K		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	597							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TTTTGCTCTTCCTTTTGTTCT	0.363000													16	51					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59210841	59210841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59210841G>A	ENST00000302030.2	+	1	225	c.200G>A	c.(199-201)aGc>aAc	p.S67N		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S67I(1)		central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						TTCTTCCTAAGCAACTTATCT	0.483000													56	150					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28127349	28127349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28127349G>A	ENST00000316334.3	-	8	1903	c.1774C>T	c.(1774-1776)Ccc>Tcc	p.P592S		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	592							zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CAGTACCTGGGAAGCCCAAGC	0.473000													9	86					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1047173	1047173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1047173C>T	ENST00000263094.6	+	15	2094	c.1863C>T	c.(1861-1863)ccC>ccT	p.P621P	ABCA7_ENST00000533574.1_3'UTR|ABCA7_ENST00000433129.1_Silent_p.P621P|ABCA7_ENST00000435683.2_Silent_p.P483P	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	621					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACATCCTCCCCTACAGCCACC	0.677000													5	14					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39879646	39879646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39879646G>A	ENST00000260356.5	+	8	1384	c.1219G>A	c.(1219-1221)Gat>Aat	p.D407N		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	407	TSP type-1 1.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CCGCTCCTGCGATAGCCTCAA	0.587000													13	30					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2546846	2546846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2546846C>T	ENST00000567020.1	+	2	837	c.697C>T	c.(697-699)Ctg>Ttg	p.L233L	RP11-20I23.1_ENST00000564543.1_Silent_p.L233L|TBC1D24_ENST00000434757.2_Silent_p.L233L|TBC1D24_ENST00000293970.5_Silent_p.L233L	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	233	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						TGACGTCTTCCTGGTGGAGGG	0.642000													12	51					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299274	58299274	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58299274G>T	ENST00000377918.3	+	4	3352	c.3326G>T	c.(3325-3327)cGg>cTg	p.R1109L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1109					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGAGCCAGCCGGGATTCCAGT	0.517000													45	171					3.54561e-26	3.56936e-26	1	1	0
LRRK1	79705	broad.mit.edu	37	15	101565044	101565044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101565044G>A	ENST00000284395.5	+	17	2495	c.2095G>A	c.(2095-2097)Gga>Aga	p.G699R	LRRK1_ENST00000388948.3_Missense_Mutation_p.G702R			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	702	Roc.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGACATCGGGGGACCGGCCAG	0.582000													38	213					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27458257	27458257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27458257C>T	ENST00000264705.4	+	24	4093	c.3931C>T	c.(3931-3933)Ccc>Tcc	p.P1311S	CAD_ENST00000403525.1_Missense_Mutation_p.P1248S	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1311	CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CTTTAAGATCCCCAAGAAGAA	0.572000													14	108					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27411786	27411786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27411786G>A	ENST00000326799.3	-	12	1538	c.1390C>T	c.(1390-1392)Ctt>Ttt	p.L464F	YME1L1_ENST00000375972.3_Missense_Mutation_p.L374F|YME1L1_ENST00000376016.3_Missense_Mutation_p.L407F	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	464					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						ATTTCAGCAAGAAGTTGATTT	0.343000													30	66					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92734303	92734303	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92734303C>A	ENST00000379958.2	-	3	1377	c.1108G>T	c.(1108-1110)Gca>Tca	p.A370S		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	370						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTGGACTCTGCCAGTGTTTTA	0.338000													12	63					2.80697e-09	2.8178e-09	1	1	0
THBS1	7057	broad.mit.edu	37	15	39880361	39880361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39880361G>A	ENST00000260356.5	+	9	1578	c.1413G>A	c.(1411-1413)ggG>ggA	p.G471G		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	471	TSP type-1 2.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	AGATGAACGGGAAACCCTGTG	0.597000													10	93					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189869062	189869062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189869062G>A	ENST00000304636.3	+	40	3073	c.2903G>A	c.(2902-2904)aGg>aAg	p.R968K	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	968	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCAGGTCCTAGGGGAAGCCCT	0.522000													3	7					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8873709	8873709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:8873709G>A	ENST00000256707.3	-	29	4099	c.3918C>T	c.(3916-3918)cgC>cgT	p.R1306R	KIDINS220_ENST00000418530.1_Silent_p.R1207R|KIDINS220_ENST00000473731.1_Silent_p.R1287R|KIDINS220_ENST00000427284.1_Silent_p.R1287R	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1306					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GGGAAGCGCGGCGAGCAGGCT	0.597000													34	73					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64606904	64606904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64606904C>T	ENST00000498707.1	-	19	3041	c.2699G>A	c.(2698-2700)cGa>cAa	p.R900Q	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.R872Q	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	900	TSP type-1 2.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		AACAAGTTTTCGTTTCCGTTC	0.423000													12	26					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49210260	49210260	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:49210260G>A	ENST00000406846.2	-	7	689	c.570C>T	c.(568-570)ttC>ttT	p.F190F	FSHR_ENST00000541117.1_5'UTR|FSHR_ENST00000469138.1_5'UTR|FSHR_ENST00000304421.4_Silent_p.F164F|FSHR_ENST00000346173.3_Silent_p.F190F	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	190					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GGGTTCCATTGAATGCACAGT	0.373000									Gonadal Dysgenesis, 46 XX				14	57					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175049404	175049404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175049404C>T	ENST00000239462.4	+	4	1003	c.890C>T	c.(889-891)cCc>cTc	p.P297L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	297	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGCTACTACCCCCTGGGGAAG	0.577000													9	84					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52967192	52967192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52967192G>A	ENST00000549343.1	-	1	408	c.370C>T	c.(370-372)Ccc>Tcc	p.P124S	KRT74_ENST00000305620.2_Missense_Mutation_p.P124S			Q7RTS7	K2C74_HUMAN	keratin 74	124	Head.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		ACGTTGAGGGGGGCCAAGAGG	0.592000													21	122					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24581181	24581181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24581181C>T	ENST00000535378.1	-	8	1867	c.1225G>A	c.(1225-1227)Gga>Aga	p.G409R	KIAA0319_ENST00000378214.3_Missense_Mutation_p.G418R|KIAA0319_ENST00000430948.2_Missense_Mutation_p.G373R|KIAA0319_ENST00000543707.1_Missense_Mutation_p.G418R|KIAA0319_ENST00000537886.1_Missense_Mutation_p.G418R	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	418	PKD 1.				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						TTGACAAATCCTTCTCCAAAG	0.393000											OREG0017229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	140					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39134430	39134430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39134430G>A	ENST00000351578.6	-	9	1887	c.1697C>T	c.(1696-1698)gCt>gTt	p.A566V	FYB_ENST00000515010.1_Missense_Mutation_p.A566V|FYB_ENST00000505428.1_Missense_Mutation_p.A566V|FYB_ENST00000540520.1_Missense_Mutation_p.A576V|FYB_ENST00000512982.1_Missense_Mutation_p.A566V	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	566	SH3.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			AATCTCTACAGCAGTTGTTTT	0.323000													14	40					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130682871	130682871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130682871C>T	ENST00000510168.1	+	13	1506	c.956C>T	c.(955-957)gCt>gTt	p.A319V	ATP2C1_ENST00000504948.1_Missense_Mutation_p.A303V|ATP2C1_ENST00000504381.1_Missense_Mutation_p.A264V|ATP2C1_ENST00000533801.2_Missense_Mutation_p.A314V|ATP2C1_ENST00000505330.1_Missense_Mutation_p.A303V|ATP2C1_ENST00000428331.2_Missense_Mutation_p.A319V|ATP2C1_ENST00000507488.2_Missense_Mutation_p.A303V|ATP2C1_ENST00000508532.1_Missense_Mutation_p.A319V|ATP2C1_ENST00000393221.4_Missense_Mutation_p.A353V|ATP2C1_ENST00000359644.3_Missense_Mutation_p.A319V|ATP2C1_ENST00000328560.8_Missense_Mutation_p.A319V|ATP2C1_ENST00000422190.2_Missense_Mutation_p.A319V|ATP2C1_ENST00000513801.1_Missense_Mutation_p.A303V			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	319					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	GTGACGCTAGCTCTTGGTGTT	0.403000									Hailey-Hailey disease				70	150					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563283	140563283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140563283C>T	ENST00000361016.2	+	1	2304	c.1149C>T	c.(1147-1149)tcC>tcT	p.S383S		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		383	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGACGATTTCCTCCATCCAGG	0.483000													15	95					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89531449	89531449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:89531449G>A	ENST00000329758.1	-	8	1536	c.1208C>T	c.(1207-1209)cCa>cTa	p.P403L	TRIM49_ENST00000532501.2_Missense_Mutation_p.P326L	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	403	B30.2/SPRY.					intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GGTAGGTTTTGGGATATATTG	0.423000													13	115					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25440076	25440076	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25440076G>A	ENST00000424208.1	+	0	1460				SNORD115-14_ENST00000363090.1_RNA|SNHG14_ENST00000456576.1_RNA	NR_003305.1																						TTGGGTCGATGATGAGAAACT	0.522000													108	249					0	0	1	0	0
ZNF100	163227	broad.mit.edu	37	19	21910476	21910476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21910476G>A	ENST00000358296.6	-	5	836	c.638C>T	c.(637-639)tCa>tTa	p.S213L	ZNF100_ENST00000305570.6_Missense_Mutation_p.S149L	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						CATGCAAAATGATTTTTCACA	0.308000													23	58					0	0	1	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565296	18565296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18565296G>A	ENST00000545289.1	-	5	1773	c.1523C>T	c.(1522-1524)tCa>tTa	p.S508L		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						GATGAGAGATGAACTGCACTT	0.363000													18	27					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15758113	15758113	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15758113T>A	ENST00000221307.7	+	5	552	c.504T>A	c.(502-504)aaT>aaA	p.N168K	CYP4F3_ENST00000591058.1_Missense_Mutation_p.N168K|CYP4F3_ENST00000585846.1_Missense_Mutation_p.N168K|CYP4F3_ENST00000586182.1_Missense_Mutation_p.N168K	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	168					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						AGATTTTCAATGAGAGTGTGA	0.507000													24	167					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6222303	6222303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6222303C>T	ENST00000264870.3	-	8	1340	c.1075G>A	c.(1075-1077)Ggg>Agg	p.G359R		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	359					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TTCACGTTCCCATCTTCTTCC	0.393000													20	48					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113704124	113704124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113704124G>A	ENST00000374431.3	-	4	753	c.370C>T	c.(370-372)Cgt>Tgt	p.R124C	LPAR1_ENST00000541779.1_Missense_Mutation_p.R125C|LPAR1_ENST00000358883.4_Missense_Mutation_p.R124C|LPAR1_ENST00000538760.1_Missense_Mutation_p.R125C|LPAR1_ENST00000374430.2_Missense_Mutation_p.R124C	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	124					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						AGGCCCTGACGAAGGAGCCAT	0.527000													36	109					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26517895	26517895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26517895C>T	ENST00000456354.2	+	2	398	c.331C>T	c.(331-333)Ctc>Ttc	p.L111F		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	111					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CACCATCGCTCTCCGTACCAA	0.597000													17	40					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209784817	209784817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209784817G>A	ENST00000009105.1	+	10	1080	c.835G>A	c.(835-837)Gga>Aga	p.G279R	CAMK1G_ENST00000361322.2_Missense_Mutation_p.G279R|CAMK1G_ENST00000494990.1_3'UTR			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	279	Autoinhibitory domain (By similarity).					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		CAGGATTGACGGAAACACAGC	0.562000													5	24					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532013	84532013	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84532013C>T	ENST00000527857.1	+	0	2035					NR_026851.1																						GAAAGTCTTTCAAGGTCCATG	0.463000													12	56					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114154814	114154814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:114154814C>T	ENST00000393081.1	+	2	417	c.110C>T	c.(109-111)cCc>cTc	p.P37L	ACSL5_ENST00000354273.4_Missense_Mutation_p.P37L|ACSL5_ENST00000433418.1_Missense_Mutation_p.P37L|ACSL5_ENST00000356116.1_Missense_Mutation_p.P93L|ACSL5_ENST00000354655.4_Missense_Mutation_p.P37L|ACSL5_ENST00000479936.1_3'UTR	NM_203380.1	NP_976314.1	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	37					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		AGACCTCAACCCGTCTTACCT	0.448000													31	91					0	0	1	0	0
CD38	952	broad.mit.edu	37	4	15780251	15780251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:15780251G>A	ENST00000226279.2	+	1	351	c.214G>A	c.(214-216)Gaa>Aaa	p.E72K		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	72					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						CAAGTACACTGAAATTCATCC	0.692000													22	37					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55501474	55501474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55501474C>T	ENST00000543010.1	+	9	2594	c.2451C>T	c.(2449-2451)aaC>aaT	p.N817N	NLRP2_ENST00000263437.6_Silent_p.N814N|NLRP2_ENST00000537859.1_Silent_p.N795N|NLRP2_ENST00000391721.4_Silent_p.N793N|NLRP2_ENST00000448584.2_Silent_p.N817N|NLRP2_ENST00000339757.7_Silent_p.N795N|NLRP2_ENST00000538819.1_Silent_p.N793N|NLRP2_ENST00000427260.2_Silent_p.N794N	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	817					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CGTGCGTAAACCTCTCCGACA	0.522000													35	79					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12225854	12225854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12225854C>T	ENST00000256194.4	+	4	610	c.322C>T	c.(322-324)Ctg>Ttg	p.L108L	MICAL2_ENST00000527546.1_Silent_p.L108L|MICAL2_ENST00000342902.5_Silent_p.L108L|MICAL2_ENST00000537344.1_Silent_p.L108L|MICAL2_ENST00000527195.1_3'UTR|MICAL2_ENST00000379612.3_Silent_p.L108L	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	108						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		ACTTGCCTACCTGGGAGCCAA	0.572000													10	57					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12184911	12184911	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12184911T>A	ENST00000439326.3	+	2	244	c.69T>A	c.(67-69)ccT>ccA	p.P23P	ZNF844_ENST00000441304.2_Silent_p.P23P	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	23	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TGCTGGATCCTTCCCAGAAGA	0.493000													41	103					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45355503	45355503	+	Splice_Site	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45355503T>G	ENST00000359271.2	+	3	1539	c.1288_splice	c.e3-1	p.V430_splice		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	430						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				CCCACCCTAGTGACCTGGCTT	0.577000													28	131					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83675644	83675644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83675644G>A	ENST00000265362.3	-	6	977	c.663C>T	c.(661-663)ctC>ctT	p.L221L	SEMA3A_ENST00000436949.1_Silent_p.L221L	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	221	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						ACCTACCATTGAGCCACCTGG	0.423000													53	113					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8167710	8167710	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:8167710G>A	ENST00000402384.3	-	13	1389	c.1123C>T	c.(1123-1125)Ctg>Ttg	p.L375L	ICA1_ENST00000406470.2_Silent_p.L375L|ICA1_ENST00000265577.7_Silent_p.L374L|ICA1_ENST00000396675.3_Silent_p.L375L|ICA1_ENST00000422063.2_Silent_p.L404L|ICA1_ENST00000401396.1_Silent_p.L363L			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	375					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TCACTCAACAGCAGCAGGTCA	0.552000													33	170					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	63963095	63963095	+	Nonsense_Mutation	SNP	G	G	A	rs2942671		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:63963095G>A	ENST00000324472.4	-	21	2218	c.2035C>T	c.(2035-2037)Cga>Tga	p.R679*	DPY19L2_ENST00000413230.2_Nonsense_Mutation_p.R126*	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	679					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		GCAGATTTTCGACTATATGTA	0.264000													31	102					0	0	1	0	0
HSFY1P1	27437	broad.mit.edu	37	22	17308721	17308721	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17308721C>T	ENST00000425038.1	+	0	358					NR_003607.1																						CAATTCAAGTCTAATTCATAG	0.318000													7	24					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129030435	129030435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:129030435C>T	ENST00000274487.4	+	19	2968	c.2823C>T	c.(2821-2823)tcC>tcT	p.S941S	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	941	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CAACAGTGTCCTGCACAAAAA	0.348000													22	72					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77476765	77476765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77476765G>A	ENST00000296043.6	+	2	1125	c.172G>A	c.(172-174)Gaa>Aaa	p.E58K		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	58	PDZ.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			CAAGCAGGTCGAAGAAGGGGG	0.602000													14	44					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141740591	141740591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141740591C>T	ENST00000475668.2	+	21	2497	c.2443C>T	c.(2443-2445)Ctt>Ttt	p.L815F	MGAM_ENST00000549489.2_Missense_Mutation_p.L815F			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	815	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGGACTTCACCTTCGAGGAGG	0.478000													16	38					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637506	248637506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248637506C>T	ENST00000359594.2	+	1	880	c.855C>T	c.(853-855)atC>atT	p.I285I		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTACACCATCTTCACTCCTG	0.502000													69	322					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38620858	38620858	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38620858C>T	ENST00000413689.1	-	18	3550	c.3357G>A	c.(3355-3357)tgG>tgA	p.W1119*	SCN5A_ENST00000423572.2_Nonsense_Mutation_p.W1118*|SCN5A_ENST00000425664.1_Nonsense_Mutation_p.W1119*|SCN5A_ENST00000455624.2_Nonsense_Mutation_p.W1118*|SCN5A_ENST00000450102.2_Intron|SCN5A_ENST00000449557.2_Intron|SCN5A_ENST00000414099.2_Nonsense_Mutation_p.W1119*|SCN5A_ENST00000451551.2_Intron|SCN5A_ENST00000333535.4_Nonsense_Mutation_p.W1119*|SCN5A_ENST00000443581.1_Nonsense_Mutation_p.W1118*	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1119					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTTCCGCTTTCCACTGCTGCC	0.662000													3	12					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43547288	43547288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43547288G>A	ENST00000400427.1	+	18	4030	c.3634G>A	c.(3634-3636)Gag>Aag	p.E1212K	UMODL1_ENST00000400424.1_Missense_Mutation_p.E1084K|UMODL1_ENST00000400423.2_3'UTR|UMODL1_ENST00000408910.2_Missense_Mutation_p.E1156K|UMODL1_ENST00000408989.2_Missense_Mutation_p.E1284K	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	1156	ZP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						GGTCCTGACGGAGTGCTGGGC	0.567000													31	64					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803596	185803596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185803596G>A	ENST00000302277.6	+	4	4067	c.3473G>A	c.(3472-3474)gGg>gAg	p.G1158E		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1158						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CTTTGTCCTGGGAACCAGCCA	0.512000													60	131					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18715720	18715720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18715720C>T	ENST00000433979.1	+	26	3667	c.3551C>T	c.(3550-3552)cCt>cTt	p.P1184L	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.P1184L|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.P1225L	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1184					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GCCATAAGCCCTGCCAAATCT	0.393000													4	14					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10942755	10942755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10942755C>T	ENST00000298232.7	-	12	999	c.632G>A	c.(631-633)cGa>cAa	p.R211Q	TPTE_ENST00000361285.4_Missense_Mutation_p.R229Q|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.R191Q	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	229					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCTTGTGTATCGCCTTTTGTT	0.323000													65	441					0	0	1	0	0
SF3A1	10291	broad.mit.edu	37	22	30742459	30742459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30742459G>A	ENST00000439242.1	-	3	366	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	SF3A1_ENST00000215793.7_Missense_Mutation_p.P79S	NM_001005409.1	NP_001005409.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	79					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						TTGAACTTGGGGTTGTTGATC	0.517000													38	115					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6731105	6731105	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6731105G>A	ENST00000264080.7	-	17	1478	c.1452C>T	c.(1450-1452)tcC>tcT	p.S484S	GPR108_ENST00000598626.1_Intron|GPR108_ENST00000430424.4_Silent_p.S242S	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	484						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						AGGCCAGGGTGGAGCCCTCCA	0.697000													13	31					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40313113	40313113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40313113C>T	ENST00000263791.5	+	31	4230	c.4187C>T	c.(4186-4188)tCt>tTt	p.S1396F	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.S1368F	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1396	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		ACAATAAGCTCTTGTGACCTC	0.507000													27	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604474	179604474	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179604474G>A	ENST00000589042.1	-	48	13710	c.13486C>T	c.(13486-13488)Cag>Tag	p.Q4496*	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.Q4133*|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.Q4325*|TTN_ENST00000359218.5_Nonsense_Mutation_p.Q4258*|TTN_ENST00000591111.1_Nonsense_Mutation_p.Q4179*|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4179	Ig-like 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCCTTGCTGAATTCTAGGA	0.383000													86	191					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48452052	48452052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48452052G>A	ENST00000435803.1	+	41	12355	c.12331G>A	c.(12331-12333)Gag>Aag	p.E4111K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4111					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CAGTGGAAGTGAGCTGACCTA	0.493000													18	44					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55406589	55406589	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55406589A>T	ENST00000398661.2	-	4	456	c.325T>A	c.(325-327)Tcc>Acc	p.S109T	HMGCLL1_ENST00000428842.1_Missense_Mutation_p.S79T|HMGCLL1_ENST00000370850.2_Missense_Mutation_p.S79T|HMGCLL1_ENST00000508459.1_Missense_Mutation_p.S79T|HMGCLL1_ENST00000274901.4_Missense_Mutation_p.S79T|HMGCLL1_ENST00000308161.4_Missense_Mutation_p.S79T	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	109							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCAGTTTGGGAAAGTCGATTG	0.313000													42	82					0	0	1	0	0
HMGB1P5	10354	broad.mit.edu	37	3	22424080	22424080	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:22424080C>T	ENST00000451497.1	+	0	645																											TGTACAGTGTCTTTTTTTGTA	0.363000													10	22					0	0	1	0	0
KAT8	84148	broad.mit.edu	37	16	31131550	31131550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31131550C>T	ENST00000543774.2	+	3	590	c.255C>T	c.(253-255)ggC>ggT	p.G85G	KAT8_ENST00000448516.2_Silent_p.G85G|KAT8_ENST00000219797.4_Silent_p.G85G			Q9H7Z6	MYST1_HUMAN	K(lysine) acetyltransferase 8	85	Chromo.				histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding										ACCAGGAGGGCCGAGAGGAAT	0.547000													41	105					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17592160	17592160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17592160C>T	ENST00000375460.3	+	4	393	c.353C>T	c.(352-354)tCt>tTt	p.S118F		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	118					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GCAGACATCTCTCTGGATTGC	0.567000													40	84					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74044075	74044075	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74044075G>A	ENST00000409561.1	+	3	2846	c.2725G>A	c.(2725-2727)Gaa>Aaa	p.E909K		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	909										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						CATTGAAAGGGAAAGAGATAT	0.423000													5	16					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74365888	74365888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74365888C>T	ENST00000226355.3	+	12	1683	c.1590C>T	c.(1588-1590)acC>acT	p.T530T		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	530	Albumin 3.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ATTTATTTACCTTTCACGCAG	0.393000													7	60					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69335027	69335027	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:69335027C>T	ENST00000260364.5	+	11	1776	c.1475C>T	c.(1474-1476)tCc>tTc	p.S492F	NOX5_ENST00000455873.3_Missense_Mutation_p.S475F|RP11-809H16.4_ENST00000559495.1_RNA|NOX5_ENST00000448182.3_Missense_Mutation_p.S464F|NOX5_ENST00000530406.2_Missense_Mutation_p.S482F|NOX5_ENST00000388866.3_Missense_Mutation_p.S510F			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	510	C-terminal catalytic region.|FAD-binding FR-type.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CACATTCGGTCCCAAGGCCAG	0.557000													13	73					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45297465	45297465	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45297465C>T	ENST00000270279.3	+	9	1352	c.1289C>T	c.(1288-1290)cCc>cTc	p.P430L	CBLC_ENST00000341505.4_Missense_Mutation_p.P384L	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	430					cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				CCCCAGGTGCCCCTTTCGGCT	0.612000			M		AML								40	204					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62398280	62398280	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62398280G>A	ENST00000346178.4	-	12	1260	c.1245C>T	c.(1243-1245)tcC>tcT	p.S415S	GANAB_ENST00000356638.3_Silent_p.S393S|GANAB_ENST00000540933.1_Silent_p.S296S|GANAB_ENST00000534779.1_Silent_p.S301S	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	393					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GGTAGCCGAGGGAGAAGAGTG	0.582000													7	22					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229917	21229917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21229917G>A	ENST00000233242.1	-	26	9950	c.9823C>T	c.(9823-9825)Cca>Tca	p.P3275S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3275					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACTGCTTTTGGGAACACATAG	0.478000													16	49					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168819864	168819864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168819864C>T	ENST00000464456.1	-	9	3364	c.2164G>A	c.(2164-2166)Gag>Aag	p.E722K	MECOM_ENST00000433243.2_Missense_Mutation_p.E732K|MECOM_ENST00000460814.1_Missense_Mutation_p.E722K|MECOM_ENST00000392736.3_Missense_Mutation_p.E731K|MECOM_ENST00000472280.1_Missense_Mutation_p.E732K|MECOM_ENST00000264674.3_Missense_Mutation_p.E796K|MECOM_ENST00000468789.1_Missense_Mutation_p.E731K|MECOM_ENST00000494292.1_Missense_Mutation_p.E910K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GTATAGCGCTCCTTTCCCTTC	0.483000													13	43					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25701888	25701888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:25701888C>T	ENST00000349320.3	-	10	1445	c.1057G>A	c.(1057-1059)Gaa>Aaa	p.E353K	RHCE_ENST00000413854.1_Intron|RHCE_ENST00000425135.1_Missense_Mutation_p.G278E|RHCE_ENST00000243186.6_Intron|RHCE_ENST00000340849.4_Intron|RHCE_ENST00000349438.4_Missense_Mutation_p.G324E|RHCE_ENST00000294413.7_Missense_Mutation_p.E369K|RHCE_ENST00000346452.4_Missense_Mutation_p.E218K|RHCE_ENST00000455194.1_Missense_Mutation_p.E264K|RHCE_ENST00000374352.2_Missense_Mutation_p.E353K			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	369						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		AAGCTGAGTTCCCCAATGCTG	0.547000													45	172					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79314691	79314691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79314691G>A	ENST00000305089.3	-	2	128	c.48C>T	c.(46-48)ttC>ttT	p.F16F		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	16					cell proliferation	extracellular region	sugar binding	p.F16L(2)		central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						TCAGAGACAGGAACATCAGGG	0.473000													16	33					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164507064	164507064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164507064C>T	ENST00000503008.1	-	6	1236	c.260G>A	c.(259-261)gGg>gAg	p.G87E	MARCH1_ENST00000514618.1_Missense_Mutation_p.G343E|MARCH1_ENST00000274056.7_Missense_Mutation_p.G87E|MARCH1_ENST00000339875.5_Missense_Mutation_p.G70E	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	87					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CTCTTCATCCCCTTCGCAGTG	0.522000													12	35					0	0	1	0	0
TM4SF20	79853	broad.mit.edu	37	2	228235632	228235632	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228235632C>T	ENST00000304568.3	-	2	285	c.249_splice	c.e2+1	p.G83_splice		NM_024795.3	NP_079071.2	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	83						integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(2)	10		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		CATACTTACTCCAGTTCTGTT	0.448000													151	369					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9034648	9034648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9034648C>T	ENST00000383836.3	-	20	2927	c.2500G>A	c.(2500-2502)Gac>Aac	p.D834N	SRGAP3_ENST00000360413.3_Missense_Mutation_p.D810N	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	834					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GACTGGAGGTCGTTTTTGGAA	0.582000			T	RAF1	pilocytic astrocytoma								20	64					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52569430	52569430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52569430G>A	ENST00000389534.4	-	7	2164	c.1705C>T	c.(1705-1707)Ctc>Ttc	p.L569F	ZNF841_ENST00000594295.1_Missense_Mutation_p.L569F|ZNF841_ENST00000359973.2_Intron|ZNF841_ENST00000426391.2_Missense_Mutation_p.L453F|ZNF432_ENST00000598446.1_Intron	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						TTACAATGGAGAGGTTTCTCT	0.403000													19	68					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71130426	71130426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:71130426C>T	ENST00000333538.5	+	7	1745	c.1111C>T	c.(1111-1113)Ctt>Ttt	p.L371F	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	371	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CATGGAGGTCCTTCCTTGCTC	0.522000													38	123					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75991451	75991451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75991451C>T	ENST00000274364.6	+	32	4463	c.4166C>T	c.(4165-4167)tCc>tTc	p.S1389F	IQGAP2_ENST00000396234.3_Missense_Mutation_p.S885F|IQGAP2_ENST00000502745.1_Missense_Mutation_p.S885F|CTD-2384B11.2_ENST00000507514.1_RNA|IQGAP2_ENST00000379730.3_Missense_Mutation_p.S891F	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1389					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CACGTGTCATCCGAAAATAAA	0.418000													32	71					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70934981	70934981	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70934981C>T	ENST00000393567.2	-	53	9124	c.8974G>A	c.(8974-8976)Gag>Aag	p.E2992K		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2992										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TACTCAGCCTCAGGGGGGATG	0.572000													23	197					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197066061	197066061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197066061G>A	ENST00000260983.2	-	29	4841	c.4659C>T	c.(4657-4659)tcC>tcT	p.S1553S	HECW2_ENST00000409111.1_Silent_p.S1197S	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	1553	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CATAAAGCATGGAAAAGGATG	0.453000													34	83					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34002668	34002668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34002668G>A	ENST00000373381.4	-	62	10009	c.9833C>T	c.(9832-9834)cCt>cTt	p.P3278L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3134						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGCACACCAGGGTCCGCACA	0.517000													29	52					0	0	1	0	0
CUL4A	8451	broad.mit.edu	37	13	113909298	113909298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113909298C>T	ENST00000451881.1	+	18	1839	c.1590C>T	c.(1588-1590)tcC>tcT	p.S530S	CUL4A_ENST00000375441.3_Silent_p.S530S|CUL4A_ENST00000375440.4_Silent_p.S630S|CUL4A_ENST00000326335.4_Silent_p.S530S	NM_001278513.1|NM_003589.2	NP_001265442.1|NP_003580.1	Q13619	CUL4A_HUMAN	cullin 4A	630					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|skin(1)	17	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			CGCTGCAGTCCCTGGCCTGTG	0.458000													13	34					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248570362	248570362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248570362G>A	ENST00000366474.1	+	1	1067	c.1067G>A	c.(1066-1068)gGg>gAg	p.G356E		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	356					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGGCCTTGGGGAGGTTCAAG	0.522000													40	134					0	0	1	0	0
SLC17A9	63910	broad.mit.edu	37	20	61596512	61596512	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61596512C>T	ENST00000370349.3	+	10	1125	c.921C>T	c.(919-921)ctC>ctT	p.L307L	SLC17A9_ENST00000370351.4_Silent_p.L313L|SLC17A9_ENST00000488738.1_3'UTR			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	313					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						TGCGGAAGCTCATGCAGGTAG	0.577000													21	42					0	0	1	0	0
SIX3	6496	broad.mit.edu	37	2	45170038	45170038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:45170038G>A	ENST00000260653.3	+	1	1137	c.795G>A	c.(793-795)gcG>gcA	p.A265A		NM_005413.3	NP_005404.1	O95343	SIX3_HUMAN	SIX homeobox 3	265	Poly-Ala.				visual perception	nucleus				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|skin(1)	11		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GCGCCGCGGCGGCCAAGAACA	0.682000													12	16					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126208159	126208159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126208159C>T	ENST00000290868.2	-	17	1721	c.1668G>A	c.(1666-1668)agG>agA	p.R556R	UROC1_ENST00000383579.3_Silent_p.R616R	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	556					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		TGGAGGTCTCCCTAAAGGGGC	0.498000													37	141					0	0	1	0	0
SPINK7	84651	broad.mit.edu	37	5	147693683	147693683	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147693683G>A	ENST00000274565.4	+	3	169	c.108G>A	c.(106-108)aaG>aaA	p.K36K	SPINK7_ENST00000523535.1_Silent_p.K10K|SPINK7_ENST00000514394.1_3'UTR|RP11-373N22.3_ENST00000501695.3_RNA	NM_032566.2	NP_115955.1	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7 (putative)	36	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATTTACAAGAAGTATCCAG	0.473000													67	167					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97485093	97485093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:97485093C>T	ENST00000376705.2	+	2	1081	c.1057C>T	c.(1057-1059)Ctc>Ttc	p.L353F		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	353						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					CTTCTTTGGGCTCACTGAGTT	0.463000													31	79					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73678100	73678100	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73678100C>T	ENST00000264448.6	+	8	4554	c.4443C>T	c.(4441-4443)ccC>ccT	p.P1481P	ALMS1_ENST00000409009.1_Silent_p.P1439P|ALMS1_ENST00000377715.1_Silent_p.P1481P	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1481	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GAGAGAAGCCCATTGTTATCT	0.507000													65	131					0	0	1	0	0
FCGRT	2217	broad.mit.edu	37	19	50027802	50027802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50027802C>T	ENST00000221466.5	+	5	1126	c.640C>T	c.(640-642)Cct>Tct	p.P214S	FCGRT_ENST00000599988.1_Intron|FCGRT_ENST00000596975.1_Missense_Mutation_p.P122S|FCGRT_ENST00000594823.1_3'UTR|FCGRT_ENST00000426395.3_Missense_Mutation_p.P214S	NM_001136019.2	NP_001129491.1	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	214	Alpha-3.				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			endometrium(3)|kidney(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	9		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		ACCCAGCAGCCCTGGCTTTTC	0.667000													27	86					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066278	73066278	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73066278G>A	ENST00000429829.1	-	0	6310					NR_001564.2																						GATCCCAGACGATTATAATCA	0.488000													27	19					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203680140	203680140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203680140C>T	ENST00000357681.5	+	12	3058	c.1935C>T	c.(1933-1935)ttC>ttT	p.F645F	ATP2B4_ENST00000391954.2_Silent_p.F645F|ATP2B4_ENST00000367218.3_Silent_p.F645F|ATP2B4_ENST00000341360.2_Silent_p.F645F|ATP2B4_ENST00000367219.3_Silent_p.F633F	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	645					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding	p.F645fs*18(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ACCGGGACTTCGATGACACAG	0.532000													36	94					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	156956528	156956528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:156956528C>T	ENST00000348165.5	+	2	451	c.91C>T	c.(91-93)Cgt>Tgt	p.R31C	UBE3C_ENST00000389103.4_Intron	NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	31	Cis-determinant of acceptor ubiquitin- binding.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TCTTTTACATCGTACTCAGGA	0.328000													30	75					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325338	150325338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150325338G>A	ENST00000493969.1	-	3	301	c.124C>T	c.(124-126)Cgt>Tgt	p.R42C	GIMAP6_ENST00000328902.5_Silent_p.I116I	NM_001244071.1	NP_001231000.1	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	284							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGATAAGACGATGGCTTGGC	0.632000													23	76					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	170008397	170008397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:170008397G>A	ENST00000367765.1	-	4	1733	c.232C>T	c.(232-234)Cca>Tca	p.P78S	KIFAP3_ENST00000490550.1_5'UTR|KIFAP3_ENST00000367767.1_Missense_Mutation_p.P74S|KIFAP3_ENST00000361580.2_Missense_Mutation_p.P118S|KIFAP3_ENST00000538366.1_Missense_Mutation_p.P40S	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	118					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AAAGGAGGTGGATCTTTAGGC	0.313000													12	22					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46772028	46772028	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:46772028C>T	ENST00000394809.4	-	3	711	c.596G>A	c.(595-597)gGg>gAg	p.G199E	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	199				G -> R (in Ref. 1; CAC42766).	cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CTCCGCTGTCCCCTCCAGCAC	0.617000													3	9					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25479220	25479220	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25479220G>A	ENST00000453082.2	+	0	1761					NR_003343.1																						GAGCCTGGAGGAAGACTCGTG	0.577000													9	12					0	0	1	0	0
PROM1	8842	broad.mit.edu	37	4	15991445	15991445	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:15991445G>A	ENST00000505450.1	-	18	2571	c.1959C>T	c.(1957-1959)ccC>ccT	p.P653P	PROM1_ENST00000543373.1_Silent_p.P653P|PROM1_ENST00000539194.1_Silent_p.P662P|PROM1_ENST00000510224.1_Silent_p.P662P|PROM1_ENST00000540805.1_Silent_p.P662P|PROM1_ENST00000447510.2_Silent_p.P662P|PROM1_ENST00000508167.1_Silent_p.P653P	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	662					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						AATTTCCTGGGGGCTACAAAA	0.438000													3	7					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61262370	61262370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61262370C>T	ENST00000344731.5	+	7	825	c.723C>T	c.(721-723)gaC>gaT	p.D241D	SERPINB13_ENST00000269489.5_Intron	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	241					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						AAAACAACGACCTAAGCATGT	0.428000													41	108					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236902620	236902620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236902620C>T	ENST00000366578.4	+	10	1061	c.895C>T	c.(895-897)Cgc>Tgc	p.R299C	ACTN2_ENST00000542672.1_Missense_Mutation_p.R299C|ACTN2_ENST00000492634.1_3'UTR|ACTN2_ENST00000546208.1_Intron	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	299					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			ATGGATTCGTCGCACGATCCC	0.527000													50	145					0	0	1	0	0
CD27	939	broad.mit.edu	37	12	6554368	6554368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6554368G>A	ENST00000266557.3	+	1	336	c.107G>A	c.(106-108)gGa>gAa	p.G36E	CD27-AS1_ENST00000399492.2_RNA|CD27-AS1_ENST00000545339.1_RNA	NM_001242.4	NP_001233.1	P26842	CD27_HUMAN	CD27 molecule	36					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						TGGGCTCAGGGAAAGCTGTGC	0.602000													5	19					0	0	1	0	0
INS-IGF2	723961	broad.mit.edu	37	11	2170415	2170415	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2170415G>A	ENST00000397270.1	-	3	406	c.348C>T	c.(346-348)tcC>tcT	p.S116S	IGF2_ENST00000300632.5_5'UTR|INS-IGF2_ENST00000481781.1_5'UTR	NM_001042376.2	NP_001035835.1	Q1WM24	Q1WM24_HUMAN		116					glucose metabolic process	extracellular region	hormone activity			haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	5		all_epithelial(84;0.00018)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.0832)|Lung(200;0.156)		AGAGGACCGGGGAGTCACTGG	0.602000													45	94					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13534810	13534810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:13534810C>T	ENST00000341083.3	-	5	778	c.482G>A	c.(481-483)cGa>cAa	p.R161Q	BEND7_ENST00000396898.2_Missense_Mutation_p.R226Q|BEND7_ENST00000378605.3_Missense_Mutation_p.R174Q|BEND7_ENST00000396900.2_Missense_Mutation_p.R213Q	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	213							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						ATTTCTCTTTCGTGAGACAGC	0.433000													31	114					0	0	1	0	0
LTBP3	4054	broad.mit.edu	37	11	65319621	65319621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65319621G>A	ENST00000301873.5	-	8	1621	c.1353C>T	c.(1351-1353)ttC>ttT	p.F451F	LTBP3_ENST00000536982.1_Silent_p.F77F|LTBP3_ENST00000322147.4_Silent_p.F451F	NM_001130144.2	NP_001123616.1	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding protein 3	451	TB 2.					extracellular region	calcium ion binding|growth factor binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(3)	23						AGATCTCCTTGAACGCAGCTG	0.557000											OREG0021081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	94					0	0	1	0	0
DAO	1610	broad.mit.edu	37	12	109293228	109293228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109293228C>T	ENST00000228476.3	+	10	1093	c.889C>T	c.(889-891)Cgc>Tgc	p.R297C	DAO_ENST00000551281.1_Missense_Mutation_p.R231C	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	297					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						AGAACAGCTTCGCACTGGACC	0.498000													15	29					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621389	179621389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179621389G>A	ENST00000589042.1	-	46	11038	c.10814C>T	c.(10813-10815)tCa>tTa	p.S3605L	TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S3434L|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3291							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATTCATATGATGATCCTTG	0.418000													21	55					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26581740	26581740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26581740C>T	ENST00000252992.4	+	4	418	c.287C>T	c.(286-288)cCt>cTt	p.P96L	CEP85_ENST00000451429.2_Missense_Mutation_p.P45L	NM_022778.2	NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	96						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						CATGTGATGCCTTCTACTTTA	0.498000													124	282					0	0	1	0	0
TLX1NB	100038246	broad.mit.edu	37	10	102849587	102849587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102849587C>T	ENST00000445873.1	-	3	1352	c.76G>A	c.(76-78)Gag>Aag	p.E26K		NM_001085398.1	NP_001078867.1	P0CAT3	TLXNB_HUMAN	TLX1 neighbor	26																	CCCATGGCCTCTTGGGAAAGG	0.657000													3	15					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176853515	176853515	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176853515C>T	ENST00000367654.2	-	19	3223	c.3210G>A	c.(3208-3210)gaG>gaA	p.E1070E	ASTN1_ENST00000424564.2_Silent_p.E1062E|ASTN1_ENST00000367657.3_Silent_p.E1062E|ASTN1_ENST00000361833.2_Silent_p.E1062E			O14525	ASTN1_HUMAN	astrotactin 1	1070	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CAGTGACTTTCTCTTGACGGA	0.507000													30	75					0	0	1	0	0
MS4A14	84689	broad.mit.edu	37	11	60164109	60164109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60164109G>A	ENST00000300187.6	+	1	335	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K	MS4A14_ENST00000531787.1_Intron|MS4A14_ENST00000395005.2_Missense_Mutation_p.E20K|MS4A14_ENST00000395001.1_5'UTR|MS4A14_ENST00000531783.1_Missense_Mutation_p.E20K	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	20						integral to membrane	receptor activity	p.E20Q(1)		autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						AAAACCAAACGAAACTGTATT	0.458000													12	32					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12364652	12364652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12364652C>T	ENST00000358136.3	+	26	6436	c.6306C>T	c.(6304-6306)tcC>tcT	p.S2102S	VPS13D_ENST00000356315.4_Silent_p.S2102S	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2102					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GAACCCATTCCCAGGGGCAGT	0.567000													22	61					0	0	1	0	0
C1orf65	164127	broad.mit.edu	37	1	223567678	223567678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:223567678G>A	ENST00000366875.3	+	1	964	c.861G>A	c.(859-861)ctG>ctA	p.L287L		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	287										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		GGGAGGAGCTGAAGCGCTCGG	0.657000													3	9					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147236	26147236	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:26147236T>A	ENST00000331351.5	+	2	1430	c.1038T>A	c.(1036-1038)taT>taA	p.Y346*	HS3ST4_ENST00000475436.1_3'UTR	NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	346					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		GGCTCCAGTATTTCCCCCTCT	0.542000													61	128					0	0	1	0	0
ACADSB	36	broad.mit.edu	37	10	124793927	124793927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124793927C>T	ENST00000358776.4	+	2	112	c.98C>T	c.(97-99)tCa>tTa	p.S33L	ACADSB_ENST00000496730.2_3'UTR|ACADSB_ENST00000368869.4_5'UTR	NM_001609.3	NP_001600.1	P45954	ACDSB_HUMAN	acyl-CoA dehydrogenase, short/branched chain	33					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	CCTCATGTCTCAAAATCTTCC	0.363000													8	103					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18828563	18828563	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:18828563G>A	ENST00000396576.2	+	13	2229	c.1728G>A	c.(1726-1728)aaG>aaA	p.K576K	RP11-499P20.2_ENST00000425669.1_RNA|CACNB2_ENST00000377329.4_Silent_p.K577K|CACNB2_ENST00000377331.2_Silent_p.K579K|CACNB2_ENST00000377328.1_Silent_p.K381K|CACNB2_ENST00000324631.7_Silent_p.K631K|CACNB2_ENST00000352115.6_Silent_p.K607K|CACNB2_ENST00000377319.3_Silent_p.K538K|CACNB2_ENST00000377315.4_Silent_p.K583K|CACNB2_ENST00000282343.8_Silent_p.K603K	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	631					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATAAATCCAAGGATCGCTACT	0.537000													9	84					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103055700	103055700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103055700C>T	ENST00000375735.2	+	41	6697	c.6553C>T	c.(6553-6555)Cat>Tat	p.H2185Y	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.H2185Y	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2185					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTGCAGAGATCATGACGAATT	0.363000													23	67					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153864301	153864301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:153864301C>T	ENST00000511601.1	+	2	280	c.92C>T	c.(91-93)cCt>cTt	p.P31L	FHDC1_ENST00000260008.3_Missense_Mutation_p.P31L			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	31					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					CAGAcacctcctccagcacct	0.517000													15	62					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29527590	29527590	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:29527590C>T	ENST00000358273.4	+	9	1422	c.1039C>T	c.(1039-1041)Cag>Tag	p.Q347*	NF1_ENST00000431387.4_Nonsense_Mutation_p.Q347*|NF1_ENST00000356175.3_Nonsense_Mutation_p.Q347*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	347					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CCTACTTGTTCAGTCCATGGT	0.348000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			42	62					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246829020	246829020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:246829020C>T	ENST00000366513.4	+	11	2260	c.1991C>T	c.(1990-1992)tCc>tTc	p.S664F		NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	664					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						GGAGGTGGCTCCTGTATTTTG	0.428000													28	64					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38139114	38139114	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38139114G>A	ENST00000308059.6	+	17	2572	c.2551G>A	c.(2551-2553)Gag>Aag	p.E851K	DLEC1_ENST00000346219.3_Missense_Mutation_p.E851K|DLEC1_ENST00000452631.2_Missense_Mutation_p.E851K			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	851					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GTTACACATTGAGGCTGTCTT	0.602000													23	31					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21370127	21370127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21370127C>T	ENST00000256958.2	+	12	1668	c.1572C>T	c.(1570-1572)tgC>tgT	p.C524C		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	524					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TGGGTGAATGCCCAAGAGATG	0.383000													24	53					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160721269	160721269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:160721269C>T	ENST00000274547.2	-	11	1575	c.1358G>A	c.(1357-1359)cGa>cAa	p.R453Q	GABRB2_ENST00000517547.1_Missense_Mutation_p.R255Q|GABRB2_ENST00000520240.1_Missense_Mutation_p.R415Q|GABRB2_ENST00000517901.1_Missense_Mutation_p.R352Q|GABRB2_ENST00000353437.6_Missense_Mutation_p.R415Q|GABRB2_ENST00000393959.1_Missense_Mutation_p.R453Q	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	453					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAGAGCATTTCGGCCAAAACT	0.532000													29	61					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28805325	28805325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:28805325G>A	ENST00000422425.2	+	24	1697	c.1653G>A	c.(1651-1653)agG>agA	p.R551R	PLB1_ENST00000327757.5_Silent_p.R562R|PLB1_ENST00000329020.6_Silent_p.R250R	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	562	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TCAACCTGAGGGAGCTGTACC	0.517000													5	12					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182026425	182026425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:182026425C>T	ENST00000339948.3	-	2	928	c.721G>A	c.(721-723)Gag>Aag	p.E241K		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						TCTCCGCCCTCGCGCCGGCCC	0.731000													4	11					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111542474	111542474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111542474G>A	ENST00000354925.2	-	6	1941	c.236C>T	c.(235-237)cCg>cTg	p.P79L	PITX2_ENST00000394595.3_Intron|PITX2_ENST00000306732.3_Missense_Mutation_p.P86L|PITX2_ENST00000394598.2_Missense_Mutation_p.P79L|PITX2_ENST00000557119.2_Missense_Mutation_p.P86L|PITX2_ENST00000355080.5_Missense_Mutation_p.P33L	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	79					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CTTCTTAGACGGGTCCTCGGC	0.577000													7	109					0	0	1	0	0
ACOT7	11332	broad.mit.edu	37	1	6445578	6445578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6445578G>A	ENST00000377855.2	-	1	295	c.149C>T	c.(148-150)cCc>cTc	p.P50L	ACOT7_ENST00000361521.4_Intron|ACOT7_ENST00000545482.1_Intron	NM_181864.2	NP_863654.1	O00154	BACH_HUMAN	acyl-CoA thioesterase 7	50						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity			kidney(1)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	16	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		GGCTCCACAGGGTGGGAGATC	0.652000													47	156					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47607787	47607787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47607787C>T	ENST00000371891.3	+	4	421	c.390C>T	c.(388-390)ggC>ggT	p.G130G	CYP4A22_ENST00000485117.1_3'UTR|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000371890.3_Silent_p.G130G|CYP4A22_ENST00000294337.3_Silent_p.G130G	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	130			G -> S (in allele CYP4A22*4, allele CYP4A22*10, allele CYP4A22*12, allele CYP4A22*13, allele CYP4A22*14 and allele CYP4A22*15; dbSNP:rs2056900).			endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TAGGGTACGGCTTGCTCCTGT	0.537000													30	40					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97852271	97852271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97852271C>T	ENST00000354565.2	+	1	730	c.730C>T	c.(730-732)Cat>Tat	p.H244Y	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						CTGTGGAGCCCATCTCTTCTC	0.408000													50	127					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46945084	46945084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46945084G>A	ENST00000313049.5	+	14	1923	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	PTH1R_ENST00000418619.1_Missense_Mutation_p.E574K|PTH1R_ENST00000430002.2_Missense_Mutation_p.E574K|PTH1R_ENST00000449590.1_Missense_Mutation_p.E574K			Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	574						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						CCTGGACGAGGAGGCCTCTGG	0.652000													57	120					0	0	1	0	0
PELP1	27043	broad.mit.edu	37	17	4577868	4577868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4577868G>A	ENST00000301396.4	-	13	2176	c.1951C>T	c.(1951-1953)Ccg>Tcg	p.P651S	PELP1_ENST00000269230.7_Missense_Mutation_p.P505S|PELP1_ENST00000572293.1_Missense_Mutation_p.P557S|PELP1_ENST00000574876.1_Missense_Mutation_p.P507S|PELP1_ENST00000436683.2_Missense_Mutation_p.P360S			Q8IZL8	PELP1_HUMAN	proline, glutamate and leucine rich protein 1	507	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						TGGCTTGGCGGGGCCATAGCT	0.642000													7	26					0	0	1	0	0
C1QC	714	broad.mit.edu	37	1	22974025	22974025	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22974025C>T	ENST00000374639.3	+	3	605	c.487C>T	c.(487-489)Ccc>Tcc	p.P163S	C1QC_ENST00000374640.4_Missense_Mutation_p.P163S|C1QC_ENST00000374637.1_Missense_Mutation_p.P163S	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	163	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTGCAAAGTCCCCGGCCTCTA	0.592000													14	46					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42807045	42807045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:42807045G>A	ENST00000514985.1	-	3	625	c.369C>T	c.(367-369)gtC>gtT	p.V123V	CTD-2325A15.5_ENST00000606056.1_RNA|SEPP1_ENST00000509276.1_Intron|SEPP1_ENST00000506577.1_Silent_p.V123V|SEPP1_ENST00000511224.1_Silent_p.V123V|SEPP1_ENST00000507920.1_Intron	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1	123					response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						AAAGAGTCCAGACATCTGTTT	0.323000													21	54					0	0	1	0	0
CC2D2B	387707	broad.mit.edu	37	10	97779519	97779519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97779519G>A	ENST00000344386.3	+	8	882	c.718G>A	c.(718-720)Gaa>Aaa	p.E240K	CC2D2B_ENST00000410012.2_Missense_Mutation_p.E240K|ENTPD1-AS1_ENST00000416301.1_RNA|RP11-690P14.4_ENST00000475252.2_Intron|ENTPD1-AS1_ENST00000458228.1_RNA|ENTPD1-AS1_ENST00000452728.1_RNA|ENTPD1-AS1_ENST00000454638.1_RNA|CC2D2B_ENST00000371198.2_Intron|ENTPD1-AS1_ENST00000451364.1_RNA	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	240										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		CTATTCAAAGGAAAGTTTCTG	0.333000													62	165					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132736524	132736524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132736524C>T	ENST00000265342.7	-	4	564	c.315G>A	c.(313-315)ggG>ggA	p.G105G		NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	105	Kazal-like.					extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATAAAACCTCCCATCAGAGC	0.587000													10	72					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10713855	10713855	+	Silent	SNP	G	G	A	rs147506563		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10713855G>A	ENST00000377022.3	-	11	2576	c.2259C>T	c.(2257-2259)gcC>gcT	p.A753A	CASZ1_ENST00000344008.5_Silent_p.A753A|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	753					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGGCAGTGGCGGCAGCCAGGG	0.672000													9	62					0	0	1	0	0
SERPINF1	5176	broad.mit.edu	37	17	1674335	1674335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:1674335G>A	ENST00000254722.4	+	4	459	c.296G>A	c.(295-297)cGa>cAa	p.R99Q	SERPINF1_ENST00000571870.1_3'UTR	NM_002615.5	NP_002606.3	P36955	PEDF_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	99					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	16						GCGGAGCAGCGAACAGAATCC	0.542000													56	52					0	0	1	0	0
GALNT3	2591	broad.mit.edu	37	2	166611219	166611219	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166611219G>T	ENST00000392701.3	-	9	2319	c.1544C>A	c.(1543-1545)cCt>cAt	p.P515H	GALNT3_ENST00000409882.1_Missense_Mutation_p.P253H	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	515	Ricin B-type lectin.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						CAGACATAGAGGCTGACCAAC	0.313000													7	18					8.12818e-05	8.14103e-05	1	1	0
DGKA	1606	broad.mit.edu	37	12	56345462	56345462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56345462G>A	ENST00000331886.5	+	18	1936	c.1482G>A	c.(1480-1482)gtG>gtA	p.V494V	DGKA_ENST00000394147.1_Silent_p.V494V|DGKA_ENST00000551156.1_Silent_p.V494V|DGKA_ENST00000549079.2_3'UTR	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	494	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	TGAGTAAAGTGGTACATATGG	0.433000													11	112					0	0	1	0	0
HOXD10	3236	broad.mit.edu	37	2	176982108	176982108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:176982108C>T	ENST00000249501.4	+	1	802	c.547C>T	c.(547-549)Cgt>Tgt	p.R183C	HOXD10_ENST00000490088.2_Intron	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	183						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GCTCAACCCTCGTGGCGCGGC	0.582000													27	86					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45387220	45387220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45387220C>T	ENST00000389039.6	-	32	4694	c.4309G>A	c.(4309-4311)Gag>Aag	p.E1437K	DUOX2_ENST00000603300.1_Missense_Mutation_p.E1437K			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1437					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TCGTTCTCCTCCACCTCTTGG	0.567000													23	47					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71907125	71907125	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71907125G>A	ENST00000393679.1	+	5	1114	c.678G>A	c.(676-678)gcG>gcA	p.A226A	FOLR1_ENST00000312293.4_Silent_p.A226A|FOLR1_ENST00000393681.2_Silent_p.A226A|FOLR1_ENST00000393676.3_Silent_p.A226A|RP11-807H22.7_ENST00000378140.3_RNA			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	226					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						AGGAGGTGGCGAGGTTCTATG	0.627000													26	52					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121613	50121613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50121613C>T	ENST00000374160.3	-	1	664	c.588G>A	c.(586-588)gaG>gaA	p.E196E	RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Silent_p.E196E|WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	196						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CATACAAGTTCTCCAGCCTCC	0.493000													35	83					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51215210	51215210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51215210G>A	ENST00000293441.1	-	6	972	c.954C>T	c.(952-954)atC>atT	p.I318I	SHANK1_ENST00000359082.3_Silent_p.I318I|SHANK1_ENST00000391814.1_Silent_p.I318I	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	318					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCACCTGGTGGATTTCCTGCC	0.642000													34	103					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69434189	69434189	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69434189C>T	ENST00000317746.2	-	1	56	c.14G>A	c.(13-15)tGg>tAg	p.W5*		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	5					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						GACTGACATCCATTTCAGAGA	0.408000													86	329					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86355248	86355248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86355248C>T	ENST00000370571.2	-	32	3337	c.2971G>A	c.(2971-2973)Gag>Aag	p.E991K	COL24A1_ENST00000436319.1_Missense_Mutation_p.E991K	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	991	Collagen-like 8.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTTACTGGCTCTCCTGGAAGT	0.378000													33	75					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140174612	140174612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140174612C>T	ENST00000526136.1	+	1	63	c.63C>T	c.(61-63)ctC>ctT	p.L21L	PCDHA2_ENST00000378132.1_Silent_p.L21L|PCDHA2_ENST00000520672.2_Silent_p.L21L|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGCTCCTCGCAGCCTGGG	0.622000													28	74					0	0	1	0	0
EFCAB4A	283229	broad.mit.edu	37	11	828658	828658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:828658G>A	ENST00000450448.1	+	2	556	c.51G>A	c.(49-51)ggG>ggA	p.G17G	EFCAB4A_ENST00000528542.2_Silent_p.G17G|EFCAB4A_ENST00000525077.1_Silent_p.G17G|AP006621.8_ENST00000532946.1_RNA	NM_173584.3	NP_775855.3	Q8N4Y2	EFC4A_HUMAN	EF-hand calcium binding domain 4A	17					store-operated calcium entry		calcium ion binding			endometrium(1)|large_intestine(1)|lung(1)	3		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGGAGGAGGGGGAACTCGAGG	0.642000													16	54					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110670406	110670406	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110670406G>A	ENST00000394634.2	-	10	1323	c.1116C>T	c.(1114-1116)ggC>ggT	p.G372G	CFI_ENST00000512148.1_Silent_p.G365G|CFI_ENST00000394635.3_Silent_p.G380G	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	372	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		GAATCCAACAGCCACCAATAT	0.438000													104	264					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223154	44223154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44223154C>T	ENST00000244314.5	+	2	643	c.444C>T	c.(442-444)gtC>gtT	p.V148V		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	148						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				GCGGGGCCGTCGAGACCCGCC	0.662000													4	17					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54844923	54844923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54844923G>A	ENST00000291759.4	-	8	1476	c.1420C>T	c.(1420-1422)Ccc>Tcc	p.P474S	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	474						integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CACCTTGGGGGGCTTCTCTGG	0.547000													18	71					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88027630	88027630	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88027630T>C	ENST00000227266.5	-	7	1050	c.936A>G	c.(934-936)caA>caG	p.Q312Q		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	312			Q -> R (in PLS).		immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCCCAAAATCTTGGGCGTACT	0.458000													22	60					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233134126	233134126	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233134126C>A	ENST00000258229.8	-	32	5896	c.5662G>T	c.(5662-5664)Gga>Tga	p.G1888*	PCNXL2_ENST00000344698.2_Nonsense_Mutation_p.G540*	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1888						integral to membrane		p.G1888R(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GCCCCTCCTCCGTCCACGTCT	0.617000													8	47					7.48243e-07	7.50121e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179474571	179474571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179474571C>T	ENST00000589042.1	-	272	51803	c.51579G>A	c.(51577-51579)agG>agA	p.R17193R	TTN_ENST00000342992.6_Silent_p.R14625R|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Silent_p.R8128R|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.R8320R|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Silent_p.R8253R|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.R15552R|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15552	Fibronectin type-III 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCTTCCACCTTTCTTCAC	0.468000													157	416					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897633	175897633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175897633G>A	ENST00000359240.3	+	5	1627	c.957G>A	c.(955-957)atG>atA	p.M319I	ADAM29_ENST00000404450.4_Missense_Mutation_p.M319I|ADAM29_ENST00000445694.1_Missense_Mutation_p.M319I|ADAM29_ENST00000514159.1_Missense_Mutation_p.M319I	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	319	Peptidase M12B.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTACTTTCATGAACAAAACTT	0.403000													67	178					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23396742	23396742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23396742G>A	ENST00000324366.8	-	4	666	c.443C>T	c.(442-444)tCt>tTt	p.S148F	PRMT5_ENST00000538452.1_Missense_Mutation_p.S42F|PRMT5_ENST00000397440.4_Intron|PRMT5_ENST00000216350.8_Missense_Mutation_p.S87F|PRMT5_ENST00000397441.2_Missense_Mutation_p.S131F|PRMT5_ENST00000553641.1_5'UTR|PRMT5_ENST00000553897.1_Missense_Mutation_p.S104F	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	148					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TACCATGGAAGAGTGATGGCC	0.488000													23	55					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125621339	125621339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125621339C>T	ENST00000316519.6	+	17	2016	c.1810C>T	c.(1810-1812)Cgt>Tgt	p.R604C	AACS_ENST00000545511.1_Intron|AACS_ENST00000316543.10_Missense_Mutation_p.R202C|AACS_ENST00000261686.6_Intron|AACS_ENST00000543665.1_Intron	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	604					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		TAAGAGGATCCGTGACGCCAT	0.607000													16	72					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140732107	140732107	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140732107G>A	ENST00000523390.1	+	1	2280	c.2280G>A	c.(2278-2280)gaG>gaA	p.E760E	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAGACAGAGTTTAATTCTC	0.488000													11	54					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455121	84455121	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:84455121G>A	ENST00000377084.2	-	1	1407	c.522C>T	c.(520-522)ttC>ttT	p.F174F		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	174						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCACATACTGGAACACGTTGG	0.527000													25	79					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380453	56380453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56380453G>A	ENST00000526538.1	-	1	525	c.526C>T	c.(526-528)Cat>Tat	p.H176Y		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						CAGTAGAAATGATTGATTTCA	0.453000													13	50					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47944643	47944643	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47944643A>T	ENST00000236877.6	-	5	2213	c.1818T>A	c.(1816-1818)aaT>aaA	p.N606K	SLC8A2_ENST00000542837.1_Missense_Mutation_p.N362K|SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000539381.1_Missense_Mutation_p.N69K	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	606	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CAATGAAGAAATTATCCTTTT	0.542000													23	44					0	0	1	0	0
FASLG	356	broad.mit.edu	37	1	172634851	172634851	+	Missense_Mutation	SNP	C	C	T	rs80358236		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:172634851C>T	ENST00000367721.2	+	4	725	c.541C>T	c.(541-543)Ctt>Ttt	p.L181F	FASLG_ENST00000340030.3_3'UTR	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	181					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						GAAGGGTGGCCTTGTGATCAA	0.458000													14	95					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122437790	122437790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122437790C>T	ENST00000474629.2	+	14	5058	c.4792C>T	c.(4792-4794)Ctc>Ttc	p.L1598F	PARP14_ENST00000475640.1_3'UTR	NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1598	WWE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		TGTTCAGCGCCTCACGAAATC	0.388000													5	24					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103898452	103898452	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103898452C>T	ENST00000278070.2	+	3	458	c.419C>T	c.(418-420)tCt>tTt	p.S140F	PPRC1_ENST00000413464.2_Missense_Mutation_p.S140F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AATGCAGATTCTGAGAACCTT	0.532000													25	54					0	0	1	0	0
FANK1	92565	broad.mit.edu	37	10	127668815	127668815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:127668815G>A	ENST00000368695.1	+	2	203	c.81G>A	c.(79-81)aaG>aaA	p.K27K	FANK1_ENST00000368693.1_Silent_p.K33K|FANK1_ENST00000449042.2_Silent_p.K27K|FANK1_ENST00000368689.1_Silent_p.K27K	NM_145235.3	NP_660278.3	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains 1	33	Fibronectin type-III.					cytoplasm|nucleus				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(10)|ovary(1)|urinary_tract(1)	21		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				ATCTGGAAAAGAAAGCCAAAC	0.438000													32	44					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65239996	65239996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65239996G>A	ENST00000389722.3	-	24	5173	c.5120C>T	c.(5119-5121)tCa>tTa	p.S1707L	SPTB_ENST00000389720.3_Missense_Mutation_p.S1707L|SPTB_ENST00000389721.5_Missense_Mutation_p.S1707L|SPTB_ENST00000556626.1_Missense_Mutation_p.S1707L|SPTB_ENST00000542895.1_Missense_Mutation_p.S1707L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1707					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTCCTTTTCTGAAATCCACTG	0.547000													24	62					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106207896	106207896	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106207896C>T	ENST00000390548.2	-	0	906																											AAGACGTTCCCCTGCTGCCAC	0.597000													36	118					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111540184	111540184	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:111540184C>T	ENST00000261486.5	-	15	1540	c.1262_splice	c.e15-1	p.G422_splice	CTC-459M5.2_ENST00000506875.1_RNA|EPB41L4A_ENST00000507810.1_5'UTR|CTC-459M5.2_ENST00000505825.1_RNA	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	422						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TTGTAGAGTCCACTGGAGAGA	0.507000													35	72					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849514	73849514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73849514G>A	ENST00000523207.1	+	3	2512	c.1924G>A	c.(1924-1926)Gag>Aag	p.E642K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	642					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AGGGACAGAAGAGCACCAAAG	0.592000													37	101					0	0	1	0	0
SOX13	9580	broad.mit.edu	37	1	204086786	204086786	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204086786C>T	ENST00000367204.1	+	7	835	c.726C>T	c.(724-726)acC>acT	p.T242T	SOX13_ENST00000367203.4_3'UTR	NM_005686.2	NP_005677.2	Q9UN79	SOX13_HUMAN	SRY (sex determining region Y)-box 13	242	Pro-rich.				anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	13	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			TGCCTGTCACCCCTGACTCCC	0.587000													10	20					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21402245	21402245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21402245G>A	ENST00000313654.9	+	20	2575	c.2334G>A	c.(2332-2334)ggG>ggA	p.G778G	LAMA3_ENST00000399516.3_Silent_p.G778G	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	778					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAATGTAGGGAAGTCAAGTG	0.383000													32	74					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171168627	171168627	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171168627G>A	ENST00000441535.1	+	5	744	c.627_splice	c.e5+1	p.Q209_splice	FMO2_ENST00000209929.7_Splice_Site_p.Q209_splice|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000529935.1_Intron|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445290.1_RNA|RP1-127D3.4_ENST00000422841.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	209					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGCTGCTCAGGTGTGATGCT	0.498000													16	97					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60887760	60887760	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60887760T>C	ENST00000252999.3	-	67	9221	c.9155A>G	c.(9154-9156)gAg>gGg	p.E3052G		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	3052	Laminin G-like 2.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATTGTCCTGCTCCACGCTGTA	0.687000													3	12					0	0	1	0	0
AADACL2	344752	broad.mit.edu	37	3	151451837	151451837	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151451837C>T	ENST00000356517.3	+	1	123	c.14C>T	c.(13-15)gCt>gTt	p.A5V		NM_207365.3	NP_997248.2	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2	5						extracellular region|integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(13)|skin(2)	24			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GGGCTAAAAGCTCTCTGTTTG	0.388000													11	18					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67430797	67430797	+	Silent	SNP	G	G	A	rs111978289		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67430797G>A	ENST00000349015.3	-	10	1485	c.1047C>T	c.(1045-1047)ctC>ctT	p.L349L	ALDH3B2_ENST00000530069.1_Silent_p.L349L	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	349					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	CGGAGGGGGCGAGCAGGCAGG	0.617000													13	42					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142037485	142037485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142037485G>A	ENST00000264951.4	-	39	4684	c.4567C>T	c.(4567-4569)Cct>Tct	p.P1523S	XRN1_ENST00000392981.2_Missense_Mutation_p.P1524S	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1523					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						ACAGCTGAAGGATAATTTGCA	0.368000													5	11					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25490468	25490468	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25490468C>T	ENST00000453082.2	+	0	2619					NR_003343.1																						TGTATTGGGCCCCCACAGGCC	0.617000													6	23					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033554	95033554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95033554G>A	ENST00000557004.1	+	3	1318	c.897G>A	c.(895-897)atG>atA	p.M299I	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000298841.5_Missense_Mutation_p.M299I|SERPINA4_ENST00000555095.1_Missense_Mutation_p.M299I			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	299					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		AGATGCTAATGAGGTGGAACA	0.438000													18	53					0	0	1	0	0
GADL1	339896	broad.mit.edu	37	3	30885930	30885930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:30885930G>A	ENST00000454381.3	-	7	726	c.680C>T	c.(679-681)tCt>tTt	p.S227F	GADL1_ENST00000282538.5_Missense_Mutation_p.S227F			Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	227					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding			breast(2)|endometrium(3)|kidney(2)|lung(17)|upper_aerodigestive_tract(1)	25					Pyridoxal Phosphate(DB00114)	CCCAAGAAAAGAGGCTGCCTT	0.433000													52	152					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91389464	91389464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:91389464G>A	ENST00000509176.1	+	5	1971	c.1683G>A	c.(1681-1683)atG>atA	p.M561I	CCSER1_ENST00000432775.2_Missense_Mutation_p.M561I|CCSER1_ENST00000333691.8_Missense_Mutation_p.M561I	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		TGATAGAAATGAAGAAAAGAG	0.383000													12	33					0	0	1	0	0
RBM39	9584	broad.mit.edu	37	20	34312576	34312576	+	Silent	SNP	G	G	A	rs151187023		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34312576G>A	ENST00000361162.6	-	8	987	c.603C>T	c.(601-603)ttC>ttT	p.F201F	RBM39_ENST00000407261.4_Silent_p.F44F|RBM39_ENST00000253363.6_Silent_p.F201F|RBM39_ENST00000528062.3_Silent_p.F179F	NM_004902.3|NM_184234.2	NP_004893.1|NP_909122.1	Q14498	RBM39_HUMAN	RNA binding motif protein 39	201	RRM 1.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TAACATCGACGAACTCCACAT	0.413000													42	83					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39068745	39068745	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39068745C>T	ENST00000379907.4	+	12	1262	c.1135C>T	c.(1135-1137)Ctt>Ttt	p.L379F	ADAM32_ENST00000437682.2_Intron|ADAM32_ENST00000519315.1_Intron	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	379	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGTCAAATGTCTTCAGAATAA	0.393000													11	15					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57256424	57256424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57256424G>A	ENST00000278426.3	-	13	1729	c.1374C>T	c.(1372-1374)ttC>ttT	p.F458F	SLC43A1_ENST00000528450.1_Silent_p.F458F	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	458					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						CTGAGTGGAAGAAACCTCGAA	0.512000													13	65					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836687	142836687	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142836687C>T	ENST00000291009.3	+	4	433	c.393C>T	c.(391-393)ccC>ccT	p.P131P		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	131						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		CTGTAATCCCCATCAAAAACA	0.438000													66	187					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228474494	228474494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228474494C>T	ENST00000570156.2	+	40	10659	c.10585C>T	c.(10585-10587)Cgg>Tgg	p.R3529W	OBSCN_ENST00000366707.4_Missense_Mutation_p.R219W|OBSCN_ENST00000422127.1_Missense_Mutation_p.R3100W|OBSCN_ENST00000359599.6_Missense_Mutation_p.R1947W|OBSCN_ENST00000284548.11_Missense_Mutation_p.R3100W|OBSCN_ENST00000366709.4_Missense_Mutation_p.R219W	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2562	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CGTCTTCTCCCGGGAGCTCAC	0.612000													20	42					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20329572	20329572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20329572C>T	ENST00000302555.5	-	7	1337	c.1188G>A	c.(1186-1188)agG>agA	p.R396R	GP2_ENST00000381360.5_Silent_p.R252R|GP2_ENST00000381362.4_Silent_p.R399R|GP2_ENST00000341642.5_Silent_p.R249R			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	399	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CATAGCAGTTCCTCAACACCA	0.483000													15	82					0	0	1	0	0
CIZ1	25792	broad.mit.edu	37	9	130952661	130952661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130952661G>A	ENST00000538431.1	-	3	480	c.233C>T	c.(232-234)tCc>tTc	p.S78F	CIZ1_ENST00000277465.4_Missense_Mutation_p.S78F|CIZ1_ENST00000325721.8_Missense_Mutation_p.S78F|CIZ1_ENST00000357558.5_Missense_Mutation_p.S78F|CIZ1_ENST00000372954.1_Missense_Mutation_p.S78F|CIZ1_ENST00000476727.2_Intron|CIZ1_ENST00000393608.1_Missense_Mutation_p.S78F|CIZ1_ENST00000372948.3_Missense_Mutation_p.S78F|CIZ1_ENST00000541172.1_Intron|CIZ1_ENST00000372938.5_Missense_Mutation_p.S78F	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	78						nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						GTTGAGGAGGGAGGCTGAGTT	0.577000													8	20					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73472451	73472451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73472451G>A	ENST00000224721.6	+	27	3270	c.3265G>A	c.(3265-3267)Ggc>Agc	p.G1089S	C10orf105_ENST00000441508.2_3'UTR|C10orf105_ENST00000398786.2_3'UTR	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1084	Cadherin 10.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCGACACACGGGCACAGCCAC	0.577000													7	25					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1515939	1515939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:1515939G>A	ENST00000389470.4	-	39	5915	c.5916C>T	c.(5914-5916)tgC>tgT	p.C1972C	INTS1_ENST00000404767.3_Silent_p.C1768C			Q8N201	INT1_HUMAN	integrator complex subunit 1	1768					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CCCCACAGCAGCAGCTGAGCA	0.687000													4	11					0	0	1	0	0
IGLV3-12	28802	broad.mit.edu	37	22	23114868	23114868	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23114868G>A	ENST00000390313.2	+	0	149																											AACAACATTGGAAGTAAAGCT	0.562000													9	41					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45410347	45410347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45410347C>T	ENST00000332700.6	-	4	913	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	248						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E248K(1)		endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GAAAGCACTTCCTTTTCTTTG	0.418000													54	124					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57261486	57261486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57261486G>A	ENST00000278426.3	-	8	1206	c.851C>T	c.(850-852)aCc>aTc	p.T284I	SLC43A1_ENST00000533515.1_5'UTR|SLC43A1_ENST00000528450.1_Missense_Mutation_p.T284I	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	284					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						GTTTTCTGAGGTGCCCCGAAC	0.577000											OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	34					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93029461	93029461	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:93029461C>T	ENST00000523629.1	-	3	673	c.219G>A	c.(217-219)ccG>ccA	p.P73P	RUNX1T1_ENST00000521553.1_Silent_p.P36P|RUNX1T1_ENST00000436581.2_Silent_p.P84P|RUNX1T1_ENST00000360348.2_Silent_p.P36P|RUNX1T1_ENST00000396218.1_Silent_p.P46P|RUNX1T1_ENST00000520724.1_Silent_p.P36P|RUNX1T1_ENST00000265814.3_Silent_p.P73P|RUNX1T1_ENST00000422361.2_Silent_p.P36P|RUNX1T1_ENST00000518844.1_Silent_p.P46P	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	73					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TACACGTTGTCGGTGTAAATG	0.388000													17	84					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784985	9784985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9784985C>T	ENST00000304374.2	+	1	1728	c.1332C>T	c.(1330-1332)tcC>tcT	p.S444S		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	444					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ATCAGACGTCCCCAGATGGTG	0.547000													30	54					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976513	38976513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38976513G>A	ENST00000355481.4	+	34	5349	c.5218G>A	c.(5218-5220)Gag>Aag	p.E1740K	RYR1_ENST00000360985.3_Missense_Mutation_p.E1740K|RYR1_ENST00000359596.3_Missense_Mutation_p.E1740K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1740	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCTCACGCCTGAGACCCGCGC	0.632000													28	93					0	0	1	0	0
NXPE1	120400	broad.mit.edu	37	11	114393141	114393141	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:114393141C>T	ENST00000536271.1	-	4	1584	c.341G>A	c.(340-342)tGg>tAg	p.W114*	NXPE1_ENST00000424269.1_Nonsense_Mutation_p.W398*|NXPE1_ENST00000251921.2_Nonsense_Mutation_p.W256*					neurexophilin and PC-esterase domain family, member 1																		ATGTTTTTTCCATTGAATCTG	0.373000													37	83					0	0	1	0	0
CLEC3B	7123	broad.mit.edu	37	3	45077054	45077054	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45077054C>T	ENST00000296130.4	+	3	427	c.247C>T	c.(247-249)Ctg>Ttg	p.L83L	CLEC3B_ENST00000428034.1_Silent_p.L41L|CLEC3B_ENST00000490386.1_3'UTR	NM_003278.2	NP_003269.2	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	83	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding			endometrium(1)|lung(3)	4				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAATGCTTTCTGGCCTTCAC	0.627000													25	36					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370539	35370539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35370539C>T	ENST00000373347.1	-	3	714	c.446G>A	c.(445-447)gGg>gAg	p.G149E	DLGAP3_ENST00000235180.4_Missense_Mutation_p.G149E			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	149					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				TGGCCCGGGCCCTGCCCCTGC	0.627000													12	25					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21896403	21896403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21896403G>A	ENST00000399982.2	-	3	1290	c.1226C>T	c.(1225-1227)tCc>tTc	p.S409F	CHD8_ENST00000557364.1_Missense_Mutation_p.S409F|CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Missense_Mutation_p.S130F	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	409	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GGCCCCTTGGGAAGAGCCAGC	0.473000													11	95					0	0	1	0	0
HMGCS1	3157	broad.mit.edu	37	5	43298724	43298724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:43298724G>A	ENST00000325110.6	-	3	550	c.344C>T	c.(343-345)tCt>tTt	p.S115F	HMGCS1_ENST00000433297.2_Missense_Mutation_p.S115F	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	115					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						TGTATTCCCAGACTCTTCAAA	0.438000													42	104					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47247088	47247088	+	Nonstop_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47247088T>C	ENST00000300404.2	+	11	1758	c.1699T>C	c.(1699-1701)Taa>Caa	p.*567Q	B4GALNT2_ENST00000504681.1_Nonstop_Mutation_p.*481Q|B4GALNT2_ENST00000393354.2_Nonstop_Mutation_p.*507Q	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	0					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			ATGTGCCGCATAAAGGTGTGA	0.502000													13	25					0	0	1	0	0
TNFSF8	944	broad.mit.edu	37	9	117666367	117666367	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117666367C>T	ENST00000223795.2	-	4	662	c.549G>A	c.(547-549)acG>acA	p.T183T	TNFSF8_ENST00000474301.1_Intron	NM_001244.3	NP_001235.1	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily, member 8	183					cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding	p.T183T(2)		endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(3)|urinary_tract(1)	12						ATACGTGTTTCGTTTGCATTC	0.418000													57	107					0	0	1	0	0
GZMK	3003	broad.mit.edu	37	5	54326282	54326282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54326282C>T	ENST00000231009.2	+	3	303	c.233C>T	c.(232-234)cCc>cTc	p.P78L	CTD-2313F11.1_ENST00000595218.1_RNA|CTD-2313F11.1_ENST00000596137.1_RNA	NM_002104.2	NP_002095.1	P49863	GRAK_HUMAN	granzyme K (granzyme 3; tryptase II)	78	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)	15		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GGCCAGTCTCCCACTGTGGTT	0.438000													36	110					0	0	1	0	0
S100P	6286	broad.mit.edu	37	4	6695749	6695749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6695749G>A	ENST00000296370.3	+	1	954	c.90G>A	c.(88-90)aaG>aaA	p.K30K	S100P_ENST00000513778.1_Intron	NM_005980.2	NP_005971.1	P25815	S100P_HUMAN	S100 calcium binding protein P	30	EF-hand 1.				endothelial cell migration	cytoplasm|nucleus	calcium ion binding|calcium-dependent protein binding|magnesium ion binding			prostate(1)	1		Myeloproliferative disorder(84;0.0255)		Colorectal(103;0.011)	Cromoglicate(DB01003)	CCCTGACCAAGGGGGAGCTCA	0.597000													20	40					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228479753	228479753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228479753G>A	ENST00000570156.2	+	44	11855	c.11781G>A	c.(11779-11781)caG>caA	p.Q3927Q	OBSCN_ENST00000366707.4_Silent_p.Q617Q|OBSCN_ENST00000422127.1_Silent_p.Q3498Q|OBSCN_ENST00000359599.6_Silent_p.Q2345Q|OBSCN_ENST00000284548.11_Silent_p.Q3498Q|OBSCN_ENST00000366709.4_Silent_p.Q617Q	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2965	Ig-like 40.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCTGAGGCAGGAGGGGACCA	0.627000													29	65					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22202047	22202047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:22202047G>A	ENST00000344041.6	-	13	1249	c.937C>T	c.(937-939)Cct>Tct	p.P313S	RAPGEF5_ENST00000401957.2_Missense_Mutation_p.P163S	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	163					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						TCATCTTCAGGTAACCAGTCT	0.348000													20	59					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68021426	68021426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68021426G>A	ENST00000412757.2	-	12	2109	c.1444C>T	c.(1444-1446)Ctt>Ttt	p.L482F	DPEP2_ENST00000393847.1_Missense_Mutation_p.L482F|DPEP2_ENST00000572888.1_Missense_Mutation_p.L482F			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	482					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		CACAGAATAAGGACTGGGAAG	0.542000													20	174					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325305	158325305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158325305C>T	ENST00000444681.2	+	2	567	c.274C>T	c.(274-276)Cct>Tct	p.P92S	CD1E_ENST00000368161.3_Missense_Mutation_p.P191S|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368167.3_Missense_Mutation_p.P191S|CD1E_ENST00000368163.3_Missense_Mutation_p.P191S|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368160.3_Missense_Mutation_p.P191S|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.P189S|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368165.3_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	191					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					TCACACCTGCCCTCGATTTCT	0.502000													4	45					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6897452	6897452	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6897452C>T	ENST00000312053.4	+	5	445	c.408C>T	c.(406-408)tgC>tgT	p.C136C	EMR1_ENST00000601198.1_3'UTR|EMR1_ENST00000450315.3_Silent_p.C136C|EMR1_ENST00000381404.4_Silent_p.C84C|EMR1_ENST00000250572.8_Silent_p.C136C|EMR1_ENST00000381407.5_Intron	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	136	EGF-like 3; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TCAATGAGTGCCTCACCAGCA	0.478000													25	46					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31743748	31743748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31743748G>A	ENST00000375686.3	-	3	743	c.506C>T	c.(505-507)gCc>gTc	p.A169V	VWA7_ENST00000375688.4_Missense_Mutation_p.A169V|VWA7_ENST00000447450.1_Missense_Mutation_p.A169V|VWA7_ENST00000467576.1_Intron	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	169						extracellular region											CACCTGCAGGGCATGAAGTGC	0.657000													75	145					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32526727	32526727	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32526727G>A	ENST00000286827.3	-	18	3480	c.3009C>T	c.(3007-3009)gcC>gcT	p.A1003A	TIAM1_ENST00000541036.1_Silent_p.A943A	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1003					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GGCAAAATGCGGCCACCTGTT	0.582000													27	69					0	0	1	0	0
EPHX4	253152	broad.mit.edu	37	1	92511195	92511195	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92511195C>T	ENST00000370383.4	+	4	680	c.582C>T	c.(580-582)ttC>ttT	p.F194F		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	194						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						TTATTAACTTCCCTCATCCAA	0.388000													35	99					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236755334	236755334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236755334G>A	ENST00000366582.3	-	11	1495	c.1381C>T	c.(1381-1383)Cat>Tat	p.H461Y	HEATR1_ENST00000366581.2_Missense_Mutation_p.H461Y	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	461					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACAAACTGATGGAAAAGCTCT	0.353000													27	104					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55220936	55220936	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55220936G>A	ENST00000413439.1	+	0	925																											TTTGATTGAGGAAGGAGAAAA	0.572000													7	21					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48335705	48335705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:48335705C>T	ENST00000428869.2	-	4	324	c.66G>A	c.(64-66)caG>caA	p.Q22Q	MRO_ENST00000398439.3_Silent_p.Q22Q|MRO_ENST00000587291.1_Intron|MRO_ENST00000431965.2_Intron|MRO_ENST00000436348.2_Intron|MRO_ENST00000256425.2_Silent_p.Q22Q|MRO_ENST00000588444.1_Silent_p.Q22Q			Q9BYG7	MSTRO_HUMAN	maestro	22						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		ATGTCCTTTTCTGCTTGGGCT	0.413000													33	77					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121356038	121356038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121356038C>T	ENST00000314583.3	-	7	611	c.520G>A	c.(520-522)Gga>Aga	p.G174R	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Intron	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	174					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		TAGTCATATCCCAGAGCTGCT	0.547000													7	121					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230224	56230224	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56230224G>A	ENST00000279791.1	-	1	653	c.654C>T	c.(652-654)ctC>ctT	p.L218L		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					CTACTACAATGAGAGTGTAGG	0.488000													6	24					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56823451	56823451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:56823451C>T	ENST00000257287.4	+	5	659	c.535C>T	c.(535-537)Ccc>Tcc	p.P179S	CEP135_ENST00000422247.2_Missense_Mutation_p.P179S	NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	179					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					ACCGGTTCCTCCCTCTGAAGT	0.408000													32	151					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231222521	231222521	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231222521C>T	ENST00000243810.6	+	3	109	c.107_splice	c.e3-1	p.L37_splice	SP140_ENST00000486687.2_Splice_Site_p.A760_splice|SP140L_ENST00000444636.1_Splice_Site_p.L37_splice|SP140L_ENST00000458341.1_5'UTR|SP140L_ENST00000415673.2_Splice_Site_p.L37_splice|SP140L_ENST00000396563.4_Splice_Site_p.L37_splice			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	37	HSR.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						TTTCCTTAGGCTGTTCACGGA	0.373000													53	182					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204490	9204490	+	Silent	SNP	G	G	A	rs139852545	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9204490G>A	ENST00000429566.3	+	1	636	c.570G>A	c.(568-570)acG>acA	p.T190T		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TTTCGTGCACGGACACCTCTG	0.562000													48	108					0	0	1	0	0
OR8B3	390271	broad.mit.edu	37	11	124267101	124267101	+	Silent	SNP	G	G	A	rs140121900	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124267101G>A	ENST00000354597.3	-	1	163	c.147C>T	c.(145-147)ttC>ttT	p.F49F		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AATTTAGACCGAAAAGAATGA	0.418000													69	92					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90504325	90504325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:90504325G>A	ENST00000369393.3	-	3	640	c.525C>T	c.(523-525)ctC>ctT	p.L175L	MDN1_ENST00000428876.1_Silent_p.L175L			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	175					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGCTTCTGAGGAGAGGGACAC	0.542000													17	41					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55142285	55142285	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55142285G>A	ENST00000370862.3	+	5	1206	c.870G>A	c.(868-870)gcG>gcA	p.A290A		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	290					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCGCTGTGGCGGCTGAAATAA	0.498000													16	51					0	0	1	0	0
ENTPD8	377841	broad.mit.edu	37	9	140331432	140331432	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140331432C>T	ENST00000371506.2	-	5	627	c.444G>A	c.(442-444)caG>caA	p.Q148Q	ENTPD8_ENST00000472938.1_Silent_p.Q148Q|ENTPD8_ENST00000344119.2_Silent_p.Q148Q	NM_001033113.1	NP_001028285.1	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	148						integral to membrane|plasma membrane	ATP binding			biliary_tract(1)|lung(4)|prostate(1)|skin(1)	7	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GGCCCAGGACCTGGGTGACTG	0.662000													12	71					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49067928	49067928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:49067928C>T	ENST00000376265.2	-	36	4208	c.4147G>A	c.(4147-4149)Gag>Aag	p.E1383K	CACNA1F_ENST00000323022.5_Missense_Mutation_p.E1372K|CACNA1F_ENST00000376251.1_Missense_Mutation_p.E1318K	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1383		Calcium ion selectivity and permeability (By similarity).			axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	TGCCATGCCTCACCAGTGGCA	0.547000													16	17					0	0	1	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98728846	98728846	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:98728846A>G	ENST00000288985.7	+	14	2288	c.1983A>G	c.(1981-1983)caA>caG	p.Q661Q	ERCC6L2_ENST00000466840.1_3'UTR|ERCC6L2_ENST00000437817.1_Silent_p.Q472Q	NM_001010895.2	NP_001010895.1	Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	661	Helicase C-terminal.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										TGTTTTAGCAACTTCACTGTG	0.393000													19	62					0	0	1	0	0
AGAP7	653268	broad.mit.edu	37	10	51465313	51465313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:51465313C>T	ENST00000374095.5	-	7	1268	c.1143G>A	c.(1141-1143)aaG>aaA	p.K381K		NM_001077685.1	NP_001071153.1	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	381	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	11						TGCTTTTCTTCTTTAGGTGTT	0.517000													30	111					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73821098	73821098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73821098G>A	ENST00000342056.2	+	7	1495	c.1097G>A	c.(1096-1098)aGa>aAa	p.R366K	KCNQ5_ENST00000414165.2_Missense_Mutation_p.R366K|KCNQ5_ENST00000403813.2_Missense_Mutation_p.R366K|KCNQ5_ENST00000402622.2_Missense_Mutation_p.R366K|KCNQ5_ENST00000370392.1_Missense_Mutation_p.R366K|KCNQ5_ENST00000370398.1_Missense_Mutation_p.R366K|KCNQ5_ENST00000355635.3_Missense_Mutation_p.R366K|KCNQ5_ENST00000355194.4_Missense_Mutation_p.R366K	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	366					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TTTGAGAAAAGAAGGAACCCA	0.398000													51	86					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049948	9049948	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9049948G>A	ENST00000397910.4	-	5	31886	c.31683C>T	c.(31681-31683)ttC>ttT	p.F10561F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10563	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATTCTCTATTGAAAACAGATG	0.483000													50	116					0	0	1	0	0
NIPSNAP1	8508	broad.mit.edu	37	22	29957530	29957530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29957530G>A	ENST00000216121.7	-	6	798	c.544C>T	c.(544-546)Ccc>Tcc	p.P182S		NM_001202502.1|NM_003634.3	NP_001189431.1|NP_003625.2	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1 (C. elegans)	182								p.?(1)		large_intestine(2)|lung(2)|skin(1)	5						TAGATGTTGGGACCCATTCTG	0.582000													33	78					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50213610	50213610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50213610G>A	ENST00000392518.4	+	15	1972	c.1600G>A	c.(1600-1602)Gcc>Acc	p.A534T	CPT1C_ENST00000323446.5_Missense_Mutation_p.A534T|CPT1C_ENST00000598293.1_Missense_Mutation_p.A534T|CPT1C_ENST00000354199.5_Missense_Mutation_p.A534T|CPT1C_ENST00000405931.2_Missense_Mutation_p.A523T	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	534					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CCTGAGGGGAGCCAAGATCTT	0.527000													10	115					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286021	48286021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48286021C>T	ENST00000320048.1	+	1	609	c.609C>T	c.(607-609)tcC>tcT	p.S203S		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						ATGGCGGCTCCATCTCCGTAG	0.547000													19	32					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179739455	179739455	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179739455G>A	ENST00000253778.8	-	15	1690	c.1521C>T	c.(1519-1521)atC>atT	p.I507I		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	507					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	AGCCACGGATGATCTCTTGCC	0.433000													30	76					0	0	1	0	0
PTRF	284119	broad.mit.edu	37	17	40557273	40557273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40557273G>A	ENST00000357037.5	-	2	1024	c.605C>T	c.(604-606)tCg>tTg	p.S202L		NM_012232.5	NP_036364.2	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	202					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CTCGTCCGACGAAAGCTCCAG	0.667000													83	109					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209791391	209791391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209791391C>T	ENST00000391911.1	-	19	3301	c.2912G>A	c.(2911-2913)aGc>aAc	p.S971N	LAMB3_ENST00000356082.4_Missense_Mutation_p.S971N|LAMB3_ENST00000367030.3_Missense_Mutation_p.S971N	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	971	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		ATGGGCTCGGCTCCTGGGTGA	0.572000													7	77					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37029580	37029580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37029580G>A	ENST00000358047.3	+	1	3149	c.3097G>A	c.(3097-3099)Gaa>Aaa	p.E1033K		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	1033										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						AGATGCATCGGAAGAAGATTA	0.393000													19	74					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41615665	41615665	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41615665G>A	ENST00000313860.7	+	7	723	c.669G>A	c.(667-669)agG>agA	p.R223R	LIMCH1_ENST00000509638.1_Silent_p.R64R|LIMCH1_ENST00000381753.4_Silent_p.R69R|LIMCH1_ENST00000513024.1_Silent_p.R64R|LIMCH1_ENST00000508501.1_Silent_p.R223R|LIMCH1_ENST00000509454.1_Silent_p.R71R|LIMCH1_ENST00000512946.1_Silent_p.R223R|LIMCH1_ENST00000509277.1_Silent_p.R69R|LIMCH1_ENST00000511496.1_Silent_p.R64R|LIMCH1_ENST00000512820.1_Silent_p.R223R|LIMCH1_ENST00000503057.1_Silent_p.R64R|LIMCH1_ENST00000512632.1_Silent_p.R223R|LIMCH1_ENST00000514096.1_Silent_p.R76R|LIMCH1_ENST00000396595.3_Silent_p.R69R	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	223					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TAGTCCTCAGGGGAAGCAGCG	0.547000													9	66					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768559	140768559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140768559C>T	ENST00000519479.1	+	1	1108	c.1108C>T	c.(1108-1110)Cgt>Tgt	p.R370C	PCDHGA7_ENST00000518325.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCAAAGTCCGTGACAAGGA	0.398000													20	77					0	0	1	0	0
BPIFA2	140683	broad.mit.edu	37	20	31761975	31761975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31761975G>A	ENST00000253362.2	+	4	539	c.393G>A	c.(391-393)gcG>gcA	p.A131A	BPIFA2_ENST00000354932.5_Silent_p.A131A			Q96DR5	SPLC2_HUMAN	BPI fold containing family A, member 2	131						extracellular region	lipid binding										CTGTCACCGCGAATGTCACTG	0.532000													28	81					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108455370	108455370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108455370G>A	ENST00000408999.3	+	4	432	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K	RGPD4_ENST00000354986.4_Missense_Mutation_p.E119K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	119					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						ATACTGGGTGGAAAGAGCAGC	0.343000													110	237					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21744103	21744103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21744103G>A	ENST00000328843.6	+	39	6377	c.6346G>A	c.(6346-6348)Gac>Aac	p.D2116N	DNAH11_ENST00000409508.3_Missense_Mutation_p.D2109N			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2116					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGTGACTGACGACATCCCAGT	0.453000									Kartagener syndrome				11	19					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113547155	113547155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113547155C>T	ENST00000416899.2	+	10	1547	c.1421C>T	c.(1420-1422)tCc>tTc	p.S474F	MUSK_ENST00000189978.5_Missense_Mutation_p.S482F|MUSK_ENST00000374438.1_Intron|MUSK_ENST00000374448.4_Missense_Mutation_p.S482F			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	482					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						CCTTCCTCCTCCTCTTCTTCC	0.403000													40	67					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113442792	113442792	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113442792C>T	ENST00000392583.2	+	7	1440	c.1233C>T	c.(1231-1233)ctC>ctT	p.L411L	OAS2_ENST00000342315.4_Silent_p.L411L|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	411	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding	p.L411L(1)		NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						ATGCCGATCTCGTCGTGTTCC	0.478000													19	52					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38185201	38185201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38185201C>T	ENST00000373048.4	-	15	2640	c.2641G>A	c.(2641-2643)Gac>Aac	p.D881N	EPHA10_ENST00000540011.1_3'UTR|EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000427468.2_Missense_Mutation_p.D881N|EPHA10_ENST00000330210.7_Missense_Mutation_p.D376N	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	881	Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGCCAGCAGTCGAGCATTAGT	0.632000													9	50					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231314955	231314955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231314955C>T	ENST00000264052.5	+	8	1160	c.805C>T	c.(805-807)Ccc>Tcc	p.P269S	SP100_ENST00000409112.1_Missense_Mutation_p.P269S|SP100_ENST00000409897.1_Missense_Mutation_p.P234S|SP100_ENST00000427101.2_Missense_Mutation_p.P244S|SP100_ENST00000409824.1_Missense_Mutation_p.P244S|SP100_ENST00000409341.1_Missense_Mutation_p.P269S|SP100_ENST00000340126.4_Missense_Mutation_p.P269S|SP100_ENST00000341950.4_Missense_Mutation_p.P269S	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	269					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CTGCCCGTTGCCCTGTGATGA	0.433000													27	81					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100385647	100385647	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100385647C>T	ENST00000542585.1	+	0	7261				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGCCCCTCCTCGTGGAAGGAC	0.557000													19	52					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237374332	237374332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237374332C>T	ENST00000409907.3	-	6	1016	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K	IQCA1_ENST00000431676.2_Missense_Mutation_p.E248K|IQCA1_ENST00000309507.5_Missense_Mutation_p.E244K			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	248							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						GCACTGACTTCATTAAAGAGA	0.418000													4	18					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111441412	111441412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111441412C>T	ENST00000265162.5	+	10	1959	c.1617C>T	c.(1615-1617)acC>acT	p.T539T		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	539					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ACACCTGGACCAGACAGATGG	0.403000													30	77					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182171	140182171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140182171C>T	ENST00000522353.2	+	1	1389	c.1389C>T	c.(1387-1389)ttC>ttT	p.F463F	PCDHA3_ENST00000532566.2_Silent_p.F463F|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACGGTGTTCGTGAAGGAGA	0.662000													19	153					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43893738	43893738	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43893738G>A	ENST00000450892.2	-	24	4634	c.4557C>T	c.(4555-4557)ccC>ccT	p.P1519P	STRC_ENST00000541030.1_Silent_p.P746P	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1519					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ATCCCCGGGGGGGACCCCACA	0.527000													21	60					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1325381	1325381	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1325381G>A	ENST00000381567.3	-	3	293	c.294C>T	c.(292-294)tcC>tcT	p.S98S	CRLF2_ENST00000381566.1_Silent_p.S98S|CRLF2_ENST00000467626.1_5'UTR	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	98						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CATTCCTGATGGAGAAATAGA	0.507000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								19	98					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383057	22383057	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22383057G>A	ENST00000328795.4	+	1	676	c.585G>A	c.(583-585)gtG>gtA	p.V195V	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTTTGTGGTGGAGCTTCTAA	0.527000													15	66					0	0	1	0	0
SERPIND1	3053	broad.mit.edu	37	22	21141196	21141196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21141196G>A	ENST00000215727.5	+	5	1625	c.1342G>A	c.(1342-1344)Gaa>Aaa	p.E448K	PI4KA_ENST00000255882.6_Intron|PI4KA_ENST00000572273.1_Intron|SERPIND1_ENST00000406799.1_Missense_Mutation_p.E448K|PI4KA_ENST00000466162.1_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	448					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	AGTGAACGAGGAAGGCACCCA	0.547000													41	115					0	0	1	0	0
APOL6	80830	broad.mit.edu	37	22	36055574	36055574	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36055574G>A	ENST00000409652.3	+	3	1239	c.963G>A	c.(961-963)agG>agA	p.R321R		NM_030641.3	NP_085144.1	Q9BWW8	APOL6_HUMAN	apolipoprotein L, 6	321					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity			haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						AGGAGTTAAGGGAGCATGTGT	0.507000													10	58					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25961910	25961910	+	Silent	SNP	G	G	A	rs139636096		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25961910G>A	ENST00000356865.6	-	9	1854	c.1743C>T	c.(1741-1743)gtC>gtT	p.V581V		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	581					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		ACGTGACGACGACTGTGTTGC	0.587000													13	150					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131864654	131864654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131864654G>A	ENST00000359827.3	-	20	4628	c.3666C>T	c.(3664-3666)tcC>tcT	p.S1222S	PLXNA4_ENST00000321063.4_Silent_p.S1222S			Q9HCM2	PLXA4_HUMAN	plexin A4	1222	IPT/TIG 4.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCATCCCCGGGGAGTACTCCA	0.647000													8	26					0	0	1	0	0
LMOD2	442721	broad.mit.edu	37	7	123302375	123302375	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123302375C>T	ENST00000458573.2	+	2	892	c.735C>T	c.(733-735)ttC>ttT	p.F245F	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	245						cytoskeleton	actin binding|tropomyosin binding										TGAAGACGTTCAGTCTGGCCA	0.498000													7	47					0	0	1	0	0
CARD10	29775	broad.mit.edu	37	22	37892456	37892456	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37892456C>T	ENST00000403299.1	-	14	2275	c.2059_splice	c.e14+1	p.A687_splice	CARD10_ENST00000406271.3_Splice_Site_p.A401_splice|CARD10_ENST00000251973.5_Splice_Site_p.A687_splice			Q9BWT7	CAR10_HUMAN	caspase recruitment domain family, member 10	687					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					CCAGACTTACCCTTCGAGTCC	0.642000													12	38					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40330368	40330368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40330368G>A	ENST00000264661.3	-	3	770	c.438C>T	c.(436-438)ggC>ggT	p.G146G	KCNH4_ENST00000607371.1_Silent_p.G146G	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	146					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGTCCCCGCGGCCTCCTTGGG	0.567000													21	22					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619175	57619175	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57619175C>T	ENST00000349394.5	+	2	747	c.572C>T	c.(571-573)cCc>cTc	p.P191L	NXPH4_ENST00000555154.1_3'UTR	NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	191	IV (linker domain).				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						GGGCTGGGGCCCCCGCTGGGG	0.756000													20	40					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51507373	51507373	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51507373G>A	ENST00000396402.1	-	8	1068	c.915C>T	c.(913-915)atC>atT	p.I305I	CYP19A1_ENST00000396404.4_Silent_p.I305I|CYP19A1_ENST00000260433.2_Silent_p.I305I|RP11-108K3.1_ENST00000559909.1_lincRNA|CYP19A1_ENST00000559878.1_Silent_p.I305I	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	305					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	CAGGAGCTGCGATCAGCATTT	0.403000													20	78					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63059013	63059013	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63059013G>A	ENST00000332793.6	+	2	406	c.402_splice	c.e2-1	p.W135_splice	SLC22A10_ENST00000544661.1_5'UTR|SLC22A10_ENST00000526800.1_Splice_Site_p.W83_splice|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	135						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTCTTCCAGTGGGACCTGGTA	0.468000													16	44					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855900	12855900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12855900C>T	ENST00000332296.7	+	4	1283	c.1180C>T	c.(1180-1182)Ctg>Ttg	p.L394L	PRAMEF1_ENST00000400814.3_Silent_p.L149L	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	394										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TATTGACGCCCTGAAGGACCT	0.552000													43	206					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34666412	34666412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34666412G>A	ENST00000488417.1	+	3	1169	c.1049G>A	c.(1048-1050)gGg>gAg	p.G350E	C1orf94_ENST00000373374.3_Missense_Mutation_p.G160E	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	160							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AAGGGTCAAGGGAGCCTCTTT	0.597000													40	89					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248813251	248813251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248813251C>T	ENST00000344889.3	-	1	934	c.935G>A	c.(934-936)gGa>gAa	p.G312E		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGTTACCTTTCCTGAGGACAC	0.428000													23	60					0	0	1	0	0
IGKV1-8	28942	broad.mit.edu	37	2	89291972	89291972	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89291972C>T	ENST00000495489.1	-	0	353																											GCAAAATCTTCAGACTGCAGG	0.478000													66	189					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488296	108488296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108488296G>A	ENST00000408999.3	+	20	3913	c.3836G>A	c.(3835-3837)aGa>aAa	p.R1279K	RGPD4_ENST00000354986.4_Missense_Mutation_p.R1279K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1279					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AGCCCTGTGAGAAAAAATCTT	0.393000													122	338					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73839265	73839265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73839265G>A	ENST00000207549.4	-	3	615	c.236C>T	c.(235-237)tCt>tTt	p.S79F	UNC13D_ENST00000587504.1_5'UTR|UNC13D_ENST00000412096.2_Missense_Mutation_p.S79F	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	79					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGCAGCTCAGAGGCCTCCGT	0.672000									Familial Hemophagocytic Lymphohistiocytosis				21	39					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31133827	31133827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31133827G>A	ENST00000349752.5	-	15	2238	c.1599C>T	c.(1597-1599)atC>atT	p.I533I	GALNT14_ENST00000420311.2_Silent_p.I498I|GALNT14_ENST00000406653.1_Silent_p.I513I|GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000356174.3_Silent_p.I500I|GALNT14_ENST00000324589.5_Silent_p.I538I	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	533	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					GGTTGACGACGATTTCCTTGC	0.557000													27	67					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390399	197390399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197390399G>A	ENST00000367400.3	+	6	1576	c.1441G>A	c.(1441-1443)Gaa>Aaa	p.E481K	CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000535699.1_Missense_Mutation_p.E412K|CRB1_ENST00000543483.1_Missense_Mutation_p.E180K|CRB1_ENST00000538660.1_Missense_Mutation_p.E481K|CRB1_ENST00000544212.1_5'UTR|CRB1_ENST00000476483.1_3'UTR|CRB1_ENST00000367399.2_Missense_Mutation_p.E369K	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	481	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GTCCCTGTGTGAAATCGCAAC	0.498000													6	73					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135386427	135386427	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:135386427C>T	ENST00000354042.4	-	7	1401		c.e7+1			NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4							integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						CGTTCTATTACCTGGGATGGG	0.512000													21	48					0	0	1	0	0
IL1RN	3557	broad.mit.edu	37	2	113890408	113890408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113890408G>A	ENST00000361779.3	+	6	737	c.392G>A	c.(391-393)gGc>gAc	p.G131D	IL1RN_ENST00000409930.3_Missense_Mutation_p.G165D|IL1RN_ENST00000409052.1_Missense_Mutation_p.G131D|IL1RN_ENST00000354115.2_Missense_Mutation_p.G147D|IL1RN_ENST00000259206.5_Missense_Mutation_p.G168D	NM_173843.2	NP_776215.1	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist	165					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	10					Anakinra(DB00026)	CCTGACGAAGGCGTCATGGTC	0.587000									Lichen Sclerosis et Atrophicus, Familial Clustering of				24	113					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41416085	41416085	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41416085C>T	ENST00000400454.1	-	31	5780	c.5303G>A	c.(5302-5304)tGg>tAg	p.W1768*		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1768					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGCAGCCTCCAGTCTGTGGT	0.617000													36	92					0	0	1	0	0
CARKD	55739	broad.mit.edu	37	13	111277611	111277611	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111277611C>T	ENST00000309957.2	+	4	386	c.372C>T	c.(370-372)atC>atT	p.I124I	CARKD_ENST00000470164.2_Intron|CARKD_ENST00000458711.2_Intron|CARKD_ENST00000424185.2_Intron|CARKD_ENST00000397191.4_Intron	NM_001242881.1|NM_018210.3	NP_001229810.1|NP_060680.2	Q8IW45	CARKD_HUMAN	carbohydrate kinase domain containing	124	YjeF C-terminal.									NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)	15						CGGAGCTGATCGTCCACCCAG	0.592000													8	31					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102067320	102067320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102067320G>A	ENST00000549145.1	+	25	2847	c.2747G>A	c.(2746-2748)aGg>aAg	p.R916K	MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000361466.2_Missense_Mutation_p.R910K|MYBPC1_ENST00000360610.2_Missense_Mutation_p.R903K|MYBPC1_ENST00000550270.1_Missense_Mutation_p.R903K|MYBPC1_ENST00000547509.1_Missense_Mutation_p.R871K|MYBPC1_ENST00000547405.1_Missense_Mutation_p.R859K|MYBPC1_ENST00000545503.2_Missense_Mutation_p.R885K|MYBPC1_ENST00000541119.1_Missense_Mutation_p.R873K|MYBPC1_ENST00000536007.1_Missense_Mutation_p.R866K|MYBPC1_ENST00000452455.2_Missense_Mutation_p.R903K|MYBPC1_ENST00000392934.3_Missense_Mutation_p.R872K|MYBPC1_ENST00000361685.2_Missense_Mutation_p.R910K|MYBPC1_ENST00000441232.1_Missense_Mutation_p.R903K|MYBPC1_ENST00000551300.1_Missense_Mutation_p.R786K|MYBPC1_ENST00000553190.1_Missense_Mutation_p.R885K			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	903	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						AAAGCAGAGAGGAGCCACTCT	0.388000													84	178					0	0	1	0	0
NFAM1	150372	broad.mit.edu	37	22	42807656	42807656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42807656G>A	ENST00000329021.5	-	2	245	c.208C>T	c.(208-210)Cca>Tca	p.P70S		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	70	Ig-like V-type.				B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			large_intestine(1)|lung(3)	4						GGAGTGTATGGATAGGTGATC	0.547000													38	65					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984100	85984100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85984100C>T	ENST00000372113.4	-	2	886	c.881G>A	c.(880-882)aGa>aAa	p.R294K	LRIT2_ENST00000538192.1_Missense_Mutation_p.R294K	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	294	Ig-like.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						ATCAAATTCTCTCCACATACT	0.512000													5	41					0	0	1	0	0
SRPX2	27286	broad.mit.edu	37	X	99925834	99925834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:99925834C>T	ENST00000373004.3	+	11	1676	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	416					angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						GCTCCTACTTCAACATGGTGT	0.522000											OREG0019890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	26					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116960640	116960640	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:116960640A>T	ENST00000265441.3	-	2	590	c.291T>A	c.(289-291)ttT>ttA	p.F97L	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	97					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GGACCCTGCCAAAAAGGCTGT	0.577000													5	17					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113346511	113346511	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113346511G>A	ENST00000452357.2	+	2	541	c.351G>A	c.(349-351)gtG>gtA	p.V117V	OAS1_ENST00000445409.2_Silent_p.V117V|OAS1_ENST00000553185.1_Silent_p.V117V|OAS1_ENST00000202917.5_Silent_p.V117V|RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000551241.1_Silent_p.V117V	NM_002534.2	NP_002525.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	117	Necessary for binding to dsRNA.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						CATTTTCCGTGAAGTTTGAGG	0.562000													14	53					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281283	49281283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:49281283C>T	ENST00000282018.3	+	1	333	c.330C>T	c.(328-330)gcC>gcT	p.A110A		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	110					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	GAGACCTGGCCTGCAGGATTA	0.453000													46	71					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56320560	56320560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56320560G>A	ENST00000443188.1	-	5	2126	c.1416C>T	c.(1414-1416)ccC>ccT	p.P472P	NLRP11_ENST00000589824.2_Silent_p.P472P|NLRP11_ENST00000592953.1_Silent_p.P373P|NLRP11_ENST00000589093.1_Silent_p.P472P|NLRP11_ENST00000360133.3_Silent_p.P472P	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	472							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGCTGCCTGAGGGGATCAGAT	0.398000													32	72					0	0	1	0	0
HSD17B3	3293	broad.mit.edu	37	9	99012059	99012059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:99012059G>A	ENST00000375263.3	-	6	510	c.463C>T	c.(463-465)Cat>Tat	p.H155Y	RP11-240L7.4_ENST00000448857.1_RNA|HSD17B3_ENST00000375262.2_Missense_Mutation_p.H155Y|HSD17B3_ENST00000464104.1_5'UTR	NM_000197.1	NP_000188.1	P37058	DHB3_HUMAN	hydroxysteroid (17-beta) dehydrogenase 3	155					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	ATGTTACAATGGATGAGGCTC	0.398000													15	52					0	0	1	0	0
FAM120C	54954	broad.mit.edu	37	X	54159224	54159224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54159224G>A	ENST00000375180.2	-	9	2019	c.1963C>T	c.(1963-1965)Cgg>Tgg	p.R655W	FAM120C_ENST00000328235.4_Missense_Mutation_p.R655W	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	655										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CGAGCTGACCGGAATAAGAGA	0.488000													9	13					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41148164	41148164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41148164G>A	ENST00000344051.4	+	9	1474	c.1240G>A	c.(1240-1242)Gaa>Aaa	p.E414K	SPINT1_ENST00000431806.1_Missense_Mutation_p.E398K|SPINT1_ENST00000562057.1_Missense_Mutation_p.E398K			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	414	BPTI/Kunitz inhibitor 2.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		CCCCTTCAGCGAACACTGCGC	0.577000													113	72					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132158506	132158506	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132158506G>A	ENST00000378679.3	-	10	3345	c.2541C>T	c.(2539-2541)ttC>ttT	p.F847F	SHROOM1_ENST00000319854.3_Silent_p.F842F|SHROOM1_ENST00000378676.1_Silent_p.F778F	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	847					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAGAAGAGGGAAGGGCGGCT	0.607000													8	17					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57334198	57334198	+	Missense_Mutation	SNP	C	C	T	rs142091870	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57334198C>T	ENST00000326441.9	-	6	851	c.488G>A	c.(487-489)cGg>cAg	p.R163Q	PEG3_ENST00000423103.2_Missense_Mutation_p.R163Q|ZIM2_ENST00000593711.1_Missense_Mutation_p.R38Q|ZIM2_ENST00000593931.1_Missense_Mutation_p.R38Q|ZIM2_ENST00000601070.1_Missense_Mutation_p.R38Q|PEG3_ENST00000593695.1_Missense_Mutation_p.R37Q|PEG3_ENST00000598410.1_Missense_Mutation_p.R38Q|ZIM2_ENST00000599935.1_Missense_Mutation_p.R38Q|ZIM2_ENST00000391708.3_Missense_Mutation_p.R38Q|ZIM2_ENST00000221722.5_Missense_Mutation_p.R38Q	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	163					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTCCCAGTCCCGGTCACCTAA	0.532000													10	16					0	0	1	0	0
POLL	27343	broad.mit.edu	37	10	103345860	103345860	+	Missense_Mutation	SNP	G	G	A	rs61757734	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103345860G>A	ENST00000370162.3	-	3	663	c.169C>T	c.(169-171)Cgg>Tgg	p.R57W	POLL_ENST00000370172.1_5'UTR|POLL_ENST00000370158.3_Intron|POLL_ENST00000339310.3_Intron|POLL_ENST00000299206.4_Missense_Mutation_p.R57W|DPCD_ENST00000470165.1_Intron|POLL_ENST00000456836.2_Intron|POLL_ENST00000436284.2_5'UTR|DPCD_ENST00000416979.2_Intron|POLL_ENST00000370169.1_Missense_Mutation_p.R57W	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	57	BRCT.				DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		AGTTCTGCCCGGGCTCGTCCA	0.537000								DNA polymerases (catalytic subunits)					18	43					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635089	33635089	+	Missense_Mutation	SNP	G	G	A	rs150287359		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33635089G>A	ENST00000380099.3	+	4	1881	c.1873G>A	c.(1873-1875)Gag>Aag	p.E625K	KL_ENST00000426690.2_3'UTR|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	625	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CATGGCCAGCGAGCTTGTCCG	0.627000													13	85					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915400	119915400	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:119915400G>A	ENST00000331113.4	+	1	1679	c.714G>A	c.(712-714)atG>atA	p.M238I		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	238					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CCTGCGTCATGATCTTCACAG	0.542000													11	44					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37454063	37454063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37454063G>A	ENST00000374660.1	+	18	1975	c.1876G>A	c.(1876-1878)Gaa>Aaa	p.E626K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E626K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E626K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	682						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GGACTATGAAGAAAATTCTTG	0.289000													41	65					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24802755	24802755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24802755C>T	ENST00000395799.3	+	6	2921	c.2792C>T	c.(2791-2793)tCt>tTt	p.S931F	TNRC6A_ENST00000315183.7_Missense_Mutation_p.S931F	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	931	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TCTAATCAGTCTCTAGGTTGG	0.468000													26	57					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2542537	2542537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2542537G>A	ENST00000358864.1	+	4	450	c.435G>A	c.(433-435)ggG>ggA	p.G145G		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	145	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						CCTCTGGTGGGGAGTCCCTGT	0.617000													24	64					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89525033	89525033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89525033C>T	ENST00000370473.4	-	4	614	c.395G>A	c.(394-396)gGa>gAa	p.G132E		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	132					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GTTGATGGTTCCTATGCTATT	0.527000													43	158					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458979	45458979	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45458979C>T	ENST00000548424.1	+	0	448																											CCTTGTATTTCCCCAGCTCAT	0.433000													12	28					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55976645	55976645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55976645C>T	ENST00000263923.4	-	9	1475	c.1180G>A	c.(1180-1182)Gga>Aga	p.G394R		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	394	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTGTAATTTCCTGTGTCTCTT	0.408000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			31	59					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179535006	179535006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179535006C>T	ENST00000589042.1	-	157	35549	c.35325G>A	c.(35323-35325)aaG>aaA	p.K11775K	TTN_ENST00000342992.6_Silent_p.K10474K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.K11401K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9894	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACAATTTTCTTAGGCACCT	0.313000													5	14					0	0	1	0	0
ART1	417	broad.mit.edu	37	11	3681454	3681454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3681454C>T	ENST00000250693.1	+	3	806	c.705C>T	c.(703-705)ttC>ttT	p.F235F		NM_004314.2	NP_004305.2	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1	235					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|skin(1)	8		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	ACTCCTTCTTCCCTGGAGAGG	0.612000													34	64					0	0	1	0	0
HACE1	57531	broad.mit.edu	37	6	105198317	105198317	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:105198317G>A	ENST00000262903.4	-	20	2518	c.2242C>T	c.(2242-2244)Cga>Tga	p.R748*	HACE1_ENST00000369125.2_Nonsense_Mutation_p.R533*|HACE1_ENST00000517995.1_5'UTR	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	748	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		CTTGTCATTCGAAGTTCAGTA	0.348000													14	20					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125874326	125874326	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125874326G>A	ENST00000393434.2	-	5	898	c.549C>T	c.(547-549)atC>atT	p.I183I	ALDH1L1_ENST00000273450.3_Silent_p.I193I|ALDH1L1_ENST00000393431.2_Silent_p.I183I|ALDH1L1_ENST00000472186.1_Silent_p.I183I|ALDH1L1_ENST00000452905.2_Intron|ALDH1L1_ENST00000455064.2_Silent_p.I8I|ALDH1L1_ENST00000413612.1_5'UTR	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	183	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TGCCCTCAGCGATCAGCCTCA	0.627000													17	37					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60751500	60751500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60751500G>A	ENST00000303375.5	+	9	1940	c.1538G>A	c.(1537-1539)gGg>gAg	p.G513E		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	513					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						CTGAGCCAGGGGGCCGCCGAG	0.637000													3	2					0	0	1	0	0
HRH2	3274	broad.mit.edu	37	5	175111263	175111263	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:175111263C>T	ENST00000231683.2	+	1	2800	c.1027C>T	c.(1027-1029)Cag>Tag	p.Q343*	HRH2_ENST00000377291.2_Nonsense_Mutation_p.Q343*	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	343					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CCTGAAGCTCCAGGTGTGGAG	0.597000													45	132					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113538641	113538641	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113538641G>A	ENST00000505019.1	-	6	2682	c.2557C>T	c.(2557-2559)Cag>Tag	p.Q853*	C4orf21_ENST00000309071.5_Nonsense_Mutation_p.Q853*|C4orf21_ENST00000445203.2_Nonsense_Mutation_p.Q822*	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	853										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GTTCCTTGCTGAAAGACAGTA	0.348000													24	77					0	0	1	0	0
FABP3	2170	broad.mit.edu	37	1	31840289	31840289	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:31840289C>T	ENST00000373713.2	-	3	360	c.299G>A	c.(298-300)gGg>gAg	p.G100E	FABP3_ENST00000497275.1_5'UTR	NM_004102.3	NP_004093.1	P05413	FABPH_HUMAN	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	100					negative regulation of cell proliferation					large_intestine(1)|lung(2)|ovary(2)	5		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0185)|READ - Rectum adenocarcinoma(331;0.149)		GGTCTCTTGCCCGTCCCATTT	0.473000													81	193					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142180806	142180806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142180806G>A	ENST00000350721.4	-	42	7289	c.7168C>T	c.(7168-7170)Ctg>Ttg	p.L2390L	ATR_ENST00000383101.3_Silent_p.L2326L	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2390	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						AGTTTGGTCAGAATAGGTCTC	0.303000								Other conserved DNA damage response genes					71	227					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964551	119964551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119964551G>A	ENST00000543831.1	+	4	676	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	HSD3B2_ENST00000369416.3_Missense_Mutation_p.E143K	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	143					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CGGCCACGAAGAAGAGCCTCT	0.527000													32	146					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156635978	156635978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156635978C>T	ENST00000422843.3	+	2	369	c.217C>T	c.(217-219)Cca>Tca	p.P73S	CTB-4E7.1_ENST00000519375.1_RNA	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	73	PH.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCAGCATCCCATGCCACTA	0.498000			T	SYK	peripheral T-cell lymphoma								4	54					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4432135	4432135	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4432135C>T	ENST00000301280.5	+	12	2235	c.2134C>T	c.(2134-2136)Ctg>Ttg	p.L712L	CHAF1A_ENST00000587368.1_3'UTR	NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	712	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCCTGCTTCCTGGAGACCCT	0.662000								Chromatin Structure					12	44					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153660163	153660163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153660163G>A	ENST00000368680.3	+	14	2618	c.2146G>A	c.(2146-2148)Ggc>Agc	p.G716S		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	716	Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CCCTGTGCGGGGCTCCCAGGC	0.597000													43	125					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132529451	132529451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:132529451C>T	ENST00000333577.4	+	38	6954	c.6845C>T	c.(6844-6846)cCt>cTt	p.P2282L	EP400_ENST00000332482.4_Missense_Mutation_p.P2209L|EP400_ENST00000389562.2_Missense_Mutation_p.P2245L|EP400_ENST00000389561.2_Missense_Mutation_p.P2246L|EP400_ENST00000330386.6_Missense_Mutation_p.P2165L			Q96L91	EP400_HUMAN	E1A binding protein p400	2282					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		AAGCTGCCCCCTGTGTACGTG	0.627000													27	45					0	0	1	0	0
FAM81A	145773	broad.mit.edu	37	15	59799517	59799517	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:59799517G>A	ENST00000288228.5	+	5	706	c.519G>A	c.(517-519)acG>acA	p.T173T		NM_152450.2	NP_689663.2	Q8TBF8	FA81A_HUMAN	family with sequence similarity 81, member A	173										endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10						TCTTGGAAACGAAAATCAAAG	0.433000													4	23					0	0	1	0	0
NOX1	27035	broad.mit.edu	37	X	100105173	100105173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:100105173C>T	ENST00000372966.3	-	9	1305	c.1100G>A	c.(1099-1101)aGg>aAg	p.R367K	NOX1_ENST00000217885.5_Missense_Mutation_p.R367K|NOX1_ENST00000372960.4_Missense_Mutation_p.R330K|NOX1_ENST00000372964.1_Intron	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	367	FAD-binding FR-type.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						TTCGAAAGCCCTTATGAGATT	0.473000													13	25					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19319212	19319212	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:19319212G>A	ENST00000461366.1	+	14	1835	c.1620G>A	c.(1618-1620)acG>acA	p.T540T		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	540							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						ACTCCTACACGATGCGCTTCT	0.657000													17	18					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72407608	72407608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72407608G>A	ENST00000359373.5	-	23	4109	c.3258C>T	c.(3256-3258)atC>atT	p.I1086I	ARAP1_ENST00000334211.8_Silent_p.I841I|ARAP1_ENST00000393609.3_Silent_p.I1086I|ARAP1_ENST00000455638.2_Silent_p.I1086I|ARAP1_ENST00000429686.1_Silent_p.I780I|ARAP1_ENST00000426523.1_Silent_p.I841I|ARAP1_ENST00000393605.3_Silent_p.I846I|ARAP1_ENST00000495878.1_5'UTR			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	1086	Rho-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						ACAGGTGGCTGATAAGGGCCT	0.602000													14	46					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136294	40136294	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:40136294G>A	ENST00000278198.2	-	2	3512	c.1549C>T	c.(1549-1551)Cca>Tca	p.P517S	LRRC4C_ENST00000530763.1_Missense_Mutation_p.P517S|LRRC4C_ENST00000528697.1_Missense_Mutation_p.P517S|LRRC4C_ENST00000527150.1_Missense_Mutation_p.P517S			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	517					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				TCAATTCCTGGGATCCCACTG	0.473000													24	32					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140167471	140167471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140167471G>A	ENST00000458420.3	+	6	1088	c.898G>A	c.(898-900)Gag>Aag	p.E300K		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	300					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GATCGTCACAGAGCTGCAGAC	0.527000										HNSCC(16;0.037)			40	111					0	0	1	0	0
POMT2	29954	broad.mit.edu	37	14	77778331	77778331	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77778331G>A	ENST00000261534.4	-	2	496	c.294C>T	c.(292-294)aaC>aaT	p.N98N		NM_013382.5	NP_037514.2	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	98					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		AAAATGTACGGTTGATATAGT	0.418000													8	55					0	0	1	0	0
SPAG7	9552	broad.mit.edu	37	17	4864138	4864138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4864138G>A	ENST00000575142.1	-	2	81	c.63C>T	c.(61-63)gcC>gcT	p.A21A	SPAG7_ENST00000573366.1_5'UTR|SPAG7_ENST00000206020.3_Silent_p.A32A			O75391	SPAG7_HUMAN	sperm associated antigen 7	32						nucleus	nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(3)|ovary(2)|urinary_tract(1)	10						TCTTCAGGCGGGCGGCCTGTT	0.502000													26	62					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83362658	83362658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:83362658G>A	ENST00000262752.2	-	13	1091	c.1084C>T	c.(1084-1086)Cct>Tct	p.P362S	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.P362S	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	362	AGC-kinase C-terminal.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						GTAAATTCAGGATCAAAACAA	0.303000													11	18					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65241864	65241864	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65241864G>A	ENST00000389722.3	-	22	4874	c.4821C>T	c.(4819-4821)gtC>gtT	p.V1607V	SPTB_ENST00000389720.3_Silent_p.V1607V|SPTB_ENST00000389721.5_Silent_p.V1607V|SPTB_ENST00000556626.1_Silent_p.V1607V|SPTB_ENST00000542895.1_Silent_p.V1607V	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1607					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CATCGGAGATGACGTAGAGCT	0.622000													15	136					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990959	39990959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39990959C>T	ENST00000332312.3	-	4	1442	c.1250G>A	c.(1249-1251)gGg>gAg	p.G417E		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	417						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				AAGCTCATCCCCGGCCGGGGC	0.642000													7	106					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24411015	24411015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24411015C>T	ENST00000330966.7	-	16	2078	c.1916G>A	c.(1915-1917)cGg>cAg	p.R639Q	MYOM3_ENST00000374434.3_Missense_Mutation_p.R638Q|MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Missense_Mutation_p.R638Q|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	638	Fibronectin type-III 3.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CCCCACCTTCCGGGAGTAGAT	0.512000													20	174					0	0	1	0	0
SPATA31A2	642265	broad.mit.edu	37	9	39888172	39888172	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:39888172G>A	ENST00000456183.2	+	4	1188	c.1159G>A	c.(1159-1161)Gag>Aag	p.E387K		NM_001040065.1	NP_001035154.1			SPATA31 subfamily A, member 2																		GAACATGGGAGAGAACTCGAA	0.478000													45	42					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48615797	48615797	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48615797C>T	ENST00000328333.8	-	64	5596	c.5487_splice	c.e64-1	p.G1830_splice	COL7A1_ENST00000454817.1_Splice_Site_p.G1830_splice	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1830	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCTGGCTTTCCCTGTGGGAA	0.562000													28	76					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124381320	124381320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124381320G>A	ENST00000287394.5	-	8	1134	c.1027C>T	c.(1027-1029)Cct>Tct	p.P343S	ATAD2_ENST00000534257.1_5'UTR|ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TTACAGTAAGGACTTCTTGGT	0.403000													22	44					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3351177	3351177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3351177C>T	ENST00000520002.1	-	12	1974	c.1419G>A	c.(1417-1419)ggG>ggA	p.G473G	CSMD1_ENST00000542608.1_Silent_p.G472G|CSMD1_ENST00000539096.1_Silent_p.G472G|CSMD1_ENST00000537824.1_Silent_p.G472G|CSMD1_ENST00000602723.1_Silent_p.G473G|CSMD1_ENST00000400186.3_Silent_p.G473G|CSMD1_ENST00000602557.1_Silent_p.G473G			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	473	CUB 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCCCACCTTCCCAGCATCAC	0.507000													12	8					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155761161	155761161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155761161G>A	ENST00000159060.2	-	6	699	c.597C>T	c.(595-597)tcC>tcT	p.S199S		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	199	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		ACAACTCATAGGAGGCCTGTC	0.507000													27	38					0	0	1	0	0
ZNF461	92283	broad.mit.edu	37	19	37130142	37130142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37130142G>A	ENST00000588268.1	-	6	1332	c.1105C>T	c.(1105-1107)Cgc>Tgc	p.R369C	ZNF461_ENST00000360357.4_Missense_Mutation_p.R346C|ZNF461_ENST00000540605.2_5'UTR	NM_153257.2	NP_694989.2	Q8TAF7	ZN461_HUMAN	zinc finger protein 461	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGATGTGAGCGATGCCTAAAA	0.418000													25	62					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101865215	101865215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101865215C>T	ENST00000348070.1	-	18	2213	c.2214G>A	c.(2212-2214)ggG>ggA	p.G738G	PCSK6_ENST00000561177.1_5'UTR|PCSK6_ENST00000358417.3_Silent_p.G725G	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	739	CRM (Cys-rich motif).				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTGCTGTGTCCCCAAAGTAGC	0.657000													26	23					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12336400	12336400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12336400C>T	ENST00000358136.3	+	19	2885	c.2755C>T	c.(2755-2757)Ccc>Tcc	p.P919S	VPS13D_ENST00000356315.4_Missense_Mutation_p.P919S	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	919					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAAGATTTTTCCCCAGGAGGA	0.438000											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	42					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854285	12854285	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12854285G>A	ENST00000332296.7	+	3	612	c.509G>A	c.(508-510)tGg>tAg	p.W170*		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	170								p.W170L(2)		cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTTCCAGTGGGTTTACCAA	0.433000													49	636					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451962	138451962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138451962C>T	ENST00000344876.4	-	1	1667	c.1281G>A	c.(1279-1281)aaG>aaA	p.K427K	PCDH18_ENST00000412923.2_Silent_p.K427K|PCDH18_ENST00000507846.1_Silent_p.K207K|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	427	Cadherin 4.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ACTCAGATCTCTTTTCTCTAT	0.353000													44	111					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366642	248366642	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248366642C>T	ENST00000456743.1	+	1	311	c.273C>T	c.(271-273)tcC>tcT	p.S91S		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S91S(1)		endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCAGCAAGTCCATTTCTATGG	0.498000													156	394					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926512	157926512	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157926512C>T	ENST00000389413.3	-	9	1516	c.1413G>A	c.(1411-1413)ggG>ggA	p.G471G	PTPRN2_ENST00000389416.4_Silent_p.G454G|PTPRN2_ENST00000404321.2_Silent_p.G494G|PTPRN2_ENST00000389418.4_Silent_p.G471G|PTPRN2_ENST00000409483.1_Silent_p.G433G	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	471						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TTTGGAGCTCCCCAAACGCAG	0.637000													25	71					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233335967	233335967	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233335967G>A	ENST00000258229.8	-	14	3141	c.2907C>T	c.(2905-2907)ttC>ttT	p.F969F	PCNXL2_ENST00000488780.2_Silent_p.F102F	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	969						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TGATTTGCGGGAAGAGCCCAA	0.398000													9	10					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68192613	68192613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68192613G>A	ENST00000294304.7	+	15	3386	c.3280G>A	c.(3280-3282)Gaa>Aaa	p.E1094K		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1094	Beta-propeller 4.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AGCCAAGATCGAACGCGCAGC	0.657000													13	65					0	0	1	0	0
C12orf77	196415	broad.mit.edu	37	12	25148783	25148783	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25148783T>A	ENST00000549828.1	-	3	569	c.365A>T	c.(364-366)aAa>aTa	p.K122I	C12orf77_ENST00000434912.3_Missense_Mutation_p.K67I|C12orf77_ENST00000549262.1_Missense_Mutation_p.K67I	NM_001101339.1	NP_001094809.1	C9JDV5	CL097_HUMAN	chromosome 12 open reading frame 77	122										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	7						TGGGTTTCTTTTTGTAAAGTC	0.408000													20	40					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118624248	118624248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:118624248C>T	ENST00000336338.5	-	14	1845	c.1780G>A	c.(1780-1782)Gaa>Aaa	p.E594K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	594						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CGTTCTACTTCATTCCAGCTC	0.458000													31	102					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133789762	133789762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:133789762C>T	ENST00000367895.5	+	11	1327	c.863C>T	c.(862-864)tCa>tTa	p.S288L	EYA4_ENST00000355167.3_Missense_Mutation_p.S288L|EYA4_ENST00000452339.2_Missense_Mutation_p.S234L|EYA4_ENST00000430974.2_Missense_Mutation_p.S234L|EYA4_ENST00000355286.6_Missense_Mutation_p.S265L|EYA4_ENST00000531901.1_Missense_Mutation_p.S288L|EYA4_ENST00000431403.2_Missense_Mutation_p.S288L|EYA4_ENST00000525849.1_Missense_Mutation_p.S265L	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	288					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TATTCAGCATCAACGTATGGA	0.413000													47	68					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120172084	120172084	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120172084G>A	ENST00000392521.2	-	26	3290	c.3235C>T	c.(3235-3237)Cta>Tta	p.L1079L	CIT_ENST00000261833.7_Silent_p.L1037L|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1037					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCTTTTTCTAGCAGCTCATCG	0.542000													23	74					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20634834	20634834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20634834G>A	ENST00000219151.4	-	14	1871	c.661C>T	c.(661-663)Cgg>Tgg	p.R221W	ACSM1_ENST00000520010.1_Missense_Mutation_p.R570W|ACSM1_ENST00000307493.4_Missense_Mutation_p.R570W			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	570					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TCCTTTTTCCGAAGTTCCTTC	0.488000													30	63					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248684977	248684977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248684977G>A	ENST00000343414.4	+	1	62	c.30G>A	c.(28-30)aaG>aaA	p.K10K		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTCTGAAAAGGGATTTCTTC	0.413000													34	162					0	0	1	0	0
FGGY	55277	broad.mit.edu	37	1	59844489	59844489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:59844489G>A	ENST00000371218.4	+	5	718	c.534G>A	c.(532-534)aaG>aaA	p.K178K	FGGY_ENST00000303721.7_Silent_p.K178K|FGGY_ENST00000474476.1_3'UTR|FGGY_ENST00000371212.1_Silent_p.K90K	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	178					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					TATCGTGGAAGGCAACAGGTG	0.383000													29	82					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52603771	52603771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52603771C>T	ENST00000395489.2	-	6	586	c.190G>A	c.(190-192)Gag>Aag	p.E64K	A1CF_ENST00000373993.1_Missense_Mutation_p.E71K|A1CF_ENST00000282641.2_Missense_Mutation_p.E71K|A1CF_ENST00000373997.3_Missense_Mutation_p.E71K|A1CF_ENST00000374001.1_Missense_Mutation_p.E71K|A1CF_ENST00000395495.1_Missense_Mutation_p.E71K|A1CF_ENST00000373995.3_Missense_Mutation_p.E79K	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	71	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GGTATAAGCTCATCCTCAAAA	0.388000													51	169					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	629674	629674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:629674C>T	ENST00000255622.6	+	3	670	c.627C>T	c.(625-627)ttC>ttT	p.F209F	PDE6B_ENST00000496514.1_Silent_p.F209F	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	209	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						TTCAGGTGTTCTTGAAGTACC	0.507000													17	48					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202777349	202777349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202777349G>A	ENST00000367265.3	-	1	1249	c.85C>T	c.(85-87)Cca>Tca	p.P29S	KDM5B_ENST00000367264.2_Missense_Mutation_p.P29S	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	29					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						CACTCGGGTGGAGGCAGGAAC	0.706000													22	42					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488815	20488815	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20488815C>T	ENST00000555186.1	+	0	298					NR_038836.1																						ATGTGGAACCCCCACCTGCTT	0.428000													17	132					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187542685	187542685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187542685G>A	ENST00000441802.2	-	10	5264	c.5055C>T	c.(5053-5055)ttC>ttT	p.F1685F		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1685	Cadherin 15.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CCATCCCAACGAAACTCCCAA	0.388000										HNSCC(5;0.00058)			24	76					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72324627	72324627	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72324627C>T	ENST00000389916.4	+	2	241	c.103C>T	c.(103-105)Cat>Tat	p.H35Y		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	35	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CCTCATCGCCCATAAAGTGGA	0.627000													4	12					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18257561	18257561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18257561G>A	ENST00000286479.3	+	2	155	c.48G>A	c.(46-48)agG>agA	p.R16R	NAT2_ENST00000520116.1_Intron	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	16					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		AGAACTCTAGGAACAAATTGG	0.378000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				68	150					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4920518	4920518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4920518C>T	ENST00000433855.1	+	1	2177	c.1311C>T	c.(1309-1311)atC>atT	p.I437I	KCNA6_ENST00000280684.3_Silent_p.I437I	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	437						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GGGGAAAGATCGTGGGCTCGC	0.592000										HNSCC(72;0.22)			25	69					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70071222	70071222	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70071222C>T	ENST00000370598.1	+	29	4878	c.4057C>T	c.(4057-4059)Ccc>Tcc	p.P1353S	BAI3_ENST00000546190.1_Missense_Mutation_p.P317S|BAI3_ENST00000238918.8_Missense_Mutation_p.P559S	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1353					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CAATATGAATCCCCCTGTAAT	0.423000													7	109					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439538	52439538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52439538G>A	ENST00000242819.4	+	2	320	c.24G>A	c.(22-24)ctG>ctA	p.L8L		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	8						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CATTCCGGCTGATAAGGAAGA	0.572000													30	58					0	0	1	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919888	142919888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142919888G>A	ENST00000408947.3	+	1	759	c.717G>A	c.(715-717)atG>atA	p.M239I		NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	239					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					ACCCCAGCATGAAGGCTCACA	0.498000													45	141					0	0	1	0	0
UGT1A6	54578	broad.mit.edu	37	2	234601708	234601708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234601708C>T	ENST00000305139.6	+	1	197	c.58C>T	c.(58-60)Ctt>Ttt	p.L20F	UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron	NM_001072.3	NP_001063.2														central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CTTCTTAGCACTTTGGGGCAT	0.483000													24	87					0	0	1	0	0
RNF145	153830	broad.mit.edu	37	5	158609049	158609049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:158609049G>A	ENST00000424310.2	-	4	663	c.304C>T	c.(304-306)Cgg>Tgg	p.R102W	RNF145_ENST00000521606.2_Missense_Mutation_p.R119W|RNF145_ENST00000520638.1_Missense_Mutation_p.R116W|RNF145_ENST00000518802.1_Missense_Mutation_p.R132W|RNF145_ENST00000519865.1_Missense_Mutation_p.R102W|RNF145_ENST00000274542.2_Missense_Mutation_p.R130W	NM_001199383.1	NP_001186312.1	Q96MT1	RN145_HUMAN	ring finger protein 145	102						integral to membrane	zinc ion binding			endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTTCACTCCGAACATAGTCC	0.318000													31	133					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56467057	56467057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56467057C>T	ENST00000291971.3	+	3	1704	c.1633C>T	c.(1633-1635)Ccc>Tcc	p.P545S	NLRP8_ENST00000590542.1_Missense_Mutation_p.P545S	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	545						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GATAGCGAGTCCCAGAGGAAG	0.458000													43	85					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6712357	6712357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6712357C>T	ENST00000245907.6	-	11	1272	c.1180G>A	c.(1180-1182)Gag>Aag	p.E394K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	394					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACAGTGTCCTCGCCCTGGACT	0.617000													21	48					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141600242	141600242	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141600242G>A	ENST00000442267.2	-	5	779	c.705C>T	c.(703-705)ttC>ttT	p.F235F		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	235						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TGATGTTGAGGAATACAGAGA	0.478000													58	157					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923060	24923060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24923060G>A	ENST00000329468.2	+	1	2520	c.2046G>A	c.(2044-2046)gtG>gtA	p.V682V		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCACTTTAGTGAACAGTGCCT	0.522000													67	187					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71027107	71027107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:71027107G>A	ENST00000318789.4	-	15	1745	c.1220C>T	c.(1219-1221)cCa>cTa	p.P407L	FOXP1_ENST00000468577.1_Missense_Mutation_p.P407L|FOXP1_ENST00000475937.1_Missense_Mutation_p.P407L|FOXP1_ENST00000493089.1_Missense_Mutation_p.P407L|FOXP1_ENST00000498215.1_Missense_Mutation_p.P407L|FOXP1_ENST00000484350.1_Missense_Mutation_p.P331L|FOXP1_ENST00000491238.1_Missense_Mutation_p.P409L	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	407					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TGGGGTCGTTGGAGTATGAGG	0.557000			T	PAX5	ALL								13	156					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46628458	46628458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46628458C>T	ENST00000470495.1	-	2	1981	c.534G>A	c.(532-534)ggG>ggA	p.G178G	HOXB-AS1_ENST00000502764.2_RNA|HOXB3_ENST00000498678.1_Silent_p.G178G|HOXB3_ENST00000476342.1_Silent_p.G178G|HOXB3_ENST00000472863.1_Silent_p.G105G|HOXB3_ENST00000490677.1_Silent_p.G44G|HOXB3_ENST00000311626.4_Silent_p.G178G|HOXB3_ENST00000460160.1_Silent_p.G46G|HOXB3_ENST00000489475.1_Silent_p.G105G|HOXB3_ENST00000485909.2_Silent_p.G46G|HOXB-AS1_ENST00000435312.1_RNA|HOXB-AS3_ENST00000465846.2_RNA			P14651	HXB3_HUMAN	homeobox B3	178	Gly-rich.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						GGCTCTTGTCCCCTCCCccgc	0.756000													22	20					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68812269	68812269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68812269C>T	ENST00000508048.1	-	2	64	c.29G>A	c.(28-30)cGa>cAa	p.R10Q	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.R11Q|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.R11Q			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	11					cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity	p.R11Q(1)		breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						ATTTCTGCTTCGGGTGCCAAA	0.488000													21	45					0	0	1	0	0
CHST1	8534	broad.mit.edu	37	11	45671526	45671526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:45671526G>A	ENST00000308064.2	-	4	1618	c.948C>T	c.(946-948)atC>atT	p.I316I		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	316					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GGAACCCGTAGATCTCCTCGG	0.642000													31	51					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32792919	32792919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32792919C>T	ENST00000380250.3	+	36	5212	c.4716C>T	c.(4714-4716)ctC>ctT	p.L1572L		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACACTCGCCTCGAGTCAAGAT	0.413000													11	47					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79024751	79024751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79024751G>A	ENST00000446378.2	+	2	194	c.163G>A	c.(163-165)Gat>Aat	p.D55N		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	55	Glu-rich.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ATCAGACCAGGATGAAGAGGG	0.323000													17	31					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21958140	21958140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21958140G>A	ENST00000261201.4	-	38	4617	c.4618C>T	c.(4618-4620)Ctc>Ttc	p.L1540F	ABCC9_ENST00000261200.4_Intron|ABCC9_ENST00000345162.2_Missense_Mutation_p.L1504F	NM_005691.2	NP_005682.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1540	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTGGAAAAGAGGCCATTCTTG	0.423000													19	34					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18657708	18657708	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18657708G>A	ENST00000380548.4	+	8	1245	c.906G>A	c.(904-906)agG>agA	p.R302R	ADAMTSL1_ENST00000327883.7_Silent_p.R302R|ADAMTSL1_ENST00000276935.6_Silent_p.R302R|ADAMTSL1_ENST00000380566.4_Silent_p.R302R	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	302						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		ACCGATGGAGGGAGACGGATT	0.463000													8	38					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59113756	59113756	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:59113756C>T	ENST00000395153.3	+	4	2451	c.2304C>T	c.(2302-2304)ccC>ccT	p.P768P	DACT1_ENST00000335867.4_Silent_p.P805P|DACT1_ENST00000556859.1_Silent_p.P524P|DACT1_ENST00000395151.3_Silent_p.P524P|DACT1_ENST00000541264.2_Silent_p.P524P	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	805					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						ACAACCACCCCGCAAAAACCT	0.502000													30	99					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20850797	20850797	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20850797G>A	ENST00000262715.5	-	28	4165	c.4125C>T	c.(4123-4125)ttC>ttT	p.F1375F	TEP1_ENST00000556935.1_Silent_p.F1267F	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1375	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CATACAGCGTGAAGAGCCTCA	0.552000													29	70					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57161729	57161729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57161729G>A	ENST00000371244.4	+	6	751	c.685G>A	c.(685-687)Ggt>Agt	p.G229S		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	229	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						GATCCGAGGGGGTGTCTTTTA	0.443000													38	345					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24448111	24448111	+	Missense_Mutation	SNP	C	C	T	rs146993893	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24448111C>T	ENST00000230036.1	-	17	1782	c.1672G>A	c.(1672-1674)Gac>Aac	p.D558N		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	558						extracellular region	glycosylphosphatidylinositol phospholipase D activity	p.D558N(1)		breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						CTACCTTTGTCGCTCAGGCTG	0.522000													16	31					0	0	1	0	0
SENP1	29843	broad.mit.edu	37	12	48457594	48457594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48457594G>A	ENST00000004980.5	-	13	1784	c.1306C>T	c.(1306-1308)Cgt>Tgt	p.R436C	SENP1_ENST00000549518.1_Missense_Mutation_p.R436C|SENP1_ENST00000448372.1_Missense_Mutation_p.R436C|SENP1_ENST00000339976.6_3'UTR|SENP1_ENST00000551330.1_Missense_Mutation_p.R436C|SENP1_ENST00000549595.1_Missense_Mutation_p.R436C			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	436					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				TTCCCATTACGAAATACATTC	0.383000													10	37					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151804206	151804206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151804206G>A	ENST00000318247.6	-	1	142	c.35C>T	c.(34-36)tCa>tTa	p.S12L	RORC_ENST00000392697.3_5'UTR	NM_005060.3	NP_005051.2	P51449	RORG_HUMAN	RAR-related orphan receptor C	12	Modulating (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTTACCCCGTGAGGCTCGGTG	0.662000													19	171					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42414957	42414957	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42414957C>T	ENST00000381668.5	-	37	3702	c.3471G>A	c.(3469-3471)acG>acA	p.T1157T	ATP8A1_ENST00000264449.10_Silent_p.T1142T	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	1157					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity	p.T1157T(1)		NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	GCCTCTGTTTCGTGGTATCAT	0.458000													17	46					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138683650	138683650	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138683650G>A	ENST00000298480.5	+	31	3647	c.3573G>A	c.(3571-3573)atG>atA	p.M1191I	KCNT1_ENST00000487664.1_Missense_Mutation_p.M1146I|KCNT1_ENST00000491806.2_Missense_Mutation_p.M1156I|KCNT1_ENST00000371757.2_Missense_Mutation_p.M1170I|KCNT1_ENST00000490355.2_Missense_Mutation_p.M1169I|KCNT1_ENST00000263604.3_Missense_Mutation_p.M1165I|KCNT1_ENST00000488444.2_Missense_Mutation_p.M1170I|KCNT1_ENST00000486577.2_Missense_Mutation_p.M1148I			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	1170						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CAGACGAGATGAACGACCACC	0.647000													30	103					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681066	142681066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142681066G>A	ENST00000340634.3	-	1	1112	c.1113C>T	c.(1111-1113)tcC>tcT	p.S371S		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	371						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						TGCAGAATTCGGAGCTGTTTA	0.527000													41	127					0	0	1	0	0
SUSD1	64420	broad.mit.edu	37	9	114874094	114874094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114874094G>A	ENST00000374270.3	-	8	1183	c.1011C>T	c.(1009-1011)gaC>gaT	p.D337D	SUSD1_ENST00000374264.2_Silent_p.D337D|SUSD1_ENST00000374263.3_Silent_p.D337D	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1	337						integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						ATTCCATAGGGTCCAACCGTT	0.507000													22	48					0	0	1	0	0
BCL2L10	10017	broad.mit.edu	37	15	52404827	52404827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52404827C>T	ENST00000260442.3	-	1	145	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	BCL2L10_ENST00000561198.1_Missense_Mutation_p.E33K	NM_020396.2	NP_065129.1	Q9HD36	B2L10_HUMAN	BCL2-like 10 (apoptosis facilitator)	23					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2				all cancers(107;0.0148)		GTGCCGGGTTCCCGGGCGCAG	0.716000													3	5					0	0	1	0	0
RBM33	155435	broad.mit.edu	37	7	155567726	155567726	+	Silent	SNP	C	C	T	rs139259621		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:155567726C>T	ENST00000401878.3	+	18	3702	c.3504C>T	c.(3502-3504)atC>atT	p.I1168I	RBM33_ENST00000341148.3_Silent_p.I104I	NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	1168	RRM.						nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		TGGCCCTGATCGTGGAGTGAG	0.502000													14	42					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10315987	10315987	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10315987G>A	ENST00000403437.2	-	13	1300	c.1206C>T	c.(1204-1206)ctC>ctT	p.L402L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	402	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TAGGGTAGCAGAGGGCTTTGA	0.502000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				96	142					0	0	1	0	0
CCP110	9738	broad.mit.edu	37	16	19547601	19547601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19547601C>T	ENST00000396212.2	+	5	1046	c.610C>T	c.(610-612)Ccc>Tcc	p.P204S	CCP110_ENST00000396208.2_Missense_Mutation_p.P204S|CCP110_ENST00000381396.5_Missense_Mutation_p.P204S	NM_014711.4	NP_055526.3	O43303	CP110_HUMAN	centriolar coiled coil protein 110kDa	204	CEP97 binding.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|stomach(3)|urinary_tract(1)	21						TTCTGATGGTCCCTTCTCAGT	0.393000													57	111					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78372553	78372553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78372553C>T	ENST00000278550.7	-	33	7954	c.7492G>A	c.(7492-7494)Gaa>Aaa	p.E2498K		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TAGGAGGGTTCCATGGCATCC	0.532000													9	13					0	0	1	0	0
S100A8	6279	broad.mit.edu	37	1	153362973	153362973	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153362973G>A	ENST00000368733.3	-	2	208	c.39C>T	c.(37-39)atC>atT	p.I13I	S100A8_ENST00000477801.1_5'UTR|S100A8_ENST00000368732.1_Silent_p.I13I	NM_002964.4	NP_002955.2	P05109	S10A8_HUMAN	S100 calcium binding protein A8	13	EF-hand 1.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGTAGACGTCGATGATAGAGT	0.498000													68	146					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27238925	27238925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27238925G>A	ENST00000222753.4	-	1	800	c.772C>T	c.(772-774)Ctc>Ttc	p.L258F	HOTTIP_ENST00000421733.1_RNA	NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	258					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						GGGCCCCCGAGGCCCGGCACC	0.657000			T	NUP98	AML								13	31					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101834561	101834561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101834561C>T	ENST00000263468.8	+	6	3065	c.2795C>T	c.(2794-2796)cCc>cTc	p.P932L	KIAA1377_ENST00000537689.1_Missense_Mutation_p.P733L	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	932							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAATCAGTTCCCTTATGGAAA	0.378000													49	114					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125621386	125621386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125621386C>T	ENST00000316519.6	+	17	2063	c.1857C>T	c.(1855-1857)ctC>ctT	p.L619L	AACS_ENST00000545511.1_Intron|AACS_ENST00000316543.10_Silent_p.L217L|AACS_ENST00000261686.6_Intron|AACS_ENST00000543665.1_Intron	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	619					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		TGCCCAGCCTCATCCTGGAAA	0.632000													20	44					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21225438	21225438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21225438C>T	ENST00000233242.1	-	29	12983	c.12856G>A	c.(12856-12858)Gcc>Acc	p.A4286T		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4286					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACTGAATGGCTTTAAATACC	0.348000													45	114					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6521818	6521818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6521818G>A	ENST00000377782.3	-	10	1024	c.957C>T	c.(955-957)ccC>ccT	p.P319P	TNFRSF25_ENST00000348333.3_Silent_p.P265P|TNFRSF25_ENST00000356876.3_Silent_p.P310P|TNFRSF25_ENST00000351748.3_Silent_p.P127P|TNFRSF25_ENST00000351959.5_Silent_p.P273P	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	310					apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GCGCAGCAGCGGGGCCTGGGG	0.716000													3	1					0	0	1	0	0
FRK	2444	broad.mit.edu	37	6	116288845	116288845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116288845G>A	ENST00000606080.1	-	4	1114	c.668C>T	c.(667-669)aCc>aTc	p.T223I	FRK_ENST00000538210.1_Missense_Mutation_p.T81I	NM_002031.2	NP_002022.1	P42685	FRK_HUMAN	fyn-related kinase	223					negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|skin(1)|urinary_tract(1)	27		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TTGGTCCACGGTTTTATACGA	0.388000													36	57					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51752037	51752037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51752037G>A	ENST00000543196.2	-	8	1582	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	GALNT6_ENST00000356317.3_Silent_p.F459F			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	459					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						AAATGTCACCGAAGGATTTCT	0.473000													44	117					0	0	1	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84872160	84872160	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84872160C>T	ENST00000262424.5	+	2	283	c.59C>T	c.(58-60)tCc>tTc	p.S20F	CRISPLD2_ENST00000564567.1_Missense_Mutation_p.S20F|CRISPLD2_ENST00000566431.1_3'UTR|CRISPLD2_ENST00000567845.1_Missense_Mutation_p.S20F|CRISPLD2_ENST00000569090.1_Missense_Mutation_p.S20F	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	20						extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						GTCTGCGGATCCCAAGGCTAC	0.617000													30	86					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157494322	157494322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157494322G>A	ENST00000361835.3	-	10	2143	c.1986C>T	c.(1984-1986)acC>acT	p.T662T	FCRL5_ENST00000356953.4_Silent_p.T662T|FCRL5_ENST00000368190.3_Silent_p.T662T|FCRL5_ENST00000368191.3_Silent_p.T577T	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	662	Ig-like C2-type 7.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GAGCCCTGAAGGTGAGGATGG	0.507000													22	38					0	0	1	0	0
OR11H1	81061	broad.mit.edu	37	22	16449127	16449127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:16449127G>A	ENST00000252835.4	-	1	678	c.678C>T	c.(676-678)ttC>ttT	p.F226F		NM_001005239.1	NP_001005239.1	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H, member 1	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)	11	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		TAATAAAGAGGAAGTTACCAA	0.433000													56	119					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44102468	44102468	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44102468C>T	ENST00000259746.9	+	2	330	c.147C>T	c.(145-147)ttC>ttT	p.F49F	TMEM63B_ENST00000323267.6_Silent_p.F49F			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	49						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTCTCGACTTCATGTGCTTCC	0.607000													27	66					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176016169	176016169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176016169C>T	ENST00000510636.1	+	22	3268	c.2994C>T	c.(2992-2994)ttC>ttT	p.F998F	CDHR2_ENST00000261944.5_Silent_p.F998F|CDHR2_ENST00000506348.1_Silent_p.F998F	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	998	Cadherin 9.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CCGACGTGTTCGCTGGGAGCA	0.612000													60	162					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247752561	247752561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247752561G>A	ENST00000320065.1	+	1	900	c.900G>A	c.(898-900)gtG>gtA	p.V300V	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCAAGGAGGTGAAAGGGGCAT	0.368000													52	152					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99551856	99551856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:99551856G>A	ENST00000373034.4	-	6	4541	c.2866C>T	c.(2866-2868)Cat>Tat	p.H956Y	PCDH19_ENST00000255531.7_Missense_Mutation_p.H909Y|PCDH19_ENST00000420881.2_Missense_Mutation_p.H908Y	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	956					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.H956Y(1)|p.H409Y(1)		breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						TCCCGGCAATGAAATCCTTCA	0.473000													30	23					0	0	1	0	0
SF3B4	10262	broad.mit.edu	37	1	149899118	149899118	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149899118G>A	ENST00000271628.8	-	2	687	c.103C>T	c.(103-105)Cag>Tag	p.Q35*		NM_005850.4	NP_005841.1	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4, 49kDa	35	RRM 1.					nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			endometrium(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)	17	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GGTCCAGCCTGGAGAAACAGT	0.562000													15	83					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54805731	54805731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54805731C>T	ENST00000293379.4	-	2	497	c.236G>A	c.(235-237)gGa>gAa	p.G79E	ITGA5_ENST00000547744.1_5'UTR|RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	79					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CTTGGGTGCTCCCACCAGCAC	0.602000													11	25					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211521331	211521331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211521331C>T	ENST00000233072.5	+	30	3837	c.3641C>T	c.(3640-3642)aCc>aTc	p.T1214I	CPS1_ENST00000451903.2_Missense_Mutation_p.T763I|CPS1_ENST00000430249.2_Missense_Mutation_p.T1220I	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1214	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCCACACAAACCATCAGCCAA	0.403000													18	69					0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123664559	123664559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123664559C>T	ENST00000542236.1	+	3	1893	c.1512C>T	c.(1510-1512)ctC>ctT	p.L504L	BBS12_ENST00000314218.3_Silent_p.L504L	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	504					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						CGGCCGTGCTCACTAACCCAG	0.408000									Bardet-Biedl syndrome				31	97					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57420500	57420500	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57420500C>T	ENST00000543257.1	-	5	802	c.235_splice	c.e5-1	p.G79_splice	C8B_ENST00000371237.4_Splice_Site_p.G131_splice|C8B_ENST00000535057.1_Splice_Site_p.G69_splice	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	131	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TACACACCTTCCTAGAATGGA	0.433000													17	86					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169656259	169656259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169656259C>T	ENST00000428432.2	+	9	1695	c.1306C>T	c.(1306-1308)Cct>Tct	p.P436S	SAMD7_ENST00000335556.3_Missense_Mutation_p.P436S	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	436										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TACAATAATTCCTAAAGGAAT	0.398000													9	32					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8656696	8656696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8656696G>A	ENST00000595838.1	-	2	290	c.257C>T	c.(256-258)cCt>cTt	p.P86L	ADAMTS10_ENST00000597188.1_Silent_p.S595S|ADAMTS10_ENST00000270328.4_Silent_p.S595S			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	0					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CCGTGTTGCAGGAGCGGTGCC	0.612000													24	105					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56189956	56189956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56189956C>T	ENST00000340462.4	-	3	700	c.420G>A	c.(418-420)acG>acA	p.T140T	ZBP1_ENST00000343535.4_Silent_p.T163T|ZBP1_ENST00000371173.3_Silent_p.T163T|ZBP1_ENST00000541799.1_Silent_p.T163T|ZBP1_ENST00000395822.3_Silent_p.T88T			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	163						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GGCGGTAAATCGTCCATGCTT	0.552000													50	128					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167747817	167747817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167747817G>A	ENST00000470487.1	-	10	1873	c.1184C>T	c.(1183-1185)cCt>cTt	p.P395L	GOLIM4_ENST00000309027.4_Missense_Mutation_p.P367L	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	395	Glu-rich.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTTGGCTGAAGGGTACACCTA	0.522000													31	60					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32893986	32893986	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32893986G>A	ENST00000330048.5	-	0	1271					NR_003083.2																						GGCCACATGTGGCCCAGGGCA	0.567000													9	76					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62049186	62049186	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62049186G>A	ENST00000578147.1	-	4	583	c.507C>T	c.(505-507)acC>acT	p.T169T	SCN4A_ENST00000435607.1_Silent_p.T169T			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	169					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GGGACTCAAAGGTGTAGATCC	0.592000													8	23					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184103895	184103895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184103895C>T	ENST00000204604.1	+	15	2126	c.1880C>T	c.(1879-1881)gCc>gTc	p.A627V	CHRD_ENST00000348986.3_Missense_Mutation_p.A587V|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000545352.1_Missense_Mutation_p.A257V|CHRD_ENST00000450923.1_Missense_Mutation_p.A627V	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	627	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AAAGGCATGGCCTCCCTGATG	0.617000													29	80					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202710505	202710505	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202710505G>T	ENST00000367265.3	-	19	4099	c.2935C>A	c.(2935-2937)Ctc>Atc	p.L979I	KDM5B_ENST00000367264.2_Missense_Mutation_p.L1015I	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	979					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						CTGGCCTTGAGGAGACTCTTG	0.522000													17	47					9.16793e-09	9.20044e-09	1	1	0
NKX2-2	4821	broad.mit.edu	37	20	21492959	21492959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:21492959C>T	ENST00000377142.4	-	2	780	c.424G>A	c.(424-426)Gag>Aag	p.E142K		NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	142					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						CGCTCCAGCTCGTAGGTCTGC	0.677000													8	22					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183655757	183655757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183655757G>A	ENST00000334444.6	-	26	4026	c.3786C>T	c.(3784-3786)ggC>ggT	p.G1262G	ABCC5_ENST00000265586.6_Silent_p.G1219G	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1262	ABC transporter 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GGTCGGCAAGGCCAATATCAC	0.547000													34	75					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188507	140188507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140188507G>A	ENST00000530339.1	+	1	1735	c.1735G>A	c.(1735-1737)Gag>Aag	p.E579K	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.E579K|PCDHA4_ENST00000512229.2_Missense_Mutation_p.E579K|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCAGTGAGCGAGCTGGTGCC	0.662000													19	75					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78717428	78717428	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:78717428G>A	ENST00000436010.2	-	11	2535	c.1538C>T	c.(1537-1539)cCa>cTa	p.P513L	ROBO1_ENST00000495273.1_Missense_Mutation_p.P516L|ROBO1_ENST00000464233.1_Missense_Mutation_p.P552L|ROBO1_ENST00000467549.1_Missense_Mutation_p.P516L			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	552	Ig-like C2-type 5.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AGTAGGTCTTGGAGGCTGAAC	0.388000													39	114					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531154	50531154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50531154C>T	ENST00000374144.3	+	3	852	c.564C>T	c.(562-564)ttC>ttT	p.F188F	C10orf71_ENST00000323868.4_Silent_p.F188F			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	188										endometrium(1)	1						ACTTCTGCTTCGATTCTGCCT	0.547000													10	36					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22927561	22927561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22927561G>A	ENST00000166244.3	+	15	2781	c.2709G>A	c.(2707-2709)agG>agA	p.R903R		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	903						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AGAGTCTCAGGGCCACCGCCA	0.637000													25	45					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23117572	23117572	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23117572G>A	ENST00000219689.7	-	4	914	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	305					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		AAATGCAAAGGAAAGGATCAA	0.383000													19	59					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121061450	121061450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121061450C>T	ENST00000392793.1	+	24	6674	c.6403C>T	c.(6403-6405)Ctt>Ttt	p.L2135F	TECTA_ENST00000264037.2_Missense_Mutation_p.L2135F			O75443	TECTA_HUMAN	tectorin alpha	2135					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix		p.L2135delL(1)	TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGTCTGGACGCTTCTTCTCAT	0.383000													15	32					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183995769	183995769	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183995769C>T	ENST00000402825.3	+	5	889	c.889C>T	c.(889-891)Cta>Tta	p.L297L	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000357474.5_Silent_p.L225L|ECE2_ENST00000404464.3_Silent_p.L179L|ECE2_ENST00000359140.4_Silent_p.L150L	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	297	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCGCTTCTACCTATCTTGCCT	0.557000													28	63					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145109543	145109543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145109543G>A	ENST00000426825.1	-	19	2688	c.2607C>T	c.(2605-2607)ccC>ccT	p.P869P	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	869							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	TGGTGGAGTGGGGGGGCATGG	0.642000													6	39					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238223	104238223	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104238223G>A	ENST00000374851.1	-	4	2299	c.1152C>T	c.(1150-1152)ctC>ctT	p.L384L	TMEM246_ENST00000374848.3_Silent_p.L384L|RP11-490D19.6_ENST00000424154.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000450109.1_RNA|TMEM246_ENST00000374847.1_Silent_p.L384L			Q9BRR3	CI125_HUMAN	transmembrane protein 246	384						integral to membrane											TGTGTTTCACGAGGTTCGGCT	0.542000													33	53					0	0	1	0	0
CHODL	140578	broad.mit.edu	37	21	19638318	19638318	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:19638318C>T	ENST00000338326.3	+	5	1073	c.559C>T	c.(559-561)Caa>Taa	p.Q187*	CHODL_ENST00000400131.1_Nonsense_Mutation_p.Q187*|CHODL_ENST00000299295.2_Missense_Mutation_p.S262L|CHODL_ENST00000400128.1_Missense_Mutation_p.S221L|CHODL_ENST00000400127.1_Missense_Mutation_p.S221L|CHODL_ENST00000400135.1_Nonsense_Mutation_p.Q187*|CHODL_ENST00000543733.1_Missense_Mutation_p.S243L			Q9H9P2	CHODL_HUMAN	chondrolectin	0					muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		CTGTGGATTTCAAAGAGTACC	0.323000													27	62					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183053786	183053786	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:183053786C>T	ENST00000435564.1	-	11	1375	c.1173_splice	c.e11-1	p.G392_splice	PDE1A_ENST00000346717.4_Splice_Site_p.G358_splice|PDE1A_ENST00000358139.2_Splice_Site_p.G392_splice|PDE1A_ENST00000331935.6_Splice_Site_p.G392_splice|PDE1A_ENST00000456212.1_Splice_Site_p.G392_splice|PDE1A_ENST00000536095.1_Splice_Site_p.G288_splice|PDE1A_ENST00000410103.1_Splice_Site_p.G392_splice|PDE1A_ENST00000409365.1_Splice_Site_p.G376_splice|PDE1A_ENST00000351439.5_Splice_Site_p.G376_splice	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	392	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.G392E(2)|p.G392V(2)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTCTTTATCTCCCTGGAGAAA	0.393000													41	101					0	0	1	0	0
SERPINA11	256394	broad.mit.edu	37	14	94914801	94914801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94914801C>T	ENST00000334708.3	-	2	375	c.311G>A	c.(310-312)gGa>gAa	p.G104E	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	104					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		GAGGTTGAATCCCAGGCCCTC	0.587000													41	90					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1240646	1240646	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1240646G>A	ENST00000324642.3	+	7	969	c.845_splice	c.e7-1	p.R282_splice	SLC6A18_ENST00000296821.4_Splice_Site_p.R277_splice	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	282					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.R282R(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TTGTGCCCAGGAATGACTGCC	0.587000													21	36					0	0	1	0	0
NXT1	29107	broad.mit.edu	37	20	23334836	23334836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23334836C>T	ENST00000254998.2	+	2	545	c.158C>T	c.(157-159)tCa>tTa	p.S53L		NM_013248.2	NP_037380.1	Q9UKK6	NXT1_HUMAN	NTF2-like export factor 1	53	NTF2.					cytoplasm|nuclear pore				NS(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	6	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					AATGCTGTTTCAGGACAAGAA	0.507000													29	55					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871921	51871921	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51871921G>A	ENST00000371497.5	+	2	2811	c.1924G>A	c.(1924-1926)Gaa>Aaa	p.E642K	TSHZ2_ENST00000329613.6_Missense_Mutation_p.E639K|TSHZ2_ENST00000603338.2_Missense_Mutation_p.E639K	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	642					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AACACCTCCAGAAGCCAAAAA	0.557000													31	68					0	0	1	0	0
WDR75	84128	broad.mit.edu	37	2	190327291	190327291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:190327291C>T	ENST00000314761.4	+	9	920	c.860C>T	c.(859-861)cCg>cTg	p.P287L		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	287						nucleolus		p.P287Q(2)		breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			GAGTTTCTCCCGCGTTTAGGA	0.428000													50	115					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73464832	73464832	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73464832G>A	ENST00000224721.6	+	24	2918	c.2913G>A	c.(2911-2913)gtG>gtA	p.V971V	CDH23_ENST00000299366.7_Silent_p.V1011V	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	966	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						TGCGGGTGGTGGCCAGTGATG	0.662000													27	40					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57430866	57430866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57430866G>A	ENST00000442789.2	-	21	2352	c.2065C>T	c.(2065-2067)Ctc>Ttc	p.L689F	MYO1A_ENST00000300119.3_Missense_Mutation_p.L689F|MYO1A_ENST00000544473.1_Missense_Mutation_p.L527F	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	689					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TGTTCTTCGAGGTAGAAAAGC	0.572000													21	89					0	0	1	0	0
SH2D7	646892	broad.mit.edu	37	15	78393813	78393813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78393813C>T	ENST00000328828.5	+	5	1218	c.1218C>T	c.(1216-1218)atC>atT	p.I406I	SH2D7_ENST00000409568.2_Silent_p.I270I	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	406										endometrium(2)|kidney(2)|lung(3)	7						ACAAGAGGATCTCAGGGACCC	0.592000													6	24					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104641701	104641701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104641701G>A	ENST00000315264.7	+	11	2537	c.2159G>A	c.(2158-2160)gGa>gAa	p.G720E	KIF26A_ENST00000423312.2_Missense_Mutation_p.G859E			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	859					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GGTCCCTCAGGAGGTCCAGGT	0.711000													9	18					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65623883	65623883	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65623883C>T	ENST00000327987.4	-	8	1514	c.1263G>A	c.(1261-1263)gaG>gaA	p.E421E	IGDCC3_ENST00000559231.1_5'UTR	NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	421										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CGGGGAGCCCCTCAGCCCACA	0.617000													9	29					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196709907	196709907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196709907C>T	ENST00000367429.4	+	18	3181	c.2941C>T	c.(2941-2943)Cct>Tct	p.P981S		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	981	Sushi 16.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						ATGGTCTCACCCTCCATCATG	0.343000													18	66					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186944231	186944231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186944231C>T	ENST00000337774.5	-	12	1908	c.1519G>A	c.(1519-1521)Gac>Aac	p.D507N		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	507	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CTGAGCAAGTCTGAATCACGT	0.572000													3	12					0	0	1	0	0
PNP	4860	broad.mit.edu	37	14	20943237	20943237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20943237C>T	ENST00000361505.5	+	5	624	c.478C>T	c.(478-480)Cct>Tct	p.P160S	RP11-203M5.8_ENST00000554678.1_lincRNA	NM_000270.3	NP_000261.2	P00491	PNPH_HUMAN	purine nucleoside phosphorylase	160					immune response|inosine catabolic process|interleukin-2 secretion|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide riboside catabolic process|positive regulation of alpha-beta T cell differentiation|positive regulation of T cell proliferation|purine base metabolic process|purine nucleotide catabolic process|purine-containing compound salvage|response to drug|urate biosynthetic process	cytoskeleton|cytosol	drug binding|nucleoside binding|phosphate binding|purine base binding|purine-nucleoside phosphorylase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|stomach(2)	10					Aciclovir(DB00787)|Cladribine(DB00242)|Mercaptopurine(DB01033)	AGATCGTTTCCCTGCCATGTC	0.473000													18	36					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062169	9062169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9062169C>T	ENST00000397910.4	-	3	25480	c.25277G>A	c.(25276-25278)aGg>aAg	p.R8426K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8428	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGCTGATCCTCTCAGAGCT	0.507000													39	70					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54142292	54142292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:54142292C>T	ENST00000265572.3	-	4	1005	c.708G>A	c.(706-708)gtG>gtA	p.V236V	OPRK1_ENST00000520287.1_Silent_p.V236V|OPRK1_ENST00000524278.1_Silent_p.V147V|RP11-162D9.3_ENST00000524425.1_RNA	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	236					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GGACAGGGATCACGAAGGCAA	0.532000													18	51					0	0	1	0	0
EFCAB11	90141	broad.mit.edu	37	14	90420996	90420996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90420996G>A	ENST00000316738.7	-	1	37	c.9C>T	c.(7-9)ttC>ttT	p.F3F	EFCAB11_ENST00000267544.9_5'UTR|EFCAB11_ENST00000556609.1_Intron|EFCAB11_ENST00000538485.2_Silent_p.F3F|RP11-33N16.3_ENST00000555070.1_RNA	NM_145231.2	NP_660274.1	Q9BUY7	EFC11_HUMAN	EF-hand calcium binding domain 11	3							calcium ion binding			large_intestine(1)|lung(1)	2						TGGCCTCGGAGAAGAACATCG	0.652000													3	21					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995647	19995647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:19995647G>A	ENST00000391403.2	-	1	2231	c.2128C>T	c.(2128-2130)Cca>Tca	p.P710S		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	710	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GGTGGACCTGGGACATCCCTT	0.522000													33	95					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150868515	150868515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150868515C>T	ENST00000370353.3	+	3	445	c.55C>T	c.(55-57)Cgt>Tgt	p.R19C	PRRG3_ENST00000370354.1_Missense_Mutation_p.R27C|PRRG3_ENST00000538575.1_Missense_Mutation_p.R19C			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	19						extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					ACGATTCCCTCGTGCCAATGA	0.582000													27	17					0	0	1	0	0
SOHLH1	402381	broad.mit.edu	37	9	138587048	138587048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138587048G>A	ENST00000298466.5	-	6	783	c.723C>T	c.(721-723)ccC>ccT	p.P241P	SOHLH1_ENST00000425225.1_Silent_p.P241P	NM_001012415.2	NP_001012415.2	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic helix-loop-helix 1	241					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(5)|prostate(1)	12		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		GCCAGGACAGGGGTGGCCTCA	0.692000													4	13					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3547941	3547941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3547941C>T	ENST00000355415.2	-	4	911	c.742G>A	c.(742-744)Gag>Aag	p.E248K	MFSD12_ENST00000398558.4_Missense_Mutation_p.E248K|MFSD12_ENST00000389395.3_Missense_Mutation_p.E248K|MFSD12_ENST00000591878.1_5'UTR|AC005786.7_ENST00000589360.1_RNA	NM_174983.3	NP_778148.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	248					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						CCTGGCTCCTCCGCATGCGGC	0.701000													7	17					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24930354	24930354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:24930354C>T	ENST00000405141.1	+	14	2726	c.2015C>T	c.(2014-2016)tCa>tTa	p.S672L	NCOA1_ENST00000538539.1_Missense_Mutation_p.S672L|NCOA1_ENST00000406961.1_Missense_Mutation_p.S672L|NCOA1_ENST00000395856.3_Missense_Mutation_p.S672L|NCOA1_ENST00000407230.1_Missense_Mutation_p.S521L|NCOA1_ENST00000348332.3_Missense_Mutation_p.S672L|NCOA1_ENST00000288599.5_Missense_Mutation_p.S672L			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	672	Ser-rich.								PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTAACTCTTCAGGAGGTTCT	0.488000			T	PAX3	alveolar rhadomyosarcoma								31	89					0	0	1	0	0
SLC4A2	6522	broad.mit.edu	37	7	150768843	150768843	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150768843C>T	ENST00000485713.1	+	15	3299	c.2259C>T	c.(2257-2259)gtC>gtT	p.V753V	SLC4A2_ENST00000310317.5_Silent_p.V671V|SLC4A2_ENST00000461735.1_Silent_p.V739V|SLC4A2_ENST00000413384.2_Silent_p.V753V|SLC4A2_ENST00000392826.2_Silent_p.V744V	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	753	Membrane (anion exchange).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGCGTGGTCTTCTGCCTGC	0.622000													41	106					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62782792	62782792	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62782792G>A	ENST00000582986.1	-	0	2257					NR_024386.1																						CATGCTGGGAGGCAAATTCAA	0.542000													5	20					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013235	73013235	+	Silent	SNP	C	C	T	rs145038184	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73013235C>T	ENST00000308744.6	+	4	1373	c.1275C>T	c.(1273-1275)ttC>ttT	p.F425F	NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000395999.1_Silent_p.F326F|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000358749.3_Silent_p.F323F	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	425					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GGCTGGCATTCGGCAACAGCA	0.463000													43	100					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187542889	187542889	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187542889G>A	ENST00000441802.2	-	10	5060	c.4851C>T	c.(4849-4851)ggC>ggT	p.G1617G		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1617	Cadherin 14.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTTTAATAGAGCCCAAGACAG	0.368000										HNSCC(5;0.00058)			6	16					0	0	1	0	0
SHROOM4	57477	broad.mit.edu	37	X	50345793	50345793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50345793G>A	ENST00000376020.2	-	7	3807	c.3782C>T	c.(3781-3783)tCg>tTg	p.S1261L	SHROOM4_ENST00000289292.7_Missense_Mutation_p.S1261L|SHROOM4_ENST00000460112.3_Missense_Mutation_p.S1145L	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1261	ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding	p.S1261L(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					TGAAGGAGGCGAAAAGTGCTG	0.458000													17	13					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588639	20588639	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20588639C>T	ENST00000428453.1	-	0	4111																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GTTCATTCTTCTTATAAATAA	0.413000													21	56					0	0	1	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784909	30784909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30784909G>A	ENST00000246229.4	-	3	1101	c.837C>T	c.(835-837)gcC>gcT	p.A279A		NM_002657.3	NP_002648.1	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	279						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|liver(1)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CGTCCCGAGAGGCCATGCACA	0.592000													19	51					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11364849	11364849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:11364849G>A	ENST00000304623.8	-	8	1520	c.1331C>T	c.(1330-1332)cCt>cTt	p.P444L	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Missense_Mutation_p.P11L|CTNND2_ENST00000511377.1_Missense_Mutation_p.P353L|CTNND2_ENST00000503622.1_Missense_Mutation_p.P107L|CTNND2_ENST00000359640.2_Missense_Mutation_p.P444L	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	444					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGGCGGCAGAGGGTCCCCCTG	0.642000													14	26					0	0	1	0	0
TBX3	6926	broad.mit.edu	37	12	115109849	115109849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:115109849G>A	ENST00000349155.2	-	7	2932	c.1969C>T	c.(1969-1971)Ctg>Ttg	p.L657L	TBX3_ENST00000257566.3_Silent_p.L677L	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	677	Transcription repression.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CTGGCGGCCAGGGCGGCGACT	0.716000													4	5					0	0	1	0	0
TMEM255B	348013	broad.mit.edu	37	13	114498180	114498180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:114498180C>T	ENST00000375353.3	+	4	339	c.312C>T	c.(310-312)atC>atT	p.I104I		NM_182614.2	NP_872420.1			transmembrane protein 255B																		GCTGCGCCATCGTGGACGGCG	0.527000													10	37					0	0	1	0	0
MVP	9961	broad.mit.edu	37	16	29856018	29856018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29856018C>T	ENST00000357402.5	+	11	1977	c.1839C>T	c.(1837-1839)ggC>ggT	p.G613G	MVP_ENST00000395353.1_Silent_p.G613G	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	613					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						AAGCGAAGGGCCCCGATGGCA	0.627000													52	122					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43680255	43680255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43680255C>T	ENST00000404580.1	-	3	564	c.476G>A	c.(475-477)aGg>aAg	p.R159K	PSG5_ENST00000366175.3_Missense_Mutation_p.R159K|PSG5_ENST00000407356.1_Missense_Mutation_p.R159K|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000342951.6_Missense_Mutation_p.R159K|PSG5_ENST00000599812.1_Missense_Mutation_p.R252K			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	159	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				CTTATTCTCCCTGGGTTTTGA	0.493000													112	261					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10696209	10696209	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:10696209G>A	ENST00000302079.6	-	43	6713	c.6714C>T	c.(6712-6714)ctC>ctT	p.L2238L	PIEZO2_ENST00000538948.1_Silent_p.L195L|PIEZO2_ENST00000285141.4_Silent_p.L93L|PIEZO2_ENST00000580640.1_Silent_p.L2263L|PIEZO2_ENST00000503781.3_Silent_p.L2238L			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2238						integral to membrane	ion channel activity										CAAACTGAATGAGGACCATCA	0.512000													20	53					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38607954	38607954	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38607954G>A	ENST00000413689.1	-	21	3979	c.3786C>T	c.(3784-3786)ggC>ggT	p.G1262G	SCN5A_ENST00000423572.2_Silent_p.G1261G|SCN5A_ENST00000425664.1_Silent_p.G1262G|SCN5A_ENST00000455624.2_Silent_p.G1261G|SCN5A_ENST00000450102.2_Silent_p.G1208G|SCN5A_ENST00000449557.2_Silent_p.G1208G|SCN5A_ENST00000414099.2_Silent_p.G1262G|SCN5A_ENST00000451551.2_Silent_p.G1208G|SCN5A_ENST00000333535.4_Silent_p.G1262G|SCN5A_ENST00000443581.1_Silent_p.G1261G	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1262			G -> S (in BRS1).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACTTCTTGAAGCCGTAGGCCA	0.532000													14	138					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75902057	75902057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:75902057C>T	ENST00000322507.8	-	4	514	c.205G>A	c.(205-207)Gaa>Aaa	p.E69K	COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_Missense_Mutation_p.E69K|COL12A1_ENST00000416123.2_Missense_Mutation_p.E69K	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	69	Fibronectin type-III 1.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AGGGTAAATTCTTTAGTAGGC	0.328000													8	56					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8188819	8188819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8188819C>T	ENST00000600128.1	-	23	3219	c.2805G>A	c.(2803-2805)cgG>cgA	p.R935R	FBN3_ENST00000601739.1_Silent_p.R935R|FBN3_ENST00000270509.2_Silent_p.R935R			Q75N90	FBN3_HUMAN	fibrillin 3	935	TB 5.		R -> L.			proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AGACGTCCATCCGGTACTTGC	0.647000													13	33					0	0	1	0	0
SNX24	28966	broad.mit.edu	37	5	122343382	122343382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:122343382C>T	ENST00000261369.4	+	7	633	c.448C>T	c.(448-450)Cca>Tca	p.P150S	SNX24_ENST00000513881.1_3'UTR|SNX24_ENST00000395451.4_Missense_Mutation_p.P183S	NM_014035.2	NP_054754.1	Q9Y343	SNX24_HUMAN	sorting nexin 24	150					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			lung(5)	5		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		ttCAGATTTTCCAAATGTGGT	0.333000													39	79					0	0	1	0	0
MB	4151	broad.mit.edu	37	22	36007060	36007060	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36007060C>T	ENST00000397326.2	-	2	387	c.189G>A	c.(187-189)aaG>aaA	p.K63K	MB_ENST00000406324.1_Silent_p.K63K|MB_ENST00000401702.1_Silent_p.K8K|MB_ENST00000397328.1_Silent_p.K63K|MB_ENST00000359787.1_Silent_p.K63K	NM_005368.2	NP_005359.1	P02144	MYG_HUMAN	myoglobin	63							heme binding|oxygen transporter activity			lung(1)	1						CACCATGCTTCTTTAAGTCCT	0.547000													18	91					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768050	57768050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57768050C>T	ENST00000371030.2	+	1	1976	c.1976C>T	c.(1975-1977)cCt>cTt	p.P659L		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	659						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CTGGGCTTTCCTCTGCAGAAA	0.582000													20	63					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5041989	5041989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:5041989C>T	ENST00000251170.7	+	6	805	c.625C>T	c.(625-627)Cgt>Tgt	p.R209C		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	209						integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						CCACGGGCCCCGTAGCACCCT	0.697000													5	6					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3417829	3417829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3417829G>A	ENST00000356575.4	-	19	2584	c.2358C>T	c.(2356-2358)tgC>tgT	p.C786C	MEGF6_ENST00000294599.4_Silent_p.C681C	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	786	EGF-like 13.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GGCATGCTGGGCAGATCTCCT	0.677000													10	17					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469290	72469290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:72469290C>T	ENST00000296776.5	+	1	269	c.220C>T	c.(220-222)Ctt>Ttt	p.L74F	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	74						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		GACCCAGCTCCTTGGGCCCGT	0.512000													11	105					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20135715	20135715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:20135715C>T	ENST00000395530.2	+	5	2313	c.2105C>T	c.(2104-2106)cCt>cTt	p.P702L	AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000261503.5_Missense_Mutation_p.P783L|SPECC1_ENST00000395527.4_Missense_Mutation_p.P783L|SPECC1_ENST00000584527.1_Missense_Mutation_p.P201L|SPECC1_ENST00000536879.1_Missense_Mutation_p.P123L|SPECC1_ENST00000472876.1_3'UTR|SPECC1_ENST00000395529.3_Missense_Mutation_p.P783L|SPECC1_ENST00000395522.2_Missense_Mutation_p.P702L|SPECC1_ENST00000395525.3_Missense_Mutation_p.P702L	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	783						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		AGAGCCGCCCCTCCGTGAGTC	0.612000													5	7					0	0	1	0	0
PNMA2	10687	broad.mit.edu	37	8	26365908	26365908	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:26365908G>A	ENST00000522362.2	-	3	1258	c.364C>T	c.(364-366)Cga>Tga	p.R122*		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	122					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		cccagggctcgaaacataccc	0.527000													25	67					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540727	55540727	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55540727C>T	ENST00000220676.1	+	4	4433	c.4285C>T	c.(4285-4287)Cag>Tag	p.Q1429*		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1429					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGAAGTTTCAGGATGAAAA	0.368000													24	59					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219553448	219553448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219553448C>T	ENST00000295709.3	+	12	1688	c.1409C>T	c.(1408-1410)tCc>tTc	p.S470F	STK36_ENST00000392106.2_Missense_Mutation_p.S470F|STK36_ENST00000440309.1_Missense_Mutation_p.S470F|STK36_ENST00000392105.3_Missense_Mutation_p.S470F	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	470					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GAGGGTGCTTCCCACATCCTG	0.517000													88	204					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47560332	47560332	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47560332G>A	ENST00000334194.3	+	7	870	c.867G>A	c.(865-867)ttG>ttA	p.L289L		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	289						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						ACATACTTTTGAGTGCCAAAG	0.398000													17	51					0	0	1	0	0
DDX58	23586	broad.mit.edu	37	9	32500834	32500834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32500834G>A	ENST00000379883.2	-	2	367	c.210C>T	c.(208-210)ttC>ttT	p.F70F	DDX58_ENST00000542096.1_5'UTR|DDX58_ENST00000379882.1_Intron|DDX58_ENST00000545044.1_5'UTR|DDX58_ENST00000379868.1_5'UTR	NM_014314.3	NP_055129.2	O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	70	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		AAAAGCCACGGAACCAGCCTT	0.443000													43	74					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72295967	72295967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72295967G>A	ENST00000579490.1	+	6	1141	c.1006G>A	c.(1006-1008)Gag>Aag	p.E336K	DNAI2_ENST00000582036.1_Missense_Mutation_p.E279K|DNAI2_ENST00000446837.2_Missense_Mutation_p.E279K|DNAI2_ENST00000307504.5_Missense_Mutation_p.E136K|DNAI2_ENST00000311014.6_Missense_Mutation_p.E279K			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	279					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GACGGGCACCGAGTGCTTCTC	0.617000									Kartagener syndrome				15	40					0	0	1	0	0
CSH1	1442	broad.mit.edu	37	17	61972439	61972439	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61972439G>A	ENST00000316193.8	-	5	738	c.597C>T	c.(595-597)gtC>gtT	p.V199V	CSH1_ENST00000453363.3_Silent_p.V104V|CSH1_ENST00000329882.8_3'UTR	NM_001317.5	NP_001308.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 (placental lactogen)	199					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			central_nervous_system(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						GGAATGTCTCGACCTTGTCCA	0.572000									Russell-Silver syndrome				16	164					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198651	20198651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20198651C>T	ENST00000400331.5	-	5	1641	c.1333G>A	c.(1333-1335)Gaa>Aaa	p.E445K	MACC1_ENST00000589011.1_Missense_Mutation_p.E445K|MACC1_ENST00000332878.4_Missense_Mutation_p.E445K	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	445					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						GTCTTTACTTCAAAATCAGGA	0.353000													16	69					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140991028	140991028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140991028C>T	ENST00000277549.5	+	37	5338	c.2769C>T	c.(2767-2769)ttC>ttT	p.F923F	CACNA1B_ENST00000277551.2_Silent_p.F1729F|CACNA1B_ENST00000371372.1_Silent_p.F1729F|CACNA1B_ENST00000371363.1_Silent_p.F1727F|CACNA1B_ENST00000371365.2_Silent_p.F93F|CACNA1B_ENST00000371355.4_Silent_p.F1730F|CACNA1B_ENST00000371357.1_Silent_p.F1728F			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1729					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGGATGAGTTCATCCGGGTCT	0.557000													18	47					0	0	1	0	0
KY	339855	broad.mit.edu	37	3	134369698	134369698	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134369698C>T	ENST00000508956.1	-	1	162	c.105G>A	c.(103-105)gcG>gcA	p.A35A	KY_ENST00000503669.1_Silent_p.A35A|KY_ENST00000423778.2_Silent_p.A35A			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	35						cytoskeleton|Z disc	peptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						AGCTCGGGTTCGCCTGCTGGT	0.672000													9	20					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31139024	31139024	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:31139024G>A	ENST00000538351.1	-	7	917	c.163C>T	c.(163-165)Cag>Tag	p.Q55*	ZNF438_ENST00000444692.2_Nonsense_Mutation_p.Q94*|ZNF438_ENST00000375311.1_Intron|ZNF438_ENST00000452305.1_Nonsense_Mutation_p.Q94*|ZNF438_ENST00000442986.1_Nonsense_Mutation_p.Q104*|ZNF438_ENST00000436087.2_Nonsense_Mutation_p.Q104*|ZNF438_ENST00000413025.1_Nonsense_Mutation_p.Q104*|ZNF438_ENST00000361310.3_Nonsense_Mutation_p.Q104*|ZNF438_ENST00000331737.6_Nonsense_Mutation_p.Q94*	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				TGAATTGGCTGAGCTGAGGCA	0.488000													32	127					0	0	1	0	0
HDHD1	8226	broad.mit.edu	37	X	7023738	7023738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:7023738G>A	ENST00000381077.5	-	2	279	c.203C>T	c.(202-204)cCg>cTg	p.P68L	HDHD1_ENST00000498474.2_5'UTR|HDHD1_ENST00000424830.2_Missense_Mutation_p.P91L|HDHD1_ENST00000412827.2_Intron|HDHD1_ENST00000540122.1_Missense_Mutation_p.P68L	NM_001178136.1|NM_012080.4	NP_001171607.1|NP_036212.3	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain containing 1	68					nucleotide metabolic process		metal ion binding|phosphatase activity			breast(2)|large_intestine(1)|lung(3)	6						TTTGGACATCGGGAGCTGCAA	0.502000													4	13					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57437748	57437748	+	Nonsense_Mutation	SNP	G	G	A	rs138607619		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57437748G>A	ENST00000442789.2	-	11	1071	c.784C>T	c.(784-786)Cga>Tga	p.R262*	MYO1A_ENST00000300119.3_Nonsense_Mutation_p.R262*|MYO1A_ENST00000544473.1_Nonsense_Mutation_p.R100*	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	262	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						AGCACTTGTCGAATCTCCTCC	0.517000													29	66					0	0	1	0	0
SAMD3	154075	broad.mit.edu	37	6	130465869	130465869	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:130465869C>T	ENST00000368134.2	-	14	1967	c.1359G>A	c.(1357-1359)agG>agA	p.R453R	SAMD3_ENST00000437477.2_Silent_p.R453R|SAMD3_ENST00000439090.2_Silent_p.R453R|SAMD3_ENST00000457563.2_Silent_p.R477R	NM_001258275.1	NP_001245204.1	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	453										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TGAGCCTCTCCCTTTCTAAAT	0.443000													24	29					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21120147	21120147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21120147C>T	ENST00000377122.4	-	16	2045	c.1649G>A	c.(1648-1650)aGg>aAg	p.R550K	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	550					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TTCAGATGTCCTCTTGGCTCG	0.388000													14	74					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192554	211192554	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:211192554C>T	ENST00000367007.4	-	6	772	c.603G>A	c.(601-603)gaG>gaA	p.E201E	KCNH1_ENST00000271751.4_Silent_p.E201E	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	201					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TCTTTGGTGCCTCTTGCTTGT	0.433000													36	72					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	527691	527691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:527691C>T	ENST00000453061.2	+	12	2762	c.2656C>T	c.(2656-2658)Ctg>Ttg	p.L886L	PIGG_ENST00000504346.1_Silent_p.L797L|PIGG_ENST00000383028.4_Silent_p.L753L|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000310340.5_Silent_p.L878L	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	886					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						AGCCGTGCTCCTGACAGCGTT	0.592000													28	49					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250700	140250700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140250700G>A	ENST00000398640.2	+	1	2012	c.2012G>A	c.(2011-2013)aGc>aAc	p.S671N	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGGTGGAGAGCGGACAGGCG	0.662000													16	68					0	0	1	0	0
DENND5A	23258	broad.mit.edu	37	11	9199886	9199886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:9199886G>A	ENST00000328194.3	-	8	2019	c.1699C>T	c.(1699-1701)Ccc>Tcc	p.P567S	DENND5A_ENST00000530044.1_Missense_Mutation_p.P567S	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	567	dDENN.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGCAGGTAGGGCTCAGGCTGA	0.453000													11	27					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72511377	72511377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72511377C>T	ENST00000373208.1	+	17	2580	c.2580C>T	c.(2578-2580)gcC>gcT	p.A860A	ADAMTS14_ENST00000373207.1_Silent_p.A857A	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	857	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						AGAGCTGGGCCCCCTGCAGCA	0.617000													19	48					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34109088	34109088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34109088C>T	ENST00000389232.4	+	75	10598	c.10528C>T	c.(10528-10530)Cat>Tat	p.H3510Y	RYR3_ENST00000415757.3_Missense_Mutation_p.H3505Y	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3510					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTCTTCCTCCATGGCTATCA	0.463000													7	17					0	0	1	0	0
IL17RE	132014	broad.mit.edu	37	3	9944701	9944701	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9944701C>T	ENST00000454190.2	+	1	170	c.85C>T	c.(85-87)Cgc>Tgc	p.R29C	IL17RE_ENST00000383814.3_Missense_Mutation_p.R29C|IL17RE_ENST00000421412.1_Missense_Mutation_p.R62C|IL17RE_ENST00000295980.3_Missense_Mutation_p.R29C	NM_001193380.1	NP_001180309.1	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E	29						cytoplasm|extracellular region|integral to membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(11)|skin(1)	21				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GATTGGCTTTCGCCACCTGCC	0.612000													36	75					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077764	9077764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9077764G>A	ENST00000397910.4	-	3	9885	c.9682C>T	c.(9682-9684)Cct>Tct	p.P3228S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3229	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTTCCAAGGAGAATTTCTC	0.522000													41	139					0	0	1	0	0
SLC35E3	55508	broad.mit.edu	37	12	69145889	69145889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:69145889C>T	ENST00000398004.2	+	3	863	c.591C>T	c.(589-591)gcC>gcT	p.A197A		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	197						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			TGTCATCTGCCATGTTGCTGG	0.443000													72	179					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49688113	49688113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49688113C>T	ENST00000296452.4	+	4	1701	c.1587C>T	c.(1585-1587)acC>acT	p.T529T		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	529					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GAGAGCCGACCCCCCTGCCGC	0.627000													72	161					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713515	70713515	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70713515G>A	ENST00000530196.1	-	0	1003					NR_003951.1																						TTGTAGCTGGGAACGACTGAT	0.373000													42	89					0	0	1	0	0
OR1J1	347168	broad.mit.edu	37	9	125240122	125240122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125240122G>A	ENST00000259357.2	-	1	113	c.84C>T	c.(82-84)ttC>ttT	p.F28F		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						GGAACAGGGCGAAGAACACGG	0.587000													63	124					0	0	1	0	0
ASS1	445	broad.mit.edu	37	9	133333958	133333958	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133333958C>T	ENST00000372394.1	+	5	826	c.345C>T	c.(343-345)tcC>tcT	p.S115S	ASS1_ENST00000352480.5_Silent_p.S115S|ASS1_ENST00000372393.3_Silent_p.S115S			P00966	ASSY_HUMAN	argininosuccinate synthase 1	115					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	17				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	AGTATGTGTCCCACGGCGCCA	0.647000													6	22					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128643385	128643385	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:128643385C>T	ENST00000368227.3	-	3	660	c.294G>A	c.(292-294)atG>atA	p.M98I	PTPRK_ENST00000368215.3_Missense_Mutation_p.M98I|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368213.5_Missense_Mutation_p.M98I|PTPRK_ENST00000368207.3_Missense_Mutation_p.M98I|PTPRK_ENST00000368226.4_Missense_Mutation_p.M98I|PTPRK_ENST00000525459.1_Missense_Mutation_p.M98I|PTPRK_ENST00000532331.1_Missense_Mutation_p.M98I|PTPRK_ENST00000368210.3_Missense_Mutation_p.M98I			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	98	MAM.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CGTTCTCCTTCATTGTAGGCA	0.388000													75	73					0	0	1	0	0
B4GALT2	8704	broad.mit.edu	37	1	44447081	44447081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44447081C>T	ENST00000434555.2	+	2	377	c.95C>T	c.(94-96)cCa>cTa	p.P32L	B4GALT2_ENST00000372324.1_Silent_p.P83P|B4GALT2_ENST00000356836.6_Silent_p.P83P|B4GALT2_ENST00000309519.7_Silent_p.P112P			O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2	89					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	CTGAGGTCCCCAGTGCCCTGC	0.697000													12	34					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403730	47403730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47403730C>T	ENST00000310638.4	-	2	306	c.275G>A	c.(274-276)gGa>gAa	p.G92E	CYP4A11_ENST00000371904.4_Missense_Mutation_p.G92E|CYP4A11_ENST00000457840.2_5'UTR|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371905.1_Missense_Mutation_p.G92E	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	92					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	AACTTTGCCTCCCCATAGCCA	0.512000													34	107					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43749110	43749110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43749110G>A	ENST00000263801.3	-	12	1933	c.1681C>T	c.(1681-1683)Cct>Tct	p.P561S	TP53BP1_ENST00000382039.3_Missense_Mutation_p.P566S|TP53BP1_ENST00000450115.2_Missense_Mutation_p.P566S|TP53BP1_ENST00000382044.4_Missense_Mutation_p.P566S	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	561					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		TTTTCAGCAGGAACAAATTTA	0.413000								Other conserved DNA damage response genes					8	103					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33412082	33412082	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33412082G>A	ENST00000404816.2	+	6	1714	c.1361G>A	c.(1360-1362)gGg>gAg	p.G454E	LTBP1_ENST00000402934.1_Missense_Mutation_p.G128E|LTBP1_ENST00000354476.3_Missense_Mutation_p.G454E|LTBP1_ENST00000404525.1_Missense_Mutation_p.G128E|LTBP1_ENST00000407925.1_Missense_Mutation_p.G128E|LTBP1_ENST00000390003.4_Missense_Mutation_p.G128E|LTBP1_ENST00000418533.2_Missense_Mutation_p.G128E			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	454					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGGCGTTGGGGACGCATGTC	0.507000													15	52					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155491738	155491738	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155491738A>G	ENST00000302068.4	+	8	1475	c.1412A>G	c.(1411-1413)aAg>aGg	p.K471R	FGB_ENST00000509493.1_Missense_Mutation_p.K252R|FGB_ENST00000502545.1_3'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	471	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	ATGAATTGGAAGGGGTCATGG	0.473000													15	52					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247463	164247463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164247463G>A	ENST00000296533.2	-	2	775	c.244C>T	c.(244-246)Ctt>Ttt	p.L82F	NPY1R_ENST00000509586.1_Intron	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	82					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAGAAGGAAAGGTTCACAATC	0.423000													22	67					0	0	1	0	0
OR2T8	343172	broad.mit.edu	37	1	248084466	248084466	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248084466G>A	ENST00000319968.4	+	1	147	c.147G>A	c.(145-147)tgG>tgA	p.W49*		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	49			W -> R (in dbSNP:rs11204564).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGATTCACTGGGACCACCGGC	0.527000													23	98					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66914658	66914658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66914658C>T	ENST00000586539.1	-	15	2006	c.1818G>A	c.(1816-1818)atG>atA	p.M606I	ABCA8_ENST00000269080.2_Intron|ABCA8_ENST00000430352.2_Missense_Mutation_p.M606I			O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	597	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GAATATTTTTCATTTCCAATT	0.338000													8	5					0	0	1	0	0
NELFE	7936	broad.mit.edu	37	6	31921902	31921902	+	Silent	SNP	G	G	A	rs141063076		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31921902G>A	ENST00000375429.3	-	9	1123	c.897C>T	c.(895-897)ttC>ttT	p.F299F	NELFE_ENST00000375425.5_Silent_p.F306F|NELFE_ENST00000444811.2_Silent_p.F269F	NM_002904.5	NP_002895.3			negative elongation factor complex member E																		CATAGGTGACGAAGGCACAGC	0.527000													11	30					0	0	1	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37962533	37962533	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37962533G>A	ENST00000249014.4	+	2	597	c.177G>A	c.(175-177)ggG>ggA	p.G59G		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	59					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					ATGTCTTCGGGGACACGTCCT	0.652000													8	19					0	0	1	0	0
FATE1	89885	broad.mit.edu	37	X	150891177	150891177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150891177C>T	ENST00000370350.3	+	5	583	c.498C>T	c.(496-498)atC>atT	p.I166I		NM_033085.2	NP_149076.1	Q969F0	FATE1_HUMAN	fetal and adult testis expressed 1	166						endoplasmic reticulum|integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(6)|ovary(1)	15	Acute lymphoblastic leukemia(192;6.56e-05)					CCCTGATCATCGCCGTGCTGG	0.652000													28	19					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69324005	69324005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:69324005C>T	ENST00000260364.5	+	5	720	c.419C>T	c.(418-420)gCc>gTc	p.A140V	NOX5_ENST00000455873.3_Missense_Mutation_p.A123V|NOX5_ENST00000448182.3_Missense_Mutation_p.A112V|NOX5_ENST00000530406.2_Missense_Mutation_p.A130V|NOX5_ENST00000388866.3_Missense_Mutation_p.A158V			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	158	EF-hand 3; atypical; contains an insert of 28 residues.|N-terminal regulatory region; interacts with the C-terminal catalytic region in a calcium-dependent manner.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CGCGAGAGCGCCATCTCGCTG	0.672000													7	27					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56387942	56387942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56387942G>A	ENST00000355701.3	-	20	4500	c.3630C>T	c.(3628-3630)gcC>gcT	p.A1210A	BZRAP1_ENST00000268893.6_Silent_p.A1150A|BZRAP1_ENST00000343736.4_Silent_p.A1210A	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1210						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCGCCTGCTGGGCCCGTGCTC	0.672000													21	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179591878	179591878	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179591878G>A	ENST00000589042.1	-	69	20438	c.20214C>T	c.(20212-20214)ttC>ttT	p.F6738F	TTN_ENST00000342992.6_Silent_p.F5494F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.F6421F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6421	Ig-like 49.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCACAAATGAAATCTCCAC	0.418000													27	99					0	0	1	0	0
ZNF382	84911	broad.mit.edu	37	19	37100898	37100898	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37100898C>T	ENST00000435416.1	+	1	1577	c.82C>T	c.(82-84)Cag>Tag	p.Q28*	ZNF382_ENST00000439428.1_Nonsense_Mutation_p.Q27*|ZNF382_ENST00000423582.1_Intron|ZNF382_ENST00000292928.2_Nonsense_Mutation_p.Q28*			Q96SR6	ZN382_HUMAN	zinc finger protein 382	28	KRAB.|Mediates interaction with TRIM28 (By similarity).|Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGACCCTGCTCAGAAGGCGCT	0.478000													40	82					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107019951	107019951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:107019951G>A	ENST00000369063.3	-	9	1576	c.1111C>T	c.(1111-1113)Cct>Tct	p.P371S	RTN4IP1_ENST00000539449.1_3'UTR|RTN4IP1_ENST00000498091.1_5'UTR	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	371						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		TTAGAAAAAGGAAAGGTTTGT	0.383000													25	46					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144869848	144869848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:144869848C>T	ENST00000367545.3	+	46	6668	c.6668C>T	c.(6667-6669)tCg>tTg	p.S2223L		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2223					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CATCGTACTTCGGAAATTTCA	0.398000													21	31					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49206576	49206576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49206576G>A	ENST00000425340.2	+	2	480	c.363G>A	c.(361-363)agG>agA	p.R121R	FUT2_ENST00000391876.4_Silent_p.R121R	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	121					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		CGGCCAGCAGGATCCCCTGGC	0.657000													28	53					0	0	1	0	0
FAM46C	54855	broad.mit.edu	37	1	118166571	118166571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:118166571C>T	ENST00000369448.3	+	2	1328	c.1081C>T	c.(1081-1083)Cct>Tct	p.P361S		NM_017709.3	NP_060179.2	Q5VWP2	FA46C_HUMAN	family with sequence similarity 46, member C	361										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	15	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CCAGCCGGCCCCTTACGTCAG	0.562000			"""Mis, F, O"""		MM					Multiple Myeloma(3;1.13e-06)			7	40					0	0	1	0	0
KRT84	3890	broad.mit.edu	37	12	52775175	52775175	+	Silent	SNP	C	C	T	rs114877532	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52775175C>T	ENST00000257951.3	-	5	1113	c.1047G>A	c.(1045-1047)cgG>cgA	p.R349R	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	349	Coil 2.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CAGCATCAGCCCGGCTGCGCC	0.577000													38	193					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179417421	179417421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179417421C>T	ENST00000589042.1	-	335	90430	c.90206G>A	c.(90205-90207)aGg>aAg	p.R30069K	TTN_ENST00000342992.6_Missense_Mutation_p.R27501K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R21004K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R21196K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R21129K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R28428K|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28428	Fibronectin type-III 119.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTACCTTTCCTTTCTACAAC	0.448000													24	83					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219521016	219521016	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219521016G>A	ENST00000411696.2	-	3	916	c.137C>T	c.(136-138)tCc>tTc	p.S46F	ZNF142_ENST00000449707.1_Missense_Mutation_p.S46F			P52746	ZN142_HUMAN	zinc finger protein 142	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGGTCCCGGGAAGGACAGGG	0.602000													35	60					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39109233	39109233	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:39109233C>T	ENST00000297668.6	-	15	2362	c.2289G>A	c.(2287-2289)caG>caA	p.Q763Q	CNTNAP3_ENST00000377656.2_Silent_p.Q762Q|CNTNAP3_ENST00000358144.2_Silent_p.Q675Q	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	763	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCATCACAATCTGAGTGACTG	0.463000													17	27					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186672268	186672268	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:186672268G>A	ENST00000343098.5	+	17	18502	c.18502G>A	c.(18502-18504)Gaa>Aaa	p.E6168K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E6079K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TGATGATGATGAAATTATTCA	0.323000													96	92					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74287400	74287400	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74287400G>A	ENST00000262765.5	-	4	3089	c.2910C>T	c.(2908-2910)gcC>gcT	p.A970A		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	970							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						GTCGGTCCGAGGCTCGTGTTC	0.522000													23	42					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38311470	38311470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:38311470C>T	ENST00000553443.1	+	31	5635	c.5635C>T	c.(5635-5637)Ctt>Ttt	p.L1879F	TTC6_ENST00000476979.1_Missense_Mutation_p.L513F|TTC6_ENST00000382320.3_3'UTR|TTC6_ENST00000267368.7_Missense_Mutation_p.L513F					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		AGCACTTGATCTTGAAGACTA	0.363000													39	98					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803167	54803167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54803167G>A	ENST00000391745.1	-	8	877	c.561C>T	c.(559-561)tcC>tcT	p.S187S	LILRA3_ENST00000391744.3_Intron|LILRA3_ENST00000251390.3_Silent_p.S170S					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CATGGGAATGGGAGTTCAGGC	0.567000													55	105					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224609	248224609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248224609C>T	ENST00000359959.3	+	1	626	c.626C>T	c.(625-627)cCc>cTc	p.P209L	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTCGTGTTTCCCTTCATTGCT	0.507000													43	165					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141215075	141215075	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141215075G>A	ENST00000389484.3	-	61	10742	c.9771C>T	c.(9769-9771)gcC>gcT	p.A3257A		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3257					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATCTGTGATGGCATGCCATG	0.403000										TSP Lung(27;0.18)			20	197					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974783	49974783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49974783C>T	ENST00000555099.1	+	1	841	c.809C>T	c.(808-810)gCt>gTt	p.A270V		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						AAAGCAGTTGCTGTATTCTAC	0.378000													26	91					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20448675	20448675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20448675C>T	ENST00000331849.4	+	12	1669	c.1522C>T	c.(1522-1524)Ccc>Tcc	p.P508S		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	508					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CAGCCCAGACCCCATCAGGGG	0.572000													9	46					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716952	13716952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13716952C>T	ENST00000279593.3	-	13	3429	c.3220G>A	c.(3220-3222)Gag>Aag	p.E1074K		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1074					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCATTGCCCTCGATGTTCCCA	0.567000													16	22					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70890626	70890626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70890626C>T	ENST00000264436.3	-	16	2556	c.2112G>A	c.(2110-2112)aaG>aaA	p.K704K	ADD2_ENST00000407644.2_Silent_p.K704K|ADD2_ENST00000355733.3_3'UTR	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	704	Interaction with calmodulin (Potential).				actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						TCTTTTTCTTCTTTGAGGGAG	0.527000													119	233					0	0	1	0	0
ERCC2	2068	broad.mit.edu	37	19	45867734	45867734	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45867734G>A	ENST00000391945.4	-	8	743	c.666C>T	c.(664-666)tcC>tcT	p.S222S	ERCC2_ENST00000391944.3_Silent_p.S144S|ERCC2_ENST00000485403.2_Silent_p.S198S|ERCC2_ENST00000391940.4_Silent_p.S198S|ERCC2_ENST00000221481.6_Intron	NM_000400.3	NP_000391.1	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 2	222	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCAGTTCCTTGGACACCAGGT	0.627000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				7	33					0	0	1	0	0
GPA33	10223	broad.mit.edu	37	1	167032894	167032894	+	Missense_Mutation	SNP	C	C	T	rs145965350		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167032894C>T	ENST00000367868.3	-	4	839	c.496G>A	c.(496-498)Gag>Aag	p.E166K	GPA33_ENST00000527955.1_5'UTR	NM_005814.1	NP_005805.1	Q99795	GPA33_HUMAN	glycoprotein A33 (transmembrane)	166	Ig-like C2-type.					integral to plasma membrane	receptor activity			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						GGTGAGCCCTCCTTTGATTGG	0.562000													33	103					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73044380	73044380	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73044380C>T	ENST00000604411.1	+	0	32341				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GTATTTAAACCCTTGGTTTGT	0.318000													9	6					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204953222	204953222	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204953222G>A	ENST00000367172.4	+	22	2866	c.2538G>A	c.(2536-2538)tgG>tgA	p.W846*	NFASC_ENST00000404076.1_Nonsense_Mutation_p.W825*|NFASC_ENST00000513543.1_Nonsense_Mutation_p.W842*|NFASC_ENST00000367171.4_Nonsense_Mutation_p.W831*|NFASC_ENST00000339876.6_Intron|NFASC_ENST00000539706.1_Nonsense_Mutation_p.W842*|NFASC_ENST00000404907.1_Nonsense_Mutation_p.W842*|NFASC_ENST00000360049.4_Nonsense_Mutation_p.W842*|NFASC_ENST00000367170.4_Nonsense_Mutation_p.W846*|NFASC_ENST00000401399.1_Intron|NFASC_ENST00000367169.4_Intron|NFASC_ENST00000338586.6_Nonsense_Mutation_p.W846*|NFASC_ENST00000338515.6_Nonsense_Mutation_p.W846*			O94856	NFASC_HUMAN	neurofascin	846	Fibronectin type-III 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GCCTTCAGTGGAACCGCGTCT	0.577000													10	53					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117681082	117681082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117681082C>T	ENST00000368508.3	-	23	3736	c.3538G>A	c.(3538-3540)Gca>Aca	p.A1180T	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.A1175T	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1180					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ACTCTTTCTGCTGAAAACGTC	0.403000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								41	52					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129149928	129149928	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:129149928C>T	ENST00000540052.1	+	3	3224	c.3180C>T	c.(3178-3180)ttC>ttT	p.F1060F	BCORL1_ENST00000359304.2_Silent_p.F1060F|BCORL1_ENST00000303743.5_Silent_p.F1060F|BCORL1_ENST00000218147.7_Silent_p.F1060F	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1060					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						ATGTGGTCTTCAATTTAGCCA	0.617000													22	14					0	0	1	0	0
C1orf222	339457	broad.mit.edu	37	1	1920052	1920052	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1920052C>T	ENST00000434971.2	-	4	227	c.195G>A	c.(193-195)aaG>aaA	p.K65K				Q69YW0	CA222_HUMAN	chromosome 1 open reading frame 222	0										breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)	11	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAGCTGTTTTCTTCTTCAATT	0.488000													27	66					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74860079	74860079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:74860079G>A	ENST00000358399.3	+	12	1244	c.1151G>A	c.(1150-1152)gGt>gAt	p.G384D	GDA_ENST00000376989.3_Missense_Mutation_p.G323D|GDA_ENST00000238018.4_Missense_Mutation_p.G384D|GDA_ENST00000545168.1_Missense_Mutation_p.G310D|GDA_ENST00000376986.1_Missense_Mutation_p.G306D	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	384					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GGGCTGGATGGTGAGATTGGA	0.448000													34	133					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42127077	42127077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42127077C>T	ENST00000382448.4	+	2	213	c.204C>T	c.(202-204)tcC>tcT	p.S68S	JMJD7_ENST00000397299.4_Silent_p.S68S|JMJD7-PLA2G4B_ENST00000542534.1_Silent_p.S68S|JMJD7-PLA2G4B_ENST00000342159.4_Silent_p.S68S|JMJD7_ENST00000408047.1_Intron	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		0	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						AGAAGTGGTCCCTCCCCTATT	0.617000													25	72					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416609	29416609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29416609G>A	ENST00000389048.3	-	29	5250	c.4344C>T	c.(4342-4344)tcC>tcT	p.S1448S	ALK_ENST00000431873.1_Silent_p.S278S	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1448					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCTTGCCAGAGGAGGTGGTAG	0.612000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				44	108					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90459638	90459638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90459638G>A	ENST00000405460.2	+	90	18938	c.18842G>A	c.(18841-18843)gGc>gAc	p.G6281D	GPR98_ENST00000425867.2_Missense_Mutation_p.G1942D	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6281					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTGGTCAAGGCAGCCAGGAG	0.488000													4	12					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2808585	2808585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:2808585G>A	ENST00000254695.8	+	3	178	c.88G>A	c.(88-90)Gag>Aag	p.E30K	RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.E30K|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.E11K|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.E30K	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	30					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						CAGGAAGCAGGAGCTGGCCAA	0.592000													15	17					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380251	56380251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56380251G>A	ENST00000526538.1	-	1	727	c.728C>T	c.(727-729)tCc>tTc	p.S243F		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						TGTCAGGTGGGAAGCACACGT	0.448000													43	99					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648052	112648052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112648052G>A	ENST00000471858.1	-	3	668	c.436C>T	c.(436-438)Cac>Tac	p.H146Y	CD200R1_ENST00000490004.1_Missense_Mutation_p.H146Y|CD200R1_ENST00000308611.3_Missense_Mutation_p.H169Y|CD200R1_ENST00000440122.2_Missense_Mutation_p.H169Y|CD200R1_ENST00000295863.4_Missense_Mutation_p.H124Y	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	146	Ig-like C2-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						ACTTGGAGGTGATATCCACGA	0.418000													20	107					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36752667	36752667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36752667G>A	ENST00000354618.5	+	4	1060	c.836G>A	c.(835-837)aGc>aAc	p.S279N	THRAP3_ENST00000469141.2_Missense_Mutation_p.S279N	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	279	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCACTTTCCAGCACATCCCAG	0.612000			T	USP6	aneurysmal bone cysts								44	102					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47295229	47295229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47295229G>A	ENST00000225941.1	+	3	912	c.414G>A	c.(412-414)agG>agA	p.R138R	ABI3_ENST00000419580.2_Silent_p.R132R	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	138					cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			CCTACTGCAGGAGACCCCTCA	0.632000										HNSCC(55;0.14)			25	117					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62299448	62299448	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62299448G>A	ENST00000371158.2	+	17	2217	c.2103G>A	c.(2101-2103)ttG>ttA	p.L701L	INADL_ENST00000316485.6_Silent_p.L701L	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	701	PDZ 5.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TCAGCATTTTGGATTACCAGG	0.378000													25	125					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19471629	19471629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19471629G>A	ENST00000396229.2	+	6	1870	c.1121G>A	c.(1120-1122)aGg>aAg	p.R374K	TMC5_ENST00000542583.2_Missense_Mutation_p.R374K|TMC5_ENST00000564959.1_Missense_Mutation_p.R36K|TMC5_ENST00000561503.1_Missense_Mutation_p.R15K|TMC5_ENST00000219821.5_Missense_Mutation_p.R128K|TMC5_ENST00000541464.1_Missense_Mutation_p.R374K|TMC5_ENST00000381414.4_Missense_Mutation_p.R374K	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	374						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AACCAGCCAAGGACCATGGAA	0.398000													17	40					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19740991	19740991	+	Silent	SNP	G	G	A	rs144936310	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19740991G>A	ENST00000203556.4	-	21	2831	c.2694C>T	c.(2692-2694)acC>acT	p.T898T	GMIP_ENST00000445806.2_Silent_p.T869T|GMIP_ENST00000587238.1_Silent_p.T872T	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	898					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						ATGTGATGGGGGTCTCCTCGC	0.701000													8	25					0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1836644	1836644	+	Silent	SNP	G	G	A	rs144059275	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1836644G>A	ENST00000302787.2	-	5	1100	c.804C>T	c.(802-804)atC>atT	p.I268I		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	268	LETM1.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			CCATCTCCTCGATGGTGTCCT	0.562000													22	69					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55174518	55174518	+	Splice_Site	SNP	C	C	T	rs141935558		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55174518C>T	ENST00000391736.1	+	3	348	c.34_splice	c.e3+1	p.L11_splice	LILRB4_ENST00000270452.2_Splice_Site_p.L11_splice|LILRB4_ENST00000430952.2_Splice_Site_p.L11_splice|LILRB4_ENST00000391733.3_Splice_Site_p.L11_splice|LILRB4_ENST00000391734.3_Splice_Site_p.L11_splice	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	11						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		TGCTCTGCCTCGGTGAGATTT	0.577000											OREG0003670	type=REGULATORY REGION|Gene=LILRB4|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	73					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115815860	115815860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:115815860G>A	ENST00000343348.6	-	12	1995	c.1208C>T	c.(1207-1209)cCc>cTc	p.P403L	CTB-118N6.3_ENST00000510682.1_RNA|SEMA6A_ENST00000510263.1_Missense_Mutation_p.P403L|SEMA6A_ENST00000257414.8_Missense_Mutation_p.P403L|CTB-118N6.3_ENST00000508640.1_RNA|CTB-118N6.3_ENST00000514214.1_RNA	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	403	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GAAGATGGAGGGCACTGCCTC	0.498000													38	79					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122846208	122846208	+	Missense_Mutation	SNP	G	G	A	rs145694364		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122846208G>A	ENST00000264811.5	-	2	1340	c.922C>T	c.(922-924)Cgt>Tgt	p.R308C	TRPC3_ENST00000513531.1_Missense_Mutation_p.R308C|TRPC3_ENST00000379645.3_Missense_Mutation_p.R381C	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	296					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						AGTTTGACACGACTTAATGAA	0.428000													34	161					0	0	1	0	0
P4HTM	54681	broad.mit.edu	37	3	49042403	49042403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49042403C>T	ENST00000343546.4	+	6	1365	c.997C>T	c.(997-999)Cct>Tct	p.P333S	P4HTM_ENST00000383729.4_Missense_Mutation_p.P333S	NM_177938.2	NP_808807.2	Q9NXG6	P4HTM_HUMAN	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	333	Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21					Vitamin C(DB00126)	GGACAGTGGGCCTGTGTACCC	0.612000													25	56					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177034349	177034349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:177034349G>A	ENST00000468418.3	+	3	2597	c.507G>A	c.(505-507)caG>caA	p.Q169Q	HOXD3_ENST00000249440.3_Silent_p.Q169Q|HOXD3_ENST00000410016.1_Silent_p.Q169Q			P31249	HXD3_HUMAN	homeobox D3	169					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGTCTCGACAGAACTCCAAGC	0.572000													52	111					0	0	1	0	0
PSKH2	85481	broad.mit.edu	37	8	87076389	87076389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87076389C>T	ENST00000276616.2	-	2	731	c.657G>A	c.(655-657)atG>atA	p.M219I	PSKH2_ENST00000517981.1_5'UTR	NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	219	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			AGAGTGTCTTCATTGTCCAGT	0.438000													7	77					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141260537	141260537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141260537C>T	ENST00000389484.3	-	54	9628	c.8657G>A	c.(8656-8658)aGt>aAt	p.S2886N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2886					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTACCTGCACTTTTACACTT	0.368000										TSP Lung(27;0.18)			19	80					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115399878	115399878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115399878C>T	ENST00000369522.3	+	4	459	c.219C>T	c.(217-219)ttC>ttT	p.F73F	SYCP1_ENST00000369518.1_Silent_p.F73F	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	73	Asp/Glu-rich (acidic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGTTAATTTCTTGCCCGTGC	0.313000													10	43					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77607174	77607174	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:77607174G>A	ENST00000461745.1	+	9	2211	c.1311G>A	c.(1309-1311)ctG>ctA	p.L437L	ROBO2_ENST00000487694.3_Silent_p.L453L|ROBO2_ENST00000332191.8_Silent_p.L437L	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	437	Ig-like C2-type 5.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAGCGTTACTGAAATGTAAAG	0.438000													39	77					0	0	1	0	0
LRRC19	64922	broad.mit.edu	37	9	26999654	26999654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:26999654G>A	ENST00000380055.5	-	2	149	c.39C>T	c.(37-39)ctC>ctT	p.L13L	IFT74_ENST00000429045.2_Intron|IFT74_ENST00000433700.1_Intron|IFT74_ENST00000380062.5_Intron|IFT74_ENST00000443698.1_Intron	NM_022901.2	NP_075052.1	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19	13						integral to membrane				breast(1)|endometrium(2)|kidney(1)|lung(2)	6		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)		ATATCATGGAGAGGGGCCAAA	0.303000													20	27					0	0	1	0	0
GBAS	2631	broad.mit.edu	37	7	56065061	56065061	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:56065061T>G	ENST00000322090.3	+	9	744	c.715T>G	c.(715-717)Tac>Gac	p.Y239D	GBAS_ENST00000446778.1_Missense_Mutation_p.Y200D	NM_001483.2	NP_001474.1	O75323	NIPS2_HUMAN	glioblastoma amplified sequence	239						integral to plasma membrane|membrane fraction|mitochondrion	protein binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(2)	5	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTTTTAAGCTTACAGGGATCT	0.418000													32	83					0	0	1	0	0
RIPPLY3	53820	broad.mit.edu	37	21	38380522	38380522	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38380522C>T	ENST00000329553.2	+	2	380	c.171_splice	c.e2+1	p.P57_splice	RIPPLY3_ENST00000485272.1_3'UTR	NM_018962.2	NP_061835.1			ripply transcriptional repressor 3																		ACTGGAAGGCCGGTAAGGTTC	0.597000													17	37					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55961752	55961752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55961752G>A	ENST00000263923.4	-	20	3104	c.2809C>T	c.(2809-2811)Ccc>Tcc	p.P937S		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	937	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ACCTTGTAGGGGACAAATTCA	0.423000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			22	59					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815176	106815176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106815176G>A	ENST00000407775.2	+	8	3116	c.2866G>A	c.(2866-2868)Gaa>Aaa	p.E956K	ZFPM2_ENST00000520492.1_Missense_Mutation_p.E824K|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.E687K|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.E824K|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	956					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TGCTACAAAAGAAGAAAACAG	0.443000													5	21					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82579556	82579556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82579556C>T	ENST00000423517.2	-	6	10685	c.10348G>A	c.(10348-10350)Gaa>Aaa	p.E3450K	PCLO_ENST00000333891.8_Missense_Mutation_p.E3450K|PCLO_ENST00000437081.1_Missense_Mutation_p.E170K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3381					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTGGCATCTTCGTCATCCGTT	0.438000													30	68					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80655837	80655837	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80655837C>T	ENST00000458043.2	+	18	1957	c.1951C>T	c.(1951-1953)Cca>Tca	p.P651S	OTOGL_ENST00000547103.1_Missense_Mutation_p.P651S	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TGTTCATGTCCCAGTGGTGGA	0.403000													47	62					0	0	1	0	0
PRMT1	3276	broad.mit.edu	37	19	50188094	50188094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50188094C>T	ENST00000532489.1	+	7	1007	c.501C>T	c.(499-501)atC>atT	p.I167I	PRMT1_ENST00000391851.4_Silent_p.I195I|PRMT1_ENST00000454376.2_Silent_p.I213I			Q8WUW5	Q8WUW5_HUMAN	protein arginine methyltransferase 1	194						cytoplasm	protein methyltransferase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(2)	12		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00103)|GBM - Glioblastoma multiforme(134;0.012)		ACTACAAGATCCACTGTGAGC	0.692000											OREG0025627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	17					0	0	1	0	0
HAS3	3038	broad.mit.edu	37	16	69143776	69143776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:69143776G>A	ENST00000306560.1	+	2	634	c.478G>A	c.(478-480)Gag>Aag	p.E160K	HAS3_ENST00000219322.3_Missense_Mutation_p.E160K|HAS3_ENST00000569188.1_Missense_Mutation_p.E160K	NM_005329.2	NP_005320.2	O00219	HAS3_HUMAN	hyaluronan synthase 3	160					carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|urinary_tract(2)	16		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		TGAGGCAGGCGAGGGTGAGAC	0.647000													13	60					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68984806	68984806	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68984806G>A	ENST00000288368.4	+	14	1846		c.e14+1		PREX2_ENST00000529398.1_Splice_Site	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2						G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AATTGCACAGGTAAATAGACA	0.348000													11	114					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53342917	53342917	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:53342917C>T	ENST00000226067.5	+	1	545	c.72C>T	c.(70-72)tcC>tcT	p.S24S		NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	24					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						TGCTCAGGTCCCTGCTGGAGA	0.642000			T	TCF3	ALL								4	30					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14367010	14367010	+	Silent	SNP	C	C	T	rs141984882		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14367010C>T	ENST00000344204.4	+	16	2820	c.2796C>T	c.(2794-2796)gcC>gcT	p.A932A	TRIO_ENST00000537187.1_Silent_p.A932A|TRIO_ENST00000509967.2_Silent_p.A883A	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	932					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TGTTAAATGCCGGACTTATCA	0.552000													17	92					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234442224	234442224	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234442224G>A	ENST00000251722.6	-	11	1486	c.1369C>T	c.(1369-1371)Cag>Tag	p.Q457*	USP40_ENST00000450966.1_Nonsense_Mutation_p.Q469*|USP40_ENST00000427112.2_Nonsense_Mutation_p.Q457*			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	457					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CTGATTGGCTGGACTTTAGAA	0.423000													31	74					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54617532	54617532	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:54617532G>A	ENST00000302287.3	+	4	709	c.303G>A	c.(301-303)gtG>gtA	p.V101V	VSTM2A_ENST00000402613.3_Silent_p.V101V|VSTM2A_ENST00000498834.1_3'UTR|VSTM2A_ENST00000402026.2_Silent_p.V100V|VSTM2A_ENST00000404951.1_Silent_p.V101V|VSTM2A_ENST00000407838.3_Silent_p.V101V			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	101	Ig-like V-type.					extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			TTCAGACAGTGAAAGTCCAAG	0.378000													7	22					0	0	1	0	0
GRIN3B	116444	broad.mit.edu	37	19	1005273	1005273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1005273C>T	ENST00000234389.3	+	3	1792	c.1773C>T	c.(1771-1773)ttC>ttT	p.F591F	GRIN3B_ENST00000588335.1_3'UTR	NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	591					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity			breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCGCGCTCTTCCTCACCGTGT	0.667000													22	72					0	0	1	0	0
GGN	199720	broad.mit.edu	37	19	38877095	38877095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38877095C>T	ENST00000334928.6	-	3	939	c.807G>A	c.(805-807)ggG>ggA	p.G269G	AC005789.9_ENST00000585411.1_RNA|GGN_ENST00000591809.1_Intron	NM_152657.3	NP_689870.3	Q86UU5	GGN_HUMAN	gametogenetin	269	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTCCGCCGCCCCCCAGCGAAG	0.652000													17	44					0	0	1	0	0
PNPLA8	50640	broad.mit.edu	37	7	108119732	108119732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:108119732G>A	ENST00000426128.2	-	9	1909	c.1784C>T	c.(1783-1785)tCc>tTc	p.S595F	PNPLA8_ENST00000257694.8_Missense_Mutation_p.S657F|PNPLA8_ENST00000388728.5_Missense_Mutation_p.S595F|PNPLA8_ENST00000422087.1_Missense_Mutation_p.S657F|PNPLA8_ENST00000436062.1_Missense_Mutation_p.S657F|PNPLA8_ENST00000453144.1_Missense_Mutation_p.S557F	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	657	Patatin.				fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						AGTGCCCAGGGATACTATGCA	0.418000													40	117					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151945118	151945118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151945118G>A	ENST00000355193.2	-	14	2619	c.2401C>T	c.(2401-2403)Cct>Tct	p.P801S	KMT2C_ENST00000262189.6_Missense_Mutation_p.P801S					lysine (K)-specific methyltransferase 2C																		AGAGCTGAAGGGTAATTATGC	0.433000													47	883					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	124097411	124097411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:124097411C>T	ENST00000422452.2	-	1	255	c.192G>A	c.(190-192)agG>agA	p.R64R	TENM1_ENST00000371130.3_Silent_p.R64R	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CTACTTCTTTCCTCTTTCTAC	0.358000													23	119					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72367986	72367986	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72367986C>T	ENST00000335666.4	+	4	684	c.636C>T	c.(634-636)ttC>ttT	p.F212F		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	212						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						TCATCGTGTTCGCGGGCTTCC	0.652000													14	20					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5545195	5545195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5545195G>A	ENST00000382368.3	-	2	208	c.85C>T	c.(85-87)Cta>Tta	p.L29L	FBXL18_ENST00000453700.3_Silent_p.L29L	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	29	F-box.								FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GAGAACCCTAGGAGGTGGACC	0.552000													29	59					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802134	185802134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185802134G>A	ENST00000302277.6	+	4	2605	c.2011G>A	c.(2011-2013)Gaa>Aaa	p.E671K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	671						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAGTGACAATGAAGAAATGTG	0.313000													28	94					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87195420	87195420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87195420G>A	ENST00000265724.3	-	8	1085	c.668C>T	c.(667-669)cCt>cTt	p.P223L	ABCB1_ENST00000543898.1_Missense_Mutation_p.P159L	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	223	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCCAAGAACAGGACTGATGGC	0.463000													22	57					0	0	1	0	0
ZBTB34	403341	broad.mit.edu	37	9	129642196	129642196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:129642196C>T	ENST00000319119.4	+	2	603	c.518C>T	c.(517-519)tCt>tTt	p.S173F	ZBTB34_ENST00000373452.2_Missense_Mutation_p.S169F	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						CCATATTGCTCTCAGGGACGG	0.587000													38	57					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68950492	68950492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68950492C>T	ENST00000288368.4	+	7	1081	c.804C>T	c.(802-804)ttC>ttT	p.F268F	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	268	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.F268F(2)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TTTTTCTTTTCGATAATCTTT	0.413000													24	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074867	9074867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9074867G>A	ENST00000397910.4	-	3	12782	c.12579C>T	c.(12577-12579)ttC>ttT	p.F4193F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4195	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCAGACAAGAAAACTGAGG	0.507000													20	59					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166418738	166418738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:166418738G>A	ENST00000402744.4	+	9	1687	c.1407G>A	c.(1405-1407)atG>atA	p.M469I		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	469					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTGGAAAATGATGTCAGAAA	0.289000													24	56					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142481378	142481378	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142481378G>A	ENST00000603901.1	+	0	452					NR_001296.3																						CTGAGCTCTGGGGGTGAGTGG	0.547000													4	22					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150773146	150773146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150773146G>A	ENST00000370357.4	+	3	302	c.57G>A	c.(55-57)agG>agA	p.R19R		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	19						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCTCAAAGGAAATTAAACT	0.333000													15	8					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48796017	48796017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48796017C>T	ENST00000316623.5	-	17	2535	c.2080G>A	c.(2080-2082)Gaa>Aaa	p.E694K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	694	TB 3.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGGCAAGGTTCCCCAAATGCA	0.493000													28	71					0	0	1	0	0
METTL17	64745	broad.mit.edu	37	14	21464991	21464991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21464991C>T	ENST00000339374.6	+	14	1546	c.1313C>T	c.(1312-1314)cCt>cTt	p.P438L	METTL17_ENST00000556670.2_Missense_Mutation_p.P429L|METTL17_ENST00000382985.4_Silent_p.T462T|RP11-84C10.4_ENST00000557335.1_RNA	NM_001029991.1|NM_022734.2	NP_001025162.1|NP_073571.1	Q9H7H0	MET17_HUMAN	methyltransferase like 17	438					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20						GATCTTTTACCTGTGCTTACT	0.522000													39	94					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95683710	95683710	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95683710C>T	ENST00000433389.2	+	11	1453	c.1263C>T	c.(1261-1263)ctC>ctT	p.L421L	ESRP1_ENST00000358397.5_Silent_p.L421L|ESRP1_ENST00000454170.2_Silent_p.L421L|ESRP1_ENST00000423620.2_Silent_p.L421L	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	421					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						CGGCCCCTCTCATTCCACTTC	0.483000													16	82					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46067533	46067533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46067533C>T	ENST00000295452.4	-	4	557	c.390G>A	c.(388-390)atG>atA	p.M130I		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	130					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TAAGCACTTTCATGGTACTAT	0.313000													16	44					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37146532	37146532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:37146532C>T	ENST00000262879.6	+	9	1590	c.1306C>T	c.(1306-1308)Cgg>Tgg	p.R436W	RALGAPB_ENST00000397040.1_Missense_Mutation_p.R436W|RALGAPB_ENST00000397042.3_Missense_Mutation_p.R436W|RALGAPB_ENST00000537204.1_Missense_Mutation_p.R436W|RALGAPB_ENST00000397038.1_Missense_Mutation_p.R214W			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	436					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity	p.R436R(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						GCCTGCCCCTCGGAGACCAAA	0.468000													41	75					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6128444	6128444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6128444G>A	ENST00000261405.5	-	28	4394	c.4140C>T	c.(4138-4140)atC>atT	p.I1380I		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1380	VWFA 1; binding site for platelet glycoprotein Ib.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GGAGCAGGGTGATGCGGGAGG	0.582000													15	62					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56233261	56233261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56233261G>A	ENST00000268912.5	+	1	768	c.747G>A	c.(745-747)atG>atA	p.M249I		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M249I(1)		kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TGGTGTCCATGATCTTCATTC	0.522000													11	78					0	0	1	0	0
TUBA1A	7846	broad.mit.edu	37	12	49579395	49579395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49579395G>A	ENST00000301071.7	-	4	1098	c.754C>T	c.(754-756)Ctg>Ttg	p.L252L	TUBA1A_ENST00000550767.1_Silent_p.L217L|TUBA1A_ENST00000295766.5_Silent_p.L252L	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	252					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						AATTCTGTCAGGTCAACATTC	0.488000													27	72					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62676119	62676119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62676119C>T	ENST00000498273.1	+	4	1968	c.1673C>T	c.(1672-1674)cCc>cTc	p.P558L		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	558										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						TTGGCCTCTCCCTCAAAGTCA	0.438000													29	70					0	0	1	0	0
HOXC8	3224	broad.mit.edu	37	12	54405148	54405148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54405148G>A	ENST00000040584.4	+	2	949	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_022658.3	NP_073149.1	P31273	HXC8_HUMAN	homeobox C8	238						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	8						ggaggaaaaggaagaAAACAA	0.448000													20	57					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69409628	69409628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69409628C>T	ENST00000303714.4	+	16	1511	c.1189C>T	c.(1189-1191)Cgt>Tgt	p.R397C		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	397					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						ATTTTAGGTTCGTTGGGGAGA	0.413000									Familial Infantile Hemangioma				14	37					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142633	48142633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48142633G>A	ENST00000405493.2	-	11	1206	c.997C>T	c.(997-999)Cct>Tct	p.P333S	RAPGEF3_ENST00000549151.1_Missense_Mutation_p.P333S|RAPGEF3_ENST00000548919.1_Missense_Mutation_p.P333S|RAPGEF3_ENST00000389212.3_Missense_Mutation_p.P375S|RAPGEF3_ENST00000171000.4_Missense_Mutation_p.P333S|RAPGEF3_ENST00000395358.3_Missense_Mutation_p.P375S|RAPGEF3_ENST00000449771.2_Missense_Mutation_p.P375S	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	333					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GGTCGGGAAGGGCCGGCGCCC	0.597000													41	107					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9086521	9086521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9086521C>T	ENST00000397910.4	-	1	5497	c.5294G>A	c.(5293-5295)gGc>gAc	p.G1765D		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1765	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAATGTGCTGCCCCCTATGAA	0.502000													6	73					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50295006	50295006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50295006C>T	ENST00000320634.3	-	2	212	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K	FAIM2_ENST00000550890.1_5'UTR	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	40					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						GAGGTGGCTTCCTCATAGGAG	0.667000													12	45					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119031618	119031618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119031618G>A	ENST00000307417.3	+	15	2107	c.1743G>A	c.(1741-1743)acG>acA	p.T581T	ABCG4_ENST00000449422.2_Silent_p.T581T|ABCG4_ENST00000531739.1_Silent_p.T581T	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	581	ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity	p.T581T(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGATCCTGACGATCTATGGCA	0.572000													14	29					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96789678	96789678	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96789678C>T	ENST00000342380.2	-	9	1206	c.1207G>A	c.(1207-1209)Gga>Aga	p.G403R		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	403					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						GGCTGGATTCCTGCTTCTGAA	0.592000													30	67					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688703	26688703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26688703C>T	ENST00000529632.2	+	2	622	c.426C>T	c.(424-426)gtC>gtT	p.V142V	SEZ6L_ENST00000343706.4_Silent_p.V142V|SEZ6L_ENST00000360929.3_Silent_p.V142V|SEZ6L_ENST00000404234.3_Silent_p.V142V|SEZ6L_ENST00000248933.6_Silent_p.V142V|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000403121.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	142						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CAGCCACTGTCCAAAGGGCAG	0.662000													12	35					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165984197	165984197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165984197C>T	ENST00000360093.3	-	18	3828	c.3337G>A	c.(3337-3339)Gaa>Aaa	p.E1113K	SCN3A_ENST00000409101.3_Missense_Mutation_p.E1064K|SCN3A_ENST00000283254.7_Missense_Mutation_p.E1113K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1113						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TTTAAGTTTTCAAAGTCAGAC	0.358000													38	78					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107734	55107734	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55107734C>T	ENST00000251372.3	+	7	1221	c.1039C>T	c.(1039-1041)Cag>Tag	p.Q347*	LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	347	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		CCTGCTGTGTCAGTCATGGGG	0.592000													27	86					0	0	1	0	0
PARP16	54956	broad.mit.edu	37	15	65559098	65559098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65559098C>T	ENST00000261888.6	-	3	766	c.321G>A	c.(319-321)aaG>aaA	p.K107K	PARP16_ENST00000444347.2_Intron|PARP16_ENST00000558873.1_5'UTR	NM_017851.4	NP_060321.3	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	107	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						GCTTTTGGATCTTTTCAAACT	0.438000													6	34					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67066438	67066438	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:67066438G>T	ENST00000315962.4	+	9	1766	c.1393G>T	c.(1393-1395)Ggt>Tgt	p.G465C	TRIM55_ENST00000350034.4_Intron|TRIM55_ENST00000276573.7_Missense_Mutation_p.G465C|TRIM55_ENST00000353317.5_Intron	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	465						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			AGGGAGCGAAGGTCTGGGGCA	0.567000													7	67					8.12818e-05	8.14103e-05	1	1	0
ADCY10	55811	broad.mit.edu	37	1	167865839	167865839	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167865839G>T	ENST00000367848.1	-	7	954	c.457C>A	c.(457-459)Cac>Aac	p.H153N	ADCY10_ENST00000545172.1_Missense_Mutation_p.H92N|ADCY10_ENST00000367851.4_Missense_Mutation_p.H245N			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	245	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTACTTTTGTGCTCACCAGAA	0.398000													99	235					3.69185e-53	3.7189e-53	1	1	0
PGBD1	84547	broad.mit.edu	37	6	28269783	28269783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28269783G>A	ENST00000405948.2	+	7	2572	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	PGBD1_ENST00000259883.3_Missense_Mutation_p.E718K	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	718					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						TGCTGATAACGAAGAAATCCC	0.403000													21	118					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100144721	100144721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:100144721C>T	ENST00000370575.4	-	15	1706	c.1658G>A	c.(1657-1659)gGa>gAa	p.G553E	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	553							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						AGCCCCACTTCCACAGAGATA	0.612000													8	20					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164781252	164781252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:164781252G>A	ENST00000420696.2	+	6	1051	c.863G>A	c.(862-864)cGa>cAa	p.R288Q	PBX1_ENST00000401534.1_Missense_Mutation_p.R288Q|PBX1_ENST00000540246.1_Missense_Mutation_p.R183Q|PBX1_ENST00000560641.1_Missense_Mutation_p.R183Q|PBX1_ENST00000540236.1_Missense_Mutation_p.R288Q|PBX1_ENST00000559240.1_Intron|PBX1_ENST00000367897.1_Missense_Mutation_p.R288Q	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	288					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						GGAAATAAGCGAATCCGGTAC	0.388000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								21	53					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126062903	126062903	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:126062903T>C	ENST00000318410.7	-	18	2451	c.2102A>G	c.(2101-2103)gAt>gGt	p.D701G	KIAA0196_ENST00000517845.1_Missense_Mutation_p.D553G	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	701					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTGCTTTGGATCCACCTAAGT	0.448000													15	67					0	0	1	0	0
C15orf43	145645	broad.mit.edu	37	15	45248981	45248981	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45248981G>A	ENST00000340827.3	+	1	81		c.e1+1			NM_152448.2	NP_689661.1	Q8NHR7	CO043_HUMAN	chromosome 15 open reading frame 43											NS(1)|breast(2)|large_intestine(1)|lung(2)|skin(2)	8		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		CAATTCTGGGGTAGGAAGCTG	0.582000													23	61					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3180142	3180142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3180142C>T	ENST00000355072.5	+	35	4726	c.4581C>T	c.(4579-4581)atC>atT	p.I1527I		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1527					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTGATGGCATCATGGCCAGTG	0.418000													31	124					0	0	1	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767608	143767608	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:143767608C>A	ENST00000419275.1	-	1	273	c.241G>T	c.(241-243)Gag>Tag	p.E81*		NM_001123068.1	NP_001116540.1	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like 4G	81	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(2)|kidney(1)|lung(8)|ovary(1)|skin(1)	14						TCAAATTTCTCCCCATAGATG	0.453000													63	245					3.58576e-35	3.61153e-35	1	1	0
SHE	126669	broad.mit.edu	37	1	154461646	154461646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154461646C>T	ENST00000304760.2	-	3	991	c.905G>A	c.(904-906)aGg>aAg	p.R302K		NM_001010846.2	NP_001010846.1	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	302										breast(4)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	14	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCCCTCTGCCCTGGGCCCCCC	0.647000													23	55					0	0	1	0	0
ATP5A1	498	broad.mit.edu	37	18	43678154	43678154	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43678154G>A	ENST00000282050.2	-	2	188	c.44C>T	c.(43-45)cCt>cTt	p.P15L	ATP5A1_ENST00000591267.1_5'UTR|ATP5A1_ENST00000590665.1_Missense_Mutation_p.P15L|ATP5A1_ENST00000398752.6_Missense_Mutation_p.P15L|ATP5A1_ENST00000593152.2_5'UTR	NM_001001937.1	NP_001001937.1	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	15					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						GGCCCGCCGAGGAAGGGCGCG	0.711000													11	31					0	0	1	0	0
CERS6	253782	broad.mit.edu	37	2	169487532	169487532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169487532G>A	ENST00000305747.6	+	4	1032	c.445G>A	c.(445-447)Gga>Aga	p.G149R	CERS6_ENST00000392687.4_Missense_Mutation_p.G149R	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	149	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity	p.G149*(1)									ATTTACCTACGGAGTCAGATT	0.299000													21	92					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20994161	20994161	+	Missense_Mutation	SNP	G	G	A	rs145048646		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20994161G>A	ENST00000261383.3	-	49	7740	c.7741C>T	c.(7741-7743)Cct>Tct	p.P2581S	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2581	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATCAGCGAAGGGAACATCCGC	0.488000													36	79					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	39087296	39087296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39087296C>T	ENST00000400482.3	-	3	753	c.164G>A	c.(163-165)aGg>aAg	p.R55K	KCNJ6_ENST00000288309.6_Missense_Mutation_p.R55K	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	55					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CCTCACGTACCTCTGGATTTT	0.522000													35	121					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440502	40440502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40440502G>A	ENST00000319592.4	-	4	1118	c.409C>T	c.(409-411)Cgc>Tgc	p.R137C	RBM47_ENST00000381793.2_Missense_Mutation_p.R137C|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381795.6_Missense_Mutation_p.R137C|RBM47_ENST00000514014.1_Missense_Mutation_p.R99C|RBM47_ENST00000295971.7_Missense_Mutation_p.R137C			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	137	RRM 1.					nucleus	nucleotide binding|RNA binding	p.R137C(3)		breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CGGCCCGGGCGGATCTCGTAG	0.622000													26	42					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826190	43826190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43826190C>T	ENST00000389420.3	-	21	3012	c.3013G>A	c.(3013-3015)Gaa>Aaa	p.E1005K	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.E159K|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E1005K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1005	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCTTGGCATTCATTGTCAGCA	0.428000													39	53					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100266060	100266060	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100266060C>T	ENST00000515683.1	-	0	877				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	GTCGAAAATCCACAGCCAATG	0.507000													43	117					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123966241	123966241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:123966241C>T	ENST00000314393.4	+	3	3326	c.2491C>T	c.(2491-2493)Cct>Tct	p.P831S		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	831						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CGACTGCGTCCCTGCAGAGGC	0.567000													6	25					0	0	1	0	0
MYEOV2	150678	broad.mit.edu	37	2	241069402	241069402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241069402G>A	ENST00000307266.3	-	4	306	c.307C>T	c.(307-309)Ccc>Tcc	p.P103S		NM_138336.1	NP_612209.1	Q8WXC6	MYOV2_HUMAN	myeloma overexpressed 2	0										breast(1)|lung(5)|pancreas(1)	7		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		TGCAGTGCGGGAACCATGGAG	0.602000													20	47					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21641177	21641177	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21641177A>T	ENST00000328843.6	+	18	3620	c.3589A>T	c.(3589-3591)Atc>Ttc	p.I1197F	DNAH11_ENST00000409508.3_Missense_Mutation_p.I1197F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1197	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AAAAGAAACGATCACCCTCTT	0.418000									Kartagener syndrome				9	19					0	0	1	0	0
ELAVL3	1995	broad.mit.edu	37	19	11568980	11568980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11568980C>T	ENST00000359227.3	-	5	1033	c.609G>A	c.(607-609)gcG>gcA	p.A203A	ELAVL3_ENST00000438662.2_Silent_p.A203A	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	203	RRM 2.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding	p.A203A(1)		breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						TTGGGTTGTTCGCGAACTTGA	0.602000													29	64					0	0	1	0	0
TRH	7200	broad.mit.edu	37	3	129694861	129694861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129694861G>A	ENST00000302649.3	+	2	729	c.202G>A	c.(202-204)Gag>Aag	p.E68K	TRH_ENST00000507066.1_Intron	NM_007117.3	NP_009048.1	P20396	TRH_HUMAN	thyrotropin-releasing hormone	68					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)	14						GGACCAGGGTGAGCACTCCGG	0.667000													13	24					0	0	1	0	0
BEND6	221336	broad.mit.edu	37	6	56857310	56857310	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56857310G>A	ENST00000370748.3	+	3	690	c.255G>A	c.(253-255)cgG>cgA	p.R85R	BEND6_ENST00000370745.1_Silent_p.R85R|BEND6_ENST00000370750.2_Silent_p.R85R|BEND6_ENST00000370746.3_Silent_p.R85R			Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	85										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						CAAACACCCGGAAAGAAAACA	0.383000													32	190					0	0	1	0	0
SPINK7	84651	broad.mit.edu	37	5	147693756	147693756	+	Missense_Mutation	SNP	G	G	A	rs138587974		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147693756G>A	ENST00000274565.4	+	3	242	c.181G>A	c.(181-183)Ggg>Agg	p.G61R	SPINK7_ENST00000523535.1_Missense_Mutation_p.G35R|SPINK7_ENST00000514394.1_3'UTR|RP11-373N22.3_ENST00000501695.3_RNA	NM_032566.2	NP_115955.1	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7 (putative)	61	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCACCTATGGGAATGAATG	0.468000													17	123					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71887770	71887770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71887770C>T	ENST00000258104.3	+	44	5152	c.4875C>T	c.(4873-4875)ccC>ccT	p.P1625P	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Silent_p.P1626P|DYSF_ENST00000409744.1_Silent_p.P1633P|DYSF_ENST00000410020.3_Silent_p.P1664P|DYSF_ENST00000413539.2_Silent_p.P1656P|DYSF_ENST00000429174.2_Silent_p.P1646P|DYSF_ENST00000409366.1_Silent_p.P1647P|DYSF_ENST00000409582.3_Silent_p.P1663P|DYSF_ENST00000409762.1_Silent_p.P1642P|DYSF_ENST00000409651.1_Silent_p.P1657P|DYSF_ENST00000410041.1_Silent_p.P1643P	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1625	C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CGCTGGAGCCCGTATTTGGAA	0.507000													16	37					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125555795	125555795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125555795G>A	ENST00000431078.1	+	19	3476	c.3112G>A	c.(3112-3114)Gaa>Aaa	p.E1038K		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1038	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCCATCCAAGGAAAACATTGC	0.438000													20	35					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41482155	41482155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41482155C>T	ENST00000314992.5	-	9	1052	c.862G>A	c.(862-864)Gac>Aac	p.D288N	EXD1_ENST00000458580.2_Missense_Mutation_p.D346N	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	288					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						CCAAGCCGGTCTGCAGACCCT	0.527000													26	69					0	0	1	0	0
MR1	3140	broad.mit.edu	37	1	181021631	181021631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181021631C>T	ENST00000367580.5	+	4	870	c.865C>T	c.(865-867)Ctt>Ttt	p.L289F	MR1_ENST00000282990.6_Intron|MR1_ENST00000438435.2_Intron|MR1_ENST00000434571.2_Intron|MR1_ENST00000367579.3_Missense_Mutation_p.L244F	NM_001531.2	NP_001522.1	Q95460	HMR1_HUMAN	major histocompatibility complex, class I-related	289	Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	18						CCACATGGTTCTTCAGGTCCC	0.582000													19	37					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183197559	183197559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183197559G>A	ENST00000264144.4	+	11	1584	c.1519G>A	c.(1519-1521)Gaa>Aaa	p.E507K	LAMC2_ENST00000493293.1_Missense_Mutation_p.E507K	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	507	Laminin EGF-like 6.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						CCCCTTTGGTGAACATGGCCC	0.557000											OREG0014041	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	68					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55925701	55925701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55925701C>T	ENST00000244728.5	-	26	2737	c.2340G>A	c.(2338-2340)ttG>ttA	p.L780L	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Silent_p.L180L|COL21A1_ENST00000535941.1_Silent_p.L780L|COL21A1_ENST00000370819.1_Silent_p.L777L	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	780	Collagen-like 5.			L -> W (in Ref. 7; AAH45597).	cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GCTTCCCATCCAAACCTGGGG	0.478000													26	31					0	0	1	0	0
ZNF280D	54816	broad.mit.edu	37	15	56961140	56961140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:56961140G>A	ENST00000559237.1	-	13	2070	c.1387C>T	c.(1387-1389)Cgt>Tgt	p.R463C	ZNF280D_ENST00000396245.1_Missense_Mutation_p.R180C|ZNF280D_ENST00000559000.1_Missense_Mutation_p.R463C|ZNF280D_ENST00000267807.7_Missense_Mutation_p.R476C	NM_001002843.1	NP_001002843.1	Q6N043	Z280D_HUMAN	zinc finger protein 280D	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(4)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	30				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		TTTGTACAACGATGTATTCCT	0.328000													17	66					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187024	123187024	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123187024G>A	ENST00000328880.5	-	1	866	c.807C>T	c.(805-807)taC>taT	p.Y269Y	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	269					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	CCACCGAGCGGTACACTTCAC	0.552000													7	43					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55569675	55569675	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55569675G>A	ENST00000294383.6	-	42	4898	c.4899C>T	c.(4897-4899)agC>agT	p.S1633S	USP24_ENST00000407756.1_Silent_p.S1473S	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1633					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CTGCCAATCGGCTATTCGCTG	0.348000													7	6					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817311	4817311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4817311G>A	ENST00000248244.5	-	2	1308	c.1079C>T	c.(1078-1080)cCt>cTt	p.P360L		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	360	Pro-rich.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		aggaggaggaggGGATGTTTC	0.542000													21	71					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44013158	44013158	+	Missense_Mutation	SNP	C	C	T	rs144036424		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44013158C>T	ENST00000269439.7	+	2	118	c.67C>T	c.(67-69)Ccc>Tcc	p.P23S	RNF165_ENST00000543885.1_Intron	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	23							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		TCCAGGTGCCCCCTTTCAAAG	0.677000													13	22					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115350393	115350393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115350393C>T	ENST00000369358.4	-	40	5168	c.4924G>A	c.(4924-4926)Gac>Aac	p.D1642N	NRAP_ENST00000360478.3_Missense_Mutation_p.D1599N|NRAP_ENST00000369360.3_Missense_Mutation_p.D1607N|NRAP_ENST00000359988.3_Missense_Mutation_p.D1634N			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1634						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TGCTCCGGGTCGCAGGTGGGC	0.667000													15	52					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34025289	34025289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34025289G>A	ENST00000374372.1	-	3	923	c.420C>T	c.(418-420)gtC>gtT	p.V140V	GDF5_ENST00000374369.3_Silent_p.V140V			P43026	GDF5_HUMAN	growth differentiation factor 5	140					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			AGGAGCTGGGGACAGATCCTG	0.647000													36	84					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31931244	31931244	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31931244C>T	ENST00000375394.2	+	14	1571	c.1458C>T	c.(1456-1458)ccC>ccT	p.P486P	SKIV2L_ENST00000544581.1_Silent_p.P293P	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	486						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						GCCCCGTGCCCCTGGAGCACT	0.562000													18	62					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158583514	158583514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158583514C>T	ENST00000368148.3	-	50	7166	c.6986G>A	c.(6985-6987)gGg>gAg	p.G2329E	SPTA1_ENST00000368147.3_Missense_Mutation_p.G2326E	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2329	EF-hand 2.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTCCTACCTCCCTGGATCCAC	0.493000													35	50					0	0	1	0	0
FUBP3	8939	broad.mit.edu	37	9	133507337	133507337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133507337C>T	ENST00000319725.9	+	15	1436	c.1361C>T	c.(1360-1362)cCt>cTt	p.P454L		NM_003934.1	NP_003925.1	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	454					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		AGTACCTTTCCTCCAAGGAGC	0.602000													26	82					0	0	1	0	0
PRSS54	221191	broad.mit.edu	37	16	58314292	58314292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58314292C>T	ENST00000219301.4	-	7	1418	c.1024G>A	c.(1024-1026)Gaa>Aaa	p.E342K	CCDC113_ENST00000219299.4_3'UTR|CCDC113_ENST00000443128.2_3'UTR|PRSS54_ENST00000567164.1_Missense_Mutation_p.E342K|PRSS54_ENST00000543437.1_Missense_Mutation_p.E243K	NM_001080492.1	NP_001073961.1	Q6PEW0	PRS54_HUMAN	protease, serine, 54	342					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CTGCCTGATTCCTTTACATCC	0.473000													24	70					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102737123	102737123	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102737123G>A	ENST00000532855.1	-	0	1063							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGGCCATAAGGAAGAAATTAA	0.358000													7	15					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165179939	165179939	+	Silent	SNP	C	C	T	rs146395249	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165179939C>T	ENST00000342310.3	-	6	1126	c.744G>A	c.(742-744)gcG>gcA	p.A248A	RP11-38C18.2_ENST00000457106.1_RNA|LMX1A_ENST00000367893.4_Silent_p.A248A|LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Silent_p.A248A	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	248	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					AGGTTACCTTCGCTCTCTGGT	0.473000													20	40					0	0	1	0	0
C1orf222	339457	broad.mit.edu	37	1	1920391	1920391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1920391G>A	ENST00000434971.2	-	3	121	c.89C>T	c.(88-90)cCg>cTg	p.P30L				Q69YW0	CA222_HUMAN	chromosome 1 open reading frame 222	64										breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)	11	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GTCAAACTCCGGATCCTCTAA	0.433000													16	47					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839611	27839611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27839611G>A	ENST00000356790.2	+	3	433	c.188G>A	c.(187-189)gGa>gAa	p.G63E		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	63										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AATCCCCATGGACTTCGGGAA	0.498000													6	8					0	0	1	0	0
CREB3L1	90993	broad.mit.edu	37	11	46342292	46342292	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:46342292C>T	ENST00000529193.1	+	12	2007	c.1556C>T	c.(1555-1557)tCc>tTc	p.S519F	CREB3L1_ENST00000288400.3_Missense_Mutation_p.S519F			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	519					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		ATCAAACTCTCCTAGGCCATG	0.592000			T	FUS	myxofibrosarcoma								9	13					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126746129	126746129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:126746129G>A	ENST00000274473.6	+	10	1233	c.966G>A	c.(964-966)gaG>gaA	p.E322E	MEGF10_ENST00000418761.2_Silent_p.E322E|MEGF10_ENST00000503335.2_Silent_p.E322E|MEGF10_ENST00000508365.1_Silent_p.E322E	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	322	EGF-like 6.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TCTGTGCTGAGACCTGCCAGT	0.562000													17	42					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47587925	47587925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47587925G>A	ENST00000172229.3	+	4	845	c.720G>A	c.(718-720)caG>caA	p.Q240Q	NGFR_ENST00000504201.1_Silent_p.Q146Q|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	240	Ser/Thr-rich.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GCAGCTCCCAGCCCGTGGTGA	0.617000													18	50					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76728481	76728481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76728481G>A	ENST00000369950.3	-	7	950	c.761C>T	c.(760-762)tCc>tTc	p.S254F	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	254	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TGGGGACTGGGAGTCAGCGAG	0.537000													9	78					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71977544	71977544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71977544C>T	ENST00000266674.5	+	18	2065	c.1754C>T	c.(1753-1755)tCc>tTc	p.S585F	LGR5_ENST00000536515.1_Missense_Mutation_p.S513F|LGR5_ENST00000540815.2_Missense_Mutation_p.S561F|RP11-186F10.2_ENST00000546601.1_RNA			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	585						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						GTTTTCAGATCCCCTCTGTAC	0.502000													36	117					0	0	1	0	0
KATNAL1	84056	broad.mit.edu	37	13	30801654	30801654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:30801654G>A	ENST00000380615.3	-	9	1209	c.1042C>T	c.(1042-1044)Cct>Tct	p.P348S	KATNAL1_ENST00000380617.3_Missense_Mutation_p.P348S	NM_032116.4	NP_115492.1	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	348						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)|urinary_tract(3)	19		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		ATTTTGGAAGGATCATCATTT	0.358000													10	82					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52708472	52708472	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52708472A>G	ENST00000399231.3	-	5	725	c.482T>C	c.(481-483)gTa>gCa	p.V161A	MYO5A_ENST00000553916.1_Missense_Mutation_p.V161A|MYO5A_ENST00000356338.6_Missense_Mutation_p.V161A|MYO5A_ENST00000399233.2_Missense_Mutation_p.V161A|MYO5A_ENST00000358212.6_Missense_Mutation_p.V161A	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	161	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTCTCCACTTACGATGATGGA	0.423000													31	83					0	0	1	0	0
TAP2	6891	broad.mit.edu	37	6	32782259	32782259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32782259C>T	ENST00000452392.2	-	14	2475	c.2302G>A	c.(2302-2304)Ggg>Agg	p.G768R	HLA-DOB_ENST00000438763.2_Missense_Mutation_p.G161R			Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										TCCTCCTGCCCATTCAGGAAC	0.532000													66	164					0	0	1	0	0
PGC	5225	broad.mit.edu	37	6	41710071	41710071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41710071C>T	ENST00000373025.3	-	5	666	c.604G>A	c.(604-606)Gag>Aag	p.E202K	PGC_ENST00000425343.2_Missense_Mutation_p.E202K	NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	202					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			AGGGCGCCCTCCTGCACCATG	0.642000													33	70					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94703957	94703957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94703957G>A	ENST00000304338.3	+	8	941	c.787G>A	c.(787-789)Gaa>Aaa	p.E263K		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	263						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						TTCTAGGGATGAAGGCAGCAG	0.348000													51	134					0	0	1	0	0
FCGR3A	2214	broad.mit.edu	37	1	161514664	161514664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161514664G>A	ENST00000367969.3	-	4	695	c.512C>T	c.(511-513)gCt>gTt	p.A171V	FCGR3A_ENST00000436743.1_Missense_Mutation_p.A135V|FCGR3A_ENST00000540048.1_Missense_Mutation_p.A135V|FCGR3A_ENST00000443193.1_Missense_Mutation_p.A170V	NM_000569.6	NP_000560.5	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	135	Ig-like C2-type 2.				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTTATGCAGAGCAGTGTTCTT	0.483000													16	52					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62019102	62019102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62019102C>T	ENST00000578147.1	-	24	4616	c.4540G>A	c.(4540-4542)Gat>Aat	p.D1514N	SCN4A_ENST00000435607.1_Missense_Mutation_p.D1514N			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1514					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	AACATATCATCGATGCCCGAC	0.547000													24	73					0	0	1	0	0
ZNF812	729648	broad.mit.edu	37	19	9801459	9801459	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9801459C>T	ENST00000457674.2	-	5	1238	c.720G>A	c.(718-720)gtG>gtA	p.V240V	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TATGAATTTTCACATGTGCAG	0.333000													27	57					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3731987	3731987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3731987G>A	ENST00000541714.2	+	6	1130	c.668G>A	c.(667-669)gGc>gAc	p.G223D	TJP3_ENST00000262968.9_Missense_Mutation_p.G242D|TJP3_ENST00000587686.1_Missense_Mutation_p.G242D|TJP3_ENST00000589378.1_Missense_Mutation_p.G232D|TJP3_ENST00000539908.2_Missense_Mutation_p.G187D|TJP3_ENST00000382008.3_Missense_Mutation_p.G223D	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	223	PDZ 2.					tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGATTCGGGCCTGGCTGCC	0.597000													16	57					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701183	143701183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143701183C>T	ENST00000408922.2	+	1	162	c.94C>T	c.(94-96)Ctt>Ttt	p.L32F		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TCTGATATTCCTTGTGGCCTA	0.488000													9	50					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74003240	74003240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74003240C>T	ENST00000301607.3	-	22	6299	c.6046G>A	c.(6046-6048)Gag>Aag	p.E2016K	EVPL_ENST00000586740.1_Missense_Mutation_p.E2038K	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	2016	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CGGTACCCCTCCAGTGCCGCT	0.692000													26	49					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	344305	344305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:344305C>T	ENST00000343164.4	-	7	834	c.782G>A	c.(781-783)gGa>gAa	p.G261E	SLC6A13_ENST00000445055.2_Missense_Mutation_p.G169E	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	261					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			AAACTGAATTCCTTGGGCTGC	0.557000													12	69					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56089407	56089407	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56089407C>A	ENST00000257880.7	-	15	2253	c.2034G>T	c.(2032-2034)aaG>aaT	p.K678N	ITGA7_ENST00000553804.1_Missense_Mutation_p.K638N|ITGA7_ENST00000394229.2_Missense_Mutation_p.K634N|ITGA7_ENST00000394230.2_Missense_Mutation_p.K638N|ITGA7_ENST00000347027.6_Missense_Mutation_p.K628N|ITGA7_ENST00000257879.6_Missense_Mutation_p.K634N|ITGA7_ENST00000555728.1_Missense_Mutation_p.K678N|ITGA7_ENST00000452168.2_Missense_Mutation_p.K541N			Q13683	ITA7_HUMAN	integrin, alpha 7	678					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CACAGCCTTGCTTCAGGAAGT	0.572000													20	57					1.10923e-09	1.11355e-09	1	1	0
TACR3	6870	broad.mit.edu	37	4	104511098	104511098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104511098G>A	ENST00000304883.2	-	5	1279	c.1139C>T	c.(1138-1140)tCc>tTc	p.S380F	RP11-297P16.3_ENST00000502936.1_RNA|RP11-297P16.3_ENST00000512401.1_RNA	NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	380						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		ATCATAGCTGGAAACTTTGAT	0.453000													19	69					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32812098	32812098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32812098C>T	ENST00000380250.3	+	44	6889	c.6393C>T	c.(6391-6393)tcC>tcT	p.S2131S		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCAAAATATCCATGGTGGATG	0.498000													22	96					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37333917	37333917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37333917G>A	ENST00000262825.5	+	14	2302	c.2085G>A	c.(2083-2085)aaG>aaA	p.K695K	CSF2RB_ENST00000536485.1_Silent_p.K636K|CSF2RB_ENST00000406230.1_Silent_p.K695K|CSF2RB_ENST00000403662.3_Silent_p.K689K	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	689					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	AGGACCAAAAGGACAGCCCTG	0.637000													5	40					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75078455	75078455	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75078455G>A	ENST00000326665.5	-	9	1257	c.1039C>T	c.(1039-1041)Ccc>Tcc	p.P347S	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.P150S	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	347										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AGACTGAAGGGGAAACCATGA	0.413000													20	44					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5042876	5042876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:5042876C>T	ENST00000574788.1	+	22	3635	c.1405C>T	c.(1405-1407)Ccc>Tcc	p.P469S	USP6_ENST00000332776.4_Missense_Mutation_p.P469S|USP6_ENST00000304328.5_Missense_Mutation_p.P152S|USP6_ENST00000250066.6_Missense_Mutation_p.P469S			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	469					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CCCTTGGTTCCCCCATTATGA	0.612000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								24	28					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255668	15255668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15255668G>A	ENST00000378116.4	-	8	1925	c.1919C>T	c.(1918-1920)tCc>tTc	p.S640F		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	640						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GATGGCCTGGGAAGACAGGGG	0.612000													14	56					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32010369	32010369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32010369G>A	ENST00000375244.3	-	40	12274	c.12073C>T	c.(12073-12075)Ccc>Tcc	p.P4025S	TNXB_ENST00000451343.1_Missense_Mutation_p.P454S|TNXB_ENST00000375247.2_Missense_Mutation_p.P4023S			P22105	TENX_HUMAN	tenascin XB	4070	Fibronectin type-III 32.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CTGGGGAAGGGGATCCGCAGC	0.701000													6	10					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154146656	154146656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:154146656G>A	ENST00000389740.2	-	1	848	c.749C>T	c.(748-750)tCc>tTc	p.S250F		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	250						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGGGGACAGGGAAACCACTCT	0.652000													9	54					0	0	1	0	0
DOK2	9046	broad.mit.edu	37	8	21766932	21766932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:21766932C>T	ENST00000276420.4	-	5	1387	c.1129G>A	c.(1129-1131)Gac>Aac	p.D377N	DOK2_ENST00000544659.1_Missense_Mutation_p.D223N	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	377					blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		CCAGCAGGGTCCCTGTCAGCT	0.607000													25	63					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61557763	61557763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61557763G>A	ENST00000290866.4	+	5	745	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	ACE_ENST00000538928.1_Missense_Mutation_p.E241K|ACE_ENST00000428043.1_Missense_Mutation_p.E241K|ACE_ENST00000584529.1_3'UTR	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	241	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGACGATCTGGAACACCTCTA	0.612000													28	75					0	0	1	0	0
FES	2242	broad.mit.edu	37	15	91436511	91436511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91436511C>T	ENST00000394302.1	+	14	1574	c.1489C>T	c.(1489-1491)Cca>Tca	p.P497S	FES_ENST00000394300.3_Intron|FES_ENST00000328850.3_Intron|FES_ENST00000450438.2_Intron|FES_ENST00000414248.2_Intron|FES_ENST00000444422.2_Intron			P07332	FES_HUMAN	feline sarcoma oncogene	631	SH2.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GGGGTCCTCCCCACCTGCAGG	0.692000													7	26					0	0	1	0	0
ATXN2	6311	broad.mit.edu	37	12	111923659	111923659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111923659G>A	ENST00000377617.3	-	17	2956	c.2795C>T	c.(2794-2796)tCt>tTt	p.S932F	ATXN2_ENST00000389153.4_Missense_Mutation_p.S667F|ATXN2_ENST00000542287.2_Missense_Mutation_p.S667F|ATXN2_ENST00000550104.1_Missense_Mutation_p.S932F|ATXN2_ENST00000535949.1_Missense_Mutation_p.S643F	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	932	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						TGGGGTAGTAGAAGGCTTTGG	0.398000													13	38					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146825865	146825865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:146825865C>T	ENST00000361727.3	+	7	1536	c.1020C>T	c.(1018-1020)atC>atT	p.I340I		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	340	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGGAAAGCATCAACTACAATG	0.403000										HNSCC(39;0.1)			48	143					0	0	1	0	0
CAPZA2	830	broad.mit.edu	37	7	116550294	116550294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:116550294C>T	ENST00000361183.2	+	7	653	c.514C>T	c.(514-516)Cgt>Tgt	p.R172C	CAPZA2_ENST00000458284.2_Missense_Mutation_p.S145L	NM_006136.2	NP_006127.1	P47755	CAZA2_HUMAN	capping protein (actin filament) muscle Z-line, alpha 2	172					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex	actin binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	13	all_cancers(3;8.53e-08)|all_epithelial(6;7.79e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)		GBM - Glioblastoma multiforme(2;5.01e-06)|STAD - Stomach adenocarcinoma(10;0.000512)|all cancers(2;0.00326)			AAGGAATGGTCGTTGGAGGTC	0.318000													23	45					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76573717	76573717	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:76573717A>C	ENST00000307431.8	+	21	3704	c.3319A>C	c.(3319-3321)Att>Ctt	p.I1107L	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.I1059L|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.I1111L|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.I1035L	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1108	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CCACATAATGATTAACAGAGA	0.348000													29	87					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85775660	85775660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:85775660C>T	ENST00000405615.2	+	1	29	c.29C>T	c.(28-30)tCc>tTc	p.S10F	CADM2_ENST00000383699.3_Intron|CADM2_ENST00000407528.2_Intron	NM_153184.3	NP_694854.2	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	0					adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		TGCAACCTTTCCTTGGTACCA	0.348000													50	144					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32622504	32622504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32622504C>T	ENST00000373625.3	+	3	282	c.189C>T	c.(187-189)ttC>ttT	p.F63F	KPNA6_ENST00000537234.1_Silent_p.F60F|KPNA6_ENST00000545542.1_Silent_p.F68F|KPNA6_ENST00000469790.1_3'UTR	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	63					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTGCCATGTTCGATAGTCTTC	0.453000													30	81					0	0	1	0	0
ZNF778	197320	broad.mit.edu	37	16	89293398	89293398	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89293398C>T	ENST00000433976.2	+	6	950	c.618C>T	c.(616-618)ttC>ttT	p.F206F	ZNF778_ENST00000306502.6_Silent_p.F164F|RP11-46C24.6_ENST00000563182.1_RNA	NM_001201407.1|NM_182531.3	NP_001188336.1|NP_872337.2	Q96MU6	ZN778_HUMAN	zinc finger protein 778	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|skin(2)	24				BRCA - Breast invasive adenocarcinoma(80;0.0269)		GGGAAGTGTTCCTTAATCAGT	0.502000													44	155					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974674	49974674	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49974674G>A	ENST00000555099.1	+	1	732	c.700G>A	c.(700-702)Gcc>Acc	p.A234T		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						AAGGCACGAAGCCCTCTCTAC	0.468000													57	72					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115805519	115805519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:115805519G>A	ENST00000374227.3	-	4	1406	c.1379C>T	c.(1378-1380)cCc>cTc	p.P460L	ZFP37_ENST00000555206.1_Missense_Mutation_p.P461L|ZFP37_ENST00000553380.1_Missense_Mutation_p.P475L			Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	460						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ACATTCAAAGGGTTTCTCACC	0.353000													17	48					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	38997699	38997699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38997699C>T	ENST00000400482.3	-	4	1623	c.1034G>A	c.(1033-1035)gGg>gAg	p.G345E	KCNJ6_ENST00000288309.6_Missense_Mutation_p.G345E	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	345					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	TTCGTAGAACCCGTCCTCCAG	0.557000													7	88					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33623339	33623339	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33623339C>T	ENST00000361680.2	+	1	342	c.264C>T	c.(262-264)gaC>gaT	p.D88D	WDR88_ENST00000592765.1_Silent_p.D88D|WDR88_ENST00000355868.3_Silent_p.D88D			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	88										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					GCGACCAGGACCCTCTCTCCA	0.652000													21	74					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57088523	57088523	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57088523C>T	ENST00000330619.8	+	6	1412	c.726C>T	c.(724-726)acC>acT	p.T242T	ZNF470_ENST00000391709.3_Silent_p.T242T|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AAATCTCAACCCTTACTCTTC	0.373000													21	67					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569435	241569435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241569435C>T	ENST00000319838.5	+	6	1008	c.66C>T	c.(64-66)ggC>ggT	p.G22G	GPR35_ENST00000438013.2_Silent_p.G53G|GPR35_ENST00000407714.1_Silent_p.G22G|GPR35_ENST00000430267.1_Silent_p.G22G|GPR35_ENST00000403859.1_Silent_p.G22G	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	22						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		TCAAGCTGGGCTTCTACGCCT	0.647000													31	65					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1064220	1064220	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1064220G>A	ENST00000264930.5	-	19	2628	c.2585C>T	c.(2584-2586)cCc>cTc	p.P862L		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	862					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CAGCAGGAAGGGCAGCAGCAT	0.692000													10	24					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200534713	200534713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200534713G>A	ENST00000367350.4	-	24	4184	c.3746C>T	c.(3745-3747)tCg>tTg	p.S1249L		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	1249	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						AAAATCTAACGAAGAACCAAT	0.323000													30	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579835	179579835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179579835G>A	ENST00000589042.1	-	90	26302	c.26078C>T	c.(26077-26079)tCt>tTt	p.S8693F	TTN_ENST00000342992.6_Missense_Mutation_p.S7449F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S8376F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8376	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAGTTCTCAGACATTATCTT	0.453000													88	239					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74593462	74593462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74593462C>T	ENST00000253159.8	+	9	1603	c.1405C>T	c.(1405-1407)Cta>Tta	p.L469L	ZNF236_ENST00000320610.9_Silent_p.L471L	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	469					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GTCACCGTTTCTACCTGGTAA	0.388000													11	32					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133760622	133760622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133760622C>T	ENST00000318560.5	+	11	3326	c.2945C>T	c.(2944-2946)cCc>cTc	p.P982L		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	982	F-actin-binding.|Pro-rich.			P -> PL (in Ref. 1; AAA51561).	actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GCCCCCGTTCCCTCCACGTTG	0.652000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								13	105					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30881934	30881934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:30881934G>A	ENST00000251071.5	-	8	2180	c.1430C>T	c.(1429-1431)cCt>cTt	p.P477L	CAPRIN2_ENST00000298892.5_Missense_Mutation_p.P477L|CAPRIN2_ENST00000308433.5_Missense_Mutation_p.P144L|CAPRIN2_ENST00000417045.1_Missense_Mutation_p.P477L|CAPRIN2_ENST00000395805.2_Missense_Mutation_p.P477L|CAPRIN2_ENST00000538387.1_5'UTR	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	477					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TTTGGATTTAGGTGTATCTTG	0.468000													62	125					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169511109	169511109	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169511109G>A	ENST00000367796.3	-	13	3435	c.3234C>T	c.(3232-3234)tcC>tcT	p.S1078S	F5_ENST00000367797.3_Silent_p.S1073S			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1073	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATGTTTCATTGGATTTATGAA	0.423000													77	266					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131864581	131864581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131864581C>T	ENST00000359827.3	-	20	4701	c.3739G>A	c.(3739-3741)Ggc>Agc	p.G1247S	PLXNA4_ENST00000321063.4_Missense_Mutation_p.G1247S			Q9HCM2	PLXA4_HUMAN	plexin A4	1247						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						ATGAGGAGGCCGCCAGCCACT	0.617000													11	17					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12760990	12760990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12760990G>A	ENST00000456935.2	-	17	2133	c.2093C>T	c.(2092-2094)tCc>tTc	p.S698F	MAN2B1_ENST00000221363.4_Missense_Mutation_p.S697F	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	698					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AACCACCTGGGAACACCAAGC	0.627000													14	134					0	0	1	0	0
TAAR2	9287	broad.mit.edu	37	6	132938624	132938624	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:132938624G>A	ENST00000275191.2	-	1	693	c.586C>T	c.(586-588)Cat>Tat	p.H196Y	TAAR2_ENST00000367931.1_Missense_Mutation_p.H241Y|TAAR2_ENST00000537809.1_Missense_Mutation_p.H196Y	NM_014626.3	NP_055441.2	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2	241						plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)	23	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		TTGATGGCATGAGCATGTTTT	0.383000													33	47					0	0	1	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117960368	117960368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117960368G>A	ENST00000310164.2	+	4	1668	c.1161G>A	c.(1159-1161)agG>agA	p.R387R		NM_173798.2	NP_776159.1	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	22						AGATGGAGAGGTCAAGAGTGG	0.498000													23	39					0	0	1	0	0
TMEM150B	284417	broad.mit.edu	37	19	55832399	55832399	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55832399C>T	ENST00000326652.4	-	3	188	c.6G>A	c.(4-6)tgG>tgA	p.W2*	TMEM150B_ENST00000438693.1_Nonsense_Mutation_p.W2*			A6NC51	T150B_HUMAN	transmembrane protein 150B	2						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						ACAGGTAGCCCCACATGCCGG	0.602000													11	19					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57257988	57257988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57257988G>A	ENST00000343433.6	-	2	578	c.498C>T	c.(496-498)gcC>gcT	p.A166A	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	166										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CCAGATGGATGGCCTTACTTC	0.483000													50	85					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33703274	33703274	+	Missense_Mutation	SNP	G	G	A	rs143961677	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33703274G>A	ENST00000336934.5	-	5	1656	c.1540C>T	c.(1540-1542)Cat>Tat	p.H514Y	STARD13_ENST00000255486.4_Missense_Mutation_p.H506Y|STARD13_ENST00000399365.3_Missense_Mutation_p.H396Y	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	514					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AATGTATCATGAGTTTGCAGT	0.468000													27	74					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7188219	7188219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7188219G>A	ENST00000542285.1	-	11	1728	c.1579C>T	c.(1579-1581)Cct>Tct	p.P527S				P00736	C1R_HUMAN	complement component 1, r subcomponent	579	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCGTTGTCAGGGAGGCAGATG	0.552000													18	31					0	0	1	0	0
BTNL3	10917	broad.mit.edu	37	5	180432608	180432608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180432608C>T	ENST00000342868.6	+	8	1321	c.1137C>T	c.(1135-1137)gtC>gtT	p.V379V		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	379	B30.2/SPRY.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GGTATTGGGTCCTCAGACTGA	0.502000													14	57					0	0	1	0	0
YIPF7	285525	broad.mit.edu	37	4	44626787	44626787	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:44626787G>A	ENST00000332990.5	-	5	527	c.511C>T	c.(511-513)Cag>Tag	p.Q171*		NM_182592.2	NP_872398.2	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	171						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(1)	12						TAACCAAACTGAACTTTTCCT	0.468000													6	15					0	0	1	0	0
ZG16B	124220	broad.mit.edu	37	16	2880270	2880270	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2880270G>A	ENST00000382280.3	+	1	101	c.22G>A	c.(22-24)Gag>Aag	p.E8K		NM_145252.2	NP_660295.2	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16B	8						extracellular region	sugar binding			central_nervous_system(1)|lung(2)|ovary(1)|prostate(1)	5						GGGGGCCCAGGAGAGTATAAA	0.677000													8	14					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142612498	142612498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142612498C>T	ENST00000265310.1	-	10	1613	c.1265G>A	c.(1264-1266)gGg>gAg	p.G422E		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	422					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity	p.G422V(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GAATGGCCCCCCAAGAATCGT	0.498000													13	137					0	0	1	0	0
CPSF6	11052	broad.mit.edu	37	12	69652866	69652866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:69652866C>T	ENST00000435070.2	+	6	1301	c.1191C>T	c.(1189-1191)ccC>ccT	p.P397P	CPSF6_ENST00000266679.8_Silent_p.P434P|CPSF6_ENST00000551516.1_Intron|CPSF6_ENST00000456847.3_Silent_p.P324P	NM_007007.2	NP_008938.2	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6, 68kDa	397	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(7)|lung(8)	16	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			ACTATGGCCCCCCTGGAAGGT	0.418000													10	77					0	0	1	0	0
FAM3B	54097	broad.mit.edu	37	21	42694777	42694777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42694777G>A	ENST00000398646.3	+	1	31	c.16G>A	c.(16-18)Ggg>Agg	p.G6R	FAM3B_ENST00000398652.3_Intron|FAM3B_ENST00000398647.3_Intron|FAM3B_ENST00000357985.2_Intron|FAM3B_ENST00000479810.2_Intron			P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	0					apoptosis|insulin secretion	extracellular space	cytokine activity			central_nervous_system(2)|endometrium(1)|lung(2)	5		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				AAGCCACAGGGGGGATGGGGA	0.642000													12	19					0	0	1	0	0
ZNF645	158506	broad.mit.edu	37	X	22292286	22292286	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:22292286G>A	ENST00000323684.1	+	1	1222	c.1178G>A	c.(1177-1179)tGg>tAg	p.W393*		NM_152577.3	NP_689790.1	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	393						intracellular	zinc ion binding			cervix(1)|endometrium(4)|large_intestine(8)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	27						TGGCCTGCATGGAAACGACTG	0.448000													25	39					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120655881	120655881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120655881G>A	ENST00000310396.5	+	3	879	c.412G>A	c.(412-414)Ggg>Agg	p.G138R	CPED1_ENST00000340646.5_Missense_Mutation_p.G138R|CPED1_ENST00000450913.2_Missense_Mutation_p.G138R|CPED1_ENST00000495036.1_3'UTR	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TGCTGGCCTAGGGCCGGGGCT	0.448000													10	25					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31241586	31241586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31241586C>T	ENST00000269197.5	+	5	362	c.362C>T	c.(361-363)tCg>tTg	p.S121L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CTAGTTTGTTCGAAGCAGGTA	0.373000													4	14					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76573658	76573658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:76573658C>T	ENST00000307431.8	+	21	3645	c.3260C>T	c.(3259-3261)cCt>cTt	p.P1087L	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.P1039L|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.P1091L|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.P1015L	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1088	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						TATCAAGAGCCTGATGTTGTT	0.348000													14	50					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003386	75003386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:75003386C>T	ENST00000373359.2	-	1	1693	c.1501G>A	c.(1501-1503)Gag>Aag	p.E501K		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	501	MAGE 2.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCCACAGCCTCCCTATATTGT	0.488000													30	16					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105923959	105923959	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105923959G>A	ENST00000357060.3	-	24	3254	c.3139C>T	c.(3139-3141)Cga>Tga	p.R1047*	WDR96_ENST00000428666.1_Nonsense_Mutation_p.R1048*	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1047								p.R1047*(1)		NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCTCGAATTCGAACATTTCTT	0.368000													12	31					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111057732	111057732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111057732C>T	ENST00000551590.1	+	2	468	c.312C>T	c.(310-312)gtC>gtT	p.V104V	TCTN1_ENST00000550703.2_Silent_p.V104V|TCTN1_ENST00000551555.2_3'UTR|TCTN1_ENST00000377654.3_5'UTR|TCTN1_ENST00000397655.3_Silent_p.V104V|TCTN1_ENST00000397659.4_Silent_p.V104V|TCTN1_ENST00000471804.2_Silent_p.V104V			Q2MV58	TECT1_HUMAN	tectonic family member 1	104					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						ATTTCAGTGTCTTTTCTGCCT	0.438000													38	113					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51503798	51503798	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51503798C>T	ENST00000600767.1	-	4	601	c.112G>A	c.(112-114)Gag>Aag	p.E38K	KLK8_ENST00000593490.1_Intron|KLK8_ENST00000291726.7_Missense_Mutation_p.E38K|CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000347619.4_Intron|KLK8_ENST00000320838.5_Intron|KLK8_ENST00000391806.2_Missense_Mutation_p.E83K			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	38	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GGTTGGCACTCATGACCCCCC	0.637000													30	83					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62818111	62818111	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62818111C>T	ENST00000582986.1	-	0	387					NR_024386.1																						TGATGGACTTCGATGTCTTCA	0.562000													17	36					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166959042	166959042	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:166959042G>A	ENST00000367872.4	+	2	445	c.201G>A	c.(199-201)aaG>aaA	p.K67K	MAEL_ENST00000367870.2_Intron	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	67					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						CTCAGGGAAAGGACCCTGGGC	0.502000													13	29					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28877987	28877987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28877987C>T	ENST00000337120.5	+	1	3863	c.572C>T	c.(571-573)cCc>cTc	p.P191L	SH2B1_ENST00000359285.5_Missense_Mutation_p.P191L|SH2B1_ENST00000538342.1_Intron|SH2B1_ENST00000395532.4_Missense_Mutation_p.P191L|SH2B1_ENST00000563674.1_Intron|SH2B1_ENST00000545570.1_Intron|SH2B1_ENST00000322610.8_Missense_Mutation_p.P191L	NM_001145812.1|NM_015503.2	NP_001139284.1|NP_056318.2	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	191	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Interaction with RAC1 (By similarity).|Required for NGF signaling (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						TCGTCAGGCCCCCCAGTCTTA	0.657000													7	85					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32183144	32183144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32183144G>A	ENST00000375023.3	-	12	2018	c.1880C>T	c.(1879-1881)cCc>cTc	p.P627L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	627	EGF-like 16.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						AGCACACAGGGGAACCTCACA	0.557000													6	17					0	0	1	0	0
TAL2	6887	broad.mit.edu	37	9	108425072	108425072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:108425072C>T	ENST00000334077.3	+	1	335	c.295C>T	c.(295-297)Cct>Tct	p.P99S		NM_005421.2	NP_005412.1	Q16559	TAL2_HUMAN	T-cell acute lymphocytic leukemia 2	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding										CTACCAGGTTCCTTCACCTGG	0.572000			T	TRB@	T-ALL								8	21					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160094107	160094107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160094107G>A	ENST00000361216.3	+	6	606	c.517G>A	c.(517-519)Gga>Aga	p.G173R	ATP1A2_ENST00000392233.3_Missense_Mutation_p.G173R|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	173					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GATCCGGGAGGGAGAGAAGAT	0.597000													7	14					0	0	1	0	0
WDR91	29062	broad.mit.edu	37	7	134890719	134890719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:134890719G>A	ENST00000354475.4	-	5	717	c.686C>T	c.(685-687)cCt>cTt	p.P229L	WDR91_ENST00000485942.1_5'UTR|WDR91_ENST00000344400.5_Missense_Mutation_p.P229L|WDR91_ENST00000423565.1_Missense_Mutation_p.P194L	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	229										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						GGAGACATAAGGAGGCAATTT	0.522000													55	161					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180036981	180036981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180036981G>A	ENST00000261937.6	-	28	3809	c.3731C>T	c.(3730-3732)gCt>gTt	p.A1244V	FLT4_ENST00000393347.3_Missense_Mutation_p.A1244V|FLT4_ENST00000502649.1_Missense_Mutation_p.A1244V	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1244					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity	p.A1244V(2)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	ACGGGTCTCAGCCCCTCTGGC	0.572000													47	130					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38913777	38913777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38913777C>T	ENST00000302328.3	-	20	3600	c.3402G>A	c.(3400-3402)gtG>gtA	p.V1134V	SCN11A_ENST00000456224.3_Silent_p.V1096V|SCN11A_ENST00000444237.2_Silent_p.V1134V|SCN11A_ENST00000450244.1_Silent_p.V1134V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1134					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TGAGGGTGGTCACAGAGACCT	0.473000													27	87					0	0	1	0	0
BRS3	680	broad.mit.edu	37	X	135574322	135574322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135574322C>T	ENST00000370648.3	+	3	1216	c.988C>T	c.(988-990)Ctc>Ttc	p.L330F		NM_001727.1	NP_001718.1	P32247	BRS3_HUMAN	bombesin-like receptor 3	330					adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(1)	23	Acute lymphoblastic leukemia(192;0.000127)					CCCCTTTGCTCTCTACTGGCT	0.478000													106	73					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134385	128134385	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:128134385G>A	ENST00000368250.1	-	5	1662	c.1164C>T	c.(1162-1164)tcC>tcT	p.S388S	THEMIS_ENST00000537166.1_Silent_p.S432S|THEMIS_ENST00000368248.2_Silent_p.S467S|THEMIS_ENST00000543064.1_Silent_p.S467S			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	467	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						CCTCTTCAATGGAAAGATCCC	0.473000													32	35					0	0	1	0	0
DEFB110	245913	broad.mit.edu	37	6	49989596	49989596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49989596G>A	ENST00000371148.2	-	1	98	c.53C>T	c.(52-54)cCa>cTa	p.P18L	DEFB110_ENST00000393660.2_Missense_Mutation_p.P18L	NM_001037497.1	NP_001032586.1	Q30KQ9	DB110_HUMAN	defensin, beta 110 locus	18					defense response to bacterium	extracellular region				endometrium(1)|lung(1)|ovary(1)	3	Lung NSC(77;0.042)					CATATTACCTGGTAAAATTGT	0.303000													14	50					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49001503	49001503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49001503C>T	ENST00000600059.1	-	11	3050	c.2823G>A	c.(2821-2823)gaG>gaA	p.E941E	LMTK3_ENST00000270238.3_Silent_p.E970E					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CCGCCGCCTTCTCCTCGATGC	0.642000													8	94					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23299694	23299694	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23299694G>A	ENST00000560464.1	-	0	4496																											GGAGTAGGCGGCATCATCCAT	0.592000													8	44					0	0	1	0	0
MICU3	286097	broad.mit.edu	37	8	16921710	16921710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16921710G>A	ENST00000318063.5	+	2	541	c.499G>A	c.(499-501)Gat>Aat	p.D167N		NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		GACTCCGTATGATTTTATTTT	0.348000													16	91					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168310314	168310314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168310314C>T	ENST00000519560.1	-	5	860	c.441G>A	c.(439-441)ggG>ggA	p.G147G	SLIT3_ENST00000332966.8_Silent_p.G147G|SLIT3_ENST00000404867.3_Silent_p.G147G	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	147					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTCGGGATCCCCTGGATCT	0.468000													15	46					0	0	1	0	0
ACTA1	58	broad.mit.edu	37	1	229568553	229568553	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:229568553G>A	ENST00000366684.3	-	3	306	c.204C>T	c.(202-204)acC>acT	p.T68T	ACTA1_ENST00000366683.2_Silent_p.T68T	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	68			T -> I (in NEM3).		muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GGTACTTCAGGGTCAGGATAC	0.582000													31	82					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45009349	45009349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:45009349G>A	ENST00000258787.7	-	11	1594	c.1458C>T	c.(1456-1458)acC>acT	p.T486T		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	486	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						GCATGTCCAGGGTCTGCAGGA	0.662000													45	110					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58131029	58131029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58131029C>T	ENST00000547588.1	-	1	1000	c.1001G>A	c.(1000-1002)gGg>gAg	p.G334E	AGAP2_ENST00000257897.3_Intron	NM_001122772.2	NP_001116244.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	334	Interaction with PLCG1 (By similarity).				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						TGCTCGGCCCCCCTCCCGGCC	0.677000													5	18					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24776027	24776027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24776027G>A	ENST00000221166.5	+	3	3441	c.2659G>A	c.(2659-2661)Gaa>Aaa	p.E887K	NEFM_ENST00000437366.2_Missense_Mutation_p.E848K|NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000433454.2_Missense_Mutation_p.E511K|NEFM_ENST00000518131.1_Missense_Mutation_p.E669K			P07197	NFM_HUMAN	neurofilament, medium polypeptide	887	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TGAAGAGCATGAAGAGACCTT	0.423000													48	105					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42154381	42154381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42154381G>A	ENST00000320955.6	-	44	7722	c.7495C>T	c.(7495-7497)Cct>Tct	p.P2499S		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2499					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GGGCTGCGAGGAGCGGGGCTC	0.622000													6	17					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7324365	7324365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7324365C>T	ENST00000318881.6	+	2	478	c.241C>T	c.(241-243)Ccg>Tcg	p.P81S	SYT9_ENST00000396716.2_Missense_Mutation_p.P49S	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	81						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CTGCTGGGTTCCGTGGCGAGA	0.542000													41	86					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165956930	165956930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165956930G>A	ENST00000360093.3	-	22	4339	c.3848C>T	c.(3847-3849)tCt>tTt	p.S1283F	SCN3A_ENST00000409101.3_Missense_Mutation_p.S1234F|SCN3A_ENST00000283254.7_Missense_Mutation_p.S1283F	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1283						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.S1283F(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GCTAACCAAAGAAACCTACAA	0.373000													7	34					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100754	8100754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:8100754C>T	ENST00000379328.3	+	3	1296	c.728C>T	c.(727-729)tCc>tTc	p.S243F	GATA3_ENST00000461472.1_3'UTR|GATA3_ENST00000346208.3_Missense_Mutation_p.S243F	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	243					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CTGGGCGGCTCCCCCACCGGC	0.672000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						20	44					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9017450	9017450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9017450G>A	ENST00000397910.4	-	26	38077	c.37874C>T	c.(37873-37875)cCt>cTt	p.P12625L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12627	SEA 4.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCCACTCCAGGGCTTTTGGG	0.572000													11	160					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81472121	81472121	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81472121G>A	ENST00000548058.1	+	1	1132	c.222G>A	c.(220-222)gaG>gaA	p.E74E	ACSS3_ENST00000261206.3_Silent_p.E74E			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	74						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CCGACCCCGAGAGGTTCTGGG	0.647000													6	64					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575371	136575371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136575371G>A	ENST00000264162.2	-	6	1257	c.1247C>T	c.(1246-1248)cCc>cTc	p.P416L		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	416	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGTGTTCAGGGGCCTGCGTGG	0.652000													46	85					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750032	142750032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142750032C>T	ENST00000418316.1	+	1	616	c.595C>T	c.(595-597)Ctg>Ttg	p.L199L		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					CTGGGACTTTCTGATGGCCTT	0.532000													72	153					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76787359	76787359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76787359C>T	ENST00000286719.7	-	15	2259	c.1903G>A	c.(1903-1905)Gaa>Aaa	p.E635K		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	635					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTCAGTTGTTCCTTGGCCAAG	0.498000													56	120					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407248	38407248	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38407248G>A	ENST00000322350.5	+	8	1493	c.1147_splice	c.e8+1	p.D383_splice	EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000336740.6_Splice_Site_p.D149_splice|EGFLAM_ENST00000354891.3_Splice_Site_p.D383_splice	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	383						cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					CTGCTCAGAAGGTAGGCCCTT	0.547000													12	30					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233150438	233150438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233150438C>T	ENST00000258229.8	-	28	5159	c.4925G>A	c.(4924-4926)gGa>gAa	p.G1642E	PCNXL2_ENST00000344698.2_Missense_Mutation_p.G294E	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1642						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGCGGCTGTTCCCAGAGCTCT	0.527000													23	61					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56088753	56088753	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56088753C>T	ENST00000257880.7	-	16	2356	c.2135_splice	c.e16-1	p.D713_splice	ITGA7_ENST00000553804.1_Splice_Site_p.D673_splice|ITGA7_ENST00000394229.2_Splice_Site_p.D669_splice|ITGA7_ENST00000394230.2_Splice_Site_p.D673_splice|ITGA7_ENST00000347027.6_Splice_Site_p.D663_splice|ITGA7_ENST00000257879.6_Splice_Site_p.D669_splice|ITGA7_ENST00000555728.1_Splice_Site_p.D713_splice|ITGA7_ENST00000452168.2_Splice_Site_p.D576_splice			Q13683	ITA7_HUMAN	integrin, alpha 7	713					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCATCCACATCCCTGGAGAGT	0.612000													14	29					0	0	1	0	0
INPP4A	3631	broad.mit.edu	37	2	99170840	99170840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99170840C>T	ENST00000074304.5	+	16	1862	c.1469C>T	c.(1468-1470)tCg>tTg	p.S490L	INPP4A_ENST00000409016.3_Missense_Mutation_p.S490L|INPP4A_ENST00000523221.1_Missense_Mutation_p.S490L|INPP4A_ENST00000545415.1_Missense_Mutation_p.S490L|INPP4A_ENST00000409540.3_Missense_Mutation_p.S490L|INPP4A_ENST00000409851.3_Missense_Mutation_p.S485L|INPP4A_ENST00000409463.1_Intron	NM_001134224.1	NP_001127696.1	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type I, 107kDa	490					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(1)|endometrium(9)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(4)|upper_aerodigestive_tract(4)	43						TCTCCCACTTCGACTGAGGAG	0.602000													9	20					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049412	70049412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70049412C>T	ENST00000330891.5	-	10	1508	c.1282G>A	c.(1282-1284)Gac>Aac	p.D428N	BEST3_ENST00000488961.1_Missense_Mutation_p.D215N|BEST3_ENST00000553096.1_Missense_Mutation_p.D322N|BEST3_ENST00000331471.4_Intron	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	428						chloride channel complex|plasma membrane	chloride channel activity	p.D428N(1)|p.D215N(1)		cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GGGCTGAGGTCATCTCGGGGT	0.592000													25	90					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31091248	31091248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31091248C>T	ENST00000332585.6	+	1	456	c.352C>T	c.(352-354)Ccc>Tcc	p.P118S	OSBP2_ENST00000407373.1_Intron|OSBP2_ENST00000403222.3_Intron|OSBP2_ENST00000446658.2_Missense_Mutation_p.P118S|OSBP2_ENST00000382310.3_Missense_Mutation_p.P118S	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	118					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						AGGGGCTGGGCCCTTCACTAA	0.687000													27	49					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115161063	115161063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115161063C>T	ENST00000393274.1	-	8	1893	c.1268G>A	c.(1267-1269)gGg>gAg	p.G423E	DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Missense_Mutation_p.G366E|DENND2C_ENST00000393277.1_Missense_Mutation_p.G423E	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	423										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCTTCTTCCCTCTTTTAGA	0.343000													20	72					0	0	1	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862124	25862124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25862124G>A	ENST00000397060.4	-	4	546	c.437C>T	c.(436-438)tCt>tTt	p.S146F	SLC17A3_ENST00000361703.6_Intron|SLC17A3_ENST00000360657.3_Intron	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	290					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						TGCAAACAAAGAAATGCCAAC	0.483000													6	15					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75167505	75167505	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:75167505G>A	ENST00000336926.6	-	31	3128	c.3102C>T	c.(3100-3102)acC>acT	p.T1034T	HIP1_ENST00000434438.2_Silent_p.T983T	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	1034					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						ATTCTTTTTCGGTTACCACTT	0.418000			T	PDGFRB	CMML								10	200					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140984946	140984946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140984946C>T	ENST00000298296.1	+	7	1402	c.1402C>T	c.(1402-1404)Ctc>Ttc	p.L468F	MAGEC3_ENST00000409007.1_Missense_Mutation_p.L170F|MAGEC3_ENST00000536088.1_Missense_Mutation_p.L170F|MAGEC3_ENST00000544766.1_Missense_Mutation_p.L170F|MAGEC3_ENST00000443323.2_Missense_Mutation_p.L90F	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	468	MAGE 2.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					GCAGTTTCTTCTCCTCAAATA	0.463000													33	23					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6125769	6125769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6125769C>T	ENST00000261405.5	-	30	5478	c.5224G>A	c.(5224-5226)Gac>Aac	p.D1742N		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1742	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CATGGCACGTCAATGGTGGTG	0.542000													30	49					0	0	1	0	0
RP11-166N6.3	0	broad.mit.edu	37	3	150659371	150659371	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:150659371G>A	ENST00000569170.1	-	1	159	c.160C>T	c.(160-162)Cag>Tag	p.Q54*	CLRN1-AS1_ENST00000476886.1_RNA|CLRN1_ENST00000328863.4_Missense_Mutation_p.S144L|RP11-166N6.2_ENST00000469268.1_RNA|CLRN1_ENST00000295911.2_Missense_Mutation_p.S68L|CLRN1_ENST00000327047.1_Missense_Mutation_p.S144L																							GTACTTACCTGAAATGAAGCT	0.363000													16	57					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313818	54313818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54313818G>A	ENST00000324134.6	-	3	1263	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	NLRP12_ENST00000391772.1_Silent_p.F365F|NLRP12_ENST00000535162.1_Silent_p.F365F|NLRP12_ENST00000391773.1_Silent_p.F365F|NLRP12_ENST00000354278.3_Silent_p.F365F|NLRP12_ENST00000391775.3_Silent_p.F365F|NLRP12_ENST00000351894.4_Silent_p.F365F|NLRP12_ENST00000345770.5_Silent_p.F365F	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	365	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTGCCTCAGAGAAGCCCAGGA	0.542000													90	226					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110466714	110466714	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110466714C>T	ENST00000329608.6	+	6	1862	c.1471C>T	c.(1471-1473)Ccg>Tcg	p.P491S	CSF1_ENST00000420111.2_Missense_Mutation_p.P193S|CSF1_ENST00000369802.3_Missense_Mutation_p.P491S|CSF1_ENST00000344188.5_Missense_Mutation_p.P375S|CSF1_ENST00000369801.1_Missense_Mutation_p.P375S	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	491					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		ATCCTTCAGCCCGCAGCTCCA	0.622000													36	66					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502084	90502084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90502084C>T	ENST00000325643.5	+	4	2748	c.2682C>T	c.(2680-2682)ttC>ttT	p.F894F		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		TTCCCATTTTCCTGGGAAAAC	0.597000													6	33					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57330048	57330048	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57330048A>T	ENST00000326441.9	-	8	1055	c.692T>A	c.(691-693)gTg>gAg	p.V231E	PEG3_ENST00000423103.2_Missense_Mutation_p.V231E|ZIM2_ENST00000593711.1_Missense_Mutation_p.V106E|ZIM2_ENST00000601070.1_Missense_Mutation_p.V106E|PEG3_ENST00000593695.1_Missense_Mutation_p.V105E|PEG3_ENST00000598410.1_Missense_Mutation_p.V106E|ZIM2_ENST00000599935.1_Missense_Mutation_p.V106E|ZIM2_ENST00000391708.3_Missense_Mutation_p.V106E|ZIM2_ENST00000221722.5_Missense_Mutation_p.V106E	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	231					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GAGGTCCACCACATTTTGGTA	0.478000													30	84					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35506332	35506332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35506332G>A	ENST00000217320.3	+	2	108	c.64G>A	c.(64-66)Gag>Aag	p.E22K	TLDC2_ENST00000602922.1_Missense_Mutation_p.E22K	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		CCTGTCTggggaggagggtaa	0.622000													10	76					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47278193	47278193	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47278193G>A	ENST00000271153.4	+	4	429	c.393G>A	c.(391-393)ggG>ggA	p.G131G	CYP4B1_ENST00000371919.4_Silent_p.G116G|CYP4B1_ENST00000452782.2_5'UTR|CYP4B1_ENST00000371923.4_Silent_p.G131G			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	131					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TTCTTGAGGGGCCCAAGTGGT	0.587000													11	25					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143013383	143013383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143013383C>T	ENST00000343257.2	+	1	165	c.78C>T	c.(76-78)ccC>ccT	p.P26P		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	26					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					AGTATATGCCCTTTGAACACT	0.637000													30	147					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100268916	100268916	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100268916C>T	ENST00000515683.1	-	0	457				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	ATGCGAACTTCATGAGCCTTA	0.338000													22	57					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150932029	150932029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:150932029G>A	ENST00000309170.3	-	3	388	c.76C>T	c.(76-78)Cct>Tct	p.P26S	P2RY14_ENST00000424796.2_Missense_Mutation_p.P26S|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	26						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TACAGCACAGGAATGATCTGC	0.458000													35	107					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9045590	9045590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9045590G>A	ENST00000397910.4	-	5	36244	c.36041C>T	c.(36040-36042)gCc>gTc	p.A12014V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12016	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTCTCAGAGGCCAAGGTGGA	0.403000													5	10					0	0	1	0	0
SPDYE3	441272	broad.mit.edu	37	7	99917408	99917408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99917408G>A	ENST00000332397.6	+	9	1751	c.1567G>A	c.(1567-1569)Gtt>Att	p.V523I	SPDYE3_ENST00000437326.2_Missense_Mutation_p.V146I	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	523										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						CAGGGCTTGGGTTTCCCCGGA	0.632000													19	75					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940775	22940775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22940775C>T	ENST00000397104.3	-	5	1662	c.1663G>A	c.(1663-1665)Gag>Aag	p.E555K	ZNF99_ENST00000596209.1_Missense_Mutation_p.E646K					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TAGGGTTTCTCTCCAGTATGA	0.368000													24	65					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45744123	45744123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:45744123G>A	ENST00000297323.7	+	17	2747	c.2725G>A	c.(2725-2727)Gaa>Aaa	p.E909K		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	909					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	AAAGCTCATGGAAAAAGACTT	0.502000													30	82					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897906	175897906	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175897906G>A	ENST00000359240.3	+	5	1900	c.1230G>A	c.(1228-1230)gaG>gaA	p.E410E	ADAM29_ENST00000404450.4_Silent_p.E410E|ADAM29_ENST00000445694.1_Silent_p.E410E|ADAM29_ENST00000514159.1_Silent_p.E410E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	410	Disintegrin.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AAGGAGAAGAGTGTGACTGTG	0.428000													32	107					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36875124	36875124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36875124C>T	ENST00000301807.6	-	21	6065	c.4168G>A	c.(4168-4170)Gac>Aac	p.D1390N	TRANK1_ENST00000429976.2_Missense_Mutation_p.D1940N|TRANK1_ENST00000428977.2_Missense_Mutation_p.D1390N	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1940					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAGTCCTTGTCGGCAGTGAGC	0.587000													10	27					0	0	1	0	0
VSIG1	340547	broad.mit.edu	37	X	107310234	107310234	+	Silent	SNP	C	C	T	rs138849840	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107310234C>T	ENST00000415430.3	+	4	551	c.390C>T	c.(388-390)aaC>aaT	p.N130N	VSIG1_ENST00000485533.1_3'UTR|VSIG1_ENST00000217957.5_Silent_p.N94N	NM_001170553.1	NP_001164024.1	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	94	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17						CAGGGTCCAACGATCCAGGTA	0.438000													6	61					0	0	1	0	0
C11orf70	85016	broad.mit.edu	37	11	101951951	101951951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101951951G>A	ENST00000434758.2	+	6	642	c.614G>A	c.(613-615)cGa>cAa	p.R205Q	C11orf70_ENST00000526781.1_Missense_Mutation_p.R205Q	NM_032930.2	NP_116319.2	Q9BRQ4	CK070_HUMAN	chromosome 11 open reading frame 70	205										breast(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|skin(2)	12	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		TTTAGTGTTCGAAAGAATCCT	0.299000													16	59					0	0	1	0	0
MSANTD2	79684	broad.mit.edu	37	11	124637768	124637768	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124637768G>A	ENST00000526629.1	-	3	1741	c.294C>T	c.(292-294)atC>atT	p.I98I	MSANTD2_ENST00000239614.4_Silent_p.I276I|MSANTD2_ENST00000524950.1_3'UTR|MSANTD2_ENST00000374979.3_Silent_p.I328I			Q6P1R3	CK061_HUMAN	Myb/SANT-like DNA-binding domain containing 2	328																	AATGGTAACGGATATCCTCTT	0.468000													40	118					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13830182	13830182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13830182C>T	ENST00000265104.4	-	37	6306	c.6202G>A	c.(6202-6204)Gga>Aga	p.G2068R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2068	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ACATTATCTCCATCAGTAAAG	0.378000									Kartagener syndrome				14	49					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540207	169540207	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169540207G>A	ENST00000340806.6	+	1	498	c.498G>A	c.(496-498)aaG>aaA	p.K166K		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	166										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						ACCAGACCAAGCTGAGGGAGA	0.493000													13	98					0	0	1	0	0
CHRDL1	91851	broad.mit.edu	37	X	109924794	109924794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:109924794C>T	ENST00000218054.4	-	10	1262	c.1066G>A	c.(1066-1068)Gag>Aag	p.E356K	CHRDL1_ENST00000372042.1_Missense_Mutation_p.E358K|CHRDL1_ENST00000482160.1_Missense_Mutation_p.E278K|CHRDL1_ENST00000434224.1_Missense_Mutation_p.E277K|CHRDL1_ENST00000372045.1_Missense_Mutation_p.E350K|CHRDL1_ENST00000394797.4_Missense_Mutation_p.E356K|CHRDL1_ENST00000444321.2_Missense_Mutation_p.E357K	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	350					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						TCCCCATCCTCCATGAATACA	0.473000													72	39					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38843566	38843566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38843566C>T	ENST00000359357.3	+	51	7423	c.7169C>T	c.(7168-7170)tCa>tTa	p.S2390L	DNAH8_ENST00000449981.2_Missense_Mutation_p.S2607L|DNAH8_ENST00000441566.1_Missense_Mutation_p.S2354L					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CCTAAAGGCTCAAATCAAACC	0.358000													20	56					0	0	1	0	0
PTHLH	5744	broad.mit.edu	37	12	28116336	28116336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:28116336G>A	ENST00000535992.1	-	3	815	c.469C>T	c.(469-471)Cta>Tta	p.L157L	RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000201015.4_Silent_p.L157L|PTHLH_ENST00000354417.3_Silent_p.L157L|PTHLH_ENST00000395868.3_Silent_p.L157L|PTHLH_ENST00000545234.1_Silent_p.L157L|PTHLH_ENST00000395872.1_Silent_p.L157L|PTHLH_ENST00000538310.1_Silent_p.L157L|PTHLH_ENST00000539239.1_Silent_p.L157L			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	157					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					TCCCCTTCTAGCCCACTCCCA	0.572000													24	55					0	0	1	0	0
TAB1	10454	broad.mit.edu	37	22	39824183	39824183	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39824183C>T	ENST00000216160.6	+	10	1364	c.1302C>T	c.(1300-1302)ctC>ctT	p.L434L	TAB1_ENST00000331454.3_Silent_p.L434L	NM_006116.2	NP_006107.1	Q15750	TAB1_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 1	434					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|urinary_tract(1)	14						CCCCCACCCTCACCAAGTAAG	0.637000													14	50					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189849638	189849638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189849638G>A	ENST00000304636.3	+	2	402	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	COL3A1_ENST00000317840.5_Missense_Mutation_p.E78K	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	78	VWFC.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCCCAACCCAGAAATTCCATT	0.418000													16	65					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42459061	42459061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42459061G>A	ENST00000318006.5	-	14	1590	c.1428C>T	c.(1426-1428)tgC>tgT	p.C476C	VPS39_ENST00000348544.4_Silent_p.C487C	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	487					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		CCTCGATGTGGCAGTGATTGT	0.552000													47	104					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262033	45262033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:45262033G>A	ENST00000303230.4	-	8	2720	c.2663C>T	c.(2662-2664)tCa>tTa	p.S888L		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	888						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TCATAAATTTGAAGCAAATCG	0.438000													37	173					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88584281	88584281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88584281G>A	ENST00000339673.6	+	6	1450	c.1351G>A	c.(1351-1353)Gaa>Aaa	p.E451K	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.E435K|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	451					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CCATTCTGAGGAAGACGACAG	0.532000													7	59					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367630	107367630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107367630G>A	ENST00000542196.1	-	1	321	c.279C>T	c.(277-279)tcC>tcT	p.S93S		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						AGCCAGAAAGGGAAATGGTCT	0.517000													26	99					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74347431	74347431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:74347431G>A	ENST00000377044.4	-	7	1938	c.1399C>T	c.(1399-1401)Cct>Tct	p.P467S	TMEM2_ENST00000377066.5_Missense_Mutation_p.P404S	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	467						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AGGAACTGAGGGGTTTCTGGT	0.408000													22	34					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85434298	85434298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:85434298C>T	ENST00000393217.2	+	3	224	c.163C>T	c.(163-165)Cac>Tac	p.H55Y		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	55										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		ATCAGTTCTTCACTGTATTAA	0.303000													23	92					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70942322	70942322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70942322C>T	ENST00000357250.6	-	36	2625	c.2467G>A	c.(2467-2469)Ggg>Agg	p.G823R	COL9A1_ENST00000370499.4_Missense_Mutation_p.G580R|RP1-149L1.1_ENST00000522264.1_RNA|COL9A1_ENST00000320755.7_Missense_Mutation_p.G580R|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	823	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CCAGGGGGCCCCTTAATGCCC	0.552000													12	141					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086691	100086691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100086691C>T	ENST00000423930.1	+	4	1506	c.1347C>T	c.(1345-1347)ctC>ctT	p.L449L	NYAP1_ENST00000300179.2_Silent_p.L449L|NYAP1_ENST00000454988.1_Silent_p.L392L			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	449	Pro-rich.																ccgccTTGCTCCCCGGCCCCC	0.721000													3	6					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	134980913	134980913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134980913C>T	ENST00000304613.3	+	2	152	c.131C>T	c.(130-132)tCc>tTc	p.S44F	KNDC1_ENST00000530127.1_3'UTR|KNDC1_ENST00000368572.2_Missense_Mutation_p.S44F|KNDC1_ENST00000368571.2_5'UTR			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	44	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GACATCCTCTCCCTGCGGGAC	0.711000													3	4					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228175562	228175562	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228175562G>A	ENST00000396578.3	+	51	4988	c.4826G>A	c.(4825-4827)cGa>cAa	p.R1609Q	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1609	Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GAAGAATTCCGAGCCAGCCCA	0.463000													19	83					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139429023	139429023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:139429023C>T	ENST00000272641.3	-	2	370	c.264G>A	c.(262-264)acG>acA	p.T88T		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	88	II.				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		CCTGAATCTCCGTGATGTTGG	0.483000													76	41					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072407	9072407	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9072407C>T	ENST00000397910.4	-	3	15242	c.15039G>A	c.(15037-15039)ttG>ttA	p.L5013L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5015	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTCACATCCAATTGTGAAA	0.483000													21	58					0	0	1	0	0
MRM1	79922	broad.mit.edu	37	17	34964690	34964690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34964690C>T	ENST00000250156.7	+	5	1140	c.901C>T	c.(901-903)Cac>Tac	p.H301Y	MRM1_ENST00000585770.1_Missense_Mutation_p.H106Y	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	301					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		AATTCTTCTTCACTCCATTTG	0.542000													81	106					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40717020	40717020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40717020C>T	ENST00000298910.7	+	38	5626	c.5568C>T	c.(5566-5568)gcC>gcT	p.A1856A		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1856					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CTCAGATTGCCCCTGACTTGA	0.338000													25	69					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24579067	24579067	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24579067G>A	ENST00000358321.3	+	2	380	c.119G>A	c.(118-120)gGg>gAg	p.G40E		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	40	SMB.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						GCCCTGGACGGGCCATGTTCC	0.632000													18	182					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30139662	30139662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30139662G>A	ENST00000376694.4	+	7	1403	c.934G>A	c.(934-936)Gac>Aac	p.D312N	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	312	B30.2/SPRY.				mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						TCTCTCGGAAGACAGGAAGTC	0.652000													5	14					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105168911	105168911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105168911G>A	ENST00000428173.2	+	19	3506	c.3203G>A	c.(3202-3204)cGa>cAa	p.R1068Q	NRK_ENST00000243300.9_Missense_Mutation_p.R1067Q			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1067							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						GGAGTCGTTCGAACCAGTGAA	0.493000										HNSCC(51;0.14)			36	18					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233394686	233394686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233394686G>A	ENST00000536614.1	+	6	575	c.547G>A	c.(547-549)Ggt>Agt	p.G183S	CHRND_ENST00000543200.1_Silent_p.R204R|CHRND_ENST00000258385.3_Silent_p.R219R|CHRND_ENST00000457943.2_Intron			Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	498					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GGCCGGCCAGGGTCAACGTGG	0.642000													19	101					0	0	1	0	0
OR10H3	26532	broad.mit.edu	37	19	15852698	15852698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15852698C>T	ENST00000305892.1	+	1	496	c.496C>T	c.(496-498)Cac>Tac	p.H166Y		NM_013938.1	NP_039226.1	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H, member 3	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						GATGGTTTTTCACCTCACTTT	0.502000													46	98					0	0	1	0	0
FAM98A	25940	broad.mit.edu	37	2	33810711	33810711	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33810711G>A	ENST00000403368.1	-	7	843	c.774C>T	c.(772-774)tcC>tcT	p.S258S	FAM98A_ENST00000441530.2_Silent_p.S63S|FAM98A_ENST00000238823.8_Silent_p.S258S	NM_015475.3	NP_056290.3	Q8NCA5	FA98A_HUMAN	family with sequence similarity 98, member A	259										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(1)	24	all_hematologic(175;0.115)					TAGTTTTAGGGGATAAGACTG	0.398000													35	102					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89266243	89266243	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89266243G>A	ENST00000464162.1	-	0	43																											GCTGAGCGGGGACCCTCATGT	0.577000													35	183					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922679	24922679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922679C>T	ENST00000329468.2	+	1	2139	c.1665C>T	c.(1663-1665)tcC>tcT	p.S555S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1									p.S555S(1)									CAGTCATTTCCACTGTCACAA	0.488000													40	139					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21422680	21422680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21422680C>T	ENST00000307378.6	-	16	2535	c.1815G>A	c.(1813-1815)ccG>ccA	p.P605P	SLCO1A2_ENST00000537524.1_Silent_p.P473P|SLCO1A2_ENST00000458504.1_Silent_p.P473P|SLCO1A2_ENST00000452078.1_Silent_p.P605P	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	605					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						TTAGTGCTGCCGGCAATCCGA	0.343000													30	102					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44253805	44253805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44253805C>T	ENST00000371505.4	-	3	864	c.742G>A	c.(742-744)Gat>Aat	p.D248N	TMEM151B_ENST00000438774.2_Intron|TCTE1_ENST00000371503.3_Missense_Mutation_p.D95N|TCTE1_ENST00000371504.1_Missense_Mutation_p.D95N	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	248										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCCTTGACATCGTACACCAGG	0.592000													21	67					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153431388	153431388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153431388C>T	ENST00000368723.3	-	2	212	c.102G>A	c.(100-102)acG>acA	p.T34T	S100A7_ENST00000368722.1_Silent_p.T34T	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	34	EF-hand 1.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCTTCATCATCGTCAGCAGGC	0.468000													48	139					0	0	1	0	0
BTN1A1	696	broad.mit.edu	37	6	26509185	26509185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26509185C>T	ENST00000244513.6	+	7	1430	c.1364C>T	c.(1363-1365)cCc>cTc	p.P455L		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	455	B30.2/SPRY.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						TTCTCTGGCCCCCTCCGGCCC	0.478000													18	71					0	0	1	0	0
SLC35F1	222553	broad.mit.edu	37	6	118588247	118588247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:118588247C>T	ENST00000360388.4	+	4	768	c.567C>T	c.(565-567)atC>atT	p.I189I		NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	189					transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		TCATCGGCATCGTTGTCTGCA	0.532000													94	160					0	0	1	0	0
EFNA4	1945	broad.mit.edu	37	1	155039326	155039326	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155039326G>A	ENST00000368409.3	+	2	327	c.234G>A	c.(232-234)gtG>gtA	p.V78V	EFNA4_ENST00000427683.2_Silent_p.V78V|EFNA4_ENST00000359751.4_Silent_p.V78V|EFNA3_ENST00000556931.1_Intron|EFNA3_ENST00000505139.1_Intron	NM_005227.2	NP_005218.1			ephrin-A4											breast(1)|endometrium(1)|large_intestine(1)|ovary(1)	4	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TGTACATGGTGGACTGGCCAG	0.612000													20	43					0	0	1	0	0
TTC25	83538	broad.mit.edu	37	17	40091482	40091482	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40091482C>T	ENST00000591658.1	+	0	195							Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25							cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				TCTTTACCTTCAGGATGGAGA	0.537000													11	24					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987943	50987943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50987943G>A	ENST00000395676.2	+	1	1482	c.1348G>A	c.(1348-1350)Ggg>Agg	p.G450R		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	450										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGCCTGCCGTGGGGACATCTA	0.672000													32	77					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374055	31374055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31374055C>T	ENST00000268296.4	+	12	1461	c.1340C>T	c.(1339-1341)gCc>gTc	p.A447V	ITGAX_ENST00000562522.1_Missense_Mutation_p.A447V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	447					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						AGGATGAAGGCCGAAGTCACG	0.647000													12	35					0	0	1	0	0
HAT1	8520	broad.mit.edu	37	2	172803273	172803273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:172803273C>T	ENST00000264108.4	+	3	194	c.158C>T	c.(157-159)cCt>cTt	p.P53L	SLC25A12_ENST00000472748.1_Intron|HAT1_ENST00000392584.1_Intron	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	53					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			ACTTTCTTTCCTGAGTATACC	0.279000													29	99					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203017798	203017798	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203017798C>T	ENST00000367240.2	+	11	1839	c.1312C>T	c.(1312-1314)Ctg>Ttg	p.L438L	PPFIA4_ENST00000447715.2_Silent_p.L442L|PPFIA4_ENST00000295706.4_5'UTR|PPFIA4_ENST00000414050.2_Silent_p.L145L			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	132					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CAACGAGCGTCTGCAGCTCCA	0.652000													4	22					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71155355	71155355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71155355C>T	ENST00000283228.2	-	4	975	c.523G>A	c.(523-525)Gga>Aga	p.G175R	PTPRR_ENST00000342084.4_Missense_Mutation_p.G63R	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	175					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TCAGAAATTCCTGTTTTTCGG	0.343000													34	137					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57719769	57719769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57719769G>A	ENST00000333493.4	+	11	1632	c.1471G>A	c.(1471-1473)Ggg>Agg	p.G491R	GPR97_ENST00000327655.6_Missense_Mutation_p.G281R|GPR97_ENST00000450388.3_Missense_Mutation_p.G371R|RP11-405F3.4_ENST00000563062.1_RNA	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	491					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TGTGACATGGGGGTTGGCCAT	0.617000													22	54					0	0	1	0	0
ASPHD2	57168	broad.mit.edu	37	22	26830241	26830241	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26830241G>A	ENST00000215906.5	+	2	1098	c.660G>A	c.(658-660)atG>atA	p.M220I		NM_020437.4	NP_065170.2	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	220					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	16						GATGGAAAATGAACAGCACCC	0.532000													20	61					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13423582	13423582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13423582G>A	ENST00000360228.5	-	12	1568	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F	CACNA1A_ENST00000573710.2_Silent_p.F524F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	524					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CTAAGAAAATGAATTCTGCAT	0.458000													11	38					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154744764	154744764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154744764G>A	ENST00000271915.3	-	3	1450	c.1135C>T	c.(1135-1137)Cct>Tct	p.P379S	KCNN3_ENST00000358505.2_Missense_Mutation_p.P66S|KCNN3_ENST00000361147.4_Missense_Mutation_p.P74S	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	384						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TACTCGCCAGGAATGGGGTGG	0.597000													8	30					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101759873	101759873	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:101759873G>A	ENST00000251127.6	-	22	2625	c.2544C>T	c.(2542-2544)aaC>aaT	p.N848N		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	848						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCCGGCAAAAGTTTCTGAACC	0.502000													18	93					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87487623	87487623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87487623G>A	ENST00000327946.7	-	10	1607	c.1522C>T	c.(1522-1524)Ctc>Ttc	p.L508F	GRID1_ENST00000536331.1_Missense_Mutation_p.L79F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	508						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TTGCTGATGAGCTCCCCGATC	0.537000										Multiple Myeloma(13;0.14)			17	70					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969464	47969464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47969464C>T	ENST00000236877.6	-	2	592	c.197G>A	c.(196-198)gGt>gAt	p.G66D	SLC8A2_ENST00000542837.1_Intron|SLC8A2_ENST00000539381.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	66					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CGCCTTGTCACCCAGCGACGG	0.657000													14	48					0	0	1	0	0
SLC20A1	6574	broad.mit.edu	37	2	113416991	113416991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113416991C>T	ENST00000272542.3	+	8	1798	c.1259C>T	c.(1258-1260)tCc>tTc	p.S420F		NM_005415.4	NP_005406.3	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate transporter), member 1	420					phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|skin(1)|urinary_tract(3)	28						AGCTATACTTCCTATACCATG	0.463000													31	80					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29104781	29104781	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29104781G>A	ENST00000261590.8	+	8	1153	c.944G>A	c.(943-945)gGa>gAa	p.G315E		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	315	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TTTGCATCAGGAAATGAAGGA	0.373000													12	81					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47682051	47682051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47682051G>A	ENST00000283303.2	+	6	1328	c.1070G>A	c.(1069-1071)aGg>aAg	p.R357K	GPR115_ENST00000327753.3_Missense_Mutation_p.R357K|GPR115_ENST00000371220.1_Missense_Mutation_p.R414K	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	357	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						TCCAAGAAAAGGAGATGGGAT	0.448000													21	65					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6954416	6954416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:6954416G>A	ENST00000383032.1	+	16	1885	c.1238G>A	c.(1237-1239)gGg>gAg	p.G413E	TBL1Y_ENST00000346432.3_Missense_Mutation_p.G413E|TBL1Y_ENST00000355162.2_Missense_Mutation_p.G413E	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	413					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						AGCCCCACCGGGCCTGCCACC	0.537000													13	13					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032457	30032457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30032457G>A	ENST00000328224.6	-	2	3002	c.1769C>T	c.(1768-1770)cCc>cTc	p.P590L		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	590						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CAAATTAGAGGGGAGGTATGG	0.433000													18	46					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149002610	149002610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:149002610C>T	ENST00000355292.3	-	9	3214	c.2852G>A	c.(2851-2853)cGa>cAa	p.R951Q	NR3C2_ENST00000512865.1_Missense_Mutation_p.R830Q|NR3C2_ENST00000344721.4_Missense_Mutation_p.R947Q|NR3C2_ENST00000511528.1_Missense_Mutation_p.R951Q|NR3C2_ENST00000358102.3_Missense_Mutation_p.R947Q|NR3C2_ENST00000342437.4_3'UTR			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	947	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ATGGGACTCTCGGAAGGTGTA	0.602000													21	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575645	179575645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179575645C>T	ENST00000589042.1	-	98	28403	c.28179G>A	c.(28177-28179)ggG>ggA	p.G9393G	TTN_ENST00000342992.6_Silent_p.G8149G|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.G9076G|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9076	Ig-like 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGGTTCTTCCCCTCTAATA	0.453000													24	58					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27135420	27135420	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27135420G>A	ENST00000343060.4	-	1	173	c.112C>T	c.(112-114)Cag>Tag	p.Q38*	HOTAIRM1_ENST00000495032.1_RNA|HOXA1_ENST00000355633.5_Nonsense_Mutation_p.Q38*	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	38						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GCGCACGACTGGAAAGTTGTA	0.617000											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	46	109					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102495961	102495961	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102495961G>A	ENST00000260228.2	-	1	102	c.90C>T	c.(88-90)tcC>tcT	p.S30S	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	30					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AGGTCCTGGGGGAGGCTGCAA	0.532000													18	75					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703087	4703087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4703087G>A	ENST00000396950.3	-	2	1094	c.855C>T	c.(853-855)gtC>gtT	p.V285V		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGGATTGATGACAGGAGGCA	0.512000													22	47					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247608109	247608109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247608109C>T	ENST00000366497.2	+	8	3606	c.2826C>T	c.(2824-2826)ctC>ctT	p.L942L	NLRP3_ENST00000366496.2_Silent_p.L942L|NLRP3_ENST00000336119.3_Silent_p.L999L|NLRP3_ENST00000348069.2_Silent_p.L885L|NLRP3_ENST00000391828.3_Silent_p.L999L|NLRP3_ENST00000391827.2_Silent_p.L942L	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	999					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGAGCTGCCTCCTGCAGAACC	0.567000													5	47					0	0	1	0	0
ZNF557	79230	broad.mit.edu	37	19	7076403	7076403	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7076403C>T	ENST00000414706.1	+	5	605	c.132C>T	c.(130-132)acC>acT	p.T44T	ZNF557_ENST00000252840.6_Silent_p.T44T|ZNF557_ENST00000439035.2_Silent_p.T37T	NM_001044387.1|NM_001044388.1|NM_024341.2	NP_001037852.1|NP_001037853.1|NP_077317.2	Q8N988	ZN557_HUMAN	zinc finger protein 557	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17				Lung(535;0.179)		GCTTGGTGACCTTTGAGGATG	0.582000													45	111					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24181469	24181469	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24181469G>A	ENST00000265769.4	+	9	953	c.843G>A	c.(841-843)ggG>ggA	p.G281G	ADAM28_ENST00000540823.1_Silent_p.G48G|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Silent_p.G281G|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000518516.1_3'UTR|ADAM28_ENST00000397649.3_Silent_p.G28G|RP11-624C23.1_ENST00000519689.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	281	Peptidase M12B.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AATGGAGGGGGAGTGTTCTCT	0.398000													32	72					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488233	24488233	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:24488233T>G	ENST00000264463.4	-	12	2413	c.1906A>C	c.(1906-1908)Aga>Cga	p.R636R	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	636					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TTTCGCTGTCTTTTCAGAGCT	0.393000										HNSCC(23;0.051)			24	55					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81110911	81110911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81110911C>T	ENST00000228644.3	+	1	221	c.69C>T	c.(67-69)tcC>tcT	p.S23S		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	23					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						GCATACCGTCCCCCGAGGGTG	0.617000													26	28					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99658619	99658619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:99658619C>T	ENST00000373034.4	-	2	3866	c.2191G>A	c.(2191-2193)Gga>Aga	p.G731R	PCDH19_ENST00000255531.7_Intron|PCDH19_ENST00000420881.2_Intron	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	731					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CTGTTTTGTCCTTTTATAAAA	0.428000													8	4					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	114141190	114141190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:114141190G>A	ENST00000276198.1	+	6	1317	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	HTR2C_ENST00000371950.3_Missense_Mutation_p.R165Q|HTR2C_ENST00000371951.1_Missense_Mutation_p.E197K	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	197					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	ACTGAGGGACGAAGAAAAGGT	0.443000													23	90					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110717531	110717531	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110717531C>T	ENST00000331565.4	+	5	1187	c.702C>T	c.(700-702)gcC>gcT	p.A234A		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	234					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TCCTCGTGGCCTGGAGCATCG	0.602000													23	43					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22025612	22025612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:22025612G>A	ENST00000261200.4	-	16	2144	c.2145C>T	c.(2143-2145)ctC>ctT	p.L715L	ABCC9_ENST00000261201.4_Silent_p.L715L|ABCC9_ENST00000345162.2_Silent_p.L679L|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	715	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGATGGCAAGGAGAAGAGAGG	0.423000													77	172					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088494	94088494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94088494C>T	ENST00000553484.1	+	31	5135	c.4981C>T	c.(4981-4983)Cct>Tct	p.P1661S	UNC79_ENST00000555664.1_Missense_Mutation_p.P1639S|UNC79_ENST00000393151.2_Missense_Mutation_p.P1639S|UNC79_ENST00000256339.4_Missense_Mutation_p.P1462S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1639						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GCCTCTTCCCCCTCTCAGAAT	0.517000													35	113					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447415	24447415	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24447415G>A	ENST00000270800.1	-	7	1643	c.1605C>T	c.(1603-1605)tcC>tcT	p.S535S		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	535						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GACACACAAGGGACTCCAGCA	0.612000													6	76					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739233	38739233	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38739233C>T	ENST00000449082.2	-	27	5477	c.5478G>A	c.(5476-5478)gaG>gaA	p.E1826E		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1826					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TAAACTTCTCCTCCATATTTG	0.428000													19	91					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41515243	41515243	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41515243C>T	ENST00000324071.4	+	5	772	c.765C>T	c.(763-765)acC>acT	p.T255T	CYP2B6_ENST00000330446.5_Intron|CYP2B6_ENST00000593831.1_Intron	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	255					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ACCGTGAAACCCTGGACCCCA	0.542000													42	93					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413290	124413290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124413290C>T	ENST00000306842.2	-	1	285	c.261G>A	c.(259-261)agG>agA	p.R87R		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		TGATGTTCTTCCTTGAGACAA	0.433000													24	81					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332847	70332847	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70332847C>T	ENST00000338508.4	-	32	3553	c.3554G>A	c.(3553-3555)aGc>aAc	p.S1185N	SHANK2_ENST00000449833.2_Missense_Mutation_p.S589N|SHANK2_ENST00000423696.2_Missense_Mutation_p.S805N|SHANK2_ENST00000409161.1_Missense_Mutation_p.S588N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	805					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGCTGGGCTGCTCTCGGGCCC	0.692000													26	63					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74825629	74825629	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:74825629C>T	ENST00000358399.3	+	4	504	c.411C>T	c.(409-411)acC>acT	p.T137T	GDA_ENST00000376989.3_Silent_p.T112T|GDA_ENST00000477618.1_3'UTR|GDA_ENST00000238018.4_Silent_p.T137T|GDA_ENST00000545168.1_Silent_p.T63T|GDA_ENST00000376986.1_Silent_p.T95T	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	137					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		ATGGAACAACCACAGCTTGTT	0.418000													11	51					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31611188	31611188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31611188G>A	ENST00000170150.3	+	16	1571	c.1376G>A	c.(1375-1377)tGa>tAa	p.*459*		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	0						extracellular region	lipid binding										TACCAGAGCTGAGGCAAGACC	0.567000													9	58					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857232	9857232	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9857232G>A	ENST00000396573.2	-	14	4478	c.4169C>T	c.(4168-4170)tCg>tTg	p.S1390L	GRIN2A_ENST00000404927.2_Missense_Mutation_p.R1276C|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R1276C|GRIN2A_ENST00000330684.3_Missense_Mutation_p.S1390L|GRIN2A_ENST00000396575.2_Missense_Mutation_p.S1390L|GRIN2A_ENST00000535259.1_Missense_Mutation_p.R1119C	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1390					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGATGGCAACGAGTGTTTGTA	0.552000													17	67					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29627145	29627145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29627145G>A	ENST00000376894.4	+	2	256	c.138G>A	c.(136-138)ggG>ggA	p.G46G	MOG_ENST00000431798.2_Silent_p.G46G|MOG_ENST00000483013.1_Intron|MOG_ENST00000376917.3_Silent_p.G46G|MOG_ENST00000416766.2_Silent_p.G46G|MOG_ENST00000490427.1_Intron|MOG_ENST00000396701.2_Silent_p.G46G|MOG_ENST00000396704.3_Silent_p.G46G|MOG_ENST00000376891.4_Silent_p.G46G|MOG_ENST00000469603.1_3'UTR|MOG_ENST00000376888.2_Intron|MOG_ENST00000494692.1_Silent_p.G46G|MOG_ENST00000376898.3_Silent_p.G46G|MOG_ENST00000376902.3_Silent_p.G46G|MOG_ENST00000533330.2_Silent_p.G46G			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	46	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						CTCTGGTCGGGGATGAAGTGG	0.547000													59	200					0	0	1	0	0
FLYWCH2	114984	broad.mit.edu	37	16	2946512	2946512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2946512C>T	ENST00000396958.3	+	3	442	c.62C>T	c.(61-63)tCc>tTc	p.S21F	FLYWCH2_ENST00000572006.1_Missense_Mutation_p.S21F|FLYWCH2_ENST00000293981.6_Missense_Mutation_p.S21F	NM_001142500.1|NM_138439.2	NP_001135972.1|NP_612448.1	Q96CP2	FWCH2_HUMAN	FLYWCH family member 2	21										central_nervous_system(1)|lung(3)|ovary(1)|skin(1)	6						CAGGAGCCATCCCCCAAGCCA	0.652000													15	82					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17046493	17046493	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17046493G>A	ENST00000492551.1	-	0	159					NR_026567.1																						CTCAGGGAGGGGAAGTCTCCT	0.632000													13	153					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68641181	68641181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68641181G>A	ENST00000423218.2	-	10	1213	c.1118C>T	c.(1117-1119)tCg>tTg	p.S373L	ITGA11_ENST00000315757.7_Missense_Mutation_p.S373L			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	373					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	CACCACGTGCGAGGAAAAGCC	0.567000													6	15					0	0	1	0	0
CALB1	793	broad.mit.edu	37	8	91075654	91075654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:91075654C>T	ENST00000265431.3	-	7	667	c.486G>A	c.(484-486)ctG>ctA	p.L162L	CALB1_ENST00000518457.1_Silent_p.L105L	NM_004929.2	NP_004920.1	P05937	CALB1_HUMAN	calbindin 1, 28kDa	162	EF-hand 4.					nucleus	calcium ion binding|vitamin D binding			breast(1)|kidney(1)|lung(8)|pancreas(1)	11			BRCA - Breast invasive adenocarcinoma(11;0.00953)			CAGTTAATTCCAGCTTCCCAT	0.313000													12	51					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50225432	50225432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50225432G>A	ENST00000002829.3	+	19	2726	c.2242G>A	c.(2242-2244)Ggt>Agt	p.G748S	SEMA3F_ENST00000434342.1_Missense_Mutation_p.G717S|SEMA3F_ENST00000413852.1_Missense_Mutation_p.G649S	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	748					axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		GTACTGCCAGGGTTACTGGCG	0.701000													9	14					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51887531	51887531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51887531G>A	ENST00000453097.2	+	20	2961	c.2744G>A	c.(2743-2745)gGa>gAa	p.G915E	SLC4A8_ENST00000358657.3_Missense_Mutation_p.G942E	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	915					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		CTTTACATGGGAGTTTCTTCA	0.443000													33	169					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345534	92345534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:92345534C>T	ENST00000377067.3	+	3	791	c.419C>T	c.(418-420)tCg>tTg	p.S140L		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	140						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GCTGCTGCTTCGGTTCAGGAG	0.408000													94	105					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85970858	85970858	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85970858C>T	ENST00000372117.3	+	13	1525	c.1422C>T	c.(1420-1422)tcC>tcT	p.S474S	CDHR1_ENST00000440770.2_Intron|CDHR1_ENST00000332904.3_Silent_p.S474S	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	474	Cadherin 5.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						AGTTCGACTCCCTCTACTACG	0.582000													40	90					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106772153	106772153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:106772153C>T	ENST00000228347.4	+	8	827	c.605C>T	c.(604-606)tCa>tTa	p.S202L	POLR3B_ENST00000539066.1_Missense_Mutation_p.S144L	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	202					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						GTTGGAGCTTCAGTTACCAGG	0.408000													50	102					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44387268	44387268	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44387268T>A	ENST00000371477.3	+	9	1474	c.1175T>A	c.(1174-1176)tTc>tAc	p.F392Y		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	392	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAGAGTGACTTCTCAGGTGTA	0.428000													36	95					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161162403	161162403	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161162403C>T	ENST00000308192.9	+	17	2142	c.2079C>T	c.(2077-2079)gtC>gtT	p.V693V		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	693	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ATTATGTGGTCGCTGACCGGA	0.473000													24	39					0	0	1	0	0
RPAP2	79871	broad.mit.edu	37	1	92798992	92798992	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92798992G>A	ENST00000370343.3	+	9	1609	c.1500G>A	c.(1498-1500)caG>caA	p.Q500Q		NM_024813.2	NP_079089.2	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	500						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	22		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		CCCAGAACCAGATTAGAAAAC	0.328000													14	78					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110031617	110031617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110031617C>T	ENST00000369870.3	+	7	947	c.932C>T	c.(931-933)tCc>tTc	p.S311F		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	311										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		GAGCGCCCCTCCCAGGAGCTC	0.617000													16	47					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150842649	150842649	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150842649C>T	ENST00000370357.4	+	15	2411	c.2166C>T	c.(2164-2166)acC>acT	p.T722T		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	722						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					GCCAACCCACCTACCATCAGG	0.567000													36	52					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416279	178416279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178416279G>A	ENST00000231188.5	-	5	1318	c.1140C>T	c.(1138-1140)acC>acT	p.T380T	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Silent_p.T380T	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	380					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TGCATTTGCGGGTGGAATCGT	0.617000													10	46					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53666508	53666508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53666508C>T	ENST00000257934.4	+	6	1464	c.1373C>T	c.(1372-1374)tCt>tTt	p.S458F	ESPL1_ENST00000552462.1_Missense_Mutation_p.S458F	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	458					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CCTGCAGCTTCTTACACCAGT	0.537000													128	389					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113084920	113084920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113084920C>T	ENST00000393845.2	-	19	2747	c.2681G>A	c.(2680-2682)aGg>aAg	p.R894K	WDR52_ENST00000295868.2_Missense_Mutation_p.R894K	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	894										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						CATGTCTTTCCTTAGCATAAA	0.303000													44	129					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147016541	147016541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147016541G>A	ENST00000265272.5	-	11	2068	c.1601C>T	c.(1600-1602)gCt>gTt	p.A534V	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.A492V|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.A534V	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	534						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTTTCTGAGCCAGAGTCGC	0.502000													27	254					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10894144	10894144	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:10894144G>A	ENST00000283141.6	+	3	419	c.123G>A	c.(121-123)caG>caA	p.Q41Q	RP11-637O19.3_ENST00000480294.1_3'UTR|SYCP2L_ENST00000543878.1_5'UTR	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	41						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			AAGGATTTCAGAAAATAAAAG	0.308000													4	30					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228473972	228473972	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228473972G>A	ENST00000570156.2	+	39	10559	c.10485G>A	c.(10483-10485)cgG>cgA	p.R3495R	OBSCN_ENST00000366707.4_Silent_p.R185R|OBSCN_ENST00000422127.1_Silent_p.R3066R|OBSCN_ENST00000359599.6_Silent_p.R1913R|OBSCN_ENST00000284548.11_Silent_p.R3066R|OBSCN_ENST00000366709.4_Silent_p.R185R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2528	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGACCCTGCGGCAGCTGGCGC	0.657000													3	8					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112705447	112705447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112705447G>A	ENST00000448454.2	+	8	984	c.984G>A	c.(982-984)acG>acA	p.T328T	PALM2_ENST00000374531.2_Silent_p.T294T|PALM2-AKAP2_ENST00000374530.3_Intron|AKAP2_ENST00000510514.5_Intron|AKAP2_ENST00000555236.1_Intron|PALM2_ENST00000314527.4_Silent_p.T326T|PALM2-AKAP2_ENST00000302798.7_Intron|PALM2_ENST00000483909.1_Silent_p.T292T					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						AAGAGGAGACGAAAAAGGTGC	0.502000													34	82					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922879	24922879	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922879C>T	ENST00000329468.2	+	1	2339	c.1865C>T	c.(1864-1866)tCc>tTc	p.S622F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GTCTACACATCCCCACTTCCA	0.483000													40	80					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22263514	22263514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:22263514C>T	ENST00000379374.4	+	21	2700	c.2135C>T	c.(2134-2136)cCc>cTc	p.P712L	PHEX_ENST00000418858.3_Missense_Mutation_p.P415L|PHEX_ENST00000537599.1_Intron|PHEX_ENST00000535894.1_Missense_Mutation_p.P615L	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	712					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						GCTCACAGTCCCCCTCAGTTT	0.502000													18	96					0	0	1	0	0
AGA	175	broad.mit.edu	37	4	178358631	178358631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:178358631G>A	ENST00000264595.2	-	5	677	c.550C>T	c.(550-552)Cca>Tca	p.P184S	AGA_ENST00000506853.1_5'UTR	NM_000027.3|NM_001171988.1	NP_000018.2|NP_001165459.1	P20933	ASPG_HUMAN	aspartylglucosaminidase	184					asparagine catabolic process via L-aspartate|protein deglycosylation|protein maturation	endoplasmic reticulum|intermediate filament cytoskeleton|lysosome|microtubule cytoskeleton	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|skin(2)	16		all_lung(41;1.27e-09)|Lung NSC(41;1.1e-08)|Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Hepatocellular(41;0.148)|all_neural(102;0.164)|Colorectal(36;0.245)		all cancers(43;1.37e-22)|Epithelial(43;3.86e-20)|OV - Ovarian serous cystadenocarcinoma(60;3.8e-11)|Colorectal(24;6.98e-05)|GBM - Glioblastoma multiforme(59;0.000362)|COAD - Colon adenocarcinoma(29;0.000462)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0328)|READ - Rectum adenocarcinoma(43;0.163)		ATACCAGGTGGTTTGTAGGGT	0.348000													13	26					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98545880	98545880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98545880C>T	ENST00000359863.4	+	33	4773	c.4564C>T	c.(4564-4566)Cat>Tat	p.H1522Y	TRRAP_ENST00000355540.3_Missense_Mutation_p.H1504Y|TRRAP_ENST00000446306.3_Missense_Mutation_p.H1503Y	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1522					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAACCTTTTTCATCTGATCCC	0.438000													38	74					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30976046	30976046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:30976046G>A	ENST00000295055.8	-	10	1136	c.960C>T	c.(958-960)ttC>ttT	p.F320F	CAPN13_ENST00000534090.2_Silent_p.F320F	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	320	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					ATTTCTGTTGGAAATCTTGAC	0.448000													30	97					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54965696	54965696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54965696C>T	ENST00000326764.5	+	6	993	c.514C>T	c.(514-516)Ccc>Tcc	p.P172S	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	135							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		GCCCTCAAATCCCCCACATGG	0.682000													21	23					0	0	1	0	0
VRK3	51231	broad.mit.edu	37	19	50511003	50511003	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50511003G>A	ENST00000599538.1	-	5	1034	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	VRK3_ENST00000594092.1_Nonsense_Mutation_p.Q124*|VRK3_ENST00000377011.2_Nonsense_Mutation_p.Q74*|VRK3_ENST00000316763.3_Nonsense_Mutation_p.Q124*|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000594948.1_Nonsense_Mutation_p.Q124*|VRK3_ENST00000601341.1_Nonsense_Mutation_p.Q74*|VRK3_ENST00000601912.1_Nonsense_Mutation_p.Q74*|VRK3_ENST00000593919.1_Nonsense_Mutation_p.Q124*|VRK3_ENST00000443401.2_5'UTR			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	124						nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		CTGGTCTTCTGAGGGCTACCC	0.602000													34	121					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46343634	46343634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:46343634G>A	ENST00000256413.3	+	10	1709	c.1414G>A	c.(1414-1416)Gag>Aag	p.E472K	CTIF_ENST00000382998.4_Missense_Mutation_p.E474K	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	472	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						GCAGGACGTGGAGCGCTGGCT	0.672000													19	87					0	0	1	0	0
NOLC1	9221	broad.mit.edu	37	10	103912198	103912198	+	Missense_Mutation	SNP	C	C	T	rs145813353		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103912198C>T	ENST00000405356.1	+	1	266	c.31C>T	c.(31-33)Ccc>Tcc	p.P11S	NOLC1_ENST00000603742.1_5'UTR|NOLC1_ENST00000605788.1_Missense_Mutation_p.P11S|NOLC1_ENST00000488254.2_Missense_Mutation_p.P11S			Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	11	LisH.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		CCGCGTGGTTCCCAGCGACCT	0.622000													14	114					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886395	3886395	+	Missense_Mutation	SNP	G	G	A	rs140162397		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3886395G>A	ENST00000319331.3	+	2	831	c.70G>A	c.(70-72)Gag>Aag	p.E24K	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	24						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TTCATTAACCGAGTCTTCCAT	0.473000													6	77					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14765924	14765924	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14765924C>T	ENST00000253673.5	-	6	547	c.447G>A	c.(445-447)tgG>tgA	p.W149*	EMR3_ENST00000443157.2_Intron|EMR3_ENST00000599900.1_Intron|EMR3_ENST00000344373.4_Nonsense_Mutation_p.W97*	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	149					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						CTTCTGTTCTCCATAAAGTCT	0.368000													14	101					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71125438	71125438	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71125438C>T	ENST00000299213.8	-	3	499	c.429G>A	c.(427-429)cgG>cgA	p.R143R		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	143	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						TTCTCCAGTCCCGTGTAAGAT	0.483000													24	80					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70919657	70919657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70919657C>T	ENST00000264436.3	-	7	1027	c.583G>A	c.(583-585)Gtg>Atg	p.V195M	ADD2_ENST00000407644.2_Missense_Mutation_p.V195M|ADD2_ENST00000430656.1_Missense_Mutation_p.V211M|ADD2_ENST00000355733.3_Missense_Mutation_p.V195M|ADD2_ENST00000413157.2_Missense_Mutation_p.V195M	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	195					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CCCTTCTCCACCACCTCTCCC	0.617000													14	33					0	0	1	0	0
KLHL5	51088	broad.mit.edu	37	4	39082836	39082836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39082836C>T	ENST00000261425.3	+	4	832	c.680C>T	c.(679-681)tCc>tTc	p.S227F	KLHL5_ENST00000508137.2_Missense_Mutation_p.S86F|KLHL5_ENST00000261426.5_Missense_Mutation_p.S212F|KLHL5_ENST00000359687.2_Missense_Mutation_p.S273F|KLHL5_ENST00000381930.3_Missense_Mutation_p.S273F|KLHL5_ENST00000504108.1_Missense_Mutation_p.S273F	NM_001007075.2	NP_001007076.1	Q96PQ7	KLHL5_HUMAN	kelch-like family member 5	273	BTB.					cytoplasm|cytoskeleton	actin binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29						TCGTTGTGGTCCTTGATCCAG	0.333000													29	64					0	0	1	0	0
ACTA2	59	broad.mit.edu	37	10	90695041	90695041	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90695041C>T	ENST00000458208.1	-	9	1547	c.1073G>A	c.(1072-1074)tGg>tAg	p.W358*	ACTA2_ENST00000224784.6_Nonsense_Mutation_p.W358*|ACTA2-AS1_ENST00000437930.3_RNA|STAMBPL1_ENST00000371927.3_Intron	NM_001141945.1	NP_001135417.1	P62736	ACTA_HUMAN	actin, alpha 2, smooth muscle, aorta	358					response to virus	cytosol	ATP binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(2)	17		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TTTGCTGATCCACATCTGCTG	0.517000											OREG0020356	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	148					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122377072	122377072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122377072G>A	ENST00000334010.7	-	2	811	c.390C>T	c.(388-390)ctC>ctT	p.L130L	CADPS2_ENST00000449022.2_Silent_p.L130L|CADPS2_ENST00000313070.7_Silent_p.L130L|CADPS2_ENST00000412584.2_Silent_p.L130L	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	130					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						TTTCCCCATTGAGGAAGGCCT	0.398000													17	29					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55294968	55294968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55294968G>A	ENST00000336077.6	+	7	888	c.848G>A	c.(847-849)gGa>gAa	p.G283E	KIR2DL3_ENST00000434419.2_Missense_Mutation_p.G283E|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL1_ENST00000291633.7_Missense_Mutation_p.G309E|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	283					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		GAGTCTGCAGGAAACAGAACA	0.517000													45	119					0	0	1	0	0
PI3	5266	broad.mit.edu	37	20	43803611	43803611	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43803611G>A	ENST00000243924.3	+	1	95	c.48G>A	c.(46-48)ggG>ggA	p.G16G		NM_002638.3	NP_002629.1	P19957	ELAF_HUMAN	peptidase inhibitor 3, skin-derived	16					copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity			large_intestine(1)|lung(5)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				TCATCGCTGGGACGCTGGTTC	0.577000													20	57					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7152762	7152762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7152762G>A	ENST00000341500.5	-	10	2245	c.2206C>T	c.(2206-2208)Ctg>Ttg	p.L736L	INSR_ENST00000302850.5_Silent_p.L736L	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	736					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACGTTGTGCAGGTAATCCTCA	0.542000													62	156					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155287561	155287561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155287561C>T	ENST00000357232.3	-	5	494	c.495G>A	c.(493-495)gtG>gtA	p.V165V	DCHS2_ENST00000339452.1_Silent_p.V759V	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	165	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCTCCAGGTCCACACGAACAA	0.468000													10	17					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142574200	142574200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142574200G>A	ENST00000359396.3	-	6	968	c.723C>T	c.(721-723)ctC>ctT	p.L241L	RP11-114L10.2_ENST00000438839.1_RNA	NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	241					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					TGAAAGGGGTGAGACCCTGGT	0.572000													25	32					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1513857	1513857	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1513857G>A	ENST00000421627.2	+	3	1133	c.999G>A	c.(997-999)caG>caA	p.Q333Q	RP11-666I19.2_ENST00000518063.1_RNA	NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	412					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AGGTACCTCAGGATGAGTGGG	0.507000													7	22					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861992	52861992	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52861992G>A	ENST00000343457.3	-	4	1202	c.1196C>T	c.(1195-1197)cCt>cTt	p.P399L		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	399						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GTCAACATAAGGCCTTGTGAA	0.547000													25	68					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24473886	24473886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24473886G>A	ENST00000230036.1	-	6	561	c.451C>T	c.(451-453)Cac>Tac	p.H151Y	GPLD1_ENST00000474784.1_5'UTR	NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	151						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TAGGAGCCGTGAAAATCAATC	0.398000													7	24					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36859727	36859727	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36859727C>T	ENST00000279024.4	-	5	2019	c.1747_splice	c.e5-1	p.G583_splice		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	583										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GTCCCGGCCACCTGGAGGACA	0.632000													3	4					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115143510	115143510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115143510C>T	ENST00000393274.1	-	14	2512	c.1887G>A	c.(1885-1887)atG>atA	p.M629I	DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Missense_Mutation_p.M572I|DENND2C_ENST00000393277.1_Missense_Mutation_p.M629I	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	629	DENN.									NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGGAGCTTCCATGACACTTC	0.423000													38	84					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48614394	48614394	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:48614394C>T	ENST00000297423.4	+	13	2269	c.1885C>T	c.(1885-1887)Cca>Tca	p.P629S	SPIDR_ENST00000518074.1_Missense_Mutation_p.P569S|SPIDR_ENST00000517693.1_Missense_Mutation_p.P104S|SPIDR_ENST00000541342.1_Missense_Mutation_p.P559S|SPIDR_ENST00000521214.1_3'UTR	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		TTACCAGCCTCCAGTTACCCG	0.448000													95	248					0	0	1	0	0
TMEM50A	23585	broad.mit.edu	37	1	25666982	25666982	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:25666982C>T	ENST00000374358.4	+	2	558	c.5C>T	c.(4-6)tCt>tTt	p.S2F	TMEM50A_ENST00000480937.1_3'UTR	NM_014313.3	NP_055128.1	O95807	TM50A_HUMAN	transmembrane protein 50A	2						endoplasmic reticulum|integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;3.47e-27)|Colorectal(126;1.1e-08)|COAD - Colon adenocarcinoma(152;7.48e-07)|STAD - Stomach adenocarcinoma(196;0.00035)|BRCA - Breast invasive adenocarcinoma(304;0.00047)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|GBM - Glioblastoma multiforme(114;0.00106)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.204)		AAAAAAATGTCTGGATTTCTA	0.368000													7	73					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197208454	197208454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197208454C>T	ENST00000260983.2	-	3	509	c.327G>A	c.(325-327)aaG>aaA	p.K109K	HECW2_ENST00000409111.1_5'UTR	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	109					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CACCCCTGTTCTTAGAATCCC	0.383000													70	191					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84075595	84075595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84075595G>A	ENST00000299709.3	-	1	167	c.168C>T	c.(166-168)gtC>gtT	p.V56V		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	56					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						GGAAGGCAGGGACCACTCCGC	0.622000													52	111					0	0	1	0	0
RRP8	23378	broad.mit.edu	37	11	6624662	6624662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6624662G>A	ENST00000254605.6	-	1	188	c.71C>T	c.(70-72)cCt>cTt	p.P24L	RRP8_ENST00000534343.1_Missense_Mutation_p.P24L	NM_015324.3	NP_056139.1	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase, homolog (yeast)	24					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)	13						CGCAGGCGGAGGTCGTGAGAT	0.667000													4	11					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168265363	168265363	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:168265363C>T	ENST00000366806.2	+	2	380	c.238C>T	c.(238-240)Cga>Tga	p.R80*	MLLT4_ENST00000447894.2_Nonsense_Mutation_p.R80*|MLLT4_ENST00000351017.4_Nonsense_Mutation_p.R80*|MLLT4_ENST00000392108.3_Nonsense_Mutation_p.R80*|MLLT4_ENST00000392112.1_Nonsense_Mutation_p.R80*|MLLT4_ENST00000400822.3_Nonsense_Mutation_p.R80*|MLLT4_ENST00000344191.4_Nonsense_Mutation_p.R80*			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	80	Ras-associating 1.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GGAGAAATTTCGACCTGATAT	0.453000			T	MLL	AL								100	114					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63487353	63487353	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63487353C>T	ENST00000377819.5	+	3	1533	c.1379C>T	c.(1378-1380)tCt>tTt	p.S460F	RTN3_ENST00000354497.4_Intron|RTN3_ENST00000537981.1_Intron|RTN3_ENST00000356000.3_Intron|RTN3_ENST00000540798.1_Missense_Mutation_p.S348F|RTN3_ENST00000339997.4_Missense_Mutation_p.S441F|RTN3_ENST00000341307.2_Intron	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	460					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						AAATGTGACTCTTTGGGTTCT	0.448000													37	89					0	0	1	0	0
ADPRH	141	broad.mit.edu	37	3	119305142	119305142	+	Silent	SNP	G	G	A	rs142760415	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119305142G>A	ENST00000478399.1	+	3	1714	c.309G>A	c.(307-309)tcG>tcA	p.S103S	ADPRH_ENST00000471850.1_3'UTR|ADPRH_ENST00000465513.1_Silent_p.S103S|ADPRH_ENST00000478927.1_Silent_p.S103S|ADPRH_ENST00000357003.3_Silent_p.S103S			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	103					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		GTGGTGCCTCGGTGCACAACG	0.567000													21	249					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28121693	28121693	+	Silent	SNP	C	C	T	rs62638669	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28121693C>T	ENST00000330236.6	+	6	1819	c.1635C>T	c.(1633-1635)ccC>ccT	p.P545P	ZKSCAN8_ENST00000457389.2_Silent_p.P545P	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		GGGAGAAGCCCTACCAATGTA	0.423000													17	103					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73681055	73681055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73681055G>A	ENST00000339764.1	+	8	1598	c.847G>A	c.(847-849)Gac>Aac	p.D283N	RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000543947.1_Missense_Mutation_p.D108N|DNAJB13_ENST00000537753.1_Missense_Mutation_p.D108N	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	283					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					ATTGCCGGAGGACCCCACTAA	0.552000													67	144					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6174883	6174883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6174883G>A	ENST00000264870.3	-	12	1942	c.1677C>T	c.(1675-1677)acC>acT	p.T559T		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	559					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CGGTGTAGAAGGTGATGTTGG	0.502000													20	151					0	0	1	0	0
KRT36	8689	broad.mit.edu	37	17	39642774	39642774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39642774G>A	ENST00000393986.2	-	8	1320	c.1108C>T	c.(1108-1110)Cct>Tct	p.P370S	KRT36_ENST00000328119.6_Missense_Mutation_p.P420S			O76013	KRT36_HUMAN	keratin 36	420	Coil 2.|Rod.					intermediate filament	protein binding|structural constituent of epidermis			breast(2)|cervix(1)|kidney(2)|large_intestine(3)|lung(8)|skin(1)	17		Breast(137;0.000286)				GGGACAGAAGGAACTCTAATA	0.597000													8	9					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313535	54313535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54313535C>T	ENST00000324134.6	-	3	1546	c.1378G>A	c.(1378-1380)Ggg>Agg	p.G460R	NLRP12_ENST00000391772.1_Missense_Mutation_p.G460R|NLRP12_ENST00000535162.1_Missense_Mutation_p.G460R|NLRP12_ENST00000391773.1_Missense_Mutation_p.G460R|NLRP12_ENST00000354278.3_Missense_Mutation_p.G460R|NLRP12_ENST00000391775.3_Missense_Mutation_p.G460R|NLRP12_ENST00000351894.4_Missense_Mutation_p.G460R|NLRP12_ENST00000345770.5_Missense_Mutation_p.G460R	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	460	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GAGCACAACCCTCTCTGGTTG	0.617000													38	79					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25150165	25150165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25150165G>A	ENST00000332271.5	-	8	1209	c.793C>T	c.(793-795)Ctt>Ttt	p.L265F	PIWIL3_ENST00000533313.1_Missense_Mutation_p.L156F|PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.L156F	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	265					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						ACATAACCAAGCCAGATTTCC	0.403000													15	65					0	0	1	0	0
CPLX3	594855	broad.mit.edu	37	15	75122494	75122494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75122494C>T	ENST00000395018.4	+	3	433	c.276C>T	c.(274-276)atC>atT	p.I92I	RP11-414J4.2_ENST00000564823.1_RNA	NM_001030005.2	NP_001025176.1	Q8WVH0	CPLX3_HUMAN	complexin 3	92						cell junction|synapse	syntaxin binding			large_intestine(2)|lung(2)	4						AGAGCCAGATCCAGATGGCAG	0.612000													17	66					0	0	1	0	0
IL17REL	400935	broad.mit.edu	37	22	50436142	50436142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50436142C>T	ENST00000389983.2	-	12	1113	c.849G>A	c.(847-849)cgG>cgA	p.R283R	IL17REL_ENST00000341280.5_Silent_p.R283R	NM_001001694.2	NP_001001694.2	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	283										endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CGAAAGGGCACCGCACCCAGG	0.587000													15	58					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398393	89398393	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89398393G>A	ENST00000439576.2	+	12	2951	c.2577G>A	c.(2575-2577)gaG>gaA	p.E859E	ACAN_ENST00000559004.1_Silent_p.E859E|ACAN_ENST00000561243.1_Silent_p.E859E|ACAN_ENST00000352105.7_Silent_p.E859E	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	859					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCTCTGGGGAGGAATCTGGGG	0.607000													10	47					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237349719	237349719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237349719C>T	ENST00000409907.3	-	7	1249	c.975G>A	c.(973-975)ggG>ggA	p.G325G	IQCA1_ENST00000465621.1_5'UTR|IQCA1_ENST00000431676.2_Silent_p.G325G|IQCA1_ENST00000309507.5_Silent_p.G321G			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	325							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						TAATAGCTGACCCTCCTTCTT	0.313000													2	1					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4730287	4730287	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4730287C>T	ENST00000354582.6	+	31	4161	c.3811C>T	c.(3811-3813)Ctg>Ttg	p.L1271L	ITPR1_ENST00000302640.8_Silent_p.L1256L|ITPR1_ENST00000456211.2_Silent_p.L1247L|ITPR1_ENST00000423119.2_Silent_p.L1262L|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Silent_p.L1262L|ITPR1_ENST00000443694.2_Silent_p.L1256L			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1271					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ACACATAAACCTGTTTCTCAA	0.458000													5	59					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307510	140307510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140307510C>T	ENST00000253807.2	+	1	1033	c.1033C>T	c.(1033-1035)Ctt>Ttt	p.L345F	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.L345F|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCCTGACTCTTTCGAACCC	0.527000													48	115					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971770	96971770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96971770C>T	ENST00000341686.3	+	6	1016	c.891C>T	c.(889-891)ttC>ttT	p.F297F	C10orf129_ENST00000430183.1_Silent_p.F142F|C10orf129_ENST00000394005.3_Silent_p.F297F	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	297					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		TGCCAACCTTCTGCCCTGAGA	0.502000													19	51					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136661588	136661588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136661588G>A	ENST00000371851.1	-	10	1305	c.980C>T	c.(979-981)cCc>cTc	p.P327L	VAV2_ENST00000406606.3_Missense_Mutation_p.P327L|VAV2_ENST00000371850.3_Missense_Mutation_p.P332L			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	332	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CCTCTGCATGGGGACCACCAG	0.612000													7	27					0	0	1	0	0
OR5K3	403277	broad.mit.edu	37	3	98109721	98109721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98109721C>T	ENST00000383695.1	+	1	212	c.212C>T	c.(211-213)tCc>tTc	p.S71F	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005516.1	NP_001005516.1	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K, member 3	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|prostate(1)|skin(1)|urinary_tract(1)	27						CTGATGGATTCCTGCTGTTCC	0.393000													106	289					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44815231	44815231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44815231G>A	ENST00000372262.3	-	9	2059	c.1659C>T	c.(1657-1659)atC>atT	p.I553I	CDH22_ENST00000537909.1_Silent_p.I553I	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	553	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GCTCACCTTGGATGTCAAGCA	0.597000													21	63					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967584	41967584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41967584G>A	ENST00000298919.7	+	10	2611	c.2223G>A	c.(2221-2223)aaG>aaA	p.K741K	PDZRN4_ENST00000402685.2_Silent_p.K1001K|PDZRN4_ENST00000539469.2_Silent_p.K743K			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	1001							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AGAGAAACAAGAAAATTTTGG	0.458000													10	36					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54530490	54530490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:54530490G>A	ENST00000373968.3	-	2	308	c.244C>T	c.(244-246)Cca>Tca	p.P82S	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	82	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						GAAGGCCCTGGATTTCCTGGA	0.547000													28	132					0	0	1	0	0
CLEC6A	93978	broad.mit.edu	37	12	8612237	8612237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8612237G>A	ENST00000382073.3	+	3	352	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K		NM_001007033.1	NP_001007034.1	Q6EIG7	CLC6A_HUMAN	C-type lectin domain family 6, member A	56					defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)|large_intestine(2)|lung(7)	10	Lung SC(5;0.184)					AAGGCTGTCTGAACTACACTC	0.363000													20	148					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131519878	131519878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131519878C>T	ENST00000423981.1	+	2	343	c.233C>T	c.(232-234)cCc>cTc	p.P78L	AMER3_ENST00000321420.4_Missense_Mutation_p.P78L	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		AAAGGGGGACCCGCAGCCCTC	0.652000													7	10					0	0	1	0	0
MTL5	9633	broad.mit.edu	37	11	68478463	68478463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68478463C>T	ENST00000255087.5	-	9	1396	c.1213G>A	c.(1213-1215)Gaa>Aaa	p.E405K		NM_004923.3	NP_004914.2	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific (tesmin)	405	CXC 2.				cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	15	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TCTGGGCTTTCTTCATAATTT	0.393000													20	51					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96731038	96731038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96731038C>T	ENST00000216629.6	+	3	1625	c.1019C>T	c.(1018-1020)tCa>tTa	p.S340L	BDKRB1_ENST00000553356.1_Intron|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	340					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		CCAATATCTTCATCCCATAGG	0.388000													65	162					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149521605	149521605	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149521605C>T	ENST00000378016.2	+	0	13684							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCAACTGGCCTCTCCCCCAC	0.711000													16	40					0	0	1	0	0
HMG20B	10362	broad.mit.edu	37	19	3578095	3578095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3578095C>T	ENST00000333651.6	+	9	1000	c.925C>T	c.(925-927)Ctg>Ttg	p.L309L		NM_006339.2	NP_006330.2	Q9P0W2	HM20B_HUMAN	high mobility group 20B	309					blood coagulation|cell cycle|chromatin modification	chromosome|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGGAAATCCTGGCCCAGGT	0.706000													6	23					0	0	1	0	0
ADCY3	109	broad.mit.edu	37	2	25141452	25141452	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:25141452G>A	ENST00000260600.5	-	1	1256	c.405C>T	c.(403-405)acC>acT	p.T135T		NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	135					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GCACTCTGCGGGTGACCCGGT	0.627000													7	92					0	0	1	0	0
OR8K5	219453	broad.mit.edu	37	11	55927463	55927463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55927463C>T	ENST00000313447.1	-	1	330	c.331G>A	c.(331-333)Gaa>Aaa	p.E111K		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATGAAAAATTCACTGATAATG	0.418000													12	117					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25593852	25593852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:25593852C>T	ENST00000269141.3	-	3	617	c.194G>A	c.(193-195)gGa>gAa	p.G65E	CDH2_ENST00000399380.3_Missense_Mutation_p.G34E	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	65					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TTTTCTTTTTCCATTGCAGTT	0.358000													15	53					0	0	1	0	0
IGFL1	374918	broad.mit.edu	37	19	46733686	46733686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46733686G>A	ENST00000437936.1	+	3	258	c.235G>A	c.(235-237)Gag>Aag	p.E79K		NM_198541.1	NP_940943.1	Q6UW32	IGFL1_HUMAN	IGF-like family member 1	79						extracellular space	protein binding			lung(5)	5		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.00242)|all cancers(93;0.0132)|GBM - Glioblastoma multiforme(486;0.0294)|Epithelial(262;0.201)		AGTCTGCTTTGAGCAGTGCTG	0.572000													32	125					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307697	46307697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46307697G>A	ENST00000221538.3	-	3	1608	c.1466C>T	c.(1465-1467)tCg>tTg	p.S489L	RSPH6A_ENST00000597055.1_Missense_Mutation_p.S489L|RSPH6A_ENST00000600188.1_Missense_Mutation_p.S225L	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	489						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						CGTGGCGGCCGAGATGCGGGC	0.642000													23	52					0	0	1	0	0
MRPL21	219927	broad.mit.edu	37	11	68664142	68664142	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68664142G>A	ENST00000362034.2	-	4	246	c.237C>T	c.(235-237)gtC>gtT	p.V79V	MRPL21_ENST00000567045.1_5'UTR|MRPL21_ENST00000450904.2_5'UTR	NM_181514.1|NM_181515.1	NP_852615.1|NP_852616.1	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21	79					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome			large_intestine(1)|lung(6)|prostate(1)	8			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCTTCTTCACGACCTCTGCAG	0.632000													27	100					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154876048	154876048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:154876048C>T	ENST00000287907.2	+	2	1501	c.925C>T	c.(925-927)Ccc>Tcc	p.P309S	HTR5A_ENST00000486819.1_3'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	309						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GCTCATCAGTCCCCTCTGCTC	0.572000													46	143					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274047	10274047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10274047C>T	ENST00000396573.2	-	3	531	c.222G>A	c.(220-222)atG>atA	p.M74I	GRIN2A_ENST00000404927.2_Missense_Mutation_p.M74I|GRIN2A_ENST00000562109.1_Missense_Mutation_p.M74I|GRIN2A_ENST00000330684.3_Missense_Mutation_p.M74I|GRIN2A_ENST00000396575.2_Missense_Mutation_p.M74I	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	74					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGGTGCGGTTCATCAGCAGAG	0.662000													45	91					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46328540	46328540	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46328540G>A	ENST00000245934.7	-	18	2623	c.2379C>T	c.(2377-2379)ctC>ctT	p.L793L		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	793					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GGGCCAGGTAGAGGTACAGAC	0.612000													12	44					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999572	46999572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46999572C>T	ENST00000374314.4	+	1	1647	c.692C>T	c.(691-693)cCa>cTa	p.P231L	GPRIN2_ENST00000374317.1_Missense_Mutation_p.P231L			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	231										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GCTCTGCCCCCAGCTGCTCTA	0.627000													15	38					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107773266	107773266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:107773266C>T	ENST00000311955.3	-	2	1199	c.1145G>A	c.(1144-1146)tGa>tAa	p.*382*		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	0					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			TTTGAAGGTTCACTTGAGTAG	0.413000													74	161					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20848472	20848472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20848472G>A	ENST00000262715.5	-	34	4965	c.4925C>T	c.(4924-4926)tCg>tTg	p.S1642L	TEP1_ENST00000556935.1_Missense_Mutation_p.S1534L|TEP1_ENST00000545983.1_5'UTR	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1642					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGAGAGCAGCGAGGCTTGGTG	0.587000													68	154					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81592522	81592522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81592522C>T	ENST00000394660.2	+	14	3215	c.2855C>T	c.(2854-2856)tCt>tTt	p.S952F	IL16_ENST00000302987.4_Missense_Mutation_p.S952F|IL16_ENST00000394652.2_Missense_Mutation_p.S251F	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	952					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GCTGAGGAATCTCAAGGCCCA	0.617000													50	46					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409275	105409275	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105409275G>A	ENST00000333244.5	-	7	12632	c.12513C>T	c.(12511-12513)tcC>tcT	p.S4171S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4171						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCCTGCATGGAGGGGAGGC	0.632000													106	251					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7287995	7287995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7287995G>A	ENST00000537408.1	+	3	1030	c.492G>A	c.(490-492)gcG>gcA	p.A164A	CLSTN3_ENST00000266546.6_Silent_p.A152A			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	152	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						TGTATCGTGCGGCTGTGACAG	0.567000													25	56					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170239104	170239104	+	Missense_Mutation	SNP	G	G	A	rs147911240		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:170239104G>A	ENST00000518525.1	+	11	1629	c.1165G>A	c.(1165-1167)Gac>Aac	p.D389N	GABRP_ENST00000519385.1_3'UTR|GABRP_ENST00000265294.4_Missense_Mutation_p.D389N			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	389						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAAAACCAGCGACAAGTTCAA	0.408000													42	85					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639996	7639996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7639996G>A	ENST00000359156.4	-	8	2211	c.2009C>T	c.(2008-2010)tCa>tTa	p.S670L	CD163_ENST00000432237.2_Missense_Mutation_p.S670L|CD163_ENST00000396620.3_Missense_Mutation_p.S703L|CD163_ENST00000541972.1_Missense_Mutation_p.S658L	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	670	SRCR 6.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AGGACATAATGAAGCACCTAG	0.483000													25	45					0	0	1	0	0
CDC34	997	broad.mit.edu	37	19	532077	532077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:532077C>T	ENST00000215574.4	+	1	364	c.146C>T	c.(145-147)cCc>cTc	p.P49L		NM_004359.1	NP_004350.1	P49427	UB2R1_HUMAN	cell division cycle 34	49					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(1)	2		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCGGGCCCCCCAACACCTAC	0.687000													3	12					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122833219	122833219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122833219C>T	ENST00000264811.5	-	4	1570	c.1152G>A	c.(1150-1152)atG>atA	p.M384I	TRPC3_ENST00000513531.1_Missense_Mutation_p.M329I|TRPC3_ENST00000379645.3_Missense_Mutation_p.M457I	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	372					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CTACAAACTTCATAAAAGGGC	0.443000													21	43					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6309836	6309836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6309836G>A	ENST00000301452.4	-	4	437	c.360C>T	c.(358-360)ttC>ttT	p.F120F		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	120						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						CCAGGCGGATGAACTGGGACC	0.617000													15	38					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142572322	142572322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142572322G>A	ENST00000359396.3	-	11	1619	c.1374C>T	c.(1372-1374)ctC>ctT	p.L458L		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	458					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					AGCCCAGCACGAGTGCAAAGG	0.592000													22	44					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35824855	35824855	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35824855C>T	ENST00000314607.6	+	3	495	c.415C>T	c.(415-417)Cct>Tct	p.P139S	ZMYM4_ENST00000373297.2_Missense_Mutation_p.P139S|ZMYM4-AS1_ENST00000432683.1_RNA	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	139					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAAGACTTTCCTAAACAATT	0.308000													11	40					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154412272	154412272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:154412272C>T	ENST00000414028.2	+	3	879	c.829C>T	c.(829-831)Ctt>Ttt	p.L277F	OPRM1_ENST00000419506.2_Missense_Mutation_p.L277F|OPRM1_ENST00000452687.2_Missense_Mutation_p.L277F|OPRM1_ENST00000435918.2_Missense_Mutation_p.L277F|OPRM1_ENST00000434900.2_Missense_Mutation_p.L370F|OPRM1_ENST00000428397.2_Missense_Mutation_p.L277F|OPRM1_ENST00000520708.1_Missense_Mutation_p.L177F|OPRM1_ENST00000229768.5_Missense_Mutation_p.L277F|OPRM1_ENST00000522236.1_Missense_Mutation_p.L177F|OPRM1_ENST00000518759.1_Missense_Mutation_p.L196F|OPRM1_ENST00000330432.7_Missense_Mutation_p.L277F|OPRM1_ENST00000524163.1_Missense_Mutation_p.L277F|OPRM1_ENST00000360422.4_Missense_Mutation_p.L277F|OPRM1_ENST00000337049.4_Missense_Mutation_p.L277F|OPRM1_ENST00000522555.1_Missense_Mutation_p.L177F	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	277					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	GGACAGGAATCTTCGAAGGAT	0.488000													36	45					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48389216	48389216	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48389216G>A	ENST00000224600.4	-	1	1775	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	554	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	ACTGCATAAGGAAGGCGAACT	0.672000													27	49					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26228908	26228908	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26228908C>T	ENST00000335473.7	+	16	3254	c.3004C>T	c.(3004-3006)Ctc>Ttc	p.L1002F	MYO18B_ENST00000536101.1_Missense_Mutation_p.L1002F|MYO18B_ENST00000407587.2_Missense_Mutation_p.L1002F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1002	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCAGTTTGACCTCCCGGACCC	0.507000													11	88					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27220706	27220706	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:27220706G>A	ENST00000230582.3	+	9	1143	c.1128G>A	c.(1126-1128)caG>caA	p.Q376Q	PRSS16_ENST00000377456.2_Intron|PRSS16_ENST00000421826.2_Silent_p.Q119Q	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	376					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GGTTGTATCAGACATGTACCG	0.502000													58	125					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43226909	43226909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43226909C>T	ENST00000259750.4	+	11	1233	c.1150C>T	c.(1150-1152)Ccc>Tcc	p.P384S	TTBK1_ENST00000304139.5_Missense_Mutation_p.P333S	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	384						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGGGCTGGGCCCCAGTCCCCA	0.627000													20	75					0	0	1	0	0
WWC1	23286	broad.mit.edu	37	5	167882460	167882460	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167882460C>T	ENST00000265293.4	+	19	3260	c.2758C>T	c.(2758-2760)Cga>Tga	p.R920*	WWC1_ENST00000521089.1_Nonsense_Mutation_p.R920*|WWC1_ENST00000522140.1_3'UTR	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	920	Interaction with histone H3.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		GCCATTTCTTCGAGGGAGCAC	0.642000													31	151					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61463546	61463546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61463546G>A	ENST00000398019.2	+	5	708	c.383G>A	c.(382-384)cGa>cAa	p.R128Q	SERPINB7_ENST00000336429.2_Missense_Mutation_p.R128Q|SERPINB7_ENST00000546027.1_Missense_Mutation_p.R128Q|SERPINB7_ENST00000540675.1_Missense_Mutation_p.R111Q	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	128					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				AAAGTGGAGCGAGTTGACTTT	0.328000													11	62					0	0	1	0	0
CDKL4	344387	broad.mit.edu	37	2	39406354	39406354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:39406354C>T	ENST00000378803.1	-	8	900	c.901G>A	c.(901-903)Gaa>Aaa	p.E301K	CDKL4_ENST00000395035.3_Missense_Mutation_p.E301K	NM_001009565.1	NP_001009565.1	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	301						cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)|large_intestine(2)|liver(1)|lung(7)|ovary(1)	12		all_hematologic(82;0.248)				TTTCTTCCTTCATTACGTGCT	0.378000													36	141					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6749668	6749668	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6749668C>T	ENST00000229243.2	-	7	1191	c.1098G>A	c.(1096-1098)cgG>cgA	p.R366R	ACRBP_ENST00000414226.2_Silent_p.R333R|ACRBP_ENST00000542357.1_5'UTR	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	366						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						ACATGTGTCGCCGCCCAAGGC	0.637000													4	17					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139155304	139155304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139155304C>T	ENST00000395297.1	-	16	3759	c.3589G>A	c.(3589-3591)Gaa>Aaa	p.E1197K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1197										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGAATGATTTCATCCAATAAC	0.458000										HNSCC(54;0.14)			6	60					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83764144	83764144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83764144G>A	ENST00000265362.3	-	2	550	c.236C>T	c.(235-237)tCa>tTa	p.S79L	SEMA3A_ENST00000436949.1_Missense_Mutation_p.S79L	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	79	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CAGGTCGAATGAAAATATGTG	0.358000													22	63					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10348598	10348598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10348598C>T	ENST00000255381.2	-	36	5361	c.5251G>A	c.(5251-5253)Gaa>Aaa	p.E1751K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1751					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTGCGGGCTTCCTGGACGATG	0.468000													45	109					0	0	1	0	0
NEK1	4750	broad.mit.edu	37	4	170327882	170327882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:170327882G>A	ENST00000439128.2	-	30	3795	c.3155C>T	c.(3154-3156)tCa>tTa	p.S1052L	NEK1_ENST00000511633.1_Missense_Mutation_p.S1036L|NEK1_ENST00000510533.1_Missense_Mutation_p.S1008L|NEK1_ENST00000507142.1_Missense_Mutation_p.S1080L|NEK1_ENST00000512193.1_Missense_Mutation_p.S983L	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1052					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		ATCTGGAAGTGAACATGTCCT	0.313000													23	41					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160789114	160789114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160789114C>T	ENST00000263285.5	+	7	1478	c.1448C>T	c.(1447-1449)tCa>tTa	p.S483L	LY9_ENST00000341032.4_Missense_Mutation_p.S393L|LY9_ENST00000368035.1_Missense_Mutation_p.S135L|LY9_ENST00000368040.1_Missense_Mutation_p.S135L|LY9_ENST00000368041.2_Missense_Mutation_p.S353L	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	483					cell adhesion|immunoglobulin mediated immune response	integral to membrane		p.S483*(1)		autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTCTCAGGTTCAGTCCCAGCC	0.493000													41	89					0	0	1	0	0
AKR1C1	1645	broad.mit.edu	37	10	5011070	5011070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5011070C>T	ENST00000380872.4	+	5	696	c.504C>T	c.(502-504)ttC>ttT	p.F168F	AKR1C1_ENST00000434459.2_Silent_p.F168F|AKR1C1_ENST00000380859.1_Silent_p.F170F|AKR1C1_ENST00000477661.1_3'UTR	NM_001353.5	NP_001344.2			aldo-keto reductase family 1, member C1											breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(2)|ovary(3)|prostate(1)	13						TGTCCAACTTCAACCGCAGGC	0.517000													42	80					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51759245	51759245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51759245C>T	ENST00000543196.2	-	4	988	c.783G>A	c.(781-783)caG>caA	p.Q261Q	GALNT6_ENST00000356317.3_Silent_p.Q261Q			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	261	Catalytic subdomain A.				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						GCACCTCCGCCTGTGCCACGC	0.672000													22	52					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364297	5364297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5364297G>A	ENST00000300773.2	-	1	512	c.458C>T	c.(457-459)tCc>tTc	p.S153F	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGAACAACGGATACAAATCC	0.443000													24	77					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79375891	79375891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79375891G>A	ENST00000350881.2	+	20	2865	c.2675G>A	c.(2674-2676)gGc>gAc	p.G892D	THBS4_ENST00000504720.1_3'UTR|THBS4_ENST00000511733.1_Missense_Mutation_p.G801D|CTD-2201I18.1_ENST00000514042.1_RNA|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	892	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CCCCAGGTGGGCTACATCAGG	0.557000													3	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179599464	179599464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179599464C>T	ENST00000589042.1	-	51	15411	c.15187G>A	c.(15187-15189)Gat>Aat	p.D5063N	TTN_ENST00000342992.6_Missense_Mutation_p.D3819N|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.D4746N|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4746	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCAGCTATCACTGCCGACG	0.353000													40	146					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566641	5566641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5566641G>A	ENST00000322653.4	-	1	138	c.113C>T	c.(112-114)cCc>cTc	p.P38L	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATACAGAAGGGAATTCCAAT	0.458000													29	58					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21425035	21425035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21425035G>A	ENST00000313654.9	+	30	3907	c.3666G>A	c.(3664-3666)atG>atA	p.M1222I	LAMA3_ENST00000399516.3_Missense_Mutation_p.M1222I	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1222	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAAATCCATGGACAAGTCAC	0.423000													15	38					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101739389	101739389	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101739389C>T	ENST00000261637.4	+	37	4837	c.4663C>T	c.(4663-4665)Caa>Taa	p.Q1555*		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1555					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						CTTTCCAAACCAACTGGAATT	0.338000													22	64					0	0	1	0	0
MMP19	4327	broad.mit.edu	37	12	56236591	56236591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56236591C>T	ENST00000322569.4	-	1	115	c.24G>A	c.(22-24)ctG>ctA	p.L8L	MMP19_ENST00000548629.1_Silent_p.L8L|MMP19_ENST00000547487.1_5'UTR|MMP19_ENST00000409200.3_Silent_p.L8L	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	8					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						GTAGGAAGCCCAGCCACAGCT	0.637000													3	10					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21255406	21255406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21255406G>A	ENST00000233242.1	-	10	1299	c.1172C>T	c.(1171-1173)tCc>tTc	p.S391F	APOB_ENST00000399256.4_Missense_Mutation_p.S391F	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	391	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATGTGAGTGGAGCACTGAGG	0.527000													18	48					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178802677	178802677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:178802677C>T	ENST00000367635.3	+	8	937	c.599C>T	c.(598-600)cCc>cTc	p.P200L	RALGPS2_ENST00000367634.2_Missense_Mutation_p.P200L|RALGPS2_ENST00000324778.4_Missense_Mutation_p.P165L	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	200	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						CCTTGCATTCCCTATTTAGGT	0.289000													27	78					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17698394	17698394	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:17698394C>T	ENST00000399080.2	-	1	1312	c.1289G>A	c.(1288-1290)tGg>tAg	p.W430*		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	430										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TAGCCAATTCCATTTTTCTTC	0.289000													10	21					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102051118	102051118	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102051118C>T	ENST00000318222.3	-	12	2329	c.1947G>A	c.(1945-1947)ggG>ggA	p.G649G	PKD2L1_ENST00000338519.3_Silent_p.G574G|PKD2L1_ENST00000353274.3_Silent_p.G649G	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	649					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		GAATACGATTCCCATCTCTGT	0.502000													48	67					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18170872	18170872	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18170872C>T	ENST00000600835.1	-	17	2118	c.1815G>A	c.(1813-1815)gtG>gtA	p.V605V	IL12RB1_ENST00000593993.1_Silent_p.V605V|IL12RB1_ENST00000430026.2_Silent_p.V605V			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	605					cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCTGGAAGTCCACTGGGTTGA	0.592000													3	18					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51217155	51217155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51217155C>T	ENST00000293441.1	-	5	710	c.692G>A	c.(691-693)cGa>cAa	p.R231Q	SHANK1_ENST00000359082.3_Missense_Mutation_p.R231Q|SHANK1_ENST00000391814.1_Missense_Mutation_p.R231Q	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	231					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCACAGGGTTCGAATCACCTC	0.647000													17	39					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46243472	46243472	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:46243472C>T	ENST00000334344.6	+	14	1997	c.1825C>T	c.(1825-1827)Cag>Tag	p.Q609*	ARID2_ENST00000444670.1_Nonsense_Mutation_p.Q219*|ARID2_ENST00000422737.1_Nonsense_Mutation_p.Q460*|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	609					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACTTCCCATTCAGATGTACTA	0.438000			"""N, S, F"""		hepatocellular carcinoma								73	190					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108382640	108382640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108382640G>A	ENST00000265843.4	-	6	3704	c.3594C>T	c.(3592-3594)tcC>tcT	p.S1198S	EXPH5_ENST00000428840.1_Silent_p.S1122S|EXPH5_ENST00000443411.1_Silent_p.S1010S|EXPH5_ENST00000525344.1_Silent_p.S1191S	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1198					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CACTTCTCCTGGAGGCAGCCA	0.378000													59	139					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151093031	151093031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151093031C>T	ENST00000370335.1	+	3	1162	c.895C>T	c.(895-897)Cgc>Tgc	p.R299C	MAGEA4_ENST00000276344.2_Missense_Mutation_p.R299C|MAGEA4_ENST00000393921.1_Missense_Mutation_p.R299C|MAGEA4_ENST00000370340.3_Missense_Mutation_p.R299C|MAGEA4_ENST00000370337.4_Missense_Mutation_p.R299C|MAGEA4_ENST00000360243.2_Missense_Mutation_p.R299C|MAGEA4_ENST00000393920.1_Missense_Mutation_p.R299C			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	299	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGCAAGAGTTCGCATTGCCTA	0.567000													67	50					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64527218	64527218	+	Missense_Mutation	SNP	C	C	T	rs141560382	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64527218C>T	ENST00000498707.1	-	34	5618	c.5276G>A	c.(5275-5277)aGa>aAa	p.R1759K	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.R1731K	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1759	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		AAGCTTTCCTCTAATCATCAG	0.398000													54	105					0	0	1	0	0
TPTE2P2	644623	broad.mit.edu	37	13	52854008	52854008	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52854008C>T	ENST00000451298.1	-	0	529				RP11-64P12.8_ENST00000606031.1_RNA																							GACTGGCCTCCCGAAGATGGA	0.303000													3	18					0	0	1	0	0
OR51D1	390038	broad.mit.edu	37	11	4661207	4661207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4661207C>T	ENST00000357605.2	+	1	263	c.187C>T	c.(187-189)Cgt>Tgt	p.R63C		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTCATCATTCGTGTGGAGAG	0.542000													12	72					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65262303	65262303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65262303C>T	ENST00000389722.3	-	11	1449	c.1396G>A	c.(1396-1398)Gcc>Acc	p.A466T	SPTB_ENST00000389720.3_Missense_Mutation_p.A466T|SPTB_ENST00000389721.5_Missense_Mutation_p.A466T|SPTB_ENST00000556626.1_Missense_Mutation_p.A466T|SPTB_ENST00000542895.1_Missense_Mutation_p.A466T	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	466					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GTCTCGATGGCCTCATGCTTC	0.597000													10	69					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394039	154394039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154394039C>T	ENST00000435029.4	+	1	780	c.620C>T	c.(619-621)tCc>tTc	p.S207F		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	207	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GCTATGAACTCCCAGTCGTCC	0.468000													17	146					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151672380	151672380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:151672380G>A	ENST00000402676.2	+	4	3094	c.2854G>A	c.(2854-2856)Gaa>Aaa	p.E952K	AKAP12_ENST00000253332.1_Missense_Mutation_p.E952K|AKAP12_ENST00000354675.6_Missense_Mutation_p.E854K|AKAP12_ENST00000359755.5_Missense_Mutation_p.E847K	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	952					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CACGGTTACTGAACCTCTGCC	0.532000													25	72					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098882	11098882	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11098882C>T	ENST00000470054.1	-	0	43									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tctcctggtcctctaagccgg	0.607000													4	27					0	0	1	0	0
WNT6	7475	broad.mit.edu	37	2	219736279	219736279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219736279C>T	ENST00000233948.3	+	3	591	c.374C>T	c.(373-375)tCt>tTt	p.S125F	WNT6_ENST00000486233.1_3'UTR	NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	125					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGGCCTGTTCTATGGGCGAG	0.741000													9	21					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43815292	43815292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43815292G>A	ENST00000382031.1	+	5	2366	c.2335G>A	c.(2335-2337)Gag>Aag	p.E779K	MAP1A_ENST00000300231.5_Missense_Mutation_p.E541K|MAP1A_ENST00000399453.1_Missense_Mutation_p.E541K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	541						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GATGAAGCGTGAGGAGAGGGC	0.552000													33	117					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1103314	1103314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1103314C>T	ENST00000441003.2	+	46	8091	c.8064C>T	c.(8062-8064)atC>atT	p.I2688I		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	5050						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GCATTTGCATCCCGGTGAGTT	0.602000													5	56					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18331127	18331127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18331127G>A	ENST00000355502.3	-	11	1582	c.711C>T	c.(709-711)ttC>ttT	p.F237F	PDE4C_ENST00000539010.1_Silent_p.F6F|PDE4C_ENST00000594617.2_Silent_p.F237F|PDE4C_ENST00000262805.11_Silent_p.F205F|PDE4C_ENST00000594465.2_Silent_p.F237F|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000447275.2_Silent_p.F131F			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	237					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GGATCCGCTTGAACTGGGGCG	0.622000													39	101					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46976894	46976894	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46976894G>A	ENST00000371253.2	-	11	2492	c.2277C>T	c.(2275-2277)ttC>ttT	p.F759F	GPR110_ENST00000283297.5_Silent_p.F562F|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	759					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						GCACCACAACGAAGTTCACAG	0.527000													30	55					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77776193	77776193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77776193G>A	ENST00000521891.2	+	11	10691	c.10243G>A	c.(10243-10245)Gaa>Aaa	p.E3415K	ZFHX4_ENST00000050961.6_Missense_Mutation_p.E3366K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E3370K|ZFHX4_ENST00000518282.1_Missense_Mutation_p.E3389K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3366						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTTTACTGATGAAGACGCCGC	0.418000										HNSCC(33;0.089)			3	20					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370122	240370122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240370122G>A	ENST00000319653.9	+	5	2240	c.2010G>A	c.(2008-2010)gaG>gaA	p.E670E		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	670					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGAAGTCTGAGGGACAGGCCA	0.423000													15	51					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84582010	84582010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84582010G>A	ENST00000286744.5	+	16	2091	c.1867G>A	c.(1867-1869)Gaa>Aaa	p.E623K	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.E623K	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	623	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGCCTCCTGGAAGCATGTGA	0.612000													18	50					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108682435	108682435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108682435G>A	ENST00000232603.5	-	27	2707	c.2625C>T	c.(2623-2625)gtC>gtT	p.V875V	MORC1_ENST00000483760.1_Silent_p.V854V	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	875					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTTCATATTGGACCATGTAAG	0.284000													9	48					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139874654	139874654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139874654G>A	ENST00000224167.2	+	5	645	c.570G>A	c.(568-570)agG>agA	p.R190R	PTGDS_ENST00000371625.3_Silent_p.R156R			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	156					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGACCCCCAGGGCTGAGTTAA	0.632000													13	39					0	0	1	0	0
TSPAN32	10077	broad.mit.edu	37	11	2334931	2334931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2334931G>A	ENST00000182290.4	+	5	539	c.402G>A	c.(400-402)gcG>gcA	p.A134A	TSPAN32_ENST00000381121.3_Silent_p.A134A|TSPAN32_ENST00000451520.2_Silent_p.A123A|TSPAN32_ENST00000483227.1_3'UTR	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	134					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		ATGAGCAGGCGATGAAAGGTA	0.662000													4	7					0	0	1	0	0
BEX5	340542	broad.mit.edu	37	X	101409099	101409099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:101409099C>T	ENST00000543160.1	-	3	440	c.139G>A	c.(139-141)Gga>Aga	p.G47R	BEX5_ENST00000333643.3_Missense_Mutation_p.G47R	NM_001159560.1	NP_001153032.1	Q5H9J7	BEX5_HUMAN	brain expressed, X-linked 5	47						cytoplasm				large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	4						ACATCCTCTCCAAAACCCGGG	0.517000													42	35					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218940349	218940349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:218940349G>A	ENST00000374155.3	+	8	1604	c.1194G>A	c.(1192-1194)caG>caA	p.Q398Q	RUFY4_ENST00000344321.7_Silent_p.Q378Q|RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000463872.1_3'UTR			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	378							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGGTCCTTCAGGGACACGCAA	0.617000													23	38					0	0	1	0	0
EXOC6	54536	broad.mit.edu	37	10	94653169	94653169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:94653169C>T	ENST00000371552.4	+	2	179	c.150C>T	c.(148-150)atC>atT	p.I50I	EXOC6_ENST00000443748.2_Silent_p.I55I|EXOC6_ENST00000260762.6_Silent_p.I55I|EXOC6_ENST00000371547.4_Silent_p.I71I|EXOC6_ENST00000371543.1_Silent_p.I55I	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	55					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				ATGCTTGTATCCGTAATCATG	0.338000													41	92					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167060669	167060669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167060669G>A	ENST00000375387.4	-	26	4913	c.4573C>T	c.(4573-4575)Ctt>Ttt	p.L1525F	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.L1513F|SCN9A_ENST00000409435.1_Missense_Mutation_p.L1524F|SCN9A_ENST00000303354.6_Missense_Mutation_p.L1525F			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1524						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AGACAGATAAGAACCATGATA	0.328000													24	48					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60643116	60643116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60643116G>A	ENST00000278853.5	+	12	1904	c.1904G>A	c.(1903-1905)aGc>aAc	p.S635N		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	635					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CTCTGGGAAAGCAACAGACAG	0.493000													14	34					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981915	7981915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7981915G>A	ENST00000328600.2	-	2	1405	c.1244C>T	c.(1243-1245)tCc>tTc	p.S415F		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	415	NACHT.						ATP binding	p.S415F(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCTGCTAGGGAGCACAGACT	0.547000													24	64					0	0	1	0	0
LINC00922	283867	broad.mit.edu	37	16	65345360	65345360	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:65345360G>A	ENST00000569736.1	-	0	775				RP11-256I9.3_ENST00000562656.1_lincRNA	NR_027755.1																						ATGCCTTCACGAATGTATGCC	0.468000													39	113					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133051061	133051061	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133051061C>T	ENST00000262283.5	-	11	1291	c.1192G>A	c.(1192-1194)Gac>Aac	p.D398N	OC90_ENST00000443356.2_Missense_Mutation_p.D202N|OC90_ENST00000254627.3_Missense_Mutation_p.D202N|OC90_ENST00000603859.1_Missense_Mutation_p.D202N			Q02509	OC90_HUMAN	otoconin 90	202	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GTTGTCAAGTCTTCCTTGATG	0.517000													8	21					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4702675	4702675	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4702675C>T	ENST00000302640.8	+	13	1460	c.1110C>T	c.(1108-1110)aaC>aaT	p.N370N	ITPR1_ENST00000456211.2_Silent_p.N370N|ITPR1_ENST00000443694.2_Silent_p.N370N|ITPR1_ENST00000357086.4_Silent_p.N385N|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000423119.2_Silent_p.N385N|ITPR1_ENST00000354582.6_Silent_p.N385N	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	385	MIR 4.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTGTTAGGAACTCTTATGTTC	0.368000													10	32					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121485642	121485642	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121485642G>A	ENST00000260197.7	+	41	5611	c.5482G>A	c.(5482-5484)Gat>Aat	p.D1828N	SORL1_ENST00000534286.1_Missense_Mutation_p.D738N|SORL1_ENST00000525532.1_Missense_Mutation_p.D772N|SORL1_ENST00000532694.1_Missense_Mutation_p.D674N|SORL1_ENST00000527934.1_Missense_Mutation_p.D443N	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1828	Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGACTTGGGGGATAGCCCTCT	0.512000													12	141					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121863	38121863	+	Silent	SNP	C	C	T	rs140427804		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38121863C>T	ENST00000406386.3	+	7	3555	c.3300C>T	c.(3298-3300)tcC>tcT	p.S1100S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1100					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.S1100S(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AGTGTCAGTCCCCCCAACACG	0.667000													69	177					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143100923	143100923	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:143100923C>T	ENST00000316549.6	-	13	1711	c.1503G>A	c.(1501-1503)gaG>gaA	p.E501E	SLC9A9-AS2_ENST00000490153.1_RNA	NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	501					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						AGGAGGGGTCCTCCTTCAGAT	0.443000													26	237					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43579608	43579608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43579608C>T	ENST00000452443.2	-	6	739	c.735G>A	c.(733-735)gaG>gaA	p.E245E		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	245					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TGGAGTAGTCCTCGCCCCAGT	0.602000													12	38					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84270630	84270630	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84270630C>T	ENST00000568181.1	-	2	582	c.462G>A	c.(460-462)gaG>gaA	p.E154E	KCNG4_ENST00000308251.4_Silent_p.E154E			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	154						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						CCAGGTGGGCCTCCTCGATGC	0.652000													18	40					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12947771	12947771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:12947771G>A	ENST00000276297.4	-	15	4473	c.4064C>T	c.(4063-4065)tCc>tTc	p.S1355F	DLC1_ENST00000358919.2_Missense_Mutation_p.S918F|DLC1_ENST00000510318.1_5'UTR|DLC1_ENST00000520226.1_Missense_Mutation_p.S844F|DLC1_ENST00000512044.2_Missense_Mutation_p.S952F	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1355	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CTTCTTATAGGACAGCTCAGC	0.493000													18	63					0	0	1	0	0
IGHV4-4	28401	broad.mit.edu	37	14	106478263	106478263	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106478263C>T	ENST00000390596.2	-	0	258																											GCCCAATCCACTCCAGTCCCT	0.577000													13	59					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61962822	61962822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61962822C>T	ENST00000280772.1	-	12	1521	c.1330G>A	c.(1330-1332)Ggg>Agg	p.G444R	ANK3_ENST00000503366.1_Missense_Mutation_p.G427R|ANK3_ENST00000373827.2_Missense_Mutation_p.G438R	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	444					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTACATGCCCCATGAAGGCA	0.433000													16	59					0	0	1	0	0
CEACAM4	1089	broad.mit.edu	37	19	42125730	42125730	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42125730G>A	ENST00000221954.2	-	7	818	c.708C>T	c.(706-708)atC>atT	p.I236I		NM_001817.2	NP_001808.2	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4	236						integral to plasma membrane|membrane fraction				NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						CTTTGTGGTCGATCTGGCAGT	0.527000													48	108					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53671347	53671347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53671347C>T	ENST00000257934.4	+	10	2270	c.2179C>T	c.(2179-2181)Cgt>Tgt	p.R727C	ESPL1_ENST00000552462.1_Missense_Mutation_p.R727C	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	727					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CCAGGAAGATCGTTTCCTATA	0.502000													21	80					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57746631	57746631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57746631C>T	ENST00000302804.7	+	7	962	c.776C>T	c.(775-777)cCa>cTa	p.P259L	AURKC_ENST00000448930.1_Missense_Mutation_p.P225L|AURKC_ENST00000598785.1_Missense_Mutation_p.P225L|AURKC_ENST00000599062.1_Missense_Mutation_p.P256L|AURKC_ENST00000415300.2_Missense_Mutation_p.P240L	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	259	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		GTGAGGTTTCCACTATCAATG	0.517000													17	36					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95057176	95057176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95057176C>T	ENST00000329597.7	+	5	1191	c.981C>T	c.(979-981)ttC>ttT	p.F327F	SERPINA5_ENST00000554866.1_Silent_p.F327F|SERPINA5_ENST00000553780.1_Silent_p.F327F|SERPINA5_ENST00000554276.1_Silent_p.F327F	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	327					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GTAACGTCTTCACCTCCCATG	0.522000													30	78					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167645800	167645800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167645800C>T	ENST00000519204.1	+	22	4659	c.4541C>T	c.(4540-4542)tCc>tTc	p.S1514F	TENM2_ENST00000403607.2_Missense_Mutation_p.S1459F|TENM2_ENST00000545108.1_Missense_Mutation_p.S1634F|TENM2_ENST00000518659.1_Missense_Mutation_p.S1635F|TENM2_ENST00000520394.1_Missense_Mutation_p.S1396F					teneurin transmembrane protein 2																		AATGGGAATTCCCTGAAGATC	0.498000													41	83					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683752	159683752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159683752C>T	ENST00000255030.5	-	2	341	c.238G>A	c.(238-240)Gag>Aag	p.E80K	CRP_ENST00000368111.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000368110.1_Intron|CRP_ENST00000437342.1_5'UTR	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	80	Pentaxin.			Missing (in Ref. 13; AA sequence).|YSIFSYATKRQDNEIL -> TVFSRMPPRDKTMRFF (in Ref. 4; CAA39671).	acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	ATGAGAATCTCATTGTCTTGT	0.453000													7	102					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102713470	102713470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102713470G>A	ENST00000299855.5	-	2	539	c.283C>T	c.(283-285)Cct>Tct	p.P95S		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	95					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CCAACATCAGGAACTCCACAC	0.493000													17	38					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28343065	28343065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28343065C>T	ENST00000337532.5	-	18	1936	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K	MPP7_ENST00000540098.1_Missense_Mutation_p.E554K|MPP7_ENST00000375719.3_Missense_Mutation_p.E554K|MPP7_ENST00000375732.1_Missense_Mutation_p.E554K	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	554	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						GTTTTGAGCTCATTGAATGCC	0.328000													18	38					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	70880876	70880876	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:70880876G>A	ENST00000333538.5	+	4	1225	c.589_splice	c.e4-1	p.E197_splice	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	197	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CATTTGCAGAGGAGCTGAAGG	0.483000													11	34					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113295194	113295194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113295194G>A	ENST00000362072.3	-	2	524	c.180C>T	c.(178-180)tcC>tcT	p.S60S	DRD2_ENST00000544518.1_Silent_p.S60S|DRD2_ENST00000542968.1_Silent_p.S60S|DRD2_ENST00000346454.3_Silent_p.S60S|DRD2_ENST00000538967.1_Silent_p.S60S|DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000355319.2_Silent_p.S60S	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	60					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding	p.S60S(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CCTTCTCGCGGGACACAGCCA	0.612000													22	56					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916519	42916519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42916519C>T	ENST00000316161.4	-	1	1114	c.790G>A	c.(790-792)Gag>Aag	p.E264K	ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Missense_Mutation_p.E264K	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	264					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity	p.E264K(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		ACCCCCTGCTCCCTCAGAAAC	0.577000													8	19					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47532724	47532724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47532724G>A	ENST00000300527.4	+	4	825	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	COL6A2_ENST00000397763.1_Missense_Mutation_p.E241K|COL6A2_ENST00000460886.1_3'UTR|COL6A2_ENST00000409416.1_Missense_Mutation_p.E241K|COL6A2_ENST00000310645.5_Missense_Mutation_p.E241K|COL6A2_ENST00000357838.4_Missense_Mutation_p.E241K	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	241	Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GCAGAAACACGAAGCCTACGG	0.642000													13	71					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4924939	4924939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:4924939G>A	ENST00000333703.4	+	4	555	c.42G>A	c.(40-42)cgG>cgA	p.R14R	PCDH11Y_ENST00000215473.6_Silent_p.R25R|PCDH11Y_ENST00000362095.5_Silent_p.R25R	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	25					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GTGTTGTGCGGGTTAATACAA	0.428000													28	35					0	0	1	0	0
LHX1	3975	broad.mit.edu	37	17	35300245	35300245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:35300245C>T	ENST00000254457.5	+	5	2449	c.1038C>T	c.(1036-1038)atC>atT	p.I346I	RP11-445F12.2_ENST00000607336.1_RNA	NM_005568.3	NP_005559.2	P48742	LHX1_HUMAN	LIM homeobox 1	346					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Breast(25;0.00607)				TTACCGACATCCTGGCGCACC	0.741000													6	6					0	0	1	0	0
GALP	85569	broad.mit.edu	37	19	56696615	56696615	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56696615G>A	ENST00000357330.2	+	6	409	c.327G>A	c.(325-327)aaG>aaA	p.K109K	GALP_ENST00000440823.1_3'UTR	NM_033106.3	NP_149097.1	Q9UBC7	GALP_HUMAN	galanin-like peptide	109					neuropeptide signaling pathway	extracellular region	hormone activity			lung(4)	4		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		AAATTCCCAAGGAGGAAGATG	0.448000													15	39					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198721736	198721736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:198721736G>A	ENST00000367376.2	+	31	3509	c.3338G>A	c.(3337-3339)cGa>cAa	p.R1113Q	PTPRC_ENST00000594404.1_Missense_Mutation_p.R952Q|PTPRC_ENST00000442510.2_Missense_Mutation_p.R1115Q|PTPRC_ENST00000352140.3_Missense_Mutation_p.R1065Q|PTPRC_ENST00000348564.6_Missense_Mutation_p.R954Q	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1113	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AAAGACTCTCGAACTGTGTAC	0.368000													6	24					0	0	1	0	0
EPS8L2	64787	broad.mit.edu	37	11	721583	721583	+	Silent	SNP	C	C	T	rs144181589		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:721583C>T	ENST00000533256.1	+	11	1162	c.787C>T	c.(787-789)Ctg>Ttg	p.L263L	EPS8L2_ENST00000526198.1_Silent_p.L279L|EPS8L2_ENST00000530636.1_Silent_p.L263L|EPS8L2_ENST00000318562.8_Silent_p.L263L|AP006621.9_ENST00000527021.2_RNA			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	263						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAACTGCGCCCTGGACGACAT	0.627000													13	20					0	0	1	0	0
PDHA1	5160	broad.mit.edu	37	X	19377730	19377730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:19377730C>T	ENST00000379806.5	+	12	1391	c.1246C>T	c.(1246-1248)Cgt>Tgt	p.R416C	PDHA1_ENST00000540249.1_Missense_Mutation_p.R347C|PDHA1_ENST00000478795.1_3'UTR|PDHA1_ENST00000422285.2_Missense_Mutation_p.R378C|PDHA1_ENST00000545074.1_Missense_Mutation_p.R385C|PDHA1_ENST00000379804.1_Missense_Mutation_p.R97C	NM_001173454.1	NP_001166925.1	P08559	ODPA_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 1	378					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity	p.R378C(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)	18	Hepatocellular(33;0.183)				NADH(DB00157)	TTTTGAAGTTCGTGGTGCCAA	0.527000													32	23					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41430259	41430259	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41430259G>A	ENST00000599198.1	+	0	136					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TAACTCCCATGGCACCCTCCC	0.587000													27	72					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6422854	6422854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6422854C>T	ENST00000449001.2	+	2	596	c.102C>T	c.(100-102)gcC>gcT	p.A34A	PLEKHG6_ENST00000011684.7_Silent_p.A66A|PLEKHG6_ENST00000536531.1_Silent_p.A66A|PLEKHG6_ENST00000396988.3_Silent_p.A66A	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	66					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						CTGGCCAGGCCCGAGGCCTGT	0.642000													30	66					0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130095457	130095457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130095457G>A	ENST00000265379.6	+	3	939	c.445G>A	c.(445-447)Gaa>Aaa	p.E149K	COL6A5_ENST00000432398.2_Missense_Mutation_p.E149K			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	149	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						GTCTGAGGATGAAGTGGAAGA	0.522000													10	17					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21175852	21175852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21175852G>A	ENST00000381541.3	+	5	615	c.550G>A	c.(550-552)Ggg>Agg	p.G184R	LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.G137R|SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.G184R																							TCGTGGCATAGGGGAAACCCC	0.368000													15	123					0	0	1	0	0
HRH2	3274	broad.mit.edu	37	5	175110674	175110674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:175110674C>T	ENST00000231683.2	+	1	2211	c.438C>T	c.(436-438)tcC>tcT	p.S146S	HRH2_ENST00000377291.2_Silent_p.S146S	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	146					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	GGGTCATCTCCATTACCCTGT	0.557000													18	43					0	0	1	0	0
ZNF33A	7581	broad.mit.edu	37	10	38353019	38353019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:38353019C>T	ENST00000469037.2	+	6	533	c.391C>T	c.(391-393)Cct>Tct	p.P131S				Q06730	ZN33A_HUMAN	zinc finger protein 33A	58						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						CTCCCAGGCCCCTGAGATGCT	0.512000													44	95					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38997934	38997934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38997934G>A	ENST00000359357.3	+	91	13493	c.13239G>A	c.(13237-13239)cgG>cgA	p.R4413R	DNAH8_ENST00000441566.1_Silent_p.R4377R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GGGACAGACGGAATGGGAAGC	0.488000											OREG0017409	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	87					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226822414	226822414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226822414G>A	ENST00000429204.1	-	8	3126	c.2799C>T	c.(2797-2799)gtC>gtT	p.V933V	ITPKB_ENST00000272117.3_Silent_p.V933V	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	933							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				TCAGGATGTCGACGAGGTTAT	0.667000													14	26					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52605227	52605227	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52605227G>A	ENST00000591504.1	-	5	580	c.306C>T	c.(304-306)ctC>ctT	p.L102L	CCDC68_ENST00000432185.1_Silent_p.L102L|CCDC68_ENST00000337363.4_Silent_p.L102L	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	102										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TCATTTCTAAGAGCTGTAGGT	0.353000													5	47					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009273	9009273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9009273G>A	ENST00000397910.4	-	40	39403	c.39200C>T	c.(39199-39201)tCt>tTt	p.S13067F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13069	SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCACCTGAGAGAGATCAGTCT	0.507000													24	72					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250254	140250254	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140250254G>A	ENST00000398640.2	+	1	1566	c.1566G>A	c.(1564-1566)ttG>ttA	p.L522L	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGCCGTTGGACCACGAGG	0.682000													55	149					0	0	1	0	0
ARL6	84100	broad.mit.edu	37	3	97503890	97503890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97503890C>T	ENST00000463745.1	+	5	823	c.346C>T	c.(346-348)Cca>Tca	p.P116S	ARL6_ENST00000496713.1_3'UTR|ARL6_ENST00000335979.2_Missense_Mutation_p.P116S|ARL6_ENST00000394206.1_Missense_Mutation_p.P116S	NM_001278293.1	NP_001265222.1	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	116					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding			large_intestine(1)|lung(4)	5		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		TCTGAATCATCCAGGTATGTG	0.343000													15	74					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145001728	145001728	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145001728G>A	ENST00000322810.4	-	27	4186	c.4017C>T	c.(4015-4017)ctC>ctT	p.L1339L	PLEC_ENST00000354589.3_Silent_p.L1202L|PLEC_ENST00000357649.2_Silent_p.L1206L|PLEC_ENST00000527096.1_Silent_p.L1225L|PLEC_ENST00000356346.3_Silent_p.L1188L|PLEC_ENST00000354958.2_Silent_p.L1180L|PLEC_ENST00000345136.3_Silent_p.L1202L|PLEC_ENST00000436759.2_Silent_p.L1229L|PLEC_ENST00000398774.2_Silent_p.L1170L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1339	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCAGTTGCTCGAGCTCGCGCT	0.716000													3	10					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48596379	48596379	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48596379G>A	ENST00000323776.5	+	6	988	c.826G>A	c.(826-828)Gag>Aag	p.E276K	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.E239K	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	239					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GCACACCGGGGAGACCTACAG	0.582000													19	50					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14854482	14854482	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14854482G>A	ENST00000315576.3	-	19	2749	c.2298C>T	c.(2296-2298)atC>atT	p.I766I	EMR2_ENST00000596991.2_Silent_p.I755I|EMR2_ENST00000594294.1_Silent_p.I717I|EMR2_ENST00000594076.1_Silent_p.I673I|EMR2_ENST00000392967.2_Silent_p.I755I|EMR2_ENST00000595839.1_Silent_p.I624I|EMR2_ENST00000353876.1_Silent_p.I673I|EMR2_ENST00000601345.1_Silent_p.I755I|EMR2_ENST00000346057.1_Silent_p.I717I|EMR2_ENST00000353005.1_Silent_p.I624I|EMR2_ENST00000392965.3_Silent_p.I708I	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	766					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						GCAGGCTGTTGATGATGGTGA	0.607000													58	127					0	0	1	0	0
RCC2	55920	broad.mit.edu	37	1	17739641	17739641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17739641G>A	ENST00000375436.4	-	10	1428	c.1241C>T	c.(1240-1242)tCc>tTc	p.S414F	RCC2_ENST00000375433.3_Missense_Mutation_p.S414F	NM_018715.3	NP_061185.1	Q9P258	RCC2_HUMAN	regulator of chromosome condensation 2	414					cell division|mitotic prometaphase	chromosome, centromeric region|cytosol|microtubule|nucleolus|spindle				breast(2)|endometrium(1)|kidney(3)|large_intestine(7)|lung(4)	17		Colorectal(325;0.000147)|Breast(348;0.00122)|Renal(390;0.00145)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;7.69e-06)|COAD - Colon adenocarcinoma(227;1.19e-05)|Kidney(64;0.000189)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.0135)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)		AGATTCACGGGAGGTGTTGGT	0.542000													10	28					0	0	1	0	0
DCUN1D3	123879	broad.mit.edu	37	16	20873685	20873685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20873685G>A	ENST00000324344.3	-	2	461	c.176C>T	c.(175-177)gCc>gTc	p.A59V	DCUN1D3_ENST00000563934.1_Missense_Mutation_p.A59V|ERI2_ENST00000564349.1_Intron	NM_173475.2	NP_775746.1	Q8IWE4	DCNL3_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 3	59					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of apoptosis|response to gamma radiation|response to UV-C	perinuclear region of cytoplasm				NS(2)|breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)	14				GBM - Glioblastoma multiforme(48;0.249)		GGCAGCCTCGGCCTTCTTGGT	0.597000													83	159					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7684729	7684729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7684729G>A	ENST00000358368.4	-	18	2447	c.2410C>T	c.(2410-2412)Cgg>Tgg	p.R804W	XAB2_ENST00000534844.1_Missense_Mutation_p.R801W	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	804					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						AGCTCCTCCCGGGAGGCGTCA	0.682000								Direct reversal of damage;Nucleotide excision repair (NER)					35	128					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56638912	56638912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56638912G>A	ENST00000267116.7	-	22	2588	c.2467C>T	c.(2467-2469)Ccc>Tcc	p.P823S		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	823							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						GGAGTGAAGGGGTTTCCTTCC	0.512000													10	159					0	0	1	0	0
ECM2	1842	broad.mit.edu	37	9	95263230	95263230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95263230C>T	ENST00000344604.5	-	9	1859	c.1710G>A	c.(1708-1710)cgG>cgA	p.R570R	ECM2_ENST00000444490.2_Silent_p.R548R|CENPP_ENST00000375587.3_Intron	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	570					cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						AGCCAGGGATCCGTTCAATCT	0.483000													20	74					0	0	1	0	0
RBMS3	27303	broad.mit.edu	37	3	29628666	29628666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:29628666G>A	ENST00000434693.2	+	4	1066	c.366G>A	c.(364-366)aaG>aaA	p.K122K	RBMS3_ENST00000383766.2_Silent_p.K122K|RBMS3_ENST00000273139.9_Silent_p.K123K|RBMS3_ENST00000396583.3_Silent_p.K123K|RBMS3_ENST00000456853.1_Silent_p.K123K|RBMS3_ENST00000452462.1_Silent_p.K123K|RBMS3_ENST00000383767.2_Silent_p.K123K|RBMS3_ENST00000445033.1_Silent_p.K123K	NM_001003793.2	NP_001003793.1	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting protein 3	123	RRM 1.					cytoplasm	nucleotide binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	11		Ovarian(412;0.0956)				CATCTCTCAAGGCAAATGGCG	0.398000													5	81					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153133547	153133547	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153133547G>A	ENST00000370060.1	-	15	1923	c.1734C>T	c.(1732-1734)atC>atT	p.I578I	L1CAM_ENST00000370057.3_Silent_p.I578I|L1CAM_ENST00000370055.1_Silent_p.I573I|L1CAM_ENST00000361981.3_Silent_p.I573I|L1CAM_ENST00000361699.4_Silent_p.I578I|L1CAM_ENST00000538883.1_Silent_p.I580I|L1CAM_ENST00000543994.1_Silent_p.I580I	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	578	Ig-like C2-type 6.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGGCTGTGGATGACCAGGC	0.597000													7	33					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27289779	27289779	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27289779C>T	ENST00000397501.1	+	15	1696	c.888C>T	c.(886-888)ccC>ccT	p.P296P	PTK2B_ENST00000517339.1_Silent_p.P296P|PTK2B_ENST00000346049.5_Silent_p.P296P|PTK2B_ENST00000338238.4_Silent_p.P296P|PTK2B_ENST00000397497.4_Silent_p.P42P|PTK2B_ENST00000544172.1_Silent_p.P296P|PTK2B_ENST00000420218.2_Silent_p.P296P	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	296	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TCCCACAGCCCACCTGCCTGG	0.622000													8	23					0	0	1	0	0
FBLIM1	54751	broad.mit.edu	37	1	16097048	16097048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16097048G>A	ENST00000375766.3	+	6	1326	c.686G>A	c.(685-687)cGa>cAa	p.R229Q	FBLIM1_ENST00000375771.1_Missense_Mutation_p.R229Q|FBLIM1_ENST00000332305.5_Missense_Mutation_p.R132Q|FBLIM1_ENST00000441801.2_Missense_Mutation_p.R229Q|FBLIM1_ENST00000400773.1_Missense_Mutation_p.R132Q	NM_017556.2	NP_060026.2	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	229	LIM zinc-binding 1.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		AAGGATGGGCGACCCCTCTGC	0.607000													16	39					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21249714	21249714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21249714G>A	ENST00000233242.1	-	15	2317	c.2190C>T	c.(2188-2190)gtC>gtT	p.V730V	APOB_ENST00000399256.4_Silent_p.V730V	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	730			V -> I (in dbSNP:rs12691202).		cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGACCTTAGAGACACCATCAG	0.413000													33	96					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551632	35551632	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35551632G>A	ENST00000262626.2	+	9	1547	c.722G>A	c.(721-723)gGg>gAg	p.G241E	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Missense_Mutation_p.G83E|HPN_ENST00000392226.1_Missense_Mutation_p.G241E	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	241	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GTCTACCACGGGGGCTATCTT	0.642000													25	75					0	0	1	0	0
TUBA4B	80086	broad.mit.edu	37	2	220136346	220136346	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220136346G>A	ENST00000490341.1	+	0	816					NR_003063.1																						CATCTCTGCAGAAAAGGTATA	0.557000													15	83					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84438821	84438821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84438821G>A	ENST00000416219.2	+	3	387	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	ATP2C2_ENST00000262429.4_Missense_Mutation_p.E100K			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	100					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						TGACAACAGCGAACCTGTGTG	0.547000													5	42					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118228010	118228010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:118228010C>T	ENST00000402510.2	-	9	1315	c.1316G>A	c.(1315-1317)gGa>gAa	p.G439E		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	439										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CTGCAGGGATCCCTCTAAAAT	0.473000													24	20					0	0	1	0	0
VWCE	220001	broad.mit.edu	37	11	61053825	61053825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61053825G>A	ENST00000335613.5	-	5	888	c.502C>T	c.(502-504)Ccg>Tcg	p.P168S		NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	168	EGF-like 2; calcium-binding (Potential).					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TGCATGCCCGGCCCACACTCG	0.572000													75	139					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49897923	49897923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49897923C>T	ENST00000477224.1	-	9	1313	c.835G>A	c.(835-837)Gag>Aag	p.E279K	CAMKV_ENST00000463537.1_Missense_Mutation_p.E279K|CAMKV_ENST00000296471.7_Missense_Mutation_p.E251K|CAMKV_ENST00000467248.1_Missense_Mutation_p.E204K|CAMKV_ENST00000466940.1_Missense_Mutation_p.E236K|CAMKV_ENST00000488336.1_Missense_Mutation_p.E279K			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	279	Protein kinase.		E -> D (in dbSNP:rs56071455).			cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GAGATGGCCTCTTCTGCAGTG	0.612000													4	21					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138202199	138202199	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:138202199C>T	ENST00000237289.4	+	9	2182	c.2116C>T	c.(2116-2118)Cga>Tga	p.R706*		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	706	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		AGATGTGCCTCGAACCACACA	0.542000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								18	55					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454440	84454440	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:84454440G>A	ENST00000377084.2	-	1	2088	c.1203C>T	c.(1201-1203)ctC>ctT	p.L401L		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	401						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCAACAGAATGAGGTTCTTGT	0.438000													92	267					0	0	1	0	0
SAP130	79595	broad.mit.edu	37	2	128775310	128775310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128775310G>A	ENST00000357702.5	-	3	501	c.370C>T	c.(370-372)Ccg>Tcg	p.P124S	SAP130_ENST00000259235.3_Missense_Mutation_p.P124S|SAP130_ENST00000259234.6_Missense_Mutation_p.P98S	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	124	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TGTGCTGGCGGGGCTGTCACT	0.537000													8	75					0	0	1	0	0
NR1I2	8856	broad.mit.edu	37	3	119535955	119535955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119535955C>T	ENST00000393716.2	+	9	3040	c.1201C>T	c.(1201-1203)Cgc>Tgc	p.R401C	NR1I2_ENST00000337940.4_Missense_Mutation_p.R440C|NR1I2_ENST00000466380.1_Missense_Mutation_p.R364C	NM_003889.3	NP_003880.3	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	401	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	CACCGAGCTCCGCAGCATCAA	0.582000													37	64					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34269257	34269257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:34269257G>A	ENST00000346562.2	+	11	1722	c.1648G>A	c.(1648-1650)Gac>Aac	p.D550N	NPAS3_ENST00000551492.1_Missense_Mutation_p.D587N|NPAS3_ENST00000357798.5_Missense_Mutation_p.D569N|NPAS3_ENST00000548645.1_Missense_Mutation_p.D552N|NPAS3_ENST00000356141.4_Missense_Mutation_p.D582N	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	582					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CAGCGCCAAGGACTCGGACAG	0.672000													6	15					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111184	7111184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7111184C>T	ENST00000306904.5	+	1	1020	c.833C>T	c.(832-834)tCc>tTc	p.S278F		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	278	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGCAGAGGCTCCCATCGAGAG	0.657000													23	42					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882455	144882455	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:144882455A>G	ENST00000369359.4	-	27	4013	c.3975T>C	c.(3973-3975)gaT>gaC	p.D1325D	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369356.4_Silent_p.D1188D|PDE4DIP_ENST00000369354.3_Silent_p.D1188D|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000530740.1_Silent_p.D1325D			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1188					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTTGGTGGGCATCCACTGTGA	0.502000			T	PDGFRB	MPD								13	71					0	0	1	0	0
CNTRL	11064	broad.mit.edu	37	9	123929839	123929839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123929839G>A	ENST00000373855.1	+	37	5988	c.5728G>A	c.(5728-5730)Gaa>Aaa	p.E1910K	CNTRL_ENST00000373845.2_3'UTR|CNTRL_ENST00000373850.1_Missense_Mutation_p.E1358K|CNTRL_ENST00000238341.5_Missense_Mutation_p.E1910K			Q7Z7A1	CNTRL_HUMAN	centriolin	1910					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(2)|ovary(4)|skin(3)	20						GGACATCAGTGAATGGGCAAA	0.433000													18	39					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3432637	3432637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3432637C>T	ENST00000336727.3	+	17	4973	c.4069C>T	c.(4069-4071)Ccg>Tcg	p.P1357S	RGS12_ENST00000338806.4_Missense_Mutation_p.P709S|RGS12_ENST00000382788.3_Missense_Mutation_p.P1357S|RGS12_ENST00000344733.5_Missense_Mutation_p.P1357S|RGS12_ENST00000538395.1_3'UTR	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1357						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CACCTTGCTGCCGCCGCCCTC	0.667000													14	34					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187261	140187261	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140187261G>A	ENST00000530339.1	+	1	489	c.489G>A	c.(487-489)ggG>ggA	p.G163G	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.G163G|PCDHA4_ENST00000512229.2_Silent_p.G163G|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATATCGGGGAGAACGCCC	0.522000													31	87					0	0	1	0	0
MCF2L2	23101	broad.mit.edu	37	3	183107490	183107490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183107490G>A	ENST00000328913.3	-	2	451	c.154C>T	c.(154-156)Ctt>Ttt	p.L52F	MCF2L2_ENST00000447025.2_Missense_Mutation_p.L52F|MCF2L2_ENST00000473233.1_Missense_Mutation_p.L52F|MCF2L2_ENST00000414362.2_Missense_Mutation_p.L52F	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	52	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TTACCTGAAAGAATGGCAAAT	0.433000													13	60					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56096685	56096685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56096685G>A	ENST00000257880.7	-	3	604	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	ITGA7_ENST00000553804.1_Missense_Mutation_p.R129W|ITGA7_ENST00000394229.2_Missense_Mutation_p.R129W|ITGA7_ENST00000394230.2_Missense_Mutation_p.R129W|ITGA7_ENST00000347027.6_Missense_Mutation_p.R129W|ITGA7_ENST00000257879.6_Missense_Mutation_p.R129W|ITGA7_ENST00000555728.1_Missense_Mutation_p.R129W|ITGA7_ENST00000452168.2_Intron			Q13683	ITA7_HUMAN	integrin, alpha 7	129					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity	p.R129W(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CCCTGGCTCCGAACACTGACT	0.522000													15	82					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52965784	52965784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52965784C>T	ENST00000549343.1	-	3	729	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K	KRT74_ENST00000305620.2_Missense_Mutation_p.E231K			Q7RTS7	K2C74_HUMAN	keratin 74	231	Coil 1B.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		ATCTCCACTTCATATCTGCCA	0.537000													14	104					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26988280	26988280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:26988280C>T	ENST00000231021.4	-	2	333	c.161G>A	c.(160-162)gGc>gAc	p.G54D		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	54	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CCACATCCAGCCACGCTTGGT	0.388000													16	38					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50154532	50154532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50154532C>T	ENST00000360565.3	+	7	1010	c.886C>T	c.(886-888)Cgc>Tgc	p.R296C		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	296					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GAGCATCAGCCGCATCTCGGA	0.642000													14	23					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171323129	171323129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171323129G>A	ENST00000334231.6	+	25	2949	c.2949G>A	c.(2947-2949)ctG>ctA	p.L983L	MYO3B_ENST00000408978.4_Silent_p.L974L|MYO3B_ENST00000409044.3_Silent_p.L974L|MYO3B_ENST00000602629.1_Intron			Q8WXR4	MYO3B_HUMAN	myosin IIIB	974	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						AGAGGGTGCTGGCCCAGCTCC	0.557000													35	121					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10468287	10468287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10468287C>T	ENST00000382483.3	-	4	3544	c.3321G>A	c.(3319-3321)atG>atA	p.M1107I		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1107					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GCCTCCTGGCCATGGGCCTAG	0.627000													25	104					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940539	22940539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22940539C>T	ENST00000397104.3	-	5	1898	c.1899G>A	c.(1897-1899)gaG>gaA	p.E633E	ZNF99_ENST00000596209.1_Silent_p.E724E					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATGAATTATCTCATGTTTTC	0.363000													24	70					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919366	4919366	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4919366G>A	ENST00000433855.1	+	1	1025	c.159G>A	c.(157-159)gaG>gaA	p.E53E	KCNA6_ENST00000280684.3_Silent_p.E53E	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	53						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						TGCGCTTTGAGACACAATTGC	0.642000										HNSCC(72;0.22)			31	47					0	0	1	0	0
LYZL2	119180	broad.mit.edu	37	10	30918621	30918621	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30918621G>C	ENST00000375318.2	-	1	70	c.14C>G	c.(13-15)cCc>cGc	p.P5R		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	0					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				GCAGCTCAGGGGAGCGTCCTG	0.502000													8	44					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48915876	48915876	+	Missense_Mutation	SNP	C	C	T	rs121912529		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48915876C>T	ENST00000294954.7	-	11	1081	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Missense_Mutation_p.E327K|LHCGR_ENST00000401907.1_Intron|LHCGR_ENST00000403273.1_Intron|LHCGR_ENST00000344775.3_Missense_Mutation_p.E292K	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	354			E -> K (in LHR; Leydig cell hypoplasia type 1).		male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	ATAATATCTTCACAGGGATTA	0.443000													25	135					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123038613	123038613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123038613G>A	ENST00000462833.1	-	10	3376	c.2164C>T	c.(2164-2166)Cgt>Tgt	p.R722C	ADCY5_ENST00000491190.1_Missense_Mutation_p.R355C|ADCY5_ENST00000309879.5_Missense_Mutation_p.R372C	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	722					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		TCAATGGCACGGCCCAGAAAC	0.592000													11	36					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803019	54803019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54803019G>A	ENST00000391745.1	-	8	1025	c.709C>T	c.(709-711)Cca>Tca	p.P237S	LILRA3_ENST00000391744.3_Intron|LILRA3_ENST00000251390.3_Missense_Mutation_p.P220S					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTCTCACCTGGGACCAGGAGC	0.612000													35	101					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118230488	118230488	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:118230488G>A	ENST00000402510.2	-	8	1234	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	412										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TTGTTTGCGGGGATTTAAAGT	0.468000													13	14					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968393	28968393	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28968393C>T	ENST00000359747.4	+	4	309	c.280C>T	c.(280-282)Cga>Tga	p.R94*	DSG4_ENST00000308128.4_Nonsense_Mutation_p.R94*|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	94	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGGGATTGATCGACCACCATA	0.408000													16	64					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14341131	14341131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:14341131C>T	ENST00000571589.1	+	12	2186	c.2014C>T	c.(2014-2016)Ctt>Ttt	p.L672F	MKL2_ENST00000574045.1_Missense_Mutation_p.L672F|MKL2_ENST00000341243.5_Missense_Mutation_p.L661F|MKL2_ENST00000318282.5_Missense_Mutation_p.L672F	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	661	Gln-rich.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TGGCCAGACCCTTGTTGCCAA	0.582000													28	51					0	0	1	0	0
OR2A14	135941	broad.mit.edu	37	7	143827007	143827007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143827007G>A	ENST00000408899.2	+	1	857	c.802G>A	c.(802-804)Gag>Aag	p.E268K		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					CCATCCTGAGGAGCAGCAGAA	0.542000													65	173					0	0	1	0	0
OR8B8	26493	broad.mit.edu	37	11	124310178	124310178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124310178C>T	ENST00000328064.2	-	1	876	c.804G>A	c.(802-804)atG>atA	p.M268I		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGCCCTGGTTCATAGCTAAAA	0.453000													25	48					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41552569	41552569	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41552569C>T	ENST00000373060.1	+	4	821	c.363C>T	c.(361-363)atC>atT	p.I121I	FOXP4_ENST00000409208.1_Silent_p.I121I|FOXP4_ENST00000373063.3_Silent_p.I121I|FOXP4_ENST00000307972.4_Silent_p.I121I|FOXP4_ENST00000373057.3_Silent_p.I121I	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	121	Gln-rich.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					TGCAGCAGATCCTGTCGCCCC	0.662000													9	22					0	0	1	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789314	140789314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140789314C>T	ENST00000520790.1	+	1	1545	c.1545C>T	c.(1543-1545)ttC>ttT	p.F515F	PCDHGA9_ENST00000573521.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGTGTTCGCGCAGCGCG	0.667000													4	23					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45936027	45936027	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45936027G>A	ENST00000374391.2	+	8	1184	c.1131G>A	c.(1129-1131)gaG>gaA	p.E377E	ALOX5_ENST00000542434.1_Silent_p.E377E	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	377	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	TGGTGTCTGAGGTTTTTGGCA	0.542000													17	38					0	0	1	0	0
RNF180	285671	broad.mit.edu	37	5	63509401	63509401	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:63509401G>A	ENST00000389100.4	+	4	320	c.248G>A	c.(247-249)gGa>gAa	p.G83E	RNF180_ENST00000296615.6_Missense_Mutation_p.G83E|RNF180_ENST00000381081.2_Intron	NM_001113561.1	NP_001107033.1	Q86T96	RN180_HUMAN	ring finger protein 180	83						integral to membrane|nuclear envelope	zinc ion binding			breast(1)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	20		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		TGGACAGTTGGAAAACTGAAT	0.418000													80	183					0	0	1	0	0
RNASEH2B	79621	broad.mit.edu	37	13	51522143	51522143	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:51522143C>A	ENST00000336617.3	+	8	1036	c.637C>A	c.(637-639)Cat>Aat	p.H213N	RNASEH2B_ENST00000422660.1_Missense_Mutation_p.H213N|RNASEH2B_ENST00000495244.2_3'UTR	NM_024570.3	NP_078846.2	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B	213					RNA catabolic process	nucleus|ribonuclease H2 complex				endometrium(2)|liver(1)|lung(1)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		TCGTTATGCCCATGGTCTGAT	0.308000													43	173					4.00472e-15	4.02613e-15	1	1	0
C3orf67	200844	broad.mit.edu	37	3	58849567	58849567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58849567C>T	ENST00000472469.1	-	11	1494	c.656G>A	c.(655-657)aGc>aAc	p.S219N	C3orf67_ENST00000482387.1_Missense_Mutation_p.S312N|RP11-147N17.1_ENST00000492031.1_RNA|C3orf67_ENST00000295966.7_Missense_Mutation_p.S312N|RP11-147N17.1_ENST00000463703.1_RNA|RP11-147N17.1_ENST00000493123.1_RNA|RP11-147N17.1_ENST00000482372.1_RNA			Q6ZVT6	CC067_HUMAN	chromosome 3 open reading frame 67	312										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		AGACTGTCTGCTGGATGCCAG	0.453000													16	58					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95932532	95932532	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95932532G>A	ENST00000334258.5	-	3	377	c.363C>T	c.(361-363)gcC>gcT	p.A121A	SYNE3_ENST00000557275.1_Silent_p.A121A|SYNE3_ENST00000553340.1_Silent_p.A121A	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3									p.A121A(1)		breast(1)|endometrium(2)|lung(25)	28						ACTCATCTCGGGCCAGCAGGT	0.617000													19	102					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101765751	101765751	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101765751G>A	ENST00000334289.3	-	8	1301	c.706C>T	c.(706-708)Cag>Tag	p.Q236*		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	236	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		GTATTTTTCTGATTTACTATA	0.284000													16	55					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89128865	89128865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:89128865C>T	ENST00000286614.6	-	6	1235	c.954G>A	c.(952-954)agG>agA	p.R318R	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	318					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						TGTCATTTTTCCTTGGGTCAG	0.527000													50	118					0	0	1	0	0
EEA1	8411	broad.mit.edu	37	12	93244932	93244932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:93244932G>A	ENST00000322349.8	-	9	1017	c.753C>T	c.(751-753)ctC>ctT	p.L251L		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	251					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						ATTCATCTTTGAGTTTTTCAG	0.368000													17	59					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951748	119951748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119951748C>T	ENST00000307142.4	+	4	2014	c.1818C>T	c.(1816-1818)acC>acT	p.T606T	SYNPO2_ENST00000434046.2_Silent_p.T606T|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Silent_p.T606T	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	606	Pro-rich.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TCTCGCCAACCCGAAACATGA	0.557000													33	135					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402533	248402533	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248402533A>C	ENST00000306687.1	+	1	303	c.303A>C	c.(301-303)atA>atC	p.I101I		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GAACTCAGATATTCTTCTATG	0.463000													39	84					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65789296	65789296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65789296G>A	ENST00000312106.5	-	3	1621	c.1484C>T	c.(1483-1485)gCc>gTc	p.A495V		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	495					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CTTGAGCAGGGCTTCCACCAC	0.572000													14	103					0	0	1	0	0
TRAV8-2	28684	broad.mit.edu	37	14	22315315	22315315	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22315315G>A	ENST00000390434.3	+	0	478																											TTTTGAGGCTGAATTTAAGAA	0.502000											OREG0022570	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	61	141					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21687424	21687424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:21687424C>T	ENST00000398485.2	+	2	689	c.635C>T	c.(634-636)cCt>cTt	p.P212L	PAX1_ENST00000460221.1_Intron|PAX1_ENST00000444366.2_Missense_Mutation_p.P188L	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	212	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						TACAATGTGCCTTCGGTGAGC	0.632000													45	72					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82416145	82416145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:82416145C>T	ENST00000370728.1	+	9	2116	c.1471C>T	c.(1471-1473)Cca>Tca	p.P491S	LPHN2_ENST00000359929.3_Missense_Mutation_p.P491S|LPHN2_ENST00000394879.1_Missense_Mutation_p.P491S|LPHN2_ENST00000370730.1_Missense_Mutation_p.P491S|LPHN2_ENST00000271029.4_Missense_Mutation_p.P491S|LPHN2_ENST00000370715.1_Missense_Mutation_p.P491S|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000335786.5_Missense_Mutation_p.P491S|LPHN2_ENST00000370725.1_Missense_Mutation_p.P491S|LPHN2_ENST00000370723.1_Missense_Mutation_p.P491S|LPHN2_ENST00000370721.1_Missense_Mutation_p.P429S|LPHN2_ENST00000370713.1_Missense_Mutation_p.P491S|LPHN2_ENST00000319517.6_Missense_Mutation_p.P491S|LPHN2_ENST00000370717.2_Missense_Mutation_p.P491S|LPHN2_ENST00000370727.1_Missense_Mutation_p.P491S			O95490	LPHN2_HUMAN	latrophilin 2	491					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GGTTGAACGACCATGCCCTAA	0.378000													22	68					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7619939	7619939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7619939C>T	ENST00000221249.6	+	25	3112	c.2681C>T	c.(2680-2682)tCg>tTg	p.S894L	PNPLA6_ENST00000450331.3_Missense_Mutation_p.S894L|PNPLA6_ENST00000414982.3_Missense_Mutation_p.S942L|PNPLA6_ENST00000545201.2_Missense_Mutation_p.S867L|PNPLA6_ENST00000600737.1_Missense_Mutation_p.S932L	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	933					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						CGCCTCTTTTCGCGCCGCAGC	0.731000													6	8					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121630439	121630439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121630439C>T	ENST00000489711.1	+	4	742	c.354C>T	c.(352-354)tcC>tcT	p.S118S	SLC15A2_ENST00000295605.2_Intron	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	118					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TCTATCTCTCCTTGGTGTATG	0.418000													15	43					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119441727	119441727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119441727C>T	ENST00000369429.3	-	7	957	c.948G>A	c.(946-948)atG>atA	p.M316I	TBX15_ENST00000207157.3_Missense_Mutation_p.M210I			Q96SF7	TBX15_HUMAN	T-box 15	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CATATGTCTCCATGATGGCTT	0.468000													18	44					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148627436	148627436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148627436C>T	ENST00000506113.1	+	17	2125	c.1643C>T	c.(1642-1644)tCc>tTc	p.S548F	ABLIM3_ENST00000326685.7_Missense_Mutation_p.S453F|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000508983.1_Missense_Mutation_p.S515F|ABLIM3_ENST00000309868.7_Missense_Mutation_p.S548F|ABLIM3_ENST00000504238.1_Missense_Mutation_p.S437F|RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000517451.1_Missense_Mutation_p.S34F|ABLIM3_ENST00000356541.3_Missense_Mutation_p.S437F|AC012613.2_ENST00000523176.1_RNA			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	548					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGGAGCTCCACCAGCAGC	0.602000													6	31					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580266	140580266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580266C>T	ENST00000354757.3	+	1	919	c.919C>T	c.(919-921)Ctg>Ttg	p.L307L	PCDHB11_ENST00000536699.1_5'UTR	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		307	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGAGCACCTCTGGATTTTGA	0.358000													45	78					0	0	1	0	0
CELA3A	10136	broad.mit.edu	37	1	22332005	22332005	+	Silent	SNP	C	C	T	rs150719625		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22332005C>T	ENST00000290122.3	+	3	214	c.195C>T	c.(193-195)ccC>ccT	p.P65P	CELA3A_ENST00000374663.1_Silent_p.P65P	NM_005747.4	NP_005738.4			chymotrypsin-like elastase family, member 3A											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCATCGCCCCCGATTGGGTTG	0.617000											OREG0013211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	118					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177190142	177190142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:177190142G>A	ENST00000296525.3	-	1	231	c.118C>T	c.(118-120)Cat>Tat	p.H40Y		NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	40					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		ATGTAGAAATGACTGAGGATG	0.403000													26	46					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52356612	52356612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52356612C>T	ENST00000420323.2	+	2	415	c.154C>T	c.(154-156)Cct>Tct	p.P52S		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	52	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTTGGGAAATCCTCCAGCCCT	0.607000													17	54					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114267166	114267166	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114267166G>A	ENST00000357077.4	+	35	4412	c.4359G>A	c.(4357-4359)ccG>ccA	p.P1453P	ANK2_ENST00000264366.6_Silent_p.P1420P|ANK2_ENST00000506722.1_Silent_p.P1444P|ANK2_ENST00000509550.1_Silent_p.P629P|ANK2_ENST00000510275.2_Silent_p.P105P|ANK2_ENST00000394537.3_Silent_p.P1453P	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1420					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.P1453P(2)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCACTTTGCCGATTTATACAA	0.393000													14	99					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51893112	51893112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51893112C>T	ENST00000371117.3	-	30	3677	c.3402G>A	c.(3400-3402)atG>atA	p.M1134I	PKHD1_ENST00000340994.4_Missense_Mutation_p.M1134I	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1134	IPT/TIG 6; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCGTATAGTTCATCAGCCTCG	0.562000													25	86					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49958711	49958711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:49958711G>A	ENST00000376056.2	-	5	776	c.626C>T	c.(625-627)tCc>tTc	p.S209F	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000358526.2_Missense_Mutation_p.S218F|AKAP4_ENST00000376064.3_Missense_Mutation_p.S209F			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	218					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					GACGTAGAAGGAAAGGTCATC	0.438000													84	36					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86196269	86196269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86196269C>T	ENST00000370571.2	-	60	5471	c.5105G>A	c.(5104-5106)cGa>cAa	p.R1702Q	COL24A1_ENST00000436319.1_Missense_Mutation_p.R1681Q	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1702	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent	p.R1702Q(1)		NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GTAATACTTTCGTTCAGTTTT	0.413000													32	82					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18671987	18671987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18671987C>T	ENST00000308799.4	+	9	2151	c.1932C>T	c.(1930-1932)ccC>ccT	p.P644P	FBXW10_ENST00000395665.4_Silent_p.P615P|FBXW10_ENST00000301938.4_Silent_p.P615P|FBXW10_ENST00000395667.1_Silent_p.P615P			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	615										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						TCAAGCATCCCAAGTAGGTGC	0.572000													24	16					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115487056	115487056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115487056G>A	ENST00000369522.3	+	24	2263	c.2023G>A	c.(2023-2025)Gaa>Aaa	p.E675K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E675K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	675					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGATATCAGAAGAAAATCT	0.274000													16	60					0	0	1	0	0
GSTK1	373156	broad.mit.edu	37	7	142962297	142962297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142962297C>T	ENST00000479303.1	+	4	554	c.496C>T	c.(496-498)Ctc>Ttc	p.L166F	GSTK1_ENST00000358406.5_Intron|GSTK1_ENST00000443571.2_Intron|GSTK1_ENST00000409500.3_Intron|AC073342.12_ENST00000427392.1_RNA	NM_001143679.1	NP_001137151.1	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1	138						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity			lung(4)	4	Melanoma(164;0.059)				Glutathione(DB00143)	ATCTACTGTCCTCCCAGTCAC	0.602000													5	8					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101748315	101748315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101748315C>T	ENST00000375001.3	+	3	992	c.569C>T	c.(568-570)tCc>tTc	p.S190F		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	190	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				TTCCAGCGGTCCTCCCAGGCT	0.567000													24	49					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70535554	70535554	+	Missense_Mutation	SNP	C	C	T	rs112767369		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:70535554C>T	ENST00000377844.4	-	3	1462	c.703G>A	c.(703-705)Gac>Aac	p.D235N	KLHL1_ENST00000545028.1_Missense_Mutation_p.D42N	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	235	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GCAAAATAGTCGGAGACTGAA	0.448000													8	64					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83631363	83631363	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83631363C>T	ENST00000265362.3	-	12	1675		c.e12-1		SEMA3A_ENST00000436949.1_Splice_Site	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A						axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						GTCCCAACATCTTTGAAAGAA	0.373000													15	35					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19067962	19067962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19067962C>T	ENST00000421369.3	+	14	2198	c.1640C>T	c.(1639-1641)tCc>tTc	p.S547F	TMC7_ENST00000569532.1_Missense_Mutation_p.S657F|TMC7_ENST00000304381.5_Missense_Mutation_p.S657F	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	657						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						TCGCTGCAGTCCTTCATCCAT	0.557000													40	89					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98155766	98155766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98155766C>T	ENST00000357947.3	-	12	1621	c.1396G>A	c.(1396-1398)Gga>Aga	p.G466R	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	466	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TTCATGTCTCCCCCGCAGGTA	0.537000											OREG0020398	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	79					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711094	58711094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58711094G>A	ENST00000300079.5	+	2	153	c.103G>A	c.(103-105)Gat>Aat	p.D35N	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_5'UTR	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	gtacctgcaggatccaattgt	0.473000													14	43					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114274902	114274902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114274902G>A	ENST00000357077.4	+	38	5181	c.5128G>A	c.(5128-5130)Gaa>Aaa	p.E1710K	ANK2_ENST00000264366.6_Missense_Mutation_p.E1677K|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1677					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAAATTAAAAGAAAAGCAGAA	0.398000													23	166					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179432393	179432393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179432393C>T	ENST00000589042.1	-	326	78690	c.78466G>A	c.(78466-78468)Gat>Aat	p.D26156N	TTN_ENST00000342992.6_Missense_Mutation_p.D23588N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D17091N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D17283N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D17216N|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D24515N|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24515	Fibronectin type-III 90.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTTTGATCTTCAGTAAGA	0.398000													20	50					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83817025	83817025	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:83817025C>T	ENST00000566620.1	+	13	2372	c.2082C>T	c.(2080-2082)gcC>gcT	p.A694A	CDH13_ENST00000428848.3_Silent_p.A655A|CDH13_ENST00000268613.10_Silent_p.A741A	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	694	Cadherin 5.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CGGCAGGGGCCCTGCGCTTCA	0.517000													7	68					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73836847	73836847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73836847G>A	ENST00000207549.4	-	8	1058	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C	UNC13D_ENST00000587504.1_5'UTR|UNC13D_ENST00000412096.2_Missense_Mutation_p.R227C	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	227					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGAACCTGCGAAGCCCATGC	0.597000									Familial Hemophagocytic Lymphohistiocytosis				40	134					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122854194	122854194	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122854194G>A	ENST00000379645.3	-	2	292	c.219C>T	c.(217-219)tcC>tcT	p.S73S	TRPC3_ENST00000264811.5_5'UTR	NM_001130698.1	NP_001124170.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	0					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TTCCCTCCATGGACCTAATCA	0.547000													6	46					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156283289	156283289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156283289G>A	ENST00000311277.4	-	6	976	c.713C>T	c.(712-714)tCa>tTa	p.S238L	AC097467.2_ENST00000600928.1_RNA|AC097467.2_ENST00000594666.1_RNA|AC097467.2_ENST00000596165.1_RNA|AC097467.2_ENST00000597831.1_RNA|MAP9_ENST00000515654.1_Missense_Mutation_p.S238L|AC097467.2_ENST00000594492.1_RNA|AC097467.2_ENST00000598890.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	238					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TGTTAAGCATGAATCCTGTTT	0.318000													26	59					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48762084	48762084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48762084C>T	ENST00000285238.8	+	29	4208	c.4128C>T	c.(4126-4128)ttC>ttT	p.F1376F		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1376	ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCATCCTGTTCTCGGGGACCC	0.602000													25	90					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17419886	17419886	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17419886C>T	ENST00000302539.4	-	30	3881	c.3756_splice	c.e30+1	p.M1252_splice	ABCC8_ENST00000389817.3_Splice_Site_p.M1251_splice	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1251	ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TAGCACTTGCCATTCGGACTT	0.542000													11	44					0	0	1	0	0
RHOD	29984	broad.mit.edu	37	11	66834233	66834233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66834233G>A	ENST00000308831.2	+	3	330	c.245G>A	c.(244-246)cGg>cAg	p.R82Q	RHOD_ENST00000532559.1_Intron|RHOD_ENST00000533360.1_Missense_Mutation_p.R82Q	NM_014578.3	NP_055393.1	O00212	RHOD_HUMAN	ras homolog family member D	82					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			lung(3)	3						GACCGCCTGCGGCCCCTGTTC	0.607000													76	126					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131733085	131733085	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131733085C>T	ENST00000372577.2	+	11	982	c.961C>T	c.(961-963)Cca>Tca	p.P321S		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	321					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						ACATCATGCCCCAGTGCTTTT	0.483000													27	79					0	0	1	0	0
OR5K3	403277	broad.mit.edu	37	3	98110041	98110041	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98110041T>A	ENST00000383695.1	+	1	532	c.532T>A	c.(532-534)Ttc>Atc	p.F178I	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005516.1	NP_001005516.1	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K, member 3	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|prostate(1)|skin(1)|urinary_tract(1)	27						CAATCATTTTTTCTGTGATGT	0.363000													33	93					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179561838	179561838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179561838G>A	ENST00000444136.1	+	2	338	c.88G>A	c.(88-90)Gag>Aag	p.E30K	TDRD5_ENST00000367614.1_Missense_Mutation_p.E30K|TDRD5_ENST00000294848.8_Missense_Mutation_p.E30K	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	30	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GAGCCCACAGGAGTTGGAGAA	0.483000													41	126					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43778950	43778950	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43778950G>A	ENST00000405006.4	-	19	3276	c.2925C>T	c.(2923-2925)ctC>ctT	p.L975L	THADA_ENST00000405975.2_Silent_p.L975L|THADA_ENST00000330266.7_Silent_p.L685L|THADA_ENST00000415080.2_Silent_p.L685L	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	975							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CCATTGGGATGAGGCCTTCAG	0.468000													12	57					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78846279	78846279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:78846279G>A	ENST00000286627.5	-	11	2359	c.1407C>T	c.(1405-1407)tcC>tcT	p.S469S	KCNMA1_ENST00000404857.1_Silent_p.S469S|KCNMA1_ENST00000372443.1_Silent_p.S469S|KCNMA1_ENST00000286628.8_Silent_p.S469S|KCNMA1_ENST00000372440.1_Silent_p.S469S|KCNMA1_ENST00000354353.5_Silent_p.S469S|KCNMA1_ENST00000406533.3_Silent_p.S469S|KCNMA1_ENST00000404771.3_Silent_p.S469S	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	469	RCK N-terminal.				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GATTGAGGACGGAACCCTGAT	0.478000													20	56					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46797136	46797136	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46797136G>T	ENST00000230588.4	+	10	981	c.972G>T	c.(970-972)gcG>gcT	p.A324A		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	324	MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			CGGGGTCCGCGGAAGAGGCAG	0.537000													37	136					1.30998e-17	1.31762e-17	1	1	0
SEMA6B	10501	broad.mit.edu	37	19	4544371	4544371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4544371C>T	ENST00000586582.1	-	17	2219	c.1909G>A	c.(1909-1911)Gag>Aag	p.E637K	SEMA6B_ENST00000586965.1_Intron|SEMA6B_ENST00000301293.3_Missense_Mutation_p.E637K	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	637					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGATGGCCTCCTTGTCCTTG	0.776000													6	9					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126398443	126398443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126398443C>T	ENST00000394329.3	+	13	12440	c.12427C>T	c.(12427-12429)Cct>Tct	p.P4143S	FAT4_ENST00000335110.5_Missense_Mutation_p.P2406S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4143	Laminin G-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAATGGAAGGCCTCTGGAACC	0.413000													52	139					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53223903	53223903	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53223903C>T	ENST00000330553.5	-	4	794		c.e4-1			NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79							keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CATCCACATCCTGGGGACGAG	0.582000													19	51					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203420441	203420441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:203420441C>T	ENST00000374580.4	+	12	2592	c.2053C>T	c.(2053-2055)Ctc>Ttc	p.L685F	BMPR2_ENST00000374574.2_Intron	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	685					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						TGATGAGAATCTCATGGAGCA	0.448000													18	81					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159860290	159860290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159860290C>T	ENST00000368099.4	-	3	316	c.252G>A	c.(250-252)cgG>cgA	p.R84R	CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000426543.2_5'UTR	NM_012337.2	NP_036469.2	Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	84						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			GGACCATGTCCCGGGTGATGA	0.522000													18	129					0	0	1	0	0
SLC25A40	55972	broad.mit.edu	37	7	87487997	87487997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87487997G>A	ENST00000341119.5	-	3	392	c.46C>T	c.(46-48)Ctt>Ttt	p.L16F		NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40	16					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					ATTTGTTGAAGAGGTGTCACT	0.323000													18	49					0	0	1	0	0
BRCA1	672	broad.mit.edu	37	17	41246011	41246011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:41246011G>A	ENST00000309486.4	-	9	1676	c.649C>T	c.(649-651)Cat>Tat	p.H217Y	BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000346315.3_Missense_Mutation_p.H513Y|BRCA1_ENST00000354071.3_Missense_Mutation_p.H513Y|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000493795.1_Missense_Mutation_p.H466Y|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000357654.3_Missense_Mutation_p.H513Y|BRCA1_ENST00000471181.2_Missense_Mutation_p.H513Y	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	513					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCCTCAGGATGAAGGCCTGAT	0.388000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			13	29					0	0	1	0	0
FAS	355	broad.mit.edu	37	10	90762815	90762815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90762815C>T	ENST00000355740.2	+	2	280	c.60C>T	c.(58-60)tcC>tcT	p.S20S	FAS_ENST00000352159.4_Silent_p.S20S|FAS_ENST00000313771.5_3'UTR|FAS_ENST00000357339.2_Silent_p.S20S|FAS_ENST00000355279.2_Silent_p.S20S	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	20					activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		GATTATCGTCCAAAAGTGTTA	0.398000													24	66					0	0	1	0	0
PREB	10113	broad.mit.edu	37	2	27354630	27354630	+	Missense_Mutation	SNP	G	G	A	rs150589957	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27354630G>A	ENST00000260643.2	-	8	1322	c.1069C>T	c.(1069-1071)Cgt>Tgt	p.R357C	PREB_ENST00000406567.3_Missense_Mutation_p.R299C	NM_013388.4	NP_037520.1	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding	357					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGGACCACGACCCTTCTCA	0.567000													68	168					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952828	119952828	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119952828G>A	ENST00000307142.4	+	4	3094	c.2898G>A	c.(2896-2898)aaG>aaA	p.K966K	SYNPO2_ENST00000434046.2_Silent_p.K966K|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Silent_p.K966K	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	966						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ATGTCATGAAGCACCAACCGT	0.498000													19	58					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743479	81743479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81743479C>T	ENST00000555447.1	-	6	2588	c.2176G>A	c.(2176-2178)Gag>Aag	p.E726K	STON2_ENST00000267540.2_Missense_Mutation_p.E726K	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	726	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		ATCACATTCTCACAGGGAACC	0.552000													64	145					0	0	1	0	0
LINC00303	284573	broad.mit.edu	37	1	204006418	204006418	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204006418G>A	ENST00000367207.3	-	0	602																											GTGAACTTGGGGCACTGGAAA	0.502000													3	8					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170115597	170115597	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170115597C>T	ENST00000263816.3	-	17	2736	c.2451G>A	c.(2449-2451)acG>acA	p.T817T	LRP2_ENST00000443831.1_Silent_p.T680T	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	817					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGTGCGTCTCGTTTTATCAG	0.393000													64	138					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216062391	216062391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216062391C>T	ENST00000366943.2	-	41	7986	c.7600G>A	c.(7600-7602)Gga>Aga	p.G2534R	USH2A_ENST00000307340.3_Missense_Mutation_p.G2534R|RP5-1111A8.3_ENST00000414995.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2534	Fibronectin type-III 12.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACTACAGGTCCAGGTTCTGTA	0.413000										HNSCC(13;0.011)			17	53					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77347614	77347614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77347614G>A	ENST00000451710.3	-	36	6064	c.5827C>T	c.(5827-5829)Cct>Tct	p.P1943S	TRPM6_ENST00000449912.2_Missense_Mutation_p.P1934S|TRPM6_ENST00000360774.1_Missense_Mutation_p.P1939S|TRPM6_ENST00000376871.3_Missense_Mutation_p.P776S|TRPM6_ENST00000361255.3_Missense_Mutation_p.P1934S|TRPM6_ENST00000376872.3_Missense_Mutation_p.P894S			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1939	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TTGACTTCAGGTTTTATAACA	0.254000													8	36					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580591	140580591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580591C>T	ENST00000354757.3	+	1	1244	c.1244C>T	c.(1243-1245)gCc>gTc	p.A415V	PCDHB11_ENST00000536699.1_Missense_Mutation_p.A50V	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		415	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGAGCACAGCCGAGTACAAT	0.493000													31	127					0	0	1	0	0
IL15RA	3601	broad.mit.edu	37	10	6002493	6002493	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6002493C>T	ENST00000525219.2	-	4	606	c.312G>A	c.(310-312)gcG>gcA	p.A104A	IL15RA_ENST00000397250.2_Silent_p.A42A|IL15RA_ENST00000528354.1_Silent_p.A107A|IL15RA_ENST00000397251.3_Silent_p.A75A|IL15RA_ENST00000397248.2_Silent_p.A104A|IL15RA_ENST00000379971.1_Silent_p.A42A|IL15RA_ENST00000379977.3_Silent_p.A140A|IL15RA_ENST00000530685.1_Silent_p.A107A|IL15RA_ENST00000397255.3_Silent_p.A140A|IL15RA_ENST00000534292.1_5'UTR	NM_001243539.1	NP_001230468.1	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha	140					cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5						CTGTTGTGGCCGCTGTGTTGT	0.567000													19	38					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74536434	74536434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74536434G>A	ENST00000321288.5	+	4	739	c.739G>A	c.(739-741)Gct>Act	p.A247T	CCDC33_ENST00000398814.3_Missense_Mutation_p.A44T			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	247	C2.						protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CCTCCATGGGGCTACCAACCT	0.617000													19	101					0	0	1	0	0
C3orf56	285311	broad.mit.edu	37	3	126916055	126916055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126916055G>A	ENST00000398112.1	+	2	767	c.527G>A	c.(526-528)gGa>gAa	p.G176E		NM_001007534.2	NP_001007535.1			chromosome 3 open reading frame 56											breast(1)|endometrium(2)|kidney(1)|lung(5)	9				GBM - Glioblastoma multiforme(114;0.142)		CCATCCAGAGGAGCTCCCTAC	0.647000													24	47					0	0	1	0	0
CRYBB2	1415	broad.mit.edu	37	22	25627729	25627729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25627729C>T	ENST00000398215.2	+	6	779	c.608C>T	c.(607-609)cCc>cTc	p.P203L		NM_000496.2	NP_000487.1	P43320	CRBB2_HUMAN	crystallin, beta B2	203	C-terminal arm.				response to stimulus|visual perception		structural constituent of eye lens			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	10						GCCTTCCACCCCTCCAACTAG	0.622000													24	66					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	19018322	19018322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19018322C>T	ENST00000420770.2	+	5	744	c.661C>T	c.(661-663)Cgg>Tgg	p.R221W	PAX7_ENST00000400661.3_Missense_Mutation_p.R219W|PAX7_ENST00000375375.3_Missense_Mutation_p.R221W	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	221					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		GCGACGCAGTCGGACCACATT	0.637000			T	FOXO1A	alveolar rhabdomyosarcoma								7	18					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533142	169533142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169533142C>T	ENST00000449804.2	+	1	226	c.181C>T	c.(181-183)Ccc>Tcc	p.P61S	FOXI1_ENST00000306268.6_Missense_Mutation_p.P61S	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	61	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CACCCCCAACCCCTACCTCTG	0.677000									Pendred syndrome				7	22					0	0	1	0	0
POU3F4	5456	broad.mit.edu	37	X	82763827	82763827	+	Silent	SNP	G	G	T	rs56143048		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:82763827G>T	ENST00000373200.2	+	1	559	c.495G>T	c.(493-495)gtG>gtT	p.V165V	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	165					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						TGCACCCGGTGCTCCGAGAGC	0.647000													6	4					0.00116845	0.00116969	1	1	0
CABP2	51475	broad.mit.edu	37	11	67288529	67288529	+	Missense_Mutation	SNP	C	C	T	rs140767804	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67288529C>T	ENST00000294288.4	-	4	415	c.346G>A	c.(346-348)Gag>Aag	p.E116K	CABP2_ENST00000353903.5_Missense_Mutation_p.E59K	NM_016366.2	NP_057450.2	Q9NPB3	CABP2_HUMAN	calcium binding protein 2	116	EF-hand 2.				signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	9						AGCTCCATCTCGGTGGGCATG	0.627000													44	89					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511288	61511288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61511288G>A	ENST00000266070.4	-	16	6345	c.6020C>T	c.(6019-6021)tCg>tTg	p.S2007L	DIDO1_ENST00000395343.1_Missense_Mutation_p.S2007L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	2007	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GTGAAATCGCGAAGGGGTCTG	0.632000													14	191					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3000169	3000169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3000169G>A	ENST00000520002.1	-	42	6617	c.6062C>T	c.(6061-6063)tCt>tTt	p.S2021F	CSMD1_ENST00000542608.1_Missense_Mutation_p.S2020F|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000539096.1_Missense_Mutation_p.S2020F|CSMD1_ENST00000537824.1_Missense_Mutation_p.S2020F|CSMD1_ENST00000602723.1_Missense_Mutation_p.S2021F|CSMD1_ENST00000400186.3_Missense_Mutation_p.S2021F|CSMD1_ENST00000602557.1_Missense_Mutation_p.S2021F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2021	CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGCTTCGGTAGAAAAATTCAG	0.398000													31	112					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72338444	72338444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:72338444C>T	ENST00000340595.3	+	11	1724	c.1528C>T	c.(1528-1530)Cgc>Tgc	p.R510C	SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000264485.5_Missense_Mutation_p.R554C|SLC4A4_ENST00000425175.1_Missense_Mutation_p.R554C|SLC4A4_ENST00000351898.6_Missense_Mutation_p.R554C|SLC4A4_ENST00000512686.1_Missense_Mutation_p.R510C	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	554						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TTTGGAGTTTCGCCTTTGGAT	0.408000													94	223					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97051876	97051876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:97051876G>A	ENST00000524981.3	+	4	670	c.670G>A	c.(670-672)Gtt>Att	p.V224I				Q6ZTY8	CL063_HUMAN		198										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GTTCAATACAGTTTCACAGTA	0.294000													17	52					0	0	1	0	0
IKBKE	9641	broad.mit.edu	37	1	206666435	206666435	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206666435C>T	ENST00000367120.3	+	19	2288	c.1915C>T	c.(1915-1917)Cag>Tag	p.Q639*	C1orf147_ENST00000367119.1_Intron|IKBKE_ENST00000462698.1_3'UTR|IKBKE_ENST00000537984.1_Nonsense_Mutation_p.Q554*	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	639					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					CCAGGGGGTCCAGGAGAGTCT	0.597000													3	10					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94929538	94929538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94929538G>A	ENST00000337425.5	-	5	1274	c.1200C>T	c.(1198-1200)ccC>ccT	p.P400P	SERPINA9_ENST00000448305.2_Silent_p.P302P|SERPINA9_ENST00000424550.2_Silent_p.P251P|SERPINA9_ENST00000298845.7_Silent_p.P300P|SERPINA9_ENST00000380365.3_Silent_p.P382P|RP11-349I1.2_ENST00000536735.1_RNA	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	382					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		TGAAGTAAGAGGGGCCATCCT	0.498000													29	108					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44234858	44234858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44234858G>A	ENST00000330884.4	-	4	517	c.397C>T	c.(397-399)Cgc>Tgc	p.R133C	SULT4A1_ENST00000249130.5_Missense_Mutation_p.R133C|SULT4A1_ENST00000540422.1_Intron	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	133					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		TTGGGGTTGCGAGCCATATAG	0.572000													21	57					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119124924	119124924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119124924C>T	ENST00000328252.3	+	18	4770	c.4401C>T	c.(4399-4401)tcC>tcT	p.S1467S	PAPPA_ENST00000534838.1_Silent_p.S505S	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1467	Sushi 4.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GGAACGGCTCCTTCCATGTCT	0.532000													26	67					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32751281	32751281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32751281C>T	ENST00000333070.4	+	13	1684	c.1584C>T	c.(1582-1584)ttC>ttT	p.F528F	LCK_ENST00000336890.5_Silent_p.F498F|LCK_ENST00000373564.3_Silent_p.F505F	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	498					activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	AGGACTTCTTCACGGCCACAG	0.612000			T	TRB@	T-ALL								9	20					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103427784	103427784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103427784C>T	ENST00000358392.2	-	40	3415	c.3098G>A	c.(3097-3099)gGa>gAa	p.G1033E	COL11A1_ENST00000370096.3_Missense_Mutation_p.G1021E|COL11A1_ENST00000512756.1_Missense_Mutation_p.G905E|COL11A1_ENST00000353414.4_Missense_Mutation_p.G982E	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1021	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCCTGCTGGTCCATCTTTCCC	0.378000													18	103					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87772364	87772364	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87772364C>T	ENST00000398204.4	+	15	1567	c.1244C>T	c.(1243-1245)aCc>aTc	p.T415I	ADAM22_ENST00000398209.3_Missense_Mutation_p.T415I|ADAM22_ENST00000265727.7_Missense_Mutation_p.T415I|ADAM22_ENST00000398201.4_Missense_Mutation_p.T415I|ADAM22_ENST00000315984.7_Missense_Mutation_p.T415I	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	415	Peptidase M12B.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			AAAAAGTTCACCCAGTGTAAT	0.358000													32	127					0	0	1	0	0
LRRN4	164312	broad.mit.edu	37	20	6022607	6022607	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6022607C>T	ENST00000378858.4	-	5	1508	c.1284G>A	c.(1282-1284)ggG>ggA	p.G428G		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	428						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						AGGGGGCAGTCCCCTCCCGTG	0.657000													20	41					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32362678	32362678	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32362678C>T	ENST00000454136.3	-	6	1207	c.1203G>A	c.(1201-1203)acG>acA	p.T401T	BTNL2_ENST00000414363.1_Silent_p.T191T|BTNL2_ENST00000540315.1_Silent_p.T191T|BTNL2_ENST00000374993.1_Silent_p.T401T|BTNL2_ENST00000429232.2_3'UTR|BTNL2_ENST00000374995.3_Silent_p.T307T|BTNL2_ENST00000544175.1_Silent_p.T124T			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	401						integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						ATGATGGTATCGTCTTTCCTT	0.562000													25	191					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32774912	32774912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:32774912G>A	ENST00000265074.8	+	4	1501	c.1158G>A	c.(1156-1158)ggG>ggA	p.G386G	NPR3_ENST00000415685.2_Silent_p.G170G|NPR3_ENST00000434067.2_Silent_p.G170G|NPR3_ENST00000415167.2_Silent_p.G386G	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	386					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	AGGATGGAGGGAAAATTATAC	0.443000													62	114					0	0	1	0	0
MAN1C1	57134	broad.mit.edu	37	1	26012982	26012982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26012982G>A	ENST00000374332.4	+	2	922	c.592G>A	c.(592-594)Gaa>Aaa	p.E198K	MAN1C1_ENST00000263979.3_Missense_Mutation_p.E18K	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	198					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	p.E198K(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GGGGAAAAACGAACTCCGTCC	0.498000													59	141					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35224069	35224069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:35224069G>A	ENST00000360310.1	-	26	5005	c.4438C>T	c.(4438-4440)Cgt>Tgt	p.R1480C	BAZ1A_ENST00000382422.2_Missense_Mutation_p.R1480C|BAZ1A_ENST00000358716.4_Missense_Mutation_p.R1448C	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1480	Bromo.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		ACTTTTTCACGAATTATATTT	0.284000													19	39					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90503636	90503636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90503636C>T	ENST00000325643.5	+	4	4300	c.4234C>T	c.(4234-4236)Cca>Tca	p.P1412S		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCCTGTGTCCCCAGCTGGTCC	0.627000													18	38					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89266222	89266222	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89266222G>A	ENST00000464162.1	-	0	64																											AGAGCAGCAGGAGCCCCAGGA	0.557000													54	179					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22783059	22783059	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22783059G>A	ENST00000600260.1	+	0	566					NR_033899.1																						GGAGGAGCTGGAGAGTCTGGC	0.632000													3	8					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109730818	109730818	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109730818G>A	ENST00000369939.3	+	9	1244	c.1061G>A	c.(1060-1062)tGg>tAg	p.W354*	KIAA1324_ENST00000529753.1_Nonsense_Mutation_p.W267*|KIAA1324_ENST00000369938.1_3'UTR	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	354					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		ATGTACAAATGGGCCAAGCCG	0.532000													33	90					0	0	1	0	0
TMEM151A	256472	broad.mit.edu	37	11	66062685	66062685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66062685C>T	ENST00000327259.4	+	2	1112	c.968C>T	c.(967-969)tCg>tTg	p.S323L		NM_153266.3	NP_694998.1	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	323						integral to membrane				central_nervous_system(1)|kidney(4)|lung(6)	11						GGCGCCAGCTcgcccccgccg	0.716000													5	11					0	0	1	0	0
CBR3-AS1	100506428	broad.mit.edu	37	21	37504920	37504920	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37504920G>A	ENST00000413862.1	-	0	706				CBR3-AS1_ENST00000453159.1_RNA	NR_038892.1																						AAGGCCGCCCGGGAGCTGCTG	0.567000													4	12					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26115882	26115882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26115882C>T	ENST00000313735.6	-	4	504	c.271G>A	c.(271-273)Ggc>Agc	p.G91S		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	91					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	ATCCCGCTGCCCCAGTTTTTG	0.527000													61	74					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2786979	2786979	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2786979G>A	ENST00000399655.1	+	41	5302	c.5037G>A	c.(5035-5037)ctG>ctA	p.L1679L	CACNA1C_ENST00000399637.1_Silent_p.L1698L|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000335762.5_Silent_p.L1704L|CACNA1C_ENST00000399603.1_Silent_p.L1679L|CACNA1C_ENST00000399649.1_Silent_p.L1685L|CACNA1C_ENST00000399595.1_Silent_p.L1687L|CACNA1C_ENST00000399606.1_Silent_p.L1699L|CACNA1C_ENST00000399601.1_Silent_p.L1679L|CACNA1C_ENST00000399617.1_Silent_p.L1679L|CACNA1C_ENST00000344100.3_Silent_p.L1720L|CACNA1C_ENST00000399621.1_Silent_p.L1698L|CACNA1C_ENST00000399629.1_Silent_p.L1696L|CACNA1C_ENST00000327702.7_Silent_p.L1679L|CACNA1C_ENST00000406454.3_Silent_p.L1679L|CACNA1C_ENST00000402845.3_Silent_p.L1698L|CACNA1C_ENST00000399597.1_Silent_p.L1679L|CACNA1C_ENST00000347598.4_Silent_p.L1727L|CACNA1C_ENST00000399641.1_Silent_p.L1679L|CACNA1C_ENST00000399638.1_Silent_p.L1707L|CACNA1C_ENST00000399644.1_Silent_p.L1679L|CACNA1C_ENST00000399591.1_Silent_p.L1687L|CACNA1C_ENST00000399634.1_Silent_p.L1679L	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1727					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGGAGGAGCTGGACAAGGCCA	0.577000													16	45					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179567368	179567368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179567368C>T	ENST00000589042.1	-	107	30470	c.30246G>A	c.(30244-30246)aaG>aaA	p.K10082K	TTN_ENST00000342992.6_Silent_p.K8838K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.K9765K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9765	Glu-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGTATGCGCTTTGTAAACT	0.393000													16	51					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170729	207170729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207170729G>A	ENST00000374423.3	+	5	1863	c.1477G>A	c.(1477-1479)Gaa>Aaa	p.E493K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	493							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TAGTAGTTCTGAAACGAATTT	0.393000													12	51					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172737294	172737294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172737294C>T	ENST00000351008.3	-	4	1013	c.830G>A	c.(829-831)aGg>aAg	p.R277K		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	277					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTCTGAATACCTCTCCAGACA	0.348000													37	163					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220333881	220333881	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220333881G>A	ENST00000312358.7	+	13	3627	c.3495G>A	c.(3493-3495)tcG>tcA	p.S1165S	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1165					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTTGCAGCTCGAAGCTGGAGA	0.667000													8	15					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8181439	8181439	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:8181439G>A	ENST00000402384.3	-	10	1177	c.911C>T	c.(910-912)tCa>tTa	p.S304L	ICA1_ENST00000406470.2_Missense_Mutation_p.S304L|ICA1_ENST00000265577.7_Missense_Mutation_p.S303L|ICA1_ENST00000396675.3_Missense_Mutation_p.S304L|ICA1_ENST00000422063.2_Missense_Mutation_p.S333L|ICA1_ENST00000401396.1_Missense_Mutation_p.S292L			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	304					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TTCCTCTAATGAAATTAATCT	0.279000													3	22					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50209536	50209536	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50209536G>A	ENST00000392518.4	+	12	1581	c.1209G>A	c.(1207-1209)gaG>gaA	p.E403E	CPT1C_ENST00000323446.5_Silent_p.E403E|CPT1C_ENST00000598293.1_Silent_p.E403E|CPT1C_ENST00000354199.5_Silent_p.E403E|CPT1C_ENST00000405931.2_Silent_p.E392E	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	403					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		AGGCAGCGGAGGCCCTGGAGG	0.701000													5	23					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228467761	228467761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228467761C>T	ENST00000570156.2	+	33	8997	c.8923C>T	c.(8923-8925)Cac>Tac	p.H2975Y	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.H2546Y|OBSCN_ENST00000359599.6_Missense_Mutation_p.H1393Y|OBSCN_ENST00000284548.11_Missense_Mutation_p.H2546Y|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1976	Ig-like 29.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGCAGTGCCCACAGCAGCAC	0.617000													5	13					0	0	1	0	0
ZBED6CL	113763	broad.mit.edu	37	7	150027920	150027920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150027920G>A	ENST00000343855.4	+	1	983	c.427G>A	c.(427-429)Gag>Aag	p.E143K	LRRC61_ENST00000323078.7_Intron|LRRC61_ENST00000493307.1_Intron|LRRC61_ENST00000359623.4_Intron	NM_138434.2	NP_612443.1			ZBED6 C-terminal like																		CTCCGGGGTGGAGGGGAGAAG	0.632000													12	34					0	0	1	0	0
WDR89	112840	broad.mit.edu	37	14	64066611	64066611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:64066611G>A	ENST00000394942.2	-	2	138	c.50C>T	c.(49-51)tCc>tTc	p.S17F	WDR89_ENST00000267522.3_Missense_Mutation_p.S17F	NM_001008726.2|NM_001258272.1|NM_080666.3	NP_001008726.1|NP_001245201.1|NP_542397.1	Q96FK6	WDR89_HUMAN	WD repeat domain 89	17										endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.00543)|all cancers(60;0.0181)|BRCA - Breast invasive adenocarcinoma(234;0.101)		GGTTCCTAAGGAACATTTAAC	0.363000													8	117					0	0	1	0	0
SVOP	55530	broad.mit.edu	37	12	109309618	109309618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109309618G>A	ENST00000299134.5	-	13	1184	c.1185C>T	c.(1183-1185)gcC>gcT	p.A395A		NM_018711.2	NP_061181.1	Q8N4V2	SVOP_HUMAN	SV2 related protein homolog (rat)	0						cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity			breast(2)|lung(4)	6						CAGGTGCCCAGGCCGAGGGCC	0.622000													3	20					0	0	1	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19362866	19362866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:19362866C>T	ENST00000454498.2	-	4	1493	c.480G>A	c.(478-480)gaG>gaA	p.E160E	CSGALNACT1_ENST00000522854.1_Silent_p.E160E|CSGALNACT1_ENST00000311540.4_Silent_p.E160E|CSGALNACT1_ENST00000332246.6_Silent_p.E160E|CSGALNACT1_ENST00000544602.1_Silent_p.E160E	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	160					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		TAAGGCCAGTCTCCAGCTGGT	0.557000													29	37					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238045826	238045826	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:238045826G>A	ENST00000366570.4	-	12	1677	c.1519C>T	c.(1519-1521)Ctg>Ttg	p.L507L	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	507					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GCCACCCACAGAACTTTCGAG	0.463000													34	101					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148601507	148601507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:148601507G>A	ENST00000296046.3	+	9	938	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	296					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CCACCTGAATGAAATCAAGGT	0.443000													34	77					0	0	1	0	0
MIR124-2HG	100130155	broad.mit.edu	37	8	65291793	65291793	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:65291793G>A	ENST00000521441.1	+	0	655				MIR124-2_ENST00000385081.1_RNA																							TGCCAAGAGCGGAGCCTACGG	0.478000													11	23					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140183064	140183064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140183064G>A	ENST00000522353.2	+	1	2282	c.2282G>A	c.(2281-2283)gGa>gAa	p.G761E	PCDHA3_ENST00000532566.2_Missense_Mutation_p.G761E|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGTGCTCTGGAGAGGGGTTG	0.607000													33	108					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84700164	84700164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84700164C>T	ENST00000286744.5	+	28	4958	c.4734C>T	c.(4732-4734)tcC>tcT	p.S1578S	ADAMTSL3_ENST00000567476.1_Silent_p.S1578S	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1578						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCTCTGACTCCAACTGTGATG	0.512000													54	220					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610124	47610124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47610124C>T	ENST00000371891.3	+	7	917	c.886C>T	c.(886-888)Ctc>Ttc	p.L296F	CYP4A22_ENST00000485117.1_3'UTR|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000371890.3_Missense_Mutation_p.P244L|CYP4A22_ENST00000294337.3_Missense_Mutation_p.L296F	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	296						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GGACATCCTCCTCTTGGCCAA	0.507000													35	103					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108690226	108690226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108690226G>A	ENST00000232603.5	-	25	2583	c.2501C>T	c.(2500-2502)cCt>cTt	p.P834L	MORC1_ENST00000483760.1_Missense_Mutation_p.P813L	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	834					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						CTGATGCTCAGGAAAAAAATA	0.408000													24	69					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101816796	101816796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101816796C>T	ENST00000370418.3	-	6	1236	c.985G>A	c.(985-987)Gaa>Aaa	p.E329K		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	329	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		ATTAGGGCTTCCCGATTACCC	0.463000													82	252					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55955574	55955574	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55955574C>T	ENST00000263923.4	-	25	3666	c.3371G>A	c.(3370-3372)aGa>aAa	p.R1124K	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1124	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GGCCCTCATTCTAGTTCCTTC	0.398000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			21	44					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111979231	111979231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111979231G>A	ENST00000374566.3	-	16	2121	c.1604C>T	c.(1603-1605)tCc>tTc	p.S535F		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	535						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGAGTTTGGGGACCTCAGAGG	0.582000													44	165					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151784500	151784500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:151784500C>T	ENST00000255262.3	-	1	340	c.175G>A	c.(175-177)Ggg>Agg	p.G59R	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	59					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			CCAATGACCCCCACCACAAAA	0.577000													22	66					0	0	1	0	0
C6orf222	389384	broad.mit.edu	37	6	36287141	36287141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36287141C>T	ENST00000437635.2	-	11	2092	c.1915G>A	c.(1915-1917)Gac>Aac	p.D639N		NM_001010903.4	NP_001010903.3	P0C671	CF222_HUMAN	chromosome 6 open reading frame 222	639										breast(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(4)|urinary_tract(4)	26						ACCGGCTGGTCCTCCCTGTAT	0.542000													32	99					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606647	55606647	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55606647G>A	ENST00000378396.1	+	1	420	c.420G>A	c.(418-420)caG>caA	p.Q140Q		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				CCATCTCCCAGAAACTCTGTG	0.463000													39	80					0	0	1	0	0
LCN6	158062	broad.mit.edu	37	9	139641983	139641983	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139641983G>A	ENST00000435202.1	-	2	92	c.93C>T	c.(91-93)gcC>gcT	p.A31A	LCN6_ENST00000341206.4_Silent_p.A41A			P62502	LCN6_HUMAN	lipocalin 6	41					single fertilization	extracellular region	binding			lung(3)|upper_aerodigestive_tract(1)	4	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.32e-06)|Epithelial(140;7.83e-05)		TTTCCCGGGAGGCCACCGCAA	0.637000													16	48					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115221019	115221019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115221019C>T	ENST00000369538.3	-	7	1161	c.1114G>A	c.(1114-1116)Gaa>Aaa	p.E372K	AMPD1_ENST00000353928.6_Missense_Mutation_p.E343K|AMPD1_ENST00000520113.2_Missense_Mutation_p.E376K	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	343					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	GCAAAAAGTTCCTTTAGGGTC	0.378000													50	118					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117403124	117403124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117403124G>A	ENST00000321322.6	-	4	806	c.805C>T	c.(805-807)Cgg>Tgg	p.R269W	DSCAML1_ENST00000527706.1_Intron	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	209	Ig-like C2-type 3.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TTGCTCTGCCGGGTCTCCCCG	0.617000													9	75					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61559014	61559014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61559014G>A	ENST00000290866.4	+	7	1057	c.1033G>A	c.(1033-1035)Ggg>Agg	p.G345R	ACE_ENST00000538928.1_Missense_Mutation_p.G345R|ACE_ENST00000428043.1_Missense_Mutation_p.G345R|ACE_ENST00000584529.1_3'UTR	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	345	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GTTCTGGGAAGGGTCGATGCT	0.622000													34	50					0	0	1	0	0
OR2T5	401993	broad.mit.edu	37	1	248651978	248651978	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248651978T>C	ENST00000366473.2	+	1	94	c.89T>C	c.(88-90)cTa>cCa	p.L30P		NM_001004697.1	NP_001004697.1	Q6IEZ7	OR2T5_HUMAN	olfactory receptor, family 2, subfamily T, member 5	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(2)|pancreas(1)|skin(2)	9	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CATCCAGCTCTACTTAGTGTG	0.502000													10	183					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1963716	1963716	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1963716C>T	ENST00000217305.2	-	3	240	c.15G>A	c.(13-15)ggG>ggA	p.G5G	PDYN_ENST00000540134.1_Silent_p.G5G|PDYN_ENST00000539905.1_Silent_p.G5G|RP4-684O24.5_ENST00000446562.1_RNA	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	5					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CCAGGACCAGCCCCTGCCAGG	0.567000													8	42					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15654992	15654992	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15654992G>A	ENST00000269703.2	+	10	1237	c.1038G>A	c.(1036-1038)tgG>tgA	p.W346*	CYP4F22_ENST00000601005.2_Nonsense_Mutation_p.W346*	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	346						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						GGATCTCTTGGATGCTGTTCA	0.507000													39	105					0	0	1	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179044567	179044567	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179044567G>A	ENST00000356731.5	-	8	2540	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	HNRNPH1_ENST00000329433.6_Silent_p.F335F|HNRNPH1_ENST00000442819.2_Silent_p.F335F|HNRNPH1_ENST00000393432.4_Silent_p.F335F|HNRNPH1_ENST00000511300.2_Silent_p.F65F|HNRNPH1_ENST00000510411.1_Silent_p.F335F			P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1 (H)	335	2 X 16 AA Gly-rich approximate repeats.|RRM 3.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|skin(1)	14						CATGAGTTGCGAACTCGACAT	0.438000													66	124					0	0	1	0	0
FAM110C	642273	broad.mit.edu	37	2	45946	45946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:45946C>T	ENST00000327669.4	-	1	439	c.440G>A	c.(439-441)gGg>gAg	p.G147E		NM_001077710.2	NP_001071178.2	Q1W6H9	F110C_HUMAN	family with sequence similarity 110, member C	147						microtubule|microtubule organizing center|spindle pole				central_nervous_system(1)|kidney(1)|lung(2)	4	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		CTCCGGGTTCCCGGCCTTGCC	0.756000													7	9					0	0	1	0	0
CT45A5	441521	broad.mit.edu	37	X	134947909	134947909	+	Missense_Mutation	SNP	C	C	T	rs143395460	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:134947909C>T	ENST00000370724.3	-	3	660	c.416G>A	c.(415-417)cGa>cAa	p.R139Q	CT45A5_ENST00000491480.1_Missense_Mutation_p.R139Q|CT45A4_ENST00000420087.2_Intron	NM_001007551.3|NM_001172288.1	NP_001007552.1|NP_001165759.1	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	139								p.R139Q(2)		endometrium(1)|large_intestine(2)|lung(6)	9						CTACTTACTTCGTCCAAGGCA	0.388000													39	26					0	0	1	0	0
SSTR1	6751	broad.mit.edu	37	14	38678933	38678933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:38678933C>T	ENST00000267377.2	+	3	956	c.339C>T	c.(337-339)ttC>ttT	p.F113F		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	113					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GCGTGCCCTTCCTAGTCACCT	0.572000													50	202					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137655578	137655578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137655578G>A	ENST00000371817.3	+	20	2443	c.2029G>A	c.(2029-2031)Gag>Aag	p.E677K		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	677	Triple-helical region.			E -> K (in Ref. 1; BAA14323).|E -> Q (in Ref. 4; AA sequence).	axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GCTGCCTGGGGAGCCCGTAAG	0.592000													10	82					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7151403	7151403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:7151403G>A	ENST00000303635.7	+	4	481	c.274G>A	c.(274-276)Gaa>Aaa	p.E92K	CAMTA1_ENST00000439411.2_Missense_Mutation_p.E92K	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GAAACACGAAGAATGGCTAAC	0.353000			T	WWTR1	epitheliod hemangioendothelioma								27	57					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53619662	53619662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53619662C>T	ENST00000594011.1	-	4	298	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	ZNF415_ENST00000601493.1_Intron|ZNF415_ENST00000599261.1_Missense_Mutation_p.E14K|ZNF415_ENST00000601215.1_Intron|ZNF415_ENST00000595193.1_Missense_Mutation_p.E14K|ZNF415_ENST00000596683.1_5'UTR|ZNF415_ENST00000597748.1_Missense_Mutation_p.E14K|ZNF415_ENST00000600574.1_Missense_Mutation_p.E14K|ZNF415_ENST00000440291.1_5'UTR|ZNF415_ENST00000595813.1_Missense_Mutation_p.E14K|ZNF415_ENST00000597503.1_Missense_Mutation_p.E14K|ZNF415_ENST00000500065.4_Missense_Mutation_p.E14K|ZNF415_ENST00000448501.1_5'UTR|ZNF415_ENST00000421033.1_5'UTR|ZNF415_ENST00000243643.4_Missense_Mutation_p.E14K|ZNF415_ENST00000455735.2_5'UTR			Q09FC8	ZN415_HUMAN	zinc finger protein 415	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		TGAGAGAATTCGATGGCCACG	0.423000													31	141					0	0	1	0	0
WFDC10B	280664	broad.mit.edu	37	20	44333610	44333610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44333610C>T	ENST00000335769.2	-	1	48	c.21G>A	c.(19-21)agG>agA	p.R7R	WFDC13_ENST00000305479.2_Intron|WFDC10B_ENST00000330523.5_5'UTR	NM_172131.2	NP_742143.1	Q8IUB3	WF10B_HUMAN	WAP four-disulfide core domain 10B	0						extracellular region	peptidase inhibitor activity			lung(2)|ovary(1)|stomach(1)	4		Myeloproliferative disorder(115;0.0122)				TTTTGCTTGCCCTCCTTTCAC	0.483000													40	157					0	0	1	0	0
TRAV4	28689	broad.mit.edu	37	14	22205179	22205179	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22205179C>T	ENST00000390426.2	+	0	310																											CCCTGTTTATCCCTGCCGACA	0.498000													17	19					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33463397	33463397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33463397G>A	ENST00000455041.2	-	23	2940	c.2881C>T	c.(2881-2883)Cgc>Tgc	p.R961C	NOL6_ENST00000464829.1_Intron|NOL6_ENST00000379471.2_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	1013					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGAGACAGGCGAATCAGCACG	0.652000													9	33					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38805726	38805726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38805726C>T	ENST00000359357.3	+	31	3977	c.3723C>T	c.(3721-3723)ttC>ttT	p.F1241F	DNAH8_ENST00000449981.2_Silent_p.F1458F|DNAH8_ENST00000441566.1_Silent_p.F1241F					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGGCCAGTTTCGATGATCTGT	0.323000													20	50					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169251	113169251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113169251C>T	ENST00000401783.2	-	38	8965	c.8629G>A	c.(8629-8631)Gga>Aga	p.G2877R	SVEP1_ENST00000374469.1_Missense_Mutation_p.G2854R|SVEP1_ENST00000297826.5_Missense_Mutation_p.G803R	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2877	Sushi 24.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTCCAACTTCCATTGGCAAGA	0.537000													16	46					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29039818	29039818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29039818G>A	ENST00000257189.4	+	6	611	c.528G>A	c.(526-528)gtG>gtA	p.V176V		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	176	Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACTCACTGGTGATGATACTAA	0.353000													17	50					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	145972622	145972622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145972622G>A	ENST00000394413.3	-	8	1534	c.964C>T	c.(964-966)Cat>Tat	p.H322Y	PPP2R2B_ENST00000394411.4_Missense_Mutation_p.H322Y|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.H328Y|PPP2R2B_ENST00000394414.1_Missense_Mutation_p.H388Y|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.H311Y|PPP2R2B_ENST00000356826.3_Missense_Mutation_p.H322Y|PPP2R2B_ENST00000394409.3_Missense_Mutation_p.H380Y|PPP2R2B_ENST00000508545.2_Missense_Mutation_p.H311Y|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.H325Y|PPP2R2B_ENST00000453001.1_Missense_Mutation_p.H322Y|CTB-99A3.1_ENST00000512730.1_RNA			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	322					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGTAGTCATGAACCTGGAGA	0.393000													54	117					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448661	155448661	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155448661G>A	ENST00000368346.3	-	3	4639	c.4000C>T	c.(4000-4002)Ccc>Tcc	p.P1334S	ASH1L_ENST00000392403.3_Missense_Mutation_p.P1334S			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1334					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GGGTCTAAGGGGAAAGAAGGA	0.408000													27	96					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54872761	54872761	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54872761C>T	ENST00000391743.3	-	2	352	c.72G>A	c.(70-72)ggG>ggA	p.G24G	LAIR1_ENST00000391742.2_Silent_p.G42G|LAIR1_ENST00000434277.2_Silent_p.G41G|LAIR1_ENST00000313038.6_Silent_p.G35G|LAIR1_ENST00000348231.4_Silent_p.G42G|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000474878.1_Silent_p.G41G			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	42						integral to membrane|plasma membrane	protein binding|receptor activity	p.G42G(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		TCACATGGCTCCCCAGGGGGA	0.572000													60	150					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	825227	825227	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:825227C>T	ENST00000297440.6	+	13	2525	c.2505C>T	c.(2503-2505)caC>caT	p.H835H	HEATR2_ENST00000403952.3_Silent_p.H260H|HEATR2_ENST00000313147.5_Intron	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	835							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		TCCACAAGCACCGCTCGGCCA	0.602000													32	61					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159548022	159548022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:159548022C>T	ENST00000307765.5	+	10	1057	c.806C>T	c.(805-807)tCc>tTc	p.S269F	RXFP1_ENST00000343542.5_Missense_Mutation_p.S269F|RXFP1_ENST00000460056.2_Missense_Mutation_p.S188F|RXFP1_ENST00000470033.1_Missense_Mutation_p.S236F|RXFP1_ENST00000448688.2_Intron	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	269						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding	p.S269F(2)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		ACTTTTATTTCCTGCAGTAAT	0.269000													10	38					0	0	1	0	0
GREM1	26585	broad.mit.edu	37	15	33023078	33023078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33023078G>A	ENST00000300177.4	+	2	376	c.187G>A	c.(187-189)Ggg>Agg	p.G63R	GREM1_ENST00000560830.1_Intron|GREM1_ENST00000322805.4_Intron|GREM1_ENST00000560677.1_Intron	NM_001191322.1|NM_001191323.1|NM_013372.6	NP_001178251.1|NP_001178252.1|NP_037504.1	O60565	GREM1_HUMAN	gremlin 1, DAN family BMP antagonist	63					negative regulation of BMP signaling pathway|nervous system development|regulation of epithelial to mesenchymal transition	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)	10		all_lung(180;1.49e-09)		all cancers(64;2.97e-18)|Epithelial(43;3.15e-12)|GBM - Glioblastoma multiforme(186;2.32e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0107)		GCGGGGCCAAGGGCGGGGCAC	0.662000													11	49					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89827573	89827573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89827573C>T	ENST00000264344.5	-	6	1007	c.800G>A	c.(799-801)aGa>aAa	p.R267K	FAM13A_ENST00000511976.1_Missense_Mutation_p.R58K|FAM13A_ENST00000502459.1_5'UTR	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	267					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TTCTAAGCCTCTTGTTAAAAG	0.368000													167	417					0	0	1	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67174477	67174477	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67174477C>T	ENST00000312390.5	+	8	857	c.828C>T	c.(826-828)ttC>ttT	p.F276F	TBC1D10C_ENST00000542590.1_Silent_p.F276F|TBC1D10C_ENST00000526387.1_Intron	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	276	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GGGATGCCTTCCTCAGTGAGG	0.662000													48	120					0	0	1	0	0
MAPK1	5594	broad.mit.edu	37	22	22123583	22123583	+	Silent	SNP	G	G	A	rs62235129		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22123583G>A	ENST00000215832.6	-	8	1181	c.993C>T	c.(991-993)ttC>ttT	p.F331F	MAPK1_ENST00000491588.1_5'UTR|MAPK1_ENST00000544786.1_Silent_p.F287F|MAPK1_ENST00000398822.3_Silent_p.F331F	NM_002745.4	NP_002736.3	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	331					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	ATTCCATGTCGAACTTGAATG	0.368000													32	60					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31816128	31816128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:31816128G>A	ENST00000446923.2	+	9	3654	c.3263G>A	c.(3262-3264)aGc>aAc	p.S1088N	ZEB1_ENST00000361642.5_Missense_Mutation_p.S1105N|ZEB1_ENST00000542815.3_Missense_Mutation_p.S1037N|ZEB1_ENST00000320985.10_Missense_Mutation_p.S1104N|ZEB1_ENST00000560721.2_Missense_Mutation_p.S1084N	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1104	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CAAGCAAGCAGCTTAGGACAA	0.403000													9	20					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50367257	50367257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50367257G>A	ENST00000331340.3	+	3	219	c.64G>A	c.(64-66)Gat>Aat	p.D22N	IKZF1_ENST00000413698.1_Missense_Mutation_p.D22N|IKZF1_ENST00000359197.5_Missense_Mutation_p.D22N|IKZF1_ENST00000343574.5_Missense_Mutation_p.D22N|IKZF1_ENST00000440768.2_Missense_Mutation_p.D22N|IKZF1_ENST00000346667.4_Missense_Mutation_p.D22N|IKZF1_ENST00000492782.1_3'UTR|IKZF1_ENST00000438033.1_Missense_Mutation_p.D22N|IKZF1_ENST00000357364.4_Missense_Mutation_p.D22N|IKZF1_ENST00000349824.4_Missense_Mutation_p.D22N|IKZF1_ENST00000439701.1_Missense_Mutation_p.D22N	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	22					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(33)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CCCTGTAAGCGATACTCCAGA	0.587000			"""D,T"""	BCL6	"""ALL, DLBCL"""								7	18					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803315	54803315	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54803315G>A	ENST00000391745.1	-	8	729	c.413C>T	c.(412-414)gCc>gTc	p.A138V	LILRA3_ENST00000391744.3_Missense_Mutation_p.A121V|LILRA3_ENST00000251390.3_Missense_Mutation_p.A121V					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTTGCTGTAGGCTCCTAGGAG	0.602000													24	158					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46718188	46718188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46718188G>A	ENST00000318962.4	-	18	2055	c.1972C>T	c.(1972-1974)Ctg>Ttg	p.L658L	ALS2CL_ENST00000415953.1_Silent_p.L658L|ALS2CL_ENST00000383742.3_Silent_p.L5L	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	658					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AGCTCCTCCAGGATGTCTTCC	0.652000													26	51					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138697051	138697051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:138697051G>A	ENST00000520602.1	-	13	1817	c.1532C>T	c.(1531-1533)tCa>tTa	p.S511L	MCF2_ENST00000338585.6_Missense_Mutation_p.S451L|MCF2_ENST00000483690.1_5'UTR|MCF2_ENST00000519895.1_Missense_Mutation_p.S511L|MCF2_ENST00000370576.4_Missense_Mutation_p.S451L|MCF2_ENST00000536274.1_Missense_Mutation_p.S412L|MCF2_ENST00000414978.1_Missense_Mutation_p.S511L|MCF2_ENST00000370578.4_Missense_Mutation_p.S596L|MCF2_ENST00000370573.4_Missense_Mutation_p.S451L			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	451	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TTGTTTAGATGAAAAAAATGG	0.368000													54	58					0	0	1	0	0
NUAK1	9891	broad.mit.edu	37	12	106461006	106461006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:106461006C>T	ENST00000261402.2	-	7	2939	c.1560G>A	c.(1558-1560)cgG>cgA	p.R520R		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	520							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TGCCCTTCCTCCGGCAGGAGA	0.612000													19	59					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47401263	47401263	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47401263G>C	ENST00000310638.4	-	5	598	c.567C>G	c.(565-567)gtC>gtG	p.V189V	CYP4A11_ENST00000371904.4_Silent_p.V189V|CYP4A11_ENST00000457840.2_Silent_p.V85V|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371905.1_Silent_p.V189V	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	189					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	TCATCAAGGAGACGTGCTGAA	0.567000													14	67					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5182205	5182205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:5182205C>T	ENST00000274181.7	+	4	688	c.550C>T	c.(550-552)Cct>Tct	p.P184S	ADAMTS16_ENST00000511368.1_Missense_Mutation_p.P184S	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	184					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AAGGCCACTTCCTTCACACCT	0.488000													43	97					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23896011	23896011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23896011G>A	ENST00000355349.3	-	18	2181	c.2019C>T	c.(2017-2019)atC>atT	p.I673I		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	673	Actin-binding.|Myosin head-like.			CII -> LYH (in Ref. 2; CAA37068).	adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATTAGGGATGATACAACGTA	0.493000													19	52					0	0	1	0	0
CPVL	54504	broad.mit.edu	37	7	29160613	29160613	+	Missense_Mutation	SNP	C	C	T	rs148332481	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:29160613C>T	ENST00000409850.1	-	6	711	c.65G>A	c.(64-66)gGg>gAg	p.G22E	CPVL_ENST00000396276.3_Missense_Mutation_p.G22E|CPVL_ENST00000265394.5_Missense_Mutation_p.G22E|CPVL_ENST00000488891.2_5'UTR			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	22					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						GCGAAACAGCCCATCACAGGG	0.488000													34	67					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61941141	61941141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61941141C>T	ENST00000280772.1	-	18	2321	c.2130G>A	c.(2128-2130)gtG>gtA	p.V710V	ANK3_ENST00000503366.1_Silent_p.V693V|ANK3_ENST00000373827.2_Silent_p.V704V	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	710					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGCCACATTCACTCGATCTT	0.517000													45	103					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62579893	62579893	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62579893C>T	ENST00000371158.2	+	35	4744	c.4630C>T	c.(4630-4632)Ctg>Ttg	p.L1544L	INADL_ENST00000545929.1_Silent_p.L189L|INADL_ENST00000543708.1_Silent_p.L358L|INADL_ENST00000316485.6_Silent_p.L1574L	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1544	PDZ 9.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TGGCCGGGGCCTGGGCCTGAG	0.537000													14	46					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386606	56386606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56386606C>T	ENST00000355701.3	-	22	4897	c.4027G>A	c.(4027-4029)Gag>Aag	p.E1343K	BZRAP1_ENST00000268893.6_Missense_Mutation_p.E1283K|BZRAP1_ENST00000343736.4_Missense_Mutation_p.E1343K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1343	Poly-Glu.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tcctcctcctcgtcctcctct	0.607000													18	39					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140724405	140724405	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140724405C>T	ENST00000253812.6	+	1	805	c.805C>T	c.(805-807)Cct>Tct	p.P269S	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCACTGACCCTGACGAGGG	0.473000													9	44					0	0	1	0	0
ST7L	54879	broad.mit.edu	37	1	113084621	113084621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113084621G>A	ENST00000358039.4	-	14	1885	c.1581C>T	c.(1579-1581)gcC>gcT	p.A527A	ST7L_ENST00000538187.1_Silent_p.A471A|ST7L_ENST00000490067.1_Silent_p.A510A|ST7L_ENST00000369669.1_Silent_p.A344A|ST7L_ENST00000360743.4_Silent_p.A496A|ST7L_ENST00000343210.7_Silent_p.A527A|ST7L_ENST00000544629.1_Silent_p.A462A|ST7L_ENST00000369666.1_Silent_p.A510A|ST7L_ENST00000369668.2_Silent_p.A527A|ST7L_ENST00000463235.1_5'UTR	NM_017744.4|NM_138727.3	NP_060214.2|NP_620055.1	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7 like	527					negative regulation of cell growth	integral to membrane	binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(1)|prostate(2)|stomach(1)|urinary_tract(3)	15	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGTGAGAATGGCTATCATTG	0.378000													22	69					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22729303	22729303	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:22729303C>T	ENST00000503442.1	+	0	149				GBA3_ENST00000508166.1_RNA|GBA3_ENST00000511446.1_RNA	NM_001128432.2	NP_001121904.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TTCACATTTTCAAATGAAGAT	0.423000													75	199					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170139474	170139474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170139474C>T	ENST00000263816.3	-	10	1365	c.1080G>A	c.(1078-1080)caG>caA	p.Q360Q	LRP2_ENST00000443831.1_Silent_p.Q360Q	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	360	EGF-like 2.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTTCACACTTCTGGTCACAAA	0.433000													64	152					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5042699	5042699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:5042699C>T	ENST00000574788.1	+	22	3458	c.1228C>T	c.(1228-1230)Cgt>Tgt	p.R410C	USP6_ENST00000332776.4_Missense_Mutation_p.R410C|USP6_ENST00000304328.5_Missense_Mutation_p.R93C|USP6_ENST00000250066.6_Missense_Mutation_p.R410C			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	410					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						ATGGGCATCTCGTTTTTCCAC	0.657000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								17	28					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93624558	93624558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:93624558C>T	ENST00000375754.4	+	4	797	c.649C>T	c.(649-651)Cgc>Tgc	p.R217C	SYK_ENST00000375751.4_Missense_Mutation_p.R217C|SYK_ENST00000375747.1_Missense_Mutation_p.R217C|SYK_ENST00000375746.1_Missense_Mutation_p.R217C	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	217	SH2 2.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						GCTGCACTATCGCATCGACAA	0.577000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								6	28					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878113	24878113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24878113C>T	ENST00000382554.3	+	4	1431	c.1113C>T	c.(1111-1113)atC>atT	p.I371I		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	371					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TCTGGAGGATCAATGAGCTGC	0.607000													12	12					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101778392	101778392	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101778392G>A	ENST00000375001.3	+	11	2061	c.1638G>A	c.(1636-1638)tgG>tgA	p.W546*		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	546	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CTGAAAGATGGATCACTCCAG	0.597000													4	29					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59282609	59282609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59282609C>T	ENST00000329328.3	+	1	224	c.224C>T	c.(223-225)tCc>tTc	p.S75F		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						TGCTTTTCCTCCATCACAGCT	0.458000													17	187					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49662672	49662672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49662672C>T	ENST00000296452.4	+	2	603	c.489C>T	c.(487-489)ccC>ccT	p.P163P		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	163					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGATCGCCCCCCTTCCCAGCA	0.612000													32	88					0	0	1	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516385	138516385	+	Missense_Mutation	SNP	C	C	T	rs138281407	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138516385C>T	ENST00000371763.1	-	5	642	c.389G>A	c.(388-390)cGa>cAa	p.R130Q		NM_182974.2	NP_892019.2	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	130					carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	15		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		TTTGAACGTTCGAAGAGGACT	0.537000													5	47					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079286	57079286	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57079286G>A	ENST00000316981.3	-	5	1498	c.1019C>T	c.(1018-1020)tCa>tTa	p.S340L	PLAG1_ENST00000429357.2_Missense_Mutation_p.S340L|PLAG1_ENST00000423799.2_Missense_Mutation_p.S258L	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	340	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			AATTGCATATGAGGTAGAACT	0.418000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								21	194					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167517659	167517659	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167517659C>T	ENST00000519204.1	+	7	1351	c.1233C>T	c.(1231-1233)acC>acT	p.T411T	TENM2_ENST00000403607.2_Silent_p.T365T|TENM2_ENST00000545108.1_Silent_p.T532T|TENM2_ENST00000518659.1_Silent_p.T532T|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000520394.1_Silent_p.T300T					teneurin transmembrane protein 2									p.T365T(1)									GCATACAGACCTTGGTTCAGA	0.507000													36	110					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56183149	56183149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:56183149G>A	ENST00000288221.6	-	5	1416	c.1161C>T	c.(1159-1161)atC>atT	p.I387I		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	387						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CCAATGAAGCGATTTTTGTGT	0.333000													5	28					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40074023	40074023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40074023G>A	ENST00000336649.4	+	34	4983	c.4983G>A	c.(4981-4983)atG>atA	p.M1661I	CACNA1I_ENST00000404898.1_Missense_Mutation_p.M1620I|CACNA1I_ENST00000402142.3_Missense_Mutation_p.M1655I|CACNA1I_ENST00000401624.1_Missense_Mutation_p.M1655I|CACNA1I_ENST00000400164.3_Missense_Mutation_p.M1620I|CACNA1I_ENST00000407673.1_Missense_Mutation_p.M1620I			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1655					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GCGAGGGCATGAGCCGGCATG	0.637000													3	8					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26743814	26743814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26743814G>A	ENST00000529632.2	+	11	2538	c.2342G>A	c.(2341-2343)gGg>gAg	p.G781E	SEZ6L_ENST00000411842.2_5'UTR|SEZ6L_ENST00000343706.4_Missense_Mutation_p.G781E|SEZ6L_ENST00000360929.3_Missense_Mutation_p.G781E|SEZ6L_ENST00000404234.3_Missense_Mutation_p.G781E|SEZ6L_ENST00000248933.6_Missense_Mutation_p.G781E|SEZ6L_ENST00000402979.1_Missense_Mutation_p.G554E|SEZ6L_ENST00000403121.1_Missense_Mutation_p.G554E	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	781	Sushi 3.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GACATCGTGGGGAGTGACACC	0.557000													35	91					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723446	48723446	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48723446G>A	ENST00000335017.1	+	1	684	c.372G>A	c.(370-372)aaG>aaA	p.K124K		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	124					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						GGGTCTGGAAGGTTCCCAAGC	0.746000													11	20					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179571363	179571363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179571363G>A	ENST00000589042.1	-	102	29462	c.29238C>T	c.(29236-29238)ttC>ttT	p.F9746F	TTN_ENST00000342992.6_Silent_p.F8502F|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.F9429F|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9429	Ig-like 78.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTGGATGAAAACACGAC	0.453000													36	185					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42719404	42719404	+	Missense_Mutation	SNP	C	C	T	rs144782781		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:42719404C>T	ENST00000230882.4	+	10	1985	c.1795C>T	c.(1795-1797)Cat>Tat	p.H599Y	GHR_ENST00000357703.3_Missense_Mutation_p.H577Y|GHR_ENST00000537449.1_Missense_Mutation_p.H412Y	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	599					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TACCTCCATTCATATAGTACA	0.512000													14	44					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30705332	30705332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30705332G>A	ENST00000256246.2	-	1	1276	c.1202C>T	c.(1201-1203)tCa>tTa	p.S401L		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	401										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GTTATAAGATGAAATAACTGT	0.333000													19	99					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020463	56020463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56020463G>A	ENST00000303059.3	+	1	788	c.788G>A	c.(787-789)gGa>gAa	p.G263E		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TCTGCTAAGGGAAGGCAAAAG	0.408000													65	168					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76900491	76900491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76900491C>T	ENST00000409709.3	+	28	3878	c.3606C>T	c.(3604-3606)ttC>ttT	p.F1202F	MYO7A_ENST00000409619.2_Silent_p.F1191F|MYO7A_ENST00000458637.2_Silent_p.F1202F	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1202	MyTH4 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TGGGCTGTTTCGCCCCCTCCG	0.607000													32	79					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10231363	10231363	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10231363C>T	ENST00000377157.3	+	24	3827	c.2766C>T	c.(2764-2766)ttC>ttT	p.F922F	UBE4B_ENST00000253251.8_Silent_p.F1038F|UBE4B_ENST00000343090.6_Silent_p.F1167F	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	1167					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GTGCTCGGTTCGCGAAAGCCA	0.478000													52	115					0	0	1	0	0
ZNF786	136051	broad.mit.edu	37	7	148768966	148768966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148768966G>A	ENST00000316286.9	-	3	912	c.640C>T	c.(640-642)Cca>Tca	p.P214S	ZNF786_ENST00000491431.1_Missense_Mutation_p.P300S|ZNF786_ENST00000451334.3_Missense_Mutation_p.P263S			Q8N393	ZN786_HUMAN	zinc finger protein 786	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TTGCCGCATGGGGTGCACTGG	0.706000													8	23					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88583472	88583472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88583472G>A	ENST00000339673.6	+	6	641	c.542G>A	c.(541-543)gGt>gAt	p.G181D	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.G165D|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	181					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CCTGAGGGAGGTGACTCCACT	0.587000													13	34					0	0	1	0	0
PAK3	5063	broad.mit.edu	37	X	110439146	110439146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:110439146G>A	ENST00000519681.1	+	16	1692	c.1250G>A	c.(1249-1251)gGg>gAg	p.G417E	PAK3_ENST00000262836.4_Missense_Mutation_p.G411E|PAK3_ENST00000518291.1_Missense_Mutation_p.G432E|PAK3_ENST00000417227.1_Missense_Mutation_p.G417E|PAK3_ENST00000372007.4_Missense_Mutation_p.G396E|PAK3_ENST00000446737.1_Missense_Mutation_p.G396E|PAK3_ENST00000360648.4_Missense_Mutation_p.G432E|PAK3_ENST00000372010.1_Missense_Mutation_p.G411E|PAK3_ENST00000425146.1_Missense_Mutation_p.G396E			O75914	PAK3_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 3	411	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						ATTCTTCTCGGGATGGATGGC	0.358000										TSP Lung(19;0.15)			70	49					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53520004	53520004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:53520004C>T	ENST00000370905.3	-	2	207	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K	KLHL31_ENST00000407079.1_Missense_Mutation_p.E23K	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	23					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					GGGCTATCTTCTACGATTATA	0.418000													21	47					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6477676	6477676	+	Missense_Mutation	SNP	G	G	A	rs138597075		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6477676G>A	ENST00000525074.1	-	6	1674	c.1280C>T	c.(1279-1281)tCc>tTc	p.S427F	TRIM3_ENST00000359518.3_Missense_Mutation_p.S427F|TRIM3_ENST00000529058.1_Intron|TRIM3_ENST00000536344.1_Missense_Mutation_p.S308F|TRIM3_ENST00000345851.3_Missense_Mutation_p.S427F|TRIM3_ENST00000537602.1_Missense_Mutation_p.S349F	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	427					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCGTCCGGGGAAGGTGGCAG	0.697000													13	21					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1513989	1513989	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:1513989G>A	ENST00000389470.4	-	42	6255	c.6256C>T	c.(6256-6258)Ccc>Tcc	p.P2086S	INTS1_ENST00000404767.3_Missense_Mutation_p.P1882S			Q8N201	INT1_HUMAN	integrator complex subunit 1	1882					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCGATCATGGGCAGGTGCCTG	0.726000													6	28					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153661707	153661707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153661707G>A	ENST00000368680.3	+	17	3080	c.2608G>A	c.(2608-2610)Gaa>Aaa	p.E870K		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	870					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GGTGCAGGCCGAAGCCTTTGA	0.602000													33	106					0	0	1	0	0
GNA11	2767	broad.mit.edu	37	19	3119345	3119345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3119345C>T	ENST00000078429.4	+	6	1119	c.877C>T	c.(877-879)Ccc>Tcc	p.P293S	GNA11_ENST00000586180.1_3'UTR	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	293					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		GGACTACTTCCCCGAGTTCGA	0.632000			Mis		uveal melanoma								32	72					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118351390	118351390	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118351390G>C	ENST00000528052.1	+	3	228	c.157G>C	c.(157-159)Ggc>Cgc	p.G53R	PNLIPRP1_ENST00000534537.1_Missense_Mutation_p.G53R|PNLIPRP1_ENST00000442761.1_Missense_Mutation_p.G53R|PNLIPRP1_ENST00000358834.4_Missense_Mutation_p.G53R|PNLIPRP1_ENST00000480870.2_3'UTR			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	53					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		TGAGAAGATCGGCACCCGCTT	0.532000													19	156					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57333376	57333376	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57333376G>A	ENST00000361249.3	+	2	267		c.e2+1			NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGACAAAAAGGTGAGACACTT	0.493000													17	59					0	0	1	0	0
AAAS	8086	broad.mit.edu	37	12	53708591	53708591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53708591G>A	ENST00000209873.4	-	6	654	c.489C>T	c.(487-489)acC>acT	p.T163T	AAAS_ENST00000549983.1_5'UTR|AAAS_ENST00000550286.1_Silent_p.T39T|AAAS_ENST00000394384.3_Intron	NM_015665.5	NP_056480.1	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency, alacrimia	163					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	20						CAAACTTGTTGGTGTGGGGGT	0.542000													7	19					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94288954	94288954	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94288954A>G	ENST00000515393.1	-	3	949	c.950T>C	c.(949-951)gTt>gCt	p.V317A	MCTP1_ENST00000312216.8_Missense_Mutation_p.V96A|MCTP1_ENST00000429576.2_Missense_Mutation_p.V96A|MCTP1_ENST00000505208.1_Missense_Mutation_p.V96A	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	317	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		AAGATGATCAACCAGAATACA	0.353000													6	25					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78571017	78571017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:78571017C>T	ENST00000397909.2	+	27	5394	c.5221C>T	c.(5221-5223)Ccg>Tcg	p.P1741S	NAV3_ENST00000266692.7_Missense_Mutation_p.P1564S|NAV3_ENST00000536525.2_Missense_Mutation_p.P1741S|NAV3_ENST00000228327.6_Missense_Mutation_p.P1741S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1741						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTCATCCCTTCCGGCATCCCC	0.473000										HNSCC(70;0.22)			48	129					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20258009	20258009	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20258009G>A	ENST00000245957.5	+	22	2779	c.2703G>A	c.(2701-2703)gcG>gcA	p.A901A	C20orf26_ENST00000377309.2_Silent_p.A257A	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	901										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ACCGGGATGCGATCCTGGCCC	0.632000													35	106					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307866	46307866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46307866C>T	ENST00000221538.3	-	3	1439	c.1297G>A	c.(1297-1299)Gag>Aag	p.E433K	RSPH6A_ENST00000597055.1_Missense_Mutation_p.E433K|RSPH6A_ENST00000600188.1_Missense_Mutation_p.E169K	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	433						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						AGGCCCGGCTCGTTGCACACA	0.617000													20	55					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135428894	135428894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135428894C>T	ENST00000394143.1	+	6	3320	c.3029C>T	c.(3028-3030)cCt>cTt	p.P1010L	GPR112_ENST00000370652.1_Missense_Mutation_p.P1010L|GPR112_ENST00000287534.4_Missense_Mutation_p.P947L|GPR112_ENST00000394141.1_Missense_Mutation_p.P805L|GPR112_ENST00000412101.1_Missense_Mutation_p.P805L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1010					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ACCCCTGTGCCTGTTACTCAT	0.507000													76	52					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94134256	94134256	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94134256T>G	ENST00000243673.2	-	1	329	c.158A>C	c.(157-159)cAg>cCg	p.Q53P	GPR83_ENST00000539203.2_Missense_Mutation_p.Q53P	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	53						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CACAAAGTTCTGCCAGTCGGA	0.612000													13	61					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122634644	122634644	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122634644C>T	ENST00000195173.4	-	13	2085	c.1782G>A	c.(1780-1782)tgG>tgA	p.W594*	SEMA5B_ENST00000357599.3_Nonsense_Mutation_p.W594*|SEMA5B_ENST00000451055.2_Nonsense_Mutation_p.W648*			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	594					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		TGTTCTGGGTCCAGAGGCTCA	0.607000													15	64					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57113848	57113848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57113848G>A	ENST00000454682.1	-	3	1747	c.1466C>T	c.(1465-1467)gCt>gTt	p.A489V	NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Missense_Mutation_p.A489V|NACA_ENST00000548563.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTCTTTGGGAGCCACAGGTGC	0.493000			T	BCL6	NHL								11	70					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16760838	16760838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:16760838C>T	ENST00000502640.1	-	2	326	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	LDB2_ENST00000304523.5_Missense_Mutation_p.E60K|LDB2_ENST00000441778.2_Missense_Mutation_p.E60K|LDB2_ENST00000515064.1_Missense_Mutation_p.E60K			O43679	LDB2_HUMAN	LIM domain binding 2	60							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						GCGTCATCTTCAAAAAATTCA	0.378000													28	74					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143961164	143961164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143961164C>T	ENST00000292427.4	-	1	98	c.66G>A	c.(64-66)caG>caA	p.Q22Q	CYP11B1_ENST00000377675.3_Silent_p.Q22Q|CYP11B1_ENST00000517471.1_Silent_p.Q22Q	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	22					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	TGCCCAGTGCCTGTGCCCTTT	0.642000									Familial Hyperaldosteronism type I				48	98					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617544	111617544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111617544C>T	ENST00000374667.3	-	1	1695	c.667G>A	c.(667-669)Gac>Aac	p.D223N		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	223						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CCAGCGTAGTCGGCGCGGCTG	0.657000													14	59					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177249620	177249620	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177249620C>T	ENST00000361539.4	+	8	1620	c.1308C>T	c.(1306-1308)ttC>ttT	p.F436F	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		436						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CTGGCACTTTCCTGGAACAGA	0.577000													27	74					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38557331	38557331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38557331G>A	ENST00000423485.1	-	21	2593	c.2435C>T	c.(2434-2436)tCt>tTt	p.S812F		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	812					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TCGAGCCAAAGAGCTAAAGAA	0.308000													22	18					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71482455	71482455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71482455C>T	ENST00000296755.7	+	4	682	c.384C>T	c.(382-384)atC>atT	p.I128I		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	128						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GCTTAATGATCACTGATGCTG	0.557000													37	116					0	0	1	0	0
NEDD9	4739	broad.mit.edu	37	6	11191312	11191312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:11191312G>A	ENST00000379446.5	-	5	956	c.790C>T	c.(790-792)Cct>Tct	p.P264S	NEDD9_ENST00000504387.1_Missense_Mutation_p.P264S|RP3-510L9.1_ENST00000500636.2_RNA	NM_001271033.1|NM_006403.3	NP_001257962.1|NP_006394.1	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally down-regulated 9	264					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			CAGGTTGGAGGAATGTCATAA	0.557000													19	85					0	0	1	0	0
CA6	765	broad.mit.edu	37	1	9009324	9009324	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9009324G>A	ENST00000377443.2	+	2	86	c.82G>A	c.(82-84)Ggg>Agg	p.G28R	CA6_ENST00000377442.2_Intron|CA6_ENST00000476083.1_Intron|CA6_ENST00000319474.2_Missense_Mutation_p.G28R|CA6_ENST00000377436.3_Missense_Mutation_p.G28R	NM_001215.3	NP_001206.2	P23280	CAH6_HUMAN	carbonic anhydrase VI	28					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCTTAGAAGGGGCACTGGA	0.642000													7	32					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97080982	97080982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:97080982G>A	ENST00000253262.4	-	7	2056	c.2036C>T	c.(2035-2037)cCa>cTa	p.P679L	NUTM2F_ENST00000335456.7_Intron|NUTM2F_ENST00000341207.4_Missense_Mutation_p.P664L	NM_017561.1	NP_060031.1			NUT family member 2F																		CTGAGCAGATGGAGACTGAAG	0.612000													5	11					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11666769	11666769	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11666769C>T	ENST00000262442.3	+	36	7076	c.7008C>T	c.(7006-7008)atC>atT	p.I2336I	DNAH9_ENST00000454412.2_Silent_p.I2336I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2336					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.I2336I(1)		NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTAAGAAGATCATTCCCATCC	0.498000													41	78					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34026758	34026758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34026758G>A	ENST00000374181.3	-	4	1189	c.1020C>T	c.(1018-1020)tcC>tcT	p.S340S	GRM4_ENST00000535756.1_Silent_p.S207S|GRM4_ENST00000374177.3_Silent_p.S271S|GRM4_ENST00000538487.1_Silent_p.S340S|GRM4_ENST00000545715.1_Silent_p.S32S|GRM4_ENST00000455714.2_Silent_p.S200S|GRM4_ENST00000544773.1_Silent_p.S171S	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	340					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	TACCTCGTACGGACATCCTCT	0.632000													7	24					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987555	61987555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61987555C>T	ENST00000450719.3	-	3	393	c.156G>A	c.(154-156)aaG>aaA	p.K52K	CSHL1_ENST00000346606.6_Silent_p.K52K|CSHL1_ENST00000561003.1_Silent_p.K63K|CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000438387.2_Silent_p.K63K|CSHL1_ENST00000259003.10_Silent_p.K84K|CSHL1_ENST00000309894.5_Silent_p.K146K			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	146						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						CCTCTAGGTCCTTTAGGAGGT	0.592000													7	78					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118866123	118866123	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:118866123T>C	ENST00000295622.1	+	1	1127	c.1087T>C	c.(1087-1089)Tat>Cat	p.Y363H		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	363										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		GCTGTCTTACTATGAAACACG	0.448000													16	46					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151067847	151067847	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151067847G>A	ENST00000474524.1	+	15	2184	c.2145_splice	c.e15-1	p.D716_splice	MED12L_ENST00000273432.4_Splice_Site_p.D576_splice|P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000491549.1_3'UTR	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	716					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGTTTTTCAGGATGAATCTTC	0.458000													110	328					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111078149	111078149	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:111078149G>A	ENST00000262839.2	-	7	2814	c.1896_splice	c.e7+1	p.A632_splice		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	632					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGCTACTCACGGCAATAAGCT	0.443000													77	43					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153085278	153085278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153085278C>T	ENST00000285900.5	+	11	1817	c.1474C>T	c.(1474-1476)Ccc>Tcc	p.P492S	GRIA1_ENST00000518783.1_Missense_Mutation_p.P502S|GRIA1_ENST00000521843.2_Missense_Mutation_p.P423S|GRIA1_ENST00000340592.5_Missense_Mutation_p.P492S|GRIA1_ENST00000448073.4_Missense_Mutation_p.P502S|GRIA1_ENST00000518142.1_Missense_Mutation_p.P412S	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	492	Glutamate binding (By similarity).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGCTGTGGCTCCCTTAACTAT	0.358000													11	35					0	0	1	0	0
LAX1	54900	broad.mit.edu	37	1	203743176	203743176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203743176G>A	ENST00000442561.2	+	5	954	c.564G>A	c.(562-564)gaG>gaA	p.E188E	LAX1_ENST00000367217.5_Silent_p.E172E|LAX1_ENST00000367215.1_3'UTR	NM_017773.3	NP_060243.2	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1	188					B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)|endometrium(3)|large_intestine(2)|lung(13)|prostate(1)|stomach(1)|urinary_tract(2)	24	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TTTCTTCAGAGGATTCGCATG	0.493000													36	79					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372580	126372580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126372580G>A	ENST00000394329.3	+	9	10422	c.10409G>A	c.(10408-10410)cGa>cAa	p.R3470Q	FAT4_ENST00000335110.5_Missense_Mutation_p.R1768Q	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3470	Cadherin 33.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAATTAGATCGAGAAACCCTT	0.443000													52	118					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108622612	108622612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108622612G>A	ENST00000264047.2	+	7	1125	c.849G>A	c.(847-849)gtG>gtA	p.V283V	SLC5A7_ENST00000540517.1_Silent_p.V178V|SLC5A7_ENST00000409059.1_Silent_p.V283V	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	283					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	GGTGCCTGGTGATGGCCATCC	0.527000													33	76					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18829902	18829902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18829902G>A	ENST00000380548.4	+	23	4515	c.4176G>A	c.(4174-4176)ccG>ccA	p.P1392P	ADAMTSL1_ENST00000380545.5_Silent_p.P93P	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1392						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCACTGGACCGAACCTTCCTT	0.567000													13	27					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6244522	6244522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6244522G>A	ENST00000400104.3	-	6	485	c.285C>T	c.(283-285)ccC>ccT	p.P95P	L3MBTL4_ENST00000400105.2_Silent_p.P95P|L3MBTL4_ENST00000317931.7_Silent_p.P95P|L3MBTL4_ENST00000284898.6_Silent_p.P95P			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	95					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				ATGGATGTCGGGGATCAATGC	0.418000													68	149					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37486340	37486340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37486340C>T	ENST00000374660.1	+	35	2936	c.2837C>T	c.(2836-2838)gCc>gTc	p.A946V	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.A827V|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.A827V			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	997						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.A827V(1)		NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATTTAGCCTGCCATTGAAATG	0.308000													36	103					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380062	56380062	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56380062C>A	ENST00000526538.1	-	1	916	c.917G>T	c.(916-918)aGg>aTg	p.R306M		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						GGATTTTCCCCTAATCATTTG	0.373000													29	195					2.14196e-07	2.148e-07	1	1	0
CEP44	80817	broad.mit.edu	37	4	175224908	175224908	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175224908C>T	ENST00000503780.1	+	5	706	c.292C>T	c.(292-294)Caa>Taa	p.Q98*	CEP44_ENST00000457424.2_Nonsense_Mutation_p.Q98*|CEP44_ENST00000296519.4_Nonsense_Mutation_p.Q98*|CEP44_ENST00000426172.1_Nonsense_Mutation_p.Q98*	NM_001040157.2	NP_001035247.1	Q9C0F1	CEP44_HUMAN	centrosomal protein 44kDa	98						centrosome|midbody|spindle pole				endometrium(2)|large_intestine(4)|lung(5)|stomach(1)	12						GCAGTTTATCCAATGTGGGTT	0.318000													15	42					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158607975	158607975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158607975G>A	ENST00000368148.3	-	36	5217	c.5037C>T	c.(5035-5037)ttC>ttT	p.F1679F	SPTA1_ENST00000368147.3_Silent_p.F1679F	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1679					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GATCAACGTTGAAAGTCCCGC	0.423000													22	35					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196871677	196871677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196871677C>T	ENST00000367416.2	+	2	322	c.185C>T	c.(184-186)cCt>cTt	p.P62L	CFHR4_ENST00000367418.1_Intron|CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000251424.4_Missense_Mutation_p.P63L	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						TTTGTGACTCCTTCAGGAAGT	0.398000													56	158					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22313149	22313149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22313149C>T	ENST00000337107.6	+	7	787	c.768C>T	c.(766-768)gtC>gtT	p.V256V	CELA3B_ENST00000473526.1_3'UTR	NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	256	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						TCACTCGAGTCTCCGCCTTCA	0.607000													12	51					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9066649	9066649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:9066649C>T	ENST00000382496.5	-	17	2848	c.2183G>A	c.(2182-2184)cGa>cAa	p.R728Q		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	728	TSP type-1 4.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GTATCGGAATCGTTGCTCATA	0.547000													53	115					0	0	1	0	0
ZFP28	140612	broad.mit.edu	37	19	57065579	57065579	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57065579C>T	ENST00000301318.3	+	8	1496	c.1425C>T	c.(1423-1425)ccC>ccT	p.P475P	AC007228.11_ENST00000596587.1_RNA	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GCAAGAAGCCCTATGAGTGCA	0.463000													22	64					0	0	1	0	0
OR51A2	401667	broad.mit.edu	37	11	4976592	4976592	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4976592G>A	ENST00000380371.1	-	1	351	c.352C>T	c.(352-354)Ctg>Ttg	p.L118L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004748.1	NP_001004748.1	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GACATGATCAGGAGGACTGAG	0.448000													23	25					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55080480	55080480	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55080480G>A	ENST00000302250.2	-	4	628	c.468C>T	c.(466-468)ctC>ctT	p.L156L	FAM151A_ENST00000371304.2_Silent_p.L156L|ACOT11_ENST00000371316.3_Intron	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	156						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						GCTGCCGCAGGAGGTCCAGGG	0.552000													14	52					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53398087	53398087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:53398087C>T	ENST00000226067.5	+	4	1208	c.735C>T	c.(733-735)gcC>gcT	p.A245A	HLF_ENST00000575307.1_3'UTR|HLF_ENST00000430986.2_Silent_p.A160A|HLF_ENST00000573945.1_Silent_p.A160A|HLF_ENST00000575345.1_Silent_p.A160A	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	245					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						CCCGCGACGCCCGGAGGCTGA	0.567000			T	TCF3	ALL								11	42					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922993	24922993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922993C>T	ENST00000329468.2	+	1	2453	c.1979C>T	c.(1978-1980)tCt>tTt	p.S660F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CAGAAAGCTTCTCTCCCCAGT	0.498000													22	160					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436263	248436263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248436263G>A	ENST00000318021.2	-	1	875	c.854C>T	c.(853-855)cCc>cTc	p.P285L		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P285L(1)		NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTAGATGAGGGGGTTTAGTAA	0.478000													47	232					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139873743	139873743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139873743G>A	ENST00000224167.2	+	3	398	c.323G>A	c.(322-324)cGg>cAg	p.R108Q	PTGDS_ENST00000371625.3_Missense_Mutation_p.R108Q|PTGDS_ENST00000460340.1_3'UTR			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	108					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TACAGCTACCGGAGTCCCCGT	0.687000													23	62					0	0	1	0	0
ANKRD13A	88455	broad.mit.edu	37	12	110463606	110463606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110463606G>A	ENST00000261739.4	+	8	1027	c.861G>A	c.(859-861)gaG>gaA	p.E287E		NM_033121.1	NP_149112.1	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13A	287										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						ATCTGACCGAGGAGGAAAAAA	0.413000													43	95					0	0	1	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808058	18808058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18808058G>A	ENST00000400664.1	+	1	635	c.583G>A	c.(583-585)Gag>Aag	p.E195K		NM_152375.2	NP_689588.2	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	195						integral to membrane		p.E195K(1)		endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TAAACCCCGTGAGCATCCAGG	0.612000													17	51					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10756197	10756197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10756197C>T	ENST00000416569.2	-	3	1217	c.1191G>A	c.(1189-1191)atG>atA	p.M397I	XKR6_ENST00000304437.2_Missense_Mutation_p.M118I	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	397						integral to membrane		p.M397I(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		TCCAGAAGGCCATGGCGCACC	0.512000													7	60					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7569539	7569539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7569539C>T	ENST00000379802.3	+	12	1881	c.1540C>T	c.(1540-1542)Cct>Tct	p.P514S	DSP_ENST00000418664.2_Missense_Mutation_p.P514S	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	514	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GATCATCCCTCCTCCGAACCC	0.577000													25	96					0	0	1	0	0
CA13	377677	broad.mit.edu	37	8	86163062	86163062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:86163062C>T	ENST00000321764.3	+	2	433	c.131C>T	c.(130-132)tCc>tTc	p.S44F	CA13_ENST00000517298.1_3'UTR	NM_198584.2	NP_940986.1	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	44					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding			large_intestine(1)|lung(6)	7						TATGACTCTTCCCTCCGACCA	0.398000													66	140					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778460	31778460	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31778460G>A	ENST00000375654.4	-	2	1479	c.1290C>T	c.(1288-1290)ttC>ttT	p.F430F	HSPA1L_ENST00000417199.3_Silent_p.F430F	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	430					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						AGTAGGTGGTGAAAATCTGTG	0.597000													81	158					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411138	23411138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23411138G>A	ENST00000379361.4	+	3	2363	c.1503G>A	c.(1501-1503)aaG>aaA	p.K501K		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	501					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						CCTATGTCAAGCCTTTTGTAG	0.428000													81	57					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219894230	219894230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219894230G>A	ENST00000341552.5	-	11	1628	c.1545C>T	c.(1543-1545)gcC>gcT	p.A515A	CCDC108_ENST00000409865.3_Silent_p.A504A|CCDC108_ENST00000441968.1_Silent_p.A515A|CCDC108_ENST00000410037.1_Silent_p.A450A|CCDC108_ENST00000453220.1_Silent_p.A515A	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	515						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGTCCCAAAGGCAGGCCTGA	0.602000											OREG0015211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	32					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54535277	54535277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54535277C>T	ENST00000566473.2	+	13	1503	c.1503C>T	c.(1501-1503)tcC>tcT	p.S501S	ANKFN1_ENST00000318698.2_Silent_p.S501S			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	501										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						TACCAATATCCTCATCCTCAT	0.502000													35	74					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94109943	94109943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94109943G>A	ENST00000553484.1	+	36	6281	c.6127G>A	c.(6127-6129)Gag>Aag	p.E2043K	UNC79_ENST00000555664.1_Missense_Mutation_p.E1982K|UNC79_ENST00000393151.2_Missense_Mutation_p.E2021K|UNC79_ENST00000256339.4_Missense_Mutation_p.E1844K			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2021						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ATACGATGAAGAGACACTTGG	0.483000													36	71					0	0	1	0	0
C9orf129	445577	broad.mit.edu	37	9	96097715	96097715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96097715G>A	ENST00000375419.1	-	3	669	c.306C>T	c.(304-306)ttC>ttT	p.F102F		NM_001098808.1	NP_001092278.1	Q5T035	CI129_HUMAN	chromosome 9 open reading frame 129	102										endometrium(2)|large_intestine(1)|lung(1)|ovary(2)	6						AAGAGCCAGGGAAGTAGGCGG	0.627000													12	36					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48620047	48620047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48620047G>A	ENST00000328333.8	-	44	4665	c.4558C>T	c.(4558-4560)Cct>Tct	p.P1520S	COL7A1_ENST00000454817.1_Missense_Mutation_p.P1520S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1520	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCACTTCAGGACCCTTGGCT	0.602000													15	54					0	0	1	0	0
PER2	8864	broad.mit.edu	37	2	239181733	239181733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239181733G>A	ENST00000254657.3	-	5	827	c.548C>T	c.(547-549)tCt>tTt	p.S183F	PER2_ENST00000254658.3_Missense_Mutation_p.S183F|PER2_ENST00000440245.1_Missense_Mutation_p.S183F|PER2_ENST00000355768.2_Missense_Mutation_p.S183F	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	183	PAS 1.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		AATGTGCTCAGAGGTAACGCT	0.552000													22	58					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285643	223285643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:223285643C>T	ENST00000540964.1	-	4	1192	c.731G>A	c.(730-732)gGa>gAa	p.G244E	TLR5_ENST00000342210.6_Missense_Mutation_p.G244E			O60602	TLR5_HUMAN	toll-like receptor 5	244					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		GCTAAAGTTTCCTGTGATGTC	0.468000													41	107					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	173024	173024	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:173024G>A	ENST00000283426.6	+	15	3045	c.2995G>A	c.(2995-2997)Gaa>Aaa	p.E999K		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	999	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GAATTTGAAGGAACAGGGGCA	0.498000													31	74					0	0	1	0	0
POU4F2	5458	broad.mit.edu	37	4	147561322	147561322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:147561322C>T	ENST00000281321.3	+	2	840	c.592C>T	c.(592-594)Ccc>Tcc	p.P198S		NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	198					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					GCACCTGAGTCCCGGGCTGGC	0.711000													4	10					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200967679	200967679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200967679G>A	ENST00000332129.2	-	14	2226	c.1910C>T	c.(1909-1911)gCc>gTc	p.A637V	KIF21B_ENST00000461742.2_Missense_Mutation_p.A637V|KIF21B_ENST00000360529.5_Missense_Mutation_p.A637V|KIF21B_ENST00000422435.2_Missense_Mutation_p.A637V	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	637					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						AGTCAGGTCGGCCAGGTCCGC	0.587000													27	61					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88658671	88658671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:88658671G>A	ENST00000340700.5	-	5	1201	c.750C>T	c.(748-750)atC>atT	p.I250I	KCNK10_ENST00000319231.5_Silent_p.I255I|KCNK10_ENST00000312350.5_Silent_p.I255I	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	250					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						TGACAGCAGGGATCGTCACAA	0.502000													33	112					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101183219	101183219	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101183219G>A	ENST00000313669.7	+	0	685				COL26A1_ENST00000397927.3_RNA|COL26A1_ENST00000528707.1_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		CCCGGACAACGACCTGCCAGC	0.632000													12	43					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35874645	35874645	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35874645G>A	ENST00000303115.3	+	6	929		c.e6+1		IL7R_ENST00000506850.1_Intron|IL7R_ENST00000343305.4_Intron	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor						immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GGAAAAAAAGGTGACCTTCTT	0.428000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						26	84					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16276673	16276673	+	Silent	SNP	G	G	A	rs57866002		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16276673G>A	ENST00000205557.7	-	16	2087	c.2058C>T	c.(2056-2058)ttC>ttT	p.F686F	ABCC6_ENST00000574094.1_Intron	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	686	ABC transporter 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CGATGCTCACGAACCCCTCCA	0.652000													18	49					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151105886	151105886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151105886G>A	ENST00000341697.3	-	19	3558	c.1867C>T	c.(1867-1869)Ctc>Ttc	p.L623F				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	623						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGACCAGGAGGCCAGAGACT	0.721000													4	15					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228491481	228491481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228491481G>A	ENST00000570156.2	+	52	13918	c.13844G>A	c.(13843-13845)cGg>cAg	p.R4615Q	OBSCN_ENST00000366707.4_Missense_Mutation_p.R1305Q|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000359599.6_3'UTR|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366709.4_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3658					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GTGGAGTGGCGGAAGGGGTCT	0.607000													29	61					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834783	125834783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125834783G>A	ENST00000299308.3	+	2	846	c.838G>A	c.(838-840)Gag>Aag	p.E280K		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	280						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAGCTTGGACGAGAATGTGGT	0.567000													63	157					0	0	1	0	0
RIPPLY2	134701	broad.mit.edu	37	6	84567100	84567100	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:84567100G>A	ENST00000369689.1	+	4	530	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	RIPPLY2_ENST00000369687.1_Missense_Mutation_p.E69K	NM_001009994.1	NP_001009994.1	Q5TAB7	RIPP2_HUMAN	ripply transcriptional repressor 2	127					somite rostral/caudal axis specification	nucleus				large_intestine(2)|lung(4)|urinary_tract(1)	7						TCTGACCTGTGAAAATTAATC	0.289000													30	63					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166893029	166893029	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166893029G>A	ENST00000423058.2	-	16	2975	c.2958C>T	c.(2956-2958)ctC>ctT	p.L986L	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Silent_p.L975L|SCN1A_ENST00000303395.4_Silent_p.L986L|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.L958L	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	986			L -> F (in SMEI; complete loss of function; dbSNP:rs121918625).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGGCCAGAAAGAGATTCAGGA	0.363000													13	37					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037935	75037935	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75037935C>T	ENST00000326665.5	-	14	3677	c.3459G>A	c.(3457-3459)gtG>gtA	p.V1153V	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1153	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						ATATGGGAACCACTGTCTCTT	0.468000													24	76					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14561721	14561721	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14561721G>A	ENST00000273083.3	-	0	991							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CTCAAGCAGCGAGCAGTGTTC	0.647000													6	34					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69416525	69416525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69416525G>A	ENST00000317746.2	-	5	1225	c.1183C>T	c.(1183-1185)Ccc>Tcc	p.P395S		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	395					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						GCAAACAAGGGAATGCCCACC	0.458000													75	119					0	0	1	0	0
IL17RC	84818	broad.mit.edu	37	3	9959119	9959119	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9959119C>T	ENST00000295981.3	+	1	338	c.120C>T	c.(118-120)ccC>ccT	p.P40P	IL17RC_ENST00000383812.4_Intron|IL17RC_ENST00000416074.2_Intron|IL17RC_ENST00000455057.1_Intron|IL17RC_ENST00000403601.3_Intron|IL17RC_ENST00000498214.1_Intron|IL17RC_ENST00000413608.1_Intron	NM_153461.3	NP_703191.1	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C	40						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GTCTGGAACCCTGGGGAGACG	0.607000													17	55					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075309	106075309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106075309G>A	ENST00000278071.2	-	3	953	c.501C>T	c.(499-501)ttC>ttT	p.F167F	ITPRIP_ENST00000358187.2_Silent_p.F167F|ITPRIP_ENST00000337478.1_Silent_p.F167F	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	167						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						AGTCATCCACGAAGCCTTCCA	0.622000													32	76					0	0	1	0	0
DCAF7	10238	broad.mit.edu	37	17	61660954	61660954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61660954C>T	ENST00000310827.4	+	6	836	c.619C>T	c.(619-621)Cgc>Tgc	p.R207C	DCAF7_ENST00000577702.1_3'UTR|DCAF7_ENST00000415273.2_Intron|DCAF7_ENST00000431926.1_Intron	NM_005828.3	NP_005819.3	P61962	DCAF7_HUMAN	DDB1 and CUL4 associated factor 7	207					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)	18						GTTTGACCTCCGCCATCTAGA	0.562000													19	36					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669197	234669197	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234669197G>A	ENST00000360418.3	+	1	264	c.264G>A	c.(262-264)gtG>gtA	p.V88V	UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A1_ENST00000305208.5_Silent_p.V88V|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A3_ENST00000482026.1_Intron			P22309	UD11_HUMAN		88					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	GGGAGGATGTGAAAGAGTCTT	0.418000													59	160					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13150667	13150667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:13150667G>A	ENST00000319217.7	-	25	3720	c.3473C>T	c.(3472-3474)cCa>cTa	p.P1158L	MPDZ_ENST00000541718.1_Missense_Mutation_p.P1158L|MPDZ_ENST00000447879.1_Missense_Mutation_p.P1158L|MPDZ_ENST00000381015.4_Missense_Mutation_p.P1158L|MPDZ_ENST00000536827.1_Missense_Mutation_p.P1158L|MPDZ_ENST00000538841.1_Missense_Mutation_p.P50L|MPDZ_ENST00000381022.2_Missense_Mutation_p.P1158L|MPDZ_ENST00000546205.1_Missense_Mutation_p.P1172L	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1158	PDZ 7.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		GGATTTGCTTGGTTCTCTCCA	0.403000													15	34					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70555477	70555477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70555477G>A	ENST00000310961.5	+	25	4698	c.4280G>A	c.(4279-4281)gGa>gAa	p.G1427E	LRRC7_ENST00000415775.2_Missense_Mutation_p.G753E|LRRC7_ENST00000035383.5_Missense_Mutation_p.G1469E			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1469						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGTGGACAAGGAAATCCATTC	0.303000													23	77					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186026368	186026368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186026368C>T	ENST00000271588.4	+	46	7376	c.7147C>T	c.(7147-7149)Cct>Tct	p.P2383S	HMCN1_ENST00000367492.2_Missense_Mutation_p.P2383S	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2383					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCTTACAGCTCCTCCAAGCAT	0.368000													19	49					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085498	9085498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9085498G>A	ENST00000397910.4	-	1	6520	c.6317C>T	c.(6316-6318)cCa>cTa	p.P2106L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2106	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTGTTTCTGGATTTCTTTG	0.498000													50	152					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62586953	62586953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62586953C>T	ENST00000371158.2	+	38	5105	c.4991C>T	c.(4990-4992)tCc>tTc	p.S1664F	INADL_ENST00000472512.1_3'UTR	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1664					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TCAGATCCTTCCCAGAAAAAT	0.423000													28	73					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27528597	27528597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27528597G>A	ENST00000301904.3	+	6	1570	c.1550G>A	c.(1549-1551)gGg>gAg	p.G517E	SCARA3_ENST00000337221.4_Intron	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	517					response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		GGCCCTCGAGGGTTCCCAGGC	0.687000													5	20					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282624	152282624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152282624C>T	ENST00000368799.1	-	3	4773	c.4738G>A	c.(4738-4740)Gaa>Aaa	p.E1580K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1580	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCGCTGATTCTCCCTGGCCC	0.597000									Ichthyosis				127	261					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39817998	39817998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:39817998C>T	ENST00000553728.1	+	27	3883	c.3670C>T	c.(3670-3672)Cct>Tct	p.P1224S	CTAGE5_ENST00000557038.1_Missense_Mutation_p.P609S|CTAGE5_ENST00000280083.3_Missense_Mutation_p.P689S|CTAGE5_ENST00000341502.5_Missense_Mutation_p.P689S|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.P660S|CTAGE5_ENST00000341749.3_Missense_Mutation_p.P677S|CTAGE5_ENST00000553383.1_3'UTR|CTAGE5_ENST00000556148.1_Missense_Mutation_p.P614S|CTAGE5_ENST00000553352.1_Missense_Mutation_p.P660S|CTAGE5_ENST00000348007.3_Missense_Mutation_p.P646S|CTAGE5_ENST00000396165.4_Missense_Mutation_p.P660S|CTAGE5_ENST00000396158.2_Missense_Mutation_p.P694S																							AGCCACTGGCCCTGGCTTTGT	0.463000													47	360					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150488671	150488671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150488671G>A	ENST00000447204.2	-	7	1133	c.761C>T	c.(760-762)tCa>tTa	p.S254L	TMEM176B_ENST00000450753.2_Missense_Mutation_p.S217L|TMEM176B_ENST00000492607.1_Missense_Mutation_p.S254L|TMEM176B_ENST00000429904.2_Missense_Mutation_p.S254L|TMEM176B_ENST00000326442.5_Missense_Mutation_p.S254L|TMEM176B_ENST00000434545.1_Missense_Mutation_p.S254L	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	254					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGGGCACTGAATTCTCCCC	0.532000													19	62					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2411133	2411133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2411133G>A	ENST00000202625.2	+	11	1781	c.1720G>A	c.(1720-1722)Gaa>Aaa	p.E574K	TGM6_ENST00000381423.1_Missense_Mutation_p.E574K	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	574					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	TAAGTATAAAGAAGACCTGAC	0.458000													42	96					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28194205	28194205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:28194205G>A	ENST00000302326.4	-	1	3281	c.2327C>T	c.(2326-2328)tCt>tTt	p.S776F		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	776							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						GCCGCCACCAGAGCTGCCACC	0.736000			T	ETV6	"""AML, meningioma"""								5	8					0	0	1	0	0
VAV2	7410	broad.mit.edu	37	9	136635505	136635505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136635505G>A	ENST00000371851.1	-	25	2637	c.2312C>T	c.(2311-2313)tCc>tTc	p.S771F	VAV2_ENST00000406606.3_Missense_Mutation_p.S771F|VAV2_ENST00000371850.3_Missense_Mutation_p.S781F			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	781					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GTTACCTGGGGACCGGCTGGA	0.657000													13	44					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724857	49724857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49724857C>T	ENST00000551245.1	+	13	2340	c.2229C>T	c.(2227-2229)ctC>ctT	p.L743L	TROAP_ENST00000257909.3_Intron|TROAP_ENST00000547923.1_Intron			Q12815	TROAP_HUMAN	trophinin associated protein	0					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						GCCTGGCTCTCCCTCAGGAAG	0.607000													3	9					0	0	1	0	0
HMP19	51617	broad.mit.edu	37	5	173531281	173531281	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:173531281C>T	ENST00000303177.3	+	4	526	c.264C>T	c.(262-264)ttC>ttT	p.F88F	NSG2_ENST00000521585.1_Intron|NSG2_ENST00000521959.1_3'UTR	NM_015980.4	NP_057064.1																					GCATCGTGTTCCTGGTGGTTT	0.498000													30	57					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17699041	17699041	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:17699041C>T	ENST00000353383.1	+	3	3248	c.2779C>T	c.(2779-2781)Ctg>Ttg	p.L927L	RAI1_ENST00000261641.6_Silent_p.L927L	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	927						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		GTCCGTCATCCTGCTGGGCCC	0.632000													13	29					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221357	161221357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161221357C>T	ENST00000327928.4	+	4	1061	c.1061C>T	c.(1060-1062)cCt>cTt	p.P354L		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	354	C1q.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AAGCCATTTCCTCCTCCTAAC	0.498000													15	30					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97192281	97192281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97192281G>A	ENST00000371247.2	-	6	414	c.225C>T	c.(223-225)gcC>gcT	p.A75A	SORBS1_ENST00000361941.3_Silent_p.A75A|SORBS1_ENST00000393949.1_Silent_p.A75A|SORBS1_ENST00000354106.3_Silent_p.A75A|SORBS1_ENST00000371245.3_Silent_p.A75A|SORBS1_ENST00000371227.4_Silent_p.A75A|SORBS1_ENST00000371241.1_Silent_p.A43A|SORBS1_ENST00000607232.1_Silent_p.A43A|SORBS1_ENST00000306402.6_Silent_p.A75A|SORBS1_ENST00000371249.2_Silent_p.A43A|SORBS1_ENST00000371239.1_Silent_p.A43A|SORBS1_ENST00000347291.4_Silent_p.A75A|SORBS1_ENST00000277982.5_Silent_p.A75A|SORBS1_ENST00000474353.2_5'UTR|SORBS1_ENST00000353505.5_Silent_p.A75A|SORBS1_ENST00000371246.2_Silent_p.A75A			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	75					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		AGGAAGACGAGGCCCGGAGAG	0.527000													44	68					0	0	1	0	0
PTPN7	5778	broad.mit.edu	37	1	202128409	202128409	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202128409C>T	ENST00000309017.3	-	2	1210	c.437_splice	c.e2+1	p.R146_splice	PTPN7_ENST00000367279.4_Splice_Site_p.R80_splice|PTPN7_ENST00000543735.1_5'UTR|PTPN7_ENST00000544762.1_5'UTR|PTPN7_ENST00000308986.5_Splice_Site_p.R41_splice	NM_001199797.1|NM_002832.3	NP_001186726.1|NP_002823.3	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type 7	41	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|soft_tissue(1)|urinary_tract(1)	13						AAGATCTCACCTCTCCTGCAG	0.627000													6	41					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348028	140348028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348028G>A	ENST00000289269.5	+	1	2209	c.1677G>A	c.(1675-1677)ctG>ctA	p.L559L	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		559	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCACCACTGAGCAGCACTG	0.527000													26	75					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907685	12907685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12907685G>A	ENST00000317869.6	-	2	683	c.458C>T	c.(457-459)tCa>tTa	p.S153L		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						GCCCCTTCGTGAGGTGTTTCC	0.498000													66	395					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93119327	93119327	+	Missense_Mutation	SNP	C	C	T	rs142007147		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93119327C>T	ENST00000216487.7	+	6	2092	c.1933C>T	c.(1933-1935)Cgc>Tgc	p.R645C	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	645	Interaction with RAB5B.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding	p.R645C(1)		endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				GCAGGAGATTCGCACCATGAT	0.622000													15	37					0	0	1	0	0
DBT	1629	broad.mit.edu	37	1	100672014	100672014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100672014G>A	ENST00000370132.3	-	9	1209	c.1196C>T	c.(1195-1197)tCc>tTc	p.S399F		NM_001918.3	NP_001909.3	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase E2	399					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(1)	19		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TCCAATGTTGGAAAGAGTAAA	0.373000													55	159					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19747261	19747261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:19747261C>T	ENST00000507958.1	-	6	1303	c.313G>A	c.(313-315)Gat>Aat	p.D105N	CDH18_ENST00000382275.1_Missense_Mutation_p.D105N|CDH18_ENST00000274170.4_Missense_Mutation_p.D105N|CDH18_ENST00000502796.1_Missense_Mutation_p.D105N|CDH18_ENST00000511273.1_Missense_Mutation_p.D105N|CDH18_ENST00000506372.1_Missense_Mutation_p.D105N			Q13634	CAD18_HUMAN	cadherin 18, type 2	105	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.D104_D105>EY(2)|p.D105Y(2)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CCCGTGGTATCGTCAATGATA	0.438000													28	86					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651679	1651679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1651679C>T	ENST00000399676.2	+	1	647	c.609C>T	c.(607-609)agC>agT	p.S203S		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	203	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCCTGTAGCTGCTTCTCAG	0.592000													57	178					0	0	1	0	0
SPATA22	84690	broad.mit.edu	37	17	3346535	3346535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3346535G>A	ENST00000573128.1	-	8	1316	c.833C>T	c.(832-834)cCa>cTa	p.P278L	SPATA22_ENST00000572969.1_Missense_Mutation_p.P278L|SPATA22_ENST00000268981.5_Intron|SPATA22_ENST00000575375.1_Missense_Mutation_p.P278L|SPATA22_ENST00000355380.4_Missense_Mutation_p.P235L|SPATA22_ENST00000541913.1_Missense_Mutation_p.P262L|SPATA22_ENST00000397168.3_Missense_Mutation_p.P278L			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	278										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						CGAATAATATGGGCCAGGTGT	0.353000													14	25					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96967005	96967005	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96967005G>A	ENST00000341686.3	+	4	569	c.444G>A	c.(442-444)aaG>aaA	p.K148K	C10orf129_ENST00000430183.1_5'UTR|C10orf129_ENST00000394005.3_Silent_p.K148K	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	148					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		TGACTGCCAAGAAAATTCGCT	0.463000													10	77					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234845968	234845968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234845968C>T	ENST00000355722.4	+	3	127	c.13C>T	c.(13-15)Ctt>Ttt	p.L5F	TRPM8_ENST00000324695.4_Intron|TRPM8_ENST00000433712.2_Intron|TRPM8_ENST00000409625.1_Intron			Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	0						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GAAATCCTTCCTTCCTGTCCA	0.438000													12	53					0	0	1	0	0
SLC44A1	23446	broad.mit.edu	37	9	108127887	108127887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:108127887C>T	ENST00000374720.3	+	11	1624	c.1377C>T	c.(1375-1377)atC>atT	p.I459I	SLC44A1_ENST00000343170.7_Silent_p.I251I|SLC44A1_ENST00000374723.1_Silent_p.I459I|SLC44A1_ENST00000374724.1_Silent_p.I459I	NM_080546.3	NP_536856.2	Q8WWI5	CTL1_HUMAN	solute carrier family 44 (choline transporter), member 1	459						integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	38					Choline(DB00122)	CGCGAATGATCCTTATGTATA	0.408000													31	100					0	0	1	0	0
GKN1	56287	broad.mit.edu	37	2	69204639	69204639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69204639G>A	ENST00000377938.2	+	2	130	c.67G>A	c.(67-69)Gga>Aga	p.G23R		NM_019617.3	NP_062563.3	Q9NS71	GKN1_HUMAN	gastrokine 1	23					digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						TGTCTTTGCTGGACTTCTTGG	0.373000													36	111					0	0	1	0	0
DHDH	27294	broad.mit.edu	37	19	49438278	49438278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49438278G>A	ENST00000221403.2	+	2	152	c.112G>A	c.(112-114)Gat>Aat	p.D38N	DHDH_ENST00000522614.1_Missense_Mutation_p.D38N|DHDH_ENST00000523250.1_Missense_Mutation_p.D38N	NM_014475.3	NP_055290.1	Q9UQ10	DHDH_HUMAN	dihydrodiol dehydrogenase (dimeric)	38					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			central_nervous_system(1)|large_intestine(3)|lung(3)|ovary(1)|soft_tissue(1)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		GGCGGCCCGCGATCTGAGCCG	0.637000													4	10					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60741965	60741965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60741965G>A	ENST00000303375.5	+	2	577	c.175G>A	c.(175-177)Ggc>Agc	p.G59S		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	59	Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GGAGGCCCAGGGCGGGCAGGT	0.617000													35	98					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906452	13906452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13906452G>A	ENST00000279593.3	-	3	1018	c.809C>T	c.(808-810)cCt>cTt	p.P270L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	270					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAACTCCGCAGGCACTGTGTC	0.547000													14	61					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26346380	26346380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26346380G>A	ENST00000335473.7	+	37	6046	c.5796G>A	c.(5794-5796)gaG>gaA	p.E1932E	MYO18B_ENST00000536101.1_Silent_p.E1932E|MYO18B_ENST00000407587.2_Silent_p.E1933E	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1932	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TGCAGCTGGAGGAAGCCAAGA	0.438000													6	24					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736281	12736281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:12736281G>A	ENST00000380682.1	+	16	3842	c.3336G>A	c.(3334-3336)ggG>ggA	p.G1112G		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1112					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CAGCAACAGGGAAAACCTTTC	0.507000													72	40					0	0	1	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047502	46047502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46047502G>A	ENST00000397911.3	+	1	463	c.414G>A	c.(412-414)ccG>ccA	p.P138P	TSPEAR_ENST00000323084.4_Intron|KRTAP10-9_ENST00000484861.1_Intron	NM_198690.2	NP_941963.2	P60411	KR109_HUMAN	keratin associated protein 10-9	138	25 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9						cctgccagccggcctgctgtg	0.612000													35	251					0	0	1	0	0
IRAK3	11213	broad.mit.edu	37	12	66611005	66611005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:66611005G>A	ENST00000261233.4	+	6	1064	c.643G>A	c.(643-645)Gtt>Att	p.V215I	IRAK3_ENST00000457197.2_Missense_Mutation_p.V154I	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	215	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		TGAGCTTGAAGTTTTACTACT	0.363000													167	658					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140564245	140564245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140564245C>T	ENST00000361016.2	+	1	3266	c.2111C>T	c.(2110-2112)tCg>tTg	p.S704L		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		704					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCCTCTTTTCGGTGCTCCTG	0.697000													79	139					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532053	50532053	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50532053C>T	ENST00000374144.3	+	3	1751	c.1463C>T	c.(1462-1464)tCt>tTt	p.S488F	C10orf71_ENST00000323868.4_Missense_Mutation_p.S488F			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	488										endometrium(1)	1						GAATGTCAGTCTCGAGACAGC	0.547000													4	25					0	0	1	0	0
CLC	1178	broad.mit.edu	37	19	40225045	40225045	+	Missense_Mutation	SNP	G	G	A	rs149971661	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40225045G>A	ENST00000221804.4	-	3	256	c.181C>T	c.(181-183)Cgt>Tgt	p.R61C		NM_001828.5	NP_001819.2	Q05315	LPPL_HUMAN	Charcot-Leyden crystal galectin	61	Galectin.				lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(2)|stomach(1)	12	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)		ATGACCACACGACGACCAAAG	0.493000													55	137					0	0	1	0	0
AARS	16	broad.mit.edu	37	16	70298899	70298899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70298899G>A	ENST00000261772.8	-	11	1597	c.1454C>T	c.(1453-1455)cCa>cTa	p.P485L		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	485					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	ATTGTACTTTGGGGAATCATC	0.517000													22	37					0	0	1	0	0
SBNO2	22904	broad.mit.edu	37	19	1119586	1119586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1119586G>A	ENST00000361757.3	-	13	1539	c.1302C>T	c.(1300-1302)agC>agT	p.S434S	SBNO2_ENST00000438103.2_Silent_p.S377S|SBNO2_ENST00000587024.1_Silent_p.S434S	NM_014963.2	NP_055778.2	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 (Drosophila)	434					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent					NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACCCAAGCGGCTCATGTAGA	0.647000													6	14					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57137380	57137380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57137380C>T	ENST00000263314.2	+	12	1138	c.1104C>T	c.(1102-1104)atC>atT	p.I368I		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	368					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity	p.I368M(1)		endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						CGCTGAAAATCGCGGCTTTGA	0.547000													5	49					0	0	1	0	0
IHH	3549	broad.mit.edu	37	2	219920427	219920427	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219920427G>A	ENST00000295731.5	-	3	737	c.738C>T	c.(736-738)ttC>ttT	p.F246F		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	246				F -> L (in Ref. 1; BAA33523).	cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCGGTCCAGGAAAATGAGCA	0.657000													23	57					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133543015	133543015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133543015G>A	ENST00000409261.1	-	14	1742	c.1369C>T	c.(1369-1371)Ctg>Ttg	p.L457L	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Silent_p.L457L	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	457							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GGGCTCCCCAGGTCAGCTGTT	0.473000													13	45					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158914789	158914789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158914789C>T	ENST00000368140.1	+	7	1561	c.1316C>T	c.(1315-1317)cCt>cTt	p.P439L	PYHIN1_ENST00000368138.3_Missense_Mutation_p.P430L|PYHIN1_ENST00000485134.1_3'UTR|PYHIN1_ENST00000392254.2_Missense_Mutation_p.P439L|PYHIN1_ENST00000392252.3_Missense_Mutation_p.P430L	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	439					cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					CTCAAGACTCCTCAGATGCCA	0.493000													39	133					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4432134	4432134	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4432134C>T	ENST00000301280.5	+	12	2234	c.2133C>T	c.(2131-2133)ttC>ttT	p.F711F	CHAF1A_ENST00000587368.1_3'UTR	NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	711	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCTGCTTCCTGGAGACCC	0.662000								Chromatin Structure					14	46					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3511995	3511995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3511995C>T	ENST00000356575.4	-	3	509	c.283G>A	c.(283-285)Ggc>Agc	p.G95S		NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	95	EMI.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TGCCTGTAGCCCATGTAGTAG	0.612000													8	77					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111146191	111146191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111146191G>A	ENST00000485317.1	-	3	1887	c.1214C>T	c.(1213-1215)cCg>cTg	p.P405L	KCNA2_ENST00000316361.4_Missense_Mutation_p.P405L|KCNA2_ENST00000369770.3_Intron|KCNA2_ENST00000440270.1_Missense_Mutation_p.P405L			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	405						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		GACAGGGACCGGTAAGGCAAT	0.488000													15	106					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10480303	10480303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10480303C>T	ENST00000382483.3	-	2	632	c.409G>A	c.(409-411)Gaa>Aaa	p.E137K	RP1L1_ENST00000329335.3_5'UTR	NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	137					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTGGGGCTTCACGCTGGCCT	0.602000													25	51					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088726	9088726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9088726G>A	ENST00000397910.4	-	1	3292	c.3089C>T	c.(3088-3090)cCa>cTa	p.P1030L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1030	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATAGAGCCTGGGCCATTCGT	0.478000													54	116					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100687	93100687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:93100687G>A	ENST00000544406.2	+	2	546	c.280G>A	c.(280-282)Gat>Aat	p.D94N	C12orf74_ENST00000397833.3_Missense_Mutation_p.D94N			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	94										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						AAGCCCAAAGGATTCTTCACA	0.572000													24	56					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52897398	52897398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52897398G>A	ENST00000261844.7	-	7	2544	c.2392C>T	c.(2392-2394)Cat>Tat	p.H798Y	FAM214A_ENST00000546305.2_Missense_Mutation_p.H805Y	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	798																	TCCAAGGAATGAAAATTATGT	0.333000													52	134					0	0	1	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237284	30237284	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:30237284G>A	ENST00000378988.4	+	2	688	c.587G>A	c.(586-588)tGg>tAg	p.W196*		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	196	MAGE.						protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						CTCAGTTCCTGGGACTTTCCC	0.488000													3	13					0	0	1	0	0
ATG16L1	55054	broad.mit.edu	37	2	234200865	234200865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234200865C>T	ENST00000392017.4	+	15	1779	c.1522C>T	c.(1522-1524)Cgt>Tgt	p.R508C	ATG16L1_ENST00000347464.5_Missense_Mutation_p.R345C|ATG16L1_ENST00000392020.4_Missense_Mutation_p.R489C|ATG16L1_ENST00000392018.1_Missense_Mutation_p.R525C|ATG16L1_ENST00000373525.5_Missense_Mutation_p.R329C	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	508					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GAGCTGCTCCCGTGATGACTT	0.478000													17	60					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151771802	151771802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:151771802C>T	ENST00000255262.3	-	4	1363	c.1198G>A	c.(1198-1200)Gaa>Aaa	p.E400K		NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	400					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GACATCTGTTCACTAGAGAGG	0.458000													43	107					0	0	1	0	0
TBC1D5	9779	broad.mit.edu	37	3	17208398	17208398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:17208398G>A	ENST00000253692.7	-	21	3619	c.1955C>T	c.(1954-1956)tCc>tTc	p.S652F	TBC1D5_ENST00000429383.4_Missense_Mutation_p.S652F|TBC1D5_ENST00000446818.2_Missense_Mutation_p.S674F|TBC1D5_ENST00000414318.2_5'UTR	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	652						intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						AAAACGCAGGGAACCTTTTAG	0.448000													18	37					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102183090	102183090	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:102183090C>T	ENST00000306176.1	+	7	904	c.804C>T	c.(802-804)ttC>ttT	p.F268F	ZPLD1_ENST00000491959.1_Silent_p.F252F|ZPLD1_ENST00000466937.1_Silent_p.F252F	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	252	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						ATGATCTTTTCCTTAGGTAAG	0.313000													35	90					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127685093	127685093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127685093G>A	ENST00000508053.1	-	29	3909	c.2935C>T	c.(2935-2937)Cat>Tat	p.H979Y	FBN2_ENST00000262464.4_Missense_Mutation_p.H979Y|FBN2_ENST00000508989.1_Missense_Mutation_p.H946Y			P35556	FBN2_HUMAN	fibrillin 2	979	EGF-like 14; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CACTCGCAATGAAAAGATCCC	0.478000													22	37					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3508653	3508653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3508653C>T	ENST00000315677.3	-	11	3081	c.2486G>A	c.(2485-2487)gGa>gAa	p.G829E	DLGAP1_ENST00000581527.1_Missense_Mutation_p.G829E|DLGAP1_ENST00000400145.2_Missense_Mutation_p.G527E|DLGAP1_ENST00000400149.3_Missense_Mutation_p.G519E|DLGAP1_ENST00000400150.3_Missense_Mutation_p.G545E|DLGAP1_ENST00000400147.2_Missense_Mutation_p.G527E|DLGAP1_ENST00000539435.1_Missense_Mutation_p.G537E|DLGAP1_ENST00000515196.2_Missense_Mutation_p.G829E|DLGAP1_ENST00000584874.1_Missense_Mutation_p.G829E|DLGAP1_ENST00000400155.1_Missense_Mutation_p.G535E|DLGAP1_ENST00000581699.1_Missense_Mutation_p.G535E|DLGAP1_ENST00000534970.1_Missense_Mutation_p.G513E	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	829					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				TCGGATTTTTCCTAGAACTGG	0.413000													12	23					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725545	140725545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140725545C>T	ENST00000253812.6	+	1	1945	c.1945C>T	c.(1945-1947)Cac>Tac	p.H649Y	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTCCAGGACCACGGCCAGCC	0.711000													26	112					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394679	164394679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164394679C>T	ENST00000280605.3	-	1	368	c.208G>A	c.(208-210)Gac>Aac	p.D70N		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	70						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ATGAACCGGTCGTTGTCCGGG	0.552000													9	31					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72498746	72498746	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72498746C>T	ENST00000373208.1	+	11	1757	c.1757_splice	c.e11+1	p.S586_splice	ADAMTS14_ENST00000373207.1_Splice_Site_p.S583_splice	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	583	TSP type-1 1.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						AACAACCCCTCGTGAGTGTGC	0.672000													13	24					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16327635	16327635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:16327635G>A	ENST00000244769.4	-	8	1843	c.907C>T	c.(907-909)Cgg>Tgg	p.R303W	ATXN1_ENST00000436367.1_Missense_Mutation_p.R303W	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	303					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association	p.R303W(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GTGGCCTCCCGAGGGACAAAG	0.662000													25	43					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52284496	52284496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:52284496C>T	ENST00000356297.4	-	19	3938	c.3838G>A	c.(3838-3840)Gat>Aat	p.D1280N	PXDNL_ENST00000543296.1_Missense_Mutation_p.D1280N	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1280					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTCAGGTAATCCTGTGGGTAT	0.522000													7	23					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57333046	57333046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57333046G>A	ENST00000326441.9	-	7	1005	c.642C>T	c.(640-642)gaC>gaT	p.D214D	PEG3_ENST00000423103.2_Silent_p.D214D|ZIM2_ENST00000593711.1_Silent_p.D89D|ZIM2_ENST00000601070.1_Silent_p.D89D|PEG3_ENST00000593695.1_Silent_p.D88D|PEG3_ENST00000598410.1_Silent_p.D89D|ZIM2_ENST00000599935.1_Silent_p.D89D|ZIM2_ENST00000391708.3_Silent_p.D89D|ZIM2_ENST00000221722.5_Silent_p.D89D	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	214					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AAGCCCTGGAGTCCCTGTCGT	0.507000													64	148					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617473	77617473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77617473G>A	ENST00000521891.2	+	2	1598	c.1150G>A	c.(1150-1152)Gga>Aga	p.G384R	ZFHX4_ENST00000050961.6_Missense_Mutation_p.G384R|ZFHX4_ENST00000455469.2_Missense_Mutation_p.G384R|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G384R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	384						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTTCTTAAAAGGAAGCGCGAG	0.517000										HNSCC(33;0.089)			15	53					0	0	1	0	0
ACTA1	58	broad.mit.edu	37	1	229568554	229568554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:229568554G>A	ENST00000366684.3	-	3	305	c.203C>T	c.(202-204)aCc>aTc	p.T68I	ACTA1_ENST00000366683.2_Missense_Mutation_p.T68I	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	68			T -> I (in NEM3).		muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GTACTTCAGGGTCAGGATACC	0.582000													31	79					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96213026	96213026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:96213026C>T	ENST00000324765.8	+	16	2161	c.1814C>T	c.(1813-1815)cCa>cTa	p.P605L	DIAPH2_ENST00000355827.4_Missense_Mutation_p.P605L|DIAPH2_ENST00000373049.4_Missense_Mutation_p.P605L|DIAPH2_ENST00000373061.3_Missense_Mutation_p.P605L|DIAPH2_ENST00000373054.4_Missense_Mutation_p.P601L			O60879	DIAP2_HUMAN	diaphanous-related formin 2	605	FH1.|Poly-Pro.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						GGACCTCCTCCACCACCACCC	0.517000													21	16					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109840226	109840226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109840226G>A	ENST00000357155.1	-	3	297	c.248C>T	c.(247-249)cCt>cTt	p.P83L	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	83	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		GATGGCTTGAGGTTTGGGCTT	0.587000													16	36					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6488466	6488466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6488466G>A	ENST00000377828.1	+	2	643	c.475G>A	c.(475-477)Gag>Aag	p.E159K		NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	159					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		GCTTCTCGTCGAGCACTACCC	0.642000													23	51					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41444953	41444953	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41444953C>T	ENST00000599198.1	+	0	618					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						GAAAACGCTTCCACTACCAAG	0.507000													15	31					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185851	127185851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:127185851G>A	ENST00000371124.3	-	1	531	c.335C>T	c.(334-336)tCt>tTt	p.S112F		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	112						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						AGGATTCAAAGAGGGCTCGGT	0.483000													133	98					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871400	51871400	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51871400G>A	ENST00000371497.5	+	2	2290	c.1403G>A	c.(1402-1404)aGg>aAg	p.R468K	TSHZ2_ENST00000329613.6_Missense_Mutation_p.R465K|TSHZ2_ENST00000603338.2_Missense_Mutation_p.R465K	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	468					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AAAAAAGAAAGGCCAGAGGAA	0.423000													32	130					0	0	1	0	0
RASA3	22821	broad.mit.edu	37	13	114773083	114773083	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:114773083C>T	ENST00000334062.7	-	18	1790		c.e18-1		RASA3_ENST00000389544.4_Splice_Site	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3						intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity	p.?(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			GATCCAAGAACTAAAGTTGGA	0.532000													4	47					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54420801	54420801	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54420801G>A	ENST00000474759.1	+	4	429	c.381_splice	c.e4+1	p.Q127_splice	CACNA2D3_ENST00000415676.2_Splice_Site_p.Q127_splice|CACNA2D3_ENST00000288197.5_Splice_Site_p.Q127_splice|CACNA2D3_ENST00000490478.1_Splice_Site_p.Q33_splice	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	127						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CAGACTTACAGGTAACTGATT	0.383000													5	15					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216497518	216497518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216497518C>T	ENST00000366943.2	-	7	1706	c.1320G>A	c.(1318-1320)caG>caA	p.Q440Q	USH2A_ENST00000307340.3_Silent_p.Q440Q|USH2A_ENST00000366942.3_Silent_p.Q440Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	440	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACTTGGAAAGCTGAAGACAGT	0.358000										HNSCC(13;0.011)			12	33					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159499093	159499093	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:159499093C>T	ENST00000389757.3	+	11	1916	c.1791C>T	c.(1789-1791)ctC>ctT	p.L597L	PKP4_ENST00000389759.3_Silent_p.L597L	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	597					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						TTCGAAACCTCGTTTTTGGCA	0.433000										HNSCC(62;0.18)			25	106					0	0	1	0	0
NAA60	79903	broad.mit.edu	37	16	3533403	3533403	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3533403C>T	ENST00000407558.4	+	6	681	c.378C>T	c.(376-378)acC>acT	p.T126T	NAA60_ENST00000577013.1_Intron|NAA60_ENST00000575076.1_Silent_p.T126T|NAA60_ENST00000570819.1_Intron|NAA60_ENST00000360862.5_Silent_p.T61T|NAA60_ENST00000572942.1_Intron|NAA60_ENST00000573580.1_Silent_p.T61T|NAA60_ENST00000570551.1_3'UTR|NAA60_ENST00000414063.2_Silent_p.T126T|NAA60_ENST00000421765.3_Intron|NAA60_ENST00000424546.2_Silent_p.T133T|LA16c-306E5.3_ENST00000574423.2_RNA|NAA60_ENST00000572584.1_Silent_p.T126T|LA16c-306E5.2_ENST00000575785.1_RNA|NAA60_ENST00000576916.1_Intron	NM_001083601.1	NP_001077070.1	Q9H7X0	NAT15_HUMAN	N(alpha)-acetyltransferase 60, NatF catalytic subunit	126	N-acetyltransferase.						N-acetyltransferase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)	7						ACATATCAACCACCGCCCAGG	0.468000													8	18					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59211264	59211264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59211264C>T	ENST00000302030.2	+	1	648	c.623C>T	c.(622-624)aCt>aTt	p.T208I		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						GTGGTGGTCACTGTCGGAGGA	0.527000													47	144					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596407	24596407	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24596407C>T	ENST00000535378.1	-	4	1110	c.468G>A	c.(466-468)aaG>aaA	p.K156K	KIAA0319_ENST00000378214.3_Silent_p.K165K|KIAA0319_ENST00000430948.2_Silent_p.K120K|KIAA0319_ENST00000543707.1_Silent_p.K165K|KIAA0319_ENST00000537886.1_Silent_p.K165K	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	165					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GCAAGAGGTCCTTCTCCAGCT	0.577000													22	52					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134920413	134920413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134920413G>A	ENST00000398015.3	+	12	2598	c.2228G>A	c.(2227-2229)cGg>cAg	p.R743Q	EPHB1_ENST00000493838.1_Missense_Mutation_p.R304Q	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	743	Protein kinase.		R -> Q (in a gastric adenocarcinoma sample; somatic mutation).			integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.R743Q(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TATGTGCATCGGGACCTGGCT	0.552000													33	183					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394440	164394440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164394440C>T	ENST00000280605.3	-	1	607	c.447G>A	c.(445-447)cgG>cgA	p.R149R		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	149						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GGCAGAACACCCGGTAGCTGG	0.532000													19	86					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092793	151092793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151092793G>A	ENST00000370335.1	+	3	924	c.657G>A	c.(655-657)gaG>gaA	p.E219E	MAGEA4_ENST00000276344.2_Silent_p.E219E|MAGEA4_ENST00000393921.1_Silent_p.E219E|MAGEA4_ENST00000370340.3_Silent_p.E219E|MAGEA4_ENST00000370337.4_Silent_p.E219E|MAGEA4_ENST00000360243.2_Silent_p.E219E|MAGEA4_ENST00000393920.1_Silent_p.E219E			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	219	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GCGCCTCTGAGGAGGAAATCT	0.552000													57	53					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33495271	33495271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33495271C>T	ENST00000268876.5	+	10	1440	c.1343C>T	c.(1342-1344)gCc>gTc	p.A448V	UNC45B_ENST00000433649.1_Missense_Mutation_p.A448V|UNC45B_ENST00000591048.1_Missense_Mutation_p.A448V|UNC45B_ENST00000378449.1_Missense_Mutation_p.A448V|UNC45B_ENST00000394570.2_Missense_Mutation_p.A448V	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	448					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				CTCATCCATGCCTCCACGAAG	0.557000													22	18					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56392911	56392911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56392911C>T	ENST00000301295.6	+	10	3365	c.2943C>T	c.(2941-2943)acC>acT	p.T981T	NLRP4_ENST00000346986.5_Silent_p.T925T|NLRP4_ENST00000587891.1_Silent_p.T906T	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	981							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTAACCTGACCATCACAGACG	0.478000													18	40					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141765557	141765557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141765557G>A	ENST00000475668.2	+	40	4750	c.4696G>A	c.(4696-4698)Gag>Aag	p.E1566K	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1566	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CGCTGAGTACGAGATGTGTGT	0.498000													18	40					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256942	16256942	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16256942C>T	ENST00000375759.3	+	11	4411	c.4207C>T	c.(4207-4209)Cga>Tga	p.R1403*		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1403					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGAAAGTTCTCGATTGTCTTT	0.418000													35	65					0	0	1	0	0
HEYL	26508	broad.mit.edu	37	1	40105220	40105220	+	Silent	SNP	C	C	T	rs139547686	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40105220C>T	ENST00000372852.3	-	1	397	c.78G>A	c.(76-78)ctG>ctA	p.L26L		NM_014571.3	NP_055386.1	Q9NQ87	HEYL_HUMAN	hes-related family bHLH transcription factor with YRPW motif-like	26					multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCCCTTACCTCAGCTGGCCCT	0.741000													6	15					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32138307	32138307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32138307C>T	ENST00000312561.4	+	4	4832	c.4418C>T	c.(4417-4419)cCa>cTa	p.P1473L	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		AAAAACGTGCCATGTGATTCT	0.398000													36	80					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070233	141070233	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:141070233G>A	ENST00000503395.1	+	0	1313																											AACGCTCCAAGGTCATCCTGT	0.607000													5	18					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11944573	11944573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11944573C>T	ENST00000256720.2	+	15	2023	c.1930C>T	c.(1930-1932)Ccc>Tcc	p.P644S	LPIN1_ENST00000404113.2_Missense_Mutation_p.P145S|LPIN1_ENST00000449576.2_Missense_Mutation_p.P729S|LPIN1_ENST00000425416.2_Missense_Mutation_p.P650S|LPIN1_ENST00000396099.1_Missense_Mutation_p.P686S|LPIN1_ENST00000396097.1_Missense_Mutation_p.P374S	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	644	C-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		GAAGAATGGCCCCAACGACGT	0.468000													21	66					0	0	1	0	0
TRBV5-6	28609	broad.mit.edu	37	7	142131446	142131446	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142131446C>T	ENST00000390375.2	-	0	349																											GGGCCGAGTCCCCCAGCAACA	0.517000													37	81					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23318846	23318846	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23318846G>A	ENST00000593635.1	+	3	402	c.131G>A	c.(130-132)gGt>gAt	p.G44D	ZNF730_ENST00000597761.2_Splice_Site					zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						AAACCCCCAGGTAGGTGACAG	0.363000													30	100					0	0	1	0	0
SSTR1	6751	broad.mit.edu	37	14	38679711	38679711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:38679711C>T	ENST00000267377.2	+	3	1734	c.1117C>T	c.(1117-1119)Ctg>Ttg	p.L373L		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	373					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	ACCTGAGAACCTGGAGTCCGG	0.662000													15	77					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21042517	21042517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21042517C>T	ENST00000261383.3	-	37	5288	c.5289G>A	c.(5287-5289)gtG>gtA	p.V1763V	DNAH3_ENST00000415178.1_Silent_p.V1763V	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1763	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACTCGTGGCTCACTTGGTCAA	0.522000													21	67					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65263415	65263415	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65263415C>T	ENST00000389722.3	-	10	1254	c.1201G>A	c.(1201-1203)Gaa>Aaa	p.E401K	SPTB_ENST00000389720.3_Missense_Mutation_p.E401K|SPTB_ENST00000389721.5_Missense_Mutation_p.E401K|SPTB_ENST00000556626.1_Missense_Mutation_p.E401K|SPTB_ENST00000542895.1_Missense_Mutation_p.E401K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	401					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TACTCAGCTTCCTCCAGGCTT	0.577000													12	47					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25457027	25457027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:25457027G>A	ENST00000278886.6	-	17	2973	c.2900C>T	c.(2899-2901)tCg>tTg	p.S967L	NINL_ENST00000422516.1_Intron	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	967					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding	p.S967L(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						TCCCCTGCACGAAGCGGCCGG	0.687000													10	56					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120369297	120369297	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120369297G>A	ENST00000602047.1	+	14	1544	c.432G>A	c.(430-432)cgG>cgA	p.R144R	PCDP1_ENST00000413369.3_Silent_p.R430R|PCDP1_ENST00000597189.1_3'UTR			Q4G0U5	PCDP1_HUMAN		430						cilium	calmodulin binding					Colorectal(110;0.196)					GCCATAAACGGGTTGTTCGCA	0.328000													13	71					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186338624	186338624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186338624C>T	ENST00000411641.2	+	7	1228	c.1009C>T	c.(1009-1011)Cgg>Tgg	p.R337W	AHSG_ENST00000273784.5_Missense_Mutation_p.R338W			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	337					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GTCGCACCCCCGGAAAACACG	0.607000													26	82					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199453	4199453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:4199453G>A	ENST00000296358.4	-	5	1132	c.1108C>T	c.(1108-1110)Cgg>Tgg	p.R370W		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	370					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTGTAAATCCGGATTCCAGCC	0.582000													31	68					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70349006	70349006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70349006G>A	ENST00000338508.4	-	24	2094	c.2095C>T	c.(2095-2097)Cac>Tac	p.H699Y	SHANK2_ENST00000449116.2_Missense_Mutation_p.H110Y|SHANK2_ENST00000357171.3_Missense_Mutation_p.H110Y|SHANK2_ENST00000449833.2_Missense_Mutation_p.H110Y|SHANK2_ENST00000423696.2_Missense_Mutation_p.H319Y|SHANK2_ENST00000409530.1_Missense_Mutation_p.H109Y|SHANK2_ENST00000409161.1_Missense_Mutation_p.H109Y			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	319					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACCTGCCTGTGGCCGACTTTG	0.577000													22	74					0	0	1	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145473840	145473840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145473840C>T	ENST00000323397.4	+	4	1805	c.512C>T	c.(511-513)cCt>cTt	p.P171L		NM_001039888.2	NP_001034977.1	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34A	171										endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	20	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GTGGAGGACCCTGCTCCCGCC	0.627000													15	80					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155792079	155792079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155792079G>A	ENST00000437809.1	-	4	1008	c.886C>T	c.(886-888)Cat>Tat	p.H296Y	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Missense_Mutation_p.H296Y|GON4L_ENST00000368331.1_Missense_Mutation_p.H296Y|GON4L_ENST00000271883.5_Missense_Mutation_p.H296Y			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	296					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTACTCACATGAAGGATGTTT	0.418000													49	100					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73040873	73040873	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73040873G>A	ENST00000604411.1	+	0	28834				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AACTGTGAAAGGAAGGCTTTT	0.373000													10	20					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14806731	14806731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14806731G>A	ENST00000380881.4	-	19	4020	c.3205C>T	c.(3205-3207)Cct>Tct	p.P1069S	FREM1_ENST00000422223.2_Missense_Mutation_p.P1068S|FREM1_ENST00000380880.3_Missense_Mutation_p.P1068S			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1068					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCAAACTGAGGAGGAGAAACC	0.448000													3	14					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32977057	32977057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32977057C>T	ENST00000340811.4	-	7	1704	c.1596G>A	c.(1594-1596)atG>atA	p.M532I	PKP2_ENST00000070846.6_Missense_Mutation_p.M576I	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	576					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CACATCTTCTCATCGCTTTTC	0.408000													31	66					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173883916	173883916	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173883916C>T	ENST00000367698.3	-	2	301	c.183G>A	c.(181-183)aaG>aaA	p.K61K	SERPINC1_ENST00000494024.1_5'UTR	NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	61					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	CCTCAGTTGCCTTCTTCTCCG	0.582000											OREG0013990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	166					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24873522	24873522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24873522G>A	ENST00000396432.2	-	26	6182	c.5696C>T	c.(5695-5697)tCt>tTt	p.S1899F		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1898					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GGTGCTGGAAGAACTGCCTGT	0.493000													47	107					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46326873	46326873	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46326873C>T	ENST00000397850.2	-	5	737	c.285G>A	c.(283-285)caG>caA	p.Q95Q	ITGB2_ENST00000397852.1_Silent_p.Q95Q|ITGB2_ENST00000302347.5_Silent_p.Q95Q|ITGB2_ENST00000397857.1_Silent_p.Q95Q|ITGB2_ENST00000355153.4_Silent_p.Q95Q|ITGB2_ENST00000397854.3_Silent_p.Q95Q			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	95					apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	ACAGCTGCTTCTGGCCCCCAT	0.617000													28	69					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101767275	101767275	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101767275C>T	ENST00000375001.3	+	9	1719	c.1296C>T	c.(1294-1296)gcC>gcT	p.A432A		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	432	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GTGGTGTGGCCCCCGGGGAGC	0.622000													15	64					0	0	1	0	0
PTPDC1	138639	broad.mit.edu	37	9	96860798	96860798	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96860798C>T	ENST00000375360.3	+	7	2128	c.1788C>T	c.(1786-1788)gcC>gcT	p.A596A	PTPDC1_ENST00000288976.3_Silent_p.A648A	NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	596							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						CGGCCAAAGCCCTAGCAAATT	0.388000													43	82					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175137	143175137	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143175137C>T	ENST00000408916.1	+	1	172	c.172C>T	c.(172-174)Ctg>Ttg	p.L58L	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	58					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					CCGCTTCTGCCTGCAGTTGGT	0.567000													22	104					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165349587	165349587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165349587G>A	ENST00000263915.3	-	14	2120	c.1582C>T	c.(1582-1584)Cct>Tct	p.P528S	GRB14_ENST00000543549.1_Missense_Mutation_p.P441S|GRB14_ENST00000497306.1_5'UTR	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	528	SH2.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						AACTTGCAAGGAAGAACGCCC	0.383000													16	62					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186338623	186338623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186338623C>T	ENST00000411641.2	+	7	1227	c.1008C>T	c.(1006-1008)ccC>ccT	p.P336P	AHSG_ENST00000273784.5_Silent_p.P337P			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	336					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		TGTCGCACCCCCGGAAAACAC	0.607000													28	86					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119053962	119053962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119053962C>T	ENST00000409109.1	+	10	3329	c.2742C>T	c.(2740-2742)ctC>ctT	p.L914L	NLRX1_ENST00000525863.1_Intron|NLRX1_ENST00000409265.4_Intron|NLRX1_ENST00000409991.1_Silent_p.L914L|NLRX1_ENST00000292199.2_Silent_p.L914L|NLRX1_ENST00000469103.2_3'UTR			Q86UT6	NLRX1_HUMAN	NLR family member X1	914	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CAGTGATCCTCAGTGAAGTCC	0.617000													9	74					0	0	1	0	0
FAS	355	broad.mit.edu	37	10	90770529	90770529	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90770529G>A	ENST00000355740.2	+	6	745	c.525G>A	c.(523-525)ggG>ggA	p.G175G	FAS_ENST00000352159.4_Silent_p.G175G|FAS_ENST00000313771.5_3'UTR|FAS_ENST00000357339.2_Intron|FAS_ENST00000355279.2_Silent_p.G175G	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	175					activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		CTAACTTGGGGTGGCTTTGTC	0.348000													69	306					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141894	29141894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29141894C>T	ENST00000377167.2	+	1	584	c.482C>T	c.(481-483)tCc>tTc	p.S161F		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						GCACTTCATTCCTCCTTTACT	0.463000													92	203					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683513	159683513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159683513G>A	ENST00000255030.5	-	2	580	c.477C>T	c.(475-477)tcC>tcT	p.S159S	CRP_ENST00000368111.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000368110.1_Intron|CRP_ENST00000437342.1_5'UTR|CRP_ENST00000473196.1_5'UTR	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	159	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	TCCCACCGAAGGAATCCTGCT	0.517000													126	335					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88472476	88472476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88472476C>T	ENST00000394480.1	-	17	2400	c.2079G>A	c.(2077-2079)gtG>gtA	p.V693V	NTRK3_ENST00000558676.1_Silent_p.V685V|NTRK3_ENST00000357724.2_Silent_p.V685V|NTRK3_ENST00000355254.2_Silent_p.V693V|NTRK3_ENST00000542733.2_Silent_p.V595V|NTRK3_ENST00000360948.2_Silent_p.V693V|NTRK3_ENST00000557856.1_Silent_p.V685V	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	693	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCCCAATCTTCACTAGCAGAT	0.562000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			12	160					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45839446	45839446	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45839446A>C	ENST00000311275.7	-	22	3774	c.3521T>G	c.(3520-3522)cTc>cGc	p.L1174R	ZMYND8_ENST00000471951.2_Missense_Mutation_p.L1222R|ZMYND8_ENST00000540497.1_Missense_Mutation_p.L1122R|ZMYND8_ENST00000458360.2_Missense_Mutation_p.L1042R|ZMYND8_ENST00000396281.4_Missense_Mutation_p.L1174R|ZMYND8_ENST00000360911.3_Missense_Mutation_p.L1123R|ZMYND8_ENST00000446994.2_Missense_Mutation_p.L1093R|ZMYND8_ENST00000352431.2_Missense_Mutation_p.L1148R|ZMYND8_ENST00000262975.4_Missense_Mutation_p.L1156R|ZMYND8_ENST00000355972.4_Missense_Mutation_p.L1202R|ZMYND8_ENST00000461685.1_Missense_Mutation_p.L1176R|ZMYND8_ENST00000372023.3_Missense_Mutation_p.L1124R|ZMYND8_ENST00000536340.1_Missense_Mutation_p.L1229R			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	1174	Interacts with PRKCB1.						protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TTTCGGGAGGAGGCTCTTCGT	0.537000													21	108					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60773266	60773266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:60773266G>A	ENST00000335712.6	-	2	452	c.225C>T	c.(223-225)ctC>ctT	p.L75L	BCL11A_ENST00000359629.5_Silent_p.L75L|BCL11A_ENST00000538214.1_Silent_p.L75L|BCL11A_ENST00000537768.1_5'UTR|BCL11A_ENST00000358510.4_Silent_p.L75L|BCL11A_ENST00000356842.4_Silent_p.L75L	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	75	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TTTCTAAGCAGAGGCTGCCAT	0.498000			T	IGH@	B-CLL								11	88					0	0	1	0	0
AQP12A	375318	broad.mit.edu	37	2	241631526	241631526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241631526G>A	ENST00000429564.1	+	2	258	c.195G>A	c.(193-195)ggG>ggA	p.G65G	AQP12A_ENST00000337801.4_Silent_p.G53G			Q8IXF9	AQ12A_HUMAN	aquaporin 12A	53						integral to membrane	transporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(7)	14		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		CCTGGGCTGGGGACTTTGGGC	0.697000													6	27					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100645220	100645220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100645220C>T	ENST00000471714.1	-	2	315	c.206G>A	c.(205-207)gGa>gAa	p.G69E	ABI3BP_ENST00000532144.1_5'UTR|ABI3BP_ENST00000495063.1_Missense_Mutation_p.G69E|ABI3BP_ENST00000284322.5_Missense_Mutation_p.G69E			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	69						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GCTGCCATATCCCAGGAGAAG	0.473000													14	70					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10293918	10293918	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10293918C>T	ENST00000403437.2	-	40	5761	c.5667G>A	c.(5665-5667)gaG>gaA	p.E1889E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1889					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TGGATTGTTCCTCCTAAGAAT	0.428000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				38	53					0	0	1	0	0
FAM65B	9750	broad.mit.edu	37	6	24865551	24865551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24865551C>T	ENST00000259698.4	-	7	717	c.542G>A	c.(541-543)cGg>cAg	p.R181Q	FAM65B_ENST00000510784.2_Missense_Mutation_p.R215Q|FAM65B_ENST00000378023.4_Missense_Mutation_p.R181Q|FAM65B_ENST00000538035.1_Missense_Mutation_p.R210Q|FAM65B_ENST00000540914.1_Missense_Mutation_p.R181Q	NM_014722.2	NP_055537.2	Q9Y4F9	FA65B_HUMAN	family with sequence similarity 65, member B	181					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	25						CTTGAAGCTCCGATTGATCTC	0.522000													28	59					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508120	37508120	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37508120G>A	ENST00000374660.1	+	40	3768	c.3669G>A	c.(3667-3669)agG>agA	p.R1223R	ANKRD30A_ENST00000602533.1_Silent_p.R1104R|ANKRD30A_ENST00000361713.1_Silent_p.R1104R			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1170						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TAACTAAAAGGGCATCTCAAT	0.333000													51	183					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538663	4538663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4538663G>A	ENST00000306390.6	-	2	793	c.333C>T	c.(331-333)ttC>ttT	p.F111F	LRG1_ENST00000586883.1_5'UTR|CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	111						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGCCGCAGGAATTCGGGCG	0.652000													13	43					0	0	1	0	0
ATP6V1C2	245973	broad.mit.edu	37	2	10911968	10911968	+	Silent	SNP	G	G	A	rs142569799	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:10911968G>A	ENST00000381661.3	+	7	583	c.474G>A	c.(472-474)ggG>ggA	p.G158G	ATP6V1C2_ENST00000272238.4_Silent_p.G158G	NM_144583.3	NP_653184.2	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	158					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		CTTTTAGGGGGAACCTCTTCA	0.537000													63	128					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794955	126794955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126794955C>T	ENST00000373615.4	+	5	1929	c.1190C>T	c.(1189-1191)cCc>cTc	p.P397L		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	397				GHEPHSPSQTTLTNLF -> AMSLTAPHKRLLPTFSNDSQP PHPTISLKKKLSLV (in Ref. 1; AAB08752).		nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						CCTCACAGCCCCTCACAAACG	0.488000													24	62					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003639	57003639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57003639G>A	ENST00000606794.1	-	1	1036	c.840C>T	c.(838-840)ccC>ccT	p.P280P		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	280						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						CAAAGTCACAGGGCCAGTGCA	0.562000													12	32					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55512153	55512153	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55512153G>A	ENST00000543010.1	+	13	3219	c.3076G>A	c.(3076-3078)Gaa>Aaa	p.E1026K	NLRP2_ENST00000263437.6_Missense_Mutation_p.E1023K|NLRP2_ENST00000537859.1_Missense_Mutation_p.E1004K|NLRP2_ENST00000391721.4_Missense_Mutation_p.E1002K|NLRP2_ENST00000448584.2_Missense_Mutation_p.E1026K|NLRP2_ENST00000339757.7_Missense_Mutation_p.E1004K|NLRP2_ENST00000538819.1_Missense_Mutation_p.E1002K|NLRP2_ENST00000427260.2_Missense_Mutation_p.E1003K	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	1026					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTTTAATGATGAACTCAATAA	0.388000													42	93					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211179661	211179661	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211179661C>T	ENST00000352451.3	-	1	253	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K		NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	36					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		TCAATTTTTTCTTCTTTGGGT	0.512000													86	219					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141052202	141052202	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141052202G>A	ENST00000239440.4	-	9	1367	c.1302C>T	c.(1300-1302)atC>atT	p.I434I	ARAP3_ENST00000508305.1_Silent_p.I356I|ARAP3_ENST00000513878.1_Silent_p.I96I	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	434	PH 2.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CGATGAAGCAGATCCCGATGC	0.642000													19	31					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119737566	119737566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119737566G>A	ENST00000313400.4	-	10	1910	c.1810C>T	c.(1810-1812)Ccg>Tcg	p.P604S	ASTN2_ENST00000361209.2_Missense_Mutation_p.P553S|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.P600S			O75129	ASTN2_HUMAN	astrotactin 2	604						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TCCACAGGCGGAACCACAAAG	0.552000													9	65					0	0	1	0	0
ICA1	3382	broad.mit.edu	37	7	8183561	8183561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:8183561C>T	ENST00000402384.3	-	9	1112	c.846G>A	c.(844-846)gaG>gaA	p.E282E	ICA1_ENST00000406470.2_Silent_p.E282E|ICA1_ENST00000265577.7_Silent_p.E281E|ICA1_ENST00000396675.3_Silent_p.E282E|ICA1_ENST00000422063.2_Silent_p.E282E|ICA1_ENST00000401396.1_Silent_p.E270E			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	282					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TTTTCTTCTTCTCTTCTTTCT	0.408000													22	40					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183717885	183717885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183717885G>A	ENST00000511685.1	+	27	7432	c.7309G>A	c.(7309-7311)Gaa>Aaa	p.E2437K	TENM3_ENST00000406950.2_Missense_Mutation_p.E2437K					teneurin transmembrane protein 3																		ACCTTCTTACGAACTTGTGAA	0.408000													7	20					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140938301	140938301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140938301C>T	ENST00000277549.5	+	21	3507	c.938C>T	c.(937-939)cCc>cTc	p.P313L	CACNA1B_ENST00000277551.2_Missense_Mutation_p.P1121L|CACNA1B_ENST00000371372.1_Missense_Mutation_p.P1121L|CACNA1B_ENST00000371363.1_Missense_Mutation_p.P1121L|CACNA1B_ENST00000545473.1_Missense_Mutation_p.P147L|CACNA1B_ENST00000371355.4_Missense_Mutation_p.P1122L|CACNA1B_ENST00000371357.1_Missense_Mutation_p.P1122L			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1121					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGGAGCGGCCCCCGGCCTATC	0.602000													74	158					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50252887	50252887	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50252887C>T	ENST00000420502.1	+	0	522							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	CCTCAGGGGTCGTGGGTGAGC	0.582000													26	74					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103032170	103032170	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103032170G>A	ENST00000306312.3	-	11	1393	c.1132C>T	c.(1132-1134)Ctg>Ttg	p.L378L	SLC26A5_ENST00000393723.1_Silent_p.L378L|SLC26A5_ENST00000393727.1_Silent_p.L378L|SLC26A5_ENST00000393729.1_Silent_p.L341L|SLC26A5_ENST00000393730.1_Silent_p.L378L|SLC26A5_ENST00000393735.2_Silent_p.L378L|SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000339444.6_Silent_p.L378L|SLC26A5_ENST00000432958.2_Silent_p.L378L	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	378					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CACAGTCCCAGGGCAATGAGC	0.438000													5	26					0	0	1	0	0
IL3RA	3563	broad.mit.edu	37	X	1499956	1499956	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1499956A>T	ENST00000331035.4	+	11	1370	c.1021A>T	c.(1021-1023)Atg>Ttg	p.M341L	IL3RA_ENST00000381469.2_Missense_Mutation_p.M263L	NM_001267713.1|NM_002183.3	NP_001254642.1|NP_002174.1	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha (low affinity)	341						integral to membrane|plasma membrane	interleukin-3 receptor activity			lung(1)|skin(2)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CATCCCTCACATGAAAGACCC	0.547000													95	207					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96134618	96134618	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96134618C>T	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		TGCAGCAGTCCATTGACCAAT	0.517000			T	TRA@	T-ALL								33	91					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62647983	62647983	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:62647983C>T	ENST00000337910.5	-	6	1780	c.1443G>A	c.(1441-1443)aaG>aaA	p.K481K	RHOBTB1_ENST00000357917.4_Silent_p.K481K	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	481					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AGAACGTTCCCTTGCTGAGAC	0.473000													15	30					0	0	1	0	0
PF4	5196	broad.mit.edu	37	4	74846987	74846987	+	Silent	SNP	C	C	T	rs4694		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74846987C>T	ENST00000296029.3	-	3	410	c.240G>A	c.(238-240)agG>agA	p.R80R		NM_002619.3	NP_002610.1	P02776	PLF4_HUMAN	platelet factor 4	80					cytokine-mediated signaling pathway|immune response|leukocyte chemotaxis|negative regulation of angiogenesis|negative regulation of apoptosis|negative regulation of cytolysis|negative regulation of megakaryocyte differentiation|negative regulation of MHC class II biosynthetic process|platelet activation|platelet degranulation|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of tumor necrosis factor production	extracellular space|platelet alpha granule lumen	chemokine activity|heparin binding			kidney(1)|lung(1)	2	Breast(15;0.00136)		all cancers(17;0.0034)|Lung(101;0.196)		Drotrecogin alfa(DB00055)	AGCAAATTTTCCTTCCATTCT	0.458000													20	55					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9934828	9934828	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9934828T>A	ENST00000396573.2	-	7	1771	c.1462A>T	c.(1462-1464)Aaa>Taa	p.K488*	GRIN2A_ENST00000404927.2_Nonsense_Mutation_p.K488*|GRIN2A_ENST00000562109.1_Nonsense_Mutation_p.K488*|GRIN2A_ENST00000330684.3_Nonsense_Mutation_p.K488*|GRIN2A_ENST00000396575.2_Nonsense_Mutation_p.K488*|GRIN2A_ENST00000535259.1_Nonsense_Mutation_p.K331*	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	488					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGTTAACTTTCTTGCCATGC	0.438000													57	116					0	0	1	0	0
PIF1	80119	broad.mit.edu	37	15	65108826	65108826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65108826G>A	ENST00000268043.4	-	12	1907	c.1813C>T	c.(1813-1815)Ccc>Tcc	p.P605S	PIF1_ENST00000559239.1_Missense_Mutation_p.P605S|PIF1_ENST00000333425.6_Missense_Mutation_p.P605S			Q9H611	PIF1_HUMAN	PIF1 5'-to-3' DNA helicase	605	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						AGCACACGGGGGTCACAGCGA	0.657000													45	160					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249996	52249996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52249996C>T	ENST00000595042.1	-	3	393	c.252G>A	c.(250-252)agG>agA	p.R84R	FPR1_ENST00000304748.4_Silent_p.R84R	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	84					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CCATGGCCTTCCTGACCATGA	0.517000													24	85					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541538	55541538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55541538G>A	ENST00000361760.1	+	1	625	c.625G>A	c.(625-627)Gag>Aag	p.E209K		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				CATATTCAATGAGGTGAGCAG	0.393000													31	143					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158607824	158607824	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158607824C>T	ENST00000368148.3	-	36	5368	c.5189_splice	c.e36+1	p.E1730_splice	SPTA1_ENST00000368147.3_Splice_Site_p.E1730_splice	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1730					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGCACATACTCTATCCAGGAT	0.403000													35	111					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56416316	56416316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56416316C>T	ENST00000588751.1	-	8	2634	c.2610G>A	c.(2608-2610)gaG>gaA	p.E870E	NLRP13_ENST00000342929.3_Silent_p.E870E			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	870							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ACTCCAGTCTCTCTAAGGCAC	0.413000													21	39					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102508054	102508054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102508054C>T	ENST00000360184.4	+	65	12249	c.12085C>T	c.(12085-12087)Cac>Tac	p.H4029Y	RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557551.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4029	AAA 6 (By similarity).		H -> Q (in dbSNP:rs10129889).		cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CGACCTGACCCACATTGTGGG	0.597000													10	89					0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121106698	121106698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:121106698C>T	ENST00000295228.3	+	2	518	c.472C>T	c.(472-474)Cgc>Tgc	p.R158C		NM_002193.2	NP_002184.2	P09529	INHBB_HUMAN	inhibin, beta B	158					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				CTCCCGGGTCCGCCTATACTT	0.557000													31	66					0	0	1	0	0
TNFSF11	8600	broad.mit.edu	37	13	43181040	43181040	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43181040C>T	ENST00000398795.2	+	5	1089	c.721C>T	c.(721-723)Cga>Tga	p.R241*	TNFSF11_ENST00000358545.2_Nonsense_Mutation_p.R241*|TNFSF11_ENST00000405262.2_Nonsense_Mutation_p.R241*|TNFSF11_ENST00000544862.1_Nonsense_Mutation_p.R241*|TNFSF11_ENST00000239849.6_Nonsense_Mutation_p.R314*	NM_003701.3	NP_003692.1	O14788	TNF11_HUMAN	tumor necrosis factor (ligand) superfamily, member 11	314					immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding			kidney(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	10		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TTTTAAAGTTCGAGATATAGA	0.408000													31	74					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200967678	200967678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200967678G>A	ENST00000332129.2	-	14	2227	c.1911C>T	c.(1909-1911)gcC>gcT	p.A637A	KIF21B_ENST00000461742.2_Silent_p.A637A|KIF21B_ENST00000360529.5_Silent_p.A637A|KIF21B_ENST00000422435.2_Silent_p.A637A	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	637					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						AAGTCAGGTCGGCCAGGTCCG	0.587000													28	63					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111426819	111426819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111426819G>A	ENST00000393934.3	+	2	780	c.210G>A	c.(208-210)gtG>gtA	p.V70V	PLCXD2_ENST00000477665.1_Silent_p.V70V	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	70	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						AGTCCCCAGTGGGGCCTGACC	0.493000													9	23					0	0	1	0	0
SPRYD3	84926	broad.mit.edu	37	12	53461987	53461987	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53461987G>A	ENST00000301463.4	-	7	881	c.795C>T	c.(793-795)atC>atT	p.I265I	SPRYD3_ENST00000547837.1_Silent_p.I302I	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	265										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						CAGGGTCCACGATCTCCACCT	0.612000													52	132					0	0	1	0	0
KCNIP4	80333	broad.mit.edu	37	4	20734318	20734318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20734318C>T	ENST00000382148.3	-	6	889	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	KCNIP4_ENST00000509207.1_Missense_Mutation_p.E148K|KCNIP4_ENST00000382149.4_5'UTR|KCNIP4_ENST00000447367.2_Missense_Mutation_p.E176K|KCNIP4_ENST00000382150.4_Missense_Mutation_p.E189K|KCNIP4_ENST00000359001.5_Missense_Mutation_p.E148K|KCNIP4_ENST00000382152.2_Missense_Mutation_p.E210K|PACRGL_ENST00000507634.1_Intron	NM_001035003.1	NP_001030175.1	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4	210	EF-hand 3.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(46;0.134)				AAAAATGTTTCAACGTGTTGT	0.363000													24	47					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7700763	7700763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7700763C>T	ENST00000572933.1	+	52	9455	c.7995C>T	c.(7993-7995)ttC>ttT	p.F2665F	DNAH2_ENST00000389173.2_Silent_p.F2665F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2665					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAGAAGCCTTCATGGGCATCA	0.552000													69	77					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160915040	160915040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160915040G>A	ENST00000368029.3	-	8	925	c.868C>T	c.(868-870)Cgt>Tgt	p.R290C	RP11-544M22.1_ENST00000356006.3_RNA|ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	290					signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCACACTGACGGGGTTTGCCC	0.527000													22	39					0	0	1	0	0
SENP2	59343	broad.mit.edu	37	3	185318607	185318607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185318607C>T	ENST00000296257.5	+	5	653	c.413C>T	c.(412-414)aCc>aTc	p.T138I	SENP2_ENST00000545472.1_Missense_Mutation_p.T128I|SENP2_ENST00000465201.1_3'UTR|SENP2_ENST00000427465.2_5'UTR	NM_021627.2	NP_067640.2	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific peptidase 2	138					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(3)	12	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GTGACAGTTACCCGAGATCAG	0.363000													41	202					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322440	55322440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55322440C>T	ENST00000314644.2	+	1	658	c.658C>T	c.(658-660)Ccc>Tcc	p.P220S		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TTTCCAGCTTCCCTTTTGTGG	0.478000										HNSCC(20;0.049)			10	49					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955839	51955839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51955839G>A	ENST00000321424.3	-	7	1360	c.1294C>T	c.(1294-1296)Ccc>Tcc	p.P432S	SIGLEC8_ENST00000430817.1_Missense_Mutation_p.P323S|SIGLEC8_ENST00000340550.5_Missense_Mutation_p.P339S	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	432					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ACAGCTGGGGGAGGCTTCTTC	0.592000													22	42					0	0	1	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315552	73315552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73315552C>T	ENST00000258098.6	-	3	1434	c.1194G>A	c.(1192-1194)gaG>gaA	p.E398E	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	398					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						CAAGCACTGCCTCTGAGCTGC	0.647000													18	75					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8006979	8006979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:8006979C>T	ENST00000344293.5	+	3	1712	c.1506C>T	c.(1504-1506)ccC>ccT	p.P502P		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	502					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CTCCCACTCCCGAACCTCTCC	0.443000													46	108					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719097	140719097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140719097G>A	ENST00000394576.2	+	1	559	c.559G>A	c.(559-561)Gat>Aat	p.D187N	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGGGAGCTGATGGGAACAA	0.567000													12	108					0	0	1	0	0
AVEN	57099	broad.mit.edu	37	15	34159851	34159851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34159851G>A	ENST00000306730.3	-	5	947	c.818C>T	c.(817-819)tCc>tTc	p.S273F		NM_020371.2	NP_065104.1	Q9NQS1	AVEN_HUMAN	apoptosis, caspase activation inhibitor	273					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	7		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		CTGCAGTGGGGAAGTGGGTTT	0.488000													57	93					0	0	1	0	0
NR4A2	4929	broad.mit.edu	37	2	157186322	157186322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:157186322G>A	ENST00000339562.4	-	3	739	c.377C>T	c.(376-378)tCg>tTg	p.S126L	NR4A2_ENST00000409108.2_Missense_Mutation_p.S126L|NR4A2_ENST00000426264.1_Missense_Mutation_p.S63L|NR4A2_ENST00000429376.1_Missense_Mutation_p.S63L|NR4A2_ENST00000409572.1_Missense_Mutation_p.S126L|NR4A2_ENST00000539077.1_Missense_Mutation_p.S137L	NM_006186.3	NP_006177.1	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	126	Gln-rich.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						CGTCGGGGGCGAGGAGGGCTT	0.622000													50	85					0	0	1	0	0
PAX5	5079	broad.mit.edu	37	9	36846859	36846859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:36846859G>A	ENST00000523241.1	-	7	857	c.848C>T	c.(847-849)tCc>tTc	p.S283F	PAX5_ENST00000520281.1_Intron|PAX5_ENST00000377852.2_Silent_p.F326F|PAX5_ENST00000446742.1_Silent_p.F260F|PAX5_ENST00000377853.2_Intron|PAX5_ENST00000523145.1_Intron|PAX5_ENST00000377847.2_Intron|PAX5_ENST00000358127.4_Silent_p.F360F|PAX5_ENST00000520154.1_Intron|PAX5_ENST00000414447.1_Silent_p.F317F|PAX5_ENST00000522003.1_Silent_p.F252F			Q02548	PAX5_HUMAN	paired box 5	292					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(11)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CCGGGTTGGGGAACCTCCAGG	0.627000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								9	21					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34038258	34038258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:34038258G>A	ENST00000382499.2	-	17	2256	c.2257C>T	c.(2257-2259)Cct>Tct	p.P753S	SYNJ1_ENST00000322229.7_Missense_Mutation_p.P714S|SYNJ1_ENST00000382491.3_Missense_Mutation_p.P709S|SYNJ1_ENST00000357345.3_Missense_Mutation_p.P714S|SYNJ1_ENST00000433931.2_Missense_Mutation_p.P753S	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	714	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						CTTACCATAGGAAAACTCAAT	0.348000													14	44					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117306422	117306422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117306422C>T	ENST00000321322.6	-	27	4995	c.4994G>A	c.(4993-4995)gGg>gAg	p.G1665E	DSCAML1_ENST00000527706.1_Missense_Mutation_p.G1395E	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1605					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CAGTGCCACCCCCAGTGTGGC	0.577000													31	61					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197446823	197446823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197446823C>T	ENST00000367400.3	+	12	4170	c.4035C>T	c.(4033-4035)ttC>ttT	p.F1345F	CRB1_ENST00000535699.1_Silent_p.F1321F|CRB1_ENST00000538660.1_Silent_p.F809F|CRB1_ENST00000544212.1_Silent_p.F826F|CRB1_ENST00000367399.2_Silent_p.F1233F	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1345					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCGACATTTTCACCACTATTG	0.438000													6	51					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468689	56468689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:56468689G>A	ENST00000288221.6	-	2	602	c.347C>T	c.(346-348)tCa>tTa	p.S116L		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	116						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		ATCTGTGTATGAAAGGACATC	0.512000													53	136					0	0	1	0	0
FCER1A	2205	broad.mit.edu	37	1	159273855	159273855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159273855G>A	ENST00000368115.1	+	4	313	c.214G>A	c.(214-216)Gaa>Aaa	p.E72K	FCER1A_ENST00000368114.1_Missense_Mutation_p.E39K	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	72	Ig-like 1.					integral to plasma membrane		p.E72Q(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CAGCCTTTCAGAAGAGACAAA	0.363000													39	94					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172582164	172582164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:172582164C>T	ENST00000534253.2	+	8	716	c.548C>T	c.(547-549)cCa>cTa	p.P183L	DYNC1I2_ENST00000397119.3_Missense_Mutation_p.P183L|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.P175L|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.P157L|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.P177L|DYNC1I2_ENST00000410079.3_Missense_Mutation_p.P175L|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.P157L|DYNC1I2_ENST00000409197.1_Missense_Mutation_p.P157L|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.P183L|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.P183L|DYNC1I2_ENST00000409317.1_Missense_Mutation_p.P177L			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	183					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			GCTCCTAAACCACCTATTGAA	0.254000													7	18					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280446	152280446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152280446G>A	ENST00000368799.1	-	3	6951	c.6916C>T	c.(6916-6918)Cat>Tat	p.H2306Y	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2306	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCTCTGCATGATGAGTGCCT	0.562000									Ichthyosis				155	460					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241976665	241976665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241976665G>A	ENST00000310397.8	+	6	940	c.940G>A	c.(940-942)Gaa>Aaa	p.E314K	SNED1_ENST00000405547.3_Missense_Mutation_p.E314K|SNED1_ENST00000342631.6_Missense_Mutation_p.E314K|SNED1_ENST00000401884.1_Missense_Mutation_p.E314K|AC005237.4_ENST00000458377.1_RNA	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	314	EGF-like 2.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		AGACGTGAACGAATGTGCCTC	0.627000													6	12					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35293219	35293219	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:35293219C>A	ENST00000408931.3	-	1	539	c.13G>T	c.(13-15)Gcg>Tcg	p.A5S		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	5						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						TTGGGGGACGCCGTGAACTCC	0.647000													20	56					0.00047179	0.000472406	1	1	0
CHRNA6	8973	broad.mit.edu	37	8	42612175	42612175	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42612175C>T	ENST00000276410.2	-	4	625	c.270G>A	c.(268-270)tgG>tgA	p.W90*	CHRNA6_ENST00000534622.1_Nonsense_Mutation_p.W75*|CHRNA6_ENST00000530869.1_5'UTR	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	90						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TATAATCATTCCAGATCTAAA	0.423000													6	83					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155630087	155630087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155630087G>A	ENST00000368340.5	-	10	2076	c.1968C>T	c.(1966-1968)gcC>gcT	p.A656A	YY1AP1_ENST00000404643.1_Silent_p.A518A|YY1AP1_ENST00000361831.5_Silent_p.A527A|YY1AP1_ENST00000359205.5_Silent_p.A527A|MSTO1_ENST00000452804.2_Intron|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000407221.1_Silent_p.A507A|YY1AP1_ENST00000295566.4_Silent_p.A584A|YY1AP1_ENST00000368330.2_Silent_p.A538A|YY1AP1_ENST00000368339.5_Silent_p.A676A|YY1AP1_ENST00000535662.1_Silent_p.A384A|YY1AP1_ENST00000355499.4_Silent_p.A538A|YY1AP1_ENST00000311573.5_Silent_p.A507A|YY1AP1_ENST00000347088.5_Silent_p.A538A	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TACAGCGAAAGGCCCTGGCTC	0.537000													55	114					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27746305	27746305	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27746305G>A	ENST00000264717.2	+	19	1940	c.1877G>A	c.(1876-1878)tGa>tAa	p.*626*	GCKR_ENST00000424318.2_Silent_p.*436*	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	0					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					GACGTTCAGTGAACCCATGTT	0.612000													16	45					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40035355	40035355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40035355G>A	ENST00000372857.3	-	5	1442	c.650C>T	c.(649-651)aCc>aTc	p.T217I	PABPC4_ENST00000372858.3_Missense_Mutation_p.T217I|RP11-69E11.8_ENST00000415255.1_RNA|PABPC4_ENST00000372856.3_Missense_Mutation_p.T217I|PABPC4_ENST00000372862.3_Missense_Mutation_p.T217I|PABPC4_ENST00000529216.1_Intron	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	217	RRM 3.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GACACTTAGGGTCTTACCTAT	0.438000													14	159					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5863040	5863040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5863040C>T	ENST00000329322.5	-	1	87	c.88G>A	c.(88-90)Gga>Aga	p.G30R	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Missense_Mutation_p.G34R	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGGGAATCCAATCCAGATG	0.448000													33	84					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554246	135554246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135554246C>T	ENST00000372146.4	+	2	1804	c.1240C>T	c.(1240-1242)Cac>Tac	p.H414Y	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	414					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GCTGAATGTTCACAATTCCCA	0.458000													49	121					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039402	31039402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:31039402C>T	ENST00000355537.3	+	4	3023	c.2876C>T	c.(2875-2877)cCc>cTc	p.P959L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	959					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GAGGAGAAACCCAGTGGCAAG	0.577000													53	151					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476983	20476983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20476983C>T	ENST00000573854.1	+	3	436	c.322C>T	c.(322-324)Cgt>Tgt	p.R108C	ACSM2A_ENST00000575690.1_Missense_Mutation_p.R108C|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.R108C|ACSM2A_ENST00000536134.1_5'UTR|ACSM2A_ENST00000424070.1_Missense_Mutation_p.R108C|ACSM2A_ENST00000417235.2_Missense_Mutation_p.R29C|ACSM2A_ENST00000396104.2_Missense_Mutation_p.R108C	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	108					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding	p.R108C(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GCGTGGGGATCGTGTGGCAGT	0.572000													18	40					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133779647	133779647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133779647G>A	ENST00000372338.4	-	7	1432	c.1190C>T	c.(1189-1191)tCa>tTa	p.S397L	FIBCD1_ENST00000253018.4_Intron|FIBCD1_ENST00000448616.1_Missense_Mutation_p.S397L|FIBCD1_ENST00000372337.2_Missense_Mutation_p.S239L	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	397	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GTTGTTCTCTGAATGGTCGCT	0.652000													27	99					0	0	1	0	0
TNRC6C	57690	broad.mit.edu	37	17	76089072	76089072	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76089072C>T	ENST00000335749.4	+	15	4589	c.4020C>T	c.(4018-4020)tcC>tcT	p.S1340S	TNRC6C_ENST00000541771.1_Silent_p.S1343S|TNRC6C_ENST00000588061.1_Silent_p.S1343S|TNRC6C_ENST00000588847.1_Silent_p.S1340S|TNRC6C_ENST00000544502.1_Silent_p.S1340S|TNRC6C_ENST00000301624.4_Silent_p.S1343S	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	1343					gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TTGATGACTCCTATGGCCGGT	0.498000													13	36					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28348673	28348673	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28348673C>T	ENST00000337532.5	-	15	1481		c.e15-1		MPP7_ENST00000540098.1_Splice_Site|MPP7_ENST00000375719.3_Splice_Site|MPP7_ENST00000445954.2_Splice_Site|MPP7_ENST00000375732.1_Splice_Site	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)						establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						CTGGTGGTATCTATGATTTAA	0.338000													23	71					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10689791	10689791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:10689791G>A	ENST00000302079.6	-	45	7019	c.7020C>T	c.(7018-7020)ctC>ctT	p.L2340L	PIEZO2_ENST00000538948.1_Silent_p.L297L|PIEZO2_ENST00000285141.4_Silent_p.L195L|PIEZO2_ENST00000580640.1_Silent_p.L2365L|PIEZO2_ENST00000503781.3_Silent_p.L2340L			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2340						integral to membrane	ion channel activity										AAAAGGGCACGAGGCGAAACC	0.562000													16	53					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31895859	31895859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31895859C>T	ENST00000456570.1	+	2	229	c.174C>T	c.(172-174)tcC>tcT	p.S58S	CFB_ENST00000477310.1_Silent_p.S58S|C2_ENST00000442278.2_Intron|C2_ENST00000452323.2_Intron|C2_ENST00000469372.1_Intron|C2_ENST00000299367.5_Silent_p.S58S|CFB_ENST00000556679.1_Silent_p.S58S|C2_ENST00000418949.2_Silent_p.S58S			P00751	CFAB_HUMAN	complement factor B	69	Sushi 1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TGTACCCATCCCCAGCATCAC	0.637000													8	36					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203708726	203708726	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203708726C>T	ENST00000357681.5	+	21	4485	c.3362C>T	c.(3361-3363)cCc>cTc	p.P1121L	ATP2B4_ENST00000391954.2_3'UTR|ATP2B4_ENST00000367218.3_3'UTR|ATP2B4_ENST00000341360.2_3'UTR|ATP2B4_ENST00000367219.3_3'UTR	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	1157					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATTCAGAAACCCTACAACCAA	0.483000													33	92					0	0	1	0	0
IFI44	10561	broad.mit.edu	37	1	79128395	79128395	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:79128395G>A	ENST00000370747.4	+	8	1205	c.1120G>A	c.(1120-1122)Gaa>Aaa	p.E374K	IFI44_ENST00000495254.1_3'UTR	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	374					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						GCAGCTAGAGGAAGTCCAAAG	0.343000													10	87					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14812856	14812856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14812856G>A	ENST00000380881.4	-	17	3665	c.2850C>T	c.(2848-2850)ttC>ttT	p.F950F	FREM1_ENST00000422223.2_Silent_p.F949F|FREM1_ENST00000380880.3_Silent_p.F949F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	949					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CTCTCTGAGAGAACTGATCCA	0.498000													25	172					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6206765	6206765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6206765C>T	ENST00000262450.3	-	10	1649	c.1550G>A	c.(1549-1551)gGg>gAg	p.G517E	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	517	Chromo 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GTAGGACAGCCCTGCCCACTT	0.652000													10	42					0	0	1	0	0
TRIM11	81559	broad.mit.edu	37	1	228584602	228584602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228584602G>A	ENST00000366699.3	-	5	1143	c.905C>T	c.(904-906)cCt>cTt	p.P302L	RP11-245P10.8_ENST00000602963.1_RNA|TRIM11_ENST00000493030.2_Intron|TRIM11_ENST00000284551.6_Intron|TRIM11_ENST00000460651.1_Intron			Q96F44	TRI11_HUMAN	tripartite motif containing 11	0	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	18		Prostate(94;0.0724)				GTCCTTGGCAGGTCCCCTCCT	0.622000													13	26					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73574719	73574719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73574719C>T	ENST00000224721.6	+	69	9769	c.9764C>T	c.(9763-9765)aCt>aTt	p.T3255I	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Missense_Mutation_p.T1010I	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	3250					calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CTGATACAGACTGAGCTGGAC	0.652000													7	25					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475031	16475031	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16475031G>A	ENST00000358432.5	-	3	819	c.665C>T	c.(664-666)tCc>tTc	p.S222F	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	222	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	AGTGGCCAGGGAAGGTGCATC	0.662000													13	49					0	0	1	0	0
SLC35E4	339665	broad.mit.edu	37	22	31042716	31042716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31042716G>A	ENST00000343605.4	+	2	1550	c.751G>A	c.(751-753)Gac>Aac	p.D251N	SLC35E4_ENST00000406566.1_Intron|SLC35E4_ENST00000300385.8_Intron	NM_001001479.2	NP_001001479.1	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	251	Leu-rich.					integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						CACTGCTGGCGACTCTCGCCT	0.667000													8	30					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49446130	49446130	+	Silent	SNP	C	C	T	rs149962060		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49446130C>T	ENST00000374201.3	-	8	1127	c.825G>A	c.(823-825)gcG>gcA	p.A275A	FRMPD2_ENST00000407470.4_Silent_p.A244A|FRMPD2_ENST00000305531.3_Silent_p.A251A	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	275					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding	p.A275A(1)		NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GCCTCCGGCCCGCCTGCTGGT	0.577000													20	61					0	0	1	0	0
RETNLB	84666	broad.mit.edu	37	3	108475956	108475956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108475956G>A	ENST00000295755.6	-	1	275	c.77C>T	c.(76-78)tCc>tTc	p.S26F		NM_032579.2	NP_115968.1	Q9BQ08	RETNB_HUMAN	resistin like beta	26					cell proliferation	extracellular region	hormone activity			endometrium(1)|kidney(3)|lung(10)|prostate(1)|skin(1)	16						GGAGTCTAAGGAACACTGAGT	0.532000													12	21					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49062078	49062078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:49062078C>T	ENST00000376265.2	-	47	5762	c.5701G>A	c.(5701-5703)Gct>Act	p.A1901T	CACNA1F_ENST00000323022.5_Missense_Mutation_p.A1890T|CACNA1F_ENST00000376251.1_Missense_Mutation_p.A1836T	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1901					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GGACTCACAGCCTCCACCAAG	0.622000													4	8					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84585980	84585980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84585980C>T	ENST00000262753.4	-	7	974	c.829G>A	c.(829-831)Gaa>Aaa	p.E277K	POF1B_ENST00000373145.3_Missense_Mutation_p.E277K	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	277							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TGCAAATGTTCTAATAAGCAG	0.363000													19	23					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793946	17793946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17793946C>T	ENST00000379472.3	+	2	1335	c.1305C>T	c.(1303-1305)atC>atT	p.I435I	KCNC1_ENST00000265969.6_Silent_p.I435I	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	435						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						TGCCCGTCATCGTGAACAATT	0.567000													26	82					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20975341	20975341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20975341C>T	ENST00000261383.3	-	53	9864	c.9865G>A	c.(9865-9867)Gag>Aag	p.E3289K	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3289					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATCCGAGTCTCGTCAATCTGC	0.498000													45	106					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28574438	28574438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:28574438C>T	ENST00000220562.4	+	3	1764	c.862C>T	c.(862-864)Ctc>Ttc	p.L288F	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	288						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		ACAGAACCTTCTCTATAACGT	0.522000													8	43					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61847951	61847951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61847951G>A	ENST00000280772.1	-	29	3685	c.3494C>T	c.(3493-3495)tCt>tTt	p.S1165F	ANK3_ENST00000503366.1_Missense_Mutation_p.S1166F|ANK3_ENST00000373827.2_Missense_Mutation_p.S1159F|ANK3_ENST00000355288.2_Missense_Mutation_p.S299F	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1165					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTCTGGGAAAGATGCTTGAAC	0.488000													31	132					0	0	1	0	0
NR1D2	9975	broad.mit.edu	37	3	24003559	24003559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:24003559C>T	ENST00000312521.4	+	5	928	c.609C>T	c.(607-609)ttC>ttT	p.F203F	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117.3	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	203					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						ACAGCCAGTTCAGTGGTCACT	0.458000													16	33					0	0	1	0	0
PNPLA5	150379	broad.mit.edu	37	22	44277460	44277460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44277460C>T	ENST00000216177.4	-	8	1309	c.1177G>A	c.(1177-1179)Gcc>Acc	p.A393T	PNPLA5_ENST00000593866.1_Missense_Mutation_p.A279T|PNPLA5_ENST00000597664.1_Missense_Mutation_p.A393T|PNPLA5_ENST00000381198.2_Missense_Mutation_p.A279T	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	393					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				AGGAGCTGGGCCTTGGTCCTG	0.662000													3	8					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3905638	3905638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3905638G>A	ENST00000450849.2	+	4	810	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	ATCAY_ENST00000398448.3_Missense_Mutation_p.E121K|ATCAY_ENST00000600960.1_Missense_Mutation_p.E115K|ATCAY_ENST00000301260.6_Missense_Mutation_p.E115K	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	115					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GAATGGCAACGAACTGGAGTG	0.577000													25	62					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30260457	30260457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30260457C>T	ENST00000359358.4	-	6	1782	c.1344G>A	c.(1342-1344)acG>acA	p.T448T		NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	448						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GCCATTCATTCGTTTCTAGGT	0.473000													36	78					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13753547	13753547	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13753547G>A	ENST00000265104.4	-	63	10771	c.10667C>T	c.(10666-10668)cCa>cTa	p.P3556L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3556					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTTTCCAAATGGAATTTTCCG	0.398000									Kartagener syndrome				44	116					0	0	1	0	0
CIRH1A	84916	broad.mit.edu	37	16	69184802	69184802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:69184802C>T	ENST00000563094.1	+	8	1031	c.997C>T	c.(997-999)Ccc>Tcc	p.P333S	CIRH1A_ENST00000352319.4_Missense_Mutation_p.P333S|CIRH1A_ENST00000314423.7_Missense_Mutation_p.P333S			Q969X6	CIR1A_HUMAN	cirrhosis, autosomal recessive 1A (cirhin)	333						nucleolus	protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(108;0.125)		AATCACCTTTCCCCACGTAAG	0.542000													18	61					0	0	1	0	0
PROP1	5626	broad.mit.edu	37	5	177419863	177419863	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:177419863A>T	ENST00000308304.2	-	3	836	c.528T>A	c.(526-528)ccT>ccA	p.P176P		NM_006261.4	NP_006252.3	O75360	PROP1_HUMAN	PROP paired-like homeobox 1	176					central nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(9)|stomach(1)	13	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGGCTGGGAAGGGAGGGCAT	0.622000													6	26					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120834	38120834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38120834C>T	ENST00000406386.3	+	7	2526	c.2271C>T	c.(2269-2271)tcC>tcT	p.S757S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	757					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CCAGAGCCTCCTCTCCTAACA	0.572000													38	76					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881021	142881021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142881021C>T	ENST00000446620.1	+	1	510	c.510C>T	c.(508-510)ttC>ttT	p.F170F		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	170					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					TTATTTCCTTCAGTCACAGCA	0.433000													18	59					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7230365	7230365	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7230365A>C	ENST00000379938.2	+	10	2570	c.2033A>C	c.(2032-2034)tAc>tCc	p.Y678S	RREB1_ENST00000349384.6_Missense_Mutation_p.Y678S|RREB1_ENST00000334984.6_Missense_Mutation_p.Y678S|RREB1_ENST00000379933.3_Missense_Mutation_p.Y678S	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	678					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ATCTGCGACTACATCGCCGCC	0.622000													8	60					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9038103	9038103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9038103G>A	ENST00000397910.4	-	8	36376	c.36173C>T	c.(36172-36174)tCc>tTc	p.S12058F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12060	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAGGATGTGGAAATCCCTGG	0.483000													4	3					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584496	7584496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7584496G>A	ENST00000379802.3	+	24	7342	c.7001G>A	c.(7000-7002)cGa>cAa	p.R2334Q	DSP_ENST00000418664.2_Missense_Mutation_p.R1735Q	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2334	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCTGCAGAACGAGCTGTCACT	0.463000													21	56					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55523612	55523612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55523612C>T	ENST00000219070.4	+	7	1565	c.1056C>T	c.(1054-1056)ccC>ccT	p.P352P	MMP2_ENST00000437642.2_Silent_p.P302P|MMP2_ENST00000543485.1_Silent_p.P276P|MMP2_ENST00000570308.1_Silent_p.P276P	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	352	Collagen-binding.|Fibronectin type-II 3.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GTGTCTTCCCCTTCACTTTCC	0.577000													60	141					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55782888	55782888	+	Missense_Mutation	SNP	G	G	A	rs34553661		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55782888G>A	ENST00000373965.2	-	20	2705	c.2311C>T	c.(2311-2313)Cgt>Tgt	p.R771C	PCDH15_ENST00000395445.1_Missense_Mutation_p.R771C|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.R769C|PCDH15_ENST00000395433.1_Missense_Mutation_p.R742C|PCDH15_ENST00000395430.1_Missense_Mutation_p.R764C|PCDH15_ENST00000373955.1_Missense_Mutation_p.R764C|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.R764C|PCDH15_ENST00000395438.1_Missense_Mutation_p.R764C|PCDH15_ENST00000409834.1_Missense_Mutation_p.R375C|PCDH15_ENST00000437009.1_Missense_Mutation_p.R693C|PCDH15_ENST00000320301.6_Missense_Mutation_p.R764C|PCDH15_ENST00000395432.2_Missense_Mutation_p.R727C	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	764	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GATGTGATACGAAAAAGATTA	0.368000										HNSCC(58;0.16)			18	47					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41545673	41545673	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41545673C>T	ENST00000396942.1	-	35	4342		c.e35+1		ANK1_ENST00000352337.4_Splice_Site|ANK1_ENST00000396945.1_Splice_Site|ANK1_ENST00000289734.7_Splice_Site|ANK1_ENST00000379758.2_Splice_Site|ANK1_ENST00000265709.8_Splice_Site|ANK1_ENST00000347528.4_Splice_Site			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic						axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCCCCACTCACCTGCCCAGCT	0.498000													54	183					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57257937	57257937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57257937C>T	ENST00000343433.6	-	2	629	c.549G>A	c.(547-549)agG>agA	p.R183R	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	183										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CCAGCTTTTTCCTGGGTTCCT	0.478000													35	113					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149916067	149916067	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149916067G>A	ENST00000369135.3	-	12	2515	c.2221C>T	c.(2221-2223)Ccc>Tcc	p.P741S		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	741					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TCCTGGTGGGGGTAGGGTCGC	0.637000													24	40					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105180799	105180799	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105180799C>T	ENST00000392634.4	+	21	3412	c.3300C>T	c.(3298-3300)gcC>gcT	p.A1100A	INF2_ENST00000330634.7_Silent_p.A1100A	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	1100					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TGGAGGGGGCCTGGCCGGTGA	0.632000													5	20					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14106380	14106380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:14106380C>T	ENST00000235372.7	+	8	2946	c.2090C>T	c.(2089-2091)aCc>aTc	p.T697I	PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000311066.5_Missense_Mutation_p.T697I|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.T496I|PRDM2_ENST00000343137.4_Missense_Mutation_p.T496I	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	697						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CTTCTTCAAACCCAAGATAAA	0.398000													32	87					0	0	1	0	0
VTCN1	79679	broad.mit.edu	37	1	117712753	117712753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:117712753G>A	ENST00000369458.3	-	2	151	c.73C>T	c.(73-75)Ctc>Ttc	p.L25F	VTCN1_ENST00000463461.1_5'UTR|VTCN1_ENST00000539893.1_5'UTR|VTCN1_ENST00000328189.3_Missense_Mutation_p.L25F|VTCN1_ENST00000359008.4_Missense_Mutation_p.L28F	NM_024626.3	NP_078902.2	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation inhibitor 1	25						integral to membrane|plasma membrane				large_intestine(7)|lung(4)|upper_aerodigestive_tract(1)	12	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		CCAATGATGAGTGCAATTGCT	0.398000													50	115					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162280578	162280578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:162280578G>A	ENST00000389554.3	+	6	2206	c.1889G>A	c.(1888-1890)gGg>gAg	p.G630E	AC009487.5_ENST00000505579.1_RNA|TBR1_ENST00000410035.1_Missense_Mutation_p.G343E	NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	630						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						AGCGACTCGGGGATTTACGAG	0.687000													3	15					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11414274	11414274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:11414274G>A	ENST00000259089.4	+	9	1472	c.880G>A	c.(880-882)Gag>Aag	p.E294K	BLK_ENST00000529894.1_Missense_Mutation_p.E223K|RP11-148O21.4_ENST00000528629.1_RNA	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	294	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TCTGCAGCACGAGCGGCTGGT	0.577000													17	49					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042346	74042346	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74042346G>A	ENST00000409561.1	+	3	1117	c.996G>A	c.(994-996)ggG>ggA	p.G332G		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	332										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						CTGAGCTTGGGGACATTTCAA	0.438000													16	37					0	0	1	0	0
YTHDF3	253943	broad.mit.edu	37	8	64099987	64099987	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:64099987T>C	ENST00000539294.1	+	4	1731	c.1415T>C	c.(1414-1416)tTt>tCt	p.F472S	YTHDF3_ENST00000542911.2_Missense_Mutation_p.F283S|YTHDF3_ENST00000521674.1_3'UTR|YTHDF3_ENST00000517371.1_Intron	NM_001277817.1|NM_001277818.1|NM_152758.4	NP_001264746.1|NP_001264747.1|NP_689971.4	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	473	YTH.											Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			AGTGGACATTTTTGTGGAGTG	0.443000													15	38					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89790008	89790008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89790008C>T	ENST00000568064.1	+	4	943	c.653C>T	c.(652-654)cCa>cTa	p.P218L	ZNF276_ENST00000443381.2_Silent_p.T299T|ZNF276_ENST00000446326.2_Missense_Mutation_p.P96L|ZNF276_ENST00000289816.5_Silent_p.T224T			Q8N554	ZN276_HUMAN	zinc finger protein 276	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GGGCTGAGACCAAGACCCTGC	0.697000													17	38					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159560422	159560422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:159560422G>A	ENST00000307765.5	+	14	1305	c.1054G>A	c.(1054-1056)Ggg>Agg	p.G352R	RXFP1_ENST00000343542.5_Missense_Mutation_p.G304R|RXFP1_ENST00000460056.2_Missense_Mutation_p.G271R|RXFP1_ENST00000470033.1_Missense_Mutation_p.G319R|RXFP1_ENST00000448688.2_Missense_Mutation_p.G247R	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	352						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CAGCCTAGAAGGGATTGAAAT	0.269000													18	46					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35284668	35284668	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:35284668G>A	ENST00000408931.3	-	4	1073	c.545_splice	c.e4-1	p.L183_splice		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	183						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						TGCACATAGAGCCTAAGAAAA	0.353000													9	31					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925637	27925637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:27925637C>T	ENST00000244623.1	+	1	619	c.619C>T	c.(619-621)Cat>Tat	p.H207Y		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TGAGCTCTTCCATCTAATACC	0.428000													42	228					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36273299	36273299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36273299C>T	ENST00000007510.4	+	13	1254	c.1110C>T	c.(1108-1110)atC>atT	p.I370I	ARHGAP33_ENST00000378944.5_Silent_p.I234I|ARHGAP33_ENST00000314737.5_Silent_p.I370I			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	370	Rho-GAP.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						GTGAGAGGATCCCGGAGCTGT	0.612000													24	84					0	0	1	0	0
RBM27	54439	broad.mit.edu	37	5	145641171	145641171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145641171C>T	ENST00000265271.5	+	13	2158	c.1992C>T	c.(1990-1992)aaC>aaT	p.N664N	RBM27_ENST00000506502.1_Silent_p.N609N	NM_018989.1	NP_061862.1	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	664	RRM.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(3)|endometrium(4)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTAAACAACCGATTCATTC	0.468000													52	142					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128140	83128140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:83128140C>T	ENST00000329312.4	+	4	461	c.424C>T	c.(424-426)Cca>Tca	p.P142S		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	142					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TGCAACAAATCCAGAATCCAA	0.328000													9	9					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14711348	14711348	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14711348C>A	ENST00000284268.6	-	12	1767	c.1437G>T	c.(1435-1437)gaG>gaT	p.E479D	ANKH_ENST00000535119.1_Missense_Mutation_p.E281D	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	479					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CTGTCACCTCCTCTGTCGGAG	0.532000													90	204					3.1737e-70	3.19717e-70	1	1	0
FAM163A	148753	broad.mit.edu	37	1	179782989	179782989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179782989C>T	ENST00000341785.4	+	5	565	c.169C>T	c.(169-171)Ccc>Tcc	p.P57S		NM_173509.2	NP_775780.1	Q96GL9	F163A_HUMAN	family with sequence similarity 163, member A	57						integral to membrane				endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)	15						TCCCACGCATCCCAGAGGCCC	0.662000													23	60					0	0	1	0	0
AKNA	80709	broad.mit.edu	37	9	117118261	117118261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117118261G>A	ENST00000307564.4	-	14	3163	c.3002C>T	c.(3001-3003)cCt>cTt	p.P1001L	AKNA_ENST00000374075.5_Missense_Mutation_p.P920L|AKNA_ENST00000374088.3_Missense_Mutation_p.P1001L|AKNA_ENST00000223791.3_Missense_Mutation_p.P461L	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1001					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						CTGCCGGAGAGGCCCACTTGG	0.612000													28	39					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160113175	160113175	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:160113175G>A	ENST00000327245.5	-	6	1227	c.381C>T	c.(379-381)ttC>ttT	p.F127F	CTC-529G1.1_ENST00000524198.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	127					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATGATGACGAACAGGACAA	0.423000													16	35					0	0	1	0	0
NIM1K	167359	broad.mit.edu	37	5	43246021	43246021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:43246021C>T	ENST00000512796.1	+	2	1643	c.144C>T	c.(142-144)ttC>ttT	p.F48F	NIM1_ENST00000326035.2_Silent_p.F48F			Q8IY84	NIM1_HUMAN		48							ATP binding|magnesium ion binding|protein serine/threonine kinase activity										TGACGCCCTTCGAGAAACTGA	0.582000													22	114					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1268709	1268709	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1268709G>T	ENST00000296820.5	-	7	2383	c.2326C>A	c.(2326-2328)Cct>Act	p.P776T	TERT_ENST00000310581.5_Silent_p.I836I|TERT_ENST00000508104.2_Missense_Mutation_p.P776T|TERT_ENST00000334602.6_Silent_p.I836I			O14746	TERT_HUMAN	telomerase reverse transcriptase	0	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCGTGGAGAGGATGGAGCCCT	0.652000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				12	41					0.00316338	0.00316566	1	1	0
UBE2J2	118424	broad.mit.edu	37	1	1203257	1203257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1203257G>A	ENST00000349431.6	-	2	335	c.116C>T	c.(115-117)tCg>tTg	p.S39L	UBE2J2_ENST00000348298.7_5'UTR|UBE2J2_ENST00000491779.1_Intron|UBE2J2_ENST00000360466.2_Missense_Mutation_p.S39L|UBE2J2_ENST00000347370.2_5'UTR|UBE2J2_ENST00000400929.2_Intron|UBE2J2_ENST00000400930.4_Missense_Mutation_p.S39L	NM_058167.2	NP_477515.2	Q8N2K1	UB2J2_HUMAN	ubiquitin-conjugating enzyme E2, J2	39					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity			cervix(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		GAGAATATTCGAAGGGAGGGG	0.632000													59	197					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113999622	113999622	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113999622G>A	ENST00000429538.3	-	6	758	c.564C>T	c.(562-564)atC>atT	p.I188I	AC016683.6_ENST00000333145.5_RNA|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000263335.7_Silent_p.I188I|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000451179.1_RNA|PAX8_ENST00000397647.3_Silent_p.I188I|PAX8_ENST00000348715.5_Silent_p.I188I|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000422956.1_RNA|PAX8_ENST00000263334.5_Silent_p.I188I	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	188					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						CAGGCTGAGCGATGCCCAGGA	0.617000			T	PPARG	follicular thyroid		Thyroid dysgenesis						9	19					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84800711	84800711	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:84800711G>C	ENST00000389394.3	+	12	2061	c.1924_splice	c.e12+1	p.D642_splice	DNAH6_ENST00000237449.6_Splice_Site_p.D642_splice|DNAH6_ENST00000398278.2_Splice_Site_p.D642_splice	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	642	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						TCAGGAACCTGGTAACTTGTC	0.363000													40	106					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19553778	19553778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:19553778G>A	ENST00000409832.3	+	1	414	c.362G>A	c.(361-363)gGa>gAa	p.G121E		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	121										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GGCCCTTGGGGAGACTACGAC	0.597000													60	359					0	0	1	0	0
SRD5A3	79644	broad.mit.edu	37	4	56225558	56225558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:56225558C>T	ENST00000264228.4	+	2	495	c.267C>T	c.(265-267)ttC>ttT	p.F89F	SRD5A3_ENST00000514398.1_3'UTR	NM_024592.4	NP_078868.1	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	89					androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor			cervix(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GGAATGGCTTCCTGCTTTGGT	0.463000													59	250					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	184009978	184009978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184009978C>T	ENST00000402825.3	+	19	2604	c.2604C>T	c.(2602-2604)tgC>tgT	p.C868C	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000357474.5_Silent_p.C796C|ECE2_ENST00000404464.3_Silent_p.C750C|ECE2_ENST00000359140.4_Silent_p.C721C	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	868	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACTTCGGCTGCCCTGTCGGCT	0.662000													10	68					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20851952	20851952	+	Silent	SNP	G	G	A	rs139781911	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20851952G>A	ENST00000262715.5	-	25	3700	c.3660C>T	c.(3658-3660)acC>acT	p.T1220T	TEP1_ENST00000556935.1_Silent_p.T1112T	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1220	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CACGCAGATAGGTACAGAGGC	0.592000													6	13					0	0	1	0	0
CASD1	64921	broad.mit.edu	37	7	94164787	94164787	+	Silent	SNP	C	C	T	rs146953436	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94164787C>T	ENST00000297273.4	+	8	1082	c.795C>T	c.(793-795)atC>atT	p.I265I		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	265						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AAGAAACCATCATGGAATCTT	0.338000													30	89					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113933979	113933979	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113933979G>A	ENST00000297405.5	-	10	1754	c.1508_splice	c.e10-1	p.L504_splice	CSMD3_ENST00000352409.3_Splice_Site_p.L504_splice|CSMD3_ENST00000343508.3_Splice_Site_p.L464_splice|CSMD3_ENST00000455883.2_Splice_Site_p.L400_splice	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	504	Sushi 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTTGATCCAAGGCTAAAGTTA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	57					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134163082	134163082	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:134163082C>T	ENST00000389887.5	+	9	3351	c.855C>T	c.(853-855)ttC>ttT	p.F285F	GLB1L3_ENST00000431683.2_Silent_p.F285F			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	285					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		AGGATACTTTCAATCAGCTTC	0.478000													12	30					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34888123	34888123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34888123C>T	ENST00000360581.1	+	8	1001	c.873C>T	c.(871-873)ttC>ttT	p.F291F	NPSR1_ENST00000381542.1_Silent_p.F225F|NPSR1_ENST00000381539.3_Silent_p.F291F|NPSR1_ENST00000359791.1_Silent_p.F291F|NPSR1_ENST00000531252.1_Silent_p.F280F	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	291						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	GTCCATACTTCCTGTTTGACA	0.493000													103	272					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159384	152159384	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:152159384C>T	ENST00000439251.1	-	2	1197	c.759G>A	c.(757-759)ccG>ccA	p.P253P	PNMA5_ENST00000361887.5_Silent_p.P253P|PNMA5_ENST00000535214.1_Silent_p.P253P|PNMA5_ENST00000452693.1_Silent_p.P253P	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	253					apoptosis					breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCAATCTTCGGAGAGGTCT	0.522000													45	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179599310	179599310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179599310G>A	ENST00000589042.1	-	52	15465	c.15241C>T	c.(15241-15243)Ctt>Ttt	p.L5081F	TTN_ENST00000342992.6_Missense_Mutation_p.L3837F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.L4764F|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4764	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGGCTCAAGAGTTTTGATG	0.368000													28	150					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4718406	4718406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4718406G>A	ENST00000302640.8	+	23	3193	c.2843G>A	c.(2842-2844)gGc>gAc	p.G948D	ITPR1_ENST00000456211.2_Missense_Mutation_p.G939D|ITPR1_ENST00000443694.2_Missense_Mutation_p.G948D|ITPR1_ENST00000357086.4_Missense_Mutation_p.G954D|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000423119.2_Missense_Mutation_p.G954D|ITPR1_ENST00000354582.6_Missense_Mutation_p.G963D	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	963					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GCCCCTGAAGGCAATGTGAAG	0.552000													12	23					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143049029	143049029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143049029G>A	ENST00000343257.2	+	23	3025	c.2938G>A	c.(2938-2940)Gag>Aag	p.E980K		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	980					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					ATCCACAGACGAGGAGGATGA	0.622000													27	96					0	0	1	0	0
UBXN6	80700	broad.mit.edu	37	19	4453501	4453501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4453501G>A	ENST00000301281.6	-	3	390	c.266C>T	c.(265-267)gCc>gTc	p.A89V	UBXN6_ENST00000394765.3_Missense_Mutation_p.A36V	NM_025241.2	NP_079517.1	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	89						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						GGTGGCTTCGGCTTGAAGTTC	0.632000													5	31					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418949	8418949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8418949G>A	ENST00000337907.3	-	21	4280	c.3646C>T	c.(3646-3648)Cgc>Tgc	p.R1216C	RERE_ENST00000377464.1_Missense_Mutation_p.R948C|RERE_ENST00000476556.1_Missense_Mutation_p.R662C|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.R1216C	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1216					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R1216C(1)		central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TCACTGAGGCGACCTTCATGC	0.642000													52	69					0	0	1	0	0
TCERG1L	256536	broad.mit.edu	37	10	133058644	133058644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:133058644G>A	ENST00000368642.4	-	4	819	c.734C>T	c.(733-735)gCc>gTc	p.A245V		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	245	Poly-Ala.									cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CATggcagcggcggcggcggt	0.667000													6	11					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207760774	207760774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207760774G>A	ENST00000367049.4	+	34	5574	c.5574G>A	c.(5572-5574)acG>acA	p.T1858T	CR1_ENST00000367052.1_Silent_p.T1408T|CR1_ENST00000367051.1_Silent_p.T1408T|CR1_ENST00000400960.2_Silent_p.T1408T|RP11-78B10.2_ENST00000596003.1_RNA|RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367053.1_Silent_p.T1408T	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1408	Sushi 29.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCAGTCCTACGATCCCAATTA	0.438000													25	56					0	0	1	0	0
HMG20A	10363	broad.mit.edu	37	15	77756657	77756657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77756657C>T	ENST00000381714.3	+	4	593	c.165C>T	c.(163-165)ctC>ctT	p.L55L	HMG20A_ENST00000336216.4_Silent_p.L55L	NM_018200.2	NP_060670.1	Q9NP66	HM20A_HUMAN	high mobility group 20A	55					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						TGGAGGATCTCTCTCAAGGTC	0.448000													29	86					0	0	1	0	0
SYT7	9066	broad.mit.edu	37	11	61291930	61291930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61291930C>T	ENST00000263846.4	-	6	1024	c.697G>A	c.(697-699)Gac>Aac	p.D233N	SYT7_ENST00000535826.1_Missense_Mutation_p.D352N|SYT7_ENST00000542836.1_Missense_Mutation_p.D277N|SYT7_ENST00000539008.1_Missense_Mutation_p.D516N|SYT7_ENST00000540677.1_Missense_Mutation_p.D308N|SYT7_ENST00000540831.1_5'UTR|SYT7_ENST00000542670.1_Missense_Mutation_p.D441N	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	233	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CCAATGGGGTCGTTGCGGCTG	0.547000													13	47					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158224974	158224974	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158224974G>A	ENST00000289429.5	+	2	692	c.159G>A	c.(157-159)caG>caA	p.Q53Q		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	53					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GTGATTTGCAGACTCATACCT	0.498000													20	78					0	0	1	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125233416	125233416	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:125233416C>T	ENST00000439075.1	-	0	1329					NR_026876.1																						TCCTGCAATTCCAGTCAATTT	0.393000													7	50					0	0	1	0	0
ENKUR	219670	broad.mit.edu	37	10	25279520	25279520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25279520C>T	ENST00000331161.4	-	4	685	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	ENKUR_ENST00000376363.1_Missense_Mutation_p.E156K	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	156						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						CATATGTATTCAGGTGTGACA	0.348000													6	55					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045401	142045401	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142045401C>T	ENST00000390392.3	+	0	150																											TTCTCTGTCTCCTGGGAGCGG	0.572000													50	151					0	0	1	0	0
MARC1	64757	broad.mit.edu	37	1	220971262	220971262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:220971262C>T	ENST00000366910.5	+	4	845	c.659C>T	c.(658-660)tCg>tTg	p.S220L	MARC1_ENST00000496110.1_3'UTR	NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	220	MOSC.						molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding	p.S220W(1)									TCTGAGGCGTCGCTGGCGGAT	0.438000													14	138					0	0	1	0	0
TRAF7	84231	broad.mit.edu	37	16	2222201	2222201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2222201C>T	ENST00000326181.6	+	8	617	c.485C>T	c.(484-486)cCc>cTc	p.P162L		NM_032271.2	NP_115647.2	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	162					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	23						GAGAAGTGTCCCGTGGACAAC	0.652000													5	22					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142437254	142437254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:142437254C>T	ENST00000378004.3	+	17	1835	c.1480C>T	c.(1480-1482)Cat>Tat	p.H494Y	ARHGAP26_ENST00000274498.4_Missense_Mutation_p.H494Y	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	494	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCCTTGTTCATCGGCTCCC	0.453000													41	129					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886094	23886094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23886094C>T	ENST00000355349.3	-	33	4789	c.4627G>A	c.(4627-4629)Gcc>Acc	p.A1543T		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1543					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCTCCAGGGCTGACTGCAGC	0.602000													28	73					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92428405	92428405	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92428405C>A	ENST00000362005.3	+	3	512	c.94C>A	c.(94-96)Ctt>Att	p.L32I	BRDT_ENST00000370389.2_Intron|BRDT_ENST00000399546.2_Missense_Mutation_p.L32I|BRDT_ENST00000394530.3_Missense_Mutation_p.L32I|BRDT_ENST00000402388.1_Missense_Mutation_p.L32I	NM_001242805.1	NP_001229734.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GACAAATCAACTTCAGTATCT	0.383000													18	176					3.52763e-06	3.53491e-06	1	1	0
ESRP1	54845	broad.mit.edu	37	8	95680211	95680211	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95680211G>A	ENST00000433389.2	+	10	1156	c.966G>A	c.(964-966)aaG>aaA	p.K322K	ESRP1_ENST00000358397.5_Silent_p.K322K|ESRP1_ENST00000454170.2_Silent_p.K322K|ESRP1_ENST00000423620.2_Silent_p.K322K	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	322					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						TTCTCTCCAAGGAAAATCAAG	0.463000													16	43					0	0	1	0	0
TMEM180	79847	broad.mit.edu	37	10	104230440	104230440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104230440C>T	ENST00000238936.4	+	5	507	c.270C>T	c.(268-270)tcC>tcT	p.S90S	TMEM180_ENST00000369931.3_Intron|TMEM180_ENST00000366277.2_Intron	NM_024789.3	NP_079065.2	Q14CX5	TM180_HUMAN	transmembrane protein 180	90						integral to membrane				breast(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|skin(1)	13		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCGGGCTCTCCTCAAGGGCTG	0.697000													32	135					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19178917	19178917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19178917G>A	ENST00000263200.10	-	27	4294	c.4222C>T	c.(4222-4224)Ctg>Ttg	p.L1408L	CLTCL1_ENST00000427926.1_Silent_p.L1408L|CLTCL1_ENST00000442042.2_5'UTR|CLTCL1_ENST00000353891.5_Silent_p.L1408L	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1408	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TAGAACTGCAGGGCTCTGTAA	0.532000			T	?	ALCL								40	74					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56044729	56044729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56044729G>A	ENST00000244728.5	-	3	684	c.287C>T	c.(286-288)tCa>tTa	p.S96L	COL21A1_ENST00000535941.1_Missense_Mutation_p.S96L|COL21A1_ENST00000370819.1_Missense_Mutation_p.S96L	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	96	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ATGTTCTCCTGAATCATAGCT	0.448000													9	36					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100454649	100454649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100454649C>T	ENST00000354161.3	+	5	733	c.608C>T	c.(607-609)tCc>tTc	p.S203F	SLC12A9_ENST00000415287.1_Missense_Mutation_p.S114F|SLC12A9_ENST00000428758.1_Missense_Mutation_p.S203F|SLC12A9_ENST00000275729.3_Missense_Mutation_p.S114F|SLC12A9_ENST00000540482.1_Missense_Mutation_p.S203F	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	203						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					GTCTCTGGCTCCCTGGCCTCT	0.652000													37	97					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691754	153691754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:153691754G>A	ENST00000304337.2	-	2	1223	c.403C>T	c.(403-405)Cgt>Tgt	p.R135C		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	135	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					GATTTAAAACGATCCAGCCAA	0.413000													72	59					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	10992758	10992758	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:10992758G>A	ENST00000304623.8	-	19	3305	c.3116C>T	c.(3115-3117)tCg>tTg	p.S1039L	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Missense_Mutation_p.S606L|CTNND2_ENST00000511377.1_Missense_Mutation_p.S948L|CTNND2_ENST00000503622.1_Missense_Mutation_p.S702L|CTNND2_ENST00000359640.2_Missense_Mutation_p.S981L	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1039					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GGTTGAAGACGAGGCTACAAA	0.542000													37	129					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697558	6697558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6697558C>T	ENST00000245907.6	-	21	2685	c.2593G>A	c.(2593-2595)Gaa>Aaa	p.E865K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	865					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGGAGTAGTTCCACCCTCACC	0.612000													9	37					0	0	1	0	0
OR1G1	8390	broad.mit.edu	37	17	3030699	3030699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3030699G>A	ENST00000328890.2	-	1	176	c.147C>T	c.(145-147)atC>atT	p.I49I		NM_003555.1	NP_003546.1	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G, member 1	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(3)|skin(3)	11						TGTCAGTAATGATGACTAGAA	0.522000													25	41					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5294911	5294911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5294911G>A	ENST00000546004.1	-	2	351	c.105C>T	c.(103-105)ctC>ctT	p.L35L	PROKR2_ENST00000217270.3_Silent_p.L35L			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	35						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CATCCATAGGGAGGTCATAAT	0.517000										HNSCC(71;0.22)			16	91					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604076	179604076	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179604076G>A	ENST00000589042.1	-	48	14108	c.13884C>T	c.(13882-13884)tcC>tcT	p.S4628S	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.S4265S|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Silent_p.S4457S|TTN_ENST00000359218.5_Silent_p.S4390S|TTN_ENST00000591111.1_Silent_p.S4311S|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4311	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTTGTTATGGATGTTGTGA	0.388000													7	51					0	0	1	0	0
LIPK	643414	broad.mit.edu	37	10	90492287	90492287	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90492287C>T	ENST00000404190.1	+	5	648	c.648C>T	c.(646-648)acC>acT	p.T216T		NM_001080518.1	NP_001073987.1	Q5VXJ0	LIPK_HUMAN	lipase, family member K	216					lipid catabolic process	extracellular region	hydrolase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	12		Colorectal(252;0.0381)		Colorectal(12;7.03e-05)|COAD - Colon adenocarcinoma(12;8.33e-05)		AACTAACAACCCTTTCCAGGC	0.363000													55	201					0	0	1	0	0
CYP19A1	1588	broad.mit.edu	37	15	51503250	51503250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51503250G>A	ENST00000396402.1	-	10	1420	c.1267C>T	c.(1267-1269)Cct>Tct	p.P423S	CYP19A1_ENST00000396404.4_Missense_Mutation_p.P423S|CYP19A1_ENST00000260433.2_Missense_Mutation_p.P423S|RP11-108K3.1_ENST00000559909.1_lincRNA|CYP19A1_ENST00000559878.1_Missense_Mutation_p.P423S	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	423					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	TACCTATAAGGAACCTATGAA	0.443000													12	39					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19047005	19047005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19047005G>A	ENST00000421369.3	+	7	1093	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K	TMC7_ENST00000569532.1_Missense_Mutation_p.E289K|TMC7_ENST00000561963.1_3'UTR|TMC7_ENST00000304381.5_Missense_Mutation_p.E289K	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	289						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						CAGGTCGGTGGAAGGATTCAA	0.438000													16	83					0	0	1	0	0
KRT32	3882	broad.mit.edu	37	17	39622349	39622349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39622349G>A	ENST00000225899.3	-	2	651	c.548C>T	c.(547-549)gCc>gTc	p.A183V		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	183	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				AACTCACTTGGCCCTGAAGTC	0.547000													5	71					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105415962	105415962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105415962C>T	ENST00000333244.5	-	7	5945	c.5826G>A	c.(5824-5826)gtG>gtA	p.V1942V	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1942						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CGGGGGCTGTCACTTCCGCCT	0.612000													102	250					0	0	1	0	0
MAN1B1	11253	broad.mit.edu	37	9	139983393	139983393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139983393C>T	ENST00000371589.4	+	3	474	c.401C>T	c.(400-402)cCc>cTc	p.P134L		NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	134					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		GCAAATCCACCCGTCTTACCA	0.473000													35	101					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23238964	23238964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23238964G>A	ENST00000400191.3	+	15	2742	c.2724G>A	c.(2722-2724)acG>acA	p.T908T	EPHB2_ENST00000374627.1_Silent_p.T903T|EPHB2_ENST00000374630.3_Silent_p.T908T|EPHB2_ENST00000374632.3_Silent_p.T909T	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	908					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TGGACCGCACGATCCCCGACT	0.617000													23	80					0	0	1	0	0
CEP112	201134	broad.mit.edu	37	17	63847976	63847976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:63847976C>T	ENST00000392769.2	-	21	2558	c.2340G>A	c.(2338-2340)atG>atA	p.M780I	CEP112_ENST00000541355.1_Missense_Mutation_p.M415I|CEP112_ENST00000580482.1_5'UTR|CEP112_ENST00000535342.2_Missense_Mutation_p.M780I|CEP112_ENST00000537949.1_Missense_Mutation_p.M738I	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	780						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						GCTCTATTTTCATCTTTTCTG	0.388000													73	167					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27505662	27505662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27505662G>A	ENST00000296098.4	+	1	333	c.63G>A	c.(61-63)gaG>gaA	p.E21E	TRIM54_ENST00000380075.2_Silent_p.E21E	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	21					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAACCTGGAGAAGCAGCTCA	0.592000													74	196					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256058	16256058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16256058C>T	ENST00000375759.3	+	11	3527	c.3323C>T	c.(3322-3324)cCc>cTc	p.P1108L		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1108					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AAGCCCATTCCCTCAAAACCA	0.463000													12	38					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572881	38572881	+	Missense_Mutation	SNP	C	C	T	rs147366609		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38572881C>T	ENST00000222345.6	+	3	1185	c.676C>T	c.(676-678)Cgc>Tgc	p.R226C		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	226					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GAACGAGTTCCGCAGCGAGCA	0.706000													21	70					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23329128	23329128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23329128G>A	ENST00000597761.2	+	4	1481	c.1282G>A	c.(1282-1284)Gaa>Aaa	p.E428K		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						CAAATGTGAAGAATGTGGCAG	0.388000													24	55					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045593	53045593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53045593C>T	ENST00000309680.3	-	1	355	c.334G>A	c.(334-336)Ggt>Agt	p.G112S		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	112	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		ccaccgaaaccaccaccactg	0.637000													4	14					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46246393	46246393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:46246393C>T	ENST00000334344.6	+	15	4659	c.4487C>T	c.(4486-4488)tCt>tTt	p.S1496F	ARID2_ENST00000444670.1_Missense_Mutation_p.S1106F|ARID2_ENST00000422737.1_Missense_Mutation_p.S1347F|ARID2_ENST00000457135.1_Missense_Mutation_p.S104F|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1496					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GTATCCCATTCTCCTGCCCTA	0.468000			"""N, S, F"""		hepatocellular carcinoma								31	112					0	0	1	0	0
PDIA2	64714	broad.mit.edu	37	16	335186	335186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:335186G>A	ENST00000219406.6	+	5	799	c.781G>A	c.(781-783)Gag>Aag	p.E261K	PDIA2_ENST00000462950.1_3'UTR|PDIA2_ENST00000404312.1_Missense_Mutation_p.E258K	NM_006849.2	NP_006840.2	Q13087	PDIA2_HUMAN	protein disulfide isomerase family A, member 2	261					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			breast(1)|central_nervous_system(4)|kidney(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	17		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				CCTGGTCACGGAGTTCAACAG	0.662000													6	43					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825119	4825119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4825119G>A	ENST00000380382.1	-	1	728	c.729C>T	c.(727-729)ttC>ttT	p.F243F	MMP26_ENST00000380390.1_Intron|OR52R1_ENST00000356069.2_Silent_p.F164F|MMP26_ENST00000477339.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TAGACACCATGAAGCAGAAGG	0.547000													12	78					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216077	140216077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140216077C>T	ENST00000525929.1	+	1	2109	c.2109C>T	c.(2107-2109)gcC>gcT	p.A703A	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Silent_p.A703A|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATCATCGCCATCTGCGCGG	0.612000													13	135					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159605610	159605610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159605610G>A	ENST00000337808.6	+	5	1687	c.1110G>A	c.(1108-1110)atG>atA	p.M370I	SCHIP1_ENST00000445224.2_Missense_Mutation_p.M127I|SCHIP1_ENST00000482804.1_Missense_Mutation_p.M143I|IQCJ-SCHIP1_ENST00000485419.1_Missense_Mutation_p.M446I|IQCJ-SCHIP1_ENST00000412423.2_Missense_Mutation_p.M357I|IQCJ-SCHIP1_ENST00000527095.1_Missense_Mutation_p.M138I|IQCJ-SCHIP1_ENST00000476809.1_Missense_Mutation_p.M419I|IQCJ-SCHIP1_ENST00000460298.1_Missense_Mutation_p.M330I	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		370						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						AAGCCAAAATGGCCCTTGCCA	0.453000													35	101					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904960	55904960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55904960G>A	ENST00000301529.1	-	1	234	c.235C>T	c.(235-237)Cct>Tct	p.P79S		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P79N(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AGCATTTTAGGGGCAATGACA	0.418000													56	102					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157667107	157667107	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157667107G>A	ENST00000368184.3	-	6	958	c.667C>T	c.(667-669)Cag>Tag	p.Q223*	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Nonsense_Mutation_p.Q223*	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	223	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					AATTGCAGCTGGACATCTGGC	0.587000													37	70					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64275848	64275848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:64275848C>T	ENST00000261891.3	-	2	203	c.198G>A	c.(196-198)gtG>gtA	p.V66V	DAPK2_ENST00000457488.1_Silent_p.V66V|DAPK2_ENST00000558482.1_5'UTR|DAPK2_ENST00000558069.1_Silent_p.V66V			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	66	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		CCTCCCGGCTCACACCGCGCC	0.622000													14	77					0	0	1	0	0
NPTN	27020	broad.mit.edu	37	15	73862580	73862580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73862580G>A	ENST00000351217.6	-	5	1595	c.677C>T	c.(676-678)cCt>cTt	p.P226L	NPTN_ENST00000345330.4_Missense_Mutation_p.P342L|NPTN_ENST00000545878.1_Missense_Mutation_p.P342L|NPTN_ENST00000542234.1_Missense_Mutation_p.P137L|NPTN_ENST00000562924.1_Missense_Mutation_p.P226L|NPTN_ENST00000563691.1_Missense_Mutation_p.P342L|NPTN_ENST00000287226.8_Missense_Mutation_p.L326F	NM_001161364.1|NM_017455.3	NP_001154836.1|NP_059429.1	Q9Y639	NPTN_HUMAN	neuroplastin	342	Ig-like 2.				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	13						TCCCAAGAAAGGCCAGAGTGG	0.527000													17	129					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86415993	86415993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86415993C>T	ENST00000361669.2	+	3	1984	c.885C>T	c.(883-885)ttC>ttT	p.F295F	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Silent_p.F167F|GRM3_ENST00000394720.2_Silent_p.F293F|GRM3_ENST00000439827.1_Silent_p.F295F	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	295					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ATGCCTCCTTCACCTGGGTGG	0.677000													29	55					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50222931	50222931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50222931G>A	ENST00000002829.3	+	14	1996	c.1512G>A	c.(1510-1512)gaG>gaA	p.E504E	SEMA3F_ENST00000434342.1_Silent_p.E473E|SEMA3F_ENST00000413852.1_Silent_p.E405E	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	504	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		AGGAGTTGGAGGAGCTCATGC	0.647000													8	23					0	0	1	0	0
MIR409	574413	broad.mit.edu	37	14	101531683	101531683	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101531683G>A	ENST00000362237.1	+	0	47					NR_029975.1																						TCTGGACGACGAATGTTGCTC	0.582000													37	44					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43859674	43859674	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43859674G>A	ENST00000378009.4	+	0	421				CD177_ENST00000607517.1_RNA|CD177_ENST00000378012.2_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane		p.M129I(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CAGATCCCATGATGGGAGCTG	0.517000													5	14					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460402	107460402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107460402C>T	ENST00000409382.3	-	2	642	c.32G>A	c.(31-33)cGa>cAa	p.R11Q	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.R11Q|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.R11Q	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	11					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.R11Q(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GAAAAGCATTCGTTGTCTCCA	0.507000													23	47					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940841	22940841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22940841C>T	ENST00000397104.3	-	5	1596	c.1597G>A	c.(1597-1599)Gaa>Aaa	p.E533K	ZNF99_ENST00000596209.1_Missense_Mutation_p.E624K					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CCACATTCTTCACATTTGTAG	0.383000													18	80					0	0	1	0	0
ALDH1A3	220	broad.mit.edu	37	15	101434167	101434167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101434167C>T	ENST00000329841.5	+	6	1078	c.546C>T	c.(544-546)ttC>ttT	p.F182F	RP11-66B24.4_ENST00000560351.1_RNA|ALDH1A3_ENST00000346623.6_Intron	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	182					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	AGTGGAACTTCCCCCTGCTGA	0.597000													32	188					0	0	1	0	0
RAI2	10742	broad.mit.edu	37	X	17819929	17819929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:17819929C>T	ENST00000545871.1	-	3	662	c.202G>A	c.(202-204)Ggc>Agc	p.G68S	RAI2_ENST00000360011.1_Missense_Mutation_p.G68S|RP3-389A20.4_ENST00000509491.2_Intron|RAI2_ENST00000331511.1_Missense_Mutation_p.G68S|RAI2_ENST00000451717.1_Missense_Mutation_p.G68S|RAI2_ENST00000415486.3_Intron	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	68					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					AGAGCCATGCCACTCTGAGAC	0.627000													53	53					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776758	5776758	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5776758C>T	ENST00000317254.3	+	1	836	c.788C>T	c.(787-789)tCc>tTc	p.S263F	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TCCTTCTTTTCCCACCGCTTT	0.478000													45	142					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	12933942	12933942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:12933942G>A	ENST00000379348.2	+	4	505	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	PHACTR1_ENST00000379350.1_Intron|PHACTR1_ENST00000332995.7_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	0						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TCTTGGGCTCGAACTGTGTTC	0.532000													46	90					0	0	1	0	0
USO1	8615	broad.mit.edu	37	4	76695903	76695903	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76695903C>T	ENST00000538159.1	+	8	636	c.636C>T	c.(634-636)ttC>ttT	p.F212F	USO1_ENST00000514213.2_Silent_p.F195F			O60763	USO1_HUMAN	USO1 vesicle transport factor	210	Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AAAATGCTTTCGAGAGACTAC	0.383000													39	108					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644428	169644428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169644428C>T	ENST00000428432.2	+	6	767	c.378C>T	c.(376-378)ttC>ttT	p.F126F	SAMD7_ENST00000335556.3_Silent_p.F126F	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	126										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GGATACCCTTCCTCTATGGCT	0.502000													32	76					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191941038	191941038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:191941038C>T	ENST00000392320.2	-	4	601	c.287G>A	c.(286-288)gGa>gAa	p.G96E	STAT4_ENST00000358470.4_Missense_Mutation_p.G96E	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	96					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			CATTGGATTTCCATGAAATTT	0.333000													25	93					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17579354	17579354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17579354G>A	ENST00000381861.3	-	1	376	c.57C>T	c.(55-57)atC>atT	p.I19I	MTUS1_ENST00000381869.3_Intron|MTUS1_ENST00000544260.1_Intron|MTUS1_ENST00000262102.6_Intron|MTUS1_ENST00000519263.1_Intron	NM_001001931.2	NP_001001931.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	0						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		AATTGATAAAGATTTTTGAAG	0.423000													32	46					0	0	1	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43678790	43678790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:43678790C>T	ENST00000374466.3	+	8	1764	c.1429C>T	c.(1429-1431)Ccg>Tcg	p.P477S		NM_018590.3	NP_061060.3	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 2	477					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GATTCGGACTCCGGTTCCTGG	0.478000													78	165					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109844602	109844602	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109844602G>A	ENST00000310903.5	+	9	1030	c.924G>A	c.(922-924)ggG>ggA	p.G308G	MYO1H_ENST00000542883.1_3'UTR|MYO1H_ENST00000431443.2_Silent_p.G308G			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						AGCTCCTGGGGGTCCACCCAT	0.438000													21	57					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98189039	98189039	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98189039C>T	ENST00000332650.5	+	1	716	c.619C>T	c.(619-621)Caa>Taa	p.Q207*		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGGTTCAGTTCAAGTCTTTAC	0.343000													53	148					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632737	122632737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122632737G>A	ENST00000195173.4	-	15	2403	c.2100C>T	c.(2098-2100)ggC>ggT	p.G700G	SEMA5B_ENST00000357599.3_Silent_p.G700G|SEMA5B_ENST00000451055.2_Silent_p.G754G			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	700	TSP type-1 1.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		CGCAGATGCGGCCCCCGTGGC	0.667000													30	72					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37617990	37617990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37617990C>T	ENST00000399151.3	+	19	3797	c.3712C>T	c.(3712-3714)Cgg>Tgg	p.R1238W		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1238					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CTACGACTCTCGGCGGGTCCT	0.582000													19	38					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8689378	8689378	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:8689378C>T	ENST00000378641.3	+	12	1704	c.1229C>T	c.(1228-1230)tCg>tTg	p.S410L	PLCB1_ENST00000378637.2_Missense_Mutation_p.S410L|PLCB1_ENST00000338037.6_Missense_Mutation_p.S410L	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	410	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ATTCTCCTTTCGTTTGAGAAC	0.358000													21	36					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48626890	48626890	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48626890G>A	ENST00000328333.8	-	17	2291	c.2184C>T	c.(2182-2184)tcC>tcT	p.S728S	COL7A1_ENST00000454817.1_Silent_p.S728S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	728	Fibronectin type-III 6.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AAACCAACTGGGATTTCTCTG	0.622000													29	58					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759246	121759246	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121759246G>A	ENST00000261367.7	+	6	2383	c.955G>A	c.(955-957)Gag>Aag	p.E319K	SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E319K|SNCAIP_ENST00000503116.2_Missense_Mutation_p.E319K|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E272K|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E272K|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000504884.2_Intron			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	272					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TCGAAAAGTTGAGAAGACAAC	0.488000													15	40					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186669961	186669961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:186669961G>A	ENST00000343098.5	+	17	16195	c.16195G>A	c.(16195-16197)Ggc>Agc	p.G5399S	FSIP2_ENST00000424728.1_Missense_Mutation_p.G5310S	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AGATATTATGGGCTTGGCTCT	0.308000													58	133					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16769358	16769358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:16769358C>T	ENST00000381323.3	-	3	250	c.30G>A	c.(28-30)agG>agA	p.R10R	FAM49A_ENST00000406434.1_Silent_p.R10R|FAM49A_ENST00000355549.2_Silent_p.R10R	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	10						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TTTCAATTTCCCTGGTAAGGA	0.333000													28	45					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103488537	103488537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103488537C>T	ENST00000358392.2	-	8	1359	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	COL11A1_ENST00000370096.3_Missense_Mutation_p.E336K|COL11A1_ENST00000512756.1_Intron|COL11A1_ENST00000353414.4_Missense_Mutation_p.E297K	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	336	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTAAATATTTCTTCAACTGGA	0.318000													12	36					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17107960	17107960	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17107960C>T	ENST00000443236.1	-	11	1228	c.1197G>A	c.(1195-1197)acG>acA	p.T399T	CPAMD8_ENST00000388925.4_Silent_p.T352T	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	352						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						ACTGCTTCCTCGTGTCCTTGG	0.637000													24	40					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939556	12939556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12939556G>A	ENST00000235349.5	-	4	1316	c.1246C>T	c.(1246-1248)Cct>Tct	p.P416S		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	416										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CGGGGGGCAGGATACAGCTCC	0.512000													71	642					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40773888	40773888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40773888C>T	ENST00000372748.3	-	17	972	c.876G>A	c.(874-876)ggG>ggA	p.G292G		NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	292	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			GGCCTGTGATCCCCTGGGGTC	0.627000													13	26					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110226283	110226283	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110226283G>A	ENST00000418703.2	-	12	2224	c.2130C>T	c.(2128-2130)ctC>ctT	p.L710L	TRPV4_ENST00000544971.1_Silent_p.L603L|TRPV4_ENST00000536838.1_Silent_p.L676L|TRPV4_ENST00000346520.2_Silent_p.L650L|TRPV4_ENST00000537083.1_Silent_p.L650L|TRPV4_ENST00000261740.2_Silent_p.L710L|TRPV4_ENST00000392719.2_Silent_p.L663L|TRPV4_ENST00000541794.1_Silent_p.L663L	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	710					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						GCATGTTGAGGAGCAGCACAA	0.602000													22	66					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3581927	3581927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3581927C>T	ENST00000315677.3	-	8	2506	c.1911G>A	c.(1909-1911)gaG>gaA	p.E637E	DLGAP1_ENST00000584874.1_Silent_p.E637E|DLGAP1_ENST00000581527.1_Silent_p.E637E|DLGAP1_ENST00000581699.1_Silent_p.E343E|DLGAP1_ENST00000515196.2_Silent_p.E637E|DLGAP1_ENST00000539435.1_Silent_p.E345E|DLGAP1_ENST00000400145.2_Silent_p.E335E|DLGAP1_ENST00000400150.3_Silent_p.E353E|DLGAP1_ENST00000400155.1_Silent_p.E343E|DLGAP1_ENST00000400147.2_Silent_p.E335E|DLGAP1_ENST00000400149.3_Silent_p.E327E|DLGAP1_ENST00000534970.1_Silent_p.E321E	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	637					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				TCTTCCTGTCCTCCgtggtga	0.493000													43	100					0	0	1	0	0
MORN5	254956	broad.mit.edu	37	9	124929162	124929162	+	Missense_Mutation	SNP	G	G	A	rs138145529		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:124929162G>A	ENST00000536616.1	+	2	201	c.163G>A	c.(163-165)Gac>Aac	p.D55N	MORN5_ENST00000373764.3_Missense_Mutation_p.D55N|MORN5_ENST00000486801.1_3'UTR			Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	55										endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	9						AAGCCAATACGACGCCATTTG	0.537000													5	34					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175299218	175299218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175299218C>T	ENST00000367674.1	-	21	4493	c.3785G>A	c.(3784-3786)gGc>gAc	p.G1262D	RP3-518E13.2_ENST00000569593.1_RNA|TNR_ENST00000263525.2_Missense_Mutation_p.G1262D	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1262	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACCCGCAGTGCCGTTGTAGCT	0.592000													21	52					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116955341	116955341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:116955341G>A	ENST00000265441.3	-	3	671	c.372C>T	c.(370-372)acC>acT	p.T124T	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	124					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TACAGGCCCTGGTGATGGCAA	0.473000													17	83					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277283	114277283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114277283C>T	ENST00000357077.4	+	38	7562	c.7509C>T	c.(7507-7509)gcC>gcT	p.A2503A	ANK2_ENST00000264366.6_Silent_p.A2470A|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2470					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CGGAAGTGGCCTCTGTGCGGT	0.532000													35	99					0	0	1	0	0
PRSS42	339906	broad.mit.edu	37	3	46874578	46874578	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46874578G>A	ENST00000447340.1	-	2	231	c.178C>T	c.(178-180)Cga>Tga	p.R60*	PRSS42_ENST00000429665.1_Nonsense_Mutation_p.R164*			Q7Z5A4	PRS42_HUMAN	protease, serine, 42	164					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	8						AGGTCATTTCGAATGGTTGTA	0.458000													32	52					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65425637	65425637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:65425637C>T	ENST00000330909.8	-	9	1186	c.1187G>A	c.(1186-1188)cGg>cAg	p.R396Q	MAGI1_ENST00000497477.2_Missense_Mutation_p.R396Q|MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000402939.2_Missense_Mutation_p.R396Q|MAGI1_ENST00000483466.1_Missense_Mutation_p.R396Q	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	396					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CTGCTTCTTCCGTTTGGCTTC	0.517000											OREG0015658	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	82					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842090	5842090	+	Silent	SNP	C	C	T	rs146871183		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5842090C>T	ENST00000317037.2	+	1	547	c.525C>T	c.(523-525)ttC>ttT	p.F175F	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGGGAACTTCATCCCCCACA	0.512000													45	134					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95085657	95085657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95085657G>A	ENST00000553947.1	+	6	1732	c.844G>A	c.(844-846)Gag>Aag	p.E282K	SERPINA3_ENST00000467132.1_Missense_Mutation_p.E257K|SERPINA3_ENST00000482740.1_Missense_Mutation_p.E39K|SERPINA3_ENST00000393080.4_Missense_Mutation_p.E257K|SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000393078.3_Missense_Mutation_p.E257K			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	257					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity	p.E257K(1)		NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		CTTCCGGGACGAGGAGCTGTC	0.502000													26	43					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48753420	48753420	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48753420G>A	ENST00000285238.8	+	22	3116	c.3036G>A	c.(3034-3036)ctG>ctA	p.L1012L	ABCC3_ENST00000510891.1_3'UTR	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1012	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCCTGAGGCTGGGCGTCTATG	0.557000													5	48					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540430	55540430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55540430G>A	ENST00000220676.1	+	4	4136	c.3988G>A	c.(3988-3990)Gat>Aat	p.D1330N		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1330					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGCCCAATTGATGAGACCTA	0.393000													34	132					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204948579	204948579	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204948579C>T	ENST00000367172.4	+	19	2396	c.2068C>T	c.(2068-2070)Ctc>Ttc	p.L690F	NFASC_ENST00000404076.1_Missense_Mutation_p.L669F|NFASC_ENST00000513543.1_Missense_Mutation_p.L686F|NFASC_ENST00000367171.4_Missense_Mutation_p.L675F|NFASC_ENST00000339876.6_Missense_Mutation_p.L690F|NFASC_ENST00000539706.1_Missense_Mutation_p.L686F|NFASC_ENST00000404907.1_Missense_Mutation_p.L686F|NFASC_ENST00000360049.4_Missense_Mutation_p.L686F|NFASC_ENST00000367170.4_Missense_Mutation_p.L690F|NFASC_ENST00000401399.1_Missense_Mutation_p.L690F|NFASC_ENST00000367169.4_Missense_Mutation_p.L690F|NFASC_ENST00000338586.6_Missense_Mutation_p.L690F|NFASC_ENST00000338515.6_Missense_Mutation_p.L690F			O94856	NFASC_HUMAN	neurofascin	690	Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTCAGCCGTCCTCCGGCTGTC	0.587000													36	150					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340447	121340447	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121340447C>T	ENST00000338040.4	+	3	585	c.171C>T	c.(169-171)ctC>ctT	p.L57L		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	57					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		ACCAGCTCCTCTGCCCTTTAG	0.587000													30	76					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703934	4703934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4703934G>A	ENST00000396950.3	-	2	247	c.8C>T	c.(7-9)tCc>tTc	p.S3F		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GAAGTTGCAGGAACTCATAGC	0.507000													17	31					0	0	1	0	0
ARMC4P1	101060171	broad.mit.edu	37	10	27577691	27577691	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27577691G>A	ENST00000576034.1	+	0	581																											CCATCGTCAGGAAGCAAGTGC	0.403000													8	51					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52400880	52400880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52400880G>A	ENST00000420323.2	+	36	6003	c.5742G>A	c.(5740-5742)gaG>gaA	p.E1914E		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1914	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGTACGGGGAGTTTGACCTCC	0.622000													37	97					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676172	123676172	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123676172C>T	ENST00000309154.2	-	1	923	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CTCAACACTTCCTGTACCTTC	0.408000													38	124					0	0	1	0	0
C1orf109	54955	broad.mit.edu	37	1	38155359	38155359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38155359G>A	ENST00000358011.4	-	2	383	c.194C>T	c.(193-195)gCc>gTc	p.A65V	C1orf109_ENST00000494120.1_5'UTR	NM_017850.1	NP_060320.1	Q9NX04	CA109_HUMAN	chromosome 1 open reading frame 109	65										lung(2)|prostate(2)	4		Myeloproliferative disorder(586;0.0393)				ATCTGGGAAGGCCCGAAGCGC	0.622000													41	81					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111090596	111090596	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:111090596G>A	ENST00000262839.2	-	6	2364	c.1446C>T	c.(1444-1446)ttC>ttT	p.F482F		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	482					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGGATATTGCGAAGAGTGCTT	0.483000													18	24					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47041164	47041164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47041164C>T	ENST00000450053.3	+	26	3927	c.3748C>T	c.(3748-3750)Ctc>Ttc	p.L1250F	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Intron	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1250	Leu-rich.						binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		ACAGCTGTCCCTCCAGGCTGA	0.607000													10	39					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104081960	104081960	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104081960C>T	ENST00000388887.2	+	28	3216	c.3012C>T	c.(3010-3012)ctC>ctT	p.L1004L		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1004	FAS1 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TGTCATTTCTCTCCGAAGCAG	0.378000													53	103					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105331392	105331392	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105331392C>T	ENST00000369780.4	+	3	871	c.462C>T	c.(460-462)gcC>gcT	p.A154A	NEURL_ENST00000369777.2_Silent_p.A137A	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		154	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GCTTCTGGGCCAAGGCGCTGC	0.622000													18	34					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163031436	163031436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163031436C>T	ENST00000188790.4	-	22	2117	c.1910G>A	c.(1909-1911)gGa>gAa	p.G637E	FAP_ENST00000443424.1_Missense_Mutation_p.G612E	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	637					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						AAGACCAGTTCCAGATGCAAG	0.408000													21	39					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210414908	210414908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210414908C>T	ENST00000367012.3	+	4	527	c.297C>T	c.(295-297)atC>atT	p.I99I	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	99							protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TGTAGACCATCTCAATTTTTG	0.328000													18	66					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71469630	71469630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71469630G>A	ENST00000322937.6	+	12	893	c.790G>A	c.(790-792)Gaa>Aaa	p.E264K	AMBN_ENST00000449493.2_Missense_Mutation_p.E249K	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	264					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			GAGTTCAGAAGAAGTGGCAGT	0.423000													15	49					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461415	48461415	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48461415G>A	ENST00000358536.4	-	11	2549	c.2280C>T	c.(2278-2280)tcC>tcT	p.S760S	PLXNB1_ENST00000456774.1_Intron|PLXNB1_ENST00000296440.6_Silent_p.S760S|PLXNB1_ENST00000358459.4_Intron|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	760	Pro-rich.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCTGGGAGGGGAGGGCTCCT	0.657000													7	18					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23019033	23019033	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23019033C>T	ENST00000327968.5	+	1	947	c.859C>T	c.(859-861)Caa>Taa	p.Q287*	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	287	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						TCTTGATTCTCAACCAATATC	0.418000													36	31					0	0	1	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176525	142176525	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142176525G>A	ENST00000390369.2	-	0	150																											TACCAATAAAGGGTTACATGA	0.547000													25	60					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186459485	186459485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186459485G>A	ENST00000265023.4	+	10	1512	c.1300G>A	c.(1300-1302)Gaa>Aaa	p.E434K	KNG1_ENST00000287611.2_Intron|KNG1_ENST00000447445.1_Intron|RP11-573D15.8_ENST00000599314.1_RNA|RP11-573D15.8_ENST00000354642.2_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	434	His-rich.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CTGGGGCCATGAAAAACAAAG	0.493000													20	54					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67577114	67577114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67577114C>T	ENST00000540839.3	+	14	2705	c.2485C>T	c.(2485-2487)Cct>Tct	p.P829S	FAM65A_ENST00000042381.4_Missense_Mutation_p.P809S|FAM65A_ENST00000379312.3_Missense_Mutation_p.P813S|FAM65A_ENST00000428437.2_Missense_Mutation_p.P823S|FAM65A_ENST00000422602.2_Missense_Mutation_p.P829S			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	813						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		TGGCCAGTTTCCTGAGCTGCA	0.672000													8	9					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2062038	2062038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2062038G>A	ENST00000280665.6	-	7	1147	c.1068C>T	c.(1066-1068)ttC>ttT	p.F356F	DCP1B_ENST00000397173.4_Silent_p.F254F|DCP1B_ENST00000540622.1_Silent_p.F230F|DCP1B_ENST00000541700.1_5'UTR	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	356					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.F356F(1)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			GAAGTTTCTCGAACAGGTTCT	0.532000													20	77					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36933525	36933525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36933525G>A	ENST00000373103.1	-	14	2309	c.1762C>T	c.(1762-1764)Cat>Tat	p.H588Y	CSF3R_ENST00000440588.2_Missense_Mutation_p.H588Y|CSF3R_ENST00000331941.5_Missense_Mutation_p.H588Y|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000373106.1_Missense_Mutation_p.H588Y|CSF3R_ENST00000361632.4_Missense_Mutation_p.H588Y|CSF3R_ENST00000373104.1_Missense_Mutation_p.H588Y|CSF3R_ENST00000418048.2_Missense_Mutation_p.H588Y|CSF3R_ENST00000338937.5_Missense_Mutation_p.H588Y	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	588	Fibronectin type-III 5.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TCCAGGCCATGGAGGACAAAG	0.627000													6	61					0	0	1	0	0
PUS10	150962	broad.mit.edu	37	2	61233692	61233692	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:61233692C>T	ENST00000316752.6	-	4	729	c.468_splice	c.e4+1	p.E156_splice	PUS10_ENST00000407787.1_Splice_Site_p.E156_splice	NM_144709.2	NP_653310.2	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	156					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)	22			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			ATGACCTTACCTCTCTTACAG	0.373000													5	70					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121981017	121981017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121981017G>A	ENST00000498619.1	+	4	1573	c.1135G>A	c.(1135-1137)Gaa>Aaa	p.E379K	CASR_ENST00000296154.5_Missense_Mutation_p.E379K|CASR_ENST00000490131.1_Missense_Mutation_p.E379K	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	379					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGGTCACGAAGAAAGTGGCGA	0.493000													27	54					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32927476	32927476	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:32927476G>A	ENST00000383763.4	+	3	1134	c.1071G>A	c.(1069-1071)gcG>gcA	p.A357A		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	357					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGATGAAGGCGAAGGTTGTGC	0.552000													31	57					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69816910	69816910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69816910G>A	ENST00000251566.4	-	1	599	c.569C>T	c.(568-570)tCc>tTc	p.S190F	UGT2A3_ENST00000420231.2_5'UTR	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	190						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGGTACATAGGAAAGTGGAGC	0.438000													21	48					0	0	1	0	0
KIAA0368	23392	broad.mit.edu	37	9	114145514	114145514	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114145514G>A	ENST00000259335.4	-	36	4313	c.4314C>T	c.(4312-4314)acC>acT	p.T1438T	KIAA0368_ENST00000374378.3_5'UTR|KIAA0368_ENST00000338205.5_Silent_p.T1260T	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						CTTCCGTCACGGTGCTCATCA	0.483000													10	13					0	0	1	0	0
SMAD5	4090	broad.mit.edu	37	5	135513139	135513139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135513139C>T	ENST00000545279.1	+	9	1726	c.1366C>T	c.(1366-1368)Cct>Tct	p.P456S	SMAD5_ENST00000514641.2_3'UTR|SMAD5_ENST00000545620.1_Missense_Mutation_p.P456S	NM_001001419.1|NM_005903.5	NP_001001419.1|NP_005894.3	Q99717	SMAD5_HUMAN	SMAD family member 5	457	MH2.				BMP signaling pathway|embryonic pattern specification|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			central_nervous_system(1)|large_intestine(4)|lung(3)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GATGGGCTCCCCTCTGAACCC	0.398000													7	22					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219300	67219300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67219300C>T	ENST00000312457.2	-	1	900	c.896G>A	c.(895-897)aGt>aAt	p.S299N		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	299						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GAGGTCGGCACTGGCCATGAG	0.657000													11	78					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563712	176563712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176563712G>A	ENST00000367662.3	+	3	2136	c.972G>A	c.(970-972)ggG>ggA	p.G324G	PAPPA2_ENST00000367661.3_Silent_p.G324G	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	324					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGGCCCTGGGGATCCGCTCAG	0.532000													10	68					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122114506	122114506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122114506G>A	ENST00000334010.7	-	12	2351	c.1930C>T	c.(1930-1932)Cat>Tat	p.H644Y	CADPS2_ENST00000449022.2_Missense_Mutation_p.H643Y|CADPS2_ENST00000313070.7_Missense_Mutation_p.H640Y|CADPS2_ENST00000412584.2_Missense_Mutation_p.H640Y	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	643					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						AGGAAGGCATGATCAAGCTTG	0.393000													25	46					0	0	1	0	0
ASAH2B	653308	broad.mit.edu	37	10	52502754	52502754	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52502754C>T	ENST00000374006.1	+	2	135	c.70C>T	c.(70-72)Cta>Tta	p.L24L	ASAH2B_ENST00000185907.9_5'UTR|ASAH2B_ENST00000483649.1_3'UTR|ASAH2B_ENST00000374007.1_5'UTR	NM_001079516.1	NP_001072984.1	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B	639					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(2)|lung(2)	4						AGAAACCTTGCTAAGGCTATT	0.483000													15	166					0	0	1	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140764587	140764587	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140764587C>T	ENST00000518325.1	+	1	2121	c.2121C>T	c.(2119-2121)ttC>ttT	p.F707F	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTAGCCTTCGTCCTCGTAC	0.627000													28	69					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55174728	55174728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55174728C>T	ENST00000414150.2	+	23	3987	c.3709C>T	c.(3709-3711)Cgt>Tgt	p.R1237C	MROH7_ENST00000454855.2_Missense_Mutation_p.R755C|MROH7_ENST00000421030.2_Missense_Mutation_p.R1237C|MROH7_ENST00000409996.1_Missense_Mutation_p.R805C					maestro heat-like repeat family member 7																		GACAGAAGATCGTCTGAATGA	0.517000													25	78					0	0	1	0	0
CCDC69	26112	broad.mit.edu	37	5	150578630	150578630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150578630C>T	ENST00000355417.2	-	4	421	c.247G>A	c.(247-249)Gag>Aag	p.E83K	CCDC69_ENST00000521308.1_5'UTR	NM_015621.2	NP_056436.2	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69	83										haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|stomach(1)	9		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCTCTAGCTCCCTTTCCTTC	0.557000													45	127					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32810233	32810233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32810233C>T	ENST00000380250.3	+	43	6230	c.5734C>T	c.(5734-5736)Ctc>Ttc	p.L1912F		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1912					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AATGGAAGCGCTCCTAACCTT	0.388000													12	50					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6484041	6484041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6484041G>A	ENST00000263125.5	-	16	1749	c.1650C>T	c.(1648-1650)atC>atT	p.I550I	PRKCQ_ENST00000397176.2_Intron|PRKCQ_ENST00000539722.1_Silent_p.I425I	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	550	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						GACCCAGCAAGATCTGCACAA	0.507000													11	45					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189455532	189455532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189455532C>T	ENST00000264731.3	+	2	155	c.66C>T	c.(64-66)ttC>ttT	p.F22F	TP63_ENST00000392460.3_Silent_p.F22F|TP63_ENST00000440651.2_Silent_p.F22F|TP63_ENST00000320472.5_Silent_p.F22F|TP63_ENST00000382063.4_Silent_p.F22F|TP63_ENST00000418709.2_Silent_p.F22F	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	22	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TTTTAAGTTTCGTAGAAACCC	0.348000										HNSCC(45;0.13)			27	96					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75888726	75888726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75888726C>T	ENST00000274364.6	+	9	1180	c.883C>T	c.(883-885)Caa>Taa	p.Q295*	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	295					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGCAGAAATCCAAGGCAATAT	0.358000													56	124					0	0	1	0	0
OGN	4969	broad.mit.edu	37	9	95148533	95148533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95148533C>T	ENST00000262551.4	-	6	1096	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K	CENPP_ENST00000375587.3_Intron|OGN_ENST00000375561.5_Missense_Mutation_p.E226K	NM_033014.2	NP_148935.1	P20774	MIME_HUMAN	osteoglycin	226						extracellular space|proteinaceous extracellular matrix	growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	13						GGCACGGATTCCAGGGCATTA	0.378000													25	75					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234197	21234197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21234197G>A	ENST00000233242.1	-	26	5670	c.5543C>T	c.(5542-5544)tCa>tTa	p.S1848L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1848					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATAGCTTGCTGATAAGGCAGC	0.478000													18	164					0	0	1	0	0
KCNN2	3781	broad.mit.edu	37	5	113698904	113698904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:113698904C>T	ENST00000512097.3	+	2	1450	c.432C>T	c.(430-432)ttC>ttT	p.F144F	KCNN2_ENST00000264773.3_Silent_p.F144F|KCNN2_ENST00000507750.1_3'UTR			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	144						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TCGGCATGTTCGGCATCGTGG	0.612000													9	37					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3547939	3547939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3547939C>T	ENST00000355415.2	-	4	913	c.744G>A	c.(742-744)gaG>gaA	p.E248E	MFSD12_ENST00000398558.4_Silent_p.E248E|MFSD12_ENST00000389395.3_Silent_p.E248E|MFSD12_ENST00000591878.1_5'UTR|AC005786.7_ENST00000589360.1_RNA	NM_174983.3	NP_778148.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	248					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						CGCCTGGCTCCTCCGCATGCG	0.697000													7	17					0	0	1	0	0
CCM2L	140706	broad.mit.edu	37	20	30617636	30617636	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30617636T>A	ENST00000300415.8	+	9	1410	c.1397T>A	c.(1396-1398)cTc>cAc	p.L466H	RP1-310O13.7_ENST00000449519.1_RNA|CCM2L_ENST00000262659.8_3'UTR					cerebral cavernous malformation 2-like																		AAGTTCCTCCTCCTTGGTGAG	0.612000													8	49					0	0	1	0	0
PRKAR2B	5577	broad.mit.edu	37	7	106710741	106710741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:106710741G>A	ENST00000265717.4	+	2	582	c.323G>A	c.(322-324)cGa>cAa	p.R108Q	PRKAR2B_ENST00000393613.2_3'UTR	NM_002736.2	NP_002727.2	P31323	KAP3_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, beta	108	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	14						GTAATAAACCGATTCACAAGG	0.313000													26	74					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222493	140222493	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140222493G>A	ENST00000531613.1	+	1	1587	c.1587G>A	c.(1585-1587)gaG>gaA	p.E529E	PCDHA8_ENST00000378123.3_Silent_p.E529E|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGCTAGAGCTGCTGCAGT	0.677000													69	39					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54577320	54577320	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54577320G>A	ENST00000251636.5	-	12	2137	c.1989C>T	c.(1987-1989)atC>atT	p.I663I	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	663	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				ATTCCATCCGGATCTGATATC	0.393000													23	98					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880394	74880394	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74880394T>C	ENST00000289575.5	+	5	1020	c.625T>C	c.(625-627)Ttt>Ctt	p.F209L	SLCO2B1_ENST00000428359.2_Missense_Mutation_p.F187L|SLCO2B1_ENST00000454962.2_Intron|SLCO2B1_ENST00000341411.4_Intron|SLCO2B1_ENST00000526660.1_Intron|SLCO2B1_ENST00000531756.1_Intron|SLCO2B1_ENST00000532236.1_Missense_Mutation_p.F93L|SLCO2B1_ENST00000525650.1_Missense_Mutation_p.F65L	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	209					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	CATTCAGCCCTTTGGCATCTC	0.597000													22	78					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656113	40656113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:40656113C>T	ENST00000406785.1	-	2	1497	c.1308G>A	c.(1306-1308)ttG>ttA	p.L436L	SLC8A1_ENST00000408028.2_Silent_p.L436L|SLC8A1_ENST00000542756.1_Silent_p.L436L|SLC8A1_ENST00000542024.1_Silent_p.L436L|SLC8A1_ENST00000403092.1_Silent_p.L436L|SLC8A1_ENST00000405901.3_Silent_p.L436L|SLC8A1_ENST00000405269.1_Silent_p.L436L|SLC8A1_ENST00000332839.4_Silent_p.L436L|SLC8A1_ENST00000402441.1_Silent_p.L436L|SLC8A1_ENST00000406391.2_Silent_p.L436L			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	436	Calx-beta 1.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CAGTGTTAGTCAAATCACCAC	0.443000													26	79					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145006619	145006619	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145006619G>A	ENST00000322810.4	-	16	2506	c.2337C>T	c.(2335-2337)ttC>ttT	p.F779F	PLEC_ENST00000354589.3_Silent_p.F642F|PLEC_ENST00000357649.2_Silent_p.F646F|PLEC_ENST00000527096.1_Silent_p.F665F|PLEC_ENST00000356346.3_Silent_p.F628F|PLEC_ENST00000354958.2_Silent_p.F620F|PLEC_ENST00000345136.3_Silent_p.F642F|PLEC_ENST00000436759.2_Silent_p.F669F|PLEC_ENST00000398774.2_Silent_p.F610F	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	779	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGCTCCAGTCGAAGCCCACCT	0.632000													24	64					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	394645	394645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:394645G>A	ENST00000280886.6	-	26	3254	c.3167C>T	c.(3166-3168)aCc>aTc	p.T1056I		NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	1056						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGACGGACGGTTATTGGCAC	0.547000													59	163					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19498517	19498517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19498517C>T	ENST00000396229.2	+	17	3191	c.2442C>T	c.(2440-2442)atC>atT	p.I814I	TMC5_ENST00000542583.2_Silent_p.I814I|TMC5_ENST00000564959.1_Silent_p.I497I|TMC5_ENST00000561503.1_Silent_p.I455I|CTA-363E6.6_ENST00000561762.1_RNA|TMC5_ENST00000219821.5_Silent_p.I568I|TMC5_ENST00000541464.1_Silent_p.I762I|TMC5_ENST00000381414.4_Silent_p.I814I	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	814						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CTCTTCAGATCAGCCTGATGA	0.587000													15	49					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39247056	39247056	+	Silent	SNP	C	C	T	rs142566948		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:39247056C>T	ENST00000518318.2	+	4	390	c.348C>T	c.(346-348)gcC>gcT	p.A116A	POU6F2_ENST00000559001.1_Silent_p.A108A|POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_Silent_p.A116A			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	116					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						GCCCCCCAGCCCTCAACCAGC	0.577000													58	157					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55339669	55339669	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55339669G>A	ENST00000314634.3	+	1	66	c.66G>A	c.(64-66)aaG>aaA	p.K22K		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				CTTTTTGGAAGAAAATAGTGT	0.398000													18	139					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501772	90501772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90501772C>T	ENST00000325643.5	+	4	2436	c.2370C>T	c.(2368-2370)ctC>ctT	p.L790L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GCTCCTGGCTCATGGCCAAAT	0.577000													6	65					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149227972	149227972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:149227972C>T	ENST00000407073.1	+	9	3457	c.2460C>T	c.(2458-2460)tcC>tcT	p.S820S	MBD5_ENST00000404807.1_Silent_p.S820S	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	820						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CAACGTCCTCCACTCCAGTGA	0.428000													27	90					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28149675	28149675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28149675G>A	ENST00000305242.5	-	19	2992	c.2900C>T	c.(2899-2901)cCa>cTa	p.P967L	ARMC4_ENST00000537576.1_Missense_Mutation_p.P659L|ARMC4_ENST00000545014.1_Missense_Mutation_p.P492L	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	967							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						ACGCACTAGTGGAGCCACTGC	0.478000													27	66					0	0	1	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124229290	124229290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124229290C>T	ENST00000330342.3	+	12	1721	c.1473C>T	c.(1471-1473)tcC>tcT	p.S491S		NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	491					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		TGTACAGCTCCAGCCACCCAC	0.527000													22	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068061	9068061	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9068061C>T	ENST00000397910.4	-	3	19588	c.19385G>A	c.(19384-19386)tGg>tAg	p.W6462*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6464	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATGTGTCCCAGGTAAGGGT	0.483000													54	137					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94945194	94945194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94945194C>T	ENST00000357742.4	+	16	2031	c.2031C>T	c.(2029-2031)ttC>ttT	p.F677F	MCTP2_ENST00000451018.3_Silent_p.F677F|MCTP2_ENST00000331706.4_Silent_p.F265F|MCTP2_ENST00000557742.1_Silent_p.F265F	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	677					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CAATGCAGTTCCTTAAAAGCT	0.353000													21	121					0	0	1	0	0
COLEC12	81035	broad.mit.edu	37	18	346892	346892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:346892G>A	ENST00000400256.3	-	5	937	c.730C>T	c.(730-732)Ctg>Ttg	p.L244L		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	244					carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				ACCTGCTGCAGATTTTGAAAG	0.527000													28	85					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179666962	179666962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179666962C>T	ENST00000589042.1	-	3	422	c.198G>A	c.(196-198)acG>acA	p.T66T	TTN_ENST00000342992.6_Silent_p.T66T|TTN_ENST00000360870.5_Silent_p.T66T|TTN_ENST00000460472.2_Silent_p.T66T|TTN_ENST00000342175.6_Silent_p.T66T|TTN_ENST00000359218.5_Silent_p.T66T|TTN_ENST00000591111.1_Silent_p.T66T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	66	Ig-like 1.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGCGGGGATCGTCAGTTTAG	0.542000													31	84					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447371	226447371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:226447371C>T	ENST00000272907.6	+	4	1651	c.1238C>T	c.(1237-1239)tCg>tTg	p.S413L	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	413	Pro-rich.																CTCTCCTCGTCGCCCCCACCC	0.682000													5	15					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132527047	132527047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:132527047G>A	ENST00000331898.7	-	2	913	c.335C>T	c.(334-336)cCg>cTg	p.P112L	OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000541867.1_Missense_Mutation_p.P112L|OPCML_ENST00000524381.1_Missense_Mutation_p.P105L|OPCML_ENST00000374778.4_Missense_Mutation_p.P71L	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	112	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity	p.P112L(1)		endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GCAGGTGTACGGACCTTCGTC	0.502000													22	89					0	0	1	0	0
NRG4	145957	broad.mit.edu	37	15	76254290	76254290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:76254290G>A	ENST00000394907.3	-	4	311	c.130C>T	c.(130-132)Cgt>Tgt	p.R44C	NRG4_ENST00000535975.1_Missense_Mutation_p.R44C	NM_138573.3	NP_612640.1	Q8WWG1	NRG4_HUMAN	neuregulin 4	44	EGF-like.					extracellular region|integral to membrane|plasma membrane	growth factor activity			large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5						TCTTCACAACGAGCTCCTGTA	0.388000													73	85					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29642577	29642577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:29642577C>T	ENST00000373779.3	+	24	3556	c.3427C>T	c.(3427-3429)Cct>Tct	p.P1143S	PTPRU_ENST00000323874.8_Missense_Mutation_p.P1149S|PTPRU_ENST00000356870.3_Missense_Mutation_p.P1149S|PTPRU_ENST00000345512.3_Missense_Mutation_p.P1153S|PTPRU_ENST00000428026.2_Missense_Mutation_p.P1140S|PTPRU_ENST00000460170.2_Missense_Mutation_p.P1149S	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1153	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GACCACCATCCCTGTCAGTGA	0.557000													18	58					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43634857	43634857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43634857C>T	ENST00000360835.3	-	7	957	c.831G>A	c.(829-831)ggG>ggA	p.G277G	Z82214.2_ENST00000419643.1_RNA|SCUBE1_ENST00000290460.7_Silent_p.G307G	NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	277	EGF-like 5 (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				TGCATGTCTTCCCGTCCGGCT	0.637000													8	48					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159650951	159650951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159650951G>A	ENST00000297267.9	+	10	1485	c.1285G>A	c.(1285-1287)Gaa>Aaa	p.E429K	FNDC1_ENST00000340366.6_Intron	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	429	Fibronectin type-III 4.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCAGCCTGGGGAACGCTATCT	0.517000													108	137					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834543	101834543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101834543G>A	ENST00000506729.1	-	1	177	c.6C>T	c.(4-6)ttC>ttT	p.F2F	SLCO6A1_ENST00000379810.1_Silent_p.F2F|SLCO6A1_ENST00000513675.1_Silent_p.F2F|SLCO6A1_ENST00000389019.3_Silent_p.F2F|SLCO6A1_ENST00000379807.3_Silent_p.F2F			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	2						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CGACGCCTACGAACATGGCTC	0.711000													62	137					0	0	1	0	0
C1QB	713	broad.mit.edu	37	1	22987444	22987444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22987444C>T	ENST00000509305.1	+	3	667	c.321C>T	c.(319-321)ccC>ccT	p.P107P	C1QB_ENST00000314933.6_Silent_p.P109P			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	109	Collagen-like 2.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCCCAGGCCCCAAAGGTGAAT	0.632000													20	65					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110737331	110737331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110737331C>T	ENST00000331565.4	+	9	1915	c.1430C>T	c.(1429-1431)aCc>aTc	p.T477I	SLC6A17_ENST00000465159.1_3'UTR	NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	477					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		ATGATCGGGACCATGGCAGGC	0.602000													14	58					0	0	1	0	0
PRSS3	5646	broad.mit.edu	37	9	33796705	33796705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33796705C>T	ENST00000361005.5	+	2	276	c.276C>T	c.(274-276)ctC>ctT	p.L92L	PRSS3_ENST00000379405.3_Silent_p.L35L|PRSS3_ENST00000342836.4_Silent_p.L49L|RP11-133O22.6_ENST00000454429.2_RNA|PRSS3_ENST00000429677.3_Silent_p.L28L	NM_007343.3	NP_031369.2	P35030	TRY3_HUMAN	protease, serine, 3	92	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity			large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	13			LUSC - Lung squamous cell carcinoma(29;0.0176)			AGAATTCTCTCCCCTACCAGG	0.532000													10	176					0	0	1	0	0
LRRC57	255252	broad.mit.edu	37	15	42837368	42837368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42837368C>T	ENST00000323443.2	-	4	952	c.585G>A	c.(583-585)caG>caA	p.Q195Q	LRRC57_ENST00000397130.3_Silent_p.Q195Q|LRRC57_ENST00000563454.1_Silent_p.Q195Q			Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	195										breast(1)|kidney(1)|lung(5)|prostate(1)	8		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		TGAGGATGCTCTGGGGAAGCA	0.423000													36	83					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38753715	38753715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38753715G>A	ENST00000449082.2	-	22	4025	c.4026C>T	c.(4024-4026)ttC>ttT	p.F1342F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1342					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CATTGACCCAGAAGAAGCTGC	0.428000													44	109					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18062264	18062264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18062264G>A	ENST00000205890.5	+	53	9447	c.9109G>A	c.(9109-9111)Gag>Aag	p.E3037K	MYO15A_ENST00000418233.3_Missense_Mutation_p.E301K	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	3037	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					GAAATCCAAGGAGCCTCGGGA	0.562000													13	35					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141051219	141051219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141051219C>T	ENST00000239440.4	-	12	1837	c.1772G>A	c.(1771-1773)gGa>gAa	p.G591E	ARAP3_ENST00000508305.1_Missense_Mutation_p.G513E|ARAP3_ENST00000513878.1_Missense_Mutation_p.G253E	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	591	Arf-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						GATGAACTCTCCCCGGGGGCC	0.592000													14	48					0	0	1	0	0
SLC35C1	55343	broad.mit.edu	37	11	45832766	45832766	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:45832766G>A	ENST00000314134.3	+	2	2371	c.975G>A	c.(973-975)acG>acA	p.T325T	SLC35C1_ENST00000442528.2_Silent_p.T312T|SLC35C1_ENST00000456334.1_Silent_p.T312T	NM_018389.4	NP_060859.4	Q96A29	FUCT1_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C1	325						Golgi membrane|integral to membrane	GDP-fucose transmembrane transporter activity			endometrium(3)|kidney(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				GBM - Glioblastoma multiforme(35;0.227)		TCTGGTGGACGAGCAACATGA	0.632000													22	16					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55196641	55196641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55196641G>A	ENST00000340465.2	+	2	237	c.151G>A	c.(151-153)Gat>Aat	p.D51N		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	51						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TGCCTGCAATGATTCAGGTAA	0.318000													11	31					0	0	1	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086784	46086784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46086784G>A	ENST00000360770.3	-	1	60	c.20C>T	c.(19-21)tCc>tTc	p.S7F	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	7						keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						GCAGCCCGAGGAGCAGCTGGT	0.667000													9	16					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21069001	21069001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21069001C>T	ENST00000381545.3	+	16	2148	c.1929C>T	c.(1927-1929)ttC>ttT	p.F643F	SLCO1B3_ENST00000261196.2_Silent_p.F643F|LST3_ENST00000540229.1_Intron|SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	643					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATATTGTTTTCATTTTTGCTA	0.303000													15	45					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158609381	158609381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158609381C>T	ENST00000368148.3	-	35	5151	c.4971G>A	c.(4969-4971)ttG>ttA	p.L1657L	SPTA1_ENST00000368147.3_Silent_p.L1657L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1657					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CCTCTCGAGCCAACATCTCTC	0.483000													20	120					0	0	1	0	0
SALL4	57167	broad.mit.edu	37	20	50401220	50401220	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50401220G>A	ENST00000217086.4	-	4	2857	c.2746C>T	c.(2746-2748)Cac>Tac	p.H916Y	SALL4_ENST00000371539.3_Missense_Mutation_p.H139Y|SALL4_ENST00000395997.3_Missense_Mutation_p.H479Y	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	916					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTCATGTAGTGAACCTATGGG	0.468000													19	64					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768403	117768403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117768403C>T	ENST00000317775.6	-	2	1157	c.472G>A	c.(472-474)Ggg>Agg	p.G158R	NOS1_ENST00000344089.3_Missense_Mutation_p.G158R|NOS1_ENST00000338101.4_Missense_Mutation_p.G158R	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	158	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGCTGAGGCCCATTCCCGGGA	0.701000													20	93					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205042351	205042351	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205042351C>T	ENST00000331830.4	+	22	3284	c.3000C>T	c.(2998-3000)atC>atT	p.I1000I		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	1000	Fibronectin type-III 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAGTCCACATCGTGAGGAATG	0.567000													22	64					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58701016	58701016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58701016C>T	ENST00000305921.3	+	2	839	c.607C>T	c.(607-609)Ccg>Tcg	p.P203S		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	203	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			TCAGGATGACCCGAAGGATGA	0.507000													49	92					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74364604	74364604	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74364604C>T	ENST00000290438.3	-	14	1588	c.1548G>A	c.(1546-1548)cgG>cgA	p.R516R		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	516										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						TTGGCGTGGGCCGAGGCGCCT	0.632000													17	175					0	0	1	0	0
WDR60	55112	broad.mit.edu	37	7	158663943	158663943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:158663943C>T	ENST00000407559.3	+	3	338	c.180C>T	c.(178-180)ccC>ccT	p.P60P		NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	60										NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		GCAGGGATCCCGACCAGGATG	0.567000													11	13					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48261760	48261760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48261760G>A	ENST00000394747.1	-	3	701	c.352C>T	c.(352-354)Cct>Tct	p.P118S	ABCC11_ENST00000537808.1_Missense_Mutation_p.P118S|ABCC11_ENST00000353782.5_Missense_Mutation_p.P118S|ABCC11_ENST00000394748.1_Missense_Mutation_p.P118S|ABCC11_ENST00000356608.2_Missense_Mutation_p.P118S	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	118						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GACAGTGGAGGGATGGTGTTC	0.522000													44	128					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125083791	125083791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125083791G>A	ENST00000522917.1	+	31	4217	c.4011G>A	c.(4009-4011)gaG>gaA	p.E1337E	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Silent_p.E1337E	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1337						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTAGCTCTGAGGACAGCGGGC	0.512000													16	39					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52565264	52565264	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52565264T>G	ENST00000394815.2	-	9	1374	c.1277A>C	c.(1276-1278)aAg>aCg	p.K426T	KRT80_ENST00000313234.5_3'UTR	NM_182507.2	NP_872313.2	Q6KB66	K2C80_HUMAN	keratin 80	426	Tail.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		GCTGCCCTTCTTCTTTCGGGA	0.577000													21	52					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15881966	15881966	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15881966G>A	ENST00000587443.2	-	0	931					NR_033864.1																						CGTCATGGGAGAGGTAATACA	0.557000													30	72					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31284752	31284752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31284752G>A	ENST00000544665.3	+	8	842	c.771G>A	c.(769-771)acG>acA	p.T257T	ITGAM_ENST00000287497.8_Silent_p.T257T	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	257	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TTGTCATCACGGATGGAGAAA	0.498000													36	54					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86965435	86965435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86965435G>A	ENST00000234701.3	+	15	2803	c.2452G>A	c.(2452-2454)Gaa>Aaa	p.E818K	CLCA1_ENST00000394711.1_Missense_Mutation_p.E818K			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	818					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CATCCCAAAGGAAGCCAACTC	0.363000													37	160					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487739	248487739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248487739G>A	ENST00000317965.2	-	1	160	c.132C>T	c.(130-132)atC>atT	p.I44I		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGAGAACCATGATGGAGTTTC	0.532000													113	324					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84270886	84270886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84270886C>T	ENST00000568181.1	-	2	326	c.206G>A	c.(205-207)aGg>aAg	p.R69K	KCNG4_ENST00000308251.4_Missense_Mutation_p.R69K			Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	69						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GAGGAGATACCTCCTGCCCCC	0.622000													13	80					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	39966859	39966859	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39966859C>T	ENST00000336649.4	+	1	102	c.102C>T	c.(100-102)tcC>tcT	p.S34S	CACNA1I_ENST00000404898.1_Silent_p.S34S|CACNA1I_ENST00000402142.3_Silent_p.S34S|CACNA1I_ENST00000401624.1_Silent_p.S34S|CACNA1I_ENST00000400164.3_Silent_p.S34S|CACNA1I_ENST00000407673.1_Silent_p.S34S			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	34					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CCCCATCCTCCCCGCCAGGCC	0.687000													11	34					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102250605	102250605	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102250605G>A	ENST00000370345.3	-	20	2605	c.2508C>T	c.(2506-2508)acC>acT	p.T836T		NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	836	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		ATGACTGAGGGGTGAAAACCC	0.488000													10	54					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271387	22271387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22271387C>T	ENST00000594947.1	+	4	979	c.835C>T	c.(835-837)Cat>Tat	p.H279Y		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAGAGAATTCATAATAGAGA	0.378000													14	38					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42821976	42821976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42821976G>A	ENST00000598766.1	+	12	1088	c.1088G>A	c.(1087-1089)cGa>cAa	p.R363Q	TMEM145_ENST00000301204.3_Missense_Mutation_p.R339Q			Q8NBT3	TM145_HUMAN	transmembrane protein 145	339						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				GTCTCACTGCGACACTTTCCT	0.582000													8	122					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794845	126794845	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126794845C>T	ENST00000373615.4	+	5	1819	c.1080C>T	c.(1078-1080)ccC>ccT	p.P360P		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	360						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						CGCTCAGCCCCTCCAGCACGC	0.657000													14	37					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14752664	14752664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14752664G>A	ENST00000358984.4	+	2	501	c.321G>A	c.(319-321)agG>agA	p.R107R	ANKRD30B_ENST00000447268.2_Silent_p.R107R|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	107										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						GCGAAGGGAGGACACCTCTGA	0.413000													3	8					0	0	1	0	0
UPB1	51733	broad.mit.edu	37	22	24898487	24898487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24898487C>T	ENST00000382760.2	+	4	709	c.547C>T	c.(547-549)Cct>Tct	p.P183S	UPB1_ENST00000326010.5_Intron|UPB1_ENST00000413389.2_Intron			Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	0	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					cagctggtctcctgtgccctc	0.527000													42	93					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	67726390	67726390	+	Missense_Mutation	SNP	C	C	T	rs145119798	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:67726390C>T	ENST00000433211.1	-	17	2554	c.2380G>A	c.(2380-2382)Gga>Aga	p.G794R	CTNNA3_ENST00000373735.1_Missense_Mutation_p.G133R|CTNNA3_ENST00000373744.4_Missense_Mutation_p.G794R	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	794					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						ATGAGCTCTCCTCCCAGGTTC	0.448000													37	94					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800953	185800953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185800953C>T	ENST00000302277.6	+	4	1424	c.830C>T	c.(829-831)tCt>tTt	p.S277F		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	277						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAAACTAACTCTTTTCATCCA	0.368000													20	93					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74714335	74714335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74714335G>A	ENST00000373032.3	-	1	201	c.109C>T	c.(109-111)Cgg>Tgg	p.R37W		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	37					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					CGGAGGTGCCGAAGGCCCCAG	0.572000													64	157					0	0	1	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874201	31874201	+	Missense_Mutation	SNP	C	C	T	rs73186218	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31874201C>T	ENST00000334151.2	-	1	234	c.208G>A	c.(208-210)Gga>Aga	p.G70R		NM_181611.1	NP_853642.1	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	70						intermediate filament	protein binding			endometrium(1)|large_intestine(5)|lung(4)|pancreas(1)|prostate(1)	12						CAATAAAATCCAGAGAATCCA	0.502000													41	124					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159922231	159922231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159922231C>T	ENST00000368093.3	-	3	601	c.485G>A	c.(484-486)gGc>gAc	p.G162D	SLAMF9_ENST00000368092.3_Intron|SLAMF9_ENST00000466773.1_5'UTR	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	162	Ig-like C2-type.					integral to membrane		p.G162D(1)		breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATATCCATGCCTGCCTTCTC	0.577000													65	98					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915014	119915014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:119915014G>A	ENST00000331113.4	+	1	1293	c.328G>A	c.(328-330)Gag>Aag	p.E110K		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	110					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TCCTCGCCACGAGTGCATCTC	0.527000													53	199					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71576875	71576875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71576875C>T	ENST00000409544.1	+	2	1421	c.791C>T	c.(790-792)cCt>cTt	p.P264L	ZNF638_ENST00000264447.4_Missense_Mutation_p.P264L|ZNF638_ENST00000377802.2_Missense_Mutation_p.P264L|ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000355812.3_Missense_Mutation_p.P264L	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	264					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TCTATGTTTCCTGTTGAAGAC	0.428000													58	147					0	0	1	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30951447	30951447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30951447G>A	ENST00000402321.1	-	3	1082	c.765C>T	c.(763-765)ttC>ttT	p.F255F	GAL3ST1_ENST00000338911.5_Silent_p.F255F|GAL3ST1_ENST00000401975.1_Silent_p.F255F|GAL3ST1_ENST00000406955.1_Silent_p.F255F|GAL3ST1_ENST00000443111.2_Silent_p.F255F|GAL3ST1_ENST00000406361.1_Silent_p.F255F|GAL3ST1_ENST00000402369.1_Silent_p.F255F			Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	255					protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity	p.F255F(1)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21						GCGACTCGTCGAAGTACTCTT	0.647000													30	112					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543009	28543009	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28543009G>A	ENST00000452236.2	-	3	2090	c.1473C>T	c.(1471-1473)aaC>aaT	p.N491N		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	491	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						AGTGTGATGAGTTGTTAGTTT	0.433000													48	104					0	0	1	0	0
FRMD1	79981	broad.mit.edu	37	6	168479715	168479715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:168479715G>A	ENST00000283309.6	-	1	124	c.60C>T	c.(58-60)ttC>ttT	p.F20F		NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	20						cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CTGAAGGAGGGAACGTGTCAG	0.662000													15	37					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205899140	205899140	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205899140G>A	ENST00000367135.3	-	6	710	c.597C>T	c.(595-597)ctC>ctT	p.L199L	SLC26A9_ENST00000367134.2_Silent_p.L199L|SLC26A9_ENST00000340781.4_Silent_p.L199L	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	199						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			AGGACTCGGAGAGGTAGATGG	0.567000													12	37					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62855787	62855787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62855787G>A	ENST00000584306.1	-	11	5007	c.4477C>T	c.(4477-4479)Ctc>Ttc	p.L1493F	LRRC37A3_ENST00000400877.3_Missense_Mutation_p.L531F|LRRC37A3_ENST00000334962.5_Missense_Mutation_p.L470F|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.L1493F|LRRC37A3_ENST00000339474.5_Missense_Mutation_p.L611F	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1493						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TGAGCAATGAGCCTTCTCACA	0.517000													103	366					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110489988	110489988	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:110489988C>T	ENST00000324068.1	-	13	1911		c.e13-1		CAPN6_ENST00000541758.1_Splice_Site	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6						microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						TGTTCCAGACCTGGAAAGACA	0.493000													25	11					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73486830	73486830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73486830C>T	ENST00000314256.7	+	11	1513	c.1119C>T	c.(1117-1119)gtC>gtT	p.V373V	KIAA0195_ENST00000579208.1_Silent_p.V24V|KIAA0195_ENST00000375248.5_Silent_p.V383V	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	373					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGGAGGCTGTCTCCTCTCAGG	0.557000													15	37					0	0	1	0	0
CFHR2	3080	broad.mit.edu	37	1	196928210	196928210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196928210G>A	ENST00000367415.4	+	5	927	c.813G>A	c.(811-813)taG>taA	p.*271*	CFHR2_ENST00000367421.3_Silent_p.*271*	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	0						extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						AAGAAAAATAGAATCAATGGC	0.284000													14	59					0	0	1	0	0
OR13C9	286362	broad.mit.edu	37	9	107379817	107379817	+	Silent	SNP	G	G	A	rs74950199		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107379817G>A	ENST00000259362.1	-	1	668	c.669C>T	c.(667-669)tcC>tcT	p.S223S		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						TGAGGATGCTGGAAATGATTA	0.443000													37	66					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72176258	72176258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:72176258G>A	ENST00000555818.1	+	15	4496	c.4148G>A	c.(4147-4149)gGc>gAc	p.G1383D	SIPA1L1_ENST00000381232.3_Missense_Mutation_p.G1362D|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.G837D|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.G1362D|SIPA1L1_ENST00000554874.1_3'UTR	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1383	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAGAGCCACGGCCTGGACCGG	0.562000													20	42					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107748257	107748257	+	Missense_Mutation	SNP	C	C	T	rs147178647		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107748257C>T	ENST00000388781.3	-	6	493	c.410G>A	c.(409-411)cGg>cAg	p.R137Q	LAMB4_ENST00000205386.4_Missense_Mutation_p.R137Q|LAMB4_ENST00000414450.2_Missense_Mutation_p.R137Q|LAMB4_ENST00000388780.3_Missense_Mutation_p.R137Q	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	137	Laminin N-terminal.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TGCAGCAGGCCGAAAAGTCTA	0.348000													21	40					0	0	1	0	0
ING3	54556	broad.mit.edu	37	7	120609222	120609222	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120609222C>T	ENST00000315870.5	+	9	1020	c.872C>T	c.(871-873)tCa>tTa	p.S291L	ING3_ENST00000431467.1_Missense_Mutation_p.S276L	NM_019071.2	NP_061944.2	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3	291					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			NS(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	12	all_neural(327;0.117)					AATGCCAGTTCATCAGCAGCC	0.418000													24	69					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10089688	10089688	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10089688C>T	ENST00000287647.3	+	16	1459	c.1366C>T	c.(1366-1368)Ctc>Ttc	p.L456F	FANCD2_ENST00000383806.1_Missense_Mutation_p.L456F|FANCD2_ENST00000383807.1_Missense_Mutation_p.L456F|FANCD2_ENST00000419585.1_Missense_Mutation_p.L456F	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	456			L -> R (in dbSNP:rs35782247).		DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ATTTGGCAGTCTCCTATACAA	0.393000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				14	225					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24442218	24442218	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:24442218C>T	ENST00000383168.4	-	2	503	c.375G>A	c.(373-375)ggG>ggA	p.G125G	AQP4_ENST00000581374.1_Silent_p.G103G|AQP4_ENST00000440832.3_Silent_p.G103G|AQP4-AS1_ENST00000582605.1_RNA|AQP4-AS1_ENST00000579964.1_RNA	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	125					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					CAATGATGGCCCCCAGGCACT	0.557000													28	67					0	0	1	0	0
CINP	51550	broad.mit.edu	37	14	102816294	102816294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102816294C>T	ENST00000216756.6	-	4	438	c.398G>A	c.(397-399)cGa>cAa	p.R133Q	CINP_ENST00000541568.2_Intron|CINP_ENST00000536961.2_Missense_Mutation_p.R148Q	NM_032630.2	NP_116019.1	Q9BW66	CINP_HUMAN	cyclin-dependent kinase 2 interacting protein	133					cell cycle|cell division|DNA repair|DNA replication	nucleus	protein binding			large_intestine(2)|lung(2)	4						CAGAGGGGGTCGTTTACTCTC	0.413000													20	45					0	0	1	0	0
DEPTOR	64798	broad.mit.edu	37	8	121013894	121013894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121013894C>T	ENST00000286234.5	+	5	865	c.735C>T	c.(733-735)ccC>ccT	p.P245P	DEPTOR_ENST00000518057.1_3'UTR|DEPTOR_ENST00000523492.1_Silent_p.P144P	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	245	Ser-rich.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						ATGACAGTCCCTTCTGCCTGA	0.493000													15	60					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197032181	197032181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197032181G>A	ENST00000367412.1	-	2	114	c.71C>T	c.(70-72)cCc>cTc	p.P24L		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	24	Sushi 1.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						AAAACCACAGGGTTTCTCTGA	0.294000													62	163					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74163761	74163761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74163761G>A	ENST00000269391.6	-	4	546	c.414C>T	c.(412-414)gcC>gcT	p.A138A	RNF157_ENST00000319945.6_Silent_p.A138A	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	138							zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			ACTCTTCCGTGGCCTGGTAAT	0.498000													27	108					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36706717	36706717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:36706717G>A	ENST00000280527.2	+	7	1619	c.1252G>A	c.(1252-1254)Gaa>Aaa	p.E418K		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	418	VWFC 2.				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CCGGTGGCGGGAAGACGACTG	0.552000													7	118					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36149243	36149243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36149243G>A	ENST00000303965.4	-	18	3615	c.3126C>T	c.(3124-3126)tcC>tcT	p.S1042S		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1042	PH 4.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AATGCAAGCTGGATTTGTCCA	0.408000													19	64					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18347479	18347479	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18347479G>A	ENST00000429452.1	-	23	3515	c.3163C>T	c.(3163-3165)Ctg>Ttg	p.L1055L	MICAL3_ENST00000441493.2_Intron|MICAL3_ENST00000444520.1_Intron|MICAL3_ENST00000585038.1_Silent_p.L1055L|MICAL3_ENST00000207726.7_Intron|MICAL3_ENST00000400561.2_Intron|MICAL3_ENST00000383094.3_Intron|MICAL3_ENST00000414725.2_Intron	NM_001136004.1	NP_001129476.1	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	0	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		ACCTCCGACAGGCCATAGAGA	0.587000													7	26					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678498	88678498	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88678498C>T	ENST00000394480.1	-	10	1359	c.1038G>A	c.(1036-1038)aaG>aaA	p.K346K	NTRK3_ENST00000558676.1_Silent_p.K346K|NTRK3_ENST00000357724.2_Silent_p.K346K|NTRK3_ENST00000317501.3_Silent_p.K346K|NTRK3_ENST00000355254.2_Silent_p.K346K|NTRK3_ENST00000542733.2_Silent_p.K248K|NTRK3_ENST00000540489.2_Silent_p.K346K|NTRK3_ENST00000360948.2_Silent_p.K346K|NTRK3_ENST00000557856.1_Silent_p.K346K	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	346	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CATGGATGATCTTGGACTCCC	0.567000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			10	140					0	0	1	0	0
LCE1A	353131	broad.mit.edu	37	1	152800190	152800190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152800190G>A	ENST00000335123.2	+	1	242	c.242G>A	c.(241-243)aGa>aAa	p.R81K		NM_178348.2	NP_848125.1	Q5T7P2	LCE1A_HUMAN	late cornified envelope 1A	81	Cys-rich.				keratinization					endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	8	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACCGTCACAGACTCCAGAGC	0.697000													19	42					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23237062	23237062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23237062C>T	ENST00000400191.3	+	14	2708	c.2690C>T	c.(2689-2691)tCc>tTc	p.S897F	EPHB2_ENST00000374627.1_Missense_Mutation_p.S892F|EPHB2_ENST00000374630.3_Missense_Mutation_p.S897F|EPHB2_ENST00000374632.3_Missense_Mutation_p.S898F	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	897					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GCGCCCCTCTCCTCTGGGTAA	0.617000													10	30					0	0	1	0	0
MAX	4149	broad.mit.edu	37	14	65550981	65550981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65550981G>A	ENST00000246163.2	-	4	377	c.208C>T	c.(208-210)Ctt>Ttt	p.L70F	MAX_ENST00000555667.1_Intron|MAX_ENST00000341653.2_Intron|MAX_ENST00000358402.4_Intron|MAX_ENST00000284165.6_Intron|MAX_ENST00000555419.1_Intron|MAX_ENST00000358664.4_Intron|MAX_ENST00000557746.1_Intron|MAX_ENST00000557277.1_Intron|MAX_ENST00000556979.1_Intron|MAX_ENST00000555932.1_Intron|MAX_ENST00000556443.1_Intron|RP11-840I19.3_ENST00000556127.1_RNA	NM_145114.1	NP_660089.1	P61244	MAX_HUMAN	MYC associated factor X	0	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		TGACgatgaaggacaggagta	0.313000													46	71					0	0	1	0	0
ADNP	23394	broad.mit.edu	37	20	49511034	49511034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49511034G>A	ENST00000396029.3	-	5	784	c.217C>T	c.(217-219)Cct>Tct	p.P73S	ADNP_ENST00000396032.3_Missense_Mutation_p.P73S|ADNP_ENST00000349014.3_Missense_Mutation_p.P73S|ADNP_ENST00000371602.4_Missense_Mutation_p.P73S	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	73						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						CAGCAGAAAGGTTTTGTCCGA	0.393000													22	70					0	0	1	0	0
PDLIM3	27295	broad.mit.edu	37	4	186429496	186429496	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186429496G>A	ENST00000284770.5	-	5	692	c.619C>T	c.(619-621)Cag>Tag	p.Q207*	PDLIM3_ENST00000284771.6_Intron|PDLIM3_ENST00000284767.5_3'UTR	NM_014476.5	NP_055291.2	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	207						sarcomere	zinc ion binding			breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		ACCTGACCCTGGAGTGTTTCC	0.418000													40	96					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117235007	117235007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117235007G>A	ENST00000003084.6	+	15	2646	c.2514G>A	c.(2512-2514)gaG>gaA	p.E838E	CFTR_ENST00000454343.1_Silent_p.E777E	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	838					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ATGATATGGAGAGCATACCAG	0.333000									Cystic Fibrosis				9	46					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69409764	69409764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69409764C>T	ENST00000303714.4	+	16	1647	c.1325C>T	c.(1324-1326)tCc>tTc	p.S442F		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	442					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CGGCCTTCTTCCCCCCGGAAG	0.423000									Familial Infantile Hemangioma				27	83					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173556856	173556856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173556856G>A	ENST00000367714.3	-	5	893	c.471C>T	c.(469-471)atC>atT	p.I157I	SLC9C2_ENST00000536496.1_Silent_p.I55I|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	157					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										TGCCAAGGGTGATGCTAAAGA	0.323000													19	81					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48741088	48741088	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48741088G>A	ENST00000316623.5	-	46	6003	c.5548C>T	c.(5548-5550)Cgt>Tgt	p.R1850C		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1850	EGF-like 31; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CATTCATTACGATCTGTAAAT	0.348000													17	36					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47041551	47041551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47041551C>T	ENST00000450053.3	+	27	4141	c.3962C>T	c.(3961-3963)cCc>cTc	p.P1321L	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Intron	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1321	Pro-rich.						binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CCCAAGCCACCCACTGAGTCA	0.637000													20	62					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186389428	186389428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186389428C>T	ENST00000232003.4	+	4	488	c.408C>T	c.(406-408)gcC>gcT	p.A136A		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	136	Cystatin 1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CAGCACTGGCCAATACCAAAG	0.433000													40	70					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103908594	103908594	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103908594C>T	ENST00000278070.2	+	12	4677	c.4638C>T	c.(4636-4638)ttC>ttT	p.F1546F	PPRC1_ENST00000489648.1_3'UTR|PPRC1_ENST00000370012.1_Silent_p.F513F|PPRC1_ENST00000413464.2_Silent_p.F1282F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1546	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GGGTGGTCTTCATTGGAAAGA	0.483000													21	40					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24509770	24509770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:24509770G>A	ENST00000264463.4	-	7	1668	c.1161C>T	c.(1159-1161)tcC>tcT	p.S387S		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	387	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ACAGATAGGAGGACCTACTAA	0.393000										HNSCC(23;0.051)			27	53					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29754972	29754972	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29754972G>A	ENST00000389048.3	-	4	1869	c.963C>T	c.(961-963)ctC>ctT	p.L321L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	321	MAM 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGTTGAGAAGGAGAAAGGAGC	0.537000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				13	36					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980903	40980903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40980903G>A	ENST00000373198.3	-	10	1818	c.1583C>T	c.(1582-1584)tCg>tTg	p.S528L	PTPRT_ENST00000373193.3_Missense_Mutation_p.S528L|PTPRT_ENST00000373184.1_Missense_Mutation_p.S528L|PTPRT_ENST00000373201.1_Missense_Mutation_p.S528L|PTPRT_ENST00000373190.1_Missense_Mutation_p.S528L|PTPRT_ENST00000373187.1_Missense_Mutation_p.S528L|PTPRT_ENST00000356100.2_Missense_Mutation_p.S528L	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	528	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGGTCCAGCGAGCCGACAGC	0.532000													34	56					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322829	55322829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55322829G>A	ENST00000314644.2	+	1	1047	c.1047G>A	c.(1045-1047)caG>caA	p.Q349Q		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						AAGTAAAACAGGCCATGAGGA	0.328000										HNSCC(20;0.049)			33	76					0	0	1	0	0
IGLV9-49	28773	broad.mit.edu	37	22	22697996	22697996	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22697996G>A	ENST00000427632.2	+	0	321																											GGCCTGAATCGGTACCTGACC	0.567000											OREG0026357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	18					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540618	40540618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40540618G>A	ENST00000434248.1	-	5	2213	c.2148C>T	c.(2146-2148)taC>taT	p.Y716Y	ZNF780B_ENST00000221355.6_Silent_p.Y568Y	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	716					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGAATTCGGTAATGTTCAG	0.408000													27	74					0	0	1	0	0
DIRC2	84925	broad.mit.edu	37	3	122525735	122525735	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122525735C>T	ENST00000261038.5	+	2	773	c.375C>T	c.(373-375)ttC>ttT	p.F125F		NM_032839.2	NP_116228.1	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	125					transport	integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|prostate(1)	18				GBM - Glioblastoma multiforme(114;0.0614)		TGACATCCTTCCTTATGGTTT	0.333000													27	60					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41559078	41559078	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41559078C>T	ENST00000396942.1	-	22	2534	c.2451G>A	c.(2449-2451)tcG>tcA	p.S817S	ANK1_ENST00000352337.4_Silent_p.S817S|ANK1_ENST00000396945.1_Silent_p.S817S|ANK1_ENST00000289734.7_Silent_p.S817S|ANK1_ENST00000379758.2_Silent_p.S817S|ANK1_ENST00000265709.8_Silent_p.S850S|ANK1_ENST00000347528.4_Silent_p.S817S			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	817	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTTCATCTTCCGAGACATCCA	0.517000											OREG0018740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	86					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181726163	181726163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181726163C>T	ENST00000526775.1	+	29	4338	c.4173C>T	c.(4171-4173)ttC>ttT	p.F1391F	CACNA1E_ENST00000367567.4_Silent_p.F1017F|CACNA1E_ENST00000358338.5_Silent_p.F1342F|CACNA1E_ENST00000367570.1_Silent_p.F1410F|CACNA1E_ENST00000360108.3_Silent_p.F1391F|CACNA1E_ENST00000367573.2_Silent_p.F1410F|CACNA1E_ENST00000357570.5_Silent_p.F1361F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1410					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TTGTGGTCTTCCCCTTCTTCT	0.488000													46	94					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668411	176668411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176668411C>T	ENST00000367662.3	+	8	4086	c.2922C>T	c.(2920-2922)ttC>ttT	p.F974F		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	974					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CTTCCTTCTTCATGGAGTCCT	0.562000													80	180					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71483628	71483628	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71483628C>T	ENST00000393539.2	-	6	1113	c.300G>A	c.(298-300)aaG>aaA	p.K100K	ZNF23_ENST00000564528.1_Silent_p.K42K|ZNF23_ENST00000539742.1_5'UTR|RP11-510M2.10_ENST00000576258.1_RNA|ZNF23_ENST00000417828.1_Silent_p.K100K|ZNF23_ENST00000357254.4_Silent_p.K100K|AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000428724.2_Silent_p.K42K|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000497160.1_3'UTR	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		TGCTCTTCTCCTTCTTTATAT	0.408000													60	213					0	0	1	0	0
WNT7B	7477	broad.mit.edu	37	22	46318965	46318965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46318965G>A	ENST00000339464.4	-	4	1195	c.821C>T	c.(820-822)tCg>tTg	p.S274L	WNT7B_ENST00000409496.3_Missense_Mutation_p.S278L|WNT7B_ENST00000410089.1_Missense_Mutation_p.S258L	NM_058238.2	NP_478679.1	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family, member 7B	274					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	19		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		GTAGTTGGGCGACTTCTCAAT	0.667000													39	67					0	0	1	0	0
VPS35	55737	broad.mit.edu	37	16	46717501	46717501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:46717501G>A	ENST00000299138.7	-	2	79	c.21C>T	c.(19-21)tcC>tcT	p.S7S		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	7					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CATCCTGAGGGGACTGCTGTG	0.433000													5	28					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30938550	30938550	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30938550G>A	ENST00000597505.1	-	24	3318	c.3319C>T	c.(3319-3321)Cga>Tga	p.R1107*	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Nonsense_Mutation_p.R186*			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GCCTTCATTCGAAGATGAGCT	0.413000													35	57					0	0	1	0	0
XPNPEP3	63929	broad.mit.edu	37	22	41277899	41277899	+	Missense_Mutation	SNP	C	C	T	rs73885709		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41277899C>T	ENST00000357137.4	+	3	391	c.307C>T	c.(307-309)Cct>Tct	p.P103S	XPNPEP3_ENST00000414396.1_Missense_Mutation_p.P103S|XPNPEP3_ENST00000544094.1_Missense_Mutation_p.P80S|XPNPEP3_ENST00000541156.1_Missense_Mutation_p.P103S	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	103					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						GCTCTCCAACCCTACATACTA	0.463000													45	96					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6896531	6896531	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6896531G>A	ENST00000312053.4	+	3	254	c.217G>A	c.(217-219)Gat>Aat	p.D73N	EMR1_ENST00000601198.1_3'UTR|EMR1_ENST00000450315.3_Missense_Mutation_p.D73N|EMR1_ENST00000381404.4_Missense_Mutation_p.D73N|EMR1_ENST00000250572.8_Missense_Mutation_p.D73N|EMR1_ENST00000381407.5_Missense_Mutation_p.D73N	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	73	EGF-like 1.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TCACTTCAAGGATCCAGGAGT	0.478000													20	41					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39087996	39087996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39087996C>T	ENST00000591517.1	-	24	1835	c.1807G>A	c.(1807-1809)Gac>Aac	p.D603N	MAP4K1_ENST00000423454.2_3'UTR|MAP4K1_ENST00000396857.2_Missense_Mutation_p.D603N|MAP4K1_ENST00000589130.1_Missense_Mutation_p.D599N|CTB-186G2.1_ENST00000589557.1_RNA|MAP4K1_ENST00000586296.1_Intron	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	603	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CCTTTGGTGTCCTGGATCTTG	0.592000													30	311					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44015303	44015303	+	Silent	SNP	C	C	T	rs61732298		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44015303C>T	ENST00000269439.7	+	3	480	c.429C>T	c.(427-429)ttC>ttT	p.F143F	RNF165_ENST00000543885.1_Intron	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	143							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		ATCCCAGCTTCGACTTCGGCC	0.642000													17	57					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1271213	1271213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1271213G>A	ENST00000308624.5	+	14	1283	c.1154G>A	c.(1153-1155)aGg>aAg	p.R385K	SNTG2_ENST00000407292.1_Missense_Mutation_p.R258K	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	385	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GAGGACCAGAGGCCCTATTGC	0.512000													11	20					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123779149	123779149	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:123779149C>T	ENST00000422452.2	-	10	1783	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	TENM1_ENST00000371130.3_Missense_Mutation_p.E574K	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TGTCCTTTCTCGTATTCTCCA	0.498000													122	83					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104642755	104642755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104642755C>T	ENST00000315264.7	+	11	3591	c.3213C>T	c.(3211-3213)ctC>ctT	p.L1071L	KIF26A_ENST00000423312.2_Silent_p.L1210L			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1210					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		ACTCCAGCCTCCCCCGGAAAC	0.721000													9	13					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12826135	12826135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12826135G>A	ENST00000425528.1	-	8	927	c.570C>T	c.(568-570)tcC>tcT	p.S190S	TNPO2_ENST00000589956.1_Intron|TNPO2_ENST00000441499.1_Silent_p.S190S|TNPO2_ENST00000356861.5_Silent_p.S190S|TNPO2_ENST00000588216.1_Silent_p.S190S|TNPO2_ENST00000450764.2_Silent_p.S190S|TNPO2_ENST00000592287.1_Silent_p.S190S			O14787	TNPO2_HUMAN	transportin 2	190					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGATGGCGTGGGACCTGGCGG	0.662000													12	25					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78547308	78547308	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78547308A>C	ENST00000545128.1	+	2	744	c.206A>C	c.(205-207)aAg>aCg	p.K69T	PCSK5_ENST00000376752.4_Missense_Mutation_p.K69T|PCSK5_ENST00000376767.3_Missense_Mutation_p.K69T	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	69					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GGGGCCCTGAAGGACTACTAC	0.408000													22	45					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	167012436	167012436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:167012436C>T	ENST00000061240.2	+	19	3246	c.2599C>T	c.(2599-2601)Cgg>Tgg	p.R867W	TLL1_ENST00000507499.1_Missense_Mutation_p.R890W	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	867	CUB 4.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.R867W(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AATGTTTGTTCGGTTTGTTTC	0.403000													30	69					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9624925	9624925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9624925C>T	ENST00000378429.3	-	4	598	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	PAK7_ENST00000378423.1_Missense_Mutation_p.E18K|PAK7_ENST00000353224.5_Missense_Mutation_p.E18K	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	18	CRIB.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			ACCCTGTGTTCAAAGTTGGAC	0.448000													31	87					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201438338	201438338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:201438338C>T	ENST00000357799.4	+	7	3367	c.3269C>T	c.(3268-3270)cCa>cTa	p.P1090L		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	1090					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						GATCCTTCTCCAGAGAGCCAT	0.368000													55	109					0	0	1	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455657	187455657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187455657G>A	ENST00000307161.5	-	2	440	c.239C>T	c.(238-240)cCg>cTg	p.P80L	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	80					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	CAACGGGTACGGATAAATGGC	0.502000													21	49					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439631	52439631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52439631G>A	ENST00000242819.4	+	2	413	c.117G>A	c.(115-117)aaG>aaA	p.K39K		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	39						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		TTCGCCAGAAGAAACTAATGC	0.488000													24	87					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7012458	7012458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:7012458C>T	ENST00000409757.4	+	11	1721	c.1597C>T	c.(1597-1599)Ctt>Ttt	p.L533F	TBC1D14_ENST00000448507.1_Missense_Mutation_p.L533F|TBC1D14_ENST00000410031.1_Missense_Mutation_p.L305F|TBC1D14_ENST00000451522.2_Missense_Mutation_p.L253F|TBC1D14_ENST00000446947.2_Missense_Mutation_p.L180F	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	533	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						CTTTTCTAACCTTCTGAATAA	0.458000													47	123					0	0	1	0	0
MDFI	4188	broad.mit.edu	37	6	41617481	41617481	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41617481G>A	ENST00000373050.4	+	3	388	c.201G>A	c.(199-201)cgG>cgA	p.R67R				Q99750	MDFI_HUMAN	MyoD family inhibitor	128					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			AGGCCCACCGGAAGTTGCAGA	0.647000													68	141					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74019403	74019403	+	Silent	SNP	G	G	A	rs148972745		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74019403G>A	ENST00000301607.3	-	4	703	c.450C>T	c.(448-450)gtC>gtT	p.V150V	EVPL_ENST00000586740.1_Silent_p.V150V	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	150	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GTGCCCAGTCGACCCTGGGTC	0.607000													38	90					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520248	131520248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131520248C>T	ENST00000423981.1	+	2	713	c.603C>T	c.(601-603)ttC>ttT	p.F201F	AMER3_ENST00000321420.4_Silent_p.F201F	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GCAAAGCCTTCCTCCCCCCGG	0.687000													20	47					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34164424	34164424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34164424C>T	ENST00000373381.4	-	24	4030	c.3854G>A	c.(3853-3855)cGg>cAg	p.R1285Q	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.R158Q	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1245	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTCACTACCCCGCAGGCTGTA	0.607000													10	105					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68156997	68156997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68156997C>T	ENST00000349223.5	+	2	1435	c.1211C>T	c.(1210-1212)cCa>cTa	p.P404L	NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.P404L|NFATC3_ENST00000329524.4_Missense_Mutation_p.P404L|NFATC3_ENST00000575270.1_Missense_Mutation_p.P404L	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	404					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		TGGAGCAAACCAAAGCCTGGC	0.413000													28	124					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19575479	19575479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:19575479C>T	ENST00000328405.2	+	16	3478	c.3212C>T	c.(3211-3213)tCt>tTt	p.S1071F		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	1071						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						TTACCAGGATCTTGGAACCAG	0.473000													19	50					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359505	66359505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66359505G>A	ENST00000333861.3	-	1	1049	c.982C>T	c.(982-984)Cct>Tct	p.P328S		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	328										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GGGAGTGGAGGAAGGCCCAAC	0.617000													12	66					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88402646	88402646	+	Missense_Mutation	SNP	C	C	T	rs146646005		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:88402646C>T	ENST00000419482.2	+	7	1043	c.958C>T	c.(958-960)Cgt>Tgt	p.R320C	SMYD1_ENST00000444564.2_Missense_Mutation_p.R307C|SMYD1_ENST00000438570.1_Intron	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						AGACAAGGCTCGTTCCGAGGG	0.463000													21	35					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92085731	92085731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92085731G>A	ENST00000298047.6	+	1	470	c.453G>A	c.(451-453)atG>atA	p.M151I	FAT3_ENST00000541502.1_Missense_Mutation_p.M151I|FAT3_ENST00000409404.2_Missense_Mutation_p.M151I|FAT3_ENST00000525166.1_Start_Codon_SNP_p.M1I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	151	Cadherin 1.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTTAGATATGAATGATCTGA	0.403000										TCGA Ovarian(4;0.039)			25	46					0	0	1	0	0
HMGCR	3156	broad.mit.edu	37	5	74655281	74655281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:74655281C>T	ENST00000287936.4	+	18	2513	c.2357C>T	c.(2356-2358)cCc>cTc	p.P786L	HMGCR_ENST00000511206.1_Missense_Mutation_p.P786L|HMGCR_ENST00000343975.5_Missense_Mutation_p.P733L	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	786	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GCAAGTGGTCCCACAAATGAA	0.403000													11	74					0	0	1	0	0
ZDHHC1	29800	broad.mit.edu	37	16	67440214	67440214	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67440214G>A	ENST00000348579.2	-	3	482	c.141C>T	c.(139-141)ccC>ccT	p.P47P		NM_013304.2	NP_037436.1	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	47						integral to membrane	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|urinary_tract(1)	10		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		GCGGGTGAGGGGGCCAGCTCC	0.667000													5	12					0	0	1	0	0
CDK3	1018	broad.mit.edu	37	17	73998208	73998208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73998208C>T	ENST00000425876.2	+	3	388	c.300C>T	c.(298-300)ccC>ccT	p.P100P	TEN1-CDK3_ENST00000567351.1_RNA|CDK3_ENST00000448471.1_Silent_p.P100P			Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	100	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						CAGAGCTCCCCCTGCACCTCA	0.597000													20	56					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228487768	228487768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228487768G>A	ENST00000570156.2	+	51	13734	c.13660G>A	c.(13660-13662)Ggc>Agc	p.G4554S	OBSCN_ENST00000366707.4_Missense_Mutation_p.G1244S|RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000359599.6_3'UTR|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000602685.1_3'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3597	Fibronectin type-III 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCAGATTCGTGGCCTGGTCAT	0.587000													28	62					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013558	75013558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75013558G>A	ENST00000379727.3	-	5	1346	c.1148C>T	c.(1147-1149)cCc>cTc	p.P383L	CYP1A1_ENST00000395049.4_Missense_Mutation_p.P383L|CYP1A1_ENST00000567032.1_Missense_Mutation_p.P383L|CYP1A1_ENST00000395048.2_Missense_Mutation_p.P383L|CYP1A1_ENST00000564596.1_Missense_Mutation_p.P122L			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	383					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	GATGGTGAAGGGGACGAAGGA	0.577000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				44	147					0	0	1	0	0
MVP	9961	broad.mit.edu	37	16	29856019	29856019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29856019C>T	ENST00000357402.5	+	11	1978	c.1840C>T	c.(1840-1842)Ccc>Tcc	p.P614S	MVP_ENST00000395353.1_Missense_Mutation_p.P614S	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	614					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						AGCGAAGGGCCCCGATGGCAT	0.622000													53	122					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13418659	13418659	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13418659G>A	ENST00000360228.5	-	15	1922	c.1923C>T	c.(1921-1923)ttC>ttT	p.F641F	CACNA1A_ENST00000573710.2_Silent_p.F642F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	642					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCCCTTCATCGAAATTAAACC	0.547000													19	91					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644608	169644608	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169644608A>T	ENST00000428432.2	+	6	947	c.558A>T	c.(556-558)aaA>aaT	p.K186N	SAMD7_ENST00000335556.3_Missense_Mutation_p.K186N	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	186										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GACTCAGGAAAAATACAGGGA	0.483000													29	74					0	0	1	0	0
KCNE1L	23630	broad.mit.edu	37	X	108867989	108867989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:108867989G>A	ENST00000372101.2	-	1	404	c.261C>T	c.(259-261)ctC>ctT	p.L87L	RP1-136J15.3_ENST00000439581.1_RNA	NM_012282.2	NP_036414.1	Q9UJ90	KCE1L_HUMAN	KCNE1-like	87					regulation of heart contraction	voltage-gated potassium channel complex				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6						TGGCCTCGACGAGCTTACGGG	0.687000													4	20					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214815813	214815813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:214815813C>T	ENST00000366955.3	+	12	4300	c.4132C>T	c.(4132-4134)Cct>Tct	p.P1378S		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1475					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGAACAGCACCCTGTGTCTTT	0.408000													6	68					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129281993	129281993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129281993G>A	ENST00000393239.1	-	26	4790	c.4612C>T	c.(4612-4614)Cgc>Tgc	p.R1538C	PLXND1_ENST00000324093.4_Missense_Mutation_p.R1538C			Q9Y4D7	PLXD1_HUMAN	plexin D1	1538					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						AGTGTGTAGCGGGCCTTGCCT	0.642000													6	34					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14819293	14819293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14819293C>T	ENST00000380881.4	-	15	3303	c.2488G>A	c.(2488-2490)Gga>Aga	p.G830R	FREM1_ENST00000422223.2_Missense_Mutation_p.G829R|FREM1_ENST00000380880.3_Missense_Mutation_p.G829R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	829					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGAGGAAATCCATTCAGCTCC	0.433000													6	43					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143098605	143098605	+	Missense_Mutation	SNP	G	G	A	rs74721927	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143098605G>A	ENST00000275815.3	-	3	330	c.244C>T	c.(244-246)Cgc>Tgc	p.R82C		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	82						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CAATTGGAGCGAAGCCAGTGG	0.602000													20	249					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95090041	95090041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95090041G>A	ENST00000553947.1	+	8	2125	c.1237G>A	c.(1237-1239)Gag>Aag	p.E413K	SERPINA3_ENST00000467132.1_Missense_Mutation_p.E388K|SERPINA3_ENST00000482740.1_Missense_Mutation_p.E170K|SERPINA3_ENST00000393080.4_Missense_Mutation_p.E388K|SERPINA3_ENST00000393078.3_Missense_Mutation_p.E388K			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	388					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TGCATTAGTGGAGACAAGGAC	0.493000													37	100					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167796359	167796359	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:167796359C>T	ENST00000366827.2	-	2	214	c.3G>A	c.(1-3)atG>atA	p.M1I	TCP10_ENST00000476779.2_Start_Codon_SNP_p.M1I|TCP10_ENST00000397829.4_Start_Codon_SNP_p.M1I			Q12799	TCP10_HUMAN	t-complex 10	28						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		GTGTCTTCTCCATGGCAGCCC	0.662000													5	10					0	0	1	0	0
KIAA1586	57691	broad.mit.edu	37	6	56918271	56918271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56918271C>T	ENST00000370733.4	+	4	1181	c.974C>T	c.(973-975)tCa>tTa	p.S325L	KIAA1586_ENST00000545356.1_Missense_Mutation_p.S298L	NM_020931.2	NP_065982.1	Q9HCI6	K1586_HUMAN	KIAA1586	325							nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)	18	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TCTACAGTTTCAAAGAAAACC	0.338000													45	139					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107517425	107517425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:107517425C>T	ENST00000416476.2	+	15	1620	c.1400C>T	c.(1399-1401)tCc>tTc	p.S467F	BBX_ENST00000415149.2_Silent_p.I773I|BBX_ENST00000325805.8_Silent_p.I803I|BBX_ENST00000473542.1_3'UTR|BBX_ENST00000406780.1_Silent_p.I773I|BBX_ENST00000402543.1_Silent_p.I753I			Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	0	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TTAAAAATATCCCATCCATTT	0.403000													26	79					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735280	13735280	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13735280C>T	ENST00000265104.4	-	68	11825	c.11721G>A	c.(11719-11721)agG>agA	p.R3907R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3907					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGACTCGGTTCCTCTGGATGT	0.438000									Kartagener syndrome				8	86					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123599966	123599966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123599966C>T	ENST00000340011.5	+	5	1830	c.1473C>T	c.(1471-1473)gcC>gcT	p.A491A	SPAM1_ENST00000460182.1_Silent_p.A491A|SPAM1_ENST00000439500.1_Silent_p.A491A|SPAM1_ENST00000223028.7_Silent_p.A491A|SPAM1_ENST00000402183.2_Silent_p.A491A	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	491					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	CACTATCTGCCACAATGTTCA	0.373000													33	74					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238053390	238053390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:238053390C>T	ENST00000366570.4	-	2	420	c.262G>A	c.(262-264)Gag>Aag	p.E88K	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	88					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TAGGTTGCCTCCAACACCACG	0.582000													38	88					0	0	1	0	0
TBC1D17	79735	broad.mit.edu	37	19	50391759	50391759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50391759C>T	ENST00000221543.5	+	17	2124	c.1825C>T	c.(1825-1827)Ccg>Tcg	p.P609S	TBC1D17_ENST00000535102.2_Missense_Mutation_p.P576S	NM_024682.2	NP_078958.2	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	609	Pro-rich.					intracellular	Rab GTPase activator activity			NS(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CACCGCCTCCCCGCTGCCTCT	0.746000													3	12					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247694899	247694899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247694899C>T	ENST00000366487.3	-	2	1276	c.915G>A	c.(913-915)atG>atA	p.M305I	GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000527541.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TCTCTAATACCATGTGCCGGA	0.507000													18	48					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185012502	185012502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:185012502C>T	ENST00000296741.2	-	8	1292	c.1151G>A	c.(1150-1152)aGg>aAg	p.R384K		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	384					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GTCCACCGACCTGATAGGAGC	0.542000													8	98					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145109485	145109485	+	Missense_Mutation	SNP	C	C	T	rs149290437	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145109485C>T	ENST00000426825.1	-	19	2746	c.2665G>A	c.(2665-2667)Ggg>Agg	p.G889R	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	889							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	AAGACGCCCCCCTGGACAAGT	0.647000													6	17					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94882608	94882608	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94882608G>A	ENST00000331706.4	+	0	792				MCTP2_ENST00000543482.1_Missense_Mutation_p.D243N|MCTP2_ENST00000451018.3_Missense_Mutation_p.D243N|MCTP2_ENST00000357742.4_Missense_Mutation_p.D243N			Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CCCAGTATGGGATGAGATAGT	0.358000													43	145					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120332	38120332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38120332C>T	ENST00000406386.3	+	7	2024	c.1769C>T	c.(1768-1770)cCc>cTc	p.P590L	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	590					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GCCTCCTCTCCCAATAGAGCT	0.572000													45	223					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294023	124294023	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124294023G>A	ENST00000356130.3	-	1	766	c.745C>T	c.(745-747)Ctg>Ttg	p.L249L		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CCAAAAAACAGAGCAACAGCA	0.458000													7	64					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32526728	32526728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32526728G>A	ENST00000286827.3	-	18	3479	c.3008C>T	c.(3007-3009)gCc>gTc	p.A1003V	TIAM1_ENST00000541036.1_Missense_Mutation_p.A943V	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1003					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GCAAAATGCGGCCACCTGTTC	0.582000													27	70					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234878915	234878915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234878915C>T	ENST00000324695.4	+	17	2240	c.2200C>T	c.(2200-2202)Ccc>Tcc	p.P734S	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	734						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTTCACCTCCCCCTTCGTGGT	0.537000													91	250					0	0	1	0	0
FSHB	2488	broad.mit.edu	37	11	30255248	30255248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30255248C>T	ENST00000417547.1	+	3	330	c.291C>T	c.(289-291)gcC>gcT	p.A97A	FSHB_ENST00000254122.3_Silent_p.A97A|FSHB_ENST00000533718.1_Silent_p.A97A	NM_001018080.1	NP_001018090.1	P01225	FSHB_HUMAN	follicle stimulating hormone, beta polypeptide	97					cellular nitrogen compound metabolic process|female gamete generation|female pregnancy|ovarian follicle development|peptide hormone processing|progesterone biosynthetic process|spermatogenesis|transforming growth factor beta receptor signaling pathway	cytoplasm|extracellular region|soluble fraction	follicle-stimulating hormone activity|protein heterodimerization activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(3)|skin(1)	12					Follitropin beta(DB00066)|Thyrotropin Alfa(DB00024)|Urofollitropin(DB00094)	ACCCAGTGGCCACCCAGTGTC	0.498000													17	36					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97167502	97167502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97167502C>T	ENST00000389672.5	+	7	1860	c.1822C>T	c.(1822-1824)Cac>Tac	p.H608Y	EPHA6_ENST00000514100.1_5'UTR|EPHA6_ENST00000442602.2_5'UTR|EPHA6_ENST00000502694.1_5'UTR	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	513						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						ATATGTATTTCACATCCGAGT	0.443000													13	100					0	0	1	0	0
FXYD5	53827	broad.mit.edu	37	19	35657175	35657175	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35657175G>A	ENST00000342879.3	+	7	1212	c.434G>A	c.(433-435)cGg>cAg	p.R145Q	FXYD5_ENST00000392217.3_Missense_Mutation_p.R74Q|FXYD5_ENST00000590686.1_Missense_Mutation_p.R145Q|FXYD5_ENST00000588699.1_Missense_Mutation_p.R145Q|FXYD5_ENST00000591716.2_3'UTR|FXYD5_ENST00000543307.1_Missense_Mutation_p.R145Q|FXYD5_ENST00000541435.2_Missense_Mutation_p.R145Q|FXYD5_ENST00000423817.3_Missense_Mutation_p.R145Q|FXYD5_ENST00000392219.2_Missense_Mutation_p.R145Q			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	145					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CTCCGGAAACGGGGGCTGTTG	0.547000													72	270					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537901	55537901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55537901G>A	ENST00000220676.1	+	4	1607	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	487					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCATATAGTGAAGAAAGGGA	0.363000													28	67					0	0	1	0	0
RNF175	285533	broad.mit.edu	37	4	154633721	154633721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:154633721C>T	ENST00000347063.4	-	8	1144	c.772G>A	c.(772-774)Gaa>Aaa	p.E258K		NM_173662.2	NP_775933.1	Q8N4F7	RN175_HUMAN	ring finger protein 175	258						integral to membrane	zinc ion binding			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	13	all_hematologic(180;0.093)	Renal(120;0.118)				ATGCAGAATTCATGAAAGCTG	0.438000													3	20					0	0	1	0	0
ABCG1	9619	broad.mit.edu	37	21	43716295	43716295	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43716295C>T	ENST00000398437.1	+	16	2416	c.2268C>T	c.(2266-2268)atC>atT	p.I756I	ABCG1_ENST00000398449.3_Silent_p.I598I|ABCG1_ENST00000343687.3_Silent_p.I609I|ABCG1_ENST00000361802.2_Silent_p.I610I|ABCG1_ENST00000340588.4_Silent_p.I718I|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000398457.2_Silent_p.I600I|ABCG1_ENST00000347800.2_Silent_p.I595I			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	610					amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	AAGGGGTCATCCTCTCCATCT	0.592000													24	55					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37271906	37271906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:37271906C>T	ENST00000373091.3	-	14	2129	c.2113G>A	c.(2113-2115)Gag>Aag	p.E705K	GRIK3_ENST00000373093.4_Missense_Mutation_p.E705K	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	705					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CACATCTTCTCGAAGGTGGAG	0.602000													7	28					0	0	1	0	0
REPIN1	29803	broad.mit.edu	37	7	150069245	150069245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150069245C>T	ENST00000397281.2	+	4	1404	c.915C>T	c.(913-915)ccC>ccT	p.P305P	REPIN1_ENST00000444957.1_Silent_p.P305P|REPIN1_ENST00000489432.2_Silent_p.P362P|REPIN1_ENST00000479668.1_3'UTR|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000425389.2_Silent_p.P305P|REPIN1_ENST00000540729.1_Silent_p.P305P	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	305					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			GGCACAAACCCAACCTGCTGT	0.672000													11	16					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57148260	57148260	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:57148260G>A	ENST00000376149.3	-	9	1176	c.367C>T	c.(367-369)Ctt>Ttt	p.L123F	TRIM37_ENST00000262294.7_Missense_Mutation_p.L245F|TRIM37_ENST00000393065.2_Missense_Mutation_p.L211F|TRIM37_ENST00000393066.3_Missense_Mutation_p.L245F			O94972	TRI37_HUMAN	tripartite motif containing 37	245						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AACATCATAAGGATCTCTGAG	0.388000									Mulibrey Nanism				25	70					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21136605	21136605	+	Missense_Mutation	SNP	C	C	T	rs139455188	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21136605C>T	ENST00000261383.3	-	9	1294	c.1295G>A	c.(1294-1296)cGa>cAa	p.R432Q	DNAH3_ENST00000415178.1_Missense_Mutation_p.R432Q|CTC-508F8.1_ENST00000575612.1_RNA	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	432	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R432Q(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CTCAATGTTTCGACTTGAGTC	0.473000													21	84					0	0	1	0	0
DEFA4	1669	broad.mit.edu	37	8	6793654	6793654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:6793654C>T	ENST00000297435.2	-	3	306	c.182G>A	c.(181-183)aGg>aAg	p.R61K		NM_001925.1	NP_001916.1	P12838	DEF4_HUMAN	defensin, alpha 4, corticostatin	61					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	10				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		GACCATGCCCCTTGTTGAGCC	0.517000													9	47					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55268032	55268032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55268032C>T	ENST00000275493.2	+	24	3049	c.2872C>T	c.(2872-2874)Cgc>Tgc	p.R958C	EGFR_ENST00000454757.2_Missense_Mutation_p.R905C|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_Missense_Mutation_p.R913C	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	958	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCAGATAGTCGCCCAAAGTT	0.458000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			29	101					0	0	1	0	0
SSUH2	51066	broad.mit.edu	37	3	8675490	8675490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:8675490G>A	ENST00000317371.4	-	11	1360	c.135C>T	c.(133-135)gtC>gtT	p.V45V	SSUH2_ENST00000544814.1_Intron|SSUH2_ENST00000415132.1_Silent_p.V45V|SSUH2_ENST00000341795.3_Silent_p.V45V					ssu-2 homolog (C. elegans)																		CTCTGCAGGGGACCGAACAGA	0.652000													9	22					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29365268	29365268	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29365268G>A	ENST00000383555.2	+	1	853	c.792G>A	c.(790-792)gaG>gaA	p.E264E	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E264D(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						CTGCGTTAGAGAGCTTCATGG	0.458000													70	163					0	0	1	0	0
GHITM	27069	broad.mit.edu	37	10	85904638	85904638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85904638C>T	ENST00000372134.3	+	5	542	c.349C>T	c.(349-351)Cct>Tct	p.P117S		NM_014394.2	NP_055209.2	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	117					apoptosis	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(2)	10						CAGAATTTGGCCTCAGTATGT	0.398000													10	85					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519973	113519973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113519973C>T	ENST00000284601.3	-	4	1242	c.1174G>A	c.(1174-1176)Gaa>Aaa	p.E392K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	392					glycogen metabolic process	integral to membrane		p.E392K(1)		NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GAATATTTTTCATTGCAGTAA	0.398000													66	147					0	0	1	0	0
METTL22	79091	broad.mit.edu	37	16	8736037	8736037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:8736037C>T	ENST00000381920.3	+	8	1138	c.880C>T	c.(880-882)Cac>Tac	p.H294Y	METTL22_ENST00000568967.1_3'UTR|METTL22_ENST00000561758.1_Missense_Mutation_p.H238Y	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	294							methyltransferase activity			large_intestine(5)|lung(4)	9						CTTGTACGATCACACCACCAT	0.468000													10	87					0	0	1	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3386026	3386026	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3386026C>T	ENST00000378378.4	+	6	1296	c.891C>T	c.(889-891)ttC>ttT	p.F297F	ARHGEF16_ENST00000378371.2_Silent_p.F9F|ARHGEF16_ENST00000378373.1_Silent_p.F9F	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	297	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		CGTCGGAGTTCTCCTACCAGC	0.627000													18	63					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123842627	123842627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123842627C>T	ENST00000369005.1	+	4	952	c.612C>T	c.(610-612)ccC>ccT	p.P204P	TACC2_ENST00000334433.3_Silent_p.P204P|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Silent_p.P204P|TACC2_ENST00000515273.1_Silent_p.P204P|TACC2_ENST00000453444.2_Silent_p.P204P	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	204						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CGCCAGTACCCCTCAGAGAGC	0.582000													4	46					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71036968	71036968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:71036968G>A	ENST00000452400.2	-	20	4230	c.4049C>T	c.(4048-4050)cCc>cTc	p.P1350L	NCOA2_ENST00000267974.4_Missense_Mutation_p.P438L	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1350					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TATGTCGGAGGGGGCCTGATA	0.562000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								8	52					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77171000	77171000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:77171000C>T	ENST00000253506.5	+	2	1094	c.725C>T	c.(724-726)cCc>cTc	p.P242L	NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000587635.1_Missense_Mutation_p.P242L|NFATC1_ENST00000329101.4_Missense_Mutation_p.P229L|NFATC1_ENST00000591814.1_Missense_Mutation_p.P242L|NFATC1_ENST00000586434.1_Missense_Mutation_p.P229L|NFATC1_ENST00000592223.1_Missense_Mutation_p.P229L|NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000542384.1_Missense_Mutation_p.P242L|NFATC1_ENST00000427363.2_Missense_Mutation_p.P242L|NFATC1_ENST00000318065.5_Missense_Mutation_p.P229L	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	242	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		TCCACCTCGCCCCGCGCCAGC	0.711000													6	39					0	0	1	0	0
LRRC37A5P	652972	broad.mit.edu	37	9	114371455	114371455	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114371455C>T	ENST00000374304.1	-	0	344																											AGTCCGTCTTCAAGGTCCGGA	0.498000													16	126					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125131980	125131980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125131980C>T	ENST00000522917.1	+	41	5729	c.5523C>T	c.(5521-5523)ttC>ttT	p.F1841F	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Silent_p.F1841F	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1841						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			tcgtccttttcatcTACACCT	0.463000													34	137					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14156999	14156999	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:14156999G>A	ENST00000310358.7	+	0	1245							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		ATCATCGGAGGATCCCACTCC	0.507000													20	66					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43930230	43930230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43930230C>T	ENST00000261488.6	-	8	1225	c.648G>A	c.(646-648)gtG>gtA	p.V216V	ENOX1_ENST00000540032.1_Silent_p.V29V|ENOX1_ENST00000412891.1_Silent_p.V216V	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	216	RRM.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GGGCAAAGTCCACATGAAGGC	0.547000													17	59					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21564648	21564648	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21564648G>A	ENST00000415912.2	-	11	1445	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F	ECE1_ENST00000374893.6_Silent_p.F456F|ECE1_ENST00000528294.1_5'UTR|ECE1_ENST00000436918.2_Silent_p.F456F|ECE1_ENST00000264205.6_Silent_p.F453F|ECE1_ENST00000357071.4_Silent_p.F444F	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	456					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		TGTCCTCGGCGAAGGTTGCTT	0.542000													23	58					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101086823	101086823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:101086823G>A	ENST00000394095.2	-	8	882	c.829C>T	c.(829-831)Ctc>Ttc	p.L277F	SENP7_ENST00000358203.3_Missense_Mutation_p.L113F|SENP7_ENST00000314261.7_Missense_Mutation_p.L211F|SENP7_ENST00000348610.3_Missense_Mutation_p.L244F|SENP7_ENST00000394091.1_Missense_Mutation_p.L113F|SENP7_ENST00000394094.2_Missense_Mutation_p.L212F	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	277					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TCCTGTTCGAGATGATCACAA	0.338000													28	88					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25406065	25406065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25406065G>A	ENST00000255324.5	+	18	2483	c.2431G>A	c.(2431-2433)Gaa>Aaa	p.E811K	RNF17_ENST00000381921.1_Missense_Mutation_p.E811K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	811					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AGAAGCTAAAGAAAAATTTGA	0.289000													23	39					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41797425	41797425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41797425C>T	ENST00000263800.6	-	15	2002	c.1906G>A	c.(1906-1908)Gaa>Aaa	p.E636K	LTK_ENST00000355166.5_Missense_Mutation_p.E575K|LTK_ENST00000453182.2_Missense_Mutation_p.E506K|LTK_ENST00000561619.1_Missense_Mutation_p.E334K	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	636	Protein kinase.				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		AAGTGATTTTCCTCCAGGTAG	0.602000										TSP Lung(18;0.14)			33	20					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70951717	70951717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70951717G>A	ENST00000357250.6	-	30	2106	c.1948C>T	c.(1948-1950)Ctc>Ttc	p.L650F	COL9A1_ENST00000370499.4_Missense_Mutation_p.L407F|RP1-149L1.1_ENST00000522264.1_RNA|COL9A1_ENST00000320755.7_Missense_Mutation_p.L407F|COL9A1_ENST00000489611.1_Intron	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	650	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AAGCCAGGGAGGCCAGGGCTA	0.532000													6	9					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25258636	25258636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:25258636G>A	ENST00000328086.7	-	5	1684	c.881C>T	c.(880-882)tCc>tTc	p.S294F		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	294	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		CTTGTTAGAGGAATGCAGACC	0.428000													9	94					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33998741	33998741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33998741G>A	ENST00000373381.4	-	64	10256	c.10080C>T	c.(10078-10080)tcC>tcT	p.S3360S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3216						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTCCTGGCAGGAGTAGATGA	0.652000													11	27					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31577457	31577457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31577457G>A	ENST00000356173.3	-	9	674	c.582C>T	c.(580-582)atC>atT	p.I194I	SUN5_ENST00000375523.3_Silent_p.I169I	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	194					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						CTGGCTTTTCGATGTAATCTC	0.483000													15	55					0	0	1	0	0
ANKRD54	129138	broad.mit.edu	37	22	38234576	38234576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38234576G>A	ENST00000215941.4	-	3	598	c.406C>T	c.(406-408)Ccc>Tcc	p.P136S	ANKRD54_ENST00000411961.2_Missense_Mutation_p.P120S|ANKRD54_ENST00000406423.1_Missense_Mutation_p.P16S	NM_138797.2	NP_620152.1	Q6NXT1	ANR54_HUMAN	ankyrin repeat domain 54	136										lung(1)	1	Melanoma(58;0.045)					GCTGCACAGGGATCCGCGCCA	0.592000													3	19					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39066565	39066565	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39066565C>T	ENST00000355481.4	+	96	14252	c.14121C>T	c.(14119-14121)ttC>ttT	p.F4707F	RYR1_ENST00000360985.3_Silent_p.F4707F|RYR1_ENST00000359596.3_Silent_p.F4712F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4712					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCAGGTCTTTCCCTAGCAACT	0.557000													28	70					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47538911	47538911	+	Missense_Mutation	SNP	G	G	A	rs149876632		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47538911G>A	ENST00000273859.3	+	9	1621	c.1352G>A	c.(1351-1353)cGa>cAa	p.R451Q	ATP10D_ENST00000504445.1_Missense_Mutation_p.R436Q	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	451					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						ATGGTTTTTCGAAGATGTAGT	0.443000													24	24					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46657680	46657680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46657680C>T	ENST00000253255.5	-	1	1539	c.1540G>A	c.(1540-1542)Gga>Aga	p.G514R		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	514	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CCATTCCTTCCTGTTACAGTT	0.388000													89	217					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105831820	105831820	+	Nonsense_Mutation	SNP	G	G	A	rs121912774		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105831820G>A	ENST00000353479.5	-	8	723	c.433C>T	c.(433-435)Cga>Tga	p.R145*	COL17A1_ENST00000369733.3_Nonsense_Mutation_p.R145*|COL17A1_ENST00000393211.3_Nonsense_Mutation_p.R145*	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	145	Necessary for interaction with DST and for the recruitment of DST to hemidesmosome.|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CTCTGCAGTCGAACTCGAATT	0.488000													23	36					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1785174	1785174	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1785174C>T	ENST00000539485.1	-	27	3779	c.3546G>A	c.(3544-3546)acG>acA	p.T1182T	ATP8B3_ENST00000310127.6_Silent_p.T1172T|ATP8B3_ENST00000525591.1_Silent_p.T1135T			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	1172					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGGGAAGGTCGTGGGGGATA	0.617000													4	7					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94068088	94068088	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:94068088G>A	ENST00000369303.4	-	4	1058	c.874C>T	c.(874-876)Cag>Tag	p.Q292*		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	292	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CGAGAGCACTGAAGATCTTGA	0.433000													9	41					0	0	1	0	0
DIO2	1734	broad.mit.edu	37	14	80669428	80669428	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:80669428G>A	ENST00000557125.1	-	2	49	c.48_splice	c.e2-1	p.P17_splice	DIO2_ENST00000422005.3_3'UTR|DIO2_ENST00000438257.4_Silent_p.A142A|DIO2_ENST00000557010.1_Silent_p.A142A|DIO2_ENST00000555750.1_Silent_p.A178A			Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	0					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding	p.A178A(1)|p.A142A(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		GTTTGCGGAAGGCTGGCAGCT	0.572000											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	21					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50282174	50282174	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:50282174C>T	ENST00000404971.1	-	21	5186	c.3847G>A	c.(3847-3849)Gat>Aat	p.D1283N	NRXN1_ENST00000402717.3_Missense_Mutation_p.D1235N|NRXN1_ENST00000401710.1_Intron|NRXN1_ENST00000401669.2_Missense_Mutation_p.D1243N|NRXN1_ENST00000406859.3_Intron|NRXN1_ENST00000405472.3_Missense_Mutation_p.D1235N|NRXN1_ENST00000342183.5_Intron|NRXN1_ENST00000406316.2_Intron	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1239	Laminin G-like 6.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CGCTCGTTATCATTGTTTCCT	0.358000													10	22					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28997133	28997133	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:28997133G>A	ENST00000322982.3	-	0	801							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GTTGCCCAAGGGAGCGAAGAC	0.652000													11	33					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	110222987	110222987	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110222987G>A	ENST00000399132.1	-	2	719	c.189C>T	c.(187-189)atC>atT	p.I63I	COL25A1_ENST00000399127.1_Silent_p.I63I|COL25A1_ENST00000399126.1_Silent_p.I63I	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	63						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CGAGAGCGGCGATCCTCGCCT	0.607000													11	149					0	0	1	0	0
ABCB7	22	broad.mit.edu	37	X	74284974	74284974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:74284974G>A	ENST00000253577.3	-	13	1789	c.1765C>T	c.(1765-1767)Cat>Tat	p.H589Y	ABCB7_ENST00000373394.3_Missense_Mutation_p.H588Y|ABCB7_ENST00000339447.4_Missense_Mutation_p.H548Y	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	588	ABC transporter.				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity	p.H589Y(1)		breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						ATTGCATCATGAAGTCCAGCT	0.433000													18	12					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32415222	32415222	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:32415222G>A	ENST00000265069.8	-	5	738	c.636C>T	c.(634-636)gcC>gcT	p.A212A		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	212	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		CTGGTTTTATGGCTGTCACTT	0.498000													21	55					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61829395	61829395	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61829395C>T	ENST00000280772.1	-	37	11435	c.11244G>A	c.(11242-11244)gtG>gtA	p.V3748V	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3748					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AACTGGTCATCACCGCTTCTA	0.418000													60	156					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47692738	47692738	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47692738G>A	ENST00000397708.1	-	9	2456	c.2202C>T	c.(2200-2202)atC>atT	p.I734I	MCM3AP_ENST00000291688.1_Silent_p.I734I			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	734					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					GCTGCTGCGTGATATCCTGGC	0.547000													27	56					0	0	1	0	0
SLC7A3	84889	broad.mit.edu	37	X	70145692	70145692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70145692G>A	ENST00000374299.3	-	12	1975	c.1831C>T	c.(1831-1833)Ccc>Tcc	p.P611S	SLC7A3_ENST00000298085.4_Missense_Mutation_p.P611S			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	611					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	AGAGTGCCGGGATCAAGGTCT	0.498000													29	21					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133196570	133196570	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133196570C>T	ENST00000388996.4	-	3	942	c.522G>A	c.(520-522)agG>agA	p.R174R	KCNQ3_ENST00000519445.1_Silent_p.R174R|KCNQ3_ENST00000521134.1_Silent_p.R54R	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	174					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CAGCCCAGATCCTCAAAGCAA	0.532000													38	94					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153149857	153149857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153149857C>T	ENST00000285900.5	+	13	2495	c.2152C>T	c.(2152-2154)Ctg>Ttg	p.L718L	GRIA1_ENST00000518783.1_Silent_p.L728L|GRIA1_ENST00000521843.2_Silent_p.L649L|GRIA1_ENST00000340592.5_Silent_p.L718L|GRIA1_ENST00000448073.4_Silent_p.L728L|GRIA1_ENST00000518142.1_Silent_p.L638L	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	718					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGCCTACCTCCTGGAGTCCAC	0.498000													16	46					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11289038	11289038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11289038G>A	ENST00000432929.2	-	6	1887	c.1527C>T	c.(1525-1527)ttC>ttT	p.F509F	KANK2_ENST00000355150.5_Silent_p.F501F|KANK2_ENST00000586659.1_Silent_p.F501F|KANK2_ENST00000589894.1_Silent_p.F501F|KANK2_ENST00000589359.1_Silent_p.F509F	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	501										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TGACCCCCACGAACTGGAGGC	0.647000													13	16					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124050683	124050683	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124050683C>T	ENST00000368994.2	+	7	818	c.567C>T	c.(565-567)atC>atT	p.I189I	BTBD16_ENST00000260723.4_Silent_p.I188I			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	188	BTB.									breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CCGCCCACATCCTCCAGTTCA	0.577000													32	86					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181764162	181764162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181764162C>T	ENST00000526775.1	+	44	6169	c.6004C>T	c.(6004-6006)Cgc>Tgc	p.R2002C	CACNA1E_ENST00000367567.4_Missense_Mutation_p.R1628C|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1953C|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R2021C|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R2045C|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R2064C|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R2015C	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2064					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GTCAGCCCACCGCCTGAACTC	0.547000													12	35					0	0	1	0	0
TEPP	374739	broad.mit.edu	37	16	58019364	58019364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58019364C>T	ENST00000290871.5	+	6	784	c.747C>T	c.(745-747)ccC>ccT	p.P249P	TEPP_ENST00000569996.1_Intron|TEPP_ENST00000441824.2_Intron	NM_199046.2	NP_950247.2	Q6URK8	TEPP_HUMAN	testis, prostate and placenta expressed	229						extracellular region				central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	8						CACCGCGCCCCTATCCCTGCT	0.672000													19	35					0	0	1	0	0
TMEM44	93109	broad.mit.edu	37	3	194344019	194344019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:194344019G>A	ENST00000392432.2	-	5	751	c.546C>T	c.(544-546)ggC>ggT	p.G182G	TMEM44_ENST00000273580.7_Silent_p.G182G|TMEM44_ENST00000330115.3_Silent_p.G79G|TMEM44_ENST00000473092.1_Silent_p.G182G|TMEM44_ENST00000381975.3_Silent_p.G182G|TMEM44_ENST00000347147.4_Silent_p.G182G	NM_001166305.1	NP_001159777.1	Q2T9K0	TMM44_HUMAN	transmembrane protein 44	182						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|urinary_tract(1)	8	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		CCAGCAGGTAGCCGAGGATCT	0.577000													7	9					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5322321	5322321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5322321G>A	ENST00000380224.1	-	1	905	c.856C>T	c.(856-858)Cct>Tct	p.P286S	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAAATGATAGGATTCACGAAT	0.428000													13	69					0	0	1	0	0
SHOX2	6474	broad.mit.edu	37	3	157817725	157817725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:157817725C>T	ENST00000490689.2	-	4	1772	c.239G>A	c.(238-240)gGg>gAg	p.G80E	SHOX2_ENST00000441443.2_Missense_Mutation_p.G80E|SHOX2_ENST00000425436.3_Missense_Mutation_p.G209E|SHOX2_ENST00000389589.4_Missense_Mutation_p.G233E|SHOX2_ENST00000483851.2_Missense_Mutation_p.G209E			O60902	SHOX2_HUMAN	short stature homeobox 2	209	Poly-Gly.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(10)|skin(3)|upper_aerodigestive_tract(1)	20			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GCTGGCGGCCCCTATGAGAAC	0.438000													10	43					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76744366	76744366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76744366G>A	ENST00000369963.3	-	2	395	c.206C>T	c.(205-207)tCc>tTc	p.S69F	IMPG1_ENST00000369950.3_Missense_Mutation_p.S147F			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	147					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GTGCTCCTGGGAATTGCTGAA	0.527000													35	56					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152782813	152782813	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152782813G>A	ENST00000367255.5	-	21	2914	c.2313C>T	c.(2311-2313)caC>caT	p.H771H	SYNE1_ENST00000495090.2_Silent_p.H338H|SYNE1_ENST00000341594.5_Silent_p.H778H|SYNE1_ENST00000367248.3_Silent_p.H761H|SYNE1_ENST00000423061.1_Silent_p.H778H|SYNE1_ENST00000448038.1_Silent_p.H778H|SYNE1_ENST00000265368.4_Silent_p.H771H|SYNE1_ENST00000413186.2_Silent_p.H771H|SYNE1_ENST00000367253.4_Silent_p.H771H	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	771					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGTAATGAGGTGTGCTGTCT	0.413000										HNSCC(10;0.0054)			46	61					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201355491	201355491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201355491G>A	ENST00000391967.2	-	3	1299	c.998C>T	c.(997-999)gCc>gTc	p.A333V	LAD1_ENST00000367313.3_Missense_Mutation_p.A347V	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	333						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						GAGGCGGGAGGCCACAGTCGG	0.667000													4	10					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360233	27360233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27360233C>T	ENST00000335524.3	-	3	1490	c.965G>A	c.(964-966)gGg>gAg	p.G322E		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	322										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCCTGAGGCCCTGCTTCCTT	0.672000													22	69					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52946817	52946817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52946817C>T	ENST00000267119.5	-	1	114	c.45G>A	c.(43-45)ggG>ggA	p.G15G		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	15	Gly-rich.|Head.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CACTGAAGCCCCCCTTGGCGG	0.617000													40	98					0	0	1	0	0
RBM14	10432	broad.mit.edu	37	11	66392364	66392364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66392364C>T	ENST00000310137.4	+	2	1156	c.1017C>T	c.(1015-1017)gcC>gcT	p.A339A	RBM4_ENST00000514361.3_Intron|RBM14-RBM4_ENST00000500635.2_Intron|RBM14-RBM4_ENST00000412278.2_Intron|RBM14_ENST00000409738.4_Intron|RBM4_ENST00000503028.2_Intron|RBM14_ENST00000393979.3_Intron	NM_006328.3	NP_006319.1	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	339	Ala-rich.|TRBP-interacting domain.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						CCTCCCTTGCCTCCTATGGTA	0.612000													36	90					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125403600	125403600	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:125403600G>A	ENST00000359704.2	+	8	1023	c.685G>A	c.(685-687)Gaa>Aaa	p.E229K	RNF217_ENST00000521654.2_Intron|RNF217_ENST00000275184.6_Intron|RNF217_ENST00000560949.1_Intron|RNF217_ENST00000368414.2_Intron	NM_152553.2	NP_689766.1	Q8TC41	RN217_HUMAN	ring finger protein 217	229					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		tacagttgaggaaattaagac	0.353000													6	9					0	0	1	0	0
IDE	3416	broad.mit.edu	37	10	94297234	94297234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:94297234G>A	ENST00000265986.6	-	2	228	c.172C>T	c.(172-174)Cct>Tct	p.P58S		NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	58					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTCTTCAGGAGACTTGGTA	0.388000													10	135					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640458	34640458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34640458C>T	ENST00000537011.1	+	3	771	c.389C>T	c.(388-390)tCt>tTt	p.S130F	NUTM1_ENST00000438749.3_Missense_Mutation_p.S120F|NUTM1_ENST00000333756.4_Missense_Mutation_p.S102F					NUT midline carcinoma, family member 1																		GCTGAGCCCTCTCAAACTCAG	0.577000													40	66					0	0	1	0	0
PTGER2	5732	broad.mit.edu	37	14	52781635	52781635	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52781635G>A	ENST00000245457.5	+	1	523	c.369G>A	c.(367-369)acG>acA	p.T123T	PTGER2_ENST00000557436.1_Intron	NM_000956.3	NP_000947.2	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	123						integral to plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	GCCTGGCCACGATGCTCATGC	0.677000													29	84					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11117651	11117651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:11117651G>A	ENST00000304623.8	-	13	2377	c.2188C>T	c.(2188-2190)Cgc>Tgc	p.R730C	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Missense_Mutation_p.R297C|CTNND2_ENST00000511377.1_Missense_Mutation_p.R639C|CTNND2_ENST00000503622.1_Missense_Mutation_p.R393C|CTNND2_ENST00000359640.2_Missense_Mutation_p.R730C	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	730					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						ATCCTTCTGCGGGCCTCCTCT	0.542000													34	77					0	0	1	0	0
FAM131A	131408	broad.mit.edu	37	3	184062315	184062315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184062315C>T	ENST00000310585.4	+	3	1929	c.565C>T	c.(565-567)Ctc>Ttc	p.L189F	EIF2B5_ENST00000444495.1_Intron|FAM131A_ENST00000383847.2_Missense_Mutation_p.L220F|FAM131A_ENST00000418281.1_Missense_Mutation_p.L97F|FAM131A_ENST00000340957.5_Missense_Mutation_p.L135F|FAM131A_ENST00000453072.1_Missense_Mutation_p.L135F|FAM131A_ENST00000450976.1_Missense_Mutation_p.L135F			Q6UXB0	F131A_HUMAN	family with sequence similarity 131, member A	189						extracellular region				breast(1)|endometrium(1)|large_intestine(2)|lung(9)|skin(1)	14	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGGGCCGCACCTCCAGGACCT	0.632000													9	130					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55655605	55655605	+	Missense_Mutation	SNP	G	G	A	rs146327492		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55655605G>A	ENST00000449290.2	+	4	697	c.605G>A	c.(604-606)cGa>cAa	p.R202Q	TRIM51_ENST00000244891.3_Missense_Mutation_p.R59Q	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	202						intracellular	zinc ion binding										GAAAGGCTGCGAAAGGAGGGC	0.428000													20	80					0	0	1	0	0
LGI3	203190	broad.mit.edu	37	8	22006032	22006032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22006032G>A	ENST00000306317.2	-	8	1577	c.1288C>T	c.(1288-1290)Cgt>Tgt	p.R430C	LGI3_ENST00000424267.2_Missense_Mutation_p.R406C	NM_139278.2	NP_644807.1	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	430					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome		p.R430G(1)		endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	17				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CGGCCGGCACGAAAGTGTTTC	0.632000													11	24					0	0	1	0	0
CDKL2	8999	broad.mit.edu	37	4	76530724	76530724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76530724G>A	ENST00000429927.2	-	5	1340	c.637C>T	c.(637-639)Cat>Tat	p.H213Y	CDKL2_ENST00000307465.4_Missense_Mutation_p.H213Y	NM_003948.3	NP_003939.1	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2 (CDC2-related kinase)	213	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(2)|stomach(2)	22			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ATCATAATATGATATAGCTGA	0.368000													5	68					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212685	26212685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:26212685C>T	ENST00000379034.1	+	2	871	c.722C>T	c.(721-723)tCc>tTc	p.S241F		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	241	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						AACAGAACCTCCCAACATTTG	0.498000													33	14					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127484521	127484521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127484521C>T	ENST00000262461.2	+	12	2146	c.1957C>T	c.(1957-1959)Cgt>Tgt	p.R653C	SLC12A2_ENST00000343225.4_Missense_Mutation_p.R653C	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	653					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGAACCTCTTCGTGGCTACAT	0.323000													53	139					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75174037	75174037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:75174037G>A	ENST00000336926.6	-	27	2748	c.2722C>T	c.(2722-2724)Cat>Tat	p.H908Y	HIP1_ENST00000434438.2_Missense_Mutation_p.H857Y	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	908	I/LWEQ.|Important for actin binding (By similarity).				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCAATTTCATGAGAACACACC	0.527000			T	PDGFRB	CMML								15	44					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113283288	113283288	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113283288G>A	ENST00000362072.3	-	7	1472	c.1128C>T	c.(1126-1128)gcC>gcT	p.A376A	DRD2_ENST00000544518.1_Silent_p.A375A|DRD2_ENST00000542968.1_Silent_p.A376A|DRD2_ENST00000346454.3_Silent_p.A347A|DRD2_ENST00000538967.1_Silent_p.A378A|DRD2_ENST00000355319.2_Silent_p.A378A	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	376					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CGAGAACAATGGCGAGCATCT	0.582000													14	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9062500	9062500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9062500C>T	ENST00000397910.4	-	3	25149	c.24946G>A	c.(24946-24948)Gaa>Aaa	p.E8316K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8318	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTCCAGGTTCTCTGCTTATG	0.488000													43	88					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34158556	34158556	+	Silent	SNP	G	G	A	rs142510996		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34158556G>A	ENST00000373381.4	-	25	4202	c.4026C>T	c.(4024-4026)atC>atT	p.I1342I	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Silent_p.I215I	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1302	CUB 8.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTCTGCTTCGATGGTCCAGA	0.567000													19	175					0	0	1	0	0
RASGRP1	10125	broad.mit.edu	37	15	38803830	38803830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:38803830G>A	ENST00000310803.5	-	8	1118	c.941C>T	c.(940-942)tCg>tTg	p.S314L	RASGRP1_ENST00000559830.1_Missense_Mutation_p.S314L|RASGRP1_ENST00000539159.1_Missense_Mutation_p.S266L|RASGRP1_ENST00000450598.2_Missense_Mutation_p.S314L|RASGRP1_ENST00000561180.1_Missense_Mutation_p.S365L|RASGRP1_ENST00000558164.1_Missense_Mutation_p.S314L	NM_001128602.1|NM_005739.3	NP_001122074.1|NP_005730.2	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	314	Ras-GEF.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding	p.S314L(2)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TGGGACATGCGAACTTGTCTC	0.493000													9	80					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76569600	76569600	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:76569600G>A	ENST00000307431.8	+	19	3296	c.2911G>A	c.(2911-2913)Gga>Aga	p.G971R	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.G923R|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.G975R|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.G899R	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	972	EGF-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						ATGCCGCAATGGAGGGAAATG	0.502000													13	30					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087697	9087697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9087697G>A	ENST00000397910.4	-	1	4321	c.4118C>T	c.(4117-4119)tCa>tTa	p.S1373L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1373	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGATTGGGTGAACTTGAGAT	0.468000													36	72					0	0	1	0	0
ENPP5	59084	broad.mit.edu	37	6	46133190	46133190	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46133190G>A	ENST00000371383.2	-	4	1200	c.940C>T	c.(940-942)Caa>Taa	p.Q314*	ENPP5_ENST00000492313.1_5'UTR|ENPP5_ENST00000230565.3_Nonsense_Mutation_p.Q314*			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	314						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						ATGATTGGTTGAATTCGACTG	0.383000													69	145					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77378026	77378026	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77378026C>T	ENST00000451710.3	-	26	3798	c.3561G>A	c.(3559-3561)ctG>ctA	p.L1187L	TRPM6_ENST00000376864.4_Silent_p.L1187L|TRPM6_ENST00000449912.2_Silent_p.L1182L|TRPM6_ENST00000360774.1_Silent_p.L1187L|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Silent_p.L1182L|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1187					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TCATTTCTTTCAGCTGGAAGT	0.463000													9	45					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55705875	55705875	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55705875C>T	ENST00000379906.2	+	3	687	c.432C>T	c.(430-432)atC>atT	p.I144I	SLC6A2_ENST00000566163.1_Silent_p.I144I|SLC6A2_ENST00000414754.3_Silent_p.I144I|SLC6A2_ENST00000561820.1_Silent_p.I144I|SLC6A2_ENST00000568943.1_Silent_p.I144I|SLC6A2_ENST00000219833.8_Silent_p.I144I|SLC6A2_ENST00000567238.1_Silent_p.I39I	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	144					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TCATCCTGATCGCCCTGTACG	0.607000													15	37					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60696263	60696263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60696263C>T	ENST00000005286.4	+	4	850	c.697C>T	c.(697-699)Cca>Tca	p.P233S	TMEM132A_ENST00000453848.2_Missense_Mutation_p.P233S	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	233						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GCAGGCCCTCCCAGTGGGGGG	0.701000													11	22					0	0	1	0	0
RFWD3	55159	broad.mit.edu	37	16	74662525	74662525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:74662525G>A	ENST00000361070.4	-	11	1891	c.1794C>T	c.(1792-1794)gcC>gcT	p.A598A	RFWD3_ENST00000571750.1_Silent_p.A598A	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	598					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						ATGCAGCTGAGGCAGCTCTGG	0.517000													56	152					0	0	1	0	0
ACAP3	116983	broad.mit.edu	37	1	1229502	1229502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1229502G>A	ENST00000354700.5	-	22	2419	c.2217C>T	c.(2215-2217)ccC>ccT	p.P739P	ACAP3_ENST00000353662.3_Silent_p.P664P	NM_030649.2	NP_085152.2	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	739					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			endometrium(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	14						CGTGGTGCAGGGGCGCCCGGC	0.711000													3	5					0	0	1	0	0
TRAF2	7186	broad.mit.edu	37	9	139815662	139815662	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139815662C>T	ENST00000359662.3	+	9	1334	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F	TRAF2_ENST00000536468.1_Missense_Mutation_p.S378F|TRAF2_ENST00000247668.2_Missense_Mutation_p.S378F			Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	378	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		GCCATCTTCTCCCCAGGTGTG	0.597000													16	41					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111551725	111551725	+	Missense_Mutation	SNP	G	G	A	rs150003283	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:111551725G>A	ENST00000389811.4	+	5	543	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K	ACOXL_ENST00000439055.1_Missense_Mutation_p.E107K|ACOXL_ENST00000340561.4_Missense_Mutation_p.E107K			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	107					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						GATCCAGACCGAAGCCACCTT	0.537000													14	62					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27321384	27321384	+	Silent	SNP	G	G	A	rs148009259		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27321384G>A	ENST00000407991.1	-	6	1184	c.576C>T	c.(574-576)ttC>ttT	p.F192F	CHRNA2_ENST00000520933.2_Silent_p.F192F|CHRNA2_ENST00000240132.2_Silent_p.F177F	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	192						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	TCTGCTGGTCGAAGGGGAAGA	0.567000													47	92					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23235850	23235850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23235850C>T	ENST00000285848.5	+	1	120	c.120C>T	c.(118-120)ttC>ttT	p.F40F		NM_005015.3	NP_005006.3	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	0					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding	p.F40F(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		AAAAGTGCTTCCTCTCGAGGG	0.547000													69	148					0	0	1	0	0
DYNAP	284254	broad.mit.edu	37	18	52262188	52262188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52262188G>A	ENST00000321600.1	+	2	200	c.154G>A	c.(154-156)Gac>Aac	p.D52N	DYNAP_ENST00000585973.1_Intron	NM_173629.1	NP_775900.1			dynactin associated protein																		ACATCCAAATGACCAAGAGGC	0.433000													37	71					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127638767	127638767	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127638767C>T	ENST00000508053.1	-	52	6789	c.5815G>A	c.(5815-5817)Gag>Aag	p.E1939K	FBN2_ENST00000262464.4_Missense_Mutation_p.E1939K			P35556	FBN2_HUMAN	fibrillin 2	1939	EGF-like 32; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGATGCCGCTCGCACTCATCA	0.348000													27	96					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179648883	179648883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179648883C>T	ENST00000589042.1	-	16	2913	c.2689G>A	c.(2689-2691)Gag>Aag	p.E897K	TTN_ENST00000342992.6_Missense_Mutation_p.E897K|TTN_ENST00000360870.5_Missense_Mutation_p.E897K|TTN_ENST00000460472.2_Missense_Mutation_p.E851K|TTN_ENST00000342175.6_Missense_Mutation_p.E851K|TTN_ENST00000359218.5_Missense_Mutation_p.E851K|TTN_ENST00000591111.1_Missense_Mutation_p.E897K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	897							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTCACCTCAACGCCAGCT	0.547000													37	91					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91827259	91827259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91827259G>A	ENST00000394232.1	+	11	1986	c.1516G>A	c.(1516-1518)Gag>Aag	p.E506K	SV2B_ENST00000330276.4_Missense_Mutation_p.E506K|SV2B_ENST00000545111.2_Missense_Mutation_p.E355K	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	506					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			AGACCTCTACGAGCACAAGTT	0.512000													34	334					0	0	1	0	0
ZNF71	58491	broad.mit.edu	37	19	57133340	57133340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57133340C>T	ENST00000328070.6	+	3	919	c.685C>T	c.(685-687)Ctc>Ttc	p.L229F		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	229						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GACTTCCTCTCTCACCCAGCA	0.642000													19	55					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110826298	110826298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110826298C>T	ENST00000375820.4	-	40	3575	c.3454G>A	c.(3454-3456)Gag>Aag	p.E1152K		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1152	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTGCCTGGCTCCCCTTTCTGG	0.587000													15	43					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059450	9059450	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9059450G>A	ENST00000397910.4	-	3	28199	c.27996C>T	c.(27994-27996)tcC>tcT	p.S9332S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9334	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCCTGGGATGGATGTTCTGC	0.498000													37	130					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234851403	234851403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234851403G>A	ENST00000355722.4	+	5	674	c.560G>A	c.(559-561)gGa>gAa	p.G187E	TRPM8_ENST00000324695.4_Intron|TRPM8_ENST00000433712.2_Intron|TRPM8_ENST00000409625.1_Missense_Mutation_p.G160E			Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	0	Epitope; activates specific cytotoxic T lymphocytes.					integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTACCGGTGGGACAGGAGGAG	0.572000													20	56					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116930446	116930446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116930446C>T	ENST00000356083.3	+	3	1002	c.611C>T	c.(610-612)cCg>cTg	p.P204L		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	204	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						AAGATGAACCCGCATGCAGTC	0.597000													20	51					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24440779	24440779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:24440779G>A	ENST00000383168.4	-	4	778	c.650C>T	c.(649-651)tCc>tTc	p.S217F	AQP4_ENST00000581374.1_Missense_Mutation_p.S195F|AQP4_ENST00000440832.3_Missense_Mutation_p.S195F|AQP4-AS1_ENST00000582605.1_RNA|AQP4_ENST00000583022.1_5'UTR|AQP4-AS1_ENST00000579964.1_RNA	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	217					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					AGGTCCAAAGGATCGGGCGGG	0.433000													11	197					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95748146	95748146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:95748146G>A	ENST00000311106.3	-	7	995	c.758C>T	c.(757-759)tCa>tTa	p.S253L	PCSK1_ENST00000508626.1_Missense_Mutation_p.S206L|PCSK1_ENST00000513085.1_5'UTR|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	253	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAATCCAATTGAACTGGCCTC	0.468000													20	56					0	0	1	0	0
SSBP2	23635	broad.mit.edu	37	5	80769541	80769541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:80769541C>T	ENST00000320672.4	-	8	758	c.548G>A	c.(547-549)gGa>gAa	p.G183E	SSBP2_ENST00000515395.1_Missense_Mutation_p.G153E|SSBP2_ENST00000514493.1_Missense_Mutation_p.G153E|SSBP2_ENST00000509053.1_Missense_Mutation_p.G153E|SSBP2_ENST00000505980.1_Missense_Mutation_p.G163E	NM_001256732.1|NM_001256733.1|NM_012446.3	NP_001243661.1|NP_001243662.1|NP_036578.2	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	183	Gly-rich.|Pro-rich.			MTPPRGMVPLGP -> NDSSKRNGCLRTTVLTPGLSL (in Ref. 2; AAD27781).	regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		GGGCACCATTCCTCTTGGAGG	0.403000													19	45					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1079966	1079966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1079966G>A	ENST00000313093.2	+	13	1783	c.1552G>A	c.(1552-1554)Gcg>Acg	p.A518T	HMHA1_ENST00000543365.1_Missense_Mutation_p.A401T|HMHA1_ENST00000539243.2_Missense_Mutation_p.A534T|HMHA1_ENST00000586866.1_Missense_Mutation_p.A522T|HMHA1_ENST00000590577.1_Missense_Mutation_p.A153T|HMHA1_ENST00000590214.1_Missense_Mutation_p.A545T|HMHA1_ENST00000536472.1_Missense_Mutation_p.A358T	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	518					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TATGCAGACGGCGCCGCTGCC	0.672000													52	105					0	0	1	0	0
CLEC6A	93978	broad.mit.edu	37	12	8610502	8610502	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8610502G>A	ENST00000382073.3	+	2	226	c.40G>A	c.(40-42)Ggc>Agc	p.G14S		NM_001007033.1	NP_001007034.1	Q6EIG7	CLC6A_HUMAN	C-type lectin domain family 6, member A	14					defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)|large_intestine(2)|lung(7)	10	Lung SC(5;0.184)					AGAGAAAAGAGGCTGGTTGTC	0.483000													16	51					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469404	72469404	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:72469404G>A	ENST00000296776.5	+	1	383	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	112						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		CCCGGACTCGGAACAGACACC	0.517000													37	77					0	0	1	0	0
MTX1	4580	broad.mit.edu	37	1	155178747	155178747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155178747G>A	ENST00000368376.3	+	1	258	c.152G>A	c.(151-153)gGg>gAg	p.G51E	MTX1_ENST00000316721.4_Missense_Mutation_p.G51E	NM_002455.3	NP_002446.2	Q13505	MTX1_HUMAN	metaxin 1	51					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCGCCTTCAGGGGTTCGGGGC	0.721000													8	12					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90897947	90897947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90897947C>T	ENST00000354377.3	+	2	241	c.55C>T	c.(55-57)Cct>Tct	p.P19S	ZNF774_ENST00000379090.5_Missense_Mutation_p.P19S|ZNF774_ENST00000558115.1_Intron	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	19	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CTTAGAGAATCCTCTCCAGGA	0.438000													12	26					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117788850	117788850	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117788850G>A	ENST00000350763.4	-	26	6705	c.6294C>T	c.(6292-6294)cgC>cgT	p.R2098R	TNC_ENST00000341037.4_Silent_p.R1916R|TNC_ENST00000542877.1_Silent_p.R1735R|TNC_ENST00000340094.3_Silent_p.R1734R|TNC_ENST00000537320.1_Silent_p.R1461R|TNC_ENST00000535648.1_Silent_p.R1643R|TNC_ENST00000423613.2_Silent_p.R1825R|TNC_ENST00000345230.3_Silent_p.R1461R|TNC_ENST00000346706.3_Silent_p.R1552R	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2098	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TCAGCTTGTAGCGAGTCTTGG	0.562000													17	50					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113999705	113999705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113999705G>A	ENST00000429538.3	-	6	675	c.481C>T	c.(481-483)Ccc>Tcc	p.P161S	AC016683.6_ENST00000333145.5_RNA|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000263335.7_Missense_Mutation_p.P161S|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000451179.1_RNA|PAX8_ENST00000397647.3_Missense_Mutation_p.P161S|PAX8_ENST00000348715.5_Missense_Mutation_p.P161S|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000422956.1_RNA|PAX8_ENST00000263334.5_Missense_Mutation_p.P161S	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	161					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity	p.P161S(1)	PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						GCTGAGCTGGGGACTGCAGTG	0.642000			T	PPARG	follicular thyroid		Thyroid dysgenesis						13	15					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71575494	71575494	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:71575494C>T	ENST00000304743.2	+	34	6921	c.6475C>T	c.(6475-6477)Cga>Tga	p.R2159*	PCNX_ENST00000238570.5_Nonsense_Mutation_p.R2087*|PCNX_ENST00000556272.1_3'UTR|PCNX_ENST00000439984.3_Nonsense_Mutation_p.R2048*	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	2159	Ser-rich.					integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GATATCGCTTCGAAACTTGCC	0.562000													10	65					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167689675	167689675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167689675G>A	ENST00000519204.1	+	28	7940	c.7822G>A	c.(7822-7824)Gag>Aag	p.E2608K	TENM2_ENST00000403607.2_Missense_Mutation_p.E2553K|TENM2_ENST00000545108.1_Missense_Mutation_p.E2728K|TENM2_ENST00000518659.1_Missense_Mutation_p.E2729K|TENM2_ENST00000520394.1_Missense_Mutation_p.E2490K					teneurin transmembrane protein 2																		GACTGAGGGCGAGAAGCAGCA	0.642000													4	13					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551092	248551092	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248551092C>T	ENST00000355728.2	+	1	183	c.183C>T	c.(181-183)ttC>ttT	p.F61F		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCATGTACTTCCTCCTCAGCC	0.488000													17	87					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52473641	52473641	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:52473641C>T	ENST00000219746.9	-	7	1511	c.1227G>A	c.(1225-1227)tcG>tcA	p.S409S	TOX3_ENST00000407228.3_Silent_p.S404S	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	409					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						CCCCAATGTTCGAGGGCATGT	0.542000													50	114					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395100	49395100	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49395100G>A	ENST00000419783.1	-	2	654	c.333C>T	c.(331-333)ctC>ctT	p.L111L	GPX1_ENST00000419349.1_3'UTR|GPX1_ENST00000496791.1_5'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	111					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	ACTTCTCGAAGAGCATGAAGT	0.617000													14	87					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113943595	113943595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113943595C>T	ENST00000245796.6	+	5	1586	c.1391C>T	c.(1390-1392)tCg>tTg	p.S464L	PSD4_ENST00000441564.2_Missense_Mutation_p.S436L	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	464					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCCCTGCATCGTCCCAGGAG	0.617000													14	38					0	0	1	0	0
C18orf25	147339	broad.mit.edu	37	18	43796276	43796276	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43796276C>T	ENST00000282059.6	+	2	804	c.430C>T	c.(430-432)Cga>Tga	p.R144*	C18orf25_ENST00000321319.6_Nonsense_Mutation_p.R144*	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	144										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						TAGGCGGTCCCGATCTGAAAG	0.532000													7	100					0	0	1	0	0
ING4	51147	broad.mit.edu	37	12	6761495	6761495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6761495G>A	ENST00000341550.4	-	6	633	c.587C>T	c.(586-588)aCc>aTc	p.T196I	ING4_ENST00000423703.2_Intron|ING4_ENST00000444704.2_Missense_Mutation_p.T173I|ING4_ENST00000486287.1_Intron|ING4_ENST00000412586.2_Missense_Mutation_p.T194I|ING4_ENST00000446105.2_Missense_Mutation_p.T193I|ING4_ENST00000396807.4_Missense_Mutation_p.T197I			Q9UNL4	ING4_HUMAN	inhibitor of growth family, member 4	197					apoptosis|cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell proliferation|negative regulation of growth|negative regulation of transcription, DNA-dependent|positive regulation of apoptosis	histone acetyltransferase complex	protein binding|transcription coactivator activity|zinc ion binding			central_nervous_system(3)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)	10						AAGGCAATAGGTGGGTTCGTT	0.522000													35	99					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91404608	91404608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:91404608G>A	ENST00000370440.1	-	3	2520	c.2303C>T	c.(2302-2304)tCa>tTa	p.S768L	ZNF644_ENST00000467231.1_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.S768L|ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000347275.5_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	768					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGAATTTAATGAACTAGCTTC	0.328000													49	78					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37505206	37505206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37505206G>A	ENST00000374660.1	+	38	3255	c.3156G>A	c.(3154-3156)atG>atA	p.M1052I	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.M933I|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.M933I			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1055						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CAGGAAAAATGGAACAAATGA	0.333000													23	69					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380880	56380880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56380880C>T	ENST00000526538.1	-	1	98	c.99G>A	c.(97-99)gcG>gcA	p.A33A		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						TTAGGTAGATCGCAAGGAATA	0.493000													48	76					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206869639	206869639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206869639G>A	ENST00000403263.1	-	11	2941	c.2537C>T	c.(2536-2538)cCc>cTc	p.P846L		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	846					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						TGTTGTGTGGGGAGAGGTGAT	0.517000													13	128					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31536324	31536324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31536324C>T	ENST00000215885.3	-	1	269	c.17G>A	c.(16-18)gGg>gAg	p.G6E		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	6					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						CCCAAACAGCCCTGCCTGAAC	0.677000													28	68					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149361299	149361299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149361299G>A	ENST00000286298.4	+	3	2411	c.2143G>A	c.(2143-2145)Gcg>Acg	p.A715T		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	715	STAS.		A -> V (in AO2).			integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGTGTATGAAGCGATGGCTTT	0.403000													19	94					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93148206	93148206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93148206C>T	ENST00000298050.3	+	13	1664	c.1564C>T	c.(1564-1566)Ccc>Tcc	p.P522S	CCDC67_ENST00000525646.1_Missense_Mutation_p.P264S	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	522										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TACAATGCCTCCCTTGCCACC	0.408000													19	81					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39224440	39224440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39224440C>T	ENST00000333039.2	-	2	825	c.702G>A	c.(700-702)aaG>aaA	p.K234K		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	234						integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					GCTGGTCCATCTTGGAGTGTA	0.657000													8	19					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7830562	7830562	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7830562G>A	ENST00000327325.5	+	4	371	c.253G>A	c.(253-255)Gag>Aag	p.E85K	CLEC4M_ENST00000248228.4_Missense_Mutation_p.E85K|CLEC4M_ENST00000595496.1_Missense_Mutation_p.E64K|CLEC4M_ENST00000596707.1_Missense_Mutation_p.E64K|CLEC4M_ENST00000334806.5_Missense_Mutation_p.E57K|CLEC4M_ENST00000596363.1_Missense_Mutation_p.E57K|CLEC4M_ENST00000597522.1_Missense_Mutation_p.E85K|CLEC4M_ENST00000357361.2_Missense_Mutation_p.E85K|CLEC4M_ENST00000394122.2_Missense_Mutation_p.E73K|CLEC4M_ENST00000359059.5_Missense_Mutation_p.E64K	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	85					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						GGAACAATCCGAGCAAGACGC	0.512000													37	100					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132010506	132010506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132010506G>A	ENST00000356920.5	+	13	1706	c.1612G>A	c.(1612-1614)Gct>Act	p.A538T	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	538							ATP binding										AAATTTTATGGCTATCGAAGA	0.353000													9	145					0	0	1	0	0
MS4A6A	64231	broad.mit.edu	37	11	59940507	59940507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59940507G>A	ENST00000528851.1	-	6	785	c.645C>T	c.(643-645)ttC>ttT	p.F215F	MS4A6A_ENST00000323961.3_Silent_p.F215F|MS4A6A_ENST00000530839.1_Silent_p.F215F|MS4A6A_ENST00000420732.2_3'UTR|MS4A6A_ENST00000533023.1_3'UTR|MS4A6A_ENST00000529054.1_Silent_p.F243F|MS4A6A_ENST00000412309.2_Silent_p.F243F|MS4A6A_ENST00000426738.2_Silent_p.F170F			Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member 6A	215						integral to membrane	receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCACCCCAGGGAAGTCAGAGT	0.507000													31	165					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156747679	156747679	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156747679C>T	ENST00000347377.6	+	15	1971	c.1540C>T	c.(1540-1542)Cga>Tga	p.R514*	CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Nonsense_Mutation_p.R188*|CYFIP2_ENST00000377576.3_Nonsense_Mutation_p.R514*|CYFIP2_ENST00000318218.6_Nonsense_Mutation_p.R514*|CYFIP2_ENST00000541131.1_Nonsense_Mutation_p.R439*|CYFIP2_ENST00000522463.1_Nonsense_Mutation_p.R318*|CYFIP2_ENST00000521420.1_Nonsense_Mutation_p.R488*	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	514					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACAGGCAATTCGAAAGACCAT	0.532000													24	46					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101348054	101348054	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101348054C>T	ENST00000534062.1	-	1	3130	c.3072G>A	c.(3070-3072)agG>agA	p.R1024R		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	1024										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TCGATGGATCCCTGGGGAATC	0.577000													3	11					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76437211	76437211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76437211C>T	ENST00000389840.5	-	72	11681	c.11557G>A	c.(11557-11559)Gag>Aag	p.E3853K	DNAH17_ENST00000585328.1_Missense_Mutation_p.E3862K|DNAH17_ENST00000586052.1_Intron					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CTGCTCTCCTCGTAGGACTTA	0.557000													16	29					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182517	100182517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100182517C>T	ENST00000554176.1	+	4	1095	c.429C>T	c.(427-429)ttC>ttT	p.F143F	CYP46A1_ENST00000261835.3_Silent_p.F296F|CYP46A1_ENST00000423126.2_Silent_p.F199F			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	296					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				TGGACAACTTCGTCACCTTCT	0.542000													32	63					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872281	51872281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51872281G>A	ENST00000371497.5	+	2	3171	c.2284G>A	c.(2284-2286)Gat>Aat	p.D762N	TSHZ2_ENST00000329613.6_Missense_Mutation_p.D759N|TSHZ2_ENST00000603338.2_Missense_Mutation_p.D759N	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	762					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TGAGAACAGCGATCAGCCCAT	0.532000													12	95					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883384	228883384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228883384C>T	ENST00000392056.3	-	7	2232	c.2186G>A	c.(2185-2187)cGg>cAg	p.R729Q	SPHKAP_ENST00000344657.5_Missense_Mutation_p.R729Q	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	729						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCACCAAGCCGTACAATATG	0.453000													39	123					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23809268	23809268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23809268C>T	ENST00000354639.3	+	13	2001	c.1537C>T	c.(1537-1539)Cta>Tta	p.L513L	STK31_ENST00000433467.2_Silent_p.L536L|STK31_ENST00000355870.3_Silent_p.L536L|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Silent_p.L513L	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	536							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GGTTTTTGACCTATCTGTGGA	0.363000													10	184					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24511603	24511603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:24511603G>A	ENST00000264463.4	-	6	1342	c.835C>T	c.(835-837)Ctt>Ttt	p.L279F		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	279	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GAGGATTCAAGAACTCGAAGA	0.423000										HNSCC(23;0.051)			10	44					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735076	55735076	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55735076G>A	ENST00000312345.2	-	1	914	c.864C>T	c.(862-864)atC>atT	p.I288I		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					ATGCCACCATGATATCTTTGT	0.333000													12	54					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794954	126794954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126794954C>T	ENST00000373615.4	+	5	1928	c.1189C>T	c.(1189-1191)Ccc>Tcc	p.P397S		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	397				GHEPHSPSQTTLTNLF -> AMSLTAPHKRLLPTFSNDSQP PHPTISLKKKLSLV (in Ref. 1; AAB08752).		nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						GCCTCACAGCCCCTCACAAAC	0.493000													23	61					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40913356	40913356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40913356C>T	ENST00000346991.5	+	11	1362	c.972C>T	c.(970-972)tcC>tcT	p.S324S	CASC5_ENST00000399668.2_Silent_p.S298S|CASC5_ENST00000527044.1_3'UTR			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	324	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TTCCCACATCCAGTGAGACCA	0.363000													19	64					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227983445	227983445	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227983445T>C	ENST00000396625.3	-	7	612	c.405A>G	c.(403-405)aaA>aaG	p.K135K	COL4A4_ENST00000329662.7_Silent_p.K135K	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	135	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCATACCAGGTTTGCCTCTGG	0.493000													29	67					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11204731	11204731	+	Missense_Mutation	SNP	G	G	A	rs17848545	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11204731G>A	ENST00000361445.4	-	34	4922	c.4846C>T	c.(4846-4848)Cgc>Tgc	p.R1616C	MTOR-AS1_ENST00000420480.1_RNA|MTOR_ENST00000495435.1_5'UTR|MTOR-AS1_ENST00000445982.1_RNA	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1616	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CAGATCTGGCGGATGATCTCT	0.582000													20	52					0	0	1	0	0
PLAC9	219348	broad.mit.edu	37	10	81903997	81903997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81903997G>A	ENST00000372263.3	+	3	223	c.181G>A	c.(181-183)Gat>Aat	p.D61N	PLAC9_ENST00000372270.2_Missense_Mutation_p.D19N|PLAC9_ENST00000372267.2_Intron	NM_001012973.1	NP_001012991.1	Q5JTB6	PLAC9_HUMAN	placenta-specific 9	61						extracellular region				kidney(1)|ovary(1)	2	Prostate(51;0.0095)|all_epithelial(25;0.175)		Colorectal(32;0.109)			GAAGACCGTGGATCACCTGGG	0.612000											OREG0020321	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	65					0	0	1	0	0
BPIFA2	140683	broad.mit.edu	37	20	31763243	31763243	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31763243A>G	ENST00000253362.2	+	5	587	c.441A>G	c.(439-441)aaA>aaG	p.K147K	BPIFA2_ENST00000354932.5_Silent_p.K147K			Q96DR5	SPLC2_HUMAN	BPI fold containing family A, member 2	147						extracellular region	lipid binding										TCAACCTGAAAGCCTCCTTGG	0.537000													50	126					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102743580	102743580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102743580G>A	ENST00000210633.3	+	14	2302	c.2224G>A	c.(2224-2226)Gag>Aag	p.E742K	MRPL43_ENST00000299179.5_Intron|RP11-108L7.4_ENST00000447344.1_RNA|MRPL43_ENST00000370242.4_Intron|MRPL43_ENST00000370241.3_Intron|SEMA4G_ENST00000517724.1_Intron|MRPL43_ENST00000318325.2_Intron|MRPL43_ENST00000342071.1_Intron|SEMA4G_ENST00000370250.4_Missense_Mutation_p.E737K			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	737					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		GTGTCCTGGAGAGGAAGATGA	0.672000													5	9					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183586769	183586769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:183586769C>T	ENST00000264065.6	+	5	800	c.385C>T	c.(385-387)Cct>Tct	p.P129S	DNAJC10_ENST00000469118.1_3'UTR|DNAJC10_ENST00000537515.1_Missense_Mutation_p.P129S	NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	129					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGATGATGATCCTGAAATCAT	0.259000													43	98					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32030581	32030581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:32030581G>A	ENST00000360311.4	+	2	559	c.10G>A	c.(10-12)Gag>Aag	p.E4K		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						CATGTTACGTGAGGAAGCAGC	0.453000													29	88					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151115019	151115019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151115019G>A	ENST00000341697.3	-	3	1770	c.79C>T	c.(79-81)Ccc>Tcc	p.P27S				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	27						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGGTCCTGGGGAAAGGCGGCC	0.607000													16	22					0	0	1	0	0
TTYH2	94015	broad.mit.edu	37	17	72249256	72249256	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72249256C>T	ENST00000441391.2	+	6	1545	c.333C>T	c.(331-333)ccC>ccT	p.P111P	TTYH2_ENST00000269346.4_Silent_p.P432P|TTYH2_ENST00000529107.1_Silent_p.P411P	NM_052869.1	NP_443101.1	Q9BSA4	TTYH2_HUMAN	tweety family member 2	432						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						ATGATGACCCCTTTAACCCCC	0.582000													56	193					0	0	1	0	0
YTHDF1	54915	broad.mit.edu	37	20	61834932	61834932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61834932G>A	ENST00000370339.3	-	4	701	c.360C>T	c.(358-360)ttC>ttT	p.F120F	YTHDF1_ENST00000370333.4_Silent_p.F70F|YTHDF1_ENST00000370334.4_Intron	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	120										NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						GGAAAAAATTGAACCTGTGCT	0.542000													23	64					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880804	142880804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142880804C>T	ENST00000446620.1	+	1	293	c.293C>T	c.(292-294)tCa>tTa	p.S98L		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	98					sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.S98*(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					ACCATCAGCTCAACCTCCCTA	0.388000													46	116					0	0	1	0	0
C1orf51	148523	broad.mit.edu	37	1	150259114	150259114	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150259114C>T	ENST00000290363.5	+	5	1355	c.906C>T	c.(904-906)ccC>ccT	p.P302P	C1orf51_ENST00000369094.1_Silent_p.P214P|C1orf51_ENST00000369095.1_Silent_p.P302P	NM_144697.2	NP_653298.1	Q8N365	CA051_HUMAN	chromosome 1 open reading frame 51	302										endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(2)	10	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGTGCAACCCTTCACCCACT	0.557000													17	168					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38958423	38958423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38958423G>A	ENST00000355481.4	+	25	3483	c.3352G>A	c.(3352-3354)Gag>Aag	p.E1118K	RYR1_ENST00000360985.3_Missense_Mutation_p.E1118K|RYR1_ENST00000359596.3_Missense_Mutation_p.E1118K	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1118	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGGAGCTGACGAGCTGGCCTA	0.632000													22	50					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31434475	31434475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31434475G>A	ENST00000389202.2	+	24	2870	c.2821G>A	c.(2821-2823)Gat>Aat	p.D941N		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	941					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TGCAACCTCCGATGAGAAGAA	0.498000													12	47					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242755720	242755720	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242755720C>T	ENST00000391969.2	+	3	750	c.39C>T	c.(37-39)ttC>ttT	p.F13F	NEU4_ENST00000405370.1_Silent_p.F13F|NEU4_ENST00000404257.1_Silent_p.F25F|NEU4_ENST00000325935.6_Silent_p.F26F|NEU4_ENST00000407683.1_Silent_p.F13F	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	13						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CAGTGCTCTTCGAGCGGGAGA	0.697000													9	41					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48625280	48625280	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:48625280C>T	ENST00000297423.4	+	15	2418	c.2034C>T	c.(2032-2034)gtC>gtT	p.V678V	SPIDR_ENST00000518074.1_Silent_p.V618V|SPIDR_ENST00000517693.1_Silent_p.V153V|SPIDR_ENST00000541342.1_Silent_p.V608V|SPIDR_ENST00000521214.1_3'UTR	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		TGACCGATGTCACTCTGCAAA	0.498000													11	111					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390352	8390352	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8390352C>T	ENST00000471889.1	+	5	1184	c.799C>T	c.(799-801)Cga>Tga	p.R267*	SLC45A1_ENST00000377479.2_Nonsense_Mutation_p.R301*|SLC45A1_ENST00000289877.8_Nonsense_Mutation_p.R267*			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	267					carbohydrate transport	integral to membrane	symporter activity	p.R267*(1)		central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGGACAGCTCCGAGTCATTTA	0.637000													39	119					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49654524	49654524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49654524C>T	ENST00000249601.4	-	10	2303	c.2007G>A	c.(2005-2007)agG>agA	p.R669R	ARHGAP22_ENST00000477708.2_Silent_p.R502R|ARHGAP22_ENST00000435790.2_Silent_p.R675R|ARHGAP22_ENST00000374170.1_Silent_p.R510R|ARHGAP22_ENST00000374172.1_Silent_p.R560R|ARHGAP22_ENST00000417247.2_Silent_p.R579R|ARHGAP22_ENST00000417912.2_Silent_p.R685R	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	669					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						ACAGCTGGTTCCTCCTCTCCG	0.512000													47	90					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160094972	160094972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160094972C>T	ENST00000361216.3	+	7	766	c.677C>T	c.(676-678)tCc>tTc	p.S226F	ATP1A2_ENST00000392233.3_Missense_Mutation_p.S226F|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	226					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CAGACCCGCTCCCCCGAGTTC	0.552000													27	53					0	0	1	0	0
LIAS	11019	broad.mit.edu	37	4	39465209	39465209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39465209C>T	ENST00000261434.3	+	4	495	c.377C>T	c.(376-378)gCc>gTc	p.A126V	LIAS_ENST00000515061.1_3'UTR|LIAS_ENST00000513731.1_Intron|LIAS_ENST00000340169.2_Missense_Mutation_p.A126V|LIAS_ENST00000381846.1_Missense_Mutation_p.A126V	NM_006859.2	NP_006850.2	O43766	LIAS_HUMAN	lipoic acid synthetase	126					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)|ovary(2)	12					Lipoic Acid(DB00166)	TATGCCACCGCCACAGCCACG	0.458000													11	34					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54308037	54308037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54308037C>T	ENST00000545554.1	+	1	2937	c.2937C>T	c.(2935-2937)gcC>gcT	p.A979A	UNC13C_ENST00000537900.1_Silent_p.A979A|UNC13C_ENST00000260323.11_Silent_p.A979A			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	979					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CTTTAAGGGCCTATAAAAAGC	0.383000													4	11					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48463602	48463602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48463602G>A	ENST00000358536.4	-	6	1701	c.1432C>T	c.(1432-1434)Cct>Tct	p.P478S	PLXNB1_ENST00000456774.1_Missense_Mutation_p.P478S|PLXNB1_ENST00000296440.6_Missense_Mutation_p.P478S|PLXNB1_ENST00000358459.4_Missense_Mutation_p.P478S|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	478	Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAAGCCACAGGAACCTTCAGA	0.592000													21	33					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15964870	15964870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:15964870G>A	ENST00000268712.3	-	37	5983	c.5726C>T	c.(5725-5727)cCt>cTt	p.P1909L	NCOR1_ENST00000395857.3_Missense_Mutation_p.P493L|NCOR1_ENST00000395851.1_Intron	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1909	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TTTTGGAGGAGGCCCTTTATC	0.463000													22	154					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151123529	151123529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151123529G>A	ENST00000370328.3	-	9	1218	c.1165C>T	c.(1165-1167)Cgt>Tgt	p.R389C	GABRE_ENST00000370325.1_3'UTR|GABRE_ENST00000483564.1_5'UTR	NM_004961.3	NP_004952.2	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	389					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GCACGGGTACGGGCATGGGCA	0.547000													3	6					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531888	92531888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92531888G>A	ENST00000298047.6	+	9	5726	c.5709G>A	c.(5707-5709)ctG>ctA	p.L1903L	FAT3_ENST00000409404.2_Silent_p.L1903L|FAT3_ENST00000525166.1_Silent_p.L1753L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1903	Cadherin 17.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGAGGTTCTGAAAGTTAGTG	0.428000										TCGA Ovarian(4;0.039)			10	35					0	0	1	0	0
GBGT1	26301	broad.mit.edu	37	9	136030652	136030652	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136030652G>A	ENST00000372040.3	-	6	583	c.272C>T	c.(271-273)tCc>tTc	p.S91F	RALGDS_ENST00000542690.1_Silent_p.L103L|GBGT1_ENST00000372038.3_Silent_p.L103L|GBGT1_ENST00000540636.1_Missense_Mutation_p.S74F|GBGT1_ENST00000472281.1_5'UTR|GBGT1_ENST00000372043.3_Missense_Mutation_p.S91F					globoside alpha-1,3-N-acetylgalactosaminyltransferase 1											breast(2)|endometrium(1)|kidney(4)|lung(2)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		GGTTCCCTCGGAGACGATGGG	0.617000													10	26					0	0	1	0	0
AQP10	89872	broad.mit.edu	37	1	154296247	154296247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154296247C>T	ENST00000484864.1	+	5	708	c.672C>T	c.(670-672)ttC>ttT	p.F224F	AQP10_ENST00000324978.3_Silent_p.F224F|AQP10_ENST00000355197.4_3'UTR			Q96PS8	AQP10_HUMAN	aquaporin 10	224					response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity	p.F224F(1)		central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|stomach(2)|upper_aerodigestive_tract(1)	23	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CACGTCTCTTCACCTACGTGG	0.627000													13	48					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113924290	113924290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:113924290G>A	ENST00000348367.4	-	13	1497	c.1300C>T	c.(1300-1302)Cct>Tct	p.P434S	GPAM_ENST00000369425.1_Missense_Mutation_p.P434S|GPAM_ENST00000423155.1_Missense_Mutation_p.P434S			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	434					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TACCTTGAAGGAAGTATAGCT	0.358000													14	46					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97158976	97158976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:97158976C>T	ENST00000524981.3	+	27	3614	c.3614C>T	c.(3613-3615)tCg>tTg	p.S1205L				Q6ZTY8	CL063_HUMAN		1179										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						CTTTTGTCTTCGTATACAGAT	0.289000													26	73					0	0	1	0	0
NOL9	79707	broad.mit.edu	37	1	6610651	6610651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6610651G>A	ENST00000377705.5	-	2	453	c.421C>T	c.(421-423)Cgt>Tgt	p.R141C		NM_024654.4	NP_078930.3	Q5SY16	NOL9_HUMAN	nucleolar protein 9	141					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(2)|urinary_tract(1)	19	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGTCACACGACAGATCCCA	0.413000													21	58					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251824	25251824	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:25251824C>T	ENST00000328086.7	-	7	3020	c.2217G>A	c.(2215-2217)caG>caA	p.Q739Q		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	739					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		CAAAAGGCCTCTGATGCACAA	0.488000													23	77					0	0	1	0	0
AC010731.4	0	broad.mit.edu	37	2	207509150	207509150	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207509150C>T	ENST00000543490.1	+	0	365																											GTGGAAACCTCGCGTTTCCAA	0.488000													5	35					0	0	1	0	0
HLA-DRA	3122	broad.mit.edu	37	6	32411228	32411228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32411228C>T	ENST00000395388.2	+	3	704	c.595C>T	c.(595-597)Ctt>Ttt	p.L199F	HLA-DRA_ENST00000374982.5_Missense_Mutation_p.L174F	NM_019111.4	NP_061984.2	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR alpha	199	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	19						GGATGAGCCTCTTCTCAAGCA	0.493000									T-cell Lymphoma, (Cutaneous) , Familial Clustering of;Kaposi Sarcoma, Familial Clustering of				21	90					0	0	1	0	0
SIRT2	22933	broad.mit.edu	37	19	39384091	39384091	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39384091G>A	ENST00000249396.7	-	4	490	c.189C>T	c.(187-189)acC>acT	p.T63T	SIRT2_ENST00000392081.2_Silent_p.T26T|SIRT2_ENST00000358931.5_Silent_p.T63T	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	63					cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			CCCCTTCCAAGGTCAGCTCGT	0.612000													13	28					0	0	1	0	0
ZC3H11A	9877	broad.mit.edu	37	1	203819693	203819693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203819693C>T	ENST00000545588.1	+	15	5817	c.1990C>T	c.(1990-1992)Ccc>Tcc	p.P664S	ZC3H11A_ENST00000367214.1_Missense_Mutation_p.P664S|ZC3H11A_ENST00000332127.4_Missense_Mutation_p.P664S|ZC3H11A_ENST00000367212.3_Missense_Mutation_p.P664S|ZC3H11A_ENST00000367210.1_Missense_Mutation_p.P664S	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	664							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTGTCATCCCCCAAATTGGC	0.488000													38	124					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736879	140736879	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140736879C>T	ENST00000571252.1	+	1	2112	c.2112C>T	c.(2110-2112)ttC>ttT	p.F704F	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGCGTCTTCCTGGCTTTTG	0.612000													22	51					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42797233	42797233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42797233C>T	ENST00000314073.5	+	6	1338	c.1162C>T	c.(1162-1164)Cat>Tat	p.H388Y	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.H388Y					GLTSCR1-like																		TATTGTTATTCATTCCCCCAT	0.488000													63	287					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103442133	103442133	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103442133G>A	ENST00000361246.2	-	11	1683	c.1395C>T	c.(1393-1395)acC>acT	p.T465T		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	465					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GCACGGTCTGGGTGGACTCTG	0.597000													12	221					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608595	4608595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4608595G>A	ENST00000312614.4	+	1	575	c.553G>A	c.(553-555)Gcc>Acc	p.A185T		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCTATCATAGCCATAACTCC	0.493000													37	87					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189590653	189590653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189590653G>A	ENST00000264731.3	+	10	1307	c.1218G>A	c.(1216-1218)agG>agA	p.R406R	TP63_ENST00000392460.3_Silent_p.R406R|TP63_ENST00000449992.1_Silent_p.R227R|TP63_ENST00000392463.2_Silent_p.R312R|TP63_ENST00000440651.2_Silent_p.R402R|TP63_ENST00000320472.5_Silent_p.R406R|TP63_ENST00000392461.3_Silent_p.R312R|TP63_ENST00000382063.4_Silent_p.R321R|TP63_ENST00000456148.1_Silent_p.R308R|TP63_ENST00000437221.1_Silent_p.R312R|TP63_ENST00000354600.5_Silent_p.R312R|TP63_ENST00000418709.2_Silent_p.R406R	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	406	Oligomerization.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CATAGGTGAGGGGCCGTGAGA	0.438000										HNSCC(45;0.13)			15	35					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58206895	58206895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58206895C>T	ENST00000377918.3	+	1	241	c.215C>T	c.(214-216)cCg>cTg	p.P72L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	72	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AACTCCGCACCGCACCTGCTG	0.687000													12	28					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51851266	51851266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51851266C>T	ENST00000453097.2	+	6	923	c.706C>T	c.(706-708)Cgc>Tgc	p.R236C	SLC4A8_ENST00000394856.1_Missense_Mutation_p.R183C|SLC4A8_ENST00000514353.3_Missense_Mutation_p.R183C|SLC4A8_ENST00000358657.3_Missense_Mutation_p.R263C|SLC4A8_ENST00000535225.2_Missense_Mutation_p.R183C	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	236					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TCCCATTGTTCGCTCCTTTGC	0.393000													24	85					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141336442	141336442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141336442C>T	ENST00000231484.3	-	1	2185	c.975G>A	c.(973-975)agG>agA	p.R325R		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	325	Cadherin 3.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCCAGGTCCCTTGCCTGAA	0.522000													25	56					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990342	63990342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:63990342C>T	ENST00000370657.4	-	4	1147	c.1114G>A	c.(1114-1116)Gac>Aac	p.D372N	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	372					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	TCTTTCCTGTCCTTGGAATAA	0.478000													52	149					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40714389	40714389	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40714389G>A	ENST00000373198.3	-	29	4252	c.4017C>T	c.(4015-4017)ttC>ttT	p.F1339F	PTPRT_ENST00000373193.3_Silent_p.F1320F|PTPRT_ENST00000373184.1_Silent_p.F1327F|PTPRT_ENST00000373201.1_Silent_p.F1307F|PTPRT_ENST00000373190.1_Silent_p.F1316F|PTPRT_ENST00000373187.1_Silent_p.F1317F|PTPRT_ENST00000356100.2_Silent_p.F1326F	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1317	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TACAGATGCGGAATATTCTGT	0.587000													6	91					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058235	11058235	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11058235C>T	ENST00000470054.1	-	0	412									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGTGTCGGCTCCTGCAGCACA	0.428000													12	134					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756466	56756466	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56756466C>T	ENST00000326855.2	+	1	120	c.78C>T	c.(76-78)atC>atT	p.I26I		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						TTTGGTGTATCCTCTTCATTG	0.393000													41	161					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57430138	57430138	+	Missense_Mutation	SNP	G	G	A	rs143613424	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57430138G>A	ENST00000442789.2	-	23	2589	c.2302C>T	c.(2302-2304)Cgg>Tgg	p.R768W	MYO1A_ENST00000300119.3_Missense_Mutation_p.R768W|MYO1A_ENST00000544473.1_Missense_Mutation_p.R606W	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	768	IQ 3.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						GCCTCTGACCGGAAATATTTG	0.468000													49	154					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226032	158226032	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158226032G>A	ENST00000289429.5	+	3	1097	c.564G>A	c.(562-564)ttG>ttA	p.L188L		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	188	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GTTTCATCTTGGGTCTTCTTG	0.463000													17	86					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	36007457	36007457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:36007457C>T	ENST00000297866.5	+	16	2801	c.2735C>T	c.(2734-2736)tCa>tTa	p.S912L		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	912										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GCATATTCCTCACTGGAATGT	0.353000													18	27					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169432736	169432736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169432736C>T	ENST00000261509.6	+	2	292	c.81C>T	c.(79-81)ttC>ttT	p.F27F	PALLD_ENST00000333488.4_5'UTR|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Silent_p.F27F	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	27					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CTGACTTCTTCCCGGGCCTTT	0.502000									Pancreatic Cancer, Familial Clustering of				18	69					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588260	247588260	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247588260G>A	ENST00000366497.2	+	4	2295	c.1515G>A	c.(1513-1515)atG>atA	p.M505I	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Missense_Mutation_p.M505I|NLRP3_ENST00000336119.3_Missense_Mutation_p.M505I|NLRP3_ENST00000348069.2_Missense_Mutation_p.M505I|NLRP3_ENST00000391828.3_Missense_Mutation_p.M505I|NLRP3_ENST00000391827.2_Missense_Mutation_p.M505I	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	505	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCTGAGGATGAACCTGTTCC	0.502000													23	40					0	0	1	0	0
ZNF548	147694	broad.mit.edu	37	19	57910226	57910226	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57910226C>T	ENST00000366197.5	+	3	821	c.571C>T	c.(571-573)Cag>Tag	p.Q191*	ZNF548_ENST00000336128.7_Nonsense_Mutation_p.Q203*|AC003002.6_ENST00000600421.1_Intron|AC004076.7_ENST00000597410.1_Intron|AC003002.6_ENST00000596400.1_Intron	NM_152909.3	NP_690873.2	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGAAGCCTTTCAGACTGGACA	0.498000													23	74					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44019227	44019227	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44019227C>T	ENST00000359947.4	+	4	496	c.156C>T	c.(154-156)ttC>ttT	p.F52F	PTPRF_ENST00000438120.1_Silent_p.F52F|PTPRF_ENST00000372414.3_Silent_p.F52F|PTPRF_ENST00000372413.3_Silent_p.F52F	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	52	Ig-like C2-type 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TAGCCTCCTTCGTGTGCCAAG	0.562000													98	240					0	0	1	0	0
ESD	2098	broad.mit.edu	37	13	47355713	47355713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:47355713G>A	ENST00000378720.3	-	7	601	c.419C>T	c.(418-420)cCc>cTc	p.P140L	ESD_ENST00000495654.1_5'UTR|ESD_ENST00000378697.1_Missense_Mutation_p.P111L	NM_001984.1	NP_001975.1	P10768	ESTD_HUMAN	esterase D	140						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)	9		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	CATCCTTTGGGGATCCACTGG	0.353000													43	131					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69881775	69881775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:69881775G>A	ENST00000358913.5	+	2	1068	c.580G>A	c.(580-582)Gaa>Aaa	p.E194K	MYPN_ENST00000354393.2_Intron|MYPN_ENST00000540630.1_Missense_Mutation_p.E194K|MYPN_ENST00000373675.3_Missense_Mutation_p.E194K	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	194	Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						AGTTATGCAGGAAAACAGCTC	0.448000													21	74					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151134155	151134155	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151134155C>T	ENST00000474524.1	+	41	6286	c.6248C>T	c.(6247-6249)tCg>tTg	p.S2083L	MED12L_ENST00000273432.4_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	2083	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			cagcagTCCTCGCAGTCCCAG	0.532000													21	71					0	0	1	0	0
PARP4	143	broad.mit.edu	37	13	25008807	25008807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25008807G>A	ENST00000381989.3	-	31	4577	c.4472C>T	c.(4471-4473)tCc>tTc	p.S1491F		NM_006437.3	NP_006428.2	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1491					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(18)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		GGTAGTCCGGGACTGACTGCA	0.488000													6	68					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52521021	52521021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52521021G>A	ENST00000216286.5	-	4	785	c.786C>T	c.(784-786)atC>atT	p.I262I	NID2_ENST00000541773.1_Silent_p.I209I	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	262	NIDO.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					ACACTCCAGGGATCCCCAGGT	0.483000													8	42					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657090	143657090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143657090G>A	ENST00000392899.1	+	1	64	c.27G>A	c.(25-27)gtG>gtA	p.V9V		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					AGACTTGGGTGAGTGAATTTA	0.428000													45	132					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53185105	53185105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53185105C>T	ENST00000417996.2	-	7	1494	c.1420G>A	c.(1420-1422)Gcg>Acg	p.A474T	KRT3_ENST00000309505.3_Missense_Mutation_p.A474T	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	474	Coil 2.|Rod.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						TCATCCTTCGCCTGCTGTAGA	0.612000													42	80					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23809324	23809324	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23809324C>T	ENST00000354639.3	+	13	2057	c.1593C>T	c.(1591-1593)atC>atT	p.I531I	STK31_ENST00000433467.2_Silent_p.I554I|STK31_ENST00000355870.3_Silent_p.I554I|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Silent_p.I531I	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	554							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTGATGAAATCCTAGAGAAGA	0.373000													68	181					0	0	1	0	0
NFE2L3	9603	broad.mit.edu	37	7	26224916	26224916	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:26224916G>A	ENST00000056233.3	+	4	1857	c.1598G>A	c.(1597-1599)aGa>aAa	p.R533K		NM_004289.6	NP_004280.5	Q9Y4A8	NF2L3_HUMAN	nuclear factor, erythroid 2-like 3	533					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						GACACAGATAGAAACTTGAGC	0.428000													34	83					0	0	1	0	0
TEX19	400629	broad.mit.edu	37	17	80320289	80320289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80320289G>A	ENST00000333437.4	+	2	573	c.263G>A	c.(262-264)gGa>gAa	p.G88E		NM_207459.3	NP_997342.1	Q8NA77	TEX19_HUMAN	testis expressed 19	88						nucleus				breast(1)|endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	6						CAGAGCCCAGGACAGCCTGTG	0.647000													13	58					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087887	9087887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9087887G>A	ENST00000397910.4	-	1	4131	c.3928C>T	c.(3928-3930)Cct>Tct	p.P1310S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1310	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTCTCCAGGAGCTGTCATC	0.507000													24	65					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5541334	5541334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5541334G>A	ENST00000382368.3	-	3	689	c.566C>T	c.(565-567)cCc>cTc	p.P189L	FBXL18_ENST00000453700.3_Missense_Mutation_p.P189L	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	189									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GGTGCAGCAGGGCACCACGCC	0.662000													3	15					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155203216	155203216	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155203216T>C	ENST00000460012.1	-	22	3170	c.2813A>G	c.(2812-2814)aAc>aGc	p.N938S	PLCH1_ENST00000334686.6_Missense_Mutation_p.N938S|PLCH1_ENST00000494598.1_Missense_Mutation_p.N956S|PLCH1_ENST00000447496.2_Missense_Mutation_p.N976S|PLCH1_ENST00000340059.7_Missense_Mutation_p.N976S|PLCH1_ENST00000414191.1_Missense_Mutation_p.N938S			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	976					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCCAGAAGGTTTCTGTCAAC	0.468000													35	103					0	0	1	0	0
WWTR1	25937	broad.mit.edu	37	3	149290715	149290715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:149290715G>A	ENST00000465804.1	-	4	760	c.504C>T	c.(502-504)ctC>ctT	p.L168L	WWTR1_ENST00000467467.1_Silent_p.L168L|WWTR1_ENST00000360632.3_Silent_p.L168L	NM_001168278.1	NP_001161750.1	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	168					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	23			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CGGCAGGGTGGAGGTTCATAT	0.418000			T	CAMTA1	epitheliod hemangioendothelioma								39	82					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160050863	160050863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160050863C>T	ENST00000263635.6	+	17	3075	c.2838C>T	c.(2836-2838)ggC>ggT	p.G946G	TANC1_ENST00000454300.1_Silent_p.G840G	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	946						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CTCACCTTGGCCACGAGGAAG	0.557000													27	65					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250719	140250719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140250719C>T	ENST00000398640.2	+	1	2031	c.2031C>T	c.(2029-2031)gcC>gcT	p.A677A	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCAAAGGCCTCTTCCCGGA	0.652000													7	82					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74367329	74367329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74367329G>A	ENST00000290438.3	-	11	901	c.861C>T	c.(859-861)tcC>tcT	p.S287S		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	287										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						GGGGCGCCAGGGATGGGGGCT	0.552000													29	108					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207564903	207564903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207564903G>A	ENST00000452335.2	-	6	637	c.521C>T	c.(520-522)cCt>cTt	p.P174L	DYTN_ENST00000477734.1_5'UTR	NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	174						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		ACTTTCCACAGGGCACAGAGC	0.527000													35	79					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176011643	176011643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176011643G>A	ENST00000510636.1	+	19	2635	c.2361G>A	c.(2359-2361)ggG>ggA	p.G787G	CDHR2_ENST00000261944.5_Silent_p.G787G|CDHR2_ENST00000506348.1_Silent_p.G787G	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	787	Cadherin 7.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						ACCCCCAGGGGGGTGAGACCA	0.602000													13	125					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354074	57354074	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57354074C>T	ENST00000314922.3	-	2	637	c.561G>A	c.(559-561)ggG>ggA	p.G187G	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Silent_p.G187G	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	187					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TCATGAAGCCCCCATATCTCT	0.522000													53	129					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44087626	44087626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44087626C>T	ENST00000359947.4	+	34	6016	c.5676C>T	c.(5674-5676)taC>taT	p.Y1892Y	PTPRF_ENST00000422171.2_Silent_p.Y1251Y|PTPRF_ENST00000438120.1_Silent_p.Y1883Y|PTPRF_ENST00000372414.3_Silent_p.Y1892Y|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Silent_p.Y1883Y	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1892	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGCTGTGCTACCGTGCGGCCC	0.652000													30	81					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100623260	100623260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:100623260C>T	ENST00000317233.4	-	6	942	c.707G>A	c.(706-708)aGg>aAg	p.R236K	AFF3_ENST00000409236.1_Missense_Mutation_p.R236K|AFF3_ENST00000409579.1_Missense_Mutation_p.R261K|AFF3_ENST00000356421.2_Missense_Mutation_p.R261K	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	236					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GTCCATTGGCCTCACATACGC	0.577000													18	48					0	0	1	0	0
CLCF1	23529	broad.mit.edu	37	11	67133074	67133074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67133074C>T	ENST00000312438.7	-	3	408	c.211G>A	c.(211-213)Gag>Aag	p.E71K	CLCF1_ENST00000528474.1_Missense_Mutation_p.E61K|AP003419.11_ENST00000543494.1_RNA|CLCF1_ENST00000533438.1_Missense_Mutation_p.E61K	NM_013246.2	NP_037378.1	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1	71					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			endometrium(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			AAGTCTGGCTCGTTGAAAGGG	0.612000													31	82					0	0	1	0	0
SRPX2	27286	broad.mit.edu	37	X	99917296	99917296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:99917296G>A	ENST00000373004.3	+	4	715	c.287G>A	c.(286-288)cGa>cAa	p.R96Q		NM_014467.2	NP_055282.1	O60687	SRPX2_HUMAN	sushi-repeat containing protein, X-linked 2	96	Sushi 1.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|upper_aerodigestive_tract(1)	19						CGGGGCTTTCGATTGATTGGA	0.537000													18	79					0	0	1	0	0
SHC2	25759	broad.mit.edu	37	19	430734	430734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:430734G>A	ENST00000264554.6	-	9	1123	c.1124C>T	c.(1123-1125)tCt>tTt	p.S375F		NM_012435.2	NP_036567.2	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing) transforming protein 2	375	CH1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol				endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTCTTAGAGAAGGAGATGG	0.647000													8	29					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996538	143996538	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143996538C>T	ENST00000323110.2	-	3	521	c.519G>A	c.(517-519)aaG>aaA	p.K173K		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	173			K -> R (in dbSNP:rs4539).		aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCACCTTCTTCTTCAGGGCCT	0.627000									Familial Hyperaldosteronism type I				3	19					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149449834	149449834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149449834G>A	ENST00000286301.3	-	9	1521	c.1230C>T	c.(1228-1230)ttC>ttT	p.F410F		NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	410	Ig-like C2-type 5.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	AGCCGTTGATGAATGTCCATA	0.572000													17	48					0	0	1	0	0
GSR	2936	broad.mit.edu	37	8	30567359	30567359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30567359G>A	ENST00000221130.5	-	3	484	c.394C>T	c.(394-396)Cca>Tca	p.P132S	GSR_ENST00000546342.1_Missense_Mutation_p.P132S|GSR_ENST00000537535.1_Missense_Mutation_p.P132S|GSR_ENST00000414019.1_Missense_Mutation_p.P89S|GSR_ENST00000541648.1_Missense_Mutation_p.P132S	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	132					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TCACAACTTGGAAAGCCATAA	0.363000													9	33					0	0	1	0	0
TRIM63	84676	broad.mit.edu	37	1	26393830	26393830	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26393830G>A	ENST00000374272.3	-	1	294	c.156C>T	c.(154-156)ttC>ttT	p.F52F	TRIM63_ENST00000483052.1_5'UTR	NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	52						cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CACTTACCTGGAAGATGTCAT	0.557000													12	27					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85696067	85696067	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:85696067G>A	ENST00000322366.6	-	29	5067	c.4660C>T	c.(4660-4662)Cga>Tga	p.R1554*	WDFY3_ENST00000295888.4_Nonsense_Mutation_p.R1554*			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1554						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GACATATCTCGAAGAGTCAGG	0.398000													47	99					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915289	119915289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:119915289G>A	ENST00000331113.4	+	1	1568	c.603G>A	c.(601-603)gcG>gcA	p.A201A		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	201					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					CTGTCATCGCGAATGTGGTGG	0.572000													8	68					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4073527	4073527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:4073527C>T	ENST00000274673.3	-	6	687	c.284G>A	c.(283-285)gGa>gAa	p.G95E	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	95																	TATGGTACTTCCTTCATTAAG	0.299000													8	106					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58115674	58115674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58115674C>T	ENST00000332854.6	+	2	280	c.60C>T	c.(58-60)gcC>gcT	p.A20A	ZNF530_ENST00000597864.1_5'UTR	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGGATGTGGCCATTTACTTCT	0.507000													17	178					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440697	40440697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40440697C>T	ENST00000319592.4	-	4	923	c.214G>A	c.(214-216)Gag>Aag	p.E72K	RBM47_ENST00000381793.2_Missense_Mutation_p.E72K|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381795.6_Missense_Mutation_p.E72K|RBM47_ENST00000514014.1_Missense_Mutation_p.E34K|RBM47_ENST00000295971.7_Missense_Mutation_p.E72K			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	72	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						ACGAAGACCTCGCAGCCACGC	0.692000													11	30					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690654	33690654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33690654C>T	ENST00000394566.1	-	4	445	c.173G>A	c.(172-174)gGa>gAa	p.G58E	SLFN11_ENST00000308377.4_Missense_Mutation_p.G58E	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	58						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AATCACTCCTCCTCCTGAGTT	0.448000													60	116					0	0	1	0	0
MOS	4342	broad.mit.edu	37	8	57026446	57026446	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57026446C>T	ENST00000311923.1	-	1	95	c.96G>A	c.(94-96)gcG>gcA	p.A32A		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog	32							ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			GAAGCAGCTTCGCAGGTAGCT	0.701000													13	22					0	0	1	0	0
CLP1	10978	broad.mit.edu	37	11	57427291	57427291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57427291C>T	ENST00000533682.1	+	2	1068	c.343C>T	c.(343-345)Ccc>Tcc	p.P115S	CLP1_ENST00000302731.4_Missense_Mutation_p.P115S|CLP1_ENST00000525602.1_Missense_Mutation_p.P115S|CLP1_ENST00000529430.1_Missense_Mutation_p.P126S			Q92989	CLP1_HUMAN	cleavage and polyadenylation factor I subunit 1	115					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|stomach(1)	15						AGAGCGAGGTCCCCGAGTGAT	0.552000													14	42					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23328614	23328614	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23328614C>T	ENST00000597761.2	+	4	967	c.768C>T	c.(766-768)taC>taT	p.Y256Y		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						AAAAACCCTACCAATGTGAGA	0.333000													3	18					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131339657	131339657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131339657C>T	ENST00000372739.3	+	8	1067	c.957C>T	c.(955-957)gaC>gaT	p.D319D	SPTAN1_ENST00000372731.4_Silent_p.D319D|SPTAN1_ENST00000358161.5_Silent_p.D319D	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	319					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						CTGAGGCTGACCGCCTGCAAC	0.498000													33	67					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926806	1926806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1926806C>T	ENST00000399161.2	-	10	1482	c.735G>A	c.(733-735)cgG>cgA	p.R245R	MYT1L_ENST00000428368.2_Silent_p.R245R	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	245					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ACTCACTTTTCCGACCCAGGT	0.458000													42	113					0	0	1	0	0
EXT2	2132	broad.mit.edu	37	11	44148446	44148446	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:44148446C>T	ENST00000395673.3	+	6	1175	c.1119C>T	c.(1117-1119)gtC>gtT	p.V373V	EXT2_ENST00000533608.1_Silent_p.V340V|EXT2_ENST00000343631.3_Silent_p.V340V|EXT2_ENST00000358681.4_Silent_p.V340V	NM_000401.3	NP_000392.3	Q93063	EXT2_HUMAN	exostosin glycosyltransferase 2	340					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|lung(17)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	32						CTGGCTGTGTCCCGGTTGTCA	0.498000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Hereditary Multiple Exostoses				37	110					0	0	1	0	0
UPK3A	7380	broad.mit.edu	37	22	45683229	45683229	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45683229C>T	ENST00000216211.4	+	3	417	c.385C>T	c.(385-387)Ctg>Ttg	p.L129L	UPK3A_ENST00000396082.2_Intron	NM_006953.3	NP_008884.1	O75631	UPK3A_HUMAN	uroplakin 3A	129					epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane				kidney(1)|large_intestine(1)|lung(2)|skin(1)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CTCACAGATCCTGAATGCCTA	0.612000													9	25					0	0	1	0	0
E2F3	1871	broad.mit.edu	37	6	20490515	20490515	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:20490515C>T	ENST00000346618.3	+	7	1318	c.1252C>T	c.(1252-1254)Cta>Tta	p.L418L	E2F3_ENST00000535432.1_Silent_p.L287L	NM_001949.4	NP_001940.1	O00716	E2F3_HUMAN	E2F transcription factor 3	418	Transactivation (Potential).				G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(3)	7	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			TCCTTCCAACCTAGAAGGACC	0.527000													28	79					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130282378	130282378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130282378G>A	ENST00000358511.6	+	2	562	c.531G>A	c.(529-531)atG>atA	p.M177I	COL6A6_ENST00000453409.2_Missense_Mutation_p.M177I	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	177	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TGAAGGCCATGGCCACGTCTC	0.463000													8	68					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073562	9073562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9073562C>T	ENST00000397910.4	-	3	14087	c.13884G>A	c.(13882-13884)ggG>ggA	p.G4628G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4630	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTAATAGCCCCCACAGACA	0.458000													19	62					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230162	39230162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39230162C>T	ENST00000340369.3	-	2	1003	c.775G>A	c.(775-777)Gag>Aag	p.E259K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.E259K	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	259							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGGATCTCCTCCCGGCATGCG	0.622000													37	91					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084368	152084368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152084368C>T	ENST00000368804.1	-	2	1324	c.1325G>A	c.(1324-1326)aGg>aAg	p.R442K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	442	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ctgctcgcgcctctcctgctc	0.692000													22	89					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63668267	63668267	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63668267C>T	ENST00000402010.2	+	10	1483	c.904C>T	c.(904-906)Cga>Tga	p.R302*	MARK2_ENST00000361128.5_Nonsense_Mutation_p.R302*|MARK2_ENST00000513765.2_Nonsense_Mutation_p.R269*|MARK2_ENST00000315032.8_Nonsense_Mutation_p.R302*|MARK2_ENST00000350490.7_Nonsense_Mutation_p.R302*|MARK2_ENST00000425897.2_Nonsense_Mutation_p.R269*|MARK2_ENST00000377809.4_Nonsense_Mutation_p.R302*|MARK2_ENST00000502399.3_Nonsense_Mutation_p.R302*|MARK2_ENST00000377810.3_Nonsense_Mutation_p.R269*|MARK2_ENST00000408948.3_Nonsense_Mutation_p.R269*|MARK2_ENST00000508192.1_Nonsense_Mutation_p.R302*|MARK2_ENST00000509502.2_Nonsense_Mutation_p.R269*|MARK2_ENST00000413835.2_Nonsense_Mutation_p.R302*	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	302	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CATGAAAGATCGATGGATGAA	0.562000													24	275					0	0	1	0	0
DNM1P34	729809	broad.mit.edu	37	15	75595057	75595057	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75595057C>T	ENST00000567292.1	-	0	249																											CTCCAGGCATCCCCAGGATCT	0.607000													3	8					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107416969	107416969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107416969C>T	ENST00000340010.5	-	15	1789	c.1605G>A	c.(1603-1605)gtG>gtA	p.V535V	SLC26A3_ENST00000422236.2_Silent_p.V500V	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	535	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TGAAAATTTTCACTCCTTCTG	0.358000													23	91					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76464763	76464763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76464763C>T	ENST00000389840.5	-	55	8796	c.8672G>A	c.(8671-8673)gGc>gAc	p.G2891D	DNAH17_ENST00000585328.1_Missense_Mutation_p.G2900D|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTCATTCATGCCAAGGGACTT	0.552000													12	37					0	0	1	0	0
ACTR2	10097	broad.mit.edu	37	2	65482733	65482733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:65482733C>T	ENST00000260641.5	+	6	797	c.640C>T	c.(640-642)Cgc>Tgc	p.R214C	ACTR2_ENST00000542850.1_Missense_Mutation_p.R159C|ACTR2_ENST00000377982.4_Missense_Mutation_p.R219C	NM_005722.3	NP_005713.1	P61160	ARP2_HUMAN	ARP2 actin-related protein 2 homolog (yeast)	214					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)	12						TGAAACGGTTCGCATGATTAA	0.373000													46	102					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458358	45458358	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45458358G>A	ENST00000548424.1	+	0	448																											CTGCTGTTCAGGGTGGGGTCA	0.517000													11	24					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7439304	7439304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7439304C>T	ENST00000318881.6	+	5	1519	c.1282C>T	c.(1282-1284)Cct>Tct	p.P428S		NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	428	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CTTTGATGTCCCTCCCGAGAA	0.478000													17	77					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20432301	20432301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:20432301G>A	ENST00000377252.3	+	5	1460	c.619G>A	c.(619-621)Gat>Aat	p.D207N	PLXDC2_ENST00000377238.2_3'UTR|PLXDC2_ENST00000377242.3_Missense_Mutation_p.D158N	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	207						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						GGCAAATTTCGATCCCAGTGT	0.353000													46	104					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41459131	41459131	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41459131C>T	ENST00000400454.1	-	22	4411	c.3934G>A	c.(3934-3936)Gac>Aac	p.D1312N		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1312	Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGAGAAGGGTCCCCAACAGCC	0.463000													27	68					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200967555	200967555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200967555G>A	ENST00000332129.2	-	14	2350	c.2034C>T	c.(2032-2034)atC>atT	p.I678I	KIF21B_ENST00000461742.2_Silent_p.I678I|KIF21B_ENST00000360529.5_Silent_p.I678I|KIF21B_ENST00000422435.2_Silent_p.I678I	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	678					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GTGTGTCTCGGATCTTGTTCT	0.602000													35	116					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227216844	227216844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:227216844G>A	ENST00000366769.3	-	29	5132	c.3841C>T	c.(3841-3843)Cct>Tct	p.P1281S	CDC42BPA_ENST00000334218.5_Missense_Mutation_p.P1281S|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.P1200S|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.P1294S|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.P1316S|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.P1253S|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.P1261S	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1294	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				GCTGACATAGGAAAAAGTCGT	0.433000													12	53					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54823363	54823363	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54823363C>T	ENST00000301219.3	-	4	299	c.180G>A	c.(178-180)ggG>ggA	p.G60G	LILRA5_ENST00000346508.3_Silent_p.G48G|LILRA5_ENST00000446712.3_Silent_p.G48G|LILRA5_ENST00000432233.3_Silent_p.G60G|AC008984.2_ENST00000507363.1_RNA	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	60	Ig-like C2-type 1.				innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACAGAGTTCCCCCGGCTGA	0.612000													35	88					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47681866	47681866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47681866C>T	ENST00000283303.2	+	6	1143	c.885C>T	c.(883-885)ttC>ttT	p.F295F	GPR115_ENST00000327753.3_Silent_p.F295F|GPR115_ENST00000371220.1_Silent_p.F352F	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	295					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						GCATAGCTTTCCCAACCTTGG	0.468000													22	43					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14797324	14797324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:14797324C>T	ENST00000403951.2	-	3	522	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	DGKB_ENST00000402815.1_Missense_Mutation_p.E35K|DGKB_ENST00000258767.5_Missense_Mutation_p.E35K|DGKB_ENST00000444700.2_Missense_Mutation_p.E35K|DGKB_ENST00000399322.3_Missense_Mutation_p.E35K|DGKB_ENST00000407950.1_Missense_Mutation_p.E35K|DGKB_ENST00000406247.3_Missense_Mutation_p.E35K|DGKB_ENST00000403963.1_5'UTR			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	35					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CCATGGAATTCTTCAAGAACA	0.328000													14	51					0	0	1	0	0
PSMB11	122706	broad.mit.edu	37	14	23511881	23511881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23511881C>T	ENST00000408907.2	+	1	506	c.447C>T	c.(445-447)gcC>gcT	p.A149A		NM_001099780.1	NP_001093250.1	A5LHX3	PSB11_HUMAN	proteasome (prosome, macropain) subunit, beta type, 11	149					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(1)|kidney(2)|lung(4)	7	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		TGGCCACTGCCCTCTGCGGCT	0.617000													33	56					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053934	133053934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133053934G>A	ENST00000262283.5	-	8	869	c.770C>T	c.(769-771)cCc>cTc	p.P257L	OC90_ENST00000443356.2_Missense_Mutation_p.P61L|OC90_ENST00000254627.3_Missense_Mutation_p.P61L|OC90_ENST00000603859.1_Missense_Mutation_p.P61L			Q02509	OC90_HUMAN	otoconin 90	61					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GGTGAAGTGGGGGCCCAGGCA	0.587000													9	17					0	0	1	0	0
NEDD1	121441	broad.mit.edu	37	12	97339584	97339584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:97339584C>T	ENST00000266742.4	+	14	2107	c.1768C>T	c.(1768-1770)Cgt>Tgt	p.R590C	NEDD1_ENST00000557644.1_Missense_Mutation_p.R597C|NEDD1_ENST00000411739.2_Missense_Mutation_p.R501C|NEDD1_ENST00000457368.2_Missense_Mutation_p.R501C|NEDD1_ENST00000429527.2_Missense_Mutation_p.R590C	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	590					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol		p.R590C(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						CATTCAAATTCGTTTTATTCA	0.373000													33	54					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155720128	155720128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155720128G>A	ENST00000510397.1	+	4	993	c.814G>A	c.(814-816)Gat>Aat	p.D272N	RBM46_ENST00000514866.1_Missense_Mutation_p.D272N|RBM46_ENST00000281722.3_Missense_Mutation_p.D272N	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	272	RRM 3.						nucleotide binding|RNA binding	p.D272Y(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				GAAACTTAGAGATTATGCTTT	0.353000													18	50					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52539740	52539740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52539740G>A	ENST00000261839.7	-	15	1957	c.1796C>T	c.(1795-1797)cCt>cTt	p.P599L	MYO5C_ENST00000443683.2_3'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	599	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		TGAACCAAAAGGAGAAGGAGG	0.438000													30	79					0	0	1	0	0
KHDC1	80759	broad.mit.edu	37	6	73951407	73951407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73951407C>T	ENST00000370384.3	-	5	1059	c.559G>A	c.(559-561)Gat>Aat	p.D187N	KHDC1_ENST00000257765.5_Missense_Mutation_p.D114N|RP11-257K9.8_ENST00000423730.3_Intron	NM_001251874.1	NP_001238803.1	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	187						integral to membrane	RNA binding			large_intestine(1)|lung(4)|skin(1)	6						ACCAGGTCATCGTTGGTCAGA	0.557000													9	64					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43157211	43157211	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:43157211G>A	ENST00000522175.2	+	0	697							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATGTATTTGGACAAACTGCT	0.308000													6	75					0	0	1	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46120880	46120880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46120880G>A	ENST00000355105.3	-	5	1532	c.172C>T	c.(172-174)Ccc>Tcc	p.P58S	GPBP1L1_ENST00000290795.3_Missense_Mutation_p.P58S	NM_021639.4	NP_067652.1	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	58					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding		GPBP1L1/MAST2_ENST00000361297(2)	breast(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|stomach(1)	21	Acute lymphoblastic leukemia(166;0.155)					GTTCGTAGGGGACCATTGTTA	0.463000													46	85					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879424	3879424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3879424G>A	ENST00000315677.3	-	4	1240	c.645C>T	c.(643-645)taC>taT	p.Y215Y	DLGAP1_ENST00000584874.1_Silent_p.Y215Y|DLGAP1_ENST00000581527.1_Silent_p.Y215Y|DLGAP1_ENST00000515196.2_Silent_p.Y215Y|DLGAP1-AS3_ENST00000577649.1_RNA	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	215					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				AGGGGGCGTGGTAGATGCACA	0.677000													52	140					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52830625	52830625	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52830625G>A	ENST00000449956.2	+	3	249	c.243G>A	c.(241-243)gtG>gtA	p.V81V	ITIH3_ENST00000416872.2_Silent_p.V81V	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	81	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CCTTTGATGTGGAGCTGCCCA	0.567000													8	21					0	0	1	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51629059	51629059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51629059C>T	ENST00000440804.3	+	2	694	c.627C>T	c.(625-627)acC>acT	p.T209T	SIGLEC9_ENST00000250360.3_Silent_p.T209T	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	209	Ig-like C2-type 1.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ACCATGGCACCAGCCTCACCT	0.652000													11	120					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501656	140501656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140501656C>T	ENST00000194152.1	+	1	76	c.76C>T	c.(76-78)Cgc>Tgc	p.R26C		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		26					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTCTCAGGTTCGCCTCGAGCC	0.502000													27	67					0	0	1	0	0
PMS1	5378	broad.mit.edu	37	2	190670557	190670557	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:190670557C>T	ENST00000409985.1	+	4	659	c.495C>T	c.(493-495)ctC>ctT	p.L165L	PMS1_ENST00000447232.2_Intron|PMS1_ENST00000441310.2_Intron|PMS1_ENST00000374826.4_Intron|PMS1_ENST00000432292.3_Intron|PMS1_ENST00000421722.1_Intron|PMS1_ENST00000418224.3_Intron|PMS1_ENST00000409823.3_Intron			P54277	PMS1_HUMAN	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			AAAAGTTACTCGGTGAATACA	0.323000			"""Mis, N"""			"""colorectal, endometrial, ovarian"""		Direct reversal of damage;Mismatch excision repair (MMR)					3	12					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38317409	38317409	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38317409C>T	ENST00000311856.4	+	7	1108	c.1059C>T	c.(1057-1059)ctC>ctT	p.L353L	SLC22A13_ENST00000450935.2_3'UTR	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	353						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		GCCTGAGCCTCCAAGTGGGGG	0.572000													19	49					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71903228	71903228	+	Missense_Mutation	SNP	G	G	A	rs145380453		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71903228G>A	ENST00000393679.1	+	2	447	c.11G>A	c.(10-12)cGg>cAg	p.R4Q	FOLR1_ENST00000312293.4_Missense_Mutation_p.R4Q|FOLR1_ENST00000393681.2_Missense_Mutation_p.R4Q|FOLR1_ENST00000393676.3_Missense_Mutation_p.R4Q|RP11-807H22.7_ENST00000378140.3_RNA			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	4					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						ATGGCTCAGCGGATGACAACA	0.577000													25	69					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130507048	130507048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130507048C>T	ENST00000314830.8	-	7	1708	c.1595G>A	c.(1594-1596)gGg>gAg	p.G532E	SH2D3C_ENST00000429553.1_Missense_Mutation_p.G178E|SH2D3C_ENST00000373274.3_Missense_Mutation_p.G372E|SH2D3C_ENST00000420366.1_Missense_Mutation_p.G374E|SH2D3C_ENST00000471939.1_5'UTR|SH2D3C_ENST00000373277.4_Missense_Mutation_p.G375E|SH2D3C_ENST00000373276.3_Missense_Mutation_p.G464E	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	532					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTCAGGGGCCCCATTTTCTGA	0.612000													34	255					0	0	1	0	0
SSTR5	6755	broad.mit.edu	37	16	1129702	1129702	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1129702G>A	ENST00000293897.4	+	1	922	c.834G>A	c.(832-834)caG>caA	p.Q278Q	SSTR5_ENST00000397547.2_Silent_p.Q278Q|SSTR5_ENST00000562758.1_Intron	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	278					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CGCTGCCCCAGGAGCCCGCCT	0.622000													15	63					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46145989	46145989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:46145989C>T	ENST00000256413.3	+	2	348	c.53C>T	c.(52-54)tCc>tTc	p.S18F	CTIF_ENST00000382998.4_Missense_Mutation_p.S18F	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	18	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						AGCAGCCGCTCCCAGGAGATC	0.642000													4	6					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26781309	26781309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26781309G>A	ENST00000376236.4	+	3	509	c.54G>A	c.(52-54)gaG>gaA	p.E18E	APBB1IP_ENST00000356785.4_Silent_p.E18E	NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	18					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TGCTGGGAGAGATGGATCTTC	0.388000													39	96					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54142212	54142212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:54142212C>T	ENST00000265572.3	-	4	1085	c.788G>A	c.(787-789)cGa>cAa	p.R263Q	OPRK1_ENST00000520287.1_Missense_Mutation_p.R263Q|OPRK1_ENST00000524278.1_Missense_Mutation_p.R174Q|RP11-162D9.3_ENST00000524425.1_RNA	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	263					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	ATCTTTCTCTCGGGAGCCAGA	0.547000													25	51					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50752301	50752301	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50752301C>T	ENST00000440075.2	+	13	1434	c.1387C>T	c.(1387-1389)Ctg>Ttg	p.L463L	MYH14_ENST00000425460.1_Silent_p.L463L|MYH14_ENST00000376970.2_Silent_p.L455L|MYH14_ENST00000598205.1_Silent_p.L463L|MYH14_ENST00000596571.1_Silent_p.L455L|MYH14_ENST00000262269.8_Silent_p.L463L|MYH14_ENST00000601313.1_Silent_p.L463L			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	455	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CTTCCGCTGGCTGGTTCTGCG	0.667000													6	18					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88945680	88945680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:88945680C>T	ENST00000268679.4	-	11	2056	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K	CBFA2T3_ENST00000448839.1_Missense_Mutation_p.E478K|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.E516K|CBFA2T3_ENST00000360302.2_Missense_Mutation_p.E468K|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.E468K	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	554					cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E554K(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GGCCCTACCTCGCTGGAGTCC	0.697000			T	RUNX1	AML								16	41					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113679831	113679831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113679831C>T	ENST00000003302.4	-	17	2186	c.2118G>A	c.(2116-2118)atG>atA	p.M706I	USP28_ENST00000260188.5_Missense_Mutation_p.M706I|USP28_ENST00000544967.1_Missense_Mutation_p.M414I|USP28_ENST00000545540.1_Missense_Mutation_p.M581I	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	706					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TGGAGGACTCCATTTGAGGGA	0.463000													92	223					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72346770	72346770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:72346770C>T	ENST00000299687.5	+	1	3795	c.3795C>T	c.(3793-3795)ctC>ctT	p.L1265L	ZNF407_ENST00000582337.1_Silent_p.L1265L|ZNF407_ENST00000577538.1_Silent_p.L1265L|ZNF407_ENST00000309902.6_Silent_p.L1265L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GCCCTGTGCTCGTTGTGACAA	0.567000													10	29					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53683068	53683068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53683068C>T	ENST00000257934.4	+	21	4994	c.4903C>T	c.(4903-4905)Cac>Tac	p.H1635Y	ESPL1_ENST00000552462.1_Missense_Mutation_p.H1635Y	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	1635					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						GCTGCTCACCCACCTCCACAG	0.602000													10	152					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73544822	73544822	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73544822G>A	ENST00000224721.6	+	42	5697	c.5692G>A	c.(5692-5694)Ggc>Agc	p.G1898S		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1893	Cadherin 18.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CATCACTGCGGGCAACCGCGA	0.597000													25	47					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6939829	6939829	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:6939829G>A	ENST00000383032.1	+	12	1499	c.852G>A	c.(850-852)tgG>tgA	p.W284*	TBL1Y_ENST00000346432.3_Nonsense_Mutation_p.W284*|TBL1Y_ENST00000355162.2_Nonsense_Mutation_p.W284*	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	284					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						CTCTGAAATGGAACAAAAAGG	0.383000													6	14					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43385610	43385610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43385610G>A	ENST00000372851.3	-	5	586	c.520C>T	c.(520-522)Cgc>Tgc	p.R174C	RIMS4_ENST00000541604.2_Missense_Mutation_p.R175C	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	174	C2.				exocytosis|neurotransmitter transport	cell junction|synapse		p.R174C(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				AGCGACTTGCGAGCGACTTTG	0.567000													122	282					0	0	1	0	0
KRTAP12-1	353332	broad.mit.edu	37	21	46101961	46101961	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46101961G>A	ENST00000391617.1	-	1	117	c.78C>T	c.(76-78)atC>atT	p.I26I	TSPEAR_ENST00000323084.4_Intron	NM_181686.1	NP_859014.1	P59990	KR121_HUMAN	keratin associated protein 12-1	26	14 X 5 AA approximate repeats.					keratin filament				kidney(1)|large_intestine(1)|lung(1)|skin(2)	5						AGCCCACGGGGATGTAACAGG	0.667000													8	95					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43773519	43773519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43773519G>A	ENST00000372476.3	+	7	1045	c.966G>A	c.(964-966)caG>caA	p.Q322Q	TIE1_ENST00000441333.2_Intron|TIE1_ENST00000538015.1_Silent_p.Q322Q|TIE1_ENST00000433781.2_Intron	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	322	EGF-like 3.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCAGTGTCAGAATGGTGGCA	0.547000													21	57					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039417	31039417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:31039417C>T	ENST00000355537.3	+	4	3038	c.2891C>T	c.(2890-2892)tCc>tTc	p.S964F		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	964					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGCAAGTCCTCCCAGAGGAAG	0.582000													31	161					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29432720	29432720	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29432720G>A	ENST00000389048.3	-	25	4674	c.3768C>T	c.(3766-3768)ctC>ctT	p.L1256L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1256	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GACAGGTCAAGAGGCAGTTTC	0.507000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				16	44					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043470	20043470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20043470G>A	ENST00000570682.1	-	2	949	c.649C>T	c.(649-651)Cgt>Tgt	p.R217C		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	217						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						CCACGGAGACGAAAATTGCTC	0.507000													21	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179497989	179497989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179497989G>A	ENST00000589042.1	-	233	43235	c.43011C>T	c.(43009-43011)caC>caT	p.H14337H	TTN_ENST00000342992.6_Silent_p.H11769H|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Silent_p.H5272H|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.H5464H|TTN_ENST00000359218.5_Silent_p.H5397H|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.H12696H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12696							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATTTCAAAGTGGGCTGTTT	0.413000													49	79					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107868959	107868959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107868959C>T	ENST00000328300.6	+	35	3285	c.3041C>T	c.(3040-3042)cCt>cTt	p.P1014L	COL4A5_ENST00000361603.2_Missense_Mutation_p.P1014L	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1014	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CCTGGTCTCCCTGGACAGCCA	0.433000									Alport syndrome with Diffuse Leiomyomatosis				6	18					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85436463	85436463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:85436463G>A	ENST00000359152.5	-	1	2608	c.2609C>T	c.(2608-2610)tCc>tTc	p.S870F	SYTL2_ENST00000528231.1_Intron|SYTL2_ENST00000389960.4_Intron|SYTL2_ENST00000524452.1_Intron|SYTL2_ENST00000527523.1_Intron|SYTL2_ENST00000316356.4_Intron|SYTL2_ENST00000525423.1_Missense_Mutation_p.S346F|SYTL2_ENST00000354566.3_Missense_Mutation_p.S346F	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	0	C2 2.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		GGAAAGCTGGGAAGTTGGATC	0.498000													37	86					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803597	185803597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185803597G>A	ENST00000302277.6	+	4	4068	c.3474G>A	c.(3472-3474)ggG>ggA	p.G1158G		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1158						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTTGTCCTGGGAACCAGCCAA	0.507000													61	132					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31294508	31294508	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:31294508G>A	ENST00000542188.1	-	27	4759	c.4446C>T	c.(4444-4446)tcC>tcT	p.S1482S	TRPM1_ENST00000256552.6_Silent_p.S1465S|TRPM1_ENST00000397795.2_Silent_p.S1443S|RP11-348B17.1_ENST00000561299.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1443					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTCTTCCCCGGGAATAGACGA	0.453000													46	86					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82880378	82880378	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:82880378C>T	ENST00000298281.4	+	8	3453	c.3001C>T	c.(3001-3003)Caa>Taa	p.Q1001*		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	1001	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						CCCTTTAGTCCAACAAGGAGG	0.507000													16	42					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37441019	37441019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37441019G>A	ENST00000374660.1	+	12	1608	c.1509G>A	c.(1507-1509)aaG>aaA	p.K503K	ANKRD30A_ENST00000602533.1_Silent_p.K503K|ANKRD30A_ENST00000361713.1_Silent_p.K503K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	559						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.K503N(1)		NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CCAAACAAAAGGACTATGAAG	0.294000													23	89					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54395001	54395001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54395001C>T	ENST00000263431.3	+	6	885	c.603C>T	c.(601-603)atC>atT	p.I201I	PRKCG_ENST00000542049.1_Silent_p.I88I|PRKCG_ENST00000540413.1_Silent_p.I201I|PRKCG_ENST00000536044.1_Silent_p.I201I	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	201	C2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TGAAGCTCATCCCAGACCCTC	0.527000													41	118					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839493	27839493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27839493G>A	ENST00000356790.2	+	3	315	c.70G>A	c.(70-72)Gat>Aat	p.D24N		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	24										NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AGGGCTGGAAGATTTGATAGA	0.512000													15	23					0	0	1	0	0
SOCS2	8835	broad.mit.edu	37	12	93968856	93968856	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:93968856C>T	ENST00000340600.2	+	3	1096	c.498C>T	c.(496-498)ctC>ctT	p.L166L	SOCS2_ENST00000551556.1_Silent_p.L166L|SOCS2_ENST00000549206.1_Silent_p.L166L|SOCS2_ENST00000549122.1_Silent_p.L166L|SOCS2_ENST00000548537.1_3'UTR|SOCS2_ENST00000536696.2_Silent_p.L166L	NM_001270468.1|NM_001270469.1|NM_001270471.1|NM_003877.4	NP_001257397.1|NP_001257398.1|NP_001257400.1|NP_003868.1	O14508	SOCS2_HUMAN	suppressor of cytokine signaling 2	166	SOCS box.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)	14						TGCAGCATCTCTGTAGGCTCA	0.478000													28	47					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38983185	38983185	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38983185C>T	ENST00000355481.4	+	38	6314	c.6183C>T	c.(6181-6183)agC>agT	p.S2061S	RYR1_ENST00000360985.3_Silent_p.S2061S|RYR1_ENST00000359596.3_Silent_p.S2061S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2061	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCTGGGCAGCCGCCTCATGA	0.542000													9	81					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26849116	26849116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26849116G>A	ENST00000376236.4	+	12	1693	c.1238G>A	c.(1237-1239)gGa>gAa	p.G413E		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	413	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium		p.G413A(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TGGGTCATGGGAATACGGATA	0.498000													20	93					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99551337	99551337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:99551337G>A	ENST00000373034.4	-	6	5060	c.3385C>T	c.(3385-3387)Ctg>Ttg	p.L1129L	PCDH19_ENST00000255531.7_Silent_p.L1082L|PCDH19_ENST00000420881.2_Silent_p.L1081L	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	1129					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CCTTCCTTCAGAATGGGGCTG	0.512000													60	50					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113533736	113533736	+	Missense_Mutation	SNP	G	G	A	rs140847408		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113533736G>A	ENST00000505019.1	-	7	2736	c.2611C>T	c.(2611-2613)Cca>Tca	p.P871S	C4orf21_ENST00000309071.5_Missense_Mutation_p.P871S|C4orf21_ENST00000445203.2_Missense_Mutation_p.P840S	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	871										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GTAATAAATGGTTTCCTCACT	0.284000													8	55					0	0	1	0	0
IFNA7	3444	broad.mit.edu	37	9	21201647	21201647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21201647C>T	ENST00000239347.3	-	1	557	c.518G>A	c.(517-519)aGa>aAa	p.R173K		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	173					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGAGAAGGATCTCATGATTTC	0.388000													153	244					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131375669	131375669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131375669C>T	ENST00000372739.3	+	40	5163	c.5053C>T	c.(5053-5055)Ctg>Ttg	p.L1685L	SPTAN1_ENST00000372731.4_Silent_p.L1680L|SPTAN1_ENST00000358161.5_Silent_p.L1685L	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1680					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GGTGGAGGCCCTGCTGGCATC	0.478000													15	57					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1808290	1808290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1808290C>T	ENST00000518288.1	+	5	656	c.493C>T	c.(493-495)Ctc>Ttc	p.L165F	ARHGEF10_ENST00000398560.1_Missense_Mutation_p.L165F|ARHGEF10_ENST00000262112.6_Missense_Mutation_p.L165F|ARHGEF10_ENST00000520359.1_Missense_Mutation_p.L141F|ARHGEF10_ENST00000398564.1_Missense_Mutation_p.L165F|ARHGEF10_ENST00000349830.3_Missense_Mutation_p.L141F			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	165					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CAACCTGCCCCTCCTGCTGCC	0.662000													27	51					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15890615	15890615	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15890615G>A	ENST00000587443.2	-	0	182					NR_033864.1																						ATAGGTCCAGGCCAGGAAGCC	0.627000													13	46					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116241795	116241795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116241795C>T	ENST00000374140.2	+	5	649	c.440C>T	c.(439-441)gCc>gTc	p.A147V	RGS3_ENST00000350696.5_Missense_Mutation_p.A147V|RGS3_ENST00000317613.6_Missense_Mutation_p.A35V	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	147	C2.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						TCCATTGATGCCCAGGACCGG	0.577000													43	129					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120387522	120387522	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120387522C>T	ENST00000602047.1	+	18	1976	c.864C>T	c.(862-864)ttC>ttT	p.F288F	PCDP1_ENST00000413369.3_Silent_p.F574F			Q4G0U5	PCDP1_HUMAN		574						cilium	calmodulin binding					Colorectal(110;0.196)					ATTCCTTCTTCAATCTGCAGG	0.333000													25	47					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1032042	1032042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1032042C>T	ENST00000421673.2	-	3	177	c.127G>A	c.(127-129)Ggc>Agc	p.G43S		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	43					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAGCACTGGCCTTTGTCCGGG	0.637000													9	28					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96053752	96053752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:96053752C>T	ENST00000358812.4	+	5	994	c.860C>T	c.(859-861)tCt>tTt	p.S287F	MANEA_ENST00000474553.1_3'UTR	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	287	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		ACCTCAGGGTCTCGGAGTATT	0.383000													25	43					0	0	1	0	0
EFNA4	1945	broad.mit.edu	37	1	155041536	155041536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155041536C>T	ENST00000427683.2	+	4	574	c.511C>T	c.(511-513)Cct>Tct	p.P171S	EFNA4_ENST00000368409.3_3'UTR|EFNA4_ENST00000359751.4_Silent_p.S177S|EFNA3_ENST00000556931.1_Intron|EFNA3_ENST00000505139.1_Intron					ephrin-A4											breast(1)|endometrium(1)|large_intestine(1)|ovary(1)	4	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			AGGAGGGATCCCTGCTGCCTG	0.577000													6	112					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54395847	54395847	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54395847G>A	ENST00000263431.3	+	7	1053	c.771G>A	c.(769-771)ggG>ggA	p.G257G	PRKCG_ENST00000542049.1_Silent_p.G144G|PRKCG_ENST00000540413.1_Silent_p.G257G|PRKCG_ENST00000536044.1_Silent_p.G257G	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	257	C2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACTTCATGGGGGCCATGTCCT	0.657000													6	23					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17435792	17435792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17435792G>A	ENST00000159087.4	-	17	3223	c.3065C>T	c.(3064-3066)cCt>cTt	p.P1022L		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	1022						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						GAGGAAGGCAGGCAGGCGGGT	0.672000													59	140					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123145750	123145750	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123145750C>T	ENST00000264501.4	+	23	3084	c.2711C>T	c.(2710-2712)cCt>cTt	p.P904L	KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000388738.3_Missense_Mutation_p.P904L|KIAA1109_ENST00000455637.1_Missense_Mutation_p.P904L			Q2LD37	K1109_HUMAN	KIAA1109	904					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GAAGGTCTTCCTTTGGGAAGC	0.493000													20	48					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15829321	15829321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15829321C>T	ENST00000338282.6	-	26	3514	c.3408G>A	c.(3406-3408)aaG>aaA	p.K1136K	MYH11_ENST00000300036.5_Silent_p.K1136K|MYH11_ENST00000452625.2_Silent_p.K1143K|MYH11_ENST00000396324.3_Silent_p.K1143K|MYH11_ENST00000576790.1_Silent_p.K1136K	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1136					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GCTTTTCAGCCTTGTTCCTGG	0.597000			T	CBFB	AML								47	94					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70260710	70260710	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70260710C>T	ENST00000301843.8	+	6	560	c.354C>T	c.(352-354)gtC>gtT	p.V118V	CTTN_ENST00000346329.3_Silent_p.V118V|CTTN_ENST00000376561.3_Silent_p.V118V	NM_005231.3	NP_005222.2	Q14247	SRC8_HUMAN	cortactin	118						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		TGGACTCGGTCCGTGGCTTCG	0.562000													22	103					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110477422	110477422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110477422C>T	ENST00000378402.5	+	49	8465	c.8361C>T	c.(8359-8361)ggC>ggT	p.G2787G		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2787					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACAAGGCTGGCTTTCGCTGGG	0.398000										HNSCC(38;0.096)			29	52					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1996215	1996215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1996215C>T	ENST00000382722.5	-	7	1164	c.802G>A	c.(802-804)Gag>Aag	p.E268K	CACNA2D4_ENST00000586184.1_Missense_Mutation_p.E268K|CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.E204K|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.E268K|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.E204K	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	268						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		ACTCCATTCTCATCAGGTGTC	0.502000													4	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179395723	179395723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179395723C>T	ENST00000589042.1	-	358	105843	c.105619G>A	c.(105619-105621)Gaa>Aaa	p.E35207K	TTN_ENST00000342992.6_Missense_Mutation_p.E32639K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589355.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E26142K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E26334K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E26267K|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000587944.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E33566K|TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000589434.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	33566							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTTCCCTTCACTGTTTTCT	0.488000													131	291					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115226835	115226835	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115226835C>T	ENST00000369538.3	-	4	666	c.619G>A	c.(619-621)Gag>Aag	p.E207K	AMPD1_ENST00000353928.6_Missense_Mutation_p.E178K|AMPD1_ENST00000520113.2_Missense_Mutation_p.E211K	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	178					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TAGAAGCTCTCATTTGCTACC	0.338000													51	88					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20618815	20618815	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20618815G>A	ENST00000504154.1	+	35	4382	c.4130G>A	c.(4129-4131)gGa>gAa	p.G1377E	SLIT2_ENST00000273739.5_Missense_Mutation_p.G1390E|SLIT2_ENST00000503823.1_Missense_Mutation_p.G1369E|SLIT2_ENST00000503837.1_Missense_Mutation_p.G1373E	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1377					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CCTTGCCTTGGAAATAAGTAA	0.567000													9	59					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383180	22383180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22383180C>T	ENST00000328795.4	+	1	799	c.708C>T	c.(706-708)gcC>gcT	p.A236A	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		AGAACAAGGCCATGTCCACGT	0.502000													33	93					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37120378	37120378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:37120378G>A	ENST00000274258.7	-	49	9369	c.5782C>T	c.(5782-5784)Ccg>Tcg	p.P1928S	C5orf42_ENST00000425232.2_Missense_Mutation_p.P3030S|C5orf42_ENST00000512288.1_5'UTR|C5orf42_ENST00000508244.1_Missense_Mutation_p.P3030S			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	3030										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ATATAACTCGGTTTGGACATA	0.358000													34	58					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212777	62212777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:62212777G>A	ENST00000519846.1	+	3	863	c.391G>A	c.(391-393)Gaa>Aaa	p.E131K	CLVS1_ENST00000518592.1_Intron|CLVS1_ENST00000325897.4_Missense_Mutation_p.E131K|RP11-787D18.1_ENST00000518064.1_RNA			Q8IUQ0	CLVS1_HUMAN	clavesin 1	131	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						CGGGGTGCTGGAAAACCGAGA	0.463000													19	36					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104032266	104032266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104032266G>A	ENST00000374874.3	+	3	607	c.168G>A	c.(166-168)atG>atA	p.M56I	LPPR1_ENST00000395056.2_Missense_Mutation_p.M56I	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		56						integral to membrane	catalytic activity										GAGACTTAATGAAGCCTTACC	0.488000													12	43					0	0	1	0	0
MAP2K6	5608	broad.mit.edu	37	17	67513729	67513729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67513729C>T	ENST00000590474.1	+	4	508	c.221C>T	c.(220-222)cCc>cTc	p.P74L	MAP2K6_ENST00000589647.1_Missense_Mutation_p.P18L	NM_002758.3	NP_002749.2	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	74	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	20	Breast(10;6.05e-10)					CGGCACGTGCCCAGCGGGCAG	0.507000													14	33					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94913333	94913333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94913333C>T	ENST00000289495.5	+	15	3396	c.3180C>T	c.(3178-3180)atC>atT	p.I1060I	PPP1R9A_ENST00000340694.4_Intron|PPP1R9A_ENST00000424654.1_Silent_p.I1078I|PPP1R9A_ENST00000456331.2_Silent_p.I1078I|PPP1R9A_ENST00000433881.1_Intron|PPP1R9A_ENST00000433360.1_Silent_p.I1100I	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	844	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAACAGGATCTTCAGAGGCA	0.438000										HNSCC(28;0.073)			21	30					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95107644	95107644	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95107644G>A	ENST00000469935.1	+	0	249					NR_015340.1																						TCAGACCAAGGACCCCAGAGG	0.542000													7	20					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1213673	1213673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1213673C>T	ENST00000304460.10	+	5	815	c.759C>T	c.(757-759)ttC>ttT	p.F253F		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	253					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.F253L(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCATCGTCTTCCTCTTCACGC	0.652000													15	21					0	0	1	0	0
ZNF100	163227	broad.mit.edu	37	19	21909553	21909553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21909553C>T	ENST00000358296.6	-	5	1759	c.1561G>A	c.(1561-1563)Gac>Aac	p.D521N	ZNF100_ENST00000305570.6_Missense_Mutation_p.D457N	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						TGGTTAAAGTCTTTACCACAT	0.373000													17	98					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100123421	100123421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100123421C>T	ENST00000330710.5	+	3	1085	c.987C>T	c.(985-987)ttC>ttT	p.F329F	HHIPL1_ENST00000357223.2_Silent_p.F329F	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	329					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				TCTACATCTTCACTGGAGATG	0.507000													147	357					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70982076	70982076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70982076C>T	ENST00000276594.2	-	2	221	c.20G>A	c.(19-21)aGt>aAt	p.S7N		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CACGGCCTCACTTGGCCGGGG	0.687000													3	8					0	0	1	0	0
SDR9C7	121214	broad.mit.edu	37	12	57324024	57324024	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57324024G>A	ENST00000293502.1	-	2	689	c.546C>T	c.(544-546)ttC>ttT	p.F182F		NM_148897.2	NP_683695.1	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C, member 7	182						cytoplasm	binding|oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|pancreas(1)	7						TGCTGTCAGAGAAGGCCTCAA	0.552000													37	101					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15276853	15276853	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15276853C>T	ENST00000263388.2	-	30	5487	c.5412G>A	c.(5410-5412)gaG>gaA	p.E1804E		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1804					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TTGGCATTGGCTCCAGAGCCC	0.577000													22	48					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48372493	48372493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48372493G>A	ENST00000380518.3	-	42	2946	c.2782C>T	c.(2782-2784)Ccc>Tcc	p.P928S	COL2A1_ENST00000337299.6_Missense_Mutation_p.P859S|COL2A1_ENST00000493991.1_5'UTR	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	928	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GCACCTTTGGGACCATCTTTT	0.627000													12	40					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103900460	103900460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103900460C>T	ENST00000278070.2	+	5	2234	c.2195C>T	c.(2194-2196)tCt>tTt	p.S732F	PPRC1_ENST00000413464.2_Missense_Mutation_p.S732F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	732					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTTGTGGATTCTCTGAAAATT	0.547000													48	105					0	0	1	0	0
PCYT1B	9468	broad.mit.edu	37	X	24608226	24608226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:24608226C>T	ENST00000379145.1	-	4	390	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	PCYT1B_ENST00000356768.4_Missense_Mutation_p.E134K|PCYT1B_ENST00000492876.1_5'UTR|PCYT1B_ENST00000379144.2_Missense_Mutation_p.E134K	NM_001163264.1	NP_001156736.1	Q9Y5K3	PCY1B_HUMAN	phosphate cytidylyltransferase 1, choline, beta	134	Catalytic (Potential).					endoplasmic reticulum	choline-phosphate cytidylyltransferase activity			breast(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	17					Choline(DB00122)	CTGAGAGCTTCGTATCTCTCG	0.443000													23	14					0	0	1	0	0
PHF13	148479	broad.mit.edu	37	1	6681627	6681627	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6681627G>A	ENST00000377648.4	+	4	1215	c.833G>A	c.(832-834)cGg>cAg	p.R278Q	PHF13_ENST00000495385.1_Intron	NM_153812.2	NP_722519.2	Q86YI8	PHF13_HUMAN	PHD finger protein 13	278					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(3)	7	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		CAAAAGTGCCGGGACTCCAAG	0.577000													19	61					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756742	56756742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56756742G>A	ENST00000326855.2	+	1	396	c.354G>A	c.(352-354)atG>atA	p.M118I		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						TGGCTATGATGGCAGTGGATC	0.418000													50	82					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033749	82033749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82033749C>T	ENST00000328945.5	-	3	276	c.149G>A	c.(148-150)gGa>gAa	p.G50E	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	50					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						AAACTTGATTCCTTCTGGAAT	0.463000													39	138					0	0	1	0	0
CPLX3	594855	broad.mit.edu	37	15	75122545	75122545	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75122545C>T	ENST00000395018.4	+	3	484	c.327C>T	c.(325-327)atC>atT	p.I109I	RP11-414J4.2_ENST00000564823.1_RNA	NM_001030005.2	NP_001025176.1	Q8WVH0	CPLX3_HUMAN	complexin 3	109						cell junction|synapse	syntaxin binding			large_intestine(2)|lung(2)	4						CCAAGATGATCGAGGAGGACA	0.617000													17	97					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	146997584	146997584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:146997584C>T	ENST00000265272.5	-	19	2703	c.2236G>A	c.(2236-2238)Gag>Aag	p.E746K	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.E704K|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.E725K	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	746						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCTCAGCTCCTCTTGCTGT	0.433000													24	83					0	0	1	0	0
TLK1	9874	broad.mit.edu	37	2	171871371	171871371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171871371C>T	ENST00000442919.2	-	13	1795	c.1180G>A	c.(1180-1182)Gat>Aat	p.D394N	TLK1_ENST00000521943.1_Missense_Mutation_p.D394N|TLK1_ENST00000434911.2_Missense_Mutation_p.D346N|TLK1_ENST00000360843.3_Missense_Mutation_p.D463N|TLK1_ENST00000431350.2_Missense_Mutation_p.D442N	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1	442					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TGTGAATTATCTTCATTGTTT	0.368000													29	89					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537744	55537744	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55537744C>T	ENST00000220676.1	+	4	1450	c.1302C>T	c.(1300-1302)atC>atT	p.I434I		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	434					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACACAGATATCATCCAGGGAA	0.448000													32	78					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594181	179594181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179594181C>T	ENST00000589042.1	-	64	18926	c.18702G>A	c.(18700-18702)aaG>aaA	p.K6234K	TTN_ENST00000342992.6_Silent_p.K4990K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.K5917K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5917	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTGTTATTCTTCAGCCAAG	0.453000													50	85					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74700994	74700994	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74700994G>A	ENST00000373032.3	-	3	491	c.399C>T	c.(397-399)ttC>ttT	p.F133F		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	133					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					GACACCATCGGAATTTTGCAT	0.502000													41	158					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50794294	50794294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50794294C>T	ENST00000440075.2	+	36	5163	c.5116C>T	c.(5116-5118)Cgc>Tgc	p.R1706C	MYH14_ENST00000425460.1_Missense_Mutation_p.R1673C|MYH14_ENST00000376970.2_Missense_Mutation_p.R1698C|MYH14_ENST00000598205.1_Missense_Mutation_p.R1673C|MYH14_ENST00000596571.1_Missense_Mutation_p.R1665C|MYH14_ENST00000262269.8_Missense_Mutation_p.R1706C|MYH14_ENST00000601313.1_Missense_Mutation_p.R1706C			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1665					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GAAGCAGCTTCGCAAGATGCA	0.642000													11	13					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55047106	55047106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55047106C>T	ENST00000335056.3	+	4	689	c.651C>T	c.(649-651)atC>atT	p.I217I	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		ACATTGTGATCACAGGTGAGT	0.527000													28	103					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93982115	93982115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:93982115C>T	ENST00000369303.4	-	6	1534	c.1350G>A	c.(1348-1350)atG>atA	p.M450I		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	450	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTCTCTCCTTCATTACTCCAC	0.438000													57	56					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26692881	26692881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26692881G>A	ENST00000529632.2	+	4	1193	c.997G>A	c.(997-999)Gaa>Aaa	p.E333K	SEZ6L_ENST00000343706.4_Missense_Mutation_p.E333K|SEZ6L_ENST00000360929.3_Missense_Mutation_p.E333K|SEZ6L_ENST00000404234.3_Missense_Mutation_p.E333K|SEZ6L_ENST00000248933.6_Missense_Mutation_p.E333K|SEZ6L_ENST00000402979.1_Missense_Mutation_p.E106K|SEZ6L_ENST00000403121.1_Missense_Mutation_p.E106K	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	333	CUB 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GTCCGATGGGGAACTGCTCTC	0.582000													11	24					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1653404	1653404	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1653404G>A	ENST00000252804.4	-	17	2198	c.2148C>T	c.(2146-2148)ctC>ctT	p.L716L		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	716					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GGTTTGCGATGAGGTTCAGGT	0.582000													10	86					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	424297	424297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:424297G>A	ENST00000256509.2	+	18	2761	c.2119G>A	c.(2119-2121)Gaa>Aaa	p.E707K	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Missense_Mutation_p.E691K	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	691					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGCCGTGAACGAAGTAGGGAG	0.463000													28	45					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537337	5537337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5537337G>A	ENST00000380184.1	-	1	598	c.335C>T	c.(334-336)tCc>tTc	p.S112F	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	112										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GTCCCGGAAGGAATGGGCTAG	0.537000													19	70					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457509	110457509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110457509C>T	ENST00000378402.5	+	38	5515	c.5411C>T	c.(5410-5412)cCt>cTt	p.P1804L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1804	IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTTGTGACTCCTCTCCCAGTT	0.463000										HNSCC(38;0.096)			31	81					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179414324	179414324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179414324C>T	ENST00000589042.1	-	338	92349	c.92125G>A	c.(92125-92127)Gat>Aat	p.D30709N	TTN_ENST00000342992.6_Missense_Mutation_p.D28141N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D21644N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D21836N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D21769N|RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D29068N|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29068	Ig-like 138.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCACTGGATCAGAATCAAGT	0.373000													25	99					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113303252	113303252	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113303252G>A	ENST00000389385.4	+	6	761	c.264G>A	c.(262-264)aaG>aaA	p.K88K	RPH3A_ENST00000551052.1_Silent_p.K84K|RPH3A_ENST00000548866.1_Silent_p.K39K|RPH3A_ENST00000420983.2_Silent_p.K88K|RPH3A_ENST00000447659.2_Silent_p.K39K|RPH3A_ENST00000543106.2_Silent_p.K88K|RPH3A_ENST00000415485.3_Silent_p.K88K	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	88	RabBD.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ACATGAGGAAGAACGTGGCTG	0.537000													7	107					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105417287	105417287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105417287G>A	ENST00000333244.5	-	7	4620	c.4501C>T	c.(4501-4503)Ccg>Tcg	p.P1501S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1501						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCGAACGACGGCATCTTGAAC	0.602000													45	289					0	0	1	0	0
IL34	146433	broad.mit.edu	37	16	70693520	70693520	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70693520G>A	ENST00000429149.2	+	6	957		c.e6-1		IL34_ENST00000288098.2_Splice_Site|IL34_ENST00000566361.1_Splice_Site	NM_001172771.1|NM_152456.2	NP_001166242.1|NP_689669.2	Q6ZMJ4	IL34_HUMAN	interleukin 34						positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			breast(1)|central_nervous_system(1)|kidney(9)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(2)	17						CTCCTTTCCAGGATGTGGAGG	0.627000													8	26					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76521136	76521136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76521136G>A	ENST00000389840.5	-	25	3931	c.3807C>T	c.(3805-3807)caC>caT	p.H1269H	DNAH17_ENST00000585328.1_Silent_p.H1270H					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGACCTCCCGGTGGCAGGCCT	0.657000													14	55					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67406248	67406248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:67406248G>A	ENST00000382713.5	+	6	837	c.647G>A	c.(646-648)gGa>gAa	p.G216E	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	216	IRS-type PTB.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				ACAAGGGAAGGAGAAATGATC	0.443000													45	123					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50056163	50056163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50056163C>T	ENST00000281631.5	+	5	470	c.312C>T	c.(310-312)tcC>tcT	p.S104S	PARP8_ENST00000511363.2_Intron|PARP8_ENST00000505697.2_Silent_p.S104S|PARP8_ENST00000503750.2_Silent_p.S104S|PARP8_ENST00000505554.1_Silent_p.S83S|PARP8_ENST00000514067.2_Silent_p.S104S|PARP8_ENST00000514342.2_5'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	104						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				GTTGCTTATCCATAAAATCCA	0.234000													8	44					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129209148	129209148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129209148C>T	ENST00000280333.6	+	43	4434	c.4325C>T	c.(4324-4326)cCa>cTa	p.P1442L		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1442	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TATTCTCGGCCAATCCGGAAG	0.408000													11	29					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33985438	33985438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33985438G>A	ENST00000373381.4	-	69	10886	c.10710C>T	c.(10708-10710)ggC>ggT	p.G3570G		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3426						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGAGCACGAAGCCCGCAATAA	0.627000													15	53					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57335885	57335885	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57335885G>A	ENST00000326441.9	-	4	502	c.139C>T	c.(139-141)Cag>Tag	p.Q47*	PEG3_ENST00000594706.1_Intron|PEG3_ENST00000423103.2_Nonsense_Mutation_p.Q47*|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Intron|PEG3_ENST00000598410.1_Intron|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	47	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CGAAACCTCTGATGAAAAAAC	0.502000													13	56					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2842728	2842728	+	Silent	SNP	C	C	T	rs141872607		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2842728C>T	ENST00000380445.3	+	11	1095	c.1023C>T	c.(1021-1023)gcC>gcT	p.A341A	VPS16_ENST00000481812.2_Intron|VPS16_ENST00000380469.3_Intron	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	341					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome		p.A341A(1)		NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						TCAAAATTGCCTCAATGGCCC	0.597000													13	18					0	0	1	0	0
CD81	975	broad.mit.edu	37	11	2416230	2416230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2416230C>T	ENST00000263645.5	+	4	564	c.308C>T	c.(307-309)gCc>gTc	p.A103V	CD81_ENST00000524805.1_3'UTR|CD81_ENST00000492627.1_Missense_Mutation_p.A32V|CD81_ENST00000526072.1_Missense_Mutation_p.A32V|CD81_ENST00000481687.1_Missense_Mutation_p.A109V|CD81_ENST00000381036.3_Missense_Mutation_p.A141V	NM_004356.3	NP_004347.1	P60033	CD81_HUMAN	CD81 molecule	103					activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding			endometrium(1)|lung(3)|skin(1)	5		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		ATCCTGTTTGCCTGTGAGGTG	0.662000													33	60					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091567	9091567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9091567G>A	ENST00000397910.4	-	1	451	c.248C>T	c.(247-249)tCc>tTc	p.S83F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	83	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGAGCAGAGGACATCACCCC	0.532000													32	87					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61255990	61255990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61255990C>T	ENST00000344731.5	+	2	191	c.89C>T	c.(88-90)tCc>tTc	p.S30F	SERPINB13_ENST00000269489.5_Missense_Mutation_p.S30F	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	30					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						ATCTTCTTTTCCCCTGTGGGC	0.532000													15	56					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15880873	15880873	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15880873C>T	ENST00000595525.1	+	0	529				CYP4F24P_ENST00000587443.2_RNA																							CTCTGAAGGTCCGATCTTCTT	0.493000													4	14					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11189841	11189841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11189841G>A	ENST00000361445.4	-	40	5744	c.5668C>T	c.(5668-5670)Cgt>Tgt	p.R1890C	MTOR_ENST00000376838.1_Missense_Mutation_p.R95C	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1890	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GAGATGGAACGGAAGAAGCCC	0.522000													10	55					0	0	1	0	0
DGKE	8526	broad.mit.edu	37	17	54925355	54925355	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54925355C>T	ENST00000284061.3	+	5	997	c.817C>T	c.(817-819)Cga>Tga	p.R273*		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	273	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					TTATTCAGCTCGAGTACTTGT	0.388000													22	77					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99358502	99358502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99358502C>T	ENST00000354593.2	-	7	1009	c.906G>A	c.(904-906)atG>atA	p.M302I	CYP3A4_ENST00000336411.2_Missense_Mutation_p.M452I			P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	452					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	GAGCAAGTTTCATGTTCATGA	0.363000													65	147					0	0	1	0	0
REEP2	51308	broad.mit.edu	37	5	137780194	137780194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137780194C>T	ENST00000378339.2	+	4	465	c.273C>T	c.(271-273)ttC>ttT	p.F91F	REEP2_ENST00000254901.5_Silent_p.F91F|REEP2_ENST00000506158.1_Silent_p.F53F	NM_001271803.1	NP_001258732.1	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	91						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACCGCAAGTTCGTGCACCCAA	0.587000													16	59					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242755876	242755876	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242755876C>T	ENST00000391969.2	+	3	906	c.195C>T	c.(193-195)tcC>tcT	p.S65S	NEU4_ENST00000405370.1_Silent_p.S65S|NEU4_ENST00000404257.1_Silent_p.S77S|NEU4_ENST00000325935.6_Silent_p.S78S|NEU4_ENST00000407683.1_Silent_p.S65S	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	65						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CCGGGGGCTCCGTGCGGGTGA	0.746000													3	6					0	0	1	0	0
LEPREL4	10609	broad.mit.edu	37	17	39964117	39964117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39964117G>A	ENST00000355468.3	-	6	1522	c.1056C>T	c.(1054-1056)ccC>ccT	p.P352P	LEPREL4_ENST00000393928.1_Silent_p.P352P			Q92791	SC65_HUMAN	leprecan-like 4	352	Asp/Glu-rich (acidic).				synaptonemal complex assembly	nucleolus|synaptonemal complex	binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8						CCACCTCCCGGGGCTGGAAGT	0.597000													26	20					0	0	1	0	0
HORMAD2	150280	broad.mit.edu	37	22	30489904	30489904	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30489904G>A	ENST00000336726.6	+	2	318		c.e2-1		HORMAD2_ENST00000403975.1_Splice_Site	NM_152510.2	NP_689723.1	Q8N7B1	HORM2_HUMAN	HORMA domain containing 2						meiosis|mitosis	chromosome|nucleus				large_intestine(1)|lung(1)	2			Epithelial(10;0.125)			ttttttaataGGTTGGACTTG	0.338000													8	10					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103343647	103343647	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103343647G>A	ENST00000358392.2	-	67	5702	c.5385C>T	c.(5383-5385)gtC>gtT	p.V1795V	COL11A1_ENST00000370096.3_Silent_p.V1783V|COL11A1_ENST00000512756.1_Silent_p.V1667V|COL11A1_ENST00000353414.4_Silent_p.V1744V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1783	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CATTGATCATGACATCAACAA	0.323000													35	62					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10088351	10088351	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10088351C>T	ENST00000287647.3	+	15	1315	c.1222C>T	c.(1222-1224)Cga>Tga	p.R408*	FANCD2_ENST00000383806.1_Nonsense_Mutation_p.R408*|FANCD2_ENST00000383807.1_Nonsense_Mutation_p.R408*|FANCD2_ENST00000419585.1_Nonsense_Mutation_p.R408*	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	408					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AAATAAGATTCGATCAGGCTG	0.368000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				25	116					0	0	1	0	0
CHST14	113189	broad.mit.edu	37	15	40764056	40764056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40764056C>T	ENST00000306243.5	+	1	897	c.644C>T	c.(643-645)cCc>cTc	p.P215L	CHST14_ENST00000559991.1_Missense_Mutation_p.P190L	NM_130468.3	NP_569735.1	Q8NCH0	CHSTE_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	215					carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding			cervix(1)|large_intestine(1)|prostate(2)	4		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		GTGCGGGAGCCCTTGGAACGC	0.592000													29	104					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234460143	234460143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234460143G>A	ENST00000251722.6	-	7	833	c.716C>T	c.(715-717)cCt>cTt	p.P239L	USP40_ENST00000450966.1_Missense_Mutation_p.P251L|USP40_ENST00000427112.2_Missense_Mutation_p.P239L			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	239					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		AAGAAAAGGAGGCAGCTTACG	0.318000													4	12					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	35993773	35993773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35993773G>A	ENST00000339686.3	-	10	1326	c.1150C>T	c.(1150-1152)Ccc>Tcc	p.P384S	DMKN_ENST00000492341.2_Missense_Mutation_p.P31S|DMKN_ENST00000429837.1_Missense_Mutation_p.P343S|DMKN_ENST00000480502.1_Intron|DMKN_ENST00000414866.2_Missense_Mutation_p.P97S|DMKN_ENST00000419602.1_Missense_Mutation_p.P373S|DMKN_ENST00000602781.1_Missense_Mutation_p.P97S|DMKN_ENST00000402589.2_Missense_Mutation_p.P97S|DMKN_ENST00000443640.1_Missense_Mutation_p.P147S|DMKN_ENST00000436012.1_Missense_Mutation_p.P80S|DMKN_ENST00000467637.1_Missense_Mutation_p.P109S|DMKN_ENST00000472252.2_Missense_Mutation_p.P31S|DMKN_ENST00000462126.1_5'UTR	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	384						extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGGGTGCTGGGGGGCGGGACC	0.622000													18	44					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50220340	50220340	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50220340G>A	ENST00000002829.3	+	10	1391	c.907G>A	c.(907-909)Gat>Aat	p.D303N	SEMA3F_ENST00000434342.1_Missense_Mutation_p.D272N|SEMA3F_ENST00000413852.1_Missense_Mutation_p.D204N	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	303	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CCCCCAGAACGATGACGGTGG	0.617000													5	21					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980866	40980866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40980866C>T	ENST00000373198.3	-	10	1855	c.1620G>A	c.(1618-1620)ggG>ggA	p.G540G	PTPRT_ENST00000373193.3_Silent_p.G540G|PTPRT_ENST00000373184.1_Silent_p.G540G|PTPRT_ENST00000373201.1_Silent_p.G540G|PTPRT_ENST00000373190.1_Silent_p.G540G|PTPRT_ENST00000373187.1_Silent_p.G540G|PTPRT_ENST00000356100.2_Silent_p.G540G	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	540	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGAACACTTTCCCCCTCTGGC	0.527000													29	90					0	0	1	0	0
FOXRED2	80020	broad.mit.edu	37	22	36900680	36900680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36900680G>A	ENST00000397224.4	-	3	754	c.661C>T	c.(661-663)Cgt>Tgt	p.R221C	FOXRED2_ENST00000216187.6_Missense_Mutation_p.R221C|FOXRED2_ENST00000397223.4_Missense_Mutation_p.R221C	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	221					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GAGTTCCCACGACCCAGGATC	0.567000													18	45					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45224880	45224880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45224880G>A	ENST00000279027.4	-	5	728	c.710C>T	c.(709-711)tCc>tTc	p.S237F	SLC13A3_ENST00000495082.1_Missense_Mutation_p.S190F|SLC13A3_ENST00000435032.1_5'UTR|SLC13A3_ENST00000290317.5_Missense_Mutation_p.S190F|SLC13A3_ENST00000396360.1_Missense_Mutation_p.S190F|SLC13A3_ENST00000372121.1_Missense_Mutation_p.P215S|SLC13A3_ENST00000472148.1_Missense_Mutation_p.S190F|SLC13A3_ENST00000413164.2_Missense_Mutation_p.P215S	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	237						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	GTAGGGGATGGAGATGAGGAA	0.577000													35	93					0	0	1	0	0
TMEM8A	58986	broad.mit.edu	37	16	427062	427062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:427062G>A	ENST00000431232.2	-	4	770	c.610C>T	c.(610-612)Ctc>Ttc	p.L204F	TMEM8A_ENST00000250930.3_Missense_Mutation_p.L11F	NM_021259.2	NP_067082.2	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A	204					cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						TGGGAGAGGAGGGTCTGAGGA	0.657000											OREG0003703	type=REGULATORY REGION|Gene=TMEM8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	47					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106680917	106680917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:106680917G>A	ENST00000526355.1	-	5	1962	c.1494C>T	c.(1492-1494)ttC>ttT	p.F498F	GUCY1A2_ENST00000282249.2_Silent_p.F498F|GUCY1A2_ENST00000347596.2_Silent_p.F519F	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	498					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		CATCACCAGGGAAAATAGAAT	0.418000													20	77					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7584837	7584837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7584837G>A	ENST00000379802.3	+	24	7683	c.7342G>A	c.(7342-7344)Gaa>Aaa	p.E2448K	DSP_ENST00000418664.2_Missense_Mutation_p.E1849K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2448	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCCTCTGAAAGAAAAGAAGAA	0.403000													38	87					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890592	229890592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:229890592G>A	ENST00000392054.3	-	4	842	c.503C>T	c.(502-504)aCc>aTc	p.T168I	PID1_ENST00000354069.6_Missense_Mutation_p.T170I|PID1_ENST00000392055.3_Missense_Mutation_p.T137I|PID1_ENST00000409462.1_Missense_Mutation_p.T88I|PID1_ENST00000482518.2_Intron	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	170	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GTGGTCGGCGGTGCAGTAGGC	0.587000													39	84					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11319416	11319416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11319416G>A	ENST00000294618.7	-	39	5045	c.5034C>T	c.(5032-5034)ttC>ttT	p.F1678F	CTC-510F12.2_ENST00000588634.1_RNA|DOCK6_ENST00000319867.7_Silent_p.F1017F	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1678	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CCAGCTCAGTGAAGTGCTTCC	0.642000													18	44					0	0	1	0	0
TRAT1	50852	broad.mit.edu	37	3	108541781	108541781	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108541781G>A	ENST00000295756.6	+	1	237	c.7_splice	c.e1+1	p.G3_splice	TRAT1_ENST00000493604.1_3'UTR|TRAT1_ENST00000426646.1_Splice_Site_p.D3_splice	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	3					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						AAGCATGTCAGGTAAGTGGCA	0.313000													39	128					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31405603	31405603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31405603G>A	ENST00000389202.2	+	2	127	c.78G>A	c.(76-78)acG>acA	p.T26T		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	26					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						AGGAGCCTACGATCTTCCAGG	0.572000													16	48					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220161176	220161176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220161176G>A	ENST00000295718.2	-	17	2613	c.2373C>T	c.(2371-2373)atC>atT	p.I791I	PTPRN_ENST00000497977.1_5'UTR|PTPRN_ENST00000423636.2_Silent_p.I701I|PTPRN_ENST00000409251.3_Silent_p.I762I	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	791	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		AGAAGTCTGCGATGGTATGGG	0.602000													31	78					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99506319	99506319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99506319C>T	ENST00000355947.2	-	4	813	c.684G>A	c.(682-684)acG>acA	p.T228T	TRIM4_ENST00000354241.5_Silent_p.T202T|TRIM4_ENST00000349062.2_Silent_p.T202T	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	228					protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				GCTTCTTCTTCGTCTCTTCTT	0.448000													37	115					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24436904	24436904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24436904C>T	ENST00000230036.1	-	22	2368	c.2258G>A	c.(2257-2259)gGa>gAa	p.G753E		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	753						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						GCCGTCTTCTCCCCCAATCAG	0.443000													28	74					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49823408	49823408	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49823408C>T	ENST00000561648.1	-	2	119	c.66G>A	c.(64-66)gtG>gtA	p.V22V	ZNF423_ENST00000563137.2_5'UTR|ZNF423_ENST00000562520.1_5'UTR|ZNF423_ENST00000262383.2_Silent_p.V22V	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	22					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CTGCTGCTGTCACGGAGGAAT	0.572000													5	54					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740411	140740411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140740411G>A	ENST00000522605.1	+	1	709	c.709G>A	c.(709-711)Gat>Aat	p.D237N	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATGCCAACGATAACCCTCC	0.567000													24	61					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394955	154394955	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154394955C>T	ENST00000435029.4	+	1	1696	c.1536C>T	c.(1534-1536)acC>acT	p.T512T		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	512					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACGCTTTTACCACTCAGCATG	0.488000													30	78					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848098	215848098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215848098C>T	ENST00000366943.2	-	63	13541	c.13155G>A	c.(13153-13155)aaG>aaA	p.K4385K	USH2A_ENST00000307340.3_Silent_p.K4385K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4385	Fibronectin type-III 29.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTTAGTAATCTTTCCATTTT	0.478000										HNSCC(13;0.011)			7	71					0	0	1	0	0
CCND2	894	broad.mit.edu	37	12	4387925	4387925	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4387925G>A	ENST00000261254.3	+	3	680		c.e3-1			NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2						cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			TTCCCCTCCAGGAGTGGGAAC	0.572000			T	IGL@	"""NHL,CLL"""								10	79					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3675458	3675458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3675458C>T	ENST00000344754.4	-	11	2795	c.2796G>A	c.(2794-2796)cgG>cgA	p.R932R	SIGLEC1_ENST00000202578.4_Silent_p.R932R	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	932	Ig-like C2-type 9.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCTGGCCATCCCGATACCAAC	0.612000													25	58					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4249749	4249749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4249749C>T	ENST00000404826.2	+	38	5633	c.5494C>T	c.(5494-5496)Ctg>Ttg	p.L1832L	SDK1_ENST00000389531.3_Silent_p.L1812L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1832	Fibronectin type-III 12.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAACGGCATCCTGCAGGGCTA	0.667000													10	58					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711073	58711073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58711073G>A	ENST00000300079.5	+	2	132	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_5'UTR	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	agcgcgaagtgaacacggaag	0.453000													9	39					0	0	1	0	0
CLDN23	137075	broad.mit.edu	37	8	8560001	8560001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8560001G>A	ENST00000519106.1	+	1	554	c.93G>A	c.(91-93)cgG>cgA	p.R31R		NM_194284.2	NP_919260.2	Q96B33	CLD23_HUMAN	claudin 23	31					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)	2		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		CCGGCTGGCGGCTGGTGAAGG	0.706000													5	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179571376	179571376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179571376C>T	ENST00000589042.1	-	102	29449	c.29225G>A	c.(29224-29226)gGa>gAa	p.G9742E	TTN_ENST00000342992.6_Missense_Mutation_p.G8498E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G9425E|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9425	Ig-like 78.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACACGACCTCCTTGGTTCAG	0.443000													64	131					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755243	140755243	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140755243G>A	ENST00000517434.1	+	1	1593	c.1593G>A	c.(1591-1593)tgG>tgA	p.W531*	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAGCTGTGGGTGACAGCCA	0.597000													65	228					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57553764	57553764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57553764C>T	ENST00000243077.3	+	12	2421	c.1955C>T	c.(1954-1956)gCt>gTt	p.A652V		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	652					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CACCCCAGGGCTATTGTGGTG	0.562000													12	41					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78784639	78784639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78784639G>A	ENST00000545128.1	+	13	2177	c.1639G>A	c.(1639-1641)Gaa>Aaa	p.E547K	PCSK5_ENST00000376752.4_Missense_Mutation_p.E547K|PCSK5_ENST00000376767.3_Missense_Mutation_p.E547K	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	547	Homo B/P.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TCACTCCATGGAAGGATTCAA	0.413000													27	100					0	0	1	0	0
TNPO3	23534	broad.mit.edu	37	7	128615974	128615974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128615974G>A	ENST00000393245.1	-	17	2552	c.2179C>T	c.(2179-2181)Cac>Tac	p.H727Y	TNPO3_ENST00000471234.1_Missense_Mutation_p.H629Y|TNPO3_ENST00000471166.1_Missense_Mutation_p.H727Y|TNPO3_ENST00000265388.5_Missense_Mutation_p.H693Y|TNPO3_ENST00000482320.1_Missense_Mutation_p.H627Y	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	693					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						TGATGTACGTGGTACACATTC	0.453000													19	49					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60074101	60074101	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:60074101G>A	ENST00000267484.5	-	4	2210	c.1875C>T	c.(1873-1875)gcC>gcT	p.A625A	RTN1_ENST00000395090.1_Silent_p.A42A|RTN1_ENST00000557422.1_5'UTR|RTN1_ENST00000342503.4_Silent_p.A57A	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	625	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GGGCCAGGTAGGCCACGACGC	0.557000													5	53					0	0	1	0	0
RCN1	5954	broad.mit.edu	37	11	32125929	32125929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:32125929G>A	ENST00000054950.3	+	6	1200	c.907G>A	c.(907-909)Gag>Aag	p.E303K	RCN1_ENST00000532942.1_Missense_Mutation_p.E252K|RP1-65P5.3_ENST00000533009.1_RNA	NM_002901.2	NP_002892.1	Q15293	RCN1_HUMAN	reticulocalbin 1, EF-hand calcium binding domain	303	EF-hand 6.					endoplasmic reticulum lumen	calcium ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)	17	Lung SC(675;0.225)					GCTAACTAAAGAGGAAATATT	0.398000													10	19					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14022146	14022146	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:14022146G>A	ENST00000382080.1	-	5	1205	c.490C>T	c.(490-492)Ctg>Ttg	p.L164L	RP11-3G21.1_ENST00000527110.1_RNA|SGCZ_ENST00000421524.2_Silent_p.L117L	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	151					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GCAGAAAACAGCACCCTGCCA	0.408000													10	72					0	0	1	0	0
TMEM63C	57156	broad.mit.edu	37	14	77715711	77715711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77715711G>A	ENST00000298351.4	+	21	2092	c.1948G>A	c.(1948-1950)Gag>Aag	p.E650K		NM_020431.2	NP_065164.2	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	650						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(1)	23			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CAAACTGAACGAGCAGATCCA	0.532000													31	75					0	0	1	0	0
NR1I3	9970	broad.mit.edu	37	1	161205715	161205715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161205715C>T	ENST00000367983.4	-	3	454	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	NR1I3_ENST00000367982.4_Missense_Mutation_p.E54K|NR1I3_ENST00000442691.2_Missense_Mutation_p.E54K|NR1I3_ENST00000508387.1_Missense_Mutation_p.E25K|NR1I3_ENST00000508740.1_Missense_Mutation_p.E25K|NR1I3_ENST00000428574.2_Missense_Mutation_p.E54K|NR1I3_ENST00000504010.1_Missense_Mutation_p.E25K|NR1I3_ENST00000505005.1_Missense_Mutation_p.E54K|NR1I3_ENST00000367984.4_Missense_Mutation_p.E54K|NR1I3_ENST00000367985.3_Missense_Mutation_p.E54K|NR1I3_ENST00000437437.2_Missense_Mutation_p.E25K|NR1I3_ENST00000506209.1_Missense_Mutation_p.E25K|NR1I3_ENST00000502985.1_Missense_Mutation_p.E54K|NR1I3_ENST00000412844.2_Missense_Mutation_p.E25K|NR1I3_ENST00000367979.2_Missense_Mutation_p.E54K|NR1I3_ENST00000512372.1_Missense_Mutation_p.E25K|NR1I3_ENST00000511676.1_Missense_Mutation_p.E25K|NR1I3_ENST00000511944.1_Missense_Mutation_p.E54K|NR1I3_ENST00000511748.1_Missense_Mutation_p.E25K|NR1I3_ENST00000367980.2_Missense_Mutation_p.E54K|NR1I3_ENST00000367981.3_Missense_Mutation_p.E25K|NR1I3_ENST00000515621.1_5'UTR|NR1I3_ENST00000515452.1_Missense_Mutation_p.E54K			Q14994	NR1I3_HUMAN	nuclear receptor subfamily 1, group I, member 3	54					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	15	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TTGCTGACTTCACAGCTTCCA	0.532000													14	65					0	0	1	0	0
MICA	100507436	broad.mit.edu	37	6	31378943	31378943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31378943C>T	ENST00000449934.2	+	3	474	c.420C>T	c.(418-420)ttC>ttT	p.F140F	HCP5_ENST00000414046.2_RNA	NM_001177519.1	NP_001170990.1	Q29983	MICA_HUMAN	MHC class I polypeptide-related sequence A	140					antigen processing and presentation|cytolysis|defense response to bacterium|defense response to virus|gamma-delta T cell activation|immune response to tumor cell|response to DNA damage stimulus|response to heat|stimulatory C-type lectin receptor signaling pathway	cell surface|cytoplasm|extracellular space|integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding	p.F140F(1)		breast(1)|endometrium(3)|kidney(1)	5		Ovarian(999;0.0253)				GGGAGCTCTTCCTCTCCCAAA	0.537000													12	17					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106917009	106917009	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106917009G>A	ENST00000369701.3	+	10	1823	c.1596G>A	c.(1594-1596)gtG>gtA	p.V532V		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	532						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTCCGGATGTGGACCTGAGAG	0.562000													5	57					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10204902	10204902	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10204902C>T	ENST00000418404.3	-	39	5949	c.5786G>A	c.(5785-5787)cGa>cAa	p.R1929Q	MYH13_ENST00000570743.1_Missense_Mutation_p.R1929Q|MYH13_ENST00000252172.4_Missense_Mutation_p.R1929Q			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1929					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GCCCACGTCTCGGCTCTTGGC	0.582000													17	140					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020566	5020566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5020566G>A	ENST00000321543.1	+	1	354	c.354G>A	c.(352-354)ctG>ctA	p.L118L		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGTGTTGCTGGCCATGGCCT	0.498000													65	145					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39394370	39394370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39394370G>A	ENST00000545653.1	-	2	583	c.53C>T	c.(52-54)gCc>gTc	p.A18V	DAB2_ENST00000509337.1_Missense_Mutation_p.A18V|DAB2_ENST00000320816.6_Missense_Mutation_p.A18V|DAB2_ENST00000339788.6_Missense_Mutation_p.A18V	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	18					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			TTTTGGTGCGGCCTGTTGGTC	0.493000													31	59					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2812786	2812786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2812786C>T	ENST00000301740.8	+	11	2806	c.2257C>T	c.(2257-2259)Cgc>Tgc	p.R753C		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	753	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						GAAGAAATCTCGCATTTCTTC	0.488000													37	112					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55127312	55127312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55127312G>A	ENST00000257290.5	+	3	431	c.100G>A	c.(100-102)Gaa>Aaa	p.E34K	FIP1L1_ENST00000507166.1_Intron|PDGFRA_ENST00000508170.1_Missense_Mutation_p.E34K	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	34	Ig-like C2-type 1.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CCTTCCAAATGAAAATGAAAA	0.473000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			32	139					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35477696	35477696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35477696C>T	ENST00000229771.6	-	6	588	c.509G>A	c.(508-510)gGa>gAa	p.G170E	TULP1_ENST00000322263.4_Missense_Mutation_p.G117E	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	170					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						GTCAGGGCTTCCCAGGTCTCC	0.567000													39	106					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581303	140581303	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140581303C>T	ENST00000354757.3	+	1	1956	c.1956C>T	c.(1954-1956)cgC>cgT	p.R652R	PCDHB11_ENST00000536699.1_Silent_p.R287R	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		652	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCCTCCGCGCTCGGCCACCG	0.721000													21	57					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102668758	102668758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102668758C>T	ENST00000315274.6	-	1	133	c.66G>A	c.(64-66)gcG>gcA	p.A22A	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	22					blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		TTTCTAGAGTCGCTGGGAAGC	0.443000													16	27					0	0	1	0	0
FASTKD2	22868	broad.mit.edu	37	2	207636626	207636626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207636626C>T	ENST00000236980.6	+	5	1347	c.999C>T	c.(997-999)gcC>gcT	p.A333A	FASTKD2_ENST00000402774.3_Silent_p.A333A|FASTKD2_ENST00000403094.3_Silent_p.A333A	NM_014929.3	NP_055744.2	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	333					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(2)	21				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		AGATGAAAGCCTTGAGGGAAT	0.323000													13	58					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566226	5566226	+	Silent	SNP	G	G	A	rs35658346		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5566226G>A	ENST00000322653.4	-	1	553	c.528C>T	c.(526-528)ttC>ttT	p.F176F	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGTCCTGCAGAAAGGCAGGC	0.493000													20	42					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124210210	124210210	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124210210C>T	ENST00000360013.3	+	31	4749	c.4622C>T	c.(4621-4623)cCc>cTc	p.P1541L	KALRN_ENST00000240874.3_Missense_Mutation_p.P1541L|KALRN_ENST00000460856.1_Missense_Mutation_p.P1532L	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1541	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GAGGGCGATCCCTGCAAATTC	0.562000													16	46					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70987031	70987031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70987031G>A	ENST00000354624.5	+	2	265	c.132G>A	c.(130-132)cgG>cgA	p.R44R	RP11-227H15.4_ENST00000450995.1_RNA|HKDC1_ENST00000395086.2_Silent_p.R44R	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	44					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						GGCGGTTCCGGGCTGAGATGG	0.597000													36	79					0	0	1	0	0
SMC5	23137	broad.mit.edu	37	9	72967122	72967122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72967122C>T	ENST00000361138.5	+	25	3239	c.3181C>T	c.(3181-3183)Cct>Tct	p.P1061S	SMC5_ENST00000471372.1_3'UTR	NM_015110.3	NP_055925.2	Q8IY18	SMC5_HUMAN	structural maintenance of chromosomes 5	1061					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(4)	35						GCAAAATCTTCCTTATTCTGA	0.378000													37	96					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13701487	13701487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13701487C>T	ENST00000265104.4	-	77	13501	c.13397G>A	c.(13396-13398)aGc>aAc	p.S4466N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4466					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGTAAACTGGCTGTTTCTTTC	0.393000									Kartagener syndrome				18	115					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36634028	36634028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:36634028G>A	ENST00000431169.1	-	12	1155	c.855C>T	c.(853-855)ttC>ttT	p.F285F	AOAH_ENST00000258749.5_Silent_p.F285F|AOAH_ENST00000535891.1_Silent_p.F253F|AOAH_ENST00000538464.1_Silent_p.F7F	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	285					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GTAGATTGATGAAAGAGTTCT	0.413000													25	42					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99441632	99441632	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:99441632C>T	ENST00000287042.4	+	2	1775	c.1425C>T	c.(1423-1425)tcC>tcT	p.S475S	KCNS2_ENST00000521839.1_Silent_p.S475S	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	475						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TAAATGATTCCCTACGTTAGC	0.493000													15	55					0	0	1	0	0
ARMC2	84071	broad.mit.edu	37	6	109190152	109190152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:109190152C>T	ENST00000392644.4	+	4	585	c.417C>T	c.(415-417)gcC>gcT	p.A139A	ARMC2_ENST00000368972.3_5'UTR	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	139							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		TCAGGGCTGCCTCCCAGCGGG	0.552000													21	34					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45537767	45537767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45537767C>T	ENST00000221452.8	+	11	1485	c.1335C>T	c.(1333-1335)ttC>ttT	p.F445F	RELB_ENST00000505236.1_Silent_p.F442F|RELB_ENST00000540120.1_Silent_p.F445F	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	445						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		TGGACCACTTCCTGCCCAACC	0.622000													5	11					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88027614	88027614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88027614C>T	ENST00000227266.5	-	7	1066	c.952G>A	c.(952-954)Gaa>Aaa	p.E318K		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	318					immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAAGCTTCTTCCACCAGCCCA	0.463000													16	77					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54416286	54416286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54416286C>T	ENST00000296733.1	-	10	1482	c.1308G>A	c.(1306-1308)ggG>ggA	p.G436G	CDC20B_ENST00000322374.6_Intron|CDC20B_ENST00000334206.5_3'UTR|CDC20B_ENST00000381375.2_Silent_p.G436G	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	436										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			GGATGCTCTTCCCAGCATTTA	0.453000													49	109					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77455135	77455135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77455135C>T	ENST00000451710.3	-	5	586	c.349G>A	c.(349-351)Gat>Aat	p.D117N	TRPM6_ENST00000376864.4_Missense_Mutation_p.D117N|TRPM6_ENST00000449912.2_Missense_Mutation_p.D112N|TRPM6_ENST00000359047.2_Missense_Mutation_p.D117N|TRPM6_ENST00000360774.1_Missense_Mutation_p.D117N|TRPM6_ENST00000376871.3_Missense_Mutation_p.D117N|TRPM6_ENST00000361255.3_Missense_Mutation_p.D112N|TRPM6_ENST00000376872.3_Missense_Mutation_p.D117N			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	117					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AGTTTTGTATCATAAGAAGTT	0.403000													15	26					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487829	248487829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248487829G>A	ENST00000317965.2	-	1	70	c.42C>T	c.(40-42)ctC>ctT	p.L14L		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGATTCCCAGGAGGAGGAAGT	0.453000													24	303					0	0	1	0	0
RNF20	56254	broad.mit.edu	37	9	104302572	104302572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104302572C>T	ENST00000389120.3	+	3	307	c.217C>T	c.(217-219)Cgt>Tgt	p.R73C		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	73					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		AGATGAACTTCGTGAGCACAT	0.453000													36	121					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44030298	44030298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44030298C>T	ENST00000269439.7	+	5	706	c.655C>T	c.(655-657)Cac>Tac	p.H219Y	RNF165_ENST00000543885.1_Missense_Mutation_p.H27Y	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	219							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		CCCTCAGCTTCACTTCCTTGC	0.522000													20	100					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890618	229890618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:229890618G>A	ENST00000392054.3	-	4	816	c.477C>T	c.(475-477)ttC>ttT	p.F159F	PID1_ENST00000354069.6_Silent_p.F161F|PID1_ENST00000392055.3_Silent_p.F128F|PID1_ENST00000409462.1_Silent_p.F79F|PID1_ENST00000482518.2_Intron	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	161	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GGGCCACCTGGAAGGTATCCA	0.572000													29	75					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171174688	171174688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171174688C>T	ENST00000441535.1	+	7	1215	c.1098C>T	c.(1096-1098)ctC>ctT	p.L366L	FMO2_ENST00000209929.7_Silent_p.L366L|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445290.1_RNA|RP1-127D3.4_ENST00000422841.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	366					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGTCAACCCTCGCGTGCATTG	0.448000													24	83					0	0	1	0	0
TPRG1	285386	broad.mit.edu	37	3	188956634	188956634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:188956634C>T	ENST00000345063.3	+	4	582	c.415C>T	c.(415-417)Cct>Tct	p.P139S	TPRG1_ENST00000433971.1_Missense_Mutation_p.P139S|TPRG1-AS2_ENST00000425454.1_RNA	NM_198485.3	NP_940887.1	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	139										endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|skin(2)|urinary_tract(1)	16	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		GCAGCGGATTCCTCTGAGCGC	0.478000													36	99					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469386	72469386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:72469386G>A	ENST00000296776.5	+	1	365	c.316G>A	c.(316-318)Gaa>Aaa	p.E106K	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	106						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		AGAAAGTGAGGAAAGGGTCCC	0.532000													29	84					0	0	1	0	0
IGLV3-1	28809	broad.mit.edu	37	22	23223458	23223458	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23223458C>T	ENST00000390319.2	+	0	280																											CCTCAGGGATCCCTGAGCGAT	0.547000													28	59					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25287187	25287187	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25287187C>T	ENST00000552781.1	+	0	328				SNORD109A_ENST00000459128.1_RNA																							ATCTGAGGTCCAGATGTGTGG	0.468000													6	22					0	0	1	0	0
CBR4	84869	broad.mit.edu	37	4	169923281	169923281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169923281G>A	ENST00000306193.3	-	4	644	c.476C>T	c.(475-477)tCa>tTa	p.S159L	CBR4_ENST00000509108.1_5'UTR|CBR4_ENST00000504480.1_Missense_Mutation_p.S159L	NM_032783.4	NP_116172.2	Q8N4T8	CBR4_HUMAN	carbonyl reductase 4	159					fatty acid biosynthetic process|protein homotetramerization	mitochondrial matrix	NADPH binding|NADPH dehydrogenase (quinone) activity|protein binding|quinone binding			kidney(1)|large_intestine(2)|lung(2)	5		Prostate(90;0.00263)|Renal(120;0.0183)|Melanoma(52;0.123)		GBM - Glioblastoma multiforme(119;0.0321)		AAGAGCACGTGAAAATCCAAC	0.343000													16	58					0	0	1	0	0
RHBDL3	162494	broad.mit.edu	37	17	30648242	30648242	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:30648242C>T	ENST00000269051.4	+	9	1223	c.1209C>T	c.(1207-1209)ccC>ccT	p.P403P	RHBDL3_ENST00000538145.1_Silent_p.P395P|RHBDL3_ENST00000536287.1_Silent_p.P305P	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	403					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				TGCCGCCTCCCCCCTGAGGGC	0.597000													20	19					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121414362	121414362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121414362C>T	ENST00000260197.7	+	13	1920	c.1791C>T	c.(1789-1791)ttC>ttT	p.F597F	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	597					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GCACTGTCTTCACCATCTTTG	0.512000													47	106					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72111608	72111608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:72111608G>A	ENST00000340726.3	-	18	2385	c.1746C>T	c.(1744-1746)gcC>gcT	p.A582A	RP11-326E22.1_ENST00000521685.1_RNA|EYA1_ENST00000303824.7_Silent_p.A576A|EYA1_ENST00000388742.4_Silent_p.A582A|EYA1_ENST00000388741.2_Silent_p.A548A|EYA1_ENST00000388743.2_Silent_p.A581A|EYA1_ENST00000388740.3_Silent_p.A549A|EYA1_ENST00000419131.1_Silent_p.A547A	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	582					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CATGGTGCAGGGCCATGAGGT	0.617000													7	20					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179597800	179597800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:179597800G>A	ENST00000467460.1	-	5	752	c.422C>T	c.(421-423)gCc>gTc	p.A141V	PEX5L_ENST00000485199.1_Missense_Mutation_p.A106V|PEX5L-AS1_ENST00000466064.1_RNA|PEX5L_ENST00000476138.1_Missense_Mutation_p.A98V|PEX5L_ENST00000465751.1_Missense_Mutation_p.A117V|PEX5L_ENST00000472994.1_Missense_Mutation_p.A82V|PEX5L_ENST00000468741.1_5'UTR|PEX5L_ENST00000467440.2_Intron|PEX5L_ENST00000464614.1_Intron|PEX5L_ENST00000392649.3_Intron|PEX5L_ENST00000263962.8_Missense_Mutation_p.A139V	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	141					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AGATCCATCGGCCTTTTTCTT	0.517000													20	74					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94353077	94353077	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94353077G>A	ENST00000515393.1	-	2	831	c.832C>T	c.(832-834)Cga>Tga	p.R278*	MCTP1_ENST00000312216.8_Nonsense_Mutation_p.R57*|MCTP1_ENST00000429576.2_Nonsense_Mutation_p.R57*|MCTP1_ENST00000505208.1_Nonsense_Mutation_p.R57*	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	278	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTACCTCCTCGATCTCGAGCA	0.413000													60	124					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12726000	12726000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12726000C>T	ENST00000376221.1	+	4	478	c.478C>T	c.(478-480)Cct>Tct	p.P160S		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	160						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		CCACCATTCCCCTGCCCTTTT	0.527000													10	103					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79313613	79313613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79313613C>T	ENST00000305089.3	-	4	281	c.201G>A	c.(199-201)atG>atA	p.M67I		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	67	C-type lectin.				cell proliferation	extracellular region	sugar binding	p.M67I(2)		central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						TGCCTGAATTCATGTTCTGGC	0.498000													31	104					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730381	140730381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140730381G>A	ENST00000523390.1	+	1	554	c.554G>A	c.(553-555)gGa>gAa	p.G185E	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCCTGATGGAAGTAAATAT	0.468000													42	207					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183694775	183694775	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183694775C>T	ENST00000511685.1	+	23	5166	c.5043C>T	c.(5041-5043)atC>atT	p.I1681I	RP11-18D7.2_ENST00000513255.1_RNA|TENM3_ENST00000406950.2_Silent_p.I1681I					teneurin transmembrane protein 3																		TGTCCTCGATCGATTCTTTCT	0.463000													19	148					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55280709	55280709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55280709C>T	ENST00000358193.3	+	8	1101	c.1047C>T	c.(1045-1047)agC>agT	p.S349S	C1orf177_ENST00000371273.3_Silent_p.S349S	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	349										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						TTATGGGAAGCTGGGTAAGTG	0.542000													42	105					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16877460	16877460	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:16877460G>A	ENST00000355661.3	-	5	317	c.305_splice	c.e5-1	p.P103_splice	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Splice_Site_p.P103_splice|PLEKHA7_ENST00000448080.2_Splice_Site_p.P103_splice			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	103					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TGTGGATTCGGCCTGTGAGGA	0.537000													54	159					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4855936	4855936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4855936G>A	ENST00000399583.3	-	8	2076	c.1889C>T	c.(1888-1890)cCc>cTc	p.P630L	RADIL_ENST00000538469.1_Missense_Mutation_p.P390L|RADIL_ENST00000536091.1_3'UTR	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	630	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGCCACCTCGGGGTGCACCTG	0.667000													7	14					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20129252	20129252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20129252C>T	ENST00000396085.1	+	37	7254	c.6893C>T	c.(6892-6894)tCg>tTg	p.S2298L	NAV2_ENST00000311043.8_Missense_Mutation_p.S1359L|NAV2_ENST00000349880.4_Missense_Mutation_p.S2295L|NAV2_ENST00000527559.2_Missense_Mutation_p.S2283L|NAV2_ENST00000540292.1_Missense_Mutation_p.S2285L|NAV2_ENST00000360655.4_Missense_Mutation_p.S2231L|NAV2_ENST00000533917.1_Missense_Mutation_p.S1359L|NAV2_ENST00000396087.3_Missense_Mutation_p.S2354L	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	2354						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GTGGACGGCTCGAGAGTGTGG	0.547000													134	318					0	0	1	0	0
AGBL2	79841	broad.mit.edu	37	11	47707561	47707561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47707561G>A	ENST00000525123.1	-	11	1957	c.1672C>T	c.(1672-1674)Cat>Tat	p.H558Y	AGBL2_ENST00000529712.1_5'UTR|AGBL2_ENST00000528244.1_Missense_Mutation_p.H520Y|AGBL2_ENST00000357610.3_Missense_Mutation_p.H558Y|AGBL2_ENST00000298861.4_Missense_Mutation_p.H558Y	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	558					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						CTGTGGCCATGGAAATCACAA	0.383000													41	68					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189910578	189910578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189910578C>T	ENST00000374866.3	-	46	3531	c.3257G>A	c.(3256-3258)gGa>gAa	p.G1086E		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1086					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent	p.G1086E(1)		NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCCAGGAGTTCCAGGGGCACC	0.498000													34	84					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129902393	129902393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129902393G>A	ENST00000368654.3	-	13	8086	c.7711C>T	c.(7711-7713)Cac>Tac	p.H2571Y	MKI67_ENST00000368653.3_Missense_Mutation_p.H2211Y	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2571	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCTTCAGTGTGACCTGGTGCT	0.483000													37	136					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170092404	170092404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170092404C>T	ENST00000263816.3	-	29	5151	c.4866G>A	c.(4864-4866)atG>atA	p.M1622I		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1622					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CACAAAAGTCCATGTAATCAA	0.443000													34	77					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232942	71232942	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:71232942C>T	ENST00000359042.2	+	3	1515	c.1321C>T	c.(1321-1323)Cag>Tag	p.Q441*	C17orf80_ENST00000268942.8_Nonsense_Mutation_p.Q441*|C17orf80_ENST00000535032.2_Nonsense_Mutation_p.Q441*|C17orf80_ENST00000577615.1_Nonsense_Mutation_p.Q441*|C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000426147.2_Nonsense_Mutation_p.Q441*|C17orf80_ENST00000255557.4_Nonsense_Mutation_p.Q441*	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	441						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			TCACACTCCTCAGAGCCCCTT	0.552000													31	67					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6730144	6730144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6730144C>T	ENST00000329858.4	-	2	1027	c.271G>A	c.(271-273)Gac>Aac	p.D91N	LPAR5_ENST00000431922.1_Missense_Mutation_p.D91N|LPAR5_ENST00000540335.1_5'UTR	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	91						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						CACAGGAGGTCGGGGAAGGGC	0.612000													5	18					0	0	1	0	0
ATG4B	23192	broad.mit.edu	37	2	242598552	242598552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242598552C>T	ENST00000405546.3	+	7	990	c.488C>T	c.(487-489)tCc>tTc	p.S163F	ATG4B_ENST00000474739.2_Missense_Mutation_p.S149F|ATG4B_ENST00000396411.3_Missense_Mutation_p.S89F|ATG4B_ENST00000402096.1_Missense_Mutation_p.S89F|ATG4B_ENST00000404914.3_Missense_Mutation_p.S163F			Q9Y4P1	ATG4B_HUMAN	autophagy related 4B, cysteine peptidase	163					autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		ACGTGGAGCTCCTTGGCGGTC	0.453000													12	24					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73678921	73678921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73678921C>T	ENST00000264448.6	+	8	5375	c.5264C>T	c.(5263-5265)tCc>tTc	p.S1755F	ALMS1_ENST00000409009.1_Missense_Mutation_p.S1713F|ALMS1_ENST00000377715.1_Missense_Mutation_p.S1755F	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1755	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ACTGTAACTTCCTCTTTCTAT	0.433000													14	138					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113241079	113241079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113241079G>A	ENST00000297405.5	-	70	11114	c.10870C>T	c.(10870-10872)Cat>Tat	p.H3624Y	CSMD3_ENST00000352409.3_Missense_Mutation_p.H3554Y|CSMD3_ENST00000343508.3_Missense_Mutation_p.H3584Y|CSMD3_ENST00000455883.2_Missense_Mutation_p.H3455Y	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3624						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTTGTACCATGAGGTTGATTT	0.279000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			29	60					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46998940	46998940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46998940C>T	ENST00000374314.4	+	1	1015	c.60C>T	c.(58-60)ccC>ccT	p.P20P	GPRIN2_ENST00000374317.1_Silent_p.P20P			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	20										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GCCTTCAGCCCCTGTCCCAGA	0.687000													9	134					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134670384	134670384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134670384C>T	ENST00000398015.3	+	3	665	c.295C>T	c.(295-297)Ctc>Ttc	p.L99F	EPHB1_ENST00000488154.1_3'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	99						integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CTGCAGCAGCCTCCCTAATGT	0.542000													19	37					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	144276933	144276933	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:144276933G>A	ENST00000295095.6	+	10	1092	c.925_splice	c.e10+1	p.G309_splice	RP11-570L15.2_ENST00000546678.1_RNA|RP11-570L15.1_ENST00000553076.1_RNA	NM_018460.3	NP_060930.3	Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	309	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		TGAGAAAAGAGGTGGGTGACT	0.453000													29	78					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22310278	22310278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22310278C>T	ENST00000337107.6	+	5	473	c.454C>T	c.(454-456)Ccc>Tcc	p.P152S		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	152	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						TGACATCCTTCCCAACGAGAC	0.622000													33	107					0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72423500	72423500	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72423500G>A	ENST00000359373.5	-	6	1712	c.861C>T	c.(859-861)gcC>gcT	p.A287A	ARAP1_ENST00000334211.8_Silent_p.A42A|ARAP1_ENST00000393609.3_Silent_p.A287A|ARAP1_ENST00000455638.2_Silent_p.A287A|ARAP1_ENST00000429686.1_Silent_p.A42A|ARAP1_ENST00000426523.1_Silent_p.A42A|ARAP1_ENST00000393605.3_Silent_p.A47A			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	287					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						CGCCCTCATAGGCGTGGTCAT	0.687000													58	86					0	0	1	0	0
LGI1	9211	broad.mit.edu	37	10	95552654	95552654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95552654G>A	ENST00000371418.4	+	6	918	c.658G>A	c.(658-660)Gat>Aat	p.D220N	LGI1_ENST00000371413.3_Missense_Mutation_p.D220N|LGI1_ENST00000542308.1_Missense_Mutation_p.D172N	NM_005097.2	NP_005088.1	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1	220	LRRCT.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(18)|ovary(2)|skin(1)	29		Colorectal(252;0.124)				GAAGGATTTTGATTGCATCAT	0.388000													42	99					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58980191	58980191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58980191C>T	ENST00000361050.3	-	1	233	c.148G>A	c.(148-150)Ggc>Agc	p.G50S		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	50	MACPF.					integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				TTGTCCCAGCCCCCTCCAGGT	0.493000													71	157					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940423	144940423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144940423C>T	ENST00000525985.1	-	2	7070	c.6999G>A	c.(6997-6999)gaG>gaA	p.E2333E				P58107	EPIPL_HUMAN	epiplakin 1	2333						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGATGCCGTGCTCCCGGACGA	0.711000													24	339					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38776440	38776440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:38776440C>T	ENST00000308973.4	-	4	1377	c.772G>A	c.(772-774)Gac>Aac	p.D258N	TLR10_ENST00000506111.1_Missense_Mutation_p.D258N|TLR10_ENST00000508334.1_Missense_Mutation_p.D258N|TLR10_ENST00000361424.2_Missense_Mutation_p.D258N	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	258					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						AGGAAAAGGTCGTCCCAGAGT	0.353000													11	40					0	0	1	0	0
CLIC5	53405	broad.mit.edu	37	6	45882124	45882124	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:45882124C>T	ENST00000185206.6	-	5	1058	c.906G>A	c.(904-906)aaG>aaA	p.K302K	CLIC5_ENST00000486570.1_5'UTR|CLIC5_ENST00000339561.6_Silent_p.K143K|CLIC5_ENST00000544153.1_Silent_p.K143K	NM_001114086.1	NP_001107558.1	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5	302	GST C-terminal.				female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	13						TCTTTAGAGCCTTGGTTAGGC	0.493000													12	108					0	0	1	0	0
ST3GAL1	6482	broad.mit.edu	37	8	134472027	134472027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134472027G>A	ENST00000319914.5	-	9	2030	c.1003C>T	c.(1003-1005)Cgg>Tgg	p.R335W	ST3GAL1_ENST00000399640.2_Missense_Mutation_p.R335W|ST3GAL1_ENST00000522652.1_Missense_Mutation_p.R335W|ST3GAL1_ENST00000521180.1_Missense_Mutation_p.R335W			Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	335					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(3)|large_intestine(2)|lung(11)|prostate(1)	17	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			TTGAAGATCCGGATTTTATTG	0.572000													8	113					0	0	1	0	0
SNRPN	6638	broad.mit.edu	37	15	25223432	25223432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25223432C>T	ENST00000444203.2	+	7	1703	c.664C>T	c.(664-666)Ccg>Tcg	p.P222S	SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000400098.1_Missense_Mutation_p.P218S|SNRPN_ENST00000346403.6_Missense_Mutation_p.P218S|SNRPN_ENST00000390687.4_Missense_Mutation_p.P218S|SNRPN_ENST00000554227.2_Missense_Mutation_p.P222S|SNRPN_ENST00000400100.1_Missense_Mutation_p.P218S|SNRPN_ENST00000577565.1_Missense_Mutation_p.P218S|SNRPN_ENST00000400097.1_Missense_Mutation_p.P218S			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	218	Repeat-rich region.				RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		CATGCCGCCTCCGGGAATGAG	0.572000									Prader-Willi syndrome				47	150					0	0	1	0	0
GPR25	2848	broad.mit.edu	37	1	200842325	200842325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200842325C>T	ENST00000304244.2	+	1	243	c.160C>T	c.(160-162)Ctg>Ttg	p.L54L		NM_005298.2	NP_005289.2	O00155	GPR25_HUMAN	G protein-coupled receptor 25	54						integral to plasma membrane				large_intestine(1)|lung(2)|ovary(1)|skin(1)	5						CGCCGTGGGCCTGCTGGGCAA	0.721000													4	19					0	0	1	0	0
CDC25C	995	broad.mit.edu	37	5	137627780	137627780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137627780G>A	ENST00000323760.6	-	8	919	c.641C>T	c.(640-642)tCc>tTc	p.S214F	CDC25C_ENST00000357274.3_Missense_Mutation_p.S171F|CDC25C_ENST00000513970.1_Missense_Mutation_p.S214F|CDC25C_ENST00000356505.3_Missense_Mutation_p.S184F|CDC25C_ENST00000514555.1_Missense_Mutation_p.S184F|CDC25C_ENST00000348983.3_Missense_Mutation_p.S141F|CDC25C_ENST00000415130.2_Missense_Mutation_p.S141F	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	214					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CATCGACGGGGAGCGATATAG	0.438000													59	133					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69752175	69752175	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69752175G>A	ENST00000409085.4	-	10	1421	c.1045C>T	c.(1045-1047)Cca>Tca	p.P349S	AAK1_ENST00000406297.3_Missense_Mutation_p.P349S|AAK1_ENST00000409068.1_Missense_Mutation_p.P349S	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	349						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						CTGGCCTTTGGCTGGGTCTTT	0.453000													18	82					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102825195	102825195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102825195C>T	ENST00000260302.3	-	3	531	c.503G>A	c.(502-504)gGa>gAa	p.G168E	MMP13_ENST00000340273.4_Missense_Mutation_p.G168E	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	168					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		ACCCTTAATTCCAAAAGAGAT	0.303000													12	36					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240497465	240497465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240497465G>A	ENST00000319653.9	+	13	4931	c.4701G>A	c.(4699-4701)caG>caA	p.Q1567Q	FMN2_ENST00000545751.1_Silent_p.Q163Q	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1567	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ACCTTTTTCAGGCCTCACAGA	0.363000													79	202					0	0	1	0	0
REG1A	5967	broad.mit.edu	37	2	79350286	79350286	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79350286G>A	ENST00000233735.1	+	6	549	c.446G>A	c.(445-447)tGg>tAg	p.W149*		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	149	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						TTCCAGAAATGGAAGGATGTG	0.418000													23	39					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34263239	34263239	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:34263239C>T	ENST00000262622.3	+	4	1304	c.546C>T	c.(544-546)tcC>tcT	p.S182S	CHST8_ENST00000434302.1_Silent_p.S182S|CHST8_ENST00000438847.2_Silent_p.S182S	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	182					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					GCCACGTGTCCCGTATCTTCG	0.706000													6	47					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105150462	105150462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105150462C>T	ENST00000428173.2	+	11	1204	c.901C>T	c.(901-903)Cgt>Tgt	p.R301C	NRK_ENST00000243300.9_Missense_Mutation_p.R301C			Q7Z2Y5	NRK_HUMAN	Nik related kinase	301	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						TTTCCTGTTTCGTCCTACTTC	0.363000										HNSCC(51;0.14)			7	7					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50090791	50090791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50090791C>T	ENST00000281631.5	+	12	1126	c.968C>T	c.(967-969)tCc>tTc	p.S323F	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505697.2_Missense_Mutation_p.S323F|PARP8_ENST00000503750.2_Missense_Mutation_p.S323F|PARP8_ENST00000505554.1_Missense_Mutation_p.S302F|PARP8_ENST00000514067.2_Missense_Mutation_p.S323F|PARP8_ENST00000514342.2_Missense_Mutation_p.S76F	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	323						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				AGGACTTGTTCCAGCACAGTC	0.527000													20	64					0	0	1	0	0
ZNF98	148198	broad.mit.edu	37	19	22574492	22574492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22574492C>T	ENST00000357774.5	-	4	1666	c.1545G>A	c.(1543-1545)gaG>gaA	p.E515E		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TGTAGGGTTTCTCTCCAGTAT	0.393000													23	77					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14801670	14801670	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14801670G>A	ENST00000380881.4	-	21	4492	c.3677C>T	c.(3676-3678)tCc>tTc	p.S1226F	FREM1_ENST00000422223.2_Missense_Mutation_p.S1225F|FREM1_ENST00000380880.3_Missense_Mutation_p.S1225F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1225					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GAGTTCCATGGAAAAGCTGTG	0.423000													11	25					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41758775	41758775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41758775G>A	ENST00000301178.4	+	16	2019	c.1829G>A	c.(1828-1830)cGa>cAa	p.R610Q	AXL_ENST00000593513.1_Missense_Mutation_p.R342Q|AXL_ENST00000359092.3_Missense_Mutation_p.R601Q	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	610	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GGTTCTGAACGAGAGAGCTTC	0.597000													21	92					0	0	1	0	0
DDR1	780	broad.mit.edu	37	6	30864450	30864450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30864450C>T	ENST00000324771.8	+	15	2225	c.1677C>T	c.(1675-1677)ccC>ccT	p.P559P	DDR1_ENST00000508312.1_Silent_p.P540P|DDR1_ENST00000452441.1_Silent_p.P559P|DDR1_ENST00000376575.3_Silent_p.P559P|DDR1_ENST00000361741.4_Intron|DDR1_ENST00000376569.3_Silent_p.P522P|DDR1_ENST00000418800.2_Silent_p.P522P|DDR1_ENST00000376570.4_Silent_p.P522P|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000376568.3_Silent_p.P559P|DDR1_ENST00000376567.2_Silent_p.P522P|DDR1_ENST00000513240.1_Silent_p.P559P|DDR1_ENST00000454612.2_Silent_p.P522P			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	559	Gly/Pro-rich.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CGCTTCTGCCCCCACCTCCCC	0.632000													34	68					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	108518107	108518107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:108518107C>T	ENST00000375915.2	-	1	976	c.838G>A	c.(838-840)Gaa>Aaa	p.E280K		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	280						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						TCAAACTCTTCGTATTTCTCC	0.527000													41	82					0	0	1	0	0
IGLV3-16	28799	broad.mit.edu	37	22	23090244	23090244	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23090244C>T	ENST00000390311.2	+	0	221																											CAGGCCAGTTCCCTGTGCTGG	0.522000													8	83					0	0	1	0	0
ZNF577	84765	broad.mit.edu	37	19	52376092	52376092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52376092G>A	ENST00000420592.1	-	6	2307	c.974C>T	c.(973-975)tCa>tTa	p.S325L	ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000485702.1_Intron|ZNF577_ENST00000451628.2_Missense_Mutation_p.S325L|ZNF577_ENST00000301399.5_Missense_Mutation_p.S384L			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CACCGTCAGTGAATTTATGGC	0.423000													39	133					0	0	1	0	0
OR52E8	390079	broad.mit.edu	37	11	5878886	5878886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5878886G>A	ENST00000537935.1	-	1	78	c.47C>T	c.(46-48)tCt>tTt	p.S16F	TRIM5_ENST00000380027.1_Intron	NM_001005168.1	NP_001005168.1	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E, member 8	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGGAATGAAGAAGGATGGAA	0.433000													57	159					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413483	124413483	+	Missense_Mutation	SNP	C	C	T	rs140680123		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124413483C>T	ENST00000306842.2	-	1	92	c.68G>A	c.(67-69)cGg>cAg	p.R23Q		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		GAGGGGGATCCGCAGTCCCGG	0.547000													12	135					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123540242	123540242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:123540242C>T	ENST00000422452.2	-	26	5143	c.5080G>A	c.(5080-5082)Gat>Aat	p.D1694N	TENM1_ENST00000371130.3_Missense_Mutation_p.D1687N|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1									p.D1689H(1)									TTGGAAGTATCTAGCTCCACT	0.458000													40	81					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154147141	154147141	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:154147141G>A	ENST00000389740.2	-	1	363	c.264C>T	c.(262-264)ttC>ttT	p.F88F		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	88						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCAAAAACATGAAGATGGTCA	0.483000													21	129					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69050671	69050671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:69050671G>A	ENST00000288368.4	+	33	4283	c.4006G>A	c.(4006-4008)Gaa>Aaa	p.E1336K		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1336					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AGCCATGTTAGAAGATACACT	0.303000													8	107					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142561068	142561068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142561068C>T	ENST00000392957.2	+	5	870	c.83C>T	c.(82-84)tCa>tTa	p.S28L	EPHB6_ENST00000442129.1_Missense_Mutation_p.S28L|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	28						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CTGGTGTCTTCAGTTCTGGCT	0.557000													14	38					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11905848	11905848	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11905848C>T	ENST00000256720.2	+	2	274	c.181C>T	c.(181-183)Cga>Tga	p.R61*	LPIN1_ENST00000449576.2_Nonsense_Mutation_p.R110*|LPIN1_ENST00000396098.1_Nonsense_Mutation_p.R67*|LPIN1_ENST00000425416.2_Nonsense_Mutation_p.R67*|LPIN1_ENST00000396099.1_Nonsense_Mutation_p.R67*	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	61	N-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity	p.R61R(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CCTGCGCTCCCGAGAGAAAGT	0.577000													27	55					0	0	1	0	0
PRAMEF22	653606	broad.mit.edu	37	1	13036637	13036637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:13036637C>T	ENST00000376187.1	+	2	709	c.709C>T	c.(709-711)Cgc>Tgc	p.R237C	PRAMEF6_ENST00000376192.5_Intron	NM_001100631.1	NP_001094101.1	A3QJZ6	PRA22_HUMAN	PRAME family member 22	237										kidney(1)|large_intestine(2)|lung(1)|skin(1)	5						GAGGAATCTTCGCAAACTCTT	0.473000													79	220					0	0	1	0	0
SLC1A2	6506	broad.mit.edu	37	11	35336622	35336622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:35336622C>T	ENST00000278379.3	-	3	540	c.258G>A	c.(256-258)atG>atA	p.M86I	SLC1A2_ENST00000395750.1_Missense_Mutation_p.M77I|SLC1A2_ENST00000395753.1_Missense_Mutation_p.M77I|SLC1A2_ENST00000606205.1_Missense_Mutation_p.M86I	NM_004171.3	NP_004162.2	P43004	EAA2_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 2	86					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|urinary_tract(1)	24	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	TTAGCATCCTCATGAGTATAT	0.493000													37	42					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120582833	120582833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120582833G>A	ENST00000300648.6	-	40	5061	c.5049C>T	c.(5047-5049)gcC>gcT	p.A1683A		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1683				A -> V (in Ref. 7; AAC51648).	regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTTCACCATGGCCCCAAGGG	0.577000													27	77					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31585462	31585462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31585462C>T	ENST00000356173.3	-	6	464	c.372G>A	c.(370-372)tcG>tcA	p.S124S	SUN5_ENST00000375523.3_Silent_p.S99S	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	124					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						CTTTCATTTTCGATGGTAAGT	0.473000													22	39					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782274	54782274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54782274G>A	ENST00000391748.1	-	7	1225	c.1098C>T	c.(1096-1098)ctC>ctT	p.L366L	LILRB2_ENST00000434421.1_Silent_p.L250L|LILRB2_ENST00000391746.1_Silent_p.L366L|LILRB2_ENST00000314446.5_Silent_p.L366L|LILRB2_ENST00000391749.4_Silent_p.L366L	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	366	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ATCTTAGACGGAGTGGGGCAT	0.572000													55	154					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40719516	40719516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40719516C>T	ENST00000253055.3	+	9	2218	c.1930C>T	c.(1930-1932)Ccc>Tcc	p.P644S		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	644					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GCCTGCCGAGCCCTccccggg	0.761000													6	26					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080427	152080427	+	Missense_Mutation	SNP	G	G	A	rs71585886		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152080427G>A	ENST00000368804.1	-	2	5265	c.5266C>T	c.(5266-5268)Cgt>Tgt	p.R1756C		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1756	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTTCCGGACGGAGCTGCTCT	0.592000													16	118					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75408264	75408264	+	Silent	SNP	C	C	T	rs71471632		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75408264C>T	ENST00000394810.2	-	4	1295	c.1146G>A	c.(1144-1146)gaG>gaA	p.E382E	SYNPO2L_ENST00000372873.4_Silent_p.E158E|SYNPO2L_ENST00000372872.4_Silent_p.E382E	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	382						cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					GCCCAGAGACCTCACTCAGCT	0.637000													26	74					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760539	54760539	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54760539C>T	ENST00000450632.1	-	3	245	c.168G>A	c.(166-168)gaG>gaA	p.E56E	LILRB5_ENST00000449561.2_Silent_p.E56E|LILRB5_ENST00000345866.6_Silent_p.E56E|LILRB5_ENST00000316219.5_Silent_p.E56E			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	56	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACGGTACTCCTCAGTCTCCA	0.627000													58	117					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98312041	98312041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98312041G>A	ENST00000264193.2	-	1	526	c.308C>T	c.(307-309)cCt>cTt	p.P103L		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	103						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CGAGGTCTTAGGCAACATCTC	0.741000													6	12					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149512446	149512446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149512446G>A	ENST00000261799.4	-	7	1463	c.994C>T	c.(994-996)Cgg>Tgg	p.R332W		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	332	Ig-like C2-type 4.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTCCGGCTCCGATGCAGCTCA	0.652000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								4	5					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913368	6913368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6913368G>A	ENST00000299459.2	-	1	462	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCAACATAGCGATCATAGGAC	0.483000													51	32					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103137058	103137058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103137058C>T	ENST00000428762.1	-	56	9267	c.9108G>A	c.(9106-9108)gtG>gtA	p.V3036V	CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000343529.5_Silent_p.V3036V|RELN_ENST00000424685.2_Silent_p.V3036V	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3036					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAGCACGCTCCACCCCAGAGA	0.483000													20	72					0	0	1	0	0
USP30	84749	broad.mit.edu	37	12	109511303	109511303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109511303C>T	ENST00000257548.5	+	7	779	c.686C>T	c.(685-687)aCt>aTt	p.T229I	USP30_ENST00000392784.2_Missense_Mutation_p.T198I	NM_032663.3	NP_116052.2	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	229					ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(7)|kidney(1)|large_intestine(1)|liver(2)|lung(11)|prostate(1)|skin(3)|stomach(2)	28						GGAAGACTCACTAGTAATATG	0.403000													13	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9002672	9002672	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9002672G>A	ENST00000397910.4	-	51	40347	c.40142_splice	c.e51-1	p.P13382_splice	MUC16_ENST00000380951.5_Splice_Site_p.P23_splice	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13384	SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCTTCTCAGGCCTAGGGAGG	0.547000													18	60					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46501502	46501502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46501502C>T	ENST00000361297.2	+	29	5444	c.5161C>T	c.(5161-5163)Ccc>Tcc	p.P1721S	MAST2_ENST00000372008.1_Intron|MAST2_ENST00000372009.2_Missense_Mutation_p.P1531S	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1721					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					TTATGAGGATCCCAGCCAGGG	0.577000													5	68					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237538048	237538048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237538048C>T	ENST00000366574.2	+	7	733	c.416C>T	c.(415-417)tCa>tTa	p.S139L	RYR2_ENST00000360064.6_Missense_Mutation_p.S137L|RYR2_ENST00000542537.1_Missense_Mutation_p.S123L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	139	MIR 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCCCGGTCTTCAACTGATAAG	0.478000													6	10					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152557374	152557374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152557374C>T	ENST00000367255.5	-	110	20865	c.20264G>A	c.(20263-20265)cGa>cAa	p.R6755Q	SYNE1_ENST00000341594.5_Missense_Mutation_p.R6367Q|SYNE1_ENST00000423061.1_Missense_Mutation_p.R6684Q|SYNE1_ENST00000356820.4_Missense_Mutation_p.R1279Q|SYNE1_ENST00000448038.1_Missense_Mutation_p.R6684Q|SYNE1_ENST00000265368.4_Missense_Mutation_p.R6755Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6755					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TATCAGAAGTCGTTTCCCATC	0.338000										HNSCC(10;0.0054)			30	32					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935936	30935936	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30935936G>A	ENST00000355537.3	+	2	1614	c.1467G>A	c.(1465-1467)ctG>ctA	p.L489L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.L489L(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ACTCCCTCCTGGGATGCCTCA	0.657000													26	54					0	0	1	0	0
PDHA2	5161	broad.mit.edu	37	4	96761857	96761857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:96761857G>A	ENST00000295266.4	+	1	619	c.556G>A	c.(556-558)Gag>Aag	p.E186K		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	186					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	AGGAAACGATGAGATCTGTTT	0.478000													33	82					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8486138	8486138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8486138G>A	ENST00000381196.4	-	25	3222	c.2679C>T	c.(2677-2679)ttC>ttT	p.F893F	PTPRD_ENST00000358503.5_Silent_p.F871F|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000356435.5_Silent_p.F893F|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000540109.1_Silent_p.F893F|PTPRD_ENST00000360074.4_Silent_p.F880F|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000355233.5_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	893	Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTGAGAGCCTGAAGACGTATG	0.463000										TSP Lung(15;0.13)			27	34					0	0	1	0	0
MAML1	9794	broad.mit.edu	37	5	179193008	179193008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179193008C>T	ENST00000292599.3	+	2	1260	c.997C>T	c.(997-999)Cct>Tct	p.P333S	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	333					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCTCTGCCCCTGTGAGTAC	0.602000													20	41					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15770051	15770051	+	Silent	SNP	C	C	T	rs140820169	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15770051C>T	ENST00000221307.7	+	13	1467	c.1419C>T	c.(1417-1419)ttC>ttT	p.F473F	CYP4F3_ENST00000591058.1_Silent_p.F473F|CYP4F3_ENST00000585846.1_Silent_p.F473F|CYP4F3_ENST00000586182.1_Silent_p.F473F	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	473					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GGCAGGCGTTCGCGATGGCGG	0.672000													19	25					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196913028	196913028	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196913028T>C	ENST00000312428.6	-	4	342	c.242A>G	c.(241-243)cAg>cGg	p.Q81R	DNAH7_ENST00000410072.1_Missense_Mutation_p.Q81R	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	81	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACCATGGGACTGTTCATTTTT	0.363000													24	75					0	0	1	0	0
SLC2A1	6513	broad.mit.edu	37	1	43394917	43394917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43394917G>A	ENST00000426263.3	-	7	1114	c.936C>T	c.(934-936)ggC>ggT	p.G312G	SLC2A1_ENST00000475162.1_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1	312					carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CGATACCGGAGCCAATGGTGG	0.587000													7	29					0	0	1	0	0
TFE3	7030	broad.mit.edu	37	X	48896732	48896732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48896732G>A	ENST00000315869.7	-	3	693	c.434C>T	c.(433-435)cCt>cTt	p.P145L	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	145					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						GGCAGGTGCAGGACTGGGGAA	0.682000			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								13	14					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153913883	153913883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153913883G>A	ENST00000361217.4	-	7	1507	c.1089C>T	c.(1087-1089)ttC>ttT	p.F363F		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	363	DENN.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTGGGGAAGGGAAGGGAACGT	0.592000													10	29					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117665424	117665424	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117665424C>T	ENST00000317775.6	-	23	4113	c.3428G>A	c.(3427-3429)tGg>tAg	p.W1143*	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Nonsense_Mutation_p.W1177*	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1143	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GCCCCATTTCCATTCCTCGTA	0.592000													17	58					0	0	1	0	0
TSPY1	7258	broad.mit.edu	37	Y	9305956	9305956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:9305956C>T	ENST00000451548.1	+	3	658	c.612C>T	c.(610-612)ttC>ttT	p.F204F	AC006156.1_ENST00000423213.1_Intron|AC006156.1_ENST00000450145.1_Intron|TSPY3_ENST00000440483.1_Intron|TSPY1_ENST00000423647.2_Silent_p.F210F	NM_001197242.1|NM_003308.3	NP_001184171.1|NP_003299.2	Q01534	TSPY1_HUMAN	testis specific protein, Y-linked 1	204					cell differentiation|cell proliferation|gonadal mesoderm development|nucleosome assembly|spermatogenesis	cytoplasm|nucleus	identical protein binding			lung(4)	4						TCATGTTGTTCTTTCGGAGTA	0.478000													47	272					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188492	57188492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57188492C>T	ENST00000331162.4	-	5	900	c.630G>A	c.(628-630)gaG>gaA	p.E210E		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TGTAGGACTTCTCCCTAGTAT	0.333000													10	32					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165946689	165946689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165946689C>T	ENST00000360093.3	-	28	6465	c.5974G>A	c.(5974-5976)Gga>Aga	p.G1992R	SCN3A_ENST00000409101.3_Missense_Mutation_p.G1943R|AC013463.2_ENST00000431341.1_RNA|SCN3A_ENST00000283254.7_Missense_Mutation_p.G1992R|SCN3A_ENST00000540861.1_Missense_Mutation_p.G475R	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1992						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ACCTCTTTTCCTTTGCTTTCT	0.358000													6	15					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610225	47610225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47610225G>A	ENST00000371891.3	+	8	932	c.901G>A	c.(901-903)Gag>Aag	p.E301K	CYP4A22_ENST00000485117.1_Intron|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000371890.3_Intron|CYP4A22_ENST00000294337.3_Missense_Mutation_p.E301K	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	301						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTCCCAGATGGAGAATGGGAG	0.537000													31	154					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597494	136597494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136597494C>T	ENST00000531224.1	-	5	1421	c.1169G>A	c.(1168-1170)gGa>gAa	p.G390E	BCLAF1_ENST00000392348.2_Missense_Mutation_p.G388E|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000527759.1_Missense_Mutation_p.G388E|BCLAF1_ENST00000527536.1_Missense_Mutation_p.G390E|BCLAF1_ENST00000353331.4_Missense_Mutation_p.G388E	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	390					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTTTTGTTTTCCAGACTCTTT	0.423000													56	560					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640205	34640205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34640205C>T	ENST00000537011.1	+	3	518	c.136C>T	c.(136-138)Cct>Tct	p.P46S	NUTM1_ENST00000438749.3_Missense_Mutation_p.P36S|NUTM1_ENST00000333756.4_Missense_Mutation_p.P18S					NUT midline carcinoma, family member 1																		GAGCATGAAACCTAGTGCCGC	0.532000													13	69					0	0	1	0	0
SCRN1	9805	broad.mit.edu	37	7	29976195	29976195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:29976195G>A	ENST00000426154.1	-	6	1058	c.882C>T	c.(880-882)ttC>ttT	p.F294F	SCRN1_ENST00000416113.2_Silent_p.F120F|SCRN1_ENST00000242059.5_Silent_p.F294F|SCRN1_ENST00000409497.1_Silent_p.F294F	NM_001145513.1	NP_001138985.1	Q12765	SCRN1_HUMAN	secernin 1	294					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(2)|prostate(2)|skin(2)	25						GGGTTCCAGTGAAGTAGTGAA	0.522000													37	149					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57597283	57597283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57597283G>A	ENST00000243077.3	+	70	11396	c.10930G>A	c.(10930-10932)Gag>Aag	p.E3644K		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3644	LDL-receptor class A 28.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CGGCAGCGACGAGGAGGCCTG	0.677000													4	7					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046936	42046936	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42046936A>T	ENST00000372584.1	-	3	4547	c.3533T>A	c.(3532-3534)aTg>aAg	p.M1178K	HIVEP3_ENST00000247584.5_Missense_Mutation_p.M1178K|HIVEP3_ENST00000372583.1_Missense_Mutation_p.M1178K|HIVEP3_ENST00000429157.2_Missense_Mutation_p.M1178K	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1178					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AAGTGGGGGCATGGAGTATGG	0.577000													38	127					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991276	70991276	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70991276A>G	ENST00000256389.3	-	2	593	c.349T>C	c.(349-351)Ttt>Ctt	p.F117L	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	67					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TGTCCCCCAAACCGCAGGCTA	0.522000													29	77					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189923576	189923576	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189923576C>T	ENST00000374866.3	-	32	2403	c.2130_splice	c.e32+1	p.R710_splice		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	710					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent	p.R710I(1)		NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AATACTTACTCTAGGTCCTAA	0.343000													10	35					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45410157	45410157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45410157G>A	ENST00000332700.6	-	4	1103	c.932C>T	c.(931-933)cCc>cTc	p.P311L		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	311						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		TGCTTCTGGGGGTGGTGCCCC	0.483000													27	57					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995378	140995378	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140995378C>T	ENST00000285879.4	+	4	2474	c.2188C>T	c.(2188-2190)Cct>Tct	p.P730S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	730							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGTTTCCTCCTCAGGG	0.547000										HNSCC(15;0.026)			65	71					0	0	1	0	0
PSAT1	29968	broad.mit.edu	37	9	80943007	80943007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:80943007C>T	ENST00000376588.3	+	8	978	c.910C>T	c.(910-912)Cca>Tca	p.P304S	PSAT1_ENST00000347159.2_Intron	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	304					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	GATGAATATTCCATTCCGCAT	0.368000													12	39					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230326	140230326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140230326C>T	ENST00000378122.3	+	1	2970	c.2246C>T	c.(2245-2247)tCg>tTg	p.S749L	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.S749L|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAGTTGGTCGTACTCGCAG	0.647000													43	36					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30749771	30749771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30749771C>T	ENST00000262518.4	+	34	8795	c.8410C>T	c.(8410-8412)Ccc>Tcc	p.P2804S	SRCAP_ENST00000395059.2_Missense_Mutation_p.P2742S|SRCAP_ENST00000344771.4_Missense_Mutation_p.P2646S	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2804	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			ATCCTCCCCTCCCATTGGTGG	0.647000													7	102					0	0	1	0	0
CLASRP	11129	broad.mit.edu	37	19	45563679	45563679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45563679C>T	ENST00000544944.2	+	8	1435	c.743C>T	c.(742-744)gCc>gTc	p.A248V	CLASRP_ENST00000391953.4_Missense_Mutation_p.A186V|CLASRP_ENST00000221455.3_Missense_Mutation_p.A248V			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	248					mRNA processing|RNA splicing	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						GAGGCAGAGGCCATCAAGCAT	0.592000													22	65					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16504332	16504332	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:16504332C>T	ENST00000304523.5	-	8	1379	c.1056G>A	c.(1054-1056)tgG>tgA	p.W352*	LDB2_ENST00000502640.1_3'UTR|RP11-446J8.1_ENST00000512370.1_RNA|LDB2_ENST00000441778.2_3'UTR|LDB2_ENST00000515064.1_Nonsense_Mutation_p.W350*	NM_001290.3	NP_001281.1	O43679	LDB2_HUMAN	LIM domain binding 2	352							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						GTTTACTGTTCCACGGGCTGT	0.522000													56	160					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37709508	37709508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37709508G>A	ENST00000248901.6	+	13	1328	c.1141G>A	c.(1141-1143)Gac>Aac	p.D381N		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	381					regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CCCCTTCTACGACCTGGTCTC	0.587000													13	91					0	0	1	0	0
APOBEC2	10930	broad.mit.edu	37	6	41029269	41029269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41029269G>A	ENST00000244669.2	+	2	378	c.334G>A	c.(334-336)Gac>Aac	p.D112N		NM_006789.3	NP_006780.1	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	112					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding	p.D112N(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)	10	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCCAGCCTTCGACCCAGCCCT	0.572000													60	166					0	0	1	0	0
DKK4	27121	broad.mit.edu	37	8	42233236	42233236	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42233236C>T	ENST00000220812.2	-	2	410	c.224G>A	c.(223-225)cGa>cAa	p.R75Q		NM_014420.2	NP_055235.1	Q9UBT3	DKK4_HUMAN	dickkopf WNT signaling pathway inhibitor 4	75	DKK-type Cys-1.				multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region		p.R75Q(1)		NS(1)|endometrium(1)|large_intestine(7)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			CATGGCATCTCGCTGGCACCT	0.552000													11	62					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89391132	89391132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:89391132C>T	ENST00000336596.2	+	5	1423	c.1198C>T	c.(1198-1200)Ctg>Ttg	p.L400L	EPHA3_ENST00000452448.2_Silent_p.L400L|EPHA3_ENST00000494014.1_Silent_p.L400L	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	400	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GACAGACCTTCTGGCACATAC	0.507000										TSP Lung(6;0.00050)			26	54					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175764149	175764149	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:175764149G>A	ENST00000443967.1	+	11	2763	c.2356_splice	c.e11+1	p.E786_splice	SIMC1_ENST00000341199.6_Splice_Site_p.E371_splice|SIMC1_ENST00000430704.2_Splice_Site_p.E371_splice|SIMC1_ENST00000332772.4_Splice_Site_p.E247_splice					SUMO-interacting motifs containing 1																		TGTTTTAAGAGGTAAGGAGCA	0.403000													24	112					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165791	172165791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172165791C>T	ENST00000241256.2	-	1	455	c.413G>A	c.(412-414)aGc>aAc	p.S138N	GHSR_ENST00000427970.1_Missense_Mutation_p.S138N	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	138					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GCGCTCGACGCTCAGCGCTGT	0.622000													8	28					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628883	3628883	+	Missense_Mutation	SNP	C	C	T	rs150287837		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3628883C>T	ENST00000325418.4	+	1	1673	c.1654C>T	c.(1654-1656)Cgc>Tgc	p.R552C	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	552	Protein kinase.				cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										AGTGTGCAACCGCACAGAAGG	0.478000													33	34					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327285	52327285	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52327285C>T	ENST00000339223.4	+	2	463	c.284C>T	c.(283-285)tCa>tTa	p.S95L	FPR3_ENST00000595991.1_Missense_Mutation_p.S95L	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	95					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						CCTTTTGGCTCATTCCTATGT	0.453000													38	93					0	0	1	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117774392	117774392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117774392G>A	ENST00000528626.1	-	11	1623	c.1550C>T	c.(1549-1551)cCc>cTc	p.P517L	TMPRSS13_ENST00000524993.1_Missense_Mutation_p.P552L|TMPRSS13_ENST00000445164.2_Missense_Mutation_p.P552L|TMPRSS13_ENST00000430170.2_Missense_Mutation_p.P552L	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	547	Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GTAAATCCAGGGAAGAACTTC	0.577000													14	28					0	0	1	0	0
CES3	23491	broad.mit.edu	37	16	66998585	66998585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66998585C>T	ENST00000303334.4	+	6	845	c.774C>T	c.(772-774)atC>atT	p.I258I	CES3_ENST00000394037.1_Silent_p.I258I	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	258						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GTGGGGTCATCACCACCCCAG	0.587000													28	96					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436697	248436697	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248436697C>T	ENST00000318021.2	-	1	441	c.420G>A	c.(418-420)ctG>ctA	p.L140L		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGTCATCCTCAGGCACAGCT	0.582000													32	167					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227907816	227907816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227907816G>A	ENST00000396625.3	-	36	3581	c.3374C>T	c.(3373-3375)tCc>tTc	p.S1125F	COL4A4_ENST00000329662.7_Missense_Mutation_p.S1125F	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1125	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGGTCCAGAGGAGCCAGGTGG	0.532000													22	44					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105353296	105353296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105353296C>T	ENST00000453495.1	+	12	2951	c.2723C>T	c.(2722-2724)tCc>tTc	p.S908F	CEP170B_ENST00000556508.1_Missense_Mutation_p.S837F|CEP170B_ENST00000418279.1_Missense_Mutation_p.S837F|CEP170B_ENST00000414716.3_Missense_Mutation_p.S907F					centrosomal protein 170B																		GACTTCCACTCCCAGGACACC	0.682000													20	58					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6083359	6083359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6083359G>A	ENST00000409021.3	-	6	1527	c.1078C>T	c.(1078-1080)Ctc>Ttc	p.L360F	JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000410077.2_Missense_Mutation_p.L195F|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.L360F|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.L360F|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.L195F	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	360	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding	p.L360I(2)		NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCCCGCGTGAGGTTCTTGATT	0.532000													26	80					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435835	158435835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158435835C>T	ENST00000289451.2	+	1	564	c.484C>T	c.(484-486)Cta>Tta	p.L162L		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					CACCACCTCCCTAGTATTTCA	0.557000													75	199					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76980019	76980019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76980019C>T	ENST00000315938.4	-	8	824	c.574G>A	c.(574-576)Gag>Aag	p.E192K	GDPD4_ENST00000376217.2_Missense_Mutation_p.E192K	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	192					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						CCCAAATTCTCCTTCTCCTGA	0.453000													42	126					0	0	1	0	0
ABCA11P	79963	broad.mit.edu	37	4	419584	419584	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:419584G>A	ENST00000451020.2	-	0	1454					NR_002451.2																						AGTTTCCATCGAACTGTTATA	0.393000													8	31					0	0	1	0	0
U2SURP	23350	broad.mit.edu	37	3	142741799	142741799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142741799C>T	ENST00000473835.2	+	12	1213	c.1123C>T	c.(1123-1125)Ccc>Tcc	p.P375S	U2SURP_ENST00000493598.2_Missense_Mutation_p.P374S|U2SURP_ENST00000397933.2_5'UTR	NM_001080415.1	NP_001073884.1	O15042	SR140_HUMAN	U2 snRNP-associated SURP domain containing	375	Pro-rich.				RNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	31						ACATACGCTTCCCCCACCTCC	0.433000													4	24					0	0	1	0	0
DPYSL3	1809	broad.mit.edu	37	5	146777300	146777300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:146777300C>T	ENST00000343218.5	-	12	1929	c.1732G>A	c.(1732-1734)Ggg>Agg	p.G578R	DPYSL3_ENST00000398514.3_Missense_Mutation_p.G464R|DPYSL3_ENST00000534907.1_Missense_Mutation_p.G90R	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	464					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCCAGCCCCCTGGGTCACG	0.562000													31	94					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49137072	49137072	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49137072G>A	ENST00000306125.6	-	16	1734	c.1397C>T	c.(1396-1398)tCc>tTc	p.S466F	QARS_ENST00000414533.1_Missense_Mutation_p.S455F			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	466					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	CCAGAAGTAGGAAGAGCGTCT	0.567000													5	56					0	0	1	0	0
OR4C11	219429	broad.mit.edu	37	11	55371562	55371562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55371562C>T	ENST00000302231.4	-	1	312	c.288G>A	c.(286-288)atG>atA	p.M96I		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						AGACTTGTGTCATGCACTCAT	0.413000													53	101					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585343	7585343	+	Silent	SNP	G	G	A	rs148798300		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7585343G>A	ENST00000379802.3	+	24	8189	c.7848G>A	c.(7846-7848)tcG>tcA	p.S2616S	DSP_ENST00000418664.2_Silent_p.S2017S	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2616	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGGAAGAATCGAGCCCCATTG	0.483000													46	94					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194117701	194117701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:194117701C>T	ENST00000401815.1	-	1	1382	c.1311G>A	c.(1309-1311)cgG>cgA	p.R437R	GP5_ENST00000323007.3_Silent_p.R437R			P40197	GPV_HUMAN	glycoprotein V (platelet)	437	LRRCT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		CTAGGTGCTGCCGCAGCCACC	0.756000													7	1					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170222320	170222320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:170222320G>A	ENST00000518525.1	+	6	813	c.349G>A	c.(349-351)Gtg>Atg	p.V117M	GABRP_ENST00000519385.1_Missense_Mutation_p.V117M|GABRP_ENST00000519598.1_Missense_Mutation_p.V117M|GABRP_ENST00000265294.4_Missense_Mutation_p.V117M			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	117						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GTTCCTCTGGGTGCCAGATAC	0.552000													55	130					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510452	56510452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56510452G>A	ENST00000302957.3	-	1	835	c.836C>T	c.(835-837)tCc>tTc	p.S279F		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGAGTAGGTGGAACTAGGCCT	0.468000													36	85					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813752	123813752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123813752G>A	ENST00000321252.2	-	1	828	c.794C>T	c.(793-795)gCt>gTt	p.A265V		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TTTGGACTGAGCCTCTGACAT	0.507000													43	139					0	0	1	0	0
LHX6	26468	broad.mit.edu	37	9	124979518	124979518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:124979518C>T	ENST00000394319.4	-	5	615	c.511G>A	c.(511-513)Gac>Aac	p.D171N	LHX6_ENST00000340587.3_Missense_Mutation_p.D171N|LHX6_ENST00000373754.2_Missense_Mutation_p.D142N|LHX6_ENST00000541397.2_Missense_Mutation_p.D160N|LHX6_ENST00000373755.2_Missense_Mutation_p.D142N|LHX6_ENST00000559895.1_5'UTR	NM_014368.4	NP_055183.2	Q9UPM6	LHX6_HUMAN	LIM homeobox 6	142	LIM zinc-binding 2.|Required for interaction with LBD1 (By similarity).				cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)	8						CGCACCCAGTCGCTGGCGTAG	0.662000													19	24					0	0	1	0	0
GBE1	2632	broad.mit.edu	37	3	81698074	81698074	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:81698074G>A	ENST00000429644.2	-	5	1267	c.624C>T	c.(622-624)tcC>tcT	p.S208S	GBE1_ENST00000489715.1_Silent_p.S167S	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	208					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TTCCTTCATGGGAAGAAATTC	0.318000									Glycogen Storage Disease, type IV				9	18					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052304	15052304	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15052304G>A	ENST00000248072.3	+	1	4	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					CGGCCCCATGGAAAGAGGAAA	0.468000													51	146					0	0	1	0	0
ISX	91464	broad.mit.edu	37	22	35478634	35478634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:35478634G>A	ENST00000308700.6	+	2	1305	c.353G>A	c.(352-354)aGg>aAg	p.R118K	ISX_ENST00000404699.2_Missense_Mutation_p.R118K	NM_001008494.1	NP_001008494.1	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	118						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(12)|ovary(3)|prostate(1)|skin(4)	26						CTGGCAGCCAGGATCAACCTC	0.572000													17	59					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53766094	53766094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53766094C>T	ENST00000288139.3	+	19	2636	c.2518C>T	c.(2518-2520)Cct>Tct	p.P840S	CACNA1D_ENST00000422281.2_Missense_Mutation_p.P820S|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P820S	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	820					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CCCCTATCCGCCTTGCGATGT	0.537000													7	68					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52603784	52603784	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52603784G>A	ENST00000395489.2	-	6	573	c.177C>T	c.(175-177)gaC>gaT	p.D59D	A1CF_ENST00000373993.1_Silent_p.D66D|A1CF_ENST00000282641.2_Silent_p.D66D|A1CF_ENST00000373997.3_Silent_p.D66D|A1CF_ENST00000374001.1_Silent_p.D66D|A1CF_ENST00000395495.1_Silent_p.D66D|A1CF_ENST00000373995.3_Silent_p.D74D	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	66	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CCTCAAAAAGGTCTCGGGGAA	0.393000													46	155					0	0	1	0	0
SH3RF1	57630	broad.mit.edu	37	4	170028273	170028273	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:170028273G>A	ENST00000284637.9	-	11	2564	c.2223C>T	c.(2221-2223)acC>acT	p.T741T		NM_020870.3	NP_065921.2	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	741						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CCACTTCTAGGGTGGGCGATG	0.577000													15	45					0	0	1	0	0
INO80C	125476	broad.mit.edu	37	18	33060487	33060487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:33060487G>A	ENST00000592173.1	-	2	255	c.197C>T	c.(196-198)cCc>cTc	p.P66L	INO80C_ENST00000441607.2_Missense_Mutation_p.P102L|INO80C_ENST00000334598.7_Missense_Mutation_p.P66L|RP11-322E11.6_ENST00000589258.1_Intron|INO80C_ENST00000586489.1_Missense_Mutation_p.P11L|INO80C_ENST00000590757.1_Intron			Q6PI98	IN80C_HUMAN	INO80 complex subunit C	66					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|MLL1 complex				central_nervous_system(1)|endometrium(1)|lung(3)|prostate(2)|skin(1)	8						AAACTCAGAGGGCACCATTTT	0.408000													17	152					0	0	1	0	0
CHST12	55501	broad.mit.edu	37	7	2472296	2472296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2472296C>T	ENST00000258711.6	+	2	157	c.22C>T	c.(22-24)Cgg>Tgg	p.R8W		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	8					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CCGGCTGTTCCGGCTGTGGCT	0.657000													17	35					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18776967	18776967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18776967G>A	ENST00000380548.4	+	19	3079	c.2740G>A	c.(2740-2742)Gac>Aac	p.D914N		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	914	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CTGGGAGAAGGACGGCCAGCA	0.677000													6	47					0	0	1	0	0
RFX5	5993	broad.mit.edu	37	1	151315436	151315436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151315436G>A	ENST00000290524.4	-	11	1255	c.1077C>T	c.(1075-1077)gcC>gcT	p.A359A	RFX5_ENST00000452671.2_Silent_p.A359A|RFX5_ENST00000452513.2_Silent_p.A319A|RFX5_ENST00000368870.2_Silent_p.A359A	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	359						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCACTTTCAGGGCACCTGAAG	0.592000													37	73					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101198189	101198189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:101198189G>A	ENST00000294728.2	+	7	1842	c.1741G>A	c.(1741-1743)Gga>Aga	p.G581R	VCAM1_ENST00000370119.4_Missense_Mutation_p.G519R|VCAM1_ENST00000370115.1_Missense_Mutation_p.G382R|VCAM1_ENST00000347652.2_Missense_Mutation_p.G489R	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	581	Ig-like C2-type 6.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	TTTATGTGAAGGAATTAACCA	0.413000													55	137					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455470	84455470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:84455470G>A	ENST00000377084.2	-	1	1058	c.173C>T	c.(172-174)tCc>tTc	p.S58F		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	58						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GTAAAACTGGGAAGTCGGGGC	0.433000													17	78					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34241243	34241243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34241243G>A	ENST00000374114.3	-	3	2265	c.2002C>T	c.(2002-2004)Ccc>Tcc	p.P668S	CPNE1_ENST00000397445.1_Intron|RBM12_ENST00000359646.1_Missense_Mutation_p.P668S|CPNE1_ENST00000317677.5_Intron|CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000397446.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.P668S|CPNE1_ENST00000352393.4_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	668	Gly-rich.|Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CCTGCACCGGGAAGTCCTGCA	0.587000													21	39					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724971	49724971	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49724971C>A	ENST00000551245.1	+	13	2454	c.2343C>A	c.(2341-2343)ctC>ctA	p.L781L	TROAP_ENST00000257909.3_Intron|TROAP_ENST00000547923.1_Intron			Q12815	TROAP_HUMAN	trophinin associated protein	0					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						CCCCAGACCTCCCTCTAAATT	0.587000													11	27					4.68919e-08	4.7042e-08	1	1	0
NOXRED1	122945	broad.mit.edu	37	14	77861022	77861022	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77861022G>A	ENST00000380835.2	-	6	1198	c.1032C>T	c.(1030-1032)tcC>tcT	p.S344S		NM_001113475.2	NP_001106946.1	Q6NXP6	CN148_HUMAN	NADP-dependent oxidoreductase domain containing 1	344					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9						CTTTGGTTAGGGAGATGCCAA	0.443000													30	58					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22941645	22941645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22941645G>A	ENST00000397104.3	-	5	792	c.793C>T	c.(793-795)Ctt>Ttt	p.L265F	ZNF99_ENST00000596209.1_Missense_Mutation_p.L356F					zinc finger protein 99									p.L265I(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGTTTTCTAAGGGTTGAGGAC	0.368000													37	95					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900098	151900098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151900098C>T	ENST00000393900.3	-	3	1056	c.703G>A	c.(703-705)Gag>Aag	p.E235K	MAGEA12_ENST00000393869.3_Missense_Mutation_p.E235K|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Missense_Mutation_p.E235K	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	235	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					ACACTGTCCTCCCTCCCATCA	0.562000													86	69					0	0	1	0	0
PFKFB4	5210	broad.mit.edu	37	3	48587373	48587373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48587373G>A	ENST00000232375.3	-	3	347	c.235C>T	c.(235-237)Cgc>Tgc	p.R79C	PFKFB4_ENST00000490115.1_5'UTR|PFKFB4_ENST00000416568.1_Missense_Mutation_p.R79C|PFKFB4_ENST00000545984.1_Missense_Mutation_p.R79C|PFKFB4_ENST00000536104.1_Missense_Mutation_p.R68C|PFKFB4_ENST00000541519.1_Missense_Mutation_p.R45C|PFKFB4_ENST00000383734.2_Missense_Mutation_p.R79C	NM_004567.2	NP_004558.1	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	79	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ACGTCCCGGCGATACTGGCCA	0.502000													25	59					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207767	58207767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58207767G>A	ENST00000377918.3	+	1	1113	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	363	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GGCGCTGAGCGAGGCCGCCCC	0.672000													21	52					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105404490	105404490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105404490G>A	ENST00000333244.5	-	7	17417	c.17298C>T	c.(17296-17298)tcC>tcT	p.S5766S	AHNAK2_ENST00000557457.1_Silent_p.S764S	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5766						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTCTTGCCGCGGATGTCACCA	0.542000													21	38					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158284011	158284011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:158284011G>A	ENST00000296526.7	+	15	2792	c.2467G>A	c.(2467-2469)Ggc>Agc	p.G823S	GRIA2_ENST00000449365.1_Missense_Mutation_p.G776S|GRIA2_ENST00000264426.9_Missense_Mutation_p.G823S|GRIA2_ENST00000393815.2_Missense_Mutation_p.G776S|GRIA2_ENST00000507898.1_Missense_Mutation_p.G776S	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	823					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CCTTGTCGGGGGCCTTGGTTT	0.453000													15	99					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44223502	44223502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44223502C>T	ENST00000249130.5	-	7	896	c.761G>A	c.(760-762)cGg>cAg	p.R254Q	SULT4A1_ENST00000330884.4_Intron|SULT4A1_ENST00000540422.1_Intron			Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	254					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GAAGATCTTCCGAGCAAAGAC	0.403000													6	32					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150840204	150840204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150840204C>T	ENST00000370357.4	+	13	1635	c.1390C>T	c.(1390-1392)Ctc>Ttc	p.L464F		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	464						nucleus	signal transducer activity	p.L464V(4)|p.L464F(2)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					ATCCAACTCTCTCAAAAACAC	0.463000													28	27					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	11905494	11905494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11905494C>T	ENST00000396373.4	+	2	418	c.144C>T	c.(142-144)atC>atT	p.I48I	ETV6_ENST00000544715.1_3'UTR	NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	48	PNT.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				AAGACTCGATCCGCCTGCCTG	0.622000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								22	56					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112167654	112167654	+	Nonsense_Mutation	SNP	C	C	T	rs146335507		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:112167654C>T	ENST00000455480.2	+	11	1558	c.1381C>T	c.(1381-1383)Cga>Tga	p.R461*	ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000392636.2_Nonsense_Mutation_p.R32*|ACAD10_ENST00000549590.1_Nonsense_Mutation_p.R430*|ACAD10_ENST00000313698.4_Nonsense_Mutation_p.R430*	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	430							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						TAAGCAGTATCGAGCTTCCGA	0.542000													16	55					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21805064	21805064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21805064C>T	ENST00000328843.6	+	56	9011	c.8980C>T	c.(8980-8982)Cca>Tca	p.P2994S	DNAH11_ENST00000409508.3_Missense_Mutation_p.P2987S			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2994	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GTGTTTCTCTCCAGTTGGTCG	0.502000									Kartagener syndrome				49	106					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192544995	192544995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:192544995G>A	ENST00000367459.3	+	1	139	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	RGS1_ENST00000469578.2_Missense_Mutation_p.E25K	NM_002922.3	NP_002913.3	Q08116	RGS1_HUMAN	regulator of G-protein signaling 1	25					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			kidney(8)|large_intestine(1)|lung(13)	22		Breast(1374;0.188)				TAACCCAAAGGAATTGAAAGG	0.418000													23	50					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269982	150269982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150269982G>A	ENST00000255945.2	+	3	999	c.824G>A	c.(823-825)aGa>aAa	p.R275K	GIMAP4_ENST00000461940.1_Missense_Mutation_p.R289K|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	275							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGGAAAAGAGAAAGAAGCAA	0.463000													20	49					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61413644	61413644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61413644G>A	ENST00000395348.3	-	5	1776	c.1140C>T	c.(1138-1140)atC>atT	p.I380I	SLC16A9_ENST00000395347.1_Silent_p.I380I	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	380					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						GGCCCATGATGATTAAGGTAG	0.418000													42	82					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111090583	111090583	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:111090583T>G	ENST00000262839.2	-	6	2377	c.1459A>C	c.(1459-1461)Att>Ctt	p.I487L		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	487					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GAACTTAAAATGTTGGATATT	0.463000													20	28					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17468993	17468993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17468993G>A	ENST00000400588.1	-	3	650	c.543C>T	c.(541-543)tgC>tgT	p.C181C	GAB4_ENST00000523144.1_Intron	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	181										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCTGATGGGAGCAGCTGGGCT	0.607000													13	21					0	0	1	0	0
IGHV3-73	28409	broad.mit.edu	37	14	107211030	107211030	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107211030C>T	ENST00000390636.2	-	0	338																											GTGAACCTGCCTTTCACCGAC	0.527000													40	123					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57425699	57425699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57425699C>T	ENST00000543257.1	-	3	653	c.87G>A	c.(85-87)aaG>aaA	p.K29K	C8B_ENST00000371237.4_Silent_p.K81K|C8B_ENST00000535057.1_5'UTR	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	81					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TTACCCTTTTCTTCTGACAGG	0.532000													15	29					0	0	1	0	0
FNDC5	252995	broad.mit.edu	37	1	33333418	33333418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33333418C>T	ENST00000373471.3	-	4	501	c.210G>A	c.(208-210)ggG>ggA	p.G70G		NM_001171940.1|NM_153756.2	NP_001165411.1|NP_715637.1	Q8NAU1	FNDC5_HUMAN	fibronectin type III domain containing 5	129	Fibronectin type-III.					integral to membrane|peroxisomal membrane				breast(1)|large_intestine(1)|lung(2)|ovary(1)	5		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GTTGGTTCCTCCCCATCTCTT	0.567000													15	57					0	0	1	0	0
PROC	5624	broad.mit.edu	37	2	128178990	128178990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128178990G>A	ENST00000453608.2	+	3	273	c.265G>A	c.(265-267)Gag>Aag	p.E89K	PROC_ENST00000422777.3_Missense_Mutation_p.E68K|PROC_ENST00000234071.3_Missense_Mutation_p.E68K|PROC_ENST00000409048.1_Missense_Mutation_p.E68K			P04070	PROC_HUMAN	protein C (inactivator of coagulation factors Va and VIIIa)	68			G -> C (in patients with PROC deficiency).		blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	TGACTTCGAGGAGGCCAAGGA	0.587000													17	40					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43947855	43947855	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43947855G>A	ENST00000282406.4	+	16	2618	c.2508G>A	c.(2506-2508)aaG>aaA	p.K836K		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	836	PH 2.					cytoplasm|cytoskeleton|integral to membrane	binding	p.K836N(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TAATAGGAAAGACATTATATT	0.323000													59	152					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73484039	73484039	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73484039C>T	ENST00000314256.7	+	6	830	c.436C>T	c.(436-438)Cag>Tag	p.Q146*	KIAA0195_ENST00000583795.1_3'UTR|KIAA0195_ENST00000579208.1_Intron|KIAA0195_ENST00000375248.5_Nonsense_Mutation_p.Q156*	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	146					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGGGAGATCCAGTGGCCCAG	0.597000													14	48					0	0	1	0	0
NAT6	24142	broad.mit.edu	37	3	50334221	50334221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50334221G>A	ENST00000443842.1	-	2	1481	c.674C>T	c.(673-675)cCa>cTa	p.P225L	NAT6_ENST00000443094.2_Missense_Mutation_p.P225L|NAT6_ENST00000417393.1_Missense_Mutation_p.P225L|HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000450982.1_Intron|NAT6_ENST00000354862.4_Missense_Mutation_p.P247L|HYAL3_ENST00000415204.1_Intron|HYAL3_ENST00000359051.3_Intron|HYAL3_ENST00000336307.1_Intron					N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		AGTCAGGTTTGGGGCCTTCCT	0.662000													20	43					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108112947	108112947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108112947C>T	ENST00000273353.3	-	37	5306	c.5250G>A	c.(5248-5250)caG>caA	p.Q1750Q		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1750						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CAGCTTCTTTCTGCATCCGGG	0.488000													51	82					0	0	1	0	0
SERPINI1	5274	broad.mit.edu	37	3	167512518	167512518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167512518C>T	ENST00000295777.5	+	5	1218	c.787C>T	c.(787-789)Cct>Tct	p.P263S	SERPINI1_ENST00000446050.2_Missense_Mutation_p.P263S	NM_005025.4	NP_005016.1	Q99574	NEUS_HUMAN	serpin peptidase inhibitor, clade I (neuroserpin), member 1	263					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(7)|skin(2)	20						ACAGGAAGTTCCTCTTGCTAC	0.448000													23	42					0	0	1	0	0
OR7E24	26648	broad.mit.edu	37	19	9361945	9361945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9361945C>T	ENST00000456448.1	+	1	340	c.226C>T	c.(226-228)Ccc>Tcc	p.P76S		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						CCTCCACACCCCCATGTACTT	0.577000													21	76					0	0	1	0	0
HAP1	9001	broad.mit.edu	37	17	39888301	39888301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39888301C>T	ENST00000393939.2	-	4	793	c.784G>A	c.(784-786)Gag>Aag	p.E262K	HAP1_ENST00000347901.4_Missense_Mutation_p.E262K|HAP1_ENST00000310778.5_Missense_Mutation_p.E262K|HAP1_ENST00000341193.5_Missense_Mutation_p.E270K|JUP_ENST00000540235.1_Intron			P54257	HAP1_HUMAN	huntingtin-associated protein 1	262	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			tcctcatcctcctcATCAGAA	0.512000													12	19					0	0	1	0	0
NUDT21	11051	broad.mit.edu	37	16	56481894	56481894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56481894G>A	ENST00000300291.5	-	2	296	c.124C>T	c.(124-126)Ctt>Ttt	p.L42F		NM_007006.2	NP_008937.1	O43809	CPSF5_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 21	42	Necessary for RNA-binding.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	centrosome|mRNA cleavage factor complex|paraspeckles	AU-rich element binding|histone deacetylase binding|hydrolase activity|mRNA binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)	7						TAATTGGTAAGAGGGTACCTG	0.393000													7	38					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	402001	402001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:402001G>A	ENST00000256509.2	+	12	1842	c.1200G>A	c.(1198-1200)agG>agA	p.R400R	CHL1_ENST00000397491.2_Silent_p.R384R	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	384	Ig-like C2-type 4.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TCTTCCCCAGGGAAATCAGTT	0.378000													29	109					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48736725	48736725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48736725G>A	ENST00000285238.8	+	7	882	c.802G>A	c.(802-804)Gca>Aca	p.A268T	ABCC3_ENST00000427699.1_Missense_Mutation_p.A268T	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	268					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AAAGCAGACGGCACGGTGAGG	0.622000													21	69					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38187400	38187400	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:38187400G>A	ENST00000317025.8	-	6	1594	c.1077C>T	c.(1075-1077)ccC>ccT	p.P359P	WHSC1L1_ENST00000433384.2_Silent_p.P359P|WHSC1L1_ENST00000316985.3_Silent_p.P359P|WHSC1L1_ENST00000527502.1_Silent_p.P359P	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	359					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TCTGAGGTCGGGGTTTCCGAA	0.363000			T	NUP98	AML								21	74					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16735650	16735650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16735650C>T	ENST00000335496.1	-	7	1118	c.636G>A	c.(634-636)gaG>gaA	p.E212E	SPATA21_ENST00000540400.1_Silent_p.E189E|SPATA21_ENST00000466212.1_5'UTR	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	212							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		CCTCGGACTTCTCCCGGTTTT	0.612000													24	54					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47511092	47511092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47511092G>A	ENST00000285039.7	-	8	1241	c.942C>T	c.(940-942)ctC>ctT	p.L314L		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	314	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CCTTACCGAGGAGTGTGAAGG	0.552000													23	62					0	0	1	0	0
ATP6V0A2	23545	broad.mit.edu	37	12	124239059	124239059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124239059C>T	ENST00000330342.3	+	18	2516	c.2268C>T	c.(2266-2268)ctC>ctT	p.L756L	ATP6V0A2_ENST00000544833.1_Silent_p.L38L	NM_012463.3	NP_036595.2	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a2	756					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		ACCTGAGGCTCTGGGCGCTTA	0.507000													13	59					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27736193	27736193	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27736193G>A	ENST00000430629.2	-	8	1547	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	WASF2_ENST00000536657.1_Intron	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	444	WH2.				actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TACCTTGACGGATGGCTGAAA	0.572000													20	78					0	0	1	0	0
IL27	246778	broad.mit.edu	37	16	28513323	28513323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28513323C>T	ENST00000356897.1	-	4	458	c.436G>A	c.(436-438)Gat>Aat	p.D146N		NM_145659.3	NP_663634.2	Q8NEV9	IL27A_HUMAN	interleukin 27	146					inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	10						CGCTGCAGATCGCGGAGGTCC	0.652000													27	81					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031894	32031894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:32031894C>T	ENST00000360311.4	+	2	1872	c.1323C>T	c.(1321-1323)ctC>ctT	p.L441L		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	441					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						GTTCATATCTCGTAGTTCATT	0.378000													28	57					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020752	5020752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5020752C>T	ENST00000321543.1	+	1	540	c.540C>T	c.(538-540)ttC>ttT	p.F180F		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCACGCCTTCTGTTTGCACC	0.473000													21	116					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6174985	6174985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6174985C>T	ENST00000264870.3	-	12	1840	c.1575G>A	c.(1573-1575)gtG>gtA	p.V525V		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	525					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CAGCATTTTCCACTTCAAAGT	0.478000													24	42					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16962338	16962338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16962338C>T	ENST00000379803.1	+	6	856	c.842C>T	c.(841-843)cCc>cTc	p.P281L	SIN3B_ENST00000596802.1_Missense_Mutation_p.P281L|SIN3B_ENST00000248054.5_Missense_Mutation_p.P281L	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	281					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						GTGTCTGCACCCGCCAAGGTA	0.672000													14	70					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	124012331	124012331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124012331C>T	ENST00000456829.2	+	16	2157	c.1906C>T	c.(1906-1908)Cgt>Tgt	p.R636C	VWA5A_ENST00000360334.4_Silent_p.T397T|VWA5A_ENST00000392748.1_Missense_Mutation_p.R636C	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	636										autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						ACACTCTGACCGTCCTCCTTC	0.468000													50	107					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117686752	117686752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117686752G>A	ENST00000368508.3	-	19	3163	c.2965C>T	c.(2965-2967)Cat>Tat	p.H989Y	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.H984Y	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	989	Fibronectin type-III 4.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ACCTTAGAATGAGCACTAAAT	0.423000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								24	42					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211438116	211438116	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211438116A>T	ENST00000233072.5	+	2	417	c.221A>T	c.(220-222)aAt>aTt	p.N74I	CPS1_ENST00000430249.2_Missense_Mutation_p.N80I	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	74	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GTGGTTTTTAATACTGGCCTG	0.433000													21	93					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56057844	56057844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56057844C>T	ENST00000313022.2	-	1	722	c.695G>A	c.(694-696)gGa>gAa	p.G232E		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					TTTCTGCTTTCCTGAAGTGGA	0.383000													48	100					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10434094	10434094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10434094G>A	ENST00000293677.6	-	4	1037	c.956C>T	c.(955-957)cCc>cTc	p.P319L		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	302	Interaction with PTBP1 (By similarity).					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			ACTGCGGCCGGGGGGCCCAGG	0.711000													4	20					0	0	1	0	0
USP41	373856	broad.mit.edu	37	22	20729877	20729877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20729877G>A	ENST00000454608.2	-	6	302	c.303C>T	c.(301-303)ttC>ttT	p.F101F						ubiquitin specific peptidase 41											endometrium(1)|kidney(1)|lung(2)|skin(1)	5						GAAGCATCTGGAAAGGGACGC	0.572000													4	22					0	0	1	0	0
SPP2	6694	broad.mit.edu	37	2	234975199	234975199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234975199G>A	ENST00000168148.3	+	5	555	c.467G>A	c.(466-468)gGa>gAa	p.G156E	SPP2_ENST00000373368.1_Missense_Mutation_p.G156E	NM_006944.2	NP_008875.1	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa	156					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		GACATGTTGGGATCTCATAAA	0.308000													42	105					0	0	1	0	0
OR52B6	340980	broad.mit.edu	37	11	5602589	5602589	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5602589G>A	ENST00000345043.2	+	1	483	c.483G>A	c.(481-483)ggG>ggA	p.G161G	HBG2_ENST00000380259.2_Intron|AC015691.13_ENST00000394793.2_RNA	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGTCATTGGGAAGATCGTCA	0.512000													72	203					0	0	1	0	0
MIR587	693172	broad.mit.edu	37	6	107232091	107232091	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:107232091C>T	ENST00000384845.1	+	0	92					NR_030314.1																						aagcccatcccatatcccacc	0.547000													16	32					0	0	1	0	0
FBLIM1	54751	broad.mit.edu	37	1	16091552	16091552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16091552C>T	ENST00000375766.3	+	3	714	c.74C>T	c.(73-75)gCc>gTc	p.A25V	FBLIM1_ENST00000375771.1_Missense_Mutation_p.A25V|FBLIM1_ENST00000332305.5_Missense_Mutation_p.A25V|FBLIM1_ENST00000441801.2_Missense_Mutation_p.A25V|FBLIM1_ENST00000400773.1_Missense_Mutation_p.A25V	NM_017556.2	NP_060026.2	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	25	Filamin-binding.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		CGCGATGTGGCCGTGGCGGAG	0.672000													47	86					0	0	1	0	0
C11orf42	160298	broad.mit.edu	37	11	6231278	6231278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6231278G>A	ENST00000316375.2	+	2	321	c.271G>A	c.(271-273)Ggt>Agt	p.G91S		NM_173525.2	NP_775796.2	Q8N5U0	CK042_HUMAN	chromosome 11 open reading frame 42	91										endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|soft_tissue(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGATCTGAGGGTGCCTTCGC	0.622000													19	45					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74003537	74003537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74003537C>T	ENST00000301607.3	-	22	6002	c.5749G>A	c.(5749-5751)Gtg>Atg	p.V1917M	EVPL_ENST00000586740.1_Missense_Mutation_p.V1939M	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1917	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCCTCGCCCACCGAGAGCCTC	0.662000													9	61					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68396094	68396094	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68396094C>T	ENST00000297770.4	-	8	963		c.e8-1		CPA6_ENST00000518549.1_Splice_Site|CPA6_ENST00000297769.4_Splice_Site	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6						proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			AAAATCGATCCTAGACATAAT	0.398000													48	154					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115964637	115964637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115964637G>A	ENST00000251864.2	+	10	1435	c.1282G>A	c.(1282-1284)Gag>Aag	p.E428K	TDRD1_ENST00000369281.2_Missense_Mutation_p.E428K|TDRD1_ENST00000369282.1_Missense_Mutation_p.E428K|TDRD1_ENST00000369280.1_Missense_Mutation_p.E428K|TDRD1_ENST00000422662.1_Missense_Mutation_p.E89K	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	428					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGTAGAAGTTGAGCTGCCAAA	0.383000													28	72					0	0	1	0	0
G6PC2	57818	broad.mit.edu	37	2	169759040	169759040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169759040C>T	ENST00000375363.3	+	2	396	c.304C>T	c.(304-306)Cct>Tct	p.P102S	SPC25_ENST00000472216.2_Intron|G6PC2_ENST00000421979.1_Intron|G6PC2_ENST00000429379.2_Missense_Mutation_p.P102S	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	102					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						TGAACAGTTCCCTACTACATG	0.403000													40	74					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38704876	38704876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38704876G>A	ENST00000359357.3	+	4	399	c.145G>A	c.(145-147)Gga>Aga	p.G49R	DNAH8_ENST00000449981.2_Missense_Mutation_p.G266R|DNAH8_ENST00000441566.1_Missense_Mutation_p.G49R					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGCGTCGAAAGGACTCTTAAA	0.398000													31	92					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36933542	36933542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36933542G>A	ENST00000373103.1	-	14	2292	c.1745C>T	c.(1744-1746)tCc>tTc	p.S582F	CSF3R_ENST00000440588.2_Missense_Mutation_p.S582F|CSF3R_ENST00000331941.5_Missense_Mutation_p.S582F|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000373106.1_Missense_Mutation_p.S582F|CSF3R_ENST00000361632.4_Missense_Mutation_p.S582F|CSF3R_ENST00000373104.1_Missense_Mutation_p.S582F|CSF3R_ENST00000418048.2_Missense_Mutation_p.S582F|CSF3R_ENST00000338937.5_Missense_Mutation_p.S582F	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	582	Fibronectin type-III 5.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	AAAGCCACGGGAGGAGGCATT	0.632000													10	55					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17675478	17675478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17675478G>A	ENST00000262077.2	-	4	704	c.705C>T	c.(703-705)gcC>gcT	p.A235A	NUP153_ENST00000537253.1_Silent_p.A235A	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	235					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GTGTTCCAAAGGCAGACAAGT	0.408000													25	74					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56081758	56081758	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56081758C>T	ENST00000257880.7	-	25	3531	c.3312G>A	c.(3310-3312)tgG>tgA	p.W1104*	ITGA7_ENST00000553804.1_Nonsense_Mutation_p.W1064*|ITGA7_ENST00000394229.2_Nonsense_Mutation_p.W1060*|ITGA7_ENST00000394230.2_Nonsense_Mutation_p.W1064*|ITGA7_ENST00000347027.6_Nonsense_Mutation_p.W1054*|ITGA7_ENST00000257879.6_Nonsense_Mutation_p.W1060*|ITGA7_ENST00000555728.1_Nonsense_Mutation_p.W1104*|ITGA7_ENST00000452168.2_Nonsense_Mutation_p.W967*			Q13683	ITA7_HUMAN	integrin, alpha 7	1104					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCCTCACCTTCCACAGGAGCA	0.592000													49	151					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80623121	80623121	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80623121C>T	ENST00000458043.2	+	7	553	c.547C>T	c.(547-549)Cga>Tga	p.R183*	OTOGL_ENST00000547103.1_Nonsense_Mutation_p.R183*	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						AGAGGAAATTCGAATTTATGG	0.348000													24	46					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35381118	35381118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35381118C>T	ENST00000378495.3	+	18	2372	c.2150C>T	c.(2149-2151)gCc>gTc	p.A717V	UNC13B_ENST00000378496.4_Missense_Mutation_p.A717V|UNC13B_ENST00000396787.1_Missense_Mutation_p.A729V	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	717					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GACAAATCAGCCGTCTCAGGG	0.488000													6	34					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145246231	145246231	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145246231G>A	ENST00000377976.1	-	2	396	c.397C>T	c.(397-399)Cga>Tga	p.R133*		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	133								p.R133*(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						ATTGGGGTTCGAATGATTTTC	0.398000													36	88					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95790940	95790940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95790940G>A	ENST00000260766.3	+	2	771	c.137G>A	c.(136-138)cGa>cAa	p.R46Q	PLCE1_ENST00000371380.2_Missense_Mutation_p.R46Q	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	46					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				ACTGTCAGACGAAGTGGGGAG	0.433000													34	97					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104048451	104048451	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104048451G>A	ENST00000374874.3	+	4	757	c.318G>A	c.(316-318)gaG>gaA	p.E106E	LPPR1_ENST00000395056.2_Silent_p.E106E	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		106						integral to membrane	catalytic activity										TTGCTCAGGAGAAAACAATTC	0.388000													14	101					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75017841	75017841	+	Missense_Mutation	SNP	G	G	A	rs147534770		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75017841G>A	ENST00000261978.4	-	7	1998	c.1612C>T	c.(1612-1614)Cgg>Tgg	p.R538W	LTBP2_ENST00000556690.1_Missense_Mutation_p.R538W|LTBP2_ENST00000557425.1_5'UTR	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	538					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGCAGTGGCCGAGGGGGCTCT	0.667000													15	51					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90016808	90016808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90016808G>A	ENST00000405460.2	+	45	9776	c.9680G>A	c.(9679-9681)cGa>cAa	p.R3227Q		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3227					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AATGTATCTCGAACTAATGGC	0.393000													51	114					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241262032	241262032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:241262032C>T	ENST00000366565.1	-	3	490	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	RGS7_ENST00000407727.1_Missense_Mutation_p.E37K|RGS7_ENST00000401882.1_Missense_Mutation_p.E37K|RGS7_ENST00000348120.2_Missense_Mutation_p.E37K|RGS7_ENST00000366562.4_Missense_Mutation_p.E37K|RGS7_ENST00000366563.1_Missense_Mutation_p.E37K|RGS7_ENST00000366564.1_Missense_Mutation_p.E37K|RGS7_ENST00000331110.7_Missense_Mutation_p.E11K|RGS7_ENST00000446183.2_5'UTR	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	37	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CCATTTTTTTCATCTTGCATC	0.348000													22	37					0	0	1	0	0
CCDC74A	90557	broad.mit.edu	37	2	132288272	132288272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132288272C>T	ENST00000467992.2	+	1	1036	c.722C>T	c.(721-723)tCc>tTc	p.S241F	CCDC74A_ENST00000295171.6_Missense_Mutation_p.S139F|CCDC74A_ENST00000409856.3_Intron			Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	139										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						AAGGAGGGCTCCTCACGGACA	0.662000													21	92					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93125602	93125602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93125602C>T	ENST00000216487.7	+	7	2282	c.2123C>T	c.(2122-2124)tCg>tTg	p.S708L	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	708	Interaction with RAB5B.|VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding	p.S708L(2)		endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				AAGGATGGTTCGCTGCAGCAG	0.547000													56	200					0	0	1	0	0
LFNG	3955	broad.mit.edu	37	7	2559870	2559870	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2559870C>T	ENST00000222725.5	+	1	395	c.375C>T	c.(373-375)ttC>ttT	p.F125F	LFNG_ENST00000359574.3_Silent_p.F125F|LFNG_ENST00000402506.1_Intron|LFNG_ENST00000402045.1_Intron|LFNG_ENST00000338732.3_Intron	NM_001040167.1	NP_001035257.1	Q8NES3	LFNG_HUMAN	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	125					organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)|urinary_tract(2)	6		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		CCAAAAAGTTCCACCGCGCGC	0.751000													16	47					0	0	1	0	0
RNF125	54941	broad.mit.edu	37	18	29645969	29645969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29645969C>T	ENST00000217740.3	+	5	1101	c.609C>T	c.(607-609)ttC>ttT	p.F203F	RNF125_ENST00000583384.1_3'UTR|RP11-53I6.2_ENST00000583184.1_RNA	NM_017831.3	NP_060301.2	Q96EQ8	RN125_HUMAN	ring finger protein 125, E3 ubiquitin protein ligase	203					negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						ATGATGATTTCATAGTAAGTA	0.328000													34	82					0	0	1	0	0
NUTM2A	728118	broad.mit.edu	37	10	88988177	88988177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88988177C>T	ENST00000381689.4	+	2	871	c.540C>T	c.(538-540)acC>acT	p.T180T	NUTM2A-AS1_ENST00000451940.2_RNA|NUTM2A_ENST00000381707.2_Silent_p.T180T					NUT family member 2A																		TGCTGTCTACCCTCCCCAGCA	0.677000													28	183					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207639872	207639872	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207639872G>A	ENST00000367057.3	+	2	249	c.58_splice	c.e2-1	p.G20_splice	CR2_ENST00000367059.3_Splice_Site_p.G20_splice|CR2_ENST00000458541.2_Splice_Site_p.G20_splice|CR2_ENST00000367058.3_Splice_Site_p.G20_splice	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	20					complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						ACTTTTCAGGGATTTCTTGTG	0.383000													66	186					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2211187	2211187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2211187C>T	ENST00000398665.3	+	15	1477	c.1441C>T	c.(1441-1443)Ccg>Tcg	p.P481S		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	481						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGCCCACCCCGCCCGCGCT	0.677000													29	68					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819490	43819490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43819490G>A	ENST00000382031.1	+	5	6564	c.6533G>A	c.(6532-6534)aGc>aAc	p.S2178N	MAP1A_ENST00000300231.5_Missense_Mutation_p.S1940N|MAP1A_ENST00000399453.1_Missense_Mutation_p.S1940N			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1940						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GCCAGCAAAAGCCATGCCACC	0.547000													37	73					0	0	1	0	0
AGMAT	79814	broad.mit.edu	37	1	15905504	15905504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15905504C>T	ENST00000375826.3	-	4	712	c.570G>A	c.(568-570)acG>acA	p.T190T	DNAJC16_ENST00000483270.1_Intron	NM_024758.4	NP_079034.3	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase)	190					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(2)|skin(1)	12		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		CCTTGTCGGTCGTGTCCGTGT	0.642000													15	46					0	0	1	0	0
ZNF414	84330	broad.mit.edu	37	19	8576620	8576620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8576620G>A	ENST00000393927.4	-	5	868	c.755C>T	c.(754-756)cCg>cTg	p.P252L	ZNF414_ENST00000255616.8_Missense_Mutation_p.P252L	NM_001146175.1	NP_001139647.1	Q96IQ9	ZN414_HUMAN	zinc finger protein 414	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(2)	2						GGGCAGGAACGGTCCGGTGGG	0.766000													3	4					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76828852	76828852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76828852C>T	ENST00000248598.5	-	1	291	c.259G>A	c.(259-261)Gaa>Aaa	p.E87K	CCDC146_ENST00000431197.1_Intron|CCDC146_ENST00000285871.4_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	87					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						TTTACGATTTCCTTGAGGTTT	0.507000													31	88					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413062	124413062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124413062C>T	ENST00000306842.2	-	1	513	c.489G>A	c.(487-489)atG>atA	p.M163I		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		AGGTCAGGTTCATTATGCTTC	0.502000													33	81					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22211865	22211865	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22211865G>A	ENST00000374695.3	-	10	1237	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	386	LDL-receptor class A 4.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGTCACAGTGGAAGCTGGCTG	0.627000													11	49					0	0	1	0	0
USP2	9099	broad.mit.edu	37	11	119228486	119228486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119228486G>A	ENST00000260187.2	-	10	1776	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	USP2_ENST00000455332.2_Silent_p.F251F|USP2_ENST00000525735.1_Silent_p.F285F	NM_004205.4	NP_004196.4	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2	494	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	24		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		AGATCTTTGGGAACCTCTGGA	0.498000													167	402					0	0	1	0	0
EGR1	1958	broad.mit.edu	37	5	137802597	137802597	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137802597C>T	ENST00000239938.4	+	2	731	c.459C>T	c.(457-459)ccC>ccT	p.P153P		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	153					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GGCCCGAGCCCCTCTTCAGCT	0.637000													45	131					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542280	55542280	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55542280C>T	ENST00000220676.1	+	4	5986	c.5838C>T	c.(5836-5838)ttC>ttT	p.F1946F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1946					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGAAAATTTCTTGGGTTTTT	0.343000													22	98					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584325	82584325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82584325C>T	ENST00000423517.2	-	5	6281	c.5944G>A	c.(5944-5946)Gga>Aga	p.G1982R	PCLO_ENST00000333891.8_Missense_Mutation_p.G1982R	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1913					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGCATAAATCCATTTTCTTCT	0.363000													37	158					0	0	1	0	0
ASPG	374569	broad.mit.edu	37	14	104565220	104565220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104565220C>T	ENST00000551177.1	+	6	636	c.544C>T	c.(544-546)Cgg>Tgg	p.R182W	ASPG_ENST00000546892.2_Missense_Mutation_p.R182W|ASPG_ENST00000455920.2_Missense_Mutation_p.R182W	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	182	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						TCAGCTGTTTCGGGGCAACCG	0.607000													5	24					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112031331	112031331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112031331C>T	ENST00000369716.4	-	3	906	c.773G>A	c.(772-774)gGa>gAa	p.G258E	ADORA3_ENST00000369717.4_Missense_Mutation_p.G177E	NM_020683.6	NP_065734.5	P33765	AA3R_HUMAN	adenosine A3 receptor	0					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GGCCAGGGTTCCTTTGTCGTC	0.537000													8	40					0	0	1	0	0
TFCP2	7024	broad.mit.edu	37	12	51512411	51512411	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51512411G>A	ENST00000307660.4	-	2	987	c.267C>T	c.(265-267)ctC>ctT	p.L89L	TFCP2_ENST00000257915.5_Silent_p.L89L|TFCP2_ENST00000549867.1_Silent_p.L89L|TFCP2_ENST00000548115.1_Silent_p.L89L	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	89					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						AACCTTGATTGAGATACGTTA	0.393000													11	114					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306738	41306738	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:41306738G>A	ENST00000373198.3	-	7	1156	c.921C>T	c.(919-921)atC>atT	p.I307I	PTPRT_ENST00000373193.3_Silent_p.I307I|PTPRT_ENST00000373184.1_Silent_p.I307I|PTPRT_ENST00000373201.1_Silent_p.I307I|PTPRT_ENST00000373190.1_Silent_p.I307I|PTPRT_ENST00000373187.1_Silent_p.I307I|PTPRT_ENST00000356100.2_Silent_p.I307I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	307	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CATTTGGCTTGATCCACAGGT	0.552000													11	36					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100395072	100395072	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100395072G>A	ENST00000542585.1	+	0	8561				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCATTTACAGAACGAGGAGG	0.622000													17	51					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70530546	70530546	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70530546G>A	ENST00000357887.3	-	3	2638	c.1885C>T	c.(1885-1887)Cag>Tag	p.Q629*	SLC8A3_ENST00000534137.1_Intron|SLC8A3_ENST00000394330.2_Intron|SLC8A3_ENST00000216568.7_Intron|SLC8A3_ENST00000528359.1_Nonsense_Mutation_p.Q629*|SLC8A3_ENST00000356921.2_Intron|SLC8A3_ENST00000533541.1_Intron|SLC8A3_ENST00000381269.2_Intron	NM_033262.3	NP_150287.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	628					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ACACCTTTCTGAAAACTCATA	0.423000													8	83					0	0	1	0	0
NMU	10874	broad.mit.edu	37	4	56471487	56471487	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:56471487G>A	ENST00000264218.3	-	7	495	c.390C>T	c.(388-390)ctC>ctT	p.L130L	NMU_ENST00000505262.1_Silent_p.L103L|NMU_ENST00000511469.1_Silent_p.L114L|NMU_ENST00000515325.1_5'UTR|NMU_ENST00000507338.1_Intron	NM_006681.2	NP_006672.1	P48645	NMU_HUMAN	neuromedin U	130					neuropeptide signaling pathway	extracellular region				lung(3)|ovary(1)|urinary_tract(1)	5	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		GGTGAGGAACGAGCTGCAGCA	0.502000													29	83					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163510	32163510	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32163510G>A	ENST00000564145.1	-	0	65																											TGCCCTTCGGGGTGATGCCAG	0.547000													10	78					0	0	1	0	0
GABRR2	2570	broad.mit.edu	37	6	89975401	89975401	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:89975401G>A	ENST00000402938.3	-	7	953	c.820C>T	c.(820-822)Ctg>Ttg	p.L274L	GABRR2_ENST00000602399.1_Silent_p.L299L			P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	299					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		ATGACCATCAGAGTGGCAGGG	0.512000													33	38					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51749832	51749832	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51749832C>T	ENST00000395052.3	+	4	2277	c.2043C>T	c.(2041-2043)gcC>gcT	p.A681A	GRM2_ENST00000442933.2_Intron|GRM2_ENST00000475478.1_3'UTR	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	681					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CACAGGTGGCCATCTGCCTGG	0.677000													9	39					0	0	1	0	0
MTFR1	9650	broad.mit.edu	37	8	66620087	66620087	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:66620087A>G	ENST00000262146.4	+	7	900	c.774A>G	c.(772-774)caA>caG	p.Q258Q	MTFR1_ENST00000458689.2_Silent_p.Q225Q|MTFR1_ENST00000517944.1_3'UTR	NM_014637.3	NP_055452.3	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1	258						mitochondrion|plasma membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(1)|pancreas(1)|urinary_tract(1)	11			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			GGTCAGAGCAAGATGTGAAGC	0.488000													17	64					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32233121	32233121	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32233121T>G	ENST00000400246.1	+	26	2476	c.2334T>G	c.(2332-2334)ctT>ctG	p.L778L	DEPDC5_ENST00000400248.1_Silent_p.L769L|DEPDC5_ENST00000535622.1_Silent_p.L700L|DEPDC5_ENST00000382111.2_Silent_p.L778L|DEPDC5_ENST00000400249.2_Silent_p.L769L|DEPDC5_ENST00000266091.3_Silent_p.L778L|DEPDC5_ENST00000382105.2_Silent_p.L700L|DEPDC5_ENST00000382112.3_Silent_p.L769L			O75140	DEPD5_HUMAN	DEP domain containing 5	769					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ATGATCTCCTTCCAGAAGCAG	0.532000													8	88					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155199125	155199125	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155199125G>A	ENST00000460012.1	-	23	4957	c.4600C>T	c.(4600-4602)Cgg>Tgg	p.R1534W	PLCH1_ENST00000334686.6_Missense_Mutation_p.R1534W|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000340059.7_Missense_Mutation_p.R1572W|PLCH1_ENST00000414191.1_Missense_Mutation_p.R1534W			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1572					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			ACCAGTGCCCGGGGGAGCTGA	0.512000													23	98					0	0	1	0	0
LBR	3930	broad.mit.edu	37	1	225609926	225609926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:225609926G>A	ENST00000338179.2	-	3	344	c.219C>T	c.(217-219)tcC>tcT	p.S73S	LBR_ENST00000272163.4_Silent_p.S73S	NM_194442.2	NP_919424.1	Q14739	LBR_HUMAN	lamin B receptor	73	Nucleoplasmic (Potential).				cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		CTCGGCGTCTGGAAGGGGAAC	0.532000													8	77					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130281490	130281490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130281490C>T	ENST00000257359.6	-	6	2278	c.1572G>A	c.(1570-1572)gtG>gtA	p.V524V		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	524	Disintegrin.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CTCCATCTGCCACGGGCTGCA	0.582000													16	47					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581300	234581300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234581300G>A	ENST00000354728.4	+	1	802	c.720G>A	c.(718-720)acG>acA	p.T240T	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		CACCTGTTACGGAGTATGATC	0.428000													171	445					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48936161	48936161	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48936161C>T	ENST00000294954.7	-	8	627	c.605_splice	c.e8-1	p.L202_splice	STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Splice_Site_p.L202_splice|LHCGR_ENST00000401907.1_Splice_Site_p.L202_splice|LHCGR_ENST00000403273.1_Splice_Site_p.L202_splice|LHCGR_ENST00000344775.3_Splice_Site_p.L202_splice	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	202					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	CCTTTAGCTCCCTGTGGGGAA	0.488000													28	86					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75818801	75818801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:75818801C>T	ENST00000322507.8	-	52	8342	c.8033G>A	c.(8032-8034)gGa>gAa	p.G2678E	COL12A1_ENST00000345356.6_Missense_Mutation_p.G1514E|COL12A1_ENST00000483888.2_Missense_Mutation_p.G2678E|COL12A1_ENST00000416123.2_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2678	Nonhelical region (NC3).|TSP N-terminal.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength	p.G2678V(1)		breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TGTTATATTTCCAGCTTCCTT	0.323000													6	72					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625528	140625528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140625528G>A	ENST00000231173.3	+	1	382	c.382G>A	c.(382-384)Gat>Aat	p.D128N		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		128	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGACATAAACGATCATTCTCC	0.438000													57	143					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17091331	17091331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17091331G>A	ENST00000443236.1	-	14	1733	c.1702C>T	c.(1702-1704)Cgt>Tgt	p.R568C	CPAMD8_ENST00000388925.4_Intron	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	521						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TGTGTTAAACGAATCGGTTTC	0.592000													16	77					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098545	144098545	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:144098545G>A	ENST00000467773.1	-	4	437	c.438C>T	c.(436-438)gtC>gtT	p.V146V	NOBOX_ENST00000223140.5_Silent_p.V61V|NOBOX_ENST00000483238.1_Silent_p.V146V	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	146					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					CTTCTCCAGAGACTGCTGGCG	0.647000													19	35					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33502596	33502596	+	Silent	SNP	G	G	A	rs144422380		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:33502596G>A	ENST00000265371.4	-	10	1857	c.1332C>T	c.(1330-1332)gaC>gaT	p.D444D	NRP1_ENST00000374821.5_Silent_p.D444D|NRP1_ENST00000374823.5_Silent_p.D444D|RP11-342D11.2_ENST00000451530.1_RNA|NRP1_ENST00000374867.2_Silent_p.D444D|NRP1_ENST00000395995.1_Silent_p.D444D|NRP1_ENST00000374822.4_Silent_p.D444D|NRP1_ENST00000374816.3_Silent_p.D444D			O14786	NRP1_HUMAN	neuropilin 1	444	F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	TGATCTGGGAGTCAGAAATAA	0.493000													8	122					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158254056	158254056	+	Missense_Mutation	SNP	G	G	A	rs142538282	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:158254056G>A	ENST00000296526.7	+	7	1293	c.968G>A	c.(967-969)cGa>cAa	p.R323Q	GRIA2_ENST00000449365.1_Missense_Mutation_p.R276Q|GRIA2_ENST00000264426.9_Missense_Mutation_p.R323Q|GRIA2_ENST00000393815.2_Missense_Mutation_p.R276Q|GRIA2_ENST00000507898.1_Missense_Mutation_p.R276Q	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	323					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GAAATCTCCCGAAGGGGGAAT	0.478000													18	88					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230746	56230746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56230746G>A	ENST00000279791.1	-	1	131	c.132C>T	c.(130-132)atC>atT	p.I44I		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					TAATCAAAATGATCATACCAA	0.473000													16	47					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55939046	55939046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55939046C>T	ENST00000244728.5	-	20	2346	c.1949G>A	c.(1948-1950)gGa>gAa	p.G650E	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Missense_Mutation_p.G50E|COL21A1_ENST00000535941.1_Missense_Mutation_p.G650E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G647E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	650	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TCCCGGTGTTCCAGGCTGGCC	0.323000													34	105					0	0	1	0	0
PODXL	5420	broad.mit.edu	37	7	131191022	131191022	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131191022C>T	ENST00000541194.1	-	7	1571	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K	PODXL_ENST00000378555.3_Silent_p.K436K|PODXL_ENST00000322985.9_Silent_p.K404K|PODXL_ENST00000537928.1_Silent_p.K404K	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	436					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					CGCTTACCTCCTTTAGTTCAT	0.607000													50	116					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99441587	99441587	+	Silent	SNP	G	G	A	rs141454693	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:99441587G>A	ENST00000287042.4	+	2	1730	c.1380G>A	c.(1378-1380)acG>acA	p.T460T	KCNS2_ENST00000521839.1_Silent_p.T460T	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	460						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CAAGCCTGACGAACATGAGCA	0.493000													40	82					0	0	1	0	0
LBX1	10660	broad.mit.edu	37	10	102987154	102987154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102987154C>T	ENST00000370193.2	-	2	1697	c.719G>A	c.(718-720)gGc>gAc	p.G240D		NM_006562.4	NP_006553.2	P52954	LBX1_HUMAN	ladybird homeobox 1	240					muscle organ development		sequence-specific DNA binding			large_intestine(2)|lung(4)|ovary(1)	7		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		CTTCGGGGCGCCTGGGGGGAG	0.756000													7	19					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57929968	57929968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57929968G>A	ENST00000574161.1	+	9	1128	c.1009G>A	c.(1009-1011)Gaa>Aaa	p.E337K	GCOM1_ENST00000396180.1_Missense_Mutation_p.E306K|GCOM1_ENST00000380560.2_Missense_Mutation_p.E268K|GCOM1_ENST00000380561.2_Missense_Mutation_p.E306K|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Missense_Mutation_p.E337K|GCOM1_ENST00000572390.1_Missense_Mutation_p.E337K|MYZAP_ENST00000267853.5_Missense_Mutation_p.E337K|GCOM1_ENST00000587652.1_Missense_Mutation_p.E337K|MYZAP_ENST00000380565.4_Missense_Mutation_p.E337K|GCOM1_ENST00000380568.3_Missense_Mutation_p.E337K	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		337					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						TTCTGACAAGGAAAGGTAAGA	0.383000													8	21					0	0	1	0	0
MOS	4342	broad.mit.edu	37	8	57025542	57025542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57025542G>A	ENST00000311923.1	-	1	999	c.1000C>T	c.(1000-1002)Ctt>Ttt	p.L334F		NM_005372.1	NP_005363.1	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene homolog	334	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(12)|ovary(1)|urinary_tract(2)	22			Epithelial(17;0.00117)|all cancers(17;0.00879)			TCCACCAAAAGCAGCCGCGCG	0.567000													8	32					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65789247	65789247	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65789247C>T	ENST00000312106.5	-	3	1670	c.1533G>A	c.(1531-1533)tgG>tgA	p.W511*		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	511					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CCAAATTGTTCCAGAAGTCAA	0.592000													14	82					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179665278	179665278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179665278C>T	ENST00000589042.1	-	4	651	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	TTN_ENST00000342992.6_Missense_Mutation_p.E143K|TTN_ENST00000360870.5_Missense_Mutation_p.E143K|TTN_ENST00000460472.2_Missense_Mutation_p.E143K|TTN_ENST00000342175.6_Missense_Mutation_p.E143K|TTN_ENST00000359218.5_Missense_Mutation_p.E143K|TTN_ENST00000591111.1_Missense_Mutation_p.E143K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	143	Ig-like 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTGGATTTCGGCTCCATCC	0.502000													44	109					0	0	1	0	0
MITF	4286	broad.mit.edu	37	3	70014033	70014033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:70014033C>T	ENST00000352241.4	+	10	1360	c.1197C>T	c.(1195-1197)tcC>tcT	p.S399S	MITF_ENST00000394355.2_Silent_p.S374S|MITF_ENST00000314557.6_Silent_p.S292S|MITF_ENST00000328528.6_Silent_p.S398S|MITF_ENST00000314589.5_Silent_p.S383S|MITF_ENST00000531774.1_Silent_p.S236S|MITF_ENST00000472437.1_Silent_p.S347S|MITF_ENST00000448226.2_Silent_p.S405S|MITF_ENST00000394351.3_Silent_p.S298S	NM_198159.2	NP_937802.1	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	405					melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(6)|stomach(1)|urinary_tract(2)	30		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		ATGGACTTTCCCTTATTCCAT	0.453000			A		melanoma		"""Waardenburg syndrome type 2, Tietz syndrome"""						38	96					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9560897	9560897	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9560897C>T	ENST00000378429.3	-	5	1431	c.885G>A	c.(883-885)ccG>ccA	p.P295P	PAK7_ENST00000378423.1_Silent_p.P295P|PAK7_ENST00000353224.5_Silent_p.P295P	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	295	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			ATGGCATCATCGGTTCCTGGA	0.542000													52	139					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50266481	50266481	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50266481C>T	ENST00000246801.3	-	1	106	c.24G>A	c.(22-24)acG>acA	p.T8T		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	8							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		ACTGCCAGATCGTCTTCACCA	0.647000													52	92					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896749	175896749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175896749C>T	ENST00000359240.3	+	5	743	c.73C>T	c.(73-75)Ccc>Tcc	p.P25S	ADAM29_ENST00000404450.4_Missense_Mutation_p.P25S|ADAM29_ENST00000445694.1_Missense_Mutation_p.P25S|ADAM29_ENST00000514159.1_Missense_Mutation_p.P25S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	25					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GGATGAGCACCCCCAATATCA	0.512000													19	58					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106526727	106526727	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:106526727A>G	ENST00000359195.3	+	10	3330	c.3020A>G	c.(3019-3021)cAg>cGg	p.Q1007R	PIK3CG_ENST00000496166.1_Missense_Mutation_p.Q1007R|PIK3CG_ENST00000440650.2_Missense_Mutation_p.Q1007R	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1007	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						CCACACTTCCAGAAATTTCAG	0.493000													24	48					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6238577	6238577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6238577G>A	ENST00000524416.1	-	9	2549	c.2239C>T	c.(2239-2241)Ccc>Tcc	p.P747S	FAM160A2_ENST00000265978.4_Intron|FAM160A2_ENST00000449352.2_Intron			Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	743					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACACAGAAGGGAAGGCCTAGG	0.552000													19	27					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11154776	11154776	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11154776C>T	ENST00000409790.1	+	19	2243	c.2013C>T	c.(2011-2013)ttC>ttT	p.F671F	CLEC16A_ENST00000409552.3_Silent_p.F653F|CLEC16A_ENST00000465491.1_3'UTR	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	671								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GGGTGTTCTTCATGCTGCGTT	0.542000													64	234					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20665659	20665659	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20665659C>T	ENST00000357366.3	+	1	165	c.165C>T	c.(163-165)ttC>ttT	p.F55F		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TCCTGGGCTTCCCTTGCCCCA	0.512000													19	55					0	0	1	0	0
UBE2Q2	92912	broad.mit.edu	37	15	76175737	76175737	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:76175737C>T	ENST00000267938.4	+	9	1238	c.856C>T	c.(856-858)Cga>Tga	p.R286*	UBE2Q2_ENST00000338677.4_Nonsense_Mutation_p.R286*|UBE2Q2_ENST00000569423.1_Nonsense_Mutation_p.R251*|UBE2Q2_ENST00000561851.1_Nonsense_Mutation_p.R270*	NM_173469.2	NP_775740.1	Q8WVN8	UB2Q2_HUMAN	ubiquitin-conjugating enzyme E2Q family member 2	286					protein K48-linked ubiquitination	cytoplasm	ATP binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	12						TCCATTTGTTCGAGTGGTGTT	0.284000													28	81					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109103252	109103252	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:109103252C>T	ENST00000261483.4	+	6	1904	c.852C>T	c.(850-852)tcC>tcT	p.S284S		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	284					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding	p.S284S(1)		breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		AACCTCGGTCCGGCTGGGCTA	0.388000													51	92					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140409953	140409953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140409953C>T	ENST00000286349.3	+	4	2195	c.2004C>T	c.(2002-2004)aaC>aaT	p.N668N		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	668	Fibronectin type-III.					intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AGCTGCACAACCTGACCCCCA	0.428000													45	109					0	0	1	0	0
USPL1	10208	broad.mit.edu	37	13	31232685	31232685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:31232685C>T	ENST00000255304.4	+	9	2813	c.2471C>T	c.(2470-2472)cCc>cTc	p.P824L		NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	824					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AAGCCTCCTCCCATCAGTAAG	0.483000													30	79					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566459	5566459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5566459C>T	ENST00000322653.4	-	1	320	c.295G>A	c.(295-297)Gaa>Aaa	p.E99K	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E99K(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AATGTGATTTCGCGAGCCCCT	0.468000													30	43					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34087766	34087766	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34087766C>T	ENST00000373381.4	-	37	6004		c.e37+1		CSMD2_ENST00000373377.1_Splice_Site|CSMD2_ENST00000373388.2_Splice_Site|CSMD2_ENST00000373380.1_Splice_Site	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGATTCTCACTTTTGTACTC	0.507000													76	153					0	0	1	0	0
HHAT	55733	broad.mit.edu	37	1	210577852	210577852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210577852C>T	ENST00000367010.1	+	6	740	c.513C>T	c.(511-513)ttC>ttT	p.F171F	HHAT_ENST00000545781.1_Silent_p.F108F|HHAT_ENST00000261458.3_Silent_p.F171F|HHAT_ENST00000545154.1_Silent_p.F172F|HHAT_ENST00000413764.2_Silent_p.F171F|HHAT_ENST00000391905.3_Silent_p.F171F|HHAT_ENST00000537898.1_Silent_p.F106F|HHAT_ENST00000541565.1_Intron|HHAT_ENST00000308852.6_Silent_p.F126F	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	171					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		TGCTGCAGTTCACGCTGACCG	0.542000													28	46					0	0	1	0	0
TAGAP	117289	broad.mit.edu	37	6	159462467	159462467	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159462467C>T	ENST00000367066.3	-	6	727	c.396G>A	c.(394-396)aaG>aaA	p.K132K	TAGAP_ENST00000326965.6_5'UTR|RP1-111C20.4_ENST00000607391.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000606466.1_RNA|TAGAP_ENST00000338313.5_Silent_p.K132K	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	132	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CCTTCAGCTCCTTACGGGCTT	0.522000													24	48					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93104242	93104242	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93104242A>T	ENST00000298050.3	+	7	685	c.585A>T	c.(583-585)aaA>aaT	p.K195N		NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	195										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TAAATGGTAAAAAACAGTGCT	0.328000													15	21					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41040073	41040073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41040073G>A	ENST00000352632.3	+	20	4268	c.4182G>A	c.(4180-4182)gaG>gaA	p.E1394E	SPTBN4_ENST00000392023.1_Silent_p.E70E|SPTBN4_ENST00000392025.1_Silent_p.E137E|SPTBN4_ENST00000595535.1_Silent_p.E1394E|SPTBN4_ENST00000598249.1_Silent_p.E1394E|SPTBN4_ENST00000338932.3_Silent_p.E1394E			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1394					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCTGGGCGGAGCTGGAGAGCA	0.642000													11	18					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1943503	1943503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1943503C>T	ENST00000543818.1	+	5	1571	c.729C>T	c.(727-729)ccC>ccT	p.P243P	LRTM2_ENST00000543730.1_3'UTR|LRTM2_ENST00000535041.1_Silent_p.P243P|LRTM2_ENST00000299194.1_Silent_p.P243P|CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000382722.5_Intron|CACNA2D4_ENST00000585732.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	243	LRRCT.					integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GGATGGTCCCCATGGAGATGT	0.597000													13	43					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15299893	15299893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15299893C>T	ENST00000263388.2	-	8	1360	c.1285G>A	c.(1285-1287)Gag>Aag	p.E429K		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	429	EGF-like 10; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			ACATCGGTCTCACAGCGAGGT	0.642000													25	59					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538257	55538257	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55538257C>T	ENST00000220676.1	+	4	1963	c.1815C>T	c.(1813-1815)ttC>ttT	p.F605F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	605					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATGATAGGTTCAGTCCTATTT	0.378000													33	109					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3827613	3827613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3827613C>T	ENST00000262961.4	-	6	901	c.891G>A	c.(889-891)aaG>aaA	p.K297K		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	297						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CCGCCTCCTTCTTTCTGTGCT	0.692000													3	5					0	0	1	0	0
OR51B2	79345	broad.mit.edu	37	11	5344952	5344952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5344952G>A	ENST00000328813.2	-	1	630	c.576C>T	c.(574-576)ttC>ttT	p.F192F	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F192L(1)		NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGTCTATTGAAAGTTATGT	0.363000													20	46					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10108085	10108085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10108085G>A	ENST00000264828.3	-	11	1310	c.1225C>T	c.(1225-1227)Ccc>Tcc	p.P409S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	409	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GGGGGGCCGGGAGGGCCTGAG	0.602000													9	7					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612645	179612645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179612645G>A	ENST00000360870.5	-	46	14704	c.14482C>T	c.(14482-14484)Ctg>Ttg	p.L4828L	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	938	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGACTCAGGGAGAGCTGT	0.448000													21	51					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110836623	110836623	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110836623G>A	ENST00000502322.1	-	5	688	c.474C>T	c.(472-474)tcC>tcT	p.S158S	STARD4_ENST00000509887.1_3'UTR|STARD4_ENST00000511569.1_5'UTR|STARD4_ENST00000512160.1_Intron|STARD4_ENST00000296632.3_Intron			Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	0	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		TATCTCACAAGGAAAGAGACA	0.308000													16	42					0	0	1	0	0
IGLV2-8	28817	broad.mit.edu	37	22	23165508	23165508	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23165508C>T	ENST00000390317.2	+	0	241																											GACTCAGCCTCCCTCCGCGTC	0.592000													113	286					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169690824	169690824	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169690824G>T	ENST00000444448.2	+	9	969	c.493G>T	c.(493-495)Gag>Tag	p.E165*	NOSTRIN_ENST00000421711.2_Nonsense_Mutation_p.E137*|NOSTRIN_ENST00000397206.2_Nonsense_Mutation_p.E87*|NOSTRIN_ENST00000458381.2_Nonsense_Mutation_p.E165*|NOSTRIN_ENST00000317647.7_Nonsense_Mutation_p.E165*|NOSTRIN_ENST00000445023.2_Nonsense_Mutation_p.E87*|NOSTRIN_ENST00000397209.2_Nonsense_Mutation_p.E137*			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	165					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						GACTGAGAAGGAGAAGCGGAA	0.458000													14	56					0.000219431	0.000219748	1	1	0
NOTCH2	4853	broad.mit.edu	37	1	120458025	120458025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120458025G>A	ENST00000256646.2	-	34	7539	c.7320C>T	c.(7318-7320)acC>acT	p.T2440T		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	2440					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAGGGCTGGTGGTCACATCTG	0.582000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				22	110					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33292591	33292591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:33292591G>A	ENST00000280979.4	+	13	5742	c.5572G>A	c.(5572-5574)Gaa>Aaa	p.E1858K	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1858					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ACGTGTCTCTGAAAATAATGG	0.353000													36	68					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113146034	113146034	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113146034G>A	ENST00000316851.7	+	18	2472	c.2472G>A	c.(2470-2472)acG>acA	p.T824T	NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	834					axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AGACAGAAACGAAGCCAGCGC	0.547000													11	26					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30740710	30740710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30740710C>T	ENST00000262518.4	+	27	6329	c.5944C>T	c.(5944-5946)Cct>Tct	p.P1982S	SRCAP_ENST00000395059.2_Missense_Mutation_p.P1920S|SRCAP_ENST00000344771.4_Missense_Mutation_p.P1824S	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1982					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TGTCATGCCTCCTGTGGAGGC	0.567000													14	32					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124528805	124528805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:124528805C>T	ENST00000408936.3	+	9	1675	c.1493C>T	c.(1492-1494)gCc>gTc	p.A498V	DAB2IP_ENST00000309989.1_Missense_Mutation_p.A374V|DAB2IP_ENST00000259371.2_Missense_Mutation_p.A470V			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	498	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GAGGTGTTTGCCTCGTGGAGG	0.627000													16	32					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76965231	76965231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:76965231G>A	ENST00000261532.7	+	8	1531	c.1459G>A	c.(1459-1461)Gag>Aag	p.E487K	RP11-187O7.3_ENST00000554926.1_lincRNA|ESRRB_ENST00000380887.2_Intron|ESRRB_ENST00000509242.1_Intron			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	0						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		ATACCACCTGGAGGTTTTCCT	0.602000													10	24					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5247821	5247821	+	Missense_Mutation	SNP	G	G	A	rs63750556		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5247821G>A	ENST00000335295.3	-	2	476	c.301C>T	c.(301-303)Cct>Tct	p.P101S		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	101			P -> L (in Brigham; O(2) affinity up).|P -> R (in New Mexico).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	AAGTTCTCAGGATCCACGTGC	0.502000									Sickle Cell Trait				23	78					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189706735	189706735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189706735G>A	ENST00000319332.5	-	4	1113	c.916C>T	c.(916-918)Cct>Tct	p.P306S	LEPREL1_ENST00000427335.2_Missense_Mutation_p.P125S	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	306					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TAGTGCAGAGGAAGAAAATTC	0.493000													44	92					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111957747	111957747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111957747G>A	ENST00000369732.3	-	11	1431	c.1376C>T	c.(1375-1377)tCc>tTc	p.S459F		NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	459					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CTTTCCAAGGGATACAGTTTC	0.502000													28	74					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325048	57325048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57325048C>T	ENST00000326441.9	-	10	5125	c.4762G>A	c.(4762-4764)Ggc>Agc	p.G1588S	PEG3_ENST00000423103.2_Missense_Mutation_p.G1588S|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.G1462S|PEG3_ENST00000598410.1_Missense_Mutation_p.G1464S|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1588					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGCCCTCAGCCAGTGTGGGTA	0.493000													10	41					0	0	1	0	0
ABCD1	215	broad.mit.edu	37	X	152991603	152991603	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:152991603C>T	ENST00000218104.3	+	1	1281	c.882C>T	c.(880-882)gcC>gcT	p.A294A	ABCD1_ENST00000370129.4_Silent_p.A109A	NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	294	ABC transmembrane type-1.		A -> T (in X-ALD; AMN-type).		fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGATCGCCTTCTATGGGG	0.706000													2	1					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56392835	56392835	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56392835G>A	ENST00000301295.6	+	10	3289		c.e10-1		NLRP4_ENST00000346986.5_Splice_Site|NLRP4_ENST00000587891.1_Splice_Site	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4								ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TATTTTACCAGGCTGAGAAAA	0.413000													7	24					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80722519	80722519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80722519G>A	ENST00000458043.2	+	35	4253	c.4247G>A	c.(4246-4248)cGa>cAa	p.R1416Q	OTOGL_ENST00000547103.1_Missense_Mutation_p.R1416Q	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GTTTATCCACGAGACTGTAAG	0.378000													13	25					0	0	1	0	0
BIRC8	112401	broad.mit.edu	37	19	53792933	53792933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53792933C>T	ENST00000426466.1	-	1	1942	c.695G>A	c.(694-696)aGa>aAa	p.R232K		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	232					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		CATAAAAACTCTTTGCTTGAA	0.388000													15	160					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13901376	13901376	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13901376C>T	ENST00000265104.4	-	14	2141	c.2037G>A	c.(2035-2037)agG>agA	p.R679R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	679	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GAAGCCACGCCCTGTGGAAGA	0.478000									Kartagener syndrome				16	43					0	0	1	0	0
POLH	5429	broad.mit.edu	37	6	43550847	43550847	+	Missense_Mutation	SNP	C	C	T	rs113074920		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43550847C>T	ENST00000372236.4	+	3	536	c.241C>T	c.(241-243)Cgt>Tgt	p.R81C	POLH_ENST00000372226.1_Missense_Mutation_p.R81C|POLH_ENST00000535400.1_Missense_Mutation_p.R19C	NM_006502.2	NP_006493.1	Q9Y253	POLH_HUMAN	polymerase (DNA directed), eta	81	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			GGCACAAGTTCGTGAGTCCCG	0.413000								DNA polymerases (catalytic subunits)	Xeroderma Pigmentosum				17	46					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37707446	37707446	+	Silent	SNP	G	G	A	rs112589819		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37707446G>A	ENST00000539465.1	+	3	728	c.135G>A	c.(133-135)agG>agA	p.R45R	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Silent_p.R45R			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	45						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GGCCCGCCAGGAACCCAACTC	0.498000													28	70					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888670	38888670	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38888670C>T	ENST00000302328.3	-	26	5089	c.4891G>A	c.(4891-4893)Gaa>Aaa	p.E1631K	SCN11A_ENST00000456224.3_Missense_Mutation_p.E1593K|SCN11A_ENST00000450244.1_Missense_Mutation_p.E1631K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1631					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.E1631K(1)		NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCAAACTTTTCCCACACTTCA	0.408000													42	139					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1258188	1258188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1258188G>A	ENST00000447027.1	+	25	3158	c.3100G>A	c.(3100-3102)Gac>Aac	p.D1034N	MUC5B_ENST00000529681.1_Missense_Mutation_p.D1031N			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1031	VWFD 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GAACTTCGACGACAATGCCAT	0.672000													3	7					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113243788	113243788	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113243788C>T	ENST00000297405.5	-	69	11058	c.10814G>A	c.(10813-10815)gGc>gAc	p.G3605D	CSMD3_ENST00000352409.3_Missense_Mutation_p.G3535D|CSMD3_ENST00000343508.3_Missense_Mutation_p.G3565D|CSMD3_ENST00000455883.2_Missense_Mutation_p.G3436D	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3605						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCTTTGTAGGCCAAATTGTCC	0.328000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			28	130					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102585936	102585936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:102585936C>T	ENST00000251808.3	+	6	1113	c.775C>T	c.(775-777)Cgt>Tgt	p.R259C	GRHL2_ENST00000395927.1_Missense_Mutation_p.R243C	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	259						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			CAAATCTCTCCGTCAGAAGCA	0.507000													15	43					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5203915	5203915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5203915C>T	ENST00000334314.3	-	3	358	c.282G>A	c.(280-282)cgG>cgA	p.R94R						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						CCAATTCTGCCCGAAAGAAAG	0.393000													10	26					0	0	1	0	0
NT5DC2	64943	broad.mit.edu	37	3	52563345	52563345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52563345G>A	ENST00000307076.4	-	2	527	c.127C>T	c.(127-129)Ctg>Ttg	p.L43L	NT5DC2_ENST00000422318.2_Silent_p.L80L|NT5DC2_ENST00000307092.4_Silent_p.L9L|NT5DC2_ENST00000459839.1_Silent_p.L80L|NT5DC2_ENST00000490681.1_5'UTR	NM_022908.2	NP_075059.1	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2	43							hydrolase activity|metal ion binding			endometrium(1)|lung(3)|prostate(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		TCGGGGGGCAGGAGGTCTAGA	0.587000													7	37					0	0	1	0	0
ME3	10873	broad.mit.edu	37	11	86382822	86382822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:86382822C>T	ENST00000543262.1	-	2	491	c.165G>A	c.(163-165)agG>agA	p.R55R	ME3_ENST00000393324.3_Silent_p.R55R|ME3_ENST00000359636.2_Silent_p.R55R	NM_001161586.1	NP_001155058.1	Q16798	MAON_HUMAN	malic enzyme 3, NADP(+)-dependent, mitochondrial	55					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|skin(3)|stomach(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	GATGAGGGTTCCTGGTGACAT	0.682000													23	50					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14868871	14868871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14868871C>T	ENST00000380881.4	-	3	920	c.105G>A	c.(103-105)atG>atA	p.M35I	FREM1_ENST00000422223.2_Missense_Mutation_p.M35I|FREM1_ENST00000380880.3_Missense_Mutation_p.M35I			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	35					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGTGGCCCTTCATCACCCTCA	0.562000													7	11					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981484	70981484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70981484G>A	ENST00000276594.2	-	2	813	c.612C>T	c.(610-612)ttC>ttT	p.F204F		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CGTACAGAACGAAGTGCAGGT	0.602000													27	64					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12409257	12409257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12409257C>T	ENST00000358136.3	+	46	9387	c.9257C>T	c.(9256-9258)tCg>tTg	p.S3086L	VPS13D_ENST00000356315.4_Missense_Mutation_p.S3061L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3085					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCAGGGGATTCGTTTGCTGTG	0.502000													43	160					0	0	1	0	0
PAXIP1	22976	broad.mit.edu	37	7	154738116	154738116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:154738116G>A	ENST00000404141.1	-	20	3307	c.3153C>T	c.(3151-3153)ttC>ttT	p.F1051F	PAXIP1_ENST00000397192.1_Silent_p.F1051F|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	1051	BRCT 6.|Interaction with TP53BP1.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		CAGTCAGAACGAACTCTGCAT	0.433000													68	131					0	0	1	0	0
CCDC83	220047	broad.mit.edu	37	11	85606413	85606413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:85606413G>A	ENST00000280245.4	+	6	1101	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	CCDC83_ENST00000376067.1_Missense_Mutation_p.E98K|CCDC83_ENST00000342404.3_Missense_Mutation_p.E197K|CCDC83_ENST00000529676.2_3'UTR	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	197										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CCAAAAGAAGGAATGGGCCAC	0.284000													25	65					0	0	1	0	0
PRPSAP1	5635	broad.mit.edu	37	17	74326663	74326663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74326663G>A	ENST00000446526.3	-	5	993	c.548C>T	c.(547-549)tCa>tTa	p.S183L	PRPSAP1_ENST00000324684.4_Missense_Mutation_p.S80L	NM_002766.2	NP_002757.2	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 1	154					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17						CAGGAAAGGTGAGGCTCTAAG	0.388000													25	60					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16955967	16955967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:16955967G>A	ENST00000377833.4	-	48	7441	c.7376C>T	c.(7375-7377)tCt>tTt	p.S2459F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2459	CUB 18.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGTTCCAATAGAGCCCTGAAG	0.478000													29	75					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73152144	73152144	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:73152144C>T	ENST00000377110.2	-	25	4092	c.3849G>A	c.(3847-3849)tcG>tcA	p.S1283S	TRPM3_ENST00000396280.5_Silent_p.S1132S|TRPM3_ENST00000357533.2_Silent_p.S1287S|TRPM3_ENST00000377111.2_Silent_p.S1283S|TRPM3_ENST00000408909.2_Silent_p.S1142S|TRPM3_ENST00000360823.2_Silent_p.S1145S|TRPM3_ENST00000377106.1_Silent_p.S1155S|TRPM3_ENST00000396285.1_Silent_p.S1142S|TRPM3_ENST00000423814.3_Silent_p.S1310S|TRPM3_ENST00000358082.3_Silent_p.S1145S|TRPM3_ENST00000377105.1_Silent_p.S1142S|TRPM3_ENST00000396292.4_Silent_p.S1155S	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1308						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						ACGAGGTCCTCGAGCGGATTT	0.612000													33	64					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39879654	39879654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39879654C>T	ENST00000260356.5	+	8	1392	c.1227C>T	c.(1225-1227)ctC>ctT	p.L409L		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	409	TSP type-1 1.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GCGATAGCCTCAACAACCGAT	0.577000													8	32					0	0	1	0	0
ITFG3	83986	broad.mit.edu	37	16	314141	314141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:314141C>T	ENST00000399932.3	+	11	1766	c.1315C>T	c.(1315-1317)Ctc>Ttc	p.L439F	ITFG3_ENST00000442458.2_Missense_Mutation_p.L439F|ITFG3_ENST00000301679.2_Missense_Mutation_p.L439F|ITFG3_ENST00000450082.2_Missense_Mutation_p.L439F|ITFG3_ENST00000301678.3_Missense_Mutation_p.L439F|ITFG3_ENST00000600536.1_Missense_Mutation_p.L439F			Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	439						integral to membrane				central_nervous_system(3)|endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				CTTCTGGGGCCTCCACGAGCT	0.701000													4	19					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64222206	64222206	+	Missense_Mutation	SNP	C	C	T	rs138448367	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64222206C>T	ENST00000205948.6	-	3	315	c.278G>A	c.(277-279)gGa>gAa	p.G93E		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	93	Sushi 2.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			GCGTACGGCTCCATTTTCTAA	0.358000													17	58					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25043497	25043497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:25043497C>T	ENST00000216336.2	-	4	584	c.548G>A	c.(547-549)aGg>aAg	p.R183K		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	183	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		ACAAATCTGCCTTCGGGGGTC	0.622000													16	31					0	0	1	0	0
MARCH11	441061	broad.mit.edu	37	5	16067687	16067687	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:16067687G>A	ENST00000332432.8	-	4	1301	c.1102C>T	c.(1102-1104)Cag>Tag	p.Q368*		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	368						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						TAGCCACACTGAAACCTTGGT	0.498000													47	130					0	0	1	0	0
ZNF133	7692	broad.mit.edu	37	20	18295752	18295752	+	Missense_Mutation	SNP	C	C	T	rs140722849		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:18295752C>T	ENST00000377671.3	+	7	813	c.254C>T	c.(253-255)cCt>cTt	p.P85L	ZNF133_ENST00000462170.1_3'UTR|RP4-568F9.3_ENST00000436848.1_RNA|ZNF133_ENST00000402618.2_Missense_Mutation_p.P23L|ZNF133_ENST00000538547.1_5'UTR|ZNF133_ENST00000316358.4_Missense_Mutation_p.P86L|ZNF133_ENST00000401790.1_Missense_Mutation_p.P86L|ZNF133_ENST00000535822.1_5'UTR|ZNF133_ENST00000396026.3_Missense_Mutation_p.P89L	NM_001083330.1|NM_003434.4	NP_001076799.1|NP_003425.2	P52736	ZN133_HUMAN	zinc finger protein 133	86						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						CCTTTCTGCCCTCCGGGTTTC	0.527000													28	115					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94711930	94711930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94711930G>A	ENST00000304338.3	+	13	1505	c.1351G>A	c.(1351-1353)Gat>Aat	p.D451N		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	451						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AAAGGTACTAGATGCTCTTAT	0.308000													23	66					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201356012	201356012	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201356012C>T	ENST00000391967.2	-	3	778	c.477G>A	c.(475-477)gaG>gaA	p.E159E	LAD1_ENST00000367313.3_Silent_p.E173E	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	159						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						CCACCAAGCTCTCCTCCTCCA	0.587000													21	116					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544596	82544596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82544596G>A	ENST00000423517.2	-	7	13043	c.12706C>T	c.(12706-12708)Ctc>Ttc	p.L4236F	PCLO_ENST00000333891.8_Missense_Mutation_p.L4236F|PCLO_ENST00000437081.1_Missense_Mutation_p.L956F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4167	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTTGAAGGAGCCTTGCCCTG	0.398000													13	41					0	0	1	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50461685	50461685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50461685G>A	ENST00000447370.2	-	8	1596	c.1506C>T	c.(1504-1506)tcC>tcT	p.S502S	SIGLEC11_ENST00000426971.2_Intron	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	502					cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		TGACCTCGAAGGAGCCCTGAC	0.697000													4	18					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40710658	40710658	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40710658C>T	ENST00000373198.3	-	31	4438		c.e31-1		PTPRT_ENST00000373193.3_Splice_Site|PTPRT_ENST00000373184.1_Splice_Site|PTPRT_ENST00000373201.1_Splice_Site|PTPRT_ENST00000373190.1_Splice_Site|PTPRT_ENST00000373187.1_Splice_Site|PTPRT_ENST00000356100.2_Splice_Site	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T						homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCCCCCATTTCTAAACACAGA	0.498000													20	75					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167051693	167051693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167051693C>T	ENST00000392766.2	-	10	949	c.609G>A	c.(607-609)gaG>gaA	p.E203E	ZBBX_ENST00000307529.5_Silent_p.E203E|ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Silent_p.E174E|ZBBX_ENST00000392767.2_Silent_p.E203E|ZBBX_ENST00000455345.2_Silent_p.E203E	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	203						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AATTATTCTCCTCTTTGGGTT	0.328000													19	57					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140616020	140616020	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140616020G>A	ENST00000526308.1	+	0	2083					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						GCTGCTGAGCGAGCGCGACGC	0.711000													35	89					0	0	1	0	0
WDR13	64743	broad.mit.edu	37	X	48458948	48458948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48458948C>T	ENST00000218056.5	+	5	1270	c.765C>T	c.(763-765)atC>atT	p.I255I		NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	255						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						TCCGAGAGATCCCTGACCCCG	0.597000													10	8					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37153991	37153991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:37153991G>A	ENST00000274258.7	-	41	8343	c.4756C>T	c.(4756-4758)Cct>Tct	p.P1586S	C5orf42_ENST00000425232.2_Missense_Mutation_p.P2688S|C5orf42_ENST00000508244.1_Missense_Mutation_p.P2688S			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2688										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CTTGGTGCAGGGCAAGCTGCA	0.468000													17	79					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149901663	149901663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149901663G>A	ENST00000439741.2	-	16	2043	c.1793C>T	c.(1792-1794)tCc>tTc	p.S598F	MTMR11_ENST00000406732.3_3'UTR|MTMR11_ENST00000492824.1_5'UTR|MTMR11_ENST00000361405.6_3'UTR|MTMR11_ENST00000369140.3_Missense_Mutation_p.S526F	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	598	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GCTTTCAGAGGAGATAGCAGG	0.602000													25	74					0	0	1	0	0
IL26	55801	broad.mit.edu	37	12	68619438	68619438	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:68619438G>T	ENST00000229134.4	-	1	163	c.99C>A	c.(97-99)taC>taA	p.Y33*	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	33					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTCCCCTTGGGTAACAACTTT	0.433000													23	222					5.45024e-15	5.47918e-15	1	1	0
GRXCR2	643226	broad.mit.edu	37	5	145246165	145246165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145246165C>T	ENST00000377976.1	-	2	462	c.463G>A	c.(463-465)Gag>Aag	p.E155K		NM_001080516.1	NP_001073985.1	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	155										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|urinary_tract(2)	7						ATCAGAGACTCTTCCTCAGCC	0.443000													52	122					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43414954	43414954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43414954C>T	ENST00000187910.2	-	3	549	c.484G>A	c.(484-486)Gag>Aag	p.E162K	PSG6_ENST00000292125.2_Missense_Mutation_p.E162K|PSG6_ENST00000402603.4_Missense_Mutation_p.E162K	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				CGCACAGCCTCCATGACCTCC	0.542000													58	256					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17446091	17446091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:17446091C>T	ENST00000262545.2	+	11	1638	c.1323C>T	c.(1321-1323)ctC>ctT	p.L441L	PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000536609.1_Silent_p.L406L|PCSK2_ENST00000377899.1_Silent_p.L422L	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	441					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTAATCACCTCTTTGGCTACG	0.557000													16	40					0	0	1	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31692252	31692252	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31692252C>T	ENST00000360542.3	-	1	355	c.102G>A	c.(100-102)gtG>gtA	p.V34V		NM_203405.1	NP_981950.1	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	34						intermediate filament				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16						CTCCACAGCTCACGCTGGTAG	0.557000													38	91					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70917960	70917960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70917960G>A	ENST00000264436.3	-	8	1251	c.807C>T	c.(805-807)gcC>gcT	p.A269A	ADD2_ENST00000407644.2_Silent_p.A269A|ADD2_ENST00000430656.1_Silent_p.A285A|ADD2_ENST00000355733.3_Silent_p.A269A|AC007395.3_ENST00000457851.1_RNA|ADD2_ENST00000413157.2_Silent_p.A269A	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	269					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						TGATCCGATCGGCTTCCTGCT	0.532000													24	81					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42490089	42490089	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42490089C>T	ENST00000545399.1	-	6	725	c.572G>A	c.(571-573)gGg>gAg	p.G191E	ATP1A3_ENST00000602133.1_Missense_Mutation_p.G148E|ATP1A3_ENST00000543770.1_Missense_Mutation_p.G189E|ATP1A3_ENST00000302102.5_Missense_Mutation_p.G178E	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	178					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CACCAGGTCCCCGACCACCAC	0.627000													42	128					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184099561	184099561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184099561C>T	ENST00000204604.1	+	5	815	c.569C>T	c.(568-570)tCg>tTg	p.S190L	CHRD_ENST00000348986.3_Missense_Mutation_p.S190L|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000450923.1_Missense_Mutation_p.S190L|CHRD_ENST00000482805.1_3'UTR	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	190	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCCGAGTCTCGCTGCTGCGC	0.662000													13	17					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466553	56466553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56466553G>A	ENST00000291971.3	+	3	1200	c.1129G>A	c.(1129-1131)Gac>Aac	p.D377N	NLRP8_ENST00000590542.1_Missense_Mutation_p.D377N	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	377	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		AGAGGAGGGAGACCAAGTCTT	0.478000													27	103					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14775943	14775943	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14775943G>A	ENST00000380881.4	-	26	5519	c.4704C>T	c.(4702-4704)ttC>ttT	p.F1568F	FREM1_ENST00000380894.1_Silent_p.F103F|FREM1_ENST00000422223.2_Silent_p.F1567F|FREM1_ENST00000380880.3_Silent_p.F1567F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1567					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCTGCTGGGTGAAATTGTGTT	0.557000													13	122					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55614818	55614818	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55614818G>A	ENST00000326258.1	+	1	10	c.10G>A	c.(10-12)Gaa>Aaa	p.E4K		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						TATGATCTGTGAAAATCACAC	0.313000													28	168					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159505396	159505396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159505396G>A	ENST00000334857.2	-	1	446	c.402C>T	c.(400-402)gtC>gtT	p.V134V		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					TGCTCATGATGACAGTGTATC	0.483000													38	83					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120598020	120598020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120598020G>A	ENST00000300648.6	-	23	2488	c.2476C>T	c.(2476-2478)Ctg>Ttg	p.L826L		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	826					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTGCTGGTCAGCTGCACCTCC	0.582000													25	81					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468546	56468546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56468546C>T	ENST00000312153.1	+	1	683	c.683C>T	c.(682-684)tCc>tTc	p.S228F		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						TTGAGGATCTCCTCCTCCAAG	0.512000													42	214					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60708742	60708742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60708742G>A	ENST00000227880.3	-	5	1361	c.1128C>T	c.(1126-1128)ctC>ctT	p.L376L		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	376					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						CATTGGCCAGGAGGAGCCAGG	0.597000													11	26					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9264799	9264799	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9264799G>A	ENST00000318602.7	-	4	746	c.439C>T	c.(439-441)Cgt>Tgt	p.R147C		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	147					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GAGACAACACGAAATTTCACT	0.393000													10	49					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72290353	72290353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72290353G>A	ENST00000334456.5	-	27	2576	c.2331C>T	c.(2329-2331)ttC>ttT	p.F777F	PDE2A_ENST00000544570.1_Silent_p.F770F|PDE2A_ENST00000418754.2_Silent_p.F662F|PDE2A_ENST00000444035.2_Silent_p.F768F|PDE2A_ENST00000540345.1_Silent_p.F768F|PDE2A_ENST00000376450.3_Silent_p.F521F	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	777	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GGAGGTCCTTGAAGATGCGGA	0.602000													43	78					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656741	19656741	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19656741C>T	ENST00000586018.1	+	8	3507	c.3405C>T	c.(3403-3405)atC>atT	p.I1135I	CILP2_ENST00000291495.4_Silent_p.I1129I			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1129						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						TTGGTGACATCCGCAGGGAGA	0.731000													4	17					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50294041	50294041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50294041G>A	ENST00000332853.3	-	3	508	c.485C>T	c.(484-486)tCa>tTa	p.S162L		NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	162						integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						CTCAAAGGATGACTCTTCAGA	0.318000													12	61					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	705079	705079	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:705079C>T	ENST00000549091.1	+	14	1580	c.1488C>T	c.(1486-1488)gtC>gtT	p.V496V	LA16c-349E10.1_ENST00000573609.1_RNA|WDR90_ENST00000293879.4_Silent_p.V496V	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	496										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GCGAGGTGGTCGTTCTGGCAA	0.652000													13	70					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2786312	2786312	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2786312C>T	ENST00000399655.1	+	40	5146	c.4881C>T	c.(4879-4881)taC>taT	p.Y1627Y	CACNA1C_ENST00000399637.1_Silent_p.Y1646Y|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000335762.5_Silent_p.Y1652Y|CACNA1C_ENST00000399603.1_Silent_p.Y1627Y|CACNA1C_ENST00000399649.1_Silent_p.Y1633Y|CACNA1C_ENST00000399595.1_Silent_p.Y1635Y|CACNA1C_ENST00000399606.1_Silent_p.Y1647Y|CACNA1C_ENST00000399601.1_Silent_p.Y1627Y|CACNA1C_ENST00000399617.1_Silent_p.Y1627Y|CACNA1C_ENST00000344100.3_Silent_p.Y1668Y|CACNA1C_ENST00000399621.1_Silent_p.Y1646Y|CACNA1C_ENST00000399629.1_Silent_p.Y1644Y|CACNA1C_ENST00000327702.7_Silent_p.Y1627Y|CACNA1C_ENST00000406454.3_Silent_p.Y1627Y|CACNA1C_ENST00000402845.3_Silent_p.Y1646Y|CACNA1C_ENST00000399597.1_Silent_p.Y1627Y|CACNA1C_ENST00000347598.4_Silent_p.Y1675Y|CACNA1C_ENST00000399641.1_Silent_p.Y1627Y|CACNA1C_ENST00000399638.1_Silent_p.Y1655Y|CACNA1C_ENST00000399644.1_Silent_p.Y1627Y|CACNA1C_ENST00000399591.1_Silent_p.Y1635Y|CACNA1C_ENST00000399634.1_Silent_p.Y1627Y	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1675					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity	p.Y1675*(1)|p.Y1705*(1)|p.Y1162*(1)|p.Y1668*(1)|p.Y1627*(1)		NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCCAGGAGTACTTCCGGAAGT	0.607000													11	22					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34247714	34247714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:34247714G>A	ENST00000346562.2	+	8	1067	c.993G>A	c.(991-993)ggG>ggA	p.G331G	NPAS3_ENST00000551492.1_Silent_p.G368G|NPAS3_ENST00000357798.5_Silent_p.G350G|NPAS3_ENST00000548645.1_Silent_p.G333G|NPAS3_ENST00000356141.4_Silent_p.G363G	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	363	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		ATATCGTAGGGAAGAGATGCT	0.468000													30	67					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107979432	107979432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107979432G>A	ENST00000372129.2	-	1	219	c.143C>T	c.(142-144)tCg>tTg	p.S48L		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	48						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CGGACAAGACGACCCGGTCCC	0.657000													15	18					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569894	241569894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241569894C>T	ENST00000319838.5	+	6	1467	c.525C>T	c.(523-525)ttC>ttT	p.F175F	GPR35_ENST00000438013.2_Silent_p.F206F|GPR35_ENST00000407714.1_Silent_p.F175F|GPR35_ENST00000430267.1_Silent_p.F175F|GPR35_ENST00000403859.1_Silent_p.F175F	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	175						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		CCATGGCGTTCCCGCTGCTGG	0.657000													16	72					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545156	186545156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186545156G>A	ENST00000431808.1	-	14	1978	c.1415C>T	c.(1414-1416)tCc>tTc	p.S472F	SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.S376F|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.S572F|SORBS2_ENST00000284776.7_Missense_Mutation_p.S472F|SORBS2_ENST00000319471.9_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	472						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GGACTTCACGGAGCAGATCAC	0.607000													32	83					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74542148	74542148	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74542148C>T	ENST00000394019.2	-	6	400	c.3G>A	c.(1-3)atG>atA	p.M1I	SLC4A5_ENST00000346834.4_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000483195.1_Intron|SLC4A5_ENST00000377632.1_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000377634.4_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000359484.4_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000357822.5_Start_Codon_SNP_p.M1I|SLC4A5_ENST00000358683.4_Start_Codon_SNP_p.M1I|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Start_Codon_SNP_p.M1I	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CCTTCACCTTCATGACTATAA	0.428000													66	156					0	0	1	0	0
NSUN4	387338	broad.mit.edu	37	1	46810805	46810805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46810805C>T	ENST00000474844.1	+	2	1076	c.426C>T	c.(424-426)ttC>ttT	p.F142F	NSUN4_ENST00000537428.1_Silent_p.F93F|NSUN4_ENST00000536062.1_Silent_p.F93F|NSUN4_ENST00000498008.1_3'UTR	NM_199044.3	NP_950245.2	Q96CB9	NSUN4_HUMAN	NOP2/Sun domain family, member 4	142							methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	8	Acute lymphoblastic leukemia(166;0.155)					TCAGTCGCTTCCCTCCTGCCA	0.562000													23	48					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74004825	74004825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74004825C>T	ENST00000301607.3	-	22	4714	c.4461G>A	c.(4459-4461)caG>caA	p.Q1487Q	EVPL_ENST00000586740.1_Silent_p.Q1509Q	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1487	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GGGTCTTCTCCTGGTCCAGGT	0.572000													62	120					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72492920	72492920	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72492920G>A	ENST00000319622.6	-	10	1840	c.1384C>T	c.(1384-1386)Cag>Tag	p.Q462*	PKM_ENST00000565154.1_Nonsense_Mutation_p.Q462*|PKM_ENST00000449901.2_Nonsense_Mutation_p.Q447*|PKM_ENST00000389093.3_Nonsense_Mutation_p.Q462*|PKM_ENST00000565184.1_Nonsense_Mutation_p.Q462*|PKM_ENST00000568459.1_Nonsense_Mutation_p.Q462*|PKM_ENST00000568883.1_Nonsense_Mutation_p.Q297*|PKM_ENST00000335181.5_Nonsense_Mutation_p.Q462*	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						AGGTGGGCCTGACGAGCTGTC	0.617000													9	109					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29562632	29562632	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:29562632G>T	ENST00000358273.4	+	28	4095	c.3712G>T	c.(3712-3714)Gaa>Taa	p.E1238*	NF1_ENST00000356175.3_Nonsense_Mutation_p.E1238*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1238	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTCTCAGGATGAACTAGCTCG	0.378000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			84	131					4.02937e-33	4.05804e-33	1	1	0
GIMAP8	155038	broad.mit.edu	37	7	150163999	150163999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150163999C>T	ENST00000307271.3	+	2	787	c.213C>T	c.(211-213)tcC>tcT	p.S71S		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	71						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ACCTTTTCTCCTCAATAGCTT	0.502000													68	140					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92560267	92560267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:92560267C>T	ENST00000377067.3	+	6	1729	c.1357C>T	c.(1357-1359)Cct>Tct	p.P453S		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	453						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AGGAATTGATCCTGTGATAAA	0.353000													16	63					0	0	1	0	0
ZNF174	7727	broad.mit.edu	37	16	3454458	3454458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3454458C>T	ENST00000268655.4	+	2	1020	c.435C>T	c.(433-435)ctC>ctT	p.L145L	ZNF174_ENST00000571936.1_Silent_p.L145L|ZNF174_ENST00000344823.5_Silent_p.L145L|ZNF174_ENST00000575752.1_Silent_p.L145L|LA16c-306E5.2_ENST00000575785.1_RNA|ZNF174_ENST00000572544.1_Silent_p.L145L	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	145					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						AAAAGGTGCTCTTGGAGAAAA	0.512000													58	107					0	0	1	0	0
FAM181A	90050	broad.mit.edu	37	14	94395108	94395108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94395108C>T	ENST00000267594.5	+	3	970	c.663C>T	c.(661-663)ccC>ccT	p.P221P	FAM181A_ENST00000557719.1_Silent_p.P159P|FAM181A_ENST00000557000.2_Silent_p.P159P|FAM181A_ENST00000556222.1_Silent_p.P159P	NM_001207073.1|NM_001207074.1|NM_138344.4	NP_001194002.1|NP_001194003.1|NP_612353.3	Q8N9Y4	F181A_HUMAN	family with sequence similarity 181, member A	221										cervix(1)|endometrium(2)|large_intestine(8)|lung(4)|prostate(1)|skin(2)	18						GACTGGGCCCCAGGGAGGGAC	0.627000													15	35					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37319368	37319368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37319368C>T	ENST00000262825.5	+	3	376	c.159C>T	c.(157-159)gcC>gcT	p.A53A	CSF2RB_ENST00000406230.1_Silent_p.A53A|CSF2RB_ENST00000403662.3_Silent_p.A53A	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	53					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CCCAGGATGCCCAGCGGCTCG	0.637000													11	41					0	0	1	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151205035	151205035	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151205035C>T	ENST00000409426.1	+	6	904	c.459C>T	c.(457-459)ctC>ctT	p.L153L	PIP5K1A_ENST00000441902.2_Silent_p.L153L|PIP5K1A_ENST00000368888.4_Silent_p.L165L|PIP5K1A_ENST00000368890.4_Silent_p.L152L			Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	165	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			breast(1)|central_nervous_system(1)|ovary(1)|skin(1)|stomach(1)	5	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGTATTCCCTCTGCAGTGAGC	0.428000													28	49					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79579761	79579761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:79579761G>A	ENST00000372391.2	-	16	3423	c.3418C>T	c.(3418-3420)Ccg>Tcg	p.P1140S	DLG5_ENST00000372388.2_Missense_Mutation_p.P800S|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1140					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CCACTGGCCGGGACACACTTC	0.607000													19	76					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117853292	117853292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117853292C>T	ENST00000350763.4	-	2	417	c.6G>A	c.(4-6)ggG>ggA	p.G2G	TNC_ENST00000341037.4_Silent_p.G2G|TNC_ENST00000542877.1_Silent_p.G2G|TNC_ENST00000340094.3_Silent_p.G2G|TNC_ENST00000537320.1_Silent_p.G2G|TNC_ENST00000535648.1_Silent_p.G2G|TNC_ENST00000423613.2_Silent_p.G2G|TNC_ENST00000345230.3_Silent_p.G2G|TNC_ENST00000346706.3_Silent_p.G2G	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2					cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GAGTCATGGCCCCCATGGTGG	0.557000													21	18					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50500108	50500108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50500108C>T	ENST00000301149.3	+	4	630	c.398C>T	c.(397-399)tCg>tTg	p.S133L	GPD1_ENST00000548814.1_Missense_Mutation_p.S110L|GPD1_ENST00000547190.1_3'UTR	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	133					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	AAGCTCATCTCGGAAGTGATT	0.617000													13	18					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818883	159818883	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159818883G>A	ENST00000497452.1	-	0	517																											ggagaaaacggagaagagtta	0.463000													116	369					0	0	1	0	0
ZNF525	170958	broad.mit.edu	37	19	53885197	53885197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53885197C>T	ENST00000467003.1	+	4	1458	c.1257C>T	c.(1255-1257)acC>acT	p.T419T	ZNF525_ENST00000593918.1_Intron|ZNF525_ENST00000475179.1_Intron|ZNF525_ENST00000474037.1_Silent_p.T455T|ZNF525_ENST00000355326.3_Silent_p.T173T					zinc finger protein 525											endometrium(3)|kidney(3)|lung(3)	9						TATCCCTTACCTGCCATTGTA	0.378000													21	39					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53413730	53413730	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53413730G>A	ENST00000371514.3	+	3	345	c.177G>A	c.(175-177)caG>caA	p.Q59Q	SCP2_ENST00000528311.1_5'UTR|SCP2_ENST00000407246.2_Intron|SCP2_ENST00000371509.4_Silent_p.Q59Q|SCP2_ENST00000371513.5_Silent_p.Q59Q	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	59					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						CAGTGGACCAGGCATGTGTTG	0.348000													46	178					0	0	1	0	0
BTNL3	10917	broad.mit.edu	37	5	180432565	180432565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180432565G>A	ENST00000342868.6	+	8	1278	c.1094G>A	c.(1093-1095)gGg>gAg	p.G365E		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	365	B30.2/SPRY.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			GTAGACAGGGGGAAGAACAAT	0.478000													18	60					0	0	1	0	0
IGKJ5	28946	broad.mit.edu	37	2	89160099	89160099	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89160099C>T	ENST00000452230.1	-	0	39				IGKJ5_ENST00000390238.2_RNA|AC096579.7_ENST00000430694.1_RNA																							CCAGTCGTGTCCCTTGGCCGA	0.383000													23	54					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187153312	187153312	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187153312C>A	ENST00000264690.6	+	3	277	c.90C>A	c.(88-90)ttC>ttA	p.F30L	KLKB1_ENST00000513864.1_Missense_Mutation_p.F30L	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	30	Apple 1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		AAAACGCCTTCTTCAGAGGTG	0.383000													50	117					3.28156e-27	3.30365e-27	1	1	0
EPHA3	2042	broad.mit.edu	37	3	89448644	89448644	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:89448644C>T	ENST00000452448.2	+	7	1695	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	EPHA3_ENST00000336596.2_Intron|EPHA3_ENST00000494014.1_Intron	NM_182644.2	NP_872585.1	P29320	EPHA3_HUMAN	EPH receptor A3	0						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGTATTATTTCAATGCAGTCT	0.408000										TSP Lung(6;0.00050)			16	37					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179529435	179529435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179529435C>T	ENST00000589042.1	-	167	36372	c.36148G>A	c.(36148-36150)Gaa>Aaa	p.E12050K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10198	Ig-like 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTTCTTTTCAGGGACAATT	0.383000													12	46					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814408	106814408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106814408G>A	ENST00000407775.2	+	8	2348	c.2098G>A	c.(2098-2100)Gaa>Aaa	p.E700K	ZFPM2_ENST00000520492.1_Missense_Mutation_p.E568K|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.E431K|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.E568K|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	700					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CAGCCGGCACGAAACATACAT	0.488000													13	27					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189864087	189864087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189864087C>T	ENST00000304636.3	+	30	2269	c.2099C>T	c.(2098-2100)cCc>cTc	p.P700L	COL3A1_ENST00000317840.5_Missense_Mutation_p.P700L	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	700	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGAGCTGGTCCCCCTGGTCCC	0.473000													4	17					0	0	1	0	0
RPL18	6141	broad.mit.edu	37	19	49119388	49119388	+	Silent	SNP	G	G	A	rs138053229	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49119388G>A	ENST00000549273.1	-	5	402	c.369C>T	c.(367-369)ttC>ttT	p.F123F	RPL18_ENST00000552588.1_Silent_p.F94F|RPL18_ENST00000550645.1_Intron|RPL18_ENST00000549920.1_Silent_p.F123F			Q07020	RL18_HUMAN	ribosomal protein L18	123					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			cervix(1)|kidney(2)	3		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)		CCAGCTGGTCGAAAGTGAGGA	0.642000													20	54					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409973	105409973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105409973C>T	ENST00000333244.5	-	7	11934	c.11815G>A	c.(11815-11817)Gag>Aag	p.E3939K	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3939						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTGGGGCCTCGACGTCCACC	0.597000													90	288					0	0	1	0	0
IFI27L2	83982	broad.mit.edu	37	14	94594942	94594942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94594942G>A	ENST00000556727.1	-	3	260	c.33C>T	c.(31-33)tcC>tcT	p.S11S	IFI27L2_ENST00000238609.3_Silent_p.S36S			Q9H2X8	I27L2_HUMAN	interferon, alpha-inducible protein 27-like 2	36						integral to membrane		p.S36S(1)		breast(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	8						CTGCTATGGAGGACGCGGCGA	0.637000													4	51					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3679789	3679789	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3679789G>A	ENST00000294600.2	+	7	1156	c.1072G>A	c.(1072-1074)Ggt>Agt	p.G358S		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	358	Glu-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TGCCTGGGGAGGTGTGAGCCA	0.672000													5	5					0	0	1	0	0
KCNK15	60598	broad.mit.edu	37	20	43379197	43379197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43379197C>T	ENST00000372861.3	+	2	842	c.711C>T	c.(709-711)gcC>gcT	p.A237A		NM_022358.3	NP_071753.2	Q9H427	KCNKF_HUMAN	potassium channel, subfamily K, member 15	237						integral to membrane	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				TCATTGGCGCCTTCCTCAACC	0.706000													15	83					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152193650	152193650	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152193650G>A	ENST00000368801.2	-	3	530	c.455C>T	c.(454-456)aCt>aTt	p.T152I	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	152					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TATGGATTCAGTCCCAGGTTT	0.438000													10	125					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12341345	12341345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12341345C>T	ENST00000256186.2	+	4	1820	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	510					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		CCCCAGCTTTCCTTGCAGTTA	0.517000													42	98					0	0	1	0	0
TFG	10342	broad.mit.edu	37	3	100467173	100467173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100467173C>T	ENST00000240851.4	+	8	1341	c.1001C>T	c.(1000-1002)tCt>tTt	p.S334F	TFG_ENST00000476228.1_Missense_Mutation_p.S330F|TFG_ENST00000418917.2_Missense_Mutation_p.S330F|TFG_ENST00000490574.1_Missense_Mutation_p.S334F|TFG_ENST00000481203.1_3'UTR	NM_001195478.1|NM_001195479.1|NM_006070.5	NP_001182407.1|NP_001182408.1|NP_006061.2	Q92734	TFG_HUMAN	TRK-fused gene	334					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/NR4A3(2)|TFG/NTRK1_ENST00000392302(5)|TFG/ALK(9)	large_intestine(4)|lung(2)|prostate(1)|stomach(1)	8						GCCCAAACTTCTCAGCCTACT	0.522000			T	"""NTRK1, ALK"""	"""papillary thyroid, ALCL, NSCLC"""								34	109					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125805353	125805353	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:125805353C>T	ENST00000346248.5	-	2	1018	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	CHST15_ENST00000435907.1_Missense_Mutation_p.E126K|CHST15_ENST00000421115.1_Missense_Mutation_p.E126K	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	126					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	p.E126K(1)		endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						CTTGGGTTTTCGCTGTCCATC	0.438000													82	178					0	0	1	0	0
MYF6	4618	broad.mit.edu	37	12	81101534	81101534	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81101534C>T	ENST00000228641.3	+	1	258	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	12					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						GCTCCTATTTCTTCTACTTGG	0.493000													36	88					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5860039	5860039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5860039G>A	ENST00000356134.5	-	12	1215	c.1144C>T	c.(1144-1146)Ctt>Ttt	p.L382F	ANO2_ENST00000327087.8_Missense_Mutation_p.L381F|ANO2_ENST00000546188.1_Missense_Mutation_p.L382F	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	386						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CATCCATAAAGAAACACAATC	0.353000													10	21					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183778095	183778095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183778095C>T	ENST00000318351.1	+	9	1333	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	433						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ACCTGCTCTTCATGGCCTCCT	0.567000													66	175					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68992794	68992794	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68992794G>A	ENST00000288368.4	+	16	2036	c.1759G>A	c.(1759-1761)Gaa>Aaa	p.E587K	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	587					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AAAAGTTGTGGAAAATGTTAT	0.318000													4	44					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179587780	179587780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179587780G>A	ENST00000444136.1	+	5	1128	c.878G>A	c.(877-879)gGa>gAa	p.G293E	TDRD5_ENST00000367614.1_Missense_Mutation_p.G293E|TDRD5_ENST00000294848.8_Missense_Mutation_p.G293E	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	293					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GGACCTGGAGGAACTATCAGT	0.313000													30	83					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36291092	36291092	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36291092G>C	ENST00000301175.3	-	11	1476	c.1459C>G	c.(1459-1461)Ccc>Gcc	p.P487A		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	487					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGCCATAGGGAATGGACTTA	0.557000													4	8					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100361804	100361804	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100361804G>A	ENST00000542585.1	+	0	4400				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCCCTGGAGGGAACCCCACTT	0.617000													4	14					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94488981	94488981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:94488981G>A	ENST00000375708.3	-	8	1426	c.1228C>T	c.(1228-1230)Ccc>Tcc	p.P410S	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Missense_Mutation_p.P270S	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	410					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GCGATGCTGGGGACCAAGATG	0.498000													29	50					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40362893	40362893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40362893G>A	ENST00000221347.6	-	32	15184	c.15177C>T	c.(15175-15177)ccC>ccT	p.P5059P		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5059	VWFD 12.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGGTCGCGAAGGGGCCCTGGG	0.652000													49	118					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56538970	56538970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56538970G>A	ENST00000390649.3	+	7	1371	c.1371G>A	c.(1369-1371)gcG>gcA	p.A457A		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	457	NACHT.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GGTTGCGTGCGATCATGAACA	0.597000													9	27					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101194818	101194818	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:101194818G>A	ENST00000294728.2	+	5	1185	c.1084G>A	c.(1084-1086)Gag>Aag	p.E362K	VCAM1_ENST00000370119.4_Missense_Mutation_p.E300K|VCAM1_ENST00000370115.1_Intron|VCAM1_ENST00000347652.2_Intron	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	362	Ig-like C2-type 4.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GGTGAGGAGTGAGGGGACCAA	0.507000													56	125					0	0	1	0	0
KLK3	354	broad.mit.edu	37	19	51361366	51361366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51361366C>T	ENST00000360617.3	+	3	288	c.288C>T	c.(286-288)ttC>ttT	p.F96F	KLK3_ENST00000326003.2_Silent_p.F96F|KLK3_ENST00000593997.1_Silent_p.F96F|KLK3_ENST00000595952.1_Intron|KLK3_ENST00000597483.1_Intron			P07288	KLK3_HUMAN	kallikrein-related peptidase 3	96	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		GCCACAGCTTCCCACACCCGC	0.577000													23	47					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140793597	140793597	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140793597C>T	ENST00000398610.2	+	1	855	c.855C>T	c.(853-855)ttC>ttT	p.F285F	PCDHGA9_ENST00000573521.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATATTCATTCCGAAAATTAC	0.418000													8	13					0	0	1	0	0
PRRT2	112476	broad.mit.edu	37	16	29824999	29824999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29824999C>T	ENST00000300797.6	+	2	798	c.624C>T	c.(622-624)tcC>tcT	p.S208S	PRRT2_ENST00000567659.1_Silent_p.S208S|PRRT2_ENST00000567551.1_Intron|PRRT2_ENST00000358758.7_Silent_p.S208S|AC009133.20_ENST00000569039.1_RNA			Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	208	Pro-rich.				response to biotic stimulus	integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						CAAAAAAATCCCCCCCAGCCA	0.622000													3	11					0	0	1	0	0
SART3	9733	broad.mit.edu	37	12	108919251	108919251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108919251G>A	ENST00000228284.3	-	17	2740	c.2506C>T	c.(2506-2508)Cgg>Tgg	p.R836W	SART3_ENST00000431469.2_Missense_Mutation_p.R800W|FICD_ENST00000546448.1_Intron	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	836	RRM 2.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						TTGCCAGCCCGGTTGGTGACC	0.493000									Porokeratosis				23	46					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35803183	35803183	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35803183G>A	ENST00000361922.4	+	11	1866		c.e11-1		MAG_ENST00000392213.3_Intron|MAG_ENST00000537831.2_Intron	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein						blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTCTCCAATAGTCCAAAGAGG	0.642000													32	133					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55566490	55566490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55566490C>T	ENST00000373965.2	-	36	5298	c.4904G>A	c.(4903-4905)aGg>aAg	p.R1635K	PCDH15_ENST00000414778.1_Missense_Mutation_p.R1632K	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTTTTCAGCCTGTTCCTTAG	0.448000										HNSCC(58;0.16)			97	225					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46825081	46825081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46825081G>A	ENST00000339613.2	+	10	1280	c.1025G>A	c.(1024-1026)aGc>aAc	p.S342N	HIF3A_ENST00000244303.6_Missense_Mutation_p.S329N|HIF3A_ENST00000420102.2_Missense_Mutation_p.S347N|AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000600383.1_Missense_Mutation_p.S329N|HIF3A_ENST00000472815.1_Missense_Mutation_p.S329N|HIF3A_ENST00000300862.3_Missense_Mutation_p.S396N|HIF3A_ENST00000377670.4_Missense_Mutation_p.S398N			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		CCTTCCCTGAGCGAGGCTGCC	0.682000													21	93					0	0	1	0	0
CRYGC	1420	broad.mit.edu	37	2	208993030	208993030	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:208993030C>T	ENST00000282141.3	-	3	459	c.422G>A	c.(421-423)gGg>gAg	p.G141E		NM_020989.3	NP_066269.1	P07315	CRGC_HUMAN	crystallin, gamma C	141	Beta/gamma crystallin 'Greek key' 4.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens			NS(1)|endometrium(1)|large_intestine(2)|lung(5)	9				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		GTATTGCCGCCCCCGGTAGTT	0.632000													37	87					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27190614	27190614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27190614G>A	ENST00000380036.4	+	10	1857	c.1415G>A	c.(1414-1416)gGg>gAg	p.G472E	TEK_ENST00000519097.1_Missense_Mutation_p.G325E|TEK_ENST00000406359.4_Missense_Mutation_p.G429E	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	472	Fibronectin type-III 1.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CCTTACTTTGGGGATGGACCA	0.423000													43	133					0	0	1	0	0
APOBR	55911	broad.mit.edu	37	16	28508889	28508889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28508889G>A	ENST00000564831.1	+	2	2560	c.2527G>A	c.(2527-2529)Gcc>Acc	p.A843T	APOBR_ENST00000431282.1_Missense_Mutation_p.A834T|APOBR_ENST00000328423.5_Missense_Mutation_p.A834T	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	834	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						GCGGGTAGAGGCCGAGGAATC	0.662000													4	10					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49848734	49848734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49848734C>T	ENST00000333486.3	-	9	1252	c.1094G>A	c.(1093-1095)gGt>gAt	p.G365D		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	365	2 approximate repeats.			GVLSPMVAMLGAVAAQEVLKAISR -> RCLEPMVACWVSS CPGSAEGNLQ (in Ref. 1; AAA75388 and 2; AAG49557).	ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AGCTACTGCACCCAGCATGGC	0.597000													22	59					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322559	55322559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55322559C>T	ENST00000314644.2	+	1	777	c.777C>T	c.(775-777)atC>atT	p.I259I		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GTGGGTTTATCTGCATCATAA	0.468000										HNSCC(20;0.049)			35	60					0	0	1	0	0
GTPBP1	9567	broad.mit.edu	37	22	39125543	39125543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39125543C>T	ENST00000216044.5	+	11	2026	c.1793C>T	c.(1792-1794)cCc>cTc	p.P598L		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	598					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					AAAAAGGGCCCCCTGACGAAA	0.607000													7	22					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952815	54952815	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54952815G>A	ENST00000273286.5	-	3	871	c.709C>T	c.(709-711)Cct>Tct	p.P237S	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.P161S|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000490478.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	237						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		ACTGGATCAGGAGCAGGAAGA	0.597000													11	21					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148669	34148669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34148669C>T	ENST00000346193.3	-	1	1778	c.1727G>A	c.(1726-1728)cGa>cAa	p.R576Q		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	576								p.R576Q(2)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GTAGGATGCTCGAATCTTGGG	0.512000													15	30					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29917838	29917838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29917838G>A	ENST00000389048.3	-	3	1736	c.830C>T	c.(829-831)tCc>tTc	p.S277F	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	277	MAM 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CAGTGGAGGGGAATACTCCAG	0.567000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				30	79					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3886707	3886707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3886707G>A	ENST00000319331.3	+	2	1143	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	128						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		GCATTTGGAGGAAAATCAGAT	0.418000													26	67					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41276491	41276491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41276491G>A	ENST00000361937.3	-	33	4405	c.3981C>T	c.(3979-3981)atC>atT	p.I1327I	INO80_ENST00000401393.3_Silent_p.I1327I			Q9ULG1	INO80_HUMAN	INO80 complex subunit	1327	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GAACAAATGGGATCACCAGGT	0.478000													17	51					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19295170	19295170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:19295170C>T	ENST00000328405.2	+	2	367	c.101C>T	c.(100-102)gCc>gTc	p.A34V		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	34	PAS.					integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CTTGCCAATGCCCAGGTGGCT	0.428000													69	157					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32020752	32020752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32020752G>A	ENST00000375244.3	-	26	9011	c.8810C>T	c.(8809-8811)cCc>cTc	p.P2937L	TNXB_ENST00000375247.2_Missense_Mutation_p.P2935L			P22105	TENX_HUMAN	tenascin XB	2982	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TGTGGGGGCGGGAGTTTCTTC	0.642000													18	52					0	0	1	0	0
IGHV4-28	28400	broad.mit.edu	37	14	106780570	106780570	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106780570G>A	ENST00000390612.2	-	0	365																											GCTTCAGGGAGAACTGGTTCT	0.537000													91	280					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144943768	144943768	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144943768G>A	ENST00000525985.1	-	2	3725	c.3654C>T	c.(3652-3654)acC>acT	p.T1218T				P58107	EPIPL_HUMAN	epiplakin 1	1218						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGCCTCAAGGGTCTCCTGGG	0.716000													7	5					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069366	9069366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9069366G>A	ENST00000397910.4	-	3	18283	c.18080C>T	c.(18079-18081)tCc>tTc	p.S6027F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6029	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGACAGAGGAATGTAGTTT	0.453000													81	154					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126138986	126138986	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126138986G>A	ENST00000393425.1	+	11	1098	c.999G>A	c.(997-999)acG>acA	p.T333T	CCDC37_ENST00000505024.1_Silent_p.T333T|CCDC37_ENST00000352312.1_Silent_p.T332T			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	332								p.T332T(1)		NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		TTCTGCAGACGATGCGGCTGG	0.647000													8	28					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182358140	182358140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182358140C>T	ENST00000397033.2	+	11	1672	c.1242C>T	c.(1240-1242)ttC>ttT	p.F414F		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	414					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CGTCAACCTTCTCACAGGTAA	0.368000													33	83					0	0	1	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6325221	6325221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6325221G>A	ENST00000335585.5	-	9	1175	c.1152C>T	c.(1150-1152)ccC>ccT	p.P384P	PPP2R2C_ENST00000507294.1_Silent_p.P377P|PPP2R2C_ENST00000515571.1_Silent_p.P367P|PPP2R2C_ENST00000382599.4_Silent_p.P384P|PPP2R2C_ENST00000506140.1_Silent_p.P377P	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	384					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						GCACAGCCCGGGGCTTGCTGC	0.617000													9	44					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28619626	28619626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28619626C>T	ENST00000395609.1	-	6	1116	c.358G>A	c.(358-360)Gat>Aat	p.D120N	SULT1A1_ENST00000569554.1_Missense_Mutation_p.D120N|SULT1A1_ENST00000314752.7_Missense_Mutation_p.D120N|SULT1A1_ENST00000350842.4_Intron|SULT1A1_ENST00000395607.1_Missense_Mutation_p.D120N			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	120					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						ACCTTCTGATCCAACAGAGTC	0.577000													28	110					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15061169	15061169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15061169C>T	ENST00000430939.2	-	9	1470	c.1341G>A	c.(1339-1341)ggG>ggA	p.G447G	SLC1A6_ENST00000221742.3_Silent_p.G511G|SLC1A6_ENST00000600144.1_Silent_p.G433G			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	511					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	CAATTGAGTCCCCCAGTACGT	0.562000													22	50					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7762923	7762923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7762923G>A	ENST00000358415.4	+	7	901	c.735G>A	c.(733-735)caG>caA	p.Q245Q	ITIH2_ENST00000379587.4_Silent_p.Q234Q	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	245					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.Q245Q(1)		NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						AAGGACAACAGAAGGTACCCT	0.502000													29	95					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754413	76754413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76754413G>A	ENST00000536229.3	+	1	2732	c.2023G>A	c.(2023-2025)Gac>Aac	p.D675N	SALL3_ENST00000537592.2_Missense_Mutation_p.D808N|SALL3_ENST00000575389.2_Missense_Mutation_p.D808N			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	808					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CATGGAGGACGACGCTGAGCT	0.652000													12	34					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61834329	61834329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61834329C>T	ENST00000280772.1	-	37	6501	c.6310G>A	c.(6310-6312)Gga>Aga	p.G2104R	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2104					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTATCTGTTCCAAAAAAGGAA	0.408000													31	88					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141536282	141536282	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141536282C>T	ENST00000350549.3	-	5	992	c.621G>A	c.(619-621)gtG>gtA	p.V207V	PRSS37_ENST00000438520.1_Silent_p.V207V	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	207	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						TGAAGTGCCCCACCTCGATTC	0.502000													30	83					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64973550	64973550	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:64973550G>A	ENST00000399262.2	-	8	2595	c.2377C>T	c.(2377-2379)Cct>Tct	p.P793S	JMJD1C_ENST00000402544.1_Missense_Mutation_p.P574S|JMJD1C_ENST00000542921.1_Missense_Mutation_p.P611S|JMJD1C_ENST00000399251.1_Missense_Mutation_p.P574S	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	793					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGTAAATGAGGGTGATGAACA	0.507000													15	30					0	0	1	0	0
SCGB1C1	147199	broad.mit.edu	37	11	193729	193729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:193729G>A	ENST00000342878.2	+	2	93	c.73G>A	c.(73-75)Gac>Aac	p.D25N	BET1L_ENST00000410108.1_Intron	NM_145651.2	NP_663626.2	Q8TD33	SG1C1_HUMAN	secretoglobin, family 1C, member 1	25						extracellular region	binding			endometrium(1)|liver(2)|lung(1)|skin(1)	5		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CACAGGGGAGGACAACGATGA	0.572000													12	44					0	0	1	0	0
C5orf54	63920	broad.mit.edu	37	5	159821494	159821494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:159821494G>A	ENST00000408953.3	-	2	1511	c.1004C>T	c.(1003-1005)tCc>tTc	p.S335F	C5orf54_ENST00000523213.1_Missense_Mutation_p.S335F	NM_022090.3	NP_071373.2	Q8IZ13	CE054_HUMAN	chromosome 5 open reading frame 54	335										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	12						ttggcctcgggaaagccacct	0.363000													22	37					0	0	1	0	0
LINC00521	256369	broad.mit.edu	37	14	94467737	94467737	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94467737C>T	ENST00000444118.1	+	0	815					NR_024182.1																						GGCCCCCTTTCCTGCATAGCC	0.652000													5	4					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51330994	51330994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51330994C>T	ENST00000326856.4	-	3	247	c.118G>A	c.(118-120)Gag>Aag	p.E40K	KLK15_ENST00000416184.1_Missense_Mutation_p.E41K|KLK15_ENST00000596931.1_Missense_Mutation_p.E40K|KLK15_ENST00000598239.1_Missense_Mutation_p.E41K|KLK15_ENST00000301421.2_Missense_Mutation_p.E41K	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	41	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CGTCCACGCTCGTAGAGAGCC	0.607000													17	31					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36954816	36954816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36954816C>T	ENST00000262865.4	+	10	1244	c.1155C>T	c.(1153-1155)tcC>tcT	p.S385S	CTD-2308N23.2_ENST00000437016.1_RNA|BPI_ENST00000489102.1_3'UTR	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	385					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				CCCTGGCTTCCCTCTTCCTGA	0.597000													11	29					0	0	1	0	0
RNASE1	6035	broad.mit.edu	37	14	21269835	21269835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21269835C>T	ENST00000397967.4	-	2	899	c.393G>A	c.(391-393)gaG>gaA	p.E131E	RNASE1_ENST00000397970.4_Silent_p.E131E|RNASE1_ENST00000412779.2_Silent_p.E131E|RNASE1_ENST00000340900.3_Silent_p.E131E|RNASE1_ENST00000555698.1_Silent_p.E91E	NM_002933.4	NP_002924.1	P07998	RNAS1_HUMAN	ribonuclease, RNase A family, 1 (pancreatic)	131						extracellular region	nucleic acid binding|pancreatic ribonuclease activity|protein binding			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	5	all_cancers(95;0.00671)	all_lung(585;0.235)	Epithelial(56;9.21e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0126)		TGATGTGTCTCTCCTTCGGGC	0.557000													49	99					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129901135	129901135	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129901135G>A	ENST00000368654.3	-	13	9344	c.8969C>T	c.(8968-8970)tCc>tTc	p.S2990F	MKI67_ENST00000368653.3_Missense_Mutation_p.S2630F	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2990					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGGGGGCAGGGAAGTGTTGCT	0.537000													40	85					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287192	202287192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202287192C>T	ENST00000367278.3	+	18	1850	c.1761C>T	c.(1759-1761)ttC>ttT	p.F587F	LGR6_ENST00000439764.2_Silent_p.F448F|LGR6_ENST00000255432.7_Silent_p.F535F	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	587						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						TGACCGTGTTCGCTGGCGGGC	0.617000													10	112					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81304583	81304583	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81304583G>A	ENST00000555265.1	-	11	1264	c.889C>T	c.(889-891)Caa>Taa	p.Q297*	CEP128_ENST00000216517.6_Nonsense_Mutation_p.Q297*|CEP128_ENST00000281129.3_Nonsense_Mutation_p.Q297*			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	297						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						CCTTCTGATTGATTCAATAAC	0.333000													12	100					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115456614	115456614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115456614G>A	ENST00000369522.3	+	20	1906	c.1666G>A	c.(1666-1668)Gaa>Aaa	p.E556K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E556K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	556					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGCAAGAAGAAAGGATGTT	0.244000													19	48					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66082657	66082657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66082657G>A	ENST00000311330.3	-	1	1858	c.1842C>T	c.(1840-1842)ccC>ccT	p.P614P	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	614	Pro-rich.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	GGAGGGCTGCGGGCTGGGTGG	0.622000													45	67					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5013298	5013298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5013298G>A	ENST00000380390.1	+	6	916	c.700G>A	c.(700-702)Gac>Aac	p.D234N	MMP26_ENST00000300762.1_Missense_Mutation_p.D234N			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	234					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CTGGTATCACGACCCTAGAAC	0.488000													19	51					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500456	90500456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90500456G>A	ENST00000325643.5	+	4	1120	c.1054G>A	c.(1054-1056)Ggt>Agt	p.G352S		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CATGGAGGTAGGTGGCTGCAC	0.562000													23	39					0	0	1	0	0
PIF1	80119	broad.mit.edu	37	15	65108835	65108835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65108835G>A	ENST00000268043.4	-	12	1898	c.1804C>T	c.(1804-1806)Cgc>Tgc	p.R602C	PIF1_ENST00000559239.1_Missense_Mutation_p.R602C|PIF1_ENST00000333425.6_Missense_Mutation_p.R602C			Q9H611	PIF1_HUMAN	PIF1 5'-to-3' DNA helicase	602	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						GGGTCACAGCGAACCGCCATG	0.657000													36	174					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198585	20198585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20198585G>A	ENST00000400331.5	-	5	1707	c.1399C>T	c.(1399-1401)Cat>Tat	p.H467Y	MACC1_ENST00000589011.1_Missense_Mutation_p.H467Y|MACC1_ENST00000332878.4_Missense_Mutation_p.H467Y	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	467					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						AATTGTTGATGAACTACTTCA	0.358000													21	58					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5724456	5724456	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5724456C>T	ENST00000356134.5	-	19	1898	c.1827G>A	c.(1825-1827)ccG>ccA	p.P609P	ANO2_ENST00000327087.8_Silent_p.P608P|ANO2_ENST00000546188.1_Silent_p.P609P	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	613						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GTTCTGTTTTCGGAACCTCTG	0.458000													8	26					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40933038	40933038	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40933038G>A	ENST00000246914.5	+	1	343	c.322G>A	c.(322-324)Ggc>Agc	p.G108S		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	108					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		ACCCCCCGAGGGCACGTGGAC	0.731000													3	11					0	0	1	0	0
GTPBP10	85865	broad.mit.edu	37	7	89983814	89983814	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:89983814C>T	ENST00000222511.6	+	3	336	c.270C>T	c.(268-270)atC>atT	p.I90I	GTPBP10_ENST00000257659.8_Intron	NM_033107.3	NP_149098.2	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 (putative)	90					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(4)	10						ACTGTGAAATCCCTGTGCCTG	0.333000													37	92					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	22078775	22078775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:22078775C>T	ENST00000382254.1	-	5	1097	c.11G>A	c.(10-12)aGg>aAg	p.R4K	CDH12_ENST00000504376.2_Missense_Mutation_p.R4K|CDH12_ENST00000522262.1_Missense_Mutation_p.R4K	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	4					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TAAACAGTTCCTTGTAAGCAT	0.463000										HNSCC(59;0.17)			31	28					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239910	5239910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:5239910G>A	ENST00000274181.7	+	16	2533	c.2395G>A	c.(2395-2397)Ggg>Agg	p.G799R		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	799	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CTACCTGAATGGGCACTGGAC	0.522000													33	107					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89347331	89347331	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89347331G>A	ENST00000301030.4	-	9	6079	c.5619C>T	c.(5617-5619)gtC>gtT	p.V1873V	ANKRD11_ENST00000378330.2_Silent_p.V1873V	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1873	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GGGTGACAGTGACAACGGCAG	0.612000													21	60					0	0	1	0	0
PANX3	116337	broad.mit.edu	37	11	124489501	124489501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124489501G>A	ENST00000284288.2	+	4	916	c.849G>A	c.(847-849)ttG>ttA	p.L283L		NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3	283					protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		ACACCATATTGGTTCCAGTGA	0.453000													23	66					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33165256	33165256	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:33165256C>T	ENST00000280979.4	+	9	3110	c.2940C>T	c.(2938-2940)tcC>tcT	p.S980S	AKAP6_ENST00000557272.1_Silent_p.S980S|AKAP6_ENST00000557354.1_Silent_p.S980S	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	980					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ACATGGAGTCCCTTGTGATGG	0.468000													24	53					0	0	1	0	0
TFAP2A	7020	broad.mit.edu	37	6	10410431	10410431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:10410431G>A	ENST00000379613.3	-	2	445	c.189C>T	c.(187-189)ccC>ccT	p.P63P	TFAP2A_ENST00000482890.1_Silent_p.P61P|RP1-290I10.6_ENST00000420777.1_RNA|TFAP2A_ENST00000379608.3_Silent_p.P55P|TFAP2A_ENST00000319516.4_Silent_p.P57P|TFAP2A_ENST00000497266.1_Intron|TFAP2A_ENST00000379604.2_Silent_p.P61P			P05549	AP2A_HUMAN	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	61	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	13	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				TAGGCTGGTAGGGTGGGGGGA	0.657000													15	39					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325516	150325516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150325516C>T	ENST00000328902.5	-	3	386	c.170G>A	c.(169-171)gGa>gAa	p.G57E	GIMAP6_ENST00000493969.1_Intron	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	57							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GATGCTGTTTCCTGTTGCACT	0.542000													132	356					0	0	1	0	0
HAPLN1	1404	broad.mit.edu	37	5	82937540	82937540	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82937540G>A	ENST00000274341.4	-	5	1690	c.840C>T	c.(838-840)ctC>ctT	p.L280L		NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	280	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CACCATCATTGAGACAAGCTT	0.512000													74	194					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23526958	23526958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:23526958G>A	ENST00000296682.3	+	11	1943	c.1761G>A	c.(1759-1761)cgG>cgA	p.R587R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	587					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGTGTGGGCGGGGCTTTAGCT	0.607000										HNSCC(3;0.000094)			25	87					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168114084	168114084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168114084C>T	ENST00000519560.1	-	30	3633	c.3214G>A	c.(3214-3216)Gag>Aag	p.E1072K	SLIT3_ENST00000332966.8_Missense_Mutation_p.E1079K|SLIT3_ENST00000404867.3_Missense_Mutation_p.E1072K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1072	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGTCTGTCTCACAGAGCTTC	0.597000													20	33					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149486857	149486857	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149486857C>T	ENST00000378016.2	+	0	4631							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTGCCTGGCCCCTCCCCAGGC	0.672000													19	38					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64873562	64873562	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64873562G>A	ENST00000533854.1	+	2	349	c.112G>A	c.(112-114)Gag>Aag	p.E38K	CACNG5_ENST00000169565.3_Missense_Mutation_p.E38K|CACNG5_ENST00000307139.3_Missense_Mutation_p.E38K			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	38					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GTACCTGGAGGAGGGTGTGAT	0.622000													22	73					0	0	1	0	0
ZNF625	90589	broad.mit.edu	37	19	12256752	12256752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12256752C>T	ENST00000355738.1	-	4	630	c.281G>A	c.(280-282)gGg>gAg	p.G94E	ZNF625_ENST00000439556.2_Missense_Mutation_p.G160E|ZNF625_ENST00000542938.1_Missense_Mutation_p.G94E|ZNF625_ENST00000455799.1_3'UTR|ZNF625-ZNF20_ENST00000430024.1_Intron			Q96I27	ZN625_HUMAN	zinc finger protein 625	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(4)|skin(2)	14						ATAAGGTTTCCCCCCAGTGTG	0.423000													19	146					0	0	1	0	0
DDX39B	7919	broad.mit.edu	37	6	31503091	31503091	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31503091G>A	ENST00000453105.2	-	5	833	c.647C>T	c.(646-648)cCc>cTc	p.P216L	DDX39B_ENST00000415382.2_Intron|DDX39B_ENST00000376177.2_Intron|ATP6V1G2-DDX39B_ENST00000376185.1_Intron|DDX39B_ENST00000417556.2_Intron|DDX39B_ENST00000396172.1_Intron|DDX39B_ENST00000458640.1_Intron			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0	Helicase ATP-binding.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						ggcgaggaaggggaggaggca	0.542000													18	39					0	0	1	0	0
C11orf16	56673	broad.mit.edu	37	11	8947545	8947545	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8947545C>T	ENST00000326053.5	-	5	775	c.669G>A	c.(667-669)gaG>gaA	p.E223E	C11orf16_ENST00000525780.1_Silent_p.E223E	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	223										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		TGTGCAGCCTCTCCACAGCCT	0.557000													32	100					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155200514	155200514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155200514C>T	ENST00000460012.1	-	23	3568	c.3211G>A	c.(3211-3213)Gaa>Aaa	p.E1071K	PLCH1_ENST00000334686.6_Missense_Mutation_p.E1071K|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000340059.7_Missense_Mutation_p.E1109K|PLCH1_ENST00000414191.1_Missense_Mutation_p.E1071K			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1109					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTACCCTTTTCCTTGATTTTC	0.468000													53	100					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134920412	134920412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134920412C>T	ENST00000398015.3	+	12	2597	c.2227C>T	c.(2227-2229)Cgg>Tgg	p.R743W	EPHB1_ENST00000493838.1_Missense_Mutation_p.R304W	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	743	Protein kinase.		R -> Q (in a gastric adenocarcinoma sample; somatic mutation).			integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.R743W(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TTATGTGCATCGGGACCTGGC	0.547000													40	182					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913431	6913431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6913431G>A	ENST00000299459.2	-	1	399	c.301C>T	c.(301-303)Ctt>Ttt	p.L101F		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAAAAGAGAAGTCGAGCTGCG	0.478000													21	64					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91739130	91739130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91739130C>T	ENST00000389857.6	-	30	6012	c.5926G>A	c.(5926-5928)Ggg>Agg	p.G1976R	CCDC88C_ENST00000331194.7_Missense_Mutation_p.G500R	NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1976					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				GCCGGAAGCCCCTCACTGCAG	0.711000													5	25					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76372213	76372213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76372213C>T	ENST00000407242.2	-	3	666	c.424G>A	c.(424-426)Gag>Aag	p.E142K	LRRC32_ENST00000260061.5_Missense_Mutation_p.E142K|AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000404995.1_Missense_Mutation_p.E142K|LRRC32_ENST00000464145.1_Intron	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	142						integral to plasma membrane		p.E142*(1)		endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						AGCAGCCGCTCCAGCAGGCCG	0.687000													15	41					0	0	1	0	0
RNASE12	493901	broad.mit.edu	37	14	21058675	21058675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21058675G>A	ENST00000556526.1	-	1	307	c.208C>T	c.(208-210)Cat>Tat	p.H70Y	RNASE11_ENST00000335950.4_5'UTR|RP11-14J7.6_ENST00000556487.1_RNA|RP11-14J7.6_ENST00000554529.1_RNA|RP11-14J7.6_ENST00000553604.1_RNA|RP11-14J7.6_ENST00000554993.1_RNA|AL163195.3_ENST00000555283.1_RNA	NM_001024822.2	NP_001019993.1	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	70						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			kidney(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		GGCCTCTCATGGATGAAGACA	0.438000													11	123					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82421702	82421702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:82421702C>T	ENST00000370728.1	+	13	2608	c.1963C>T	c.(1963-1965)Ctt>Ttt	p.L655F	LPHN2_ENST00000359929.3_Missense_Mutation_p.L642F|LPHN2_ENST00000394879.1_Missense_Mutation_p.L642F|LPHN2_ENST00000370730.1_Missense_Mutation_p.L655F|LPHN2_ENST00000271029.4_Missense_Mutation_p.L655F|LPHN2_ENST00000370715.1_Missense_Mutation_p.L642F|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000335786.5_Missense_Mutation_p.L655F|LPHN2_ENST00000370725.1_Missense_Mutation_p.L655F|LPHN2_ENST00000370723.1_Missense_Mutation_p.L642F|LPHN2_ENST00000370721.1_Missense_Mutation_p.L580F|LPHN2_ENST00000370713.1_Missense_Mutation_p.L642F|LPHN2_ENST00000319517.6_Missense_Mutation_p.L642F|LPHN2_ENST00000370717.2_Missense_Mutation_p.L655F|LPHN2_ENST00000370727.1_Missense_Mutation_p.L655F			O95490	LPHN2_HUMAN	latrophilin 2	655					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AGCTGACAATCTTTTAGAACC	0.348000													12	68					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168678436	168678436	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168678436C>T	ENST00000519560.1	-	2	644	c.225G>A	c.(223-225)agG>agA	p.R75R	SLIT3_ENST00000521130.1_5'UTR|SLIT3_ENST00000332966.8_Silent_p.R75R|SLIT3_ENST00000404867.3_Silent_p.R75R	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	75					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTTGGTGATCCTGGTGATAT	0.433000													40	77					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36596150	36596150	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:36596150C>T	ENST00000299440.5	+	2	1408	c.1296C>T	c.(1294-1296)tcC>tcT	p.S432S		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	432					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				ATGTGAAGTCCGTGTGCATGA	0.567000									Familial Hemophagocytic Lymphohistiocytosis				20	45					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52886564	52886564	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52886564C>T	ENST00000330722.6	-	1	477	c.409G>A	c.(409-411)Gag>Aag	p.E137K		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	137	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACGGTGACCTCTTGGATGCCT	0.632000													22	58					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169432679	169432679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169432679G>A	ENST00000261509.6	+	2	235	c.24G>A	c.(22-24)gaG>gaA	p.E8E	PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Silent_p.E8E	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	8					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCTCCCATGAGTCCTTCTATG	0.478000									Pancreatic Cancer, Familial Clustering of				26	71					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182359477	182359477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182359477C>T	ENST00000397033.2	+	12	1707	c.1277C>T	c.(1276-1278)tCg>tTg	p.S426L		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	426					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATCAGCAAATCGTTAAGTATG	0.308000													41	93					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21102957	21102957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21102957C>T	ENST00000377122.4	-	23	2653	c.2257G>A	c.(2257-2259)Gac>Aac	p.D753N	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	753					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TGTTTATGGTCCTGGGTATAT	0.328000													15	64					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72071175	72071175	+	Silent	SNP	G	G	A	rs112803189		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72071175G>A	ENST00000265381.4	-	8	1998	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	592	PID.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle		p.F592F(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						CCTCAGACTCGAAGACGTGGC	0.522000													44	157					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374539	31374539	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31374539G>A	ENST00000268296.4	+	14	1675	c.1554G>A	c.(1552-1554)tgG>tgA	p.W518*	ITGAX_ENST00000562522.1_Nonsense_Mutation_p.W518*	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	518					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GCCACCCCTGGGGTCGCTTTG	0.637000													56	101					0	0	1	0	0
PAMR1	25891	broad.mit.edu	37	11	35463233	35463233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:35463233C>T	ENST00000378880.2	-	7	1274	c.829G>A	c.(829-831)Gaa>Aaa	p.E277K	PAMR1_ENST00000278360.3_Missense_Mutation_p.E294K|PAMR1_ENST00000532848.1_Missense_Mutation_p.E237K|PAMR1_ENST00000378878.3_Missense_Mutation_p.E166K	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	277					proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						CAGTTTCTTTCTTCAAGGACT	0.398000													23	40					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35654817	35654817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35654817G>A	ENST00000440995.2	+	7	967	c.967G>A	c.(967-969)Gaa>Aaa	p.E323K	SPEF2_ENST00000282469.6_Missense_Mutation_p.E323K|SPEF2_ENST00000356031.3_Missense_Mutation_p.E323K|SPEF2_ENST00000509059.1_Missense_Mutation_p.E323K			Q9C093	SPEF2_HUMAN	sperm flagellar 2	323					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AATAGCCCACGAAGCACAAGA	0.363000													22	103					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119736782	119736782	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119736782G>A	ENST00000379735.5	-	5	768	c.497C>T	c.(496-498)cCt>cTt	p.P166L	SEC24D_ENST00000419654.2_5'UTR|SEC24D_ENST00000280551.6_Missense_Mutation_p.P166L	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	166	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						TTGAGATCCAGGCTGCAAAAT	0.582000													18	50					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164761751	164761751	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:164761751C>T	ENST00000420696.2	+	3	474	c.286C>T	c.(286-288)Cag>Tag	p.Q96*	PBX1_ENST00000401534.1_Nonsense_Mutation_p.Q96*|PBX1_ENST00000540246.1_5'UTR|PBX1_ENST00000560641.1_5'UTR|PBX1_ENST00000540236.1_Nonsense_Mutation_p.Q96*|PBX1_ENST00000559240.1_Nonsense_Mutation_p.Q96*|PBX1_ENST00000367897.1_Nonsense_Mutation_p.Q96*	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	96					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						CCGAGGAGCCCAGGAGGAGGA	0.532000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								14	35					0	0	1	0	0
GGTLC1	92086	broad.mit.edu	37	20	23965900	23965900	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23965900C>T	ENST00000335694.4	-	6	835	c.631G>A	c.(631-633)Gca>Aca	p.A211T	GGTLC1_ENST00000286890.4_Missense_Mutation_p.A211T|GGTLC1_ENST00000278765.4_Missense_Mutation_p.A211T	NM_178311.2	NP_842563.1	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	211							gamma-glutamyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15						GAGGCAGCTGCCCAGCCACCA	0.592000													27	76					0	0	1	0	0
CCDC24	149473	broad.mit.edu	37	1	44457929	44457929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44457929G>A	ENST00000372318.3	+	3	343	c.172G>A	c.(172-174)Gcc>Acc	p.A58T	SLC6A9_ENST00000372307.3_Intron|CCDC24_ENST00000486064.1_3'UTR|SLC6A9_ENST00000372306.3_Intron	NM_152499.1	NP_689712.1	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	58										endometrium(3)|large_intestine(2)|lung(3)|stomach(1)	9	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				ATCCTCTCAAGCCCCCAGCTC	0.632000													38	158					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659121	196659121	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196659121G>A	ENST00000312428.6	-	57	10757	c.10657C>T	c.(10657-10659)Cga>Tga	p.R3553*	DNAH7_ENST00000409063.1_Nonsense_Mutation_p.R36*	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3553	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGGTATGATCGAATGATATTA	0.453000													50	103					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16035627	16035627	+	Silent	SNP	G	G	A	rs149071621	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16035627G>A	ENST00000326742.7	-	5	592	c.591C>T	c.(589-591)ctC>ctT	p.L197L	CYP4F11_ENST00000402119.3_Silent_p.L197L|CYP4F11_ENST00000248041.7_Silent_p.L197L			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	197					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						CCAAGGTCATGAGGCTGATGT	0.527000													41	75					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049518	9049518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9049518C>T	ENST00000397910.4	-	5	32316	c.32113G>A	c.(32113-32115)Gaa>Aaa	p.E10705K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10707	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCATCTGATTCATGATGAGAA	0.473000													16	255					0	0	1	0	0
ZGLP1	100125288	broad.mit.edu	37	19	10419190	10419190	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10419190G>A	ENST00000403903.3	-	1	1366	c.168C>T	c.(166-168)gcC>gcT	p.A56A	CTD-2369P2.10_ENST00000452032.2_3'UTR|FDX1L_ENST00000541276.1_3'UTR|ZGLP1_ENST00000403352.1_5'UTR	NM_001103167.1	NP_001096637.1	P0C6A0	ZGLP1_HUMAN	zinc finger, GATA-like protein 1	56					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(2)|ovary(1)	6						GGAAGCACAGGGCGGTGACCG	0.667000													6	11					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133900636	133900636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133900636C>T	ENST00000220616.4	+	10	2624	c.2584C>T	c.(2584-2586)Ctc>Ttc	p.L862F	TG_ENST00000377869.1_Missense_Mutation_p.L862F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	862	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGAGAATATCCTCCTGGAGCC	0.537000													13	46					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11070974	11070974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11070974G>A	ENST00000287766.4	+	12	1680	c.1259G>A	c.(1258-1260)aGa>aAa	p.R420K	SLC6A1_ENST00000536032.1_Missense_Mutation_p.R242K	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	420					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CGCAACCGCAGAGAGCTCTTC	0.567000													9	28					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233274432	233274432	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233274432C>T	ENST00000295453.3	+	11	1501	c.1449C>T	c.(1447-1449)ttC>ttT	p.F483F		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	483					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	TCATGGCCTTCGCCGCCTGCC	0.751000													14	25					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120889255	120889255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120889255C>T	ENST00000263713.5	+	18	1777	c.1563C>T	c.(1561-1563)tcC>tcT	p.S521S	EPB41L5_ENST00000443902.2_Silent_p.S521S|EPB41L5_ENST00000452780.1_Silent_p.S521S	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	521						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						CTTTGCTGTCCCCTCGATCCA	0.413000													20	71					0	0	1	0	0
GZMA	3001	broad.mit.edu	37	5	54403622	54403622	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54403622G>A	ENST00000274306.6	+	3	251	c.215_splice	c.e3-1	p.L72_splice		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	72	Peptidase S1.			NL -> IP (in Ref. 5; no nucleotide entry).	cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CTGTTCTCAGGAACAAAAGGT	0.388000													21	69					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111564691	111564691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111564691C>T	ENST00000393934.3	+	4	1460	c.890C>T	c.(889-891)cCt>cTt	p.P297L	PHLDB2_ENST00000393923.3_5'UTR|PLCXD2_ENST00000477665.1_3'UTR	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	0					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						CCAGTTTATCCTTTGAGATTC	0.468000													34	93					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14832636	14832636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14832636C>T	ENST00000261170.3	-	6	921	c.785G>A	c.(784-786)cGa>cAa	p.R262Q	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	262					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity	p.R262L(1)		breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AGCCACTGCTCGGTCACCCTT	0.418000													40	99					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16235856	16235856	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16235856C>T	ENST00000375759.3	+	4	1126	c.922C>T	c.(922-924)Cga>Tga	p.R308*		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	308	Ser-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TTCTCCAGCTCGATCAGTTCA	0.443000													19	232					0	0	1	0	0
YIPF3	25844	broad.mit.edu	37	6	43481164	43481164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43481164G>A	ENST00000372422.2	-	5	649	c.467C>T	c.(466-468)cCt>cTt	p.P156L	YIPF3_ENST00000506469.1_Missense_Mutation_p.P162L	NM_015388.3	NP_056203.2	Q9GZM5	YIPF3_HUMAN	Yip1 domain family, member 3	156					cell differentiation	integral to membrane|plasma membrane|transport vesicle				large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)	9	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			CAGCATGAGAGGTCCATAGAG	0.478000													19	33					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38937179	38937179	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38937179C>T	ENST00000355481.4	+	8	830	c.699C>T	c.(697-699)tcC>tcT	p.S233S	RYR1_ENST00000360985.3_Silent_p.S233S|RYR1_ENST00000359596.3_Silent_p.S233S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	233	MIR 3.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGACCATTTCCCCTGCTGACA	0.587000													26	75					0	0	1	0	0
DHRS2	10202	broad.mit.edu	37	14	24108096	24108096	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24108096G>C	ENST00000250383.6	+	2	499	c.23G>C	c.(22-24)gGc>gCc	p.G8A	DHRS2_ENST00000344777.7_Missense_Mutation_p.G8A|DHRS2_ENST00000553896.1_3'UTR	NM_005794.3	NP_005785.1	Q13268	DHRS2_HUMAN	dehydrogenase/reductase (SDR family) member 2	0					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00659)		GTTGCCCGGGGCTACCAGGGC	0.557000													38	86					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410142	159410142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159410142C>T	ENST00000423932.3	+	1	631	c.594C>T	c.(592-594)tcC>tcT	p.S198S	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	198					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TGAAGCTCTCCTGCATTGACA	0.438000													68	146					0	0	1	0	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238552	71238552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71238552C>T	ENST00000398536.4	+	1	240	c.206C>T	c.(205-207)tCc>tTc	p.S69F		NM_001012503.1	NP_001012521.1	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	69	7 X 4 AA repeats of C-C-X-P.					keratin filament				breast(1)|endometrium(1)|kidney(3)|lung(6)|ovary(1)	12						GGCTGTGGCTCCTGTGGGGGC	0.652000													57	254					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136570068	136570068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136570068G>A	ENST00000264162.2	-	7	2176	c.2166C>T	c.(2164-2166)tcC>tcT	p.S722S		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	722	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAATCCAAGAGGATGAGGTCT	0.522000													36	70					0	0	1	0	0
FBXO31	79791	broad.mit.edu	37	16	87377322	87377322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:87377322G>A	ENST00000311635.7	-	4	551	c.539C>T	c.(538-540)cCc>cTc	p.P180L		NM_024735.3	NP_079011.3	Q5XUX0	FBX31_HUMAN	F-box protein 31	180					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0272)		ATCGACGTGGGGGTCATGGGG	0.592000													10	62					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114537894	114537894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:114537894G>A	ENST00000371920.3	+	3	260	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K	LUZP4_ENST00000451986.2_Intron	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	85						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						CAACTCTGAGGAAGGAAATCA	0.343000													64	31					0	0	1	0	0
HDGFRP3	50810	broad.mit.edu	37	15	83808025	83808025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83808025G>A	ENST00000299633.4	-	6	1212	c.609C>T	c.(607-609)acC>acT	p.T203T		NM_016073.3	NP_057157.1	Q9Y3E1	HDGR3_HUMAN		203					cell proliferation	nucleus	growth factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						ATGGTAGTTAGGTCTGTAAAA	0.313000													11	104					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38040710	38040710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38040710C>T	ENST00000599616.1	+	6	493	c.493C>T	c.(493-495)Cgt>Tgt	p.R165C	Z83844.1_ENST00000456099.1_RNA|SH3BP1_ENST00000442465.2_Missense_Mutation_p.R229C|SH3BP1_ENST00000336738.5_Missense_Mutation_p.R229C|SH3BP1_ENST00000495174.1_3'UTR|SH3BP1_ENST00000357436.4_Missense_Mutation_p.R229C			Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	229	BAR.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					CTACTTCATTCGTGTGAGTCC	0.582000													49	214					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	6030491	6030491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6030491C>T	ENST00000356134.5	-	3	308	c.237G>A	c.(235-237)ttG>ttA	p.L79L	ANO2_ENST00000327087.8_Silent_p.L79L|ANO2_ENST00000546188.1_Silent_p.L79L	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	83						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GACGGGCCTCCAAGGACACAG	0.562000													10	44					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	90010762	90010762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:90010762G>A	ENST00000428670.3	-	12	2340	c.1884C>T	c.(1882-1884)gaC>gaT	p.D628D	ATP2B1_ENST00000261173.2_Silent_p.D628D|ATP2B1_ENST00000359142.3_Silent_p.D628D|ATP2B1_ENST00000393164.2_Silent_p.D371D|ATP2B1_ENST00000348959.3_Silent_p.D628D			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	628					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						TATCATCACGGTCCCTTGGTC	0.368000													17	106					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564036	176564036	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176564036C>T	ENST00000367662.3	+	3	2460	c.1296C>T	c.(1294-1296)gcC>gcT	p.A432A	PAPPA2_ENST00000367661.3_Silent_p.A432A	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	432					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGTCGACCGCCCTGCCACAAA	0.562000													29	83					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027865	55027865	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:55027865G>A	ENST00000371336.3	+	5	1834	c.1633G>A	c.(1633-1635)Gaa>Aaa	p.E545K	CASS4_ENST00000360314.3_Missense_Mutation_p.E545K|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	545					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						TTGGCCTCTGGAAGTTCTTGT	0.498000													23	54					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180372697	180372697	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:180372697C>T	ENST00000273654.4	-	13	1654	c.1035G>A	c.(1033-1035)ttG>ttA	p.L345L	CCDC39_ENST00000442201.2_Silent_p.L261L			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	261					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTTCTTTAACCAAATTTTCTT	0.284000													7	23					0	0	1	0	0
PMVK	10654	broad.mit.edu	37	1	154898850	154898850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154898850C>T	ENST00000368467.3	-	4	727	c.422G>A	c.(421-423)cGg>cAg	p.R141Q		NM_006556.3	NP_006547.1	Q15126	PMVK_HUMAN	phosphomevalonate kinase	141					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CACCCAGCCCCGCTGCTGTCG	0.632000													17	34					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796745	62796745	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62796745G>A	ENST00000582986.1	-	0	1175					NR_024386.1																						ACCTTCTGCAGGGCCTCCCGC	0.667000													10	43					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30703584	30703584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30703584C>T	ENST00000256246.2	-	1	3024	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	984										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAAGATGCTTCATCACTTAGG	0.348000													37	141					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40814611	40814611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40814611G>A	ENST00000396617.3	-	12	2421	c.1831C>T	c.(1831-1833)Cct>Tct	p.P611S	MKL1_ENST00000402042.1_Missense_Mutation_p.P561S|MKL1_ENST00000407029.1_Missense_Mutation_p.P611S|MKL1_ENST00000355630.3_Missense_Mutation_p.P611S			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	611	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						ACAGCACAAGGGTCTATGTGG	0.701000			T	RBM15	acute megakaryocytic leukemia								8	24					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117509617	117509617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:117509617C>T	ENST00000393203.2	+	6	1871	c.1724C>T	c.(1723-1725)tCc>tTc	p.S575F		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	575	Ig-like C2-type 5.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		AAAGTATCTTCCAAGAATATT	0.478000													12	56					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1258015	1258015	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1258015C>T	ENST00000348261.5	+	16	3405	c.3157C>T	c.(3157-3159)Ctg>Ttg	p.L1053L	CACNA1H_ENST00000565831.1_Silent_p.L1053L|CACNA1H_ENST00000358590.4_Silent_p.L1053L	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1053					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TCCCGCAGAGCTGAAGATGTG	0.667000													5	9					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849373	98849373	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:98849373G>A	ENST00000554295.1	-	0	1550					NR_033801.1																						AGAACACGATGAAAGGCGTGG	0.527000													5	11					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59853806	59853806	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59853806G>A	ENST00000259008.2	-	14	2320	c.2053C>T	c.(2053-2055)Cag>Tag	p.Q685*	BRIP1_ENST00000577598.1_Nonsense_Mutation_p.Q685*|BRIP1_ENST00000583837.1_5'UTR	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	685					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						CTCACAGTCTGGCACACAGAT	0.393000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					67	139					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55569084	55569084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55569084C>T	ENST00000395445.1	-	36	5120	c.4726G>A	c.(4726-4728)Gaa>Aaa	p.E1576K	PCDH15_ENST00000395446.1_Missense_Mutation_p.E772K|PCDH15_ENST00000395442.1_Missense_Mutation_p.E441K|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395440.1_Missense_Mutation_p.E510K|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000409834.1_3'UTR	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTATCTTCTTCCTCAAGGCGT	0.418000										HNSCC(58;0.16)			24	43					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9258912	9258912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9258912C>T	ENST00000318602.7	-	10	1331	c.1024G>A	c.(1024-1026)Gaa>Aaa	p.E342K		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	342					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	CTTGTGATTTCACTGGACTGC	0.408000													41	66					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55044969	55044969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55044969C>T	ENST00000335056.3	+	3	127	c.89C>T	c.(88-90)tCc>tTc	p.S30F																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GACAAGTTCTCCCTGTCAGCC	0.552000													7	74					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207173411	207173411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207173411G>A	ENST00000374423.3	+	5	4545	c.4159G>A	c.(4159-4161)Gaa>Aaa	p.E1387K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1387							nucleic acid binding|zinc ion binding	p.E1387K(2)		endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ACCTGTCAAAGAAATAAATCT	0.353000													21	35					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21086851	21086851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21086851C>T	ENST00000261383.3	-	21	3000	c.3001G>A	c.(3001-3003)Gaa>Aaa	p.E1001K	DNAH3_ENST00000415178.1_Missense_Mutation_p.E1001K	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1001	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGAGAGTATTCCTTGCTGGCA	0.463000													18	67					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039343	11039343	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039343C>T	ENST00000470054.1	-	0	860									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTTGATCTTCGCCACAAATA	0.383000													24	410					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95777493	95777493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95777493C>T	ENST00000414645.2	+	9	1052	c.953C>T	c.(952-954)tCt>tTt	p.S318F		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	318						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					TTGTTGGTATCTCCTTTATTA	0.289000													51	145					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134993876	134993876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:134993876C>T	ENST00000535938.1	+	18	2452	c.2285C>T	c.(2284-2286)tCt>tTt	p.S762F	SAGE1_ENST00000370709.3_Missense_Mutation_p.S762F|SAGE1_ENST00000537770.1_Missense_Mutation_p.S386F|SAGE1_ENST00000324447.3_Missense_Mutation_p.S762F	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	762										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					GCATTGGATTCTTTCTCTCAC	0.423000													61	96					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117311310	117311310	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:117311310C>T	ENST00000369478.3	+	5	1069	c.961C>T	c.(961-963)Cac>Tac	p.H321Y		NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	321	Pro-rich.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	CACACAAGTTCACCAGCAGAA	0.582000													62	163					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123984630	123984630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:123984630G>A	ENST00000306315.5	-	4	1882	c.1447C>T	c.(1447-1449)Cca>Tca	p.P483S	ZNF608_ENST00000504926.1_Missense_Mutation_p.P56S	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	483						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCACAATTTGGGGGTGTCCTT	0.562000													29	95					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38877379	38877379	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38877379G>A	ENST00000359357.3	+	63	9202	c.8948G>A	c.(8947-8949)aGg>aAg	p.R2983K	DNAH8_ENST00000449981.2_Missense_Mutation_p.R3200K|DNAH8_ENST00000441566.1_Missense_Mutation_p.R2947K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CGCTGGCCAAGGGAGGCTCTG	0.448000													11	117					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307705	140307705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140307705G>A	ENST00000253807.2	+	1	1228	c.1228G>A	c.(1228-1230)Gaa>Aaa	p.E410K	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.E410K|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGATCAGTGAATACCAAGT	0.527000													8	67					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3889576	3889576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3889576C>T	ENST00000520002.1	-	4	1016	c.461G>A	c.(460-462)gGa>gAa	p.G154E	CSMD1_ENST00000542608.1_Missense_Mutation_p.G154E|CSMD1_ENST00000539096.1_Missense_Mutation_p.G154E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G154E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G154E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G154E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G154E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	154	Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATGCAGAACTCCTTTCAGGAT	0.448000													16	45					0	0	1	0	0
ACTL7A	10881	broad.mit.edu	37	9	111625524	111625524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111625524G>A	ENST00000333999.3	+	1	922	c.922G>A	c.(922-924)Gag>Aag	p.E308K		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	308						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGATGGGAAGGAGATTCAGCT	0.542000													24	58					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634297	180634297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:180634297C>T	ENST00000410066.1	-	3	789	c.186G>A	c.(184-186)gtG>gtA	p.V62V		NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	62						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TCAGCTGCTTCACTCGTTTGC	0.597000													22	43					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110826853	110826853	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110826853C>T	ENST00000375820.4	-	39	3467	c.3346G>A	c.(3346-3348)Gaa>Aaa	p.E1116K		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1116	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TCACCTTTTTCTCCAGGTAGC	0.483000													20	39					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100623449	100623449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:100623449C>T	ENST00000317233.4	-	6	753	c.518G>A	c.(517-519)gGa>gAa	p.G173E	AFF3_ENST00000409236.1_Missense_Mutation_p.G173E|AFF3_ENST00000409579.1_Missense_Mutation_p.G198E|AFF3_ENST00000356421.2_Missense_Mutation_p.G198E	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	173					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						AACACCATCTCCAAGCAAGGT	0.547000													17	45					0	0	1	0	0
CYP2A7	1549	broad.mit.edu	37	19	41386449	41386449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41386449C>T	ENST00000301146.4	-	3	969	c.428G>A	c.(427-429)cGa>cAa	p.R143Q	CTC-490E21.12_ENST00000601627.1_Intron|CYP2A7_ENST00000291764.3_Missense_Mutation_p.R92Q	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	143						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CTCGATGCCTCGCTTGCCCAC	0.672000													11	32					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27167606	27167606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27167606G>A	ENST00000288699.6	+	12	1681	c.1523G>A	c.(1522-1524)gGa>gAa	p.G508E	DPYSL5_ENST00000401478.1_Missense_Mutation_p.G508E	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	508					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAAGAGATGGGAACCCCACTC	0.582000													31	95					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111595608	111595608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:111595608C>T	ENST00000261486.5	-	8	987	c.711G>A	c.(709-711)aaG>aaA	p.K237K		NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	237	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TCCCCACTTGCTTTTTATTCT	0.408000													30	83					0	0	1	0	0
GJB4	127534	broad.mit.edu	37	1	35227159	35227159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35227159G>A	ENST00000339480.1	+	2	674	c.304G>A	c.(304-306)Gag>Aag	p.E102K	RP1-34M23.5_ENST00000542839.1_RNA	NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	102					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CGAGGAACGCGAGCGCAAGCA	0.647000													13	22					0	0	1	0	0
MED14	9282	broad.mit.edu	37	X	40551483	40551483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:40551483G>A	ENST00000324817.1	-	15	2050	c.1932C>T	c.(1930-1932)ttC>ttT	p.F644F		NM_004229.3	NP_004220.2	O60244	MED14_HUMAN	mediator complex subunit 14	644	Interaction with SREBF1.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(2)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ACATAGCGACGAAGTGGGCTA	0.378000													28	13					0	0	1	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7509157	7509157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7509157C>T	ENST00000593531.1	+	7	737	c.737C>T	c.(736-738)cCc>cTc	p.P246L	ARHGEF18_ENST00000319670.9_Silent_p.A130A|ARHGEF18_ENST00000359920.6_Silent_p.A288A																							ACTCCAGGGCCCTGCAGGAGG	0.617000													19	51					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79399020	79399020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79399020G>A	ENST00000264895.6	+	55	8343	c.7903G>A	c.(7903-7905)Gat>Aat	p.D2635N		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2630	Calx-beta 1.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGTCATCAACGATGATGACGT	0.483000													9	17					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123515039	123515039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:123515039C>T	ENST00000422452.2	-	32	7609	c.7546G>A	c.(7546-7548)Gga>Aga	p.G2516R	TENM1_ENST00000371130.3_Missense_Mutation_p.G2509R|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TGCTTCCCTCCTTCAAGGCAC	0.453000													74	50					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359609	66359609	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66359609G>A	ENST00000333861.3	-	1	945	c.878C>T	c.(877-879)cCc>cTc	p.P293L		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	293										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CCTGCTGGTGGGGGCCACAGG	0.602000													35	73					0	0	1	0	0
HFE2	148738	broad.mit.edu	37	1	145416700	145416700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145416700G>A	ENST00000336751.5	+	4	1283	c.1045G>A	c.(1045-1047)Gaa>Aaa	p.E349K	HFE2_ENST00000357836.5_Missense_Mutation_p.E236K|HFE2_ENST00000497365.1_Missense_Mutation_p.E123K|HFE2_ENST00000475797.1_Missense_Mutation_p.E123K	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	349					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCTGTGCAAGGAAGGGCTTCC	0.527000													16	47					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16955966	16955966	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:16955966A>T	ENST00000377833.4	-	48	7442	c.7377T>A	c.(7375-7377)tcT>tcA	p.S2459S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2459	CUB 18.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGTTCCAATAGAGCCCTGAA	0.478000													31	75					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179582436	179582436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179582436G>A	ENST00000589042.1	-	87	25389	c.25165C>T	c.(25165-25167)Ctt>Ttt	p.L8389F	TTN_ENST00000342992.6_Missense_Mutation_p.L7145F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.L8072F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8072	Ig-like 66.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACACTTGAAGAGGTTCTGAG	0.408000													4	27					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152737379	152737379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152737379C>T	ENST00000360283.6	-	3	480	c.223G>A	c.(223-225)Gag>Aag	p.E75K	CACNB4_ENST00000201943.5_Missense_Mutation_p.E109K|CACNB4_ENST00000539935.1_Missense_Mutation_p.E109K|CACNB4_ENST00000427385.1_Missense_Mutation_p.E91K|CACNB4_ENST00000534999.1_Missense_Mutation_p.E75K|CACNB4_ENST00000397327.2_Missense_Mutation_p.E62K			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	109					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GGCACATCCTCGTCCAGGGCG	0.473000													13	26					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952418	119952418	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119952418G>A	ENST00000307142.4	+	4	2684	c.2488G>A	c.(2488-2490)Gga>Aga	p.G830R	SYNPO2_ENST00000434046.2_Missense_Mutation_p.G830R|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Missense_Mutation_p.G830R	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	830						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TCCCTTCAAAGGACCACAAGC	0.532000													21	51					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81599243	81599243	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:81599243C>T	ENST00000356860.3	-	28	2600	c.2262G>A	c.(2260-2262)agG>agA	p.R754R	CACNA2D1_ENST00000535308.1_Intron|CACNA2D1_ENST00000356253.5_Silent_p.R766R	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	766						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TATCTAGGCTCCTTTTATAGA	0.338000													21	81					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1247914	1247914	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1247914G>A	ENST00000447027.1	+	4	327	c.269G>A	c.(268-270)gGc>gAc	p.G90D	MUC5B_ENST00000529681.1_Missense_Mutation_p.G90D			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	90	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACCTTCGACGGCGACGTCTTC	0.647000													7	25					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97078893	97078893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:97078893C>T	ENST00000524981.3	+	9	1244	c.1244C>T	c.(1243-1245)tCa>tTa	p.S415L				Q6ZTY8	CL063_HUMAN		389										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						TTTGGCCCCTCACTCACCAAT	0.468000													16	40					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005313	74005313	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74005313C>T	ENST00000301607.3	-	22	4226	c.3973G>A	c.(3973-3975)Gtg>Atg	p.V1325M	EVPL_ENST00000586740.1_Missense_Mutation_p.V1347M	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1325	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						TTCTCCAGCACCGGGTCCTTC	0.697000													18	264					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121957514	121957514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121957514C>T	ENST00000379692.4	-	4	2138	c.1612G>A	c.(1612-1614)Ggc>Agc	p.G538S		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	538	Fibronectin type-III 2.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						TAAGATTTGCCAGGCTGAAGA	0.403000													49	116					0	0	1	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490495	141490495	+	Missense_Mutation	SNP	C	C	T	rs146440743		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141490495C>T	ENST00000247883.4	+	1	479	c.334C>T	c.(334-336)Cgc>Tgc	p.R112C		NM_018980.2	NP_061853.1	Q9NYW4	TA2R5_HUMAN	taste receptor, type 2, member 5	112					chemosensory behavior|sensory perception of taste		taste receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9	Melanoma(164;0.0171)					GACCTTCGATCGCCCGGCCTA	0.483000													7	87					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757435	8757435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8757435G>A	ENST00000229335.6	-	4	614	c.511C>T	c.(511-513)Cgt>Tgt	p.R171C	AICDA_ENST00000537228.1_Missense_Mutation_p.R161C	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	171					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					CTGGAGAGACGAACTGAATTT	0.368000													36	160					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2595295	2595295	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2595295C>T	ENST00000399655.1	+	6	1048	c.783C>T	c.(781-783)atC>atT	p.I261I	CACNA1C_ENST00000399637.1_Silent_p.I261I|CACNA1C_ENST00000480911.1_Silent_p.I261I|CACNA1C_ENST00000335762.5_Silent_p.I261I|CACNA1C_ENST00000399603.1_Silent_p.I261I|CACNA1C_ENST00000399649.1_Silent_p.I261I|CACNA1C_ENST00000399595.1_Silent_p.I261I|CACNA1C_ENST00000399606.1_Silent_p.I261I|CACNA1C_ENST00000399601.1_Silent_p.I261I|CACNA1C_ENST00000399617.1_Silent_p.I261I|CACNA1C_ENST00000344100.3_Silent_p.I261I|CACNA1C_ENST00000399621.1_Silent_p.I261I|CACNA1C_ENST00000399629.1_Silent_p.I261I|CACNA1C_ENST00000327702.7_Silent_p.I261I|CACNA1C_ENST00000406454.3_Silent_p.I261I|CACNA1C_ENST00000402845.3_Silent_p.I261I|CACNA1C_ENST00000399597.1_Silent_p.I261I|CACNA1C_ENST00000347598.4_Silent_p.I261I|CACNA1C_ENST00000399641.1_Silent_p.I261I|CACNA1C_ENST00000399638.1_Silent_p.I261I|CACNA1C_ENST00000399644.1_Silent_p.I261I|CACNA1C_ENST00000399591.1_Silent_p.I261I|CACNA1C_ENST00000399634.1_Silent_p.I261I	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	261					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGAATTCCATCATCAAGGCCA	0.562000													4	24					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15760766	15760766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15760766C>T	ENST00000221307.7	+	7	739	c.691C>T	c.(691-693)Ctt>Ttt	p.L231F	CYP4F3_ENST00000591058.1_Missense_Mutation_p.L231F|CYP4F3_ENST00000585846.1_Missense_Mutation_p.L231F|CYP4F3_ENST00000586182.1_Missense_Mutation_p.L231F	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	231					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GCTCAGTGCCCTTGTGACAAA	0.527000													76	154					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73063711	73063711	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73063711G>A	ENST00000429829.1	-	0	8877					NR_001564.2																						GTACTACAAAGGAAAGGTGAT	0.403000													12	3					0	0	1	0	0
TRAV10	28676	broad.mit.edu	37	14	22294096	22294096	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22294096C>T	ENST00000390432.2	+	0	236																											GGTCCTGTTTCCCTGACAATC	0.458000													54	100					0	0	1	0	0
SDHAF2	54949	broad.mit.edu	37	11	61213508	61213508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61213508C>T	ENST00000301761.2	+	4	540	c.466C>T	c.(466-468)Cca>Tca	p.P156S	SDHAF2_ENST00000537782.1_3'UTR|RP11-286N22.8_ENST00000543044.1_Missense_Mutation_p.P144S|SDHAF2_ENST00000543265.1_3'UTR|SDHAF2_ENST00000542074.1_3'UTR|RP11-286N22.8_ENST00000544880.1_Intron	NM_017841.2	NP_060311.1	Q9NX18	SDHF2_HUMAN	succinate dehydrogenase complex assembly factor 2	156					mitochondrial electron transport, succinate to ubiquinone|protein-FAD linkage	mitochondrion	protein binding			large_intestine(3)|lung(4)|ovary(2)	9						ACTGCGTGCCCCAGATCTTGA	0.473000											OREG0021000	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	91					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95335847	95335847	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95335847G>A	ENST00000371483.4	+	2	623		c.e2-1		FFAR4_ENST00000604414.1_Splice_Site|FFAR4_ENST00000371481.4_Splice_Site	NM_181745.3	NP_859529.2			free fatty acid receptor 4									p.?(1)									TTTGTAACTAGGAAATTTCGA	0.438000													42	94					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88241775	88241775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88241775G>A	ENST00000418177.2	-	10	3991	c.3624C>T	c.(3622-3624)agC>agT	p.S1208S	GRM5_ENST00000305447.4_Silent_p.S1208S|GRM5_ENST00000393297.1_Silent_p.S938S|GRM5-AS1_ENST00000526448.1_RNA|GRM5_ENST00000455756.2_Silent_p.S1176S|GRM5_ENST00000305432.5_Silent_p.S1176S			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	1208					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ACGACGAGGAGCTCTGAGTGT	0.587000													16	42					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35387967	35387967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35387967C>T	ENST00000311565.4	+	5	543	c.194C>T	c.(193-195)gCc>gTc	p.A65V	PPARD_ENST00000337400.2_Missense_Mutation_p.A65V|PPARD_ENST00000418635.2_Intron|PPARD_ENST00000444397.1_Missense_Mutation_p.A65V|PPARD_ENST00000448077.2_Missense_Mutation_p.A26V|PPARD_ENST00000540939.1_Intron|PPARD_ENST00000360694.3_Missense_Mutation_p.A65V	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	65					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	TGTGACGGGGCCTCATGCGGC	0.637000													19	43					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111540084	111540084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:111540084G>A	ENST00000261486.5	-	15	1640	c.1364C>T	c.(1363-1365)cCt>cTt	p.P455L	CTC-459M5.2_ENST00000506875.1_RNA|EPB41L4A_ENST00000507810.1_5'UTR	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	455						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		CCTCCTCACAGGCTGTACAGA	0.483000													57	131					0	0	1	0	0
ESM1	11082	broad.mit.edu	37	5	54277898	54277898	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54277898C>T	ENST00000381405.4	-	2	523	c.378G>A	c.(376-378)acG>acA	p.T126T	ESM1_ENST00000381403.4_Intron|ESM1_ENST00000598310.1_Intron	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	126					angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			GGCATTTTCCCGTCCCCCTGT	0.493000													49	107					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74607058	74607058	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74607058A>G	ENST00000253159.8	+	10	1699	c.1501A>G	c.(1501-1503)Atc>Gtc	p.I501V	ZNF236_ENST00000320610.9_Missense_Mutation_p.I503V	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	501					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GGTCCGCCACATCCGCATCCA	0.647000													44	130					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149497196	149497196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149497196G>A	ENST00000261799.4	-	22	3591	c.3122C>T	c.(3121-3123)tCc>tTc	p.S1041F		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	1041					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TAGGCTGGGGGAACCCTCCAG	0.612000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								18	55					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183714469	183714469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183714469G>A	ENST00000511685.1	+	26	6767	c.6644G>A	c.(6643-6645)cGa>cAa	p.R2215Q	TENM3_ENST00000406950.2_Missense_Mutation_p.R2215Q					teneurin transmembrane protein 3																		CTTCTAACTCGAGTTTACAGT	0.483000													23	51					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137707461	137707461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137707461G>A	ENST00000371817.3	+	51	4468	c.4054G>A	c.(4054-4056)Gag>Aag	p.E1352K		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1352	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCCCCCGGAGAGCCTGGCCC	0.622000													5	23					0	0	1	0	0
CACNB4	785	broad.mit.edu	37	2	152737408	152737408	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152737408G>T	ENST00000360283.6	-	3	451	c.194C>A	c.(193-195)aCa>aAa	p.T65K	CACNB4_ENST00000201943.5_Missense_Mutation_p.T99K|CACNB4_ENST00000539935.1_Missense_Mutation_p.T99K|CACNB4_ENST00000427385.1_Missense_Mutation_p.T81K|CACNB4_ENST00000534999.1_Missense_Mutation_p.T65K|CACNB4_ENST00000397327.2_Missense_Mutation_p.T52K			O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4 subunit	99					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	GCTCACATTTGTCTTCACGGC	0.448000													14	31					4.7546e-09	4.77245e-09	1	1	0
CTBP2	1488	broad.mit.edu	37	10	126715662	126715662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:126715662G>A	ENST00000309035.6	-	1	797	c.667C>T	c.(667-669)Cct>Tct	p.P223S	CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000411419.2_Intron|CTBP2_ENST00000337195.5_Intron|CTBP2_ENST00000494626.2_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		TGTCTGGCAGGGGCAGGGTCA	0.677000													27	75					0	0	1	0	0
TAS2R14	50840	broad.mit.edu	37	12	11091012	11091012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11091012G>A	ENST00000537503.1	-	1	850	c.795C>T	c.(793-795)tcC>tcT	p.S265S	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_5'UTR	NM_023922.1	NP_076411.1	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	265					detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	8						CCATCACCTGGGAAAGAATAA	0.423000													11	124					0	0	1	0	0
CCBL1	883	broad.mit.edu	37	9	131600089	131600089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131600089G>A	ENST00000436267.2	-	8	873	c.724C>T	c.(724-726)Ccc>Tcc	p.P242S	CCBL1_ENST00000483599.1_5'UTR|CCBL1_ENST00000320665.6_Missense_Mutation_p.P98S|CCBL1_ENST00000302586.3_Missense_Mutation_p.P148S			Q16773	KAT1_HUMAN	cysteine conjugate-beta lyase, cytoplasmic	148					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	TTCTGGATGGGACCCTGCAAG	0.582000													5	61					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664043	44664043	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44664043G>A	ENST00000454036.1	+	3	293	c.216_splice	c.e3-1	p.E73_splice	SLC12A5_ENST00000539566.1_Splice_Site_p.E50_splice|SLC12A5_ENST00000372315.1_Splice_Site_p.E50_splice|SLC12A5_ENST00000243964.3_Splice_Site_p.E50_splice	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	73					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCCTCCATAGGAGGAGATGGA	0.592000													29	262					0	0	1	0	0
OR1B1	347169	broad.mit.edu	37	9	125391169	125391169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125391169G>A	ENST00000304833.3	-	1	683	c.646C>T	c.(646-648)Ccc>Tcc	p.P216S	RP11-64P14.7_ENST00000419604.1_RNA|RP11-64P14.7_ENST00000431442.1_RNA	NM_001004450.1	NP_001004450.1	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B, member 1	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)	16						AGGGCACAGGGGCCCAGCATA	0.537000													8	62					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242078	60242078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:60242078C>T	ENST00000269499.5	+	13	3182	c.2764C>T	c.(2764-2766)Ccc>Tcc	p.P922S	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.P601S	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	922					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						ACCAGGCTCTCCCCTTGCTGC	0.617000													24	49					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46474037	46474037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46474037C>T	ENST00000361297.2	+	9	1255	c.972C>T	c.(970-972)ttC>ttT	p.F324F	MAST2_ENST00000372008.1_Silent_p.F209F|MAST2_ENST00000372009.2_Silent_p.F324F	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	324					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					AAGAAAGATTCCCAAAGGTAA	0.428000													11	41					0	0	1	0	0
C9orf47	286223	broad.mit.edu	37	9	91606031	91606031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91606031C>T	ENST00000375851.2	+	1	254	c.121C>T	c.(121-123)Cca>Tca	p.P41S	C9orf47_ENST00000375850.3_Missense_Mutation_p.P41S|C9orf47_ENST00000334490.5_Missense_Mutation_p.P41S	NM_001001938.3|NM_001142413.1	NP_001001938.1|NP_001135885.1	Q6ZRZ4	CI047_HUMAN	chromosome 9 open reading frame 47	41						extracellular region				endometrium(1)|large_intestine(1)|liver(1)|lung(1)	4						GGACCTGGTTCCAAGCCTGTT	0.612000													13	22					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100609643	100609643	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100609643T>G	ENST00000319509.7	+	8	2375	c.2375T>G	c.(2374-2376)gTg>gGg	p.V792G	RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GCGCTGCTGGTGCTGCTGCTG	0.791000													3	2					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150868557	150868557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150868557G>A	ENST00000370353.3	+	3	487	c.97G>A	c.(97-99)Gag>Aag	p.E33K	PRRG3_ENST00000370354.1_Missense_Mutation_p.E41K|PRRG3_ENST00000538575.1_Missense_Mutation_p.E33K			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	33	Gla.					extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					GGGCACCATCGAGCGAGAGTG	0.562000													26	20					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32036794	32036794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32036794C>T	ENST00000375244.3	-	16	5908	c.5707G>A	c.(5707-5709)Gtg>Atg	p.V1903M	TNXB_ENST00000375247.2_Missense_Mutation_p.V1903M			P22105	TENX_HUMAN	tenascin XB	1985	Fibronectin type-III 11.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCCTCAGTCACCATCCAGGAG	0.582000													45	93					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1562025	1562025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:1562025G>A	ENST00000572621.1	-	32	5436	c.5171C>T	c.(5170-5172)cCt>cTt	p.P1724L	PRPF8_ENST00000304992.6_Missense_Mutation_p.P1724L			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1724	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TTGTATGAGAGGCTTGCTGCC	0.498000													25	26					0	0	1	0	0
FAM73B	84895	broad.mit.edu	37	9	131804628	131804628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131804628C>T	ENST00000277475.5	+	3	328	c.142C>T	c.(142-144)Ctc>Ttc	p.L48F	FAM73B_ENST00000358369.4_Missense_Mutation_p.L48F|FAM73B_ENST00000406926.2_Missense_Mutation_p.L48F|FAM73B_ENST00000474534.1_3'UTR			Q7L4E1	FA73B_HUMAN	family with sequence similarity 73, member B	48						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)	13						GCGGAAAGTCCTCTTTGCCAC	0.647000													11	35					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52425320	52425320	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52425320C>T	ENST00000420323.2	+	62	10128	c.9867C>T	c.(9865-9867)gcC>gcT	p.A3289A		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3354	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TAGACCCAGCCCTGGAGCCAG	0.627000													6	15					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39159259	39159259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39159259C>T	ENST00000359534.3	-	5	1245	c.907G>A	c.(907-909)Gac>Aac	p.D303N		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	303					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity	p.D303Y(1)|p.D303N(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						TTGATGAGGTCGTTGTAGGTC	0.627000													60	190					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22312906	22312906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22312906G>A	ENST00000398793.2	-	17	2499	c.2065C>T	c.(2065-2067)Ccc>Tcc	p.P689S	TOP3B_ENST00000357179.5_Missense_Mutation_p.P689S	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	689					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TAGCAGTAGGGGCACAGCGGG	0.587000													25	98					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32151349	32151349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32151349G>A	ENST00000373672.3	-	29	2423	c.1907C>T	c.(1906-1908)cCa>cTa	p.P636L	COL16A1_ENST00000373668.3_Missense_Mutation_p.P636L|COL16A1_ENST00000271069.6_Missense_Mutation_p.P635L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	636	Nonhelical region 7 (NC7).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGACAGGGCTGGGCACGGCTC	0.637000													50	201					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133654618	133654618	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133654618C>T	ENST00000310926.4	-	13	2087	c.1814_splice	c.e13+1	p.R605_splice	SLCO2A1_ENST00000493729.1_Splice_Site_p.R529_splice	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	605					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GGGCCCTCACCTGTCTCGGAG	0.597000													19	35					0	0	1	0	0
PTH	5741	broad.mit.edu	37	11	13514323	13514323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:13514323G>A	ENST00000282091.1	-	2	194	c.80C>T	c.(79-81)tCt>tTt	p.S27F	PTH_ENST00000529816.1_Missense_Mutation_p.S27F	NM_000315.2	NP_000306.1	P01270	PTHY_HUMAN	parathyroid hormone	27					bone resorption|cAMP metabolic process|cell-cell signaling|cellular calcium ion homeostasis|cellular macromolecule biosynthetic process|induction of apoptosis by hormones|positive regulation of cAMP biosynthetic process|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|skeletal system development		hormone activity|peptide hormone receptor binding			endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(625;0.00116)|Epithelial(150;0.0357)|LUSC - Lung squamous cell carcinoma(625;0.0836)		TTACTTAACAGATTTCCCATC	0.373000													9	31					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60241837	60241837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:60241837C>T	ENST00000269499.5	+	13	2941	c.2523C>T	c.(2521-2523)atC>atT	p.I841I	ZCCHC2_ENST00000586834.1_Silent_p.I520I	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	841					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						GCCTGAGCATCGCATCACCAA	0.507000													26	90					0	0	1	0	0
SPINT4	391253	broad.mit.edu	37	20	44352646	44352646	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44352646C>T	ENST00000279058.3	+	2	260	c.243C>T	c.(241-243)ttC>ttT	p.F81F		NM_178455.1	NP_848550.1	Q6UDR6	SPIT4_HUMAN	serine peptidase inhibitor, Kunitz type 4	81	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			lung(6)|ovary(1)|skin(1)	8		Myeloproliferative disorder(115;0.028)				TTAACAACTTCAAGCTTAAAA	0.403000													24	118					0	0	1	0	0
CAPN7	23473	broad.mit.edu	37	3	15265021	15265021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:15265021C>T	ENST00000253693.2	+	6	931	c.678C>T	c.(676-678)ttC>ttT	p.F226F		NM_014296.2	NP_055111.1	Q9Y6W3	CAN7_HUMAN	calpain 7	226					proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						ATGTTCCTTTCATGAATGTTG	0.318000													29	105					0	0	1	0	0
B3GNT6	192134	broad.mit.edu	37	11	76751273	76751273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76751273C>T	ENST00000533140.1	+	2	816	c.678C>T	c.(676-678)ttC>ttT	p.F226F	B3GNT6_ENST00000421061.1_Silent_p.F137F|B3GNT6_ENST00000354301.5_Silent_p.F226F			Q6ZMB0	B3GN6_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)	226					O-glycan processing, core 3	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)|kidney(2)|lung(4)|prostate(1)	8						ACGACGTGTTCGTGCACACCG	0.677000													7	41					0	0	1	0	0
TMEM156	80008	broad.mit.edu	37	4	39000465	39000465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39000465G>A	ENST00000381938.3	-	2	260	c.153C>T	c.(151-153)tcC>tcT	p.S51S	TMEM156_ENST00000372489.2_5'UTR	NM_024943.1	NP_079219.1	Q8N614	TM156_HUMAN	transmembrane protein 156	51						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						AATTTAAGGAGGAGAGTGAAT	0.333000													19	36					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121981045	121981045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121981045C>T	ENST00000498619.1	+	4	1601	c.1163C>T	c.(1162-1164)tCg>tTg	p.S388L	CASR_ENST00000296154.5_Missense_Mutation_p.S388L|CASR_ENST00000490131.1_Missense_Mutation_p.S388L	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	388					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGCAACAGCTCGACAGCCTTC	0.488000													9	60					0	0	1	0	0
USP30	84749	broad.mit.edu	37	12	109509423	109509423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109509423C>T	ENST00000257548.5	+	5	580	c.487C>T	c.(487-489)Cac>Tac	p.H163Y	USP30_ENST00000392784.2_Missense_Mutation_p.H132Y	NM_032663.3	NP_116052.2	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	163					ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			endometrium(7)|kidney(1)|large_intestine(1)|liver(2)|lung(11)|prostate(1)|skin(3)|stomach(2)	28						ACAGGATGCTCACGAATTATT	0.493000													23	39					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35544969	35544969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35544969C>T	ENST00000536438.1	-	11	1383	c.1068G>A	c.(1066-1068)agG>agA	p.R356R	FKBP5_ENST00000357266.4_Silent_p.R356R|FKBP5_ENST00000540787.1_Silent_p.R177R|FKBP5_ENST00000539068.1_Silent_p.R356R	NM_001145775.1	NP_001139247.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	356					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						CTTCACCCCTCCTATACAAGC	0.453000													17	223					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167489245	167489245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167489245G>A	ENST00000519204.1	+	6	1245	c.1127G>A	c.(1126-1128)aGa>aAa	p.R376K	TENM2_ENST00000403607.2_Missense_Mutation_p.R330K|TENM2_ENST00000545108.1_Missense_Mutation_p.R497K|TENM2_ENST00000518659.1_Missense_Mutation_p.R497K|TENM2_ENST00000520394.1_Missense_Mutation_p.R265K					teneurin transmembrane protein 2																		TACATAAGAAGAGGACTTCCA	0.408000													36	82					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120009333	120009333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:120009333C>T	ENST00000371311.3	-	1	446	c.192G>A	c.(190-192)gaG>gaA	p.E64E		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	64										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						GCTCACCCTCCTCCTCCCCGA	0.731000													30	41					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41621801	41621801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41621801C>T	ENST00000216237.5	+	12	1518	c.1360C>T	c.(1360-1362)Ctc>Ttc	p.L454F		NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	454					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCCCCAGGTTCTCCTGGATGG	0.592000													16	44					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6181520	6181520	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6181520G>A	ENST00000261405.5	-	9	1340	c.1086C>T	c.(1084-1086)tcC>tcT	p.S362S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	362					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CTCGAGAGAGGGAGGTGCCGG	0.657000													20	44					0	0	1	0	0
TRIM50	135892	broad.mit.edu	37	7	72738612	72738612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72738612C>T	ENST00000333149.2	-	2	374	c.174G>A	c.(172-174)caG>caA	p.Q58Q	TRIM50_ENST00000493498.1_5'UTR|TRIM50_ENST00000453152.1_Silent_p.Q58Q	NM_178125.2	NP_835226.1	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	58						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						CGTCCACCGCCTGCCGGCACA	0.687000											OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	57					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87092147	87092147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87092147G>A	ENST00000265723.4	-	4	324	c.213C>T	c.(211-213)ctC>ctT	p.L71L	ABCB4_ENST00000358400.3_Silent_p.L71L|ABCB4_ENST00000545634.1_Silent_p.L71L|ABCB4_ENST00000359206.3_Silent_p.L71L|ABCB4_ENST00000453593.1_Silent_p.L71L	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	71	ABC transmembrane type-1 1.			IMAIAHGSGLP -> RGSSRVDLQAC (in Ref. 5; CAA84542).	cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TCATGAGGGGGAGACCTGATC	0.378000													18	60					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43269342	43269342	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43269342G>A	ENST00000372585.5	+	7	1068	c.973G>A	c.(973-975)Ggg>Agg	p.G325R	SLC22A7_ENST00000372589.3_Missense_Mutation_p.G323R|SLC22A7_ENST00000372574.3_Missense_Mutation_p.G323R|SLC22A7_ENST00000487175.1_3'UTR	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	325						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity	p.G325W(2)		NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			AGTGGCCGCCGGGGAACGGGT	0.587000													19	35					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2979523	2979523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2979523C>T	ENST00000396946.4	-	6	1127	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	242					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		AGCTTACATTCCTCCTCCATC	0.478000			Mis		DLBCL								32	124					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042352	75042352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75042352G>A	ENST00000343932.4	+	2	336	c.273G>A	c.(271-273)ctG>ctA	p.L91L		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	91					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TGAGCCGCCTGGACACCATCC	0.652000													14	85					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155156135	155156135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155156135G>A	ENST00000357232.3	-	25	8303	c.8304C>T	c.(8302-8304)acC>acT	p.T2768T		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2768					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CATGATCAGAGGTCGTCTGAG	0.418000													45	98					0	0	1	0	0
AGR2	10551	broad.mit.edu	37	7	16839434	16839434	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:16839434C>T	ENST00000419304.2	-	5	416	c.264G>A	c.(262-264)aaG>aaA	p.K88K	AGR2_ENST00000401412.1_Silent_p.K88K|AGR2_ENST00000419572.2_Silent_p.K108K	NM_006408.3	NP_006399.1	O95994	AGR2_HUMAN	anterior gradient 2	88					mucus secretion	endoplasmic reticulum|extracellular region	protein binding			endometrium(2)|lung(1)|prostate(1)|skin(2)	6	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		CAAACACTTTCTTTAAAGCTA	0.289000													5	47					0	0	1	0	0
QTRT1	81890	broad.mit.edu	37	19	10823277	10823277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10823277C>T	ENST00000250237.5	+	7	844	c.834C>T	c.(832-834)ttC>ttT	p.F278F		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	278					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GTGACATGTTCGACTGCGTCT	0.637000													65	166					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434244	72434244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:72434244C>T	ENST00000373517.3	-	1	440	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	NAP1L2_ENST00000536638.1_Intron	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	29					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TCCAGATGTTCCCCGAGCCCT	0.562000													26	21					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206225182	206225182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206225182G>A	ENST00000367126.4	+	1	1207	c.742G>A	c.(742-744)Gac>Aac	p.D248N		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	248					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	GAGGACTTGGGACAGGCCCTC	0.592000													35	84					0	0	1	0	0
C8orf86	389649	broad.mit.edu	37	8	38370017	38370017	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:38370017C>T	ENST00000437935.2	-	2	406	c.387G>A	c.(385-387)tgG>tgA	p.W129*	C8orf86_ENST00000358138.1_Missense_Mutation_p.G187E			Q6ZUL3	CH086_HUMAN	chromosome 8 open reading frame 86	0								p.G187E(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						atgtgcatttccaatcagttc	0.532000													34	85					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16355714	16355714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16355714G>A	ENST00000375692.1	+	13	1275	c.1147G>A	c.(1147-1149)Gac>Aac	p.D383N	CLCNKA_ENST00000420078.1_Missense_Mutation_p.D383N|CLCNKA_ENST00000439316.2_Missense_Mutation_p.D340N|CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000331433.4_Missense_Mutation_p.D383N			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	383					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CGAGGAGCTCGACCCCCAGCA	0.622000													28	68					0	0	1	0	0
OR52A1	23538	broad.mit.edu	37	11	5172952	5172952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5172952G>A	ENST00000380367.1	-	2	1065	c.648C>T	c.(646-648)ttC>ttT	p.F216F	OR52A1_ENST00000328942.1_Silent_p.F216F			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	216					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACAATGTGATGAATGTGAGGT	0.413000													48	99					0	0	1	0	0
TAPBP	6892	broad.mit.edu	37	6	33281164	33281164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33281164G>A	ENST00000434618.2	-	3	644	c.299C>T	c.(298-300)cCc>cTc	p.P100L	TAPBP_ENST00000456592.2_Missense_Mutation_p.P100L|TAPBP_ENST00000475304.1_Missense_Mutation_p.P100L|TAPBP_ENST00000426633.2_Missense_Mutation_p.P100L|TAPBP_ENST00000489157.1_Intron	NM_003190.4|NM_172209.2	NP_003181.3|NP_757346.2	O15533	TPSN_HUMAN	TAP binding protein (tapasin)	100					antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			endometrium(2)|large_intestine(5)|lung(8)|ovary(3)	18						CGCAGAGGCGGGGAGAGGCAC	0.706000													4	31					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	994600	994600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:994600C>T	ENST00000537687.1	+	19	6053	c.5410C>T	c.(5410-5412)Ctc>Ttc	p.L1804F	WNK1_ENST00000535572.1_Missense_Mutation_p.L1297F|WNK1_ENST00000315939.6_Missense_Mutation_p.L1544F|WNK1_ENST00000530271.2_Missense_Mutation_p.L2042F|WNK1_ENST00000340908.4_Missense_Mutation_p.L1137F	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1544					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity	p.L1544I(1)|p.L1804I(1)		breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GGCTTTCTCCCTCTCTGCACC	0.478000													101	395					0	0	1	0	0
NPPA	4878	broad.mit.edu	37	1	11907193	11907193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11907193C>T	ENST00000376480.3	-	2	525	c.427G>A	c.(427-429)Gga>Aga	p.G143R	NPPA-AS1_ENST00000446542.1_RNA|NPPA_ENST00000376476.1_Missense_Mutation_p.G93R|NPPA-AS1_ENST00000400892.2_RNA	NM_006172.3	NP_006163.1	P01160	ANF_HUMAN	natriuretic peptide A	143					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCCCAGTCCGCTCTGGGCT	0.597000													128	304					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53558288	53558288	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:53558288G>A	ENST00000025008.5	-	16	4484	c.3961C>T	c.(3961-3963)Cga>Tga	p.R1321*	RB1CC1_ENST00000435644.2_Nonsense_Mutation_p.R1321*|RB1CC1_ENST00000539297.1_Nonsense_Mutation_p.R1321*|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1321					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AAAGATGTTCGAACATTTTGC	0.313000													18	44					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11053475	11053475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11053475C>T	ENST00000295082.1	+	1	1413	c.923C>T	c.(922-924)tCg>tTg	p.S308L		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	308						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CGCCACTCCTCGGGCCTGCAG	0.637000													6	23					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35802512	35802512	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35802512C>T	ENST00000342694.2	+	11	1978	c.1723C>T	c.(1723-1725)Cag>Tag	p.Q575*		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	575	Protein kinase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	GAGAGATGTTCAGTTCAACCA	0.413000													7	61					0	0	1	0	0
CDT1	81620	broad.mit.edu	37	16	88873061	88873061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:88873061C>T	ENST00000301019.4	+	7	1720	c.1101C>T	c.(1099-1101)gcC>gcT	p.A367A		NM_030928.3	NP_112190.2	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor 1	367					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(80;0.0476)		TGGCCCGGGCCCGCAACCTGA	0.667000													5	17					0	0	1	0	0
TMEM74B	55321	broad.mit.edu	37	20	1162148	1162148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1162148C>T	ENST00000381894.3	-	2	786	c.115G>A	c.(115-117)Ggt>Agt	p.G39S	TMEM74B_ENST00000481747.1_5'UTR	NM_018354.1	NP_060824.1	Q9NUR3	CT046_HUMAN	transmembrane protein 74B	39						integral to membrane	protein binding										GCTTGGGGACCATTGCTCAGT	0.602000													4	53					0	0	1	0	0
DCLRE1C	64421	broad.mit.edu	37	10	14950960	14950960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:14950960G>A	ENST00000453695.2	-	14	1610	c.1166C>T	c.(1165-1167)tCc>tTc	p.S389F	DCLRE1C_ENST00000378246.2_Missense_Mutation_p.S394F|DCLRE1C_ENST00000378289.4_Intron|DCLRE1C_ENST00000378242.1_Missense_Mutation_p.S162F|DCLRE1C_ENST00000492201.1_5'UTR|DCLRE1C_ENST00000378258.1_Missense_Mutation_p.S389F|DCLRE1C_ENST00000396817.2_Missense_Mutation_p.S389F|DCLRE1C_ENST00000378249.1_Missense_Mutation_p.S394F|DCLRE1C_ENST00000357717.2_Missense_Mutation_p.S394F|DCLRE1C_ENST00000378278.2_Missense_Mutation_p.S509F|DCLRE1C_ENST00000378254.1_Missense_Mutation_p.S389F|DCLRE1C_ENST00000378255.1_Missense_Mutation_p.S389F	NM_001033855.1	NP_001029027.1	Q96SD1	DCR1C_HUMAN	DNA cross-link repair 1C	509					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	17						CACTGTGGAGGAAGGGAAGTT	0.458000								Non-homologous end-joining					13	36					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130308020	130308020	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130308020G>A	ENST00000358511.6	+	11	4243	c.4212G>A	c.(4210-4212)ggG>ggA	p.G1404G	COL6A6_ENST00000453409.2_Silent_p.G1404G	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1404	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GACCACCAGGGAAAAGGGTGA	0.433000													9	26					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17941319	17941319	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17941319G>A	ENST00000458235.1	-	22	3188	c.3089C>T	c.(3088-3090)cCc>cTc	p.P1030L	JAK3_ENST00000534444.1_Missense_Mutation_p.P1030L|JAK3_ENST00000527670.1_Missense_Mutation_p.P1030L	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	1030	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						CACGGCCGAGGGGCTGCAGCT	0.617000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								7	17					0	0	1	0	0
ISYNA1	51477	broad.mit.edu	37	19	18547253	18547253	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18547253A>T	ENST00000545187.1	-	3	482	c.196T>A	c.(196-198)Tct>Act	p.S66T	ISYNA1_ENST00000578963.1_Missense_Mutation_p.S88T|ISYNA1_ENST00000338128.7_Missense_Mutation_p.S216T|ISYNA1_ENST00000317018.6_Missense_Mutation_p.S14T|ISYNA1_ENST00000457269.3_Missense_Mutation_p.S162T			Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	216					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			breast(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	12						CCCGCGCTAGACCGGAAGTCT	0.587000													39	95					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55266593	55266593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55266593C>T	ENST00000340465.2	+	9	1213	c.1127C>T	c.(1126-1128)tCc>tTc	p.S376F		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	376						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TACAGAACTTCCAGAATATCA	0.358000													16	68					0	0	1	0	0
IL12RB2	3595	broad.mit.edu	37	1	67861377	67861377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:67861377G>A	ENST00000262345.1	+	16	2834	c.2194G>A	c.(2194-2196)Gga>Aga	p.G732R	IL12RB2_ENST00000544434.1_Missense_Mutation_p.G646R|IL12RB2_ENST00000371000.1_3'UTR|IL12RB2_ENST00000465396.1_3'UTR|IL12RB2_ENST00000541374.1_3'UTR	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	732					positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						AAGGGAAAAAGGAATCCAAGG	0.532000													18	52					0	0	1	0	0
SLC29A3	55315	broad.mit.edu	37	10	73122195	73122195	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73122195T>G	ENST00000373189.5	+	6	1310	c.1258T>G	c.(1258-1260)Tcc>Gcc	p.S420A	SLC29A3_ENST00000469204.1_3'UTR	NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	420					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						ACTCCTCAGCTCCCTGCTGGG	0.632000													30	90					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21462834	21462834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:21462834G>A	ENST00000281523.2	-	8	1578	c.1060C>T	c.(1060-1062)Ccc>Tcc	p.P354S		NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	354						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						AGACTGAAGGGGGAACTCAct	0.557000													6	24					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136564845	136564845	+	Silent	SNP	C	C	T	rs150640616		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136564845C>T	ENST00000264162.2	-	9	4036	c.4026G>A	c.(4024-4026)acG>acA	p.T1342T		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1342	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGGCCTGTTCGTGTTGTTGA	0.522000													47	79					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6428018	6428018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6428018C>T	ENST00000449001.2	+	11	1781	c.1287C>T	c.(1285-1287)ctC>ctT	p.L429L	PLEKHG6_ENST00000011684.7_Silent_p.L461L|PLEKHG6_ENST00000536531.1_Silent_p.L461L|PLEKHG6_ENST00000396988.3_Silent_p.L461L	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	461	PH.				regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						TGGAGAAGCTCGTGTGCCAAC	0.582000													12	46					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48381938	48381938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48381938C>T	ENST00000224600.4	-	4	3824	c.3711G>A	c.(3709-3711)gtG>gtA	p.V1237V		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1237					lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GGCTCCGCTTCACCCTCAGCT	0.647000													4	20					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23549177	23549177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23549177G>A	ENST00000262710.1	-	6	1868	c.1541C>T	c.(1540-1542)gCc>gTc	p.A514V	ACIN1_ENST00000457657.1_Missense_Mutation_p.A474V|ACIN1_ENST00000555053.1_Missense_Mutation_p.A514V|ACIN1_ENST00000605057.1_Missense_Mutation_p.A456V	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	514					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ATCCTTCTGGGCTGAGTAGTC	0.493000													61	94					0	0	1	0	0
CNNM4	26504	broad.mit.edu	37	2	97427263	97427263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97427263C>T	ENST00000377075.2	+	1	625	c.527C>T	c.(526-528)cCt>cTt	p.P176L		NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	176					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						GTGGAGGAGCCTGGGAGGTTC	0.602000													110	257					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685672	125685672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:125685672C>T	ENST00000371126.1	-	1	1162	c.920G>A	c.(919-921)cGg>cAg	p.R307Q		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	307										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CACATTATCCCGGAAGTAGGG	0.582000													34	26					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40345098	40345098	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40345098A>G	ENST00000280871.4	-	4	1045	c.995T>C	c.(994-996)cTa>cCa	p.L332P	SLC2A13_ENST00000380858.1_Missense_Mutation_p.L332P	NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	332						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				GAACATTTGTAGGCCACAACC	0.373000										HNSCC(50;0.14)			8	65					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584932	82584932	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82584932C>T	ENST00000423517.2	-	5	5674	c.5337G>A	c.(5335-5337)ttG>ttA	p.L1779L	PCLO_ENST00000333891.8_Silent_p.L1779L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1710					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTTCCTCTCTCAATTCTTCTT	0.393000													39	86					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27444208	27444208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27444208C>T	ENST00000264705.4	+	3	507	c.345C>T	c.(343-345)ggC>ggT	p.G115G	CAD_ENST00000403525.1_Silent_p.G115G	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	115	GATase (Glutamine amidotransferase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCATCCCTGGCTTGCAAGGTA	0.567000													10	19					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9943624	9943624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9943624G>A	ENST00000396573.2	-	6	1626	c.1317C>T	c.(1315-1317)ttC>ttT	p.F439F	GRIN2A_ENST00000404927.2_Silent_p.F439F|GRIN2A_ENST00000562109.1_Silent_p.F439F|GRIN2A_ENST00000330684.3_Silent_p.F439F|GRIN2A_ENST00000396575.2_Silent_p.F439F|GRIN2A_ENST00000535259.1_Silent_p.F282F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	439					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGATTTTGACGAACTTCCGAC	0.502000													30	74					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40935959	40935959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40935959C>T	ENST00000246914.5	+	3	817	c.796C>T	c.(796-798)Ctg>Ttg	p.L266L		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	266	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCCCAGGTACCTGAGGCGGTT	0.672000													5	18					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034594	52034594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52034594C>T	ENST00000346477.3	-	2	315	c.247G>A	c.(247-249)Gaa>Aaa	p.E83K	SIGLEC6_ENST00000359982.4_Missense_Mutation_p.E83K|SIGLEC6_ENST00000391797.3_Missense_Mutation_p.E83K|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.E83K|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.E47K|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.E83K	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	83	Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGCACTTCTTCGTCTGGGTCG	0.582000													31	92					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29287358	29287358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29287358G>A	ENST00000266943.6	-	3	888	c.519C>T	c.(517-519)gaC>gaT	p.D173D	SLC46A3_ENST00000380814.4_Silent_p.D173D	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	173					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		CAAGTAGAAAGTCAATGATAG	0.368000													27	47					0	0	1	0	0
ZNF138	7697	broad.mit.edu	37	7	64292248	64292248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:64292248C>T	ENST00000359735.3	+	4	804	c.457C>T	c.(457-459)Ctt>Ttt	p.L153F	ZNF138_ENST00000430838.2_3'UTR|ZNF138_ENST00000440155.2_Missense_Mutation_p.L184F|ZNF138_ENST00000440598.1_3'UTR|ZNF138_ENST00000437743.1_Missense_Mutation_p.L178F|ZNF138_ENST00000397136.2_Missense_Mutation_p.L153F|ZNF138_ENST00000307355.7_Missense_Mutation_p.L210F	NM_001271637.1|NM_001271639.1	NP_001258566.1|NP_001258568.1	B4DP87	B4DP87_HUMAN	zinc finger protein 138	184					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(2)|stomach(1)	7		Lung NSC(55;0.0795)|all_lung(88;0.18)				GTCCACAAACCTTTCTAAACC	0.343000													15	40					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951115	38951115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38951115C>T	ENST00000355481.4	+	20	2592	c.2461C>T	c.(2461-2463)Cat>Tat	p.H821Y	RYR1_ENST00000360985.3_Missense_Mutation_p.H821Y|RYR1_ENST00000359596.3_Missense_Mutation_p.H821Y	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	821					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGAGCGACTCCATCTTGAACC	0.647000													40	120					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42828080	42828080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42828080C>T	ENST00000314073.5	+	11	2511	c.2335C>T	c.(2335-2337)Cta>Tta	p.L779L	GLTSCR1L_ENST00000394168.1_Silent_p.L779L					GLTSCR1-like																		ATGCCTGCTCCTAGAAGATGC	0.383000													52	110					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111779739	111779739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111779739G>A	ENST00000261726.6	+	21	3695	c.3541G>A	c.(3541-3543)Gag>Aag	p.E1181K		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1181						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CGAGGAGAAGGAGGCACTGCG	0.642000													7	89					0	0	1	0	0
SMAD6	4091	broad.mit.edu	37	15	67073660	67073660	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:67073660C>T	ENST00000288840.5	+	4	2309	c.1278C>T	c.(1276-1278)gtC>gtT	p.V426V	SMAD6_ENST00000338426.4_Silent_p.V165V	NM_005585.4	NP_005576.3	O43541	SMAD6_HUMAN	SMAD family member 6	426	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			lung(1)|skin(1)	2						GCGCCCTGGTCGTGCGCAAGG	0.731000													10	37					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55976628	55976628	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55976628G>A	ENST00000263923.4	-	9	1492	c.1197C>T	c.(1195-1197)atC>atT	p.I399I		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	399	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GATTGGTAAGGATGACAGTGT	0.423000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			31	67					0	0	1	0	0
SGOL1	151648	broad.mit.edu	37	3	20216529	20216529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:20216529G>A	ENST00000412997.1	-	6	845	c.494C>T	c.(493-495)cCt>cTt	p.P165L	SGOL1_ENST00000306698.2_Intron|SGOL1_ENST00000442720.1_Intron|SGOL1_ENST00000417364.1_Missense_Mutation_p.P165L|SGOL1-AS1_ENST00000441442.1_RNA|SGOL1_ENST00000383774.1_Missense_Mutation_p.P165L|SGOL1_ENST00000425061.1_Missense_Mutation_p.P165L|SGOL1_ENST00000419233.2_Missense_Mutation_p.P165L|SGOL1-AS1_ENST00000448208.1_RNA|SGOL1_ENST00000437051.1_Missense_Mutation_p.P165L|SGOL1_ENST00000452020.1_Intron|SGOL1_ENST00000443724.1_Missense_Mutation_p.P165L|SGOL1_ENST00000421451.1_Missense_Mutation_p.P165L|SGOL1_ENST00000429446.3_Intron|SGOL1_ENST00000263753.4_Missense_Mutation_p.P165L|SGOL1_ENST00000412868.1_Missense_Mutation_p.P165L	NM_001199251.1	NP_001186180.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	165	Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						TGTGTCTTGAGGAATAGTAGG	0.308000													22	43					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043742	20043742	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20043742C>T	ENST00000570682.1	-	2	677	c.377G>A	c.(376-378)aGg>aAg	p.R126K		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	126						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						AGCGATATACCTGTCAATGGT	0.502000													24	73					0	0	1	0	0
RIC3	79608	broad.mit.edu	37	11	8148302	8148302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8148302G>A	ENST00000396677.2	-	2	87	c.88C>T	c.(88-90)Cga>Tga	p.R30*	RIC3_ENST00000335425.7_Intron|RIC3_ENST00000539720.1_Nonsense_Mutation_p.R143*|RIC3_ENST00000343202.4_Nonsense_Mutation_p.R191*|RIC3_ENST00000530060.1_5'UTR|RIC3_ENST00000309737.6_Nonsense_Mutation_p.R192*|RIC3_ENST00000425599.2_Intron			Q7Z5B4	RIC3_HUMAN	RIC3 acetylcholine receptor chaperone	192						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		GTGATTTCTCGGAGCTGATGT	0.443000													18	56					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41525904	41525904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41525904C>T	ENST00000396942.1	-	39	5358	c.5275G>A	c.(5275-5277)Gag>Aag	p.E1759K	ANK1_ENST00000352337.4_Missense_Mutation_p.E1759K|ANK1_ENST00000396945.1_Missense_Mutation_p.E1759K|ANK1_ENST00000289734.7_Missense_Mutation_p.E1759K|ANK1_ENST00000379758.2_Missense_Mutation_p.E1759K|ANK1_ENST00000265709.8_Missense_Mutation_p.E1800K|ANK1_ENST00000347528.4_Missense_Mutation_p.E1759K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1759	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CACGTGTGCTCACTTACAGAC	0.592000													25	57					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228525070	228525070	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228525070G>A	ENST00000570156.2	+	77	19731	c.19657G>A	c.(19657-19659)Gat>Aat	p.D6553N	OBSCN_ENST00000366707.4_Missense_Mutation_p.D3230N|OBSCN_ENST00000422127.1_Missense_Mutation_p.D5596N|OBSCN_ENST00000284548.11_Missense_Mutation_p.D5596N|OBSCN_ENST00000366709.4_Missense_Mutation_p.D2715N	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5596	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGAGGACGGCGATGCCCGAGG	0.642000													4	12					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45475276	45475276	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:45475276C>A	ENST00000361462.2	+	5	2893	c.2710C>A	c.(2710-2712)Cga>Aga	p.R904R	FAM179B_ENST00000382233.2_Silent_p.R904R|KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Silent_p.R904R			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	904							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						GCCATCTTCCCGACGAGGTCT	0.413000													40	149					9.62906e-15	9.67986e-15	1	1	0
MUC16	94025	broad.mit.edu	37	19	9069821	9069821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9069821G>A	ENST00000397910.4	-	3	17828	c.17625C>T	c.(17623-17625)acC>acT	p.T5875T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5877	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAGGGTAAGGGTAGCCTGTG	0.493000													36	94					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175046766	175046766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175046766C>T	ENST00000239462.4	+	2	325	c.212C>T	c.(211-213)tCg>tTg	p.S71L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	71					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GATGGGGCTTCGCTCTTGGCC	0.587000													11	31					0	0	1	0	0
ATG3	64422	broad.mit.edu	37	3	112251591	112251591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112251591G>A	ENST00000283290.5	-	12	1334	c.900C>T	c.(898-900)gtC>gtT	p.V300V	ATG3_ENST00000402314.2_3'UTR	NM_022488.3	NP_071933.2	Q9NT62	ATG3_HUMAN	autophagy related 3	300					autophagic vacuole assembly|mitochondrial fragmentation involved in apoptosis|protein targeting to membrane|protein ubiquitination	cytoplasmic ubiquitin ligase complex|cytosol	Atg12 ligase activity|Atg8 ligase activity|enzyme binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(3)	9						TTGTTGGAATGACAGCTTGTA	0.284000													32	56					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597061	136597061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136597061C>T	ENST00000531224.1	-	5	1854	c.1602G>A	c.(1600-1602)agG>agA	p.R534R	BCLAF1_ENST00000392348.2_Silent_p.R532R|BCLAF1_ENST00000530767.1_Silent_p.R361R|BCLAF1_ENST00000527759.1_Silent_p.R532R|BCLAF1_ENST00000527536.1_Silent_p.R534R|BCLAF1_ENST00000353331.4_Silent_p.R532R	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	534					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding	p.R534S(1)		haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCATTTTGATCCTAAGTGGGC	0.433000													45	264					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52522557	52522557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52522557C>T	ENST00000345716.4	+	16	3183	c.3049C>T	c.(3049-3051)Ccc>Tcc	p.P1017S	NISCH_ENST00000479054.1_Missense_Mutation_p.P1017S	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	1017					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CGCCAAGACCCCCGGGACGGG	0.677000													19	38					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2714298	2714298	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2714298G>A	ENST00000399655.1	+	23	3277	c.3012G>A	c.(3010-3012)agG>agA	p.R1004R	CACNA1C_ENST00000399637.1_Silent_p.R1004R|CACNA1C_ENST00000480911.1_Silent_p.R1004R|CACNA1C_ENST00000335762.5_Silent_p.R1029R|CACNA1C_ENST00000399603.1_Silent_p.R1004R|CACNA1C_ENST00000399649.1_Silent_p.R1004R|CACNA1C_ENST00000399595.1_Silent_p.R1004R|CACNA1C_ENST00000399606.1_Silent_p.R1024R|CACNA1C_ENST00000399601.1_Silent_p.R1004R|CACNA1C_ENST00000399617.1_Silent_p.R1004R|CACNA1C_ENST00000344100.3_Silent_p.R1004R|CACNA1C_ENST00000399621.1_Silent_p.R1004R|CACNA1C_ENST00000399629.1_Silent_p.R1004R|CACNA1C_ENST00000327702.7_Silent_p.R1004R|CACNA1C_ENST00000406454.3_Silent_p.R1004R|CACNA1C_ENST00000402845.3_Silent_p.R1004R|CACNA1C_ENST00000399597.1_Silent_p.R1004R|CACNA1C_ENST00000347598.4_Silent_p.R1024R|CACNA1C_ENST00000399641.1_Silent_p.R1004R|CACNA1C_ENST00000399638.1_Silent_p.R1004R|CACNA1C_ENST00000399644.1_Silent_p.R1004R|CACNA1C_ENST00000399591.1_Silent_p.R1004R|CACNA1C-AS3_ENST00000543559.1_RNA|CACNA1C_ENST00000399634.1_Silent_p.R1004R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1024					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GAGTACTCAGGCCCCTGAGGG	0.592000													7	50					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8235575	8235575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8235575C>T	ENST00000520004.1	-	3	608	c.344G>A	c.(343-345)cGa>cAa	p.R115Q	SGK223_ENST00000330777.4_Missense_Mutation_p.R115Q			Q86YV5	SG223_HUMAN		115							ATP binding|non-membrane spanning protein tyrosine kinase activity										GCCAGGGGCTCGTCTCCAGAT	0.547000													30	83					0	0	1	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43802323	43802323	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43802323C>T	ENST00000291532.3	-	9	1758	c.803G>A	c.(802-804)tGg>tAg	p.W268*	TMPRSS3_ENST00000398405.1_Nonsense_Mutation_p.W266*|TMPRSS3_ENST00000474596.1_5'UTR|TMPRSS3_ENST00000398397.3_Nonsense_Mutation_p.W268*|TMPRSS3_ENST00000433957.2_Nonsense_Mutation_p.W268*|TMPRSS3_ENST00000380399.1_Nonsense_Mutation_p.W352*	NM_032404.2	NP_115780.1	P57727	TMPS3_HUMAN	transmembrane protease, serine 3	268	Peptidase S1.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						CTGGATGGTCCATGACTTGGG	0.498000													14	39					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20406640	20406640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20406640C>T	ENST00000222573.3	+	3	903	c.219C>T	c.(217-219)ttC>ttT	p.F73F	ITGB8_ENST00000537992.1_5'UTR	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	73					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						AACAGGATTTCATTTCAGGTG	0.303000													39	88					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40351347	40351347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40351347G>A	ENST00000310169.2	+	4	953	c.814G>A	c.(814-816)Gga>Aga	p.G272R		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	272					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	GGTCTCCCTGGGAGTGACCAT	0.502000													79	220					0	0	1	0	0
OR2Y1	134083	broad.mit.edu	37	5	180166987	180166987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180166987C>T	ENST00000307832.2	-	1	112	c.72G>A	c.(70-72)gaG>gaA	p.E24E		NM_001001657.1	NP_001001657.1	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y, member 1	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGGATGGGCTCCAGTTGCG	0.473000													11	32					0	0	1	0	0
RSPO3	84870	broad.mit.edu	37	6	127476394	127476394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:127476394G>A	ENST00000356698.4	+	4	1034	c.445G>A	c.(445-447)Gag>Aag	p.E149K	RSPO3_ENST00000368317.3_Missense_Mutation_p.E149K|RSPO3_ENST00000485757.1_3'UTR	NM_032784.3	NP_116173.2	Q9BXY4	RSPO3_HUMAN	R-spondin 3	149	TSP type-1.					extracellular region	heparin binding		PTPRK/RSPO3(10)	breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17				GBM - Glioblastoma multiforme(226;0.0555)		AGTGCACTGTGAGGTCAGTGA	0.428000													57	96					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207640026	207640026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207640026G>A	ENST00000367057.3	+	2	403	c.214G>A	c.(214-216)Gat>Aat	p.D72N	CR2_ENST00000367059.3_Missense_Mutation_p.D72N|CR2_ENST00000458541.2_Missense_Mutation_p.D72N|CR2_ENST00000367058.3_Missense_Mutation_p.D72N	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	72	Sushi 1.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						AGACAAAGTGGATGGAACCTG	0.413000													48	109					0	0	1	0	0
NR0B2	8431	broad.mit.edu	37	1	27238410	27238410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27238410C>T	ENST00000254227.3	-	2	725	c.700G>A	c.(700-702)Gac>Aac	p.D234N		NM_021969.2	NP_068804.1	Q15466	NR0B2_HUMAN	nuclear receptor subfamily 0, group B, member 2	234					cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity			NS(1)|large_intestine(1)|lung(3)	5		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		AAGAAGAGGTCCCCAAGCAGG	0.597000													34	130					0	0	1	0	0
ERLIN1	10613	broad.mit.edu	37	10	101912014	101912014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101912014G>A	ENST00000421367.2	-	11	3628	c.921C>T	c.(919-921)ttC>ttT	p.F307F	ERLIN1_ENST00000407654.3_Silent_p.F307F	NM_001100626.1|NM_006459.3	NP_001094096.1|NP_006450.2	O75477	ERLN1_HUMAN	ER lipid raft associated 1	305					ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding						Colorectal(252;0.234)		Epithelial(162;3.85e-10)|all cancers(201;3.25e-08)		AGGAGTCCACGAACATGTTAG	0.458000													17	76					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71712665	71712665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71712665G>A	ENST00000356340.3	+	37	2589	c.2053G>A	c.(2053-2055)Ggg>Agg	p.G685R	COL13A1_ENST00000398968.3_Missense_Mutation_p.G666R|COL13A1_ENST00000520133.1_Intron|COL13A1_ENST00000398966.3_Missense_Mutation_p.G663R|COL13A1_ENST00000398969.3_Missense_Mutation_p.G613R|COL13A1_ENST00000398974.3_Missense_Mutation_p.G673R|COL13A1_ENST00000398972.3_Missense_Mutation_p.G671R|COL13A1_ENST00000398973.3_Missense_Mutation_p.G659R|COL13A1_ENST00000398971.3_Missense_Mutation_p.G670R|COL13A1_ENST00000520267.1_Missense_Mutation_p.G613R|COL13A1_ENST00000398964.3_Missense_Mutation_p.G656R|COL13A1_ENST00000357811.3_Missense_Mutation_p.G651R|COL13A1_ENST00000354547.3_Missense_Mutation_p.G663R|COL13A1_ENST00000517713.1_Missense_Mutation_p.G636R|COL13A1_ENST00000522165.1_Missense_Mutation_p.G654R|COL13A1_ENST00000398978.3_Missense_Mutation_p.G685R			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	685	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AGGCTCTAGAGGGCCTAAAGG	0.428000													21	64					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	20998675	20998675	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20998675C>T	ENST00000247986.2	-	12	2788	c.2478G>A	c.(2476-2478)gaG>gaA	p.E826E	KIF17_ENST00000490034.1_5'UTR|KIF17_ENST00000400463.3_Silent_p.E826E|KIF17_ENST00000375044.1_Silent_p.E726E			Q9P2E2	KIF17_HUMAN	kinesin family member 17	826					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TGATCTCCACCTCTGCTGCCC	0.557000													9	27					0	0	1	0	0
HHATL	57467	broad.mit.edu	37	3	42739045	42739045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42739045G>A	ENST00000441594.1	-	7	1081	c.820C>T	c.(820-822)Ccc>Tcc	p.P274S	HHATL_ENST00000310417.5_Missense_Mutation_p.P274S	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	274					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		AGGTCGCTGGGGATAGTGAGG	0.612000													43	89					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178140442	178140442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178140442G>A	ENST00000335815.2	-	5	634	c.437C>T	c.(436-438)tCa>tTa	p.S146L		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	146					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		GTGGGTGGCTGAAACTATCTG	0.363000													69	126					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022865	76022865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76022865C>T	ENST00000393004.2	-	5	2904	c.2683G>A	c.(2683-2685)Ggg>Agg	p.G895R	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.G895R|FILIP1_ENST00000370020.1_Missense_Mutation_p.G796R			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	895										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CCTGGGTGCCCTGGACTGGAA	0.532000													9	100					0	0	1	0	0
LGMN	5641	broad.mit.edu	37	14	93185157	93185157	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93185157G>A	ENST00000393218.2	-	4	508	c.171C>T	c.(169-171)caC>caT	p.H57H	LGMN_ENST00000334869.4_Silent_p.H57H|LGMN_ENST00000555699.1_Silent_p.H57H|LGMN_ENST00000557434.1_Silent_p.H57H	NM_001008530.2	NP_001008530.1	Q99538	LGMN_HUMAN	legumain	57					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|skin(2)	18		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		TCCCATTGCGGTGAATGATCT	0.483000													27	81					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230924019	230924019	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230924019T>C	ENST00000295190.4	-	2	508	c.50A>G	c.(49-51)aAa>aGa	p.K17R		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	17						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		CTTTTTGTCTTTGGGGCCATC	0.408000													5	69					0	0	1	0	0
PPP1R1A	5502	broad.mit.edu	37	12	54971195	54971195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54971195C>T	ENST00000547431.1	-	6	466	c.439G>A	c.(439-441)Gac>Aac	p.D147N	PDE1B_ENST00000394277.3_Intron|PDE1B_ENST00000538346.1_Intron|PDE1B_ENST00000243052.3_Intron|PDE1B_ENST00000550620.1_Intron			Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1A	21	Interaction with PPP1R15A.		G -> D (in dbSNP:rs34376731).		glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			lung(2)	2						GTTGGGTCGTCTCTGGGCTCC	0.542000													84	190					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10222305	10222305	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10222305C>T	ENST00000418404.3	-	26	3703	c.3540G>A	c.(3538-3540)agG>agA	p.R1180R	MYH13_ENST00000570743.1_Silent_p.R1180R|MYH13_ENST00000252172.4_Silent_p.R1180R			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1180					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCTCCAGGTCCCTGCGCATTT	0.582000													94	77					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140362060	140362060	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140362060C>T	ENST00000532602.1	+	3	3487	c.2453_splice	c.e3-1	p.S818_splice	PCDHA6_ENST00000527624.1_Splice_Site_p.S554_splice|PCDHA12_ENST00000398631.2_Splice_Site_p.S809_splice|PCDHA13_ENST00000409494.1_Splice_Site_p.S818_splice|PCDHAC1_ENST00000253807.2_Splice_Site_p.S831_splice|PCDHA6_ENST00000529310.1_Splice_Site_p.S818_splice|PCDHA1_ENST00000394633.3_Splice_Site_p.S554_splice|PCDHA5_ENST00000529619.1_Splice_Site_p.S804_splice|PCDHA10_ENST00000307360.5_Splice_Site_p.S816_splice|PCDHA8_ENST00000531613.1_Splice_Site_p.S818_splice|PCDHA13_ENST00000289272.2_Splice_Site_p.S818_splice|PCDHA4_ENST00000512229.2_Splice_Site_p.S815_splice|PCDHA11_ENST00000398640.2_Splice_Site_p.S817_splice|PCDHA1_ENST00000504120.2_Splice_Site_p.S818_splice|PCDHAC2_ENST00000289269.5_Splice_Site_p.S875_splice|PCDHA3_ENST00000522353.2_Splice_Site_p.S818_splice|PCDHA10_ENST00000506939.2_Splice_Site_p.S553_splice|PCDHA2_ENST00000526136.1_Splice_Site_p.S816_splice|PCDHA7_ENST00000525929.1_Splice_Site_p.S805_splice|PCDHA4_ENST00000530339.1_Splice_Site_p.S815_splice|PCDHA5_ENST00000529859.1_Splice_Site_p.S804_splice	NM_031857.1	NP_114063.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTATTCAGCTCTGTGCACC	0.502000													28	56					0	0	1	0	0
OTX2	5015	broad.mit.edu	37	14	57268695	57268695	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:57268695G>A	ENST00000339475.5	-	5	928	c.652C>T	c.(652-654)Cac>Tac	p.H218Y	OTX2_ENST00000408990.3_Missense_Mutation_p.H210Y|OTX2_ENST00000554788.1_3'UTR|OTX2_ENST00000555006.1_Missense_Mutation_p.H210Y	NM_001270523.1|NM_001270524.1|NM_001270525.1|NM_021728.3	NP_001257452.1|NP_001257453.1|NP_001257454.1|NP_068374.1	P32243	OTX2_HUMAN	orthodenticle homeobox 2	210					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	19	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					GGAAGCTGGTGATGCATAGGG	0.522000													20	47					0	0	1	0	0
SPATA19	219938	broad.mit.edu	37	11	133712390	133712390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:133712390C>T	ENST00000299140.3	-	5	481	c.427G>A	c.(427-429)Gtg>Atg	p.V143M	SPATA19_ENST00000532889.1_Missense_Mutation_p.V143M	NM_174927.1	NP_777587.1	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19	143					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane				cervix(1)|endometrium(2)|large_intestine(2)|lung(5)|prostate(1)	11	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		CTTCGTCTCACCTGCTCTATT	0.532000													40	93					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18030129	18030129	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18030129C>T	ENST00000205890.5	+	6	4229	c.3891C>T	c.(3889-3891)ctC>ctT	p.L1297L		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1297	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TTGCAAATCTCGCCTTCGCCA	0.547000													79	91					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271920	22271920	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22271920G>A	ENST00000594947.1	+	4	1512	c.1368G>A	c.(1366-1368)gaG>gaA	p.E456E		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATACTGGAGAGAAACCCTACA	0.393000													24	55					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122387215	122387215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:122387215G>A	ENST00000264357.5	+	3	622	c.330G>A	c.(328-330)atG>atA	p.M110I	GRIA3_ENST00000542149.1_Missense_Mutation_p.M110I|GRIA3_ENST00000479118.1_3'UTR|GRIA3_ENST00000541091.1_Missense_Mutation_p.M94I|GRIA3_ENST00000371256.5_Missense_Mutation_p.M110I|GRIA3_ENST00000371251.1_Missense_Mutation_p.M110I	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	110					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	AGATGTCAATGAACACCCTGA	0.498000													73	50					0	0	1	0	0
SIK2	23235	broad.mit.edu	37	11	111572220	111572220	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111572220C>T	ENST00000304987.3	+	6	821	c.648C>T	c.(646-648)ccC>ccT	p.P216P		NM_015191.1	NP_056006.1	Q9H0K1	SIK2_HUMAN	salt-inducible kinase 2	216	Protein kinase.				intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	30						GAGCTCTGCCCTTTGATGGAC	0.423000													20	201					0	0	1	0	0
HOXA3	3200	broad.mit.edu	37	7	27148074	27148074	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27148074T>C	ENST00000396352.4	-	3	991	c.792A>G	c.(790-792)ccA>ccG	p.P264P	HOXA3_ENST00000317201.2_Silent_p.P264P|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	264					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						GGCTGCGACTTGGAGACTGGC	0.602000													50	129					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885727	29885727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29885727G>A	ENST00000310624.6	+	4	2131	c.2098G>A	c.(2098-2100)Gaa>Aaa	p.E700K		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	706	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						CCCAGTGAAGGAAGAAGCAAA	0.557000													53	145					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140596022	140596022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140596022C>T	ENST00000341948.4	+	1	2514	c.2327C>T	c.(2326-2328)cCc>cTc	p.P776L		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		776					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.P776H(1)		NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTTCCCTCCCCAGTGCCCT	0.468000													55	118					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54314322	54314322	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54314322C>T	ENST00000324134.6	-	3	759	c.591G>A	c.(589-591)gaG>gaA	p.E197E	NLRP12_ENST00000391772.1_Silent_p.E197E|NLRP12_ENST00000535162.1_Silent_p.E197E|NLRP12_ENST00000391773.1_Silent_p.E197E|NLRP12_ENST00000354278.3_Silent_p.E197E|NLRP12_ENST00000391775.3_Silent_p.E197E|NLRP12_ENST00000351894.4_Silent_p.E197E|NLRP12_ENST00000345770.5_Silent_p.E197E	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	197					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAAAGAGGGTCTCTATCTTGA	0.637000													7	112					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92523184	92523184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92523184G>A	ENST00000298047.6	+	7	4428	c.4411G>A	c.(4411-4413)Gag>Aag	p.E1471K	FAT3_ENST00000409404.2_Missense_Mutation_p.E1471K|FAT3_ENST00000525166.1_Missense_Mutation_p.E1321K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1471	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACAATTTCCGAGGATGTGCT	0.423000										TCGA Ovarian(4;0.039)			21	99					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099913	133099913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133099913G>A	ENST00000515826.1	+	3	1481	c.1358G>A	c.(1357-1359)gGg>gAg	p.G453E	TMEM108_ENST00000393130.3_Missense_Mutation_p.G453E|TMEM108_ENST00000321871.6_Missense_Mutation_p.G453E|TMEM108_ENST00000508711.1_Intron			Q6UXF1	TM108_HUMAN	transmembrane protein 108	453						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GTGGCCGAGGGGGACAAACCG	0.612000													12	91					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73748388	73748388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73748388G>A	ENST00000200181.3	+	31	4114	c.3927G>A	c.(3925-3927)gaG>gaA	p.E1309E	ITGB4_ENST00000339591.3_Silent_p.E1309E|ITGB4_ENST00000450894.3_Silent_p.E1309E|ITGB4_ENST00000579662.1_Silent_p.E1309E|GALK1_ENST00000225614.2_Intron|ITGB4_ENST00000449880.2_Silent_p.E1309E	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1309	Fibronectin type-III 2.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGGGCCTGAGCGGGAGGCCA	0.672000													30	90					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8176871	8176871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8176871G>A	ENST00000600128.1	-	31	4365	c.3951C>T	c.(3949-3951)ttC>ttT	p.F1317F	FBN3_ENST00000601739.1_Silent_p.F1317F|FBN3_ENST00000270509.2_Silent_p.F1317F			Q75N90	FBN3_HUMAN	fibrillin 3	1317	EGF-like 19; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CGTGACATTCGAAGCCATCCC	0.637000													35	60					0	0	1	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18165325	18165325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:18165325C>T	ENST00000278816.2	+	10	2714	c.2064C>T	c.(2062-2064)ggC>ggT	p.G688G	CSRP2BP_ENST00000435364.2_Silent_p.G688G|CSRP2BP_ENST00000489634.2_Silent_p.G560G|CSRP2BP_ENST00000377681.2_Silent_p.G687G			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	688	N-acetyltransferase.				histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						TTGCCTTTGGCTTCATGGTTC	0.408000													42	86					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42173354	42173354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42173354G>A	ENST00000320955.6	-	13	2763	c.2536C>T	c.(2536-2538)Cct>Tct	p.P846S		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	846					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCATCCCCAGGGCCAGGGTGG	0.602000													23	33					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100796699	100796699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:100796699C>T	ENST00000358544.2	+	43	8122	c.8011C>T	c.(8011-8013)Cca>Tca	p.P2671S	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.P2646S	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2671					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCACAAATCCCCACAGGTATT	0.473000													24	105					0	0	1	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20470032	20470032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20470032G>A	ENST00000375102.3	+	3	365	c.263G>A	c.(262-264)gGt>gAt	p.G88D		NM_022819.3	NP_073730.3	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	45					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GTGGGCTACGGTTGCTACTGT	0.637000													16	73					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123444423	123444423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123444423G>A	ENST00000542678.1	-	2	3198	c.360C>T	c.(358-360)ttC>ttT	p.F120F	ABCB9_ENST00000442833.2_Silent_p.F120F|ABCB9_ENST00000280560.8_Silent_p.F120F|ABCB9_ENST00000392439.3_Silent_p.F120F|ABCB9_ENST00000442028.2_Silent_p.F120F|ABCB9_ENST00000344275.7_Silent_p.F120F|ABCB9_ENST00000346530.5_Silent_p.F120F|ABCB9_ENST00000540285.1_Silent_p.F120F			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	120					positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		ACGTCCACACGAACAGGGCCC	0.657000													10	21					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664151	44664151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44664151G>A	ENST00000454036.1	+	3	401	c.325G>A	c.(325-327)Ggt>Agt	p.G109S	SLC12A5_ENST00000539566.1_Missense_Mutation_p.G86S|SLC12A5_ENST00000372315.1_Missense_Mutation_p.G86S|SLC12A5_ENST00000243964.3_Missense_Mutation_p.G86S	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	109					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAACAATGAGGGTGGAAAAAA	0.572000													22	52					0	0	1	0	0
F2RL2	2151	broad.mit.edu	37	5	75914387	75914387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75914387C>T	ENST00000296641.4	-	2	348	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	IQGAP2_ENST00000396234.3_Intron|IQGAP2_ENST00000502745.1_Intron|F2RL2_ENST00000504899.1_Missense_Mutation_p.E27K|IQGAP2_ENST00000274364.6_Intron|IQGAP2_ENST00000379730.3_Intron	NM_004101.3	NP_004092.1	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	49					platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(3)	32		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		GGGAACTCTTCAAAAGAATTT	0.418000													48	121					0	0	1	0	0
C9orf152	401546	broad.mit.edu	37	9	112963672	112963672	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112963672T>C	ENST00000400613.4	-	2	885	c.276A>G	c.(274-276)gaA>gaG	p.E92E	C9orf152_ENST00000473442.1_Intron	NM_001012993.2	NP_001013011.2	Q5JTZ5	CI152_HUMAN	chromosome 9 open reading frame 152	92										NS(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						AATCTGCCTCTTCCAGGGACA	0.552000													10	49					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20144725	20144725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20144725G>A	ENST00000245957.5	+	11	1134	c.1058G>A	c.(1057-1059)gGa>gAa	p.G353E	C20orf26_ENST00000451767.2_Missense_Mutation_p.G353E|C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377306.1_Missense_Mutation_p.G353E|C20orf26_ENST00000377309.2_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	353										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ATCTCCACTGGATATGCACAG	0.532000													17	72					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20344598	20344598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20344598C>T	ENST00000298642.2	+	1	208	c.172C>T	c.(172-174)Cct>Tct	p.P58S		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTACACTCTCCTATGTATTT	0.398000													113	243					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401262	89401262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89401262G>A	ENST00000439576.2	+	12	5820	c.5446G>A	c.(5446-5448)Gtt>Att	p.V1816I	ACAN_ENST00000559004.1_Missense_Mutation_p.V1816I|ACAN_ENST00000561243.1_Missense_Mutation_p.V1816I|ACAN_ENST00000352105.7_Missense_Mutation_p.V1816I	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1816					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCCTGACCTGGTTTCTGGTAC	0.512000													17	46					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8207323	8207323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8207323G>A	ENST00000382521.3	+	3	302	c.232G>A	c.(232-234)Gac>Aac	p.D78N	SH3TC1_ENST00000539824.1_Intron|SH3TC1_ENST00000245105.3_Intron			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	349							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						TTTTTCCAGGGACGCGTCAGT	0.557000													12	42					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204924014	204924014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204924014C>T	ENST00000367172.4	+	7	798	c.470C>T	c.(469-471)cCt>cTt	p.P157L	NFASC_ENST00000404076.1_Missense_Mutation_p.P151L|NFASC_ENST00000513543.1_Missense_Mutation_p.P151L|NFASC_ENST00000367171.4_Missense_Mutation_p.P157L|NFASC_ENST00000403080.1_Missense_Mutation_p.P157L|NFASC_ENST00000339876.6_Missense_Mutation_p.P157L|NFASC_ENST00000539706.1_Missense_Mutation_p.P151L|NFASC_ENST00000404907.1_Missense_Mutation_p.P151L|NFASC_ENST00000360049.4_Missense_Mutation_p.P151L|NFASC_ENST00000367170.4_Missense_Mutation_p.P157L|NFASC_ENST00000401399.1_Missense_Mutation_p.P157L|NFASC_ENST00000367169.4_Missense_Mutation_p.P157L|NFASC_ENST00000338586.6_Missense_Mutation_p.P157L|NFASC_ENST00000338515.6_Missense_Mutation_p.P157L			O94856	NFASC_HUMAN	neurofascin	157	Ig-like C2-type 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GAGGGCGCTCCTTTGACGCTC	0.552000													81	203					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96134679	96134679	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96134679C>T	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		CTGTGCACATCCTACGTTACT	0.478000			T	TRA@	T-ALL								14	67					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262636	140262636	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140262636G>A	ENST00000289272.2	+	1	783	c.783G>A	c.(781-783)gtG>gtA	p.V261V	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.V261V|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACATTAGTGATCAAGCTAA	0.423000													36	114					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56742738	56742738	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56742738G>A	ENST00000314128.4	-	17	1569	c.1546C>T	c.(1546-1548)Cag>Tag	p.Q516*	STAT2_ENST00000556539.1_5'UTR|STAT2_ENST00000557235.1_Nonsense_Mutation_p.Q512*			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	516					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						ATGCTCAGCTGGTCTGAGTTG	0.552000													16	67					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24811049	24811049	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24811049C>T	ENST00000221169.5	-	0	2024							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		tcctcctcctcGGCTTCTCCT	0.532000													6	17					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45844734	45844734	+	Splice_Site	SNP	G	G	A	rs145618288		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45844734G>A	ENST00000397928.1	+	24	3994		c.e24-1		TRPM2_ENST00000397932.2_Splice_Site|TRPM2_ENST00000300482.5_Splice_Site|TRPM2_ENST00000498430.1_Splice_Site|TRPM2_ENST00000300481.9_Splice_Site	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2							integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ATGCCTTCCAGGTGGCCCAGA	0.677000													6	11					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197024862	197024862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197024862G>A	ENST00000367412.1	-	8	1380	c.1337C>T	c.(1336-1338)tCc>tTc	p.S446F		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	446	Sushi 7.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						AACAGGTGGGGATGACCATTT	0.368000													39	73					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71740108	71740108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71740108C>T	ENST00000318442.5	-	5	2200	c.1710G>A	c.(1708-1710)agG>agA	p.R570R		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CGATTCTCCCCCTTCCCAGAC	0.597000													30	49					0	0	1	0	0
TBL2	26608	broad.mit.edu	37	7	72985229	72985229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72985229G>A	ENST00000305632.5	-	7	1193	c.952C>T	c.(952-954)Ccc>Tcc	p.P318S	TBL2_ENST00000459913.1_5'UTR|TBL2_ENST00000432538.1_Missense_Mutation_p.P282S	NM_012453.2	NP_036585.1	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	318										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	19		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGCAAGTAGGGGTCCTGCTTC	0.587000													32	98					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38592977	38592977	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38592977C>T	ENST00000413689.1	-	28	5079	c.4886G>A	c.(4885-4887)cGa>cAa	p.R1629Q	SCN5A_ENST00000423572.2_Missense_Mutation_p.R1628Q|SCN5A_ENST00000425664.1_Missense_Mutation_p.R1611Q|SCN5A_ENST00000455624.2_Missense_Mutation_p.R1596Q|SCN5A_ENST00000450102.2_Missense_Mutation_p.R1575Q|SCN5A_ENST00000449557.2_Missense_Mutation_p.R1575Q|SCN5A_ENST00000414099.2_Missense_Mutation_p.R1611Q|SCN5A_ENST00000451551.2_Missense_Mutation_p.R1575Q|SCN5A_ENST00000333535.4_Missense_Mutation_p.R1629Q|SCN5A_ENST00000443581.1_Missense_Mutation_p.R1628Q	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1629					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCGGCCTATTCGGGCCAGGCG	0.592000													42	94					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20585969	20585969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20585969G>A	ENST00000202677.6	-	15	2030	c.1888C>T	c.(1888-1890)Ctc>Ttc	p.L630F	RALGAPA2_ENST00000495793.1_5'UTR	NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	630					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						CATTCCGTGAGGGAGGACAGC	0.483000													12	42					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20649564	20649564	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20649564C>T	ENST00000428453.1	-	0	2634																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TAATTTCCTTCTTTCCCCATC	0.587000													56	141					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96053623	96053623	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:96053623G>A	ENST00000358812.4	+	5	865		c.e5-1		MANEA_ENST00000474553.1_Splice_Site	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha						post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		TTATTTTCTAGATATGGAAAT	0.348000													16	57					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141525	133141525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133141525G>A	ENST00000388996.4	-	15	3023	c.2603C>T	c.(2602-2604)tCc>tTc	p.S868F	KCNQ3_ENST00000519445.1_Missense_Mutation_p.S856F|KCNQ3_ENST00000521134.1_Missense_Mutation_p.S748F	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	868					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GGGCTTATTGGAAGGGGTCCA	0.532000													6	67					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46202900	46202900	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46202900C>T	ENST00000252934.5	+	10	1500	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L	ATXN10_ENST00000402380.3_Missense_Mutation_p.P63L|ATXN10_ENST00000381061.4_Missense_Mutation_p.P348L	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	412					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		GACAGTAACCCCTGTATCCTT	0.453000													31	86					0	0	1	0	0
SPO11	23626	broad.mit.edu	37	20	55908293	55908293	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:55908293A>C	ENST00000371263.3	+	3	404	c.295A>C	c.(295-297)Aag>Cag	p.K99Q	SPO11_ENST00000371260.4_Missense_Mutation_p.K61Q|SPO11_ENST00000345868.4_Missense_Mutation_p.K61Q	NM_012444.2	NP_036576.1	Q9Y5K1	SPO11_HUMAN	SPO11 meiotic protein covalently bound to DSB	99					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			autonomic_ganglia(1)|breast(3)|large_intestine(4)|lung(8)|skin(2)	18	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			CACCACCAGAAAGATCAAAAG	0.308000								Editing and processing nucleases					8	68					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102480727	102480727	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102480727C>T	ENST00000260228.2	-	4	570	c.558G>A	c.(556-558)cgG>cgA	p.R186R	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	186					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CTAGAGTCCCCCGAGGCCCAT	0.493000													17	45					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63885483	63885483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63885483G>A	ENST00000246841.3	+	2	2787	c.1744G>A	c.(1744-1746)Gag>Aag	p.E582K	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	554					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CCAGGCTGGCGAGCTGCTGAC	0.627000													4	52					0	0	1	0	0
FAM71A	149647	broad.mit.edu	37	1	212799896	212799896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:212799896G>A	ENST00000294829.3	+	1	2108	c.1677G>A	c.(1675-1677)agG>agA	p.R559R	RP11-338C15.5_ENST00000427949.1_RNA	NM_153606.3	NP_705834.2	Q8IYT1	FA71A_HUMAN	family with sequence similarity 71, member A	559										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		TGGCGGAGAGGAGCACCAACG	0.552000													38	101					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63141520	63141520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63141520C>T	ENST00000310969.4	+	3	929	c.661C>T	c.(661-663)Ctt>Ttt	p.L221F	SLC22A9_ENST00000279178.3_Silent_p.I272I			Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	0					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						ACTTTGTGATCTTTCTGACCT	0.428000													9	30					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38539158	38539158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38539158C>T	ENST00000287675.5	+	2	298	c.202C>T	c.(202-204)Cct>Tct	p.P68S	EXOG_ENST00000422077.2_Intron|EXOG_ENST00000358249.2_5'UTR	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	68						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						ATTTGGATTCCCTTTAACTGG	0.393000													31	61					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303861	151303861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151303861C>T	ENST00000370323.4	-	4	548	c.232G>A	c.(232-234)Gat>Aat	p.D78N	MAGEA10_ENST00000244096.3_Missense_Mutation_p.D78N|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	78										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GGTGTCTCATCATCAGCAGAA	0.542000													70	57					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8601239	8601239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8601239C>T	ENST00000338257.8	-	19	2207	c.1940G>A	c.(1939-1941)gGg>gAg	p.G647E		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	647	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GCGTTCGTCCCCACGCCACCG	0.652000													7	86					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6096537	6096537	+	Silent	SNP	C	C	T	rs141850118	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6096537C>T	ENST00000217289.4	-	3	1094	c.306G>A	c.(304-306)ccG>ccA	p.P102P	FERMT1_ENST00000536936.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	102	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TCTTCAAATTCGGCAGACGAA	0.498000													40	90					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039366	11039366	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039366G>A	ENST00000470054.1	-	0	837									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTCACTTCAGAAGACATTTT	0.353000													15	368					0	0	1	0	0
DPPA4	55211	broad.mit.edu	37	3	109049587	109049587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:109049587C>T	ENST00000335658.6	-	5	517	c.463G>A	c.(463-465)Gaa>Aaa	p.E155K	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	155						nucleus	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						AGGGACGTTTCCCCCTTTTCC	0.458000													31	97					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230894	21230894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21230894G>A	ENST00000233242.1	-	26	8973	c.8846C>T	c.(8845-8847)aCc>aTc	p.T2949I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2949					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCCTTCTATGGTGAAACTAAT	0.448000													54	177					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142586780	142586780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:142586780C>T	ENST00000378004.3	+	21	2361	c.2006C>T	c.(2005-2007)cCa>cTa	p.P669L	ARHGAP26_ENST00000274498.4_Missense_Mutation_p.P669L|ARHGAP26_ENST00000486650.1_Intron	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	669	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATCCAAGCCCAACTTCACCC	0.577000													31	116					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26739344	26739344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26739344C>T	ENST00000272371.2	-	5	577	c.451G>A	c.(451-453)Gga>Aga	p.G151R	OTOF_ENST00000403946.3_Missense_Mutation_p.G151R	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	151					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGCAGTCCATCCGTCTCT	0.632000													29	123					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23066136	23066136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23066136C>T	ENST00000246006.4	-	1	841	c.694G>A	c.(694-696)Gag>Aag	p.E232K		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	232					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CTCTGAGTCTCGTCCTTGTCA	0.597000													47	129					0	0	1	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6882289	6882289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6882289C>T	ENST00000419673.2	+	10	1184	c.967C>T	c.(967-969)Cta>Tta	p.L323L	ARHGAP28_ENST00000531294.1_Silent_p.L318L|ARHGAP28_ENST00000418986.1_Silent_p.L323L|ARHGAP28_ENST00000262227.3_Silent_p.L430L|ARHGAP28_ENST00000314319.3_Silent_p.L323L|ARHGAP28_ENST00000383472.4_Silent_p.L482L|ARHGAP28_ENST00000532996.1_Silent_p.L305L|ARHGAP28_ENST00000400091.2_Silent_p.L482L	NM_001010000.2	NP_001010000.1	B4DXL2	B4DXL2_HUMAN	Rho GTPase activating protein 28	305					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				CTTCATCAGTCTAATGGAAAG	0.403000													19	57					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52818464	52818464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52818464G>A	ENST00000273283.2	+	11	1402	c.1378G>A	c.(1378-1380)Gag>Aag	p.E460K	ITIH1_ENST00000537050.1_Missense_Mutation_p.E172K|ITIH1_ENST00000542827.1_Missense_Mutation_p.E460K|ITIH1_ENST00000540715.1_Missense_Mutation_p.E318K	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	460	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GAGAATCTACGAGGACCATGA	0.582000													24	55					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126079218	126079218	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:126079218G>A	ENST00000339582.2	-	11	3490	c.2682C>T	c.(2680-2682)tcC>tcT	p.S894S	GRM8_ENST00000444921.2_Silent_p.S894S|GRM8_ENST00000358373.3_3'UTR			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	894					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TCTTGGTAGAGGAAGCTGTTA	0.289000										HNSCC(24;0.065)			55	122					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8185497	8185497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8185497G>A	ENST00000520004.1	-	5	3059	c.2795C>T	c.(2794-2796)aCc>aTc	p.T932I	SGK223_ENST00000330777.4_Missense_Mutation_p.T932I			Q86YV5	SG223_HUMAN		932							ATP binding|non-membrane spanning protein tyrosine kinase activity										CTGAAGCTGGGTGCTCCCGGT	0.657000													11	47					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37670821	37670821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37670821G>A	ENST00000264741.5	+	16	2089	c.1833G>A	c.(1831-1833)aaG>aaA	p.K611K	ITGA9_ENST00000422441.1_Silent_p.K611K	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	611					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TTGCCCAAAAGAATCAGGTCA	0.532000													8	24					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74361203	74361203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:74361203G>A	ENST00000377044.4	-	3	925	c.386C>T	c.(385-387)tCt>tTt	p.S129F	TMEM2_ENST00000377066.5_Missense_Mutation_p.S129F	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	129	G8.					integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TTGCTTTGCAGAATCTTGTCC	0.433000													10	78					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55615307	55615307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55615307C>T	ENST00000326258.1	+	1	499	c.499C>T	c.(499-501)Cct>Tct	p.P167S		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						GATGGCCCTTCCTTTCTGTGG	0.478000													34	96					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6594233	6594233	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6594233C>T	ENST00000433363.2	-	10	1535	c.1302G>A	c.(1300-1302)ggG>ggA	p.G434G	SLC13A5_ENST00000381074.4_Silent_p.G391G|SLC13A5_ENST00000573648.1_Silent_p.G434G|SLC13A5_ENST00000293800.6_Silent_p.G417G	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	434						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						CCATCTGCTTCCCCATCCACA	0.627000													41	50					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887096	9887096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:9887096G>A	ENST00000306084.6	+	2	819	c.620G>A	c.(619-621)gGt>gAt	p.G207D	TXNDC2_ENST00000357775.4_Missense_Mutation_p.G140D|TXNDC2_ENST00000536353.2_Intron	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	207	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						CCCAAAGAGGGTGACATCCCC	0.567000													38	187					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18753478	18753478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18753478C>T	ENST00000380548.4	+	16	2528	c.2189C>T	c.(2188-2190)cCa>cTa	p.P730L		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	730						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		AATTGCCCCCCAGCCTGGTAC	0.512000													6	15					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167056366	167056366	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167056366G>A	ENST00000375387.4	-	27	5126	c.4786C>T	c.(4786-4788)Cta>Tta	p.L1596L	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Silent_p.L1584L|SCN9A_ENST00000409435.1_Silent_p.L1595L|SCN9A_ENST00000303354.6_Silent_p.L1596L			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1595						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AAATCAGCTAGAAACATACCT	0.378000													34	87					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143679	55143679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55143679C>T	ENST00000396331.1	+	6	1009	c.652C>T	c.(652-654)Ctg>Ttg	p.L218L	LILRB1_ENST00000427581.2_Silent_p.L254L|LILRB1_ENST00000434867.2_Silent_p.L218L|LILRB1_ENST00000396315.1_Silent_p.L218L|LILRB1_ENST00000448689.1_Silent_p.L218L|LILRB1_ENST00000418536.2_Silent_p.L218L|LILRB1_ENST00000396321.2_Silent_p.L218L|LILRB1_ENST00000324602.7_Silent_p.L218L|LILRB1_ENST00000396317.1_Silent_p.L218L|LILRB1_ENST00000396332.4_Silent_p.L218L|LILRB1_ENST00000396327.3_Silent_p.L218L	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	218	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCTGGAGCTCCTGGTCCTAGG	0.592000										HNSCC(37;0.09)			48	147					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60753853	60753853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60753853G>A	ENST00000303375.5	+	11	2197	c.1795G>A	c.(1795-1797)Gat>Aat	p.D599N		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	599	C-type lectin 3.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GCTCAGTGGGGATGAAGTCAT	0.617000													43	97					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174768	51174768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51174768C>T	ENST00000440970.1	-	2	1505	c.1074G>A	c.(1072-1074)gcG>gcA	p.A358A	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.A455A|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	455					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CAAAGACCTTCGCGCAGAACC	0.512000													44	82					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602760	96602760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96602760C>T	ENST00000371321.3	+	7	1210	c.1128C>T	c.(1126-1128)ttC>ttT	p.F376F	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	376					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	ACGTTAAATTCAGAAACTACC	0.473000													37	138					0	0	1	0	0
IGKV3D-11	28876	broad.mit.edu	37	2	90212209	90212209	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90212209G>A	ENST00000390277.2	+	0	398																											CCTAGAGCCTGAAGATTTTGC	0.502000													39	72					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111748180	111748180	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111748180G>C	ENST00000261726.6	+	15	1748	c.1594G>C	c.(1594-1596)Ggt>Cgt	p.G532R		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	532	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GCCACTGGGCGGTCCTGAGCC	0.741000													3	20					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161019326	161019326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161019326C>T	ENST00000368013.3	-	11	1894	c.1574G>A	c.(1573-1575)gGg>gAg	p.G525E	ARHGAP30_ENST00000368015.1_Missense_Mutation_p.G348E|ARHGAP30_ENST00000368016.3_Missense_Mutation_p.G525E	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	525					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ATCCTCTGCCCCCACCCACTC	0.647000													32	110					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143049018	143049018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143049018G>A	ENST00000343257.2	+	23	3014	c.2927G>A	c.(2926-2928)cGa>cAa	p.R976Q		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	976					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CCCAGCCTGCGATCCACAGAC	0.617000													26	94					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107491536	107491536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:107491536C>T	ENST00000415149.2	+	11	1295	c.968C>T	c.(967-969)tCc>tTc	p.S323F	BBX_ENST00000325805.8_Missense_Mutation_p.S323F|BBX_ENST00000406780.1_Missense_Mutation_p.S323F|BBX_ENST00000402543.1_Missense_Mutation_p.S323F|BBX_ENST00000416476.2_Intron	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	323					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GCAAAAGAATCCGATGGTGGA	0.348000													14	78					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58475249	58475249	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58475249G>A	ENST00000357552.3	-	18	1573	c.1348C>T	c.(1348-1350)Cct>Tct	p.P450S	SYCP2_ENST00000371001.2_Missense_Mutation_p.P450S			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	450					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TATTTTGAAGGTTTAGCAAAT	0.358000													20	62					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96792160	96792160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96792160G>A	ENST00000359933.4	-	15	3156	c.2263C>T	c.(2263-2265)Cgc>Tgc	p.R755C		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	755										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		ATTGGGAAGCGAACAGAAAGG	0.413000													11	103					0	0	1	0	0
PXMP2	5827	broad.mit.edu	37	12	133272542	133272542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:133272542C>T	ENST00000317479.3	+	3	374	c.309C>T	c.(307-309)ccC>ccT	p.P103P	RP13-672B3.2_ENST00000537262.1_Intron|PXMP2_ENST00000539093.1_Intron|PXMP2_ENST00000543589.1_Intron|PXMP2_ENST00000545677.1_Intron|PXMP2_ENST00000428960.2_Silent_p.P10P	NM_018663.1	NP_061133.1	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	103						integral to membrane|peroxisomal membrane	protein binding			large_intestine(1)|liver(2)|lung(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		CTGAGGTCCCCCTGGCAGGGC	0.572000													6	51					0	0	1	0	0
TDGF1P3	6998	broad.mit.edu	37	X	109764975	109764975	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:109764975C>T	ENST00000602699.1	+	0	1436					NR_002718.2																						ATGCAAATTTCATGACCCGTA	0.343000													15	22					0	0	1	0	0
POTEB	100996331	broad.mit.edu	37	15	22062320	22062320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22062320G>A	ENST00000439682.1	-	9	1345	c.1294C>T	c.(1294-1296)Cac>Tac	p.H432Y		NM_001277304.1	NP_001264233.1	Q6S5H4	POTEB_HUMAN	POTE ankyrin domain family, member B	469										endometrium(2)|kidney(8)|lung(4)	14						GCTCACCTGTGATACTCTTCA	0.373000													36	32					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3428168	3428168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3428168G>A	ENST00000356575.4	-	9	1286	c.1060C>T	c.(1060-1062)Ctg>Ttg	p.L354L	MEGF6_ENST00000294599.4_Silent_p.L249L	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	354	EGF-like 6.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CATGTGCACAGGGGCCCAGCA	0.642000													22	63					0	0	1	0	0
ENO1	2023	broad.mit.edu	37	1	8924024	8924024	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8924024G>A	ENST00000234590.4	-	9	1112	c.993C>T	c.(991-993)gcC>gcT	p.A331A		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	331					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		TCTCGTTCACGGCCTTGGCGA	0.562000													79	212					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	132826487	132826487	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:132826487A>G	ENST00000370818.3	-	5	1647	c.1202T>C	c.(1201-1203)tTc>tCc	p.F401S	GPC3_ENST00000394299.2_Missense_Mutation_p.F424S|GPC3_ENST00000543339.1_Missense_Mutation_p.F347S	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	401						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					AGCACTATAGAAGCTGATGAA	0.413000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				41	31					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38793958	38793958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38793958G>A	ENST00000359357.3	+	27	3477	c.3223G>A	c.(3223-3225)Gag>Aag	p.E1075K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E1292K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E1075K					dynein, axonemal, heavy chain 8									p.E1075Q(1)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTTATCCATCGAGGCCAAGGC	0.333000													11	34					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532026	84532026	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84532026C>T	ENST00000527857.1	+	0	2048					NR_026851.1																						GGTCCATGTTCCCATCTCCAT	0.478000													9	57					0	0	1	0	0
APOA5	116519	broad.mit.edu	37	11	116661443	116661443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:116661443C>T	ENST00000542499.1	-	4	574	c.502G>A	c.(502-504)Gag>Aag	p.E168K	APOA5_ENST00000227665.4_Missense_Mutation_p.E168K	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	168					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		GCCCAAGCCTCGTCCACGCCC	0.667000													20	53					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37770944	37770944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37770944C>T	ENST00000402918.1	-	3	1416	c.631G>A	c.(631-633)Gac>Aac	p.D211N	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Missense_Mutation_p.D211N	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	211	LRRCT.					cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					TGCAGGCGGTCGTAGTTCTTG	0.632000													11	21					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89662818	89662818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89662818C>T	ENST00000355754.6	-	2	307	c.210G>A	c.(208-210)atG>atA	p.M70I		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	70						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		CAAGACGATTCATGAGATAGG	0.488000													19	56					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36778713	36778713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36778713G>A	ENST00000416516.2	-	2	1928	c.1438C>T	c.(1438-1440)Ccg>Tcg	p.P480S		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	480	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						AGGTTTTCCGGCTTGAGGTCC	0.453000													12	41					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27789904	27789904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27789904C>T	ENST00000261588.4	+	28	4830	c.4811C>T	c.(4810-4812)cCc>cTc	p.P1604L		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1604										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GCCTTACGTCCCAAAACCTGC	0.597000													25	102					0	0	1	0	0
PRL	5617	broad.mit.edu	37	6	22294766	22294766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:22294766C>T	ENST00000306482.1	-	2	594	c.76G>A	c.(76-78)Gtg>Atg	p.V26M	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	26					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					AAGGGGGCCACGCTCTGGCAC	0.592000													4	26					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28478684	28478684	+	Missense_Mutation	SNP	G	G	A	rs143710331		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28478684G>A	ENST00000261609.7	-	29	4483	c.4375C>T	c.(4375-4377)Cat>Tat	p.H1459Y		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1459					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCACCTGCATGAACTAAAGAT	0.418000													35	103					0	0	1	0	0
TPST2	8459	broad.mit.edu	37	22	26937530	26937530	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26937530G>A	ENST00000338754.4	-	3	337	c.67C>T	c.(67-69)Cag>Tag	p.Q23*	TPST2_ENST00000403880.1_Nonsense_Mutation_p.Q23*|TPST2_ENST00000398110.2_Nonsense_Mutation_p.Q23*	NM_003595.3	NP_003586.3	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	23					peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)|large_intestine(1)|lung(5)	7						TGTCCCAGCTGAACCGCCAGC	0.741000													3	18					0	0	1	0	0
NPTX1	4884	broad.mit.edu	37	17	78445594	78445594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78445594C>T	ENST00000306773.4	-	4	1172	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K		NM_002522.3	NP_002513.2	Q15818	NPTX1_HUMAN	neuronal pentraxin I	339	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)	11	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GCCAAGTTCTCGCCACTGCCA	0.632000													23	49					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99582506	99582506	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:99582506G>A	ENST00000376460.1	-	3	329	c.249C>T	c.(247-249)gcC>gcT	p.A83A	DOCK9_ENST00000442173.1_Silent_p.A83A|DOCK9_ENST00000339416.2_Silent_p.A84A|DOCK9_ENST00000448493.2_Silent_p.A95A	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	84	Interaction with activated CDC42 (By similarity).				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTCTCAGGATGGCCGTCTGGA	0.552000													6	11					0	0	1	0	0
IL15RA	3601	broad.mit.edu	37	10	6008179	6008179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6008179C>T	ENST00000525219.2	-	2	398	c.104G>A	c.(103-105)aGc>aAc	p.S35N	IL15RA_ENST00000397250.2_Intron|IL15RA_ENST00000528354.1_Missense_Mutation_p.S71N|IL15RA_ENST00000397251.3_Intron|IL15RA_ENST00000397248.2_Missense_Mutation_p.S35N|IL15RA_ENST00000379971.1_Intron|IL15RA_ENST00000379977.3_Missense_Mutation_p.S71N|IL15RA_ENST00000530685.1_Missense_Mutation_p.S71N|IL15RA_ENST00000397255.3_Missense_Mutation_p.S71N|IL15RA_ENST00000534292.1_5'UTR	NM_001243539.1	NP_001230468.1	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha	71	Sushi.				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5						CTCCGTCAGGCTGGACGTGCC	0.552000													17	35					0	0	1	0	0
MAP3K15	389840	broad.mit.edu	37	X	19410551	19410551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:19410551C>T	ENST00000338883.4	-	17	2234	c.2235G>A	c.(2233-2235)atG>atA	p.M745I	MAP3K15_ENST00000359173.3_Missense_Mutation_p.M180I|MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Missense_Mutation_p.M577I	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	745	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					TCGGTTCCTTCATCGGCCCCC	0.433000													64	34					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18075548	18075548	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18075548C>T	ENST00000205890.5	+	64	10632	c.10294C>T	c.(10294-10296)Cct>Tct	p.P3432S	MYO15A_ENST00000451725.2_Silent_p.P225P|MYO15A_ENST00000418233.3_Missense_Mutation_p.P696S	NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	3432	FERM.|Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TGTGCCAGCCCCTTGCATCCT	0.587000													27	37					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582564	136582564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136582564G>A	ENST00000531224.1	-	12	2848	c.2596C>T	c.(2596-2598)Cgt>Tgt	p.R866C	BCLAF1_ENST00000392348.2_Missense_Mutation_p.R815C|BCLAF1_ENST00000530767.1_Missense_Mutation_p.R693C|BCLAF1_ENST00000031135.9_Missense_Mutation_p.R84C|BCLAF1_ENST00000527759.1_Missense_Mutation_p.R864C|BCLAF1_ENST00000527536.1_Missense_Mutation_p.R817C|BCLAF1_ENST00000353331.4_Missense_Mutation_p.R815C|BCLAF1_ENST00000529917.1_5'UTR	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	866					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAAGTACCACGACCTCTTCCT	0.408000													55	310					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36169514	36169514	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:36169514C>T	ENST00000335119.2	+	1	126	c.15C>T	c.(13-15)ttC>ttT	p.F5F		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	5					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			AATTGGAATTCACGGAGAAAA	0.493000													12	40					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74565190	74565190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74565190G>A	ENST00000321288.5	+	9	1326	c.1326G>A	c.(1324-1326)atG>atA	p.M442I	CCDC33_ENST00000398814.3_Missense_Mutation_p.M239I			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	442							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CGTCCATGATGAACTTTGACG	0.602000													24	103					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93148220	93148220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93148220G>A	ENST00000298050.3	+	13	1678	c.1578G>A	c.(1576-1578)tcG>tcA	p.S526S	CCDC67_ENST00000525646.1_Silent_p.S268S	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	526										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TGCCACCTTCGACATTTCAAG	0.413000													23	84					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	169995191	169995191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169995191C>T	ENST00000263816.3	-	75	13699	c.13414G>A	c.(13414-13416)Gaa>Aaa	p.E4472K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4472					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTCCCATTTTCAGAGGGCTTG	0.418000													12	68					0	0	1	0	0
FBXL12	54850	broad.mit.edu	37	19	9922101	9922101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9922101G>A	ENST00000247977.4	-	3	693	c.452C>T	c.(451-453)cCc>cTc	p.P151L	FBXL12_ENST00000585379.1_Missense_Mutation_p.P98L|FBXL12_ENST00000586651.1_3'UTR|FBXL12_ENST00000589626.1_3'UTR|FBXL12_ENST00000592067.1_3'UTR|FBXL12_ENST00000591009.1_Missense_Mutation_p.P98L|FBXL12_ENST00000588922.1_3'UTR	NM_017703.1	NP_060173.1	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	151							protein binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(2)	10						TTCAAGCAGGGGCAGCACGGT	0.677000													24	66					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57860961	57860961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:57860961C>T	ENST00000381227.1	+	6	918	c.505C>T	c.(505-507)Cgt>Tgt	p.R169C	POLR2B_ENST00000441246.2_Missense_Mutation_p.R162C|POLR2B_ENST00000431623.2_Missense_Mutation_p.R94C|POLR2B_ENST00000314595.5_Missense_Mutation_p.R169C			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	169					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					CTTGACAGATCGTGATCTTTG	0.338000													41	78					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841197	13841197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13841197C>T	ENST00000265104.4	-	34	5631	c.5527G>A	c.(5527-5529)Gaa>Aaa	p.E1843K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1843	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGGGCTTCTTCTGAATCCCGT	0.348000									Kartagener syndrome				31	57					0	0	1	0	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293708	71293708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71293708G>A	ENST00000398530.1	-	1	213	c.176C>T	c.(175-177)tCc>tTc	p.S59F	AP000867.1_ENST00000343767.3_Intron|KRTAP5-11_ENST00000526239.1_Intron	NM_001005405.2	NP_001005405.1	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	59	6 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						GCCCCCACAGGAGCCACAGCT	0.632000													18	261					0	0	1	0	0
SPRY1	10252	broad.mit.edu	37	4	124322981	124322981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:124322981G>A	ENST00000394339.2	+	2	575	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	SPRY1_ENST00000339241.1_Missense_Mutation_p.E79K	NM_001258039.1|NM_005841.2	NP_001244968.1|NP_005832.1	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	79					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				NS(1)|large_intestine(4)|lung(2)|ovary(1)|skin(3)	11						AAGGACTCATGAAATCATACC	0.478000													37	96					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13361447	13361447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13361447G>A	ENST00000254508.5	-	37	5281	c.5199C>T	c.(5197-5199)ttC>ttT	p.F1733F		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1733					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TCTCCTTTGCGAATGCCAGCA	0.627000													17	58					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39008179	39008179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39008179C>T	ENST00000355481.4	+	66	9997	c.9866C>T	c.(9865-9867)cCc>cTc	p.P3289L	RYR1_ENST00000360985.3_Missense_Mutation_p.P3289L|RYR1_ENST00000359596.3_Missense_Mutation_p.P3289L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3289					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAGCGCGGGCCCGAGGCACCC	0.667000													20	31					0	0	1	0	0
KCNG4	93107	broad.mit.edu	37	16	84256226	84256226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84256226G>A	ENST00000308251.4	-	3	1225	c.1157C>T	c.(1156-1158)tCc>tTc	p.S386F		NM_172347.2	NP_758857.1	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G, member 4	386						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	31						GACCAAAGGGGAGAAGAGGGT	0.642000													3	28					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104516006	104516006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104516006G>A	ENST00000409874.4	+	35	4084	c.4036G>A	c.(4036-4038)Gag>Aag	p.E1346K	TDRD9_ENST00000339063.5_Missense_Mutation_p.E1155K	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	1346					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				AAAGCCCTACGAGTGGAATCA	0.478000													5	13					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82834003	82834003	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82834003G>A	ENST00000265077.3	+	8	5746	c.5181G>A	c.(5179-5181)gaG>gaA	p.E1727E	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.E740E|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1727	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAAGGAAGGAGGAGGAGGGAA	0.403000													37	93					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4245738	4245738	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4245738C>T	ENST00000399609.3	-	5	438	c.426G>A	c.(424-426)aaG>aaA	p.K142K	SRL_ENST00000537996.1_Silent_p.K100K	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	601	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						TGGTTTTCAGCTTAGGCCCAT	0.542000													5	29					0	0	1	0	0
FAM122C	159091	broad.mit.edu	37	X	133981471	133981471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:133981471C>T	ENST00000445123.1	+	8	1445	c.149C>T	c.(148-150)tCc>tTc	p.S50F	FAM122C_ENST00000370785.3_Missense_Mutation_p.S135F|FAM122C_ENST00000370784.4_Intron			Q6P4D5	F222C_HUMAN	family with sequence similarity 122C	0										endometrium(2)|kidney(1)|lung(2)	5	Acute lymphoblastic leukemia(192;0.000127)					ACTCCAGTATCCTCAATGGCT	0.368000													33	32					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39817345	39817345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39817345C>T	ENST00000442448.1	-	4	510	c.239G>A	c.(238-240)aGc>aAc	p.S80N	ERG_ENST00000398910.1_Missense_Mutation_p.S80N|ERG_ENST00000398911.1_Missense_Mutation_p.S80N|ERG_ENST00000429727.2_Missense_Mutation_p.S73N|ERG_ENST00000398905.1_Missense_Mutation_p.S73N|ERG_ENST00000417133.2_Missense_Mutation_p.S80N|ERG_ENST00000288319.7_Missense_Mutation_p.S73N|ERG_ENST00000398897.1_Intron|ERG_ENST00000453032.2_Intron|ERG_ENST00000398919.2_Missense_Mutation_p.S80N|ERG_ENST00000398907.1_Missense_Mutation_p.S73N	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	80					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				ATTCACCTGGCTAGGGTTACA	0.527000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								13	35					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6245348	6245348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6245348G>A	ENST00000265978.4	-	3	627	c.269C>T	c.(268-270)cCc>cTc	p.P90L	FAM160A2_ENST00000449352.2_Missense_Mutation_p.P90L|FAM160A2_ENST00000524416.1_Missense_Mutation_p.P90L	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	90					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGGGCCTGTGGGGGCCGAGGG	0.627000													13	31					0	0	1	0	0
KMO	8564	broad.mit.edu	37	1	241725561	241725561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:241725561C>T	ENST00000366559.4	+	7	855	c.544C>T	c.(544-546)Cgc>Tgc	p.R182C	KMO_ENST00000366557.4_Missense_Mutation_p.R182C|KMO_ENST00000366558.3_Missense_Mutation_p.R182C|KMO_ENST00000484628.1_3'UTR	NM_003679.4	NP_003670.2	O15229	KMO_HUMAN	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	182					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GAAGAAACCTCGCTTTGATTA	0.438000													30	120					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211093356	211093356	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:211093356C>T	ENST00000367007.4	-	7	1176	c.1007G>A	c.(1006-1008)cGa>cAa	p.R336Q	KCNH1_ENST00000271751.4_Missense_Mutation_p.R363Q	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	363					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity	p.R363Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ACGGGCCACTCGCCCAAGACG	0.562000													21	111					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41159280	41159280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41159280C>T	ENST00000263413.3	-	12	2024	c.1760G>A	c.(1759-1761)cGa>cAa	p.R587Q	C6_ENST00000337836.5_Missense_Mutation_p.R587Q	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	587	TSP type-1 3.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ATTGCATTCTCGGGTTCTCGA	0.493000													32	95					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81648681	81648681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81648681G>A	ENST00000548058.1	+	16	2951	c.2041G>A	c.(2041-2043)Gaa>Aaa	p.E681K	ACSS3_ENST00000548324.1_Missense_Mutation_p.E363K|ACSS3_ENST00000261206.3_Missense_Mutation_p.E680K			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	681						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						CCACGTAGAAGAAATGCTGAA	0.308000													27	89					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57180319	57180319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:57180319C>T	ENST00000504228.1	+	6	756	c.651C>T	c.(649-651)tcC>tcT	p.S217S	KIAA1211_ENST00000541073.1_Silent_p.S210S|KIAA1211_ENST00000264229.6_Silent_p.S217S			Q6ZU35	K1211_HUMAN	KIAA1211	217	Glu-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CGCTGGATTCCGAGGAAGAGA	0.607000													10	34					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123908902	123908902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123908902C>T	ENST00000330487.5	-	1	815	c.807G>A	c.(805-807)ggG>ggA	p.G269G		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CGGCCACAACCCCATGCAAGG	0.512000													29	64					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50413309	50413309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50413309G>A	ENST00000435965.1	-	20	1949	c.1776C>T	c.(1774-1776)atC>atT	p.I592I	CACNA2D2_ENST00000423994.2_Silent_p.I592I|CACNA2D2_ENST00000429770.1_Silent_p.I592I|CACNA2D2_ENST00000424201.2_Silent_p.I592I|CACNA2D2_ENST00000266039.3_Silent_p.I592I|CACNA2D2_ENST00000479441.1_Silent_p.I592I|CACNA2D2_ENST00000395083.1_Silent_p.I592I|CACNA2D2_ENST00000360963.3_Silent_p.I523I			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	592					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TGCTCCGACGGATCTGGAAGG	0.592000													9	94					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202185	248202185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248202185C>T	ENST00000366479.2	+	1	712	c.616C>T	c.(616-618)Ctt>Ttt	p.L206F	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CACCATCTTTCTTGTGCTTCC	0.478000													28	255					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178562106	178562106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:178562106G>A	ENST00000286063.5	-	15	2616	c.2299C>T	c.(2299-2301)Ctt>Ttt	p.L767F	PDE11A_ENST00000358450.4_Missense_Mutation_p.L517F|PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000449286.2_Missense_Mutation_p.L409F|PDE11A_ENST00000409504.1_Missense_Mutation_p.L409F|PDE11A_ENST00000389683.3_Missense_Mutation_p.L323F	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	767	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGCTTCAAAAGCTGCATAAGG	0.383000									Primary Pigmented Nodular Adrenocortical Disease, Familial				15	90					0	0	1	0	0
OR4F15	390649	broad.mit.edu	37	15	102358832	102358832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:102358832C>T	ENST00000332238.4	+	1	467	c.443C>T	c.(442-444)tCc>tTc	p.S148F		NM_001001674.1	NP_001001674.1	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F, member 15	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(10)	19	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTAGCCACTTCCTCTATCATT	0.403000													82	261					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68643118	68643118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68643118G>A	ENST00000423218.2	-	9	992	c.897C>T	c.(895-897)gtC>gtT	p.V299V	ITGA11_ENST00000315757.7_Silent_p.V299V			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	299	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	AGTAGCCCAGGACCTGCCAGG	0.527000													49	71					0	0	1	0	0
KLHL26	55295	broad.mit.edu	37	19	18775224	18775224	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18775224C>T	ENST00000300976.4	+	2	327	c.237C>T	c.(235-237)gtC>gtT	p.V79V	KLHL26_ENST00000595182.1_Silent_p.V79V|KLHL26_ENST00000599006.1_Silent_p.V79V|KLHL26_ENST00000596843.1_3'UTR	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	79	BTB.									breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						CACACAAGGTCGTCCTGGCTG	0.642000													25	122					0	0	1	0	0
KLK5	25818	broad.mit.edu	37	19	51452325	51452325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51452325C>T	ENST00000336334.3	-	4	734	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K	KLK5_ENST00000391809.2_Missense_Mutation_p.E128K|KLK5_ENST00000593428.1_Missense_Mutation_p.E128K	NM_012427.4	NP_036559.1	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5	128	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			NS(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		TGCCCAGATTCATAAACTGGT	0.542000													38	109					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24538596	24538596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24538596G>A	ENST00000342740.5	+	40	4256	c.4102G>A	c.(4102-4104)Gag>Aag	p.E1368K	LRRC16B_ENST00000334420.7_Missense_Mutation_p.E421K	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1368										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		AGGAACCAGTGAGCCAGGAAC	0.627000													29	44					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97484836	97484836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:97484836C>T	ENST00000376705.2	+	2	824	c.800C>T	c.(799-801)tCt>tTt	p.S267F		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	267						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					TGGAAAACCTCTCTTCATATG	0.507000													16	45					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48764779	48764779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48764779G>A	ENST00000316623.5	-	35	4760	c.4305C>T	c.(4303-4305)ttC>ttT	p.F1435F		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1435	EGF-like 24; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CACTGGGCACGAAGCCCATGT	0.522000													58	116					0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173351826	173351826	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:173351826A>T	ENST00000375221.2	+	15	2250	c.2047A>T	c.(2047-2049)Acc>Tcc	p.T683S	ITGA6_ENST00000343713.4_Missense_Mutation_p.T639S|ITGA6_ENST00000264106.6_Missense_Mutation_p.T683S|ITGA6_ENST00000409532.1_Missense_Mutation_p.T525S|ITGA6_ENST00000264107.7_Missense_Mutation_p.T644S|ITGA6_ENST00000409080.1_Missense_Mutation_p.T644S|AC093818.1_ENST00000442417.1_RNA			P23229	ITA6_HUMAN	integrin, alpha 6	683					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TAAATTTTGCACCCGAGAAGG	0.358000													11	45					0	0	1	0	0
ASS1	445	broad.mit.edu	37	9	133339513	133339513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133339513C>T	ENST00000372394.1	+	6	860	c.379C>T	c.(379-381)Cgg>Tgg	p.R127W	ASS1_ENST00000352480.5_Missense_Mutation_p.R127W|ASS1_ENST00000372393.3_Missense_Mutation_p.R127W			P00966	ASSY_HUMAN	argininosuccinate synthase 1	127			R -> Q (in CTLN1).|R -> W (in CTLN1; severe clinical course).		arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	17				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	CGATCAGGTCCGGTTTGAGCT	0.602000													10	64					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19634676	19634676	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19634676G>A	ENST00000235835.3	-	3	588	c.567C>T	c.(565-567)ggC>ggT	p.G189G		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	189					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGATCCAGCCATTGCTCT	0.612000													26	71					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6752821	6752821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6752821G>A	ENST00000229243.2	-	6	1054	c.961C>T	c.(961-963)Cac>Tac	p.H321Y	ACRBP_ENST00000414226.2_Missense_Mutation_p.H288Y|ACRBP_ENST00000542357.1_5'UTR	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	321						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						GCCTCTGTGTGGGGCAGCTGC	0.587000													30	87					0	0	1	0	0
GSTM5	2949	broad.mit.edu	37	1	110254965	110254965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110254965C>T	ENST00000369812.5	+	1	102	c.31C>T	c.(31-33)Cgt>Tgt	p.R11C	GSTM5_ENST00000369813.1_5'UTR|GSTM5_ENST00000256593.3_Missense_Mutation_p.R11C			P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	11	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity	p.R11C(1)		NS(1)|central_nervous_system(6)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	21		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	CTGGGACATCCGTGGGGTAAG	0.637000													19	221					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4150369	4150369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4150369G>A	ENST00000404826.2	+	23	3538	c.3399G>A	c.(3397-3399)ctG>ctA	p.L1133L	SDK1_ENST00000389531.3_Silent_p.L1133L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1133	Fibronectin type-III 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCAGATGCTGGAGATCCCAA	0.557000													23	40					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021113	5021113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5021113C>T	ENST00000382545.3	+	2	1676	c.569C>T	c.(568-570)cCc>cTc	p.P190L	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	190					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAGACGCTCCCCGAGCTGAAG	0.572000													23	63					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4229251	4229251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:4229251G>A	ENST00000379453.4	-	1	470	c.354C>T	c.(352-354)atC>atT	p.I118I		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	118					cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	CCACTGAGAGGATGACAAGCA	0.652000													7	32					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152544005	152544005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152544005C>T	ENST00000427231.2	-	27	2767	c.2565G>A	c.(2563-2565)atG>atA	p.M855I	NEB_ENST00000409198.1_Missense_Mutation_p.M855I|NEB_ENST00000397345.3_Missense_Mutation_p.M855I|NEB_ENST00000604864.1_Missense_Mutation_p.M855I|NEB_ENST00000172853.10_Missense_Mutation_p.M855I|NEB_ENST00000603639.1_Missense_Mutation_p.M855I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	855					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGGCTCCAATCATTTTCCCTT	0.458000													19	173					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98084132	98084132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98084132G>A	ENST00000419175.1	+	6	1030	c.860G>A	c.(859-861)cGa>cAa	p.R287Q	DNTT_ENST00000371174.2_Missense_Mutation_p.R287Q	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	287	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AAATTTACACGAATGCAGAAA	0.453000													30	104					0	0	1	0	0
CXCL5	6374	broad.mit.edu	37	4	74863807	74863807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74863807G>A	ENST00000296027.4	-	3	445	c.248C>T	c.(247-249)tCc>tTc	p.S83F		NM_002994.3	NP_002985.1	P42830	CXCL5_HUMAN	chemokine (C-X-C motif) ligand 5	83					cell-cell signaling|chemotaxis|immune response|positive regulation of cell proliferation|signal transduction	extracellular space	chemokine activity			endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(1)	9	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			GTTCTTCAGGGAGGCTCTGAA	0.453000													29	93					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100126602	100126602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100126602C>T	ENST00000524871.1	+	17	2406	c.2116C>T	c.(2116-2118)Ctt>Ttt	p.L706F	CNTN5_ENST00000279463.3_Missense_Mutation_p.L706F|CNTN5_ENST00000528682.1_Missense_Mutation_p.L706F|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Missense_Mutation_p.L706F|CNTN5_ENST00000418526.2_Missense_Mutation_p.L632F	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	706	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTCCTACAACCTTCAAGCTCG	0.502000													28	50					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87235216	87235216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87235216C>T	ENST00000297524.3	-	2	905	c.802G>A	c.(802-804)Gaa>Aaa	p.E268K	SLC7A13_ENST00000419776.2_Missense_Mutation_p.E259K|SLC7A13_ENST00000520624.1_5'UTR	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	268						integral to membrane	amino acid transmembrane transporter activity	p.E268K(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						GAGAGAATTTCCCTGGGTGTC	0.383000													35	102					0	0	1	0	0
NPTX2	4885	broad.mit.edu	37	7	98249169	98249169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98249169G>A	ENST00000265634.3	+	2	806	c.641G>A	c.(640-642)cGa>cAa	p.R214Q		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	214					synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GAGCTGGAGCGAGGTGTGTGC	0.587000													4	29					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34493208	34493208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34493208C>T	ENST00000242317.4	+	9	869	c.698C>T	c.(697-699)gCc>gTc	p.A233V	DNAI1_ENST00000488369.1_3'UTR	NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	233					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		ATCTATGATGCCTATGTAGAG	0.453000									Kartagener syndrome				16	91					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156276982	156276982	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156276982C>T	ENST00000311277.4	-	9	1439	c.1176G>A	c.(1174-1176)tcG>tcA	p.S392S	AC097467.2_ENST00000417474.1_RNA|MAP9_ENST00000515654.1_Silent_p.S368S|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000601977.1_RNA|AC097467.2_ENST00000593387.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	392					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		AGGTAGTTGTCGATGGAGTTC	0.348000													8	50					0	0	1	0	0
MIR527	574497	broad.mit.edu	37	19	54257294	54257294	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54257294G>A	ENST00000385244.1	+	0	23					NR_030219.1																						ACTGCAAAGGGAAGCCCTTTC	0.418000													25	189					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134896036	134896036	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134896036C>T	ENST00000607359.1	+	6	1122	c.1122C>T	c.(1120-1122)ttC>ttT	p.F374F				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CTCCTGCCTTCTTTCAATACC	0.587000													7	15					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92616397	92616397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92616397G>A	ENST00000298047.6	+	23	12792	c.12775G>A	c.(12775-12777)Gag>Aag	p.E4259K	FAT3_ENST00000533797.1_Missense_Mutation_p.E594K|FAT3_ENST00000409404.2_Missense_Mutation_p.E4259K|FAT3_ENST00000525166.1_Missense_Mutation_p.E4109K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4259					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.E4259K(2)|p.E834K(1)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTGGGAGGCGAGCACCAGGA	0.682000										TCGA Ovarian(4;0.039)			50	161					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20337703	20337703	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20337703G>A	ENST00000302555.5	-	2	200	c.51C>T	c.(49-51)gcC>gcT	p.A17A	GP2_ENST00000381360.5_Silent_p.A17A|GP2_ENST00000381362.4_Silent_p.A17A|GP2_ENST00000341642.5_Silent_p.A17A			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	17						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGGAGACCAAGGCCAGCCACA	0.532000													18	46					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121420752	121420752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121420752C>T	ENST00000260197.7	+	15	2264	c.2135C>T	c.(2134-2136)cCt>cTt	p.P712L		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	712					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TCATACTCCCCTCCTGTGCCT	0.488000													30	101					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578102	9578102	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9578102C>T	ENST00000301480.4	-	10	1734	c.1521G>A	c.(1519-1521)ttG>ttA	p.L507L		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TGTGAGTTCTCAAATGAGCAA	0.408000													43	102					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21866051	21866051	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21866051C>G	ENST00000399982.2	-	26	5046	c.4982G>C	c.(4981-4983)gGc>gCc	p.G1661A	CHD8_ENST00000557364.1_Missense_Mutation_p.G1661A|CHD8_ENST00000555962.1_5'UTR|CHD8_ENST00000430710.3_Missense_Mutation_p.G1382A	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1661					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ATCTGGTCGGCCAGCCTTTTC	0.393000													5	22					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26112152	26112152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:26112152C>T	ENST00000381655.2	+	7	676	c.534C>T	c.(532-534)gtC>gtT	p.V178V	ATP8A2_ENST00000255283.8_Silent_p.V138V	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	138					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TTGTGAAGGTCGTCAATGGGC	0.448000													17	55					0	0	1	0	0
PLEKHA1	59338	broad.mit.edu	37	10	124189150	124189150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124189150C>T	ENST00000368988.1	+	13	1075	c.952C>T	c.(952-954)Ccg>Tcg	p.P318S	PLEKHA1_ENST00000368990.3_Missense_Mutation_p.P304L|PLEKHA1_ENST00000368989.2_Missense_Mutation_p.P318S|PLEKHA1_ENST00000538022.1_3'UTR|PLEKHA1_ENST00000433307.1_Missense_Mutation_p.P304L			Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0					B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	13		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GAGCATCCCCCCGGTCCTTCA	0.507000													11	37					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68704332	68704332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68704332C>T	ENST00000255078.3	+	13	2495	c.2384C>T	c.(2383-2385)cCc>cTc	p.P795L		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	795	Gln/Pro-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCCCTGGGACCCCCAGCAGGG	0.706000													12	24					0	0	1	0	0
HIST2H2BA	337875	broad.mit.edu	37	1	120906269	120906269	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120906269G>A	ENST00000430394.1	+	0	242					NR_027337.1																						CGCATCGCGGGAGAGGCGTCC	0.642000													36	105					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756624	15756624	+	Silent	SNP	C	C	T	rs116936513	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15756624C>T	ENST00000221307.7	+	3	342	c.294C>T	c.(292-294)atC>atT	p.I98I	CYP4F3_ENST00000591058.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000586182.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	98					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding	p.I98I(1)		endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GGCACGCAATCGTCCGCATCT	0.582000													21	43					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	892285	892285	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:892285C>T	ENST00000456758.2	+	14	1458	c.1458C>T	c.(1456-1458)atC>atT	p.I486I	SUN1_ENST00000401592.1_Silent_p.I297I|SUN1_ENST00000413514.2_Silent_p.I106I|SUN1_ENST00000425407.2_Silent_p.I214I|SUN1_ENST00000389574.3_Silent_p.I214I|SUN1_ENST00000405266.1_Silent_p.I334I|SUN1_ENST00000452783.2_Silent_p.I195I			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	324					cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TCTTGCTCATCCCACTCTTCC	0.418000													44	149					0	0	1	0	0
TRIM60	166655	broad.mit.edu	37	4	165962195	165962195	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:165962195G>A	ENST00000512596.1	+	3	1187	c.971G>A	c.(970-972)cGa>cAa	p.R324Q	TRIM60_ENST00000508504.1_Missense_Mutation_p.R324Q|TRIM60_ENST00000341062.5_Missense_Mutation_p.R324Q	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	324	B30.2/SPRY.					intracellular	zinc ion binding	p.R324Q(1)		NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		AGAAAAAAACGAAACATTTGT	0.418000													25	109					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110032729	110032729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110032729C>T	ENST00000369870.3	+	8	1230	c.1215C>T	c.(1213-1215)acC>acT	p.T405T		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	405										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		ATTATGCAACCCGGCCCCCAC	0.662000													22	65					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100950384	100950384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100950384C>T	ENST00000335290.6	+	4	1250	c.1024C>T	c.(1024-1026)Cat>Tat	p.H342Y	WDR25_ENST00000554998.1_Missense_Mutation_p.H342Y|WDR25_ENST00000542471.2_Missense_Mutation_p.H85Y|WDR25_ENST00000402312.3_Missense_Mutation_p.H342Y	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	342										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				CTTGAAATTCCATCCAAAAGA	0.398000													46	127					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171765837	171765837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:171765837G>A	ENST00000311601.5	-	13	2442	c.2272C>T	c.(2272-2274)Cca>Tca	p.P758S	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	758	Pro-rich.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTGCGGGGTGGGACCACAGGT	0.617000													14	50					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760080	115760080	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:115760080C>T	ENST00000427548.1	-	0	1733							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										TCAGTACATTCATATGGTTTC	0.403000													7	64					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46094037	46094037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46094037C>T	ENST00000323040.4	-	2	2032	c.1088G>A	c.(1087-1089)tGa>tAa	p.*363*	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	0						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		ACTCGGGGTTCATTGTGCTGG	0.577000													22	46					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123971140	123971140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123971140C>T	ENST00000369005.1	+	9	7540	c.7200C>T	c.(7198-7200)atC>atT	p.I2400I	TACC2_ENST00000334433.3_Silent_p.I2400I|TACC2_ENST00000358010.1_Silent_p.I546I|TACC2_ENST00000369004.3_Silent_p.I478I|TACC2_ENST00000513429.1_Silent_p.I546I|TACC2_ENST00000369001.1_Silent_p.I104I|TACC2_ENST00000369000.1_Silent_p.I104I|TACC2_ENST00000515603.1_Silent_p.I2355I|TACC2_ENST00000360561.3_Silent_p.I478I|TACC2_ENST00000368999.1_Silent_p.I478I|TACC2_ENST00000260733.3_Silent_p.I478I|TACC2_ENST00000515273.1_Silent_p.I2404I|TACC2_ENST00000453444.2_Silent_p.I2404I	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2400	SPAZ.					microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCTTTGAGATCCCAGCCAGTG	0.532000													30	104					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188243719	188243719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:188243719C>T	ENST00000409998.1	-	9	1229	c.448G>A	c.(448-450)Gga>Aga	p.G150R	CALCRL_ENST00000392370.3_Missense_Mutation_p.G150R|AC007319.1_ENST00000412276.1_RNA|CALCRL_ENST00000410068.1_Missense_Mutation_p.G150R|AC007319.1_ENST00000453517.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	150						integral to plasma membrane		p.G150*(1)		endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			ATAGACAATCCGTGTCCAATT	0.294000													18	167					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2430192	2430192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2430192C>T	ENST00000449969.1	+	18	2439	c.2278C>T	c.(2278-2280)Ccc>Tcc	p.P760S	PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000288766.5_Missense_Mutation_p.P75S|PLCH2_ENST00000419816.2_Missense_Mutation_p.P787S|PLCH2_ENST00000378486.3_Missense_Mutation_p.P787S|PLCH2_ENST00000378488.3_Missense_Mutation_p.P751S			O75038	PLCH2_HUMAN	phospholipase C, eta 2	787	C2.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GATCATCGACCCCTTTGTGGA	0.687000													6	15					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30961728	30961728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30961728C>T	ENST00000311813.4	+	2	487	c.432C>T	c.(430-432)atC>atT	p.I144I	AQP1_ENST00000509504.1_Silent_p.I321I|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Silent_p.I93I|AQP1_ENST00000409899.1_Silent_p.I29I|AQP1_ENST00000441328.2_Silent_p.I61I|AQP1_ENST00000434909.2_Silent_p.I204I	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				TCGAGATCATCGGGACCCTCC	0.657000													16	67					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57429363	57429363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57429363G>A	ENST00000371100.4	+	1	1595	c.1043G>A	c.(1042-1044)cGa>cAa	p.R348Q	GNAS_ENST00000371075.3_Intron|GNAS_ENST00000371098.2_Intron|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371099.2_Missense_Mutation_p.R348Q|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000371102.4_Missense_Mutation_p.R348Q|GNAS_ENST00000603534.1_Intron|GNAS_ENST00000306120.3_Missense_Mutation_p.E285K	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AAGAGAGAGCGAGCAGAGAGA	0.642000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			6	13					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56137167	56137167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56137167G>A	ENST00000319441.4	+	3	429	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K	PCK1_ENST00000535860.1_Intron|PCK1_ENST00000543666.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	89					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GGCCAGGATCGAAAGCAAGAC	0.557000													15	40					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929478	121929478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:121929478G>A	ENST00000265922.3	-	8	2631	c.2170C>T	c.(2170-2172)Ctg>Ttg	p.L724L	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		724					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CGGTGTTTCAGCATACAGGAG	0.552000													61	114					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451427	55451427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55451427C>T	ENST00000446217.1	-	6	1246	c.844G>A	c.(844-846)Ggc>Agc	p.G282S	NLRP7_ENST00000592784.1_Missense_Mutation_p.G254S|NLRP7_ENST00000340844.2_Missense_Mutation_p.G254S|NLRP7_ENST00000588756.1_Missense_Mutation_p.G254S|NLRP7_ENST00000448121.2_Missense_Mutation_p.G254S|NLRP7_ENST00000328092.5_Missense_Mutation_p.G254S|NLRP7_ENST00000590030.1_Missense_Mutation_p.G254S			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	254	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TCATCAAGGCCATCGACCACG	0.562000													43	106					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729527	18729527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18729527C>T	ENST00000440756.2	-	3	949	c.847G>A	c.(847-849)Gga>Aga	p.G283R	PSD3_ENST00000327040.8_Missense_Mutation_p.G283R|PSD3_ENST00000523619.1_Missense_Mutation_p.G218R			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	283					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CGATCACATCCCCCTGGGTGC	0.562000													7	108					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229772656	229772656	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:229772656C>T	ENST00000258243.2	+	4	2432	c.2296C>T	c.(2296-2298)Ctg>Ttg	p.L766L		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	766						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GGCCAGTGTCCTGCTGAGAAC	0.448000													29	66					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16908679	16908679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16908679C>T	ENST00000524140.2	+	16	3859	c.3441C>T	c.(3439-3441)tcC>tcT	p.S1147S	NWD1_ENST00000523826.1_Silent_p.S941S|NWD1_ENST00000379808.3_Silent_p.S1147S|NWD1_ENST00000339803.6_Silent_p.S1012S|NWD1_ENST00000552788.1_Silent_p.S1147S|NWD1_ENST00000549814.1_Silent_p.S1147S	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1147							ATP binding	p.S1012S(1)|p.S1147S(1)		NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCACGGGGTCCCTTGATGCGC	0.522000													67	231					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111317719	111317719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111317719C>T	ENST00000308208.5	+	6	741	c.499C>T	c.(499-501)Cac>Tac	p.H167Y	CCDC63_ENST00000550317.1_Intron|CCDC63_ENST00000552694.1_Missense_Mutation_p.H88Y|CCDC63_ENST00000545036.1_Missense_Mutation_p.H127Y	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	167										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GGTCACTGTTCACTTTGACAA	0.468000													44	128					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46407393	46407393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:46407393C>T	ENST00000433765.2	-	1	714	c.715G>A	c.(715-717)Gcc>Acc	p.A239T		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	239					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	AGCGTCTTGGCTTTCTTCTCC	0.642000													5	5					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325627	79325627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79325627G>A	ENST00000428286.1	-	8	1686	c.486C>T	c.(484-486)ttC>ttT	p.F162F	PRUNE2_ENST00000376718.3_Silent_p.F521F			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	521					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity	p.F521L(1)		endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TGTTGGGGAAGAAGTCATCTG	0.512000													9	21					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	8000004	8000004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8000004G>A	ENST00000377507.3	-	2	217	c.51C>T	c.(49-51)aaC>aaT	p.N17N		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	17					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		TCCTCTCAAAGTTGAGGACCA	0.443000													18	41					0	0	1	0	0
FAM187B	148109	broad.mit.edu	37	19	35715768	35715768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35715768G>A	ENST00000324675.3	-	2	1118	c.1070C>T	c.(1069-1071)tCc>tTc	p.S357F		NM_152481.1	NP_689694.1	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	357						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	9						CCTGCCCGGGGAAGGGTGGAT	0.677000													19	26					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145562712	145562712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145562712G>A	ENST00000355594.4	+	10	2487	c.2400G>A	c.(2398-2400)atG>atA	p.M800I		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	800										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AGGCCACGATGAGCGGGAAGA	0.637000													9	25					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113802129	113802129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113802129G>A	ENST00000260191.2	+	3	494	c.237G>A	c.(235-237)aaG>aaA	p.K79K	HTR3B_ENST00000537778.1_Silent_p.K68K	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	79					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		AAATATTAAAGACAAGTGTAT	0.318000													15	37					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39495059	39495059	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39495059T>C	ENST00000265707.5	+	9	709	c.664T>C	c.(664-666)Ttt>Ctt	p.F222L	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.F198L	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	222	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TTTTTAGATGTTTACCCAGTT	0.294000													9	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083644	9083644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9083644G>A	ENST00000397910.4	-	1	8374	c.8171C>T	c.(8170-8172)cCt>cTt	p.P2724L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2724	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTGGAAGAAGGATGGAGTGG	0.468000													28	90					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69046420	69046420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69046420G>A	ENST00000295381.3	+	9	1585	c.1166G>A	c.(1165-1167)cGa>cAa	p.R389Q	ARHGAP25_ENST00000409202.3_Missense_Mutation_p.R390Q|ARHGAP25_ENST00000497079.1_Missense_Mutation_p.R383Q|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.R383Q|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.R350Q|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.R83Q|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.R382Q	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	389					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						GAAGACCTCCGAATTTCTAGG	0.532000													38	81					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111966270	111966270	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111966270G>A	ENST00000369732.3	-	5	433	c.378C>T	c.(376-378)tcC>tcT	p.S126S	OVGP1_ENST00000540696.1_Silent_p.S66S	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	126					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TCCTCAGAAGGGATATAACTG	0.443000													45	70					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21208825	21208825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21208825C>T	ENST00000574002.1	-	20	2696	c.2214G>A	c.(2212-2214)gaG>gaA	p.E738E	ZP2_ENST00000219593.4_Silent_p.E738E|AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Silent_p.E729E			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	738					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		CAGTCCTTTTCTCGTACAGGT	0.453000													11	77					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71329576	71329576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71329576G>A	ENST00000260382.5	+	15	2022	c.1762G>A	c.(1762-1764)Gaa>Aaa	p.E588K	LRRC49_ENST00000560369.1_Missense_Mutation_p.E593K|LRRC49_ENST00000544974.2_Missense_Mutation_p.E578K|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000443425.2_Missense_Mutation_p.E544K|LRRC49_ENST00000560691.1_Missense_Mutation_p.E294K|LRRC49_ENST00000560158.2_Missense_Mutation_p.E276K	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	588						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						TATTATCAACGAAGAAAATAA	0.313000													50	171					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	48996764	48996764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48996764G>A	ENST00000226432.4	+	5	823	c.640G>A	c.(640-642)Gga>Aga	p.G214R	CWH43_ENST00000513409.1_Missense_Mutation_p.G187R	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	214					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						CTGGGTTTTTGGAGAAGTCTC	0.547000													46	116					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77918525	77918525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77918525G>A	ENST00000302536.2	+	7	1056	c.903G>A	c.(901-903)gtG>gtA	p.V301V		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	301							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						TGGAGAAGGTGAACCCCATCA	0.512000													10	15					0	0	1	0	0
UBE2U	148581	broad.mit.edu	37	1	64707407	64707407	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:64707407G>A	ENST00000371077.4	+	8	1092	c.668G>A	c.(667-669)tGg>tAg	p.W223*	UBE2U_ENST00000464349.1_3'UTR|UBE2U_ENST00000371076.3_Nonsense_Mutation_p.W223*			Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)	223							ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(3)|lung(2)|skin(1)	6						CAGAAAGAATGGAATTTAAAG	0.299000													11	43					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75831063	75831063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:75831063G>A	ENST00000322507.8	-	44	7350	c.7041C>T	c.(7039-7041)ttC>ttT	p.F2347F	COL12A1_ENST00000345356.6_Silent_p.F1183F|COL12A1_ENST00000483888.2_Silent_p.F2347F|COL12A1_ENST00000416123.2_Silent_p.F2347F	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2347	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCACAGTATTGAAGATGAATT	0.438000													12	78					0	0	1	0	0
SLC39A10	57181	broad.mit.edu	37	2	196581607	196581607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196581607C>T	ENST00000409086.3	+	7	2218	c.1943C>T	c.(1942-1944)tCt>tTt	p.S648F	SLC39A10_ENST00000359634.5_Missense_Mutation_p.S648F|SLC39A10_ENST00000541054.1_Missense_Mutation_p.S198F	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	648	His-rich.				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			CACAAGCATTCTCATCATTCC	0.488000													21	108					0	0	1	0	0
TLE2	7089	broad.mit.edu	37	19	3006496	3006496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3006496C>T	ENST00000262953.6	-	15	1684	c.1422G>A	c.(1420-1422)acG>acA	p.T474T	TLE2_ENST00000426948.2_Silent_p.T488T|TLE2_ENST00000443826.3_Silent_p.T352T|TLE2_ENST00000586422.1_Intron|TLE2_ENST00000447365.2_Silent_p.T141T|TLE2_ENST00000591529.1_Silent_p.T488T|TLE2_ENST00000590536.1_Silent_p.T475T|TLE2_ENST00000455444.2_Silent_p.T352T	NM_003260.4	NP_003251.2	Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	474					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTGCCGCCCGTGTACACAT	0.716000													5	17					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348695	140348695	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348695C>T	ENST00000289269.5	+	1	2876	c.2344C>T	c.(2344-2346)Cga>Tga	p.R782*	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		782					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTGAAGTTCGAGGGAATGG	0.507000													21	58					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7697666	7697666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7697666C>T	ENST00000572933.1	+	49	9124	c.7664C>T	c.(7663-7665)aCc>aTc	p.T2555I	DNAH2_ENST00000389173.2_Missense_Mutation_p.T2555I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2555	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ATCAACATGACCTTCCCCACA	0.602000													21	27					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106321778	106321778	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106321778C>T	ENST00000390559.2	-	0	455																											CCACCTGCTTCCCCTCGCGCA	0.642000													13	41					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25671518	25671518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25671518C>T	ENST00000281589.3	+	1	1219	c.1182C>T	c.(1180-1182)aaC>aaT	p.N394N		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	394					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CTGTGCCCAACCAGCGAGCAC	0.498000													35	95					0	0	1	0	0
PRKCE	5581	broad.mit.edu	37	2	46237648	46237648	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:46237648C>T	ENST00000306156.3	+	10	1756	c.1429C>T	c.(1429-1431)Cag>Tag	p.Q477*	PRKCE_ENST00000394874.1_Nonsense_Mutation_p.Q200*	NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	477	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity		MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CTGCTGCTTCCAGACCAAGGT	0.473000													9	68					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158505106	158505106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:158505106C>T	ENST00000355585.4	+	22	3183	c.3108C>T	c.(3106-3108)ctC>ctT	p.L1036L	SYNJ2_ENST00000367122.2_Silent_p.L1036L|SYNJ2_ENST00000367112.1_Silent_p.L121L|SYNJ2_ENST00000367121.3_Silent_p.L1036L	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	1036							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		ACAGTGAACTCGGGGGAGACG	0.517000													106	157					0	0	1	0	0
CCL25	6370	broad.mit.edu	37	19	8121312	8121312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8121312G>A	ENST00000253451.4	+	4	360	c.254G>A	c.(253-255)aGa>aAa	p.R85K	CCL25_ENST00000390669.3_Missense_Mutation_p.R85K|CCL25_ENST00000315626.4_Intron	NM_001201359.1|NM_005624.3	NP_001188288.1|NP_005615.2	O15444	CCL25_HUMAN	chemokine (C-C motif) ligand 25	85					chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|hormone activity			NS(1)|endometrium(1)|lung(1)|skin(1)|urinary_tract(1)	5						GAGGTGCAGAGAGCCATGAAG	0.557000													11	32					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36766013	36766013	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36766013G>A	ENST00000244751.2	-	6	957	c.333C>T	c.(331-333)ttC>ttT	p.F111F		NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	111	C2 1.									central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CCTGGCCCAGGAAATCCTGCA	0.602000													8	20					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155528041	155528041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155528041G>A	ENST00000404648.3	-	8	1184	c.945C>T	c.(943-945)gcC>gcT	p.A315A	FGG_ENST00000336098.3_Silent_p.A315A|FGG_ENST00000407946.1_Silent_p.A323A|FGG_ENST00000405164.1_Silent_p.A323A	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	315	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AGCCATCAAAGGCATCTCCAG	0.463000													56	95					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47678608	47678608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47678608G>A	ENST00000283303.2	+	4	544	c.286G>A	c.(286-288)Gaa>Aaa	p.E96K	GPR115_ENST00000327753.3_Missense_Mutation_p.E96K|GPR115_ENST00000371220.1_Missense_Mutation_p.E153K	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	96					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CCTTTCTGTGGAAAAACTCTT	0.393000													32	65					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17614116	17614116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:17614116G>A	ENST00000377813.1	-	8	2902	c.2599C>T	c.(2599-2601)Ctg>Ttg	p.L867L	RRBP1_ENST00000360807.4_Silent_p.L434L|RRBP1_ENST00000246043.4_Silent_p.L867L|RRBP1_ENST00000455029.2_Silent_p.L208L|RRBP1_ENST00000377807.2_Silent_p.L434L			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	867					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						TGCAGCTGCAGGACCTGCTTC	0.642000													8	70					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76468259	76468259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:76468259G>A	ENST00000396423.2	+	6	782	c.658G>A	c.(658-660)Gga>Aga	p.G220R	HNF4G_ENST00000354370.1_Missense_Mutation_p.G183R	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	183					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			CTTACTGCTTGGAGCTACAAA	0.289000													15	65					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47746591	47746591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47746591G>A	ENST00000273857.4	-	5	626	c.627C>T	c.(625-627)ctC>ctT	p.L209L	CORIN_ENST00000502252.1_Silent_p.L142L|CORIN_ENST00000505909.1_Silent_p.L209L|CORIN_ENST00000504584.1_Silent_p.L209L|CORIN_ENST00000508498.1_Silent_p.L70L	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	209	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TACAGGGCAGGAGTCCATGAC	0.418000													13	139					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20620576	20620576	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20620576T>C	ENST00000504154.1	+	37	4786	c.4534T>C	c.(4534-4536)Ttt>Ctt	p.F1512L	SLIT2_ENST00000273739.5_Missense_Mutation_p.F1525L|SLIT2_ENST00000503823.1_Missense_Mutation_p.F1504L|SLIT2_ENST00000503837.1_Missense_Mutation_p.F1508L	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1512	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CGGCTCCTCCTTTGTGGACGA	0.547000													22	32					0	0	1	0	0
OR2K2	26248	broad.mit.edu	37	9	114090282	114090282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114090282C>T	ENST00000374428.1	-	1	518	c.519G>A	c.(517-519)atG>atA	p.M173I	OR2K2_ENST00000302681.1_Missense_Mutation_p.M144I			Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)	20						AGACCGTAGCCATCCGTGCAC	0.547000													29	70					0	0	1	0	0
OR10A7	121364	broad.mit.edu	37	12	55615680	55615680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55615680G>A	ENST00000326258.1	+	1	872	c.872G>A	c.(871-873)gGc>gAc	p.G291D		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G291V(1)		endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						ATCATCTACGGCCTGAGGAAC	0.448000													24	58					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139657446	139657446	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139657446C>T	ENST00000263552.6	+	12	1243	c.705C>T	c.(703-705)tcC>tcT	p.S235S	TBXAS1_ENST00000425687.1_Silent_p.S167S|TBXAS1_ENST00000416849.2_Silent_p.S281S|TBXAS1_ENST00000411653.1_Silent_p.S234S|TBXAS1_ENST00000414508.2_Silent_p.S235S|TBXAS1_ENST00000458722.1_Silent_p.S280S|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000336425.5_Silent_p.S234S|TBXAS1_ENST00000436047.2_Silent_p.S235S|TBXAS1_ENST00000448866.1_Silent_p.S234S	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	234					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CATTTCCATCCATAATGGTCC	0.458000													24	67					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30532907	30532907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30532907C>T	ENST00000356798.6	+	31	3614	c.3434C>T	c.(3433-3435)tCt>tTt	p.S1145F	ITGAL_ENST00000358164.5_Missense_Mutation_p.S1061F|ITGAL_ENST00000433423.2_Missense_Mutation_p.S379F	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1145					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CAGCTGGCATCTGGGCAAGAG	0.582000													35	79					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9370586	9370586	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9370586T>C	ENST00000378501.2	+	13	1234	c.1219T>C	c.(1219-1221)Tcc>Ccc	p.S407P	PLCB4_ENST00000414679.2_Missense_Mutation_p.S407P|PLCB4_ENST00000378493.1_Missense_Mutation_p.S407P|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.S407P|PLCB4_ENST00000378473.3_Missense_Mutation_p.S407P|PLCB4_ENST00000334005.3_Missense_Mutation_p.S407P	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	407	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TGTAATTCTCTCCTTTGAAAA	0.368000													27	93					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71555572	71555572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71555572C>T	ENST00000265382.3	+	14	1673	c.1368C>T	c.(1366-1368)tcC>tcT	p.S456S	PIP5K1B_ENST00000541509.1_Silent_p.S456S	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	456						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		CCCTGGGATCCCGACACAGGC	0.433000													32	147					0	0	1	0	0
WDR18	57418	broad.mit.edu	37	19	990989	990989	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:990989C>T	ENST00000251289.5	+	5	758	c.735C>T	c.(733-735)ttC>ttT	p.F245F	WDR18_ENST00000587001.2_Silent_p.F245F	NM_024100.3	NP_077005.2	Q9BV38	WDR18_HUMAN	WD repeat domain 18	245										endometrium(1)|kidney(2)|lung(2)|skin(2)	7		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGACCTCTTCACCTGGGTGA	0.652000													15	34					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35781030	35781030	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:35781030C>T	ENST00000187397.4	+	17	2322	c.1866C>T	c.(1864-1866)ccC>ccT	p.P622P	ARPP21_ENST00000337271.5_Silent_p.P603P|ARPP21_ENST00000444190.1_Silent_p.P603P|ARPP21_ENST00000417925.1_Silent_p.P623P|ARPP21_ENST00000458225.1_Silent_p.P623P	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	622	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						AGCCCCCTCCCTCACCACAGG	0.562000													23	49					0	0	1	0	0
SLC8B1	80024	broad.mit.edu	37	12	113754419	113754419	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113754419G>A	ENST00000552014.1	-	11	1420	c.905C>T	c.(904-906)gCt>gTt	p.A302V	SLC24A6_ENST00000546737.1_Missense_Mutation_p.A246V|SLC24A6_ENST00000202831.3_Missense_Mutation_p.A302V|SLC24A6_ENST00000553238.1_5'UTR			Q6J4K2	NCKX6_HUMAN		302					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						CAGGATCTGAGCCGTGGTCTC	0.577000													32	273					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81111096	81111096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81111096G>A	ENST00000228644.3	+	1	406	c.254G>A	c.(253-255)cGg>cAg	p.R85Q		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	85					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						ATGGATCGGCGGAAGGCAGCC	0.627000													15	32					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100491719	100491719	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100491719C>T	ENST00000302913.4	-	2	273	c.135G>A	c.(133-135)ggG>ggA	p.G45G	ACHE_ENST00000411582.1_Silent_p.G45G|ACHE_ENST00000241069.5_Silent_p.G45G|ACHE_ENST00000428317.1_Silent_p.G45G|ACHE_ENST00000412389.1_Silent_p.G45G|ACHE_ENST00000419336.2_Silent_p.G45G	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	45					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GCAGCCGGCCCCCACGCACCG	0.697000													3	15					0	0	1	0	0
FRS2	10818	broad.mit.edu	37	12	69965947	69965947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:69965947C>T	ENST00000299293.2	+	9	972	c.462C>T	c.(460-462)ccC>ccT	p.P154P	FRS2_ENST00000549921.1_Silent_p.P154P|FRS2_ENST00000550389.1_Silent_p.P154P|FRS2_ENST00000397997.2_Silent_p.P154P	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	154					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			CCCGATATCCCTCATTTGGAG	0.483000													25	79					0	0	1	0	0
IGHV4-59	28392	broad.mit.edu	37	14	107083553	107083553	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107083553G>A	ENST00000455737.1	-	0	90																											CCTGGGACAGGACCCCTGTGA	0.602000													15	46					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44083474	44083474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44083474C>T	ENST00000359947.4	+	25	4603	c.4263C>T	c.(4261-4263)atC>atT	p.I1421I	PTPRF_ENST00000422171.2_Silent_p.I780I|PTPRF_ENST00000438120.1_Silent_p.I1412I|PTPRF_ENST00000372414.3_Silent_p.I1421I|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Silent_p.I1412I	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1421	Tyrosine-protein phosphatase 1.			I -> T (in Ref. 5; AAH48768).	transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATGCCTACATCGCCACGCAGG	0.582000													15	51					0	0	1	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806871	97806871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97806871C>T	ENST00000358642.2	+	1	855	c.855C>T	c.(853-855)ccC>ccT	p.P285P		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						TTATAATTCCCCTGCTAAACC	0.373000													16	48					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74868895	74868895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74868895C>T	ENST00000428789.2	+	1	167	c.64C>T	c.(64-66)Ctt>Ttt	p.L22F	MGAT5B_ENST00000569840.2_Intron|MGAT5B_ENST00000301618.4_Intron|MGAT5B_ENST00000374998.3_Intron|MGAT5B_ENST00000565675.1_Intron	NM_198955.1	NP_945193.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	12						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CACGATGGCCCTTCCTGCCCT	0.577000													9	38					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139719887	139719887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139719887C>T	ENST00000263552.6	+	17	2131	c.1593C>T	c.(1591-1593)atC>atT	p.I531I	TBXAS1_ENST00000425687.1_Silent_p.I463I|TBXAS1_ENST00000416849.2_Silent_p.I577I|TBXAS1_ENST00000411653.1_3'UTR|TBXAS1_ENST00000414508.2_3'UTR|TBXAS1_ENST00000458722.1_Silent_p.I576I|TBXAS1_ENST00000336425.5_Silent_p.I530I|TBXAS1_ENST00000436047.2_Silent_p.I531I|TBXAS1_ENST00000448866.1_Silent_p.I530I	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	530					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					ATATCAAGATCGTATCCCGCT	0.428000													19	47					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13764672	13764672	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13764672G>A	ENST00000279593.3	-	8	1976	c.1767C>T	c.(1765-1767)ctC>ctT	p.L589L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	589					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGCCATCAGCGAGGCACCTGT	0.483000													19	92					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184075040	184075040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184075040G>A	ENST00000265593.4	-	9	1084	c.913C>T	c.(913-915)Ctc>Ttc	p.L305F	CLCN2_ENST00000457512.1_Missense_Mutation_p.L305F|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000434054.2_Missense_Mutation_p.L261F|CLCN2_ENST00000423355.2_5'UTR|CLCN2_ENST00000344937.7_Missense_Mutation_p.L305F	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	305						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	GTTTTGAAGAGGGCTGTAATA	0.612000													27	59					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508190	37508190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37508190G>A	ENST00000374660.1	+	40	3838	c.3739G>A	c.(3739-3741)Gaa>Aaa	p.E1247K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E1128K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E1128K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1184						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TAAATTGAAGGAAAAACAAGA	0.368000													10	146					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76395319	76395319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76395319C>T	ENST00000357063.3	+	15	3630	c.2370C>T	c.(2368-2370)tcC>tcT	p.S790S	LMO7_ENST00000341547.4_Silent_p.S456S|LMO7_ENST00000377534.3_Silent_p.S790S|LMO7_ENST00000321797.8_Silent_p.S505S|LMO7_ENST00000465261.2_Silent_p.S505S|LMO7_ENST00000526202.1_Silent_p.S355S			Q8WWI1	LMO7_HUMAN	LIM domain 7	790						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TAAGGGAATCCCAAAATCAAA	0.453000													12	31					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618198	77618198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77618198G>A	ENST00000521891.2	+	2	2323	c.1875G>A	c.(1873-1875)tcG>tcA	p.S625S	ZFHX4_ENST00000050961.6_Silent_p.S625S|ZFHX4_ENST00000455469.2_Silent_p.S625S|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Silent_p.S625S	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	625						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGGGGTCTTCGAGGTCTCTTG	0.532000										HNSCC(33;0.089)			19	48					0	0	1	0	0
ABHD6	57406	broad.mit.edu	37	3	58271159	58271159	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58271159C>T	ENST00000478253.1	+	9	1317	c.816C>T	c.(814-816)atC>atT	p.I272I	ABHD6_ENST00000295962.4_Silent_p.I272I			Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	272						integral to membrane	acylglycerol lipase activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	16				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)		CGACGCAGATCATCTGGGGGA	0.483000													21	64					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233704569	233704569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233704569C>T	ENST00000373566.3	+	24	3040	c.2843C>T	c.(2842-2844)tCt>tTt	p.S948F	GIGYF2_ENST00000409451.3_Missense_Mutation_p.S947F|GIGYF2_ENST00000452341.2_Missense_Mutation_p.S757F|GIGYF2_ENST00000409547.1_Missense_Mutation_p.S926F|GIGYF2_ENST00000409480.1_Missense_Mutation_p.S948F|GIGYF2_ENST00000373563.4_Missense_Mutation_p.S926F|GIGYF2_ENST00000409196.3_Missense_Mutation_p.S920F			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	926	Gln-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CTTCCTTCTTCTTCAACGTGG	0.453000													12	55					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17053020	17053020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:17053020C>T	ENST00000418129.2	+	2	2269	c.1804C>T	c.(1804-1806)Ctc>Ttc	p.L602F	PLCL2_ENST00000396755.2_Missense_Mutation_p.L602F|PLCL2_ENST00000432376.1_Missense_Mutation_p.L602F	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	728					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TGGCTATGTCCTCCGGCCAGC	0.483000													23	66					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124377772	124377772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124377772G>A	ENST00000368909.3	+	38	4850	c.4744G>A	c.(4744-4746)Gag>Aag	p.E1582K	DMBT1_ENST00000330163.4_Missense_Mutation_p.E954K|DMBT1_ENST00000368955.3_Missense_Mutation_p.E1572K|DMBT1_ENST00000359586.6_Missense_Mutation_p.E433K|DMBT1_ENST00000368956.2_Missense_Mutation_p.E954K|DMBT1_ENST00000344338.3_Missense_Mutation_p.E1572K|DMBT1_ENST00000338354.3_Missense_Mutation_p.E1582K	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1582	SRCR 12.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTCAGGACACGAGTCTTACCT	0.597000													59	159					0	0	1	0	0
STXBP5	134957	broad.mit.edu	37	6	147685156	147685156	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:147685156C>T	ENST00000367481.3	+	23	2935	c.2827C>T	c.(2827-2829)Ctg>Ttg	p.L943L	STXBP5_ENST00000179882.6_Silent_p.L634L|STXBP5_ENST00000321680.6_Silent_p.L979L|STXBP5_ENST00000367480.3_Silent_p.L926L	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	979					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TTTAAGACCTCTGTTGGATGT	0.358000													74	107					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191385	152191385	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152191385C>T	ENST00000368801.2	-	3	2795	c.2720G>A	c.(2719-2721)gGc>gAc	p.G907D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	907					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCATGTCGGCCATAGCTGGG	0.652000													72	191					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43384806	43384806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43384806C>T	ENST00000372851.3	-	6	845	c.779G>A	c.(778-780)aGc>aAc	p.S260N	RIMS4_ENST00000541604.2_Missense_Mutation_p.S261N	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	260					exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				CCCCACGGTGCTCTCGAGGGA	0.677000													52	105					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96025687	96025687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96025687G>A	ENST00000260766.3	+	16	4887	c.4253G>A	c.(4252-4254)gGa>gAa	p.G1418E	PLCE1_ENST00000371375.1_Missense_Mutation_p.G1110E|PLCE1_ENST00000371380.2_Missense_Mutation_p.G1418E|PLCE1_ENST00000371385.3_Missense_Mutation_p.G1110E	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1418	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				CAGCTCAAAGGAGAATCCTCG	0.423000													34	71					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70871758	70871758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70871758G>A	ENST00000393567.2	-	77	13227	c.13077C>T	c.(13075-13077)ctC>ctT	p.L4359L		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	4359										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGTTCACCTCGAGGTGAGTGG	0.453000													24	46					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64873464	64873464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64873464G>A	ENST00000533854.1	+	2	251	c.14G>A	c.(13-15)gGg>gAg	p.G5E	CACNG5_ENST00000169565.3_Missense_Mutation_p.G5E|CACNG5_ENST00000307139.3_Missense_Mutation_p.G5E			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	5					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			AGTGCCTGCGGGAGGAAGGCC	0.632000													17	67					0	0	1	0	0
CLCN4	1183	broad.mit.edu	37	X	10176100	10176100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:10176100C>T	ENST00000380833.4	+	9	1250	c.859C>T	c.(859-861)Ccc>Tcc	p.P287S	CLCN4_ENST00000380829.1_Missense_Mutation_p.P287S|CLCN4_ENST00000421085.2_Missense_Mutation_p.P193S	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	287						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TTACTACTTTCCCCTGAAGAC	0.498000													66	99					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25886970	25886970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25886970G>A	ENST00000376351.3	+	11	2774	c.2415G>A	c.(2413-2415)gaG>gaA	p.E805E	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	805						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCAAGGAGGAGACCCTGAAAA	0.547000													44	121					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37036109	37036109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37036109C>T	ENST00000379242.3	+	15	2186	c.1884C>T	c.(1882-1884)gcC>gcT	p.A628A	VIT_ENST00000379241.3_Silent_p.A591A|VIT_ENST00000404084.1_Silent_p.A565A|VIT_ENST00000389975.3_Silent_p.A613A|VIT_ENST00000497382.1_Silent_p.A282A|VIT_ENST00000401530.1_Silent_p.A592A	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	613	VWFA 2.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				GGATCCCAGCCATGGCTGCCC	0.582000													14	37					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156642416	156642416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156642416C>T	ENST00000368223.3	-	4	1696	c.1564G>A	c.(1564-1566)Gaa>Aaa	p.E522K		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	522	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCCCATATTTCCTGCTGCAAG	0.483000													26	203					0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24839717	24839717	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24839717G>A	ENST00000413692.2	+	3	1446	c.1302G>A	c.(1300-1302)gaG>gaA	p.E434E	NFATC4_ENST00000440487.2_3'UTR|NFATC4_ENST00000553879.1_Silent_p.E301E|NFATC4_ENST00000555590.1_Silent_p.E384E|NFATC4_ENST00000554966.1_Silent_p.E384E|NFATC4_ENST00000555453.1_Silent_p.E359E|NFATC4_ENST00000553469.1_Silent_p.E403E|NFATC4_ENST00000557451.1_Silent_p.E301E|NFATC4_ENST00000553708.1_Silent_p.E371E|NFATC4_ENST00000556169.1_Silent_p.E359E|NFATC4_ENST00000424781.2_Silent_p.E384E|NFATC4_ENST00000554591.1_Silent_p.E434E|NFATC4_ENST00000556279.1_Silent_p.E403E|NFATC4_ENST00000422617.3_Silent_p.E359E|NFATC4_ENST00000554050.1_Silent_p.E371E|NFATC4_ENST00000554344.1_Silent_p.E301E|NFATC4_ENST00000539237.2_Silent_p.E403E|NFATC4_ENST00000554661.1_Silent_p.E301E|NFATC4_ENST00000250373.4_Silent_p.E371E	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	371	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CCCGGAAGGAGGTGGCTGGCA	0.642000													9	46					0	0	1	0	0
SLC44A3	126969	broad.mit.edu	37	1	95307561	95307561	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:95307561T>G	ENST00000271227.6	+	8	868	c.766T>G	c.(766-768)Tgc>Ggc	p.C256G	SLC44A3_ENST00000527077.1_Missense_Mutation_p.C188G|SLC44A3_ENST00000529450.1_Missense_Mutation_p.C224G|SLC44A3_ENST00000532427.1_Missense_Mutation_p.C176G|SLC44A3_ENST00000530397.1_3'UTR|RP11-465K1.2_ENST00000422162.1_RNA|SLC44A3_ENST00000467909.1_Missense_Mutation_p.C208G|SLC44A3_ENST00000446120.2_Missense_Mutation_p.C220G	NM_001114106.2|NM_001258340.1|NM_001258341.1	NP_001107578.1|NP_001245269.1|NP_001245270.1	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3	256						integral to membrane|plasma membrane	choline transmembrane transporter activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|prostate(2)|stomach(1)|urinary_tract(1)	23		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	TCTAGTTGTCTGCGGTGTTTT	0.483000													70	235					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58306080	58306080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:58306080C>T	ENST00000249750.4	-	3	1106	c.339G>A	c.(337-339)gtG>gtA	p.V113V	ALDH1A2_ENST00000347587.3_Silent_p.V113V|ALDH1A2_ENST00000559517.1_Silent_p.V17V|ALDH1A2_ENST00000558231.1_Silent_p.V84V|ALDH1A2_ENST00000537372.1_Silent_p.V92V	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	113					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TGTCCCGTTCCACCAAGTCTG	0.473000													128	343					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92577409	92577409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92577409C>T	ENST00000298047.6	+	18	10893	c.10876C>T	c.(10876-10878)Cgc>Tgc	p.R3626C	FAT3_ENST00000409404.2_Missense_Mutation_p.R3626C|FAT3_ENST00000525166.1_Missense_Mutation_p.R3476C			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3626	Cadherin 33.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAGTGATGGTCGCTTCCAGGT	0.502000										TCGA Ovarian(4;0.039)			81	155					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50740495	50740495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:50740495G>A	ENST00000008391.3	+	8	1505	c.1277G>A	c.(1276-1278)gGa>gAa	p.G426E		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	426							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TCTGGCCAAGGACATGCCAAC	0.488000													18	44					0	0	1	0	0
BTN2A1	11120	broad.mit.edu	37	6	26463639	26463639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26463639C>T	ENST00000429381.1	+	4	810	c.598C>T	c.(598-600)Ctc>Ttc	p.L200F	BTN2A1_ENST00000469185.1_Missense_Mutation_p.L200F|BTN2A1_ENST00000312541.5_Missense_Mutation_p.L200F|BTN2A1_ENST00000541522.1_Missense_Mutation_p.L139F			Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1	200					lipid metabolic process	integral to plasma membrane				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(3)	27						TGCAGACGGCCTCTTCATGGT	0.557000													38	114					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55003839	55003839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:55003839G>A	ENST00000474759.1	+	29	2572	c.2524G>A	c.(2524-2526)Gat>Aat	p.D842N	CACNA2D3_ENST00000415676.2_Missense_Mutation_p.D842N|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.D842N|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.D748N	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	842						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGCTTCCCTGGATGGCAAATG	0.512000													24	29					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22922660	22922660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22922660G>A	ENST00000166244.3	+	9	1831	c.1759G>A	c.(1759-1761)Gga>Aga	p.G587R		NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	587						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CTATCAGAATGGACAGGGTGA	0.652000													10	39					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167086743	167086743	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167086743G>A	ENST00000361200.2	+	4	550	c.384G>A	c.(382-384)gaG>gaA	p.E128E	DUSP27_ENST00000271385.5_Silent_p.E128E|DUSP27_ENST00000443333.1_Silent_p.E128E			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	128					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						ATCGCCAAGAGGCGCCCTGGA	0.547000													5	15					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111164437	111164437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111164437C>T	ENST00000360467.5	+	48	5344	c.5038C>T	c.(5038-5040)Ccc>Tcc	p.P1680S		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1680	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GACCACCATTCCCGAGCAGAG	0.612000													17	87					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237796914	237796914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237796914C>T	ENST00000366574.2	+	43	6909	c.6592C>T	c.(6592-6594)Cgt>Tgt	p.R2198C	RYR2_ENST00000360064.6_Missense_Mutation_p.R2196C|RYR2_ENST00000542537.1_Missense_Mutation_p.R2182C	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2198	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.R2196S(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAACTGTTGCCGTTTTCTCTG	0.388000													45	139					0	0	1	0	0
TINAGL1	64129	broad.mit.edu	37	1	32042974	32042974	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32042974C>T	ENST00000271064.7	+	2	301	c.225C>T	c.(223-225)ctC>ctT	p.L75L	TINAGL1_ENST00000481165.1_3'UTR|TINAGL1_ENST00000537531.1_Silent_p.L75L|TINAGL1_ENST00000441210.2_Silent_p.L75L|TINAGL1_ENST00000457433.2_Silent_p.L75L	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	75	SMB.				endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		ACTGTGACCTCTTCTGCAACC	0.657000													33	148					0	0	1	0	0
POMGNT1	55624	broad.mit.edu	37	1	46655138	46655138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46655138G>A	ENST00000371984.3	-	21	2044	c.1887C>T	c.(1885-1887)tcC>tcT	p.S629S	POMGNT1_ENST00000371992.1_Intron|POMGNT1_ENST00000535522.1_Silent_p.S607S|POMGNT1_ENST00000396420.3_3'UTR|POMGNT1_ENST00000371986.3_Intron	NM_017739.3	NP_060209.3	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	629					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					ACGAGTAGGGGGAAGCCGGGA	0.527000													10	19					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215640	140215640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140215640G>A	ENST00000525929.1	+	1	1672	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.E558K|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCTGGACGAGAACGACAA	0.692000													56	129					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141752740	141752740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141752740C>T	ENST00000475668.2	+	26	3169	c.3115C>T	c.(3115-3117)Cgc>Tgc	p.R1039C	MGAM_ENST00000549489.2_Missense_Mutation_p.R1039C			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1039					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GAACCCCCTTCGCCTGGATGT	0.458000													11	57					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42695454	42695454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42695454G>A	ENST00000358131.5	+	7	1595	c.1387G>A	c.(1387-1389)Gac>Aac	p.D463N	TOX2_ENST00000372999.1_Missense_Mutation_p.D439N|TOX2_ENST00000435864.2_Missense_Mutation_p.D359N|TOX2_ENST00000423191.1_Missense_Mutation_p.D439N|TOX2_ENST00000341197.3_Missense_Mutation_p.D481N	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CGGGGACTGGGACAGCAGCTA	0.637000													43	121					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28618127	28618127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28618127G>A	ENST00000395609.1	-	8	1307	c.549C>T	c.(547-549)agC>agT	p.S183S	SULT1A1_ENST00000569554.1_Silent_p.S183S|SULT1A1_ENST00000314752.7_Silent_p.S183S|SULT1A1_ENST00000350842.4_Silent_p.S105S|SULT1A1_ENST00000395607.1_Silent_p.S183S			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	183					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						GGTGGGTGCGGCTCAGCTCCC	0.597000													14	155					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139876656	139876656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139876656C>T	ENST00000297183.6	+	15	2921	c.2797C>T	c.(2797-2799)Cca>Tca	p.P933S	ANKHD1_ENST00000462121.1_3'UTR|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P933S|ANKHD1_ENST00000360839.2_Missense_Mutation_p.P933S	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTATCATCTCCACAGTGTAA	0.398000													60	170					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174689	207174689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207174689G>A	ENST00000374423.3	+	5	5823	c.5437G>A	c.(5437-5439)Gat>Aat	p.D1813N		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1813							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GGATAATCCTGATGAACCAGT	0.393000													28	55					0	0	1	0	0
SIX4	51804	broad.mit.edu	37	14	61187102	61187102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:61187102G>A	ENST00000216513.4	-	2	984	c.925C>T	c.(925-927)Cct>Tct	p.P309S		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	309						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		AGTGGGTGAGGAGATAAATCC	0.458000													42	92					0	0	1	0	0
NBL1	4681	broad.mit.edu	37	1	19981573	19981573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19981573C>T	ENST00000375136.3	+	2	353	c.50C>T	c.(49-51)gCt>gTt	p.A17V	MINOS1-NBL1_ENST00000602662.1_Missense_Mutation_p.A17V|NBL1_ENST00000289749.2_Missense_Mutation_p.A52V|NBL1_ENST00000548815.1_Missense_Mutation_p.A16V	NM_001204085.1|NM_001278164.1|NM_001278166.1	NP_001191014.1|NP_001265093.1|NP_001265095.1	P41271	NBL1_HUMAN	neuroblastoma 1, DAN family BMP antagonist	16						extracellular region				lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00043)|Ovarian(437;0.00373)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.9e-05)|Kidney(64;0.000173)|GBM - Glioblastoma multiforme(114;0.0012)|KIRC - Kidney renal clear cell carcinoma(64;0.0026)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ATGCTACTGGCTGCCCCACCA	0.627000													8	24					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26312975	26312975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26312975G>A	ENST00000265944.5	+	9	922	c.756G>A	c.(754-756)caG>caA	p.Q252Q	MYO3A_ENST00000543632.1_Silent_p.Q252Q	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	252	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AACTAAGGCAGCCTGAGCTAT	0.378000													55	141					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7720897	7720897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7720897C>T	ENST00000572933.1	+	66	11499	c.10039C>T	c.(10039-10041)Cct>Tct	p.P3347S	DNAH2_ENST00000389173.2_Missense_Mutation_p.P3347S			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3347					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCTTCAGGTTCCTTGCTCCCC	0.537000													70	63					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982672	36982672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36982672G>A	ENST00000274963.8	+	8	1058	c.887G>A	c.(886-888)cGg>cAg	p.R296Q		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	296					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						CCCTAGGAGCGGCTGCAGGAC	0.642000													18	49					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945668	72945668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72945668G>A	ENST00000311131.2	+	3	931	c.464G>A	c.(463-465)gGg>gAg	p.G155E	P2RY2_ENST00000393597.2_Missense_Mutation_p.G155E|P2RY2_ENST00000393596.2_Missense_Mutation_p.G155E	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	155					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	CGGGTGGCCGGGGCCGTGTGG	0.716000													13	69					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79108233	79108233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79108233G>A	ENST00000326724.4	-	2	148	c.124C>T	c.(124-126)Ctc>Ttc	p.L42F		NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	42						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			ACGGCGAAGAGCCCGGAGAAA	0.662000													12	25					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89619495	89619495	+	Silent	SNP	C	C	T	rs1050404		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89619495C>T	ENST00000268704.2	+	14	1903	c.1888C>T	c.(1888-1890)Ctg>Ttg	p.L630L		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	630					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GTGCATGGCCCTGGGAGGACG	0.622000													8	25					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133099443	133099443	+	Silent	SNP	G	G	A	rs138205990	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133099443G>A	ENST00000515826.1	+	3	1011	c.888G>A	c.(886-888)ggG>ggA	p.G296G	TMEM108_ENST00000393130.3_Silent_p.G296G|TMEM108_ENST00000321871.6_Silent_p.G296G|TMEM108_ENST00000508711.1_Intron			Q6UXF1	TM108_HUMAN	transmembrane protein 108	296						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GCCAAGGAGGGACACCAGATG	0.662000													17	42					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43321774	43321774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43321774G>A	ENST00000380486.3	-	12	1758	c.1517C>T	c.(1516-1518)tCg>tTg	p.S506L	C2CD2_ENST00000329623.7_Missense_Mutation_p.S351L	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	506						cytosol|extracellular region|nucleus		p.S506L(1)		endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						CTTCCGTGGCGACTTGAGTTT	0.498000													21	75					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150739141	150739141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150739141G>A	ENST00000358849.4	+	14	1804	c.1711G>A	c.(1711-1713)Gcg>Acg	p.A571T	ABCB8_ENST00000356058.4_3'UTR|ABCB8_ENST00000498578.1_Missense_Mutation_p.A571T|ABCB8_ENST00000297504.6_Missense_Mutation_p.A588T|ABCB8_ENST00000542328.1_Missense_Mutation_p.A483T	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	588	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCCCGGGAAGCGAATGCTCA	0.612000													42	52					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139938380	139938380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139938380G>A	ENST00000357560.4	-	13	1694	c.1251C>T	c.(1249-1251)gcC>gcT	p.A417A	APBB3_ENST00000412920.3_Silent_p.A415A|APBB3_ENST00000508496.2_Silent_p.A194A|APBB3_ENST00000358580.5_3'UTR|APBB3_ENST00000354402.5_Silent_p.A424A|APBB3_ENST00000356738.2_Silent_p.A422A	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	417	PID 2.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGCAGAGGCCACAAGAC	0.627000													19	50					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409163	56409163	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56409163G>A	ENST00000544374.1	-	1	784	c.756C>T	c.(754-756)ctC>ctT	p.L252L	OR5AP2_ENST00000302981.1_Silent_p.L251L			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						TGACAGCCATGAGGTAAGAGG	0.458000													28	71					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289353	107289353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107289353G>A	ENST00000277216.3	-	1	137	c.138C>T	c.(136-138)atC>atT	p.I46I		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TGCTTGCTATGATCAGAACAC	0.433000													41	95					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82131918	82131918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82131918G>A	ENST00000199936.4	+	5	1234	c.1041G>A	c.(1039-1041)tgG>tgA	p.W347*	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	347					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	CTTACTTGTGGATCTGCCTTG	0.493000													40	92					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107430033	107430033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107430033G>A	ENST00000340010.5	-	6	855	c.671C>T	c.(670-672)tCc>tTc	p.S224F	SLC26A3_ENST00000422236.2_Missense_Mutation_p.S189F	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	224					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TTTGAGTTGGGAAACCAAAAC	0.393000													4	44					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40362803	40362803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40362803G>A	ENST00000221347.6	-	32	15274	c.15267C>T	c.(15265-15267)ttC>ttT	p.F5089F		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5089						extracellular region	protein binding	p.F5089F(1)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGCGGCACAGGAAGGCTTTGT	0.657000													52	132					0	0	1	0	0
CCL23	6368	broad.mit.edu	37	17	34340942	34340942	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34340942C>T	ENST00000293280.2	-	3	214	c.144G>A	c.(142-144)tgG>tgA	p.W48*	CCL23_ENST00000591423.1_Intron	NM_005064.3	NP_005055.2	P55773	CCL23_HUMAN	chemokine (C-C motif) ligand 23	46					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding			large_intestine(2)|liver(1)|lung(2)|prostate(1)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	TCTTTCTCCTCCAGAGCACTG	0.542000													13	18					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220337666	220337666	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220337666G>A	ENST00000312358.7	+	16	4127	c.3995G>A	c.(3994-3996)tGg>tAg	p.W1332*	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1332	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCGGACCAGTGGACGGCACTG	0.647000													20	49					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7950045	7950045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7950045G>A	ENST00000309838.2	-	1	164	c.165C>T	c.(163-165)ctC>ctT	p.L55L		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGGGAACGTGGAGGCTCTGGT	0.473000													40	117					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124207135	124207135	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124207135G>A	ENST00000360013.3	+	29	4490	c.4363G>A	c.(4363-4365)Gat>Aat	p.D1455N	KALRN_ENST00000240874.3_Missense_Mutation_p.D1455N|KALRN_ENST00000460856.1_Missense_Mutation_p.D1446N	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1455	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GAAAGCCAATGATGCCATGCA	0.522000													27	56					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16895700	16895700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16895700G>A	ENST00000430580.2	-	23	3369	c.2482C>T	c.(2482-2484)Ccc>Tcc	p.P828S	NBPF1_ENST00000432949.1_Intron|NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000287968.8_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	828	NBPF 4.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GACTCCTGGGGGACTTCCTCC	0.478000													28	368					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125831637	125831637	+	Silent	SNP	G	G	A	rs139545472		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125831637G>A	ENST00000393434.2	-	19	2518	c.2169C>T	c.(2167-2169)ttC>ttT	p.F723F	ALDH1L1_ENST00000273450.3_Silent_p.F733F|ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000472186.1_Silent_p.F723F|ALDH1L1_ENST00000452905.2_Silent_p.F622F	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	723	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CTCTCCGCACGAACTCATCAT	0.572000													26	98					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96024216	96024216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96024216C>T	ENST00000297954.4	+	12	3187	c.3187C>T	c.(3187-3189)Cct>Tct	p.P1063S	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.P675S|WNK2_ENST00000349097.3_Missense_Mutation_p.P675S|WNK2_ENST00000395477.2_Missense_Mutation_p.P1063S|WNK2_ENST00000356055.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1063					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						GCCTGCCGCCCCTGAGCTCCT	0.682000													6	23					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323870	44323870	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:44323870C>T	ENST00000354250.2	+	3	817	c.748C>T	c.(748-750)Ccc>Tcc	p.P250S	NDUFV3_ENST00000460259.1_3'UTR|NDUFV3_ENST00000340344.3_Intron	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	20					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	AACCACAATGCCCAGATCTCA	0.398000													20	179					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30891955	30891955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30891955C>T	ENST00000540456.1	-	3	233	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	SEC14L4_ENST00000392772.2_5'UTR|SEC14L4_ENST00000381982.3_Missense_Mutation_p.R45Q|SEC14L4_ENST00000255858.7_Missense_Mutation_p.R45Q			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	138						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	GTCAAAGTTTCGAGCTGCAAG	0.502000													5	21					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153430423	153430423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153430423G>A	ENST00000368723.3	-	3	275	c.165C>T	c.(163-165)ctC>ctT	p.L55L	S100A7_ENST00000368722.1_Silent_p.L55L	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	55	EF-hand 2.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGACATCGGCGAGGTAATTTG	0.418000													26	100					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25449508	25449508	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25449508C>T	ENST00000424208.1	+	0	2339				SNORD115-19_ENST00000363098.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						TGGGTTGGGTCGATGATGAGA	0.517000													55	245					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81702170	81702170	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81702170C>T	ENST00000372292.3	-	4	447	c.407G>A	c.(406-408)gGc>gAc	p.G136D		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	136	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TCCTTTTGGGCCTGGCTTGCC	0.597000													19	39					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129278591	129278591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129278591C>T	ENST00000393239.1	-	32	5347	c.5169G>A	c.(5167-5169)aaG>aaA	p.K1723K	PLXND1_ENST00000324093.4_Silent_p.K1723K			Q9Y4D7	PLXD1_HUMAN	plexin D1	1723					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						TCAGAATGGCCTTGAACAGGT	0.612000													28	127					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170030620	170030620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170030620G>A	ENST00000263816.3	-	56	11108	c.10823C>T	c.(10822-10824)cCa>cTa	p.P3608L		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3608	LDL-receptor class A 28.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCAGGATTCTGGGATGCAACG	0.517000													20	43					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111195390	111195390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:111195390C>T	ENST00000262839.2	-	2	1177	c.259G>A	c.(259-261)Gag>Aag	p.E87K		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	87					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGCAGTAGCTCCATGATCTCC	0.537000													72	28					0	0	1	0	0
TSKU	25987	broad.mit.edu	37	11	76507492	76507492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76507492C>T	ENST00000527881.1	+	2	1858	c.832C>T	c.(832-834)Ctg>Ttg	p.L278L	TSKU_ENST00000333090.4_Silent_p.L278L			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	278						extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					GTTTTCAGGCCTGAGCTCCCT	0.672000													18	59					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16025627	16025627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16025627G>A	ENST00000326742.7	-	9	1195	c.1194C>T	c.(1192-1194)atC>atT	p.I398I	CYP4F11_ENST00000402119.3_Silent_p.I398I|CYP4F11_ENST00000248041.7_Silent_p.I398I			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	398					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						AACATCGGGAGATGACCGGGA	0.627000													21	126					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939636	12939636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12939636C>T	ENST00000235349.5	-	4	1236	c.1166G>A	c.(1165-1167)gGa>gAa	p.G389E		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	389										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GATGGGATTTCCACAGAAGCT	0.522000													94	286					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62542072	62542072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:62542072C>T	ENST00000430451.2	+	3	1153	c.956C>T	c.(955-957)tCc>tTc	p.S319F	RP11-355I22.5_ENST00000553990.1_lincRNA|SYT16_ENST00000446982.2_Missense_Mutation_p.S319F	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	319								p.S319C(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTTGAAGATTCCTATGCCACT	0.502000													38	130					0	0	1	0	0
TMEM74B	55321	broad.mit.edu	37	20	1161580	1161580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1161580C>T	ENST00000381894.3	-	2	1354	c.683G>A	c.(682-684)aGa>aAa	p.R228K		NM_018354.1	NP_060824.1	Q9NUR3	CT046_HUMAN	transmembrane protein 74B	228						integral to membrane	protein binding										ATTGAGCTGTCTCATGCGCAG	0.602000													37	74					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440176	40440176	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40440176C>T	ENST00000319592.4	-	4	1444	c.735G>A	c.(733-735)gtG>gtA	p.V245V	RBM47_ENST00000381793.2_Silent_p.V245V|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381795.6_Silent_p.V245V|RBM47_ENST00000514014.1_Silent_p.V207V|RBM47_ENST00000295971.7_Silent_p.V245V			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	245						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						AGAGGATCTTCACGGTCTCCA	0.617000													43	104					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22272156	22272156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22272156G>A	ENST00000594947.1	+	4	1748	c.1604G>A	c.(1603-1605)aGa>aAa	p.R535K		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R535I(1)		haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTACATAAGAGAATTCATGCT	0.363000													23	37					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116889168	116889168	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116889168G>A	ENST00000355044.3	+	5	826	c.700G>A	c.(700-702)Gaa>Aaa	p.E234K	ATRNL1_ENST00000529665.1_3'UTR|ATRNL1_ENST00000527407.1_Missense_Mutation_p.E234K	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	234	EGF-like 2.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGTATATTGTGAATGTGATAA	0.383000													13	93					0	0	1	0	0
WSCD1	23302	broad.mit.edu	37	17	6023659	6023659	+	Missense_Mutation	SNP	C	C	T	rs148765035		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6023659C>T	ENST00000574946.1	+	9	1796	c.1406C>T	c.(1405-1407)tCg>tTg	p.S469L	WSCD1_ENST00000573634.1_Missense_Mutation_p.S353L|WSCD1_ENST00000539421.1_Missense_Mutation_p.S469L|WSCD1_ENST00000317744.5_Missense_Mutation_p.S469L|WSCD1_ENST00000574232.1_Missense_Mutation_p.S469L			Q658N2	WSCD1_HUMAN	WSC domain containing 1	469						integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						AGCTACGCCTCGTGGTGGTCC	0.672000													55	80					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48678421	48678421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48678421C>T	ENST00000352832.5	+	18	4104	c.3732C>T	c.(3730-3732)ctC>ctT	p.L1244L	CACNA1G_ENST00000512389.1_Silent_p.L1267L|CACNA1G_ENST00000507336.1_Silent_p.L1267L|CACNA1G_ENST00000507609.1_Silent_p.L1267L|CACNA1G_ENST00000354983.4_Silent_p.L1244L|CACNA1G_ENST00000503485.1_Silent_p.L1267L|CACNA1G_ENST00000507896.1_Silent_p.L1267L|CACNA1G_ENST00000358244.5_Silent_p.L1244L|CACNA1G_ENST00000510115.1_Silent_p.L1244L|CACNA1G_ENST00000510366.1_Silent_p.L1267L|CACNA1G_ENST00000502264.1_Silent_p.L1244L|CACNA1G_ENST00000429973.2_Silent_p.L1267L|CACNA1G_ENST00000416767.4_Silent_p.L1267L|CACNA1G_ENST00000360761.4_Silent_p.L1244L|CACNA1G_ENST00000515765.1_Silent_p.L1267L|CACNA1G_ENST00000515411.1_Silent_p.L1267L|CACNA1G_ENST00000442258.2_Silent_p.L1244L|CACNA1G_ENST00000515165.1_Silent_p.L1267L|CACNA1G_ENST00000505165.1_Silent_p.L1267L|CACNA1G_ENST00000359106.5_Silent_p.L1267L|CACNA1G_ENST00000514717.1_Silent_p.L1244L|CACNA1G_ENST00000514181.1_Silent_p.L1267L|CACNA1G_ENST00000514079.1_Silent_p.L1267L|CACNA1G_ENST00000513964.1_Silent_p.L1267L|CACNA1G_ENST00000507510.2_Silent_p.L1267L|CACNA1G_ENST00000513689.2_Silent_p.L1267L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1267					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGTTCCGCCTCCTGTGTCACC	0.627000													55	85					0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30133195	30133195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30133195G>A	ENST00000403394.1	-	2	402	c.303C>T	c.(301-303)atC>atT	p.I101I	MAPK3_ENST00000484663.1_5'UTR|MAPK3_ENST00000395200.1_Silent_p.I72I|MAPK3_ENST00000395199.3_Silent_p.I101I|MAPK3_ENST00000322266.5_Silent_p.I101I|MAPK3_ENST00000395202.1_Silent_p.I101I|MAPK3_ENST00000263025.4_Silent_p.I101I	NM_001040056.1	NP_001035145.1	P27361	MK03_HUMAN	mitogen-activated protein kinase 3	101	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	CTCGGATGCCGATGACATTCT	0.602000													14	16					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2959084	2959084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2959084C>T	ENST00000396946.4	-	18	2835	c.2432G>A	c.(2431-2433)aGg>aAg	p.R811K		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	811					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCACTCGTGCCTGTCCTGGTA	0.607000			Mis		DLBCL								27	48					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28654823	28654823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28654823C>T	ENST00000280904.6	-	12	2157	c.1714G>A	c.(1714-1716)Gat>Aat	p.D572N	DSC2_ENST00000251081.6_Missense_Mutation_p.D572N	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	572	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GGGCTGTTATCATTCACGTCT	0.408000													19	32					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18458484	18458484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:18458484G>A	ENST00000338745.6	-	3	2032	c.298C>T	c.(298-300)Ctg>Ttg	p.L100L	SATB1_ENST00000454909.2_Silent_p.L100L|SATB1_ENST00000475083.1_5'UTR|SATB1_ENST00000417717.2_Silent_p.L100L|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	100	PDZ-like dimerization domain.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						TTTCTCACCAGCACAAATTCT	0.428000													49	127					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33464952	33464952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33464952G>A	ENST00000379471.2	-	21	2791	c.2704C>T	c.(2704-2706)Cga>Tga	p.R902*	NOL6_ENST00000455041.2_Nonsense_Mutation_p.R850*|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	902					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AAAAGGAATCGAAGGAAGCCA	0.502000													23	59					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9321515	9321515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9321515G>A	ENST00000261336.2	-	17	2085	c.2057C>T	c.(2056-2058)tCa>tTa	p.S686L	PZP_ENST00000381997.2_Missense_Mutation_p.S555L	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						AGGGATGACTGAACACGACTT	0.368000													36	86					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64556357	64556357	+	Silent	SNP	C	C	T	rs111652000		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:64556357C>T	ENST00000357395.3	+	60	12035	c.891C>T	c.(889-891)atC>atT	p.I297I	SYNE2_ENST00000358025.3_Silent_p.I3912I|SYNE2_ENST00000394768.2_Silent_p.I297I|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000554584.1_Silent_p.I3945I|SYNE2_ENST00000344113.4_Silent_p.I3912I|SYNE2_ENST00000555002.1_Silent_p.I546I			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3912					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCAAAACTATCCTATTATCAA	0.279000													27	57					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155719427	155719427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155719427C>T	ENST00000510397.1	+	3	795	c.616C>T	c.(616-618)Cca>Tca	p.P206S	RBM46_ENST00000514866.1_Missense_Mutation_p.P206S|RBM46_ENST00000281722.3_Missense_Mutation_p.P206S	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	206	RRM 2.						nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				GAAACTAATTCCAGGTAAACT	0.338000													14	55					0	0	1	0	0
LPPR1	54886	broad.mit.edu	37	9	104032305	104032305	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104032305C>T	ENST00000374874.3	+	3	646	c.207C>T	c.(205-207)acC>acT	p.T69T	LPPR1_ENST00000395056.2_Silent_p.T69T	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		69						integral to membrane	catalytic activity										GCTTCATCACCCCTCTGGTGC	0.443000													8	51					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41012157	41012157	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41012157C>T	ENST00000352632.3	+	13	1766	c.1680C>T	c.(1678-1680)tcC>tcT	p.S560S	SPTBN4_ENST00000344104.3_Silent_p.S560S|SPTBN4_ENST00000595535.1_Silent_p.S560S|SPTBN4_ENST00000598249.1_Silent_p.S560S|SPTBN4_ENST00000338932.3_Silent_p.S560S			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	560					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGCTGCTGTCCCGGGAGTGTG	0.652000													30	74					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62740730	62740730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62740730C>T	ENST00000371153.4	-	3	424	c.46G>A	c.(46-48)Gag>Aag	p.E16K	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	16										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GGGTCTTTCTCTTCATCCCCC	0.453000													28	77					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180348073	180348073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:180348073G>A	ENST00000410066.1	-	6	1199	c.596C>T	c.(595-597)cCt>cTt	p.P199L	ZNF385B_ENST00000409343.1_Missense_Mutation_p.P123L|ZNF385B_ENST00000336917.5_Missense_Mutation_p.P97L|ZNF385B_ENST00000409692.1_Missense_Mutation_p.P97L|ZNF385B_ENST00000466398.1_5'UTR	NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	199						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GTCCTTGGAAGGAACCATTTT	0.458000													5	77					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63257495	63257495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:63257495G>A	ENST00000323865.3	-	1	285	c.52C>T	c.(52-54)Ccc>Tcc	p.P18S	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	18					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GTCTCAAAGGGAGCCGGTGGT	0.622000													21	67					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25023478	25023478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25023478C>T	ENST00000400382.1	+	12	1855	c.1100C>T	c.(1099-1101)tCc>tTc	p.S367F	GGT1_ENST00000403838.1_Missense_Mutation_p.S23F|GGT1_ENST00000404223.1_Missense_Mutation_p.S23F|GGT1_ENST00000400383.1_Missense_Mutation_p.S367F|GGT1_ENST00000248923.4_Missense_Mutation_p.S367F|GGT1_ENST00000406383.2_Missense_Mutation_p.S367F|GGT1_ENST00000404920.1_Missense_Mutation_p.S23F|GGT1_ENST00000400380.1_Missense_Mutation_p.S367F|GGT1_ENST00000404532.1_Missense_Mutation_p.S23F|GGT1_ENST00000401885.1_Missense_Mutation_p.S23F|GGT1_ENST00000466310.1_3'UTR			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	367					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	CACCCGATCTCCTACTACAAG	0.637000													5	46					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202072836	202072836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202072836C>T	ENST00000360132.3	+	7	1178	c.760C>T	c.(760-762)Cct>Tct	p.P254S	CASP10_ENST00000286186.6_Silent_p.G284G|CASP10_ENST00000313728.7_Intron|CASP10_ENST00000272879.5_Silent_p.G284G|CASP10_ENST00000346817.5_Silent_p.G241G|CASP10_ENST00000448480.1_Silent_p.G241G|CASP10_ENST00000492363.1_3'UTR	NM_001206524.1|NM_001230.4|NM_032976.3	NP_001193453.1|NP_001221.2|NP_116758.1	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	0					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						ACCACAGAGGCCTCTGTGTCA	0.433000													26	56					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21119923	21119923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21119923G>A	ENST00000269228.5	-	18	3201	c.2647C>T	c.(2647-2649)Ctg>Ttg	p.L883L	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Silent_p.L565L	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	883					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCCGCATGCAGGTACTGACTG	0.483000													22	73					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504230	70504230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70504230C>T	ENST00000310961.5	+	22	3042	c.2624C>T	c.(2623-2625)cCa>cTa	p.P875L	LRRC7_ENST00000415775.2_Missense_Mutation_p.P154L|LRRC7_ENST00000035383.5_Missense_Mutation_p.P870L			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	870						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						ACTACCAGCCCATTGCCTGAA	0.468000													51	112					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448284	155448284	+	Silent	SNP	G	G	A	rs148724344		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155448284G>A	ENST00000368346.3	-	3	5016	c.4377C>T	c.(4375-4377)ccC>ccT	p.P1459P	ASH1L_ENST00000392403.3_Silent_p.P1459P			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1459					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding	p.P1459P(1)		autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TGGAAAGGAGGGGAGTCCTGC	0.478000													31	95					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99013055	99013055	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99013055G>C	ENST00000393504.1	+	8	1839	c.1422G>C	c.(1420-1422)ctG>ctC	p.L474L	CNGA3_ENST00000409937.1_Silent_p.L478L|CNGA3_ENST00000436404.2_Silent_p.L456L|CNGA3_ENST00000272602.2_Silent_p.L474L	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	474					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						ACGTGCACCTGGACACGCTGA	0.577000													5	21					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155488849	155488849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155488849C>T	ENST00000302068.4	+	4	658	c.595C>T	c.(595-597)Cgt>Tgt	p.R199C	FGB_ENST00000509493.1_5'UTR|FGB_ENST00000502545.1_3'UTR	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain	199					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding	p.R199C(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TCGTGTGCTTCGTTCAATCCT	0.393000													52	111					0	0	1	0	0
TBX1	6899	broad.mit.edu	37	22	19752564	19752564	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19752564C>T	ENST00000332710.4	+	6	897	c.768C>T	c.(766-768)gcC>gcT	p.A256A	TBX1_ENST00000359500.3_Silent_p.A256A|TBX1_ENST00000329705.7_Silent_p.A256A	NM_080647.1	NP_542378.1	O43435	TBX1_HUMAN	T-box 1	256					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|lung(3)|ovary(2)	8	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				AGAAATATGCCGAGGAGAACT	0.542000													39	102					0	0	1	0	0
POU5F1	5460	broad.mit.edu	37	6	31138004	31138004	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31138004T>A	ENST00000259915.8	-	1	466	c.394A>T	c.(394-396)Aac>Tac	p.N132Y	POU5F1_ENST00000441888.3_Intron	NM_002701.4	NP_002692.2	Q01860	PO5F1_HUMAN	POU class 5 homeobox 1	132					anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	breast(1)|large_intestine(2)|lung(3)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	13						TCCTCCGGGTTTTGCTCCAGC	0.652000			T	EWSR1	sarcoma								25	58					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145109788	145109788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145109788G>A	ENST00000426825.1	-	18	2519	c.2438C>T	c.(2437-2439)cCt>cTt	p.P813L	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	813							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CACGTCGCCAGGGTGGAGATC	0.677000													11	26					0	0	1	0	0
NEXN	91624	broad.mit.edu	37	1	78398979	78398979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:78398979G>A	ENST00000330010.8	+	9	1171	c.874G>A	c.(874-876)Gac>Aac	p.D292N	NEXN_ENST00000334785.7_Missense_Mutation_p.D356N|NEXN_ENST00000480732.1_3'UTR|NEXN_ENST00000457030.1_Missense_Mutation_p.D342N	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	356	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		AGTAGATGATGACTCCCCAGA	0.299000													4	35					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878191	150878191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150878191G>A	ENST00000422024.1	-	3	1199	c.1074C>T	c.(1072-1074)ctC>ctT	p.L358L	ASB10_ENST00000275838.1_Silent_p.L313L|ASB10_ENST00000434669.1_Silent_p.L358L|ASB10_ENST00000420175.2_Silent_p.L313L|ASB10_ENST00000377867.3_Silent_p.L298L	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	313					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACAGGACAGGAGCAGCTCCA	0.672000													4	30					0	0	1	0	0
CLSTN1	22883	broad.mit.edu	37	1	9795569	9795569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9795569G>A	ENST00000377298.4	-	13	2631	c.1839C>T	c.(1837-1839)ttC>ttT	p.F613F	CLSTN1_ENST00000361311.4_Silent_p.F603F|CLSTN1_ENST00000377288.3_Silent_p.F594F	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	613					homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		CGGGCGTGGGGAACTGCCGGG	0.507000													44	155					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41497234	41497234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41497234C>T	ENST00000324071.4	+	1	31	c.24C>T	c.(22-24)ttC>ttT	p.F8F		NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	8					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TCCTCCTCTTCCTTGCACTCC	0.622000													71	184					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173552676	173552676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173552676C>T	ENST00000367714.3	-	6	1031	c.609G>A	c.(607-609)cgG>cgA	p.R203R	SLC9C2_ENST00000536496.1_Silent_p.R101R|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	203					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										TTCTGTTGCCCCGAAAATTTC	0.279000													28	79					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94158125	94158125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94158125C>T	ENST00000553484.1	+	48	7640	c.7486C>T	c.(7486-7488)Cac>Tac	p.H2496Y	UNC79_ENST00000555664.1_Missense_Mutation_p.H2435Y|UNC79_ENST00000393151.2_Missense_Mutation_p.H2474Y|UNC79_ENST00000256339.4_Missense_Mutation_p.H2297Y			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2474						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CTCCCTCTTCCACGCGTTCAT	0.532000													30	84					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7580705	7580705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7580705G>A	ENST00000379802.3	+	23	4623	c.4282G>A	c.(4282-4284)Gaa>Aaa	p.E1428K	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1428	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAGGGTGGAAGAAGACATCCA	0.488000													19	59					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645535	45645535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:45645535C>T	ENST00000303230.4	-	2	658	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	201						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GAACTGTCTTCATTGACAGTC	0.388000													27	77					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110764629	110764629	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:110764629A>G	ENST00000451085.1	+	4	2847	c.1801A>G	c.(1801-1803)Aaa>Gaa	p.K601E	IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000450877.1_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.K601E|LRRN3_ENST00000422987.3_Missense_Mutation_p.K601E	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	601	Fibronectin type-III.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		CATCTATCAGAAAAACAGAAA	0.348000													5	58					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55418468	55418468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55418468C>T	ENST00000312422.2	+	1	89	c.89C>T	c.(88-90)tCt>tTt	p.S30F		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GTGGTGTTTTCTTTCTTCTAC	0.388000													28	117					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849489	73849489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73849489C>T	ENST00000523207.1	+	3	2487	c.1899C>T	c.(1897-1899)ttC>ttT	p.F633F		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	633					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AGATGAAGTTCCCAACCGACC	0.607000													40	114					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143793109	143793109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143793109C>T	ENST00000408949.2	+	1	969	c.909C>T	c.(907-909)gtC>gtT	p.V303V		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					TAAAGAGAGTCCTTTGGAAAC	0.438000													55	172					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088044	86088044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:86088044G>A	ENST00000330753.4	+	2	953	c.186G>A	c.(184-186)ccG>ccA	p.P62P	FLRT2_ENST00000554746.1_Silent_p.P62P	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	62	LRRNT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TTGGGATCCCGGAGGGCGTAA	0.517000													23	122					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6458118	6458118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6458118C>T	ENST00000396966.2	-	9	1512	c.1493G>A	c.(1492-1494)aGa>aAa	p.R498K	SCNN1A_ENST00000543768.1_Silent_p.K540K|SCNN1A_ENST00000358945.3_Silent_p.K539K|SCNN1A_ENST00000360168.3_Silent_p.K576K|SCNN1A_ENST00000228916.2_Silent_p.K517K|SCNN1A_ENST00000540037.1_Silent_p.K217K			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	498					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	GGACTGACCTCTTGTTGTTGA	0.488000													126	321					0	0	1	0	0
GFOD2	81577	broad.mit.edu	37	16	67709604	67709604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67709604G>A	ENST00000268797.7	-	3	957	c.612C>T	c.(610-612)ttC>ttT	p.F204F	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	204						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		TCTGCCTCACGAATGTCTTGA	0.612000													7	72					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128452782	128452782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128452782G>A	ENST00000297788.4	+	14	2929	c.2562G>A	c.(2560-2562)gtG>gtA	p.V854V	CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000487361.1_Intron|CCDC136_ENST00000464832.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	854						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						AAATGGTTGTGAAAGTGCTGA	0.577000													16	34					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126412156	126412156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126412156G>A	ENST00000394329.3	+	17	14192	c.14179G>A	c.(14179-14181)Gat>Aat	p.D4727N	FAT4_ENST00000335110.5_Missense_Mutation_p.D2968N	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4727					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCCTATAAGGGATGGTAATAC	0.493000													35	91					0	0	1	0	0
ADPRH	141	broad.mit.edu	37	3	119305206	119305206	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119305206C>T	ENST00000478399.1	+	3	1778	c.373C>T	c.(373-375)Cat>Tat	p.H125Y	ADPRH_ENST00000471850.1_3'UTR|ADPRH_ENST00000465513.1_Missense_Mutation_p.H125Y|ADPRH_ENST00000478927.1_Missense_Mutation_p.H125Y|ADPRH_ENST00000357003.3_Missense_Mutation_p.H125Y			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	125					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		CTTCAACAGCCATGAGGGCGG	0.607000													64	139					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169282328	169282328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169282328C>T	ENST00000511577.1	-	37	5210	c.4963G>A	c.(4963-4965)Gat>Aat	p.D1655N	DDX60L_ENST00000260184.7_Missense_Mutation_p.D1655N			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1655							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		AATGCAAAATCTTTCAAACAC	0.289000													5	18					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42780032	42780032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42780032C>T	ENST00000330714.3	+	14	2204	c.2020C>T	c.(2020-2022)Cgc>Tgc	p.R674C		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	674	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				GGAAAAAAATCGCTATTCCTG	0.468000													54	45					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197036305	197036305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197036305C>T	ENST00000367412.1	-	1	92	c.49G>A	c.(49-51)Gaa>Aaa	p.E17K		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	17					blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						GCATAGAGTTCTCCTGAGATT	0.284000													14	38					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226446683	226446683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:226446683G>A	ENST00000272907.6	+	4	963	c.550G>A	c.(550-552)Gat>Aat	p.D184N	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	184																	ACCCCACAGCGATGAATATTC	0.413000													17	213					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21992265	21992265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21992265C>T	ENST00000327430.3	-	2	1891	c.1597G>A	c.(1597-1599)Ggc>Agc	p.G533S	SALL2_ENST00000450879.2_Missense_Mutation_p.G396S|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	533							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		ATGGCTGAGCCCTCACTCCCT	0.517000													7	67					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118310689	118310689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118310689C>T	ENST00000369221.2	+	5	432	c.404C>T	c.(403-405)tCg>tTg	p.S135L	PNLIP_ENST00000470562.1_3'UTR	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	135					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	ACACAAGCCTCGCAGAACATC	0.463000													7	30					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200014584	200014584	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200014584G>A	ENST00000367362.3	+	4	581	c.335G>A	c.(334-336)cGa>cAa	p.R112Q	NR5A2_ENST00000236914.3_Missense_Mutation_p.R66Q|NR5A2_ENST00000544748.1_Missense_Mutation_p.R40Q	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	112					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					TTTTTTAAGCGAACAGTCCAA	0.323000													12	68					0	0	1	0	0
PDK2	5164	broad.mit.edu	37	17	48174904	48174904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48174904C>T	ENST00000503176.1	+	2	397	c.236C>T	c.(235-237)cCc>cTc	p.P79L	PDK2_ENST00000007708.3_Missense_Mutation_p.P15L	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	79					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						CTGAGCACACCCTCCGTGCAG	0.612000									Autosomal Dominant Polycystic Kidney Disease				9	37					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159514632	159514632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:159514632G>A	ENST00000307765.5	+	3	518	c.267G>A	c.(265-267)gaG>gaA	p.E89E	RXFP1_ENST00000343542.5_Silent_p.E89E|RXFP1_ENST00000423548.1_Silent_p.E89E|RXFP1_ENST00000460056.2_Silent_p.E8E|RXFP1_ENST00000470033.1_Intron|RXFP1_ENST00000448688.2_Silent_p.E8E	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	89						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		ATCCTTTTGAGGCAGAAACAC	0.313000													5	47					0	0	1	0	0
CPNE6	9362	broad.mit.edu	37	14	24546362	24546362	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24546362G>A	ENST00000397016.2	+	16	1610		c.e16-1		CPNE6_ENST00000537691.1_Splice_Site|CPNE6_ENST00000216775.2_Splice_Site			O95741	CPNE6_HUMAN	copine VI (neuronal)						lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		CTTGCCCTCAGAAGTACTCGG	0.597000													11	47					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121957874	121957874	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121957874G>A	ENST00000379692.4	-	4	1778	c.1252C>T	c.(1252-1254)Ctc>Ttc	p.L418F		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	418										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						AGTCGAACGAGGTATTTAGCT	0.423000													66	160					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39452309	39452309	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39452309C>T	ENST00000280481.7	+	22	8926	c.8710C>T	c.(8710-8712)Cag>Tag	p.Q2904*		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2904					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGATCCTGTCCAGAATCTGGG	0.398000													36	135					0	0	1	0	0
PHOX2B	8929	broad.mit.edu	37	4	41750565	41750565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41750565C>T	ENST00000226382.2	-	1	422	c.63G>A	c.(61-63)atG>atA	p.M21I	RP11-227F19.1_ENST00000508038.1_RNA	NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	21					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						TCGAGGTGTCCATCCCAGCCA	0.498000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				12	31					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39777260	39777260	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39777260G>A	ENST00000540235.1	-	8	1394	c.1395C>T	c.(1393-1395)acC>acT	p.T465T	KRT17_ENST00000311208.8_Silent_p.T306T			P14923	PLAK_HUMAN	junction plakoglobin	0					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		AGGCCTGCATGGTGCGCCGGA	0.597000													21	28					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28659862	28659862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28659862C>T	ENST00000280904.6	-	11	2057	c.1614G>A	c.(1612-1614)gaG>gaA	p.E538E	DSC2_ENST00000251081.6_Silent_p.E538E	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	538	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTTTGATGGTCTCTGCCTCTC	0.388000													19	229					0	0	1	0	0
LRRC39	127495	broad.mit.edu	37	1	100620727	100620727	+	Missense_Mutation	SNP	C	C	T	rs142389687	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100620727C>T	ENST00000370138.1	-	8	890	c.692G>A	c.(691-693)cGa>cAa	p.R231Q	LRRC39_ENST00000370137.1_Missense_Mutation_p.R231Q|LRRC39_ENST00000342895.3_Missense_Mutation_p.R231Q	NM_001256385.1	NP_001243314.1	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39	231										endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	13		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		TATTTCATTTCGTTGCAGCCA	0.308000													9	68					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123842272	123842272	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123842272G>A	ENST00000369005.1	+	4	597	c.257G>A	c.(256-258)gGa>gAa	p.G86E	TACC2_ENST00000334433.3_Missense_Mutation_p.G86E|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.G86E|TACC2_ENST00000515273.1_Missense_Mutation_p.G86E|TACC2_ENST00000453444.2_Missense_Mutation_p.G86E	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	86						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GACCCACAGGGAGCCAGGGGG	0.637000													30	88					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226446723	226446723	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:226446723G>A	ENST00000272907.6	+	4	1003	c.590G>A	c.(589-591)cGa>cAa	p.R197Q	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	197								p.R197Q(2)									AAACCGAAGCGAAATCCGAAC	0.502000													71	196					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135441522	135441522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135441522G>A	ENST00000394143.1	+	11	7343	c.7052G>A	c.(7051-7053)aGt>aAt	p.S2351N	GPR112_ENST00000370652.1_Missense_Mutation_p.S2351N|GPR112_ENST00000287534.4_Intron|GPR112_ENST00000394141.1_Missense_Mutation_p.S2146N|GPR112_ENST00000412101.1_Missense_Mutation_p.S2146N	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2351					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AAAATCAAAAGTAAAATACAT	0.338000													73	41					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115454199	115454199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115454199G>A	ENST00000369522.3	+	18	1765	c.1525G>A	c.(1525-1527)Gag>Aag	p.E509K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E509K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	509				IQLTAITTSEQYYSKEVKDLKTELENEK -> YSYCHYHKW TVLPKRGQRPKLSSKRE (in Ref. 2; BAA22586).	cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTTGAAAACGAGAAGTATGT	0.249000													12	29					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1914014	1914014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1914014G>A	ENST00000399161.2	-	13	2562	c.1815C>T	c.(1813-1815)ctC>ctT	p.L605L	MYT1L_ENST00000428368.2_Silent_p.L603L	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	605					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGGGTACCTGAGCACGCGGT	0.637000													26	27					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45681059	45681059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45681059G>A	ENST00000270172.3	-	2	567	c.84C>T	c.(82-84)tcC>tcT	p.S28S	DNMT3L_ENST00000418993.1_Silent_p.S28S	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	28					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		CGGGTGAAACGGAGCTTGAGA	0.602000													36	83					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101566311	101566311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101566311G>A	ENST00000284395.5	+	18	2765	c.2365G>A	c.(2365-2367)Ggc>Agc	p.G789S	LRRK1_ENST00000388948.3_Missense_Mutation_p.G792S			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	792	Roc.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CAGGGCCACAGGCTTCCCAGA	0.582000													12	64					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73615104	73615104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73615104C>T	ENST00000261917.3	-	8	4323	c.3330G>A	c.(3328-3330)ggG>ggA	p.G1110G		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	1110					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		CCATGGACTCCCCTGAGGAGT	0.721000													4	4					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99800311	99800311	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:99800311G>A	ENST00000259470.5	-	2	264	c.15C>T	c.(13-15)ctC>ctT	p.L5L	CTSV_ENST00000538255.1_Silent_p.L5L|CTSV_ENST00000479932.1_5'UTR	NM_001333.3	NP_001324.2			cathepsin V																		CAGCCAGGACGAGCGAAAGAT	0.418000													24	68					0	0	1	0	0
FAM217B	63939	broad.mit.edu	37	20	58519433	58519433	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58519433C>T	ENST00000358293.3	+	5	850	c.435C>T	c.(433-435)ttC>ttT	p.F145F	FAM217B_ENST00000469084.1_Intron|FAM217B_ENST00000360816.3_Silent_p.F145F	NM_001190826.1	NP_001177755.1	Q9NTX9	CT177_HUMAN	family with sequence similarity 217, member B	145																	ATCCTAATTTCCTTCCATCCC	0.483000													8	101					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57422542	57422542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57422542C>T	ENST00000543257.1	-	4	701	c.135G>A	c.(133-135)ggG>ggA	p.G45G	C8B_ENST00000371237.4_Silent_p.G97G|C8B_ENST00000535057.1_Silent_p.G35G	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	97					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGCACGGTTCCCCATGGAACT	0.522000													42	167					0	0	1	0	0
TBC1D21	161514	broad.mit.edu	37	15	74174023	74174023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74174023C>T	ENST00000300504.2	+	3	290	c.207C>T	c.(205-207)ttC>ttT	p.F69F	TBC1D21_ENST00000535547.2_Silent_p.F33F|TBC1D21_ENST00000562056.1_Silent_p.F69F	NM_153356.1	NP_699187.1	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	69	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	17						CCTGGAAATTCCTCACGGGCT	0.597000													13	48					0	0	1	0	0
CA9	768	broad.mit.edu	37	9	35675537	35675537	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35675537G>A	ENST00000378357.4	+	2	510	c.406G>A	c.(406-408)Gat>Aat	p.D136N		NM_001216.2	NP_001207.2	Q16790	CAH9_HUMAN	carbonic anhydrase IX	136	Catalytic.				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	17	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TTATACAGGGGATGACCAGAG	0.547000													10	47					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2610032	2610032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2610032C>T	ENST00000155840.5	+	10	1449	c.1341C>T	c.(1339-1341)ccC>ccT	p.P447P	KCNQ1_ENST00000335475.5_Silent_p.P320P	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	447					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CGTGCGACCCCCCAGAAGAGC	0.552000													9	31					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870051	4870051	+	Missense_Mutation	SNP	G	G	A	rs139421041		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4870051G>A	ENST00000322101.2	-	1	463	c.388C>T	c.(388-390)Cgg>Tgg	p.R130W	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R130W(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCAGTGCCCGATCAATGGAC	0.522000													45	99					0	0	1	0	0
STYXL1	51657	broad.mit.edu	37	7	75634657	75634657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:75634657G>A	ENST00000451157.1	-	6	688	c.519C>T	c.(517-519)ttC>ttT	p.F173F	STYXL1_ENST00000248600.1_Silent_p.F173F|STYXL1_ENST00000431581.1_Silent_p.F173F|STYXL1_ENST00000340062.5_Silent_p.F77F|STYXL1_ENST00000360591.3_3'UTR|STYXL1_ENST00000359697.3_Silent_p.F173F			Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	173	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						AGGCTTGACTGAAATTGCCAA	0.468000													33	87					0	0	1	0	0
MYL10	93408	broad.mit.edu	37	7	101265448	101265448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101265448C>T	ENST00000223167.4	-	5	559	c.382G>A	c.(382-384)Gcc>Acc	p.A128T		NM_138403.4	NP_612412.2	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	128						mitochondrion	calcium ion binding			breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	12						TTCACCATGGCCTCCAGTTCC	0.602000													10	54					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104057386	104057386	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104057386G>T	ENST00000265148.3	-	40	6523	c.6434C>A	c.(6433-6435)cCc>cAc	p.P2145H	CENPE_ENST00000380026.3_Missense_Mutation_p.P2024H	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2145	Kinetochore-binding domain.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTGTAAATAGGGAAGTGAGAG	0.358000													47	105					1.06522e-23	1.07221e-23	1	1	0
ELF3	1999	broad.mit.edu	37	1	201983066	201983066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201983066C>T	ENST00000359651.3	+	7	4107	c.915C>T	c.(913-915)ttC>ttT	p.F305F	ELF3_ENST00000367283.3_Silent_p.F305F|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367284.5_Silent_p.F305F			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	305					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.L306fs*19(2)		breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						TCTTCAAGTTCCTGCGCTCCG	0.592000													5	27					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40113039	40113039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40113039G>A	ENST00000373233.3	-	15	2387	c.2210C>T	c.(2209-2211)aCc>aTc	p.T737I	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	737					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CTCCATCATGGTGTTGATGAG	0.493000													58	163					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65456139	65456139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:65456139C>T	ENST00000330909.8	-	5	777	c.778G>A	c.(778-780)Gag>Aag	p.E260K	MAGI1_ENST00000497477.2_Missense_Mutation_p.E260K|MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000402939.2_Missense_Mutation_p.E260K|MAGI1_ENST00000483466.1_Missense_Mutation_p.E260K	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	260	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		AGAGTGTGCTCCTCTTGTTCA	0.458000													14	81					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128987836	128987836	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:128987836C>T	ENST00000314797.6	+	18	1940	c.1836C>T	c.(1834-1836)atC>atT	p.I612I		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	612	Interaction with ZNF289/ARFGAP2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										GGCAGGAGATCTTCCAGGGTG	0.512000													24	85					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36330297	36330297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36330297C>T	ENST00000378910.5	-	22	2950	c.2951G>A	c.(2950-2952)gGg>gAg	p.G984E	NPHS1_ENST00000353632.6_Missense_Mutation_p.G984E	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	984	Fibronectin type-III.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATAGTGGAACCCTGGAGTCCC	0.577000													19	62					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169509663	169509663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169509663C>T	ENST00000367796.3	-	13	4881	c.4680G>A	c.(4678-4680)agG>agA	p.R1560R	F5_ENST00000367797.3_Silent_p.R1555R			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1555	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGATGTTTGTCCTAACATCAG	0.418000													29	47					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11102947	11102947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11102947G>A	ENST00000400897.3	-	6	889	c.874C>T	c.(874-876)Cac>Tac	p.H292Y		NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2	292	CUB 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CTCGTGTAGTGGATCTTCCAG	0.532000													42	92					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88584064	88584064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88584064G>A	ENST00000339673.6	+	6	1233	c.1134G>A	c.(1132-1134)caG>caA	p.Q378Q	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Silent_p.Q362Q|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	378					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		TAGAAGACCAGGAAGACAGTG	0.532000													50	167					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559623	44559623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44559623C>T	ENST00000332567.4	-	1	2365	c.2013G>A	c.(2011-2013)gaG>gaA	p.E671E	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	671					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CTGGCTTGATCTCCCCATTTT	0.582000													35	96					0	0	1	0	0
TM7SF3	51768	broad.mit.edu	37	12	27143469	27143469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:27143469G>A	ENST00000343028.4	-	6	1007	c.782C>T	c.(781-783)cCg>cTg	p.P261L	TM7SF3_ENST00000542667.1_Intron	NM_016551.2	NP_057635.1	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3	261						integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	18	Colorectal(261;0.0847)					ATTTAGAAACGGGTCCCAAAC	0.483000													25	92					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132307179	132307179	+	Missense_Mutation	SNP	C	C	T	rs148167692		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:132307179C>T	ENST00000331898.7	-	4	1179	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K	OPCML_ENST00000529038.1_5'UTR|OPCML_ENST00000541867.1_Missense_Mutation_p.E201K|OPCML_ENST00000524381.1_Missense_Mutation_p.E194K|OPCML_ENST00000374778.4_Missense_Mutation_p.E160K	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	201	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity	p.E201K(2)|p.E201Q(1)|p.E194Q(1)		endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GCGCTGCATTCGTACTCCCCG	0.532000													11	63					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765989	77765989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77765989C>T	ENST00000521891.2	+	10	7280	c.6832C>T	c.(6832-6834)Cgt>Tgt	p.R2278C	ZFHX4_ENST00000050961.6_Missense_Mutation_p.R2233C|ZFHX4_ENST00000455469.2_Missense_Mutation_p.R2233C|ZFHX4_ENST00000518282.1_Missense_Mutation_p.R2252C	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2233						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAGAATGCTCGTCAGAAAGC	0.388000										HNSCC(33;0.089)			7	27					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157740417	157740417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157740417C>T	ENST00000361516.3	-	3	140	c.92G>A	c.(91-93)gGa>gAa	p.G31E	FCRL2_ENST00000368181.4_Missense_Mutation_p.G31E|FCRL2_ENST00000392274.3_Missense_Mutation_p.G31E	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	31	Ig-like C2-type 1.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GATGCTGTCTCCTTCGAAGAC	0.453000													6	52					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35617264	35617264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35617264G>A	ENST00000392225.3	-	7	1805	c.1286C>T	c.(1285-1287)tCc>tTc	p.S429F	LGI4_ENST00000493050.1_5'UTR|LGI4_ENST00000310123.3_Silent_p.I403I			Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	0						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			CGGCCTCGGGGATGTCTGTGC	0.667000													5	12					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192545481	192545481	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:192545481C>T	ENST00000367459.3	+	2	270	c.204C>T	c.(202-204)tcC>tcT	p.S68S	RGS1_ENST00000469578.2_Silent_p.S68S	NM_002922.3	NP_002913.3	Q08116	RGS1_HUMAN	regulator of G-protein signaling 1	68					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			kidney(8)|large_intestine(1)|lung(13)	22		Breast(1374;0.188)				TGAAATCTTCCAAGTCCAAGG	0.343000													19	50					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701424	56701424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56701424G>A	ENST00000586855.2	-	5	1573	c.1260C>T	c.(1258-1260)ttC>ttT	p.F420F	ZSCAN5B_ENST00000358992.3_Silent_p.F420F			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	420					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ACTCGTGGGCGAACCGCTTTT	0.567000													20	55					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7260984	7260984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7260984G>A	ENST00000266542.4	-	2	255	c.163C>T	c.(163-165)Ccc>Tcc	p.P55S	C1RL_ENST00000545337.1_Missense_Mutation_p.P55S|C1RL_ENST00000544702.1_Missense_Mutation_p.P55S|C1RL-AS1_ENST00000435921.2_RNA|C1RL_ENST00000545280.1_Intron|C1RL-AS1_ENST00000541775.1_RNA	NM_016546.2	NP_057630.2	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	55	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGGTACCCGGGGGATGTCAGC	0.622000													22	50					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858544	9858544	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9858544C>G	ENST00000396573.2	-	14	3166	c.2857G>C	c.(2857-2859)Gag>Cag	p.E953Q	GRIN2A_ENST00000404927.2_Missense_Mutation_p.E953Q|GRIN2A_ENST00000562109.1_Missense_Mutation_p.E953Q|GRIN2A_ENST00000330684.3_Missense_Mutation_p.E953Q|GRIN2A_ENST00000396575.2_Missense_Mutation_p.E953Q|GRIN2A_ENST00000535259.1_Missense_Mutation_p.E796Q	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	953					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAAATGCTCTCTTTCCCCTGA	0.443000													14	164					0	0	1	0	0
RNF220	55182	broad.mit.edu	37	1	45079881	45079881	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:45079881T>C	ENST00000355387.2	+	3	1120	c.670T>C	c.(670-672)Tgc>Cgc	p.C224R	RNF220_ENST00000443020.2_5'UTR|RNF220_ENST00000372247.2_Missense_Mutation_p.C224R|RNF220_ENST00000361799.2_Missense_Mutation_p.C224R			Q5VTB9	RN220_HUMAN	ring finger protein 220	224					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						GGCCCCAATTTGCCCCATCTG	0.587000													33	94					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531165	92531165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92531165C>T	ENST00000298047.6	+	9	5003	c.4986C>T	c.(4984-4986)acC>acT	p.T1662T	FAT3_ENST00000409404.2_Silent_p.T1662T|FAT3_ENST00000525166.1_Silent_p.T1512T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1662	Cadherin 15.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTCCGTCACCATGTCTGACA	0.448000										TCGA Ovarian(4;0.039)			33	58					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36872640	36872640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36872640C>T	ENST00000301807.6	-	21	8549	c.6652G>A	c.(6652-6654)Gag>Aag	p.E2218K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E2768K|TRANK1_ENST00000428977.2_Missense_Mutation_p.E2218K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2768					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CTGTTCCTCTCCTGACACTCC	0.537000													44	84					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123971151	123971151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123971151C>T	ENST00000369005.1	+	9	7551	c.7211C>T	c.(7210-7212)gCt>gTt	p.A2404V	TACC2_ENST00000334433.3_Missense_Mutation_p.A2404V|TACC2_ENST00000358010.1_Missense_Mutation_p.A550V|TACC2_ENST00000369004.3_Missense_Mutation_p.A482V|TACC2_ENST00000513429.1_Missense_Mutation_p.A550V|TACC2_ENST00000369001.1_Missense_Mutation_p.A108V|TACC2_ENST00000369000.1_Missense_Mutation_p.A108V|TACC2_ENST00000515603.1_Missense_Mutation_p.A2359V|TACC2_ENST00000360561.3_Missense_Mutation_p.A482V|TACC2_ENST00000368999.1_Missense_Mutation_p.A482V|TACC2_ENST00000260733.3_Missense_Mutation_p.A482V|TACC2_ENST00000515273.1_Missense_Mutation_p.A2408V|TACC2_ENST00000453444.2_Missense_Mutation_p.A2408V	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2404						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCAGCCAGTGCTATGGAAGCC	0.542000													25	94					0	0	1	0	0
SEC61A1	29927	broad.mit.edu	37	3	127783766	127783766	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127783766C>T	ENST00000243253.3	+	8	847	c.663C>T	c.(661-663)gcC>gcT	p.A221A	SEC61A1_ENST00000424880.2_Silent_p.A101A|RUVBL1_ENST00000464873.1_3'UTR|SEC61A1_ENST00000483956.1_3'UTR|SEC61A1_ENST00000464451.1_Silent_p.A227A	NM_013336.3	NP_037468.1	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit (S. cerevisiae)	221					protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|prostate(4)	21						ATCTGCTGGCCACACGCACAG	0.507000													23	102					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683765	159683765	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159683765C>T	ENST00000255030.5	-	2	328	c.225G>A	c.(223-225)aaG>aaA	p.K75K	CRP_ENST00000368111.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000368110.1_Intron|CRP_ENST00000437342.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	75	Pentaxin.			YSIFSYATKRQDNEIL -> TVFSRMPPRDKTMRFF (in Ref. 4; CAA39671).	acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	TGTCTTGTCTCTTGGTGGCAT	0.453000													24	84					0	0	1	0	0
SS18	6760	broad.mit.edu	37	18	23615043	23615043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:23615043G>A	ENST00000415083.2	-	9	1077	c.1022C>T	c.(1021-1023)cCa>cTa	p.P341L	SS18_ENST00000545952.1_Missense_Mutation_p.P258L|SS18_ENST00000542743.1_Missense_Mutation_p.P258L|SS18_ENST00000539849.1_Missense_Mutation_p.P259L|SS18_ENST00000542420.2_Missense_Mutation_p.P318L|SS18_ENST00000269137.7_Missense_Mutation_p.P310L	NM_001007559.1|NM_005637.2	NP_001007560.1|NP_005628.2	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	341	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX2(706)|SS18/SSX1(1169)|SS18/SSX4(12)	endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(1)	19	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					TCCCTGTTGTGGAGGTGGTCC	0.473000			T	"""SSX1,  SSX2"""	synovial sarcoma								13	104					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210857425	210857425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210857425C>T	ENST00000367007.4	-	11	2256	c.2087G>A	c.(2086-2088)cGa>cAa	p.R696Q	KCNH1_ENST00000271751.4_Missense_Mutation_p.R723Q	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	723	Calmodulin-binding.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity	p.R723Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTCATTCTTTCGTTTCATGCG	0.552000													16	55					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55139748	55139748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55139748C>T	ENST00000257290.5	+	10	1740	c.1409C>T	c.(1408-1410)tCa>tTa	p.S470L	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	470	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AACAATGTCTCAAACATCATC	0.502000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			23	87					0	0	1	0	0
PROK1	84432	broad.mit.edu	37	1	110998924	110998924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110998924C>T	ENST00000271331.3	+	3	286	c.269C>T	c.(268-270)cCg>cTg	p.P90L		NM_032414.2	NP_115790.1	P58294	PROK1_HUMAN	prokineticin 1	90					angiogenesis|positive regulation of cell division	extracellular region	growth factor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|skin(1)|stomach(1)	9		all_cancers(81;6.23e-06)|all_epithelial(167;2.12e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0239)|all cancers(265;0.0699)|Epithelial(280;0.0753)|Colorectal(144;0.105)|LUSC - Lung squamous cell carcinoma(189;0.135)		TCCAGGTTCCCGGACGGCAGG	0.542000													30	69					0	0	1	0	0
GSTM5	2949	broad.mit.edu	37	1	110256060	110256060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110256060G>A	ENST00000369813.1	+	2	914	c.9G>A	c.(7-9)ggG>ggA	p.G3G	GSTM5_ENST00000369812.5_Silent_p.G63G|GSTM5_ENST00000256593.3_Intron			P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	0	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			NS(1)|central_nervous_system(6)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	21		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	GGATGCTGGGGAGCCTGGTGG	0.557000													32	96					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78647165	78647165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:78647165G>A	ENST00000286627.5	-	27	4348	c.3396C>T	c.(3394-3396)tcC>tcT	p.S1132S	KCNMA1_ENST00000404857.1_Silent_p.S1173S|KCNMA1_ENST00000372443.1_Silent_p.S1159S|KCNMA1_ENST00000286628.8_Silent_p.S1190S|KCNMA1_ENST00000372440.1_Silent_p.S1132S|KCNMA1_ENST00000354353.5_Silent_p.S1193S|KCNMA1_ENST00000406533.3_Silent_p.S1194S|KCNMA1_ENST00000404771.3_Silent_p.S1190S	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	1190					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GGGAGGAATGGGACAGGCTGG	0.587000													22	59					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	98996696	98996696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98996696G>A	ENST00000393504.1	+	4	691	c.274G>A	c.(274-276)Gac>Aac	p.D92N	CNGA3_ENST00000409937.1_Missense_Mutation_p.D96N|CNGA3_ENST00000436404.2_Missense_Mutation_p.D92N|CNGA3_ENST00000272602.2_Missense_Mutation_p.D92N	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	92					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						GCACCACCAGGACCAGGGACC	0.592000													32	96					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11951662	11951662	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:11951662C>T	ENST00000339865.5	+	12	2149	c.1386C>T	c.(1384-1386)ttC>ttT	p.F462F	USP47_ENST00000539466.1_5'UTR|USP47_ENST00000399455.2_Silent_p.F550F|USP47_ENST00000527733.1_Silent_p.F530F	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	550					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		CTAGTGCTTTCGCAAGGTAAG	0.318000													12	70					0	0	1	0	0
TMEM213	155006	broad.mit.edu	37	7	138487709	138487709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138487709C>T	ENST00000442682.2	+	3	372	c.219C>T	c.(217-219)atC>atT	p.I73I	TMEM213_ENST00000413208.1_Intron|TMEM213_ENST00000458494.1_Silent_p.I49I|TMEM213_ENST00000422794.2_Silent_p.I123I|TMEM213_ENST00000397602.3_Silent_p.I72I	NM_001085429.1	NP_001078898.1	A2RRL7	TM213_HUMAN	transmembrane protein 213	73						integral to membrane		p.I73I(2)		breast(1)|endometrium(3)|kidney(1)|lung(1)	6						ACGGCTGGATCGCGGCAGCTG	0.607000													9	34					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500527	90500527	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90500527G>A	ENST00000325643.5	+	4	1191	c.1125G>A	c.(1123-1125)atG>atA	p.M375I		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GAGCACTGATGAAGATGTGGC	0.562000													40	55					0	0	1	0	0
FA2H	79152	broad.mit.edu	37	16	74750319	74750319	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:74750319G>A	ENST00000219368.3	-	6	1034	c.965C>T	c.(964-966)tCg>tTg	p.S322L	FA2H_ENST00000544337.1_Missense_Mutation_p.S109L	NM_024306.4	NP_077282.3	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	322					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						CTTGTGCGGCGAGCCAAAGTG	0.602000													23	33					0	0	1	0	0
TMEM63A	9725	broad.mit.edu	37	1	226065251	226065251	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226065251C>A	ENST00000366835.3	-	3	300	c.30G>T	c.(28-30)tgG>tgT	p.W10C		NM_014698.2	NP_055513.2	O94886	TM63A_HUMAN	transmembrane protein 63A	10						integral to membrane|lysosomal membrane	nucleotide binding			breast(2)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24	Breast(184;0.197)					CCTTGGACTGCCACAGCTCCA	0.592000											OREG0014291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	40					6.42651e-13	6.45819e-13	1	1	0
PCSK6	5046	broad.mit.edu	37	15	101865230	101865230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101865230G>A	ENST00000348070.1	-	18	2198	c.2199C>T	c.(2197-2199)ccC>ccT	p.P733P	PCSK6_ENST00000561177.1_5'UTR|PCSK6_ENST00000358417.3_Silent_p.P720P	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	734	CRM (Cys-rich motif).				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGTAGCCCAAGGGGCACACAC	0.637000													5	38					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17559460	17559460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17559460C>T	ENST00000375471.4	+	11	1400	c.1308C>T	c.(1306-1308)ttC>ttT	p.F436F		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	436					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	GGAGCAGCTTCCCCAAGTGAG	0.657000													9	11					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35541110	35541110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:35541110G>A	ENST00000287272.2	+	5	636	c.616G>A	c.(616-618)Gag>Aag	p.E206K	UNC5D_ENST00000416672.1_Missense_Mutation_p.E206K|UNC5D_ENST00000420357.1_Missense_Mutation_p.E206K|UNC5D_ENST00000404895.2_Missense_Mutation_p.E206K|UNC5D_ENST00000453357.2_Missense_Mutation_p.E201K			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	206	Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGAACAAGACGAGAACATTGA	0.458000													10	55					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61611571	61611571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61611571C>T	ENST00000583023.1	+	5	1011	c.1000C>T	c.(1000-1002)Ccc>Tcc	p.P334S	KCNH6_ENST00000314672.5_Missense_Mutation_p.P334S|KCNH6_ENST00000580652.1_Missense_Mutation_p.P334S|KCNH6_ENST00000456941.2_Missense_Mutation_p.P334S|KCNH6_ENST00000581784.1_Missense_Mutation_p.P334S	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	334					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GGTCAGCCACCCCCGCCGCAT	0.567000													32	56					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98849634	98849634	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:98849634C>T	ENST00000554295.1	-	0	1289					NR_033801.1																						GCGCCAGGATCATGCAGGAGA	0.478000													14	70					0	0	1	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125231419	125231419	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:125231419G>A	ENST00000439075.1	-	0	3326					NR_026876.1																						AATTTGTTATGAAATTGGAGC	0.308000													6	12					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96106999	96106999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:96106999C>T	ENST00000343702.4	-	4	1430	c.982G>A	c.(982-984)Gag>Aag	p.E328K	NTN4_ENST00000538383.1_Missense_Mutation_p.E291K|NTN4_ENST00000553059.1_Missense_Mutation_p.E328K|NTN4_ENST00000344911.4_Missense_Mutation_p.E291K	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	328	Laminin EGF-like 1.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						CTTCTGCACTCGTTGGGAGCC	0.502000													20	65					0	0	1	0	0
TRAV5	28688	broad.mit.edu	37	14	22217766	22217766	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22217766C>T	ENST00000390427.3	+	0	129																											GAGACAGCTCCGTTATAAACT	0.463000													11	35					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42045550	42045550	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42045550G>A	ENST00000372584.1	-	3	5933	c.4919C>T	c.(4918-4920)cCg>cTg	p.P1640L	HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1640L|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1640L|HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1640L	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1640					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGAAACCCCCGGAAGGTTGGG	0.488000													38	62					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170610362	170610362	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:170610362C>T	ENST00000523189.1	+	18	2130	c.1966C>T	c.(1966-1968)Cat>Tat	p.H656Y	RANBP17_ENST00000521759.1_3'UTR	NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	656					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGTGACAATCATAGTCTCAG	0.388000			T	TRD@	ALL								31	70					0	0	1	0	0
HLA-DPB1	3115	broad.mit.edu	37	6	33052914	33052914	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33052914C>T	ENST00000418931.2	+	3	668	c.552C>T	c.(550-552)atC>atT	p.I184I		NM_002121.5	NP_002112.3	P04440	DPB1_HUMAN	major histocompatibility complex, class II, DP beta 1	184	Beta-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex				cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	11						CCTTCCAGATCCTGGTGATGC	0.562000													38	104					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78369177	78369177	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78369177C>T	ENST00000278550.7	-	34	8698	c.8236G>A	c.(8236-8238)Gag>Aag	p.E2746K		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4									p.E2746*(2)									GGGTACTGCTCGACAGAGATC	0.597000													85	210					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111216202	111216202	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111216202G>A	ENST00000369769.2	-	1	1453	c.1230C>T	c.(1228-1230)atC>atT	p.I410I		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	410						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGAGAAAAGGATGACCCCAA	0.577000													18	59					0	0	1	0	0
TOP1	7150	broad.mit.edu	37	20	39729862	39729862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39729862C>T	ENST00000361337.2	+	13	1427	c.1177C>T	c.(1177-1179)Cct>Tct	p.P393S	RP1-1J6.2_ENST00000454626.1_RNA	NM_003286.2	NP_003277.1	P11387	TOP1_HUMAN	topoisomerase (DNA) I	393					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	TGCCAAGGTTCCTTCTCCTCC	0.443000			T	NUP98	AML*								50	72					0	0	1	0	0
TMEM98	26022	broad.mit.edu	37	17	31261321	31261321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:31261321C>T	ENST00000579849.1	+	5	707	c.276C>T	c.(274-276)tcC>tcT	p.S92S	TMEM98_ENST00000394642.3_Silent_p.S92S|TMEM98_ENST00000578289.1_Silent_p.S92S	NM_015544.2	NP_056359.2	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	92						endoplasmic reticulum|integral to membrane				kidney(2)|large_intestine(1)	3		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			GTCTCATGTCCCACTGCATTG	0.537000													7	56					0	0	1	0	0
WWOX	51741	broad.mit.edu	37	16	78458888	78458888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:78458888C>T	ENST00000566780.1	+	7	1093	c.727C>T	c.(727-729)Ctc>Ttc	p.L243F	WWOX_ENST00000408984.3_Missense_Mutation_p.L243F|WWOX_ENST00000402655.2_Intron|WWOX_ENST00000406884.2_Intron|WWOX_ENST00000539474.2_Intron	NM_016373.2	NP_057457.1	Q9NZC7	WWOX_HUMAN	WW domain containing oxidoreductase	243	Interaction with MAPT (By similarity).|Mediates targeting to the mitochondria (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	7		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		TGTCCAGCTCCTCCAGGATGT	0.517000													53	159					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18332967	18332967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18332967G>A	ENST00000355502.3	-	6	1280	c.409C>T	c.(409-411)Cgg>Tgg	p.R137W	PDE4C_ENST00000594617.2_Missense_Mutation_p.R137W|PDE4C_ENST00000262805.11_Missense_Mutation_p.R105W|PDE4C_ENST00000594465.2_Missense_Mutation_p.R137W|PDE4C_ENST00000447275.2_Missense_Mutation_p.R31W			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	137					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GAGGAGTTCCGAGACATGGCC	0.607000													23	30					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368095	18368095	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18368095G>A	ENST00000392413.3	-	4	4214	c.3999C>T	c.(3997-3999)acC>acT	p.T1333T	KIAA1683_ENST00000600328.2_Silent_p.T1146T|KIAA1683_ENST00000600359.2_Silent_p.T1100T	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	136						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GGCCTCGCCAGGTGGCTTGAA	0.612000													4	59					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824044	54824044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:54824044G>A	ENST00000243911.2	+	1	257	c.145G>A	c.(145-147)Ggc>Agc	p.G49S		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	86					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding	p.G86R(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			CCTGTCTCTGGGCATCGTCAG	0.567000													23	137					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47361637	47361637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47361637G>A	ENST00000396220.1	-	3	361	c.339C>T	c.(337-339)ttC>ttT	p.F113F	PREX1_ENST00000371941.3_Silent_p.F113F			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	113	DH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AGGCGGCCAAGAAATCCTTAT	0.502000													21	268					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45878105	45878105	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45878105G>A	ENST00000374391.2	+	2	378	c.325G>A	c.(325-327)Gag>Aag	p.E109K	ALOX5_ENST00000542434.1_Missense_Mutation_p.E109K	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	109	PLAT.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CGGCGATGTCGAGGTTGTCCT	0.592000													3	11					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161025734	161025734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:161025734G>A	ENST00000283249.2	-	7	1243	c.1006C>T	c.(1006-1008)Cat>Tat	p.H336Y	ITGB6_ENST00000428609.2_Missense_Mutation_p.H294Y|ITGB6_ENST00000409967.2_Missense_Mutation_p.H336Y|ITGB6_ENST00000485635.1_5'UTR|ITGB6_ENST00000409872.1_Missense_Mutation_p.H336Y			P18564	ITB6_HUMAN	integrin, beta 6	336	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						TCATATAAATGAACTTGTTCT	0.323000													32	83					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10425540	10425540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10425540C>T	ENST00000377086.1	+	43	4788	c.4586C>T	c.(4585-4587)tCg>tTg	p.S1529L	KIF1B_ENST00000377081.1_Missense_Mutation_p.S1529L|KIF1B_ENST00000263934.6_Missense_Mutation_p.S1483L			O60333	KIF1B_HUMAN	kinesin family member 1B	1529					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CTGAGCGACTCGTTATCCCCC	0.527000													7	85					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25543330	25543330	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:25543330G>A	ENST00000269141.3	-	15	2928	c.2505C>T	c.(2503-2505)ttC>ttT	p.F835F	CDH2_ENST00000399380.3_Silent_p.F804F|AC015933.2_ENST00000423367.1_RNA	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	835					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCTCATTAATGAAGTCCCCAA	0.488000													9	29					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125872343	125872343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125872343G>A	ENST00000393434.2	-	7	1151	c.802C>T	c.(802-804)Cgg>Tgg	p.R268W	ALDH1L1_ENST00000273450.3_Missense_Mutation_p.R278W|ALDH1L1_ENST00000393431.2_Missense_Mutation_p.R268W|ALDH1L1_ENST00000472186.1_Missense_Mutation_p.R268W|ALDH1L1_ENST00000452905.2_Missense_Mutation_p.R167W|ALDH1L1_ENST00000455064.2_Missense_Mutation_p.R93W|ALDH1L1_ENST00000413612.1_5'UTR	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	268					10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	ACCCCTGGCCGATGGGCTCCT	0.542000													31	71					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71747982	71747982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71747982G>A	ENST00000258104.3	+	11	1278	c.1001G>A	c.(1000-1002)aGa>aAa	p.R334K	DYSF_ENST00000394120.2_Missense_Mutation_p.R335K|DYSF_ENST00000409744.1_Missense_Mutation_p.R335K|DYSF_ENST00000410020.3_Missense_Mutation_p.R366K|DYSF_ENST00000413539.2_Missense_Mutation_p.R365K|DYSF_ENST00000429174.2_Missense_Mutation_p.R334K|DYSF_ENST00000409366.1_Missense_Mutation_p.R335K|DYSF_ENST00000409582.3_Missense_Mutation_p.R365K|DYSF_ENST00000409762.1_Missense_Mutation_p.R365K|DYSF_ENST00000409651.1_Missense_Mutation_p.R366K|DYSF_ENST00000410041.1_Missense_Mutation_p.R366K	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	334						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GCTGGGGCCAGAGGCTACCTG	0.572000													27	92					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11607595	11607595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11607595G>A	ENST00000262442.3	+	25	5295	c.5227G>A	c.(5227-5229)Gag>Aag	p.E1743K	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1743K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1743	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGAAGGCTATGAGAGTGCCAT	0.527000													27	43					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45459056	45459056	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45459056C>T	ENST00000548424.1	+	0	448																											AATTGGAGTTCGTTTCCTTCC	0.443000													13	26					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235969221	235969221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:235969221G>A	ENST00000389794.3	-	6	3389	c.3215C>T	c.(3214-3216)tCc>tTc	p.S1072F	LYST_ENST00000389793.2_Missense_Mutation_p.S1072F|LYST_ENST00000536965.1_Missense_Mutation_p.S1072F			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1072					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CACATTTATGGAAGAAATATG	0.383000													43	65					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183976274	183976274	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183976274C>T	ENST00000324557.4	+	3	724	c.679C>T	c.(679-681)Caa>Taa	p.Q227*	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000402825.3_Intron	NM_032331.3	NP_115707.2	O60344	ECE2_HUMAN	endothelin converting enzyme 2	0	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTGGGGGCCCAAATCCTCTC	0.582000													40	128					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834479	125834479	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125834479G>A	ENST00000299308.3	+	2	542	c.534G>A	c.(532-534)ggG>ggA	p.G178G	TMEM132B_ENST00000418253.2_3'UTR	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	178						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGCTGCAAGGGGCCCCAGGGC	0.627000													26	73					0	0	1	0	0
IGFBP2	3485	broad.mit.edu	37	2	217525496	217525496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:217525496C>T	ENST00000233809.4	+	2	788	c.659C>T	c.(658-660)cCa>cTa	p.P220L	IGFBP2_ENST00000456764.1_Missense_Mutation_p.P76L	NM_000597.2	NP_000588.2	P18065	IBP2_HUMAN	insulin-like growth factor binding protein 2, 36kDa	220					positive regulation of activated T cell proliferation|regulation of cell growth|regulation of insulin-like growth factor receptor signaling pathway	extracellular space	insulin-like growth factor I binding|insulin-like growth factor II binding			endometrium(2)|large_intestine(1)|lung(2)	5		Renal(323;0.0458)		Epithelial(149;2.9e-06)|all cancers(144;0.000223)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00968)		AAGCTGCGACCACCCCCTGCC	0.627000													5	10					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41585335	41585335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41585335C>T	ENST00000402685.2	+	2	732	c.724C>T	c.(724-726)Cga>Tga	p.R242*		NM_001164595.1	NP_001158067.1	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	242	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TATAGGAGGTCGACCAAATCA	0.303000													14	34					0	0	1	0	0
HP	3240	broad.mit.edu	37	16	72094210	72094210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72094210G>A	ENST00000355906.5	+	7	700	c.642G>A	c.(640-642)gcG>gcA	p.A214A	HP_ENST00000565574.1_Silent_p.A155A|HP_ENST00000562526.1_Intron|HP_ENST00000398131.2_Silent_p.A155A|HP_ENST00000570083.1_Silent_p.A155A|HPR_ENST00000356967.5_Intron	NM_005143.3	NP_005134.1	P00738	HPT_HUMAN	haptoglobin	214	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|urinary_tract(1)	7		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		ATGCAACAGCGAAAGACATTG	0.453000													23	50					0	0	1	0	0
MAPK14	1432	broad.mit.edu	37	6	36040749	36040749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36040749C>T	ENST00000229795.3	+	4	852	c.405C>T	c.(403-405)ctC>ctT	p.L135L	MAPK14_ENST00000229794.4_Silent_p.L135L|MAPK14_ENST00000310795.4_Silent_p.L135L|MAPK14_ENST00000468133.1_Silent_p.L58L	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	135	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						ACCAAATTCTCCGAGGTCTAA	0.378000													15	40					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181480566	181480566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181480566G>A	ENST00000526775.1	+	3	597	c.432G>A	c.(430-432)gtG>gtA	p.V144V	CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000358338.5_Silent_p.V95V|CACNA1E_ENST00000367570.1_Silent_p.V144V|CACNA1E_ENST00000360108.3_Silent_p.V144V|CACNA1E_ENST00000367573.2_Silent_p.V144V|CACNA1E_ENST00000357570.5_Silent_p.V95V	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	144					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TCAAAATTGTGGCCCTGGGGT	0.488000													77	172					0	0	1	0	0
SLC16A13	201232	broad.mit.edu	37	17	6941598	6941598	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6941598C>T	ENST00000308027.6	+	3	779	c.471C>T	c.(469-471)ccC>ccT	p.P157P		NM_201566.2	NP_963860.1	Q7RTY0	MOT13_HUMAN	solute carrier family 16, member 13	157						integral to membrane|plasma membrane	symporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						CATTTGCCCCCTTTTTCCAGT	0.652000													30	30					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56108789	56108789	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:56108789G>A	ENST00000394555.2	-	5	1033	c.598C>T	c.(598-600)Cag>Tag	p.Q200*	EFEMP1_ENST00000394554.1_Nonsense_Mutation_p.Q200*|EFEMP1_ENST00000355426.3_Nonsense_Mutation_p.Q200*|EFEMP1_ENST00000424836.2_Nonsense_Mutation_p.Q142*	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	200	EGF-like 2; calcium-binding (Potential).				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGAGGGCACTGACATGCAAAG	0.517000													21	83					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39170381	39170381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39170381C>T	ENST00000301819.6	+	14	2055	c.1878C>T	c.(1876-1878)atC>atT	p.I626I	TTC21A_ENST00000431162.2_Silent_p.I625I|TTC21A_ENST00000440121.1_Silent_p.I577I	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	625							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GGGCATCCATCTTATTGGAAC	0.552000													31	68					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896999	175896999	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175896999G>A	ENST00000359240.3	+	5	993	c.323G>A	c.(322-324)gGg>gAg	p.G108E	ADAM29_ENST00000404450.4_Missense_Mutation_p.G108E|ADAM29_ENST00000445694.1_Missense_Mutation_p.G108E|ADAM29_ENST00000514159.1_Missense_Mutation_p.G108E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	108					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TATGTGGAAGGGGACCCAGAA	0.453000													12	61					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6711072	6711072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6711072C>T	ENST00000245907.6	-	12	1497	c.1405G>A	c.(1405-1407)Gag>Aag	p.E469K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	469			E -> D (in dbSNP:rs11569422).		complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TTGAGGGTCTCCCCGGGTCTG	0.602000													26	199					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159921563	159921563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159921563C>T	ENST00000368093.3	-	4	874	c.758G>A	c.(757-759)gGa>gAa	p.G253E	SLAMF9_ENST00000368092.3_Missense_Mutation_p.G162E|SLAMF9_ENST00000466773.1_5'UTR	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	253						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GACCCAGAGTCCCATGGCCAG	0.488000													48	102					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3520891	3520891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3520891C>T	ENST00000262919.5	+	3	585	c.517C>T	c.(517-519)Cgt>Tgt	p.R173C	ATRN_ENST00000446916.2_Missense_Mutation_p.R173C	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	173	CUB.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding	p.R173C(1)		breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						AATGAGACTTCGTTTCAATCA	0.308000													52	234					0	0	1	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153279643	153279643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153279643G>A	ENST00000290722.1	-	2	208	c.156C>T	c.(154-156)ctC>ctT	p.L52L		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	52					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCATCCCTGGGAGCTGGTCTG	0.632000													6	8					0	0	1	0	0
CEACAM3	1084	broad.mit.edu	37	19	42300634	42300634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42300634C>T	ENST00000357396.3	+	1	266	c.25C>T	c.(25-27)Cac>Tac	p.H9Y	CEACAM3_ENST00000595255.1_3'UTR|CEACAM3_ENST00000344550.4_Missense_Mutation_p.H9Y|CEACAM3_ENST00000221999.4_Missense_Mutation_p.H9Y	NM_001815.2	NP_001806.2	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 3	9						integral to membrane		p.H9Y(1)		endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(3)|skin(4)|stomach(1)	19						AGCCTCTCCCCACAGAGAATG	0.602000													25	43					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118314941	118314941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118314941C>T	ENST00000369221.2	+	8	761	c.733C>T	c.(733-735)Cca>Tca	p.P245S		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	245					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity	p.P245A(2)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AGATTTCTTTCCAAATGGAGG	0.388000													54	117					0	0	1	0	0
MICU3	286097	broad.mit.edu	37	8	16935338	16935338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16935338C>T	ENST00000318063.5	+	4	656	c.614C>T	c.(613-615)tCa>tTa	p.S205L		NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		TGGAAAGGCTCATCGAAGCTA	0.284000													17	45					0	0	1	0	0
IGHD	3495	broad.mit.edu	37	14	106311229	106311229	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106311229G>A	ENST00000390556.2	-	0	333																											TTGTGCAGTGGGCACTGAGGA	0.607000													5	12					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69881562	69881562	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:69881562C>T	ENST00000358913.5	+	2	855	c.367C>T	c.(367-369)Cga>Tga	p.R123*	MYPN_ENST00000354393.2_Intron|MYPN_ENST00000540630.1_Nonsense_Mutation_p.R123*|MYPN_ENST00000373675.3_Nonsense_Mutation_p.R123*	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	123	Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GGATAACCCTCGAAGTCCCAC	0.433000													6	67					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149493792	149493792	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149493792C>T	ENST00000378016.2	+	0	6788							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGGATGGCTCGGATGAGGAG	0.657000													3	17					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81372163	81372163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81372163G>A	ENST00000398636.3	+	4	406	c.268G>A	c.(268-270)Gag>Aag	p.E90K	SFTPA1_ENST00000372313.5_Missense_Mutation_p.E31K|SFTPA1_ENST00000419470.2_Missense_Mutation_p.E105K|SFTPA1_ENST00000428376.2_Missense_Mutation_p.E90K|SFTPA1_ENST00000372308.3_Missense_Mutation_p.E90K	NM_001164644.1|NM_001164646.1|NM_005411.4	NP_001158116.1|NP_001158118.1|NP_005402.3	Q8IWL2	SFTA1_HUMAN	surfactant protein A1	90	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			AGAGAAGGGGGAGCCTGGCGA	0.632000													11	182					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422620	26422620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26422620C>T	ENST00000335473.7	+	43	6930	c.6680C>T	c.(6679-6681)cCc>cTc	p.P2227L	MYO18B_ENST00000536101.1_Missense_Mutation_p.P2227L|MYO18B_ENST00000407587.2_Missense_Mutation_p.P2228L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2227						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCTTCCTCTCCCCTGGCTTCT	0.577000													12	45					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026326	79026326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79026326G>A	ENST00000446378.2	+	2	1769	c.1738G>A	c.(1738-1740)Gaa>Aaa	p.E580K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	580	Glu-rich.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTTGTCTGAGGAAGAAAGAGA	0.423000													112	310					0	0	1	0	0
SYN3	8224	broad.mit.edu	37	22	33260980	33260980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:33260980G>A	ENST00000358763.2	-	6	875	c.633C>T	c.(631-633)ctC>ctT	p.L211L	SYN3_ENST00000332840.5_Silent_p.L211L	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	211	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						AGATCTTAATGAGCTGAGAGA	0.453000													66	147					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151789722	151789722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151789722C>T	ENST00000356728.6	-	2	196	c.42G>A	c.(40-42)ggG>ggA	p.G14G	RORC_ENST00000318247.6_Silent_p.G35G|RORC_ENST00000392697.3_Silent_p.G89G	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	35	Modulating (Potential).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACGACTTGTCCCCACAGATTT	0.498000													20	65					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140907670	140907670	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140907670G>A	ENST00000371372.1	+	18	2395	c.2250G>A	c.(2248-2250)gcG>gcA	p.A750A	CACNA1B_ENST00000277551.2_Silent_p.A750A|CACNA1B_ENST00000371363.1_Silent_p.A750A|CACNA1B_ENST00000371355.4_Silent_p.A751A|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000277550.3_Silent_p.A41A|CACNA1B_ENST00000371357.1_Silent_p.A751A	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	750					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGTCTGCCGCGAACATCTCCA	0.592000													8	29					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22364370	22364370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22364370G>A	ENST00000397121.2	-	3	466	c.149C>T	c.(148-150)tCc>tTc	p.S50F		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAACTCTTGGGAAAAATGAGA	0.274000													13	23					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52619652	52619652	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52619652C>T	ENST00000282641.2	-	3	236	c.49G>A	c.(49-51)Gaa>Aaa	p.E17K	A1CF_ENST00000373993.1_Missense_Mutation_p.E17K|A1CF_ENST00000395489.2_5'UTR|A1CF_ENST00000373997.3_Missense_Mutation_p.E17K|A1CF_ENST00000374001.1_Missense_Mutation_p.E17K|A1CF_ENST00000395495.1_Missense_Mutation_p.E17K|A1CF_ENST00000373995.3_5'UTR	NM_138932.2	NP_620310.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	17					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						AGGGCTGCTTCCTTCTGAGTG	0.483000													36	54					0	0	1	0	0
DCAF16	54876	broad.mit.edu	37	4	17805519	17805519	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:17805519A>C	ENST00000382247.1	-	3	1306	c.246T>G	c.(244-246)gaT>gaG	p.D82E	DCAF16_ENST00000536863.1_Missense_Mutation_p.D82E	NM_017741.3	NP_060211.3	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	82						CUL4 RING ubiquitin ligase complex				cervix(1)|endometrium(1)|lung(2)|ovary(1)	5						GTGTGCTTGGATCCAACAGTT	0.438000													19	112					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110833706	110833706	+	Missense_Mutation	SNP	G	G	A	rs150129180	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110833706G>A	ENST00000375820.4	-	29	2247	c.2126C>T	c.(2125-2127)cCa>cTa	p.P709L		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	709	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGTCCCCGGTGGCCCCATGTC	0.507000													11	22					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41419023	41419023	+	Silent	SNP	G	G	A	rs145714777		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41419023G>A	ENST00000551295.2	+	21	2712	c.2595G>A	c.(2593-2595)tcG>tcA	p.S865S	CNTN1_ENST00000347616.1_Silent_p.S865S|CNTN1_ENST00000348761.2_Silent_p.S854S|CNTN1_ENST00000550305.1_3'UTR	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	865	Fibronectin type-III 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AAGAGTACTCGGCCAGGCTCG	0.483000													64	205					0	0	1	0	0
NANOG	79923	broad.mit.edu	37	12	7945794	7945794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7945794C>T	ENST00000229307.4	+	2	619	c.400C>T	c.(400-402)Ctc>Ttc	p.L134F	NANOG_ENST00000526286.1_Missense_Mutation_p.L134F	NM_024865.2	NP_079141.2	Q9H9S0	NANOG_HUMAN	Nanog homeobox	134					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14				Kidney(36;0.0872)		CATCCTGAACCTCAGCTACAA	0.438000													4	42					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139756733	139756733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139756733C>T	ENST00000263549.3	-	3	1556	c.683G>A	c.(682-684)aGa>aAa	p.R228K		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	228						nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					ATGTGCATTTCTATAAATGGT	0.473000													33	126					0	0	1	0	0
NPIPB6	728741	broad.mit.edu	37	16	28354373	28354373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28354373G>A	ENST00000532254.1	-	7	1518	c.833C>T	c.(832-834)tCc>tTc	p.S278F	NPIPB6_ENST00000533640.1_Missense_Mutation_p.S260F					nuclear pore complex interacting protein family, member B6																		GAGGCTCAGGGAGTTATCAGT	0.507000													24	75					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2972186	2972186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2972186C>T	ENST00000396946.4	-	11	1956	c.1553G>A	c.(1552-1554)cGa>cAa	p.R518Q		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	518					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		ATCTGATGTTCGCTTCAGGCT	0.493000			Mis		DLBCL								7	25					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160784397	160784397	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160784397G>A	ENST00000263285.5	+	4	948	c.918G>A	c.(916-918)agG>agA	p.R306R	LY9_ENST00000471816.1_3'UTR|LY9_ENST00000341032.4_Silent_p.R306R|LY9_ENST00000368035.1_5'UTR|LY9_ENST00000368040.1_5'UTR|LY9_ENST00000368041.2_Silent_p.R266R	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	306	Ig-like V-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTAAATCCAGGGATCCTTACA	0.532000													6	54					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197404228	197404228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197404228G>A	ENST00000367397.1	+	5	2236	c.1378G>A	c.(1378-1380)Gat>Aat	p.D460N	CRB1_ENST00000535699.1_Missense_Mutation_p.D1055N|CRB1_ENST00000367400.3_Missense_Mutation_p.D1079N|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000544212.1_Missense_Mutation_p.D560N|CRB1_ENST00000367399.2_Missense_Mutation_p.D967N			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1079	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GGATAATACAGATATTTATGT	0.418000													19	109					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152081480	152081480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152081480C>T	ENST00000368804.1	-	2	4212	c.4213G>A	c.(4213-4215)Gag>Aag	p.E1405K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1405	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGTTGCTCGCGCTCCTGG	0.577000													46	135					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322632	55322632	+	Missense_Mutation	SNP	G	G	A	rs72140406		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55322632G>A	ENST00000314644.2	+	1	850	c.850G>A	c.(850-852)Gaa>Aaa	p.E284K		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						ACACAGTTCTGAAGGGCGCTG	0.453000										HNSCC(20;0.049)			29	139					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19319266	19319266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:19319266C>T	ENST00000461366.1	+	14	1889	c.1674C>T	c.(1672-1674)ctC>ctT	p.L558L		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	558							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						GGGCCGGGCTCATGGGCCTGG	0.687000													8	4					0	0	1	0	0
HTRA1	5654	broad.mit.edu	37	10	124266334	124266334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124266334G>A	ENST00000368984.3	+	4	1033	c.905G>A	c.(904-906)cGa>cAa	p.R302Q		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	302	Serine protease.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				ACCACCCAGCGAGGCGGCAAA	0.622000													27	72					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401599	89401599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89401599C>T	ENST00000439576.2	+	12	6157	c.5783C>T	c.(5782-5784)cCa>cTa	p.P1928L	ACAN_ENST00000559004.1_Missense_Mutation_p.P1928L|ACAN_ENST00000561243.1_Missense_Mutation_p.P1928L|ACAN_ENST00000352105.7_Missense_Mutation_p.P1928L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1928					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTGGAACTCCATCTAGTTTC	0.537000													25	75					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158226033	158226033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158226033G>A	ENST00000289429.5	+	3	1098	c.565G>A	c.(565-567)Ggt>Agt	p.G189S		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	189	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TTTCATCTTGGGTCTTCTTGA	0.458000													17	85					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107692680	107692680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107692680C>T	ENST00000388781.3	-	26	3861	c.3778G>A	c.(3778-3780)Gaa>Aaa	p.E1260K	LAMB4_ENST00000205386.4_Missense_Mutation_p.E1260K|LAMB4_ENST00000388780.3_Missense_Mutation_p.E1260K	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1260	Domain II.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TTCAGTTGTTCATTTAGCTGC	0.323000													14	95					0	0	1	0	0
ELOVL7	79993	broad.mit.edu	37	5	60067864	60067864	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:60067864G>A	ENST00000505959.1	-	6	608	c.82C>T	c.(82-84)Cta>Tta	p.L28L	ELOVL7_ENST00000508821.1_Silent_p.L41L|ELOVL7_ENST00000425382.1_Silent_p.L41L|ELOVL7_ENST00000438340.1_Silent_p.L41L			A1L3X0	ELOV7_HUMAN	ELOVL fatty acid elongase 7	41					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	9		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				TAGAATCCTAGGAGGATGGTT	0.423000													13	17					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199219	4199219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:4199219G>A	ENST00000296358.4	-	5	1366	c.1342C>T	c.(1342-1344)Cac>Tac	p.H448Y		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	448					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGCTCTCGGTGAATGGATTCA	0.547000													22	96					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228526038	228526038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228526038G>A	ENST00000570156.2	+	79	19994	c.19920G>A	c.(19918-19920)gaG>gaA	p.E6640E	OBSCN_ENST00000366707.4_Silent_p.E3317E|OBSCN_ENST00000422127.1_Silent_p.E5683E|OBSCN_ENST00000284548.11_Silent_p.E5683E|OBSCN_ENST00000366709.4_Silent_p.E2802E	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5683	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCCTGGGGAGGCTGTGTCTG	0.632000													6	8					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577519	9577519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9577519G>A	ENST00000301480.4	-	10	2317	c.2104C>T	c.(2104-2106)Cgc>Tgc	p.R702C		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	702					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						GTTTTTAAGCGATCATGAAAG	0.378000													60	195					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70236545	70236545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:70236545C>T	ENST00000342771.4	+	11	2066	c.1745C>T	c.(1744-1746)tCc>tTc	p.S582F	AUTS2_ENST00000406775.2_Missense_Mutation_p.S582F	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	582										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CTCTTCCATTCCTATCCTCCT	0.493000													38	79					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101016248	101016248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101016248G>A	ENST00000360863.6	-	17	2727	c.2533C>T	c.(2533-2535)Cct>Tct	p.P845S	RGS22_ENST00000519421.1_5'UTR|RGS22_ENST00000523437.1_Missense_Mutation_p.P833S|RGS22_ENST00000523287.1_Missense_Mutation_p.P664S	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	845					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TATTCTGCAGGAACATTATCC	0.373000													22	60					0	0	1	0	0
PER2	8864	broad.mit.edu	37	2	239161976	239161976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239161976G>A	ENST00000254657.3	-	19	2967	c.2688C>T	c.(2686-2688)ttC>ttT	p.F896F	AC096574.4_ENST00000456601.1_RNA|PER2_ENST00000254658.3_3'UTR	NM_022817.2	NP_073728.1	O15055	PER2_HUMAN	period circadian clock 2	896	Pro-rich.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		AAGGGGCAGGGAAAGGTGGGG	0.652000													22	37					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77945045	77945045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77945045C>T	ENST00000493585.1	-	4	663	c.641G>A	c.(640-642)aGa>aAa	p.R214K	ISM2_ENST00000429906.1_Silent_p.Q248Q|ISM2_ENST00000393684.3_Silent_p.Q241Q|ISM2_ENST00000412904.1_Silent_p.Q248Q|ISM2_ENST00000342219.4_Silent_p.Q329Q	NM_182509.3	NP_872315.2	Q6H9L7	ISM2_HUMAN	isthmin 2	0						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						TCCACTCCTTCTGAGGCTCAT	0.582000													24	47					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56136651	56136651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56136651G>A	ENST00000319441.4	+	2	348	c.184G>A	c.(184-186)Gaa>Aaa	p.E62K	PCK1_ENST00000535860.1_5'UTR|PCK1_ENST00000543666.1_5'UTR	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	62					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCAGATGGAGGAAGAGGGCAT	0.607000													41	81					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193361862	193361862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:193361862C>T	ENST00000361510.2	+	16	1810	c.1576C>T	c.(1576-1578)Ctg>Ttg	p.L526L	OPA1_ENST00000361908.3_Silent_p.L508L|OPA1_ENST00000361150.2_Silent_p.L472L|OPA1_ENST00000392438.3_Silent_p.L471L|OPA1_ENST00000361715.2_Silent_p.L490L|OPA1_ENST00000361828.2_Silent_p.L489L	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	471					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		CAAAGTAGACCTGGCAGAGAA	0.433000													32	44					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55138596	55138596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55138596C>T	ENST00000257290.5	+	9	1604	c.1273C>T	c.(1273-1275)Cat>Tat	p.H425Y	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	425	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CGATGATCACCATGGCTCAAC	0.468000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			28	94					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227886797	227886797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227886797C>T	ENST00000396625.3	-	44	4390	c.4183G>A	c.(4183-4185)Ggg>Agg	p.G1395R	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1392R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1395	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCAGGGAGCCCCATGGCTCCT	0.522000													56	174					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50208317	50208317	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50208317C>T	ENST00000392518.4	+	9	1197	c.825C>T	c.(823-825)gcC>gcT	p.A275A	CPT1C_ENST00000323446.5_Silent_p.A275A|CPT1C_ENST00000598293.1_Silent_p.A275A|CPT1C_ENST00000354199.5_Silent_p.A275A|CPT1C_ENST00000405931.2_Silent_p.A264A	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	275					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CTGGGAATGCCGTCCATGCCC	0.647000													34	63					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791659	95791659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95791659G>A	ENST00000260766.3	+	2	1490	c.856G>A	c.(856-858)Gac>Aac	p.D286N	PLCE1_ENST00000371380.2_Missense_Mutation_p.D286N	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	286					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TTGTAGGAAAGACTTTACTGA	0.378000													32	128					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39377166	39377166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39377166G>A	ENST00000545653.1	-	11	2190	c.1660C>T	c.(1660-1662)Cct>Tct	p.P554S	DAB2_ENST00000509337.1_Missense_Mutation_p.P554S|DAB2_ENST00000320816.6_Missense_Mutation_p.P575S|DAB2_ENST00000339788.6_Missense_Mutation_p.P357S	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	575					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GATGCAGAAGGGCCCCAGACA	0.532000											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	59					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82402423	82402423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:82402423G>A	ENST00000370728.1	+	7	944	c.299G>A	c.(298-300)cGa>cAa	p.R100Q	LPHN2_ENST00000359929.3_Missense_Mutation_p.R100Q|LPHN2_ENST00000394879.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370730.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000271029.4_Missense_Mutation_p.R100Q|LPHN2_ENST00000370715.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000335786.5_Missense_Mutation_p.R100Q|LPHN2_ENST00000370725.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370723.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370721.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000370713.1_Missense_Mutation_p.R100Q|LPHN2_ENST00000319517.6_Missense_Mutation_p.R100Q|LPHN2_ENST00000370717.2_Missense_Mutation_p.R100Q|LPHN2_ENST00000370727.1_Missense_Mutation_p.R100Q			O95490	LPHN2_HUMAN	latrophilin 2	100	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TGCAACAATCGAACACAGTGT	0.318000													39	87					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111854894	111854894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111854894C>T	ENST00000369740.1	+	4	241	c.138C>T	c.(136-138)atC>atT	p.I46I	CHIA_ENST00000353665.6_Intron|CHIA_ENST00000343320.6_Silent_p.I46I|CHIA_ENST00000483391.1_Intron|CHIA_ENST00000451398.2_Intron|CHIA_ENST00000430615.1_Intron	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	46					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		CTGACAACATCGACCCCTGCC	0.567000													39	88					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10079019	10079019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:10079019G>A	ENST00000382452.2	-	14	1905	c.1623C>T	c.(1621-1623)tcC>tcT	p.S541S	WDR1_ENST00000499869.2_Silent_p.S541S|WDR1_ENST00000502702.1_Silent_p.S401S|WDR1_ENST00000382451.2_Silent_p.S401S|WDR1_ENST00000515743.1_5'UTR	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	541					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CATTGTCTGGGGACCAGGCCA	0.507000													22	88					0	0	1	0	0
AP5B1	91056	broad.mit.edu	37	11	65545600	65545600	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65545600G>A	ENST00000532090.2	-	2	2574	c.2364C>T	c.(2362-2364)tcC>tcT	p.S788S		NM_138368.4	NP_612377.4	Q2VPB7	YK046_HUMAN	adaptor-related protein complex 5, beta 1 subunit	731							protein binding			lung(1)	1						CTGGCAGGCAGGAATCCCAGA	0.632000													38	88					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39495058	39495058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39495058G>A	ENST00000265707.5	+	9	708	c.663G>A	c.(661-663)atG>atA	p.M221I	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.M197I	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	221	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			ATTTTTAGATGTTTACCCAGT	0.289000													10	35					0	0	1	0	0
FANCG	2189	broad.mit.edu	37	9	35079515	35079515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35079515G>A	ENST00000378643.3	-	1	498	c.7C>T	c.(7-9)Cgc>Tgc	p.R3C		NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	3					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTGGTCTGGCGGGACATGGTG	0.662000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					19	101					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17522690	17522690	+	Missense_Mutation	SNP	G	G	A	rs140313023		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17522690G>A	ENST00000005226.7	-	23	2287	c.2288C>T	c.(2287-2289)tCc>tTc	p.S763F	USH1C_ENST00000527720.1_Missense_Mutation_p.S432F|USH1C_ENST00000529563.1_5'UTR|USH1C_ENST00000527020.1_Missense_Mutation_p.S444F|USH1C_ENST00000318024.4_Missense_Mutation_p.S463F	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	463					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						CAGGTCTAAGGATCCCTCCTG	0.592000													8	15					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846378	47846378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47846378G>A	ENST00000339488.4	-	3	2235	c.2202C>T	c.(2200-2202)ttC>ttT	p.F734F		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	734						integral to membrane	hedgehog receptor activity										ATACAAATGTGAAAAGCAGTG	0.403000													9	21					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332827	100332827	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:100332827G>A	ENST00000341853.1	-	0	1364					NR_003260.1																						TGACTACAACGAGGGACACAG	0.612000													14	112					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430821	43430821	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43430821C>T	ENST00000446844.3	-	0	846				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCCTTATTCTCCCTGGGGTTT	0.488000													73	366					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303874	151303874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151303874C>T	ENST00000370323.4	-	4	535	c.219G>A	c.(217-219)gaG>gaA	p.E73E	MAGEA10_ENST00000244096.3_Silent_p.E73E|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	73								p.E73D(1)		endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCAGAAACCTCCTCTGGGG	0.532000													55	47					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18181530	18181530	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18181530G>A	ENST00000321105.5	-	18	2500	c.2286C>T	c.(2284-2286)ccC>ccT	p.P762P	TOP3A_ENST00000542570.1_Silent_p.P667P|TOP3A_ENST00000540524.1_Silent_p.P292P	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	762					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						GGCGGCCAGAGGGCTGGCTAG	0.627000													31	49					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471878	47471878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:47471878C>T	ENST00000266581.4	-	2	1374	c.908G>A	c.(907-909)gGg>gAg	p.G303E	AMIGO2_ENST00000429635.1_Missense_Mutation_p.G303E|AMIGO2_ENST00000321382.3_Missense_Mutation_p.G303E|AMIGO2_ENST00000550413.1_Missense_Mutation_p.G303E	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	303	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane		p.G303V(1)		endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CAGTCTTTCCCCGACCTGAGC	0.483000													18	153					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679051	100679051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100679051G>A	ENST00000306151.4	+	3	4418	c.4354G>A	c.(4354-4356)Gaa>Aaa	p.E1452K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1452	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAAGGAAAGAC	0.493000													98	454					0	0	1	0	0
ITPA	3704	broad.mit.edu	37	20	3202495	3202495	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3202495C>T	ENST00000380113.3	+	7	612	c.420C>T	c.(418-420)atC>atT	p.I140I	ITPA_ENST00000483354.1_3'UTR|ITPA_ENST00000399838.3_Silent_p.I99I|ITPA_ENST00000455664.1_Silent_p.I123I	NM_033453.3	NP_258412.1	Q9BY32	ITPA_HUMAN	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	140					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			autonomic_ganglia(1)|large_intestine(3)|ovary(1)|stomach(1)	6						AGGGCCGGATCGTGGCACCCA	0.592000													16	23					0	0	1	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140782717	140782717	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140782717C>T	ENST00000573521.1	+	1	198	c.198C>T	c.(196-198)atC>atT	p.I66I	PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGTCCGCATCGTCTCTAGAG	0.612000													40	86					0	0	1	0	0
MLC1	23209	broad.mit.edu	37	22	50521574	50521574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50521574G>A	ENST00000311597.5	-	3	812	c.206C>T	c.(205-207)tCg>tTg	p.S69L	MLC1_ENST00000450140.2_Missense_Mutation_p.S69L|MLC1_ENST00000538737.1_Missense_Mutation_p.S69L|MLC1_ENST00000535444.1_5'UTR|MLC1_ENST00000395876.2_Missense_Mutation_p.S69L|MLC1_ENST00000431262.2_Intron	NM_015166.3	NP_055981.1	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with subcortical cysts 1	69						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(3)	18		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		CAGGTACAGCGAAAACCCCGA	0.607000													26	72					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530577	140530577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140530577G>A	ENST00000231136.1	+	1	739	c.739G>A	c.(739-741)Gaa>Aaa	p.E247K	PCDHB6_ENST00000543635.1_Missense_Mutation_p.E111K	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		247	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGCTCTATGAAGCACAAGT	0.547000													19	39					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953629	140953629	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140953629C>T	ENST00000277549.5	+	31	4729	c.2160C>T	c.(2158-2160)gcC>gcT	p.A720A	CACNA1B_ENST00000277551.2_Silent_p.A1524A|CACNA1B_ENST00000371372.1_Silent_p.A1524A|CACNA1B_ENST00000371363.1_Silent_p.A1524A|CACNA1B_ENST00000371355.4_Silent_p.A1525A|CACNA1B_ENST00000371357.1_Silent_p.A1525A			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1524					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	AGATCATCGCCTTTGGGGTGC	0.498000													4	11					0	0	1	0	0
PTGES	9536	broad.mit.edu	37	9	132510954	132510954	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:132510954G>A	ENST00000340607.4	-	2	223	c.189C>T	c.(187-189)ccC>ccT	p.P63P	PTGES_ENST00000481476.1_5'UTR	NM_004878.4	NP_004869.1	O14684	PTGES_HUMAN	prostaglandin E synthase	63					prostaglandin biosynthetic process|signal transduction	integral to membrane|membrane fraction	glutathione binding|prostaglandin-E synthase activity			lung(1)|skin(1)	2		Ovarian(14;0.00556)				GTTCCACGTCGGGGTCGCTCC	0.602000													5	20					0	0	1	0	0
CAPN3	825	broad.mit.edu	37	15	42689053	42689053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42689053G>A	ENST00000397163.3	+	9	1390	c.1171G>A	c.(1171-1173)Gtc>Atc	p.V391I	CAPN3_ENST00000349748.3_Missense_Mutation_p.V343I|CAPN3_ENST00000318023.7_Missense_Mutation_p.V391I|CAPN3_ENST00000356316.3_Missense_Mutation_p.V304I|RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000357568.3_Missense_Mutation_p.V391I	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	391	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		GCAGCACCAGGTCACTGAGGA	0.542000													5	78					0	0	1	0	0
SLC39A13	91252	broad.mit.edu	37	11	47436453	47436453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47436453G>A	ENST00000362021.4	+	8	954	c.912G>A	c.(910-912)aaG>aaA	p.K304K	SLC39A13_ENST00000524928.1_3'UTR|SLC39A13_ENST00000533076.1_Silent_p.K304K|SLC39A13_ENST00000354884.4_Silent_p.K304K	NM_001128225.2	NP_001121697.1	Q96H72	S39AD_HUMAN	solute carrier family 39 (zinc transporter), member 13	304					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|kidney(1)|lung(1)|prostate(1)	4				Lung(87;0.0936)		AGTCCCCCAAGGGAGTAGGTA	0.682000													23	56					0	0	1	0	0
DEFA4	1669	broad.mit.edu	37	8	6794376	6794376	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:6794376G>T	ENST00000297435.2	-	2	170	c.46C>A	c.(46-48)Cag>Aag	p.Q16K		NM_001925.1	NP_001916.1	P12838	DEF4_HUMAN	defensin, alpha 4, corticostatin	16					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	10				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		GCCCGGACCTGGAGGGCTACC	0.607000													7	44					8.12818e-05	8.14103e-05	1	1	0
PON1	5444	broad.mit.edu	37	7	94935616	94935616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94935616C>T	ENST00000222381.3	-	7	992	c.761G>A	c.(760-762)tGg>tAg	p.W254*	PON1_ENST00000542556.1_Nonsense_Mutation_p.W254*	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	254					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AGTTAAAGTCCAATTAGCATG	0.328000													36	170					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795593	142795593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142795593C>T	ENST00000370498.1	-	2	838	c.85G>A	c.(85-87)Gag>Aag	p.E29K		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	29										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TTCGGTGCCTCCTGCATCTGA	0.423000													21	20					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202461	140202461	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140202461C>T	ENST00000529859.1	+	1	1101	c.1101C>T	c.(1099-1101)gtC>gtT	p.V367V	PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000378126.3_Silent_p.V367V|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Silent_p.V367V	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCACGGTCATTGCTCTGA	0.537000													53	93					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29886201	29886201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29886201G>A	ENST00000310624.6	+	4	2605	c.2572G>A	c.(2572-2574)Gac>Aac	p.D858N		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	864	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						GGAGAAGAAGGACAGCAAGAA	0.527000													8	23					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236949460	236949460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:236949460C>T	ENST00000409538.1	+	14	2998	c.2502C>T	c.(2500-2502)tcC>tcT	p.S834S	AGAP1_ENST00000428334.2_Silent_p.S461S|AGAP1_ENST00000336665.5_Silent_p.S569S|AGAP1_ENST00000304032.7_Silent_p.S622S			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	622					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GCGGGAACTCCCACTGTGTGG	0.627000													24	56					0	0	1	0	0
TCF7L2	6934	broad.mit.edu	37	10	114903687	114903687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:114903687C>T	ENST00000355995.4	+	7	1198	c.691C>T	c.(691-693)Cca>Tca	p.P231S	TCF7L2_ENST00000542695.1_5'UTR|TCF7L2_ENST00000349937.2_Missense_Mutation_p.P231S|TCF7L2_ENST00000352065.5_Missense_Mutation_p.P208S|TCF7L2_ENST00000369389.1_5'UTR|TCF7L2_ENST00000543371.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000538897.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000536810.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000369397.4_Missense_Mutation_p.P208S|TCF7L2_ENST00000534894.1_Missense_Mutation_p.P231S|TCF7L2_ENST00000355717.4_Missense_Mutation_p.P255S|TCF7L2_ENST00000369395.1_Missense_Mutation_p.P256S|TCF7L2_ENST00000545257.1_Missense_Mutation_p.P231S			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	231	Mediates interaction with MAD2L2.|Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		CTCAGGAATCCCACGGCCTCC	0.527000			T	VTI1A	colorectal								13	41					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163393520	163393520	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163393520G>A	ENST00000332142.5	-	3	477	c.378C>T	c.(376-378)atC>atT	p.I126I	KCNH7_ENST00000328032.4_Silent_p.I126I	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	126	PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CAAAATTAATGATGAACATCA	0.363000													61	139					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27350447	27350447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:27350447G>A	ENST00000429845.2	-	11	1048	c.686C>T	c.(685-687)tCc>tTc	p.S229F	NEK10_ENST00000341435.5_Missense_Mutation_p.S229F			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	229							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AGCCAGAAGGGAACCCAATAG	0.333000													8	22					0	0	1	0	0
OR4C11	219429	broad.mit.edu	37	11	55371088	55371088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55371088G>A	ENST00000302231.4	-	1	786	c.762C>T	c.(760-762)ttC>ttT	p.F254F		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	254					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						GTGTATATATGAATATACATG	0.438000													8	83					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27781201	27781201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27781201C>T	ENST00000261588.4	+	21	4014	c.3995C>T	c.(3994-3996)tCc>tTc	p.S1332F		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1332										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GTCCACGTCTCCCTGGATGGC	0.567000													68	136					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50158630	50158630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50158630C>T	ENST00000284509.6	-	26	3220	c.3079G>A	c.(3079-3081)Ggg>Agg	p.G1027R	ATP8B4_ENST00000559829.1_Missense_Mutation_p.G1027R	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1027					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GCAATGCTCCCCCAGATGAAG	0.383000													31	89					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9084263	9084263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9084263C>T	ENST00000397910.4	-	1	7755	c.7552G>A	c.(7552-7554)Ggc>Agc	p.G2518S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2518	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGAGAAAGCCCATGGCAGGT	0.512000													13	33					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169340494	169340494	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169340494G>A	ENST00000511577.1	-	19	2816	c.2569C>T	c.(2569-2571)Caa>Taa	p.Q857*	DDX60L_ENST00000505890.1_Nonsense_Mutation_p.Q857*|DDX60L_ENST00000260184.7_Nonsense_Mutation_p.Q857*			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	857	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		ACCCATTTTTGGCGATGAGGA	0.368000													5	8					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9028347	9028347	+	Missense_Mutation	SNP	G	G	A	rs150243586	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9028347G>A	ENST00000397910.4	-	11	36648	c.36445C>T	c.(36445-36447)Cgc>Tgc	p.R12149C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12151	SEA 1.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGTCAGGGCGATGTGTGCAG	0.557000													48	120					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50103168	50103168	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50103168C>T	ENST00000418929.2	+	5	4330	c.4318C>T	c.(4318-4320)Ccc>Tcc	p.P1440S		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	619							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		TCCGGGGCTCCCCAGTGCCAA	0.612000													7	33					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124856640	124856640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124856640G>A	ENST00000356219.3	-	21	2890	c.2735C>T	c.(2734-2736)cCc>cTc	p.P912L	NCOR2_ENST00000404121.2_Missense_Mutation_p.P465L|NCOR2_ENST00000405201.1_Missense_Mutation_p.P912L|NCOR2_ENST00000404621.1_Missense_Mutation_p.P894L|NCOR2_ENST00000429285.2_Missense_Mutation_p.P894L|NCOR2_ENST00000397355.1_Missense_Mutation_p.P895L	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	912					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCTGTCCTGGGGGGCGCCCGA	0.706000													20	66					0	0	1	0	0
MEX3B	84206	broad.mit.edu	37	15	82335978	82335978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:82335978G>A	ENST00000329713.4	-	2	1668	c.1233C>T	c.(1231-1233)ttC>ttT	p.F411F	MEX3B_ENST00000558133.1_3'UTR	NM_032246.3	NP_115622.2	Q6ZN04	MEX3B_HUMAN	mex-3 RNA binding family member B	411					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)	19						CACCCCCGGGGAAGACCACGg	0.672000													10	23					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11504573	11504573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11504573G>A	ENST00000379237.1	-	15	2748	c.2354C>T	c.(2353-2355)cCc>cTc	p.P785L	USP6NL_ENST00000277575.5_Missense_Mutation_p.P802L	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	785						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						ATATCTCACGGGACTATCTAC	0.537000													56	164					0	0	1	0	0
ANAPC1	64682	broad.mit.edu	37	2	112529932	112529932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:112529932G>A	ENST00000341068.3	-	47	6477	c.5705C>T	c.(5704-5706)cCt>cTt	p.P1902L		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1902					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						TAGTCCTATAGGTGGCAGGTG	0.502000													4	32					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84564673	84564673	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84564673G>A	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							TTGTCGGCCAGAATTATCCTG	0.478000													6	26					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49831842	49831842	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49831842C>T	ENST00000527477.1	+	0	2067																											ACCCCTTTATCCCATAAAGCC	0.388000													60	94					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137928403	137928403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:137928403C>T	ENST00000409968.1	+	7	1796	c.1618C>T	c.(1618-1620)Cca>Tca	p.P540S	THSD7B_ENST00000272643.3_Missense_Mutation_p.P540S|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.P509S					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTGTGAGGATCCAATGTGCTA	0.512000													18	48					0	0	1	0	0
HIBADH	11112	broad.mit.edu	37	7	27689131	27689131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27689131G>A	ENST00000265395.2	-	2	419	c.213C>T	c.(211-213)ttC>ttT	p.F71F		NM_152740.3	NP_689953.1	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase	71					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(4)|kidney(2)|lung(3)|ovary(2)|prostate(1)	12			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	AGGCATCAGGGAACACATCAT	0.363000													22	43					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074991	9074991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9074991G>A	ENST00000397910.4	-	3	12658	c.12455C>T	c.(12454-12456)tCt>tTt	p.S4152F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4154	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCTTCCACAGAGGGAGGGCT	0.498000													8	100					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61865750	61865750	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61865750G>A	ENST00000280772.1	-	28	3432	c.3241C>T	c.(3241-3243)Cga>Tga	p.R1081*	ANK3_ENST00000503366.1_Nonsense_Mutation_p.R1082*|ANK3_ENST00000373827.2_Nonsense_Mutation_p.R1075*|ANK3_ENST00000355288.2_Nonsense_Mutation_p.R215*	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1081	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTTTCACTTCGAAGAACAATG	0.383000													14	62					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204981969	204981969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204981969G>A	ENST00000367172.4	+	31	4115	c.3787G>A	c.(3787-3789)Gaa>Aaa	p.E1263K	NFASC_ENST00000404076.1_Missense_Mutation_p.E1073K|NFASC_ENST00000513543.1_Missense_Mutation_p.E1085K|NFASC_ENST00000367171.4_Missense_Mutation_p.E1248K|NFASC_ENST00000339876.6_Missense_Mutation_p.E1156K|NFASC_ENST00000539706.1_Missense_Mutation_p.E1090K|NFASC_ENST00000404907.1_Missense_Mutation_p.E1090K|NFASC_ENST00000360049.4_Missense_Mutation_p.E1085K|NFASC_ENST00000367170.4_Missense_Mutation_p.E1184K|NFASC_ENST00000401399.1_Missense_Mutation_p.E1156K|NFASC_ENST00000367169.4_Missense_Mutation_p.E987K|NFASC_ENST00000338586.6_Missense_Mutation_p.E1140K|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000338515.6_Missense_Mutation_p.E1173K			O94856	NFASC_HUMAN	neurofascin	1263					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGACCCCAAGGAAGAGGATGG	0.542000													33	93					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68617472	68617472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68617472G>A	ENST00000423218.2	-	18	2414	c.2319C>T	c.(2317-2319)gtC>gtT	p.V773V	ITGA11_ENST00000315757.7_Silent_p.V773V			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	773					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GATGTACCGAGACTCTGAGAG	0.622000													40	57					0	0	1	0	0
SET	6418	broad.mit.edu	37	9	131456259	131456259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131456259G>A	ENST00000322030.8	+	7	1105	c.748G>A	c.(748-750)Gaa>Aaa	p.E250K	SET_ENST00000372692.4_Missense_Mutation_p.E263K|SET_ENST00000477806.1_3'UTR|SET_ENST00000372688.4_Missense_Mutation_p.E239K|SET_ENST00000409104.3_Missense_Mutation_p.E241K	NM_003011.3	NP_003002.2	Q01105	SET_HUMAN	SET nuclear oncogene	263	Asp/Glu-rich (highly acidic).				DNA replication|mRNA metabolic process|negative regulation of histone acetylation|negative regulation of neuron apoptosis|negative regulation of transcription, DNA-dependent|nucleocytoplasmic transport|nucleosome assembly|nucleosome disassembly	cytosol|endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm|protein complex	histone binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity			endometrium(2)|kidney(1)|lung(2)	5		Myeloproliferative disorder(178;0.204)		GBM - Glioblastoma multiforme(294;3.1e-09)		agatattgacgaagaagggga	0.383000			T	NUP214	AML								8	21					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913356	77913356	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:77913356G>A	ENST00000321110.1	-	2	857	c.562C>T	c.(562-564)Ccc>Tcc	p.P188S		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	188	Pro-rich.						nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						GGCTCCTGGGGAGGTGGAAGC	0.542000													21	18					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66648120	66648120	+	Missense_Mutation	SNP	G	G	A	rs147474467		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:66648120G>A	ENST00000359626.5	+	14	1870	c.1706G>A	c.(1705-1707)cGa>cAa	p.R569Q		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	569					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				TAGCAACAACGAACTGTCTAC	0.498000													8	18					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090556	9090556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9090556G>A	ENST00000397910.4	-	1	1462	c.1259C>T	c.(1258-1260)aCc>aTc	p.T420I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	420	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAGTGATGGGTGTTGGTCTC	0.502000													21	56					0	0	1	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27911626	27911626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27911626C>T	ENST00000326019.6	+	12	2545	c.2263C>T	c.(2263-2265)Cca>Tca	p.P755S		NM_018158.2	NP_060628.2	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger), member 1, adaptor protein	755						cytoplasm|nucleus	double-stranded RNA binding|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.155)					AACACCTGGTCCAGGCAAAGT	0.353000													11	49					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086447	92086447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92086447C>T	ENST00000298047.6	+	1	1186	c.1169C>T	c.(1168-1170)cCt>cTt	p.P390L	FAT3_ENST00000541502.1_Missense_Mutation_p.P390L|FAT3_ENST00000409404.2_Missense_Mutation_p.P390L|FAT3_ENST00000525166.1_Missense_Mutation_p.P240L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	390	Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAATTTTCCCCTCCTGGTGTC	0.398000										TCGA Ovarian(4;0.039)			11	19					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74447035	74447035	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:74447035C>T	ENST00000339953.5	-	5	697	c.576G>A	c.(574-576)ggG>ggA	p.G192G		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	192						extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						TGATTGTCTTCCCGTTGACCT	0.627000													9	174					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76063292	76063292	+	Missense_Mutation	SNP	C	C	T	rs149762228		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76063292C>T	ENST00000393004.2	-	4	813	c.592G>A	c.(592-594)Gac>Aac	p.D198N	FILIP1_ENST00000237172.7_Missense_Mutation_p.D198N|FILIP1_ENST00000370020.1_Missense_Mutation_p.D99N			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	198										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GTGAAGTCGTCGCTCTTGTTC	0.532000													13	162					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113283333	113283333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113283333C>T	ENST00000362072.3	-	7	1427	c.1083G>A	c.(1081-1083)agG>agA	p.R361R	DRD2_ENST00000544518.1_Silent_p.R360R|DRD2_ENST00000542968.1_Silent_p.R361R|DRD2_ENST00000346454.3_Silent_p.R332R|DRD2_ENST00000538967.1_Silent_p.R363R|DRD2_ENST00000355319.2_Silent_p.R363R	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	361	Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGGAGAGCTTCCTACGGCTCA	0.567000													25	56					0	0	1	0	0
AVPR1B	553	broad.mit.edu	37	1	206224750	206224750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206224750G>A	ENST00000367126.4	+	1	775	c.310G>A	c.(310-312)Gac>Aac	p.D104N		NM_000707.3	NP_000698.1	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	104					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)|skin(2)	20			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCAGGGCCCCGACCTCCTGTG	0.632000													21	53					0	0	1	0	0
SNRPB	6628	broad.mit.edu	37	20	2442431	2442431	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2442431G>T	ENST00000438552.2	-	7	856	c.694C>A	c.(694-696)Ccc>Acc	p.P232T	SNRPB_ENST00000381342.2_3'UTR	NM_198216.1	NP_937859.1	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	232	Repeat-rich region.				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						ATTCCCGGGGGAGGGGGCCCT	0.547000													25	69					3.73148e-12	3.7491e-12	1	1	0
IGHD	3495	broad.mit.edu	37	14	106307412	106307412	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106307412C>T	ENST00000390556.2	-	0	625																											CTGTGGGGACCTTCCCGGCCA	0.662000													6	15					0	0	1	0	0
SEPT5	5413	broad.mit.edu	37	22	19707966	19707966	+	Silent	SNP	C	C	T	rs148378941		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19707966C>T	ENST00000438754.2	+	5	793	c.513C>T	c.(511-513)ccC>ccT	p.P171P	SEPT5_ENST00000383045.3_Silent_p.P171P|SEPT5_ENST00000455784.2_Silent_p.P162P|SEPT5_ENST00000406395.1_Silent_p.P162P	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	162					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					TCATCTCCCCCTTCGGGCATG	0.597000													22	59					0	0	1	0	0
BMPR2	659	broad.mit.edu	37	2	203420344	203420344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:203420344C>T	ENST00000374580.4	+	12	2495	c.1956C>T	c.(1954-1956)acC>acT	p.T652T	BMPR2_ENST00000374574.2_Intron	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	652					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						TTGGGCCAACCCCTGTCTGCT	0.443000													18	64					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57745893	57745893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57745893G>A	ENST00000281282.5	+	7	2145	c.2067G>A	c.(2065-2067)gtG>gtA	p.V689V		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	689						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TATTCCAGGTGAAGATGGAAC	0.517000													10	15					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065888	9065888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9065888C>T	ENST00000397910.4	-	3	21761	c.21558G>A	c.(21556-21558)gtG>gtA	p.V7186V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7188	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGAATCTCCACATTGGACG	0.507000													14	147					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138453020	138453020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138453020G>A	ENST00000344876.4	-	1	609	c.223C>T	c.(223-225)Cct>Tct	p.P75S	PCDH18_ENST00000412923.2_Missense_Mutation_p.P75S|PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	75	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ACAAGTAGAGGAGAATTTCCC	0.418000													56	133					0	0	1	0	0
DYRK4	8798	broad.mit.edu	37	12	4705767	4705767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4705767G>A	ENST00000540757.2	+	6	592	c.432G>A	c.(430-432)caG>caA	p.Q144Q	DYRK4_ENST00000010132.5_Silent_p.Q144Q|DYRK4_ENST00000543431.1_Silent_p.Q144Q	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	144	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			TTCACCAGCAGGCCCTGATGG	0.522000													17	24					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282195	152282195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152282195C>T	ENST00000368799.1	-	3	5202	c.5167G>A	c.(5167-5169)Gag>Aag	p.E1723K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1723	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGTGTCCCTCGCTGTCACTG	0.597000									Ichthyosis				144	343					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18182980	18182980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18182980C>T	ENST00000600835.1	-	10	1266	c.963G>A	c.(961-963)tcG>tcA	p.S321S	IL12RB1_ENST00000593993.1_Silent_p.S321S|IL12RB1_ENST00000430026.2_Silent_p.S321S|IL12RB1_ENST00000322153.6_Silent_p.S321S			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	321	Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CAAATTGGTTCGAGGAGATGA	0.627000													17	35					0	0	1	0	0
OR5K4	403278	broad.mit.edu	37	3	98072952	98072952	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98072952C>T	ENST00000354924.2	+	1	255	c.255C>T	c.(253-255)ttC>ttT	p.F85F	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						TAGAGAATTTCTTTTCTGAGG	0.433000													165	356					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18668094	18668094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18668094C>T	ENST00000308799.4	+	7	1779	c.1560C>T	c.(1558-1560)ttC>ttT	p.F520F	FBXW10_ENST00000395665.4_Silent_p.F491F|FBXW10_ENST00000301938.4_Silent_p.F491F|FBXW10_ENST00000395667.1_Silent_p.F491F			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	491										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						CACGAATCTTCGGTGGTCACC	0.493000													27	32					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140055526	140055526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140055526G>A	ENST00000371561.3	+	9	2313	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K	GRIN1_ENST00000350902.5_Missense_Mutation_p.E406K|GRIN1_ENST00000371555.4_Missense_Mutation_p.E427K|GRIN1_ENST00000315048.3_Missense_Mutation_p.E406K|GRIN1_ENST00000371560.3_Missense_Mutation_p.E427K|GRIN1_ENST00000371559.4_Missense_Mutation_p.E406K|GRIN1_ENST00000371546.4_Missense_Mutation_p.E427K|GRIN1_ENST00000371550.4_Missense_Mutation_p.E406K|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371553.3_Missense_Mutation_p.E427K	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	406					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GATCCACCAGGAGCCCTTCGT	0.627000													14	48					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147259245	147259245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:147259245C>T	ENST00000361727.3	+	12	2309	c.1793C>T	c.(1792-1794)tCc>tTc	p.S598F		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	598	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TACGAGCCTTCCTGTGAAGCC	0.448000										HNSCC(39;0.1)			10	72					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64418966	64418966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64418966C>T	ENST00000265459.6	-	14	3140	c.2679G>A	c.(2677-2679)atG>atA	p.M893I	AP001092.4_ENST00000433606.1_RNA|NRXN2_ENST00000377559.3_Missense_Mutation_p.M853I|NRXN2_ENST00000409571.1_Missense_Mutation_p.M886I|NRXN2_ENST00000377551.1_Missense_Mutation_p.M893I	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	893	Laminin G-like 4.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TGCACTGGTCCATGTAGGGCT	0.582000											OREG0021057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	37					0	0	1	0	0
GPR55	9290	broad.mit.edu	37	2	231775414	231775414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231775414G>A	ENST00000392040.1	-	2	456	c.264C>T	c.(262-264)tcC>tcT	p.S88S	GPR55_ENST00000392039.2_Silent_p.S88S	NM_005683.3	NP_005674.2	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	88					activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			endometrium(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		ACGGGAAGGGGGACTGTACCT	0.552000													24	57					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134896090	134896090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134896090G>A	ENST00000607359.1	+	6	1176	c.1176G>A	c.(1174-1176)agG>agA	p.R392R				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		ACTTGGGGAGGGGAGGCCTTT	0.587000													6	26					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57117372	57117372	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57117372G>A	ENST00000263314.2	+	7	739	c.705_splice	c.e7+1	p.T235_splice		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	235					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						TGGCGCGCACGGTGAGGACCT	0.642000											OREG0020966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	30					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	140990817	140990817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:140990817C>T	ENST00000389484.3	-	91	14709	c.13738G>A	c.(13738-13740)Gat>Aat	p.D4580N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4580					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCCTTTCATCAACACTTCCT	0.318000										TSP Lung(27;0.18)			15	55					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161300263	161300263	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:161300263G>A	ENST00000428797.2	+	6	751	c.396G>A	c.(394-396)aaG>aaA	p.K132K	GABRA1_ENST00000420560.1_Silent_p.K132K|GABRA1_ENST00000444819.1_Silent_p.K132K|GABRA1_ENST00000437025.2_Silent_p.K132K|GABRA1_ENST00000023897.6_Silent_p.K132K|GABRA1_ENST00000393943.4_Silent_p.K132K	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	132				Missing (in Ref. 4; CAA31925).	gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	ACAATGGAAAGAAGTCAGTGG	0.463000													9	55					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55658779	55658779	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55658779G>A	ENST00000449290.2	+	7	1122	c.1030G>A	c.(1030-1032)Gag>Aag	p.E344K	TRIM51_ENST00000244891.3_Missense_Mutation_p.E201K	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	344	B30.2/SPRY.					intracellular	zinc ion binding										ATATTATTGGGAGGTTCATAT	0.433000													56	143					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711684	20711684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20711684G>A	ENST00000315409.2	+	1	787	c.734G>A	c.(733-735)aGa>aAa	p.R245K		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		GCTGGTCGGAGAAAAGCCTTC	0.433000													45	379					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135266134	135266134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135266134G>A	ENST00000334270.2	-	7	2111	c.2072C>T	c.(2071-2073)cCc>cTc	p.P691L		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	691	Myb-like 2.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TAACTCCTGGGGAGACATCTT	0.408000													28	186					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846452	43846452	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43846452G>A	ENST00000389420.3	-	13	1806	c.1807C>T	c.(1807-1809)Cga>Tga	p.R603*	ADAMTS20_ENST00000553158.1_Nonsense_Mutation_p.R603*	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	603	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TTACATGATCGAAATTTCATC	0.398000													9	17					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703333	55703333	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55703333C>T	ENST00000301532.3	-	1	543	c.544G>A	c.(544-546)Gac>Aac	p.D182N		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GGAGGGAGGTCACAGAAAAAA	0.403000													11	47					0	0	1	0	0
TRPV3	162514	broad.mit.edu	37	17	3430213	3430213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3430213G>A	ENST00000301365.4	-	12	1643	c.1512C>T	c.(1510-1512)gcC>gcT	p.A504A	TRPV3_ENST00000572519.1_Silent_p.A504A|TRPV3_ENST00000576742.1_Silent_p.A504A			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	504						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	GCAGGAAGATGGCAATGCCCT	0.567000													9	6					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25959211	25959211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25959211G>A	ENST00000356865.6	-	10	2065	c.1954C>T	c.(1954-1956)Ctc>Ttc	p.L652F		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	652					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TCCAGCCTGAGAAGCATGCCG	0.672000													14	46					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681681	55681681	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55681681G>A	ENST00000344514.1	-	1	377	c.378C>T	c.(376-378)atC>atT	p.I126I		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GGGGGTTGATGATGGCCTTGT	0.458000													29	49					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22945069	22945069	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22945069C>T	ENST00000313077.7	+	12	1265	c.1140C>T	c.(1138-1140)gcC>gcT	p.A380A	CYFIP1_ENST00000560848.1_Silent_p.A380A	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	380					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GCCAGGAGGCCCAGAAGACGG	0.701000													3	5					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990476	990476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:990476G>A	ENST00000190165.2	+	2	928	c.890G>A	c.(889-891)cGa>cAa	p.R297Q		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	297					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GGAGCAGAGCGAACTTCCGCA	0.582000													13	56					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551788	248551788	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248551788G>A	ENST00000355728.2	+	1	879	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGTCTGAGGAACAGGGATG	0.458000													13	59					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88847478	88847478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:88847478G>A	ENST00000333190.4	+	2	727	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	40						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GGATTTTGCAGAAAAGAAGTC	0.348000										HNSCC(36;0.09)			26	70					0	0	1	0	0
POLL	27343	broad.mit.edu	37	10	103339570	103339570	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103339570G>A	ENST00000370162.3	-	9	1862	c.1368C>T	c.(1366-1368)ttC>ttT	p.F456F	POLL_ENST00000370172.1_Silent_p.F368F|POLL_ENST00000370158.3_Silent_p.F181F|POLL_ENST00000339310.3_Silent_p.F179F|POLL_ENST00000299206.4_Silent_p.F456F|DPCD_ENST00000470165.1_Intron|POLL_ENST00000463515.1_5'UTR|POLL_ENST00000456836.2_Silent_p.F193F|POLL_ENST00000370168.3_Silent_p.F129F|DPCD_ENST00000416979.2_Intron|POLL_ENST00000370169.1_Silent_p.F456F	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	456					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		CATCTGTGAGGAACCCTGGCC	0.652000								DNA polymerases (catalytic subunits)					7	42					0	0	1	0	0
MAPK8IP1	9479	broad.mit.edu	37	11	45923603	45923603	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:45923603C>T	ENST00000395629.2	+	4	895	c.565C>T	c.(565-567)Ctg>Ttg	p.L189L	MAPK8IP1_ENST00000241014.2_Silent_p.L199L			Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting protein 1	199	JNK-binding domain (JBD).				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		ATCCTCACCCCTGAAGACAGG	0.532000													74	100					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59221646	59221646	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59221646C>G	ENST00000262717.4	+	12	2522	c.2124C>G	c.(2122-2124)ctC>ctG	p.L708L	CDH20_ENST00000536675.2_Silent_p.L708L|CDH20_ENST00000538374.1_Silent_p.L708L			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	708					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TCGAGAGCCTCTCCCGCTACG	0.687000													14	51					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413782	48413782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48413782G>A	ENST00000249598.1	-	2	1245	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	362					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CAGCCAAGGGGAAGAAGCAGC	0.582000													19	51					0	0	1	0	0
NR4A1	3164	broad.mit.edu	37	12	52451238	52451238	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52451238C>T	ENST00000545748.1	+	7	2621	c.1626C>T	c.(1624-1626)gcC>gcT	p.A542A	NR4A1_ENST00000360284.3_Silent_p.A501A|NR4A1_ENST00000550082.1_Silent_p.A501A|NR4A1_ENST00000394824.2_Silent_p.A488A|NR4A1_ENST00000243050.1_Silent_p.A488A|NR4A1_ENST00000394825.1_Silent_p.A488A			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	488					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GTATCCTGGCCTTCTCAAGGT	0.612000													12	56					0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155533028	155533028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155533028C>T	ENST00000404648.3	-	4	569	c.330G>A	c.(328-330)ttG>ttA	p.L110L	FGG_ENST00000336098.3_Silent_p.L110L|FGG_ENST00000407946.1_Silent_p.L110L|FGG_ENST00000405164.1_Silent_p.L110L	NM_000509.4	NP_000500.2	P02679	FIBG_HUMAN	fibrinogen gamma chain	110					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TCCTGGACTTCAAAGTAGCAG	0.318000													9	31					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32089086	32089086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32089086G>A	ENST00000375201.4	-	6	554	c.509C>T	c.(508-510)tCc>tTc	p.S170F	ATF6B_ENST00000375203.3_Missense_Mutation_p.S173F			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	173					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						AGAGTTGACGGAAGAACATGG	0.537000													9	21					0	0	1	0	0
FAM53B	9679	broad.mit.edu	37	10	126370409	126370409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:126370409G>A	ENST00000337318.3	-	4	884	c.673C>T	c.(673-675)Ctg>Ttg	p.L225L	RP11-12J10.3_ENST00000494792.1_3'UTR|FAM53B_ENST00000280780.6_Silent_p.L225L|FAM53B_ENST00000392754.3_Silent_p.L225L	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	225										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		GACCGCTGCAGGTCCAGCCGG	0.642000													5	14					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702138	181702138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181702138G>A	ENST00000526775.1	+	19	3024	c.2859G>A	c.(2857-2859)acG>acA	p.T953T	CACNA1E_ENST00000367567.4_Silent_p.T579T|CACNA1E_ENST00000358338.5_Silent_p.T904T|CACNA1E_ENST00000367570.1_Silent_p.T972T|CACNA1E_ENST00000360108.3_Silent_p.T953T|CACNA1E_ENST00000367573.2_Silent_p.T972T|CACNA1E_ENST00000357570.5_Silent_p.T923T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	972					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.T972T(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGGAGCCAACGATCCAAGAAG	0.562000													10	33					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761127	92761127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92761127G>A	ENST00000318238.4	-	5	5374	c.4158C>T	c.(4156-4158)gcC>gcT	p.A1386A	SAMD9L_ENST00000411955.1_Silent_p.A1386A|SAMD9L_ENST00000437805.1_Silent_p.A1386A	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1386										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GAATAATGTTGGCCAAAATGG	0.383000													17	251					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493558	55493558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55493558G>A	ENST00000543010.1	+	6	635	c.492G>A	c.(490-492)ttG>ttA	p.L164L	NLRP2_ENST00000263437.6_Silent_p.L161L|NLRP2_ENST00000537859.1_Silent_p.L142L|NLRP2_ENST00000391721.4_Silent_p.L140L|NLRP2_ENST00000448584.2_Silent_p.L164L|NLRP2_ENST00000339757.7_Silent_p.L142L|NLRP2_ENST00000538819.1_Silent_p.L140L|NLRP2_ENST00000427260.2_Silent_p.L141L	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	164					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGTATATATTGAAGACGAAGT	0.453000													103	239					0	0	1	0	0
AMPD1	270	broad.mit.edu	37	1	115238117	115238117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115238117G>A	ENST00000369538.3	-	1	122	c.75C>T	c.(73-75)atC>atT	p.I25I	AMPD1_ENST00000353928.6_5'UTR|AMPD1_ENST00000520113.2_Silent_p.I25I	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	0					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TTGATTCTAGGATAGCACAGT	0.388000													39	141					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8174515	8174515	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8174515C>T	ENST00000600128.1	-	35	4870	c.4456_splice	c.e35+1	p.D1486_splice	FBN3_ENST00000601739.1_Splice_Site_p.D1486_splice|FBN3_ENST00000270509.2_Splice_Site_p.D1486_splice			Q75N90	FBN3_HUMAN	fibrillin 3	1486						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ATGGACTCACCCACGCAGCCC	0.567000													30	74					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24250784	24250784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24250784G>A	ENST00000256412.4	+	3	437	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	ADAMDEC1_ENST00000522298.1_5'UTR|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000538205.1_5'UTR|RP11-624C23.1_ENST00000519689.1_RNA	NM_014479.3	NP_055294.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	73					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		GGAAAGGTATGAACCTGAAGT	0.289000													25	71					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	47990456	47990456	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47990456G>A	ENST00000371741.4	-	2	1807	c.1641C>T	c.(1639-1641)acC>acT	p.T547T		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	547					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTGACTCCTTGGTATTGAGGA	0.517000													75	195					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723505	48723505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48723505C>T	ENST00000335017.1	+	1	743	c.431C>T	c.(430-432)cCc>cTc	p.P144L		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	144	Arg-rich.				chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						ACGCGCGCTCCCTGGAGGACC	0.721000													5	12					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77885578	77885578	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:77885578G>A	ENST00000354212.4	-	10	1982	c.1729C>T	c.(1729-1731)Cag>Tag	p.Q577*	MAGI2_ENST00000535697.1_Nonsense_Mutation_p.Q414*|MAGI2_ENST00000419488.1_Nonsense_Mutation_p.Q577*|MAGI2_ENST00000536571.1_Nonsense_Mutation_p.Q409*|MAGI2_ENST00000522391.1_Nonsense_Mutation_p.Q577*	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	577						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CCGTCTAGCTGACCATCAGTT	0.488000													16	41					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101813497	101813497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101813497G>A	ENST00000506729.1	-	3	856	c.685C>T	c.(685-687)Ctg>Ttg	p.L229L	SLCO6A1_ENST00000379810.1_Intron|SLCO6A1_ENST00000514551.1_Intron|SLCO6A1_ENST00000513675.1_Intron|SLCO6A1_ENST00000389019.3_Intron|SLCO6A1_ENST00000379807.3_Silent_p.L229L			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	229						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AAGAAAGACAGGTATTTTGAT	0.363000													39	160					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046640	42046640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42046640G>A	ENST00000372584.1	-	3	4843	c.3829C>T	c.(3829-3831)Ccc>Tcc	p.P1277S	HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1277S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1277S|HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1277S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1277					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TCTGTGCTGGGGGAGAGGCCA	0.617000													5	49					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52519592	52519592	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52519592G>A	ENST00000270649.6	-	5	1803	c.1259C>T	c.(1258-1260)aCt>aTt	p.T420I	ZNF614_ENST00000356322.6_Intron	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	420					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TCCTGTATGAGTTCGCTGATG	0.413000													29	290					0	0	1	0	0
TPSG1	25823	broad.mit.edu	37	16	1272244	1272244	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1272244G>A	ENST00000234798.4	-	5	613	c.609C>T	c.(607-609)atC>atT	p.I203I		NM_012467.3	NP_036599.3	Q9NRR2	TRYG1_HUMAN	tryptase gamma 1	203	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			liver(1)|lung(2)|skin(1)	4		Hepatocellular(780;0.00369)				CGGGCTGAAGGATGCTGCCCC	0.706000													7	39					0	0	1	0	0
TNNI2	7136	broad.mit.edu	37	11	1862398	1862398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1862398G>A	ENST00000381906.1	+	7	483	c.414G>A	c.(412-414)agG>agA	p.R138R	TNNI2_ENST00000381911.1_Silent_p.R138R|TNNI2_ENST00000252898.7_Silent_p.R138R|TNNI2_ENST00000381905.3_Silent_p.R138R	NM_001145829.1	NP_001139301.1	P48788	TNNI2_HUMAN	troponin I type 2 (skeletal, fast)	138					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding			lung(8)|prostate(1)|urinary_tract(1)	10		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGACCTGAGGGCCAACCTGA	0.647000													19	29					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101606801	101606801	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101606801G>A	ENST00000370449.4	+	30	4343	c.4230G>A	c.(4228-4230)ttG>ttA	p.L1410L		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1410	ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGAAGGCCTTGGAGCTGGCTC	0.517000													63	183					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36940319	36940319	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36940319C>T	ENST00000262865.4	+	5	681	c.592C>T	c.(592-594)Cga>Tga	p.R198*	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	198					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				GTCTGCGCTTCGAAACAAGAT	0.507000													10	83					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360859	27360859	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27360859G>T	ENST00000335524.3	-	3	864	c.339C>A	c.(337-339)ccC>ccA	p.P113P		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	113	Pro-rich.									cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					agtggttggagggagaggatg	0.577000													5	17					0.014758	0.0147615	1	1	0
BHMT	635	broad.mit.edu	37	5	78415084	78415084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78415084C>T	ENST00000274353.5	+	3	276	c.169C>T	c.(169-171)Cgc>Tgc	p.R57C	DMGDH_ENST00000520388.1_Intron|BHMT_ENST00000524080.1_Intron	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	57	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	TCTCCCAGTTCGCCAGCTTCA	0.438000													30	100					0	0	1	0	0
NR6A1	2649	broad.mit.edu	37	9	127300526	127300526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127300526G>A	ENST00000487099.2	-	6	826	c.669C>T	c.(667-669)taC>taT	p.Y223Y	NR6A1_ENST00000416460.2_Silent_p.Y218Y|NR6A1_ENST00000373584.3_Silent_p.Y219Y|NR6A1_ENST00000344523.4_Silent_p.Y222Y	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	223	Sufficient for interaction with UIMC1 (By similarity).				cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						GTATATATTGGTAATGTGGAG	0.493000													23	66					0	0	1	0	0
PIGK	10026	broad.mit.edu	37	1	77620246	77620246	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:77620246G>A	ENST00000370812.3	-	9	897	c.874C>T	c.(874-876)Cag>Tag	p.Q292*	PIGK_ENST00000359130.1_Nonsense_Mutation_p.Q292*|PIGK_ENST00000478391.1_5'UTR|PIGK_ENST00000445065.1_Nonsense_Mutation_p.Q198*|PIGK_ENST00000370813.5_Nonsense_Mutation_p.Q216*	NM_005482.2	NP_005473.1	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class K	292					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	19						GGATCCCTCTGAAAAAGATCA	0.358000													19	61					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46916020	46916020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46916020C>T	ENST00000307522.3	-	1	821	c.48G>A	c.(46-48)gaG>gaA	p.E16E		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	16						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		ccagcctgacctcccggggga	0.602000													8	60					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692569	135692569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135692569G>A	ENST00000513104.1	-	2	789	c.507C>T	c.(505-507)atC>atT	p.I169I	TRPC7_ENST00000355180.3_Silent_p.I169I|TRPC7_ENST00000426057.2_Silent_p.I169I	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	169					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCGCCGCCAGGATGATGGGCG	0.632000													65	161					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382613	22382613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22382613C>T	ENST00000328795.4	+	1	232	c.141C>T	c.(139-141)ttC>ttT	p.F47F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCATTATTTTCACCATAAGGT	0.458000													78	231					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10357980	10357980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10357980C>T	ENST00000255381.2	-	22	2693	c.2583G>A	c.(2581-2583)gaG>gaA	p.E861E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	861					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CTTTGGTTTTCTCAAATTCTT	0.438000													40	100					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53340208	53340208	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:53340208C>T	ENST00000566029.1	+	32	6888	c.6679C>T	c.(6679-6681)Cag>Tag	p.Q2227*	CHD9_ENST00000564845.1_Nonsense_Mutation_p.Q2227*|CHD9_ENST00000447540.1_Nonsense_Mutation_p.Q2228*|CHD9_ENST00000398510.3_Nonsense_Mutation_p.Q2227*			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2227					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GAGCACTACCCAGGATGAGAC	0.398000													25	48					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121440964	121440964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121440964G>A	ENST00000260197.7	+	23	3451	c.3322G>A	c.(3322-3324)Gat>Aat	p.D1108N	SORL1_ENST00000525532.1_Missense_Mutation_p.D52N	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1108	LDL-receptor class A 1.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGACATGAGCGATGAGAGAAA	0.507000													34	83					0	0	1	0	0
ZNF839	55778	broad.mit.edu	37	14	102802155	102802155	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102802155C>T	ENST00000262236.5	+	5	1646	c.1291C>T	c.(1291-1293)Ctg>Ttg	p.L431L	ZNF839_ENST00000442396.2_Silent_p.L547L|ZNF839_ENST00000558850.1_Silent_p.L431L|ZNF839_ENST00000559185.1_Silent_p.L431L	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	431						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CCAGGAGACCCTGGAAATAAA	0.413000													20	40					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71510360	71510360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71510360C>T	ENST00000396073.3	+	9	3498	c.3217C>T	c.(3217-3219)Cca>Tca	p.P1073S	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	1073					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			CACCGGAACTCCATCTAGCGA	0.433000													21	95					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70488360	70488360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70488360G>A	ENST00000260128.4	+	6	1045	c.328G>A	c.(328-330)Gag>Aag	p.E110K	SULF1_ENST00000458141.2_Missense_Mutation_p.E110K|SULF1_ENST00000419716.3_Missense_Mutation_p.E110K|SULF1_ENST00000402687.4_Missense_Mutation_p.E110K	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	110					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CACCAACAACGAGAACTGCTC	0.507000													13	61					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173679074	173679074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:173679074C>T	ENST00000264111.6	+	4	552	c.365C>T	c.(364-366)cCc>cTc	p.P122L	RAPGEF4_ENST00000409036.1_Missense_Mutation_p.P122L|RAPGEF4_ENST00000397081.3_Missense_Mutation_p.P122L			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	122					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GACAACACACCCCGCCATGCA	0.517000													38	94					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751521	140751521	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140751521C>T	ENST00000576222.1	+	1	1691	c.1560C>T	c.(1558-1560)ttC>ttT	p.F520F	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGAGCCTTCGACCACGAGC	0.682000													8	70					0	0	1	0	0
TLDC1	57707	broad.mit.edu	37	16	84520383	84520383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84520383G>A	ENST00000343629.6	-	5	994	c.812C>T	c.(811-813)tCg>tTg	p.S271L	TLDC1_ENST00000535580.1_Missense_Mutation_p.S244L	NM_020947.3	NP_065998.3			TBC/LysM-associated domain containing 1																		GAGCTCAGACGAAAAGAGCAG	0.597000													18	37					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121944316	121944316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121944316C>T	ENST00000442488.2	-	1	243	c.176G>A	c.(175-177)gGg>gAg	p.G59E	FEZF1_ENST00000331178.4_Missense_Mutation_p.G59E|FEZF1-AS1_ENST00000428449.1_RNA|FEZF1_ENST00000427185.2_Missense_Mutation_p.G59E	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	59					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						CTTGGGTTCCCCCTTGGGTAA	0.617000													36	109					0	0	1	0	0
NAT6	24142	broad.mit.edu	37	3	50334496	50334496	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50334496G>A	ENST00000443842.1	-	2	1206	c.399C>T	c.(397-399)ccC>ccT	p.P133P	NAT6_ENST00000443094.2_Silent_p.P133P|NAT6_ENST00000417393.1_Silent_p.P133P|HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000450982.1_Intron|NAT6_ENST00000354862.4_Silent_p.P155P|HYAL3_ENST00000415204.1_Intron|HYAL3_ENST00000359051.3_Intron|HYAL3_ENST00000336307.1_Intron					N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		AGAGGCTCTGGGGCTGGTTCA	0.682000													7	18					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27528496	27528496	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27528496G>A	ENST00000296098.4	+	6	1050	c.780G>A	c.(778-780)gaG>gaA	p.E260E	TRIM54_ENST00000380075.2_Silent_p.E218E	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	218					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAGGTTTGAGAGCCTGTGCG	0.627000													13	13					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171154906	171154906	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171154906G>A	ENST00000441535.1	+	2	171	c.54G>A	c.(52-54)ctG>ctA	p.L18L	FMO2_ENST00000209929.7_Silent_p.L18L|FMO2_ENST00000529935.1_Intron|RP1-45C12.1_ENST00000455124.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	18					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TAATTTCTCTGAAGTGCTGTG	0.463000													57	160					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26619945	26619945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26619945G>A	ENST00000256737.3	+	15	2333	c.1481G>A	c.(1480-1482)aGg>aAg	p.R494K	ANO3_ENST00000537978.1_Missense_Mutation_p.R478K|ANO3_ENST00000531568.1_Missense_Mutation_p.R348K|ANO3_ENST00000525139.1_Missense_Mutation_p.R478K	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	494						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						AAAAGGAGAAGGAGTATACTG	0.353000													10	119					0	0	1	0	0
ADCK4	79934	broad.mit.edu	37	19	41209632	41209632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41209632G>A	ENST00000324464.3	-	8	1006	c.705C>T	c.(703-705)gcC>gcT	p.A235A	ADCK4_ENST00000243583.6_Silent_p.A194A|ADCK4_ENST00000450541.1_Silent_p.A194A	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	235	Protein kinase.					integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GGATCTTCACGGCCACCTCCG	0.657000													15	69					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17596843	17596843	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17596843C>T	ENST00000375460.3	+	7	808	c.768C>T	c.(766-768)ttC>ttT	p.F256F		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	256					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GCCTGTCCTTCCCTGATGCCG	0.582000													31	65					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47765403	47765403	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47765403C>T	ENST00000273857.4	-	4	609	c.610G>A	c.(610-612)Gat>Aat	p.D204N	CORIN_ENST00000502252.1_Missense_Mutation_p.D137N|CORIN_ENST00000505909.1_Missense_Mutation_p.D204N|CORIN_ENST00000504584.1_Missense_Mutation_p.D204N|CORIN_ENST00000508498.1_Missense_Mutation_p.D65N	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	204	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TACCTGTCATCGCCATCAATG	0.413000													6	17					0	0	1	0	0
OR5M8	219484	broad.mit.edu	37	11	56258362	56258362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56258362G>A	ENST00000327216.2	-	1	509	c.485C>T	c.(484-486)aCc>aTc	p.T162I		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					TAGGTTGTAGGTCCACATGGT	0.507000													32	103					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489440	237489440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237489440C>T	ENST00000272928.3	+	2	642	c.332C>T	c.(331-333)cCc>cTc	p.P111L		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		AACCAGTGGCCCATGGGCGAG	0.572000													29	107					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144060402	144060402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:144060402G>A	ENST00000056217.5	+	2	814	c.640G>A	c.(640-642)Gag>Aag	p.E214K		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	214					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					GCCACCTGAGGAGCTGCAGGA	0.557000													46	218					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18378199	18378199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18378199G>A	ENST00000392413.3	-	3	366	c.151C>T	c.(151-153)Cct>Tct	p.P51S	KIAA1683_ENST00000600328.2_Missense_Mutation_p.P51S|KIAA1683_ENST00000600359.2_Missense_Mutation_p.P5S	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	51						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GGCTGTGGAGGCGCTTTCTCC	0.667000													48	107					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21631030	21631030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21631030G>A	ENST00000328843.6	+	14	2533	c.2502G>A	c.(2500-2502)gtG>gtA	p.V834V	DNAH11_ENST00000409508.3_Silent_p.V834V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	834	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGAAAAACGTGAAGGTGATCC	0.607000									Kartagener syndrome				21	56					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136562339	136562339	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136562339G>A	ENST00000264162.2	-	10	4472	c.4462C>T	c.(4462-4464)Cag>Tag	p.Q1488*		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1488	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CACCATACCTGGGGCTGGATG	0.547000													15	33					0	0	1	0	0
TNFRSF10B	8795	broad.mit.edu	37	8	22926370	22926370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22926370C>T	ENST00000276431.4	-	1	322	c.38G>A	c.(37-39)gGg>gAg	p.G13E	TNFRSF10B_ENST00000347739.3_Missense_Mutation_p.G13E|TNFRSF10B_ENST00000542226.1_5'UTR|RP11-875O11.2_ENST00000501897.1_RNA	NM_003842.4|NM_147187.2	NP_003833.4|NP_671716.2	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily, member 10b	13					activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding			NS(1)|endometrium(2)|large_intestine(7)|liver(1)|lung(3)|skin(1)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		TTTCCGGGCCCCCGAAGCGGC	0.677000													23	33					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78069181	78069181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78069181G>A	ENST00000397545.4	+	18	2979	c.2952G>A	c.(2950-2952)aaG>aaA	p.K984K		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	984					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGGACAGGAAGGCGCTCACCC	0.627000													22	55					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64417930	64417930	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64417930G>A	ENST00000265459.6	-	15	3560	c.3099C>T	c.(3097-3099)ctC>ctT	p.L1033L	AP001092.4_ENST00000433606.1_RNA|NRXN2_ENST00000377559.3_Silent_p.L993L|NRXN2_ENST00000409571.1_Silent_p.L1026L|NRXN2_ENST00000377551.1_Silent_p.L1033L	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1033	Laminin G-like 5.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CTTTGAGATCGAGGTTTCGGG	0.632000													36	137					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119540121	119540121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119540121C>T	ENST00000267260.4	+	2	600	c.212C>T	c.(211-213)cCc>cTc	p.P71L	RP11-364C11.2_ENST00000537730.1_RNA	NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	71					cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						GCCACCGAGCCCTTGGGCACC	0.542000													9	32					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81864696	81864696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81864696G>A	ENST00000555447.1	-	3	443	c.31C>T	c.(31-33)Cac>Tac	p.H11Y	STON2_ENST00000267540.2_Missense_Mutation_p.H11Y	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	11					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TCTGACTGGTGGGTGGCAATC	0.517000													18	50					0	0	1	0	0
C1orf146	388649	broad.mit.edu	37	1	92707838	92707838	+	Missense_Mutation	SNP	G	G	A	rs41286799		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92707838G>A	ENST00000370375.3	+	3	284	c.136G>A	c.(136-138)Gga>Aga	p.G46R	C1orf146_ENST00000370373.2_5'UTR	NM_001012425.1	NP_001012425.1	Q5VVC0	CA146_HUMAN	chromosome 1 open reading frame 146	46										breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		AGTGGAAAATGGATCAATTAT	0.299000													12	48					0	0	1	0	0
NOL10	79954	broad.mit.edu	37	2	10712207	10712207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:10712207G>A	ENST00000345985.3	-	20	2017	c.1907C>T	c.(1906-1908)tCg>tTg	p.S636L	NOL10_ENST00000381685.5_Missense_Mutation_p.S686L|NOL10_ENST00000538384.1_Missense_Mutation_p.S660L|NOL10_ENST00000542668.1_Missense_Mutation_p.S636L	NM_001261394.1	NP_001248323.1	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	686						nucleolus						Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		TCAATGAAACGACCGTCCTCT	0.498000													67	166					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53572226	53572226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53572226G>A	ENST00000601421.1	-	3	2329	c.1453C>T	c.(1453-1455)Cgt>Tgt	p.R485C	ZNF160_ENST00000429604.1_Missense_Mutation_p.R521C|ZNF160_ENST00000418871.1_Missense_Mutation_p.R521C|ZNF160_ENST00000599056.1_Missense_Mutation_p.R521C			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	521					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R521C(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		AGACTTGAACGAACACTGAAG	0.398000													16	148					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416282	178416282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178416282G>A	ENST00000231188.5	-	5	1315	c.1137C>T	c.(1135-1137)tcC>tcT	p.S379S	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Silent_p.S379S	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	379					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		ATTTGCGGGTGGAATCGTCTG	0.612000													21	36					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61828486	61828486	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61828486C>T	ENST00000280772.1	-	37	12344	c.12153G>A	c.(12151-12153)acG>acA	p.T4051T	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4051					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TAGCAGACTTCGTTGTAACCG	0.478000													66	166					0	0	1	0	0
PGD	5226	broad.mit.edu	37	1	10477453	10477453	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10477453C>T	ENST00000538557.1	+	10	1201	c.957C>T	c.(955-957)atC>atT	p.I319I	PGD_ENST00000270776.8_Silent_p.I332I|PGD_ENST00000541529.1_Silent_p.I310I|PGD_ENST00000498356.1_3'UTR			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	332					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		CTTCCAAGATCATCTCTTACG	0.507000													71	188					0	0	1	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148748050	148748050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148748050C>T	ENST00000514349.1	+	5	1627	c.1048C>T	c.(1048-1050)Cat>Tat	p.H350Y	PCYOX1L_ENST00000274569.4_Missense_Mutation_p.H440Y			Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like	440					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			breast(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTGCACTCCATGACCAGCT	0.607000													29	78					0	0	1	0	0
NEK9	91754	broad.mit.edu	37	14	75563921	75563921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75563921G>A	ENST00000238616.5	-	17	2213	c.2055C>T	c.(2053-2055)acC>acT	p.T685T		NM_033116.4	NP_149107.4	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	685					cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00718)		TCTCTGTGGGGGTCATTGCCA	0.498000													23	39					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23285498	23285498	+	RNA	SNP	T	T	A	rs116993237	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23285498T>A	ENST00000560464.1	-	0	5097																											CGTCACAGTGTGCGTGCTTGT	0.572000													4	42					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3227866	3227866	+	Missense_Mutation	SNP	C	C	T	rs149129110		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3227866C>T	ENST00000217939.6	-	7	8532	c.8378G>A	c.(8377-8379)gGa>gAa	p.G2793E		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2793	Ig-like C2-type 12.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGTCAGTGATCCCTGGGGGTG	0.502000													25	14					0	0	1	0	0
SLC47A1	55244	broad.mit.edu	37	17	19480671	19480671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:19480671G>A	ENST00000270570.4	+	17	1604	c.1518G>A	c.(1516-1518)acG>acA	p.T506T	SLC47A1_ENST00000571335.1_Silent_p.T252T|SLC47A1_ENST00000395585.1_Silent_p.T506T|SLC47A1_ENST00000436810.2_3'UTR|SLC47A1_ENST00000575023.1_Silent_p.T204T|SLC47A1_ENST00000457293.1_Silent_p.T506T|RP11-1113L8.1_ENST00000574267.1_RNA	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	506						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					GAATTTTAACGAACGATGTTG	0.443000													22	60					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85997426	85997426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85997426C>T	ENST00000372105.3	-	2	160	c.139G>A	c.(139-141)Gac>Aac	p.D47N		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	47	LRRNT.					integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						ATGTCGGGGTCGTTGCACACT	0.657000													17	55					0	0	1	0	0
MRPS35	60488	broad.mit.edu	37	12	27872744	27872744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:27872744C>T	ENST00000081029.3	+	4	396	c.325C>T	c.(325-327)Ccc>Tcc	p.P109S	MRPS35_ENST00000538315.1_Missense_Mutation_p.P109S	NM_021821.3	NP_068593.2	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35	109					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit				breast(1)|endometrium(1)|kidney(1)|lung(2)|urinary_tract(1)	6	Lung SC(9;0.0873)					ATTTAAGATTCCCAATTTTCT	0.274000													15	67					0	0	1	0	0
ZFP3	124961	broad.mit.edu	37	17	4995352	4995352	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4995352C>T	ENST00000318833.3	+	2	889	c.553C>T	c.(553-555)Cga>Tga	p.R185*		NM_153018.2	NP_694563.1	Q96NJ6	ZFP3_HUMAN	ZFP3 zinc finger protein	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(3)|prostate(1)	20						TTCAAGCCTTCGACGGCACCT	0.398000													49	50					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9117527	9117527	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9117527G>A	ENST00000377424.4	-	3	452	c.273C>T	c.(271-273)ccC>ccT	p.P91P	SLC2A5_ENST00000535586.1_Intron|SLC2A5_ENST00000377414.3_Silent_p.P91P	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	91					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TATTCACCAAGGGGCCGACCA	0.473000													19	33					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17462538	17462538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:17462538G>A	ENST00000262545.2	+	12	2055	c.1740G>A	c.(1738-1740)caG>caA	p.Q580Q	PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000536609.1_Silent_p.Q545Q|PCSK2_ENST00000377899.1_Silent_p.Q561Q	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	580					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCGCCCCGCAGAAGGGGGTGC	0.617000													9	28					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59203811	59203811	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59203811G>A	ENST00000262717.4	+	8	1755	c.1357G>A	c.(1357-1359)Gac>Aac	p.D453N	CDH20_ENST00000536675.2_Missense_Mutation_p.D453N|CDH20_ENST00000538374.1_Missense_Mutation_p.D453N			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	453	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				AAGACCCCTAGACCGGGAAGA	0.418000													56	135					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181539	140181539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140181539G>A	ENST00000522353.2	+	1	757	c.757G>A	c.(757-759)Gaa>Aaa	p.E253K	PCDHA3_ENST00000532566.2_Missense_Mutation_p.E253K|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATTACTCGAAAATGCACC	0.443000													24	53					0	0	1	0	0
MYL9	10398	broad.mit.edu	37	20	35177519	35177519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35177519C>T	ENST00000279022.2	+	4	490	c.386C>T	c.(385-387)aCc>aTc	p.T129I	RP5-977B1.7_ENST00000425233.1_RNA|RP5-977B1.7_ENST00000439595.1_RNA|MYL9_ENST00000346786.2_Missense_Mutation_p.T75I	NM_006097.4	NP_006088.2	P24844	MYL9_HUMAN	myosin, light chain 9, regulatory	129	EF-hand 2.				axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)	8	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CTGCTCACCACCATGGGTGAC	0.582000													23	60					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44890982	44890982	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44890982C>T	ENST00000330997.4	-	4	1489	c.1425G>A	c.(1423-1425)caG>caA	p.Q475Q	CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000591679.1_Silent_p.Q482Q|ZNF285_ENST00000544719.2_Silent_p.Q475Q	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						TGTGAACTCTCTGATGAGTGT	0.403000													13	97					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113508735	113508735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113508735G>A	ENST00000505019.1	-	12	3603	c.3478C>T	c.(3478-3480)Cca>Tca	p.P1160S		NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	0										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		ACTCTGTTTGGAGTAGCCACG	0.408000													87	155					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427635	119427635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119427635G>A	ENST00000369429.3	-	8	1538	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F	TBX15_ENST00000207157.3_Missense_Mutation_p.S404F			Q96SF7	TBX15_HUMAN	T-box 15	510						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GTTGTGAAGGGAGAAGGCATT	0.527000													20	35					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61822884	61822884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61822884G>A	ENST00000280772.1	-	40	12771	c.12580C>T	c.(12580-12582)Cat>Tat	p.H4194Y	ANK3_ENST00000503366.1_Missense_Mutation_p.H1582Y|ANK3_ENST00000373827.2_Missense_Mutation_p.H1575Y|ANK3_ENST00000355288.2_Missense_Mutation_p.H715Y	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4194					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACAGGGTCATGGAAAACATTG	0.328000													8	27					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250110	140250110	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140250110C>T	ENST00000398640.2	+	1	1422	c.1422C>T	c.(1420-1422)ttC>ttT	p.F474F	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCACATCTTCACAGTGTCGG	0.662000													58	139					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88476372	88476372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88476372C>T	ENST00000394480.1	-	16	2081	c.1760G>A	c.(1759-1761)aGg>aAg	p.R587K	NTRK3_ENST00000558676.1_Missense_Mutation_p.R579K|NTRK3_ENST00000357724.2_Missense_Mutation_p.R579K|NTRK3_ENST00000355254.2_Missense_Mutation_p.R587K|NTRK3_ENST00000542733.2_Missense_Mutation_p.R489K|NTRK3_ENST00000360948.2_Missense_Mutation_p.R587K|NTRK3_ENST00000557856.1_Missense_Mutation_p.R579K	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	587	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTCGGCCTCCCTCTGGAAATC	0.552000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			6	90					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30024717	30024717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:30024717G>A	ENST00000346128.6	-	15	2411	c.1937C>T	c.(1936-1938)cCt>cTt	p.P646L	TJP1_ENST00000356107.6_Missense_Mutation_p.P646L|TJP1_ENST00000400011.2_Missense_Mutation_p.P650L|TJP1_ENST00000545208.2_Missense_Mutation_p.P646L	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	646	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		AATGGTTACAGGCCTCAGAAA	0.368000													19	83					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204913519	204913519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204913519G>A	ENST00000367172.4	+	3	404	c.76G>A	c.(76-78)Gaa>Aaa	p.E26K	NFASC_ENST00000404076.1_Missense_Mutation_p.E26K|NFASC_ENST00000513543.1_Missense_Mutation_p.E26K|NFASC_ENST00000367171.4_Missense_Mutation_p.E26K|NFASC_ENST00000403080.1_Missense_Mutation_p.E26K|NFASC_ENST00000339876.6_Missense_Mutation_p.E26K|NFASC_ENST00000539706.1_Missense_Mutation_p.E26K|NFASC_ENST00000404907.1_Missense_Mutation_p.E26K|NFASC_ENST00000360049.4_Missense_Mutation_p.E26K|NFASC_ENST00000367170.4_Missense_Mutation_p.E26K|NFASC_ENST00000401399.1_Missense_Mutation_p.E26K|NFASC_ENST00000367169.4_Missense_Mutation_p.E26K|NFASC_ENST00000338586.6_Missense_Mutation_p.E26K|NFASC_ENST00000338515.6_Missense_Mutation_p.E26K			O94856	NFASC_HUMAN	neurofascin	26					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.E26K(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CGGAGCCATCGAAATTCCTAT	0.597000													7	20					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55280655	55280655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55280655C>T	ENST00000358193.3	+	8	1047	c.993C>T	c.(991-993)ttC>ttT	p.F331F	C1orf177_ENST00000371273.3_Silent_p.F331F	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	331										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						AGCCCCCATTCCTGTTGACCT	0.542000													50	115					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109271457	109271457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109271457G>A	ENST00000370017.3	+	8	1850	c.1573G>A	c.(1573-1575)Gaa>Aaa	p.E525K	FNDC7_ENST00000271311.2_Missense_Mutation_p.E526K	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	526	Fibronectin type-III 6.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TGCTGTGGCCGAAACACAGGC	0.577000													24	52					0	0	1	0	0
SPINK4	27290	broad.mit.edu	37	9	33246683	33246683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33246683G>A	ENST00000379725.1	+	4	363	c.241G>A	c.(241-243)Ggg>Agg	p.G81R	SPINK4_ENST00000379721.3_Missense_Mutation_p.G58R|SPINK4_ENST00000379723.1_Missense_Mutation_p.G81R			O60575	ISK4_HUMAN	serine peptidase inhibitor, Kazal type 4	58	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			lung(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			CGGCACTGATGGGCTCACATA	0.567000													23	52					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7714547	7714547	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:7714547G>A	ENST00000507866.2	+	15	2065	c.1956G>A	c.(1954-1956)gaG>gaA	p.E652E	SORCS2_ENST00000329016.9_Silent_p.E480E	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	652						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						GCGGCGAGGAGGACTACAGCT	0.637000													11	22					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43813609	43813609	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43813609G>A	ENST00000382031.1	+	5	683	c.652G>A	c.(652-654)Gga>Aga	p.G218R	MAP1A_ENST00000300231.5_5'UTR|MAP1A_ENST00000399453.1_5'UTR			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	0						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GAGCCACCTGGGATTATCCAG	0.547000													16	81					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69969797	69969797	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:69969797C>T	ENST00000359154.2	+	18	1985	c.1884C>T	c.(1882-1884)ctC>ctT	p.L628L	WWP2_ENST00000356003.2_Silent_p.L628L|WWP2_ENST00000542271.1_Silent_p.L512L|WWP2_ENST00000568684.1_Silent_p.L189L|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000448661.1_Silent_p.L628L	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	628	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCTTCACCCTCCCTTTCTACA	0.532000													55	164					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28617391	28617391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28617391G>A	ENST00000395609.1	-	9	1519	c.761C>T	c.(760-762)cCc>cTc	p.P254L	SULT1A1_ENST00000569554.1_Missense_Mutation_p.P254L|SULT1A1_ENST00000314752.7_Missense_Mutation_p.P254L|SULT1A1_ENST00000350842.4_Missense_Mutation_p.P176L|SULT1A1_ENST00000395607.1_Missense_Mutation_p.P254L			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	254					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						CCTCATGAAGGGGGAGATGCT	0.607000													47	199					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99315203	99315203	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99315203C>T	ENST00000336374.2	-	5	380	c.378G>A	c.(376-378)tgG>tgA	p.W126*		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	126					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					GTATTCTCTTCCATTCTTCAT	0.383000													6	63					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28467325	28467325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28467325G>A	ENST00000261609.7	-	36	5609	c.5501C>T	c.(5500-5502)gCt>gTt	p.A1834V		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1834					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTGAGCAGAAGCATTCATATC	0.493000													16	57					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20024478	20024478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:20024478C>T	ENST00000400230.2	-	12	853	c.809G>A	c.(808-810)aGa>aAa	p.R270K	TPTE2_ENST00000255310.6_Missense_Mutation_p.R193K|TPTE2_ENST00000457266.2_Missense_Mutation_p.R159K|TPTE2_ENST00000390680.2_Missense_Mutation_p.R193K|TPTE2_ENST00000382977.4_Missense_Mutation_p.R270K|TPTE2_ENST00000382975.4_Missense_Mutation_p.R230K|TPTE2_ENST00000382978.1_Missense_Mutation_p.R230K|TPTE2_ENST00000400103.2_Missense_Mutation_p.R159K			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	270	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATCATAAGCTCTTTCACCTAA	0.294000													33	87					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33991943	33991943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33991943C>T	ENST00000389232.4	+	41	6358	c.6288C>T	c.(6286-6288)ttC>ttT	p.F2096F	RYR3_ENST00000415757.3_Silent_p.F2096F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2096	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTGCCGTTTCCTTTGCTATT	0.438000													7	29					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74876271	74876271	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74876271G>A	ENST00000331628.3	-	2	424	c.177C>T	c.(175-177)tcC>tcT	p.S59S	SYNDIG1L_ENST00000554823.1_Silent_p.S59S	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	59					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						CCAGCTGCAGGGACCCTGGGT	0.672000													8	28					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155486959	155486959	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155486959G>A	ENST00000302068.4	+	2	177		c.e2-1		FGB_ENST00000509493.1_Intron|FGB_ENST00000502545.1_Splice_Site	NM_005141.4	NP_005132.2	P02675	FIBB_HUMAN	fibrinogen beta chain						platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(22)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	ATTCCTTGTAGGGTTTCTTCA	0.463000													12	29					0	0	1	0	0
CH25H	9023	broad.mit.edu	37	10	90966300	90966300	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90966300G>A	ENST00000371852.2	-	1	771	c.750C>T	c.(748-750)ttC>ttT	p.F250F		NM_003956.3	NP_003947.1	O95992	CH25H_HUMAN	cholesterol 25-hydroxylase	250					bile acid biosynthetic process|fatty acid biosynthetic process|sterol biosynthetic process	cytosol|endoplasmic reticulum membrane|integral to membrane	cholesterol 25-hydroxylase activity|iron ion binding			kidney(1)|large_intestine(2)|lung(3)|stomach(1)	7		Colorectal(252;0.0161)		GBM - Glioblastoma multiforme(2;0.000133)		AGTACGGAGCGAAGTTGCAGT	0.582000													19	16					0	0	1	0	0
WNT5A	7474	broad.mit.edu	37	3	55504313	55504313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:55504313G>A	ENST00000474267.1	-	6	1471	c.950C>T	c.(949-951)tCg>tTg	p.S317L	WNT5A_ENST00000264634.4_Missense_Mutation_p.S317L|WNT5A_ENST00000497027.1_Missense_Mutation_p.S302L			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	317					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		CGTGCCCAGCGAGCCGGTGCT	0.627000													18	44					0	0	1	0	0
TANGO2	128989	broad.mit.edu	37	22	20049180	20049180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20049180C>T	ENST00000327374.4	+	7	757	c.579C>T	c.(577-579)ctC>ctT	p.L193L	TANGO2_ENST00000420290.2_Silent_p.L95L|TANGO2_ENST00000447208.2_Silent_p.L193L|TANGO2_ENST00000456048.1_Silent_p.L198L|TANGO2_ENST00000401886.1_Silent_p.L131L|TANGO2_ENST00000398042.2_Silent_p.L131L|TANGO2_ENST00000434570.2_Intron|TANGO2_ENST00000432883.1_Silent_p.L131L|TANGO2_ENST00000401833.1_Silent_p.L234L	NM_152906.4	NP_690870.3			transport and golgi organization 2 homolog (Drosophila)																		TCGCCAGCCTCCTGGATGTGC	0.642000													3	8					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161044144	161044144	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161044144C>T	ENST00000368012.3	-	6	1322	c.1020G>A	c.(1018-1020)ggG>ggA	p.G340G	PVRL4_ENST00000453926.2_Silent_p.G74G	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	340					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CCACCTGCTTCCCAGAGTCTT	0.612000													28	57					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74041116	74041116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74041116C>T	ENST00000409561.1	+	2	731	c.610C>T	c.(610-612)Ccc>Tcc	p.P204S		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	204										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						CCTGTCACTTCCCTGCCAGAT	0.473000													23	46					0	0	1	0	0
COPB1	1315	broad.mit.edu	37	11	14504625	14504625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:14504625G>A	ENST00000249923.3	-	8	1210	c.910C>T	c.(910-912)Cgc>Tgc	p.R304C	COPB1_ENST00000439561.2_Missense_Mutation_p.R304C	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	304					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						TCTATCAAGCGATCCAAAACT	0.308000													19	45					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367521	107367521	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107367521G>A	ENST00000542196.1	-	1	430	c.388C>T	c.(388-390)Ctg>Ttg	p.L130L		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						GGATATCTCAGAGGGTTGCAG	0.512000													9	139					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108385508	108385508	+	Silent	SNP	G	G	A	rs116742815	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108385508G>A	ENST00000265843.4	-	6	836	c.726C>T	c.(724-726)ttC>ttT	p.F242F	EXPH5_ENST00000428840.1_Silent_p.F166F|EXPH5_ENST00000524840.1_5'UTR|EXPH5_ENST00000443411.1_Silent_p.F54F|EXPH5_ENST00000525344.1_Silent_p.F235F	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	242					intracellular protein transport		Rab GTPase binding	p.F242F(1)		breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AAAAGTGACCGAACTGTGTTC	0.383000													50	115					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40399472	40399472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:40399472C>T	ENST00000338305.6	-	2	1923	c.1381G>A	c.(1381-1383)Gat>Aat	p.D461N		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	461	Fibronectin type-III.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGTACCTCATCGTCAGAGCAG	0.592000													21	50					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25326366	25326366	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25326366C>T	ENST00000546682.1	+	0	66				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TGGGATCCTCCTGGATGTAAG	0.488000													18	38					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157085	22157085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22157085G>A	ENST00000397126.4	-	4	899	c.751C>T	c.(751-753)Cat>Tat	p.H251Y	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTCCAGTATGAATTACCTTA	0.353000													24	47					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684591	100684591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100684591G>A	ENST00000306151.4	+	3	9958	c.9894G>A	c.(9892-9894)acG>acA	p.T3298T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3298	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTTCTGAAACGAGCACCCTTT	0.507000													252	514					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42122179	42122179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42122179C>T	ENST00000502486.1	-	5	1858	c.1279G>A	c.(1279-1281)Gag>Aag	p.E427K	BEND4_ENST00000504360.1_Missense_Mutation_p.E423K	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	427	BEN.									NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						TACTTAAGCTCATCGGTTGTG	0.468000													6	49					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54403940	54403940	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54403940G>A	ENST00000263431.3	+	14	1794	c.1512G>A	c.(1510-1512)gaG>gaA	p.E504E	PRKCG_ENST00000542049.1_Silent_p.E391E|PRKCG_ENST00000540413.1_Silent_p.E504E	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	504	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TGTGTAAGGAGAACGTCTTCC	0.587000													90	361					0	0	1	0	0
ACKR2	1238	broad.mit.edu	37	3	42906678	42906678	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42906678C>T	ENST00000422265.1	+	3	859	c.684C>T	c.(682-684)ttC>ttT	p.F228F	ACKR2_ENST00000471537.1_Intron|ACKR2_ENST00000442925.1_Silent_p.F228F|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Intron|ACKR2_ENST00000273145.2_Silent_p.F228F	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		CCATGATCTTCTTCTACTCCC	0.572000													84	164					0	0	1	0	0
USH1G	124590	broad.mit.edu	37	17	72916336	72916336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72916336G>A	ENST00000319642.1	-	2	777	c.595C>T	c.(595-597)Ctg>Ttg	p.L199L		NM_173477.2	NP_775748.2	Q495M9	USH1G_HUMAN	Usher syndrome 1G (autosomal recessive)	199					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton			HN1/USH1G(2)	endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(3)	14	all_lung(278;0.172)|Lung NSC(278;0.207)					GAGTACGGCAGGTGGCTGCCC	0.687000													16	43					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840247	27840247	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27840247G>A	ENST00000356790.2	+	3	1069	c.824G>A	c.(823-825)tGg>tAg	p.W275*		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	275	MAGE.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						CAATTCCTATGGGGCCCAAGA	0.468000													22	14					0	0	1	0	0
TCF4	6925	broad.mit.edu	37	18	52901800	52901800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52901800G>A	ENST00000354452.3	-	16	2076	c.1465C>T	c.(1465-1467)Cca>Tca	p.P489S	TCF4_ENST00000570177.2_Missense_Mutation_p.P359S|TCF4_ENST00000564403.2_Missense_Mutation_p.P495S|TCF4_ENST00000564999.1_Missense_Mutation_p.P489S|TCF4_ENST00000537856.3_Missense_Mutation_p.P359S|TCF4_ENST00000564228.1_Missense_Mutation_p.P418S|TCF4_ENST00000537578.1_Missense_Mutation_p.P465S|TCF4_ENST00000568673.1_Missense_Mutation_p.P465S|TCF4_ENST00000457482.3_Missense_Mutation_p.P329S|TCF4_ENST00000570287.2_Missense_Mutation_p.P329S|TCF4_ENST00000568740.1_Missense_Mutation_p.P464S|TCF4_ENST00000544241.2_Missense_Mutation_p.P418S|TCF4_ENST00000540999.1_Missense_Mutation_p.P465S|TCF4_ENST00000356073.4_Missense_Mutation_p.P489S|TCF4_ENST00000561831.3_Missense_Mutation_p.P329S|TCF4_ENST00000543082.1_Missense_Mutation_p.P447S|TCF4_ENST00000567880.1_Missense_Mutation_p.P429S|TCF4_ENST00000398339.1_Missense_Mutation_p.P591S|TCF4_ENST00000566286.1_Missense_Mutation_p.P486S|TCF4_ENST00000565018.2_Missense_Mutation_p.P489S|TCF4_ENST00000561992.1_Missense_Mutation_p.P359S|TCF4_ENST00000566279.1_Missense_Mutation_p.P429S	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	489					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TCCTGGGGTGGGTTCAGGTCA	0.562000											OREG0024990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	81					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7830111	7830111	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7830111C>T	ENST00000327325.5	+	3	289	c.171C>T	c.(169-171)tcC>tcT	p.S57S	CLEC4M_ENST00000248228.4_Silent_p.S57S|CLEC4M_ENST00000595496.1_Intron|CLEC4M_ENST00000596707.1_Intron|CLEC4M_ENST00000334806.5_Silent_p.S29S|CLEC4M_ENST00000596363.1_Silent_p.S29S|CLEC4M_ENST00000597522.1_Silent_p.S57S|CLEC4M_ENST00000357361.2_Silent_p.S57S|CLEC4M_ENST00000394122.2_Silent_p.S49S|CLEC4M_ENST00000359059.5_Intron	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	57					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						AACTCCTCTCCTTCATGCTCT	0.622000													34	101					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41009435	41009435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41009435C>T	ENST00000399564.4	-	32	3817	c.3367G>A	c.(3367-3369)Gac>Aac	p.D1123N	MROH2B_ENST00000506092.2_Missense_Mutation_p.D678N	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TCCAGTTTGTCTATTAAGGCT	0.507000													29	78					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061487	9061487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9061487C>T	ENST00000397910.4	-	3	26162	c.25959G>A	c.(25957-25959)gtG>gtA	p.V8653V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8655	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTTATAAATCACAGTCCCTA	0.448000													21	58					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544322	82544322	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82544322G>A	ENST00000423517.2	-	7	13317	c.12980C>T	c.(12979-12981)tCc>tTc	p.S4327F	PCLO_ENST00000333891.8_Missense_Mutation_p.S4327F|PCLO_ENST00000437081.1_Missense_Mutation_p.S1047F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4258					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATGACTAAAGGAAACATCTAG	0.423000													21	43					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142178189	142178189	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142178189C>T	ENST00000519811.1	+	13	1910	c.1840C>T	c.(1840-1842)Cat>Tat	p.H614Y	DENND3_ENST00000424248.1_Missense_Mutation_p.H482Y|DENND3_ENST00000262585.2_Missense_Mutation_p.H534Y			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	534										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GCAGGCATACCATGCCCACTT	0.532000													17	140					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34810239	34810239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34810239C>T	ENST00000338074.2	+	21	2721	c.2560C>T	c.(2560-2562)Cct>Tct	p.P854S	EPB41L1_ENST00000202028.5_Missense_Mutation_p.P752S|EPB41L1_ENST00000373941.1_Missense_Mutation_p.P853S|EPB41L1_ENST00000441639.1_Missense_Mutation_p.P752S|EPB41L1_ENST00000373946.3_Missense_Mutation_p.P674S|EPB41L1_ENST00000373950.2_Missense_Mutation_p.P745S	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	854	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					ACTGCAGCATCCTGATATGCT	0.522000													15	178					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220496784	220496784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220496784C>T	ENST00000358055.3	+	7	1418	c.906C>T	c.(904-906)gcC>gcT	p.A302A	SLC4A3_ENST00000273063.6_Silent_p.A329A|SLC4A3_ENST00000373760.2_Silent_p.A302A|SLC4A3_ENST00000497589.1_3'UTR|SLC4A3_ENST00000373762.3_Silent_p.A329A|SLC4A3_ENST00000317151.3_Silent_p.A302A			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	302					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGGCCTGGCCCCCATCCTTC	0.637000													18	52					0	0	1	0	0
FAHD2B	151313	broad.mit.edu	37	2	97757237	97757237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97757237G>A	ENST00000414820.1	-	3	477	c.207C>T	c.(205-207)ttC>ttT	p.F69F	FAHD2B_ENST00000440566.2_Silent_p.F69F|FAHD2B_ENST00000468548.1_Intron|FAHD2B_ENST00000272610.3_Silent_p.F69F			Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing 2B	69							hydrolase activity|metal ion binding			kidney(5)|large_intestine(2)|lung(3)|skin(2)	12						CCTGCTCTAGGAACTGCGTCA	0.607000													17	55					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31324936	31324936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31324936G>A	ENST00000269197.5	+	12	5124	c.5124G>A	c.(5122-5124)atG>atA	p.M1708I		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1708			M -> V (in dbSNP:rs7232237).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CACAGAACATGAAAGCTTCCA	0.552000													30	69					0	0	1	0	0
PACS2	23241	broad.mit.edu	37	14	105843141	105843141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105843141C>T	ENST00000447393.1	+	9	1013	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S	PACS2_ENST00000547217.1_Missense_Mutation_p.P250S|PACS2_ENST00000430725.2_Missense_Mutation_p.P205S|PACS2_ENST00000325438.8_Missense_Mutation_p.P280S|PACS2_ENST00000458164.2_Missense_Mutation_p.P280S	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	280					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GGAGCACATCCCCGAGGCAGA	0.677000													14	64					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33560122	33560122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:33560122C>T	ENST00000228567.3	-	3	975	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	SYT10_ENST00000535526.1_Missense_Mutation_p.E46K	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	227						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTGACATCTTCGTTTTGGTTG	0.383000													18	48					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26725472	26725472	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26725472C>T	ENST00000396005.3	-	5	857	c.548G>A	c.(547-549)tGg>tAg	p.W183*	SLC5A12_ENST00000280467.6_Nonsense_Mutation_p.W183*	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	183					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						TGCATCTGTCCACACCACTGC	0.433000													43	141					0	0	1	0	0
NRBF2	29982	broad.mit.edu	37	10	64893181	64893181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:64893181C>T	ENST00000435510.2	+	1	97	c.6C>T	c.(4-6)ttC>ttT	p.F2F	NRBF2_ENST00000277746.6_5'UTR			Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	0					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding			large_intestine(2)|lung(3)|skin(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CCTCCATGTTCCCCGGCGCCA	0.627000													10	16					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157805786	157805786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157805786C>T	ENST00000368174.4	-	3	311	c.215G>A	c.(214-216)gGa>gAa	p.G72E	CD5L_ENST00000484609.1_5'UTR	NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	72	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACTAGGGGTTCCGCTGGCAGC	0.542000													28	249					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70933619	70933619	+	Missense_Mutation	SNP	C	C	T	rs150844276	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70933619C>T	ENST00000334414.6	-	25	5728	c.5684G>A	c.(5683-5685)cGg>cAg	p.R1895Q	PTPRB_ENST00000550857.1_Missense_Mutation_p.R1587Q|PTPRB_ENST00000451516.2_Missense_Mutation_p.R1587Q|PTPRB_ENST00000550358.1_Missense_Mutation_p.R1807Q|PTPRB_ENST00000538708.1_Missense_Mutation_p.R1587Q|PTPRB_ENST00000261266.5_Missense_Mutation_p.R1677Q	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1677	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGAAGTTTTCCGGTTACTGTG	0.353000													22	85					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	18014197	18014197	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18014197C>T	ENST00000361221.3	+	27	3298	c.3139C>T	c.(3139-3141)Ctg>Ttg	p.L1047L	ARHGEF10L_ENST00000167825.4_Silent_p.L750L|ARHGEF10L_ENST00000452522.1_Silent_p.L1008L|ARHGEF10L_ENST00000375415.1_Silent_p.L1008L|ARHGEF10L_ENST00000434513.1_Silent_p.L1042L|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375408.3_Silent_p.L820L	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	1047					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CCTGGAGCATCTGCAAGAGAT	0.642000													11	49					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938588	2938588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2938588C>T	ENST00000378404.2	+	1	543	c.338C>T	c.(337-339)tCc>tTc	p.S113F		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	113						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		ACGGAGCCCTCCCTGAACCCC	0.602000													32	61					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86124923	86124923	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86124923C>T	ENST00000394518.2	+	7	3719	c.3624C>T	c.(3622-3624)gcC>gcT	p.A1208A	AKAP13_ENST00000361243.2_Silent_p.A1208A	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1208					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						ATGATGGGGCCCCAGCTGGTG	0.597000													15	63					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79387418	79387418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:79387418G>A	ENST00000370742.3	-	9	1200	c.1137C>T	c.(1135-1137)acC>acT	p.T379T		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	379	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TGCCATTCATGGTATCAGGTG	0.398000													30	80					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184210648	184210648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:184210648C>T	ENST00000403733.3	+	21	3443	c.3244C>T	c.(3244-3246)Cgc>Tgc	p.R1082C	WWC2_ENST00000504005.1_Missense_Mutation_p.R764C|WWC2_ENST00000448232.2_Missense_Mutation_p.R1106C|WWC2_ENST00000508747.1_Missense_Mutation_p.R210C|WWC2_ENST00000513834.1_Missense_Mutation_p.R1033C	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1082										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		CCGGCAGAGCCGCCTCAATGA	0.567000													8	32					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51960931	51960931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51960931G>A	ENST00000321424.3	-	2	583	c.517C>T	c.(517-519)Ctg>Ttg	p.L173L	SIGLEC8_ENST00000430817.1_Intron|SIGLEC8_ENST00000340550.5_Intron	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	173	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GAGCAGGTCAGGTTCCTGGAG	0.627000													30	101					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16373106	16373106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16373106C>T	ENST00000375679.4	+	4	417	c.306C>T	c.(304-306)gcC>gcT	p.A102A		NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCTGTGGCCCTCGTCTCTT	0.597000													20	66					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20249310	20249310	+	Missense_Mutation	SNP	C	C	T	rs3968186		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20249310C>T	ENST00000315957.4	+	1	910	c.829C>T	c.(829-831)Cat>Tat	p.H277Y		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GTCTGTGTTTCATACTGTAAT	0.388000													32	80					0	0	1	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342314	60342314	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60342314G>A	ENST00000581291.1	-	0	1839																				breast(2)|kidney(1)|lung(2)	5						ACGAGGAGGCGAAGCTTGCTT	0.468000													42	98					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9799447	9799447	+	Silent	SNP	C	C	T	rs141116659		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9799447C>T	ENST00000256460.3	-	11	1173	c.996G>A	c.(994-996)gcG>gcA	p.A332A	OGG1_ENST00000302036.7_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	332					cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		CCCCATGGCTCGCCGTCTGCC	0.652000													25	72					0	0	1	0	0
SNAPC2	6618	broad.mit.edu	37	19	7987638	7987638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7987638C>T	ENST00000221573.6	+	5	1045	c.994C>T	c.(994-996)Cct>Tct	p.P332S	SNAPC2_ENST00000597584.1_Missense_Mutation_p.P95S	NM_003083.3	NP_003074.1	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex, polypeptide 2, 45kDa	332					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6						GGCAGCCACCCCTGCCAGGTG	0.687000													39	103					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173916423	173916423	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:173916423G>A	ENST00000264111.6	+	31	3148	c.2961G>A	c.(2959-2961)cgG>cgA	p.R987R	RAPGEF4_ENST00000409036.1_Silent_p.R920R|RAPGEF4_ENST00000539331.1_Silent_p.R835R|RAPGEF4_ENST00000538974.1_Silent_p.R817R|RAPGEF4_ENST00000397087.3_Silent_p.R844R|RAPGEF4_ENST00000535187.1_Silent_p.R768R|RAPGEF4_ENST00000540783.1_Silent_p.R835R|RAPGEF4_ENST00000397081.3_Silent_p.R988R			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	988	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GTTATGTACGGCAATTAAATG	0.408000													24	60					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113196700	113196700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113196700C>T	ENST00000401783.2	-	30	5311	c.4975G>A	c.(4975-4977)Gat>Aat	p.D1659N	SVEP1_ENST00000374469.1_Missense_Mutation_p.D1636N	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1659	Sushi 5.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AAGCCTGGATCACAGAACAGA	0.502000													8	22					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784037	9784037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9784037C>T	ENST00000304374.2	+	1	780	c.384C>T	c.(382-384)atC>atT	p.I128I		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	128					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CTGCCTCCATCCTGAACCTGT	0.622000													6	40					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39871208	39871208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39871208G>A	ENST00000502986.2	+	10	1125	c.883G>A	c.(883-885)Ggc>Agc	p.G295S	IDO2_ENST00000389060.4_Missense_Mutation_p.G282S|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	282					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						TGAGTTCTTAGGCATTCGTCA	0.458000													8	42					0	0	1	0	0
WFDC2	10406	broad.mit.edu	37	20	44108342	44108342	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44108342G>A	ENST00000217425.5	+	3	310	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	WFDC2_ENST00000339946.3_Intron|WFDC2_ENST00000372676.3_Intron|WFDC2_ENST00000488143.1_3'UTR|WFDC2_ENST00000342873.3_5'UTR			Q14508	WFDC2_HUMAN	WAP four-disulfide core domain 2	0	WAP 2.				proteolysis|spermatogenesis	extracellular space	serine-type endopeptidase inhibitor activity			lung(1)	1		Myeloproliferative disorder(115;0.0122)				cctaggccacgaaggcccact	0.542000													39	65					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94056942	94056942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94056942C>T	ENST00000297268.6	+	49	3742	c.3271C>T	c.(3271-3273)Ccc>Tcc	p.P1091S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	1091					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTTGCAGGGCCCCCCTGGTCC	0.532000										HNSCC(75;0.22)			42	109					0	0	1	0	0
BAAT	570	broad.mit.edu	37	9	104125158	104125158	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104125158T>A	ENST00000259407.2	-	4	917	c.809A>T	c.(808-810)tAt>tTt	p.Y270F	BAAT_ENST00000395051.3_Missense_Mutation_p.Y270F	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	270					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	CTGACCATGATATACCTGTGG	0.438000													29	59					0	0	1	0	0
DMRTA1	63951	broad.mit.edu	37	9	22451350	22451350	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:22451350C>T	ENST00000325870.1	+	2	1180	c.955C>T	c.(955-957)Ctt>Ttt	p.L319F		NM_022160.2	NP_071443.2	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	319					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		CAAGGCAAGCCTTCCGACAGT	0.478000													6	49					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50701195	50701195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50701195G>A	ENST00000355832.5	-	8	1867	c.1789C>T	c.(1789-1791)Cta>Tta	p.L597L	ERCC6_ENST00000542458.1_Intron	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	597	Helicase ATP-binding.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GTTTCATGTAGAATTGCCACT	0.413000								Direct reversal of damage;Nucleotide excision repair (NER)					12	42					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75679468	75679468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75679468G>A	ENST00000370855.5	-	22	1997	c.1884C>T	c.(1882-1884)gcC>gcT	p.A628A	SLC44A5_ENST00000535611.1_Silent_p.A498A|SLC44A5_ENST00000370859.3_Silent_p.A628A	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	628						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						AGAATAGGAAGGCCAGAACAC	0.368000													40	92					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16612290	16612290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:16612290G>A	ENST00000443444.2	+	5	1059	c.919G>A	c.(919-921)Gaa>Aaa	p.E307K	CCDC144A_ENST00000340621.5_Missense_Mutation_p.E306K|CCDC144A_ENST00000360524.8_Missense_Mutation_p.E307K|CCDC144A_ENST00000399273.1_Missense_Mutation_p.E307K|RP11-219A15.1_ENST00000448331.3_Missense_Mutation_p.E307K|CCDC144A_ENST00000456009.1_Intron			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	307																	TGAAATTTATGAAAAATACAA	0.338000													22	38					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71762184	71762184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71762184C>T	ENST00000258104.3	+	14	1595	c.1318C>T	c.(1318-1320)Cct>Tct	p.P440S	DYSF_ENST00000394120.2_Missense_Mutation_p.P441S|DYSF_ENST00000409744.1_Missense_Mutation_p.P441S|DYSF_ENST00000410020.3_Missense_Mutation_p.P472S|DYSF_ENST00000413539.2_Missense_Mutation_p.P471S|DYSF_ENST00000429174.2_Missense_Mutation_p.P440S|DYSF_ENST00000409366.1_Missense_Mutation_p.P441S|DYSF_ENST00000409582.3_Missense_Mutation_p.P471S|DYSF_ENST00000409762.1_Missense_Mutation_p.P471S|DYSF_ENST00000409651.1_Missense_Mutation_p.P472S|DYSF_ENST00000410041.1_Missense_Mutation_p.P472S	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	440	C2 3.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GACGGCCAACCCTCAGTGGAA	0.627000													15	62					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85935348	85935348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:85935348G>A	ENST00000383699.3	+	5	1027	c.400G>A	c.(400-402)Gaa>Aaa	p.E134K	CADM2_ENST00000407528.2_Missense_Mutation_p.E125K|CADM2_ENST00000405615.2_Missense_Mutation_p.E127K	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	125	Ig-like C2-type 1.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AGGTGTTCCTGAAAAGCCTCA	0.393000													17	58					0	0	1	0	0
MARK4	57787	broad.mit.edu	37	19	45801408	45801408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45801408C>T	ENST00000300843.4	+	16	2182	c.1885C>T	c.(1885-1887)Ctc>Ttc	p.L629F	MARK4_ENST00000262891.4_Intron	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	629					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CAGGGTTACCCTCGATCCCTC	0.597000													11	45					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121439	50121439	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50121439C>T	ENST00000374160.3	-	1	838	c.762G>A	c.(760-762)tgG>tgA	p.W254*	RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Nonsense_Mutation_p.W254*|WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	254						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CAAGTCACCTCCAGTCTTCCC	0.547000													57	150					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1457134	1457134	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1457134G>A	ENST00000535453.1	+	8	2812	c.1099G>A	c.(1099-1101)Gag>Aag	p.E367K	APC2_ENST00000233607.2_Missense_Mutation_p.E367K|APC2_ENST00000238483.4_Intron			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	367					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGCGCAAGGAGATGCGCGT	0.731000													4	4					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49005761	49005761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:49005761C>T	ENST00000226432.4	+	7	995	c.812C>T	c.(811-813)tCa>tTa	p.S271L	CWH43_ENST00000513409.1_Missense_Mutation_p.S244L	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	271					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						GGAACAGCTTCAGCTGCGGGG	0.502000													42	86					0	0	1	0	0
PRPF31	26121	broad.mit.edu	37	19	54625919	54625919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54625919C>T	ENST00000321030.4	+	5	715	c.366C>T	c.(364-366)ttC>ttT	p.F122F	PRPF31_ENST00000391755.1_Silent_p.F122F|PRPF31_ENST00000419967.1_Silent_p.F122F|PRPF31_ENST00000498612.1_3'UTR|AC012314.8_ENST00000452097.1_RNA	NM_015629.3	NP_056444.3	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31	122					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)|urinary_tract(3)	12	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAAAGAGATTCCCTGAACTGG	0.537000													144	95					0	0	1	0	0
TMEM59L	25789	broad.mit.edu	37	19	18731332	18731332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18731332C>T	ENST00000600490.1	+	9	1200	c.1015C>T	c.(1015-1017)Ctg>Ttg	p.L339L	TMEM59L_ENST00000262817.3_Silent_p.L339L			Q9UK28	TM59L_HUMAN	transmembrane protein 59-like	339						Golgi membrane|integral to membrane|membrane fraction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(2)	13						GAAGCTGGACCTGACCAAGCT	0.662000													18	51					0	0	1	0	0
TNFRSF10C	8794	broad.mit.edu	37	8	22974279	22974279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22974279C>T	ENST00000356864.3	+	5	1047	c.515C>T	c.(514-516)cCg>cTg	p.P172L	TNFRSF10C_ENST00000540813.1_Missense_Mutation_p.P70L	NM_003841.3	NP_003832.2	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	172					apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(6)|lung(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		AACACCAGCCCGGGGACTCCT	0.562000													14	143					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59113078	59113078	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:59113078G>A	ENST00000395153.3	+	4	1773	c.1626G>A	c.(1624-1626)gtG>gtA	p.V542V	DACT1_ENST00000335867.4_Silent_p.V579V|DACT1_ENST00000556859.1_Silent_p.V298V|DACT1_ENST00000395151.3_Silent_p.V298V|DACT1_ENST00000541264.2_Silent_p.V298V	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	579					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						TGGGCGTCGTGAAGAACTCCA	0.662000													9	26					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166408671	166408671	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:166408671A>C	ENST00000402744.4	+	6	1335	c.1055A>C	c.(1054-1056)gAg>gCg	p.E352A		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	352					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCACCTGAAGAGACTCTGAAG	0.453000													20	61					0	0	1	0	0
KAZN	23254	broad.mit.edu	37	1	14925592	14925592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:14925592C>T	ENST00000376030.2	+	1	393	c.99C>T	c.(97-99)acC>acT	p.T33T	KAZN_ENST00000503743.1_Silent_p.T33T|KAZN_ENST00000422387.2_Silent_p.T33T	NM_201628.2	NP_963922.2	Q674X7	KAZRN_HUMAN	kazrin, periplakin interacting protein	33					keratinization	cornified envelope|cytoplasm|desmosome|nucleus				central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(1)|prostate(2)	25						TCACGGCCACCAACCGGAGAC	0.731000													12	40					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20168604	20168604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20168604G>A	ENST00000245957.5	+	14	1492	c.1416G>A	c.(1414-1416)ttG>ttA	p.L472L	C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377309.2_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	472										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		CCACTCTCTTGGATACTCCTG	0.393000													17	91					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14851538	14851538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14851538C>T	ENST00000358984.4	+	36	3418	c.3238C>T	c.(3238-3240)Ctc>Ttc	p.L1080F		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1165										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TGAAAATGATCTCTTTCATGA	0.308000													9	13					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27800631	27800631	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27800631C>T	ENST00000408964.2	+	1	1243	c.1192C>T	c.(1192-1194)Caa>Taa	p.Q398*		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	398										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					GTTAGGACATCAAGTCCCAGA	0.438000													37	71					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585704	82585704	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82585704G>A	ENST00000423517.2	-	5	4902	c.4565C>T	c.(4564-4566)tCa>tTa	p.S1522L	PCLO_ENST00000333891.8_Missense_Mutation_p.S1522L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1453					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGAACAGGTGAGTTTTCACT	0.423000													18	31					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238270463	238270463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238270463G>A	ENST00000295550.4	-	15	6527	c.6075C>T	c.(6073-6075)gcC>gcT	p.A2025A	COL6A3_ENST00000409809.1_Silent_p.A1819A|COL6A3_ENST00000472056.1_Silent_p.A1418A|COL6A3_ENST00000346358.4_Silent_p.A1825A|COL6A3_ENST00000353578.4_Silent_p.A1819A|COL6A3_ENST00000347401.3_Silent_p.A1824A	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2025	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AAGCTTTCTCGGCAATGTTGT	0.522000													23	84					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20652291	20652291	+	Silent	SNP	C	C	T	rs143680068	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20652291C>T	ENST00000525748.1	+	10	1827	c.1554C>T	c.(1552-1554)ttC>ttT	p.F518F	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	518					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	TTGCCGGCTTCGTCATCTTCT	0.493000													35	100					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841872	13841872	+	Missense_Mutation	SNP	G	G	A	rs142155986	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13841872G>A	ENST00000265104.4	-	33	5517	c.5413C>T	c.(5413-5415)Cgc>Tgc	p.R1805C		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1805	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCTGCCTGGCGAATCACAAGA	0.408000									Kartagener syndrome				37	92					0	0	1	0	0
CHMP1B	57132	broad.mit.edu	37	18	11851674	11851674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:11851674C>T	ENST00000526991.2	+	1	280	c.164C>T	c.(163-165)gCc>gTc	p.A55V	RP11-78A19.3_ENST00000586474.1_RNA|GNAL_ENST00000535121.1_Intron|GNAL_ENST00000423027.3_Intron|GNAL_ENST00000334049.6_Intron|GNAL_ENST00000269162.5_Intron	NM_020412.4	NP_065145.2	Q7LBR1	CHM1B_HUMAN	charged multivesicular body protein 1B	55					cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding			endometrium(1)|lung(1)|urinary_tract(1)	3						GCCGAAAATGCCATCCGCCAG	0.527000													15	42					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43099815	43099815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43099815C>T	ENST00000230419.4	+	6	1095	c.874C>T	c.(874-876)Cgg>Tgg	p.R292W	PTK7_ENST00000481273.1_Missense_Mutation_p.R300W|PTK7_ENST00000345201.2_Missense_Mutation_p.R292W|PTK7_ENST00000471863.1_Missense_Mutation_p.R292W|PTK7_ENST00000349241.2_Missense_Mutation_p.R292W|PTK7_ENST00000352931.2_Missense_Mutation_p.R292W	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	292	Ig-like C2-type 3.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.R292W(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GACCCAGGTCCGGCCACGCAA	0.617000													26	56					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11596500	11596500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11596500C>T	ENST00000304391.6	+	5	713	c.595C>T	c.(595-597)Cgc>Tgc	p.R199C	PTCHD2_ENST00000389575.3_Silent_p.I1312I|PTCHD2_ENST00000294484.6_Silent_p.I1312I			Q9P2K9	PTHD2_HUMAN	patched domain containing 2	0					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCTGCATCATCGCCCCATTTG	0.637000													27	69					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178769882	178769882	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:178769882G>A	ENST00000286063.5	-	3	1421	c.1104C>T	c.(1102-1104)atC>atT	p.I368I	PDE11A_ENST00000358450.4_Silent_p.I118I|PDE11A_ENST00000497003.1_5'UTR|PDE11A_ENST00000449286.2_Silent_p.I10I|PDE11A_ENST00000409504.1_Silent_p.I10I	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	368	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TAGATATGGCGATTCCACAAA	0.363000									Primary Pigmented Nodular Adrenocortical Disease, Familial				12	40					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15651288	15651288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15651288C>T	ENST00000269703.2	+	8	898	c.699C>T	c.(697-699)atC>atT	p.I233I	CYP4F22_ENST00000601005.2_Silent_p.I233I	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	233						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	p.I233I(1)		endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						TCTCCGCTATCATTGAACTGA	0.557000													28	75					0	0	1	0	0
PRRG1	5638	broad.mit.edu	37	X	37312709	37312709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37312709C>T	ENST00000542554.1	+	5	764	c.492C>T	c.(490-492)tcC>tcT	p.S164S	PRRG1_ENST00000543642.1_Silent_p.S164S|TM4SF2_ENST00000465127.1_Intron|PRRG1_ENST00000378628.4_Silent_p.S164S|PRRG1_ENST00000449135.2_Silent_p.S164S|PRRG1_ENST00000491253.1_3'UTR	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	164						extracellular region|integral to plasma membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						CTCGCCTGTCCAATTGTGATC	0.542000													30	27					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995791	19995791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:19995791G>A	ENST00000391403.2	-	1	2087	c.1984C>T	c.(1984-1986)Cct>Tct	p.P662S		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	662	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGAGGTGGAGGAACAAAGCCA	0.473000													96	233					0	0	1	0	0
CDC25A	993	broad.mit.edu	37	3	48209415	48209415	+	Missense_Mutation	SNP	G	G	A	rs141219026	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48209415G>A	ENST00000302506.3	-	10	1358	c.950C>T	c.(949-951)tCc>tTc	p.S317F	CDC25A_ENST00000459900.1_5'UTR|CDC25A_ENST00000351231.3_Missense_Mutation_p.S277F	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	317					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		AGATGCCAGGGATAAAGACTG	0.443000													15	44					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124624623	124624623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124624623G>A	ENST00000278927.5	-	5	773	c.644C>T	c.(643-645)tCg>tTg	p.S215L	ESAM_ENST00000442070.2_Missense_Mutation_p.S36L	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	215	Ig-like C2-type.				blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		CATGGAAGACGAAAGGTTGGT	0.483000													51	131					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22163861	22163861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:22163861C>T	ENST00000389397.4	+	32	3479	c.617C>T	c.(616-618)gCt>gTt	p.A206V	VWA3A_ENST00000389398.5_Missense_Mutation_p.A1104V|VWA3A_ENST00000563755.1_Missense_Mutation_p.A206V			A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1104						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		AGAAAGCTGGCTTCCTTCACC	0.567000													7	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064299	9064299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9064299G>A	ENST00000397910.4	-	3	23350	c.23147C>T	c.(23146-23148)cCt>cTt	p.P7716L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7718	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAAGTCACAGGAAGGGGAGA	0.547000													14	77					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57745960	57745960	+	Missense_Mutation	SNP	G	G	A	rs149480547		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57745960G>A	ENST00000281282.5	+	7	2212	c.2134G>A	c.(2134-2136)Gat>Aat	p.D712N		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	712						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGAAATGCACGATGAACTGGA	0.562000													10	34					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24559266	24559266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24559266G>A	ENST00000535378.1	-	18	3324	c.2682C>T	c.(2680-2682)ttC>ttT	p.F894F	KIAA0319_ENST00000378214.3_Silent_p.F903F|KIAA0319_ENST00000430948.2_Silent_p.F858F|KIAA0319_ENST00000543707.1_Silent_p.F903F|KIAA0319_ENST00000537886.1_Silent_p.F903F	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	903					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						TCAAGACCTTGAAAAGCAAGA	0.453000													7	18					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4928848	4928848	+	Silent	SNP	G	G	A	rs146129201		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4928848G>A	ENST00000359350.4	+	1	249	c.249G>A	c.(247-249)agG>agA	p.R83R	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATGTTGAGGGTCTTCTTGT	0.468000													35	125					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73749129	73749129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73749129C>T	ENST00000276033.5	+	5	1640	c.1474C>T	c.(1474-1476)Ctt>Ttt	p.L492F	SLC16A2_ENST00000587091.1_Missense_Mutation_p.L418F			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	418						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	CGTCGTCTGTCTTTTCCTGGG	0.577000													15	11					0	0	1	0	0
STRC	161497	broad.mit.edu	37	15	43893672	43893672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43893672C>T	ENST00000450892.2	-	24	4700	c.4623G>A	c.(4621-4623)cgG>cgA	p.R1541R	STRC_ENST00000541030.1_Silent_p.R768R	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1541					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		CCTGTAGTTCCCGATCTCCTA	0.552000													37	83					0	0	1	0	0
CDC123	8872	broad.mit.edu	37	10	12279228	12279228	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:12279228C>T	ENST00000281141.4	+	9	931	c.651C>T	c.(649-651)ttC>ttT	p.F217F	CDC123_ENST00000378900.2_Intron|CDC123_ENST00000455773.3_3'UTR	NM_006023.2	NP_006014.2	O75794	CD123_HUMAN	cell division cycle 123	217					cell cycle arrest|cell division|positive regulation of cell proliferation|regulation of mitotic cell cycle	cytoplasm		p.F217L(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12						AAGACTTTTTCAAGAAACACA	0.289000													28	67					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492823	21492823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:21492823C>T	ENST00000377142.4	-	2	916	c.560G>A	c.(559-561)cGg>cAg	p.R187Q	NKX2-2-AS1_ENST00000549659.1_RNA	NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	187					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						TTTCTCGGCCCGGGCGCGCTT	0.677000													15	38					0	0	1	0	0
TEDDM1	127670	broad.mit.edu	37	1	182368876	182368876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:182368876G>A	ENST00000367565.1	-	1	875	c.745C>T	c.(745-747)Ctc>Ttc	p.L249F		NM_172000.3	NP_741997.3	Q5T9Z0	TEDM1_HUMAN	transmembrane epididymal protein 1	249						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)	7						AACTTGTAGAGGGGTCCTGGA	0.517000													32	55					0	0	1	0	0
EEF1A2	1917	broad.mit.edu	37	20	62126323	62126323	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62126323C>T	ENST00000217182.3	-	4	621	c.456G>A	c.(454-456)gtG>gtA	p.V152V	EEF1A2_ENST00000298049.7_Silent_p.V152V	NM_001958.3	NP_001949.1	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha 2	152						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(14)|stomach(1)	20	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CCATTTTGTTCACGCCCACGA	0.607000													13	96					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120192591	120192591	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:120192591C>T	ENST00000450251.1	+	12	2120	c.1576C>T	c.(1576-1578)Cga>Tga	p.R526*	USP53_ENST00000274030.6_Nonsense_Mutation_p.R526*			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	526					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						ACCTCAGAGTCGAGCTTCTGC	0.398000													31	71					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475757	140475757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140475757C>T	ENST00000194155.4	+	1	1531	c.1383C>T	c.(1381-1383)ttC>ttT	p.F461F		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		461	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.632000													54	207					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173961099	173961099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:173961099C>T	ENST00000506823.1	+	13	2311	c.1654C>T	c.(1654-1656)Cat>Tat	p.H552Y	GALNTL6_ENST00000508122.1_Missense_Mutation_p.H535Y	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	552	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						AACATTATTCCATCCTGTGAG	0.428000													21	64					0	0	1	0	0
IP6K3	117283	broad.mit.edu	37	6	33693290	33693290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33693290C>T	ENST00000451316.1	-	6	1228	c.693G>A	c.(691-693)aaG>aaA	p.K231K	IP6K3_ENST00000293756.4_Silent_p.K231K	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	231					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						GGCGGGCCTTCTTCTCCTCCG	0.607000													13	36					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179408964	179408964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179408964C>T	ENST00000589042.1	-	345	96216	c.95992G>A	c.(95992-95994)Gaa>Aaa	p.E31998K	TTN_ENST00000342992.6_Missense_Mutation_p.E29430K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E22933K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E23125K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E23058K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E30357K|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30357	Ig-like 142.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAATTGATTCGCTGTATTCG	0.383000													21	52					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435398	158435398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158435398G>A	ENST00000289451.2	+	1	127	c.47G>A	c.(46-48)gGc>gAc	p.G16D		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					GTCGTCCTCGGCTTCTCATCC	0.507000													12	58					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94707034	94707034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94707034C>T	ENST00000304338.3	+	9	1032	c.878C>T	c.(877-879)cCc>cTc	p.P293L		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	293						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						ACTATACTTCCCTTAGTGAAA	0.308000													10	33					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56246224	56246224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56246224G>A	ENST00000361673.3	-	4	1997	c.1784C>T	c.(1783-1785)tCc>tTc	p.S595F	ALPK2_ENST00000587399.1_5'UTR	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	595							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						ATCAGCATGGGAACTCCGACC	0.488000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	85					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16000345	16000345	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16000345G>T	ENST00000221700.5	-	7	901	c.806C>A	c.(805-807)gCc>gAc	p.A269D	CYP4F2_ENST00000592328.1_Missense_Mutation_p.A269D|CYP4F2_ENST00000011989.7_Missense_Mutation_p.A120D	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	269			A -> D (in dbSNP:rs1805040).		leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding	p.A269V(1)		NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CTGGATGACGGCATCTGTGAA	0.557000													16	188					1.10923e-09	1.11355e-09	1	1	0
DOT1L	84444	broad.mit.edu	37	19	2211188	2211188	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2211188C>T	ENST00000398665.3	+	15	1478	c.1442C>T	c.(1441-1443)cCg>cTg	p.P481L		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	481						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCCCACCCCGCCCGCGCTG	0.672000													29	67					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67066476	67066476	+	Silent	SNP	G	G	A	rs147341587		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:67066476G>A	ENST00000315962.4	+	9	1804	c.1431G>A	c.(1429-1431)tcG>tcA	p.S477S	TRIM55_ENST00000350034.4_Intron|TRIM55_ENST00000276573.7_Silent_p.S477S|TRIM55_ENST00000353317.5_Intron	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	477						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CTGAGGATTCGAATGTACGGA	0.567000													29	42					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180056987	180056987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180056987C>T	ENST00000261937.6	-	5	710	c.632G>A	c.(631-633)gGa>gAa	p.G211E	FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Missense_Mutation_p.G211E|FLT4_ENST00000502649.1_Missense_Mutation_p.G211E	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	211	Ig-like C2-type 2.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GTCCTGGTCTCCCCAGGTGGT	0.642000													25	36					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11642314	11642314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11642314G>A	ENST00000262442.3	+	29	6000	c.5932G>A	c.(5932-5934)Ggc>Agc	p.G1978S	DNAH9_ENST00000454412.2_Missense_Mutation_p.G1978S	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1978	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGGCTATGCTGGCCGCACAGA	0.488000													11	37					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8521544	8521544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8521544G>A	ENST00000381196.4	-	17	1237	c.694C>T	c.(694-696)Cgc>Tgc	p.R232C	PTPRD_ENST00000358503.5_Missense_Mutation_p.R219C|PTPRD_ENST00000397611.3_Missense_Mutation_p.R229C|PTPRD_ENST00000356435.5_Missense_Mutation_p.R232C|PTPRD_ENST00000397617.3_Missense_Mutation_p.R222C|PTPRD_ENST00000397606.3_Missense_Mutation_p.R222C|PTPRD_ENST00000540109.1_Missense_Mutation_p.R232C|PTPRD_ENST00000360074.4_Missense_Mutation_p.R219C|PTPRD_ENST00000486161.1_Missense_Mutation_p.R232C|PTPRD_ENST00000537002.1_Missense_Mutation_p.R229C|PTPRD_ENST00000355233.5_Missense_Mutation_p.R232C	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	232					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.R232C(2)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGGACACGGCGAACTGGAACA	0.448000										TSP Lung(15;0.13)			29	71					0	0	1	0	0
ZNF724P	440519	broad.mit.edu	37	19	23405633	23405633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23405633G>A	ENST00000418100.1	-	4	1531	c.1414C>T	c.(1414-1416)Cat>Tat	p.H472Y																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						TCTCCAGTATGAATTATCCTA	0.368000													28	84					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28575418	28575418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:28575418C>T	ENST00000220562.4	+	3	2744	c.1842C>T	c.(1840-1842)ttC>ttT	p.F614F	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Silent_p.F230F	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	614						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TCCATCTTTTCCCCCACACTC	0.572000													22	116					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551633	35551633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35551633G>A	ENST00000262626.2	+	9	1548	c.723G>A	c.(721-723)ggG>ggA	p.G241G	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Silent_p.G83G|HPN_ENST00000392226.1_Silent_p.G241G	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	241	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	TCTACCACGGGGGCTATCTTC	0.642000													24	76					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719089	140719089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140719089G>A	ENST00000394576.2	+	1	551	c.551G>A	c.(550-552)aGg>aAg	p.R184K	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGTGCGAAGGGGAGCTGAT	0.562000													33	92					0	0	1	0	0
SKAP2	8935	broad.mit.edu	37	7	26766566	26766566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:26766566G>A	ENST00000345317.2	-	7	842	c.529C>T	c.(529-531)Cta>Tta	p.L177L	SKAP2_ENST00000489977.1_5'UTR|SKAP2_ENST00000539623.1_Silent_p.L5L	NM_003930.3	NP_003921.2	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	177	PH.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						TCCTTTCTTAGAGTGTTATTC	0.323000													5	59					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37164388	37164388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:37164388G>A	ENST00000274258.7	-	37	7802	c.4215C>T	c.(4213-4215)ttC>ttT	p.F1405F	C5orf42_ENST00000425232.2_Silent_p.F2525F|C5orf42_ENST00000508244.1_Silent_p.F2525F			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2525								p.F1405F(1)|p.F2525F(1)		breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			AAGGAACGTCGAAGTCATCCA	0.318000													34	69					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108278674	108278674	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108278674G>A	ENST00000295746.8	-	16	2019	c.1943C>T	c.(1942-1944)gCt>gTt	p.A648V	KIAA1524_ENST00000491772.1_Missense_Mutation_p.A489V	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	648						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AAGGGCTAGAGCTTTTGTTTC	0.358000													15	46					0	0	1	0	0
CACNG1	786	broad.mit.edu	37	17	65040977	65040977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:65040977G>A	ENST00000226021.3	+	1	272	c.201G>A	c.(199-201)aaG>aaA	p.K67K		NM_000727.3	NP_000718.1	Q06432	CCG1_HUMAN	calcium channel, voltage-dependent, gamma subunit 1	67					muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(1)|large_intestine(2)|lung(2)|prostate(1)|skin(2)	8	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	ACGACAGCAAGACCTGCGGGC	0.652000													10	26					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932427	83932427	+	Missense_Mutation	SNP	C	C	T	rs149687703		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83932427C>T	ENST00000345382.2	-	4	1661	c.1576G>A	c.(1576-1578)Gaa>Aaa	p.E526K	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.E519K	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	526					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						AATGGCATTTCGTTTGAAATG	0.488000													35	124					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306689	41306689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:41306689C>T	ENST00000373198.3	-	7	1205	c.970G>A	c.(970-972)Gaa>Aaa	p.E324K	PTPRT_ENST00000373193.3_Missense_Mutation_p.E324K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E324K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E324K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E324K|PTPRT_ENST00000373187.1_Missense_Mutation_p.E324K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E324K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	324	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TATTCCACTTCCTTCAGGATG	0.567000													30	68					0	0	1	0	0
IL2	3558	broad.mit.edu	37	4	123374954	123374954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123374954C>T	ENST00000226730.4	-	3	546	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K		NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2	88					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		TTTAGCACTTCCTCCAGAGGT	0.368000			T	TNFRSF17	intestinal T-cell lymphoma								39	112					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017688	1017688	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1017688C>T	ENST00000421673.2	-	31	5163	c.5113G>A	c.(5113-5115)Gaa>Aaa	p.E1705K		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1705	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAGGTGGCTTCAGCATGGTGT	0.557000													79	620					0	0	1	0	0
MIR320A	407037	broad.mit.edu	37	8	22102552	22102552	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22102552G>A	ENST00000385302.1	-	0	4					NR_029714.1																						GGAGGGGAGCGAAGCGCCGCC	0.642000													21	72					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1271266	1271266	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1271266G>A	ENST00000310581.5	-	8	2493	c.2436C>T	c.(2434-2436)ttC>ttT	p.F812F	TERT_ENST00000296820.5_Intron|TERT_ENST00000508104.2_Intron|TERT_ENST00000334602.6_Silent_p.F812F	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	812	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGTGGCACATGAAGCGTAGGA	0.652000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				6	52					0	0	1	0	0
SCIN	85477	broad.mit.edu	37	7	12691524	12691524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:12691524C>T	ENST00000297029.5	+	15	2119	c.2018C>T	c.(2017-2019)tCt>tTt	p.S673F	SCIN_ENST00000445618.2_Missense_Mutation_p.S426F|SCIN_ENST00000519209.1_Missense_Mutation_p.S426F	NM_001112706.2	NP_001106177.1	Q9Y6U3	ADSV_HUMAN	scinderin	673	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	17				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TCTCTGAAGTCTGGTAAGCTC	0.368000													4	6					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38877381	38877381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38877381G>A	ENST00000359357.3	+	63	9204	c.8950G>A	c.(8950-8952)Gag>Aag	p.E2984K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E3201K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E2948K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTGGCCAAGGGAGGCTCTGAT	0.448000													36	93					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955761	18955761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18955761G>A	ENST00000302797.3	-	1	795	c.571C>T	c.(571-573)Ctc>Ttc	p.L191F	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	191					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GACCCACAGAGAACCACACAT	0.507000													21	52					0	0	1	0	0
ERCC3	2071	broad.mit.edu	37	2	128029016	128029016	+	Missense_Mutation	SNP	G	G	A	rs139049289		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128029016G>A	ENST00000493187.2	-	12	2112	c.1649C>T	c.(1648-1650)tCg>tTg	p.S550L	ERCC3_ENST00000285398.2_Missense_Mutation_p.S614L			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	614	Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CAGATCAAACGAAGTGTCACC	0.423000			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				55	119					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160766091	160766091	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160766091C>T	ENST00000263285.5	+	1	144	c.114C>T	c.(112-114)ttC>ttT	p.F38F	LY9_ENST00000471816.1_3'UTR|LY9_ENST00000368039.2_Silent_p.F38F|LY9_ENST00000341032.4_Silent_p.F38F|LY9_ENST00000368040.1_5'UTR|LY9_ENST00000368041.2_5'UTR	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	38					cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTCTCCTCTTCCTGCTCATGG	0.493000													37	183					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56520206	56520206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56520206G>A	ENST00000390649.3	+	3	495	c.495G>A	c.(493-495)aaG>aaA	p.K165K		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	165						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GACCAAGCAAGGAAAAAGTGC	0.468000													4	18					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34129178	34129178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34129178C>T	ENST00000389232.4	+	88	11710	c.11640C>T	c.(11638-11640)tcC>tcT	p.S3880S	RYR3_ENST00000415757.3_Silent_p.S3875S	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3880					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGCTTCTGTCCCTCCTGGAAG	0.483000													11	15					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18391067	18391067	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:18391067G>A	ENST00000338745.6	-	11	3621	c.1887C>T	c.(1885-1887)ccC>ccT	p.P629P	SATB1_ENST00000454909.2_Silent_p.P629P|SATB1_ENST00000417717.2_Silent_p.P661P|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	629					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						AGGCCACCGTGGGTTGCCGTG	0.607000													20	44					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32014099	32014099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32014099C>T	ENST00000375244.3	-	31	10660	c.10459G>A	c.(10459-10461)Gac>Aac	p.D3487N	TNXB_ENST00000375247.2_Missense_Mutation_p.D3485N			P22105	TENX_HUMAN	tenascin XB	3532					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GGCTGCCCGTCCGTGTCCCTG	0.632000													10	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070533	9070533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9070533G>A	ENST00000397910.4	-	3	17116	c.16913C>T	c.(16912-16914)tCc>tTc	p.S5638F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5640	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGATGTCATGGAAGGTGACAT	0.527000													15	16					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6091063	6091063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6091063G>A	ENST00000217289.4	-	5	1416	c.628C>T	c.(628-630)Cct>Tct	p.P210S	FERMT1_ENST00000536936.1_Intron	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	210	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TCCGTCAAAGGGCTGTCACTG	0.498000													43	81					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34826110	34826110	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34826110C>T	ENST00000192788.5	+	14	2148	c.1977C>T	c.(1975-1977)agC>agT	p.S659S	UHRF1BP1_ENST00000452449.2_Silent_p.S659S	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	659										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						GTGGCTTTAGCCTTCTGCACA	0.493000													48	123					0	0	1	0	0
B3GNTL1	146712	broad.mit.edu	37	17	80918997	80918997	+	Missense_Mutation	SNP	G	G	A	rs138531570	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80918997G>A	ENST00000576599.1	-	8	1078	c.328C>T	c.(328-330)Cgc>Tgc	p.R110C	B3GNTL1_ENST00000320865.3_Missense_Mutation_p.R221C|B3GNTL1_ENST00000571954.1_5'UTR			Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	221							transferase activity, transferring glycosyl groups			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	8	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TGGTCCACGCGGATGACGCCG	0.697000													6	15					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17375071	17375071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17375071C>T	ENST00000252597.3	-	2	211	c.38G>A	c.(37-39)gGg>gAg	p.G13E	USHBP1_ENST00000431146.2_5'UTR|USHBP1_ENST00000598570.1_5'UTR	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	13							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						AGCATGCCTCCCTCGCCGGCT	0.657000													11	23					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34096010	34096010	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34096010C>T	ENST00000397527.1	+	32	7617	c.6897C>T	c.(6895-6897)acC>acT	p.T2299T	CEP250_ENST00000342580.4_Silent_p.T2243T	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	2299					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding	p.T2299T(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TGCGGAGTACCTTGGAGCAGG	0.567000													49	100					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103321104	103321104	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103321104G>A	ENST00000233969.2	+	10	2089	c.1947G>A	c.(1945-1947)agG>agA	p.R649R		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	649						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						AAAGCATTAGGAAGGACAGCA	0.512000													23	61					0	0	1	0	0
SERPINA6	866	broad.mit.edu	37	14	94776126	94776126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94776126G>A	ENST00000341584.3	-	3	977	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	277					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TCAGTGCAGCGATGACTGTGT	0.562000													34	89					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170716065	170716065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170716065G>A	ENST00000314251.3	-	10	1370	c.1291C>T	c.(1291-1293)Cca>Tca	p.P431S	SLC2A2_ENST00000382808.4_Missense_Mutation_p.P312S	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	431					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GCAGGACGTGGTCCTTGACTG	0.463000													24	75					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34003130	34003130	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34003130G>A	ENST00000373381.4	-	61	9887	c.9711C>T	c.(9709-9711)tcC>tcT	p.S3237S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3214	Sushi 26.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCAGGAGAAGGAGACAGATG	0.607000													28	74					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761935	92761935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92761935G>A	ENST00000318238.4	-	5	4566	c.3350C>T	c.(3349-3351)tCc>tTc	p.S1117F	SAMD9L_ENST00000411955.1_Missense_Mutation_p.S1117F|SAMD9L_ENST00000437805.1_Missense_Mutation_p.S1117F	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1117										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGAAATATAGGAATTTTTAGG	0.383000													38	131					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1208909	1208909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1208909C>T	ENST00000304460.10	+	2	307	c.251C>T	c.(250-252)cCc>cTc	p.P84L		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	84					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GAGGGCATCCCCCTGCTGTAC	0.667000													29	106					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112813	57112813	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57112813G>A	ENST00000454682.1	-	3	2782	c.2501C>T	c.(2500-2502)tCa>tTa	p.S834L	NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000548563.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGAAGAAATGAAGCTTCAAC	0.507000			T	BCL6	NHL								7	31					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831800	61831800	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61831800G>A	ENST00000280772.1	-	37	9030	c.8839C>T	c.(8839-8841)Cag>Tag	p.Q2947*	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2947					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGGAAGGCTGATCAAGCAAT	0.443000													30	71					0	0	1	0	0
BHMT	635	broad.mit.edu	37	5	78421875	78421875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78421875C>T	ENST00000274353.5	+	6	739	c.632C>T	c.(631-633)tCc>tTc	p.S211F	DMGDH_ENST00000520388.1_Intron|BHMT_ENST00000524080.1_Missense_Mutation_p.S58F	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	211	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding	p.S211Y(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	ACAGGAGCATCCATCATTGGT	0.493000													21	80					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90433383	90433383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90433383C>T	ENST00000394375.3	+	8	851	c.738C>T	c.(736-738)ttC>ttT	p.F246F	LIPF_ENST00000238983.4_Silent_p.F236F|LIPF_ENST00000355843.2_Silent_p.F203F	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	236					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		CACACAACTTCTTTGATCAAT	0.368000													83	154					0	0	1	0	0
FAM53A	152877	broad.mit.edu	37	4	1659150	1659150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1659150G>A	ENST00000308132.6	-	3	313	c.121C>T	c.(121-123)Cct>Tct	p.P41S	FAM53A_ENST00000489363.1_Missense_Mutation_p.P41S|FAM53A_ENST00000461064.1_Missense_Mutation_p.P41S|FAM53A_ENST00000472884.2_Missense_Mutation_p.P41S	NM_001174070.1	NP_001167541.1	Q6NSI3	FA53A_HUMAN	family with sequence similarity 53, member A	41						nucleus		p.P41S(1)		breast(2)|central_nervous_system(2)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			AGCTCCAAAGGGAACAGACGA	0.552000													4	20					0	0	1	0	0
PHF7	51533	broad.mit.edu	37	3	52454938	52454938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52454938C>T	ENST00000327906.3	+	7	1093	c.433C>T	c.(433-435)Cgc>Tgc	p.R145C	PHF7_ENST00000478707.1_Missense_Mutation_p.R145C|PHF7_ENST00000347025.2_Missense_Mutation_p.R145C	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	145						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		TGACAAACATCGCCCAACACA	0.493000													38	94					0	0	1	0	0
LMF2	91289	broad.mit.edu	37	22	50941853	50941853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50941853G>A	ENST00000216080.5	-	14	2184	c.2016C>T	c.(2014-2016)tcC>tcT	p.S672S	LMF2_ENST00000380796.3_Silent_p.S584S|LMF2_ENST00000474879.2_Silent_p.S697S			Q9BU23	LMF2_HUMAN	lipase maturation factor 2	697						endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCGAACTACTGGAGCAGGGGT	0.677000													15	28					0	0	1	0	0
LAMP3	27074	broad.mit.edu	37	3	182841908	182841908	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:182841908G>A	ENST00000265598.3	-	6	1467	c.1212C>T	c.(1210-1212)atC>atT	p.I404I	LAMP3_ENST00000466939.1_Silent_p.I380I	NM_014398.3	NP_055213.2	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	404					cell proliferation	integral to membrane|lysosomal membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(2)	28	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			ACCTTAGGCGGATTTTATAGA	0.453000													50	147					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633463	116633463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:116633463G>A	ENST00000260210.4	-	4	865	c.842C>T	c.(841-843)tCc>tTc	p.S281F	BUD13_ENST00000375445.3_Intron	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	281										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		TCTGGGCAGGGAATAAGTGAC	0.512000													64	112					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219299355	219299355	+	Missense_Mutation	SNP	G	G	A	rs143261714	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219299355G>A	ENST00000248444.5	+	14	1695	c.1607G>A	c.(1606-1608)cGg>cAg	p.R536Q	VIL1_ENST00000392114.2_Missense_Mutation_p.R225Q	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	536	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTCCCAGCGCGGGCCAATTTC	0.567000													31	90					0	0	1	0	0
C2CD2L	9854	broad.mit.edu	37	11	118986957	118986957	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118986957C>T	ENST00000336702.3	+	14	2474	c.2115C>T	c.(2113-2115)ccC>ccT	p.P705P	C2CD2L_ENST00000528586.1_3'UTR	NM_014807.3	NP_055622.3	O14523	C2C2L_HUMAN	C2CD2-like	704						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)	13						ACCCCAGCCCCCAGCTCTGAG	0.597000													14	50					0	0	1	0	0
ZNF568	374900	broad.mit.edu	37	19	37488068	37488068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37488068C>T	ENST00000455427.2	+	9	1612	c.1283C>T	c.(1282-1284)tCa>tTa	p.S428L		NM_001204839.1	NP_001191768.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGTTGTGCCTCACAGCTGAGT	0.428000													3	12					0	0	1	0	0
BAP1	8314	broad.mit.edu	37	3	52439273	52439273	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52439273G>A	ENST00000460680.1	-	11	1440	c.969C>T	c.(967-969)gcC>gcT	p.A323A	BAP1_ENST00000296288.5_Silent_p.A305A	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	323					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.A323fs*71(1)|p.P324fs*7(1)		NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		TGTGGGATGGGGCTTGTGCGC	0.592000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							59	136					0	0	1	0	0
RC3H1	149041	broad.mit.edu	37	1	173934254	173934254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173934254G>A	ENST00000367696.2	-	10	1690	c.1339C>T	c.(1339-1341)Cgt>Tgt	p.R447C	RC3H1_ENST00000258349.4_Missense_Mutation_p.R447C|RC3H1_ENST00000367694.2_Missense_Mutation_p.R447C			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	447					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						TTCATTTTACGAAATCTATAT	0.368000													18	56					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10092766	10092766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10092766C>T	ENST00000264828.3	-	32	2520	c.2435G>A	c.(2434-2436)gGa>gAa	p.G812E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	812	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCCTATGGGTCCCAGGGGACC	0.537000													15	45					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28598868	28598868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28598868C>T	ENST00000253063.3	+	4	749	c.428C>T	c.(427-429)cCt>cTt	p.P143L		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	143					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGGTGACCCTGAGTGGCTG	0.622000													21	128					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102811671	102811671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102811671G>A	ENST00000307046.8	-	4	694	c.513C>T	c.(511-513)atC>atT	p.I171I	IGF1_ENST00000392904.1_Intron|IGF1_ENST00000424202.2_Intron|IGF1_ENST00000337514.6_Intron|IGF1_ENST00000456098.1_Intron	NM_001111285.1	NP_001104755.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	171					anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding	p.I171M(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						TCTTTCCTCTGATCTGCAGAC	0.463000													199	379					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113681267	113681267	+	Silent	SNP	C	C	T	rs114751886	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113681267C>T	ENST00000397024.1	+	4	375	c.357C>T	c.(355-357)ctC>ctT	p.L119L	MCF2L_ENST00000375608.3_Intron|MCF2L_ENST00000421756.1_Intron|MCF2L_ENST00000375597.4_Intron|MCF2L_ENST00000375604.2_Intron|MCF2L_ENST00000375601.3_Intron|MCF2L_ENST00000423482.2_Intron|MCF2L_ENST00000397030.1_Intron|MCF2L_ENST00000535094.2_Intron|MCF2L_ENST00000434480.2_Intron|MCF2L_ENST00000442652.2_Intron			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	1055	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CTGATGTGCTCGTCCCAGCCT	0.577000													4	19					0	0	1	0	0
SH3TC2	79628	broad.mit.edu	37	5	148384333	148384333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148384333G>A	ENST00000515425.1	-	17	3909	c.3808C>T	c.(3808-3810)Ccc>Tcc	p.P1270S	SH3TC2_ENST00000512049.1_Missense_Mutation_p.P1263S|SH3TC2_ENST00000538184.1_3'UTR|SH3TC2_ENST00000502274.1_Missense_Mutation_p.P132S	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1270							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCCGGAGGGCCTGCTGTGC	0.642000													9	24					0	0	1	0	0
LRRC20	55222	broad.mit.edu	37	10	72061139	72061139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72061139G>A	ENST00000355790.4	-	5	1003	c.526C>T	c.(526-528)Ccg>Tcg	p.P176S	LRRC20_ENST00000395011.1_Missense_Mutation_p.P126S|LRRC20_ENST00000373224.1_Missense_Mutation_p.P176S|LRRC20_ENST00000395010.1_Missense_Mutation_p.P120S|LRRC20_ENST00000358141.2_Missense_Mutation_p.P126S	NM_001278212.1|NM_001278214.1|NM_207119.1	NP_001265141.1|NP_001265143.1|NP_997002.1	Q8TCA0	LRC20_HUMAN	leucine rich repeat containing 20	176										endometrium(2)|large_intestine(4)|lung(2)|urinary_tract(1)	9						GCGCCTTCCGGAGACATGAGC	0.647000													24	59					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8993436	8993436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8993436G>A	ENST00000397910.4	-	66	41856	c.41653C>T	c.(41653-41655)Ctg>Ttg	p.L13885L	MUC16_ENST00000380951.5_Silent_p.L526L	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13888	SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGTGGGTCAGCTGGCTCAGC	0.592000													19	216					0	0	1	0	0
ATP1A4	480	broad.mit.edu	37	1	160141149	160141149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160141149G>A	ENST00000368081.4	+	11	2071	c.1600G>A	c.(1600-1602)Gag>Aag	p.E534K		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	534					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GAATGGGCAGGAGTACTCAAT	0.512000													25	61					0	0	1	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249615	119249615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:119249615C>T	ENST00000217999.2	-	1	232	c.158G>A	c.(157-159)gGt>gAt	p.G53D	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	53					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						GTGGTTCACACCGCCCTCAGG	0.642000													42	30					0	0	1	0	0
GOLGA2	2801	broad.mit.edu	37	9	131021480	131021480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131021480G>A	ENST00000421699.2	-	19	1994	c.1982C>T	c.(1981-1983)gCc>gTc	p.A661V		NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	661						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						GGCCATCTCGGCCACCGCTTT	0.622000													12	30					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54958995	54958995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54958995G>A	ENST00000273286.5	-	2	417	c.255C>T	c.(253-255)tcC>tcT	p.S85S	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|LRTM1_ENST00000493075.1_Silent_p.S9S|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000490478.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	85						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		GATTTGAAAGGGAATTGTTGG	0.448000													14	32					0	0	1	0	0
LRPAP1	4043	broad.mit.edu	37	4	3516553	3516553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3516553C>T	ENST00000500728.2	-	7	1083	c.937G>A	c.(937-939)Gac>Aac	p.D313N	LRPAP1_ENST00000296325.5_5'UTR	NM_002337.3	NP_002328.1	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein associated protein 1	313	LDL receptor binding (Potential).				negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		CGCTCGCCGTCGCCCACGCTC	0.647000													19	86					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50163489	50163489	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50163489C>T	ENST00000376025.2	-	0	913							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					AGTGATTTTTCGTTGTGGTGT	0.383000													47	22					0	0	1	0	0
PTTG1	9232	broad.mit.edu	37	5	159851296	159851296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:159851296C>T	ENST00000393964.1	+	3	732	c.329C>T	c.(328-330)gCc>gTc	p.A110V	PTTG1_ENST00000519287.1_3'UTR|PTTG1_ENST00000352433.5_Missense_Mutation_p.A110V|PTTG1_ENST00000520452.1_Missense_Mutation_p.A110V			O95997	PTTG1_HUMAN	pituitary tumor-transforming 1	110					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|chromosome organization|chromosome segregation|DNA repair|mitosis|spermatogenesis|transcription from RNA polymerase II promoter	cytosol|nucleus	cysteine-type endopeptidase inhibitor activity|sequence-specific DNA binding transcription factor activity|SH3 domain binding			breast(1)|large_intestine(1)|lung(4)	6	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.00219)|Epithelial(171;0.00348)|all cancers(165;0.0104)		TCAGATGATGCCTATCCAGAA	0.378000													9	139					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36156555	36156555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:36156555G>A	ENST00000378660.1	+	10	1422	c.1234G>A	c.(1234-1236)Gaa>Aaa	p.E412K	CHDC2_ENST00000313548.4_Missense_Mutation_p.E412K					calponin homology domain containing 2																		TACTCTTTATGAAATTGACTT	0.289000													27	14					0	0	1	0	0
ACSL3	2181	broad.mit.edu	37	2	223795394	223795394	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:223795394C>T	ENST00000357430.3	+	14	2127	c.1596C>T	c.(1594-1596)ggC>ggT	p.G532G	ACSL3_ENST00000392066.3_Silent_p.G532G	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	532					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	TTATTGGGGGCCAAAGTGTGA	0.363000			T	ETV1	prostate								18	31					0	0	1	0	0
VOPP1	81552	broad.mit.edu	37	7	55565347	55565347	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55565347G>A	ENST00000285279.5	-	3	350	c.150C>T	c.(148-150)tgC>tgT	p.C50C	VOPP1_ENST00000433959.1_Silent_p.C41C|VOPP1_ENST00000454227.1_Intron|VOPP1_ENST00000453256.1_5'UTR|VOPP1_ENST00000428097.1_5'UTR|VOPP1_ENST00000471168.1_5'UTR|VOPP1_ENST00000428648.1_5'UTR|VOPP1_ENST00000545390.1_Silent_p.C47C|VOPP1_ENST00000418904.1_Silent_p.C33C|VOPP1_ENST00000427700.1_Silent_p.C48C	NM_030796.3	NP_110423.3	Q96AW1	VOPP1_HUMAN	vesicular, overexpressed in cancer, prosurvival protein 1	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity			endometrium(1)|lung(4)	5						CCCGCACACAGCACCTGGAGC	0.637000													17	75					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3030524	3030524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3030524G>A	ENST00000381127.1	+	11	1921	c.1700G>A	c.(1699-1701)gGg>gAg	p.G567E	ARSF_ENST00000359361.2_Missense_Mutation_p.G567E|ARSF_ENST00000537104.1_Missense_Mutation_p.G567E	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	567						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTTGCTGTGGGGTGTTCCCA	0.532000													26	15					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480622	140480622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140480622C>T	ENST00000231130.2	+	1	389	c.389C>T	c.(388-390)tCt>tTt	p.S130F	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		130	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATGACCATTCTCCGGTATTC	0.413000													45	107					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111066773	111066773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111066773C>T	ENST00000550703.2	+	4	830	c.674C>T	c.(673-675)cCt>cTt	p.P225L	TCTN1_ENST00000551555.2_Intron|TCTN1_ENST00000377654.3_Intron|TCTN1_ENST00000397655.3_Intron|TCTN1_ENST00000551590.1_Intron|TCTN1_ENST00000397659.4_Intron|HVCN1_ENST00000548312.1_Intron			Q2MV58	TECT1_HUMAN	tectonic family member 1	0					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						AATATCTTTCCTTGTAAGTTA	0.348000													15	33					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19822386	19822386	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19822386G>A	ENST00000344099.3	-	4	1842	c.1704C>T	c.(1702-1704)ttC>ttT	p.F568F		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	568					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				TGGAAGAAATGAAGGCTTTTC	0.413000													29	69					0	0	1	0	0
GCK	2645	broad.mit.edu	37	7	44228526	44228526	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44228526C>T	ENST00000403799.3	-	1	496	c.27G>A	c.(25-27)gaG>gaA	p.E9E	GCK_ENST00000476008.1_Intron|GCK_ENST00000437084.1_Silent_p.E9E	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	9					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						TCTTGGCGGCCTCCATCCTGG	0.562000													13	29					0	0	1	0	0
BTBD8	284697	broad.mit.edu	37	1	92568189	92568189	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:92568189G>A	ENST00000370382.3	+	3	774	c.507G>A	c.(505-507)gaG>gaA	p.E169E	BTBD8_ENST00000342818.3_Silent_p.E169E|BTBD8_ENST00000540648.1_Silent_p.E169E			Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	169						nucleus				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)	16		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		AAATTCCAGAGGATATCAGTG	0.328000													33	76					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317795	30317795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30317795C>T	ENST00000375377.1	-	3	1383	c.1282G>A	c.(1282-1284)Gat>Aat	p.D428N		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	428										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						AACCGTGGATCATCAAAGGGA	0.507000													36	110					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20048142	20048142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:20048142G>A	ENST00000400230.2	-	6	348	c.304C>T	c.(304-306)Ctt>Ttt	p.L102F	TPTE2_ENST00000255310.6_Missense_Mutation_p.L65F|TPTE2_ENST00000457266.2_Intron|TPTE2_ENST00000390680.2_Missense_Mutation_p.L65F|TPTE2_ENST00000382977.4_Missense_Mutation_p.L102F|TPTE2_ENST00000382975.4_Missense_Mutation_p.L102F|TPTE2_ENST00000382978.1_Missense_Mutation_p.L102F|TPTE2_ENST00000400103.2_Intron			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	102						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		GGAATATAAAGTTTGCTGTCA	0.323000													40	109					0	0	1	0	0
SLC10A6	345274	broad.mit.edu	37	4	87744939	87744939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:87744939C>T	ENST00000273905.6	-	6	1183	c.1036G>A	c.(1036-1038)Gag>Aag	p.E346K		NM_197965.2	NP_932069.1	Q3KNW5	SOAT_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 6	346						integral to membrane|plasma membrane	bile acid:sodium symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	9		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		TCATTCACCTCCAAGAAGGCA	0.498000													33	74					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	670560	670560	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:670560C>T	ENST00000266383.5	+	20	2953	c.2940C>T	c.(2938-2940)ttC>ttT	p.F980F		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	980						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGAATTTCTTCCATCATTTCC	0.592000													7	31					0	0	1	0	0
DRGX	644168	broad.mit.edu	37	10	50574376	50574376	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50574376G>A	ENST00000374139.2	-	6	587	c.577C>T	c.(577-579)Ctt>Ttt	p.L193F	DRGX_ENST00000434016.1_Missense_Mutation_p.L198F			C9JW76	C9JW76_HUMAN	dorsal root ganglia homeobox	198					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	11						TAGGTGGGAAGGAAGGAGAGT	0.602000													28	72					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6107481	6107481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6107481C>T	ENST00000409021.3	-	3	792	c.343G>A	c.(343-345)Gcc>Acc	p.A115T	JAKMIP1_ENST00000457227.2_Intron|JAKMIP1_ENST00000410077.2_Intron|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.A115T|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.A115T|JAKMIP1_ENST00000409371.3_Intron	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	115	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTCAGCGTGGCCTGCAGCCGC	0.726000													3	17					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227919421	227919421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227919421G>A	ENST00000396625.3	-	31	2956	c.2749C>T	c.(2749-2751)Ccc>Tcc	p.P917S	COL4A4_ENST00000329662.7_Missense_Mutation_p.P917S	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	917	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CTTTCTCCGGGAAAACCTGGG	0.512000													16	51					0	0	1	0	0
ZFYVE27	118813	broad.mit.edu	37	10	99512938	99512938	+	Splice_Site	SNP	C	C	T	rs149770775		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99512938C>T	ENST00000393677.4	+	10	1245	c.1042_splice	c.e10+1	p.F347_splice	ZFYVE27_ENST00000370613.3_Splice_Site_p.F222_splice|ZFYVE27_ENST00000453958.2_Splice_Site_p.F340_splice|ZFYVE27_ENST00000337540.7_Splice_Site_p.F308_splice|ZFYVE27_ENST00000359980.3_Splice_Site_p.F340_splice|ZFYVE27_ENST00000356257.4_Splice_Site_p.F352_splice|ZFYVE27_ENST00000370610.3_Splice_Site_p.F247_splice|ZFYVE27_ENST00000357540.4_Splice_Site_p.F254_splice	NM_144588.6	NP_653189.3	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27	347					cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	8		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		CCAACAACTTCGGTGCGGCCA	0.647000													6	12					0	0	1	0	0
POP4	10775	broad.mit.edu	37	19	30106194	30106194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30106194C>T	ENST00000585603.1	+	7	2872	c.570C>T	c.(568-570)ggC>ggT	p.G190G	POP4_ENST00000392279.3_Silent_p.G109G|POP4_ENST00000591824.1_3'UTR|POP4_ENST00000221770.3_Silent_p.G66G			O95707	RPP29_HUMAN	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)	190					mRNA cleavage|rRNA processing|tRNA processing	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease P activity|RNA binding			breast(1)|endometrium(1)|lung(4)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			AAACCGATGGCTTTATTTCCT	0.383000													23	49					0	0	1	0	0
METTL1	4234	broad.mit.edu	37	12	58163367	58163367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58163367G>A	ENST00000324871.7	-	4	1263	c.554C>T	c.(553-555)gCc>gTc	p.A185V	METTL1_ENST00000257848.7_Silent_p.C123C	NM_005371.5	NP_005362.3	Q9UBP6	TRMB_HUMAN	methyltransferase like 1	185						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding			large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	4	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			TAGCACGTAGGCATATTCTGC	0.527000													42	96					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190234050	190234050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190234050C>T	ENST00000367462.3	-	4	794	c.563G>A	c.(562-564)aGg>aAg	p.R188K	FAM5C_ENST00000484105.1_5'UTR|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000534846.1_Missense_Mutation_p.R86K	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		188						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGTGCTGTCCCTGTCAATGAA	0.443000													45	99					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51289566	51289566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51289566C>T	ENST00000261842.5	+	18	2496	c.2390C>T	c.(2389-2391)tCa>tTa	p.S797L	AP4E1_ENST00000560508.1_Missense_Mutation_p.S722L	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	797					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		AGAAGGAAATCAAAAGTCAAA	0.323000													24	31					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156629387	156629387	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156629387G>A	ENST00000296518.7	+	5	526		c.e5-1		GUCY1A3_ENST00000511108.1_Splice_Site|GUCY1A3_ENST00000455639.2_Splice_Site|GUCY1A3_ENST00000515602.1_Splice_Site|GUCY1A3_ENST00000513574.1_Splice_Site|GUCY1A3_ENST00000393832.3_Splice_Site|GUCY1A3_ENST00000511507.1_Splice_Site|GUCY1A3_ENST00000506455.1_Splice_Site			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3						blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		AATATTTCCAGGAAATCTTTG	0.264000													27	47					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133698359	133698359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133698359C>T	ENST00000310926.4	-	2	473	c.200G>A	c.(199-201)aGt>aAt	p.S67N	SLCO2A1_ENST00000478651.1_5'UTR|SLCO2A1_ENST00000493729.1_Missense_Mutation_p.S67N	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	67					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						CGATGAAGAACTGGAGAGCCC	0.547000													41	109					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100226899	100226899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100226899C>T	ENST00000524871.1	+	25	3541	c.3251C>T	c.(3250-3252)tCg>tTg	p.S1084L	CNTN5_ENST00000279463.3_Missense_Mutation_p.S1084L|CNTN5_ENST00000528682.1_Missense_Mutation_p.S1084L|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000418526.2_Missense_Mutation_p.S1010L	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	1084					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCCACATCTTCGTCATCAGTC	0.418000													6	20					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37650510	37650510	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37650510C>T	ENST00000399151.3	+	30	5911	c.5826C>T	c.(5824-5826)gcC>gcT	p.A1942A		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1942					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CACTCAGTGCCTACAATGCTC	0.522000													23	120					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26802553	26802553	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26802553G>A	ENST00000376236.4	+	8	1232	c.777G>A	c.(775-777)gaG>gaA	p.E259E		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	259	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TATTTTTGGAGAAAGAGGAGA	0.313000													40	113					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73879550	73879550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73879550C>T	ENST00000342056.2	+	12	2005	c.1607C>T	c.(1606-1608)cCa>cTa	p.P536L	KCNQ5_ENST00000414165.2_Intron|KCNQ5_ENST00000403813.2_Missense_Mutation_p.P508L|KCNQ5_ENST00000402622.2_Missense_Mutation_p.P527L|KCNQ5_ENST00000370398.1_Missense_Mutation_p.P517L|KCNQ5_ENST00000355635.3_Missense_Mutation_p.P518L|KCNQ5_ENST00000355194.4_Missense_Mutation_p.P517L	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	517					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CTCACCCCACCACTTAAAACT	0.403000													6	41					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156812901	156812901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156812901G>A	ENST00000368195.3	-	17	3417	c.3021C>T	c.(3019-3021)tcC>tcT	p.S1007S	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	1007	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCACGGGTGTGGACTCCTCTC	0.572000													16	52					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904255	73904255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73904255C>T	ENST00000342056.2	+	15	2372	c.1974C>T	c.(1972-1974)ctC>ctT	p.L658L	KCNQ5_ENST00000414165.2_Silent_p.L529L|KCNQ5_ENST00000403813.2_Silent_p.L630L|KCNQ5_ENST00000402622.2_Silent_p.L649L|KCNQ5_ENST00000370398.1_Silent_p.L639L|KCNQ5_ENST00000355635.3_Silent_p.L640L|KCNQ5_ENST00000355194.4_Silent_p.L639L	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	639					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CCTCAGCCCTCGCTTTGGCTT	0.473000													6	48					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202710650	202710650	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202710650G>A	ENST00000367265.3	-	19	3954	c.2790C>T	c.(2788-2790)ccC>ccT	p.P930P	KDM5B_ENST00000367264.2_Silent_p.P966P	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	930					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TAAGGGAGCTGGGGTCTAGGC	0.522000													22	41					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133208969	133208969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:133208969G>A	ENST00000320574.5	-	45	6305	c.6262C>T	c.(6262-6264)Cct>Tct	p.P2088S	POLE_ENST00000535270.1_Missense_Mutation_p.P2061S	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	2088					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGGAGGACAGGAAACATCTCT	0.522000								DNA polymerases (catalytic subunits)					9	68					0	0	1	0	0
PTGIS	5740	broad.mit.edu	37	20	48124509	48124509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:48124509C>T	ENST00000244043.4	-	10	1480	c.1451G>A	c.(1450-1452)gGt>gAt	p.G484D	PTGIS_ENST00000478971.1_5'UTR	NM_000961.3	NP_000952.1	Q16647	PTGIS_HUMAN	prostaglandin I2 (prostacyclin) synthase	484					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CTGCATCAGACCGAAGCCGTA	0.602000													13	38					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104174892	104174892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104174892G>A	ENST00000020673.5	-	4	1378	c.852C>T	c.(850-852)tcC>tcT	p.S284S	PSD_ENST00000406432.1_Silent_p.S284S	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	284					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGTCTGTCTCGGAGTACTTGG	0.662000													16	45					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4534035	4534035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4534035C>T	ENST00000381848.3	-	2	132	c.52G>A	c.(52-54)Gac>Aac	p.D18N	PLIN5_ENST00000586133.1_Missense_Mutation_p.D18N|PLIN5_ENST00000592610.1_Missense_Mutation_p.D18N|CTB-50L17.14_ENST00000586020.1_Silent_p.R35R	NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	18						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						ACCTGCTGGTCCTGCTCCCAC	0.612000													5	8					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24528509	24528509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24528509C>T	ENST00000342740.5	+	21	1811	c.1657C>T	c.(1657-1659)Cgg>Tgg	p.R553W	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	553										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GGCAGACTCCCGGCTGAAGCT	0.657000													16	31					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38861371	38861371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38861371C>T	ENST00000409235.3	+	29	3534	c.3419C>T	c.(3418-3420)tCc>tTc	p.S1140F	CATSPERG_ENST00000410018.1_Missense_Mutation_p.S1100F|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	1140					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						ATGTTCAGCTCCAGGATGACA	0.562000													26	114					0	0	1	0	0
NDC1	55706	broad.mit.edu	37	1	54262797	54262797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54262797G>A	ENST00000371429.3	-	12	1841	c.1243C>T	c.(1243-1245)Cca>Tca	p.P415S	NDC1_ENST00000234725.8_Missense_Mutation_p.P300S|NDC1_ENST00000537333.1_Missense_Mutation_p.P80S|NDC1_ENST00000540001.1_Missense_Mutation_p.P415S	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		CTAGATTTTGGTGTCTGAAAA	0.428000													32	63					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497486	141497486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141497486G>A	ENST00000264952.2	+	1	497	c.360G>A	c.(358-360)ggG>ggA	p.G120G		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	120	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CTGCCCCGGGGAACCCGCAAC	0.672000													9	33					0	0	1	0	0
GPR156	165829	broad.mit.edu	37	3	119886646	119886646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119886646G>A	ENST00000464295.1	-	10	2123	c.1678C>T	c.(1678-1680)Cct>Tct	p.P560S	GPR156_ENST00000461057.1_Missense_Mutation_p.P556S|GPR156_ENST00000315843.3_Missense_Mutation_p.P560S			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	560						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		GAAGCCTCAGGGCCCAGGCCC	0.587000													57	117					0	0	1	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65209693	65209693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65209693C>T	ENST00000380230.3	+	3	276	c.247C>T	c.(247-249)Ctc>Ttc	p.L83F	AC069368.3_ENST00000437723.1_Intron|ANKDD1A_ENST00000319580.8_Intron|ANKDD1A_ENST00000491145.1_3'UTR|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.L83F|ANKDD1A_ENST00000496660.1_Intron|ANKDD1A_ENST00000357698.3_Missense_Mutation_p.L83F	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	83					signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						GGTAGGGGCCCTCACAGAGGC	0.637000													4	10					0	0	1	0	0
ZNF34	80778	broad.mit.edu	37	8	145999601	145999601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145999601G>A	ENST00000429371.2	-	6	823	c.670C>T	c.(670-672)Cct>Tct	p.P224S	ZNF34_ENST00000343459.4_Missense_Mutation_p.P245S	NM_030580.3	NP_085057.3	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		TTCCCAGTAGGAATTTTCTGA	0.403000													12	25					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38723952	38723952	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:38723952G>A	ENST00000342213.2	-	1	1622	c.1276C>T	c.(1276-1278)Cac>Tac	p.H426Y		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	426						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GGGCTTTCGTGAAAGCAGAGC	0.562000													25	32					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61834595	61834595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61834595C>T	ENST00000280772.1	-	37	6235	c.6044G>A	c.(6043-6045)aGa>aAa	p.R2015K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2015					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TACTTGCACTCTCTCTGGCAG	0.443000													26	115					0	0	1	0	0
OSBPL3	26031	broad.mit.edu	37	7	24874210	24874210	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:24874210C>T	ENST00000313367.2	-	15	2092	c.1641G>A	c.(1639-1641)gtG>gtA	p.V547V	OSBPL3_ENST00000352860.1_Silent_p.V516V|OSBPL3_ENST00000409069.1_Silent_p.V480V|OSBPL3_ENST00000353930.1_Silent_p.V511V|OSBPL3_ENST00000396429.1_Silent_p.V511V|OSBPL3_ENST00000396431.1_Silent_p.V516V|OSBPL3_ENST00000431825.2_Silent_p.V480V	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	547					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						CGTTCAGCTCCACCGGCATGG	0.637000													26	56					0	0	1	0	0
CERK	64781	broad.mit.edu	37	22	47116007	47116007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:47116007G>A	ENST00000216264.8	-	3	467	c.355C>T	c.(355-357)Ctg>Ttg	p.L119L	CERK_ENST00000541677.1_5'UTR	NM_022766.5	NP_073603.2	Q8TCT0	CERK1_HUMAN	ceramide kinase	119	Required for binding to sulfatide and phosphoinositides.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	20		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ATCTCCCGCAGGGTCTGCAGC	0.572000													26	73					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32554771	32554771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32554771C>T	ENST00000286827.3	-	16	3325	c.2854G>A	c.(2854-2856)Gag>Aag	p.E952K	TIAM1_ENST00000541036.1_Missense_Mutation_p.E892K	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	952					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						AGGGGGCTCTCGCCAAGGTCG	0.662000													8	15					0	0	1	0	0
PDP2	57546	broad.mit.edu	37	16	66919186	66919186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66919186C>T	ENST00000311765.2	+	2	1333	c.999C>T	c.(997-999)atC>atT	p.I333I	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	333					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GGACGATCATCATGGAGGACA	0.587000													6	47					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2869055	2869055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2869055C>T	ENST00000155840.5	+	16	1961	c.1853C>T	c.(1852-1854)tCc>tTc	p.S618F	KCNQ1-AS1_ENST00000440887.2_RNA|KCNQ1_ENST00000526095.1_3'UTR|KCNQ1_ENST00000335475.5_Missense_Mutation_p.S491F	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	618	Subunits assembly domain.				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CAGCTGCTCTCCTTGCACGGT	0.692000													4	5					0	0	1	0	0
ZNF556	80032	broad.mit.edu	37	19	2877742	2877742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2877742G>A	ENST00000586426.1	+	4	870	c.783G>A	c.(781-783)aaG>aaA	p.K261K	ZNF556_ENST00000307635.2_Silent_p.K262K			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGAGTGCAAGCACTGTGGGA	0.537000													17	42					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21965021	21965021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21965021G>A	ENST00000261200.4	-	34	4172	c.4173C>T	c.(4171-4173)atC>atT	p.I1391I	ABCC9_ENST00000261201.4_Silent_p.I1391I|ABCC9_ENST00000345162.2_Silent_p.I1355I	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1391	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCTGCAGAATGATTGAAAGTC	0.383000													11	112					0	0	1	0	0
SPRYD7	57213	broad.mit.edu	37	13	50505152	50505152	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:50505152A>G	ENST00000361840.3	-	2	328		c.e2+1		SPRYD7_ENST00000378195.2_Intron	NM_020456.2	NP_065189.1	Q5W111	SPRY7_HUMAN	SPRY domain containing 7											haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)	6						CATTATACCAACCTGTGGACT	0.313000													15	49					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166897921	166897921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166897921G>A	ENST00000423058.2	-	13	2252	c.2235C>T	c.(2233-2235)ttC>ttT	p.F745F	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Silent_p.F734F|SCN1A_ENST00000303395.4_Silent_p.F745F|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.F717F	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	745						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCCAGATTAAGAATATGTTGG	0.373000													38	126					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56768600	56768600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:56768600C>T	ENST00000381295.2	+	18	2776	c.2428C>T	c.(2428-2430)Cgt>Tgt	p.R810C	EXOC1_ENST00000349598.6_Missense_Mutation_p.R795C|EXOC1_ENST00000346134.7_Missense_Mutation_p.R810C	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	810					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					ACAAGAACTTCGTAAAGTCAT	0.383000													29	59					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10669536	10669536	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:10669536C>T	ENST00000226951.6	-	2	198		c.e2-1		CLNK_ENST00000442825.2_Splice_Site	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker						immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						TCAATTCAGCCTGTGGAAACA	0.478000													4	18					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73045661	73045661	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:73045661G>A	ENST00000545377.1	+	3	209		c.e3-1		ARHGEF28_ENST00000426542.2_Splice_Site|ARHGEF28_ENST00000437974.1_Splice_Site|ARHGEF28_ENST00000513042.2_Splice_Site|ARHGEF28_ENST00000287898.5_Splice_Site|ARHGEF28_ENST00000296794.6_Splice_Site	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		TCCTTTTTCAGGGGCAGATGA	0.418000													16	49					0	0	1	0	0
ZNF579	163033	broad.mit.edu	37	19	56090216	56090216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56090216G>A	ENST00000325421.4	-	2	818	c.790C>T	c.(790-792)Ccg>Tcg	p.P264S		NM_152600.2	NP_689813.2	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		GGGCGTGGCGGGGGCCCCCCT	0.721000													4	15					0	0	1	0	0
MUC13	56667	broad.mit.edu	37	3	124627180	124627180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124627180C>T	ENST00000311075.3	-	11	1388	c.1350G>A	c.(1348-1350)acG>acA	p.T450T		NM_033049.3	NP_149038.3	Q9H3R2	MUC13_HUMAN	mucin 13, cell surface associated	450						extracellular region|integral to membrane|plasma membrane		p.T450T(1)		breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(1)|stomach(1)	18						CAATATGCTTCGTTTTGTTAT	0.343000													16	34					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43505518	43505518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43505518C>T	ENST00000400427.1	+	4	779	c.383C>T	c.(382-384)tCc>tTc	p.S128F	UMODL1_ENST00000400424.1_Missense_Mutation_p.S128F|UMODL1_ENST00000408910.2_Missense_Mutation_p.S200F|UMODL1_ENST00000408989.2_Missense_Mutation_p.S200F	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	200	WAP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CTTCTGCATTCCTTGGTAGGT	0.607000													33	177					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21265245	21265245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21265245C>T	ENST00000233242.1	-	3	352	c.225G>A	c.(223-225)agG>agA	p.R75R	APOB_ENST00000399256.4_Silent_p.R75R	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	75	Heparin-binding.|Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGCAGTTGATCCTGGTGGCAC	0.587000													34	89					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64504407	64504407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64504407C>T	ENST00000377494.1	-	8	1835	c.913G>A	c.(913-915)Ggt>Agt	p.G305S	RASGRP2_ENST00000354024.3_Missense_Mutation_p.G305S|RASGRP2_ENST00000377497.3_Missense_Mutation_p.G305S|RASGRP2_ENST00000394432.3_Missense_Mutation_p.G305S			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	305	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGGTGCACACCCAGGATCGGG	0.652000													13	34					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23066116	23066116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23066116G>A	ENST00000246006.4	-	1	861	c.714C>T	c.(712-714)ttC>ttT	p.F238F		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	238					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCTTGCACAGGAAATAATGAC	0.592000													41	131					0	0	1	0	0
DIRAS2	54769	broad.mit.edu	37	9	93375806	93375806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:93375806C>T	ENST00000375765.3	-	2	692	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	102					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity	p.E102K(3)		kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						CAGATTTGTTCGTAGATGGGC	0.592000													10	106					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30026560	30026560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:30026560G>A	ENST00000346128.6	-	12	1908	c.1434C>T	c.(1432-1434)atC>atT	p.I478I	TJP1_ENST00000356107.6_Silent_p.I478I|TJP1_ENST00000400011.2_Silent_p.I482I|TJP1_ENST00000545208.2_Silent_p.I478I	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	478	PDZ 3.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CTTCTCTTATGATATTTGTAA	0.363000													29	77					0	0	1	0	0
ANKRD29	147463	broad.mit.edu	37	18	21209887	21209887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21209887G>A	ENST00000592179.1	-	6	612	c.458C>T	c.(457-459)gCc>gTc	p.A153V	ANKRD29_ENST00000284207.7_Missense_Mutation_p.A153V|ANKRD29_ENST00000322980.9_Missense_Mutation_p.A153V	NM_173505.2	NP_775776.2	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	153										breast(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)	13	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ACCACCTTGGGCAGCTAGGAA	0.438000													4	40					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112958820	112958820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112958820C>T	ENST00000271277.6	+	3	258	c.33C>T	c.(31-33)ctC>ctT	p.L11L	RP4-671G15.2_ENST00000502356.2_RNA	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	11						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGCCTGAACTCCTGACACTAT	0.343000													33	103					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209179022	209179022	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:209179022C>T	ENST00000264380.4	+	14	1859	c.1701C>T	c.(1699-1701)tcC>tcT	p.S567S		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	567					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						ACTTAGAATCCTTATTTAATC	0.373000													30	85					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3147762	3147762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3147762G>A	ENST00000263650.7	-	3	319	c.160C>T	c.(160-162)Ccg>Tcg	p.P54S	OSBPL5_ENST00000389989.3_Missense_Mutation_p.P54S|OSBPL5_ENST00000348039.5_Missense_Mutation_p.P54S|OSBPL5_ENST00000525498.1_Missense_Mutation_p.P6S|OSBPL5_ENST00000542243.1_5'UTR	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	54					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGCAGCGACGGGCCGTTGGGC	0.657000													9	23					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109704794	109704794	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109704794G>A	ENST00000356711.2	+	25	3079	c.2953G>A	c.(2953-2955)Gaa>Aaa	p.E985K	MYO16_ENST00000457511.2_Missense_Mutation_p.E497K|MYO16_ENST00000357550.2_Missense_Mutation_p.E985K	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	985	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AATTATTGGAGAAAACAAGAA	0.313000													27	69					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17749924	17749924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17749924C>T	ENST00000428389.2	-	26	3312	c.3313G>A	c.(3313-3315)Gaa>Aaa	p.E1105K	UNC13A_ENST00000552293.1_Missense_Mutation_p.E1017K|UNC13A_ENST00000519716.2_Missense_Mutation_p.E1017K|UNC13A_ENST00000551649.1_Missense_Mutation_p.E1017K|UNC13A_ENST00000550896.1_Missense_Mutation_p.E1015K|UNC13A_ENST00000252773.7_Missense_Mutation_p.E1017K			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1017	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CTGTACAGTTCATGGCAGTTA	0.542000													4	20					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106208522	106208522	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106208522G>A	ENST00000390548.2	-	0	377																											GTTTTGGGGGGAAGAGGAAGA	0.612000													35	58					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169519217	169519217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169519217C>T	ENST00000367796.3	-	10	1634	c.1433G>A	c.(1432-1434)gGg>gAg	p.G478E	F5_ENST00000546081.1_3'UTR|F5_ENST00000367797.3_Missense_Mutation_p.G478E			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	478	F5/8 type A 2.|Plastocyanin-like 3.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATAGGTTTCCCCTGGTTGAAC	0.353000													38	146					0	0	1	0	0
C7orf66	154907	broad.mit.edu	37	7	108524513	108524513	+	Missense_Mutation	SNP	C	C	T	rs145510967		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:108524513C>T	ENST00000379007.2	-	1	131	c.77G>A	c.(76-78)aGc>aAc	p.S26N		NM_001024607.1	NP_001019778.1	A4D0T2	CG066_HUMAN	chromosome 7 open reading frame 66	26						integral to membrane				breast(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	15						GCAACTGAGGCTCCAAAGTCT	0.383000													6	46					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111154973	111154973	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111154973C>T	ENST00000280325.4	+	3	327	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	60										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		AGCCCTACTTCCCCCAGGAGC	0.662000													45	87					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24858320	24858320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:24858320G>A	ENST00000424834.2	+	7	2685	c.2212G>A	c.(2212-2214)Ggt>Agt	p.G738S	SPATA13_ENST00000343003.6_Missense_Mutation_p.G57S|SPATA13_ENST00000409126.1_Missense_Mutation_p.G35S|SPATA13_ENST00000399949.2_Missense_Mutation_p.G35S|SPATA13_ENST00000382108.3_Missense_Mutation_p.G738S|SPATA13_ENST00000382095.4_Missense_Mutation_p.G113S			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	113					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GGATGACAACGgtagtgagga	0.493000													17	30					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35242161	35242161	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:35242161T>A	ENST00000408931.3	-	8	1751	c.1225A>T	c.(1225-1227)Agt>Tgt	p.S409C		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	409						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GTGGGGCCACTCCCTTGCATG	0.557000													7	27					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42680109	42680109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42680109C>T	ENST00000358131.5	+	4	810	c.602C>T	c.(601-603)tCa>tTa	p.S201L	TOX2_ENST00000372999.1_Missense_Mutation_p.S150L|TOX2_ENST00000435864.2_Missense_Mutation_p.S70L|TOX2_ENST00000423191.1_Missense_Mutation_p.S150L|TOX2_ENST00000341197.3_Missense_Mutation_p.S192L	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGCTCCCCATCACCGCCGGGG	0.637000													7	24					0	0	1	0	0
CREB3L1	90993	broad.mit.edu	37	11	46334007	46334007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:46334007G>A	ENST00000529193.1	+	6	1336	c.885G>A	c.(883-885)cgG>cgA	p.R295R	CREB3L1_ENST00000288400.3_Silent_p.R295R			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	295					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		AGAGAGTCCGGAGGAAAATCA	0.587000			T	FUS	myxofibrosarcoma								14	16					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692426	135692426	+	Missense_Mutation	SNP	G	G	A	rs138178870	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135692426G>A	ENST00000513104.1	-	2	932	c.650C>T	c.(649-651)tCg>tTg	p.S217L	TRPC7_ENST00000355180.3_Missense_Mutation_p.S217L|TRPC7_ENST00000426057.2_Missense_Mutation_p.S217L	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	217					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTCATGCGCGAGCGCGAGTG	0.612000													14	32					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86954766	86954766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86954766G>A	ENST00000234701.3	+	9	1621	c.1270G>A	c.(1270-1272)Gag>Aag	p.E424K	CLCA1_ENST00000394711.1_Missense_Mutation_p.E424K			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	424	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GTGCTTTAACGAGGTCAAACA	0.468000													16	71					0	0	1	0	0
CACTIN	58509	broad.mit.edu	37	19	3623996	3623996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3623996G>A	ENST00000429344.2	-	2	384	c.332C>T	c.(331-333)cCt>cTt	p.P111L	CACTIN_ENST00000248420.5_Missense_Mutation_p.P111L|CACTIN_ENST00000221899.3_Missense_Mutation_p.P43L	NM_001080543.1	NP_001074012.1			cactin, spliceosome C complex subunit																		TGAGGAGCTAGGAGACCACGA	0.701000													6	15					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596678	179596678	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179596678C>T	ENST00000589042.1	-	58	17148	c.16924G>A	c.(16924-16926)Gaa>Aaa	p.E5642K	TTN_ENST00000342992.6_Missense_Mutation_p.E4398K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E5325K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5325	Ig-like 37.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTTAAATTCCTTGGTAAAA	0.443000													10	74					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17614117	17614117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:17614117G>A	ENST00000377813.1	-	8	2901	c.2598C>T	c.(2596-2598)gtC>gtT	p.V866V	RRBP1_ENST00000360807.4_Silent_p.V433V|RRBP1_ENST00000246043.4_Silent_p.V866V|RRBP1_ENST00000455029.2_Silent_p.V207V|RRBP1_ENST00000377807.2_Silent_p.V433V			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	866					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						GCAGCTGCAGGACCTGCTTCT	0.637000													7	71					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952570	54952570	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54952570G>A	ENST00000273286.5	-	3	1116	c.954C>T	c.(952-954)gcC>gcT	p.A318A	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|LRTM1_ENST00000493075.1_Silent_p.A242A|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000490478.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	318						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		CATGGTACTGGGCTGTGATTG	0.517000													80	147					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143093720	143093720	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:143093720G>A	ENST00000367603.2	-	5	2898	c.2156C>T	c.(2155-2157)aCt>aTt	p.T719I	HIVEP2_ENST00000012134.2_Missense_Mutation_p.T719I|HIVEP2_ENST00000367604.1_Missense_Mutation_p.T719I	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	719					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GCCCACAGGAGTGCTTACAAT	0.507000													24	59					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176445	57176445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57176445G>A	ENST00000537055.2	-	2	353	c.122C>T	c.(121-123)gCc>gTc	p.A41V		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						TCCCTTGCAGGCCACGGCCTC	0.597000													16	69					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38793988	38793988	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38793988C>T	ENST00000359357.3	+	27	3507	c.3253C>T	c.(3253-3255)Cga>Tga	p.R1085*	DNAH8_ENST00000449981.2_Nonsense_Mutation_p.R1302*|DNAH8_ENST00000441566.1_Nonsense_Mutation_p.R1085*					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTTACTCTGTCGATATCTGAA	0.328000													16	44					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67304727	67304727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67304727G>A	ENST00000299798.11	+	16	2370	c.2305G>A	c.(2305-2307)Ggg>Agg	p.G769R		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	769					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		GAGTGGGCAGGGGGACCTGGC	0.597000													16	50					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225750837	225750837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:225750837G>A	ENST00000409592.3	-	6	650	c.537C>T	c.(535-537)tcC>tcT	p.S179S	DOCK10_ENST00000258390.7_Silent_p.S185S			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	185							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AGAGCCAGCCGGACTTGAAAA	0.498000													12	119					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67290926	67290926	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67290926C>T	ENST00000299798.11	+	7	1310	c.1245C>T	c.(1243-1245)ctC>ctT	p.L415L		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	415					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CCTTTGCTCTCGTCATCCTAC	0.557000													54	113					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340788	121340788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121340788G>A	ENST00000338040.4	+	3	926	c.512G>A	c.(511-513)gGa>gAa	p.G171E		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	171					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GAAATGGGAGGAGCAGTGGGT	0.493000													16	32					0	0	1	0	0
CARD10	29775	broad.mit.edu	37	22	37891882	37891882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37891882C>T	ENST00000403299.1	-	15	2404	c.2188G>A	c.(2188-2190)Gag>Aag	p.E730K	CARD10_ENST00000406271.3_Missense_Mutation_p.E444K|CARD10_ENST00000251973.5_Missense_Mutation_p.E730K			Q9BWT7	CAR10_HUMAN	caspase recruitment domain family, member 10	730					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					CGAAGGATCTCTTGGGCTTTC	0.622000													18	53					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993545	140993545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140993545C>T	ENST00000285879.4	+	4	641	c.355C>T	c.(355-357)Cct>Tct	p.P119S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	119							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGAGCCCTCCTGAGGGTGA	0.522000										HNSCC(15;0.026)			40	57					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	169997050	169997050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169997050C>T	ENST00000263816.3	-	72	13399	c.13114G>A	c.(13114-13116)Gaa>Aaa	p.E4372K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4372					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATAGGCAGTTCGATGGCTGCA	0.547000													12	29					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125844486	125844486	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125844486C>T	ENST00000393434.2	-	15	2122	c.1773G>A	c.(1771-1773)ggG>ggA	p.G591G	ALDH1L1_ENST00000273450.3_Silent_p.G601G|ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000472186.1_Silent_p.G591G|ALDH1L1_ENST00000452905.2_Silent_p.G490G	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	591	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CCACTGTGTTCCCGGCAGCCA	0.572000													26	74					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32945427	32945427	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32945427C>T	ENST00000340811.4	-	13	2554		c.e13-1		PKP2_ENST00000070846.6_Splice_Site	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2						cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TAAACTGAGCCTTTGGAATAA	0.428000													15	76					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20161138	20161138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:20161138C>T	ENST00000263754.4	+	8	1654	c.1199C>T	c.(1198-1200)tCa>tTa	p.S400L		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	400					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						AATTCAACCTCATCTTCCCTT	0.502000													35	68					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73676009	73676009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73676009G>A	ENST00000339764.1	+	4	1172	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	RP11-167N4.2_ENST00000540886.1_RNA|RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000537753.1_5'UTR	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	141					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					CCCCCAAGTCGAACGGGATCT	0.527000											OREG0021218	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	63					0	0	1	0	0
TMPRSS2	7113	broad.mit.edu	37	21	42866339	42866339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42866339G>A	ENST00000398585.3	-	3	353	c.293C>T	c.(292-294)tCc>tTc	p.S98F	TMPRSS2_ENST00000458356.1_Missense_Mutation_p.S61F|TMPRSS2_ENST00000497881.1_Intron|TMPRSS2_ENST00000332149.5_Missense_Mutation_p.S61F	NM_001135099.1	NP_001128571.1	O15393	TMPS2_HUMAN	transmembrane protease, serine 2	61					proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ETV1(34)|TMPRSS2/ETV5_ENST00000306376(5)|TMPRSS2/ERG(3582)|TMPRSS2/ETV4(13)	central_nervous_system(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				GACGGGGTTGGAAGCCTGCGT	0.602000			T	"""ERG, ETV1, ETV4, ETV5"""	prostate								12	40					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26825473	26825473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:26825473G>A	ENST00000541819.2	-	7	945	c.843C>T	c.(841-843)ttC>ttT	p.F281F	GABRB3_ENST00000545868.1_Silent_p.F140F|GABRB3_ENST00000400188.3_Silent_p.F154F|GABRB3_ENST00000299267.4_Silent_p.F225F|GABRB3_ENST00000311550.5_Silent_p.F225F			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	225					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CACCTGTGGCGAAGACAACAT	0.572000													31	63					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214171118	214171118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:214171118G>A	ENST00000366958.4	+	2	1848	c.1240G>A	c.(1240-1242)Gac>Aac	p.D414N	PROX1_ENST00000261454.4_Missense_Mutation_p.D414N|PROX1_ENST00000435016.1_Missense_Mutation_p.D414N|PROX1_ENST00000498508.2_Missense_Mutation_p.D414N	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	414					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GTGCTTTGGCGACGTCATCAT	0.562000													22	112					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85447412	85447412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85447412C>T	ENST00000394573.1	+	7	748	c.546C>T	c.(544-546)ttC>ttT	p.F182F	SLC28A1_ENST00000286749.3_Silent_p.F182F|SLC28A1_ENST00000538177.1_Silent_p.F182F|SLC28A1_ENST00000537624.1_Silent_p.F182F|SLC28A1_ENST00000537216.1_Silent_p.F182F|SLC28A1_ENST00000537703.1_Silent_p.F104F	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	182					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGGTGTCCTTCGCAGGAATCT	0.592000													40	109					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448522	155448522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155448522G>A	ENST00000368346.3	-	3	4778	c.4139C>T	c.(4138-4140)cCa>cTa	p.P1380L	ASH1L_ENST00000392403.3_Missense_Mutation_p.P1380L			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1380	Pro-rich.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			ACCATAAGATGGATAGAATCC	0.453000													23	52					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81697929	81697929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81697929G>A	ENST00000372292.3	-	8	847	c.807C>T	c.(805-807)ggC>ggT	p.G269G		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	269	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			GTTTTACAAAGCCTGCTGTCT	0.542000													32	91					0	0	1	0	0
WDR36	134430	broad.mit.edu	37	5	110436354	110436354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110436354C>T	ENST00000506538.2	+	5	1217	c.644C>T	c.(643-645)aCc>aTc	p.T215I	WDR36_ENST00000513710.2_Missense_Mutation_p.T215I|WDR36_ENST00000505303.1_Missense_Mutation_p.T159I	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	215					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		CATCCAAGTACCTACTTGAAT	0.294000													4	56					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66191710	66191710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66191710C>T	ENST00000311034.2	+	7	1525	c.1349C>T	c.(1348-1350)aCc>aTc	p.T450I		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	450					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CATTTGCCCACCCCATCCAGC	0.562000													82	187					0	0	1	0	0
NFKBIB	4793	broad.mit.edu	37	19	39396066	39396066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39396066C>T	ENST00000392079.3	+	3	512	c.414C>T	c.(412-414)ccC>ccT	p.P138P	NFKBIB_ENST00000313582.5_Silent_p.P170P|NFKBIB_ENST00000572515.1_Silent_p.P170P			Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	170					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	8	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			ACCGTACTCCCGACACCAACC	0.657000													28	64					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80718764	80718764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:80718764G>A	ENST00000299564.8	-	2	442	c.287C>T	c.(286-288)cCt>cTt	p.P96L	CDYL2_ENST00000562753.1_5'UTR|CDYL2_ENST00000563890.1_Missense_Mutation_p.P96L|CDYL2_ENST00000566173.1_Missense_Mutation_p.P96L|CDYL2_ENST00000562812.1_Missense_Mutation_p.P96L	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	96						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						GCTCTTTCCAGGATCTGAAGG	0.547000													8	50					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35622914	35622914	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35622914G>A	ENST00000392225.3	-	4	866	c.347C>T	c.(346-348)tCt>tTt	p.S116F	LGI4_ENST00000493050.1_5'UTR|LGI4_ENST00000591633.1_Missense_Mutation_p.S116F|LGI4_ENST00000310123.3_Missense_Mutation_p.S116F			Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	116						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCATTCTTAGAGATGGAGCC	0.607000													5	9					0	0	1	0	0
MYADM	91663	broad.mit.edu	37	19	54377181	54377181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54377181C>T	ENST00000391769.2	+	3	678	c.398C>T	c.(397-399)tCg>tTg	p.S133L	MYADM_ENST00000336967.3_Missense_Mutation_p.S133L|MYADM_ENST00000391768.2_Missense_Mutation_p.S133L|MYADM_ENST00000391771.1_Missense_Mutation_p.S133L|MYADM_ENST00000391770.4_Missense_Mutation_p.S133L	NM_001020821.1	NP_001018657.1	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	133	MARVEL 1.					integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		CACGGCCGTTCGCGGGACCAC	0.652000													34	101					0	0	1	0	0
PDE9A	5152	broad.mit.edu	37	21	44189219	44189219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:44189219G>A	ENST00000291539.6	+	17	1604	c.1544G>A	c.(1543-1545)gGg>gAg	p.G515E	PDE9A_ENST00000398232.3_Missense_Mutation_p.G448E|PDE9A_ENST00000398227.3_Missense_Mutation_p.G355E|PDE9A_ENST00000398224.3_Missense_Mutation_p.G388E|PDE9A_ENST00000398236.3_Missense_Mutation_p.G429E|PDE9A_ENST00000380328.2_Missense_Mutation_p.G462E|PDE9A_ENST00000349112.3_Missense_Mutation_p.G387E|PDE9A_ENST00000398229.3_Missense_Mutation_p.G381E|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000335440.6_Missense_Mutation_p.G413E|PDE9A_ENST00000398234.3_Missense_Mutation_p.G414E|PDE9A_ENST00000335512.4_Missense_Mutation_p.G455E|PDE9A_ENST00000539837.1_Missense_Mutation_p.G387E|PDE9A_ENST00000398225.3_Missense_Mutation_p.G474E|PDE9A_ENST00000328862.6_Missense_Mutation_p.G489E	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	515	Catalytic (By similarity).				platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						GCCCAGATTGGGTTCATCAAG	0.507000													28	51					0	0	1	0	0
HOXB9	3219	broad.mit.edu	37	17	46700315	46700315	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46700315G>A	ENST00000311177.5	-	2	907	c.700C>T	c.(700-702)Cag>Tag	p.Q234*	HOXB7_ENST00000567101.1_Intron|HOXB9_ENST00000550387.1_3'UTR	NM_024017.4	NP_076922.1	P17482	HXB9_HUMAN	homeobox B9	234					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|large_intestine(1)|liver(1)|lung(6)|prostate(1)	12						CGCCGGTTCTGAAACCAGATT	0.463000													8	93					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95107144	95107144	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95107144C>T	ENST00000469935.1	+	0	83					NR_015340.1																						tttctgtaaccttgtgatgtg	0.582000													5	7					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756861	94756861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94756861G>A	ENST00000554723.1	-	2	608	c.190C>T	c.(190-192)Ccc>Tcc	p.P64S	SERPINA10_ENST00000261994.4_Missense_Mutation_p.P24S|SERPINA10_ENST00000554173.1_Missense_Mutation_p.P24S|SERPINA10_ENST00000393096.1_Missense_Mutation_p.P24S			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	24					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TGAGGACTGGGGGCCAAGCCG	0.642000													4	17					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127767930	127767930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:127767930G>A	ENST00000483725.3	-	5	1870	c.1534C>T	c.(1534-1536)Ccc>Tcc	p.P512S	SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	512							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		TTCTTGGTGGGATTATCAGGC	0.473000													6	43					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31286972	31286972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31286972C>T	ENST00000544665.3	+	9	1032	c.961C>T	c.(961-963)Ctg>Ttg	p.L321L	ITGAM_ENST00000287497.8_Silent_p.L321L	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	321	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CTTTGAGGCTCTGAAGACCAT	0.557000													5	57					0	0	1	0	0
AL132709.8	0	broad.mit.edu	37	14	101431122	101431122	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101431122G>A	ENST00000423708.3	+	0	736																											CTGGATTGATGATATGATGGC	0.363000													23	51					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38830525	38830525	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38830525C>T	ENST00000449082.2	-	3	391	c.392G>A	c.(391-393)tGg>tAg	p.W131*		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	131					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TAAACTGAACCACCTGAAAGG	0.383000													13	28					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552609	1552609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1552609C>T	ENST00000381605.4	-	3	572	c.508G>A	c.(508-510)Gag>Aag	p.E170K	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000262929.5_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	170	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCATGGGACTCGCAGGTGAAG	0.567000													34	112					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11721000	11721000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11721000C>T	ENST00000389825.3	+	6	924	c.613C>T	c.(613-615)Ctt>Ttt	p.L205F	GREB1_ENST00000381486.2_Intron|GREB1_ENST00000234142.5_Intron|GREB1_ENST00000263834.5_Intron|GREB1_ENST00000381483.2_Intron			Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	0						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCCTGCTCTTCTTTGGGCCAA	0.617000													11	22					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63548115	63548115	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:63548115G>A	ENST00000397968.2	+	12	2769	c.2343G>A	c.(2341-2343)gaG>gaA	p.E781E	CDH7_ENST00000323011.3_Silent_p.E781E	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	781					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				CTGGCCAAGAGAGTTTGTACT	0.373000													16	85					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57757027	57757027	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57757027C>T	ENST00000360716.3	+	12	1743	c.1522C>T	c.(1522-1524)Ccc>Tcc	p.P508S	CCDC135_ENST00000394337.4_Missense_Mutation_p.P508S|CCDC135_ENST00000336825.8_Missense_Mutation_p.P443S			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	508						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						GCCTGGCCACCCCCAGGCTCT	0.597000													24	111					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21157616	21157616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21157616C>T	ENST00000377122.4	-	7	1057	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377119.1_Missense_Mutation_p.E221K	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	221					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TTAGAAGCTTCCACGGCATGT	0.343000													21	198					0	0	1	0	0
DBX1	120237	broad.mit.edu	37	11	20181561	20181561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20181561C>T	ENST00000524983.2	-	1	598	c.310G>A	c.(310-312)Gag>Aag	p.E104K	DBX1_ENST00000227256.3_Missense_Mutation_p.E104K			A6NMT0	DBX1_HUMAN	developing brain homeobox 1	104					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)	21						AACGTCGTCTCGCTGGCAGGG	0.677000													5	12					0	0	1	0	0
PRSS8	5652	broad.mit.edu	37	16	31144657	31144657	+	Silent	SNP	G	G	A	rs143732587	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31144657G>A	ENST00000317508.6	-	3	419	c.156C>T	c.(154-156)gtC>gtT	p.V52V	PRSS8_ENST00000568261.1_Silent_p.V52V	NM_002773.3	NP_002764.1	Q16651	PRSS8_HUMAN	protease, serine, 8	52	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	8						ACTGACCGGCGACTGCACTGC	0.637000													6	48					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151891543	151891543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151891543C>T	ENST00000355193.2	-	29	4707	c.4489G>A	c.(4489-4491)Gac>Aac	p.D1497N	KMT2C_ENST00000262189.6_Missense_Mutation_p.D1497N					lysine (K)-specific methyltransferase 2C																		ACCATTTTGTCTAGTTCAGGA	0.373000													13	117					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81173324	81173324	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81173324G>A	ENST00000394685.3	+	6	883	c.464G>A	c.(463-465)gGa>gAa	p.G155E	KIAA1199_ENST00000356249.5_Missense_Mutation_p.G155E|KIAA1199_ENST00000220244.3_Missense_Mutation_p.G155E			Q8WUJ3	K1199_HUMAN	KIAA1199	155	G8.									breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GAGTTGCATGGACAGAAAAAG	0.502000													39	159					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15917200	15917200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15917200G>A	ENST00000338282.6	-	3	520	c.414C>T	c.(412-414)atC>atT	p.I138I	MYH11_ENST00000300036.5_Silent_p.I138I|MYH11_ENST00000452625.2_Silent_p.I138I|MYH11_ENST00000396324.3_Silent_p.I138I|MYH11_ENST00000576790.1_Silent_p.I138I	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	138	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						ACATGTCGACGATCTTCTCCG	0.552000			T	CBFB	AML								28	62					0	0	1	0	0
TRAP1	10131	broad.mit.edu	37	16	3725373	3725373	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3725373G>A	ENST00000575671.1	-	3	942	c.213C>T	c.(211-213)ttC>ttT	p.F71F	TRAP1_ENST00000573872.1_5'UTR|TRAP1_ENST00000538171.1_Silent_p.F227F|TRAP1_ENST00000246957.5_Silent_p.F280F			Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1	280					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding	p.F280F(1)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(90;0.0261)				GGAAGCTGACGAAGTTGCTGT	0.488000													7	47					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61947987	61947987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61947987C>T	ENST00000422202.1	+	20	2696	c.2628C>T	c.(2626-2628)ttC>ttT	p.F876F	COL20A1_ENST00000326996.6_Silent_p.F869F|COL20A1_ENST00000435874.1_Silent_p.F876F|COL20A1_ENST00000358894.6_Silent_p.F869F			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	869	TSP N-terminal.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CCTCTGCCTTCGGTGGGACCC	0.647000													3	6					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56647797	56647797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56647797C>T	ENST00000389934.3	-	26	4003	c.3886G>A	c.(3886-3888)Gca>Aca	p.A1296T	TEX14_ENST00000240361.8_Missense_Mutation_p.A1302T|TEX14_ENST00000349033.5_Missense_Mutation_p.A1256T	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	1302						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGTCACATGCCTTAACAAGG	0.423000													43	97					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58520251	58520251	+	Splice_Site	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58520251T>A	ENST00000302819.5	-	3	452		c.e3-2		ACOX2_ENST00000459701.2_Splice_Site	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain						bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TGATGCTCTCTGCAGAGGACA	0.498000													24	51					0	0	1	0	0
THOP1	7064	broad.mit.edu	37	19	2790449	2790449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2790449C>T	ENST00000307741.6	+	2	250	c.47C>T	c.(46-48)tCt>tTt	p.S16F		NM_003249.3	NP_003240.1	P52888	THOP1_HUMAN	thimet oligopeptidase 1	16					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|lung(8)|ovary(2)|skin(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACGCAGCATCTCCGTGCTCT	0.602000													39	80					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116055828	116055828	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116055828C>T	ENST00000369271.3	-	19	2719		c.e19-1		AFAP1L2_ENST00000491814.1_5'UTR|AFAP1L2_ENST00000545353.1_Splice_Site|AFAP1L2_ENST00000304129.4_Splice_Site	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2						inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TCTCCCATTCCTAGGGTACCA	0.393000													23	239					0	0	1	0	0
SLPI	6590	broad.mit.edu	37	20	43881651	43881651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43881651G>A	ENST00000338380.2	-	3	406	c.386C>T	c.(385-387)cCt>cTt	p.P129L		NM_003064.2	NP_003055.1	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	129	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			lung(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				ACCTTTCACAGGGGAAACGCA	0.567000													29	88					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171584	150171584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150171584C>T	ENST00000307271.3	+	4	1741	c.1167C>T	c.(1165-1167)atC>atT	p.I389I		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	389						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ATGGTCTCATCCAGAAGTGTA	0.428000													42	173					0	0	1	0	0
SLC19A1	6573	broad.mit.edu	37	21	46950876	46950876	+	Missense_Mutation	SNP	G	G	A	rs56138890		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46950876G>A	ENST00000311124.4	-	4	1111	c.959C>T	c.(958-960)aCg>aTg	p.T320M	SLC19A1_ENST00000380010.4_Missense_Mutation_p.T320M|SLC19A1_ENST00000485649.2_Missense_Mutation_p.T280M|SLC19A1_ENST00000567670.1_Missense_Mutation_p.T320M	NM_194255.2	NP_919231.1	P41440	S19A1_HUMAN	solute carrier family 19 (folate transporter), member 1	320					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GGCGAAGGACGTGATGGCGCC	0.701000													5	14					0	0	1	0	0
ZNF253	56242	broad.mit.edu	37	19	20003140	20003140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20003140C>T	ENST00000589717.1	+	4	1176	c.1084C>T	c.(1084-1086)Cat>Tat	p.H362Y	ZNF253_ENST00000355650.4_Missense_Mutation_p.H286Y	NM_021047.2	NP_066385.2	O75346	ZN253_HUMAN	zinc finger protein 253	362				Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TAAGATACTTCATACTGGAGA	0.383000													10	90					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109677760	109677760	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109677760C>T	ENST00000338432.7	+	35	4907	c.4788C>T	c.(4786-4788)ttC>ttT	p.F1596F	ACACB_ENST00000377848.3_Silent_p.F1596F|ACACB_ENST00000543201.1_Silent_p.F262F|ACACB_ENST00000377854.5_Silent_p.F1526F			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1596					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TCCTCAACTTCGTGCCCACTG	0.607000													45	61					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807483	20807483	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20807483T>A	ENST00000601440.1	-	4	1346	c.1200A>T	c.(1198-1200)gaA>gaT	p.E400D	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TGCCACATTCTTCACATTTGT	0.398000													8	116					0	0	1	0	0
RNASE10	338879	broad.mit.edu	37	14	20979118	20979118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20979118G>A	ENST00000430083.1	+	2	976	c.572G>A	c.(571-573)gGg>gAg	p.G191E	RNASE10_ENST00000328444.5_Missense_Mutation_p.G163E			Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	163						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	12	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		GAGCTCAAGGGGGGAAAATGT	0.473000													20	48					0	0	1	0	0
DBN1	1627	broad.mit.edu	37	5	176885201	176885201	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176885201T>G	ENST00000292385.5	-	13	2249	c.1640A>C	c.(1639-1641)gAc>gCc	p.D547A	DBN1_ENST00000393565.1_Missense_Mutation_p.D591A|DBN1_ENST00000309007.5_Missense_Mutation_p.D545A|DBN1_ENST00000393563.4_Missense_Mutation_p.D277A|DBN1_ENST00000512501.1_Missense_Mutation_p.D277A	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	545					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCTCTGGGTCACAGAAGGT	0.652000													10	64					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91779643	91779643	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91779643C>T	ENST00000389857.6	-	15	2603	c.2517G>A	c.(2515-2517)aaG>aaA	p.K839K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	839					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				GCTTGGCCTCCTTCTCCAGCA	0.627000													31	94					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35763096	35763096	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:35763096G>A	ENST00000187397.4	+	14	1451		c.e14-1		ARPP21_ENST00000337271.5_Splice_Site|ARPP21_ENST00000444190.1_Splice_Site|ARPP21_ENST00000417925.1_Splice_Site|ARPP21_ENST00000458225.1_Splice_Site	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa							cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						TCGTACTCCAGGGGCAACAGA	0.527000													5	22					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65220510	65220510	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65220510C>T	ENST00000389722.3	-	32	6400	c.6345_splice	c.e32-1	p.G2116_splice	SPTB_ENST00000556626.1_Splice_Site_p.G2116_splice|SPTB_ENST00000342835.4_5'UTR	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	0					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTCTTCTTCCCCCTGCTCAGG	0.597000													20	63					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43221192	43221192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43221192C>T	ENST00000255226.6	+	8	1826	c.1010C>T	c.(1009-1011)cCc>cTc	p.P337L	SLC14A2_ENST00000586448.1_Missense_Mutation_p.P337L	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	337						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTGGCCACACCCTTCGAGACC	0.572000													19	42					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609614	84609614	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84609614G>A	ENST00000344803.2	+	4	4276	c.4229G>A	c.(4228-4230)aGg>aAg	p.R1410K		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AAAGACACTAGGGAGTTCCTA	0.498000													7	17					0	0	1	0	0
GAGE2A	729447	broad.mit.edu	37	X	49355801	49355801	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:49355801C>T	ENST00000362097.1	+	3	166	c.81_splice	c.e3-1	p.P28_splice		NM_001127212.1	NP_001120684.1			G antigen 2A											endometrium(4)	4	Ovarian(276;0.236)					ATTCCCCAGCCCGAGCAGTTC	0.438000													100	425					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18113665	18113665	+	Missense_Mutation	SNP	G	G	A	rs150320186		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18113665G>A	ENST00000403915.1	+	3	1841	c.1390G>A	c.(1390-1392)Gat>Aat	p.D464N	KCNS3_ENST00000465292.1_Intron|KCNS3_ENST00000304101.4_Missense_Mutation_p.D464N			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	464					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity	p.D464N(3)		endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TGTGGTGAGCGATCCTGACTC	0.453000													36	74					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14548453	14548453	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14548453C>T	ENST00000273083.3	-	0	2318							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						TCACTGGTCTCACTGAGGCTG	0.607000													4	14					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121379469	121379469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121379469G>A	ENST00000297848.3	+	46	5407	c.5137G>A	c.(5137-5139)Ggc>Agc	p.G1713S	COL14A1_ENST00000247781.3_Missense_Mutation_p.G1618S|COL14A1_ENST00000309791.4_Missense_Mutation_p.G1713S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1713	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AGGTCCAAGAGGCCCCCCTGG	0.373000													15	45					0	0	1	0	0
TBX19	9095	broad.mit.edu	37	1	168278043	168278043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168278043C>T	ENST00000367821.3	+	7	1031	c.980C>T	c.(979-981)tCc>tTc	p.S327F	TBX19_ENST00000465440.1_3'UTR	NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	327					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					AGCTGGACTTCCTTATCCTCC	0.473000													35	115					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131744851	131744851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131744851C>T	ENST00000372577.2	+	16	1561	c.1540C>T	c.(1540-1542)Cct>Tct	p.P514S		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	514					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						CCTTCGCATACCTCAAGGCAC	0.428000													26	80					0	0	1	0	0
SULT1C4	27233	broad.mit.edu	37	2	108998338	108998338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108998338G>A	ENST00000272452.2	+	2	616	c.290G>A	c.(289-291)gGa>gAa	p.G97E	SULT1C4_ENST00000409309.3_Missense_Mutation_p.G97E	NM_006588.2	NP_006579.2	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member 4	97					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						CCATCCTTAGGATCTGGTGAG	0.373000													18	76					0	0	1	0	0
OPN4	94233	broad.mit.edu	37	10	88418324	88418324	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88418324C>T	ENST00000372071.2	+	5	768	c.541C>T	c.(541-543)Ctg>Ttg	p.L181L	OPN4_ENST00000241891.5_Silent_p.L170L	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	170					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						GGACCGCTACCTGGTAATCAC	0.612000													13	69					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44488448	44488448	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44488448G>A	ENST00000425708.2	-	7	3056	c.2715C>T	c.(2713-2715)ttC>ttT	p.F905F	ZNF445_ENST00000396077.2_Silent_p.F905F			P59923	ZN445_HUMAN	zinc finger protein 445	905					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GTCTCCCAATGAACTCTTTCC	0.483000													40	92					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111311669	111311669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111311669C>T	ENST00000308208.5	+	5	635	c.393C>T	c.(391-393)atC>atT	p.I131I	CCDC63_ENST00000550317.1_3'UTR|CCDC63_ENST00000552694.1_Silent_p.I52I|CCDC63_ENST00000545036.1_Silent_p.I91I	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	131										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						AAAAAAAAATCGCAAACCAAA	0.403000													30	64					0	0	1	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148747925	148747925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148747925C>T	ENST00000514349.1	+	5	1502	c.923C>T	c.(922-924)tCc>tTc	p.S308F	PCYOX1L_ENST00000274569.4_Missense_Mutation_p.S398F			Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like	398					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	p.S398F(1)		breast(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGTCCAGTCCCCCAAGCCC	0.597000											OREG0016912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	156					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663986	169663986	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169663986C>T	ENST00000483289.2	-	0	3308				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						CATACAAAGCCCTCGGCATGC	0.498000													9	110					0	0	1	0	0
RAB9BP1	9366	broad.mit.edu	37	5	104435525	104435525	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:104435525C>T	ENST00000522464.1	-	0	68				RP11-6N13.1_ENST00000503650.1_lincRNA																							CAAAAGCTTTCCTTTTGTAAT	0.413000													13	41					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201012658	201012658	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201012658C>T	ENST00000362061.3	-	40	5025	c.4797_splice	c.e40-1	p.R1600_splice	CACNA1S_ENST00000367338.3_Splice_Site_p.R1581_splice	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1600					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GCCTCCAGTCCTCTAGGGGCA	0.577000											OREG0014067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	59					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192078283	192078283	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:192078283C>T	ENST00000454309.2	-	2	1069	c.244G>A	c.(244-246)Gga>Aga	p.G82R	FGF12_ENST00000264730.3_Missense_Mutation_p.G20R|FGF12_ENST00000445105.1_Missense_Mutation_p.G20R|FGF12_ENST00000430714.1_Intron|FGF12_ENST00000450716.1_Missense_Mutation_p.G20R	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	82					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		AGGAAGTATCCCTGCTGGCTG	0.398000													28	61					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74276934	74276934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74276934C>T	ENST00000262765.5	-	9	4045	c.3866G>A	c.(3865-3867)cGg>cAg	p.R1289Q		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1289							protein binding	p.R1289Q(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CTGTTTCTGCCGATGGTCCTC	0.622000													22	62					0	0	1	0	0
IRF8	3394	broad.mit.edu	37	16	85952165	85952165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:85952165G>A	ENST00000268638.5	+	7	1166	c.744G>A	c.(742-744)gaG>gaA	p.E248E	IRF8_ENST00000562492.1_Silent_p.E44E	NM_002163.2	NP_002154.1	Q02556	IRF8_HUMAN	interferon regulatory factor 8	248					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	24		Prostate(104;0.0771)				AGGGCCTGGAGCTGGTGCGCT	0.731000													18	34					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72473587	72473587	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72473587C>T	ENST00000360141.3	+	4	834	c.546C>T	c.(544-546)ctC>ctT	p.L182L	CD300A_ENST00000310828.5_Silent_p.L69L|CD300A_ENST00000361933.3_Intron|CD300A_ENST00000392625.3_Silent_p.L69L|CD300A_ENST00000577511.1_Silent_p.L52L	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	182					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						TCCCGCTGCTCCTCTCCCTGC	0.493000													16	43					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166892662	166892662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166892662G>A	ENST00000423058.2	-	16	3342	c.3325C>T	c.(3325-3327)Ccc>Tcc	p.P1109S	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.P1098S|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.P1109S|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.P1081S	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1109						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTAAGACTGGGGTTGTTTATG	0.358000													56	114					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190129977	190129977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190129977G>A	ENST00000367462.3	-	7	1236	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.F233F	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		335						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					ATGTGTTGAGGAAATAATTCA	0.299000													37	84					0	0	1	0	0
UBE2U	148581	broad.mit.edu	37	1	64671346	64671346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:64671346G>A	ENST00000371077.4	+	2	515	c.91G>A	c.(91-93)Gaa>Aaa	p.E31K	UBE2U_ENST00000371076.3_Missense_Mutation_p.E31K			Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)	31							ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(3)|lung(2)|skin(1)	6						GCCTGTAAGTGAAGATATGAT	0.289000													29	72					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248309077	248309077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248309077C>T	ENST00000366476.1	+	1	628	c.628C>T	c.(628-630)Cct>Tct	p.P210S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GATTGTTTTTCCTGTTGCAAT	0.418000													72	344					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92715464	92715464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92715464G>A	ENST00000257068.2	+	2	1081	c.1075G>A	c.(1075-1077)Gca>Aca	p.A359T		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	359					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GCAGCACCAGGCAGATGCTCT	0.592000													20	42					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31624191	31624191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31624191G>A	ENST00000379416.3	-	4	249	c.201C>T	c.(199-201)caC>caT	p.H67H		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	67	2Fe-2S ferredoxin-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGGCAGAAAAGTGGCTAGAAC	0.507000													5	46					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107956544	107956544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:107956544C>T	ENST00000285311.3	-	1	910	c.205G>A	c.(205-207)Ggc>Agc	p.G69S	DKK2_ENST00000513208.1_Intron|DKK2_ENST00000510463.1_Intron	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	69					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		AGGTTTTTGCCCTTCTTACTG	0.577000													11	77					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123989933	123989933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123989933C>T	ENST00000369005.1	+	16	8445	c.8105C>T	c.(8104-8106)tCc>tTc	p.S2702F	TACC2_ENST00000334433.3_Missense_Mutation_p.S2702F|TACC2_ENST00000358010.1_Missense_Mutation_p.S848F|TACC2_ENST00000369004.3_Intron|TACC2_ENST00000513429.1_Missense_Mutation_p.S848F|TACC2_ENST00000369001.1_Intron|TACC2_ENST00000369000.1_Intron|TACC2_ENST00000515603.1_Intron|TACC2_ENST00000360561.3_Intron|TACC2_ENST00000368999.1_Missense_Mutation_p.S792F|TACC2_ENST00000260733.3_Missense_Mutation_p.S780F|TACC2_ENST00000515273.1_Intron|TACC2_ENST00000453444.2_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2702						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCTTTGGCTTCCCGCAGCCAC	0.592000													32	66					0	0	1	0	0
ABHD12	26090	broad.mit.edu	37	20	25287509	25287509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:25287509G>A	ENST00000339157.5	-	10	1182	c.910C>T	c.(910-912)Cct>Tct	p.P304S	ABHD12_ENST00000376542.3_Missense_Mutation_p.P304S|ABHD12_ENST00000481556.1_5'UTR	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	304						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						CTTGTAATAGGATCAAGGAAG	0.378000													8	52					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202490	248202490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248202490C>T	ENST00000366479.2	+	1	1017	c.921C>T	c.(919-921)atC>atT	p.I307I	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTCAGAAAATCTTCTCAGTGA	0.423000													20	100					0	0	1	0	0
NDE1	54820	broad.mit.edu	37	16	15793636	15793636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15793636C>T	ENST00000396353.2	+	10	1824	c.998C>T	c.(997-999)tCg>tTg	p.S333L	NDE1_ENST00000342673.5_Intron|NDE1_ENST00000396355.1_Intron|NDE1_ENST00000396354.1_Intron			Q9NXR1	NDE1_HUMAN	nudE neurodevelopment protein 1	333					cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13						ATGTCTTCATCGCCGCTGCCG	0.512000													8	16					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49896972	49896972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49896972C>T	ENST00000477224.1	-	11	1763	c.1285G>A	c.(1285-1287)Gcc>Acc	p.A429T	CAMKV_ENST00000463537.1_Silent_p.Q360Q|CAMKV_ENST00000296471.7_Missense_Mutation_p.A401T|CAMKV_ENST00000467248.1_Missense_Mutation_p.A354T|CAMKV_ENST00000466940.1_Missense_Mutation_p.A355T|CAMKV_ENST00000488336.1_Missense_Mutation_p.A398T			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	429	Ala-rich.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CCATCAGTGGCTGGAGTAGCG	0.632000													40	72					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730073	96730073	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96730073C>T	ENST00000216629.6	+	3	660	c.54C>T	c.(52-54)ctC>ctT	p.L18L	BDKRB1_ENST00000553356.1_Silent_p.L18L|RP11-404P21.8_ENST00000553811.1_3'UTR|RP11-404P21.8_ENST00000555847.1_3'UTR|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	18					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		AGAGCCAGCTCTTCCCTCAAA	0.517000													12	21					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49898258	49898258	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49898258C>T	ENST00000477224.1	-	8	1144	c.666G>A	c.(664-666)gaG>gaA	p.E222E	CAMKV_ENST00000463537.1_Silent_p.E222E|CAMKV_ENST00000296471.7_Silent_p.E194E|CAMKV_ENST00000467248.1_Silent_p.E147E|CAMKV_ENST00000466940.1_Silent_p.E179E|CAMKV_ENST00000488336.1_Silent_p.E222E			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	222	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CTTCCACCTCCTCATAGAAAG	0.488000													53	134					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924294	188924294	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:188924294C>T	ENST00000326866.4	+	4	741	c.333C>T	c.(331-333)ttC>ttT	p.F111F	ZFP42_ENST00000509524.1_Silent_p.F111F	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	111					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AAAAGGTTTTCGAAGCAAGCT	0.408000													35	87					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400505	40400505	+	Silent	SNP	C	C	T	rs141680440	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:40400505C>T	ENST00000338305.6	-	2	890	c.348G>A	c.(346-348)ggG>ggA	p.G116G		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	116						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGGTGTCCTCCCCAAGGCTTG	0.587000													18	31					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40827457	40827457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40827457G>A	ENST00000396617.3	-	6	681	c.91C>T	c.(91-93)Cgt>Tgt	p.R31C	MKL1_ENST00000402630.1_Missense_Mutation_p.R31C|MKL1_ENST00000402042.1_Missense_Mutation_p.R31C|MKL1_ENST00000407029.1_Missense_Mutation_p.R31C|MKL1_ENST00000355630.3_Missense_Mutation_p.R31C			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	31	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						GGCCGGGAACGAATCTTCCGT	0.473000			T	RBM15	acute megakaryocytic leukemia								94	177					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215844336	215844336	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215844336G>A	ENST00000366943.2	-	64	14497	c.14111C>T	c.(14110-14112)cCt>cTt	p.P4704L	USH2A_ENST00000307340.3_Missense_Mutation_p.P4704L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4704	Fibronectin type-III 32.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTCTGTGAAAGGCAATAGTTC	0.378000										HNSCC(13;0.011)			41	139					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63488441	63488441	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:63488441C>G	ENST00000374852.3	-	14	2158	c.2091G>C	c.(2089-2091)gaG>gaC	p.E697D	MTMR8_ENST00000453546.1_Intron	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	697						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						AGTAGTCTGCCTCCTTGGTGC	0.522000													23	19					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61231327	61231327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61231327G>A	ENST00000382768.1	+	5	679	c.679G>A	c.(679-681)Gtg>Atg	p.V227M	SERPINB12_ENST00000269491.1_Missense_Mutation_p.V207M			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	207			K -> E (in dbSNP:rs35582068).		negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TGAAAACACGGTGGATGCACC	0.408000													8	95					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861395	55861395	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55861395C>T	ENST00000302124.2	+	1	643	c.612C>T	c.(610-612)ttC>ttT	p.F204F	OR8I2_ENST00000560768.1_3'UTR			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					TAGCTGGATTCACTCTTCTTA	0.453000													26	98					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29294507	29294507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29294507C>T	ENST00000331664.5	-	1	2620	c.2621G>A	c.(2620-2622)aGg>aAg	p.R874K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	874					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CCATGTTCTCCTGGTGGGGCC	0.622000													24	68					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837306	82837306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82837306C>T	ENST00000265077.3	+	8	9049	c.8484C>T	c.(8482-8484)ccC>ccT	p.P2828P	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Silent_p.P1841P|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2828	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CATCATCTCCCCTCACTATCT	0.498000													21	129					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70017033	70017033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70017033C>T	ENST00000355303.5	+	22	2543	c.2238C>T	c.(2236-2238)ttC>ttT	p.F746F	ANO1_ENST00000538023.1_Silent_p.F746F|ANO1_ENST00000531349.1_Silent_p.F455F|ANO1_ENST00000398543.2_Silent_p.F600F|ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000530676.1_Silent_p.F600F	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	746					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TCGCCTCCTTCCCCCTGGCCC	0.587000													6	18					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14756399	14756399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14756399G>A	ENST00000380881.4	-	30	6198	c.5383C>T	c.(5383-5385)Cca>Tca	p.P1795S	FREM1_ENST00000380894.1_Missense_Mutation_p.P330S|FREM1_ENST00000422223.2_Missense_Mutation_p.P1794S|FREM1_ENST00000380880.3_Missense_Mutation_p.P1794S|FREM1_ENST00000486223.1_5'UTR			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1794	Calx-beta.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGTTTAGATGGAATCACGGTG	0.333000													5	10					0	0	1	0	0
SH3GL3	6457	broad.mit.edu	37	15	84237342	84237342	+	Silent	SNP	C	C	T	rs146975595		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84237342C>T	ENST00000324537.5	+	7	765	c.273C>T	c.(271-273)acC>acT	p.T91T	SH3GL3_ENST00000427482.2_Silent_p.T83T|SH3GL3_ENST00000535412.1_Silent_p.T83T|SH3GL3_ENST00000434347.1_Silent_p.T91T			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	83	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						AGGTGAAGACCACAGGATACC	0.468000													28	125					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8530211	8530211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8530211C>T	ENST00000348943.3	+	6	674	c.442C>T	c.(442-444)Cct>Tct	p.P148S	HNRNPM_ENST00000325495.4_Missense_Mutation_p.P148S	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	148	RRM 1.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						GTTTTAGGATCCTGATGGTGA	0.458000													17	176					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51749831	51749831	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51749831C>A	ENST00000395052.3	+	4	2276	c.2042C>A	c.(2041-2043)gCc>gAc	p.A681D	GRM2_ENST00000442933.2_Intron|GRM2_ENST00000475478.1_3'UTR	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	681					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TCACAGGTGGCCATCTGCCTG	0.672000													9	40					0.00829132	0.00829502	1	1	0
SLC38A1	81539	broad.mit.edu	37	12	46598182	46598182	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:46598182G>A	ENST00000398637.5	-	11	1418	c.724C>T	c.(724-726)Caa>Taa	p.Q242*	SLC38A1_ENST00000552197.1_Nonsense_Mutation_p.Q242*|SLC38A1_ENST00000549049.1_Nonsense_Mutation_p.Q242*|SLC38A1_ENST00000439706.1_Nonsense_Mutation_p.Q242*|SLC38A1_ENST00000549633.1_5'UTR|SLC38A1_ENST00000546893.1_Nonsense_Mutation_p.Q242*	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	242					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			CAGGGAATTTGAAATTTCTTG	0.323000													14	136					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095218	167095218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167095218G>A	ENST00000361200.2	+	6	1016	c.850G>A	c.(850-852)Gag>Aag	p.E284K	DUSP27_ENST00000271385.5_Missense_Mutation_p.E284K|DUSP27_ENST00000443333.1_Missense_Mutation_p.E284K|DUSP27_ENST00000485151.1_3'UTR			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	284					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity	p.E284Q(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GGAGAGAGAAGAGGACTATGG	0.617000													11	50					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26108068	26108068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26108068G>A	ENST00000313735.6	-	8	1091	c.858C>T	c.(856-858)ttC>ttT	p.F286F		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	286					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GTACCTGAGTGAATTCCACGT	0.647000													18	38					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043908	56043908	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56043908G>A	ENST00000313033.2	+	1	880	c.794G>A	c.(793-795)gGg>gAg	p.G265E		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					ATTTATCATGGGACAATCCTC	0.413000													65	160					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107646739	107646739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107646739G>A	ENST00000374736.3	-	4	665	c.271C>T	c.(271-273)Ccc>Tcc	p.P91S	ABCA1_ENST00000423487.2_Missense_Mutation_p.P91S|ABCA1_ENST00000374733.1_Missense_Mutation_p.P31S	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	91					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACAACTCCGGGAGCCTCCCCA	0.453000													18	61					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178879114	178879114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:178879114C>T	ENST00000286063.5	-	2	1303	c.986G>A	c.(985-987)cGa>cAa	p.R329Q	PDE11A_ENST00000358450.4_Missense_Mutation_p.R79Q	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	329	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			ATCACTGCTTCGGATAGGCAT	0.373000									Primary Pigmented Nodular Adrenocortical Disease, Familial				26	103					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170663	207170663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207170663G>A	ENST00000374423.3	+	5	1797	c.1411G>A	c.(1411-1413)Gaa>Aaa	p.E471K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	471							nucleic acid binding|zinc ion binding	p.E471*(2)		endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GATTGTTAAAGAAATAAGTCT	0.333000													12	28					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3319150	3319150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3319150C>T	ENST00000336727.3	+	2	2157	c.1253C>T	c.(1252-1254)aCc>aTc	p.T418I	RGS12_ENST00000344733.5_Missense_Mutation_p.T418I|RGS12_ENST00000543385.1_Missense_Mutation_p.T418I|RGS12_ENST00000382788.3_Missense_Mutation_p.T418I	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	418						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AACAACAGCACCAGCAGCAAC	0.617000													31	74					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48695053	48695053	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:48695053G>A	ENST00000236495.5	+	5	551	c.501G>A	c.(499-501)aaG>aaA	p.K167K	SLC5A9_ENST00000533824.1_Silent_p.K163K|RP5-1024N4.4_ENST00000606809.1_RNA|SLC5A9_ENST00000420136.2_Silent_p.K135K|SLC5A9_ENST00000438567.2_Silent_p.K142K	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	142						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						AGTATCTGAAGAAGCGATTTG	0.562000													10	81					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22806109	22806109	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:22806109G>A	ENST00000361524.3	-	4	1921	c.1773C>T	c.(1771-1773)gcC>gcT	p.A591A	ZNF521_ENST00000584787.1_Silent_p.A371A|ZNF521_ENST00000538137.2_Silent_p.A591A	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	591					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TATAATTCAGGGCCAAGGGAA	0.413000			T	PAX5	ALL								26	55					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182108	140182108	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140182108C>T	ENST00000522353.2	+	1	1326	c.1326C>T	c.(1324-1326)tcC>tcT	p.S442S	PCDHA3_ENST00000532566.2_Silent_p.S442S|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGCGTGTCCGTGGAGGTGG	0.652000													61	133					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156269026	156269026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156269026C>T	ENST00000311277.4	-	14	2116	c.1853G>A	c.(1852-1854)cGa>cAa	p.R618Q	MAP9_ENST00000515654.1_Missense_Mutation_p.R594Q|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000597939.1_RNA|AC097467.2_ENST00000595229.1_RNA|AC097467.2_ENST00000601977.1_RNA|AC097467.2_ENST00000593387.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	618					cell division|mitosis	cytoplasm|microtubule|spindle		p.R618Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CTTCTGTTTTCGTTCAATTCT	0.338000													3	10					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58342389	58342389	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58342389C>T	ENST00000371015.1	+	5	1157	c.690C>T	c.(688-690)agC>agT	p.S230S	PHACTR3_ENST00000541461.1_Silent_p.S189S|PHACTR3_ENST00000395636.2_Silent_p.S189S|PHACTR3_ENST00000395639.4_Intron|PHACTR3_ENST00000361300.4_Intron|PHACTR3_ENST00000355648.4_Silent_p.S189S|PHACTR3_ENST00000359926.3_Silent_p.S227S	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	230	Pro-rich.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			AGCTCCCCAGCCCCCCACTGC	0.592000													19	38					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711110	20711110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20711110G>A	ENST00000315409.2	+	1	213	c.160G>A	c.(160-162)Gcc>Acc	p.A54T		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A54S(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		GGGAAATGGAGCCATCATCTA	0.448000													32	86					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22134064	22134064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22134064C>T	ENST00000408935.1	+	1	768	c.768C>T	c.(766-768)ttC>ttT	p.F256F		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CATGTATCTTCATCTATACTC	0.507000													20	46					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12343364	12343364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12343364C>T	ENST00000358136.3	+	21	5335	c.5205C>T	c.(5203-5205)gtC>gtT	p.V1735V	VPS13D_ENST00000356315.4_Silent_p.V1735V	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1735					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CTCCTAATGTCTTCCAGTTGT	0.493000													20	70					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55285069	55285069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55285069G>A	ENST00000336077.6	+	3	395	c.355G>A	c.(355-357)Gac>Aac	p.D119N	KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL1_ENST00000291633.7_Missense_Mutation_p.D119N|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	119					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		TGACCCTCTGGACATCGTGAT	0.522000													106	297					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47241497	47241497	+	Missense_Mutation	SNP	C	C	T	rs145043273		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47241497C>T	ENST00000300404.2	+	8	1053	c.994C>T	c.(994-996)Cgc>Tgc	p.R332C	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.R246C|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.R272C	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	332					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GACTTTCCTCCGCCCCCACAA	0.502000													43	193					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15601415	15601415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:15601415G>A	ENST00000281513.5	-	21	2274	c.2249C>T	c.(2248-2250)tCc>tTc	p.S750F	NBAS_ENST00000441750.1_Missense_Mutation_p.S750F	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	750										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						AAGCAGGTCGGAACCATGGTA	0.418000													20	90					0	0	1	0	0
SCN4B	6330	broad.mit.edu	37	11	118015844	118015844	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118015844G>A	ENST00000324727.4	-	2	308	c.162C>T	c.(160-162)acC>acT	p.T54T	SCN4B_ENST00000529878.1_Intron	NM_001142349.1|NM_174934.3	NP_001135821.1|NP_777594.1	Q8IWT1	SCN4B_HUMAN	sodium channel, voltage-gated, type IV, beta subunit	54	Ig-like C2-type.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.33e-05)|Epithelial(105;0.00126)		AGCTGGAGAAGGTGCAGGGCA	0.557000											OREG0021380	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	146					0	0	1	0	0
ZC3H6	376940	broad.mit.edu	37	2	113089137	113089137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113089137C>T	ENST00000409871.1	+	12	3043	c.2642C>T	c.(2641-2643)cCc>cTc	p.P881L	ZC3H6_ENST00000343936.4_Missense_Mutation_p.P881L	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	881							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						GTGTGGGCTCCCGAAGACTTA	0.428000													12	33					0	0	1	0	0
IL18BP	10068	broad.mit.edu	37	11	71711488	71711488	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71711488C>T	ENST00000497194.2	+	2	1492	c.120C>T	c.(118-120)gcC>gcT	p.A40A	IL18BP_ENST00000531053.1_Silent_p.A40A|IL18BP_ENST00000337131.5_Silent_p.A40A|IL18BP_ENST00000393703.4_Silent_p.A40A|IL18BP_ENST00000393705.4_Silent_p.A40A|IL18BP_ENST00000404792.1_Silent_p.A40A|IL18BP_ENST00000393707.4_Silent_p.A40A|IL18BP_ENST00000260049.5_Silent_p.A40A			O95998	I18BP_HUMAN	interleukin 18 binding protein	40					T-helper 1 type immune response	extracellular region	interleukin-18 binding|receptor antagonist activity	p.A40A(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(1)	7						CCACAGCTGCCACTGCCTCAG	0.607000													35	101					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176812784	176812784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176812784C>T	ENST00000324417.5	+	2	133	c.42C>T	c.(40-42)tcC>tcT	p.S14S	SLC34A1_ENST00000512593.1_Silent_p.S14S	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	14					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGCTGTCTCCCCACTCCCAG	0.622000													6	19					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1212541	1212541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1212541C>T	ENST00000304460.10	+	4	661	c.605C>T	c.(604-606)gCc>gTc	p.A202V		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	202					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTGTGCCTGGCCTGCGCATGG	0.637000													13	145					0	0	1	0	0
SH2B2	10603	broad.mit.edu	37	7	101957774	101957774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101957774C>T	ENST00000536178.1	+	8	1463	c.1418C>T	c.(1417-1419)cCc>cTc	p.P473L	SH2B2_ENST00000306803.8_Missense_Mutation_p.P435L			O14492	SH2B2_HUMAN	SH2B adaptor protein 2	436	SH2.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	9						GCAGGGGGGCCCCGGAACCAC	0.627000													11	19					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48746744	48746744	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48746744G>A	ENST00000285238.8	+	17	2176	c.2096G>A	c.(2095-2097)tGg>tAg	p.W699*		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	699	ABC transporter 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CAGCAGGCATGGATCCAGAAC	0.612000													23	64					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342997	29342997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29342997G>A	ENST00000396806.3	-	1	71	c.68C>T	c.(67-69)cCt>cTt	p.P23L	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						AAAGAAGAAAGGCTGCAGCTC	0.393000													8	61					0	0	1	0	0
ALOX15	246	broad.mit.edu	37	17	4536769	4536769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4536769G>A	ENST00000570836.1	-	10	1284	c.1188C>T	c.(1186-1188)acC>acT	p.T396T	ALOX15_ENST00000293761.3_Silent_p.T396T|ALOX15_ENST00000574640.1_Silent_p.T357T|ALOX15_ENST00000545513.1_Silent_p.T418T			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	396	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	TAATTTCCAGGGTGTATCGCA	0.517000													32	27					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833569	168833569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168833569G>A	ENST00000464456.1	-	7	2727	c.1527C>T	c.(1525-1527)ctC>ctT	p.L509L	MECOM_ENST00000433243.2_Silent_p.L510L|MECOM_ENST00000460814.1_Silent_p.L509L|MECOM_ENST00000392736.3_Silent_p.L509L|MECOM_ENST00000472280.1_Silent_p.L510L|MECOM_ENST00000264674.3_Silent_p.L574L|MECOM_ENST00000468789.1_Silent_p.L509L|MECOM_ENST00000494292.1_Silent_p.L697L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GAAAAAATGGGAGGGGAAACA	0.418000													37	85					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	280286	280286	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:280286G>A	ENST00000538872.1	+	13	3191	c.3073G>A	c.(3073-3075)Gaa>Aaa	p.E1025K	RP11-598F7.6_ENST00000537295.1_lincRNA|IQSEC3_ENST00000537151.1_3'UTR|IQSEC3_ENST00000382841.2_Missense_Mutation_p.E722K|IQSEC3_ENST00000326261.4_Missense_Mutation_p.E1025K			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	1025					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		AGCCAAAAGGGAAGCCGCGCT	0.617000													16	59					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189068247	189068247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189068247C>T	ENST00000332517.3	+	6	1268	c.1128C>T	c.(1126-1128)ttC>ttT	p.F376F	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	376	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GGGACCTGTTCTCACTAATAG	0.527000													21	111					0	0	1	0	0
DEFB115	245929	broad.mit.edu	37	20	29847325	29847325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:29847325G>A	ENST00000400552.1	+	2	157	c.157G>A	c.(157-159)Gag>Aag	p.E53K		NM_001037730.1	NP_001032819.1	Q30KQ5	DB115_HUMAN	defensin, beta 115	53					defense response to bacterium	extracellular region				kidney(1)|lung(3)|ovary(1)|skin(1)	6			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			CAAAGAAATTGAGAGGAAGAA	0.353000													17	39					0	0	1	0	0
DPF2	5977	broad.mit.edu	37	11	65107856	65107856	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65107856C>T	ENST00000528416.1	+	2	166	c.32_splice	c.e2-1	p.L11_splice	DPF2_ENST00000252268.4_Splice_Site_p.L11_splice|DPF2_ENST00000415073.2_Splice_Site_p.L11_splice|DPF2_ENST00000532264.1_Intron	NM_006268.4	NP_006259.1	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	11					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)	23						TTCCCTGCAGCCTTGGGGAGC	0.557000													48	232					0	0	1	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118005533	118005533	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:118005533C>T	ENST00000310754.4	-	1	1203	c.1017G>A	c.(1015-1017)tcG>tcA	p.S339S		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	339					protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						TAGAAGATCTCGACCGTTTCT	0.403000													81	169					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255182	140255182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140255182G>A	ENST00000398631.2	+	1	125	c.125G>A	c.(124-126)gGc>gAc	p.G42D	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAAACACGGCACCTTCGTG	0.677000													29	95					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74489273	74489273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74489273C>T	ENST00000394019.2	-	11	1199	c.802G>A	c.(802-804)Gga>Aga	p.G268R	SLC4A5_ENST00000346834.4_Missense_Mutation_p.G268R|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Missense_Mutation_p.G268R|SLC4A5_ENST00000377634.4_Missense_Mutation_p.G268R|SLC4A5_ENST00000359484.4_Missense_Mutation_p.G204R|SLC4A5_ENST00000357822.5_Missense_Mutation_p.G268R|SLC4A5_ENST00000358683.4_Missense_Mutation_p.G204R|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Missense_Mutation_p.G268R	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	268						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CACAGACGTCCGTAATTTGCA	0.597000													7	42					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27169583	27169583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27169583G>A	ENST00000380036.4	+	4	1026	c.584G>A	c.(583-585)gGa>gAa	p.G195E	TEK_ENST00000519097.1_Missense_Mutation_p.G91E|TEK_ENST00000406359.4_Missense_Mutation_p.G195E	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	195					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AGGTATATAGGAGGAAACCTC	0.507000													41	88					0	0	1	0	0
RAD9A	5883	broad.mit.edu	37	11	67161231	67161231	+	Missense_Mutation	SNP	C	C	T	rs144155838	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67161231C>T	ENST00000307980.2	+	5	512	c.419C>T	c.(418-420)tCg>tTg	p.S140L		NM_001243224.1|NM_004584.2	NP_001230153.1|NP_004575.1	Q99638	RAD9A_HUMAN	RAD9 homolog A (S. pombe)	140					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding			lung(7)|upper_aerodigestive_tract(1)	8			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GACCCAGCCTCGTGCCCCCAC	0.657000								Other conserved DNA damage response genes					7	14					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994727	140994727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140994727C>T	ENST00000285879.4	+	4	1823	c.1537C>T	c.(1537-1539)Cct>Tct	p.P513S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	513							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCCAGTCTCCTCTCCAGAT	0.507000										HNSCC(15;0.026)			119	83					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215831647	215831647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215831647G>A	ENST00000272895.7	-	39	6028	c.5809C>T	c.(5809-5811)Ctt>Ttt	p.L1937F	ABCA12_ENST00000389661.4_Missense_Mutation_p.L1619F	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1937					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TAAGCTGGAAGGGAGTGATAG	0.383000													32	62					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48628106	48628106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48628106C>T	ENST00000006658.6	+	11	1331	c.1211C>T	c.(1210-1212)cCc>cTc	p.P404L	SPATA20_ENST00000511937.1_3'UTR|SPATA20_ENST00000393244.3_Missense_Mutation_p.P344L|SPATA20_ENST00000356488.4_Missense_Mutation_p.P388L	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	388					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			GCAGACTCGCCCCCAGAGCGG	0.672000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	103					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38481797	38481797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38481797G>A	ENST00000263409.4	-	20	3356	c.3194C>T	c.(3193-3195)tCc>tTc	p.S1065F	LIFR_ENST00000453190.2_Missense_Mutation_p.S1065F	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	1065					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					AAATTGTCGGGAATTAATGGA	0.388000			T	PLAG1	salivary adenoma								58	156					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30705246	30705246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30705246C>T	ENST00000256246.2	-	1	1362	c.1288G>A	c.(1288-1290)Gaa>Aaa	p.E430K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	430										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GACACTGGTTCATTTTCATTT	0.338000													43	157					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10788473	10788473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10788473G>A	ENST00000283025.2	-	1	329	c.258C>T	c.(256-258)ttC>ttT	p.F86F		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	86					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						TATAGCGAGAGAAGAGTGCGG	0.667000													31	65					0	0	1	0	0
SCARF2	91179	broad.mit.edu	37	22	20780149	20780149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20780149G>A	ENST00000405555.3	-	11	2184	c.2114C>T	c.(2113-2115)tCg>tTg	p.S705L	SCARF2_ENST00000266214.5_Missense_Mutation_p.S710L	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	705	Pro-rich.				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGTATGCGCCGATTTGTCGCT	0.766000													9	13					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3678588	3678588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3678588G>A	ENST00000344754.4	-	8	1978	c.1979C>T	c.(1978-1980)tCc>tTc	p.S660F	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.S660F	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	660	Ig-like C2-type 6.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CATGCGTGGGGAACAGCCCCC	0.622000													32	74					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750359	142750359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142750359G>A	ENST00000418316.1	+	1	943	c.922G>A	c.(922-924)Ggc>Agc	p.G308S		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					GAGGCTGAAAGGCCTTTGCAA	0.542000													10	20					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173873345	173873345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:173873345C>T	ENST00000506823.1	+	10	1964	c.1307C>T	c.(1306-1308)gCt>gTt	p.A436V	GALNTL6_ENST00000508122.1_Missense_Mutation_p.A419V	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	436						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						TTCATGGCTGCTGTGGCCTGG	0.612000													13	36					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17895037	17895037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17895037G>A	ENST00000594202.1	+	25	2498	c.2219G>A	c.(2218-2220)cGa>cAa	p.R740Q	FCHO1_ENST00000600676.1_Missense_Mutation_p.R740Q|FCHO1_ENST00000597512.1_Missense_Mutation_p.R747Q|FCHO1_ENST00000252771.7_Missense_Mutation_p.R740Q|FCHO1_ENST00000595033.1_Missense_Mutation_p.R690Q|FCHO1_ENST00000596951.1_Missense_Mutation_p.R740Q|FCHO1_ENST00000596536.1_Missense_Mutation_p.R740Q|FCHO1_ENST00000539407.1_Missense_Mutation_p.R740Q|FCHO1_ENST00000389133.4_Missense_Mutation_p.R740Q	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	740										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						GTGCTGCTGCGATACCAGGTG	0.657000											OREG0025350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	8					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887209	47887209	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47887209G>A	ENST00000396105.1	-	3	1386	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F	ZNFX1_ENST00000371752.1_Silent_p.F380F|ZNFX1_ENST00000371754.4_Silent_p.F380F	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	380							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AAGGTCTGACGAAATCTTCTC	0.468000													40	83					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3677847	3677847	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3677847G>A	ENST00000344754.4	-	9	2264	c.2265C>T	c.(2263-2265)ccC>ccT	p.P755P	SIGLEC1_ENST00000202578.4_Silent_p.P755P	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	755	Ig-like C2-type 7.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CGGTCTCCAGGGGACCCTGGG	0.632000													24	58					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119036026	119036026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119036026C>T	ENST00000296499.5	+	4	1538	c.1135C>T	c.(1135-1137)Cct>Tct	p.P379S	NDST3_ENST00000433996.2_Intron	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	379	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						CTGGTGGTTTCCTCACATGTG	0.443000													23	72					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41525800	41525800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41525800G>A	ENST00000396942.1	-	39	5462	c.5379C>T	c.(5377-5379)ttC>ttT	p.F1793F	ANK1_ENST00000352337.4_Silent_p.F1793F|ANK1_ENST00000396945.1_Silent_p.F1793F|ANK1_ENST00000289734.7_Silent_p.F1793F|ANK1_ENST00000379758.2_Silent_p.F1793F|ANK1_ENST00000265709.8_Silent_p.F1834F|ANK1_ENST00000347528.4_Silent_p.F1793F			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1793	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCACTTGGGTGAAGGTGTTCT	0.652000													33	49					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158326659	158326659	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158326659G>A	ENST00000444681.2	+	5	1136	c.843G>A	c.(841-843)tgG>tgA	p.W281*	CD1E_ENST00000368161.3_3'UTR|CD1E_ENST00000368166.3_Nonsense_Mutation_p.W179*|CD1E_ENST00000452291.2_Nonsense_Mutation_p.W191*|CD1E_ENST00000368167.3_Nonsense_Mutation_p.W380*|CD1E_ENST00000368163.3_Nonsense_Mutation_p.W313*|CD1E_ENST00000368155.3_Nonsense_Mutation_p.W223*|CD1E_ENST00000368160.3_Nonsense_Mutation_p.W368*|CD1E_ENST00000368156.1_Nonsense_Mutation_p.W278*|CD1E_ENST00000368157.1_Nonsense_Mutation_p.W124*|CD1E_ENST00000368154.1_Nonsense_Mutation_p.W136*|CD1E_ENST00000368164.3_3'UTR|CD1E_ENST00000368165.3_Nonsense_Mutation_p.W290*	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	380	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen		p.W380*(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					TGAAGAAGTGGAAGACACGCC	0.428000													26	116					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128494141	128494141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128494141G>A	ENST00000325888.8	+	40	6859	c.6598G>A	c.(6598-6600)Gag>Aag	p.E2200K	FLNC_ENST00000346177.6_Missense_Mutation_p.E2167K|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2200	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GCGGGGCGGGGAGACAAAGCG	0.687000													6	25					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53104213	53104213	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:53104213C>T	ENST00000408890.4	+	1	865	c.849C>T	c.(847-849)ttC>ttT	p.F283F		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	283								p.F283L(1)		endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GGGTCTCCTTCGCCCTCGAGG	0.617000													25	66					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81648080	81648080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81648080C>T	ENST00000558726.1	-	9	1056	c.921G>A	c.(919-921)aaG>aaA	p.K307K	RP11-761I4.3_ENST00000559781.1_RNA|RP11-761I4.3_ENST00000560851.1_RNA|TMC3_ENST00000359440.5_Silent_p.K307K			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	307						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						TTTTGCTTTTCTTTTTCTCCT	0.269000													13	63					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12943017	12943017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12943017G>A	ENST00000235349.5	-	2	269	c.199C>T	c.(199-201)Cct>Tct	p.P67S		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	67										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCTCAGAGGGAGGCGGCGG	0.602000													26	79					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222682	140222682	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140222682G>A	ENST00000531613.1	+	1	1776	c.1776G>A	c.(1774-1776)gcG>gcA	p.A592A	PCDHA8_ENST00000378123.3_Silent_p.A592A|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTGGTAGCGAAGGTGCGCG	0.697000													24	24					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39382857	39382857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39382857G>A	ENST00000545653.1	-	9	1671	c.1141C>T	c.(1141-1143)Cct>Tct	p.P381S	DAB2_ENST00000509337.1_Missense_Mutation_p.P381S|DAB2_ENST00000320816.6_Missense_Mutation_p.P402S|DAB2_ENST00000339788.6_Intron	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	402					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			CCTTTGGGAGGGCTTCCCACA	0.507000													29	87					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129744079	129744079	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:129744079G>A	ENST00000446488.3	-	20	2311	c.2208C>T	c.(2206-2208)tcC>tcT	p.S736S	NFRKB_ENST00000524794.1_Silent_p.S761S|NFRKB_ENST00000524746.1_Silent_p.S736S|NFRKB_ENST00000304521.5_Silent_p.S736S	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	736	Pro-rich.|Ser-rich.				DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		CAGGTGGAGGGGAGATGGGAA	0.557000													28	83					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150530026	150530026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150530026G>A	ENST00000271643.4	+	13	2340	c.2104G>A	c.(2104-2106)Gaa>Aaa	p.E702K	ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.E702K|ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.E702K|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.E725K|RP11-54A4.2_ENST00000442435.2_RNA	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	702					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GGAACTGGATGAACGCAGCTG	0.672000													5	8					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10315990	10315990	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10315990G>A	ENST00000403437.2	-	13	1297	c.1203C>T	c.(1201-1203)gcC>gcT	p.A401A	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	401	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GGTAGCAGAGGGCTTTGAGTA	0.498000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				94	133					0	0	1	0	0
CXorf27	25763	broad.mit.edu	37	X	37850185	37850185	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37850185C>T	ENST00000341016.3	+	1	116	c.93C>T	c.(91-93)ttC>ttT	p.F31F	TM4SF2_ENST00000465127.1_Intron	NM_012274.1	NP_036406.1	O75409	HYPM_HUMAN	chromosome X open reading frame 27	31							DNA binding			central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(2)	8						CTAGGAGCTTCGTGGACCGCG	0.458000													5	28					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163513	32163513	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32163513G>A	ENST00000564145.1	-	0	65																											CCTTCGGGGTGATGCCAGTCA	0.547000													18	72					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103051925	103051925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103051925C>T	ENST00000306312.3	-	6	773	c.512G>A	c.(511-513)aGa>aAa	p.R171K	SLC26A5_ENST00000393723.1_Missense_Mutation_p.R171K|SLC26A5_ENST00000393727.1_Missense_Mutation_p.R171K|SLC26A5_ENST00000393729.1_Missense_Mutation_p.R134K|SLC26A5_ENST00000393730.1_Missense_Mutation_p.R171K|SLC26A5_ENST00000393735.2_Missense_Mutation_p.R171K|SLC26A5_ENST00000356767.4_Missense_Mutation_p.R171K|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000339444.6_Missense_Mutation_p.R171K|SLC26A5_ENST00000432958.2_Missense_Mutation_p.R171K	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	171					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CAAGGCATCTCTGGCCTCTGT	0.448000													24	78					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908168	103908168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103908168G>A	ENST00000302259.3	+	1	861	c.618G>A	c.(616-618)ctG>ctA	p.L206L	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	206					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CCGACCCACTGGATCGGGAAG	0.507000													21	91					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2229538	2229538	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2229538C>T	ENST00000399655.1	+	3	684	c.419C>T	c.(418-420)gCc>gTc	p.A140V	CACNA1C_ENST00000399637.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000480911.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000335762.5_Missense_Mutation_p.A140V|CACNA1C_ENST00000399603.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399649.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399595.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399606.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399601.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399617.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000344100.3_Missense_Mutation_p.A140V|CACNA1C_ENST00000399621.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399629.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000327702.7_Missense_Mutation_p.A140V|CACNA1C_ENST00000406454.3_Missense_Mutation_p.A140V|CACNA1C_ENST00000402845.3_Missense_Mutation_p.A140V|CACNA1C_ENST00000399597.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000347598.4_Missense_Mutation_p.A140V|CACNA1C_ENST00000399641.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399638.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399644.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399591.1_Missense_Mutation_p.A140V|CACNA1C_ENST00000399634.1_Missense_Mutation_p.A140V	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	140					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AATTGTGTGGCCTTAGCGATC	0.403000													29	115					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46338424	46338424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46338424G>A	ENST00000245934.7	-	11	1549	c.1305C>T	c.(1303-1305)acC>acT	p.T435T		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	435					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		ACTCCACGGGGGTGTAGATGG	0.607000													23	83					0	0	1	0	0
C22orf43	51233	broad.mit.edu	37	22	23974157	23974157	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23974157C>T	ENST00000317749.5	-	1	351	c.54G>A	c.(52-54)ggG>ggA	p.G18G	AP000346.2_ENST00000390329.2_RNA	NM_016449.3	NP_057533.2	Q6PGQ1	CV043_HUMAN	chromosome 22 open reading frame 43	18										endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						GTGCGTCCTTCCCCCTGGGCC	0.527000													18	81					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10363550	10363550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10363550C>T	ENST00000255381.2	-	13	1346	c.1236G>A	c.(1234-1236)gaG>gaA	p.E412E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	412	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TGGTTACGAACTCATTGCCGA	0.438000													46	54					0	0	1	0	0
CXCL10	3627	broad.mit.edu	37	4	76943088	76943088	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76943088G>A	ENST00000306602.1	-	4	357	c.292C>T	c.(292-294)Cct>Tct	p.P98S	ART3_ENST00000341029.5_Intron	NM_001565.3	NP_001556.2	P02778	CXL10_HUMAN	chemokine (C-X-C motif) ligand 10	98					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity			kidney(1)|large_intestine(1)|lung(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGGTTTTAAGGAGATCTTTTA	0.453000													50	128					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80772140	80772140	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:80772140G>A	ENST00000466387.1	+	14	2048	c.1324G>A	c.(1324-1326)Gaa>Aaa	p.E442K	CTNNA2_ENST00000540488.1_Missense_Mutation_p.E442K|CTNNA2_ENST00000496558.1_Missense_Mutation_p.E442K|CTNNA2_ENST00000402739.4_Missense_Mutation_p.E442K|CTNNA2_ENST00000343114.3_Missense_Mutation_p.E121K|CTNNA2_ENST00000361291.4_Missense_Mutation_p.E476K|CTNNA2_ENST00000541047.1_Missense_Mutation_p.E442K			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	442					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CTCCAACAATGAAGAAGGGGT	0.468000													11	44					0	0	1	0	0
HPR	3250	broad.mit.edu	37	16	72110569	72110569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72110569G>A	ENST00000540303.2	+	5	668	c.636G>A	c.(634-636)aaG>aaA	p.K212K	HPR_ENST00000228226.8_Silent_p.K249K|HPR_ENST00000561690.1_Intron|HPR_ENST00000356967.5_Silent_p.K212K	NM_020995.3	NP_066275.3	P00739	HPTR_HUMAN	haptoglobin-related protein	212	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|stomach(1)|urinary_tract(2)	20		Ovarian(137;0.125)				TACCTTCAAAGAATTATGCAG	0.458000													39	87					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41298734	41298734	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:41298734T>G	ENST00000347132.5	+	11	1644	c.1562T>G	c.(1561-1563)cTc>cGc	p.L521R	KCNQ4_ENST00000509682.2_Missense_Mutation_p.L467R|KCNQ4_ENST00000506017.1_3'UTR	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	521					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			CAGTGTGAGCTCACGGTGGAC	0.602000													14	65					0	0	1	0	0
IGHA2	3494	broad.mit.edu	37	14	106054664	106054664	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106054664G>A	ENST00000390539.2	-	0	68																											GGCATGCGACGACCACGTTCC	0.637000													20	46					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85432029	85432029	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:85432029A>C	ENST00000393217.2	+	2	136	c.75A>C	c.(73-75)gaA>gaC	p.E25D		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	25										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CCTCCTTGGAAAAAGAAGACA	0.373000													11	97					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103701746	103701746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:103701746G>A	ENST00000245312.3	-	5	1408	c.812C>T	c.(811-813)tCc>tTc	p.S271F		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	271					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AACGATGGTGGAACATAGCTG	0.463000													23	72					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120903838	120903838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120903838C>T	ENST00000263713.5	+	20	1980	c.1766C>T	c.(1765-1767)gCc>gTc	p.A589V	EPB41L5_ENST00000443902.2_Missense_Mutation_p.A589V|EPB41L5_ENST00000452780.1_Missense_Mutation_p.A589V	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	589						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						CATAAAAATGCCAATGTTCAG	0.294000													14	28					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97078439	97078439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:97078439C>T	ENST00000524981.3	+	8	1083	c.1083C>T	c.(1081-1083)gcC>gcT	p.A361A				Q6ZTY8	CL063_HUMAN		335										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						TTCTCCAAGCCAGCAATCAAA	0.308000													7	105					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202900660	202900660	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202900660C>T	ENST00000286201.1	+	1	1351	c.1290C>T	c.(1288-1290)ttC>ttT	p.F430F		NM_003507.1	NP_003498.1	O75084	FZD7_HUMAN	frizzled family receptor 7	430					axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						CGCCTCTGTTCGTCTACCTCT	0.627000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	99					0	0	1	0	0
TBCCD1	55171	broad.mit.edu	37	3	186274254	186274254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186274254G>A	ENST00000424280.1	-	4	1282	c.803C>T	c.(802-804)cCa>cTa	p.P268L	TBCCD1_ENST00000338733.5_Missense_Mutation_p.P268L|TBCCD1_ENST00000446782.1_Missense_Mutation_p.P172L	NM_001134415.1	NP_001127887.1	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	268					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		TGTACCAAATGGATTCCCAGT	0.388000													31	61					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53012265	53012265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53012265C>T	ENST00000305748.3	-	1	78	c.44G>A	c.(43-45)gGg>gAg	p.G15E		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	15	Gly-rich.|Head.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTGAAGCCCCCCTTGGCAGC	0.612000													21	80					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233353658	233353658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233353658G>A	ENST00000258229.8	-	12	2912	c.2678C>T	c.(2677-2679)gCc>gTc	p.A893V	PCNXL2_ENST00000488780.2_Missense_Mutation_p.A26V|PCNXL2_ENST00000430153.1_Missense_Mutation_p.A192V	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	893						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TATTGGTGAGGCGGGGTCAGG	0.438000													5	34					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192701045	192701045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:192701045G>A	ENST00000304141.4	-	2	1211	c.882C>T	c.(880-882)ccC>ccT	p.P294P		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	294						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CGAAAGTGAGGGGAGAAACCT	0.473000													61	180					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108626548	108626548	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108626548C>T	ENST00000332082.4	+	8	1838	c.1020C>T	c.(1018-1020)tcC>tcT	p.S340S	WSCD2_ENST00000547525.1_Silent_p.S340S|WSCD2_ENST00000261400.3_Silent_p.S340S|WSCD2_ENST00000549903.1_Silent_p.S340S			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	340						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						CAGGCAAGTCCAAGCAGCTCA	0.562000													13	30					0	0	1	0	0
FBXL18	80028	broad.mit.edu	37	7	5529693	5529693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5529693G>A	ENST00000453700.3	-	5	2268	c.2151C>T	c.(2149-2151)gtC>gtT	p.V717V	FBXL18_ENST00000382368.3_Intron			Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	717									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		TTATTCCTGAGACAGCCAGCG	0.493000													5	8					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50253064	50253064	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50253064C>T	ENST00000420502.1	+	0	615							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	TCCAGAACATCGGAGGTAAGA	0.657000													5	55					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56545017	56545017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56545017G>A	ENST00000390649.3	+	9	2557	c.2557G>A	c.(2557-2559)Gat>Aat	p.D853N		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	853						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GAAGGAAGAGGATGTAAGGAT	0.483000													74	199					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75983031	75983031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75983031G>A	ENST00000308508.5	-	3	467	c.375C>T	c.(373-375)gtC>gtT	p.V125V		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	125	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GAAACCCATCGACTGACAACG	0.627000													39	101					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24432489	24432489	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24432489G>A	ENST00000330966.7	-	5	646	c.484C>T	c.(484-486)Cgc>Tgc	p.R162C	MYOM3_ENST00000374434.3_Missense_Mutation_p.R161C|MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Missense_Mutation_p.R161C			Q5VTT5	MYOM3_HUMAN	myomesin 3	161	Ig-like C2-type 1.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCGTGGGAGCGAAGAGGGATC	0.657000													6	62					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764252	92764252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92764252C>T	ENST00000318238.4	-	5	2249	c.1033G>A	c.(1033-1035)Gaa>Aaa	p.E345K	SAMD9L_ENST00000411955.1_Missense_Mutation_p.E345K|SAMD9L_ENST00000437805.1_Missense_Mutation_p.E345K	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	345										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CTAGCCCCTTCTCTTACAAAC	0.333000													56	119					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145111140	145111140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145111140C>T	ENST00000426825.1	-	15	2087	c.2006G>A	c.(2005-2007)gGg>gAg	p.G669E	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	669							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CTGGTAGCCCCCCTCAAAGTA	0.637000													18	59					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49063860	49063860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:49063860G>A	ENST00000226432.4	+	16	2236	c.2053G>A	c.(2053-2055)Gaa>Aaa	p.E685K	CWH43_ENST00000513409.1_Missense_Mutation_p.E658K	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	685					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						ACACAATTATGAAAACAACCA	0.259000													20	39					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69961741	69961741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:69961741G>A	ENST00000358913.5	+	18	4137	c.3649G>A	c.(3649-3651)Gag>Aag	p.E1217K	MYPN_ENST00000354393.2_Missense_Mutation_p.E942K|MYPN_ENST00000540630.1_Missense_Mutation_p.E1217K	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	1217	Ig-like 5.|Interaction with ACTN.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						TTGCACCAGAGAGAGGATCAG	0.567000													45	108					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48654502	48654502	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48654502G>A	ENST00000263274.7	-	7	980	c.561C>T	c.(559-561)ccC>ccT	p.P187P	LIG1_ENST00000536218.1_Intron|LIG1_ENST00000599165.1_5'UTR|LIG1_ENST00000427526.2_Silent_p.P156P	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	187					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	AGGTCTTTAGGGGCTTGGGAG	0.557000								Nucleotide excision repair (NER)					40	157					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153497395	153497395	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:153497395G>A	ENST00000288670.9	+	25	3503	c.3136G>A	c.(3136-3138)Gga>Aga	p.G1046R	FMNL2_ENST00000475377.2_Missense_Mutation_p.G421R	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	1046	DAD.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						TGTATATGAGGGAAAAGATGG	0.413000													12	42					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955846	51955846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51955846C>T	ENST00000321424.3	-	7	1353	c.1287G>A	c.(1285-1287)aaG>aaA	p.K429K	SIGLEC8_ENST00000430817.1_Silent_p.K320K|SIGLEC8_ENST00000340550.5_Silent_p.K336K	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	429					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GGGGAGGCTTCTTCAGGGGGT	0.592000													8	51					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85450471	85450471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:85450471G>A	ENST00000393217.2	+	8	1961	c.1900G>A	c.(1900-1902)Gaa>Aaa	p.E634K		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	634										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		ACAAGAAAAAGAAATTTATTC	0.294000													8	30					0	0	1	0	0
ACVR1C	130399	broad.mit.edu	37	2	158395161	158395161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158395161G>A	ENST00000243349.7	-	8	1640	c.1280C>T	c.(1279-1281)tCg>tTg	p.S427L	ACVR1C_ENST00000335450.7_Missense_Mutation_p.S347L|ACVR1C_ENST00000348328.5_Missense_Mutation_p.S270L|ACVR1C_ENST00000409680.3_Missense_Mutation_p.S377L	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	427	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity	p.S427*(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						TTCCTCTATCGAGGGATCTGA	0.363000													23	99					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179562606	179562606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179562606G>A	ENST00000444136.1	+	3	494	c.244G>A	c.(244-246)Gaa>Aaa	p.E82K	TDRD5_ENST00000367614.1_Missense_Mutation_p.E82K|TDRD5_ENST00000294848.8_Missense_Mutation_p.E82K	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	82	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CATTCCAGATGAATCTACCAA	0.373000													8	33					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870993	13870993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13870993G>A	ENST00000265104.4	-	24	3821	c.3717C>T	c.(3715-3717)ttC>ttT	p.F1239F	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1239	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTTTCTTATTGAATTCTTCAA	0.398000									Kartagener syndrome				29	79					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67508495	67508495	+	Missense_Mutation	SNP	C	C	T	rs76231229	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:67508495C>T	ENST00000382713.5	+	8	1062	c.872C>T	c.(871-873)tCg>tTg	p.S291L		NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	291							insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GGGTTTGGTTCGTCAAAGATG	0.473000													54	128					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657238	72657238	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72657238C>T	ENST00000425256.1	-	0	2673					NR_002164.1																						atctcccaatcccttgggact	0.498000													15	33					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135003268	135003268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:135003268C>T	ENST00000304613.3	+	9	1547	c.1526C>T	c.(1525-1527)tCg>tTg	p.S509L	KNDC1_ENST00000368572.2_Missense_Mutation_p.S509L|KNDC1_ENST00000368571.2_Missense_Mutation_p.S444L			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	509	KIND 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		TCCTATGACTCGTTCTTTCTG	0.642000													14	32					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62462974	62462974	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:62462974G>A	ENST00000430451.2	+	1	434	c.237G>A	c.(235-237)gaG>gaA	p.E79E	SYT16_ENST00000446982.2_Silent_p.E79E	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	79										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GGAGTCAAGAGGATGCAAATT	0.378000													18	169					0	0	1	0	0
PTPRA	5786	broad.mit.edu	37	20	3016271	3016271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3016271C>T	ENST00000216877.6	+	20	2334	c.1934C>T	c.(1933-1935)tCc>tTc	p.S645F	PTPRA_ENST00000318266.5_Missense_Mutation_p.S645F|PTPRA_ENST00000358719.4_Missense_Mutation_p.S510F|PTPRA_ENST00000380393.3_Missense_Mutation_p.S654F|PTPRA_ENST00000399903.2_Missense_Mutation_p.S654F|PTPRA_ENST00000425918.2_Missense_Mutation_p.S665F|PTPRA_ENST00000356147.3_Missense_Mutation_p.S645F	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	654	Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGACTGGTGTCCTATGGAGAT	0.532000													11	28					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10781819	10781819	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10781819G>T	ENST00000361367.2	+	6	1118	c.692G>T	c.(691-693)tGc>tTc	p.C231F		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	231					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AATTCCAAATGCGTGGGAGCA	0.438000													36	87					1.67305e-13	1.68153e-13	1	1	0
RBM19	9904	broad.mit.edu	37	12	114282476	114282476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:114282476G>A	ENST00000545145.2	-	23	2860	c.2782C>T	c.(2782-2784)Cac>Tac	p.H928Y	RBM19_ENST00000261741.5_Missense_Mutation_p.H928Y|RBM19_ENST00000392561.3_Missense_Mutation_p.H928Y	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	928					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CTCCTACCGTGAAAGTGAGCG	0.657000													4	11					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14465696	14465696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14465696C>T	ENST00000344204.4	+	37	5734	c.5710C>T	c.(5710-5712)Ccg>Tcg	p.P1904S	TRIO_ENST00000537187.1_Missense_Mutation_p.P1904S|TRIO_ENST00000515710.1_3'UTR	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	1904					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					CTCCGAAACACCGAGTGCAGC	0.517000													11	97					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92797198	92797198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:92797198G>A	ENST00000377067.3	+	7	1889	c.1517G>A	c.(1516-1518)gGa>gAa	p.G506E		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	506						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GGTTGCGGGGGATCAGGAAGT	0.433000													47	66					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73464826	73464826	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73464826G>A	ENST00000224721.6	+	24	2912	c.2907G>A	c.(2905-2907)cgG>cgA	p.R969R	CDH23_ENST00000299366.7_Silent_p.R1009R	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	964	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACCAGCTGCGGGTGGTGGCCA	0.662000													21	49					0	0	1	0	0
ARHGAP18	93663	broad.mit.edu	37	6	129921871	129921871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:129921871G>A	ENST00000368149.2	-	11	1576	c.1488C>T	c.(1486-1488)tcC>tcT	p.S496S		NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	496	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		GCTGTTCACTGGACTTCAATC	0.363000													27	78					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31286903	31286903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31286903G>A	ENST00000332585.6	+	8	1916	c.1812G>A	c.(1810-1812)ggG>ggA	p.G604G	OSBP2_ENST00000401475.1_Silent_p.G237G|OSBP2_ENST00000535268.1_Silent_p.G148G|OSBP2_ENST00000407373.1_Silent_p.G431G|OSBP2_ENST00000403222.3_Silent_p.G438G|OSBP2_ENST00000446658.2_Silent_p.G603G|OSBP2_ENST00000382310.3_Silent_p.G555G|OSBP2_ENST00000437268.2_Silent_p.G346G	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	604					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						CCATGCTGGGGGAGACCTTCG	0.662000											OREG0026467	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	50					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72520464	72520464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72520464C>T	ENST00000373208.1	+	22	3536	c.3536C>T	c.(3535-3537)tCc>tTc	p.S1179F	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.S1176F	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	1176	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CCTGGAGCATCCTGGAGCATC	0.632000													22	54					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748286	143748286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143748286C>T	ENST00000408906.2	+	1	826	c.792C>T	c.(790-792)tcC>tcT	p.S264S		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CCCCCAAGTCCCGCCACCCTG	0.572000													60	131					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166658	19166658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19166658G>A	ENST00000375371.3	-	6	1976	c.1955C>T	c.(1954-1956)tCt>tTt	p.S652F		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	652					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GATCTGGAAAGAACGCACGGC	0.617000													55	114					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227942792	227942792	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227942792C>T	ENST00000396625.3	-	25	2012	c.1803_splice	c.e25-1	p.G602_splice	COL4A4_ENST00000329662.7_Splice_Site_p.G602_splice	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	602	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTCATGATCCCCCTGGGAATG	0.507000													14	22					0	0	1	0	0
MCOLN2	255231	broad.mit.edu	37	1	85424379	85424379	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85424379G>A	ENST00000370608.3	-	3	311	c.244C>T	c.(244-246)Cgt>Tgt	p.R82C	MCOLN2_ENST00000531325.1_5'UTR|MCOLN2_ENST00000284027.5_Missense_Mutation_p.R54C	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	82						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		AAACCAAAACGAACAAGCTAA	0.333000													14	47					0	0	1	0	0
CCDC170	80129	broad.mit.edu	37	6	151894528	151894528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:151894528G>A	ENST00000367290.5	+	6	1083	c.994G>A	c.(994-996)Gcc>Acc	p.A332T	CCDC170_ENST00000239374.7_Missense_Mutation_p.A332T			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	332																	GAAAATCGCAGCCCTCCTTAG	0.502000													26	33					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77808752	77808752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:77808752G>A	ENST00000269397.4	-	5	866	c.689C>T	c.(688-690)cCc>cTc	p.P230L		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	230	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CATTCCGTTGGGGGGGCCCTT	0.642000											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	118					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17228395	17228395	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:17228395G>A	ENST00000261381.6	-	9	2046	c.1962C>T	c.(1960-1962)tcC>tcT	p.S654S	CTD-2576D5.4_ENST00000567344.1_RNA	NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	654					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGCGGGCAAAGGAGTGGTACA	0.622000													25	72					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68396090	68396090	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68396090G>A	ENST00000297770.4	-	8	966	c.751C>T	c.(751-753)Cga>Tga	p.R251*	CPA6_ENST00000518549.1_Nonsense_Mutation_p.R251*|CPA6_ENST00000297769.4_Nonsense_Mutation_p.R103*	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	251					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			CTCCAAAATCGATCCTAGACA	0.393000													70	138					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16328098	16328098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:16328098G>A	ENST00000244769.4	-	8	1380	c.444C>T	c.(442-444)atC>atT	p.I148I	ATXN1_ENST00000436367.1_Silent_p.I148I	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	148					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CGGTTGGGGGGATCAGCTGTG	0.632000													32	96					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63316460	63316460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:63316460G>A	ENST00000322893.7	-	8	1748	c.1480C>T	c.(1480-1482)Ctc>Ttc	p.L494F	KCNH5_ENST00000420622.2_Missense_Mutation_p.L494F|KCNH5_ENST00000394968.1_Missense_Mutation_p.L436F	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	494					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACCTGATAGAGTTTTAGGAAG	0.393000													42	105					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31896655	31896655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31896655G>A	ENST00000477310.1	+	3	432	c.403G>A	c.(403-405)Ggc>Agc	p.G135S	CFB_ENST00000456570.1_Intron|C2_ENST00000442278.2_Intron|C2_ENST00000452323.2_Intron|C2_ENST00000469372.1_Intron|C2_ENST00000299367.5_Missense_Mutation_p.G135S|CFB_ENST00000556679.1_Intron|C2_ENST00000418949.2_Missense_Mutation_p.G135S			P00751	CFAB_HUMAN	complement factor B	149	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TCGCCCCAACGGCATGTGGGA	0.622000													22	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584010	179584010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179584010G>A	ENST00000589042.1	-	83	24331	c.24107C>T	c.(24106-24108)tCg>tTg	p.S8036L	TTN_ENST00000342992.6_Missense_Mutation_p.S6792L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S7719L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7719							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACGTTTTCCGAAAAGCTGGA	0.507000													28	139					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62751905	62751905	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62751905C>T	ENST00000377871.3	-	1	524	c.258G>A	c.(256-258)tgG>tgA	p.W86*	SLC22A6_ENST00000458333.2_Nonsense_Mutation_p.W86*|SLC22A6_ENST00000421062.2_Nonsense_Mutation_p.W86*|SLC22A6_ENST00000360421.4_Nonsense_Mutation_p.W86*	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	86					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						AGGGCAGTCCCCACTGCGGGG	0.637000													21	123					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10465272	10465272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10465272G>A	ENST00000525621.1	-	19	3112	c.2631C>T	c.(2629-2631)gtC>gtT	p.V877V	TYK2_ENST00000264818.6_Silent_p.V877V|TYK2_ENST00000524462.1_Silent_p.V692V	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	877					intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TCACAGTCAAGACGTCAGCAA	0.582000													29	62					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21136298	21136298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21136298G>A	ENST00000269228.5	-	8	1789	c.1235C>T	c.(1234-1236)gCc>gTc	p.A412V	NPC1_ENST00000540608.1_5'UTR|NPC1_ENST00000412552.2_Missense_Mutation_p.A162V	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	412					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGTGAGAGGGGCCCGGATGAT	0.562000													25	53					0	0	1	0	0
MTMR8	55613	broad.mit.edu	37	X	63445416	63445416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:63445416G>A	ENST00000453546.1	-	10	1329	c.1240C>T	c.(1240-1242)Ctc>Ttc	p.L414F	ASB12_ENST00000362002.2_Missense_Mutation_p.L39F|ASB12_ENST00000396130.2_Missense_Mutation_p.L30F			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						GCTTGATTGAGAGCCTGCTTC	0.517000													4	15					0	0	1	0	0
SIAH3	283514	broad.mit.edu	37	13	46358047	46358047	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46358047T>A	ENST00000400405.2	-	2	387	c.281A>T	c.(280-282)gAg>gTg	p.E94V		NM_198849.2	NP_942146.2	Q8IW03	SIAH3_HUMAN	siah E3 ubiquitin protein ligase family member 3	94	His-rich.				multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			large_intestine(3)|lung(7)|ovary(1)|skin(1)	12						CAGCCCCGCCTCCtggtggtg	0.692000													17	36					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35802840	35802840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35802840C>T	ENST00000361922.4	+	10	1786	c.1636C>T	c.(1636-1638)Ccc>Tcc	p.P546S	MAG_ENST00000392213.3_Missense_Mutation_p.P546S|MAG_ENST00000593348.1_3'UTR|MAG_ENST00000537831.2_Missense_Mutation_p.P521S	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	546					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GACAGAGAGCCCCAGCTTCTC	0.607000													6	18					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69344659	69344659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69344659C>T	ENST00000305363.4	+	9	1124	c.1060C>T	c.(1060-1062)Cct>Tct	p.P354S		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	354	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						CGCCATAACTCCTAGAATGTT	0.393000													50	185					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51742772	51742772	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51742772G>A	ENST00000262262.4	+	7	945		c.e7-1		CD33_ENST00000421133.2_Splice_Site|CD33_ENST00000600557.1_Splice_Site	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule						cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CTCTCCATAAGAAACACCAGA	0.502000													19	41					0	0	1	0	0
TM4SF19	116211	broad.mit.edu	37	3	196053858	196053858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:196053858C>T	ENST00000446879.1	-	3	372	c.247G>A	c.(247-249)Ggc>Agc	p.G83S	TM4SF19_ENST00000454715.1_Intron|TM4SF19_ENST00000273695.3_Missense_Mutation_p.G83S			Q96DZ7	T4S19_HUMAN	transmembrane 4 L six family member 19	83						integral to membrane				endometrium(2)|kidney(2)|large_intestine(3)|lung(5)	12	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;3.94e-24)|all cancers(36;4.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.53e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		CTGAAGCAGCCGTATCTCCAG	0.512000													8	25					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69283116	69283116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69283116G>A	ENST00000338352.2	+	1	776	c.742G>A	c.(742-744)Gag>Aag	p.E248K		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	248	OTU.									autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						CATCGGGGAGGAGTACGTCAA	0.657000													13	16					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81381515	81381515	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:81381515C>T	ENST00000222390.5	-	5	772	c.546G>A	c.(544-546)ggG>ggA	p.G182G	HGF_ENST00000457544.2_Silent_p.G177G|HGF_ENST00000453411.1_Silent_p.G177G|HGF_ENST00000444829.2_Silent_p.G182G|HGF_ENST00000423064.2_Silent_p.G182G	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	182	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CCCCTTCTTCCCCTCGAGGAT	0.433000													8	103					0	0	1	0	0
HIST1H4C	8364	broad.mit.edu	37	6	26104318	26104318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26104318C>T	ENST00000377803.2	+	1	215	c.143C>T	c.(142-144)tCc>tTc	p.S48F		NM_003542.3	NP_003533.1	P62805	H4_HUMAN	histone cluster 1, H4c	48					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7						AAGCGCATTTCCGGTCTTATC	0.537000													21	53					0	0	1	0	0
CNN1	1264	broad.mit.edu	37	19	11658696	11658696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11658696G>A	ENST00000592923.1	+	6	902	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	CNN1_ENST00000252456.2_Missense_Mutation_p.E159K|CNN1_ENST00000544952.1_Missense_Mutation_p.E139K|CNN1_ENST00000535659.2_Missense_Mutation_p.E109K			P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	159	CH.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9						GAAGCTAAGAGAAGGGCGGAA	0.582000													20	27					0	0	1	0	0
RAB20	55647	broad.mit.edu	37	13	111176459	111176459	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111176459C>T	ENST00000267328.3	-	2	471	c.258G>A	c.(256-258)caG>caA	p.Q86Q		NM_017817.1	NP_060287.1	Q9NX57	RAB20_HUMAN	RAB20, member RAS oncogene family	86					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding			endometrium(2)|large_intestine(2)|lung(3)	7	all_cancers(4;1.54e-11)|all_epithelial(4;1.22e-06)|all_lung(23;1e-05)|Lung NSC(43;0.000453)|Colorectal(4;0.00323)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.197)			CCACCAGGCTCTGCCGGTGAT	0.627000													15	67					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179413153	179413153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179413153C>T	ENST00000589042.1	-	339	93424	c.93200G>A	c.(93199-93201)aGt>aAt	p.S31067N	TTN_ENST00000342992.6_Missense_Mutation_p.S28499N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S22002N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S22194N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S22127N|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S29426N|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29426	Ig-like 139.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATTTTTCACTGATAACCTG	0.483000													56	215					0	0	1	0	0
TTC23	64927	broad.mit.edu	37	15	99740154	99740154	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:99740154G>A	ENST00000394132.2	-	9	1546	c.729C>T	c.(727-729)ctC>ctT	p.L243L	TTC23_ENST00000558613.1_Silent_p.L243L|TTC23_ENST00000394129.2_Silent_p.L243L|TTC23_ENST00000262074.4_Silent_p.L243L|TTC23_ENST00000394130.1_Silent_p.L243L|TTC23_ENST00000394136.1_Silent_p.L243L|TTC23_ENST00000558663.1_Silent_p.L243L|TTC23_ENST00000394135.3_Silent_p.L243L			Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	243							binding			endometrium(2)|large_intestine(3)|lung(9)|urinary_tract(2)	16	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			ATACATCGTGGAGTCCCAGGG	0.468000													79	111					0	0	1	0	0
CAMK2A	815	broad.mit.edu	37	5	149652720	149652720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149652720C>T	ENST00000348628.6	-	2	730	c.65G>A	c.(64-66)gGa>gAa	p.G22E	CAMK2A_ENST00000398376.3_Missense_Mutation_p.G22E	NM_015981.3|NM_171825.2	NP_057065.2|NP_741960.1	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II alpha	22	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)	15		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGAGAAGGCTCCCCTAGGAGG	0.567000													14	69					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63277357	63277357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63277357C>T	ENST00000415491.2	+	3	977	c.363C>T	c.(361-363)ttC>ttT	p.F121F	LGALS12_ENST00000394618.3_Silent_p.F182F|LGALS12_ENST00000425950.2_Silent_p.F121F|LGALS12_ENST00000340246.5_Silent_p.F183F|LGALS12_ENST00000255684.5_Silent_p.F182F	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	182	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						CTGTTGGATTCCTGAACATCA	0.557000													5	24					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168678418	168678418	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168678418G>A	ENST00000519560.1	-	2	662	c.243C>T	c.(241-243)ttC>ttT	p.F81F	SLIT3_ENST00000521130.1_5'UTR|SLIT3_ENST00000332966.8_Silent_p.F81F|SLIT3_ENST00000404867.3_Silent_p.F81F	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	81					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGAGCCCAGCGAAGTCCATCT	0.433000													32	95					0	0	1	0	0
ACVR1B	91	broad.mit.edu	37	12	52370317	52370317	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52370317C>T	ENST00000257963.4	+	3	615	c.538C>T	c.(538-540)Cag>Tag	p.Q180*	ACVR1B_ENST00000541224.1_Nonsense_Mutation_p.Q180*|ACVR1B_ENST00000415850.2_Nonsense_Mutation_p.Q180*|ACVR1B_ENST00000426655.2_Nonsense_Mutation_p.Q180*|ACVR1B_ENST00000542485.1_Nonsense_Mutation_p.Q128*	NM_004302.4|NM_020328.3	NP_004293.1|NP_064733.3	P36896	ACV1B_HUMAN	activin A receptor, type IB	180	GS.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			breast(5)|endometrium(4)|kidney(5)|large_intestine(12)|lung(10)|ovary(1)|pancreas(6)|prostate(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	CAAGACGCTCCAGGATCTTGT	0.502000													16	113					0	0	1	0	0
KRT77	374454	broad.mit.edu	37	12	53086630	53086630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53086630C>T	ENST00000341809.3	-	6	1143	c.1115G>A	c.(1114-1116)gGa>gAa	p.G372E	KRT77_ENST00000537195.1_Missense_Mutation_p.G139E|RP11-641A6.3_ENST00000547533.1_RNA	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	372	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CAGGTCGTCTCCATGTCTCCC	0.587000													16	55					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74275217	74275217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74275217C>T	ENST00000409262.3	+	1	1768	c.1768C>T	c.(1768-1770)Ccc>Tcc	p.P590S		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	590							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTTTGGGCTTCCCGGCCCCCC	0.592000													18	41					0	0	1	0	0
HDAC7	51564	broad.mit.edu	37	12	48190922	48190922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48190922G>A	ENST00000080059.7	-	7	580	c.581C>T	c.(580-582)tCt>tTt	p.S194F	HDAC7_ENST00000427332.2_Missense_Mutation_p.S155F|HDAC7_ENST00000380610.4_Missense_Mutation_p.S211F|HDAC7_ENST00000354334.3_Missense_Mutation_p.S194F|HDAC7_ENST00000552960.1_Missense_Mutation_p.S177F	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	155	Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding	p.S155F(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		GTTGGGCTCAGAGACTGCAGG	0.592000													40	87					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74824584	74824584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74824584G>A	ENST00000256362.4	+	2	1339	c.1098G>A	c.(1096-1098)agG>agA	p.R366R		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	366					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TGCCCCCCAGGGAGGTGCTGG	0.652000													20	35					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24578591	24578591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24578591C>T	ENST00000319715.4	+	15	2149	c.1717C>T	c.(1717-1719)Cct>Tct	p.P573S	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Missense_Mutation_p.P573S	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	573					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		ccatacacttcctctccctcc	0.572000													18	192					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42914141	42914141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42914141G>A	ENST00000372565.3	-	3	690	c.421C>T	c.(421-423)Ctt>Ttt	p.L141F	ZMYND12_ENST00000433602.2_Intron	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	141						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CACTCACCAAGGCTGGCCTCG	0.532000													6	21					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24861028	24861028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:24861028C>T	ENST00000424834.2	+	9	3080	c.2607C>T	c.(2605-2607)gtC>gtT	p.V869V	SPATA13_ENST00000343003.6_Silent_p.V188V|SPATA13_ENST00000409126.1_Intron|SPATA13_ENST00000399949.2_Silent_p.V166V|SPATA13_ENST00000382108.3_Silent_p.V869V|SPATA13_ENST00000382095.4_Silent_p.V244V			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	244					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GGACCAACGTCATCCGGGAGA	0.602000													29	68					0	0	1	0	0
CCP110	9738	broad.mit.edu	37	16	19547602	19547602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19547602C>T	ENST00000396212.2	+	5	1047	c.611C>T	c.(610-612)cCc>cTc	p.P204L	CCP110_ENST00000396208.2_Missense_Mutation_p.P204L|CCP110_ENST00000381396.5_Missense_Mutation_p.P204L	NM_014711.4	NP_055526.3	O43303	CP110_HUMAN	centriolar coiled coil protein 110kDa	204	CEP97 binding.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|stomach(3)|urinary_tract(1)	21						TCTGATGGTCCCTTCTCAGTA	0.393000													57	107					0	0	1	0	0
MIR299	407023	broad.mit.edu	37	14	101490176	101490176	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101490176G>A	ENST00000385016.2	+	0	63					NR_029841.1																						ATGTATGTGGGATGGTAAACC	0.532000													22	64					0	0	1	0	0
GLUD1	2746	broad.mit.edu	37	10	88818945	88818945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88818945G>A	ENST00000277865.4	-	10	1460	c.1364C>T	c.(1363-1365)aCc>aTc	p.T455I	GLUD1_ENST00000537649.1_Missense_Mutation_p.T288I|GLUD1_ENST00000544149.1_Missense_Mutation_p.T322I	NM_005271.3	NP_005262.1	P00367	DHE3_HUMAN	glutamate dehydrogenase 1	455					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(11)|prostate(1)	22					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATATTTGAAGGTCAAACGGCC	0.398000													66	183					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44676255	44676255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44676255C>T	ENST00000588883.1	+	4	338	c.30C>T	c.(28-30)ttC>ttT	p.F10F	ZNF226_ENST00000590089.1_Silent_p.F10F|ZNF226_ENST00000300823.6_Silent_p.F10F|ZNF226_ENST00000588742.1_Silent_p.F10F|ZNF226_ENST00000589160.1_Silent_p.F10F|ZNF226_ENST00000337433.5_Silent_p.F10F|ZNF226_ENST00000413984.2_Silent_p.F10F|ZNF226_ENST00000454662.2_Silent_p.F10F|ZNF226_ENST00000588795.1_Silent_p.F10F			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				CAGTGACCTTCAAGGACGTGG	0.507000													42	141					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7833869	7833869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7833869G>A	ENST00000327325.5	+	7	1313	c.1195G>A	c.(1195-1197)Gaa>Aaa	p.E399K	CLEC4M_ENST00000248228.4_Missense_Mutation_p.E377K|CLEC4M_ENST00000595496.1_Missense_Mutation_p.E263K|CLEC4M_ENST00000596707.1_Missense_Mutation_p.E332K|CLEC4M_ENST00000334806.5_Missense_Mutation_p.E348K|CLEC4M_ENST00000596363.1_3'UTR|CLEC4M_ENST00000597522.1_3'UTR|CLEC4M_ENST00000357361.2_3'UTR|CLEC4M_ENST00000394122.2_Missense_Mutation_p.E387K|CLEC4M_ENST00000359059.5_Missense_Mutation_p.E332K	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	399					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						CTTCAGAGACGAATAGTTGTT	0.498000													17	64					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76797772	76797772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76797772C>T	ENST00000286719.7	-	11	1344	c.988G>A	c.(988-990)Gag>Aag	p.E330K		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	330	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTTCTCTTCTCCTCCATCTGC	0.517000													18	64					0	0	1	0	0
ARHGEF38	54848	broad.mit.edu	37	4	106534592	106534592	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:106534592C>T	ENST00000420470.2	+	3	580	c.436C>T	c.(436-438)Cag>Tag	p.Q146*	ARHGEF38_ENST00000265154.2_Nonsense_Mutation_p.Q146*	NM_001242729.1	NP_001229658.1	Q9NXL2	ARH38_HUMAN	Rho guanine nucleotide exchange factor (GEF) 38	146	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(3)	11						GTCCGTGCATCAGATATCAGC	0.438000													12	157					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43652765	43652765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:43652765G>A	ENST00000378069.4	-	8	976	c.829C>T	c.(829-831)Cct>Tct	p.P277S	MAOB_ENST00000536181.1_Missense_Mutation_p.P261S|MAOB_ENST00000538942.1_Missense_Mutation_p.P261S	NM_000898.4	NP_000889.3	P27338	AOFB_HUMAN	monoamine oxidase B	277					xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(2)|skin(5)	21					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	ATTGGCAGAGGGGGATTGAAG	0.413000													48	34					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331570	85331570	+	Silent	SNP	G	G	A	rs142600008		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85331570G>A	ENST00000440886.1	-	1	272	c.234C>T	c.(232-234)ttC>ttT	p.F78F	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Silent_p.F78F			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	78					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						CAATTCCAGCGAAGAAATCGG	0.433000													23	180					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21227996	21227996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21227996G>A	ENST00000233242.1	-	26	11871	c.11744C>T	c.(11743-11745)tCc>tTc	p.S3915F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3915					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCTGCATGTGGAATCCAGGAC	0.418000													56	122					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55269448	55269448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55269448C>T	ENST00000275493.2	+	26	3312	c.3135C>T	c.(3133-3135)tcC>tcT	p.S1045S	EGFR_ENST00000454757.2_Silent_p.S992S|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_Silent_p.S1000S	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	1045	Ser-rich.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GCAACAATTCCACCGTGGCTT	0.433000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			45	117					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24125674	24125674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24125674C>T	ENST00000598975.1	-	1	471	c.472G>A	c.(472-474)Ggg>Agg	p.G158R	MMP11_ENST00000215743.3_Silent_p.P470P																							AAGGCTTCCCCCGTCTCGTGG	0.607000													31	76					0	0	1	0	0
C1orf141	400757	broad.mit.edu	37	1	67561082	67561082	+	Missense_Mutation	SNP	C	C	T	rs145496311		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:67561082C>T	ENST00000371007.2	-	7	548	c.439G>A	c.(439-441)Gat>Aat	p.D147N	C1orf141_ENST00000371006.1_Missense_Mutation_p.D147N|C1orf141_ENST00000544837.1_Missense_Mutation_p.D147N	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	147										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						ATATTAAAATCGTTCATCTGT	0.363000													5	25					0	0	1	0	0
NR2F1	7025	broad.mit.edu	37	5	92923983	92923983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:92923983C>T	ENST00000327111.3	+	2	2511	c.824C>T	c.(823-825)cCg>cTg	p.P275L		NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	275					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CACGTGGCGCCGTTGCTGGCC	0.662000													23	59					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86370031	86370031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:86370031C>T	ENST00000400286.2	-	2	1211	c.613G>A	c.(613-615)Gaa>Aaa	p.E205K		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	205						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CCAATGTGTTCGAGAAAACCA	0.403000													24	120					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40698283	40698283	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40698283C>T	ENST00000253055.3	+	1	633	c.345C>T	c.(343-345)gcC>gcT	p.A115A	MAP3K10_ENST00000593906.1_3'UTR	NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	115	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						TCTATCGGGCCCTGTGGCGTG	0.682000													4	21					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333310	70333310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70333310G>A	ENST00000338508.4	-	32	3090	c.3091C>T	c.(3091-3093)Cct>Tct	p.P1031S	SHANK2_ENST00000449833.2_Missense_Mutation_p.P435S|SHANK2_ENST00000423696.2_Missense_Mutation_p.P651S|SHANK2_ENST00000409161.1_Missense_Mutation_p.P434S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	651					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GTCGGGATAGGGATGGAGCAC	0.662000													51	125					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104897581	104897581	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:104897581T>G	ENST00000533400.1	-	8	1139	c.1104A>C	c.(1102-1104)gaA>gaC	p.E368D	CASP1_ENST00000525825.1_Missense_Mutation_p.E347D|CASP1_ENST00000526568.1_Missense_Mutation_p.E275D|CASP1_ENST00000531166.1_Missense_Mutation_p.E52D|CASP1_ENST00000527979.1_Missense_Mutation_p.E331D|CASP1_ENST00000393136.4_Missense_Mutation_p.E347D|CASP1_ENST00000415981.2_Missense_Mutation_p.E52D|CASP1_ENST00000528974.1_3'UTR|CASP1_ENST00000593315.1_Missense_Mutation_p.E347D|CASP1_ENST00000446369.1_Missense_Mutation_p.E227D|CASP1_ENST00000353247.5_Missense_Mutation_p.E52D|CASP1_ENST00000594519.1_Missense_Mutation_p.E227D|CASP1_ENST00000436863.3_Missense_Mutation_p.E368D|CASP1_ENST00000534497.1_Missense_Mutation_p.E227D|CASP1_ENST00000598974.1_Missense_Mutation_p.E368D	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	368					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TGCGGAAAATTTCCTCCACAT	0.408000													26	72					0	0	1	0	0
PXK	54899	broad.mit.edu	37	3	58368345	58368345	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58368345G>A	ENST00000463280.1	+	2	298	c.207G>A	c.(205-207)gtG>gtA	p.V69V	PXK_ENST00000356151.2_Silent_p.V102V|PXK_ENST00000383716.3_Silent_p.V69V|PXK_ENST00000484288.1_Silent_p.V102V|PXK_ENST00000479241.1_Silent_p.V85V|PXK_ENST00000302779.5_Silent_p.V85V|PXK_ENST00000536660.1_Intron|PXK_ENST00000383715.4_Silent_p.V85V			Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	102	PX.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		ATCTCAACGTGATCACAACAA	0.388000													25	56					0	0	1	0	0
CHAF1B	8208	broad.mit.edu	37	21	37788600	37788600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37788600C>T	ENST00000314103.4	+	14	1767	c.1616C>T	c.(1615-1617)cCc>cTc	p.P539L		NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)	539					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						CAGGGCAGTCCCCCAGAGCTA	0.517000													10	30					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111397710	111397710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111397710G>A	ENST00000265162.5	+	1	482	c.140G>A	c.(139-141)gGg>gAg	p.G47E		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	47					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GACTCCAGCGGGGACGGCGGG	0.632000													46	131					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26872494	26872494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26872494C>T	ENST00000531382.1	+	1	152	c.103C>T	c.(103-105)Cct>Tct	p.P35S	RPS6KA1_ENST00000526792.1_Intron|RPS6KA1_ENST00000374166.4_Intron|RPS6KA1_ENST00000374168.2_Intron|RPS6KA1_ENST00000374162.2_Intron|RPS6KA1_ENST00000530003.1_Intron	NM_001006665.1	NP_001006666.1	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	26					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TCTGCCTGTCCCTGGCCCTGG	0.687000													3	25					0	0	1	0	0
SEC14L4	284904	broad.mit.edu	37	22	30891358	30891358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30891358G>A	ENST00000392772.2	-	5	421	c.144C>T	c.(142-144)atC>atT	p.I48I	SEC14L4_ENST00000540456.1_Silent_p.I87I|SEC14L4_ENST00000381982.3_Silent_p.I102I|SEC14L4_ENST00000255858.7_Silent_p.I102I			Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	102						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	GGGACCCAATGATGTTGAAGT	0.547000													25	67					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73677031	73677031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73677031C>T	ENST00000264448.6	+	8	3485	c.3374C>T	c.(3373-3375)gCt>gTt	p.A1125V	ALMS1_ENST00000409009.1_Missense_Mutation_p.A1083V|ALMS1_ENST00000377715.1_Missense_Mutation_p.A1125V	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1125	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ATTTCAGTAGCTCCTGGACTA	0.473000													50	227					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137593095	137593095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137593095C>T	ENST00000371817.3	+	4	984	c.570C>T	c.(568-570)ttC>ttT	p.F190F	COL5A1_ENST00000464187.1_3'UTR	NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	190	Laminin G-like.|TSP N-terminal.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCACCAAATTCCTCGACCGCA	0.512000													7	28					0	0	1	0	0
PA2G4	5036	broad.mit.edu	37	12	56504236	56504236	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56504236T>C	ENST00000303305.6	+	8	1102	c.683T>C	c.(682-684)gTt>gCt	p.V228A	RP11-603J24.17_ENST00000548595.1_RNA|PA2G4_ENST00000552766.1_Missense_Mutation_p.V228A	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	228					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			GCTGTGGATGTTCTCGTCAGC	0.408000													38	66					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28966722	28966722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28966722C>T	ENST00000359747.4	+	3	185	c.156C>T	c.(154-156)atC>atT	p.I52I	DSG4_ENST00000308128.4_Silent_p.I52I|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	52	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGGAGTGGATCAAGTTTGCCG	0.438000													9	110					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103149037	103149037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103149037G>A	ENST00000295269.4	+	12	2744	c.2287G>A	c.(2287-2289)Gag>Aag	p.E763K		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	763					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GTCTGGAGGGGAGAGTGAGGG	0.552000													11	31					0	0	1	0	0
WISP2	8839	broad.mit.edu	37	20	43355771	43355771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43355771C>T	ENST00000372865.4	+	3	837	c.329C>T	c.(328-330)tCc>tTc	p.S110F	WISP2_ENST00000471629.1_3'UTR|RP11-445H22.4_ENST00000445420.1_RNA|RP11-445H22.4_ENST00000427303.1_RNA|WISP2_ENST00000372868.2_Silent_p.V192V|WISP2_ENST00000190983.4_Silent_p.V192V|RP11-445H22.4_ENST00000427598.1_RNA			O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	99	VWFC.				cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CCCCTGGTGTCCCCTGCCCAG	0.632000													57	107					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125805234	125805234	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:125805234G>A	ENST00000346248.5	-	2	1137	c.495C>T	c.(493-495)ttC>ttT	p.F165F	CHST15_ENST00000435907.1_Silent_p.F165F|CHST15_ENST00000421115.1_Silent_p.F165F	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	165					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						GTCTGGTCGTGAACTCAATCC	0.383000													109	284					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29121164	29121164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29121164C>T	ENST00000261590.8	+	13	2097	c.1888C>T	c.(1888-1890)Ctt>Ttt	p.L630F		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	630					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGTGGTACCACTTTTACTGCT	0.423000													25	74					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45303824	45303824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:45303824C>T	ENST00000303230.4	-	6	1552	c.1495G>A	c.(1495-1497)Gga>Aga	p.G499R		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	499						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.G499L(1)|p.G499R(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ATATAATCTCCAGGTTGAAAC	0.408000													33	135					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933065	43933065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43933065C>T	ENST00000537548.1	-	4	690	c.446G>A	c.(445-447)cGg>cAg	p.R149Q	MATN4_ENST00000372754.1_Missense_Mutation_p.R149Q|MATN4_ENST00000342716.4_Missense_Mutation_p.R149Q|MATN4_ENST00000372753.1_Intron|MATN4_ENST00000372751.4_Intron|MATN4_ENST00000353917.5_Missense_Mutation_p.R149Q|MATN4_ENST00000372756.1_Missense_Mutation_p.R149Q|MATN4_ENST00000360607.5_Missense_Mutation_p.R149Q			O95460	MATN4_HUMAN	matrilin 4	149	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				GTCCTGGGGCCGCCCGTCTGT	0.721000													3	12					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103410325	103410325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103410325G>A	ENST00000361246.2	-	30	4599	c.4311C>T	c.(4309-4311)taC>taT	p.Y1437Y		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1437	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		AGCAAAGCAGGTACTCCTCGC	0.582000													27	50					0	0	1	0	0
CBLN4	140689	broad.mit.edu	37	20	54579090	54579090	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:54579090C>T	ENST00000064571.2	-	1	1438	c.138G>A	c.(136-138)tcG>tcA	p.S46S		NM_080617.4	NP_542184.1	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	46						cell junction|extracellular region|synapse				endometrium(2)|large_intestine(1)|lung(10)|ovary(3)|pancreas(1)	17			Colorectal(105;0.202)			TGGCCGGGTTCGAGTCGCACA	0.687000													10	46					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207643161	207643161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207643161G>A	ENST00000367057.3	+	6	1128	c.939G>A	c.(937-939)gtG>gtA	p.V313V	CR2_ENST00000367059.3_Silent_p.V313V|CR2_ENST00000458541.2_Silent_p.V313V|CR2_ENST00000367058.3_Silent_p.V313V|CR2_ENST00000485707.1_3'UTR	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	313	Sushi 5.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						AGGAAGGAGTGAACTTCATCC	0.483000													26	58					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810695	7810695	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7810695G>A	ENST00000315599.7	-	4	479	c.457C>T	c.(457-459)Ctg>Ttg	p.L153L	CD209_ENST00000593660.1_Silent_p.L129L|CD209_ENST00000602261.1_Silent_p.L153L|CD209_ENST00000601951.1_Silent_p.L129L|CD209_ENST00000394161.5_Intron|CD209_ENST00000593821.1_Silent_p.L109L|CD209_ENST00000204801.8_Silent_p.L109L|CD209_ENST00000601256.1_Silent_p.L129L|CD209_ENST00000315591.8_Silent_p.L129L|CD209_ENST00000394173.4_Intron|CD209_ENST00000301357.8_Intron|CD209_ENST00000354397.6_Silent_p.L153L	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	153	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCAGCCTTCAGCCAGGTCAGC	0.562000													76	178					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160109728	160109728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160109728C>T	ENST00000361216.3	+	22	3077	c.2988C>T	c.(2986-2988)ttC>ttT	p.F996F	ATP1A2_ENST00000392233.3_Silent_p.F985F	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	996					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TCCTCATCTTCATCTATGATG	0.577000													33	124					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32037544	32037544	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32037544G>A	ENST00000375244.3	-	15	5574	c.5373C>T	c.(5371-5373)tcC>tcT	p.S1791S	TNXB_ENST00000375247.2_Silent_p.S1791S			P22105	TENX_HUMAN	tenascin XB	1873	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AGAGGCCCACGGAGTTCTGGG	0.617000													6	24					0	0	1	0	0
PHKB	5257	broad.mit.edu	37	16	47628107	47628107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:47628107C>T	ENST00000455779.1	+	13	1350	c.1165C>T	c.(1165-1167)Ctt>Ttt	p.L389F	PHKB_ENST00000323584.5_Missense_Mutation_p.L396F|PHKB_ENST00000299167.8_Missense_Mutation_p.L396F|PHKB_ENST00000566044.1_Missense_Mutation_p.L389F			Q93100	KPBB_HUMAN	phosphorylase kinase, beta	396					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GACTCCAGTACTTCATCATAC	0.313000													7	66					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10551334	10551334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10551334G>A	ENST00000396560.2	+	7	1527	c.1300G>A	c.(1300-1302)Gga>Aga	p.G434R	ATF7IP2_ENST00000356427.2_Missense_Mutation_p.G434R|ATF7IP2_ENST00000396559.1_Missense_Mutation_p.G434R|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000324570.5_Missense_Mutation_p.G434R	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						TTCCGAAAAAGGAAGTAAAAA	0.294000													43	110					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402853	124402853	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124402853A>G	ENST00000368909.3	+	53	7287	c.7181A>G	c.(7180-7182)gAc>gGc	p.D2394G	DMBT1_ENST00000330163.4_Missense_Mutation_p.D1766G|DMBT1_ENST00000368955.3_Missense_Mutation_p.D2384G|DMBT1_ENST00000359586.6_Missense_Mutation_p.D1114G|DMBT1_ENST00000368956.2_Missense_Mutation_p.D1766G|DMBT1_ENST00000344338.3_Missense_Mutation_p.D2384G|DMBT1_ENST00000338354.3_Missense_Mutation_p.D2394G	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2394					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GAAAAGGTGGACGTCGTCCTG	0.627000													21	42					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16360108	16360108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16360108G>A	ENST00000375692.1	+	21	2144	c.2016G>A	c.(2014-2016)atG>atA	p.M672I	CLCNKA_ENST00000420078.1_Missense_Mutation_p.M672I|CLCNKA_ENST00000439316.2_Missense_Mutation_p.M630I|CLCNKA_ENST00000464764.1_3'UTR|CLCNKA_ENST00000331433.4_Missense_Mutation_p.M673I			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	673	CBS 2.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	TGTTCTAGATGAAGAAAGCAA	0.552000													15	55					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113237474	113237474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113237474C>T	ENST00000369644.1	+	11	2437	c.1408C>T	c.(1408-1410)Cca>Tca	p.P470S	MOV10_ENST00000413052.2_Missense_Mutation_p.P526S|RP11-426L16.3_ENST00000421943.1_RNA|MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000357443.2_Missense_Mutation_p.P526S|MOV10_ENST00000369645.1_Missense_Mutation_p.P526S			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	526					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CTTTGGGCCTCCAGGCACCGG	0.597000													5	65					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14022150	14022150	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:14022150C>T	ENST00000382080.1	-	5	1201	c.486G>A	c.(484-486)agG>agA	p.R162R	RP11-3G21.1_ENST00000527110.1_RNA|SGCZ_ENST00000421524.2_Silent_p.R115R	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	149					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		AAAACAGCACCCTGCCATCTT	0.413000													27	57					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179475048	179475048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179475048C>T	ENST00000589042.1	-	271	51429	c.51205G>A	c.(51205-51207)Gaa>Aaa	p.E17069K	TTN_ENST00000342992.6_Missense_Mutation_p.E14501K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E8004K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E8196K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E8129K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E15428K|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15428	Ig-like 102.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGGAGGTTCCCAAGTTAAC	0.398000													53	114					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55223540	55223540	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55223540G>A	ENST00000275493.2	+	8	1084	c.907G>A	c.(907-909)Gat>Aat	p.D303N	EGFR_ENST00000344576.2_Missense_Mutation_p.D303N|EGFR_ENST00000420316.2_Missense_Mutation_p.D303N|EGFR_ENST00000454757.2_Missense_Mutation_p.D250N|EGFR_ENST00000442591.1_Missense_Mutation_p.D303N|EGFR_ENST00000342916.3_Missense_Mutation_p.D303N|EGFR_ENST00000455089.1_Missense_Mutation_p.D258N	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	303					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.D303H(2)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGTGGTGACAGATCACGGCTC	0.597000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			16	81					0	0	1	0	0
FEZF1	389549	broad.mit.edu	37	7	121944331	121944331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121944331C>T	ENST00000442488.2	-	1	228	c.161G>A	c.(160-162)gGa>gAa	p.G54E	FEZF1_ENST00000331178.4_Missense_Mutation_p.G54E|FEZF1-AS1_ENST00000428449.1_RNA|FEZF1_ENST00000427185.2_Missense_Mutation_p.G54E	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	54					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						GGGTAAGGCTCCCTGCAGGAA	0.597000													45	117					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47282381	47282381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47282381C>T	ENST00000335044.2	-	17	2191	c.1834G>A	c.(1834-1836)Gag>Aag	p.E612K	KIF9_ENST00000487440.1_5'UTR|KIF9_ENST00000352910.4_Missense_Mutation_p.E454K|KIF9_ENST00000265529.3_Missense_Mutation_p.E612K|KIF9_ENST00000452770.2_Missense_Mutation_p.E612K|KIF9-AS1_ENST00000429315.3_RNA|KIF9_ENST00000444589.2_Missense_Mutation_p.E547K	NM_001134878.1|NM_182902.3	NP_001128350.1|NP_878905.2	Q9HAQ2	KIF9_HUMAN	kinesin family member 9	612					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TGTGTGGTCTCGCTGGCCCTT	0.458000													41	90					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31914822	31914822	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31914822G>A	ENST00000456570.1	+	15	1898	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K	CFB_ENST00000425368.2_Missense_Mutation_p.E113K|CFB_ENST00000477310.1_Missense_Mutation_p.E464K|CFB_ENST00000556679.1_Missense_Mutation_p.E615K			P00751	CFAB_HUMAN	complement factor B	113	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CGAGAACGGGGAATACTGGCC	0.532000													29	61					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926255	1926255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1926255C>T	ENST00000399161.2	-	10	2033	c.1286G>A	c.(1285-1287)gGg>gAg	p.G429E	MYT1L_ENST00000428368.2_Missense_Mutation_p.G429E	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	429					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGTCAGGTTCCCCTTGGTCAT	0.552000													35	91					0	0	1	0	0
SPAG1	6674	broad.mit.edu	37	8	101178079	101178079	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101178079T>A	ENST00000388798.2	+	3	369	c.178T>A	c.(178-180)Ttt>Att	p.F60I	SPAG1_ENST00000520643.1_Missense_Mutation_p.F60I|SPAG1_ENST00000520508.1_Missense_Mutation_p.F60I|SPAG1_ENST00000251809.3_Missense_Mutation_p.F60I	NM_003114.4	NP_003105.2	Q07617	SPAG1_HUMAN	sperm associated antigen 1	60					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		ACTTACAGAATTTTGTGAAAA	0.398000													20	69					0	0	1	0	0
RPS6KB2	6199	broad.mit.edu	37	11	67201482	67201482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67201482C>T	ENST00000312629.5	+	11	968	c.923C>T	c.(922-924)cCc>cTc	p.P308L	AP003419.16_ENST00000535922.1_RNA	NM_003952.2	NP_003943.2	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 2	308	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|salivary_gland(1)|stomach(2)	25			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			AAACGGAATCCCAGCCAGCGG	0.642000													7	53					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616242	179616242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179616242C>T	ENST00000360870.5	-	46	11107	c.10885G>A	c.(10885-10887)Gat>Aat	p.D3629N	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9478	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTATCCTATCTTCTCCCCTT	0.368000													91	173					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31599462	31599462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31599462C>T	ENST00000376033.2	+	16	3246	c.3012C>T	c.(3010-3012)tcC>tcT	p.S1004S	PRRC2A_ENST00000376007.4_Silent_p.S1004S	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1004	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						GAAATCTTTCCCCTGCCCCAA	0.592000													10	18					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123754798	123754798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123754798G>A	ENST00000375026.2	-	3	663	c.447C>T	c.(445-447)ttC>ttT	p.F149F		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	149						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						CAGACAAGAAGAAAACATTTA	0.433000													16	91					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109690130	109690130	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:109690130C>T	ENST00000277225.5	+	3	4226	c.3937C>T	c.(3937-3939)Cac>Tac	p.H1313Y	ZNF462_ENST00000441147.2_Missense_Mutation_p.H158Y|ZNF462_ENST00000457913.1_Missense_Mutation_p.H1313Y			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1313					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						AGCTGGCTACCACTGCGAGTG	0.517000													14	141					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113168633	113168633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113168633C>T	ENST00000401783.2	-	38	9583	c.9247G>A	c.(9247-9249)Gaa>Aaa	p.E3083K	SVEP1_ENST00000374469.1_Missense_Mutation_p.E3060K|SVEP1_ENST00000297826.5_Missense_Mutation_p.E1009K	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3083	Sushi 28.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ATCACATTTTCCTTCCAAGAG	0.473000													39	132					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189872637	189872637	+	Silent	SNP	C	C	T	rs148918486		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189872637C>T	ENST00000304636.3	+	46	3560	c.3390C>T	c.(3388-3390)atC>atT	p.I1130I	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1130	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AGGGTGCAATCGGCAGTCCAG	0.468000													32	85					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634323	32634323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32634323C>T	ENST00000242310.4	-	1	1344	c.1255G>A	c.(1255-1257)Gaa>Aaa	p.E419K	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	419					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGGAAGTTTTCGTCAGCCAGA	0.443000													65	246					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580483	140580483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580483G>A	ENST00000354757.3	+	1	1136	c.1136G>A	c.(1135-1137)gGa>gAa	p.G379E	PCDHB11_ENST00000536699.1_Missense_Mutation_p.G14E	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		379	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGGACAACGGAAGAATTGTT	0.433000													35	114					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138578	126138578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:126138578C>T	ENST00000299308.3	+	9	2567	c.2559C>T	c.(2557-2559)ccC>ccT	p.P853P	TMEM132B_ENST00000535886.1_Silent_p.P365P	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	853						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCCAGTCTCCCATGGAAGGGA	0.522000													12	54					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8609249	8609249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8609249C>T	ENST00000338257.8	-	14	1723	c.1456G>A	c.(1456-1458)Gct>Act	p.A486T		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	486	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GTCCCCACAGCCGCCTGCAGC	0.672000													13	28					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207108834	207108834	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207108834C>T	ENST00000356495.4	-	5	1558	c.1375G>A	c.(1375-1377)Gaa>Aaa	p.E459K		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	459						extracellular region|integral to plasma membrane	protein binding	p.E459K(1)		central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTCCTACCTTCGATAATCTTG	0.567000											OREG0014186	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	78					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115394878	115394878	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:115394878G>A	ENST00000393780.3	+	3	625	c.157G>A	c.(157-159)Gac>Aac	p.D53N	GAP43_ENST00000305124.6_Missense_Mutation_p.D17N	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	17	IQ.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		AAATGATGACGACCAAAAGAT	0.373000													37	68					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236208779	236208779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236208779C>T	ENST00000264187.6	-	3	812	c.730G>A	c.(730-732)Gaa>Aaa	p.E244K	NID1_ENST00000366595.3_Missense_Mutation_p.E244K	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	244	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TCAACTGATTCCCTGTCATTA	0.363000													26	60					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2110321	2110321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:2110321C>T	ENST00000382203.1	+	24	3569	c.3360C>T	c.(3358-3360)ttC>ttT	p.F1120F	SMARCA2_ENST00000382194.1_Silent_p.F1120F|SMARCA2_ENST00000349721.2_Silent_p.F1120F|SMARCA2_ENST00000357248.2_Silent_p.F1120F			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1120	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CCCAGTATTTCATTTTCTTGC	0.453000													26	57					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92533756	92533756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92533756G>A	ENST00000298047.6	+	9	7594	c.7577G>A	c.(7576-7578)gGg>gAg	p.G2526E	FAT3_ENST00000409404.2_Missense_Mutation_p.G2526E|FAT3_ENST00000525166.1_Missense_Mutation_p.G2376E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2526	Cadherin 23.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGTGATCCAGGGACTTATGGG	0.493000										TCGA Ovarian(4;0.039)			4	19					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142458426	142458426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142458426G>A	ENST00000486171.1	+	2	78	c.61G>A	c.(61-63)Gat>Aat	p.D21N	PRSS1_ENST00000311737.7_Missense_Mutation_p.D21N			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	21					digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CTTTGATGATGATGACAAGAT	0.532000													53	257					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561151	9561151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9561151C>T	ENST00000378429.3	-	5	1177	c.631G>A	c.(631-633)Gaa>Aaa	p.E211K	PAK7_ENST00000378423.1_Missense_Mutation_p.E211K|PAK7_ENST00000353224.5_Missense_Mutation_p.E211K	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	211	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TCACTGTATTCACTTGGTTTG	0.483000													39	75					0	0	1	0	0
GGTLC2	91227	broad.mit.edu	37	22	22989341	22989341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22989341C>T	ENST00000448514.1	+	2	294	c.294C>T	c.(292-294)ttC>ttT	p.F98F	GGTLC2_ENST00000480559.1_Silent_p.F98F			Q14390	GGTL2_HUMAN	gamma-glutamyltransferase light chain 2	98					glutathione biosynthetic process		gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		CTGCCAATTTCATCCAGCCAG	0.612000													72	168					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17668547	17668547	+	Silent	SNP	C	C	T	rs138788718	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17668547C>T	ENST00000375448.4	+	7	788	c.762C>T	c.(760-762)ctC>ctT	p.L254L	AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	254					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	TGGAGGCCCTCGCTTTCCCGG	0.617000													21	54					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196965187	196965187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196965187G>A	ENST00000367414.5	+	6	954	c.898G>A	c.(898-900)Gag>Aag	p.E300K	CFHR5_ENST00000256785.4_Missense_Mutation_p.E276K	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	276	Sushi 5.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						ACCTGAACTCGAGTACGGTTA	0.348000													37	114					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2129298	2129298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2129298C>T	ENST00000219476.3	+	28	3783	c.3153C>T	c.(3151-3153)ctC>ctT	p.L1051L	TSC2_ENST00000401874.2_Silent_p.L1007L|TSC2_ENST00000350773.4_Silent_p.L1051L|TSC2_ENST00000439673.2_Silent_p.L971L|TSC2_ENST00000568454.1_Silent_p.L1018L|TSC2_ENST00000382538.6_Silent_p.L959L|TSC2_ENST00000568366.1_3'UTR|TSC2_ENST00000353929.4_Silent_p.L1008L	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1051					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				GCGAGTTCCTCCTAGCGGGTG	0.637000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				28	45					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50147111	50147111	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50147111G>A	ENST00000376025.2	-	0	1073							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TGCAGTGCTGGGTCCGGTGGC	0.433000													21	13					0	0	1	0	0
FAM46D	169966	broad.mit.edu	37	X	79698625	79698625	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:79698625A>T	ENST00000538312.1	+	5	921	c.587A>T	c.(586-588)aAa>aTa	p.K196I	FAM46D_ENST00000308293.5_Missense_Mutation_p.K196I	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	196										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						AAGCTAACCAAAGAATCCTAT	0.403000													38	18					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72862917	72862917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72862917G>A	ENST00000455107.2	-	4	543	c.127C>T	c.(127-129)Ccc>Tcc	p.P43S	FDXR_ENST00000582944.1_Missense_Mutation_p.P87S|FDXR_ENST00000544854.1_Missense_Mutation_p.P35S|FDXR_ENST00000442102.2_Missense_Mutation_p.P130S|FDXR_ENST00000413947.2_Missense_Mutation_p.P118S|FDXR_ENST00000293195.5_Missense_Mutation_p.P87S|FDXR_ENST00000581530.1_Missense_Mutation_p.P87S|FDXR_ENST00000420580.2_Missense_Mutation_p.P88S|FDXR_ENST00000583917.1_Missense_Mutation_p.P88S|FDXR_ENST00000581969.1_5'UTR			P22570	ADRO_HUMAN	ferredoxin reductase	87					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					TTCACCTCGGGGTGATCAGGC	0.632000													14	33					0	0	1	0	0
UCP1	7350	broad.mit.edu	37	4	141484541	141484541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141484541G>A	ENST00000262999.3	-	3	532	c.457C>T	c.(457-459)Cgc>Tgc	p.R153C		NM_021833.4	NP_068605.1	P25874	UCP1_HUMAN	uncoupling protein 1 (mitochondrial, proton carrier)	153					brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|stomach(1)	16	all_hematologic(180;0.162)					CCCGTGTAGCGAGGTTTGATT	0.463000													47	86					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141902	133141902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133141902C>T	ENST00000388996.4	-	15	2646	c.2226G>A	c.(2224-2226)gtG>gtA	p.V742V	KCNQ3_ENST00000519445.1_Silent_p.V730V|KCNQ3_ENST00000521134.1_Silent_p.V622V	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	742					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGGGCCTCTCCACATACGTTG	0.592000													17	27					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178442297	178442297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:178442297C>T	ENST00000448150.3	+	18	4551	c.3733C>T	c.(3733-3735)Cgc>Tgc	p.R1245C	RASAL2_ENST00000367649.3_Missense_Mutation_p.R1256C|RASAL2_ENST00000462775.1_Missense_Mutation_p.R1115C	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	1115					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						CATGCAGGTCCGCAATGGCAT	0.542000													26	78					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6174838	6174838	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6174838G>A	ENST00000264870.3	-	12	1987	c.1722C>T	c.(1720-1722)ttC>ttT	p.F574F		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	574					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GCGTCACGTCGAACGTCTCCT	0.522000													57	147					0	0	1	0	0
OR6C1	390321	broad.mit.edu	37	12	55714563	55714563	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55714563C>T	ENST00000379668.2	+	1	218	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_001005182.1	NP_001005182.1	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C, member 1	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|liver(2)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	25						TGTATTTCTTCCTCAGAAATT	0.418000													33	80					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43821218	43821218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43821218C>T	ENST00000389420.3	-	27	3999	c.4000G>A	c.(4000-4002)Gaa>Aaa	p.E1334K	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.E452K|ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E1334K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1334	TSP type-1 9.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TGTCCATTTTCATCCTGGCAG	0.488000													18	40					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699504	52699504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52699504G>A	ENST00000293525.5	+	6	1010	c.958G>A	c.(958-960)Gag>Aag	p.E320K	KRT86_ENST00000544024.1_Missense_Mutation_p.E320K|KRT86_ENST00000423955.2_Missense_Mutation_p.E320K	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	320	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCGCACCAAGGAGGAGATCAA	0.597000													8	87					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46835200	46835200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46835200G>A	ENST00000262738.3	-	3	4291	c.4292C>T	c.(4291-4293)cCt>cTt	p.P1431L		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1431	EGF-like 3; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CTCGCCAGGAGGACACACGCA	0.647000													7	68					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75113409	75113409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75113409G>A	ENST00000310715.3	-	3	275	c.155C>T	c.(154-156)cCa>cTa	p.P52L	TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000340329.3_Missense_Mutation_p.P52L|TTC18_ENST00000401621.2_Missense_Mutation_p.P52L|TTC18_ENST00000394865.1_Missense_Mutation_p.P52L|TTC18_ENST00000355577.3_5'UTR	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	52							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					ACTTCCTTCTGGAGAAACAGT	0.403000													19	84					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241808421	241808421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241808421G>A	ENST00000307503.3	+	1	526	c.139G>A	c.(139-141)Ggg>Agg	p.G47R		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	47					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GCAGATGATCGGGTCCATGAG	0.642000													36	73					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168101389	168101389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168101389C>T	ENST00000409195.1	+	9	3576	c.3487C>T	c.(3487-3489)Cgt>Tgt	p.R1163C	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R1163C|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.R941C	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	988					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGGGGATGTTCGTACAGCATG	0.403000													17	81					0	0	1	0	0
SET	6418	broad.mit.edu	37	9	131455961	131455961	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131455961G>A	ENST00000322030.8	+	6	894	c.537G>A	c.(535-537)agG>agA	p.R179R	SET_ENST00000372692.4_Silent_p.R192R|SET_ENST00000477806.1_3'UTR|SET_ENST00000372688.4_Silent_p.R168R|SET_ENST00000409104.3_Silent_p.R170R	NM_003011.3	NP_003002.2	Q01105	SET_HUMAN	SET nuclear oncogene	192					DNA replication|mRNA metabolic process|negative regulation of histone acetylation|negative regulation of neuron apoptosis|negative regulation of transcription, DNA-dependent|nucleocytoplasmic transport|nucleosome assembly|nucleosome disassembly	cytosol|endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm|protein complex	histone binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity			endometrium(2)|kidney(1)|lung(2)	5		Myeloproliferative disorder(178;0.204)		GBM - Glioblastoma multiforme(294;3.1e-09)		AAGCCAGCAGGAAGAGGCAGC	0.438000			T	NUP214	AML								7	70					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19070876	19070876	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19070876G>A	ENST00000569532.1	+	15	2296	c.2166G>A	c.(2164-2166)agG>agA	p.R722R	TMC7_ENST00000421369.3_Intron|TMC7_ENST00000304381.5_Intron			Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	111						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						ACACTGCAAGGAAAGTGCTGT	0.557000													9	28					0	0	1	0	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95373839	95373839	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:95373839G>A	ENST00000494840.1	-	0	2022					NR_077228.1																						AAGCTCTTTAGACGTCAGCAC	0.448000													3	11					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72846421	72846421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72846421G>A	ENST00000293190.5	-	6	1561	c.1415C>T	c.(1414-1416)tCc>tTc	p.S472F	GRIN2C_ENST00000347612.4_Missense_Mutation_p.S472F	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	472					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CAGGTCGTAGGAGAATTTGAC	0.607000													49	118					0	0	1	0	0
SMPD4P1	645280	broad.mit.edu	37	22	20977088	20977088	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20977088C>T	ENST00000443839.1	-	0	1446																											ACAAGGACACCATCCAGGCTG	0.582000													7	9					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82816544	82816544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82816544G>A	ENST00000265077.3	+	7	2984	c.2419G>A	c.(2419-2421)Gaa>Aaa	p.E807K	VCAN_ENST00000342785.4_Missense_Mutation_p.E807K|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000512590.2_Missense_Mutation_p.E759K	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	807	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding	p.E807K(1)		NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GTCATGGGATGAAGATAATAC	0.413000													15	97					0	0	1	0	0
IL23A	51561	broad.mit.edu	37	12	56733246	56733246	+	Missense_Mutation	SNP	G	G	A	rs150940553		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56733246G>A	ENST00000228534.4	+	2	365	c.199G>A	c.(199-201)Gat>Aat	p.D67N		NM_016584.2	NP_057668.1	Q9NPF7	IL23A_HUMAN	interleukin 23, alpha subunit p19	67					defense response to Gram-negative bacterium|inflammatory response|innate immune response|negative regulation of interleukin-10 production|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to virus|tissue remodeling	interleukin-23 complex	cytokine activity			kidney(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	5						GACTACAAATGATGTTCCCCA	0.493000													15	58					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033245	82033245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82033245C>T	ENST00000328945.5	-	3	780	c.653G>A	c.(652-654)aGc>aAc	p.S218N		NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	218					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CTCAACCAGGCTCCTGGGGTC	0.557000													51	141					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151108512	151108512	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151108512G>A	ENST00000341697.3	-	13	2925	c.1234C>T	c.(1234-1236)Cag>Tag	p.Q412*				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	412	Sema.					integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGTAGAGGCTGATGGGTGACA	0.557000													31	54					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178557010	178557010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178557010C>T	ENST00000251582.7	-	16	2481	c.2380G>A	c.(2380-2382)Gag>Aag	p.E794K		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	794	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TACTCCCACTCCACGCCCATG	0.582000													20	62					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150715528	150715528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150715528G>A	ENST00000605938.1	-	7	1800	c.1725C>T	c.(1723-1725)ttC>ttT	p.F575F	ATG9B_ENST00000377974.2_Silent_p.F575F|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_Silent_p.F61F	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	575					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTCCGGAATGAAAGACCTGA	0.677000											OREG0018444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	48					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43569108	43569108	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43569108G>C	ENST00000452443.2	-	12	1929	c.1925C>G	c.(1924-1926)aCg>aGg	p.T642R		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	642					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CAGCACCATCGTGCAGCTGCT	0.582000													21	42					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120150415	120150415	+	Silent	SNP	G	G	A	rs147828404		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120150415G>A	ENST00000392521.2	-	36	4720	c.4665C>T	c.(4663-4665)ctC>ctT	p.L1555L	CIT_ENST00000261833.7_Silent_p.L1513L|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1513	PH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTGTATTTGCGAGTTCGGAAG	0.607000													13	73					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56822682	56822682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56822682G>A	ENST00000229201.4	-	11	1440	c.1286C>T	c.(1285-1287)gCc>gTc	p.A429V	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Missense_Mutation_p.A430V	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	430			A -> D (in a breast cancer sample; somatic mutation).		cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TGCCCAGGAGGCAGCTTCCTT	0.522000													29	44					0	0	1	0	0
ZBTB33	10009	broad.mit.edu	37	X	119388433	119388433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:119388433C>T	ENST00000326624.2	+	2	1391	c.1163C>T	c.(1162-1164)tCc>tTc	p.S388F	ZBTB33_ENST00000557385.1_Missense_Mutation_p.S388F	NM_006777.3	NP_006768.1	Q86T24	KAISO_HUMAN	zinc finger and BTB domain containing 33	388					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	26						CTTTCCAATTCCTTAAAAATT	0.363000													47	42					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513660	99513660	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:99513660G>A	ENST00000261037.3	+	5	1295	c.915G>A	c.(913-915)ggG>ggA	p.G305G	COL8A1_ENST00000273342.4_Silent_p.G305G	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	305	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGGTACCGGGGGTTCAAGGAC	0.642000													16	30					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67399174	67399174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67399174G>A	ENST00000335385.3	-	8	1147	c.1060C>T	c.(1060-1062)Cgg>Tgg	p.R354W		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	354					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						CTATCAGCCCGGATGTTGGGG	0.652000													3	17					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20492235	20492235	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20492235C>T	ENST00000573854.1	+	12	1615	c.1501C>T	c.(1501-1503)Cga>Tga	p.R501*	ACSM2A_ENST00000575690.1_Nonsense_Mutation_p.R501*|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Nonsense_Mutation_p.R501*|ACSM2A_ENST00000536134.1_Nonsense_Mutation_p.R273*|ACSM2A_ENST00000417235.2_Nonsense_Mutation_p.R422*|ACSM2A_ENST00000396104.2_Nonsense_Mutation_p.R501*	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	501					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AGACCCCGTCCGAGGAGAGGT	0.562000													13	39					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214772	161214772	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161214772C>T	ENST00000327928.4	+	1	177	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	59						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AAACCCTCTTCACAGAAATGG	0.468000													30	72					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8196452	8196452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8196452G>A	ENST00000600128.1	-	15	2390	c.1976C>T	c.(1975-1977)cCt>cTt	p.P659L	FBN3_ENST00000601739.1_Missense_Mutation_p.P659L|FBN3_ENST00000270509.2_Missense_Mutation_p.P659L			Q75N90	FBN3_HUMAN	fibrillin 3	659	TB 3.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTCTTTGGCAGGACAAAGCTG	0.642000													12	102					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113346348	113346348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113346348C>T	ENST00000452357.2	+	2	378	c.188C>T	c.(187-189)tCc>tTc	p.S63F	OAS1_ENST00000445409.2_Missense_Mutation_p.S63F|OAS1_ENST00000553185.1_Missense_Mutation_p.S63F|OAS1_ENST00000202917.5_Missense_Mutation_p.S63F|RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000551241.1_Missense_Mutation_p.S63F	NM_002534.2	NP_002525.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	63					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						CAGGGTGGCTCCTCAGGCAAG	0.478000													20	42					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25610343	25610343	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25610343C>T	ENST00000329474.6	+	36	4281	c.3913C>T	c.(3913-3915)Cct>Tct	p.P1305S		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1305					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						GAAAAAAGTTCCTTCAGACAA	0.473000													46	116					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43214429	43214429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43214429G>A	ENST00000259750.4	+	2	114	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	11						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCTTAAGGACGAAACCAACAT	0.667000													12	40					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140219477	140219477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:140219477G>A	ENST00000275884.6	-	18	3370	c.2953C>T	c.(2953-2955)Ccc>Tcc	p.P985S	DENND2A_ENST00000537639.1_Missense_Mutation_p.P985S|DENND2A_ENST00000496613.1_Missense_Mutation_p.P985S			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	985										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					TCTCCACTGGGGAGTGTTTCC	0.527000													10	144					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37670762	37670762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37670762G>A	ENST00000264741.5	+	16	2030	c.1774G>A	c.(1774-1776)Gaa>Aaa	p.E592K	ITGA9_ENST00000422441.1_Missense_Mutation_p.E592K	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	592					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GGAGGAGAGGGAACTGCCGCC	0.517000													11	31					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37187885	37187885	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37187885G>A	ENST00000425901.2	+	0	1727					NR_033753.2																						TTTGGATCTGGAACTTACCTT	0.488000													29	44					0	0	1	0	0
RNA5-8SP2	100873571	broad.mit.edu	37	16	33965525	33965525	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:33965525C>T	ENST00000363564.1	+	0	100																											ATCGACACTTCGAACGCAATT	0.572000													9	33					0	0	1	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266304	3266304	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3266304G>A	ENST00000576468.1	+	0	418																											ATCCACAAAGGGAAGATGGAA	0.522000													15	43					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42754799	42754799	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42754799C>T	ENST00000310232.6	-	14	1811	c.1728G>A	c.(1726-1728)gaG>gaA	p.E576E		NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	576										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						TGCTGTTGCTCTCCTCCACCC	0.612000													12	117					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466838	56466838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56466838G>A	ENST00000291971.3	+	3	1485	c.1414G>A	c.(1414-1416)Gaa>Aaa	p.E472K	NLRP8_ENST00000590542.1_Missense_Mutation_p.E472K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	472	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GTTAGGTAAAGAAGATCTTGA	0.498000													42	110					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62144067	62144067	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62144067G>A	ENST00000433197.2	-	8	901	c.806C>T	c.(805-807)cCg>cTg	p.P269L		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	269					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						CTTGGGGAACGGGTACTTCCA	0.592000													16	29					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139416468	139416468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139416468G>A	ENST00000406875.3	-	2	460	c.366C>T	c.(364-366)ctC>ctT	p.L122L	HIPK2_ENST00000428878.2_Silent_p.L122L|HIPK2_ENST00000342645.6_Silent_p.L122L	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	122	Transcriptional corepression (By similarity).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					AGGTATCAAGGAGGCTCACAG	0.552000													12	26					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100159990	100159990	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:100159990G>A	ENST00000370575.4	-	5	388	c.340C>T	c.(340-342)Cga>Tga	p.R114*	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	114							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						TAGGGGTTTCGAAGATGAAGC	0.522000													20	44					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480281	73480281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73480281G>A	ENST00000523207.1	+	2	900	c.312G>A	c.(310-312)cgG>cgA	p.R104R		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	104					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			ATTTCTACCGGACCGGGAAAC	0.463000													29	64					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20149272	20149272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:20149272C>T	ENST00000395530.2	+	6	2350	c.2142C>T	c.(2140-2142)gtC>gtT	p.V714V	AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000261503.5_Silent_p.V795V|SPECC1_ENST00000395527.4_Silent_p.V795V|SPECC1_ENST00000536879.1_Silent_p.V135V	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	795						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		CCTCTGAGGTCGATGCTGCTG	0.502000													22	38					0	0	1	0	0
DNAJC1	64215	broad.mit.edu	37	10	22048148	22048148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:22048148G>A	ENST00000376980.3	-	11	1837	c.1547C>T	c.(1546-1548)tCc>tTc	p.S516F		NM_022365.3	NP_071760.2	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	516	SANT 2.				negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(13)|skin(2)|upper_aerodigestive_tract(2)	21		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				GCGGTCAGAGGATCCCCTTGG	0.542000													49	185					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102995	22102995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22102995C>T	ENST00000542433.1	-	1	101	c.4G>A	c.(4-6)Gga>Aga	p.G2R		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TTGGTCTTTCCCATGTCTTTT	0.438000													25	92					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234041375	234041375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:234041375G>A	ENST00000366618.3	+	2	299	c.154G>A	c.(154-156)Gag>Aag	p.E52K		NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	0					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GGCGATTAAGGAGGATCTGAA	0.632000													24	74					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69684658	69684658	+	Missense_Mutation	SNP	C	C	T	rs144426334		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:69684658C>T	ENST00000370598.1	+	9	2350	c.1529C>T	c.(1528-1530)cCt>cTt	p.P510L		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	510					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ATTGCAGCACCTTATGAAATA	0.413000													7	65					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535774	27535774	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27535774G>A	ENST00000574842.1	+	0	255																											CGGGGGACAGGTCAGTGCCCA	0.498000													51	178					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82447513	82447513	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:82447513C>T	ENST00000370728.1	+	21	3768	c.3123C>T	c.(3121-3123)ttC>ttT	p.F1041F	LPHN2_ENST00000359929.3_Silent_p.F1028F|LPHN2_ENST00000394879.1_Silent_p.F1043F|LPHN2_ENST00000370730.1_Silent_p.F1041F|LPHN2_ENST00000271029.4_Silent_p.F1056F|LPHN2_ENST00000370715.1_Silent_p.F1028F|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000335786.5_Silent_p.F1041F|LPHN2_ENST00000370725.1_Silent_p.F1056F|LPHN2_ENST00000370723.1_Silent_p.F1043F|LPHN2_ENST00000370721.1_Silent_p.F966F|LPHN2_ENST00000370713.1_Silent_p.F1028F|LPHN2_ENST00000319517.6_Silent_p.F1028F|LPHN2_ENST00000370717.2_Silent_p.F1056F|LPHN2_ENST00000370727.1_Silent_p.F1056F			O95490	LPHN2_HUMAN	latrophilin 2	1041					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTGGCGCTTTCGCTCTTCTGT	0.383000													94	318					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808137	48808137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48808137C>T	ENST00000309835.3	+	1	375	c.365C>T	c.(364-366)tCc>tTc	p.S122F	STON1_ENST00000404752.1_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.S122F|STON1_ENST00000406226.1_Missense_Mutation_p.S122F|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.S122F					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGAGAATCTTCCTTACTGCCT	0.473000													32	53					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139274303	139274303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139274303G>A	ENST00000298532.2	-	20	2881	c.2513C>T	c.(2512-2514)gCc>gTc	p.A838V		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	838					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGTGCTCTGGGCACTTGAGGA	0.602000													5	14					0	0	1	0	0
CWC27	10283	broad.mit.edu	37	5	64273001	64273001	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:64273001C>T	ENST00000381070.3	+	13	1409	c.1192C>T	c.(1192-1194)Caa>Taa	p.Q398*	CWC27_ENST00000545000.1_3'UTR	NM_005869.2	NP_005860.2	Q6UX04	CWC27_HUMAN	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	398					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(5)|prostate(1)	21						TAAACTCACTCAAGCAATTGC	0.333000													15	50					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473345	19473345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:19473345C>T	ENST00000507958.1	-	15	3353	c.2363G>A	c.(2362-2364)aGa>aAa	p.R788K	CDH18_ENST00000382275.1_Missense_Mutation_p.R788K|CDH18_ENST00000274170.4_Missense_Mutation_p.R788K|CDH18_ENST00000510297.1_5'UTR			Q13634	CAD18_HUMAN	cadherin 18, type 2	788					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTAAGTTGTTCTTTCAGATTC	0.428000													44	121					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22063225	22063225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:22063225G>A	ENST00000261200.4	-	8	1185	c.1186C>T	c.(1186-1188)Ctt>Ttt	p.L396F	ABCC9_ENST00000261201.4_Missense_Mutation_p.L396F|ABCC9_ENST00000345162.2_Missense_Mutation_p.L396F	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	396	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAGAGCCTAAGGATTTTATTA	0.328000													40	73					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56471297	56471297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56471297G>A	ENST00000370754.5	-	39	8029	c.8030C>T	c.(8029-8031)cCt>cTt	p.P2677L	DST_ENST00000361203.3_Missense_Mutation_p.P2499L|DST_ENST00000312431.6_Missense_Mutation_p.P2499L|DST_ENST00000446842.2_Missense_Mutation_p.P2173L|DST_ENST00000370769.4_Missense_Mutation_p.P2499L|DST_ENST00000370788.2_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000244364.6_Intron			Q03001	DYST_HUMAN	dystonin	2499					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGAGCCAACAGGATTTAAATG	0.378000													20	52					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49823439	49823439	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49823439G>A	ENST00000561648.1	-	2	88	c.35C>T	c.(34-36)tCa>tTa	p.S12L	ZNF423_ENST00000563137.2_5'UTR|ZNF423_ENST00000562520.1_5'UTR|ZNF423_ENST00000262383.2_Missense_Mutation_p.S12L	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	12					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CGAGAAGTCTGAGGCCTCCCC	0.582000													23	35					0	0	1	0	0
LILRA6	79168	broad.mit.edu	37	19	54746089	54746089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54746089C>T	ENST00000440558.2	-	3	216	c.168G>A	c.(166-168)caG>caA	p.Q56Q	LILRA6_ENST00000245621.5_Silent_p.Q56Q|LILRA6_ENST00000419410.2_Silent_p.Q56Q|LILRA6_ENST00000391735.3_Silent_p.Q56Q|LILRB3_ENST00000407860.2_Silent_p.Q56Q|LILRA6_ENST00000270464.5_Silent_p.Q56Q|LILRA6_ENST00000396365.2_Silent_p.Q56Q					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTTGGTACTCCTGGGCCTCCA	0.592000													50	290					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760771	20760771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20760771C>T	ENST00000400451.2	+	5	1962	c.1448C>T	c.(1447-1449)tCc>tTc	p.S483F	ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Missense_Mutation_p.S483F|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000405993.1_Missense_Mutation_p.S451F	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	483					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCTTCAGCTCCCACGCCTAC	0.637000													28	90					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44684879	44684879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44684879G>A	ENST00000454036.1	+	22	3023	c.2947G>A	c.(2947-2949)Gct>Act	p.A983T	SLC12A5_ENST00000243964.3_Missense_Mutation_p.A960T	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	983					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGAAGAGACGGCTGGTGACAG	0.577000													26	54					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25419959	25419959	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25419959G>A	ENST00000549301.1	+	0	694				SNHG14_ENST00000441592.2_RNA																							ggcttcagcaggtccctccgt	0.478000													26	59					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44418361	44418361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44418361G>A	ENST00000269973.5	-	10	2317	c.1227C>T	c.(1225-1227)ggC>ggT	p.G409G	RP11-15A1.2_ENST00000586247.1_RNA|ZNF45_ENST00000589703.1_Silent_p.G409G	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	409					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G409G(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						CTCCAGTATGGCCTCTTTGAT	0.478000													33	101					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99438647	99438647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99438647C>T	ENST00000397899.2	-	7	2420	c.2089G>A	c.(2089-2091)Gat>Aat	p.D697N		NM_207362.2	NP_997245.2			KIAA1211-like																		GAGGCGCCATCCCTGTATTTG	0.637000													4	21					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123594271	123594271	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123594271G>A	ENST00000340011.5	+	3	1004	c.647G>A	c.(646-648)tGg>tAg	p.W216*	SPAM1_ENST00000460182.1_Nonsense_Mutation_p.W216*|SPAM1_ENST00000439500.1_Nonsense_Mutation_p.W216*|SPAM1_ENST00000223028.7_Nonsense_Mutation_p.W216*|SPAM1_ENST00000402183.2_Nonsense_Mutation_p.W216*	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	216					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	AATCACTTGTGGGGTTATTAT	0.373000													34	104					0	0	1	0	0
OR6C76	390326	broad.mit.edu	37	12	55820243	55820243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55820243C>T	ENST00000328314.3	+	1	206	c.206C>T	c.(205-207)tCa>tTa	p.S69L		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TTGGAAATTTCATTTACTTCT	0.393000													37	159					0	0	1	0	0
CRYGC	1420	broad.mit.edu	37	2	208993031	208993031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:208993031C>T	ENST00000282141.3	-	3	458	c.421G>A	c.(421-423)Ggg>Agg	p.G141R		NM_020989.3	NP_066269.1	P07315	CRGC_HUMAN	crystallin, gamma C	141	Beta/gamma crystallin 'Greek key' 4.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens			NS(1)|endometrium(1)|large_intestine(2)|lung(5)	9				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		TATTGCCGCCCCCGGTAGTTG	0.632000													37	88					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28883029	28883029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28883029C>T	ENST00000282397.4	-	28	3922	c.3671G>A	c.(3670-3672)aGa>aAa	p.R1224K	FLT1_ENST00000540678.1_Missense_Mutation_p.R442K|FLT1_ENST00000543394.1_Missense_Mutation_p.R247K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1224					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GGTTTTGATTCTTTCCAGGCT	0.408000													35	64					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71025230	71025230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71025230C>T	ENST00000393567.2	-	25	4005	c.3855G>A	c.(3853-3855)gtG>gtA	p.V1285V		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1285										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CATCTGAGATCACACTGGAAG	0.463000													28	87					0	0	1	0	0
RMI1	80010	broad.mit.edu	37	9	86617114	86617114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:86617114C>T	ENST00000325875.3	+	3	1545	c.1213C>T	c.(1213-1215)Cat>Tat	p.H405Y		NM_024945.2	NP_079221.2	Q9H9A7	RMI1_HUMAN	RecQ mediated genome instability 1	405					DNA replication	nucleus				biliary_tract(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						TTTTTCAGTTCATTGTAATGT	0.313000													45	67					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7681496	7681496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7681496G>A	ENST00000446248.2	+	16	3382	c.3281G>A	c.(3280-3282)aGg>aAg	p.R1094K	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.R1067K	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	1067					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						GGGGTGAAGAGGCCCACGTCT	0.612000													17	49					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17322773	17322773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17322773C>T	ENST00000594824.1	+	40	6275	c.6128C>T	c.(6127-6129)cCt>cTt	p.P2043L	MYO9B_ENST00000595618.1_3'UTR|MYO9B_ENST00000397274.2_3'UTR			Q13459	MYO9B_HUMAN	myosin IXB	2043	Tail.			TVAAPP -> PWPPLH (in Ref. 3; AAC26597).	actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						GTGGCCGCCCCTCCACGACGA	0.692000													7	8					0	0	1	0	0
OTX1	5013	broad.mit.edu	37	2	63282749	63282749	+	Silent	SNP	C	C	T	rs75832508		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:63282749C>T	ENST00000282549.2	+	5	639	c.363C>T	c.(361-363)tcC>tcT	p.S121S	OTX1_ENST00000366671.3_Silent_p.S121S	NM_014562.3	NP_055377.1	P32242	OTX1_HUMAN	orthodenticle homeobox 1	121						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					GCTCGGGCTCCGAAAGCAGTG	0.672000													9	79					0	0	1	0	0
GRAMD2	196996	broad.mit.edu	37	15	72458995	72458995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72458995C>T	ENST00000309731.7	-	7	534	c.521G>A	c.(520-522)aGg>aAg	p.R174K	GRAMD2_ENST00000564184.1_5'UTR	NM_001012642.2	NP_001012660.1	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	174						integral to membrane				cervix(2)|endometrium(1)|large_intestine(4)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	13						GCAGACTCTCCTCAGCAGGTC	0.552000													13	99					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95602890	95602890	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95602890C>A	ENST00000343958.4	-	2	2393	c.2170G>T	c.(2170-2172)Gac>Tac	p.D724Y	FGD6_ENST00000549499.1_Missense_Mutation_p.D724Y|FGD6_ENST00000546711.1_Missense_Mutation_p.D724Y	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	724					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						AGCATTTGGTCATCCAAAGAC	0.463000													19	107					4.63292e-17	4.65946e-17	1	1	0
NTRK2	4915	broad.mit.edu	37	9	87482336	87482336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:87482336G>A	ENST00000304053.6	+	14	2106	c.1623G>A	c.(1621-1623)aaG>aaA	p.K541K	NTRK2_ENST00000376213.1_Silent_p.K525K|NTRK2_ENST00000277120.3_Silent_p.K541K|NTRK2_ENST00000323115.4_Silent_p.K525K|NTRK2_ENST00000376214.1_Silent_p.K541K|NTRK2_ENST00000376208.1_Silent_p.K525K	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	525	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						GTCAGCTCAAGCCAGACACAT	0.463000										TSP Lung(25;0.17)			41	157					0	0	1	0	0
KRTAP5-2	440021	broad.mit.edu	37	11	1619373	1619373	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1619373C>T	ENST00000412090.1	-	1	151	c.108G>A	c.(106-108)ggG>ggA	p.G36G	KRTAP5-AS1_ENST00000424148.1_RNA	NM_001004325.1	NP_001004325.1	Q701N4	KRA52_HUMAN	keratin associated protein 5-2	36						keratin filament				large_intestine(1)|lung(2)|skin(1)	4		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCACAGCCCCCACGGCCGG	0.687000													33	71					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3907853	3907853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3907853G>A	ENST00000450849.2	+	5	947	c.480G>A	c.(478-480)ggG>ggA	p.G160G	ATCAY_ENST00000398448.3_Silent_p.G166G|ATCAY_ENST00000600960.1_Silent_p.G160G|ATCAY_ENST00000301260.6_Silent_p.G160G	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	160					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		TGATCATCGGGGAGCAAGAGC	0.657000													23	41					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31876828	31876828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31876828C>T	ENST00000396184.3	-	12	1373	c.1169G>A	c.(1168-1170)tGg>tAg	p.W390*	PDE1C_ENST00000396182.2_Nonsense_Mutation_p.W390*|PDE1C_ENST00000396191.1_Nonsense_Mutation_p.W390*|PDE1C_ENST00000321453.7_Nonsense_Mutation_p.W390*|PDE1C_ENST00000396193.1_Nonsense_Mutation_p.W450*	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	390	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			TGACATTGTCCAGCGATGATG	0.428000													17	83					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225688361	225688361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:225688361G>A	ENST00000409592.3	-	28	3135	c.3022C>T	c.(3022-3024)Ccc>Tcc	p.P1008S	DOCK10_ENST00000258390.7_Missense_Mutation_p.P1014S			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1014							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGAGGCCGGGGAAGCTAAGGA	0.368000													26	76					0	0	1	0	0
CDC34	997	broad.mit.edu	37	19	532078	532078	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:532078C>T	ENST00000215574.4	+	1	365	c.147C>T	c.(145-147)ccC>ccT	p.P49P		NM_004359.1	NP_004350.1	P49427	UB2R1_HUMAN	cell division cycle 34	49					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(1)	2		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGGCCCCCCAACACCTACT	0.682000													3	12					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71778763	71778763	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71778763G>A	ENST00000258104.3	+	19	1942	c.1665G>A	c.(1663-1665)cgG>cgA	p.R555R	DYSF_ENST00000394120.2_Silent_p.R556R|DYSF_ENST00000409744.1_Silent_p.R542R|DYSF_ENST00000410020.3_Silent_p.R573R|DYSF_ENST00000413539.2_Silent_p.R586R|DYSF_ENST00000429174.2_Silent_p.R555R|DYSF_ENST00000409366.1_Silent_p.R556R|DYSF_ENST00000409582.3_Silent_p.R572R|DYSF_ENST00000409762.1_Silent_p.R572R|DYSF_ENST00000409651.1_Silent_p.R587R|DYSF_ENST00000410041.1_Silent_p.R573R	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	555			R -> W (in isolated hyperCKemia, LGMD2B and MMD1).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATCGTGGCCGGCTTCTGCTCT	0.637000													6	15					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4242186	4242186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4242186C>T	ENST00000399609.3	-	6	1402	c.1390G>A	c.(1390-1392)Gaa>Aaa	p.E464K	SRL_ENST00000537996.1_Missense_Mutation_p.E422K	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	923	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity	p.E464K(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						TTTGGTGTTTCGCTACACCCT	0.557000													64	114					0	0	1	0	0
PTPN9	5780	broad.mit.edu	37	15	75761170	75761170	+	Silent	SNP	G	G	A	rs137863856	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75761170G>A	ENST00000306726.2	-	13	2234	c.1722C>T	c.(1720-1722)ttC>ttT	p.F574F		NM_002833.2	NP_002824.1	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type 9	574	Tyrosine-protein phosphatase.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCTTCTCTGCGAACTCCAGGA	0.542000													35	148					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197411416	197411416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197411416G>A	ENST00000367400.3	+	11	4134	c.3999G>A	c.(3997-3999)gaG>gaA	p.E1333E	CRB1_ENST00000367397.1_3'UTR|RP11-75C23.1_ENST00000422250.1_RNA|CRB1_ENST00000535699.1_Silent_p.E1309E|CRB1_ENST00000538660.1_Silent_p.E797E|CRB1_ENST00000544212.1_Silent_p.E814E|CRB1_ENST00000367399.2_Silent_p.E1221E	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1333	EGF-like 19; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGCGCTGCGAGGTGGACGTAA	0.488000													63	221					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19349166	19349166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19349166C>T	ENST00000252575.5	+	11	3398	c.3355C>T	c.(3355-3357)Cgc>Tgc	p.R1119C	NCAN_ENST00000538881.1_Missense_Mutation_p.R570C	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1119	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding	p.R1133S(1)|p.R1119S(1)		breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CTGCCGCCGCCGCTCCGGCCA	0.652000													27	86					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54617553	54617553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:54617553C>T	ENST00000302287.3	+	4	730	c.324C>T	c.(322-324)atC>atT	p.I108I	VSTM2A_ENST00000402613.3_Silent_p.I108I|VSTM2A_ENST00000498834.1_3'UTR|VSTM2A_ENST00000402026.2_Silent_p.I107I|VSTM2A_ENST00000404951.1_Silent_p.I108I|VSTM2A_ENST00000407838.3_Silent_p.I108I			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	108	Ig-like V-type.					extracellular region		p.I107I(2)|p.I108I(1)		endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			GCAATGACATCTCCCACAAGC	0.408000													10	24					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129906709	129906709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129906709G>A	ENST00000368654.3	-	13	3770	c.3395C>T	c.(3394-3396)cCa>cTa	p.P1132L	MKI67_ENST00000368653.3_Missense_Mutation_p.P772L	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1132	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTCTGGTGGTGGAGATTTGCA	0.463000													158	395					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28136760	28136760	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28136760G>A	ENST00000316334.3	-	5	1143	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	338							zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		GAGCCACTTGGAAAATCTCTT	0.483000													31	93					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48589800	48589800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48589800C>T	ENST00000340553.3	+	5	918	c.657C>T	c.(655-657)caC>caT	p.H219H		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	219					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TATCACCTCACTATTTAAGCT	0.363000													12	79					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656881	40656881	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:40656881G>A	ENST00000406785.1	-	2	729	c.540C>T	c.(538-540)ttC>ttT	p.F180F	SLC8A1_ENST00000408028.2_Silent_p.F180F|SLC8A1_ENST00000542756.1_Silent_p.F180F|SLC8A1_ENST00000542024.1_Silent_p.F180F|SLC8A1_ENST00000403092.1_Silent_p.F180F|SLC8A1_ENST00000405901.3_Silent_p.F180F|SLC8A1_ENST00000405269.1_Silent_p.F180F|SLC8A1_ENST00000332839.4_Silent_p.F180F|SLC8A1_ENST00000402441.1_Silent_p.F180F|SLC8A1_ENST00000406391.2_Silent_p.F180F			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	180					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CAATAATGATGAACATATTGA	0.463000													16	50					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63276393	63276393	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63276393G>A	ENST00000415491.2	+	2	799	c.185G>A	c.(184-186)tGg>tAg	p.W62*	LGALS12_ENST00000394618.3_Nonsense_Mutation_p.W123*|LGALS12_ENST00000425950.2_Nonsense_Mutation_p.W62*|LGALS12_ENST00000340246.5_Nonsense_Mutation_p.W124*|LGALS12_ENST00000255684.5_Nonsense_Mutation_p.W123*	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	123	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						GAGGCCCGGTGGCCCCACCTG	0.592000													18	73					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58533821	58533821	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58533821C>A	ENST00000348616.4	+	1	340	c.40C>A	c.(40-42)Ctt>Att	p.L14I	CDH26_ENST00000244047.5_Missense_Mutation_p.L14I	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	14					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			gctgctgctgcttctagtgct	0.597000													7	29					2.7689e-08	2.77824e-08	1	1	0
CD27	939	broad.mit.edu	37	12	6554699	6554699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6554699G>A	ENST00000266557.3	+	2	475	c.246G>A	c.(244-246)gaG>gaA	p.E82E	CD27-AS1_ENST00000399492.2_RNA|CD27-AS1_ENST00000545339.1_RNA|CD27_ENST00000541233.1_3'UTR	NM_001242.4	NP_001233.1	P26842	CD27_HUMAN	CD27 molecule	82					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						CCCACTGTGAGAGCTGTCGGC	0.597000													6	41					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207640181	207640181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207640181C>T	ENST00000367057.3	+	2	558	c.369C>T	c.(367-369)tcC>tcT	p.S123S	CR2_ENST00000367059.3_Silent_p.S123S|CR2_ENST00000458541.2_Silent_p.S123S|CR2_ENST00000367058.3_Silent_p.S123S	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	123	Sushi 2.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						CCAACTTCTCCATGAACGGAA	0.458000													36	77					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227919409	227919409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227919409C>T	ENST00000396625.3	-	31	2968	c.2761G>A	c.(2761-2763)Gga>Aga	p.G921R	COL4A4_ENST00000329662.7_Missense_Mutation_p.G921R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	921	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCAGGCTTTCCTCTTTCTCCG	0.512000													20	60					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216296644	216296644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:216296644G>A	ENST00000354785.4	-	4	828	c.459C>T	c.(457-459)acC>acT	p.T153T	FN1_ENST00000421182.1_Silent_p.T153T|FN1_ENST00000446046.1_Silent_p.T153T|FN1_ENST00000359671.1_Silent_p.T153T|FN1_ENST00000357867.4_Silent_p.T153T|FN1_ENST00000357009.2_Silent_p.T153T|FN1_ENST00000356005.4_Silent_p.T153T|FN1_ENST00000346544.3_Silent_p.T153T|FN1_ENST00000443816.1_Silent_p.T153T|FN1_ENST00000336916.4_Silent_p.T153T|FN1_ENST00000323926.6_Silent_p.T153T|FN1_ENST00000432072.2_Silent_p.T153T|FN1_ENST00000426059.1_Silent_p.T153T|FN1_ENST00000345488.5_Silent_p.T153T			P02751	FINC_HUMAN	fibronectin 1	153	Fibrin- and heparin-binding 1.|Fibronectin type-I 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCTCCTCCAGGTGTCACCAA	0.463000													11	179					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	93225885	93225885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:93225885C>T	ENST00000282020.4	+	1	336	c.78C>T	c.(76-78)atC>atT	p.I26I	GRID2_ENST00000510992.1_Silent_p.I26I|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	26					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CGGATTCGATCATTCACATCG	0.502000													19	51					0	0	1	0	0
DOLPP1	57171	broad.mit.edu	37	9	131847378	131847378	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131847378C>T	ENST00000372546.4	+	3	286	c.254C>T	c.(253-255)cCc>cTc	p.P85L	DOLPP1_ENST00000540102.1_Intron|DOLPP1_ENST00000406974.3_Missense_Mutation_p.P85L	NM_020438.4	NP_065171.2	Q86YN1	DOPP1_HUMAN	dolichyldiphosphatase 1	85					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			endometrium(3)|kidney(2)|lung(7)|skin(1)	13						GAGCCACGGCCCTGTGGAGGT	0.632000													8	48					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56387438	56387438	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56387438G>A	ENST00000355701.3	-	21	4651	c.3781C>T	c.(3781-3783)Cag>Tag	p.Q1261*	BZRAP1_ENST00000268893.6_Nonsense_Mutation_p.Q1201*|BZRAP1_ENST00000343736.4_Nonsense_Mutation_p.Q1261*	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1261						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tcttcctcctGGATGTCTGAC	0.572000													36	59					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770252	53770252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53770252G>A	ENST00000311170.4	-	1	720	c.667C>T	c.(667-669)Ccc>Tcc	p.P223S		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	223					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GAGGCTCTGGGGGAGAGATTG	0.537000										HNSCC(26;0.072)			8	18					0	0	1	0	0
WDR92	116143	broad.mit.edu	37	2	68358422	68358422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:68358422G>A	ENST00000295121.6	-	8	1138	c.1022C>T	c.(1021-1023)tCa>tTa	p.S341L	WDR92_ENST00000492039.2_5'UTR	NM_138458.3	NP_612467.1	Q96MX6	WDR92_HUMAN	WD repeat domain 92	341					apoptosis|histone lysine methylation		methylated histone residue binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|stomach(1)	12						TTGGTCAAATGAACTACAGAC	0.463000													44	154					0	0	1	0	0
OTOP2	92736	broad.mit.edu	37	17	72926672	72926672	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72926672G>A	ENST00000331427.4	+	6	1034	c.942G>A	c.(940-942)gtG>gtA	p.V314V	OTOP2_ENST00000580223.1_Silent_p.V314V	NM_178160.2	NP_835454.1	Q7RTS6	OTOP2_HUMAN	otopetrin 2	314						integral to membrane				breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|prostate(4)|skin(1)|urinary_tract(2)	39	all_lung(278;0.172)|Lung NSC(278;0.207)					AGGTTCAAGTGAGCGGGGACG	0.602000													7	37					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74698746	74698746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:74698746G>A	ENST00000541184.1	-	2	688	c.211C>T	c.(211-213)Cca>Tca	p.P71S	ZDHHC15_ENST00000373361.3_Missense_Mutation_p.P80S|ZDHHC15_ENST00000373367.3_Missense_Mutation_p.P80S	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	80						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						GGCTGCTGTGGGAGTGTAAAG	0.348000													13	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179497405	179497405	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179497405C>T	ENST00000589042.1	-	235	43552	c.43328G>A	c.(43327-43329)gGa>gAa	p.G14443E	TTN_ENST00000342992.6_Missense_Mutation_p.G11875E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G5378E|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G5570E|TTN_ENST00000359218.5_Missense_Mutation_p.G5503E|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G12802E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12802	Fibronectin type-III 4.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCTGGGTTCCTTTTAGCCA	0.418000													55	144					0	0	1	0	0
DYRK1A	1859	broad.mit.edu	37	21	38884476	38884476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38884476C>T	ENST00000339659.3	+	11	3377	c.1907C>T	c.(1906-1908)tCt>tTt	p.S636F	DYRK1A_ENST00000338785.3_3'UTR|DYRK1A_ENST00000455387.2_Missense_Mutation_p.S417F|DYRK1A_ENST00000398960.2_Missense_Mutation_p.S645F	NM_130436.2	NP_569120.1	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	645					nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			breast(4)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						ACCCAAGATTCTATGGAGGTT	0.522000													27	63					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138687872	138687872	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:138687872C>T	ENST00000520602.1	-	16	2022	c.1737_splice	c.e16+1	p.L579_splice	MCF2_ENST00000338585.6_Splice_Site_p.L535_splice|MCF2_ENST00000519895.1_Splice_Site_p.L595_splice|MCF2_ENST00000370576.4_Splice_Site_p.L519_splice|MCF2_ENST00000536274.1_Splice_Site_p.L480_splice|MCF2_ENST00000414978.1_Splice_Site_p.L579_splice|MCF2_ENST00000370578.4_Splice_Site_p.L664_splice|MCF2_ENST00000370573.4_Splice_Site_p.L519_splice			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	519	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					AGTCGCTTACCAACAAAACAG	0.363000													83	63					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137777709	137777709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137777709G>A	ENST00000350339.2	+	5	425	c.411G>A	c.(409-411)ctG>ctA	p.L137L	FCN2_ENST00000291744.6_Silent_p.L175L	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	175	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding	p.L175L(1)		breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		AGTTCTGGCTGGGGAATGACA	0.672000													20	42					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117885050	117885050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:117885050C>T	ENST00000439649.3	-	5	804	c.437G>A	c.(436-438)gGg>gAg	p.G146E	GFRA1_ENST00000369236.1_Missense_Mutation_p.G146E|GFRA1_ENST00000544592.1_Missense_Mutation_p.G30E|GFRA1_ENST00000355422.6_Missense_Mutation_p.G151E	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	151					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		GCAGTTGTTCCCTTTGGGAAT	0.537000													6	14					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127253129	127253129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127253129C>T	ENST00000341640.2	-	6	843	c.638G>A	c.(637-639)aGa>aAa	p.R213K	PAX4_ENST00000463946.1_Missense_Mutation_p.R211K|PAX4_ENST00000338516.3_Missense_Mutation_p.R221K|PAX4_ENST00000378740.2_Missense_Mutation_p.R213K	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	221					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						TTTGGCTCTTCTGTTGGAAAA	0.527000													12	61					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71348651	71348651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:71348651C>T	ENST00000392650.3	-	41	5719	c.5719G>A	c.(5719-5721)Ggt>Agt	p.G1907S	SDK2_ENST00000410094.1_5'UTR|SDK2_ENST00000388726.3_Missense_Mutation_p.G1888S	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1907	Fibronectin type-III 13.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GTGCCGAAACCATAGTCGTTG	0.637000													4	21					0	0	1	0	0
TCP11	6954	broad.mit.edu	37	6	35086057	35086057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35086057C>T	ENST00000311875.5	-	10	1957	c.1540G>A	c.(1540-1542)Gag>Aag	p.E514K	TCP11_ENST00000244645.3_Missense_Mutation_p.E439K|TCP11_ENST00000373974.4_Missense_Mutation_p.E468K|TCP11_ENST00000512012.1_Missense_Mutation_p.E501K|TCP11_ENST00000418521.2_Missense_Mutation_p.E438K|TCP11_ENST00000373979.2_Missense_Mutation_p.E439K|TCP11_ENST00000412155.2_Missense_Mutation_p.E463K|TCP11_ENST00000444780.2_Missense_Mutation_p.E509K			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	501					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						CAAACAGACTCCACTTTTGTT	0.512000													11	109					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102071146	102071146	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102071146A>T	ENST00000549145.1	+	27	3201	c.3101A>T	c.(3100-3102)aAa>aTa	p.K1034I	MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000361466.2_Missense_Mutation_p.K1028I|MYBPC1_ENST00000360610.2_Missense_Mutation_p.K1021I|MYBPC1_ENST00000550270.1_Missense_Mutation_p.K1021I|MYBPC1_ENST00000547509.1_Missense_Mutation_p.K989I|MYBPC1_ENST00000547405.1_Missense_Mutation_p.K977I|MYBPC1_ENST00000545503.2_Missense_Mutation_p.K1003I|MYBPC1_ENST00000541119.1_Missense_Mutation_p.K991I|MYBPC1_ENST00000536007.1_Missense_Mutation_p.K984I|MYBPC1_ENST00000452455.2_Missense_Mutation_p.K1021I|MYBPC1_ENST00000392934.3_Missense_Mutation_p.K990I|MYBPC1_ENST00000361685.2_Missense_Mutation_p.K1028I|MYBPC1_ENST00000441232.1_Missense_Mutation_p.K1021I|MYBPC1_ENST00000551300.1_Missense_Mutation_p.K904I|MYBPC1_ENST00000553190.1_Missense_Mutation_p.K1003I			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	1021					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						ACCATGACTAAAGAGAGTGCA	0.458000													14	30					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57641153	57641153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57641153G>A	ENST00000254181.4	+	4	1564	c.1110G>A	c.(1108-1110)caG>caA	p.Q370Q	USP29_ENST00000598197.1_Silent_p.Q370Q	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	370					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCAACATGCAGAATGATGCTC	0.358000													35	85					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49248976	49248976	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49248976C>T	ENST00000332955.2	-	2	688	c.141G>A	c.(139-141)gcG>gcA	p.A47A		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	47					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TGTGATGCTTCGCATCCAGGT	0.532000													47	106					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76712680	76712680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76712680C>T	ENST00000369950.3	-	12	1435	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	416					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AGCTGGGGTTCAACAGGAGGA	0.428000													5	46					0	0	1	0	0
PRR23C	389152	broad.mit.edu	37	3	138763135	138763135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:138763135C>T	ENST00000413199.1	-	1	599	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	PRR23C_ENST00000502927.2_Missense_Mutation_p.E110K|MRPS22_ENST00000495075.1_Intron	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	110										breast(2)|lung(7)|skin(2)	11						CCTGAGCATTCGTCGACGGAG	0.647000													4	7					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48269424	48269424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48269424C>T	ENST00000435803.1	+	7	659	c.635C>T	c.(634-636)tCc>tTc	p.S212F		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	212					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGTTCTAGTTCCTTAATATCC	0.388000													76	185					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9371224	9371224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9371224G>A	ENST00000378501.2	+	14	1300	c.1285G>A	c.(1285-1287)Ggg>Agg	p.G429R	PLCB4_ENST00000414679.2_Missense_Mutation_p.G429R|PLCB4_ENST00000378493.1_Missense_Mutation_p.G429R|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.G429R|PLCB4_ENST00000378473.3_Missense_Mutation_p.G429R|PLCB4_ENST00000334005.3_Missense_Mutation_p.G429R	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	429	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AGATCTATTTGGGGATCTCCT	0.343000													15	31					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102951139	102951139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:102951139G>A	ENST00000504592.1	+	14	1990	c.1572G>A	c.(1570-1572)atG>atA	p.M524I	BANK1_ENST00000322953.4_Missense_Mutation_p.M539I|BANK1_ENST00000508653.1_Missense_Mutation_p.M406I|RP11-498M5.2_ENST00000505091.1_RNA|BANK1_ENST00000510950.1_3'UTR|BANK1_ENST00000428908.1_Missense_Mutation_p.M406I|BANK1_ENST00000444316.2_Missense_Mutation_p.M509I			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	539					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AAGGCCAAATGGAAAGAAGTC	0.398000													28	72					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78796447	78796447	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78796447C>T	ENST00000545128.1	+	16	2675	c.2137C>T	c.(2137-2139)Ctg>Ttg	p.L713L	PCSK5_ENST00000376752.4_Silent_p.L713L	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	713	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TGGATACTTTCTGAATGAAGA	0.478000													37	79					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43067772	43067772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43067772G>A	ENST00000267890.6	-	13	1667	c.1559C>T	c.(1558-1560)tCt>tTt	p.S520F		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	520					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		GGTGTTGGCAGAAGCAGGCTT	0.502000													33	90					0	0	1	0	0
PHF2	5253	broad.mit.edu	37	9	96420455	96420455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96420455C>T	ENST00000359246.4	+	10	1543	c.1176C>T	c.(1174-1176)ccC>ccT	p.P392P	PHF2_ENST00000375376.4_Intron	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	392					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		AGCAGCTGCCCCCTCATCTAG	0.557000													4	24					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980844	40980844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40980844C>T	ENST00000373198.3	-	10	1877	c.1642G>A	c.(1642-1644)Gaa>Aaa	p.E548K	PTPRT_ENST00000373193.3_Missense_Mutation_p.E548K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E548K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E548K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E548K|PTPRT_ENST00000373187.1_Missense_Mutation_p.E548K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E548K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	548	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGTGGGTTTCATTCCGGAGC	0.572000													10	104					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73462885	73462885	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73462885C>T	ENST00000252034.7	+	15	1197	c.799_splice	c.e15+1	p.F266_splice	ELN_ENST00000380553.4_Splice_Site_p.F149_splice|ELN_ENST00000380562.4_Splice_Site_p.F266_splice|ELN_ENST00000358929.4_Splice_Site_p.F266_splice|ELN_ENST00000414324.1_Splice_Site_p.F261_splice|ELN_ENST00000320399.6_Splice_Site_p.F266_splice|ELN_ENST00000429192.1_Splice_Site_p.F271_splice|ELN_ENST00000380584.4_Splice_Site_p.F252_splice|ELN_ENST00000445912.1_Splice_Site_p.F266_splice|ELN_ENST00000458204.1_Splice_Site_p.F256_splice|ELN_ENST00000357036.5_Splice_Site_p.F271_splice|ELN_ENST00000380576.5_Splice_Site_p.F266_splice|ELN_ENST00000320492.7_Splice_Site_p.F230_splice|ELN_ENST00000380575.4_Splice_Site_p.F256_splice	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	266	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding	p.F266F(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	cagcaAAGTTCGGTGAGTGCC	0.607000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						5	65					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79193782	79193782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79193782G>A	ENST00000269392.4	-	2	322	c.75C>T	c.(73-75)ctC>ctT	p.L25L	AZI1_ENST00000374782.3_Silent_p.L25L|AZI1_ENST00000575907.1_Silent_p.L25L|AZI1_ENST00000450824.2_Silent_p.L25L	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	25					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CAGGCGGAGGGAGACCTGTCA	0.677000													23	65					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205554035	205554035	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205554035G>A	ENST00000367147.4	+	5	984	c.891G>A	c.(889-891)agG>agA	p.R297R	MFSD4_ENST00000539267.1_Silent_p.R297R|MFSD4_ENST00000536357.1_Silent_p.R210R	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	297					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GCTGCCAAAGGAAGAACCTCA	0.587000											OREG0014158	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	138					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139424	90139424	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90139424C>T	ENST00000492446.1	+	0	222																											CAGAGAAAGCCCCTAAGTCCC	0.522000													43	231					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52586576	52586576	+	Missense_Mutation	SNP	G	G	A	rs144206846	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52586576G>A	ENST00000591504.1	-	9	989	c.715C>T	c.(715-717)Ctc>Ttc	p.L239F	CCDC68_ENST00000432185.1_Missense_Mutation_p.L239F|CCDC68_ENST00000337363.4_Missense_Mutation_p.L239F	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	239										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TGCTCCTGGAGAATGGAAATC	0.453000													26	73					0	0	1	0	0
GNLY	10578	broad.mit.edu	37	2	85924772	85924772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:85924772G>A	ENST00000409696.3	+	5	636	c.354G>A	c.(352-354)gaG>gaA	p.E118E	GNLY_ENST00000524600.1_Silent_p.E160E|GNLY_ENST00000263863.4_Silent_p.E133E	NM_012483.2	NP_036615.2	P22749	GNLY_HUMAN	granulysin	133	Saposin B-type.				cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space		p.E133E(1)		endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						AGATCTGTGAGGACCTCAGGT	0.542000													4	45					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149503946	149503946	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149503946C>T	ENST00000378016.2	+	0	8770							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTTCTGCGCCCCCGGCTGCAC	0.662000													5	12					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45028281	45028281	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45028281G>A	ENST00000454753.1	-	0	488							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				CTGCAATGGAGGGTTTGGCCA	0.522000													11	51					0	0	1	0	0
FAR2P1	440905	broad.mit.edu	37	2	130792786	130792786	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130792786C>T	ENST00000325390.3	-	0	2542					NR_026758.1																						AATTAAGTCTCCCACAGCCAT	0.468000													19	30					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57080136	57080136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57080136G>A	ENST00000532437.1	-	4	2337	c.2026C>T	c.(2026-2028)Cca>Tca	p.P676S	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.P676S			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	676	Acidic.|Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				TCAGGGCCTGGAGGCTCGGGG	0.662000													20	46					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153476190	153476190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:153476190G>A	ENST00000288670.9	+	15	2162	c.1795G>A	c.(1795-1797)Gga>Aga	p.G599R	FMNL2_ENST00000475377.2_5'UTR	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	599	Pro-rich.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						TCCGCTGCCTGGAACATCTTC	0.562000													10	22					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999796	112999796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112999796C>T	ENST00000271277.6	+	6	1907	c.1682C>T	c.(1681-1683)cCc>cTc	p.P561L	RP4-671G15.3_ENST00000508462.1_RNA|CTTNBP2NL_ENST00000607039.1_3'UTR	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	561						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCCTGAGCCCCCTGTCTCCA	0.557000													29	90					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076250	9076250	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9076250A>T	ENST00000397910.4	-	3	11399	c.11196T>A	c.(11194-11196)tcT>tcA	p.S3732S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3733	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGTGGACAGAGAATCAAACA	0.502000													20	84					0	0	1	0	0
GZMB	3002	broad.mit.edu	37	14	25101071	25101071	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:25101071G>A	ENST00000216341.4	-	4	699	c.593C>T	c.(592-594)tCc>tTc	p.S198F	GZMB_ENST00000415355.3_Missense_Mutation_p.S186F|GZMB_ENST00000526004.1_3'UTR|GZMB_ENST00000382542.1_Missense_Mutation_p.S232F|GZMB_ENST00000382540.1_Missense_Mutation_p.S153F|RP11-104E19.1_ENST00000555300.1_RNA|RP11-104E19.1_ENST00000557736.1_RNA			P10144	GRAB_HUMAN	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	198	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(4)|stomach(4)|urinary_tract(2)	13				GBM - Glioblastoma multiforme(265;0.028)		TACCTTAAAGGAAGTCTTTTT	0.473000													33	98					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47858339	47858339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47858339C>T	ENST00000328771.4	+	3	1098	c.749C>T	c.(748-750)aCc>aTc	p.T250I		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	250	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TCGGCGGCCACCAAGATTGTA	0.587000													17	94					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176905489	176905489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176905489C>T	ENST00000367654.2	-	15	2432	c.2419G>A	c.(2419-2421)Gaa>Aaa	p.E807K	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.E799K|ASTN1_ENST00000367657.3_Missense_Mutation_p.E799K|ASTN1_ENST00000361833.2_Missense_Mutation_p.E799K			O14525	ASTN1_HUMAN	astrotactin 1	807					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CCAGACACTTCACTGAAGTTC	0.488000													34	50					0	0	1	0	0
TRIM25	7706	broad.mit.edu	37	17	54972922	54972922	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54972922G>A	ENST00000316881.4	-	7	1273	c.1224C>T	c.(1222-1224)gcC>gcT	p.A408A	TRIM25_ENST00000537230.1_Silent_p.A408A	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	408	Interaction with influenza A virus NS1.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					ACTGTTCCGGGGCTCCAAACG	0.517000													18	181					0	0	1	0	0
CCKBR	887	broad.mit.edu	37	11	6291949	6291949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6291949C>T	ENST00000525462.1	+	4	730	c.727C>T	c.(727-729)Cgc>Tgc	p.R243C	CCKBR_ENST00000334619.2_Missense_Mutation_p.R243C|CCKBR_ENST00000532715.1_Missense_Mutation_p.R159C			P32239	GASR_HUMAN	cholecystokinin B receptor	201					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GCTTATCTCTCGCGAGCTCTA	0.597000													38	67					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93902842	93902842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:93902842G>A	ENST00000412050.4	-	6	1443	c.1355C>T	c.(1354-1356)cCt>cTt	p.P452L	CPEB3_ENST00000265997.4_Missense_Mutation_p.P466L	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	466	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				TACTACGAGAGGTCCAAACCT	0.398000													22	57					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94931643	94931643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94931643G>A	ENST00000222381.3	-	8	1014	c.783C>T	c.(781-783)tcC>tcT	p.S261S	PON1_ENST00000542556.1_Silent_p.S261S	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	261					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TAAAGTCAAGGGACTTAAAAG	0.378000													6	54					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141079606	141079606	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141079606G>A	ENST00000389484.3	-	82	13537	c.12566C>T	c.(12565-12567)cCt>cTt	p.P4189L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4189					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGCCCCAGAAGGATTTAGCAA	0.373000										TSP Lung(27;0.18)			15	60					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43259160	43259160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43259160G>A	ENST00000404209.4	-	4	1064	c.968C>T	c.(967-969)cCa>cTa	p.P323L	PSG8_ENST00000406636.3_Missense_Mutation_p.P201L|PSG8_ENST00000401467.2_Missense_Mutation_p.P230L|PSG8_ENST00000600709.1_Intron|PSG8_ENST00000306511.4_Missense_Mutation_p.P323L	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	323	Ig-like C2-type 2.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				CAGGGTGACTGGGTAACTGCG	0.478000													43	244					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012767	29012767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29012767G>A	ENST00000377175.1	-	1	250	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						AATTTCTGAGGAAAAAGTACA	0.433000													29	75					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49656793	49656793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49656793C>T	ENST00000252825.4	-	1	1888	c.1702G>A	c.(1702-1704)Gag>Aag	p.E568K	HRC_ENST00000595625.1_Missense_Mutation_p.E568K	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	568					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		tcttcctcctcGCTGTGGTCT	0.622000													10	12					0	0	1	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133953998	133953998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:133953998C>T	ENST00000298622.4	+	9	1526	c.1388C>T	c.(1387-1389)tCc>tTc	p.S463F		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GAAGAGGCTTCCCTGGAATCC	0.587000													8	26					0	0	1	0	0
ELAVL3	1995	broad.mit.edu	37	19	11577595	11577595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11577595G>A	ENST00000359227.3	-	2	481	c.57C>T	c.(55-57)ggC>ggT	p.G19G	CTC-398G3.6_ENST00000585656.1_Silent_p.G173G|ELAVL3_ENST00000438662.2_Silent_p.G19G	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	19					cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCAgggccgggccggccgggc	0.652000													9	29					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908493	164908493	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164908493C>T	ENST00000475390.1	-	2	569	c.126G>A	c.(124-126)gaG>gaA	p.E42E	SLITRK3_ENST00000241274.3_Silent_p.E42E			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	42						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CAAAACAGGGCTCATCTATTT	0.393000										HNSCC(40;0.11)			15	115					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2928182	2928182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:2928182C>T	ENST00000381130.2	+	2	204	c.204C>T	c.(202-204)ccC>ccT	p.P68P		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	68						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GCCGGTACCCCATCAGATCAG	0.483000													9	6					0	0	1	0	0
HEMGN	55363	broad.mit.edu	37	9	100692463	100692463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:100692463G>A	ENST00000259456.3	-	4	1357	c.1214C>T	c.(1213-1215)cCt>cTt	p.P405L		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	405					cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				GAGGTCTTCAGGCCCCGGTGT	0.433000													101	206					0	0	1	0	0
ADRA2C	152	broad.mit.edu	37	4	3769561	3769561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3769561G>A	ENST00000330055.5	+	1	1437	c.1228G>A	c.(1228-1230)Gag>Aag	p.E410K	ADRA2C_ENST00000509482.1_Intron	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	410					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CATCTGCCGCGAGGCCTGCCA	0.592000													18	26					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031688	79031688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79031688G>A	ENST00000446378.2	+	2	7131	c.7100G>A	c.(7099-7101)aGa>aAa	p.R2367K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2367						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAAGAGCCAAGAAGTGATCAA	0.368000													17	51					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141752717	141752717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141752717C>T	ENST00000475668.2	+	26	3146	c.3092C>T	c.(3091-3093)cCc>cTc	p.P1031L	MGAM_ENST00000549489.2_Missense_Mutation_p.P1031L			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1031					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AATGCCTTCCCCTCCACACCC	0.458000													20	70					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46656462	46656462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46656462C>T	ENST00000253255.5	-	1	2757	c.2758G>A	c.(2758-2760)Gat>Aat	p.D920N		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	920					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTTTCCTGATCATTTAACCAA	0.438000													69	159					0	0	1	0	0
BTN3A2	11118	broad.mit.edu	37	6	26368453	26368453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26368453C>T	ENST00000356386.2	+	3	231	c.43C>T	c.(43-45)Cat>Tat	p.H15Y	BTN3A2_ENST00000396934.3_Intron|BTN3A2_ENST00000527422.1_Missense_Mutation_p.H15Y|BTN3A2_ENST00000508906.2_Intron|BTN3A2_ENST00000532994.1_Intron|BTN3A2_ENST00000377708.2_Missense_Mutation_p.H15Y|BTN3A2_ENST00000396948.1_Missense_Mutation_p.H15Y	NM_001197246.2|NM_001197247.1|NM_007047.3	NP_001184175.1|NP_001184176.1|NP_008978.2	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2	15						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)	10						GCTCAACTTTCATGTCTCCCT	0.453000													53	105					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10941926	10941926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10941926G>A	ENST00000298232.7	-	13	1090	c.723C>T	c.(721-723)ttC>ttT	p.F241F	TPTE_ENST00000361285.4_Silent_p.F259F|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.F221F	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	259	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GATTTCTATAGAAAGACTGCC	0.313000													34	258					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49812809	49812809	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49812809C>T	ENST00000249601.4	-	1	329	c.34_splice	c.e1+1	p.R11_splice	ARHGAP22_ENST00000435790.2_Intron|ARHGAP22_ENST00000417912.2_Splice_Site_p.R11_splice|ARHGAP22_ENST00000491108.1_5'UTR	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	11					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TGGACTTACCCCTCCTGGCCT	0.612000													19	77					0	0	1	0	0
IL11	3589	broad.mit.edu	37	19	55877404	55877404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55877404C>T	ENST00000264563.2	-	5	633	c.571G>A	c.(571-573)Gga>Aga	p.G191R	IL11_ENST00000585513.1_Missense_Mutation_p.G191R|IL11_ENST00000590625.1_Missense_Mutation_p.G112R	NM_000641.3	NP_000632.1	P20809	IL11_HUMAN	interleukin 11	191					B cell differentiation|fat cell differentiation|megakaryocyte differentiation|negative regulation of hormone secretion|platelet activation|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity|growth factor activity|interleukin-11 receptor binding			large_intestine(1)|skin(1)	2	Breast(117;0.191)	Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)	Oprelvekin(DB00038)	AGCAGCAGTCCCCTCACGGCC	0.647000													7	11					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613737	179613737	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179613737C>T	ENST00000360870.5	-	46	13612	c.13390G>A	c.(13390-13392)Gaa>Aaa	p.E4464K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	592	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAATTTTTCAAATTCGATA	0.338000													22	69					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56226561	56226561	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56226561G>A	ENST00000332836.2	-	6	2388	c.2361C>T	c.(2359-2361)tcC>tcT	p.S787S		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	787						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TGGAGTCACAGGAGACAGAGG	0.512000													14	38					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133799148	133799148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133799148C>T	ENST00000372338.4	-	4	1074	c.832G>A	c.(832-834)Gac>Aac	p.D278N	FIBCD1_ENST00000253018.4_Missense_Mutation_p.D120N|FIBCD1_ENST00000448616.1_Missense_Mutation_p.D278N|FIBCD1_ENST00000372337.2_Missense_Mutation_p.D120N	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	278	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CCGCCGCCGTCCGTGCGCATG	0.672000													8	25					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48797262	48797262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48797262G>A	ENST00000316623.5	-	16	2375	c.1920C>T	c.(1918-1920)ttC>ttT	p.F640F		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	640	EGF-like 10; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCAGTCCAGGGAAGCATTCAC	0.502000													50	132					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6479870	6479870	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6479870C>T	ENST00000381480.2	-	3	238	c.126_splice	c.e3+1	p.Q42_splice	DENND1C_ENST00000543576.1_Intron|DENND1C_ENST00000591030.1_5'UTR	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	42	UDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GCCTGAATACCTGGTCCCTGA	0.652000													12	21					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33894000	33894000	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33894000C>T	ENST00000307296.3	+	13	2039	c.1662C>T	c.(1660-1662)tcC>tcT	p.S554S	PDCD6IP_ENST00000457054.2_Silent_p.S559S			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	554	Interaction with EIAV p9.|Self-association.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						TCTTAAAATCCTTATTGTCAA	0.303000													5	45					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179076997	179076997	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179076997G>A	ENST00000502732.1	-	12	3608	c.3405C>T	c.(3403-3405)gcC>gcT	p.A1135A	ABL2_ENST00000344730.3_Silent_p.A1017A|ABL2_ENST00000367623.4_Silent_p.A1114A|ABL2_ENST00000511413.1_Silent_p.A1032A|ABL2_ENST00000504405.1_Silent_p.A996A|ABL2_ENST00000512653.1_Silent_p.A1120A|ABL2_ENST00000507173.1_Silent_p.A1011A|ABL2_ENST00000408940.3_Silent_p.A1099A	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	1135	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CCTCTCGGAAGGCAAATTTGT	0.537000			T	ETV6	AML								29	44					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82644405	82644405	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:82644405C>T	ENST00000533655.1	+	6	2237	c.2025C>T	c.(2023-2025)gcC>gcT	p.A675A	C11orf82_ENST00000329143.3_Silent_p.A374A|C11orf82_ENST00000430323.2_Silent_p.A675A|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	675					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						GCTATGATGCCTCTGCTGATC	0.348000													58	194					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23865591	23865591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23865591C>T	ENST00000405093.3	-	20	2401	c.2331G>A	c.(2329-2331)gaG>gaA	p.E777E	MYH6_ENST00000356287.3_Silent_p.E777E	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	777	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CATCCCGCATCTCCTCCAGCA	0.607000													5	55					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121341592	121341592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121341592C>T	ENST00000338040.4	+	3	1730	c.1316C>T	c.(1315-1317)tCc>tTc	p.S439F		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	439					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GAACAGTTTTCCTCTGGGACA	0.522000													29	97					0	0	1	0	0
KRT16P2	400578	broad.mit.edu	37	17	16735731	16735731	+	RNA	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:16735731A>T	ENST00000579062.1	-	0	225																											GCCCACCAGAAGCccatcacc	0.637000													26	44					0	0	1	0	0
WNT11	7481	broad.mit.edu	37	11	75902850	75902850	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75902850G>A	ENST00000322563.3	-	4	772	c.648C>T	c.(646-648)ggC>ggT	p.G216G	RP11-619A14.2_ENST00000527314.1_RNA	NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	216					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						TGGAGCAGGAGCCAGACACCC	0.642000													18	51					0	0	1	0	0
DUOXA1	90527	broad.mit.edu	37	15	45411507	45411507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45411507G>A	ENST00000558996.1	-	6	748	c.694C>T	c.(694-696)Cac>Tac	p.H232Y	DUOXA1_ENST00000558422.1_Missense_Mutation_p.H232Y|DUOXA1_ENST00000267803.4_Missense_Mutation_p.H277Y|DUOXA1_ENST00000560572.1_Missense_Mutation_p.H277Y|DUOXA1_ENST00000559014.1_Missense_Mutation_p.H277Y|DUOXA1_ENST00000430224.2_Missense_Mutation_p.H232Y	NM_001276267.1|NM_001276268.1	NP_001263196.1|NP_001263197.1	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	277					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		TTCAGCCTGTGAGGCTGCATC	0.582000													12	46					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44804027	44804027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44804027C>T	ENST00000309315.4	+	14	1993	c.1870C>T	c.(1870-1872)Ctg>Ttg	p.L624L	ZMIZ2_ENST00000441627.1_Silent_p.L624L|ZMIZ2_ENST00000433667.1_Silent_p.L592L|ZMIZ2_ENST00000413916.1_Silent_p.L566L|ZMIZ2_ENST00000265346.7_Silent_p.L598L	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	624					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GTGCTTTGACCTGGAGTCGTA	0.527000													18	53					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	169930250	169930250	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169930250G>A	ENST00000367765.1	-	18	3491	c.1990C>T	c.(1990-1992)Cga>Tga	p.R664*	KIFAP3_ENST00000367767.1_Nonsense_Mutation_p.R660*|KIFAP3_ENST00000540905.1_Nonsense_Mutation_p.R406*|KIFAP3_ENST00000361580.2_Nonsense_Mutation_p.R704*|KIFAP3_ENST00000538366.1_Nonsense_Mutation_p.R626*	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	704					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding	p.R704*(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGCTCAATTCGATCATCACCA	0.408000													36	67					0	0	1	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242742894	242742894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242742894C>T	ENST00000192314.6	+	4	641	c.510C>T	c.(508-510)ttC>ttT	p.F170F		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	170					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TGGACGCGTTCCTGGCCTCGC	0.627000													7	15					0	0	1	0	0
SUCNR1	56670	broad.mit.edu	37	3	151599232	151599232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151599232C>T	ENST00000362032.4	+	3	1006	c.901C>T	c.(901-903)Cac>Tac	p.H301Y	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_033050.4	NP_149039.2	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	301						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	TTTGGGAGATCACTTCAGGGA	0.433000													46	108					0	0	1	0	0
RBM28	55131	broad.mit.edu	37	7	127954827	127954827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127954827G>A	ENST00000223073.1	-	17	2149	c.2035C>T	c.(2035-2037)Ccc>Tcc	p.P679S	RBM28_ENST00000415472.2_Missense_Mutation_p.P538S|RBM28_ENST00000481788.1_5'UTR	NM_018077.2	NP_060547.2	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	679					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			breast(1)|kidney(7)|large_intestine(3)|lung(8)|ovary(2)	21						CTGATTTTGGGGCCTCGGTGT	0.532000													79	259					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929987	121929987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:121929987C>T	ENST00000265922.3	-	8	2122	c.1661G>A	c.(1660-1662)aGc>aAc	p.S554N	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		554					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GTCCAGGCTGCTGTTGCGCAT	0.567000													10	34					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37603671	37603671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37603671C>T	ENST00000328544.3	-	2	705	c.172G>A	c.(172-174)Ggc>Agc	p.G58S	SSTR3_ENST00000402501.1_Missense_Mutation_p.G58S	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	58					G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						CCCAGCAGGCCCACCACGCAC	0.657000													40	105					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38230103	38230103	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38230103T>C	ENST00000339503.4	-	8	1615	c.1114A>G	c.(1114-1116)Aaa>Gaa	p.K372E	ZNF573_ENST00000536220.1_Missense_Mutation_p.K342E|ZNF573_ENST00000392138.1_Missense_Mutation_p.K343E|ZNF573_ENST00000357309.3_Missense_Mutation_p.K342E|ZNF573_ENST00000590414.2_Missense_Mutation_p.K430E	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TGATGTTGTTTAAGGTAGCCA	0.358000													73	179					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24689314	24689314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:24689314C>T	ENST00000396475.2	+	5	653	c.354C>T	c.(352-354)atC>atT	p.I118I	MPP6_ENST00000222644.4_Silent_p.I118I|MPP6_ENST00000409761.1_Silent_p.I6I	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	118					protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						ATTCTTCTATCAATAATCAGT	0.378000													29	83					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169512260	169512260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169512260C>T	ENST00000367796.3	-	13	2284	c.2083G>A	c.(2083-2085)Gaa>Aaa	p.E695K	F5_ENST00000367797.3_Missense_Mutation_p.E690K			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	690	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TATGAGTCTTCATCATCATCT	0.393000													43	170					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38530995	38530995	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38530995C>T	ENST00000332509.3	-	6	1077	c.894_splice	c.e6+1	p.E298_splice	PLA2G6_ENST00000402064.1_Splice_Site_p.E298_splice|PLA2G6_ENST00000335539.3_Splice_Site_p.E298_splice	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	298					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	ATCCACTCACCTCTGCGTTCT	0.662000													11	40					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66905896	66905896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:66905896G>A	ENST00000374690.3	+	3	2337	c.1813G>A	c.(1813-1815)Gat>Aat	p.D605N	AR_ENST00000513847.1_3'UTR|AR_ENST00000396043.2_Missense_Mutation_p.D73N|AR_ENST00000396044.3_Missense_Mutation_p.D605N|AR_ENST00000504326.1_Missense_Mutation_p.D605N	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	604	Interaction with HIPK3 (By similarity).				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TTGCACTATTGATAAATTCCG	0.413000									Androgen Insensitivity Syndrome				29	16					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130408766	130408766	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130408766G>A	ENST00000370904.1	-	24	4441	c.3531C>T	c.(3529-3531)ccC>ccT	p.P1177P	IGSF1_ENST00000370903.3_Silent_p.P1191P|IGSF1_ENST00000370910.1_Silent_p.P1177P|IGSF1_ENST00000361420.3_Silent_p.P1186P			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1186	Ig-like C2-type 12.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						CACCTGGCAGGGGTCCTCGGC	0.502000													88	57					0	0	1	0	0
GBP7	388646	broad.mit.edu	37	1	89618032	89618032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89618032C>T	ENST00000294671.2	-	5	682	c.544G>A	c.(544-546)Gat>Aat	p.D182N		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	182						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		AGGGTAAAATCTCGAACAGTC	0.468000													31	154					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136268834	136268834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136268834G>A	ENST00000371957.3	+	15	1592	c.1485G>A	c.(1483-1485)gtG>gtA	p.V495V	C9orf96_ENST00000371955.1_Silent_p.V28V	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	495							ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GTATCATTGTGAACAAGGCCC	0.617000													8	19					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71908145	71908145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71908145G>A	ENST00000258104.3	+	53	6238	c.5961G>A	c.(5959-5961)atG>atA	p.M1987I	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Missense_Mutation_p.M1988I|DYSF_ENST00000409744.1_Missense_Mutation_p.M1995I|DYSF_ENST00000410020.3_Missense_Mutation_p.M2026I|DYSF_ENST00000413539.2_Missense_Mutation_p.M2018I|DYSF_ENST00000429174.2_Missense_Mutation_p.M2008I|DYSF_ENST00000409366.1_Missense_Mutation_p.M2009I|DYSF_ENST00000409582.3_Missense_Mutation_p.M2025I|DYSF_ENST00000409762.1_Missense_Mutation_p.M2004I|DYSF_ENST00000409651.1_Missense_Mutation_p.M2019I|DYSF_ENST00000410041.1_Missense_Mutation_p.M2005I	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1987						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						AGCTGGAAATGACCTTGGAGA	0.572000													6	26					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526272	176526272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176526272C>T	ENST00000367662.3	+	2	1978	c.814C>T	c.(814-816)Ctg>Ttg	p.L272L	PAPPA2_ENST00000367661.3_Silent_p.L272L	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	272					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GCGGGAGCGGCTGCTGCTGCG	0.567000													12	38					0	0	1	0	0
FBXO3	26273	broad.mit.edu	37	11	33777415	33777415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:33777415G>A	ENST00000530401.1	-	5	585	c.565C>T	c.(565-567)Ctc>Ttc	p.L189F	FBXO3_ENST00000526785.1_Missense_Mutation_p.L81F|FBXO3_ENST00000265651.3_Missense_Mutation_p.L194F|FBXO3_ENST00000534136.1_Missense_Mutation_p.L194F|FBXO3_ENST00000448981.2_Missense_Mutation_p.L194F			Q9UK99	FBX3_HUMAN	F-box protein 3	194					proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		GTTAAAGGGAGACAGTATTTC	0.448000													30	38					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210187104	210187104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210187104C>T	ENST00000537238.1	+	4	465	c.74C>T	c.(73-75)tCa>tTa	p.S25L	SYT14_ENST00000367015.1_Missense_Mutation_p.S25L|SYT14_ENST00000367019.1_Missense_Mutation_p.S63L|SYT14_ENST00000534859.1_Missense_Mutation_p.S63L|SYT14_ENST00000399639.2_Missense_Mutation_p.S63L|SYT14_ENST00000422431.1_Missense_Mutation_p.S108L|SYT14_ENST00000472886.1_Missense_Mutation_p.S63L|SYT14_ENST00000271745.7_3'UTR	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	63						integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		GATCTTGGTTCAGAATACAGT	0.328000													43	126					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118374328	118374328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118374328C>T	ENST00000534358.1	+	27	7744	c.7721C>T	c.(7720-7722)gCc>gTc	p.A2574V	KMT2A_ENST00000389506.5_Missense_Mutation_p.A2571V|KMT2A_ENST00000354520.4_Missense_Mutation_p.A2533V	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGTCCAGTGGCCCAACCAAGC	0.473000													19	68					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373565	126373565	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126373565G>A	ENST00000394329.3	+	9	11407	c.11394G>A	c.(11392-11394)gtG>gtA	p.V3798V	FAT4_ENST00000335110.5_Silent_p.V2096V	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3798					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GAGTAAAGGTGGAATCTGTGG	0.483000													11	54					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	122075631	122075631	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:122075631C>T	ENST00000265922.3	-	2	464	c.3G>A	c.(1-3)atG>atA	p.M1I	DBC1_ENST00000373964.2_Start_Codon_SNP_p.M1I	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		1					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						ACCTCCAGTTCATGCTTTTCT	0.453000													10	38					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70974910	70974910	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70974910G>A	ENST00000334414.6	-	10	2528	c.2484C>T	c.(2482-2484)ttC>ttT	p.F828F	PTPRB_ENST00000550857.1_Silent_p.F520F|PTPRB_ENST00000451516.2_Silent_p.F520F|PTPRB_ENST00000551525.1_Silent_p.F827F|PTPRB_ENST00000550358.1_Silent_p.F828F|PTPRB_ENST00000538708.1_Silent_p.F610F|PTPRB_ENST00000261266.5_Silent_p.F610F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	610	Fibronectin type-III 10.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGAGAGAGTGGAAGCTGTATC	0.473000													49	113					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047038	42047038	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42047038G>A	ENST00000372584.1	-	3	4445	c.3431C>T	c.(3430-3432)tCc>tTc	p.S1144F	HIVEP3_ENST00000247584.5_Missense_Mutation_p.S1144F|HIVEP3_ENST00000372583.1_Missense_Mutation_p.S1144F|HIVEP3_ENST00000429157.2_Missense_Mutation_p.S1144F	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1144					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGAGAAAAGGGAGACTGGTGG	0.587000													50	110					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71341895	71341895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71341895C>T	ENST00000260382.5	+	16	2265	c.2005C>T	c.(2005-2007)Cgc>Tgc	p.R669C	LRRC49_ENST00000560369.1_Missense_Mutation_p.R674C|LRRC49_ENST00000544974.2_Missense_Mutation_p.R659C|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000443425.2_Missense_Mutation_p.R625C|LRRC49_ENST00000560691.1_Missense_Mutation_p.R375C|LRRC49_ENST00000560158.2_Missense_Mutation_p.R357C	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	669						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						CATAGAAATTCGCAATAAAAA	0.368000													9	183					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	13959964	13959964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:13959964C>T	ENST00000382080.1	-	7	1380	c.665G>A	c.(664-666)gGg>gAg	p.G222E	SGCZ_ENST00000421524.2_Missense_Mutation_p.G175E	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	209					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CACCTGGACCCCACGGGGAGC	0.463000													7	38					0	0	1	0	0
IL36B	27177	broad.mit.edu	37	2	113788732	113788732	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113788732C>T	ENST00000259213.4	-	3	121	c.13_splice	c.e3-1	p.R5_splice	IL36B_ENST00000327407.2_Splice_Site_p.R5_splice	NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	5					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						TGCTGCCTCCCCTGCCAGATG	0.458000													16	34					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94049590	94049590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94049590G>A	ENST00000297268.6	+	35	2596	c.2125G>A	c.(2125-2127)Gga>Aga	p.G709R		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	709			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	tggtcctCGGGGAAGCCCTGT	0.453000										HNSCC(75;0.22)			12	99					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124515299	124515299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124515299G>A	ENST00000296181.4	-	10	1925	c.1629C>T	c.(1627-1629)atC>atT	p.I543I	ITGB5_ENST00000488466.1_5'UTR	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	543	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		AAGGCCCATAGATCTTGCCAA	0.587000													18	124					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3729188	3729188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3729188G>A	ENST00000315677.3	-	7	2133	c.1538C>T	c.(1537-1539)tCg>tTg	p.S513L	DLGAP1_ENST00000478161.1_5'UTR|DLGAP1_ENST00000584874.1_Missense_Mutation_p.S513L|DLGAP1_ENST00000581527.1_Missense_Mutation_p.S513L|DLGAP1_ENST00000581699.1_Missense_Mutation_p.S219L|DLGAP1_ENST00000515196.2_Missense_Mutation_p.S513L|DLGAP1_ENST00000539435.1_Missense_Mutation_p.S211L|DLGAP1_ENST00000400145.2_Missense_Mutation_p.S211L|DLGAP1_ENST00000400150.3_Missense_Mutation_p.S219L|DLGAP1_ENST00000400155.1_Missense_Mutation_p.S219L|DLGAP1_ENST00000400147.2_Missense_Mutation_p.S211L|DLGAP1_ENST00000400149.3_Missense_Mutation_p.S221L|DLGAP1_ENST00000534970.1_Missense_Mutation_p.S225L	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	513					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CGGCGAGGACGACCTCAGGGA	0.682000													12	42					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32261345	32261345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32261345C>T	ENST00000375015.4	-	26	1302	c.1102G>A	c.(1102-1104)Gag>Aag	p.E368K	C6orf10_ENST00000442822.2_Missense_Mutation_p.E360K|C6orf10_ENST00000527965.1_Missense_Mutation_p.E353K|C6orf10_ENST00000375007.4_Missense_Mutation_p.E367K|C6orf10_ENST00000533191.1_Missense_Mutation_p.E367K|C6orf10_ENST00000447241.2_Missense_Mutation_p.E369K			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	369						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						TCACTCTTCTCTACCTGGGCT	0.493000													68	198					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576383	33576383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33576383G>A	ENST00000504830.1	-	19	4083	c.3748C>T	c.(3748-3750)Cct>Tct	p.P1250S	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.P1165S	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1250	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CCTCCCAGAGGGAGCAGAGTG	0.522000										HNSCC(64;0.19)			48	144					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53041993	53041993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53041993C>T	ENST00000309680.3	-	5	1107	c.1086G>A	c.(1084-1086)agG>agA	p.R362R		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	362	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CTTCCTTGCTCCTCTGGGCGA	0.582000													53	113					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356289	37356289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:37356289C>T	ENST00000217420.1	+	2	848	c.585C>T	c.(583-585)gcC>gcT	p.A195A		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	195					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CCTGCTGCGCCCCGCGCTTCC	0.637000													15	36					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11676363	11676363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:11676363C>T	ENST00000423059.3	-	2	667	c.416G>A	c.(415-417)aGc>aAc	p.S139N	THSD7A_ENST00000480061.1_5'UTR	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	139						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTTCTCTAGGCTTTTTGAAAT	0.458000										HNSCC(18;0.044)			21	54					0	0	1	0	0
C12orf36	283422	broad.mit.edu	37	12	13529186	13529186	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13529186G>A	ENST00000318426.2	-	2	371	c.154C>T	c.(154-156)Ctg>Ttg	p.L52L	C12orf36_ENST00000531049.1_5'UTR|C12orf36_ENST00000527705.2_Silent_p.L52L|C12orf36_ENST00000539026.1_Silent_p.L52L|C12orf36_ENST00000532841.1_Silent_p.L52L					chromosome 12 open reading frame 36											lung(3)|skin(3)	6				BRCA - Breast invasive adenocarcinoma(232;0.198)		cctccAAGCAGGTCAGAGAAC	0.498000													20	77					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5283101	5283101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5283101G>A	ENST00000546004.1	-	3	986	c.740C>T	c.(739-741)tCc>tTc	p.S247F	PROKR2_ENST00000217270.3_Missense_Mutation_p.S247F			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	247						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GAGCTCCCGGGAGATCCTGGC	0.582000										HNSCC(71;0.22)			25	60					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110835726	110835726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110835726G>A	ENST00000296632.3	-	6	610	c.476C>T	c.(475-477)cCa>cTa	p.P159L	STARD4_ENST00000512160.1_3'UTR	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	159	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		GTCTTTAAGTGGAACACAAAA	0.413000													34	79					0	0	1	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114450762	114450762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114450762C>T	ENST00000369563.3	+	3	933	c.487C>T	c.(487-489)Cac>Tac	p.H163Y	DCLRE1B_ENST00000466480.1_3'UTR	NM_022836.3	NP_073747.1	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B	163					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(6)|stomach(1)	18	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAAGCTGCCCACCAGATTGT	0.463000								Other identified genes with known or suspected DNA repair function					33	102					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24251645	24251645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24251645G>A	ENST00000538205.1	+	5	658	c.111G>A	c.(109-111)acG>acA	p.T37T	ADAMDEC1_ENST00000522298.1_Silent_p.T37T|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000256412.4_Silent_p.T116T	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	116					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		AAATTACCACGAAACCTGAGA	0.458000													19	39					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45134815	45134815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45134815C>T	ENST00000296129.1	-	6	1715	c.1581G>A	c.(1579-1581)gaG>gaA	p.E527E		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	527	CUB.					extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GCCTGGAGGCCTCTTGTTGGA	0.527000													32	73					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27877351	27877351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27877351G>A	ENST00000374011.2	-	6	2244	c.1276C>T	c.(1276-1278)Ctg>Ttg	p.L426L	AHDC1_ENST00000247087.5_Silent_p.L426L|AHDC1_ENST00000482400.2_Intron	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	426	Pro-rich.						DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GGTTCGGCCAGGGCAGCCACC	0.726000													4	10					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21687043	21687043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:21687043C>T	ENST00000444366.2	+	1	183	c.182C>T	c.(181-183)cCc>cTc	p.P61L	PAX1_ENST00000398485.2_Intron|PAX1_ENST00000460221.1_Intron			P15863	PAX1_HUMAN	paired box 1	84					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						GTTTTCTCCCCCTCCGGCTCA	0.667000													10	68					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228547304	228547304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228547304G>A	ENST00000284548.11	+	81	18785	c.18711G>A	c.(18709-18711)gaG>gaA	p.E6237E	OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366709.4_Silent_p.E3356E|OBSCN_ENST00000570156.2_Intron			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6237					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCAGAGAAGAGACCATCACCA	0.647000													6	8					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142151420	142151420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142151420C>T	ENST00000519811.1	+	4	690	c.620C>T	c.(619-621)tCc>tTc	p.S207F	DENND3_ENST00000424248.1_Missense_Mutation_p.S127F|DENND3_ENST00000262585.2_Missense_Mutation_p.S127F|DENND3_ENST00000518347.1_Missense_Mutation_p.S207F			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	127	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GACTGCCTTTCCTGGTGAGCT	0.647000													7	109					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57761270	57761270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57761270C>T	ENST00000360716.3	+	16	2366	c.2145C>T	c.(2143-2145)tcC>tcT	p.S715S	CCDC135_ENST00000394337.4_Silent_p.S715S|CCDC135_ENST00000336825.8_Silent_p.S650S			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	715						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						TGACCATCTCCATCTATGACA	0.557000													46	93					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131922087	131922087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131922087C>T	ENST00000286355.5	-	6	3599	c.1507G>A	c.(1507-1509)Gat>Aat	p.D503N	ADCY8_ENST00000377928.3_Missense_Mutation_p.D503N	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	503					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ATGTCAACATCGTGTTTTGTC	0.478000										HNSCC(32;0.087)			17	91					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121384953	121384953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121384953G>A	ENST00000260197.7	+	8	1263	c.1134G>A	c.(1132-1134)gaG>gaA	p.E378E	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	378					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CAGAGGCAGAGGGGCTGAAGT	0.522000													6	92					0	0	1	0	0
RFPL1S	10740	broad.mit.edu	37	22	29833640	29833640	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29833640G>A	ENST00000461286.2	-	0	4736					NR_002727.2																						CCAATAAAACGCCCTCATGTG	0.522000													11	24					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348138	220348138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220348138G>A	ENST00000312358.7	+	30	6085	c.5953G>A	c.(5953-5955)Gag>Aag	p.E1985K	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1985					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCAGGACCAGGAGGCTCCCAG	0.711000													4	8					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31230642	31230642	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31230642G>A	ENST00000322122.3	+	4	803	c.519G>A	c.(517-519)ggG>ggA	p.G173G		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	173					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						GGGCCGTGGGGGAGCAGCTGG	0.667000													20	86					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70031747	70031747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70031747C>T	ENST00000355303.5	+	25	2945	c.2640C>T	c.(2638-2640)tcC>tcT	p.S880S	ANO1_ENST00000538023.1_Silent_p.S880S|ANO1_ENST00000531349.1_Silent_p.S589S|ANO1_ENST00000398543.2_Silent_p.S734S|ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000530676.1_Silent_p.S734S	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	880					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						ACGACATCTCCAAGGACTTCT	0.577000													16	80					0	0	1	0	0
KRT33B	3884	broad.mit.edu	37	17	39521143	39521143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39521143G>A	ENST00000251646.3	-	6	1034	c.985C>T	c.(985-987)Cgc>Tgc	p.R329C		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	329	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				AGGTCACTGCGGATCTCCGCC	0.627000													52	62					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120568516	120568516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120568516G>A	ENST00000300648.6	-	56	7617	c.7605C>T	c.(7603-7605)ctC>ctT	p.L2535L		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	2535					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGTCTCATGAGAAAGCCCA	0.607000													6	66					0	0	1	0	0
IGHV2-26	28455	broad.mit.edu	37	14	106757818	106757818	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106757818C>T	ENST00000390611.2	-	0	212																											CCAGGGCCTTCCCTGGGGGCT	0.537000													27	58					0	0	1	0	0
CNKSR3	154043	broad.mit.edu	37	6	154727673	154727673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:154727673G>A	ENST00000607772.1	-	13	2027	c.1483C>T	c.(1483-1485)Cgg>Tgg	p.R495W	CNKSR3_ENST00000433165.2_Missense_Mutation_p.R320W|CNKSR3_ENST00000479339.1_Missense_Mutation_p.R415W	NM_173515.2	NP_775786.2	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	495	DUF1170.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	15		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		TCCGCACCCCGGACCAGATGC	0.557000													42	38					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125081671	125081671	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125081671G>A	ENST00000522917.1	+	29	3995	c.3789G>A	c.(3787-3789)aaG>aaA	p.K1263K	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Silent_p.K1263K	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1263						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAATGCTCAAGAAGAAACCCA	0.468000													19	51					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113102448	113102448	+	Missense_Mutation	SNP	G	G	A	rs55757519		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113102448G>A	ENST00000316851.7	+	9	1141	c.1141G>A	c.(1141-1143)Gga>Aga	p.G381R	NCAM1_ENST00000401611.2_Missense_Mutation_p.G390R|NCAM1_ENST00000533760.1_Missense_Mutation_p.G263R|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	391	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane		p.G390*(2)|p.G381*(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		CACTGATGCCGGAGAGTACAT	0.592000													30	76					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27506194	27506194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27506194G>A	ENST00000356183.4	-	16	2683	c.2668C>T	c.(2668-2670)Ccc>Tcc	p.P890S	GTF3C1_ENST00000561623.1_Missense_Mutation_p.P890S	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	890						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGGATTGGGGGGATGTAGCGC	0.562000													7	39					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10747052	10747052	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10747052C>T	ENST00000586078.1	+	15	1396	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	SLC44A2_ENST00000407327.4_Silent_p.F427F|SLC44A2_ENST00000335757.5_Silent_p.F429F	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	429					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GTTGCCAGTTCGCCTTCTACG	0.602000													33	67					0	0	1	0	0
UGT1A7	54577	broad.mit.edu	37	2	234590739	234590739	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234590739G>A	ENST00000373426.3	+	1	156	c.156G>A	c.(154-156)ggG>ggA	p.G52G	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron	NM_019077.2	NP_061950.2														NS(1)|endometrium(6)|kidney(5)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|prostate(1)|skin(1)	33		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCCTCAGGGGGCATGAGGTGG	0.547000													10	174					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377997	113377997	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113377997G>A	ENST00000316407.4	-	7	2942	c.2532C>T	c.(2530-2532)ttC>ttT	p.F844F	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Silent_p.F844F	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	844					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						ACACAGCAGGGAAGCTTTCTA	0.473000													18	50					0	0	1	0	0
MYOG	4656	broad.mit.edu	37	1	203054621	203054621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203054621C>T	ENST00000241651.4	-	1	543	c.469G>A	c.(469-471)Ggg>Agg	p.G157R		NM_002479.4	NP_002470.2	P15173	MYOG_HUMAN	myogenin (myogenic factor 4)	157					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|urinary_tract(1)	12						CCACTTACCCCTGGCTGGGGC	0.697000													3	18					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86258507	86258507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:86258507G>A	ENST00000263857.6	-	30	4902	c.4524C>T	c.(4522-4524)atC>atT	p.I1508I	POLR1A_ENST00000409681.1_Intron			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1508					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						TGAACGGGTGGATCTCACGCA	0.677000													62	155					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107674717	107674717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107674717C>T	ENST00000388781.3	-	31	4837	c.4754G>A	c.(4753-4755)cGg>cAg	p.R1585Q	LAMB4_ENST00000483484.1_5'UTR|LAMB4_ENST00000205386.4_Missense_Mutation_p.R1585Q|LAMB4_ENST00000388780.3_Missense_Mutation_p.R1585Q	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1585	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						AGAGTTTGCCCGTCCTTGAGT	0.338000													55	132					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52232540	52232540	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:52232540G>A	ENST00000356297.4	-	23	4403	c.4303C>T	c.(4303-4305)Ccc>Tcc	p.P1435S	RP11-401H2.1_ENST00000521294.1_RNA|PXDNL_ENST00000543296.1_3'UTR	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1435	VWFC.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGGGACAGGGAGCCGGGGGA	0.483000													7	15					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26655803	26655803	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26655803C>T	ENST00000256737.3	+	19	2778	c.1926C>T	c.(1924-1926)ttC>ttT	p.F642F	ANO3_ENST00000537978.1_Silent_p.F626F|ANO3_ENST00000531568.1_Silent_p.F496F|ANO3_ENST00000525139.1_Silent_p.F626F	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	642						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						TGAAGATGTTCCTCTTCCAGT	0.393000													7	57					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3424448	3424448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3424448G>A	ENST00000356575.4	-	14	1926	c.1700C>T	c.(1699-1701)tCc>tTc	p.S567F	MEGF6_ENST00000294599.4_Missense_Mutation_p.S462F	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	567	EGF-like 10.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		ACAGCTGCAGGAGAAGCTGCA	0.602000													21	54					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51449363	51449363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:51449363G>A	ENST00000522124.1	+	11	1336	c.675G>A	c.(673-675)ttG>ttA	p.L225L	SNTG1_ENST00000517473.1_Silent_p.L225L|SNTG1_ENST00000518864.1_Silent_p.L225L|SNTG1_ENST00000276467.5_Silent_p.L225L	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	225					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GCACAGATTTGAGTCGGTGAG	0.453000													19	166					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192594	152192594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152192594C>T	ENST00000368801.2	-	3	1586	c.1511G>A	c.(1510-1512)gGt>gAt	p.G504D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	504					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGTCGTTCACCCCTAGATGA	0.552000													108	336					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108315553	108315553	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:108315553C>T	ENST00000520734.1	-	4	536	c.251G>A	c.(250-252)aGa>aAa	p.R84K	ANGPT1_ENST00000518386.1_Intron|ANGPT1_ENST00000520052.1_Missense_Mutation_p.R83K			Q15389	ANGP1_HUMAN	angiopoietin 1	284					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGCACAGTCTCTAAATGGTTT	0.313000													33	71					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7645572	7645572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:7645572G>A	ENST00000340209.4	+	5	802	c.505G>A	c.(505-507)Gaa>Aaa	p.E169K	RBFOX1_ENST00000552089.1_Missense_Mutation_p.E181K|RBFOX1_ENST00000550418.1_Missense_Mutation_p.E164K|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000436368.2_Missense_Mutation_p.E184K|RBFOX1_ENST00000547338.1_Missense_Mutation_p.E164K|RBFOX1_ENST00000553186.1_Missense_Mutation_p.E164K|RBFOX1_ENST00000311745.5_Missense_Mutation_p.E184K|RBFOX1_ENST00000355637.4_Missense_Mutation_p.E184K|RBFOX1_ENST00000422070.4_Missense_Mutation_p.E207K|RBFOX1_ENST00000547372.1_Missense_Mutation_p.E207K			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	164	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						CGTAACTTTCGAAAATAGTGC	0.453000													41	91					0	0	1	0	0
LIMS1	3987	broad.mit.edu	37	2	109276190	109276190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:109276190C>T	ENST00000393310.1	+	2	293	c.126C>T	c.(124-126)ttC>ttT	p.F42F	LIMS1_ENST00000410093.1_Silent_p.F46F|LIMS1_ENST00000393314.2_Silent_p.F104F|LIMS1_ENST00000544547.1_Silent_p.F54F|LIMS1_ENST00000338045.3_Silent_p.F42F|LIMS1_ENST00000542845.1_Silent_p.F104F|LIMS1_ENST00000332345.6_Silent_p.F42F|LIMS1_ENST00000462817.1_3'UTR|LIMS1_ENST00000409441.1_Silent_p.F79F	NM_001193488.1	NP_001180417.1	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	42	LIM zinc-binding 1.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	10						CTCAGTGCTTCCAGCAGTTCC	0.577000													19	98					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2967781	2967781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2967781C>T	ENST00000520002.1	-	44	7065	c.6510G>A	c.(6508-6510)ctG>ctA	p.L2170L	CSMD1_ENST00000542608.1_Silent_p.L2169L|CSMD1_ENST00000537824.1_Silent_p.L2169L|CSMD1_ENST00000602723.1_Silent_p.L2170L|CSMD1_ENST00000400186.3_Silent_p.L2170L|CSMD1_ENST00000602557.1_Silent_p.L2170L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2170	CUB 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCAGTCCTTCAGGATCGGAT	0.493000													4	29					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423159	56423159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56423159G>A	ENST00000588751.1	-	5	2048	c.2024C>T	c.(2023-2025)tCa>tTa	p.S675L	NLRP13_ENST00000342929.3_Missense_Mutation_p.S675L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	675							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TAGGCAAAATGAAGAAGCTTG	0.403000													16	171					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39425938	39425938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39425938C>T	ENST00000280481.7	+	11	7074	c.6858C>T	c.(6856-6858)tcC>tcT	p.S2286S		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2286	Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAAAGGTTTCCATTGTGAGAG	0.507000													22	62					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71103356	71103356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71103356G>A	ENST00000393567.2	-	14	1938	c.1788C>T	c.(1786-1788)ccC>ccT	p.P596P	HYDIN_ENST00000538248.1_Silent_p.P623P|HYDIN_ENST00000321489.5_Silent_p.P596P|HYDIN_ENST00000288168.10_Silent_p.P613P|HYDIN_ENST00000448691.1_Silent_p.P596P|HYDIN_ENST00000541601.1_Silent_p.P613P|HYDIN_ENST00000448089.2_Silent_p.P596P|HYDIN_ENST00000393550.2_Silent_p.P611P|HYDIN_ENST00000543639.1_5'UTR	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	596										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TGTAAGTCATGGGGATCAAAG	0.443000													11	38					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819408	43819408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43819408G>A	ENST00000382031.1	+	5	6482	c.6451G>A	c.(6451-6453)Gaa>Aaa	p.E2151K	MAP1A_ENST00000300231.5_Missense_Mutation_p.E1913K|MAP1A_ENST00000399453.1_Missense_Mutation_p.E1913K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1913						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCGCAAGGCTGAAGGGGAAAG	0.597000													21	71					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999049	143999049	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143999049G>A	ENST00000323110.2	-	1	210	c.208C>T	c.(208-210)Cag>Tag	p.Q70*		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	70					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TGGAAGGTCTGGTGCATCTCC	0.637000									Familial Hyperaldosteronism type I				29	62					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75869049	75869049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:75869049G>A	ENST00000377636.3	-	18	3603	c.3257C>T	c.(3256-3258)cCc>cTc	p.P1086L	TBC1D4_ENST00000377625.2_Missense_Mutation_p.P1023L|TBC1D4_ENST00000425511.1_Missense_Mutation_p.P250L|TBC1D4_ENST00000431480.2_Missense_Mutation_p.P1078L|TBC1D4_ENST00000478591.1_5'UTR	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1086	Rab-GAP TBC.					cytoplasm	Rab GTPase activator activity	p.P1086L(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GAGGAACCAGGGGGCAGCATA	0.393000													18	84					0	0	1	0	0
CTSS	1520	broad.mit.edu	37	1	150722495	150722495	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150722495G>A	ENST00000368985.3	-	6	1040	c.780C>T	c.(778-780)ttC>ttT	p.F260F	CTSS_ENST00000448301.2_Silent_p.F210F|CTSS_ENST00000480760.1_Intron	NM_001199739.1|NM_004079.4	NP_001186668.1|NP_004070.3	P25774	CATS_HUMAN	cathepsin S	260					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	15	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTGTAGAGGAAGAAAGAAG	0.393000													15	48					0	0	1	0	0
SIRT2	22933	broad.mit.edu	37	19	39384092	39384092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39384092G>A	ENST00000249396.7	-	4	489	c.188C>T	c.(187-189)aCc>aTc	p.T63I	SIRT2_ENST00000392081.2_Missense_Mutation_p.T26I|SIRT2_ENST00000358931.5_Missense_Mutation_p.T63I	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	63					cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			CCCTTCCAAGGTCAGCTCGTC	0.612000													13	28					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95372892	95372892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95372892C>T	ENST00000371447.3	+	1	548	c.410C>T	c.(409-411)cCa>cTa	p.P137L		NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	137	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				GTTGTGTTTCCATTGGACATT	0.527000													12	63					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41161948	41161948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41161948C>T	ENST00000263413.3	-	10	1569	c.1305G>A	c.(1303-1305)caG>caA	p.Q435Q	C6_ENST00000337836.5_Silent_p.Q435Q|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	435	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCTCTGCTCCCTGTATAAATG	0.398000													29	65					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159820456	159820456	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159820456C>T	ENST00000497452.1	-	0	517																											GTATGGAGTTCGAAAAGCAAT	0.408000													10	31					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219868840	219868840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219868840C>T	ENST00000341552.5	-	33	5472	c.5389G>A	c.(5389-5391)Gag>Aag	p.E1797K	CCDC108_ENST00000441968.1_Missense_Mutation_p.E1797K|AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000453220.1_Missense_Mutation_p.E1797K	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1797	Glu-rich.					integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		tcctccttctcctctatctcc	0.567000													11	100					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137727469	137727469	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137727469C>T	ENST00000314358.5	+	8	2348	c.2148C>T	c.(2146-2148)agC>agT	p.S716S	KDM3B_ENST00000394866.1_Silent_p.S372S|KDM3B_ENST00000542866.1_Intron	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	716	Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						GGGGCCCAAGCCTCTCTGCCA	0.572000													27	73					0	0	1	0	0
TMEM133	83935	broad.mit.edu	37	11	100863262	100863262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100863262C>T	ENST00000303130.2	+	1	452	c.223C>T	c.(223-225)Cct>Tct	p.P75S		NM_032021.2	NP_114410.1	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	75						integral to membrane				kidney(2)|large_intestine(1)|lung(1)|prostate(1)	5		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		CATTCTGTGTCCTGCCTGTCT	0.378000													41	186					0	0	1	0	0
ABCG2	9429	broad.mit.edu	37	4	89052351	89052351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89052351C>T	ENST00000237612.3	-	5	938	c.393G>A	c.(391-393)atG>atA	p.M131I	ABCG2_ENST00000515655.1_Missense_Mutation_p.M131I	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	131	ABC transporter.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	TCAGAGTGCCCATCACAACAT	0.378000													23	111					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107744	55107744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55107744G>A	ENST00000251372.3	+	7	1231	c.1049G>A	c.(1048-1050)gGg>gAg	p.G350E	LILRB1_ENST00000448689.1_Intron|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	350	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		CAGTCATGGGGGCCGTTCCAC	0.582000													41	86					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69265641	69265641	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:69265641C>T	ENST00000551568.1	-	4	414	c.354G>A	c.(352-354)cgG>cgA	p.R118R	CPM_ENST00000338356.3_Silent_p.R118R|CPM_ENST00000546373.1_Silent_p.R118R	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	118					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TGATGTGTATCCGGGTACTAT	0.463000													33	109					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1742181	1742181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1742181G>A	ENST00000381241.3	+	2	418	c.219G>A	c.(217-219)ctG>ctA	p.L73L	ASMT_ENST00000381233.3_Silent_p.L73L|ASMT_ENST00000381229.4_Silent_p.L73L	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	73					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGAAGCTGCTGAAAGTGGAGA	0.592000													10	37					0	0	1	0	0
TNIP1	10318	broad.mit.edu	37	5	150436378	150436378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150436378G>A	ENST00000389378.2	-	6	1164	c.576C>T	c.(574-576)aaC>aaT	p.N192N	TNIP1_ENST00000523338.1_Silent_p.N192N|TNIP1_ENST00000518977.1_Silent_p.N192N|TNIP1_ENST00000521591.1_Silent_p.N192N|TNIP1_ENST00000520931.1_Silent_p.N139N|TNIP1_ENST00000523200.1_Silent_p.N192N|TNIP1_ENST00000522226.1_Silent_p.N192N|TNIP1_ENST00000315050.7_Silent_p.N192N|TNIP1_ENST00000524280.1_Silent_p.N192N	NM_001252385.1|NM_001252393.1|NM_001258454.1|NM_006058.4	NP_001239314.1|NP_001239322.1|NP_001245383.1|NP_006049.3	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	192	Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(5)|ovary(2)|prostate(2)|skin(3)	23		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGCCAGTCGGTTGAACTCCA	0.667000													6	48					0	0	1	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074281	46074281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46074281G>A	ENST00000391618.1	-	1	295	c.251C>T	c.(250-252)tCc>tTc	p.S84F	TSPEAR_ENST00000323084.4_Intron	NM_198698.1	NP_941971.1	P60329	KR124_HUMAN	keratin associated protein 12-4	84	15 X 5 AA approximate repeats.					keratin filament				lung(4)|ovary(1)|prostate(1)	6						TGGGCAGAAGGAAGCCACACA	0.647000													21	43					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15713626	15713626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15713626C>T	ENST00000378076.3	-	8	1176	c.823G>A	c.(823-825)Gag>Aag	p.E275K		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	275					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CCAGTAAACTCCCCAGCAGCA	0.353000													17	50					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197703506	197703506	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:197703506G>A	ENST00000330198.4	+	5	491	c.469G>A	c.(469-471)Gat>Aat	p.D157N	LMLN_ENST00000482695.1_Missense_Mutation_p.D105N|LMLN_ENST00000420910.2_Missense_Mutation_p.D157N|LMLN_ENST00000332636.5_Missense_Mutation_p.D105N	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	157					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GAAGGAAAACGATCCTCACAG	0.438000													86	98					0	0	1	0	0
SLC17A1	6568	broad.mit.edu	37	6	25811976	25811976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25811976G>A	ENST00000244527.4	-	9	1035	c.920C>T	c.(919-921)cCc>cTc	p.P307L	SLC17A1_ENST00000468082.1_Missense_Mutation_p.P253L|SLC17A1_ENST00000427328.1_Missense_Mutation_p.P253L|SLC17A1_ENST00000476801.1_Missense_Mutation_p.P307L	NM_005074.3	NP_005065.2	Q14916	NPT1_HUMAN	solute carrier family 17 (organic anion transporter), member 1	307					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	36						AAACAAATAGGGAAGGGAAGA	0.433000													19	86					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45475275	45475275	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:45475275C>T	ENST00000361462.2	+	5	2892	c.2709C>T	c.(2707-2709)tcC>tcT	p.S903S	FAM179B_ENST00000382233.2_Silent_p.S903S|KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Silent_p.S903S			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	903							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						CGCCATCTTCCCGACGAGGTC	0.418000													42	146					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823648	38823648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38823648C>T	ENST00000303592.3	-	2	748	c.490G>A	c.(490-492)Gac>Aac	p.D164N		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	164		Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium (By similarity).			synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					ATGAAGGAGTCGATGACGCAG	0.627000													6	75					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119961497	119961497	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119961497G>A	ENST00000327554.2	+	11	1568		c.e11-1		RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60											endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TGTGTCCACAGCCGCACTAAT	0.567000													5	50					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8146431	8146431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8146431G>A	ENST00000315684.8	-	2	76	c.69C>T	c.(67-69)atC>atT	p.I23I	CTC1_ENST00000581671.1_Intron	NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	23					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						GGGTCTTTTGGATGAAGACCT	0.473000													15	22					0	0	1	0	0
EPPIN	57119	broad.mit.edu	37	20	44174367	44174367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44174367C>T	ENST00000354280.4	-	2	200	c.134G>A	c.(133-135)aGg>aAg	p.R45K	EPPIN_ENST00000336443.3_Missense_Mutation_p.R29K|EPPIN_ENST00000409554.1_Missense_Mutation_p.R45K|EPPIN-WFDC6_ENST00000504988.1_Missense_Mutation_p.R45K|EPPIN_ENST00000555685.1_Missense_Mutation_p.R45K	NM_020398.3	NP_065131.1			epididymal peptidase inhibitor																		ACACACATCCCTTTCTTGGAA	0.433000													71	133					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25260919	25260919	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25260919G>A	ENST00000354454.3	+	21	2254	c.1425G>A	c.(1423-1425)gaG>gaA	p.E475E	LRMP_ENST00000547044.1_Silent_p.E475E|LRMP_ENST00000548766.1_Silent_p.E475E	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	531					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					CACAGCAAGAGGACTCATGGA	0.483000													27	100					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52813459	52813459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52813459G>A	ENST00000273283.2	+	5	446	c.422G>A	c.(421-423)aGa>aAa	p.R141K	ITIH1_ENST00000542827.1_Missense_Mutation_p.R141K|ITIH1_ENST00000540715.1_5'UTR	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	141	VIT.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GCCTCGGGGAGAACTATGGAG	0.507000													18	31					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12774193	12774193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12774193G>A	ENST00000456935.2	-	6	887	c.847C>T	c.(847-849)Cgc>Tgc	p.R283C	MAN2B1_ENST00000221363.4_Missense_Mutation_p.R283C	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	283					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TCGGGGCTGCGAGGGTCCTCC	0.567000													35	73					0	0	1	0	0
LOC643201	643201	broad.mit.edu	37	5	175572124	175572124	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:175572124C>T	ENST00000515403.1	-	0	2993				RP11-826N14.4_ENST00000510029.1_lincRNA	NR_036494.1																						AGGTTTACTTCCTGAAGAATG	0.413000													5	27					0	0	1	0	0
OSGIN1	29948	broad.mit.edu	37	16	83999347	83999347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:83999347C>T	ENST00000343939.2	+	7	1801	c.1418C>T	c.(1417-1419)tCc>tTc	p.S473F	OSGIN1_ENST00000393306.1_Missense_Mutation_p.S390F|OSGIN1_ENST00000361711.3_Missense_Mutation_p.S390F			Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	473					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity			autonomic_ganglia(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12						TTTGGGGTCTCCCTGGTGCTG	0.647000													7	61					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39974767	39974767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39974767G>A	ENST00000321562.4	+	4	819	c.715G>A	c.(715-717)Gag>Aag	p.E239K		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	239	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GGCCTATGGCGAGAAAGGCTA	0.547000													4	14					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77465424	77465424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77465424C>T	ENST00000282849.5	-	3	681	c.263G>A	c.(262-264)cGa>cAa	p.R88Q	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	88					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CTGCGCCGATCGCTTTTTCCT	0.483000													48	278					0	0	1	0	0
RNF214	257160	broad.mit.edu	37	11	117152902	117152902	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117152902C>T	ENST00000530849.1	+	10	1173	c.1163C>T	c.(1162-1164)tCt>tTt	p.S388F	RNF214_ENST00000300650.4_Missense_Mutation_p.S543F|RNF214_ENST00000524917.1_Intron|RNF214_ENST00000531287.1_Missense_Mutation_p.S388F|RNF214_ENST00000531452.1_Missense_Mutation_p.S543F			Q8ND24	RN214_HUMAN	ring finger protein 214	543							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		GTTAAGGCTTCTGCTGAAACT	0.592000													28	201					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043180	56043180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56043180C>T	ENST00000313033.2	+	1	152	c.66C>T	c.(64-66)acC>acT	p.T22T		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					CTGAAGTCACCATGTTTATAT	0.299000													28	148					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940425	113940425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113940425C>T	ENST00000245796.6	+	2	587	c.392C>T	c.(391-393)tCa>tTa	p.S131L	PSD4_ENST00000441564.2_Missense_Mutation_p.S131L|PSD4_ENST00000465917.1_3'UTR	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	131					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AACACAGCATCACCAGGGTCA	0.622000													6	88					0	0	1	0	0
SLC36A1	206358	broad.mit.edu	37	5	150856304	150856304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150856304C>T	ENST00000243389.3	+	9	1199	c.976C>T	c.(976-978)Ctg>Ttg	p.L326L	SLC36A1_ENST00000520701.1_Silent_p.L326L|SLC36A1_ENST00000521925.1_Silent_p.L326L	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	326					cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	AACCCTCAACCTGCCCAACTG	0.498000													15	42					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108012092	108012092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108012092G>A	ENST00000280758.5	+	10	2917	c.2389G>A	c.(2389-2391)Gag>Aag	p.E797K	BTBD11_ENST00000357167.4_Missense_Mutation_p.E334K|BTBD11_ENST00000420571.2_Intron|BTBD11_ENST00000490090.2_Missense_Mutation_p.E797K	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	797						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GGCCCTGAGGGAGGCCATGTA	0.627000													11	34					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48266576	48266576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48266576G>A	ENST00000225964.5	-	40	3008	c.2890C>T	c.(2890-2892)Cct>Tct	p.P964S		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	964	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	CTCTGACCAGGCAGGCCGACC	0.617000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						5	30					0	0	1	0	0
OR1I1	126370	broad.mit.edu	37	19	15198326	15198326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15198326G>A	ENST00000209540.2	+	1	536	c.450G>A	c.(448-450)atG>atA	p.M150I		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						CATCATGGATGATCACCAACC	0.562000													15	43					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61769308	61769308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:61769308C>T	ENST00000423902.2	+	34	7948	c.7469C>T	c.(7468-7470)tCg>tTg	p.S2490L	CHD7_ENST00000524602.1_Intron|CHD7_ENST00000529472.1_3'UTR	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2490					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GCAGGCCTTTCGCGCACACCC	0.478000													33	165					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118865039	118865039	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:118865039G>A	ENST00000295622.1	+	1	43	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	1										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		GGCAGGAAATGGAAGAGCCTC	0.617000													5	24					0	0	1	0	0
IRX4	50805	broad.mit.edu	37	5	1879722	1879722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1879722C>T	ENST00000505790.1	-	5	1088	c.632G>A	c.(631-633)cGg>cAg	p.R211Q	IRX4_ENST00000513692.1_Missense_Mutation_p.R211Q|IRX4_ENST00000505938.1_5'UTR|IRX4_ENST00000231357.2_Missense_Mutation_p.R211Q	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	211					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		GCACTTGTTCCGCGGCGGCCA	0.662000													9	79					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292793	4292793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4292793C>T	ENST00000301272.2	-	5	697	c.652G>A	c.(652-654)Ggc>Agc	p.G218S	TMIGD2_ENST00000600114.1_Missense_Mutation_p.G98S|TMIGD2_ENST00000600349.1_Missense_Mutation_p.G46S|TMIGD2_ENST00000595645.1_Missense_Mutation_p.G214S	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	218						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGCTCTGGCCCCTCTGGTCC	0.642000													22	87					0	0	1	0	0
ADA	100	broad.mit.edu	37	20	43257798	43257798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43257798G>A	ENST00000372874.4	-	3	242	c.108C>T	c.(106-108)atC>atT	p.I36I	ADA_ENST00000537820.1_Silent_p.I36I	NM_000022.2	NP_000013.2	P00813	ADA_HUMAN	adenosine deaminase	36					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(2)|prostate(3)|skin(2)|urinary_tract(1)	18		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	CTGGGAGGGCGATCCCTCTCC	0.597000									Adenosine Deaminase Deficiency				21	42					0	0	1	0	0
ELF2	1998	broad.mit.edu	37	4	139988877	139988877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:139988877G>A	ENST00000394235.2	-	7	1040	c.538C>T	c.(538-540)Cct>Tct	p.P180S	ELF2_ENST00000265495.4_Missense_Mutation_p.P180S|ELF2_ENST00000510408.1_Missense_Mutation_p.P120S|ELF2_ENST00000379550.1_Missense_Mutation_p.P192S|ELF2_ENST00000358635.3_Missense_Mutation_p.P132S|ELF2_ENST00000379549.2_Intron	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	192					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					CCTAACTCAGGAGACCCATTG	0.363000													43	99					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307140	140307140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140307140C>T	ENST00000253807.2	+	1	663	c.663C>T	c.(661-663)atC>atT	p.I221I	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHAC1_ENST00000409700.3_Silent_p.I221I|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGTCACCATCATTGTGGTGG	0.582000													12	47					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1116178	1116178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1116178C>T	ENST00000379290.1	+	8	866	c.693C>T	c.(691-693)acC>acT	p.T231T	TTLL10_ENST00000379289.1_Silent_p.T231T|TTLL10_ENST00000379288.3_Silent_p.T158T			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	231	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGCTCAGCACCCTTCGGGGAC	0.692000													8	15					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903304	6903304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:6903304C>T	ENST00000486284.1	+	1	503	c.229C>T	c.(229-231)Cac>Tac	p.H77Y	GRM7_ENST00000357716.4_Missense_Mutation_p.H77Y|GRM7_ENST00000403881.1_Missense_Mutation_p.H77Y|GRM7_ENST00000402647.2_Missense_Mutation_p.H77Y|GRM7_ENST00000389336.4_Missense_Mutation_p.H77Y	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	77					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AAACGGGATCCACAGGCTGGA	0.647000													5	25					0	0	1	0	0
C3P1	388503	broad.mit.edu	37	19	10165979	10165979	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10165979G>A	ENST00000495140.1	+	0	1607																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						CACCTCCAAGGGGAACCCAGG	0.592000													16	61					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908728	103908728	+	Missense_Mutation	SNP	G	G	A	rs148474807	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103908728G>A	ENST00000302259.3	+	1	1421	c.1178G>A	c.(1177-1179)cGa>cAa	p.R393Q	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	393					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GATTCAGGACGAAAAGAGCAT	0.428000													9	52					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36348818	36348818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36348818C>T	ENST00000360631.3	-	17	2288	c.2077G>A	c.(2077-2079)Gag>Aag	p.E693K	DCLK1_ENST00000379893.1_Missense_Mutation_p.E386K|DCLK1_ENST00000255448.4_Silent_p.R717R			O15075	DCLK1_HUMAN	doublecortin-like kinase 1	693					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		ACCTGCCTCTCCTTATCAAGA	0.512000													3	10					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383741	108383741	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108383741C>T	ENST00000265843.4	-	6	2603	c.2493G>A	c.(2491-2493)caG>caA	p.Q831Q	EXPH5_ENST00000428840.1_Silent_p.Q755Q|EXPH5_ENST00000443411.1_Silent_p.Q643Q|EXPH5_ENST00000525344.1_Silent_p.Q824Q	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	831					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CAGTTAATTCCTGGTGACAAC	0.388000													54	138					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78071109	78071109	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78071109C>T	ENST00000397545.4	+	19	3114	c.3087C>T	c.(3085-3087)tcC>tcT	p.S1029S		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1029					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGAGCAGCTCCCTCCTAGAGA	0.562000													15	84					0	0	1	0	0
PBX4	80714	broad.mit.edu	37	19	19681534	19681534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19681534C>T	ENST00000251203.8	-	3	588	c.302G>A	c.(301-303)aGa>aAa	p.R101K		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	101							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						CGCTCCTCCTCTTCCTCTCTT	0.597000													26	70					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145303970	145303970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145303970C>T	ENST00000342960.5	+	9	1402	c.1367C>T	c.(1366-1368)tCa>tTa	p.S456L	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Missense_Mutation_p.S185L|NBPF10_ENST00000369339.2_Missense_Mutation_p.S185L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	456										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GTGCAGAAATCATCTGCCCCC	0.438000													56	353					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	371314	371314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:371314G>A	ENST00000342640.4	-	6	686	c.644C>T	c.(643-645)cCt>cTt	p.P215L	THEG_ENST00000346878.2_Missense_Mutation_p.P191L	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	215					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCCAGACAGGAGTCGTCCT	0.597000													69	138					0	0	1	0	0
CPD	1362	broad.mit.edu	37	17	28788251	28788251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:28788251C>T	ENST00000225719.4	+	18	3628	c.3552C>T	c.(3550-3552)tgC>tgT	p.C1184C	CPD_ENST00000584051.1_3'UTR|CPD_ENST00000543464.2_Silent_p.C937C	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	1184	Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						ACACAAGCTGCTGTTACTTTC	0.378000													34	48					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55002508	55002508	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:55002508C>T	ENST00000474759.1	+	28	2529	c.2481C>T	c.(2479-2481)ttC>ttT	p.F827F	CACNA2D3_ENST00000415676.2_Silent_p.F827F|CACNA2D3_ENST00000288197.5_Silent_p.F827F|CACNA2D3_ENST00000490478.1_Silent_p.F733F	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	827						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTGAATTTTTCCAAAGGAAGT	0.368000													4	14					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51261233	51261233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:51261233G>A	ENST00000395542.2	-	3	483	c.299C>T	c.(298-300)cCa>cTa	p.P100L	COBL_ENST00000395540.2_Missense_Mutation_p.P100L|COBL_ENST00000441453.1_Missense_Mutation_p.P100L|COBL_ENST00000265136.7_Missense_Mutation_p.P100L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	100										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					ATGGTGGGATGGATTCAGGTG	0.418000													7	83					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26482151	26482151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26482151G>A	ENST00000265944.5	+	32	4622	c.4456G>A	c.(4456-4458)Gag>Aag	p.E1486K	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1486					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TAAAGGAGAGGAGCCAAAAAT	0.353000													19	53					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123599975	123599975	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:123599975C>T	ENST00000340011.5	+	5	1839	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	SPAM1_ENST00000460182.1_Silent_p.F494F|SPAM1_ENST00000439500.1_Silent_p.F494F|SPAM1_ENST00000223028.7_Silent_p.F494F|SPAM1_ENST00000402183.2_Silent_p.F494F	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	494					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	CCACAATGTTCATTGTTAGTA	0.368000													30	76					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41062004	41062004	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41062004G>A	ENST00000352632.3	+	25	5185	c.5099G>A	c.(5098-5100)cGg>cAg	p.R1700Q	SPTBN4_ENST00000392023.1_Missense_Mutation_p.R376Q|SPTBN4_ENST00000392025.1_Missense_Mutation_p.R443Q|SPTBN4_ENST00000595535.1_Missense_Mutation_p.R1700Q|SPTBN4_ENST00000598249.1_Missense_Mutation_p.R1700Q|SPTBN4_ENST00000338932.3_Missense_Mutation_p.R1700Q			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1700					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CAGATCAGCCGGCGGCAGTCT	0.662000													4	23					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100175854	100175854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100175854G>A	ENST00000547776.2	-	5	690	c.691C>T	c.(691-693)Cat>Tat	p.H231Y	ANKS1B_ENST00000547010.1_Intron|ANKS1B_ENST00000329257.7_Missense_Mutation_p.H231Y	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	231						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GCTGCTTCATGAAGTGCACTC	0.373000													4	14					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88380164	88380164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:88380164G>A	ENST00000298699.2	-	10	1027	c.847C>T	c.(847-849)Cat>Tat	p.H283Y	C12orf50_ENST00000550553.1_Missense_Mutation_p.H244Y	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	283										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						CCTTTAAAATGAGGCTTCTTC	0.323000													18	43					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56246777	56246777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56246777C>T	ENST00000361673.3	-	4	1444	c.1231G>A	c.(1231-1233)Ggg>Agg	p.G411R		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	411							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTCCTCACCCCAACTTCTTGG	0.572000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	45					0	0	1	0	0
RHPN2	85415	broad.mit.edu	37	19	33517487	33517487	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33517487G>A	ENST00000254260.3	-	3	272	c.237C>T	c.(235-237)ttC>ttT	p.F79F	RHPN2_ENST00000400226.4_5'UTR	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	79					signal transduction	perinuclear region of cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					CTGAGTTGACGAAGCTCAGCT	0.562000													113	68					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20974824	20974824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20974824G>A	ENST00000261383.3	-	53	10381	c.10382C>T	c.(10381-10383)cCt>cTt	p.P3461L	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3461					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCAAGACCCAGGGAGTTGCTC	0.532000													9	53					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30686936	30686936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30686936C>T	ENST00000534862.1	+	13	1679	c.1316C>T	c.(1315-1317)cCa>cTa	p.P439L	HCK_ENST00000375862.2_Missense_Mutation_p.P458L|HCK_ENST00000520553.1_Missense_Mutation_p.P438L|HCK_ENST00000375852.2_Missense_Mutation_p.P459L|HCK_ENST00000518730.1_Missense_Mutation_p.P437L|HCK_ENST00000538448.1_Missense_Mutation_p.P438L	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	459	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ATCCCTTACCCAGGTAGGGAA	0.542000													37	112					0	0	1	0	0
DIRAS2	54769	broad.mit.edu	37	9	93375997	93375997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:93375997G>A	ENST00000375765.3	-	2	501	c.113C>T	c.(112-114)cCg>cTg	p.P38L		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	38					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity	p.P38Q(1)		kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						TTCCACCGTCGGGATGTAGCT	0.577000													28	161					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52306893	52306893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52306893G>A	ENST00000550683.1	+	2	215	c.114G>A	c.(112-114)gtG>gtA	p.V38V	ACVRL1_ENST00000388922.4_Silent_p.V24V|ACVRL1_ENST00000419526.2_Intron	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	24					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GAGACCCTGTGAAGCCGTCTC	0.657000													7	9					0	0	1	0	0
SLC25A18	83733	broad.mit.edu	37	22	18070755	18070755	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18070755G>A	ENST00000327451.5	+	9	1178	c.640G>A	c.(640-642)Gag>Aag	p.E214K	SLC25A18_ENST00000399813.1_Missense_Mutation_p.E214K|AC004019.13_ENST00000443935.1_RNA	NM_031481.1	NP_113669.1	Q9H1K4	GHC2_HUMAN	solute carrier family 25 (glutamate carrier), member 18	214						integral to membrane|mitochondrial inner membrane	binding|symporter activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	18				Lung(27;0.124)	L-Glutamic Acid(DB00142)	GGGGTTCAACGAGCTCGCCGG	0.532000													47	101					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004526	41004526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41004526G>A	ENST00000399564.4	-	37	4566	c.4116C>T	c.(4114-4116)atC>atT	p.I1372I	MROH2B_ENST00000506092.2_Silent_p.I927I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GCAGCTCCAGGATTTTTTTTA	0.438000													36	114					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73063793	73063793	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73063793G>A	ENST00000429829.1	-	0	8795					NR_001564.2																						CACCAGAAGGGGCCTTGGAGG	0.398000													8	8					0	0	1	0	0
C1orf158	93190	broad.mit.edu	37	1	12819318	12819318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12819318C>T	ENST00000288048.5	+	3	517	c.301C>T	c.(301-303)Cat>Tat	p.H101Y	C1orf158_ENST00000376210.3_Missense_Mutation_p.H63Y	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	101										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CTATGACGACCATTACAACCG	0.567000													74	166					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7976167	7976167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7976167G>A	ENST00000319144.4	-	15	2288	c.2028C>T	c.(2026-2028)atC>atT	p.I676I		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	676	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						TGCGCTGGCGGATGTCGTGTG	0.602000										Multiple Myeloma(8;0.094)			6	50					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306867	54306867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54306867G>A	ENST00000545554.1	+	1	1767	c.1767G>A	c.(1765-1767)agG>agA	p.R589R	UNC13C_ENST00000537900.1_Silent_p.R589R|UNC13C_ENST00000260323.11_Silent_p.R589R			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	589					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TATGGCAGAGGAAACAGGAAG	0.463000													26	51					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211735	38211735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38211735G>A	ENST00000379705.3	-	11	3096	c.2239C>T	c.(2239-2241)Cgc>Tgc	p.R747C	TRPC4_ENST00000358477.2_Missense_Mutation_p.R747C|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000379673.2_Missense_Mutation_p.R682C|TRPC4_ENST00000338947.5_Missense_Mutation_p.R574C|TRPC4_ENST00000355779.2_Intron|TRPC4_ENST00000379679.1_Missense_Mutation_p.R574C|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379681.3_Missense_Mutation_p.R752C			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	747	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACTTCAAAGCGGAAACTAGAA	0.363000													20	64					0	0	1	0	0
AKR7L	246181	broad.mit.edu	37	1	19593689	19593689	+	RNA	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19593689T>C	ENST00000420396.2	-	0	903				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						TTTTTCCAAATACTTCCATCC	0.418000													9	14					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713148	70713148	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70713148C>T	ENST00000530196.1	-	0	1370					NR_003951.1																						CCACACCATTCCCACAGCGCT	0.468000													31	88					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42874365	42874365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42874365C>T	ENST00000334370.4	+	38	7293	c.6658C>T	c.(6658-6660)Ccg>Tcg	p.P2220S	MEGF8_ENST00000251268.6_Missense_Mutation_p.P2287S|MEGF8_ENST00000378073.4_5'UTR	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2287						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GCAGTGCCTCCCGCTGTTTGT	0.612000													17	49					0	0	1	0	0
EXOC3L2	90332	broad.mit.edu	37	19	45728116	45728116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45728116C>T	ENST00000413988.1	-	6	500	c.460G>A	c.(460-462)Gaa>Aaa	p.E154K	EXOC3L2_ENST00000252482.3_Missense_Mutation_p.E154K	NM_138568.3	NP_612635.3	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	154										endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		GCAGATGCTTCCCGGGCCGGC	0.652000													7	17					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104176568	104176568	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104176568G>T	ENST00000020673.5	-	2	754	c.228C>A	c.(226-228)ccC>ccA	p.P76P	PSD_ENST00000492902.2_5'UTR|PSD_ENST00000406432.1_Silent_p.P76P	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	76	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GAGCAACACGGGGTGAGGGGG	0.672000													31	71					4.02929e-09	4.04455e-09	1	1	0
DNAH7	56171	broad.mit.edu	37	2	196651856	196651856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196651856G>A	ENST00000312428.6	-	58	10856	c.10756C>T	c.(10756-10758)Cat>Tat	p.H3586Y	DNAH7_ENST00000409063.1_Missense_Mutation_p.H69Y	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3586	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACCAAAGCATGAAAGAAACAC	0.388000													21	92					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6862869	6862869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6862869G>A	ENST00000307659.5	+	7	1215	c.760G>A	c.(760-762)Gag>Aag	p.E254K	KIAA0232_ENST00000425103.1_Missense_Mutation_p.E254K	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	254							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						AAGCAAAAACGAGAAGGAAAA	0.428000													12	72					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181701992	181701992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181701992C>T	ENST00000526775.1	+	19	2878	c.2713C>T	c.(2713-2715)Cgc>Tgc	p.R905C	CACNA1E_ENST00000367567.4_Missense_Mutation_p.R531C|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R856C|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R924C|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R905C|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R924C|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R875C	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	924					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CAGCCGGCATCGCCGCGTCAG	0.647000													34	116					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27517296	27517296	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27517296G>A	ENST00000356183.4	-	10	1709	c.1694C>T	c.(1693-1695)tCc>tTc	p.S565F	GTF3C1_ENST00000561623.1_Missense_Mutation_p.S565F	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	565						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGAGACAAAGGACACGTTGGG	0.587000													48	82					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6501056	6501056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6501056G>A	ENST00000377828.1	+	5	1089	c.921G>A	c.(919-921)acG>acA	p.T307T		NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	307					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		ACGGGTACACGGCCGCCGACC	0.697000													4	19					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129276034	129276034	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129276034C>T	ENST00000324093.4	-	34	5656	c.5478G>A	c.(5476-5478)aaG>aaA	p.K1826K	PLXND1_ENST00000504689.1_5'UTR|PLXND1_ENST00000393239.1_3'UTR	NM_015103.2	NP_055918.2	Q9Y4D7	PLXD1_HUMAN	plexin D1	1826					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CAGGAATCTCCTTGGCGTAGA	0.557000													25	74					0	0	1	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64698931	64698931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64698931C>T	ENST00000164133.2	+	9	1537	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_006244.3	NP_006235.1	Q15173	2A5B_HUMAN	protein phosphatase 2, regulatory subunit B', beta	305					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)	21						TGGTGCAGTTCCTGGAGAAGG	0.602000													14	26					0	0	1	0	0
RAB6C	84084	broad.mit.edu	37	2	130738443	130738443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130738443C>T	ENST00000410061.2	+	1	1209	c.755C>T	c.(754-756)tCg>tTg	p.S252L		NM_032144.2	NP_115520.2	Q9H0N0	RAB6C_HUMAN	RAB6C, member RAS oncogene family	252					protein transport|response to drug|small GTPase mediated signal transduction		GTP binding|GTPase activity			large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	5	Colorectal(110;0.1)					CTGCCTGTCTCGTGGAGGTGA	0.373000													31	84					0	0	1	0	0
RSPH4A	345895	broad.mit.edu	37	6	116938431	116938431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116938431G>A	ENST00000229554.5	+	1	782	c.645G>A	c.(643-645)aaG>aaA	p.K215K	RSPH4A_ENST00000368580.4_Silent_p.K215K|RSPH4A_ENST00000368581.4_Silent_p.K215K	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	215					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						AGAATGCTAAGGCTTACCTGC	0.483000									Kartagener syndrome				20	82					0	0	1	0	0
RASL10B	91608	broad.mit.edu	37	17	34068188	34068188	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34068188C>T	ENST00000268864.3	+	4	853	c.476C>T	c.(475-477)tCg>tTg	p.S159L		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	159	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTGGAATGCTCGGCCAAGTAC	0.647000													17	26					0	0	1	0	0
HTR3E	285242	broad.mit.edu	37	3	183822058	183822058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183822058C>T	ENST00000415389.2	+	4	834	c.368C>T	c.(367-369)cCa>cTa	p.P123L	HTR3E_ENST00000436361.2_Missense_Mutation_p.P123L|HTR3E_ENST00000440596.2_Missense_Mutation_p.P123L|HTR3E-AS1_ENST00000431427.1_RNA|HTR3E_ENST00000425359.2_Missense_Mutation_p.P108L|HTR3E_ENST00000335304.2_Missense_Mutation_p.P138L	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	123						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CTGTGGCTCCCAGACATTTTC	0.517000													8	20					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23810624	23810624	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23810624G>A	ENST00000354639.3	+	14	2109	c.1644_splice	c.e14-1	p.D549_splice	STK31_ENST00000433467.2_Splice_Site_p.D572_splice|STK31_ENST00000355870.3_Splice_Site_p.D572_splice|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Splice_Site_p.D549_splice	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	572							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTTCATTTAGGATCAAGGTGA	0.338000													41	88					0	0	1	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6890533	6890533	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6890533C>T	ENST00000419673.2	+	13	1579	c.1362C>T	c.(1360-1362)ctC>ctT	p.L454L	ARHGAP28_ENST00000531294.1_Silent_p.L449L|ARHGAP28_ENST00000418986.1_Silent_p.L454L|ARHGAP28_ENST00000262227.3_Silent_p.L561L|ARHGAP28_ENST00000314319.3_Silent_p.L454L|ARHGAP28_ENST00000383472.4_Silent_p.L613L|ARHGAP28_ENST00000532996.1_Silent_p.L436L|ARHGAP28_ENST00000400091.2_Silent_p.L613L	NM_001010000.2	NP_001010000.1	B4DXL2	B4DXL2_HUMAN	Rho GTPase activating protein 28	436					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				GGAAGACCCTCGAGCGGGAGG	0.473000													9	26					0	0	1	0	0
WFDC3	140686	broad.mit.edu	37	20	44416581	44416581	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44416581G>A	ENST00000243938.4	-	4	335	c.252C>T	c.(250-252)tcC>tcT	p.S84S	WFDC3_ENST00000372632.2_Intron|WFDC3_ENST00000481847.1_5'UTR|WFDC3_ENST00000372630.2_Intron	NM_080614.1	NP_542181.1	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3	84	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity	p.S84>?(1)		endometrium(1)|large_intestine(3)|prostate(1)	5		Myeloproliferative disorder(115;0.0122)				TTTTCAAACAGGATTGTTTCC	0.463000													26	64					0	0	1	0	0
OR12D3	81797	broad.mit.edu	37	6	29342696	29342696	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29342696G>A	ENST00000396806.3	-	1	372	c.369C>T	c.(367-369)gcC>gcT	p.A123A	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						GATTGCAGATGGCAACAAAAC	0.488000													10	56					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89653510	89653510	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89653510C>T	ENST00000268720.5	+	11	1282	c.1152_splice	c.e11+1	p.T384_splice	CPNE7_ENST00000319518.8_Splice_Site_p.T309_splice	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	384	VWFA.				lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		TCCACTTCACCGTGAGTCCAT	0.721000													4	2					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50903491	50903491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50903491G>A	ENST00000380817.2	-	12	1454	c.1271C>T	c.(1270-1272)gCc>gTc	p.A424V	SBF1_ENST00000348911.6_Missense_Mutation_p.A425V|SBF1_ENST00000390679.3_Missense_Mutation_p.A424V	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	424	dDENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GCCAGCAAAGGCCATGCCCTC	0.647000													15	27					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100210086	100210086	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:100210086G>A	ENST00000317233.4	-	14	2272	c.2037C>T	c.(2035-2037)tcC>tcT	p.S679S	AFF3_ENST00000409236.1_Silent_p.S679S|AFF3_ENST00000409579.1_Silent_p.S704S|AFF3_ENST00000356421.2_Silent_p.S704S	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	679	Poly-Ser.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.S704>?(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						ACTCCAGGTCGGAGTCCGAGG	0.612000													32	109					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59899274	59899274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:59899274G>A	ENST00000265036.5	-	9	1253	c.1186C>T	c.(1186-1188)Cct>Tct	p.P396S	DEPDC1B_ENST00000453022.2_Missense_Mutation_p.P396S|DEPDC1B_ENST00000545085.1_Missense_Mutation_p.P369S	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	396					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity	p.P396S(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				AAGGCCAAAGGGACTTTCAGA	0.418000													26	67					0	0	1	0	0
GYPA	2993	broad.mit.edu	37	4	145038021	145038021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:145038021G>A	ENST00000360771.4	-	5	458	c.343C>T	c.(343-345)Cgc>Tgc	p.R115C	GYPA_ENST00000504786.1_Missense_Mutation_p.R83C|GYPA_ENST00000503627.1_Missense_Mutation_p.R70C|GYPB_ENST00000283126.7_Intron|GYPA_ENST00000324022.10_Missense_Mutation_p.R82C|GYPA_ENST00000535709.1_Missense_Mutation_p.R89C|GYPA_ENST00000512789.1_Missense_Mutation_p.R50C|GYPA_ENST00000512064.1_Missense_Mutation_p.R102C|RP11-673E1.4_ENST00000506982.1_RNA	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	115					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					ATCAGTCGGCGAATACCGTAA	0.368000													41	97					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15580660	15580660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15580660G>A	ENST00000292609.4	-	4	1553	c.1424C>T	c.(1423-1425)tCc>tTc	p.S475F	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.S475F			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	475					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GAAGCCCCGGGAGTTGTGGCC	0.706000													4	11					0	0	1	0	0
SWI5	375757	broad.mit.edu	37	9	131038524	131038524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131038524C>T	ENST00000320188.4	+	1	100	c.100C>T	c.(100-102)Cct>Tct	p.P34S		NM_001040011.1	NP_001035100.1	Q1ZZU3	SWI5_HUMAN	SWI5 recombination repair homolog (yeast)	34					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding										GGCCGGCTTTCCTTGGGTGCG	0.682000													12	15					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4968065	4968065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:4968065G>A	ENST00000333703.4	+	5	2926	c.2413G>A	c.(2413-2415)Gaa>Aaa	p.E805K	PCDH11Y_ENST00000215473.6_Missense_Mutation_p.E816K|PCDH11Y_ENST00000362095.5_Missense_Mutation_p.E816K	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	816	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						ACTGATTAATGAACTGGTGCG	0.438000													21	85					0	0	1	0	0
UVRAG	7405	broad.mit.edu	37	11	75852018	75852018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75852018C>T	ENST00000356136.3	+	15	1902	c.1661C>T	c.(1660-1662)tCc>tTc	p.S554F	UVRAG_ENST00000528420.1_Missense_Mutation_p.S453F|UVRAG_ENST00000531818.1_Missense_Mutation_p.S182F|UVRAG_ENST00000533454.1_Missense_Mutation_p.S182F|UVRAG_ENST00000539288.1_Missense_Mutation_p.S182F|UVRAG_ENST00000538870.1_Missense_Mutation_p.S110F|UVRAG_ENST00000532130.1_Missense_Mutation_p.S182F	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	554					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						TTGGATACCTCCTTGGACTTC	0.502000													16	53					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96702033	96702033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96702033G>A	ENST00000260682.6	+	3	428	c.416G>A	c.(415-417)aGg>aAg	p.R139K	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	139					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	ATGGGGAAGAGGAGCATTGAG	0.498000													50	105					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55955503	55955503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55955503C>T	ENST00000373965.2	-	11	1639	c.1245G>A	c.(1243-1245)tcG>tcA	p.S415S	PCDH15_ENST00000395445.1_Silent_p.S415S|PCDH15_ENST00000373957.3_Silent_p.S393S|PCDH15_ENST00000395446.1_Silent_p.S415S|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Silent_p.S420S|PCDH15_ENST00000395433.1_Silent_p.S393S|PCDH15_ENST00000395430.1_Silent_p.S415S|PCDH15_ENST00000373955.1_Silent_p.S415S|PCDH15_ENST00000395440.1_Silent_p.S415S|PCDH15_ENST00000361849.3_Silent_p.S415S|PCDH15_ENST00000395438.1_Silent_p.S415S|PCDH15_ENST00000409834.1_Silent_p.S19S|PCDH15_ENST00000437009.1_Silent_p.S415S|PCDH15_ENST00000320301.6_Silent_p.S415S|PCDH15_ENST00000395432.2_Silent_p.S378S	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	415	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGAGACTGTCCGAAATGGTTG	0.368000										HNSCC(58;0.16)			31	77					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29498068	29498068	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29498068C>T	ENST00000389048.3	-	11	2844	c.1938G>A	c.(1936-1938)caG>caA	p.Q646Q	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	646					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTGCTGTATTCTGCAGGATCT	0.488000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				20	64					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466993	56466993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56466993C>T	ENST00000291971.3	+	3	1640	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F	NLRP8_ENST00000590542.1_Silent_p.F523F	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	523	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTCTCTGTTTCCCACAAAGAC	0.443000													61	176					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57587458	57587458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57587458C>T	ENST00000243077.3	+	47	8260	c.7794C>T	c.(7792-7794)atC>atT	p.I2598I		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2598	LDL-receptor class A 12.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTGACGAGATCCCTTGCAACA	0.612000													10	52					0	0	1	0	0
IL15RA	3601	broad.mit.edu	37	10	6008124	6008124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6008124G>A	ENST00000525219.2	-	2	453	c.159C>T	c.(157-159)ccC>ccT	p.P53P	IL15RA_ENST00000397250.2_Intron|IL15RA_ENST00000528354.1_Silent_p.P89P|IL15RA_ENST00000397251.3_Intron|IL15RA_ENST00000397248.2_Silent_p.P53P|IL15RA_ENST00000379971.1_Intron|IL15RA_ENST00000379977.3_Silent_p.P89P|IL15RA_ENST00000530685.1_Silent_p.P89P|IL15RA_ENST00000397255.3_Silent_p.P89P|IL15RA_ENST00000534292.1_5'UTR	NM_001243539.1	NP_001230468.1	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha	89	Sushi.				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5						ATTTGAGACTGGGGGTTGTCC	0.572000													8	36					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151337180	151337180	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151337180C>T	ENST00000435071.1	-	12	1528	c.1064_splice	c.e12-1	p.E356_splice	SELENBP1_ENST00000368868.5_Splice_Site_p.E420_splice|SELENBP1_ENST00000426705.2_Splice_Site_p.E462_splice|SELENBP1_ENST00000447402.3_Splice_Site_p.E358_splice			Q13228	SBP1_HUMAN	selenium binding protein 1	420					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACAGAGCCTTCCCTGGTGGAA	0.557000													16	156					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77389848	77389848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77389848C>T	ENST00000282849.5	-	9	1867	c.1449G>A	c.(1447-1449)aaG>aaA	p.K483K		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	483	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGAGGAATTTCTTGAGATACT	0.478000													10	105					0	0	1	0	0
SPNS2	124976	broad.mit.edu	37	17	4437103	4437103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4437103G>A	ENST00000329078.3	+	9	1509	c.1299G>A	c.(1297-1299)gaG>gaA	p.E433E		NM_001124758.1	NP_001118230.1	Q8IVW8	SPNS2_HUMAN	spinster homolog 2 (Drosophila)	433					lipid transport|transmembrane transport	integral to membrane				large_intestine(3)|lung(1)|prostate(1)|skin(1)	6						TCGTCGGGGAGACGCTGCTGT	0.592000													8	46					0	0	1	0	0
TMEM180	79847	broad.mit.edu	37	10	104235581	104235581	+	Missense_Mutation	SNP	A	A	C	rs144994591		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104235581A>C	ENST00000238936.4	+	10	1631	c.1394A>C	c.(1393-1395)cAg>cCg	p.Q465P	TMEM180_ENST00000366277.2_Missense_Mutation_p.Q194P	NM_024789.3	NP_079065.2	Q14CX5	TM180_HUMAN	transmembrane protein 180	465						integral to membrane				breast(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|skin(1)	13		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ACGCTCCGCCAGGGCTGCTTC	0.652000													14	37					0	0	1	0	0
HCN3	57657	broad.mit.edu	37	1	155253804	155253804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155253804C>T	ENST00000368358.3	+	3	756	c.748C>T	c.(748-750)Cgc>Tgc	p.R250C	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	250						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGCTGTGGTTCGCATCTTCAA	0.572000													31	88					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7064557	7064557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7064557G>A	ENST00000299481.4	+	4	1646	c.1300G>A	c.(1300-1302)Gga>Aga	p.G434R		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	434	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CGCTGCCAAAGGAATATGGAC	0.428000													57	137					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3440797	3440797	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3440797G>A	ENST00000356575.4	-	5	721	c.495C>T	c.(493-495)tgC>tgT	p.C165C	MEGF6_ENST00000294599.4_Silent_p.C60C	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	165	EGF-like 2; calcium-binding (Potential).					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TGTGGGTTCGGCATTCGTCCA	0.647000													18	49					0	0	1	0	0
GOT2	2806	broad.mit.edu	37	16	58750625	58750625	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58750625G>A	ENST00000245206.5	-	7	923	c.795C>T	c.(793-795)atC>atT	p.I265I	GOT2_ENST00000564400.1_Intron|GOT2_ENST00000434819.2_Silent_p.I222I	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	265					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TGCCCTGTTCGATGAAGTGGC	0.488000													11	39					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168212924	168212924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168212924G>A	ENST00000519560.1	-	12	1558	c.1139C>T	c.(1138-1140)tCc>tTc	p.S380F	SLIT3_ENST00000332966.8_Missense_Mutation_p.S380F|SLIT3_ENST00000404867.3_Missense_Mutation_p.S380F	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	380					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGCTGTAGGGACACCAGCCC	0.502000													20	52					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48220034	48220034	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48220034C>T	ENST00000263277.3	+	2	416	c.165C>T	c.(163-165)ttC>ttT	p.F55F	EHD2_ENST00000538399.1_Intron|CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	55					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		ACGCAGACTTCGACGGCAAGC	0.677000													13	25					0	0	1	0	0
TMEM57	55219	broad.mit.edu	37	1	25824819	25824819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:25824819C>T	ENST00000374343.4	+	11	2036	c.1857C>T	c.(1855-1857)gcC>gcT	p.A619A	TMEM57_ENST00000399763.3_Silent_p.A261A|TMEM57_ENST00000399766.3_Silent_p.A392A	NM_018202.4	NP_060672.2	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	619						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part		p.A619A(1)		breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		AAGTCATGGCCGTCATGCCCA	0.502000													38	93					0	0	1	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209950791	209950791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209950791G>A	ENST00000367024.1	+	12	1664	c.1148G>A	c.(1147-1149)gGg>gAg	p.G383E	TRAF3IP3_ENST00000477431.1_Missense_Mutation_p.G119E|TRAF3IP3_ENST00000400959.3_Missense_Mutation_p.G363E|TRAF3IP3_ENST00000367023.1_Missense_Mutation_p.G119E|TRAF3IP3_ENST00000367025.3_Missense_Mutation_p.G383E|TRAF3IP3_ENST00000367026.3_Missense_Mutation_p.G363E|TRAF3IP3_ENST00000010338.4_Missense_Mutation_p.G363E			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	383						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		TGCCTGCAAGGGGACAGAGAC	0.522000													14	48					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156814893	156814893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156814893G>A	ENST00000368195.3	-	12	2808	c.2412C>T	c.(2410-2412)ttC>ttT	p.F804F	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	804					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCGCAAAGACGAAGGTGGCGG	0.632000													3	1					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86416200	86416200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86416200G>A	ENST00000361669.2	+	3	2191	c.1092G>A	c.(1090-1092)caG>caA	p.Q364Q	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Silent_p.Q236Q|GRM3_ENST00000394720.2_Silent_p.Q362Q|GRM3_ENST00000439827.1_Silent_p.Q364Q	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	364					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCAGCCTCCAGAACAAACGCA	0.567000													20	43					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30701523	30701523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30701523C>T	ENST00000256246.2	-	1	5085	c.5011G>A	c.(5011-5013)Gac>Aac	p.D1671N		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1671										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGGTTTTGGTCTACCAACAGT	0.338000													23	80					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819464	159819464	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159819464C>T	ENST00000497452.1	-	0	517																											AGAGAGAGGACTCTGGAGATG	0.463000													81	204					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75929447	75929447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:75929447G>A	ENST00000321027.3	-	3	630	c.497C>T	c.(496-498)tCc>tTc	p.S166F	GCFC2_ENST00000409857.3_Missense_Mutation_p.S166F|GCFC2_ENST00000470503.1_Missense_Mutation_p.S166F|GCFC2_ENST00000541687.1_Missense_Mutation_p.S166F	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	166					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										ACCAGAGATGGAGGAGGTATG	0.448000													57	121					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141457966	141457966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141457966G>A	ENST00000389484.3	-	41	7623	c.6652C>T	c.(6652-6654)Cca>Tca	p.P2218S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2218					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAATAACGTGGATTCTCATAT	0.333000										TSP Lung(27;0.18)			20	131					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33590868	33590868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33590868C>T	ENST00000380099.3	+	1	298	c.290C>T	c.(289-291)cCc>cTc	p.P97L	KL_ENST00000426690.2_Intron|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	97	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACCCACCACCCCCTGGCACCC	0.721000													5	17					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767873	105767873	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:105767873G>A	ENST00000374798.3	+	5	1030	c.960G>A	c.(958-960)aaG>aaA	p.K320K	CYLC2_ENST00000487798.1_Silent_p.K320K	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	320	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				aggatgcaaagaaaaatgcta	0.398000													7	21					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141059162	141059162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141059162G>A	ENST00000239440.4	-	4	713	c.648C>T	c.(646-648)gcC>gcT	p.A216A	ARAP3_ENST00000508305.1_Silent_p.A138A	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	216					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TTCTGTCGGGGGCTCCTGGAG	0.572000													15	61					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16306646	16306646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:16306646C>T	ENST00000244769.4	-	9	3298	c.2362G>A	c.(2362-2364)Gaa>Aaa	p.E788K	ATXN1_ENST00000436367.1_Missense_Mutation_p.E788K	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	788	Interaction with USP7.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				AAAGGTGGTTCGTCTTCTGAC	0.547000													35	79					0	0	1	0	0
CBL	867	broad.mit.edu	37	11	119156009	119156009	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119156009C>T	ENST00000264033.4	+	11	2050	c.1674C>T	c.(1672-1674)tcC>tcT	p.S558S		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	558	Pro-rich.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		GAGCAGAATCCCGACCTCAAA	0.577000			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies		OREG0021401	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	72					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108051462	108051462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108051462C>T	ENST00000280758.5	+	17	3810	c.3282C>T	c.(3280-3282)atC>atT	p.I1094I	BTBD11_ENST00000357167.4_Silent_p.I631I|BTBD11_ENST00000420571.2_Silent_p.I975I|BTBD11_ENST00000494235.2_Silent_p.I173I	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	1094						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TTCAGTCCATCCACTTGTCGT	0.507000													24	56					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40030920	40030920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40030920G>A	ENST00000372857.3	-	8	1895	c.1103C>T	c.(1102-1104)gCc>gTc	p.A368V	PABPC4_ENST00000372858.3_Missense_Mutation_p.A368V|RP11-69E11.8_ENST00000415255.1_RNA|PABPC4_ENST00000372856.3_Missense_Mutation_p.A368V|PABPC4_ENST00000372862.3_Missense_Mutation_p.A368V	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	368	RRM 4.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTTCCTCTGGGCCAGGGCAAC	0.498000													5	50					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110864522	110864522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110864522G>A	ENST00000265171.5	+	3	885	c.440G>A	c.(439-441)gGa>gAa	p.G147E	EGF_ENST00000502723.1_3'UTR|EGF_ENST00000509793.1_Missense_Mutation_p.G147E|EGF_ENST00000503392.1_Missense_Mutation_p.G147E	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	147					angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GATATGAAAGGAAATAATTCC	0.308000													35	76					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159170685	159170685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159170685G>A	ENST00000368125.4	+	9	1327	c.1170G>A	c.(1168-1170)ggG>ggA	p.G390G	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000368124.4_Silent_p.G424G|CADM3_ENST00000497636.1_3'UTR	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	390					adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					AGTCAGGAGGGGACGACAAGA	0.612000													17	89					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102212	168102212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168102212G>A	ENST00000409195.1	+	9	4399	c.4310G>A	c.(4309-4311)cGa>cAa	p.R1437Q	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R1437Q|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.R1215Q	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1262					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AACTATATACGAACAGTAAGT	0.338000													13	53					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584330	30584330	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30584330C>T	ENST00000217299.3	+	3	984	c.810C>T	c.(808-810)ctC>ctT	p.L270L		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	270						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CCGCCTCCCTCGTGTCTCTGG	0.711000													7	16					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176813028	176813028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176813028C>T	ENST00000324417.5	+	3	241	c.150C>T	c.(148-150)ccC>ccT	p.P50P	SLC34A1_ENST00000512593.1_Silent_p.P50P	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	50					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATGCCTTCCCCAGCCTGGGCC	0.682000													36	67					0	0	1	0	0
DNPEP	23549	broad.mit.edu	37	2	220239650	220239650	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220239650G>A	ENST00000273075.4	-	14	1554	c.1334C>T	c.(1333-1335)cCc>cTc	p.P445L	DNPEP_ENST00000523282.1_Missense_Mutation_p.P453L|DNPEP_ENST00000490371.1_5'UTR|DNPEP_ENST00000373972.1_Missense_Mutation_p.P370L	NM_012100.2	NP_036232.2	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	435					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	GGCCAGTTGGGGGCTGCCTAA	0.607000													20	54					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284211	159284211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159284211G>A	ENST00000332217.5	-	1	238	c.239C>T	c.(238-240)cCc>cTc	p.P80L		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					AAGCATATGGGGAATGATGGC	0.493000													34	79					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48654501	48654501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48654501G>A	ENST00000263274.7	-	7	981	c.562C>T	c.(562-564)Cta>Tta	p.L188L	LIG1_ENST00000536218.1_Intron|LIG1_ENST00000599165.1_5'UTR|LIG1_ENST00000427526.2_Silent_p.L157L	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	188					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GAGGTCTTTAGGGGCTTGGGA	0.552000								Nucleotide excision repair (NER)					40	158					0	0	1	0	0
ART1	417	broad.mit.edu	37	11	3682615	3682615	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3682615G>A	ENST00000250693.1	+	4	959	c.858G>A	c.(856-858)aaG>aaA	p.K286K		NM_004314.2	NP_004305.2	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1	286					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|skin(1)	8		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	AGAAGTGCAAGTCTGGGCCTT	0.532000													26	57					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144875014	144875014	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144875014G>A	ENST00000356994.2	-	30	4047	c.4041C>T	c.(4039-4041)gcC>gcT	p.A1347A	SCRIB_ENST00000320476.3_Silent_p.A1347A|SCRIB_ENST00000377533.3_Silent_p.A1266A|SCRIB_ENST00000546337.1_5'UTR	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	1347	Pro-rich.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GCTCCGGGGAGGCTGCAGGCC	0.711000													10	18					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168105525	168105525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168105525G>A	ENST00000409195.1	+	9	7712	c.7623G>A	c.(7621-7623)aaG>aaA	p.K2541K	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Silent_p.K2541K|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.K2319K	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2366					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAAAATTTAAGACACCTTTAA	0.318000													43	125					0	0	1	0	0
SRD5A2	6716	broad.mit.edu	37	2	31805774	31805774	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31805774C>T	ENST00000405650.1	-	0	362							P31213	S5A2_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)						androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity					Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GGCGAGGATCCCCGCGGGCAC	0.667000													5	17					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172766859	172766859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172766859C>T	ENST00000351008.3	-	3	821	c.638G>A	c.(637-639)gGa>gAa	p.G213E		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	213					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AAATGGTTCTCCCAGAACTGC	0.348000													12	38					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1325382	1325382	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1325382G>A	ENST00000381567.3	-	3	292	c.293C>T	c.(292-294)tCc>tTc	p.S98F	CRLF2_ENST00000381566.1_Missense_Mutation_p.S98F|CRLF2_ENST00000467626.1_5'UTR	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	98						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				ATTCCTGATGGAGAAATAGAG	0.512000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								20	98					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813932	106813932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106813932G>A	ENST00000407775.2	+	8	1872	c.1622G>A	c.(1621-1623)aGc>aAc	p.S541N	ZFPM2_ENST00000520492.1_Missense_Mutation_p.S409N|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S272N|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S409N|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	541					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GTCATTTACAGCCCTTTGATG	0.453000													53	95					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21712328	21712328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21712328G>A	ENST00000388958.3	+	10	961	c.960G>A	c.(958-960)agG>agA	p.R320R	OTOA_ENST00000388956.4_Silent_p.R241R|OTOA_ENST00000286149.4_Silent_p.R320R	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	320					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		TTAACATGAGGAATACCTCCA	0.522000													17	46					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92730808	92730808	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92730808C>T	ENST00000379958.2	-	3	4872	c.4603G>A	c.(4603-4605)Gaa>Aaa	p.E1535K		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1535						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CAATTGTTTTCAGCTCGACCT	0.373000													19	45					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39965022	39965022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39965022C>T	ENST00000599117.1	+	28	3167	c.2800C>T	c.(2800-2802)Ccg>Tcg	p.P934S	SUPT5H_ENST00000359191.6_Missense_Mutation_p.P930S|SUPT5H_ENST00000402194.2_Missense_Mutation_p.P930S|SUPT5H_ENST00000598725.1_Missense_Mutation_p.P934S|SUPT5H_ENST00000432763.2_Missense_Mutation_p.P934S			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	934	10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y, motif CTR2.|Pro-rich.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCACCCTACACCGTCGCCCAT	0.632000											OREG0025462	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	38					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166976311	166976311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:166976311C>T	ENST00000061240.2	+	13	2255	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	TLL1_ENST00000507499.1_Silent_p.F559F	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	536	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TAGGGCGTTTCTGTGGTTATG	0.398000													27	69					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222217	140222217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140222217C>T	ENST00000531613.1	+	1	1311	c.1311C>T	c.(1309-1311)gcC>gcT	p.A437A	PCDHA8_ENST00000378123.3_Silent_p.A437A|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGTGGGCCACCGCCAGCT	0.657000													33	32					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82319705	82319705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:82319705C>T	ENST00000376552.2	+	9	1635	c.617C>T	c.(616-618)tCa>tTa	p.S206L	TLE4_ENST00000376520.4_Intron|TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000265284.6_Missense_Mutation_p.S181L|TLE4_ENST00000376544.3_Intron|TLE4_ENST00000376537.4_Missense_Mutation_p.S206L	NM_007005.3	NP_008936.2	O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CAGAGCTCTTCAGTATCCCCA	0.403000													72	166					0	0	1	0	0
KLRD1	3824	broad.mit.edu	37	12	10462275	10462275	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10462275G>A	ENST00000381908.3	+	3	411	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K	KLRD1_ENST00000538997.1_3'UTR|KLRD1_ENST00000543777.1_Intron|KLRD1_ENST00000350274.5_Missense_Mutation_p.E20K|KLRD1_ENST00000381907.4_Missense_Mutation_p.E51K|KLRD1_ENST00000336164.4_Missense_Mutation_p.E51K|KLRD1_ENST00000543420.1_Missense_Mutation_p.E51K			Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D, member 1	51					cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	10						ACCCAACATAGAACTCCAGAA	0.333000													5	39					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240374523	240374523	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240374523G>A	ENST00000319653.9	+	6	4283	c.4053G>A	c.(4051-4053)acG>acA	p.T1351T		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1351	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCTCAAAGACGAAGGCTAAAC	0.338000													40	109					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105842748	105842748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:105842748G>A	ENST00000282499.5	+	15	2848	c.2402G>A	c.(2401-2403)gGa>gAa	p.G801E	GRIA4_ENST00000533094.1_Intron|GRIA4_ENST00000525187.1_Intron|GRIA4_ENST00000530497.1_Missense_Mutation_p.G801E|GRIA4_ENST00000393127.2_Intron	NM_000829.3	NP_000820.3	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	801					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	AAGGACTCTGGAAGCAAGGTC	0.458000													20	57					0	0	1	0	0
SLC6A7	6534	broad.mit.edu	37	5	149578866	149578866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149578866C>T	ENST00000230671.2	+	5	1031	c.660C>T	c.(658-660)tgC>tgT	p.C220C	SLC6A7_ENST00000524041.1_Silent_p.C220C	NM_014228.3	NP_055043.2	Q99884	SC6A7_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 7	220						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)|stomach(1)	16		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	TCTGCCTCTGCCTGCTGCTGG	0.637000													17	68					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23177458	23177458	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:23177458G>A	ENST00000389131.3	-	8	1779	c.1410C>T	c.(1408-1410)atC>atT	p.I470I		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	470	SRCR 4.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		TGGCCTCCACGATGCCCCAGT	0.657000													27	59					0	0	1	0	0
FLVCR1	28982	broad.mit.edu	37	1	213046096	213046096	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:213046096C>T	ENST00000366971.4	+	3	1158	c.960C>T	c.(958-960)tcC>tcT	p.S320S		NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	320					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		AAGAGTACTCCTATAAGAAAT	0.383000													14	54					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141044607	141044607	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141044607C>T	ENST00000239440.4	-	19	2747	c.2682G>A	c.(2680-2682)tgG>tgA	p.W894*	ARAP3_ENST00000512390.1_5'UTR|ARAP3_ENST00000508305.1_Nonsense_Mutation_p.W796*|ARAP3_ENST00000513878.1_Nonsense_Mutation_p.W556*	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	894					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding	p.W894*(1)		NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TGGCTGCGTTCCATGCCGTGA	0.652000											OREG0016871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	22					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1427378	1427378	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:1427378G>A	ENST00000446702.2	+	20	3228	c.2601G>A	c.(2599-2601)acG>acA	p.T867T	CNTN6_ENST00000539053.1_Silent_p.T795T|CNTN6_ENST00000350110.2_Silent_p.T867T			Q9UQ52	CNTN6_HUMAN	contactin 6	867	Fibronectin type-III 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAAACATCACGGGGCTGAAAG	0.428000													50	128					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150432701	150432701	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150432701C>T	ENST00000401000.4	+	8	1306	c.1241C>T	c.(1240-1242)tCc>tTc	p.S414F	RPRD2_ENST00000369068.4_Missense_Mutation_p.S440F|RPRD2_ENST00000539519.1_Missense_Mutation_p.S414F|RPRD2_ENST00000492220.1_3'UTR			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	440							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CTTTCCCCTTCCCCAGCATTG	0.448000													10	24					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150721387	150721387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150721387C>T	ENST00000605938.1	-	1	199	c.124G>A	c.(124-126)Gga>Aga	p.G42R	ATG9B_ENST00000377974.2_Missense_Mutation_p.G42R|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_5'UTR|ATG9B_ENST00000605952.1_Missense_Mutation_p.G42R	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	42	Pro-rich.				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCCAGGTCCCCGGCATGAA	0.672000													4	9					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117552767	117552767	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117552767C>T	ENST00000374045.4	-	4	834	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	TNFSF15_ENST00000374044.1_Missense_Mutation_p.E164K	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	241					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						GTTTTATCTTCTTTTGTGTAA	0.428000													33	121					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678098	25678098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25678098G>A	ENST00000382051.3	+	13	1850	c.1800G>A	c.(1798-1800)ctG>ctA	p.L600L	SLC34A2_ENST00000503434.1_Silent_p.L599L|SLC34A2_ENST00000504570.1_Silent_p.L599L	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	600					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TGCGCTCGCTGAAGCCCTGGG	0.642000			T	ROS1	NSCLC								30	95					0	0	1	0	0
RARRES3	5920	broad.mit.edu	37	11	63313725	63313725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63313725C>T	ENST00000255688.3	+	4	540	c.492C>T	c.(490-492)gcC>gcT	p.A164A	RARRES3_ENST00000354445.2_Silent_p.A164A|RARRES3_ENST00000537871.1_3'UTR	NM_004585.3	NP_004576.2	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene induced) 3	164					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			kidney(1)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	6						AAGCGACAGCCTGAAGCAGCC	0.547000													44	100					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142021257	142021257	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142021257C>T	ENST00000390381.3	+	0	546																											AAGGAAACTTCCCTGGTCGAT	0.527000													21	37					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9084500	9084500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9084500C>T	ENST00000397910.4	-	1	7518	c.7315G>A	c.(7315-7317)Ggg>Agg	p.G2439R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2439	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGGAGCCCCCATCAAGAGAA	0.502000													4	42					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20623038	20623038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20623038C>T	ENST00000525748.1	+	2	640	c.367C>T	c.(367-369)Cct>Tct	p.P123S		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	123					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CTGTAAGATCCCTTTTCTGCG	0.672000													7	18					0	0	1	0	0
ZBED1	9189	broad.mit.edu	37	X	2408546	2408546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:2408546G>A	ENST00000381223.4	-	2	418	c.215C>T	c.(214-216)cCc>cTc	p.P72L	DHRSX_ENST00000334651.5_Intron|ZBED1_ENST00000381222.2_Missense_Mutation_p.P72L|ZBED1_ENST00000381218.3_Missense_Mutation_p.P72L	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	72						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GAATTCCTCGGGGTGGTTCTT	0.582000													30	96					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208804	58208804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58208804C>T	ENST00000377918.3	+	1	2150	c.2124C>T	c.(2122-2124)ctC>ctT	p.L708L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	708					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGCTGCCGCTCATCGTGACTC	0.592000													23	58					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126137038	126137038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:126137038C>T	ENST00000299308.3	+	8	1959	c.1951C>T	c.(1951-1953)Ctg>Ttg	p.L651L	TMEM132B_ENST00000535886.1_Silent_p.L163L	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	651						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GGTGATTGTCCTGGATGACCG	0.582000													8	40					0	0	1	0	0
OR51M1	390059	broad.mit.edu	37	11	5411015	5411015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5411015G>A	ENST00000328611.3	+	1	409	c.387G>A	c.(385-387)atG>atA	p.M129I	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001004756.2	NP_001004756.2	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M, member 1	129						integral to membrane	olfactory receptor activity			NS(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|upper_aerodigestive_tract(1)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCTCCTCATGATGTCCTTTG	0.488000													75	234					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30495438	30495438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30495438G>A	ENST00000356798.6	+	9	1040	c.860G>A	c.(859-861)gGa>gAa	p.G287E	RP11-297C4.2_ENST00000569459.1_RNA|ITGAL_ENST00000358164.5_Missense_Mutation_p.G204E|ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000454514.2_3'UTR	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	287	VWFA.				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TCACAGATTGGAAAGCATTTT	0.483000													20	170					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8698473	8698473	+	Silent	SNP	C	C	T	rs145869401	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:8698473C>T	ENST00000378641.3	+	14	1966	c.1491C>T	c.(1489-1491)ttC>ttT	p.F497F	PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Silent_p.F497F|PLCB1_ENST00000338037.6_Silent_p.F497F	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	497					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CCAGCATGTTCGAGCCCTCAT	0.522000													13	43					0	0	1	0	0
WIBG	84305	broad.mit.edu	37	12	56295662	56295662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56295662G>A	ENST00000408946.2	-	3	760	c.609C>T	c.(607-609)ggC>ggT	p.G203G	WIBG_ENST00000302533.6_5'UTR|WIBG_ENST00000398213.4_Silent_p.G202G	NM_032345.2	NP_115721.1	Q9BRP8	WIBG_HUMAN	within bgcn homolog (Drosophila)	203	eIF2A-like.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|exon-exon junction complex|nucleolus|nucleoplasm	protein binding|ribosome binding|RNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						GGCCTCAGAGGCCTAACTCCA	0.577000													81	263					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12656327	12656327	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12656327G>A	ENST00000425538.1	+	10	1922	c.1722G>A	c.(1720-1722)gaG>gaA	p.E574E	MYOCD_ENST00000395988.1_Silent_p.E478E|MYOCD_ENST00000343344.4_Silent_p.E574E	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	574					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGCAGGAAGAGGCTGTCTCCA	0.532000													28	25					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146256503	146256503	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:146256503G>C	ENST00000367503.3	-	12	3042	c.2644C>G	c.(2644-2646)Cgg>Ggg	p.R882G	SHPRH_ENST00000438092.2_Missense_Mutation_p.R882G|SHPRH_ENST00000275233.7_Missense_Mutation_p.R882G|SHPRH_ENST00000367505.2_Missense_Mutation_p.R882G	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	882					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CAGTAAGGCCGATAGAGAAGT	0.393000													27	29					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2437145	2437145	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2437145C>T	ENST00000452833.1	-	8	1133	c.1125G>A	c.(1123-1125)gtG>gtA	p.V375V	TRPM5_ENST00000528453.1_Silent_p.V373V|TRPM5_ENST00000155858.6_Silent_p.V373V|TRPM5_ENST00000533060.1_Silent_p.V373V			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	373						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCTTCCACTCCACGTCCCCAT	0.652000													3	8					0	0	1	0	0
ZNF132	7691	broad.mit.edu	37	19	58945977	58945977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58945977G>A	ENST00000254166.3	-	3	1234	c.834C>T	c.(832-834)atC>atT	p.I278I		NM_003433.3	NP_003424.3	P52740	ZN132_HUMAN	zinc finger protein 132	278						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(1)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TATTACCAAGGATTGATTTCT	0.443000													28	74					0	0	1	0	0
MKX	283078	broad.mit.edu	37	10	28024255	28024255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28024255G>A	ENST00000375790.5	-	4	829	c.397C>T	c.(397-399)Cga>Tga	p.R133*	MKX_ENST00000419761.1_Nonsense_Mutation_p.R133*			Q8IYA7	MKX_HUMAN	mohawk homeobox	133					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						TCTGGCTGTCGAACGGTATTC	0.368000													37	72					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53925647	53925647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53925647C>T	ENST00000371445.3	+	1	576	c.521C>T	c.(520-522)cCc>cTc	p.P174L		NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	174	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						TACCCTGGCCCCCTAGACCTG	0.716000													3	12					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117696924	117696924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117696924C>T	ENST00000317775.6	-	15	3064	c.2379G>A	c.(2377-2379)atG>atA	p.M793I	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.M793I	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	793	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CATATTCTTCCATGGACATCA	0.522000													12	41					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968384	28968384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28968384G>A	ENST00000359747.4	+	4	300	c.271G>A	c.(271-273)Ggg>Agg	p.G91R	DSG4_ENST00000308128.4_Missense_Mutation_p.G91R|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	91	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTCTGGAGTAGGGATTGATCG	0.403000													17	63					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73484038	73484038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73484038C>T	ENST00000314256.7	+	6	829	c.435C>T	c.(433-435)atC>atT	p.I145I	KIAA0195_ENST00000583795.1_3'UTR|KIAA0195_ENST00000579208.1_Intron|KIAA0195_ENST00000375248.5_Silent_p.I155I	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	145					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCAGGGAGATCCAGTGGCCCA	0.602000													14	49					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154744507	154744507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154744507G>A	ENST00000271915.3	-	3	1707	c.1392C>T	c.(1390-1392)ctC>ctT	p.L464L	KCNN3_ENST00000358505.2_Silent_p.L151L|KCNN3_ENST00000361147.4_Silent_p.L159L	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	469						integral to membrane	calmodulin binding	p.L464L(1)|p.L159L(1)		cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TGCTGAACACGAGCAGCACAG	0.557000													23	67					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197189708	197189708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197189708C>T	ENST00000260983.2	-	6	919	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	HECW2_ENST00000409111.1_5'UTR	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	246	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TCTTACCTCTCGGTGCCAAAT	0.512000													48	102					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723410	58723410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58723410C>T	ENST00000300079.5	+	7	962	c.912C>T	c.(910-912)tcC>tcT	p.S304S	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Silent_p.S273S	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	273						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	ATGAAGACTCCCGCAGATTTG	0.453000													21	77					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35927567	35927567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35927567C>T	ENST00000490799.1	-	15	2008	c.1655G>A	c.(1654-1656)gGg>gAg	p.G552E	SLC26A8_ENST00000355574.2_Missense_Mutation_p.G552E|SLC26A8_ENST00000394602.2_Missense_Mutation_p.G447E	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	552	STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						GATTTTCACCCCAGGAATGGT	0.383000													29	62					0	0	1	0	0
BBS2	583	broad.mit.edu	37	16	56519580	56519580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56519580G>A	ENST00000245157.5	-	16	2401	c.1981C>T	c.(1981-1983)Cgc>Tgc	p.R661C	BBS2_ENST00000568104.1_Missense_Mutation_p.R615C	NM_031885.3	NP_114091.3	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2	661					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)	26						TTGTTACAGCGAATTTTATAT	0.378000									Bardet-Biedl syndrome				24	209					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111957659	111957659	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111957659G>A	ENST00000369732.3	-	11	1519	c.1464C>T	c.(1462-1464)acC>acT	p.T488T		NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	488					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TCTCTCCAGGGGTCATGGACT	0.532000													17	75					0	0	1	0	0
ACY3	91703	broad.mit.edu	37	11	67410302	67410302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67410302C>T	ENST00000255082.3	-	8	1023	c.853G>A	c.(853-855)Gag>Aag	p.E285K	ACY3_ENST00000529256.1_Missense_Mutation_p.E164K	NM_080658.1	NP_542389.1	Q96HD9	ACY3_HUMAN	aspartoacylase (aminocyclase) 3	285					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding			endometrium(1)|lung(5)|prostate(2)	8					L-Aspartic Acid(DB00128)	TAGGCAGCCTCGTTAATGAAC	0.597000													36	54					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121643197	121643197	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121643197G>A	ENST00000489711.1	+	12	1390		c.e12-1		SLC15A2_ENST00000295605.2_Splice_Site	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2						protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AAATGTTTCAGGGGTTTTTTG	0.363000													56	158					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145439658	145439658	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145439658C>T	ENST00000511217.1	+	8	1837	c.1785C>T	c.(1783-1785)tcC>tcT	p.S595S	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Silent_p.S595S			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	595							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGATCCACTCCGCGGCCAGCT	0.632000													21	67					0	0	1	0	0
ATXN7	6314	broad.mit.edu	37	3	63981490	63981490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:63981490C>T	ENST00000398590.3	+	12	2545	c.1992C>T	c.(1990-1992)tcC>tcT	p.S664S	ATXN7_ENST00000487717.1_Silent_p.S664S|ATXN7_ENST00000538065.1_Silent_p.S664S|ATXN7_ENST00000295900.6_Silent_p.S664S|ATXN7_ENST00000484332.1_Silent_p.S519S	NM_001177387.1	NP_001170858.1	O15265	ATX7_HUMAN	ataxin 7	664	Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|stomach(1)|urinary_tract(3)	35		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		CGGTTCCTTCCTCCCCCATGT	0.512000													44	91					0	0	1	0	0
YPEL4	219539	broad.mit.edu	37	11	57413472	57413472	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57413472C>T	ENST00000524669.1	-	5	3088	c.366G>A	c.(364-366)aaG>aaA	p.K122K	YPEL4_ENST00000300022.3_Silent_p.K122K|AP000662.4_ENST00000530595.1_RNA|YPEL4_ENST00000544993.1_Silent_p.K122K|YPEL4_ENST00000534711.1_Silent_p.K122K			Q96NS1	YPEL4_HUMAN	yippee-like 4 (Drosophila)	122						nucleolus				lung(2)|skin(1)	3						AGCCGTTGTCCTTCACCATGT	0.547000													35	68					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42050073	42050073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42050073G>A	ENST00000372584.1	-	3	1410	c.396C>T	c.(394-396)tcC>tcT	p.S132S	HIVEP3_ENST00000247584.5_Silent_p.S132S|HIVEP3_ENST00000372583.1_Silent_p.S132S|HIVEP3_ENST00000429157.2_Silent_p.S132S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	132					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGGCCACGAAGGAGCCAGAGG	0.607000													51	106					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234112908	234112908	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234112908G>A	ENST00000359570.5	+	28	3076	c.3076G>A	c.(3076-3078)Gaa>Aaa	p.1026_1026insK	INPP5D_ENST00000455936.2_Missense_Mutation_p.790_790insK|INPP5D_ENST00000450745.1_Missense_Mutation_p.790_790insK			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	0	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GAAGGACCAGGAATCCCCCAA	0.637000													16	52					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374623	8374623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8374623C>T	ENST00000538603.1	-	7	1748	c.1190G>A	c.(1189-1191)cGg>cAg	p.R397Q	FAM90A1_ENST00000307435.6_Missense_Mutation_p.R397Q	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	397							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		TTCCAGTCTCCGAAAGAGCAC	0.637000													7	31					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41476767	41476767	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41476767C>T	ENST00000314992.5	-	10	1097	c.907G>A	c.(907-909)Gaa>Aaa	p.E303K	EXD1_ENST00000458580.2_Missense_Mutation_p.E361K	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	303					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						TGAAGCAGTTCCTCTGGCAGC	0.408000													32	68					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63955210	63955210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:63955210G>A	ENST00000443617.2	-	44	8961	c.8874C>T	c.(8872-8874)atC>atT	p.I2958I		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2958					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GTACCTCTGGGATCCACATTC	0.468000													8	63					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770514	31770514	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:31770514G>A	ENST00000240587.4	-	2	512	c.185C>T	c.(184-186)tCc>tTc	p.S62F		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	62					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GGCGGCCGGGGAGTTCTGGTA	0.587000													15	14					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519159	113519159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113519159C>T	ENST00000284601.3	-	4	2056	c.1988G>A	c.(1987-1989)gGa>gAa	p.G663E		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	663					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TCTTGATTTTCCCTGACTTTC	0.363000													61	164					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529732	5529732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5529732G>A	ENST00000311659.4	-	2	1204	c.1057C>T	c.(1057-1059)Ccc>Tcc	p.P353S	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	353										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGGACTGGGGGTTCTCGTGT	0.498000													46	96					0	0	1	0	0
CSRNP3	80034	broad.mit.edu	37	2	166536025	166536025	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166536025C>T	ENST00000314499.7	+	7	1896	c.1520C>T	c.(1519-1521)tCc>tTc	p.S507F	CSRNP3_ENST00000409420.1_Missense_Mutation_p.S539F|CSRNP3_ENST00000342316.4_Missense_Mutation_p.S507F	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	507					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						TGCTCCTCTTCCGAAAATGAT	0.512000													19	49					0	0	1	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43827047	43827047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43827047G>A	ENST00000420765.1	-	31	4309	c.4127C>T	c.(4126-4128)cCt>cTt	p.P1376L	PPIP5K1_ENST00000360301.4_Missense_Mutation_p.P1351L|PPIP5K1_ENST00000334933.4_Missense_Mutation_p.P1351L|PPIP5K1_ENST00000360135.4_Missense_Mutation_p.P1349L|PPIP5K1_ENST00000348806.6_Missense_Mutation_p.P1349L|PPIP5K1_ENST00000396923.3_Missense_Mutation_p.P1376L|PPIP5K1_ENST00000381885.1_Missense_Mutation_p.P1372L|PPIP5K1_ENST00000381879.4_Missense_Mutation_p.P1352L	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1376					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						GACCTCCTCAGGGATCTCTTC	0.547000													49	97					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48390632	48390632	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48390632C>T	ENST00000224600.4	-	1	359	c.246G>A	c.(244-246)ctG>ctA	p.L82L		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	82	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GAGGATCGTTCAGGGAGCTCT	0.612000													31	59					0	0	1	0	0
IGHV4-4	28401	broad.mit.edu	37	14	106478215	106478215	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106478215G>A	ENST00000390596.2	-	0	306																											GACTCTTGAGGGAGGGGTTGT	0.572000													11	98					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61028352	61028352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61028352C>T	ENST00000373867.3	-	9	1119	c.654G>A	c.(652-654)cgG>cgA	p.R218R	FAM13C_ENST00000277705.6_Silent_p.R322R|FAM13C_ENST00000419214.2_Silent_p.R301R|FAM13C_ENST00000435852.2_Silent_p.R301R|FAM13C_ENST00000422313.2_Silent_p.R301R|FAM13C_ENST00000468840.2_Silent_p.R218R|FAM13C_ENST00000373868.2_Silent_p.R301R|FAM13C_ENST00000442566.3_Silent_p.R322R	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	301										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTTCAAATTTCCGAATTTTCC	0.507000													23	49					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67051805	67051805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67051805C>T	ENST00000308595.5	+	18	1905	c.1615C>T	c.(1615-1617)Cgc>Tgc	p.R539C	ADRBK1_ENST00000526285.1_Intron|ADRBK1_ENST00000527176.1_3'UTR	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	539					activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCTGGAGGCTCGCAAGAAAGC	0.627000													7	46					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107732116	107732116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107732116G>A	ENST00000388781.3	-	14	1739	c.1656C>T	c.(1654-1656)ctC>ctT	p.L552L	LAMB4_ENST00000205386.4_Silent_p.L552L|LAMB4_ENST00000414450.2_Silent_p.L552L|LAMB4_ENST00000388780.3_Silent_p.L552L	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	552	Laminin EGF-like 5; truncated.|Laminin IV type B.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CTGCCTCGTAGAGATAGAAAT	0.493000													32	90					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039248	11039248	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039248C>T	ENST00000470054.1	-	0	955									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTTAGGTTCCTCTAACAACT	0.418000													22	412					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71056346	71056346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71056346C>T	ENST00000283228.2	-	11	1989	c.1537G>A	c.(1537-1539)Gga>Aga	p.G513R	PTPRR_ENST00000549308.1_Missense_Mutation_p.G268R|PTPRR_ENST00000537619.2_5'UTR|PTPRR_ENST00000378778.1_Missense_Mutation_p.G307R|PTPRR_ENST00000440835.2_Missense_Mutation_p.G268R|PTPRR_ENST00000342084.4_Missense_Mutation_p.G401R	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	513	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TCAACTTTTCCATATATCCCT	0.373000													15	56					0	0	1	0	0
USP25	29761	broad.mit.edu	37	21	17246733	17246733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:17246733C>T	ENST00000285681.2	+	23	3152	c.2783C>T	c.(2782-2784)tCc>tTc	p.S928F	USP25_ENST00000400183.2_Missense_Mutation_p.S966F|USP25_ENST00000351097.5_Missense_Mutation_p.S291F|USP25_ENST00000285679.6_Missense_Mutation_p.S896F			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	896					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TATATAGATTCCTTGCTGTTC	0.284000													26	51					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	54025254	54025254	+	Silent	SNP	C	C	T	rs148643501	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54025254C>T	ENST00000396328.1	-	2	332	c.93G>A	c.(91-93)acG>acA	p.T31T	WDR72_ENST00000559418.1_Silent_p.T31T|WDR72_ENST00000360509.5_Silent_p.T31T|WDR72_ENST00000557913.1_Silent_p.T31T	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	31										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		CAGTCACAATCGTTCGCTGGT	0.512000													40	110					0	0	1	0	0
IGHV5-51	28388	broad.mit.edu	37	14	107034732	107034732	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107034732C>T	ENST00000390626.2	-	0	406																											CTGTGTGTCTCGCACAGTAAT	0.597000													17	160					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64880991	64880991	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64880991C>T	ENST00000169565.3	+	4	783	c.783C>T	c.(781-783)ccC>ccT	p.P261P	CACNG5_ENST00000533854.1_Intron|CACNG5_ENST00000307139.3_Intron			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	0				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GCTCCTGTCCCCACGTCCACT	0.612000													23	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8997177	8997177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8997177G>A	ENST00000397910.4	-	60	41222	c.41019C>T	c.(41017-41019)tcC>tcT	p.S13673S	MUC16_ENST00000380951.5_Silent_p.S314S	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13675	SEA 11.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTTGAACAGGGACCTGAGCT	0.587000													25	67					0	0	1	0	0
IGF2BP2-AS1	646600	broad.mit.edu	37	3	185434297	185434297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185434297G>A	ENST00000296270.1	+	2	266	c.130G>A	c.(130-132)Gga>Aga	p.G44R	IGF2BP2_ENST00000457616.2_Intron|IGF2BP2_ENST00000346192.3_Intron|IGF2BP2_ENST00000382199.2_Intron|IGF2BP2_ENST00000421047.2_Intron																		all_cancers(143;1.5e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			CAGCTTTTGGGGAAGTGGGCT	0.458000													8	114					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87679348	87679348	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87679348G>A	ENST00000320005.5	-	6	704	c.657C>T	c.(655-657)ctC>ctT	p.L219L		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	219					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AGAGCCACAGGAGATAGAGTC	0.448000													9	29					0	0	1	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6094294	6094294	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:6094294G>A	ENST00000199389.6	-	2	306	c.160C>T	c.(160-162)Cta>Tta	p.L54L	EIF2AK1_ENST00000536084.1_5'UTR	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	54					negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GGCTGTTGTAGGGGTTCTTTT	0.393000													42	140					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56127839	56127839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56127839G>A	ENST00000303039.3	+	1	149	c.117G>A	c.(115-117)atG>atA	p.M39I		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					GGCTGACCATGGCAGGGAACC	0.498000													47	117					0	0	1	0	0
MTAP	4507	broad.mit.edu	37	9	21854633	21854633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21854633C>T	ENST00000380172.4	+	6	660	c.454C>T	c.(454-456)Ctt>Ttt	p.L152F	MTAP_ENST00000460874.2_Missense_Mutation_p.L169F|RP11-145E5.5_ENST00000404796.2_Intron|MTAP_ENST00000580900.1_Missense_Mutation_p.L152F	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	152					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	TTTCTAGGTTCTTATAGAGAC	0.443000													11	91					0	0	1	0	0
CT47A6	728062	broad.mit.edu	37	X	120094389	120094389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:120094389C>T	ENST00000443600.2	-	1	948	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K	CT47A5_ENST00000419194.2_Intron	NM_001080141.1	NP_001073610.1	Q5JQC4	CT47A_HUMAN	cancer/testis antigen family 47, member A6	232										large_intestine(1)|lung(4)	5						GTGGCTGGTTCCTCTGCGTCT	0.682000													249	2					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111671488	111671488	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111671488C>T	ENST00000431670.2	+	11	3112	c.2701C>T	c.(2701-2703)Cga>Tga	p.R901*	PHLDB2_ENST00000393925.3_Nonsense_Mutation_p.R901*|PHLDB2_ENST00000393923.3_Nonsense_Mutation_p.R885*|PHLDB2_ENST00000495180.1_Intron|PHLDB2_ENST00000481953.1_Nonsense_Mutation_p.R858*|PHLDB2_ENST00000412622.1_Nonsense_Mutation_p.R858*	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	901						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TACTTTGCCTCGAAAGAAAAC	0.443000													31	82					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151376574	151376574	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151376574C>T	ENST00000370314.4	-	7	915	c.677G>A	c.(676-678)gGa>gAa	p.G226E	GABRA3_ENST00000370311.1_Missense_Mutation_p.G226E|GABRA3_ENST00000535043.1_Missense_Mutation_p.G226E	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	226					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTTGTTCTTTCCGAGAGTCCA	0.443000													56	35					0	0	1	0	0
C9orf24	84688	broad.mit.edu	37	9	34381390	34381390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34381390C>T	ENST00000297623.2	-	4	647	c.449G>A	c.(448-450)aGg>aAg	p.R150K	C9orf24_ENST00000379124.1_Missense_Mutation_p.R15K|C9orf24_ENST00000379126.3_Missense_Mutation_p.R15K|C9orf24_ENST00000379133.3_Missense_Mutation_p.R15K|C9orf24_ENST00000379127.1_Missense_Mutation_p.R15K	NM_032596.3	NP_115985.2	Q8NCR6	CI024_HUMAN	chromosome 9 open reading frame 24	150										endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)		CCGCTCCGGCCTAGGAGGGCA	0.617000													36	117					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50611760	50611760	+	Silent	SNP	C	C	T	rs74987565	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50611760C>T	ENST00000444124.2	-	2	224	c.24G>A	c.(22-24)agG>agA	p.R8R	DDC_ENST00000357936.5_Silent_p.R8R|DDC_ENST00000380984.4_Silent_p.R8R|DDC_ENST00000431062.1_Silent_p.R8R|DDC_ENST00000426377.1_Silent_p.R8R	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	8					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CCTTCCCTCTCCTTCGGAATT	0.522000													58	154					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128608858	128608858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:128608858C>T	ENST00000335251.5	+	8	1388	c.1285C>T	c.(1285-1287)Cct>Tct	p.P429S		NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	429										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						TGAGAATGTTCCTCGTTTGGA	0.438000													31	96					0	0	1	0	0
TMEM173	340061	broad.mit.edu	37	5	138855874	138855874	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:138855874G>A	ENST00000330794.4	-	8	1445	c.1112C>T	c.(1111-1113)cCc>cTc	p.P371L		NM_198282.2	NP_938023.1	Q86WV6	TM173_HUMAN	transmembrane protein 173	371					activation of innate immune response|apoptosis|cellular response to exogenous dsRNA|defense response to virus|innate immune response|interferon-beta production|positive regulation of defense response to virus by host|positive regulation of protein binding|positive regulation of protein import into nucleus, translocation|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane|perinuclear region of cytoplasm|plasma membrane	protein homodimerization activity|protein kinase binding|transcription factor binding			endometrium(1)|kidney(1)|lung(6)|upper_aerodigestive_tract(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GAGAGGGAGGGGCTTTTCCAT	0.592000													3	6					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220108019	220108019	+	Silent	SNP	G	G	A	rs13388808		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220108019G>A	ENST00000295759.7	-	3	403	c.90C>T	c.(88-90)ttC>ttT	p.F30F	GLB1L_ENST00000356283.3_Silent_p.F30F|GLB1L_ENST00000392089.2_Silent_p.F30F|GLB1L_ENST00000409640.1_Silent_p.F30F			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	30					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TATCCACTACGAACGACCGAG	0.602000													32	75					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348083	220348083	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220348083G>A	ENST00000312358.7	+	30	6030	c.5898G>A	c.(5896-5898)ggG>ggA	p.G1966G	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1966					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CAGAGACTGGGGCTGCCACCC	0.701000													6	18					0	0	1	0	0
PMCH	5367	broad.mit.edu	37	12	102591323	102591323	+	Missense_Mutation	SNP	C	C	T	rs141964854		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102591323C>T	ENST00000329406.4	-	1	300	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K		NM_002674.2	NP_002665.2	P20382	MCH_HUMAN	pro-melanin-concentrating hormone	76					cell differentiation|neuropeptide signaling pathway|spermatogenesis|synaptic transmission		melanin-concentrating hormone activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	6						TTTTCCTCTTCGTTCATGAAA	0.348000													24	84					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52540749	52540749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52540749G>A	ENST00000321725.6	+	18	1948	c.1872G>A	c.(1870-1872)agG>agA	p.R624R		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	624	FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CGCTGCAGAGGGTAGACGTGA	0.692000													5	22					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130059685	130059685	+	Silent	SNP	C	C	T	rs142848651	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130059685C>T	ENST00000278742.5	+	5	910	c.492C>T	c.(490-492)caC>caT	p.H164H		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	164					proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	TCCCGCAGCACCTGGTGGAGG	0.677000													50	110					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43531170	43531170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43531170G>A	ENST00000220420.5	-	9	1197	c.1190C>T	c.(1189-1191)tCg>tTg	p.S397L	TGM5_ENST00000349114.4_Missense_Mutation_p.S315L	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	397					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	ATTCACCATCGAAAACACAAA	0.527000													14	55					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145442113	145442113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145442113C>T	ENST00000511217.1	+	9	2091	c.2039C>T	c.(2038-2040)tCc>tTc	p.S680F	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Missense_Mutation_p.S680F			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	680							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAAGCAGCGTCCTTGGGCCCA	0.597000													8	78					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71277022	71277022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71277022C>T	ENST00000398531.1	+	1	414	c.389C>T	c.(388-390)tCc>tTc	p.S130F	KRTAP5-10_ENST00000376536.4_Missense_Mutation_p.S82F	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	130	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGTGGGGGCTCCAAGGGGGGC	0.652000													48	180					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110819862	110819862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110819862G>A	ENST00000282356.4	+	11	1518	c.1120G>A	c.(1120-1122)Gaa>Aaa	p.E374K	CAMK4_ENST00000512890.1_3'UTR|CAMK4_ENST00000512453.1_Missense_Mutation_p.E374K	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	374					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		AGCTATTCCAGAAGGAGAGAA	0.537000													15	75					0	0	1	0	0
KITLG	4254	broad.mit.edu	37	12	88910190	88910190	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:88910190G>A	ENST00000347404.5	-	5	1013	c.441C>T	c.(439-441)tcC>tcT	p.S147S	KITLG_ENST00000357116.4_Intron|KITLG_ENST00000228280.5_Silent_p.S147S|KITLG_ENST00000378535.4_5'UTR	NM_003994.5	NP_003985.2	P21583	SCF_HUMAN	KIT ligand	147					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)	9						AGGCATCAATGGATCTATTAA	0.358000									Testicular Cancer, Familial Clustering of				22	73					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94055164	94055164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94055164G>A	ENST00000297268.6	+	44	3409	c.2938G>A	c.(2938-2940)Gaa>Aaa	p.E980K		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	980				E -> V (in Ref. 21; AAA51996).	axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AAACCGTGGTGAAACTGTAAG	0.577000										HNSCC(75;0.22)			3	13					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17434544	17434544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:17434544C>T	ENST00000262545.2	+	9	1358	c.1043C>T	c.(1042-1044)tCt>tTt	p.S348F	PCSK2_ENST00000536609.1_Missense_Mutation_p.S313F|PCSK2_ENST00000377899.1_Missense_Mutation_p.S329F	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	348	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAGAGCTGCTCTTCCACCTTG	0.597000													25	70					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91844621	91844621	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:91844621G>A	ENST00000370425.3	-	9	1255	c.1158_splice	c.e9+1	p.P386_splice	HFM1_ENST00000370424.3_Splice_Site_p.P65_splice|HFM1_ENST00000294696.5_5'UTR	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	386	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AATACCTACTGGAGTTGTCAT	0.264000													18	27					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78401191	78401191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:78401191C>T	ENST00000397909.2	+	8	2046	c.1873C>T	c.(1873-1875)Ccg>Tcg	p.P625S	NAV3_ENST00000266692.7_Missense_Mutation_p.P625S|NAV3_ENST00000536525.2_Missense_Mutation_p.P625S|NAV3_ENST00000228327.6_Missense_Mutation_p.P625S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	625						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACATAGCCACCCGAATACCGC	0.478000										HNSCC(70;0.22)			33	104					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348124	140348124	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348124C>T	ENST00000289269.5	+	1	2305	c.1773C>T	c.(1771-1773)ttC>ttT	p.F591F	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		591					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCAGCCTTCGAGATGGTGC	0.517000													19	33					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62748477	62748477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62748477G>A	ENST00000377871.3	-	6	1283	c.1017C>T	c.(1015-1017)ttC>ttT	p.F339F	SLC22A6_ENST00000537349.1_5'UTR|SLC22A6_ENST00000458333.2_Silent_p.F339F|SLC22A6_ENST00000421062.2_Silent_p.F339F|SLC22A6_ENST00000360421.4_Silent_p.F339F	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	339					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						AGAGGCAGAGGAAGAGGTGGC	0.617000													21	50					0	0	1	0	0
IGHV1-45	28466	broad.mit.edu	37	14	106963149	106963149	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106963149C>T	ENST00000390621.2	-	0	190																											AAGGTGTATCCGGAAGCCTTG	0.572000													53	101					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84050173	84050173	+	Silent	SNP	G	G	A	rs113073498	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84050173G>A	ENST00000299709.3	-	8	1112	c.1113C>T	c.(1111-1113)atC>atT	p.I371I		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	371					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						TGATGCTGACGATCTCGCTGA	0.592000													16	61					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537447	55537447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55537447G>A	ENST00000220676.1	+	4	1153	c.1005G>A	c.(1003-1005)atG>atA	p.M335I		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	335					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.M335I(1)		NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CAGTTGAGATGAAAGTTCGAT	0.313000													19	35					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2808778	2808778	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2808778G>A	ENST00000520002.1	-	67	10617	c.10062C>T	c.(10060-10062)ttC>ttT	p.F3354F	CSMD1_ENST00000542608.1_Silent_p.F3176F|CSMD1_ENST00000537824.1_Silent_p.F3353F|CSMD1_ENST00000602723.1_Silent_p.F3177F|CSMD1_ENST00000400186.3_Silent_p.F3177F|CSMD1_ENST00000602557.1_Silent_p.F3354F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3354						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGAATTGACGAAAAAGACAT	0.413000													6	17					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15809077	15809077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15809077C>T	ENST00000338282.6	-	39	5663	c.5557G>A	c.(5557-5559)Gaa>Aaa	p.E1853K	MYH11_ENST00000300036.5_Missense_Mutation_p.E1853K|NDE1_ENST00000342673.5_Intron|MYH11_ENST00000452625.2_Missense_Mutation_p.E1860K|MYH11_ENST00000396324.3_Missense_Mutation_p.E1860K|NDE1_ENST00000396355.1_Intron|NDE1_ENST00000396354.1_Intron|MYH11_ENST00000576790.1_Missense_Mutation_p.E1853K	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1853					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						AGCAAGATTTCCTTCAGCTTC	0.607000			T	CBFB	AML								31	69					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28736065	28736065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28736065G>A	ENST00000257197.3	-	4	673	c.412C>T	c.(412-414)Cct>Tct	p.P138S	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Missense_Mutation_p.P138S	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	138	Cadherin 1.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GCTGGAATAGGAGCCCATCGT	0.408000													43	75					0	0	1	0	0
CROCC	9696	broad.mit.edu	37	1	17280797	17280797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17280797C>T	ENST00000375541.5	+	22	3335	c.3266C>T	c.(3265-3267)tCc>tTc	p.S1089F	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	1089					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GCCACCATCTCCCTGGAGATG	0.627000													37	97					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427724	119427724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119427724G>A	ENST00000369429.3	-	8	1449	c.1440C>T	c.(1438-1440)gtC>gtT	p.V480V	TBX15_ENST00000207157.3_Silent_p.V374V			Q96SF7	TBX15_HUMAN	T-box 15	480						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CTGCCTGCATGACATACTGAA	0.567000													12	28					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960771	73960771	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73960771C>T	ENST00000373468.1	-	3	4272	c.3621G>A	c.(3619-3621)ggG>ggA	p.G1207G	KIAA2022_ENST00000055682.5_Silent_p.G1207G			Q5QGS0	K2022_HUMAN	KIAA2022	1207					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GTTTTTCAATCCCCTTGTTGT	0.438000													28	18					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32526597	32526597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32526597C>T	ENST00000286827.3	-	18	3610	c.3139G>A	c.(3139-3141)Gag>Aag	p.E1047K	TIAM1_ENST00000541036.1_Missense_Mutation_p.E987K	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1047	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TCCAGGAGCTCGCAGATCACC	0.582000													30	18					0	0	1	0	0
POTEG	404785	broad.mit.edu	37	14	19553749	19553749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:19553749G>A	ENST00000409832.3	+	1	385	c.333G>A	c.(331-333)ggG>ggA	p.G111G		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	111										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GCTGCAGGGGGAGCGGCAAGA	0.597000													100	316					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375047	113375047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113375047G>A	ENST00000316407.4	-	7	5892	c.5482C>T	c.(5482-5484)Ctc>Ttc	p.L1828F	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.L1828F	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1828					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGATCACTGAGGTGAGGGGCA	0.473000													47	167					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45024569	45024569	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45024569G>A	ENST00000454753.1	-	0	1247							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				AGACCTCACAGGCATAGGGCC	0.642000													20	47					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115130449	115130449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115130449G>A	ENST00000393274.1	-	19	3181	c.2556C>T	c.(2554-2556)ttC>ttT	p.F852F	DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Silent_p.F795F|DENND2C_ENST00000393277.1_Silent_p.F740F	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	852	dDENN.									NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGACTTACGGAATGGTTCCC	0.483000													17	49					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58107029	58107029	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58107029G>A	ENST00000357272.4	+	20	3090	c.2925G>A	c.(2923-2925)ggG>ggA	p.G975G	FLNB_ENST00000358537.3_Silent_p.G975G|FLNB_ENST00000295956.4_Silent_p.G975G|FLNB_ENST00000429972.2_Silent_p.G975G|FLNB_ENST00000490882.1_Silent_p.G975G|FLNB_ENST00000348383.5_Silent_p.G975G|FLNB_ENST00000419752.2_Silent_p.G806G|FLNB_ENST00000493452.1_Silent_p.G806G			O75369	FLNB_HUMAN	filamin B, beta	975					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GAGGCCAGGGGAAGCTGGACG	0.587000													46	110					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064099	6064099	+	Silent	SNP	G	G	A	rs149678000	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6064099G>A	ENST00000409021.3	-	10	1949	c.1500C>T	c.(1498-1500)cgC>cgT	p.R500R	JAKMIP1_ENST00000410077.2_Silent_p.R335R|JAKMIP1_ENST00000409831.1_Silent_p.R500R|JAKMIP1_ENST00000282924.5_Silent_p.R500R|JAKMIP1_ENST00000409371.3_Silent_p.R315R	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	500	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GGGCGTAGGCGCGTTGCAGGG	0.642000													26	72					0	0	1	0	0
ZNF792	126375	broad.mit.edu	37	19	35449721	35449721	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35449721G>A	ENST00000404801.1	-	4	1424	c.1038C>T	c.(1036-1038)ttC>ttT	p.F346F	ZNF792_ENST00000605484.1_Silent_p.F279F	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TTCGGCTGAAGAATTTCCCAC	0.507000													15	32					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531893	50531893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50531893G>A	ENST00000374144.3	+	3	1591	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K	C10orf71_ENST00000323868.4_Missense_Mutation_p.E435K			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	435										endometrium(1)	1						GGAACCCAATGAACATTATGA	0.512000													27	87					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100226909	100226909	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100226909C>G	ENST00000524871.1	+	25	3551	c.3261C>G	c.(3259-3261)gtC>gtG	p.V1087V	CNTN5_ENST00000279463.3_Silent_p.V1087V|CNTN5_ENST00000528682.1_Silent_p.V1087V|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000418526.2_Silent_p.V1013V	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	1087					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CGTCATCAGTCACCTTGCTCT	0.418000													6	20					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26866495	26866495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:26866495G>A	ENST00000541819.2	-	5	697	c.595C>T	c.(595-597)Ctt>Ttt	p.L199F	GABRB3_ENST00000545868.1_Missense_Mutation_p.L58F|GABRB3_ENST00000400188.3_Missense_Mutation_p.L72F|GABRB3_ENST00000299267.4_Missense_Mutation_p.L143F|GABRB3_ENST00000311550.5_Missense_Mutation_p.L143F			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	143					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCAGGGTGAAGACGGATCATG	0.478000													34	105					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56026089	56026089	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:56026089C>T	ENST00000288221.6	-	11	2506	c.2251G>A	c.(2251-2253)Gag>Aag	p.E751K		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	751						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		ATTTACCTCTCCAGTTCTGCG	0.483000													9	152					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848257	73848257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73848257G>A	ENST00000523207.1	+	3	1255	c.667G>A	c.(667-669)Gaa>Aaa	p.E223K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	223					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GGAAACGGACGAATTTGGACA	0.478000													54	113					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45817352	45817352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45817352C>T	ENST00000358525.4	-	4	598	c.483G>A	c.(481-483)caG>caA	p.Q161Q	SLC6A20_ENST00000353278.4_Silent_p.Q161Q|SLC6A20_ENST00000456124.2_Silent_p.Q161Q	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	161					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CCCCGTTCTCCTGGAGGGACG	0.607000													40	143					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42231011	42231011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42231011G>A	ENST00000541110.1	-	8	2499	c.1931C>T	c.(1930-1932)cCc>cTc	p.P644L	TRERF1_ENST00000354325.2_Intron|TRERF1_ENST00000340840.2_Intron|TRERF1_ENST00000372917.4_Intron|TRERF1_ENST00000372922.4_Intron			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	628	Interacts with CREBBP.|Pro-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGGCGTGCGGGGGGCAGCCCC	0.647000													35	56					0	0	1	0	0
SMYD1	150572	broad.mit.edu	37	2	88387520	88387520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:88387520G>A	ENST00000419482.2	+	3	539	c.454G>A	c.(454-456)Gac>Aac	p.D152N	SMYD1_ENST00000444564.2_Missense_Mutation_p.D152N|SMYD1_ENST00000438570.1_Intron|SMYD1_ENST00000468008.1_3'UTR	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	152	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						GGTGGACGTGGACACATTCTT	0.622000													18	61					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62652709	62652709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:62652709G>A	ENST00000337910.5	-	5	678	c.341C>T	c.(340-342)tCc>tTc	p.S114F	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.S114F	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	114	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					ATGATTTAGGGAATTGGGATT	0.408000													30	110					0	0	1	0	0
RPAP1	26015	broad.mit.edu	37	15	41819639	41819639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41819639G>A	ENST00000304330.4	-	12	1709	c.1593C>T	c.(1591-1593)gcC>gcT	p.A531A	RPAP1_ENST00000561603.1_Silent_p.A531A	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	531						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CATCATGTCGGGCCAGGTCAG	0.552000													21	75					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143104721	143104721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143104721C>T	ENST00000275815.3	-	2	219	c.133G>A	c.(133-135)Gat>Aat	p.D45N		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	45						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TTTGGGGGATCCAGCAGCCAG	0.562000													34	368					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262588	140262588	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140262588C>T	ENST00000289272.2	+	1	735	c.735C>T	c.(733-735)tcC>tcT	p.S245S	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.S245S|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTACCAATCCGTTTATAAAG	0.453000													34	96					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94670698	94670698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94670698C>T	ENST00000260526.6	-	7	798	c.616G>A	c.(616-618)Gag>Aag	p.E206K	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.E206K	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	206					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		AAAGCCAGCTCGATAGAGTCA	0.338000													14	53					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57017042	57017042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:57017042C>T	ENST00000370706.4	+	12	3020	c.2776C>T	c.(2776-2778)Ccg>Tcg	p.P926S	RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Missense_Mutation_p.P878S|RP11-203B9.4_ENST00000589549.1_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.P926S|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000586466.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000589263.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	926					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTGGAAGCCTCCGCTCAACTG	0.363000													29	59					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15296161	15296161	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15296161G>A	ENST00000263388.2	-	14	2278	c.2203C>T	c.(2203-2205)Cga>Tga	p.R735*		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	735	EGF-like 19.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CAGGCGTCTCGGGCCAGGCTC	0.677000													8	20					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620138	7620138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:7620138C>T	ENST00000486284.1	+	8	1819	c.1545C>T	c.(1543-1545)gtC>gtT	p.V515V	GRM7_ENST00000357716.4_Silent_p.V515V|GRM7_ENST00000403881.1_Silent_p.V515V|GRM7_ENST00000402647.2_Silent_p.V515V|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000389336.4_Silent_p.V515V	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	515					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GTAAAGGAGTCCGAGAGATAC	0.463000													18	55					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1953695	1953695	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1953695C>T	ENST00000382722.5	-	25	2705	c.2342_splice	c.e25-1	p.R781_splice	CACNA2D4_ENST00000588077.1_Splice_Site_p.R717_splice|CACNA2D4_ENST00000539048.2_5'UTR|CACNA2D4_ENST00000585708.1_Splice_Site_p.R717_splice|CACNA2D4_ENST00000586184.1_Splice_Site_p.R781_splice|CACNA2D4_ENST00000587995.1_Splice_Site_p.R756_splice|CACNA2D4_ENST00000585732.1_Splice_Site_p.R642_splice	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	781						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TCAGGAACTTCCTGCAAGGAG	0.562000													8	38					0	0	1	0	0
SPRY2	10253	broad.mit.edu	37	13	80911411	80911411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:80911411G>A	ENST00000377102.1	-	2	1407	c.430C>T	c.(430-432)Cct>Tct	p.P144S	SPRY2_ENST00000540649.1_Missense_Mutation_p.P144S|SPRY2_ENST00000377104.3_Missense_Mutation_p.P144S			O43597	SPY2_HUMAN	sprouty homolog 2 (Drosophila)	144					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	12	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		TCAGCAACAGGCCCGGAGGAG	0.562000													21	57					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37690748	37690748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37690748C>T	ENST00000248901.6	+	3	337	c.150C>T	c.(148-150)ttC>ttT	p.F50F	CYTH4_ENST00000402997.1_Silent_p.F50F|CYTH4_ENST00000405206.3_Silent_p.F50F|CYTH4_ENST00000439667.1_3'UTR	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	50					regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						TCGACTGCTTCGAGAGTGCGG	0.592000													35	73					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124305219	124305219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124305219C>T	ENST00000409039.3	+	23	3764	c.3739C>T	c.(3739-3741)Cct>Tct	p.P1247S		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1247	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTTCGATCTTCCTATTACAAT	0.443000													21	76					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10468850	10468850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10468850G>A	ENST00000382483.3	-	4	2981	c.2758C>T	c.(2758-2760)Cgg>Tgg	p.R920W		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	920					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GACAGCCCCCGAGACCCCGCA	0.706000													4	32					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846645	47846645	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47846645G>A	ENST00000339488.4	-	3	1968	c.1935C>T	c.(1933-1935)ccC>ccT	p.P645P		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	645						integral to membrane	hedgehog receptor activity										AGACAAAGGAGGGGTTGAACA	0.473000													34	158					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165182897	165182897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165182897G>A	ENST00000342310.3	-	5	1032	c.650C>T	c.(649-651)tCc>tTc	p.S217F	LMX1A_ENST00000367893.4_Missense_Mutation_p.S217F|LMX1A_ENST00000294816.2_Missense_Mutation_p.S217F	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	217						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					GGGCTTGGAGGATACTTCAAA	0.562000													60	124					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057787	9057787	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9057787C>T	ENST00000397910.4	-	3	29862	c.29659G>A	c.(29659-29661)Gag>Aag	p.E9887K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9889	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGGTGGTCTCTTCAGAGGTG	0.453000													35	71					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54805108	54805108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54805108C>T	ENST00000306858.7	+	5	1455	c.1339C>T	c.(1339-1341)Cgg>Tgg	p.R447W		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	447										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTTTGCCAATCGGCTTGCGCA	0.458000													13	58					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95069791	95069791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95069791G>A	ENST00000371501.4	-	53	6255	c.6133C>T	c.(6133-6135)Ctc>Ttc	p.L2045F	MYOF_ENST00000371502.4_Missense_Mutation_p.L2035F|MYOF_ENST00000358334.5_Missense_Mutation_p.L2032F|MYOF_ENST00000359263.4_Missense_Mutation_p.L2045F			Q9NZM1	MYOF_HUMAN	myoferlin	2045					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AAAGAGTAGAGGAGCACGGCC	0.562000													19	33					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915173	46915173	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46915173C>T	ENST00000307522.3	-	1	1668	c.895G>A	c.(895-897)Gct>Act	p.A299T		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	299						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTATCTGCAGCCTCTCCCCCC	0.647000													71	153					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22348106	22348106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:22348106G>A	ENST00000344041.6	-	5	385	c.73C>T	c.(73-75)Caa>Taa	p.Q25*	RAPGEF5_ENST00000405243.1_Nonsense_Mutation_p.Q178*	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	0					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						TAAGTATCTTGAAAGTATAGA	0.294000													5	8					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69334630	69334630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69334630G>A	ENST00000305363.4	+	4	356	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	98	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TCCATTAAGGGAAGAATTTGT	0.294000													37	192					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19520786	19520786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:19520786C>T	ENST00000507958.1	-	12	2482	c.1492G>A	c.(1492-1494)Gaa>Aaa	p.E498K	CDH18_ENST00000382275.1_Missense_Mutation_p.E498K|CDH18_ENST00000274170.4_Missense_Mutation_p.E498K|CDH18_ENST00000502796.1_Missense_Mutation_p.E498K|CDH18_ENST00000511273.1_Missense_Mutation_p.E498K|CDH18_ENST00000506372.1_Missense_Mutation_p.E498K			Q13634	CAD18_HUMAN	cadherin 18, type 2	498	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TTAGAATTTTCACATACAATA	0.373000													22	57					0	0	1	0	0
ALDH9A1	223	broad.mit.edu	37	1	165652225	165652225	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165652225G>A	ENST00000354775.4	-	3	754	c.450C>T	c.(448-450)tcC>tcT	p.S150S	ALDH9A1_ENST00000461664.1_5'UTR|ALDH9A1_ENST00000538148.1_Silent_p.S56S	NM_000696.3	NP_000687.3	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9 family, member A1	126				C -> Q (in Ref. 7; AA sequence).	carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	21	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	TACCAGCCATGGATGCAGCCA	0.502000													28	50					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586169	20586169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20586169C>T	ENST00000315543.4	+	1	604	c.604C>T	c.(604-606)Ccc>Tcc	p.P202S		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTTTTGTGGTCCCAATGTGGT	0.438000													65	153					0	0	1	0	0
IGHV1-58	28464	broad.mit.edu	37	14	107078517	107078517	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107078517C>T	ENST00000390628.2	-	0	267																											CAACGACGATCCATCCTATCC	0.522000													17	106					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31457512	31457512	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31457512G>A	ENST00000322054.5	+	1	310	c.25G>A	c.(25-27)Gac>Aac	p.D9N	EHD3_ENST00000541626.1_Missense_Mutation_p.D9N	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	9					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					GGGTACGGACGACCGCCGGAG	0.642000													25	61					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12918988	12918988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12918988G>A	ENST00000240189.2	+	2	211	c.124G>A	c.(124-126)Gag>Aag	p.E42K		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	42										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTCTTCAGGGAGGCCTTCAG	0.597000													43	213					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887664	97887664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97887664G>A	ENST00000356526.2	+	1	121	c.121G>A	c.(121-123)Ggg>Agg	p.G41R		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						CACCATCATGGGGAATCTTGG	0.408000													89	229					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42279563	42279563	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42279563C>T	ENST00000399518.3	-	17	2328	c.1842G>A	c.(1840-1842)ccG>ccA	p.P614P	CTD-2382E5.1_ENST00000499478.2_RNA|PLA2G4E_ENST00000413860.2_Silent_p.P585P	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	602	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		CAGGCAGGATCGGCTCGTCTT	0.562000													10	24					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118511610	118511610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:118511610G>A	ENST00000359236.5	-	5	1389	c.1113C>T	c.(1111-1113)acC>acT	p.T371T		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	371	Ig-like C2-type 4.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						GGATAGTGAGGGTGGAGTTCT	0.587000													7	43					0	0	1	0	0
GDF9	2661	broad.mit.edu	37	5	132199880	132199880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132199880G>A	ENST00000378673.2	-	2	1212	c.346C>T	c.(346-348)Ctc>Ttc	p.L116F	GDF9_ENST00000464378.1_5'UTR|GDF9_ENST00000296875.2_Missense_Mutation_p.L116F			O60383	GDF9_HUMAN	growth differentiation factor 9	116					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGGGTGAAGAGCCGAACAGTG	0.483000													28	107					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71139691	71139691	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71139691G>A	ENST00000283228.2	-	6	1366	c.914C>T	c.(913-915)cCt>cTt	p.P305L	PTPRR_ENST00000549308.1_Missense_Mutation_p.P60L|PTPRR_ENST00000378778.1_Missense_Mutation_p.P99L|PTPRR_ENST00000440835.2_Missense_Mutation_p.P60L|PTPRR_ENST00000342084.4_Missense_Mutation_p.P193L	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	305					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TCGGCCTTGAGGGTCCACGAC	0.532000													24	37					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21954063	21954063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21954063C>T	ENST00000261200.4	-	38	4564	c.4565G>A	c.(4564-4566)gGa>gAa	p.G1522E		NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1522	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.G1522E(1)		NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TAAAATATTTCCTCGCTTCAT	0.408000													8	70					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56297165	56297165	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56297165C>T	ENST00000443188.1	-	12	3638	c.2928G>A	c.(2926-2928)ttG>ttA	p.L976L	NLRP11_ENST00000589824.2_Silent_p.L922L|NLRP11_ENST00000592953.1_Silent_p.L877L|NLRP11_ENST00000589093.1_Silent_p.L976L|NLRP11_ENST00000360133.3_Silent_p.L922L	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	976							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ACAGAAAGATCAAACTGGGTT	0.423000													32	82					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201752810	201752810	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201752810C>T	ENST00000367296.4	+	7	3054	c.2634C>T	c.(2632-2634)ctC>ctT	p.L878L	NAV1_ENST00000469130.1_3'UTR|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367295.1_Silent_p.L487L|NAV1_ENST00000367302.1_Silent_p.L891L|NAV1_ENST00000295624.6_Silent_p.L878L|NAV1_ENST00000367300.3_Silent_p.L878L|NAV1_ENST00000367297.4_Silent_p.L878L	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	878					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						ACCCCAAACTCTCAGGCCTGC	0.597000													35	72					0	0	1	0	0
MAK	4117	broad.mit.edu	37	6	10796537	10796537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:10796537C>T	ENST00000313243.2	-	9	1219	c.837G>A	c.(835-837)ttG>ttA	p.L279L	MAK_ENST00000536370.1_3'UTR|RP11-637O19.3_ENST00000480294.1_Intron|SYCP2L_ENST00000543878.1_Intron|MAK_ENST00000538030.1_Silent_p.L279L|MAK_ENST00000354489.2_Silent_p.L279L|MAK_ENST00000474039.1_Silent_p.L279L			P20794	MAK_HUMAN	male germ cell-associated kinase	279	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)	22	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				ATGGGTGTTTCAATGCCTATA	0.373000													15	63					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73169046	73169046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:73169046G>A	ENST00000545377.1	+	22	2965	c.2789G>A	c.(2788-2790)cGa>cAa	p.R930Q	ARHGEF28_ENST00000426542.2_Missense_Mutation_p.R930Q|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.R930Q|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.R930Q|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.R930Q|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.R617Q|ARHGEF28_ENST00000296794.6_Missense_Mutation_p.R930Q	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		GTGATCGACCGAATTGGAGAT	0.413000													6	18					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76924069	76924069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76924069C>T	ENST00000409709.3	+	47	6699	c.6427C>T	c.(6427-6429)Ccc>Tcc	p.P2143S	MYO7A_ENST00000409619.2_Missense_Mutation_p.P2094S|MYO7A_ENST00000605744.1_3'UTR|MYO7A_ENST00000458637.2_Missense_Mutation_p.P2103S	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	2143	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CCTCATCGATCCCAAAACGAA	0.527000													7	5					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97185297	97185297	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97185297T>C	ENST00000514100.1	+	4	283	c.41T>C	c.(40-42)cTt>cCt	p.L14P	EPHA6_ENST00000442602.2_Intron|EPHA6_ENST00000389672.5_Intron|EPHA6_ENST00000502694.1_Missense_Mutation_p.L14P	NM_001278300.1	NP_001265229.1	Q9UF33	EPHA6_HUMAN	EPH receptor A6	0						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						ctgtactggcttaatgaaaag	0.428000													12	89					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89854483	89854483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:89854483G>A	ENST00000287908.3	+	2	480	c.87G>A	c.(85-87)agG>agA	p.R29R	STEAP2_ENST00000394621.2_Silent_p.R29R|STEAP2_ENST00000394622.2_Silent_p.R29R|STEAP2_ENST00000394626.1_Silent_p.R29R|STEAP2_ENST00000394632.1_Silent_p.R29R|STEAP2_ENST00000402625.2_Silent_p.R29R|STEAP2_ENST00000394629.2_Silent_p.R29R	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	29					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					AAGATGCAAGGAAGGTCACTG	0.408000													35	125					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133805017	133805017	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133805017C>T	ENST00000372338.4	-	2	731	c.489G>A	c.(487-489)aaG>aaA	p.K163K	FIBCD1_ENST00000253018.4_Silent_p.K5K|FIBCD1_ENST00000448616.1_Silent_p.K163K|FIBCD1_ENST00000372337.2_Silent_p.K5K	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	163					signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		TGCCATGCCCCTTCCGCAGCC	0.701000													5	25					0	0	1	0	0
RNASE10	338879	broad.mit.edu	37	14	20978633	20978633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20978633G>A	ENST00000430083.1	+	2	491	c.87G>A	c.(85-87)atG>atA	p.M29I	RNASE10_ENST00000328444.5_Start_Codon_SNP_p.M1I			Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	1						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	12	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		CAGGCAAAATGAAGCTGAATC	0.488000													37	109					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124731866	124731866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124731866G>A	ENST00000311127.4	-	6	2624	c.2557C>T	c.(2557-2559)Ctt>Ttt	p.L853F		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	853						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						GTGGTCATAAGAGGCTGAGAG	0.517000													29	156					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67053666	67053666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:67053666G>A	ENST00000295568.4	+	3	328	c.197G>A	c.(196-198)cGa>cAa	p.R66Q	KBTBD8_ENST00000417314.2_Missense_Mutation_p.R92Q|KBTBD8_ENST00000460576.1_Intron|KBTBD8_ENST00000469661.1_Intron	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	92	BTB.									breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		AAAGAAGTTCGAATAGTTGGT	0.373000													66	144					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17809054	17809054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17809054G>A	ENST00000378814.5	-	18	2107	c.2108C>T	c.(2107-2109)aCc>aTc	p.T703I	KIF13A_ENST00000378843.2_Missense_Mutation_p.T703I|KIF13A_ENST00000259711.6_Missense_Mutation_p.T703I|KIF13A_ENST00000378816.5_Missense_Mutation_p.T703I|KIF13A_ENST00000378826.2_Missense_Mutation_p.T703I	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	703					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTGGTAATCGGTGAGTTTGCT	0.473000													11	29					0	0	1	0	0
ZNF629	23361	broad.mit.edu	37	16	30794044	30794044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30794044G>A	ENST00000262525.4	-	3	1812	c.1605C>T	c.(1603-1605)atC>atT	p.I535I		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			CCCTCTCATGGATCACCCGGT	0.697000													7	16					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55968569	55968569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55968569G>A	ENST00000263923.4	-	14	2389	c.2094C>T	c.(2092-2094)atC>atT	p.I698I		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	698	Ig-like C2-type 7.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TAAACCACATGATCTGTGGAG	0.458000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			51	85					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1585101	1585101	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1585101G>A	ENST00000381297.4	-	2	561	c.351C>T	c.(349-351)atC>atT	p.I117I		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	117						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCTCCACGCTGATACAGGTCA	0.632000			T	CRLF2	"""B-ALL, Downs associated ALL"""								6	18					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100451918	100451918	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100451918A>T	ENST00000279907.7	-	14	3349	c.3137T>A	c.(3136-3138)aTc>aAc	p.I1046N	UHRF1BP1L_ENST00000545232.2_Missense_Mutation_p.I696N	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1046										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						AGCTTTAAAGATGGACTCTAT	0.358000													30	81					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49831551	49831551	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49831551G>A	ENST00000527477.1	+	0	1776																											CAATATATATGGAGAGGAGGG	0.453000													24	28					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187447255	187447255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:187447255G>A	ENST00000406870.2	-	5	1304	c.938C>T	c.(937-939)gCc>gTc	p.A313V	BCL6_ENST00000232014.4_Missense_Mutation_p.A313V|RP11-211G3.3_ENST00000449623.1_Intron|BCL6_ENST00000450123.2_Missense_Mutation_p.A313V|RP11-211G3.3_ENST00000437407.1_Intron	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	313					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GAAATGCAGGGCAATCTCATC	0.592000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								44	104					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904976	73904976	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73904976G>T	ENST00000342056.2	+	15	3093	c.2695G>T	c.(2695-2697)Gag>Tag	p.E899*	KCNQ5_ENST00000414165.2_Nonsense_Mutation_p.E770*|KCNQ5_ENST00000403813.2_Nonsense_Mutation_p.E871*|KCNQ5_ENST00000402622.2_Nonsense_Mutation_p.E890*|KCNQ5_ENST00000370398.1_Nonsense_Mutation_p.E880*|KCNQ5_ENST00000355635.3_Nonsense_Mutation_p.E881*|KCNQ5_ENST00000355194.4_Nonsense_Mutation_p.E880*	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	880					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GGGTCCCGAAGAGACAGAGAC	0.507000													8	132					0.000274275	0.000274652	1	1	0
CCDC136	64753	broad.mit.edu	37	7	128445896	128445896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128445896G>A	ENST00000297788.4	+	7	1397	c.1030G>A	c.(1030-1032)Gag>Aag	p.E344K	CCDC136_ENST00000378685.4_Missense_Mutation_p.E382K|CCDC136_ENST00000487361.1_Missense_Mutation_p.E344K|CCDC136_ENST00000464832.1_Missense_Mutation_p.E394K	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	344						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GCTGCAGAGGGAGCTCAAGTG	0.562000													15	28					0	0	1	0	0
TRAF1	7185	broad.mit.edu	37	9	123671621	123671621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123671621G>A	ENST00000373887.3	-	7	3364	c.919C>T	c.(919-921)Ctg>Ttg	p.L307L	TRAF1_ENST00000546084.1_Silent_p.L185L|TRAF1_ENST00000540010.1_Silent_p.L307L	NM_005658.4	NP_005649.1	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	307	MATH.				apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(4)|pancreas(1)|skin(2)	22						TACAGCCGCAGGCACAACTTG	0.547000													26	198					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	56989552	56989552	+	Splice_Site	SNP	C	C	T	rs1802023		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:56989552C>T	ENST00000371250.3	-	4	1127	c.575_splice	c.e4-1	p.R192_splice		NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	192					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						AGAAGGACTTCCTGCAAGAGC	0.502000													10	22					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230916267	230916267	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230916267C>T	ENST00000354537.1	+	10	1298	c.1216C>T	c.(1216-1218)Ctg>Ttg	p.L406L	CAPN9_ENST00000366666.2_Silent_p.L369L|CAPN9_ENST00000271971.2_Silent_p.L432L|RP11-99J16__A.2_ENST00000452640.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA|RP11-99J16__A.2_ENST00000428480.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	432	Domain III.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				AGACGAACACCTGAACAAAGA	0.522000													36	99					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130292832	130292832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130292832C>T	ENST00000358511.6	+	7	3041	c.3010C>T	c.(3010-3012)Ctt>Ttt	p.L1004F	COL6A6_ENST00000453409.2_Missense_Mutation_p.L1004F	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1004	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCTTGTTTTCCTTATGGATGG	0.363000													11	33					0	0	1	0	0
TRBV7-3	28595	broad.mit.edu	37	7	142247209	142247209	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142247209G>A	ENST00000390361.3	-	0	296																											GCAAAGAACCGATCGTTGGGC	0.572000													38	99					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59166535	59166535	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59166535G>A	ENST00000262717.4	+	3	761	c.363G>A	c.(361-363)agG>agA	p.R121R	CDH20_ENST00000536675.2_Silent_p.R121R|CDH20_ENST00000538374.1_Silent_p.R121R			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	121	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				CCATTCAGAGGCTCGACCGAG	0.552000													13	20					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194117702	194117702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:194117702C>T	ENST00000401815.1	-	1	1381	c.1310G>A	c.(1309-1311)cGg>cAg	p.R437Q	GP5_ENST00000323007.3_Missense_Mutation_p.R437Q			P40197	GPV_HUMAN	glycoprotein V (platelet)	437	LRRCT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		TAGGTGCTGCCGCAGCCACCC	0.756000													7	1					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43625191	43625191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43625191G>A	ENST00000405006.4	-	29	4497	c.4146C>T	c.(4144-4146)acC>acT	p.T1382T	THADA_ENST00000405975.2_Silent_p.T1382T|THADA_ENST00000330266.7_Intron|THADA_ENST00000485353.1_5'UTR|THADA_ENST00000415080.2_Silent_p.T1063T	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1382							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GAGTTCGAATGGTATTAGGAA	0.483000													50	72					0	0	1	0	0
TYR	7299	broad.mit.edu	37	11	89028445	89028445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:89028445C>T	ENST00000263321.5	+	5	2003	c.1501C>T	c.(1501-1503)Cgt>Tgt	p.R501C		NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	501					eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	CTTGCTGTGTCGTCACAAGAG	0.537000													19	46					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174326	150174326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150174326G>A	ENST00000307271.3	+	5	2030	c.1456G>A	c.(1456-1458)Gga>Aga	p.G486R		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	486						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding	p.G486R(1)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GACATGGGACGGACAGGAGGT	0.597000													24	37					0	0	1	0	0
IL1RN	3557	broad.mit.edu	37	2	113890437	113890437	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113890437G>A	ENST00000361779.3	+	6	766	c.421G>A	c.(421-423)Gag>Aag	p.E141K	IL1RN_ENST00000409930.3_Missense_Mutation_p.E175K|IL1RN_ENST00000409052.1_Missense_Mutation_p.E141K|IL1RN_ENST00000354115.2_Missense_Mutation_p.E157K|IL1RN_ENST00000259206.5_Missense_Mutation_p.E178K	NM_173843.2	NP_776215.1	P18510	IL1RA_HUMAN	interleukin 1 receptor antagonist	175					immune response|inflammatory response|response to glucocorticoid stimulus	centrosome|extracellular space|nucleus|plasma membrane	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	10					Anakinra(DB00026)	CTACTTCCAGGAGGACGAGTA	0.612000									Lichen Sclerosis et Atrophicus, Familial Clustering of				11	99					0	0	1	0	0
SNRPB	6628	broad.mit.edu	37	20	2443865	2443865	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2443865G>A	ENST00000339610.6	-	6	647	c.192C>T	c.(190-192)acC>acT	p.T64T	SNRPB_ENST00000381342.2_Silent_p.T143T|SNRPB_ENST00000438552.2_Silent_p.T143T			P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	143					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						TTCCTTGTGGGGTCATCACCT	0.562000													15	41					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57317578	57317578	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57317578A>T	ENST00000457912.1	+	8	1532	c.1532A>T	c.(1531-1533)aAg>aTg	p.K511M	SMTNL1_ENST00000527972.1_Missense_Mutation_p.K493M|SMTNL1_ENST00000399154.2_Missense_Mutation_p.K456M			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	493										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						AAGACCAAGAAGAAGTGAGGA	0.602000													8	16					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215301468	215301468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215301468C>T	ENST00000312504.5	+	3	1308	c.506C>T	c.(505-507)cCt>cTt	p.P169L	AC107218.3_ENST00000437883.1_RNA|VWC2L_ENST00000427124.1_Intron|AC107218.3_ENST00000412896.1_RNA	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	169	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						CAATGTTGTCCTGTCTGCAAA	0.453000													14	31					0	0	1	0	0
SART3	9733	broad.mit.edu	37	12	108919967	108919967	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108919967A>G	ENST00000228284.3	-	16	2513	c.2279T>C	c.(2278-2280)cTt>cCt	p.L760P	SART3_ENST00000431469.2_Missense_Mutation_p.L724P	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	760	RRM 1.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						CAGTGCCTGAAGGGCTGATTT	0.507000									Porokeratosis				16	139					0	0	1	0	0
RBBP8NL	140893	broad.mit.edu	37	20	60987918	60987918	+	Missense_Mutation	SNP	C	C	T	rs145375194	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60987918C>T	ENST00000252998.1	-	12	1870	c.1714G>A	c.(1714-1716)Gaa>Aaa	p.E572K		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		TCATCCAGTTCGTCGGACTCT	0.652000													29	74					0	0	1	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208773295	208773295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:208773295G>A	ENST00000457206.1	-	7	2364	c.1937C>T	c.(1936-1938)tCc>tTc	p.S646F	PLEKHM3_ENST00000389247.4_Silent_p.F631F|PLEKHM3_ENST00000427836.2_Silent_p.F631F			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	0					intracellular signal transduction		metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATTCTCTGGGGAAAATTCTGA	0.438000													24	62					0	0	1	0	0
KRT222	125113	broad.mit.edu	37	17	38818217	38818217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38818217C>T	ENST00000476049.1	-	2	217	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	KRT222_ENST00000394052.3_Missense_Mutation_p.R59Q			Q8N1A0	KT222_HUMAN	keratin 222	59						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(2)|skin(1)	15						CCACTGGCGTCGGGCCTCCTT	0.468000													92	116					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16878310	16878310	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:16878310C>T	ENST00000377833.4	-	63	10169	c.10104G>A	c.(10102-10104)atG>atA	p.M3368I		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3368	CUB 25.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTGCAGTACTCATAGAAGAAT	0.403000													35	67					0	0	1	0	0
GNA15	2769	broad.mit.edu	37	19	3151807	3151807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3151807C>T	ENST00000262958.3	+	4	846	c.588C>T	c.(586-588)tgC>tgT	p.C196C	AC005264.2_ENST00000587587.1_RNA	NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	196					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		ACGAGTACTGCTTCTCCGTGC	0.647000													9	110					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45706897	45706897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45706897C>T	ENST00000291582.5	+	3	471	c.344C>T	c.(343-345)cCc>cTc	p.P115L		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	115					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		GGGAGGAAGCCCCCGGCCGTC	0.677000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				23	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179528772	179528772	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179528772G>A	ENST00000589042.1	-	169	36558	c.36334C>T	c.(36334-36336)Cct>Tct	p.P12112S	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10261	Ig-like 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTTTTTAGGAGGCACCACC	0.388000													45	96					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47264840	47264840	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47264840C>T	ENST00000271153.4	+	1	123	c.87C>T	c.(85-87)ctC>ctT	p.L29L	CYP4B1_ENST00000371919.4_Silent_p.L29L|CYP4B1_ENST00000371923.4_Silent_p.L29L|CYP4B1_ENST00000546128.1_Intron			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	29					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TTCTCAAGCTCATCCACCTGC	0.577000													8	18					0	0	1	0	0
CELF5	60680	broad.mit.edu	37	19	3284932	3284932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3284932C>T	ENST00000541430.2	+	9	1033	c.997C>T	c.(997-999)Cct>Tct	p.P333S	CELF5_ENST00000292672.2_Missense_Mutation_p.P358S|CELF5_ENST00000588101.1_3'UTR	NM_001172673.1	NP_001166144.1	Q8N6W0	CELF5_HUMAN	CUGBP, Elav-like family member 5	358					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)	13						GACACTGCATCCTGCCTTCTC	0.711000													3	21					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12760765	12760765	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12760765G>A	ENST00000456935.2	-	18	2269	c.2229C>T	c.(2227-2229)ttC>ttT	p.F743F	MAN2B1_ENST00000221363.4_Silent_p.F742F	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	743					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TGTCTGTGTAGAAGCGTCCCT	0.607000													65	156					0	0	1	0	0
E2F7	144455	broad.mit.edu	37	12	77419463	77419463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:77419463G>A	ENST00000322886.7	-	12	2675	c.2440C>T	c.(2440-2442)Cct>Tct	p.P814S	E2F7_ENST00000416496.2_Intron	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	814					cell cycle	transcription factor complex	DNA binding|identical protein binding	p.P814S(2)		central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						TGAAGCTGAGGGTCTGCAGAA	0.537000													37	61					0	0	1	0	0
PLEKHN1	84069	broad.mit.edu	37	1	907761	907761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:907761G>A	ENST00000379409.2	+	9	1145	c.1115G>A	c.(1114-1116)gGg>gAg	p.G372E	PLEKHN1_ENST00000379407.2_Missense_Mutation_p.G332E|PLEKHN1_ENST00000379410.3_Missense_Mutation_p.G320E			Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N member 1	372										central_nervous_system(1)|endometrium(3)|kidney(1)|lung(2)|skin(1)|urinary_tract(1)	9	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CACAGGGAGGGGGCCCCGCCG	0.672000													7	3					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68649559	68649559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68649559C>T	ENST00000423218.2	-	7	774	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	ITGA11_ENST00000562826.1_5'UTR|ITGA11_ENST00000315757.7_Missense_Mutation_p.E227K			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	227	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	CTGGCAGCTTCCACCACATCT	0.468000													39	46					0	0	1	0	0
FGF5	2250	broad.mit.edu	37	4	81207505	81207505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:81207505C>T	ENST00000312465.7	+	3	712	c.486C>T	c.(484-486)ttC>ttT	p.F162F	FGF5_ENST00000456523.3_3'UTR|FGF5_ENST00000503413.1_3'UTR	NM_004464.3	NP_004455.2	P12034	FGF5_HUMAN	fibroblast growth factor 5	162					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22						ACTGCAAGTTCAGGGAGCGTT	0.393000													34	183					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94718186	94718186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94718186C>T	ENST00000304338.3	+	16	1972	c.1818C>T	c.(1816-1818)ttC>ttT	p.F606F		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	606						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GTAAATATTTCTTTCTACCTG	0.289000													24	53					0	0	1	0	0
C7orf34	135927	broad.mit.edu	37	7	142636722	142636722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142636722C>T	ENST00000409607.3	+	1	120	c.79C>T	c.(79-81)Cct>Tct	p.P27S		NM_178829.4	NP_849151.2	Q96L11	CG034_HUMAN	chromosome 7 open reading frame 34	2						extracellular region				large_intestine(1)|lung(4)	5	Melanoma(164;0.059)					CAGGTCCATGCCTCCCCTGGC	0.657000													13	51					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103444967	103444967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103444967G>A	ENST00000358392.2	-	32	2934	c.2617C>T	c.(2617-2619)Cca>Tca	p.P873S	COL11A1_ENST00000370096.3_Missense_Mutation_p.P861S|COL11A1_ENST00000512756.1_Missense_Mutation_p.P745S|COL11A1_ENST00000353414.4_Missense_Mutation_p.P822S	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	861	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGGCACCTGGAAACCCAGGG	0.353000													17	37					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100169943	100169943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100169943C>T	ENST00000524871.1	+	20	2725	c.2435C>T	c.(2434-2436)gCt>gTt	p.A812V	CNTN5_ENST00000279463.3_Missense_Mutation_p.A812V|CNTN5_ENST00000528682.1_Missense_Mutation_p.A812V|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Missense_Mutation_p.A812V|CNTN5_ENST00000418526.2_Missense_Mutation_p.A738V	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	812	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TATATTGTGGCTTTCAGACCC	0.378000													12	31					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	21556024	21556024	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:21556024G>A	ENST00000298925.5	+	17	1987	c.1834G>A	c.(1834-1836)Gat>Aat	p.D612N	NELL1_ENST00000529218.1_3'UTR|NELL1_ENST00000325319.5_Missense_Mutation_p.D527N|NELL1_ENST00000532434.1_Intron|NELL1_ENST00000357134.5_Missense_Mutation_p.D584N			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	584	EGF-like 6; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity	p.D584N(1)		NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						TTTCCATGACGATGGGACCTA	0.532000													6	76					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46307639	46307639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46307639C>T	ENST00000357422.2	+	4	1533	c.990C>T	c.(988-990)ttC>ttT	p.F330F	CCR3_ENST00000541018.1_Silent_p.F330F|CCR3_ENST00000395940.2_Silent_p.F330F|CCR3_ENST00000545097.1_Silent_p.F351F|CCR3_ENST00000395942.2_Silent_p.F330F			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	330					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		ACATCCCATTCCTTCCTAGTG	0.512000													7	60					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468954	56468954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:56468954C>T	ENST00000288221.6	-	2	337	c.82G>A	c.(82-84)Ggc>Agc	p.G28S		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	28						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CTTCGGTGGCCCAAACGAGGA	0.498000													20	57					0	0	1	0	0
GGA2	23062	broad.mit.edu	37	16	23492068	23492068	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23492068G>A	ENST00000309859.4	-	10	986	c.904C>T	c.(904-906)Ctc>Ttc	p.L302F	GGA2_ENST00000567468.1_Intron	NM_015044.4	NP_055859.1	Q9UJY4	GGA2_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	302	GAT.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(48;0.0386)		TGGGTGAGGAGGTCATTTGCC	0.498000													28	56					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	92027138	92027138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92027138C>T	ENST00000265742.3	+	19	2873	c.2497C>T	c.(2497-2499)Cct>Tct	p.P833S		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	833							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGACTACACCCCTGCCAGTCG	0.542000													67	186					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141660725	141660725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141660725G>A	ENST00000389484.3	-	23	4501	c.3530C>T	c.(3529-3531)tCg>tTg	p.S1177L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1177					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTGTTCAGCGAACACTCATC	0.393000										TSP Lung(27;0.18)			28	51					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156828383	156828383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156828383C>T	ENST00000368195.3	-	1	427	c.31G>A	c.(31-33)Gca>Aca	p.A11T	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	11					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGCAGGCATGCTCCCCAGGGC	0.617000													30	80					0	0	1	0	0
TPCN2	219931	broad.mit.edu	37	11	68839451	68839451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68839451C>T	ENST00000294309.3	+	11	1122	c.1021C>T	c.(1021-1023)Cta>Tta	p.L341L	TPCN2_ENST00000442692.2_3'UTR|TPCN2_ENST00000542467.1_Silent_p.L341L	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	341					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTTTGAAGTCCTATCCTCCAT	0.627000													27	94					0	0	1	0	0
SRL	6345	broad.mit.edu	37	16	4247875	4247875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4247875G>A	ENST00000399609.3	-	4	313	c.301C>T	c.(301-303)Ccg>Tcg	p.P101S	SRL_ENST00000537996.1_Missense_Mutation_p.P59S	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	560	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						ACACTCCACGGTCCCAGGAAC	0.423000													27	45					0	0	1	0	0
IP6K3	117283	broad.mit.edu	37	6	33695869	33695869	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33695869C>T	ENST00000451316.1	-	4	943	c.408G>A	c.(406-408)aaG>aaA	p.K136K	IP6K3_ENST00000293756.4_Silent_p.K136K	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	136					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						CTCACCTCTCCTTGGGTGAGC	0.652000													11	27					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140396114	140396114	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140396114C>T	ENST00000406427.1	-	15	1875	c.1539G>A	c.(1537-1539)agG>agA	p.R513R	PNPLA7_ENST00000371457.1_Silent_p.R94R|PNPLA7_ENST00000277531.4_Silent_p.R488R	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	488					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GGTCTCCCTGCCTTGACACCA	0.637000													4	29					0	0	1	0	0
OR2W5	441932	broad.mit.edu	37	1	247654918	247654918	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247654918G>A	ENST00000522351.1	+	0	549							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GTCCTCAGACGATGCAGCTCT	0.557000													31	61					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85906067	85906067	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:85906067G>A	ENST00000373131.1	+	3	793	c.630G>A	c.(628-630)gcG>gcA	p.A210A	DACH2_ENST00000508860.1_Silent_p.A56A|DACH2_ENST00000510272.1_Silent_p.A4A|DACH2_ENST00000373125.4_Silent_p.A223A	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TGGCTGAGGCGATGAAACTTC	0.358000													16	5					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919910	4919910	+	Missense_Mutation	SNP	C	C	T	rs149897413		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4919910C>T	ENST00000433855.1	+	1	1569	c.703C>T	c.(703-705)Cat>Tat	p.H235Y	KCNA6_ENST00000280684.3_Missense_Mutation_p.H235Y	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	235						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.H235Y(1)		NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CTACACATTTCATCATGGCAT	0.552000										HNSCC(72;0.22)			28	118					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58118073	58118073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58118073C>T	ENST00000332854.6	+	3	1400	c.1180C>T	c.(1180-1182)Ctt>Ttt	p.L394F	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CAATATCTACCTTATTCACCA	0.423000													46	98					0	0	1	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198523	91198523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:91198523G>A	ENST00000341233.4	-	6	1166	c.776C>T	c.(775-777)tCc>tTc	p.S259F	SLC16A12_ENST00000371790.4_Missense_Mutation_p.S289F	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	259						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						AAACAGAACGGAGACGGCTAA	0.448000													25	55					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280073	152280073	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152280073C>T	ENST00000368799.1	-	3	7324	c.7289G>A	c.(7288-7290)cGg>cAg	p.R2430Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2430	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGTCCCGGTCCGTCCATGGGC	0.587000									Ichthyosis				95	363					0	0	1	0	0
SEPT9	10801	broad.mit.edu	37	17	75398191	75398191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:75398191C>T	ENST00000329047.8	+	2	885	c.73C>T	c.(73-75)Cca>Tca	p.P25S	SEPT9_ENST00000590294.1_Missense_Mutation_p.P25S|SEPT9_ENST00000449803.2_5'UTR|SEPT9_ENST00000427177.1_Missense_Mutation_p.P43S|SEPT9_ENST00000591198.1_Missense_Mutation_p.P24S|SEPT9_ENST00000592420.1_5'UTR|SEPT9_ENST00000423034.2_Missense_Mutation_p.P36S|SEPT9_ENST00000431235.2_5'UTR|SEPT9_ENST00000588690.1_5'UTR|SEPT9_ENST00000427674.2_5'UTR	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	43					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			CAACTCCACCCCACCCCGGAG	0.567000													19	49					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769386	247769386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247769386C>T	ENST00000320002.2	+	1	531	c.499C>T	c.(499-501)Cct>Tct	p.P167S	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTTGCAATTGCCTCTCTGTGG	0.473000													37	80					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61568368	61568368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61568368C>T	ENST00000577647.1	+	7	1018	c.973C>T	c.(973-975)Cct>Tct	p.P325S	ACE_ENST00000413513.3_Missense_Mutation_p.P325S|ACE_ENST00000290866.4_Missense_Mutation_p.P899S|ACE_ENST00000428043.1_Missense_Mutation_p.P899S|ACE_ENST00000490216.2_Missense_Mutation_p.P325S|ACE_ENST00000290863.6_Missense_Mutation_p.P325S|ACE_ENST00000421982.2_Missense_Mutation_p.P145S			P12821	ACE_HUMAN	angiotensin I converting enzyme	899	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGTGCCCTTCCCTTCAGCCCC	0.617000													42	127					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46306935	46306935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46306935G>A	ENST00000357422.2	+	4	829	c.286G>A	c.(286-288)Ggg>Agg	p.G96R	CCR3_ENST00000541018.1_Missense_Mutation_p.G96R|CCR3_ENST00000395940.2_Missense_Mutation_p.G96R|CCR3_ENST00000545097.1_Missense_Mutation_p.G117R|CCR3_ENST00000395942.2_Missense_Mutation_p.G96R			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	96					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CTATGTCAGGGGGCATAACTG	0.493000													87	217					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25430789	25430789	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25430789G>A	ENST00000424208.1	+	0	582				SNORD115-9_ENST00000362912.1_RNA	NR_003305.1																						GGTCGATGATGAGAACCTTAT	0.493000													89	223					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78647111	78647111	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:78647111G>A	ENST00000286627.5	-	27	4402	c.3450C>T	c.(3448-3450)tcC>tcT	p.S1150S	KCNMA1_ENST00000404857.1_Silent_p.S1191S|KCNMA1_ENST00000372443.1_Silent_p.S1177S|KCNMA1_ENST00000286628.8_Silent_p.S1208S|KCNMA1_ENST00000372440.1_Silent_p.S1150S|KCNMA1_ENST00000354353.5_Silent_p.S1211S|KCNMA1_ENST00000406533.3_Silent_p.S1212S|KCNMA1_ENST00000404771.3_Silent_p.S1208S	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	1208					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGGATGGGATGGAGTGAACAG	0.572000													25	131					0	0	1	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47650692	47650692	+	Missense_Mutation	SNP	G	G	A	rs150391778		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47650692G>A	ENST00000294338.2	-	3	376	c.254C>T	c.(253-255)tCg>tTg	p.S85L	PDZK1IP1_ENST00000371885.1_Missense_Mutation_p.S85L|PDZK1IP1_ENST00000491793.1_5'UTR	NM_005764.3	NP_005755.1	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	85						integral to membrane				endometrium(1)|lung(1)|prostate(1)	3						GGCCGCCATCGAAGAGTACCT	0.602000													22	57					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833573	168833573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168833573G>A	ENST00000464456.1	-	7	2723	c.1523C>T	c.(1522-1524)cCc>cTc	p.P508L	MECOM_ENST00000433243.2_Missense_Mutation_p.P509L|MECOM_ENST00000460814.1_Missense_Mutation_p.P508L|MECOM_ENST00000392736.3_Missense_Mutation_p.P508L|MECOM_ENST00000472280.1_Missense_Mutation_p.P509L|MECOM_ENST00000264674.3_Missense_Mutation_p.P573L|MECOM_ENST00000468789.1_Missense_Mutation_p.P508L|MECOM_ENST00000494292.1_Missense_Mutation_p.P696L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						AAATGGGAGGGGAAACATGGA	0.423000													21	102					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32724803	32724803	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:32724803C>T	ENST00000421745.2	+	46	8792	c.8658C>T	c.(8656-8658)tcC>tcT	p.S2886S		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2886					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CAGATAGCTCCGTGGGTGCTC	0.438000													68	199					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71891540	71891540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71891540C>T	ENST00000258104.3	+	45	5306	c.5029C>T	c.(5029-5031)Cgc>Tgc	p.R1677C	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Missense_Mutation_p.R1678C|DYSF_ENST00000409744.1_Missense_Mutation_p.R1685C|DYSF_ENST00000410020.3_Missense_Mutation_p.R1716C|DYSF_ENST00000413539.2_Missense_Mutation_p.R1708C|DYSF_ENST00000429174.2_Missense_Mutation_p.R1698C|DYSF_ENST00000409366.1_Missense_Mutation_p.R1699C|DYSF_ENST00000409582.3_Missense_Mutation_p.R1715C|DYSF_ENST00000409762.1_Missense_Mutation_p.R1694C|DYSF_ENST00000409651.1_Missense_Mutation_p.R1709C|DYSF_ENST00000410041.1_Missense_Mutation_p.R1695C	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1677						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GTTTGGGGCTCGCTGTGGACT	0.552000													22	45					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149509363	149509363	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149509363G>A	ENST00000378016.2	+	0	9761							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGAGCTGGGGGATGGGGTCCA	0.701000													4	22					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891498	5891498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:5891498C>T	ENST00000581347.1	-	3	1210	c.565G>A	c.(565-567)Gag>Aag	p.E189K	TMEM200C_ENST00000383490.2_Missense_Mutation_p.E189K|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	189						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						TCCCGGTTCTCGTGGAGGACC	0.602000													7	14					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45396248	45396248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45396248G>A	ENST00000389039.6	-	20	2949	c.2564C>T	c.(2563-2565)tCc>tTc	p.S855F	DUOX2_ENST00000603300.1_Missense_Mutation_p.S855F			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	855	EF-hand 2.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ATCCTCTGGGGAGCCTGGGAA	0.512000													12	33					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100585734	100585734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100585734C>T	ENST00000471714.1	-	10	1107	c.998G>A	c.(997-999)cGa>cAa	p.R333Q	ABI3BP_ENST00000495063.1_Missense_Mutation_p.R333Q|ABI3BP_ENST00000284322.5_Missense_Mutation_p.R333Q			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	333						extracellular space		p.R333Q(2)		central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TGTTGTGGGTCGTGCTGAGAT	0.358000													16	40					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55139809	55139809	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55139809C>T	ENST00000257290.5	+	10	1801	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	490	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTGTGACTTTCGCCAAAGTGG	0.532000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			6	105					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140846790	140846790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140846790C>T	ENST00000371372.1	+	7	1176	c.1031C>T	c.(1030-1032)tCc>tTc	p.S344F	CACNA1B_ENST00000277551.2_Missense_Mutation_p.S344F|CACNA1B_ENST00000371363.1_Missense_Mutation_p.S344F|CACNA1B_ENST00000371355.4_Missense_Mutation_p.S344F|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371357.1_Missense_Mutation_p.S344F	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	344					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	ATCATCGGCTCCTTCTTCATG	0.582000													7	60					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5436224	5436224	+	Missense_Mutation	SNP	G	G	A	rs149973177		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:5436224G>A	ENST00000345221.3	-	11	3768	c.3214C>T	c.(3214-3216)Cct>Tct	p.P1072S	NLRP1_ENST00000354411.3_Missense_Mutation_p.P1042S|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000262467.5_Missense_Mutation_p.P1076S|NLRP1_ENST00000577119.1_Missense_Mutation_p.P1042S|NLRP1_ENST00000572272.1_Missense_Mutation_p.P1072S|NLRP1_ENST00000269280.4_Missense_Mutation_p.P1072S	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	1072					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding	p.P1072S(2)|p.P1076S(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GTCCCCAAAGGCTTCGTATGC	0.577000													7	49					0	0	1	0	0
BHMT	635	broad.mit.edu	37	5	78411722	78411722	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78411722G>A	ENST00000274353.5	+	2	273	c.166_splice	c.e2+1	p.V56_splice	DMGDH_ENST00000520388.1_Intron|BHMT_ENST00000524080.1_Splice_Site_p.G56_splice	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	56	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	CCCAGAAGCAGGTTGGTGCAG	0.547000													11	54					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23428365	23428365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23428365G>A	ENST00000307149.5	-	9	1400	c.1215C>T	c.(1213-1215)gcC>gcT	p.A405A		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	405					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		ATCTGTCAACGGCTGCAGACG	0.562000													13	50					0	0	1	0	0
TSPAN9	10867	broad.mit.edu	37	12	3387589	3387589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:3387589C>T	ENST00000011898.5	+	4	227	c.66C>T	c.(64-66)ctC>ctT	p.L22L	TSPAN9_ENST00000407263.1_Silent_p.L22L|TSPAN9_ENST00000537971.1_Silent_p.L22L|TSPAN9_ENST00000492305.1_3'UTR	NM_006675.4	NP_006666.1	O75954	TSN9_HUMAN	tetraspanin 9	22						integral to plasma membrane|membrane fraction				endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			CTTTCCAGCTCTGTGGCTGTG	0.602000													42	116					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50204093	50204093	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50204093C>T	ENST00000392518.4	+	5	806	c.434C>T	c.(433-435)tCc>tTc	p.S145F	CPT1C_ENST00000323446.5_Missense_Mutation_p.S145F|CPT1C_ENST00000598293.1_Missense_Mutation_p.S145F|CPT1C_ENST00000354199.5_Missense_Mutation_p.S145F|CPT1C_ENST00000405931.2_Missense_Mutation_p.S145F	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	145					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GCCATGTCCTCCCCCACCAAG	0.622000													40	109					0	0	1	0	0
SLC22A15	55356	broad.mit.edu	37	1	116569584	116569584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:116569584C>T	ENST00000369503.4	+	5	799	c.669C>T	c.(667-669)tcC>tcT	p.S223S	SLC22A15_ENST00000369502.1_Silent_p.S223S	NM_018420.2	NP_060890.2	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	223					ion transport	integral to membrane	transmembrane transporter activity			endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|urinary_tract(1)	17	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TCATCCGCTCCTGGAGGACCC	0.448000													60	123					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021043	132021043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132021043G>A	ENST00000356920.5	+	15	2109	c.2015G>A	c.(2014-2016)aGa>aAa	p.R672K	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	672							ATP binding										AGCCAGCTAAGAGAAAAGAAA	0.363000													6	45					0	0	1	0	0
RHOF	54509	broad.mit.edu	37	12	122218831	122218831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122218831C>T	ENST00000267205.2	-	4	1046	c.418G>A	c.(418-420)Gag>Aag	p.E140K	TMEM120B_ENST00000538055.1_Intron|TMEM120B_ENST00000449592.2_3'UTR	NM_019034.2	NP_061907.2	Q9HBH0	RHOF_HUMAN	ras homolog family member F (in filopodia)	140					actin filament organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity			large_intestine(1)|lung(1)|ovary(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;4.38e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.223)		CGCAGCTGCTCCTTGTCCTTC	0.662000													11	25					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48139140	48139140	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48139140G>A	ENST00000311303.3	-	19	2928	c.2583C>T	c.(2581-2583)ttC>ttT	p.F861F	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_Silent_p.F858F	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	861	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				ACACCAGCATGAACACCATGC	0.572000													27	58					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121430236	121430236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121430236C>T	ENST00000260197.7	+	21	3048	c.2919C>T	c.(2917-2919)atC>atT	p.I973I		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	973					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGAATGAAATCTACTGGGATG	0.478000													25	81					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70917961	70917961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70917961G>A	ENST00000264436.3	-	8	1250	c.806C>T	c.(805-807)gCc>gTc	p.A269V	ADD2_ENST00000407644.2_Missense_Mutation_p.A269V|ADD2_ENST00000430656.1_Missense_Mutation_p.A285V|ADD2_ENST00000355733.3_Missense_Mutation_p.A269V|AC007395.3_ENST00000457851.1_RNA|ADD2_ENST00000413157.2_Missense_Mutation_p.A269V	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	269					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						GATCCGATCGGCTTCCTGCTC	0.537000													24	80					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23542422	23542422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23542422G>A	ENST00000300619.7	-	4	3564	c.3359C>T	c.(3358-3360)gCt>gTt	p.A1120V	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.A1088V	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1120						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTTAGTAAGAGCTGAGGACTC	0.398000													15	93					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033513	82033513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82033513C>T	ENST00000328945.5	-	3	512	c.385G>A	c.(385-387)Gga>Aga	p.G129R	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	129					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						ACTTGACCTCCAAAGATGACA	0.488000													12	91					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176707784	176707784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176707784C>T	ENST00000439151.2	+	18	5886	c.5841C>T	c.(5839-5841)ttC>ttT	p.F1947F	NSD1_ENST00000361032.4_Silent_p.F1844F|NSD1_ENST00000354179.4_Silent_p.F1678F|NSD1_ENST00000347982.4_Silent_p.F1678F	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1947	SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTGAAATTTTCCGCACATTAC	0.463000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			27	54					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89388756	89388756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89388756C>T	ENST00000439576.2	+	7	1446	c.1072C>T	c.(1072-1074)Cca>Tca	p.P358S	ACAN_ENST00000558207.1_Missense_Mutation_p.P358S|ACAN_ENST00000559004.1_Missense_Mutation_p.P358S|ACAN_ENST00000561243.1_Missense_Mutation_p.P358S|ACAN_ENST00000352105.7_Missense_Mutation_p.P358S	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	358					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGTGGACATCCCAGAAAACTT	0.577000													29	44					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100129237	100129237	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100129237C>T	ENST00000330710.5	+	6	1625	c.1527C>T	c.(1525-1527)aaC>aaT	p.N509N	HHIPL1_ENST00000357223.2_Silent_p.N509N	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	509					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				TCCAAGAGAACCCAGGGACAG	0.572000													8	51					0	0	1	0	0
GPR6	2830	broad.mit.edu	37	6	110300424	110300424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110300424G>A	ENST00000414000.2	+	3	393	c.154G>A	c.(154-156)Gga>Aga	p.G52R	GPR6_ENST00000275169.3_Missense_Mutation_p.G37R			P46095	GPR6_HUMAN	G protein-coupled receptor 6	37						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GGGCGAATGGGGACCCCCTGC	0.736000													16	29					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139657563	139657563	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139657563G>A	ENST00000263552.6	+	12	1360	c.822_splice	c.e12+1	p.E274_splice	TBXAS1_ENST00000425687.1_Splice_Site_p.E206_splice|TBXAS1_ENST00000416849.2_Splice_Site_p.E320_splice|TBXAS1_ENST00000411653.1_Splice_Site_p.E273_splice|TBXAS1_ENST00000414508.2_Splice_Site_p.E274_splice|TBXAS1_ENST00000458722.1_Splice_Site_p.E319_splice|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000336425.5_Splice_Site_p.E273_splice|TBXAS1_ENST00000436047.2_Splice_Site_p.E274_splice|TBXAS1_ENST00000448866.1_Splice_Site_p.E273_splice	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	273					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					CTGCCGAAGAGGTAACGTATT	0.478000													6	58					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675180	81675180	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81675180C>T	ENST00000550584.2	-	26	3363	c.3068G>A	c.(3067-3069)tGg>tAg	p.W1023*	PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.W1008*|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.W1008*|PPFIA2_ENST00000541570.2_Nonsense_Mutation_p.W559*|PPFIA2_ENST00000541017.1_Nonsense_Mutation_p.W209*|RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.W1002*|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.W1017*|PPFIA2_ENST00000407050.4_Nonsense_Mutation_p.W922*|PPFIA2_ENST00000550359.2_Nonsense_Mutation_p.W870*|PPFIA2_ENST00000443686.3_Nonsense_Mutation_p.W918*|PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.W1023*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	922										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ATTTCCAATCCACTCATGATT	0.388000													27	88					0	0	1	0	0
TRIP13	9319	broad.mit.edu	37	5	893150	893150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:893150C>T	ENST00000166345.3	+	1	393	c.37C>T	c.(37-39)Ccc>Tcc	p.P13S		NM_004237.3	NP_004228.1	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	13					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	18			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			GCAGGCGCTTCCCTGTGTGGC	0.726000													6	8					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6730183	6730183	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6730183G>A	ENST00000329858.4	-	2	988	c.232C>T	c.(232-234)Cgt>Tgt	p.R78C	LPAR5_ENST00000431922.1_Missense_Mutation_p.R78C|LPAR5_ENST00000540335.1_5'UTR	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	78						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						TAGGAGAGACGAACGGGCAGC	0.632000													8	20					0	0	1	0	0
MRPL1	65008	broad.mit.edu	37	4	78873665	78873665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:78873665C>T	ENST00000315567.8	+	9	1211	c.882C>T	c.(880-882)ttC>ttT	p.F294F		NM_020236.3	NP_064621.3	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1	294							RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)	17						TACGTGCTTTCCTTCGTAGTT	0.358000													32	77					0	0	1	0	0
SPRR2D	6703	broad.mit.edu	37	1	153012737	153012737	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153012737G>A	ENST00000368757.1	-	2	366	c.86C>T	c.(85-87)cCc>cTc	p.P29L	SPRR2D_ENST00000368756.1_Missense_Mutation_p.P29L|SPRR2D_ENST00000360379.3_Missense_Mutation_p.P29L|SPRR2D_ENST00000368758.3_Missense_Mutation_p.P29L			P22532	SPR2D_HUMAN	small proline-rich protein 2D	29	3 X 9 AA tandem repeats of P-K-C-P-[EQ]- P-C-P-[PS].				keratinization	cornified envelope|cytoplasm				endometrium(1)|skin(1)	2	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCACTTCGGGGGTGGACATGG	0.612000													68	123					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228525050	228525050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228525050C>T	ENST00000570156.2	+	77	19711	c.19637C>T	c.(19636-19638)tCc>tTc	p.S6546F	OBSCN_ENST00000366707.4_Missense_Mutation_p.S3223F|OBSCN_ENST00000422127.1_Missense_Mutation_p.S5589F|OBSCN_ENST00000284548.11_Missense_Mutation_p.S5589F|OBSCN_ENST00000366709.4_Missense_Mutation_p.S2708F	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5589	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGGAGTCTTCCTCAGAGTCA	0.647000													4	15					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087253	92087253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92087253G>A	ENST00000298047.6	+	1	1992	c.1975G>A	c.(1975-1977)Gag>Aag	p.E659K	FAT3_ENST00000541502.1_Missense_Mutation_p.E659K|FAT3_ENST00000409404.2_Missense_Mutation_p.E659K|FAT3_ENST00000525166.1_Missense_Mutation_p.E509K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	659	Cadherin 6.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AACTGATGGAGAGAATCTTGC	0.393000										TCGA Ovarian(4;0.039)			7	39					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140532181	140532181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140532181G>A	ENST00000231136.1	+	1	2343	c.2343G>A	c.(2341-2343)atG>atA	p.M781I	PCDHB6_ENST00000543635.1_Missense_Mutation_p.M645I	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		781					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGAGAAATGGAAGAAACCC	0.433000													9	85					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49585792	49585792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49585792C>T	ENST00000371175.4	-	3	507	c.481G>A	c.(481-483)Gaa>Aaa	p.E161K	RHAG_ENST00000229810.7_Missense_Mutation_p.E161K	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	161					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					TTAAATATTTCACTAACCAGG	0.383000													5	40					0	0	1	0	0
CD48	962	broad.mit.edu	37	1	160654665	160654665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160654665C>T	ENST00000368045.3	-	2	436	c.397G>A	c.(397-399)Gag>Aag	p.E133K	CD48_ENST00000368046.3_Intron			P09326	CD48_HUMAN	CD48 molecule	133	Ig-like C2-type 2.				blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|stomach(1)	10	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CTCTTTGGCTCCCCTGACTCA	0.542000													64	172					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165383628	165383628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165383628G>A	ENST00000263915.3	-	4	1037	c.499C>T	c.(499-501)Cac>Tac	p.H167Y	GRB14_ENST00000543549.1_Missense_Mutation_p.H80Y	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	167	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						ACCAGTTCGTGGTCTTCTATT	0.264000													24	79					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076249	9076249	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9076249G>A	ENST00000397910.4	-	3	11400	c.11197C>T	c.(11197-11199)Ctg>Ttg	p.L3733L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3734	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGAGTGGACAGAGAATCAAAC	0.498000													17	84					0	0	1	0	0
WNT2B	7482	broad.mit.edu	37	1	113059742	113059742	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113059742G>C	ENST00000369684.4	+	4	1166		c.e4-1		WNT2B_ENST00000256640.5_Splice_Site|WNT2B_ENST00000369686.4_Splice_Site	NM_024494.2	NP_078613.1	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B						chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCTCCCCCAGGCTGTGCGGC	0.567000													20	70					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628477	173628477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173628477G>A	ENST00000333279.2	-	2	141	c.81C>T	c.(79-81)gcC>gcT	p.A27A		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	43										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						ctggttcttgggcttcttctt	0.443000													9	22					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238303556	238303556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238303556C>T	ENST00000295550.4	-	3	835	c.383G>A	c.(382-384)aGc>aAc	p.S128N	COL6A3_ENST00000392004.3_Intron|COL6A3_ENST00000409809.1_Intron|COL6A3_ENST00000392003.2_Intron|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000346358.4_Missense_Mutation_p.S128N|COL6A3_ENST00000353578.4_Intron|COL6A3_ENST00000347401.3_Missense_Mutation_p.S128N	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	128	Nonhelical region.|VWFA 1.			QS -> AK (in Ref. 4; AAB24261).	axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGTGAGGTGGCTTTGCATTAT	0.478000													43	81					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51795149	51795149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51795149G>A	ENST00000251076.5	-	17	3133	c.2846C>T	c.(2845-2847)tCt>tTt	p.S949F	DMXL2_ENST00000543779.2_Missense_Mutation_p.S949F|DMXL2_ENST00000449909.3_Intron	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	949						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		CACACTAGGAGAGGTTTCTGG	0.418000													23	125					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99446978	99446978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:99446978G>A	ENST00000547776.2	-	17	2734	c.2735C>T	c.(2734-2736)tCg>tTg	p.S912L	ANKS1B_ENST00000547010.1_Missense_Mutation_p.S488L|ANKS1B_ENST00000329257.7_Missense_Mutation_p.S912L|ANKS1B_ENST00000549025.2_Missense_Mutation_p.S81L|ANKS1B_ENST00000547446.1_Missense_Mutation_p.S107L|ANKS1B_ENST00000549493.2_Missense_Mutation_p.S138L|ANKS1B_ENST00000549558.2_Missense_Mutation_p.S138L|ANKS1B_ENST00000546960.1_Missense_Mutation_p.S138L|ANKS1B_ENST00000546568.1_Missense_Mutation_p.S138L|ANKS1B_ENST00000332712.7_Missense_Mutation_p.S138L|ANKS1B_ENST00000550693.2_Missense_Mutation_p.S138L	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	912	SAM 2.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane		p.S912L(1)		NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CAGGTCCATCGAAGTGTAGCC	0.408000													3	10					0	0	1	0	0
SLC18A2	6571	broad.mit.edu	37	10	119029946	119029946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:119029946G>A	ENST00000298472.5	+	15	1555	c.1412G>A	c.(1411-1413)cGa>cAa	p.R471Q	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	471					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TTTTTTCTTCGAAGTCCACCT	0.393000													18	109					0	0	1	0	0
LAT2	7462	broad.mit.edu	37	7	73631186	73631186	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73631186G>A	ENST00000460943.1	+	4	1015	c.126G>A	c.(124-126)caG>caA	p.Q42Q	LAT2_ENST00000275635.7_Silent_p.Q42Q|LAT2_ENST00000398475.1_Silent_p.Q42Q|LAT2_ENST00000344995.5_Silent_p.Q42Q	NM_032464.2	NP_115853.2	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family, member 2	42					B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	6						TCTACCAGCAGAGAAGTCTGT	0.562000													13	70					0	0	1	0	0
LRP3	4037	broad.mit.edu	37	19	33696190	33696190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33696190C>T	ENST00000253193.7	+	5	716	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C	LRP3_ENST00000592484.1_3'UTR	NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	172	LDL-receptor class A 1.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					AGATGAGTTCCGCTGTGACAA	0.662000													3	11					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096187	167096187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167096187G>A	ENST00000361200.2	+	6	1985	c.1819G>A	c.(1819-1821)Gag>Aag	p.E607K	DUSP27_ENST00000271385.5_Missense_Mutation_p.E607K|DUSP27_ENST00000443333.1_Missense_Mutation_p.E607K|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	607					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GAACAAGGAGGAGGTGGTGGA	0.612000													5	30					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745185	140745185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140745185C>T	ENST00000518069.1	+	1	1288	c.1288C>T	c.(1288-1290)Ccg>Tcg	p.P430S	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGGAACCCCGCCCCTCTC	0.458000													45	115					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057754	9057754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9057754G>A	ENST00000397910.4	-	3	29895	c.29692C>T	c.(29692-29694)Ctt>Ttt	p.L9898F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9900	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTCCATAAAGGACTGCACTT	0.468000													28	89					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73964162	73964162	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73964162G>A	ENST00000373468.1	-	3	881	c.230C>T	c.(229-231)cCg>cTg	p.P77L	KIAA2022_ENST00000055682.5_Missense_Mutation_p.P77L			Q5QGS0	K2022_HUMAN	KIAA2022	77					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity	p.P77L(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						AGGAGAGGGCGGGCTCTGCAT	0.542000													31	21					0	0	1	0	0
MARC1	64757	broad.mit.edu	37	1	220970064	220970064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:220970064C>T	ENST00000366910.5	+	3	715	c.529C>T	c.(529-531)Ccc>Tcc	p.P177S	MARC1_ENST00000496110.1_3'UTR	NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	177							molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										GAAGTCACAGCCCTACCGCCT	0.602000													12	35					0	0	1	0	0
OR5P2	120065	broad.mit.edu	37	11	7817892	7817892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7817892C>T	ENST00000329434.2	-	1	628	c.598G>A	c.(598-600)Gga>Aga	p.G200R	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ATGATGGATCCAGAAGAAAAT	0.453000													8	83					0	0	1	0	0
LY6D	8581	broad.mit.edu	37	8	143867029	143867029	+	Missense_Mutation	SNP	G	G	A	rs144613234		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143867029G>A	ENST00000301263.4	-	2	202	c.127C>T	c.(127-129)Cgc>Tgc	p.R43C	LY6D_ENST00000518434.1_5'UTR|RP11-706C16.8_ENST00000510610.2_RNA	NM_003695.2	NP_003686.1	Q14210	LY6D_HUMAN	lymphocyte antigen 6 complex, locus D	43	UPAR/Ly6.				cell adhesion	anchored to membrane|membrane fraction|plasma membrane	protein binding			large_intestine(1)|lung(3)|prostate(1)	5	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TTGCAGAAGCGAGAGCTGGCC	0.637000													33	51					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214865	161214865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161214865C>T	ENST00000327928.4	+	1	270	c.270C>T	c.(268-270)ttC>ttT	p.F90F		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	90						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						TTGAAAACTTCACTCTTGACC	0.473000													34	155					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73636582	73636582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:73636582C>T	ENST00000377687.4	+	2	1381	c.845C>T	c.(844-846)cCc>cTc	p.P282L	KLF5_ENST00000477333.1_3'UTR|KLF5_ENST00000539231.1_Missense_Mutation_p.P191L	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	282					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CAGGGCATGCCCCCTTGCACA	0.507000													45	74					0	0	1	0	0
WBSCR27	155368	broad.mit.edu	37	7	73254755	73254755	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73254755G>A	ENST00000297873.4	-	4	426	c.377C>T	c.(376-378)cCc>cTc	p.P126L		NM_152559.2	NP_689772.2	Q8N6F8	WBS27_HUMAN	Williams Beuren syndrome chromosome region 27	126										NS(1)|central_nervous_system(1)|lung(2)|prostate(1)	5		Lung NSC(55;0.159)				TTCCGGGCTGGGCAGAGGCTC	0.652000													8	10					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8471043	8471043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8471043C>T	ENST00000381196.4	-	28	3999	c.3456G>A	c.(3454-3456)ggG>ggA	p.G1152G	PTPRD_ENST00000358503.5_Silent_p.G1130G|PTPRD_ENST00000397611.3_Silent_p.G738G|PTPRD_ENST00000356435.5_Silent_p.G1152G|PTPRD_ENST00000397617.3_Silent_p.G731G|PTPRD_ENST00000397606.3_Silent_p.G731G|PTPRD_ENST00000540109.1_Silent_p.G1152G|PTPRD_ENST00000360074.4_Silent_p.G1139G|PTPRD_ENST00000486161.1_Silent_p.G741G|PTPRD_ENST00000537002.1_Silent_p.G738G|PTPRD_ENST00000355233.5_Silent_p.G741G	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1152					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGATAAATTTCCCGCGAGATT	0.368000										TSP Lung(15;0.13)			13	121					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8449744	8449744	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8449744G>A	ENST00000381196.4	-	31	4512	c.3969C>T	c.(3967-3969)cgC>cgT	p.R1323R	PTPRD_ENST00000358503.5_Silent_p.R1301R|PTPRD_ENST00000397611.3_Silent_p.R913R|PTPRD_ENST00000356435.5_Silent_p.R1323R|PTPRD_ENST00000397617.3_Silent_p.R902R|PTPRD_ENST00000397606.3_Silent_p.R902R|PTPRD_ENST00000540109.1_Silent_p.R1323R|PTPRD_ENST00000360074.4_Silent_p.R1310R|PTPRD_ENST00000486161.1_Silent_p.R916R|PTPRD_ENST00000537002.1_Silent_p.R913R|PTPRD_ENST00000355233.5_Silent_p.R917R	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1323					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAAAGTTAAGGCGCCTCAGTT	0.453000										TSP Lung(15;0.13)			16	126					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064119	6064119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6064119C>T	ENST00000409021.3	-	10	1929	c.1480G>A	c.(1480-1482)Gag>Aag	p.E494K	JAKMIP1_ENST00000457227.2_Intron|JAKMIP1_ENST00000410077.2_Missense_Mutation_p.E329K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.E494K|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.E494K|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.E309K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	494	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCCTGGTACTCCCGGGTCAGC	0.587000													26	74					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52240817	52240817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52240817G>A	ENST00000282588.6	+	27	3788	c.3330G>A	c.(3328-3330)cgG>cgA	p.R1110R	CTD-2175A23.1_ENST00000503559.1_RNA|CTD-2175A23.1_ENST00000505701.1_RNA	NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	1110					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GAGAACTTCGGAGTGAAAATG	0.323000													20	175					0	0	1	0	0
HOXB13	10481	broad.mit.edu	37	17	46805893	46805893	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46805893C>T	ENST00000290295.7	-	1	647	c.63G>A	c.(61-63)gcG>gcA	p.A21A		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	21					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GCCCCCCTCCCGCTCCCAGCA	0.657000													17	16					0	0	1	0	0
CD3E	916	broad.mit.edu	37	11	118183390	118183390	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118183390G>A	ENST00000361763.4	+	6	452	c.161G>A	c.(160-162)gGa>gAa	p.G54E	CD3E_ENST00000528600.1_Missense_Mutation_p.G48E	NM_000733.3	NP_000724.1	P07766	CD3E_HUMAN	CD3e molecule, epsilon (CD3-TCR complex)	54	Ig-like.				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|ovary(2)|stomach(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	CAGTATCCTGGATCTGAAATA	0.413000													90	176					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103299894	103299894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103299894C>T	ENST00000233969.2	+	4	1321	c.1179C>T	c.(1177-1179)ttC>ttT	p.F393F		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	393						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						ACTGGGCCTTCGTCTGCTTCA	0.507000													8	75					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32466746	32466746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:32466746C>T	ENST00000357033.4	-	27	3819	c.3613G>A	c.(3613-3615)Gaa>Aaa	p.E1205K	DMD_ENST00000378677.2_Missense_Mutation_p.E1201K	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1205					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGGGCCTCTTCTTTAGCTCTC	0.348000													25	26					0	0	1	0	0
SLC35E4	339665	broad.mit.edu	37	22	31032727	31032727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31032727G>A	ENST00000343605.4	+	1	1089	c.290G>A	c.(289-291)gGg>gAg	p.G97E	SLC35E4_ENST00000406566.1_Missense_Mutation_p.G97E|SLC35E4_ENST00000300385.8_Missense_Mutation_p.G97E	NM_001001479.2	NP_001001479.1	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	97						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						TGCCACCGGGGGGCACGGCGC	0.667000													8	20					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187627274	187627274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:187627274C>T	ENST00000304698.5	+	8	2408	c.2205C>T	c.(2203-2205)atC>atT	p.I735I		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	735						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						AGCCCAAGATCCTTTACTTAG	0.488000													33	97					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90281242	90281242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90281242G>A	ENST00000405460.2	+	85	18151	c.18055G>A	c.(18055-18057)Gga>Aga	p.G6019R	GPR98_ENST00000425867.2_Missense_Mutation_p.G1680R	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6019					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTGAGTTGGGGACTACCAGC	0.418000													12	40					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142650990	142650990	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142650990C>T	ENST00000355265.2	-	9	1452	c.978G>A	c.(976-978)ccG>ccA	p.P326P	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	326					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCAGGGACATCGGTGTGAATG	0.522000													40	166					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39959963	39959963	+	Silent	SNP	C	C	T	rs147765614		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39959963C>T	ENST00000599117.1	+	17	1666	c.1299C>T	c.(1297-1299)ctC>ctT	p.L433L	SUPT5H_ENST00000359191.6_Silent_p.L429L|SUPT5H_ENST00000402194.2_Silent_p.L429L|SUPT5H_ENST00000598725.1_Silent_p.L433L|SUPT5H_ENST00000432763.2_Silent_p.L433L			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	433	KOW 2.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGGGTGAGCTCATCAACCTGC	0.612000													9	23					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159028717	159028717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:159028717G>A	ENST00000283233.5	-	14	1997	c.1684C>T	c.(1684-1686)Cat>Tat	p.H562Y	CCDC148_ENST00000409187.1_Missense_Mutation_p.H571Y|CCDC148-AS1_ENST00000412781.2_RNA	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	562										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						AGTGTTCTATGAAGTCCAGCT	0.323000													8	88					0	0	1	0	0
CLNK	116449	broad.mit.edu	37	4	10515185	10515185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:10515185C>T	ENST00000226951.6	-	16	1048	c.809G>A	c.(808-810)aGa>aAa	p.R270K	CLNK_ENST00000515667.1_Missense_Mutation_p.R8K	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	270					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						AGGCTGGCATCTCTGAGGAGA	0.493000													6	16					0	0	1	0	0
TAC3	6866	broad.mit.edu	37	12	57409509	57409509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57409509C>T	ENST00000458521.2	-	2	232	c.73G>A	c.(73-75)Gag>Aag	p.E25K	TAC3_ENST00000441881.1_Missense_Mutation_p.E25K|TAC3_ENST00000415231.1_Missense_Mutation_p.E25K	NM_013251.3	NP_037383.1	Q9UHF0	TKNK_HUMAN	tachykinin 3	25					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						TCCTGTGGCTCCTTACAGACA	0.597000													15	60					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541971	133541971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133541971G>A	ENST00000409261.1	-	14	2786	c.2413C>T	c.(2413-2415)Ccc>Tcc	p.P805S	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.P805S	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	805							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTGCCCCTGGGAGGTATTTTT	0.463000													21	282					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18333104	18333104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18333104C>T	ENST00000355502.3	-	6	1143	c.272G>A	c.(271-273)gGg>gAg	p.G91E	PDE4C_ENST00000594617.2_Missense_Mutation_p.G91E|PDE4C_ENST00000262805.11_Missense_Mutation_p.G59E|PDE4C_ENST00000594465.2_Missense_Mutation_p.G91E|PDE4C_ENST00000447275.2_5'UTR			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	91					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GGCCCTCCTCCCACACGAGAG	0.637000													6	65					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88173915	88173915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88173915G>A	ENST00000507897.1	+	13	1899	c.1816G>A	c.(1816-1818)Gaa>Aaa	p.E606K	C6orf165_ENST00000506888.1_3'UTR|C6ORF165_ENST00000369562.4_Missense_Mutation_p.E606K			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	606										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGGAAAGAGCGAAATCACCGA	0.458000													17	31					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182755102	182755102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:182755102G>A	ENST00000492597.1	-	12	1873	c.1171C>T	c.(1171-1173)Cgg>Tgg	p.R391W	MCCC1_ENST00000539926.1_Missense_Mutation_p.R365W|MCCC1_ENST00000489909.1_5'UTR|MCCC1_ENST00000265594.4_Missense_Mutation_p.R500W			Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	500	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	GCAGCCTTCCGACTGAGCAAC	0.507000													6	80					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35793034	35793034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35793034C>T	ENST00000342694.2	+	1	884	c.629C>T	c.(628-630)cCc>cTc	p.P210L		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	210					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CCAGGGGGCCCCGAGCAGGCC	0.637000													6	35					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36036043	36036043	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36036043G>A	ENST00000282507.3	-	7	1430	c.1329C>T	c.(1327-1329)atC>atT	p.I443I	UGT3A2_ENST00000545528.1_Silent_p.I141I|UGT3A2_ENST00000513300.1_Silent_p.I409I	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	443						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGGAGCGCAGGATGACACTGG	0.577000													11	38					0	0	1	0	0
DNAJC11	55735	broad.mit.edu	37	1	6741093	6741093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6741093G>A	ENST00000377577.5	-	2	200	c.77C>T	c.(76-78)tCt>tTt	p.S26F	DNAJC11_ENST00000542246.1_5'UTR|DNAJC11_ENST00000377573.5_5'UTR|DNAJC11_ENST00000349363.6_5'UTR|DNAJC11_ENST00000294401.7_Missense_Mutation_p.S26F	NM_018198.3	NP_060668.2	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	26	J.				protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTTCAGAAGAGGCCTAAAG	0.453000													10	90					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56057736	56057736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56057736C>T	ENST00000313022.2	-	1	830	c.803G>A	c.(802-804)gGa>gAa	p.G268E		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					TTGATCCCTTCCCAAAGAATA	0.338000													36	95					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111030	7111030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7111030G>A	ENST00000306904.5	+	1	866	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	227	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGACTACCGCGAACCCCGGGG	0.706000													8	24					0	0	1	0	0
NAALADL2	254827	broad.mit.edu	37	3	175184890	175184890	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:175184890G>A	ENST00000454872.1	+	8	1579	c.1451G>A	c.(1450-1452)gGg>gAg	p.G484E	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	484					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GTTAAGAGAGGGTGGAGACCA	0.423000													39	102					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101351026	101351026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101351026C>T	ENST00000534062.1	-	1	158	c.100G>A	c.(100-102)Gag>Aag	p.E34K		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	34										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						GACGTCGCCTCGGTGGTGTTG	0.572000													13	24					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10436605	10436605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10436605C>T	ENST00000245503.5	-	21	2822	c.2438G>A	c.(2437-2439)aGa>aAa	p.R813K	MYH2_ENST00000397183.2_Missense_Mutation_p.R813K|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	813	IQ.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTTATACCTTCTCTCCACCAT	0.433000													51	61					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151164261	151164261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151164261C>T	ENST00000282466.3	-	4	3507	c.3508G>A	c.(3508-3510)Gaa>Aaa	p.E1170K		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1170					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTTTTAGCTTCATTGGTGCTA	0.418000													106	273					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159571	18159571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18159571C>T	ENST00000396275.2	+	3	1183	c.822C>T	c.(820-822)ttC>ttT	p.F274F		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	274						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TTTACTTCTTCGTGGGCTCCT	0.512000													48	105					0	0	1	0	0
C19orf52	90580	broad.mit.edu	37	19	11040106	11040106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11040106C>T	ENST00000270502.6	+	2	601	c.511C>T	c.(511-513)Cgc>Tgc	p.R171C		NM_138358.2	NP_612367.1	Q9BSF4	CS052_HUMAN	chromosome 19 open reading frame 52	171										prostate(1)	1						CTTCGTGGGTCGCTGGTGGGT	0.701000													16	21					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210414947	210414947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210414947C>T	ENST00000367012.3	+	4	566	c.336C>T	c.(334-336)tcC>tcT	p.S112S	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	112	SERTA.						protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TTTATATGTCCTTAGAAAAGC	0.338000													23	113					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30803094	30803094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30803094G>A	ENST00000383096.3	-	18	2090	c.1908C>T	c.(1906-1908)acC>acT	p.T636T	CCDC178_ENST00000402325.1_Silent_p.T636T|CCDC178_ENST00000583930.1_Silent_p.T636T|CCDC178_ENST00000406524.2_Silent_p.T636T|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000579947.1_Silent_p.T636T|CCDC178_ENST00000403303.1_Silent_p.T636T|CCDC178_ENST00000300227.8_Intron					coiled-coil domain containing 178																		ATGCATCAAGGGTTTTCTTCC	0.279000													8	43					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170044495	170044495	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170044495C>T	ENST00000263816.3	-	49	9598	c.9313G>A	c.(9313-9315)Gat>Aat	p.D3105N		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3105	LDL-receptor class A 25.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCTTTCTCATCGCTGTTGTCC	0.483000													23	95					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179588821	179588821	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179588821C>T	ENST00000589042.1	-	73	21389	c.21165G>A	c.(21163-21165)ggG>ggA	p.G7055G	TTN_ENST00000342992.6_Silent_p.G5811G|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000591111.1_Silent_p.G6738G	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6738	Ig-like 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACCTAACACCCCACCAGTAT	0.433000													7	30					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20045034	20045034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20045034C>T	ENST00000343769.5	+	4	1298	c.1270C>T	c.(1270-1272)Ccc>Tcc	p.P424S	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	424						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						TGGAGAGAAACCCTACAAATG	0.408000													21	88					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57945727	57945727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57945727G>A	ENST00000564448.1	-	25	2464	c.2404C>T	c.(2404-2406)Ctt>Ttt	p.L802F	CNGB1_ENST00000251102.8_Missense_Mutation_p.L808F			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	808					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						CAGTAATAAAGACAGGAATTC	0.582000													15	43					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178555117	178555117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178555117G>A	ENST00000251582.7	-	17	2561	c.2460C>T	c.(2458-2460)gtC>gtT	p.V820V		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	820	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCACCGGGATGACCTGTGCCA	0.582000													16	46					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64608117	64608117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:64608117G>A	ENST00000357395.3	+	82	15334	c.4190G>A	c.(4189-4191)gGg>gAg	p.G1397E	SYNE2_ENST00000358025.3_Missense_Mutation_p.G5012E|SYNE2_ENST00000394768.2_Missense_Mutation_p.G1397E|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000554584.1_Missense_Mutation_p.G4929E|SYNE2_ENST00000344113.4_Missense_Mutation_p.G5012E|SYNE2_ENST00000555002.1_Missense_Mutation_p.G1646E			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5012					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATCAGTATCGGGAACCAGCTT	0.348000													25	80					0	0	1	0	0
MRPL4	51073	broad.mit.edu	37	19	10368916	10368916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10368916C>T	ENST00000393733.2	+	6	491	c.464C>T	c.(463-465)cCc>cTc	p.P155L	MRPL4_ENST00000253099.6_Missense_Mutation_p.P155L|MRPL4_ENST00000307422.5_Missense_Mutation_p.P155L|MRPL4_ENST00000588502.1_Missense_Mutation_p.P154L|CTD-2369P2.5_ENST00000592893.1_RNA|MRPL4_ENST00000590669.1_Missense_Mutation_p.P155L			Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4	155					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		GCCCATGGCCCCCGGGGCCCC	0.637000													5	39					0	0	1	0	0
MBLAC2	153364	broad.mit.edu	37	5	89757138	89757138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89757138G>A	ENST00000316610.6	-	2	1161	c.686C>T	c.(685-687)cCt>cTt	p.P229L		NM_203406.1	NP_981951.1	Q68D91	MBLC2_HUMAN	metallo-beta-lactamase domain containing 2	229							hydrolase activity|metal ion binding			kidney(1)|liver(1)|lung(3)	5						GAAGTGCCCAGGAAGCACCTT	0.423000													15	114					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819642	159819642	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159819642G>A	ENST00000497452.1	-	0	517																											GTGCGAATTTGAAAGAAGAAA	0.488000													68	171					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657088	143657088	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143657088G>A	ENST00000392899.1	+	1	62	c.25G>A	c.(25-27)Gtg>Atg	p.V9M		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					CCAGACTTGGGTGAGTGAATT	0.428000													15	159					0	0	1	0	0
NCEH1	57552	broad.mit.edu	37	3	172428810	172428810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172428810G>A	ENST00000538775.1	-	1	198	c.61C>T	c.(61-63)Ctt>Ttt	p.L21F	NCEH1_ENST00000273512.3_Missense_Mutation_p.L21F|NCEH1_ENST00000475381.1_5'UTR|NCEH1_ENST00000543711.1_5'UTR	NM_001146276.1	NP_001139748.1	Q6PIU2	NCEH1_HUMAN	neutral cholesterol ester hydrolase 1	0					lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)	15						GGCTGGCAAAGAGGAAAGGGC	0.627000											OREG0015927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	64					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175304863	175304863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175304863C>T	ENST00000367674.1	-	20	4323	c.3615G>A	c.(3613-3615)gaG>gaA	p.E1205E	TNR_ENST00000263525.2_Silent_p.E1205E	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1205	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					AGAACTCATCCTCCACGTTCC	0.443000													10	121					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839224	62839224	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62839224C>T	ENST00000536311.1	+	7	1039	c.675C>T	c.(673-675)gtC>gtT	p.V225V	MYT1_ENST00000328439.1_Silent_p.V225V|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	225	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGGAGGTCGTCGAAGTCACCA	0.617000													13	31					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30890998	30890998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30890998C>T	ENST00000321897.5	+	23	2935	c.2303C>T	c.(2302-2304)cCt>cTt	p.P768L	VARS2_ENST00000542001.1_Missense_Mutation_p.P628L|VARS2_ENST00000541562.1_Missense_Mutation_p.P798L|VARS2_ENST00000416670.2_Missense_Mutation_p.P768L|VARS2_ENST00000476162.1_3'UTR			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	768					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						GTGCCACAGCCTGCTGAGGAG	0.532000													30	130					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23758277	23758277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23758277C>T	ENST00000336689.3	-	23	2502	c.2458G>A	c.(2458-2460)Gag>Aag	p.E820K	ASAP3_ENST00000495646.1_Missense_Mutation_p.E324K|ASAP3_ENST00000437606.2_Missense_Mutation_p.E811K|ASAP3_ENST00000484906.1_Intron	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	820					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						CGGAGGCCCTCTTCAGAGTTG	0.652000													46	107					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75977862	75977862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75977862G>A	ENST00000308508.5	-	4	4062	c.3970C>T	c.(3970-3972)Cgc>Tgc	p.R1324C		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1324	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GCCTCAGGGCGGGAGTGCAGG	0.682000													5	17					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62330131	62330131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62330131G>A	ENST00000371158.2	+	20	2775	c.2661G>A	c.(2659-2661)gaG>gaA	p.E887E	INADL_ENST00000316485.6_Silent_p.E887E	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	887					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CATCCATGGAGTTGTATCCCT	0.418000													29	89					0	0	1	0	0
FAM114A1	92689	broad.mit.edu	37	4	38937369	38937369	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:38937369C>T	ENST00000358869.2	+	13	1670	c.1494C>T	c.(1492-1494)gcC>gcT	p.A498A	FAM114A1_ENST00000515037.1_Silent_p.A291A|FAM114A1_ENST00000513966.1_3'UTR	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1	498						cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						ATGAAGTGGCCTCTTTATCAA	0.323000													13	73					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638545	234638545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234638545G>A	ENST00000482026.1	+	1	792	c.773G>A	c.(772-774)cGa>cAa	p.R258Q	UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A9_ENST00000354728.4_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TGGCTGTTCCGAGGGGACTTT	0.507000													99	231					0	0	1	0	0
NUP107	57122	broad.mit.edu	37	12	69109411	69109411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:69109411C>T	ENST00000229179.4	+	12	1306	c.974C>T	c.(973-975)cCt>cTt	p.P325L	NUP107_ENST00000539906.1_Missense_Mutation_p.P296L|NUP107_ENST00000378905.2_Missense_Mutation_p.P174L	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	325					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TTACAGGACCCTGATGCTCCC	0.358000													43	95					0	0	1	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077169	19077169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:19077169G>A	ENST00000329773.2	-	2	868	c.781C>T	c.(781-783)Cat>Tat	p.H261Y		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	261					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						GAAACTGGATGAATATGACAA	0.483000													34	87					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61687892	61687892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:61687892C>T	ENST00000577390.1	-	12	2974	c.2020G>A	c.(2020-2022)Gag>Aag	p.E674K	CDH8_ENST00000299345.6_Missense_Mutation_p.E674K|CDH8_ENST00000577730.1_Missense_Mutation_p.E674K	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	674					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GTGTCCTCCTCCCCTCCTCCT	0.383000													61	134					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87026001	87026001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87026001C>T	ENST00000370563.3	+	3	450	c.408C>T	c.(406-408)gaC>gaT	p.D136D	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	136						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TCACCCCTGACCTTCTACTTG	0.388000													35	69					0	0	1	0	0
SF3B2	10992	broad.mit.edu	37	11	65829159	65829159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65829159G>A	ENST00000528302.1	+	14	1785	c.1731G>A	c.(1729-1731)ggG>ggA	p.G577G	SF3B2_ENST00000322535.6_Silent_p.G594G			Q13435	SF3B2_HUMAN	splicing factor 3b, subunit 2, 145kDa	594					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	41						TCCCTCAGGGGAAGGAGTTCG	0.502000													17	48					0	0	1	0	0
MNX1	3110	broad.mit.edu	37	7	156798568	156798568	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:156798568C>T	ENST00000252971.6	-	3	1153		c.e3-1		MNX1_ENST00000543409.1_Splice_Site|MNX1_ENST00000469500.1_Intron	NM_005515.3	NP_005506.3	P50219	MNX1_HUMAN	motor neuron and pancreas homeobox 1						humoral immune response|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(4)|skin(1)	7	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAATCTTCACCTGCGGGCACA	0.672000													14	55					0	0	1	0	0
IGHV3-35	28432	broad.mit.edu	37	14	106845368	106845368	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106845368C>T	ENST00000390617.2	-	0	320																											TCAGGCTATTCGTTTGCAGAT	0.517000													54	224					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476410	57476410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57476410C>T	ENST00000371236.2	-	14	1889	c.1626G>A	c.(1624-1626)ggG>ggA	p.G542G	DAB1_ENST00000371231.1_Silent_p.G575G|DAB1_ENST00000439789.2_Silent_p.G456G|DAB1_ENST00000371234.4_Silent_p.G542G|DAB1_ENST00000420954.2_Silent_p.G540G|DAB1_ENST00000414851.2_Silent_p.G524G|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	575					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CACTGGGCTCCCCACTGGGCT	0.448000													12	129					0	0	1	0	0
IQCH	64799	broad.mit.edu	37	15	67713779	67713779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:67713779C>T	ENST00000335894.4	+	16	2435	c.2369C>T	c.(2368-2370)cCt>cTt	p.P790L	IQCH_ENST00000360277.4_Missense_Mutation_p.P451L|IQCH_ENST00000546225.1_Missense_Mutation_p.P447L|IQCH_ENST00000358767.3_Missense_Mutation_p.P526L|IQCH-AS1_ENST00000559298.1_lincRNA	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	790										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		ACCACCGTGCCTCAGACCTCA	0.507000													18	92					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5567942	5567942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5567942G>A	ENST00000331789.5	-	4	963	c.772C>T	c.(772-774)Cct>Tct	p.P258S		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	258					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		AGTGCCTCAGGGCAGCGGAAC	0.617000													36	94					0	0	1	0	0
EDDM3A	10876	broad.mit.edu	37	14	21216087	21216087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21216087G>A	ENST00000326842.2	+	2	475	c.348G>A	c.(346-348)gaG>gaA	p.E116E		NM_006683.4	NP_006674.2	Q14507	EP3A_HUMAN	epididymal protein 3A	116					sperm displacement	extracellular space				breast(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	6						GGTACACAGAGAGCAGAAGCT	0.443000													20	63					0	0	1	0	0
FNDC4	64838	broad.mit.edu	37	2	27715556	27715556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27715556C>T	ENST00000264703.3	-	6	1037	c.646G>A	c.(646-648)Gga>Aga	p.G216R		NM_022823.2	NP_073734.1	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	216						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|prostate(1)|skin(1)	9	Acute lymphoblastic leukemia(172;0.155)					ACTGGCCTTCCCTGAGGACTC	0.557000													35	144					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130060507	130060507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130060507C>T	ENST00000278742.5	+	7	1211	c.793C>T	c.(793-795)Ctt>Ttt	p.L265F		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	265	CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	CAGCTTTGACCTTGCGTCCTG	0.701000													7	22					0	0	1	0	0
DIABLO	56616	broad.mit.edu	37	12	122702927	122702927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122702927G>A	ENST00000535844.1	-	13	1626	c.1612C>T	c.(1612-1614)Cct>Tct	p.P538S	DIABLO_ENST00000353548.6_Intron|DIABLO_ENST00000267169.6_Silent_p.S14S|DIABLO_ENST00000413918.1_Intron|DIABLO_ENST00000464942.2_Silent_p.S14S|DIABLO_ENST00000443649.3_Silent_p.S67S																							CACTACTAAGGGAATGAGGCT	0.398000													13	82					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54958874	54958874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54958874C>T	ENST00000273286.5	-	2	538	c.376G>A	c.(376-378)Gag>Aag	p.E126K	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.E50K|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000490478.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	126						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		AAATCAAGCTCCCTCAGCTGA	0.463000													20	57					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94487106	94487106	+	Missense_Mutation	SNP	G	G	A	rs56099091	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:94487106G>A	ENST00000375708.3	-	9	1868	c.1670C>T	c.(1669-1671)tCg>tTg	p.S557L	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Missense_Mutation_p.S417L	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	557	Protein kinase.		S -> L (in dbSNP:rs56099091).		negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.S557L(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GTCGCCGTGCGAACAGTAGCT	0.652000													9	47					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71839936	71839936	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71839936G>A	ENST00000258104.3	+	39	4610	c.4333_splice	c.e39+1	p.D1445_splice	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Splice_Site_p.D1446_splice|DYSF_ENST00000409744.1_Splice_Site_p.D1432_splice|DYSF_ENST00000410020.3_Splice_Site_p.D1463_splice|DYSF_ENST00000413539.2_Splice_Site_p.D1476_splice|DYSF_ENST00000429174.2_Splice_Site_p.D1445_splice|DYSF_ENST00000409366.1_Splice_Site_p.D1446_splice|DYSF_ENST00000409582.3_Splice_Site_p.D1462_splice|DYSF_ENST00000409762.1_Splice_Site_p.D1462_splice|DYSF_ENST00000409651.1_Splice_Site_p.D1477_splice|DYSF_ENST00000410041.1_Splice_Site_p.D1463_splice	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1445						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						GGGTGGCCCAGGTAGGGGAAG	0.632000													7	28					0	0	1	0	0
TEX37	200523	broad.mit.edu	37	2	88828854	88828854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:88828854C>T	ENST00000303254.3	+	4	547	c.405C>T	c.(403-405)ctC>ctT	p.L135L		NM_152670.2	NP_689883.1			testis expressed 37																		TTCCGTGCCTCGTGGATCCCA	0.572000													29	62					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35829247	35829247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35829247C>T	ENST00000085219.5	+	6	1228	c.1162C>T	c.(1162-1164)Ccc>Tcc	p.P388S	CD22_ENST00000419549.2_Missense_Mutation_p.P216S|CD22_ENST00000341773.6_Intron|CD22_ENST00000536635.2_Intron|CD22_ENST00000270311.6_Missense_Mutation_p.P268S|CD22_ENST00000544992.2_Missense_Mutation_p.P388S|CD22_ENST00000594250.1_Intron	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	388	Ig-like C2-type 3.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AAAGATCCTCCCCTGGCACGC	0.532000													31	80					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897943	175897943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175897943C>T	ENST00000359240.3	+	5	1937	c.1267C>T	c.(1267-1269)Ccc>Tcc	p.P423S	ADAM29_ENST00000404450.4_Missense_Mutation_p.P423S|ADAM29_ENST00000445694.1_Missense_Mutation_p.P423S|ADAM29_ENST00000514159.1_Missense_Mutation_p.P423S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	423	Disintegrin.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGCAAAAGATCCCTGCTGTCT	0.443000													33	91					0	0	1	0	0
ANKRD20A11P	391267	broad.mit.edu	37	21	15352085	15352085	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:15352085C>T	ENST00000344693.5	-	0	673					NR_027270.1																						GCTCCATCTCCGCGGCGTCGC	0.667000													5	29					0	0	1	0	0
CHIAP2	149620	broad.mit.edu	37	1	111827633	111827633	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111827633G>A	ENST00000369743.4	+	0	1732					NR_003928.1																						CAACTTTGGAGGTGCCATGGT	0.488000													3	6					0	0	1	0	0
HTRA1	5654	broad.mit.edu	37	10	124248484	124248484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124248484C>T	ENST00000368984.3	+	2	667	c.539C>T	c.(538-540)gCc>gTc	p.A180V		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	180					proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				GAGAAGATCGCCCCTGCCGTG	0.448000													37	108					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108872124	108872124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108872124G>A	ENST00000329106.2	+	4	496	c.496G>A	c.(496-498)Gaa>Aaa	p.E166K	SULT1C3_ENST00000376700.1_Missense_Mutation_p.E166K	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	166						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						GAACTTAGAGGAATTTTATGA	0.428000													7	94					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58620087	58620087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58620087C>T	ENST00000358781.2	-	10	904	c.594G>A	c.(592-594)aaG>aaA	p.K198K	RP11-475O23.3_ENST00000464125.1_RNA	NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	198					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CTGGGCTGTTCTTTAAGAACT	0.507000													34	79					0	0	1	0	0
NR3C1	2908	broad.mit.edu	37	5	142779665	142779665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:142779665G>A	ENST00000343796.2	-	2	1733	c.740C>T	c.(739-741)cCt>cTt	p.P247L	NR3C1_ENST00000394464.2_Missense_Mutation_p.P247L|NR3C1_ENST00000416954.2_Intron|NR3C1_ENST00000415690.2_Missense_Mutation_p.P247L|NR3C1_ENST00000503201.1_Missense_Mutation_p.P247L|NR3C1_ENST00000424646.2_Missense_Mutation_p.P247L|NR3C1_ENST00000504572.1_Missense_Mutation_p.P247L|NR3C1_ENST00000231509.3_Missense_Mutation_p.P247L|NR3C1_ENST00000394466.2_Missense_Mutation_p.P247L	NM_001018074.1|NM_001018075.1|NM_001018077.1	NP_001018084.1|NP_001018085.1|NP_001018087.1	P04150	GCR_HUMAN	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	247	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	35		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TAAAATGAGAGGCTTGCAGTC	0.423000													59	137					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62941524	62941524	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62941524G>A	ENST00000251157.5	-	45	5815	c.5782C>T	c.(5782-5784)Cgt>Tgt	p.R1928C	DOCK7_ENST00000340370.5_Missense_Mutation_p.R1908C|DOCK7_ENST00000489185.1_5'UTR	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1939	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						ATGAATCGACGAAGATTGTAA	0.403000													48	121					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711093	58711093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58711093G>A	ENST00000300079.5	+	2	152	c.102G>A	c.(100-102)caG>caA	p.Q34Q	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_5'UTR	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	0						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	ggtacctgcaggatccaattg	0.473000													13	43					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471412	47471412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:47471412C>T	ENST00000266581.4	-	2	1840	c.1374G>A	c.(1372-1374)cgG>cgA	p.R458R	AMIGO2_ENST00000429635.1_Silent_p.R458R|AMIGO2_ENST00000321382.3_Silent_p.R458R|AMIGO2_ENST00000550413.1_Silent_p.R458R	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	458					heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					CACCTGCCTTCCGTTCATCAG	0.512000													17	67					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18897384	18897384	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18897384C>T	ENST00000542601.2	-	10	1502	c.1113G>A	c.(1111-1113)ggG>ggA	p.G371G	COMP_ENST00000222271.2_Silent_p.G404G|COMP_ENST00000425807.1_Silent_p.G351G			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	404			C -> S (in EDM1; Fairbank type).		anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						CACAGGCATCCCCTATACCAT	0.582000													14	54					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220312757	220312757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220312757G>A	ENST00000312358.7	+	4	1009	c.877G>A	c.(877-879)Gaa>Aaa	p.E293K	SPEG_ENST00000396698.1_Missense_Mutation_p.E189K|SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	293	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ACTGGCCAGCGAAGCCCCACG	0.706000													8	27					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10514928	10514928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10514928G>A	ENST00000444303.2	+	6	967	c.495G>A	c.(493-495)atG>atA	p.M165I	AMPD3_ENST00000396554.3_Missense_Mutation_p.M333I	NM_001172431.1	NP_001165902.1	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3	324					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CCGCCTGCATGAACCAAAAGC	0.597000													41	142					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68699036	68699036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68699036G>A	ENST00000283916.6	-	7	676	c.578C>T	c.(577-579)gCt>gTt	p.A193V	TMPRSS11D_ENST00000509584.1_5'UTR|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11D_ENST00000545541.1_Missense_Mutation_p.A76V	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	193	Peptidase S1.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						TCCCTCCTCAGCCTCAGTGCC	0.522000													47	151					0	0	1	0	0
ZNF418	147686	broad.mit.edu	37	19	58438240	58438240	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58438240G>A	ENST00000396147.1	-	4	1600	c.1309C>T	c.(1309-1311)Cga>Tga	p.R437*	ZNF418_ENST00000425570.3_Nonsense_Mutation_p.R458*|ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000599852.1_Nonsense_Mutation_p.R352*|ZNF418_ENST00000595830.1_Nonsense_Mutation_p.R437*	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TTGCCCTTTCGACTAAAAGAT	0.468000													69	211					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107012559	107012559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:107012559C>T	ENST00000369701.3	+	23	3359	c.3132C>T	c.(3130-3132)atC>atT	p.I1044I		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1044						integral to membrane	neuropeptide receptor activity	p.I1044I(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGGACCAGATCCTCATTGCCG	0.527000													46	98					0	0	1	0	0
CD200R1L	344807	broad.mit.edu	37	3	112545989	112545989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112545989C>T	ENST00000488794.1	-	6	1056	c.467G>A	c.(466-468)gGa>gAa	p.G156E	CD200R1L_ENST00000398214.1_Missense_Mutation_p.G177E|CD200R1L_ENST00000448932.1_Missense_Mutation_p.G156E			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	177	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						AAGAATAGATCCCTCTGGGAT	0.507000													13	35					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110489561	110489561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110489561G>A	ENST00000378402.5	+	53	9129	c.9025G>A	c.(9025-9027)Gat>Aat	p.D3009N		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3009					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATTCTCCAGGATTGCTTTCC	0.408000										HNSCC(38;0.096)			19	52					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36257174	36257174	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36257174C>T	ENST00000296604.3	-	10	1258		c.e10-1		RANBP3L_ENST00000502994.1_Splice_Site|RANBP3L_ENST00000515759.1_Splice_Site	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like						intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GAGTCTGTTCCTAAGAGAAAA	0.368000													19	78					0	0	1	0	0
DMGDH	29958	broad.mit.edu	37	5	78340231	78340231	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78340231G>A	ENST00000255189.3	-	6	918	c.890C>T	c.(889-891)tCa>tTa	p.S297L	DMGDH_ENST00000540686.1_Intron|DMGDH_ENST00000380311.4_Missense_Mutation_p.S96L	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	297					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		GAGATAATATGATCCTTCCAG	0.438000													45	107					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156496304	156496304	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156496304G>A	ENST00000361170.2	-	38	4880	c.4870C>T	c.(4870-4872)Ctc>Ttc	p.L1624F		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1624					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTCTTGTTGAGGAGGAAGATG	0.488000													13	52					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28918362	28918362	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28918362G>A	ENST00000257192.4	+	10	1562	c.1350G>A	c.(1348-1350)aaG>aaA	p.K450K		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	450	Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AAGTTACCAAGGAACAGTACA	0.338000													21	68					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75900468	75900468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:75900468G>A	ENST00000377636.3	-	10	2244	c.1898C>T	c.(1897-1899)tCc>tTc	p.S633F	TBC1D4_ENST00000377625.2_Missense_Mutation_p.S633F|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000431480.2_Missense_Mutation_p.S633F	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	633						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AAACTGCGGGGAGTCGGAATC	0.582000													16	44					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17539536	17539536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17539536C>T	ENST00000229922.2	+	8	1205	c.673C>T	c.(673-675)Ctc>Ttc	p.L225F	CAP2_ENST00000489374.1_Missense_Mutation_p.L113F|CAP2_ENST00000493172.1_Intron|CAP2_ENST00000465994.1_Missense_Mutation_p.L161F|CAP2_ENST00000378990.2_Missense_Mutation_p.L199F	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	225					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			GTTTTCTGTCCTCTCCTCTGG	0.552000													34	180					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26825586	26825586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:26825586C>T	ENST00000541819.2	-	7	832	c.730G>A	c.(730-732)Gac>Aac	p.D244N	GABRB3_ENST00000545868.1_Missense_Mutation_p.D103N|GABRB3_ENST00000400188.3_Missense_Mutation_p.D117N|GABRB3_ENST00000299267.4_Missense_Mutation_p.D188N|GABRB3_ENST00000311550.5_Missense_Mutation_p.D188N			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	188					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AACTCAATGTCATCCGTGGTG	0.507000													30	80					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8808591	8808591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8808591C>T	ENST00000324436.3	-	1	581	c.461G>A	c.(460-462)aGc>aAc	p.S154N		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	154						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						GGTGGCCGGGCTGAAGGGTGG	0.672000													20	56					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13749204	13749204	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:13749204C>T	ENST00000532502.1	+	2	2059	c.231C>T	c.(229-231)ctC>ctT	p.L77L	FAR1_ENST00000354817.3_Silent_p.L453L			Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	453					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						TGTCTGGCCTCCCTGCAGCCA	0.383000													24	93					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73042718	73042718	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73042718G>A	ENST00000604411.1	+	0	30679				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCTACTCAATGAAGTTTCTTC	0.353000													17	13					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212745	62212745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:62212745G>A	ENST00000519846.1	+	3	831	c.359G>A	c.(358-360)aGg>aAg	p.R120K	CLVS1_ENST00000518592.1_Intron|CLVS1_ENST00000325897.4_Missense_Mutation_p.R120K|RP11-787D18.1_ENST00000518064.1_RNA			Q8IUQ0	CLVS1_HUMAN	clavesin 1	120	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						GGCATTAAGAGGGCTCTGATC	0.502000													23	42					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209803966	209803966	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209803966A>T	ENST00000391911.1	-	8	1326	c.937T>A	c.(937-939)Tgc>Agc	p.C313S	LAMB3_ENST00000356082.4_Missense_Mutation_p.C313S|LAMB3_ENST00000367030.3_Missense_Mutation_p.C313S	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	313	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CTACTTTGGCATTCATGGGCG	0.617000													21	64					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82834820	82834820	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82834820C>T	ENST00000265077.3	+	8	6563	c.5998C>T	c.(5998-6000)Ccc>Tcc	p.P2000S	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.P1013S|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2000	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTCAGCCTTCCCCTGGGAAGA	0.512000													22	54					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96970493	96970493	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96970493C>T	ENST00000341686.3	+	5	823	c.698C>T	c.(697-699)cCc>cTc	p.P233L	C10orf129_ENST00000430183.1_Missense_Mutation_p.P78L|C10orf129_ENST00000394005.3_Missense_Mutation_p.P233L	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	233					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		ACAGGAGCTCCCAAAATGGTC	0.507000													24	57					0	0	1	0	0
ZFP41	286128	broad.mit.edu	37	8	144332487	144332487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144332487C>T	ENST00000330701.4	+	2	843	c.474C>T	c.(472-474)ctC>ctT	p.L158L	ZFP41_ENST00000522452.1_Silent_p.L158L|ZFP41_ENST00000520584.1_Silent_p.L158L	NM_173832.3	NP_776193.1	Q8N8Y5	ZFP41_HUMAN	ZFP41 zinc finger protein	158					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|lung(4)|ovary(1)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GCTCCAATCTCCTGAAACATC	0.562000													52	117					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810712	65810712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65810712C>T	ENST00000312006.4	-	3	843	c.562G>A	c.(562-564)Gag>Aag	p.E188K	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.E188K	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	188					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						TAGTATGCCTCGGGCGCGCGC	0.677000													11	38					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196642646	196642646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196642646C>T	ENST00000312428.6	-	59	11042	c.10942G>A	c.(10942-10944)Gat>Aat	p.D3648N	DNAH7_ENST00000409063.1_Missense_Mutation_p.D131N	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3648					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.D3648N(1)		NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TCCCAGTCATCGGTCACTCTG	0.473000													17	54					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171173122	171173122	+	Missense_Mutation	SNP	G	G	A	rs147029269	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171173122G>A	ENST00000441535.1	+	6	863	c.746G>A	c.(745-747)cGa>cAa	p.R249Q	FMO2_ENST00000209929.7_Missense_Mutation_p.R249Q|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445290.1_RNA|RP1-127D3.4_ENST00000422841.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	249					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTACTGCCACGAACAGCTGTA	0.453000													22	61					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57349320	57349320	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57349320C>T	ENST00000361249.3	+	6	917	c.821C>T	c.(820-822)tCa>tTa	p.S274L		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	274	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CAAGACACTTCATTCTTGAAC	0.403000													15	51					0	0	1	0	0
CECR5	27440	broad.mit.edu	37	22	17624020	17624020	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17624020G>A	ENST00000336737.4	-	5	564	c.537_splice	c.e5-1	p.P180_splice	CECR5_ENST00000399852.3_Splice_Site_p.P43_splice|CECR5_ENST00000155674.5_Splice_Site_p.P150_splice	NM_033070.2	NP_149061.1	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	180							hydrolase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(10)|pancreas(1)|prostate(1)	21		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				CCTCGGGAGGGGCTGCAGAGA	0.577000													10	45					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66322807	66322807	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66322807C>T	ENST00000513398.1	+	0	784				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						CAGAGAAATACCTGGACATCC	0.562000													22	89					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21690356	21690356	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21690356G>A	ENST00000388958.3	+	3	121		c.e3-1		OTOA_ENST00000286149.4_Splice_Site	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin						sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		TTGCCTTTTAGGAAGAAATAA	0.383000													24	200					0	0	1	0	0
U2AF1L4	199746	broad.mit.edu	37	19	36233574	36233574	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36233574G>A	ENST00000292879.5	-	6	587	c.534C>T	c.(532-534)tcC>tcT	p.S178S	AD000671.6_ENST00000589807.1_Intron|U2AF1L4_ENST00000378975.3_3'UTR|U2AF1L4_ENST00000412391.2_3'UTR	NM_144987.2	NP_659424.2	Q8WU68	U2AF4_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 4	0					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	8	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGTCCTGCCAGGAACATCTGT	0.597000													28	103					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138453098	138453098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138453098C>T	ENST00000344876.4	-	1	531	c.145G>A	c.(145-147)Gag>Aag	p.E49K	PCDH18_ENST00000412923.2_Missense_Mutation_p.E49K|PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	49	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					GCCACATCCTCTGATAGTCTT	0.408000													34	87					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218305	130218305	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130218305G>A	ENST00000276211.5	+	5	1017	c.672G>A	c.(670-672)agG>agA	p.R224R	ARHGAP36_ENST00000370921.1_Silent_p.R88R|ARHGAP36_ENST00000370922.1_Silent_p.R212R	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	224					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GATCCAAAAGGAAGATGAGTC	0.478000													26	12					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2297376	2297376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2297376G>A	ENST00000222990.3	-	8	1020	c.978C>T	c.(976-978)tcC>tcT	p.S326S		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	326					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		TCACCTTATAGGACTGCAGCA	0.567000													67	273					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123887067	123887067	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123887067C>T	ENST00000320891.4	+	1	786	c.786C>T	c.(784-786)ggC>ggT	p.G262G		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGAGGCCAGGCTCCATGGATG	0.522000													15	60					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76777849	76777849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:76777849G>A	ENST00000373344.5	-	32	7081	c.6867C>T	c.(6865-6867)ttC>ttT	p.F2289F	ATRX_ENST00000395603.3_Silent_p.F2251F|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2289					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TTGGTATGTTGAAACGCATGG	0.368000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						39	27					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124397119	124397119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124397119C>T	ENST00000360013.3	+	50	7403	c.7276C>T	c.(7276-7278)Cgt>Tgt	p.R2426C	KALRN_ENST00000462213.1_Missense_Mutation_p.R43C|KALRN_ENST00000291478.4_Missense_Mutation_p.R729C|KALRN_ENST00000428018.2_Missense_Mutation_p.R697C	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2425					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CACAGGGCCTCGTAAACCCAA	0.498000													27	100					0	0	1	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19564139	19564139	+	Silent	SNP	G	G	A	rs148651015	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:19564139G>A	ENST00000397821.3	-	15	1814	c.1524C>T	c.(1522-1524)gaC>gaT	p.D508D	SH3KBP1_ENST00000379716.1_Silent_p.D270D|SH3KBP1_ENST00000379698.4_Silent_p.D471D|SH3KBP1_ENST00000541422.1_Silent_p.D247D	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	508					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						GACTTGGGGAGTCGAAGATAT	0.433000													19	16					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94700041	94700041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94700041C>T	ENST00000304338.3	+	6	722	c.568C>T	c.(568-570)Cgt>Tgt	p.R190C		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	190						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AGTCCAGTCTCGTTTAGTTAG	0.303000													39	111					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157985168	157985168	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157985168C>T	ENST00000389413.3	-	5	503	c.400G>A	c.(400-402)Ggc>Agc	p.G134S	PTPRN2_ENST00000389416.4_Missense_Mutation_p.G117S|PTPRN2_ENST00000404321.2_Missense_Mutation_p.G157S|PTPRN2_ENST00000389418.4_Missense_Mutation_p.G134S|PTPRN2_ENST00000409483.1_Missense_Mutation_p.G96S	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	134						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CTCTCGCTGCCAACGCTGTGT	0.637000													18	86					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	994959	994959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:994959C>T	ENST00000537687.1	+	19	6412	c.5769C>T	c.(5767-5769)ttC>ttT	p.F1923F	WNK1_ENST00000535572.1_Silent_p.F1416F|WNK1_ENST00000315939.6_Silent_p.F1663F|WNK1_ENST00000530271.2_Silent_p.F2161F|WNK1_ENST00000340908.4_Silent_p.F1256F	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1663					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GGTCTCTGTTCAGTGAACACA	0.483000													21	60					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9389291	9389291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9389291C>T	ENST00000378501.2	+	19	1780	c.1765C>T	c.(1765-1767)Cat>Tat	p.H589Y	PLCB4_ENST00000414679.2_Missense_Mutation_p.H601Y|PLCB4_ENST00000378493.1_Missense_Mutation_p.H589Y|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.H589Y|PLCB4_ENST00000378473.3_Missense_Mutation_p.H601Y|PLCB4_ENST00000334005.3_Missense_Mutation_p.H589Y	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	589	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						ACGCAATATTCATTATAACAT	0.358000													7	24					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11718434	11718434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11718434C>T	ENST00000381486.2	+	6	949	c.649C>T	c.(649-651)Cgg>Tgg	p.R217W	GREB1_ENST00000389825.3_Missense_Mutation_p.R107W|GREB1_ENST00000234142.5_Missense_Mutation_p.R217W|GREB1_ENST00000263834.5_Missense_Mutation_p.R217W|GREB1_ENST00000381483.2_Missense_Mutation_p.R217W	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	217						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GTTTAGAAGCCGGCAGATCCC	0.577000													79	131					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10357094	10357094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10357094C>T	ENST00000255381.2	-	23	2910	c.2800G>A	c.(2800-2802)Gaa>Aaa	p.E934K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	934					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTGATCTCTTCCTCATCCTCA	0.443000													110	247					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49668450	49668450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49668450C>T	ENST00000339139.4	-	5	350	c.114G>A	c.(112-114)agG>agA	p.R38R		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	38						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTACAATCTCCCTTTGCACTT	0.363000													25	88					0	0	1	0	0
CSN2	1447	broad.mit.edu	37	4	70823435	70823435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70823435G>A	ENST00000353151.3	-	5	243	c.232C>T	c.(232-234)Cca>Tca	p.P78S		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	78					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						ATGTTTTGTGGAAGAAAACCA	0.468000													29	111					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177036456	177036456	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:177036456G>A	ENST00000468418.3	+	4	2843	c.753G>A	c.(751-753)aaG>aaA	p.K251K	HOXD3_ENST00000249440.3_Silent_p.K251K|HOXD3_ENST00000410016.1_Silent_p.K251K			P31249	HXD3_HUMAN	homeobox D3	251					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGTACAAGAAGGACCAGAAGG	0.662000													37	89					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38903382	38903382	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38903382G>A	ENST00000359357.3	+	75	11075	c.10821G>A	c.(10819-10821)gaG>gaA	p.E3607E	RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Silent_p.E3824E|DNAH8_ENST00000441566.1_Silent_p.E3571E					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TAGAGGCTGAGAGGGTTAAAC	0.313000													93	200					0	0	1	0	0
TEKT3	64518	broad.mit.edu	37	17	15234464	15234464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:15234464C>T	ENST00000395930.1	-	3	625	c.439G>A	c.(439-441)Gga>Aga	p.G147R	TEKT3_ENST00000338696.2_Missense_Mutation_p.G147R	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3	147					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		ACACGTTCTCCCAGATTTTGG	0.388000													30	51					0	0	1	0	0
FCER2	2208	broad.mit.edu	37	19	7755310	7755310	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7755310G>A	ENST00000346664.5	-	9	815	c.603C>T	c.(601-603)atC>atT	p.I201I	FCER2_ENST00000360067.4_Silent_p.I200I|FCER2_ENST00000597921.1_Silent_p.I201I	NM_001220500.1|NM_002002.4	NP_001207429.1|NP_001993.2	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor for (CD23)	201	C-type lectin.				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10						CCGGGCTGTGGATGCTGACCA	0.637000													17	53					0	0	1	0	0
OR5P2	120065	broad.mit.edu	37	11	7817655	7817655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7817655G>A	ENST00000329434.2	-	1	865	c.835C>T	c.(835-837)Ccc>Tcc	p.P279S	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTCAACATGGGAATCACCACT	0.438000													30	107					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139151280	139151280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139151280C>T	ENST00000395297.1	-	18	4020	c.3850G>A	c.(3850-3852)Gat>Aat	p.D1284N		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1284										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCAGCATTATCCCTGAAGGTC	0.423000										HNSCC(54;0.14)			27	72					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210560616	210560616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:210560616C>T	ENST00000360351.4	+	7	4228	c.3722C>T	c.(3721-3723)gCc>gTc	p.A1241V	MAP2_ENST00000447185.1_Missense_Mutation_p.A1237V|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000392194.1_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1241					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GAGATAGAAGCCCAGGGAGAA	0.493000													8	56					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123283252	123283252	+	Silent	SNP	C	C	T	rs35817975		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123283252C>T	ENST00000264501.4	+	86	15241	c.14868C>T	c.(14866-14868)ggC>ggT	p.G4956G	KIAA1109_ENST00000388738.3_Silent_p.G4956G			Q2LD37	K1109_HUMAN	KIAA1109	4956					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AAAAATTGGGCTTTCATCATG	0.353000													29	166					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44114596	44114596	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44114596C>T	ENST00000259746.9	+	11	978	c.795C>T	c.(793-795)ccC>ccT	p.P265P	TMEM63B_ENST00000323267.6_Silent_p.P265P			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	265						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			AAGCCTACCCCAACTGCACAG	0.562000													33	70					0	0	1	0	0
C1QA	712	broad.mit.edu	37	1	22965719	22965719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22965719C>T	ENST00000374642.3	+	3	761	c.557C>T	c.(556-558)tCc>tTc	p.S186F	C1QA_ENST00000402322.1_Missense_Mutation_p.S186F	NM_015991.2	NP_057075.1	P02745	C1QA_HUMAN	complement component 1, q subcomponent, A chain	186	C1q.				cell-cell signaling|complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				autonomic_ganglia(1)|liver(1)|lung(3)|skin(1)	6		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.41e-27)|Colorectal(126;1.52e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.63e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000541)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GTCCGACGCTCCCTGGGCTTC	0.592000													14	63					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145627780	145627780	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:145627780G>A	ENST00000296575.3	+	5	1584	c.929G>A	c.(928-930)tGg>tAg	p.W310*		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	310						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		CAAGAACGGTGGGCTATCGGG	0.433000													16	35					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25349830	25349830	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25349830G>A	ENST00000546682.1	+	0	2300				SNHG14_ENST00000516123.1_RNA|SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						TGGAATCTGAGCAAAACGAGT	0.463000													20	88					0	0	1	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642706	1642706	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1642706G>A	ENST00000399682.1	-	1	662	c.618C>T	c.(616-618)tcC>tcT	p.S206S		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	266	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGCAGCAACTGGACTGGCAGC	0.597000													74	144					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221279	161221279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161221279G>A	ENST00000327928.4	+	4	983	c.983G>A	c.(982-984)cGg>cAg	p.R328Q		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	328	Collagen-like 3.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AAGGGCTCTCGGGGCTTTAAA	0.572000													7	16					0	0	1	0	0
APPL1	26060	broad.mit.edu	37	3	57272128	57272128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:57272128C>T	ENST00000288266.3	+	4	416	c.269C>T	c.(268-270)tCa>tTa	p.S90L		NM_012096.2	NP_036228.1	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	90	Required for RAB5A binding.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(10)|liver(2)|lung(4)|prostate(2)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		CAACAGTTTTCAAAAGTTATA	0.328000													19	45					0	0	1	0	0
SIAE	54414	broad.mit.edu	37	11	124530644	124530644	+	Silent	SNP	G	G	A	rs147638217		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124530644G>A	ENST00000263593.3	-	3	457	c.285C>T	c.(283-285)ttC>ttT	p.F95F	SIAE_ENST00000545756.1_Silent_p.F60F			Q9HAT2	SIAE_HUMAN	sialic acid acetylesterase	95						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	15	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		CCATCACTTCGAAAGGTCCTC	0.443000													80	183					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77407038	77407038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77407038G>A	ENST00000560626.2	-	7	5176	c.4701C>T	c.(4699-4701)gaC>gaT	p.D1567D	PEAK1_ENST00000312493.4_Silent_p.D1567D			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1567	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										GGATCTCGGGGTCCACCAGAT	0.537000													44	149					0	0	1	0	0
MKKS	8195	broad.mit.edu	37	20	10393713	10393713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:10393713G>A	ENST00000347364.2	-	3	1212	c.450C>T	c.(448-450)ctC>ctT	p.L150L		NM_170784.2	NP_740754.1	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome	150					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding			kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|stomach(2)	16						CCAAACAAAGGAGGATCTGAG	0.408000													34	83					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52475669	52475669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52475669C>T	ENST00000231721.2	-	6	587	c.588G>A	c.(586-588)ctG>ctA	p.L196L		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	196	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CCTCTCGCCCCAGGAAGTCAG	0.657000													6	78					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98763931	98763931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98763931G>A	ENST00000266058.4	-	34	4004	c.3759C>T	c.(3757-3759)gcC>gcT	p.A1253A	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.A1253A	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1253	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TCTGGTCAAAGGCAACCAGCT	0.557000													47	208					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124743205	124743205	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124743205G>A	ENST00000397801.1	+	10	1728		c.e10-1		ROBO3_ENST00000538940.1_Splice_Site	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)						axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTCTCTTCCAGGAGATGGACA	0.552000													9	10					0	0	1	0	0
MRPL51	51258	broad.mit.edu	37	12	6601548	6601548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6601548G>A	ENST00000229238.3	-	3	737	c.276C>T	c.(274-276)atC>atT	p.I92I	MRPL51_ENST00000543703.1_5'UTR|MRPL51_ENST00000543164.1_5'UTR	NM_016497.3	NP_057581.2	Q4U2R6	RM51_HUMAN	mitochondrial ribosomal protein L51	92					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome			kidney(2)|large_intestine(1)|lung(3)	6						TCCTCTTTCGGATACAACGTT	0.443000													88	283					0	0	1	0	0
METTL21C	196541	broad.mit.edu	37	13	103343261	103343261	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:103343261C>T	ENST00000267273.6	-	2	189	c.184G>A	c.(184-186)Gat>Aat	p.D62N		NM_001010977.1	NP_001010977.1	Q5VZV1	MT21C_HUMAN	methyltransferase like 21C	62							methyltransferase activity			breast(1)|large_intestine(3)|lung(2)|skin(1)	7						CTGGCGTAATCTGTAGGAACA	0.438000													8	104					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179664562	179664562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179664562C>T	ENST00000589042.1	-	5	883	c.659G>A	c.(658-660)cGa>cAa	p.R220Q	TTN_ENST00000342992.6_Missense_Mutation_p.R220Q|TTN_ENST00000360870.5_Missense_Mutation_p.R220Q|TTN_ENST00000460472.2_Missense_Mutation_p.R220Q|TTN_ENST00000342175.6_Missense_Mutation_p.R220Q|TTN_ENST00000359218.5_Missense_Mutation_p.R220Q|TTN_ENST00000591111.1_Missense_Mutation_p.R220Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	220							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R220P(6)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTTCAATTCGGGTTTGTCT	0.403000													22	47					0	0	1	0	0
PRKG1	5592	broad.mit.edu	37	10	54031199	54031199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:54031199C>T	ENST00000373980.4	+	11	1680	c.1263C>T	c.(1261-1263)atC>atT	p.I421I	PRKG1-AS1_ENST00000426785.2_RNA|PRKG1-AS1_ENST00000452247.2_RNA|PRKG1_ENST00000401604.2_Silent_p.I406I|PRKG1_ENST00000373975.2_Silent_p.I124I|PRKG1_ENST00000373985.1_Silent_p.I394I	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	406	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		AGGAGCACATCCGCTCAGAGA	0.463000													13	45					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213419	9213419	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9213419G>A	ENST00000305456.2	-	1	563	c.564C>T	c.(562-564)tcC>tcT	p.S188S		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						CTGTGCAGAAGGACAGCCTCA	0.493000													27	50					0	0	1	0	0
RNF186	54546	broad.mit.edu	37	1	20141286	20141286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20141286C>T	ENST00000375121.2	-	1	485	c.309G>A	c.(307-309)gaG>gaA	p.E103E	RP11-91K11.2_ENST00000454736.1_RNA	NM_019062.1	NP_061935.1	Q9NXI6	RN186_HUMAN	ring finger protein 186	103						integral to membrane	zinc ion binding			kidney(1)|lung(3)|urinary_tract(1)	5		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCACCGCCTCATGGTCGC	0.672000													15	71					0	0	1	0	0
ACVR1	90	broad.mit.edu	37	2	158634709	158634709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158634709G>A	ENST00000263640.3	-	5	906	c.477C>T	c.(475-477)ccC>ccT	p.P159P	ACVR1_ENST00000434821.1_Silent_p.P159P|ACVR1_ENST00000487456.1_5'UTR|ACVR1_ENST00000410057.2_Silent_p.P159P|ACVR1_ENST00000409283.2_Silent_p.P159P	NM_001105.4	NP_001096.1	Q04771	ACVR1_HUMAN	activin A receptor, type I	159					BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	19				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	CCACGTCTCGGGGATTGAGGC	0.483000													16	40					0	0	1	0	0
RNF14	9604	broad.mit.edu	37	5	141359747	141359747	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141359747C>A	ENST00000394520.2	+	6	1203	c.894C>A	c.(892-894)tcC>tcA	p.S298S	AC005740.5_ENST00000520882.1_RNA|RNF14_ENST00000356143.1_Silent_p.S298S|RNF14_ENST00000394515.3_Silent_p.S122S|RNF14_ENST00000394514.2_Silent_p.S172S|RNF14_ENST00000394519.1_Silent_p.S298S|RNF14_ENST00000540015.1_Intron|RNF14_ENST00000347642.3_Silent_p.S298S	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	298					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		TCCTCCAGTCCTCCTTGGACC	0.542000													41	185					2.24722e-20	2.26126e-20	1	1	0
PGLYRP3	114771	broad.mit.edu	37	1	153276337	153276337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153276337C>T	ENST00000290722.1	-	4	577	c.525G>A	c.(523-525)agG>agA	p.R175R		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	175					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCTTACCCTTCCTGGGCATCA	0.537000													29	72					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424154	125424154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125424154C>T	ENST00000373686.1	+	1	310	c.310C>T	c.(310-312)Cgt>Tgt	p.R104C				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						CTCAGACACTCGTCTCCAGAC	0.468000													45	95					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31606007	31606007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31606007C>T	ENST00000379416.3	-	11	946	c.898G>A	c.(898-900)Gga>Aga	p.G300R	XDH_ENST00000491727.1_5'UTR	NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	300	FAD-binding PCMH-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CAAGCAGCTCCAAAGGAGATA	0.522000													17	51					0	0	1	0	0
CA9	768	broad.mit.edu	37	9	35679199	35679199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35679199C>T	ENST00000378357.4	+	7	1029	c.925C>T	c.(925-927)Cca>Tca	p.P309S	CA9_ENST00000493245.1_3'UTR	NM_001216.2	NP_001207.2	Q16790	CAH9_HUMAN	carbonic anhydrase IX	309	Catalytic.				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	17	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GACTCAGGTCCCAGGACTGGA	0.537000													24	258					0	0	1	0	0
IL11RA	3590	broad.mit.edu	37	9	34660551	34660551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34660551C>T	ENST00000555003.1	+	11	2479	c.1123C>T	c.(1123-1125)Ctt>Ttt	p.L375F	IL11RA_ENST00000602473.1_Missense_Mutation_p.L375F|IL11RA_ENST00000441545.2_Missense_Mutation_p.L375F|IL11RA_ENST00000378817.4_Missense_Mutation_p.L375F|IL11RA_ENST00000318041.9_Missense_Mutation_p.L375F			Q14626	I11RA_HUMAN	interleukin 11 receptor, alpha	375						integral to plasma membrane	cytokine receptor activity			breast(1)|large_intestine(1)|ovary(1)|skin(1)	4	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.174)	Oprelvekin(DB00038)	TTTGGGAATCCTTTCTTTCCT	0.592000													11	36					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20296056	20296056	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20296056T>C	ENST00000315947.1	+	1	449	c.449T>C	c.(448-450)cTt>cCt	p.L150P	OR4N2_ENST00000568211.1_Missense_Mutation_p.L150P	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTCTGTGGCTTGGGGGTTTT	0.532000													73	153					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28647982	28647982	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28647982C>T	ENST00000280904.6	-	16	3148	c.2705G>A	c.(2704-2706)tGa>tAa	p.*902*	DSC2_ENST00000251081.6_3'UTR	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	0					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			AGAACACACTCATCTCTTCAT	0.373000													9	47					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197446859	197446859	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197446859G>A	ENST00000367400.3	+	12	4206	c.4071G>A	c.(4069-4071)ctG>ctA	p.L1357L	CRB1_ENST00000535699.1_Silent_p.L1333L|CRB1_ENST00000538660.1_Silent_p.L821L|CRB1_ENST00000544212.1_Silent_p.L838L|CRB1_ENST00000367399.2_Silent_p.L1245L	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1357					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCTTGTTACTGATCCTCTTGC	0.502000													10	53					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28362215	28362215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28362215G>A	ENST00000261609.7	-	87	13466	c.13358C>T	c.(13357-13359)tCg>tTg	p.S4453L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4453					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GGGACCAAACGAGCTCATCTT	0.592000													5	40					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110476877	110476877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110476877G>A	ENST00000378402.5	+	49	7920	c.7816G>A	c.(7816-7818)Gtt>Att	p.V2606I		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2606					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCAAAAAAGAGTTCCCCTTGG	0.438000										HNSCC(38;0.096)			13	95					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51728689	51728689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51728689G>A	ENST00000262262.4	+	2	274	c.253G>A	c.(253-255)Gag>Aag	p.E85K	CD33_ENST00000421133.2_Intron|CD33_ENST00000436584.2_Intron|CD33_ENST00000391796.3_Missense_Mutation_p.E85K	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	85	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AGTACAGGAGGAGACTCAGGG	0.522000													26	96					0	0	1	0	0
ERO1L	30001	broad.mit.edu	37	14	53149110	53149110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:53149110G>A	ENST00000395686.3	-	3	474	c.251C>T	c.(250-252)cCg>cTg	p.P84L		NM_014584.1	NP_055399.1	Q96HE7	ERO1A_HUMAN	ERO1-like (S. cerevisiae)	84					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor		ERO1L/FERMT2(2)	breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12	Breast(41;0.226)					GAAAGGACACGGCCTCTTCAG	0.333000													35	106					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57641207	57641207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57641207G>A	ENST00000254181.4	+	4	1618	c.1164G>A	c.(1162-1164)atG>atA	p.M388I	USP29_ENST00000598197.1_Missense_Mutation_p.M388I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	388					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAGAAGACATGGAAAAATTAA	0.378000													34	75					0	0	1	0	0
FOXI2	399823	broad.mit.edu	37	10	129536979	129536979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129536979C>T	ENST00000388920.4	+	2	746	c.707C>T	c.(706-708)cCa>cTa	p.P236L		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	236					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				TCGCCCTCTCCATCCGCACCC	0.751000													4	16					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55048253	55048253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55048253G>A	ENST00000335056.3	+	5	858	c.820G>A	c.(820-822)Gaa>Aaa	p.E274K	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GAGACACAGGGAAGCATTCCA	0.547000													44	100					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	514923	514923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:514923C>T	ENST00000453061.2	+	7	1299	c.1193C>T	c.(1192-1194)tCa>tTa	p.S398L	PIGG_ENST00000383028.4_Missense_Mutation_p.S265L|PIGG_ENST00000536264.1_Missense_Mutation_p.S276L|PIGG_ENST00000509768.1_Missense_Mutation_p.S309L|PIGG_ENST00000503111.1_Intron|PIGG_ENST00000296306.7_Intron|PIGG_ENST00000310340.5_Missense_Mutation_p.S398L|PIGG_ENST00000504346.1_Missense_Mutation_p.S309L	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	398					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						GAAAAGCATTCAGAAGTCCTA	0.473000													33	87					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128651888	128651888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128651888G>A	ENST00000344954.6	+	5	914	c.526G>A	c.(526-528)Gac>Aac	p.D176N	FLI1_ENST00000429175.2_Missense_Mutation_p.D209N|FLI1_ENST00000534087.1_Missense_Mutation_p.D176N|FLI1_ENST00000281428.8_Missense_Mutation_p.D143N|FLI1_ENST00000525560.1_Missense_Mutation_p.D16N			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	209	PNT.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		CTCCCACACCGACCAATCCTC	0.413000			T	EWSR1	Ewing sarcoma								34	89					0	0	1	0	0
CD81	975	broad.mit.edu	37	11	2415372	2415372	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2415372T>G	ENST00000263645.5	+	3	485	c.229T>G	c.(229-231)Ttc>Gtc	p.F77V	CD81_ENST00000524805.1_3'UTR|CD81_ENST00000492627.1_Missense_Mutation_p.F6V|CD81_ENST00000526072.1_Missense_Mutation_p.F6V|CD81_ENST00000481687.1_Missense_Mutation_p.F83V|CD81_ENST00000381036.3_Missense_Mutation_p.F115V	NM_004356.3	NP_004347.1	P60033	CD81_HUMAN	CD81 molecule	77					activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding			endometrium(1)|lung(3)|skin(1)	5		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTTCGTTGGCTTCCTGGGCTG	0.662000													18	47					0	0	1	0	0
ATP13A4	84239	broad.mit.edu	37	3	193120444	193120444	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:193120444G>A	ENST00000342695.4	-	30	3910	c.3588C>T	c.(3586-3588)ctC>ctT	p.L1196L	ATP13A4_ENST00000392443.3_Silent_p.L1177L|ATP13A4_ENST00000400270.2_Silent_p.L212L|ATP13A4_ENST00000482964.1_5'UTR	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1196					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		ATGTCCTTCAGAGTTGTTCTT	0.433000													24	27					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207785317	207785317	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207785317C>T	ENST00000367049.4	+	39	6506	c.6506C>T	c.(6505-6507)cCt>cTt	p.P2169L	CR1_ENST00000367052.1_Missense_Mutation_p.P1719L|CR1_ENST00000367051.1_Missense_Mutation_p.P1719L|CR1_ENST00000400960.2_Missense_Mutation_p.P1719L|CR1_ENST00000367053.1_Missense_Mutation_p.P1719L	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1719					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity	p.P2169L(1)|p.P1724L(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GGCCAACTCCCTCATGGCCGT	0.483000													30	408					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41710281	41710281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41710281C>T	ENST00000400454.1	-	8	2007	c.1530G>A	c.(1528-1530)atG>atA	p.M510I		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	510	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGATGTTTTTCATTGGTCGAA	0.418000													13	52					0	0	1	0	0
URAD	646625	broad.mit.edu	37	13	28562602	28562602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28562602G>A	ENST00000332715.4	-	1	172	c.173C>T	c.(172-174)tCa>tTa	p.S58L		NM_001105577.1	NP_001099047.1			ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase																		AGCCTTACCTGACTGTGCAAG	0.433000													18	45					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239010666	239010666	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239010666G>A	ENST00000343063.3	+	2	642	c.379G>A	c.(379-381)Ggc>Agc	p.G127S	ESPNL_ENST00000409169.1_Missense_Mutation_p.G127S	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	127										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GCTCCACGAGGGCCACTCGGC	0.701000													3	17					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739539	55739539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55739539C>T	ENST00000370830.3	-	1	823	c.125G>A	c.(124-126)aGa>aAa	p.R42K	BMP5_ENST00000446683.2_Missense_Mutation_p.R42K	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	42					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GTTCCGTAGTCTTCTATAAAT	0.453000													62	173					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105207212	105207212	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105207212C>T	ENST00000332972.5	+	7	909	c.750C>T	c.(748-750)ttC>ttT	p.F250F	ADSSL1_ENST00000330877.2_Silent_p.F207F	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	207					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	AGTCGATGTTCCCCACCCTGG	0.602000													17	294					0	0	1	0	0
CENPH	64946	broad.mit.edu	37	5	68492933	68492933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:68492933C>T	ENST00000283006.2	+	5	455	c.368C>T	c.(367-369)tCt>tTt	p.S123F	CENPH_ENST00000515001.1_Intron	NM_022909.3	NP_075060.1	Q9H3R5	CENPH_HUMAN	centromere protein H	123					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|kinetochore organization|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	kinetochore binding|protein binding			kidney(15)|large_intestine(2)|lung(3)	20		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.41e-56)|Epithelial(20;1.29e-52)|all cancers(19;3.15e-48)|Lung(70;0.0178)		AGCAGACAGTCTAGGTATGAT	0.328000													14	55					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15580492	15580492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15580492G>A	ENST00000292609.4	-	4	1721	c.1592C>T	c.(1591-1593)cCc>cTc	p.P531L	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.P531L			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	531					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						CGCGTCGCCGGGGCAGTCGGT	0.726000													5	12					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49825032	49825032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:49825032C>T	ENST00000451037.2	-	4	1366	c.426G>A	c.(424-426)ggG>ggA	p.G142G	CA10_ENST00000570565.1_Silent_p.G67G|CA10_ENST00000571918.1_5'UTR|CA10_ENST00000442502.2_Silent_p.G142G|CA10_ENST00000285273.4_Silent_p.G142G|CA10_ENST00000340813.6_Silent_p.G148G	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	142					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GGTGCTCCGACCCTTGGCTGT	0.507000													57	131					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202446915	202446915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202446915C>T	ENST00000439140.1	-	5	586	c.542G>A	c.(541-543)cGg>cAg	p.R181Q	ALS2CR11_ENST00000450242.1_Missense_Mutation_p.R181Q|ALS2CR11_ENST00000439802.1_Missense_Mutation_p.R181Q|ALS2CR11_ENST00000286195.3_Missense_Mutation_p.R181Q	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	181										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						AATATTATTCCGCTTATCATC	0.303000													21	89					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11650885	11650885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11650885G>A	ENST00000262442.3	+	32	6480	c.6412G>A	c.(6412-6414)Gag>Aag	p.E2138K	DNAH9_ENST00000454412.2_Missense_Mutation_p.E2138K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2138	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGTCCAGCTGGAGGAGCTCCT	0.582000													15	12					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62995958	62995958	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62995958T>G	ENST00000306494.6	-	2	480	c.481A>C	c.(481-483)Aac>Cac	p.N161H	SLC22A25_ENST00000403374.2_5'UTR|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	161					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CCATATAGGTTGCCTCCCACC	0.408000													25	66					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43865643	43865643	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43865643C>T	ENST00000378009.4	+	0	1154				CTC-490G23.4_ENST00000607109.1_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				GTGTGCAGCCCCTTGGAACCT	0.602000													9	69					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33623141	33623141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33623141C>T	ENST00000361680.2	+	1	144	c.66C>T	c.(64-66)tcC>tcT	p.S22S	WDR88_ENST00000592765.1_Silent_p.S22S|WDR88_ENST00000355868.3_Silent_p.S22S			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	22										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					CGCCACCCTCCGCCCCCGCCA	0.701000													8	72					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106208133	106208133	+	RNA	SNP	C	C	T	rs1803800		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106208133C>T	ENST00000390548.2	-	0	670																											CGGGGCTGCCCTGTAGGGACA	0.642000													59	178					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207870911	207870911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207870911C>T	ENST00000508064.2	+	6	986	c.926C>T	c.(925-927)tCa>tTa	p.S309L	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	309	Sushi 5.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GACAACTTTTCACCCGGGCAG	0.547000													69	200					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29039024	29039024	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29039024G>A	ENST00000257189.4	+	5	484	c.401G>A	c.(400-402)gGa>gAa	p.G134E		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	134	Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AATGCCCAAGGACTAGATGTA	0.328000													21	39					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29414516	29414516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:29414516G>A	ENST00000378993.1	+	4	1177	c.504G>A	c.(502-504)gaG>gaA	p.E168E	IL1RAPL1_ENST00000302196.4_Silent_p.E168E	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	168	Ig-like C2-type 2.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						GTGACATAGAGGATTTTCTAC	0.378000													58	49					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921362	24921362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24921362C>T	ENST00000329468.2	+	1	822	c.348C>T	c.(346-348)atC>atT	p.I116I		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCGTAAGGATCCCTCCTCCCA	0.657000													28	57					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20071504	20071504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20071504G>A	ENST00000245957.5	+	7	659	c.583G>A	c.(583-585)Gat>Aat	p.D195N	C20orf26_ENST00000451767.2_Missense_Mutation_p.D195N|C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000377306.1_Missense_Mutation_p.D195N|C20orf26_ENST00000377309.2_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	195								p.D195N(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		AGACCATGACGATCTCATGCC	0.438000													36	197					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32332505	32332505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32332505G>A	ENST00000298386.2	+	2	276	c.205G>A	c.(205-207)Gat>Aat	p.D69N	RXFP2_ENST00000380314.1_Missense_Mutation_p.D69N	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	69	LDL-receptor class A.					integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TGATGGCAAGGATGACTGTGG	0.522000													46	129					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36580097	36580097	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:36580097C>T	ENST00000431169.1	-	16	1434	c.1133_splice	c.e16-1	p.G378_splice	AOAH_ENST00000258749.5_Splice_Site_p.G378_splice|AOAH_ENST00000535891.1_Splice_Site_p.G346_splice|AOAH_ENST00000491444.1_5'UTR|AOAH_ENST00000538464.1_Splice_Site_p.G100_splice	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	378					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity	p.G378G(1)		NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GGTCACTCTTCCTGTTGGTGG	0.463000													16	46					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52374652	52374652	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52374652C>T	ENST00000296585.5	+	24	3019	c.2876C>T	c.(2875-2877)tCa>tTa	p.S959L		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	959					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AATGTTCCTTCAATCGTGCAC	0.373000													17	42					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32259377	32259377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32259377C>T	ENST00000360482.2	-	12	2634	c.2505G>A	c.(2503-2505)agG>agA	p.R835R	SPOCD1_ENST00000257100.3_Silent_p.R328R|SPOCD1_ENST00000373648.2_3'UTR|SPOCD1_ENST00000533231.1_Silent_p.R835R	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	835					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GAGACAACTCCCTGGTTTTGG	0.592000													74	112					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45281205	45281205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45281205C>T	ENST00000270279.3	+	1	80	c.17C>T	c.(16-18)gCc>gTc	p.A6V	CBLC_ENST00000341505.4_Missense_Mutation_p.A6V	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	6					cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				CTGGCGGTGGCCCCGTGGGGG	0.716000			M		AML								9	15					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23830128	23830128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:23830128C>T	ENST00000264867.2	-	5	771	c.652G>A	c.(652-654)Gat>Aat	p.D218N	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	218					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GGAGGGTCATCGTTTGTGGTC	0.468000													54	170					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130290201	130290201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130290201G>A	ENST00000358511.6	+	6	2972	c.2941G>A	c.(2941-2943)Gat>Aat	p.D981N	COL6A6_ENST00000453409.2_Missense_Mutation_p.D981N	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	981	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AATATTTTCAGATGTGACAGC	0.433000													13	28					0	0	1	0	0
WNT8B	7479	broad.mit.edu	37	10	102240871	102240871	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102240871G>A	ENST00000343737.5	+	4	486	c.358G>A	c.(358-360)Ggg>Agg	p.G120R		NM_003393.3	NP_003384.2	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family, member 8B	120					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|large_intestine(1)|ovary(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		CTCCCGCAACGGGCAACTGGG	0.488000													30	53					0	0	1	0	0
WDR35	57539	broad.mit.edu	37	2	20169345	20169345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:20169345G>A	ENST00000345530.3	-	9	1019	c.904C>T	c.(904-906)Cct>Tct	p.P302S	WDR35_ENST00000416055.2_5'UTR|WDR35_ENST00000281405.4_Missense_Mutation_p.P302S	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	302										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTTTCCAGGAACTTTCAAA	0.338000													26	50					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8122528	8122528	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8122528C>T	ENST00000305253.4	+	12	1777	c.1536C>T	c.(1534-1536)atC>atT	p.I512I	TUB_ENST00000534099.1_Silent_p.I463I|TUB_ENST00000299506.2_Silent_p.I457I	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	457					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		ACTTCCAGATCATCCATGGCA	0.522000													18	76					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41542137	41542137	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41542137G>A	ENST00000396942.1	-	37	4545	c.4462C>T	c.(4462-4464)Cga>Tga	p.R1488*	ANK1_ENST00000352337.4_Nonsense_Mutation_p.R1488*|ANK1_ENST00000396945.1_Nonsense_Mutation_p.R1488*|ANK1_ENST00000289734.7_Nonsense_Mutation_p.R1488*|ANK1_ENST00000379758.2_Nonsense_Mutation_p.R1488*|ANK1_ENST00000265709.8_Nonsense_Mutation_p.R1529*|ANK1_ENST00000347528.4_Nonsense_Mutation_p.R1488*			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1488	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CGGCTCTGTCGGCCGGAACCC	0.592000													14	40					0	0	1	0	0
SLC39A3	29985	broad.mit.edu	37	19	2733206	2733206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2733206G>A	ENST00000269740.4	-	3	817	c.488C>T	c.(487-489)tCg>tTg	p.S163L	SLC39A3_ENST00000545664.1_Missense_Mutation_p.S163L|AC006538.4_ENST00000586572.1_Intron	NM_144564.4	NP_653165.2	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter), member 3	163						integral to membrane|plasma membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGCGCGCGAGAGGCCCTG	0.731000													15	35					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55863771	55863771	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55863771G>A	ENST00000388975.3	-	10	1250	c.1134C>T	c.(1132-1134)ttC>ttT	p.F378F		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	378					cell cycle|cell division	septin complex	GTP binding|protein binding	p.F378F(1)|p.F167F(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TAAGATGCTCGAACTTGTCCT	0.378000													15	33					0	0	1	0	0
RSBN1L	222194	broad.mit.edu	37	7	77402549	77402549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:77402549C>T	ENST00000334955.7	+	6	1738	c.1711C>T	c.(1711-1713)Cat>Tat	p.H571Y	RSBN1L_ENST00000445288.1_Missense_Mutation_p.H301Y	NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	571						nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GACAAGAGCTCATGCAGATCA	0.423000													28	66					0	0	1	0	0
MIR498	574460	broad.mit.edu	37	19	54177468	54177468	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54177468G>A	ENST00000385134.1	+	0	18					NR_030182.1																						CTTGGGAAGTGAAGCTCAGGC	0.478000													39	99					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36109295	36109295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36109295C>T	ENST00000303965.4	-	27	4666	c.4177G>A	c.(4177-4179)Gaa>Aaa	p.E1393K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1393	Ras-associating.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGTACATTTTCCTTGTAGTGA	0.343000													43	99					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27703021	27703021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27703021G>A	ENST00000438700.3	-	1	276	c.159C>T	c.(157-159)tcC>tcT	p.S53S		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	53					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						AGGGTTCGGGGGATTTCGGGG	0.697000													36	84					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56587632	56587632	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56587632C>T	ENST00000336078.4	+	4	2889	c.2113C>T	c.(2113-2115)Ctt>Ttt	p.L705F	ZNF532_ENST00000591083.1_Missense_Mutation_p.L705F|ZNF532_ENST00000591808.1_Missense_Mutation_p.L705F|ZNF532_ENST00000589288.1_Missense_Mutation_p.L705F|ZNF532_ENST00000591230.1_Missense_Mutation_p.L705F	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						AACTTCCACTCTTCAGAGCCC	0.483000													6	92					0	0	1	0	0
ZNF556	80032	broad.mit.edu	37	19	2877393	2877393	+	Missense_Mutation	SNP	G	G	A	rs35499960	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2877393G>A	ENST00000586426.1	+	4	521	c.434G>A	c.(433-435)cGg>cAg	p.R145Q	ZNF556_ENST00000307635.2_Missense_Mutation_p.R146Q			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTGTAAGACGGTACGAATGC	0.393000													37	110					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29675075	29675075	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29675075G>A	ENST00000431530.3	+	3	2700	c.2642G>A	c.(2641-2643)aGt>aAt	p.S881N		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	871	Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.|Sufficient for interaction with KIF2C.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TCCGGGGACAGTGCACAGCCA	0.642000													6	10					0	0	1	0	0
IGHV3-66	28412	broad.mit.edu	37	14	107131135	107131135	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107131135C>T	ENST00000390632.2	-	0	324																											ATCGGCCCTTCACGGAGTCTG	0.522000													15	165					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136320418	136320418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136320418C>T	ENST00000371929.3	+	25	3705	c.3261C>T	c.(3259-3261)tcC>tcT	p.S1087S	ADAMTS13_ENST00000356589.2_Silent_p.S1056S|ADAMTS13_ENST00000485925.1_3'UTR|ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000355699.2_Silent_p.S1087S	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	1087	TSP type-1 8.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GCTCTGTTTCCTGTGGGGATG	0.617000													20	167					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142561799	142561799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142561799C>T	ENST00000392957.2	+	7	1028	c.241C>T	c.(241-243)Cct>Tct	p.P81S	EPHB6_ENST00000442129.1_Missense_Mutation_p.P81S|EPHB6_ENST00000411471.2_Intron	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	81						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GGCAGGGGCCCCTCCAGGCAC	0.632000													77	202					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389390	4389390	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4389390G>A	ENST00000408920.2	-	1	226	c.136C>T	c.(136-138)Ctg>Ttg	p.L46L		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGATGAGCAGGCTGTTCCCA	0.527000													13	27					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104493142	104493142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104493142G>A	ENST00000409874.4	+	28	3196	c.3148G>A	c.(3148-3150)Gtc>Atc	p.V1050I	TDRD9_ENST00000339063.5_Missense_Mutation_p.V1050I	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	1050					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				CCTTGTGAAGGTCTTCTCTGT	0.572000													23	58					0	0	1	0	0
CNDP1	84735	broad.mit.edu	37	18	72238431	72238431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:72238431G>A	ENST00000582365.1	+	6	704	c.638G>A	c.(637-639)aGa>aAa	p.R213K	CNDP1_ENST00000358821.3_Missense_Mutation_p.R256K			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)	256					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GTGAAATGCAGAGACCAGGAT	0.413000													28	90					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8755350	8755350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:8755350G>A	ENST00000378641.3	+	27	3570	c.3095G>A	c.(3094-3096)cGa>cAa	p.R1032Q	PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Missense_Mutation_p.R1032Q|PLCB1_ENST00000338037.6_Missense_Mutation_p.R1032Q	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1032					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TACCAGAAGCGAGAACATATT	0.373000													25	74					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74429817	74429817	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74429817G>A	ENST00000376332.3	-	2	639	c.143C>T	c.(142-144)cCc>cTc	p.P48L	CHRDL2_ENST00000263671.5_Missense_Mutation_p.P48L|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	48	VWFC 1.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					CTCCAAGTAGGGGTGCCAGCT	0.587000													7	25					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2893767	2893767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:2893767G>A	ENST00000380698.4	-	5	534	c.445C>T	c.(445-447)Ccg>Tcg	p.P149S		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	149					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GAGCTACCCGGCAACAACTCT	0.398000													41	102					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453654	84453654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:84453654G>A	ENST00000377084.2	-	1	2874	c.1989C>T	c.(1987-1989)tcC>tcT	p.S663S		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	663						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTGTCTGTAGGGAATTAATCT	0.557000													5	34					0	0	1	0	0
MISP	126353	broad.mit.edu	37	19	757826	757826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:757826G>A	ENST00000215582.6	+	2	983	c.880G>A	c.(880-882)Gag>Aag	p.E294K		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GACGCCCATCGAGCGGGAGAT	0.667000													9	66					0	0	1	0	0
XPO4	64328	broad.mit.edu	37	13	21396000	21396000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:21396000G>A	ENST00000400602.2	-	9	1051	c.1016C>T	c.(1015-1017)tCt>tTt	p.S339F	XPO4_ENST00000255305.6_Missense_Mutation_p.S339F	NM_022459.4	NP_071904.4	Q9C0E2	XPO4_HUMAN	exportin 4	339					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		CACAGCTTCAGAATCTTCTAT	0.338000													17	45					0	0	1	0	0
GYPA	2993	broad.mit.edu	37	4	145039905	145039905	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:145039905C>T	ENST00000360771.4	-	4	348	c.232_splice	c.e4-1	p.G78_splice	GYPA_ENST00000504786.1_Splice_Site_p.G46_splice|GYPA_ENST00000503627.1_Intron|GYPB_ENST00000283126.7_Intron|GYPA_ENST00000324022.10_Splice_Site_p.G45_splice|GYPA_ENST00000535709.1_Splice_Site_p.G52_splice|GYPA_ENST00000512789.1_Splice_Site_p.G13_splice|GYPA_ENST00000512064.1_Intron|RP11-673E1.4_ENST00000506982.1_RNA	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	78			G -> R (in ERIK antigen; dbSNP:rs1800582).		interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					TACCCTTTCTCCTATAAAGCA	0.318000													26	74					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55277720	55277720	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55277720G>A	ENST00000358193.3	+	6	674	c.618_splice	c.e6-1	p.G207_splice	C1orf177_ENST00000371273.3_Splice_Site_p.G207_splice	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	207										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						GTGCTCTAGGGGAGTGGTCTG	0.627000													25	119					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94486955	94486955	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:94486955G>A	ENST00000375708.3	-	9	2019	c.1821C>T	c.(1819-1821)tcC>tcT	p.S607S	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Silent_p.S467S	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	607	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CGTGGTGGCTGGATAGGTACT	0.607000													23	51					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140615524	140615524	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140615524C>T	ENST00000526308.1	+	0	1587					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						ACAACAGCCCCGCCCTGCACA	0.637000													87	275					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123516367	123516367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123516367C>T	ENST00000392770.2	-	2	949	c.147G>A	c.(145-147)atG>atA	p.M49I	SCN3B_ENST00000530277.1_Missense_Mutation_p.M49I|SCN3B_ENST00000299333.3_Missense_Mutation_p.M49I	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	49	Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		CCTCTCTCTTCATGCAGGAGA	0.577000													27	133					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114278641	114278641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114278641C>T	ENST00000357077.4	+	38	8920	c.8867C>T	c.(8866-8868)tCt>tTt	p.S2956F	ANK2_ENST00000264366.6_Missense_Mutation_p.S2923F|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2923					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGTTTTCACTCTTCTGAAGTG	0.393000													56	245					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56373451	56373451	+	Silent	SNP	G	G	A	rs148970920		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56373451G>A	ENST00000301295.6	+	5	2534	c.2112G>A	c.(2110-2112)acG>acA	p.T704T	NLRP4_ENST00000346986.5_Silent_p.T704T|NLRP4_ENST00000587891.1_Silent_p.T629T	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	704							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCACCCTCACGAAACTCTCTC	0.463000													45	94					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48331680	48331680	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:48331680G>A	ENST00000428869.2	-	6	531	c.273C>T	c.(271-273)ctC>ctT	p.L91L	MRO_ENST00000398439.3_Silent_p.L91L|MRO_ENST00000587291.1_5'UTR|MRO_ENST00000431965.2_Silent_p.L105L|MRO_ENST00000436348.2_Silent_p.L105L|MRO_ENST00000256425.2_Silent_p.L91L|MRO_ENST00000588444.1_Silent_p.L91L			Q9BYG7	MSTRO_HUMAN	maestro	91						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		CCAGCAGGTCGAGGACAATTT	0.463000													15	91					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179622401	179622401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179622401C>T	ENST00000589042.1	-	45	10770	c.10546G>A	c.(10546-10548)Gag>Aag	p.E3516K	TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Missense_Mutation_p.E3470K|TTN_ENST00000591111.1_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3197	Ig-like 21.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGACTCCTCAAAATGGAAA	0.453000													35	96					0	0	1	0	0
ZNF623	9831	broad.mit.edu	37	8	144732203	144732203	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144732203C>T	ENST00000501748.2	+	1	250	c.161C>T	c.(160-162)cCc>cTc	p.P54L	ZNF623_ENST00000458270.2_Missense_Mutation_p.P14L|ZNF623_ENST00000526926.1_Missense_Mutation_p.P14L	NM_014789.3	NP_055604.3	O75123	ZN623_HUMAN	zinc finger protein 623	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GTCCACGAGCCCAGATTAGGG	0.567000													20	56					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130409647	130409647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130409647C>T	ENST00000370904.1	-	22	3872	c.2962G>A	c.(2962-2964)Gga>Aga	p.G988R	IGSF1_ENST00000370903.3_Missense_Mutation_p.G1002R|IGSF1_ENST00000370910.1_Missense_Mutation_p.G988R|IGSF1_ENST00000361420.3_Missense_Mutation_p.G997R			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	997	Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TATCCTACTCCATGGACCGGC	0.517000													52	31					0	0	1	0	0
DYDC2	84332	broad.mit.edu	37	10	82122265	82122265	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:82122265G>A	ENST00000372199.1	+	4	664	c.66G>A	c.(64-66)gcG>gcA	p.A22A	DYDC2_ENST00000372198.1_Silent_p.A36A|DYDC2_ENST00000444807.2_Silent_p.A22A|DYDC2_ENST00000372197.1_Silent_p.A22A|DYDC2_ENST00000256039.2_Silent_p.A22A			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	22							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			CAGAGGTGGCGAAGGTTCGGC	0.488000													24	52					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540736	94540736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94540736G>A	ENST00000289495.5	+	1	1527	c.1311G>A	c.(1309-1311)atG>atA	p.M437I	PPP1R9A_ENST00000340694.4_Missense_Mutation_p.M437I|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.M437I|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.M437I|PPP1R9A_ENST00000433881.1_Missense_Mutation_p.M437I|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.M437I	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	437	Interacts with protein phosphatase 1 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGCCTGATATGGAGTACTCGG	0.418000										HNSCC(28;0.073)			16	39					0	0	1	0	0
LCMT1	51451	broad.mit.edu	37	16	25151534	25151534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:25151534C>T	ENST00000399069.3	+	4	525	c.370C>T	c.(370-372)Cca>Tca	p.P124S	LCMT1_ENST00000380966.4_Missense_Mutation_p.P124S	NM_016309.2	NP_057393.2	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1	124							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity								GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	GGTTGACTTTCCAATGATTGT	0.403000													5	9					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104642395	104642395	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104642395C>T	ENST00000315264.7	+	11	3231	c.2853C>T	c.(2851-2853)gcC>gcT	p.A951A	KIF26A_ENST00000423312.2_Silent_p.A1090A			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1090					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCTCTCAGGCCCCTGAGGGGG	0.672000													7	12					0	0	1	0	0
C4B	721	broad.mit.edu	37	6	31997551	31997551	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31997551C>T	ENST00000435363.2	+	29	3969	c.3885C>T	c.(3883-3885)ttC>ttT	p.F1295F	C4B_ENST00000425700.2_Silent_p.F1295F	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1295					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										AGGGCAGCTTCCAAGGGGGAT	0.642000													14	66					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	15977991	15977991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:15977991G>A	ENST00000262101.5	-	9	1279	c.1158C>T	c.(1156-1158)gtC>gtT	p.V386V	MSR1_ENST00000445506.2_Silent_p.V404V|MSR1_ENST00000350896.3_Intron|MSR1_ENST00000355282.2_Intron			P21757	MSRE_HUMAN	macrophage scavenger receptor 1	386	SRCR.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TCCTACAGACGACCTGTCCAA	0.542000													50	115					0	0	1	0	0
SSX5	6758	broad.mit.edu	37	X	48047090	48047090	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48047090C>T	ENST00000311798.1	-	8	719	c.667G>A	c.(667-669)Gac>Aac	p.D223N	SSX5_ENST00000347757.1_Missense_Mutation_p.D182N|SSX5_ENST00000376923.1_Missense_Mutation_p.D182N	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						TCCTGAGGGTCGCTGATCTCT	0.483000													114	114					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123332988	123332988	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123332988C>T	ENST00000360772.3	-	34	5934	c.5556G>A	c.(5554-5556)gaG>gaA	p.E1852E	MYLK_ENST00000418370.2_Silent_p.E143E|MYLK-AS1_ENST00000463408.1_RNA|MYLK_ENST00000346322.5_Silent_p.E1834E|MYLK_ENST00000578202.1_Silent_p.E142E|MYLK_ENST00000360304.3_Silent_p.E1903E|MYLK-AS1_ENST00000470449.1_RNA|MYLK_ENST00000583087.1_Silent_p.E143E|MYLK_ENST00000475616.1_Silent_p.E1903E|MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000354792.5_Silent_p.E703E|MYLK_ENST00000359169.1_Silent_p.E1852E			Q15746	MYLK_HUMAN	myosin light chain kinase	1903	Ig-like C2-type 9.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CTTCACCTTCCTCCATCGTTT	0.458000													32	292					0	0	1	0	0
OGFRL1	79627	broad.mit.edu	37	6	72006513	72006513	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:72006513C>T	ENST00000370435.4	+	6	819	c.685C>T	c.(685-687)Ctg>Ttg	p.L229L	RP11-154D6.1_ENST00000423255.1_RNA|RP11-154D6.1_ENST00000587253.1_RNA|RP11-154D6.1_ENST00000586030.1_RNA|RP11-154D6.1_ENST00000432050.1_RNA|RP11-154D6.1_ENST00000591156.1_RNA|RP11-154D6.1_ENST00000586232.1_RNA|RP3-331H24.5_ENST00000602823.1_lincRNA|RP11-154D6.1_ENST00000412751.1_RNA|RP11-154D6.1_ENST00000588612.1_RNA	NM_024576.3	NP_078852.3	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	229						membrane	receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|upper_aerodigestive_tract(1)	13						ATTTCAGCATCTGAATGAGTA	0.408000													6	64					0	0	1	0	0
WNT3	7473	broad.mit.edu	37	17	44851147	44851147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:44851147G>A	ENST00000225512.5	-	2	371	c.209C>T	c.(208-210)gCc>gTc	p.A70V		NM_030753.4	NP_110380.1	P56703	WNT3_HUMAN	wingless-type MMTV integration site family, member 3	70					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			endometrium(2)|large_intestine(6)|lung(4)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(9;0.0257)			CACGCCCTCGGCCACGCTGGG	0.647000													28	36					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107097124	107097124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:107097124G>A	ENST00000261058.1	+	1	937	c.690G>A	c.(688-690)agG>agA	p.R230R		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	230										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						ATGCATCAAGGAGCTTTGAAA	0.368000													54	122					0	0	1	0	0
GTF2F2	2963	broad.mit.edu	37	13	45725907	45725907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:45725907C>T	ENST00000340473.6	+	4	386	c.245C>T	c.(244-246)cCa>cTa	p.P82L		NM_004128.2	NP_004119.1	P13984	T2FB_HUMAN	general transcription factor IIF, polypeptide 2, 30kDa	82					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	microtubule cytoskeleton|transcription factor TFIIF complex	ATP binding|ATP-dependent helicase activity|DNA binding|protein binding			breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|prostate(1)|upper_aerodigestive_tract(1)	10		Lung NSC(96;0.00115)|Prostate(109;0.00578)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000647)		AGAGAACATCCATTTGTCTTG	0.368000													60	161					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400585	89400585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89400585C>T	ENST00000439576.2	+	12	5143	c.4769C>T	c.(4768-4770)cCt>cTt	p.P1590L	ACAN_ENST00000559004.1_Missense_Mutation_p.P1590L|ACAN_ENST00000561243.1_Missense_Mutation_p.P1590L|ACAN_ENST00000352105.7_Missense_Mutation_p.P1590L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1590					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGTGGGTTGCCTTCTGGAAAA	0.532000													15	154					0	0	1	0	0
CEACAM21	90273	broad.mit.edu	37	19	42090779	42090779	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42090779C>T	ENST00000407170.2	+	5	1209	c.396C>T	c.(394-396)ctC>ctT	p.L132L	CEACAM21_ENST00000401445.2_Silent_p.L260L|CEACAM21_ENST00000482870.2_3'UTR|CEACAM21_ENST00000187608.9_Silent_p.L259L			Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	260						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						GTTTCCTGCTCCTCCGAAAAA	0.537000													6	12					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54373514	54373514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:54373514C>T	ENST00000306888.2	-	3	708	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	FIP1L1_ENST00000507166.1_Intron|LNX1-AS1_ENST00000511989.1_RNA|LNX1_ENST00000263925.7_Missense_Mutation_p.E249K|LNX1-AS1_ENST00000514364.1_RNA|LNX1-AS1_ENST00000510785.1_RNA	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	249						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TCAGAATTTTCCCTGCCCTGG	0.488000													30	81					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475061	16475061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16475061G>A	ENST00000358432.5	-	3	789	c.635C>T	c.(634-636)cCt>cTt	p.P212L	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	212	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GATGGTCTCAGGGAAGTGGGC	0.652000													19	48					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3753941	3753941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3753941G>A	ENST00000378230.3	-	9	1358	c.1034C>T	c.(1033-1035)cCt>cTt	p.P345L		NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa	345						centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						ATATGATGAAGGCTTTTCCTG	0.448000													18	42					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922226	37922226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37922226C>T	ENST00000346872.3	-	8	1408	c.1347G>A	c.(1345-1347)atG>atA	p.M449I	IKZF3_ENST00000346243.3_Missense_Mutation_p.M371I|IKZF3_ENST00000377944.3_Missense_Mutation_p.M306I|IKZF3_ENST00000377952.2_Missense_Mutation_p.M228I|IKZF3_ENST00000377945.3_Missense_Mutation_p.M315I|IKZF3_ENST00000467757.1_Missense_Mutation_p.M393I|IKZF3_ENST00000535189.1_Missense_Mutation_p.M415I|IKZF3_ENST00000439167.2_Missense_Mutation_p.M376I|IKZF3_ENST00000351680.3_Missense_Mutation_p.M410I|IKZF3_ENST00000439016.2_Missense_Mutation_p.M354I|IKZF3_ENST00000583368.1_Missense_Mutation_p.M202I|IKZF3_ENST00000394189.2_Missense_Mutation_p.M267I|IKZF3_ENST00000377958.2_Missense_Mutation_p.M362I|IKZF3_ENST00000350532.3_Missense_Mutation_p.M410I	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	449					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATACACATCCATCACCTCCC	0.557000													57	66					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873265	36873265	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36873265G>A	ENST00000301807.6	-	21	7924	c.6027C>T	c.(6025-6027)tgC>tgT	p.C2009C	TRANK1_ENST00000429976.2_Silent_p.C2559C|TRANK1_ENST00000428977.2_Silent_p.C2009C	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2559					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CCTGGCCAGGGCAGTCCATGC	0.572000													27	72					0	0	1	0	0
SLC35D2	11046	broad.mit.edu	37	9	99126776	99126776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:99126776G>A	ENST00000253270.7	-	3	311	c.249C>T	c.(247-249)ttC>ttT	p.F83F	SLC35D2_ENST00000375259.4_Silent_p.F83F|SLC35D2_ENST00000375257.1_Silent_p.F83F|SLC35D2_ENST00000482643.1_5'UTR	NM_007001.2	NP_008932.2	Q76EJ3	S35D2_HUMAN	solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2	83						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity			endometrium(3)|large_intestine(3)|lung(4)|skin(2)	12		Acute lymphoblastic leukemia(62;0.0167)				CAAAATCAGGGAAGTGAATGA	0.338000													46	127					0	0	1	0	0
VPS35	55737	broad.mit.edu	37	16	46716030	46716030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:46716030G>A	ENST00000299138.7	-	3	218	c.160C>T	c.(160-162)Cgg>Tgg	p.R54W		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	54					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				ATAGAAGTCCGGAGTTCACCA	0.333000													10	41					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126784913	126784913	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:126784913C>T	ENST00000274473.6	+	23	3246	c.2980_splice	c.e23+1	p.L993_splice	MEGF10_ENST00000503335.2_Splice_Site_p.L993_splice|MEGF10_ENST00000510828.1_3'UTR	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	993	Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TCAACGAGCTCGGTGAGTTCT	0.532000													34	68					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41594887	41594887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41594887C>T	ENST00000330436.3	+	2	234	c.234C>T	c.(232-234)gtC>gtT	p.V78V		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	78					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	CCCGGCGGGTCGTGGTGCTGT	0.637000													26	82					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79026783	79026783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79026783C>T	ENST00000446378.2	+	2	2226	c.2195C>T	c.(2194-2196)cCa>cTa	p.P732L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	732						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TACATGATTCCATCAGAAGAG	0.448000													24	69					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33411949	33411949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33411949G>A	ENST00000404816.2	+	6	1581	c.1228G>A	c.(1228-1230)Ggt>Agt	p.G410S	LTBP1_ENST00000402934.1_Missense_Mutation_p.G84S|LTBP1_ENST00000354476.3_Missense_Mutation_p.G410S|LTBP1_ENST00000404525.1_Missense_Mutation_p.G84S|LTBP1_ENST00000407925.1_Missense_Mutation_p.G84S|LTBP1_ENST00000390003.4_Missense_Mutation_p.G84S|LTBP1_ENST00000418533.2_Missense_Mutation_p.G84S			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	410	EGF-like 2.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity	p.G410C(1)		breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ATGTATGAATGGTGGCCAGTG	0.433000													20	45					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35504607	35504607	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35504607G>A	ENST00000217320.3	+	1	74	c.30G>A	c.(28-30)cgG>cgA	p.R10R	TLDC2_ENST00000602922.1_Silent_p.R10R	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		GTTACACTCGGCTGGTAAGGG	0.637000													13	132					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383132	22383132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22383132C>T	ENST00000328795.4	+	1	751	c.660C>T	c.(658-660)gtC>gtT	p.V220V	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCTATGCAGTCATCCTCTGCC	0.502000													27	81					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631980	32631980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32631980G>A	ENST00000242310.4	-	1	3687	c.3598C>T	c.(3598-3600)Cgc>Tgc	p.R1200C		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1200					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GTCTCACAGCGAACATACTCT	0.428000													15	142					0	0	1	0	0
ASTE1	28990	broad.mit.edu	37	3	130743962	130743962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130743962G>A	ENST00000264992.3	-	3	630	c.189C>T	c.(187-189)ttC>ttT	p.F63F	ASTE1_ENST00000514044.1_Silent_p.F63F	NM_014065.2	NP_054784.2	Q2TB18	ASTE1_HUMAN	asteroid homolog 1 (Drosophila)	63					DNA repair		nuclease activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)	22						GTGATTCAAAGAATTTTTGTA	0.363000													12	98					0	0	1	0	0
RBP5	83758	broad.mit.edu	37	12	7280989	7280989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7280989G>A	ENST00000266560.3	-	2	265	c.99C>T	c.(97-99)atC>atT	p.I33I	RBP5_ENST00000542370.1_Silent_p.I33I	NM_031491.2	NP_113679.1	P82980	RET5_HUMAN	retinol binding protein 5, cellular	33						cytoplasm	retinal binding|retinol binding|transporter activity			autonomic_ganglia(1)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)	10					Vitamin A(DB00162)	GCAGCAGCGCGATCTTCCGCA	0.607000													14	54					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23912862	23912862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:23912862G>A	ENST00000382298.3	-	10	5741	c.5153C>T	c.(5152-5154)tCc>tTc	p.S1718F	SACS_ENST00000402364.1_Missense_Mutation_p.S968F|SACS_ENST00000382292.3_Missense_Mutation_p.S1718F	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1718					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GGAAGAGCAGGATTTTTTTTT	0.358000													40	29					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93090139	93090139	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:93090139C>T	ENST00000359558.2	-	10	1043	c.744G>A	c.(742-744)agG>agA	p.R248R	CALCR_ENST00000426151.1_Silent_p.R214R|CALCR_ENST00000360249.4_Silent_p.R230R|CALCR_ENST00000394441.1_Silent_p.R214R|CALCR_ENST00000421592.1_Silent_p.R230R	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	230					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TTACCGGGTCCCTTCGCACGA	0.383000													23	115					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9523354	9523354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9523354G>A	ENST00000378429.3	-	10	2429	c.1883C>T	c.(1882-1884)tCc>tTc	p.S628F	PAK7_ENST00000378423.1_Missense_Mutation_p.S628F|PAK7_ENST00000353224.5_Missense_Mutation_p.S628F	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	628	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GATCCCGAGGGACCAGATGTC	0.517000													18	74					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46801068	46801068	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46801068G>A	ENST00000230588.4	+	11	1411	c.1402G>A	c.(1402-1404)Ggg>Agg	p.G468R		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	468	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			ATATGGTTTTGGGGTAACTTT	0.493000													31	77					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56443363	56443363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56443363C>T	ENST00000588751.1	-	1	339	c.315G>A	c.(313-315)atG>atA	p.M105I	NLRP13_ENST00000342929.3_Missense_Mutation_p.M105I			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	105	DAPIN.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TCTCACCTTTCATCTCGGCTC	0.532000													14	44					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88420335	88420335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:88420335C>T	ENST00000298699.2	-	3	243	c.63G>A	c.(61-63)gtG>gtA	p.V21V	C12orf50_ENST00000550553.1_Silent_p.V21V	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	21										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						AGCTGATCTTCACACAACCAA	0.368000													7	78					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184610	6184610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6184610G>A	ENST00000262450.3	-	30	4605	c.4506C>T	c.(4504-4506)acC>acT	p.T1502T	CHD5_ENST00000378021.1_Silent_p.T359T	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1502					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCCCGATGCGGGTCAGCACGT	0.647000													11	27					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37732434	37732434	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:37732434G>A	ENST00000330843.4	-	3	1233	c.1221C>T	c.(1219-1221)gaC>gaT	p.D407D	RAB11FIP1_ENST00000524118.1_Silent_p.D259D|RAB11FIP1_ENST00000287263.4_Silent_p.D407D|RAB11FIP1_ENST00000522727.1_Silent_p.D259D	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	407					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TTTCCCTGAGGTCCCCACTGA	0.562000													25	74					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535765	69535765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69535765G>A	ENST00000338206.5	-	1	581	c.572C>T	c.(571-573)cCt>cTt	p.P191L		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	191					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										ATAGGAAGGAGGGAACAGAAA	0.368000													52	216					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57171830	57171830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57171830G>A	ENST00000371244.4	+	8	1425	c.1359G>A	c.(1357-1359)atG>atA	p.M453I		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	453					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						ACGTGAAAATGAGCTTACAAC	0.343000													28	63					0	0	1	0	0
SLC2A12	154091	broad.mit.edu	37	6	134350251	134350251	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:134350251C>T	ENST00000275230.5	-	2	867	c.712G>A	c.(712-714)Gga>Aga	p.G238R		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	238						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		CTTAACCTTCCAAGAACCTTG	0.443000													33	42					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151094619	151094619	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151094619G>A	ENST00000474524.1	+	27	4018	c.3980G>A	c.(3979-3981)tGg>tAg	p.W1327*	MED12L_ENST00000273432.4_Nonsense_Mutation_p.W1187*|P2RY12_ENST00000302632.3_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1327					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGGCAATCCTGGTTAGAACTC	0.343000													12	73					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196722403	196722403	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196722403G>T	ENST00000312428.6	-	44	8212	c.8112C>A	c.(8110-8112)gtC>gtA	p.V2704V		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2704	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TAACAAGCTTGACACCAGCAG	0.368000													12	53					1.49906e-05	1.50194e-05	1	1	0
OR13A1	79290	broad.mit.edu	37	10	45799190	45799190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45799190C>T	ENST00000553795.1	-	4	989	c.681G>A	c.(679-681)gtG>gtA	p.V227V	OR13A1_ENST00000374401.2_Silent_p.V227V|OR13A1_ENST00000536058.1_Silent_p.V227V	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						TCAGGAAGTTCACTATGCCGT	0.552000													20	78					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122001066	122001066	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122001066A>T	ENST00000498619.1	+	6	2183	c.1745A>T	c.(1744-1746)gAg>gTg	p.E582V	CASR_ENST00000296154.5_Missense_Mutation_p.E572V|CASR_ENST00000490131.1_Missense_Mutation_p.E572V	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	572			C -> F (in FHH).|C -> Y (in NSHPT).		anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCTGATGGGGAGTATAGTGAT	0.597000													29	66					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579837	55579837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55579837G>A	ENST00000333973.2	+	1	984	c.895G>A	c.(895-897)Gaa>Aaa	p.E299K		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				AGATGTGAAAGAAGCTCTCAG	0.463000													22	51					0	0	1	0	0
CNOT6L	246175	broad.mit.edu	37	4	78641627	78641627	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:78641627G>A	ENST00000504123.1	-	12	1756	c.1626C>T	c.(1624-1626)ctC>ctT	p.L542L	CNOT6L_ENST00000264903.4_Silent_p.L542L			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	542					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						CAAGAGGCAGGAGTGGAGGGT	0.507000													28	120					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188634	140188634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140188634C>T	ENST00000530339.1	+	1	1862	c.1862C>T	c.(1861-1863)cCg>cTg	p.P621L	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.P621L|PCDHA4_ENST00000512229.2_Missense_Mutation_p.P621L|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1												p.P621L(2)		breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCATCCCGTTCCGCGTG	0.672000													25	84					0	0	1	0	0
XPO6	23214	broad.mit.edu	37	16	28118871	28118871	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28118871G>A	ENST00000304658.5	-	18	2969	c.2469C>T	c.(2467-2469)gcC>gcT	p.A823A	XPO6_ENST00000565698.1_Silent_p.A809A	NM_015171.2	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	823					protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						CTGGAAAGAGGGCCAGGGAGA	0.532000													26	71					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165175145	165175145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165175145C>T	ENST00000342310.3	-	8	1326	c.944G>A	c.(943-945)gGt>gAt	p.G315D	LMX1A_ENST00000367893.4_Missense_Mutation_p.G315D|LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Missense_Mutation_p.G315D	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	315						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					TGGGGTGAGACCCTGTCGGAA	0.577000													28	57					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180056393	180056393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180056393G>A	ENST00000261937.6	-	7	929	c.851C>T	c.(850-852)tCc>tTc	p.S284F	FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Missense_Mutation_p.S284F|FLT4_ENST00000502649.1_Missense_Mutation_p.S284F	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	284	Ig-like C2-type 3.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GGTCTGCTGGGAGCGTCGCTC	0.657000													20	35					0	0	1	0	0
LRRC48	83450	broad.mit.edu	37	17	17891358	17891358	+	Silent	SNP	C	C	T	rs145108400	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:17891358C>T	ENST00000313838.8	+	6	769	c.390C>T	c.(388-390)ctC>ctT	p.L130L	LRRC48_ENST00000411504.2_Silent_p.L130L|LRRC48_ENST00000399182.1_Silent_p.L130L|LRRC48_ENST00000399187.1_Silent_p.L130L|LRRC48_ENST00000584166.1_Silent_p.L130L	NM_001130090.1	NP_001123562.1	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48	130						cytoplasm				breast(1)|large_intestine(2)|lung(2)|pancreas(1)|urinary_tract(1)	7	all_neural(463;0.228)					TGGACGCCCTCGTCAAGCTGC	0.587000													14	29					0	0	1	0	0
WAS	7454	broad.mit.edu	37	X	48542353	48542353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48542353G>A	ENST00000376701.4	+	1	186	c.111G>A	c.(109-111)gaG>gaA	p.E37E	WAS_ENST00000483750.1_3'UTR	NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	37					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				GACTCTTTGAGATGCTTGGAC	0.622000			"""Mis, N, F, S"""			lymphoma							38	26					0	0	1	0	0
TMEM125	128218	broad.mit.edu	37	1	43738463	43738463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43738463G>A	ENST00000432792.2	+	4	640	c.70G>A	c.(70-72)Gag>Aag	p.E24K	TMEM125_ENST00000439858.1_Missense_Mutation_p.E24K			Q96AQ2	TM125_HUMAN	transmembrane protein 125	24						integral to membrane				breast(1)|large_intestine(1)|lung(1)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGAGCAGGTGGAGCTGTGGTG	0.721000													8	8					0	0	1	0	0
CETN1	1068	broad.mit.edu	37	18	580874	580874	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:580874G>A	ENST00000327228.3	+	1	508	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	156	EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						TGGGGACGGCGAAGTGAACGA	0.537000													40	22					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141081603	141081603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141081603C>T	ENST00000389484.3	-	81	13344	c.12373G>A	c.(12373-12375)Gaa>Aaa	p.E4125K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4125					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATATAATCTTCAAAGATATCG	0.289000										TSP Lung(27;0.18)			38	111					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30366743	30366743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30366743G>A	ENST00000340513.4	+	10	1538	c.1010G>A	c.(1009-1011)cGa>cAa	p.R337Q	TPX2_ENST00000300403.6_Missense_Mutation_p.R337Q			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	337					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			TTCCATAAACGAACCCCTAAC	0.413000													44	94					0	0	1	0	0
LUZP2	338645	broad.mit.edu	37	11	24759824	24759824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:24759824G>A	ENST00000533227.1	+	4	338	c.51G>A	c.(49-51)gaG>gaA	p.E17E	LUZP2_ENST00000336930.6_Silent_p.E103E|LUZP2_ENST00000531187.1_3'UTR	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	103						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						AGACATCAGAGAAAGCAGAAA	0.373000													15	37					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25280503	25280503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25280503G>A	ENST00000218548.6	+	15	2422	c.2089G>A	c.(2089-2091)Gaa>Aaa	p.E697K	ATP12A_ENST00000381946.3_Missense_Mutation_p.E691K	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	691					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CATGAGCTCAGAACAGCTGGA	0.562000													22	56					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	69281668	69281668	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:69281668G>A	ENST00000433211.1	-	5	685	c.511C>T	c.(511-513)Cag>Tag	p.Q171*	CTNNA3_ENST00000545309.1_Nonsense_Mutation_p.Q171*|CTNNA3_ENST00000373744.4_Nonsense_Mutation_p.Q171*	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	171					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TAGGTTTTCTGGAGGTCAGAT	0.408000													36	88					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100087130	100087130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100087130G>A	ENST00000423930.1	+	4	1945	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	NYAP1_ENST00000300179.2_Missense_Mutation_p.D596N|NYAP1_ENST00000454988.1_Missense_Mutation_p.D539N			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	596																	GCAAGGGACCGATGGGGGTGC	0.637000													31	60					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38957887	38957887	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38957887C>T	ENST00000359357.3	+	86	12756	c.12502C>T	c.(12502-12504)Cag>Tag	p.Q4168*	DNAH8_ENST00000441566.1_Nonsense_Mutation_p.Q4132*					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGAATACATCCAGTCACTGCC	0.408000													63	182					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130292831	130292831	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130292831C>T	ENST00000358511.6	+	7	3040	c.3009C>T	c.(3007-3009)ttC>ttT	p.F1003F	COL6A6_ENST00000453409.2_Silent_p.F1003F	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1003	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ATCTTGTTTTCCTTATGGATG	0.363000													11	33					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55542468	55542468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55542468G>A	ENST00000220676.1	+	4	6174	c.6026G>A	c.(6025-6027)aGa>aAa	p.R2009K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	2009					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAACAAAAAAGAATTAACTTC	0.294000													43	81					0	0	1	0	0
OR52E2	119678	broad.mit.edu	37	11	5080338	5080338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5080338G>A	ENST00000321522.2	-	1	519	c.520C>T	c.(520-522)Cat>Tat	p.H174Y		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGAATTACATGATTCCCACAG	0.403000													12	32					0	0	1	0	0
AK2	204	broad.mit.edu	37	1	33478956	33478956	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33478956G>A	ENST00000373449.2	-	6	587	c.546C>T	c.(544-546)gcC>gcT	p.A182A	AK2_ENST00000480134.1_3'UTR|RP1-117O3.2_ENST00000427524.1_RNA|AK2_ENST00000548033.1_Silent_p.A140A|AK2_ENST00000467905.1_Silent_p.A182A|AK2_ENST00000354858.6_Silent_p.A182A	NM_001199199.1|NM_013411.4	NP_001186128.1|NP_037543.1	P54819	KAD2_HUMAN	adenylate kinase 2	182					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				GGATTTTCAAGGCCTTTTCAT	0.512000													24	36					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148927953	148927953	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:148927953C>T	ENST00000264613.6	-	3	870		c.e3+1			NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)						cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	AGAAGATGTACCTTTTTTACA	0.403000													27	68					0	0	1	0	0
BCO2	83875	broad.mit.edu	37	11	112070448	112070448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:112070448C>T	ENST00000357685.5	+	6	898	c.763C>T	c.(763-765)Cct>Tct	p.P255S	BCO2_ENST00000531169.1_Missense_Mutation_p.P221S|BCO2_ENST00000361053.4_Missense_Mutation_p.P182S|BCO2_ENST00000526088.1_Missense_Mutation_p.P221S|BCO2_ENST00000393032.2_Missense_Mutation_p.P221S|BCO2_ENST00000438022.1_Missense_Mutation_p.P221S|BCO2_ENST00000532593.1_Missense_Mutation_p.P150S|SDHD_ENST00000532612.1_3'UTR			Q9BYV7	BCDO2_HUMAN	beta-carotene oxygenase 2	255					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)	16						TATTCGGGTTCCTCCAGAGAA	0.403000													42	104					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74824431	74824431	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74824431C>T	ENST00000256362.4	+	2	1186	c.945C>T	c.(943-945)tcC>tcT	p.S315S		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	315					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CCCGCTTCTCCGCCAAGCACT	0.632000													25	75					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51054653	51054653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51054653G>A	ENST00000441560.2	+	3	620	c.139G>A	c.(139-141)Gag>Aag	p.E47K	ATL1_ENST00000354525.4_Missense_Mutation_p.E47K|ATL1_ENST00000357032.3_Missense_Mutation_p.E47K|ATL1_ENST00000556478.2_3'UTR|ATL1_ENST00000358385.6_Missense_Mutation_p.E47K	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	47					axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						CCATTCCTTTGAGTTAGATGA	0.438000													57	139					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997813	46997813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46997813C>T	ENST00000599531.1	-	1	1942	c.910G>A	c.(910-912)Gag>Aag	p.E304K	AC011484.1_ENST00000377652.3_5'UTR|PNMAL2_ENST00000594749.1_Intron|PNMAL2_ENST00000377655.2_Intron	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	304										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ACCGGCTCCTCGTCCGGGGTG	0.582000													13	112					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171071264	171071264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171071264G>A	ENST00000334231.6	+	5	479	c.479G>A	c.(478-480)cGa>cAa	p.R160Q	MYO3B_ENST00000408978.4_Missense_Mutation_p.R151Q|MYO3B_ENST00000409044.3_Missense_Mutation_p.R151Q|MYO3B_ENST00000602629.1_Intron			Q8WXR4	MYO3B_HUMAN	myosin IIIB	151	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						CACAACAACCGAATCATCCAC	0.428000													19	51					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176798513	176798513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176798513C>T	ENST00000408923.3	+	14	1609	c.1421C>T	c.(1420-1422)cCc>cTc	p.P474L	RGS14_ENST00000506944.1_3'UTR	NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	474					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCACCCATCCCCCTCCAGCG	0.597000													42	214					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32818262	32818262	+	Silent	SNP	C	C	T	rs146000974	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32818262C>T	ENST00000380250.3	+	47	7267	c.6771C>T	c.(6769-6771)gtC>gtT	p.V2257V		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACCTTTCTGTCGTTCCTGTCA	0.478000													34	114					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6867339	6867339	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6867339G>A	ENST00000299454.4	+	1	457	c.426G>A	c.(424-426)cgG>cgA	p.R142R	OR10A5_ENST00000379831.2_Silent_p.R146R			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAAGGACACGGGCCAAACTGG	0.537000													40	146					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23782435	23782435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23782435G>A	ENST00000336689.3	-	3	331	c.287C>T	c.(286-288)tCc>tTc	p.S96F	ASAP3_ENST00000437606.2_Missense_Mutation_p.S96F	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	96					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						GAAGCCTGTGGACAGCTCATG	0.572000													40	90					0	0	1	0	0
TMEM218	219854	broad.mit.edu	37	11	124967604	124967604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124967604G>A	ENST00000455225.1	-	4	897	c.246C>T	c.(244-246)gtC>gtT	p.V82V	TMEM218_ENST00000532407.1_Silent_p.V82V|TMEM218_ENST00000279968.4_Silent_p.V82V|TMEM218_ENST00000528724.1_Silent_p.V108V|TMEM218_ENST00000531262.1_5'UTR|TMEM218_ENST00000529609.1_3'UTR|TMEM218_ENST00000527271.1_Silent_p.V82V|TMEM218_ENST00000531909.1_Silent_p.V82V|TMEM218_ENST00000526175.1_Silent_p.V82V|TMEM218_ENST00000532156.1_3'UTR|TMEM218_ENST00000529583.1_Silent_p.V82V|TMEM218_ENST00000527766.1_Silent_p.V82V			A2RU14	TM218_HUMAN	transmembrane protein 218	82						integral to membrane		p.V82V(1)		breast(1)|large_intestine(2)|lung(1)|prostate(1)	5						AAGCCAGCAGGACATAGCGGC	0.448000													7	36					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59170239	59170239	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59170239G>A	ENST00000262717.4	+	5	1113	c.715G>A	c.(715-717)Gaa>Aaa	p.E239K	CDH20_ENST00000536675.2_Missense_Mutation_p.E239K|CDH20_ENST00000538374.1_Missense_Mutation_p.E239K			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	239	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				AGAATACTACGAAGTGATTAT	0.448000											OREG0025026	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	103					0	0	1	0	0
RAD54L	8438	broad.mit.edu	37	1	46733199	46733199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46733199G>A	ENST00000371975.4	+	9	1634	c.960G>A	c.(958-960)cgG>cgA	p.R320R	RAD54L_ENST00000442598.1_Silent_p.R320R	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	320	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		CCAGCCGGCGGGTGCTCATCT	0.483000								Direct reversal of damage;Homologous recombination					35	64					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39915363	39915363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39915363C>T	ENST00000425673.1	+	17	3828	c.3503C>T	c.(3502-3504)tCg>tTg	p.S1168L	PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.S1138L|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.S1197L			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	1197	Pro-rich.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTCACACCTTCGTTGGAGCAG	0.572000													82	195					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68972915	68972915	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68972915G>A	ENST00000288368.4	+	11	1517	c.1238_splice	c.e11-1	p.E414_splice	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	414	DEP 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.E414K(2)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CTCTTGCAGCGAATTTGTGTC	0.418000													19	66					0	0	1	0	0
UBXN4	23190	broad.mit.edu	37	2	136537829	136537829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136537829C>T	ENST00000272638.9	+	12	1573	c.1262C>T	c.(1261-1263)cCa>cTa	p.P421L	UBXN4_ENST00000490163.1_3'UTR	NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	421					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						GTGCTTTATCCATTCCTTGCC	0.438000													45	121					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24454270	24454270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24454270C>T	ENST00000230036.1	-	14	1418	c.1308G>A	c.(1306-1308)gaG>gaA	p.E436E		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	436						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TCCTGTGGGCCTCCTTGTCCA	0.567000													29	85					0	0	1	0	0
C10orf113	387638	broad.mit.edu	37	10	21414830	21414830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21414830C>T	ENST00000534331.1	-	2	440	c.390G>A	c.(388-390)ggG>ggA	p.G130G	C10orf113_ENST00000529198.1_3'UTR|NEBL_ENST00000417816.2_Intron|C10orf113_ENST00000377118.4_Silent_p.G120G	NM_001010896.2	NP_001010896.2	Q5VZT2	CJ113_HUMAN	chromosome 10 open reading frame 113	130										endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|pancreas(1)	7						ATCCATGCTTCCCTTTGGTTA	0.463000													55	114					0	0	1	0	0
SLC18A1	6570	broad.mit.edu	37	8	20035989	20035989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:20035989G>A	ENST00000440926.1	-	5	974	c.504C>T	c.(502-504)atC>atT	p.I168I	SLC18A1_ENST00000265808.7_Silent_p.I168I|SLC18A1_ENST00000276373.5_Silent_p.I168I|SLC18A1_ENST00000519026.1_Silent_p.I168I|SLC18A1_ENST00000437980.1_Silent_p.I168I|SLC18A1_ENST00000381608.4_Silent_p.I168I	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1	168					neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		CAAACATGGGGATATGATATC	0.348000													6	20					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241987827	241987827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241987827G>A	ENST00000310397.8	+	9	1369	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K	SNED1_ENST00000405547.3_Missense_Mutation_p.E457K|SNED1_ENST00000342631.6_Missense_Mutation_p.E457K|SNED1_ENST00000401884.1_Missense_Mutation_p.E457K|AC005237.4_ENST00000458377.1_RNA|SNED1_ENST00000469006.1_3'UTR	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	457	EGF-like 5.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		CGAGTGCCCCGAAGGCTTCAT	0.667000													4	20					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723158	58723158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58723158G>A	ENST00000300079.5	+	7	710	c.660G>A	c.(658-660)ggG>ggA	p.G220G	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Silent_p.G189G	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	189						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	GGAAGCGAGGGAAGAATGAGA	0.498000													16	72					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18735519	18735519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18735519C>T	ENST00000513874.1	-	14	2114	c.1975G>A	c.(1975-1977)Ggg>Agg	p.G659R	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	659	Ig-like 4.							p.G659R(1)		NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TGGTCTTCCCCGCGCTCCATG	0.592000													28	76					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5759096	5759096	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5759096G>A	ENST00000381624.3	+	15	1429		c.e15-1		CATSPERD_ENST00000309164.7_Splice_Site|CATSPERD_ENST00000381614.2_Splice_Site	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta							integral to membrane											TGACCCCACAGGATATTTTCC	0.557000													32	109					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10408483	10408483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10408483C>T	ENST00000226207.5	-	21	2526	c.2432G>A	c.(2431-2433)aGa>aAa	p.R811K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	811	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTAATACCTTCTTTCCACCAT	0.418000													26	71					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109688977	109688977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:109688977G>A	ENST00000277225.5	+	3	3073	c.2784G>A	c.(2782-2784)cgG>cgA	p.R928R	ZNF462_ENST00000457913.1_Silent_p.R928R			Q96JM2	ZN462_HUMAN	zinc finger protein 462	928					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						ACCGGTGTCGGTTTTGTTCAT	0.473000													12	140					0	0	1	0	0
SPAG1	6674	broad.mit.edu	37	8	101206519	101206519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101206519G>A	ENST00000520508.1	+	10	1403	c.1119G>A	c.(1117-1119)agG>agA	p.R373R	SPAG1_ENST00000520643.1_Silent_p.R373R|SPAG1_ENST00000388798.2_Intron|SPAG1_ENST00000251809.3_Intron			Q07617	SPAG1_HUMAN	sperm associated antigen 1	0					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TTCTATTTAGGTTATGTAAAA	0.323000													5	21					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120138561	120138561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120138561G>A	ENST00000392521.2	-	44	5667	c.5612C>T	c.(5611-5613)cCt>cTt	p.P1871L	RP1-127H14.3_ENST00000535109.1_Missense_Mutation_p.G50S|CIT_ENST00000261833.7_Missense_Mutation_p.P1829L|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1829	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		AAAGGCCAAAGGTAAGCGACT	0.547000													10	88					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174830	150174830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150174830G>A	ENST00000307271.3	+	5	2534	c.1960G>A	c.(1960-1962)Gaa>Aaa	p.E654K		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	654						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GTCCCAAGCCGAAAAACTCCT	0.463000													22	65					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154303543	154303543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154303543C>T	ENST00000368489.3	+	5	323	c.323C>T	c.(322-324)tCc>tTc	p.S108F	ATP8B2_ENST00000426445.1_3'UTR|ATP8B2_ENST00000368487.3_Missense_Mutation_p.S75F|ATP8B2_ENST00000341822.2_Missense_Mutation_p.S94F	NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	94					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAGATCTCTTCCCTGTCCTGG	0.458000													17	75					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38851680	38851680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38851680G>A	ENST00000359357.3	+	54	7768	c.7514G>A	c.(7513-7515)cGa>cAa	p.R2505Q	DNAH8_ENST00000449981.2_Missense_Mutation_p.R2722Q|DNAH8_ENST00000441566.1_Missense_Mutation_p.R2469Q					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTGGATAAGCGAATTGGAAGC	0.363000													39	72					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169484792	169484792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169484792C>T	ENST00000367796.3	-	24	6634	c.6433G>A	c.(6433-6435)Ggc>Agc	p.G2145S	F5_ENST00000495481.1_5'UTR|F5_ENST00000367797.3_Missense_Mutation_p.G2140S			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	2140	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GACTTGCAGCCCTGTGTTATA	0.398000													46	126					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109707875	109707875	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109707875C>T	ENST00000356711.2	+	27	3327	c.3201C>T	c.(3199-3201)gtC>gtT	p.V1067V	MYO16_ENST00000457511.2_Silent_p.V579V|MYO16_ENST00000357550.2_Silent_p.V1067V	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1067	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATATTGGGGTCCTGGAGATGG	0.428000													31	121					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52580396	52580396	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52580396C>T	ENST00000395489.2	-	10	1158	c.762G>A	c.(760-762)agG>agA	p.R254R	A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000373993.1_Silent_p.R261R|A1CF_ENST00000282641.2_Silent_p.R261R|A1CF_ENST00000373997.3_Silent_p.R261R|A1CF_ENST00000374001.1_Silent_p.R261R|A1CF_ENST00000395495.1_Silent_p.R206R|A1CF_ENST00000373995.3_Silent_p.R269R	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	261	RRM 3.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TTTTCTTCACCCTCTCCACAG	0.393000													8	62					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94508333	94508333	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94508333G>A	ENST00000370225.3	-	22	3398	c.3312C>T	c.(3310-3312)ctC>ctT	p.L1104L		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1104	ABC transporter 1.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GATACTTCAGGAGCAGATCCC	0.572000													16	37					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106907399	106907399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106907399G>A	ENST00000369701.3	+	9	1554	c.1327G>A	c.(1327-1329)Gag>Aag	p.E443K		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	443						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAGTACAGACGAGAACCAAGT	0.473000													30	79					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885581	24885581	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24885581G>A	ENST00000382554.3	+	9	4944	c.4626G>A	c.(4624-4626)agG>agA	p.R1542R		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1542					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						AACTCCGGAGGGATCTGATTT	0.567000													9	11					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20216109	20216109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20216109G>A	ENST00000418063.2	+	3	322	c.210G>A	c.(208-210)atG>atA	p.M70I	ZNF90_ENST00000474284.1_3'UTR	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	70	KRAB.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						GACATGAGATGATTGCCAAAT	0.408000													29	94					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135690087	135690087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135690087G>A	ENST00000298545.3	-	10	1438	c.917C>T	c.(916-918)gCt>gTt	p.A306V	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	306	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						ATCTGCCACAGCCTCTTTCAG	0.493000													16	53					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67686146	67686146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67686146C>T	ENST00000334583.6	+	27	3049	c.2721C>T	c.(2719-2721)gcC>gcT	p.A907A	RLTPR_ENST00000545661.1_Silent_p.A871A	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	907	Pro-rich.									breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		TGCCCCCTGCCCTACCAGCAC	0.567000													23	113					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705633	101705633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:101705633G>A	ENST00000305352.6	+	2	1468	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	365					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						CCAGAAAGACGAAGGGGACAA	0.547000													30	81					0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77475383	77475383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:77475383C>T	ENST00000299543.7	+	8	2070	c.1923C>T	c.(1921-1923)ttC>ttT	p.F641F	CTDP1_ENST00000075430.7_Silent_p.F641F	NM_001202504.1|NM_004715.4	NP_001189433.1|NP_004706.3	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	641	BRCT.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CCATAATTTTCAGTGGGCTAC	0.597000													4	13					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21015720	21015720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21015720C>T	ENST00000381545.3	+	8	878	c.659C>T	c.(658-660)cCa>cTa	p.P220L	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.P220L|LST3_ENST00000540229.1_Missense_Mutation_p.P220L|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.P220L|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	220					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATGATTGGTCCAGTCATTGGC	0.333000													19	134					0	0	1	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46387882	46387882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46387882G>A	ENST00000302165.3	-	1	1494	c.1151C>T	c.(1150-1152)tCc>tTc	p.S384F		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CGGCTCGGGGGATGCCTTGCG	0.746000													5	29					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129123150	129123150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129123150G>A	ENST00000505956.1	-	7	1508	c.1346C>T	c.(1345-1347)tCt>tTt	p.S449F	EFCAB12_ENST00000326085.3_Missense_Mutation_p.S449F	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		CAGATTCGGAGAAAAGACCTT	0.572000													34	90					0	0	1	0	0
NR2E1	7101	broad.mit.edu	37	6	108489317	108489317	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:108489317C>T	ENST00000368983.3	+	1	91	c.87C>T	c.(85-87)ttC>ttT	p.F29F	NR2E1_ENST00000368986.4_Intron			Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	0					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		GACTGGGTTTCCCTTTAGGCT	0.597000													4	10					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065577	55065577	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55065577C>T	ENST00000526016.1	-	0	131					NR_038174.2																						CATGTTGTCTCCTTGCATTTA	0.493000													13	30					0	0	1	0	0
GAA	2548	broad.mit.edu	37	17	78084749	78084749	+	Missense_Mutation	SNP	G	G	A	rs121907937		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78084749G>A	ENST00000302262.3	+	11	1780	c.1561G>A	c.(1561-1563)Gag>Aag	p.E521K	GAA_ENST00000390015.3_Missense_Mutation_p.E521K	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	521			E -> K (in GSD2; severe).		cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGACATGAACGAGCCTTCCAA	0.632000													7	59					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255810	15255810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15255810C>T	ENST00000378116.4	-	8	1783	c.1777G>A	c.(1777-1779)Gac>Aac	p.D593N		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	593						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TAGGAGTGGTCCCCGGGGAGT	0.542000													59	63					0	0	1	0	0
GABRD	2563	broad.mit.edu	37	1	1961051	1961051	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1961051G>A	ENST00000378585.4	+	8	992	c.909G>A	c.(907-909)cgG>cgA	p.R303R		NM_000815.4	NP_000806.2	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	303						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		CCCTGCCACGGGCATCAGCCA	0.607000													9	39					0	0	1	0	0
SLC30A8	169026	broad.mit.edu	37	8	118165285	118165285	+	Missense_Mutation	SNP	C	C	T	rs148780595		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:118165285C>T	ENST00000427715.2	+	6	661	c.227C>T	c.(226-228)tCg>tTg	p.S76L	SLC30A8_ENST00000521243.1_Missense_Mutation_p.S76L|SLC30A8_ENST00000456015.2_Missense_Mutation_p.S125L|SLC30A8_ENST00000519688.1_Missense_Mutation_p.S76L	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	125					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity	p.S125*(2)		breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TGGTTGTCATCGAAGCCTCCC	0.527000													15	36					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51171299	51171299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51171299G>A	ENST00000440970.1	-	3	3839	c.3408C>T	c.(3406-3408)ttC>ttT	p.F1136F	SALL1_ENST00000541611.1_Silent_p.F56F|SALL1_ENST00000251020.4_Silent_p.F1233F|SALL1_ENST00000566102.1_3'UTR	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1233					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ACTGATTCCAGAAGCTGGAAG	0.542000													15	36					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32280440	32280440	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32280440C>T	ENST00000360482.2	-	2	624	c.495G>A	c.(493-495)agG>agA	p.R165R	SPOCD1_ENST00000257100.3_Intron|SPOCD1_ENST00000373648.2_Silent_p.R165R|SPOCD1_ENST00000533231.1_Silent_p.R165R	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	165					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CTCTGGCCTCCCTGGGCCTGA	0.617000													48	78					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186672571	186672571	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:186672571G>A	ENST00000343098.5	+	17	18805	c.18805G>A	c.(18805-18807)Gaa>Aaa	p.E6269K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E6180K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TAACATAATAGAAGAAATTGC	0.303000													16	48					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31318246	31318246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:31318246G>A	ENST00000380490.3	+	2	218	c.120G>A	c.(118-120)agG>agA	p.R40R	ALOX5AP_ENST00000479597.1_3'UTR	NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	40					cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		AGAATGGGAGGAGCTTCCAGA	0.542000													10	51					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220494887	220494887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220494887C>T	ENST00000358055.3	+	6	1136	c.624C>T	c.(622-624)ccC>ccT	p.P208P	SLC4A3_ENST00000273063.6_Silent_p.P235P|SLC4A3_ENST00000373760.2_Silent_p.P208P|SLC4A3_ENST00000497589.1_Intron|SLC4A3_ENST00000373762.3_Silent_p.P235P|SLC4A3_ENST00000317151.3_Silent_p.P208P			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	208					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCCAGCCCCCGGGCCCGGG	0.692000													3	15					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98592348	98592348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98592348C>T	ENST00000359863.4	+	66	10353	c.10144C>T	c.(10144-10146)Ctg>Ttg	p.L3382L	TRRAP_ENST00000355540.3_Silent_p.L3353L|TRRAP_ENST00000446306.3_Silent_p.L3371L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3382					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGGGTGGGCCTGGAGAATGT	0.567000													86	192					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174869243	174869243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:174869243G>A	ENST00000393752.2	-	2	1852	c.860C>T	c.(859-861)cCt>cTt	p.P287L		NM_000794.3	NP_000785.1	P21728	DRD1_HUMAN	dopamine receptor D1	287					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	GATGAAGAAAGGTAGCCAACA	0.463000													14	34					0	0	1	0	0
MAPK7	5598	broad.mit.edu	37	17	19286458	19286458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:19286458C>T	ENST00000308406.5	+	7	2751	c.2365C>T	c.(2365-2367)Cct>Tct	p.P789S	MAPK7_ENST00000395604.3_Missense_Mutation_p.P789S|MAPK7_ENST00000571657.1_3'UTR|MAPK7_ENST00000395602.4_Missense_Mutation_p.P789S|MAPK7_ENST00000299612.7_Missense_Mutation_p.P650S	NM_139033.2	NP_620602.2	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7	789	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					TGGCATGAACCCTGCCGATAT	0.612000													24	28					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764842	77764842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77764842C>T	ENST00000521891.2	+	10	6133	c.5685C>T	c.(5683-5685)atC>atT	p.I1895I	ZFHX4_ENST00000050961.6_Silent_p.I1850I|ZFHX4_ENST00000455469.2_Silent_p.I1850I|ZFHX4_ENST00000518282.1_Silent_p.I1869I	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1850						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACCATCCATCCCACCACCCC	0.433000										HNSCC(33;0.089)			8	16					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20216065	20216065	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20216065C>T	ENST00000418063.2	+	3	278	c.166C>T	c.(166-168)Ctg>Ttg	p.L56L	ZNF90_ENST00000474284.1_3'UTR	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	56	KRAB.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						GATCACCTGTCTGGAGCAAGG	0.388000													36	93					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32137577	32137577	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32137577C>T	ENST00000312561.4	+	4	4102	c.3688C>T	c.(3688-3690)Caa>Taa	p.Q1230*	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		CACTGTTGTTCAATTTAAGAG	0.378000													26	54					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256729	140256729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140256729G>A	ENST00000398631.2	+	1	1672	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCTGGACGAGAACGACAA	0.701000													66	153					0	0	1	0	0
DOK3	79930	broad.mit.edu	37	5	176931397	176931397	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176931397G>A	ENST00000501403.2	-	6	1259	c.910C>T	c.(910-912)Ccc>Tcc	p.P304S	DOK3_ENST00000357198.4_Missense_Mutation_p.P360S|DOK3_ENST00000377112.4_Intron|DOK3_ENST00000312943.6_Intron			Q7L591	DOK3_HUMAN	docking protein 3	360	IRS-type PTB.					cytoplasm|plasma membrane	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|lung(7)	13	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TGGGGTCCGGGCTCGGCCAGG	0.687000													4	25					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180064816	180064816	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:180064816G>A	ENST00000367607.3	+	35	9088	c.8670G>A	c.(8668-8670)aaG>aaA	p.K2890K	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2890						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AAAAAAATAAGGCAGAAGAAA	0.433000													21	54					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676126	123676126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123676126C>T	ENST00000309154.2	-	1	969	c.932G>A	c.(931-933)aGg>aAg	p.R311K		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		TCAAGTTTTCCTTTGTATCAA	0.378000													10	129					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582507	136582507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136582507G>A	ENST00000531224.1	-	12	2905	c.2653C>T	c.(2653-2655)Cct>Tct	p.P885S	BCLAF1_ENST00000392348.2_Missense_Mutation_p.P834S|BCLAF1_ENST00000530767.1_Missense_Mutation_p.P712S|BCLAF1_ENST00000031135.9_Missense_Mutation_p.P103S|BCLAF1_ENST00000527759.1_Missense_Mutation_p.P883S|BCLAF1_ENST00000527536.1_Missense_Mutation_p.P836S|BCLAF1_ENST00000353331.4_Missense_Mutation_p.P834S|BCLAF1_ENST00000529917.1_5'UTR	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	885					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GTCCATTTAGGACTGCTACCT	0.433000													58	293					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96239919	96239919	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:96239919G>A	ENST00000347108.3	-	18	2524	c.2092C>T	c.(2092-2094)Cca>Tca	p.P698S	DZIP1_ENST00000361396.2_Missense_Mutation_p.P679S|DZIP1_ENST00000376829.2_Missense_Mutation_p.P698S|DZIP1_ENST00000361156.3_Missense_Mutation_p.P679S			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	698					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AGTGGGCCTGGGGATGCGTAT	0.572000													18	44					0	0	1	0	0
OR5B2	390190	broad.mit.edu	37	11	58189862	58189862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58189862C>T	ENST00000302581.2	-	1	924	c.873G>A	c.(871-873)agG>agA	p.R291R		NM_001005566.2	NP_001005566.1	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B, member 2	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTTCTCTGTTCCTCAGGCTGT	0.418000													32	62					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131755565	131755565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:131755565C>T	ENST00000368648.3	-	6	583	c.511G>A	c.(511-513)Ggc>Agc	p.G171S	EBF3_ENST00000355311.5_Missense_Mutation_p.G171S	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	171					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		TTTCTATTGCCACAACTTTTC	0.388000													28	104					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33586675	33586675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33586675G>A	ENST00000262873.7	+	33	4365	c.4273G>A	c.(4273-4275)Gaa>Aaa	p.E1425K		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1383						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GAGCAAGTACGAAGCAGATGC	0.637000													17	42					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174243	51174243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51174243G>A	ENST00000440970.1	-	2	2030	c.1599C>T	c.(1597-1599)gtC>gtT	p.V533V	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.V630V|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	630					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTGAGTTGGTGACCATGCCAC	0.637000													16	54					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364116	5364116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5364116G>A	ENST00000300773.2	-	1	693	c.639C>T	c.(637-639)ttC>ttT	p.F213F	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATAGGAGATGAAGATAATCA	0.468000													38	83					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17476486	17476486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17476486G>A	ENST00000252590.4	-	3	849	c.788C>T	c.(787-789)tCg>tTg	p.S263L		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	263						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGCCAATTCCGAGCCCAGGGG	0.602000													11	89					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108076871	108076871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108076871C>T	ENST00000357759.5	+	6	1280	c.866C>T	c.(865-867)tCa>tTa	p.S289L	HHLA2_ENST00000491820.1_Missense_Mutation_p.S289L|HHLA2_ENST00000467562.1_Missense_Mutation_p.S225L|HHLA2_ENST00000467761.1_Missense_Mutation_p.S289L|HHLA2_ENST00000489514.2_Missense_Mutation_p.S289L	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	289	Ig-like V-type 2.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						TCCCGATTCTCATGGAACAAA	0.373000													44	166					0	0	1	0	0
TSPAN18	90139	broad.mit.edu	37	11	44948236	44948236	+	Silent	SNP	G	G	A	rs149091051	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:44948236G>A	ENST00000340160.3	+	8	866	c.627G>A	c.(625-627)acG>acA	p.T209T	TSPAN18_ENST00000520358.2_Silent_p.T209T	NM_130783.4	NP_570139.3	Q96SJ8	TSN18_HUMAN	tetraspanin 18	209						integral to membrane				endometrium(1)|large_intestine(6)|lung(3)	10						GCTGTTACACGGTGATCCTCA	0.587000											OREG0020922	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	123					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117669776	117669776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117669776G>A	ENST00000317775.6	-	22	4081	c.3396C>T	c.(3394-3396)gtC>gtT	p.V1132V	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.V1166V	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1132	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCTTGCTGAGGACCAGCAGAC	0.557000													10	17					0	0	1	0	0
SSUH2	51066	broad.mit.edu	37	3	8675522	8675522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:8675522G>A	ENST00000317371.4	-	11	1328	c.103C>T	c.(103-105)Cct>Tct	p.P35S	SSUH2_ENST00000544814.1_Intron|SSUH2_ENST00000415132.1_Missense_Mutation_p.P35S|SSUH2_ENST00000341795.3_Missense_Mutation_p.P35S					ssu-2 homolog (C. elegans)																		TTCTGGGAAGGGCCTGTGGAC	0.647000													8	14					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186445073	186445073	+	Silent	SNP	G	G	A	rs142183659		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186445073G>A	ENST00000265023.4	+	5	824	c.612G>A	c.(610-612)acG>acA	p.T204T	KNG1_ENST00000287611.2_Silent_p.T204T|KNG1_ENST00000447445.1_Intron|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	204	Cystatin 2.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	TTGTGCAAACGAATTGTTCCA	0.348000													16	97					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17698997	17698997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:17698997G>A	ENST00000399080.2	-	1	709	c.686C>T	c.(685-687)tCa>tTa	p.S229L		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	229										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TAGTACAGATGATGAAATGTT	0.338000													17	69					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52858009	52858009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52858009G>A	ENST00000266041.4	-	10	1279	c.1183C>T	c.(1183-1185)Ccc>Tcc	p.P395S	ITIH4-AS1_ENST00000478366.1_RNA|ITIH4_ENST00000485816.1_Missense_Mutation_p.P395S|ITIH4_ENST00000434759.3_Missense_Mutation_p.P307S|ITIH4_ENST00000406595.1_Missense_Mutation_p.P395S|ITIH4_ENST00000346281.5_Missense_Mutation_p.P395S	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	395	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		ATGCTCCTGGGGTTAGTCTCC	0.542000													15	50					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75136681	75136681	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75136681G>A	ENST00000356357.4	-	14	2272	c.1757C>T	c.(1756-1758)gCc>gTc	p.A586V	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		TATGATTTGGGCCAGGAAAGA	0.542000													32	87					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184632794	184632794	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184632794C>T	ENST00000287546.4	+	26	2386	c.2215C>T	c.(2215-2217)Ccc>Tcc	p.P739S	VPS8_ENST00000446204.2_Missense_Mutation_p.P647S|VPS8_ENST00000437079.3_Missense_Mutation_p.P739S|VPS8_ENST00000436792.2_Missense_Mutation_p.P737S	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	739							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TCGTGCCTATCCCCTTGGTGA	0.428000													22	73					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	782336	782336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:782336G>A	ENST00000540986.1	-	7	1990	c.555C>T	c.(553-555)tcC>tcT	p.S185S	NARFL_ENST00000301694.5_3'UTR|NARFL_ENST00000568545.1_Silent_p.S185S|NARFL_ENST00000562862.1_5'UTR|NARFL_ENST00000251588.2_Silent_p.S287S			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	287					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				GGTCGGGGAGGGAGACGCCCT	0.532000													66	161					0	0	1	0	0
FBLN7	129804	broad.mit.edu	37	2	112944888	112944888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:112944888C>T	ENST00000331203.2	+	8	1396	c.1125C>T	c.(1123-1125)atC>atT	p.I375I	FBLN7_ENST00000409903.1_Intron|FBLN7_ENST00000409667.3_Silent_p.I241I|FBLN7_ENST00000409450.3_Silent_p.I329I	NM_001128165.1|NM_153214.2	NP_001121637.1|NP_694946.2	Q53RD9	FBLN7_HUMAN	fibulin 7	375					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GGTTTGGGATCGTGGGTGGGA	0.642000													56	101					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156741403	156741403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156741403G>A	ENST00000347377.6	+	12	1593	c.1162G>A	c.(1162-1164)Gag>Aag	p.E388K	CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000435847.2_Missense_Mutation_p.E62K|CYFIP2_ENST00000377576.3_Missense_Mutation_p.E388K|CYFIP2_ENST00000318218.6_Missense_Mutation_p.E388K|CYFIP2_ENST00000541131.1_Missense_Mutation_p.E313K|CYFIP2_ENST00000522463.1_Missense_Mutation_p.E192K|CYFIP2_ENST00000521420.1_Missense_Mutation_p.E362K	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	388					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGAGTATCGCGAGCTCTTCGA	0.587000													29	67					0	0	1	0	0
TMEM229B	161145	broad.mit.edu	37	14	67940338	67940338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:67940338G>A	ENST00000357461.2	-	3	712	c.303C>T	c.(301-303)tgC>tgT	p.C101C	TMEM229B_ENST00000557006.1_Silent_p.C101C	NM_182526.2	NP_872332.1	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	101						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5						AGTCCCAGGGGCAGGCGTTGA	0.632000													4	8					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49869412	49869412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49869412G>A	ENST00000331456.2	-	11	1087	c.974C>T	c.(973-975)cCc>cTc	p.P325L	TRAIP_ENST00000469027.1_Missense_Mutation_p.P170L	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	325	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCGGGCTGGGGGAGTATCCAC	0.547000													29	67					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40044087	40044087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40044087G>A	ENST00000373233.3	-	34	6855	c.6678C>T	c.(6676-6678)tcC>tcT	p.S2226S		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2226					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TGGCTCCTGGGGACCCCTCTG	0.597000													8	12					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15688901	15688901	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15688901C>T	ENST00000378076.3	-	12	1504	c.1151G>A	c.(1150-1152)gGg>gAg	p.G384E		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	384					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	p.G384L(1)		NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						ACCGAATCTCCCAAACGTCTC	0.483000													15	51					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3845280	3845280	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3845280C>T	ENST00000400147.2	-	1	79	c.3G>A	c.(1-3)atG>atA	p.M1I	DLGAP1_ENST00000478161.1_Intron|DLGAP1_ENST00000584874.1_Intron|DLGAP1_ENST00000581527.1_Intron|DLGAP1_ENST00000581699.1_Intron|DLGAP1_ENST00000315677.3_Intron|DLGAP1_ENST00000515196.2_Intron|DLGAP1_ENST00000539435.1_Start_Codon_SNP_p.M1I|DLGAP1_ENST00000400145.2_Start_Codon_SNP_p.M1I|DLGAP1_ENST00000400150.3_Intron|DLGAP1_ENST00000400155.1_Intron|DLGAP1_ENST00000400149.3_Intron|DLGAP1_ENST00000534970.1_Intron	NM_001003809.2	NP_001003809.1	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	0					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.M1I(2)		breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				AAATTAAGTTCATTATTCATC	0.368000													15	58					0	0	1	0	0
API5	8539	broad.mit.edu	37	11	43342980	43342980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:43342980C>T	ENST00000378852.3	+	4	470	c.345C>T	c.(343-345)aaC>aaT	p.N115N	API5_ENST00000534600.1_Silent_p.N115N|API5_ENST00000420461.2_Silent_p.N61N|API5_ENST00000531273.1_Silent_p.N115N|API5_ENST00000455725.2_Silent_p.N104N|API5_ENST00000534695.1_Intron	NM_001142930.1|NM_006595.3	NP_001136402.1|NP_006586.1	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	115					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						CAGAATTTAACCTAGTGAACA	0.303000													19	45					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	31498133	31498133	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:31498133C>T	ENST00000520407.1	+	1	863	c.633C>T	c.(631-633)ccC>ccT	p.P211P	NRG1_ENST00000519301.1_Intron	NM_013962.2	NP_039256.2	Q02297	NRG1_HUMAN	neuregulin 1	594	EGF-like.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TCATGGAGCCCGACGCCAACA	0.687000													8	44					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72338188	72338188	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72338188C>T	ENST00000333850.3	+	3	511	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	TPH2_ENST00000546576.1_3'UTR	NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	124	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	TGAGCTCATTCAGTTGCTGAA	0.433000													28	117					0	0	1	0	0
GPR27	2850	broad.mit.edu	37	3	71804292	71804292	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:71804292G>A	ENST00000304411.2	+	1	1092	c.1092G>A	c.(1090-1092)gcG>gcA	p.A364A		NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	364						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		CCACCCAGGCGACCCATCCCT	0.632000													9	21					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58118530	58118530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58118530C>T	ENST00000332854.6	+	3	1857	c.1637C>T	c.(1636-1638)cCt>cTt	p.P546L	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGAGAAAGGCCTTATGAGTGC	0.448000													11	136					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65180891	65180891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:65180891G>A	ENST00000310045.7	-	2	2458	c.985C>T	c.(985-987)Ctt>Ttt	p.L329F	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	319						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				CCAGGTAAAAGGGTGGCATAA	0.383000													15	123					0	0	1	0	0
SLC17A3	10786	broad.mit.edu	37	6	25850805	25850805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25850805C>T	ENST00000397060.4	-	8	984	c.875G>A	c.(874-876)aGa>aAa	p.R292K	SLC17A3_ENST00000361703.6_Missense_Mutation_p.R214K|SLC17A3_ENST00000360657.3_Missense_Mutation_p.R214K	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	214					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						GGGTAGAGATCTGAGCATAGC	0.423000													20	82					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032418	142032418	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142032418C>T	ENST00000547918.2	+	0	271																											ATCGGGGCTTCCCCGTGATCG	0.552000													14	16					0	0	1	0	0
ZNF391	346157	broad.mit.edu	37	6	27368311	27368311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:27368311C>T	ENST00000244576.4	+	3	707	c.162C>T	c.(160-162)ttC>ttT	p.F54F		NM_001076781.1	NP_001070249.1	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(6)|lung(7)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	21						AAGAAATTTTCACAGGGGAGG	0.428000													26	77					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57646757	57646757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57646757G>A	ENST00000269834.1	-	5	1333	c.948C>T	c.(946-948)ttC>ttT	p.F316F		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACTTGTAAATGAAAGCCTTTC	0.403000													52	128					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152518823	152518823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152518823C>T	ENST00000427231.2	-	46	5998	c.5796G>A	c.(5794-5796)atG>atA	p.M1932I	NEB_ENST00000409198.1_Missense_Mutation_p.M1932I|NEB_ENST00000397345.3_Missense_Mutation_p.M1932I|NEB_ENST00000604864.1_Missense_Mutation_p.M1932I|NEB_ENST00000172853.10_Missense_Mutation_p.M1932I|NEB_ENST00000603639.1_Missense_Mutation_p.M1932I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1932					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAATGCCCTTCATGAAGTCAG	0.433000													16	120					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40364092	40364092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40364092G>A	ENST00000221347.6	-	31	14557	c.14550C>T	c.(14548-14550)gcC>gcT	p.A4850A		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4850						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CACAGCCTGTGGCATGACAGG	0.647000													12	51					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8069746	8069746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:8069746C>T	ENST00000332175.8	+	8	2232	c.1195C>T	c.(1195-1197)Cgc>Tgc	p.R399C	PTPRM_ENST00000400060.4_Missense_Mutation_p.R399C|PTPRM_ENST00000444013.1_Missense_Mutation_p.R186C|PTPRM_ENST00000578571.1_3'UTR|PTPRM_ENST00000580170.1_Missense_Mutation_p.R399C|PTPRM_ENST00000400053.4_Missense_Mutation_p.R337C	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	399	Fibronectin type-III 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				AATCACTATCCGCTGGGAGCC	0.423000													18	48					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32585567	32585567	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:32585567C>T	ENST00000341377.5	+	6	1120	c.603C>T	c.(601-603)gaC>gaT	p.D201D	NRG1_ENST00000287840.5_Silent_p.D201D|NRG1_ENST00000287842.3_Silent_p.D201D|NRG1_ENST00000523079.1_Silent_p.D201D|NRG1_ENST00000338921.4_Silent_p.D201D|NRG1_ENST00000520502.2_Silent_p.D256D|NRG1_ENST00000287845.5_Silent_p.D167D|NRG1_ENST00000539990.1_Silent_p.D47D|NRG1_ENST00000521670.1_Silent_p.D201D|NRG1_ENST00000405005.2_Silent_p.D201D|NRG1_ENST00000519301.1_Silent_p.D146D|NRG1_ENST00000520407.1_Silent_p.D382D|NRG1_ENST00000356819.4_Silent_p.D201D			Q02297	NRG1_HUMAN	neuregulin 1	201	EGF-like.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGGTGAAAGACCTTTCAAACC	0.423000													25	92					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100380924	100380924	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100380924G>A	ENST00000262233.6	+	15	1781	c.1642G>A	c.(1642-1644)Gga>Aga	p.G548R	EML1_ENST00000334192.4_Missense_Mutation_p.G567R|EML1_ENST00000327921.9_Missense_Mutation_p.G536R	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	548						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TGAGCTCTGGGGACTGGCCAT	0.537000													6	46					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101680176	101680176	+	Missense_Mutation	SNP	C	C	T	rs147399996		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101680176C>T	ENST00000261637.4	+	5	578	c.404C>T	c.(403-405)tCg>tTg	p.S135L		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	135					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding	p.S135L(1)		NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						ACTATCACCTCGATCCTGGAG	0.423000													84	199					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220107272	220107272	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220107272G>A	ENST00000295759.7	-	5	728	c.415C>T	c.(415-417)Cga>Tga	p.R139*	GLB1L_ENST00000356283.3_Nonsense_Mutation_p.R139*|GLB1L_ENST00000392089.2_Nonsense_Mutation_p.R139*|GLB1L_ENST00000409640.1_Nonsense_Mutation_p.R139*			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	139					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAGGTTTTCGAAGCAACCAG	0.443000													48	105					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084910	53084910	+	Missense_Mutation	SNP	G	G	A	rs140839383		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:53084910G>A	ENST00000276480.7	-	10	1194	c.511C>T	c.(511-513)Cat>Tat	p.H171Y		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	171						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCATCAGAATGAATCAGAAAG	0.403000													31	55					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83591047	83591047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83591047C>T	ENST00000265362.3	-	17	2270	c.1956G>A	c.(1954-1956)gtG>gtA	p.V652V	SEMA3A_ENST00000436949.1_Silent_p.V652V	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	652	Ig-like C2-type.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						ACCCATGTTCCACCGCATGGC	0.438000													28	82					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202060586	202060586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202060586C>T	ENST00000286186.6	+	5	1034	c.599C>T	c.(598-600)cCt>cTt	p.P200L	CASP10_ENST00000313728.7_Missense_Mutation_p.P200L|CASP10_ENST00000272879.5_Missense_Mutation_p.P200L|CASP10_ENST00000346817.5_Missense_Mutation_p.P200L|CASP10_ENST00000448480.1_Missense_Mutation_p.P200L|CASP10_ENST00000374650.3_Missense_Mutation_p.P200L|CASP10_ENST00000360132.3_Missense_Mutation_p.P200L|CASP10_ENST00000492363.1_3'UTR	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	200					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						GTGACACCTCCTGTAGACAAG	0.443000													72	166					0	0	1	0	0
CYP2S1	29785	broad.mit.edu	37	19	41704713	41704713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41704713G>A	ENST00000310054.4	+	5	970	c.754G>A	c.(754-756)Gtg>Atg	p.V252M	CYP2S1_ENST00000542619.1_Intron	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	252					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						AGTCCGGCAGGTGCAGCAGCA	0.642000													29	64					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6477836	6477836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6477836G>A	ENST00000525074.1	-	6	1514	c.1120C>T	c.(1120-1122)Ctt>Ttt	p.L374F	TRIM3_ENST00000359518.3_Missense_Mutation_p.L374F|TRIM3_ENST00000529058.1_5'UTR|TRIM3_ENST00000536344.1_Missense_Mutation_p.L255F|TRIM3_ENST00000345851.3_Missense_Mutation_p.L374F|TRIM3_ENST00000537602.1_Missense_Mutation_p.L296F	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	374					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCACCGGAAGGCGCGTGCCG	0.632000													13	41					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65490231	65490231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65490231C>T	ENST00000261883.4	-	9	2559	c.2393G>A	c.(2392-2394)aGt>aAt	p.S798N		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	798					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						TGTGATGACACTGTCAAAGCG	0.587000													16	135					0	0	1	0	0
C1orf64	149563	broad.mit.edu	37	1	16332591	16332591	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16332591A>G	ENST00000329454.2	+	2	328	c.260A>G	c.(259-261)gAa>gGa	p.E87G		NM_178840.2	NP_849162.1	Q8NEQ6	CA064_HUMAN	chromosome 1 open reading frame 64	87										breast(2)|endometrium(1)|lung(3)	6		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTGTGGGGAAAACTGGCCC	0.642000													55	98					0	0	1	0	0
LAMP1	3916	broad.mit.edu	37	13	113973849	113973849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113973849C>T	ENST00000332556.4	+	5	822	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S	LAMP1_ENST00000397181.3_Missense_Mutation_p.P157S	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	210	Hinge.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			CAGCCCCTCGCCCTCACCCGT	0.652000													16	52					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61513219	61513219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61513219G>A	ENST00000266070.4	-	16	4414	c.4089C>T	c.(4087-4089)atC>atT	p.I1363I	DIDO1_ENST00000395343.1_Silent_p.I1363I	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1363					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					ACTGCTGGACGATCGGATCTA	0.622000													57	128					0	0	1	0	0
AK1	203	broad.mit.edu	37	9	130630339	130630339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130630339G>A	ENST00000373176.1	-	7	685	c.533C>T	c.(532-534)tCc>tTc	p.S178F	AK1_ENST00000373156.1_Missense_Mutation_p.S178F|AK1_ENST00000223836.10_Missense_Mutation_p.S194F|RP11-203J24.9_ENST00000476274.2_RNA	NM_000476.2	NP_000467.1	P00568	KAD1_HUMAN	adenylate kinase 1	178					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding			endometrium(1)|prostate(1)	2						ACTGTCCACGGAGCCCTCAGC	0.677000													27	50					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966705	41966705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41966705G>A	ENST00000298919.7	+	10	1732	c.1344G>A	c.(1342-1344)cgG>cgA	p.R448R	PDZRN4_ENST00000402685.2_Silent_p.R708R|PDZRN4_ENST00000539469.2_Silent_p.R450R			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	708	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding	p.R450R(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAGGATTCCGGAATTATAACA	0.448000													7	120					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56935685	56935685	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56935685C>T	ENST00000333201.9	+	5	1868	c.1658C>T	c.(1657-1659)cCc>cTc	p.P553L	ZNF583_ENST00000585612.1_Intron|ZNF583_ENST00000291598.7_Missense_Mutation_p.P553L	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	553					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		ctttcctctccctcaccctcc	0.423000													13	23					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61040427	61040427	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61040427G>A	ENST00000252997.2	-	6	1068	c.1007C>T	c.(1006-1008)cCa>cTa	p.P336L		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	336					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			AGGGCACACTGGGGACGCCAG	0.672000													7	19					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404084	124404084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:124404084G>A	ENST00000303921.2	-	1	1597	c.947C>T	c.(946-948)cCg>cTg	p.P316L		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	316						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GATGACCAGCGGAAGGCAGAA	0.532000													63	134					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207881565	207881565	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207881565G>A	ENST00000508064.2	+	10	1431	c.1371G>A	c.(1369-1371)tcG>tcA	p.S457S	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	457	Sushi 7.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						GTATCCTCTCGGGCAATACTG	0.453000													40	183					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169535587	169535587	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169535587T>C	ENST00000449804.2	+	2	869	c.824T>C	c.(823-825)cTc>cCc	p.L275P	FOXI1_ENST00000306268.6_Missense_Mutation_p.L370P	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	370					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTGGTGTCCTCTACCCCAGG	0.572000									Pendred syndrome				35	86					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126240774	126240774	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126240774G>A	ENST00000394329.3	+	1	3221	c.3208G>A	c.(3208-3210)Gtt>Att	p.V1070I		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1070	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGTTTTAATGGTTGTTGCTTC	0.373000													68	172					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901844	51901844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:51901844G>A	ENST00000268919.4	+	1	1606	c.1450G>A	c.(1450-1452)Gct>Act	p.A484T		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	484					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ATGTATTCTGGCTTTGGGTCA	0.507000													8	37					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21213314	21213314	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21213314C>T	ENST00000574002.1	-	13	1800	c.1318G>A	c.(1318-1320)Gaa>Aaa	p.E440K	ZP2_ENST00000219593.4_Missense_Mutation_p.E440K|AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Missense_Mutation_p.E440K			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	440	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		GCATGTATTTCGTTTTCATAG	0.393000													32	113					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008510	120008510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120008510C>T	ENST00000341846.5	-	1	651	c.230G>A	c.(229-231)cGa>cAa	p.R77Q		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	77					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R77L(2)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GATGATGGGTCGCCGCCACTC	0.637000													81	189					0	0	1	0	0
OPN4	94233	broad.mit.edu	37	10	88417801	88417801	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88417801C>T	ENST00000372071.2	+	4	563	c.336C>T	c.(334-336)ctC>ctT	p.L112L	OPN4_ENST00000241891.5_Silent_p.L101L	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	101					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						GCAGAAGCCTCCGGACACCTG	0.562000													7	92					0	0	1	0	0
LEKR1	389170	broad.mit.edu	37	3	156711020	156711020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:156711020C>T	ENST00000470811.1	+	10	1486	c.151C>T	c.(151-153)Ctt>Ttt	p.L51F	LEKR1_ENST00000356539.4_Missense_Mutation_p.L355F			D3DNK7	D3DNK7_HUMAN	leucine, glutamate and lysine rich 1	64										breast(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	11			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AACCAAAACTCTTCTGAATCA	0.323000													10	112					0	0	1	0	0
OR2T8	343172	broad.mit.edu	37	1	248085211	248085211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248085211G>A	ENST00000319968.4	+	1	892	c.892G>A	c.(892-894)Gcc>Acc	p.A298T		NM_001005522.1	NP_001005522.1	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T, member 8	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(20)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGTGAAGGGAGCCCTGACAAG	0.453000													51	129					0	0	1	0	0
KLF4	9314	broad.mit.edu	37	9	110249798	110249798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:110249798G>A	ENST00000374672.4	-	3	1350	c.877C>T	c.(877-879)Cct>Tct	p.P293S		NM_004235.4	NP_004226.3	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	293	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(5)|large_intestine(1)|lung(3)|pancreas(1)|prostate(2)	16						TTGCTGAGAGGGGGTCCAGCG	0.701000													4	17					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74082501	74082501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74082501G>A	ENST00000443185.2	-	7	3731	c.3414C>T	c.(3412-3414)tcC>tcT	p.S1138S	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	1138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GGGCGTCTGCGGAGGTGGTAT	0.527000													6	16					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423265	56423265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56423265G>A	ENST00000588751.1	-	5	1942	c.1918C>T	c.(1918-1920)Cac>Tac	p.H640Y	NLRP13_ENST00000342929.3_Missense_Mutation_p.H640Y			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	640							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TGTAGGCAGTGAAAAAGTCGT	0.423000													40	79					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216837	21216837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21216837C>T	ENST00000380216.1	-	1	473	c.468G>A	c.(466-468)ggG>ggA	p.G156G		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	156					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TGTATTTCTTCCCCATCAGAT	0.438000													44	403					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75329450	75329450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75329450G>A	ENST00000556489.2	-	1	1087	c.1088C>T	c.(1087-1089)cCt>cTt	p.P363L	PROX2_ENST00000445876.1_Missense_Mutation_p.P363L|PROX2_ENST00000556084.2_Intron	NM_001243007.1	NP_001229936.1	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	363					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GTCCTGGGGAGGACTGCTACT	0.537000													15	31					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72955525	72955525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:72955525C>T	ENST00000264839.7	+	11	2089	c.2089C>T	c.(2089-2091)Ccc>Tcc	p.P697S	RIMS1_ENST00000348717.5_Missense_Mutation_p.P697S|RIMS1_ENST00000517827.1_Missense_Mutation_p.P156S|RIMS1_ENST00000517960.1_Missense_Mutation_p.P697S|RIMS1_ENST00000491071.2_Missense_Mutation_p.P697S|RIMS1_ENST00000522291.1_Missense_Mutation_p.P697S|RIMS1_ENST00000401910.3_Missense_Mutation_p.P171S|RIMS1_ENST00000425662.2_Missense_Mutation_p.P90S|RIMS1_ENST00000523963.1_Missense_Mutation_p.P171S|RIMS1_ENST00000521978.1_Missense_Mutation_p.P697S|RIMS1_ENST00000520567.1_Missense_Mutation_p.P697S|RIMS1_ENST00000518273.1_Missense_Mutation_p.P697S			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	697					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TAGTGACATTCCCCGGATTCC	0.393000													22	45					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67016572	67016572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67016572G>A	ENST00000340001.4	-	19	2768	c.2557C>T	c.(2557-2559)Cgc>Tgc	p.R853C	ABCA9_ENST00000453985.2_Missense_Mutation_p.R853C|ABCA9_ENST00000370732.2_Missense_Mutation_p.R853C	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	853					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TTTAGGAAGCGAACTTTTGCT	0.398000													49	116					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183196718	183196718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183196718G>A	ENST00000264144.4	+	10	1419	c.1354G>A	c.(1354-1356)Gat>Aat	p.D452N	LAMC2_ENST00000493293.1_Missense_Mutation_p.D452N	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	452	Laminin EGF-like 5.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						TTTCTACAACGATCCGCACGA	0.557000													61	141					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8692525	8692525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8692525G>A	ENST00000299663.3	-	2	221	c.56C>T	c.(55-57)tCc>tTc	p.S19F	CLEC4E_ENST00000545274.1_Missense_Mutation_p.S19F|CLEC4E_ENST00000446457.2_Missense_Mutation_p.S19F	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	19						integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					GAACATTTGGGAAGAGAAGCA	0.403000													38	144					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147381126	147381126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:147381126G>A	ENST00000240986.4	+	2	1097	c.1044G>A	c.(1042-1044)gaG>gaA	p.E348E	GJA8_ENST00000369235.1_Silent_p.E348E	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	348					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					AGGTGGGAGAGAAGAAGGAGG	0.637000													3	10					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644533	169644533	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169644533G>A	ENST00000428432.2	+	6	872	c.483G>A	c.(481-483)caG>caA	p.Q161Q	SAMD7_ENST00000335556.3_Silent_p.Q161Q	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	161										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GAAACCTTCAGGGAAACCCCA	0.562000													49	83					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47031040	47031040	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47031040C>T	ENST00000450053.3	+	6	692	c.513C>T	c.(511-513)ttC>ttT	p.F171F	NBEAL2_ENST00000383740.2_5'UTR|NBEAL2_ENST00000292309.5_Silent_p.F171F	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	171							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		AATACAAGTTCCCTCCTGCTG	0.622000													5	12					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207025	58207025	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58207025C>T	ENST00000377918.3	+	1	371	c.345C>T	c.(343-345)atC>atT	p.I115I		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	115	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ACAAGGAGATCTGCATGATCA	0.592000													14	26					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99514193	99514193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:99514193G>A	ENST00000261037.3	+	5	1828	c.1448G>A	c.(1447-1449)gGa>gAa	p.G483E	COL8A1_ENST00000273342.4_Missense_Mutation_p.G483E	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	483	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGACCTAAGGGAGAGCCAGGA	0.627000													4	9					0	0	1	0	0
CRHBP	1393	broad.mit.edu	37	5	76249004	76249004	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76249004C>T	ENST00000274368.4	+	1	467	c.45C>T	c.(43-45)ttC>ttT	p.F15F	CRHBP_ENST00000506501.1_Silent_p.F15F	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	15					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		TTCTCATCTTCCTGACGGCTC	0.582000													16	44					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125512489	125512489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125512489C>T	ENST00000373684.1	+	1	471	c.471C>T	c.(469-471)atC>atT	p.I157I	OR1L6_ENST00000304720.2_Silent_p.I121I			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						CTATGGCCATCGACCGGCTGG	0.527000													20	143					0	0	1	0	0
EFCAB11	90141	broad.mit.edu	37	14	90397920	90397920	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90397920G>A	ENST00000316738.7	-	5	403	c.375C>T	c.(373-375)ccC>ccT	p.P125P	EFCAB11_ENST00000555872.1_Silent_p.P101P|EFCAB11_ENST00000550103.2_5'UTR|EFCAB11_ENST00000267544.9_Silent_p.P62P|EFCAB11_ENST00000556005.1_Silent_p.P101P|EFCAB11_ENST00000556609.1_Silent_p.P77P|EFCAB11_ENST00000538485.2_Silent_p.P125P|RP11-33N16.3_ENST00000555070.1_RNA	NM_145231.2	NP_660274.1	Q9BUY7	EFC11_HUMAN	EF-hand calcium binding domain 11	125	EF-hand 2.						calcium ion binding			large_intestine(1)|lung(1)	2						CCGGTAATTTGGGAGCCACCT	0.333000													54	116					0	0	1	0	0
ZNF599	148103	broad.mit.edu	37	19	35251398	35251398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35251398G>A	ENST00000329285.7	-	4	681	c.308C>T	c.(307-309)tCt>tTt	p.S103F		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TTCCTGGAAAGAGGATTCCTC	0.428000													30	65					0	0	1	0	0
TMEM19	55266	broad.mit.edu	37	12	72092736	72092736	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72092736T>C	ENST00000266673.5	+	5	1288	c.694T>C	c.(694-696)Ttt>Ctt	p.F232L	RP11-293I14.2_ENST00000548802.1_3'UTR|TMEM19_ENST00000549735.1_Missense_Mutation_p.F232L	NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	232						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		TGGTGGTACCTTTGTGGGCAT	0.453000													61	104					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49898976	49898976	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49898976C>T	ENST00000477224.1	-	5	815	c.337G>A	c.(337-339)Gac>Aac	p.D113N	CAMKV_ENST00000463537.1_Missense_Mutation_p.D113N|CAMKV_ENST00000498324.1_5'UTR|CAMKV_ENST00000296471.7_Missense_Mutation_p.D113N|CAMKV_ENST00000467248.1_Missense_Mutation_p.D38N|CAMKV_ENST00000466940.1_Intron|CAMKV_ENST00000488336.1_Missense_Mutation_p.D113N			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	113	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TAGCCCTGGTCCAGGATCCAG	0.612000													20	60					0	0	1	0	0
COPS2	9318	broad.mit.edu	37	15	49431756	49431756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:49431756G>A	ENST00000388901.5	-	4	414	c.341C>T	c.(340-342)tCt>tTt	p.S114F	COPS2_ENST00000542928.1_Missense_Mutation_p.S50F|COPS2_ENST00000299259.6_Missense_Mutation_p.S114F	NM_001143887.1|NM_004236.3	NP_001137359.1|NP_004227.1	P61201	CSN2_HUMAN	COP9 signalosome subunit 2	114					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(2)	18		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		ATCAAGAATAGAATTAATGGA	0.328000													34	89					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5282933	5282933	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5282933G>A	ENST00000546004.1	-	3	1154	c.908C>T	c.(907-909)aCt>aTt	p.T303I	PROKR2_ENST00000217270.3_Missense_Mutation_p.T303I			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	303						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CACGAACACAGTGGGGAAGAA	0.552000										HNSCC(71;0.22)			44	65					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127622432	127622432	+	Silent	SNP	C	C	T	rs28763928		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127622432C>T	ENST00000508053.1	-	61	7964	c.6990G>A	c.(6988-6990)agG>agA	p.R2330R	FBN2_ENST00000262464.4_Silent_p.R2330R			P35556	FBN2_HUMAN	fibrillin 2	2330	EGF-like 39; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTCCATCGGGCCTTCGGGCCA	0.512000													13	65					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91795689	91795689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91795689C>T	ENST00000394232.1	+	4	1193	c.723C>T	c.(721-723)atC>atT	p.I241I	SV2B_ENST00000330276.4_Silent_p.I241I|SV2B_ENST00000545111.2_Silent_p.I90I	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	241					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GGCTGGGCATCTTCTGGATGA	0.532000													29	76					0	0	1	0	0
CALB2	794	broad.mit.edu	37	16	71408680	71408680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71408680G>A	ENST00000302628.4	+	3	281	c.204G>A	c.(202-204)atG>atA	p.M68I	CALB2_ENST00000349553.5_Missense_Mutation_p.M68I	NM_001740.4	NP_001731.2	P22676	CALB2_HUMAN	calbindin 2	68	EF-hand 2.						calcium ion binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18		Ovarian(137;0.125)				GAGAAAAGATGAAGGAGTTCA	0.478000													16	50					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197889254	197889254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197889254C>T	ENST00000367390.3	+	3	327	c.300C>T	c.(298-300)ctC>ctT	p.L100L	LHX9_ENST00000367391.1_Silent_p.L100L|LHX9_ENST00000367387.4_Silent_p.L109L|LHX9_ENST00000561173.1_Silent_p.L115L|LHX9_ENST00000337020.2_Silent_p.L109L	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	109	LIM zinc-binding 1.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						AGTCCGAGCTCACCTGCTTTG	0.557000													21	328					0	0	1	0	0
TRGV8	6982	broad.mit.edu	37	7	38370174	38370174	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38370174C>T	ENST00000390343.2	-	0	237																											ACAGGAAGATCACAAGTGATT	0.502000													35	67					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76427474	76427474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76427474G>A	ENST00000357063.3	+	29	6027	c.4767G>A	c.(4765-4767)ccG>ccA	p.P1589P	LMO7_ENST00000341547.4_Silent_p.P1255P|LMO7_ENST00000377534.3_Silent_p.P1589P|LMO7_ENST00000321797.8_Silent_p.P1304P|LMO7_ENST00000465261.2_Silent_p.P1304P|LMO7_ENST00000526202.1_Silent_p.P1181P			Q8WWI1	LMO7_HUMAN	LIM domain 7	1589						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		CCCCCACCCCGAGAAGCCATT	0.577000													17	72					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147131157	147131157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:147131157C>T	ENST00000282928.4	+	3	1892	c.1163C>T	c.(1162-1164)tCg>tTg	p.S388L		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	388	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						GAATCCTCCTCGCAGGGCTCG	0.627000													29	88					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240286601	240286601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240286601G>A	ENST00000319653.9	+	2	1968	c.1738G>A	c.(1738-1740)Gaa>Aaa	p.E580K		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	580					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTGCTTCAGGGAACCGTGTAA	0.493000													30	77					0	0	1	0	0
LDLRAD2	401944	broad.mit.edu	37	1	22140991	22140991	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22140991C>T	ENST00000344642.2	+	2	373	c.186C>T	c.(184-186)acC>acT	p.T62T	LDLRAD2_ENST00000543870.1_Silent_p.T62T	NM_001013693.2	NP_001013715.2	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain containing 2	62						integral to membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)	6		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		CTCCGGACACCGACTGCGGGC	0.726000													8	47					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	94797	94797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:94797C>T	ENST00000309812.4	-	2	175	c.113G>A	c.(112-114)gGg>gAg	p.G38E	TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000332708.5_Intron|TUBB8_ENST00000447903.2_5'UTR	NM_177987.2	NP_817124.1	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	38					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GTGGCTGTCCCCGTGGTAGGT	0.647000													5	8					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101765653	101765653	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101765653C>T	ENST00000334289.3	-	8	1399	c.804G>A	c.(802-804)acG>acA	p.T268T		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	268	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		TAAAAAATCTCGTTTCATCCT	0.313000													20	55					0	0	1	0	0
CHST1	8534	broad.mit.edu	37	11	45671761	45671761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:45671761C>T	ENST00000308064.2	-	4	1383	c.713G>A	c.(712-714)gGc>gAc	p.G238D		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	238					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		AGCCAGAATGCCGCGGGGGTC	0.652000													16	60					0	0	1	0	0
SNTB1	6641	broad.mit.edu	37	8	121823712	121823712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121823712C>T	ENST00000395601.3	-	2	786	c.372G>A	c.(370-372)ggG>ggA	p.G124G	SNTB1_ENST00000519177.1_5'UTR|SNTB1_ENST00000517992.1_Silent_p.G124G	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	124	PDZ.|PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGATGCTGATCCCCAGCCCGC	0.637000													15	31					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810601	123810601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123810601C>T	ENST00000307033.2	+	1	352	c.278C>T	c.(277-279)tCc>tTc	p.S93F		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCTACCATTTCCTTTGGTGGA	0.468000													29	93					0	0	1	0	0
KRT28	162605	broad.mit.edu	37	17	38953243	38953243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38953243G>A	ENST00000306658.7	-	5	968	c.903C>T	c.(901-903)ttC>ttT	p.F301F		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	301	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				GGCTCCGGGCGAAAGTGGCTG	0.657000													22	50					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124345586	124345586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124345586C>T	ENST00000368909.3	+	16	1576	c.1470C>T	c.(1468-1470)tcC>tcT	p.S490S	DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368955.3_Silent_p.S480S|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000344338.3_Silent_p.S480S|DMBT1_ENST00000338354.3_Silent_p.S490S	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	490					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GATCTGAATCCAGTTTGGCCC	0.542000													119	312					0	0	1	0	0
SEMA4D	10507	broad.mit.edu	37	9	92006331	92006331	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:92006331C>T	ENST00000450295.1	-	9	1399		c.e9-1		SEMA4D_ENST00000356444.2_Splice_Site|SEMA4D_ENST00000339861.4_Splice_Site|SEMA4D_ENST00000438547.2_Splice_Site|SEMA4D_ENST00000455551.2_Splice_Site|SEMA4D_ENST00000422704.2_Splice_Site|SEMA4D_ENST00000420987.1_Splice_Site|SEMA4D_ENST00000343780.4_Splice_Site			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D						anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						AAACTAGGCTCTGCAGAGAGA	0.582000													13	57					0	0	1	0	0
HOXA5	3202	broad.mit.edu	37	7	27182802	27182802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27182802C>T	ENST00000222726.3	-	1	485	c.425G>A	c.(424-426)gGg>gAg	p.G142E	HOXA-AS3_ENST00000518848.1_RNA|HOXA-AS3_ENST00000521197.1_RNA|HOXA3_ENST00000467897.2_Intron	NM_019102.3	NP_061975.2	P20719	HXA5_HUMAN	homeobox A5	142					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(12)|skin(1)	16						CGTGCCAACCCCCTCTCTGCT	0.736000													24	60					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166870271	166870271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166870271G>A	ENST00000423058.2	-	18	3705	c.3688C>T	c.(3688-3690)Ctt>Ttt	p.L1230F	SCN1A_ENST00000375405.3_Missense_Mutation_p.L1219F|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.L1230F|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.L1202F	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1230						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCACTACTAAGGAGAATCATG	0.378000													25	66					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409824	56409824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56409824C>T	ENST00000544374.1	-	1	123	c.95G>A	c.(94-96)gGa>gAa	p.G32E	OR5AP2_ENST00000302981.1_Missense_Mutation_p.G31E			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						AAAGAGGACTCCTTGTAGATC	0.413000													9	95					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124988179	124988179	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124988179G>A	ENST00000522917.1	+	9	931	c.725G>A	c.(724-726)tGg>tAg	p.W242*	FER1L6_ENST00000399018.1_Nonsense_Mutation_p.W242*	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	242	C2 2.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAGAGACCGTGGGCCAGATTC	0.443000													65	121					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34111984	34111984	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34111984C>T	ENST00000389232.4	+	77	10804	c.10734C>T	c.(10732-10734)acC>acT	p.T3578T	RYR3_ENST00000415757.3_Silent_p.T3573T	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3578					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTTTGTACACCTCCTATTCCA	0.353000													135	331					0	0	1	0	0
NR2E3	10002	broad.mit.edu	37	15	72104690	72104690	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72104690G>A	ENST00000398840.2	+	0	776							Q9Y5X4	NR2E3_HUMAN	nuclear receptor subfamily 2, group E, member 3						phototransduction|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|endometrium(1)|lung(1)	3						TGAGAATATTGATGTCACCAG	0.582000													46	138					0	0	1	0	0
HOXB13	10481	broad.mit.edu	37	17	46805705	46805705	+	Missense_Mutation	SNP	C	C	T	rs138213197	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46805705C>T	ENST00000290295.7	-	1	835	c.251G>A	c.(250-252)gGa>gAa	p.G84E		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	84					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GTACCCGCCTCCAAAGTAACC	0.687000													12	70					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13741672	13741672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:13741672C>T	ENST00000383314.2	+	7	1196	c.956C>T	c.(955-957)cCc>cTc	p.P319L	RNMT_ENST00000592764.1_Missense_Mutation_p.P319L|RNMT_ENST00000589866.1_Missense_Mutation_p.P319L|RNMT_ENST00000262173.3_Missense_Mutation_p.P319L|RNMT_ENST00000543302.2_Missense_Mutation_p.P319L|RNMT_ENST00000535051.1_Missense_Mutation_p.P77L			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	319					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						GGTACTACTCCCAATAGCTTT	0.343000													17	89					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602378	138602378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138602378G>A	ENST00000440172.1	-	2	2042	c.1994C>T	c.(1993-1995)cCc>cTc	p.P665L	KIAA1549_ENST00000422774.1_Missense_Mutation_p.P665L|KIAA1549_ENST00000242365.4_Missense_Mutation_p.P615L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	665	Ser-rich.					integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CTCAACCAAGGGAGAAAAAGA	0.502000			O	BRAF	pilocytic astrocytoma								3	27					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11008349	11008349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11008349C>T	ENST00000377004.4	-	12	1842	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K	C1orf127_ENST00000377008.4_Missense_Mutation_p.E448K	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	466										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GAGCACGTTTCCTGGGGCTCT	0.662000													38	96					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103566796	103566796	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103566796C>T	ENST00000380069.3	+	1	316	c.240C>T	c.(238-240)tcC>tcT	p.S80S		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	80										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						GGCGAAGCTCCTGCTCCCTGT	0.672000													13	25					0	0	1	0	0
RGR	5995	broad.mit.edu	37	10	86008723	86008723	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:86008723G>A	ENST00000372092.3	+	3	249	c.244G>A	c.(244-246)Ggg>Agg	p.G82R	RGR_ENST00000358110.5_Silent_p.Q94Q|RGR_ENST00000359452.4_Silent_p.Q98Q			P47804	RGR_HUMAN	retinal G protein coupled receptor	0					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	17						ACGGCTTCCAGGGCTTTGTGA	0.632000													10	56					0	0	1	0	0
C14orf166	51637	broad.mit.edu	37	14	52458057	52458057	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52458057C>T	ENST00000261700.3	+	2	249	c.84C>T	c.(82-84)ttC>ttT	p.F28F	C14orf166_ENST00000556760.1_Silent_p.F28F	NM_016039.2	NP_057123.1	Q9Y224	CN166_HUMAN	chromosome 14 open reading frame 166	28						microtubule organizing center|nucleus|perinuclear region of cytoplasm|tRNA-splicing ligase complex	identical protein binding			endometrium(1)|large_intestine(3)|lung(2)	6	Breast(41;0.0639)|all_epithelial(31;0.101)					TTAGAAACTTCATCGTTTGGC	0.353000													5	61					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211541795	211541795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211541795C>T	ENST00000233072.5	+	37	4535	c.4339C>T	c.(4339-4341)Cat>Tat	p.H1447Y	CPS1_ENST00000451903.2_Missense_Mutation_p.H996Y|CPS1_ENST00000430249.2_Missense_Mutation_p.H1453Y	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1447					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity	p.H1447D(1)|p.H1453D(1)		breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TAAATTTGTCCATGATAATTA	0.378000													37	148					0	0	1	0	0
REEP4	80346	broad.mit.edu	37	8	21996484	21996484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:21996484G>A	ENST00000306306.3	-	6	976	c.508C>T	c.(508-510)Ccc>Tcc	p.P170S	REEP4_ENST00000334530.5_Intron|REEP4_ENST00000523293.1_Missense_Mutation_p.P170S	NM_025232.2	NP_079508.2	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	170						integral to membrane				kidney(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	7				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		AGGTAGAGGGGGTCATGGTAG	0.677000													8	21					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157959834	157959834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157959834C>T	ENST00000389413.3	-	6	802	c.699G>A	c.(697-699)gtG>gtA	p.V233V	PTPRN2_ENST00000389416.4_Silent_p.V216V|PTPRN2_ENST00000404321.2_Silent_p.V256V|PTPRN2_ENST00000389418.4_Silent_p.V233V|PTPRN2_ENST00000409483.1_Silent_p.V195V	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	233						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CACCACTGTCCACCTTAGGGC	0.697000													18	36					0	0	1	0	0
WFDC3	140686	broad.mit.edu	37	20	44405749	44405749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44405749C>T	ENST00000243938.4	-	5	541	c.458G>A	c.(457-459)gGc>gAc	p.G153D	WFDC3_ENST00000372632.2_Intron|WFDC3_ENST00000481847.1_Intron|WFDC3_ENST00000372630.2_Intron	NM_080614.1	NP_542181.1	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3	153	WAP 3.					extracellular region	serine-type endopeptidase inhibitor activity			endometrium(1)|large_intestine(3)|prostate(1)	5		Myeloproliferative disorder(115;0.0122)				GCGGCCACAGCCGGTGCTGCA	0.557000													19	33					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045156	87045156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87045156C>T	ENST00000370563.3	+	13	2284	c.2242C>T	c.(2242-2244)Ccc>Tcc	p.P748S	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	748						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CCCAAGCCTTCCCTTGCCTGA	0.468000													67	134					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37323488	37323488	+	Missense_Mutation	SNP	C	C	T	rs140013994		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37323488C>T	ENST00000361924.2	+	3	576	c.202C>T	c.(202-204)Cgg>Tgg	p.R68W	GOLGA4_ENST00000444882.1_Missense_Mutation_p.R68W|GOLGA4_ENST00000435830.2_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.R90W	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	68					Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GCTCCAGCTCCGGGTGCCCTC	0.443000													14	117					0	0	1	0	0
TSPAN13	27075	broad.mit.edu	37	7	16817503	16817503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:16817503C>T	ENST00000262067.4	+	4	826	c.393C>T	c.(391-393)ttC>ttT	p.F131F	TSPAN13_ENST00000466195.1_3'UTR	NM_014399.3	NP_055214.1	O95857	TSN13_HUMAN	tetraspanin 13	131						integral to plasma membrane|membrane fraction				autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)|skin(1)|stomach(1)	7	Lung NSC(10;0.0494)|all_lung(11;0.109)			UCEC - Uterine corpus endometrioid carcinoma (126;0.188)		GCTGTGGGTTCCGAAGTGTTA	0.368000													13	71					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38798333	38798333	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38798333C>T	ENST00000449082.2	-	9	1121	c.1122G>A	c.(1120-1122)atG>atA	p.M374I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	374					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAAAAAAGATCATATAGATTT	0.473000													36	89					0	0	1	0	0
ERMARD	55780	broad.mit.edu	37	6	170154030	170154030	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:170154030T>A	ENST00000366773.3	+	2	110	c.77T>A	c.(76-78)tTt>tAt	p.F26Y	C6orf70_ENST00000392095.4_Intron|C6orf70_ENST00000366772.2_Missense_Mutation_p.F26Y|C6orf70_ENST00000418781.3_Missense_Mutation_p.F26Y|C6orf70_ENST00000588451.1_5'UTR	NM_001278532.1|NM_018341.1	NP_001265461.1|NP_060811.1	Q5T6L9	CF070_HUMAN		26						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		AATCTTGGGTTTCAACTCAGA	0.353000													10	20					0	0	1	0	0
MS4A3	932	broad.mit.edu	37	11	59829943	59829943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59829943C>T	ENST00000278865.3	+	3	232	c.159C>T	c.(157-159)gcC>gcT	p.A53A	MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000358152.2_Intron|MS4A3_ENST00000534744.1_Intron	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	53						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				TCTTTCAGGCCATCCAGATCC	0.433000													36	88					0	0	1	0	0
WDR93	56964	broad.mit.edu	37	15	90286605	90286605	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90286605G>C	ENST00000268130.7	+	17	2145	c.2044G>C	c.(2044-2046)Gag>Cag	p.E682Q	WDR93_ENST00000560294.1_Missense_Mutation_p.E654Q|WDR93_ENST00000444934.2_Missense_Mutation_p.E399Q	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	682					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			GCTCCAGAGAGAGAACTTCAA	0.577000													15	81					0	0	1	0	0
RP3-400B16.4	0	broad.mit.edu	37	6	4135832	4135832	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:4135832G>A	ENST00000527831.1	+	0	123																											GCTCGGGGGTGGGGCCGGGTC	0.751000													5	15					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072087	9072087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9072087G>A	ENST00000397910.4	-	3	15562	c.15359C>T	c.(15358-15360)tCt>tTt	p.S5120F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5122	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGTTTATAGAAGGAAAAAT	0.443000													28	69					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72952047	72952047	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72952047G>A	ENST00000425042.2	-	13	1553	c.1476C>T	c.(1474-1476)tcC>tcT	p.S492S		NM_030630.2	NP_085133.1			HID1 domain containing																		TGAGGTAGGGGGACACTGTAA	0.617000													7	102					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356729	42356729	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:42356729G>A	ENST00000554171.1	+	5	3333	c.901G>A	c.(901-903)Gga>Aga	p.G301R	LRFN5_ENST00000298119.4_Missense_Mutation_p.G301R|LRFN5_ENST00000554120.1_Missense_Mutation_p.G301R			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	301	Ig-like.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AGTCCTGGAGGGACAAAGGGC	0.468000										HNSCC(30;0.082)			41	97					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151911	158151911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158151911G>A	ENST00000368171.3	+	4	917	c.418G>A	c.(418-420)Gat>Aat	p.D140N		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	140					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TCAAGGAAAAGATATCCTGAG	0.522000													15	278					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32712801	32712801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:32712801C>T	ENST00000421745.2	+	41	8035	c.7901C>T	c.(7900-7902)tCa>tTa	p.S2634L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2634					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					ATACAGTTATCATCTGTCCCA	0.368000													44	88					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7374329	7374329	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7374329C>T	ENST00000502583.1	-	5	1287	c.723G>A	c.(721-723)ggG>ggA	p.G241G	CAGE1_ENST00000338150.4_Silent_p.G241G|CAGE1_ENST00000512086.1_Silent_p.G241G|CAGE1_ENST00000509324.1_5'UTR|CAGE1_ENST00000296742.7_Silent_p.G105G|CAGE1_ENST00000379918.4_Silent_p.G241G	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	241										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					CAGGAATCTCCCCATAATTCT	0.398000													33	125					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121356074	121356074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121356074C>T	ENST00000314583.3	-	7	575	c.484G>A	c.(484-486)Ggg>Agg	p.G162R	HCLS1_ENST00000473883.1_5'UTR|HCLS1_ENST00000428394.2_Intron	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	162					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		TTCTCCACCCCGTACCGGCCA	0.557000													32	100					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15296162	15296162	+	Silent	SNP	G	G	A	rs140040122	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15296162G>A	ENST00000263388.2	-	14	2277	c.2202C>T	c.(2200-2202)gcC>gcT	p.A734A		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	734	EGF-like 19.				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.A734A(1)		breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AGGCGTCTCGGGCCAGGCTCT	0.682000													8	20					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183777626	183777626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183777626C>T	ENST00000318351.1	+	8	970	c.936C>T	c.(934-936)ttC>ttT	p.F312F		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	312						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GTGTCTACTTCGCCCTGTGCC	0.517000													9	114					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32955366	32955366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32955366G>A	ENST00000340811.4	-	10	2246	c.2138C>T	c.(2137-2139)tCc>tTc	p.S713F	PKP2_ENST00000070846.6_Missense_Mutation_p.S757F	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	757					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AAGATTCCGGGACAGATTCCT	0.443000													80	173					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074935	106074935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106074935G>A	ENST00000278071.2	-	3	1327	c.875C>T	c.(874-876)tCc>tTc	p.S292F	ITPRIP_ENST00000358187.2_Missense_Mutation_p.S292F|ITPRIP_ENST00000337478.1_Missense_Mutation_p.S292F	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	292						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						CAGGTACAGGGAATCTGTGGC	0.597000													17	48					0	0	1	0	0
ZNF701	55762	broad.mit.edu	37	19	53086249	53086249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53086249C>T	ENST00000540331.1	+	5	1360	c.1135C>T	c.(1135-1137)Ctt>Ttt	p.L379F	ZNF701_ENST00000301093.2_Missense_Mutation_p.L379F|CTD-3099C6.7_ENST00000599222.1_RNA|ZNF701_ENST00000391785.3_Missense_Mutation_p.L313F	NM_001172655.1	NP_001166126.1	Q9NV72	ZN701_HUMAN	zinc finger protein 701	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(6)	14				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		ACAATCAAACCTTGCACGTCA	0.388000													36	92					0	0	1	0	0
ZNF14	7561	broad.mit.edu	37	19	19822199	19822199	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19822199G>A	ENST00000344099.3	-	4	2029	c.1891C>T	c.(1891-1893)Cga>Tga	p.R631*		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				TCATGCAGTCGAAAGTGACTG	0.393000													14	127					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50600952	50600952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:50600952G>A	ENST00000216373.5	-	19	3238	c.2964C>T	c.(2962-2964)ttC>ttT	p.F988F	SOS2_ENST00000543680.1_Silent_p.F955F	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	988	Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					GGTTTTCAAAGAATCTCTGGA	0.289000													68	173					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383934	108383934	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108383934T>A	ENST00000265843.4	-	6	2410	c.2300A>T	c.(2299-2301)aAa>aTa	p.K767I	EXPH5_ENST00000428840.1_Missense_Mutation_p.K691I|EXPH5_ENST00000443411.1_Missense_Mutation_p.K579I|EXPH5_ENST00000525344.1_Missense_Mutation_p.K760I	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	767					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GGGTGACTTTTTTGAACTTAT	0.378000													64	144					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65517349	65517349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:65517349C>T	ENST00000310193.3	-	5	1296	c.1123G>A	c.(1123-1125)Gat>Aat	p.D375N	CYP7B1_ENST00000523954.1_5'UTR	NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	375					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AGAGTCAAATCCTCCTCAACA	0.428000													18	51					0	0	1	0	0
AIFM3	150209	broad.mit.edu	37	22	21328398	21328398	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21328398C>T	ENST00000399167.2	+	5	642	c.402C>T	c.(400-402)tgC>tgT	p.C134C	AIFM3_ENST00000335375.5_Silent_p.C122C|AIFM3_ENST00000440238.2_Silent_p.C134C|AIFM3_ENST00000333607.6_Silent_p.C134C|AIFM3_ENST00000405089.1_Silent_p.C140C|AIFM3_ENST00000399163.2_Silent_p.C134C	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			ACGGCGCCTGCTTCAACATCA	0.662000													10	21					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814637	242814637	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242814637C>T	ENST00000343216.3	+	2	958	c.930C>T	c.(928-930)tcC>tcT	p.S310S		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	310						integral to membrane											GCCCCATCTCCCTCAACAATG	0.662000													25	61					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76919504	76919504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76919504C>T	ENST00000409709.3	+	43	6158	c.5886C>T	c.(5884-5886)ttC>ttT	p.F1962F	MYO7A_ENST00000409619.2_Silent_p.F1913F|MYO7A_ENST00000605744.1_3'UTR|MYO7A_ENST00000458637.2_Silent_p.F1924F	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1962	FERM 2.		Missing (in USH1B).		actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ATGACTTCTTCTTTGACTTTG	0.527000													3	13					0	0	1	0	0
GHDC	84514	broad.mit.edu	37	17	40344693	40344693	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40344693G>T	ENST00000301671.8	-	4	896	c.455C>A	c.(454-456)gCc>gAc	p.A152D	GHDC_ENST00000436923.2_Missense_Mutation_p.A152D|GHDC_ENST00000414034.3_Missense_Mutation_p.A152D|GHDC_ENST00000428494.2_Missense_Mutation_p.A113D|GHDC_ENST00000587427.1_Missense_Mutation_p.A152D|GHDC_ENST00000593209.1_Missense_Mutation_p.A152D			Q8N2G8	GHDC_HUMAN	GH3 domain containing	152						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CGTCACACGGGCAGTGCGTCC	0.637000													20	36					1.37878e-21	1.38754e-21	1	1	0
ABCB4	5244	broad.mit.edu	37	7	87092091	87092091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87092091C>T	ENST00000265723.4	-	4	380	c.269G>A	c.(268-270)gGa>gAa	p.G90E	ABCB4_ENST00000358400.3_Missense_Mutation_p.G90E|ABCB4_ENST00000545634.1_Missense_Mutation_p.G90E|ABCB4_ENST00000359206.3_Missense_Mutation_p.G90E|ABCB4_ENST00000453593.1_Missense_Mutation_p.G90E	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	90	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GGAGAAGTTTCCTGCAGTATC	0.388000													16	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569978	179569978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179569978C>T	ENST00000589042.1	-	103	29751	c.29527G>A	c.(29527-29529)Gga>Aga	p.G9843R	TTN_ENST00000342992.6_Missense_Mutation_p.G8599R|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G9526R|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9526	Ig-like 79.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGTGATTCCATACATGCGG	0.378000													18	60					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35756549	35756549	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:35756549C>T	ENST00000540320.1	+	29	5249	c.4715C>T	c.(4714-4716)tCg>tTg	p.S1572L	NBEA_ENST00000379939.2_Missense_Mutation_p.S1569L|NBEA_ENST00000310336.4_Missense_Mutation_p.S1572L|NBEA_ENST00000400445.3_Missense_Mutation_p.S1572L			Q8NFP9	NBEA_HUMAN	neurobeachin	1572						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TACTTCATTTCGGTTCTGATG	0.373000													29	98					0	0	1	0	0
MT1JP	4498	broad.mit.edu	37	16	56670357	56670357	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56670357C>T	ENST00000564564.1	+	0	683																											GCAGGTGGCTCCTGCACGTGC	0.572000													10	70					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325912	57325912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57325912G>A	ENST00000326441.9	-	10	4261	c.3898C>T	c.(3898-3900)Cac>Tac	p.H1300Y	PEG3_ENST00000423103.2_Missense_Mutation_p.H1300Y|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.H1174Y|PEG3_ENST00000598410.1_Missense_Mutation_p.H1176Y|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1300					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ACAGTTACGTGATCTGCAAGT	0.458000													21	69					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88853988	88853988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88853988G>A	ENST00000537554.1	-	2	4568	c.1006C>T	c.(1006-1008)Cgc>Tgc	p.R336C	CNR1_ENST00000549890.1_Missense_Mutation_p.R336C|CNR1_ENST00000468898.1_Missense_Mutation_p.R303C|CNR1_ENST00000535130.1_Missense_Mutation_p.R336C|CNR1_ENST00000549716.1_Missense_Mutation_p.R275C|CNR1_ENST00000369501.2_Missense_Mutation_p.R336C|CNR1_ENST00000428600.2_Missense_Mutation_p.R336C|CNR1_ENST00000369499.2_Missense_Mutation_p.R336C|CNR1_ENST00000362094.5_3'UTR	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	336					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	ATGTCCATGCGGGCTTGGTCT	0.567000													44	67					0	0	1	0	0
MAN1C1	57134	broad.mit.edu	37	1	26090428	26090428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26090428C>T	ENST00000374332.4	+	7	1441	c.1111C>T	c.(1111-1113)Ctc>Ttc	p.L371F	MAN1C1_ENST00000374329.1_Missense_Mutation_p.L142F|MAN1C1_ENST00000263979.3_Missense_Mutation_p.L191F	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	371					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		CCCCAACTTCCTCAGCCCAGT	0.582000													31	91					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24884069	24884069	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24884069G>A	ENST00000396432.2	-	20	4249	c.3763C>T	c.(3763-3765)Cgt>Tgt	p.R1255C	ARHGAP21_ENST00000320481.6_Missense_Mutation_p.R1042C	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1254	Rho-GAP.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GTTTTCAGACGATCTAGAGGA	0.303000													19	49					0	0	1	0	0
TMEM133	83935	broad.mit.edu	37	11	100863137	100863137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100863137C>T	ENST00000303130.2	+	1	327	c.98C>T	c.(97-99)cCc>cTc	p.P33L		NM_032021.2	NP_114410.1	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	33						integral to membrane				kidney(2)|large_intestine(1)|lung(1)|prostate(1)	5		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		GTTACTTTCCCCTTGACTAAA	0.423000													32	99					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118960710	118960710	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118960710G>A	ENST00000334549.1	+	2	264	c.264G>A	c.(262-264)caG>caA	p.Q88Q		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	88						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		GGCATCTGCAGAAGGTGAAGC	0.517000													66	166					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48772186	48772186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:48772186G>A	ENST00000314191.2	-	47	6246	c.6190C>T	c.(6190-6192)Cgt>Tgt	p.R2064C	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.R2064C	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2065					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CTCCGAAAACGACCAGTGGCA	0.458000								Non-homologous end-joining					54	166					0	0	1	0	0
SPATA31D4	389761	broad.mit.edu	37	9	84549533	84549533	+	RNA	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84549533A>T	ENST00000585776.1	-	0	1039				SPATA31D4_ENST00000341875.4_RNA																							CCTCCCGCAAAGTGACATGTA	0.517000													9	10					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120474738	120474738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:120474738G>A	ENST00000355622.6	+	3	433	c.332G>A	c.(331-333)gGa>gAa	p.G111E	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.G71E	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	111					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						ATATTGACAGGAAACCCCATC	0.433000													18	48					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77376999	77376999	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77376999G>A	ENST00000451710.3	-	26	4825	c.4588C>T	c.(4588-4590)Ctc>Ttc	p.L1530F	TRPM6_ENST00000376864.4_Missense_Mutation_p.L1530F|TRPM6_ENST00000449912.2_Missense_Mutation_p.L1525F|TRPM6_ENST00000360774.1_Missense_Mutation_p.L1530F|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.L1525F|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1530					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TATCTGCGGAGAGGATTGATC	0.433000													13	77					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52539771	52539771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52539771G>A	ENST00000321725.6	+	15	1745	c.1669G>A	c.(1669-1671)Ggc>Agc	p.G557S		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	557	FAS1 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTTGCGTGACGGCCGCCTGAT	0.637000													14	48					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166032863	166032863	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166032863G>A	ENST00000360093.3	-	3	533	c.42C>T	c.(40-42)ttC>ttT	p.F14F	SCN3A_ENST00000409101.3_Silent_p.F14F|SCN3A_ENST00000283254.7_Silent_p.F14F	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	14						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.F14F(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TAAAAAGGCGGAAGCTTTCAG	0.428000													24	124					0	0	1	0	0
ISPD	729920	broad.mit.edu	37	7	16298032	16298032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:16298032G>A	ENST00000407010.2	-	8	1101	c.1102C>T	c.(1102-1104)Cct>Tct	p.P368S	AC004741.3_ENST00000438573.1_RNA|ISPD_ENST00000399310.3_Missense_Mutation_p.P318S|AC004741.3_ENST00000457112.1_RNA	NM_001101426.3	NP_001094896.1	A4D126	ISPD_HUMAN	isoprenoid synthase domain containing	368					isoprenoid biosynthetic process		nucleotidyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)	9						ACAACAACAGGATATAAAATG	0.318000										Multiple Myeloma(15;0.18)			6	21					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17487897	17487897	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17487897G>A	ENST00000252590.4	-	1	262	c.201C>T	c.(199-201)gcC>gcT	p.A67A		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	67						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ATAGGCCCTCGGCTCGGCGCT	0.592000													11	38					0	0	1	0	0
MMP27	64066	broad.mit.edu	37	11	102567208	102567208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102567208C>T	ENST00000260229.4	-	6	887	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	266			E -> V (in dbSNP:rs1276286).		collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		TTAGCAGGTTCCTTAGGCAGA	0.418000													27	69					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23522829	23522829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:23522829C>T	ENST00000296682.3	+	8	899	c.717C>T	c.(715-717)gcC>gcT	p.A239A		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	239					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						ACCGTTCAGCCCTCAGTCTGC	0.572000										HNSCC(3;0.000094)			11	42					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3215001	3215001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3215001G>A	ENST00000400569.3	-	2	554	c.221C>T	c.(220-222)tCg>tTg	p.S74L	RP13-270P17.2_ENST00000580139.1_RNA|MYOM1_ENST00000356443.4_Missense_Mutation_p.S74L|MYOM1_ENST00000261606.7_Missense_Mutation_p.S74L			P52179	MYOM1_HUMAN	myomesin 1	74						striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GGCGTGCTGCGAGGCCTGCTG	0.682000													13	28					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31606601	31606601	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31606601C>T	ENST00000170150.3	+	9	1023	c.828C>T	c.(826-828)gcC>gcT	p.A276A		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	276						extracellular region	lipid binding										AGGCCGGTGCCCTCAACCTGG	0.667000													16	61					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28121356	28121356	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28121356C>T	ENST00000330236.6	+	6	1482	c.1298C>T	c.(1297-1299)cCc>cTc	p.P433L	ZKSCAN8_ENST00000457389.2_Missense_Mutation_p.P433L	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		GGAGAGAGACCCTATGAATGT	0.498000													11	123					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21742392	21742392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21742392G>A	ENST00000328843.6	+	38	6297	c.6266G>A	c.(6265-6267)cGa>cAa	p.R2089Q	DNAH11_ENST00000409508.3_Missense_Mutation_p.R2082Q			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2089					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TCTCTGAAACGAGGAGATAAA	0.398000									Kartagener syndrome				9	22					0	0	1	0	0
TEX26	122046	broad.mit.edu	37	13	31531050	31531050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:31531050G>A	ENST00000380473.3	+	4	366	c.353G>A	c.(352-354)gGg>gAg	p.G118E		NM_152325.1	NP_689538.1	Q8N6G2	CM026_HUMAN	testis expressed 26	118																	CAACAAACGGGGACACTAAAG	0.388000													27	85					0	0	1	0	0
IGLV8-61	28774	broad.mit.edu	37	22	22453567	22453567	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22453567C>T	ENST00000390283.2	+	0	359																											CACGGGGGCCCAGGCAGATGA	0.488000													32	103					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481952	140481952	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140481952C>T	ENST00000231130.2	+	1	1719	c.1719C>T	c.(1717-1719)acC>acT	p.T573T		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		573	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCCCTGCACCGAGCTGGTGC	0.701000													26	92					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94847297	94847297	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94847297G>A	ENST00000448921.1	-	5	1400	c.828C>T	c.(826-828)ttC>ttT	p.F276F	SERPINA1_ENST00000393087.4_Silent_p.F276F|SERPINA1_ENST00000449399.3_Silent_p.F276F|SERPINA1_ENST00000437397.1_Silent_p.F276F|SERPINA1_ENST00000404814.4_Silent_p.F276F|SERPINA1_ENST00000402629.1_Silent_p.F276F|SERPINA1_ENST00000440909.1_Silent_p.F276F|SERPINA1_ENST00000355814.4_Silent_p.F276F|SERPINA1_ENST00000393088.4_Silent_p.F276F	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	276					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	CAGGCAGGAAGAAGATGGCGG	0.483000													38	69					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13786434	13786434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13786434C>T	ENST00000265104.4	-	52	8778	c.8674G>A	c.(8674-8676)Gaa>Aaa	p.E2892K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2892					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTAGGTGTTTCAGCATCAGCC	0.388000									Kartagener syndrome				22	44					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68424640	68424640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68424640G>A	ENST00000265404.2	+	1	195	c.113G>A	c.(112-114)gGa>gAa	p.G38E	STAP1_ENST00000396225.1_Missense_Mutation_p.G38E	NM_012108.2	NP_036240.1	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	38	PH.				cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						AAGCGGTCAGGATACCGGGTG	0.378000													48	113					0	0	1	0	0
SOHLH2	54937	broad.mit.edu	37	13	36776042	36776042	+	Silent	SNP	C	C	T	rs144247429		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36776042C>T	ENST00000379881.3	-	2	325	c.237G>A	c.(235-237)gaG>gaA	p.E79E	SOHLH2_ENST00000317764.6_Silent_p.E79E|CCDC169-SOHLH2_ENST00000511166.1_Silent_p.E156E|SOHLH2_ENST00000554962.1_Silent_p.E156E	NM_017826.2	NP_060296.2			spermatogenesis and oogenesis specific basic helix-loop-helix 2											autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		CTTCCAGCTCCTCGGCACTTA	0.393000													28	69					0	0	1	0	0
ALDH1A1	216	broad.mit.edu	37	9	75533671	75533671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:75533671C>T	ENST00000297785.3	-	8	869	c.815G>A	c.(814-816)gGa>gAa	p.G272E	ALDH1A1_ENST00000376939.1_Intron	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	272					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	AGGGCTCTTTCCTCCAAGCTC	0.463000													16	91					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156526	22156526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22156526G>A	ENST00000397126.4	-	4	1458	c.1310C>T	c.(1309-1311)tCc>tTc	p.S437F	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAGGTTTGAGGACCAGTTGAA	0.373000													34	80					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90651043	90651043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90651043G>A	ENST00000282146.4	+	2	1364	c.923G>A	c.(922-924)cGa>cAa	p.R308Q		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	308						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				GGACTCTTGCGATCACGCAGG	0.572000													38	77					0	0	1	0	0
FETUB	26998	broad.mit.edu	37	3	186362702	186362702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186362702C>T	ENST00000265029.3	+	4	688	c.587C>T	c.(586-588)tCt>tTt	p.S196F	FETUB_ENST00000539949.1_Missense_Mutation_p.S48F|FETUB_ENST00000382134.3_Missense_Mutation_p.S131F|RP11-134F2.2_ENST00000428501.1_RNA|FETUB_ENST00000382136.3_Missense_Mutation_p.S159F|FETUB_ENST00000450521.1_Missense_Mutation_p.S196F|RP11-134F2.2_ENST00000455926.1_RNA	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	196	Cystatin fetuin-B-type 2.					extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		ACCAGGGCTTCTAGCCAGGTA	0.478000													17	74					0	0	1	0	0
SYT13	57586	broad.mit.edu	37	11	45265663	45265663	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:45265663C>T	ENST00000020926.3	-	6	1332	c.1221G>A	c.(1219-1221)tgG>tgA	p.W407*		NM_001247987.1|NM_020826.2	NP_001234916.1|NP_065877.1	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	407						transport vesicle				breast(1)|large_intestine(3)|lung(16)|ovary(1)|skin(2)	23						GCATCTCCTCCCAGTGGCTGC	0.642000													6	49					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128628034	128628034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128628034G>A	ENST00000429175.2	+	2	307	c.43G>A	c.(43-45)Gac>Aac	p.D15N	FLI1_ENST00000527767.2_3'UTR|FLI1_ENST00000534087.1_5'UTR|FLI1_ENST00000525560.1_5'UTR|FLI1_ENST00000344954.6_5'UTR	NM_002017.3	NP_002008.2	Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	15					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GGTGAGCGACGACCAGTCCCT	0.602000			T	EWSR1	Ewing sarcoma								3	12					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51464871	51464871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51464871C>T	ENST00000298355.3	-	7	2621	c.1500G>A	c.(1498-1500)gtG>gtA	p.V500V	TRIM9_ENST00000338969.5_Silent_p.V496V|TRIM9_ENST00000360392.4_Silent_p.V500V	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	500	Fibronectin type-III.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					GAAGACCATCCACAGTGCACA	0.552000													20	68					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14724560	14724560	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14724560G>A	ENST00000253697.3	+	3	792	c.340G>A	c.(340-342)Gcc>Acc	p.A114T	C3orf20_ENST00000412910.1_5'UTR|C3orf20_ENST00000435614.1_5'UTR	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	114						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						CACTGGGGCAGCCAAGCGCTC	0.627000													3	19					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29840139	29840139	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:29840139G>A	ENST00000375398.2	-	8	663	c.214C>T	c.(214-216)Cga>Tga	p.R72*	SVIL_ENST00000355867.4_Nonsense_Mutation_p.R72*|SVIL_ENST00000375400.3_Nonsense_Mutation_p.R72*			O95425	SVIL_HUMAN	supervillin	72	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TATTTGGATCGAGTTTGCTTT	0.473000													34	65					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64111644	64111644	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64111644C>T	ENST00000356786.5	+	14	1675	c.1631C>T	c.(1630-1632)tCa>tTa	p.S544L	CCDC88B_ENST00000463837.1_3'UTR	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	544					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTCGAGGCATCAGCTGAGTGT	0.632000													42	101					0	0	1	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74641768	74641768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:74641768C>T	ENST00000541184.1	-	8	1244	c.767G>A	c.(766-768)gGc>gAc	p.G256D	ZDHHC15_ENST00000373361.3_3'UTR|ZDHHC15_ENST00000373367.3_Missense_Mutation_p.G265D	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	265						integral to membrane	zinc ion binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						CTTGATGAAGCCAAGGTTGAA	0.433000													21	28					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22191364	22191364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22191364G>A	ENST00000374695.3	-	36	4677	c.4598C>T	c.(4597-4599)cCg>cTg	p.P1533L		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	1533	Laminin EGF-like 9; second part.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GTAGCCTGGCGGGCAGCGGCA	0.687000													4	22					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6711049	6711049	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6711049G>A	ENST00000245907.6	-	12	1520	c.1428C>T	c.(1426-1428)ctC>ctT	p.L476L		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	476					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CCATTCGCAGGAGGAAGTTGA	0.597000													41	187					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4870120	4870120	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4870120G>A	ENST00000322101.2	-	1	394	c.319C>T	c.(319-321)Cta>Tta	p.L107L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACCATCTGTAGAAGGCAGGCT	0.542000													21	95					0	0	1	0	0
PSORS1C2	170680	broad.mit.edu	37	6	31105856	31105856	+	Missense_Mutation	SNP	G	G	A	rs144826968	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31105856G>A	ENST00000259845.4	-	2	606	c.283C>T	c.(283-285)Ccc>Tcc	p.P95S	PSORS1C1_ENST00000259881.9_Intron|PSORS1C1_ENST00000547221.1_Intron	NM_014069.2	NP_054788.2	Q9UIG4	PS1C2_HUMAN	psoriasis susceptibility 1 candidate 2	95						extracellular region				NS(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						TCAGGCCGGGGAGGTTGAGGA	0.657000													31	50					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181689418	181689418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181689418C>T	ENST00000526775.1	+	14	1993	c.1828C>T	c.(1828-1830)Ctc>Ttc	p.L610F	CACNA1E_ENST00000367567.4_Missense_Mutation_p.L217F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.L561F|CACNA1E_ENST00000367570.1_Missense_Mutation_p.L610F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.L610F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.L610F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.L561F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	610					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GCTTTTCCTCCTCTTCCTCTT	0.463000													13	28					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7621969	7621969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7621969G>A	ENST00000256861.6	-	9	1245	c.1167C>T	c.(1165-1167)gcC>gcT	p.A389A	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Silent_p.A389A|ITIH5_ENST00000298441.6_Silent_p.A175A|ITIH5_ENST00000446830.2_Silent_p.A171A|ITIH5_ENST00000397145.2_Silent_p.A389A	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	389	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TGCCACTGTGGGCCACGTACT	0.602000													8	30					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33785177	33785177	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:33785177C>T	ENST00000261326.5	+	6	1177	c.1156C>T	c.(1156-1158)Cag>Tag	p.Q386*		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	386					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	CCCTGAGGTTCAGGGCCCAAT	0.498000													55	84					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81134721	81134721	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81134721G>A	ENST00000534142.1	-	0	1774				PKD1L2_ENST00000533478.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GCGTGTGGACGAACAGCTTAG	0.577000													5	57					0	0	1	0	0
BEND5	79656	broad.mit.edu	37	1	49202013	49202013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:49202013C>T	ENST00000371833.3	-	5	1092	c.1006G>A	c.(1006-1008)Gat>Aat	p.D336N	AGBL4_ENST00000371838.1_Intron|AGBL4_ENST00000371839.1_Intron|BEND5_ENST00000476096.1_Intron	NM_024603.2	NP_078879.2	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	336	BEN.									large_intestine(5)|lung(2)|skin(1)	8						TTCAGAACATCTGTTCCCCAA	0.468000													41	133					0	0	1	0	0
OR7G3	390883	broad.mit.edu	37	19	9237432	9237432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9237432G>A	ENST00000305444.2	-	1	194	c.195C>T	c.(193-195)atC>atT	p.I65I		NM_001001958.1	NP_001001958.1	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G, member 3	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						CCAAGGACAGGATAGAGAGGA	0.547000													48	95					0	0	1	0	0
ANKRD20A5P	440482	broad.mit.edu	37	18	14184125	14184125	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14184125C>T	ENST00000581935.1	+	0	814																				lung(3)	3						AACTTTCTTTCCAAAATATTT	0.333000													25	104					0	0	1	0	0
VSIG4	11326	broad.mit.edu	37	X	65252517	65252517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:65252517G>A	ENST00000455586.2	-	3	613	c.487C>T	c.(487-489)Ctt>Ttt	p.L163F	VSIG4_ENST00000374737.4_Missense_Mutation_p.L163F|VSIG4_ENST00000412866.2_Intron	NM_001184830.1	NP_001171759.1	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	163	Ig-like 2.				complement activation, alternative pathway	integral to membrane	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TGGCATTGAAGGCTAATCCTC	0.483000													8	33					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121410779	121410779	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121410779G>A	ENST00000393667.3	-	14	7542	c.7432C>T	c.(7432-7434)Cga>Tga	p.R2478*	GOLGB1_ENST00000340645.5_Nonsense_Mutation_p.R2473*	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2473					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		ATGCGGTCTCGATCATTTTGG	0.413000													23	204					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215333	140215333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140215333C>T	ENST00000525929.1	+	1	1365	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Silent_p.F455F|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018910.2	NP_061733.1												p.F455L(2)		NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGGCGTTCGCGCAGCCCG	0.677000													33	88					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343311	248343311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248343311C>T	ENST00000359682.2	+	1	24	c.24C>T	c.(22-24)ttC>ttT	p.F8F		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATCAGACCTTCAACTCCGACT	0.423000													51	254					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444290	20444290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20444290C>T	ENST00000305051.5	+	1	688	c.613C>T	c.(613-615)Ctt>Ttt	p.L205F		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTCTGTGACCTTCCTCTAGT	0.418000													85	191					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24832666	24832666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24832666G>A	ENST00000376451.2	+	14	3776	c.3516G>A	c.(3514-3516)ggG>ggA	p.G1172G	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000376454.3_Silent_p.G1489G			Q5T5P2	SKT_HUMAN	KIAA1217	1489					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						aggaaaatggggaTTCTGTAG	0.433000													12	32					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141457967	141457967	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141457967A>T	ENST00000389484.3	-	41	7622	c.6651T>A	c.(6649-6651)aaT>aaA	p.N2217K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2217					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATAACGTGGATTCTCATATG	0.338000										TSP Lung(27;0.18)			19	131					0	0	1	0	0
SLC18A2	6571	broad.mit.edu	37	10	119014811	119014811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:119014811C>T	ENST00000298472.5	+	7	867	c.724C>T	c.(724-726)Ctc>Ttc	p.L242F	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	242					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	CGGGAGTGTGCTCTATGAGTT	0.602000													12	45					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61654077	61654077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:61654077C>T	ENST00000381103.2	+	10	1248	c.763C>T	c.(763-765)Cgt>Tgt	p.R255C	KIF2A_ENST00000407818.3_Missense_Mutation_p.R275C|KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000401507.3_Missense_Mutation_p.R275C|KIF2A_ENST00000506857.1_Missense_Mutation_p.R229C	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	275	Kinesin-motor.				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding	p.R275C(1)|p.R248C(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		CCAAACATTTCGTTTTGATTA	0.323000													8	42					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7122765	7122765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7122765G>A	ENST00000341500.5	-	18	3392	c.3353C>T	c.(3352-3354)cCc>cTc	p.P1118L	INSR_ENST00000302850.5_Missense_Mutation_p.P1130L	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1130	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAGGGTAGGGGGAGGGCGGCC	0.582000													23	48					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27212761	27212761	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27212761C>T	ENST00000380036.4	+	17	3185	c.2743C>T	c.(2743-2745)Cgc>Tgc	p.R915C	TEK_ENST00000519097.1_Missense_Mutation_p.R767C|TEK_ENST00000406359.4_Missense_Mutation_p.R872C	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	915	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GGACTTCCTTCGCAAGAGCCG	0.582000													7	39					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123524485	123524485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123524485G>A	ENST00000392770.2	-	1	827	c.25C>T	c.(25-27)Ccc>Tcc	p.P9S	SCN3B_ENST00000530277.1_Missense_Mutation_p.P9S|SCN3B_ENST00000299333.3_Missense_Mutation_p.P9S	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	9					axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		GAAGCCAGGGGAAACAATCTA	0.502000													51	207					0	0	1	0	0
RHOU	58480	broad.mit.edu	37	1	228879409	228879409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228879409G>A	ENST00000366691.3	+	3	1365	c.699G>A	c.(697-699)aaG>aaA	p.K233K		NM_021205.5	NP_067028.1	Q7L0Q8	RHOU_HUMAN	ras homolog family member U	233					regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	13	Breast(184;0.162)	Prostate(94;0.183)				AACAGCCAAAGAAGTCTAAAA	0.458000													31	88					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686993	68686993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:68686993G>A	ENST00000361320.4	+	2	897	c.319G>A	c.(319-321)Gga>Aga	p.G107R	CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	107						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TGCTTTTAATGGAATACGCAG	0.358000													37	153					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50497861	50497861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50497861G>A	ENST00000301149.3	+	1	260	c.28G>A	c.(28-30)Ggc>Agc	p.G10S	GPD1_ENST00000548814.1_Missense_Mutation_p.G10S|GPD1_ENST00000547190.1_3'UTR	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	10					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	CTGCATTGTAGGCTCCGGGAA	0.587000													26	95					0	0	1	0	0
SSX5	6758	broad.mit.edu	37	X	48049607	48049607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48049607C>T	ENST00000311798.1	-	7	603	c.551G>A	c.(550-552)gGa>gAa	p.G184E	SSX5_ENST00000347757.1_Missense_Mutation_p.G143E|SSX5_ENST00000376923.1_Missense_Mutation_p.G143E	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	143				Q -> P (in Ref. 1; AAC05821).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						ATTTAGTTTTCCTGAGGGGCG	0.483000													64	42					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157737198	157737198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157737198G>A	ENST00000361516.3	-	6	1033	c.985C>T	c.(985-987)Cca>Tca	p.P329S	FCRL2_ENST00000368181.4_Intron|FCRL2_ENST00000469986.1_Missense_Mutation_p.P76S|FCRL2_ENST00000392274.3_Missense_Mutation_p.P329S	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	329	Ig-like C2-type 4.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TACAAGATTGGGGGAGAGCCT	0.597000													37	89					0	0	1	0	0
OTUB2	78990	broad.mit.edu	37	14	94510998	94510998	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94510998G>A	ENST00000203664.5	+	5	579	c.370G>A	c.(370-372)Gac>Aac	p.D124N		NM_023112.3	NP_075601.1	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2	124	OTU.				cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity			kidney(1)|large_intestine(1)|lung(2)|ovary(1)	5		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		GGTGTTCAACGACCAGAGTGC	0.587000													15	45					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35255046	35255046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:35255046G>A	ENST00000360310.1	-	14	2335	c.1768C>T	c.(1768-1770)Cgt>Tgt	p.R590C	BAZ1A_ENST00000382422.2_Missense_Mutation_p.R590C|BAZ1A_ENST00000358716.4_Missense_Mutation_p.R558C	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	590					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TTGCTCAAACGAAGCTCCATA	0.418000													48	93					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130833010	130833010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130833010C>T	ENST00000357462.5	-	15	2128	c.2035G>A	c.(2035-2037)Gat>Aat	p.D679N	POTEF_ENST00000360967.5_3'UTR|POTEF_ENST00000361163.4_3'UTR|POTEF_ENST00000409914.2_Missense_Mutation_p.D679N			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	679						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						CTTTCAATATCCTCCAAATAT	0.388000													7	60					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87718078	87718078	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:87718078G>A	ENST00000436978.1	+	41	6892	c.6412G>A	c.(6412-6414)Gaa>Aaa	p.E2138K	PTPN13_ENST00000316707.6_Missense_Mutation_p.E1942K|PTPN13_ENST00000411767.2_Missense_Mutation_p.E2133K|PTPN13_ENST00000511467.1_Missense_Mutation_p.E2138K|PTPN13_ENST00000427191.2_Missense_Mutation_p.E2114K	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2133						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AGTAAAAAGTGAAAGGTGAGA	0.284000													5	7					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17554814	17554814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17554814C>T	ENST00000005226.7	-	2	91	c.92G>A	c.(91-93)cGa>cAa	p.R31Q	USH1C_ENST00000527720.1_5'UTR|USH1C_ENST00000527020.1_Missense_Mutation_p.R31Q|USH1C_ENST00000318024.4_Missense_Mutation_p.R31Q	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	31					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						GTGGTACATTCGCAGCACATC	0.507000													29	75					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128873892	128873892	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128873892C>T	ENST00000375990.3	+	8	1178	c.775C>T	c.(775-777)Cag>Tag	p.Q259*	UGGT1_ENST00000259253.6_Nonsense_Mutation_p.Q283*			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	283					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TGATGAGGTTCAGGGGTTCCT	0.353000													25	69					0	0	1	0	0
AADAT	51166	broad.mit.edu	37	4	170990371	170990371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:170990371G>A	ENST00000337664.4	-	7	1007	c.731C>T	c.(730-732)cCa>cTa	p.P244L	AADAT_ENST00000515480.1_Missense_Mutation_p.P244L|AADAT_ENST00000509167.1_Missense_Mutation_p.P248L|AADAT_ENST00000353187.2_Missense_Mutation_p.P244L	NM_016228.3	NP_057312.1	Q8N5Z0	AADAT_HUMAN	aminoadipate aminotransferase	244					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|pancreas(1)|stomach(1)	11		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAGAAATGTTGGTACCCTGAA	0.388000													23	36					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55046958	55046958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55046958G>A	ENST00000335056.3	+	4	541	c.503G>A	c.(502-504)gGg>gAg	p.G168E	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		CTTGACCAGGGGATGGAGGCT	0.537000													24	49					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33135598	33135598	+	Missense_Mutation	SNP	C	C	T	rs146082418		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33135598C>T	ENST00000341947.2	-	55	4219	c.3992G>A	c.(3991-3993)cGa>cAa	p.R1331Q	COL11A2_ENST00000357486.1_Missense_Mutation_p.R1310Q|COL11A2_ENST00000361917.1_Missense_Mutation_p.R1224Q|COL11A2_ENST00000374708.4_Missense_Mutation_p.R1245Q|COL11A2_ENST00000395197.1_Missense_Mutation_p.R1271Q|COL11A2_ENST00000374712.1_Missense_Mutation_p.R1250Q|COL11A2_ENST00000374713.1_Missense_Mutation_p.R1284Q|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374714.1_Missense_Mutation_p.R1305Q	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1331	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCCTCCTTGTCGCCCCTCGGA	0.657000													13	30					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60711204	60711204	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60711204G>A	ENST00000227880.3	-	3	1186	c.953C>T	c.(952-954)cCc>cTc	p.P318L		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	318					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						CACCATGACGGGCAAGATCTT	0.612000													6	18					0	0	1	0	0
KRTAP10-3	386682	broad.mit.edu	37	21	45978416	45978416	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45978416G>A	ENST00000391620.1	-	1	227	c.183C>T	c.(181-183)gcC>gcT	p.A61A	TSPEAR_ENST00000323084.4_Intron|TSPEAR_ENST00000397916.1_Intron	NM_198696.2	NP_941969.2	P60369	KR103_HUMAN	keratin associated protein 10-3	61	18 X 5 AA repeats of C-C-X(3).					keratin filament				kidney(1)|lung(4)|prostate(1)|skin(1)	7						TGGGCTCACAGGCCGCCTGGC	0.711000													33	75					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25416232	25416232	+	Missense_Mutation	SNP	C	C	T	rs140457030		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25416232C>T	ENST00000255324.5	+	19	2588	c.2536C>T	c.(2536-2538)Cct>Tct	p.P846S	RNF17_ENST00000381921.1_Missense_Mutation_p.P846S	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	846					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCTTGGTGCTCCTGAAATGAC	0.343000													22	64					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	123953720	123953720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123953720C>T	ENST00000360013.3	+	3	314	c.187C>T	c.(187-189)Cgc>Tgc	p.R63C	KALRN_ENST00000240874.3_Missense_Mutation_p.R63C|KALRN_ENST00000460856.1_Missense_Mutation_p.R63C	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	63	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CTTCCCTGCTCGCAGCAATCA	0.537000													7	12					0	0	1	0	0
LHX3	8022	broad.mit.edu	37	9	139089576	139089576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139089576C>T	ENST00000371746.3	-	6	922	c.804G>A	c.(802-804)ttG>ttA	p.L268L	LHX3_ENST00000371748.5_Silent_p.L263L	NM_014564.3	NP_055379.1	Q9UBR4	LHX3_HUMAN	LIM homeobox 3	263					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	8		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		CCATTTCCGCCAAGGAAGGCT	0.687000													8	23					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167666526	167666526	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167666526G>A	ENST00000367854.3	+	6	996	c.665G>A	c.(664-666)gGa>gAa	p.G222E	RCSD1_ENST00000537350.1_Missense_Mutation_p.G192E	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	222										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					TCCAGTGAGGGAGCAGCGGGA	0.597000													24	40					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700041	136700041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:136700041G>A	ENST00000445907.2	+	3	957	c.429G>A	c.(427-429)atG>atA	p.M143I	CHRM2_ENST00000320658.5_Missense_Mutation_p.M143I|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.M143I|CHRM2_ENST00000397608.3_Missense_Mutation_p.M143I|CHRM2_ENST00000402486.3_Missense_Mutation_p.M143I|CHRM2_ENST00000453373.1_Missense_Mutation_p.M143I|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000593789.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	143					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CAGGTATGATGATTGCAGCTG	0.502000													41	90					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181689353	181689353	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181689353C>T	ENST00000526775.1	+	14	1928	c.1763C>T	c.(1762-1764)tCc>tTc	p.S588F	CACNA1E_ENST00000367567.4_Missense_Mutation_p.S195F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.S539F|CACNA1E_ENST00000367570.1_Missense_Mutation_p.S588F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.S588F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.S588F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.S539F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	588					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TATTGGGCTTCCCTACGGAAT	0.473000													21	45					0	0	1	0	0
FOXN4	121643	broad.mit.edu	37	12	109717725	109717725	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109717725C>T	ENST00000299162.5	-	10	1409	c.1305G>A	c.(1303-1305)tgG>tgA	p.W435*	FOXN4_ENST00000355216.1_Nonsense_Mutation_p.W255*	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	435					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						TCATCTCCTCCCACAGGTTCC	0.557000													10	41					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47236521	47236521	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47236521C>T	ENST00000300404.2	+	6	860	c.801C>T	c.(799-801)ttC>ttT	p.F267F	B4GALNT2_ENST00000504681.1_Silent_p.F181F|B4GALNT2_ENST00000393354.2_Silent_p.F207F	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	267					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			TGTTGAAGTTCATTCTTCAGC	0.532000													71	176					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811474	23811474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23811474C>T	ENST00000314520.3	+	1	1021	c.545C>T	c.(544-546)gCc>gTc	p.A182V	MKRN3_ENST00000564592.1_Intron|MKRN3_ENST00000568252.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	182						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TTCTTTGAAGCCGAGAGAGAC	0.617000													4	56					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51687149	51687149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51687149G>A	ENST00000335449.6	+	5	715	c.659G>A	c.(658-660)gGa>gAa	p.G220E	GLDN_ENST00000396399.2_Missense_Mutation_p.G96E	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	220	Collagen-like 2.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		GGTGACAAAGGAGATGTGTCC	0.582000													10	25					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8591700	8591700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8591700C>T	ENST00000338257.8	-	23	2861	c.2594G>A	c.(2593-2595)aGg>aAg	p.R865K		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	865						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GGGCAGGGGCCTCCGCGTCGC	0.672000													7	19					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156381657	156381657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156381657C>T	ENST00000274532.2	-	2	225	c.169G>A	c.(169-171)Gac>Aac	p.D57N	TIMD4_ENST00000407087.3_Missense_Mutation_p.D57N	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	57	Ig-like V-type.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGCACTGGTCTTTCCCCCAG	0.527000													31	63					0	0	1	0	0
MPZL2	10205	broad.mit.edu	37	11	118133292	118133292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118133292C>T	ENST00000278937.2	-	3	425	c.297G>A	c.(295-297)ggG>ggA	p.G99G	MPZL2_ENST00000438295.2_Silent_p.G99G	NM_005797.3	NP_005788.1	O60487	MPZL2_HUMAN	myelin protein zero-like 2	99	Ig-like V-type.				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|skin(1)	11	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		GCTCAGGATTCCCATCCCAAG	0.517000													5	59					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43109933	43109933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43109933C>T	ENST00000230419.4	+	13	2164	c.1943C>T	c.(1942-1944)tCc>tTc	p.S648F	PTK7_ENST00000481273.1_Missense_Mutation_p.S656F|PTK7_ENST00000345201.2_Missense_Mutation_p.S608F|PTK7_ENST00000349241.2_Missense_Mutation_p.S518F|PTK7_ENST00000352931.2_Intron	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	648	Ig-like C2-type 7.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CAGAATGGCTCCCTGGTGATC	0.627000													28	69					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168093495	168093495	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168093495C>T	ENST00000519560.1	-	36	4955	c.4536G>A	c.(4534-4536)gaG>gaA	p.E1512E	CTC-558O2.2_ENST00000520041.1_RNA|SLIT3_ENST00000332966.8_Silent_p.E1519E	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1512	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTAAGTGTCTCTCCACCTCTT	0.642000													6	18					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124848315	124848315	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124848315G>A	ENST00000356219.3	-	22	2993	c.2838C>T	c.(2836-2838)acC>acT	p.T946T	NCOR2_ENST00000404121.2_Silent_p.T499T|NCOR2_ENST00000405201.1_Silent_p.T946T|NCOR2_ENST00000404621.1_Silent_p.T928T|NCOR2_ENST00000429285.2_Silent_p.T928T|NCOR2_ENST00000397355.1_Silent_p.T929T	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	946					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CGCCAGTCGGGGTGAGGAGGC	0.716000													30	56					0	0	1	0	0
ZCWPW2	152098	broad.mit.edu	37	3	28476733	28476733	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:28476733C>T	ENST00000383768.2	+	4	653	c.465C>T	c.(463-465)ttC>ttT	p.F155F	ZCWPW2_ENST00000421010.1_Silent_p.F155F			Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	155	PWWP.						zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(6)|ovary(2)	17						AGGCAACATTCGTTGGACATT	0.333000													14	84					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22729233	22729233	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:22729233C>T	ENST00000503442.1	+	0	149				GBA3_ENST00000508166.1_RNA|GBA3_ENST00000511446.1_RNA	NM_001128432.2	NP_001121904.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AATTTGAGTCCCAACAAGCAA	0.438000													59	323					0	0	1	0	0
DHCR24	1718	broad.mit.edu	37	1	55319263	55319263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55319263G>A	ENST00000371269.3	-	8	1339	c.1241C>T	c.(1240-1242)cCg>cTg	p.P414L	DHCR24_ENST00000535035.1_Missense_Mutation_p.P373L|DHCR24_ENST00000537443.1_Missense_Mutation_p.P198L	NM_014762.3	NP_055577.1	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase	414					anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			large_intestine(2)|liver(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7						CAGGATGAACGGACACAGCCA	0.577000													10	23					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81181868	81181868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81181868G>A	ENST00000394685.3	+	10	1440	c.1021G>A	c.(1021-1023)Gag>Aag	p.E341K	KIAA1199_ENST00000356249.5_Missense_Mutation_p.E341K|KIAA1199_ENST00000220244.3_Missense_Mutation_p.E341K			Q8WUJ3	K1199_HUMAN	KIAA1199	341										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TAAAGGTGGGGAGAAAATTTC	0.428000													56	79					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133899646	133899646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133899646C>T	ENST00000220616.4	+	9	2069	c.2029C>T	c.(2029-2031)Cct>Tct	p.P677S	TG_ENST00000377869.1_Missense_Mutation_p.P677S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	677	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGGCAGCCAGCCTGCTGGCTC	0.552000													16	52					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189733	124189733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124189733C>T	ENST00000357438.2	-	1	451	c.361G>A	c.(361-363)Gac>Aac	p.D121N		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		ACATAACGGTCATATTCCATG	0.408000													24	51					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49459669	49459669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49459669C>T	ENST00000374201.3	-	2	393	c.91G>A	c.(91-93)Gag>Aag	p.E31K	FRMPD2_ENST00000407470.4_Missense_Mutation_p.E22K|FRMPD2_ENST00000305531.3_Missense_Mutation_p.E29K	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	31	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		CAGATTTCCTCCTCAGACAGA	0.577000													5	73					0	0	1	0	0
TREML1	340205	broad.mit.edu	37	6	41121799	41121799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41121799C>T	ENST00000373127.4	-	2	121	c.73G>A	c.(73-75)Gtg>Atg	p.V25M	TREML1_ENST00000426005.2_Missense_Mutation_p.V25M|TREML1_ENST00000437044.2_Intron	NM_001271807.1	NP_001258736.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	25	Ig-like V-type.				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCCTGCAGCACCTCAGGGAGG	0.612000													11	38					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167023529	167023529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167023529C>T	ENST00000392766.2	-	17	1967	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	ZBBX_ENST00000307529.5_Missense_Mutation_p.E543K|ZBBX_ENST00000392764.1_Missense_Mutation_p.E514K|ZBBX_ENST00000392767.2_Missense_Mutation_p.E543K|ZBBX_ENST00000455345.2_Missense_Mutation_p.E543K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	543						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AATTTCTCCTCAATGGGAGCT	0.353000													24	48					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50661436	50661436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:50661436C>T	ENST00000371824.1	+	5	969	c.712C>T	c.(712-714)Cac>Tac	p.H238Y	ELAVL4_ENST00000448907.2_Missense_Mutation_p.H241Y|ELAVL4_ENST00000371823.4_Missense_Mutation_p.H238Y|ELAVL4_ENST00000371819.1_Missense_Mutation_p.H243Y|ELAVL4_ENST00000371821.1_Missense_Mutation_p.H243Y|ELAVL4_ENST00000371827.1_Missense_Mutation_p.H238Y|ELAVL4_ENST00000357083.4_Missense_Mutation_p.H255Y			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	238					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						AGGTCCACTTCACCACCAGGC	0.597000													29	83					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101092443	101092443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101092443C>T	ENST00000360863.6	-	4	452	c.258G>A	c.(256-258)agG>agA	p.R86R	RGS22_ENST00000523437.1_Silent_p.R86R|RGS22_ENST00000523287.1_5'UTR	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	86				Missing (in Ref. 1; AAH92411).	negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TCTTTCCTTTCCTTACAACAT	0.338000													35	74					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73659854	73659854	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73659854C>T	ENST00000261917.3	-	1	1751	c.758G>A	c.(757-759)tGg>tAg	p.W253*		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	253	Involved in subunit assembly (By similarity).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		GTGGATAATCCAAAATCCGGC	0.607000													21	87					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152768620	152768620	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152768620G>A	ENST00000367255.5	-	29	4243	c.3642C>T	c.(3640-3642)ttC>ttT	p.F1214F	SYNE1_ENST00000341594.5_Silent_p.F1280F|SYNE1_ENST00000367248.3_Silent_p.F1204F|SYNE1_ENST00000423061.1_Silent_p.F1221F|SYNE1_ENST00000448038.1_Silent_p.F1221F|SYNE1_ENST00000265368.4_Silent_p.F1214F|SYNE1_ENST00000413186.2_Silent_p.F1214F|SYNE1_ENST00000367253.4_Silent_p.F1214F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1214					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAAGAGCCTTGAAAGAGCTGG	0.453000										HNSCC(10;0.0054)			21	22					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196749920	196749920	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:196749920G>A	ENST00000296350.5	-	5	665	c.552C>T	c.(550-552)tcC>tcT	p.S184S	MFI2_ENST00000296351.4_Silent_p.S184S	NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	184	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GGCGACAGAGGGACTCAGAGT	0.617000													25	29					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63173904	63173904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:63173904G>A	ENST00000449996.3	+	9	709	c.637G>A	c.(637-639)Gaa>Aaa	p.E213K	RGS9_ENST00000443584.3_Missense_Mutation_p.E213K|RGS9_ENST00000577186.1_3'UTR|RGS9_ENST00000262406.9_Missense_Mutation_p.E213K	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	213					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						CAATCCGAATGAAGTCAAGGT	0.493000													30	67					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38568232	38568232	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38568232A>T	ENST00000399017.2	+	42	8221	c.5474A>T	c.(5473-5475)aAg>aTg	p.K1825M	TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Missense_Mutation_p.K1825M|TTC3_ENST00000355666.1_Missense_Mutation_p.K1825M	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1825					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				GCTGATCGGAAGCAGCCTGTT	0.572000													19	30					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145537316	145537316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145537316G>A	ENST00000394434.2	-	9	980	c.814C>T	c.(814-816)Ctt>Ttt	p.L272F	LARS_ENST00000545646.1_Missense_Mutation_p.L226F|LARS_ENST00000510191.1_Missense_Mutation_p.L218F|LARS_ENST00000274562.9_Missense_Mutation_p.L245F|LARS_ENST00000511505.1_5'UTR	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	272	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TATGGCTCAAGCACCTTCAAT	0.348000													34	64					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27499923	27499923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27499923G>A	ENST00000396271.3	-	9	1150	c.1024C>T	c.(1024-1026)Cgt>Tgt	p.R342C	ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375888.1_Missense_Mutation_p.R351C|ACBD5_ENST00000375901.1_Missense_Mutation_p.R233C|ACBD5_ENST00000375905.4_Missense_Mutation_p.R307C|ACBD5_ENST00000375897.3_Missense_Mutation_p.R165C	NM_145698.3	NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	351					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding	p.R307C(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						ATATCTTCACGAAATCCAGAA	0.418000													67	169					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54792418	54792418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54792418C>T	ENST00000293379.4	-	28	3167	c.2906G>A	c.(2905-2907)cGa>cAa	p.R969Q	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	969					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding	p.R969Q(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						AGGCAGGATTCGGTAGGGCAT	0.577000													12	32					0	0	1	0	0
BTN1A1	696	broad.mit.edu	37	6	26502051	26502051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26502051G>A	ENST00000244513.6	+	2	379	c.313G>A	c.(313-315)Ggg>Agg	p.G105R		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	105	Ig-like V-type 1.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						CATCGCCAAGGGGCGCGTGGC	0.667000													8	50					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75993946	75993946	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75993946G>A	ENST00000274364.6	+	33	4638	c.4341G>A	c.(4339-4341)aaG>aaA	p.K1447K	IQGAP2_ENST00000396234.3_Silent_p.K943K|IQGAP2_ENST00000502745.1_Silent_p.K943K|CTD-2384B11.2_ENST00000507514.1_RNA|IQGAP2_ENST00000379730.3_Silent_p.K949K	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1447					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CCTACATAAAGACTTGTTTAG	0.328000													15	37					0	0	1	0	0
TAP2	6891	broad.mit.edu	37	6	32798475	32798475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32798475G>A	ENST00000374897.2	-	8	1512	c.1381C>T	c.(1381-1383)Ccc>Tcc	p.P461S	TAP2_ENST00000452392.2_Missense_Mutation_p.P461S|TAP2_ENST00000374899.4_Missense_Mutation_p.P461S	NM_000544.3	NP_000535.3	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	461					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										AGAGTGGTGGGGGCAAGCGTG	0.537000													18	27					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133389993	133389993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:133389993G>A	ENST00000204726.3	-	4	977	c.419C>T	c.(418-420)tCt>tTt	p.S140F	GOLGA3_ENST00000537452.1_Missense_Mutation_p.S140F|GOLGA3_ENST00000450791.2_Missense_Mutation_p.S140F|GOLGA3_ENST00000456883.2_Missense_Mutation_p.S140F|GOLGA3_ENST00000545875.1_Missense_Mutation_p.S140F	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	140	Interaction with GOPC.	Cleavage; by caspase-3.			intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GGGCAGGGGAGAATCTGTAGA	0.512000													15	19					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23406208	23406208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23406208C>T	ENST00000216036.4	-	5	721	c.525G>A	c.(523-525)ctG>ctA	p.L175L		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	175							binding			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		GGCAGAGGACCAGTGTGTCCA	0.577000													10	49					0	0	1	0	0
LMX1B	4010	broad.mit.edu	37	9	129458122	129458122	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:129458122C>T	ENST00000355497.5	+	7	931	c.924C>T	c.(922-924)gtC>gtT	p.V308V	LMX1B_ENST00000425646.2_Silent_p.V274V|LMX1B_ENST00000526117.1_Silent_p.V297V|LMX1B_ENST00000373474.4_Silent_p.V297V|LMX1B_ENST00000561065.1_Silent_p.V285V	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	274					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						CCCCAGAGGTCCTGTCCAGCC	0.667000									Nail-Patella Syndrome				10	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179642167	179642167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179642167G>A	ENST00000589042.1	-	26	4849	c.4625C>T	c.(4624-4626)tCa>tTa	p.S1542L	TTN_ENST00000342992.6_Missense_Mutation_p.S1542L|TTN_ENST00000360870.5_Missense_Mutation_p.S1542L|TTN_ENST00000460472.2_Missense_Mutation_p.S1496L|TTN_ENST00000342175.6_Missense_Mutation_p.S1496L|TTN_ENST00000359218.5_Missense_Mutation_p.S1496L|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S1542L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1542	Ig-like 6.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAAATCACTGAAATTGAAGA	0.383000													8	32					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33466940	33466940	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33466940G>A	ENST00000379471.2	-	15	2007	c.1920C>T	c.(1918-1920)ccC>ccT	p.P640P	NOL6_ENST00000455041.2_Silent_p.P588P|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	640					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GTGCATCCAGGGGGCCCCCCA	0.517000											OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	376					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155724215	155724215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155724215G>A	ENST00000437809.1	-	28	5704	c.5582C>T	c.(5581-5583)tCc>tTc	p.S1861F	GON4L_ENST00000368331.1_Missense_Mutation_p.S1861F|GON4L_ENST00000271883.5_Missense_Mutation_p.S1861F			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1861					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTTCAGCTTGGAATCTGGACC	0.542000													21	178					0	0	1	0	0
LOC442028	442028	broad.mit.edu	37	2	95558357	95558357	+	RNA	SNP	G	G	A	rs76554397		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95558357G>A	ENST00000568768.1	-	0	476																											ACCACCAACCGGTGAAATCCA	0.428000													12	23					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3712680	3712680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3712680G>A	ENST00000324932.7	-	28	4771	c.4351C>T	c.(4351-4353)Cct>Tct	p.P1451S	NUP98_ENST00000355260.3_Missense_Mutation_p.P1451S|NUP98_ENST00000359171.4_Missense_Mutation_p.P1451S	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1468					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity	p.P1451S(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGATACGAAGGAAGTGGGGAG	0.428000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								11	57					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179575439	179575439	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179575439C>T	ENST00000589042.1	-	98	28609	c.28385G>A	c.(28384-28386)gGa>gAa	p.G9462E	TTN_ENST00000342992.6_Missense_Mutation_p.G8218E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G9145E|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9145	Ig-like 77.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGAATCTCCTTTGTCTAC	0.438000													57	78					0	0	1	0	0
GGTLC1	92086	broad.mit.edu	37	20	23966723	23966723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23966723G>A	ENST00000335694.4	-	3	498	c.294C>T	c.(292-294)ttC>ttT	p.F98F	GGTLC1_ENST00000286890.4_Silent_p.F98F|GGTLC1_ENST00000278765.4_Silent_p.F98F	NM_178311.2	NP_842563.1	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	98							gamma-glutamyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	15						CTGGCTGGATGAAATTGGCAG	0.612000													32	116					0	0	1	0	0
FAM149A	25854	broad.mit.edu	37	4	187093119	187093119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187093119G>A	ENST00000356371.5	+	14	2300	c.2300G>A	c.(2299-2301)aGg>aAg	p.R767K	FAM149A_ENST00000514153.1_Missense_Mutation_p.R476K|FAM149A_ENST00000503432.1_Missense_Mutation_p.R476K|FAM149A_ENST00000502970.1_Missense_Mutation_p.R476K|FAM149A_ENST00000389354.5_Missense_Mutation_p.R476K|FAM149A_ENST00000227065.4_Missense_Mutation_p.R476K			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	767										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		ACTTTCAAGAGGAGATTCCAA	0.418000													13	96					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974138	49974138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49974138C>T	ENST00000555099.1	+	1	196	c.164C>T	c.(163-165)tCc>tTc	p.S55F		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						TCACTGAGATCCCCCATGTAC	0.428000													104	152					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685759	248685759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248685759G>A	ENST00000343414.4	+	1	844	c.812G>A	c.(811-813)gGa>gAa	p.G271E		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAAAACCAGGGAAAGTTTGTT	0.438000													28	89					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241815373	241815373	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241815373C>T	ENST00000307503.3	+	8	1185	c.798C>T	c.(796-798)gtC>gtT	p.V266V		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	266					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CAATCCCCGTCATCAGCCTGT	0.617000													4	43					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80044225	80044225	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80044225G>A	ENST00000306749.2	-	22	3855	c.3637C>T	c.(3637-3639)Cct>Tct	p.P1213S		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1213					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CTGAGCAGAGGGTCCTCTGGC	0.667000													7	19					0	0	1	0	0
TTC27	55622	broad.mit.edu	37	2	32891781	32891781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:32891781C>T	ENST00000317907.4	+	7	1116	c.885C>T	c.(883-885)gtC>gtT	p.V295V		NM_001193509.1|NM_017735.4	NP_001180438.1|NP_060205.3	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	295							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						AAGGGGATGTCCTTTCAAATT	0.373000													38	86					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57931719	57931719	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57931719G>A	ENST00000574161.1	+	10	1214	c.1095G>A	c.(1093-1095)aaG>aaA	p.K365K	GCOM1_ENST00000396180.1_Silent_p.K334K|GCOM1_ENST00000380560.2_Silent_p.K296K|GCOM1_ENST00000380561.2_Silent_p.K334K|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000380569.2_Silent_p.K365K|GCOM1_ENST00000572390.1_Silent_p.K365K|MYZAP_ENST00000267853.5_Silent_p.K365K|GCOM1_ENST00000587652.1_Silent_p.K365K|MYZAP_ENST00000380565.4_Silent_p.K365K|GCOM1_ENST00000380568.3_Silent_p.K365K	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		365					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GCCAGCAGAAGAAAGTCAAGC	0.522000													10	34					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64517912	64517912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64517912C>T	ENST00000164139.3	-	17	2511	c.2113G>A	c.(2113-2115)Gga>Aga	p.G705R	PYGM_ENST00000377432.3_Missense_Mutation_p.G617R	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	705					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	TTTTCCTCTCCCGCCTCTTCT	0.557000													16	231					0	0	1	0	0
C1orf115	79762	broad.mit.edu	37	1	220870013	220870013	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:220870013C>T	ENST00000294889.5	+	2	927	c.369C>T	c.(367-369)ttC>ttT	p.F123F		NM_024709.4	NP_078985.3	Q9H7X2	CA115_HUMAN	chromosome 1 open reading frame 115	123						integral to membrane		p.F123F(1)		large_intestine(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0273)		TGCAAGGCTTCGCTGCAGCCT	0.557000													46	116					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23517687	23517687	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23517687G>A	ENST00000397359.3	-	13	2221	c.1960_splice	c.e13-1	p.A654_splice	CDH24_ENST00000487137.2_Splice_Site_p.A616_splice|CDH24_ENST00000554034.1_Splice_Site_p.A616_splice|CDH24_ENST00000485922.1_5'UTR|CDH24_ENST00000267383.5_Splice_Site_p.A654_splice	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	654					adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GCACCACCAGGGCTGCGCGAG	0.647000													29	91					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43909390	43909390	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43909390C>T	ENST00000562955.1	+	61	8577	c.8577C>T	c.(8575-8577)ttC>ttT	p.F2859F	SZT2_ENST00000372442.1_Silent_p.F2017F	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2916						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GCTTGGCTTTCCTGCAGCAAT	0.622000													57	160					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166911222	166911222	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166911222C>T	ENST00000423058.2	-	4	545	c.528G>A	c.(526-528)agG>agA	p.R176R	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Silent_p.R176R|SCN1A_ENST00000303395.4_Silent_p.R176R|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.R176R	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	176						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AACAGAATCCCCTTGCAATAA	0.323000													4	44					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100677281	100677281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100677281G>A	ENST00000306151.4	+	3	2648	c.2584G>A	c.(2584-2586)Gaa>Aaa	p.E862K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	862	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTTATAGTGAAGGAAGAAC	0.488000													181	478					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494140	55494140	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55494140C>T	ENST00000543010.1	+	6	1217	c.1074C>T	c.(1072-1074)ggC>ggT	p.G358G	NLRP2_ENST00000263437.6_Silent_p.G355G|NLRP2_ENST00000537859.1_Silent_p.G336G|NLRP2_ENST00000391721.4_Silent_p.G334G|NLRP2_ENST00000448584.2_Silent_p.G358G|NLRP2_ENST00000339757.7_Silent_p.G336G|NLRP2_ENST00000538819.1_Silent_p.G334G|NLRP2_ENST00000427260.2_Silent_p.G335G	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	358	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGGTGGAGGGCTTCCTGGAGG	0.622000													4	35					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74276776	74276776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74276776C>T	ENST00000262765.5	-	10	4101	c.3922G>A	c.(3922-3924)Gaa>Aaa	p.E1308K		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1308							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						TTGGCCTTTTCCTTTTCGAGC	0.592000													28	93					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101815074	101815074	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101815074G>A	ENST00000263468.8	+	3	597	c.327G>A	c.(325-327)caG>caA	p.Q109Q		NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	109							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AAAGAAAACAGAAGTTTGAAG	0.358000													24	58					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2040308	2040308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2040308C>T	ENST00000262113.4	+	16	2104	c.1963C>T	c.(1963-1965)Ctc>Ttc	p.L655F	MYOM2_ENST00000523438.1_Missense_Mutation_p.L80F	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	655	Fibronectin type-III 3.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CGGAACCAACCTCTGGGAGCC	0.612000													11	77					0	0	1	0	0
LECT1	11061	broad.mit.edu	37	13	53286957	53286957	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:53286957C>T	ENST00000448904.2	-	5	626	c.516G>A	c.(514-516)tgG>tgA	p.W172*	LECT1_ENST00000377962.3_Nonsense_Mutation_p.W172*	NM_001011705.1|NM_007015.2	NP_001011705.1|NP_008946.1	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1	172	BRICHOS.				cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	15		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		CTACAGCCACCCAGATAAGAG	0.408000													31	78					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42185719	42185719	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:42185719G>A	ENST00000379310.3	-	39	4938	c.4870C>T	c.(4870-4872)Cag>Tag	p.Q1624*		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		GACCTCTGCTGGAATGCTCTC	0.512000													31	109					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31320253	31320253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31320253C>T	ENST00000269197.5	+	11	2885	c.2885C>T	c.(2884-2886)tCa>tTa	p.S962L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	962					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TCAGAGATATCAAAGAGAAAA	0.423000													6	11					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72085567	72085567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:72085567C>T	ENST00000555818.1	+	3	1940	c.1592C>T	c.(1591-1593)tCt>tTt	p.S531F	SIPA1L1_ENST00000381232.3_Missense_Mutation_p.S531F|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.S6F|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.S531F	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	531					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAAAATGGATCTCCGTACAAC	0.403000													28	79					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25283504	25283504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25283504C>T	ENST00000218548.6	+	18	2847	c.2514C>T	c.(2512-2514)atC>atT	p.I838I	ATP12A_ENST00000381946.3_Silent_p.I832I	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	832					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CCCTCTAGATCCCCTCCATTG	0.592000													16	81					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072864	17072864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17072864C>T	ENST00000359963.3	-	1	836	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	193					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCGTCTAGTTCCTTGATAGCC	0.612000													27	72					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52901670	52901670	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52901670C>T	ENST00000261844.7	-	6	1593	c.1441G>A	c.(1441-1443)Gag>Aag	p.E481K	FAM214A_ENST00000546305.2_Missense_Mutation_p.E488K	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	481								p.E481K(1)									TCTTGCCGCTCCTGGAGTAAA	0.428000													12	164					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57970952	57970952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57970952G>A	ENST00000302592.6	-	1	701	c.702C>T	c.(700-702)atC>atT	p.I234I		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				CAGCTCTGATGATGCAGACAT	0.438000													20	60					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164776773	164776773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164776773C>T	ENST00000264382.3	-	12	1438	c.1376G>A	c.(1375-1377)gGa>gAa	p.G459E		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	459	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGGTGTACTTCCATCTGACTC	0.373000										HNSCC(35;0.089)			9	45					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140682678	140682678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140682678G>A	ENST00000239451.4	-	1	934	c.755C>T	c.(754-756)aCc>aTc	p.T252I		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	252					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	ACTTAAGAGGGTACCAATAAA	0.428000													17	48					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20497945	20497945	+	Missense_Mutation	SNP	G	G	A	rs148142047		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20497945G>A	ENST00000573854.1	+	14	1793	c.1679G>A	c.(1678-1680)cGa>cAa	p.R560Q	ACSM2A_ENST00000575690.1_Missense_Mutation_p.R560Q|ACSM2A_ENST00000219054.6_Missense_Mutation_p.R560Q|ACSM2A_ENST00000536134.1_Missense_Mutation_p.R332Q|ACSM2A_ENST00000417235.2_Missense_Mutation_p.R481Q|ACSM2A_ENST00000396104.2_Missense_Mutation_p.R560Q	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	560					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding	p.R560Q(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AAAATTCAACGAGCCAAGCTT	0.473000													56	180					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66433743	66433743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:66433743C>T	ENST00000383703.3	-	16	2688	c.2085G>A	c.(2083-2085)ggG>ggA	p.G695G	SLC25A26_ENST00000536651.1_Intron|LRIG1_ENST00000273261.3_Silent_p.G718G|LRIG1_ENST00000496559.2_5'UTR			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	718	Ig-like C2-type 3.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCGGAGGGTTCCCCGTGGCTT	0.607000													26	82					0	0	1	0	0
NAP1L5	266812	broad.mit.edu	37	4	89618461	89618461	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89618461C>T	ENST00000323061.5	-	1	925	c.445G>A	c.(445-447)Gag>Aag	p.E149K	HERC3_ENST00000402738.1_Intron|HERC3_ENST00000264345.3_Intron|HERC3_ENST00000543130.1_Intron	NM_153757.2	NP_715638.1	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	149	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		tccccctcctcctcgtcatcc	0.637000													34	77					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32789541	32789541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:32789541G>A	ENST00000326958.1	+	1	597	c.34G>A	c.(34-36)Gaa>Aaa	p.E12K	NPR3_ENST00000265074.8_3'UTR																							ACATTTCTCTGAAGAACCATC	0.393000													49	128					0	0	1	0	0
FAN1	22909	broad.mit.edu	37	15	31206141	31206141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:31206141C>T	ENST00000362065.4	+	5	1949	c.1658C>T	c.(1657-1659)tCg>tTg	p.S553L		NM_014967.4	NP_055782.3	Q9Y2M0	FAN1_HUMAN	FANCD2/FANCI-associated nuclease 1	553					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding	p.S553L(1)		autonomic_ganglia(2)|breast(2)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(6)|lung(8)|skin(1)	29						CTACTGTTTTCGTTGACCGAC	0.502000								Direct reversal of damage					14	73					0	0	1	0	0
INMT	11185	broad.mit.edu	37	7	30795320	30795320	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30795320C>T	ENST00000013222.5	+	3	661	c.645C>T	c.(643-645)gcC>gcT	p.A215A	INMT-FAM188B_ENST00000458257.1_Intron|INMT_ENST00000409539.1_Silent_p.A214A|INMT_ENST00000484180.1_3'UTR	NM_001199219.1|NM_006774.4	NP_001186148.1|NP_006765.4	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	215						cytoplasm	amine N-methyltransferase activity			kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|stomach(1)	23						CCTGCGTGGCCCTGGAGAAAG	0.587000													10	66					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96025959	96025959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96025959C>T	ENST00000297954.4	+	14	3522	c.3522C>T	c.(3520-3522)tcC>tcT	p.S1174S	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Silent_p.S786S|WNK2_ENST00000349097.3_Silent_p.S786S|WNK2_ENST00000395477.2_Silent_p.S1174S|WNK2_ENST00000356055.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1174					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						ACCGCAGGTCCACGCGTGCGC	0.687000													3	9					0	0	1	0	0
GPATCH1	55094	broad.mit.edu	37	19	33587345	33587345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33587345C>T	ENST00000170564.2	+	7	1159	c.845C>T	c.(844-846)tCa>tTa	p.S282L		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	282						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					TTGGGAATTTCAGGCCAGGTA	0.343000													10	58					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51464813	51464813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51464813C>T	ENST00000298355.3	-	7	2679	c.1558G>A	c.(1558-1560)Gga>Aga	p.G520R	TRIM9_ENST00000338969.5_Missense_Mutation_p.G516R|TRIM9_ENST00000360392.4_Missense_Mutation_p.G520R	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	520	Fibronectin type-III.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					GGGCTGACTCCTGTTTTGTTG	0.537000													10	50					0	0	1	0	0
ITPK1	3705	broad.mit.edu	37	14	93408217	93408217	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93408217G>A	ENST00000267615.6	-	11	1107	c.934C>T	c.(934-936)Ctc>Ttc	p.L312F	ITPK1_ENST00000555495.1_Missense_Mutation_p.L193F|ITPK1_ENST00000354313.3_Intron|ITPK1_ENST00000556603.2_Missense_Mutation_p.L312F			Q13572	ITPK1_HUMAN	inositol-tetrakisphosphate 1-kinase	312	ATP-grasp.				blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)	11		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		TGGTTCAGGAGGTCTGTGAAG	0.657000													6	25					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38770069	38770069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38770069G>A	ENST00000449082.2	-	15	2603	c.2604C>T	c.(2602-2604)atC>atT	p.I868I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	868					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCAAGAAAAGGATGAGGCATA	0.517000													19	46					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58125397	58125397	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58125397C>T	ENST00000257897.3	-	9	1059	c.974G>A	c.(973-975)cGa>cAa	p.R325Q	AGAP2_ENST00000547588.1_Missense_Mutation_p.R661Q	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	661	Interaction with PLCG1 (By similarity).				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding	p.R325Q(1)		breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						ATCCAAGCTTCGTTTCTCGGA	0.532000													6	59					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94983448	94983448	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94983448C>T	ENST00000357742.4	+	17	2129	c.2129C>T	c.(2128-2130)cCc>cTc	p.P710L	MCTP2_ENST00000451018.3_Intron	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	710					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TATATGATCCCCTTGGCATTG	0.413000													47	351					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181341	140181341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140181341G>A	ENST00000522353.2	+	1	559	c.559G>A	c.(559-561)Gag>Aag	p.E187K	PCDHA3_ENST00000532566.2_Missense_Mutation_p.E187K|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGAAATGATGAGGAAATTAA	0.373000													40	57					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1811607	1811607	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1811607G>A	ENST00000539485.1	-	2	362	c.129C>T	c.(127-129)atC>atT	p.I43I	ATP8B3_ENST00000310127.6_Silent_p.I43I|ATP8B3_ENST00000525591.1_5'UTR|ATP8B3_ENST00000526092.1_5'UTR			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	43					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCTCCGCGGATGCCAGCAG	0.667000													9	23					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43872552	43872552	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43872552C>T	ENST00000261488.6	-	12	1953	c.1376G>A	c.(1375-1377)cGa>cAa	p.R459Q	ENOX1_ENST00000412891.1_Missense_Mutation_p.R459Q	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	459					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TTCTTCTGTTCGGAAAAGCTG	0.478000													42	110					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52567414	52567414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52567414C>T	ENST00000313234.5	-	5	898	c.801G>A	c.(799-801)ctG>ctA	p.L267L	KRT80_ENST00000394815.2_Silent_p.L267L	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	267	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		CGGCCTCCTCCAGGCTGCGAG	0.662000													28	77					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71942074	71942074	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71942074C>T	ENST00000298229.2	+	12	1542	c.1338C>T	c.(1336-1338)ttC>ttT	p.F446F	INPPL1_ENST00000538751.1_Silent_p.F204F|INPPL1_ENST00000541756.1_Silent_p.F204F	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	446					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CATCCTGGTTCACATCGAAGG	0.587000													40	155					0	0	1	0	0
C8orf47	203111	broad.mit.edu	37	8	99101746	99101746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:99101746G>A	ENST00000318528.3	+	2	860	c.501G>A	c.(499-501)aaG>aaA	p.K167K	C8orf47_ENST00000545282.1_Intron	NM_173549.2	NP_775820.2	Q6P6B1	CH047_HUMAN	chromosome 8 open reading frame 47	167										kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(2)	13	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			CAGTAGAGAAGGACTCTCTCA	0.517000													4	48					0	0	1	0	0
DCLK2	166614	broad.mit.edu	37	4	151177266	151177266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:151177266C>T	ENST00000296550.7	+	16	2922	c.2168C>T	c.(2167-2169)cCc>cTc	p.P723L	DCLK2_ENST00000506325.1_Missense_Mutation_p.P722L|DCLK2_ENST00000302176.8_Missense_Mutation_p.P740L	NM_001040260.3	NP_001035350.2	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2	723	Pro-rich.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					CCAGTTCCTCCCTCAGTGGAG	0.647000													4	31					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59937222	59937222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59937222G>A	ENST00000259008.2	-	3	407	c.140C>T	c.(139-141)cCc>cTc	p.P47L	BRIP1_ENST00000577598.1_Missense_Mutation_p.P47L	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	47	Helicase ATP-binding.		P -> A (in BC; early onset; loss of ATPase and helicase activities; dbSNP:rs28903098).		DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						ACTTCCTGTGGGACTCTCCAA	0.353000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					18	98					0	0	1	0	0
ZIM3	114026	broad.mit.edu	37	19	57648289	57648289	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57648289T>A	ENST00000269834.1	-	4	578	c.193A>T	c.(193-195)Aag>Tag	p.K65*		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	65	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATGGCTCCTTTCCTTGTTCC	0.527000													38	92					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47882631	47882631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47882631G>A	ENST00000289672.2	-	34	5424	c.5374C>T	c.(5374-5376)Ctg>Ttg	p.L1792L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1792					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGGCCCGGCAGGGAAGCTTCT	0.478000													6	45					0	0	1	0	0
RBM43	375287	broad.mit.edu	37	2	152107524	152107524	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152107524G>A	ENST00000331426.5	-	4	1121	c.970C>T	c.(970-972)Ctg>Ttg	p.L324L		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	324							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		AGGTTAATCAGGACTTCAAGG	0.343000													32	91					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133942568	133942568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133942568C>T	ENST00000361069.4	+	14	2702	c.2569C>T	c.(2569-2571)Cct>Tct	p.P857S	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	857	Laminin EGF-like 8.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CGCCCTGGCCCCTCGACCCGC	0.647000													46	48					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388862	48388862	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48388862G>A	ENST00000224600.4	-	1	2129	c.2016C>T	c.(2014-2016)gcC>gcT	p.A672A		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	672	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CTGTGCGGTAGGCGCCCTGGG	0.667000													13	25					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233275579	233275579	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233275579G>A	ENST00000258229.8	-	20	3774	c.3540C>T	c.(3538-3540)ttC>ttT	p.F1180F	PCNXL2_ENST00000488780.2_Silent_p.F313F|PCNXL2_ENST00000520463.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1180						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				AGAGTCTTTCGAACCACATTA	0.323000													30	11					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214670	161214670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161214670C>T	ENST00000327928.4	+	1	75	c.75C>T	c.(73-75)acC>acT	p.T25T		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	25						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						TAGCAAAGACCACACCACATA	0.393000													7	14					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125397960	125397960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:125397960C>T	ENST00000521654.2	+	4	1439	c.1439C>T	c.(1438-1440)cCa>cTa	p.P480L	RNF217_ENST00000359704.2_Missense_Mutation_p.P188L|RNF217_ENST00000275184.6_Missense_Mutation_p.P124L|RNF217_ENST00000560949.1_Missense_Mutation_p.P245L|RNF217_ENST00000368414.2_Missense_Mutation_p.P42L			Q8TC41	RN217_HUMAN	ring finger protein 217	188					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		CGCTACCTCCCAGAGAGACCT	0.438000													49	88					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1650748	1650748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:1650748C>T	ENST00000324015.3	+	7	734	c.657C>T	c.(655-657)ttC>ttT	p.F219F	SERPINF2_ENST00000450523.2_Silent_p.F155F|SERPINF2_ENST00000382061.4_Silent_p.F219F	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	219					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TTCAGGAATTCCTCTCTGGGC	0.587000													10	13					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6063645	6063645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6063645C>T	ENST00000379959.3	-	4	552	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	IL2RA_ENST00000256876.6_Missense_Mutation_p.E127K|IL2RA_ENST00000379954.1_Intron	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	127	Sushi 2.				cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GGTGGAGGTTCCCTGCAGTGA	0.527000													22	63					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49633259	49633259	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49633259C>T	ENST00000334186.4	+	6	941	c.592C>T	c.(592-594)Ctt>Ttt	p.L198F	PPFIA3_ENST00000602351.1_Missense_Mutation_p.L198F	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	198						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GACTCTGAACCTTCGAGAACA	0.597000													6	55					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784984	9784984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9784984C>T	ENST00000304374.2	+	1	1727	c.1331C>T	c.(1330-1332)tCc>tTc	p.S444F		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	444					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TATCAGACGTCCCCAGATGGT	0.547000													30	55					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2690852	2690852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2690852C>T	ENST00000399655.1	+	14	2257	c.1992C>T	c.(1990-1992)atC>atT	p.I664I	CACNA1C_ENST00000399637.1_Silent_p.I664I|CACNA1C_ENST00000480911.1_Silent_p.I664I|CACNA1C_ENST00000335762.5_Silent_p.I689I|CACNA1C_ENST00000399603.1_Silent_p.I664I|CACNA1C_ENST00000399649.1_Silent_p.I664I|CACNA1C_ENST00000399595.1_Silent_p.I664I|CACNA1C_ENST00000399606.1_Silent_p.I664I|CACNA1C_ENST00000399601.1_Silent_p.I664I|CACNA1C_ENST00000399617.1_Silent_p.I664I|CACNA1C_ENST00000344100.3_Silent_p.I664I|CACNA1C_ENST00000399621.1_Silent_p.I664I|CACNA1C_ENST00000399629.1_Silent_p.I664I|CACNA1C_ENST00000327702.7_Silent_p.I664I|CACNA1C_ENST00000406454.3_Silent_p.I664I|CACNA1C_ENST00000402845.3_Silent_p.I664I|CACNA1C_ENST00000399597.1_Silent_p.I664I|CACNA1C_ENST00000347598.4_Silent_p.I664I|CACNA1C_ENST00000399641.1_Silent_p.I664I|CACNA1C_ENST00000399638.1_Silent_p.I664I|CACNA1C_ENST00000399644.1_Silent_p.I664I|CACNA1C_ENST00000399591.1_Silent_p.I664I|CACNA1C_ENST00000399634.1_Silent_p.I664I	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	664					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	tcatcatcatcttctccctcc	0.537000													10	24					0	0	1	0	0
SPINK13	153218	broad.mit.edu	37	5	147661689	147661689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147661689C>T	ENST00000512953.1	+	5	662	c.131C>T	c.(130-132)cCa>cTa	p.P44L	SPINK13_ENST00000511106.1_Missense_Mutation_p.P4L|SPINK13_ENST00000398450.4_Missense_Mutation_p.P44L|RP11-373N22.3_ENST00000501695.3_RNA			Q1W4C9	ISK13_HUMAN	serine peptidase inhibitor, Kazal type 13 (putative)	44	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			breast(2)|lung(3)	5						ATGTATATCCCACTGGACCCT	0.438000													36	111					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55794837	55794837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55794837C>T	ENST00000379665.2	+	1	624	c.525C>T	c.(523-525)ttC>ttT	p.F175F		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						TTGACCATTTCATCTGTGATT	0.438000													79	276					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815501	106815501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106815501C>T	ENST00000407775.2	+	8	3441	c.3191C>T	c.(3190-3192)tCc>tTc	p.S1064F	ZFPM2_ENST00000520492.1_Missense_Mutation_p.S932F|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S795F|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S932F|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	1064					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAGAACATTTCCCAGAATCCT	0.483000													8	27					0	0	1	0	0
VAC14	55697	broad.mit.edu	37	16	70820186	70820186	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70820186A>C	ENST00000261776.5	-	2	447	c.187T>G	c.(187-189)Tct>Gct	p.S63A		NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	63					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				GGGTGCTGAGACAGGGCAAAC	0.612000													33	76					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51975425	51975425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51975425C>T	ENST00000220478.3	+	4	594	c.191C>T	c.(190-192)cCa>cTa	p.P64L	SCG3_ENST00000542355.2_5'UTR	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	64					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		GAAAACAAGCCAGGTCAGAGC	0.338000													91	216					0	0	1	0	0
IFNW1	3467	broad.mit.edu	37	9	21141378	21141378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21141378C>T	ENST00000380229.2	-	1	766	c.192G>A	c.(190-192)gaG>gaA	p.E64E		NM_002177.1	NP_002168.1	P05000	IFNW1_HUMAN	interferon, omega 1	64					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)	5				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTTTTACCATCTCCTGGGGGA	0.527000													48	77					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181732596	181732596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181732596C>T	ENST00000526775.1	+	33	4852	c.4687C>T	c.(4687-4689)Cgc>Tgc	p.R1563C	CACNA1E_ENST00000367567.4_Missense_Mutation_p.R1189C|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1514C|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R1582C|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R1563C|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R1582C|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R1533C	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1582					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCGAGCTGCCCGCCTCATAAA	0.468000													26	44					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10265056	10265056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10265056G>A	ENST00000340748.4	-	21	2119	c.1884C>T	c.(1882-1884)ttC>ttT	p.F628F	DNMT1_ENST00000540357.1_Silent_p.F628F|DNMT1_ENST00000359526.4_Silent_p.F644F			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	628					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	AGAAAGTATCGAAGATCTGGT	0.562000													36	156					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189904209	189904209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189904209C>T	ENST00000374866.3	-	51	3988	c.3714G>A	c.(3712-3714)ggG>ggA	p.G1238G		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1238					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CATCATAGTGCCCCATGATAT	0.547000													8	30					0	0	1	0	0
LHFPL4	375323	broad.mit.edu	37	3	9547825	9547825	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9547825C>T	ENST00000287585.6	-	3	754	c.469G>A	c.(469-471)Gac>Aac	p.D157N		NM_198560.2	NP_940962.1	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4	157						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(3)|skin(1)	10	Medulloblastoma(99;0.227)					CCACACATGTCCCGGATGGTC	0.632000													10	84					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209807885	209807885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209807885G>A	ENST00000391911.1	-	5	860	c.471C>T	c.(469-471)ttC>ttT	p.F157F	LAMB3_ENST00000356082.4_Silent_p.F157F|LAMB3_ENST00000367030.3_Silent_p.F157F	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	157	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGACCCGAGGGAAGGTGGAGG	0.637000													27	64					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921783	78921783	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78921783G>A	ENST00000261751.3	-	5	975	c.864C>T	c.(862-864)acC>acT	p.T288T	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	288					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CATCGAGGGAGGTGGGTGGCA	0.567000													21	74					0	0	1	0	0
SLC16A1	6566	broad.mit.edu	37	1	113460565	113460565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113460565G>A	ENST00000538576.1	-	4	1294	c.463C>T	c.(463-465)Cct>Tct	p.P155S	SLC16A1_ENST00000369626.3_Missense_Mutation_p.P155S|SLC16A1_ENST00000433570.4_Missense_Mutation_p.P155S	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	155					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	AGGAACACAGGGCTGCCTGCC	0.507000													23	71					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41516650	41516650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41516650C>T	ENST00000400454.1	-	17	3504	c.3027G>A	c.(3025-3027)aaG>aaA	p.K1009K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1009	Fibronectin type-III 2.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCAAATGTTTCTTGGGAGCCT	0.443000													14	56					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	56977725	56977725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:56977725G>A	ENST00000371250.3	-	5	1284	c.733C>T	c.(733-735)Cgc>Tgc	p.R245C	PPAP2B_ENST00000459962.1_5'UTR	NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	245					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						TCTGATACGCGAGACAGTCCC	0.572000													13	53					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31133838	31133838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31133838C>T	ENST00000349752.5	-	15	2227	c.1588G>A	c.(1588-1590)Ggc>Agc	p.G530S	GALNT14_ENST00000420311.2_Missense_Mutation_p.G495S|GALNT14_ENST00000406653.1_Missense_Mutation_p.G510S|GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000356174.3_Missense_Mutation_p.G497S|GALNT14_ENST00000324589.5_Missense_Mutation_p.G535S	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	530	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					ATTTCCTTGCCGTTCTCGGTG	0.537000													31	63					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98666301	98666301	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:98666301C>T	ENST00000261574.5	+	22	2392	c.2212C>T	c.(2212-2214)Cga>Tga	p.R738*	IPO5_ENST00000490680.1_Nonsense_Mutation_p.R720*|IPO5_ENST00000539640.1_Nonsense_Mutation_p.R595*	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	720					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						GAAACGTGTTCGAGTGGCAGC	0.433000													38	120					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53809900	53809900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:53809900G>A	ENST00000396328.1	-	20	3544	c.3305C>T	c.(3304-3306)tCt>tTt	p.S1102F	WDR72_ENST00000559418.1_Missense_Mutation_p.S1112F|WDR72_ENST00000360509.5_Missense_Mutation_p.S1102F|WDR72_ENST00000557913.1_Missense_Mutation_p.S1099F|WDR72_ENST00000567224.1_5'UTR	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	1102										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTCCATTTAAGACACCTTGCA	0.368000													37	99					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100433464	100433464	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100433464G>A	ENST00000279907.7	-	20	4397	c.4185C>T	c.(4183-4185)gtC>gtT	p.V1395V	UHRF1BP1L_ENST00000545232.2_Silent_p.V1045V	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1395										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						TGGCTTGCGTGACACTGCGTT	0.458000													17	55					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247607363	247607363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247607363G>A	ENST00000366497.2	+	7	3368	c.2588G>A	c.(2587-2589)cGa>cAa	p.R863Q	NLRP3_ENST00000366496.2_Missense_Mutation_p.R863Q|NLRP3_ENST00000336119.3_Missense_Mutation_p.R920Q|NLRP3_ENST00000348069.2_Missense_Mutation_p.R806Q|NLRP3_ENST00000391828.3_Missense_Mutation_p.R920Q|NLRP3_ENST00000391827.2_Missense_Mutation_p.R863Q	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	920					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTTTACCTGCGAGGCAACACT	0.493000													22	62					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182363398	182363398	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182363398C>T	ENST00000397033.2	+	15	2019	c.1589C>T	c.(1588-1590)cCa>cTa	p.P530L		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	530					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GCAGAGTCTCCACCAAGATTC	0.348000													18	60					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28543050	28543050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28543050C>T	ENST00000452236.2	-	3	2049	c.1432G>A	c.(1432-1434)Gat>Aat	p.D478N		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	478	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TTTCGGATATCCTCAGTTTGT	0.428000													36	79					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34773187	34773187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34773187G>A	ENST00000338074.2	+	7	876	c.715G>A	c.(715-717)Gag>Aag	p.E239K	EPB41L1_ENST00000202028.5_Missense_Mutation_p.E177K|EPB41L1_ENST00000373941.1_Missense_Mutation_p.E239K|EPB41L1_ENST00000441639.1_Missense_Mutation_p.E177K|EPB41L1_ENST00000373946.3_Missense_Mutation_p.E208K|EPB41L1_ENST00000373950.2_Missense_Mutation_p.E142K	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	239	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					CTATGTCAGCGAGCTCCGCTT	0.587000													17	46					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622451	74622451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74622451C>T	ENST00000156626.7	-	6	1534	c.1335G>A	c.(1333-1335)ctG>ctA	p.L445L		NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	445					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GGGTGCCTTCCAGGAAGTGCA	0.562000													22	55					0	0	1	0	0
SPI1	6688	broad.mit.edu	37	11	47380496	47380496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47380496G>A	ENST00000378538.3	-	4	614	c.392C>T	c.(391-393)tCa>tTa	p.S131L	SPI1_ENST00000533968.1_Missense_Mutation_p.S131L|SPI1_ENST00000533030.1_Intron|SPI1_ENST00000227163.4_Missense_Mutation_p.S132L	NM_001080547.1|NM_003120.2	NP_001074016.1|NP_003111.2	P17947	SPI1_HUMAN	spleen focus forming virus (SFFV) proviral integration oncogene	131					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of erythrocyte differentiation	nucleus	protein binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(4)|ovary(1)	8				Lung(87;0.0967)		CTCCTCATCTGAGCTGGGCTG	0.692000													5	4					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143310846	143310846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143310846C>T	ENST00000524325.1	-	13	1713	c.1538G>A	c.(1537-1539)tGa>tAa	p.*513*	TSNARE1_ENST00000520166.1_Silent_p.*514*|TSNARE1_ENST00000307180.3_Silent_p.*514*			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	0					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CGGGTAGCATCACTTTCGGAC	0.517000													16	46					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35709136	35709136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35709136C>T	ENST00000440995.2	+	19	2737	c.2737C>T	c.(2737-2739)Cct>Tct	p.P913S	SPEF2_ENST00000356031.3_Missense_Mutation_p.P918S|CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000509059.1_Missense_Mutation_p.P913S			Q9C093	SPEF2_HUMAN	sperm flagellar 2	918					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCCTCCTGCTCCTCCTCCTGA	0.433000													27	85					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424057	56424057	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56424057C>T	ENST00000588751.1	-	5	1150	c.1126G>A	c.(1126-1128)Gtg>Atg	p.V376M	NLRP13_ENST00000342929.3_Missense_Mutation_p.V376M			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	376	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CATGGATTCACTAATGAGGCC	0.423000													45	94					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71839802	71839802	+	Missense_Mutation	SNP	C	C	T	rs138268837		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71839802C>T	ENST00000258104.3	+	39	4476	c.4199C>T	c.(4198-4200)cCc>cTc	p.P1400L	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Missense_Mutation_p.P1401L|DYSF_ENST00000409744.1_Missense_Mutation_p.P1387L|DYSF_ENST00000410020.3_Missense_Mutation_p.P1418L|DYSF_ENST00000413539.2_Missense_Mutation_p.P1431L|DYSF_ENST00000429174.2_Missense_Mutation_p.P1400L|DYSF_ENST00000409366.1_Missense_Mutation_p.P1401L|DYSF_ENST00000409582.3_Missense_Mutation_p.P1417L|DYSF_ENST00000409762.1_Missense_Mutation_p.P1417L|DYSF_ENST00000409651.1_Missense_Mutation_p.P1432L|DYSF_ENST00000410041.1_Missense_Mutation_p.P1418L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1400						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TACTGCCCCCCCATCACCGTC	0.622000													26	81					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19120895	19120895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19120895G>A	ENST00000601879.1	-	5	2404	c.2107C>T	c.(2107-2109)Ctc>Ttc	p.L703F	SUGP2_ENST00000337018.6_Missense_Mutation_p.L703F|SUGP2_ENST00000452918.2_Missense_Mutation_p.L703F|SUGP2_ENST00000456085.2_Missense_Mutation_p.L472F|SUGP2_ENST00000600377.1_Missense_Mutation_p.L717F			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	703					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						GAGGATAGGAGGGTCTGGGTC	0.642000													33	104					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43439821	43439821	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43439821G>A	ENST00000446844.3	-	0	254				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GCAAATTGTGGACAAGTAGAA	0.453000													105	204					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128324337	128324337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128324337G>A	ENST00000262462.4	+	3	1740	c.730G>A	c.(730-732)Ggt>Agt	p.G244S	SLC27A6_ENST00000395266.1_Missense_Mutation_p.G244S|SLC27A6_ENST00000506176.1_Missense_Mutation_p.G244S			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	244					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GGTTTTAAGGGGTTCTGCTGT	0.398000													53	126					0	0	1	0	0
CST4	1472	broad.mit.edu	37	20	23667824	23667824	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23667824C>T	ENST00000217423.3	-	2	313	c.243G>A	c.(241-243)gtG>gtA	p.V81V		NM_001899.2	NP_001890.1	P01036	CYTS_HUMAN	cystatin S	81						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	16	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					AGAAGTAATTCACCCCCCCAA	0.557000													49	184					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93065419	93065419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:93065419C>T	ENST00000359558.2	-	14	1395	c.1096G>A	c.(1096-1098)Gag>Aag	p.E366K	CALCR_ENST00000426151.1_Missense_Mutation_p.E332K|CALCR_ENST00000360249.4_Missense_Mutation_p.E348K|CALCR_ENST00000394441.1_Missense_Mutation_p.E332K|CALCR_ENST00000421592.1_Missense_Mutation_p.E348K	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	348					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GATTCCGCCTCATGGGTTTCC	0.478000													21	56					0	0	1	0	0
AQP2	359	broad.mit.edu	37	12	50344655	50344655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50344655C>T	ENST00000199280.3	+	1	127	c.42C>T	c.(40-42)ttC>ttT	p.F14F		NM_000486.5	NP_000477.1	P41181	AQP2_HUMAN	aquaporin 2 (collecting duct)	14					cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(4)|ovary(2)	10						GGGCTGTGTTCGCAGAGTTCC	0.642000													24	40					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15561637	15561637	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:15561637C>T	ENST00000344577.2	-	2	238	c.213G>A	c.(211-213)agG>agA	p.R71R	LIPI_ENST00000536861.1_Silent_p.R50R	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	50					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTAGGTTGTTCCTTGTATACA	0.353000													29	101					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41853402	41853402	+	Missense_Mutation	SNP	G	G	A	rs148972694	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41853402G>A	ENST00000263798.3	+	2	426	c.202G>A	c.(202-204)Ggg>Agg	p.G68R	TYRO3_ENST00000559066.1_Missense_Mutation_p.G23R	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	68	Ig-like C2-type 1.					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CAGTGTGGAGGGGATGGAGGA	0.592000													8	72					0	0	1	0	0
ZNF235	9310	broad.mit.edu	37	19	44791515	44791515	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44791515G>A	ENST00000291182.4	-	5	2175	c.2073C>T	c.(2071-2073)ggC>ggT	p.G691G	ZNF235_ENST00000589799.1_Intron|ZNF235_ENST00000589248.1_Intron	NM_004234.4	NP_004225.3	Q14590	ZN235_HUMAN	zinc finger protein 235	691					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29		Prostate(69;0.0352)|all_neural(266;0.116)				CCTGACTGAAGCCCTTCCCAC	0.512000													24	98					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637427	248637427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248637427C>T	ENST00000359594.2	+	1	801	c.776C>T	c.(775-777)gCt>gTt	p.A259V		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCTTCGGTGCTTCCTTCTAC	0.552000													102	353					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75102019	75102019	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75102019G>A	ENST00000326665.5	-	6	766	c.548C>T	c.(547-549)tCa>tTa	p.S183L		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	183										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCTGGACCTTGAAGTTACCTT	0.388000													66	201					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103068633	103068633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103068633G>A	ENST00000264260.2	+	12	2381	c.1792G>A	c.(1792-1794)Gaa>Aaa	p.E598K	IL18RAP_ENST00000409369.1_Missense_Mutation_p.E456K	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	598					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						CCAGCCTAAGGAATGGTGAAA	0.517000													40	77					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49701640	49701640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:49701640C>T	ENST00000303221.5	-	5	734	c.519G>A	c.(517-519)ggG>ggA	p.G173G	EMB_ENST00000508934.1_Silent_p.G119G|EMB_ENST00000514111.1_Silent_p.G123G|EMB_ENST00000506190.1_5'UTR	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	173	Ig-like V-type 2.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				CAGTAGAATCCCCTACGTAAG	0.348000													32	53					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940104	68940104	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:68940104G>A	ENST00000433211.1	-	7	1192	c.1018C>T	c.(1018-1020)Cag>Tag	p.Q340*	CTNNA3_ENST00000494580.1_5'UTR|CTNNA3_ENST00000545309.1_Nonsense_Mutation_p.Q340*|CTNNA3_ENST00000373744.4_Nonsense_Mutation_p.Q340*	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	340					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						AGCAGATCCTGAAGAGCCTGG	0.502000													18	63					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263531	140263531	+	Missense_Mutation	SNP	G	G	A	rs139225969	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140263531G>A	ENST00000289272.2	+	1	1678	c.1678G>A	c.(1678-1680)Gac>Aac	p.D560N	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.D560N|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGAGAACGACAACGCTCC	0.697000													47	114					0	0	1	0	0
CYP1A1	1543	broad.mit.edu	37	15	75015177	75015177	+	Missense_Mutation	SNP	C	C	T	rs77425771		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75015177C>T	ENST00000379727.3	-	2	460	c.262G>A	c.(262-264)Ggc>Agc	p.G88S	CYP1A1_ENST00000395049.4_Missense_Mutation_p.G88S|CYP1A1_ENST00000567032.1_Missense_Mutation_p.G88S|CYP1A1_ENST00000395048.2_Missense_Mutation_p.G88S|CYP1A1_ENST00000564596.1_Intron			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	88					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	GTGTCCAGGCCGCTCAGCACC	0.617000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				20	67					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201196111	201196111	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201196111G>A	ENST00000335211.4	+	23	11018	c.10888G>A	c.(10888-10890)Gag>Aag	p.E3630K	IGFN1_ENST00000295591.8_3'UTR	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CCAGGGCTGCGAGTGCTGCAT	0.677000													45	81					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43606197	43606197	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43606197G>A	ENST00000360835.3	-	19	2559	c.2433C>T	c.(2431-2433)tcC>tcT	p.S811S		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	811	CUB.				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GGTAGTTGGGGGACTCGATGT	0.652000													15	34					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924639	188924639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:188924639C>T	ENST00000326866.4	+	4	1086	c.678C>T	c.(676-678)ttC>ttT	p.F226F	ZFP42_ENST00000509524.1_Silent_p.F226F	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	226					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GGAAAGCGTTCGTTGAGAGCT	0.507000													30	76					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124952521	124952521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124952521G>A	ENST00000360647.4	-	9	1534	c.1049C>T	c.(1048-1050)tCt>tTt	p.S350F	ZNF148_ENST00000544464.1_Intron|ZNF148_ENST00000492394.1_Missense_Mutation_p.S350F|SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000497929.1_5'UTR|ZNF148_ENST00000484491.1_Missense_Mutation_p.S350F|ZNF148_ENST00000485866.1_Missense_Mutation_p.S350F|ZNF148_ENST00000468369.1_Intron	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	350					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						AGTACTTGAAGAATAAAGAGG	0.388000													33	120					0	0	1	0	0
GRB7	2886	broad.mit.edu	37	17	37898852	37898852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37898852C>T	ENST00000309156.4	+	3	446	c.189C>T	c.(187-189)tcC>tcT	p.S63S	GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000394204.1_Silent_p.S63S|GRB7_ENST00000394209.2_Silent_p.S63S|GRB7_ENST00000309185.3_Silent_p.S63S|GRB7_ENST00000445327.2_Silent_p.S86S|GRB7_ENST00000394211.3_Silent_p.S63S	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	63					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GTGCCACCTCCCTCCCCTCTA	0.627000													63	90					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48603334	48603334	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48603334G>A	ENST00000323776.5	+	14	2166	c.2004G>A	c.(2002-2004)ggG>ggA	p.G668G	MYCBPAP_ENST00000436259.2_Silent_p.G631G	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	631					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CCAGGCCAGGGGACAAGGAGC	0.597000													38	143					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55047005	55047005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55047005C>T	ENST00000335056.3	+	4	588	c.550C>T	c.(550-552)Cct>Tct	p.P184S	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		TTCCATGGGTCCTGTAACGCC	0.537000													25	72					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625129	74625129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74625129C>T	ENST00000156626.7	-	2	995	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K	ST6GALNAC1_ENST00000590878.1_5'UTR	NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	266					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						CTGTATTTTTCCTCAAAATCC	0.577000													48	99					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39442854	39442854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39442854G>A	ENST00000265707.5	+	2	160	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.E39K|ADAM18_ENST00000520772.1_Missense_Mutation_p.E39K	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	39					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AAATGACAGTGAAGTTTCAGA	0.313000													25	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179614236	179614236	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179614236C>T	ENST00000360870.5	-	46	13113	c.12891G>A	c.(12889-12891)tgG>tgA	p.W4297*	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	430	Ig-like 23.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACATTTGTCCAGGGAGTAA	0.398000													23	50					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119115959	119115959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119115959C>T	ENST00000328252.3	+	17	4603	c.4234C>T	c.(4234-4236)Cct>Tct	p.P1412S	PAPPA_ENST00000534838.1_Missense_Mutation_p.P450S	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1412	Sushi 3.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						AGCTTGTGTTCCTGTGACCTG	0.507000													44	76					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216243581	216243581	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216243581T>C	ENST00000366943.2	-	30	6297	c.5911A>G	c.(5911-5913)Att>Gtt	p.I1971V	USH2A_ENST00000307340.3_Missense_Mutation_p.I1971V			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1971	Fibronectin type-III 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTCACCTCAATGCTGTATCCA	0.478000										HNSCC(13;0.011)			26	52					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54603833	54603833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54603833G>A	ENST00000474759.1	+	7	736	c.688G>A	c.(688-690)Gaa>Aaa	p.E230K	CACNA2D3_ENST00000415676.2_Missense_Mutation_p.E230K|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.E230K|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.E136K	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	230						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GATTAAATGGGAACCAGATGA	0.393000													6	13					0	0	1	0	0
CDC25C	995	broad.mit.edu	37	5	137665307	137665307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137665307G>A	ENST00000323760.6	-	3	502	c.224C>T	c.(223-225)tCg>tTg	p.S75L	CDC25C_ENST00000357274.3_Intron|CDC25C_ENST00000513970.1_Missense_Mutation_p.S75L|CDC25C_ENST00000356505.3_Missense_Mutation_p.S75L|CDC25C_ENST00000514555.1_Missense_Mutation_p.S75L|CDC25C_ENST00000348983.3_Intron|CDC25C_ENST00000415130.2_Intron	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	75					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GCTAAGATTCGAAAGATCGAG	0.423000													51	124					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98189116	98189116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98189116G>A	ENST00000332650.5	+	1	793	c.696G>A	c.(694-696)gaG>gaA	p.E232E		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AATCCAAAGAGGGAAGGGCCA	0.343000													42	97					0	0	1	0	0
SPINK7	84651	broad.mit.edu	37	5	147693757	147693757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147693757G>A	ENST00000274565.4	+	3	243	c.182G>A	c.(181-183)gGg>gAg	p.G61E	SPINK7_ENST00000523535.1_Missense_Mutation_p.G35E|SPINK7_ENST00000514394.1_3'UTR|RP11-373N22.3_ENST00000501695.3_RNA	NM_032566.2	NP_115955.1	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7 (putative)	61	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCACCTATGGGAATGAATGT	0.463000													16	123					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358659	72358659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72358659G>A	ENST00000441259.1	-	3	978	c.818C>T	c.(817-819)tCt>tTt	p.S273F	PRF1_ENST00000373209.2_Missense_Mutation_p.S273F	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	273	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						GGCTTCGGCAGAGATGCTGCC	0.622000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				24	86					0	0	1	0	0
SLC1A2	6506	broad.mit.edu	37	11	35339031	35339031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:35339031C>T	ENST00000278379.3	-	2	332	c.50G>A	c.(49-51)cGa>cAa	p.R17Q	SLC1A2_ENST00000395750.1_Missense_Mutation_p.R8Q|SLC1A2_ENST00000395753.1_Missense_Mutation_p.R8Q|SLC1A2_ENST00000606205.1_Missense_Mutation_p.R17Q	NM_004171.3	NP_004162.2	P43004	EAA2_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 2	17					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|urinary_tract(1)	24	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	GTCGTGCATTCGCACTTCCAC	0.567000													88	117					0	0	1	0	0
ALG9	79796	broad.mit.edu	37	11	111708198	111708198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111708198G>A	ENST00000398006.2	-	12	1839	c.931C>T	c.(931-933)Cct>Tct	p.P311S	ALG9_ENST00000531154.1_Missense_Mutation_p.P318S|ALG9_ENST00000527228.1_5'UTR|ALG9_ENST00000524880.1_3'UTR	NM_001077690.1|NM_001077691.1|NM_001077692.1	NP_001071158.1|NP_001071159.1|NP_001071160.1	Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	482					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		TACTTGTCAGGAAGAAGGAAG	0.408000													24	52					0	0	1	0	0
LALBA	3906	broad.mit.edu	37	12	48963801	48963801	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48963801C>T	ENST00000549817.1	-	1	48	c.3G>A	c.(1-3)atG>atA	p.M1I	LALBA_ENST00000301046.2_Start_Codon_SNP_p.M1I			P00709	LALBA_HUMAN	lactalbumin, alpha-	1					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity			large_intestine(1)|stomach(2)	3						CAAAGAACCTCATTTTGGCTA	0.483000													41	81					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40728919	40728919	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40728919C>T	ENST00000298910.7	+	40	5966	c.5908C>T	c.(5908-5910)Cta>Tta	p.L1970L		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1970	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CACTAGAACCCTACAGCACAG	0.517000													19	62					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98512567	98512567	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:98512567C>T	ENST00000268042.6	+	5	1004	c.840C>T	c.(838-840)tcC>tcT	p.S280S	ARRDC4_ENST00000538249.1_Silent_p.S193S	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	280					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TTACTCCATCCATCCTGGATT	0.428000													60	59					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61602272	61602272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61602272C>T	ENST00000238508.3	+	8	1049	c.990C>T	c.(988-990)aaC>aaT	p.N330N	AC009802.1_ENST00000599868.1_Intron	NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				CAGCAAGAAACCTATTTTTGT	0.413000													30	55					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119926647	119926647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119926647C>T	ENST00000327554.2	+	5	998	c.533C>T	c.(532-534)cCt>cTt	p.P178L	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	178										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		ACCATGAAGCCTGTGATCACC	0.547000													26	60					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143995719	143995719	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143995719C>A	ENST00000323110.2	-	5	917	c.915G>T	c.(913-915)aaG>aaT	p.K305N		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	305					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TAGAGTTGGCCTTGATGGCTT	0.587000									Familial Hyperaldosteronism type I				17	24					1.00905e-13	1.01423e-13	1	1	0
TIAM2	26230	broad.mit.edu	37	6	155458470	155458470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155458470G>A	ENST00000461783.3	+	7	2627	c.1354G>A	c.(1354-1356)Gat>Aat	p.D452N	TIAM2_ENST00000456144.1_Missense_Mutation_p.D452N|TIAM2_ENST00000318981.5_Missense_Mutation_p.D452N|TIAM2_ENST00000360366.4_Missense_Mutation_p.D452N|TIAM2_ENST00000529824.2_Missense_Mutation_p.D452N|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	452					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GATTGGCAGCGATCCCCTCCG	0.502000													53	50					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38776168	38776168	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:38776168C>T	ENST00000308973.4	-	4	1649	c.1044G>A	c.(1042-1044)acG>acA	p.T348T	TLR10_ENST00000506111.1_Silent_p.T348T|TLR10_ENST00000508334.1_Silent_p.T348T|TLR10_ENST00000361424.2_Silent_p.T348T	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	348					inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity	p.T348T(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						ATTGGAATTTCGTAGGATAAT	0.328000													38	113					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72040764	72040764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72040764C>T	ENST00000355327.3	+	14	2380	c.2246C>T	c.(2245-2247)tCg>tTg	p.S749L	THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000357769.4_Missense_Mutation_p.S389L|THSD4_ENST00000261862.6_Missense_Mutation_p.S749L			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	749	TSP type-1 3.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TTTCAGTGCTCGGTGCCCTGC	0.577000													13	66					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42231188	42231188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42231188G>A	ENST00000541110.1	-	8	2322	c.1754C>T	c.(1753-1755)cCc>cTc	p.P585L	TRERF1_ENST00000354325.2_Intron|TRERF1_ENST00000340840.2_Intron|TRERF1_ENST00000372917.4_Intron|TRERF1_ENST00000372922.4_Missense_Mutation_p.P585L			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	585	Interacts with CREBBP.|Pro-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GACAGACACGGGCATGACCAT	0.692000													21	70					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46609673	46609673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:46609673C>T	ENST00000263734.3	+	15	2907	c.2397C>T	c.(2395-2397)ttC>ttT	p.F799F		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	799					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AGAGCAGGTTCCCCCCACAGT	0.637000													24	84					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89939785	89939785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89939785G>A	ENST00000405460.2	+	14	2815	c.2719G>A	c.(2719-2721)Gat>Aat	p.D907N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	907					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGCAAAGGAGATGCTATCTA	0.274000													5	19					0	0	1	0	0
CD276	80381	broad.mit.edu	37	15	73996519	73996519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73996519C>T	ENST00000318443.5	+	6	1377	c.1075C>T	c.(1075-1077)Ccc>Tcc	p.P359S	CD276_ENST00000318424.5_Missense_Mutation_p.P141S|CD276_ENST00000537340.2_Missense_Mutation_p.P213S|CD276_ENST00000561213.1_Missense_Mutation_p.P359S|CD276_ENST00000564751.1_Missense_Mutation_p.P141S	NM_001024736.1	NP_001019907.1	Q5ZPR3	CD276_HUMAN	CD276 molecule	359					cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						ACCTCCAGCTCCCTACTCGAA	0.637000													6	22					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156929952	156929952	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156929952C>T	ENST00000257527.4	-	12	1245	c.1167G>A	c.(1165-1167)agG>agA	p.R389R	ADAM19_ENST00000394020.1_Silent_p.R391R|ADAM19_ENST00000430702.2_Silent_p.R122R|ADAM19_ENST00000517905.1_Silent_p.R389R	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	389	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCAGCTCCCTCCTGTTGCATC	0.552000													38	81					0	0	1	0	0
P2RX7	5027	broad.mit.edu	37	12	121593887	121593887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121593887C>T	ENST00000546057.1	+	3	443	c.300C>T	c.(298-300)aaC>aaT	p.N100N	P2RX7_ENST00000541446.1_5'UTR|P2RX7_ENST00000377162.2_Silent_p.N100N|P2RX7_ENST00000328963.5_5'UTR|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000535250.1_Silent_p.N10N	NM_002562.5	NP_002553.3	A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	100						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CACAGGGGAACTCTTTCTTCG	0.473000													39	95					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79733273	79733273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79733273C>T	ENST00000338008.5	+	3	949	c.769C>T	c.(769-771)Cat>Tat	p.H257Y	ZFYVE16_ENST00000505560.1_Missense_Mutation_p.H257Y|ZFYVE16_ENST00000510158.1_Missense_Mutation_p.H257Y	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	257					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		CAAAATGTTTCATGCCAAAGA	0.353000													26	94					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	175995723	175995723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:175995723C>T	ENST00000510636.1	+	4	443	c.169C>T	c.(169-171)Cct>Tct	p.P57S	CDHR2_ENST00000261944.5_Missense_Mutation_p.P57S|CDHR2_ENST00000506348.1_Missense_Mutation_p.P57S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	57	Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GGACAATGACCCTCTGACCTA	0.597000													16	80					0	0	1	0	0
C1orf141	400757	broad.mit.edu	37	1	67559037	67559037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:67559037G>A	ENST00000371007.2	-	8	963	c.854C>T	c.(853-855)tCt>tTt	p.S285F	C1orf141_ENST00000371006.1_Missense_Mutation_p.S285F|C1orf141_ENST00000544837.1_Missense_Mutation_p.S285F	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	285										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						CGCTTTAAAAGACATAGGGAT	0.333000													25	107					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53207919	53207919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53207919C>T	ENST00000293774.4	-	1	416	c.146G>A	c.(145-147)cGa>cAa	p.R49Q	KRT4_ENST00000551956.1_5'UTR			B4DRS2	B4DRS2_HUMAN	keratin 4	0						keratin filament	structural molecule activity	p.R49P(1)		endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CCTCAGCCTTCGTCTCTTATA	0.567000													6	44					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55352346	55352346	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:55352346C>T	ENST00000536015.1	-	14	1550	c.1429_splice	c.e14-1	p.G477_splice	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Splice_Site_p.G477_splice|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	477					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				CCCGATGGTCCCCTGAGAAAC	0.473000													9	123					0	0	1	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181538	128181538	+	Missense_Mutation	SNP	G	G	A	rs140414363		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:128181538G>A	ENST00000469083.1	-	2	3108	c.551C>T	c.(550-552)tCg>tTg	p.S184L	DNAJB8_ENST00000319153.3_Missense_Mutation_p.S184L			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	184					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		CTCGGTGGACGACATCACCGA	0.622000													37	70					0	0	1	0	0
ARHGAP19-SLIT1	100533184	broad.mit.edu	37	10	98995059	98995059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98995059G>A	ENST00000453547.2	-	9	1198	c.1199C>T	c.(1198-1200)tCa>tTa	p.S400L	ARHGAP19_ENST00000358531.4_Missense_Mutation_p.S400L|ARHGAP19_ENST00000371027.1_Missense_Mutation_p.S391L|ARHGAP19-SLIT1_ENST00000316676.8_Missense_Mutation_p.S400L|ARHGAP19-SLIT1_ENST00000358308.3_Missense_Mutation_p.S371L|ARHGAP19_ENST00000487035.1_5'UTR|ARHGAP19_ENST00000355366.5_Missense_Mutation_p.S391L																							CTGGGTCAATGATTGCTTATT	0.418000													43	109					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60768077	60768077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60768077G>A	ENST00000303375.5	+	27	4369	c.3967G>A	c.(3967-3969)Ggc>Agc	p.G1323S	MRC2_ENST00000446119.2_Missense_Mutation_p.G189S	NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1323	C-type lectin 8.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GAGCTATGAGGGCCAGAGTCG	0.612000													18	48					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870938	51870938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51870938C>T	ENST00000371497.5	+	2	1828	c.941C>T	c.(940-942)tCg>tTg	p.S314L	TSHZ2_ENST00000329613.6_Missense_Mutation_p.S311L|TSHZ2_ENST00000603338.2_Missense_Mutation_p.S311L	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	314					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			ACCATTTCCTCGAAAATGGTC	0.458000													10	100					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45802612	45802612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45802612C>T	ENST00000397928.1	+	9	1672	c.1227C>T	c.(1225-1227)atC>atT	p.I409I	TRPM2_ENST00000397932.2_Silent_p.I409I|TRPM2_ENST00000300482.5_Silent_p.I409I|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Silent_p.I409I	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	409						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TCCAAGATATCGTCCGGAGGC	0.562000													7	24					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155450443	155450443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155450443C>T	ENST00000461783.3	+	6	1359	c.86C>T	c.(85-87)tCc>tTc	p.S29F	TIAM2_ENST00000456144.1_Missense_Mutation_p.S29F|TIAM2_ENST00000318981.5_Missense_Mutation_p.S29F|TIAM2_ENST00000360366.4_Missense_Mutation_p.S29F|TIAM2_ENST00000529824.2_Missense_Mutation_p.S29F|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	29					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		ATTCCTTGCTCCCTGAAAATA	0.448000													18	52					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154543767	154543767	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154543767G>A	ENST00000368476.3	+	5	732	c.468G>A	c.(466-468)aaG>aaA	p.K156K		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	156					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity	p.K156N(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	GCGCATGCAAGATTGAAGTAA	0.527000													38	53					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147900526	147900526	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147900526C>T	ENST00000362016.2	-	6	671	c.507_splice	c.e6-1	p.E170_splice	HTR4_ENST00000360693.3_Intron|HTR4_ENST00000521530.1_Intron|HTR4_ENST00000520514.1_Intron|HTR4_ENST00000521735.1_Intron|HTR4_ENST00000354217.2_Intron|HTR4_ENST00000314512.6_Intron|HTR4_ENST00000517929.1_Intron|HTR4_ENST00000377888.3_Intron			Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	169					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AGACTCCTTTCCTTGAAAAAG	0.478000													25	53					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37673727	37673727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37673727C>T	ENST00000447079.4	+	10	2914	c.2881C>T	c.(2881-2883)Cct>Tct	p.P961S	CDK12_ENST00000430627.2_Missense_Mutation_p.P961S	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	961	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						AGCTGTGTGGCCTGATGTTAT	0.448000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			53	114					0	0	1	0	0
AMHR2	269	broad.mit.edu	37	12	53823694	53823694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53823694G>A	ENST00000257863.4	+	9	1300	c.1220G>A	c.(1219-1221)cGa>cAa	p.R407Q	AMHR2_ENST00000550311.1_Missense_Mutation_p.R407Q|AMHR2_ENST00000379791.3_Intron	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	407	Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	GCCCTCCGACGAGCTGATATT	0.582000													19	52					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158577134	158577134	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158577134G>A	ENST00000361284.1	+	1	906	c.906G>A	c.(904-906)agG>agA	p.R302R		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					CAGCTCTGAGGAATGCTTTCA	0.458000													72	191					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238592	104238592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104238592C>T	ENST00000374851.1	-	4	1930	c.783G>A	c.(781-783)cgG>cgA	p.R261R	TMEM246_ENST00000374848.3_Silent_p.R261R|RP11-490D19.6_ENST00000424154.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000450109.1_RNA|TMEM246_ENST00000374847.1_Silent_p.R261R			Q9BRR3	CI125_HUMAN	transmembrane protein 246	261						integral to membrane											ATTCCAGGATCCGCATGGGCT	0.552000													61	71					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50958867	50958867	+	Silent	SNP	C	C	T	rs145465195	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50958867C>T	ENST00000357701.5	+	20	2355	c.2304C>T	c.(2302-2304)atC>atT	p.I768I		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	768	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle	p.I768I(1)		breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CAGGTGGCATCGATGGGTACC	0.622000													12	88					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170019096	170019096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170019096G>A	ENST00000263816.3	-	63	12058	c.11773C>T	c.(11773-11775)Cct>Tct	p.P3925S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3925					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAAGGTTTAGGGGTCGGTTTT	0.388000													21	61					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60696259	60696259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60696259C>T	ENST00000005286.4	+	4	846	c.693C>T	c.(691-693)gcC>gcT	p.A231A	TMEM132A_ENST00000453848.2_Silent_p.A231A	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	231						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GGGAGCAGGCCCTCCCAGTGG	0.701000													12	20					0	0	1	0	0
CXXC1	30827	broad.mit.edu	37	18	47812438	47812438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47812438G>A	ENST00000285106.6	-	4	1127	c.413C>T	c.(412-414)tCg>tTg	p.S138L	CXXC1_ENST00000412036.2_Missense_Mutation_p.S138L|CXXC1_ENST00000589940.1_Missense_Mutation_p.S138L	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	138					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						TTTGTGGGGCGAAGCAGAGCC	0.632000													27	71					0	0	1	0	0
STAT1	6772	broad.mit.edu	37	2	191874651	191874651	+	Missense_Mutation	SNP	G	G	A	rs11549696		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:191874651G>A	ENST00000361099.3	-	3	466	c.79C>T	c.(79-81)Ccc>Tcc	p.P27S	STAT1_ENST00000392322.3_Missense_Mutation_p.P27S|STAT1_ENST00000392323.2_Missense_Mutation_p.P29S|STAT1_ENST00000409465.1_Missense_Mutation_p.P27S|STAT1_ENST00000540176.1_Missense_Mutation_p.P27S	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	27					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	ATTTCCATGGGAAAACTGTCA	0.408000													10	186					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58111348	58111348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58111348C>T	ENST00000357272.4	+	23	4104	c.3939C>T	c.(3937-3939)atC>atT	p.I1313I	FLNB_ENST00000358537.3_Silent_p.I1313I|FLNB_ENST00000295956.4_Silent_p.I1313I|FLNB_ENST00000429972.2_Silent_p.I1313I|FLNB_ENST00000490882.1_Silent_p.I1313I|FLNB_ENST00000348383.5_Silent_p.I1313I|FLNB_ENST00000419752.2_Silent_p.I1144I|FLNB_ENST00000493452.1_Silent_p.I1144I			O75369	FLNB_HUMAN	filamin B, beta	1313	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ACGTGCCTATCCCAAACAGTC	0.473000													38	85					0	0	1	0	0
FBP2	8789	broad.mit.edu	37	9	97355969	97355969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:97355969G>A	ENST00000375337.3	-	1	106	c.40C>T	c.(40-42)Ctg>Ttg	p.L14L		NM_003837.2	NP_003828.2	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	14					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding			endometrium(1)|large_intestine(3)|lung(5)	9		Acute lymphoblastic leukemia(62;0.136)				TAGCGGGTCAGGGTGAGCATG	0.552000													12	51					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50052708	50052708	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50052708C>T	ENST00000376042.1	+	6	1837	c.1539C>T	c.(1537-1539)acC>acT	p.T513T	CCNB3_ENST00000276014.7_Silent_p.T513T|CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000376038.1_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	513					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TACAGACCACCTCTGGAGAAA	0.428000													7	27					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56954855	56954855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56954855C>T	ENST00000497933.1	+	2	1074	c.927C>T	c.(925-927)ttC>ttT	p.F309F		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	279	Poly-Glu.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						TCGTGGGCTTCGTGGTCTCCA	0.582000													20	68					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87645063	87645063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87645063C>T	ENST00000320005.5	-	11	1284	c.1237G>A	c.(1237-1239)Gaa>Aaa	p.E413K		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	413					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						GTTTGTGGTTCTGGAAGGCCA	0.323000													17	44					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234357778	234357778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234357778C>T	ENST00000264057.2	+	15	1656	c.1644C>T	c.(1642-1644)tcC>tcT	p.S548S	DGKD_ENST00000409813.3_Silent_p.S504S	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	548					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	AGCTGGATTCCCTTCTCAAGA	0.587000													57	144					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163241215	163241215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163241215C>T	ENST00000332142.5	-	13	3044	c.2945G>A	c.(2944-2946)aGa>aAa	p.R982K		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	982					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AGAGTGACTTCTTTTATCTAT	0.408000													13	162					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987389	61987389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61987389G>A	ENST00000450719.3	-	3	559	c.322C>T	c.(322-324)Ctc>Ttc	p.L108F	CSHL1_ENST00000346606.6_Intron|CSHL1_ENST00000561003.1_Missense_Mutation_p.L119F|CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000438387.2_Intron|CSHL1_ENST00000259003.10_Intron|CSHL1_ENST00000309894.5_Intron			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	0						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						GGATTCACGAGGGGAAATGAA	0.542000													43	110					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649270	75649270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:75649270C>T	ENST00000361470.2	+	1	1225	c.947C>T	c.(946-948)tCg>tTg	p.S316L		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	316	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						GGTGAGGGATCGAGCACCTCC	0.711000													4	19					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52308303	52308303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52308303G>A	ENST00000550683.1	+	5	849	c.748G>A	c.(748-750)Gaa>Aaa	p.E250K	ACVRL1_ENST00000388922.4_Missense_Mutation_p.E236K|ACVRL1_ENST00000419526.2_Missense_Mutation_p.E62K	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	236	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CTCGAGGGATGAACAGTCCTG	0.592000													13	25					0	0	1	0	0
ZNF345	25850	broad.mit.edu	37	19	37368402	37368402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37368402C>T	ENST00000529555.1	+	2	1458	c.670C>T	c.(670-672)Cat>Tat	p.H224Y	ZNF345_ENST00000589046.1_Missense_Mutation_p.H224Y|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000420450.1_Missense_Mutation_p.H224Y|ZNF345_ENST00000432005.2_Intron			Q14585	ZN345_HUMAN	zinc finger protein 345	224					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCGGCGGATTCATACTGGTGA	0.448000													7	109					0	0	1	0	0
KCTD17	79734	broad.mit.edu	37	22	37457582	37457582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37457582C>T	ENST00000403888.3	+	8	810	c.809C>T	c.(808-810)tCc>tTc	p.S270F	KCTD17_ENST00000402077.3_Missense_Mutation_p.S246F			Q8N5Z5	KCD17_HUMAN	potassium channel tetramerization domain containing 17	270	Pro-rich.					voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity			NS(1)|breast(1)|endometrium(1)|lung(1)|prostate(1)	5						CTTGCAGGTTCCCGTCCGCAC	0.677000													6	21					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	601394	601394	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:601394C>T	ENST00000219611.2	+	8	2522	c.2159C>T	c.(2158-2160)tCc>tTc	p.S720F	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		CATGCCTACTCCATCCTGGAT	0.662000													16	63					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189855065	189855065	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189855065C>T	ENST00000304636.3	+	10	947	c.777C>T	c.(775-777)ttC>ttT	p.F259F	COL3A1_ENST00000317840.5_Silent_p.F259F	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	259	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TACCTGGATTCCCTGGTATGA	0.348000													15	30					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201190778	201190778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201190778G>A	ENST00000335211.4	+	19	10235	c.10105G>A	c.(10105-10107)Gga>Aga	p.G3369R	IGFN1_ENST00000295591.8_Missense_Mutation_p.G529R	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCTTCGGCCTGGAGAGGGCTA	0.607000													14	32					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33572868	33572868	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33572868G>A	ENST00000262873.7	+	11	959		c.e11-1			NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta							membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TCTGCCCACAGGGCAAGTTCA	0.662000													27	92					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553608	140553608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140553608G>A	ENST00000231137.3	+	1	1366	c.1192G>A	c.(1192-1194)Gaa>Aaa	p.E398K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		398	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.E398K(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCATCTGTCGAAAACTTCTA	0.493000													36	53					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122664263	122664263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:122664263C>T	ENST00000263461.6	+	25	3379	c.3133C>T	c.(3133-3135)Ccc>Tcc	p.P1045S	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	1045						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						CTCGTCAGGCCCCTCTCAGAG	0.443000													29	90					0	0	1	0	0
TRBV6-1	28606	broad.mit.edu	37	7	142028454	142028454	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142028454G>A	ENST00000390353.2	+	0	245																											ATGGGACTGAGGCTGATTTAT	0.498000													45	193					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189068185	189068185	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189068185G>A	ENST00000332517.3	+	6	1206	c.1066G>A	c.(1066-1068)Ggc>Agc	p.G356S	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	356	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GTGGGAAGTGGGCATCTGCAA	0.517000													16	68					0	0	1	0	0
GPR6	2830	broad.mit.edu	37	6	110301203	110301203	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110301203C>T	ENST00000414000.2	+	3	1172	c.933C>T	c.(931-933)gcC>gcT	p.A311A	GPR6_ENST00000275169.3_Silent_p.A296A			P46095	GPR6_HUMAN	G protein-coupled receptor 6	296						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		TGCCCTTCGCCATCTATTGCG	0.622000													5	46					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10563949	10563949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10563949G>A	ENST00000344979.3	+	1	335	c.10G>A	c.(10-12)Gtg>Atg	p.V4M	PDE4A_ENST00000592685.1_Intron|PDE4A_ENST00000440014.2_Intron|PDE4A_ENST00000352831.6_Intron|PDE4A_ENST00000380702.2_Intron|PDE4A_ENST00000293683.5_Intron	NM_006202.2	NP_006193.1	P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	0					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	GATGCCCTTGGTGGATTTCTT	0.652000													9	27					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63883944	63883944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63883944G>A	ENST00000246841.3	+	2	1248	c.205G>A	c.(205-207)Gac>Aac	p.D69N	MACROD1_ENST00000255681.6_Intron	NM_013280.4	NP_037412.2	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein 1	41					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|endometrium(3)|large_intestine(6)|lung(2)|prostate(1)|urinary_tract(1)	14						CTACTGCAACGACCGGGGACT	0.607000													23	44					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8476354	8476354	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8476354C>T	ENST00000447869.1	-	6	1641	c.723G>A	c.(721-723)ctG>ctA	p.L241L	STK33_ENST00000358872.3_Silent_p.L54L|STK33_ENST00000534493.1_Silent_p.L200L|STK33_ENST00000315204.1_Silent_p.L241L|STK33_ENST00000396673.1_Silent_p.L241L|STK33_ENST00000396672.1_Silent_p.L241L			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	241	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		TTATATTTTCCAGTTTCAGAT	0.259000													10	52					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211523399	211523399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211523399G>A	ENST00000233072.5	+	31	3939	c.3743G>A	c.(3742-3744)gGa>gAa	p.G1248E	CPS1_ENST00000451903.2_Missense_Mutation_p.G797E|CPS1_ENST00000430249.2_Missense_Mutation_p.G1254E	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1248	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTTGTCAAAGGAAATGATGTC	0.433000													7	62					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17543308	17543308	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17543308C>T	ENST00000229922.2	+	11	1675	c.1143C>T	c.(1141-1143)ctC>ctT	p.L381L	CAP2_ENST00000489374.1_Silent_p.L269L|CAP2_ENST00000493172.1_Silent_p.L121L|CAP2_ENST00000465994.1_Silent_p.L317L|CAP2_ENST00000378990.2_Silent_p.L355L	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	381	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			GTAAAAAACTCGGCCTGGTGT	0.403000													74	158					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125528104	125528104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:125528104C>T	ENST00000241305.3	-	9	1391	c.1237G>A	c.(1237-1239)Gag>Aag	p.E413K	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	413					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		ATCCGCGTCTCCTCCACCAGG	0.632000													42	79					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71740870	71740870	+	Silent	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:71740870G>C	ENST00000269500.5	-	10	1466	c.1131C>G	c.(1129-1131)ccC>ccG	p.P377P	FBXO15_ENST00000580806.1_5'UTR|FBXO15_ENST00000419743.2_Silent_p.P453P	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	377										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		AGCTGTCAGAGGGTGTGGCAG	0.522000													63	212					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172544728	172544728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:172544728C>T	ENST00000367723.3	+	11	1829	c.1705C>T	c.(1705-1707)Cct>Tct	p.P569S	SUCO_ENST00000263688.3_Missense_Mutation_p.P410S	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		ACAGAGTTTCCCTTTAGATGA	0.308000													6	62					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	76958702	76958702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76958702C>T	ENST00000257626.7	-	21	1759	c.1681G>A	c.(1681-1683)Gga>Aga	p.G561R	GSAP_ENST00000440473.1_Intron	NM_017439.3	NP_059135.2			gamma-secretase activating protein																		CTTCTTTTTCCTGTTTTCTAG	0.378000													15	40					0	0	1	0	0
ENGASE	64772	broad.mit.edu	37	17	77078205	77078205	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:77078205C>T	ENST00000539857.2	+	6	955	c.540C>T	c.(538-540)ttC>ttT	p.F180F	ENGASE_ENST00000579016.1_Intron|ENGASE_ENST00000584568.1_Intron			Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	0						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						GACCTCATTTCCTCATGGACC	0.607000													11	29					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81110977	81110977	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81110977G>A	ENST00000228644.3	+	1	287	c.135G>A	c.(133-135)gaG>gaA	p.E45E		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	45					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						ACAAAGCAGAGCTGCAGGGCT	0.622000													18	24					0	0	1	0	0
GSTA3	2940	broad.mit.edu	37	6	52761661	52761661	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52761661C>T	ENST00000211122.3	-	7	677	c.612G>A	c.(610-612)agG>agA	p.R204R	GSTA3_ENST00000370968.1_Silent_p.R154R	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	204	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	CGGGAGGCTTCCTTGGGCTGC	0.473000													29	111					0	0	1	0	0
ALDH7A1	501	broad.mit.edu	37	5	125919701	125919701	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:125919701G>A	ENST00000409134.3	-	4	535	c.316C>T	c.(316-318)Cct>Tct	p.P106S	ALDH7A1_ENST00000553117.1_Missense_Mutation_p.P106S|ALDH7A1_ENST00000413020.1_5'UTR|ALDH7A1_ENST00000447989.2_Missense_Mutation_p.P133S	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	106					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	TTTGGAGCAGGAATCTAAGAA	0.348000													29	50					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61982370	61982370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61982370C>T	ENST00000370263.4	-	5	614	c.393G>A	c.(391-393)ggG>ggA	p.G131G	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	131					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CCGCGAAGTCCCCGTCAGCAC	0.652000													6	35					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169825875	169825875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169825875C>T	ENST00000263817.6	-	16	2120	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	666	Interaction with HAX1 (By similarity).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ATGTCCTCTTCATTAAGAGCT	0.368000													11	26					0	0	1	0	0
CD69	969	broad.mit.edu	37	12	9907256	9907256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9907256C>T	ENST00000228434.3	-	4	498	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	CD69_ENST00000536709.1_Missense_Mutation_p.E140K	NM_001781.2	NP_001772.1	Q07108	CD69_HUMAN	CD69 molecule	140	C-type lectin.					integral to plasma membrane	sugar binding|transmembrane receptor activity			endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)	10						ACCCAGTGTTCCTCTCTACCT	0.393000													83	186					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064856	9064856	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9064856C>T	ENST00000397910.4	-	3	22793	c.22590G>A	c.(22588-22590)agG>agA	p.R7530R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7532	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACTGAATTTTCCTAGTGTTAG	0.473000													26	70					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21132126	21132126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21132126C>T	ENST00000261383.3	-	11	1633	c.1634G>A	c.(1633-1635)cGg>cAg	p.R545Q	DNAH3_ENST00000415178.1_Missense_Mutation_p.R545Q|CTC-508F8.1_ENST00000575612.1_RNA	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	545	Stem (By similarity).		R -> W (in dbSNP:rs16970910).		ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CACACATTGCCGATCAGCAGC	0.493000													11	27					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126398344	126398344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126398344G>A	ENST00000394329.3	+	13	12341	c.12328G>A	c.(12328-12330)Gga>Aga	p.G4110R	FAT4_ENST00000335110.5_Missense_Mutation_p.G2373R	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4110	Laminin G-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGTTACAGTTGGAGGTATCAG	0.353000													57	121					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166170230	166170230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166170230C>T	ENST00000375437.2	+	9	1425	c.1135C>T	c.(1135-1137)Cgt>Tgt	p.R379C	SCN2A_ENST00000375427.2_Missense_Mutation_p.R379C|SCN2A_ENST00000357398.3_Missense_Mutation_p.R379C|SCN2A_ENST00000283256.6_Missense_Mutation_p.R379C	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	379					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R379C(1)		NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTCCTTATTTCGTCTCATGAC	0.413000													27	99					0	0	1	0	0
MXRA8	54587	broad.mit.edu	37	1	1290115	1290115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1290115G>A	ENST00000309212.6	-	5	926	c.896C>T	c.(895-897)cCc>cTc	p.P299L	MXRA8_ENST00000445648.2_Missense_Mutation_p.P299L|MXRA8_ENST00000342753.4_Missense_Mutation_p.P198L	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	299						integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCCCCGGGGGGGCGGCTCCGC	0.731000													7	19					0	0	1	0	0
TIAL1	7073	broad.mit.edu	37	10	121337200	121337200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:121337200G>A	ENST00000369092.4	-	9	1544	c.236C>T	c.(235-237)cCa>cTa	p.P79L	TIAL1_ENST00000369093.2_Missense_Mutation_p.P219L|TIAL1_ENST00000436547.2_Missense_Mutation_p.P202L			Q01085	TIAR_HUMAN	TIA1 cytotoxic granule-associated RNA binding protein-like 1	202	RRM 1.				apoptosis|defense response|induction of apoptosis|regulation of transcription from RNA polymerase II promoter	lysosome|nucleus|stress granule	nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(3)|ovary(1)	13		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00239)|BRCA - Breast invasive adenocarcinoma(275;0.0932)		ACAATTTTTTGGACTTGACTG	0.368000													59	144					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87229775	87229775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87229775G>A	ENST00000297524.3	-	3	1206	c.1103C>T	c.(1102-1104)tCa>tTa	p.S368L	SLC7A13_ENST00000419776.2_Missense_Mutation_p.S359L	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	368						integral to membrane	amino acid transmembrane transporter activity	p.S368L(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						AGACCATAATGAACCCGTGAA	0.323000													13	56					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9307218	9307218	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9307218G>A	ENST00000261336.2	-	29	3796	c.3768C>T	c.(3766-3768)tcC>tcT	p.S1256S	PZP_ENST00000381997.2_Silent_p.S1042S	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TGACCTGGGTGGAGGAGAAAC	0.512000													9	19					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38318867	38318867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38318867C>T	ENST00000311856.4	+	10	1616	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S		NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	523						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		CTCTAGGTCCCCCAAATCAGT	0.542000													27	73					0	0	1	0	0
SENP1	29843	broad.mit.edu	37	12	48477508	48477508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48477508G>A	ENST00000004980.5	-	6	896	c.418C>T	c.(418-420)Cac>Tac	p.H140Y	SENP1_ENST00000549518.1_Missense_Mutation_p.H140Y|SENP1_ENST00000448372.1_Missense_Mutation_p.H140Y|SENP1_ENST00000339976.6_3'UTR|SENP1_ENST00000551330.1_Missense_Mutation_p.H140Y|SENP1_ENST00000549595.1_Missense_Mutation_p.H140Y|SENP1_ENST00000547886.1_5'UTR			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	140	Ser-rich.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				ACATGGCAGTGATGGTTTGAC	0.358000													32	70					0	0	1	0	0
SERTAD2	9792	broad.mit.edu	37	2	64863228	64863228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:64863228G>A	ENST00000313349.3	-	2	1075	c.778C>T	c.(778-780)Ccc>Tcc	p.P260S		NM_014755.2	NP_055570.1	Q14140	SRTD2_HUMAN	SERTA domain containing 2	260					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus				breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|skin(1)	12						GAAGTGCAGGGGTCAAAATCA	0.512000													22	53					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35801756	35801756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35801756C>T	ENST00000342694.2	+	8	1808	c.1553C>T	c.(1552-1554)tCg>tTg	p.S518L		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	518	Protein kinase.				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CTCACACTGTCGCTGGTGAGC	0.542000													19	95					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102959618	102959618	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102959618G>A	ENST00000311734.2	+	7	1144	c.805G>A	c.(805-807)Gag>Aag	p.E269K	IL1RL1_ENST00000404917.2_Missense_Mutation_p.E152K|IL1RL1_ENST00000233954.1_Missense_Mutation_p.E269K|IL1RL1_ENST00000409584.1_Missense_Mutation_p.E255K			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	269	Ig-like C2-type 3.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						AATTCAACAAGAGGAAGGGCA	0.418000													30	132					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47041196	47041196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:47041196C>T	ENST00000377604.3	+	15	2366	c.1624C>T	c.(1624-1626)Cct>Tct	p.P542S	RBM10_ENST00000329236.7_Missense_Mutation_p.P464S|RBM10_ENST00000345781.6_Missense_Mutation_p.P465S|RBM10_ENST00000468791.1_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	542					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						GCTCCAGAGCCCTACCCATCC	0.602000													3	23					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92346621	92346621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:92346621G>A	ENST00000276609.3	+	6	980	c.741G>A	c.(739-741)ctG>ctA	p.L247L	SLC26A7_ENST00000523719.1_Silent_p.L247L|SLC26A7_ENST00000309536.2_Silent_p.L247L	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	247						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TTAAAGAGCTGAATGAACAGT	0.338000													25	54					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25232061	25232061	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25232061G>A	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						GGAGTGGTAGGAGGAGGGTTG	0.463000													18	45					0	0	1	0	0
OTX2	5015	broad.mit.edu	37	14	57270922	57270922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:57270922G>A	ENST00000339475.5	-	4	533	c.257C>T	c.(256-258)cCc>cTc	p.P86L	OTX2_ENST00000408990.3_Missense_Mutation_p.P78L|OTX2_ENST00000554788.1_Intron|OTX2_ENST00000554559.1_Intron|OTX2_ENST00000555006.1_Missense_Mutation_p.P78L	NM_001270523.1|NM_001270524.1|NM_001270525.1|NM_021728.3	NP_001257452.1|NP_001257453.1|NP_001257454.1|NP_068374.1	P32243	OTX2_HUMAN	orthodenticle homeobox 2	78					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	19	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CCTCGACTCGGGCAAGTTGAT	0.567000													12	58					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066852	46066852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46066852C>T	ENST00000334670.8	+	1	522	c.477C>T	c.(475-477)tcC>tcT	p.S159S	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	153	25 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						GCTGTGTGTCCACCTGCTCTG	0.637000													57	225					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62329911	62329911	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62329911G>A	ENST00000371158.2	+	20	2555	c.2439_splice	c.e20-1	p.G814_splice	INADL_ENST00000316485.6_Splice_Site_p.G814_splice	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	814					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TATTTATAGGGATTTAGAGAT	0.358000													11	71					0	0	1	0	0
SLC35F2	54733	broad.mit.edu	37	11	107673741	107673741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:107673741G>A	ENST00000525071.1	-	10	1513	c.925C>T	c.(925-927)Ctg>Ttg	p.L309L	SLC35F2_ENST00000375682.4_Silent_p.L262L|SLC35F2_ENST00000525815.1_Silent_p.L309L|SLC35F2_ENST00000265836.7_Silent_p.L161L|SLC35F2_ENST00000429869.1_Silent_p.L309L			Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	309					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		TAGCCAAACAGAAAGAGTCCA	0.413000													22	58					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68903887	68903887	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:68903887G>A	ENST00000262340.5	-	10	1164	c.1111C>T	c.(1111-1113)Cct>Tct	p.P371S		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	371					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						ATATTCAAAGGAAGTACATAT	0.373000													20	45					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202010	140202010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140202010G>A	ENST00000529859.1	+	1	650	c.650G>A	c.(649-651)gGa>gAa	p.G217E	PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.G217E|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.G217E	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGATGGAGGAAAACCCGAA	0.358000													46	125					0	0	1	0	0
RASA4	10156	broad.mit.edu	37	7	102246372	102246372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:102246372G>A	ENST00000262940.7	-	5	428	c.361C>T	c.(361-363)Cac>Tac	p.H121Y	RASA4_ENST00000449970.2_Missense_Mutation_p.H121Y|RP11-514P8.6_ENST00000519541.1_3'UTR|RASA4_ENST00000462172.1_Missense_Mutation_p.H49Y|RASA4_ENST00000461209.1_Missense_Mutation_p.H49Y	NM_006989.5	NP_008920.5	O43374	RASL2_HUMAN	RAS p21 protein activator 4	121					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytosol|intrinsic to internal side of plasma membrane	metal ion binding|Ras GTPase activator activity			lung(1)|prostate(1)|urinary_tract(1)	3						AGCCGCAGGTGGATCTCGCCC	0.716000													12	24					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332600	71332600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71332600C>T	ENST00000242462.4	-	2	229	c.200G>A	c.(199-201)gGa>gAa	p.G67E		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	67					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						CCGGCTGCGTCCCCCGCGCCG	0.697000													4	9					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215807904	215807904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215807904C>T	ENST00000366943.2	-	70	15580	c.15194G>A	c.(15193-15195)aGa>aAa	p.R5065K	USH2A_ENST00000307340.3_Missense_Mutation_p.R5065K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	5065					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGGATTTTTCTTTGTAGTAT	0.448000										HNSCC(13;0.011)			24	75					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51220090	51220090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51220090G>A	ENST00000293441.1	-	1	105	c.87C>T	c.(85-87)tcC>tcT	p.S29S	SHANK1_ENST00000359082.3_Silent_p.S29S|SHANK1_ENST00000391814.1_Silent_p.S29S	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	29					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCCCGTCTGGGGAGCTGTCGG	0.711000													10	6					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51649346	51649346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51649346C>T	ENST00000317643.6	+	4	1064	c.995C>T	c.(994-996)tCc>tTc	p.S332F	SIGLEC7_ENST00000305628.7_Missense_Mutation_p.S239F|SIGLEC7_ENST00000600577.1_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	332	Ig-like C2-type 2.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CAGCACGTTTCCCTGAACCTC	0.607000													25	61					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6013256	6013256	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:6013256G>A	ENST00000259569.5	-	1	2362	c.2352C>T	c.(2350-2352)tcC>tcT	p.S784S		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	784					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TAACTTCAATGGACTTTGCAA	0.388000													66	81					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57754021	57754021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57754021G>A	ENST00000281282.5	+	8	2412	c.2334G>A	c.(2332-2334)atG>atA	p.M778I		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	778						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		ATCAGGAGATGGACAAGCTGA	0.537000													26	69					0	0	1	0	0
TRAV9-2	28677	broad.mit.edu	37	14	22409569	22409569	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22409569G>A	ENST00000390441.2	+	0	115																											AGAACCCGTGGAAATTCAGTG	0.448000													4	9					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130283963	130283963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130283963G>A	ENST00000358511.6	+	3	818	c.787G>A	c.(787-789)Gaa>Aaa	p.E263K	COL6A6_ENST00000453409.2_Missense_Mutation_p.E263K	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	263	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TGACATAAAGGAAAATTGCAT	0.393000													35	128					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64397937	64397937	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64397937G>A	ENST00000265459.6	-	19	4155	c.3694C>T	c.(3694-3696)Cga>Tga	p.R1232*	NRXN2_ENST00000377559.3_Nonsense_Mutation_p.R1192*|NRXN2_ENST00000409571.1_Nonsense_Mutation_p.R1225*|NRXN2_ENST00000377551.1_Nonsense_Mutation_p.R1232*|NRXN2_ENST00000301894.2_Nonsense_Mutation_p.R186*	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1232	Laminin G-like 6.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CCGCCGCTTCGAGTGAAGCGC	0.672000													27	84					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157497642	157497642	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157497642G>A	ENST00000361835.3	-	9	1882	c.1725C>T	c.(1723-1725)gcC>gcT	p.A575A	FCRL5_ENST00000356953.4_Silent_p.A575A|FCRL5_ENST00000368190.3_Silent_p.A575A|FCRL5_ENST00000368191.3_Silent_p.A490A	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	575	Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CCACAGCCTGGGCCCTGGGAA	0.532000													33	106					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158974352	158974352	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158974352C>T	ENST00000605860.1	+	7	573	c.527C>T	c.(526-528)cCc>cTc	p.P176L	UPP2_ENST00000409859.4_Missense_Mutation_p.P176L|UPP2_ENST00000005756.4_Missense_Mutation_p.P119L|UPP2_ENST00000460456.1_Intron			O95045	UPP2_HUMAN	uridine phosphorylase 2	119					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						ATGGGCATCCCCTCCATTTCT	0.408000													12	102					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38862636	38862636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38862636G>A	ENST00000359357.3	+	57	8346	c.8092G>A	c.(8092-8094)Gac>Aac	p.D2698N	DNAH8_ENST00000449981.2_Missense_Mutation_p.D2915N|DNAH8_ENST00000441566.1_Missense_Mutation_p.D2662N					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGTAATTGCAGACAGGTGCGT	0.398000													11	16					0	0	1	0	0
ODF1	4956	broad.mit.edu	37	8	103564043	103564043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:103564043G>A	ENST00000285402.3	+	1	244	c.88G>A	c.(88-90)Gaa>Aaa	p.E30K		NM_024410.3	NP_077721.2	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	30					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			ATGCATCGACGAATTTAGCAC	0.493000													53	143					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22255652	22255652	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22255652G>A	ENST00000594947.1	+	2	189	c.45G>A	c.(43-45)ctG>ctA	p.L15L	ZNF257_ENST00000600162.1_Silent_p.L15L	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	15	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				AATTCTCTCTGGAGGAGTGGC	0.433000													50	160					0	0	1	0	0
YTHDC2	64848	broad.mit.edu	37	5	112929053	112929053	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:112929053C>A	ENST00000161863.4	+	29	4479	c.4266C>A	c.(4264-4266)ccC>ccA	p.P1422P		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1422							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AACGTCTTCCCTTGGGAGAAA	0.368000													24	64					4.7796e-09	4.79738e-09	1	1	0
CAPN9	10753	broad.mit.edu	37	1	230916261	230916261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230916261G>A	ENST00000354537.1	+	10	1292	c.1210G>A	c.(1210-1212)Gaa>Aaa	p.E404K	CAPN9_ENST00000366666.2_Missense_Mutation_p.E367K|CAPN9_ENST00000271971.2_Missense_Mutation_p.E430K|RP11-99J16__A.2_ENST00000452640.1_RNA|RP11-99J16__A.2_ENST00000412344.1_RNA|RP11-99J16__A.2_ENST00000428480.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	430	Domain III.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TGACAAAGACGAACACCTGAA	0.517000													32	83					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40300277	40300277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40300277C>T	ENST00000263791.5	+	25	3500	c.3457C>T	c.(3457-3459)Ccc>Tcc	p.P1153S	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.P1125S|EIF2AK4_ENST00000559311.1_3'UTR	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1153	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCGATTTCATCCCAAAGAACT	0.408000													54	185					0	0	1	0	0
RERG	85004	broad.mit.edu	37	12	15262412	15262412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15262412C>T	ENST00000256953.2	-	5	568	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	RERG_ENST00000546331.1_Missense_Mutation_p.E59K|RERG_ENST00000538313.1_Missense_Mutation_p.E78K|RERG_ENST00000536465.1_Missense_Mutation_p.E78K	NM_032918.2	NP_116307.1	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	78					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16						ACAAAGCCTTCCCCCCATCGC	0.458000													51	464					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52502448	52502448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:52502448C>T	ENST00000219746.9	-	2	410	c.126G>A	c.(124-126)gcG>gcA	p.A42A	TOX3_ENST00000407228.3_Silent_p.A38A	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	42					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						ACGCATTGTTCGCCTCAGCCA	0.353000													26	98					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69959346	69959346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:69959346C>T	ENST00000359154.2	+	11	1294	c.1193C>T	c.(1192-1194)tCg>tTg	p.S398L	WWP2_ENST00000356003.2_Missense_Mutation_p.S398L|WWP2_ENST00000542271.1_Missense_Mutation_p.S282L|WWP2_ENST00000568684.1_5'UTR|WWP2_ENST00000544162.1_3'UTR|WWP2_ENST00000448661.1_Missense_Mutation_p.S398L	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2	398					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity	p.S398L(1)		breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCGAGTGCTTCGACTGACCAT	0.488000													182	397					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38627445	38627445	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38627445G>A	ENST00000413689.1	-	16	2717	c.2524C>T	c.(2524-2526)Ctg>Ttg	p.L842L	SCN5A_ENST00000423572.2_Silent_p.L842L|SCN5A_ENST00000425664.1_Silent_p.L842L|SCN5A_ENST00000455624.2_Silent_p.L842L|SCN5A_ENST00000450102.2_Silent_p.L842L|SCN5A_ENST00000449557.2_Silent_p.L842L|SCN5A_ENST00000414099.2_Silent_p.L842L|SCN5A_ENST00000451551.2_Silent_p.L842L|SCN5A_ENST00000333535.4_Silent_p.L842L|SCN5A_ENST00000443581.1_Silent_p.L842L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	842					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACCAGTGTCAGGTTCCCCAGT	0.572000													30	63					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70303932	70303932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70303932G>A	ENST00000310961.5	+	8	932	c.514G>A	c.(514-516)Gag>Aag	p.E172K	LRRC7_ENST00000370958.1_Missense_Mutation_p.E205K|LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.E167K			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	167						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GCGGATCTTGGAGTTAAGAGA	0.289000													8	45					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13397765	13397765	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13397765G>T	ENST00000360228.5	-	20	3104	c.3105C>A	c.(3103-3105)tcC>tcA	p.S1035S	CACNA1A_ENST00000573710.2_Silent_p.S1036S	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1036					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CAGGGACCCCGGAGCCCTGGT	0.537000													18	16					2.94398e-08	2.95381e-08	1	1	0
C16orf62	57020	broad.mit.edu	37	16	19580865	19580865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19580865C>T	ENST00000438132.3	+	3	552	c.504C>T	c.(502-504)ctC>ctT	p.L168L	C16orf62_ENST00000417362.2_Silent_p.L79L|C16orf62_ENST00000542263.1_Silent_p.L168L|C16orf62_ENST00000251143.5_Silent_p.L79L|C16orf62_ENST00000538853.1_Silent_p.L168L	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	79				F -> S (in Ref. 3; CAH10399).		integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						CTGACCCCCTCTCCATGTTTG	0.612000													7	50					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77406534	77406534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77406534G>A	ENST00000560626.2	-	7	5680	c.5205C>T	c.(5203-5205)tcC>tcT	p.S1735S	PEAK1_ENST00000312493.4_Silent_p.S1735S			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1735					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TACAACTGAGGGAGTCTGTAG	0.463000													28	127					0	0	1	0	0
EGR2	1959	broad.mit.edu	37	10	64573977	64573977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:64573977G>A	ENST00000242480.3	-	2	746	c.421C>T	c.(421-423)Ccc>Tcc	p.P141S	EGR2_ENST00000411732.1_Missense_Mutation_p.P91S|EGR2_ENST00000439032.1_Missense_Mutation_p.P141S	NM_000399.3|NM_001136177.1	NP_000390.2|NP_001129649.1	P11161	EGR2_HUMAN	early growth response 2	141					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	36	Prostate(12;0.0297)|all_hematologic(501;0.228)					AGTGGGTTGGGGGAGGCAGAG	0.597000													15	61					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121384967	121384967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121384967C>T	ENST00000260197.7	+	8	1277	c.1148C>T	c.(1147-1149)tCc>tTc	p.S383F	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	383					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CTGAAGTTCTCCCTGTCCTTG	0.542000													19	62					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154681001	154681001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:154681001G>A	ENST00000404039.1	+	24	2719	c.2132G>A	c.(2131-2133)cGa>cAa	p.R711Q	DPP6_ENST00000332007.3_Missense_Mutation_p.R713Q|DPP6_ENST00000427557.1_Missense_Mutation_p.R668Q|DPP6_ENST00000377770.3_Missense_Mutation_p.R775Q	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	775					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GTAGCCCATCGAGTCTCCGCG	0.542000													9	31					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19592859	19592859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19592859G>A	ENST00000438132.3	+	7	838	c.790G>A	c.(790-792)Gag>Aag	p.E264K	C16orf62_ENST00000417362.2_Missense_Mutation_p.E175K|C16orf62_ENST00000542263.1_Missense_Mutation_p.E264K|C16orf62_ENST00000251143.5_Missense_Mutation_p.E175K|C16orf62_ENST00000543152.1_5'UTR|C16orf62_ENST00000448695.1_Missense_Mutation_p.E53K|C16orf62_ENST00000538853.1_3'UTR	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	175						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						TTCCCAAAAGGAGCTGTTGAA	0.493000													39	157					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19428056	19428056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19428056G>A	ENST00000375267.2	-	88	12984	c.12981C>T	c.(12979-12981)acC>acT	p.T4327T	UBR4_ENST00000375224.1_Silent_p.T34T|UBR4_ENST00000543981.1_Silent_p.T18T|UBR4_ENST00000375226.2_Silent_p.T4303T|UBR4_ENST00000375254.3_Silent_p.T4327T|UBR4_ENST00000375217.2_Silent_p.T4320T			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	4327					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGAACACCGGGGTCCGGTAGT	0.537000													27	120					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12186665	12186665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12186665G>A	ENST00000439326.3	+	4	905	c.730G>A	c.(730-732)Gaa>Aaa	p.E244K	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	244					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TCAAATACATGAAAGAACTCA	0.373000													9	35					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98850360	98850360	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:98850360G>A	ENST00000554295.1	-	0	563					NR_033801.1																						CCTATGGGTCGAATGTTACCT	0.413000													8	22					0	0	1	0	0
TM4SF18	116441	broad.mit.edu	37	3	149040164	149040164	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:149040164C>T	ENST00000296059.2	-	5	735	c.470G>A	c.(469-471)tGg>tAg	p.W157*	TM4SF18_ENST00000470080.1_Nonsense_Mutation_p.W157*|RP11-206M11.7_ENST00000489011.1_RNA	NM_138786.3	NP_620141.1	Q96CE8	T4S18_HUMAN	transmembrane 4 L six family member 18	157						integral to membrane				lung(1)|ovary(1)|prostate(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			AATGATGTTCCACTCCACAAC	0.443000													8	82					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95500992	95500992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95500992C>T	ENST00000297591.5	-	24	5456	c.5381G>A	c.(5380-5382)gGa>gAa	p.G1794E	KIAA1429_ENST00000437199.1_3'UTR	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1794					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AACAAACTTTCCTCTTGAGCC	0.498000													67	174					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519592	113519592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113519592C>T	ENST00000284601.3	-	4	1623	c.1555G>A	c.(1555-1557)Gaa>Aaa	p.E519K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	519					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						ATTCTTTGTTCTTCATCATCC	0.333000													9	31					0	0	1	0	0
DEFA6	1671	broad.mit.edu	37	8	6783476	6783476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:6783476G>A	ENST00000297436.2	-	1	122	c.82C>T	c.(82-84)Cca>Tca	p.P28S		NM_001926.3	NP_001917.1	Q01524	DEF6_HUMAN	defensin, alpha 6, Paneth cell-specific	28					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				lung(4)	4			STAD - Stomach adenocarcinoma(24;0.0322)	COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		GCCTGCAGTGGATCATCCTCA	0.577000													10	19					0	0	1	0	0
PNKP	11284	broad.mit.edu	37	19	50370385	50370385	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50370385G>A	ENST00000322344.3	-	2	186	c.77C>T	c.(76-78)tCg>tTg	p.S26L	PNKP_ENST00000600573.1_Missense_Mutation_p.S26L|PNKP_ENST00000595792.1_5'UTR|PNKP_ENST00000596014.1_Missense_Mutation_p.S26L|PNKP_ENST00000600910.1_Missense_Mutation_p.S26L	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	26					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		TTGCCCGTCCGAGGGCAGGAA	0.726000								Other BER factors					13	51					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23019757	23019757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23019757C>T	ENST00000327968.5	+	1	1671	c.1583C>T	c.(1582-1584)tCc>tTc	p.S528F	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	528	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						GATATAGTATCCCGAGGTCTT	0.378000													44	35					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42434764	42434764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42434764G>A	ENST00000397272.3	-	19	2388	c.2297C>T	c.(2296-2298)cCc>cTc	p.P766L	PLA2G4F_ENST00000382396.4_Missense_Mutation_p.P764L	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	764	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GTTAACCAGGGGGAAGTGCAG	0.632000													19	50					0	0	1	0	0
PAX7	5081	broad.mit.edu	37	1	19018374	19018374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19018374G>A	ENST00000420770.2	+	5	796	c.713G>A	c.(712-714)aGg>aAg	p.R238K	PAX7_ENST00000400661.3_Missense_Mutation_p.R236K|PAX7_ENST00000375375.3_Missense_Mutation_p.R238K	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	238					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		GCCTTTGAGAGGACCCACTAC	0.637000			T	FOXO1A	alveolar rhabdomyosarcoma								7	24					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139216801	139216801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139216801G>A	ENST00000274710.3	+	11	1848	c.1643G>A	c.(1642-1644)gGg>gAg	p.G548E		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	548	PH.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCTCAAAGGGACCATCCTG	0.622000													34	66					0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31256287	31256287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:31256287C>T	ENST00000407793.2	+	25	2740	c.2489C>T	c.(2488-2490)tCt>tTt	p.S830F	DDX11_ENST00000542838.1_Silent_p.L832L|DDX11_ENST00000350437.4_Silent_p.L782L|DDX11_ENST00000228264.6_Silent_p.L806L|DDX11_ENST00000545668.1_Missense_Mutation_p.S830F|DDX11_ENST00000251758.5_3'UTR	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	830					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					AGGGAAGGCTCTGGTGGAGAA	0.637000										Multiple Myeloma(12;0.14)			8	18					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62286062	62286062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62286062G>A	ENST00000378024.4	-	5	16101	c.15827C>T	c.(15826-15828)cCc>cTc	p.P5276L	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5276					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AGAAACATCGGGCCCTTCGAG	0.532000													20	69					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237936946	237936946	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237936946C>T	ENST00000366574.2	+	87	12090	c.11773C>T	c.(11773-11775)Cag>Tag	p.Q3925*	RYR2_ENST00000360064.6_Nonsense_Mutation_p.Q3931*|RYR2_ENST00000542537.1_Nonsense_Mutation_p.Q3909*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3925					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGAGTATATTCAGGTAAACAT	0.368000													12	24					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77387698	77387698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77387698C>T	ENST00000282849.5	-	10	1964	c.1546G>A	c.(1546-1548)Gat>Aat	p.D516N		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	516	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GTGTCAGCATCATAAATCTGT	0.428000													45	121					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756444	94756444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94756444C>T	ENST00000554723.1	-	2	1025	c.607G>A	c.(607-609)Ggg>Agg	p.G203R	SERPINA10_ENST00000261994.4_Missense_Mutation_p.G163R|SERPINA10_ENST00000554173.1_Missense_Mutation_p.G163R|SERPINA10_ENST00000393096.1_Missense_Mutation_p.G163R			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	163					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		GCAAAACTCCCCTGTGTGAGG	0.507000													34	82					0	0	1	0	0
KLK7	5650	broad.mit.edu	37	19	51485632	51485632	+	Silent	SNP	G	G	A	rs113100315		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51485632G>A	ENST00000391807.1	-	2	125	c.24C>T	c.(22-24)ccC>ccT	p.P8P	KLK7_ENST00000597707.1_Intron|KLK7_ENST00000595638.1_5'UTR|CTB-147C22.9_ENST00000594512.1_RNA|KLK7_ENST00000595820.1_Silent_p.P8P|KLK7_ENST00000336317.4_5'UTR	NM_139277.2	NP_644806.1	P49862	KLK7_HUMAN	kallikrein-related peptidase 7	8					epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(2)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		AGATCTGCAGGGGCAGGAGAA	0.592000													4	9					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96937826	96937826	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96937826G>A	ENST00000267584.4	+	13	1413	c.1369G>A	c.(1369-1371)Gat>Aat	p.D457N		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	457	Adenylate kinase.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TCAACTAGACGATCAATATAT	0.279000													10	62					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4525711	4525711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4525711C>T	ENST00000381848.3	-	6	734	c.654G>A	c.(652-654)ggG>ggA	p.G218G		NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	218						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						GCCTCAGTTTCCCCACAGAGT	0.662000													34	68					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325004	150325004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150325004C>T	ENST00000328902.5	-	3	898	c.682G>A	c.(682-684)Gga>Aga	p.G228R	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	228							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TAATAATCTCCTTCGTTTTCC	0.512000													70	176					0	0	1	0	0
OXGR1	27199	broad.mit.edu	37	13	97639219	97639219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:97639219G>A	ENST00000298440.1	-	4	1038	c.795C>T	c.(793-795)atC>atT	p.I265I	OXGR1_ENST00000543457.1_Silent_p.I265I	NM_080818.3	NP_543008.3	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	265						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			NS(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			GGCGAGATTCGATCCGAATGA	0.433000													20	69					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10392112	10392112	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10392112G>A	ENST00000397077.1	-	14	2726	c.2151C>T	c.(2149-2151)ttC>ttT	p.F717F	ATP2B2_ENST00000352432.4_Silent_p.F762F|ATP2B2_ENST00000343816.4_Silent_p.F748F|ATP2B2_ENST00000383800.4_Silent_p.F717F|ATP2B2_ENST00000360273.2_Silent_p.F762F			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	762					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						TCCTCCTGTTGAACTCCTTGC	0.592000													32	55					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101551177	101551177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101551177C>T	ENST00000536262.2	-	15	2271	c.1713G>A	c.(1711-1713)aaG>aaA	p.K571K		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	571	Poly-Lys.				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AAACATGCTTCTTCTAAAAGA	0.343000													3	11					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109271289	109271289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109271289G>A	ENST00000370017.3	+	8	1682	c.1405G>A	c.(1405-1407)Gat>Aat	p.D469N	FNDC7_ENST00000271311.2_Missense_Mutation_p.D470N	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	470	Fibronectin type-III 6.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TGTTTCAAGGGATGCATTCTC	0.418000													20	53					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70342950	70342950	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70342950C>T	ENST00000333646.6	+	11	1690	c.1491C>T	c.(1489-1491)tcC>tcT	p.S497S	MED12_ENST00000374102.1_Silent_p.S497S|MED12_ENST00000374080.3_Silent_p.S497S	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	497					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					TCCAGATCTCCTCAGATGATG	0.483000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						82	64					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3654979	3654979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3654979C>T	ENST00000263087.4	-	15	1956	c.1858G>A	c.(1858-1860)Gga>Aga	p.G620R		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	620					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TCCCAGTGTCCATTGTAGATA	0.597000													18	33					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141291460	141291460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:141291460G>A	ENST00000247452.3	-	3	661	c.314C>T	c.(313-315)tCc>tTc	p.S105F		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	105	Ser-rich.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					TGAAAAAGAGGAGCAGCAGGA	0.557000										HNSCC(46;0.14)			26	26					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71068757	71068757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:71068757G>A	ENST00000452400.2	-	11	2024	c.1843C>T	c.(1843-1845)Ccc>Tcc	p.P615S	NCOA2_ENST00000524223.1_5'UTR	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	615					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GGCAGGTTGGGGTCATTTGTT	0.552000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								26	94					0	0	1	0	0
DTX3	196403	broad.mit.edu	37	12	58000757	58000757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58000757G>A	ENST00000548198.1	+	3	1615	c.111G>A	c.(109-111)ctG>ctA	p.L37L	DTX3_ENST00000337737.3_Silent_p.L37L|DTX3_ENST00000548804.1_Silent_p.L37L|DTX3_ENST00000551632.1_Silent_p.L40L			Q8N9I9	DTX3_HUMAN	deltex homolog 3 (Drosophila)	37					Notch signaling pathway	cytoplasm	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)|urinary_tract(1)	12	Melanoma(17;0.122)					CAGCCCGGCTGGCCCGGCTTC	0.607000													47	330					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62192276	62192276	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62192276G>A	ENST00000467148.1	-	15	7222	c.7153C>T	c.(7153-7155)Ctt>Ttt	p.L2385F	HELZ2_ENST00000427522.2_Missense_Mutation_p.L1816F	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		TCTCCGAGAAGAACCACCTGG	0.642000													17	99					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	598008	598008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:598008C>T	ENST00000219611.2	+	4	1533	c.1170C>T	c.(1168-1170)agC>agT	p.S390S	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		ACAAGCCCAGCCCCTGCGGCA	0.746000													3	8					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203667416	203667416	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203667416C>T	ENST00000357681.5	+	3	1448	c.325C>T	c.(325-327)Ctg>Ttg	p.L109L	ATP2B4_ENST00000391954.2_Silent_p.L109L|ATP2B4_ENST00000367218.3_Silent_p.L109L|ATP2B4_ENST00000341360.2_Silent_p.L109L|ATP2B4_ENST00000367219.3_Silent_p.L109L	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	109					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GCTTATCATCCTGGAGATTGC	0.483000													32	104					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45968358	45968358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45968358G>A	ENST00000260324.7	+	6	1100	c.714G>A	c.(712-714)ggG>ggA	p.G238G	RP11-96O20.4_ENST00000564080.1_Silent_p.G238G|SQRDL_ENST00000568606.1_Silent_p.G238G	NM_021199.2	NP_067022.1	Q9Y6N5	SQRD_HUMAN	sulfide quinone reductase-like (yeast)	238							oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	11		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		CCATTTTCGGGGTTAAGAAGT	0.443000													95	191					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42489109	42489109	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42489109G>A	ENST00000545399.1	-	8	1146	c.993C>T	c.(991-993)atC>atT	p.I331I	ATP1A3_ENST00000602133.1_Silent_p.I288I|ATP1A3_ENST00000543770.1_Silent_p.I329I|ATP1A3_ENST00000302102.5_Silent_p.I318I	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	318					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CATTGGCCACGATGATGCCGA	0.612000													8	26					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	410451	410451	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:410451G>A	ENST00000280886.6	-	20	2427	c.2340C>T	c.(2338-2340)ttC>ttT	p.F780F	DIP2C_ENST00000381496.3_3'UTR|DIP2C_ENST00000540204.1_Silent_p.F101F	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	780						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CGGGACCCACGAACCCCAGCA	0.617000													19	65					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103067330	103067330	+	Silent	SNP	C	C	T	rs140183707	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103067330C>T	ENST00000264260.2	+	11	1822	c.1233C>T	c.(1231-1233)ttC>ttT	p.F411F	IL18RAP_ENST00000409369.1_Silent_p.F269F	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	411	TIR.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity	p.F411F(1)		autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TTGATGCTTTCGTATCCTATG	0.343000													36	78					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663768	169663768	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169663768C>T	ENST00000483289.2	-	0	3526				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						TGGCCAGATTCACAGAGCATT	0.498000													12	152					0	0	1	0	0
OPHN1	4983	broad.mit.edu	37	X	67502952	67502952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:67502952G>A	ENST00000355520.5	-	4	899	c.258C>T	c.(256-258)tcC>tcT	p.S86S	OPHN1_ENST00000540071.1_Silent_p.S86S	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	86					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						ATTCCTTGAAGGATTCAGCTG	0.413000													17	21					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56380414	56380414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56380414G>A	ENST00000370754.5	-	72	18316	c.18317C>T	c.(18316-18318)tCa>tTa	p.S6106L	DST_ENST00000361203.3_Missense_Mutation_p.S5817L|DST_ENST00000312431.6_3'UTR|DST_ENST00000446842.2_Missense_Mutation_p.S5602L|DST_ENST00000370769.4_Missense_Mutation_p.S5928L|DST_ENST00000370788.2_Missense_Mutation_p.S3731L|DST_ENST00000421834.2_Missense_Mutation_p.S3840L|DST_ENST00000340834.4_5'UTR|DST_ENST00000244364.6_Missense_Mutation_p.S3514L			Q03001	DYST_HUMAN	dystonin	5926					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATACCTTTCTGAATTAATCTG	0.418000													5	35					0	0	1	0	0
FRRS1L	23732	broad.mit.edu	37	9	111911944	111911944	+	Missense_Mutation	SNP	C	C	T	rs141125474	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111911944C>T	ENST00000374581.3	-	2	447	c.448G>A	c.(448-450)Gac>Aac	p.D150N		NM_014334.2	NP_055149.2	Q9P0K9	CI004_HUMAN	ferric-chelate reductase 1-like	150						integral to membrane											TTTCCACAGTCGTCCACTTTG	0.428000													4	38					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159646591	159646591	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159646591G>A	ENST00000297267.9	+	8	1109	c.909G>A	c.(907-909)gaG>gaA	p.E303E	FNDC1_ENST00000340366.6_Silent_p.E303E|FNDC1_ENST00000480856.1_3'UTR	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	303	Fibronectin type-III 3.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCTATCGAGAGAAGGGGGAAT	0.468000													58	91					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63533730	63533730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:63533730G>A	ENST00000307078.5	-	6	1737	c.1424C>T	c.(1423-1425)tCg>tTg	p.S475L	AXIN2_ENST00000375702.5_Missense_Mutation_p.S475L	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	475	Interaction with beta-catenin (By similarity).				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						GTGGTACTGCGAATGGTGGTG	0.711000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				3	12					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49957827	49957827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:49957827C>T	ENST00000376056.2	-	5	1660	c.1510G>A	c.(1510-1512)Gga>Aga	p.G504R	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Intron|AKAP4_ENST00000358526.2_Missense_Mutation_p.G513R|AKAP4_ENST00000376064.3_Missense_Mutation_p.G504R			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	513					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					CATGAGTTTCCTTGCTTTTGG	0.448000													86	53					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152084126	152084126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152084126C>T	ENST00000368804.1	-	2	1566	c.1567G>A	c.(1567-1569)Gag>Aag	p.E523K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	523	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTCCTCCTCCTGGCGCTTC	0.652000													44	196					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079149	57079149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57079149G>A	ENST00000316981.3	-	5	1635	c.1156C>T	c.(1156-1158)Cct>Tct	p.P386S	PLAG1_ENST00000429357.2_Missense_Mutation_p.P386S|PLAG1_ENST00000423799.2_Missense_Mutation_p.P304S	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	386	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Massively activates transcription.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			CCAATCTGAGGATCCAACCCT	0.483000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								36	110					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184938	19184938	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:19184938G>A	ENST00000275461.3	-	1	106	c.48C>T	c.(46-48)ttC>ttT	p.F16F	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	16					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						GGTCTGCGACGAAGTCCAGCA	0.672000													17	47					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72993646	72993646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72993646G>A	ENST00000268489.5	-	2	1071	c.399C>T	c.(397-399)atC>atT	p.I133I	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	133					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GCTGGTAGACGATCTCCCCGG	0.711000													17	47					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1221818	1221818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1221818G>A	ENST00000304460.10	+	12	1760	c.1704G>A	c.(1702-1704)gaG>gaA	p.E568E		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	568					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTCCCCAGGAGGAATTTCCCA	0.592000													13	49					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95502186	95502186	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95502186G>A	ENST00000343958.4	-	11	3425	c.3202C>T	c.(3202-3204)Cag>Tag	p.Q1068*	FGD6_ENST00000549499.1_Nonsense_Mutation_p.Q1068*|FGD6_ENST00000546711.1_Nonsense_Mutation_p.Q1068*	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1068					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						ATAAGTTTCTGAAAGTTGTCC	0.423000													11	45					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142565412	142565412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142565412C>T	ENST00000392957.2	+	12	2584	c.1797C>T	c.(1795-1797)tcC>tcT	p.S599S	EPHB6_ENST00000442129.1_Silent_p.S599S|EPHB6_ENST00000411471.2_Silent_p.S322S	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	599						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					TGATCGGCTCCATCCTGGGGG	0.657000													8	14					0	0	1	0	0
CHRM1	1128	broad.mit.edu	37	11	62677322	62677322	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62677322G>A	ENST00000306960.3	-	2	1792	c.1251C>T	c.(1249-1251)tgC>tgT	p.C417C	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	417					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	AGAGTGCGTAGCACATGGGGT	0.607000													37	146					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154860085	154860085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:154860085G>A	ENST00000460393.1	+	12	1274	c.1154G>A	c.(1153-1155)cGa>cAa	p.R385Q	MME_ENST00000360490.2_Missense_Mutation_p.R385Q|MME_ENST00000462745.1_Missense_Mutation_p.R385Q|MME_ENST00000492661.1_Missense_Mutation_p.R385Q|MME_ENST00000493237.1_Missense_Mutation_p.R385Q	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	385					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding	p.R385Q(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	AGCCTCAGCCGAACCTACAAG	0.383000													11	108					0	0	1	0	0
KIAA0391	9692	broad.mit.edu	37	14	35649969	35649969	+	Missense_Mutation	SNP	C	C	T	rs147065101		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:35649969C>T	ENST00000557565.1	+	5	1642	c.1261C>T	c.(1261-1263)Cgt>Tgt	p.R421C	KIAA0391_ENST00000604948.1_Missense_Mutation_p.R326C|KIAA0391_ENST00000603544.1_Missense_Mutation_p.R405C|KIAA0391_ENST00000250377.7_Missense_Mutation_p.R326C|KIAA0391_ENST00000605870.1_Missense_Mutation_p.R49C|KIAA0391_ENST00000321130.10_Missense_Mutation_p.R405C|KIAA0391_ENST00000534898.4_Missense_Mutation_p.R421C			O15091	MRRP3_HUMAN	KIAA0391	421					tRNA processing	mitochondrion				central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		TCCTAAAGTTCGTGAATCTCA	0.333000													13	54					0	0	1	0	0
HDAC6	10013	broad.mit.edu	37	X	48666444	48666444	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48666444C>A	ENST00000334136.5	+	9	815	c.637C>A	c.(637-639)Cct>Act	p.P213T	HDAC6_ENST00000444343.2_Missense_Mutation_p.P227T|HDAC6_ENST00000469223.1_3'UTR|HDAC6_ENST00000413163.2_Missense_Mutation_p.P158T|HDAC6_ENST00000376619.2_Missense_Mutation_p.P213T			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	213	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	GCCCAGGCCTCCTGGACATCA	0.547000													5	7					0.000602214	0.000602938	1	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28304412	28304412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:28304412G>A	ENST00000284987.5	-	6	2081	c.1960C>T	c.(1960-1962)Ccc>Tcc	p.P654S	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	654	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						GCATATTTGGGAACCCATTCC	0.448000													46	24					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93142930	93142930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93142930C>T	ENST00000216487.7	+	8	2605	c.2446C>T	c.(2446-2448)Ccc>Tcc	p.P816S	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	816	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				GCTCATGGACCCCGCCCTGCA	0.622000													12	52					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467747	10467747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10467747C>T	ENST00000382483.3	-	4	4084	c.3861G>A	c.(3859-3861)tcG>tcA	p.S1287S		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1287					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GCTCCAGGTTCGAGCTCGCCC	0.522000													21	174					0	0	1	0	0
ZNF555	148254	broad.mit.edu	37	19	2853194	2853194	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2853194C>T	ENST00000334241.4	+	4	1269	c.1131C>T	c.(1129-1131)ttC>ttT	p.F377F	AC006130.3_ENST00000589365.1_RNA|ZNF555_ENST00000591539.1_Silent_p.F376F	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGACCTTCATTTATCCCC	0.463000													11	42					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85950141	85950141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:85950141C>T	ENST00000373131.1	+	4	1014	c.851C>T	c.(850-852)cCa>cTa	p.P284L	DACH2_ENST00000508860.1_Missense_Mutation_p.P130L|DACH2_ENST00000510272.1_Missense_Mutation_p.P78L|DACH2_ENST00000373125.4_Missense_Mutation_p.P297L	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding	p.P284Q(1)|p.P297Q(1)		breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						GGGGGTGCTCCAACCCTCAAT	0.493000													11	6					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60375621	60375621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60375621G>A	ENST00000371204.3	-	5	739	c.696C>T	c.(694-696)gtC>gtT	p.V232V	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	232					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					TCCATGGAAAGACATTGTAGA	0.358000													13	31					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154624199	154624199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:154624199C>T	ENST00000260010.6	+	1	1548	c.140C>T	c.(139-141)cCc>cTc	p.P47L		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	47					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				AACTCCATTCCCTCAGGGCTC	0.493000													15	24					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230252982	230252982	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230252982G>A	ENST00000341772.4	-	11	1988	c.1855_splice	c.e11+1	p.I618_splice		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	618					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AATACTTACGGATCTCACAGT	0.493000													41	117					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54429267	54429267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54429267G>A	ENST00000334206.5	-	6	846	c.670C>T	c.(670-672)Cat>Tat	p.H224Y	CDC20B_ENST00000322374.6_Missense_Mutation_p.H224Y|CDC20B_ENST00000381375.2_Missense_Mutation_p.H224Y|CDC20B_ENST00000296733.1_Missense_Mutation_p.H224Y			Q86Y33	CD20B_HUMAN	cell division cycle 20B	224										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			CCAGTAATATGAATCTTCACC	0.363000													31	109					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61621019	61621019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61621019C>T	ENST00000583023.1	+	10	2242	c.2231C>T	c.(2230-2232)tCa>tTa	p.S744L	KCNH6_ENST00000314672.5_Missense_Mutation_p.S744L|KCNH6_ENST00000456941.2_Missense_Mutation_p.S691L|KCNH6_ENST00000581784.1_Missense_Mutation_p.S691L	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	744					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GACAACCAGTCAGGTGAGCAA	0.647000													28	62					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84350822	84350822	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:84350822A>T	ENST00000428679.2	-	8	1351	c.758T>A	c.(757-759)gTt>gAt	p.V253D	SNAP91_ENST00000520302.1_Missense_Mutation_p.V253D|SNAP91_ENST00000369694.2_Missense_Mutation_p.V253D|SNAP91_ENST00000439399.2_Missense_Mutation_p.V253D|SNAP91_ENST00000520213.1_Missense_Mutation_p.V253D|SNAP91_ENST00000195649.6_Missense_Mutation_p.V253D|SNAP91_ENST00000521743.1_Missense_Mutation_p.V253D|SNAP91_ENST00000437520.1_Missense_Mutation_p.V253D|SNAP91_ENST00000521485.1_Missense_Mutation_p.V253D			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	253					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TACCTCTGCAACCTTGAGAAA	0.299000													3	2					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230272018	230272018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230272018G>A	ENST00000341772.4	-	10	1787	c.1653C>T	c.(1651-1653)agC>agT	p.S551S		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	551	EGF-like 9.|Follistatin-like.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CGTTCAGACAGCTGACGTTAG	0.532000													43	104					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6947245	6947245	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6947245G>A	ENST00000389658.3	-	61	8854	c.8761C>T	c.(8761-8763)Cga>Tga	p.R2921*		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2921	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGGAGGTTCGAAACTCCAGT	0.562000													23	57					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208218536	208218536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:208218536G>A	ENST00000367033.3	-	19	4272	c.3515C>T	c.(3514-3516)cCt>cTt	p.P1172L		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1172	IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TCCAGAGGCAGGAGGGCAGAG	0.493000													30	88					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79572069	79572069	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:79572069G>A	ENST00000372391.2	-	21	4097	c.4092C>T	c.(4090-4092)atC>atT	p.I1364I	DLG5_ENST00000372388.2_Silent_p.I1024I|DLG5_ENST00000459739.1_5'UTR	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1364	PDZ 3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CTCCACTCACGATGGAGATGC	0.587000													18	73					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36303772	36303772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36303772C>T	ENST00000301175.3	-	2	181	c.164G>A	c.(163-165)gGg>gAg	p.G55E		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	55					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CACCAACTGCCCCTTGCCCAG	0.557000													7	21					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267772	71267772	+	Silent	SNP	G	G	A	rs147891121	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:71267772G>A	ENST00000554752.2	-	2	431	c.432C>T	c.(430-432)ctC>ctT	p.L144L	MAP3K9_ENST00000555993.2_Silent_p.L144L|MAP3K9_ENST00000381250.4_Silent_p.L144L			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	144	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CTTCCAAGGTGAGCTCCGCAA	0.438000													24	63					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61949961	61949961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61949961C>T	ENST00000336844.5	-	4	583	c.432G>A	c.(430-432)gaG>gaA	p.E144E	CSH2_ENST00000560142.1_Silent_p.E87E|CSH2_ENST00000392886.2_Silent_p.E144E|CSH2_ENST00000345366.7_Intron	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	144					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						GGATGCCTTCCTCTAGGTCCT	0.602000													28	101					0	0	1	0	0
KRT39	390792	broad.mit.edu	37	17	39116746	39116746	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39116746G>A	ENST00000355612.2	-	6	1039	c.1004C>T	c.(1003-1005)tCc>tTc	p.S335F	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	335	Coil 2.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				GCACTCTTGGGAATCTCTCTA	0.463000													24	85					0	0	1	0	0
SEMA4C	54910	broad.mit.edu	37	2	97527522	97527522	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97527522G>A	ENST00000305476.5	-	13	1685	c.1553C>T	c.(1552-1554)gCc>gTc	p.A518V		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	518	PSI.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						GACGCTCCAGGCGCAATAGGG	0.647000													17	64					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66259201	66259201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66259201C>T	ENST00000532677.1	+	9	1420	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	DPP3_ENST00000541961.1_Missense_Mutation_p.P321L|DPP3_ENST00000360510.2_Missense_Mutation_p.P321L|DPP3_ENST00000531863.1_Missense_Mutation_p.P341L|DPP3_ENST00000453114.1_Missense_Mutation_p.P321L|DPP3_ENST00000530165.1_Missense_Mutation_p.P291L	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	321					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TACCGCGACCCCTTTGGTTCC	0.612000													88	197					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120369247	120369247	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120369247A>T	ENST00000602047.1	+	14	1494	c.382A>T	c.(382-384)Att>Ttt	p.I128F	PCDP1_ENST00000413369.3_Missense_Mutation_p.I414F|PCDP1_ENST00000597189.1_3'UTR			Q4G0U5	PCDP1_HUMAN		414						cilium	calmodulin binding					Colorectal(110;0.196)					AGGAGATCCTATTTTGGATGA	0.333000													28	72					0	0	1	0	0
PDGFRL	5157	broad.mit.edu	37	8	17447105	17447105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17447105C>T	ENST00000541323.1	+	3	629	c.184C>T	c.(184-186)Cca>Tca	p.P62S	PDGFRL_ENST00000251630.6_Missense_Mutation_p.P62S|PDGFRL_ENST00000398074.3_Missense_Mutation_p.P62S	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	62	Ig-like C2-type 1.					extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		CAATTCAGCACCAAAGACGCA	0.498000													23	112					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13885322	13885322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13885322C>T	ENST00000265104.4	-	19	2863	c.2759G>A	c.(2758-2760)gGa>gAa	p.G920E	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	920	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTCAAAATTTCCTTCTTCTCT	0.383000									Kartagener syndrome				22	42					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94847393	94847393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94847393C>T	ENST00000448921.1	-	5	1304	c.732G>A	c.(730-732)atG>atA	p.M244I	SERPINA1_ENST00000393087.4_Missense_Mutation_p.M244I|SERPINA1_ENST00000449399.3_Missense_Mutation_p.M244I|SERPINA1_ENST00000437397.1_Missense_Mutation_p.M244I|SERPINA1_ENST00000404814.4_Missense_Mutation_p.M244I|SERPINA1_ENST00000402629.1_Missense_Mutation_p.M244I|SERPINA1_ENST00000440909.1_Missense_Mutation_p.M244I|SERPINA1_ENST00000355814.4_Missense_Mutation_p.M244I|SERPINA1_ENST00000393088.4_Missense_Mutation_p.M244I	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	244					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	AACGCTTCATCATAGGCACCT	0.532000													9	58					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	72941367	72941367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:72941367G>A	ENST00000553530.1	+	10	860	c.653G>A	c.(652-654)cGa>cAa	p.R218Q	RGS6_ENST00000343854.6_Missense_Mutation_p.R218Q|RGS6_ENST00000553525.1_Missense_Mutation_p.R218Q|RGS6_ENST00000404301.2_Missense_Mutation_p.R218Q|RGS6_ENST00000554782.1_Missense_Mutation_p.R79Q|RGS6_ENST00000406236.4_Missense_Mutation_p.R218Q|RGS6_ENST00000434263.2_Missense_Mutation_p.R149Q|RGS6_ENST00000556437.1_Missense_Mutation_p.R218Q|RGS6_ENST00000407322.4_Missense_Mutation_p.R218Q|RGS6_ENST00000355512.6_Missense_Mutation_p.R218Q|RGS6_ENST00000555571.1_Missense_Mutation_p.R218Q|RGS6_ENST00000402788.2_Missense_Mutation_p.R218Q	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	218					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		ATGGATATCCGAAAATGTCGA	0.363000													26	51					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3790455	3790455	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3790455G>A	ENST00000262367.5	-	24	4887	c.4078C>T	c.(4078-4080)Cga>Tga	p.R1360*	CREBBP_ENST00000382070.3_Nonsense_Mutation_p.R1322*	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1360	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.R1360*(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCCACCACTCGGACAAAAACC	0.582000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						7	65					0	0	1	0	0
PSAP	5660	broad.mit.edu	37	10	73591668	73591668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73591668G>A	ENST00000394936.3	-	3	331	c.184C>T	c.(184-186)Ccc>Tcc	p.P62S	PSAP_ENST00000394934.1_Missense_Mutation_p.P62S			P07602	SAP_HUMAN	prosaposin	62	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						ATGTCGCAGGGAAGGGATTTC	0.502000													47	123					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33704144	33704144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33704144C>T	ENST00000336934.5	-	5	786	c.670G>A	c.(670-672)Gat>Aat	p.D224N	STARD13_ENST00000255486.4_Missense_Mutation_p.D216N|STARD13_ENST00000399365.3_Missense_Mutation_p.D106N	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	224					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		AGTGGGGCATCCAGCATGACC	0.632000													18	36					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101592065	101592065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101592065G>A	ENST00000284395.5	+	25	3980	c.3580G>A	c.(3580-3582)Gcc>Acc	p.A1194T	LRRK1_ENST00000388948.3_Missense_Mutation_p.A1197T|RP11-505E24.2_ENST00000559857.1_RNA			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1197					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTCCTGACGGCCATCGAGCG	0.637000													7	68					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50666819	50666819	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:50666819C>T	ENST00000371824.1	+	7	1327	c.1070C>T	c.(1069-1071)tCc>tTc	p.S357F	ELAVL4_ENST00000448907.2_Missense_Mutation_p.S360F|ELAVL4_ENST00000371823.4_Missense_Mutation_p.S371F|ELAVL4_ENST00000371819.1_Missense_Mutation_p.S362F|ELAVL4_ENST00000371821.1_Missense_Mutation_p.S376F|ELAVL4_ENST00000371827.1_Missense_Mutation_p.S357F|ELAVL4_ENST00000357083.4_Missense_Mutation_p.S374F			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	371	RRM 3.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						TTGCAAGTTTCCTTTAAAACC	0.458000													20	62					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104679800	104679800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104679800C>T	ENST00000369878.3	+	1	1687	c.1563C>T	c.(1561-1563)ccC>ccT	p.P521P	CNNM2_ENST00000369875.3_Silent_p.P521P|CNNM2_ENST00000457502.2_Silent_p.P279P|CNNM2_ENST00000433628.2_Silent_p.P521P	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	521	CBS 2.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ATAACCACCCCTTGCACTTTG	0.448000													64	145					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55044017	55044017	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55044017G>A	ENST00000335056.3	+	1	41	c.3G>A	c.(1-3)atG>atA	p.M1I																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GTGGCACCATGGCCCCCAAAC	0.507000													51	117					0	0	1	0	0
NR2F1	7025	broad.mit.edu	37	5	92924027	92924027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:92924027G>A	ENST00000327111.3	+	2	2555	c.868G>A	c.(868-870)Gac>Aac	p.D290N		NM_005654.4	NP_005645.1	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	290					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|large_intestine(6)|lung(2)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	21		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		CATGTCTGCCGACCGCGTCGT	0.657000													14	53					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109685438	109685438	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109685438C>T	ENST00000338432.7	+	40	5718	c.5599C>T	c.(5599-5601)Caa>Taa	p.Q1867*	ACACB_ENST00000377848.3_Nonsense_Mutation_p.Q1867*|ACACB_ENST00000543201.1_Nonsense_Mutation_p.Q533*|ACACB_ENST00000377854.5_Nonsense_Mutation_p.Q1797*			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1867	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CCTGACTCCCCAAGACTACAC	0.418000													50	139					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348338	140348338	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348338C>T	ENST00000289269.5	+	1	2519	c.1987C>T	c.(1987-1989)Cga>Tga	p.R663*	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		663	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGTGGTCCGAGATAATGG	0.498000													13	47					0	0	1	0	0
SBK2	646643	broad.mit.edu	37	19	56042656	56042656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56042656G>A	ENST00000413299.1	-	3	347	c.310C>T	c.(310-312)Ctg>Ttg	p.L104L	SBK2_ENST00000344158.3_Silent_p.L104L	NM_001101401.2	NP_001094871.2	P0C263	SBK2_HUMAN	SH3 domain binding kinase family, member 2	104	Protein kinase.						ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						AACTCGTACAGGAAGCCACGG	0.652000													6	14					0	0	1	0	0
SMTNL2	342527	broad.mit.edu	37	17	4500472	4500472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4500472G>A	ENST00000389313.4	+	7	1180	c.1113G>A	c.(1111-1113)gtG>gtA	p.V371V	SMTNL2_ENST00000338859.4_Silent_p.V227V	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	371	CH.									breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		TGCAGCACGTGGACCTGCAGA	0.612000													19	26					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138522699	138522699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138522699G>A	ENST00000440172.1	-	20	5805	c.5757C>T	c.(5755-5757)ctC>ctT	p.L1919L	KIAA1549_ENST00000422774.1_Silent_p.L1935L|TMEM213_ENST00000413208.1_Silent_p.R80R|KIAA1549_ENST00000242365.4_Silent_p.L1869L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1935						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						AGAGCCGGAGGAGCTCCTCGC	0.617000			O	BRAF	pilocytic astrocytoma								13	35					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61465948	61465948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61465948G>A	ENST00000398019.2	+	6	890	c.565G>A	c.(565-567)Gaa>Aaa	p.E189K	SERPINB7_ENST00000336429.2_Missense_Mutation_p.E189K|SERPINB7_ENST00000546027.1_Missense_Mutation_p.E189K|SERPINB7_ENST00000540675.1_Missense_Mutation_p.E172K	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	189					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				CACCAAGAGCGAAACCATAAA	0.423000													40	85					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100155173	100155173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100155173G>A	ENST00000263174.4	+	7	1732	c.1357G>A	c.(1357-1359)Gag>Aag	p.E453K	PALMD_ENST00000605497.1_Missense_Mutation_p.E453K	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	453	Poly-Glu.				regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		TGAGGAGGAGGAGGATGAAGG	0.483000													21	59					0	0	1	0	0
TTC5	91875	broad.mit.edu	37	14	20767011	20767011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20767011G>A	ENST00000258821.3	-	5	640	c.584C>T	c.(583-585)tCt>tTt	p.S195F		NM_138376.2	NP_612385.2	Q8N0Z6	TTC5_HUMAN	tetratricopeptide repeat domain 5	195					DNA repair	cytoplasm|nucleus	binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_cancers(95;0.00092)		Epithelial(56;1.1e-06)|all cancers(55;8.07e-06)	GBM - Glioblastoma multiforme(265;0.0106)		CTGGCCAGTAGAGAAGTAAAG	0.423000													20	38					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26966471	26966471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26966471G>A	ENST00000528896.2	-	11	1165	c.1091C>T	c.(1090-1092)aCc>aTc	p.T364I	KIAA0100_ENST00000544884.1_Missense_Mutation_p.T221I|KIAA0100_ENST00000389003.3_Missense_Mutation_p.T221I	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	364						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					GAGGTCAATGGTGGTCACCTG	0.453000													25	22					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29012441	29012441	+	Missense_Mutation	SNP	C	C	T	rs55974987	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29012441C>T	ENST00000282397.4	-	4	681	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	FLT1_ENST00000539099.1_Missense_Mutation_p.E144K|FLT1_ENST00000541932.1_Missense_Mutation_p.E144K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	144			E -> K (in dbSNP:rs55974987).		cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGTATAATTTCGGGGATTTCA	0.383000													9	43					0	0	1	0	0
MFAP5	8076	broad.mit.edu	37	12	8800731	8800731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8800731G>A	ENST00000359478.2	-	10	665	c.478C>T	c.(478-480)Cct>Tct	p.P160S	MFAP5_ENST00000433590.2_Missense_Mutation_p.P135S|MFAP5_ENST00000396549.2_Missense_Mutation_p.P150S|MFAP5_ENST00000540087.1_Missense_Mutation_p.P150S|MFAP5_ENST00000543369.1_Missense_Mutation_p.P138S|MFAP5_ENST00000535336.1_Missense_Mutation_p.P96S	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	160						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					TCACAGGGAGGAAGTCGGAAG	0.478000													14	56					0	0	1	0	0
NIPAL4	348938	broad.mit.edu	37	5	156899784	156899784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156899784C>T	ENST00000311946.7	+	6	1333	c.1217C>T	c.(1216-1218)gCt>gTt	p.A406V	ADAM19_ENST00000430702.2_Intron|NIPAL4_ENST00000435489.2_Missense_Mutation_p.A387V	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	406						integral to membrane	receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						ATGCTGCATGCTTTCAAAGAC	0.547000													13	40					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233986949	233986949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233986949G>A	ENST00000359570.5	+	3	331	c.331G>A	c.(331-333)Gac>Aac	p.D111N	INPP5D_ENST00000538935.1_Missense_Mutation_p.D111N|INPP5D_ENST00000474278.1_3'UTR			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	111					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CACAGGCGACGACCCTGAGGA	0.567000													13	29					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172585245	172585245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:172585245C>T	ENST00000534253.2	+	14	1444	c.1276C>T	c.(1276-1278)Cat>Tat	p.H426Y	DYNC1I2_ENST00000397119.3_Missense_Mutation_p.H426Y|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.H418Y|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.H400Y|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.H420Y|DYNC1I2_ENST00000410079.3_Missense_Mutation_p.H418Y|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.H400Y|DYNC1I2_ENST00000409197.1_Missense_Mutation_p.H400Y|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.H426Y|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.H426Y|DYNC1I2_ENST00000409317.1_Missense_Mutation_p.H420Y			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	426					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			GGAGTTGGTTCATAAACAGTC	0.363000													6	16					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216496929	216496929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216496929G>A	ENST00000366943.2	-	8	1823	c.1437C>T	c.(1435-1437)ttC>ttT	p.F479F	USH2A_ENST00000307340.3_Silent_p.F479F|USH2A_ENST00000366942.3_Silent_p.F479F			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	479	Laminin N-terminal.		F -> S.		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.F479F(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGCTTTTACGAACTCTTGAA	0.408000										HNSCC(13;0.011)			16	172					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100523597	100523597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:100523597C>T	ENST00000358544.2	+	29	4676	c.4565C>T	c.(4564-4566)aCc>aTc	p.T1522I	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.T1497I	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1522					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTACCAAAGACCCAAAAAGAG	0.358000													15	48					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72234479	72234479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:72234479G>A	ENST00000340726.3	-	5	866	c.227C>T	c.(226-228)cCa>cTa	p.P76L	EYA1_ENST00000303824.7_Missense_Mutation_p.P76L|EYA1_ENST00000388742.4_Missense_Mutation_p.P76L|EYA1_ENST00000388741.2_Missense_Mutation_p.P43L|EYA1_ENST00000388743.2_Missense_Mutation_p.P76L|EYA1_ENST00000388740.3_Missense_Mutation_p.P43L|EYA1_ENST00000419131.1_Missense_Mutation_p.P76L	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	76					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AGTTGGTCGTGGGCTGAAACT	0.343000													18	63					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53740812	53740812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53740812G>A	ENST00000333952.4	-	5	1333	c.1168C>T	c.(1168-1170)Ctt>Ttt	p.L390F	ZNF677_ENST00000598513.1_Missense_Mutation_p.L390F			Q86XU0	ZN677_HUMAN	zinc finger protein 677	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		TGTTGGGTAAGGCTTGAACGT	0.413000													11	90					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43821264	43821264	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43821264C>T	ENST00000382031.1	+	5	8338	c.8307C>T	c.(8305-8307)ctC>ctT	p.L2769L	MAP1A_ENST00000300231.5_Silent_p.L2531L|MAP1A_ENST00000399453.1_Silent_p.L2531L			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2531						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGGCAGCCCTCGACTCAGATG	0.587000													62	124					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44261954	44261954	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44261954G>A	ENST00000315087.7	-	6	1303	c.643C>T	c.(643-645)Ccc>Tcc	p.P215S	ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000538168.1_Missense_Mutation_p.P251S|ST8SIA5_ENST00000536490.1_Missense_Mutation_p.P184S	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	215					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						ATGATGCTGGGGTTCACAGTG	0.542000													11	29					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56345295	56345295	+	Silent	SNP	C	C	T	rs149585110	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56345295C>T	ENST00000262290.4	+	13	2395	c.2079C>T	c.(2077-2079)ttC>ttT	p.F693F	LPO_ENST00000582328.1_Silent_p.F610F|LPO_ENST00000543544.1_Silent_p.F634F|LPO_ENST00000421678.2_Silent_p.F610F	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	693					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						CCTATGACTTCGTGGATTGCT	0.567000													44	85					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15904925	15904925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15904925C>T	ENST00000308940.8	+	1	165	c.67C>T	c.(67-69)Ctc>Ttc	p.L23F		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CTTCCCCCACCTCCAGCTGAT	0.587000													60	178					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121973125	121973125	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121973125G>A	ENST00000498619.1	+	2	527	c.89G>A	c.(88-90)gGg>gAg	p.G30E	CASR_ENST00000296154.5_Missense_Mutation_p.G30E|CASR_ENST00000490131.1_Missense_Mutation_p.G30E	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	30					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CAAAAGAAGGGGGACATTATC	0.517000													44	135					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3293298	3293298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3293298G>A	ENST00000219596.1	-	10	2228	c.2189C>T	c.(2188-2190)tCc>tTc	p.S730F	MEFV_ENST00000541159.1_3'UTR|MEFV_ENST00000339854.4_Missense_Mutation_p.S550F|MEFV_ENST00000536379.1_Missense_Mutation_p.S519F	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	730	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	ATTGTAAAAGGAGATGCTTCC	0.542000													24	106					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121693987	121693987	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121693987C>T	ENST00000393386.2	+	26	6687	c.6276C>T	c.(6274-6276)ttC>ttT	p.F2092F	PTPRZ1_ENST00000449182.1_Silent_p.F1225F	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2092	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GCAATGAATTCATCATTACCC	0.413000													63	154					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142488856	142488856	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142488856C>T	ENST00000430863.1	-	0	1185					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CAGCGCAGGTCCTCCGAGTTC	0.662000													7	6					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15706608	15706608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15706608G>A	ENST00000396368.3	-	17	3486	c.3280C>T	c.(3280-3282)Cct>Tct	p.P1094S	KIAA0430_ENST00000602337.1_Missense_Mutation_p.P1091S|KIAA0430_ENST00000551742.1_Missense_Mutation_p.P1094S|KIAA0430_ENST00000344181.3_Missense_Mutation_p.P696S|KIAA0430_ENST00000548025.1_Missense_Mutation_p.P1091S|KIAA0430_ENST00000540441.2_Missense_Mutation_p.P929S	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1093						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TTACCTACAGGACTCTTCGAA	0.463000													50	156					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101748762	101748762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101748762C>T	ENST00000506729.1	-	9	1729	c.1558G>A	c.(1558-1560)Gat>Aat	p.D520N	SLCO6A1_ENST00000379810.1_Missense_Mutation_p.D267N|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.D267N|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.D458N|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.D520N			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	520	Kazal-like.					integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TCAATATCATCTCTTCCACAT	0.313000													17	36					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327514	57327514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57327514C>T	ENST00000326441.9	-	10	2659	c.2296G>A	c.(2296-2298)Gaa>Aaa	p.E766K	PEG3_ENST00000423103.2_Missense_Mutation_p.E766K|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.E640K|PEG3_ENST00000598410.1_Missense_Mutation_p.E642K|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	766					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TAGACATTTTCCTTAGTGGGA	0.428000													57	218					0	0	1	0	0
COLEC10	10584	broad.mit.edu	37	8	120103399	120103399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:120103399G>A	ENST00000332843.2	+	3	273	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	COLEC10_ENST00000521788.1_3'UTR	NM_006438.3	NP_006429.2	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 (C-type lectin)	78	Collagen-like.					collagen|cytoplasm	mannose binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			AATTAAAGGAGAACTGGGTGA	0.383000													9	88					0	0	1	0	0
TPP1	1200	broad.mit.edu	37	11	6635912	6635912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6635912G>A	ENST00000533371.1	-	12	1626	c.828C>T	c.(826-828)acC>acT	p.T276T	TPP1_ENST00000299427.6_Silent_p.T519T			O14773	TPP1_HUMAN	tripeptidyl peptidase I	519					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		GGCAGCCACGGGTTACCTAGG	0.532000													27	93					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176308482	176308482	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176308482G>A	ENST00000292432.5	-	18	2539	c.2448C>T	c.(2446-2448)ccC>ccT	p.P816P		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	816	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGAGGTCAGGGGTAGCCCCA	0.652000													10	31					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65245923	65245923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65245923G>A	ENST00000389722.3	-	21	4568	c.4515C>T	c.(4513-4515)gaC>gaT	p.D1505D	SPTB_ENST00000389720.3_Silent_p.D1505D|SPTB_ENST00000389721.5_Silent_p.D1505D|SPTB_ENST00000556626.1_Silent_p.D1505D|SPTB_ENST00000542895.1_Silent_p.D1505D	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1505					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TAGTGCCATAGTCGGCTGACT	0.582000													11	32					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53694250	53694250	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53694250C>T	ENST00000288139.3	+	5	832	c.714C>T	c.(712-714)gcC>gcT	p.A238A	CACNA1D_ENST00000422281.2_Silent_p.A238A|CACNA1D_ENST00000350061.5_Silent_p.A238A	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	238					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ATGTCAAAGCCCTCCGTGCCT	0.453000													25	75					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440076	124440076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124440076G>A	ENST00000284287.3	+	1	184	c.112G>A	c.(112-114)Gca>Aca	p.A38T		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		AACGAAGAGAGCAGACCTCCA	0.527000													26	84					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96123893	96123893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:96123893C>T	ENST00000453304.1	-	12	2473	c.2125G>A	c.(2125-2127)Gat>Aat	p.D709N		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	709	Interaction with DCC (By similarity).				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TTCAGGGCATCCTGGGTGTCA	0.597000													10	12					0	0	1	0	0
MFAP5	8076	broad.mit.edu	37	12	8802109	8802109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8802109C>T	ENST00000359478.2	-	9	584	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	MFAP5_ENST00000433590.2_Missense_Mutation_p.E108K|MFAP5_ENST00000396549.2_Missense_Mutation_p.E123K|MFAP5_ENST00000540087.1_Missense_Mutation_p.E123K|MFAP5_ENST00000543369.1_Missense_Mutation_p.E111K|MFAP5_ENST00000535336.1_Intron	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	133						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					TTCATAGCTTCGTGTTCCTTA	0.433000													19	42					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40720956	40720956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40720956C>T	ENST00000253055.3	+	10	2910	c.2622C>T	c.(2620-2622)ttC>ttT	p.F874F		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	874					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						CCCCTGAGTTCCCAGGCCGCC	0.711000													9	30					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47274758	47274758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47274758G>A	ENST00000396220.1	-	17	1912	c.1890C>T	c.(1888-1890)ccC>ccT	p.P630P	PREX1_ENST00000371941.3_Silent_p.P630P			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	630	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CCTCCTCCTGGGGCAGGATCT	0.672000											OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	268					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	44005977	44005977	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44005977C>T	ENST00000292140.5	-	4	803	c.443G>A	c.(442-444)cGa>cAa	p.R148Q	PHLDB3_ENST00000599242.1_Missense_Mutation_p.R148Q	NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	148										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				AGCGGCCACTCGCTCCCCAGC	0.706000													4	8					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793010	65793010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65793010C>T	ENST00000312106.5	-	1	978	c.841G>A	c.(841-843)Gac>Aac	p.D281N		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	281	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						tggggatggtcgccatggtgg	0.577000													3	11					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32200883	32200883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32200883C>T	ENST00000400246.1	+	17	1341	c.1199C>T	c.(1198-1200)cCt>cTt	p.P400L	DEPDC5_ENST00000400242.3_Missense_Mutation_p.P400L|DEPDC5_ENST00000400248.1_Missense_Mutation_p.P400L|DEPDC5_ENST00000535622.1_Missense_Mutation_p.P400L|DEPDC5_ENST00000536766.1_Missense_Mutation_p.P372L|DEPDC5_ENST00000382111.2_Missense_Mutation_p.P400L|DEPDC5_ENST00000400249.2_Missense_Mutation_p.P400L|DEPDC5_ENST00000266091.3_Missense_Mutation_p.P400L|DEPDC5_ENST00000382105.2_Missense_Mutation_p.P400L|DEPDC5_ENST00000382112.3_Missense_Mutation_p.P400L			O75140	DEPD5_HUMAN	DEP domain containing 5	400					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TATAATATCCCTCACTGGATA	0.433000													21	230					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19176015	19176015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19176015G>A	ENST00000375371.3	-	4	1308	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	429					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCAGGAGAGTGAAGTTGACCT	0.562000													10	50					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131415460	131415460	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:131415460C>T	ENST00000512055.1	-	9	2559	c.432_splice	c.e9-1	p.V145_splice	CPNE4_ENST00000512332.1_Splice_Site_p.V163_splice|CPNE4_ENST00000502818.1_Splice_Site_p.V163_splice|CPNE4_ENST00000511604.1_Splice_Site_p.V145_splice|CPNE4_ENST00000429747.1_Splice_Site_p.V145_splice			Q96A23	CPNE4_HUMAN	copine IV	145	C2 2.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						TCAGCAATCACCTAAAGGAAA	0.403000													25	78					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606558	84606558	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84606558G>A	ENST00000344803.2	+	4	1220	c.1173G>A	c.(1171-1173)ggG>ggA	p.G391G		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CCTTTTTAGGGGGGCACTCTG	0.473000													16	49					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90770548	90770548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90770548G>A	ENST00000354366.3	-	5	968	c.736C>T	c.(736-738)Ccc>Tcc	p.P246S	NRDE2_ENST00000357904.3_Missense_Mutation_p.P15S	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		TCAGATGAGGGAGGTTCAGTT	0.448000													43	120					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241700753	241700753	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241700753A>C	ENST00000498729.2	-	24	2404	c.2158T>G	c.(2158-2160)Ttc>Gtc	p.F720V	KIF1A_ENST00000320389.7_Missense_Mutation_p.F711V	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	711					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CACTTCCGGAAGGCCCAGAGC	0.622000													23	46					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33246090	33246090	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33246090C>T	ENST00000404816.2	+	3	1033	c.680C>T	c.(679-681)tCg>tTg	p.S227L	LTBP1_ENST00000354476.3_Missense_Mutation_p.S227L			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	227					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAGGACACCTCGTCACCAGTC	0.552000													78	215					0	0	1	0	0
ACVR1	90	broad.mit.edu	37	2	158617438	158617438	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158617438G>T	ENST00000263640.3	-	9	1647	c.1218C>A	c.(1216-1218)gcC>gcA	p.A406A	ACVR1_ENST00000434821.1_Silent_p.A406A|ACVR1_ENST00000410057.2_Silent_p.A406A|ACVR1_ENST00000409283.2_Silent_p.A406A	NM_001105.4	NP_001096.1	Q04771	ACVR1_HUMAN	activin A receptor, type I	406	Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	19				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	CAAGTCCAAAGGCCCAAATAT	0.458000													5	75					1.024e-07	1.02717e-07	1	1	0
HOXC10	3226	broad.mit.edu	37	12	54379177	54379177	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54379177G>A	ENST00000303460.4	+	1	208	c.134G>A	c.(133-135)aGg>aAg	p.R45K	HOXC-AS3_ENST00000514702.1_RNA	NM_017409.3	NP_059105.2	Q9NYD6	HXC10_HUMAN	homeobox C10	45					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R45K(1)		endometrium(2)|large_intestine(3)|lung(14)|pancreas(1)	20						GGGGTGATGAGGGGCTGCGGG	0.662000													13	58					0	0	1	0	0
ADCYAP1	116	broad.mit.edu	37	18	909582	909582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:909582G>A	ENST00000579794.1	+	4	755	c.477G>A	c.(475-477)ggG>ggA	p.G159G	ADCYAP1_ENST00000450565.3_Silent_p.G159G	NM_001117.3	NP_001108.2	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary)	159					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						CCGTCCTAGGGAAGAGGTATA	0.512000													40	199					0	0	1	0	0
RBPMS2	348093	broad.mit.edu	37	15	65042566	65042566	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65042566G>A	ENST00000300069.4	-	3	447	c.180C>T	c.(178-180)tcC>tcT	p.S60S	RBPMS2_ENST00000560606.1_5'UTR	NM_194272.1	NP_919248.1	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	60	RRM.						nucleic acid binding|nucleotide binding			breast(1)|large_intestine(3)|lung(3)|prostate(1)	8						GCTTGATCAGGGACCCTTCAT	0.572000													84	241					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38647586	38647586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38647586G>A	ENST00000413689.1	-	10	1387	c.1194C>T	c.(1192-1194)ttC>ttT	p.F398F	SCN5A_ENST00000423572.2_Silent_p.F398F|SCN5A_ENST00000425664.1_Silent_p.F398F|SCN5A_ENST00000455624.2_Silent_p.F398F|SCN5A_ENST00000450102.2_Silent_p.F398F|SCN5A_ENST00000449557.2_Silent_p.F398F|SCN5A_ENST00000414099.2_Silent_p.F398F|SCN5A_ENST00000451551.2_Silent_p.F398F|SCN5A_ENST00000333535.4_Silent_p.F398F|SCN5A_ENST00000443581.1_Silent_p.F398F	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	398					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGGACCCCAGGAAGATGACAA	0.577000													15	64					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119914839	119914839	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:119914839C>T	ENST00000331113.4	+	1	1118	c.153C>T	c.(151-153)cgC>cgT	p.R51R		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	51					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					GTGGCACCCGCTTCCAGACGT	0.572000													17	291					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98449122	98449122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98449122C>T	ENST00000450876.1	-	6	1991	c.676G>A	c.(676-678)Gac>Aac	p.D226N	TMEM130_ENST00000546258.1_Missense_Mutation_p.D291N|TMEM130_ENST00000416379.2_Missense_Mutation_p.D310N|TMEM130_ENST00000345589.4_Missense_Mutation_p.D208N|TMEM130_ENST00000339375.4_Missense_Mutation_p.D310N			Q8N3G9	TM130_HUMAN	transmembrane protein 130	310	PKD.					Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAGCAGTAGTCCCCAGGGTCC	0.592000													24	42					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15815444	15815444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15815444C>T	ENST00000338282.6	-	32	4519	c.4413G>A	c.(4411-4413)agG>agA	p.R1471R	MYH11_ENST00000300036.5_Silent_p.R1471R|NDE1_ENST00000342673.5_Intron|MYH11_ENST00000452625.2_Silent_p.R1478R|MYH11_ENST00000396324.3_Silent_p.R1478R|NDE1_ENST00000396355.1_Intron|NDE1_ENST00000396354.1_Intron|MYH11_ENST00000576790.1_Silent_p.R1471R	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1471					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CAGCTCTGTCCCTCTCATCCG	0.557000			T	CBFB	AML								12	70					0	0	1	0	0
TDG	6996	broad.mit.edu	37	12	104370702	104370702	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104370702C>T	ENST00000392872.3	+	2	264	c.30C>T	c.(28-30)tcC>tcT	p.S10S	TDG_ENST00000544861.1_Intron|TDG_ENST00000266775.9_Silent_p.S6S	NM_003211.4	NP_003202.3	Q13569	TDG_HUMAN	thymine-DNA glycosylase	10					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			large_intestine(2)|lung(14)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(302;0.00114)		TCAGCTATTCCCTTCAGCAAG	0.353000								Base excision repair (BER), DNA glycosylases					15	40					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196183	207196183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207196183C>T	ENST00000359470.5	-	4	1175	c.926G>A	c.(925-927)aGc>aAc	p.S309N	C1orf116_ENST00000461135.2_Missense_Mutation_p.S63N	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	309						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					GCTTCGGCTGCTCTTCAGAAC	0.587000													28	50					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54959101	54959101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54959101G>A	ENST00000273286.5	-	2	311	c.149C>T	c.(148-150)cCt>cTt	p.P50L	CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|LRTM1_ENST00000493075.1_5'UTR|CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000490478.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	50	LRRNT.					integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		TCGAGTCTGAGGAGGTAAATG	0.473000													6	37					0	0	1	0	0
PDSS1	23590	broad.mit.edu	37	10	26994270	26994270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26994270C>T	ENST00000376215.5	+	4	336	c.283C>T	c.(283-285)Cct>Tct	p.P95S	PDSS1_ENST00000376203.5_Missense_Mutation_p.P95S	NM_014317.3	NP_055132.2	Q5T2R2	DPS1_HUMAN	prenyl (decaprenyl) diphosphate synthase, subunit 1	95					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity			autonomic_ganglia(1)|endometrium(1)|kidney(7)|large_intestine(6)|lung(5)|prostate(1)	21						ATACACCGATCCTTTCAAACT	0.383000													17	39					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207590	58207590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58207590C>T	ENST00000377918.3	+	1	936	c.910C>T	c.(910-912)Cgt>Tgt	p.R304C		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	304	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGGCCTAATCCGTGTGAAGGG	0.577000													18	44					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113102449	113102449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113102449G>A	ENST00000316851.7	+	9	1142	c.1142G>A	c.(1141-1143)gGa>gAa	p.G381E	NCAM1_ENST00000401611.2_Missense_Mutation_p.G390E|NCAM1_ENST00000533760.1_Missense_Mutation_p.G263E|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	391	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ACTGATGCCGGAGAGTACATC	0.597000													30	76					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55782877	55782877	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55782877G>A	ENST00000373965.2	-	20	2716	c.2322C>T	c.(2320-2322)tcC>tcT	p.S774S	PCDH15_ENST00000395445.1_Silent_p.S774S|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Silent_p.S772S|PCDH15_ENST00000395433.1_Silent_p.S745S|PCDH15_ENST00000395430.1_Silent_p.S767S|PCDH15_ENST00000373955.1_Silent_p.S767S|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000361849.3_Silent_p.S767S|PCDH15_ENST00000395438.1_Silent_p.S767S|PCDH15_ENST00000409834.1_Silent_p.S378S|PCDH15_ENST00000437009.1_Silent_p.S696S|PCDH15_ENST00000320301.6_Silent_p.S767S|PCDH15_ENST00000395432.2_Silent_p.S730S	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	767	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCTCCCATTGGATGTGATAC	0.393000										HNSCC(58;0.16)			6	75					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55710208	55710208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55710208G>A	ENST00000376350.3	-	8	1515	c.1493C>T	c.(1492-1494)cCc>cTc	p.P498L	PTPRH_ENST00000263434.5_Missense_Mutation_p.P320L|PTPRH_ENST00000588559.1_5'UTR	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	498	Fibronectin type-III 6.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TGGGCCCTGGGGAGCTGTCCA	0.592000													7	34					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124403488	124403488	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124403488G>A	ENST00000409039.3	+	64	11169	c.11144G>A	c.(11143-11145)gGc>gAc	p.G3715D		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3715					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TATAACCACGGCTGCACAGGT	0.498000													6	72					0	0	1	0	0
IL1F10	84639	broad.mit.edu	37	2	113832841	113832841	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113832841G>A	ENST00000393197.2	+	4	780	c.359G>A	c.(358-360)tGg>tAg	p.W120*	IL1F10_ENST00000341010.2_Nonsense_Mutation_p.W120*|IL1F10_ENST00000337569.3_Nonsense_Mutation_p.W120*	NM_032556.5	NP_115945.4	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	120						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			endometrium(1)|lung(6)|ovary(1)	8						TGGCCTGGCTGGTTCCTGTGT	0.592000													37	147					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202272434	202272434	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202272434G>A	ENST00000367278.3	+	10	1046	c.957G>A	c.(955-957)caG>caA	p.Q319Q	LGR6_ENST00000439764.2_Silent_p.Q180Q|LGR6_ENST00000308543.3_3'UTR|LGR6_ENST00000255432.7_Silent_p.Q267Q	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	319						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						TGGACATCCAGGAGTTTCCAG	0.502000													6	73					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38822908	38822908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38822908C>T	ENST00000303592.3	-	2	1488	c.1230G>A	c.(1228-1230)gaG>gaA	p.E410E	RP3-434P1.6_ENST00000433230.1_RNA	NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	410					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					TGATGCCCGCCTCCTCCTTGG	0.677000													46	116					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8146261	8146261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8146261C>T	ENST00000600128.1	-	58	7731	c.7317G>A	c.(7315-7317)gaG>gaA	p.E2439E	FBN3_ENST00000601739.1_Silent_p.E2439E|FBN3_ENST00000270509.2_Silent_p.E2439E			Q75N90	FBN3_HUMAN	fibrillin 3	2439	EGF-like 39; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TCCTGCCATCCTCCTCCAGCA	0.582000													11	29					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30934525	30934525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30934525C>T	ENST00000355537.3	+	2	203	c.56C>T	c.(55-57)cCc>cTc	p.P19L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GAAGCTGAGCCCCACCTGAGT	0.622000													52	122					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44673604	44673604	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44673604G>A	ENST00000454036.1	+	12	1539		c.e12-1		SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000243964.3_Splice_Site	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5						potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CATCATTCCAGGTTTGGCGAA	0.562000													70	130					0	0	1	0	0
SCN1B	6324	broad.mit.edu	37	19	35524582	35524582	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35524582C>T	ENST00000262631.5	+	3	524	c.387C>T	c.(385-387)ttC>ttT	p.F129F	SCN1B_ENST00000595652.1_Intron|SCN1B_ENST00000415950.3_Silent_p.F129F|SCN1B_ENST00000596348.1_3'UTR	NM_001037.4	NP_001028.1	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta subunit	129	Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	11	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGCTCTTCTTCGAAAACTACG	0.552000													52	122					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71041035	71041035	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:71041035G>A	ENST00000452400.2	-	17	3686	c.3505C>T	c.(3505-3507)Cgt>Tgt	p.R1169C	NCOA2_ENST00000267974.4_Missense_Mutation_p.R257C	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1169					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GGCTGCATACGGAGTGTGGCA	0.552000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								17	34					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174955	63174955	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:63174955G>A	ENST00000322893.7	-	11	2506	c.2238C>T	c.(2236-2238)tcC>tcT	p.S746S	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	746					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTCCGGTGATGGAGGCTCCAT	0.537000													7	86					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26690364	26690364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26690364C>T	ENST00000529632.2	+	3	1138	c.942C>T	c.(940-942)gtC>gtT	p.V314V	SEZ6L_ENST00000343706.4_Silent_p.V314V|SEZ6L_ENST00000360929.3_Silent_p.V314V|SEZ6L_ENST00000404234.3_Silent_p.V314V|SEZ6L_ENST00000248933.6_Silent_p.V314V|SEZ6L_ENST00000402979.1_Silent_p.V87V|SEZ6L_ENST00000403121.1_Silent_p.V87V	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	314	CUB 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						ACGTGACAGTCTACACTGGCT	0.552000													47	70					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103772	52103772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52103772C>T	ENST00000361781.2	-	7	1062	c.103G>A	c.(103-105)Gac>Aac	p.D35N	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Missense_Mutation_p.D35N	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	41	SAM.				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						TTGATCAAGTCCTGGCCTGTG	0.512000													29	57					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566491	45566491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:45566491C>T	ENST00000588982.1	-	3	1489	c.988G>A	c.(988-990)Gac>Aac	p.D330N	ZBTB7C_ENST00000586438.1_Missense_Mutation_p.D330N|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.D330N|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.D330N|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.D330N			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	330						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GCACCGTAGTCGTTCTCCGCC	0.637000													33	66					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106729593	106729593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:106729593G>A	ENST00000299045.3	+	7	1123	c.949G>A	c.(949-951)Gaa>Aaa	p.E317K		NM_152772.1	NP_689985.1	Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	317										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						TCAGAAAAAAGAATTACCAGA	0.388000													12	64					0	0	1	0	0
ZFP62	643836	broad.mit.edu	37	5	180277487	180277487	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180277487G>A	ENST00000359141.6	-	3	1147	c.828C>T	c.(826-828)ccC>ccT	p.P276P	ZFP62_ENST00000512132.1_Silent_p.P303P|ZFP62_ENST00000506377.1_Intron|ZFP62_ENST00000502412.1_Silent_p.P336P	NM_152283.4	NP_689496.4	Q8NB50	ZFP62_HUMAN	ZFP62 zinc finger protein	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|endometrium(2)|pancreas(1)	4	all_cancers(89;4.01e-05)|all_epithelial(37;4.69e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00469)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACATTTATAGGGTTTATCTC	0.378000													3	4					0	0	1	0	0
AGMAT	79814	broad.mit.edu	37	1	15909693	15909693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15909693G>A	ENST00000375826.3	-	2	612	c.470C>T	c.(469-471)aCc>aTc	p.T157I	DNAJC16_ENST00000483270.1_Intron	NM_024758.4	NP_079034.3	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase)	157					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(2)|skin(1)	12		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)		ATTACCCAAGGTCAGAGGAAT	0.493000													15	43					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631512	32631512	+	Missense_Mutation	SNP	G	G	A	rs56107531		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32631512G>A	ENST00000242310.4	-	1	4155	c.4066C>T	c.(4066-4068)Cgc>Tgc	p.R1356C		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1356			R -> C (in dbSNP:rs56107531).		male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GATTTTCTGCGAACCTCATGC	0.398000													103	213					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8200927	8200927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8200927G>A	ENST00000600128.1	-	13	1923	c.1509C>T	c.(1507-1509)ggC>ggT	p.G503G	FBN3_ENST00000601739.1_Silent_p.G503G|FBN3_ENST00000270509.2_Silent_p.G503G			Q75N90	FBN3_HUMAN	fibrillin 3	503	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGACACAGCGGCCCAGGTGAC	0.632000													7	25					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168678406	168678406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168678406C>T	ENST00000519560.1	-	2	674	c.255G>A	c.(253-255)aaG>aaA	p.K85K	SLIT3_ENST00000521130.1_5'UTR|SLIT3_ENST00000332966.8_Silent_p.K85K|SLIT3_ENST00000404867.3_Silent_p.K85K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	85					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCGGAGGTTCTTGAGCCCAG	0.443000													28	89					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219299356	219299356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219299356G>A	ENST00000248444.5	+	14	1696	c.1608G>A	c.(1606-1608)cgG>cgA	p.R536R	VIL1_ENST00000392114.2_Silent_p.R225R	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	536	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCCAGCGCGGGCCAATTTCC	0.567000													31	91					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10369690	10369690	+	Missense_Mutation	SNP	G	G	A	rs112133139		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10369690G>A	ENST00000255381.2	-	4	358	c.248C>T	c.(247-249)cCc>cTc	p.P83L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	83	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.P83L(1)		NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTCATATTTGGGAGGGTTCAT	0.438000													56	81					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76868005	76868005	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76868005G>A	ENST00000409709.3	+	7	962	c.690G>A	c.(688-690)gcG>gcA	p.A230A	MYO7A_ENST00000409619.2_Silent_p.A219A|MYO7A_ENST00000458637.2_Silent_p.A230A|MYO7A_ENST00000409893.1_Silent_p.A230A	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	230	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TCGAGGGCGCGAAGATTGAGC	0.582000													25	57					0	0	1	0	0
AADACL3	126767	broad.mit.edu	37	1	12785747	12785747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12785747C>T	ENST00000332530.3	+	3	853	c.627C>T	c.(625-627)ctC>ctT	p.L209L	AADACL3_ENST00000359318.5_Silent_p.L279L	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	279							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCTCAGCTCCCGGAAACCT	0.522000													58	89					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42509145	42509145	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42509145G>A	ENST00000381668.5	-	23	2205	c.1974C>T	c.(1972-1974)gcC>gcT	p.A658A	ATP8A1_ENST00000264449.10_Silent_p.A643A	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	658					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	TATCCTCAATGGCTGTTGCTC	0.343000													40	123					0	0	1	0	0
C2CD4A	145741	broad.mit.edu	37	15	62359880	62359880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:62359880C>T	ENST00000355522.5	+	2	209	c.68C>T	c.(67-69)cCg>cTg	p.P23L		NM_207322.2	NP_997205.2	Q8NCU7	C2C4A_HUMAN	C2 calcium-dependent domain containing 4A	23						nucleus											TGGCTTCTCCCGGGTCGGGCC	0.667000													22	25					0	0	1	0	0
SPANXN3	139067	broad.mit.edu	37	X	142596707	142596707	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142596707G>A	ENST00000370503.2	-	2	446	c.363C>T	c.(361-363)tcC>tcT	p.S121S	GS1-256O22.5_ENST00000431432.1_RNA	NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	121										endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCTGTGAGGATCCTTCAG	0.458000													69	43					0	0	1	0	0
WFDC5	149708	broad.mit.edu	37	20	43739057	43739057	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43739057G>A	ENST00000307971.4	-	3	429	c.351C>T	c.(349-351)tgC>tgT	p.C117C	WFDC5_ENST00000372789.4_Silent_p.C117C			Q8TCV5	WFDC5_HUMAN	WAP four-disulfide core domain 5	117	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				CAGGATCCCGGCAATCCCGCC	0.607000													6	19					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129095170	129095170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129095170C>T	ENST00000249344.2	+	8	832	c.792C>T	c.(790-792)ttC>ttT	p.F264F	STRIP2_ENST00000435494.2_Silent_p.F264F	NM_020704.2	NP_065755.1			striatin interacting protein 2																		CTCCTCACTTCCCCATAAAGA	0.517000													13	167					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914613	51914613	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51914613T>G	ENST00000353836.5	-	10	1770	c.1549A>C	c.(1549-1551)Aat>Cat	p.N517H	SIGLEC10_ENST00000441969.3_Missense_Mutation_p.N459H|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.N554H|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.N427H|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.N469H|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.N434H|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.N612H|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.N612H|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.N369H	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	612					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GCTTTCTGATTCCGCTTCTGA	0.502000													23	63					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642599	57642599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57642599C>T	ENST00000254181.4	+	4	3010	c.2556C>T	c.(2554-2556)gcC>gcT	p.A852A	USP29_ENST00000598197.1_Silent_p.A852A	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	852					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGAAGCAGGCCTGGTTCACAT	0.468000													18	52					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83195246	83195246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:83195246C>T	ENST00000398309.2	-	17	2374	c.1904G>A	c.(1903-1905)aGc>aAc	p.S635N	DLG2_ENST00000376106.3_Intron|DLG2_ENST00000524982.1_Intron|DLG2_ENST00000532653.1_Intron|DLG2_ENST00000330014.6_Intron|DLG2_ENST00000543673.1_Missense_Mutation_p.S740N|DLG2_ENST00000376104.2_Missense_Mutation_p.S740N|DLG2_ENST00000280241.8_Missense_Mutation_p.S674N|DLG2_ENST00000531015.1_Missense_Mutation_p.S602N|DLG2_ENST00000537455.1_Intron|DLG2_ENST00000418306.2_Intron|DLG2_ENST00000426717.2_Intron|DLG2_ENST00000398304.1_Intron|DLG2_ENST00000404783.3_Intron	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	635						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				AAAGATGAAGCTCTTTTTACG	0.413000													30	97					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32800019	32800019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32800019C>T	ENST00000380250.3	+	39	5610	c.5114C>T	c.(5113-5115)tCc>tTc	p.S1705F		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AATTTCCATTCCATTGCTTCC	0.483000													47	90					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55340173	55340173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55340173C>T	ENST00000314634.3	+	1	570	c.570C>T	c.(568-570)acC>acT	p.T190T		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				GTTCAGAAACCTATGTGGTTA	0.433000													22	90					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205549800	205549800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205549800C>T	ENST00000367147.4	+	3	534	c.441C>T	c.(439-441)ttC>ttT	p.F147F	MFSD4_ENST00000539267.1_Silent_p.F147F|MFSD4_ENST00000536357.1_Intron	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	147					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TGCTCCATTTCTTCGTGGGCT	0.637000													15	168					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29429863	29429863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29429863G>A	ENST00000377136.1	+	4	782	c.317G>A	c.(316-318)gGg>gAg	p.G106E	OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377133.1_Missense_Mutation_p.G106E|OR2H1_ENST00000442615.1_Missense_Mutation_p.G106E|OR2H1_ENST00000396792.2_Missense_Mutation_p.G106E|OR2H1_ENST00000377132.1_Missense_Mutation_p.G106E			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						CTGTCCCTGGGGACCACTGAG	0.587000													41	103					0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109840830	109840830	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109840830C>G	ENST00000357155.1	-	2	244	c.195G>C	c.(193-195)cgG>cgC	p.R65R	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	65	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CCCCAACCTTCCGGATGTAGG	0.522000													24	126					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68882677	68882677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:68882677C>T	ENST00000303786.3	+	3	1571	c.1151C>T	c.(1150-1152)aCc>aTc	p.T384I	PROKR1_ENST00000394342.2_Missense_Mutation_p.T384I			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	384						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.T384N(1)		endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ATGCCTGCCACCGAAGAGGTG	0.483000													14	44					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15874868	15874868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15874868C>T	ENST00000375847.3	+	7	1132	c.968C>T	c.(967-969)gCc>gTc	p.A323V	DNAJC16_ENST00000375838.1_Missense_Mutation_p.A323V|DNAJC16_ENST00000375849.1_Missense_Mutation_p.A323V	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	323					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AATATCTACGCCCCTACCCTC	0.413000													17	57					0	0	1	0	0
TPTEP1	387590	broad.mit.edu	37	22	17119552	17119552	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17119552C>T	ENST00000426585.1	+	0	364																											CTTTATATTCCTTCGGAGTAT	0.348000													24	80					0	0	1	0	0
CAMK1D	57118	broad.mit.edu	37	10	12595318	12595318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:12595318G>A	ENST00000378847.3	+	2	524	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	CAMK1D_ENST00000378845.1_Missense_Mutation_p.E63K|CAMK1D_ENST00000487696.1_Intron	NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	63	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		GAAGGGCAAGGAAAGCAGCAT	0.542000													32	76					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4968027	4968027	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4968027G>A	ENST00000380373.2	-	1	329	c.304C>T	c.(304-306)Cag>Tag	p.Q102*	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGAATTCCTGGGCAAAGCAG	0.448000													59	140					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226080	23226080	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23226080G>A	ENST00000300061.2	+	12	1684	c.1541G>A	c.(1540-1542)aGa>aAa	p.R514K		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	514					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	CTGAACCAGAGATCCATCATG	0.502000													18	37					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43858077	43858077	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43858077G>A	ENST00000378009.4	+	0	167				CD177_ENST00000607517.1_RNA|CD177_ENST00000378012.2_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CCCCGGCAATGGACCCCTAAG	0.612000													33	64					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2164218	2164218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2164218G>A	ENST00000262304.4	-	11	3014	c.2806C>T	c.(2806-2808)Cgc>Tgc	p.R936C	PKD1_ENST00000423118.1_Missense_Mutation_p.R936C	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	936	PKD 4.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GGCGTGGCGCGGAGGCCACAG	0.697000													9	30					0	0	1	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119945434	119945434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:119945434G>A	ENST00000297350.4	-	2	514	c.136C>T	c.(136-138)Cct>Tct	p.P46S		NM_002546.3	NP_002537.3	O00300	TR11B_HUMAN	tumor necrosis factor receptor superfamily, member 11b	46					apoptosis|skeletal system development		cytokine activity|receptor activity			breast(1)|central_nervous_system(3)|endometrium(4)|large_intestine(6)|lung(7)|prostate(3)|skin(1)	25	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			TAGGTACCAGGAGGACATTTG	0.498000													57	235					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94944637	94944637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94944637C>T	ENST00000222381.3	-	4	598	c.367G>A	c.(367-369)Gaa>Aaa	p.E123K	PON1_ENST00000542556.1_Missense_Mutation_p.E123K	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	123					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TTGTTACCTTCATCTGTGAAT	0.303000													10	33					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36897018	36897018	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36897018G>A	ENST00000301807.6	-	12	4310	c.2413C>T	c.(2413-2415)Cag>Tag	p.Q805*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.Q1355*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.Q805*	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1355					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CTGATTTGCTGATACAGACTG	0.473000													36	122					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680148	114680148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114680148G>A	ENST00000393296.1	-	3	1117	c.1040C>T	c.(1039-1041)tCc>tTc	p.S347F	SYT6_ENST00000369547.1_Missense_Mutation_p.S262F			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	347					acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCCAGATGGAGGTTTCCCG	0.522000													33	66					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027464	55027464	+	Missense_Mutation	SNP	C	C	T	rs112730552	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:55027464C>T	ENST00000371336.3	+	5	1433	c.1232C>T	c.(1231-1233)tCc>tTc	p.S411F	CASS4_ENST00000360314.3_Missense_Mutation_p.S411F|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	411	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						AGCATCGTTTCCTCGTGCTCC	0.552000													15	26					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15843396	15843396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:15843396C>T	ENST00000217246.4	+	9	1047	c.652C>T	c.(652-654)Cgg>Tgg	p.R218W	MACROD2_ENST00000402914.1_5'UTR|MACROD2_ENST00000310348.4_Missense_Mutation_p.R218W	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	218	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CTAGGTGGATCGGATCATTTT	0.368000													11	43					0	0	1	0	0
RASGRP3	25780	broad.mit.edu	37	2	33783919	33783919	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33783919G>A	ENST00000403687.3	+	17	2626	c.1886G>A	c.(1885-1887)gGg>gAg	p.G629E	AC020594.5_ENST00000437680.1_RNA|RASGRP3_ENST00000407811.1_Missense_Mutation_p.G628E|RASGRP3_ENST00000402538.3_Missense_Mutation_p.G629E	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	629					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					GGGGACTCGGGGTCCCACACC	0.557000													20	73					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10312885	10312885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10312885G>A	ENST00000403437.2	-	16	1702	c.1608C>T	c.(1606-1608)atC>atT	p.I536I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	536	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CCTCTTCCAGGATGGAGAAGA	0.473000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				29	55					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088839	9088839	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9088839G>A	ENST00000397910.4	-	1	3179	c.2976C>T	c.(2974-2976)ctC>ctT	p.L992L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	992	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGTAGCAGAGAGAGAAGTGG	0.473000													76	221					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206610475	206610475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206610475C>T	ENST00000360409.3	+	10	2438	c.1647C>T	c.(1645-1647)ttC>ttT	p.F549F	NRP2_ENST00000540178.1_Silent_p.F549F|NRP2_ENST00000357785.5_Silent_p.F549F|NRP2_ENST00000412873.2_Silent_p.F549F|NRP2_ENST00000272849.3_Silent_p.F549F|NRP2_ENST00000540841.1_Silent_p.F549F|NRP2_ENST00000357118.4_Silent_p.F549F	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	549	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity	p.F549F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						TGCAGCTGTTCGAAGGGAACA	0.612000													12	28					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149508081	149508081	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149508081C>T	ENST00000378016.2	+	0	9475							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CACTGTGGTTCGTCCATGTGA	0.602000													6	49					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210977336	210977336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210977336G>A	ENST00000367007.4	-	8	1723	c.1554C>T	c.(1552-1554)tcC>tcT	p.S518S	KCNH1_ENST00000271751.4_Silent_p.S545S	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	545					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTCTGGACATGGACCAAGTGG	0.483000													39	113					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48416519	48416519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48416519G>A	ENST00000249598.1	-	1	334	c.175C>T	c.(175-177)Ctg>Ttg	p.L59L		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	59					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						ACGTTCTCCAGAAACATCTTC	0.607000													6	55					0	0	1	0	0
IFITM1	8519	broad.mit.edu	37	11	314350	314350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:314350C>T	ENST00000408968.3	+	1	498	c.180C>T	c.(178-180)tcC>tcT	p.S60S	IFITM1_ENST00000328221.5_Silent_p.S60S|IFITM1_ENST00000528780.1_Silent_p.S60S	NM_003641.3	NP_003632.3	P13164	IFM1_HUMAN	interferon induced transmembrane protein 1	60					negative regulation of cell proliferation|regulation of immune response|response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding|receptor signaling protein activity			large_intestine(1)|lung(3)	4		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		TCGCCTACTCCGTGAAGGTGC	0.622000													13	167					0	0	1	0	0
HMGB4	127540	broad.mit.edu	37	1	34329958	34329958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34329958G>A	ENST00000522796.1	+	4	2071	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K	CSMD2_ENST00000373381.4_Intron|HMGB4_ENST00000519684.1_Missense_Mutation_p.E56K|HMGB4_ENST00000425537.1_3'UTR			B2R4X7	B2R4X7_HUMAN	high mobility group box 4	56						nucleus	DNA binding			NS(1)|breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CTCAAAGCATGAAAAGGCCAA	0.423000													48	109					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870918	13870918	+	Silent	SNP	C	C	T	rs141079124		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13870918C>T	ENST00000265104.4	-	24	3896	c.3792G>A	c.(3790-3792)agG>agA	p.R1264R	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1264	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTTGCTCCTCCCTTATTTCTT	0.338000									Kartagener syndrome				15	59					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	313789	313789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:313789C>T	ENST00000428720.1	-	4	1033	c.290G>A	c.(289-291)gGc>gAc	p.G97D	RP11-283I3.2_ENST00000539568.1_RNA|SLC6A12_ENST00000424061.2_Missense_Mutation_p.G97D|SLC6A12_ENST00000536824.1_Missense_Mutation_p.G97D|SLC6A12_ENST00000397296.2_Missense_Mutation_p.G97D|SLC6A12_ENST00000359674.4_Missense_Mutation_p.G97D	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	97					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GGTGTATTGGCCCAACGCCAC	0.582000													17	48					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16980627	16980627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16980627C>T	ENST00000379803.1	+	14	2273	c.2259C>T	c.(2257-2259)gcC>gcT	p.A753A	SIN3B_ENST00000595541.1_Silent_p.A311A|SIN3B_ENST00000248054.5_Silent_p.A721A	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	753					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						ATGCCCCGGCCACTGAGCAGC	0.662000													19	41					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128477589	128477589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128477589C>T	ENST00000325888.8	+	4	1098	c.837C>T	c.(835-837)atC>atT	p.I279I	FLNC_ENST00000346177.6_Silent_p.I279I	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	279					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						AGAAAGCCATCGCCTATGGGC	0.597000													23	75					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66914311	66914311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66914311C>T	ENST00000269080.2	-	14	1941	c.1804G>A	c.(1804-1806)Gaa>Aaa	p.E602K	ABCA8_ENST00000586539.1_Missense_Mutation_p.E642K|ABCA8_ENST00000430352.2_Missense_Mutation_p.E642K	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	602	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GCAGTTGGTTCATCCAACAGG	0.403000													9	60					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57254689	57254689	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57254689G>A	ENST00000343433.6	-	3	956	c.876C>T	c.(874-876)gcC>gcT	p.A292A	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	292										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						GCCTCTGAAAGGCCTGGAGGT	0.587000													7	115					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149323976	149323976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149323976G>A	ENST00000255266.5	-	1	380	c.261C>T	c.(259-261)ttC>ttT	p.F87F		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	87	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CCTGCAGGAGGAAGCACAGCT	0.517000													6	63					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459983	107459983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107459983G>A	ENST00000409382.3	-	2	1061	c.451C>T	c.(451-453)Cct>Tct	p.P151S	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.P151S|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.P151S	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	151					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CCGGGGGAAGGGAATCCCAAT	0.607000													65	174					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432372	30432372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30432372C>T	ENST00000375978.3	-	1	1048	c.974G>A	c.(973-975)gGa>gAa	p.G325E		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	325					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.G325E(1)		kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						GAAGAACATTCCTGGCGTCCG	0.617000													28	79					0	0	1	0	0
TMEM183A	92703	broad.mit.edu	37	1	202991991	202991991	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202991991C>T	ENST00000367242.3	+	8	1034	c.954C>T	c.(952-954)atC>atT	p.I318I		NM_001079809.1|NM_138391.4	NP_001073277.1|NP_612400.3			transmembrane protein 183A											endometrium(1)|large_intestine(2)|lung(1)|skin(3)	7			BRCA - Breast invasive adenocarcinoma(75;0.18)			AGTTTACTATCAATGTGAGCA	0.448000													59	158					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227922301	227922301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227922301G>A	ENST00000396625.3	-	29	2606	c.2399C>T	c.(2398-2400)cCt>cTt	p.P800L	COL4A4_ENST00000329662.7_Missense_Mutation_p.P800L	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	800	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TAGGAATCCAGGAATGCCAGC	0.478000													11	31					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36118737	36118737	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36118737C>A	ENST00000303965.4	-	25	4473	c.3984G>T	c.(3982-3984)ttG>ttT	p.L1328F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1328	Ras-associating.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTTCAATTAACAAATCTCCAG	0.363000													7	34					0.00198382	0.00198545	1	1	0
FAM120C	54954	broad.mit.edu	37	X	54184166	54184166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54184166G>A	ENST00000375180.2	-	3	1041	c.985C>T	c.(985-987)Cac>Tac	p.H329Y	FAM120C_ENST00000328235.4_Missense_Mutation_p.H329Y	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	329										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						AGGCTCCAGTGAAAAGCAGCC	0.423000													10	9					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17411114	17411114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17411114G>A	ENST00000375486.4	-	8	981	c.918C>T	c.(916-918)ccC>ccT	p.P306P	PADI2_ENST00000375481.1_Silent_p.P306P|PADI2_ENST00000444885.2_Intron	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	306					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ACACCGACACGGGAGGCAGGA	0.587000													2	2					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626236	140626236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140626236G>A	ENST00000231173.3	+	1	1090	c.1090G>A	c.(1090-1092)Gaa>Aaa	p.E364K		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		364	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCAGAGACAGAAGTGGCCCT	0.423000													25	99					0	0	1	0	0
GBP3	2635	broad.mit.edu	37	1	89477649	89477649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89477649C>T	ENST00000370481.4	-	7	1150	c.930G>A	c.(928-930)atG>atA	p.M310I		NM_018284.2	NP_060754.2	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	310						integral to membrane	GTP binding|GTPase activity			breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		CTGCGTTCTCCATGCAGGGCA	0.498000													27	49					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84510501	84510501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84510501G>A	ENST00000360700.4	+	4	1202	c.316G>A	c.(316-318)Gaa>Aaa	p.E106K	ZNF711_ENST00000373165.3_Missense_Mutation_p.E106K|ZNF711_ENST00000276123.3_Missense_Mutation_p.E106K|ZNF711_ENST00000395402.1_Missense_Mutation_p.E84K			Q9Y462	ZN711_HUMAN	zinc finger protein 711	106					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GGATTTAGAGGAAGATGATGG	0.438000													63	48					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74004305	74004305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74004305C>T	ENST00000301607.3	-	22	5234	c.4981G>A	c.(4981-4983)Gac>Aac	p.D1661N	EVPL_ENST00000586740.1_Missense_Mutation_p.D1683N	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1661	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCGTGGAGGTCCCGGAGCGTC	0.672000													25	63					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146350703	146350703	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:146350703C>T	ENST00000392299.2	+	2	520	c.50C>T	c.(49-51)tCc>tTc	p.S17F	GRM1_ENST00000507907.1_Missense_Mutation_p.S17F|GRM1_ENST00000282753.1_Missense_Mutation_p.S17F|GRM1_ENST00000355289.4_Missense_Mutation_p.S17F|GRM1_ENST00000361719.2_Missense_Mutation_p.S17F|GRM1_ENST00000492807.2_Missense_Mutation_p.S17F			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	17					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTGGAGGTGTCCCTTCTCCCC	0.602000													99	114					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41153949	41153949	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41153949C>T	ENST00000263413.3	-	15	2517	c.2253G>A	c.(2251-2253)tgG>tgA	p.W751*	C6_ENST00000337836.5_Nonsense_Mutation_p.W751*	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	751	C5b-binding domain.|Sushi 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGGGTGGTGTCCAGGAATTCC	0.473000													9	64					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148963692	148963692	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148963692C>T	ENST00000434415.1	+	2	454	c.291C>T	c.(289-291)gcC>gcT	p.A97A		NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	97					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GCAAGTGGGCCGTGCTGGGGA	0.632000													29	99					0	0	1	0	0
NKD1	85407	broad.mit.edu	37	16	50667106	50667106	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50667106C>T	ENST00000268459.3	+	10	1051	c.827C>T	c.(826-828)tCc>tTc	p.S276F		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	276					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		TTCCTAGGCTCCCCTTCCGTG	0.582000													25	55					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114290179	114290179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114290179G>A	ENST00000374374.3	+	2	679	c.504G>A	c.(502-504)gaG>gaA	p.E168E	ZNF483_ENST00000358151.4_Intron|ZNF483_ENST00000309235.5_Intron|ZNF483_ENST00000355824.3_Intron			Q8TF39	ZN483_HUMAN	zinc finger protein 483	104					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						CTGCTAAAGaggagtctgagg	0.408000													7	8					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606482	55606482	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55606482G>A	ENST00000378396.1	+	1	255	c.255G>A	c.(253-255)gtG>gtA	p.V85V		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TGATGCTGGTGAACCTGGTTG	0.393000													107	240					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15326031	15326031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15326031G>A	ENST00000378116.4	-	2	177	c.171C>T	c.(169-171)ttC>ttT	p.F57F		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	57						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CCTGGTTGGTGAAGATCTCGA	0.552000													22	48					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013381	107013381	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107013381C>T	ENST00000390625.2	-	0	96																											GAAAACCCAGCTAAGCCCAAA	0.493000													36	200					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25718682	25718682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:25718682G>A	ENST00000520164.1	-	13	1762	c.1225C>T	c.(1225-1227)Ccc>Tcc	p.P409S	EBF2_ENST00000535548.1_Missense_Mutation_p.P140S|EBF2_ENST00000408929.3_Missense_Mutation_p.P261S	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	409					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		AGCTGGCTGGGATTCCTGGGG	0.527000													39	90					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61557841	61557841	+	Missense_Mutation	SNP	G	G	A	rs149412997	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61557841G>A	ENST00000290866.4	+	5	823	c.799G>A	c.(799-801)Gga>Aga	p.G267R	ACE_ENST00000538928.1_Missense_Mutation_p.G267R|ACE_ENST00000428043.1_Missense_Mutation_p.G267R|ACE_ENST00000584529.1_3'UTR	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	267	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TCGCCGATACGGAGACAGATA	0.607000													34	87					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57672040	57672040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57672040C>T	ENST00000554048.2	-	2	150	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	51						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		GTATTGATTTCTAAAGCAAGT	0.393000													28	100					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117552834	117552834	+	Silent	SNP	G	G	A	rs142354033		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117552834G>A	ENST00000374045.4	-	4	767	c.654C>T	c.(652-654)ttC>ttT	p.F218F	TNFSF15_ENST00000374044.1_Silent_p.F141F	NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	218					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						CTTGCAAGGAGAACATGGCTC	0.488000													16	82					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39755530	39755530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39755530G>A	ENST00000442448.1	-	11	1455	c.1184C>T	c.(1183-1185)cCc>cTc	p.P395L	ERG_ENST00000398910.1_Missense_Mutation_p.P396L|ERG_ENST00000398911.1_Missense_Mutation_p.P395L|ERG_ENST00000398905.1_Missense_Mutation_p.P388L|ERG_ENST00000417133.2_Missense_Mutation_p.P419L|ERG_ENST00000288319.7_Missense_Mutation_p.P412L|ERG_ENST00000398897.1_Missense_Mutation_p.P296L|ERG_ENST00000453032.2_Missense_Mutation_p.P320L|ERG_ENST00000398919.2_Missense_Mutation_p.P419L|ERG_ENST00000398907.1_Missense_Mutation_p.P389L	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	419					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				GAGGTCTGAGGGGTACTTGTA	0.607000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								24	80					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48602929	48602929	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48602929C>T	ENST00000328333.8	-	115	8548	c.8440_splice	c.e115-1	p.R2814_splice	COL7A1_ENST00000454817.1_Splice_Site_p.R2782_splice	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2814	Nonhelical region (NC2).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGGAGGGGTCCTGGAGCCAA	0.642000													8	16					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52547965	52547965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52547965C>T	ENST00000321725.6	+	32	3491	c.3415C>T	c.(3415-3417)Cct>Tct	p.P1139S		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1139	FAS1 4.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGACTTGGTGCCTGCCTTCAG	0.642000													53	121					0	0	1	0	0
VIPAS39	63894	broad.mit.edu	37	14	77910637	77910637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77910637G>A	ENST00000553888.1	-	8	1062	c.552C>T	c.(550-552)ctC>ctT	p.L184L	VIPAS39_ENST00000557658.1_Silent_p.L184L|VIPAS39_ENST00000556412.1_Silent_p.L210L|VIPAS39_ENST00000448935.2_Silent_p.L135L|VIPAS39_ENST00000327028.4_Silent_p.L171L|VIPAS39_ENST00000343765.2_Silent_p.L184L	NM_001193314.1|NM_001193317.1|NM_022067.3	NP_001180243.1|NP_001180246.1|NP_071350.2			VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog																		CCTCTTCTAGGAGTTGTAGTT	0.383000													21	56					0	0	1	0	0
TET2	54790	broad.mit.edu	37	4	106155412	106155412	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:106155412G>A	ENST00000540549.1	+	3	1173	c.313G>A	c.(313-315)Ggg>Agg	p.G105R	TET2_ENST00000413648.2_Missense_Mutation_p.G105R|TET2_ENST00000394764.1_Missense_Mutation_p.G105R|TET2_ENST00000545826.1_Missense_Mutation_p.G105R|TET2_ENST00000513237.1_Missense_Mutation_p.G126R|TET2_ENST00000305737.2_Missense_Mutation_p.G105R|TET2_ENST00000380013.4_Missense_Mutation_p.G105R			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	105					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TTCTCTCTCTGGGCTCCTTCA	0.423000			"""Mis N, F"""		MDS								26	53					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220355492	220355492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220355492G>A	ENST00000312358.7	+	38	9331	c.9199G>A	c.(9199-9201)Gtg>Atg	p.V3067M	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	3067	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CACTTACATGGTGCAGCTGCT	0.602000													26	79					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82785261	82785261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82785261C>T	ENST00000423517.2	-	2	1033	c.696G>A	c.(694-696)caG>caA	p.Q232Q	PCLO_ENST00000333891.8_Silent_p.Q232Q	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	232	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GAGTGCCATCCTGCTGAAGCG	0.468000													17	31					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54776454	54776454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54776454C>T	ENST00000218436.6	-	13	3845	c.3816G>A	c.(3814-3816)gtG>gtA	p.V1272V		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1272					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TGCCTAGAATCACAGGCACAT	0.602000													17	5					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47363609	47363609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47363609C>T	ENST00000545968.1	-	18	1777	c.1723G>A	c.(1723-1725)Ggt>Agt	p.G575S	MYBPC3_ENST00000256993.4_Missense_Mutation_p.G574S|MYBPC3_ENST00000399249.2_Missense_Mutation_p.G575S	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	574	Ig-like C2-type 4.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		AGCCACACACCCCGAACATTC	0.577000													8	15					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46143848	46143848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46143848G>A	ENST00000374366.3	-	6	706	c.241C>T	c.(241-243)Cct>Tct	p.P81S	ZFAND4_ENST00000374370.1_5'UTR|ZFAND4_ENST00000374371.2_Missense_Mutation_p.P155S|ZFAND4_ENST00000344646.5_Missense_Mutation_p.P155S			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	155	Ubiquitin-like.						zinc ion binding										TCTACTGCAGGAAAGAAATTC	0.413000													20	162					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55195914	55195914	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:55195914G>A	ENST00000396834.1	+	10	1462	c.966G>A	c.(964-966)ggG>ggA	p.G322G	IL31RA_ENST00000297015.3_Silent_p.G199G|IL31RA_ENST00000396836.2_Silent_p.G341G|IL31RA_ENST00000354961.4_Silent_p.G322G|IL31RA_ENST00000447346.2_Silent_p.G341G|IL31RA_ENST00000359040.5_Silent_p.G341G|IL31RA_ENST00000490985.1_Silent_p.G199G	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	309	Fibronectin type-III 4.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ATTCTCTTGGGAAGTCTCCAG	0.453000													20	194					0	0	1	0	0
THBD	7056	broad.mit.edu	37	20	23029230	23029230	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23029230G>A	ENST00000377103.2	-	1	1148	c.912C>T	c.(910-912)ggC>ggT	p.G304G		NM_000361.2	NP_000352.1	P07204	TRBM_HUMAN	thrombomodulin	304	EGF-like 2.				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity			endometrium(2)|large_intestine(3)|ovary(1)|skin(1)	7	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	ACGAGTAGGAGCCCGGCTGGT	0.687000													8	15					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39265290	39265290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39265290C>T	ENST00000280481.7	+	1	4025	c.3809C>T	c.(3808-3810)tCc>tTc	p.S1270F		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1270					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CATGATGACTCCGAGACCCAG	0.428000													110	250					0	0	1	0	0
RTP3	83597	broad.mit.edu	37	3	46541948	46541948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46541948G>A	ENST00000296142.3	+	2	830	c.258G>A	c.(256-258)atG>atA	p.M86I		NM_031440.1	NP_113628.1	Q9BQQ7	RTP3_HUMAN	receptor (chemosensory) transporter protein 3	86					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			endometrium(1)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		AGGTGAAGATGAGGGTGTTTA	0.522000													13	187					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130287	45130287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45130287C>T	ENST00000457685.2	-	6	2900	c.1577G>A	c.(1576-1578)aGa>aAa	p.R526K	ZNF334_ENST00000593880.1_Missense_Mutation_p.R587K|ZNF334_ENST00000347606.4_Missense_Mutation_p.R564K			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TGTGTGTGTTCTCTGATGGTG	0.463000													59	156					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439392	150439392	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150439392C>T	ENST00000358647.3	+	3	532	c.165C>T	c.(163-165)tcC>tcT	p.S55S	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGTTTGAGTCCAAGCTGAGGG	0.562000													27	62					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31743882	31743882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:31743882G>A	ENST00000396556.2	-	7	1336	c.1214C>T	c.(1213-1215)tCa>tTa	p.S405L	OSBPL10_ENST00000438237.2_Missense_Mutation_p.S341L	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	405					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		TTTGAGTTGTGAAATGAGATG	0.428000													13	58					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15487565	15487565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:15487565G>A	ENST00000341776.2	+	6	942	c.698G>A	c.(697-699)cGg>cAg	p.R233Q	JARID2_ENST00000397311.3_Missense_Mutation_p.R61Q|JARID2_ENST00000541660.1_Missense_Mutation_p.R195Q	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	233					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGGTCAACACGGGAGAAGGAA	0.493000													15	40					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327124	52327124	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52327124C>T	ENST00000339223.4	+	2	302	c.123C>T	c.(121-123)gtC>gtT	p.V41V	FPR3_ENST00000595991.1_Silent_p.V41V	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	41					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TCTTCGGGGTCCTGGGCAATG	0.547000													27	77					0	0	1	0	0
P2RX3	5024	broad.mit.edu	37	11	57135874	57135874	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57135874C>T	ENST00000263314.2	+	10	1000	c.966C>T	c.(964-966)atC>atT	p.I322I		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	322					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						TCCCCACCATCATCAGCTCTG	0.622000													43	162					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196642613	196642613	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196642613G>A	ENST00000312428.6	-	59	11075	c.10975C>T	c.(10975-10977)Cta>Tta	p.L3659L	DNAH7_ENST00000409063.1_Silent_p.L142L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3659					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATTTGTTTAGAATGCTGCGC	0.473000													23	60					0	0	1	0	0
MARS2	92935	broad.mit.edu	37	2	198570227	198570227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:198570227C>T	ENST00000282276.6	+	1	141	c.98C>T	c.(97-99)tCc>tTc	p.S33F	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	33					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	AGTTCGGGCTCCCTCAGTGCC	0.622000													17	60					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38652442	38652442	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:38652442C>T	ENST00000494540.1	+	0	432					NR_003086.1																						TTCATATGTTCTCCACAGCTG	0.428000													15	39					0	0	1	0	0
KAZALD1	81621	broad.mit.edu	37	10	102822738	102822738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102822738C>T	ENST00000370200.5	+	2	715	c.389C>T	c.(388-390)tCg>tTg	p.S130L		NM_030929.4	NP_112191.2	Q96I82	KAZD1_HUMAN	Kazal-type serine peptidase inhibitor domain 1	130	Kazal-like.				cell differentiation|multicellular organismal development|ossification|regulation of cell growth		insulin-like growth factor binding			endometrium(1)|ovary(1)|prostate(2)	4				Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		GCCTGTCGTTCGCAGAGTCCG	0.687000													8	21					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573729	38573729	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38573729C>T	ENST00000222345.6	+	3	2033	c.1524C>T	c.(1522-1524)ttC>ttT	p.F508F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	508					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGATTACTTCGTGGGCAAAG	0.622000													22	30					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36330466	36330466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36330466G>A	ENST00000378910.5	-	21	2858	c.2859C>T	c.(2857-2859)acC>acT	p.T953T	NPHS1_ENST00000353632.6_Silent_p.T953T	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	953	Fibronectin type-III.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGGAGTGTGGGGTCAGACTCA	0.557000													21	98					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781919	128781919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128781919C>T	ENST00000529694.1	+	2	1127	c.751C>T	c.(751-753)Ccc>Tcc	p.P251S	KCNJ5_ENST00000338350.4_Missense_Mutation_p.P251S|KCNJ5_ENST00000533599.1_Missense_Mutation_p.P251S	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	251					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	GGAGTTCATCCCCCTGAACCA	0.592000													42	106					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167666583	167666583	+	Missense_Mutation	SNP	G	G	A	rs142342977	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167666583G>A	ENST00000367854.3	+	6	1053	c.722G>A	c.(721-723)aGg>aAg	p.R241K	RCSD1_ENST00000537350.1_Missense_Mutation_p.R211K	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	241	RCSD.									NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CCTCTGAGGAGGTCACCCAGC	0.617000													13	31					0	0	1	0	0
CTRB1	1504	broad.mit.edu	37	16	75258657	75258657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:75258657G>A	ENST00000361017.4	+	7	693	c.685G>A	c.(685-687)Ggc>Agc	p.G229S		NM_001906.4	NP_001897.4			chymotrypsinogen B1											central_nervous_system(1)|lung(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.166)		GACCCTGGTGGGCATTGTGTC	0.647000													19	72					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760756	92760756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92760756C>T	ENST00000318238.4	-	5	5745	c.4529G>A	c.(4528-4530)gGg>gAg	p.G1510E	SAMD9L_ENST00000411955.1_Missense_Mutation_p.G1510E|SAMD9L_ENST00000437805.1_Missense_Mutation_p.G1510E	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1510										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CCACACATCCCCACTGTGCCA	0.418000													41	85					0	0	1	0	0
PRRT2	112476	broad.mit.edu	37	16	29824855	29824855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29824855C>T	ENST00000300797.6	+	2	654	c.480C>T	c.(478-480)ctC>ctT	p.L160L	PRRT2_ENST00000567659.1_Silent_p.L160L|PRRT2_ENST00000567551.1_Intron|PRRT2_ENST00000358758.7_Silent_p.L160L|AC009133.20_ENST00000569039.1_RNA			Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	160	Pro-rich.				response to biotic stimulus	integral to membrane				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						AACCAGAGCTCCCTACCCAGG	0.632000													12	28					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8687402	8687402	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8687402G>A	ENST00000299663.3	-	6	657	c.492C>T	c.(490-492)ttC>ttT	p.F164F	CLEC4E_ENST00000545274.1_Silent_p.F119F|CLEC4E_ENST00000446457.2_3'UTR	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	164	C-type lectin.					integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					CTACATCCCAGAAGCTGAAAA	0.408000													20	53					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38230307	38230307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38230307C>T	ENST00000339503.4	-	8	1411	c.910G>A	c.(910-912)Gag>Aag	p.E304K	ZNF573_ENST00000536220.1_Missense_Mutation_p.E274K|ZNF573_ENST00000392138.1_Missense_Mutation_p.E275K|ZNF573_ENST00000357309.3_Missense_Mutation_p.E274K|ZNF573_ENST00000590414.2_Missense_Mutation_p.E362K	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TTCTTACACTCCTTACATTCA	0.378000													23	94					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42263150	42263150	+	Missense_Mutation	SNP	C	C	T	rs150623766		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42263150C>T	ENST00000361204.4	+	2	570	c.404C>T	c.(403-405)cCc>cTc	p.P135L		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	135	Gln-rich.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						cagccccgcccccagccccag	0.597000													38	71					0	0	1	0	0
SMOC2	64094	broad.mit.edu	37	6	168910679	168910679	+	Missense_Mutation	SNP	G	G	C	rs144833047		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:168910679G>C	ENST00000354536.5	+	2	389	c.169G>C	c.(169-171)Gga>Cga	p.G57R	SMOC2_ENST00000356284.2_Missense_Mutation_p.G57R	NM_022138.2	NP_071421.1	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	57	Kazal-like.				signal transduction	basement membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	32		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CGCATCTGACGGAAGGACCTT	0.463000													38	37					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54420804	54420804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54420804G>A	ENST00000296733.1	-	9	1216	c.1042C>T	c.(1042-1044)Cat>Tat	p.H348Y	CDC20B_ENST00000322374.6_Missense_Mutation_p.H348Y|CDC20B_ENST00000334206.5_3'UTR|CDC20B_ENST00000381375.2_Missense_Mutation_p.H348Y	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	348										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			GTTCCAACATGATGCTGGGCT	0.498000													35	75					0	0	1	0	0
RBM19	9904	broad.mit.edu	37	12	114386804	114386804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:114386804G>A	ENST00000545145.2	-	10	1188	c.1110C>T	c.(1108-1110)gtC>gtT	p.V370V	RBM19_ENST00000392561.3_Silent_p.V370V|RBM19_ENST00000261741.5_Silent_p.V370V	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	370					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TGGTGGTGGGGACGTTCTTTT	0.587000													21	168					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49706729	49706729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:49706729C>T	ENST00000303221.5	-	4	669	c.454G>A	c.(454-456)Gga>Aga	p.G152R	EMB_ENST00000508934.1_Missense_Mutation_p.G98R|EMB_ENST00000514111.1_Missense_Mutation_p.G102R|EMB_ENST00000506190.1_5'UTR	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	152	Ig-like V-type 1.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TTAAATGTTCCCCTTTGTTCC	0.284000													4	51					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38802355	38802355	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38802355G>A	ENST00000359357.3	+	30	3906	c.3651_splice	c.e30-1	p.E1218_splice	DNAH8_ENST00000449981.2_Splice_Site_p.E1435_splice|DNAH8_ENST00000441566.1_Splice_Site_p.E1218_splice					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTCCTTACAGGAAGGACCTAT	0.323000													39	105					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	654295	654295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:654295G>A	ENST00000255622.6	+	12	1550	c.1507G>A	c.(1507-1509)Gaa>Aaa	p.E503K	PDE6B_ENST00000429163.2_Missense_Mutation_p.E224K|PDE6B_ENST00000496514.1_Missense_Mutation_p.E503K	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	503					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						TGACATCTACGAATTCCACTT	0.572000													7	38					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175355212	175355212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175355212C>T	ENST00000367674.1	-	8	2441	c.1733G>A	c.(1732-1734)cGa>cAa	p.R578Q	TNR_ENST00000263525.2_Missense_Mutation_p.R578Q	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	578	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GTTGGTCCCTCGGACGGCACT	0.637000													40	104					0	0	1	0	0
CDK18	5129	broad.mit.edu	37	1	205498689	205498689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205498689C>T	ENST00000360066.2	+	13	1520	c.1219C>T	c.(1219-1221)Ctg>Ttg	p.L407L	CDK18_ENST00000429964.2_Silent_p.L407L|CDK18_ENST00000506784.1_Silent_p.L437L|CDK18_ENST00000509056.1_3'UTR	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	405	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						CAGCCTGCTCCTGGTGAGTGT	0.667000													12	44					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48338023	48338023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48338023C>T	ENST00000435803.1	+	23	9284	c.9260C>T	c.(9259-9261)tCc>tTc	p.S3087F		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3087					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CTTCGCTCTTCCATCCAAATC	0.368000													23	32					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179504001	179504001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179504001G>A	ENST00000367618.3	+	25	3322	c.2935G>A	c.(2935-2937)Gaa>Aaa	p.E979K		NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	979	Glu-rich.									NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						agaagagaaagaaaatcaaga	0.323000													8	71					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227191	38227191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38227191C>T	ENST00000373048.4	-	3	735	c.736G>A	c.(736-738)Ggg>Agg	p.G246R	EPHA10_ENST00000427468.2_Missense_Mutation_p.G246R|EPHA10_ENST00000319637.6_Missense_Mutation_p.G246R	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	246						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCAGGCTCCCCTTCCGAGTGC	0.731000													4	31					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77702315	77702315	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:77702315G>A	ENST00000534064.1	-	2	119	c.85C>T	c.(85-87)Cga>Tga	p.R29*	INTS4_ENST00000527522.1_Nonsense_Mutation_p.R29*|INTS4_ENST00000529807.1_Nonsense_Mutation_p.R29*	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	29					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TTTGTTAGTCGGAGTTTCTTA	0.428000													44	97					0	0	1	0	0
SUN5	140732	broad.mit.edu	37	20	31577468	31577468	+	Missense_Mutation	SNP	C	C	T	rs142997193		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31577468C>T	ENST00000356173.3	-	9	663	c.571G>A	c.(571-573)Gga>Aga	p.G191R	SUN5_ENST00000375523.3_Missense_Mutation_p.G166R	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	191					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						ATGTAATCTCCGTGTATCATC	0.488000													13	57					0	0	1	0	0
FAM227B	196951	broad.mit.edu	37	15	49800440	49800440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:49800440C>T	ENST00000299338.6	-	11	1283	c.980G>A	c.(979-981)aGa>aAa	p.R327K	FAM227B_ENST00000561064.1_Missense_Mutation_p.R293K	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		GTCTGCAATTCTTTCCTTTAC	0.348000													8	123					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40762483	40762483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40762483C>T	ENST00000216194.7	+	13	1468	c.1412C>T	c.(1411-1413)cCa>cTa	p.P471L	RP5-1042K10.13_ENST00000498234.1_RNA|ADSL_ENST00000342312.6_Missense_Mutation_p.P412L|ADSL_ENST00000454266.2_Missense_Mutation_p.P485L	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	471					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						CTGTTAAAACCATATGAAAGC	0.358000													22	49					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100085	110100085	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110100085C>T	ENST00000518632.1	+	2	695	c.344C>T	c.(343-345)tCa>tTa	p.S115L	TRHR_ENST00000311762.2_Missense_Mutation_p.S115L			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	115						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			TCCTCTTGTTCAATAACAGCC	0.413000													22	60					0	0	1	0	0
SEC1P	653677	broad.mit.edu	37	19	49183689	49183689	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49183689C>T	ENST00000430145.2	+	0	776					NR_004401.2																						CCGCCACATCCCGGGGCGCTG	0.652000													13	36					0	0	1	0	0
SNTB1	6641	broad.mit.edu	37	8	121561077	121561077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121561077C>T	ENST00000395601.3	-	6	1672	c.1258G>A	c.(1258-1260)Gac>Aac	p.D420N	SNTB1_ENST00000517992.1_Missense_Mutation_p.D420N	NM_021021.3	NP_066301.1	Q13884	SNTB1_HUMAN	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	420	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(6)	24	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			TGGGAGAGGTCCCTGCTGGTC	0.522000													16	61					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72368614	72368614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72368614C>T	ENST00000335666.4	+	4	1312	c.1264C>T	c.(1264-1266)Cgg>Tgg	p.R422W		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	422						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CAAGACTTTCCGGGCCACTGT	0.617000													25	60					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113783888	113783888	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:113783888G>A	ENST00000375559.3	+	2	231	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	F10_ENST00000409306.1_Missense_Mutation_p.E65K|F10_ENST00000483537.1_3'UTR|F10_ENST00000375551.3_Missense_Mutation_p.E65K	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	65	Gla.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGCTCATACGAAGAGGCCCG	0.572000													31	91					0	0	1	0	0
OR13J1	392309	broad.mit.edu	37	9	35870088	35870088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35870088C>T	ENST00000377981.2	-	1	373	c.311G>A	c.(310-312)aGc>aAc	p.S104N		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			CGTGGACAGGCTCAGACACAT	0.597000													7	44					0	0	1	0	0
ZNF16	7564	broad.mit.edu	37	8	146156154	146156154	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:146156154G>A	ENST00000276816.4	-	4	2205	c.2019C>T	c.(2017-2019)atC>atT	p.I673I	ZNF16_ENST00000394909.2_Silent_p.I673I	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	673					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		ACTGGTGTTTGATCAACTTTG	0.527000													35	166					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41318367	41318367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41318367C>T	ENST00000551295.2	+	6	526	c.409C>T	c.(409-411)Cct>Tct	p.P137S	CNTN1_ENST00000360099.3_Missense_Mutation_p.P137S|CNTN1_ENST00000547702.1_Missense_Mutation_p.P137S|CNTN1_ENST00000347616.1_Missense_Mutation_p.P137S|CNTN1_ENST00000348761.2_Missense_Mutation_p.P126S|CNTN1_ENST00000547849.1_Missense_Mutation_p.P137S	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	137	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AGATCTTGATCCTTTCCCACC	0.388000													9	20					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152086448	152086448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152086448G>A	ENST00000368804.1	-	1	108	c.109C>T	c.(109-111)Ctt>Ttt	p.L37F		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	37	EF-hand 1.|S-100-like.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCCTTTCAAGGAGGTTCTTC	0.403000													21	125					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38934840	38934840	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38934840G>A	ENST00000355481.4	+	6	607	c.476G>A	c.(475-477)gGa>gAa	p.G159E	RYR1_ENST00000360985.3_Missense_Mutation_p.G159E|RYR1_ENST00000359596.3_Missense_Mutation_p.G159E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	159	MIR 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGGTCTGAAGGAGAAAAGGTC	0.602000													26	46					0	0	1	0	0
OR10G8	219869	broad.mit.edu	37	11	123901221	123901221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123901221C>T	ENST00000431524.1	+	1	925	c.892C>T	c.(892-894)Ctg>Ttg	p.L298L		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GAAGAAAGCTCTGTTGAAGCT	0.448000													39	78					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18648044	18648044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18648044G>A	ENST00000308799.4	+	1	706	c.487G>A	c.(487-489)Gag>Aag	p.E163K	FBXW10_ENST00000395665.4_Missense_Mutation_p.E163K|FBXW10_ENST00000301938.4_Missense_Mutation_p.E163K|FBXW10_ENST00000395667.1_Missense_Mutation_p.E163K			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	163										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						GTTTCTGAGAGAGGAGAACAA	0.493000													12	34					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143096028	143096028	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143096028C>T	ENST00000275815.3	-	6	1088	c.1002G>A	c.(1000-1002)tcG>tcA	p.S334S		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	334	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TTCGGGGGGCCGAGGGGGGAC	0.632000													6	13					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176946975	176946975	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:176946975C>T	ENST00000308618.4	-	2	766	c.630G>A	c.(628-630)gaG>gaA	p.E210E		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	210						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		ACACATAGTTCTCCCGGTAGA	0.662000													9	19					0	0	1	0	0
GBP7	388646	broad.mit.edu	37	1	89618454	89618454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89618454G>A	ENST00000294671.2	-	4	463	c.325C>T	c.(325-327)Cct>Tct	p.P109S		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	109						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TCACTCTTAGGGTCACTCTAG	0.443000													5	58					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181680128	181680128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181680128G>A	ENST00000526775.1	+	8	1259	c.1094G>A	c.(1093-1095)aGg>aAg	p.R365K	CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R316K|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R365K|CACNA1E_ENST00000360108.3_Missense_Mutation_p.R365K|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R365K|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R316K	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	365					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GAGAACCGAAGGGCTTTCATG	0.547000													28	91					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897995	175897995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175897995G>A	ENST00000359240.3	+	5	1989	c.1319G>A	c.(1318-1320)gGg>gAg	p.G440E	ADAM29_ENST00000404450.4_Missense_Mutation_p.G440E|ADAM29_ENST00000445694.1_Missense_Mutation_p.G440E|ADAM29_ENST00000514159.1_Missense_Mutation_p.G440E	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	440	Disintegrin.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGTGCTTTTGGGCTTTGTTGC	0.448000													16	83					0	0	1	0	0
C9orf9	11092	broad.mit.edu	37	9	135759459	135759459	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135759459C>G	ENST00000372136.3	+	2	572	c.125C>G	c.(124-126)cCc>cGc	p.P42R	C9orf9_ENST00000356311.5_Missense_Mutation_p.P42R|C9orf9_ENST00000350499.6_Missense_Mutation_p.P42R			Q96E40	CI009_HUMAN	chromosome 9 open reading frame 9	42								p.?(1)		cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		AAGATCCGGCCCATCTCCAGC	0.637000													7	53					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94502338	94502338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94502338G>A	ENST00000370225.3	-	26	3906	c.3820C>T	c.(3820-3822)Ctg>Ttg	p.L1274L		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1274					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GTGACCTTCAGAAAAATCTGT	0.428000													24	153					0	0	1	0	0
ZNF841	284371	broad.mit.edu	37	19	52569401	52569401	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52569401G>A	ENST00000389534.4	-	7	2193	c.1734C>T	c.(1732-1734)ttC>ttT	p.F578F	ZNF841_ENST00000594295.1_Silent_p.F578F|ZNF841_ENST00000359973.2_Intron|ZNF841_ENST00000426391.2_Silent_p.F462F|ZNF432_ENST00000598446.1_Intron	NM_001136499.1	NP_001129971.1	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|lung(3)	11						AATAGTAAGTGAAGACCATGC	0.418000													19	82					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84118695	84118695	+	Silent	SNP	G	G	A	rs141095084	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84118695G>A	ENST00000343411.3	-	10	1674	c.1179C>T	c.(1177-1179)acC>acT	p.T393T	MBTPS1_ENST00000569770.1_5'UTR	NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	393	Serine protease.				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CAGCACCATAGGTGACAATGT	0.567000											OREG0023982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	63					0	0	1	0	0
C19orf55	148137	broad.mit.edu	37	19	36255969	36255969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36255969C>T	ENST00000544099.1	+	7	724	c.661C>T	c.(661-663)Ccc>Tcc	p.P221S	C19orf55_ENST00000396908.4_Missense_Mutation_p.P221S			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	221	Ser-rich.									cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCCCTCAGCCCCAGCGATGC	0.627000													56	213					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55045177	55045177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55045177G>A	ENST00000335056.3	+	3	335	c.297G>A	c.(295-297)aaG>aaA	p.K99K																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GAATTTACAAGCACGCCTCAA	0.552000													7	34					0	0	1	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337365	22337365	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22337365C>T	ENST00000390436.2	+	0	179																											CAAACTACTTCCCTTGGTATA	0.438000													56	140					0	0	1	0	0
RASA2	5922	broad.mit.edu	37	3	141295889	141295889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141295889C>T	ENST00000286364.3	+	15	1566	c.1531C>T	c.(1531-1533)Cgt>Tgt	p.R511C	RASA2_ENST00000452898.1_Missense_Mutation_p.R511C			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	511	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						TGTATTTCTTCGTTTCTTTGC	0.358000													53	136					0	0	1	0	0
MRE11A	4361	broad.mit.edu	37	11	94180480	94180480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94180480G>A	ENST00000323929.3	-	15	1910	c.1688C>T	c.(1687-1689)tCa>tTa	p.S563L	MRE11A_ENST00000407439.3_Missense_Mutation_p.S566L|MRE11A_ENST00000393241.4_Missense_Mutation_p.S563L|MRE11A_ENST00000323977.3_Missense_Mutation_p.S563L	NM_005591.3	NP_005582.1	P49959	MRE11_HUMAN	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	563					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity	p.S563L(2)		breast(5)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	29		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				GGTTGCTGCTGAGATGCTATC	0.483000								Homologous recombination	Ataxia-Telangiectasia-Like Disorder				73	196					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99827651	99827651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:99827651G>A	ENST00000524871.1	+	8	1077	c.787G>A	c.(787-789)Gat>Aat	p.D263N	CNTN5_ENST00000279463.3_Missense_Mutation_p.D263N|CNTN5_ENST00000528682.1_Missense_Mutation_p.D263N|CNTN5_ENST00000527185.1_Missense_Mutation_p.D263N|CNTN5_ENST00000418526.2_Missense_Mutation_p.D189N	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	263	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCAAACATCAGATGTTGGCAG	0.463000													19	33					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903942	5903942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5903942G>A	ENST00000378961.4	+	4	1356	c.1152G>A	c.(1150-1152)gaG>gaA	p.E384E		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	384						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						GGGATGAGGAGGACAAGAGAA	0.552000													27	125					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325888	31325888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31325888C>T	ENST00000269197.5	+	12	6076	c.6076C>T	c.(6076-6078)Cct>Tct	p.P2026S		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	2026	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						tccccctccccctccaccctt	0.592000													6	11					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73569264	73569264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73569264C>T	ENST00000392550.3	+	20	2747	c.2630C>T	c.(2629-2631)tCg>tTg	p.S877L	LLGL2_ENST00000577200.1_Missense_Mutation_p.S877L|LLGL2_ENST00000167462.5_Missense_Mutation_p.S877L	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	877					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CAGGTGGTCTCGCTGCCCCTG	0.652000													20	54					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038215	75038215	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75038215C>T	ENST00000326665.5	-	14	3397	c.3179G>A	c.(3178-3180)cGa>cAa	p.R1060Q	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1060	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AGCTTTCCTTCGCTCTCTTGC	0.428000													71	191					0	0	1	0	0
CEACAM1	634	broad.mit.edu	37	19	43023124	43023124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43023124C>T	ENST00000161559.6	-	5	1356	c.1222G>A	c.(1222-1224)Gac>Aac	p.D408N	CEACAM1_ENST00000352591.5_Intron|LIPE-AS1_ENST00000457234.2_RNA|CEACAM1_ENST00000599389.1_Intron|LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA|CEACAM1_ENST00000351134.3_Intron|CEACAM1_ENST00000403444.3_Missense_Mutation_p.D408N|CEACAM1_ENST00000403461.1_Intron|CEACAM1_ENST00000358394.3_Intron|CEACAM1_ENST00000308072.4_Intron	NM_001712.4	NP_001703.2	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	408	Ig-like C2-type 3.				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	17		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	ATGATGGGGTCGCTTTGGTTC	0.488000													22	125					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87679359	87679359	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87679359G>A	ENST00000320005.5	-	6	693	c.646C>T	c.(646-648)Cga>Tga	p.R216*		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	216					signal transduction|visual perception	integral to membrane	cGMP binding	p.R216*(1)		NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AGATAGAGTCGATCTGGAAAA	0.453000													8	21					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115341719	115341719	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115341719A>T	ENST00000351270.3	+	9	1019	c.923A>T	c.(922-924)gAg>gTg	p.E308V	HABP2_ENST00000542051.1_Missense_Mutation_p.E282V|HABP2_ENST00000541666.1_Intron	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	308					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		GAGATAGCAGAGAGGAAGATC	0.557000													46	124					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316985	30316985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30316985C>T	ENST00000375377.1	-	3	2193	c.2092G>A	c.(2092-2094)Gag>Aag	p.E698K		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	698										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CTTTGGGGCTCCTCGGAGAAA	0.547000													14	46					0	0	1	0	0
SGK2	10110	broad.mit.edu	37	20	42195138	42195138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42195138G>A	ENST00000341458.4	+	1	402	c.183G>A	c.(181-183)atG>atA	p.M61I	SGK2_ENST00000423407.3_Start_Codon_SNP_p.M1I|SGK2_ENST00000373077.1_Start_Codon_SNP_p.M1I|SGK2_ENST00000426287.1_Missense_Mutation_p.M27I|SGK2_ENST00000373092.3_Start_Codon_SNP_p.M1I|SGK2_ENST00000373100.1_Start_Codon_SNP_p.M1I	NM_016276.3	NP_057360.2	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2	61					intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GCTACAGAATGAACTCTAGCC	0.597000													23	82					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457608	45457608	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45457608C>T	ENST00000548424.1	+	0	448																											GTCACTGGTTCTGGATTGGGC	0.502000													18	59					0	0	1	0	0
PPIA	5478	broad.mit.edu	37	7	44839450	44839450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44839450C>T	ENST00000468812.1	+	4	384	c.339C>T	c.(337-339)ttC>ttT	p.F113F	PPIA_ENST00000451562.1_Silent_p.F113F|PPIA_ENST00000489459.1_Silent_p.F53F|PPIA_ENST00000480603.1_3'UTR|PPIA_ENST00000355968.6_Silent_p.F53F	NM_021130.3	NP_066953.1	P62937	PPIA_HUMAN	peptidylprolyl isomerase A (cyclophilin A)	113	PPIase cyclophilin-type.				entry into host cell|leukocyte migration|platelet activation|platelet degranulation|protein folding|provirus integration|regulation of viral genome replication|RNA-dependent DNA replication|uncoating of virus	cytosol|extracellular region|nucleus	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding|virion binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4					Cyclosporine(DB00091)|L-Proline(DB00172)	CCCAGTTTTTCATCTGCACTG	0.468000													39	83					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28710605	28710605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28710605C>T	ENST00000257198.5	-	16	2818	c.2557G>A	c.(2557-2559)Gaa>Aaa	p.E853K	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257197.3_3'UTR	NM_024421.2	NP_077739.1	Q08554	DSC1_HUMAN	desmocollin 1	853					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CCTTTGCCTTCATAGTTATAC	0.428000													55	133					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33140081	33140081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33140081G>A	ENST00000341947.2	-	40	3200	c.2973C>T	c.(2971-2973)ggC>ggT	p.G991G	COL11A2_ENST00000357486.1_Silent_p.G970G|COL11A2_ENST00000361917.1_Silent_p.G884G|COL11A2_ENST00000374708.4_Silent_p.G905G|COL11A2_ENST00000395197.1_Silent_p.G931G|COL11A2_ENST00000374712.1_Silent_p.G910G|COL11A2_ENST00000374713.1_Silent_p.G944G|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374714.1_Silent_p.G965G	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	991	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TGCCTGGGAGGCCTCTCTCTC	0.632000													3	7					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189912957	189912957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189912957C>T	ENST00000374866.3	-	45	3453	c.3179G>A	c.(3178-3180)cGg>cAg	p.R1060Q		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1060					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AGCACCATCCCGTCCTGGGGT	0.348000													22	55					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	158074137	158074137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:158074137C>T	ENST00000264428.4	+	9	1442	c.1172C>T	c.(1171-1173)aCt>aTt	p.T391I	GLRB_ENST00000541722.1_Intron|GLRB_ENST00000509282.1_Missense_Mutation_p.T391I|GLRB_ENST00000512619.1_Intron	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	391					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GGAACAGGGACTCCTGTTCAT	0.408000													19	39					0	0	1	0	0
EIF4E1B	253314	broad.mit.edu	37	5	176072431	176072431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176072431G>A	ENST00000318682.6	+	8	1112	c.528G>A	c.(526-528)ggG>ggA	p.G176G	EIF4E1B_ENST00000512734.1_3'UTR|EIF4E1B_ENST00000504597.1_Silent_p.G176G	NM_001099408.1	NP_001092878.1	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E family member 1B	176					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			breast(1)|large_intestine(1)|lung(2)|pancreas(1)	5	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGTATGTGGGGCCGTCGTCA	0.617000													14	40					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39432079	39432079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39432079C>T	ENST00000280481.7	+	13	7340	c.7124C>T	c.(7123-7125)cCt>cTt	p.P2375L		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2375					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCTTCTGTCCCTCAAATTGTA	0.428000													30	131					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6832146	6832146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6832146C>T	ENST00000304076.2	+	15	1537	c.1443C>T	c.(1441-1443)ggC>ggT	p.G481G	VAV1_ENST00000539284.1_Silent_p.G384G|VAV1_ENST00000602142.1_Silent_p.G481G|VAV1_ENST00000599806.1_Silent_p.G426G|VAV1_ENST00000596764.1_Silent_p.G449G	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	481	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						GTGCCCAGGGCTATGAGCTGT	0.557000													17	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067464	9067464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9067464C>T	ENST00000397910.4	-	3	20185	c.19982G>A	c.(19981-19983)gGa>gAa	p.G6661E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6663	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGCTGGTTCCCTTCAGCCC	0.512000													27	63					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956040	18956040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18956040G>A	ENST00000302797.3	-	1	516	c.292C>T	c.(292-294)Ctc>Ttc	p.L98F	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	98					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ACAGGATAGAGGATTTTAGAG	0.532000													50	139					0	0	1	0	0
H2BFWT	158983	broad.mit.edu	37	X	103267933	103267933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:103267933C>T	ENST00000217926.5	-	1	326	c.300G>A	c.(298-300)cgG>cgA	p.R100R		NM_001002916.3	NP_001002916.2	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	100					nucleosome assembly	nuclear membrane|nucleosome	DNA binding	p.R100R(1)		breast(2)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	16						TCACGGCCTCCCGGGAAAGGC	0.637000													13	18					0	0	1	0	0
OR51I1	390063	broad.mit.edu	37	11	5462037	5462037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5462037C>T	ENST00000380211.1	-	1	707	c.708G>A	c.(706-708)cgG>cgA	p.R236R	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001005288.2	NP_001005288.1	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I, member 1	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGCCTTGAGCCGCTGTTCCT	0.478000													13	32					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63149732	63149732	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63149732C>T	ENST00000279178.3	+	6	1305	c.1056C>T	c.(1054-1056)tcC>tcT	p.S352S	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	352					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						AAAGGATCTCCCTCCTGTCCT	0.403000													42	108					0	0	1	0	0
GNG7	2788	broad.mit.edu	37	19	2515055	2515055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2515055G>A	ENST00000382159.3	-	5	369	c.172C>T	c.(172-174)Ccc>Tcc	p.P58S		NM_052847.2	NP_443079.1	O60262	GBG7_HUMAN	guanine nucleotide binding protein (G protein), gamma 7	58					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity			central_nervous_system(2)|large_intestine(1)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTTAAAGGGGTTCTCCGAG	0.493000													34	96					0	0	1	0	0
SPATA31D3	389762	broad.mit.edu	37	9	84564044	84564044	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84564044C>T	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							GCCCAGGGTCCCTACGCATGT	0.532000													14	32					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100192536	100192536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100192536C>T	ENST00000554176.1	+	9	1452	c.786C>T	c.(784-786)ttC>ttT	p.F262F	CYP46A1_ENST00000261835.3_Silent_p.F425F|CYP46A1_ENST00000423126.2_Silent_p.F328F			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	425					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GGCCACGGTTCACCTACTTCC	0.607000													15	47					0	0	1	0	0
CRY1	1407	broad.mit.edu	37	12	107393622	107393622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107393622G>A	ENST00000008527.5	-	7	1711	c.844C>T	c.(844-846)Cct>Tct	p.P282S		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	282	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						GAAAGGGGAGGGGAACTGTTC	0.333000													25	49					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11302087	11302087	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11302087G>A	ENST00000397056.1	+	3	1555	c.1364G>A	c.(1363-1365)tGg>tAg	p.W455*	HRH1_ENST00000431010.2_Nonsense_Mutation_p.W455*|HRH1_ENST00000438284.2_Nonsense_Mutation_p.W455*	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	455					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	TTCACCATCTGGCTGGGCTAC	0.453000													41	208					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94044314	94044314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94044314G>A	ENST00000553484.1	+	18	2492	c.2338G>A	c.(2338-2340)Gga>Aga	p.G780R	UNC79_ENST00000555664.1_Missense_Mutation_p.G780R|UNC79_ENST00000393151.2_Missense_Mutation_p.G780R|UNC79_ENST00000256339.4_Missense_Mutation_p.G603R			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	780						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CAAGAATTTTGGACACCCAGG	0.423000													57	122					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060233	54060233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54060233C>T	ENST00000312233.2	-	3	909	c.343G>A	c.(343-345)Ggc>Agc	p.G115S		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	115					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						TTGGAAGGGCCCCCCAGATCT	0.647000													10	51					0	0	1	0	0
TWF1	5756	broad.mit.edu	37	12	44191132	44191132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:44191132G>A	ENST00000395510.2	-	7	862	c.733C>T	c.(733-735)Cat>Tat	p.H245Y	TWF1_ENST00000552521.1_Missense_Mutation_p.H147Y|TWF1_ENST00000325127.4_Missense_Mutation_p.H279Y|TWF1_ENST00000548315.1_Missense_Mutation_p.H252Y	NM_001242397.1|NM_002822.4	NP_001229326.1|NP_002813.3	Q12792	TWF1_HUMAN	twinfilin actin-binding protein 1	245	ADF-H 2.					actin cytoskeleton|cytoplasm	actin binding|protein tyrosine kinase activity			endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|stomach(1)	14	all_cancers(12;0.00125)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.0474)		TCTCCTTCATGGGAATGTTTA	0.333000													13	133					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100549576	100549576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100549576C>T	ENST00000379458.4	+	2	157	c.157C>T	c.(157-159)Ctg>Ttg	p.53_53insL	MUC3A_ENST00000483366.1_3'UTR					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						CTCCAGAGACCTGGCTGGGTG	0.582000													28	131					0	0	1	0	0
CHMP2B	25978	broad.mit.edu	37	3	87302653	87302653	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:87302653C>T	ENST00000263780.4	+	5	762	c.524C>T	c.(523-525)tCt>tTt	p.S175F	CHMP2B_ENST00000494980.1_Missense_Mutation_p.S145F|CHMP2B_ENST00000471660.1_Missense_Mutation_p.S134F	NM_014043.3	NP_054762.2	Q9UQN3	CHM2B_HUMAN	charged multivesicular body protein 2B	175					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane|mitochondrion|nucleus	protein domain specific binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	12	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		ATTGAAATTTCTGGAAAGGTA	0.353000													6	53					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78922032	78922032	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78922032G>A	ENST00000261751.3	-	5	726	c.615C>T	c.(613-615)gcC>gcT	p.A205A	CHRNB4_ENST00000412074.2_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	205					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						TCCCTGGGAGGGCCACTATGT	0.552000													80	97					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104638985	104638985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104638985C>T	ENST00000315264.7	+	6	1361	c.983C>T	c.(982-984)tCc>tTc	p.S328F	KIF26A_ENST00000423312.2_Missense_Mutation_p.S467F			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	467					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		TGCATTTTTTCCTTTGGCCAC	0.632000													19	29					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207135558	207135558	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207135558C>T	ENST00000324852.4	-	5	1126	c.652_splice	c.e5+1	p.G218_splice	FCAMR_ENST00000450945.2_Splice_Site_p.V218_splice|FCAMR_ENST00000400962.3_Splice_Site_p.V218_splice	NM_001170631.1	NP_001164102.1	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity	173						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(1)	11						CAGCTCATACCTGCAGAGATG	0.512000													17	50					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935684	30935684	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30935684C>T	ENST00000355537.3	+	2	1362	c.1215C>T	c.(1213-1215)tcC>tcT	p.S405S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGAACAAGTCCCCCAGCGACC	0.622000													6	57					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3334456	3334456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3334456G>A	ENST00000378398.3	+	12	2838	c.2756G>A	c.(2755-2757)gGc>gAc	p.G919D	PRDM16_ENST00000378391.2_Missense_Mutation_p.G919D|PRDM16_ENST00000270722.5_Missense_Mutation_p.G919D|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Missense_Mutation_p.G918D|PRDM16_ENST00000441472.2_Missense_Mutation_p.G918D|PRDM16_ENST00000514189.1_Missense_Mutation_p.G919D|PRDM16_ENST00000511072.1_Missense_Mutation_p.G920D			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	919	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCGGACTCGGGCAGCTCCCTG	0.602000			T	EVI1	"""MDS, AML"""								38	109					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49167284	49167284	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49167284G>A	ENST00000418109.1	-	11	1557	c.1393C>T	c.(1393-1395)Ctg>Ttg	p.L465L	LAMB2_ENST00000305544.4_Silent_p.L465L	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	465	Laminin EGF-like 3.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGGCAGCCCAGACGGTCACTG	0.572000													30	119					0	0	1	0	0
EXOC6	54536	broad.mit.edu	37	10	94708030	94708030	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:94708030G>A	ENST00000371552.4	+	14	1324		c.e14-1		EXOC6_ENST00000443748.2_Splice_Site|EXOC6_ENST00000260762.6_Splice_Site|EXOC6_ENST00000371547.4_Splice_Site	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6						protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				TTTCCTAACAGGGACATTTTT	0.318000													30	45					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170573	90170573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:90170573G>A	ENST00000333209.3	-	2	1207	c.689C>T	c.(688-690)tCt>tTt	p.S230F		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	230										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		CCTCATTTCAGAGTCACAGAT	0.547000													22	52					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40412180	40412180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40412180G>A	ENST00000221347.6	-	7	3455	c.3448C>T	c.(3448-3450)Ccg>Tcg	p.P1150S		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1150	Cys-rich.|TIL 2.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CAGGACAGCGGGCAGCCGTAG	0.622000													15	56					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16859997	16859997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16859997G>A	ENST00000524140.2	+	6	962	c.544G>A	c.(544-546)Gaa>Aaa	p.E182K	NWD1_ENST00000523826.1_5'UTR|NWD1_ENST00000379808.3_Missense_Mutation_p.E182K|NWD1_ENST00000339803.6_Missense_Mutation_p.E47K|NWD1_ENST00000552788.1_Missense_Mutation_p.E182K|NWD1_ENST00000549814.1_Missense_Mutation_p.E182K	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	182							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AGAGGACCGGGAACAGGGAGC	0.572000													19	48					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25365205	25365205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:25365205C>T	ENST00000330560.3	+	15	3500	c.3023C>T	c.(3022-3024)tCt>tTt	p.S1008F	CDCA2_ENST00000380665.3_Missense_Mutation_p.S993F|CDCA2_ENST00000521098.2_3'UTR	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	1008					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		GGAGAGAGCTCTCTGACTGCC	0.433000													33	90					0	0	1	0	0
FBXO4	26272	broad.mit.edu	37	5	41929924	41929924	+	Missense_Mutation	SNP	C	C	T	rs139473757		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41929924C>T	ENST00000296812.2	+	3	607	c.551C>T	c.(550-552)cCa>cTa	p.P184L	FBXO4_ENST00000281623.3_Missense_Mutation_p.P184L|FBXO4_ENST00000509134.1_Missense_Mutation_p.P184L	NM_033484.2	NP_277019.1	Q9UKT5	FBX4_HUMAN	F-box protein 4	184					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(11)|prostate(1)|stomach(1)|urinary_tract(2)	27		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				ATGTTTGGACCAGGTTTGGAA	0.433000													65	175					0	0	1	0	0
PGD	5226	broad.mit.edu	37	1	10479767	10479767	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10479767C>T	ENST00000538557.1	+	13	1618	c.1374C>T	c.(1372-1374)ggC>ggT	p.G458G	PGD_ENST00000270776.8_Silent_p.G471G|PGD_ENST00000541529.1_Silent_p.G449G|PGD_ENST00000498356.1_3'UTR			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	471					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		ACTGGACAGGCCATGGTGGCA	0.547000													16	117					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184298401	184298401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184298401C>T	ENST00000330394.2	+	12	2836	c.2384C>T	c.(2383-2385)tCc>tTc	p.S795F	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	795	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TACACCAGTTCCCTGGTACAG	0.642000													30	66					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10353916	10353916	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10353916G>A	ENST00000255381.2	-	30	4145	c.4035C>T	c.(4033-4035)gaC>gaT	p.D1345D	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1345					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CCCGCAGCAGGTCACAGTCAT	0.532000													39	45					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47423267	47423267	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47423267C>T	ENST00000404338.3	+	1	1335	c.1335C>T	c.(1333-1335)ttC>ttT	p.F445F		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	445	FF 3.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CTTCTCCTTTCATAACTCCCG	0.453000													7	74					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48547612	48547612	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48547612G>A	ENST00000435803.1	+	50	13515	c.13491G>A	c.(13489-13491)agG>agA	p.R4497R	ABCA13_ENST00000544596.1_Silent_p.R227R	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4497					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTGGCTACAGGATGTACTGGT	0.488000													8	34					0	0	1	0	0
TRBV30	28557	broad.mit.edu	37	7	142511029	142511029	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142511029G>A	ENST00000417977.2	-	0	55																											CCTCTTCTGGGCCAGTGATGT	0.562000													3	2					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995641	140995641	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140995641C>T	ENST00000285879.4	+	4	2737	c.2451C>T	c.(2449-2451)ttC>ttT	p.F817F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	817							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGCTCCTTCCCCTCCTCCA	0.557000										HNSCC(15;0.026)			85	125					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127776	152127776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152127776C>T	ENST00000316073.3	-	3	1863	c.1799G>A	c.(1798-1800)gGg>gAg	p.G600E		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	600	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TCCTTCAGTCCCTTGGAAGTA	0.453000													100	260					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142625187	142625187	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142625187C>T	ENST00000265310.1	-	7	1253	c.905G>A	c.(904-906)cGa>cAa	p.R302Q	TRPV5_ENST00000442623.1_Missense_Mutation_p.R302Q	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	302					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CCATACCTCTCGTTTATCAGA	0.522000													13	66					0	0	1	0	0
INTS9	55756	broad.mit.edu	37	8	28695168	28695168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:28695168G>A	ENST00000416984.2	-	4	683	c.324C>T	c.(322-324)acC>acT	p.T108T	INTS9_ENST00000521022.1_Silent_p.T129T|INTS9_ENST00000521777.1_Silent_p.T105T|INTS9_ENST00000397363.4_Silent_p.T23T	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	129					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		CGATCTGGACGGTGGGTTCCG	0.532000													5	30					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218616	130218616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130218616G>A	ENST00000276211.5	+	6	1110	c.765G>A	c.(763-765)ggG>ggA	p.G255G	ARHGAP36_ENST00000370921.1_Silent_p.G119G|ARHGAP36_ENST00000370922.1_Silent_p.G243G	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	255	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GCGCAGTGGGGATTTTTACCC	0.488000													47	43					0	0	1	0	0
FOXR2	139628	broad.mit.edu	37	X	55650496	55650496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:55650496G>A	ENST00000339140.3	+	1	664	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	118					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						ACAAAAAGACGAAGGGTCTAA	0.527000													3	26					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83634662	83634662	+	Silent	SNP	G	G	A	rs138570323	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83634662G>A	ENST00000265362.3	-	11	1667	c.1353C>T	c.(1351-1353)atC>atT	p.I451I	SEMA3A_ENST00000436949.1_Silent_p.I451I	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	451	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						TACCTGTTCCGATAAACATAA	0.358000													20	96					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15452403	15452403	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:15452403C>T	ENST00000341776.2	+	4	734	c.490C>T	c.(490-492)Cga>Tga	p.R164*	JARID2_ENST00000397311.3_5'UTR|JARID2_ENST00000541660.1_Nonsense_Mutation_p.R126*	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	164					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding	p.R164*(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				TCTCTGCCTTCGAGGTAAGAC	0.468000													11	89					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36381037	36381037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36381037C>T	ENST00000373204.4	+	15	2135	c.1922C>T	c.(1921-1923)tCc>tTc	p.S641F	AGO1_ENST00000373206.1_Missense_Mutation_p.S566F	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GAAGACTTGTCCTACATGGTG	0.547000													31	97					0	0	1	0	0
ECT2L	345930	broad.mit.edu	37	6	139175174	139175174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:139175174G>A	ENST00000423192.1	+	9	1242	c.1081G>A	c.(1081-1083)Ggt>Agt	p.G361S	ECT2L_ENST00000495970.1_3'UTR|ECT2L_ENST00000541398.1_Missense_Mutation_p.G292S|ECT2L_ENST00000367682.2_Missense_Mutation_p.G361S			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	361					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.G361C(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						CTATAAAATTGGTGTTAAAAA	0.363000			"""N, Splice, Mis"""		ETP ALL								50	82					0	0	1	0	0
HLA-B	3106	broad.mit.edu	37	6	31322989	31322989	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31322989G>A	ENST00000412585.2	-	5	935	c.907C>T	c.(907-909)Cag>Tag	p.Q303*		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						ACGGTGGACTGGGAAGACGGC	0.602000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				24	55					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885620	180885620	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:180885620G>A	ENST00000367588.4	+	2	436	c.381G>A	c.(379-381)ggG>ggA	p.G127G		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	127										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GGAGAGCCGGGACTCCATCAG	0.597000													10	143					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61945235	61945235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61945235G>A	ENST00000422202.1	+	17	2439	c.2371G>A	c.(2371-2373)Gag>Aag	p.E791K	COL20A1_ENST00000326996.6_Missense_Mutation_p.E784K|COL20A1_ENST00000435874.1_Missense_Mutation_p.E791K|COL20A1_ENST00000358894.6_Missense_Mutation_p.E784K			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	784	Fibronectin type-III 6.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CTTGGGACCCGAGAAATCCGT	0.672000													4	32					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79351478	79351478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79351478G>A	ENST00000264895.6	+	37	5316	c.4876G>A	c.(4876-4878)Gcg>Acg	p.A1626T	FRAS1_ENST00000325942.6_Missense_Mutation_p.A1626T	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1625					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGCTGAGACAGCGCCCAAAGA	0.483000													18	46					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19766365	19766365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19766365G>A	ENST00000357324.6	-	10	1394	c.1368C>T	c.(1366-1368)atC>atT	p.I456I	ATP13A1_ENST00000291503.5_Silent_p.I338I|ATP13A1_ENST00000496082.1_5'UTR	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	456	Poly-Ala.				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CAGCTGCAGCGATGGCAAACA	0.607000													18	31					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23522873	23522873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:23522873C>T	ENST00000296682.3	+	8	943	c.761C>T	c.(760-762)cCt>cTt	p.P254L		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	254	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TCAGGCATCCCTCAGGCTGGG	0.582000										HNSCC(3;0.000094)			5	57					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92470193	92470193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92470193G>A	ENST00000267622.4	-	11	4500	c.4127C>T	c.(4126-4128)tCg>tTg	p.S1376L		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1376					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		GGCAGCAATCGAATCAGACAA	0.378000			T	PDGFRB	AML								49	105					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17539531	17539531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17539531C>T	ENST00000229922.2	+	8	1200	c.668C>T	c.(667-669)tCt>tTt	p.S223F	CAP2_ENST00000489374.1_Missense_Mutation_p.S111F|CAP2_ENST00000493172.1_Intron|CAP2_ENST00000465994.1_Missense_Mutation_p.S159F|CAP2_ENST00000378990.2_Missense_Mutation_p.S197F	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	223					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			TCAGCGTTTTCTGTCCTCTCC	0.552000													77	145					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42778721	42778721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42778721G>A	ENST00000330714.3	+	13	1885	c.1701G>A	c.(1699-1701)atG>atA	p.M567I		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	567					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CAGAAAACATGATCCAACTTC	0.368000													26	74					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2272573	2272573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:2272573G>A	ENST00000290974.2	-	13	2882	c.2543C>T	c.(2542-2544)tCg>tTg	p.S848L	ZFYVE28_ENST00000508471.1_Missense_Mutation_p.S153L|ZFYVE28_ENST00000515312.1_Missense_Mutation_p.S778L|ZFYVE28_ENST00000511071.1_Missense_Mutation_p.S818L	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	848					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GGAGCAGCGCGAGCAGAAGAT	0.657000													4	30					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9434089	9434089	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9434089G>A	ENST00000378501.2	+	29	2955	c.2940G>A	c.(2938-2940)gaG>gaA	p.E980E	PLCB4_ENST00000414679.2_Silent_p.E992E|PLCB4_ENST00000378493.1_Silent_p.E980E|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Silent_p.E980E|PLCB4_ENST00000378473.3_Silent_p.E992E|PLCB4_ENST00000334005.3_Silent_p.E980E	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	980					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AAATCCTAGAGAAGGCAATGA	0.388000													8	76					0	0	1	0	0
LGI3	203190	broad.mit.edu	37	8	22006318	22006318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22006318G>A	ENST00000306317.2	-	8	1291	c.1002C>T	c.(1000-1002)gcC>gcT	p.A334A	LGI3_ENST00000424267.2_Silent_p.A310A	NM_139278.2	NP_644807.1	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	334					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	17				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CGATGCGGAAGGCTTCTAGGT	0.607000													13	32					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73280619	73280619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73280619C>T	ENST00000286657.4	-	4	610	c.574G>A	c.(574-576)Gaa>Aaa	p.E192K		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	192					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCTTTTTCTTCCTCCATCTGT	0.388000													36	85					0	0	1	0	0
RAB4B-EGLN2	100529264	broad.mit.edu	37	19	41292841	41292841	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41292841C>T	ENST00000594136.1	+	7	720	c.615C>T	c.(613-615)gcC>gcT	p.A205A	RAB4B_ENST00000594800.1_Silent_p.A205A|RAB4B_ENST00000357052.2_Silent_p.A205A|RAB4B-EGLN2_ENST00000601949.1_3'UTR														p.A240A(1)									GTGCCCAGGCCGTGGCCCCTC	0.682000													5	52					0	0	1	0	0
ZNF678	339500	broad.mit.edu	37	1	227843293	227843293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:227843293C>T	ENST00000343776.4	+	4	1687	c.1342C>T	c.(1342-1344)Ctt>Ttt	p.L448F	ZNF678_ENST00000397097.3_Missense_Mutation_p.L503F|ZNF678_ENST00000498759.1_Intron			F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	503					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				ATCCTCAATCCTTAGTAAGCA	0.378000													26	78					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55179383	55179383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55179383C>T	ENST00000391736.1	+	14	1575	c.1260C>T	c.(1258-1260)ctC>ctT	p.L420L	LILRB4_ENST00000270452.2_Silent_p.L420L|LILRB4_ENST00000430952.2_Silent_p.L419L|LILRB4_ENST00000391733.3_Silent_p.L421L|LILRB4_ENST00000391734.3_Silent_p.L367L	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	420						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GCTTTACCCTCAGACAGAAGG	0.627000													28	120					0	0	1	0	0
CAMKK2	10645	broad.mit.edu	37	12	121683011	121683011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121683011G>A	ENST00000324774.5	-	15	2313	c.1485C>T	c.(1483-1485)tcC>tcT	p.S495S	CAMKK2_ENST00000545538.1_Silent_p.S282S|CAMKK2_ENST00000412367.2_Silent_p.S495S|CAMKK2_ENST00000392473.2_Silent_p.S495S|CAMKK2_ENST00000404169.3_Silent_p.S495S|CAMKK2_ENST00000402834.4_Silent_p.S495S|CAMKK2_ENST00000538733.1_Silent_p.S452S|CAMKK2_ENST00000392474.2_Silent_p.S495S|CAMKK2_ENST00000347034.2_Silent_p.S452S|CAMKK2_ENST00000446440.2_Silent_p.S452S|CAMKK2_ENST00000337174.3_Silent_p.S495S	NM_006549.3	NP_006540.3	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase kinase 2, beta	495	Calmodulin-binding (By similarity).				calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GGTTCCCAAAGGAGCGTTTAC	0.592000													4	5					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143586489	143586489	+	Missense_Mutation	SNP	G	G	A	rs146836865		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:143586489G>A	ENST00000507359.2	+	2	1303	c.212G>A	c.(211-213)gGa>gAa	p.G71E	KCTD16_ENST00000512467.1_Missense_Mutation_p.G71E	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16	71	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			GACTCCAAGGGAAGGTTTTTC	0.463000													12	28					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108872050	108872050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108872050C>T	ENST00000329106.2	+	4	422	c.422C>T	c.(421-423)cCc>cTc	p.P141L	SULT1C3_ENST00000376700.1_Missense_Mutation_p.P141L	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	141						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						GCCAGAAATCCCAAGGATTGC	0.423000													50	114					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180280	124180280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124180280C>T	ENST00000357821.2	-	1	453	c.383G>A	c.(382-384)aGc>aAc	p.S128N		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AAGCAGTGGGCTACAGATGGC	0.498000													6	26					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697719	6697719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6697719C>T	ENST00000245907.6	-	20	2619	c.2527G>A	c.(2527-2529)Gag>Aag	p.E843K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	843					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TCCACCTGCTCGTTTCGAACA	0.587000													41	30					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42285037	42285037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42285037G>A	ENST00000399518.3	-	13	1854	c.1368C>T	c.(1366-1368)ctC>ctT	p.L456L	CTD-2382E5.1_ENST00000499478.2_RNA|PLA2G4E_ENST00000413860.2_Silent_p.L427L	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	444	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GGAATTTGCGGAGCTGGTCTG	0.582000													28	45					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155959	151155959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151155959C>T	ENST00000282466.3	-	6	6389	c.6390G>A	c.(6388-6390)atG>atA	p.M2130I	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2130	Ig-like C2-type 7.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGTGGACCTTCATTTCATCTT	0.443000													14	49					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125083792	125083792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125083792G>A	ENST00000522917.1	+	31	4218	c.4012G>A	c.(4012-4014)Gac>Aac	p.D1338N	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.D1338N	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1338						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TAGCTCTGAGGACAGCGGGCA	0.507000													16	39					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440711	124440711	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124440711G>A	ENST00000284287.3	+	1	819	c.747G>A	c.(745-747)ggG>ggA	p.G249G		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		CCACAGAGGGGAGATCCAAAG	0.478000													28	89					0	0	1	0	0
DDO	8528	broad.mit.edu	37	6	110714266	110714266	+	Silent	SNP	C	C	T	rs148812598	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110714266C>T	ENST00000368924.3	-	5	837	c.822G>A	c.(820-822)ccG>ccA	p.P274P	DDO_ENST00000368923.3_Silent_p.P215P|DDO_ENST00000368925.1_Silent_p.P246P	NM_003649.2	NP_003640.2	Q99489	OXDD_HUMAN	D-aspartate oxidase	246					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|pancreas(1)|skin(3)	24		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		TTTCTGCATCCGGGGACAGAT	0.522000													52	90					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80714267	80714267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80714267G>A	ENST00000458043.2	+	33	3847	c.3841G>A	c.(3841-3843)Gat>Aat	p.D1281N	OTOGL_ENST00000547103.1_Missense_Mutation_p.D1281N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CCATGACAATGATACTCTTAG	0.448000													9	38					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277759	114277759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114277759C>T	ENST00000357077.4	+	38	8038	c.7985C>T	c.(7984-7986)tCc>tTc	p.S2662F	ANK2_ENST00000264366.6_Missense_Mutation_p.S2629F|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2629					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGGTGTCTTCCTCCTCAGAA	0.478000													22	68					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857825	9857825	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9857825G>A	ENST00000396573.2	-	14	3885	c.3576C>T	c.(3574-3576)acC>acT	p.T1192T	GRIN2A_ENST00000404927.2_Silent_p.T1192T|GRIN2A_ENST00000562109.1_Silent_p.T1192T|GRIN2A_ENST00000330684.3_Silent_p.T1192T|GRIN2A_ENST00000396575.2_Silent_p.T1192T|GRIN2A_ENST00000535259.1_Silent_p.T1035T	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1192					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTCTTTCAAGGTGAAGTGCT	0.542000													127	248					0	0	1	0	0
UGT1A8	54576	broad.mit.edu	37	2	234526842	234526842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234526842C>T	ENST00000373450.4	+	1	552	c.489C>T	c.(487-489)ctC>ctT	p.L163L		NM_019076.4	NP_061949.3														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		ATTTCTCCCTCCCCTCTGTGG	0.453000													63	270					0	0	1	0	0
ATP13A2	23400	broad.mit.edu	37	1	17318748	17318748	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17318748G>A	ENST00000452699.1	-	18	2169	c.1980C>T	c.(1978-1980)aaC>aaT	p.N660N	RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000341676.5_Silent_p.N660N|ATP13A2_ENST00000326735.8_Silent_p.N665N	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	665					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CTGTCTCGGGGTTGCAGAGCC	0.677000													16	25					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27087520	27087520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27087520C>T	ENST00000324856.7	+	5	2465	c.2094C>T	c.(2092-2094)tcC>tcT	p.S698S	ARID1A_ENST00000457599.2_Silent_p.S698S|ARID1A_ENST00000374152.2_Silent_p.S315S	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	698					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTTCCCCGTCCCCTGTTGGCT	0.607000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								29	68					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70079869	70079869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70079869G>A	ENST00000446444.1	-	1	580	c.572C>T	c.(571-573)cCt>cTt	p.P191L	RP11-704M14.1_ENST00000505646.1_RNA|RP11-704M14.1_ENST00000504301.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	191					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						TATGTAGGAAGGAGGGAAAAT	0.403000													14	114					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	166958637	166958637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:166958637C>T	ENST00000392766.2	-	21	2687	c.2347G>A	c.(2347-2349)Gaa>Aaa	p.E783K	ZBBX_ENST00000307529.5_Missense_Mutation_p.E822K|ZBBX_ENST00000392764.1_Missense_Mutation_p.E754K|ZBBX_ENST00000392767.2_Missense_Mutation_p.E783K|ZBBX_ENST00000455345.2_Missense_Mutation_p.E822K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	783	Poly-Glu.					intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AGAAAATCTTCCTCCTCCTCA	0.368000													38	81					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86790910	86790910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86790910G>A	ENST00000441037.2	+	6	492	c.397G>A	c.(397-399)Ggc>Agc	p.G133S	AGBL1_ENST00000421325.2_Missense_Mutation_p.G133S	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	133					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						AGAGTCGAACGGCCGCAGAGC	0.562000													3	16					0	0	1	0	0
MIPEP	4285	broad.mit.edu	37	13	24455909	24455909	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:24455909G>A	ENST00000382172.3	-	3	479	c.381C>T	c.(379-381)atC>atT	p.I127I	MIPEP_ENST00000469167.1_5'UTR	NM_005932.3	NP_005923.2	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase	127					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(12)|prostate(2)|skin(1)	27		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CAGGGTGAGCGATTTTCACAA	0.458000													13	34					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110441668	110441668	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110441668C>T	ENST00000378402.5	+	26	3204	c.3100C>T	c.(3100-3102)Cgt>Tgt	p.R1034C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1034					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGACCTACTTCGTACACCCAG	0.343000										HNSCC(38;0.096)			5	15					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17373487	17373487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17373487C>T	ENST00000252597.3	-	4	689	c.516G>A	c.(514-516)gaG>gaA	p.E172E	USHBP1_ENST00000431146.2_Silent_p.E108E|USHBP1_ENST00000598570.1_5'UTR	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	172							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						GGCGAGCTGCCTCTCGCTGGC	0.677000													11	114					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	130984581	130984581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130984581C>T	ENST00000341179.7	+	7	1047	c.955C>T	c.(955-957)Cct>Tct	p.P319S	DNM1_ENST00000475805.1_Missense_Mutation_p.P319S|DNM1_ENST00000486160.1_Missense_Mutation_p.P319S|DNM1_ENST00000372923.3_Missense_Mutation_p.P319S|DNM1_ENST00000393594.3_Missense_Mutation_p.P319S	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	319					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						GAACTTCCGCCCTGATGACCC	0.622000													21	31					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111693359	111693359	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111693359G>A	ENST00000431670.2	+	18	4122	c.3711G>A	c.(3709-3711)tgG>tgA	p.W1237*	PHLDB2_ENST00000412622.1_Nonsense_Mutation_p.W1194*|PHLDB2_ENST00000495180.1_Nonsense_Mutation_p.W728*|PHLDB2_ENST00000481953.1_Nonsense_Mutation_p.W1194*|PHLDB2_ENST00000393923.3_Nonsense_Mutation_p.W1221*|PHLDB2_ENST00000393925.3_Nonsense_Mutation_p.W1237*	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	1237	PH.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TGCGGATCTGGATGGATGTTA	0.453000													14	151					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127615	152127615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152127615C>T	ENST00000316073.3	-	3	2024	c.1960G>A	c.(1960-1962)Gat>Aat	p.D654N		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	654	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TGTTGGCTATCCTCTTCAGGC	0.507000													26	89					0	0	1	0	0
ZC4H2	55906	broad.mit.edu	37	X	64139971	64139971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:64139971G>A	ENST00000545618.1	-	4	936	c.373C>T	c.(373-375)Ctt>Ttt	p.L125F	ZC4H2_ENST00000374839.3_Missense_Mutation_p.L130F|ZC4H2_ENST00000447788.2_Missense_Mutation_p.L130F|ZC4H2_ENST00000337990.2_Missense_Mutation_p.L107F|ZC4H2_ENST00000488608.1_5'UTR			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	130							metal ion binding|protein binding			endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TCCAAGGAAAGCTTCTCCTCT	0.522000													6	25					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32158230	32158230	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32158230G>A	ENST00000373672.3	-	15	1643	c.1127C>T	c.(1126-1128)cCg>cTg	p.P376L	COL16A1_ENST00000373668.3_Missense_Mutation_p.P376L|COL16A1_ENST00000271069.6_Missense_Mutation_p.P376L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	376	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTCTCCCTTCGGGCCTTCTGC	0.647000													15	55					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33399952	33399952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33399952C>T	ENST00000418600.2	+	4	411	c.310C>T	c.(310-312)Cgc>Tgc	p.R104C	SYNGAP1_ENST00000428982.2_Missense_Mutation_p.R45C|SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000293748.5_Missense_Mutation_p.R104C	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	104					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						CCACTTGGGTCGCTCGAGGAG	0.632000													16	35					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64643370	64643370	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:64643370C>T	ENST00000587624.1	+	0	777																											CAGAGATATTCGAGAGGCTCT	0.398000													10	45					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46299162	46299162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46299162C>T	ENST00000221538.3	-	6	2261	c.2119G>A	c.(2119-2121)Gag>Aag	p.E707K	RSPH6A_ENST00000597055.1_3'UTR|RSPH6A_ENST00000600188.1_Missense_Mutation_p.E443K	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	707	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						tcctcctcctcgccctcctcc	0.577000													55	86					0	0	1	0	0
DVL3	1857	broad.mit.edu	37	3	183888410	183888410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183888410C>T	ENST00000313143.3	+	15	2266	c.2018C>T	c.(2017-2019)cCc>cTc	p.P673L	EIF2B5_ENST00000444495.1_Intron|DVL3_ENST00000431765.1_Missense_Mutation_p.P656L	NM_004423.3	NP_004414.3	Q92997	DVL3_HUMAN	dishevelled segment polarity protein 3	673					canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(6)|liver(1)|lung(13)|ovary(1)|prostate(1)	35	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CCCCCGCCGCCCGCGGCCATG	0.726000													15	20					0	0	1	0	0
F2R	2149	broad.mit.edu	37	5	76029030	76029030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76029030G>A	ENST00000319211.4	+	2	1245	c.980G>A	c.(979-981)gGa>gAa	p.G327E		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	327					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	ATTTGCTTCGGACCCACAAAC	0.512000													34	101					0	0	1	0	0
PDP1	54704	broad.mit.edu	37	8	94935499	94935499	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:94935499C>T	ENST00000396200.3	+	3	1563	c.1287C>T	c.(1285-1287)caC>caT	p.H429H	PDP1_ENST00000520728.1_Silent_p.H404H|PDP1_ENST00000297598.4_Silent_p.H404H|PDP1_ENST00000517764.1_Silent_p.H404H	NM_001161779.1	NP_001155251.1	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 1	404					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18						TAACTTACCACCGATTAAGGC	0.458000													35	107					0	0	1	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	74005167	74005167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:74005167C>T	ENST00000476977.1	+	24	4103	c.2412C>T	c.(2410-2412)ggC>ggT	p.G804G	GTF2IRD1_ENST00000265755.3_Silent_p.G819G|GTF2IRD1_ENST00000424337.2_Silent_p.G804G|GTF2IRD1_ENST00000455841.2_Silent_p.G836G			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	819						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGGCCCTGGGCCTGAACCGGC	0.607000													16	29					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52945952	52945952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52945952C>T	ENST00000295213.4	+	9	1596	c.1222C>T	c.(1222-1224)Cct>Tct	p.P408S	SPATA18_ENST00000419395.2_Missense_Mutation_p.P376S	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	408					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GATTTCATTCCCTCCTGTCGT	0.438000													75	226					0	0	1	0	0
PAEP	5047	broad.mit.edu	37	9	138454150	138454150	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138454150C>T	ENST00000479141.1	+	2	151	c.107C>T	c.(106-108)aCc>aTc	p.T36I	PAEP_ENST00000371766.2_Missense_Mutation_p.T36I|PAEP_ENST00000277508.5_Missense_Mutation_p.T36I	NM_002571.2	NP_002562.2	P09466	PAEP_HUMAN	progestagen-associated endometrial protein	36				GTW -> VTA (in Ref. 9; AA sequence).|T -> K (in Ref. 7; AA sequence).	multicellular organismal development	extracellular region	binding|transporter activity			cervix(1)|endometrium(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	6				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		TTGGCAGGGACCTGGCACTCC	0.652000													5	39					0	0	1	0	0
SLC36A3	285641	broad.mit.edu	37	5	150666980	150666980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150666980C>T	ENST00000335230.3	-	6	946	c.535G>A	c.(535-537)Gag>Aag	p.E179K	SLC36A3_ENST00000377713.3_Missense_Mutation_p.E220K	NM_181774.3	NP_861439.3	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3	179						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	21		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTCAGAATCTCCCTGGGCTGG	0.507000													7	67					0	0	1	0	0
CCDC138	165055	broad.mit.edu	37	2	109411018	109411018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:109411018C>T	ENST00000295124.4	+	5	477	c.417C>T	c.(415-417)acC>acT	p.T139T	CCDC138_ENST00000412964.2_Silent_p.T139T|CCDC138_ENST00000470608.1_3'UTR	NM_144978.1	NP_659415.1	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	139										endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	14						CTAATACGACCTCATCGAGAC	0.388000													29	75					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24811299	24811299	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24811299C>T	ENST00000221169.5	-	0	1774							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TCCTCGCCTTCCAAGAGTTTC	0.532000													7	17					0	0	1	0	0
TMEM190	147744	broad.mit.edu	37	19	55889179	55889179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55889179G>A	ENST00000291934.3	+	4	248	c.230G>A	c.(229-231)cGg>cAg	p.R77Q	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	77						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GAAAACGTGCGGAGGAAGCAC	0.677000													6	47					0	0	1	0	0
MIR522	574495	broad.mit.edu	37	19	54254478	54254478	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54254478C>T	ENST00000385071.1	+	0	14					NR_030217.1																						CAGGCTGTGTCCCTCTAGAGG	0.413000													51	119					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497178	1497178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1497178C>T	ENST00000421627.2	+	2	453	c.319C>T	c.(319-321)Cgc>Tgc	p.R107C		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	186					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CAAGATCAACCGCATCCCGGC	0.682000													11	13					0	0	1	0	0
TRBC2	28638	broad.mit.edu	37	7	142498732	142498732	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142498732G>A	ENST00000466254.1	+	0	8																											CAGAGGACCTGAAAAACGTGT	0.562000													18	57					0	0	1	0	0
GALNT7	51809	broad.mit.edu	37	4	174169386	174169386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:174169386C>T	ENST00000265000.4	+	2	465	c.382C>T	c.(382-384)Cgc>Tgc	p.R128C	GALNT7_ENST00000512285.1_Missense_Mutation_p.R128C	NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	128					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		TCCTGTGCTTCGCCCAGGGAT	0.512000													32	61					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44797655	44797655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44797655C>T	ENST00000309315.4	+	6	884	c.761C>T	c.(760-762)cCt>cTt	p.P254L	ZMIZ2_ENST00000441627.1_Missense_Mutation_p.P254L|ZMIZ2_ENST00000433667.1_Missense_Mutation_p.P222L|ZMIZ2_ENST00000413916.1_Missense_Mutation_p.P222L|ZMIZ2_ENST00000265346.7_Missense_Mutation_p.P254L	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	254	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TATCCTGGGCCTCCCCAGGCC	0.632000													36	95					0	0	1	0	0
MIR551B	693136	broad.mit.edu	37	3	168269701	168269701	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168269701G>A	ENST00000384984.1	+	0	60					NR_030294.1																						AGAACGGGAAGGCGACCCATA	0.453000													15	49					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55143862	55143862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:55143862C>T	ENST00000491143.2	+	2	1454	c.1422C>T	c.(1420-1422)ttC>ttT	p.F474F		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	474					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		GCAACTTCTTCATGAACGCCC	0.577000													13	71					0	0	1	0	0
IL17B	27190	broad.mit.edu	37	5	148756469	148756469	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148756469C>T	ENST00000261796.3	-	2	191	c.141G>A	c.(139-141)ctG>ctA	p.L47L	IL17B_ENST00000505432.1_5'UTR	NM_014443.2	NP_055258.1	Q9UHF5	IL17B_HUMAN	interleukin 17B	47					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)|urinary_tract(1)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACCAGGTCCAGTGGCACCT	0.652000													30	81					0	0	1	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60027228	60027228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:60027228G>A	ENST00000586569.1	+	6	600	c.562G>A	c.(562-564)Gag>Aag	p.E188K	TNFRSF11A_ENST00000269485.7_Missense_Mutation_p.E188K	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	188					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				TCATGGGACAGAGAAATCCGA	0.433000													27	70					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38451527	38451527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38451527C>T	ENST00000322350.5	+	19	3000	c.2654C>T	c.(2653-2655)tCc>tTc	p.S885F	EGFLAM_ENST00000506135.1_Missense_Mutation_p.S28F|EGFLAM_ENST00000397210.3_Missense_Mutation_p.S28F|EGFLAM_ENST00000397202.2_Missense_Mutation_p.S251F|EGFLAM_ENST00000514476.1_Missense_Mutation_p.S28F|EGFLAM_ENST00000336740.6_Missense_Mutation_p.S651F|EGFLAM_ENST00000354891.3_Missense_Mutation_p.S893F	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	893	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GACTTCATTTCCTTGGGCCTT	0.517000													37	102					0	0	1	0	0
KRT6C	286887	broad.mit.edu	37	12	52865921	52865921	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52865921G>A	ENST00000252250.6	-	2	731	c.684C>T	c.(682-684)atC>atT	p.I228I		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	228	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GTTCCCCGACGATGCTGTCCA	0.597000													42	132					0	0	1	0	0
BAAT	570	broad.mit.edu	37	9	104125001	104125001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104125001G>A	ENST00000259407.2	-	4	1074	c.966C>T	c.(964-966)ttC>ttT	p.F322F	BAAT_ENST00000395051.3_Silent_p.F322F	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	322					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	CTCCTACAATGAAGAGGAATT	0.468000													32	94					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187003942	187003942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187003942C>T	ENST00000296795.2	+	4	1206	c.1102C>T	c.(1102-1104)Cca>Tca	p.P368S	TLR3_ENST00000504367.1_Missense_Mutation_p.P91S	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	368					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TAATGATATTCCAGGCATAAA	0.343000													15	36					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286905	152286905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152286905C>T	ENST00000368799.1	-	3	492	c.457G>A	c.(457-459)Gaa>Aaa	p.E153K	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	153					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAACTAGATTCATGCCTTTTC	0.348000									Ichthyosis				17	130					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16977298	16977298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16977298C>T	ENST00000379803.1	+	13	1847	c.1833C>T	c.(1831-1833)ttC>ttT	p.F611F	SIN3B_ENST00000595541.1_Silent_p.F169F|SIN3B_ENST00000248054.5_Silent_p.F579F	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	611					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						CTGTGAACTTCAAGCAGAACG	0.597000													26	84					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751374	26751374	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:26751374C>T	ENST00000396641.2	+	2	803	c.211C>T	c.(211-213)Ctg>Ttg	p.L71L	LRRC3B_ENST00000417744.1_Silent_p.L71L|LRRC3B_ENST00000456208.2_Silent_p.L71L	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	71						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						CTTACTGTATCTGGACTCCAA	0.403000													16	49					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7989454	7989454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7989454G>A	ENST00000319144.4	-	2	492	c.232C>T	c.(232-234)Ccc>Tcc	p.P78S		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	78	PLAT.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						GGGTCCTTGGGGAAGAAGGCG	0.592000										Multiple Myeloma(8;0.094)			24	26					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69817226	69817226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69817226C>T	ENST00000251566.4	-	1	283	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K		NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	85						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TCATTTTCTTCTGTTCTGTCC	0.368000													22	67					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98209303	98209303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:98209303G>A	ENST00000430669.2	-	23	4622	c.4037C>T	c.(4036-4038)cCc>cTc	p.P1346L	PTCH1_ENST00000331920.6_Missense_Mutation_p.P1412L|PTCH1_ENST00000375274.2_Missense_Mutation_p.P1411L|PTCH1_ENST00000437951.1_Missense_Mutation_p.P1346L|PTCH1_ENST00000421141.1_Missense_Mutation_p.P1261L|PTCH1_ENST00000429896.2_Missense_Mutation_p.P1261L|PTCH1_ENST00000418258.1_Missense_Mutation_p.P1261L			Q13635	PTC1_HUMAN	patched 1	1412					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AGGCACGTGGGGGTCCTCAAA	0.672000													9	96					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100594366	100594366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100594366C>T	ENST00000471714.1	-	8	933	c.824G>A	c.(823-825)gGa>gAa	p.G275E	ABI3BP_ENST00000495063.1_Missense_Mutation_p.G275E|ABI3BP_ENST00000284322.5_Missense_Mutation_p.G275E			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	275						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TATCACTCCTCCCAGTGGAGC	0.438000													15	51					0	0	1	0	0
SAMSN1	64092	broad.mit.edu	37	21	15858288	15858288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:15858288G>A	ENST00000285670.2	-	9	1445	c.1271C>T	c.(1270-1272)tCt>tTt	p.S424F	SAMSN1_ENST00000400566.1_Missense_Mutation_p.S356F|SAMSN1_ENST00000400564.1_Missense_Mutation_p.S188F	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	356					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CAGATTTTCAGACTCCAGATC	0.393000													30	140					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38281580	38281580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:38281580C>T	ENST00000553443.1	+	25	4631	c.4631C>T	c.(4630-4632)aCc>aTc	p.T1544I	TTC6_ENST00000476979.1_Missense_Mutation_p.T178I|TTC6_ENST00000382320.3_Missense_Mutation_p.T258I|TTC6_ENST00000267368.7_Missense_Mutation_p.T178I					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		AAACTAAATACCTTCCTTAAT	0.368000													31	82					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43552311	43552311	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43552311C>T	ENST00000220420.5	-	3	382	c.375G>A	c.(373-375)caG>caA	p.Q125Q	TGM5_ENST00000349114.4_Intron	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	125					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TCACAGACCCCTGGAAGGAGT	0.612000													53	75					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38753835	38753835	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38753835G>A	ENST00000449082.2	-	22	3905	c.3906C>T	c.(3904-3906)ctC>ctT	p.L1302L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1302					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCCCTGCGAAGAGGTTCACAC	0.493000													30	154					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100999520	100999520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100999520C>T	ENST00000325455.5	-	1	1735	c.282G>A	c.(280-282)agG>agA	p.R94R	PGR_ENST00000534013.1_Intron|PGR_ENST00000263463.5_Silent_p.R94R	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	94	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CTCCAGCACCCCTTGTAGCTT	0.632000													14	46					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90016011	90016011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90016011G>A	ENST00000405460.2	+	44	9690	c.9594G>A	c.(9592-9594)ggG>ggA	p.G3198G		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3198					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCCCTTTGGGGCTATTCAGTA	0.368000													17	19					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110439312	110439312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110439312G>A	ENST00000378402.5	+	25	3031	c.2927G>A	c.(2926-2928)cGa>cAa	p.R976Q		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	976					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCAGTTACACGAGAGGGAACC	0.542000										HNSCC(38;0.096)			11	62					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46094150	46094150	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46094150G>A	ENST00000323040.4	-	2	1919	c.975C>T	c.(973-975)acC>acT	p.T325T	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	325						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		AGGTGAGTGGGGTCTCCAGGG	0.662000													11	93					0	0	1	0	0
RNF220	55182	broad.mit.edu	37	1	44878220	44878220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44878220C>T	ENST00000355387.2	+	2	901	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	RNF220_ENST00000372247.2_Missense_Mutation_p.P151S|RNF220_ENST00000361799.2_Missense_Mutation_p.P151S			Q5VTB9	RN220_HUMAN	ring finger protein 220	151					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						CACAGAGTCTCCCCACTTGCG	0.562000													40	88					0	0	1	0	0
GABRD	2563	broad.mit.edu	37	1	1961512	1961512	+	Missense_Mutation	SNP	C	C	T	rs79386457	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1961512C>T	ENST00000378585.4	+	9	1233	c.1150C>T	c.(1150-1152)Ccg>Tcg	p.P384S		NM_000815.4	NP_000806.2	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	384						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GCGCCGCGTCCCGGGGAACCT	0.687000													14	38					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10080036	10080036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10080036G>A	ENST00000264828.3	-	57	4226	c.4141C>T	c.(4141-4143)Cct>Tct	p.P1381S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1381	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			AGGGGGCCAGGAGGGCCCATC	0.597000													18	47					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80645963	80645963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80645963G>A	ENST00000458043.2	+	12	1246	c.1240G>A	c.(1240-1242)Gga>Aga	p.G414R	OTOGL_ENST00000547103.1_Missense_Mutation_p.G414R	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTGTCTTGATGGATGTTACTG	0.443000													3	10					0	0	1	0	0
B3GNT2	10678	broad.mit.edu	37	2	62449618	62449618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:62449618C>T	ENST00000301998.4	+	2	515	c.263C>T	c.(262-264)tCc>tTc	p.S88F	B3GNT2_ENST00000405767.1_Missense_Mutation_p.S88F	NM_006577.5	NP_006568.2	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	88						Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)	18	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			GGCAGGCTCTCCAATATAAGC	0.547000													163	404					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25675929	25675929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25675929C>T	ENST00000382051.3	+	11	1278	c.1228C>T	c.(1228-1230)Ccc>Tcc	p.P410S	SLC34A2_ENST00000503434.1_Missense_Mutation_p.P409S|SLC34A2_ENST00000504570.1_Missense_Mutation_p.P409S	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	410					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TTTCCCCTTTCCCTTTGCATG	0.597000			T	ROS1	NSCLC								18	34					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126400967	126400967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126400967C>T	ENST00000394329.3	+	14	12558	c.12545C>T	c.(12544-12546)tCa>tTa	p.S4182L	FAT4_ENST00000335110.5_Intron	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4182	EGF-like 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GATTACTGGTCATGGCAGCAG	0.428000													17	34					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310133	57310133	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57310133G>A	ENST00000457912.1	+	2	72	c.72G>A	c.(70-72)ggG>ggA	p.G24G	SMTNL1_ENST00000527972.1_Silent_p.G6G|SMTNL1_ENST00000399154.2_Silent_p.G6G			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	6										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						AGAAGGAAGGGAAGCTCTCTG	0.597000													6	26					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216007	140216007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140216007C>T	ENST00000525929.1	+	1	2039	c.2039C>T	c.(2038-2040)tCg>tTg	p.S680L	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.S680L|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGCGTCGTCGCGGGCATCG	0.627000													28	102					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83433134	83433134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:83433134C>T	ENST00000296591.5	-	5	812	c.394G>A	c.(394-396)Gga>Aga	p.G132R	EDIL3_ENST00000380138.3_Missense_Mutation_p.G122R	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	132	EGF-like 3.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GTACATATTCCACCATTTTTG	0.358000													51	115					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2622075	2622075	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2622075G>T	ENST00000399655.1	+	9	1580	c.1315G>T	c.(1315-1317)Gat>Tat	p.D439Y	CACNA1C_ENST00000399637.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000480911.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000335762.5_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399603.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399649.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000399595.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399606.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399601.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399617.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000344100.3_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399621.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399629.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000327702.7_Missense_Mutation_p.D439Y|CACNA1C_ENST00000406454.3_Missense_Mutation_p.D439Y|CACNA1C_ENST00000402845.3_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399597.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000347598.4_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399641.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399638.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399644.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399591.1_Missense_Mutation_p.D439Y|CACNA1C_ENST00000399634.1_Missense_Mutation_p.D439Y	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	439	Binding to the beta subunit (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGGCTACCTGGATTGGATCAC	0.537000													6	14					0.00116845	0.00116969	1	1	0
COL14A1	7373	broad.mit.edu	37	8	121262978	121262978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121262978G>A	ENST00000297848.3	+	22	2995	c.2725G>A	c.(2725-2727)Gac>Aac	p.D909N	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.D814N|COL14A1_ENST00000309791.4_Missense_Mutation_p.D909N	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	909	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AGGCTTCAGCGACGCCCTGAC	0.478000													10	47					0	0	1	0	0
WNT1	7471	broad.mit.edu	37	12	49373260	49373260	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49373260G>A	ENST00000293549.3	+	2	150	c.114G>A	c.(112-114)gtG>gtA	p.V38V		NM_005430.3	NP_005421.1	P04628	WNT1_HUMAN	wingless-type MMTV integration site family, member 1	38					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(357;0.244)		GGGGTATTGTGAACGTAGCCT	0.567000													44	101					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113953812	113953812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113953812G>A	ENST00000245796.6	+	12	2509	c.2314G>A	c.(2314-2316)Gat>Aat	p.D772N	PSD4_ENST00000441564.2_Missense_Mutation_p.D744N	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	772					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCTGGCTCAGGATCCCACAGT	0.567000													16	45					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72345460	72345460	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72345460G>A	ENST00000389916.4	+	10	1323	c.1185G>A	c.(1183-1185)caG>caA	p.Q395Q		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	395					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GGGGCCGGCAGGATCGGGGTG	0.662000													12	17					0	0	1	0	0
KRTAP10-7	386675	broad.mit.edu	37	21	46021535	46021535	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46021535C>T	ENST00000380102.2	+	1	1039	c.1014C>T	c.(1012-1014)tcC>tcT	p.S338S	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	338	30 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						CCCCCACCTCCTCCTGCCAGG	0.716000													22	69					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74943984	74943984	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74943984A>G	ENST00000569840.2	+	17	2570	c.1996A>G	c.(1996-1998)Aat>Gat	p.N666D	MGAT5B_ENST00000301618.4_Missense_Mutation_p.N664D|MGAT5B_ENST00000428789.2_Missense_Mutation_p.N675D	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	666						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCTGGCCCCCAATGCCACCCA	0.711000													8	25					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85401165	85401165	+	Missense_Mutation	SNP	C	C	T	rs139722212		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85401165C>T	ENST00000258888.5	+	6	3969	c.3802C>T	c.(3802-3804)Ccc>Tcc	p.P1268S		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1268					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGGTCCTGGTCCCAGCTCCCT	0.687000													6	19					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152057759	152057759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152057759G>A	ENST00000368806.1	-	3	2463	c.2399C>T	c.(2398-2400)cCa>cTa	p.P800L		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	800							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CTGGTATAGTGGACTGGAATA	0.488000													50	123					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595325	140595325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140595325G>A	ENST00000341948.4	+	1	1817	c.1630G>A	c.(1630-1632)Gag>Aag	p.E544K		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		544	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGAGCAGCGAGGCGCTGGT	0.701000													32	71					0	0	1	0	0
PLS1	5357	broad.mit.edu	37	3	142405204	142405204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142405204C>T	ENST00000337777.3	+	9	1180	c.967C>T	c.(967-969)Ctt>Ttt	p.L323F	PLS1_ENST00000457734.2_Missense_Mutation_p.L323F|PLS1_ENST00000497002.1_Missense_Mutation_p.L323F	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	323	Actin-binding 1.|CH 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						TGCCATTGACCTTTCAGGAAT	0.348000													28	118					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41979410	41979410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:41979410C>T	ENST00000372584.1	-	7	6496	c.5482G>A	c.(5482-5484)Gac>Aac	p.D1828N	HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000247584.5_Missense_Mutation_p.D1828N|HIVEP3_ENST00000372583.1_Missense_Mutation_p.D1828N|HIVEP3_ENST00000429157.2_Missense_Mutation_p.D1828N	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1828	Acidic 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGAACAGGTCGTCACTGGTT	0.597000													9	33					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196295998	196295998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196295998C>T	ENST00000367433.5	-	19	2226	c.2125G>A	c.(2125-2127)Gag>Aag	p.E709K	KCNT2_ENST00000498426.1_Intron|KCNT2_ENST00000451324.2_Missense_Mutation_p.E320K|KCNT2_ENST00000367431.4_Missense_Mutation_p.E659K|KCNT2_ENST00000294725.8_Missense_Mutation_p.E709K			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	709						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TTTGCATCCTCATAGTAGTTA	0.318000													42	102					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116073768	116073768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116073768C>T	ENST00000369271.3	-	7	954	c.654G>A	c.(652-654)gtG>gtA	p.V218V	AFAP1L2_ENST00000545353.1_Silent_p.V271V|AFAP1L2_ENST00000304129.4_Silent_p.V218V	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	218	PH 1.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		CCAGTAGGTTCACGTCCAGCT	0.552000													18	57					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196716443	196716443	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196716443G>A	ENST00000367429.4	+	22	3936	c.3696G>A	c.(3694-3696)taG>taA	p.*1232*		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	0					complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						CAAAAAGATAGAATCAATCAT	0.338000													20	56					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116198974	116198974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116198974C>T	ENST00000369252.4	-	21	2224	c.1923G>A	c.(1921-1923)atG>atA	p.M641I	ABLIM1_ENST00000369266.3_Missense_Mutation_p.M378I|ABLIM1_ENST00000277895.5_Missense_Mutation_p.M701I|ABLIM1_ENST00000369253.2_Missense_Mutation_p.M324I|ABLIM1_ENST00000533213.2_Missense_Mutation_p.M641I|ABLIM1_ENST00000392952.3_Missense_Mutation_p.M378I	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	701					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CTCCTCGGTCCATTCTCATTG	0.473000													18	55					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130501159	130501159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130501159C>T	ENST00000314830.8	-	12	2562	c.2449G>A	c.(2449-2451)Gag>Aag	p.E817K	SH2D3C_ENST00000429553.1_Missense_Mutation_p.E463K|SH2D3C_ENST00000373274.3_Missense_Mutation_p.E657K|SH2D3C_ENST00000420366.1_Missense_Mutation_p.E659K|SH2D3C_ENST00000373277.4_Missense_Mutation_p.E660K|SH2D3C_ENST00000373276.3_Missense_Mutation_p.E749K	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	817	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						ATCTGGAACTCCGTGCTGAAC	0.647000													4	8					0	0	1	0	0
GPR4	2828	broad.mit.edu	37	19	46094548	46094548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46094548G>A	ENST00000323040.4	-	2	1521	c.577C>T	c.(577-579)Ccg>Tcg	p.P193S	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	193						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		AGCGCCCACGGGAAGAGGAAG	0.642000													15	62					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100373312	100373312	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100373312C>T	ENST00000542585.1	+	0	6194				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACAGGTCACCCTCCCCGCCAT	0.567000													16	59					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154414531	154414531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:154414531C>T	ENST00000229768.5	+	4	1341	c.1291C>T	c.(1291-1293)Cgt>Tgt	p.R431C	OPRM1_ENST00000419506.2_Intron|OPRM1_ENST00000452687.2_Intron|OPRM1_ENST00000435918.2_Intron|OPRM1_ENST00000434900.2_Intron|OPRM1_ENST00000520708.1_Intron|OPRM1_ENST00000522236.1_Intron|OPRM1_ENST00000518759.1_Intron|OPRM1_ENST00000414028.2_Intron|OPRM1_ENST00000330432.7_Intron|OPRM1_ENST00000524163.1_Intron|OPRM1_ENST00000360422.4_Intron|OPRM1_ENST00000337049.4_Intron|OPRM1_ENST00000522555.1_Intron	NM_001008505.1	NP_001008505.2	P35372	OPRM_HUMAN	opioid receptor, mu 1	0					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	GTCCTGCCTTCGTGGAAATAC	0.527000													43	146					0	0	1	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15444301	15444301	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:15444301T>A	ENST00000295297.4	+	3	1028	c.769T>A	c.(769-771)Ttc>Atc	p.F257I	C1QTNF7_ENST00000429690.1_Missense_Mutation_p.F250I|C1QTNF7_ENST00000444304.2_Missense_Mutation_p.F250I	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	250	C1q.					collagen				endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						GCTGGAGATTTTCTTCACAGA	0.493000													54	94					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42458807	42458807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42458807G>A	ENST00000318006.5	-	15	1722	c.1560C>T	c.(1558-1560)tcC>tcT	p.S520S	VPS39_ENST00000348544.4_Silent_p.S531S	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	531					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		CTTTCAGAGGGGAGTTGGCTT	0.547000													21	51					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47379846	47379846	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47379846T>A	ENST00000285039.7	-	31	4493	c.4194A>T	c.(4192-4194)gaA>gaT	p.E1398D	MYO5B_ENST00000324581.6_Missense_Mutation_p.E513D	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1398					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GCCGGGATATTTCCTGCTGAA	0.567000													20	67					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107938511	107938511	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107938511G>A	ENST00000328300.6	+	52	5080	c.4836G>A	c.(4834-4836)ggG>ggA	p.G1612G	COL4A5_ENST00000361603.2_Silent_p.G1606G	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1606	Collagen IV NC1.		Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						CAAGTGCAGGGGCAGAAGGCT	0.493000									Alport syndrome with Diffuse Leiomyomatosis				16	77					0	0	1	0	0
CXCL12	6387	broad.mit.edu	37	10	44873247	44873247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:44873247G>A	ENST00000395794.2	-	4	416	c.373C>T	c.(373-375)Cgt>Tgt	p.R125C	CXCL12_ENST00000395795.4_Intron|CXCL12_ENST00000395793.3_Intron|CXCL12_ENST00000343575.6_3'UTR|CXCL12_ENST00000374429.2_Intron|CXCL12_ENST00000374426.2_Intron	NM_001178134.1	NP_001171605.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	0					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	GGCCAAAGACGGATCTCACAG	0.612000													8	19					0	0	1	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98677961	98677961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:98677961C>T	ENST00000288985.7	+	5	1138	c.833C>T	c.(832-834)tCa>tTa	p.S278L	ERCC6L2_ENST00000466840.1_3'UTR|ERCC6L2_ENST00000437817.1_Missense_Mutation_p.S89L	NM_001010895.2	NP_001010895.1	Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	278	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding										TTGGAATGGTCAGCTGTCATT	0.363000													17	96					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17789545	17789545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:17789545G>A	ENST00000380607.4	+	6	741	c.621G>A	c.(619-621)atG>atA	p.M207I	SH3GL2_ENST00000537391.1_Missense_Mutation_p.M160I	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	207	BAR.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		TCTTGGAGATGGATGTAAGTG	0.373000													11	72					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801491	185801491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185801491C>T	ENST00000302277.6	+	4	1962	c.1368C>T	c.(1366-1368)agC>agT	p.S456S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	456						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTTCCTATAGCTGTAATCCTC	0.353000													40	108					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33920725	33920725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33920725C>T	ENST00000389232.4	+	21	2698	c.2628C>T	c.(2626-2628)atC>atT	p.I876I	RYR3_ENST00000415757.3_Silent_p.I876I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	876	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGAAAACATCCATGAGCTTT	0.443000													17	67					0	0	1	0	0
ANKRD10	55608	broad.mit.edu	37	13	111546503	111546503	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111546503G>A	ENST00000375758.5	-	4	636	c.502C>T	c.(502-504)Caa>Taa	p.Q168*	ANKRD10_ENST00000489973.2_5'UTR|ANKRD10_ENST00000310847.4_Nonsense_Mutation_p.Q168*|ANKRD10_ENST00000267339.2_Intron			Q9NXR5	ANR10_HUMAN	ankyrin repeat domain 10	0										central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)	9	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		all cancers(43;0.0882)|BRCA - Breast invasive adenocarcinoma(86;0.188)|Lung(89;0.208)			ACTCCATGTTGAAGTTCCCCT	0.383000													36	88					0	0	1	0	0
IFNA14	3448	broad.mit.edu	37	9	21239751	21239751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21239751G>A	ENST00000380222.2	-	1	227	c.184C>T	c.(184-186)Ccc>Tcc	p.P62S		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	62					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TCCTCCTGGGGAAATTCAAAG	0.468000													67	106					0	0	1	0	0
PWWP2B	170394	broad.mit.edu	37	10	134218356	134218356	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134218356C>T	ENST00000305233.5	+	2	411	c.352C>T	c.(352-354)Cct>Tct	p.P118S	PWWP2B_ENST00000368609.4_Missense_Mutation_p.P118S	NM_138499.3	NP_612508.3	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2B	118	Pro-rich.									central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GCCCCCGTACCCTCCCTACTT	0.756000													17	20					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131186724	131186724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:131186724G>A	ENST00000337057.3	-	17	2962	c.2781C>T	c.(2779-2781)acC>acT	p.T927T	EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000525193.1_Silent_p.T628T|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000531410.1_Silent_p.T48T|EPB41L2_ENST00000527659.1_Silent_p.T733T|EPB41L2_ENST00000528282.1_Silent_p.T669T|EPB41L2_ENST00000530481.1_Silent_p.T774T|EPB41L2_ENST00000445890.2_Silent_p.T669T|EPB41L2_ENST00000524581.1_Silent_p.T305T|EPB41L2_ENST00000527411.1_Silent_p.T857T|EPB41L2_ENST00000368128.2_Silent_p.T927T|EPB41L2_ENST00000529208.1_Silent_p.T857T	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	927	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CAGATGTGATGGTTTGTGCGG	0.458000													19	47					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327032	52327032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52327032G>A	ENST00000339223.4	+	2	210	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K	FPR3_ENST00000595991.1_Missense_Mutation_p.E11K	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	11					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TCCTCTGAATGAAACTGAGGA	0.493000													22	42					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12483637	12483637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:12483637G>A	ENST00000535902.1	-	4	1183	c.620C>T	c.(619-621)tCa>tTa	p.S207L	MANSC1_ENST00000396349.3_Missense_Mutation_p.S173L|MANSC1_ENST00000545735.1_Missense_Mutation_p.S126L			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	207						integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		GGAAAATTGTGAACTCTGAGA	0.463000													20	51					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34125657	34125657	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34125657G>A	ENST00000297161.2	+	14	2072	c.1698G>A	c.(1696-1698)tgG>tgA	p.W566*	BMPER_ENST00000426693.1_Nonsense_Mutation_p.W566*	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	566	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						TCAAATCCTGGGAGTTTCAGA	0.502000													22	56					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3342181	3342181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3342181G>A	ENST00000378398.3	+	14	3058	c.2976G>A	c.(2974-2976)tcG>tcA	p.S992S	PRDM16_ENST00000378391.2_Silent_p.S992S|PRDM16_ENST00000270722.5_Silent_p.S992S|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Silent_p.S991S|PRDM16_ENST00000441472.2_Silent_p.S991S|PRDM16_ENST00000514189.1_Silent_p.S992S|PRDM16_ENST00000511072.1_Silent_p.S993S			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	992	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCATCTCTTCGAACCTCCAGC	0.632000			T	EVI1	"""MDS, AML"""								35	76					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135429948	135429948	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135429948G>A	ENST00000394143.1	+	6	4374	c.4083G>A	c.(4081-4083)ggG>ggA	p.G1361G	GPR112_ENST00000370652.1_Silent_p.G1361G|GPR112_ENST00000287534.4_Silent_p.G1298G|GPR112_ENST00000394141.1_Silent_p.G1156G|GPR112_ENST00000412101.1_Silent_p.G1156G	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1361					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CCAGTCTTGGGAAAACAGCTC	0.478000													22	110					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64662882	64662882	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64662882G>A	ENST00000421419.2	-	40	5580	c.5466C>T	c.(5464-5466)tcC>tcT	p.S1822S	ATG2A_ENST00000377264.3_Silent_p.S1820S			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1820							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						GGGCTGCCGGGGACAGGATGT	0.701000													5	10					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949180	27949180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27949180G>A	ENST00000379992.2	-	6	1939	c.1490C>T	c.(1489-1491)tCc>tTc	p.S497F	LINGO2_ENST00000308675.3_Missense_Mutation_p.S497F	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	497	Ig-like C2-type.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CACAGTTAAGGAGGCTGTGAA	0.483000													20	84					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43106982	43106982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43106982G>A	ENST00000230419.4	+	9	1692	c.1471G>A	c.(1471-1473)Gag>Aag	p.E491K	PTK7_ENST00000481273.1_Missense_Mutation_p.E499K|PTK7_ENST00000345201.2_Missense_Mutation_p.E491K|PTK7_ENST00000349241.2_Intron|PTK7_ENST00000352931.2_Missense_Mutation_p.E491K	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	491	Ig-like C2-type 5.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CGGCAGCATCGAGGCGCAAGC	0.607000													20	34					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79939559	79939559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:79939559G>A	ENST00000373275.4	-	37	4399	c.4183C>T	c.(4183-4185)Cgc>Tgc	p.R1395C	BRWD3_ENST00000473691.1_Intron	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1395	Bromo 2.									breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						AATATTTGGCGAACATCCTTA	0.348000													11	42					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43771946	43771946	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43771946G>A	ENST00000244293.7	-	2	486	c.420C>T	c.(418-420)ttC>ttT	p.F140F	PSG9_ENST00000443718.3_Silent_p.F140F|PSG9_ENST00000418820.2_Silent_p.F140F|PSG9_ENST00000270077.3_Silent_p.F140F|PSG9_ENST00000596730.1_Silent_p.F140F|PSG9_ENST00000593948.1_Silent_p.F140F|PSG9_ENST00000291752.5_Silent_p.F140F			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	140	Ig-like V-type.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGTATAAGGTGAAGGTGAAAT	0.488000													77	209					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142505555	142505555	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142505555C>T	ENST00000430863.1	-	0	371					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		CAGCACTGTTCATGTCCTGCA	0.532000													18	41					0	0	1	0	0
ZNF578	147660	broad.mit.edu	37	19	53015326	53015326	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53015326G>A	ENST00000421239.2	+	6	1936	c.1692G>A	c.(1690-1692)gaG>gaA	p.E564E	CTD-3099C6.5_ENST00000599143.1_RNA	NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATAGCGGAGAGAAACCTTACA	0.393000													26	68					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7320910	7320910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7320910C>T	ENST00000302926.2	+	7	2373	c.2300C>T	c.(2299-2301)cCc>cTc	p.P767L	NLGN2_ENST00000575301.1_Missense_Mutation_p.P767L	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	767					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				GCCTGCCCGCCCGACTACACC	0.746000													3	4					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56320147	56320147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56320147C>T	ENST00000443188.1	-	5	2539	c.1829G>A	c.(1828-1830)aGg>aAg	p.R610K	NLRP11_ENST00000589824.2_Missense_Mutation_p.R610K|NLRP11_ENST00000592953.1_Missense_Mutation_p.R511K|NLRP11_ENST00000589093.1_Missense_Mutation_p.R610K|NLRP11_ENST00000360133.3_Missense_Mutation_p.R610K	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	610							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AGCAGTTGGCCTTATAAGTGG	0.408000													37	102					0	0	1	0	0
CA4	762	broad.mit.edu	37	17	58234891	58234891	+	Silent	SNP	G	G	A	rs145588553	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58234891G>A	ENST00000300900.4	+	4	471	c.372G>A	c.(370-372)aaG>aaA	p.K124K		NM_000717.3	NP_000708.1	P22748	CAH4_HUMAN	carbonic anhydrase IV	124					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(5)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TGCCATATAAGGGCTCGGAGC	0.612000													42	170					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40852889	40852889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:40852889C>T	ENST00000254691.5	+	3	1654	c.1455C>T	c.(1453-1455)atC>atT	p.I485I	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	485					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TACACAAAATCTTTCTTCATC	0.443000													18	72					0	0	1	0	0
FSD1	79187	broad.mit.edu	37	19	4323544	4323544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4323544C>T	ENST00000597590.1	+	13	1375	c.1304C>T	c.(1303-1305)gCt>gTt	p.A435V	FSD1_ENST00000221856.6_Silent_p.S465S			Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	0	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGTGGCAGCTTCCAGGTGA	0.682000													12	20					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529187	57529187	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57529187G>A	ENST00000420713.1	+	4	1132	c.1020G>A	c.(1018-1020)aaG>aaA	p.K340K		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						CAACCCTTAAGAAACATAAGA	0.398000													15	39					0	0	1	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58190262	58190262	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58190262G>A	ENST00000318203.5	+	5	1988	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	431					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTCCACACCAGAAGCTTCCTA	0.398000													22	99					0	0	1	0	0
PPIL3	53938	broad.mit.edu	37	2	201746149	201746149	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:201746149G>A	ENST00000286175.8	-	5	630	c.247C>T	c.(247-249)Ctt>Ttt	p.L83F	PPIL3_ENST00000465823.1_5'UTR|PPIL3_ENST00000409361.1_Missense_Mutation_p.L75F|PPIL3_ENST00000392283.4_Missense_Mutation_p.L79F|PPIL3_ENST00000409449.1_Missense_Mutation_p.L83F	NM_032472.3	NP_115861.1	Q9H2H8	PPIL3_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 3	79	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity|protein binding			endometrium(1)|lung(2)	3						TTTACCTTAAGATATTCACTG	0.338000													20	37					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280433	152280433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152280433G>A	ENST00000368799.1	-	3	6964	c.6929C>T	c.(6928-6930)tCc>tTc	p.S2310F	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2310	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCACCAGAGGAATTCTCTGC	0.567000									Ichthyosis				173	496					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50048801	50048801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50048801G>A	ENST00000371564.3	-	9	2744	c.2525C>T	c.(2524-2526)aCc>aTc	p.T842I	NFATC2_ENST00000414705.1_Missense_Mutation_p.T822I|NFATC2_ENST00000396009.3_Missense_Mutation_p.T842I	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	842					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GCCAGGTCTGGTGGTGCCTGG	0.617000													10	74					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21926377	21926377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21926377C>T	ENST00000240662.2	-	2	519	c.174G>A	c.(172-174)caG>caA	p.Q58Q		NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	58						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	TGAAGATGTCCTGTAGAAAGC	0.582000											OREG0021704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	62					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134920414	134920414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134920414G>A	ENST00000398015.3	+	12	2599	c.2229G>A	c.(2227-2229)cgG>cgA	p.R743R	EPHB1_ENST00000493838.1_Silent_p.R304R	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	743	Protein kinase.		R -> Q (in a gastric adenocarcinoma sample; somatic mutation).			integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						ATGTGCATCGGGACCTGGCTG	0.547000													53	161					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795341	142795341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142795341C>T	ENST00000370498.1	-	2	1090	c.337G>A	c.(337-339)Gaa>Aaa	p.E113K		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	113										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGGTCTTCGTCCTCCTGT	0.532000													18	241					0	0	1	0	0
PBLD	64081	broad.mit.edu	37	10	70044033	70044033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70044033G>A	ENST00000358769.2	-	10	970	c.768C>T	c.(766-768)tcC>tcT	p.S256S	PBLD_ENST00000309049.4_Silent_p.S256S|PBLD_ENST00000336578.1_Silent_p.S223S	NM_022129.3	NP_071412.2	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing	256					biosynthetic process		isomerase activity			endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						CTCCTCGGTGGGAACACTGAA	0.413000													6	68					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069622	9069622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9069622G>A	ENST00000397910.4	-	3	18027	c.17824C>T	c.(17824-17826)Ctt>Ttt	p.L5942F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5944	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCGGAATAAAGAGATGAATGT	0.502000													15	48					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122756816	122756816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:122756816G>A	ENST00000227349.2	+	2	556	c.259G>A	c.(259-261)Gag>Aag	p.E87K	C11orf63_ENST00000307257.6_Missense_Mutation_p.E87K|C11orf63_ENST00000531316.1_Missense_Mutation_p.E87K	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	87										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AAGCCTGCACGAGATGGAAGA	0.537000													31	105					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39884993	39884993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39884993G>A	ENST00000260356.5	+	17	2922	c.2757G>A	c.(2755-2757)aaG>aaA	p.K919K		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	919					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CCGACCAGAAGGACTCTGACG	0.502000													7	39					0	0	1	0	0
CLDN8	9073	broad.mit.edu	37	21	31588019	31588019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31588019C>T	ENST00000399899.1	-	1	372	c.225G>A	c.(223-225)ccG>ccA	p.P75P	CLDN8_ENST00000286809.1_Silent_p.P75P	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	75					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						CCTGTAGGTCCGGAGAAAGAG	0.507000													35	72					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13098373	13098373	+	Splice_Site	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:13098373G>T	ENST00000399002.2	+	8	1426		c.e8+1		SPTLC3_ENST00000378194.4_Intron	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3						sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	TGGAAGGAAGGTAAGAGAGGG	0.483000													13	71					9.31168e-06	9.33056e-06	1	1	0
CACNA2D4	93589	broad.mit.edu	37	12	2022194	2022194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2022194C>T	ENST00000382722.5	-	3	783	c.421G>A	c.(421-423)Gtc>Atc	p.V141I	CACNA2D4_ENST00000586184.1_Missense_Mutation_p.V141I|CACNA2D4_ENST00000585732.1_Missense_Mutation_p.V141I|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.V77I|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.V141I|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.V77I	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	141						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity	p.V141I(2)		endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AGTACCTGGACCGCCTCGACT	0.602000													4	19					0	0	1	0	0
WRB	7485	broad.mit.edu	37	21	40765134	40765134	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:40765134C>T	ENST00000333781.5	+	4	520	c.379C>T	c.(379-381)Cct>Tct	p.P127S	WRB_ENST00000541890.1_Missense_Mutation_p.P127S|WRB_ENST00000380708.1_Missense_Mutation_p.P93S|WRB_ENST00000466787.1_3'UTR|WRB_ENST00000398753.1_Missense_Mutation_p.P93S	NM_004627.4	NP_004618.2	O00258	WRB_HUMAN	tryptophan rich basic protein	127						integral to membrane|nucleolus				endometrium(3)	3		Prostate(19;1.2e-06)				TTATTCTGTCCCTGTGGCTGT	0.498000													22	64					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116046221	116046221	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116046221C>T	ENST00000603594.1	+	11	1842	c.1521C>T	c.(1519-1521)ttC>ttT	p.F507F	VWA2_ENST00000392982.3_Silent_p.F507F	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	507	VWFA 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		AGGATCTGTTCAACCAAATCC	0.627000													13	49					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54946752	54946752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54946752G>A	ENST00000301194.4	+	11	1278	c.1156G>A	c.(1156-1158)Gaa>Aaa	p.E386K	TTYH1_ENST00000376530.3_Missense_Mutation_p.E386K|TTYH1_ENST00000376531.3_Missense_Mutation_p.E386K|TTYH1_ENST00000489425.1_3'UTR|TTYH1_ENST00000391739.3_Missense_Mutation_p.416_416insQ			Q9H313	TTYH1_HUMAN	tweety family member 1	386					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GGGCCTGTGCGAAGACGCCCT	0.677000													18	46					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21690081	21690081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21690081G>A	ENST00000261195.2	-	16	2173	c.1919C>T	c.(1918-1920)tCc>tTc	p.S640F		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	640					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TGGTACTGAGGAAGGCCTGGG	0.443000													15	41					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316938	30316938	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30316938C>T	ENST00000375377.1	-	3	2240	c.2139G>A	c.(2137-2139)ccG>ccA	p.P713P		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	713										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CTGCACGACTCGGCCCTCCCA	0.572000													19	45					0	0	1	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206725	142206725	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142206725G>A	ENST00000426318.2	-	0	180																											CTCCAAGTCTGGTGACACATC	0.483000													50	94					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169812155	169812155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169812155G>A	ENST00000335742.7	+	12	2930	c.1573G>A	c.(1573-1575)Gac>Aac	p.D525N	CBR4_ENST00000509108.1_Intron|PALLD_ENST00000512127.1_Missense_Mutation_p.D301N|PALLD_ENST00000261509.6_Missense_Mutation_p.D683N|PALLD_ENST00000507735.1_Missense_Mutation_p.D196N|PALLD_ENST00000505667.1_Missense_Mutation_p.D683N			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	907	Ig-like C2-type 2.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TGTTATTCAAGACCTGGAACG	0.463000									Pancreatic Cancer, Familial Clustering of				27	58					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82321756	82321756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:82321756C>T	ENST00000376520.4	+	11	1706	c.878C>T	c.(877-879)cCa>cTa	p.P293L	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000265284.6_Missense_Mutation_p.P268L|TLE4_ENST00000376544.3_Intron|TLE4_ENST00000376552.2_Missense_Mutation_p.P293L|TLE4_ENST00000376537.4_Missense_Mutation_p.P293L			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CCGATTAGTCCAGCCTCTATT	0.527000													65	158					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20442548	20442548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20442548G>A	ENST00000331849.4	+	10	1360	c.1213G>A	c.(1213-1215)Gat>Aat	p.D405N		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	405					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CCAGATTGTGGATGATGAGGG	0.552000													11	102					0	0	1	0	0
HTR3E	285242	broad.mit.edu	37	3	183823084	183823084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183823084G>A	ENST00000415389.2	+	6	1055	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	HTR3E_ENST00000436361.2_Missense_Mutation_p.E197K|HTR3E_ENST00000440596.2_Missense_Mutation_p.E223K|HTR3E_ENST00000425359.2_Missense_Mutation_p.E182K|HTR3E_ENST00000335304.2_Missense_Mutation_p.E212K	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	197						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CATGGAGAAAGAAGTGTGGGA	0.498000													16	46					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179633587	179633587	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179633587C>T	ENST00000589042.1	-	38	9200	c.8976G>A	c.(8974-8976)gtG>gtA	p.V2992V	TTN_ENST00000342992.6_Silent_p.V2992V|TTN_ENST00000360870.5_Silent_p.V2992V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.V2946V|TTN_ENST00000342175.6_Silent_p.V2946V|TTN_ENST00000359218.5_Silent_p.V2946V|TTN_ENST00000591111.1_Silent_p.V2992V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2730	Ig-like 17.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCATAGTTCACTGTCACCT	0.388000													14	54					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8758078	8758078	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8758078C>T	ENST00000229335.6	-	3	263	c.160G>A	c.(160-162)Ggc>Agc	p.G54S	AICDA_ENST00000537228.1_Missense_Mutation_p.G54S	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	54					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					ACGTGGCAGCCGTTCTGGAGA	0.557000													15	47					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113950885	113950885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113950885G>A	ENST00000245796.6	+	8	2165	c.1970G>A	c.(1969-1971)cGa>cAa	p.R657Q	PSD4_ENST00000441564.2_Missense_Mutation_p.R629Q	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	657	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GAACGGGAGCGAATCCTCTAC	0.607000													27	68					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602980	138602980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138602980C>T	ENST00000440172.1	-	2	1440	c.1392G>A	c.(1390-1392)atG>atA	p.M464I	KIAA1549_ENST00000422774.1_Missense_Mutation_p.M464I|KIAA1549_ENST00000242365.4_Missense_Mutation_p.M414I	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	464						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CGACGCTACTCATTAGAGAGA	0.493000			O	BRAF	pilocytic astrocytoma								18	51					0	0	1	0	0
POLN	353497	broad.mit.edu	37	4	2132987	2132987	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:2132987G>A	ENST00000511885.2	-	17	2115	c.1762C>T	c.(1762-1764)Cag>Tag	p.Q588*	POLN_ENST00000382865.1_Nonsense_Mutation_p.Q588*			Q7Z5Q5	DPOLN_HUMAN	polymerase (DNA directed) nu	588					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(2)|skin(4)|urinary_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			GTAGTAATCTGAATTGGGTGC	0.343000								DNA polymerases (catalytic subunits)					8	95					0	0	1	0	0
SLC16A3	9123	broad.mit.edu	37	17	80193902	80193902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80193902G>A	ENST00000581287.1	+	1	2340	c.18G>A	c.(16-18)gtG>gtA	p.V6V	SLC16A3_ENST00000584781.1_3'UTR|SLC16A3_ENST00000392339.1_Silent_p.V6V|SLC16A3_ENST00000392341.1_Silent_p.V6V|SLC16A3_ENST00000582743.1_Silent_p.V6V	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	6					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	GGGCCGTGGTGGACGAGGGCC	0.672000													12	21					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154284938	154284938	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154284938G>A	ENST00000285873.7	-	17	2569	c.2494C>T	c.(2494-2496)Cca>Tca	p.P832S		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	832					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TTCTCTTTTGGTGGCTCCTTT	0.338000													24	85					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82444475	82444475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:82444475G>A	ENST00000268206.7	-	18	2488	c.2320C>T	c.(2320-2322)Cgt>Tgt	p.R774C	EFTUD1_ENST00000359445.3_Missense_Mutation_p.R723C	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	774					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						TCCATAGAACGAATCAAATCA	0.418000													25	91					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175742	159175742	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159175742G>A	ENST00000537147.1	+	3	1356	c.513G>A	c.(511-513)gtG>gtA	p.V171V	DARC_ENST00000368121.2_Silent_p.V173V|DARC_ENST00000368122.2_Silent_p.V171V			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	171					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					GGCTCACTGTGGGAATTTGGG	0.632000													5	24					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48597980	48597980	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48597980G>A	ENST00000537810.1	-	14	1677	c.1073C>T	c.(1072-1074)tCt>tTt	p.S358F	FRYL_ENST00000503238.1_Missense_Mutation_p.S358F|FRYL_ENST00000506685.1_Missense_Mutation_p.S64F|FRYL_ENST00000358350.4_Missense_Mutation_p.S358F|FRYL_ENST00000507711.1_Missense_Mutation_p.S358F|FRYL_ENST00000264319.7_5'UTR			O94915	FRYL_HUMAN	FRY-like	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.S358C(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						TCTATACAAAGATTCCAGTGC	0.284000													8	31					0	0	1	0	0
PAPL	390928	broad.mit.edu	37	19	39576015	39576015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39576015C>T	ENST00000331256.5	+	2	380	c.106C>T	c.(106-108)Cat>Tat	p.H36Y	PAPL_ENST00000594229.1_Missense_Mutation_p.H36Y	NM_001004318.2	NP_001004318.2	Q6ZNF0	PAPL_HUMAN		36						extracellular region	acid phosphatase activity|metal ion binding										AGAGCAAGTCCATCTGTCTTA	0.582000													36	116					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127611766	127611766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127611766C>T	ENST00000508053.1	-	65	8532	c.7558G>A	c.(7558-7560)Ggg>Agg	p.G2520R	FBN2_ENST00000262464.4_Missense_Mutation_p.G2520R			P35556	FBN2_HUMAN	fibrillin 2	2520	EGF-like 42; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGGACATACCCCCTCGGACAT	0.433000													31	148					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54364942	54364942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:54364942G>A	ENST00000306888.2	-	4	807	c.556C>T	c.(556-558)Ccc>Tcc	p.P186S	LNX1-AS1_ENST00000502373.1_RNA|FIP1L1_ENST00000507166.1_Intron|LNX1_ENST00000263925.7_Missense_Mutation_p.P282S	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	282						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			CTTTCACTGGGATCTACTCGA	0.443000													26	55					0	0	1	0	0
ALAD	210	broad.mit.edu	37	9	116155791	116155791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116155791G>A	ENST00000409155.3	-	2	245	c.49C>T	c.(49-51)Cgg>Tgg	p.R17W	ALAD_ENST00000277315.5_Missense_Mutation_p.R17W	NM_000031.5	NP_000022.3	P13716	HEM2_HUMAN	aminolevulinate dehydratase	17					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|stomach(1)	9					Aminolevulinic acid(DB00855)	TGCCAGGCCCGAAGTAGTGGG	0.617000													13	46					0	0	1	0	0
OR7C1	26664	broad.mit.edu	37	19	14910370	14910370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14910370G>A	ENST00000248073.2	-	1	653	c.579C>T	c.(577-579)ttC>ttT	p.F193F	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	193					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						CGTTATTAATGAAGGTGTCAG	0.398000													14	148					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765360	18765360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18765360G>A	ENST00000304081.4	-	5	985	c.885C>T	c.(883-885)ttC>ttT	p.F295F	NT5C1B-RDH14_ENST00000532967.1_Silent_p.F355F|NT5C1B_ENST00000600945.1_Silent_p.F355F|NT5C1B_ENST00000359846.2_Silent_p.F355F	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				ATACCTTGACGAAGCGGAACG	0.572000													31	119					0	0	1	0	0
KCNIP2	30819	broad.mit.edu	37	10	103603287	103603287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103603287G>A	ENST00000358038.3	-	1	390	c.39C>T	c.(37-39)tcC>tcT	p.S13S	KCNIP2_ENST00000355657.2_5'UTR|KCNIP2_ENST00000356640.2_Silent_p.S13S|KCNIP2_ENST00000370046.1_Silent_p.S13S|KCNIP2_ENST00000461105.1_Silent_p.S13S|KCNIP2_ENST00000343195.4_Silent_p.S13S|KCNIP2_ENST00000353068.3_Silent_p.S13S	NM_173192.2|NM_173193.2|NM_173195.2	NP_775284.1|NP_775285.1|NP_775287.1	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2	13					clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		CCAGGTCTCGGGAATCGGACA	0.726000													5	12					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8670542	8670542	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8670542G>A	ENST00000270328.4	-	2	320	c.54C>T	c.(52-54)ctC>ctT	p.L18L	ADAMTS10_ENST00000597188.1_Silent_p.L18L|ADAMTS10_ENST00000596709.1_Intron			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	18					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CCTCGAACATGAGGCCCAGCC	0.657000													10	18					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139193282	139193282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139193282G>A	ENST00000274710.3	+	3	965	c.760G>A	c.(760-762)Ggc>Agc	p.G254S		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	254					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCCCTCAGGGCCCAGGGGG	0.622000													9	20					0	0	1	0	0
NR1H2	7376	broad.mit.edu	37	19	50881015	50881015	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50881015C>T	ENST00000253727.5	+	4	304	c.69C>T	c.(67-69)gcC>gcT	p.A23A	NR1H2_ENST00000411902.2_Silent_p.A23A|NR1H2_ENST00000542413.1_5'UTR|NR1H2_ENST00000598168.1_Silent_p.A23A|NR1H2_ENST00000599105.1_Silent_p.A23A|NR1H2_ENST00000593926.1_Silent_p.A23A	NM_007121.5	NP_009052.3	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	23					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AGCCTGGCGCCCCTTCTTCTT	0.632000													24	58					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50764888	50764888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50764888C>T	ENST00000440075.2	+	21	2628	c.2581C>T	c.(2581-2583)Cgc>Tgc	p.R861C	MYH14_ENST00000425460.1_Missense_Mutation_p.R828C|MYH14_ENST00000376970.2_Missense_Mutation_p.R853C|MYH14_ENST00000598205.1_Missense_Mutation_p.R828C|MYH14_ENST00000596571.1_Missense_Mutation_p.R820C|MYH14_ENST00000262269.8_Missense_Mutation_p.R861C|MYH14_ENST00000601313.1_Missense_Mutation_p.R861C			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	820					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		ATACCTGGCTCGCAGGTGGGC	0.662000													13	13					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17228372	17228372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:17228372C>T	ENST00000261381.6	-	9	2069	c.1985G>A	c.(1984-1986)cGg>cAg	p.R662Q	CTD-2576D5.4_ENST00000567344.1_RNA	NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	662					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CGTCTCGGCCCGTCGAAGACC	0.612000													7	89					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141359	143141359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143141359C>T	ENST00000332690.1	+	1	814	c.814C>T	c.(814-816)Cca>Tca	p.P272S	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	272					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					AGGTATTTTTCCACCTCTGGA	0.488000													67	137					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118375399	118375399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118375399C>T	ENST00000534358.1	+	27	8815	c.8792C>T	c.(8791-8793)cCa>cTa	p.P2931L	KMT2A_ENST00000389506.5_Missense_Mutation_p.P2928L|KMT2A_ENST00000354520.4_Missense_Mutation_p.P2890L	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CTAGAGCTACCATCTGATCTG	0.498000													49	129					0	0	1	0	0
RFC3	5983	broad.mit.edu	37	13	34409298	34409298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:34409298C>T	ENST00000380071.3	+	8	953	c.823C>T	c.(823-825)Cgt>Tgt	p.R275C	RFC3_ENST00000434425.1_Missense_Mutation_p.R275C	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	275					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		CCTTGAAGTTCGTGGAAGGCT	0.313000													13	76					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451045	138451045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138451045G>A	ENST00000344876.4	-	1	2584	c.2198C>T	c.(2197-2199)tCc>tTc	p.S733F	PCDH18_ENST00000412923.2_Missense_Mutation_p.S733F|PCDH18_ENST00000507846.1_Missense_Mutation_p.S513F|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	733					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					GCAGTTATAGGATCTAGTGTC	0.438000													18	59					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140777335	140777335	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140777335G>A	ENST00000371372.1	+	3	675	c.530_splice	c.e3+1	p.G177_splice	CACNA1B_ENST00000277551.2_Splice_Site_p.G177_splice|RP11-188C12.3_ENST00000371390.1_RNA|CACNA1B_ENST00000371363.1_Splice_Site_p.G177_splice|CACNA1B_ENST00000371355.4_Splice_Site_p.G177_splice|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371357.1_Splice_Site_p.G177_splice	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	177					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GTCCTCACAGGGTAGGCAAGC	0.622000													37	221					0	0	1	0	0
DDX24	57062	broad.mit.edu	37	14	94527347	94527347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94527347G>A	ENST00000330836.5	-	4	1440	c.1309C>T	c.(1309-1311)Cgt>Tgt	p.R437C	DDX24_ENST00000555054.1_Missense_Mutation_p.R394C|DDX24_ENST00000544005.1_Missense_Mutation_p.R187C	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	437	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		ATCTCAGGACGACGGTTCAGC	0.443000													50	117					0	0	1	0	0
VRK3	51231	broad.mit.edu	37	19	50504104	50504104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50504104G>A	ENST00000443401.2	-	5	492	c.14C>T	c.(13-15)cCa>cTa	p.P5L	VRK3_ENST00000594092.1_Silent_p.P185P|VRK3_ENST00000599538.1_Silent_p.P185P|VRK3_ENST00000377011.2_Silent_p.P135P|VRK3_ENST00000316763.3_Silent_p.P185P|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000594948.1_Silent_p.P185P|VRK3_ENST00000601341.1_Silent_p.P135P|VRK3_ENST00000601912.1_Silent_p.P135P|VRK3_ENST00000593919.1_Silent_p.P185P			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	0						nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GGGTGGAGGTGGGTGCAGCTG	0.572000													6	26					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67129918	67129918	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67129918G>A	ENST00000284425.2	-	6	829	c.655C>T	c.(655-657)Cac>Tac	p.H219Y		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	219					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATCTCATTGTGAAGAAGATTT	0.313000													10	67					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97547984	97547984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:97547984C>T	ENST00000370192.3	-	22	2909	c.2809G>A	c.(2809-2811)Gaa>Aaa	p.E937K		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	937					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TTGCTCAATTCACCAAATGTT	0.363000													34	144					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6896430	6896430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6896430C>T	ENST00000312053.4	+	3	153	c.116C>T	c.(115-117)aCc>aTc	p.T39I	EMR1_ENST00000601198.1_3'UTR|EMR1_ENST00000450315.3_Missense_Mutation_p.T39I|EMR1_ENST00000381404.4_Missense_Mutation_p.T39I|EMR1_ENST00000250572.8_Missense_Mutation_p.T39I|EMR1_ENST00000381407.5_Missense_Mutation_p.T39I	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	39	EGF-like 1.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					AGAGACAGTACCTTGTGCCCA	0.453000													31	171					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19372292	19372292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19372292C>T	ENST00000291481.7	-	2	147	c.84G>A	c.(82-84)ggG>ggA	p.G28G	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	28					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			CACGCTGCGCCCCCGCAGGGG	0.726000													8	51					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49446098	49446098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49446098G>A	ENST00000374201.3	-	8	1159	c.857C>T	c.(856-858)tCg>tTg	p.S286L	FRMPD2_ENST00000407470.4_Missense_Mutation_p.S255L|FRMPD2_ENST00000305531.3_Missense_Mutation_p.S262L	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	286					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GTCTGCTGCCGAGTGCACAGA	0.572000													39	77					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22362829	22362829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22362829C>T	ENST00000397121.2	-	3	2007	c.1690G>A	c.(1690-1692)Gaa>Aaa	p.E564K		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CCACATTCTTCACATTTGTAG	0.378000													34	90					0	0	1	0	0
IL36G	56300	broad.mit.edu	37	2	113736846	113736846	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113736846G>A	ENST00000259205.4	+	3	173	c.104G>A	c.(103-105)tGg>tAg	p.W35*	IL36G_ENST00000376489.2_Intron	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	35					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						CAGCAAGTGTGGACCCTTCAG	0.448000													12	59					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907474	12907474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12907474C>T	ENST00000317869.6	-	2	894	c.669G>A	c.(667-669)gaG>gaA	p.E223E		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TACTGCTCTGCTCCTCTTCTG	0.463000													62	180					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57868278	57868278	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57868278C>T	ENST00000391705.3	+	4	1325	c.1041C>T	c.(1039-1041)agC>agT	p.S347S	ZNF304_ENST00000443917.2_Silent_p.S394S|ZNF304_ENST00000282286.5_Silent_p.S347S|ZNF304_ENST00000598744.1_Silent_p.S305S	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		ACAGCAGAAGCTCCCACCTTG	0.473000													31	78					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178139858	178139858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178139858G>A	ENST00000335815.2	-	5	1218	c.1021C>T	c.(1021-1023)Ctt>Ttt	p.L341F		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	341					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		CATCCAGAAAGGGATGTGCTG	0.403000													47	89					0	0	1	0	0
MPL	4352	broad.mit.edu	37	1	43803534	43803534	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43803534C>T	ENST00000372470.3	+	1	57	c.15C>T	c.(13-15)gcC>gcT	p.A5A	MPL_ENST00000413998.2_Silent_p.A5A	NM_005373.2	NP_005364.1	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	5					cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(551)|large_intestine(3)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	567	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTCCTGGGCCCTCTTCATGG	0.632000			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						7	18					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22047044	22047044	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:22047044A>T	ENST00000261200.4	-	12	1723	c.1724T>A	c.(1723-1725)cTg>cAg	p.L575Q	ABCC9_ENST00000261201.4_Missense_Mutation_p.L575Q|ABCC9_ENST00000345162.2_Missense_Mutation_p.L575Q	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	575	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAAGAGAGACAGTGAAGCAAA	0.478000													13	97					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985509	108985509	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108985509C>T	ENST00000392806.3	-	2	819	c.651G>A	c.(649-651)caG>caA	p.Q217Q		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	217						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						CCTGGACTTCCTGGTCCCCCT	0.697000													12	79					0	0	1	0	0
GTPBP3	84705	broad.mit.edu	37	19	17448979	17448979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17448979C>T	ENST00000324894.8	+	2	284	c.216C>T	c.(214-216)ccC>ccT	p.P72P	GTPBP3_ENST00000600625.1_Silent_p.P72P|GTPBP3_ENST00000358792.7_Silent_p.P72P|GTPBP3_ENST00000361619.5_Silent_p.P94P|GTPBP3_ENST00000598038.1_3'UTR	NM_032620.3|NM_133644.3	NP_116009.2|NP_598399.2	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial)	72					tRNA modification	mitochondrion	GTP binding|GTPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	18						GAGACCTGCCCCTTGCTCGCC	0.711000													4	16					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69718372	69718372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69718372G>A	ENST00000194900.4	+	16	2259	c.1918G>A	c.(1918-1920)Gga>Aga	p.G640R	DLG3_ENST00000374360.3_Missense_Mutation_p.G608R|DLG3_ENST00000542398.1_Missense_Mutation_p.G157R|DLG3_ENST00000374355.3_Missense_Mutation_p.G303R|DLG3_ENST00000461646.1_3'UTR			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	608	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					TGTTGCAGAAGGACAAGAGGA	0.517000													8	13					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255871	140255871	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140255871G>A	ENST00000398631.2	+	1	814	c.814G>A	c.(814-816)Gga>Aga	p.G272R	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAGACGAAGGACTTAATGG	0.383000													39	130					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143633133	143633133	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143633133C>T	ENST00000408955.2	+	1	875	c.808C>T	c.(808-810)Caa>Taa	p.Q270*		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CTCAGTCCTTCAAGAGAAGCT	0.507000													41	96					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122001064	122001064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122001064G>A	ENST00000498619.1	+	6	2181	c.1743G>A	c.(1741-1743)ggG>ggA	p.G581G	CASR_ENST00000296154.5_Silent_p.G571G|CASR_ENST00000490131.1_Silent_p.G571G	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	571					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GTCCTGATGGGGAGTATAGTG	0.597000													31	67					0	0	1	0	0
CAMK1G	57172	broad.mit.edu	37	1	209783237	209783237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209783237G>A	ENST00000009105.1	+	9	1035	c.790G>A	c.(790-792)Gag>Aag	p.E264K	CAMK1G_ENST00000361322.2_Missense_Mutation_p.E264K|CAMK1G_ENST00000494990.1_3'UTR			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	264	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		GGATCCGAACGAGCGGTACAC	0.498000													21	76					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29430158	29430158	+	Silent	SNP	C	C	T	rs144363872	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29430158C>T	ENST00000377136.1	+	4	1077	c.612C>T	c.(610-612)ttC>ttT	p.F204F	OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377133.1_Silent_p.F204F|OR2H1_ENST00000442615.1_Silent_p.F204F|OR2H1_ENST00000396792.2_Silent_p.F204F|OR2H1_ENST00000377132.1_Silent_p.F204F			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						GTGTCATCTTCGTGGTTGTGC	0.502000													67	168					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33628011	33628011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33628011C>T	ENST00000380099.3	+	2	935	c.927C>T	c.(925-927)acC>acT	p.T309T	KL_ENST00000426690.2_Silent_p.T2T|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	309	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GAAGAATGACCGACCACAGCA	0.463000													56	183					0	0	1	0	0
RP11-337C18.8	0	broad.mit.edu	37	1	146649854	146649854	+	RNA	SNP	C	C	T	rs1053423		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:146649854C>T	ENST00000607149.1	+	0	350																											AGTTCTTCGCCCCCTGGTGTG	0.567000													10	111					0	0	1	0	0
IFNA2	3440	broad.mit.edu	37	9	21384900	21384900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21384900C>T	ENST00000380206.2	-	1	496	c.429G>A	c.(427-429)agG>agA	p.R143R		NM_000605.3	NP_000596.2	P01563	IFNA2_HUMAN	interferon, alpha 2	143					blood coagulation|cell-cell signaling|induction of apoptosis|inflammatory response|negative regulation of interleukin-13 secretion|negative regulation of interleukin-5 secretion|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of transcription, DNA-dependent|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(2)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)	13				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)	Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	GGAAGTATTTCCTCACAGCCA	0.478000													103	213					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130060506	130060506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130060506C>T	ENST00000278742.5	+	7	1210	c.792C>T	c.(790-792)gaC>gaT	p.D264D		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	264	CUB 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GCAGCTTTGACCTTGCGTCCT	0.701000													9	21					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23895187	23895187	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23895187C>T	ENST00000355349.3	-	19	2310	c.2148G>A	c.(2146-2148)ggG>ggA	p.G716G		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	716	Myosin head-like.		G -> R (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCCGGAAGTCCCCGTAGAGGA	0.607000													14	51					0	0	1	0	0
CLEC4G	339390	broad.mit.edu	37	19	7794920	7794920	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7794920C>T	ENST00000328853.5	-	7	680	c.612G>A	c.(610-612)ggG>ggA	p.G204G		NM_001244856.1|NM_198492.3	NP_001231785.1|NP_940894.1	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	204	C-type lectin.					integral to membrane	protein binding|sugar binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(1)|lung(1)	6						CATCCAGGCCCCCAACGATCA	0.677000													6	10					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96267073	96267073	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96267073C>T	ENST00000225235.4	+	7	1679	c.1569C>T	c.(1567-1569)ttC>ttT	p.F523F		NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	523	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				GGAAAAGTTTCAGTGAAACAA	0.338000													16	85					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6919588	6919588	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6919588G>T	ENST00000312053.4	+	13	1487	c.1450G>T	c.(1450-1452)Gtg>Ttg	p.V484L	EMR1_ENST00000450315.3_Missense_Mutation_p.V307L|EMR1_ENST00000381404.4_Missense_Mutation_p.V432L|EMR1_ENST00000250572.8_Missense_Mutation_p.V484L|EMR1_ENST00000381407.5_Missense_Mutation_p.V343L	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	484	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TGTCTCCTTTGTGGGCATGGA	0.453000													55	101					7.41606e-26	7.46548e-26	1	1	0
AVEN	57099	broad.mit.edu	37	15	34160047	34160047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34160047G>A	ENST00000306730.3	-	5	751	c.622C>T	c.(622-624)Cct>Tct	p.P208S	AVEN_ENST00000558136.1_5'UTR	NM_020371.2	NP_065104.1	Q9NQS1	AVEN_HUMAN	apoptosis, caspase activation inhibitor	208					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|stomach(1)	7		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		ACCTCTAAAGGAACTGTACCC	0.448000													21	71					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56436015	56436015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56436015G>A	ENST00000584437.1	-	8	3077	c.1122C>T	c.(1120-1122)ccC>ccT	p.P374P	RNF43_ENST00000407977.2_Silent_p.P374P|RNF43_ENST00000500597.2_Silent_p.P333P|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000577716.1_Silent_p.P374P|RNF43_ENST00000583753.1_Silent_p.P333P|RNF43_ENST00000581868.1_Silent_p.P247P|RNF43_ENST00000577625.1_Silent_p.P247P			Q68DV7	RNF43_HUMAN	ring finger protein 43	374						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATGGCAGGAAGGGACCAGGTC	0.687000													4	3					0	0	1	0	0
KCNN1	3780	broad.mit.edu	37	19	18092675	18092675	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18092675C>T	ENST00000601725.1	+	0	291																											ACGTACGCGCCCTCGGTGGCC	0.652000													9	25					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241812439	241812439	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241812439G>A	ENST00000307503.3	+	5	955	c.568G>A	c.(568-570)Ggg>Agg	p.G190R		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	190			G -> R (in HP1).		glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity	p.G190R(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ATCCCTGGGCGGGACCCCCCT	0.662000													14	120					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42695102	42695102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:42695102C>T	ENST00000230882.4	+	5	540	c.350C>T	c.(349-351)tCg>tTg	p.S117L	GHR_ENST00000357703.3_Missense_Mutation_p.S95L|GHR_ENST00000537449.1_5'UTR	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	117					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTTAATTCATCGTTTACCTCC	0.378000													15	38					0	0	1	0	0
SLC5A5	6528	broad.mit.edu	37	19	17986820	17986820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17986820C>T	ENST00000222248.3	+	5	950	c.603C>T	c.(601-603)ggC>ggT	p.G201G		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	201					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						TGCTAAGTGGCTTCTGGGTTG	0.622000													18	76					0	0	1	0	0
MS4A6A	64231	broad.mit.edu	37	11	59949119	59949119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59949119C>T	ENST00000528851.1	-	2	222	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	MS4A6A_ENST00000323961.3_Missense_Mutation_p.E28K|MS4A6A_ENST00000530839.1_Missense_Mutation_p.E28K|MS4A6A_ENST00000420732.2_Missense_Mutation_p.E28K|MS4A6A_ENST00000533023.1_Missense_Mutation_p.E28K|MS4A6A_ENST00000532169.1_Missense_Mutation_p.E28K|MS4A6A_ENST00000529054.1_Missense_Mutation_p.E56K|MS4A6A_ENST00000412309.2_Missense_Mutation_p.E56K|MS4A6A_ENST00000426738.2_Missense_Mutation_p.E28K			Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member 6A	28						integral to membrane	receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGGTGGGTTCGGGTTTCTCT	0.463000													57	127					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038256	75038256	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75038256C>T	ENST00000326665.5	-	14	3356	c.3138G>A	c.(3136-3138)agG>agA	p.R1046R	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1046	Glu-rich.							p.R1046S(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AAATTTCTTTCCTATCATCTT	0.453000													56	224					0	0	1	0	0
IL7	3574	broad.mit.edu	37	8	79710412	79710412	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:79710412G>A	ENST00000263851.4	-	2	642	c.42C>T	c.(40-42)ccC>ccT	p.P14P	IL7_ENST00000520269.1_Silent_p.P14P|IL7_ENST00000379113.2_Silent_p.P14P	NM_000880.3|NM_001199886.1|NM_001199887.1	NP_000871.1|NP_001186815.1|NP_001186816.1	P13232	IL7_HUMAN	interleukin 7	14					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding			endometrium(2)|large_intestine(2)|lung(1)	5						CAAGGATCAGGGGAGGAAGTC	0.353000													13	51					0	0	1	0	0
FADS6	283985	broad.mit.edu	37	17	72878706	72878706	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72878706G>A	ENST00000310226.6	-	3	506	c.492C>T	c.(490-492)ttC>ttT	p.F164F		NM_178128.3	NP_835229.2	Q8N9I5	FADS6_HUMAN	fatty acid desaturase 6	170					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity			endometrium(3)|kidney(1)|lung(4)	8	all_lung(278;0.172)|Lung NSC(278;0.207)					AAGGAGCAAGGAACATGTAGA	0.612000													6	16					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122532572	122532572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:122532572G>A	ENST00000264357.5	+	7	1290	c.998G>A	c.(997-999)cGg>cAg	p.R333Q	GRIA3_ENST00000542149.1_Missense_Mutation_p.R333Q|GRIA3_ENST00000541091.1_Missense_Mutation_p.R317Q|GRIA3_ENST00000371256.5_Missense_Mutation_p.R333Q|GRIA3_ENST00000371251.1_Missense_Mutation_p.R333Q	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	333					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity	p.R333Q(3)		breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	GATGTGTCCCGGAGAGGAAGT	0.483000													19	11					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324066	152324066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152324066G>A	ENST00000388718.5	-	3	6268	c.6196C>T	c.(6196-6198)Cat>Tat	p.H2066Y	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2066							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTCTCATGAACTGAGGAT	0.532000													196	481					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45127468	45127468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45127468C>T	ENST00000296129.1	-	9	2307	c.2173G>A	c.(2173-2175)Ggg>Agg	p.G725R		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	725						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCCTTTCGCCCTTTCTGAAAC	0.488000													26	290					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53069372	53069372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53069372C>T	ENST00000252244.3	-	9	1598	c.1540G>A	c.(1540-1542)Gga>Aga	p.G514R		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	514	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						ctgccacctccacTGATGGTG	0.607000													17	42					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68934353	68934353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68934353G>A	ENST00000288368.4	+	4	696	c.419G>A	c.(418-420)aGa>aAa	p.R140K	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	140	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AACAAAATAAGAACAATCCGG	0.328000													5	52					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13363279	13363279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13363279G>A	ENST00000254508.5	-	36	5054	c.4972C>T	c.(4972-4974)Ctg>Ttg	p.L1658L		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1658					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TTCATGCTCAGGTGCTTCCGC	0.592000													41	298					0	0	1	0	0
H2AFY2	55506	broad.mit.edu	37	10	71853601	71853601	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71853601G>A	ENST00000373255.4	+	5	852	c.588_splice	c.e5+1	p.K196_splice		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	196	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						TGGGACAGAAGGTAACAAAGA	0.418000													11	33					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128498536	128498536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128498536G>A	ENST00000325888.8	+	48	8398	c.8137G>A	c.(8137-8139)Gaa>Aaa	p.E2713K	FLNC_ENST00000346177.6_Missense_Mutation_p.E2680K|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2713	Interaction with INPPL1.|Self-association site, tail (By similarity).				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GTGGGGTGACGAAAGTGTCCC	0.542000													20	33					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15789234	15789234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15789234C>T	ENST00000359621.4	+	4	259	c.234C>T	c.(232-234)tcC>tcT	p.S78S		NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	78	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						CCAGCTCCTCCAGGACCTACC	0.617000													39	100					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070255	9070255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9070255C>T	ENST00000397910.4	-	3	17394	c.17191G>A	c.(17191-17193)Gaa>Aaa	p.E5731K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5733	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATTGTGATTCATGTCCAGAA	0.488000													25	72					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87173491	87173491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87173491C>T	ENST00000265724.3	-	18	2582	c.2165G>A	c.(2164-2166)gGa>gAa	p.G722E	ABCB1_ENST00000543898.1_Missense_Mutation_p.G658E	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	722	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity	p.G722V(1)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTGCAGGCCTCCATTTATAAT	0.358000													29	55					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228562353	228562353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228562353G>A	ENST00000570156.2	+	108	25508	c.25434G>A	c.(25432-25434)ctG>ctA	p.L8478L	OBSCN_ENST00000366707.4_Silent_p.L5155L|OBSCN_ENST00000422127.1_Silent_p.L7521L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7521					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCCAGCTTCTGACCATCCTGG	0.622000													25	65					0	0	1	0	0
KCTD9	54793	broad.mit.edu	37	8	25298174	25298174	+	Missense_Mutation	SNP	G	G	A	rs143658803	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:25298174G>A	ENST00000221200.4	-	4	450	c.230C>T	c.(229-231)tCt>tTt	p.S77F	KCTD9_ENST00000518067.1_5'UTR	NM_017634.3	NP_060104.2	Q7L273	KCTD9_HUMAN	potassium channel tetramerization domain containing 9	77	KHA.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(2)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)	12		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)		AGGAGGCTTAGAATCTGTCTG	0.393000													28	53					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35700224	35700224	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35700224G>A	ENST00000314888.9	-	49	6977	c.6624C>T	c.(6622-6624)agC>agT	p.S2208S	TLN1_ENST00000540444.1_Silent_p.S2096S	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	2208					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TAGCACGGCGGCTCAGATTGG	0.537000													9	79					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247712462	247712462	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247712462C>T	ENST00000366490.3	+	4	489	c.331C>T	c.(331-333)Cag>Tag	p.Q111*	GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366491.2_5'UTR|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366489.1_5'UTR|GCSAML_ENST00000536561.1_5'UTR|GCSAML_ENST00000366488.4_5'UTR|GCSAML_ENST00000527541.1_Intron					germinal center-associated, signaling and motility-like																		GAGTGAAACTCAGGAGCTGAG	0.502000													6	60					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61564393	61564393	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61564393G>A	ENST00000457692.1	+	5	690	c.357G>A	c.(355-357)ggG>ggA	p.G119G	SERPINB2_ENST00000482254.1_3'UTR|SERPINB2_ENST00000299502.4_Silent_p.G119G	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	119					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CATCCACAGGGAATTATTTAC	0.408000													37	79					0	0	1	0	0
ZNF652	22834	broad.mit.edu	37	17	47390089	47390089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47390089G>A	ENST00000362063.2	-	3	1337	c.1019C>T	c.(1018-1020)aCc>aTc	p.T340I	ZNF652_ENST00000430262.2_Missense_Mutation_p.T340I	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			ATGAGCCATGGTATAGAATTT	0.378000													16	54					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15646221	15646221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15646221C>T	ENST00000378076.3	-	20	2457	c.2104G>A	c.(2104-2106)Gaa>Aaa	p.E702K	ITGA8_ENST00000477064.1_5'UTR	NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	702					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TTGTTGCGTTCGATTCCAACA	0.383000													36	77					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	80993272	80993272	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:80993272G>A	ENST00000555265.1	-	23	3388	c.3013C>T	c.(3013-3015)Cgc>Tgc	p.R1005C	CEP128_ENST00000553717.1_5'UTR|CEP128_ENST00000281129.3_Missense_Mutation_p.R1005C			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	1005						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						GAATTTCTGCGAACCCTGTAT	0.348000													18	76					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539571	56539571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56539571C>T	ENST00000390649.3	+	7	1972	c.1972C>T	c.(1972-1974)Ccc>Tcc	p.P658S		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	658						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTGTCCCGTTCCCCTGGGGGT	0.587000													31	79					0	0	1	0	0
ESRP2	80004	broad.mit.edu	37	16	68266310	68266310	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68266310C>T	ENST00000473183.2	-	8	1456	c.918G>A	c.(916-918)caG>caA	p.Q306Q	ESRP2_ENST00000565858.1_Silent_p.Q316Q			Q9H6T0	ESRP2_HUMAN	epithelial splicing regulatory protein 2	316	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			NS(1)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	16						GCTTGTGTCTCTGCAGCGCTA	0.637000													15	65					0	0	1	0	0
ERVFRD-1	405754	broad.mit.edu	37	6	11104936	11104936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:11104936C>T	ENST00000472091.1	-	2	983	c.608G>A	c.(607-609)cGa>cAa	p.R203Q	ERVFRD-1_ENST00000542862.1_Missense_Mutation_p.R203Q|SMIM13_ENST00000416247.2_Intron	NM_207582.2	NP_997465.1	P60508	EFRD1_HUMAN		203						integral to membrane|plasma membrane|virion		p.R203Q(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(4)|stomach(1)	15						CCAGAAGTTTCGAGTACTGCA	0.463000													55	126					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100532314	100532314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100532314G>A	ENST00000457717.1	+	14	2040	c.1784G>A	c.(1783-1785)cGa>cAa	p.R595Q	MTTP_ENST00000511045.1_Missense_Mutation_p.R622Q|RP11-766F14.1_ENST00000508578.1_RNA|MTTP_ENST00000265517.5_Missense_Mutation_p.R595Q	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	595	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	ATTGTCCGTCGAGTTCTGAAG	0.398000													12	85					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152470822	152470822	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152470822G>A	ENST00000427231.2	-	77	11771	c.11569C>T	c.(11569-11571)Cag>Tag	p.Q3857*	NEB_ENST00000409198.1_Nonsense_Mutation_p.Q3614*|NEB_ENST00000397345.3_Nonsense_Mutation_p.Q3857*|NEB_ENST00000604864.1_Nonsense_Mutation_p.Q3857*|NEB_ENST00000172853.10_Nonsense_Mutation_p.Q3614*|NEB_ENST00000603639.1_Nonsense_Mutation_p.Q3857*	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3857					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCCGAGCCTGAATGACGTCA	0.473000													43	96					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134125725	134125725	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134125725G>A	ENST00000220616.4	+	44	7672	c.7632G>A	c.(7630-7632)caG>caA	p.Q2544Q	TG_ENST00000377869.1_Silent_p.Q2487Q|TG_ENST00000519543.1_Silent_p.Q677Q|TG_ENST00000542445.1_Silent_p.Q914Q	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2544					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGCACTGCAGAATTCTCTGG	0.498000													24	75					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94112962	94112962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94112962C>T	ENST00000553484.1	+	37	6390	c.6236C>T	c.(6235-6237)tCc>tTc	p.S2079F	UNC79_ENST00000555664.1_Missense_Mutation_p.S2018F|UNC79_ENST00000393151.2_Missense_Mutation_p.S2057F|UNC79_ENST00000256339.4_Missense_Mutation_p.S1880F			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2057						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AGATTGGCATCCAGTACTACC	0.393000													19	44					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9017436	9017436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9017436C>T	ENST00000397910.4	-	26	38091	c.37888G>A	c.(37888-37890)Gag>Aag	p.E12630K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12632	SEA 4.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATAGCTGCTCCCTGTCCACT	0.582000													17	180					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367196	107367196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107367196G>A	ENST00000542196.1	-	1	755	c.713C>T	c.(712-714)tCc>tTc	p.S238F		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	238					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ACAGGTAGAGGAAGCTTTGCT	0.398000													6	85					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893798	36893798	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36893798G>A	ENST00000301807.6	-	13	4703	c.2806C>T	c.(2806-2808)Cag>Tag	p.Q936*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.Q1486*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.Q936*	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1486					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAATAGAACTGAAGTAAATCC	0.418000													4	17					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75968884	75968884	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75968884C>T	ENST00000308508.5	-	10	6068	c.5976G>A	c.(5974-5976)gtG>gtA	p.V1992V	CTD-2026K11.1_ENST00000569467.1_RNA	NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1992	Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GCCGCCCGCCCACCAGGAGAT	0.617000													16	113					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34100921	34100921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34100921C>T	ENST00000373381.4	-	31	5155	c.4979G>A	c.(4978-4980)gGg>gAg	p.G1660E	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.G533E	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1620	CUB 10.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ATACTGTCCCCCACAGGGGGC	0.552000											OREG0013349	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	32					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105258925	105258925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:105258925G>A	ENST00000306107.5	+	7	1337	c.837G>A	c.(835-837)gaG>gaA	p.E279E	ALCAM_ENST00000389927.4_Intron|ALCAM_ENST00000486979.2_Silent_p.E228E|ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000472644.2_Silent_p.E279E	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	279	Ig-like C2-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						CTCCCCCAGAGGAATTTTTGT	0.393000													20	188					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171080016	171080016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171080016C>T	ENST00000367755.4	+	6	816	c.705C>T	c.(703-705)ctC>ctT	p.L235L	FMO3_ENST00000538429.1_Silent_p.L172L|FMO3_ENST00000542847.1_Silent_p.L215L|FMO3_ENST00000392085.2_Silent_p.L235L	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	235					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACATGCTGCTCGTCACTCGAT	0.463000													67	159					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52269605	52269605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:52269605G>A	ENST00000354831.7	-	22	2587	c.2398C>T	c.(2398-2400)Ctt>Ttt	p.L800F	NRD1_ENST00000539524.1_Missense_Mutation_p.L668F|NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000544028.1_Missense_Mutation_p.L600F|NRD1_ENST00000352171.7_Missense_Mutation_p.L732F	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	731					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TTATGCGTAAGGATATTGACA	0.383000													5	47					0	0	1	0	0
SUCLG2	8801	broad.mit.edu	37	3	67570915	67570915	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:67570915G>A	ENST00000307227.5	-	5	588	c.561C>T	c.(559-561)ctC>ctT	p.L187L	SUCLG2_ENST00000493112.1_Silent_p.L187L|SUCLG2_ENST00000492795.1_Silent_p.L187L	NM_003848.3	NP_003839.2	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming, beta subunit	187	ATP-grasp.				succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	10		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	CCTTAAAAATGAGCTCCGGGT	0.498000													44	94					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76348532	76348532	+	Splice_Site	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76348532T>A	ENST00000312916.7	+	9	1749	c.1365_splice	c.e9-1	p.F456_splice		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	456	FHA.				angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		CTTTCTAAGTTTCATGCAGAA	0.299000													7	49					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96970536	96970536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96970536C>T	ENST00000341686.3	+	5	866	c.741C>T	c.(739-741)ttC>ttT	p.F247F	C10orf129_ENST00000430183.1_Silent_p.F92F|C10orf129_ENST00000394005.3_Silent_p.F247F	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	247					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GAATGGGATTCAGCCAGGCTT	0.493000													21	59					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248004718	248004718	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248004718G>A	ENST00000355784.2	-	1	536	c.481C>T	c.(481-483)Ctg>Ttg	p.L161L		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAAATCATCAGGGAAGGCAGA	0.557000													31	90					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77691833	77691833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77691833G>A	ENST00000296043.6	+	10	6357	c.5404G>A	c.(5404-5406)Ggg>Agg	p.G1802R	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1802	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GGAGGCGAAGGGGAGCCTGCT	0.552000													26	82					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20555588	20555588	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20555588C>T	ENST00000504154.1	+	26	2974	c.2722C>T	c.(2722-2724)Caa>Taa	p.Q908*	SLIT2_ENST00000273739.5_Nonsense_Mutation_p.Q912*|SLIT2_ENST00000503823.1_Nonsense_Mutation_p.Q900*|SLIT2_ENST00000503837.1_Nonsense_Mutation_p.Q904*	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	908	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ATTTACCTGTCAAGGTATGGT	0.338000													30	71					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197298091	197298091	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197298091G>A	ENST00000367400.3	+	2	745	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	CRB1_ENST00000535699.1_Missense_Mutation_p.E135K|CRB1_ENST00000538660.1_Missense_Mutation_p.E204K|CRB1_ENST00000367399.2_Missense_Mutation_p.E204K	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	204	EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATGCCTCAATGAAATAGGAAG	0.443000													15	38					0	0	1	0	0
KLK5	25818	broad.mit.edu	37	19	51446957	51446957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51446957C>T	ENST00000336334.3	-	6	1164	c.812G>A	c.(811-813)aGa>aAa	p.R271K	KLK5_ENST00000391809.2_Missense_Mutation_p.R271K|KLK5_ENST00000593428.1_Missense_Mutation_p.R271K	NM_012427.4	NP_036559.1	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5	271	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			NS(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		GACACCCGGTCTGTTGGGCCG	0.597000													20	86					0	0	1	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55045040	55045040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55045040C>T	ENST00000335056.3	+	3	198	c.160C>T	c.(160-162)Cgg>Tgg	p.R54W															p.R54W(1)		endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		TTCCCATCTTCGGTTTGTCAT	0.537000													13	29					0	0	1	0	0
ADAMTSL5	339366	broad.mit.edu	37	19	1510897	1510897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1510897G>A	ENST00000330475.4	-	2	489	c.46C>T	c.(46-48)Ctc>Ttc	p.L16F	ADAMTSL5_ENST00000590562.1_5'UTR|ADAMTSL5_ENST00000413997.2_Missense_Mutation_p.L26F|ADAMTSL5_ENST00000395467.2_5'UTR	NM_213604.2	NP_998769.2	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5	16						proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGAGCAGGAGGTTCTGGAAG	0.652000													5	13					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168812899	168812899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168812899C>T	ENST00000464456.1	-	11	3593	c.2393G>A	c.(2392-2394)aGa>aAa	p.R798K	MECOM_ENST00000433243.2_Missense_Mutation_p.R808K|MECOM_ENST00000460814.1_Missense_Mutation_p.R798K|MECOM_ENST00000392736.3_Missense_Mutation_p.R807K|MECOM_ENST00000472280.1_Missense_Mutation_p.R808K|MECOM_ENST00000264674.3_Missense_Mutation_p.R872K|MECOM_ENST00000468789.1_Missense_Mutation_p.R807K|MECOM_ENST00000494292.1_Missense_Mutation_p.R986K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						CTTTAGGTGTCTGTCTAAATT	0.343000													13	44					0	0	1	0	0
FAM13B	51306	broad.mit.edu	37	5	137284808	137284808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137284808G>A	ENST00000033079.3	-	17	2381	c.1930C>T	c.(1930-1932)Cca>Tca	p.P644S	FAM13B_ENST00000425075.2_Missense_Mutation_p.P548S|FAM13B_ENST00000420893.2_Missense_Mutation_p.P644S	NM_016603.2	NP_057687.2	Q9NYF5	FA13B_HUMAN	family with sequence similarity 13, member B	644					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(4)|kidney(2)|lung(5)	11						AAGCTTTTTGGAAGTGTGTTA	0.383000													54	119					0	0	1	0	0
TMEM163	81615	broad.mit.edu	37	2	135260556	135260556	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:135260556G>A	ENST00000281924.6	-	5	535	c.471C>T	c.(469-471)atC>atT	p.I157I		NM_030923.4	NP_112185.1	Q8TC26	TM163_HUMAN	transmembrane protein 163	157						integral to membrane				endometrium(1)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(221;0.154)		TCACCCCCAAGATGACACAGG	0.443000													12	18					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72146759	72146759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72146759G>A	ENST00000356056.5	-	35	6777	c.6305C>T	c.(6304-6306)tCg>tTg	p.S2102L	MYO9A_ENST00000424560.1_Missense_Mutation_p.S2173L|MYO9A_ENST00000564571.1_Missense_Mutation_p.S2102L|MYO9A_ENST00000444904.1_Missense_Mutation_p.S2083L	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	2102	Rho-GAP.|Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTTATTAGTCGAACCAGACTT	0.363000													83	259					0	0	1	0	0
KCNN4	3783	broad.mit.edu	37	19	44278616	44278616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44278616G>A	ENST00000262888.3	-	3	806	c.411C>T	c.(409-411)tcC>tcT	p.S137S		NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	137					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	AGGGCTGCGGGGAGGTCAGCG	0.731000											OREG0025535	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	10					0	0	1	0	0
CDK2AP1	8099	broad.mit.edu	37	12	123751787	123751787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123751787G>A	ENST00000542174.1	-	1	837	c.14C>T	c.(13-15)tCa>tTa	p.S5L	CDK2AP1_ENST00000261692.2_Missense_Mutation_p.S33L|CDK2AP1_ENST00000544658.1_Missense_Mutation_p.S5L|CDK2AP1_ENST00000535979.1_Missense_Mutation_p.S5L|CDK2AP1_ENST00000538446.1_Missense_Mutation_p.S5L			O14519	CDKA1_HUMAN	cyclin-dependent kinase 2 associated protein 1	33					DNA-dependent DNA replication|protein phosphorylation|S phase of mitotic cell cycle	cytoplasm|nucleus	DNA binding|protein binding			lung(2)|stomach(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000554)|Epithelial(86;0.00178)		GCGGTACTGTGAAGACGTTGC	0.622000													23	78					0	0	1	0	0
ZNF251	90987	broad.mit.edu	37	8	145947971	145947971	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145947971G>A	ENST00000292562.7	-	5	1349	c.1074C>T	c.(1072-1074)ttC>ttT	p.F358F	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		AGCTTCGACTGAAGGCCTTCC	0.507000													22	72					0	0	1	0	0
SEH1L	81929	broad.mit.edu	37	18	12982560	12982560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:12982560C>T	ENST00000262124.11	+	7	932	c.805C>T	c.(805-807)Cat>Tat	p.H269Y	SEH1L_ENST00000592582.1_3'UTR|SEH1L_ENST00000399892.2_Missense_Mutation_p.H269Y	NM_031216.3	NP_112493.2	Q96EE3	SEH1_HUMAN	SEH1-like (S. cerevisiae)	269					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	11						GTTTGAAATCCATATAGTGGC	0.383000													11	114					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30091926	30091926	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30091926G>A	ENST00000567636.1	+	0	301					NR_003558.1																						AACAGCTCATGATGGTTTGAG	0.448000													20	55					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584153	82584153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82584153C>T	ENST00000423517.2	-	5	6453	c.6116G>A	c.(6115-6117)aGc>aAc	p.S2039N	PCLO_ENST00000333891.8_Missense_Mutation_p.S2039N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1970					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TATCTCATGGCTTTCTGGGAT	0.388000													5	61					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92543146	92543146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92543146C>T	ENST00000298047.6	+	12	9402	c.9385C>T	c.(9385-9387)Cct>Tct	p.P3129S	FAT3_ENST00000409404.2_Missense_Mutation_p.P3129S|FAT3_ENST00000525166.1_Missense_Mutation_p.P2979S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3129	Cadherin 28.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGATAACCCCCCTGTGTTTTC	0.542000										TCGA Ovarian(4;0.039)			24	57					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117788609	117788609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117788609C>T	ENST00000276204.6	+	43	4814	c.4740C>T	c.(4738-4740)atC>atT	p.I1580I	DOCK11_ENST00000276202.7_Silent_p.I1580I			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1580	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CCAAGAGAATCCGCACTGTTC	0.418000													40	19					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111965556	111965556	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111965556G>A	ENST00000369732.3	-	6	656	c.601C>T	c.(601-603)Cta>Tta	p.L201L	OVGP1_ENST00000540696.1_Silent_p.L141L|OVGP1_ENST00000481495.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	201					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CACCTTCCTAGAAAGCGCACA	0.557000													112	248					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227895176	227895176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227895176C>T	ENST00000396625.3	-	41	4163	c.3956G>A	c.(3955-3957)gGa>gAa	p.G1319E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1319E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1319	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GCCATCTTTTCCATCACATCC	0.522000													35	118					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124413966	124413966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124413966G>A	ENST00000409039.3	+	70	12122	c.12097G>A	c.(12097-12099)Gag>Aag	p.E4033K	CCDC92_ENST00000544798.1_Intron|DNAH10OS_ENST00000514254.2_3'UTR	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4033	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGTGGTGCAGGAGAGAAGGAA	0.517000													7	27					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609301	84609301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84609301G>A	ENST00000344803.2	+	4	3963	c.3916G>A	c.(3916-3918)Gga>Aga	p.G1306R		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AGAGCTTGATGGAGGGGATGC	0.532000													6	27					0	0	1	0	0
ZFP36L2	678	broad.mit.edu	37	2	43452023	43452023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43452023G>A	ENST00000282388.3	-	2	1213	c.920C>T	c.(919-921)tCc>tTc	p.S307F	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	307					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GGAGGCCgaggaacaggagga	0.781000													5	6					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30602580	30602580	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30602580G>A	ENST00000358107.4	-	10	2096	c.2097C>T	c.(2095-2097)ttC>ttT	p.F699F	MTPAP_ENST00000263063.3_Silent_p.F569F|MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	569					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						TGGTTTTTGTGAAATTTTCTG	0.363000													55	132					0	0	1	0	0
DGKZ	8525	broad.mit.edu	37	11	46398761	46398761	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:46398761C>T	ENST00000454345.1	+	26	3030	c.2906_splice	c.e26+1	p.R969_splice	DGKZ_ENST00000543978.1_Splice_Site_p.R133_splice|DGKZ_ENST00000318201.8_Splice_Site_p.R758_splice|DGKZ_ENST00000343674.6_Splice_Site_p.R797_splice|DGKZ_ENST00000527911.1_Splice_Site_p.R781_splice|DGKZ_ENST00000532868.2_Splice_Site_p.R785_splice|DGKZ_ENST00000395574.3_Splice_Site_p.R747_splice|DGKZ_ENST00000456247.2_Splice_Site_p.R780_splice|DGKZ_ENST00000421244.2_Splice_Site_p.R781_splice|DGKZ_ENST00000528615.1_Splice_Site_p.R559_splice	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	969					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		ACCCACGCCCCGGTGAGTCCT	0.637000													14	15					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72190375	72190375	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:72190375C>T	ENST00000555818.1	+	16	4631	c.4283C>T	c.(4282-4284)tCc>tTc	p.S1428F	SIPA1L1_ENST00000381232.3_Missense_Mutation_p.S1407F|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.S882F|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.S1407F|SIPA1L1_ENST00000554874.1_3'UTR	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1428	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACCATGAGCTCCCGACACTCT	0.547000													27	78					0	0	1	0	0
EVX1	2128	broad.mit.edu	37	7	27284711	27284711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27284711G>A	ENST00000496902.4	+	2	958	c.472G>A	c.(472-474)Gag>Aag	p.E158K	EVX1_ENST00000222761.3_Silent_p.A139A|EVX1_ENST00000535619.1_5'UTR|EVX1-AS_ENST00000517726.1_RNA			P49640	EVX1_HUMAN	even-skipped homeobox 1	158						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|liver(1)|lung(10)|prostate(1)|skin(1)	14						CGGAGGGAGCGAGACCCCCAA	0.667000													31	54					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98866842	98866842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98866842G>A	ENST00000477737.1	+	20	2939	c.2735G>A	c.(2734-2736)gGa>gAa	p.G912E	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	912										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AACCCCCAAGGAGCCAAACTC	0.408000													30	86					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063965	9063965	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9063965G>A	ENST00000397910.4	-	3	23684	c.23481C>T	c.(23479-23481)tcC>tcT	p.S7827S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7829	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGTCAGGGAGGAAGCTAGCT	0.542000													24	59					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67431935	67431935	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67431935C>T	ENST00000349015.3	-	8	1243	c.805G>A	c.(805-807)Gag>Aag	p.E269K	ALDH3B2_ENST00000530069.1_Missense_Mutation_p.E269K	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	269					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	TTGATGGCCTCGTCCACGCTC	0.652000													46	89					0	0	1	0	0
OR4C12	283093	broad.mit.edu	37	11	50003147	50003147	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:50003147C>T	ENST00000335238.4	-	1	924	c.891G>A	c.(889-891)agG>agA	p.R297R		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						TCCAAAGCTTCCTTATTGCAC	0.353000													10	33					0	0	1	0	0
SYT9	143425	broad.mit.edu	37	11	7334709	7334709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7334709G>A	ENST00000318881.6	+	3	818	c.581G>A	c.(580-582)gGa>gAa	p.G194E	SYT9_ENST00000396716.2_Missense_Mutation_p.G162E	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	194						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CAGTTGACTGGAATTGGTAGA	0.413000													9	93					0	0	1	0	0
ZNF491	126069	broad.mit.edu	37	19	11917576	11917576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11917576C>T	ENST00000323169.5	+	3	1139	c.808C>T	c.(808-810)Cct>Tct	p.P270S	ZNF491_ENST00000492230.1_Intron	NM_152356.3	NP_689569.2	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(14)|lung(6)|ovary(2)|skin(1)	26						TGGAGAGAGGCCTCATAAATG	0.408000													23	75					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168289904	168289904	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:168289904C>T	ENST00000366806.2	+	7	1049	c.907C>T	c.(907-909)Cct>Tct	p.P303S	MLLT4_ENST00000447894.2_Missense_Mutation_p.P303S|MLLT4_ENST00000351017.4_Missense_Mutation_p.P303S|MLLT4_ENST00000392108.3_Missense_Mutation_p.P303S|MLLT4_ENST00000392112.1_Missense_Mutation_p.P302S|MLLT4_ENST00000400822.3_Missense_Mutation_p.P302S|MLLT4_ENST00000344191.4_Missense_Mutation_p.P303S			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	303	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GGTTATGCTTCCTCCTGGAGC	0.333000			T	MLL	AL								44	55					0	0	1	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182869233	182869233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:182869233C>T	ENST00000367547.3	-	10	2083	c.1847G>A	c.(1846-1848)gGa>gAa	p.G616E	SHCBP1L_ENST00000423786.1_Missense_Mutation_p.G497E|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	688										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						TTTTTTATCTCCTGAAGAAGC	0.343000													15	21					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164393656	164393656	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164393656G>A	ENST00000280605.3	-	1	1391	c.1231C>T	c.(1231-1233)Caa>Taa	p.Q411*		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	411						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ATATTGGCTTGAGAAATGGCT	0.498000													18	32					0	0	1	0	0
TARS2	80222	broad.mit.edu	37	1	150471471	150471471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150471471C>T	ENST00000369064.3	+	12	1534	c.1500C>T	c.(1498-1500)ggC>ggT	p.G500G	TARS2_ENST00000606933.1_Silent_p.G418G|TARS2_ENST00000463555.1_3'UTR|TARS2_ENST00000369054.2_Silent_p.G370G|TARS2_ENST00000438568.2_3'UTR	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	500					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	GGCCATCTGGCTTCCTGGGGG	0.562000													10	125					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39895225	39895225	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39895225G>A	ENST00000373186.4	-	1	230	c.93C>T	c.(91-93)ggC>ggT	p.G31G	MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000340692.5_Intron|MOCS1_ENST00000425303.2_Silent_p.G31G|MOCS1_ENST00000432280.2_Intron|MOCS1_ENST00000373188.2_Intron|MOCS1_ENST00000308559.7_Intron|MOCS1_ENST00000373175.4_Intron	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	29	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGAAGCATGGGCCCCTGCTAC	0.637000													9	11					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130343086	130343086	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130343086C>T	ENST00000299164.2	+	8	2223	c.2223C>T	c.(2221-2223)ttC>ttT	p.F741F		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	741	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		ACGGGCATTTCGTGGTGTCGG	0.637000													31	56					0	0	1	0	0
CHST3	9469	broad.mit.edu	37	10	73768064	73768064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73768064C>T	ENST00000373115.4	+	3	1712	c.1275C>T	c.(1273-1275)ttC>ttT	p.F425F		NM_004273.4	NP_004264.2	Q7LGC8	CHST3_HUMAN	carbohydrate (chondroitin 6) sulfotransferase 3	425					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity			endometrium(1)|lung(5)	6						CGGAGCAGTTCGAGAAGTGGC	0.652000													5	5					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25261739	25261739	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25261739C>T	ENST00000395990.2	-	17	2031	c.1774G>A	c.(1774-1776)Gaa>Aaa	p.E592K	CASC1_ENST00000545133.1_Missense_Mutation_p.E573K|CASC1_ENST00000537577.1_Intron|CASC1_ENST00000395987.3_Missense_Mutation_p.E638K|CASC1_ENST00000354189.5_Intron|CASC1_ENST00000320267.9_Missense_Mutation_p.E632K	NM_001204102.1	NP_001191031.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	632										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			GTACATGCTTCAGTAAGGTGT	0.363000													8	21					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52159647	52159647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52159647G>A	ENST00000354534.5	+	16	2915	c.2737G>A	c.(2737-2739)Gaa>Aaa	p.E913K	SCN8A_ENST00000545061.1_Missense_Mutation_p.E913K|SCN8A_ENST00000550891.1_Missense_Mutation_p.E913K	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	913					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CCAGGACTGTGAACTCCCTCG	0.488000													66	115					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38227465	38227465	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38227465C>T	ENST00000373048.4	-	3	461	c.462G>A	c.(460-462)acG>acA	p.T154T	EPHA10_ENST00000427468.2_Silent_p.T154T|EPHA10_ENST00000319637.6_Silent_p.T154T	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	154						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCGCCGCGATCGTGTCGATTT	0.662000													23	31					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819601	159819601	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159819601G>A	ENST00000497452.1	-	0	517																											GAATCTGGAGGAAAACTGACC	0.423000													94	214					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45322706	45322706	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45322706A>G	ENST00000391955.1	+	12	1621	c.1577A>G	c.(1576-1578)aAc>aGc	p.N526S	BCAM_ENST00000270233.6_Missense_Mutation_p.N526S			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	526	Ig-like C2-type 3.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GAAGCCTCCAACCCCCACGGG	0.647000													28	71					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103427792	103427792	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103427792C>T	ENST00000358392.2	-	40	3407	c.3090G>A	c.(3088-3090)ggG>ggA	p.G1030G	COL11A1_ENST00000370096.3_Silent_p.G1018G|COL11A1_ENST00000512756.1_Silent_p.G902G|COL11A1_ENST00000353414.4_Silent_p.G979G	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1018	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTCCATCTTTCCCTGAGATAC	0.383000													41	77					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123519851	123519851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:123519851G>A	ENST00000422452.2	-	29	5815	c.5752C>T	c.(5752-5754)Ctg>Ttg	p.L1918L	TENM1_ENST00000371130.3_Silent_p.L1911L|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		ACTGAGAGCAGACAATCTGGT	0.498000													24	18					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44680451	44680451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44680451C>T	ENST00000590089.1	+	7	1403	c.1036C>T	c.(1036-1038)Cgt>Tgt	p.R346C	ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000337433.5_Missense_Mutation_p.R346C|ZNF226_ENST00000454662.2_Missense_Mutation_p.R346C			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				AGGTTTCAGTCGTAGATCAGC	0.463000													37	93					0	0	1	0	0
TMEM207	131920	broad.mit.edu	37	3	190158179	190158179	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:190158179C>T	ENST00000354905.2	-	4	225		c.e4-1			NM_207316.1	NP_997199.1	Q6UWW9	TM207_HUMAN	transmembrane protein 207							integral to membrane				endometrium(1)|large_intestine(2)|lung(4)	7	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)		CAGGAGGATCCTGACTCCAAA	0.517000													7	25					0	0	1	0	0
KIF3C	3797	broad.mit.edu	37	2	26203890	26203890	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26203890G>A	ENST00000264712.3	-	1	1476	c.897C>T	c.(895-897)gcC>gcT	p.A299A	KIF3C_ENST00000405914.1_Silent_p.A299A	NM_002254.6	NP_002245.4	O14782	KIF3C_HUMAN	kinesin family member 3C	299	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTTGCCCAGGGCAGATAATG	0.637000													10	42					0	0	1	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16852153	16852153	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:16852153G>A	ENST00000437538.2	-	2	214	c.206C>T	c.(205-207)cCa>cTa	p.P69L	TNFRSF13B_ENST00000579315.1_Missense_Mutation_p.P115L|TNFRSF13B_ENST00000581616.2_5'UTR|TNFRSF13B_ENST00000583789.1_Missense_Mutation_p.P69L|TNFRSF13B_ENST00000261652.2_Missense_Mutation_p.P115L			O14836	TR13B_HUMAN	tumor necrosis factor receptor superfamily, member 13B	115					cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|skin(1)	16						GAGCTCTGGTGGAAGGTTCAC	0.527000									IgA Deficiency, Selective				71	84					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108129689	108129689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108129689C>T	ENST00000273353.3	-	32	4352	c.4296G>A	c.(4294-4296)caG>caA	p.Q1432Q		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1432						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CCAGCTGCAGCTGGTGCCTGG	0.622000													17	41					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210411339	210411339	+	Missense_Mutation	SNP	G	G	A	rs146773666		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210411339G>A	ENST00000367012.3	+	2	264	c.34G>A	c.(34-36)Gag>Aag	p.E12K	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	12							protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TAGATTCTGCGAGCCCATTGT	0.483000													38	102					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63529377	63529377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:63529377G>A	ENST00000550760.3	+	2	291	c.112G>A	c.(112-114)Gga>Aga	p.G38R	RP11-3N2.13_ENST00000445978.1_RNA	NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	38	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						AGAGAACTACGGAAACCTGTT	0.388000													25	18					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212752	62212752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:62212752G>A	ENST00000519846.1	+	3	838	c.366G>A	c.(364-366)ctG>ctA	p.L122L	CLVS1_ENST00000518592.1_Intron|CLVS1_ENST00000325897.4_Silent_p.L122L|RP11-787D18.1_ENST00000518064.1_RNA			Q8IUQ0	CLVS1_HUMAN	clavesin 1	122	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						AGAGGGCTCTGATCGATGGGT	0.488000													15	52					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72399970	72399970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:72399970C>T	ENST00000340595.3	+	15	2371	c.2175C>T	c.(2173-2175)ttC>ttT	p.F725F	SLC4A4_ENST00000264485.5_Silent_p.F769F|SLC4A4_ENST00000425175.1_Silent_p.F769F|SLC4A4_ENST00000351898.6_Silent_p.F769F	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	769						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity	p.F725F(2)|p.F769F(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GAGGTTGGTTCGTTCCACCGT	0.423000													19	47					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75969356	75969356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75969356C>T	ENST00000274364.6	+	25	3448	c.3151C>T	c.(3151-3153)Ctg>Ttg	p.L1051L	IQGAP2_ENST00000396234.3_Silent_p.L547L|IQGAP2_ENST00000502745.1_Silent_p.L547L|IQGAP2_ENST00000379730.3_Silent_p.L553L	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1051	Ras-GAP.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CATTGAGAACCTGAGAAGGGT	0.418000													10	117					0	0	1	0	0
USP17L2	377630	broad.mit.edu	37	8	11994845	11994845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:11994845C>T	ENST00000333796.3	-	1	1741	c.1425G>A	c.(1423-1425)atG>atA	p.M475I	FAM66D_ENST00000434078.2_RNA	NM_001256869.1|NM_001256871.1|NM_001256872.1|NM_001256873.1|NM_001256874.1|NM_201402.2	NP_001243798.1|NP_001243800.1|NP_001243801.1|NP_001243802.1|NP_001243803.1|NP_958804.2	Q6R6M4	U17L2_HUMAN	ubiquitin specific peptidase 17-like family member 2	475					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(1)|kidney(1)|large_intestine(11)|liver(1)|lung(8)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	29						GATGGTTTTTCATCCCACACT	0.493000													24	15					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563735	176563735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176563735G>A	ENST00000367662.3	+	3	2159	c.995G>A	c.(994-996)gGa>gAa	p.G332E	PAPPA2_ENST00000367661.3_Missense_Mutation_p.G332E	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	332					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AAGGACAAGGGAAAGCGGGAT	0.562000													15	62					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41739911	41739911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:41739911G>A	ENST00000242208.4	-	2	308	c.62C>T	c.(61-63)tCc>tTc	p.S21F	INHBA-AS1_ENST00000422822.1_RNA|INHBA-AS1_ENST00000420821.1_RNA|AC005027.3_ENST00000416150.1_RNA|INHBA-AS1_ENST00000415848.2_RNA|INHBA_ENST00000442711.1_Missense_Mutation_p.S21F	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	21					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						TGGGGTGGGGGAACTCCTCAC	0.567000										TSP Lung(11;0.080)			87	180					0	0	1	0	0
INTS10	55174	broad.mit.edu	37	8	19703292	19703292	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:19703292C>T	ENST00000397977.3	+	16	2358	c.1960C>T	c.(1960-1962)Caa>Taa	p.Q654*		NM_018142.2	NP_060612.2	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	654					snRNA processing	integrator complex	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	20				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		ACTACCCAATCAAGGAATGCT	0.398000													15	52					0	0	1	0	0
MS4A6E	245802	broad.mit.edu	37	11	60105379	60105379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60105379C>T	ENST00000300182.4	+	2	378	c.313C>T	c.(313-315)Cct>Tct	p.P105S		NM_139249.2	NP_640342.1	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member 6E	105						integral to membrane	receptor activity			endometrium(2)|kidney(1)|lung(9)|stomach(1)	13						TTATCATTCACCTTACACCAT	0.408000													30	92					0	0	1	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935344	151935344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151935344G>A	ENST00000393902.3	-	3	1390	c.823C>T	c.(823-825)Cca>Tca	p.P275S	MAGEA3_ENST00000370278.3_Missense_Mutation_p.P275S			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	275	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGCCCTTGGACCCCACAGG	0.532000													73	52					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34030707	34030707	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34030707G>A	ENST00000389232.4	+	50	7642	c.7572G>A	c.(7570-7572)tgG>tgA	p.W2524*	RYR3_ENST00000415757.3_Nonsense_Mutation_p.W2524*	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2524	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTTCAGGATGGGGGAGCTACG	0.512000											OREG0023032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	47					0	0	1	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086747	46086747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46086747G>A	ENST00000360770.3	-	1	97	c.57C>T	c.(55-57)ccC>ccT	p.P19P	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	19	23 X 5 AA approximate repeats.					keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						CTGGCTGGCAGGGGCTGGGCG	0.657000													8	25					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39435943	39435943	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39435943G>A	ENST00000257408.4	+	2	1036	c.939G>A	c.(937-939)acG>acA	p.T313T		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	313	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						CGGAAAACACGATGGATATAT	0.468000													24	65					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8871662	8871662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:8871662G>A	ENST00000256707.3	-	30	4685	c.4504C>T	c.(4504-4506)Ctc>Ttc	p.L1502F	KIDINS220_ENST00000418530.1_Missense_Mutation_p.L1403F|KIDINS220_ENST00000473731.1_Missense_Mutation_p.L1483F|KIDINS220_ENST00000427284.1_Missense_Mutation_p.L1483F	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1502					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTCTGGAAGAGGCTTGACCTT	0.473000													19	46					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189706760	189706760	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189706760G>A	ENST00000319332.5	-	4	1088	c.891C>T	c.(889-891)cgC>cgT	p.R297R	LEPREL1_ENST00000427335.2_Silent_p.R116R	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	297					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGGGAGAGAGGCGGCCAGGGC	0.507000													18	96					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80750645	80750645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80750645C>T	ENST00000458043.2	+	48	5949	c.5943C>T	c.(5941-5943)ttC>ttT	p.F1981F	OTOGL_ENST00000547103.1_Silent_p.F1969F|OTOGL_ENST00000546620.1_5'UTR	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						AAGATCAATTCATGATTCAAG	0.348000													15	24					0	0	1	0	0
TMEM245	23731	broad.mit.edu	37	9	111812952	111812952	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111812952G>A	ENST00000374586.3	-	13	1906	c.1875C>T	c.(1873-1875)atC>atT	p.I625I		NM_032012.3	NP_114401.2	Q9H330	CI005_HUMAN	transmembrane protein 245	625						integral to membrane											GGCTCATAACGATCCACAGAG	0.458000													15	37					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48269841	48269841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48269841C>T	ENST00000225964.5	-	29	2096	c.1978G>A	c.(1978-1980)Gaa>Aaa	p.E660K		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	660	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	CTTACCTGTTCACCAGGTTTG	0.582000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						9	21					0	0	1	0	0
G6PD	2539	broad.mit.edu	37	X	153761272	153761272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153761272G>A	ENST00000393562.2	-	9	1409	c.1026C>T	c.(1024-1026)ccC>ccT	p.P342P	G6PD_ENST00000369620.2_Silent_p.P358P|G6PD_ENST00000393564.2_Silent_p.P312P	NM_000402.3	NP_000393.4	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase	312			L -> F (in Chinese-5).		cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(3)|ovary(4)	18	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTCTCCATCGGGGTTCCCCA	0.612000													8	60					0	0	1	0	0
TMPPE	643853	broad.mit.edu	37	3	33134930	33134930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33134930G>A	ENST00000342462.4	-	2	948	c.758C>T	c.(757-759)tCg>tTg	p.S253L	GLB1_ENST00000399402.3_Intron|GLB1_ENST00000307377.8_Intron|GLB1_ENST00000445488.2_Intron|TMPPE_ENST00000416695.2_Missense_Mutation_p.S116L|GLB1_ENST00000307363.5_Intron	NM_001039770.2	NP_001034859.2	Q6ZT21	TMPPE_HUMAN	transmembrane protein with metallophosphoesterase domain	253						integral to membrane	metal ion binding			breast(1)|large_intestine(5)|lung(6)|prostate(1)	13						CCGCAGGACCGAGGCTTCTGA	0.547000													24	97					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38927686	38927686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38927686C>T	ENST00000302328.3	-	16	3077	c.2879G>A	c.(2878-2880)aGa>aAa	p.R960K	SCN11A_ENST00000456224.3_Intron|SCN11A_ENST00000444237.2_Missense_Mutation_p.R960K|SCN11A_ENST00000450244.1_Missense_Mutation_p.R960K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	960					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ACTTTGAACTCTCTGGCTCGT	0.448000													21	61					0	0	1	0	0
TRIM35	23087	broad.mit.edu	37	8	27151776	27151776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27151776G>A	ENST00000305364.4	-	3	666	c.583C>T	c.(583-585)Cgc>Tgc	p.R195C	TRIM35_ENST00000521253.1_Missense_Mutation_p.R163C	NM_171982.3	NP_741983.2	Q9UPQ4	TRI35_HUMAN	tripartite motif containing 35	195					apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding	p.R195C(1)		breast(1)|endometrium(6)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	14		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		AAGAACTCGCGAAGCTTATCA	0.577000													14	58					0	0	1	0	0
PYROXD1	79912	broad.mit.edu	37	12	21614955	21614955	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21614955C>T	ENST00000538582.1	+	9	1434	c.681C>T	c.(679-681)gtC>gtT	p.V227V	PYROXD1_ENST00000545178.1_3'UTR|PYROXD1_ENST00000240651.9_Silent_p.V298V			Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 1	298							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|soft_tissue(1)	18						TGTGGCCTGTCTATGTGGAAT	0.368000													27	48					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21205122	21205122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21205122G>A	ENST00000381541.3	+	10	1489	c.1424G>A	c.(1423-1425)gGa>gAa	p.G475E	LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.G428E|SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.G475E																							CCCGTCTGTGGAAACAATGGA	0.378000													37	96					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151509770	151509770	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151509770C>T	ENST00000271636.7	+	21	3693	c.3560C>T	c.(3559-3561)tCg>tTg	p.S1187L		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	1181	Tail.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TACGATCCCTCGTCCATTGCA	0.552000													19	65					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52714852	52714852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52714852C>T	ENST00000293670.3	-	1	330	c.268G>A	c.(268-270)Gag>Aag	p.E90K		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	90	Head.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGAGGCTCTCGTTGACCGAC	0.667000													32	108					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75036942	75036942	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75036942C>T	ENST00000326665.5	-	14	4670	c.4452G>A	c.(4450-4452)agG>agA	p.R1484R	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1484	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GACTCAATTCCCTCTCTCCCT	0.542000													69	159					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10648094	10648094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10648094C>T	ENST00000547195.1	-	8	1014	c.514G>A	c.(514-516)Gac>Aac	p.D172N	MRVI1_ENST00000531107.1_Missense_Mutation_p.D255N|MRVI1_ENST00000552103.1_Missense_Mutation_p.D172N|MRVI1_ENST00000421747.1_Missense_Mutation_p.D254N|MRVI1_ENST00000558540.1_5'UTR|MRVI1_ENST00000527509.2_Missense_Mutation_p.D172N|MRVI1_ENST00000545852.1_5'UTR|MRVI1_ENST00000436272.1_Missense_Mutation_p.D236N|MRVI1_ENST00000541483.1_Intron|MRVI1_ENST00000423302.2_Missense_Mutation_p.D263N|MRVI1_ENST00000424001.1_5'UTR|MRVI1_ENST00000534266.2_5'UTR	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	236	Interaction with PRKG1 (By similarity).				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTCCTCTGGTCATTCTGCTTC	0.532000													8	21					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35245491	35245491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:35245491G>A	ENST00000360310.1	-	18	3034	c.2467C>T	c.(2467-2469)Ctc>Ttc	p.L823F	BAZ1A_ENST00000382422.2_Missense_Mutation_p.L823F|BAZ1A_ENST00000358716.4_Missense_Mutation_p.L791F	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	823	Interaction with SMARCA5.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TCAATAAAGAGTCCAGGAATA	0.413000													46	94					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129249780	129249780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129249780G>A	ENST00000296271.3	+	2	517	c.423G>A	c.(421-423)aaG>aaA	p.K141K		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	141					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	TGGTGTGTAAGCCCATGAGCA	0.637000													47	166					0	0	1	0	0
PLBD1	79887	broad.mit.edu	37	12	14706316	14706316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14706316G>A	ENST00000240617.5	-	2	798	c.146C>T	c.(145-147)cCt>cTt	p.P49L		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	49					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						CTTTTCAGCAGGCATCCAGTA	0.408000													19	90					0	0	1	0	0
BANP	54971	broad.mit.edu	37	16	88066771	88066771	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:88066771C>T	ENST00000393207.1	+	9	1317	c.1096C>T	c.(1096-1098)Ccg>Tcg	p.P366S	BANP_ENST00000355163.5_Missense_Mutation_p.P341S|BANP_ENST00000393208.2_Missense_Mutation_p.P335S|BANP_ENST00000286122.7_Missense_Mutation_p.P366S|BANP_ENST00000538234.1_Missense_Mutation_p.P374S|BANP_ENST00000479780.2_Missense_Mutation_p.P335S|BANP_ENST00000355022.4_Missense_Mutation_p.P335S	NM_001173543.1	NP_001167014.1	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein	366	DNA-binding (By similarity).|Gln-rich.				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.00551)		ACAGCCGCAGCCGCAGGCCCT	0.627000													7	27					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35551382	35551382	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35551382G>A	ENST00000262626.2	+	8	1411	c.586G>A	c.(586-588)Gac>Aac	p.D196N	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Intron|HPN_ENST00000392226.1_Missense_Mutation_p.D196N	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	196	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity	p.D196Y(1)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GCTCTCCGGGGACTGGGTGCT	0.672000													37	95					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16032714	16032714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16032714G>A	ENST00000350896.3	-	3	396	c.199C>T	c.(199-201)Ctc>Ttc	p.L67F	MSR1_ENST00000445506.2_Missense_Mutation_p.L85F|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000381998.4_Missense_Mutation_p.L67F|MSR1_ENST00000262101.5_Missense_Mutation_p.L67F|MSR1_ENST00000355282.2_Missense_Mutation_p.L67F	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	67					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTCCAATGAGAGGGATGAGA	0.418000													7	81					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53421577	53421577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53421577C>T	ENST00000262056.9	+	7	1005	c.679C>T	c.(679-681)Cgt>Tgt	p.R227C	EIF4B_ENST00000420463.3_Missense_Mutation_p.R227C|RP11-983P16.4_ENST00000552905.1_RNA|EIF4B_ENST00000416762.3_Missense_Mutation_p.R188C	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	227	Arg-rich.|Asp-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity	p.R227C(1)		breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						GTATCGAGATCGTTATGATTC	0.483000													22	133					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970347	101970347	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:101970347C>T	ENST00000543253.1	+	5	1469	c.550C>T	c.(550-552)Cct>Tct	p.P184S	GPRASP2_ENST00000332262.5_Missense_Mutation_p.P184S|GPRASP2_ENST00000535209.1_Missense_Mutation_p.P184S	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						TGAAACCTTTCCTGGCACCCA	0.532000													78	43					0	0	1	0	0
PTGDS	5730	broad.mit.edu	37	9	139873744	139873744	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139873744G>A	ENST00000224167.2	+	3	399	c.324G>A	c.(322-324)cgG>cgA	p.R108R	PTGDS_ENST00000371625.3_Silent_p.R108R|PTGDS_ENST00000460340.1_3'UTR			P41222	PTGDS_HUMAN	prostaglandin D2 synthase 21kDa (brain)	108					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ACAGCTACCGGAGTCCCCGTG	0.692000													23	63					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156819153	156819153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156819153G>A	ENST00000368195.3	-	6	1725	c.1329C>T	c.(1327-1329)gcC>gcT	p.A443A	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	443					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCGGGTTGAAGGCGAAGTAGA	0.602000													43	106					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665972	19665972	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19665972G>A	ENST00000328041.6	+	12	1488	c.1291G>A	c.(1291-1293)Gat>Aat	p.D431N		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	431						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						cgaggatgatgatgaagGACC	0.512000													31	62					0	0	1	0	0
DUSP26	78986	broad.mit.edu	37	8	33454988	33454988	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:33454988G>A	ENST00000256261.4	-	2	563	c.46C>T	c.(46-48)Cgc>Tgc	p.R16C	DUSP26_ENST00000523956.1_Missense_Mutation_p.R16C	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	16						Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		CGGGAGAAGCGGGCCATAAAA	0.542000													7	39					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2191098	2191098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2191098G>A	ENST00000381178.1	-	3	205	c.187C>T	c.(187-189)Ccg>Tcg	p.P63S	TH_ENST00000352909.3_Missense_Mutation_p.P32S|TH_ENST00000333684.5_Missense_Mutation_p.P36S|TH_ENST00000381175.1_Missense_Mutation_p.P59S	NM_199292.2	NP_954986.2	P07101	TY3H_HUMAN	tyrosine hydroxylase	63					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(7)|skin(1)	11		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	ATGAACCGCGGGGACTGTGGG	0.716000													4	12					0	0	1	0	0
DUPD1	338599	broad.mit.edu	37	10	76803681	76803681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76803681C>T	ENST00000338487.5	-	2	294	c.295G>A	c.(295-297)Gac>Aac	p.D99N		NM_001003892.1	NP_001003892.1	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase domain containing 1	99	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CGGTAGTAGTCGGGCCCAGTG	0.667000													31	55					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94946066	94946066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94946066C>T	ENST00000222381.3	-	3	412	c.181G>A	c.(181-183)Gga>Aga	p.G61R	PON1_ENST00000542556.1_Missense_Mutation_p.G61R	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	61					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AAAGCCAGTCCATTAGGCAGT	0.403000													35	148					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61932087	61932087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61932087G>A	ENST00000280772.1	-	21	2648	c.2457C>T	c.(2455-2457)acC>acT	p.T819T	ANK3_ENST00000503366.1_Silent_p.T802T|ANK3_ENST00000373827.2_Silent_p.T813T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	819					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGGTCTCTTCGGTCACTATCT	0.483000													19	75					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75829083	75829083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:75829083C>T	ENST00000322507.8	-	45	7502	c.7193G>A	c.(7192-7194)gGa>gAa	p.G2398E	COL12A1_ENST00000345356.6_Missense_Mutation_p.G1234E|COL12A1_ENST00000483888.2_Missense_Mutation_p.G2398E|COL12A1_ENST00000416123.2_Missense_Mutation_p.G2398E	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2398	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TGTGTTTCCTCCTCTGTACCT	0.438000													18	142					0	0	1	0	0
RTF1	23168	broad.mit.edu	37	15	41769408	41769408	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41769408C>T	ENST00000389629.4	+	13	1618	c.1606C>T	c.(1606-1608)Caa>Taa	p.Q536*		NM_015138.4	NP_055953.3	Q92541	RTF1_HUMAN	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	536					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	18		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		CAAACAAATCCAAGATCAACT	0.512000													47	179					0	0	1	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123215752	123215752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123215752G>A	ENST00000349780.4	-	21	2954	c.2775C>T	c.(2773-2775)ctC>ctT	p.L925L	CDK5RAP2_ENST00000359309.3_Silent_p.L925L|CDK5RAP2_ENST00000360822.3_Silent_p.L893L|CDK5RAP2_ENST00000360190.4_Silent_p.L925L	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	925					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						TAATACCAGGGAGGGAAAGGA	0.453000													36	90					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12725998	12725998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12725998C>T	ENST00000376221.1	+	4	476	c.476C>T	c.(475-477)tCc>tTc	p.S159F		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	159						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GACCACCATTCCCCTGCCCTT	0.527000													24	86					0	0	1	0	0
MATN2	4147	broad.mit.edu	37	8	99039822	99039822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:99039822C>T	ENST00000254898.5	+	14	2352	c.2121C>T	c.(2119-2121)ttC>ttT	p.F707F	RPL30_ENST00000518164.1_Intron|MATN2_ENST00000522025.2_Silent_p.F423F|MATN2_ENST00000524308.1_Silent_p.F666F|MATN2_ENST00000521689.1_Silent_p.F707F|MATN2_ENST00000520016.1_Silent_p.F707F	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	707	VWFA 2.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			ACACAGAGTTCACTCTGAGAA	0.488000													10	51					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19770234	19770234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:19770234C>T	ENST00000284885.3	-	3	339	c.306G>A	c.(304-306)ctG>ctA	p.L102L		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	102	SEA.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						ATTCATTCTTCAGATTGCTTG	0.239000													5	22					0	0	1	0	0
KCTD18	130535	broad.mit.edu	37	2	201371607	201371607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:201371607G>A	ENST00000359878.3	-	2	643	c.133C>T	c.(133-135)Cgc>Tgc	p.R45C	KCTD18_ENST00000409157.1_Missense_Mutation_p.R45C|KCTD18_ENST00000468413.1_5'UTR	NM_152387.2	NP_689600.2	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain containing 18	45	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						AGAGGAAAGCGACCACTGAAC	0.433000													27	58					0	0	1	0	0
DDX20	11218	broad.mit.edu	37	1	112305305	112305305	+	Missense_Mutation	SNP	C	C	T	rs61755354		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112305305C>T	ENST00000369702.4	+	9	1731	c.1111C>T	c.(1111-1113)Cgt>Tgt	p.R371C	DDX20_ENST00000536167.1_3'UTR|DDX20_ENST00000475700.1_5'UTR	NM_007204.4	NP_009135.4	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	371	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAGACTTCTCGTGGGATTGA	0.403000													17	125					0	0	1	0	0
T	6862	broad.mit.edu	37	6	166581001	166581001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:166581001C>T	ENST00000296946.2	-	2	547	c.79G>A	c.(79-81)Gag>Aag	p.E27K	T_ENST00000366871.3_Missense_Mutation_p.E27K	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	27					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GCCTGCAGCTCATTCTCCACG	0.682000									Chordoma, Familial Clustering of				7	9					0	0	1	0	0
UBL7	84993	broad.mit.edu	37	15	74740913	74740913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74740913G>A	ENST00000567435.1	-	10	1374	c.911C>T	c.(910-912)tCc>tTc	p.S304F	UBL7_ENST00000565335.1_Missense_Mutation_p.S304F|UBL7_ENST00000564488.1_Missense_Mutation_p.S304F|UBL7_ENST00000395081.2_Missense_Mutation_p.S304F|UBL7_ENST00000361351.4_Missense_Mutation_p.S304F			Q96S82	UBL7_HUMAN	ubiquitin-like 7 (bone marrow stromal cell-derived)	304							protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9						GACACCAGAGGACATTGGTGA	0.552000													79	293					0	0	1	0	0
IGHV7-81	28378	broad.mit.edu	37	14	107283249	107283249	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107283249G>A	ENST00000390639.2	-	0	31																											TGCTCTAGGGGATTCTCCCAA	0.507000													27	49					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16918926	16918926	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16918926G>A	ENST00000524140.2	+	18	4684	c.4266G>A	c.(4264-4266)tgG>tgA	p.W1422*	NWD1_ENST00000523826.1_Nonsense_Mutation_p.W1216*|NWD1_ENST00000379808.3_Nonsense_Mutation_p.W1422*|NWD1_ENST00000339803.6_Nonsense_Mutation_p.W1287*|NWD1_ENST00000552788.1_Nonsense_Mutation_p.W1422*|NWD1_ENST00000549814.1_Nonsense_Mutation_p.W1380*	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1422							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CACGCAAGTGGAAATTCGAGA	0.567000													23	51					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43351612	43351612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43351612C>T	ENST00000395891.1	+	4	883	c.278C>T	c.(277-279)tCt>tTt	p.S93F	HECW1_ENST00000453890.1_Missense_Mutation_p.S93F	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	93					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						ATCGGGCACTCTCAGGACCTG	0.567000													26	74					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72946126	72946126	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72946126C>T	ENST00000311131.2	+	3	1389	c.922C>T	c.(922-924)Ctg>Ttg	p.L308L	P2RY2_ENST00000393597.2_Silent_p.L308L|P2RY2_ENST00000393596.2_Silent_p.L308L	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	308					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	GCTCTACTTCCTGGCTGGGCA	0.662000													9	29					0	0	1	0	0
ZNF512B	57473	broad.mit.edu	37	20	62594450	62594450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62594450G>A	ENST00000450537.1	-	12	2026	c.1966C>T	c.(1966-1968)Ccc>Tcc	p.P656S	ZNF512B_ENST00000217130.3_Missense_Mutation_p.P656S|ZNF512B_ENST00000369888.1_Missense_Mutation_p.P656S			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	656					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCACTCACGGGGGCCGTGTGC	0.622000													3	8					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	51053096	51053096	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:51053096G>A	ENST00000442544.2	+	28	4837	c.4221G>A	c.(4219-4221)gaG>gaA	p.E1407E	RP11-671P2.1_ENST00000582064.1_RNA|DCC_ENST00000581580.1_Silent_p.E1040E	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1407					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AAGTGTCTGAGGAGAGCCACA	0.483000													8	89					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703417	4703417	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4703417G>A	ENST00000396950.3	-	2	764	c.525C>T	c.(523-525)caC>caT	p.H175H		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CACAATAGGAGTGCGAGAGGA	0.532000													28	70					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129929579	129929579	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129929579C>T	ENST00000222481.4	+	11	1307	c.1252C>T	c.(1252-1254)Ccc>Tcc	p.P418S		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	418					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					GCGAGACCACCCCTATTAGGG	0.522000													28	64					0	0	1	0	0
TBK1	29110	broad.mit.edu	37	12	64854024	64854024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:64854024C>T	ENST00000331710.5	+	3	482	c.143C>T	c.(142-144)cCa>cTa	p.P48L		NM_013254.3	NP_037386.1	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	48	Protein kinase.				I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)	20				GBM - Glioblastoma multiforme(28;0.0386)		TTCCTTCGTCCAGTGGATGTT	0.269000													32	62					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219249890	219249890	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219249890G>A	ENST00000233202.6	+	4	634	c.294G>A	c.(292-294)tgG>tgA	p.W98*	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	98					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCTGCTCTGGGCCACCGTGT	0.622000													9	90					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005674	74005674	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74005674C>T	ENST00000301607.3	-	22	3865	c.3612G>A	c.(3610-3612)ccG>ccA	p.P1204P	EVPL_ENST00000586740.1_Silent_p.P1226P	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1204	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCTCTGTCTCCGGATCCACCT	0.627000													28	64					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28983403	28983403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28983403G>A	ENST00000359747.4	+	11	1471	c.1442G>A	c.(1441-1443)gGa>gAa	p.G481E	DSG4_ENST00000308128.4_Missense_Mutation_p.G481E|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	481	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACAGCTACAGGAACCATATGT	0.398000													13	26					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158609717	158609717	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158609717G>A	ENST00000368148.3	-	34	4998	c.4818C>T	c.(4816-4818)gcC>gcT	p.A1606A	SPTA1_ENST00000368147.3_Silent_p.A1606A	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1606					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTGACGACTGGCCTCATTGA	0.473000													42	116					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27321123	27321123	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27321123G>A	ENST00000407991.1	-	6	1445	c.837C>T	c.(835-837)atC>atT	p.I279I	CHRNA2_ENST00000520933.2_Silent_p.I279I|CHRNA2_ENST00000240132.2_Silent_p.I264I	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	279			I -> N (in ENFL4; markedly increases receptor sensitivity to acetylcholine).			cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	TGAGGCAGGAGATGAGCAGGC	0.607000													16	44					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233486	21233486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21233486C>T	ENST00000233242.1	-	26	6381	c.6254G>A	c.(6253-6255)cGa>cAa	p.R2085Q		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2085	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATGGTTTGTCGATTCCTCTC	0.348000													21	77					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046521	73046521	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73046521C>T	ENST00000604411.1	+	0	34482				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TTCTATCCTTCCTGGGTTCTG	0.468000													81	52					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7661052	7661052	+	Silent	SNP	T	T	G	rs56030009		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7661052T>G	ENST00000299492.4	+	15	1714	c.1326T>G	c.(1324-1326)ccT>ccG	p.P442P	PPFIBP2_ENST00000533792.1_Silent_p.P284P|PPFIBP2_ENST00000530181.1_Silent_p.P299P|PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000528883.1_Silent_p.P330P	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	442					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCAAATCTCCTCCCACCATCT	0.597000													40	136					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133051060	133051060	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133051060T>A	ENST00000262283.5	-	11	1292	c.1193A>T	c.(1192-1194)gAc>gTc	p.D398V	OC90_ENST00000443356.2_Missense_Mutation_p.D202V|OC90_ENST00000254627.3_Missense_Mutation_p.D202V|OC90_ENST00000603859.1_Missense_Mutation_p.D202V			Q02509	OC90_HUMAN	otoconin 90	202	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TGTTGTCAAGTCTTCCTTGAT	0.517000													8	21					0	0	1	0	0
USP8	9101	broad.mit.edu	37	15	50785001	50785001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50785001C>T	ENST00000433963.1	+	16	2838	c.2338C>T	c.(2338-2340)Cgt>Tgt	p.R780C	USP8_ENST00000396444.3_Missense_Mutation_p.R780C|USP8_ENST00000307179.4_Missense_Mutation_p.R780C|USP8_ENST00000425032.3_Missense_Mutation_p.R674C	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	780					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TACTGGACTTCGTAACTTAGG	0.403000													38	107					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50959005	50959005	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50959005C>T	ENST00000374103.4	-	7	861	c.776G>A	c.(775-777)tGg>tAg	p.W259*	OGDHL_ENST00000419399.1_Nonsense_Mutation_p.W202*|OGDHL_ENST00000432695.1_Nonsense_Mutation_p.W50*	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	259					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CTCTGAGGACCATTTCCGGGC	0.562000													5	17					0	0	1	0	0
GPR87	53836	broad.mit.edu	37	3	151012587	151012587	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151012587G>A	ENST00000260843.4	-	3	911	c.447C>T	c.(445-447)gaC>gaT	p.D149D	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron	NM_023915.3	NP_076404.3	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	149						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(6)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	19			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACATCCGAGAGTCCCCAAATG	0.418000													13	62					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645297	52645297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:52645297C>T	ENST00000395961.3	-	4	523	c.357G>A	c.(355-357)gtG>gtA	p.V119V	BCAS1_ENST00000371440.3_Silent_p.V119V|BCAS1_ENST00000371435.2_Silent_p.V119V|BCAS1_ENST00000411563.1_Silent_p.V22V	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	119						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CATCAAGCTTCACTGATCCAA	0.537000													21	64					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7678627	7678627	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7678627C>T	ENST00000572933.1	+	30	6248	c.4788C>T	c.(4786-4788)ttC>ttT	p.F1596F	DNAH2_ENST00000389173.2_Silent_p.F1596F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1596	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACATTGACTTCCTCCACTCAG	0.547000													11	14					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7175787	7175787	+	Missense_Mutation	SNP	G	G	A	rs142773314		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7175787G>A	ENST00000406697.1	+	14	1851	c.1223G>A	c.(1222-1224)aGc>aAc	p.S408N	C1S_ENST00000328916.3_Missense_Mutation_p.S408N|C1S_ENST00000402681.3_Missense_Mutation_p.S241N|C1S_ENST00000360817.5_Missense_Mutation_p.S408N|C1S_ENST00000495061.1_3'UTR			P09871	C1S_HUMAN	complement component 1, s subcomponent	408	Sushi 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GGTAACGGGAGCTGGGTGAAT	0.582000													15	27					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93902868	93902868	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:93902868G>A	ENST00000412050.4	-	6	1417	c.1329C>T	c.(1327-1329)atC>atT	p.I443I	CPEB3_ENST00000265997.4_Silent_p.I457I	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	457	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				AGCTGGCAGTGATCTCATCTA	0.358000													14	35					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74276746	74276746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74276746C>T	ENST00000262765.5	-	10	4131	c.3952G>A	c.(3952-3954)Gag>Aag	p.E1318K		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1318							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						ACATCGATCTCCATCTCCAGG	0.587000													18	78					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87241867	87241867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87241867C>T	ENST00000297524.3	-	1	743	c.640G>A	c.(640-642)Gga>Aga	p.G214R	SLC7A13_ENST00000419776.2_Missense_Mutation_p.G214R|SLC7A13_ENST00000520624.1_Intron	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	214						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						GCAAAATATCCTTGGAAGATG	0.368000													43	100					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171535411	171535411	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171535411A>G	ENST00000367742.3	+	21	6399	c.6157A>G	c.(6157-6159)Act>Gct	p.T2053A	PRRC2C_ENST00000426496.2_Missense_Mutation_p.T2051A|PRRC2C_ENST00000338920.4_Missense_Mutation_p.T2051A|PRRC2C_ENST00000392078.3_Missense_Mutation_p.T2053A			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2051							protein C-terminus binding										CGAAATTGGAACTGACACAAT	0.373000													6	22					0	0	1	0	0
PDCD1	5133	broad.mit.edu	37	2	242794827	242794827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242794827G>A	ENST00000334409.5	-	2	451	c.382C>T	c.(382-384)Ctg>Ttg	p.L128L		NM_005018.2	NP_005009.2	Q15116	PDCD1_HUMAN	programmed cell death 1	128	Ig-like V-type.				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			endometrium(1)|lung(2)|ovary(1)|prostate(3)|skin(1)	8		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		TTGGGGGCCAGGGAGATGGCC	0.677000													15	41					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31606075	31606075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31606075C>T	ENST00000170150.3	+	8	783	c.588C>T	c.(586-588)ccC>ccT	p.P196P		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	196						extracellular region	lipid binding										GCCTCAACCCCGTGGGTCCTG	0.478000													18	73					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101868335	101868335	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101868335G>A	ENST00000263468.8	+	11	3585	c.3315G>A	c.(3313-3315)aaG>aaA	p.K1105K	KIAA1377_ENST00000537689.1_Silent_p.K906K	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	1105							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TCCAGGAGAAGAGAGAAGATA	0.428000													7	78					0	0	1	0	0
PEG10	23089	broad.mit.edu	37	7	94293537	94293537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94293537C>T	ENST00000482108.1	+	2	1148	c.669C>T	c.(667-669)gtC>gtT	p.V223V	PEG10_ENST00000488574.1_Silent_p.V223V	NM_001040152.1|NM_001172438.1|NM_001184962.1	NP_001035242.1|NP_001165909.1|NP_001171891.1	Q86TG7	PEG10_HUMAN	paternally expressed 10	223	Necessary for interaction with ALK1.				apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding	p.V223V(1)		NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(9)|prostate(3)|skin(1)	21	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			ACCTCGAGGTCGCCAAGTCGC	0.627000													48	55					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119953070	119953070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119953070C>T	ENST00000307142.4	+	4	3336	c.3140C>T	c.(3139-3141)tCc>tTc	p.S1047F	SYNPO2_ENST00000434046.2_Missense_Mutation_p.S1047F|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Missense_Mutation_p.S1047F	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	1047						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GTCAGTGCATCCCCAGTGCCT	0.532000													19	53					0	0	1	0	0
RNF10	9921	broad.mit.edu	37	12	120992561	120992561	+	Missense_Mutation	SNP	C	C	T	rs138704590		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120992561C>T	ENST00000325954.4	+	4	1056	c.595C>T	c.(595-597)Cat>Tat	p.H199Y	RNF10_ENST00000413266.2_Missense_Mutation_p.H199Y	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	199					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTACACAGCTCATTTTGCTGA	0.428000													40	149					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38531037	38531037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38531037G>A	ENST00000332509.3	-	6	1035	c.852C>T	c.(850-852)ccC>ccT	p.P284P	PLA2G6_ENST00000402064.1_Silent_p.P284P|PLA2G6_ENST00000335539.3_Silent_p.P284P	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	284					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	CTCCGTAACGGGGGTCTTTGC	0.657000													20	58					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058960	152058960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152058960G>A	ENST00000368806.1	-	3	1262	c.1198C>T	c.(1198-1200)Cat>Tat	p.H400Y		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	400							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GCTGTTCCATGGGCCTCAGGA	0.473000													68	160					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70064186	70064186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70064186C>T	ENST00000370598.1	+	27	4342	c.3521C>T	c.(3520-3522)tCg>tTg	p.S1174L	BAI3_ENST00000546190.1_Missense_Mutation_p.S138L|BAI3_ENST00000238918.8_Missense_Mutation_p.S380L	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1174	Poly-Ser.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GCAGATTCTTCGAGTTCGTTT	0.393000													61	68					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489255	237489255	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237489255C>T	ENST00000272928.3	+	2	457	c.147C>T	c.(145-147)ttC>ttT	p.F49F		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		CGCTCTCCTTCATTTACATTT	0.527000													8	20					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103787	53103787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:53103787C>T	ENST00000408890.4	+	1	439	c.423C>T	c.(421-423)atC>atT	p.I141I		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	141										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCATCGGGATCGCGCCCCCTG	0.716000													19	42					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5890243	5890243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:5890243G>A	ENST00000581347.1	-	3	2465	c.1820C>T	c.(1819-1821)tCt>tTt	p.S607F	TMEM200C_ENST00000383490.2_Missense_Mutation_p.S607F|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	607						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						TATGGCATGAGACCTGGAAAT	0.547000													38	100					0	0	1	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249106434	249106434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:249106434G>A	ENST00000366472.5	-	7	2076	c.847C>T	c.(847-849)Ccc>Tcc	p.P283S	SH3BP5L_ENST00000475978.1_5'UTR|SH3BP5L_ENST00000411742.2_Missense_Mutation_p.P251S	NM_030645.1	NP_085148.1	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	283										endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGGCCCAGGGGGTGGGGAGGC	0.716000													6	21					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435305	18435305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18435305C>T	ENST00000433979.1	+	2	406	c.290C>T	c.(289-291)tCc>tTc	p.S97F	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.S97F|RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.S97F|PIK3C2G_ENST00000535651.1_Missense_Mutation_p.S97F	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	97					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CGTGAACTCTCCTGGCATCAA	0.423000													30	115					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712534	121712534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121712534G>A	ENST00000273691.3	-	6	1035	c.930C>T	c.(928-930)ctC>ctT	p.L310L	ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000462014.1_Silent_p.L322L|ILDR1_ENST00000344209.5_Silent_p.L354L|ILDR1_ENST00000393631.1_Silent_p.L265L	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	354						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GAATTGGGGTGAGCCACTGCT	0.602000													15	35					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52822006	52822006	+	Silent	SNP	C	C	T	rs145881645	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52822006C>T	ENST00000273283.2	+	17	1953	c.1929C>T	c.(1927-1929)ttC>ttT	p.F643F	ITIH1_ENST00000405128.3_Silent_p.F9F|ITIH1_ENST00000537050.1_Silent_p.F355F|ITIH1_ENST00000542827.1_Intron|ITIH1_ENST00000540715.1_Silent_p.F501F	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	643	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity	p.F643L(1)|p.F643F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		CATCAGCGTTCGTGCTGTCAG	0.612000													38	121					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936693	4936693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4936693G>A	ENST00000322013.3	-	1	229	c.201C>T	c.(199-201)ttC>ttT	p.F67F	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCATGGACAGGAAGAGATACA	0.478000													18	40					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171092543	171092543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171092543C>T	ENST00000334231.6	+	7	673	c.673C>T	c.(673-675)Cgc>Tgc	p.R225C	MYO3B_ENST00000408978.4_Missense_Mutation_p.R216C|MYO3B_ENST00000409044.3_Missense_Mutation_p.R216C|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	216	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						CTATGACGCTCGCTGTGACGT	0.493000											OREG0014376	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	110					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196759830	196759830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196759830G>A	ENST00000312428.6	-	30	4866	c.4766C>T	c.(4765-4767)tCc>tTc	p.S1589F		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1589	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATCTTCTCGGAAAAGAATGC	0.368000													24	61					0	0	1	0	0
LRRC10	376132	broad.mit.edu	37	12	70003892	70003892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70003892C>T	ENST00000361484.3	-	1	1050	c.727G>A	c.(727-729)Gag>Aag	p.E243K		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	243						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TCTGGCGTCTCCTCTGCCCAT	0.582000													15	63					0	0	1	0	0
MYOG	4656	broad.mit.edu	37	1	203054976	203054976	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203054976C>T	ENST00000241651.4	-	1	188	c.114G>A	c.(112-114)acG>acA	p.T38T		NM_002479.4	NP_002470.2	P15173	MYOG_HUMAN	myogenin (myogenic factor 4)	38					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|urinary_tract(1)	12						GGGTGAGCTCCGTCCGCTCGT	0.652000													20	48					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109707915	109707915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109707915C>T	ENST00000356711.2	+	27	3367	c.3241C>T	c.(3241-3243)Cgc>Tgc	p.R1081C	MYO16_ENST00000457511.2_Missense_Mutation_p.R593C|MYO16_ENST00000357550.2_Missense_Mutation_p.R1081C	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1081	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATACCCTGTTCGCCTTTCCTT	0.433000													29	132					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59272864	59272864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:59272864G>A	ENST00000320743.3	-	14	2111	c.1825C>T	c.(1825-1827)Ccc>Tcc	p.P609S	LRIG3_ENST00000379141.4_Missense_Mutation_p.P549S	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	609	Ig-like C2-type 2.					integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			AGATCCATGGGGGTCTTGGTG	0.527000			T	ROS1	NSCLC								19	30					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14563098	14563098	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14563098C>T	ENST00000273083.3	-	0	778							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CACCTCCCCCCATCCCAGGCC	0.582000													6	8					0	0	1	0	0
KRT38	8687	broad.mit.edu	37	17	39597070	39597070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39597070C>T	ENST00000246646.3	-	1	103	c.104G>A	c.(103-105)gGg>gAg	p.G35E		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	35	Head.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				GGCCTCTGCCCCAGGCTGGCA	0.617000													18	39					0	0	1	0	0
EYA2	2139	broad.mit.edu	37	20	45633599	45633599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45633599C>T	ENST00000327619.5	+	4	548	c.174C>T	c.(172-174)ctC>ctT	p.L58L	EYA2_ENST00000317304.6_Silent_p.L58L|EYA2_ENST00000357410.3_Silent_p.L58L	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	58					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				CACGTGTCCTCCCCCGCCAGC	0.572000													18	119					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650730	179650730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179650730C>T	ENST00000589042.1	-	14	2439	c.2215G>A	c.(2215-2217)Gaa>Aaa	p.E739K	TTN_ENST00000342992.6_Missense_Mutation_p.E739K|TTN_ENST00000360870.5_Missense_Mutation_p.E739K|TTN_ENST00000460472.2_Missense_Mutation_p.E693K|TTN_ENST00000342175.6_Missense_Mutation_p.E693K|TTN_ENST00000359218.5_Missense_Mutation_p.E693K|TTN_ENST00000591111.1_Missense_Mutation_p.E739K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	739							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAATGCGTTCCTTATATCCG	0.552000													29	69					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54913107	54913107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54913107C>T	ENST00000293373.6	+	16	1695	c.1616C>T	c.(1615-1617)tCt>tTt	p.S539F	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.S489F	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	539					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TCTGATCTGTCTACTTTCTGG	0.383000													35	98					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76397922	76397922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76397922C>T	ENST00000357063.3	+	16	4278	c.3018C>T	c.(3016-3018)gcC>gcT	p.A1006A	LMO7_ENST00000341547.4_Silent_p.A672A|LMO7_ENST00000377534.3_Silent_p.A1006A|LMO7_ENST00000321797.8_Silent_p.A721A|LMO7_ENST00000465261.2_Silent_p.A721A|LMO7_ENST00000526202.1_Silent_p.A571A			Q8WWI1	LMO7_HUMAN	LIM domain 7	1006						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		CTTCTAAAGCCACATTGTCTT	0.473000													8	71					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101818765	101818765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101818765C>T	ENST00000263468.8	+	4	668	c.398C>T	c.(397-399)tCc>tTc	p.S133F		NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	133							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TCTTTAGTTTCCCGAAAACCA	0.333000													9	66					0	0	1	0	0
MKKS	8195	broad.mit.edu	37	20	10393290	10393290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:10393290G>A	ENST00000347364.2	-	3	1635	c.873C>T	c.(871-873)gtC>gtT	p.V291V		NM_170784.2	NP_740754.1	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome	291	Substrate-binding apical domain.				brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding			kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|stomach(2)	16						TTTGGCACAGGACAAGATCTA	0.438000													30	80					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79326248	79326248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79326248C>T	ENST00000376718.3	-	8	1065	c.942G>A	c.(940-942)caG>caA	p.Q314Q	PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	314					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GGCAAGGGTTCTGACACTCTT	0.488000													10	13					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124385898	124385898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124385898C>T	ENST00000360013.3	+	47	6695	c.6568C>T	c.(6568-6570)Ccc>Tcc	p.P2190S	KALRN_ENST00000428018.2_Missense_Mutation_p.P461S|KALRN_ENST00000291478.4_Missense_Mutation_p.P493S|KALRN_ENST00000393496.1_Missense_Mutation_p.P531S|KALRN_ENST00000459915.1_Missense_Mutation_p.P282S	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2189	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GGACAATGATCCCTGCAAGTT	0.433000													29	74					0	0	1	0	0
TGFBI	7045	broad.mit.edu	37	5	135389715	135389715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135389715C>T	ENST00000442011.2	+	9	1371	c.1210C>T	c.(1210-1212)Ctc>Ttc	p.L404F	TGFBI_ENST00000305126.8_Missense_Mutation_p.L404F	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	404	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CGGCAATCATCTCTCTGGAAG	0.507000													31	126					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17353254	17353254	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:17353254G>A	ENST00000261381.6	-	3	588	c.504C>T	c.(502-504)ttC>ttT	p.F168F		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	168					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCCTGGGTGCGAAGTTGCTGT	0.498000													28	98					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6228309	6228309	+	Silent	SNP	G	G	A	rs146996909	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6228309G>A	ENST00000262450.3	-	2	207	c.108C>T	c.(106-108)ttC>ttT	p.F36F	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	36					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding	p.F36F(1)		breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AAAAGTCATCGAAGGCTTCAA	0.498000													84	189					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164679	139164679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139164679G>A	ENST00000395297.1	-	13	2209	c.2039C>T	c.(2038-2040)tCa>tTa	p.S680L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	680										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TATGATGGATGAAGATCTCTT	0.537000										HNSCC(54;0.14)			9	100					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382554	152382554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152382554C>T	ENST00000271835.3	-	3	1066	c.1004G>A	c.(1003-1005)aGg>aAg	p.R335K	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	335	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGTCTGGCTCCTGCCTTGACC	0.592000													74	190					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532019	50532019	+	Missense_Mutation	SNP	G	G	A	rs141342139	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50532019G>A	ENST00000374144.3	+	3	1717	c.1429G>A	c.(1429-1431)Gga>Aga	p.G477R	C10orf71_ENST00000323868.4_Missense_Mutation_p.G477R			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	477										endometrium(1)	1						ACAGCTAAACGGATACCAAGA	0.572000													7	26					0	0	1	0	0
CDK1	983	broad.mit.edu	37	10	62552004	62552004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:62552004C>T	ENST00000448257.2	+	7	953	c.752C>T	c.(751-753)tCc>tTc	p.S251F	CDK1_ENST00000395284.3_Missense_Mutation_p.S251F|CDK1_ENST00000373809.2_Missense_Mutation_p.S194F|CDK1_ENST00000316629.4_Missense_Mutation_p.S194F			P06493	CDK1_HUMAN	cyclin-dependent kinase 1	251	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|axon guidance|cell division|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|mitosis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein localization to kinetochore|Ras protein signal transduction|regulation of transcription involved in G1/S phase of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|midbody|nucleoplasm|spindle microtubule	ATP binding|cyclin-dependent protein kinase activity|RNA polymerase II carboxy-terminal domain kinase activity			ovary(1)	1						AGCCTAGCATCCCATGTCAAA	0.403000													27	53					0	0	1	0	0
PLA2G7	7941	broad.mit.edu	37	6	46672983	46672983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46672983C>T	ENST00000274793.7	-	11	1292	c.1096G>A	c.(1096-1098)Gga>Aga	p.G366R	PLA2G7_ENST00000537365.1_Missense_Mutation_p.G366R	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	366					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			AGCATGTGTCCAATTATTTTG	0.333000													9	64					0	0	1	0	0
STMN4	81551	broad.mit.edu	37	8	27097571	27097571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27097571C>T	ENST00000350889.4	-	6	621	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K	STMN4_ENST00000265770.7_Missense_Mutation_p.E143K|STMN4_ENST00000519997.1_Missense_Mutation_p.E134K|STMN4_ENST00000522908.1_Missense_Mutation_p.E170K|STMN4_ENST00000519614.1_Missense_Mutation_p.E143K|STMN4_ENST00000523048.1_Missense_Mutation_p.E170K	NM_030795.2	NP_110422.2	Q9H169	STMN4_HUMAN	stathmin-like 4	143					intracellular signal transduction					endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)	11		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		GCCAGTTTTTCCTTAGCCATC	0.527000													28	76					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903186	4903186	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4903186C>T	ENST00000380378.1	+	1	138	c.138C>T	c.(136-138)ttC>ttT	p.F46F	MMP26_ENST00000380390.1_Intron|OR51T1_ENST00000322049.1_Silent_p.F19F|MMP26_ENST00000477339.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCACTGCATTCCCTGGGCTGG	0.423000													37	84					0	0	1	0	0
MFSD10	10227	broad.mit.edu	37	4	2935555	2935555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:2935555G>A	ENST00000329687.4	-	1	630	c.96C>T	c.(94-96)ctC>ctT	p.L32L	MFSD10_ENST00000508221.1_Silent_p.L32L|MFSD10_ENST00000514800.1_Silent_p.L32L|MFSD10_ENST00000507555.1_Silent_p.L32L|MFSD10_ENST00000355443.4_Silent_p.L32L	NM_001120.4	NP_001111.3	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing 10	32					apoptosis	integral to membrane	tetracycline transporter activity			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GGTCCAGCAGGAGGCCGAGAA	0.716000													4	4					0	0	1	0	0
RYK	6259	broad.mit.edu	37	3	133894509	133894509	+	Missense_Mutation	SNP	G	G	A	rs144378986	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133894509G>A	ENST00000427044.2	-	14	1562	c.952C>T	c.(952-954)Cgt>Tgt	p.R318C	RYK_ENST00000296084.4_Missense_Mutation_p.R508C			P34925	RYK_HUMAN	receptor-like tyrosine kinase	504					corpus callosum development|positive regulation of MAPKKK cascade|Wnt receptor signaling pathway	cytoplasm|integral to plasma membrane|nucleus	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(1)|ovary(3)	4						GCCATCCAACGAACTGGCCTG	0.473000													65	136					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903121	4903121	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4903121C>T	ENST00000380378.1	+	1	73	c.73C>T	c.(73-75)Caa>Taa	p.Q25*	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCAGTGTCTTCAACCAACCAT	0.338000													21	55					0	0	1	0	0
SULT1E1	6783	broad.mit.edu	37	4	70721023	70721023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70721023C>T	ENST00000226444.3	-	3	379	c.267G>A	c.(265-267)atG>atA	p.M89I		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	89					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						CGTTACCATTCATGAGGTTTT	0.318000													11	41					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94746701	94746701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:94746701G>A	ENST00000399300.2	-	3	2151	c.1938C>T	c.(1936-1938)ctC>ctT	p.L646L	RBM12B_ENST00000520961.1_Intron|RBM12B_ENST00000517700.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	646							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CCTCCTCGGGGAGCTGCCTGA	0.647000													26	146					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34962775	34962775	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34962775G>A	ENST00000329357.5	+	1	1863	c.1827G>A	c.(1825-1827)aaG>aaA	p.K609K		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	609										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCATTGAAAAGCTGTTTGCCA	0.438000													89	70					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119106955	119106955	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119106955C>T	ENST00000328252.3	+	14	4114	c.3745C>T	c.(3745-3747)Cag>Tag	p.Q1249*	PAPPA_ENST00000534838.1_Nonsense_Mutation_p.Q287*	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1249	Sushi 1.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CTACGTGCTCCAGATACGGCG	0.582000													7	47					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120464920	120464920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120464920G>A	ENST00000256646.2	-	28	5371	c.5152C>T	c.(5152-5154)Cgc>Tgc	p.R1718C		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1718					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCATCTCGGCGAAGAGTGAAA	0.483000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				17	67					0	0	1	0	0
TBC1D22A	25771	broad.mit.edu	37	22	47193357	47193357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:47193357C>T	ENST00000337137.4	+	4	643	c.477C>T	c.(475-477)gcC>gcT	p.A159A	TBC1D22A_ENST00000406733.1_Silent_p.A112A|TBC1D22A_ENST00000355704.3_Intron|TBC1D22A_ENST00000380995.1_Silent_p.A112A|TBC1D22A_ENST00000407381.3_Intron	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	159						intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		CCAGCGATGCCGCCCCTCTGC	0.632000											OREG0026659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	128					0	0	1	0	0
HSF5	124535	broad.mit.edu	37	17	56557593	56557593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56557593G>A	ENST00000323777.3	-	2	695	c.586C>T	c.(586-588)Cgt>Tgt	p.R196C		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	196						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTATCTCGACGAAATGACCGG	0.433000													35	68					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142393656	142393656	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:142393656G>A	ENST00000378004.3	+	12	1474	c.1119G>A	c.(1117-1119)tcG>tcA	p.S373S	ARHGAP26_ENST00000274498.4_Silent_p.S373S	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	373					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding	p.S373S(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCTACAACTCGAACAAAGACA	0.428000													13	85					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159618524	159618524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159618524C>T	ENST00000297267.9	+	2	371	c.171C>T	c.(169-171)gtC>gtT	p.V57V	FNDC1_ENST00000340366.6_Silent_p.V57V	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	57	Fibronectin type-III 1.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCTGAAAGTCACGTGGGACC	0.453000													21	95					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558038	140558038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140558038G>A	ENST00000239444.2	+	1	668	c.423G>A	c.(421-423)gtG>gtA	p.V141V		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		141	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGTTGGTGAAAGTATCAG	0.413000													33	105					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48382030	48382030	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48382030C>T	ENST00000224600.4	-	4	3732	c.3619G>A	c.(3619-3621)Gaa>Aaa	p.E1207K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1207	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CCCACCCCTTCCCAGGAGCTG	0.642000													32	52					0	0	1	0	0
HK2	3099	broad.mit.edu	37	2	75115153	75115153	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:75115153C>T	ENST00000290573.2	+	16	2943	c.2343C>T	c.(2341-2343)atC>atT	p.I781I	HK2_ENST00000409174.1_Silent_p.I753I	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	781	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						CAAGGGGCATCTTTGAAACCA	0.512000													53	130					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71148051	71148051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71148051C>T	ENST00000283228.2	-	5	1110	c.658G>A	c.(658-660)Gac>Aac	p.D220N	PTPRR_ENST00000549308.1_5'UTR|PTPRR_ENST00000378778.1_Missense_Mutation_p.D14N|PTPRR_ENST00000440835.2_5'UTR|PTPRR_ENST00000342084.4_Missense_Mutation_p.D108N	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	220					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		CAGATTTTGTCCGCTTCATGC	0.358000													19	39					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83218214	83218214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83218214G>A	ENST00000562833.1	-	5	598	c.599C>T	c.(598-600)cCa>cTa	p.P200L	CPEB1_ENST00000568757.1_Silent_p.P390P|CPEB1_ENST00000563800.1_Silent_p.P492P|CPEB1_ENST00000568128.1_Silent_p.P465P|CPEB1_ENST00000562019.1_Silent_p.P470P|CPEB1_ENST00000423133.2_Silent_p.P390P|CPEB1_ENST00000398591.2_Silent_p.P395P|CPEB1_ENST00000398592.2_Silent_p.P239P|CPEB1_ENST00000450751.2_Silent_p.P390P|CPEB1_ENST00000261723.6_Silent_p.P468P|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000564522.1_Silent_p.P390P																							ACTTACCAATGGGATACTTGT	0.517000													17	55					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144942442	144942442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144942442C>T	ENST00000525985.1	-	2	5051	c.4980G>A	c.(4978-4980)caG>caA	p.Q1660Q				P58107	EPIPL_HUMAN	epiplakin 1	1660						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGAGGGAGATCTGCTGCCCGG	0.642000													34	74					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7976251	7976251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7976251G>A	ENST00000319144.4	-	15	2204	c.1944C>T	c.(1942-1944)ttC>ttT	p.F648F		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	648	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						GAATGTCCGGGAAGTGTCCCA	0.687000										Multiple Myeloma(8;0.094)			10	14					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56511246	56511246	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56511246C>T	ENST00000302957.3	-	1	41	c.42G>A	c.(40-42)gtG>gtA	p.V14V		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CTTCCATGTCCACGGAGGTGA	0.408000													32	94					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74904519	74904519	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74904519C>T	ENST00000289575.5	+	9	1727	c.1332C>T	c.(1330-1332)gcC>gcT	p.A444A	SLCO2B1_ENST00000428359.2_Silent_p.A422A|SLCO2B1_ENST00000454962.2_Silent_p.A217A|SLCO2B1_ENST00000341411.4_Silent_p.A217A|SLCO2B1_ENST00000531756.1_Silent_p.A189A|SLCO2B1_ENST00000532236.1_Silent_p.A328A|SLCO2B1_ENST00000525650.1_Silent_p.A300A	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	444					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	GATGCGGTGCCCTTTGCCTGC	0.632000													12	41					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11009471	11009471	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11009471G>A	ENST00000324288.8	+	14	3066	c.2933G>A	c.(2932-2934)cGg>cAg	p.R978Q	CIITA_ENST00000381835.5_Missense_Mutation_p.R394Q	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	978			Missing (in BLS2).		interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						AAACTGGTGCGGATCCTCACG	0.572000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								12	62					0	0	1	0	0
TRBV6-6	28601	broad.mit.edu	37	7	142162089	142162089	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142162089C>T	ENST00000390371.3	-	0	229																											AAATCAGCTTCAGCCCCATGC	0.478000													83	197					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064290	9064290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9064290G>A	ENST00000397910.4	-	3	23359	c.23156C>T	c.(23155-23157)tCa>tTa	p.S7719L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7721	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGAGAAGTGAAGTCACAGG	0.547000													34	70					0	0	1	0	0
CLDN17	26285	broad.mit.edu	37	21	31538872	31538872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31538872G>A	ENST00000286808.3	-	1	99	c.64C>T	c.(64-66)Ctt>Ttt	p.L22F		NM_012131.2	NP_036263.1	P56750	CLD17_HUMAN	claudin 17	22					calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(2)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	23						GTTGTGGCAAGAGTCCCCACC	0.483000													24	66					0	0	1	0	0
OCLN	100506658	broad.mit.edu	37	5	68800117	68800117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:68800117G>A	ENST00000355237.2	+	2	482	c.46G>A	c.(46-48)Gaa>Aaa	p.E16K	OCLN_ENST00000538151.1_5'UTR|OCLN_ENST00000396442.2_Missense_Mutation_p.E16K|OCLN_ENST00000380766.2_Missense_Mutation_p.E16K|OCLN_ENST00000542132.1_5'UTR	NM_002538.3	NP_002529.1	Q16625	OCLN_HUMAN	occludin	16					cellular component disassembly involved in apoptosis|protein complex assembly	integral to membrane|tight junction	protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|liver(1)|prostate(1)|skin(1)	6		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CAGGCCTGATGAATTGTAAGT	0.358000													12	24					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187192915	187192915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187192915C>T	ENST00000264692.4	+	3	541	c.208C>T	c.(208-210)Ccc>Tcc	p.P70S	F11_ENST00000492972.2_Missense_Mutation_p.P70S|F11_ENST00000403665.2_Missense_Mutation_p.P70S			P03951	FA11_HUMAN	coagulation factor XI	70	Apple 1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	ATCTGAGGATCCCACCCGATG	0.418000													28	97					0	0	1	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87329760	87329760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87329760G>A	ENST00000338056.3	+	4	724	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	RUNDC3B_ENST00000493037.1_Missense_Mutation_p.E88K|ABCB1_ENST00000265724.3_Intron|RUNDC3B_ENST00000394654.3_Missense_Mutation_p.E88K	NM_001134405.1|NM_138290.2	NP_001127877.1|NP_612147.1	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B	105	RUN.									breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(2)	26	Esophageal squamous(14;0.00164)					GTTTGGTTATGAAAGTCCTCG	0.343000													12	35					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141583073	141583073	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141583073G>A	ENST00000442267.2	-	10	1851	c.1777C>T	c.(1777-1779)Cga>Tga	p.R593*		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	593	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTGGGATTTCGAAAAGCATAA	0.398000													13	28					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168352575	168352575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:168352575C>T	ENST00000366806.2	+	30	4662	c.4520C>T	c.(4519-4521)tCg>tTg	p.S1507L	MLLT4_ENST00000447894.2_Missense_Mutation_p.S1507L|MLLT4_ENST00000351017.4_Missense_Mutation_p.S1514L|MLLT4_ENST00000392108.3_Missense_Mutation_p.S1507L|MLLT4_ENST00000392112.1_Missense_Mutation_p.S1490L|MLLT4_ENST00000400822.3_Missense_Mutation_p.S1506L|MLLT4_ENST00000344191.4_Missense_Mutation_p.S1507L			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	1507					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GAGCTTTCCTCGGGGGACAGT	0.592000			T	MLL	AL								16	35					0	0	1	0	0
RGS21	431704	broad.mit.edu	37	1	192321319	192321319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:192321319C>T	ENST00000417209.2	+	4	405	c.231C>T	c.(229-231)ttC>ttT	p.F77F		NM_001039152.3	NP_001034241.1	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	77	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			NS(1)|endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	15						ATTCTGAATTCATTGAAGCTG	0.388000													21	44					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47894564	47894564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47894564G>A	ENST00000289672.2	-	30	4825	c.4775C>T	c.(4774-4776)tCc>tTc	p.S1592F		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1592					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GGGGTTTTCGGAAAGCTCAGT	0.388000													32	94					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10721541	10721541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10721541C>T	ENST00000283025.2	-	7	1428	c.1357G>A	c.(1357-1359)Gag>Aag	p.E453K	TEKT5_ENST00000574923.1_5'UTR	NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	453					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule		p.E453K(1)		breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						ATGGCGAGCTCGTGCTCCAGC	0.637000													11	51					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196646781	196646781	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196646781G>A	ENST00000367429.4	+	5	843	c.603G>A	c.(601-603)gaG>gaA	p.E201E	CFH_ENST00000439155.2_Silent_p.E201E|CFH_ENST00000359637.2_Intron	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	201	Sushi 3.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GGAGTAAAGAGAAACCAAAGT	0.328000													30	144					0	0	1	0	0
MAP6	4135	broad.mit.edu	37	11	75319244	75319244	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75319244C>T	ENST00000434603.2	-	2	1093	c.1029G>A	c.(1027-1029)gaG>gaA	p.E343E	MAP6_ENST00000526740.1_Silent_p.E14E|MAP6_ENST00000304771.3_Silent_p.E343E	NM_207577.1	NP_997460.1	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6	343						Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	19	Ovarian(111;0.11)					GCTTGCTGGCCTCTCCTTTGA	0.498000													10	99					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50826513	50826513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50826513G>A	ENST00000376959.2	-	2	1860	c.1697C>T	c.(1696-1698)cCc>cTc	p.P566L	KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000477616.1_Missense_Mutation_p.P566L|KCNC3_ENST00000391818.2_Intron			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	566					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CGGTTGCGGGGGCCGGGGGAT	0.657000													9	13					0	0	1	0	0
KCNJ11	3767	broad.mit.edu	37	11	17408842	17408842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17408842G>A	ENST00000339994.4	-	1	1364	c.797C>T	c.(796-798)cCa>cTa	p.P266L	KCNJ11_ENST00000528731.1_Missense_Mutation_p.P179L	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	179						integral to membrane	ATP-activated inward rectifier potassium channel activity			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		GTCGTAGAGTGGGCTGTTGGC	0.607000											OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	76					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75150111	75150111	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75150111G>A	ENST00000356357.4	-	5	884	c.369C>T	c.(367-369)tcC>tcT	p.S123S	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		TTACTACGTTGGAATTGGGCT	0.488000													32	146					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39281897	39281897	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:39281897G>A	ENST00000426016.1	-	6	664	c.578C>T	c.(577-579)cCt>cTt	p.P193L	SOS1_ENST00000395038.2_Missense_Mutation_p.P193L|SOS1_ENST00000428721.2_Missense_Mutation_p.P136L|SOS1_ENST00000402219.2_Missense_Mutation_p.P193L			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	193					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				TGAGGTGGAAGGCTCTTCGTC	0.279000									Noonan syndrome				44	137					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086197	92086197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92086197G>A	ENST00000298047.6	+	1	936	c.919G>A	c.(919-921)Gat>Aat	p.D307N	FAT3_ENST00000541502.1_Missense_Mutation_p.D307N|FAT3_ENST00000409404.2_Missense_Mutation_p.D307N|FAT3_ENST00000525166.1_Missense_Mutation_p.D157N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	307	Cadherin 3.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGTGGCTGGGGATCCTTTAGA	0.448000										TCGA Ovarian(4;0.039)			14	37					0	0	1	0	0
CRYGA	1418	broad.mit.edu	37	2	209025752	209025752	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:209025752G>A	ENST00000304502.4	-	3	320	c.301C>T	c.(301-303)Ctt>Ttt	p.L101F		NM_014617.3	NP_055432.2			crystallin, gamma A											endometrium(1)|kidney(3)|large_intestine(1)|lung(7)	12				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		TCAGACATAAGGCCTCGGTAG	0.498000													30	55					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697549	6697549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6697549G>A	ENST00000245907.6	-	21	2694	c.2602C>T	c.(2602-2604)Cac>Tac	p.H868Y		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	868					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GCTGGATTGTGGAGTAGTTCC	0.592000													8	44					0	0	1	0	0
IGSF8	93185	broad.mit.edu	37	1	160062981	160062981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160062981G>A	ENST00000368086.1	-	4	1261	c.1045C>T	c.(1045-1047)Cct>Tct	p.P349S	IGSF8_ENST00000314485.7_Missense_Mutation_p.P349S			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	349	Ig-like C2-type 3.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCCCCCGCAGGTGCCATCTCC	0.662000													10	28					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921209	24921209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24921209C>T	ENST00000329468.2	+	1	669	c.195C>T	c.(193-195)ttC>ttT	p.F65F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1									p.F65F(1)									CCAGCATCTTCGTCGCCCCTA	0.721000													11	35					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416016	178416016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178416016C>T	ENST00000231188.5	-	6	1452	c.1274G>A	c.(1273-1275)gGg>gAg	p.G425E	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Missense_Mutation_p.G425E	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	425					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GCCTGTGTGCCCAGGGCAGAG	0.627000													6	29					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542887	14542887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14542887C>T	ENST00000358970.5	-	1	258	c.259G>A	c.(259-261)Gac>Aac	p.D87N	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	87										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGGAGTTGTCATGGTCTCCA	0.592000													72	320					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15661511	15661511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15661511C>T	ENST00000281171.4	+	7	1604	c.1274C>T	c.(1273-1275)tCa>tTa	p.S425L	PTPRO_ENST00000543886.1_Missense_Mutation_p.S425L|PTPRO_ENST00000348962.2_Missense_Mutation_p.S425L	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	425						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				GCAGGTCCTTCAGGAGAGTGG	0.458000													4	24					0	0	1	0	0
DDI2	84301	broad.mit.edu	37	1	15978206	15978206	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15978206C>T	ENST00000480945.1	+	8	1170	c.999C>T	c.(997-999)tcC>tcT	p.S333S		NM_032341.4	NP_115717.3	Q5TDH0	DDI2_HUMAN	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	333					proteolysis		aspartic-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|stomach(1)	17		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CCAAGTGTTCCATCGACCTGA	0.448000													16	52					0	0	1	0	0
OR1I1	126370	broad.mit.edu	37	19	15198013	15198013	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15198013T>A	ENST00000209540.2	+	1	223	c.137T>A	c.(136-138)aTc>aAc	p.I46N		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						GCCCTCATTATCCTGGCCATC	0.512000													28	52					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25308673	25308673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25308673G>A	ENST00000400358.4	+	22	2939	c.2882G>A	c.(2881-2883)gGa>gAa	p.G961E	SGSM1_ENST00000400359.4_Missense_Mutation_p.G1016E	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	1016	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TTCCCCCACGGAGGCGCCATG	0.507000													4	39					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28650782	28650782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28650782C>T	ENST00000280904.6	-	14	2603	c.2160G>A	c.(2158-2160)ggG>ggA	p.G720G	DSC2_ENST00000251081.6_Silent_p.G720G	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	720					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GTTTAGACGTCCCAGAAGCCC	0.388000													19	86					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108487953	108487953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108487953G>A	ENST00000408999.3	+	20	3570	c.3493G>A	c.(3493-3495)Gag>Aag	p.E1165K	RGPD4_ENST00000354986.4_Missense_Mutation_p.E1165K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1165	RanBD1 1.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						GCAGAAATTTGAGGAATGCCA	0.433000													22	203					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74658705	74658705	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74658705G>A	ENST00000334011.5	+	2	563	c.345G>A	c.(343-345)tgG>tgA	p.W115*		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	115						nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					GCTGTCTCTGGAACACCACGG	0.587000													19	51					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450542	158450542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158450542G>A	ENST00000368152.1	+	1	875	c.875G>A	c.(874-876)aGg>aAg	p.R292K	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					AACAAAGACAGGCTGGTGACG	0.458000													19	61					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54798615	54798615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54798615C>T	ENST00000293379.4	-	13	1550	c.1289G>A	c.(1288-1290)gGg>gAg	p.G430E	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	430					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						TCCTGGGCCCCCAGGAAATAC	0.617000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	36					0	0	1	0	0
IFNA7	3444	broad.mit.edu	37	9	21201733	21201733	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21201733C>T	ENST00000239347.3	-	1	471	c.432G>A	c.(430-432)agG>agA	p.R144R		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	144					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGAAGTATTTCCTCACAGCCA	0.448000													47	337					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7875820	7875820	+	Missense_Mutation	SNP	G	G	A	rs139675589		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:7875820G>A	ENST00000378789.3	-	5	824	c.773C>T	c.(772-774)tCg>tTg	p.S258L		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	258	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CCCATGATTCGACACCAAGAT	0.483000													33	71					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	132110663	132110663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132110663G>A	ENST00000404460.1	+	7	548	c.494G>A	c.(493-495)cGa>cAa	p.R165Q	PLEKHB2_ENST00000303908.3_Missense_Mutation_p.R165Q			Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	0						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		CTCCCAACGCGATGTTTTTTT	0.448000													13	26					0	0	1	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253688	32253688	+	Silent	SNP	G	G	A	rs143748718		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32253688G>A	ENST00000332378.4	-	1	186	c.156C>T	c.(154-156)ctC>ctT	p.L52L		NM_175858.2	NP_787054.1	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	52						keratin filament	structural molecule activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|pancreas(1)	18						AGTGGTCCAGGAGCCAAGAGC	0.572000													16	53					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99319926	99319926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99319926C>T	ENST00000336374.2	-	3	213	c.211G>A	c.(211-213)Gtc>Atc	p.V71I		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	71			V -> A (in dbSNP:rs45580339).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					CACCCCCAGACTTTTCTATAC	0.393000													8	87					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021437	132021437	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132021437C>T	ENST00000356920.5	+	15	2503	c.2409C>T	c.(2407-2409)atC>atT	p.I803I	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	803	Actin-like.						ATP binding										AGCACCCCATCCTGCTGACCG	0.587000													66	161					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115371995	115371995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115371995C>T	ENST00000369358.4	-	30	3764	c.3520G>A	c.(3520-3522)Gag>Aag	p.E1174K	NRAP_ENST00000360478.3_Missense_Mutation_p.E1131K|NRAP_ENST00000369360.3_Missense_Mutation_p.E1139K|NRAP_ENST00000359988.3_Missense_Mutation_p.E1166K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1166						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CTCCTTACCTCACTCTGCAAT	0.542000													25	61					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167659342	167659342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167659342G>A	ENST00000367854.3	+	4	586	c.255G>A	c.(253-255)ctG>ctA	p.L85L	RCSD1_ENST00000537350.1_Silent_p.L55L	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	85								p.L85L(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					GCTCGCCTCTGATTGAGAAGC	0.423000													20	81					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103124179	103124179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103124179C>T	ENST00000428762.1	-	62	10261	c.10102G>A	c.(10102-10104)Ggg>Agg	p.G3368R	CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000343529.5_Missense_Mutation_p.G3368R|RELN_ENST00000473945.1_5'UTR|RELN_ENST00000424685.2_Missense_Mutation_p.G3368R	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3368					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGGTGATCCCGTTGTTGACG	0.557000													32	130					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215896555	215896555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215896555G>A	ENST00000272895.7	-	9	1270	c.1051C>T	c.(1051-1053)Ctg>Ttg	p.L351L	AC072062.3_ENST00000437897.3_RNA|ABCA12_ENST00000389661.4_Silent_p.L33L	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	351					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGTGCAGCCAGACTGCTTGGA	0.328000													49	122					0	0	1	0	0
ACTL7A	10881	broad.mit.edu	37	9	111624631	111624631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111624631G>A	ENST00000333999.3	+	1	29	c.29G>A	c.(28-30)gGg>gAg	p.G10E		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	10						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GCAATCATGGGGGATGGGCCC	0.597000													22	63					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37710234	37710234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37710234C>T	ENST00000400485.1	+	4	526	c.450C>T	c.(448-450)ttC>ttT	p.F150F	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	150					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						TAGTGGCATTCAACAAGCACC	0.378000													53	116					0	0	1	0	0
RNF10	9921	broad.mit.edu	37	12	121002954	121002954	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121002954C>T	ENST00000325954.4	+	11	2206	c.1745C>T	c.(1744-1746)cCt>cTt	p.P582L	RNF10_ENST00000413266.2_Missense_Mutation_p.P587L	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	582					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTTTGCAACCTCCTGTGGTC	0.478000													16	128					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151970819	151970819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151970819G>A	ENST00000355193.2	-	7	1201	c.983C>T	c.(982-984)cCa>cTa	p.P328L	KMT2C_ENST00000262189.6_Missense_Mutation_p.P328L					lysine (K)-specific methyltransferase 2C																		AATGTGTTCTGGACAAAGCAG	0.378000													18	381					0	0	1	0	0
KRT85	3891	broad.mit.edu	37	12	52754805	52754805	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52754805G>A	ENST00000257901.3	-	9	1431	c.1356C>T	c.(1354-1356)gtC>gtT	p.V452V	KRT85_ENST00000544265.1_Silent_p.V240V	NM_002283.3	NP_002274.1	P78386	KRT85_HUMAN	keratin 85	452	Tail.				epidermis development	keratin filament	protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(7)|liver(1)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	36	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CCCCACAGGAGACTCCACCAC	0.652000													4	10					0	0	1	0	0
TRAJ36	28719	broad.mit.edu	37	14	22974135	22974135	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22974135G>A	ENST00000390501.1	+	0	40																											GGACTGGAACGAGACTCACCG	0.418000													23	55					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161152234	161152234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161152234C>T	ENST00000308192.9	+	11	1471	c.1408C>T	c.(1408-1410)Ctt>Ttt	p.L470F		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	470					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGTTGTCCTGCTTCCAGATGT	0.498000													11	54					0	0	1	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672818	141672818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141672818C>T	ENST00000547270.1	-	1	755	c.672G>A	c.(670-672)atG>atA	p.M224I		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	224					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					TCATTGTCCTCATGTGCCTTC	0.468000													24	62					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202702705	202702705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202702705G>A	ENST00000367265.3	-	23	4897	c.3733C>T	c.(3733-3735)Cgc>Tgc	p.R1245C	KDM5B_ENST00000367264.2_Missense_Mutation_p.R1281C	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1245					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding	p.R1245C(1)		breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TCAGGAAGGCGAACTCGGATA	0.512000													44	90					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192395	132192395	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:132192395G>A	ENST00000359827.3	-	2	2020	c.1058C>T	c.(1057-1059)tCg>tTg	p.S353L	PLXNA4_ENST00000423507.2_Missense_Mutation_p.S353L|PLXNA4_ENST00000378539.5_Missense_Mutation_p.S353L|PLXNA4_ENST00000321063.4_Missense_Mutation_p.S353L			Q9HCM2	PLXA4_HUMAN	plexin A4	353	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCACAGGGCCGACTCATCCAG	0.572000													19	72					0	0	1	0	0
CPNE9	151835	broad.mit.edu	37	3	9756994	9756994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9756994C>T	ENST00000383832.3	+	12	904	c.714C>T	c.(712-714)ttC>ttT	p.F238F	CPNE9_ENST00000383831.3_Silent_p.F238F	NM_153635.2	NP_705899.2	Q8IYJ1	CPNE9_HUMAN	copine family member IX	238	C2 2.									breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16	Medulloblastoma(99;0.227)					TTGGTGAGTTCACCACCAGCT	0.567000													14	71					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116285273	116285273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116285273G>A	ENST00000374140.2	+	18	2031	c.1822G>A	c.(1822-1824)Gac>Aac	p.D608N	RGS3_ENST00000343817.5_Missense_Mutation_p.D327N|RGS3_ENST00000350696.5_Missense_Mutation_p.D608N|RGS3_ENST00000317613.6_Missense_Mutation_p.D496N|RGS3_ENST00000394646.3_Missense_Mutation_p.D327N|RGS3_ENST00000374136.1_Missense_Mutation_p.D234N	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	608					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						TGGCCGCTGCGACGTCCTGAG	0.582000													12	118					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103698508	103698508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:103698508C>T	ENST00000245312.3	-	6	1618	c.1022G>A	c.(1021-1023)gGa>gAa	p.G341E		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	341					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TTGAAATCCTCCATTTGCCTT	0.363000													30	80					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	31062105	31062105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31062105C>T	ENST00000399914.1	-	3	1008	c.487G>A	c.(487-489)Gat>Aat	p.D163N	GRIK1_ENST00000389125.3_Missense_Mutation_p.D163N|GRIK1_ENST00000309434.7_Missense_Mutation_p.D163N|GRIK1_ENST00000327783.4_Missense_Mutation_p.D163N|GRIK1_ENST00000535441.1_Missense_Mutation_p.D163N|GRIK1_ENST00000389124.2_Missense_Mutation_p.D163N|GRIK1_ENST00000399907.1_Missense_Mutation_p.D163N|GRIK1_ENST00000399909.1_Missense_Mutation_p.D163N|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000399913.1_Missense_Mutation_p.D163N			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	163					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AGGACCAGATCCAGGATCGCC	0.488000													29	221					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69682029	69682029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69682029G>A	ENST00000265403.7	+	1	319	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	UGT2B10_ENST00000458688.2_Missense_Mutation_p.E98K	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	98					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						GAGATTGTCAGAAATTCAAAA	0.313000													37	94					0	0	1	0	0
IL12B	3593	broad.mit.edu	37	5	158747383	158747383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:158747383C>T	ENST00000231228.2	-	5	1083	c.628G>A	c.(628-630)Gtc>Atc	p.V210I		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	210					cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCACCATGACCTCAATGGGC	0.502000													11	136					0	0	1	0	0
RECK	8434	broad.mit.edu	37	9	36122898	36122898	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:36122898C>T	ENST00000377966.3	+	21	3338	c.2772C>T	c.(2770-2772)gtC>gtT	p.V924V		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	924						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CGTCCCATGTCCCTCTCTCTG	0.557000													35	126					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50683749	50683749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:50683749C>T	ENST00000442544.2	+	8	1901	c.1285C>T	c.(1285-1287)Cct>Tct	p.P429S	DCC_ENST00000580146.1_3'UTR|DCC_ENST00000412726.1_Missense_Mutation_p.P277S|DCC_ENST00000581580.1_Missense_Mutation_p.P84S	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	429	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CAGTGTCCTCCCTTCGGCTCC	0.537000													82	180					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99655718	99655718	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99655718C>T	ENST00000370597.3	-	10	1596	c.1241G>A	c.(1240-1242)gGa>gAa	p.G414E	CRTAC1_ENST00000370591.2_Missense_Mutation_p.G414E|CRTAC1_ENST00000298819.4_Missense_Mutation_p.G414E	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	414						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CATCCCGTCTCCGTCGAAGTC	0.582000													6	68					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717466	222717466	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:222717466G>A	ENST00000343410.6	-	2	445	c.387C>T	c.(385-387)ctC>ctT	p.L129L		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	129					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		AGAGGCCCGGGAGATTCCGGA	0.577000													65	158					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152554067	152554067	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152554067G>A	ENST00000427231.2	-	14	1450	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F	NEB_ENST00000409198.1_Silent_p.F416F|NEB_ENST00000397345.3_Silent_p.F416F|NEB_ENST00000604864.1_Silent_p.F416F|NEB_ENST00000172853.10_Silent_p.F416F|NEB_ENST00000603639.1_Silent_p.F416F	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	416					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATCACTACTGAAGTTCTGCA	0.343000													9	97					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24491771	24491771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:24491771G>A	ENST00000264463.4	-	11	2297	c.1790C>T	c.(1789-1791)tCc>tTc	p.S597F	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	597	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCACTGCAGGATTGCATGTT	0.527000										HNSCC(23;0.051)			34	83					0	0	1	0	0
TNFSF4	7292	broad.mit.edu	37	1	173176258	173176258	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173176258C>T	ENST00000281834.3	-	1	194	c.58G>A	c.(58-60)Gag>Aag	p.E20K		NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	20					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						TTGTTCCTCTCGAATCTTGGC	0.512000													23	70					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189996	124189996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124189996C>T	ENST00000357438.2	-	1	188	c.98G>A	c.(97-99)gGa>gAa	p.G33E		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		CACATATATTCCAAGGAACAG	0.463000													33	113					0	0	1	0	0
LCN1	3933	broad.mit.edu	37	9	138415807	138415807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138415807G>A	ENST00000263598.2	+	4	434	c.374G>A	c.(373-375)gGg>gAg	p.G125E	LCN1_ENST00000371781.3_Missense_Mutation_p.G125E	NM_001252617.1|NM_001252618.1|NM_001252619.1|NM_002297.3	NP_001239546.1|NP_001239547.1|NP_001239548.1|NP_002288.1	P31025	LCN1_HUMAN	lipocalin 1	125					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)	13		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		GAGCTGCACGGGAAGCCGGTC	0.637000													11	41					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10603749	10603749	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:10603749C>T	ENST00000334534.5	+	8	1129	c.949C>T	c.(949-951)Cga>Tga	p.R317*		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		TGGAAGTGATCGATTAGTCCC	0.458000													33	125					0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242139	60242139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:60242139C>T	ENST00000269499.5	+	13	3243	c.2825C>T	c.(2824-2826)tCt>tTt	p.S942F	ZCCHC2_ENST00000586834.1_Missense_Mutation_p.S621F	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	942					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						GCAGCAACTTCTCCCCAGCCA	0.652000													8	106					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37506753	37506753	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37506753G>A	ENST00000374660.1	+	39	3502	c.3403G>A	c.(3403-3405)Gct>Act	p.A1135T	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.A1016T|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.A1016T			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1110						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ACTTGAACAGGCTCTCAGAAT	0.289000													11	54					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98460836	98460836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98460836G>A	ENST00000450876.1	-	2	1336	c.21C>T	c.(19-21)tcC>tcT	p.S7S	TMEM130_ENST00000546258.1_Silent_p.S72S|TMEM130_ENST00000416379.2_Silent_p.S91S|TMEM130_ENST00000345589.4_Intron|TMEM130_ENST00000339375.4_Silent_p.S91S			Q8N3G9	TM130_HUMAN	transmembrane protein 130	91						Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CACGGATGGTGGAGCTGAGAC	0.657000													8	63					0	0	1	0	0
NT5C3B	115024	broad.mit.edu	37	17	39985108	39985108	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39985108G>A	ENST00000269534.8	-	7	578	c.477C>T	c.(475-477)atC>atT	p.I159I	NT5C3B_ENST00000521789.1_Silent_p.I134I|NT5C3B_ENST00000435506.2_Silent_p.I167I	NM_052935.4	NP_443167.4			5'-nucleotidase, cytosolic IIIB																		TCATCTGTCGGATAATTTCTT	0.438000													34	59					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233353659	233353659	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233353659C>A	ENST00000258229.8	-	12	2911	c.2677G>T	c.(2677-2679)Gcc>Tcc	p.A893S	PCNXL2_ENST00000488780.2_Missense_Mutation_p.A26S|PCNXL2_ENST00000430153.1_Missense_Mutation_p.A192S	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	893						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				ATTGGTGAGGCGGGGTCAGGC	0.433000													5	34					8.12818e-05	8.14103e-05	1	1	0
ENKUR	219670	broad.mit.edu	37	10	25273727	25273727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25273727C>T	ENST00000331161.4	-	5	921	c.702G>A	c.(700-702)atG>atA	p.M234I	ENKUR_ENST00000376363.1_Missense_Mutation_p.M234I	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	234						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						CTAGTTGTTTCATTTCTTCTT	0.348000													6	79					0	0	1	0	0
KCNN4	3783	broad.mit.edu	37	19	44278350	44278350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44278350G>A	ENST00000262888.3	-	3	1072	c.677C>T	c.(676-678)gCc>gTc	p.A226V		NM_002250.2	NP_002241.1	O15554	KCNN4_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	226					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	TCACCTCTCGGCCACGGACAG	0.677000											OREG0025535	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	17					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31540583	31540583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31540583C>T	ENST00000454783.1	+	2	322	c.64C>T	c.(64-66)Ctg>Ttg	p.L22L	LTA_ENST00000418386.2_Silent_p.L22L	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	22					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	CCTCCTCCTTCTGGGGCTGCT	0.622000													24	78					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55761363	55761363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55761363C>T	ENST00000278409.1	-	1	738	c.739G>A	c.(739-741)Gcc>Acc	p.A247T		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A247S(1)		endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					AGAATTATGGCTGTCAGGTGA	0.493000													12	81					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36570342	36570342	+	Silent	SNP	G	G	A	rs144959929	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36570342G>A	ENST00000273183.3	+	10	1275	c.975G>A	c.(973-975)ggG>ggA	p.G325G	STAC_ENST00000457375.2_Silent_p.G264G	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	325	SH3.				intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						CCTTTCAGGGGAAAATTCAAG	0.338000													13	28					0	0	1	0	0
RBFA	79863	broad.mit.edu	37	18	77797462	77797462	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:77797462G>A	ENST00000306735.5	+	3	472	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	RBFA_ENST00000262197.7_Missense_Mutation_p.E112K|RBFADN_ENST00000569722.1_Intron|RBFA_ENST00000586847.1_3'UTR	NM_024805.2	NP_079081.2	Q8N0V3	RBFA_HUMAN	ribosome binding factor A (putative)	112					rRNA processing	mitochondrion				endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|urinary_tract(1)	15						GTGTACCCCTGAAGTGAGTCA	0.552000													63	125					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77386640	77386640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77386640C>T	ENST00000451710.3	-	25	3752	c.3515G>A	c.(3514-3516)cGa>cAa	p.R1172Q	TRPM6_ENST00000376864.4_Missense_Mutation_p.R1172Q|TRPM6_ENST00000449912.2_Missense_Mutation_p.R1167Q|TRPM6_ENST00000360774.1_Missense_Mutation_p.R1172Q|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.R1167Q|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1172					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CACTCGGATTCGTTCCTCACA	0.368000													7	79					0	0	1	0	0
F13A1	2162	broad.mit.edu	37	6	6305701	6305701	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6305701C>T	ENST00000264870.3	-	3	467	c.202G>A	c.(202-204)Gac>Aac	p.D68N		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	68					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TCATACTTGTCAGTGTGGTGG	0.453000													14	62					0	0	1	0	0
MYEOV	26579	broad.mit.edu	37	11	69063826	69063826	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:69063826C>T	ENST00000535407.1	+	2	1378	c.735C>T	c.(733-735)ctC>ctT	p.L245L	MYEOV_ENST00000441339.2_Silent_p.L303L|MYEOV_ENST00000308946.3_Silent_p.L303L			Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	303										endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|urinary_tract(1)	24	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		accacctcctcctcctcctcc	0.577000													4	4					0	0	1	0	0
PDLIM5	10611	broad.mit.edu	37	4	95496819	95496819	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:95496819C>T	ENST00000317968.4	+	5	480	c.344C>T	c.(343-345)tCc>tTc	p.S115F	PDLIM5_ENST00000450793.1_Intron|PDLIM5_ENST00000542407.1_5'UTR|PDLIM5_ENST00000508216.1_Intron|PDLIM5_ENST00000514743.1_Intron|PDLIM5_ENST00000380180.3_Intron|PDLIM5_ENST00000538141.1_Intron|PDLIM5_ENST00000437932.1_Intron|PDLIM5_ENST00000318007.5_Intron	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	115					regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		CCTGCTGTGTCCAAAGTCACT	0.428000													52	139					0	0	1	0	0
FBXW12	285231	broad.mit.edu	37	3	48419867	48419867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48419867C>T	ENST00000296438.5	+	6	652	c.466C>T	c.(466-468)Cct>Tct	p.P156S	FBXW12_ENST00000445170.1_Missense_Mutation_p.P137S|FBXW12_ENST00000436231.1_Intron|FBXW12_ENST00000415155.1_Intron	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	156										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGTAACCCTCCCTCAGATGCA	0.507000													6	56					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192711529	192711529	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:192711529C>T	ENST00000304141.4	-	1	452	c.123G>A	c.(121-123)ggG>ggA	p.G41G	AC098617.1_ENST00000424116.2_RNA	NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	41						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CCTCTGTGTTCCCTAGGTTCA	0.607000													33	62					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25965265	25965265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:25965265G>A	ENST00000435504.4	-	13	4234	c.3941C>T	c.(3940-3942)cCg>cTg	p.P1314L	ASXL2_ENST00000272341.4_Missense_Mutation_p.P797L|ASXL2_ENST00000336112.4_Missense_Mutation_p.P1286L|ASXL2_ENST00000404843.1_Missense_Mutation_p.P797L			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	1314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATACAACTTCGGGGTTTGCAG	0.552000													6	9					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993181	28993181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28993181C>T	ENST00000359747.4	+	15	2832	c.2803C>T	c.(2803-2805)Cca>Tca	p.P935S	DSG4_ENST00000308128.4_Missense_Mutation_p.P916S|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	916					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TAATGCTGATCCATGTGTGCA	0.433000													68	144					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53662562	53662562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53662562C>T	ENST00000257934.4	+	2	103	c.12C>T	c.(10-12)ttC>ttT	p.F4F	ESPL1_ENST00000552462.1_Silent_p.F4F	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	4					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						TGAGGAGCTTCAAAAGAGTCA	0.532000													3	14					0	0	1	0	0
TMEM74	157753	broad.mit.edu	37	8	109797285	109797285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:109797285G>A	ENST00000297459.3	-	2	221	c.43C>T	c.(43-45)Ctc>Ttc	p.L15F	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	15					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			GCATCACAGAGGTCTGCCTGG	0.547000													14	53					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781494	128781494	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128781494G>A	ENST00000529694.1	+	2	702	c.326G>A	c.(325-327)tGg>tAg	p.W109*	KCNJ5_ENST00000338350.4_Nonsense_Mutation_p.W109*|KCNJ5_ENST00000533599.1_Nonsense_Mutation_p.W109*	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	109					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TTCATTTGGTGGCTCATTGCT	0.527000													32	71					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045064	87045064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87045064C>T	ENST00000370563.3	+	13	2192	c.2150C>T	c.(2149-2151)cCt>cTt	p.P717L	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	717						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CCGCCAAGACCTGAAATTGAT	0.438000													32	67					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800537	21800537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21800537C>T	ENST00000443632.2	+	2	1725	c.1353C>T	c.(1351-1353)ttC>ttT	p.F451F	HIC2_ENST00000407464.2_Silent_p.F451F|HIC2_ENST00000407598.2_Silent_p.F451F			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	451					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				CCAAGGGCTTCCCCAGCTCTG	0.622000													47	96					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1421334	1421334	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:1421334G>A	ENST00000381312.1	-	2	447	c.122C>T	c.(121-123)aCc>aTc	p.T41I		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	41					mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		AGCGAGGAAGGTTGACAATAT	0.433000													20	49					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17464325	17464325	+	Silent	SNP	C	C	T	rs61748766	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17464325C>T	ENST00000302539.4	-	10	1697	c.1572G>A	c.(1570-1572)acG>acA	p.T524T	ABCC8_ENST00000528202.1_5'UTR|ABCC8_ENST00000389817.3_Silent_p.T524T	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	524	ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TCCTGCGGGTCGTCTCCACCC	0.597000													20	58					0	0	1	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21743221	21743221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21743221G>A	ENST00000319481.3	-	28	2981	c.2775C>T	c.(2773-2775)ccC>ccT	p.P925P	OSBPL1A_ENST00000399443.3_Silent_p.P412P|OSBPL1A_ENST00000357041.4_Silent_p.P543P	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	925					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CTCCATTGTAGGGATTAGGAC	0.408000													25	65					0	0	1	0	0
FAM86B1	85002	broad.mit.edu	37	8	12044027	12044027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:12044027C>T	ENST00000448228.2	-	5	523	c.474G>A	c.(472-474)cgG>cgA	p.R158R	FAM86B1_ENST00000533513.1_3'UTR|FAM86B1_ENST00000321602.8_Intron|FAM86B1_ENST00000534520.1_Intron|FAM86B1_ENST00000533852.2_Silent_p.R192R	NM_001083537.1	NP_001077006.1	Q8N7N1	F86B1_HUMAN	family with sequence similarity 86, member B1	158										kidney(1)|prostate(1)|stomach(1)	3			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		GCTCGAGGACCCGGCTGTGAG	0.612000													12	44					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53630443	53630443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:53630443G>A	ENST00000342160.3	-	26	3219	c.2762C>T	c.(2761-2763)tCc>tTc	p.S921F	HUWE1_ENST00000218328.8_Missense_Mutation_p.S921F|HUWE1_ENST00000262854.6_Missense_Mutation_p.S921F			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	921					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTGGTTTACGGAGATGGAACG	0.418000													28	18					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158908993	158908993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158908993C>T	ENST00000368140.1	+	4	780	c.535C>T	c.(535-537)Ccc>Tcc	p.P179S	PYHIN1_ENST00000368138.3_Missense_Mutation_p.P170S|PYHIN1_ENST00000392254.2_Missense_Mutation_p.P179S|PYHIN1_ENST00000368135.4_Missense_Mutation_p.P179S|PYHIN1_ENST00000392252.3_Missense_Mutation_p.P170S	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	179					cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					TTCCCCACCTCCCCAGACCTC	0.522000													50	138					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9046410	9046410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9046410C>T	ENST00000397910.4	-	5	35424	c.35221G>A	c.(35221-35223)Gag>Aag	p.E11741K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11743	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCACCATCTCTGGTGCACCA	0.488000													35	95					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10440650	10440650	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10440650C>T	ENST00000245503.5	-	16	2181	c.1797G>A	c.(1795-1797)aaG>aaA	p.K599K	MYH2_ENST00000397183.2_Silent_p.K599K|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Silent_p.K599K	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	599	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GGTCCTTGTTCTTCTCCAGCC	0.527000													69	91					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138985	126138985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:126138985C>T	ENST00000299308.3	+	9	2974	c.2966C>T	c.(2965-2967)tCc>tTc	p.S989F	TMEM132B_ENST00000535886.1_Missense_Mutation_p.S501F	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	989						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AATGGCAGTTCCCAGAAGACT	0.453000													15	22					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55569674	55569674	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55569674G>A	ENST00000294383.6	-	42	4899	c.4900C>T	c.(4900-4902)Cga>Tga	p.R1634*	USP24_ENST00000407756.1_Nonsense_Mutation_p.R1474*	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1634					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						GCTGCCAATCGGCTATTCGCT	0.343000													7	6					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55419298	55419298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55419298G>A	ENST00000312422.2	+	1	919	c.919G>A	c.(919-921)Gag>Aag	p.E307K		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				TGTTTTCTTGGAGGCTAAAGG	0.363000													58	163					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569269	179569269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179569269G>A	ENST00000589042.1	-	105	30154	c.29930C>T	c.(29929-29931)cCa>cTa	p.P9977L	TTN_ENST00000342992.6_Missense_Mutation_p.P8733L|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.P9660L|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9660	Glu-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCGATGTGTGGACCACAAAC	0.373000													12	37					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875287	247875287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247875287G>A	ENST00000302084.2	-	1	818	c.771C>T	c.(769-771)ttC>ttT	p.F257F	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGACGTGAAGGAAAACTGTGG	0.527000													37	103					0	0	1	0	0
TESK1	7016	broad.mit.edu	37	9	35608894	35608894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35608894C>T	ENST00000336395.5	+	10	1286	c.1036C>T	c.(1036-1038)Ccc>Tcc	p.P346S	TESK1_ENST00000498522.1_3'UTR	NM_006285.2	NP_006276.2	Q15569	TESK1_HUMAN	testis-specific kinase 1	346					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	27			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TGCCACGCTTCCCAGGCCAGA	0.582000													41	112					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52031002	52031002	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52031002C>T	ENST00000346477.3	-	6	1207	c.1140_splice	c.e6+1	p.R380_splice	SIGLEC6_ENST00000359982.4_Intron|SIGLEC6_ENST00000391797.3_Intron|SIGLEC6_ENST00000474054.1_5'UTR|SIGLEC6_ENST00000343300.4_Intron|SIGLEC6_ENST00000436458.1_Splice_Site_p.R344_splice|SIGLEC6_ENST00000425629.3_Splice_Site_p.R396_splice	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	396					cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GTCACTCACCCTGGAGCCTGA	0.488000													35	164					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327197	150327197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150327197C>T	ENST00000328902.5	-	2	250	c.34G>A	c.(34-36)Gag>Aag	p.E12K	GIMAP6_ENST00000493969.1_Missense_Mutation_p.E12K	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	12							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGGGATTCTCCTGGGGAATT	0.423000													53	136					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57417739	57417739	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57417739C>T	ENST00000543257.1	-	6	1058	c.492G>A	c.(490-492)gtG>gtA	p.V164V	C8B_ENST00000371237.4_Silent_p.V216V|C8B_ENST00000535057.1_Silent_p.V154V	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	216	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGTAGCTTTCCACATTGTAGG	0.552000													48	97					0	0	1	0	0
SLC15A1	6564	broad.mit.edu	37	13	99378490	99378490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:99378490G>A	ENST00000376503.5	-	4	187	c.132C>T	c.(130-132)ttC>ttT	p.F44F		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	44					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CCCAGCTGATGAAATTTGTGA	0.522000													20	61					0	0	1	0	0
ST7	7982	broad.mit.edu	37	7	116862069	116862069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:116862069C>T	ENST00000265437.5	+	15	1805	c.1591C>T	c.(1591-1593)Ctc>Ttc	p.L531F	ST7_ENST00000393446.2_Missense_Mutation_p.L477F|ST7_ENST00000393449.1_Missense_Mutation_p.L526F|ST7_ENST00000393443.1_Missense_Mutation_p.L453F|ST7_ENST00000432298.1_Missense_Mutation_p.L485F|ST7_ENST00000323984.3_Missense_Mutation_p.L531F|ST7_ENST00000422922.1_Missense_Mutation_p.L462F|ST7_ENST00000393444.3_Missense_Mutation_p.L465F|ST7_ENST00000393451.3_Missense_Mutation_p.L508F|ST7_ENST00000393447.4_Missense_Mutation_p.L488F	NM_021908.2	NP_068708.1	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7	531						integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(1)	21	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CATGCTGGCCCTCCTGACACA	0.507000													27	92					0	0	1	0	0
DMRTC2	63946	broad.mit.edu	37	19	42354563	42354563	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42354563C>T	ENST00000596827.1	+	7	1025	c.939C>T	c.(937-939)ttC>ttT	p.F313F	DMRTC2_ENST00000269945.3_Intron			Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	275	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						AGCGGGGGTTCCCAGTCTGCT	0.617000													24	79					0	0	1	0	0
KISS1	3814	broad.mit.edu	37	1	204159666	204159666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204159666G>A	ENST00000367194.4	-	3	511	c.363C>T	c.(361-363)ttC>ttT	p.F121F		NM_002256.3	NP_002247.3	Q15726	KISS1_HUMAN	KiSS-1 metastasis-suppressor	121	Essential for receptor binding and receptor activation.				cytoskeleton organization	extracellular region	protein binding			large_intestine(1)|lung(1)|ovary(1)	3	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)	Breast(1374;9.42e-05)	KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.069)|Kidney(21;0.0934)|Epithelial(59;0.239)	Colorectal(1306;0.0129)		CCCGCTTGCCGAAGCGCAGGC	0.692000													9	8					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27660021	27660021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27660021C>T	ENST00000261588.4	+	6	524	c.505C>T	c.(505-507)Ctc>Ttc	p.L169F	KIAA0556_ENST00000567894.1_3'UTR	NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	169										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GGATGTGACTCTCCAGGCAAA	0.562000													10	42					0	0	1	0	0
GPR55	9290	broad.mit.edu	37	2	231775413	231775413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231775413G>A	ENST00000392040.1	-	2	457	c.265C>T	c.(265-267)Ccc>Tcc	p.P89S	GPR55_ENST00000392039.2_Missense_Mutation_p.P89S	NM_005683.3	NP_005674.2	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	89					activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			endometrium(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		GACGGGAAGGGGGACTGTACC	0.557000													24	56					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143747606	143747606	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143747606C>T	ENST00000408906.2	+	1	146	c.112C>T	c.(112-114)Ctg>Ttg	p.L38L		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CGTCTTCACCCTGCTGGGAAA	0.512000													53	100					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101609053	101609053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101609053C>T	ENST00000311812.2	-	10	942	c.792G>A	c.(790-792)cgG>cgA	p.R264R	SNX31_ENST00000428383.2_Silent_p.R165R	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	264					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			GCCGTACCTCCCGGGCCAGCT	0.512000													31	83					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3511920	3511920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3511920C>T	ENST00000356575.4	-	3	584	c.358G>A	c.(358-360)Gag>Aag	p.E120K		NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	120	EMI.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CAGCCCTCCTCGTCGGGCTGC	0.662000													21	57					0	0	1	0	0
PRSS35	167681	broad.mit.edu	37	6	84233940	84233940	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:84233940G>A	ENST00000536636.1	+	3	1125	c.780G>A	c.(778-780)ccG>ccA	p.P260P	PRSS35_ENST00000369700.3_Silent_p.P260P	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	260	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		CCCACATTCCGAAGGGCTGGG	0.537000													4	28					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73826224	73826224	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73826224C>T	ENST00000207549.4	-	30	3218	c.2839G>A	c.(2839-2841)Gac>Aac	p.D947N	UNC13D_ENST00000412096.2_Missense_Mutation_p.D947N	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	947	C2 2.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACAAAGGGGTCGCTGGAGCCT	0.637000									Familial Hemophagocytic Lymphohistiocytosis		OREG0024741	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	8					0	0	1	0	0
DDX55	57696	broad.mit.edu	37	12	124094582	124094582	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124094582C>T	ENST00000238146.4	+	7	698	c.648C>T	c.(646-648)ggC>ggT	p.G216G	DDX55_ENST00000538744.1_Silent_p.G216G	NM_020936.1	NP_065987.1	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	216	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TGAGAGCGGGCCTCCGGAACC	0.577000													24	52					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24433686	24433686	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24433686C>T	ENST00000330966.7	-	4	444	c.282G>A	c.(280-282)gaG>gaA	p.E94E	MYOM3_ENST00000374434.3_Silent_p.E93E|MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Silent_p.E93E			Q5VTT5	MYOM3_HUMAN	myomesin 3	93										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCTCCTCCAGCTCCACGGCAG	0.687000													4	14					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158257668	158257668	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:158257668T>A	ENST00000296526.7	+	11	1938	c.1613T>A	c.(1612-1614)tTt>tAt	p.F538Y	GRIA2_ENST00000449365.1_Missense_Mutation_p.F491Y|GRIA2_ENST00000264426.9_Missense_Mutation_p.F538Y|GRIA2_ENST00000393815.2_Missense_Mutation_p.F491Y|GRIA2_ENST00000507898.1_Missense_Mutation_p.F491Y	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	538					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GTGTTTTCCTTTCTTGATCCT	0.448000													86	232					0	0	1	0	0
TMCO4	255104	broad.mit.edu	37	1	20107104	20107104	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20107104G>A	ENST00000294543.6	-	4	389	c.148C>T	c.(148-150)Ctg>Ttg	p.L50L	TMCO4_ENST00000375122.2_Silent_p.L50L|TMCO4_ENST00000375127.1_Silent_p.L50L	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	50						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AACTGGGACAGGGAGATGCCA	0.592000													11	37					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17294426	17294426	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:17294426C>T	ENST00000261381.6	-	4	1083	c.999G>A	c.(997-999)gtG>gtA	p.V333V		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	333					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGCCGTGGACCACCAGGACAA	0.562000													59	146					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120512162	120512162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120512162G>A	ENST00000256646.2	-	6	1299	c.1080C>T	c.(1078-1080)ttC>ttT	p.F360F		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	360	EGF-like 9; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACATGCAAGAGAAGGAGGCCA	0.562000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				4	37					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239016599	239016599	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239016599G>A	ENST00000343063.3	+	4	1103	c.840G>A	c.(838-840)gaG>gaA	p.E280E	ESPNL_ENST00000409169.1_Silent_p.E280E	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	280										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		ACGCAGCAGAGAACGGGCAGA	0.642000													9	32					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150693611	150693611	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150693611C>T	ENST00000297494.3	+	4	747	c.390C>T	c.(388-390)ttC>ttT	p.F130F	NOS3_ENST00000461406.1_Intron|NOS3_ENST00000467517.1_Silent_p.F130F|NOS3_ENST00000484524.1_Silent_p.F130F	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	130	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCCGGGACTTCATCAACCAGT	0.652000													13	23					0	0	1	0	0
RP11-85G18.6	0	broad.mit.edu	37	10	27535148	27535148	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27535148C>T	ENST00000574842.1	+	0	255																											GTTATTTACTCTTGTGGCACT	0.473000													15	23					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49825033	49825033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:49825033C>T	ENST00000451037.2	-	4	1365	c.425G>A	c.(424-426)gGg>gAg	p.G142E	CA10_ENST00000570565.1_Missense_Mutation_p.G67E|CA10_ENST00000571918.1_5'UTR|CA10_ENST00000442502.2_Missense_Mutation_p.G142E|CA10_ENST00000285273.4_Missense_Mutation_p.G142E|CA10_ENST00000340813.6_Missense_Mutation_p.G148E	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	142					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTGCTCCGACCCTTGGCTGTC	0.512000													57	131					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124358351	124358351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124358351G>A	ENST00000368909.3	+	26	3124	c.3018G>A	c.(3016-3018)gtG>gtA	p.V1006V	DMBT1_ENST00000330163.4_Silent_p.V507V|DMBT1_ENST00000368955.3_Silent_p.V996V|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Silent_p.V507V|DMBT1_ENST00000344338.3_Silent_p.V996V|DMBT1_ENST00000338354.3_Silent_p.V1006V	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1006	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AGGGCCGAGTGGAGGTCCTAT	0.572000													141	450					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58118247	58118247	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58118247C>T	ENST00000332854.6	+	3	1574	c.1354C>T	c.(1354-1356)Cga>Tga	p.R452*	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGGCCTCTTTCGACACAGAAG	0.423000													37	126					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58074568	58074568	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58074568C>T	ENST00000219271.3	+	5	1661	c.876C>T	c.(874-876)ccC>ccT	p.P292P		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	292					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						TCAAGCTGCCCGAGGACGATC	0.627000													28	63					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106960963	106960963	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106960963G>A	ENST00000369701.3	+	16	2440	c.2213G>A	c.(2212-2214)gGa>gAa	p.G738E	SORCS3_ENST00000369699.4_Missense_Mutation_p.G24E	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	738						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GACCACTCAGGATCAGTGGTC	0.493000													22	103					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367424	234367424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:234367424C>T	ENST00000366618.3	+	3	690	c.545C>T	c.(544-546)cCg>cTg	p.P182L	SLC35F3_ENST00000366617.3_Missense_Mutation_p.P113L	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	113					transport	integral to membrane		p.P182Q(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TTATTCTTCCCGTTGTACTAC	0.592000													10	195					0	0	1	0	0
TTTY11	83866	broad.mit.edu	37	Y	8657192	8657192	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:8657192C>T	ENST00000253470.4	-	0	272					NR_001548.2																						TGCCAATGTTCTCATGACCAC	0.433000													10	13					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125877456	125877456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125877456G>A	ENST00000393434.2	-	3	503	c.154C>T	c.(154-156)Ccg>Tcg	p.P52S	ALDH1L1_ENST00000273450.3_Missense_Mutation_p.P62S|ALDH1L1_ENST00000393431.2_Missense_Mutation_p.P52S|ALDH1L1_ENST00000472186.1_Missense_Mutation_p.P52S|ALDH1L1_ENST00000452905.2_Missense_Mutation_p.P52S|ALDH1L1_ENST00000455064.2_Intron	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	52	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TTGAATACCGGCACTCCATCC	0.582000													19	107					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140221126	140221126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140221126C>T	ENST00000531613.1	+	1	220	c.220C>T	c.(220-222)Ctt>Ttt	p.L74F	PCDHA8_ENST00000378123.3_Missense_Mutation_p.L74F|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACCGGGACCTTCTGGAGGT	0.642000													24	220					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31215756	31215756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31215756C>T	ENST00000349752.5	-	2	886	c.247G>A	c.(247-249)Gag>Aag	p.E83K	GALNT14_ENST00000420311.2_Missense_Mutation_p.E48K|GALNT14_ENST00000406653.1_Missense_Mutation_p.E63K|GALNT14_ENST00000356174.3_Missense_Mutation_p.E83K|GALNT14_ENST00000324589.5_Intron	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	83						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					CGCTCACTCTCCCGCTGGTTG	0.562000													31	73					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100581155	100581155	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100581155C>T	ENST00000471714.1	-	14	1415	c.1306_splice	c.e14+1	p.A436_splice	ABI3BP_ENST00000495063.1_Splice_Site_p.A436_splice|ABI3BP_ENST00000284322.5_Splice_Site_p.A387_splice			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	409	Pro-rich.					extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						ATTTAATTACCAGTTTGAGGC	0.299000													4	17					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152060506	152060506	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152060506C>T	ENST00000368806.1	-	2	178	c.114G>A	c.(112-114)caG>caA	p.Q38Q		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	38							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CAAACTCGCCCTGGATGAGTT	0.443000													50	194					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126371800	126371800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126371800G>A	ENST00000394329.3	+	9	9642	c.9629G>A	c.(9628-9630)gGa>gAa	p.G3210E	FAT4_ENST00000335110.5_Missense_Mutation_p.G1508E	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3210	Cadherin 31.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCCCCAAGTGGAACAACAGTT	0.408000													44	89					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120906771	120906771	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120906771C>T	ENST00000310396.5	+	20	3009	c.2542C>T	c.(2542-2544)Cta>Tta	p.L848L		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		ATCACGTCCCCTAGAGAATAC	0.403000													29	97					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14564608	14564608	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14564608G>A	ENST00000273083.3	-	0	556							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CAAGAAGCAGGAATCATCCAC	0.587000													22	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179466465	179466465	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179466465C>T	ENST00000589042.1	-	286	55576	c.55352G>A	c.(55351-55353)cGa>cAa	p.R18451Q	TTN_ENST00000342992.6_Missense_Mutation_p.R15883Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R9386Q|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R9578Q|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R9511Q|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R16810Q|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16810	Ig-like 106.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTATGAGATCGTTTACACTC	0.363000													23	80					0	0	1	0	0
SCN3B	55800	broad.mit.edu	37	11	123513287	123513287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123513287G>A	ENST00000392770.2	-	3	1114	c.312C>T	c.(310-312)tcC>tcT	p.S104S	SCN3B_ENST00000530277.1_Silent_p.S104S|SCN3B_ENST00000299333.3_Silent_p.S104S	NM_018400.3	NP_060870.1	Q9NY72	SCN3B_HUMAN	sodium channel, voltage-gated, type III, beta subunit	104	Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|skin(2)	26		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		GCACAGTGATGGACACGTCCT	0.567000													23	65					0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24845205	24845205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24845205G>A	ENST00000413692.2	+	9	2287	c.2143G>A	c.(2143-2145)Gag>Aag	p.E715K	NFATC4_ENST00000553879.1_Missense_Mutation_p.E582K|NFATC4_ENST00000555167.1_Missense_Mutation_p.E187K|NFATC4_ENST00000557767.1_5'UTR|NFATC4_ENST00000555590.1_Missense_Mutation_p.E665K|NFATC4_ENST00000555393.1_5'UTR|NFATC4_ENST00000555802.1_5'UTR|NFATC4_ENST00000554966.1_Missense_Mutation_p.E665K|NFATC4_ENST00000555453.1_Missense_Mutation_p.E640K|NFATC4_ENST00000553469.1_Missense_Mutation_p.E684K|NFATC4_ENST00000556759.1_Missense_Mutation_p.E187K|NFATC4_ENST00000557451.1_Missense_Mutation_p.E582K|NFATC4_ENST00000553708.1_Missense_Mutation_p.E652K|NFATC4_ENST00000556169.1_Missense_Mutation_p.E640K|NFATC4_ENST00000424781.2_Missense_Mutation_p.E665K|NFATC4_ENST00000554591.1_Missense_Mutation_p.E715K|NFATC4_ENST00000556279.1_Missense_Mutation_p.E684K|NFATC4_ENST00000422617.3_Missense_Mutation_p.E640K|NFATC4_ENST00000554050.1_Missense_Mutation_p.E652K|NFATC4_ENST00000554344.1_Missense_Mutation_p.E582K|NFATC4_ENST00000539237.2_Missense_Mutation_p.E684K|NFATC4_ENST00000554473.1_Missense_Mutation_p.E187K|NFATC4_ENST00000554661.1_Missense_Mutation_p.E582K|NFATC4_ENST00000250373.4_Missense_Mutation_p.E652K	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	652					cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		GACTGTCCCCGAGTACAGCAA	0.577000													24	221					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51253597	51253597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:51253597G>A	ENST00000404971.1	-	3	2122	c.783C>T	c.(781-783)ttC>ttT	p.F261F	NRXN1_ENST00000405581.1_Intron|NRXN1_ENST00000402717.3_Intron|NRXN1_ENST00000401669.2_Intron|NRXN1_ENST00000406859.3_Intron|NRXN1_ENST00000405472.3_Intron|NRXN1_ENST00000406316.2_Intron	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	258					adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTGAAGACCGAATTTTATTT	0.378000													5	12					0	0	1	0	0
PGM5P2	595135	broad.mit.edu	37	9	69113627	69113627	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:69113627C>T	ENST00000591037.1	-	0	1018					NR_002836.2																						CCATATTCTCCTCCTTTCATT	0.458000													6	60					0	0	1	0	0
NECAB2	54550	broad.mit.edu	37	16	84024221	84024221	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84024221G>A	ENST00000565691.1	+	4	1055	c.333G>A	c.(331-333)caG>caA	p.Q111Q	NECAB2_ENST00000305202.4_Silent_p.Q194Q			Q7Z6G3	NECA2_HUMAN	N-terminal EF-hand calcium binding protein 2	194	EF-hand 2.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding	p.Q194Q(1)		endometrium(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19						TCGAGGAACAGACCAGCCAGC	0.627000													20	42					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113532972	113532972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113532972C>T	ENST00000257600.3	+	7	2015	c.1512C>T	c.(1510-1512)acC>acT	p.T504T	DTX1_ENST00000547974.1_3'UTR	NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	504					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						ATACCCAGACCATCCGCATCG	0.642000													7	102					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56417688	56417688	+	Missense_Mutation	SNP	G	G	A	rs112177059		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56417688G>A	ENST00000370754.5	-	61	15808	c.15809C>T	c.(15808-15810)tCg>tTg	p.S5270L	DST_ENST00000361203.3_Missense_Mutation_p.S5090L|DST_ENST00000312431.6_3'UTR|DST_ENST00000446842.2_Missense_Mutation_p.S4766L|DST_ENST00000370769.4_Missense_Mutation_p.S5092L|DST_ENST00000370788.2_Missense_Mutation_p.S3004L|DST_ENST00000421834.2_Missense_Mutation_p.S3004L|DST_ENST00000244364.6_Missense_Mutation_p.S2678L			Q03001	DYST_HUMAN	dystonin	5090					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity	p.S5092L(1)		NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GGATCCCAGCGAATCATGGAT	0.418000													39	217					0	0	1	0	0
NNMT	4837	broad.mit.edu	37	11	114168706	114168706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:114168706G>A	ENST00000535401.1	+	4	452	c.188G>A	c.(187-189)gGc>gAc	p.G63D	NNMT_ENST00000299964.3_Missense_Mutation_p.G63D|NNMT_ENST00000541754.1_5'UTR|RP11-64D24.2_ENST00000544925.1_RNA			P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	63	S-adenosyl-L-methionine binding.				xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	ATTGACATCGGCTCTGGCCCC	0.512000													45	85					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131027	72131027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72131027G>A	ENST00000265381.4	-	2	1322	c.1100C>T	c.(1099-1101)tCg>tTg	p.S367L		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	367					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GGTGTAAGGCGAACGGATGGT	0.617000													29	78					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34078170	34078170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34078170G>A	ENST00000389232.4	+	66	9646	c.9576G>A	c.(9574-9576)atG>atA	p.M3192I	RYR3_ENST00000415757.3_Missense_Mutation_p.M3192I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3192					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTCCTGGATGAAGCGCATTG	0.498000													60	160					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81568677	81568677	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81568677G>A	ENST00000548058.1	+	8	2119	c.1209G>A	c.(1207-1209)caG>caA	p.Q403Q	ACSS3_ENST00000548324.1_Silent_p.Q85Q|ACSS3_ENST00000261206.3_Silent_p.Q402Q			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	403						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TCCGTCAACAGGACCCTGGGG	0.493000													13	59					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18554486	18554486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18554486G>A	ENST00000251296.1	+	2	548	c.165G>A	c.(163-165)cgG>cgA	p.R55R		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	55	Ig-like 1.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		GGCGCATGCGGGAGATCGTGT	0.582000													35	66					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73558989	73558989	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73558989C>T	ENST00000224721.6	+	50	7196	c.7191C>T	c.(7189-7191)atC>atT	p.I2397I	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Silent_p.I152I	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2392	Cadherin 22.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding	p.I2397I(1)		NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACCTGGAAATCGTGGACATCA	0.617000													7	49					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34018827	34018827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:34018827G>A	ENST00000382499.2	-	24	3239	c.3240C>T	c.(3238-3240)tcC>tcT	p.S1080S	SYNJ1_ENST00000322229.7_Silent_p.S1041S|SYNJ1_ENST00000382491.3_Silent_p.S1036S|SYNJ1_ENST00000357345.3_Silent_p.S1041S|SYNJ1_ENST00000433931.2_Silent_p.S1080S	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1041	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						AAGAGCTGGGGGAAGTACCAA	0.522000													6	106					0	0	1	0	0
RRP15	51018	broad.mit.edu	37	1	218458698	218458698	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:218458698G>A	ENST00000366932.3	+	1	70	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	RRP15_ENST00000491428.1_3'UTR	NM_016052.3	NP_057136.2	Q9Y3B9	RRP15_HUMAN	ribosomal RNA processing 15 homolog (S. cerevisiae)	14						mitochondrion|nucleolus	protein binding		ACBD6/RRP15(2)	NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14				all cancers(67;0.0315)|OV - Ovarian serous cystadenocarcinoma(81;0.0411)|GBM - Glioblastoma multiforme(131;0.06)|Epithelial(68;0.248)		GAGTGAGGAAGAAAACCTGAA	0.547000													22	59					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64526872	64526872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64526872C>T	ENST00000498707.1	-	36	5762	c.5420G>A	c.(5419-5421)gGg>gAg	p.G1807E	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.G1779E	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1807	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GCGCCGGCTCCCGTTATAGGG	0.478000													46	103					0	0	1	0	0
NIPA1	123606	broad.mit.edu	37	15	23049282	23049282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23049282G>A	ENST00000437912.2	-	5	1609	c.312C>T	c.(310-312)atC>atT	p.I104I	NIPA1_ENST00000561183.1_Silent_p.I104I|NIPA1_ENST00000337435.4_Silent_p.I179I|NIPA1_ENST00000538684.1_Silent_p.I9I			Q7RTP0	NIPA1_HUMAN	non imprinted in Prader-Willi/Angelman syndrome 1	179					cell death	early endosome|integral to membrane|plasma membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|skin(1)	15		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		GGGCCGGCGCGATCCAGAAGA	0.607000													5	23					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15326904	15326904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:15326904G>A	ENST00000281513.5	-	50	6698	c.6673C>T	c.(6673-6675)Cgc>Tgc	p.R2225C	NBAS_ENST00000441750.1_Missense_Mutation_p.R2105C	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	2225										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TACAAAGAGCGACACATTTTC	0.428000													39	112					0	0	1	0	0
C14orf166	51637	broad.mit.edu	37	14	52460467	52460467	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52460467C>T	ENST00000261700.3	+	3	378	c.213C>T	c.(211-213)ttC>ttT	p.F71F	C14orf166_ENST00000556760.1_Silent_p.F71F	NM_016039.2	NP_057123.1	Q9Y224	CN166_HUMAN	chromosome 14 open reading frame 166	71						microtubule organizing center|nucleus|perinuclear region of cytoplasm|tRNA-splicing ligase complex	identical protein binding			endometrium(1)|large_intestine(3)|lung(2)	6	Breast(41;0.0639)|all_epithelial(31;0.101)					ACTGTCCTTTCAAGATTCAAG	0.373000													20	62					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75509332	75509332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75509332C>T	ENST00000228027.7	+	7	1130	c.870C>T	c.(868-870)ttC>ttT	p.F290F	DGAT2_ENST00000376262.3_Silent_p.F247F	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	290					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					AGGTGATCTTCGAGGAGGGCT	0.537000													69	159					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126136884	126136884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126136884G>A	ENST00000373631.3	+	11	3417	c.3416G>A	c.(3415-3417)aGc>aAc	p.S1139N	CRB2_ENST00000373629.2_Missense_Mutation_p.S807N	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	1139	EGF-like 14.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						AAGGAGTGCAGCCTGAATGTC	0.662000													5	56					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95847020	95847020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95847020C>T	ENST00000398107.2	+	4	843	c.321C>T	c.(319-321)tcC>tcT	p.S107S	ZNF2_ENST00000425369.1_Silent_p.S69S|ZNF2_ENST00000295210.6_Silent_p.S111S|ZNF2_ENST00000340539.5_Silent_p.S149S|ZNF2_ENST00000453539.2_Silent_p.S162S	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		GTAAGAAATCCCTCTCCCGGG	0.522000													26	78					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79440623	79440623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79440623C>T	ENST00000264895.6	+	67	10968	c.10528C>T	c.(10528-10530)Ctc>Ttc	p.L3510F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3505					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGACACTGTTCTCTGGAGAAC	0.473000													90	167					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133911710	133911710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133911710G>A	ENST00000361069.4	+	4	1100	c.967G>A	c.(967-969)Gag>Aag	p.E323K	LAMC3_ENST00000480883.1_3'UTR	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	323	Laminin EGF-like 1.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GGCTGCCCACGAGTGTCTGCG	0.677000													14	43					0	0	1	0	0
TRIM4	89122	broad.mit.edu	37	7	99489896	99489896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99489896C>T	ENST00000355947.2	-	7	1522	c.1393G>A	c.(1393-1395)Gga>Aga	p.G465R	TRIM4_ENST00000349062.2_Missense_Mutation_p.G439R	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	465	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				AGGTGCACTCCGTCCACAGCG	0.537000													60	126					0	0	1	0	0
STS	412	broad.mit.edu	37	X	7171326	7171326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:7171326C>T	ENST00000217961.4	+	2	321	c.101C>T	c.(100-102)gCt>gTt	p.A34V		NM_000351.4	NP_000342.2	P08842	STS_HUMAN	steroid sulfatase (microsomal), isozyme S	34					female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(1)	27		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CTGGTGATGGCTGACGACCTC	0.502000									Ichthyosis				15	33					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127944915	127944915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:127944915G>A	ENST00000335247.7	-	8	1181	c.1051C>T	c.(1051-1053)Cat>Tat	p.H351Y	CYP27C1_ENST00000409327.1_Missense_Mutation_p.H351Y	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	351						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		GTTTTTGCATGAACAGCATTG	0.453000													34	71					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6472692	6472692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6472692G>A	ENST00000358945.3	-	2	1041	c.601C>T	c.(601-603)Cgt>Tgt	p.R201C	SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000543768.1_Missense_Mutation_p.R224C|SCNN1A_ENST00000396966.2_Missense_Mutation_p.R201C|SCNN1A_ENST00000360168.3_Missense_Mutation_p.R260C|SCNN1A_ENST00000228916.2_Missense_Mutation_p.R201C|SCNN1A_ENST00000540037.1_5'UTR			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	201					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	CGGGCTCGACGGGCCCCGTGA	0.726000													12	21					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16032908	16032908	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16032908C>T	ENST00000326742.7	-	8	1055	c.1054G>A	c.(1054-1056)Gaa>Aaa	p.E352K	CYP4F11_ENST00000402119.3_Missense_Mutation_p.E352K|CYP4F11_ENST00000248041.7_Missense_Mutation_p.E352K			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	352					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						CGGCACTGTTCCTGGTATTCT	0.522000													30	52					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097327	167097327	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167097327G>A	ENST00000361200.2	+	6	3125	c.2959G>A	c.(2959-2961)Gaa>Aaa	p.E987K	DUSP27_ENST00000271385.5_Missense_Mutation_p.E987K|DUSP27_ENST00000443333.1_Missense_Mutation_p.E987K|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	987	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCAGTCAGAGGAACAGGACAC	0.517000													8	122					0	0	1	0	0
PAPOLA	10914	broad.mit.edu	37	14	97002296	97002296	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:97002296C>T	ENST00000216277.8	+	11	1210	c.990C>T	c.(988-990)tcC>tcT	p.S330S	PAPOLA_ENST00000392990.2_Silent_p.S330S	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	330					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ACAATGTGTCCGTTTCAACAC	0.413000													37	74					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75609555	75609555	+	Silent	SNP	C	C	T	rs147867930		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75609555C>T	ENST00000294638.5	+	7	1300	c.636C>T	c.(634-636)gcC>gcT	p.A212A	LHX8_ENST00000356261.3_Silent_p.A202A	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	212						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						TGGAAGGTGCCCTCCTCACAG	0.393000													15	46					0	0	1	0	0
PROSER2	254427	broad.mit.edu	37	10	11911536	11911536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11911536C>T	ENST00000277570.5	+	4	593	c.439C>T	c.(439-441)Cct>Tct	p.P147S	PROSER2-AS1_ENST00000445498.1_RNA|PROSER2-AS1_ENST00000453242.1_RNA	NM_153256.3	NP_694988.3			proline and serine-rich protein 2																		TGCTGAGACTCCTCCACCTCC	0.667000													13	35					0	0	1	0	0
AARD	441376	broad.mit.edu	37	8	117954928	117954928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:117954928G>A	ENST00000378279.3	+	2	501	c.456G>A	c.(454-456)gcG>gcA	p.A152A	AARD_ENST00000523536.1_3'UTR	NM_001025357.2	NP_001020528.1	Q4LEZ3	AARD_HUMAN	alanine and arginine rich domain containing protein	152																	ATGATGCTGCGAATCCGGAAT	0.502000													19	67					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960618	73960618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73960618C>T	ENST00000373468.1	-	3	4425	c.3774G>A	c.(3772-3774)ttG>ttA	p.L1258L	KIAA2022_ENST00000055682.5_Silent_p.L1258L			Q5QGS0	K2022_HUMAN	KIAA2022	1258					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TACATTCAGCCAATGTCTTCC	0.507000													19	4					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105803263	105803263	+	Silent	SNP	G	G	A	rs148868816		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105803263G>A	ENST00000353479.5	-	35	2801	c.2511C>T	c.(2509-2511)gcC>gcT	p.A837A	COL17A1_ENST00000369733.3_Silent_p.A837A	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	837	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ACTGACCTGGGGCACCTGGAG	0.557000													14	29					0	0	1	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629337	9629337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:9629337G>A	ENST00000382492.2	-	1	1126	c.808C>T	c.(808-810)Cct>Tct	p.P270S	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	270					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						TGTCCAGAAGGGTATATACCA	0.373000													34	96					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123285917	123285917	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123285917C>T	ENST00000253079.6	+	9	1568	c.1224C>T	c.(1222-1224)aaC>aaT	p.N408N	CCDC62_ENST00000392441.4_Silent_p.N408N|CCDC62_ENST00000392440.2_Silent_p.N169N|CCDC62_ENST00000537566.1_Silent_p.N169N	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	408						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		AGAAACACAACCTCCCTTGGT	0.413000													9	40					0	0	1	0	0
PABPC1L	80336	broad.mit.edu	37	20	43559289	43559289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43559289C>T	ENST00000255136.3	+	8	1243	c.1161C>T	c.(1159-1161)tcC>tcT	p.S387S	PABPC1L_ENST00000537323.1_3'UTR|PABPC1L_ENST00000217074.4_3'UTR|PABPC1L_ENST00000490798.1_3'UTR|PABPC1L_ENST00000217073.2_Silent_p.S387S	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like	387							nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						AGCGCCTCTCCACCATGCGGA	0.652000													42	231					0	0	1	0	0
ALDH3A1	218	broad.mit.edu	37	17	19642357	19642357	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:19642357C>T	ENST00000457500.2	-	8	1497	c.1168G>A	c.(1168-1170)Gat>Aat	p.D390N	ALDH3A1_ENST00000494157.2_Missense_Mutation_p.D317N|ALDH3A1_ENST00000225740.6_Missense_Mutation_p.D390N|ALDH3A1_ENST00000395555.3_Missense_Mutation_p.D326N|ALDH3A1_ENST00000444455.1_Missense_Mutation_p.D390N	NM_001135168.1	NP_001128640.1	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3 family, member A1	390					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	ACGATGACATCGTTGGCCGCC	0.632000													18	13					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96533503	96533503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:96533503C>T	ENST00000389672.5	+	1	74	c.36C>T	c.(34-36)tcC>tcT	p.S12S	EPHA6_ENST00000470610.2_Silent_p.S12S	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	0						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CGAGGAGCTCCCCGGCGCCGC	0.711000													9	24					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125141072	125141072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125141072C>T	ENST00000362012.2	+	5	376	c.371C>T	c.(370-372)cCc>cTc	p.P124L	PTGS1_ENST00000373698.5_Missense_Mutation_p.P15L|PTGS1_ENST00000540753.1_Missense_Mutation_p.P99L|PTGS1_ENST00000223423.4_Missense_Mutation_p.P124L	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	124					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	AACCTTATCCCCAGTCCCCCC	0.537000													13	58					0	0	1	0	0
TAS2R4	50832	broad.mit.edu	37	7	141478552	141478552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141478552C>T	ENST00000247881.2	+	1	311	c.264C>T	c.(262-264)ttC>ttT	p.F88F	SSBP1_ENST00000465582.1_Intron	NM_016944.1	NP_058640.1	Q9NYW5	TA2R4_HUMAN	taste receptor, type 2, member 4	88					sensory perception of taste	cilium membrane	taste receptor activity			endometrium(1)|large_intestine(4)|lung(2)	7	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		TGTTGTGTTTCATGTTTTTGG	0.418000													44	144					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130287237	130287237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130287237G>A	ENST00000358511.6	+	5	2221	c.2190G>A	c.(2188-2190)acG>acA	p.T730T	COL6A6_ENST00000453409.2_Silent_p.T730T	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	730	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCCTCATCACGGATGGTGAAG	0.517000													14	83					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91795728	91795728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91795728C>T	ENST00000394232.1	+	4	1232	c.762C>T	c.(760-762)gcC>gcT	p.A254A	SV2B_ENST00000330276.4_Silent_p.A254A|SV2B_ENST00000545111.2_Silent_p.A103A	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	254					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CTGCCATGGCCTGGAGCATCA	0.542000													13	59					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31232216	31232216	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31232216G>A	ENST00000322122.3	+	5	1001		c.e5-1			NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72						exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						TCTCTCTCCAGAAATACTGCC	0.542000													36	103					0	0	1	0	0
DNAAF3	352909	broad.mit.edu	37	19	55672734	55672734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55672734G>A	ENST00000527223.2	-	7	921	c.920C>T	c.(919-921)gCc>gTc	p.A307V	CTD-2587H24.5_ENST00000591665.1_RNA|DNAAF3_ENST00000455045.1_Missense_Mutation_p.A185V|DNAAF3_ENST00000524407.2_Missense_Mutation_p.A239V|DNAAF3_ENST00000391720.4_Missense_Mutation_p.A286V	NM_001256714.1	NP_001243643.1	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	239																	GAGTTCAAAGGCGACGCCTGT	0.667000													8	15					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56083794	56083794	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56083794G>A	ENST00000429804.2	-	8	1952	c.1392C>T	c.(1390-1392)ttC>ttT	p.F464F	CTCFL_ENST00000426658.2_3'UTR|CTCFL_ENST00000422869.2_Silent_p.F514F|CTCFL_ENST00000422109.2_Intron|CTCFL_ENST00000423479.2_Silent_p.F514F|CTCFL_ENST00000371196.2_Silent_p.F514F|CTCFL_ENST00000243914.3_Silent_p.F514F|CTCFL_ENST00000539382.1_Silent_p.F309F|CTCFL_ENST00000432255.2_Silent_p.F370F|CTCFL_ENST00000433949.2_Silent_p.F514F|CTCFL_ENST00000502686.2_Silent_p.F252F	NM_001269046.1	NP_001255975.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	514					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			AAAGGCAGGTGAATGGTTTCT	0.438000													34	98					0	0	1	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186761062	186761062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186761062G>A	ENST00000169298.3	+	4	1245	c.571G>A	c.(571-573)Gga>Aga	p.G191R	ST6GAL1_ENST00000448044.1_Missense_Mutation_p.G191R|ST6GAL1_ENST00000457772.2_Intron	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	191					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		GTCGTCAGCGGGATCTCTGAA	0.522000													26	141					0	0	1	0	0
FAM198B	51313	broad.mit.edu	37	4	159092246	159092246	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:159092246C>T	ENST00000296530.8	-	2	903	c.282G>A	c.(280-282)gaG>gaA	p.E94E	FAM198B_ENST00000393807.5_Silent_p.E94E|RP11-597D13.9_ENST00000503611.1_RNA|FAM198B_ENST00000592057.1_Silent_p.E94E|FAM198B_ENST00000589306.1_Intron|FAM198B_ENST00000585682.1_Silent_p.E94E	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	94						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						TGCCCTGGGACTCTGGAGGGG	0.632000													25	64					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33313498	33313498	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:33313498C>T	ENST00000242067.6	+	9	1467	c.946C>T	c.(946-948)Caa>Taa	p.Q316*	BBS9_ENST00000396127.2_Nonsense_Mutation_p.Q316*|BBS9_ENST00000354265.4_Nonsense_Mutation_p.Q316*|BBS9_ENST00000355070.2_Nonsense_Mutation_p.Q316*|BBS9_ENST00000350941.3_Nonsense_Mutation_p.Q316*|BBS9_ENST00000425508.2_Nonsense_Mutation_p.Q271*	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	316					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			GCATATTTATCAAGATGTGAC	0.353000									Bardet-Biedl syndrome				19	37					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56459573	56459573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56459573C>T	ENST00000291971.3	+	1	376	c.305C>T	c.(304-306)tCg>tTg	p.S102L	NLRP8_ENST00000590542.1_Missense_Mutation_p.S102L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	102	DAPIN.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GATGTGACTTCGAACATCTTT	0.507000													23	41					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43372307	43372307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43372307G>A	ENST00000244296.2	-	5	1326	c.1189C>T	c.(1189-1191)Cgt>Tgt	p.R397C	PSG1_ENST00000403380.3_Missense_Mutation_p.R304C|PSG1_ENST00000312439.6_Missense_Mutation_p.R397C|PSG1_ENST00000595356.1_Missense_Mutation_p.R397C|PSG1_ENST00000595124.1_Missense_Mutation_p.R304C|PSG1_ENST00000436291.2_Missense_Mutation_p.R397C	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				GCTGAGTTACGAACAGAGCAA	0.448000													139	293					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141955043	141955043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141955043G>A	ENST00000552471.1	-	3	587	c.268C>T	c.(268-270)Cat>Tat	p.H90Y	PRSS58_ENST00000547058.2_Missense_Mutation_p.H90Y			Q8IYP2	PRS58_HUMAN	protease, serine, 58	90	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						AAGTGTGGATGATGAATCATC	0.413000													34	104					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844988	18844988	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18844988C>T	ENST00000412938.1	+	0	3238																											GCAGCGGCCTCCTTGAAGATC	0.572000													9	38					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19560691	19560691	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19560691C>T	ENST00000328041.6	+	4	593	c.396C>T	c.(394-396)ttC>ttT	p.F132F		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	132						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ATGACTTCTTCGTCCCTTCCT	0.502000													48	77					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44974300	44974300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:44974300G>A	ENST00000340446.4	-	1	2182	c.1891C>T	c.(1891-1893)Ccc>Tcc	p.P631S		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	631	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		ACTTCAGCGGGGGCCTCCTCA	0.637000													5	27					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46942907	46942907	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46942907G>A	ENST00000429979.1	-	4	1183	c.579C>T	c.(577-579)ttC>ttT	p.F193F	KIAA0226L_ENST00000409879.2_Silent_p.F36F|KIAA0226L_ENST00000534925.1_Silent_p.F58F|KIAA0226L_ENST00000378797.2_Silent_p.F193F|KIAA0226L_ENST00000378784.4_Silent_p.F126F|KIAA0226L_ENST00000378781.3_Silent_p.F193F|KIAA0226L_ENST00000322896.6_Silent_p.F36F|KIAA0226L_ENST00000378787.3_Silent_p.F193F|KIAA0226L_ENST00000389908.3_Silent_p.F193F	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	193										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						CCTCTGGTGAGAAGGAATTCG	0.358000													42	119					0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2511077	2511077	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2511077C>T	ENST00000569496.1	+	4	516	c.457C>T	c.(457-459)Cct>Tct	p.P153S	C16orf59_ENST00000563531.1_Missense_Mutation_p.P153S|C16orf59_ENST00000361837.4_Missense_Mutation_p.P153S|C16orf59_ENST00000483320.1_5'UTR			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	153										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				CAAGGGCCACCCTGAGCGCCG	0.706000													6	52					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22902738	22902738	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22902738C>T	ENST00000166244.3	+	3	260	c.188C>T	c.(187-189)tCc>tTc	p.S63F	EPHA8_ENST00000374644.4_Missense_Mutation_p.S63F|EPHA8_ENST00000538803.1_Missense_Mutation_p.S63F	NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	63						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GTGGACGAGTCCTTCCAGCCC	0.612000													46	128					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1262101	1262101	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1262101G>A	ENST00000348261.5	+	25	4970	c.4722G>A	c.(4720-4722)gaG>gaA	p.E1574E	CACNA1H_ENST00000565831.1_Silent_p.E1574E|CACNA1H_ENST00000358590.4_Silent_p.E1574E	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1574					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGCGGCGAGAGGAGAAGCGGC	0.692000													13	82					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907882	12907882	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12907882C>T	ENST00000317869.6	-	2	486	c.261G>A	c.(259-261)gaG>gaA	p.E87E		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TCACTTTTGGCTCTGCAGCCA	0.478000													26	267					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79351739	79351739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79351739G>A	ENST00000350881.2	+	3	614	c.424G>A	c.(424-426)Gag>Aag	p.E142K	THBS4_ENST00000511733.1_Missense_Mutation_p.E51K|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	142	TSP N-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CGGCTCCCTAGAGCTCTACCT	0.572000													29	86					0	0	1	0	0
ME3	10873	broad.mit.edu	37	11	86209145	86209145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:86209145C>T	ENST00000543262.1	-	6	891	c.565G>A	c.(565-567)Gag>Aag	p.E189K	RP11-317J19.1_ENST00000524610.1_RNA|ME3_ENST00000393324.3_Missense_Mutation_p.E189K|ME3_ENST00000525957.1_5'UTR|ME3_ENST00000359636.2_Missense_Mutation_p.E189K|ME3_ENST00000323418.6_Missense_Mutation_p.E127K	NM_001161586.1	NP_001155058.1	Q16798	MAON_HUMAN	malic enzyme 3, NADP(+)-dependent, mitochondrial	189					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			endometrium(4)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|skin(3)|stomach(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	AGGATGCGCTCCCCATCAGTC	0.627000													31	85					0	0	1	0	0
SLC3A2	6520	broad.mit.edu	37	11	62655996	62655996	+	Missense_Mutation	SNP	C	C	T	rs138529750		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62655996C>T	ENST00000377892.1	+	13	2041	c.1817C>T	c.(1816-1818)tCg>tTg	p.S606L	SLC3A2_ENST00000338663.7_Missense_Mutation_p.S474L|SLC3A2_ENST00000535296.1_Missense_Mutation_p.S544L|SLC3A2_ENST00000377891.2_Missense_Mutation_p.S576L|SLC3A2_ENST00000536981.1_Missense_Mutation_p.S120L|SLC3A2_ENST00000377889.2_Missense_Mutation_p.S513L|SLC3A2_ENST00000377890.2_Missense_Mutation_p.S575L			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	575					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						GTGGGCCTCTCGGCTGGACTG	0.642000													67	153					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137727218	137727218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137727218C>T	ENST00000314358.5	+	8	2097	c.1897C>T	c.(1897-1899)Cct>Tct	p.P633S	KDM3B_ENST00000394866.1_Missense_Mutation_p.P289S|KDM3B_ENST00000542866.1_Intron	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	633					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						CCGAGAAGAGCCTTCTAATCC	0.493000													36	194					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33855038	33855038	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33855038G>A	ENST00000389232.4	+	11	1043	c.972_splice	c.e11-1	p.E325_splice	RYR3_ENST00000415757.3_Splice_Site_p.E325_splice	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	325	MIR 4.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TATGAATTAGGAACTCAAGGA	0.388000													12	31					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703819	55703819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55703819G>A	ENST00000301532.3	-	1	57	c.58C>T	c.(58-60)Cca>Tca	p.P20S		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GGGCGAGTTGGAAAACCTAAT	0.373000													16	53					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300912	88300912	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88300912G>A	ENST00000418177.2	-	8	2306	c.1939C>T	c.(1939-1941)Cag>Tag	p.Q647*	GRM5_ENST00000305447.4_Nonsense_Mutation_p.Q647*|GRM5_ENST00000393297.1_Nonsense_Mutation_p.Q647*|GRM5_ENST00000455756.2_Nonsense_Mutation_p.Q647*|GRM5_ENST00000305432.5_Nonsense_Mutation_p.Q647*			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	647					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CCAATTCTCTGAAGGTAGCAG	0.493000													5	33					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33578885	33578885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33578885G>A	ENST00000262873.7	+	22	2362	c.2270G>A	c.(2269-2271)gGg>gAg	p.G757E		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	715	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TGCCGCCAAGGGTTCCCCAAC	0.652000													17	46					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113212415	113212415	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113212415C>T	ENST00000401783.2	-	24	4363	c.4027G>A	c.(4027-4029)Gga>Aga	p.G1343R	SVEP1_ENST00000374469.1_Missense_Mutation_p.G1320R|SVEP1_ENST00000302728.8_Missense_Mutation_p.G1343R|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1343	EGF-like 4; calcium-binding (Potential).				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ACGTTCTTTCCACATCGGGTA	0.458000													29	283					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125671766	125671766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125671766G>A	ENST00000431078.1	+	24	4186	c.3822G>A	c.(3820-3822)atG>atA	p.M1274I		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1274					cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CGAGCCAGATGAAGGAGAAGG	0.443000													38	86					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	520865	520865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:520865C>T	ENST00000453061.2	+	10	2213	c.2107C>T	c.(2107-2109)Ctc>Ttc	p.L703F	PIGG_ENST00000383028.4_Missense_Mutation_p.L570F|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000310340.5_Missense_Mutation_p.L695F|PIGG_ENST00000504346.1_Missense_Mutation_p.L614F	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	703					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CCTGGCTGCCCTCTCCCTCCT	0.572000													14	35					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28193847	28193847	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:28193847C>T	ENST00000302326.4	-	1	3639	c.2685G>A	c.(2683-2685)ggG>ggA	p.G895G		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	895							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						TGCTACTGGTCCCGGACGGGC	0.711000			T	ETV6	"""AML, meningioma"""								9	20					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	69978115	69978115	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:69978115C>T	ENST00000355303.5	+	11	1493	c.1188C>T	c.(1186-1188)gcC>gcT	p.A396A	ANO1_ENST00000538023.1_Silent_p.A396A|ANO1_ENST00000531349.1_Silent_p.A131A|ANO1_ENST00000316296.5_Silent_p.A368A|ANO1_ENST00000398543.2_Silent_p.A280A|RP11-805J14.3_ENST00000530525.1_RNA|ANO1_ENST00000530676.1_Silent_p.A280A	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	396					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						CAGCCTGCGCCACGGCCCGCG	0.582000													8	11					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61819654	61819654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61819654G>A	ENST00000373827.2	-	40	5019	c.4849C>T	c.(4849-4851)Ccc>Tcc	p.P1617S	ANK3_ENST00000503366.1_Missense_Mutation_p.P1624S|RP11-388P9.2_ENST00000414383.1_RNA|ANK3_ENST00000280772.1_Intron|ANK3_ENST00000355288.2_Missense_Mutation_p.P757S	NM_001204403.1	NP_001191332.1	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3674	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTTCTAAGGGGAGATTCTATG	0.502000													31	91					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51936919	51936919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51936919C>T	ENST00000371117.3	-	8	871	c.596G>A	c.(595-597)gGa>gAa	p.G199E	PKHD1_ENST00000340994.4_Missense_Mutation_p.G199E	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	199	IPT/TIG 2.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.G199E(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TCACCAGCTTCCCATCTGCCT	0.413000													10	66					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19183983	19183983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19183983G>A	ENST00000375371.3	-	2	346	c.325C>T	c.(325-327)Cag>Tag	p.Q109*	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	109					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AGCACCGGCTGGACATTGTTG	0.552000													32	91					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94693284	94693284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94693284G>A	ENST00000282020.4	+	16	2917	c.2659G>A	c.(2659-2661)Gat>Aat	p.D887N	GRID2_ENST00000510992.1_Missense_Mutation_p.D792N	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	887					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTTGTGCACAGATGACGACAG	0.448000													62	126					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135673	156135673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156135673C>T	ENST00000329476.3	+	2	1071	c.582C>T	c.(580-582)atC>atT	p.I194I	NPY2R_ENST00000506608.1_Silent_p.I194I	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	194					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				TGATTGAGATCATCCCGGACT	0.517000													48	102					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101834534	101834534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101834534G>A	ENST00000506729.1	-	1	186	c.15C>T	c.(13-15)gtC>gtT	p.V5V	SLCO6A1_ENST00000379810.1_Silent_p.V5V|SLCO6A1_ENST00000513675.1_Silent_p.V5V|SLCO6A1_ENST00000389019.3_Silent_p.V5V|SLCO6A1_ENST00000379807.3_Silent_p.V5V			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	5						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AGTGCCGGGCGACGCCTACGA	0.706000													29	193					0	0	1	0	0
TAS2R7	50837	broad.mit.edu	37	12	10954432	10954432	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10954432G>A	ENST00000240687.2	-	1	794	c.738C>T	c.(736-738)gcC>gcT	p.A246A		NM_023919.2	NP_076408.1	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	246					sensory perception of taste	integral to membrane	taste receptor activity			kidney(1)|large_intestine(1)|lung(3)|skin(2)|stomach(3)	10						ACAAATAGTAGGCAATAAAGA	0.493000													14	56					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70938397	70938397	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70938397C>T	ENST00000334414.6	-	22	5478	c.5434G>A	c.(5434-5436)Gaa>Aaa	p.E1812K	PTPRB_ENST00000550857.1_Missense_Mutation_p.E1504K|PTPRB_ENST00000451516.2_Missense_Mutation_p.E1504K|PTPRB_ENST00000550358.1_Missense_Mutation_p.E1724K|PTPRB_ENST00000538708.1_Missense_Mutation_p.E1504K|PTPRB_ENST00000261266.5_Missense_Mutation_p.E1594K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1594	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTTGTGAATTCCTTCAGGTCC	0.363000													12	46					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	550076	550076	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:550076C>T	ENST00000239830.4	+	12	1413	c.1234C>T	c.(1234-1236)Cga>Tga	p.R412*	CCDC77_ENST00000422000.1_Nonsense_Mutation_p.R380*|CCDC77_ENST00000540180.1_Nonsense_Mutation_p.R380*|CCDC77_ENST00000412006.2_Nonsense_Mutation_p.R380*	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	412						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			ATTGGAGCGTCGACGTATCCT	0.428000													15	57					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10209890	10209890	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10209890C>T	ENST00000418404.3	-	36	5515	c.5352G>A	c.(5350-5352)gaG>gaA	p.E1784E	MYH13_ENST00000570743.1_Silent_p.E1784E|MYH13_ENST00000252172.4_Silent_p.E1784E			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1784					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TCTTCATCCGCTCCAGGTGGG	0.577000													50	64					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768532	117768532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117768532C>T	ENST00000317775.6	-	2	1028	c.343G>A	c.(343-345)Ggg>Agg	p.G115R	NOS1_ENST00000344089.3_Missense_Mutation_p.G115R|NOS1_ENST00000338101.4_Missense_Mutation_p.G115R	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	115	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTGGGGGTCCCATCACCTGTA	0.632000													22	38					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43836363	43836363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43836363C>T	ENST00000372781.3	+	2	482	c.425C>T	c.(424-426)cCt>cTt	p.P142L	SEMG1_ENST00000244069.6_Missense_Mutation_p.P142L	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				ACACAAAATCCTTCTCAAGAT	0.403000													37	103					0	0	1	0	0
KCTD14	65987	broad.mit.edu	37	11	77727683	77727683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:77727683C>T	ENST00000353172.5	-	2	768	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	KCTD14_ENST00000533144.1_Missense_Mutation_p.E212K	NM_001203260.1|NM_001203262.1|NM_023930.3	NP_001190189.1|NP_001190191.1|NP_076419.2	Q9BQ13	KCD14_HUMAN	potassium channel tetramerization domain containing 14	242						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.E242K(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	15	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			AAATGGAATTCGTTTCTTTTG	0.448000													21	44					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075750	145075750	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145075750C>T	ENST00000369359.4	-	1	151	c.113G>A	c.(112-114)cGa>cAa	p.R38Q	PDE4DIP_ENST00000369345.4_Missense_Mutation_p.R38Q|PDE4DIP_ENST00000369348.3_Missense_Mutation_p.R38Q|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R38Q			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGAGGGGTTCGCGTCGCGTC	0.731000			T	PDGFRB	MPD								17	102					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71604584	71604584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71604584C>T	ENST00000355962.4	-	8	1043	c.910G>A	c.(910-912)Gag>Aag	p.E304K	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	304					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	ATTATCACCTCATTGCCAAAA	0.473000													16	49					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89388907	89388907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89388907C>T	ENST00000439576.2	+	7	1597	c.1223C>T	c.(1222-1224)tCc>tTc	p.S408F	ACAN_ENST00000558207.1_Missense_Mutation_p.S408F|ACAN_ENST00000559004.1_Missense_Mutation_p.S408F|ACAN_ENST00000561243.1_Missense_Mutation_p.S408F|ACAN_ENST00000352105.7_Missense_Mutation_p.S408F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	408					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TTCGAGGTCTCCCCCAGTCCC	0.602000													16	60					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11308580	11308580	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:11308580G>A	ENST00000380732.3	-	2	606	c.607C>T	c.(607-609)Cag>Tag	p.Q203*	ARHGAP6_ENST00000337414.4_Intron|ARHGAP6_ENST00000413512.3_Intron|ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000380736.1_Intron			O43182	RHG06_HUMAN	Rho GTPase activating protein 6	196					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CCTAAGATCTGAAGATCATAC	0.363000													26	31					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121420796	121420796	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121420796G>A	ENST00000260197.7	+	15	2308	c.2180_splice	c.e15+1	p.G727_splice		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	727					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GAGAACGAGAGGGTATGTATC	0.502000													25	57					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167094752	167094752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167094752C>T	ENST00000375387.4	-	20	3996	c.3656G>A	c.(3655-3657)aGg>aAg	p.R1219K	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.R1207K|SCN9A_ENST00000409435.1_Missense_Mutation_p.R1218K|SCN9A_ENST00000303354.6_Missense_Mutation_p.R1219K			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1218						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.R1207K(1)		NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	GGTCTTTTTCCTTTCAATATA	0.294000													7	18					0	0	1	0	0
PRDM11	56981	broad.mit.edu	37	11	45204610	45204610	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:45204610T>G	ENST00000263765.4	+	5	773	c.524T>G	c.(523-525)aTc>aGc	p.I175S	PRDM11_ENST00000528980.1_3'UTR|PRDM11_ENST00000530656.1_Missense_Mutation_p.I175S|PRDM11_ENST00000424263.2_Missense_Mutation_p.I141S			Q9NQV5	PRD11_HUMAN	PR domain containing 11	175	SET.									endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	26						AAGGGCCACATCTTCGGCCCC	0.597000											OREG0020926	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	16					0	0	1	0	0
C11orf42	160298	broad.mit.edu	37	11	6231270	6231270	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6231270G>A	ENST00000316375.2	+	2	313	c.263G>A	c.(262-264)gGa>gAa	p.G88E		NM_173525.2	NP_775796.2	Q8N5U0	CK042_HUMAN	chromosome 11 open reading frame 42	88										endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|soft_tissue(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGCAGGCAGGATCTGAGGGT	0.632000													20	38					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149884829	149884829	+	Silent	SNP	G	G	A	rs144646284	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149884829G>A	ENST00000369146.3	-	2	1054	c.564C>T	c.(562-564)ttC>ttT	p.F188F	SV2A_ENST00000369145.1_Silent_p.F188F	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	188					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TGGGCAGCACGAAGCCCACCA	0.582000													29	100					0	0	1	0	0
STOML3	161003	broad.mit.edu	37	13	39542580	39542580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39542580G>A	ENST00000379631.4	-	6	952	c.608C>T	c.(607-609)tCc>tTc	p.S203F	STOML3_ENST00000423210.1_Missense_Mutation_p.S194F	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	203						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GGCTGCCATGGATCTCTGCAA	0.557000													40	103					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18413795	18413795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18413795G>A	ENST00000440756.2	-	15	2960	c.2858C>T	c.(2857-2859)tCa>tTa	p.S953L	PSD3_ENST00000327040.8_Missense_Mutation_p.S951L|PSD3_ENST00000286485.8_Missense_Mutation_p.S417L|PSD3_ENST00000428502.2_Missense_Mutation_p.S280L|PSD3_ENST00000523619.1_Missense_Mutation_p.S886L			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	952					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GGGGGGATATGAGCGGTGCTC	0.488000													46	153					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43926898	43926898	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43926898G>A	ENST00000537548.1	-	8	1582	c.1338C>T	c.(1336-1338)gcC>gcT	p.A446A	MATN4_ENST00000372754.1_Silent_p.A487A|MATN4_ENST00000342716.4_Silent_p.A446A|MATN4_ENST00000372753.1_Silent_p.A297A|MATN4_ENST00000372751.4_Silent_p.A297A|MATN4_ENST00000353917.5_Silent_p.A364A|MATN4_ENST00000372756.1_Silent_p.A446A|MATN4_ENST00000360607.5_Silent_p.A405A			O95460	MATN4_HUMAN	matrilin 4	487	VWFA 2.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				GCACGTTAAGGGCACGGGGCC	0.662000													38	68					0	0	1	0	0
EGFL6	25975	broad.mit.edu	37	X	13613031	13613031	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:13613031G>A	ENST00000361306.1	+	3	521	c.264G>A	c.(262-264)ggG>ggA	p.G88G	EGFL6_ENST00000380602.3_Silent_p.G88G	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	88	EGF-like 1.				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						GATACACCGGGAAAACCTGCA	0.473000													16	14					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130222677	130222677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130222677C>T	ENST00000276211.5	+	12	1907	c.1562C>T	c.(1561-1563)cCc>cTc	p.P521L	ARHGAP36_ENST00000370921.1_Missense_Mutation_p.P385L|ARHGAP36_ENST00000370922.1_Missense_Mutation_p.P509L	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	521					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GGTAACCCTCCCATTCCGGAG	0.527000													20	12					0	0	1	0	0
MYC	4609	broad.mit.edu	37	8	128750684	128750684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:128750684C>T	ENST00000377970.2	+	2	731	c.221C>T	c.(220-222)cCg>cTg	p.P74L	MYC_ENST00000259523.6_Missense_Mutation_p.P59L|MYC_ENST00000524013.1_Missense_Mutation_p.P73L	NM_002467.4	NP_002458.2	P01106	MYC_HUMAN	v-myc avian myelocytomatosis viral oncogene homolog	59					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		CTGCCCACCCCGCCCCTGTCC	0.677000		3	"""A, T"""	"""IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"""	"""Burkitt lymphoma,  amplified in other cancers, B-CLL"""						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	35					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106917017	106917017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106917017G>A	ENST00000369701.3	+	10	1831	c.1604G>A	c.(1603-1605)aGa>aAa	p.R535K		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	535						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GTGGACCTGAGAGGAAGCCCA	0.557000													8	43					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55224579	55224579	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55224579C>T	ENST00000413439.1	+	0	1769																											TCTGAGACCTCTTGGTCCACC	0.622000													21	31					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885216	88885216	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:88885216G>A	ENST00000319675.3	-	1	1080	c.984C>T	c.(982-984)gtC>gtT	p.V328V		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	328										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						CGGCCGCCACGACTCCTTCTT	0.572000													20	57					0	0	1	0	0
RBFOX2	23543	broad.mit.edu	37	22	36142017	36142017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36142017G>A	ENST00000449924.2	-	12	1239	c.1051C>T	c.(1051-1053)Ccc>Tcc	p.P351S	RBFOX2_ENST00000359369.4_Silent_p.T337T|RBFOX2_ENST00000414461.2_Silent_p.T337T|RBFOX2_ENST00000397303.2_Missense_Mutation_p.P328S|RBFOX2_ENST00000416721.2_Missense_Mutation_p.P347S|RBFOX2_ENST00000405409.2_Silent_p.T334T|RBFOX2_ENST00000262829.7_Missense_Mutation_p.P329S|RBFOX2_ENST00000438146.2_Missense_Mutation_p.P422S			O43251	RFOX2_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 2	361	Ala-rich.				estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding			endometrium(4)|large_intestine(7)|lung(7)	18						GCATGGTAGGGGTCGGCTGTG	0.403000													122	376					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	75019754	75019754	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75019754T>A	ENST00000261978.4	-	5	1419	c.1033A>T	c.(1033-1035)Acg>Tcg	p.T345S	LTBP2_ENST00000556690.1_Missense_Mutation_p.T345S|CTD-2207P18.1_ENST00000554552.1_lincRNA|LTBP2_ENST00000557425.1_Intron	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	345					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		ATTTTCTCCGTGAGGTTCAGC	0.582000													6	30					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3319755	3319755	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3319755C>T	ENST00000336727.3	+	2	2762	c.1858C>T	c.(1858-1860)Cga>Tga	p.R620*	RGS12_ENST00000344733.5_Nonsense_Mutation_p.R620*|RGS12_ENST00000543385.1_Nonsense_Mutation_p.R620*|RGS12_ENST00000382788.3_Nonsense_Mutation_p.R620*	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	620						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCGAAATGTTCGAAAGACTAA	0.582000													62	117					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105774679	105774679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:105774679G>A	ENST00000393127.2	+	8	1471	c.1025G>A	c.(1024-1026)gGa>gAa	p.G342E	GRIA4_ENST00000428631.2_Missense_Mutation_p.G342E|GRIA4_ENST00000525187.1_Missense_Mutation_p.G342E|GRIA4_ENST00000282499.5_Missense_Mutation_p.G342E|GRIA4_ENST00000530497.1_Missense_Mutation_p.G342E|GRIA4_ENST00000393125.2_Missense_Mutation_p.G342E	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	342					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TGGGGCCAGGGAATTGACATG	0.408000													34	77					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36716041	36716041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36716041G>A	ENST00000244751.2	-	15	1599	c.975C>T	c.(973-975)acC>acT	p.T325T	CPNE5_ENST00000393189.2_Silent_p.T33T|CPNE5_ENST00000459703.1_5'UTR	NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	325										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						AGTTGATCTGGGTCCTAGAAG	0.582000													14	117					0	0	1	0	0
DPY19L3	147991	broad.mit.edu	37	19	32902290	32902290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:32902290C>T	ENST00000587077.1	+	3	406	c.249C>T	c.(247-249)ttC>ttT	p.F83F	DPY19L3_ENST00000342179.5_Intron|DPY19L3_ENST00000586987.1_Intron|DPY19L3_ENST00000392250.2_Intron			Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	0						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					TATGGAGTTTCTTTGACCATT	0.393000													48	87					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319378	21319378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:21319378G>A	ENST00000583088.1	+	3	1619	c.724G>A	c.(724-726)Gag>Aag	p.E242K	KCNJ12_ENST00000331718.5_Missense_Mutation_p.E242K	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CGAGGAGGGCGAGTACATCCC	0.607000										Prostate(3;0.18)			6	54					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77369707	77369707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77369707G>A	ENST00000282849.5	-	12	2223	c.1805C>T	c.(1804-1806)tCc>tTc	p.S602F		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	602	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						ACATGTCCGGGAACATTCTGA	0.567000													76	172					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50329519	50329519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50329519C>T	ENST00000338821.5	-	4	686	c.422G>A	c.(421-423)cGg>cAg	p.R141Q	ATP9A_ENST00000311637.5_Missense_Mutation_p.R126Q|ATP9A_ENST00000402822.1_Missense_Mutation_p.R141Q	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	141					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TGCTGTGAGCCGGCTGTAGAC	0.637000											OREG0026044	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	12					0	0	1	0	0
GPR19	2842	broad.mit.edu	37	12	12814457	12814457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:12814457G>A	ENST00000540510.1	-	2	1118	c.926C>T	c.(925-927)tCc>tTc	p.S309F	GPR19_ENST00000332427.2_Missense_Mutation_p.S309F			Q15760	GPR19_HUMAN	G protein-coupled receptor 19	309						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		GAAAACAAGGGAACTTTTCTT	0.388000													25	64					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31593601	31593601	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31593601C>T	ENST00000376033.2	+	8	1026	c.792C>T	c.(790-792)ccC>ccT	p.P264P	PRRC2A_ENST00000376007.4_Silent_p.P264P|PRRC2A_ENST00000469577.1_3'UTR	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	264	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						TCCCTCCGCCCTATGGACCCC	0.577000													16	74					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353842	77353842	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77353842G>A	ENST00000282849.5	-	16	2854	c.2436C>T	c.(2434-2436)ttC>ttT	p.F812F		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	812	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CAGCGAAGGGGAACTCCCCAG	0.572000													13	78					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1023983	1023983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1023983C>T	ENST00000421673.2	-	25	3396	c.3346G>A	c.(3346-3348)Ggt>Agt	p.G1116S		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1116					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACGCACACACCCTTGTCCAGA	0.682000													12	27					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63477198	63477198	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:63477198C>T	ENST00000536984.2	+	3	1163	c.469C>T	c.(469-471)Cca>Tca	p.P157S	CDH7_ENST00000397968.2_Missense_Mutation_p.P157S|CDH7_ENST00000323011.3_Missense_Mutation_p.P157S			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	157	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TTTGGATGGCCCATACACGGC	0.463000													57	133					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77944601	77944601	+	Missense_Mutation	SNP	C	C	T	rs140615876	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77944601C>T	ENST00000493585.1	-	5	858	c.836G>A	c.(835-837)cGg>cAg	p.R279Q	ISM2_ENST00000429906.1_Silent_p.T313T|ISM2_ENST00000393684.3_Silent_p.T306T|ISM2_ENST00000412904.1_Silent_p.T313T|ISM2_ENST00000342219.4_Silent_p.T394T	NM_182509.3	NP_872315.2	Q6H9L7	ISM2_HUMAN	isthmin 2	0						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						CATGCATGTCCGTAGCATTGC	0.607000													24	127					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6916364	6916364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6916364G>A	ENST00000312053.4	+	12	1442	c.1405G>A	c.(1405-1407)Gaa>Aaa	p.E469K	EMR1_ENST00000450315.3_Missense_Mutation_p.E292K|EMR1_ENST00000381404.4_Missense_Mutation_p.E417K|EMR1_ENST00000250572.8_Missense_Mutation_p.E469K|EMR1_ENST00000381407.5_Missense_Mutation_p.E328K	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	469	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CACAATTGAGGAATCTGAATC	0.438000													38	111					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54849621	54849621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:54849621C>T	ENST00000333896.5	+	8	1407	c.1022C>T	c.(1021-1023)cCc>cTc	p.P341L	SPTBN1_ENST00000356805.4_Missense_Mutation_p.P354L	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	354					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GAGAAACCACCCAAGTAAGAT	0.413000													8	108					0	0	1	0	0
ZNF558	148156	broad.mit.edu	37	19	8922431	8922431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8922431G>A	ENST00000601372.1	-	10	1446	c.735C>T	c.(733-735)ttC>ttT	p.F245F	ZNF558_ENST00000301475.1_Silent_p.F245F|ZNF558_ENST00000444186.2_Silent_p.F174F			Q96NG5	ZN558_HUMAN	zinc finger protein 558	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						AACTGGTGCGGAAAACGTGAA	0.443000													29	52					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2375858	2375858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2375858C>T	ENST00000202625.2	+	3	261	c.200C>T	c.(199-201)gCc>gTc	p.A67V	TGM6_ENST00000381423.1_Missense_Mutation_p.A67V|TGM6_ENST00000477505.1_Intron	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	67					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	GCTTCTGAGGCCCTCCACACC	0.582000													9	27					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900161	151900161	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151900161C>T	ENST00000393900.3	-	3	993	c.640G>A	c.(640-642)Gac>Aac	p.D214N	MAGEA12_ENST00000393869.3_Missense_Mutation_p.D214N|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Missense_Mutation_p.D214N	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	214	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGCACAGTCGCCCTCTTTT	0.582000													87	72					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89346601	89346601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89346601G>A	ENST00000301030.4	-	9	6809	c.6349C>T	c.(6349-6351)Ccg>Tcg	p.P2117S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P2117S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2117	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CAGGGCACCGGCTCCACCTGG	0.697000													3	16					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1418759	1418759	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:1418759G>A	ENST00000446702.2	+	17	2793	c.2166_splice	c.e17+1	p.E722_splice	CNTN6_ENST00000539053.1_Splice_Site_p.E650_splice|CNTN6_ENST00000350110.2_Splice_Site_p.E722_splice			Q9UQ52	CNTN6_HUMAN	contactin 6	722	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TTACGTGGGAGGTAATTTTCT	0.398000													43	99					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54578136	54578136	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54578136C>T	ENST00000336470.4	+	11	1138	c.999C>T	c.(997-999)acC>acT	p.T333T	GNL3L_ENST00000360845.2_Silent_p.T333T	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	333					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						ACCCTGTGACCCCAGTGGAGA	0.627000													6	33					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049038	70049038	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70049038G>A	ENST00000330891.5	-	10	1882	c.1656C>T	c.(1654-1656)ccC>ccT	p.P552P	BEST3_ENST00000488961.1_Silent_p.P339P|BEST3_ENST00000553096.1_Silent_p.P446P|BEST3_ENST00000331471.4_Intron	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	552						chloride channel complex|plasma membrane	chloride channel activity	p.P552P(1)		cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CCTTCTCTGAGGGAGACAGGA	0.542000													19	80					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3329159	3329159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3329159G>A	ENST00000378398.3	+	10	2483	c.2401G>A	c.(2401-2403)Gag>Aag	p.E801K	PRDM16_ENST00000378391.2_Missense_Mutation_p.E800K|PRDM16_ENST00000270722.5_Missense_Mutation_p.E800K|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Missense_Mutation_p.E800K|PRDM16_ENST00000441472.2_Missense_Mutation_p.E800K|PRDM16_ENST00000514189.1_Missense_Mutation_p.E801K|PRDM16_ENST00000511072.1_Missense_Mutation_p.E801K			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	800	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ATCCGGCGAGGAGCAGCCGCT	0.692000			T	EVI1	"""MDS, AML"""								7	21					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	71012625	71012625	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:71012625C>T	ENST00000357250.6	-	1	161	c.3G>A	c.(1-3)atG>atA	p.M1I	COL9A1_ENST00000370496.3_Start_Codon_SNP_p.M1I	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	1					axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AGCAGGTCTTCATTTTCCCAG	0.502000													74	120					0	0	1	0	0
WBP11	51729	broad.mit.edu	37	12	14942001	14942001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14942001G>A	ENST00000261167.2	-	11	1609	c.1376C>T	c.(1375-1377)cCt>cTt	p.P459L	WBP11_ENST00000537574.1_Missense_Mutation_p.P425L	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	459	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						TGGTCCTGGAGGTAAAAGTCG	0.597000													7	25					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008530	120008530	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120008530G>A	ENST00000341846.5	-	1	631	c.210C>T	c.(208-210)ttC>ttT	p.F70F		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	70					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CATTGCCCGCGAACAGGGCGC	0.622000													36	201					0	0	1	0	0
NUFIP1	26747	broad.mit.edu	37	13	45563333	45563333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:45563333G>A	ENST00000379161.4	-	1	285	c.239C>T	c.(238-240)cCc>cTc	p.P80L	RP11-321C24.1_ENST00000437748.2_lincRNA	NM_012345.2	NP_036477.2	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein interacting protein 1	80	Pro-rich.				box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(4)|skin(3)	18		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		GGCGTCGAAGGGGGGCGGAGC	0.662000													16	24					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87735635	87735635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:87735635C>T	ENST00000436978.1	+	48	7884	c.7404C>T	c.(7402-7404)gtC>gtT	p.V2468V	PTPN13_ENST00000316707.6_Silent_p.V2272V|PTPN13_ENST00000411767.2_Silent_p.V2463V|PTPN13_ENST00000511467.1_Silent_p.V2468V|PTPN13_ENST00000427191.2_Silent_p.V2444V	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2463						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		GCTATCAAGTCATCCTTTATG	0.348000													6	54					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154860056	154860056	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:154860056C>T	ENST00000460393.1	+	12	1245	c.1125C>T	c.(1123-1125)ttC>ttT	p.F375F	MME_ENST00000360490.2_Silent_p.F375F|MME_ENST00000462745.1_Silent_p.F375F|MME_ENST00000492661.1_Silent_p.F375F|MME_ENST00000493237.1_Silent_p.F375F	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	375					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CCTGGAGATTCATAATGGATC	0.398000													37	104					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23237025	23237025	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23237025C>T	ENST00000400191.3	+	14	2671	c.2653C>T	c.(2653-2655)Cgc>Tgc	p.R885C	EPHB2_ENST00000374627.1_Missense_Mutation_p.R880C|EPHB2_ENST00000374630.3_Missense_Mutation_p.R885C|EPHB2_ENST00000374632.3_Missense_Mutation_p.R886C	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	885					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CAAGATGATCCGCAATCCCAA	0.637000													12	51					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25488690	25488690	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25488690C>T	ENST00000453082.2	+	0	2318					NR_003343.1																						ACCCTGGTCTCCTGCACTAGC	0.587000													43	111					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177690298	177690298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:177690298C>T	ENST00000390654.3	-	9	907	c.550G>A	c.(550-552)Ggg>Agg	p.G184R	COL23A1_ENST00000407622.1_Missense_Mutation_p.G148R	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	184	Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CCCGGAGGCCCAGCAGCTCCA	0.672000													9	21					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21523896	21523896	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21523896C>T	ENST00000313654.9	+	69	9412	c.9171C>T	c.(9169-9171)atC>atT	p.I3057I	LAMA3_ENST00000587184.1_Silent_p.I1392I|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000269217.6_Silent_p.I1448I|LAMA3_ENST00000399516.3_Silent_p.I3001I	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	3057	Laminin G-like 4.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATTGAGGATCAAAAGCAAGG	0.468000													11	62					0	0	1	0	0
POLR3B	55703	broad.mit.edu	37	12	106824192	106824192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:106824192C>T	ENST00000228347.4	+	14	1627	c.1405C>T	c.(1405-1407)Cgc>Tgc	p.R469C	POLR3B_ENST00000539066.1_Missense_Mutation_p.R411C	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	469					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						GAGTGGTCCTCGCTCCCTCCA	0.493000													22	107					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45028282	45028282	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45028282G>A	ENST00000454753.1	-	0	487							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				TGCAATGGAGGGTTTGGCCAG	0.527000													11	52					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32907432	32907432	+	Missense_Mutation	SNP	C	C	T	rs80358469		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32907432C>T	ENST00000544455.1	+	10	2044	c.1817C>T	c.(1816-1818)cCg>cTg	p.P606L	BRCA2_ENST00000380152.3_Missense_Mutation_p.P606L	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	606					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAAAAATACCGAAAGACCAA	0.318000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			18	57					0	0	1	0	0
TNFSF10	8743	broad.mit.edu	37	3	172241118	172241118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172241118G>A	ENST00000241261.2	-	1	179	c.57C>T	c.(55-57)atC>atT	p.I19I	TNFSF10_ENST00000420541.2_Silent_p.I19I	NM_003810.3	NP_003801.1	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily, member 10	19					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			breast(2)|cervix(1)|large_intestine(1)|lung(6)|ovary(1)|skin(4)	15	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TGAAGATCACGATCAGCACGC	0.562000													29	81					0	0	1	0	0
CLDN6	9074	broad.mit.edu	37	16	3065685	3065685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3065685G>A	ENST00000396925.1	-	3	766	c.338C>T	c.(337-339)tCc>tTc	p.S113F	CLDN6_ENST00000328796.4_Missense_Mutation_p.S113F|CLDN6_ENST00000572154.1_Intron			P56747	CLD6_HUMAN	claudin 6	113					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GCGGGCCTTGGAATCCTTCTC	0.612000													15	44					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241808770	241808770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241808770G>A	ENST00000307503.3	+	2	736	c.349G>A	c.(349-351)Gag>Aag	p.E117K		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	117					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GGACATCGGGGAGCGCATAGG	0.657000													5	58					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60107264	60107264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60107264G>A	ENST00000397786.2	-	7	1196	c.1120C>T	c.(1120-1122)Cat>Tat	p.H374Y		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	374					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TCCACCACATGATTTGCTAAT	0.373000													20	101					0	0	1	0	0
MMAB	326625	broad.mit.edu	37	12	110009504	110009504	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110009504G>A	ENST00000545712.2	-	2	539	c.146C>T	c.(145-147)tCc>tTc	p.S49F	MMAB_ENST00000266839.5_5'UTR|MMAB_ENST00000540016.1_Intron	NM_052845.3	NP_443077.1	Q96EY8	MMAB_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblB type	49					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|urinary_tract(1)	6					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGTCTTCGAGGAAGGCTGTGG	0.498000													9	36					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20966148	20966148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20966148G>A	ENST00000261383.3	-	55	11057	c.11058C>T	c.(11056-11058)aaC>aaT	p.N3686N	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3686	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GGGGGCCGAAGTTTCTTCTCT	0.488000													34	127					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23792369	23792369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23792369C>T	ENST00000354639.3	+	9	1446	c.982C>T	c.(982-984)Cac>Tac	p.H328Y	STK31_ENST00000433467.2_Missense_Mutation_p.H351Y|STK31_ENST00000355870.3_Missense_Mutation_p.H351Y|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Missense_Mutation_p.H328Y	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	351							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTTGACTAACCACTTAGAATA	0.353000													18	58					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123987394	123987394	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123987394G>A	ENST00000369005.1	+	14	8107	c.7767G>A	c.(7765-7767)gcG>gcA	p.A2589A	TACC2_ENST00000334433.3_Silent_p.A2589A|TACC2_ENST00000358010.1_Silent_p.A735A|TACC2_ENST00000369004.3_Silent_p.A679A|TACC2_ENST00000513429.1_Silent_p.A735A|TACC2_ENST00000369001.1_Silent_p.A293A|TACC2_ENST00000369000.1_Silent_p.A289A|TACC2_ENST00000515603.1_Silent_p.A2544A|TACC2_ENST00000360561.3_Silent_p.A667A|TACC2_ENST00000368999.1_Silent_p.A679A|TACC2_ENST00000260733.3_Silent_p.A667A|TACC2_ENST00000515273.1_Silent_p.A2593A|TACC2_ENST00000453444.2_Silent_p.A2593A	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2589						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACACTGCTGCGAAAAACCAGC	0.522000													52	101					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1268745	1268745	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1268745G>A	ENST00000310581.5	-	9	2529	c.2472C>T	c.(2470-2472)tcC>tcT	p.S824S	TERT_ENST00000296820.5_Silent_p.L764L|TERT_ENST00000508104.2_Silent_p.L764L|TERT_ENST00000334602.6_Silent_p.S824S	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	824	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACTGGACGTAGGACCTGGGGC	0.602000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				10	41					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44598104	44598104	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44598104G>A	ENST00000322927.2	-	3	528	c.428C>T	c.(427-429)cCc>cTc	p.P143L	ZNF335_ENST00000426788.1_Intron	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GATGAGGTCGGGCCCGATGGT	0.622000													4	31					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53269385	53269385	+	Missense_Mutation	SNP	G	G	A	rs137948996	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53269385G>A	ENST00000338230.3	-	3	1891	c.1624C>T	c.(1624-1626)Cat>Tat	p.H542Y		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	542					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CGATGGCAATGAAGGTATGAC	0.458000													101	262					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61843366	61843366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61843366C>T	ENST00000280772.1	-	33	4275	c.4084G>A	c.(4084-4086)Gga>Aga	p.G1362R	ANK3_ENST00000503366.1_Missense_Mutation_p.G1363R|ANK3_ENST00000373827.2_Missense_Mutation_p.G1356R|ANK3_ENST00000355288.2_Missense_Mutation_p.G496R	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1362					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATAGGTTTTCCTTCCAGAACC	0.294000													22	63					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100831085	100831085	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:100831085G>A	ENST00000358544.2	+	47	8776	c.8665G>A	c.(8665-8667)Gac>Aac	p.D2889N	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.D2864N	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2889					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CATAGAACCTGACCTTGTACA	0.378000													23	72					0	0	1	0	0
GLB1L	79411	broad.mit.edu	37	2	220104315	220104315	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220104315C>T	ENST00000295759.7	-	9	1183	c.870G>A	c.(868-870)gaG>gaA	p.E290E	GLB1L_ENST00000356283.3_Silent_p.E200E|GLB1L_ENST00000497855.1_5'UTR|GLB1L_ENST00000392089.2_Silent_p.E290E|GLB1L_ENST00000409640.1_Silent_p.E200E			Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like	290					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGAGCATGTTCTCTAGTCCTT	0.478000													73	168					0	0	1	0	0
MRPL44	65080	broad.mit.edu	37	2	224824624	224824624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:224824624C>T	ENST00000258383.3	+	2	622	c.553C>T	c.(553-555)Cca>Tca	p.P185S		NM_022915.3	NP_075066.1	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44	185	RNase III.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGAAGAATTCCCAGTGCCCCC	0.483000													45	101					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57982295	57982295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57982295C>T	ENST00000309433.6	+	1	79	c.79C>T	c.(79-81)Ctc>Ttc	p.L27F		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				TGAATTCATTCTCCTGGGATT	0.413000													53	125					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54971043	54971043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54971043C>T	ENST00000243052.3	+	15	1978	c.1542C>T	c.(1540-1542)tcC>tcT	p.S514S	PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Silent_p.S473S|PPP1R1A_ENST00000547431.1_3'UTR|PDE1B_ENST00000550620.1_Silent_p.S494S	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	514					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						ACGAGCTGTCCCCCTGTGAAG	0.557000													37	149					0	0	1	0	0
AFM	173	broad.mit.edu	37	4	74354374	74354374	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74354374C>T	ENST00000226355.3	+	7	834	c.741C>T	c.(739-741)ttC>ttT	p.F247F		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	247	Albumin 2.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCAAAAATTCCCCAAGATTG	0.363000													23	84					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128455945	128455945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128455945C>T	ENST00000297788.4	+	16	3690	c.3323C>T	c.(3322-3324)cCc>cTc	p.P1108L	CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000471729.1_3'UTR|CCDC136_ENST00000487361.1_Intron|CCDC136_ENST00000464832.1_Intron	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	1108	Glu-rich.					integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						CTTGAAAGTCCCGAAGAAAAT	0.493000													7	27					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51096346	51096346	+	Missense_Mutation	SNP	G	G	A	rs138592316		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:51096346G>A	ENST00000395542.2	-	12	2877	c.2693C>T	c.(2692-2694)cCc>cTc	p.P898L	COBL_ENST00000265136.7_Missense_Mutation_p.P816L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	816										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CTTCTGCTGGGGCGATATTGG	0.657000													11	52					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402960	248402960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248402960C>T	ENST00000306687.1	+	1	730	c.730C>T	c.(730-732)Cac>Tac	p.H244Y		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTGCTCCTCCCACCTGTCTGT	0.517000													16	64					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327956	57327956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57327956C>T	ENST00000326441.9	-	10	2217	c.1854G>A	c.(1852-1854)caG>caA	p.Q618Q	PEG3_ENST00000423103.2_Silent_p.Q618Q|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Silent_p.Q492Q|PEG3_ENST00000598410.1_Silent_p.Q494Q|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	618					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CATACATTTTCTGAAACTCAT	0.443000													15	38					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	138011723	138011723	+	Missense_Mutation	SNP	C	C	T	rs1049289		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138011723C>T	ENST00000252854.4	+	6	1290	c.1103C>T	c.(1102-1104)tCc>tTc	p.S368F	OLFM1_ENST00000371793.3_Missense_Mutation_p.S386F|OLFM1_ENST00000371796.3_Missense_Mutation_p.S359F	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	386	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		GACCCCGTGTCCCTGCAGACC	0.637000													16	35					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	134973999	134973999	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134973999G>A	ENST00000304613.3	+	1	49	c.28G>A	c.(28-30)Gat>Aat	p.D10N	KNDC1_ENST00000368572.2_Missense_Mutation_p.D10N			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	10					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGCCGCGGCGGATCTTTACGA	0.756000													5	12					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85967484	85967484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:85967484C>T	ENST00000263360.6	+	5	1168	c.482C>T	c.(481-483)cCt>cTt	p.P161L	EED_ENST00000528180.1_Missense_Mutation_p.P161L|EED_ENST00000327320.4_Missense_Mutation_p.P161L|EED_ENST00000351625.6_Missense_Mutation_p.P161L	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	161	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				ACGAGCCATCCTCTGCTGGCT	0.358000													10	74					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33134586	33134586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33134586C>T	ENST00000341947.2	-	59	4476	c.4249G>A	c.(4249-4251)Gga>Aga	p.G1417R	COL11A2_ENST00000357486.1_Missense_Mutation_p.G1396R|COL11A2_ENST00000361917.1_Missense_Mutation_p.G1310R|COL11A2_ENST00000374708.4_Missense_Mutation_p.G1331R|COL11A2_ENST00000395197.1_Missense_Mutation_p.G1357R|COL11A2_ENST00000374712.1_Missense_Mutation_p.G1336R|COL11A2_ENST00000374713.1_Missense_Mutation_p.G1370R|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374714.1_Missense_Mutation_p.G1391R	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1417	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCAATCAGTCCAATGAGACCT	0.607000													4	39					0	0	1	0	0
XRRA1	143570	broad.mit.edu	37	11	74559185	74559185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74559185C>T	ENST00000340360.6	-	15	2010	c.1679G>A	c.(1678-1680)aGc>aAc	p.S560N	XRRA1_ENST00000527087.1_Missense_Mutation_p.S473N|XRRA1_ENST00000321448.8_Missense_Mutation_p.S285N	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	560					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						GGACTCTGTGCTCTTGGAGTC	0.577000													7	29					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52200481	52200481	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52200481G>A	ENST00000354534.5	+	27	5389	c.5211G>A	c.(5209-5211)ggG>ggA	p.G1737G	SCN8A_ENST00000545061.1_Silent_p.G1696G	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1737					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GAGATTGTGGGAACCCCTCAG	0.512000													25	52					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456123	5456123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5456123C>T	ENST00000222033.4	+	1	698	c.621C>T	c.(619-621)atC>atT	p.I207I		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	207	PA.					integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GGGGCCAGATCGCCATCCCCT	0.682000													40	89					0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230010	56230010	+	Silent	SNP	G	G	A	rs145474756	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56230010G>A	ENST00000279791.1	-	1	867	c.868C>T	c.(868-870)Ctg>Ttg	p.L290L		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					TTATTTCTCAGACTGTAGATC	0.403000													37	96					0	0	1	0	0
ENAH	55740	broad.mit.edu	37	1	225702558	225702558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:225702558G>A	ENST00000366844.2	-	7	1409	c.958C>T	c.(958-960)Cca>Tca	p.P320S	ENAH_ENST00000284563.6_Missense_Mutation_p.P567S|ENAH_ENST00000366843.2_Missense_Mutation_p.P320S	NM_001008493.1	NP_001008493.1	Q8N8S7	ENAH_HUMAN	enabled homolog (Drosophila)	320	Pro-rich.				axon guidance|intracellular transport|T cell receptor signaling pathway	cytosol|filopodium|focal adhesion|lamellipodium|synapse	actin binding|SH3 domain binding|WW domain binding			NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.19)		ggccctggtgggagtggtgga	0.592000													13	36					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803521	185803521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185803521C>T	ENST00000302277.6	+	4	3992	c.3398C>T	c.(3397-3399)tCc>tTc	p.S1133F		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1133						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CAGTTTCTTTCCCAAATCCCA	0.542000													37	79					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169572341	169572341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169572341C>T	ENST00000263686.6	-	10	1665	c.1628G>A	c.(1627-1629)gGa>gAa	p.G543E	SELP_ENST00000367792.2_Intron|SELP_ENST00000458599.2_Intron|SELP_ENST00000367791.2_Missense_Mutation_p.G419E|SELP_ENST00000367788.2_Missense_Mutation_p.G481E|SELP_ENST00000367786.2_Missense_Mutation_p.G481E|SELP_ENST00000367794.2_Missense_Mutation_p.G481E|SELP_ENST00000367793.2_Missense_Mutation_p.G481E	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	543	Sushi 6.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CAAAGAATATCCCTCGTCACA	0.473000													42	84					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129905716	129905716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129905716G>A	ENST00000368654.3	-	13	4763	c.4388C>T	c.(4387-4389)cCc>cTc	p.P1463L	MKI67_ENST00000368653.3_Missense_Mutation_p.P1103L	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1463	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTCTTCTAGGGGTTGGGCCTT	0.493000													65	256					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619443	57619443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57619443C>T	ENST00000349394.5	+	2	1015	c.840C>T	c.(838-840)ttC>ttT	p.F280F		NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	280	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						TCTGTATCTTCGTCTCTTTCC	0.577000													17	69					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35974126	35974126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:35974126C>T	ENST00000297866.5	+	8	1289	c.1223C>T	c.(1222-1224)cCt>cTt	p.P408L		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	408										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						ACAGGACTTCCTGTTTTACTA	0.373000													35	61					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907749	12907749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12907749G>A	ENST00000317869.6	-	2	619	c.394C>T	c.(394-396)Cct>Tct	p.P132S		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						GGAGGAGGAGGAGGTACACGT	0.498000													34	209					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541169	55541169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55541169C>T	ENST00000220676.1	+	4	4875	c.4727C>T	c.(4726-4728)tCt>tTt	p.S1576F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1576					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TCAGAGTCCTCTCCTGATTTA	0.383000													17	69					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075484	9075484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9075484C>T	ENST00000397910.4	-	3	12165	c.11962G>A	c.(11962-11964)Gaa>Aaa	p.E3988K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3990	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATTGCTTGTTCCCTGGTGGAG	0.488000													15	35					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55238216	55238216	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55238216C>T	ENST00000344576.2	+	16	2342	c.2097C>T	c.(2095-2097)atC>atT	p.I699I	EGFR_ENST00000454757.2_Intron|EGFR_ENST00000275493.2_Intron|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_Intron	NM_201284.1	NP_958441.1	P00533	EGFR_HUMAN	epidermal growth factor receptor	0	Important for dimerization, phosphorylation and activation.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTGTGATCATCACGGCCTCCT	0.597000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			21	89					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819612	50819612	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50819612C>T	ENST00000374115.3	+	1	1266	c.826C>T	c.(826-828)Ctg>Ttg	p.L276L	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	276					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						TCGGGCCAACCTGCCAGTGGG	0.652000													31	56					0	0	1	0	0
FKBP9L	360132	broad.mit.edu	37	7	55755518	55755518	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55755518C>T	ENST00000455909.1	-	0	488					NR_027340.1|NR_027342.1				FK506 binding protein 9-like											endometrium(1)|kidney(1)|lung(3)	5						TGATCACTGTCCGTTTCTCGC	0.517000													17	59					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92647599	92647599	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:92647599C>G	ENST00000318445.6	+	4	1050	c.836C>G	c.(835-837)tCc>tGc	p.S279C	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.S279C|SLCO3A1_ENST00000555549.1_3'UTR	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	279					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TTCTTCTCTTCCCTCTTGATG	0.587000													13	233					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997406	115997406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:115997406G>A	ENST00000264363.2	-	2	1465	c.787C>T	c.(787-789)Cat>Tat	p.H263Y		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	263	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATTCCATCATGAAGCCCCAGA	0.438000													48	166					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228467731	228467731	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228467731G>A	ENST00000366707.4	+	0	7650				OBSCN_ENST00000422127.1_Missense_Mutation_p.G2536S|OBSCN_ENST00000359599.6_Missense_Mutation_p.G1383S|OBSCN_ENST00000284548.11_Missense_Mutation_p.G2536S|OBSCN_ENST00000366709.4_De_novo_Start_OutOfFrame|OBSCN_ENST00000570156.2_Missense_Mutation_p.G2965S			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGCTGATGCTGGTGTCTACCG	0.612000													4	9					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	62029974	62029974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:62029974G>A	ENST00000280772.1	-	5	619	c.428C>T	c.(427-429)cCa>cTa	p.P143L	ANK3_ENST00000503366.1_Missense_Mutation_p.P126L|ANK3_ENST00000373827.2_Missense_Mutation_p.P137L	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	143					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CATATACAATGGCGTGAAACC	0.403000													12	36					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51497470	51497470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51497470C>T	ENST00000371117.3	-	65	11833	c.11558G>A	c.(11557-11559)aGg>aAg	p.R3853K		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3853					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CTTCTCCTTCCTAGTCACAGG	0.478000													24	81					0	0	1	0	0
GYS1	2997	broad.mit.edu	37	19	49490508	49490508	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49490508G>A	ENST00000323798.3	-	3	631	c.435C>T	c.(433-435)gaC>gaT	p.D145D	GYS1_ENST00000540532.1_Silent_p.D65D|GYS1_ENST00000541188.1_Silent_p.D65D|GYS1_ENST00000544287.1_Intron|GYS1_ENST00000457974.1_5'UTR|GYS1_ENST00000263276.6_Intron	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	145					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TGGCCTCGCGGTCGTACCACG	0.607000													14	28					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101480449	101480449	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101480449G>A	ENST00000392979.3	+	16	1804	c.1443G>A	c.(1441-1443)gtG>gtA	p.V481V	ANO4_ENST00000550015.1_Silent_p.V36V|ANO4_ENST00000392977.3_Silent_p.V516V|ANO4_ENST00000299222.9_Silent_p.V36V	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	516						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TCTGCGTGGTGATTGCTGCCG	0.502000										HNSCC(74;0.22)			90	203					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186944252	186944252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186944252C>T	ENST00000337774.5	-	12	1887	c.1498G>A	c.(1498-1500)Gat>Aat	p.D500N		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	500	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		AGGGTCGGATCTTCCGGATCG	0.577000													3	15					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55690819	55690819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55690819C>T	ENST00000379906.2	+	1	468	c.213C>T	c.(211-213)ggC>ggT	p.G71G	SLC6A2_ENST00000566163.1_Silent_p.G71G|SLC6A2_ENST00000414754.3_Silent_p.G71G|SLC6A2_ENST00000561820.1_Silent_p.G71G|SLC6A2_ENST00000568943.1_Silent_p.G71G|SLC6A2_ENST00000219833.8_Silent_p.G71G	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	71					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CCGTAGTCGGCTTCGCAGTGG	0.672000													25	87					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526305	176526305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176526305C>T	ENST00000367662.3	+	2	2011	c.847C>T	c.(847-849)Ccc>Tcc	p.P283S	PAPPA2_ENST00000367661.3_Missense_Mutation_p.P283S	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	283					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGCTGAGATTCCCCGGGAGGC	0.567000													11	26					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54435228	54435228	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54435228G>A	ENST00000537900.1	+	2	2997	c.2997G>A	c.(2995-2997)gtG>gtA	p.V999V	UNC13C_ENST00000260323.11_Silent_p.V999V|UNC13C_ENST00000545554.1_Intron			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	999					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCAGTTCTGTGGATGAAAAGG	0.328000													23	78					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51400016	51400016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51400016C>T	ENST00000266037.9	+	49	5227	c.5204C>T	c.(5203-5205)tCg>tTg	p.S1735L		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1735	Ser-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GTTCTGTCCTCGTCCCAGGCA	0.562000													17	47					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39227429	39227429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39227429C>T	ENST00000340369.3	-	2	3736	c.3508G>A	c.(3508-3510)Gag>Aag	p.E1170K	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1170							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AGGGCAGTCTCCCTGTGCCTT	0.642000													12	29					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222429004	222429004	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:222429004G>A	ENST00000281821.2	-	3	311	c.270C>T	c.(268-270)acC>acT	p.T90T	EPHA4_ENST00000409938.1_Silent_p.T90T|EPHA4_ENST00000409854.1_Silent_p.T90T|EPHA4_ENST00000392071.4_Silent_p.T39T	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	90						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CCCCTTCTCGGGTGATCCAAT	0.468000													14	171					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119738993	119738993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:119738993G>A	ENST00000541757.1	+	10	921	c.541G>A	c.(541-543)Ggg>Agg	p.G181R	MARCO_ENST00000327097.4_Missense_Mutation_p.G259R			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	259	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGGAAGCAAAGGGGACAGGGG	0.562000													10	24					0	0	1	0	0
TRBV25-1	28562	broad.mit.edu	37	7	142378989	142378989	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142378989C>T	ENST00000390398.3	+	0	294																											TCAACAGTCTCCAGAATAAGG	0.483000													28	71					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44108899	44108899	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:44108899G>A	ENST00000262419.6	-	15	3731	c.3261C>T	c.(3259-3261)ccC>ccT	p.P1087P	KANSL1_ENST00000575318.1_Silent_p.P1023P|KANSL1_ENST00000432791.1_Silent_p.P1087P|KANSL1_ENST00000572904.1_Silent_p.P1087P|KANSL1_ENST00000393476.3_Silent_p.P381P|KANSL1_ENST00000574590.1_Silent_p.P1087P	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	1087						MLL1 complex	protein binding										GACTCTTGAGGGGGACAATGG	0.617000													9	19					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10870427	10870427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10870427C>T	ENST00000314646.5	+	2	339	c.175C>T	c.(175-177)Cgc>Tgc	p.R59C	DNM2_ENST00000389253.4_Missense_Mutation_p.R59C|DNM2_ENST00000585892.1_Missense_Mutation_p.R59C|DNM2_ENST00000408974.4_Missense_Mutation_p.R59C|DNM2_ENST00000359692.6_Missense_Mutation_p.R59C|DNM2_ENST00000355667.6_Missense_Mutation_p.R59C			P50570	DYN2_HUMAN	dynamin 2	59					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTTCCTTCCCCGCGGTTCAGG	0.567000			"""F, N, Splice, Mis, O"""		ETP ALL								47	236					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141675040	141675040	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:141675040G>A	ENST00000522684.1	-	31	3151	c.2922C>T	c.(2920-2922)ctC>ctT	p.L974L	PTK2_ENST00000430260.2_Silent_p.L284L|PTK2_ENST00000517887.1_Silent_p.L1018L|PTK2_ENST00000340930.3_Silent_p.L987L|PTK2_ENST00000519465.1_Silent_p.L602L|PTK2_ENST00000538769.1_Silent_p.L642L|PTK2_ENST00000535192.1_Silent_p.L928L|PTK2_ENST00000521059.1_Silent_p.L974L|PTK2_ENST00000395218.2_Silent_p.L987L|PTK2_ENST00000519419.1_Silent_p.L1018L|PTK2_ENST00000517712.1_Silent_p.L37L	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	974	Interaction with RGNEF (By similarity).|Interaction with TGFB1I1.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TGGCTGGTAGGAGGGGAATGG	0.542000													11	23					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23776524	23776524	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23776524G>A	ENST00000354639.3	+	8	1239	c.773_splice	c.e8-1	p.E259_splice	STK31_ENST00000433467.2_Splice_Site_p.E282_splice|STK31_ENST00000355870.3_Splice_Site_p.E282_splice|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Splice_Site_p.E259_splice	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	282							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TTTTTATAGGGAAAGTTTGGC	0.323000													16	48					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90455056	90455056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:90455056G>A	ENST00000369393.3	-	29	4229	c.4114C>T	c.(4114-4116)Ctc>Ttc	p.L1372F	MDN1_ENST00000428876.1_Missense_Mutation_p.L1372F			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1372					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGCATCGCGAGTCTCCGCATG	0.453000													34	53					0	0	1	0	0
PRSS50	29122	broad.mit.edu	37	3	46753846	46753846	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46753846G>A	ENST00000460241.1	-	11	2718	c.1048C>T	c.(1048-1050)Caa>Taa	p.Q350*	PRSS50_ENST00000315170.7_Nonsense_Mutation_p.Q350*			Q9UI38	TSP50_HUMAN	protease, serine, 50	350	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						ATCCAGTGTTGGTAGGAGGAG	0.657000													6	25					0	0	1	0	0
RBPJ	3516	broad.mit.edu	37	4	26387991	26387991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:26387991C>T	ENST00000342320.4	+	2	210	c.34C>T	c.(34-36)Cct>Tct	p.P12S	RBPJ_ENST00000348160.4_Missense_Mutation_p.P13S|RBPJ_ENST00000504907.1_Missense_Mutation_p.P12S|RBPJ_ENST00000342295.1_Missense_Mutation_p.P26S|RBPJ_ENST00000361572.6_Missense_Mutation_p.P26S|RBPJ_ENST00000345843.3_Missense_Mutation_p.P11S|RBPJ_ENST00000511401.1_3'UTR|RBPJ_ENST00000355476.3_Missense_Mutation_p.P12S|RBPJ_ENST00000507561.1_5'UTR			Q06330	SUH_HUMAN	recombination signal binding protein for immunoglobulin kappa J region	26					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)	15		Breast(46;0.0503)				TGGTGAGCGGCCTCCACCTAA	0.279000													10	43					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1396269	1396269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1396269G>A	ENST00000324385.5	+	25	2663	c.2505G>A	c.(2503-2505)ggG>ggA	p.G835G	BAIAP3_ENST00000568887.1_Silent_p.G772G|BAIAP3_ENST00000562208.1_Silent_p.G777G|BAIAP3_ENST00000421665.2_Silent_p.G764G|BAIAP3_ENST00000397488.2_Silent_p.G817G|BAIAP3_ENST00000397489.1_Silent_p.G817G|BAIAP3_ENST00000426824.3_Silent_p.G800G|BAIAP3_ENST00000564213.1_3'UTR	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	835					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				GGCCCGAGGGGGTGCTCCCCC	0.677000													4	18					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59962312	59962312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59962312G>A	ENST00000444766.3	-	16	2138	c.2063C>T	c.(2062-2064)cCt>cTt	p.P688L	INTS2_ENST00000251334.6_Missense_Mutation_p.P680L	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	688					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						GAATTTGATAGGAATCTGATC	0.333000													3	24					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76744460	76744460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76744460G>A	ENST00000369963.3	-	2	301	c.112C>T	c.(112-114)Cgc>Tgc	p.R38C	IMPG1_ENST00000369950.3_Missense_Mutation_p.R116C			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	116					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TCAGGGATGCGATCCAGAAAG	0.502000													12	59					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19451950	19451950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19451950C>T	ENST00000396229.2	+	3	1339	c.590C>T	c.(589-591)cCa>cTa	p.P197L	TMC5_ENST00000542583.2_Missense_Mutation_p.P197L|TMC5_ENST00000541464.1_Missense_Mutation_p.P197L|TMC5_ENST00000381414.4_Missense_Mutation_p.P197L	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	197						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AGAATCAATCCATACGCAGAC	0.488000													19	112					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187524930	187524930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187524930G>A	ENST00000441802.2	-	19	10959	c.10750C>T	c.(10750-10752)Cct>Tct	p.P3584S		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3584	Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCCATCTGAGGGTCGAGACTG	0.483000										HNSCC(5;0.00058)			8	26					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119699940	119699940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:119699940C>T	ENST00000327097.4	+	1	199	c.64C>T	c.(64-66)Cac>Tac	p.H22Y	MARCO_ENST00000541757.1_5'UTR	NM_006770.3	NP_006761.1	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	22					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGCTGCTTTTCACCAAATTGC	0.423000													22	91					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52476875	52476875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52476875G>A	ENST00000231721.2	-	2	163	c.164C>T	c.(163-165)tCc>tTc	p.S55F		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	55	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity	p.S55C(1)		kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GAGGTTCAGGGAGCCCTGGGG	0.622000													5	9					0	0	1	0	0
KCNK13	56659	broad.mit.edu	37	14	90651116	90651116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90651116G>A	ENST00000282146.4	+	2	1437	c.996G>A	c.(994-996)gtG>gtA	p.V332V		NM_022054.2	NP_071337.2	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	332						integral to membrane	potassium channel activity|voltage-gated ion channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(12)|prostate(1)|skin(4)	25		all_cancers(154;0.186)				CAGACGGGGTGGCAGAGAGTG	0.617000													36	70					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20725319	20725319	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:20725319G>A	ENST00000404938.2	+	16	2522	c.1869_splice	c.e16-1	p.D624_splice	ABCB5_ENST00000258738.6_Splice_Site_p.D179_splice	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	179	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TTCCTGTAAGGATATTAAAAA	0.343000													15	43					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55907804	55907804	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55907804C>T	ENST00000521992.1	-	3	451	c.306G>A	c.(304-306)acG>acA	p.T102T	CES5A_ENST00000319165.9_Silent_p.T73T|CES5A_ENST00000290567.9_Silent_p.T73T|CES5A_ENST00000541580.1_Intron|CES5A_ENST00000520435.1_Silent_p.T73T|CES5A_ENST00000518005.1_5'UTR	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	73						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GCTGCGGGTTCGTAAATCGCA	0.592000													8	14					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164905885	164905885	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164905885C>T	ENST00000475390.1	-	2	3177	c.2734G>A	c.(2734-2736)Gaa>Aaa	p.E912K	SLITRK3_ENST00000241274.3_Missense_Mutation_p.E912K			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	912						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						ACGTGCAGTTCCTTTAATTTG	0.532000										HNSCC(40;0.11)			30	80					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907971	12907971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12907971C>T	ENST00000317869.6	-	2	397	c.172G>A	c.(172-174)Gat>Aat	p.D58N		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1									p.D58N(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TTCTCCTTATCATATTGAACG	0.468000													32	278					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113085140	113085140	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113085140G>A	ENST00000316851.7	+	7	936	c.936G>A	c.(934-936)gaG>gaA	p.E312E	NCAM1_ENST00000401611.2_Silent_p.E321E|NCAM1_ENST00000533760.1_Silent_p.E204E|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	322	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TGGAATTAGAGGAGCAGGTCA	0.448000													9	23					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30269430	30269430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:30269430C>T	ENST00000378981.3	+	4	1141	c.820C>T	c.(820-822)Ccg>Tcg	p.P274S	MAGEB1_ENST00000397550.1_Missense_Mutation_p.P274S|MAGEB1_ENST00000397548.2_Missense_Mutation_p.P274S	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	274	MAGE.									NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						CCTATGGGGTCCGAGAGCCTA	0.507000													46	29					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212800	62212800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:62212800G>A	ENST00000519846.1	+	3	886	c.414G>A	c.(412-414)agG>agA	p.R138R	CLVS1_ENST00000518592.1_Intron|CLVS1_ENST00000325897.4_Silent_p.R138R|RP11-787D18.1_ENST00000518064.1_RNA			Q8IUQ0	CLVS1_HUMAN	clavesin 1	138	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						ATTACGGCAGGAAGATTCTTT	0.448000													4	49					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13845085	13845085	+	Missense_Mutation	SNP	C	C	T	rs146830682		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13845085C>T	ENST00000265104.4	-	32	5236	c.5132G>A	c.(5131-5133)cGa>cAa	p.R1711Q		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1711	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.R1711Q(1)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AAAGCACAGTCGTTTTTTCTC	0.453000									Kartagener syndrome				9	52					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140011714	140011714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140011714G>A	ENST00000302014.6	-	2	1484	c.855C>T	c.(853-855)ttC>ttT	p.F285F	CD14_ENST00000401743.2_Silent_p.F285F	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	285					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGCCCAGCGAACGACAGAT	0.612000													13	71					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209644	140209644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140209644G>A	ENST00000529310.1	+	1	2082	c.1968G>A	c.(1966-1968)gaG>gaA	p.E656E	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACGGTGAGCCGGCGCTGA	0.697000													18	84					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229738200	229738200	+	Silent	SNP	G	G	A	rs143676179		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:229738200G>A	ENST00000366675.3	-	4	802	c.714C>T	c.(712-714)gcC>gcT	p.A238A	TAF5L_ENST00000366676.1_Silent_p.A238A|TAF5L_ENST00000258281.2_Silent_p.A238A	NM_001025247.1	NP_001020418.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	238					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				AGACCTCTAGGGCAGCCTCGT	0.552000													11	109					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788463	42788463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42788463G>A	ENST00000372980.3	-	2	1836	c.964C>T	c.(964-966)Ctg>Ttg	p.L322L		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	322					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CCGTGGCGCAGGTTGTCCAGC	0.662000													17	36					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139390781	139390781	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139390781G>A	ENST00000277541.6	-	34	7485	c.7410C>T	c.(7408-7410)tcC>tcT	p.S2470S		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	2470					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.S2472fs*6(1)|p.S2472fs*8(1)|p.S2471fs*1(1)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGACCAGCGAGGATGGCAGCG	0.697000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			5	8					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131792974	131792974	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131792974G>A	ENST00000286355.5	-	18	5510	c.3418C>T	c.(3418-3420)Ctg>Ttg	p.L1140L	ADCY8_ENST00000377928.3_Silent_p.L1009L	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1140					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGGTCCTTCAGGATGAGATAG	0.498000										HNSCC(32;0.087)			56	99					0	0	1	0	0
SECTM1	6398	broad.mit.edu	37	17	80282490	80282490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80282490C>T	ENST00000269389.3	-	3	721	c.371G>A	c.(370-372)aGa>aAa	p.R124K	SECTM1_ENST00000580437.1_Missense_Mutation_p.R124K	NM_003004.2	NP_002995.1	Q8WVN6	SCTM1_HUMAN	secreted and transmembrane 1	124					immune response|mesoderm development|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular space|Golgi apparatus|integral to membrane|plasma membrane	cytokine activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(1)	4	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			TCTGTTATTTCTCTGGTGTCC	0.642000													20	54					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56952689	56952689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56952689C>T	ENST00000504904.3	-	7	2394	c.1675G>A	c.(1675-1677)Gaa>Aaa	p.E559K	ZNF667_ENST00000342634.3_Missense_Mutation_p.E687K|ZNF667_ENST00000292069.6_Missense_Mutation_p.E559K|ZNF667_ENST00000591790.1_3'UTR			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTCCCACATTCATTACATTCA	0.408000													23	115					0	0	1	0	0
KCNK18	338567	broad.mit.edu	37	10	118957063	118957063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118957063C>T	ENST00000334549.1	+	1	64	c.64C>T	c.(64-66)Cct>Tct	p.P22S		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	22						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		AAAGCTCTTCCCTGGCCTCTG	0.632000													24	48					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22134094	22134094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22134094C>T	ENST00000408935.1	+	1	798	c.798C>T	c.(796-798)tcC>tcT	p.S266S		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CCAGCTTCTCCATTGACAAGG	0.507000													15	54					0	0	1	0	0
JKAMP	51528	broad.mit.edu	37	14	59970692	59970692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:59970692C>T	ENST00000554271.1	+	7	1406	c.880C>T	c.(880-882)Ctt>Ttt	p.L294F	JKAMP_ENST00000356057.5_Missense_Mutation_p.L288F|RP11-701B16.2_ENST00000554253.1_RNA|JKAMP_ENST00000261247.9_Missense_Mutation_p.L280F|JKAMP_ENST00000425728.2_Missense_Mutation_p.L274F			Q9P055	JKAMP_HUMAN	JNK1/MAPK8-associated membrane protein	295					ER-associated protein catabolic process|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ubiquitin protein ligase binding			breast(1)|endometrium(1)|kidney(1)|lung(3)	6						AGATTTGCCCCTTTTGGCTTT	0.418000													36	78					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369068	22369068	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22369068C>T	ENST00000332663.2	+	1	591	c.493C>T	c.(493-495)Cga>Tga	p.R165*	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTCATTGTTCGACTTCCTTT	0.498000													42	205					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128480613	128480613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128480613G>A	ENST00000325888.8	+	10	1822	c.1561G>A	c.(1561-1563)Gag>Aag	p.E521K	FLNC_ENST00000346177.6_Missense_Mutation_p.E521K	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	521					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GGGCACAGAGGAGCCAGTGAA	0.602000													28	58					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70974966	70974966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70974966C>T	ENST00000334414.6	-	10	2472	c.2428G>A	c.(2428-2430)Gaa>Aaa	p.E810K	PTPRB_ENST00000550857.1_Missense_Mutation_p.E502K|PTPRB_ENST00000451516.2_Missense_Mutation_p.E502K|PTPRB_ENST00000551525.1_Missense_Mutation_p.E809K|PTPRB_ENST00000550358.1_Missense_Mutation_p.E810K|PTPRB_ENST00000538708.1_Missense_Mutation_p.E592K|PTPRB_ENST00000261266.5_Missense_Mutation_p.E592K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	592	Fibronectin type-III 9.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACCACATTTTCATGGATCAGT	0.463000													42	137					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53560056	53560056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:53560056G>A	ENST00000357758.3	-	3	1302	c.1119C>T	c.(1117-1119)acC>acT	p.T373T	DDHD1_ENST00000395606.1_Silent_p.T380T|DDHD1_ENST00000323669.5_Silent_p.T373T	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	373					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					CCAGTTTTTGGGTAACTGTTC	0.323000													8	49					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6128845	6128845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6128845G>A	ENST00000261405.5	-	28	3993	c.3739C>T	c.(3739-3741)Ccc>Tcc	p.P1247S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1247					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GCATCTGTGGGAGGCACCACC	0.567000													13	24					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4333791	4333791	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4333791C>T	ENST00000600324.1	-	3	264	c.197G>A	c.(196-198)gGa>gAa	p.G66E	STAP2_ENST00000594605.1_Missense_Mutation_p.G66E	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	66	PH.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAAATGCTCCCAAGTTGAG	0.567000													23	51					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29002037	29002037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29002037C>T	ENST00000282397.4	-	9	1379	c.1128G>A	c.(1126-1128)gcG>gcA	p.A376A	FLT1_ENST00000539099.1_Silent_p.A376A|FLT1_ENST00000541932.1_Silent_p.A376A	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	376	Ig-like C2-type 4.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ATTTCTCAGTCGCAGGTAACC	0.398000													27	100					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64873549	64873549	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64873549G>A	ENST00000533854.1	+	2	336	c.99G>A	c.(97-99)tgG>tgA	p.W33*	CACNG5_ENST00000169565.3_Nonsense_Mutation_p.W33*|CACNG5_ENST00000307139.3_Nonsense_Mutation_p.W33*			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	33					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CCGACTACTGGCTGTACCTGG	0.607000													17	72					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204588393	204588393	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204588393G>A	ENST00000367175.1	-	1	2940	c.728C>T	c.(727-729)tCc>tTc	p.S243F	LRRN2_ENST00000367176.3_Missense_Mutation_p.S243F|LRRN2_ENST00000367177.3_Missense_Mutation_p.S243F			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	243					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GTCATAGAAGGAGAGGCTCTC	0.642000													15	59					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248636944	248636944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248636944C>T	ENST00000359594.2	+	1	318	c.293C>T	c.(292-294)tCc>tTc	p.S98F		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATACCATTTCCCCGTCAGGC	0.542000													15	41					0	0	1	0	0
MOSPD3	64598	broad.mit.edu	37	7	100210593	100210593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100210593C>T	ENST00000393950.2	+	1	461	c.179C>T	c.(178-180)cCc>cTc	p.P60L	MOSPD3_ENST00000223054.4_Missense_Mutation_p.P60L|MOSPD3_ENST00000379527.2_Missense_Mutation_p.P60L|MOSPD3_ENST00000424091.2_Missense_Mutation_p.P60L	NM_023948.4	NP_076438.1	O75425	MSPD3_HUMAN	motile sperm domain containing 3	60	MSP.					integral to membrane	structural molecule activity			breast(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CTCTATAACCCCACAGGAACT	0.647000													28	139					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45484823	45484823	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45484823G>A	ENST00000334940.6	+	7	794	c.660_splice	c.e7+1	p.R220_splice	RASSF4_ENST00000472561.1_3'UTR|RASSF4_ENST00000340258.4_Splice_Site_p.R211_splice|RASSF4_ENST00000374417.2_3'UTR			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	211	Ras-associating.				cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						ACAAATTTAGGGTAAGCCTGG	0.577000													10	21					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110830538	110830538	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110830538G>A	ENST00000375820.4	-	32	2620	c.2499C>T	c.(2497-2499)ttC>ttT	p.F833F		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	833	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCAGTCCAGGGAATCCGGGGA	0.522000													28	93					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37398589	37398589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37398589G>A	ENST00000535679.1	-	6	768	c.769C>T	c.(769-771)Ctt>Ttt	p.L257F	SULT6B1_ENST00000379149.2_Missense_Mutation_p.L153F|SULT6B1_ENST00000260637.3_Missense_Mutation_p.L219F|SULT6B1_ENST00000407963.1_Missense_Mutation_p.L219F			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	257						cytoplasm	sulfotransferase activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				TTGCGGAAAAGGAATGGGCCG	0.463000													41	115					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152882619	152882619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152882619G>A	ENST00000368764.3	+	2	410	c.346G>A	c.(346-348)Gat>Aat	p.D116N	IVL_ENST00000392667.2_5'UTR			P07476	INVO_HUMAN	involucrin	116					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AACACAAAGGGATCAGCAGCT	0.473000													21	44					0	0	1	0	0
TMCC3	57458	broad.mit.edu	37	12	94965318	94965318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:94965318G>A	ENST00000261226.4	-	4	1458	c.1327C>T	c.(1327-1329)Cgc>Tgc	p.R443C	TMCC3_ENST00000551457.1_Missense_Mutation_p.R412C	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	443						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						ATGTGGCAGCGACTCTTCATC	0.478000													53	91					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99456460	99456460	+	Missense_Mutation	SNP	C	C	T	rs45483397		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:99456460C>T	ENST00000268035.6	+	8	2388	c.1777C>T	c.(1777-1779)Cat>Tat	p.H593Y	IGF1R_ENST00000558762.1_Missense_Mutation_p.H593Y	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	593	Fibronectin type-III 1.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GGAGAACGACCATATCCGTGG	0.552000													27	137					0	0	1	0	0
SF3A3	10946	broad.mit.edu	37	1	38435103	38435103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38435103G>A	ENST00000373019.4	-	14	2159	c.1204C>T	c.(1204-1206)Cta>Tta	p.L402L	SF3A3_ENST00000448721.2_Silent_p.L349L	NM_006802.2	NP_006793.1	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3, 60kDa	402					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|prostate(2)	12	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TTGATATTTAGGCCATGAAGC	0.398000													11	96					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31404690	31404690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31404690C>T	ENST00000389202.2	+	1	58	c.9C>T	c.(7-9)ttC>ttT	p.F3F		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	3					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGATGACCTTCGGCACTGTGC	0.587000													34	87					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881789	228881789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228881789C>T	ENST00000392056.3	-	7	3827	c.3781G>A	c.(3781-3783)Gat>Aat	p.D1261N	SPHKAP_ENST00000344657.5_Missense_Mutation_p.D1261N	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1261						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCAAAGCCATCTAAAGAGTTG	0.542000													18	64					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439343	150439343	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150439343G>A	ENST00000358647.3	+	3	483	c.116G>A	c.(115-117)gGg>gAg	p.G39E	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACAGGCTGCGGGAAAAGTGCC	0.507000													31	73					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20976437	20976437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:20976437C>T	ENST00000380249.1	+	38	4515	c.4151C>T	c.(4150-4152)cCt>cTt	p.P1384L	FOCAD_ENST00000338382.6_Missense_Mutation_p.P1384L|FOCAD_ENST00000605086.1_Missense_Mutation_p.P820L	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	1384						integral to membrane	binding										TCTGTGCCTCCTTCCCTTCTT	0.418000													25	245					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52880906	52880906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52880906G>A	ENST00000356971.3	-	9	1295	c.806C>T	c.(805-807)cCc>cTc	p.P269L	ICK_ENST00000350082.5_Missense_Mutation_p.P269L	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	269	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TCGTTTCTTGGGATCCCACTG	0.408000													38	79					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120530855	120530855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120530855G>A	ENST00000397558.2	+	9	1612	c.1612G>A	c.(1612-1614)Gaa>Aaa	p.E538K	CCDC64_ENST00000257583.4_Missense_Mutation_p.E235K|CCDC64_ENST00000546857.1_3'UTR|CCDC64_ENST00000446727.2_Missense_Mutation_p.E209K	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	538					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCACCTGAAAGAACGGAGCCA	0.622000													18	66					0	0	1	0	0
EIF2D	1939	broad.mit.edu	37	1	206769163	206769163	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206769163G>A	ENST00000271764.2	-	13	1621	c.1413C>T	c.(1411-1413)gcC>gcT	p.A471A	EIF2D_ENST00000472709.2_5'UTR|EIF2D_ENST00000367114.3_Silent_p.A347A	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	471					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						TCACTTGATAGGCAGGCTGTA	0.438000													42	164					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160977153	160977153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160977153C>T	ENST00000447678.1	-	31	4997	c.4877G>A	c.(4876-4878)gGc>gAc	p.G1626D	LPA_ENST00000316300.5_Missense_Mutation_p.G1626D	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4134	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGAGAATGTGCCTCGATAACT	0.483000													27	149					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205273195	205273195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205273195C>T	ENST00000367157.3	-	7	1396	c.1270G>A	c.(1270-1272)Gag>Aag	p.E424K		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	424					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGAGGGTCCTCCTGTACCCCT	0.627000													27	82					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102851377	102851377	+	Missense_Mutation	SNP	G	G	A	rs34289672		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102851377G>A	ENST00000264257.2	+	11	1444	c.1318G>A	c.(1318-1320)Gaa>Aaa	p.E440K	IL1RL2_ENST00000539491.1_Missense_Mutation_p.E440K|IL1RL2_ENST00000441515.2_Missense_Mutation_p.E322K|IL1RL2_ENST00000481806.1_3'UTR	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	440	TIR.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						TGTCATCGATGAAAACGTTAA	0.463000													29	68					0	0	1	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841655	8841655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8841655G>A	ENST00000324060.2	+	1	340	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCTGCGGGGAGAAGGTGCCAC	0.547000													26	63					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177553	89177553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:89177553C>T	ENST00000561129.2	+	1	599	c.469C>T	c.(469-471)Ctg>Ttg	p.L157L	TGIF2LX_ENST00000283891.5_Silent_p.L157L			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	157						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						TGTACAAAGCCTGCCCCTGTG	0.612000													9	29					0	0	1	0	0
MBD3	53615	broad.mit.edu	37	19	1581114	1581114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1581114G>A	ENST00000590550.2	-	4	859	c.486C>T	c.(484-486)ttC>ttT	p.F162F	MBD3_ENST00000156825.1_Silent_p.F218F|MBD3_ENST00000592012.1_Silent_p.F186F|MBD3_ENST00000434436.3_Silent_p.F218F			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	218					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGTCACCATGAAGGCTTTGC	0.647000													11	42					0	0	1	0	0
IGJ	3512	broad.mit.edu	37	4	71527857	71527857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71527857G>A	ENST00000254801.4	-	2	309	c.140C>T	c.(139-141)tCt>tTt	p.S47F	IGJ_ENST00000543780.1_Missense_Mutation_p.S63F|ENAM_ENST00000472903.1_3'UTR	NM_144646.3	NP_653247.1	P01591	IGJ_HUMAN	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	47					immune response	extracellular region	antigen binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7			Lung(101;0.235)			ATCTTCGGAAGAACGGATGAT	0.388000													20	104					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179590257	179590257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179590257C>T	ENST00000589042.1	-	71	20898	c.20674G>A	c.(20674-20676)Gaa>Aaa	p.E6892K	TTN_ENST00000342992.6_Missense_Mutation_p.E5648K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E6575K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6575	Ig-like 50.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCACTTCTTCCTTCTCTTTA	0.433000													18	62					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701557	143701557	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143701557C>T	ENST00000408922.2	+	1	536	c.468C>T	c.(466-468)tcC>tcT	p.S156S		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TTGGCATCTCCCTGGCGAAGA	0.532000													27	46					0	0	1	0	0
PROL1	58503	broad.mit.edu	37	4	71265027	71265027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71265027C>T	ENST00000399575.2	+	2	199	c.25C>T	c.(25-27)Ctg>Ttg	p.L9L	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	9					regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				CTTCTTGGGCCTGTTGGCTCT	0.318000													4	46					0	0	1	0	0
SBK2	646643	broad.mit.edu	37	19	56041213	56041213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56041213G>A	ENST00000413299.1	-	4	971	c.934C>T	c.(934-936)Ccc>Tcc	p.P312S	SBK2_ENST00000344158.3_Missense_Mutation_p.P312S	NM_001101401.2	NP_001094871.2	P0C263	SBK2_HUMAN	SH3 domain binding kinase family, member 2	312	Protein kinase.						ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						CTCCTTCGGGGGTGAGGGTCC	0.751000													14	23					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219538350	219538350	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219538350C>T	ENST00000295709.3	+	3	366	c.87C>T	c.(85-87)gtC>gtT	p.V29V	STK36_ENST00000392106.2_Silent_p.V29V|STK36_ENST00000392105.3_Silent_p.V29V|STK36_ENST00000440309.1_Silent_p.V29V	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	29	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		ACTGACAGGTCGTGGCCCTGA	0.458000													9	45					0	0	1	0	0
DHRS7C	201140	broad.mit.edu	37	17	9676110	9676110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:9676110C>T	ENST00000330255.4	-	5	716	c.704G>A	c.(703-705)gGa>gAa	p.G235E	DHRS7C_ENST00000571134.1_Missense_Mutation_p.G234E	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	235						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						TTCCCAGTTTCCTTGCTCTGG	0.562000													17	23					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76755238	76755238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76755238G>A	ENST00000536229.3	+	2	3341	c.2632G>A	c.(2632-2634)Ggc>Agc	p.G878S	SALL3_ENST00000537592.2_Missense_Mutation_p.G1083S|SALL3_ENST00000575389.2_Missense_Mutation_p.G1011S			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1083					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCTGCCCGCGGGCGTCCAGGT	0.711000													11	12					0	0	1	0	0
POLR1A	25885	broad.mit.edu	37	2	86327250	86327250	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:86327250G>A	ENST00000263857.6	-	2	501	c.123C>T	c.(121-123)agC>agT	p.S41S	POLR1A_ENST00000409681.1_Silent_p.S41S			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	41					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						GGTTCCCCAGGCTGTCCAGGT	0.483000													25	63					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93104332	93104332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93104332C>T	ENST00000298050.3	+	7	775	c.675C>T	c.(673-675)ttC>ttT	p.F225F		NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	225										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				GAGATGAGTTCATTATTGAAA	0.348000													10	19					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8188758	8188758	+	Missense_Mutation	SNP	C	C	T	rs138166112		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8188758C>T	ENST00000600128.1	-	23	3280	c.2866G>A	c.(2866-2868)Gat>Aat	p.D956N	FBN3_ENST00000601739.1_Missense_Mutation_p.D956N|FBN3_ENST00000270509.2_Missense_Mutation_p.D956N			Q75N90	FBN3_HUMAN	fibrillin 3	956	TB 5.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GACTCGGGATCCGGGCAGGCC	0.662000													9	37					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43507295	43507295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43507295C>T	ENST00000300215.3	-	3	975	c.518G>A	c.(517-519)aGa>aAa	p.R173K	EPB42_ENST00000540029.1_Intron|EPB42_ENST00000441366.2_Missense_Mutation_p.R143K			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	143					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		AAACTTACCTCTATTCCAGGG	0.597000													9	32					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	939091	939091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:939091C>T	ENST00000265846.5	-	9	1051	c.832G>A	c.(832-834)Gat>Aat	p.D278N	ADAP1_ENST00000449296.2_Missense_Mutation_p.D206N|ADAP1_ENST00000539900.1_Missense_Mutation_p.D289N	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	278	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						CTGCGGTCATCCATGGTGAAC	0.637000													15	23					0	0	1	0	0
LEPREL1	55214	broad.mit.edu	37	3	189689737	189689737	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189689737C>T	ENST00000319332.5	-	12	1956	c.1759G>A	c.(1759-1761)Gat>Aat	p.D587N	LEPREL1_ENST00000427335.2_Missense_Mutation_p.D406N	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	587	Fe2OG dioxygenase.				collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GCCTCTGGATCCAACAAACAG	0.453000													14	34					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719243	140719243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140719243G>A	ENST00000394576.2	+	1	705	c.705G>A	c.(703-705)gcG>gcA	p.A235A	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1												p.A235A(2)		breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCTGGATGCGAACGACAATG	0.592000													28	82					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92495284	92495284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92495284G>A	ENST00000298047.6	+	4	3949	c.3932G>A	c.(3931-3933)gGg>gAg	p.G1311E	FAT3_ENST00000409404.2_Missense_Mutation_p.G1311E|RP11-203F8.1_ENST00000529884.1_RNA|FAT3_ENST00000525166.1_Missense_Mutation_p.G1161E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1311	Cadherin 12.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTAAAACTGGGATGGTTTCT	0.453000										TCGA Ovarian(4;0.039)			13	75					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36362863	36362863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36362863G>A	ENST00000221891.4	+	6	967	c.775G>A	c.(775-777)Gag>Aag	p.E259K	APLP1_ENST00000586861.1_Missense_Mutation_p.E253K|APLP1_ENST00000537454.2_Missense_Mutation_p.E220K	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	259					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TTACTTCGTGGAGCCTCCGCA	0.622000													50	173					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314090	67314090	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67314090C>T	ENST00000360461.5	+	1	2678	c.143C>T	c.(142-144)cCt>cTt	p.P48L	PLEKHG4_ENST00000379344.3_Missense_Mutation_p.P48L|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.P48L|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.P48L	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	48					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		GACCCAGGTCCTCCAAGACCA	0.602000													8	61					0	0	1	0	0
WFDC2	10406	broad.mit.edu	37	20	44108722	44108722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44108722C>T	ENST00000342873.3	+	1	644	c.211C>T	c.(211-213)Ccc>Tcc	p.P71S	WFDC2_ENST00000339946.3_Missense_Mutation_p.P74S|WFDC2_ENST00000372676.3_Missense_Mutation_p.P122S|WFDC2_ENST00000488143.1_3'UTR			Q14508	WFDC2_HUMAN	WAP four-disulfide core domain 2	122	WAP 1.			SL -> LLC (in Ref. 1; CAA44869 and 2; AAL37485).	proteolysis|spermatogenesis	extracellular space	serine-type endopeptidase inhibitor activity			lung(1)	1		Myeloproliferative disorder(115;0.0122)				CTGTGTCACTCCCAATTTCTG	0.572000													31	110					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730213	57730213	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57730213G>A	ENST00000281282.5	+	2	94	c.16G>A	c.(16-18)Ggt>Agt	p.G6S		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	6	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		GCTGTATTTCGGTGAATATCA	0.443000													141	278					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64981737	64981737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:64981737G>A	ENST00000268603.4	-	13	2775	c.2160C>T	c.(2158-2160)ttC>ttT	p.F720F	CDH11_ENST00000394156.3_3'UTR|CDH11_ENST00000566827.1_Silent_p.F594F	NM_001797.2	NP_001788.2	P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	720					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TCGTGTTGATGAAGTCATCGA	0.532000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			34	78					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325940	158325940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158325940C>T	ENST00000434258.1	+	4	954	c.943C>T	c.(943-945)Ctg>Ttg	p.L315L	CD1E_ENST00000368161.3_Intron|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368167.3_Intron|CD1E_ENST00000368163.3_Intron|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368160.3_Intron|CD1E_ENST00000444681.2_Intron|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368165.3_Intron			P15812	CD1E_HUMAN	CD1e molecule	0					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GAAAATAGCCCTGGGGCTTTT	0.473000													8	26					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167675260	167675260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167675260C>T	ENST00000519204.1	+	26	7071	c.6953C>T	c.(6952-6954)tCc>tTc	p.S2318F	TENM2_ENST00000403607.2_Missense_Mutation_p.S2263F|TENM2_ENST00000545108.1_Missense_Mutation_p.S2438F|TENM2_ENST00000518659.1_Missense_Mutation_p.S2439F|TENM2_ENST00000520394.1_Missense_Mutation_p.S2200F					teneurin transmembrane protein 2																		CGATGGACCTCCCCAGACTAT	0.522000													14	40					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31432838	31432838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31432838C>T	ENST00000261592.5	-	11	2182	c.1885G>A	c.(1885-1887)Gaa>Aaa	p.E629K	NOL4_ENST00000269185.4_Missense_Mutation_p.E413K|NOL4_ENST00000535384.1_Missense_Mutation_p.E344K|NOL4_ENST00000535475.1_Missense_Mutation_p.E410K|NOL4_ENST00000589544.1_Missense_Mutation_p.E527K|NOL4_ENST00000538587.1_Missense_Mutation_p.E555K	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	629						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TTTTCCAGTTCATCTGCAGAT	0.418000													6	65					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223272	44223272	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44223272G>A	ENST00000244314.5	+	2	761	c.562G>A	c.(562-564)Gcc>Acc	p.A188T		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	188						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CTTCAGAGAGGCCGCTGTCCT	0.672000													16	42					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32181595	32181595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32181595C>T	ENST00000375023.3	-	14	2328	c.2190G>A	c.(2188-2190)atG>atA	p.M730I	NOTCH4_ENST00000465528.1_5'UTR	NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	730	EGF-like 19.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GACAAGCTGTCATCTCCTCAC	0.597000													15	38					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75886311	75886311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75886311C>T	ENST00000274364.6	+	8	1016	c.719C>T	c.(718-720)cCa>cTa	p.P240L	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	240					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CTAAGAAACCCAAATGCGGTT	0.378000													38	57					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234550	21234550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21234550C>T	ENST00000233242.1	-	26	5317	c.5190G>A	c.(5188-5190)aaG>aaA	p.K1730K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1730					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTGACTGACCTTGAAGTTGA	0.448000													79	274					0	0	1	0	0
CCDC74A	90557	broad.mit.edu	37	2	132290506	132290506	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132290506C>T	ENST00000295171.6	+	6	1084	c.946C>T	c.(946-948)Ccc>Tcc	p.P316S	CCDC74A_ENST00000467992.2_3'UTR|CCDC74A_ENST00000409856.3_Missense_Mutation_p.P250S	NM_001258304.1|NM_001258305.1|NM_138770.2	NP_001245233.1|NP_001245234.1|NP_620125.1	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	316										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						AGCTAGCTTTCCCAGGTGAGT	0.647000													26	65					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124303686	124303686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124303686G>A	ENST00000291478.4	+	1	181	c.18G>A	c.(16-18)agG>agA	p.R6R	KALRN_ENST00000428018.2_Silent_p.R6R|KALRN_ENST00000360013.3_Intron|KALRN_ENST00000393496.1_Intron	NM_007064.3	NP_008995.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	0					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCGGCGACAGGGCTTACACCC	0.677000													4	7					0	0	1	0	0
WBSCR28	135886	broad.mit.edu	37	7	73279445	73279445	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73279445C>T	ENST00000320531.2	+	2	231	c.195C>T	c.(193-195)ccC>ccT	p.P65P		NM_182504.3	NP_872310.2	Q6UE05	WBS28_HUMAN	Williams-Beuren syndrome chromosome region 28	65						integral to membrane				breast(2)|kidney(2)|lung(6)|skin(1)	11		Lung NSC(55;0.159)				CCCACCTACCCCTGGGAGCTG	0.632000													43	185					0	0	1	0	0
MFAP3L	9848	broad.mit.edu	37	4	170912824	170912824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:170912824G>A	ENST00000361618.3	-	3	1242	c.935C>T	c.(934-936)cCt>cTt	p.P312L	MFAP3L_ENST00000393704.3_Missense_Mutation_p.P209L|RP11-6E9.4_ENST00000508955.1_RNA	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	312						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		AATTTGCTGAGGTTGCTCGTG	0.552000													5	48					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1987498	1987498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:1987498G>A	ENST00000382722.5	-	16	2064	c.1702C>T	c.(1702-1704)Ccc>Tcc	p.P568S	CACNA2D4_ENST00000586184.1_Missense_Mutation_p.P568S|CACNA2D4_ENST00000585732.1_Missense_Mutation_p.P453S|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.P504S|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.P504S	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	568	Cache.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CGGAGGTCGGGATGGGAGAGG	0.507000													4	6					0	0	1	0	0
TRGV4	6977	broad.mit.edu	37	7	38393601	38393601	+	RNA	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38393601T>A	ENST00000390345.2	-	0	402																											TCGTTCTCCCTTCCAAGTTGG	0.433000													33	76					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862573	14862573	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14862573G>A	ENST00000285046.5	+	1	2105	c.1995G>A	c.(1993-1995)acG>acA	p.T665T	FGD5_ENST00000543601.1_Silent_p.T424T	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	665					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						AGAAGAAGACGGAGAACAAAT	0.512000													9	57					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12122504	12122504	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:12122504C>T	ENST00000379388.2	+	4	2808	c.2476C>T	c.(2476-2478)Ctg>Ttg	p.L826L		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	826					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGTGTTTCTTCTGTCTGTACC	0.418000													64	133					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5011861	5011861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5011861C>T	ENST00000380390.1	+	4	570	c.354C>T	c.(352-354)tcC>tcT	p.S118S	MMP26_ENST00000300762.1_Silent_p.S118S			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	118					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGAAGCCATCCGCAGTGAAAG	0.393000													34	66					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48269226	48269226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48269226C>T	ENST00000225964.5	-	31	2168	c.2050G>A	c.(2050-2052)Gag>Aag	p.E684K		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	684	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	ACACCACGCTCGCCAGGGAAA	0.642000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						3	13					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54914569	54914569	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54914569G>A	ENST00000545554.1	+	30	6151	c.6151G>A	c.(6151-6153)Gac>Aac	p.D2051N	UNC13C_ENST00000537900.1_Missense_Mutation_p.D2049N|UNC13C_ENST00000539562.2_5'UTR|UNC13C_ENST00000260323.11_Missense_Mutation_p.D2051N			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2051	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGTTCATGTGGACATCACTGC	0.443000													32	65					0	0	1	0	0
SLC22A16	85413	broad.mit.edu	37	6	110763791	110763791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110763791G>A	ENST00000368919.3	-	4	905	c.839C>T	c.(838-840)cCc>cTc	p.P280L	SLC22A16_ENST00000456137.2_3'UTR|SLC22A16_ENST00000439654.1_Missense_Mutation_p.P280L|SLC22A16_ENST00000330550.4_Missense_Mutation_p.P246L	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	280					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CAGGATAAAGGGGACAGTCAC	0.488000													32	46					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24209511	24209511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24209511G>A	ENST00000265769.4	+	21	2300	c.2190G>A	c.(2188-2190)atG>atA	p.M730I	RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000397649.3_Missense_Mutation_p.E479K|RP11-624C23.1_ENST00000519689.1_RNA	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	730					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TGAGTCAGATGAAGCCCCATG	0.383000													30	76					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624451	123624451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123624451C>T	ENST00000327930.2	-	1	802	c.776G>A	c.(775-777)aGa>aAa	p.R259K		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGCTGTGGGTCTTAGGTACAT	0.463000													20	68					0	0	1	0	0
CLEC4G	339390	broad.mit.edu	37	19	7796584	7796584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7796584G>A	ENST00000328853.5	-	2	197	c.129C>T	c.(127-129)gtC>gtT	p.V43V	CLEC4G_ENST00000598081.1_5'UTR	NM_001244856.1|NM_198492.3	NP_001231785.1|NP_940894.1	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	43						integral to membrane	protein binding|sugar binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(1)|lung(1)	6						CAGCCCAAAGGACTGTGGTGA	0.607000													19	34					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64622825	64622825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64622825G>A	ENST00000320631.3	-	4	1303	c.1049C>T	c.(1048-1050)cCt>cTt	p.P350L	EHD1_ENST00000359393.2_Missense_Mutation_p.P350L	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	350					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						GAAGTCCCCAGGGGAGATCTG	0.582000											OREG0004024	type=REGULATORY REGION|Gene=EHD1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	25	59					0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50813813	50813813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50813813C>T	ENST00000540145.1	+	9	1791	c.1376C>T	c.(1375-1377)cCc>cTc	p.P459L	CYLD_ENST00000564326.1_Missense_Mutation_p.P456L|CYLD_ENST00000427738.3_Missense_Mutation_p.P459L|CYLD_ENST00000398568.2_Missense_Mutation_p.P456L|CYLD_ENST00000569418.1_Missense_Mutation_p.P456L|CYLD_ENST00000568704.2_Intron|CYLD_ENST00000566206.1_Missense_Mutation_p.P456L|CYLD_ENST00000311559.9_Missense_Mutation_p.P459L			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	459	Interaction with TRAF2.|Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				GAGAGTCCACCCTTGGCCATG	0.512000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				17	87					0	0	1	0	0
SRSF5	6430	broad.mit.edu	37	14	70238135	70238135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70238135C>T	ENST00000553521.1	+	9	2229	c.776C>T	c.(775-777)tCc>tTc	p.S259F	SRSF5_ENST00000394366.2_Missense_Mutation_p.S259F|SRSF5_ENST00000553635.1_Missense_Mutation_p.S256F|SRSF5_ENST00000556587.1_3'UTR|SRSF5_ENST00000557154.1_Missense_Mutation_p.S259F			Q13243	SRSF5_HUMAN	serine/arginine-rich splicing factor 5	259	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding			large_intestine(1)|liver(1)	2						CGCCAGAGGTCCCGGTCCCGA	0.463000													60	151					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53007517	53007517	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53007517G>A	ENST00000305748.3	-	5	973	c.939C>T	c.(937-939)atC>atT	p.I313I	RP11-641A6.2_ENST00000552364.1_RNA|RP11-641A6.2_ENST00000549180.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	313	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTTCCGGGCGATCTCCTCAT	0.597000													33	82					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41795943	41795943	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:41795943G>A	ENST00000301831.4	-	22	2693	c.2231C>T	c.(2230-2232)cCc>cTc	p.P744L		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	744							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GCATGTTGAGGGGCTGTCAAG	0.368000													16	83					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95111341	95111341	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95111341G>A	ENST00000469935.1	+	0	1161					NR_015340.1																						AGAACCTGCAGACTGGAGATG	0.502000													15	54					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21263862	21263862	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21263862C>T	ENST00000233242.1	-	4	458	c.331G>A	c.(331-333)Gcc>Acc	p.A111T	APOB_ENST00000399256.4_Missense_Mutation_p.A111T	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	111	Heparin-binding.|Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCAGCAAGGCTTTGCCCTCA	0.527000													11	48					0	0	1	0	0
TNIP3	79931	broad.mit.edu	37	4	122075732	122075732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122075732C>T	ENST00000454328.1	-	7	693	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	TNIP3_ENST00000507879.1_Missense_Mutation_p.E226K|TNIP3_ENST00000057513.3_Missense_Mutation_p.E156K|TNIP3_ENST00000509841.1_Missense_Mutation_p.E233K			Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	156										NS(1)|endometrium(4)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(2)	24						ATTTCACATTCGTAATGTTCC	0.358000													29	73					0	0	1	0	0
TRA2B	6434	broad.mit.edu	37	3	185638963	185638963	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185638963G>A	ENST00000453386.2	-	6	926	c.651C>T	c.(649-651)cgC>cgT	p.R217R	TRA2B_ENST00000382191.4_Silent_p.R117R	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	217	Linker.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						AATCCCGACGGCGAGAGCTGC	0.418000													25	72					0	0	1	0	0
PAGE4	9506	broad.mit.edu	37	X	49597176	49597176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:49597176G>A	ENST00000218068.6	+	4	294	c.215G>A	c.(214-216)cGg>cAg	p.R72Q	PAGE4_ENST00000376141.1_Missense_Mutation_p.R72Q	NM_007003.2	NP_008934.1	O60829	GAGC1_HUMAN	P antigen family, member 4 (prostate associated)	72												Ovarian(276;0.236)					GAAAAGACTCGGAGTGAGCGT	0.358000													7	30					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045909	87045909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87045909C>T	ENST00000370563.3	+	14	2683	c.2641C>T	c.(2641-2643)Cct>Tct	p.P881S	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	881						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		tacacctactcctactcctac	0.348000													14	48					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72299495	72299495	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72299495G>A	ENST00000263563.6	+	15	2153	c.1885G>A	c.(1885-1887)Gac>Aac	p.D629N		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CCCCATGCCGGACTTCTGTGC	0.662000													23	66					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115782979	115782979	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:115782979G>T	ENST00000343348.6	-	19	3210	c.2423C>A	c.(2422-2424)tCc>tAc	p.S808Y	SEMA6A_ENST00000510263.1_Missense_Mutation_p.S808Y|SEMA6A_ENST00000257414.8_Missense_Mutation_p.S825Y|SEMA6A_ENST00000503865.1_Missense_Mutation_p.S187Y|SEMA6A_ENST00000282394.6_Missense_Mutation_p.S285Y|SEMA6A_ENST00000513137.1_Missense_Mutation_p.S235Y	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	808	Pro-rich.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GTGGCTGGGGGAGGCCCGCAG	0.642000													26	64					9.04412e-07	9.0662e-07	1	1	0
CDK5RAP1	51654	broad.mit.edu	37	20	31967359	31967359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31967359G>A	ENST00000357886.4	-	9	1210	c.1057C>T	c.(1057-1059)Cgt>Tgt	p.R353C	CDK5RAP1_ENST00000473997.1_5'UTR|CDK5RAP1_ENST00000339269.5_Intron|CDK5RAP1_ENST00000544843.1_Missense_Mutation_p.R339C|CDK5RAP1_ENST00000452723.3_Missense_Mutation_p.R249C|CDK5RAP1_ENST00000346416.2_Missense_Mutation_p.R339C			Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	353					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity	p.R339C(1)		endometrium(2)|kidney(2)|large_intestine(3)|lung(12)|ovary(3)|skin(3)|urinary_tract(1)	26						TGAGCAAAACGAAGTCCTCCT	0.483000													23	39					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122854132	122854132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122854132G>A	ENST00000264811.5	-	1	480	c.62C>T	c.(61-63)gCt>gTt	p.A21V	TRPC3_ENST00000513531.1_Missense_Mutation_p.A21V|TRPC3_ENST00000379645.3_Missense_Mutation_p.A94V	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	9					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCCCCTGACAGCCTGGCGCCG	0.607000													7	50					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49736512	49736512	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49736512C>T	ENST00000327697.6	+	10	882	c.738C>T	c.(736-738)gcC>gcT	p.A246A	RNF123_ENST00000432042.1_Silent_p.A100A	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	246	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		AGTCCGTGGCCTTCAACTTTG	0.582000													29	97					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34863731	34863731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34863731G>A	ENST00000431794.3	-	15	1786	c.1264C>T	c.(1264-1266)Cct>Tct	p.P422S	MYO19_ENST00000268852.9_Missense_Mutation_p.P422S	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	422	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGTTGTCAGGAAATGATTCA	0.537000													7	28					0	0	1	0	0
SYNGR1	9145	broad.mit.edu	37	22	39773623	39773623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39773623C>T	ENST00000318801.4	+	4	590	c.504C>T	c.(502-504)gcC>gcT	p.A168A	SYNGR1_ENST00000328933.5_Intron|SYNGR1_ENST00000381535.4_Silent_p.A169A	NM_145731.3	NP_663783.1			synaptogyrin 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	7	Melanoma(58;0.04)					CAGCCCTGGCCGTGCGGAGAT	0.672000													7	27					0	0	1	0	0
MANBA	4126	broad.mit.edu	37	4	103592516	103592516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:103592516C>T	ENST00000226578.4	-	9	1251	c.1152G>A	c.(1150-1152)atG>atA	p.M384I	MANBA_ENST00000505239.1_Missense_Mutation_p.M327I	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	384					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		GAAGAGTATTCATATTAGCAT	0.353000													18	35					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540249	169540249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169540249C>T	ENST00000340806.6	+	1	540	c.540C>T	c.(538-540)ttC>ttT	p.F180F		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	180										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						TTGAAGTTTTCCCCCAGGAGC	0.517000													34	86					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9021059	9021059	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9021059C>T	ENST00000397910.4	-	19	37467	c.37264G>A	c.(37264-37266)Ggt>Agt	p.G12422S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12424	SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCACCAGACCCTGCAGGACC	0.547000													29	129					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119583407	119583407	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119583407G>A	ENST00000267260.4	+	9	1381	c.993G>A	c.(991-993)ggG>ggA	p.G331G		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	331	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding	p.G331fs*37(2)		breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						CTGATTCAGGGAACTCCTTCA	0.612000													4	20					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48370691	48370691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48370691G>A	ENST00000395702.2	+	2	386	c.159G>A	c.(157-159)acG>acA	p.T53T	ZNF488_ENST00000586537.1_5'UTR|ZNF488_ENST00000494156.1_Silent_p.T53T			Q96MN9	ZN488_HUMAN	zinc finger protein 488	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						TCGAGAAGACGAACCGCCTGG	0.677000													25	59					0	0	1	0	0
LY6K	54742	broad.mit.edu	37	8	143783057	143783057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143783057G>A	ENST00000522591.1	+	2	199	c.143G>A	c.(142-144)aGa>aAa	p.R48K	LY6K_ENST00000519390.1_3'UTR|LY6K_ENST00000292430.6_Missense_Mutation_p.R48K|LY6K_ENST00000519387.1_Missense_Mutation_p.R48K|LY6K_ENST00000561179.1_Missense_Mutation_p.R106K|LY6K_ENST00000518841.1_Missense_Mutation_p.R48K			Q17RY6	LY6K_HUMAN	lymphocyte antigen 6 complex, locus K	48	UPAR/Ly6.					anchored to membrane|cytoplasm|extracellular region|nucleolus|plasma membrane				NS(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)	10	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GTTTGTGAGAGAGAAAACACT	0.473000													9	43					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226910	24226910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24226910C>T	ENST00000345044.6	+	12	1633	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	SLC2A11_ENST00000316185.8_Silent_p.F458F|SLC2A11_ENST00000398356.2_Silent_p.F462F|AP000350.10_ENST00000433835.3_Intron			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	455						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						CTGGCCTGTTCCTTCCTGAGA	0.562000													51	144					0	0	1	0	0
B3GNT7	93010	broad.mit.edu	37	2	232263400	232263400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:232263400C>T	ENST00000287590.5	+	2	1231	c.970C>T	c.(970-972)Ccg>Tcg	p.P324S		NM_145236.2	NP_660279.1	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	324					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)	17		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		GGAGCTCTACCCGATCGACGA	0.672000													9	53					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070414	114070414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:114070414G>A	ENST00000462705.1	-	11	1113	c.292C>T	c.(292-294)Ctg>Ttg	p.L98L	ZBTB20_ENST00000474710.1_Silent_p.L171L|ZBTB20_ENST00000357258.3_Silent_p.L98L|ZBTB20_ENST00000471418.1_Silent_p.L98L|ZBTB20_ENST00000481632.1_Silent_p.L98L|ZBTB20_ENST00000464560.1_Silent_p.L98L|ZBTB20_ENST00000393785.2_Silent_p.L98L	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		AGGATCTGCAGAGCTTCCGAC	0.582000													29	42					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936471	4936471	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4936471G>A	ENST00000322013.3	-	1	451	c.423C>T	c.(421-423)ctC>ctT	p.L141L	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTGTTGGTGAGAATGGAAA	0.478000													12	52					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323156	61323156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61323156C>T	ENST00000283752.5	-	8	1051	c.908G>A	c.(907-909)gGa>gAa	p.G303E	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.G251E	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	303					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						ATCCACCATTCCCATGGTTCT	0.502000													27	121					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94173221	94173221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94173221G>A	ENST00000553484.1	+	51	8099	c.7945G>A	c.(7945-7947)Gaa>Aaa	p.E2649K	UNC79_ENST00000555664.1_Missense_Mutation_p.E2588K|UNC79_ENST00000393151.2_Missense_Mutation_p.E2627K|UNC79_ENST00000256339.4_Missense_Mutation_p.E2450K			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2627						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCAGTCCTCGGAAGCAGCCTC	0.527000													20	66					0	0	1	0	0
MVP	9961	broad.mit.edu	37	16	29856066	29856066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29856066C>T	ENST00000357402.5	+	11	2025	c.1887C>T	c.(1885-1887)ccC>ccT	p.P629P	MVP_ENST00000395353.1_Silent_p.P629P	NM_005115.4|NM_017458.3	NP_005106.2|NP_059447.2	Q14764	MVP_HUMAN	major vault protein	629					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(7)|ovary(2)|skin(3)|soft_tissue(1)|stomach(1)	27						CTGTCTTCCCCCAAAACGGGC	0.657000													13	145					0	0	1	0	0
ZNF563	147837	broad.mit.edu	37	19	12429458	12429458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12429458G>A	ENST00000293725.5	-	4	1586	c.1381C>T	c.(1381-1383)Ccc>Tcc	p.P461S		NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						CATACACTGGGATAAACAAAG	0.378000													52	109					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32742026	32742026	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32742026T>G	ENST00000333070.4	+	8	820	c.720T>G	c.(718-720)gtT>gtG	p.V240V	LCK_ENST00000336890.5_Silent_p.V240V|LCK_ENST00000373564.3_Intron	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	240	Interaction with PTPRH.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	AGTGGGAGGTTCCCAGGGAGA	0.662000			T	TRB@	T-ALL								13	37					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56949917	56949917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56949917C>T	ENST00000497933.1	+	1	697	c.550C>T	c.(550-552)Cac>Tac	p.H184Y		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	154						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						TGGGCTAGTCCACATCGACCT	0.607000													16	34					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105153049	105153049	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105153049G>A	ENST00000428173.2	+	13	1722	c.1419G>A	c.(1417-1419)cgG>cgA	p.R473R	NRK_ENST00000243300.9_Silent_p.R472R			Q7Z2Y5	NRK_HUMAN	Nik related kinase	472	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						CACGACTACGGAGGGCAGCCA	0.562000										HNSCC(51;0.14)			11	18					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201016711	201016711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201016711C>T	ENST00000362061.3	-	37	4711	c.4485G>A	c.(4483-4485)aaG>aaA	p.K1495K	CACNA1S_ENST00000367338.3_Silent_p.K1476K	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1495					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCCAGATCTTCTTGATGATGG	0.527000													18	58					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16021577	16021577	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16021577G>A	ENST00000350896.3	-	5	1011	c.814C>T	c.(814-816)Caa>Taa	p.Q272*	MSR1_ENST00000445506.2_Nonsense_Mutation_p.Q290*|MSR1_ENST00000536385.1_Nonsense_Mutation_p.Q46*|MSR1_ENST00000381998.4_Nonsense_Mutation_p.Q272*|MSR1_ENST00000262101.5_Nonsense_Mutation_p.Q272*|MSR1_ENST00000355282.2_Nonsense_Mutation_p.Q272*	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	272					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		ATTTTACCTTGAATTAAAGTG	0.294000													15	33					0	0	1	0	0
FPGS	2356	broad.mit.edu	37	9	130569509	130569509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130569509C>T	ENST00000373245.1	+	6	573	c.523C>T	c.(523-525)Ccc>Tcc	p.P175S	FPGS_ENST00000460181.1_3'UTR|FPGS_ENST00000393706.2_Intron|FPGS_ENST00000373247.2_Missense_Mutation_p.P175S|FPGS_ENST00000373225.3_Missense_Mutation_p.P125S			Q05932	FOLC_HUMAN	folylpolyglutamate synthase	175					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)	7					L-Glutamic Acid(DB00142)	TGTCTCCATGCCCCCCTACTT	0.602000													41	109					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29879498	29879498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29879498G>A	ENST00000310624.6	+	2	1051	c.1018G>A	c.(1018-1020)Gac>Aac	p.D340N		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	340	Coil 2B.|Rod.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						AAGCACCAAGGACTCACTGGA	0.612000													26	102					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152394450	152394450	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152394450C>T	ENST00000427231.2	-	140	21240	c.21038G>A	c.(21037-21039)tGg>tAg	p.W7013*	NEB_ENST00000409198.1_Nonsense_Mutation_p.W5312*|NEB_ENST00000397345.3_Nonsense_Mutation_p.W7013*|NEB_ENST00000604864.1_Nonsense_Mutation_p.W7013*|NEB_ENST00000172853.10_Nonsense_Mutation_p.W5312*|NEB_ENST00000603639.1_Nonsense_Mutation_p.W7013*	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	5312					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AATGGACCTCCAGATACCCAA	0.393000													12	38					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86468627	86468627	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:86468627G>A	ENST00000297814.2	-	15	3417	c.3274C>T	c.(3274-3276)Cgt>Tgt	p.R1092C	RP11-575L7.4_ENST00000590368.1_RNA|RP11-575L7.4_ENST00000586206.1_RNA|RP11-575L7.4_ENST00000590813.1_RNA|KIF27_ENST00000413982.1_Missense_Mutation_p.R1026C|KIF27_ENST00000334204.2_Missense_Mutation_p.R995C|RP11-575L7.4_ENST00000589817.1_RNA|RP11-575L7.4_ENST00000591217.1_RNA	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	1092					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						GCTTCACCACGAGAGAGGTTA	0.398000													37	90					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131220670	131220670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:131220670C>T	ENST00000337057.3	-	8	1378	c.1197G>A	c.(1195-1197)aaG>aaA	p.K399K	EPB41L2_ENST00000530148.1_5'UTR|EPB41L2_ENST00000525271.1_Silent_p.K399K|EPB41L2_ENST00000525193.1_Silent_p.K399K|EPB41L2_ENST00000392427.3_Silent_p.K399K|EPB41L2_ENST00000527659.1_Silent_p.K399K|EPB41L2_ENST00000528282.1_Silent_p.K399K|EPB41L2_ENST00000530481.1_Silent_p.K399K|EPB41L2_ENST00000445890.2_Silent_p.K399K|EPB41L2_ENST00000527411.1_Silent_p.K399K|EPB41L2_ENST00000368128.2_Silent_p.K399K|EPB41L2_ENST00000529208.1_Silent_p.K399K	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	399	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TGGAAAGCCTCTTTGCATTTT	0.418000													34	63					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31146148	31146148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31146148G>A	ENST00000304166.4	+	16	1546	c.1257G>A	c.(1255-1257)aaG>aaA	p.K419K	ADCYAP1R1_ENST00000409489.1_Silent_p.K475K|ADCYAP1R1_ENST00000396211.2_Silent_p.K447K|ADCYAP1R1_ENST00000409363.1_Silent_p.K398K	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	419					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						GAAGCTGGAAGGTGAACCGTT	0.592000													25	49					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77274304	77274304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77274304G>A	ENST00000251089.2	-	3	949	c.837C>T	c.(835-837)ttC>ttT	p.F279F		NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	279										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TGAGGTTCACGAAGCGATAGT	0.512000													22	57					0	0	1	0	0
VN1R4	317703	broad.mit.edu	37	19	53770263	53770263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53770263C>T	ENST00000311170.4	-	1	709	c.656G>A	c.(655-657)aGc>aAc	p.S219N		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	219					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GGAGAGATTGCTCCTATCAAT	0.547000										HNSCC(26;0.072)			9	26					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32221810	32221810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32221810G>A	ENST00000373658.3	-	4	969	c.628C>T	c.(628-630)Cgc>Tgc	p.R210C	BAI2_ENST00000398556.3_Missense_Mutation_p.R213C|BAI2_ENST00000373655.2_Missense_Mutation_p.R210C|BAI2_ENST00000257070.4_Missense_Mutation_p.R210C|BAI2_ENST00000398538.1_Missense_Mutation_p.R198C|BAI2_ENST00000527361.1_Missense_Mutation_p.R210C|BAI2_ENST00000398542.1_Missense_Mutation_p.R198C|BAI2_ENST00000398547.1_Missense_Mutation_p.R198C	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	210					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CCGGCAGCGCGGCCACACTCC	0.647000													7	51					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814507	60814507	+	Missense_Mutation	SNP	C	C	T	rs17853369		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60814507C>T	ENST00000544856.2	-	7	1097	c.719G>A	c.(718-720)gGa>gAa	p.G240E	RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.G241E|MARCH10_ENST00000311269.5_Missense_Mutation_p.G241E|MARCH10_ENST00000583600.1_Missense_Mutation_p.G279E|RP11-156L14.1_ENST00000582564.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	241							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						ACTATTTTTTCCTTGGAAGGC	0.532000													48	127					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23225854	23225854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:23225854G>A	ENST00000389131.3	-	2	380	c.11C>T	c.(10-12)cCt>cTt	p.P4L		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	4					aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		GGAGCACAGAGGCCTCTCCAT	0.637000													22	31					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61834025	61834025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61834025G>A	ENST00000280772.1	-	37	6805	c.6614C>T	c.(6613-6615)cCa>cTa	p.P2205L	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2205					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGTGGGCTTTGGTTCCAATTC	0.448000													33	94					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96030073	96030073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96030073G>A	ENST00000297954.4	+	16	3742	c.3742G>A	c.(3742-3744)Gag>Aag	p.E1248K	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.E860K|WNK2_ENST00000349097.3_Missense_Mutation_p.E860K|WNK2_ENST00000395477.2_Missense_Mutation_p.E1248K|WNK2_ENST00000356055.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1248					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						AACGTTCATCGAGCAGATGAA	0.602000													4	18					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101918575	101918575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101918575C>T	ENST00000437600.4	+	17	1854	c.1502C>T	c.(1501-1503)tCc>tTc	p.S501F	CUX1_ENST00000292538.4_Missense_Mutation_p.S503F|CUX1_ENST00000425244.2_Missense_Mutation_p.S457F|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000393824.3_Missense_Mutation_p.S464F|CUX1_ENST00000547394.2_Missense_Mutation_p.S487F	NM_181500.2	NP_852477.1	P39880	CUX1_HUMAN	cut-like homeobox 1	315					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCACTGCTTTCCATCATCTCC	0.642000													30	72					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70928354	70928354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70928354G>A	ENST00000393567.2	-	55	9396	c.9246C>T	c.(9244-9246)ttC>ttT	p.F3082F		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3082										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CCAGTTACCTGAACGCGATCT	0.522000													12	46					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128362842	128362842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:128362842C>T	ENST00000262462.4	+	7	2282	c.1272C>T	c.(1270-1272)ctC>ctT	p.L424L	SLC27A6_ENST00000395266.1_Silent_p.L424L|SLC27A6_ENST00000506176.1_Silent_p.L424L			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	424					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CTGGACTTCTCATTTCTCGAG	0.378000													40	92					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149906993	149906993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149906993G>A	ENST00000439741.2	-	5	604	c.354C>T	c.(352-354)ctC>ctT	p.L118L	MTMR11_ENST00000406732.3_Silent_p.L90L|MTMR11_ENST00000492824.1_5'UTR|MTMR11_ENST00000361405.6_Silent_p.L118L|MTMR11_ENST00000369140.3_Silent_p.L46L	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	118							phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACCCTGGACGGAGGAGCTGGA	0.547000													28	87					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107844633	107844633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107844633G>A	ENST00000328300.6	+	26	2203	c.1959G>A	c.(1957-1959)ggG>ggA	p.G653G	COL4A5_ENST00000361603.2_Silent_p.G653G	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	653	Triple-helical region.		G -> R (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GTCCTAAAGGGGATCCAGGTC	0.403000									Alport syndrome with Diffuse Leiomyomatosis				9	13					0	0	1	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473075	22473075	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22473075C>T	ENST00000557788.2	-	0	195																											CCAATCCACTCCAGCCCCTTC	0.572000													26	233					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158746637	158746637	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158746637C>T	ENST00000339258.1	-	1	788	c.789G>A	c.(787-789)aaG>aaA	p.K263K		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					AATAGCTCTTCTTTAGCCGCA	0.443000													37	77					0	0	1	0	0
NFAM1	150372	broad.mit.edu	37	22	42807591	42807591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42807591C>T	ENST00000329021.5	-	2	310	c.273G>A	c.(271-273)agG>agA	p.R91R		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	91	Ig-like V-type.				B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			large_intestine(1)|lung(3)	4						TCTTAGGGCTCCTCTGTCCCT	0.547000													34	86					0	0	1	0	0
ZRANB2	9406	broad.mit.edu	37	1	71530793	71530793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:71530793G>A	ENST00000370920.3	-	10	1258	c.957C>T	c.(955-957)tcC>tcT	p.S319S	ZRANB2_ENST00000477096.1_5'UTR|ZRANB2_ENST00000254821.6_3'UTR|ZRANB2-AS1_ENST00000450461.1_RNA|ZRANB2-AS1_ENST00000426999.1_RNA	NM_203350.2	NP_976225.1	O95218	ZRAB2_HUMAN	zinc finger, RAN-binding domain containing 2	319	Required for nuclear targeting.				mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|stomach(1)	15						AACCAGAATGGGATGATCCAG	0.348000													7	61					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73464772	73464772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73464772G>A	ENST00000224721.6	+	24	2858	c.2853G>A	c.(2851-2853)gtG>gtA	p.V951V	CDH23_ENST00000299366.7_Silent_p.V991V	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	946	Cadherin 9.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCAGCGGCGTGGTGGTCACCA	0.667000													39	85					0	0	1	0	0
ECSIT	51295	broad.mit.edu	37	19	11624842	11624842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11624842C>T	ENST00000270517.7	-	3	426	c.291G>A	c.(289-291)gcG>gcA	p.A97A	ECSIT_ENST00000592312.1_5'UTR|ECSIT_ENST00000591104.1_Silent_p.A97A|ECSIT_ENST00000252440.7_Silent_p.A97A|ECSIT_ENST00000588998.1_Intron|ECSIT_ENST00000417981.2_Intron	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	97					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						CGCTGTGCTCCGCAAATTTCT	0.622000													18	58					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76573651	76573651	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:76573651C>T	ENST00000307431.8	+	21	3638	c.3253C>T	c.(3253-3255)Caa>Taa	p.Q1085*	CNTNAP4_ENST00000377504.4_Nonsense_Mutation_p.Q1037*|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Nonsense_Mutation_p.Q1089*|CNTNAP4_ENST00000478060.1_Nonsense_Mutation_p.Q1013*	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1086	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AAATAAATATCAAGAGCCTGA	0.343000													22	40					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56190114	56190114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56190114C>T	ENST00000340462.4	-	3	542	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	ZBP1_ENST00000343535.4_Missense_Mutation_p.E111K|ZBP1_ENST00000371173.3_Missense_Mutation_p.E111K|ZBP1_ENST00000541799.1_Missense_Mutation_p.E111K|ZBP1_ENST00000395822.3_Missense_Mutation_p.E36K|ZBP1_ENST00000538947.1_5'UTR			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	111			E -> K (in dbSNP:rs2073145).			cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			TAGATGTCTTCCTCTGGgagg	0.572000													28	136					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137681046	137681046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137681046G>A	ENST00000371817.3	+	32	3106	c.2692G>A	c.(2692-2694)Ggc>Agc	p.G898S		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	898	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGGAGAGAAGGGCGGCAGGGT	0.572000													15	22					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14766126	14766126	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14766126C>T	ENST00000261170.3	-	27	3283	c.3147G>A	c.(3145-3147)cgG>cgA	p.R1049R	RP11-695J4.2_ENST00000545424.1_RNA|RP11-695J4.2_ENST00000542401.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	1049					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AGCTGGCTACCCGTCTGGGTT	0.433000													68	250					0	0	1	0	0
GGTLC2	91227	broad.mit.edu	37	22	22989517	22989517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22989517G>A	ENST00000448514.1	+	3	369	c.369G>A	c.(367-369)atG>atA	p.M123I	GGTLC2_ENST00000480559.1_Intron			Q14390	GGTL2_HUMAN	gamma-glutamyltransferase light chain 2	120					glutathione biosynthetic process		gamma-glutamyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		AGGTCCGGATGGTGGTGGGAG	0.642000													30	90					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390859	197390859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197390859C>T	ENST00000367397.1	+	2	902	c.44C>T	c.(43-45)cCa>cTa	p.P15L	CRB1_ENST00000535699.1_Missense_Mutation_p.P565L|CRB1_ENST00000543483.1_Intron|CRB1_ENST00000367400.3_Missense_Mutation_p.P634L|CRB1_ENST00000538660.1_Missense_Mutation_p.P634L|CRB1_ENST00000544212.1_Missense_Mutation_p.P115L|CRB1_ENST00000367399.2_Missense_Mutation_p.P522L			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	634					cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TATAATATGCCATCCACACCT	0.408000													54	149					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43579536	43579536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43579536G>A	ENST00000406487.1	-	3	777	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	227	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region		p.R227C(1)		central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GGGTCACTGCGGCTGGCACTC	0.527000													39	447					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76463724	76463724	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:76463724C>T	ENST00000396423.2	+	4	578	c.454C>T	c.(454-456)Cgc>Tgc	p.R152C	HNF4G_ENST00000354370.1_Missense_Mutation_p.R115C	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	115					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			AGTTCGGTCTCGCCAGGTACC	0.423000													9	34					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49699167	49699167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49699167G>A	ENST00000296452.4	+	6	10003	c.9889G>A	c.(9889-9891)Gat>Aat	p.D3297N		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3297					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGACTCATACGATCCCCGCGG	0.612000													23	58					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676400	65676400	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65676400G>A	ENST00000352385.2	-	20	3909	c.3700C>T	c.(3700-3702)Cct>Tct	p.P1234S	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1234						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GCTCCTAGAGGGCAGGGGGAT	0.632000													7	24					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23872985	23872985	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23872985C>T	ENST00000405093.3	-	9	808	c.738G>A	c.(736-738)ggG>ggA	p.G246G	MYH6_ENST00000356287.3_Silent_p.G246G	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	246	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TAATGAATTTCCCCTGGGGAC	0.567000													6	17					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179529611	179529611	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179529611G>A	ENST00000589042.1	-	166	36310	c.36086C>T	c.(36085-36087)cCt>cTt	p.P12029L	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10177	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTTGGAAGGAACTGTCTT	0.373000													5	22					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814126	123814126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123814126G>A	ENST00000321252.2	-	1	454	c.420C>T	c.(418-420)gtC>gtT	p.V140V		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V140V(1)		breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTTGGGAACAGACATGGCCAT	0.567000													12	18					0	0	1	0	0
KCNIP3	30818	broad.mit.edu	37	2	96040113	96040113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96040113C>T	ENST00000295225.5	+	3	386	c.251C>T	c.(250-252)gCc>gTc	p.A84V	KCNIP3_ENST00000468529.1_Missense_Mutation_p.A58V|KCNIP3_ENST00000377181.2_3'UTR|KCNIP3_ENST00000360990.3_Missense_Mutation_p.A84V	NM_013434.4	NP_038462.1	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3, calsenilin	84	EF-hand 1; degenerate.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	16				READ - Rectum adenocarcinoma(193;0.13)		CAGCTGCAGGCCCAGACCAAG	0.602000													16	58					0	0	1	0	0
PPM1A	5494	broad.mit.edu	37	14	60712655	60712655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:60712655G>A	ENST00000325642.3	+	1	186	c.90G>A	c.(88-90)agG>agA	p.R30R	CTD-2184C24.2_ENST00000529171.1_RNA|PPM1A_ENST00000529574.1_5'UTR	NM_177952.2	NP_808821.2	P35813	PPM1A_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1A	87					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.046)		ggaagagaagggcaaagaagg	0.398000													3	11					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22892237	22892237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22892237G>A	ENST00000543184.1	-	4	1726	c.864C>T	c.(862-864)ttC>ttT	p.F288F	PRAME_ENST00000402697.1_Silent_p.F288F|PRAME_ENST00000539862.1_Silent_p.F272F|PRAME_ENST00000405655.3_Silent_p.F288F|PRAME_ENST00000424204.2_Silent_p.F272F|PRAME_ENST00000398743.2_Silent_p.F288F|PRAME_ENST00000398741.1_Silent_p.F288F	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	288					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		ACTGAGAGGTGAACTGGGCGA	0.522000													27	66					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28519449	28519449	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28519449G>A	ENST00000261609.7	-	7	896	c.788C>T	c.(787-789)tCc>tTc	p.S263F		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	263					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGTCACGACGGACCTGAGGAA	0.592000													14	28					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7708370	7708370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7708370C>T	ENST00000572933.1	+	60	10738	c.9278C>T	c.(9277-9279)cCc>cTc	p.P3093L	DNAH2_ENST00000389173.2_Missense_Mutation_p.P3093L			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3093	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GAGGCACTGCCCGCCCTGGAA	0.587000													45	48					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95403849	95403849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95403849G>A	ENST00000336148.5	-	10	1921	c.1797C>T	c.(1795-1797)ttC>ttT	p.F599F		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			TTATAGAGTTGAACAAAAGGC	0.408000								Direct reversal of damage;Homologous recombination					58	136					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234452365	234452365	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:234452365C>T	ENST00000366618.3	+	5	991	c.846C>T	c.(844-846)ctC>ctT	p.L282L	SLC35F3_ENST00000366617.3_Silent_p.L213L	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	213					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CCGCCATCCTCGCCATCGCTG	0.577000													148	370					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724972	49724972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49724972C>T	ENST00000551245.1	+	13	2455	c.2344C>T	c.(2344-2346)Cct>Tct	p.P782S	TROAP_ENST00000257909.3_Intron|TROAP_ENST00000547923.1_Intron			Q12815	TROAP_HUMAN	trophinin associated protein	0					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						CCCAGACCTCCCTCTAAATTT	0.582000													12	27					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91809811	91809811	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91809811G>A	ENST00000394232.1	+	7	1478		c.e7-1		SV2B_ENST00000330276.4_Splice_Site|SV2B_ENST00000545111.2_Splice_Site	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B						neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTACTTTTCAGGTTTCCAACA	0.373000													18	69					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619434	57619434	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57619434C>T	ENST00000349394.5	+	2	1006	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	277	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						TCAAAGTCATCTGTATCTTCG	0.572000													16	68					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156882382	156882382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156882382C>T	ENST00000338302.3	+	18	2402	c.2177C>T	c.(2176-2178)cCc>cTc	p.P726L	PEAR1_ENST00000292357.7_Missense_Mutation_p.P726L			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	726						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGTGTATGTCCCCCAGGGCAC	0.602000													21	55					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36845839	36845839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36845839G>A	ENST00000279024.4	-	13	2988	c.2717C>T	c.(2716-2718)gCc>gTc	p.A906V		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	906										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CAGCTGAGCGGCCTGCTTGGA	0.692000													8	19					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182852338	182852338	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:182852338C>T	ENST00000367549.3	+	25	3089	c.2979C>T	c.(2977-2979)tcC>tcT	p.S993S	DHX9_ENST00000485081.1_3'UTR	NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	993					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						TTGTTATCTCCCTCCTGGCCT	0.398000													38	113					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70455136	70455136	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70455136G>A	ENST00000503640.1	-	6	1593	c.1538C>T	c.(1537-1539)tCc>tTc	p.S513F	UGT2A1_ENST00000512704.1_Missense_Mutation_p.S469F|UGT2A2_ENST00000457664.2_Missense_Mutation_p.S522F|UGT2A1_ENST00000514019.1_Missense_Mutation_p.S679F|UGT2A1_ENST00000286604.4_Missense_Mutation_p.S513F	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	513					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						TTTTTGACAGGAAAACAAACA	0.353000													23	62					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186459360	186459360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186459360G>A	ENST00000265023.4	+	10	1387	c.1175G>A	c.(1174-1176)cGa>cAa	p.R392Q	KNG1_ENST00000287611.2_Missense_Mutation_p.R392Q|KNG1_ENST00000447445.1_Missense_Mutation_p.R356Q|RP11-573D15.8_ENST00000599314.1_RNA|RP11-573D15.8_ENST00000354642.2_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	392					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CGATCATCACGAATAGGGGAA	0.403000													18	105					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89941791	89941791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89941791G>A	ENST00000405460.2	+	16	3001	c.2905G>A	c.(2905-2907)Gaa>Aaa	p.E969K		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	969	Calx-beta 7.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAAGATTCCAGAAGAAATGGA	0.323000													9	32					0	0	1	0	0
ASF1B	55723	broad.mit.edu	37	19	14247214	14247214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14247214G>A	ENST00000263382.3	-	1	554	c.55C>T	c.(55-57)Cac>Tac	p.H19Y	ASF1B_ENST00000474890.1_Missense_Mutation_p.H19Y|ASF1B_ENST00000592798.1_Missense_Mutation_p.H19Y	NM_018154.2	NP_060624.1	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B histone chaperone	19	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus				endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	7						AAGGGGCTGTGGAAAGGGCTC	0.716000													13	43					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024477	55024477	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:55024477C>T	ENST00000324000.3	+	3	2670	c.636C>T	c.(634-636)ccC>ccT	p.P212P		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	212					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CCTTCAACCCCAGCATCCTGG	0.398000													31	103					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43310378	43310378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43310378C>T	ENST00000321925.4	+	3	325	c.93C>T	c.(91-93)ttC>ttT	p.F31F	SLC14A1_ENST00000502059.2_Intron|SLC14A1_ENST00000586142.1_Silent_p.F31F|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000436407.3_Silent_p.F87F|SLC14A1_ENST00000402943.2_Intron|SLC14A1_ENST00000535474.1_Intron|SLC14A1_ENST00000415427.3_Silent_p.F87F|SLC14A1_ENST00000589700.1_Silent_p.F31F|SLC14A1_ENST00000591943.1_3'UTR	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	31						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						GAAGGTGCTTCCCCAAAGCTC	0.488000													32	84					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481842	140481842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140481842G>A	ENST00000231130.2	+	1	1609	c.1609G>A	c.(1609-1611)Ggc>Agc	p.G537S		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		537	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACAGACCGTGGCTCCCCGGC	0.677000													36	93					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86270675	86270675	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86270675C>T	ENST00000394518.2	+	29	7163	c.7068C>T	c.(7066-7068)acC>acT	p.T2356T	AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Silent_p.T2360T|AKAP13_ENST00000394510.2_Silent_p.T601T	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2356	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TGTTGGACACCAGAGCCCGAG	0.438000													21	93					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219874711	219874711	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219874711C>T	ENST00000341552.5	-	27	4488	c.4405G>A	c.(4405-4407)Gag>Aag	p.E1469K	CCDC108_ENST00000441968.1_Missense_Mutation_p.E1469K|AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000453220.1_Missense_Mutation_p.E1469K	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1469						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAATTTCCTCGTTCTTGGAG	0.532000													11	48					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77779516	77779516	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:77779516G>A	ENST00000407578.2	-	26	3984	c.3718C>T	c.(3718-3720)Cat>Tat	p.H1240Y	MYCBP2_ENST00000357337.6_Missense_Mutation_p.H1202Y|MYCBP2_ENST00000544440.2_Missense_Mutation_p.H1202Y|MYCBP2_ENST00000360084.5_5'UTR	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CCTCCTCCATGACCTAGAATA	0.368000													31	63					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90498113	90498113	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90498113G>A	ENST00000325643.5	+	1	373	c.307G>A	c.(307-309)Gag>Aag	p.E103K		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		GAGCAGCAGGGAGGTAAGGAG	0.557000													4	7					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42457418	42457418	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42457418G>A	ENST00000381668.5	-	29	2944	c.2713C>T	c.(2713-2715)Cct>Tct	p.P905S	ATP8A1_ENST00000264449.10_Missense_Mutation_p.P890S	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	905					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	AGAGTTAAAGGAGGCATTGCT	0.398000													31	92					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286638	152286638	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152286638C>T	ENST00000368799.1	-	3	759	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	242					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCATAGGCTTCATCCTGGATT	0.353000									Ichthyosis				46	123					0	0	1	0	0
ATF2	1386	broad.mit.edu	37	2	175939542	175939542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:175939542G>A	ENST00000264110.2	-	14	1611	c.1313C>T	c.(1312-1314)tCa>tTa	p.S438L	ATF2_ENST00000392544.1_Missense_Mutation_p.S438L|ATF2_ENST00000426833.3_Missense_Mutation_p.S420L|ATF2_ENST00000487334.2_3'UTR|ATF2_ENST00000345739.5_Missense_Mutation_p.S380L|ATF2_ENST00000409437.1_Missense_Mutation_p.S322L|ATF2_ENST00000538946.1_3'UTR|ATF2_ENST00000409499.1_Missense_Mutation_p.S77L|ATF2_ENST00000392543.2_Missense_Mutation_p.S59L|ATF2_ENST00000409635.1_Missense_Mutation_p.S380L	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	438					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			AATGTCTTCTGAACTATCATC	0.418000													17	52					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138713428	138713428	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138713428G>A	ENST00000389532.4	-	11	3143	c.3079C>T	c.(3079-3081)Ctt>Ttt	p.L1027F	CAMSAP1_ENST00000312405.6_Missense_Mutation_p.L749F|CAMSAP1_ENST00000483991.1_5'UTR|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.L1038F	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	1027						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GTTTCGTTAAGCTTCTCGATG	0.542000													18	34					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433090	55433090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55433090G>A	ENST00000314259.3	+	1	477	c.448G>A	c.(448-450)Gga>Aga	p.G150R		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TTGGGTGGGGGGATTTATGCA	0.468000													21	94					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175334383	175334383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175334383G>A	ENST00000367674.1	-	12	3058	c.2350C>T	c.(2350-2352)Cat>Tat	p.H784Y	TNR_ENST00000263525.2_Missense_Mutation_p.H784Y	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	784	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GAGGTCACATGAGAAAAGTGC	0.507000													16	32					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497337	141497337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141497337C>T	ENST00000264952.2	+	1	348	c.211C>T	c.(211-213)Cgt>Tgt	p.R71C		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	71	RGS.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CCGCCTCTTCCGTGACTTCCT	0.662000													15	22					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1684132	1684132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1684132C>T	ENST00000252804.4	-	7	613	c.563G>A	c.(562-564)cGa>cAa	p.R188Q		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	188					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TGAGTCCAGTCGCCTGTGGGA	0.592000													16	32					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104432603	104432603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:104432603C>T	ENST00000297579.5	+	2	915	c.638C>T	c.(637-639)tCg>tTg	p.S213L	DCAF13_ENST00000521716.1_Missense_Mutation_p.S57L|DCAF13_ENST00000521971.1_Missense_Mutation_p.S57L|DCAF13_ENST00000519682.1_Missense_Mutation_p.S57L|DCAF13_ENST00000521999.1_Intron	NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	61					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						TTCCTTGCTTCGCTGGATGGT	0.458000													23	45					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76752151	76752151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76752151G>A	ENST00000575389.2	+	2	160	c.160G>A	c.(160-162)Gag>Aag	p.E54K	SALL3_ENST00000536229.3_5'UTR|SALL3_ENST00000572928.1_3'UTR|SALL3_ENST00000537592.2_Missense_Mutation_p.E54K			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CAGCGTGTGCGAGAAATGCTG	0.687000													5	18					0	0	1	0	0
OR1J1	347168	broad.mit.edu	37	9	125239244	125239244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125239244C>T	ENST00000259357.2	-	1	991	c.962G>A	c.(961-963)gGa>gAa	p.G321E		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	321					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						gcctcagcctcccaaagtgtt	0.468000													13	33					0	0	1	0	0
C2orf42	54980	broad.mit.edu	37	2	70387902	70387902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70387902G>A	ENST00000264434.2	-	9	1750	c.1371C>T	c.(1369-1371)acC>acT	p.T457T	C2orf42_ENST00000420306.1_Silent_p.T457T	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	457										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						TAAAGCTACGGGTGATTTCCA	0.403000													17	45					0	0	1	0	0
H2BFM	286436	broad.mit.edu	37	X	103294884	103294884	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:103294884C>T	ENST00000243297.5	+	3	650	c.650C>T	c.(649-651)tCc>tTc	p.S217F	H2BFM_ENST00000355016.3_Missense_Mutation_p.S114F					H2B histone family, member M											endometrium(1)|lung(1)|ovary(1)	3						ACCATCACCTCCCGGGACATC	0.617000													5	5					0	0	1	0	0
PPP6R1	22870	broad.mit.edu	37	19	55750817	55750817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55750817G>A	ENST00000412770.2	-	15	2273	c.1707C>T	c.(1705-1707)ttC>ttT	p.F569F	PPP6R1_ENST00000587283.1_Silent_p.F569F	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	569					regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						CATTGAAGCCGAAGTGGTCAA	0.612000													5	19					0	0	1	0	0
RNASE11	122651	broad.mit.edu	37	14	21052444	21052444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21052444G>A	ENST00000335950.4	-	3	652	c.190C>T	c.(190-192)Ctc>Ttc	p.L64F	RNASE11_ENST00000432835.2_Missense_Mutation_p.L64F|RNASE11_ENST00000398008.2_Missense_Mutation_p.L64F|RNASE11_ENST00000555841.1_Missense_Mutation_p.L64F|RNASE11_ENST00000398009.2_Missense_Mutation_p.L64F|RNASE11_ENST00000553849.1_Missense_Mutation_p.L64F	NM_145250.3	NP_660293.1	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	64						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(6)|lung(7)|ovary(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	21	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		GACATGCTGAGGCTGGTATTT	0.393000													90	258					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29104780	29104780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29104780G>A	ENST00000261590.8	+	8	1152	c.943G>A	c.(943-945)Gga>Aga	p.G315R		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	315	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			ATTTGCATCAGGAAATGAAGG	0.368000													12	79					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511765	61511765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61511765G>A	ENST00000266070.4	-	16	5868	c.5543C>T	c.(5542-5544)cCc>cTc	p.P1848L	DIDO1_ENST00000395343.1_Missense_Mutation_p.P1848L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1848	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CTCCCCATGGGGATCCTTGCG	0.607000													13	117					0	0	1	0	0
EPSTI1	94240	broad.mit.edu	37	13	43463358	43463358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43463358C>T	ENST00000313640.7	-	12	1033	c.969G>A	c.(967-969)tcG>tcA	p.S323S	EPSTI1_ENST00000398762.3_Intron|EPSTI1_ENST00000313624.7_Intron	NM_001002264.2	NP_001002264.1	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 (breast)	0										endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|skin(1)	17		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		TTAGGTGCCTCGAAAAAACTA	0.294000													21	42					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29632657	29632657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:29632657G>A	ENST00000278882.3	+	8	852	c.472G>A	c.(472-474)Gaa>Aaa	p.E158K	FRG1B_ENST00000358464.4_Missense_Mutation_p.E158K																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATAAGTAAAGAAGAGAGTAA	0.308000													39	970					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212537927	212537927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:212537927C>T	ENST00000342788.4	-	14	1988	c.1678G>A	c.(1678-1680)Gag>Aag	p.E560K	ERBB4_ENST00000436443.1_Missense_Mutation_p.E560K|ERBB4_ENST00000402597.1_Missense_Mutation_p.E560K	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	560	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCATCTTCTCACACTGGGGG	0.463000										TSP Lung(8;0.080)			21	52					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138651571	138651571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138651571C>T	ENST00000298480.5	+	11	975	c.901C>T	c.(901-903)Ctc>Ttc	p.L301F	KCNT1_ENST00000487664.1_Missense_Mutation_p.L256F|KCNT1_ENST00000491806.2_Missense_Mutation_p.L268F|KCNT1_ENST00000371757.2_Missense_Mutation_p.L301F|KCNT1_ENST00000490355.2_Missense_Mutation_p.L282F|KCNT1_ENST00000263604.3_Missense_Mutation_p.L282F|KCNT1_ENST00000488444.2_Missense_Mutation_p.L282F|KCNT1_ENST00000486577.2_Missense_Mutation_p.L262F			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	301						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GAACCTGTCCCTCCTGACCTC	0.667000													11	41					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110465872	110465872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110465872C>T	ENST00000329608.6	+	6	1020	c.629C>T	c.(628-630)cCc>cTc	p.P210L	CSF1_ENST00000420111.2_Intron|CSF1_ENST00000369802.3_Missense_Mutation_p.P210L|CSF1_ENST00000344188.5_Missense_Mutation_p.P210L|CSF1_ENST00000369801.1_Missense_Mutation_p.P210L	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	210					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCTCATCAGCCCCTCGCCCCC	0.617000											OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	103					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862740	14862740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14862740C>T	ENST00000285046.5	+	1	2272	c.2162C>T	c.(2161-2163)tCc>tTc	p.S721F	FGD5_ENST00000543601.1_Missense_Mutation_p.S480F	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	721					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TCCCCCTCCTCCCTCATCTTT	0.582000													25	61					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158299230	158299230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158299230C>T	ENST00000368168.3	-	4	923	c.816G>A	c.(814-816)ggG>ggA	p.G272G		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	272	Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					CAGCCGCCTCCCCATCTGCCA	0.587000													24	84					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160755484	160755484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160755484C>T	ENST00000263636.4	-	2	208	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	LY75-CD302_ENST00000505052.1_Missense_Mutation_p.E61K|LY75_ENST00000553424.1_Missense_Mutation_p.E61K|LY75_ENST00000554112.1_Missense_Mutation_p.E61K|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.E61K	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TCCTCAGTTTCATCACAGTCG	0.478000													17	117					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408375	29408375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29408375G>A	ENST00000444197.2	+	1	1293	c.583G>A	c.(583-585)Gaa>Aaa	p.E195K	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CTCGCTTAATGAACTGCAGAT	0.562000													71	143					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6661841	6661841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6661841C>T	ENST00000299441.3	-	2	1415	c.1004G>A	c.(1003-1005)cGa>cAa	p.R335Q		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	335	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCACCATCTCGTGCTTGCAC	0.587000													50	80					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206580936	206580936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206580936C>T	ENST00000360409.3	+	3	1062	c.271C>T	c.(271-273)Cgg>Tgg	p.R91W	NRP2_ENST00000540178.1_Missense_Mutation_p.R91W|NRP2_ENST00000357785.5_Missense_Mutation_p.R91W|NRP2_ENST00000412873.2_Missense_Mutation_p.R91W|NRP2_ENST00000417189.1_Missense_Mutation_p.R91W|NRP2_ENST00000272849.3_Missense_Mutation_p.R91W|NRP2_ENST00000355117.4_Missense_Mutation_p.R91W|NRP2_ENST00000540841.1_Missense_Mutation_p.R91W|NRP2_ENST00000357118.4_Missense_Mutation_p.R91W	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	91	CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						TATCGAGATTCGGGATGGGGA	0.542000													49	112					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41664893	41664893	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41664893G>A	ENST00000313860.7	+	15	2082	c.2028G>A	c.(2026-2028)gtG>gtA	p.V676V	LIMCH1_ENST00000381753.4_Silent_p.V510V|LIMCH1_ENST00000513024.1_Silent_p.V505V|LIMCH1_ENST00000508501.1_Silent_p.V676V|LIMCH1_ENST00000512946.1_Silent_p.V676V|LIMCH1_ENST00000509277.1_Silent_p.V510V|LIMCH1_ENST00000511496.1_Silent_p.V517V|LIMCH1_ENST00000512820.1_Silent_p.V664V|LIMCH1_ENST00000503057.1_Silent_p.V1061V|LIMCH1_ENST00000512632.1_Silent_p.V676V|LIMCH1_ENST00000514096.1_Silent_p.V517V|LIMCH1_ENST00000396595.3_Silent_p.V522V	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	676					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TGGCCTTTGTGGAATTTCCCT	0.458000													12	98					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443492	5443492	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5443492G>A	ENST00000300778.4	+	1	152	c.62G>A	c.(61-63)gGa>gAa	p.G21E	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GACATCCCTGGATTTGAGGCC	0.502000													47	156					0	0	1	0	0
CYP27A1	1593	broad.mit.edu	37	2	219679167	219679167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219679167C>T	ENST00000258415.4	+	7	1676	c.1249C>T	c.(1249-1251)Ctc>Ttc	p.L417F		NM_000784.3	NP_000775.1	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A, polypeptide 1	417					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(3)|urinary_tract(1)	26		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	TGATGGCTTCCTCTTCCCCAA	0.522000													40	94					0	0	1	0	0
FGF1	2246	broad.mit.edu	37	5	141993537	141993537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141993537C>T	ENST00000359370.6	-	2	235	c.156G>A	c.(154-156)agG>agA	p.R52R	FGF1_ENST00000419524.2_Silent_p.R52R|FGF1_ENST00000378046.1_Silent_p.R52R|FGF1_ENST00000407758.1_Silent_p.R52R|AC005592.2_ENST00000414314.1_RNA|FGF1_ENST00000494579.1_Intron|FGF1_ENST00000337706.2_Silent_p.R52R|AC005592.2_ENST00000443800.1_RNA|FGF1_ENST00000360966.5_Silent_p.R52R	NM_000800.4|NM_001144892.2|NM_001144934.1|NM_001144935.1|NM_001257205.1|NM_001257206.1|NM_001257207.1|NM_001257210.1|NM_001257212.1|NM_033137.2	NP_000791.1|NP_001138364.1|NP_001138406.1|NP_001138407.1|NP_001244134.1|NP_001244135.1|NP_001244136.1|NP_001244139.1|NP_001244141.1|NP_149128.1	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic)	52					angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding			large_intestine(1)|lung(2)	3		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	GCTGGTCGCTCCTGTCCCTTG	0.537000													7	57					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219896315	219896315	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219896315G>A	ENST00000341552.5	-	7	794	c.711C>T	c.(709-711)gcC>gcT	p.A237A	CCDC108_ENST00000409865.3_Silent_p.A226A|CCDC108_ENST00000441968.1_Silent_p.A237A|CCDC108_ENST00000410037.1_Silent_p.A172A|CCDC108_ENST00000453220.1_Silent_p.A237A	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	237						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGGCAGGGTGGCCCGTAGGC	0.607000													33	121					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108363052	108363052	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108363052C>T	ENST00000361582.3	+	14	1413	c.1183C>T	c.(1183-1185)Cat>Tat	p.H395Y	DZIP3_ENST00000463306.1_Missense_Mutation_p.H395Y	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	395					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TTATTTCTATCATCTGCTTCA	0.303000													24	67					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999275	27999275	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27999275G>A	ENST00000441525.1	-	1	291	c.177C>T	c.(175-177)ttC>ttT	p.F59F		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	59										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						CATCGTTCAGGAAACCACCAT	0.507000													25	26					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56382215	56382215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56382215G>A	ENST00000301295.6	+	7	2799	c.2377G>A	c.(2377-2379)Gag>Aag	p.E793K	NLRP4_ENST00000346986.5_Missense_Mutation_p.E737K|NLRP4_ENST00000587891.1_Missense_Mutation_p.E718K	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	793							ATP binding	p.E793K(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCACCTCAGCGAGCAGTGCTG	0.493000													21	55					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59271314	59271314	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:59271314C>T	ENST00000320743.3	-	15	2690	c.2404G>A	c.(2404-2406)Gat>Aat	p.D802N	LRIG3_ENST00000379141.4_Missense_Mutation_p.D742N	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	802						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			CATCCGTCATCGTCTAACGAT	0.572000			T	ROS1	NSCLC								21	40					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40139745	40139745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40139745G>A	ENST00000325157.6	-	7	2013	c.1763C>T	c.(1762-1764)tCa>tTa	p.S588L		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	588										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					GCTTATTTGTGAACTATTCAG	0.413000													26	67					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	629880	629880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:629880G>A	ENST00000230449.4	-	4	512	c.377C>T	c.(376-378)cCc>cTc	p.P126L	EXOC2_ENST00000448181.3_Intron	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	126					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TAAGGACAAGGGCGGAATTCC	0.408000													26	91					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169623443	169623443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:169623443C>T	ENST00000366787.3	-	19	3150	c.2901G>A	c.(2899-2901)ttG>ttA	p.L967L	XXyac-YX65C7_A.2_ENST00000444188.1_RNA|THBS2_ENST00000488355.1_5'UTR	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	967	TSP C-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CTTTGGGATCCAAGGGGACCA	0.498000													20	41					0	0	1	0	0
TMEM8A	58986	broad.mit.edu	37	16	426755	426755	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:426755G>A	ENST00000431232.2	-	5	853	c.693C>T	c.(691-693)tcC>tcT	p.S231S	TMEM8A_ENST00000250930.3_Silent_p.S38S	NM_021259.2	NP_067082.2	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A	231					cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						GGCTCCCATTGGACACGCAGT	0.667000													4	27					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61742998	61742998	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:61742998C>T	ENST00000423902.2	+	15	4119	c.3640C>T	c.(3640-3642)Cag>Tag	p.Q1214*	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1214			Q -> R (in CHARGES).		central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AACAAACATTCAGAAGAAATA	0.378000													39	109					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179497087	179497087	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179497087C>T	ENST00000589042.1	-	236	43758	c.43534G>A	c.(43534-43536)Gaa>Aaa	p.E14512K	TTN_ENST00000342992.6_Missense_Mutation_p.E11944K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E5447K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E5639K|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E5572K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E12871K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12871							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGCACTTTCCTTCTCTTTG	0.403000													9	12					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112020521	112020521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112020521G>A	ENST00000374566.3	-	7	1205	c.688C>T	c.(688-690)Cgg>Tgg	p.R230W	EPB41L4B_ENST00000374557.4_Missense_Mutation_p.R230W	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	230	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGAATGAACCGAAACTCAGAC	0.443000													12	65					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40433618	40433618	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:40433618G>A	ENST00000301825.3	+	3	263	c.145G>A	c.(145-147)Gag>Aag	p.E49K	ENTPD3_ENST00000445129.1_Missense_Mutation_p.E49K|ENTPD3-AS1_ENST00000425156.1_RNA|ENTPD3_ENST00000456402.1_Missense_Mutation_p.E49K|ENTPD3-AS1_ENST00000452768.1_RNA|ENTPD3-AS1_ENST00000439293.1_RNA	NM_001248.2	NP_001239.2	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase 3	49						integral to membrane	ATP binding|hydrolase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		CCACAAGCAAGAGGTCCTCCC	0.468000													24	84					0	0	1	0	0
OR8K1	390157	broad.mit.edu	37	11	56113718	56113718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56113718C>T	ENST00000279783.2	+	1	298	c.204C>T	c.(202-204)ttC>ttT	p.F68F		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F68F(1)		large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TGTACTTTTTCCTTAGACATT	0.408000										HNSCC(65;0.19)			45	144					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149753822	149753822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149753822C>T	ENST00000451292.1	+	8	1064	c.956C>T	c.(955-957)cCc>cTc	p.P319L	TCOF1_ENST00000513346.1_Missense_Mutation_p.P319L|TCOF1_ENST00000323668.7_Missense_Mutation_p.P242L|TCOF1_ENST00000504761.2_Missense_Mutation_p.P319L|TCOF1_ENST00000394269.3_Missense_Mutation_p.P319L|TCOF1_ENST00000377797.3_Missense_Mutation_p.P319L|TCOF1_ENST00000439160.2_Missense_Mutation_p.P319L|TCOF1_ENST00000445265.2_Missense_Mutation_p.P242L			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	319					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCCCAGCACCCCCTGGGAAG	0.597000													4	13					0	0	1	0	0
OR2AE1	81392	broad.mit.edu	37	7	99473921	99473921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99473921C>T	ENST00000316368.2	-	1	759	c.736G>A	c.(736-738)Gtg>Atg	p.V246M		NM_001005276.1	NP_001005276.1	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE, member 1	246					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)	11	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGAGAAACCACCGTGAGGTGG	0.478000													38	85					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183713541	183713541	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183713541C>T	ENST00000511685.1	+	26	5839	c.5716C>T	c.(5716-5718)Cga>Tga	p.R1906*	TENM3_ENST00000406950.2_Nonsense_Mutation_p.R1906*					teneurin transmembrane protein 3																		GCAGACCATCCGATCCATTGG	0.542000													22	53					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133787240	133787240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133787240G>A	ENST00000372338.4	-	5	1127	c.885C>T	c.(883-885)ttC>ttT	p.F295F	FIBCD1_ENST00000253018.4_Silent_p.F137F|FIBCD1_ENST00000448616.1_Silent_p.F295F|FIBCD1_ENST00000372337.2_Silent_p.F137F	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	295	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		AGCCCCGGAAGAAGTTCACGG	0.677000													5	8					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101679563	101679563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101679563C>T	ENST00000261637.4	+	4	404	c.230C>T	c.(229-231)tCa>tTa	p.S77L		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	77					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						AAATGCCAATCATTCAATCAG	0.358000													36	85					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39696876	39696876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:39696876G>A	ENST00000395670.3	-	35	5044	c.4625C>T	c.(4624-4626)cCt>cTt	p.P1542L	KIF21A_ENST00000544797.2_Missense_Mutation_p.P1504L|KIF21A_ENST00000541463.2_Missense_Mutation_p.P1488L|KIF21A_ENST00000361961.3_Missense_Mutation_p.P1528L|KIF21A_ENST00000361418.5_Missense_Mutation_p.P1541L			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1541					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				ATCATAATGAGGGGGTTCAAA	0.388000													10	119					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167162335	167162335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167162335C>T	ENST00000375387.4	-	5	906	c.566G>A	c.(565-567)tGg>tAg	p.W189*	SCN9A_ENST00000409672.1_Nonsense_Mutation_p.W188*|SCN9A_ENST00000409435.1_Nonsense_Mutation_p.W188*|SCN9A_ENST00000303354.6_Nonsense_Mutation_p.W189*			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	188						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CAGCCAGTTCCACGGGTCACG	0.373000													20	62					0	0	1	0	0
ZNF8	7554	broad.mit.edu	37	19	58805887	58805887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58805887C>T	ENST00000196548.5	+	4	844	c.713C>T	c.(712-714)tCc>tTc	p.S238F	AC010642.1_ENST00000591325.1_3'UTR	NM_021089.2	NP_066575.2	P17098	ZNF8_HUMAN	zinc finger protein 8	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	19		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		CACAGAGATTCCAGTCAGGCC	0.478000													15	59					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54867965	54867965	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54867965C>T	ENST00000391743.3	-	6	852	c.572_splice	c.e6+1	p.R191_splice	LAIR1_ENST00000391742.2_Splice_Site_p.R209_splice|LAIR1_ENST00000434277.2_Splice_Site_p.R208_splice|LAIR1_ENST00000313038.6_Splice_Site_p.R202_splice|LAIR1_ENST00000348231.4_Splice_Site_p.R192_splice|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000474878.1_Splice_Site_p.R191_splice			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	209						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		GGGGCCTCACCTCTGCTGTGG	0.592000													13	107					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113105810	113105810	+	Silent	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113105810C>G	ENST00000316851.7	+	13	1719	c.1719C>G	c.(1717-1719)gcC>gcG	p.A573A	NCAM1_ENST00000401611.2_Silent_p.A582A|NCAM1_ENST00000533760.1_Silent_p.A455A|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	583	Fibronectin type-III 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		CAACGTACGCCGTAAGGCTGG	0.552000													6	11					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616180	248616180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248616180C>T	ENST00000342927.3	+	1	104	c.82C>T	c.(82-84)Ctc>Ttc	p.L28F		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCCCGGGCTTCTCTTTGCAAT	0.527000													36	275					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9100181	9100181	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9100181G>A	ENST00000377424.4	-	6	818	c.639C>T	c.(637-639)ttC>ttT	p.F213F	SLC2A5_ENST00000535586.1_Silent_p.F98F|SLC2A5_ENST00000536305.1_Silent_p.F154F|SLC2A5_ENST00000377414.3_3'UTR	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	213					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGCTCTCGGGGAAGAAGGGCA	0.682000													3	8					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46267784	46267784	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:46267784C>T	ENST00000372004.3	+	14	2761	c.2545C>T	c.(2545-2547)Cgt>Tgt	p.R849C	NCOA3_ENST00000341724.6_Intron|NCOA3_ENST00000371998.3_Missense_Mutation_p.R849C|NCOA3_ENST00000371997.3_Missense_Mutation_p.R859C	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	849					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GCAGTCTATTCGTCCTCCATA	0.373000													53	103					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73056942	73056942	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:73056942T>C	ENST00000261180.4	+	19	3138	c.3042T>C	c.(3040-3042)ctT>ctC	p.L1014L		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1014					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						AAGACGAGCTTTTCCAATGGT	0.393000													16	31					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57437680	57437680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57437680C>T	ENST00000442789.2	-	11	1139	c.852G>A	c.(850-852)caG>caA	p.Q284Q	MYO1A_ENST00000300119.3_Silent_p.Q284Q|MYO1A_ENST00000544473.1_Silent_p.Q122Q	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	284	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TCCCACTGGCCTGGAACTCAT	0.552000													15	36					0	0	1	0	0
KCNC4	3749	broad.mit.edu	37	1	110765834	110765834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110765834C>T	ENST00000369787.3	+	2	954	c.927C>T	c.(925-927)ttC>ttT	p.F309F	KCNC4_ENST00000438661.2_Silent_p.F309F|KCNC4_ENST00000413138.3_Silent_p.F309F|KCNC4_ENST00000412512.2_Intron	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	309					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGCTGGACTTCGTCAAGAACC	0.607000													23	76					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68919784	68919784	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68919784C>T	ENST00000356291.2	-	10	1219	c.1158_splice	c.e10-1	p.G387_splice	RP11-453E17.1_ENST00000500538.2_RNA	NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	387	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						ACCAGAATCTCCCTGAAATAA	0.358000													20	77					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133044138	133044138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133044138C>T	ENST00000262283.5	-	16	1756	c.1657G>A	c.(1657-1659)Gac>Aac	p.D553N	OC90_ENST00000443356.2_Missense_Mutation_p.D357N|OC90_ENST00000254627.3_Missense_Mutation_p.D341N|OC90_ENST00000603859.1_Missense_Mutation_p.D341N			Q02509	OC90_HUMAN	otoconin 90	357					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CTGTCTAGGTCATCCCTTGGC	0.557000													9	19					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100594382	100594382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100594382C>T	ENST00000471714.1	-	8	917	c.808G>A	c.(808-810)Gaa>Aaa	p.E270K	ABI3BP_ENST00000495063.1_Missense_Mutation_p.E270K|ABI3BP_ENST00000284322.5_Missense_Mutation_p.E270K			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	270						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GGAGCTTTTTCTGGGGATTTA	0.438000													19	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071513	9071513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9071513G>A	ENST00000397910.4	-	3	16136	c.15933C>T	c.(15931-15933)acC>acT	p.T5311T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5313	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCATGAGAGTGGTCACCTCTG	0.532000													14	71					0	0	1	0	0
EPO	2056	broad.mit.edu	37	7	100320391	100320391	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100320391C>A	ENST00000252723.2	+	4	532	c.351C>A	c.(349-351)ccC>ccA	p.P117P		NM_000799.2	NP_000790.2	P01588	EPO_HUMAN	erythropoietin	117					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)|endometrium(2)|lung(7)|prostate(1)	12	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CGTGGGAGCCCCTGCAGCTGC	0.652000													19	39					5.26018e-13	5.28629e-13	1	1	0
MTAP	4507	broad.mit.edu	37	9	21859377	21859377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21859377C>T	ENST00000380172.4	+	7	972	c.766C>T	c.(766-768)Cct>Tct	p.P256S	MTAP_ENST00000460874.2_Missense_Mutation_p.P273S|RP11-145E5.5_ENST00000404796.2_Intron|MTAP_ENST00000580900.1_Missense_Mutation_p.P256S|RP11-70L8.4_ENST00000581788.1_RNA	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	256					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	CACTACCATACCTCAGATAGG	0.458000													5	47					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32341039	32341039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32341039C>T	ENST00000375200.1	+	5	916	c.551C>T	c.(550-552)cCt>cTt	p.P184L	ZNF341_ENST00000342427.2_Missense_Mutation_p.P184L			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	184	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						cctcctccacctcctccacca	0.612000													31	57					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25664416	25664416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25664416G>A	ENST00000382051.3	+	3	252	c.202G>A	c.(202-204)Gac>Aac	p.D68N	SLC34A2_ENST00000503434.1_Missense_Mutation_p.D67N|SLC34A2_ENST00000504570.1_Missense_Mutation_p.D67N	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	68					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TGAGGTGGATGACCCCTGGAA	0.522000			T	ROS1	NSCLC								31	79					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64084892	64084892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64084892G>A	ENST00000295902.6	-	8	2955	c.2370C>T	c.(2368-2370)ttC>ttT	p.F790F	RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2_ENST00000564377.1_Silent_p.F846F	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	790						cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GTTCTCCTAGGAAATAGCCCT	0.567000													22	64					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94749806	94749806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94749806G>A	ENST00000283357.5	+	4	495	c.449G>A	c.(448-450)cGa>cAa	p.R150Q		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	150			R -> G (in dbSNP:rs10042271).							central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		CATGGCTTTCGAAAAGAGGAA	0.493000													41	81					0	0	1	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998909	8998909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8998909G>A	ENST00000310455.3	-	2	403	c.253C>T	c.(253-255)Ccg>Tcg	p.P85S	PPP1R3B_ENST00000519699.1_Missense_Mutation_p.P85S	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	85					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		ATATCTAGCGGGTCATCGAAT	0.532000													10	124					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38877410	38877410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38877410C>T	ENST00000359357.3	+	63	9233	c.8979C>T	c.(8977-8979)ttC>ttT	p.F2993F	DNAH8_ENST00000449981.2_Silent_p.F3210F|DNAH8_ENST00000441566.1_Silent_p.F2957F					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CCTCCTACTTCCTTTCAGACT	0.448000													28	81					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183226214	183226214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183226214G>A	ENST00000341319.3	-	3	577	c.542C>T	c.(541-543)gCt>gTt	p.A181V		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	181	BACK.									breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTGTGTGTCAGCCAGCCTCAG	0.488000													31	85					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102269264	102269264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102269264G>A	ENST00000370345.3	-	4	305	c.208C>T	c.(208-210)Cac>Tac	p.H70Y	SEC31B_ENST00000451524.1_Missense_Mutation_p.H70Y|SEC31B_ENST00000535773.1_Intron|NDUFB8_ENST00000531258.1_Intron|NDUFB8_ENST00000557395.1_Intron|SEC31B_ENST00000370329.5_Missense_Mutation_p.H70Y	NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	70					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		ACCAGCTTGTGAAACCTATAA	0.502000											OREG0020441	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	15					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55873040	55873040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55873040G>A	ENST00000388975.3	-	9	1146	c.1030C>T	c.(1030-1032)Caa>Taa	p.Q344*		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	344					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTCTGACATTGATCATAGAAC	0.348000													12	28					0	0	1	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45695524	45695524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45695524C>T	ENST00000305560.6	+	1	996	c.897C>T	c.(895-897)ctC>ctT	p.L299L	SPATA5L1_ENST00000559860.1_Silent_p.L299L	NM_024063.2	NP_076968.2	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	299						cytoplasm	ATP binding|nucleoside-triphosphatase activity			kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GACCCAGCCTCCTCTTCCTGG	0.726000													5	13					0	0	1	0	0
C1orf127	148345	broad.mit.edu	37	1	11008269	11008269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11008269C>T	ENST00000377004.4	-	12	1922	c.1923G>A	c.(1921-1923)atG>atA	p.M641I	C1orf127_ENST00000377008.4_Missense_Mutation_p.M474I	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	492										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		ATGAAAGGTCCATGTGCCCCC	0.647000													8	92					0	0	1	0	0
NAT2	10	broad.mit.edu	37	8	18258341	18258341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18258341G>A	ENST00000286479.3	+	2	935	c.828G>A	c.(826-828)ggG>ggA	p.G276G	NAT2_ENST00000520116.1_Silent_p.G146G	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	276					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		TTTCCTTGGGGAGAAATCTCG	0.358000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				17	62					0	0	1	0	0
BCHE	590	broad.mit.edu	37	3	165503968	165503968	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:165503968C>T	ENST00000264381.3	-	3	1815	c.1649G>A	c.(1648-1650)tGg>tAg	p.W550*	BCHE_ENST00000540653.1_Nonsense_Mutation_p.W12*	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	550					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAATGATGTCCAGAATCGACA	0.353000													10	66					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207751211	207751211	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207751211G>A	ENST00000367049.4	+	29	4599	c.4599G>A	c.(4597-4599)gaG>gaA	p.E1533E	CR1_ENST00000367052.1_Silent_p.E1083E|CR1_ENST00000367051.1_Silent_p.E1083E|CR1_ENST00000400960.2_Silent_p.E1083E|RP11-78B10.2_ENST00000596003.1_RNA|RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367053.1_Silent_p.E1083E	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1083	Sushi 24.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CCAACAGAGAGAATTTTCACT	0.473000													21	102					0	0	1	0	0
DEGS2	123099	broad.mit.edu	37	14	100615443	100615443	+	Silent	SNP	G	G	A	rs145891510		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100615443G>A	ENST00000305631.5	-	2	1262	c.687C>T	c.(685-687)ttC>ttT	p.F229F	DEGS2_ENST00000557117.1_5'UTR|DEGS2_ENST00000553834.1_Intron	NM_206918.2	NP_996801.2	Q6QHC5	DEGS2_HUMAN	delta(4)-desaturase, sphingolipid 2	229					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity	p.F229F(2)		breast(1)|lung(6)|skin(1)	8		Melanoma(154;0.212)				GCTCGGCCACGAAGTGGCCCG	0.622000													37	90					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48698262	48698262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48698262G>A	ENST00000544264.1	-	1	2086	c.1806C>T	c.(1804-1806)atC>atT	p.I602I	CELSR3_ENST00000164024.4_Silent_p.I602I			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	602	Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCACCACCTGGATCTCGCCAG	0.607000													8	23					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179614317	179614317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179614317G>A	ENST00000360870.5	-	46	13032	c.12810C>T	c.(12808-12810)tcC>tcT	p.S4270S	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	416							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGATCTCTGGAATATTTTC	0.383000													32	62					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147120535	147120535	+	Missense_Mutation	SNP	C	C	T	rs148365070	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:147120535C>T	ENST00000383075.3	-	2	562	c.50G>A	c.(49-51)cGa>cAa	p.R17Q	ZIC4_ENST00000484399.1_Missense_Mutation_p.R17Q|ZIC4_ENST00000473123.1_Missense_Mutation_p.R17Q|ZIC4_ENST00000525172.2_Missense_Mutation_p.R67Q|ZIC4_ENST00000425731.3_Missense_Mutation_p.R55Q|ZIC4_ENST00000491672.1_Missense_Mutation_p.R17Q	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	17						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						AAGAGTGTTTCGGTAAAGCCG	0.353000													43	147					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54849490	54849490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54849490G>A	ENST00000291759.4	-	4	428	c.372C>T	c.(370-372)acC>acT	p.T124T		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	124	Ig-like C2-type 2.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GTGCGGACAGGGTGGGTCTGC	0.572000													13	46					0	0	1	0	0
TBC1D21	161514	broad.mit.edu	37	15	74177154	74177154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74177154C>T	ENST00000300504.2	+	5	483	c.400C>T	c.(400-402)Ccc>Tcc	p.P134S	TBC1D21_ENST00000535547.2_Missense_Mutation_p.P98S|TBC1D21_ENST00000562056.1_Intron	NM_153356.1	NP_699187.1	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	134	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	17						TGACAAAGATCCCCTGGGCAA	0.522000													16	40					0	0	1	0	0
INPP5B	3633	broad.mit.edu	37	1	38355359	38355359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38355359G>A	ENST00000373023.2	-	9	1000	c.907C>T	c.(907-909)Cgc>Tgc	p.R303C	INPP5B_ENST00000373024.3_Missense_Mutation_p.R223C|INPP5B_ENST00000373027.1_Missense_Mutation_p.R59C|INPP5B_ENST00000373026.1_Missense_Mutation_p.R303C	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	303					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GTGGAGGAGCGAACCATGTCA	0.388000													44	140					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101060585	101060585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:101060585G>A	ENST00000394095.2	-	15	2198	c.2145C>T	c.(2143-2145)ttC>ttT	p.F715F	SENP7_ENST00000358203.3_Silent_p.F551F|SENP7_ENST00000314261.7_Silent_p.F649F|SENP7_ENST00000348610.3_Silent_p.F682F|SENP7_ENST00000394091.1_Silent_p.F551F|SENP7_ENST00000394094.2_Silent_p.F650F	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7	715					proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GCTTCTGCAGGAAGGTGTAAG	0.438000													18	48					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36642158	36642158	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36642158G>A	ENST00000373448.2	-	3	299	c.61C>T	c.(61-63)Ctc>Ttc	p.L21F	TTI1_ENST00000373447.3_Missense_Mutation_p.L21F|TTI1_ENST00000449821.1_Missense_Mutation_p.L21F|TTI1_ENST00000487362.1_5'UTR	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	21							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						GTCTTTGTGAGCTGAACACAG	0.507000													24	161					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72945959	72945959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:72945959C>T	ENST00000262209.4	-	23	2995	c.2788G>A	c.(2788-2790)Gaa>Aaa	p.E930K	RP11-383H13.1_ENST00000524152.1_Intron|RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000457356.4_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	930						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TGTGCCAATTCATTTCTCAGA	0.378000													10	70					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33840370	33840370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33840370C>T	ENST00000389232.4	+	9	850	c.780C>T	c.(778-780)gcC>gcT	p.A260A	RYR3_ENST00000415757.3_Silent_p.A260A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	260	MIR 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGACTCGAGCCAGGTCTCTTT	0.512000													4	24					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	625222	625222	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:625222G>A	ENST00000588649.2	-	4	939	c.855C>T	c.(853-855)ttC>ttT	p.F285F		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	285					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTCACCATGAATAACACAT	0.622000													27	77					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122795646	122795646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:122795646G>A	ENST00000227349.2	+	4	1203	c.906G>A	c.(904-906)caG>caA	p.Q302Q	C11orf63_ENST00000531316.1_Silent_p.Q302Q	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	302										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		CGTCTATTCAGAATGCCAAGG	0.408000													18	92					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43325417	43325417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43325417G>A	ENST00000361428.2	-	3	712	c.635C>T	c.(634-636)cCt>cTt	p.P212L	ZNF318_ENST00000318149.3_Missense_Mutation_p.P212L	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	212					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GGGACTGAGAGGCCCTTCCTC	0.478000													35	101					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606170	21606170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:21606170G>A	ENST00000281523.2	-	3	690	c.172C>T	c.(172-174)Ccg>Tcg	p.P58S	ZNF385D-AS1_ENST00000412369.1_RNA|ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	58						nucleus	nucleic acid binding|zinc ion binding	p.P58T(1)		NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						TTCTGAATCGGGTCCATCTGT	0.358000													18	69					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713683	46713683	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46713683G>T	ENST00000318962.4	-	23	2564	c.2481C>A	c.(2479-2481)tcC>tcA	p.S827S	ALS2CL_ENST00000415953.1_Silent_p.S827S|ALS2CL_ENST00000383742.3_Silent_p.S174S	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	827	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CCCTGACCAGGGAGTACCTCT	0.647000													9	34					0.00829132	0.00829502	1	1	0
ZNF597	146434	broad.mit.edu	37	16	3487274	3487274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3487274G>A	ENST00000301744.4	-	4	660	c.425C>T	c.(424-426)tCt>tTt	p.S142F	LA16c-306E5.2_ENST00000575785.1_RNA	NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						AAGAATTTCAGAAAGTGTGTT	0.408000													32	127					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120690526	120690526	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120690526C>T	ENST00000527524.2	+	6	695	c.408C>T	c.(406-408)acC>acT	p.T136T	GRIK4_ENST00000438375.2_Silent_p.T136T			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	136					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GATTCACAACCCTGAACCTCC	0.557000													104	279					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50909687	50909687	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50909687C>T	ENST00000440232.2	+	12	1460	c.1407C>T	c.(1405-1407)ctC>ctT	p.L469L	POLD1_ENST00000595904.1_Silent_p.L469L|POLD1_ENST00000599857.1_Silent_p.L469L	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	469					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		AGTACAAGCTCCGCTCCTACA	0.657000								DNA polymerases (catalytic subunits)					4	4					0	0	1	0	0
VCPIP1	80124	broad.mit.edu	37	8	67578798	67578798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:67578798G>A	ENST00000310421.4	-	1	654	c.396C>T	c.(394-396)ccC>ccT	p.P132P		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	132					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			GAGCTAATATGGGCGACAACA	0.557000													27	65					0	0	1	0	0
WNT7B	7477	broad.mit.edu	37	22	46327170	46327170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46327170C>T	ENST00000339464.4	-	3	752	c.378G>A	c.(376-378)ggG>ggA	p.G126G	WNT7B_ENST00000409496.3_Silent_p.G130G|WNT7B_ENST00000410058.1_Silent_p.G126G|WNT7B_ENST00000410089.1_Silent_p.G110G	NM_058238.2	NP_478679.1	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family, member 7B	126					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	19		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		TGCTCAGGTTCCCTTGGCTGC	0.687000													25	47					0	0	1	0	0
OR1L3	26735	broad.mit.edu	37	9	125437581	125437581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125437581C>T	ENST00000304820.2	+	1	267	c.173C>T	c.(172-174)cCt>cTt	p.P58L		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						CTTCAAAACCCTATGTATTTT	0.413000													44	184					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144944740	144944740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144944740C>T	ENST00000525985.1	-	2	2753	c.2682G>A	c.(2680-2682)gaG>gaA	p.E894E				P58107	EPIPL_HUMAN	epiplakin 1	894						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGATACCGGCCTCCAGGAGCT	0.662000													5	16					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176003124	176003124	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176003124G>A	ENST00000510636.1	+	12	1406	c.1132G>A	c.(1132-1134)Gag>Aag	p.E378K	CDHR2_ENST00000261944.5_Missense_Mutation_p.E378K|CDHR2_ENST00000506348.1_Missense_Mutation_p.E378K	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	378	Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CTACGTGGACGAGCATGCCTC	0.627000													18	66					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71707098	71707098	+	Splice_Site	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71707098G>C	ENST00000356340.3	+	36	2561	c.2025_splice	c.e36+1	p.R675_splice	COL13A1_ENST00000398968.3_Splice_Site_p.R656_splice|COL13A1_ENST00000520133.1_Splice_Site_p.R597_splice|COL13A1_ENST00000398966.3_Splice_Site_p.R653_splice|COL13A1_ENST00000398969.3_Splice_Site_p.R603_splice|COL13A1_ENST00000398974.3_Splice_Site_p.R663_splice|COL13A1_ENST00000398972.3_Splice_Site_p.R661_splice|COL13A1_ENST00000398973.3_Splice_Site_p.R649_splice|COL13A1_ENST00000398971.3_Splice_Site_p.R660_splice|COL13A1_ENST00000520267.1_Splice_Site_p.R603_splice|COL13A1_ENST00000398964.3_Splice_Site_p.R646_splice|COL13A1_ENST00000357811.3_Splice_Site_p.R641_splice|COL13A1_ENST00000354547.3_Splice_Site_p.R653_splice|COL13A1_ENST00000517713.1_Splice_Site_p.R626_splice|COL13A1_ENST00000522165.1_Splice_Site_p.R644_splice|COL13A1_ENST00000398978.3_Splice_Site_p.R675_splice			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	675	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AGGGAAACCGGGTGAGTCTGA	0.507000													10	44					0	0	1	0	0
FTH1P10	2502	broad.mit.edu	37	5	17353944	17353944	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:17353944G>A	ENST00000401830.3	-	0	789					NR_002201.1																						GGTGACCAGGGAAGTCACCCC	0.458000													10	22					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55144597	55144597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55144597G>A	ENST00000257290.5	+	15	2402	c.2071G>A	c.(2071-2073)Gat>Aat	p.D691N	FIP1L1_ENST00000507166.1_Missense_Mutation_p.D451N	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	691	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TAAGAATAGGGATAGCTTCCT	0.463000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			19	79					0	0	1	0	0
WARS	7453	broad.mit.edu	37	14	100813129	100813129	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100813129G>A	ENST00000355338.2	-	7	1398	c.780C>T	c.(778-780)ttC>ttT	p.F260F	RP11-638I2.8_ENST00000557226.1_RNA|WARS_ENST00000392882.2_Silent_p.F260F|WARS_ENST00000358655.4_Silent_p.F219F|WARS_ENST00000344102.5_Silent_p.F219F|WARS_ENST00000556645.1_Silent_p.F219F|WARS_ENST00000557135.1_Silent_p.F260F	NM_173701.1	NP_776049.1	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase	260					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	TCACTTGGTTGAAGGTAACAT	0.488000													14	72					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169780186	169780186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169780186C>T	ENST00000263817.6	-	28	4036	c.3912G>A	c.(3910-3912)atG>atA	p.M1304I		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1304	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTTTTTGGGCCATCAGTTCTT	0.512000													15	39					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702757	27702757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27702757G>A	ENST00000438700.3	-	1	540	c.423C>T	c.(421-423)ttC>ttT	p.F141F		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	141					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GCGCCAGCAGGAAGATCCAGG	0.662000													30	78					0	0	1	0	0
LMF2	91289	broad.mit.edu	37	22	50944496	50944496	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50944496G>A	ENST00000216080.5	-	5	835	c.667C>T	c.(667-669)Cga>Tga	p.R223*	LMF2_ENST00000380796.3_Nonsense_Mutation_p.R248*|LMF2_ENST00000474879.2_Nonsense_Mutation_p.R248*|LMF2_ENST00000505981.1_5'UTR			Q9BU23	LMF2_HUMAN	lipase maturation factor 2	248						endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(1)|kidney(1)|lung(4)|prostate(1)|skin(2)	10		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGCAGGCGTCGAATGGGGGCG	0.647000													5	3					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73544831	73544831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73544831G>A	ENST00000224721.6	+	42	5706	c.5701G>A	c.(5701-5703)Gag>Aag	p.E1901K		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1896	Cadherin 18.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GGGCAACCGCGAGCGGGCCTT	0.592000													8	53					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50283911	50283911	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50283911C>A	ENST00000320634.3	-	8	646	c.552G>T	c.(550-552)ggG>ggT	p.G184G	FAIM2_ENST00000550890.1_Silent_p.G138G	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	184					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						TGGACAGCATCCCAGTGAGGT	0.607000													8	62					3.09899e-07	3.10719e-07	1	1	0
DOCK9	23348	broad.mit.edu	37	13	99446979	99446979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:99446979C>T	ENST00000339416.2	-	54	6237	c.6183G>A	c.(6181-6183)acG>acA	p.T2061T	DOCK9_ENST00000376460.1_3'UTR			Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	0					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTAAGACGCTCGTCTTCTCCT	0.512000													12	35					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43412005	43412005	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43412005C>T	ENST00000187910.2	-	4	773	c.706_splice	c.e4-1	p.P236_splice	PSG6_ENST00000292125.2_Splice_Site_p.P236_splice|PSG6_ENST00000402603.4_Intron	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				TGGGCAGCTTCGCTGTGTGGA	0.493000													77	182					0	0	1	0	0
ISM1	140862	broad.mit.edu	37	20	13279769	13279769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:13279769G>A	ENST00000262487.3	+	6	1064	c.1058G>A	c.(1057-1059)gGg>gAg	p.G353E	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	353	AMOP.					extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						GACGCCAGCGGGCCCAAGGAG	0.652000													4	27					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75978949	75978949	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75978949G>A	ENST00000274364.6	+	29	3967	c.3670G>A	c.(3670-3672)Gaa>Aaa	p.E1224K	IQGAP2_ENST00000396234.3_Missense_Mutation_p.E720K|IQGAP2_ENST00000502745.1_Missense_Mutation_p.E720K|IQGAP2_ENST00000379730.3_Missense_Mutation_p.E726K	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1224					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GCTCCTGTTGGAACACCAGGA	0.398000													27	70					0	0	1	0	0
HAS2	3037	broad.mit.edu	37	8	122641360	122641360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:122641360G>A	ENST00000303924.4	-	2	758	c.221C>T	c.(220-222)tCc>tTc	p.S74F		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	74						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GGTTTCTAGGGATTTTTTCAT	0.398000													79	246					0	0	1	0	0
LANCL2	55915	broad.mit.edu	37	7	55467736	55467736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55467736C>T	ENST00000254770.2	+	4	1195	c.617C>T	c.(616-618)gCc>gTc	p.A206V	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	206					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TATCTGTATGCCTTACTGTAC	0.473000													33	114					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291034	33291034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:33291034C>T	ENST00000280979.4	+	13	4185	c.4015C>T	c.(4015-4017)Ctt>Ttt	p.L1339F	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1339					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TTTGCCAGATCTTCTAGGTGG	0.433000													13	41					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783815	54783815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54783815C>T	ENST00000391748.1	-	4	313	c.186G>A	c.(184-186)agG>agA	p.R62R	LILRB2_ENST00000434421.1_5'UTR|LILRB2_ENST00000391746.1_Silent_p.R62R|LILRB2_ENST00000314446.5_Silent_p.R62R|LILRB2_ENST00000391749.4_Silent_p.R62R|LILRB2_ENST00000471216.1_5'UTR	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	62	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ATTTTTTCTCCCTATATAGAC	0.552000													30	183					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123821032	123821032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123821032G>A	ENST00000420886.2	-	5	657	c.658C>T	c.(658-660)Cct>Tct	p.P220S	SBNO1_ENST00000602750.1_Missense_Mutation_p.P219S|SBNO1_ENST00000602398.1_Missense_Mutation_p.P220S|SBNO1_ENST00000267176.4_Missense_Mutation_p.P219S	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	220							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		tttACAACAGGAACCTTCTGC	0.418000													11	29					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234862561	234862561	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234862561C>T	ENST00000324695.4	+	10	1181	c.1140_splice	c.e10-1	p.L381_splice	AC005538.5_ENST00000455991.1_RNA|TRPM8_ENST00000433712.2_Splice_Site_p.L69_splice	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	381						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	ATTTCGCCAGCTCAAAGAAAT	0.373000													12	29					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54656240	54656240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54656240C>T	ENST00000406403.1	+	14	3384	c.1781C>T	c.(1780-1782)cCg>cTg	p.P594L	CNOT3_ENST00000496327.1_3'UTR|CNOT3_ENST00000221232.5_Missense_Mutation_p.P594L|CNOT3_ENST00000358389.3_Missense_Mutation_p.P413L			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	594	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GTGAACATACCGCTGTCGCTG	0.652000													16	94					0	0	1	0	0
CRH	1392	broad.mit.edu	37	8	67089149	67089149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:67089149C>T	ENST00000276571.3	-	2	1010	c.564G>A	c.(562-564)agG>agA	p.R188R		NM_000756.2	NP_000747.1	P06850	CRF_HUMAN	corticotropin releasing hormone	188					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity			breast(1)|endometrium(1)|lung(2)|urinary_tract(1)	5		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	CCATGAGTTTCCTGTTGCTGT	0.453000											OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	48					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	114196635	114196635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114196635C>T	ENST00000369615.1	+	15	2686	c.2624C>T	c.(2623-2625)cCa>cTa	p.P875L	MAGI3_ENST00000369611.4_Missense_Mutation_p.P875L|MAGI3_ENST00000307546.9_Missense_Mutation_p.P875L|MAGI3_ENST00000369617.4_Missense_Mutation_p.P900L	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	900					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAACCACCTCCAGGAGGTAAG	0.448000													59	223					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183211938	183211938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183211938C>T	ENST00000341319.3	-	5	1314	c.1279G>A	c.(1279-1281)Gga>Aga	p.G427R		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	427								p.G427*(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			TCAAAGCCTCCGATCACATAG	0.453000													39	139					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67430791	67430791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67430791G>A	ENST00000349015.3	-	10	1491	c.1053C>T	c.(1051-1053)ccC>ccT	p.P351P	ALDH3B2_ENST00000530069.1_Silent_p.P351P	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	351					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	CCAGGCCGGAGGGGGCGAGCA	0.617000													20	41					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33540299	33540299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33540299G>A	ENST00000404816.2	+	24	4046	c.3693G>A	c.(3691-3693)caG>caA	p.Q1231Q	LTBP1_ENST00000402934.1_Silent_p.Q852Q|LTBP1_ENST00000354476.3_Silent_p.Q1232Q|LTBP1_ENST00000404525.1_Silent_p.Q852Q|LTBP1_ENST00000407925.1_Silent_p.Q905Q|LTBP1_ENST00000272273.5_Silent_p.Q171Q|LTBP1_ENST00000390003.4_Silent_p.Q906Q|LTBP1_ENST00000418533.2_Silent_p.Q905Q			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1231	EGF-like 12; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCTGCCAGCAGGGTTTCTCAA	0.428000													43	62					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21355829	21355829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21355829C>T	ENST00000313654.9	+	10	1588	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F	LAMA3_ENST00000399516.3_Silent_p.F449F	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	449	Domain V.|Laminin EGF-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCCAAATTTCCACGGAGACA	0.493000													27	79					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210857019	210857019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210857019C>T	ENST00000367007.4	-	11	2662	c.2493G>A	c.(2491-2493)tcG>tcA	p.S831S	KCNH1_ENST00000271751.4_Silent_p.S858S	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	858					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GTGTCTCCATCGACTCAGCCT	0.592000													36	109					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43984301	43984301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43984301G>A	ENST00000282406.4	+	26	3949	c.3839G>A	c.(3838-3840)gGg>gAg	p.G1280E		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1280	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ACTCCAGCAGGGCATGTTACC	0.343000													36	89					0	0	1	0	0
OR2V2	285659	broad.mit.edu	37	5	180582494	180582494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180582494C>T	ENST00000328275.1	+	1	552	c.552C>T	c.(550-552)tcC>tcT	p.S184S		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGATGCTATCCTTGTTGAAGC	0.463000													54	231					0	0	1	0	0
C10orf53	282966	broad.mit.edu	37	10	50902647	50902647	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50902647G>A	ENST00000374111.3	+	3	293	c.281G>A	c.(280-282)tGa>tAa	p.*94*	C10orf53_ENST00000374112.3_Intron|C10orf53_ENST00000374113.3_3'UTR|C10orf53_ENST00000535836.1_Intron	NM_001042427.1	NP_001035892.1	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53	0										endometrium(1)|lung(6)	7		all_neural(218;0.107)				AATGCCTACTGATCTCCTCAT	0.512000													18	47					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130736	45130736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45130736G>A	ENST00000457685.2	-	6	2451	c.1128C>T	c.(1126-1128)ttC>ttT	p.F376F	ZNF334_ENST00000593880.1_Silent_p.F437F|ZNF334_ENST00000347606.4_Silent_p.F414F			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				ATTGACAAAAGAAGGTTTTCT	0.423000													18	168					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716446	142716446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142716446C>T	ENST00000381779.4	-	2	2704	c.2479G>A	c.(2479-2481)Gtc>Atc	p.V827I	SLITRK4_ENST00000356928.1_Missense_Mutation_p.V827I|SLITRK4_ENST00000338017.4_Missense_Mutation_p.V827I	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	827						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAAGGACCTGTAGGTAG	0.403000													36	24					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128680491	128680491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128680491G>A	ENST00000344954.6	+	9	1256	c.868G>A	c.(868-870)Gag>Aag	p.E290K	FLI1_ENST00000429175.2_Missense_Mutation_p.E323K|FLI1_ENST00000534087.1_Missense_Mutation_p.E290K|FLI1_ENST00000281428.8_Missense_Mutation_p.E257K|FLI1_ENST00000525560.1_Missense_Mutation_p.E130K			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	323					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GCGCTGGGGCGAGCGGAAAAG	0.552000			T	EWSR1	Ewing sarcoma								12	28					0	0	1	0	0
FOXD4	2298	broad.mit.edu	37	9	116866	116866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116866C>T	ENST00000382500.2	-	1	1551	c.1254G>A	c.(1252-1254)ggG>ggA	p.G418G		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	418					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGGTGAGGTCCCCTCTCCGC	0.697000													7	46					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98819884	98819884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98819884G>A	ENST00000266058.4	-	10	1218	c.973C>T	c.(973-975)Cct>Tct	p.P325S	SLIT1_ENST00000371041.3_Missense_Mutation_p.P325S|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Missense_Mutation_p.P325S	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	325					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GCTCCAGGAGGGATGGACTTG	0.622000													30	75					0	0	1	0	0
SND1	27044	broad.mit.edu	37	7	127343298	127343298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127343298C>T	ENST00000354725.3	+	7	955	c.761C>T	c.(760-762)tCg>tTg	p.S254L		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	254	TNase-like 2.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						TTCACTGAGTCGCGACTGCTT	0.493000													37	75					0	0	1	0	0
KRTAP19-8	728299	broad.mit.edu	37	21	32410599	32410599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32410599C>T	ENST00000382822.2	-	1	196	c.164G>A	c.(163-165)gGa>gAa	p.G55E		NM_001099219.1	NP_001092689.1	Q3LI54	KR198_HUMAN	keratin associated protein 19-8	55						intermediate filament				endometrium(2)|upper_aerodigestive_tract(1)	3						TCCATATCCTCCGTAGTATAA	0.478000													48	151					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118764585	118764585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118764585G>A	ENST00000292174.4	+	2	508	c.332G>A	c.(331-333)gGc>gAc	p.G111D	BCL9L_ENST00000334801.3_3'UTR	NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	111					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GTGGCCGAGGGCTCTGTGGGC	0.627000													29	61					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50847230	50847230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:50847230C>T	ENST00000404971.1	-	9	2709	c.1370G>A	c.(1369-1371)gGa>gAa	p.G457E	NRXN1_ENST00000402717.3_Missense_Mutation_p.G409E|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401669.2_Missense_Mutation_p.G417E|NRXN1_ENST00000406859.3_Missense_Mutation_p.G417E|NRXN1_ENST00000405472.3_Missense_Mutation_p.G409E|NRXN1_ENST00000406316.2_Missense_Mutation_p.G417E	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	417	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGGACTGCCTCCAACATAGAA	0.463000													11	24					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724262	38724262	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:38724262C>T	ENST00000342213.2	-	1	1312	c.966G>A	c.(964-966)agG>agA	p.R322R		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	322						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCTCGTCGACCCTGATTGGCC	0.607000													44	119					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174868913	174868913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:174868913G>A	ENST00000393752.2	-	2	2182	c.1190C>T	c.(1189-1191)tCc>tTc	p.S397F		NM_000794.3	NP_000785.1	P21728	DRD1_HUMAN	dopamine receptor D1	397					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	GTCCTCAGAGGAGCCCACAGC	0.542000													6	74					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125282013	125282013	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125282013C>T	ENST00000340750.1	+	1	594	c.594C>T	c.(592-594)gtC>gtT	p.V198V		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						ATGAGCTGGTCATTTTCACAG	0.473000													30	57					0	0	1	0	0
ASGR2	433	broad.mit.edu	37	17	7012127	7012127	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7012127G>A	ENST00000380952.2	-	3	469	c.205C>T	c.(205-207)Ctg>Ttg	p.L69L	ASGR2_ENST00000355035.5_Silent_p.L69L|ASGR2_ENST00000446679.2_Silent_p.L50L|ASGR2_ENST00000254850.7_Silent_p.L50L	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172.1|NP_001188281.1|NP_550434.1	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	69					cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	ACCAGCAGCAGGATGTTGAAG	0.632000													21	19					0	0	1	0	0
SCYL2	55681	broad.mit.edu	37	12	100708387	100708387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100708387C>T	ENST00000360820.2	+	8	1527	c.1090C>T	c.(1090-1092)Ccc>Tcc	p.P364S		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	364					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						ACCAAAACTGCCCAAGGTTTG	0.303000													9	59					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166964517	166964517	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:166964517G>A	ENST00000061240.2	+	12	2117	c.1470G>A	c.(1468-1470)tgG>tgA	p.W490*	TLL1_ENST00000507499.1_Nonsense_Mutation_p.W490*	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	490	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AATGTGTGTGGAAAATAACAG	0.433000													61	152					0	0	1	0	0
KRTAP6-2	337967	broad.mit.edu	37	21	31971122	31971122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31971122G>A	ENST00000334897.3	-	1	97	c.72C>T	c.(70-72)ggC>ggT	p.G24G		NM_181604.1	NP_853635.1	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	24						intermediate filament				endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11						CATAGCCATAGCCTAGGCCTT	0.572000													32	70					0	0	1	0	0
SPRED2	200734	broad.mit.edu	37	2	65541092	65541092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:65541092G>A	ENST00000356388.4	-	6	989	c.800C>T	c.(799-801)cCc>cTc	p.P267L	SPRED2_ENST00000443619.2_Missense_Mutation_p.P264L	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	267					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						GTCCACGTAGGGGTAGTTGTA	0.682000													34	84					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141952311	141952311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141952311C>T	ENST00000552471.1	-	4	876	c.557G>A	c.(556-558)gGa>gAa	p.G186E	PRSS58_ENST00000547058.2_Missense_Mutation_p.G186E			Q8IYP2	PRS58_HUMAN	protease, serine, 58	186	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						CTGCCTCCTTCCTGGCACAAT	0.423000													58	119					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590485	156590485	+	Missense_Mutation	SNP	C	C	T	rs148999608		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156590485C>T	ENST00000302938.4	-	2	886	c.791G>A	c.(790-792)aGg>aAg	p.R264K		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	264	Ala-rich.					nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACCTGCTGTCCTTGCTGCTCC	0.587000													42	89					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145114840	145114840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145114840G>A	ENST00000426825.1	-	2	177	c.96C>T	c.(94-96)gtC>gtT	p.V32V	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	32							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GCAGTTTTAAGACCCGCACGT	0.667000													15	50					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940784	22940784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22940784G>A	ENST00000397104.3	-	5	1653	c.1654C>T	c.(1654-1656)Cat>Tat	p.H552Y	ZNF99_ENST00000596209.1_Missense_Mutation_p.H643Y					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTCCAGTATGAATTATCTCA	0.363000													21	68					0	0	1	0	0
USP26	83844	broad.mit.edu	37	X	132160463	132160463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:132160463C>T	ENST00000511190.1	-	6	2255	c.1786G>A	c.(1786-1788)Gat>Aat	p.D596N	USP26_ENST00000406273.1_Missense_Mutation_p.D596N|USP26_ENST00000370832.1_Missense_Mutation_p.D596N	NM_031907.1	NP_114113.1	Q9BXU7	UBP26_HUMAN	ubiquitin specific peptidase 26	596					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					GCCAGGATATCTTTGGATTCC	0.398000													31	24					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114268724	114268724	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:114268724C>T	ENST00000393500.3	+	9	932	c.112C>T	c.(112-114)Ctg>Ttg	p.L38L	FOXP2_ENST00000393498.2_Silent_p.L130L|FOXP2_ENST00000393491.3_Silent_p.L38L|FOXP2_ENST00000403559.4_Silent_p.L130L|FOXP2_ENST00000360232.4_Silent_p.L130L|FOXP2_ENST00000408937.3_Silent_p.L155L|FOXP2_ENST00000393494.2_Silent_p.L130L|FOXP2_ENST00000393489.3_Silent_p.L38L|FOXP2_ENST00000350908.4_Silent_p.L130L|FOXP2_ENST00000390668.3_Silent_p.L154L|FOXP2_ENST00000378237.3_Silent_p.L130L|FOXP2_ENST00000459666.1_3'UTR			O15409	FOXP2_HUMAN	forkhead box P2	130					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						GGCTGTCATGCTGCAGCAGGT	0.488000													53	110					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35507460	35507460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35507460C>T	ENST00000217320.3	+	3	250	c.206C>T	c.(205-207)cCa>cTa	p.P69L	TLDC2_ENST00000602922.1_Missense_Mutation_p.P69L	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		TTTCACTTCCCACCAAGAGTC	0.622000													61	177					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104592419	104592419	+	Missense_Mutation	SNP	C	C	T	rs142037395	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104592419C>T	ENST00000369887.3	-	6	1159	c.988G>A	c.(988-990)Gag>Aag	p.E330K		NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	330			Missing (in AH5; complete loss of both 17alpha-hydroxylase and 17,20-lyase activities).		androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	TCAATCTCCTCGTAGAGCTTC	0.532000													33	76					0	0	1	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122958467	122958467	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122958467G>A	ENST00000543897.1	-	12	3342	c.987C>T	c.(985-987)gtC>gtT	p.V329V	ZCCHC8_ENST00000336229.4_Silent_p.V567V|ZCCHC8_ENST00000538116.1_Silent_p.V178V|ZCCHC8_ENST00000536306.1_Silent_p.V329V			Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	567						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TTCCCTCCGGGACAGGGAGGT	0.507000													97	265					0	0	1	0	0
GCM1	8521	broad.mit.edu	37	6	52993438	52993438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52993438C>T	ENST00000259803.7	-	6	1088	c.877G>A	c.(877-879)Gat>Aat	p.D293N		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	293						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					GCTTGTAGATCGCCATGATCA	0.473000													9	73					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7773905	7773905	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:7773905A>T	ENST00000358415.4	+	13	1759	c.1593A>T	c.(1591-1593)ggA>ggT	p.G531G	ITIH2_ENST00000379587.4_Silent_p.G520G	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	531					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TGGTGGCAGGAAAATTTGACC	0.433000													47	92					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5204841	5204841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5204841C>T	ENST00000334314.3	-	2	312	c.236G>A	c.(235-237)aGa>aAa	p.R79K						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						TATTTCCTCTCTCTTGACGGT	0.423000													50	175					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81167172	81167172	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81167172G>A	ENST00000534142.1	-	0	241				PKD1L2_ENST00000533478.1_RNA|PKD1L2_ENST00000525539.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						GCCTACCCAGGATTTCTCTGA	0.527000													7	37					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321402	52321402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:52321402G>A	ENST00000356297.4	-	17	2882	c.2782C>T	c.(2782-2784)Ccc>Tcc	p.P928S	PXDNL_ENST00000543296.1_Missense_Mutation_p.P928S	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	928					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.P127S(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTTCCGGAGGGAGGCCAAGGA	0.647000													9	15					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76257129	76257129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76257129C>T	ENST00000529032.1	+	19	3562	c.3562C>T	c.(3562-3564)Ccc>Tcc	p.P1188S	C11orf30_ENST00000343878.3_Intron|C11orf30_ENST00000524767.1_Missense_Mutation_p.P1203S|C11orf30_ENST00000524490.1_Missense_Mutation_p.P1090S|C11orf30_ENST00000525038.1_Missense_Mutation_p.P1189S|C11orf30_ENST00000525919.1_Missense_Mutation_p.P1189S|C11orf30_ENST00000334736.3_Missense_Mutation_p.P1188S|C11orf30_ENST00000533248.1_Missense_Mutation_p.P1097S			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1188					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						AGGATCATTACCCTCCACCCA	0.502000													26	67					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57480853	57480853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57480853G>A	ENST00000371236.2	-	12	1410	c.1147C>T	c.(1147-1149)Ccc>Tcc	p.P383S	DAB1_ENST00000371231.1_Missense_Mutation_p.P416S|DAB1_ENST00000439789.2_Missense_Mutation_p.P297S|DAB1_ENST00000371234.4_Missense_Mutation_p.P383S|DAB1_ENST00000420954.2_Missense_Mutation_p.P381S|DAB1_ENST00000414851.2_Missense_Mutation_p.P365S|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	416					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GGGGTGAGGGGACCTTGGAAC	0.592000													27	67					0	0	1	0	0
IDO1	3620	broad.mit.edu	37	8	39785360	39785360	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39785360C>T	ENST00000518237.1	+	10	1507	c.868C>T	c.(868-870)Cag>Tag	p.Q290*	RP11-44K6.3_ENST00000517623.1_RNA|IDO1_ENST00000522495.1_Nonsense_Mutation_p.Q290*	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	290					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	ACATGCTGCTCAGTTCCTCCA	0.483000													3	9					0	0	1	0	0
TBPL2	387332	broad.mit.edu	37	14	55903639	55903639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:55903639G>A	ENST00000247219.5	-	2	318	c.248C>T	c.(247-249)tCg>tTg	p.S83L		NM_199047.2	NP_950248.1	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	83					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding	p.S83L(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8						TTCAGGGTTCGAATTAAATGC	0.448000													28	97					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204943415	204943415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204943415G>A	ENST00000367172.4	+	13	1716	c.1388G>A	c.(1387-1389)cGa>cAa	p.R463Q	NFASC_ENST00000404076.1_Missense_Mutation_p.R457Q|NFASC_ENST00000513543.1_Missense_Mutation_p.R474Q|NFASC_ENST00000367171.4_Missense_Mutation_p.R463Q|NFASC_ENST00000403080.1_Missense_Mutation_p.R463Q|NFASC_ENST00000339876.6_Missense_Mutation_p.R463Q|NFASC_ENST00000539706.1_Missense_Mutation_p.R474Q|NFASC_ENST00000404907.1_Missense_Mutation_p.R474Q|NFASC_ENST00000360049.4_Missense_Mutation_p.R474Q|NFASC_ENST00000367170.4_Missense_Mutation_p.R463Q|NFASC_ENST00000401399.1_Missense_Mutation_p.R463Q|NFASC_ENST00000367169.4_Missense_Mutation_p.R463Q|NFASC_ENST00000338586.6_Missense_Mutation_p.R463Q|NFASC_ENST00000338515.6_Missense_Mutation_p.R463Q			O94856	NFASC_HUMAN	neurofascin	463	Ig-like C2-type 5.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.R474Q(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCCACACTGCGATGGTAAGTT	0.572000													7	19					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87487747	87487747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87487747G>A	ENST00000327946.7	-	10	1483	c.1398C>T	c.(1396-1398)ttC>ttT	p.F466F	GRID1_ENST00000536331.1_Silent_p.F37F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	466						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	CATCTATGGAGAACCCTTTGT	0.493000										Multiple Myeloma(13;0.14)			30	170					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65788286	65788286	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65788286G>A	ENST00000312106.5	-	6	2060	c.1923C>T	c.(1921-1923)gcC>gcT	p.A641A		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	641					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CCCTACCCTGGGCACGGCTGT	0.637000													11	38					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2778188	2778188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2778188G>A	ENST00000399655.1	+	38	4978	c.4713G>A	c.(4711-4713)agG>agA	p.R1571R	CACNA1C_ENST00000399637.1_Silent_p.R1571R|CACNA1C_ENST00000335762.5_Silent_p.R1596R|CACNA1C_ENST00000399603.1_Silent_p.R1571R|CACNA1C_ENST00000399649.1_Silent_p.R1558R|CACNA1C_ENST00000399595.1_Silent_p.R1560R|CACNA1C_ENST00000399606.1_Silent_p.R1591R|CACNA1C_ENST00000399601.1_Silent_p.R1571R|CACNA1C_ENST00000399617.1_Silent_p.R1571R|CACNA1C_ENST00000344100.3_Silent_p.R1593R|CACNA1C_ENST00000399621.1_Silent_p.R1571R|CACNA1C_ENST00000399629.1_Silent_p.R1588R|CACNA1C_ENST00000327702.7_Silent_p.R1571R|CACNA1C_ENST00000406454.3_Silent_p.R1571R|CACNA1C_ENST00000402845.3_Silent_p.R1571R|CACNA1C_ENST00000399597.1_Silent_p.R1571R|CACNA1C_ENST00000347598.4_Silent_p.R1619R|CACNA1C_ENST00000399641.1_Silent_p.R1571R|CACNA1C_ENST00000399638.1_Silent_p.R1599R|CACNA1C_ENST00000399644.1_Silent_p.R1571R|CACNA1C_ENST00000399591.1_Silent_p.R1560R|CACNA1C-AS2_ENST00000545526.1_RNA|CACNA1C_ENST00000399634.1_Silent_p.R1571R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1619					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CGGCCCTGAGGATCAAAACAG	0.572000													40	80					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437486	120437486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:120437486C>T	ENST00000369400.1	-	1	1632	c.1474G>A	c.(1474-1476)Gaa>Aaa	p.E492K		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	492	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CAACGGCCTTCATACTTGCAA	0.488000													26	44					0	0	1	0	0
ZSCAN23	222696	broad.mit.edu	37	6	28403868	28403868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28403868G>A	ENST00000289788.4	-	2	321	c.176C>T	c.(175-177)tCc>tTc	p.S59F	ZSCAN23_ENST00000486481.1_Intron	NM_001012455.1	NP_001012458.1	Q3MJ62	ZSC23_HUMAN	zinc finger and SCAN domain containing 23	59	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|prostate(1)|stomach(2)	4						GGGCCCAGGGGACTCCTGATA	0.552000													18	39					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507766	155507766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155507766C>T	ENST00000302053.3	-	5	893	c.815G>A	c.(814-816)gGa>gAa	p.G272E	FGA_ENST00000403106.3_Missense_Mutation_p.G272E	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	272					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GGTGGAGCCTCCTCGAGTAAT	0.537000													63	121					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179476841	179476841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179476841C>T	ENST00000589042.1	-	267	50521	c.50297G>A	c.(50296-50298)cGa>cAa	p.R16766Q	TTN_ENST00000342992.6_Missense_Mutation_p.R14198Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R7701Q|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R7893Q|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R7826Q|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R15125Q|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15125	Ig-like 101.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R14198P(2)|p.R7701P(1)|p.R7893P(1)|p.R7826P(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCAACATGTCGTTTTGTCAC	0.398000													6	21					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9088430	9088430	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9088430G>A	ENST00000397910.4	-	1	3588	c.3385C>T	c.(3385-3387)Ctg>Ttg	p.L1129L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1129	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTGGAGTCAGAGCTGAGCTT	0.458000													20	55					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914542	51914542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51914542C>T	ENST00000353836.5	-	10	1841	c.1620G>A	c.(1618-1620)aaG>aaA	p.K540K	SIGLEC10_ENST00000441969.3_Silent_p.K482K|SIGLEC10_ENST00000439889.2_Silent_p.K577K|SIGLEC10_ENST00000525998.1_Silent_p.K450K|SIGLEC10_ENST00000436984.2_Silent_p.K492K|SIGLEC10_ENST00000432469.2_Silent_p.K457K|SIGLEC10_ENST00000339313.5_Silent_p.K635K|SIGLEC10_ENST00000356298.5_Silent_p.K635K|SIGLEC10_ENST00000442846.3_Silent_p.K392K	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	635					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		TTTTCTGGTTCTTCTTTGATT	0.532000													51	133					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102904439	102904439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102904439C>T	ENST00000359520.7	+	10	2701	c.2475C>T	c.(2473-2475)tgC>tgT	p.C825C	TECPR2_ENST00000558678.1_Silent_p.C825C	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	825							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						ATATCTGGTGCCTGGACTACA	0.597000											OREG0022547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	146					0	0	1	0	0
TACSTD2	4070	broad.mit.edu	37	1	59042069	59042069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:59042069C>T	ENST00000371225.2	-	1	1097	c.760G>A	c.(760-762)Gag>Aag	p.E254K		NM_002353.2	NP_002344.2	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	254					cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity					all_cancers(7;6.54e-05)					AGCGTGCGCTCCACCTGCAGG	0.642000													8	21					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3632689	3632689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3632689G>A	ENST00000294008.3	-	15	5799	c.5159C>T	c.(5158-5160)tCc>tTc	p.S1720F	RP11-461A8.1_ENST00000573982.1_lincRNA	NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1720	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.|Poly-Ser.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CTCACAGGAGGAAGAACTGAA	0.592000								Direct reversal of damage					4	25					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150267063	150267063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150267063G>A	ENST00000461940.1	+	2	157	c.74G>A	c.(73-75)aGt>aAt	p.S25N	GIMAP4_ENST00000255945.2_Intron|GIMAP4_ENST00000494750.1_Intron			Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	20							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGCATTCAGTGCTCCCCAG	0.592000													10	56					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187042	140187042	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140187042C>T	ENST00000530339.1	+	1	270	c.270C>T	c.(268-270)atC>atT	p.I90I	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.I90I|PCDHA4_ENST00000512229.2_Silent_p.I90I|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGACCGGGAGG	0.622000													40	96					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42128605	42128605	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42128605G>A	ENST00000401548.3	+	11	1369	c.1329G>A	c.(1327-1329)ctG>ctA	p.L443L	MEI1_ENST00000540833.1_Silent_p.L183L|MEI1_ENST00000400107.1_5'UTR|MEI1_ENST00000300398.4_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	443							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CTGCTTTTCTGAGGTGAGAGA	0.542000													16	46					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84366585	84366585	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:84366585C>T	ENST00000428679.2	-	7	1140		c.e7-1		SNAP91_ENST00000520302.1_Splice_Site|SNAP91_ENST00000369694.2_Splice_Site|SNAP91_ENST00000439399.2_Splice_Site|SNAP91_ENST00000520213.1_Splice_Site|SNAP91_ENST00000195649.6_Splice_Site|SNAP91_ENST00000521743.1_Splice_Site|SNAP91_ENST00000437520.1_Splice_Site|SNAP91_ENST00000521485.1_Splice_Site			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa						clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TTGGATGCACCTAGAAAAACA	0.289000													5	9					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171486848	171486848	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171486848C>T	ENST00000367742.3	+	6	887	c.645C>T	c.(643-645)atC>atT	p.I215I	PRRC2C_ENST00000476522.1_3'UTR|PRRC2C_ENST00000426496.2_Silent_p.I213I|PRRC2C_ENST00000338920.4_Silent_p.I213I|PRRC2C_ENST00000392078.3_Silent_p.I215I			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	213							protein C-terminus binding										AAAATGATATCCTCAAAGTGG	0.498000													15	36					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15587019	15587019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15587019G>A	ENST00000292609.4	-	2	591	c.462C>T	c.(460-462)acC>acT	p.T154T	PGLYRP2_ENST00000340880.4_Silent_p.T154T			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	154					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						CATCTGGAAAGGTATCTCCAG	0.587000													17	82					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23814665	23814665	+	Missense_Mutation	SNP	G	G	A	rs149856244		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:23814665G>A	ENST00000264867.2	-	9	1996	c.1877C>T	c.(1876-1878)tCg>tTg	p.S626L	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	626	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding	p.S626L(1)		central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GCTGTAGGGCGATCTTGAACG	0.493000													64	119					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38141867	38141867	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38141867C>T	ENST00000308059.6	+	19	2836	c.2815C>T	c.(2815-2817)Cag>Tag	p.Q939*	DLEC1_ENST00000346219.3_Nonsense_Mutation_p.Q939*|DLEC1_ENST00000452631.2_Nonsense_Mutation_p.Q939*			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	939					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCTGCACTGCCAGCATCTGGA	0.582000													36	85					0	0	1	0	0
CARD10	29775	broad.mit.edu	37	22	37903940	37903940	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37903940G>A	ENST00000403299.1	-	7	1303	c.1087C>T	c.(1087-1089)Ctg>Ttg	p.L363L	CARD10_ENST00000406271.3_Silent_p.L77L|CARD10_ENST00000251973.5_Silent_p.L363L			Q9BWT7	CAR10_HUMAN	caspase recruitment domain family, member 10	363					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					TTGAGCCGCAGGTCTTCCATC	0.627000													23	88					0	0	1	0	0
SH3RF3	344558	broad.mit.edu	37	2	110065788	110065788	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:110065788C>T	ENST00000309415.6	+	8	1991	c.1991C>T	c.(1990-1992)cCg>cTg	p.P664L		NM_001099289.1	NP_001092759.1	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	664							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(5)|ovary(2)	18						TGCCCACGGCCGGCCATCCCC	0.677000													5	17					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59211041	59211041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59211041C>T	ENST00000302030.2	+	1	425	c.400C>T	c.(400-402)Ctc>Ttc	p.L134F		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						CAGCCCCCTTCTCTACCCCAC	0.547000													72	278					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47344548	47344548	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47344548G>A	ENST00000398879.1	-	21	3070	c.2704C>T	c.(2704-2706)Ccc>Tcc	p.P902S	TNS3_ENST00000311160.9_Missense_Mutation_p.P902S|TNS3_ENST00000355730.3_Missense_Mutation_p.P662S			Q68CZ2	TENS3_HUMAN	tensin 3	902						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GGTCCGATGGGGCTCTCTGAC	0.597000													14	38					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155150523	155150523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155150523G>A	ENST00000392451.2	+	6	1038	c.955G>A	c.(955-957)Ggg>Agg	p.G319R	TRIM46_ENST00000545012.1_Missense_Mutation_p.G193R|TRIM46_ENST00000368382.1_Missense_Mutation_p.G296R|TRIM46_ENST00000468878.1_3'UTR|TRIM46_ENST00000368383.3_Missense_Mutation_p.G319R|TRIM46_ENST00000543729.1_Missense_Mutation_p.G326R|TRIM46_ENST00000334634.4_Missense_Mutation_p.G319R|TRIM46_ENST00000368385.4_Missense_Mutation_p.G319R			Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	319						intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCTGGTGCGGGGGCTGGGGGC	0.617000													19	39					0	0	1	0	0
DZIP1L	199221	broad.mit.edu	37	3	137816641	137816641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:137816641G>A	ENST00000327532.2	-	3	912	c.550C>T	c.(550-552)Cac>Tac	p.H184Y	DZIP1L_ENST00000469243.1_Missense_Mutation_p.H184Y	NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	184						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						cgctggatgtggccccggaga	0.577000											OREG0015831	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	17					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105261008	105261008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:105261008G>A	ENST00000507740.1	+	19	3234	c.2998G>A	c.(2998-3000)Gtg>Atg	p.V1000M	RIMS2_ENST00000339750.2_Missense_Mutation_p.V122M|RIMS2_ENST00000406091.3_Missense_Mutation_p.V1186M|RIMS2_ENST00000262231.10_Missense_Mutation_p.V1025M|RIMS2_ENST00000436393.2_Missense_Mutation_p.V1204M	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1248					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGCTCAGCTAGTGGGACGCCA	0.428000										HNSCC(12;0.0054)			21	52					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660736	77660736	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77660736A>T	ENST00000296043.6	+	5	2363	c.1410A>T	c.(1408-1410)gtA>gtT	p.V470V		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	470					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TCTACCCGGTACCTTCCCTGG	0.577000													29	76					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164095	26164095	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26164095C>T	ENST00000335473.7	+	4	462	c.212C>T	c.(211-213)tCc>tTc	p.S71F	MYO18B_ENST00000536101.1_Missense_Mutation_p.S71F|MYO18B_ENST00000407587.2_Missense_Mutation_p.S71F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	71	Ser-rich.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCAGAAATTTCCATCAGCCAA	0.498000													42	139					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450081	158450081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158450081G>A	ENST00000368152.1	+	1	414	c.414G>A	c.(412-414)atG>atA	p.M138I	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M138I(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					TGGGTGTGATGGGTTATGATC	0.483000													92	272					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111164364	111164364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111164364C>T	ENST00000360467.5	+	48	5271	c.4965C>T	c.(4963-4965)ttC>ttT	p.F1655F		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1655	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCACACCATTCATCGAATGCA	0.632000													29	85					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158735998	158735998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158735998C>T	ENST00000335094.2	-	1	494	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					AAGGAAATTTCAACTACTGGC	0.537000													23	54					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48595010	48595010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48595010G>A	ENST00000323776.5	+	4	710	c.548G>A	c.(547-549)gGg>gAg	p.G183E	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.G146E	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	146					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CACATCTTGGGGAGTCTCCAG	0.512000													27	40					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	31010117	31010117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31010117C>T	ENST00000295055.8	-	2	251	c.75G>A	c.(73-75)cgG>cgA	p.R25R	CAPN13_ENST00000534090.2_Silent_p.R25R|CAPN13_ENST00000465960.2_5'UTR	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	25					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					GGCAGTGATCCCGCAAGGTGG	0.522000													9	21					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27803388	27803388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27803388G>A	ENST00000408964.2	+	1	4000	c.3949G>A	c.(3949-3951)Gaa>Aaa	p.E1317K		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1317										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					TCCTTCTAGGGAATTAGCAGC	0.398000													13	64					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49001477	49001477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49001477C>T	ENST00000600059.1	-	11	3076	c.2849G>A	c.(2848-2850)gGg>gAg	p.G950E	LMTK3_ENST00000270238.3_Missense_Mutation_p.G979E					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTCGGGGGACCCCAGGGCCCC	0.642000													34	102					0	0	1	0	0
TRBV20-1	28567	broad.mit.edu	37	7	142334236	142334236	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142334236G>A	ENST00000390394.3	+	0	74																											AGGCCATCACGGAAGATGCTG	0.567000											OREG0018395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	28					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581070	234581070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234581070C>T	ENST00000354728.4	+	1	572	c.490C>T	c.(490-492)Ccc>Tcc	p.P164S	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		TTTCTCCCTCCCCTCCGTGGT	0.433000													69	195					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41452225	41452225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41452225C>T	ENST00000400454.1	-	25	4751	c.4274G>A	c.(4273-4275)gGg>gAg	p.G1425E		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1425	Fibronectin type-III 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGAAAACTCCCCCACTGCTC	0.473000													12	56					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91779837	91779837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91779837G>A	ENST00000389857.6	-	15	2409	c.2323C>T	c.(2323-2325)Ctg>Ttg	p.L775L		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	775					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTGCTCTCCAGGCTCTGCTGC	0.662000													12	21					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67943846	67943846	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:67943846C>T	ENST00000252336.6	+	13	3209	c.2837C>T	c.(2836-2838)cCg>cTg	p.P946L	STARD8_ENST00000374597.3_Missense_Mutation_p.P946L|STARD8_ENST00000374599.3_Missense_Mutation_p.P1026L	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	946	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						TCCCTGGATCCGGAACAACCT	0.607000													24	23					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18725439	18725439	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18725439G>A	ENST00000440756.2	-	4	1481	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F	PSD3_ENST00000327040.8_Missense_Mutation_p.S460F|PSD3_ENST00000523619.1_Missense_Mutation_p.S395F			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	460					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TGTCTCCAGGGACTCTGCACT	0.458000													42	91					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493706	55493706	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55493706C>T	ENST00000543010.1	+	6	783	c.640C>T	c.(640-642)Cct>Tct	p.P214S	NLRP2_ENST00000263437.6_Missense_Mutation_p.P211S|NLRP2_ENST00000537859.1_Missense_Mutation_p.P192S|NLRP2_ENST00000391721.4_Missense_Mutation_p.P190S|NLRP2_ENST00000448584.2_Missense_Mutation_p.P214S|NLRP2_ENST00000339757.7_Missense_Mutation_p.P192S|NLRP2_ENST00000538819.1_Missense_Mutation_p.P190S|NLRP2_ENST00000427260.2_Missense_Mutation_p.P191S	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	214	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GCTGTATGGTCCTGCAGGCCT	0.532000													29	76					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101818648	101818648	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:101818648C>T	ENST00000375001.3	+	35	3722	c.3299C>T	c.(3298-3300)cCc>cTc	p.P1100L		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1100	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				CCACCGGGGCCCCCGGGGCCA	0.627000													13	65					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37282783	37282783	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:37282783G>A	ENST00000373091.3	-	13	1985	c.1969C>T	c.(1969-1971)Ctg>Ttg	p.L657L	GRIK3_ENST00000373093.4_Silent_p.L657L	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	657					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AAGGCAGCCAGGTTGGCCGTG	0.552000													36	57					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2939141	2939141	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2939141G>A	ENST00000378404.2	+	1	1096	c.891G>A	c.(889-891)ggG>ggA	p.G297G		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	297						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		TCCTCTTTGGGGAGATTGTGC	0.607000													35	90					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12203533	12203533	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12203533G>A	ENST00000432424.2	+	0	1031							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AAACCACTACGACTTCCAGGA	0.527000													21	29					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65621371	65621371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65621371G>A	ENST00000327987.4	-	14	2572	c.2321C>T	c.(2320-2322)gCt>gTt	p.A774V		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	774										breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						GGCGCAGGGAGCCGTGGCCTC	0.711000													17	13					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137928454	137928454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:137928454G>A	ENST00000409968.1	+	7	1847	c.1669G>A	c.(1669-1671)Gga>Aga	p.G557R	THSD7B_ENST00000272643.3_Missense_Mutation_p.G557R|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.G526R					thrombospondin, type I, domain containing 7B									p.G526R(1)|p.G557R(1)		NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCCTGATCATGGAAAATGTGG	0.522000													13	31					0	0	1	0	0
SLC35G1	159371	broad.mit.edu	37	10	95660749	95660749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95660749C>T	ENST00000371408.3	+	3	658	c.597C>T	c.(595-597)atC>atT	p.I199I	SLC35G1_ENST00000427197.1_Silent_p.I200I			Q2M3R5	TMM20_HUMAN	solute carrier family 35, member G1	200	DUF6 1.					integral to membrane											TGATCCTTATCGTGAGACCAC	0.448000													22	54					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774549	40774549	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:40774549G>A	ENST00000602553.1	-	5	1020	c.726C>T	c.(724-726)tcC>tcT	p.S242S	ZNF658_ENST00000441795.1_Silent_p.S240S|ZNF658_ENST00000377626.3_Silent_p.S242S			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CATCCTTACAGGACTTTTCTC	0.328000													24	93					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123556375	123556375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:123556375G>A	ENST00000422452.2	-	24	4281	c.4218C>T	c.(4216-4218)atC>atT	p.I1406I	TENM1_ENST00000371130.3_Silent_p.I1399I|STAG2_ENST00000469481.1_3'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GGCGTCCTGCGATGATCCGAA	0.498000													40	40					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41804342	41804342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41804342C>T	ENST00000263800.6	-	4	577	c.481G>A	c.(481-483)Ggg>Agg	p.G161R	LTK_ENST00000355166.5_Missense_Mutation_p.G161R|LTK_ENST00000453182.2_Missense_Mutation_p.G161R|LTK_ENST00000561619.1_Intron	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	161					apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CCCTGCTGCCCCACCAGGATG	0.726000										TSP Lung(18;0.14)			10	29					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107314668	107314668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107314668G>A	ENST00000265715.3	+	5	699	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	159					regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GGCCCCCGACGAACACTTTCT	0.433000									Pendred syndrome				41	110					0	0	1	0	0
PPIL2	23759	broad.mit.edu	37	22	22039149	22039149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22039149C>T	ENST00000406385.1	+	10	721	c.661C>T	c.(661-663)Ctg>Ttg	p.L221L	PPIL2_ENST00000335025.7_Silent_p.L221L|PPIL2_ENST00000492445.2_Silent_p.L221L|PPIL2_ENST00000412327.1_Silent_p.L221L|PPIL2_ENST00000398831.3_Silent_p.L221L|PPIL2_ENST00000456792.2_Silent_p.L200L			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	221					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					GGACGAGATTCTGGCAGCCAC	0.562000													24	39					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105609479	105609479	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105609479G>A	ENST00000331782.3	-	26	3673	c.3270C>T	c.(3268-3270)gcC>gcT	p.A1090A	JAG2_ENST00000347004.2_Silent_p.A1052A	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	1090					auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		GCACGCTGAAGGCACCACACA	0.692000													19	37					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2416007	2416007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2416007G>A	ENST00000449969.1	+	5	846	c.685G>A	c.(685-687)Gac>Aac	p.D229N	PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000288766.5_Intron|PLCH2_ENST00000419816.2_Missense_Mutation_p.D256N|PLCH2_ENST00000378486.3_Missense_Mutation_p.D256N|PLCH2_ENST00000378488.3_Missense_Mutation_p.D256N			O75038	PLCH2_HUMAN	phospholipase C, eta 2	256	EF-hand 2.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CAACCACAAGGACCACCTGGA	0.622000													17	44					0	0	1	0	0
SERGEF	26297	broad.mit.edu	37	11	18026017	18026017	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18026017G>A	ENST00000265965.5	-	4	569	c.418C>T	c.(418-420)Cga>Tga	p.R140*	SERGEF_ENST00000532265.1_Nonsense_Mutation_p.R26*|RP1-59M18.2_ENST00000525523.1_RNA|SERGEF_ENST00000528200.1_Nonsense_Mutation_p.R140*|SERGEF_ENST00000532212.1_5'UTR	NM_012139.2	NP_036271.1	Q9UGK8	SRGEF_HUMAN	secretion regulating guanine nucleotide exchange factor	140					negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(5)|lung(5)	12						ACACATCTTCGAGGTCCATGA	0.418000													9	22					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110477352	110477352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:110477352G>A	ENST00000260283.4	-	10	1181	c.897C>T	c.(895-897)ctC>ctT	p.L299L	ARHGAP20_ENST00000524756.1_Silent_p.L276L|ARHGAP20_ENST00000528829.1_Silent_p.L263L|ARHGAP20_ENST00000357139.3_Silent_p.L273L|ARHGAP20_ENST00000533353.1_Silent_p.L273L|ARHGAP20_ENST00000527598.1_Silent_p.L263L	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	299					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCTCTCGGGGGAGCTGTTCCA	0.537000													96	194					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3084090	3084090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3084090G>A	ENST00000397461.1	+	20	2879	c.2495G>A	c.(2494-2496)cGa>cAa	p.R832Q	CNTN4_ENST00000418658.1_Missense_Mutation_p.R832Q|CNTN4_ENST00000448906.2_Missense_Mutation_p.R504Q|CNTN4_ENST00000358480.3_Missense_Mutation_p.R613Q|CNTN4_ENST00000397459.2_Missense_Mutation_p.R504Q|CNTN4_ENST00000427331.1_Missense_Mutation_p.R832Q|CNTN4-AS1_ENST00000442749.2_RNA	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	832	Fibronectin type-III 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AATAGAGGACGAATACAAGGT	0.463000													19	36					0	0	1	0	0
VPS37D	155382	broad.mit.edu	37	7	73085400	73085400	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73085400C>T	ENST00000324941.4	+	4	584	c.450C>T	c.(448-450)gcC>gcT	p.A150A	VPS37D_ENST00000451519.1_Silent_p.A65A	NM_001077621.1	NP_001071089.1	Q86XT2	VP37D_HUMAN	vacuolar protein sorting 37 homolog D (S. cerevisiae)	150	VPS37 C-terminal.				cellular membrane organization|endosome transport|protein transport	late endosome membrane				central_nervous_system(1)|ovary(1)	2		Lung NSC(55;0.0908)|all_lung(88;0.198)				TCCTGCCTGCCTTCCAGCGTG	0.706000													13	28					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9498830	9498830	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9498830C>T	ENST00000246070.2	+	5	1111	c.619C>T	c.(619-621)Cac>Tac	p.H207Y	LAMP5_ENST00000427562.2_Missense_Mutation_p.H163Y	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	207						integral to membrane											GTCTGCGGTCCACATCCAACC	0.483000													5	78					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121016411	121016411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121016411C>T	ENST00000392793.1	+	12	3962	c.3691C>T	c.(3691-3693)Cgg>Tgg	p.R1231W	TECTA_ENST00000264037.2_Missense_Mutation_p.R1231W|TECTA_ENST00000478058.1_3'UTR			O75443	TECTA_HUMAN	tectorin alpha	1231	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CACAGTCCCTCGGAGCATGCA	0.507000													30	52					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130407850	130407850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130407850C>T	ENST00000370904.1	-	26	4814	c.3904G>A	c.(3904-3906)Gaa>Aaa	p.E1302K	IGSF1_ENST00000370903.3_Missense_Mutation_p.E1316K|IGSF1_ENST00000370910.1_Missense_Mutation_p.E1302K|IGSF1_ENST00000361420.3_Missense_Mutation_p.E1311K			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1311					regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GGTTCTCCTTCTTGGTTACAC	0.463000													89	48					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36253876	36253876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36253876C>T	ENST00000296604.3	-	12	1525	c.1040G>A	c.(1039-1041)gGc>gAc	p.G347D	RANBP3L_ENST00000502994.1_Missense_Mutation_p.G372D	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	347	RanBD1.				intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CCTTAGACTGCCTTGATTGCG	0.393000													29	76					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2411249	2411249	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2411249C>T	ENST00000288766.5	+	3	622	c.213_splice	c.e3+1	p.F71_splice	PLCH2_ENST00000378483.2_Intron|PLCH2_ENST00000419816.2_Silent_p.F116F|PLCH2_ENST00000378486.3_Silent_p.F116F|PLCH2_ENST00000449969.1_Silent_p.F89F|PLCH2_ENST00000378488.3_Silent_p.F116F			O75038	PLCH2_HUMAN	phospholipase C, eta 2	783	Necessary for plasma membrane localization (By similarity).|PH.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		ACGGCAGCTTCGACCCCAACT	0.677000													5	11					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518778	113518778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113518778C>T	ENST00000284601.3	-	4	2437	c.2369G>A	c.(2368-2370)cGa>cAa	p.R790Q		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	790					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TACTGTATCTCGTTGACAAAG	0.398000													19	63					0	0	1	0	0
TRGJP2	6972	broad.mit.edu	37	7	38295943	38295943	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38295943G>A	ENST00000390334.1	-	0	54																											CTTACCAGGCGAAGTTACTAT	0.338000													8	13					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230231657	230231657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230231657C>T	ENST00000341772.4	-	12	2168	c.2034G>A	c.(2032-2034)gaG>gaA	p.E678E		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	678	Interaction with AP1G1 and somatodendritic targeting (By similarity).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGTAGAACTCCTCATAGGCTG	0.582000													22	47					0	0	1	0	0
HMGCL	3155	broad.mit.edu	37	1	24140689	24140689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24140689G>A	ENST00000374483.4	-	6	1084	c.413C>T	c.(412-414)tCt>tTt	p.S138F	HMGCL_ENST00000509389.1_Intron|HMGCL_ENST00000374490.3_Missense_Mutation_p.S163F|HMGCL_ENST00000436439.2_Intron			P35914	HMGCL_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase	163					acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)		CCCCCGCACAGAAATATTGGC	0.498000													29	68					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96021270	96021270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96021270C>T	ENST00000297954.4	+	11	2440	c.2440C>T	c.(2440-2442)Cct>Tct	p.P814S	WNK2_ENST00000395475.2_Missense_Mutation_p.P748S|WNK2_ENST00000427277.2_Missense_Mutation_p.P426S|WNK2_ENST00000349097.3_Missense_Mutation_p.P426S|WNK2_ENST00000395477.2_Missense_Mutation_p.P814S|WNK2_ENST00000356055.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	814					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CGACGGCCTCCCTCCGGCCCT	0.657000													21	60					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74692164	74692164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74692164C>T	ENST00000334011.5	+	9	1738	c.1520C>T	c.(1519-1521)tCc>tTc	p.S507F		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	507	ZP.					nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					GACGAGCGTTCCCGCTGTGCC	0.582000													56	157					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39974733	39974733	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39974733G>A	ENST00000321562.4	+	4	785	c.681G>A	c.(679-681)agG>agA	p.R227R		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	227	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GAGAGAGAAGGAAGATTATCA	0.557000													9	18					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105905313	105905313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105905313G>A	ENST00000357060.3	-	31	3980	c.3865C>T	c.(3865-3867)Cgc>Tgc	p.R1289C	WDR96_ENST00000428666.1_Missense_Mutation_p.R1261C	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1289										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TTAAAGCTGCGATCCATAACC	0.368000													11	43					0	0	1	0	0
FKBP3	2287	broad.mit.edu	37	14	45603624	45603624	+	Silent	SNP	C	C	T	rs28366026		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:45603624C>T	ENST00000216330.3	-	2	446	c.36G>A	c.(34-36)gtG>gtA	p.V12V	FKBP3_ENST00000396062.3_Silent_p.V12V			Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	12					protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity			NS(1)|biliary_tract(1)|endometrium(1)|large_intestine(2)|lung(6)|skin(1)	12						GCAGCTGCTCCACGGTCCACG	0.662000													21	79					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152531836	152531836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152531836G>A	ENST00000427231.2	-	35	4046	c.3844C>T	c.(3844-3846)Ctc>Ttc	p.L1282F	NEB_ENST00000409198.1_Missense_Mutation_p.L1282F|NEB_ENST00000397345.3_Missense_Mutation_p.L1282F|NEB_ENST00000604864.1_Missense_Mutation_p.L1282F|NEB_ENST00000172853.10_Missense_Mutation_p.L1282F|NEB_ENST00000603639.1_Missense_Mutation_p.L1282F	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1282					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTGGCCTGGAGAAACTGAGGA	0.373000													3	9					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45947202	45947202	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45947202G>A	ENST00000323084.4	-	7	1187	c.1122C>T	c.(1120-1122)gcC>gcT	p.A374A	TSPEAR_ENST00000397916.1_Silent_p.A306A	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	374					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						AATGCCTCCAGGCCTGTGCTT	0.562000													16	96					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64607671	64607671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64607671G>A	ENST00000342711.5	-	5	501	c.502C>T	c.(502-504)Ccg>Tcg	p.P168S		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	168	Protein kinase.		P -> L (in dbSNP:rs34454471).		actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						AGCTCGGGCGGGAGACGGTCC	0.642000													15	38					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30795606	30795606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30795606C>T	ENST00000383096.3	-	19	2168	c.1986G>A	c.(1984-1986)atG>atA	p.M662I	CCDC178_ENST00000402325.1_Missense_Mutation_p.M662I|CCDC178_ENST00000583930.1_Missense_Mutation_p.M662I|CCDC178_ENST00000406524.2_Missense_Mutation_p.M662I|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000579947.1_Missense_Mutation_p.M662I|CCDC178_ENST00000403303.1_Missense_Mutation_p.M662I|CCDC178_ENST00000300227.8_Missense_Mutation_p.M624I					coiled-coil domain containing 178									p.M624I(1)|p.M662I(1)									CATAAAAAATCATTGTCTTAC	0.254000													4	33					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18764911	18764911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18764911G>A	ENST00000358540.2	-	5	787	c.357C>T	c.(355-357)ctC>ctT	p.L119L	PTPN5_ENST00000477854.1_5'UTR|PTPN5_ENST00000396171.4_Silent_p.L119L|PTPN5_ENST00000396170.1_Intron|PTPN5_ENST00000496201.2_5'UTR|PTPN5_ENST00000396167.2_Intron|PTPN5_ENST00000396168.1_Silent_p.L95L	NM_006906.1	NP_008837.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	119						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						AAGAGGAGACGAGGTTTGTGG	0.592000													74	46					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186008003	186008003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186008003C>T	ENST00000271588.4	+	38	6123	c.5894C>T	c.(5893-5895)aCc>aTc	p.T1965I	HMCN1_ENST00000367492.2_Missense_Mutation_p.T1965I	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1965	Ig-like C2-type 17.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCAGGTTCCACCAGCATGACT	0.368000													50	123					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561502	145561502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145561502C>T	ENST00000355594.4	+	10	1277	c.1190C>T	c.(1189-1191)cCa>cTa	p.P397L		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	397										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACAGTAAATCCAGTATTAGCT	0.552000													18	54					0	0	1	0	0
YAE1D1	57002	broad.mit.edu	37	7	39611996	39611996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:39611996C>T	ENST00000223273.2	+	3	415	c.372C>T	c.(370-372)atC>atT	p.I124I	YAE1D1_ENST00000448268.1_3'UTR|YAE1D1_ENST00000432096.2_Intron	NM_020192.3	NP_064577.1	Q9NRH1	CG036_HUMAN	Yae1 domain containing 1	124																	TGAAATCAATCACTCCACCGT	0.368000													22	93					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6750866	6750866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6750866G>A	ENST00000378827.4	+	2	1312	c.93G>A	c.(91-93)agG>agA	p.R31R		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	31					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	TGGGCCGCAGGAAGTTCGCGG	0.692000													6	8					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66928483	66928483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66928483C>T	ENST00000269080.2	-	6	880	c.743G>A	c.(742-744)aGg>aAg	p.R248K	ABCA8_ENST00000586539.1_Missense_Mutation_p.R248K|ABCA8_ENST00000430352.2_Missense_Mutation_p.R248K	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	248						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					CATCCTTTTCCTCTCTCTTGT	0.388000													23	41					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475717	120475717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:120475717G>A	ENST00000355622.6	+	3	1412	c.1311G>A	c.(1309-1311)atG>atA	p.M437I	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.M397I	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	437					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TGAAACAAATGAGTGAGTTTT	0.378000													20	77					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96952165	96952165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96952165G>A	ENST00000323853.5	-	29	3964	c.3887C>T	c.(3886-3888)cCc>cTc	p.P1296L	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1296						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						GGTTGGAGGGGGGTACTTCTC	0.498000													33	101					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88258513	88258513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88258513C>T	ENST00000418177.2	-	9	3057	c.2690G>A	c.(2689-2691)gGg>gAg	p.G897E	GRM5_ENST00000305447.4_Missense_Mutation_p.G897E|GRM5_ENST00000393297.1_Intron|GRM5_ENST00000455756.2_Intron|GRM5_ENST00000305432.5_Intron			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	897					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CCCCATACTCCCTTTGGGGGT	0.483000													116	304					0	0	1	0	0
ANKRD6	22881	broad.mit.edu	37	6	90340157	90340157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:90340157G>A	ENST00000369408.5	+	15	1862	c.1513G>A	c.(1513-1515)Gac>Aac	p.D505N	ANKRD6_ENST00000522441.1_Missense_Mutation_p.D540N|LYRM2_ENST00000520441.1_Intron|ANKRD6_ENST00000520793.1_Missense_Mutation_p.D476N|ANKRD6_ENST00000339746.4_Missense_Mutation_p.D540N|ANKRD6_ENST00000447838.2_Missense_Mutation_p.D535N	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	540							protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		ACCAGGTGTGGACCAATTAGT	0.507000													14	26					0	0	1	0	0
B3GALTL	145173	broad.mit.edu	37	13	31835147	31835147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:31835147C>T	ENST00000343307.4	+	7	673	c.524C>T	c.(523-525)tCc>tTc	p.S175F	B3GALTL_ENST00000461652.2_3'UTR	NM_194318.3	NP_919299.3	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	175					fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		TATGCCTTTTCCGAGAATCCT	0.343000													14	58					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71825461	71825461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:71825461G>A	ENST00000373545.3	-	23	2876	c.2438C>T	c.(2437-2439)cCc>cTc	p.P813L	PHKA1_ENST00000373539.3_Missense_Mutation_p.P872L|PHKA1_ENST00000339490.3_Missense_Mutation_p.P872L|PHKA1_ENST00000373542.4_Missense_Mutation_p.P872L|PHKA1_ENST00000541944.1_Missense_Mutation_p.P813L			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	872	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CGCCTCATAGGGCAGAGGTCT	0.393000													15	17					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157528825	157528825	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:157528825C>T	ENST00000346085.5	+	20	6551	c.6550C>T	c.(6550-6552)Ccc>Tcc	p.P2184S	ARID1B_ENST00000350026.5_Missense_Mutation_p.P2171S|ARID1B_ENST00000367148.1_Missense_Mutation_p.P2224S|ARID1B_ENST00000275248.4_Missense_Mutation_p.P2166S	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2171					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity	p.P2168fs*6(1)		NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GCACATGCAGCCCCCGCCCCT	0.557000													35	52					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81769583	81769583	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81769583G>A	ENST00000550584.2	-	9	1418	c.1123C>T	c.(1123-1125)Ctg>Ttg	p.L375L	PPFIA2_ENST00000333447.7_Silent_p.L357L|PPFIA2_ENST00000545296.2_5'UTR|PPFIA2_ENST00000549325.1_Silent_p.L357L|PPFIA2_ENST00000552948.1_Silent_p.L375L|PPFIA2_ENST00000548586.1_Silent_p.L375L|PPFIA2_ENST00000407050.4_Silent_p.L301L|PPFIA2_ENST00000550359.2_Silent_p.L222L|PPFIA2_ENST00000443686.3_Silent_p.L276L|PPFIA2_ENST00000549396.1_Silent_p.L375L	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	301										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ACCTGCCGCAGGATAGCTTCT	0.398000													11	27					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7581550	7581550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7581550C>T	ENST00000379802.3	+	23	5468	c.5127C>T	c.(5125-5127)ctC>ctT	p.L1709L	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1709	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGCAGTCTCTCACAGAGAACC	0.463000													18	125					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31541429	31541429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31541429C>T	ENST00000454783.1	+	4	835	c.577C>T	c.(577-579)Ctc>Ttc	p.L193F	LTA_ENST00000418386.2_Missense_Mutation_p.L193F	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	193					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	CCACCTAGTCCTCAGCCCTAG	0.522000													79	186					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590670	156590670	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156590670C>T	ENST00000302938.4	-	2	702		c.e2-1			NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B							nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCTCTGCAGCCTATACCAAGG	0.483000													32	70					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44146425	44146425	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44146425C>T	ENST00000223357.3	+	2	839	c.534C>T	c.(532-534)acC>acT	p.T178T		NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	178	Pro-rich.				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						CCTCAGAAACCCTGGAGTGGC	0.667000													8	21					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84243513	84243513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:84243513G>A	ENST00000405413.2	-	3	368	c.232C>T	c.(232-234)Cca>Tca	p.P78S	HPSE_ENST00000311412.5_Missense_Mutation_p.P78S|HPSE_ENST00000513463.1_Missense_Mutation_p.P78S|HPSE_ENST00000512196.1_Missense_Mutation_p.P78S	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	78					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	CGAAGCTTTGGAGAACTGTTA	0.423000													12	21					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88476386	88476386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:88476386C>T	ENST00000394480.1	-	16	2067	c.1746G>A	c.(1744-1746)cgG>cgA	p.R582R	NTRK3_ENST00000558676.1_Silent_p.R574R|NTRK3_ENST00000357724.2_Silent_p.R574R|NTRK3_ENST00000355254.2_Silent_p.R582R|NTRK3_ENST00000542733.2_Silent_p.R484R|NTRK3_ENST00000360948.2_Silent_p.R582R|NTRK3_ENST00000557856.1_Silent_p.R574R	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	582	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGAAATCCTTCCGGGCAGCCA	0.567000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			51	49					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109513549	109513549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:109513549C>T	ENST00000409271.1	-	12	1700	c.1257G>A	c.(1255-1257)gaG>gaA	p.E419E	EDAR_ENST00000258443.2_Silent_p.E387E|EDAR_ENST00000376651.1_Silent_p.E419E			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	387	Death.				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TGCCCCCAATCTCATCCCTCT	0.562000													11	44					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662562	662562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:662562C>T	ENST00000266383.5	+	14	1486	c.1473C>T	c.(1471-1473)tcC>tcT	p.S491S		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	491						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			CCCCCTTCTCCAAGCGGAACT	0.642000													9	91					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584156	179584156	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179584156G>A	ENST00000589042.1	-	83	24185	c.23961C>T	c.(23959-23961)ttC>ttT	p.F7987F	TTN_ENST00000342992.6_Silent_p.F6743F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.F7670F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7670	Ig-like 62.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTGCGGATGAAGGAAGGAG	0.502000													24	85					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072414	9072414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9072414G>A	ENST00000397910.4	-	3	15235	c.15032C>T	c.(15031-15033)tCa>tTa	p.S5011L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5013	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATCCAATTGTGAAAATCCATG	0.483000													9	71					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103142759	103142759	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103142759G>A	ENST00000295269.4	+	11	2449	c.1992G>A	c.(1990-1992)ggG>ggA	p.G664G		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	664					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						ACCCCTACGGGAATCCTCAGT	0.502000													38	92					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164506928	164506928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164506928C>T	ENST00000503008.1	-	6	1372	c.396G>A	c.(394-396)atG>atA	p.M132I	MARCH1_ENST00000514618.1_Missense_Mutation_p.M388I|MARCH1_ENST00000274056.7_Missense_Mutation_p.M132I|MARCH1_ENST00000339875.5_Missense_Mutation_p.M115I	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	132					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GCTTGGTCTCCATTATGAAGT	0.483000													35	80					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107423262	107423262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107423262C>T	ENST00000409382.3	-	6	2072	c.1462G>A	c.(1462-1464)Gag>Aag	p.E488K	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.E488K	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	488					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						AGGAGCTTCTCATAGAGTAGT	0.617000													24	65					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13381426	13381426	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13381426G>A	ENST00000254508.5	-	25	3481	c.3399C>T	c.(3397-3399)atC>atT	p.I1133I	NUP210_ENST00000485755.1_5'UTR	NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1133					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TGCCGTTCCCGATGGCGAGGC	0.622000													44	157					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7709559	7709559	+	Silent	SNP	C	C	T	rs139160342	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7709559C>T	ENST00000441779.2	+	14	1237	c.1200C>T	c.(1198-1200)atC>atT	p.I400I	STXBP2_ENST00000414284.2_Silent_p.I386I|STXBP2_ENST00000221283.5_Silent_p.I389I	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	389					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						TGAAGCTGATCGTTCCGGTGC	0.657000													22	47					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11545877	11545877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11545877C>T	ENST00000389362.4	-	3	1170	c.1135G>A	c.(1135-1137)Ggt>Agt	p.G379S	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGTGGGGGACCTTGAGGATTG	0.632000													49	140					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832220	61832220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61832220C>T	ENST00000280772.1	-	37	8610	c.8419G>A	c.(8419-8421)Gat>Aat	p.D2807N	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2807					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTCACATTATCAGAGCCAGAA	0.373000													36	78					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22872489	22872489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22872489C>T	ENST00000283645.4	+	22	3148	c.3018C>T	c.(3016-3018)tcC>tcT	p.S1006S	TUBGCP5_ENST00000453949.2_Silent_p.S1006S	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	1006					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GTAGAGGATCCTTTCCCCATT	0.323000													26	115					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149879672	149879672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149879672C>T	ENST00000369146.3	-	9	1956	c.1466G>A	c.(1465-1467)gGg>gAg	p.G489E	SV2A_ENST00000369145.1_Missense_Mutation_p.G489E	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	489					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TACGCGCTCCCCGGGGAACAC	0.517000													49	134					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160482654	160482654	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:160482654C>T	ENST00000356956.1	+	24	3530	c.3382C>T	c.(3382-3384)Ctc>Ttc	p.L1128F		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1128					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TTGCAATCCTCTCCCTTACAT	0.493000													47	58					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78933433	78933433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78933433G>A	ENST00000261751.3	-	1	154	c.43C>T	c.(43-45)Ctt>Ttt	p.L15F	CHRNB4_ENST00000412074.2_Missense_Mutation_p.L15F|CHRNB4_ENST00000560511.1_Intron	NM_000750.3	NP_000741.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	15					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CGCCCGCAAAGGGCGACCAGG	0.711000													7	16					0	0	1	0	0
GCM1	8521	broad.mit.edu	37	6	52999086	52999086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:52999086C>T	ENST00000259803.7	-	3	323	c.112G>A	c.(112-114)Gat>Aat	p.D38N		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	38						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					GCATAGGAATCTGGCCACTCC	0.493000													9	107					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495547	71495547	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71495547C>T	ENST00000296755.7	+	5	6663	c.6365C>T	c.(6364-6366)cCc>cTc	p.P2122L		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2122						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TCTGAAAAGCCCCTCACTCAA	0.542000													58	129					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881273	142881273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142881273G>A	ENST00000446620.1	+	1	762	c.762G>A	c.(760-762)atG>atA	p.M254I		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	254					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					ACCCCAGCATGGAGGCTCACA	0.488000													38	126					0	0	1	0	0
ALG10B	144245	broad.mit.edu	37	12	38714175	38714175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:38714175C>T	ENST00000308742.4	+	3	898	c.582C>T	c.(580-582)gtC>gtT	p.V194V	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	194					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				TCTGGGCTGTCTTCTGTGCAG	0.388000													45	287					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161013	90161013	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:90161013C>T	ENST00000564451.1	+	0	894				TUBB8P7_ENST00000567960.1_RNA																							CGGGGCCCTTCGGGCAGGTCT	0.667000													24	61					0	0	1	0	0
CLDN10	9071	broad.mit.edu	37	13	96205054	96205054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:96205054C>T	ENST00000299339.2	+	1	76	c.47C>T	c.(46-48)tCa>tTa	p.S16L	CLDN10_ENST00000376873.3_Intron	NM_006984.4	NP_008915.1	P78369	CLD10_HUMAN	claudin 10	16					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			GTCTCCATCTCAGGCTGGGTA	0.652000													12	33					0	0	1	0	0
MMD	23531	broad.mit.edu	37	17	53488740	53488740	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:53488740G>A	ENST00000262065.3	-	3	443	c.147C>T	c.(145-147)ctC>ctT	p.L49L		NM_012329.2	NP_036461.2	Q15546	PAQRB_HUMAN	monocyte to macrophage differentiation-associated	49					cytolysis	integral to plasma membrane|late endosome membrane|lysosomal membrane|membrane fraction	receptor activity			breast(1)|large_intestine(1)|lung(4)|prostate(1)	7						ACAGCCGATGGAGGAGGGCAC	0.438000													8	48					0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101718929	101718929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101718929G>A	ENST00000318607.5	-	11	2680	c.1552C>T	c.(1552-1554)Cgc>Tgc	p.R518C	PABPC1_ENST00000522387.1_Missense_Mutation_p.R486C|PABPC1_ENST00000519004.1_Missense_Mutation_p.R473C|PABPC1_ENST00000519596.1_5'UTR	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	518					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			TGAGGATTGCGAACTCCTGCA	0.453000													36	74					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77257578	77257578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77257578C>T	ENST00000376896.2	+	4	1096	c.484C>T	c.(484-486)Cag>Tag	p.Q162*	RORB_ENST00000396204.2_Nonsense_Mutation_p.Q173*	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	173	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.Q162*(1)		breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						CGATTCCGGTCAGCCGTCCCC	0.507000													18	32					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57194407	57194407	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57194407C>T	ENST00000331162.4	-	3	328	c.58G>A	c.(58-60)Gac>Aac	p.D20N		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			ATAGCTATGTCTCTGAATGTC	0.413000													11	94					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19748171	19748171	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:19748171G>A	ENST00000400113.3	-	5	1289	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	395					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ACATGAGATCGAACTTATGGT	0.642000													57	158					0	0	1	0	0
UPK3A	7380	broad.mit.edu	37	22	45685012	45685012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45685012C>T	ENST00000216211.4	+	4	591	c.559C>T	c.(559-561)Cgc>Tgc	p.R187C	UPK3A_ENST00000396082.2_Intron	NM_006953.3	NP_008884.1	O75631	UPK3A_HUMAN	uroplakin 3A	187					epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane				kidney(1)|large_intestine(1)|lung(2)|skin(1)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		AGACCCCATCCGCACCAACCA	0.602000													18	97					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277031	152277031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152277031C>T	ENST00000368799.1	-	3	10366	c.10331G>A	c.(10330-10332)gGa>gAa	p.G3444E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3444	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCCTGCCTTCCTCTTCTGCT	0.602000									Ichthyosis				162	415					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43439744	43439744	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43439744G>A	ENST00000446844.3	-	0	331				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TACTATATATGATGTAACATA	0.423000													88	329					0	0	1	0	0
MSI1	4440	broad.mit.edu	37	12	120785268	120785268	+	Silent	SNP	C	C	T	rs141481855	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120785268C>T	ENST00000257552.2	-	12	928	c.840G>A	c.(838-840)gcG>gcA	p.A280A		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	280	Poly-Ala.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GAACCACAGCCGCTGCCGCCG	0.627000													35	173					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65396366	65396366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65396366C>T	ENST00000355703.3	+	24	4427	c.3888C>T	c.(3886-3888)gcC>gcT	p.A1296A		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1296						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						TAGGCAGTGCCGTCTTCATCA	0.632000													11	24					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102964547	102964547	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102964547G>A	ENST00000233954.1	+	9	1384	c.1113G>A	c.(1111-1113)agG>agA	p.R371R		NM_016232.4	NP_057316.3	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	371					innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						ACAAGACTAGGAATGGTAAGT	0.378000													30	50					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34052145	34052145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34052145C>T	ENST00000373381.4	-	46	7186	c.7010G>A	c.(7009-7011)gGa>gAa	p.G2337E		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2339	Sushi 13.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CAGGTAGGTTCCAAGTTTGCA	0.488000													17	67					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42915959	42915959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42915959C>T	ENST00000316161.4	-	1	1674	c.1350G>A	c.(1348-1350)gtG>gtA	p.V450V	ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Intron	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	450					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		TAAAGAGCTTCACCTCACTGA	0.537000													25	48					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169819815	169819815	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169819815G>A	ENST00000335742.7	+	14	3254	c.1897G>A	c.(1897-1899)Gga>Aga	p.G633R	CBR4_ENST00000509108.1_Intron|PALLD_ENST00000512127.1_Missense_Mutation_p.G409R|PALLD_ENST00000261509.6_Missense_Mutation_p.G791R|PALLD_ENST00000507735.1_Missense_Mutation_p.G304R|PALLD_ENST00000505667.1_Missense_Mutation_p.G808R			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	1015					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GATCTTTGAGGGAATGCCAGT	0.433000									Pancreatic Cancer, Familial Clustering of				19	75					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22890763	22890763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22890763G>A	ENST00000543184.1	-	5	2118	c.1256C>T	c.(1255-1257)tCc>tTc	p.S419F	PRAME_ENST00000402697.1_Missense_Mutation_p.S419F|PRAME_ENST00000539862.1_Missense_Mutation_p.S403F|PRAME_ENST00000405655.3_Missense_Mutation_p.S419F|PRAME_ENST00000424204.2_Missense_Mutation_p.S403F|PRAME_ENST00000398743.2_Missense_Mutation_p.S419F|PRAME_ENST00000398741.1_Missense_Mutation_p.S419F	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	419	Mediates interaction with RARA.				apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		GGCAGATATGGAGATGGAATT	0.547000													17	49					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885275	88885275	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:88885275C>T	ENST00000319675.3	-	1	1021	c.925G>A	c.(925-927)Gaa>Aaa	p.E309K		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	309										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						ACATGACCTTCGTACTGTGTT	0.517000													13	71					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690528	33690528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33690528C>T	ENST00000394566.1	-	4	571	c.299G>A	c.(298-300)gGa>gAa	p.G100E	SLFN11_ENST00000308377.4_Missense_Mutation_p.G100E	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	100						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAAACACCTTCCTTGTTGCTT	0.458000													19	58					0	0	1	0	0
DOK5	55816	broad.mit.edu	37	20	53205055	53205055	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:53205055C>T	ENST00000262593.5	+	3	558	c.208C>T	c.(208-210)Cga>Tga	p.R70*	DOK5_ENST00000395939.1_5'UTR	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	70	PH.						insulin receptor binding	p.R70G(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			GAACGTAGCTCGATTGCCAAA	0.408000													59	133					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57865804	57865804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57865804C>T	ENST00000228682.2	+	12	3372	c.3281C>T	c.(3280-3282)tCc>tTc	p.S1094F	GLI1_ENST00000543426.1_Missense_Mutation_p.S966F|GLI1_ENST00000546141.1_Missense_Mutation_p.S1053F	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	1094					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding	p.S1094F(2)		NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			TTACTGAGATCCCTACCTGGG	0.532000													30	94					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68912536	68912536	+	Silent	SNP	G	G	A	rs146357166	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:68912536G>A	ENST00000262340.5	-	3	155	c.102C>T	c.(100-102)atC>atT	p.I34I		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	34					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						GCCAGAGGGGGATCCTGCCTG	0.542000													21	68					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152787119	152787119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152787119G>A	ENST00000367255.5	-	17	2328	c.1727C>T	c.(1726-1728)tCa>tTa	p.S576L	SYNE1_ENST00000466159.2_Missense_Mutation_p.S576L|SYNE1_ENST00000495090.2_Missense_Mutation_p.S143L|SYNE1_ENST00000341594.5_Missense_Mutation_p.S583L|SYNE1_ENST00000367248.3_Missense_Mutation_p.S566L|SYNE1_ENST00000423061.1_Missense_Mutation_p.S583L|SYNE1_ENST00000448038.1_Missense_Mutation_p.S583L|SYNE1_ENST00000265368.4_Missense_Mutation_p.S576L|SYNE1_ENST00000413186.2_Missense_Mutation_p.S576L|SYNE1_ENST00000367253.4_Missense_Mutation_p.S576L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	576					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGTTTTACCTGAACCATCTGC	0.373000										HNSCC(10;0.0054)			22	27					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33585816	33585816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33585816G>A	ENST00000404816.2	+	27	4506	c.4153G>A	c.(4153-4155)Gaa>Aaa	p.E1385K	LTBP1_ENST00000402934.1_Missense_Mutation_p.E1004K|LTBP1_ENST00000354476.3_Missense_Mutation_p.E1386K|LTBP1_ENST00000404525.1_Missense_Mutation_p.E1006K|LTBP1_ENST00000407925.1_Missense_Mutation_p.E1059K|LTBP1_ENST00000272273.5_Missense_Mutation_p.E283K|LTBP1_ENST00000390003.4_Missense_Mutation_p.E1060K|LTBP1_ENST00000418533.2_Missense_Mutation_p.E1017K			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1385	TB 3.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGATAACTGCGAAATCTTCCC	0.498000													5	74					0	0	1	0	0
TMEM40	55287	broad.mit.edu	37	3	12780058	12780058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12780058C>T	ENST00000314124.7	-	6	741	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K	TMEM40_ENST00000264728.8_Missense_Mutation_p.E129K|TMEM40_ENST00000435218.2_Missense_Mutation_p.E99K|TMEM40_ENST00000435575.1_Missense_Mutation_p.E53K|TMEM40_ENST00000431022.2_Missense_Mutation_p.E145K|TMEM40_ENST00000476331.1_5'UTR	NM_018306.2	NP_060776.2	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	129						integral to membrane				breast(1)|large_intestine(3)|lung(5)|urinary_tract(1)	10						TCACCTGATTCCCCAGAGGGT	0.547000													36	102					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116339546	116339546	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:116339546C>T	ENST00000397752.3	+	2	608	c.408C>T	c.(406-408)gtC>gtT	p.V136V	MET_ENST00000318493.6_Silent_p.V136V|MET_ENST00000436117.2_Silent_p.V136V	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	136	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			GTGGCAGCGTCAACAGAGGGA	0.473000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				17	174					0	0	1	0	0
KRT23	25984	broad.mit.edu	37	17	39092585	39092585	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39092585G>A	ENST00000209718.3	-	2	695	c.271C>T	c.(271-273)Cgc>Tgc	p.R91C	AC004231.2_ENST00000418393.1_RNA|KRT23_ENST00000436344.3_Intron	NM_015515.3	NP_056330.3	Q9C075	K1C23_HUMAN	keratin 23 (histone deacetylase inducible)	91	Coil 1A.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000301)|Ovarian(249;0.15)				TCCAGGGCGCGAACCTTCTCC	0.557000													55	98					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039058	11039058	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039058C>T	ENST00000470054.1	-	0	1145									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCATCAATCCAGTAGAAAGT	0.398000													71	706					0	0	1	0	0
CSNK2A3	283106	broad.mit.edu	37	11	11373680	11373680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:11373680C>T	ENST00000528848.2	-	1	1224	c.987G>A	c.(985-987)aaG>aaA	p.K329K	GALNT18_ENST00000227756.4_Intron	NM_001256686.1	NP_001243615.1			casein kinase 2, alpha 3 polypeptide																		GAGCCTGGTCCTTCACAACAG	0.542000													25	96					0	0	1	0	0
CALML3	810	broad.mit.edu	37	10	5567368	5567368	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5567368G>A	ENST00000315238.1	+	1	445	c.320G>A	c.(319-321)cGa>cAa	p.R107Q	CALML3-AS1_ENST00000545372.1_RNA|RP11-116G8.5_ENST00000442008.2_RNA|CALML3-AS1_ENST00000542093.1_RNA	NM_005185.2	NP_005176.1	P27482	CALL3_HUMAN	calmodulin-like 3	107	EF-hand 3.						calcium ion binding			endometrium(3)|lung(2)	5						GCCGAGCTGCGACACGTCATG	0.647000													17	31					0	0	1	0	0
WDR86	349136	broad.mit.edu	37	7	151097249	151097249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151097249C>T	ENST00000334493.6	-	2	672	c.242G>A	c.(241-243)aGg>aAg	p.R81K	WDR86_ENST00000477459.1_5'UTR|WDR86_ENST00000469830.2_Missense_Mutation_p.R81K	NM_198285.2	NP_938026.2	Q86TI4	WDR86_HUMAN	WD repeat domain 86	81										breast(1)|endometrium(2)|kidney(1)|lung(6)	10			OV - Ovarian serous cystadenocarcinoma(82;0.00419)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACGTCCCACCTCCTGATGGT	0.607000													6	15					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131186710	131186710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:131186710G>A	ENST00000337057.3	-	17	2976	c.2795C>T	c.(2794-2796)tCc>tTc	p.S932F	EPB41L2_ENST00000530757.1_Intron|EPB41L2_ENST00000525271.1_Intron|EPB41L2_ENST00000525193.1_Missense_Mutation_p.S633F|EPB41L2_ENST00000392427.3_Intron|EPB41L2_ENST00000531410.1_Missense_Mutation_p.S53F|EPB41L2_ENST00000527659.1_Missense_Mutation_p.S738F|EPB41L2_ENST00000528282.1_Missense_Mutation_p.S674F|EPB41L2_ENST00000530481.1_Missense_Mutation_p.S779F|EPB41L2_ENST00000445890.2_Missense_Mutation_p.S674F|EPB41L2_ENST00000524581.1_Missense_Mutation_p.S310F|EPB41L2_ENST00000527411.1_Missense_Mutation_p.S862F|EPB41L2_ENST00000368128.2_Missense_Mutation_p.S932F|EPB41L2_ENST00000529208.1_Missense_Mutation_p.S862F	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	932	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity	p.S932F(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TGTTGACACGGACTCAGATGT	0.458000													19	48					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6062203	6062203	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6062203C>T	ENST00000409021.3	-	11	2041	c.1592G>A	c.(1591-1593)aGg>aAg	p.R531K	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.R366K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.R531K|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.R531K|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.R346K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	531	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GGCCTGACACCTCAGCAGATC	0.527000													37	129					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57771017	57771017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57771017C>T	ENST00000371030.2	+	2	3832	c.3832C>T	c.(3832-3834)Cgt>Tgt	p.R1278C		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1278						intracellular	nucleic acid binding|zinc ion binding	p.R1278C(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AAAGATGTCTCGTGGGAACAG	0.498000													36	147					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123596828	123596828	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123596828G>A	ENST00000336139.4	-	8	2186	c.1824C>T	c.(1822-1824)ctC>ctT	p.L608L	ZNF202_ENST00000530393.1_Silent_p.L608L|ZNF202_ENST00000529691.1_Silent_p.L608L			O95125	ZN202_HUMAN	zinc finger protein 202	608					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		GATGCCTGACGAGGTGGTCCC	0.552000													28	81					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107022182	107022182	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:107022182A>T	ENST00000369701.3	+	26	3764	c.3537A>T	c.(3535-3537)aaA>aaT	p.K1179N		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1179						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACGCCCCCAAAATCACACTCA	0.507000													21	52					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52682524	52682524	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52682524G>A	ENST00000355568.4	-	8	623	c.484C>T	c.(484-486)Cga>Tga	p.R162*		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	162	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity	p.R219*(1)		breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		ATACAAGTTCGAGCAAGTTCC	0.333000													33	65					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55912417	55912417	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:55912417G>A	ENST00000389286.4	-	20	3293	c.3246C>T	c.(3244-3246)acC>acT	p.T1082T		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	1082					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TTAATACAGTGGTGCCTGGCT	0.468000													32	87					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186445088	186445088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186445088G>A	ENST00000265023.4	+	5	839	c.627G>A	c.(625-627)gaG>gaA	p.E209E	KNG1_ENST00000287611.2_Silent_p.E209E|KNG1_ENST00000447445.1_Intron|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	209	Cystatin 2.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GTTCCAAAGAGAATTTTCTGT	0.343000													10	107					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163302789	163302789	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163302789G>A	ENST00000332142.5	-	7	1392	c.1293C>T	c.(1291-1293)ttC>ttT	p.F431F	KCNH7_ENST00000328032.4_Silent_p.F424F	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	431					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CATTGAGGAGGAAGGCTGCAG	0.423000													24	64					0	0	1	0	0
TTYH1	57348	broad.mit.edu	37	19	54930377	54930377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54930377C>T	ENST00000301194.4	+	2	324	c.202C>T	c.(202-204)Cgc>Tgc	p.R68C	TTYH1_ENST00000376530.3_Missense_Mutation_p.R68C|TTYH1_ENST00000376531.3_Missense_Mutation_p.R68C|TTYH1_ENST00000391739.3_Missense_Mutation_p.R117C			Q9H313	TTYH1_HUMAN	tweety family member 1	68					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		CTACCTCATCCGCTTCTGCTG	0.687000													35	97					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111078277	111078277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111078277C>T	ENST00000551590.1	+	8	1089	c.933C>T	c.(931-933)ctC>ctT	p.L311L	TCTN1_ENST00000551555.2_3'UTR|TCTN1_ENST00000377654.3_Silent_p.L133L|TCTN1_ENST00000397655.3_Silent_p.L297L|TCTN1_ENST00000397659.4_Silent_p.L311L|HVCN1_ENST00000548312.1_Intron			Q2MV58	TECT1_HUMAN	tectonic family member 1	311					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						AGCCGACTCTCGTCAACGCTG	0.507000													28	52					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702859	181702859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181702859C>T	ENST00000526775.1	+	20	3343	c.3178C>T	c.(3178-3180)Ccc>Tcc	p.P1060S	CACNA1E_ENST00000367567.4_Missense_Mutation_p.P686S|CACNA1E_ENST00000358338.5_Missense_Mutation_p.P1011S|CACNA1E_ENST00000367570.1_Missense_Mutation_p.P1079S|CACNA1E_ENST00000360108.3_Missense_Mutation_p.P1060S|CACNA1E_ENST00000367573.2_Missense_Mutation_p.P1079S|CACNA1E_ENST00000357570.5_Missense_Mutation_p.P1030S	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1079					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CGACGTGGACCCCTTGGTGGA	0.627000													10	39					0	0	1	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998360	8998360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8998360G>A	ENST00000310455.3	-	2	952	c.802C>T	c.(802-804)Ctg>Ttg	p.L268L	PPP1R3B_ENST00000519699.1_Silent_p.L268L	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	268					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		TCTGGAAACAGACCATAGGAA	0.532000													16	41					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103907979	103907979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103907979C>T	ENST00000302259.3	+	1	672	c.429C>T	c.(427-429)ccC>ccT	p.P143P	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	143					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGGGCAGCCCCGCCCTGATCC	0.672000													19	42					0	0	1	0	0
GABRG3	2567	broad.mit.edu	37	15	27571983	27571983	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:27571983C>T	ENST00000333743.6	+	4	552	c.298C>T	c.(298-300)Cag>Tag	p.Q100*	GABRG3_ENST00000555083.1_Nonsense_Mutation_p.Q100*	NM_033223.4	NP_150092.2	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	100					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		ATTTTTTGCTCAGACCTGGAC	0.388000													46	92					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287109	202287109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202287109G>A	ENST00000367278.3	+	18	1767	c.1678G>A	c.(1678-1680)Gaa>Aaa	p.E560K	LGR6_ENST00000439764.2_Missense_Mutation_p.E421K|LGR6_ENST00000255432.7_Missense_Mutation_p.E508K	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	560						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						GTACCTCTTTGAAAGCTGGGG	0.612000													35	82					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86386565	86386565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:86386565C>T	ENST00000285379.5	+	4	594	c.364C>T	c.(364-366)Cac>Tac	p.H122Y		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	122					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TCACTTGGTTCACTGGAACAC	0.408000													67	149					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111789272	111789272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:111789272C>T	ENST00000389811.4	+	16	1664	c.1440C>T	c.(1438-1440)tcC>tcT	p.S480S	ACOXL_ENST00000439055.1_Silent_p.S450S			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	480					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						CTTCTCTGTCCCTGGCACACA	0.502000													19	65					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76826243	76826243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76826243C>T	ENST00000248598.5	-	2	705	c.673G>A	c.(673-675)Gag>Aag	p.E225K	RP11-467H10.2_ENST00000459742.1_RNA|CCDC146_ENST00000431197.1_Intron|CCDC146_ENST00000285871.4_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	225	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						CTGTAGGTCTCACTGCTTCTT	0.428000													43	133					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179453325	179453325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179453325C>T	ENST00000589042.1	-	304	63351	c.63127G>A	c.(63127-63129)Gaa>Aaa	p.E21043K	TTN_ENST00000342992.6_Missense_Mutation_p.E18475K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E11978K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E12170K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E12103K|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E19402K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19402	Fibronectin type-III 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCCAATTTCATTTTCTGCC	0.448000													98	228					0	0	1	0	0
BTBD3	22903	broad.mit.edu	37	20	11903963	11903963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:11903963C>T	ENST00000405977.1	+	5	1843	c.1218C>T	c.(1216-1218)ttC>ttT	p.F406F	BTBD3_ENST00000399006.2_Silent_p.F345F|BTBD3_ENST00000378226.2_Silent_p.F406F|BTBD3_ENST00000254977.3_Silent_p.F345F			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	406										breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						AAAGAGTGTTCATTGCTGGCT	0.522000													23	55					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25701903	25701903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:25701903G>A	ENST00000349320.3	-	10	1430	c.1042C>T	c.(1042-1044)Ctc>Ttc	p.L348F	RHCE_ENST00000413854.1_Intron|RHCE_ENST00000425135.1_Missense_Mutation_p.P273L|RHCE_ENST00000243186.6_Intron|RHCE_ENST00000340849.4_Intron|RHCE_ENST00000349438.4_Missense_Mutation_p.P319L|RHCE_ENST00000294413.7_Missense_Mutation_p.L364F|RHCE_ENST00000346452.4_Missense_Mutation_p.L213F|RHCE_ENST00000455194.1_Missense_Mutation_p.L259F|RHCE_ENST00000374352.2_Missense_Mutation_p.L348F			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	364						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		ATGCTGAGGAGGACCTGGAAG	0.542000													35	163					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678234	100678234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100678234C>T	ENST00000306151.4	+	3	3601	c.3537C>T	c.(3535-3537)acC>acT	p.T1179T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1179	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGGCTAACACCCTTTCAACAA	0.522000													110	479					0	0	1	0	0
ORM2	5005	broad.mit.edu	37	9	117094122	117094122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117094122G>A	ENST00000431067.2	+	5	489	c.453G>A	c.(451-453)acG>acA	p.T151T	ORM2_ENST00000412657.1_3'UTR	NM_000608.2	NP_000599.1			orosomucoid 2											breast(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(1)	7		Myeloproliferative disorder(63;0.163)				AGCCAGAGACGACCAAGGAGC	0.607000													13	32					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240071520	240071520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240071520G>A	ENST00000255380.4	+	5	1548	c.769G>A	c.(769-771)Gaa>Aaa	p.E257K		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	257					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GATCTATAAGGAAACTGAAAA	0.483000													32	88					0	0	1	0	0
FAM159A	348378	broad.mit.edu	37	1	53122628	53122628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53122628G>A	ENST00000517870.1	+	3	639	c.489G>A	c.(487-489)atG>atA	p.M163I	FAM159A_ENST00000401050.3_Intron	NM_001042693.1	NP_001036158.1	Q6UWV7	F159A_HUMAN	family with sequence similarity 159, member A	163						integral to membrane				endometrium(3)|lung(6)|upper_aerodigestive_tract(1)	10						ATTGCTTCATGGCCACAGTGA	0.542000													22	256					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	961030	961030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:961030G>A	ENST00000262301.11	-	4	582	c.564C>T	c.(562-564)tgC>tgT	p.C188C	LMF1_ENST00000543238.1_Intron|LMF1_ENST00000568897.1_5'UTR|LMF1_ENST00000539379.1_3'UTR|LMF1_ENST00000399843.2_Silent_p.C188C	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	188						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				TCCACAGAGGGCACAGGAAGA	0.557000													12	27					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182392099	182392099	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182392099G>A	ENST00000397033.2	+	22	2845	c.2415G>A	c.(2413-2415)atG>atA	p.M805I		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	805					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGGAGAAAATGAACTTAACTT	0.333000													19	62					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33133532	33133532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33133532G>A	ENST00000341947.2	-	63	4771	c.4544C>T	c.(4543-4545)tCg>tTg	p.S1515L	COL11A2_ENST00000357486.1_Missense_Mutation_p.S1494L|COL11A2_ENST00000361917.1_Missense_Mutation_p.S1408L|COL11A2_ENST00000374708.4_Missense_Mutation_p.S1429L|COL11A2_ENST00000395197.1_Missense_Mutation_p.S1455L|COL11A2_ENST00000374712.1_Missense_Mutation_p.S1434L|COL11A2_ENST00000374713.1_Missense_Mutation_p.S1468L|COL11A2_ENST00000477772.1_5'UTR|COL11A2_ENST00000374714.1_Missense_Mutation_p.S1489L	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1515					cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCCATCCACCGAGCGCCGAGT	0.637000													35	83					0	0	1	0	0
KRT6C	286887	broad.mit.edu	37	12	52862934	52862934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52862934C>T	ENST00000252250.6	-	9	1654	c.1607G>A	c.(1606-1608)gGg>gAg	p.G536E		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	536	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GAGGCCACCCCCAATGGCTCT	0.592000													22	69					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31815971	31815971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:31815971G>A	ENST00000446923.2	+	9	3497	c.3106G>A	c.(3106-3108)Gaa>Aaa	p.E1036K	ZEB1_ENST00000361642.5_Missense_Mutation_p.E1053K|ZEB1_ENST00000542815.3_Missense_Mutation_p.E985K|ZEB1_ENST00000320985.10_Missense_Mutation_p.E1052K|ZEB1_ENST00000560721.2_Missense_Mutation_p.E1032K	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1052	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				agaattgcaggaagaaaaaga	0.473000													5	15					0	0	1	0	0
FADS2	9415	broad.mit.edu	37	11	61596039	61596039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61596039C>T	ENST00000278840.4	+	1	807	c.177C>T	c.(175-177)gtC>gtT	p.V59V	FADS2_ENST00000521849.1_Silent_p.V59V|FADS2_ENST00000257261.6_Intron|FADS2_ENST00000522056.1_Intron	NM_004265.2	NP_004256.1	O95864	FADS2_HUMAN	fatty acid desaturase 2	59	Cytochrome b5 heme-binding.				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	GCCAGCGGGTCATCGGGCACT	0.622000											OREG0021015	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	27					0	0	1	0	0
OR52E2	119678	broad.mit.edu	37	11	5080361	5080361	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5080361A>C	ENST00000321522.2	-	1	496	c.497T>G	c.(496-498)tTg>tGg	p.L166W		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGGCAACCGCAATATAAGAAG	0.423000													7	24					0	0	1	0	0
ANO8	57719	broad.mit.edu	37	19	17442179	17442179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17442179G>A	ENST00000159087.4	-	6	786	c.628C>T	c.(628-630)Cct>Tct	p.P210S		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	210						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						TCGTGGACAGGGAACACCTGC	0.637000													17	75					0	0	1	0	0
PRSS12	8492	broad.mit.edu	37	4	119256682	119256682	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119256682C>T	ENST00000296498.3	-	3	1048	c.766G>A	c.(766-768)Ggt>Agt	p.G256S		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	256	SRCR 1.					membrane	scavenger receptor activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						CACACCCCACCCTGCCAGATG	0.423000													37	95					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124345682	124345682	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124345682G>A	ENST00000409039.3	+	38	6544	c.6519G>A	c.(6517-6519)agG>agA	p.R2173R		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2173	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACATCTTCAGGGAAATCAACA	0.453000													12	20					0	0	1	0	0
SMYD2	56950	broad.mit.edu	37	1	214504346	214504346	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:214504346C>T	ENST00000366957.5	+	9	892	c.870C>T	c.(868-870)gcC>gcT	p.A290A	SMYD2_ENST00000491455.1_3'UTR|SMYD2_ENST00000415093.2_Intron	NM_020197.2	NP_064582.2	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	290					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding	p.A290A(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		AGGCAGAAGCCATCCGAGACA	0.502000													48	113					0	0	1	0	0
CXCR6	10663	broad.mit.edu	37	3	45988648	45988648	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45988648G>A	ENST00000458629.1	+	1	2138	c.675G>A	c.(673-675)caG>caA	p.Q225Q	FYCO1_ENST00000438446.1_Intron|CXCR6_ENST00000438735.1_Silent_p.Q225Q|CXCR6_ENST00000457814.1_Silent_p.Q225Q|FYCO1_ENST00000296137.2_Intron|CXCR6_ENST00000304552.4_Silent_p.Q225Q|FYCO1_ENST00000535325.1_Intron			O00574	CXCR6_HUMAN	chemokine (C-X-C motif) receptor 6	225					viral genome replication	integral to plasma membrane	coreceptor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|lung(1)|prostate(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GAGGCTTCCAGAAGCACAGAT	0.498000													25	85					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74092231	74092231	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74092231G>A	ENST00000443185.2	-	4	2156	c.1839C>T	c.(1837-1839)tcC>tcT	p.S613S	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	613					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		TCACCTCTTCGGAAAAGCAGC	0.557000													20	46					0	0	1	0	0
DAND5	199699	broad.mit.edu	37	19	13084208	13084208	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13084208C>T	ENST00000317060.2	+	2	509	c.330C>T	c.(328-330)ttC>ttT	p.F110F	DAND5_ENST00000585548.1_3'UTR	NM_152654.2	NP_689867.1	Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	110	CTCK.					extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			CCCAGGTGTTCTCCCGGCCCG	0.622000													19	81					0	0	1	0	0
RBM11	54033	broad.mit.edu	37	21	15599286	15599286	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:15599286C>T	ENST00000400577.3	+	5	527	c.518C>T	c.(517-519)tCa>tTa	p.S173L	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	173							nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GTGTCTTCCTCACTGAATCAT	0.453000													33	269					0	0	1	0	0
HPCAL4	51440	broad.mit.edu	37	1	40149780	40149780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40149780G>A	ENST00000372844.3	-	3	598	c.207C>T	c.(205-207)ttC>ttT	p.F69F		NM_016257.2	NP_057341.1	Q9UM19	HPCL4_HUMAN	hippocalcin like 4	69	EF-hand 2.				central nervous system development	intracellular	calcium ion binding			breast(1)|central_nervous_system(1)|lung(5)|stomach(1)	8	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CGAAGGTGCGGAAAGCGTGCT	0.677000													20	43					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56144898	56144898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:56144898C>T	ENST00000394555.2	-	4	854	c.419G>A	c.(418-420)cGg>cAg	p.R140Q	EFEMP1_ENST00000394554.1_Missense_Mutation_p.R140Q|EFEMP1_ENST00000355426.3_Missense_Mutation_p.R140Q|EFEMP1_ENST00000424836.2_Missense_Mutation_p.R82Q	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	140					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGGGTTCCGCCGGATGACAAA	0.582000													14	99					0	0	1	0	0
TRIM5	85363	broad.mit.edu	37	11	5687273	5687273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5687273G>A	ENST00000305836.5	-	6	1108	c.806C>T	c.(805-807)cCa>cTa	p.P269L	TRIM5_ENST00000396853.4_Missense_Mutation_p.P270L|TRIM5_ENST00000396855.3_Missense_Mutation_p.P269L|TRIM5_ENST00000396847.3_Missense_Mutation_p.P269L|TRIM5_ENST00000380027.1_Missense_Mutation_p.P269L|TRIM5_ENST00000380034.3_Missense_Mutation_p.P269L|TRIM5_ENST00000483835.1_5'UTR			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	269					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		TTGATTTTTTGGAAAAGTTTC	0.403000													30	90					0	0	1	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99338587	99338587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:99338587C>T	ENST00000408927.3	+	9	1090	c.977C>T	c.(976-978)cCa>cTa	p.P326L	RAP1GDS1_ENST00000453712.2_Missense_Mutation_p.P327L|RAP1GDS1_ENST00000339360.5_Missense_Mutation_p.P327L|RAP1GDS1_ENST00000264572.7_Missense_Mutation_p.P235L|RAP1GDS1_ENST00000408900.3_Missense_Mutation_p.P277L|RAP1GDS1_ENST00000380158.4_Missense_Mutation_p.P278L	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	326							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TCTTGGATCCCATCAAATAAC	0.388000			T	NUP98	T-ALL								20	51					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350363	51350363	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51350363C>T	ENST00000327536.5	-	3	693	c.594G>A	c.(592-594)aaG>aaA	p.K198K	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	198										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		GGTTCAGCTTCTTCCGGAACT	0.488000													13	107					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70346365	70346365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70346365C>T	ENST00000305107.6	-	6	1620	c.1574G>A	c.(1573-1575)gGg>gAg	p.G525E	UGT2B4_ENST00000381096.3_Missense_Mutation_p.G389E|UGT2B4_ENST00000512583.1_3'UTR|UGT2B4_ENST00000506580.1_5'UTR	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	525					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						ATCTCTTTTCCCCTTCTTTCC	0.408000													37	86					0	0	1	0	0
CLEC4M	10332	broad.mit.edu	37	19	7828164	7828164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7828164C>T	ENST00000327325.5	+	1	130	c.12C>T	c.(10-12)tcC>tcT	p.S4S	CLEC4M_ENST00000248228.4_Silent_p.S4S|CLEC4M_ENST00000595496.1_Silent_p.S4S|CLEC4M_ENST00000596707.1_Silent_p.S4S|CLEC4M_ENST00000334806.5_Silent_p.S4S|CLEC4M_ENST00000596363.1_Silent_p.S4S|CLEC4M_ENST00000597522.1_Silent_p.S4S|CLEC4M_ENST00000357361.2_Silent_p.S4S|CLEC4M_ENST00000394122.2_Silent_p.S4S|CLEC4M_ENST00000359059.5_Silent_p.S4S	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	4					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						TGAGTGACTCCAAGGAACCAA	0.547000													70	47					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430058	43430058	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43430058C>T	ENST00000446844.3	-	0	1199				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GCTGAAACTTCCCATTAATTG	0.458000													94	298					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389456	4389456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4389456C>T	ENST00000408920.2	-	1	160	c.70G>A	c.(70-72)Gac>Aac	p.D24N		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGTGCTGGTCCTGTAGGCCA	0.517000													19	22					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2711054	2711054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2711054C>T	ENST00000399655.1	+	22	3153	c.2888C>T	c.(2887-2889)tCt>tTt	p.S963F	CACNA1C_ENST00000399637.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000480911.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000335762.5_Missense_Mutation_p.S988F|CACNA1C_ENST00000399603.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399649.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399595.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399606.1_Missense_Mutation_p.S983F|CACNA1C_ENST00000399601.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399617.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000344100.3_Missense_Mutation_p.S963F|CACNA1C_ENST00000399621.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399629.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000327702.7_Missense_Mutation_p.S963F|CACNA1C_ENST00000406454.3_Missense_Mutation_p.S963F|CACNA1C_ENST00000402845.3_Missense_Mutation_p.S963F|CACNA1C_ENST00000399597.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000347598.4_Missense_Mutation_p.S983F|CACNA1C_ENST00000399641.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399638.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399644.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399591.1_Missense_Mutation_p.S963F|CACNA1C_ENST00000399634.1_Missense_Mutation_p.S963F	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	983					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity	p.S498Y(1)|p.S963Y(1)|p.S1013Y(1)		NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CACAAGGGTTCTTTCTGCCGG	0.577000													17	42					0	0	1	0	0
IGLV3-27	28791	broad.mit.edu	37	22	23011177	23011177	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23011177C>T	ENST00000390304.2	+	0	278																											CTGAGCGATTCTCCGGCTCCA	0.557000													17	37					0	0	1	0	0
TNFRSF9	3604	broad.mit.edu	37	1	7995115	7995115	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:7995115C>T	ENST00000377507.3	-	6	668	c.502G>A	c.(502-504)Gga>Aga	p.G168R		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	168					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGATGCTCCCGGAGAGAGG	0.542000													13	65					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5282896	5282896	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5282896G>A	ENST00000546004.1	-	3	1191	c.945C>T	c.(943-945)ttC>ttT	p.F315F	PROKR2_ENST00000217270.3_Silent_p.F315F			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	315						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CGACCACGTAGAAGGCAGTGA	0.517000										HNSCC(71;0.22)			15	132					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62729720	62729720	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62729720C>T	ENST00000349451.3	+	6	1093	c.681C>T	c.(679-681)ccC>ccT	p.P227P	OPRL1_ENST00000336866.2_Silent_p.P227P|OPRL1_ENST00000355631.4_Silent_p.P227P	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	227					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TCATCGTCCCCGTGCTCGTCA	0.622000													58	116					0	0	1	0	0
TESC	54997	broad.mit.edu	37	12	117479781	117479781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117479781C>T	ENST00000335209.7	-	7	724	c.538G>A	c.(538-540)Gag>Aag	p.E180K	TESC_ENST00000392545.4_Missense_Mutation_p.E233K|TESC_ENST00000541210.1_Missense_Mutation_p.E153K			Q96BS2	TESC_HUMAN	tescalcin	180					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		GTGATCCCCTCGTACACCTGA	0.667000													4	8					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808333	48808333	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48808333G>A	ENST00000309835.3	+	1	571	c.561G>A	c.(559-561)tgG>tgA	p.W187*	STON1_ENST00000404752.1_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000402114.2_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000394751.3_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000394754.1_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000309827.2_Nonsense_Mutation_p.W187*|STON1_ENST00000406226.1_Nonsense_Mutation_p.W187*|STON1-GTF2A1L_ENST00000405008.1_Nonsense_Mutation_p.W187*					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTCCATTTTGGAAAGATGAAG	0.428000													7	87					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907015	77907015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77907015C>T	ENST00000355300.6	-	2	1408	c.1234G>A	c.(1234-1236)Gat>Aat	p.D412N	LINGO1_ENST00000561030.1_Missense_Mutation_p.D406N	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	412	Ig-like C2-type.|LRRCT.				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						AGTAGCACATCAGGGAAGTCC	0.652000													4	32					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31154973	31154973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31154973G>A	ENST00000349752.5	-	10	1658	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	GALNT14_ENST00000420311.2_Missense_Mutation_p.P305L|GALNT14_ENST00000406653.1_Missense_Mutation_p.P320L|GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000356174.3_Missense_Mutation_p.P307L|GALNT14_ENST00000324589.5_Missense_Mutation_p.P345L	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	340						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					GAAAACGTAGGGGTGCTTCTT	0.602000													31	71					0	0	1	0	0
AMIGO1	57463	broad.mit.edu	37	1	110051073	110051073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110051073G>A	ENST00000369864.4	-	2	811	c.462C>T	c.(460-462)ttC>ttT	p.F154F	AMIGO1_ENST00000369862.1_Silent_p.F154F			Q86WK6	AMGO1_HUMAN	adhesion molecule with Ig-like domain 1	154					axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		CCATGTCATCGAAGGCGCACC	0.537000													36	109					0	0	1	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215667	20215667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20215667C>T	ENST00000331723.1	+	1	81	c.81C>T	c.(79-81)ctC>ctT	p.L27L		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCTATTTCTCTTCTTACTAT	0.393000													54	114					0	0	1	0	0
SYNJ2BP	55333	broad.mit.edu	37	14	70842434	70842434	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70842434G>A	ENST00000256366.4	-	3	337	c.256C>T	c.(256-258)Cgt>Tgt	p.R86C	SYNJ2BP_ENST00000554216.1_5'UTR|RP11-718G2.3_ENST00000555276.1_RNA	NM_018373.2	NP_060843.2			synaptojanin 2 binding protein											central_nervous_system(1)|kidney(2)|large_intestine(1)|upper_aerodigestive_tract(1)	5				all cancers(60;0.00367)|BRCA - Breast invasive adenocarcinoma(234;0.00716)|OV - Ovarian serous cystadenocarcinoma(108;0.0377)		CCTGCATTACGAAAGAGGTCT	0.463000													52	133					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2820136	2820136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2820136G>A	ENST00000520002.1	-	62	10038	c.9483C>T	c.(9481-9483)atC>atT	p.I3161I	CSMD1_ENST00000542608.1_Silent_p.I2983I|CSMD1_ENST00000537824.1_Silent_p.I3160I|CSMD1_ENST00000602723.1_Silent_p.I2984I|CSMD1_ENST00000400186.3_Silent_p.I2984I|CSMD1_ENST00000602557.1_Silent_p.I3161I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3161	Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTTCTGCGGGGATGCCAGGGT	0.493000													12	11					0	0	1	0	0
SNCB	6620	broad.mit.edu	37	5	176056599	176056599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176056599C>T	ENST00000310112.3	-	3	307	c.57G>A	c.(55-57)gcG>gcA	p.A19A	SNCB_ENST00000510387.1_Silent_p.A19A|SNCB_ENST00000393693.2_Silent_p.A19A|SNCB_ENST00000506696.1_Silent_p.A19A	NM_001001502.1	NP_001001502.1	Q16143	SYUB_HUMAN	synuclein, beta	19							calcium ion binding|phospholipase inhibitor activity			breast(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	10	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGTTTTCTCCGCGGCTGCCA	0.672000													11	29					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	36943516	36943516	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:36943516G>A	ENST00000379242.3	+	2	305	c.3G>A	c.(1-3)atG>atA	p.M1I	VIT_ENST00000379241.3_Start_Codon_SNP_p.M1I|VIT_ENST00000404084.1_Start_Codon_SNP_p.M1I|VIT_ENST00000389975.3_Start_Codon_SNP_p.M1I|VIT_ENST00000457137.2_Start_Codon_SNP_p.M1I|VIT_ENST00000497382.1_5'UTR|VIT_ENST00000401530.1_Start_Codon_SNP_p.M1I	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	1						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				TGATATTTATGAGGACTGTTG	0.383000													20	65					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121498457	121498457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121498457C>T	ENST00000260197.7	+	47	6687	c.6558C>T	c.(6556-6558)ttC>ttT	p.F2186F	SORL1_ENST00000534286.1_Silent_p.F1096F|SORL1_ENST00000525532.1_Silent_p.F1130F|SORL1_ENST00000532694.1_Silent_p.F1032F|SORL1_ENST00000527934.1_Silent_p.F801F	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2186					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CCGCAATCTTCTCCTCTGGGG	0.607000													7	38					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99367785	99367785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99367785G>A	ENST00000336411.2	-	5	575	c.392C>T	c.(391-393)tCa>tTa	p.S131L	CYP3A4_ENST00000354593.2_Intron	NM_001202855.2|NM_017460.5	NP_001189784.1|NP_059488.2	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	131					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	AGACAGCAATGATCGTAATCT	0.388000													37	101					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121393311	121393311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121393311C>T	ENST00000260197.7	+	10	1550	c.1421C>T	c.(1420-1422)tCc>tTc	p.S474F	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	474					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CAGGGCTGTTCCCTTCATCTG	0.572000													52	172					0	0	1	0	0
DKK1	22943	broad.mit.edu	37	10	54074332	54074332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:54074332C>T	ENST00000373970.3	+	1	277	c.138C>T	c.(136-138)ccC>ccT	p.P46P		NM_012242.2	NP_036374.1	O94907	DKK1_HUMAN	dickkopf WNT signaling pathway inhibitor 1	46					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			kidney(2)|large_intestine(4)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	16						AGAACCTGCCCCCACCGCTGG	0.647000											OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	95					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68956332	68956332	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68956332G>A	ENST00000356291.2	-	3	250	c.191C>T	c.(190-192)tCt>tTt	p.S64F		NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	64	SEA.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						GACTTTAAAAGAGGCAAGGTA	0.328000													6	117					0	0	1	0	0
ZNF503	84858	broad.mit.edu	37	10	77159218	77159218	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:77159218G>A	ENST00000372524.4	-	2	1716	c.1230C>T	c.(1228-1230)tcC>tcT	p.S410S	ZNF503_ENST00000535216.1_Silent_p.S410S|RP11-399K21.11_ENST00000418818.2_lincRNA	NM_032772.4	NP_116161.2	Q96F45	ZN503_HUMAN	zinc finger protein 503	410	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			lung(4)|ovary(1)|skin(1)	6	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					CCAAAGGGCTGGAGCCGGCCG	0.716000													4	4					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38237701	38237701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38237701G>A	ENST00000379705.3	-	6	2397	c.1540C>T	c.(1540-1542)Ctg>Ttg	p.L514L	TRPC4_ENST00000494529.1_5'UTR|TRPC4_ENST00000358477.2_Silent_p.L514L|TRPC4_ENST00000447043.1_Silent_p.L514L|TRPC4_ENST00000379673.2_Silent_p.L514L|TRPC4_ENST00000338947.5_Silent_p.L341L|TRPC4_ENST00000355779.2_Silent_p.L514L|TRPC4_ENST00000379679.1_Silent_p.L341L|TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000379681.3_Silent_p.L514L			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	514					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AAAATGTCCAGGAGCATTCTT	0.388000													23	63					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72889564	72889564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:72889564G>A	ENST00000264839.7	+	5	758	c.758G>A	c.(757-759)gGg>gAg	p.G253E	RIMS1_ENST00000348717.5_Missense_Mutation_p.G253E|RIMS1_ENST00000517960.1_Missense_Mutation_p.G253E|RIMS1_ENST00000491071.2_Missense_Mutation_p.G253E|RIMS1_ENST00000522291.1_Missense_Mutation_p.G253E|RIMS1_ENST00000521978.1_Missense_Mutation_p.G253E|RIMS1_ENST00000520567.1_Missense_Mutation_p.G253E|RIMS1_ENST00000518273.1_Missense_Mutation_p.G253E			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	253					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAAGCCTTGGGGCCTGAACAG	0.557000													10	18					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94069757	94069757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94069757C>T	ENST00000553484.1	+	26	3901	c.3747C>T	c.(3745-3747)tcC>tcT	p.S1249S	UNC79_ENST00000555664.1_Silent_p.S1249S|UNC79_ENST00000393151.2_Silent_p.S1249S|UNC79_ENST00000256339.4_Silent_p.S1072S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1249						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCCTGACCTCCAAAATTCGTT	0.478000													10	45					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102964006	102964006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102964006C>T	ENST00000359520.7	+	19	4257	c.4031C>T	c.(4030-4032)cCc>cTc	p.P1344L		NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1344							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						GACAAGAACCCCGCCGGGGAC	0.672000													6	19					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205549071	205549071	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205549071C>T	ENST00000367147.4	+	2	516	c.423C>T	c.(421-423)ttC>ttT	p.F141F	MFSD4_ENST00000539267.1_Silent_p.F141F|MFSD4_ENST00000536357.1_Silent_p.F141F	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	141					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CGGCCGTCTTCCTCCAGGTAA	0.672000													12	35					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23851691	23851691	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23851691G>A	ENST00000405093.3	-	38	5812	c.5742C>T	c.(5740-5742)atC>atT	p.I1914I	MYH6_ENST00000356287.3_Silent_p.I1914I	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1914					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle	p.I1914I(1)		breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GGGACTCAGCGATGTCCGCCC	0.592000													42	96					0	0	1	0	0
MAPK15	225689	broad.mit.edu	37	8	144800391	144800391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144800391G>A	ENST00000338033.4	+	4	324	c.205G>A	c.(205-207)Gac>Aac	p.D69N	MAPK15_ENST00000395108.2_Missense_Mutation_p.D69N|MAPK15_ENST00000395107.4_Missense_Mutation_p.D69N	NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	69	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGAGTTTGGGGACCATCCCAA	0.592000													20	47					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14160099	14160099	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14160099G>A	ENST00000263379.2	+	10	1500	c.1375G>A	c.(1375-1377)Gga>Aga	p.G459R		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	459	Fibronectin type-III 3.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						TGCACAGAGTGGAACCAGCCC	0.642000													7	81					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183191281	183191281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183191281C>T	ENST00000264144.4	+	6	763	c.698C>T	c.(697-699)tCa>tTa	p.S233L	LAMC2_ENST00000493293.1_Missense_Mutation_p.S233L	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	233	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						CTCCAATGGTCACAGCGCCAT	0.488000													34	115					0	0	1	0	0
URM1	81605	broad.mit.edu	37	9	131151740	131151740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131151740C>T	ENST00000452446.1	+	4	451	c.389C>T	c.(388-390)cCa>cTa	p.P130L	URM1_ENST00000372853.4_Intron|URM1_ENST00000483206.1_3'UTR|URM1_ENST00000372850.1_3'UTR	NM_001135947.2	NP_001129419.1	Q9BTM9	URM1_HUMAN	ubiquitin related modifier 1	0					tRNA thio-modification|tRNA wobble uridine modification		protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)	5						TCTCCCACTCCAGGTGAGGAA	0.562000													7	5					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003933	122003933	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122003933G>A	ENST00000498619.1	+	7	3600	c.3162G>A	c.(3160-3162)gtG>gtA	p.V1054V	CASR_ENST00000296154.5_Silent_p.V1044V|CASR_ENST00000490131.1_Silent_p.V1044V	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	1044					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GGCCAGAGGTGGAGGACCCTG	0.547000													27	92					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7571715	7571715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7571715G>A	ENST00000379802.3	+	14	2142	c.1801G>A	c.(1801-1803)Gga>Aga	p.G601R	DSP_ENST00000418664.2_Missense_Mutation_p.G601R	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	601	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGAGATGTTTGGAGATGATGA	0.483000													28	216					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75406808	75406808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75406808G>A	ENST00000394810.2	-	4	2751	c.2602C>T	c.(2602-2604)Ccc>Tcc	p.P868S	SYNPO2L_ENST00000372873.4_Missense_Mutation_p.P644S|SYNPO2L_ENST00000372872.4_Intron	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	868	Pro-rich.					cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					GGAGTCGGGGGAACCTCATCA	0.582000													50	134					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27857437	27857437	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:27857437C>T	ENST00000261716.3	+	18	2680	c.2161C>T	c.(2161-2163)Caa>Taa	p.Q721*	TAOK1_ENST00000536202.1_Nonsense_Mutation_p.Q573*	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	721					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			TAAAGAACTCCAAATAAAAAA	0.353000													12	13					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183211937	183211937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183211937C>T	ENST00000341319.3	-	5	1315	c.1280G>A	c.(1279-1281)gGa>gAa	p.G427E		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	427										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GTCAAAGCCTCCGATCACATA	0.458000													41	139					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55183954	55183954	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:55183954C>T	ENST00000337714.3	+	2	1362	c.1129C>T	c.(1129-1131)Cag>Tag	p.Q377*	AKAP1_ENST00000539273.1_Nonsense_Mutation_p.Q377*|AKAP1_ENST00000572557.1_Nonsense_Mutation_p.Q377*|AKAP1_ENST00000571629.1_Nonsense_Mutation_p.Q377*|AKAP1_ENST00000314126.3_Nonsense_Mutation_p.Q377*	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	377					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					TCGTGTGTGTCAGGCCAGTCA	0.577000													16	94					0	0	1	0	0
CASQ2	845	broad.mit.edu	37	1	116311118	116311118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:116311118G>A	ENST00000261448.5	-	1	284	c.45C>T	c.(43-45)tcC>tcT	p.S15S	CASQ2_ENST00000456138.2_Silent_p.S15S	NM_001232.3	NP_001223.2	O14958	CASQ2_HUMAN	calsequestrin 2 (cardiac muscle)	15					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	18	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CCCTGCAAGAGGACAGAAAAT	0.418000													18	37					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160274736	160274736	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:160274736C>T	ENST00000264431.4	+	22	4125	c.3706C>T	c.(3706-3708)Cgc>Tgc	p.R1236C		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1236					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TCAGGGGGATCGCGCGTCACT	0.532000													29	107					0	0	1	0	0
AP4E1	23431	broad.mit.edu	37	15	51294740	51294740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51294740C>T	ENST00000261842.5	+	21	3401	c.3295C>T	c.(3295-3297)Ccc>Tcc	p.P1099S	AP4E1_ENST00000561397.1_3'UTR|AP4E1_ENST00000560508.1_Missense_Mutation_p.P1024S	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	1099					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		CCCATCCATCCCCTGCTTACT	0.413000													59	155					0	0	1	0	0
GPR39	2863	broad.mit.edu	37	2	133175158	133175158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133175158G>A	ENST00000329321.3	+	1	1012	c.543G>A	c.(541-543)gtG>gtA	p.V181V		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	181						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding	p.V181V(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ACCCCCTGGTGAACGTGCCCA	0.617000													19	62					0	0	1	0	0
DPPA3P2	400206	broad.mit.edu	37	14	36840769	36840769	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:36840769G>A	ENST00000557188.1	+	0	400																											CGCTAGTAGCGAATCTGTTTC	0.502000													14	26					0	0	1	0	0
ART1	417	broad.mit.edu	37	11	3681174	3681174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3681174G>A	ENST00000250693.1	+	3	526	c.425G>A	c.(424-426)cGg>cAg	p.R142Q		NM_004314.2	NP_004305.2	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1	142					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			endometrium(1)|large_intestine(2)|liver(1)|lung(3)|skin(1)	8		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	GGCCGCTCCCGGGCCCACTAC	0.667000													26	49					0	0	1	0	0
PLIN5	440503	broad.mit.edu	37	19	4525644	4525644	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4525644C>T	ENST00000381848.3	-	6	801		c.e6+1			NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5							lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CGGGCTCTCACCAGCTCCAGC	0.637000													12	50					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43250649	43250649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43250649C>T	ENST00000259750.4	+	14	2254	c.2171C>T	c.(2170-2172)cCt>cTt	p.P724L		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	724						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCACTGGCTCCTGTTCAGCCT	0.587000													28	40					0	0	1	0	0
TRIM6	117854	broad.mit.edu	37	11	5626743	5626743	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5626743G>A	ENST00000380097.3	+	4	1022	c.780G>A	c.(778-780)gaG>gaA	p.E260E	TRIM6_ENST00000506134.1_Silent_p.E57E|TRIM6-TRIM34_ENST00000354852.5_Silent_p.E260E|TRIM6_ENST00000445329.1_Silent_p.E57E|TRIM6_ENST00000380107.1_Silent_p.E206E|TRIM6_ENST00000278302.5_Silent_p.E232E|TRIM6_ENST00000515022.1_Silent_p.E57E|HBG2_ENST00000380259.2_Intron|TRIM6_ENST00000507320.1_Silent_p.E57E|AC015691.13_ENST00000394793.2_RNA	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		CGCTGCGAGAGCTCATCTCGG	0.522000											OREG0003723	type=REGULATORY REGION|Gene=TRIM6|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	13	48					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984756	85984756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85984756G>A	ENST00000372113.4	-	2	230	c.225C>T	c.(223-225)ttC>ttT	p.F75F	LRIT2_ENST00000538192.1_Silent_p.F75F	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	75						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						TCATGTTGATGAAAGACCCTT	0.463000													13	114					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27949610	27949610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27949610C>T	ENST00000374005.3	-	4	560	c.272G>A	c.(271-273)cGa>cAa	p.R91Q	FGR_ENST00000399173.1_Missense_Mutation_p.R91Q|FGR_ENST00000374004.1_Missense_Mutation_p.R91Q|FGR_ENST00000545953.1_Missense_Mutation_p.R91Q	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	91	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ATCCTCAGTTCGAGCCTCATA	0.562000													12	36					0	0	1	0	0
ANKK1	255239	broad.mit.edu	37	11	113270348	113270348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113270348C>T	ENST00000303941.3	+	8	1751	c.1657C>T	c.(1657-1659)Cct>Tct	p.P553S		NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	553							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|stomach(1)	29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		TGGAGCGGTCCCTGATGCCCT	0.597000													6	8					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38802870	38802870	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38802870C>T	ENST00000449082.2	-	6	695	c.696G>A	c.(694-696)ctG>ctA	p.L232L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	232					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAATGACCTTCAGGCCTGCGG	0.512000													11	37					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113547238	113547238	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113547238C>T	ENST00000416899.2	+	10	1630	c.1504C>T	c.(1504-1506)Ctt>Ttt	p.L502F	MUSK_ENST00000189978.5_Missense_Mutation_p.L510F|MUSK_ENST00000374438.1_Intron|MUSK_ENST00000374448.4_Missense_Mutation_p.L510F			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	510					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						ATTTGTGCTTCTTACCATAAC	0.373000													40	123					0	0	1	0	0
ACTA1	58	broad.mit.edu	37	1	229568311	229568311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:229568311C>T	ENST00000366684.3	-	3	548	c.446G>A	c.(445-447)aGg>aAg	p.R149K	ACTA1_ENST00000366683.2_Intron	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	149					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	ACCGGTGGTCCTGCCGGAGGC	0.711000													20	48					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96264406	96264406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:96264406C>T	ENST00000347108.3	-	9	1631	c.1199G>A	c.(1198-1200)cGa>cAa	p.R400Q	DZIP1_ENST00000361396.2_Missense_Mutation_p.R400Q|DZIP1_ENST00000376829.2_Missense_Mutation_p.R400Q|DZIP1_ENST00000361156.3_Missense_Mutation_p.R400Q			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	400					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			cattgAGGTTCGAAGTTTCTC	0.378000													25	71					0	0	1	0	0
SSTR2	6752	broad.mit.edu	37	17	71166148	71166148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:71166148C>T	ENST00000357585.2	+	2	1059	c.690C>T	c.(688-690)ttC>ttT	p.F230F	RP11-143K11.5_ENST00000580671.1_RNA|SSTR2_ENST00000315332.2_Silent_p.F230F	NM_001050.2	NP_001041.1	P30874	SSR2_HUMAN	somatostatin receptor 2	230					digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity			endometrium(2)|large_intestine(5)|lung(2)|prostate(2)	11			LUSC - Lung squamous cell carcinoma(166;0.197)			GCTACCTGTTCATTATCATCA	0.512000													38	139					0	0	1	0	0
MRPL49	740	broad.mit.edu	37	11	64893018	64893018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64893018C>T	ENST00000534078.1	+	2	173	c.137C>T	c.(136-138)tCt>tTt	p.S46F	MRPL49_ENST00000524482.1_3'UTR|MRPL49_ENST00000279242.2_Silent_p.V96V|MRPL49_ENST00000531705.1_Intron|MRPL49_ENST00000526171.1_Silent_p.V96V			Q13405	RM49_HUMAN	mitochondrial ribosomal protein L49	0					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			endometrium(1)|ovary(1)	2						ACATCCCCGTCTACAAGGACA	0.552000													23	82					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943464	72943464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72943464G>A	ENST00000328801.4	+	6	1514	c.1514G>A	c.(1513-1515)gGc>gAc	p.G505D		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	505						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CTGGGCCAGGGCCTGCAGCGG	0.642000													17	42					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5238990	5238990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5238990G>A	ENST00000372412.4	-	13	2025	c.1792C>T	c.(1792-1794)Cgc>Tgc	p.R598C	PTPRS_ENST00000348075.2_Missense_Mutation_p.R584C|PTPRS_ENST00000587303.1_Missense_Mutation_p.R597C|PTPRS_ENST00000588012.1_Missense_Mutation_p.R584C|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000353284.2_Missense_Mutation_p.R584C|PTPRS_ENST00000262963.6_Missense_Mutation_p.R593C|PTPRS_ENST00000592099.1_Missense_Mutation_p.R584C|PTPRS_ENST00000357368.4_Missense_Mutation_p.R597C			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	597	Fibronectin type-III 3.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TGCGGCGAGCGGGCCGCCAGG	0.711000													19	61					0	0	1	0	0
TRBV24-1	28563	broad.mit.edu	37	7	142364233	142364233	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142364233C>T	ENST00000390397.2	+	0	36																											CTCTTCATGCCATGGCCTCCC	0.493000													5	20					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93170762	93170762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93170762G>A	ENST00000298050.3	+	14	1792	c.1692G>A	c.(1690-1692)ctG>ctA	p.L564L	CCDC67_ENST00000525646.1_Silent_p.L306L	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	564										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				ATTTCCTTCTGGAAGAAGAGA	0.378000													20	42					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113694393	113694393	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113694393C>T	ENST00000003302.4	-	12	1285	c.1217G>A	c.(1216-1218)cGa>cAa	p.R406Q	USP28_ENST00000260188.5_Missense_Mutation_p.R406Q|USP28_ENST00000544967.1_Missense_Mutation_p.R114Q|USP28_ENST00000545540.1_Missense_Mutation_p.R281Q|USP28_ENST00000537706.1_Missense_Mutation_p.R406Q	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	406					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCTCTTATTTCGAATAAGCTC	0.318000													17	67					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54802110	54802110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54802110C>T	ENST00000391745.1	-	10	1445	c.1129G>A	c.(1129-1131)Gag>Aag	p.E377K	LILRA3_ENST00000391744.3_Missense_Mutation_p.E296K|LILRA3_ENST00000251390.3_Missense_Mutation_p.E360K					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCTGCCCCCTCCTTGGTCAAA	0.597000													41	124					0	0	1	0	0
IGHV3-43	28426	broad.mit.edu	37	14	106926359	106926359	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106926359C>T	ENST00000434710.1	-	0	262																											CCAGACCCTTCCCCGGAGCTT	0.542000													72	153					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26273425	26273425	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:26273425G>A	ENST00000381655.2	+	25	2468	c.2326G>A	c.(2326-2328)Gaa>Aaa	p.E776K	ATP8A2_ENST00000255283.8_Missense_Mutation_p.E736K|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	736					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GCTCTCCTTCGAAGTCCGGAG	0.542000													8	46					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122811931	122811931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122811931G>A	ENST00000194130.2	-	3	295	c.256C>T	c.(256-258)Cac>Tac	p.H86Y	SLC13A1_ENST00000539873.1_Missense_Mutation_p.H22Y	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	86						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	AGCAGTAAGTGAAAATCCTTG	0.338000													26	79					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841810	13841810	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13841810G>A	ENST00000265104.4	-	33	5579	c.5475C>T	c.(5473-5475)ttC>ttT	p.F1825F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1825	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCTGAGCAGGGAAGGATGAAA	0.358000									Kartagener syndrome				29	57					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73100164	73100164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73100164C>T	ENST00000450736.2	+	5	1668	c.1253C>T	c.(1252-1254)gCc>gTc	p.A418V	SLC16A5_ENST00000538213.2_Missense_Mutation_p.A458V|SLC16A5_ENST00000329783.4_Missense_Mutation_p.A418V|SLC16A5_ENST00000580123.1_Missense_Mutation_p.A418V			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	418					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	AGCTTCTACGCCCTGCAGAAG	0.567000													18	108					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292806	4292806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4292806C>T	ENST00000301272.2	-	5	684	c.639G>A	c.(637-639)ggG>ggA	p.G213G	TMIGD2_ENST00000600114.1_Silent_p.G93G|TMIGD2_ENST00000600349.1_Silent_p.G41G|TMIGD2_ENST00000595645.1_Silent_p.G209G	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2	213						integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGGTCCTTCCCCTCTCCAG	0.622000													8	105					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54849620	54849620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:54849620C>T	ENST00000333896.5	+	8	1406	c.1021C>T	c.(1021-1023)Ccc>Tcc	p.P341S	SPTBN1_ENST00000356805.4_Missense_Mutation_p.P354S	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	354					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GGAGAAACCACCCAAGTAAGA	0.413000													8	110					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915457	46915457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46915457C>T	ENST00000307522.3	-	1	1384	c.611G>A	c.(610-612)gGg>gAg	p.G204E		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	204						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CTTCAGCTTCCCCCAGGACAC	0.692000													14	20					0	0	1	0	0
HTR7P1	93164	broad.mit.edu	37	12	13155411	13155411	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13155411C>T	ENST00000543321.1	+	0	31				HTR7P1_ENST00000535469.1_RNA																							GCAGCGACTACCTTGGGGATC	0.527000													6	17					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64815823	64815823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64815823C>T	ENST00000358658.3	-	9	1260	c.1233G>A	c.(1231-1233)gcG>gcA	p.A411A	NAALADL1_ENST00000339885.2_Silent_p.A411A|NAALADL1_ENST00000528884.1_5'UTR|NAALADL1_ENST00000356632.3_Silent_p.A376A|NAALADL1_ENST00000340252.4_Silent_p.A462A|NAALADL1_ENST00000355721.3_Silent_p.A370A|NAALADL1_ENST00000526799.1_5'UTR|NAALADL1_ENST00000355369.2_Silent_p.A411A	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	411	NAALADase.				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						CCCCCCAGCTCGCAAACACGA	0.582000													9	99					0	0	1	0	0
XCR1	2829	broad.mit.edu	37	3	46062465	46062465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46062465G>A	ENST00000309285.3	-	2	1331	c.975C>T	c.(973-975)ttC>ttT	p.F325F	XCR1_ENST00000542109.1_Silent_p.F325F	NM_001024644.1	NP_001019815.1	P46094	XCR1_HUMAN	chemokine (C motif) receptor 1	325					chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CCTCATAGGCGAAGGCACCAG	0.647000													5	10					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75156789	75156789	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:75156789G>A	ENST00000342232.4	-	4	1920	c.1880C>T	c.(1879-1881)cCt>cTt	p.P627L	JPH1_ENST00000518195.1_5'UTR	NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	627					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			TTCCAAAGCAGGGCATGAATC	0.433000													30	169					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240256102	240256102	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240256102G>A	ENST00000319653.9	+	1	923	c.693G>A	c.(691-693)gaG>gaA	p.E231E		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	231					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCGCCGAGGAGCCTGCAGCGC	0.736000													5	14					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216784	21216784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21216784G>A	ENST00000380216.1	-	1	526	c.521C>T	c.(520-522)tCc>tTc	p.S174F		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	174					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AAAAGAGAAGGATCTCATGAT	0.383000													144	244					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129096476	129096476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129096476C>T	ENST00000249344.2	+	9	1071	c.1031C>T	c.(1030-1032)tCt>tTt	p.S344F	STRIP2_ENST00000435494.2_Missense_Mutation_p.S344F	NM_020704.2	NP_065755.1			striatin interacting protein 2																		CGCCGTGGCTCTCGAAGGGTA	0.552000													14	27					0	0	1	0	0
UBE2D3	7323	broad.mit.edu	37	4	103730987	103730987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:103730987G>A	ENST00000453744.2	-	3	563	c.50C>T	c.(49-51)cCt>cTt	p.P17L	UBE2D3_ENST00000394801.4_Missense_Mutation_p.P17L|UBE2D3_ENST00000394803.5_Missense_Mutation_p.P17L|UBE2D3_ENST00000504211.1_5'UTR|UBE2D3_ENST00000349311.8_Missense_Mutation_p.P17L|UBE2D3_ENST00000502404.1_5'UTR|UBE2D3_ENST00000505207.1_5'UTR|UBE2D3_ENST00000350435.7_Missense_Mutation_p.P11L|UBE2D3_ENST00000513098.1_5'UTR|UBE2D3_ENST00000357194.6_Missense_Mutation_p.P19L|UBE2D3_ENST00000321805.7_Missense_Mutation_p.P17L|UBE2D3_ENST00000338145.3_Missense_Mutation_p.P17L|UBE2D3_ENST00000394804.2_Missense_Mutation_p.P17L|UBE2D3_ENST00000343106.5_Missense_Mutation_p.P17L|UBE2D3_ENST00000507845.1_5'UTR	NM_181891.1	NP_871620.1	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3	17					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity			kidney(1)|lung(3)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		TTGTGCTGGAGGGTCACGGGC	0.383000													47	109					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20490535	20490535	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20490535G>A	ENST00000555186.1	+	0	515					NR_038836.1																						TGTTGGTAGTGGATCCAAAGG	0.428000													37	264					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129122724	129122724	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129122724C>T	ENST00000249344.2	+	20	2131	c.2091C>T	c.(2089-2091)gcC>gcT	p.A697A	STRIP2_ENST00000435494.2_Silent_p.A697A	NM_020704.2	NP_065755.1			striatin interacting protein 2																		TAAAGCGGGCCCTCAAGGTCA	0.443000													34	90					0	0	1	0	0
AHCYL2	23382	broad.mit.edu	37	7	128865045	128865045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128865045C>T	ENST00000325006.3	+	1	182	c.128C>T	c.(127-129)cCc>cTc	p.P43L	AHCYL2_ENST00000446544.2_Missense_Mutation_p.P43L	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	43					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						GCCATGGCCCCCCCGGCGGGC	0.786000													3	1					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987664	61987664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61987664G>A	ENST00000450719.3	-	3	284	c.47C>T	c.(46-48)tCc>tTc	p.S16F	CSHL1_ENST00000346606.6_Missense_Mutation_p.S16F|CSHL1_ENST00000561003.1_Missense_Mutation_p.S27F|CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000438387.2_Missense_Mutation_p.S27F|CSHL1_ENST00000259003.10_Missense_Mutation_p.S48F|CSHL1_ENST00000309894.5_Missense_Mutation_p.S110F			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	110						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						GAGCAGCAGGGAGATGTGGAG	0.627000													17	38					0	0	1	0	0
GET4	51608	broad.mit.edu	37	7	927046	927046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:927046C>T	ENST00000407192.1	+	3	2714	c.197C>T	c.(196-198)tCt>tTt	p.S66F	GET4_ENST00000265857.3_Missense_Mutation_p.S119F			Q7L5D6	GET4_HUMAN	golgi to ER traffic protein 4 homolog (S. cerevisiae)	119					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding			breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GACCCCAACTCTCCTGAGCGC	0.622000													37	95					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59166625	59166625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59166625C>T	ENST00000262717.4	+	3	851	c.453C>T	c.(451-453)ttC>ttT	p.F151F	CDH20_ENST00000536675.2_Silent_p.F151F|CDH20_ENST00000538374.1_Silent_p.F151F			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	151	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				AGTCAGAGTTCATCATCAAAA	0.537000													9	33					0	0	1	0	0
OR13C9	286362	broad.mit.edu	37	9	107380208	107380208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107380208G>A	ENST00000259362.1	-	1	277	c.278C>T	c.(277-279)tCc>tTc	p.S93F		NM_001001956.1	NP_001001956.1	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C, member 9	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(9)|prostate(1)|skin(4)	22						GCCAGAAAAGGAAATGGTCTT	0.502000													32	120					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90398133	90398133	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90398133C>T	ENST00000405460.2	+	87	18504	c.18408C>T	c.(18406-18408)ctC>ctT	p.L6136L	GPR98_ENST00000425867.2_Silent_p.L1797L	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6136					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGTTGGTTCTCTTTGTCATTT	0.373000											OREG0016703	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	14					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697782	6697782	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6697782C>T	ENST00000245907.6	-	20	2556	c.2464G>A	c.(2464-2466)Gag>Aag	p.E822K		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	822					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACTGTGACCTCGAAGGGGTCT	0.562000													5	40					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940498	144940498	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144940498G>A	ENST00000525985.1	-	2	6995	c.6924C>T	c.(6922-6924)acC>acT	p.T2308T				P58107	EPIPL_HUMAN	epiplakin 1	2308						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGTGTAGCCGGTGACGGCGC	0.706000													14	260					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60912783	60912783	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60912783G>A	ENST00000252999.3	-	16	2093	c.2026_splice	c.e16-1	p.P676_splice		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	676	Laminin EGF-like 7.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCAGTGGCAGGCTGCAGACAA	0.662000													12	38					0	0	1	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46106066	46106066	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46106066G>A	ENST00000355105.3	-	8	1920	c.560C>T	c.(559-561)cCt>cTt	p.P187L	GPBP1L1_ENST00000290795.3_Missense_Mutation_p.P187L	NM_021639.4	NP_067652.1	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding		GPBP1L1/MAST2_ENST00000361297(2)	breast(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|stomach(1)	21	Acute lymphoblastic leukemia(166;0.155)					CTTGGCACTAGGCGGGTTTTC	0.443000													59	144					0	0	1	0	0
SMTN	6525	broad.mit.edu	37	22	31487759	31487759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31487759C>T	ENST00000333137.7	+	11	1776	c.1558C>T	c.(1558-1560)Cgg>Tgg	p.R520W	SMTN_ENST00000347557.2_Missense_Mutation_p.R520W|SMTN_ENST00000358743.1_Missense_Mutation_p.R520W	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	520					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						GACCCTGGCTCGGCTGGGCAG	0.662000													14	17					0	0	1	0	0
TRIM35	23087	broad.mit.edu	37	8	27168522	27168522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27168522G>A	ENST00000305364.4	-	1	314	c.231C>T	c.(229-231)aaC>aaT	p.N77N	TRIM35_ENST00000521253.1_Silent_p.N77N	NM_171982.3	NP_741983.2	Q9UPQ4	TRI35_HUMAN	tripartite motif containing 35	77					apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding			breast(1)|endometrium(6)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	14		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		TCTCCACCAGGTTGTTGAGGG	0.697000													5	9					0	0	1	0	0
NXPE1	120400	broad.mit.edu	37	11	114392968	114392968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:114392968C>T	ENST00000536271.1	-	4	1757	c.514G>A	c.(514-516)Ggt>Agt	p.G172S	NXPE1_ENST00000424269.1_Missense_Mutation_p.G456S|NXPE1_ENST00000251921.2_Missense_Mutation_p.G314S					neurexophilin and PC-esterase domain family, member 1																		TTTTGAACACCGATGGCCCTG	0.438000													13	142					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43086883	43086883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43086883G>A	ENST00000267890.6	-	10	1047	c.939C>T	c.(937-939)acC>acT	p.T313T	TTBK2_ENST00000567840.1_Silent_p.T313T|TTBK2_ENST00000567274.1_Silent_p.T278T	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	313	Poly-Thr.		T -> A (in dbSNP:rs56017612).		cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		ACTGAGGGGTGGTAGAAGTAG	0.438000													9	134					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114111003	114111003	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:114111003G>A	ENST00000297405.5	-	5	1143	c.899C>T	c.(898-900)tCt>tTt	p.S300F	CSMD3_ENST00000352409.3_Missense_Mutation_p.S300F|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Missense_Mutation_p.S260F|CSMD3_ENST00000455883.2_Missense_Mutation_p.S300F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	300	CUB 2.					integral to membrane|plasma membrane		p.S300F(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGGTGGCTCAGAACCTTCTAT	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	43					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629474	47629474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:47629474G>A	ENST00000546455.1	+	4	1359	c.628G>A	c.(628-630)Gat>Aat	p.D210N	PCED1B_ENST00000432328.1_Missense_Mutation_p.D210N					PC-esterase domain containing 1B																		ACATAACTTCGATGTACTGGA	0.587000													9	15					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180383269	180383269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:180383269G>A	ENST00000410066.1	-	5	1096	c.493C>T	c.(493-495)Cgc>Tgc	p.R165C	ZNF385B_ENST00000336917.5_Missense_Mutation_p.R63C|ZNF385B_ENST00000409343.1_Missense_Mutation_p.R89C|ZNF385B_ENST00000409692.1_Missense_Mutation_p.R63C|ZNF385B_ENST00000466398.1_5'UTR	NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	165						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GAGTTAAAGCGAAGCTGACAG	0.353000													41	100					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219411757	219411757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219411757G>A	ENST00000258399.3	-	7	899	c.487C>T	c.(487-489)Ctt>Ttt	p.L163F	USP37_ENST00000454775.1_Missense_Mutation_p.L163F|USP37_ENST00000418019.1_Missense_Mutation_p.L163F|USP37_ENST00000338465.5_Missense_Mutation_p.L163F|USP37_ENST00000415516.1_Missense_Mutation_p.L91F	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	163					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		GGATTACCAAGAACTTTTCGA	0.368000													30	104					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	85775681	85775681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:85775681C>T	ENST00000383699.3	+	2	698	c.71C>T	c.(70-72)tCa>tTa	p.S24L	CADM2_ENST00000407528.2_Intron|CADM2_ENST00000405615.2_Missense_Mutation_p.S17L	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	20					adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GCGGCTGCTTCAAAGAATAAA	0.353000													20	177					0	0	1	0	0
CLEC4E	26253	broad.mit.edu	37	12	8692540	8692540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8692540C>T	ENST00000299663.3	-	2	206	c.41G>A	c.(40-42)aGa>aAa	p.R14K	CLEC4E_ENST00000545274.1_Missense_Mutation_p.R14K|CLEC4E_ENST00000446457.2_Missense_Mutation_p.R14K	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	14						integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					GAAGCATCCTCTCTCTGTAGA	0.408000													29	119					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585536	7585536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7585536G>A	ENST00000379802.3	+	24	8382	c.8041G>A	c.(8041-8043)Gac>Aac	p.D2681N	DSP_ENST00000418664.2_Missense_Mutation_p.D2082N	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2681	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGGTGTGATTGACCAAGACAT	0.567000													59	154					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10401959	10401959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10401959C>T	ENST00000226207.5	-	30	4259	c.4165G>A	c.(4165-4167)Gag>Aag	p.E1389K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1389						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TCCTCCAGCTCCTCTGTGCGC	0.478000													51	71					0	0	1	0	0
TTC39A	22996	broad.mit.edu	37	1	51754555	51754555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:51754555C>T	ENST00000447632.2	-	17	1722	c.1674G>A	c.(1672-1674)gaG>gaA	p.E558E	TTC39A_ENST00000262675.7_Silent_p.E495E|TTC39A_ENST00000451380.1_Silent_p.E522E|TTC39A_ENST00000530004.1_Silent_p.E166E|TTC39A_ENST00000534098.1_5'UTR|TTC39A_ENST00000371750.5_Silent_p.E523E|TTC39A_ENST00000413473.2_Silent_p.E526E			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	558							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						TTCTGTCTTGCTCCATAAGCA	0.493000													8	11					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142625942	142625942	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142625942G>A	ENST00000265310.1	-	6	954	c.606C>T	c.(604-606)atC>atT	p.I202I	TRPV5_ENST00000442623.1_Silent_p.I202I	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	202					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GGAGGATGAGGATGTGTAATA	0.562000													27	113					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247920864	247920864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247920864G>A	ENST00000408896.2	-	1	1118	c.845C>T	c.(844-846)gCt>gTt	p.A282V		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CAGCATCGGAGCCACCATTGA	0.473000													61	113					0	0	1	0	0
CDH3	1001	broad.mit.edu	37	16	68732150	68732150	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68732150G>T	ENST00000264012.4	+	16	2881	c.2337G>T	c.(2335-2337)gtG>gtT	p.V779V	CDH3_ENST00000581171.1_Silent_p.V724V|CDH3_ENST00000429102.2_3'UTR	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	779					adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CCCTCTTGGTGTTCGACTATG	0.622000													37	92					2.05212e-20	2.06501e-20	1	1	0
MYRF	745	broad.mit.edu	37	11	61533562	61533562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61533562C>T	ENST00000278836.5	+	3	363	c.267C>T	c.(265-267)ccC>ccT	p.P89P	MYRF_ENST00000265460.5_Silent_p.P80P	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		GCCATGGTCCCCTCCCACCCC	0.741000													7	30					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516978	140516978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140516978C>T	ENST00000231134.5	+	1	2179	c.1962C>T	c.(1960-1962)acC>acT	p.T654T		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		654	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCGGCCACCGCCACGCTGC	0.731000													18	119					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53854443	53854443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53854443C>T	ENST00000458035.1	+	4	632	c.515C>T	c.(514-516)tCg>tTg	p.S172L	ZNF845_ENST00000595091.1_Missense_Mutation_p.S172L	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AACAGTGCTTCGTTGGTTTCA	0.393000													44	115					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7581641	7581641	+	Missense_Mutation	SNP	G	G	A	rs142885240	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7581641G>A	ENST00000379802.3	+	23	5559	c.5218G>A	c.(5218-5220)Gaa>Aaa	p.E1740K	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1740	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton	p.E1740K(1)		biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGACGAAGCGAAGCGGACAG	0.507000													46	133					0	0	1	0	0
HDX	139324	broad.mit.edu	37	X	83588782	83588782	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:83588782A>C	ENST00000297977.5	-	8	1920	c.1809T>G	c.(1807-1809)tcT>tcG	p.S603S	HDX_ENST00000506585.2_Silent_p.S545S|HDX_ENST00000373177.2_Silent_p.S603S	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	603						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						AATCCAAGAAAGAGTTTACTT	0.249000													5	8					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12121044	12121044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:12121044C>T	ENST00000379388.2	+	4	1348	c.1016C>T	c.(1015-1017)cCt>cTt	p.P339L		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	339					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CTAACTTCACCTTCCAGTAGA	0.433000													65	143					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64570110	64570110	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64570110G>A	ENST00000294066.2	-	3	261	c.170C>T	c.(169-171)tCc>tTc	p.S57F	MAP4K2_ENST00000377350.3_Missense_Mutation_p.S57F|MAP4K2_ENST00000468062.1_5'UTR	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2	57	Protein kinase.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						CTGCTGGAGGGAGCTGATGTC	0.612000													4	28					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109672146	109672146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109672146C>T	ENST00000356711.2	+	23	2743	c.2617C>T	c.(2617-2619)Ctc>Ttc	p.L873F	MYO16_ENST00000457511.2_Missense_Mutation_p.L385F|MYO16_ENST00000251041.5_Missense_Mutation_p.L873F|MYO16_ENST00000357550.2_Missense_Mutation_p.L873F	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	873	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACTACAAAGTCTCCTAGAATC	0.423000													11	49					0	0	1	0	0
TBCEL	219899	broad.mit.edu	37	11	120925967	120925967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120925967C>T	ENST00000422003.2	+	5	850	c.662C>T	c.(661-663)tCa>tTa	p.S221L	TBCEL_ENST00000529397.1_Missense_Mutation_p.S221L	NM_152715.3	NP_689928.3	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	221						cytoplasm|cytoskeleton			TECTA/TBCEL(2)	endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		CCTGATGATTCATTGGCCAGG	0.433000													25	48					0	0	1	0	0
PDE4B	5142	broad.mit.edu	37	1	66829101	66829101	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:66829101C>T	ENST00000423207.2	+	10	1571	c.1086C>T	c.(1084-1086)ctC>ctT	p.L362L	PDE4B_ENST00000371045.5_Silent_p.L205L|PDE4B_ENST00000371049.3_Silent_p.L377L|PDE4B_ENST00000480109.2_Silent_p.L144L|PDE4B_ENST00000329654.4_Silent_p.L377L	NM_001037340.1	NP_001032417.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	377					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	AAAGAGACCTCCTAAAGACAT	0.353000													16	49					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6051600	6051600	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6051600C>T	ENST00000409021.3	-	15	2358		c.e15-1		JAKMIP1_ENST00000409371.3_Splice_Site	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1						protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CATTCACATCCTGGAAGAGAT	0.443000													9	21					0	0	1	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153274984	153274984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153274984G>A	ENST00000290722.1	-	5	681	c.629C>T	c.(628-630)gCt>gTt	p.A210V		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	210					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCTTGTGCCAGCGGTGTGGAT	0.488000													45	86					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100268	8100268	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:8100268G>A	ENST00000379328.3	+	3	810	c.241_splice	c.e3-1	p.G81_splice	GATA3_ENST00000346208.3_Splice_Site_p.G81_splice	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	81					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						TGCCCCACAGGGAGCCAGGTG	0.672000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						33	61					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123021952	123021952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123021952C>T	ENST00000462833.1	-	14	3886	c.2674G>A	c.(2674-2676)Gat>Aat	p.D892N	ADCY5_ENST00000491190.1_Missense_Mutation_p.D525N|ADCY5_ENST00000309879.5_Missense_Mutation_p.D542N	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	892					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CCCTGCTCATCGCCCAGGCTG	0.647000													19	40					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107407872	107407872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107407872C>T	ENST00000334504.7	-	40	4260	c.4027G>A	c.(4027-4029)Gac>Aac	p.D1343N	COL4A6_ENST00000372216.4_Missense_Mutation_p.D1344N|COL4A6_ENST00000545689.1_Missense_Mutation_p.D1319N|COL4A6_ENST00000538570.1_Intron|COL4A6_ENST00000394872.2_Missense_Mutation_p.D1344N	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1344	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						AATCCTGGGTCTCCAGGTGGC	0.597000									Alport syndrome with Diffuse Leiomyomatosis				62	43					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431918	56431918	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56431918G>A	ENST00000302969.2	+	1	781	c.757G>A	c.(757-759)Ggc>Agc	p.G253S		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						CCTCTTCTATGGCACAGTCAT	0.498000													8	104					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40411940	40411940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40411940C>T	ENST00000221347.6	-	7	3695	c.3688G>A	c.(3688-3690)Gga>Aga	p.G1230R		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1230	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTGCGGTCCGCAGCTGGAG	0.667000													20	51					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117665278	117665278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117665278C>T	ENST00000317775.6	-	23	4259	c.3574G>A	c.(3574-3576)Gaa>Aaa	p.E1192K	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.E1226K	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1192	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGGTGCACTTCATCAGGGTAC	0.622000													17	37					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91404546	91404546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:91404546G>A	ENST00000370440.1	-	3	2582	c.2365C>T	c.(2365-2367)Cct>Tct	p.P789S	ZNF644_ENST00000467231.1_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.P789S|ZNF644_ENST00000361321.5_Intron|ZNF644_ENST00000347275.5_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	789					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		GGCTTATGAGGGTCTGAAATA	0.358000													30	76					0	0	1	0	0
CCDC50	152137	broad.mit.edu	37	3	191107287	191107287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:191107287C>T	ENST00000392455.3	+	10	1395	c.797C>T	c.(796-798)cCa>cTa	p.P266L	CCDC50_ENST00000392456.3_Missense_Mutation_p.P442L	NM_174908.3	NP_777568.1	Q8IVM0	CCD50_HUMAN	coiled-coil domain containing 50	266	Poly-Pro.					cytoplasm	protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|stomach(1)	23	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		CCTTTTAGGCCACCACCACCT	0.418000													65	148					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37725472	37725472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37725472C>T	ENST00000264741.5	+	18	2289	c.2033C>T	c.(2032-2034)tCc>tTc	p.S678F		NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	678					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TTCAATGTTTCCCGGGAGCTC	0.473000													16	38					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81545644	81545644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81545644G>A	ENST00000548058.1	+	6	1853	c.943G>A	c.(943-945)Gga>Aga	p.G315R	ACSS3_ENST00000548324.1_5'UTR|ACSS3_ENST00000261206.3_Missense_Mutation_p.G314R			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	315						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GCCCACTGGGGGATACGCTGT	0.383000													16	87					0	0	1	0	0
TEC	7006	broad.mit.edu	37	4	48230567	48230567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48230567G>A	ENST00000381501.3	-	2	222	c.65C>T	c.(64-66)tCg>tTg	p.S22L		NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	22	PH.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						GTTTAAGGGCGATGTCTTCTT	0.388000													46	85					0	0	1	0	0
HAUS7	55559	broad.mit.edu	37	X	152728076	152728076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:152728076G>A	ENST00000370219.3	-	4	933	c.376C>T	c.(376-378)Ctc>Ttc	p.L126F	HAUS7_ENST00000421080.2_5'UTR|TREX2_ENST00000370232.1_5'UTR|TREX2_ENST00000338525.2_5'UTR|TREX2_ENST00000330912.2_5'UTR|HAUS7_ENST00000370210.1_Missense_Mutation_p.L116F|TREX2_ENST00000334497.2_5'UTR|HAUS7_ENST00000370212.3_Missense_Mutation_p.L126F|HAUS7_ENST00000370211.4_Missense_Mutation_p.L116F	NM_017518.6	NP_059988.3	Q99871	HAUS7_HUMAN	HAUS augmin-like complex, subunit 7	126					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding			endometrium(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)	19						ACCTTGAGGAGCTCCTGGTCA	0.587000													12	12					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815707	158815707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158815707G>A	ENST00000368141.4	+	5	1162	c.901G>A	c.(901-903)Gaa>Aaa	p.E301K		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	301	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					CAGAATTATCGAAATAGCAAA	0.338000													39	92					0	0	1	0	0
MUC5AC	4586	broad.mit.edu	37	11	1162237	1162237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1162237C>T	ENST00000356191.2	+	20	1737	c.1737C>T	c.(1735-1737)ttC>ttT	p.579_579insF						mucin 5AC, oligomeric mucus/gel-forming											NS(1)|breast(2)|central_nervous_system(7)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(5)|kidney(9)|large_intestine(19)|liver(1)|lung(89)|ovary(7)|prostate(8)|skin(9)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	203		all_cancers(49;2.94e-05)|Breast(177;0.00257)|all_epithelial(84;0.00314)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00146)|Lung(200;0.0612)|LUSC - Lung squamous cell carcinoma(625;0.0724)		CCGATGACTTCCGGACCCTCA	0.637000													8	17					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774731	122774731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:122774731C>T	ENST00000227349.2	+	3	740	c.443C>T	c.(442-444)cCg>cTg	p.P148L	C11orf63_ENST00000307257.6_Missense_Mutation_p.P148L|C11orf63_ENST00000531316.1_Missense_Mutation_p.P148L	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	148										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GAAGCGTTGCCGGAGTCCACG	0.527000													49	143					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94772593	94772593	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94772593G>A	ENST00000283357.5	+	7	922	c.876G>A	c.(874-876)atG>atA	p.M292I		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	292										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GCCACGAAATGAACCTTTTGG	0.378000													15	44					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152275534	152275534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152275534C>T	ENST00000368799.1	-	3	11863	c.11828G>A	c.(11827-11829)gGa>gAa	p.G3943E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3943	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTGTATTCCTGAGTGATA	0.433000									Ichthyosis				46	88					0	0	1	0	0
TXK	7294	broad.mit.edu	37	4	48076025	48076025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48076025G>A	ENST00000264316.4	-	13	1369	c.1284C>T	c.(1282-1284)ttC>ttT	p.F428F	TXK_ENST00000507351.1_Silent_p.F83F	NM_003328.2	NP_003319.2	P42681	TXK_HUMAN	TXK tyrosine kinase	428	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(2)	25						ACTTGATTGGGAACTTGGCTC	0.388000													9	90					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98186452	98186452	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:98186452G>A	ENST00000306031.5	-	6	640	c.514C>T	c.(514-516)Cat>Tat	p.H172Y	DPYD_ENST00000474241.1_5'UTR|DPYD_ENST00000370192.3_Intron|DPYD_ENST00000423006.2_Intron	NM_001160301.1	NP_001153773.1	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	0					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CTTTACAAATGATTCATTAAA	0.338000													4	23					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31654358	31654358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31654358G>A	ENST00000331728.4	+	3	312	c.198G>A	c.(196-198)ggG>ggA	p.G66G	LIMK2_ENST00000444929.2_Intron|LIMK2_ENST00000406516.1_5'UTR|LIMK2_ENST00000333611.4_Silent_p.G45G|LIMK2_ENST00000340552.4_Silent_p.G45G	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	66						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						ACTACTGGGGGAAGTTTGGGG	0.512000													41	56					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31317894	31317894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31317894G>A	ENST00000265071.2	+	11	2010	c.1745G>A	c.(1744-1746)gGg>gAg	p.G582E	CDH6_ENST00000514738.1_Missense_Mutation_p.G527E	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	582	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AGCAGCACTGGGACAGTGACT	0.542000													22	49					0	0	1	0	0
MT1L	4500	broad.mit.edu	37	16	56651395	56651395	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56651395G>A	ENST00000565768.1	+	0	8					NR_001447.2				metallothionein 1L (gene/pseudogene)																		CCTGCAAAAGGAGCAGCTGGC	0.662000													14	28					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95847290	95847290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95847290C>T	ENST00000398107.2	+	4	1113	c.591C>T	c.(589-591)ttC>ttT	p.F197F	ZNF2_ENST00000425369.1_Silent_p.F159F|ZNF2_ENST00000295210.6_Silent_p.F201F|ZNF2_ENST00000340539.5_Silent_p.F239F|ZNF2_ENST00000453539.2_Silent_p.F252F	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		CAAAAGCCTTCTTTGACCGTT	0.522000													16	131					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50781399	50781399	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50781399G>A	ENST00000440075.2	+	30	3932	c.3885G>A	c.(3883-3885)cgG>cgA	p.R1295R	MYH14_ENST00000425460.1_Silent_p.R1262R|MYH14_ENST00000376970.2_Silent_p.R1287R|MYH14_ENST00000598205.1_Silent_p.R1262R|MYH14_ENST00000596571.1_Silent_p.R1254R|MYH14_ENST00000262269.8_Silent_p.R1295R|MYH14_ENST00000601313.1_Silent_p.R1295R			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1254					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CCGAGCTGCGGGCAGAACTGA	0.642000													7	25					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18384706	18384706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18384706G>A	ENST00000441493.2	-	5	981	c.629C>T	c.(628-630)cCt>cTt	p.P210L	MICAL3_ENST00000444520.1_Missense_Mutation_p.P210L|MICAL3_ENST00000429452.1_Missense_Mutation_p.P210L|MICAL3_ENST00000585038.1_Missense_Mutation_p.P210L|MICAL3_ENST00000207726.7_Missense_Mutation_p.P210L|MICAL3_ENST00000400561.2_Missense_Mutation_p.P210L|MICAL3_ENST00000383094.3_Missense_Mutation_p.P210L|MICAL3_ENST00000414725.2_Missense_Mutation_p.P210L	NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	210						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CTCTGACACAGGATGAGTCTT	0.537000													13	26					0	0	1	0	0
MOGAT2	80168	broad.mit.edu	37	11	75442214	75442214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75442214C>T	ENST00000526712.1	+	5	1415	c.642C>T	c.(640-642)ccC>ccT	p.P214P	MOGAT2_ENST00000198801.5_Silent_p.P296P			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	296					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					CGCTGCATCCCTCGGAGGAGG	0.577000													24	60					0	0	1	0	0
MYSM1	114803	broad.mit.edu	37	1	59126874	59126874	+	Missense_Mutation	SNP	G	G	A	rs141454457		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:59126874G>A	ENST00000472487.1	-	19	2335	c.2296C>T	c.(2296-2298)Cgc>Tgc	p.R766C	MYSM1_ENST00000493821.1_5'UTR	NM_001085487.2	NP_001078956.1	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	766					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.R766C(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(7;9.36e-06)					GAATCCCGGCGAAAGATTTTA	0.363000													23	50					0	0	1	0	0
WDR47	22911	broad.mit.edu	37	1	109538218	109538218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109538218G>A	ENST00000357672.3	-	7	1966	c.1591C>T	c.(1591-1593)Cct>Tct	p.P531S	WDR47_ENST00000369965.4_Missense_Mutation_p.P560S|WDR47_ENST00000400794.3_Missense_Mutation_p.P567S|WDR47_ENST00000369962.3_Missense_Mutation_p.P559S|WDR47_ENST00000361054.3_Missense_Mutation_p.P531S			O94967	WDR47_HUMAN	WD repeat domain 47	559										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CTTCCACAAGGTGATTCCTCC	0.363000													74	225					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1092165	1092165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1092165G>A	ENST00000441003.2	+	30	4011	c.3984G>A	c.(3982-3984)ggG>ggA	p.G1328G	MUC2_ENST00000359061.5_Silent_p.G1329G	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1328						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CATTTGATGGGGTCTGCGGGG	0.587000													7	20					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2855544	2855544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2855544G>A	ENST00000520002.1	-	55	8924	c.8369C>T	c.(8368-8370)cCc>cTc	p.P2790L	CSMD1_ENST00000542608.1_Missense_Mutation_p.P2731L|CSMD1_ENST00000537824.1_Missense_Mutation_p.P2789L|CSMD1_ENST00000602723.1_Missense_Mutation_p.P2732L|CSMD1_ENST00000400186.3_Missense_Mutation_p.P2732L|CSMD1_ENST00000602557.1_Missense_Mutation_p.P2790L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2790	Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCGACACGTGGGCAGAGGGCT	0.552000													9	29					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12979590	12979590	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12979590G>A	ENST00000251472.4	+	21	2739	c.2700G>A	c.(2698-2700)aaG>aaA	p.K900K		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	900					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CAGTAGAGAAGAGGCCTTCTC	0.592000													9	147					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	73013479	73013479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73013479G>A	ENST00000308744.6	+	4	1617	c.1519G>A	c.(1519-1521)Gaa>Aaa	p.E507K	NPFFR2_ENST00000506359.1_3'UTR|NPFFR2_ENST00000395999.1_Missense_Mutation_p.E408K|NPFFR2_ENST00000344413.5_3'UTR|NPFFR2_ENST00000358749.3_Missense_Mutation_p.E405K	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	507					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			ACCCCAACAGGAATTAGTGAT	0.348000													22	61					0	0	1	0	0
TSKU	25987	broad.mit.edu	37	11	76506753	76506753	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76506753C>T	ENST00000527881.1	+	2	1119	c.93C>T	c.(91-93)ttC>ttT	p.F31F	TSKU_ENST00000333090.4_Silent_p.F31F			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	31	LRRNT.					extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					TGGAGACCTTCGGCCTTTTCG	0.672000													7	61					0	0	1	0	0
HPD	3242	broad.mit.edu	37	12	122281721	122281721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122281721C>T	ENST00000543163.1	-	13	1177	c.732G>A	c.(730-732)gaG>gaA	p.E244E	HPD_ENST00000289004.4_Silent_p.E283E	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	283					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	CCAGGCCTCTCTCTCTCAAGT	0.532000													23	39					0	0	1	0	0
CLDN19	149461	broad.mit.edu	37	1	43203960	43203960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43203960G>A	ENST00000296387.1	-	3	603	c.413C>T	c.(412-414)tCg>tTg	p.S138L	CLDN19_ENST00000539749.1_Intron|CLDN19_ENST00000372539.3_Missense_Mutation_p.S138L	NM_001123395.1|NM_148960.2	NP_001116867.1|NP_683763.2	Q8N6F1	CLD19_HUMAN	claudin 19	138					calcium-independent cell-cell adhesion|response to stimulus|visual perception	basolateral plasma membrane|integral to membrane|tight junction	identical protein binding			breast(2)|large_intestine(1)|lung(2)|skin(1)	6	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGCATACCACGAGACAGCAGT	0.612000													15	71					0	0	1	0	0
FOLR1	2348	broad.mit.edu	37	11	71907116	71907116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71907116G>A	ENST00000393679.1	+	5	1105	c.669G>A	c.(667-669)gaG>gaA	p.E223E	FOLR1_ENST00000312293.4_Silent_p.E223E|FOLR1_ENST00000393681.2_Silent_p.E223E|FOLR1_ENST00000393676.3_Silent_p.E223E|RP11-807H22.7_ENST00000378140.3_RNA			P15328	FOLR1_HUMAN	folate receptor 1 (adult)	223					cell death|folic acid transport|receptor-mediated endocytosis	anchored to membrane|extracellular region|integral to plasma membrane|membrane fraction	folic acid binding|receptor activity			cervix(2)|endometrium(1)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	14						ACCCCAATGAGGAGGTGGCGA	0.607000													13	69					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61986905	61986905	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:61986905C>T	ENST00000409186.1	-	5	3432	c.1327G>A	c.(1327-1329)Gaa>Aaa	p.E443K	PCDH20_ENST00000409204.4_Missense_Mutation_p.E443K			Q8N6Y1	PCD20_HUMAN	protocadherin 20	416	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGTTCCAGTTCTTTCAGATAA	0.418000													35	103					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066875	46066875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46066875C>T	ENST00000334670.8	+	1	545	c.500C>T	c.(499-501)tCa>tTa	p.S167L	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	161	25 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						GATTCCTCTTCATGCTGCCAG	0.617000													63	253					0	0	1	0	0
AADACL3	126767	broad.mit.edu	37	1	12785679	12785679	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12785679G>A	ENST00000332530.3	+	3	785	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K	AADACL3_ENST00000359318.5_Missense_Mutation_p.E257K	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	257							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTTACTTGGAAGTAAGTGT	0.502000													63	120					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325407	47325407	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47325407G>A	ENST00000505841.1	-	0	1122					NR_002788.2																						GCGTAGAGGCGGAGGCATTCC	0.493000													20	87					0	0	1	0	0
SLC30A1	7779	broad.mit.edu	37	1	211749497	211749497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:211749497G>A	ENST00000367001.4	-	2	886	c.757C>T	c.(757-759)Ctt>Ttt	p.L253F		NM_021194.2	NP_067017.2	Q9Y6M5	ZNT1_HUMAN	solute carrier family 30 (zinc transporter), member 1	253					cadmium ion transmembrane transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|negative regulation of calcium ion import|negative regulation of neurotransmitter secretion|negative regulation of zinc ion import	integral to membrane|T-tubule	calcium channel inhibitor activity|zinc ion transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(3)|prostate(1)	11				OV - Ovarian serous cystadenocarcinoma(81;0.00535)|GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.0604)|Epithelial(68;0.0978)		GCATCTCCAAGGACATGCAGA	0.413000													25	77					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2376115	2376115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2376115G>A	ENST00000301732.5	-	5	915	c.215C>T	c.(214-216)cCt>cTt	p.P72L	ABCA3_ENST00000567910.1_Missense_Mutation_p.P72L|ABCA3_ENST00000382381.3_Missense_Mutation_p.P72L	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	72					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				TCCTGGCGGAGGGAAGGTGAA	0.577000													10	50					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10446015	10446015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:10446015G>A	ENST00000326756.3	-	3	2376	c.1938C>T	c.(1936-1938)gtC>gtT	p.V646V		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						TGCCCTCGGGGACATTTTCAG	0.408000													50	147					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111138100	111138100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111138100C>T	ENST00000360467.5	+	34	3430	c.3124C>T	c.(3124-3126)Ccc>Tcc	p.P1042S		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1042	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CATCGGAGTCCCCGGCATCCC	0.617000													30	63					0	0	1	0	0
RMND5A	64795	broad.mit.edu	37	2	86980590	86980590	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:86980590C>T	ENST00000283632.4	+	4	925	c.430C>T	c.(430-432)Ctt>Ttt	p.L144F		NM_022780.3	NP_073617.1	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	144	LisH.									kidney(1)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	17						GGAATCTGGTCTTTCTGTAGA	0.373000													45	96					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117810748	117810748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117810748G>A	ENST00000350763.4	-	16	5054	c.4643C>T	c.(4642-4644)tCc>tTc	p.S1548F	TNC_ENST00000341037.4_Intron|TNC_ENST00000542877.1_Intron|TNC_ENST00000340094.3_Missense_Mutation_p.S1184F|TNC_ENST00000537320.1_Intron|TNC_ENST00000535648.1_Intron|TNC_ENST00000423613.2_Intron|TNC_ENST00000345230.3_Intron|TNC_ENST00000481475.1_5'UTR|TNC_ENST00000346706.3_Intron	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1548	Fibronectin type-III 11.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TGCCATCCAGGAAACTGTGAA	0.502000													9	40					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3101050	3101050	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3101050C>T	ENST00000355072.5	+	3	542	c.397C>T	c.(397-399)Ctg>Ttg	p.L133L		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	133					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGAACTTTTTCTGCTGTGCAG	0.438000													9	88					0	0	1	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516120	138516120	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138516120G>A	ENST00000371763.1	-	5	907	c.654C>T	c.(652-654)atC>atT	p.I218I		NM_182974.2	NP_892019.2	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	218					carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	15		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		GTCCAAACGGGATGCAAGCTG	0.493000													18	100					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23224167	23224167	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23224167G>T	ENST00000300061.2	+	10	1526	c.1383G>T	c.(1381-1383)gaG>gaT	p.E461D	CTC-391G2.1_ENST00000563471.1_RNA	NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	461				EWT -> DGH (in Ref. 5; AAC50758).	excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GCTTTAAAGAGTGGACACTAA	0.592000													10	72					1.58986e-06	1.59358e-06	1	1	0
COL17A1	1308	broad.mit.edu	37	10	105840406	105840406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105840406C>T	ENST00000353479.5	-	2	316	c.26G>A	c.(25-27)cGa>cAa	p.R9Q	COL17A1_ENST00000369733.3_Missense_Mutation_p.R9Q|COL17A1_ENST00000393211.3_Missense_Mutation_p.R9Q	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	9	Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGTTCCATCTCGTTTGTTTTT	0.308000													32	87					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103326685	103326685	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:103326685T>A	ENST00000376052.3	+	28	3440	c.3424T>A	c.(3424-3426)Tgt>Agt	p.C1142S	TPP2_ENST00000466153.1_3'UTR|TPP2_ENST00000376065.4_Missense_Mutation_p.C1129S			P29144	TPP2_HUMAN	tripeptidyl peptidase II	1129					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TAGGAAAGGTTGTGCCCTGGC	0.433000													25	59					0	0	1	0	0
OR5I1	10798	broad.mit.edu	37	11	55703443	55703443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55703443C>T	ENST00000301532.3	-	1	433	c.434G>A	c.(433-435)cGg>cAg	p.R145Q		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GACAATCAACCGCATACAGAT	0.428000													29	71					0	0	1	0	0
C4orf17	84103	broad.mit.edu	37	4	100443816	100443816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100443816G>A	ENST00000514652.1	+	3	641	c.287G>A	c.(286-288)gGa>gAa	p.G96E	C4orf17_ENST00000326581.4_Missense_Mutation_p.G96E|C4orf17_ENST00000503257.1_3'UTR			Q53FE4	CD017_HUMAN	chromosome 4 open reading frame 17	96										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		CCTGTAAGAGGAATGTCGCCA	0.507000													24	85					0	0	1	0	0
MLNR	2862	broad.mit.edu	37	13	49796481	49796481	+	Missense_Mutation	SNP	G	G	A	rs141878008		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:49796481G>A	ENST00000218721.1	+	2	1207	c.1207G>A	c.(1207-1209)Gag>Aag	p.E403K	MLNR_ENST00000398307.1_3'UTR	NM_001507.1	NP_001498.1	O43193	MTLR_HUMAN	motilin receptor	403					digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity			endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)	14		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		GGGCTACACCGAGACAAGCGC	0.572000													4	20					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	818396	818396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:818396G>A	ENST00000566549.1	+	16	2031	c.1614G>A	c.(1612-1614)gaG>gaA	p.E538E	MSLN_ENST00000545450.2_Silent_p.E538E|MSLN_ENST00000382862.3_Silent_p.E546E|MSLN_ENST00000563941.1_Silent_p.E538E			Q13421	MSLN_HUMAN	mesothelin	546					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				CTGTGGCTGAGGTGCAGAAAC	0.682000													10	25					0	0	1	0	0
CD19	930	broad.mit.edu	37	16	28944640	28944640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28944640C>T	ENST00000538922.1	+	4	707	c.645C>T	c.(643-645)acC>acT	p.T215T	CD19_ENST00000567541.1_Silent_p.T215T|CD19_ENST00000324662.3_Silent_p.T215T	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	215	Ig-like C2-type 2.				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						TCTCCTGGACCCATGTGCACC	0.622000													17	33					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179449278	179449278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179449278C>T	ENST00000589042.1	-	311	65224	c.65000G>A	c.(64999-65001)cGa>cAa	p.R21667Q	TTN_ENST00000342992.6_Missense_Mutation_p.R19099Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R12602Q|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R12794Q|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R12727Q|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R20026Q|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20026	Fibronectin type-III 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R12794P(1)|p.R19099P(1)|p.R19097P(1)|p.R12602P(1)|p.R12727P(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGTGACTCGTGCATTCTT	0.398000													27	48					0	0	1	0	0
RNF217	154214	broad.mit.edu	37	6	125284084	125284084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:125284084G>A	ENST00000521654.2	+	1	394	c.394G>A	c.(394-396)Gag>Aag	p.E132K	RNF217_ENST00000560949.1_5'UTR|RP11-510H23.1_ENST00000439075.1_RNA			Q8TC41	RN217_HUMAN	ring finger protein 217	0					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		CCCCGGCGAAGAGCTGGAGCC	0.672000													6	19					0	0	1	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89476605	89476605	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89476605G>A	ENST00000484817.1	-	0	39																											AGCTGAGCAAGGAGCCTCATT	0.552000													5	27					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1230951	1230951	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:1230951C>T	ENST00000381312.1	-	9	2218	c.1893G>A	c.(1891-1893)ccG>ccA	p.P631P	ADARB2_ENST00000381305.1_Silent_p.P33P|ADARB2_ENST00000381310.3_Silent_p.P140P	NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	631	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCGACTTCCCCGGCTGGCGCG	0.682000													6	39					0	0	1	0	0
ZNF610	162963	broad.mit.edu	37	19	52869802	52869802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52869802C>T	ENST00000601151.1	+	5	1494	c.1042C>T	c.(1042-1044)Ctt>Ttt	p.L348F	ZNF610_ENST00000321287.8_Missense_Mutation_p.L391F|ZNF610_ENST00000327920.8_Missense_Mutation_p.L391F|ZNF610_ENST00000403906.3_Missense_Mutation_p.L391F	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		TATGGCCCATCTTCTAATCCA	0.413000													21	71					0	0	1	0	0
GNL2	29889	broad.mit.edu	37	1	38034744	38034744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38034744G>A	ENST00000373062.3	-	13	1674	c.1576C>T	c.(1576-1578)Ctc>Ttc	p.L526F	GNL2_ENST00000462812.1_5'UTR	NM_013285.2	NP_037417.1	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2 (nucleolar)	526					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				ACTCGTGTGAGAATCTGCTGC	0.473000													36	81					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4950860	4950860	+	Missense_Mutation	SNP	C	C	T	rs149764746	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4950860C>T	ENST00000345988.2	-	6	666	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K	PPL_ENST00000590782.2_Missense_Mutation_p.E191K	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	193					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GCCCGGAGTTCGCTGTTCTGC	0.657000													56	207					0	0	1	0	0
SDF2L1	23753	broad.mit.edu	37	22	21998345	21998345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21998345C>T	ENST00000248958.4	+	3	623	c.547C>T	c.(547-549)Cgt>Tgt	p.R183C		NM_022044.2	NP_071327.2	Q9HCN8	SDF2L_HUMAN	stromal cell-derived factor 2-like 1	183	MIR 3.					endoplasmic reticulum lumen|membrane				prostate(1)	1	Colorectal(54;0.105)					AAGCCCCATCCGTGGGCAGCA	0.602000											OREG0026342	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	30					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30961695	30961695	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30961695G>A	ENST00000311813.4	+	2	454	c.399G>A	c.(397-399)gtG>gtA	p.V133V	AQP1_ENST00000509504.1_Silent_p.V310V|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000409611.1_Silent_p.V82V|AQP1_ENST00000409899.1_Silent_p.V18V|AQP1_ENST00000441328.2_Silent_p.V50V|AQP1_ENST00000434909.2_Silent_p.V193V	NM_198098.2	NP_932766.1			aquaporin 1											kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				CTGATGGTGTGAACTCGGGCC	0.652000													29	77					0	0	1	0	0
CXCR2P1	3580	broad.mit.edu	37	2	218925040	218925040	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:218925040G>A	ENST00000439871.1	-	0	1340					NR_002712.1																						AACCCCACGGGACTGCACTTA	0.552000													25	81					0	0	1	0	0
ZSCAN23	222696	broad.mit.edu	37	6	28403922	28403922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28403922G>A	ENST00000289788.4	-	2	267	c.122C>T	c.(121-123)cCt>cTt	p.P41L	ZSCAN23_ENST00000486481.1_Intron	NM_001012455.1	NP_001012458.1	Q3MJ62	ZSC23_HUMAN	zinc finger and SCAN domain containing 23	41					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|prostate(1)|stomach(2)	4						TCTGGTATGAGGGTTATTTCT	0.537000													4	10					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239360	5239360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:5239360C>T	ENST00000274181.7	+	15	2389	c.2251C>T	c.(2251-2253)Ctc>Ttc	p.L751F		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	751	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TCACAGGGGTCTCTACACCAA	0.512000													39	152					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105386875	105386875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105386875G>A	ENST00000369774.4	-	9	965	c.689C>T	c.(688-690)tCc>tTc	p.S230F	SH3PXD2A_ENST00000540321.1_Missense_Mutation_p.S97F|SH3PXD2A_ENST00000538130.1_Missense_Mutation_p.S65F|SH3PXD2A_ENST00000427662.2_Missense_Mutation_p.S92F|SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.S230F			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	230					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GTTGATGTCGGAGTCATCCCG	0.607000													28	83					0	0	1	0	0
HCAR1	27198	broad.mit.edu	37	12	123214755	123214755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123214755C>T	ENST00000432564.1	-	1	374	c.132G>A	c.(130-132)atG>atA	p.M44I	HCAR1_ENST00000356987.2_Missense_Mutation_p.M44I|HCAR1_ENST00000436083.2_Missense_Mutation_p.M44I	NM_032554.3	NP_115943.1	Q9BXC0	HCAR1_HUMAN	hydroxycarboxylic acid receptor 1	44					response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)	10						TCCAGGTCTTCATGTGGAAGC	0.547000													9	27					0	0	1	0	0
KLHL8	57563	broad.mit.edu	37	4	88106515	88106515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88106515G>A	ENST00000273963.5	-	3	994	c.653C>T	c.(652-654)tCc>tTc	p.S218F	KLHL8_ENST00000512111.1_Missense_Mutation_p.S218F|KLHL8_ENST00000498875.2_Missense_Mutation_p.S142F|KLHL8_ENST00000545252.1_Intron|KLHL8_ENST00000425278.2_Intron	NM_020803.3	NP_065854.3	Q9P2G9	KLHL8_HUMAN	kelch-like family member 8	218										breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		ATCACTGGAGGACAAAAGCTT	0.428000													15	139					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214813331	214813331	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:214813331C>T	ENST00000366955.3	+	12	1818	c.1650C>T	c.(1648-1650)tcC>tcT	p.S550S		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	550					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAGAAAACTCCTTGACTTTAG	0.343000													75	169					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19195304	19195304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19195304C>T	ENST00000562034.1	+	3	4401	c.603C>T	c.(601-603)ttC>ttT	p.F201F	SYT17_ENST00000355377.2_Silent_p.F262F|SYT17_ENST00000568115.1_Silent_p.F201F|SYT17_ENST00000562711.2_Silent_p.F258F			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	262	C2 1.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						GCTACACCTTCGAGATCCCCT	0.557000													62	112					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48266805	48266805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48266805C>T	ENST00000302329.3	+	1	198	c.150C>T	c.(148-150)ccC>ccT	p.P50P		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P50P(1)		breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						TTGGTTCCCCCATGTACTTCT	0.488000													31	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438751	179438751	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179438751C>T	ENST00000589042.1	-	326	72332	c.72108G>A	c.(72106-72108)aaG>aaA	p.K24036K	TTN_ENST00000342992.6_Silent_p.K21468K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Silent_p.K14971K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.K15163K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.K15096K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Silent_p.K22395K|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22395	Fibronectin type-III 74.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACCGTGTCCTTAAATTTAA	0.463000													19	29					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50467665	50467665	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50467665G>A	ENST00000331340.3	+	8	1055	c.900G>A	c.(898-900)gaG>gaA	p.E300E	IKZF1_ENST00000359197.5_Silent_p.E258E|IKZF1_ENST00000343574.5_Silent_p.E213E|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000346667.4_Silent_p.E70E|IKZF1_ENST00000438033.1_Silent_p.E213E|IKZF1_ENST00000357364.4_Silent_p.E213E|IKZF1_ENST00000349824.4_Silent_p.E157E|IKZF1_ENST00000439701.1_Silent_p.E258E	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	300					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CCAGCTACGAGAAGGAGAACG	0.637000			"""D,T"""	BCL6	"""ALL, DLBCL"""								10	27					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958050	121958050	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121958050C>T	ENST00000379692.4	-	4	1602	c.1076G>A	c.(1075-1077)gGa>gAa	p.G359E		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	359										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						AAACTTTGCTCCCTTCCTTTT	0.423000													43	99					0	0	1	0	0
CPA5	93979	broad.mit.edu	37	7	129986368	129986368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129986368C>T	ENST00000485477.1	+	2	1171	c.42C>T	c.(40-42)tcC>tcT	p.S14S	CPA5_ENST00000431780.2_Silent_p.S14S|CPA5_ENST00000474905.1_Silent_p.S14S|CPA5_ENST00000355388.3_Silent_p.S14S|CPA5_ENST00000461828.1_Silent_p.S14S|CPA5_ENST00000393213.3_Silent_p.S14S|CPA5_ENST00000466363.2_Silent_p.S14S			Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5	14					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(2)|breast(2)|endometrium(2)|large_intestine(7)|lung(4)|ovary(3)|pancreas(1)|skin(2)	23	Melanoma(18;0.0435)					CTGGGCCATCCCCCGTGGACA	0.632000													25	88					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14857646	14857646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14857646G>A	ENST00000380881.4	-	6	1548	c.733C>T	c.(733-735)Ctt>Ttt	p.L245F	FREM1_ENST00000422223.2_Missense_Mutation_p.L245F|FREM1_ENST00000380880.3_Missense_Mutation_p.L245F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	245					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TGATAACGAAGGCCCATCAGC	0.473000													32	61					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24448182	24448182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24448182G>A	ENST00000230036.1	-	17	1711	c.1601C>T	c.(1600-1602)tCc>tTc	p.S534F		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	534				VIGS -> MLGT (in Ref. 6; AA sequence).		extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TGCAAAAGGGGAGCCGATGAC	0.532000													16	55					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167272581	167272581	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167272581C>T	ENST00000308378.3	-	6	962	c.657G>A	c.(655-657)tgG>tgA	p.W219*	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Nonsense_Mutation_p.W272*|WDR49_ENST00000476376.1_Nonsense_Mutation_p.W44*	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	219										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CATTGAAGTCCCATATCTTTA	0.318000													42	97					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53104125	53104125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:53104125C>T	ENST00000408890.4	+	1	777	c.761C>T	c.(760-762)tCc>tTc	p.S254F		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	254										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GCTTGGCCTTCCGTGCTGGTC	0.637000													33	61					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65008433	65008433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65008433C>T	ENST00000247207.6	+	1	1248	c.866C>T	c.(865-867)tCg>tTg	p.S289L	HSPA2_ENST00000394709.1_Missense_Mutation_p.S289L	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	289					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GAGATCGACTCGCTCTACGAG	0.667000													8	19					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26695003	26695003	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26695003C>T	ENST00000396005.3	-	14	1962	c.1653G>A	c.(1651-1653)aaG>aaA	p.K551K		NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	551					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						TTTTGTACTTCTTAGACCAAA	0.388000													54	143					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32145279	32145279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32145279G>A	ENST00000373672.3	-	42	3242	c.2726C>T	c.(2725-2727)cCa>cTa	p.P909L	COL16A1_ENST00000373668.3_Missense_Mutation_p.P893L|COL16A1_ENST00000271069.6_Missense_Mutation_p.P908L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	909	Triple-helical region 4 (COL4) with 2 imperfections.		P -> L (in dbSNP:rs2229804).		cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGAATACCTGGTGGACCCTG	0.627000													46	140					0	0	1	0	0
POMT2	29954	broad.mit.edu	37	14	77750178	77750178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77750178G>A	ENST00000261534.4	-	15	1817	c.1615C>T	c.(1615-1617)Cct>Tct	p.P539S		NM_013382.5	NP_037514.2	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	539					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		AAGATCTCAGGAAAACTGGGC	0.473000													34	84					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52573812	52573812	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52573812C>T	ENST00000395489.2	-	12	1527	c.1131G>A	c.(1129-1131)atG>atA	p.M377I	A1CF_ENST00000493415.1_Intron|A1CF_ENST00000373993.1_Missense_Mutation_p.M384I|A1CF_ENST00000282641.2_Missense_Mutation_p.M384I|ASAH2B_ENST00000483649.1_Intron|A1CF_ENST00000373997.3_Intron|A1CF_ENST00000374001.1_Intron|A1CF_ENST00000395495.1_Missense_Mutation_p.M329I|A1CF_ENST00000373995.3_Intron	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	384	Required for nuclear localization.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CAGGTACATTCATGTAAATTT	0.468000													26	65					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247836280	247836280	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247836280C>T	ENST00000359688.2	-	1	85	c.64G>A	c.(64-66)Gga>Aga	p.G22R	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AAGATAATTCCCTGGAGTTCA	0.423000													37	72					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220168485	220168485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220168485G>A	ENST00000295718.2	-	4	589	c.349C>T	c.(349-351)Cgc>Tgc	p.R117C	PTPRN_ENST00000423636.2_Missense_Mutation_p.R27C|PTPRN_ENST00000409251.3_Missense_Mutation_p.R117C|AC114803.3_ENST00000417355.1_RNA	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	117					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCTGGGGGGCGAAGCCTGGGG	0.542000													12	36					0	0	1	0	0
NDRG4	65009	broad.mit.edu	37	16	58538273	58538273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58538273C>T	ENST00000394282.4	+	6	822	c.415C>T	c.(415-417)Ccc>Tcc	p.P139S	NDRG4_ENST00000570248.1_Missense_Mutation_p.P87S|NDRG4_ENST00000394279.2_Missense_Mutation_p.P119S|NDRG4_ENST00000258187.5_Missense_Mutation_p.P119S|NDRG4_ENST00000566192.1_Missense_Mutation_p.P87S|NDRG4_ENST00000568640.1_Missense_Mutation_p.P105S|NDRG4_ENST00000356752.4_Missense_Mutation_p.P117S|NDRG4_ENST00000562999.1_Missense_Mutation_p.P87S|NDRG4_ENST00000569923.1_Missense_Mutation_p.P32S|NDRG4_ENST00000563799.1_Missense_Mutation_p.P105S	NM_001130487.1	NP_001123959.1	Q9ULP0	NDRG4_HUMAN	NDRG family member 4	87					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				breast(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	11						GTACCAGTTCCCCTCCATGGA	0.677000													66	164					0	0	1	0	0
DUSP26	78986	broad.mit.edu	37	8	33454981	33454981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:33454981G>A	ENST00000256261.4	-	2	570	c.53C>T	c.(52-54)tCc>tTc	p.S18F	DUSP26_ENST00000523956.1_Missense_Mutation_p.S18F	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	18						Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		GCTACTCCGGGAGAAGCGGGC	0.552000													10	38					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093412	30093412	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30093412C>T	ENST00000567636.1	+	0	1787					NR_003558.1																						AGCTCCCTTGCTGAACCCTGA	0.527000													12	120					0	0	1	0	0
ISL1	3670	broad.mit.edu	37	5	50679518	50679518	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50679518G>A	ENST00000230658.7	+	1	598	c.13G>A	c.(13-15)Gga>Aga	p.G5R	ISL1_ENST00000511384.1_Missense_Mutation_p.G5R	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	5					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				GGGAGACATGGGAGATCCACC	0.522000													20	54					0	0	1	0	0
TECTB	6975	broad.mit.edu	37	10	114053792	114053792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:114053792C>T	ENST00000369422.3	+	6	644	c.644C>T	c.(643-645)cCc>cTc	p.P215L		NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	215	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		TTCATGTATCCCTTGCAGTGG	0.478000													11	40					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39001159	39001159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39001159G>A	ENST00000355481.4	+	59	9085	c.8954G>A	c.(8953-8955)cGa>cAa	p.R2985Q	RYR1_ENST00000360985.3_Missense_Mutation_p.R2985Q|RYR1_ENST00000359596.3_Missense_Mutation_p.R2985Q	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2985					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.R2985L(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGCAGTGGGCGAGTGGAAAAG	0.562000													20	106					0	0	1	0	0
RPL10L	140801	broad.mit.edu	37	14	47120366	47120366	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:47120366G>A	ENST00000298283.3	-	1	662	c.574C>T	c.(574-576)Cct>Tct	p.P192S		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	192					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						CAACCATCAGGGATGAGGCAC	0.517000													41	83					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527500	23527500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:23527500G>A	ENST00000296682.3	+	11	2485	c.2303G>A	c.(2302-2304)aGg>aAg	p.R768K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	768					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGACACCAGAGGACACACACA	0.582000										HNSCC(3;0.000094)			26	197					0	0	1	0	0
SLC25A40	55972	broad.mit.edu	37	7	87466116	87466116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87466116G>A	ENST00000341119.5	-	11	1179	c.833C>T	c.(832-834)cCt>cTt	p.P278L		NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40	278					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					CATATGCAAAGGCATAGAAAC	0.299000													27	47					0	0	1	0	0
ARSF	416	broad.mit.edu	37	X	3019165	3019165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3019165G>A	ENST00000381127.1	+	8	1226	c.1005G>A	c.(1003-1005)agG>agA	p.R335R	ARSF_ENST00000359361.2_Silent_p.R335R|ARSF_ENST00000537104.1_Silent_p.R335R	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	335						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTGGCCTAAGGAACAACACCC	0.408000													26	19					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043735	20043735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20043735G>A	ENST00000570682.1	-	2	684	c.384C>T	c.(382-384)atC>atT	p.I128I		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	128						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						GGCAGACAGCGATATACCTGT	0.507000													23	72					0	0	1	0	0
MBL1P	8512	broad.mit.edu	37	10	81680793	81680793	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81680793G>A	ENST00000480805.1	+	0	860					NR_002724.2																						CAGGACCTAGGGGCCAAAAAG	0.602000													6	10					0	0	1	0	0
FAM118A	55007	broad.mit.edu	37	22	45719239	45719239	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45719239C>T	ENST00000216214.3	+	4	1065	c.231C>T	c.(229-231)ttC>ttT	p.F77F	FAM118A_ENST00000405673.1_Silent_p.F77F|FAM118A_ENST00000441876.2_Silent_p.F77F	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	77						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TCGCCGAGTTCCGGAGGAAAG	0.592000													11	89					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34100769	34100769	+	Missense_Mutation	SNP	G	G	A	rs452752		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34100769G>A	ENST00000374181.3	-	1	674	c.505C>T	c.(505-507)Ctt>Ttt	p.L169F	GRM4_ENST00000374177.3_Intron|GRM4_ENST00000538487.1_Missense_Mutation_p.L169F	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	169			L -> F (in dbSNP:rs452752).		activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	AAGAGGCGAAGGATGTTGGCC	0.632000													17	29					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771993	143771993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143771993C>T	ENST00000408898.2	+	1	719	c.681C>T	c.(679-681)atC>atT	p.I227I		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					TTCTAAAGATCCAGTCAGGAG	0.478000													27	117					0	0	1	0	0
FKBP2	2286	broad.mit.edu	37	11	64010708	64010708	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64010708T>C	ENST00000394540.3	+	3	679	c.209T>C	c.(208-210)cTg>cCg	p.L70P	FKBP2_ENST00000449942.2_Missense_Mutation_p.L70P|FKBP2_ENST00000309366.4_Missense_Mutation_p.L70P	NM_057092.2	NP_476433.1	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa	70	PPIase FKBP-type.				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			endometrium(2)|lung(3)	5						GACAGCAGCCTGCCCCAGAAC	0.622000													7	57					0	0	1	0	0
GPR84	53831	broad.mit.edu	37	12	54756536	54756536	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54756536G>T	ENST00000551809.1	-	1	1735	c.1100C>A	c.(1099-1101)cCt>cAt	p.P367H	GPR84_ENST00000267015.3_Missense_Mutation_p.P367H|RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA			Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	367						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P367H(1)		NS(1)|breast(2)|kidney(2)|large_intestine(6)|lung(5)|skin(1)|urinary_tract(1)	18						ATAGAGCACAGGGTTGATGCA	0.542000													84	209					2.5963e-48	2.61523e-48	1	1	0
GJA3	2700	broad.mit.edu	37	13	20717051	20717051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:20717051G>A	ENST00000241125.3	-	2	553	c.377C>T	c.(376-378)cCg>cTg	p.P126L		NM_021954.3	NP_068773.2	Q9Y6H8	CXA3_HUMAN	gap junction protein, alpha 3, 46kDa	126					cell-cell signaling|visual perception	connexon complex|integral to membrane				NS(1)|endometrium(1)|kidney(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		all_cancers(29;1.4e-21)|all_epithelial(30;8.75e-19)|all_lung(29;1.28e-17)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000554)|Epithelial(112;0.000872)|OV - Ovarian serous cystadenocarcinoma(117;0.0105)|Lung(94;0.0251)|LUSC - Lung squamous cell carcinoma(192;0.0784)		ATTGTCCTGCGGTGGCTCCTT	0.632000													3	8					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26242107	26242107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26242107C>T	ENST00000335473.7	+	19	3659	c.3409C>T	c.(3409-3411)Cct>Tct	p.P1137S	MYO18B_ENST00000536101.1_Missense_Mutation_p.P1137S|MYO18B_ENST00000407587.2_Missense_Mutation_p.P1138S	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1137	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGCCAAGCTGCCTCCTGTGTG	0.652000													5	18					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105484080	105484080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105484080C>T	ENST00000369774.4	-	5	622	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.E116K			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	116	PX.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CGGAAGACTTCGTCACACTGT	0.552000													14	27					0	0	1	0	0
MIR543	100126335	broad.mit.edu	37	14	101498367	101498367	+	RNA	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101498367A>C	ENST00000390751.1	+	0	44					NR_030619.1																						TTTATTTGTGACGAAACATTC	0.502000													17	67					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31167799	31167799	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31167799C>T	ENST00000349752.5	-	8	1391	c.752G>A	c.(751-753)tGg>tAg	p.W251*	GALNT14_ENST00000420311.2_Nonsense_Mutation_p.W216*|GALNT14_ENST00000406653.1_Nonsense_Mutation_p.W231*|GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000356174.3_Nonsense_Mutation_p.W218*|GALNT14_ENST00000324589.5_Nonsense_Mutation_p.W256*	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	251						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					GTGGAGGCTCCAGTCAAACCC	0.577000													7	72					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614630	247614630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247614630G>A	ENST00000318749.6	-	1	678	c.655C>T	c.(655-657)Ctt>Ttt	p.L219F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	219					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TAGGAGAGAAGGATGAGAGCC	0.582000													11	64					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28710500	28710500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28710500C>T	ENST00000257198.5	-	16	2923	c.2662G>A	c.(2662-2664)Gca>Aca	p.A888T	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257197.3_3'UTR	NM_024421.2	NP_077739.1	Q08554	DSC1_HUMAN	desmocollin 1	888					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CATGTCTTTGCTAATGTCCTA	0.428000													38	185					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79165041	79165041	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79165041G>A	ENST00000269392.4	-	22	2973	c.2726C>T	c.(2725-2727)gCc>gTc	p.A909V	AZI1_ENST00000374782.3_Missense_Mutation_p.A870V|AZI1_ENST00000450824.2_Missense_Mutation_p.A906V|AZI1_ENST00000575907.1_Missense_Mutation_p.A873V	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	909					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGCCATGTCGGCCTCCAGCCG	0.652000													37	100					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10433021	10433021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10433021C>T	ENST00000245503.5	-	24	3361	c.2977G>A	c.(2977-2979)Gaa>Aaa	p.E993K	MYH2_ENST00000397183.2_Missense_Mutation_p.E993K|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	993					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCAATGGTTTCATCCAGACCT	0.502000													87	107					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451832	138451832	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138451832C>T	ENST00000344876.4	-	1	1797	c.1411G>A	c.(1411-1413)Gaa>Aaa	p.E471K	PCDH18_ENST00000412923.2_Missense_Mutation_p.E471K|PCDH18_ENST00000507846.1_Missense_Mutation_p.E251K|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	471	Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ATTACAAATTCATATCGGCTT	0.423000													66	185					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13752396	13752396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13752396G>A	ENST00000265104.4	-	64	10979	c.10875C>T	c.(10873-10875)atC>atT	p.I3625I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3625	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTAAAGACGTGATCTAGGAAC	0.423000									Kartagener syndrome				23	69					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214794828	214794828	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:214794828C>T	ENST00000331683.5	+	12	1454	c.1359C>T	c.(1357-1359)tcC>tcT	p.S453S	SPAG16_ENST00000374309.3_Silent_p.S359S	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	453					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TTGTGGCTTCCTCCTCACTGG	0.428000													53	84					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21028279	21028279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21028279C>T	ENST00000381545.3	+	9	1057	c.838C>T	c.(838-840)Ccg>Tcg	p.P280S	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.P280S|LST3_ENST00000540229.1_Missense_Mutation_p.P280S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.P280S|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	280					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TTTTTTCTTGCCGAAAAATCC	0.348000													24	84					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271775	59271775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59271775C>T	ENST00000313253.1	+	1	727	c.727C>T	c.(727-729)Cac>Tac	p.H243Y		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						TTGCACCTCCCACATCACTGT	0.552000													86	216					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166924631	166924631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:166924631G>A	ENST00000061240.2	+	6	1368	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	TLL1_ENST00000513213.1_Missense_Mutation_p.E241K|TLL1_ENST00000507499.1_Missense_Mutation_p.E241K	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	241	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGTTGTTCATGAATTGGGTCA	0.443000													36	96					0	0	1	0	0
ZNF2	7549	broad.mit.edu	37	2	95847143	95847143	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95847143C>T	ENST00000398107.2	+	4	966	c.444C>T	c.(442-444)acC>acT	p.T148T	ZNF2_ENST00000425369.1_Silent_p.T110T|ZNF2_ENST00000295210.6_Silent_p.T152T|ZNF2_ENST00000340539.5_Silent_p.T190T|ZNF2_ENST00000453539.2_Silent_p.T203T	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		CATCCCTCACCCGCCATCAGA	0.572000													22	94					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36271373	36271373	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36271373C>T	ENST00000296604.3	-	2	617	c.132G>A	c.(130-132)aaG>aaA	p.K44K	RANBP3L_ENST00000502994.1_Silent_p.K44K|RANBP3L_ENST00000515759.1_Silent_p.K44K	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	44					intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TTTGTTCTCCCTTTTCAAAAA	0.303000													10	69					0	0	1	0	0
DOK5	55816	broad.mit.edu	37	20	53205028	53205028	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:53205028G>A	ENST00000262593.5	+	3	531	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	DOK5_ENST00000395939.1_5'UTR	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	61	PH.						insulin receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			TCAGGTTACAGAACTCAATAA	0.408000													41	99					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36870251	36870251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36870251G>A	ENST00000279024.4	-	3	553	c.282C>T	c.(280-282)ccC>ccT	p.P94P		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	94										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GAGGGTTGAGGGGTGCCAAGT	0.572000													25	74					0	0	1	0	0
PSKH2	85481	broad.mit.edu	37	8	87076588	87076588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87076588C>T	ENST00000276616.2	-	2	532	c.458G>A	c.(457-459)gGa>gAa	p.G153E	PSKH2_ENST00000517981.1_5'UTR	NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	153	Protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			TGTAAAGGATCCCTGAGCAAT	0.488000													17	61					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33916036	33916036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33916036G>A	ENST00000389232.4	+	20	2456	c.2386G>A	c.(2386-2388)Gga>Aga	p.G796R	RYR3_ENST00000415757.3_Missense_Mutation_p.G796R	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	796	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGGACGTCATGGAGAGTTTAA	0.403000													12	103					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207640098	207640098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207640098G>A	ENST00000367057.3	+	2	475	c.286G>A	c.(286-288)Gta>Ata	p.V96I	CR2_ENST00000367059.3_Missense_Mutation_p.V96I|CR2_ENST00000458541.2_Missense_Mutation_p.V96I|CR2_ENST00000367058.3_Missense_Mutation_p.V96I	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	96	Sushi 2.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGAGCCCATAGTACCAGGAGG	0.398000													21	112					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633831	32633831	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32633831G>A	ENST00000242310.4	-	1	1836	c.1747C>T	c.(1747-1749)Cca>Tca	p.P583S	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	583					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGATTCCATGGATCTTTCACT	0.458000													117	261					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108872051	108872051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108872051C>T	ENST00000329106.2	+	4	423	c.423C>T	c.(421-423)ccC>ccT	p.P141P	SULT1C3_ENST00000376700.1_Silent_p.P141P	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	141						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						CCAGAAATCCCAAGGATTGCC	0.418000													49	111					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111964046	111964046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111964046G>A	ENST00000369732.3	-	8	810	c.755C>T	c.(754-756)cCc>cTc	p.P252L	OVGP1_ENST00000540696.1_Intron|OVGP1_ENST00000481495.1_5'UTR	NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	252					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		CTTCTCTGAGGGTGCCCCAAG	0.527000													27	92					0	0	1	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3391706	3391706	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:3391706C>T	ENST00000324266.5	+	2	507	c.312C>T	c.(310-312)ccC>ccT	p.P104P	TRAPPC12_ENST00000382110.2_Silent_p.P104P	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	104							binding										GCCCGGAGCCCGCGGGCACCC	0.771000													4	5					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142655514	142655514	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142655514C>T	ENST00000355265.2	-	5	876	c.400_splice	c.e5-1	p.E134_splice	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	134					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AATTCTGGACCTCTAGAAAGG	0.488000													12	39					0	0	1	0	0
P2RX5-TAX1BP3	100533970	broad.mit.edu	37	17	3594945	3594945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3594945G>A	ENST00000550383.1	-	2	469	c.281C>T	c.(280-282)cCa>cTa	p.P94L	P2RX5_ENST00000552050.1_Missense_Mutation_p.P58L|P2RX5_ENST00000435558.1_Missense_Mutation_p.P94L|P2RX5_ENST00000552276.1_Missense_Mutation_p.P94L|P2RX5_ENST00000225328.5_Missense_Mutation_p.P94L|P2RX5_ENST00000345901.3_Missense_Mutation_p.P94L|P2RX5_ENST00000547178.1_Missense_Mutation_p.P94L|P2RX5_ENST00000551178.1_Missense_Mutation_p.P94L																							GACCTGGGCTGGAATGACGTA	0.617000													22	37					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24811764	24811764	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24811764C>T	ENST00000221169.5	-	0	1694							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		TTTTAGGTATCGTGCCATTTC	0.378000													33	134					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200213792	200213792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:200213792C>T	ENST00000443023.1	-	6	2093	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	SATB2_ENST00000428695.1_Missense_Mutation_p.E151K|SATB2_ENST00000417098.1_Missense_Mutation_p.E269K|SATB2_ENST00000260926.5_Missense_Mutation_p.E269K|SATB2_ENST00000457245.1_Missense_Mutation_p.E269K			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	269						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GGAGACTGTTCGTTGGTTTTC	0.498000													30	63					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586118	20586118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20586118C>T	ENST00000315543.4	+	1	553	c.553C>T	c.(553-555)Ctt>Ttt	p.L185F		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTTGGGTCTCCTTCACTCAGG	0.448000													40	78					0	0	1	0	0
FOXO1	2308	broad.mit.edu	37	13	41134284	41134284	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:41134284A>C	ENST00000379561.5	-	2	1728	c.1344T>G	c.(1342-1344)agT>agG	p.S448R		NM_002015.3	NP_002006.2	Q12778	FOXO1_HUMAN	forkhead box O1	448					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX7/FOXO1(197)|PAX3/FOXO1(749)	central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	20		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TACCTCCATAACTCGACTTAT	0.453000													26	51					0	0	1	0	0
SLC9A8	23315	broad.mit.edu	37	20	48471989	48471989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:48471989C>T	ENST00000417961.1	+	8	842	c.632C>T	c.(631-633)tCc>tTc	p.S211F	SLC9A8_ENST00000541138.1_5'UTR|SLC9A8_ENST00000539601.1_5'UTR|SLC9A8_ENST00000361573.2_Missense_Mutation_p.S195F	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	195						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			GCGTTTGGCTCCCTAATATCT	0.438000													47	138					0	0	1	0	0
INA	9118	broad.mit.edu	37	10	105048321	105048321	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105048321G>T	ENST00000369849.4	+	3	1444	c.1395G>T	c.(1393-1395)caG>caT	p.Q465H		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	465	Tail.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		AAACCTCCCAGATAGGGGAAA	0.403000													6	76					0.0215528	0.0215557	1	1	0
LAMA1	284217	broad.mit.edu	37	18	7023190	7023190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:7023190C>T	ENST00000389658.3	-	19	2767	c.2674G>A	c.(2674-2676)Gac>Aac	p.D892N		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	892	Laminin EGF-like 8.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCACAGCGTCCCCATAGAAC	0.567000													10	22					0	0	1	0	0
DBNDD2	55861	broad.mit.edu	37	20	44037095	44037095	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44037095C>T	ENST00000372720.3	+	2	513	c.282C>T	c.(280-282)ccC>ccT	p.P94P	SYS1-DBNDD2_ENST00000475242.1_Intron|DBNDD2_ENST00000372723.3_Intron|DBNDD2_ENST00000360981.4_Intron|DBNDD2_ENST00000372710.3_Silent_p.P98P|DBNDD2_ENST00000372717.1_Intron|DBNDD2_ENST00000357275.2_Intron|DBNDD2_ENST00000372712.2_Intron|SYS1-DBNDD2_ENST00000452133.1_Intron|DBNDD2_ENST00000372722.3_Intron	NM_018478.3	NP_060948.3	Q9BQY9	DBND2_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 2	94					negative regulation of protein kinase activity	cytoplasm	protein binding			breast(1)|lung(2)	3		Myeloproliferative disorder(115;0.0122)				CTCCTCTACCCGCAGGAGCTG	0.602000													12	120					0	0	1	0	0
ZNF655	79027	broad.mit.edu	37	7	99171107	99171107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99171107C>T	ENST00000424881.1	+	4	1701	c.1481C>T	c.(1480-1482)aCc>aTc	p.T494I	ZNF655_ENST00000493277.1_Missense_Mutation_p.T494I|ZNF655_ENST00000394163.2_Missense_Mutation_p.T459I|ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000252713.4_Missense_Mutation_p.T459I	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	459					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GAAGTCCTCACCAGACAGAAA	0.403000													63	168					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532881	84532881	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84532881G>A	ENST00000527857.1	+	0	2903					NR_026851.1																						TATTTCTCAGGGAGATTCCAA	0.428000													9	17					0	0	1	0	0
MAGEB10	139422	broad.mit.edu	37	X	27840182	27840182	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27840182G>A	ENST00000356790.2	+	3	1004	c.759G>A	c.(757-759)gtG>gtA	p.V253V		NM_182506.3	NP_872312.2	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	253	MAGE.									NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	26						AAGATTTGGTGAAAGAAAATT	0.478000													5	26					0	0	1	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18123478	18123478	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:18123478C>T	ENST00000278816.2	+	2	824	c.174C>T	c.(172-174)tcC>tcT	p.S58S	CSRP2BP_ENST00000604915.1_Silent_p.S58S|CSRP2BP_ENST00000435364.2_Silent_p.S58S|PET117_ENST00000432901.2_3'UTR|CSRP2BP_ENST00000377681.2_Silent_p.S58S			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	58					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						GTGGGGATTCCCTCAACAGTG	0.527000													24	65					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600079	29600079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29600079C>T	ENST00000431530.3	+	1	1332	c.1274C>T	c.(1273-1275)tCa>tTa	p.S425L		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	415						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GGCAAAATTTCACCATGTGCA	0.507000													14	23					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56086338	56086338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56086338C>T	ENST00000312711.1	+	1	556	c.556C>T	c.(556-558)Cct>Tct	p.P186S		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					CCCTTTGTTACCTTTGCTTTG	0.328000													7	98					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69719813	69719813	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69719813C>T	ENST00000194900.4	+	18	2496	c.2155C>T	c.(2155-2157)Cag>Tag	p.Q719*	DLG3_ENST00000374360.3_Nonsense_Mutation_p.Q687*|DLG3_ENST00000542398.1_Nonsense_Mutation_p.Q236*|DLG3_ENST00000374355.3_Nonsense_Mutation_p.Q382*|DLG3_ENST00000461646.1_3'UTR			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	687	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					GAAAGATATTCAGGACAACAA	0.488000													9	14					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175063158	175063158	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175063158C>T	ENST00000239462.4	+	7	1470	c.1357C>T	c.(1357-1359)Cga>Tga	p.R453*		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	453	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGTCACTGATCGAGTGACTGA	0.433000													15	48					0	0	1	0	0
EVL	51466	broad.mit.edu	37	14	100563966	100563966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100563966C>T	ENST00000544450.2	+	3	624	c.341C>T	c.(340-342)gCc>gTc	p.A114V	EVL_ENST00000402714.2_Missense_Mutation_p.A108V|EVL_ENST00000392920.3_Missense_Mutation_p.A110V|EVL_ENST00000555048.1_3'UTR			Q9UI08	EVL_HUMAN	Enah/Vasp-like	108					actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				ATGCTGTTTGCCCTGAACATC	0.522000													10	69					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480344	140480344	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140480344G>A	ENST00000231130.2	+	1	111	c.111G>A	c.(109-111)gaG>gaA	p.E37E	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		37	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGTGGCTGAGGAAAAAGAGA	0.512000													7	59					0	0	1	0	0
ACVR1C	130399	broad.mit.edu	37	2	158443811	158443811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158443811G>A	ENST00000243349.7	-	2	552	c.192C>T	c.(190-192)gtC>gtT	p.V64V	ACVR1C_ENST00000335450.7_Silent_p.V64V|ACVR1C_ENST00000348328.5_Silent_p.V64V|ACVR1C_ENST00000409680.3_Silent_p.V14V	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	64					apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						CTGGAAGGGAGACACAGGATT	0.423000													98	264					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31235609	31235609	+	Missense_Mutation	SNP	G	G	A	rs112486041		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31235609G>A	ENST00000322122.3	+	7	1251	c.967G>A	c.(967-969)Gag>Aag	p.E323K		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	323	B30.2/SPRY.				exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						GCCGGCCGGGGAGGACCCGCG	0.706000													9	20					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235236	5235236	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:5235236G>A	ENST00000274181.7	+	13	2098	c.1960G>A	c.(1960-1962)Gag>Aag	p.E654K	ADAMTS16_ENST00000513709.1_3'UTR	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	654	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TCAGTGTGCCGAGCACAACAG	0.527000													23	63					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46903410	46903410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:46903410C>T	ENST00000378623.1	-	20	2899	c.2657G>A	c.(2656-2658)cGa>cAa	p.R886Q		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	886					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CATGCCAGCTCGTTCAATCTT	0.512000													6	41					0	0	1	0	0
ZNF480	147657	broad.mit.edu	37	19	52825349	52825349	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52825349C>T	ENST00000595962.1	+	5	912	c.846C>T	c.(844-846)acC>acT	p.T282T	ZNF480_ENST00000490272.1_3'UTR|ZNF480_ENST00000335090.6_Silent_p.T205T|CTD-2525I3.6_ENST00000594379.1_RNA|ZNF480_ENST00000334564.7_Silent_p.T239T	NM_144684.2	NP_653285.2	Q8WV37	ZN480_HUMAN	zinc finger protein 480	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		GAATTCATACCAGAGAGAAGC	0.348000													14	44					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50223468	50223468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50223468C>T	ENST00000284509.6	-	16	1631	c.1490G>A	c.(1489-1491)gGg>gAg	p.G497E	ATP8B4_ENST00000559829.1_Missense_Mutation_p.G497E	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	497					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CACTAGAGCCCCTTCATCAGG	0.393000													11	49					0	0	1	0	0
DPPA3	359787	broad.mit.edu	37	12	7867834	7867834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7867834C>T	ENST00000345088.2	+	2	255	c.138C>T	c.(136-138)atC>atT	p.I46I		NM_199286.2	NP_954980.1	Q6W0C5	DPPA3_HUMAN	developmental pluripotency associated 3	46						cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)	8				Kidney(36;0.0887)		ACTTGACTATCAACGCTAGTA	0.458000													14	102					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142176561	142176561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142176561G>A	ENST00000350721.4	-	45	7661	c.7540C>T	c.(7540-7542)Cgc>Tgc	p.R2514C	ATR_ENST00000383101.3_Missense_Mutation_p.R2450C	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2514	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TGAGTCAGGCGAAATGGCACA	0.368000								Other conserved DNA damage response genes					28	63					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54780682	54780682	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54780682G>A	ENST00000391748.1	-	10	1586	c.1459C>T	c.(1459-1461)Cag>Tag	p.Q487*	LILRB2_ENST00000434421.1_Nonsense_Mutation_p.Q372*|LILRB2_ENST00000391746.1_Nonsense_Mutation_p.Q488*|LILRB2_ENST00000314446.5_Nonsense_Mutation_p.Q487*|LILRB2_ENST00000391749.4_Nonsense_Mutation_p.Q488*	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	488					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGTTTGCCCTGACGTCGATGT	0.607000													33	175					0	0	1	0	0
ANKRD22	118932	broad.mit.edu	37	10	90588376	90588376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90588376G>A	ENST00000371930.4	-	3	471	c.261C>T	c.(259-261)ttC>ttT	p.F87F		NM_144590.2	NP_653191.2	Q5VYY1	ANR22_HUMAN	ankyrin repeat domain 22	87										NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10		Colorectal(252;0.0163)		Colorectal(12;6.29e-05)|COAD - Colon adenocarcinoma(12;7.69e-05)		GATAATCAATGAAGGTAAATT	0.323000													50	120					0	0	1	0	0
SLAMF8	56833	broad.mit.edu	37	1	159799809	159799809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159799809G>A	ENST00000289707.5	+	2	343	c.194G>A	c.(193-195)cGa>cAa	p.R65Q	SLAMF8_ENST00000368104.4_Intron|SLAMF8_ENST00000471286.1_3'UTR	NM_020125.2	NP_064510.1	Q9P0V8	SLAF8_HUMAN	SLAM family member 8	65						integral to membrane				endometrium(2)|large_intestine(4)|lung(6)	12	all_hematologic(112;0.0597)					ACGTTTTTCCGAGGCTCCCTG	0.637000													80	159					0	0	1	0	0
RNASE3	6037	broad.mit.edu	37	14	21359980	21359980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21359980G>A	ENST00000304639.3	+	2	193	c.135G>A	c.(133-135)ctG>ctA	p.L45L		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	45					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	ACATCAGTCTGAACCCCCCTC	0.488000													49	118					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569441	179569441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179569441C>T	ENST00000589042.1	-	105	29982	c.29758G>A	c.(29758-29760)Gaa>Aaa	p.E9920K	TTN_ENST00000342992.6_Missense_Mutation_p.E8676K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E9603K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9603	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTCAATTTCAAAGACAGCA	0.328000													10	15					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70331697	70331697	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70331697G>A	ENST00000338508.4	-	32	4703	c.4704C>T	c.(4702-4704)ctC>ctT	p.L1568L	SHANK2_ENST00000449833.2_Silent_p.L972L|SHANK2_ENST00000423696.2_Silent_p.L1188L|SHANK2_ENST00000409161.1_Silent_p.L971L			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1188					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTTCTTCCACGAGCGCGTCTT	0.552000													61	172					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699242	43699242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43699242G>A	ENST00000405312.3	-	4	1130	c.893C>T	c.(892-894)cCc>cTc	p.P298L	PSG4_ENST00000433626.2_Missense_Mutation_p.P205L|PSG4_ENST00000244295.9_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	298	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				CGTGACATTGGGTAGAATGAG	0.483000													68	274					0	0	1	0	0
FXYD5	53827	broad.mit.edu	37	19	35657304	35657304	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35657304G>A	ENST00000543307.1	+	8	643	c.563G>A	c.(562-564)gGt>gAt	p.G188D	FXYD5_ENST00000392217.3_Intron|FXYD5_ENST00000342879.3_Intron|FXYD5_ENST00000590686.1_Intron|FXYD5_ENST00000588699.1_Missense_Mutation_p.G188D|FXYD5_ENST00000591716.2_Intron|FXYD5_ENST00000541435.2_Intron|FXYD5_ENST00000423817.3_Intron|FXYD5_ENST00000392219.2_Intron			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	0					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GTTCTCAAAGGTCCCTGGGCA	0.453000													5	49					0	0	1	0	0
OGT	8473	broad.mit.edu	37	X	70764432	70764432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70764432C>T	ENST00000373719.3	+	4	695	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	OGT_ENST00000373701.3_Missense_Mutation_p.R150C|OGT_ENST00000498566.1_3'UTR	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	160					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					GTACTGTGTTCGCAGTGACCT	0.398000													3	15					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104129725	104129725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104129725C>T	ENST00000369983.3	+	26	3580	c.3320C>T	c.(3319-3321)gCc>gTc	p.A1107V		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1107					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AAGAGAGTGGCCTTAGAGTGT	0.483000													27	58					0	0	1	0	0
USB1	79650	broad.mit.edu	37	16	58044008	58044008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58044008C>T	ENST00000219281.3	+	3	552	c.441C>T	c.(439-441)tcC>tcT	p.S147S	USB1_ENST00000561743.1_Silent_p.S96S|USB1_ENST00000423271.3_Silent_p.S147S|USB1_ENST00000565662.1_3'UTR|USB1_ENST00000563149.1_Silent_p.S147S|USB1_ENST00000539737.2_Silent_p.S147S	NM_024598.3	NP_078874.2			U6 snRNA biogenesis 1																		GTATGACCTCCTTCCACAGGT	0.597000													6	48					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70500891	70500891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70500891C>T	ENST00000428974.2	+	5	525	c.467C>T	c.(466-468)tCg>tTg	p.S156L	FUK_ENST00000571514.1_Intron|FUK_ENST00000288078.6_Intron|FUK_ENST00000378912.2_Intron			Q8N0W3	FUK_HUMAN	fucokinase	612						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				TGCCTTCCTTCGTCACAGCCA	0.637000													10	30					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12661513	12661513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12661513G>A	ENST00000425538.1	+	12	2514	c.2314G>A	c.(2314-2316)Gaa>Aaa	p.E772K	MYOCD_ENST00000395988.1_Missense_Mutation_p.E676K|MYOCD_ENST00000343344.4_Missense_Mutation_p.E724K	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	724					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCCATCCTATGAAGATGCCGT	0.393000													21	36					0	0	1	0	0
CH25H	9023	broad.mit.edu	37	10	90966983	90966983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90966983G>A	ENST00000371852.2	-	1	88	c.67C>T	c.(67-69)Ctc>Ttc	p.L23F		NM_003956.3	NP_003947.1	O95992	CH25H_HUMAN	cholesterol 25-hydroxylase	23					bile acid biosynthetic process|fatty acid biosynthetic process|sterol biosynthetic process	cytosol|endoplasmic reticulum membrane|integral to membrane	cholesterol 25-hydroxylase activity|iron ion binding			kidney(1)|large_intestine(2)|lung(3)|stomach(1)	7		Colorectal(252;0.0161)		GBM - Glioblastoma multiforme(2;0.000133)		TGGTCCCAGAGGGGCTGCAGG	0.627000													6	6					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28861654	28861654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28861654C>T	ENST00000373833.6	+	8	819	c.534C>T	c.(532-534)gcC>gcT	p.A178A	RCC1_ENST00000429051.1_3'UTR|RCC1_ENST00000373831.3_Silent_p.A209A|RCC1_ENST00000373832.1_Silent_p.A178A|RCC1_ENST00000398958.2_Silent_p.A178A			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	178					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		TAAAGGTGGCCTCAGGTGGGT	0.577000													17	69					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105965741	105965741	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105965741C>T	ENST00000357060.3	-	7	1058	c.943G>A	c.(943-945)Ggc>Agc	p.G315S	WDR96_ENST00000428666.1_Missense_Mutation_p.G316S|WDR96_ENST00000278064.2_Missense_Mutation_p.G246S|WDR96_ENST00000369719.1_Missense_Mutation_p.G246S|WDR96_ENST00000369720.1_Missense_Mutation_p.G246S	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	315										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GCCAGCACGCCCTCCTTCTGA	0.338000													12	47					0	0	1	0	0
STOML1	9399	broad.mit.edu	37	15	74281509	74281509	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74281509G>A	ENST00000316900.5	-	3	454	c.330C>T	c.(328-330)ttC>ttT	p.F110F	STOML1_ENST00000564777.1_Intron|STOML1_ENST00000359750.4_Silent_p.F110F|STOML1_ENST00000541638.1_Silent_p.F68F|STOML1_ENST00000316911.6_Intron|STOML1_ENST00000561656.1_Silent_p.F23F	NM_001256672.1|NM_001256675.1|NM_001256677.1|NM_004809.4	NP_001243601.1|NP_001243604.1|NP_001243606.1|NP_004800.2	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	110						integral to membrane	sterol binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						AGGAGTCAATGAAGGGCAAGA	0.597000													25	57					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35144355	35144355	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:35144355C>T	ENST00000436258.1	-	0	1711																											ACGCTAACAACTGCAATGTGT	0.323000													9	34					0	0	1	0	0
MGEA5	10724	broad.mit.edu	37	10	103550824	103550824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103550824G>A	ENST00000361464.3	-	14	2678	c.2283C>T	c.(2281-2283)tcC>tcT	p.S761S	MGEA5_ENST00000482611.1_5'UTR|MGEA5_ENST00000357797.5_Silent_p.S694S|MGEA5_ENST00000439817.1_Silent_p.S708S	NM_012215.3	NP_036347.1	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	761	Histone acetyltransferase activity (By similarity).|Required for histone H4 binding (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	23		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		CCAGGCTGAGGGAAAGCAGCC	0.423000													37	73					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20999045	20999045	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20999045C>T	ENST00000261383.3	-	46	6851	c.6852G>A	c.(6850-6852)ggG>ggA	p.G2284G	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2284	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACAGCAGGACCCCTTGAATCA	0.453000													12	46					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20636757	20636757	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20636757C>T	ENST00000219151.4	-	12	1678	c.468G>A	c.(466-468)ccG>ccA	p.P156P	ACSM1_ENST00000520010.1_Silent_p.P505P|ACSM1_ENST00000307493.4_Silent_p.P505P			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	505					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding	p.P505P(2)|p.P156P(2)		central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						CCCCTCGAATCGGGTCTGGGC	0.602000													19	16					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24880576	24880576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24880576G>A	ENST00000382554.3	+	6	2880	c.2562G>A	c.(2560-2562)acG>acA	p.T854T		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	854					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						ACTTTCTGACGAAGCTACACT	0.552000											OREG0022626	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	95	185					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23890862	23890862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23890862C>T	ENST00000532292.1	-	1	313	c.219G>A	c.(217-219)gaG>gaA	p.E73E		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GTGTGGGCACCTCCGCTTGCG	0.682000													4	11					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349741	100349741	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100349741C>T	ENST00000542585.1	+	0	2161				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCACCACCTCCATGGAAGAGC	0.522000													25	69					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55449572	55449572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55449572C>T	ENST00000446217.1	-	7	2455	c.2053G>A	c.(2053-2055)Gat>Aat	p.D685N	NLRP7_ENST00000592784.1_Missense_Mutation_p.D657N|NLRP7_ENST00000340844.2_Missense_Mutation_p.D657N|NLRP7_ENST00000588756.1_Missense_Mutation_p.D657N|NLRP7_ENST00000448121.2_Intron|NLRP7_ENST00000328092.5_Intron|NLRP7_ENST00000590030.1_Missense_Mutation_p.D657N			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	657							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GAGCGAAGATCCTGCCGAGCC	0.502000													35	81					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	40068723	40068723	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40068723C>T	ENST00000350221.3	-	2	212	c.3G>A	c.(1-3)atG>atA	p.M1I	RP11-37C7.1_ENST00000558616.1_RNA	NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	1										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		TTATAATATCCATTGAAATCC	0.338000													30	78					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3122903	3122903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3122903G>A	ENST00000263650.7	-	13	1611	c.1452C>T	c.(1450-1452)gcC>gcT	p.A484A	OSBPL5_ENST00000389989.3_Silent_p.A416A|OSBPL5_ENST00000348039.5_Silent_p.A416A|OSBPL5_ENST00000525498.1_Silent_p.A395A|OSBPL5_ENST00000542243.1_Silent_p.A115A	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	484					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TGACGTGGAAGGCAGACACGG	0.637000													17	41					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59728228	59728228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:59728228G>A	ENST00000361421.1	-	7	1281	c.1061C>T	c.(1060-1062)tCg>tTg	p.S354L		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	354						nucleus	DNA binding	p.S354L(2)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				CGACGGCTTCGAATTGATCAG	0.522000													14	52					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115391684	115391684	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115391684C>A	ENST00000369358.4	-	17	1916	c.1672G>T	c.(1672-1674)Gga>Tga	p.G558*	NRAP_ENST00000360478.3_Nonsense_Mutation_p.G523*|NRAP_ENST00000369360.3_Nonsense_Mutation_p.G523*|NRAP_ENST00000359988.3_Nonsense_Mutation_p.G558*			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	558						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ATCTCAAATCCTTTCCCCTTT	0.463000													48	147					1.46156e-29	1.47155e-29	1	1	0
CNGA2	1260	broad.mit.edu	37	X	150907031	150907031	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150907031G>A	ENST00000329903.4	+	1	109	c.76G>A	c.(76-78)Gcc>Acc	p.A26T		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	26					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					TGCCATCAAGGCCAATGGCAA	0.502000													43	33					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7416873	7416873	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7416873C>T	ENST00000322644.6	+	29	5689	c.5290C>T	c.(5290-5292)Ccg>Tcg	p.P1764S		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1764	52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				CAGCTACAGCCCGACATCACC	0.542000													121	205					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10951376	10951376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10951376G>A	ENST00000298232.7	-	9	649	c.282C>T	c.(280-282)gaC>gaT	p.D94D	TPTE_ENST00000361285.4_Silent_p.D112D|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.D74D	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	112					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAAAATTAGGTCGGCAAGGA	0.323000													20	197					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149509438	149509438	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149509438C>T	ENST00000261799.4	-	10	1930	c.1461G>A	c.(1459-1461)caG>caA	p.Q487Q		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	487	Ig-like C2-type 5.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCTCAAACTCCTGCTCCTCCT	0.647000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""						OREG0016927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	67					0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48429349	48429349	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48429349C>T	ENST00000224605.2	-	2	802	c.537G>A	c.(535-537)caG>caA	p.Q179Q		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	179					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						TGGCCGTGTTCTGCGAGAGGC	0.721000													4	28					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41758873	41758873	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41758873G>A	ENST00000301178.4	+	16	2116		c.e16+1		AXL_ENST00000593513.1_Splice_Site|AXL_ENST00000359092.3_Splice_Site	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase							integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						CCAGCCAGTGGTAAGGGGCGT	0.517000													16	65					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234750088	234750088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234750088G>A	ENST00000411486.2	-	8	1403	c.1338C>T	c.(1336-1338)tgC>tgT	p.C446C	HJURP_ENST00000432087.1_Silent_p.C392C|HJURP_ENST00000441687.1_Silent_p.C361C	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	446					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		TGGGACTCAGGCAATATTCCC	0.547000													33	112					0	0	1	0	0
GEM	2669	broad.mit.edu	37	8	95265325	95265325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:95265325C>T	ENST00000297596.2	-	3	611	c.347G>A	c.(346-348)cGa>cAa	p.R116Q	GEM_ENST00000396194.2_Missense_Mutation_p.R116Q	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	116					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			CATCAGGGTTCGTTCATATGT	0.413000													42	87					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96701966	96701966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96701966G>A	ENST00000260682.6	+	3	361	c.349G>A	c.(349-351)Gga>Aga	p.G117R	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	117					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TTTCAGCAATGGAAAGAAATG	0.522000													35	69					0	0	1	0	0
CEACAM16	388551	broad.mit.edu	37	19	45211365	45211365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45211365G>A	ENST00000587331.1	+	6	1388	c.1173G>A	c.(1171-1173)caG>caA	p.Q391Q	CEACAM16_ENST00000405314.2_Silent_p.Q391Q|CTB-171A8.1_ENST00000590796.1_RNA	NM_001039213.2	NP_001034302.2	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 16	391										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				TGTTGGTGCAGAAGCTGAACC	0.632000													10	10					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48465262	48465262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48465262G>A	ENST00000358536.4	-	3	1028	c.759C>T	c.(757-759)ctC>ctT	p.L253L	PLXNB1_ENST00000456774.1_Silent_p.L253L|PLXNB1_ENST00000296440.6_Silent_p.L253L|PLXNB1_ENST00000358459.4_Silent_p.L253L|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	253	Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTGGTCCCGGAGACACACTC	0.622000													17	82					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102851526	102851526	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102851526G>A	ENST00000264257.2	+	11	1593	c.1467G>A	c.(1465-1467)gaG>gaA	p.E489E	IL1RL2_ENST00000539491.1_Silent_p.E489E|IL1RL2_ENST00000441515.2_Silent_p.E371E|IL1RL2_ENST00000481806.1_3'UTR	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	489	TIR.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						TTGAGCTGGAGAAAATCGAGG	0.512000													33	87					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83350314	83350314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83350314G>A	ENST00000261722.3	-	5	586	c.379C>T	c.(379-381)Cgt>Tgt	p.R127C	AP3B2_ENST00000535359.1_Missense_Mutation_p.R127C|RP11-752G15.3_ENST00000560650.1_RNA|AP3B2_ENST00000535348.1_Missense_Mutation_p.R95C	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	127					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			GCACTGGCACGAATCAGCTGG	0.572000													20	66					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11684402	11684402	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11684402C>T	ENST00000262442.3	+	39	7697	c.7629C>T	c.(7627-7629)ttC>ttT	p.F2543F	DNAH9_ENST00000454412.2_Silent_p.F2543F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2543	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCATCTATTTCATTGATGACA	0.557000													13	26					0	0	1	0	0
LINC00477	144360	broad.mit.edu	37	12	24736816	24736816	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:24736816G>A	ENST00000483544.1	-	0	286					NR_029451.2																						CCTAGGAAACGAAGTAAAAAG	0.527000													8	65					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	14018946	14018946	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14018946G>A	ENST00000279593.3	-	2	406	c.197C>T	c.(196-198)cCc>cTc	p.P66L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	66					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTCCACCCGGGGTACCACGGA	0.557000													26	99					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8136997	8136997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8136997C>T	ENST00000600128.1	-	63	8437	c.8023G>A	c.(8023-8025)Gaa>Aaa	p.E2675K	FBN3_ENST00000601739.1_Missense_Mutation_p.E2675K|FBN3_ENST00000270509.2_Missense_Mutation_p.E2675K			Q75N90	FBN3_HUMAN	fibrillin 3	2675						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ATCTTGCATTCGTAGCAGGCT	0.662000													63	147					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117243236	117243236	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117243236G>A	ENST00000332958.2	+	13	1375	c.1359G>A	c.(1357-1359)aaG>aaA	p.K453K		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	453					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						AAGAACTGAAGGATCTCCTTA	0.353000													14	58					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167525034	167525034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167525034C>T	ENST00000519204.1	+	8	1470	c.1352C>T	c.(1351-1353)tCa>tTa	p.S451L	TENM2_ENST00000403607.2_Missense_Mutation_p.S405L|TENM2_ENST00000545108.1_Missense_Mutation_p.S572L|TENM2_ENST00000518659.1_Missense_Mutation_p.S572L|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000520394.1_Missense_Mutation_p.S340L					teneurin transmembrane protein 2																		TTTTCAGATTCAGTGCAGGAC	0.448000													6	21					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72723336	72723336	+	Missense_Mutation	SNP	G	G	A	rs140390474		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72723336G>A	ENST00000377182.4	+	3	975	c.358G>A	c.(358-360)Gaa>Aaa	p.E120K	MAMDC2-AS1_ENST00000591368.1_RNA|MAMDC2-AS1_ENST00000414515.3_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	120	MAM 1.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						GTCAGCTAAGGAACCTTCAGA	0.438000													18	54					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54956501	54956501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54956501C>T	ENST00000173898.7	+	12	3456	c.3344C>T	c.(3343-3345)aCc>aTc	p.T1115I	TRO_ENST00000319167.8_Intron|TRO_ENST00000420798.2_Missense_Mutation_p.T646I|TRO_ENST00000375041.2_Missense_Mutation_p.T718I|TRO_ENST00000399736.1_Intron|TRO_ENST00000375022.4_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	1115	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GCACTTAGTACCGCTGCTGAC	0.582000													33	13					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84526469	84526469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84526469C>T	ENST00000360700.4	+	10	2945	c.2059C>T	c.(2059-2061)Cat>Tat	p.H687Y	ZNF711_ENST00000542798.1_Missense_Mutation_p.H483Y|ZNF711_ENST00000373165.3_Missense_Mutation_p.H641Y|ZNF711_ENST00000276123.3_Missense_Mutation_p.H641Y|ZNF711_ENST00000395402.1_Missense_Mutation_p.H649Y			Q9Y462	ZN711_HUMAN	zinc finger protein 711	641					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TAGTGATATCCATAAGGGTAG	0.388000													17	14					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	123987692	123987692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123987692G>A	ENST00000360013.3	+	5	680	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	KALRN_ENST00000240874.3_Missense_Mutation_p.E185K|KALRN_ENST00000460856.1_Missense_Mutation_p.E185K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	185					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GGAGTGGATCGAACTGCGGCT	0.602000													18	48					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	825075	825075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:825075C>T	ENST00000293892.3	-	7	1496	c.1497G>A	c.(1495-1497)cgG>cgA	p.R499R	MSLNL_ENST00000442466.1_Intron			Q96KJ4	MSLNL_HUMAN	mesothelin-like	168					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CTCCAATGCACCGGGCCCATC	0.761000													6	18					0	0	1	0	0
ZC3H15	55854	broad.mit.edu	37	2	187370268	187370268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:187370268C>T	ENST00000337859.6	+	7	1035	c.808C>T	c.(808-810)Ctt>Ttt	p.L270F	ZC3H15_ENST00000544130.1_Missense_Mutation_p.L65F	NM_018471.2	NP_060941.2	Q8WU90	ZC3HF_HUMAN	zinc finger CCCH-type containing 15	270						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			GATTGATAAACTTGAACAAGA	0.393000													11	60					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2217878	2217878	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2217878C>T	ENST00000398665.3	+	22	2688	c.2652C>T	c.(2650-2652)ccC>ccT	p.P884P		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	884						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGCATTCCCCTGGCCAGCG	0.687000													6	27					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232941806	232941806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:232941806G>A	ENST00000418460.1	+	1	1164	c.1037G>A	c.(1036-1038)gGa>gAa	p.G346E		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		ACAGGAGGAGGAGCGGAGGTC	0.632000													15	39					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158596730	158596730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158596730G>A	ENST00000368148.3	-	41	5912	c.5732C>T	c.(5731-5733)cCt>cTt	p.P1911L	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Missense_Mutation_p.P1908L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1911					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGCCAGAGAAGGGGTCTTTTC	0.428000													63	149					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178556956	178556956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178556956G>A	ENST00000251582.7	-	16	2535	c.2434C>T	c.(2434-2436)Ctc>Ttc	p.L812F		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	812	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GTGCCGTGGAGGGGGCCCATG	0.657000													22	55					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32260977	32260977	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32260977C>T	ENST00000375015.4	-	26	1670	c.1470G>A	c.(1468-1470)gaG>gaA	p.E490E	C6orf10_ENST00000442822.2_Intron|C6orf10_ENST00000527965.1_Silent_p.E475E|C6orf10_ENST00000375007.4_Silent_p.E489E|C6orf10_ENST00000533191.1_Silent_p.E489E|C6orf10_ENST00000447241.2_Silent_p.E491E			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	491	Lys-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						CCTCAAAACTCTCCTTCTTTT	0.373000													13	227					0	0	1	0	0
AGPAT2	10555	broad.mit.edu	37	9	139571924	139571924	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139571924G>A	ENST00000371696.2	-	2	332	c.267C>T	c.(265-267)gcC>gcT	p.A89A	AGPAT2_ENST00000371694.3_Silent_p.A89A|AGPAT2_ENST00000538402.1_Silent_p.A89A	NM_006412.3	NP_006403.2	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	89					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			endometrium(1)|large_intestine(1)|lung(2)|prostate(2)	6	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		CACAGGGACGGGCCTCCTGCA	0.652000													19	51					0	0	1	0	0
PHOX2A	401	broad.mit.edu	37	11	71950911	71950911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71950911C>T	ENST00000298231.5	-	3	908	c.737G>A	c.(736-738)gGa>gAa	p.G246E	PHOX2A_ENST00000544057.1_5'UTR	NM_005169.3	NP_005160.2	O14813	PHX2A_HUMAN	paired-like homeobox 2a	246	Poly-Gly.				noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	5						TTCGGCCGCTCCCGCGCCAGG	0.771000													3	2					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233150519	233150519	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233150519G>A	ENST00000258229.8	-	28	5078	c.4844C>T	c.(4843-4845)tCa>tTa	p.S1615L	PCNXL2_ENST00000344698.2_Missense_Mutation_p.S267L	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1615						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CAGGGTCGTTGAAGGCTGAAA	0.502000													16	51					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63149733	63149733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63149733C>T	ENST00000279178.3	+	6	1306	c.1057C>T	c.(1057-1059)Ctc>Ttc	p.L353F	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	353					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						AAGGATCTCCCTCCTGTCCTT	0.403000													40	107					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394038	233394038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233394038C>T	ENST00000258229.8	-	5	1804	c.1570G>A	c.(1570-1572)Gaa>Aaa	p.E524K	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	524						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TGCCTCTTTTCATGGCTGGAC	0.502000													19	50					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227924928	227924928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227924928G>A	ENST00000396625.3	-	27	2295	c.2088C>T	c.(2086-2088)gcC>gcT	p.A696A	COL4A4_ENST00000329662.7_Silent_p.A696A	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	696	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCAGCCCAGGGGCACCTTGGG	0.428000													50	107					0	0	1	0	0
PLBD1	79887	broad.mit.edu	37	12	14706282	14706282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14706282C>T	ENST00000240617.5	-	2	832	c.180G>A	c.(178-180)atG>atA	p.M60I		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	60					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						CATTCTTGTCCATTACATTTT	0.448000													18	98					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018525	161018525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161018525C>T	ENST00000368013.3	-	12	2606	c.2286G>A	c.(2284-2286)caG>caA	p.Q762Q	ARHGAP30_ENST00000368015.1_Silent_p.Q585Q|ARHGAP30_ENST00000368016.3_Intron	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	762	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CAGCTTCTACCTGGGCTTCCT	0.488000													38	304					0	0	1	0	0
SHBG	6462	broad.mit.edu	37	17	7534655	7534655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7534655C>T	ENST00000380450.4	+	4	562	c.531C>T	c.(529-531)ttC>ttT	p.F177F	SHBG_ENST00000572262.1_Intron|SHBG_ENST00000572182.1_Intron|SHBG_ENST00000576728.1_Intron|SHBG_ENST00000340624.5_Silent_p.F119F|SHBG_ENST00000576478.1_Intron|SHBG_ENST00000574539.1_Silent_p.F119F|SHBG_ENST00000416273.3_Silent_p.F177F|SHBG_ENST00000441599.2_Silent_p.F177F|SHBG_ENST00000575314.1_Silent_p.F119F|SHBG_ENST00000575903.1_Silent_p.F177F|SHBG_ENST00000570547.1_Silent_p.F119F	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin	177	Laminin G-like 1.				hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	GGCTGCTCTTCCCCGCTTCCA	0.612000													8	15					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149227596	149227596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:149227596C>T	ENST00000407073.1	+	9	3081	c.2084C>T	c.(2083-2085)tCa>tTa	p.S695L	MBD5_ENST00000404807.1_Missense_Mutation_p.S695L	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	695						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GGTCAGGGTTCATTTCCCATC	0.468000													24	64					0	0	1	0	0
C2	717	broad.mit.edu	37	6	31902026	31902026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31902026G>A	ENST00000299367.5	+	6	1075	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	CFB_ENST00000477310.1_Intron|CFB_ENST00000456570.1_Intron|C2_ENST00000442278.2_Missense_Mutation_p.E135K|C2_ENST00000452323.2_Intron|C2_ENST00000469372.1_Intron|CFB_ENST00000556679.1_Intron|C2_ENST00000418949.2_Missense_Mutation_p.E267K	NM_000063.4	NP_000054.2			complement component 2											haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	27		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		GAGTGTGTCGGAAAATGACTT	0.532000													66	241					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167298029	167298029	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167298029G>A	ENST00000409855.1	-	14	2160	c.2034C>T	c.(2032-2034)ttC>ttT	p.F678F		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	678					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						ACACATTCAGGAAGGAGTGGA	0.463000													20	51					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89653337	89653337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89653337C>T	ENST00000264344.5	-	22	2866	c.2659G>A	c.(2659-2661)Ggg>Agg	p.G887R	FAM13A_ENST00000503556.1_Missense_Mutation_p.G547R|FAM13A_ENST00000513837.1_Missense_Mutation_p.G533R|FAM13A_ENST00000511976.1_Missense_Mutation_p.G473R|FAM13A_ENST00000508369.1_Missense_Mutation_p.G561R|FAM13A_ENST00000395002.2_Missense_Mutation_p.G533R	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	887					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TCTTCTGACCCCTCCTCTTCT	0.413000													30	60					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19758545	19758545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19758545G>A	ENST00000357324.6	-	20	2682	c.2656C>T	c.(2656-2658)Cct>Tct	p.P886S	ATP13A1_ENST00000291503.5_Missense_Mutation_p.P768S	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	886					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						ACCCGCTCAGGGGCATTGGCC	0.682000													4	6					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27683082	27683082	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27683082G>A	ENST00000493901.1	-	26	3762	c.3524_splice	c.e26+1	p.R1175_splice	MAP3K6_ENST00000357582.2_Splice_Site_p.R1175_splice|MAP3K6_ENST00000374040.3_Splice_Site_p.R1167_splice	NM_004672.3	NP_004663.3	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	1175					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GGGCTTTACCGATCAGTCTCT	0.642000													13	24					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211163161	211163161	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211163161C>T	ENST00000352451.3	-	3	434	c.287G>A	c.(286-288)gGa>gAa	p.G96E	MYL1_ENST00000341685.4_Missense_Mutation_p.G52E|MYL1_ENST00000496436.1_5'UTR	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	96					muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GCTGGGGTTTCCCAGAACTTT	0.483000													39	129					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131924381	131924381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131924381C>T	ENST00000378823.3	+	8	1455	c.637C>T	c.(637-639)Cgt>Tgt	p.R213C	RAD50_ENST00000265335.6_Missense_Mutation_p.R352C|RAD50_ENST00000487596.1_3'UTR	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	352					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTTAAAAGGTCGTCTACAGCT	0.368000								Homologous recombination					33	25					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149506170	149506170	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149506170G>A	ENST00000261799.4	-	11	2056	c.1587C>T	c.(1585-1587)ccC>ccT	p.P529P		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	529					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCACCTTAAAGGGCAAGGCTG	0.562000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								5	38					0	0	1	0	0
KRTAP10-12	386685	broad.mit.edu	37	21	46117708	46117708	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46117708C>T	ENST00000400365.3	+	1	622	c.592C>T	c.(592-594)Ctc>Ttc	p.L198F	TSPEAR_ENST00000323084.4_Intron	NM_198699.1	NP_941972.1	P60413	KR10C_HUMAN	keratin associated protein 10-12	198	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|lung(8)	9						CGTGTCCCTCCTCTGCCGCCC	0.701000													50	179					0	0	1	0	0
KLK13	26085	broad.mit.edu	37	19	51563821	51563821	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51563821G>A	ENST00000595793.1	-	2	150	c.108C>T	c.(106-108)ctC>ctT	p.L36L	KLK13_ENST00000596955.1_Silent_p.L36L|KLK13_ENST00000595547.1_Silent_p.L36L|KLK13_ENST00000335422.3_Intron	NM_015596.1	NP_056411.1	Q9UKR3	KLK13_HUMAN	kallikrein-related peptidase 13	36	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|skin(1)	16		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		AGCCACCTGGGAGAAACCCAC	0.572000													53	89					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19766141	19766141	+	Silent	SNP	G	G	A	rs117174741	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19766141G>A	ENST00000357324.6	-	11	1544	c.1518C>T	c.(1516-1518)atC>atT	p.I506I	ATP13A1_ENST00000291503.5_Silent_p.I388I|ATP13A1_ENST00000496082.1_5'UTR	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	506					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						TGGCCAGGGCGATGAGGGAGG	0.627000													17	50					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109865299	109865299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109865299G>A	ENST00000310903.5	+	19	1915	c.1809G>A	c.(1807-1809)agG>agA	p.R603R	MYO1H_ENST00000431443.2_Silent_p.R613R			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						TCCTCATAAGGCATCAGATCA	0.463000													69	177					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58978287	58978287	+	Silent	SNP	C	C	T	rs144610063		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58978287C>T	ENST00000361050.3	-	1	2137	c.2052G>A	c.(2050-2052)aaG>aaA	p.K684K		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	684						integral to membrane		p.K684K(1)		NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GATATGCTTTCTTCTTGAACT	0.542000													28	84					0	0	1	0	0
FOXP4	116113	broad.mit.edu	37	6	41558063	41558063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41558063C>T	ENST00000373060.1	+	12	1870	c.1412C>T	c.(1411-1413)aCc>aTc	p.T471I	FOXP4_ENST00000409208.1_Missense_Mutation_p.T459I|FOXP4_ENST00000373063.3_Missense_Mutation_p.T458I|FOXP4_ENST00000307972.4_Missense_Mutation_p.T471I|FOXP4_ENST00000373057.3_Missense_Mutation_p.T469I	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	471					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCCCCCTTCACCTACGCCTCC	0.647000													42	120					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17415923	17415923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17415923C>T	ENST00000302539.4	-	37	4563	c.4438G>A	c.(4438-4440)Gag>Aag	p.E1480K	ABCC8_ENST00000389817.3_Missense_Mutation_p.E1479K	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1479	ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTGAAATTCTCCCCGCCTTCT	0.562000													26	70					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990672	990672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:990672C>T	ENST00000190165.2	+	2	1124	c.1086C>T	c.(1084-1086)ttC>ttT	p.F362F		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	362					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		AGCCCCCTTTCCCCCAGCCAC	0.587000													11	58					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135745671	135745671	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:135745671C>A	ENST00000375845.3	-	7	801	c.771G>T	c.(769-771)gaG>gaT	p.E257D	MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000392915.1_Missense_Mutation_p.E274D|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000358371.4_Missense_Mutation_p.E144D	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		ATGGGCTGAGCTCATCAGATT	0.453000													37	90					4.92203e-23	4.9538e-23	1	1	0
SDPR	8436	broad.mit.edu	37	2	192701434	192701434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:192701434C>T	ENST00000304141.4	-	2	822	c.493G>A	c.(493-495)Gag>Aag	p.E165K		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	165						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCAGGGATCTCATTTTCCTCC	0.468000													16	19					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21991299	21991299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21991299C>T	ENST00000594012.1	-	7	2036	c.1522G>A	c.(1522-1524)Gaa>Aaa	p.E508K	ZNF43_ENST00000354959.4_Missense_Mutation_p.E514K|ZNF43_ENST00000598381.1_Missense_Mutation_p.E508K|ZNF43_ENST00000595461.1_Missense_Mutation_p.E508K	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TTGCCACATTCTTCACATTTG	0.373000													23	107					0	0	1	0	0
DAPK2	23604	broad.mit.edu	37	15	64275924	64275924	+	Missense_Mutation	SNP	C	C	T	rs145891572	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:64275924C>T	ENST00000261891.3	-	2	127	c.122G>A	c.(121-123)cGg>cAg	p.R41Q	DAPK2_ENST00000457488.1_Missense_Mutation_p.R41Q|DAPK2_ENST00000558482.1_5'UTR|DAPK2_ENST00000558069.1_Missense_Mutation_p.R41Q			Q9UIK4	DAPK2_HUMAN	death-associated protein kinase 2	41	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	11				LUAD - Lung adenocarcinoma(2;0.215)		GCTCTTCTCCCGGCACTTCTT	0.597000													8	59					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	123989367	123989367	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123989367C>T	ENST00000456829.2	+	6	848	c.597C>T	c.(595-597)tgC>tgT	p.C199C	VWA5A_ENST00000392744.4_Silent_p.C215C|VWA5A_ENST00000449321.1_Silent_p.C199C|VWA5A_ENST00000361352.5_Silent_p.C199C|VWA5A_ENST00000360334.4_Silent_p.C199C|VWA5A_ENST00000392748.1_Silent_p.C199C	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	199										autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						AATCCAACTGCCCCTTGAGTC	0.498000													12	53					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26128028	26128028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:26128028G>A	ENST00000381655.2	+	12	1297	c.1155G>A	c.(1153-1155)gtG>gtA	p.V385V	ATP8A2_ENST00000255283.8_Silent_p.V345V	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	345					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TTGAGGTTGTGAAGTATACTC	0.383000													42	90					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30510707	30510707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30510707G>A	ENST00000356798.6	+	17	2222	c.2042G>A	c.(2041-2043)cGg>cAg	p.R681Q	ITGAL_ENST00000358164.5_Missense_Mutation_p.R598Q|ITGAL_ENST00000433423.2_Missense_Mutation_p.R77Q|RP11-297C4.1_ENST00000563751.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	681					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity	p.R681Q(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GATGGCCACCGGACCAGAAGA	0.542000													13	164					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559839	44559839	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44559839C>T	ENST00000332567.4	-	1	2149	c.1797G>A	c.(1795-1797)caG>caA	p.Q599Q	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	599	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTTTGTTTTCCTGTGGCTTTT	0.493000													45	106					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212638	26212638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:26212638C>T	ENST00000379034.1	+	2	824	c.675C>T	c.(673-675)gtC>gtT	p.V225V		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	225	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						TGAAGTGTGTCCGCAGAGAGT	0.478000													33	22					0	0	1	0	0
RIC3	79608	broad.mit.edu	37	11	8132554	8132554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8132554C>T	ENST00000396677.2	-	3	314	c.315G>A	c.(313-315)atG>atA	p.M105I	RIC3_ENST00000335425.7_Missense_Mutation_p.M85I|RIC3_ENST00000539720.1_Missense_Mutation_p.M218I|RIC3_ENST00000343202.4_Missense_Mutation_p.M266I|RIC3_ENST00000530060.1_5'UTR|RIC3_ENST00000309737.6_Missense_Mutation_p.M267I|RIC3_ENST00000425599.2_Missense_Mutation_p.M186I			Q7Z5B4	RIC3_HUMAN	RIC3 acetylcholine receptor chaperone	267						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)	17				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		CCTCTTCTATCATTCCCATTC	0.448000													33	125					0	0	1	0	0
SV2C	22987	broad.mit.edu	37	5	75581606	75581606	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75581606G>A	ENST00000502798.2	+	6	1490	c.1047_splice	c.e6-1	p.V350_splice	RP11-466P24.6_ENST00000502589.1_RNA|SV2C_ENST00000322285.7_Splice_Site_p.V350_splice	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	350					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CATTTCTTAGGTTGGAAAACA	0.458000													23	56					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325003	150325003	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150325003C>T	ENST00000328902.5	-	3	899	c.683G>A	c.(682-684)gGa>gAa	p.G228E	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	228							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTAATAATCTCCTTCGTTTTC	0.512000													71	175					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776016	5776016	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5776016C>T	ENST00000317254.3	+	1	94	c.46C>T	c.(46-48)Ctg>Ttg	p.L16L	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TTCATTTATTCTGAATGGAGT	0.413000													27	59					0	0	1	0	0
KIAA0753	9851	broad.mit.edu	37	17	6498355	6498355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6498355G>A	ENST00000361413.3	-	16	2735	c.2377C>T	c.(2377-2379)Cgt>Tgt	p.R793C	KIAA0753_ENST00000575027.1_5'UTR|KIAA0753_ENST00000589033.1_Missense_Mutation_p.R249C|KIAA0753_ENST00000542606.1_Missense_Mutation_p.R494C|KIAA0753_ENST00000572370.1_Missense_Mutation_p.R494C	NM_014804.2	NP_055619.2	Q2KHM9	K0753_HUMAN	KIAA0753	793						centrosome				endometrium(4)|large_intestine(11)|lung(5)|prostate(4)	24				COAD - Colon adenocarcinoma(228;0.157)		TATCTTTGACGAACAGACTCC	0.308000													31	28					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53857356	53857356	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53857356C>T	ENST00000315251.5	-	3	1117	c.680G>A	c.(679-681)tGg>tAg	p.W227*		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase	227					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	CATGTCCATCCAGCCGAAGCC	0.607000													7	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594547	179594547	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179594547C>T	ENST00000589042.1	-	63	18657	c.18433G>A	c.(18433-18435)Gaa>Aaa	p.E6145K	TTN_ENST00000342992.6_Missense_Mutation_p.E4901K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E5828K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5828	Ig-like 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTTATTTCATTCCCGTCT	0.428000													35	53					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108776277	108776277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108776277C>T	ENST00000232603.5	-	13	1170	c.1088G>A	c.(1087-1089)cGa>cAa	p.R363Q	MORC1_ENST00000483760.1_Missense_Mutation_p.R363Q	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	363					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding	p.R363Q(1)		breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AGCTTGGCTTCGGTTTTCTAC	0.338000													22	102					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433147	140433147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140433147C>T	ENST00000306549.3	+	1	2169	c.2092C>T	c.(2092-2094)Ctt>Ttt	p.L698F		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		698					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTGGTCATCCTTTCCTTTCT	0.373000													51	174					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90427414	90427414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90427414C>T	ENST00000394375.3	+	4	337	c.224C>T	c.(223-225)cCt>cTt	p.P75L	LIPF_ENST00000238983.4_Missense_Mutation_p.P65L|LIPF_ENST00000355843.2_Missense_Mutation_p.P65L	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	65					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		AATAGAATTCCTTATGGGAAG	0.353000													26	133					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30672584	30672584	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30672584G>A	ENST00000376406.3	-	10	5023	c.4376C>T	c.(4375-4377)aCc>aTc	p.T1459I	MDC1_ENST00000376405.2_Missense_Mutation_p.T1195I|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1459	Interaction with the PRKDC complex.|Pro-rich.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						GTCTGTGGAGGTGGAAGGCTG	0.567000								Other conserved DNA damage response genes					129	188					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156277015	156277015	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156277015C>T	ENST00000311277.4	-	9	1406	c.1143G>A	c.(1141-1143)ttG>ttA	p.L381L	AC097467.2_ENST00000417474.1_RNA|MAP9_ENST00000515654.1_Silent_p.L357L|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000601977.1_RNA|AC097467.2_ENST00000593387.1_RNA	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	381					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TAGATTTCTTCAAAAACTCAG	0.343000													14	30					0	0	1	0	0
CMPK2	129607	broad.mit.edu	37	2	6991667	6991667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:6991667C>T	ENST00000256722.5	-	4	1139	c.1140G>A	c.(1138-1140)gaG>gaA	p.E380E	CMPK2_ENST00000458098.1_Intron|CMPK2_ENST00000404168.1_Silent_p.E380E|CMPK2_ENST00000478738.1_5'UTR	NM_207315.3	NP_997198.2	Q5EBM0	CMPK2_HUMAN	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	380					dTDP biosynthetic process	mitochondrion	ATP binding|cytidylate kinase activity|thymidylate kinase activity|UMP kinase activity			large_intestine(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GCAACCTCTCCTCAGGACTCA	0.587000													23	78					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100508335	100508335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:100508335C>T	ENST00000471714.1	-	55	4132	c.4023G>A	c.(4021-4023)gtG>gtA	p.V1341V	ABI3BP_ENST00000383691.4_Silent_p.V618V|ABI3BP_ENST00000284322.5_Silent_p.V664V			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	664						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TTCTGGGCCTCACAGTAGTAT	0.423000													4	6					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123845774	123845774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123845774G>A	ENST00000369005.1	+	4	4099	c.3759G>A	c.(3757-3759)gtG>gtA	p.V1253V	TACC2_ENST00000334433.3_Silent_p.V1253V|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Silent_p.V1253V|TACC2_ENST00000515273.1_Silent_p.V1253V|TACC2_ENST00000453444.2_Silent_p.V1253V	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1253						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACAGTGGAGTGAAAGCTGTTT	0.592000													17	141					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52420785	52420785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52420785C>T	ENST00000420323.2	+	56	9180	c.8919C>T	c.(8917-8919)acC>acT	p.T2973T		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2973	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGCCAGGCACCAAGGTGGATG	0.572000													4	6					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67132350	67132350	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67132350C>T	ENST00000284425.2	-	4	517	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	ABCA6_ENST00000590645.1_Missense_Mutation_p.E115K	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	115					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AGAAGTATTTCGTCCATGTGT	0.323000													4	11					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2298005	2298005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2298005C>T	ENST00000381458.5	+	7	920	c.857C>T	c.(856-858)tCt>tTt	p.S286F	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	286					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity	p.S286F(1)		breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	GCGCTGCGGTCTTTGGGGATT	0.582000													46	74					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20376776	20376776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20376776G>A	ENST00000302451.4	-	9	1451	c.1203C>T	c.(1201-1203)gtC>gtT	p.V401V		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	401	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						CTTTGTCAAAGACGACTACGT	0.438000													16	140					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047864	9047864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9047864G>A	ENST00000397910.4	-	5	33970	c.33767C>T	c.(33766-33768)tCc>tTc	p.S11256F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11258	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCACCAGTGGAGACAGTCAA	0.468000													3	22					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216680433	216680433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216680433C>T	ENST00000391890.3	-	9	1694	c.1177G>A	c.(1177-1179)Gaa>Aaa	p.E393K	ESRRG_ENST00000493748.1_Missense_Mutation_p.E386K|ESRRG_ENST00000366940.2_Missense_Mutation_p.E386K|ESRRG_ENST00000487276.1_Missense_Mutation_p.E386K|ESRRG_ENST00000361525.3_Missense_Mutation_p.E386K|ESRRG_ENST00000408911.3_Missense_Mutation_p.E409K|ESRRG_ENST00000366937.1_Missense_Mutation_p.E421K|ESRRG_ENST00000359162.2_Missense_Mutation_p.E386K|ESRRG_ENST00000360012.3_Missense_Mutation_p.E386K|ESRRG_ENST00000493603.1_Missense_Mutation_p.E386K|ESRRG_ENST00000361395.2_Missense_Mutation_p.E386K|ESRRG_ENST00000463665.1_Missense_Mutation_p.E347K|ESRRG_ENST00000366938.2_Missense_Mutation_p.E386K	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	409					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CGAGGGTCTTCCATGTGCTGG	0.507000													46	85					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145435641	145435641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145435641G>A	ENST00000511217.1	+	7	1472	c.1420G>A	c.(1420-1422)Ggt>Agt	p.G474S	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Missense_Mutation_p.G474S			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	474							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATTTCAGAAGGTGATCCACG	0.557000													66	182					0	0	1	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138768660	138768660	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138768660A>T	ENST00000242351.5	-	3	879	c.563T>A	c.(562-564)cTc>cAc	p.L188H	ZC3HAV1_ENST00000471652.1_Missense_Mutation_p.L188H|ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.L188H	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	188					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						ATGGGACCGGAGGCAGTTGGG	0.572000													16	50					0	0	1	0	0
MAGEH1	28986	broad.mit.edu	37	X	55479463	55479463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:55479463C>T	ENST00000342972.1	+	1	926	c.656C>T	c.(655-657)cCt>cTt	p.P219L		NM_014061.3	NP_054780.2	Q9H213	MAGH1_HUMAN	melanoma antigen family H, 1	219					apoptosis					central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|skin(2)	15						TATTCCGCCCCTTAAGTAGAT	0.493000													24	17					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3321352	3321352	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3321352G>A	ENST00000378398.3	+	8	1019	c.937G>A	c.(937-939)Gac>Aac	p.D313N	PRDM16_ENST00000378391.2_Missense_Mutation_p.D312N|PRDM16_ENST00000270722.5_Missense_Mutation_p.D312N|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Missense_Mutation_p.D312N|PRDM16_ENST00000441472.2_Missense_Mutation_p.D312N|PRDM16_ENST00000514189.1_Missense_Mutation_p.D313N|PRDM16_ENST00000511072.1_Missense_Mutation_p.D313N			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	312					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GTACAAATGCGACCAGTGTCC	0.607000			T	EVI1	"""MDS, AML"""								28	48					0	0	1	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32918430	32918430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32918430G>A	ENST00000374843.4	-	2	324	c.239C>T	c.(238-240)cCt>cTt	p.P80L	HLA-DMA_ENST00000395305.3_Intron|HLA-DMA_ENST00000464392.1_Intron|HLA-DMA_ENST00000395303.3_Missense_Mutation_p.P80L|XXbac-BPG181M17.5_ENST00000429234.1_Intron	NM_006120.3	NP_006111.2	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM alpha	80						integral to membrane|MHC class II protein complex				kidney(1)|large_intestine(2)|lung(8)	11						GGGCAGGCGAGGCACCCGAGT	0.537000													25	110					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149323835	149323835	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149323835G>T	ENST00000255266.5	-	1	521	c.402C>A	c.(400-402)ttC>ttA	p.F134L		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	134	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGTCCAAAGGGAAGACGATCT	0.567000													37	109					6.53348e-20	6.57384e-20	1	1	0
GRAMD4	23151	broad.mit.edu	37	22	47022730	47022730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:47022730G>A	ENST00000406902.1	+	2	247	c.34G>A	c.(34-36)Ggt>Agt	p.G12S	GRAMD4_ENST00000361034.3_Missense_Mutation_p.G12S			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	12					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CAGGTTCAGAGGTCACAAGAG	0.562000													14	65					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41010033	41010033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41010033G>A	ENST00000352632.3	+	12	1745	c.1659G>A	c.(1657-1659)gaG>gaA	p.E553E	SPTBN4_ENST00000344104.3_Silent_p.E553E|SPTBN4_ENST00000595535.1_Silent_p.E553E|SPTBN4_ENST00000598249.1_Silent_p.E553E|SPTBN4_ENST00000338932.3_Silent_p.E553E			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	553					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGATGGAGGAGATGCAGGTGC	0.622000													7	39					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81053203	81053203	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81053203C>T	ENST00000334512.5	+	12	1595	c.1023C>T	c.(1021-1023)tcC>tcT	p.S341S	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	341	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GGCCTGCCTCCATGGGGGGCA	0.667000													30	156					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	176580	176580	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:176580G>A	ENST00000538872.1	+	1	650	c.532G>A	c.(532-534)Ggc>Agc	p.G178S	IQSEC3_ENST00000326261.4_Missense_Mutation_p.G178S			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	178					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CCTCGGCAAGGGCGTCCTGAG	0.647000													5	31					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3721927	3721927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3721927G>A	ENST00000324932.7	-	24	4075	c.3655C>T	c.(3655-3657)Ctc>Ttc	p.L1219F	NUP98_ENST00000355260.3_Missense_Mutation_p.L1219F|NUP98_ENST00000359171.4_Missense_Mutation_p.L1219F	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1236					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		GGGACAATGAGAGGACACAGT	0.423000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								14	57					0	0	1	0	0
KIAA1430	57587	broad.mit.edu	37	4	186111405	186111405	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186111405C>T	ENST00000458385.2	-	2	1065	c.946G>A	c.(946-948)Gag>Aag	p.E316K	KIAA1430_ENST00000514798.1_Missense_Mutation_p.E316K|KIAA1430_ENST00000296775.6_Missense_Mutation_p.E316K	NM_020827.1	NP_065878.1	Q9P2B7	K1430_HUMAN	KIAA1430	316										endometrium(3)|kidney(2)|large_intestine(5)|upper_aerodigestive_tract(1)	11		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		ACATCAGGCTCATGTTTTTCT	0.348000													8	27					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321602	56321602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56321602G>A	ENST00000443188.1	-	5	1084	c.374C>T	c.(373-375)tCg>tTg	p.S125L	NLRP11_ENST00000589824.2_Missense_Mutation_p.S125L|NLRP11_ENST00000592953.1_Missense_Mutation_p.S26L|NLRP11_ENST00000589093.1_Missense_Mutation_p.S125L|NLRP11_ENST00000360133.3_Missense_Mutation_p.S125L	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	125							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CACATCTGACGAAACGTCACG	0.383000													23	46					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77425644	77425644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77425644G>A	ENST00000560626.2	-	6	4255	c.3780C>T	c.(3778-3780)ccC>ccT	p.P1260P	PEAK1_ENST00000312493.4_Silent_p.P1260P			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1260					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										GTCTGCAAGAGGGCCCACGCC	0.527000													49	135					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41839448	41839448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41839448G>A	ENST00000396930.3	-	5	1277	c.734C>T	c.(733-735)tCc>tTc	p.S245F	KAT6A_ENST00000485568.1_Missense_Mutation_p.S245F|KAT6A_ENST00000265713.2_Missense_Mutation_p.S245F|KAT6A_ENST00000406337.1_Missense_Mutation_p.S245F	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	245					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TAGTTCAGGGGAAAACTTTAA	0.413000													10	24					0	0	1	0	0
MOGAT2	80168	broad.mit.edu	37	11	75431059	75431059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75431059C>T	ENST00000198801.5	+	2	184	c.114C>T	c.(112-114)ttC>ttT	p.F38F	MOGAT2_ENST00000526712.1_5'UTR	NM_025098.2	NP_079374.2	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	38					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					CTGTGGGCTTCATAGCCCTCC	0.597000													80	177					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052501	15052501	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15052501C>T	ENST00000248072.3	+	1	201	c.201C>T	c.(199-201)tcC>tcT	p.S67S		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					CCAACCTGTCCTTTGCTGACA	0.483000													25	69					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21098223	21098223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21098223G>A	ENST00000261383.3	-	19	2823	c.2824C>T	c.(2824-2826)Ccc>Tcc	p.P942S	DNAH3_ENST00000415178.1_Missense_Mutation_p.P942S	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	942	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CTGAGGATGGGAATGTACTGC	0.512000													51	208					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51984482	51984482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51984482G>A	ENST00000220478.3	+	7	1220	c.817G>A	c.(817-819)Gaa>Aaa	p.E273K	SCG3_ENST00000542355.2_Missense_Mutation_p.E41K	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	273				EEL -> RDF (in Ref. 1; AAD44483).	platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		CAACTTTGAGGAACTCCAATA	0.383000													53	89					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21236075	21236075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21236075C>T	ENST00000233242.1	-	25	4300	c.4173G>A	c.(4171-4173)atG>atA	p.M1391I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1391					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGTCAGCCTTCATGTGGTAAC	0.532000													58	120					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5447853	5447853	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:5447853C>T	ENST00000296564.7	+	9	749	c.527C>T	c.(526-528)tCt>tTt	p.S176F	KIAA0947_ENST00000512608.1_3'UTR	NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	176										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						GACGAATTTTCTAAACAGAAA	0.303000													3	9					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96028737	96028737	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96028737G>A	ENST00000260766.3	+	17	4967	c.4333G>A	c.(4333-4335)Gat>Aat	p.D1445N	PLCE1_ENST00000371375.1_Missense_Mutation_p.D1137N|PLCE1_ENST00000371380.2_Missense_Mutation_p.D1445N|PLCE1_ENST00000371385.3_Missense_Mutation_p.D1137N	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1445	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GGACGGAGACGATGGGATGCC	0.453000													17	71					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154395381	154395381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154395381G>A	ENST00000435029.4	+	1	2122	c.1962G>A	c.(1960-1962)atG>atA	p.M654I		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	654					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGCGTCAAATGAAAGAGGATG	0.408000													39	147					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47842882	47842882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47842882G>A	ENST00000289672.2	-	53	7938	c.7888C>T	c.(7888-7890)Cct>Tct	p.P2630S	C7orf69_ENST00000418326.2_Intron|C7orf69_ENST00000258776.4_Intron	NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2630					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGAATGCCAGGAAGATAGACG	0.498000													32	46					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51255362	51255362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:51255362G>A	ENST00000404971.1	-	2	1389	c.50C>T	c.(49-51)tCg>tTg	p.S17L	NRXN1_ENST00000405581.1_Missense_Mutation_p.S17L|NRXN1_ENST00000402717.3_Missense_Mutation_p.S17L|NRXN1_ENST00000401669.2_Missense_Mutation_p.S17L|NRXN1_ENST00000406859.3_Missense_Mutation_p.S17L|NRXN1_ENST00000405472.3_Missense_Mutation_p.S17L|NRXN1_ENST00000406316.2_Missense_Mutation_p.S17L	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	17					adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAGCAGCAGCGAGAGGCACAG	0.716000													3	8					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176934326	176934326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176934326C>T	ENST00000367654.2	-	9	1608	c.1595G>A	c.(1594-1596)gGa>gAa	p.G532E	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.G524E|ASTN1_ENST00000367657.3_Missense_Mutation_p.G524E|ASTN1_ENST00000361833.2_Missense_Mutation_p.G524E			O14525	ASTN1_HUMAN	astrotactin 1	532					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GGGCTGCTCTCCCAAAACCAG	0.418000													33	95					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142564239	142564239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142564239C>T	ENST00000392957.2	+	10	2250	c.1463C>T	c.(1462-1464)cCc>cTc	p.P488L	EPHB6_ENST00000442129.1_Missense_Mutation_p.P488L|EPHB6_ENST00000411471.2_Missense_Mutation_p.P211L	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	488	Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					ACTCTAGTGCCCTCTGCTGTC	0.597000													17	43					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45472166	45472166	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45472166C>T	ENST00000291574.4	+	4	466	c.291C>T	c.(289-291)acC>acT	p.T97T	TRAPPC10_ENST00000380221.3_Silent_p.T97T	NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	97					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						TTTAGGATACCGAAGTGTATA	0.398000													8	117					0	0	1	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401213	11401213	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:11401213G>A	ENST00000002596.5	-	2	1591	c.417C>T	c.(415-417)tcC>tcT	p.S139S		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	139						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						GCAGCCGGATGGACGGGTTCA	0.587000													20	38					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142626122	142626122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142626122G>A	ENST00000265310.1	-	5	929	c.581C>T	c.(580-582)tCc>tTc	p.S194F	TRPV5_ENST00000442623.1_Missense_Mutation_p.S194F	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	194					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CTTACCCAGGGAGTCCTGGGC	0.612000													14	30					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50553013	50553013	+	Missense_Mutation	SNP	C	C	T	rs149927638	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50553013C>T	ENST00000262794.5	+	7	1171	c.1088C>T	c.(1087-1089)tCg>tTg	p.S363L	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000540615.1_Missense_Mutation_p.S343L|MOV10L1_ENST00000395858.3_Missense_Mutation_p.S363L|MOV10L1_ENST00000545383.1_Missense_Mutation_p.S363L	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	363					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TCTCAGATGTCGGAGAGCAGT	0.473000													16	65					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26868297	26868297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:26868297G>A	ENST00000381340.3	-	8	1206	c.790C>T	c.(790-792)Ctt>Ttt	p.L264F		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	264	MIR 3.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GTCGTACGAAGGAAAATGTGC	0.373000													28	133					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28710546	28710546	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28710546C>T	ENST00000257198.5	-	16	2877	c.2616G>A	c.(2614-2616)gaG>gaA	p.E872E	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257197.3_3'UTR	NM_024421.2	NP_077739.1	Q08554	DSC1_HUMAN	desmocollin 1	872					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ACTCCAGTCCCTCTTCTTCCT	0.423000													40	196					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2464818	2464818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2464818G>A	ENST00000278772.4	-	6	1276	c.789C>T	c.(787-789)ctC>ctT	p.L263L	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						TCTTCCCTAAGAGGGTCCTCG	0.433000													18	99					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108377998	108377998	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:108377998G>A	ENST00000263054.6	-	21	2836	c.2829C>T	c.(2827-2829)ttC>ttT	p.F943F	SORCS1_ENST00000344440.6_Silent_p.F943F|SORCS1_ENST00000478809.2_5'UTR|SORCS1_ENST00000369698.1_Silent_p.F478F	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	943						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAGTAAATCTGAAGGATATGC	0.458000													18	64					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49657924	49657924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49657924C>T	ENST00000252825.4	-	1	757	c.571G>A	c.(571-573)Gaa>Aaa	p.E191K	HRC_ENST00000595625.1_Missense_Mutation_p.E191K	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	191	4 X tandem repeats, acidic.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		tcttcTCCTTCATCATCTTCC	0.567000													29	54					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41710035	41710035	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41710035G>A	ENST00000400454.1	-	8	2253	c.1776C>T	c.(1774-1776)acC>acT	p.T592T		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	592	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TACCTTTCACGGTCACGTGGA	0.507000													46	101					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94674868	94674868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94674868C>T	ENST00000260526.6	-	4	561	c.379G>A	c.(379-381)Gat>Aat	p.D127N	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.D127N	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	127					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TGGAAGAGATCGTTTTTGTTT	0.323000													13	47					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65260293	65260293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65260293G>A	ENST00000389722.3	-	13	2141	c.2088C>T	c.(2086-2088)atC>atT	p.I696I	SPTB_ENST00000389720.3_Silent_p.I696I|SPTB_ENST00000389721.5_Silent_p.I696I|SPTB_ENST00000556626.1_Silent_p.I696I|SPTB_ENST00000542895.1_Silent_p.I696I	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	696					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTCCTGGAAGATCTGCTCCA	0.587000													19	25					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103300777	103300777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103300777C>T	ENST00000233969.2	+	5	1549	c.1407C>T	c.(1405-1407)ttC>ttT	p.F469F		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	469						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						TTGTCATATTCTTTACTGTCT	0.403000													62	172					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3655083	3655083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3655083C>T	ENST00000263087.4	-	15	1852	c.1754G>A	c.(1753-1755)gGg>gAg	p.G585E		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	585					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		ACTGAGATCCCCCATAGCCGC	0.557000													25	50					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118020103	118020103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:118020103G>A	ENST00000425217.1	-	6	1200	c.1146C>T	c.(1144-1146)atC>atT	p.I382I	KSR2_ENST00000302438.5_Silent_p.I108I|KSR2_ENST00000339824.5_Silent_p.I411I|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	411					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCTGTGCTTGATGGAGTTGC	0.592000													12	68					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158368677	158368677	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158368677G>A	ENST00000334438.1	-	1	579	c.580C>T	c.(580-582)Cat>Tat	p.H194Y		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TCTTTCACATGGGTGTCAGTG	0.438000													15	43					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54785280	54785280	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54785280C>T	ENST00000218436.6	-	8	1256	c.1227G>A	c.(1225-1227)gtG>gtA	p.V409V		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	409	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TGGAGAGGATCACACTGGGGG	0.627000													15	14					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139601552	139601552	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139601552G>A	ENST00000303045.6	-	65	5271	c.4825C>T	c.(4825-4827)Cag>Tag	p.Q1609*	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Nonsense_Mutation_p.Q1589*	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1609					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TAGGCACACTGGGAAGGGTCA	0.602000										HNSCC(7;0.00092)			12	38					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98058822	98058822	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:98058822G>A	ENST00000370192.3	-	10	1180	c.1080C>T	c.(1078-1080)ttC>ttT	p.F360F		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	360					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TGAAGACGATGAACACACGGC	0.458000													44	132					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49831696	49831696	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49831696G>A	ENST00000527477.1	+	0	1921																											AGAACTGTGAGCTTCGTTGAT	0.458000													55	103					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73491369	73491369	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73491369C>T	ENST00000314256.7	+	21	3127	c.2733C>T	c.(2731-2733)tcC>tcT	p.S911S	KIAA0195_ENST00000579208.1_Silent_p.S562S|KIAA0195_ENST00000375248.5_Silent_p.S921S	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	911					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCACAGTGTCCCGAGATGATG	0.592000													9	31					0	0	1	0	0
GIPR	2696	broad.mit.edu	37	19	46181175	46181175	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46181175C>T	ENST00000590918.1	+	11	1035	c.936C>T	c.(934-936)ctC>ctT	p.L312L	GIPR_ENST00000304207.8_Silent_p.L276L|GIPR_ENST00000593127.1_3'UTR|GIPR_ENST00000263281.3_Silent_p.L312L	NM_000164.2	NP_000155.1	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	312					generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				endometrium(1)|kidney(2)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	12		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		TTAATTTCCTCATTTTTATCC	0.567000													22	81					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124359953	124359953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124359953C>T	ENST00000409039.3	+	46	7785	c.7760C>T	c.(7759-7761)tCg>tTg	p.S2587L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2587	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.S1179L(1)|p.S2587L(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGATTTATTTCGCTATTCAGT	0.443000													14	50					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181689429	181689429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181689429C>T	ENST00000526775.1	+	14	2004	c.1839C>T	c.(1837-1839)ttC>ttT	p.F613F	CACNA1E_ENST00000367567.4_Silent_p.F220F|CACNA1E_ENST00000358338.5_Silent_p.F564F|CACNA1E_ENST00000367570.1_Silent_p.F613F|CACNA1E_ENST00000360108.3_Silent_p.F613F|CACNA1E_ENST00000367573.2_Silent_p.F613F|CACNA1E_ENST00000357570.5_Silent_p.F564F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	613					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TCTTCCTCTTCATCGTTGTCT	0.473000													12	28					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105767302	105767302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:105767302C>T	ENST00000374798.3	+	5	459	c.389C>T	c.(388-390)tCg>tTg	p.S130L	CYLC2_ENST00000487798.1_Missense_Mutation_p.S130L	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	130	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				ACAACAGATTCGGAATCAGAA	0.318000													17	38					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8928844	8928844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:8928844G>A	ENST00000256707.3	-	15	1901	c.1720C>T	c.(1720-1722)Ctc>Ttc	p.L574F	KIDINS220_ENST00000473731.1_Missense_Mutation_p.L574F|KIDINS220_ENST00000418530.1_Missense_Mutation_p.L532F|KIDINS220_ENST00000427284.1_Missense_Mutation_p.L574F|KIDINS220_ENST00000319688.5_Missense_Mutation_p.L575F	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	574	KAP NTPase.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AATTTAAGGAGGAGTTCCAAA	0.428000													35	98					0	0	1	0	0
KCNMB3	27094	broad.mit.edu	37	3	178968736	178968736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:178968736G>A	ENST00000392685.2	-	1	682	c.43C>T	c.(43-45)Ccc>Tcc	p.P15S	KCNMB3_ENST00000497599.1_Intron|KCNMB3_ENST00000485523.1_Intron|KCNMB3_ENST00000349697.2_Intron|KCNMB3_ENST00000314235.5_Intron	NM_171830.1	NP_741981.1	Q9NPA1	KCMB3_HUMAN	potassium large conductance calcium-activated channel, subfamily M beta member 3	0					detection of calcium ion|platelet activation|regulation of action potential in neuron	voltage-gated potassium channel complex	calcium-activated potassium channel activity|potassium channel regulator activity			NS(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_cancers(143;5.6e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;2.41e-27)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.03)			TGGGGAAAGGGAGAAGGAGAT	0.512000													11	82					0	0	1	0	0
ARL6IP5	10550	broad.mit.edu	37	3	69151000	69151000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:69151000C>T	ENST00000273258.3	+	2	291	c.187C>T	c.(187-189)Ccc>Tcc	p.P63S	ARL6IP5_ENST00000478935.1_Missense_Mutation_p.P63S	NM_006407.3	NP_006398.1	O75915	PRAF3_HUMAN	ADP-ribosylation-like factor 6 interacting protein 5	63					L-glutamate transport	endoplasmic reticulum membrane|integral to membrane				biliary_tract(1)|endometrium(1)|large_intestine(2)|ovary(1)|prostate(1)|urinary_tract(1)	7		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.78e-05)|Epithelial(33;0.000818)|LUSC - Lung squamous cell carcinoma(21;0.0118)|Lung(16;0.0189)|KIRC - Kidney renal clear cell carcinoma(39;0.203)|Kidney(39;0.238)		GTTTCTGAGTCCCTTCAACAT	0.453000													6	23					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121000554	121000554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121000554G>A	ENST00000392793.1	+	10	2846	c.2575G>A	c.(2575-2577)Gag>Aag	p.E859K	TECTA_ENST00000264037.2_Missense_Mutation_p.E859K			O75443	TECTA_HUMAN	tectorin alpha	859	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CGCCAGTGACGAGTTCTGTCT	0.537000													41	111					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161039388	161039388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161039388C>T	ENST00000368013.3	-	1	347	c.27G>A	c.(25-27)aaG>aaA	p.K9K	ARHGAP30_ENST00000368015.1_Intron|ARHGAP30_ENST00000368016.3_Silent_p.K9K	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	9					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CGCTGCCCTTCTTCTTTCCTT	0.622000													36	74					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42128555	42128555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42128555C>T	ENST00000401548.3	+	11	1319	c.1279C>T	c.(1279-1281)Cct>Tct	p.P427S	MEI1_ENST00000540833.1_Missense_Mutation_p.P167S|MEI1_ENST00000400107.1_5'UTR|MEI1_ENST00000300398.4_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	427							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						AGTTAGCAGCCCTGTGCTGGA	0.547000													27	37					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93902843	93902843	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:93902843G>A	ENST00000412050.4	-	6	1442	c.1354C>T	c.(1354-1356)Cct>Tct	p.P452S	CPEB3_ENST00000265997.4_Missense_Mutation_p.P466S	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	466	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				ACTACGAGAGGTCCAAACCTG	0.403000													22	57					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57399026	57399026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57399026C>T	ENST00000543257.1	-	11	1944	c.1378G>A	c.(1378-1380)Gga>Aga	p.G460R	C8B_ENST00000371237.4_Missense_Mutation_p.G512R|C8B_ENST00000535057.1_Missense_Mutation_p.G450R	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	512	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ACAGGGACTCCATTTCCTTGG	0.547000													33	64					0	0	1	0	0
KIAA0141	9812	broad.mit.edu	37	5	141309182	141309182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141309182C>T	ENST00000432126.2	+	5	582	c.448C>T	c.(448-450)Cca>Tca	p.P150S	KIAA0141_ENST00000194118.4_Missense_Mutation_p.P150S	NM_001142603.1|NM_014773.3	NP_001136075.1|NP_055588.3	Q14154	DELE_HUMAN	KIAA0141	150					apoptosis|regulation of caspase activity	mitochondrion	protein binding			endometrium(3)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(3)	16		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGATGGCCCAGCTCCCAG	0.602000													20	95					0	0	1	0	0
LMAN1	3998	broad.mit.edu	37	18	57013217	57013217	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:57013217G>A	ENST00000251047.5	-	8	1606	c.889C>T	c.(889-891)Caa>Taa	p.Q297*	LMAN1_ENST00000587940.1_5'UTR	NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1	297					blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	AATTCTTGTTGAAAGTGCTCA	0.418000													18	131					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54305645	54305645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54305645G>A	ENST00000545554.1	+	1	545	c.545G>A	c.(544-546)cGa>cAa	p.R182Q	UNC13C_ENST00000537900.1_Missense_Mutation_p.R182Q|UNC13C_ENST00000260323.11_Missense_Mutation_p.R182Q			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	182					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.R182Q(1)		breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGAGCTTTACGAAAACTGAGA	0.458000													39	98					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188592225	188592225	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:188592225C>T	ENST00000312675.4	+	11	2043	c.1797C>T	c.(1795-1797)gcC>gcT	p.A599A	LPP_ENST00000543006.1_Silent_p.A599A	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	599	LIM zinc-binding 3.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GCAACTCTGCCCGCATCAGGG	0.512000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								30	73					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29296383	29296383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29296383C>T	ENST00000331664.5	-	1	744	c.745G>A	c.(745-747)Gag>Aag	p.E249K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	249					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						GCCAGATCCTCCCTGACTTCC	0.552000													27	65					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080819	54080819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54080819C>T	ENST00000253144.9	+	7	2338	c.1005C>T	c.(1003-1005)gcC>gcT	p.A335A	ZNF331_ENST00000449416.1_Silent_p.A335A|ZNF331_ENST00000513999.1_Silent_p.A335A|ZNF331_ENST00000411977.2_Silent_p.A335A|ZNF331_ENST00000512387.1_Silent_p.A335A|ZNF331_ENST00000511154.1_Silent_p.A335A|ZNF331_ENST00000513265.1_3'UTR|ZNF331_ENST00000511593.2_Silent_p.A335A	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		GTGGGAAGGCCTTTCGCTGGG	0.512000			T	?	follicular thyroid adenoma								19	53					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1243835	1243835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1243835G>A	ENST00000324642.3	+	9	1420	c.1297G>A	c.(1297-1299)Ggg>Agg	p.G433R	SLC6A18_ENST00000296821.4_Intron	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	433					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GCTGGACGTGGGGGTCCTGCC	0.652000													8	52					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49292849	49292849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49292849G>A	ENST00000438782.1	+	7	795	c.559G>A	c.(559-561)Gac>Aac	p.D187N	CCDC36_ENST00000296449.5_Missense_Mutation_p.D187N|CCDC36_ENST00000452691.2_Missense_Mutation_p.D187N			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	187										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		GGCCCAGAATGACCTGGTGTT	0.453000													42	96					0	0	1	0	0
LGALS13	29124	broad.mit.edu	37	19	40097942	40097942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40097942G>A	ENST00000221797.4	+	4	428	c.383G>A	c.(382-384)aGa>aAa	p.R128K		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	128	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CAAGTGTCGAGAGATATCTCC	0.463000													10	97					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74825147	74825147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74825147G>A	ENST00000256362.4	+	2	1902	c.1661G>A	c.(1660-1662)gGc>gAc	p.G554D		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	554					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TGGCCCAGAGGCCTGTCCAAA	0.627000													37	100					0	0	1	0	0
PPM1M	132160	broad.mit.edu	37	3	52283280	52283280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52283280G>A	ENST00000296487.4	+	9	1098	c.694G>A	c.(694-696)Gag>Aag	p.E232K	PPM1M_ENST00000409502.3_Missense_Mutation_p.E181K|PPM1M_ENST00000323588.4_Missense_Mutation_p.E232K|PPM1M_ENST00000457351.2_Missense_Mutation_p.E393K			Q96MI6	PPM1M_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1M	232					protein dephosphorylation	nucleus	CTD phosphatase activity|manganese ion binding			prostate(1)|urinary_tract(1)	2				BRCA - Breast invasive adenocarcinoma(193;2.4e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)		ACTGTCCAACGAGCAGGTGGC	0.577000													5	22					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66075705	66075705	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:66075705C>T	ENST00000349533.6	+	13	2013	c.1828C>T	c.(1828-1830)Cag>Tag	p.Q610*	LEPR_ENST00000371058.1_Nonsense_Mutation_p.Q610*|LEPR_ENST00000344610.8_Nonsense_Mutation_p.Q610*|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371060.3_Nonsense_Mutation_p.Q610*|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000371059.3_Nonsense_Mutation_p.Q610*	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	610	Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CTATGCTGTTCAGGTGCGCTG	0.413000													72	174					0	0	1	0	0
MSI2	124540	broad.mit.edu	37	17	55704618	55704618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:55704618C>T	ENST00000284073.2	+	10	890	c.681C>T	c.(679-681)ggC>ggT	p.G227G	MSI2_ENST00000579180.1_Silent_p.G123G|MSI2_ENST00000579505.1_3'UTR|MSI2_ENST00000322684.3_Silent_p.G223G|MSI2_ENST00000442934.2_Silent_p.G166G|MSI2_ENST00000416426.2_Silent_p.G205G	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	227						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		CGACCTATGGCCGTGGCTACC	0.537000			T	HOXA9	CML								42	116					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51693482	51693482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51693482C>T	ENST00000267012.4	-	6	486	c.425G>A	c.(424-426)cGg>cAg	p.R142Q	BIN2_ENST00000544402.1_Missense_Mutation_p.R116Q|BIN2_ENST00000452142.2_Missense_Mutation_p.R110Q|BIN2_ENST00000604560.1_Missense_Mutation_p.R115Q	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	142	BAR.					cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						TTTCCGACCCCGCTTGGCAAT	0.498000													55	88					0	0	1	0	0
SEPN1	57190	broad.mit.edu	37	1	26138213	26138213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26138213C>T	ENST00000361547.2	+	9	1179	c.1124C>T	c.(1123-1125)cCc>cTc	p.P375L	SEPN1_ENST00000374315.1_Missense_Mutation_p.P341L|SEPN1_ENST00000354177.4_Missense_Mutation_p.P341L	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	375						endoplasmic reticulum membrane|extracellular region	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		CCCTCTGTGCCCTCCGTGATC	0.617000													4	7					0	0	1	0	0
RPL12P38	645688	broad.mit.edu	37	17	58511106	58511106	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58511106G>A	ENST00000588627.1	-	0	2251																											GCATTCCACAGCACCACTGTT	0.398000													13	43					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133306681	133306681	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:133306681G>A	ENST00000539605.1	-	10	8565	c.1881C>T	c.(1879-1881)gcC>gcT	p.A627A	ANKLE2_ENST00000542374.1_Intron|ANKLE2_ENST00000357997.5_Silent_p.A689A|ANKLE2_ENST00000542657.1_Silent_p.A44A|ANKLE2_ENST00000542282.1_Silent_p.A44A			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	689						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CTCCCGGCTCGGCGGCTTCTA	0.622000													12	97					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275789	130275789	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130275789G>A	ENST00000257359.6	-	9	3040	c.2334C>T	c.(2332-2334)agC>agT	p.S778S		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	778	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		AGGGCCGGAAGCTCTGCAGGC	0.582000													74	123					0	0	1	0	0
TBC1D24	57465	broad.mit.edu	37	16	2546536	2546536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2546536C>T	ENST00000567020.1	+	2	527	c.387C>T	c.(385-387)tcC>tcT	p.S129S	RP11-20I23.1_ENST00000564543.1_Silent_p.S129S|TBC1D24_ENST00000434757.2_Silent_p.S129S|TBC1D24_ENST00000293970.5_Silent_p.S129S	NM_020705.2	NP_065756.1	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	129	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity			endometrium(2)|kidney(4)|large_intestine(3)|lung(4)	13						CCGACATCTCCTTCTGCCCCG	0.667000													21	45					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33612897	33612897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:33612897C>T	ENST00000321505.4	+	11	3970	c.3790C>T	c.(3790-3792)Cct>Tct	p.P1264S	KIAA1549L_ENST00000265654.5_Intron|KIAA1549L_ENST00000389726.3_Missense_Mutation_p.P1270S					KIAA1549-like																		TAGAGATGCTCCTCAGGAAAG	0.557000													5	46					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69433848	69433848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69433848C>T	ENST00000317746.2	-	1	397	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	119					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.E119K(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						TCAGAATATTCCCAACACAAT	0.294000													37	140					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32031756	32031756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:32031756G>A	ENST00000360311.4	+	2	1734	c.1185G>A	c.(1183-1185)ggG>ggA	p.G395G		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G395G(2)		endometrium(3)|lung(4)|ovary(1)	8						ATGGTATAGGGAAACTTTATA	0.373000													18	78					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101567960	101567960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101567960C>T	ENST00000370449.4	+	13	1902	c.1789C>T	c.(1789-1791)Ccc>Tcc	p.P597S		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	597	ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GAGCATGCTTCCCATGATGAT	0.483000													58	161					0	0	1	0	0
GALNT11	63917	broad.mit.edu	37	7	151791331	151791331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151791331C>T	ENST00000434507.1	+	4	456	c.19C>T	c.(19-21)Cgg>Tgg	p.R7W	GALNT11_ENST00000482812.1_Intron|GALNT11_ENST00000430044.2_Missense_Mutation_p.R7W|GALNT11_ENST00000320311.2_Missense_Mutation_p.R7W|GALNT11_ENST00000452146.2_Intron|GALNT11_ENST00000422997.2_Missense_Mutation_p.R7W|GALNT11_ENST00000415421.1_Missense_Mutation_p.R7W			Q8NCW6	GLT11_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)	7						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|prostate(5)|skin(2)	27	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		TGTCACAGTTCGGTATTTCTG	0.368000													141	297					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46307838	46307838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46307838G>A	ENST00000221538.3	-	3	1467	c.1325C>T	c.(1324-1326)cCc>cTc	p.P442L	RSPH6A_ENST00000597055.1_Missense_Mutation_p.P442L|RSPH6A_ENST00000600188.1_Missense_Mutation_p.P178L	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	442						intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						AGTGACGTGGGGCAGCCGCGT	0.632000													18	66					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509295	71509295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71509295G>A	ENST00000396073.3	+	9	2433	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	718					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			TTATTACAGTGAATTTTACCC	0.388000													47	92					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55653197	55653197	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55653197A>T	ENST00000449290.2	+	2	385	c.293A>T	c.(292-294)gAg>gTg	p.E98V		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	98						intracellular	zinc ion binding										ATGCACAGAGAGACAAAGAAG	0.483000													10	33					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79030039	79030039	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79030039C>T	ENST00000446378.2	+	2	5482	c.5451C>T	c.(5449-5451)ctC>ctT	p.L1817L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1817						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTTCTGACCTCCTTGTAGAAC	0.378000													20	69					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121383391	121383391	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121383391C>T	ENST00000297848.3	+	48	5582	c.5311_splice	c.e48-1	p.A1771_splice	COL14A1_ENST00000247781.3_Splice_Site_p.A1676_splice	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1771	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCCTCTTTAGCTCCCCATCCA	0.517000													18	211					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835304	38835304	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38835304G>A	ENST00000449082.2	-	1	197	c.198C>T	c.(196-198)ttC>ttT	p.F66F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	66					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GCTCACCATAGAACTTGGGCA	0.542000													52	120					0	0	1	0	0
MRPL38	64978	broad.mit.edu	37	17	73900778	73900778	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73900778G>A	ENST00000309352.3	-	2	627	c.90C>T	c.(88-90)ccC>ccT	p.P30P	RP11-552F3.12_ENST00000587556.1_3'UTR|MRPL38_ENST00000409963.3_5'UTR|MRPL38_ENST00000585475.1_Intron	NM_032478.3	NP_115867.2	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38	30						actin cytoskeleton|mitochondrion|ribosome				ovary(1)|pancreas(1)|prostate(2)|skin(1)	5			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCCCAGCGGGGGTGTCCGGC	0.721000													5	11					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38876376	38876376	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38876376C>T	ENST00000274276.3	+	3	549	c.147C>T	c.(145-147)caC>caT	p.H49H	OSMR_ENST00000502536.1_Silent_p.H49H	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	49					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					AGAGTTTGCACTTACAATGGA	0.393000													18	83					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70681510	70681510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:70681510G>A	ENST00000377844.4	-	1	1081	c.322C>T	c.(322-324)Cct>Tct	p.P108S	ATXN8OS_ENST00000414504.2_RNA|KLHL1_ENST00000545028.1_5'UTR	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	108					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CCCTGCCCAGGAGCCCCTTGC	0.592000													27	45					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10798340	10798340	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10798340C>T	ENST00000449870.1	+	18	2707	c.2390C>T	c.(2389-2391)cCc>cTc	p.P797L	ILF3_ENST00000588657.1_Missense_Mutation_p.P797L|ILF3_ENST00000586544.1_3'UTR|ILF3_ENST00000318511.3_Missense_Mutation_p.P793L|ILF3_ENST00000590261.1_Missense_Mutation_p.P793L	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	793	Interaction with PRMT1.|Poly-Gly.			G -> R (in Ref. 4; CAC01124 and 6; AAK07425).	M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			TACAACTCTCCCGGGGGCGGG	0.602000													14	44					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540351	169540351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169540351G>A	ENST00000340806.6	+	1	642	c.642G>A	c.(640-642)caG>caA	p.Q214Q		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	214										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						CGGGGCTGCAGAAGTTCTATA	0.532000													44	93					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29752501	29752501	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29752501G>A	ENST00000357586.2	-	6	816	c.630C>T	c.(628-630)gcC>gcT	p.A210A	AP1B1_ENST00000405198.1_Silent_p.A210A|AP1B1_ENST00000402502.1_Silent_p.A210A|AP1B1_ENST00000432560.2_Silent_p.A210A|AP1B1_ENST00000356015.2_Silent_p.A210A|AP1B1_ENST00000317368.7_Silent_p.A210A|AP1B1_ENST00000415447.1_Silent_p.A210A	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	210					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						ACTCATTGAGGGCTGTCAGCA	0.602000													20	35					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	944731	944731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:944731C>T	ENST00000265846.5	-	5	686	c.467G>A	c.(466-468)cGa>cAa	p.R156Q	ADAP1_ENST00000463358.1_5'UTR|ADAP1_ENST00000449296.2_Missense_Mutation_p.R84Q|ADAP1_ENST00000539900.1_Missense_Mutation_p.R167Q	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	156	PH 1.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						AGCACCCTCTCGTTCTGTCAG	0.602000													32	54					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121290766	121290766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121290766G>A	ENST00000297848.3	+	28	3700	c.3430G>A	c.(3430-3432)Gga>Aga	p.G1144R	COL14A1_ENST00000247781.3_Missense_Mutation_p.G1049R|COL14A1_ENST00000309791.4_Missense_Mutation_p.G1144R	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1144	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TATAACTGATGGAAGATCACA	0.373000													20	46					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152520314	152520314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152520314C>T	ENST00000427231.2	-	45	5713	c.5511G>A	c.(5509-5511)ctG>ctA	p.L1837L	NEB_ENST00000409198.1_Silent_p.L1837L|NEB_ENST00000397345.3_Silent_p.L1837L|NEB_ENST00000604864.1_Silent_p.L1837L|NEB_ENST00000172853.10_Silent_p.L1837L|NEB_ENST00000603639.1_Silent_p.L1837L	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1837					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGTCATCTTCCAGGCTCCGGA	0.453000													22	70					0	0	1	0	0
IKZF5	64376	broad.mit.edu	37	10	124755623	124755623	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124755623C>T	ENST00000368886.5	-	4	523	c.203G>A	c.(202-204)gGa>gAa	p.G68E	PSTK_ENST00000497219.1_Intron	NM_001271840.1	NP_001258769.1	Q9H5V7	IKZF5_HUMAN	IKAROS family zinc finger 5 (Pegasus)	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|lung(3)|prostate(1)	6		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		TACTAACATTCCTGAGTTTTC	0.423000													31	76					0	0	1	0	0
C15orf54	400360	broad.mit.edu	37	15	39544722	39544722	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:39544722G>A	ENST00000318578.3	+	2	754	c.386G>A	c.(385-387)tGg>tAg	p.W129*	RP11-624L4.1_ENST00000558209.1_RNA|C15orf54_ENST00000561223.1_Nonsense_Mutation_p.W129*|RP11-624L4.1_ENST00000561058.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA	NM_207445.2	NP_997328.1	Q8N8G6	CO054_HUMAN	chromosome 15 open reading frame 54	129										NS(1)|haematopoietic_and_lymphoid_tissue(2)|lung(2)	5		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		TCTCCTGGGTGGAAGAACATG	0.468000													40	112					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110831353	110831353	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110831353G>A	ENST00000375820.4	-	31	2496	c.2375C>T	c.(2374-2376)tCc>tTc	p.S792F		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	792	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGACCCCACGGAGCCTGGCAA	0.607000													3	11					0	0	1	0	0
FAM109A	144717	broad.mit.edu	37	12	111801115	111801115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111801115G>A	ENST00000450786.2	-	2	220	c.59C>T	c.(58-60)tCg>tTg	p.S20L	FAM109A_ENST00000548163.1_Silent_p.F39F|FAM109A_ENST00000547838.2_Silent_p.F39F|FAM109A_ENST00000361483.3_Silent_p.F52F|FAM109A_ENST00000392658.5_Silent_p.F39F			Q8N4B1	SESQ1_HUMAN	family with sequence similarity 109, member A	0	PH.				endosome organization|receptor recycling|retrograde transport, endosome to Golgi	clathrin-coated vesicle|early endosome|recycling endosome|trans-Golgi network	protein homodimerization activity			breast(1)|endometrium(1)|lung(1)|ovary(1)	4						CGCGCAGCACGAACCAGCGCC	0.662000													7	34					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21992598	21992598	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21992598G>A	ENST00000594012.1	-	7	737	c.223C>T	c.(223-225)Cat>Tat	p.H75Y	ZNF43_ENST00000354959.4_Missense_Mutation_p.H81Y|ZNF43_ENST00000598381.1_Missense_Mutation_p.H75Y|ZNF43_ENST00000595461.1_Missense_Mutation_p.H75Y	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	81	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TGGGTAAAATGAGAACACATA	0.294000													13	90					0	0	1	0	0
CAPS2	84698	broad.mit.edu	37	12	75683475	75683475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:75683475C>T	ENST00000393284.3	-	14	1283	c.682G>A	c.(682-684)Gaa>Aaa	p.E228K	CAPS2_ENST00000409799.1_Missense_Mutation_p.E378K|CAPS2_ENST00000442339.2_Missense_Mutation_p.E50K|RP11-560G2.1_ENST00000549953.1_RNA|CAPS2_ENST00000409004.1_5'UTR|CAPS2_ENST00000409445.3_Missense_Mutation_p.E460K			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	460							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						CCATTTCCTTCCTTGTCCAAC	0.348000													10	123					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216498859	216498859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216498859C>T	ENST00000366943.2	-	6	1317	c.931G>A	c.(931-933)Gtc>Atc	p.V311I	USH2A_ENST00000307340.3_Missense_Mutation_p.V311I|USH2A_ENST00000366942.3_Missense_Mutation_p.V311I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	311	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAAGGGTGGACCCGCGGGTGG	0.527000										HNSCC(13;0.011)			19	81					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553026	140553026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140553026G>A	ENST00000231137.3	+	1	784	c.610G>A	c.(610-612)Gag>Aag	p.E204K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		204	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGATCGGGAAGAGATACCAGA	0.507000													9	88					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677770	37677770	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37677770G>A	ENST00000532828.2	-	5	920	c.669C>T	c.(667-669)ttC>ttT	p.F223F	ZNF585B_ENST00000527838.1_3'UTR|CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000312908.5_5'UTR|ZNF585B_ENST00000531805.1_Silent_p.F168F	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGTTATAAGGGAAACCTTTCC	0.388000													48	100					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50252883	50252883	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50252883G>A	ENST00000420502.1	+	0	518							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	AAGTCCTCAGGGGTCGTGGGT	0.582000													18	87					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77816807	77816807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77816807G>A	ENST00000334306.2	-	1	2195	c.2196C>T	c.(2194-2196)ttC>ttT	p.F732F		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	732																	GATAGACAGGGAAAATGGGCT	0.502000													105	229					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86200608	86200608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86200608G>A	ENST00000370571.2	-	59	5188	c.4822C>T	c.(4822-4824)Cat>Tat	p.H1608Y	COL24A1_ENST00000436319.1_Missense_Mutation_p.H1587Y	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1608	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTCAGTAAATGAAGGAAGTTC	0.428000													10	75					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30681077	30681077	+	Silent	SNP	G	G	A	rs144222920	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30681077G>A	ENST00000376406.3	-	5	1289	c.642C>T	c.(640-642)ttC>ttT	p.F214F	MDC1_ENST00000376405.2_Silent_p.F214F	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	214	Interaction with the MRN complex.|Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TGTTCAAATTGAAGGCAAAAG	0.527000								Other conserved DNA damage response genes					18	99					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220504278	220504278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220504278C>T	ENST00000358055.3	+	20	3610	c.3098C>T	c.(3097-3099)tCc>tTc	p.S1033F	SLC4A3_ENST00000273063.6_Missense_Mutation_p.S1060F|SLC4A3_ENST00000373760.2_Missense_Mutation_p.S1033F|SLC4A3_ENST00000373762.3_Missense_Mutation_p.S1060F|SLC4A3_ENST00000317151.3_Missense_Mutation_p.S1033F			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1033	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCATTGGCTCCCTGGGGGGG	0.652000													31	81					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54307109	54307109	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54307109C>T	ENST00000545554.1	+	1	2009	c.2009C>T	c.(2008-2010)tCa>tTa	p.S670L	UNC13C_ENST00000537900.1_Missense_Mutation_p.S670L|UNC13C_ENST00000260323.11_Missense_Mutation_p.S670L			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	670					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGCTTGGATTCATCCACCCAG	0.413000													30	69					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177142399	177142399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:177142399C>T	ENST00000296525.3	-	5	690	c.577G>A	c.(577-579)Gat>Aat	p.D193N	ASB5_ENST00000512254.1_Missense_Mutation_p.D140N	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	193					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TGGTCAACATCTATGCCCCAG	0.443000													11	108					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61778959	61778959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:61778959C>T	ENST00000325324.6	+	10	1029	c.860C>T	c.(859-861)tCa>tTa	p.S287L	IPO11_ENST00000409296.3_Missense_Mutation_p.S327L|KIF2A_ENST00000509663.2_Intron	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	287						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		CATCCTTTTTCATTTACTCCT	0.308000													33	48					0	0	1	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103599776	103599776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103599776G>A	ENST00000560869.1	+	10	2262	c.1623G>A	c.(1621-1623)aaG>aaA	p.K541K	TNFAIP2_ENST00000538222.1_Silent_p.K24K|TNFAIP2_ENST00000451723.2_Silent_p.K210K|TNFAIP2_ENST00000333007.1_Silent_p.K541K			Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	541					angiogenesis|cell differentiation	extracellular space				NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	11		Melanoma(154;0.155)	Epithelial(46;0.191)			TGGTCCTCAAGACGGCCGAGC	0.632000													24	70					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042709	74042709	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74042709C>T	ENST00000409561.1	+	3	1480	c.1359C>T	c.(1357-1359)ctC>ctT	p.L453L		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	453										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						ATACTTACCTCCCCCCGATCT	0.463000													17	22					0	0	1	0	0
GPR183	1880	broad.mit.edu	37	13	99947438	99947438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:99947438C>T	ENST00000376414.4	-	2	1045	c.962G>A	c.(961-963)aGg>aAg	p.R321K	UBAC2_ENST00000403766.3_Intron|UBAC2_ENST00000376440.2_Intron	NM_004951.4	NP_004942.1	P32249	GP183_HUMAN	G protein-coupled receptor 183	321					humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	23						TTTCAGCATCCTCATAACCTT	0.403000													15	94					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9337875	9337875	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:9337875G>A	ENST00000382496.5	-	4	839	c.174C>T	c.(172-174)ttC>ttT	p.F58F		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	58	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						TTAACTGCGAGAAATCCACAG	0.343000													26	93					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228673	142228673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142228673G>A	ENST00000519067.1	-	4	1216	c.913C>T	c.(913-915)Ctg>Ttg	p.L305L	SLC45A4_ENST00000433583.2_Silent_p.L298L|SLC45A4_ENST00000024061.3_Silent_p.L305L|SLC45A4_ENST00000517878.1_Silent_p.L356L			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	356					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			AGGCGGGGCAGCTTGGTCTTG	0.617000													15	55					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	938710	938710	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:938710C>T	ENST00000265846.5	-	10	1275	c.1056G>A	c.(1054-1056)caG>caA	p.Q352Q	ADAP1_ENST00000449296.2_Silent_p.Q280Q|ADAP1_ENST00000539900.1_Silent_p.Q363Q	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	352	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						CCACCGCCTTCTGGAAGGCCG	0.687000													18	54					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	938749	938749	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:938749C>T	ENST00000265846.5	-	10	1236	c.1017G>A	c.(1015-1017)gaG>gaA	p.E339E	ADAP1_ENST00000449296.2_Silent_p.E267E|ADAP1_ENST00000539900.1_Silent_p.E350E	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	339	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						CGGACTCCGTCTCGCAGGCAA	0.687000													17	59					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196659215	196659215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196659215C>T	ENST00000312428.6	-	57	10663	c.10563G>A	c.(10561-10563)acG>acA	p.T3521T	DNAH7_ENST00000409063.1_Silent_p.T4T	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3521	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATGGGTAACTCGTTAGCCACA	0.383000													35	86					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33879667	33879667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33879667C>T	ENST00000374408.3	-	1	537	c.441G>A	c.(439-441)gtG>gtA	p.V147V		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	147										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGAAGTGGACCACAGCCTGGG	0.612000													43	99					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51383417	51383417	+	Silent	SNP	G	G	A	rs139544303		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51383417G>A	ENST00000216392.7	-	9	1367	c.1035C>T	c.(1033-1035)ctC>ctT	p.L345L	PYGL_ENST00000532462.1_Silent_p.L345L|PYGL_ENST00000544180.2_Silent_p.L311L	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	345				AL -> RI (in Ref. 1; AAA52577).	glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	CAGGGATCGCGAGTGCAGGGT	0.483000													39	73					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156658	22156658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22156658C>T	ENST00000397126.4	-	4	1326	c.1178G>A	c.(1177-1179)gGa>gAa	p.G393E	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGGTTTCTCTCCAGTATGAAT	0.383000													7	77					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11236895	11236895	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:11236895G>A	ENST00000304623.8	-	10	1858	c.1669C>T	c.(1669-1671)Cag>Tag	p.Q557*	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Nonsense_Mutation_p.Q124*|CTNND2_ENST00000511377.1_Nonsense_Mutation_p.Q466*|CTNND2_ENST00000503622.1_Nonsense_Mutation_p.Q220*|CTNND2_ENST00000359640.2_Nonsense_Mutation_p.Q557*	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	557					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding	p.Q557K(1)|p.Q557E(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGCAACATCTGAATCACTTCC	0.483000													39	89					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52962009	52962009	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52962009C>T	ENST00000549343.1	-	8	1379	c.1341G>A	c.(1339-1341)ctG>ctA	p.L447L	KRT74_ENST00000305620.2_Silent_p.L433L			Q7RTS7	K2C74_HUMAN	keratin 74	433	Coil 2.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		TGTCCAGGGCCAGTTTCAGGC	0.647000													35	76					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50144128	50144128	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:50144128C>T	ENST00000376025.2	-	0	1377							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					CTCCTACAGTCATCATGCACC	0.458000													3	2					0	0	1	0	0
SPACA3	124912	broad.mit.edu	37	17	31324017	31324017	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:31324017C>T	ENST00000580599.1	+	4	702	c.293C>T	c.(292-294)tCa>tTa	p.S98L	SPACA3_ENST00000269053.3_Missense_Mutation_p.S167L|SPACA3_ENST00000394637.2_3'UTR|SPACA3_ENST00000394638.1_Missense_Mutation_p.S64L			Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	167					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			ATGTACTGCTCAGGTAGCTGG	0.592000													28	44					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9046907	9046907	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9046907G>A	ENST00000397910.4	-	5	34927	c.34724C>T	c.(34723-34725)gCc>gTc	p.A11575V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11577	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGCCACGTGGCTGTAGTCTC	0.517000													8	22					0	0	1	0	0
NMNAT1	64802	broad.mit.edu	37	1	10042714	10042714	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10042714C>T	ENST00000377205.1	+	5	939	c.795C>T	c.(793-795)gtC>gtT	p.V265V		NM_022787.3	NP_073624.2	Q9HAN9	NMNA1_HUMAN	nicotinamide nucleotide adenylyltransferase 1	265					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding			large_intestine(2)|lung(2)|stomach(1)	5		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		ATGCTGGGGTCATCCTGGCCC	0.453000													23	37					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027662	37027662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37027662G>A	ENST00000358047.3	+	1	1231	c.1179G>A	c.(1177-1179)gaG>gaA	p.E393E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	393										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCCGCCCAGAGACCCCCAAGA	0.607000													41	34					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167798579	167798579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167798579G>A	ENST00000367848.1	-	26	3897	c.3400C>T	c.(3400-3402)Cac>Tac	p.H1134Y	ADCY10_ENST00000545172.1_Missense_Mutation_p.H1073Y|ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Missense_Mutation_p.H1226Y			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1226					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TACTTGCAGTGAAAAAGATAA	0.433000													30	110					0	0	1	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147203	26147203	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:26147203C>T	ENST00000331351.5	+	2	1397	c.1005C>T	c.(1003-1005)atC>atT	p.I335I	HS3ST4_ENST00000475436.1_3'UTR	NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	335					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		GAATAGGGATCTATGCGCTGC	0.552000													80	166					0	0	1	0	0
LOC644669	644669	broad.mit.edu	37	18	15323268	15323268	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:15323268C>T	ENST00000455308.2	-	0	580					NR_027417.1																						TTAAACTTATCAACTGCAATT	0.299000													4	23					0	0	1	0	0
TRAPPC3	27095	broad.mit.edu	37	1	36605347	36605347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36605347G>A	ENST00000373166.3	-	3	304	c.214C>T	c.(214-216)Cgg>Tgg	p.R72W	TRAPPC3_ENST00000462715.1_5'UTR|TRAPPC3_ENST00000373163.1_Missense_Mutation_p.R26W|TRAPPC3_ENST00000373162.1_Missense_Mutation_p.R26W|TRAPPC3_ENST00000373159.1_Missense_Mutation_p.R72W	NM_001270896.1|NM_014408.3	NP_001257825.1|NP_055223.1	O43617	TPPC3_HUMAN	trafficking protein particle complex 3	72						endoplasmic reticulum	guanylate cyclase activity|heme binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Myeloproliferative disorder(586;0.0393)				GCAGTTTCCCGAAAGTCATGG	0.488000													18	43					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42732372	42732372	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42732372C>T	ENST00000287777.4	+	5	1729	c.1629C>T	c.(1627-1629)ttC>ttT	p.F543F		NM_152393.2	NP_689606.2			kelch-like family member 40																		TCGAGGCCTTCCCACAGGAGC	0.622000													15	45					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99439351	99439351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99439351C>T	ENST00000397899.2	-	7	1716	c.1385G>A	c.(1384-1386)aGa>aAa	p.R462K		NM_207362.2	NP_997245.2			KIAA1211-like																		CTCCGCTTCTCTCTCGGGCTC	0.746000													11	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061005	9061005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9061005C>T	ENST00000397910.4	-	3	26644	c.26441G>A	c.(26440-26442)gGa>gAa	p.G8814E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8816	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGTGAGTTCCTGGCCAGGA	0.542000													37	89					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60562911	60562911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:60562911G>A	ENST00000373886.3	+	15	2094	c.2090G>A	c.(2089-2091)gGg>gAg	p.G697E	BICC1_ENST00000263103.1_Missense_Mutation_p.G323E	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	697					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						AAGGCTCCAGGGAGTGAGCGC	0.532000													11	63					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73677285	73677285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73677285G>A	ENST00000339764.1	+	5	1346	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K	RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000543947.1_5'UTR|DNAJB13_ENST00000537753.1_5'UTR	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	199					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					CTTTGAGAAGGAAGGGGACCA	0.562000													6	25					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65053926	65053926	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65053926C>T	ENST00000298705.1	+	10	822	c.726C>T	c.(724-726)ttC>ttT	p.F242F	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	242																	TTTATACTTTCTGTACATATG	0.388000													7	59					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25470566	25470566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:25470566G>A	ENST00000278886.6	-	12	1614	c.1541C>T	c.(1540-1542)tCg>tTg	p.S514L	NINL_ENST00000422516.1_Missense_Mutation_p.S514L	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	514					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						CAGCCTCTCCGAATCCGAAAG	0.577000													53	114					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95159188	95159188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95159188G>A	ENST00000371501.4	-	13	1304	c.1182C>T	c.(1180-1182)ctC>ctT	p.L394L	MYOF_ENST00000371502.4_Silent_p.L394L|MYOF_ENST00000358334.5_Silent_p.L394L|MYOF_ENST00000371489.1_Silent_p.L394L|MYOF_ENST00000359263.4_Silent_p.L394L			Q9NZM1	MYOF_HUMAN	myoferlin	394	C2 3.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AAGGATCCACGAGATTTTTCT	0.348000													19	36					0	0	1	0	0
RPS24	6229	broad.mit.edu	37	10	79795386	79795386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:79795386C>T	ENST00000440692.1	+	3	329	c.187C>T	c.(187-189)Cat>Tat	p.H63Y	RPS24_ENST00000476545.1_3'UTR|RPS24_ENST00000435275.1_Missense_Mutation_p.H63Y|RPS24_ENST00000360830.4_Missense_Mutation_p.H63Y|RPS24_ENST00000372360.3_Missense_Mutation_p.H63Y	NM_001142285.1	NP_001135757.1	P62847	RS24_HUMAN	ribosomal protein S24	63					endocrine pancreas development|erythrocyte homeostasis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	nucleotide binding|structural constituent of ribosome|translation initiation factor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(2)|skin(1)	5	all_cancers(46;0.0343)|all_epithelial(25;0.000959)|Breast(12;0.00113)|Prostate(51;0.0095)		Epithelial(14;0.00128)|OV - Ovarian serous cystadenocarcinoma(4;0.00248)|all cancers(16;0.00428)			ATTCAGAACTCATTTTGGTGG	0.433000													65	187					0	0	1	0	0
RIMKLA	284716	broad.mit.edu	37	1	42875687	42875687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42875687C>T	ENST00000431473.3	+	4	643	c.514C>T	c.(514-516)Cac>Tac	p.H172Y		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	172	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						AGATAAACATCACCTCTCTGA	0.498000													57	185					0	0	1	0	0
DNAJC16	23341	broad.mit.edu	37	1	15874796	15874796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15874796C>T	ENST00000375847.3	+	7	1060	c.896C>T	c.(895-897)tCa>tTa	p.S299L	DNAJC16_ENST00000375838.1_Missense_Mutation_p.S299L|DNAJC16_ENST00000375849.1_Missense_Mutation_p.S299L	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	299					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GATTATTTATCATTTGGATAT	0.383000													17	48					0	0	1	0	0
IGHV1-46	28465	broad.mit.edu	37	14	106967409	106967409	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106967409C>T	ENST00000390622.2	-	0	350																											AAAATCCCTTCCTCAGCCCTG	0.557000													23	69					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4234802	4234802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4234802G>A	ENST00000221847.5	+	4	571	c.518G>A	c.(517-519)gGa>gAa	p.G173E		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	173	Fibronectin type-III 2.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGCGTCAGGGAGCTGCGCGC	0.612000													52	134					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17629689	17629689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17629689G>A	ENST00000262077.2	-	18	2740	c.2741C>T	c.(2740-2742)cCt>cTt	p.P914L	NUP153_ENST00000537253.1_Missense_Mutation_p.P945L	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	914					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			AGTCTGAGAAGGCCCAGAAGA	0.413000													38	93					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118598527	118598527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:118598527C>T	ENST00000336338.5	-	19	2616	c.2551G>A	c.(2551-2553)Gaa>Aaa	p.E851K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	851						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCAACAAGTTCCAAATAATTC	0.318000													28	63					0	0	1	0	0
MARK4	57787	broad.mit.edu	37	19	45801462	45801462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45801462C>T	ENST00000300843.4	+	16	2236	c.1939C>T	c.(1939-1941)Ccc>Tcc	p.P647S	MARK4_ENST00000262891.4_Intron	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	311					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CGCCTCTCTGCCCCAGGGATC	0.617000													21	39					0	0	1	0	0
NMNAT3	349565	broad.mit.edu	37	3	139297788	139297788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:139297788C>T	ENST00000406164.1	-	4	671	c.108G>A	c.(106-108)caG>caA	p.Q36Q	NMNAT3_ENST00000512391.1_Silent_p.Q73Q|NMNAT3_ENST00000406824.1_5'UTR|NMNAT3_ENST00000511444.1_Silent_p.Q36Q|NMNAT3_ENST00000413939.2_Intron|NMNAT3_ENST00000339837.5_Silent_p.Q36Q|RP11-319G6.1_ENST00000381790.3_RNA|NMNAT3_ENST00000296202.7_Silent_p.Q73Q|RP11-319G6.1_ENST00000515247.1_RNA|NMNAT3_ENST00000507242.1_5'UTR			Q96T66	NMNA3_HUMAN	nicotinamide nucleotide adenylyltransferase 3	73					water-soluble vitamin metabolic process	cytosol|mitochondrion	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)	9						AGTCGGATGTCTGCAGGGCCA	0.572000													21	53					0	0	1	0	0
VSX2	338917	broad.mit.edu	37	14	74711968	74711968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74711968G>A	ENST00000261980.2	+	3	646	c.556G>A	c.(556-558)Gag>Aag	p.E186K		NM_182894.2	NP_878314.1	P58304	VSX2_HUMAN	visual system homeobox 2	186					multicellular organismal development|response to stimulus|visual perception	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7				BRCA - Breast invasive adenocarcinoma(234;0.00154)		CATGAAAACGGAGCTGCCGGA	0.577000													15	55					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74625024	74625024	+	Silent	SNP	C	C	T	rs149610315		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74625024C>T	ENST00000321288.5	+	18	2385	c.2385C>T	c.(2383-2385)ttC>ttT	p.F795F	CCDC33_ENST00000268082.4_Silent_p.F185F|CCDC33_ENST00000558821.1_Silent_p.F185F|CCDC33_ENST00000398814.3_Silent_p.F592F			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	795							protein binding	p.F592F(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CTCTAGGCTTCCCTATGCTCT	0.562000													44	148					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107360936	107360936	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107360936C>T	ENST00000374779.2	-	1	852	c.759G>A	c.(757-759)ggG>ggA	p.G253G		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						GGAAGATGGTCCCACAGAATG	0.428000													22	85					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38753876	38753876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38753876G>A	ENST00000449082.2	-	22	3864	c.3865C>T	c.(3865-3867)Ctc>Ttc	p.L1289F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1289					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAGAAGATGAGGCAGACGAGG	0.537000													32	122					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	54015097	54015097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54015097C>T	ENST00000396328.1	-	3	401	c.162G>A	c.(160-162)gcG>gcA	p.A54A	WDR72_ENST00000559418.1_Silent_p.A54A|WDR72_ENST00000360509.5_Silent_p.A54A|WDR72_ENST00000557913.1_Silent_p.A54A	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	54								p.A54A(1)		NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		GGAGTTCTTTCGCTGAAATCT	0.353000													16	136					0	0	1	0	0
NPY1R	4886	broad.mit.edu	37	4	164247039	164247039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164247039G>A	ENST00000296533.2	-	2	1199	c.668C>T	c.(667-669)cCa>cTa	p.P223L	NPY1R_ENST00000509586.1_5'UTR	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	223					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAAACAAAGTGGACCAAAATA	0.353000													7	34					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105421934	105421934	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105421934C>T	ENST00000333244.5	-	5	471	c.352G>A	c.(352-354)Gag>Aag	p.E118K		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	118	PDZ.					nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCCTCCACCTCTGTCTTCAGC	0.587000													24	53					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124519294	124519294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:124519294C>T	ENST00000408936.3	+	4	547	c.365C>T	c.(364-366)tCc>tTc	p.S122F	DAB2IP_ENST00000487716.1_3'UTR|DAB2IP_ENST00000309989.1_5'UTR|DAB2IP_ENST00000259371.2_Missense_Mutation_p.S94F			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	122	PH.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						CACCCCAGGTCCCATCTGATG	0.667000													19	55					0	0	1	0	0
CHRNA7	1139	broad.mit.edu	37	15	32404046	32404046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:32404046C>T	ENST00000306901.3	+	4	393	c.296C>T	c.(295-297)aCt>aTt	p.T99I	CHRNA7_ENST00000455693.2_Intron|CHRNA7_ENST00000454250.3_Missense_Mutation_p.T128I	NM_000746.5	NP_000737.1	P36544	ACHA7_HUMAN	cholinergic receptor, nicotinic, alpha 7 (neuronal)	99					activation of MAPK activity|calcium ion transport|cellular calcium ion homeostasis|memory|negative regulation of tumor necrosis factor production|positive regulation of angiogenesis|positive regulation of cell proliferation|response to hypoxia|response to nicotine	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|beta-amyloid binding|chloride channel regulator activity|nicotinic acetylcholine-activated cation-selective channel activity|protein homodimerization activity|toxin binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(2)	12		all_lung(180;6.35e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)	Nicotine(DB00184)|Varenicline(DB01273)	GGGGTGAAGACTGTTCGTTTC	0.403000													49	127					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71479591	71479591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71479591G>A	ENST00000296755.7	+	3	606	c.308G>A	c.(307-309)cGa>cAa	p.R103Q		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	103						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTTCATCACCGAAGTGACGTT	0.493000													31	92					0	0	1	0	0
METTL8	79828	broad.mit.edu	37	2	172195966	172195966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:172195966G>A	ENST00000375258.3	-	4	549	c.334C>T	c.(334-336)Cct>Tct	p.P112S				B3KW44	B3KW44_HUMAN	methyltransferase like 8	112							methyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	11						AGAATTTCAGGAAATTCCCTC	0.358000													47	101					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240417	3240417	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3240417C>T	ENST00000217939.6	-	5	3463	c.3309G>A	c.(3307-3309)atG>atA	p.M1103I		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1103						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACATACTGCTCATTATACCCA	0.483000													27	15					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156128253	156128253	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156128253C>T	ENST00000368285.3	+	5	705	c.438C>T	c.(436-438)gcC>gcT	p.A146A	SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000368282.1_Silent_p.A146A|SEMA4A_ENST00000368286.2_Intron|SEMA4A_ENST00000355014.2_Silent_p.A146A|SEMA4A_ENST00000368284.1_Intron	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	146	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					GCACCTTCGCCTTCAGCCCTG	0.522000													18	197					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40853713	40853713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:40853713C>T	ENST00000255224.3	-	2	1049	c.681G>A	c.(679-681)ggG>ggA	p.G227G	SYT4_ENST00000586678.1_Intron|SYT4_ENST00000590752.1_Silent_p.G209G	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	227	C2 1.|Phospholipid binding (Probable).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						TGTAGGGTATCCCATAGAATG	0.398000													33	105					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42683154	42683154	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42683154G>A	ENST00000358131.5	+	5	1102	c.894G>A	c.(892-894)gaG>gaA	p.E298E	TOX2_ENST00000372999.1_Silent_p.E247E|TOX2_ENST00000435864.2_Silent_p.E167E|TOX2_ENST00000423191.1_Silent_p.E247E|TOX2_ENST00000341197.3_Silent_p.E289E	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCCTGGGAGAGGAACAGAAGC	0.572000													12	31					0	0	1	0	0
DNAJB13	374407	broad.mit.edu	37	11	73679447	73679447	+	Missense_Mutation	SNP	C	C	T	rs146910386	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73679447C>T	ENST00000339764.1	+	6	1415	c.664C>T	c.(664-666)Cgc>Tgc	p.R222C	RP11-167N4.2_ENST00000537019.1_RNA|DNAJB13_ENST00000543947.1_Missense_Mutation_p.R47C|DNAJB13_ENST00000537753.1_Missense_Mutation_p.R47C	NM_153614.2	NP_705842.2	P59910	DJB13_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 13	222					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding			large_intestine(3)|lung(2)	5	Breast(11;7.42e-05)					GCTACACCCTCGCTTCCGCAG	0.562000													27	43					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150835336	150835336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150835336C>T	ENST00000397238.2	+	12	1602	c.1602C>T	c.(1600-1602)tcC>tcT	p.S534S	AGAP3_ENST00000463381.1_Intron	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	498	PH.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						GCTCCTGCTCCGTTTCCAGCG	0.697000													8	14					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5841610	5841610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5841610C>T	ENST00000317037.2	+	1	67	c.45C>T	c.(43-45)atC>atT	p.I15I	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTCTTTATCTTGAATGGCG	0.507000													13	73					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30876227	30876227	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:30876227G>A	ENST00000251071.5	-	11	2759	c.2009C>T	c.(2008-2010)tCc>tTc	p.S670F	CAPRIN2_ENST00000298892.5_Missense_Mutation_p.S670F|CAPRIN2_ENST00000308433.5_Missense_Mutation_p.S337F|CAPRIN2_ENST00000417045.1_Missense_Mutation_p.S670F|CAPRIN2_ENST00000395805.2_Missense_Mutation_p.S670F	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	670					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					ACTTTGACTGGACAGATTTTG	0.358000													17	61					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111080842	111080842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111080842G>A	ENST00000360467.5	+	7	695	c.389G>A	c.(388-390)gGa>gAa	p.G130E		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	130					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGGCCCAGGGGAAGGCCGGGC	0.622000													18	83					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982475	36982475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36982475G>A	ENST00000274963.8	+	7	1048	c.877G>A	c.(877-879)Gag>Aag	p.E293K		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	293					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						AGCCATCACTGAGATGGTAAG	0.607000													15	29					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198950188	198950188	+	Silent	SNP	C	C	T	rs151231252		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:198950188C>T	ENST00000428675.1	+	2	2345	c.1947C>T	c.(1945-1947)atC>atT	p.I649I	PLCL1_ENST00000437704.2_Silent_p.I551I	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	649	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.I551I(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CCATGAGGATCGATTCCAGTA	0.423000													21	54					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25299361	25299361	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25299361C>T	ENST00000549804.2	+	0	98				SNORD116-2_ENST00000384274.1_RNA|SNHG14_ENST00000547292.1_RNA																							GTGCTTGGATCGATGATGAGT	0.493000													61	148					0	0	1	0	0
CERS5	91012	broad.mit.edu	37	12	50561058	50561058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50561058G>A	ENST00000317551.6	-	1	147	c.23C>T	c.(22-24)cCc>cTc	p.P8L	CERS5_ENST00000422340.2_5'UTR|CERS5_ENST00000547852.1_5'UTR	NM_147190.2	NP_671723.1	Q8N5B7	CERS5_HUMAN	ceramide synthase 5	8					ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CAAGCTTAGGGGTCCCTGCGC	0.697000													14	28					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401379	77401379	+	Missense_Mutation	SNP	C	C	T	rs146432168		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77401379C>T	ENST00000282849.5	-	4	1155	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	ADAMTS18_ENST00000567121.1_Intron	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	246					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTGCAACCTTCGATGGTGATA	0.483000													28	64					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73491370	73491370	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73491370C>T	ENST00000314256.7	+	21	3128	c.2734C>T	c.(2734-2736)Cga>Tga	p.R912*	KIAA0195_ENST00000579208.1_Nonsense_Mutation_p.R563*|KIAA0195_ENST00000375248.5_Nonsense_Mutation_p.R922*	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	912					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACAGTGTCCCGAGATGATGC	0.587000													9	31					0	0	1	0	0
EHD2	30846	broad.mit.edu	37	19	48220020	48220020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48220020G>A	ENST00000263277.3	+	2	402	c.151G>A	c.(151-153)Gag>Aag	p.E51K	EHD2_ENST00000538399.1_Intron|CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_014601.3	NP_055416.2	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	51					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			endometrium(3)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	19		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		GCCGGCCCTGGAGGACGCAGA	0.662000													11	25					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12576177	12576177	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12576177C>T	ENST00000397732.3	-	4	730	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K	ZNF709_ENST00000428311.1_Missense_Mutation_p.E187K|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						TGAGTTCTTTCATGTATTTGA	0.403000													36	98					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142480013	142480013	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142480013G>A	ENST00000603901.1	+	0	145					NR_001296.3																						CCACTTCTGCGGTGGCTCCCT	0.562000													18	218					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132560846	132560846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132560846C>T	ENST00000265342.7	-	10	1557	c.1308G>A	c.(1306-1308)aaG>aaA	p.K436K	FSTL4_ENST00000507112.1_5'UTR	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	436						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACTTACGGGTCTTTCTAGCTG	0.527000													30	64					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43576027	43576027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43576027C>T	ENST00000406487.1	-	4	887	c.789G>A	c.(787-789)gcG>gcA	p.A263A		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	263	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region		p.A263A(1)		central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GGTTAGAGTTCGCGAAGCAAG	0.443000													116	256					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89939773	89939773	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89939773G>A	ENST00000405460.2	+	14	2803	c.2707G>A	c.(2707-2709)Gaa>Aaa	p.E903K		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	903					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GATGATAAATGAAAGCAAAGG	0.294000													6	20					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24789026	24789026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24789026G>A	ENST00000310677.4	-	22	2768	c.2655C>T	c.(2653-2655)ttC>ttT	p.F885F	ADCY4_ENST00000554068.2_Silent_p.F885F|ADCY4_ENST00000418030.2_Silent_p.F885F	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	885					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		ATTCAGAGTAGAACTCCTTGA	0.488000													21	53					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143020469	143020469	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143020469G>A	ENST00000343257.2	+	6	851	c.764G>A	c.(763-765)gGg>gAg	p.G255E	CLCN1_ENST00000495612.1_Intron	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	255					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GTGTTCTGCGGGGTATATGAG	0.602000													25	66					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209807842	209807842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209807842G>A	ENST00000391911.1	-	5	903	c.514C>T	c.(514-516)Cgg>Tgg	p.R172W	LAMB3_ENST00000356082.4_Missense_Mutation_p.R172W|LAMB3_ENST00000367030.3_Missense_Mutation_p.R172W	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	172	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GACTGGCACCGAACATCCTGC	0.602000													34	83					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1670063	1670063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1670063C>T	ENST00000252804.4	-	10	1264	c.1214G>A	c.(1213-1215)gGg>gAg	p.G405E	PXDN_ENST00000483018.1_5'UTR	NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	405	Ig-like C2-type 2.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCCGCTGTCCCCCTGTACGAC	0.587000													9	36					0	0	1	0	0
TMEM44	93109	broad.mit.edu	37	3	194343970	194343970	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:194343970G>A	ENST00000392432.2	-	5	800	c.595C>T	c.(595-597)Ccc>Tcc	p.P199S	TMEM44_ENST00000273580.7_Missense_Mutation_p.P199S|TMEM44_ENST00000330115.3_Missense_Mutation_p.P96S|TMEM44_ENST00000473092.1_Missense_Mutation_p.P199S|TMEM44_ENST00000381975.3_Missense_Mutation_p.P199S|TMEM44_ENST00000347147.4_Missense_Mutation_p.P199S	NM_001166305.1	NP_001159777.1	Q2T9K0	TMM44_HUMAN	transmembrane protein 44	199						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|urinary_tract(1)	8	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		GAGAGAGGGGGGATCCGAGAA	0.592000													7	11					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31743776	31743776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31743776G>A	ENST00000375686.3	-	3	715	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	VWA7_ENST00000375688.4_Missense_Mutation_p.R160C|VWA7_ENST00000447450.1_Missense_Mutation_p.R160C|VWA7_ENST00000467576.1_Intron	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	160						extracellular region											AGGCGCTGGCGAGCCAGGGTG	0.667000													61	116					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21031193	21031193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21031193C>T	ENST00000247986.2	-	5	1180	c.870G>A	c.(868-870)tcG>tcA	p.S290S	KIF17_ENST00000400463.3_Silent_p.S290S|KIF17_ENST00000375044.1_Silent_p.S190S			Q9P2E2	KIF17_HUMAN	kinesin family member 17	290					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GCGTCAGCTTCGAGTCACGGT	0.617000													26	67					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48606480	48606480	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48606480C>T	ENST00000323776.5	+	18	2946	c.2784C>T	c.(2782-2784)atC>atT	p.I928I	MYCBPAP_ENST00000436259.2_Silent_p.I891I	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	891					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CCCCTGACATCATCCTCTCTT	0.517000													21	47					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215901705	215901705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215901705C>T	ENST00000366943.2	-	61	12119	c.11733G>A	c.(11731-11733)gaG>gaA	p.E3911E	USH2A_ENST00000307340.3_Silent_p.E3911E			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3911	Fibronectin type-III 24.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.E3911D(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAACAGACTCCTCTTCAATGC	0.453000										HNSCC(13;0.011)			19	35					0	0	1	0	0
STPG1	90529	broad.mit.edu	37	1	24696301	24696301	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24696301C>T	ENST00000374409.1	-	7	854	c.600G>A	c.(598-600)gtG>gtA	p.V200V	STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000337248.4_Silent_p.V200V|STPG1_ENST00000440416.1_Silent_p.V153V|STPG1_ENST00000003583.8_Silent_p.V153V	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		GCGACTGCTTCACAAGGGATT	0.393000													13	118					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760621	19760621	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19760621T>G	ENST00000357324.6	-	18	2490	c.2464A>C	c.(2464-2466)Acc>Ccc	p.T822P	ATP13A1_ENST00000291503.5_Missense_Mutation_p.T704P	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	822					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						TGGGGGTCGGTGGCCTGCAGG	0.692000													7	33					0	0	1	0	0
TRIM24	8805	broad.mit.edu	37	7	138235915	138235915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138235915C>T	ENST00000343526.4	+	8	1466	c.1251C>T	c.(1249-1251)atC>atT	p.I417I	TRIM24_ENST00000497516.1_3'UTR|TRIM24_ENST00000415680.2_Silent_p.I417I			O15164	TIF1A_HUMAN	tripartite motif containing 24	417					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						CTCAAAATATCATCAACTTAG	0.418000													61	150					0	0	1	0	0
FAM105B	90268	broad.mit.edu	37	5	14693021	14693021	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14693021C>T	ENST00000284274.4	+	7	1001	c.923C>T	c.(922-924)tCc>tTc	p.S308F		NM_138348.4	NP_612357.4	Q96BN8	F105B_HUMAN	family with sequence similarity 105, member B	308										breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	14	Lung NSC(4;0.00696)					TACCGGCTCTCCAAGTACAAC	0.522000													35	90					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5247885	5247885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5247885C>T	ENST00000335295.3	-	2	412	c.237G>A	c.(235-237)ctG>ctA	p.L79L		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	79			L -> R (in Quin-hai).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	TGAGGTTGTCCAGGTGAGCCA	0.542000									Sickle Cell Trait				25	109					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130761	20130761	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20130761C>T	ENST00000334554.7	+	10	1749	c.1608C>T	c.(1606-1608)ccC>ccT	p.P536P	ZDHHC8_ENST00000405930.3_Silent_p.P536P|ZDHHC8_ENST00000320602.7_Silent_p.P444P	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	536						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					CCCGGGAGCCCTCGCCTGTGC	0.706000													15	26					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170278	90170278	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:90170278G>A	ENST00000333209.3	-	2	1502	c.984C>T	c.(982-984)gtC>gtT	p.V328V		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	328										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		ATCTGCTCTCGACACTCGCCA	0.527000													42	93					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63019376	63019376	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:63019376G>A	ENST00000561311.1	+	27	3576	c.3346G>A	c.(3346-3348)Gaa>Aaa	p.E1116K	TLN2_ENST00000306829.6_Missense_Mutation_p.E1116K			Q9Y4G6	TLN2_HUMAN	talin 2	1116	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TCAAGGCAACGAACACTACAC	0.562000													7	49					0	0	1	0	0
ANKRD2	26287	broad.mit.edu	37	10	99337563	99337563	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99337563C>T	ENST00000307518.5	+	2	442	c.175C>T	c.(175-177)Cga>Tga	p.R59*	ANKRD2_ENST00000298808.5_Nonsense_Mutation_p.R59*|ANKRD2_ENST00000455090.1_Nonsense_Mutation_p.R32*|ANKRD2_ENST00000370655.1_Nonsense_Mutation_p.R32*			Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 (stretch responsive muscle)	59					muscle contraction|muscle organ development		structural constituent of muscle	p.R59*(1)		breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		CCAGAAACTCCGAGGAGACGC	0.607000													2	2					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3643301	3643301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3643301G>A	ENST00000335312.3	-	13	1677	c.1589C>T	c.(1588-1590)tCc>tTc	p.S530F	PIP5K1C_ENST00000589578.1_Missense_Mutation_p.S530F|PIP5K1C_ENST00000539785.1_Missense_Mutation_p.S530F|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.S530F	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	530					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		GAGGGATGTGGATGACAGAGT	0.662000													42	101					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58285269	58285269	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:58285269C>T	ENST00000249750.4	-	6	1325	c.558G>A	c.(556-558)tgG>tgA	p.W186*	ALDH1A2_ENST00000347587.3_Nonsense_Mutation_p.W186*|ALDH1A2_ENST00000559517.1_Nonsense_Mutation_p.W90*|ALDH1A2_ENST00000558231.1_Nonsense_Mutation_p.W157*|ALDH1A2_ENST00000537372.1_Nonsense_Mutation_p.W165*	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	186					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GGGGGAAGTTCCACTGAAAGG	0.418000													15	56					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33650113	33650113	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33650113G>A	ENST00000399362.4	-	14	1747	c.1394C>T	c.(1393-1395)tCa>tTa	p.S465L	CLASP2_ENST00000480013.1_Missense_Mutation_p.S232L|CLASP2_ENST00000487200.1_Missense_Mutation_p.S238L|CLASP2_ENST00000359576.5_Missense_Mutation_p.S465L|CLASP2_ENST00000333778.6_Missense_Mutation_p.S242L|CLASP2_ENST00000313350.6_Missense_Mutation_p.S238L|CLASP2_ENST00000539981.1_Missense_Mutation_p.S217L|CLASP2_ENST00000461133.3_Missense_Mutation_p.S232L|CLASP2_ENST00000468888.2_Missense_Mutation_p.S466L|CLASP2_ENST00000307312.7_5'UTR	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	466										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						AAATTCAAATGAACGTCTGAA	0.343000													9	18					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434306	72434306	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:72434306T>C	ENST00000373517.3	-	1	378	c.23A>G	c.(22-24)aAg>aGg	p.K8R	NAP1L2_ENST00000536638.1_Intron	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	8					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TGACAGCTCCTTGCGGTTCTC	0.547000													25	32					0	0	1	0	0
LINC00842	643650	broad.mit.edu	37	10	47133709	47133709	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:47133709G>A	ENST00000422732.2	-	0	435					NR_033957.1																						GAACCACTTCGACCTCTTTGG	0.468000													18	143					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37605969	37605969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:37605969C>T	ENST00000505425.1	-	16	2787	c.2788G>A	c.(2788-2790)Gaa>Aaa	p.E930K	MDGA1_ENST00000434837.2_Intron|MDGA1_ENST00000297153.7_Intron			Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	930					brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						CCACCTCCTTCCCGTCTTGCA	0.582000													18	27					0	0	1	0	0
SYNDIG1	79953	broad.mit.edu	37	20	24523781	24523781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:24523781C>T	ENST00000376862.3	+	2	681	c.48C>T	c.(46-48)atC>atT	p.I16I		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	16					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						ACAGTAAAATCAGTGATGCTG	0.517000													31	66					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45914634	45914634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45914634C>T	ENST00000348697.2	+	2	299	c.152C>T	c.(151-153)tCg>tTg	p.S51L	FBLN1_ENST00000340923.5_Missense_Mutation_p.S51L|FBLN1_ENST00000402984.3_Missense_Mutation_p.S51L|FBLN1_ENST00000442170.2_Missense_Mutation_p.S51L|FBLN1_ENST00000327858.6_Missense_Mutation_p.S51L|FBLN1_ENST00000262722.7_Missense_Mutation_p.S51L			P23142	FBLN1_HUMAN	fibulin 1	51	Anaphylatoxin-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding	p.S51W(3)		biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		AAGGACTGCTCGCTGCCATAT	0.552000													5	10					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149460492	149460492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149460492C>T	ENST00000286301.3	-	3	436	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	CSF1R_ENST00000543093.1_Missense_Mutation_p.E49K	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	49	Ig-like C2-type 1.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CCATCCCATTCCACGCTGCCA	0.587000													13	24					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31672723	31672723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31672723C>T	ENST00000375483.3	+	4	703	c.703C>T	c.(703-705)Cct>Tct	p.P235S		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	235						cytoplasm|extracellular region	lipid binding										GCTGACCCTCCCTCGGGTGTC	0.667000													15	16					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69320593	69320593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:69320593C>T	ENST00000260364.5	+	4	460	c.159C>T	c.(157-159)tcC>tcT	p.S53S	NOX5_ENST00000455873.3_Silent_p.S64S|NOX5_ENST00000448182.3_Silent_p.S53S|NOX5_ENST00000530406.2_Silent_p.S71S|NOX5_ENST00000388866.3_Silent_p.S71S|RP11-809H16.2_ENST00000557966.1_RNA			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	71	EF-hand 1.|N-terminal regulatory region; interacts with the C-terminal catalytic region in a calcium-dependent manner.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						TATTTGACTCCGATAGAAGTG	0.552000													34	197					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142609852	142609852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142609852C>T	ENST00000265310.1	-	13	1932	c.1584G>A	c.(1582-1584)atG>atA	p.M528I		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	528					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					TGAACAGTGCCATGGGGTAGT	0.498000													37	83					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12270755	12270755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12270755C>T	ENST00000256194.4	+	22	3097	c.2809C>T	c.(2809-2811)Cat>Tat	p.H937Y	MICAL2_ENST00000527546.1_Missense_Mutation_p.H747Y|MICAL2_ENST00000342902.5_Intron|MICAL2_ENST00000537344.1_Missense_Mutation_p.H747Y|MICAL2_ENST00000379612.3_Missense_Mutation_p.H747Y	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	937						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		ttcagggttccattttcatcc	0.458000													25	49					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814477	242814477	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242814477G>A	ENST00000343216.3	+	2	798	c.770G>A	c.(769-771)gGg>gAg	p.G257E		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	257						integral to membrane											GCCATGCCTGGGGGCAAAGGC	0.667000													19	39					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144769802	144769802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:144769802C>T	ENST00000367545.3	+	16	1969	c.1969C>T	c.(1969-1971)Cgt>Tgt	p.R657C		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	657	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding	p.R657C(1)		NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GGAGACTGTTCGTGTAAGAGA	0.423000													18	113					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79025987	79025987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79025987G>A	ENST00000446378.2	+	2	1430	c.1399G>A	c.(1399-1401)Gaa>Aaa	p.E467K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	467						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGAAAGGGCAGAACCAGTCTC	0.512000													38	116					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33895342	33895342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33895342C>T	ENST00000389232.4	+	18	2011	c.1941C>T	c.(1939-1941)ttC>ttT	p.F647F	RYR3_ENST00000415757.3_Silent_p.F647F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	647	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAAACATCTTCCTGGGAGTCG	0.522000													22	109					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37482128	37482128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37482128G>A	ENST00000374660.1	+	33	2844	c.2745G>A	c.(2743-2745)atG>atA	p.M915I	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.M796I|ANKRD30A_ENST00000475522.1_3'UTR|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.M796I			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	967						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CCTGCAGAATGAAAGTTTCTA	0.269000													44	97					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28996398	28996398	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:28996398G>A	ENST00000322982.3	-	0	1536							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										AGCGGTCAGGGAAGCTGAGGG	0.687000													18	69					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76464930	76464930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76464930C>T	ENST00000389840.5	-	55	8629	c.8505G>A	c.(8503-8505)gtG>gtA	p.V2835V	DNAH17_ENST00000585328.1_Silent_p.V2844V|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GAACGTTCTTCACGGCAGCCT	0.542000													20	49					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192053172	192053172	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:192053172C>G	ENST00000454309.2	-	3	1217	c.392G>C	c.(391-393)gGt>gCt	p.G131A	FGF12_ENST00000264730.3_Missense_Mutation_p.G69A|FGF12_ENST00000445105.1_Missense_Mutation_p.G69A|FGF12_ENST00000430714.1_Missense_Mutation_p.G32A|FGF12_ENST00000450716.1_Missense_Mutation_p.G69A	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	131					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		ATAGCCTTCACCATTCATGGC	0.463000													22	98					0	0	1	0	0
LANCL3	347404	broad.mit.edu	37	X	37518741	37518741	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37518741C>T	ENST00000378621.3	+	3	1026	c.724C>T	c.(724-726)Ctt>Ttt	p.L242F	LANCL3_ENST00000378619.3_Missense_Mutation_p.L242F|TM4SF2_ENST00000465127.1_Intron	NM_198511.2	NP_940913.1	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3 (bacterial)	242							catalytic activity			lung(4)|pancreas(1)	5						GTCGTCTATTCTTCAGATGCT	0.433000													15	19					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25572670	25572670	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:25572670G>A	ENST00000269141.3	-	9	1716	c.1293C>T	c.(1291-1293)ttC>ttT	p.F431F	CDH2_ENST00000399380.3_Silent_p.F400F	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	431	Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TCTGGATGGCGAACCGTCCAG	0.527000													31	84					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43847746	43847746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43847746C>T	ENST00000389420.3	-	12	1723	c.1724G>A	c.(1723-1725)gGa>gAa	p.G575E	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.G575E	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	575	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACTTTCGATTCCGCCTCCACA	0.418000													6	15					0	0	1	0	0
FLAD1	80308	broad.mit.edu	37	1	154960590	154960590	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154960590C>T	ENST00000368433.1	+	2	725	c.382C>T	c.(382-384)Cag>Tag	p.Q128*	FLAD1_ENST00000292180.3_Nonsense_Mutation_p.Q128*|FLAD1_ENST00000368432.1_Nonsense_Mutation_p.Q31*|FLAD1_ENST00000368431.3_Nonsense_Mutation_p.Q29*|FLAD1_ENST00000487371.1_3'UTR|FLAD1_ENST00000405236.2_Nonsense_Mutation_p.Q29*|FLAD1_ENST00000295530.2_5'UTR|FLAD1_ENST00000315144.10_Nonsense_Mutation_p.Q31*			Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	128	Molybdenum cofactor biosynthesis protein- like.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGGACACACTCAGGACACCAA	0.562000													46	148					0	0	1	0	0
NUAK1	9891	broad.mit.edu	37	12	106460850	106460850	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:106460850G>A	ENST00000261402.2	-	7	3095	c.1716C>T	c.(1714-1716)atC>atT	p.I572I		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	572							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TGTCATCGCTGATGACACTGG	0.617000													18	28					0	0	1	0	0
KCNJ16	3773	broad.mit.edu	37	17	68129141	68129141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:68129141C>T	ENST00000585558.1	+	4	1406	c.1018C>T	c.(1018-1020)Ctc>Ttc	p.L340F	KCNJ16_ENST00000283936.1_Missense_Mutation_p.L305F|KCNJ16_ENST00000586462.1_Missense_Mutation_p.L344F|KCNJ16_ENST00000392671.1_Missense_Mutation_p.L305F|KCNJ16_ENST00000589377.1_Missense_Mutation_p.L305F|KCNJ16_ENST00000392670.1_Missense_Mutation_p.L305F			Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 16	305					synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	32	Breast(10;2.96e-09)					CCGAGAAATTCTCTGGGGCCA	0.403000													33	116					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071953	9071953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9071953G>A	ENST00000397910.4	-	3	15696	c.15493C>T	c.(15493-15495)Cct>Tct	p.P5165S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5167	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATGTGGAAGGAGCTGGATCT	0.488000													57	195					0	0	1	0	0
TMEM8B	51754	broad.mit.edu	37	9	35853227	35853227	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35853227C>T	ENST00000377988.2	+	12	2344	c.1056C>T	c.(1054-1056)ttC>ttT	p.F352F	TMEM8B_ENST00000377991.4_Silent_p.F352F	NM_001042590.2	NP_001036055.1	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B	352					cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	7						CCAGTCTCTTCGCCCTGGGGA	0.612000													28	105					0	0	1	0	0
PDIK1L	149420	broad.mit.edu	37	1	26440953	26440953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26440953C>T	ENST00000374271.4	+	3	441	c.154C>T	c.(154-156)Cgt>Tgt	p.R52C	PDIK1L_ENST00000374269.1_Missense_Mutation_p.R52C	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	52	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		ACTAGCCCTTCGTGAGTTCTG	0.458000													10	34					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128564722	128564722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:128564722C>T	ENST00000335251.5	+	2	296	c.193C>T	c.(193-195)Ctg>Ttg	p.L65L	INTU_ENST00000296461.5_Silent_p.L65L	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	65										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						AAATGGAGAGCTGTTTTATTT	0.388000													81	222					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331609	85331609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85331609G>A	ENST00000440886.1	-	1	233	c.195C>T	c.(193-195)ttC>ttT	p.F65F	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Silent_p.F65F			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	65					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						ACAGGTAGTAGAAGGGGAAAT	0.393000													26	129					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95132727	95132727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95132727G>A	ENST00000371501.4	-	24	2539	c.2417C>T	c.(2416-2418)tCt>tTt	p.S806F	MYOF_ENST00000371502.4_Missense_Mutation_p.S806F|MYOF_ENST00000358334.5_Missense_Mutation_p.S793F|MYOF_ENST00000359263.4_Missense_Mutation_p.S806F			Q9NZM1	MYOF_HUMAN	myoferlin	806					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GTATTTTCCAGATGCATTCTC	0.453000													10	134					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151927040	151927040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151927040G>A	ENST00000355193.2	-	18	3162	c.2944C>T	c.(2944-2946)Cag>Tag	p.Q982*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.Q982*					lysine (K)-specific methyltransferase 2C																		TGGTAACACTGACCACACTGA	0.343000													26	472					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3823288	3823288	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3823288C>T	ENST00000262961.4	-	8	1337	c.1327G>A	c.(1327-1329)Ggc>Agc	p.G443S		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	443						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		TCAGAGCAGCCCGCGGGAGCT	0.627000													45	128					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6753012	6753012	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:6753012C>T	ENST00000230859.6	+	12	1425	c.1296C>T	c.(1294-1296)acC>acT	p.T432T		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	432					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CTCCACCGACCCTAGGGGTTG	0.527000													31	73					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11150225	11150225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11150225C>T	ENST00000358026.2	+	30	4546	c.4262C>T	c.(4261-4263)tCa>tTa	p.S1421L	SMARCA4_ENST00000589677.1_Intron|SMARCA4_ENST00000429416.3_Intron|SMARCA4_ENST00000344626.4_Intron|SMARCA4_ENST00000590574.1_Intron|SMARCA4_ENST00000413806.3_Intron|SMARCA4_ENST00000541122.2_Intron|SMARCA4_ENST00000450717.3_Intron|SMARCA4_ENST00000444061.3_Intron	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1389					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACACGTGCGTCAAAGGTGGGG	0.527000			"""F, N, Mis"""		NSCLC								3	18					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98808818	98808818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98808818G>A	ENST00000266058.4	-	14	1604	c.1359C>T	c.(1357-1359)ttC>ttT	p.F453F	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.F453F	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	453	LRRCT 2.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TGGTGCGCAGGAAGTCTGCCA	0.587000													26	77					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62744636	62744636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62744636C>T	ENST00000377871.3	-	9	1851	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	SLC22A6_ENST00000458333.2_Intron|SLC22A6_ENST00000421062.2_Missense_Mutation_p.E485K|SLC22A6_ENST00000360421.4_Intron	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	529					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						atccctgcttctttctgagTG	0.607000													19	173					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43259928	43259928	+	Silent	SNP	G	G	A	rs140077118		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43259928G>A	ENST00000422911.1	-	7	887	c.786C>T	c.(784-786)agC>agT	p.S262S	PRDM15_ENST00000269844.3_Silent_p.S591S|PRDM15_ENST00000538201.1_Silent_p.S225S|PRDM15_ENST00000398548.1_Silent_p.S262S|PRDM15_ENST00000447207.2_Silent_p.S225S			P57071	PRD15_HUMAN	PR domain containing 15	591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CTGGAGGAAGGCTTTTGGCTT	0.602000													42	134					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228469732	228469732	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228469732G>A	ENST00000570156.2	+	36	9657	c.9583G>A	c.(9583-9585)Gac>Aac	p.D3195N	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Missense_Mutation_p.D2766N|OBSCN_ENST00000359599.6_Missense_Mutation_p.D1613N|OBSCN_ENST00000284548.11_Missense_Mutation_p.D2766N|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2195	Ig-like 32.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GAGTGCCAGCGACCCGGCCAT	0.617000													18	25					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114136107	114136107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:114136107G>A	ENST00000356116.1	+	1	152	c.40G>A	c.(40-42)Gag>Aag	p.E14K	ACSL5_ENST00000354273.4_5'UTR|ACSL5_ENST00000433418.1_5'UTR|ACSL5_ENST00000354655.4_Intron|ACSL5_ENST00000479936.1_Intron|ACSL5_ENST00000393081.1_Intron	NM_016234.3	NP_057318.2	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	0					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GAGGAACCACGAGCGAGGGAA	0.632000													42	101					0	0	1	0	0
TRBV5-6	28609	broad.mit.edu	37	7	142131517	142131517	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142131517G>A	ENST00000390375.2	-	0	278																											AATCGATCAGGGAAGTTGCCT	0.537000													28	76					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71163622	71163622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71163622C>T	ENST00000393567.2	-	9	1298	c.1148G>A	c.(1147-1149)cGa>cAa	p.R383Q	HYDIN_ENST00000538248.1_Missense_Mutation_p.R410Q|HYDIN_ENST00000321489.5_Missense_Mutation_p.R383Q|HYDIN_ENST00000288168.10_Missense_Mutation_p.R400Q|HYDIN_ENST00000448691.1_Missense_Mutation_p.R383Q|HYDIN_ENST00000541601.1_Missense_Mutation_p.R400Q|HYDIN_ENST00000448089.2_Missense_Mutation_p.R383Q|HYDIN_ENST00000393550.2_Missense_Mutation_p.R383Q	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	383										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CGCAAAGGTTCGGGACAGAAC	0.443000													15	31					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162875326	162875326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:162875326G>A	ENST00000360534.3	-	16	1893	c.1333C>T	c.(1333-1335)Ctc>Ttc	p.L445F		NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	445					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	TCACAACTGAGGCATGTCACT	0.403000													32	83					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75108723	75108723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75108723G>A	ENST00000326665.5	-	4	521	c.303C>T	c.(301-303)atC>atT	p.I101I		NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	101										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TAAACCTCTGGATTCGCTCCT	0.338000													28	73					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41015551	41015551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41015551C>T	ENST00000399564.4	-	29	3364	c.2914G>A	c.(2914-2916)Ggt>Agt	p.G972S	MROH2B_ENST00000506092.2_Missense_Mutation_p.G527S	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TCCTGCAAACCCTGCAGTCTT	0.413000													19	53					0	0	1	0	0
CCDC114	93233	broad.mit.edu	37	19	48800737	48800737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48800737C>T	ENST00000315396.7	-	14	2191	c.1509G>A	c.(1507-1509)aaG>aaA	p.K503K		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	503										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CGGCCAGGTCCTTCTGGCGCT	0.736000													4	20					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40438554	40438554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40438554G>A	ENST00000381793.2	-	4	1630	c.1234C>T	c.(1234-1236)Cat>Tat	p.H412Y	RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381795.6_Intron|RBM47_ENST00000514014.1_Missense_Mutation_p.H374Y|RBM47_ENST00000295971.7_Missense_Mutation_p.H412Y|RBM47_ENST00000319592.4_Intron			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	412						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						TTCCCTTCATGATATCGGCTA	0.522000													19	238					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83331569	83331569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83331569C>T	ENST00000261722.3	-	22	2860	c.2653G>A	c.(2653-2655)Gat>Aat	p.D885N	AP3B2_ENST00000535359.1_Missense_Mutation_p.D904N|RP11-752G15.3_ENST00000560650.1_RNA|AP3B2_ENST00000535348.1_Missense_Mutation_p.D853N	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	885					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			ATGTGGGGATCCCCGGAGAAA	0.622000													21	15					0	0	1	0	0
GRWD1	83743	broad.mit.edu	37	19	48956279	48956279	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48956279C>A	ENST00000253237.5	+	7	1571	c.1338C>A	c.(1336-1338)gtC>gtA	p.V446V		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	446						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		CCATCAGCGTCTGAGGCGTCC	0.602000													14	54					1.52009e-12	1.52748e-12	1	1	0
TOP1MT	116447	broad.mit.edu	37	8	144408461	144408461	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144408461G>A	ENST00000523676.1	-	5	525	c.120C>T	c.(118-120)ttC>ttT	p.F40F	TOP1MT_ENST00000521193.1_Silent_p.F40F|TOP1MT_ENST00000329245.4_Silent_p.F138F|TOP1MT_ENST00000519148.1_Silent_p.F40F			Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	138					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	GGATCTCCGTGAAGTCACACT	0.557000													62	103					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170066148	170066148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170066148C>T	ENST00000263816.3	-	38	6569	c.6284G>A	c.(6283-6285)cGa>cAa	p.R2095Q		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2095					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.R2095Q(2)		biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAGTGCGTTTCGTCCTGGAAG	0.413000													13	48					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979735	12979735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12979735G>A	ENST00000361079.2	+	4	1010	c.927G>A	c.(925-927)ttG>ttA	p.L309L						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGTCGGACTTGAAGCATCTCT	0.567000													14	138					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13742516	13742516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:13742516C>T	ENST00000383314.2	+	8	1244	c.1004C>T	c.(1003-1005)tCa>tTa	p.S335L	RNMT_ENST00000592764.1_Missense_Mutation_p.S335L|RNMT_ENST00000589866.1_Missense_Mutation_p.S335L|RNMT_ENST00000262173.3_Missense_Mutation_p.S335L|RNMT_ENST00000543302.2_Missense_Mutation_p.S335L|RNMT_ENST00000535051.1_Missense_Mutation_p.S93L			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	335					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						GAAACAGAATCATTTGGAAAT	0.328000													40	82					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559123	140559123	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140559123C>T	ENST00000239444.2	+	1	1753	c.1508C>T	c.(1507-1509)tCc>tTc	p.S503F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		503	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCTCGCCTCCCTGGTCTCC	0.667000													59	314					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125015581	125015581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125015581G>A	ENST00000522917.1	+	13	1900	c.1694G>A	c.(1693-1695)gGg>gAg	p.G565E	FER1L6_ENST00000399018.1_Missense_Mutation_p.G565E|FER1L6-AS1_ENST00000518567.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	565						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTGACAGAAGGGAACAGGTAG	0.502000													11	39					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111870807	111870807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111870807C>T	ENST00000305815.5	-	28	3673	c.3421G>A	c.(3421-3423)Gga>Aga	p.G1141R	SLC9C1_ENST00000487372.1_Missense_Mutation_p.G1093R	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	1141					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										CTGTGTGCTCCATCCTGGGAT	0.522000													26	40					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15065098	15065098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15065098G>A	ENST00000430939.2	-	7	1150	c.1021C>T	c.(1021-1023)Ctg>Ttg	p.L341L	SLC1A6_ENST00000221742.3_Silent_p.L405L|SLC1A6_ENST00000600144.1_Silent_p.L327L			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	405					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	TCCACACCCAGGCCCTCCTCC	0.687000													33	60					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229235	21229235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21229235C>T	ENST00000233242.1	-	26	10632	c.10505G>A	c.(10504-10506)gGt>gAt	p.G3502D		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3502	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAGAACCGAACCCTTGACATC	0.468000													47	101					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70946680	70946680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70946680G>A	ENST00000334414.6	-	21	5308	c.5264C>T	c.(5263-5265)cCt>cTt	p.P1755L	PTPRB_ENST00000550857.1_Missense_Mutation_p.P1447L|PTPRB_ENST00000451516.2_Missense_Mutation_p.P1447L|PTPRB_ENST00000550358.1_Missense_Mutation_p.P1667L|PTPRB_ENST00000538708.1_Missense_Mutation_p.P1447L|PTPRB_ENST00000261266.5_Missense_Mutation_p.P1537L	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1537	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTTGCTGTTAGGATTTTCGGC	0.468000													28	93					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427031	135427031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135427031C>T	ENST00000394143.1	+	6	1457	c.1166C>T	c.(1165-1167)tCa>tTa	p.S389L	GPR112_ENST00000370652.1_Missense_Mutation_p.S389L|GPR112_ENST00000287534.4_Missense_Mutation_p.S326L|GPR112_ENST00000394141.1_Missense_Mutation_p.S184L|GPR112_ENST00000412101.1_Missense_Mutation_p.S184L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	389					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TCTACAACTTCAGCAATTAAA	0.368000													48	29					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916457	42916457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42916457C>T	ENST00000316161.4	-	1	1176	c.852G>A	c.(850-852)caG>caA	p.Q284Q	ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.Q284Q	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	284					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCGTGTTCCCCTGGGAGGCCC	0.582000													8	17					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43268903	43268903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43268903G>A	ENST00000372585.5	+	6	953	c.858G>A	c.(856-858)ctG>ctA	p.L286L	SLC22A7_ENST00000372589.3_Silent_p.L284L|SLC22A7_ENST00000372574.3_Silent_p.L284L|SLC22A7_ENST00000487175.1_3'UTR	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	286						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GCTGGCTTCTGACCCAAGGCC	0.572000													35	69					0	0	1	0	0
WDR45B	56270	broad.mit.edu	37	17	80579640	80579640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80579640G>A	ENST00000392325.4	-	6	657	c.463C>T	c.(463-465)Ctc>Ttc	p.L155F	WDR45B_ENST00000571835.1_5'UTR	NM_019613.3	NP_062559.2			WD repeat domain 45B																		AAGGCCAGGAGGGAGTTGTTA	0.567000													11	35					0	0	1	0	0
ZNF549	256051	broad.mit.edu	37	19	58049491	58049491	+	Silent	SNP	C	C	T	rs138206012		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58049491C>T	ENST00000376233.3	+	4	1300	c.1119C>T	c.(1117-1119)tcC>tcT	p.S373S	ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000240719.3_Silent_p.S360S|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTATTCATTCCTATGACCGCA	0.443000													24	59					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169696962	169696962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169696962C>T	ENST00000333360.7	-	9	1525	c.1386G>A	c.(1384-1386)gaG>gaA	p.E462E	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367775.1_Silent_p.E337E|SELE_ENST00000367774.1_Intron|SELE_ENST00000367782.4_Intron|SELE_ENST00000367779.4_Intron|SELE_ENST00000367781.4_Silent_p.E399E|SELE_ENST00000367777.1_Intron|SELE_ENST00000367776.1_Silent_p.E399E|SELE_ENST00000367780.4_Silent_p.E337E	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	462	Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					CAAATCCCTCCTCACAGCTGA	0.502000													33	118					0	0	1	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73490866	73490866	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:73490866A>C	ENST00000556143.1	-	2	1071	c.351T>G	c.(349-351)ccT>ccG	p.P117P	ZFYVE1_ENST00000318876.5_Silent_p.P117P|ZFYVE1_ENST00000553891.1_Silent_p.P117P	NM_021260.2	NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	117						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		ACACAGTAACAGGGTGTCTCC	0.483000													94	236					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46915458	46915458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46915458C>T	ENST00000307522.3	-	1	1383	c.610G>A	c.(610-612)Ggg>Agg	p.G204R		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	204						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		TTCAGCTTCCCCCAGGACACC	0.697000													14	21					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916520	42916520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42916520C>T	ENST00000316161.4	-	1	1113	c.789G>A	c.(787-789)agG>agA	p.R263R	ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.R263R	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	263					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCCCCTGCTCCCTCAGAAACT	0.582000													8	19					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158524020	158524020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:158524020C>T	ENST00000313708.6	-	2	535	c.253G>A	c.(253-255)Gag>Aag	p.E85K	EBF1_ENST00000517373.1_Missense_Mutation_p.E85K|EBF1_ENST00000380654.4_Missense_Mutation_p.E85K|EBF1_ENST00000518836.1_5'UTR	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	85					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTGTCCTCTCGATCTCCACG	0.627000			T	HMGA2	lipoma								4	30					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150443463	150443463	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150443463C>T	ENST00000401000.4	+	10	2026	c.1961C>T	c.(1960-1962)cCt>cTt	p.P654L	RPRD2_ENST00000369068.4_Missense_Mutation_p.P680L|RPRD2_ENST00000539519.1_Missense_Mutation_p.P654L|RPRD2_ENST00000492220.1_3'UTR			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	680	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						AAAGGTAATCCTGGTTTCAGT	0.507000													29	64					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981797	61981797	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61981797G>A	ENST00000370263.4	-	5	1187	c.966C>T	c.(964-966)gtC>gtT	p.V322V	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	322					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AGACCGTGATGACGATGGACA	0.607000													35	82					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79418033	79418033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79418033C>T	ENST00000264895.6	+	60	9473	c.9033C>T	c.(9031-9033)ggC>ggT	p.G3011G		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3006					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCTACCTCGGCCTTCCTCTTG	0.453000													37	128					0	0	1	0	0
SLC9C1	285335	broad.mit.edu	37	3	111981908	111981908	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111981908G>A	ENST00000305815.5	-	10	1312	c.1060C>T	c.(1060-1062)Cga>Tga	p.R354*	SLC9C1_ENST00000487372.1_Nonsense_Mutation_p.R306*	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	354					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										TGACCAACTCGAGACAAAACA	0.373000													38	94					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234858655	234858655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234858655C>T	ENST00000324695.4	+	9	1045	c.1005C>T	c.(1003-1005)atC>atT	p.I335I	AC005538.5_ENST00000455991.1_RNA|TRPM8_ENST00000433712.2_Silent_p.I23I	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	335						integral to membrane		p.I335I(1)		breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CGGGCCAGATCGCTGATGTGA	0.552000													18	42					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100130033	100130033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100130033G>A	ENST00000394897.1	-	6	702	c.620C>T	c.(619-621)tCt>tTt	p.S207F	ADH6_ENST00000394899.2_Missense_Mutation_p.S207F|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000237653.7_Missense_Mutation_p.S207F|ADH6_ENST00000407820.2_5'UTR|ADH6_ENST00000504257.1_5'UTR|RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	207					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	CATGACAACAGACAAGCCGAC	0.473000													39	274					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8531250	8531250	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8531250C>T	ENST00000348943.3	+	8	877	c.645C>T	c.(643-645)tcC>tcT	p.S215S	HNRNPM_ENST00000325495.4_Silent_p.S254S	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	254	RRM 2.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						TTGAACAGTCCATTGAAGCTG	0.398000													51	135					0	0	1	0	0
TEX13B	56156	broad.mit.edu	37	X	107224759	107224759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107224759C>T	ENST00000302917.1	-	3	582	c.490G>A	c.(490-492)Gct>Act	p.A164T		NM_031273.2	NP_112563.1	Q9BXU2	TX13B_HUMAN	testis expressed 13B	164										breast(1)|endometrium(5)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28						AACACTGTAGCCTGGCCCTGT	0.642000													58	48					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240871	3240871	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3240871G>A	ENST00000217939.6	-	5	3009	c.2855C>T	c.(2854-2856)tCa>tTa	p.S952L		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	952						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGGCTCTGGTGACGATCCAAC	0.507000													17	28					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62239438	62239438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:62239438G>A	ENST00000261517.5	-	43	4903	c.4830C>T	c.(4828-4830)gtC>gtT	p.V1610V	VPS13C_ENST00000249837.3_Silent_p.V1567V|VPS13C_ENST00000395898.3_Silent_p.V1567V|VPS13C_ENST00000395896.4_Silent_p.V1610V	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	1610					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						CACAGACAAAGACATTAAATG	0.308000													51	151					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148809282	148809282	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148809282G>A	ENST00000378061.2	-	3	383	c.251C>T	c.(250-252)cCt>cTt	p.P84L	ZNF425_ENST00000484196.1_5'UTR	NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	84					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.P84H(1)		breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			ATCAGTAGGAGGGCTAGTTGT	0.378000													16	201					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150163996	150163996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150163996C>T	ENST00000307271.3	+	2	784	c.210C>T	c.(208-210)ttC>ttT	p.F70F		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	70						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CTGACCTTTTCTCCTCAATAG	0.493000													69	137					0	0	1	0	0
GLT8D2	83468	broad.mit.edu	37	12	104387256	104387256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104387256C>T	ENST00000360814.4	-	10	1199	c.794G>A	c.(793-795)gGa>gAa	p.G265E	GLT8D2_ENST00000548660.1_Missense_Mutation_p.G265E|GLT8D2_ENST00000546436.1_Missense_Mutation_p.G265E	NM_031302.3	NP_112592.1	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	265						integral to membrane	transferase activity, transferring glycosyl groups			kidney(3)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						CACCCCTCCTCCCAGGGAGCT	0.458000													5	41					0	0	1	0	0
HOXB13	10481	broad.mit.edu	37	17	46805604	46805604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46805604C>T	ENST00000290295.7	-	1	936	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	118					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GGGTACTCTTCCCCGGCCGTG	0.652000													51	99					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9086960	9086960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9086960C>T	ENST00000397910.4	-	1	5058	c.4855G>A	c.(4855-4857)Gag>Aag	p.E1619K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1619	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGCCAGTCTCAATCTCTCTG	0.512000													56	143					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114304291	114304291	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114304291G>A	ENST00000309235.5	+	6	1234	c.1076G>A	c.(1075-1077)cGg>cAg	p.R359Q	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	359					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GAAAAGTCACGGAAATCTAAT	0.438000													40	66					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131908343	131908343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131908343G>A	ENST00000359827.3	-	9	3002	c.2040C>T	c.(2038-2040)gtC>gtT	p.V680V	PLXNA4_ENST00000321063.4_Silent_p.V680V			Q9HCM2	PLXA4_HUMAN	plexin A4	680	PSI 2.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CATGGGTGCAGACATGCCGGT	0.587000													8	22					0	0	1	0	0
PEX13	5194	broad.mit.edu	37	2	61275754	61275754	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:61275754C>T	ENST00000295030.4	+	4	1099	c.1061C>T	c.(1060-1062)tCt>tTt	p.S354F		NM_002618.3	NP_002609.1	Q92968	PEX13_HUMAN	peroxisomal biogenesis factor 13	354					cerebral cortex cell migration|fatty acid alpha-oxidation|locomotory behavior|microtubule-based peroxisome localization|neuron migration|protein import into peroxisome matrix, docking|suckling behavior	integral to peroxisomal membrane|membrane fraction	protein binding			endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10			LUSC - Lung squamous cell carcinoma(5;2.05e-06)|Lung(5;3.13e-05)|Epithelial(17;0.114)			CAGCAACAATCTTTTACCAAC	0.383000													27	99					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175048558	175048558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175048558G>A	ENST00000239462.4	+	3	612	c.499G>A	c.(499-501)Gag>Aag	p.E167K		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	167	EGF-like 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCCCGCCTGCGAGCGGCTGGC	0.731000													4	9					0	0	1	0	0
SULT2A1	6822	broad.mit.edu	37	19	48374717	48374717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48374717C>T	ENST00000222002.3	-	6	992	c.853G>A	c.(853-855)Gaa>Aaa	p.E285K		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	285					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		GGACGTTATTCCCATGGGAAC	0.428000													22	77					0	0	1	0	0
FTMT	94033	broad.mit.edu	37	5	121187759	121187759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121187759C>T	ENST00000321339.1	+	1	110	c.101C>T	c.(100-102)cCg>cTg	p.P34L		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	34					cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		CGTTGGGCCCCGGGGCGCCCC	0.766000													11	16					0	0	1	0	0
HHATL	57467	broad.mit.edu	37	3	42739655	42739655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42739655G>A	ENST00000441594.1	-	6	933	c.672C>T	c.(670-672)acC>acT	p.T224T	HHATL_ENST00000310417.5_Silent_p.T224T	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	224					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		AGCGATCAAAGGTCATGATGG	0.527000													33	62					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44575962	44575962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44575962C>T	ENST00000289547.4	-	4	1802	c.1747G>A	c.(1747-1749)Gac>Aac	p.D583N	NPC1L1_ENST00000423141.1_Missense_Mutation_p.D583N|NPC1L1_ENST00000381160.3_Missense_Mutation_p.D583N|NPC1L1_ENST00000546276.1_Missense_Mutation_p.D583N	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	583					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AGACGGGGGTCCCCGGCAGGG	0.567000													28	70					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125284948	125284948	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125284948C>T	ENST00000431078.1	+	10	1925	c.1561C>T	c.(1561-1563)Cag>Tag	p.Q521*		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	521	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TATTGATAACCAGCCCAAGGA	0.443000													31	77					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71705447	71705447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71705447G>A	ENST00000356340.3	+	35	2492	c.1956G>A	c.(1954-1956)ggG>ggA	p.G652G	COL13A1_ENST00000398968.3_Silent_p.G633G|COL13A1_ENST00000520133.1_Silent_p.G574G|COL13A1_ENST00000398966.3_Silent_p.G630G|COL13A1_ENST00000398969.3_Silent_p.G580G|COL13A1_ENST00000398974.3_Silent_p.G640G|COL13A1_ENST00000398972.3_Silent_p.G638G|COL13A1_ENST00000398973.3_Silent_p.G626G|COL13A1_ENST00000398971.3_Silent_p.G637G|COL13A1_ENST00000520267.1_Silent_p.G580G|COL13A1_ENST00000398964.3_Silent_p.G623G|COL13A1_ENST00000357811.3_Silent_p.G618G|COL13A1_ENST00000354547.3_Silent_p.G630G|COL13A1_ENST00000517713.1_Silent_p.G603G|COL13A1_ENST00000522165.1_Silent_p.G621G|COL13A1_ENST00000398978.3_Silent_p.G652G			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	652	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	GAGACCCTGGGATGACAGGAC	0.527000													7	18					0	0	1	0	0
TPST2	8459	broad.mit.edu	37	22	26936880	26936880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26936880C>T	ENST00000338754.4	-	3	987	c.717G>A	c.(715-717)gaG>gaA	p.E239E	TPST2_ENST00000403880.1_Silent_p.E239E|TPST2_ENST00000398110.2_Silent_p.E239E	NM_003595.3	NP_003586.3	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	239					peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)|large_intestine(1)|lung(5)	7						GCACCAGCTGCTCGTAGTACA	0.597000													18	51					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55594959	55594959	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55594959G>A	ENST00000378397.1	+	1	265	c.265G>A	c.(265-267)Gac>Aac	p.D89N		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				CTTTAACAAGGACAAAGCCAT	0.473000										HNSCC(27;0.073)			78	209					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18865907	18865907	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18865907C>T	ENST00000266505.7	-	6	846	c.583G>A	c.(583-585)Gga>Aga	p.G195R	PLCZ1_ENST00000541695.1_Missense_Mutation_p.G58R|PLCZ1_ENST00000542762.1_5'UTR|PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000447925.2_Missense_Mutation_p.G193R|PLCZ1_ENST00000538330.1_5'UTR|PLCZ1_ENST00000435379.1_Intron			Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	195	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					CAACGGCATCCTTTCACAAGG	0.358000													8	72					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231577	21231577	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21231577G>A	ENST00000233242.1	-	26	8290	c.8163C>T	c.(8161-8163)ttC>ttT	p.F2721F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2721				Missing (in Ref. 15; AAA51758).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGGGATTATGAATTCTGGAA	0.428000													80	190					0	0	1	0	0
PRRX2	51450	broad.mit.edu	37	9	132483027	132483027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:132483027C>T	ENST00000372469.4	+	3	827	c.600C>T	c.(598-600)ctC>ctT	p.L200L		NM_016307.3	NP_057391.1	Q99811	PRRX2_HUMAN	paired related homeobox 2	200						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|pancreas(1)	3		Ovarian(14;0.00556)				CAGATTATCTCTCCTGGACAG	0.662000													15	53					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51679045	51679045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51679045G>A	ENST00000409535.1	+	16	2581	c.2456G>A	c.(2455-2457)gGa>gAa	p.G819E	RAD54L2_ENST00000296477.3_Missense_Mutation_p.G513E	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	819	Helicase C-terminal.					nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TAAAGGGCCGGATGCTTGGGT	0.468000													16	53					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88853989	88853989	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88853989G>A	ENST00000537554.1	-	2	4567	c.1005C>T	c.(1003-1005)gcC>gcT	p.A335A	CNR1_ENST00000549890.1_Silent_p.A335A|CNR1_ENST00000468898.1_Silent_p.A302A|CNR1_ENST00000535130.1_Silent_p.A335A|CNR1_ENST00000549716.1_Silent_p.A274A|CNR1_ENST00000369501.2_Silent_p.A335A|CNR1_ENST00000428600.2_Silent_p.A335A|CNR1_ENST00000369499.2_Silent_p.A335A|CNR1_ENST00000362094.5_3'UTR	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	335					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	TGTCCATGCGGGCTTGGTCTG	0.562000													44	66					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13399748	13399748	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13399748G>A	ENST00000254508.5	-	16	2384	c.2302C>T	c.(2302-2304)Ccg>Tcg	p.P768S		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	768					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TGCAGCAGCGGACAGGACATG	0.667000													20	88					0	0	1	0	0
GPR97	222487	broad.mit.edu	37	16	57713104	57713104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57713104C>T	ENST00000333493.4	+	5	669	c.508C>T	c.(508-510)Ctg>Ttg	p.L170L	GPR97_ENST00000327655.6_5'UTR|GPR97_ENST00000450388.3_Silent_p.L50L	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	170					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCGGCTCGGCCTGGGAGATGG	0.627000													14	63					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33785099	33785099	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:33785099C>T	ENST00000261326.5	+	6	1099	c.1078C>T	c.(1078-1080)Ctg>Ttg	p.L360L		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	360					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	CTACGTGGCCCTGTCCTCTCT	0.473000													11	100					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348165	140348165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348165C>T	ENST00000289269.5	+	1	2346	c.1814C>T	c.(1813-1815)aCc>aTc	p.T605I	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		605	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACCTGGTCACCAAAGTCATA	0.517000													18	40					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46946124	46946124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46946124C>T	ENST00000429979.1	-	3	1091	c.487G>A	c.(487-489)Gac>Aac	p.D163N	KIAA0226L_ENST00000409879.2_Intron|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.D28N|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.D163N|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.D96N|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.D163N|KIAA0226L_ENST00000322896.6_Intron|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.D163N|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.D163N	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	163										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						AAAGCACTGTCAGTCTCAGGA	0.517000													9	32					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74823635	74823635	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74823635G>A	ENST00000256362.4	+	2	390	c.149G>A	c.(148-150)gGc>gAc	p.G50D		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	50					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CGGGAGGGAGGCCCTGGCCTC	0.637000													10	100					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137642657	137642657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137642657G>A	ENST00000371817.3	+	13	2005	c.1591G>A	c.(1591-1593)Gat>Aat	p.D531N		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	531	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGGTGGCGGCGATGCGGGCTC	0.637000													10	46					0	0	1	0	0
TOX3	27324	broad.mit.edu	37	16	52473859	52473859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:52473859C>T	ENST00000219746.9	-	7	1293	c.1009G>A	c.(1009-1011)Gcc>Acc	p.A337T	TOX3_ENST00000407228.3_Missense_Mutation_p.A332T	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	337					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						ATGGTCTGGGCTTCTGCTGAC	0.433000													16	48					0	0	1	0	0
MARVELD2	153562	broad.mit.edu	37	5	68737434	68737434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:68737434C>T	ENST00000325631.5	+	7	1704	c.1630C>T	c.(1630-1632)Caa>Taa	p.Q544*	MARVELD2_ENST00000413223.2_Nonsense_Mutation_p.Q428*	NM_001038603.2|NM_001244734.1	NP_001033692.2|NP_001231663.1	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2	544					sensory perception of sound	integral to membrane|tight junction				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(4)|skin(1)|urinary_tract(1)	15		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		GCAAAGAATTCAAGAATATGA	0.249000													16	50					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7569464	7569464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7569464G>A	ENST00000379802.3	+	12	1806	c.1465G>A	c.(1465-1467)Gag>Aag	p.E489K	DSP_ENST00000418664.2_Missense_Mutation_p.E489K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	489	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GGACAACAACGAGCGCAGCAA	0.527000													39	98					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34025231	34025231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34025231C>T	ENST00000374372.1	-	3	981	c.478G>A	c.(478-480)Gag>Aag	p.E160K	GDF5_ENST00000374369.3_Missense_Mutation_p.E160K			P43026	GDF5_HUMAN	growth differentiation factor 5	160					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CGAAACGGCTCCTTGGGCTCT	0.632000													24	89					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54364824	54364824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:54364824C>T	ENST00000306888.2	-	4	925	c.674G>A	c.(673-675)gGa>gAa	p.G225E	LNX1-AS1_ENST00000502373.1_RNA|FIP1L1_ENST00000507166.1_Intron|LNX1_ENST00000263925.7_Missense_Mutation_p.G321E	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	321						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AATGATGTCTCCTGGCAGTAG	0.488000													22	56					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61574598	61574598	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61574598C>T	ENST00000290866.4	+	25	3816	c.3792C>T	c.(3790-3792)ttC>ttT	p.F1264F	ACE_ENST00000413513.3_Silent_p.F649F|ACE_ENST00000577647.1_Intron|ACE_ENST00000428043.1_Intron|ACE_ENST00000490216.2_Intron|ACE_ENST00000290863.6_Silent_p.F690F|ACE_ENST00000421982.2_Silent_p.F469F	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	1264					arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TGCTGCTCTTCCTGGGCATCG	0.716000													4	9					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196883708	196883708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196883708G>A	ENST00000367416.2	+	8	1398	c.1261G>A	c.(1261-1263)Gaa>Aaa	p.E421K	CFHR4_ENST00000367418.1_Missense_Mutation_p.E175K|CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000251424.4_Missense_Mutation_p.E175K	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						ATTGGACTACGAATGCTACGA	0.393000													14	64					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115409800	115409800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115409800C>T	ENST00000369358.4	-	9	1128	c.884G>A	c.(883-885)gGc>gAc	p.G295D	NRAP_ENST00000360478.3_Missense_Mutation_p.G295D|NRAP_ENST00000369360.3_Missense_Mutation_p.G295D|NRAP_ENST00000359988.3_Missense_Mutation_p.G295D			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	295						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ACATACCTGGCCATATTGGTC	0.468000													33	184					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858500	9858500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9858500C>T	ENST00000396573.2	-	14	3210	c.2901G>A	c.(2899-2901)gtG>gtA	p.V967V	GRIN2A_ENST00000404927.2_Silent_p.V967V|GRIN2A_ENST00000562109.1_Silent_p.V967V|GRIN2A_ENST00000330684.3_Silent_p.V967V|GRIN2A_ENST00000396575.2_Silent_p.V967V|GRIN2A_ENST00000535259.1_Silent_p.V810V	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	967					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCCGGTTGGCCACAAATGTTT	0.458000													40	79					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369958	20369958	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20369958G>A	ENST00000593655.1	-	0	199																											GCTTTCTGGAGGGTCTACTAT	0.403000													19	79					0	0	1	0	0
CDR2	1039	broad.mit.edu	37	16	22358533	22358533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:22358533G>A	ENST00000268383.2	-	5	1425	c.1118C>T	c.(1117-1119)tCc>tTc	p.S373F		NM_001802.1	NP_001793.1	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2, 62kDa	373						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(48;0.0188)		GTGTGACAGGGAGTCCTGTTC	0.592000													15	79					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482341	142482341	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142482341G>A	ENST00000603901.1	+	0	721					NR_001296.3																						CTGGATTAAGGACACCATAGC	0.502000													28	106					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120989342	120989342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120989342C>T	ENST00000392793.1	+	7	1389	c.1118C>T	c.(1117-1119)tCa>tTa	p.S373L	TECTA_ENST00000264037.2_Missense_Mutation_p.S373L			O75443	TECTA_HUMAN	tectorin alpha	373	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CGCAGAGGTTCAGCCGTCTCC	0.537000													11	102					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762808	130762808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:130762808G>A	ENST00000392429.1	+	2	3619	c.1241G>A	c.(1240-1242)cGg>cAg	p.R414Q	TMEM200A_ENST00000296978.3_Missense_Mutation_p.R414Q|TMEM200A_ENST00000545622.1_Missense_Mutation_p.R414Q	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	414						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GCAGAACAACGGAAACATCCA	0.483000													27	33					0	0	1	0	0
RIMS3	9783	broad.mit.edu	37	1	41101655	41101655	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:41101655G>A	ENST00000372684.3	-	4	761	c.292C>T	c.(292-294)Cgg>Tgg	p.R98W	RIMS3_ENST00000372683.1_Missense_Mutation_p.R98W	NM_014747.2	NP_055562.2	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	98					neurotransmitter transport	cell junction|synapse		p.R98W(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			CGTGTGACCCGGCTCCGCATC	0.682000													21	50					0	0	1	0	0
PNPLA5	150379	broad.mit.edu	37	22	44280179	44280179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44280179G>A	ENST00000216177.4	-	7	1128	c.996C>T	c.(994-996)ttC>ttT	p.F332F	PNPLA5_ENST00000593866.1_Silent_p.F218F|PNPLA5_ENST00000597664.1_Silent_p.F332F|PNPLA5_ENST00000381198.2_Silent_p.F218F	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	332					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				CCGAGTGCCAGAAGCGGGCCC	0.617000											OREG0026622	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	113					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067679	9067679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9067679G>A	ENST00000397910.4	-	3	19970	c.19767C>T	c.(19765-19767)tcC>tcT	p.S6589S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6591	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTATGTTTGTGGAAGGATACA	0.453000													48	111					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124515320	124515320	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124515320G>A	ENST00000296181.4	-	10	1904	c.1608C>T	c.(1606-1608)ttC>ttT	p.F536F	ITGB5_ENST00000488466.1_5'UTR	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	536	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		ACTCGCTCTCGAAGCAGGAGC	0.602000													28	90					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2138110	2138110	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2138110C>T	ENST00000219476.3	+	40	5760	c.5130C>T	c.(5128-5130)ttC>ttT	p.F1710F	TSC2_ENST00000401874.2_Silent_p.F1643F|TSC2_ENST00000350773.4_Silent_p.F1687F|TSC2_ENST00000439673.2_Silent_p.F1607F|TSC2_ENST00000568454.1_Silent_p.F1654F|TSC2_ENST00000382538.6_Silent_p.F1595F|TSC2_ENST00000353929.4_Silent_p.F1667F	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1710	Rap-GAP.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				ACCTGCCCTTCGTGGCCCGCC	0.652000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				18	96					0	0	1	0	0
SCYL1	57410	broad.mit.edu	37	11	65293661	65293661	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65293661T>C	ENST00000524944.1	+	4	475	c.442T>C	c.(442-444)Ttc>Ctc	p.F148L	SCYL1_ENST00000270176.5_Missense_Mutation_p.F148L|SCYL1_ENST00000527630.1_Missense_Mutation_p.F148L|SCYL1_ENST00000279270.6_Missense_Mutation_p.F148L|SCYL1_ENST00000525364.1_Missense_Mutation_p.F148L|SCYL1_ENST00000533862.1_Missense_Mutation_p.F148L|SCYL1_ENST00000420247.2_Missense_Mutation_p.F148L|SCYL1_ENST00000527009.1_Missense_Mutation_p.F5L			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	148	Protein kinase.				regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			ovary(1)|skin(1)	2						GGCCGCCGTGTTCGTGGACCG	0.637000													19	43					0	0	1	0	0
MIR329-2	574409	broad.mit.edu	37	14	101493518	101493518	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101493518C>T	ENST00000385029.1	+	0	82					NR_029968.1																						TTTCCAGTATCAAATCCCATC	0.463000													38	128					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	16021923	16021923	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:16021923G>A	ENST00000217246.4	+	16	1626	c.1231_splice	c.e16+1	p.A411_splice	MACROD2_ENST00000402914.1_Splice_Site_p.V176_splice|MACROD2_ENST00000310348.4_Splice_Site_p.V411_splice|MACROD2_ENST00000378058.3_Splice_Site_p.V176_splice|MACROD2_ENST00000407045.3_Splice_Site_p.V62_splice	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	434										breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				AGGTCCTGATGGTAAGGTTCT	0.443000													18	26					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129419523	129419523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:129419523C>T	ENST00000421865.2	+	4	651	c.602C>T	c.(601-603)tCa>tTa	p.S201L		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	201	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATCTGCACTTCATTTTACTCC	0.433000													38	46					0	0	1	0	0
NR4A1	3164	broad.mit.edu	37	12	52451249	52451249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52451249C>T	ENST00000545748.1	+	7	2632	c.1637C>T	c.(1636-1638)tCc>tTc	p.S546F	NR4A1_ENST00000360284.3_Missense_Mutation_p.S505F|NR4A1_ENST00000550082.1_Missense_Mutation_p.S505F|NR4A1_ENST00000394824.2_Missense_Mutation_p.S492F|NR4A1_ENST00000243050.1_Missense_Mutation_p.S492F|NR4A1_ENST00000394825.1_Missense_Mutation_p.S492F			P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	492					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)	16				BRCA - Breast invasive adenocarcinoma(357;0.0967)		TTCTCAAGGTCCCTGCACAGC	0.602000													10	58					0	0	1	0	0
RHOT1	55288	broad.mit.edu	37	17	30503006	30503006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:30503006C>T	ENST00000358365.3	+	5	475	c.248C>T	c.(247-249)gCc>gTc	p.A83V	RHOT1_ENST00000581094.1_Missense_Mutation_p.A83V|RHOT1_ENST00000354266.3_Missense_Mutation_p.A62V|RHOT1_ENST00000333942.6_Missense_Mutation_p.A83V|RHOT1_ENST00000394692.2_Missense_Mutation_p.A83V|RHOT1_ENST00000545287.2_Missense_Mutation_p.A83V|RHOT1_ENST00000583994.1_5'UTR|RHOT1_ENST00000580976.1_Intron	NM_001033568.1	NP_001028740.1	Q8IXI2	MIRO1_HUMAN	ras homolog family member T1	83	Miro 1.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			NS(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				ATAGTGTATGCCGTTAACAAC	0.308000													7	25					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181708304	181708304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181708304C>T	ENST00000526775.1	+	24	3742	c.3577C>T	c.(3577-3579)Ctg>Ttg	p.L1193L	CACNA1E_ENST00000367567.4_Silent_p.L819L|CACNA1E_ENST00000358338.5_Silent_p.L1144L|CACNA1E_ENST00000367570.1_Silent_p.L1212L|CACNA1E_ENST00000360108.3_Silent_p.L1193L|CACNA1E_ENST00000367573.2_Silent_p.L1212L|CACNA1E_ENST00000357570.5_Silent_p.L1163L	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1212					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGGCTTGATCCTGCAGGATGG	0.512000													46	130					0	0	1	0	0
STX5	6811	broad.mit.edu	37	11	62574950	62574950	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62574950G>A	ENST00000294179.3	-	11	1212	c.1059C>T	c.(1057-1059)ttC>ttT	p.F353F	STX5_ENST00000377897.4_3'UTR|STX5_ENST00000394690.1_Silent_p.F299F|STX5_ENST00000541317.1_Silent_p.F257F	NM_001244666.1|NM_003164.4	NP_001231595.1|NP_003155.2	Q13190	STX5_HUMAN	syntaxin 5	353					intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			breast(2)|endometrium(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	18						TTCAAGCAAGGAAGACCACAA	0.527000													5	29					0	0	1	0	0
DPYSL3	1809	broad.mit.edu	37	5	146780333	146780333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:146780333C>T	ENST00000343218.5	-	10	1571	c.1374G>A	c.(1372-1374)ggG>ggA	p.G458G	DPYSL3_ENST00000398514.3_Silent_p.G344G|DPYSL3_ENST00000534907.1_Intron	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	344					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGTCCTTCCCAATTGCTT	0.557000													20	55					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36330510	36330510	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36330510C>T	ENST00000378910.5	-	21	2815		c.e21-1		NPHS1_ENST00000353632.6_Splice_Site	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)						cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCAGGGCGGCCTATGGGGAGA	0.502000													17	70					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161821579	161821579	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161821579C>T	ENST00000367942.3	+	11	1454	c.1387C>T	c.(1387-1389)Cct>Tct	p.P463S	ATF6_ENST00000476437.1_3'UTR	NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	463	Poly-Pro.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GCTTTACATTCCTCCACCTCC	0.398000													77	200					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23065576	23065576	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23065576G>A	ENST00000246006.4	-	1	1401	c.1254C>T	c.(1252-1254)gcC>gcT	p.A418A		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	418	EGF-like 4; calcium-binding (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGTCCTCCCCGGCCAGGACGT	0.632000													35	64					0	0	1	0	0
KRT17	3872	broad.mit.edu	37	17	39780712	39780712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39780712G>A	ENST00000311208.8	-	1	117	c.50C>T	c.(49-51)tCc>tTc	p.S17F	JUP_ENST00000540235.1_Intron	NM_000422.2	NP_000413.1	Q04695	K1C17_HUMAN	keratin 17	17	Head.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	12		Breast(137;0.000307)				CAGGCCGGAGGAGCCCTTGAT	0.716000													9	13					0	0	1	0	0
CCT3	7203	broad.mit.edu	37	1	156294849	156294849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156294849G>A	ENST00000295688.3	-	6	616	c.336C>T	c.(334-336)ttC>ttT	p.F112F	CCT3_ENST00000368259.2_Silent_p.F74F|CCT3_ENST00000368261.3_Silent_p.F67F|CCT3_ENST00000472765.2_Silent_p.F67F	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	112					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					GCTGCTCCAGGAAGTGCTCAG	0.428000													15	69					0	0	1	0	0
CDH1	999	broad.mit.edu	37	16	68842665	68842665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68842665C>T	ENST00000261769.5	+	5	792	c.601C>T	c.(601-603)Cct>Tct	p.P201S	CDH1_ENST00000422392.2_Missense_Mutation_p.P201S|CDH1_ENST00000562836.1_3'UTR	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	201	Cadherin 1.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(2)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TGACACACCCCCTGTTGGTGT	0.413000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				16	49					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	43990966	43990966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43990966G>A	ENST00000292140.5	-	11	1666	c.1306C>T	c.(1306-1308)Ctc>Ttc	p.L436F		NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	436										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				AGCTGGTAGAGGGGGTATCTG	0.612000													3	19					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56345178	56345178	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56345178G>A	ENST00000262290.4	+	13	2278	c.1962G>A	c.(1960-1962)acG>acA	p.T654T	LPO_ENST00000582328.1_Silent_p.T571T|LPO_ENST00000543544.1_Silent_p.T595T|LPO_ENST00000421678.2_Silent_p.T571T	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	654					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						GGGTCTTCACGAACGAGCAGA	0.572000													21	50					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38990427	38990427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:38990427C>T	ENST00000318792.1	+	2	231	c.221C>T	c.(220-222)tCc>tTc	p.S74F		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	74										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		GAAGATGCTTCCCTTCTCTTC	0.507000													20	50					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42858582	42858582	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:42858582G>A	ENST00000455697.1	-	7	1539	c.1254C>T	c.(1252-1254)ctC>ctT	p.L418L	RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000552240.1_Silent_p.L418L|PRICKLE1_ENST00000445766.2_Silent_p.L418L|PRICKLE1_ENST00000345127.3_Silent_p.L418L|PRICKLE1_ENST00000548696.1_Silent_p.L418L	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	418					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		ACTTGAGGAGGAGCTGCGTCA	0.438000													6	38					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197073649	197073649	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197073649G>A	ENST00000367409.4	-	18	4988	c.4732C>T	c.(4732-4734)Cga>Tga	p.R1578*	ASPM_ENST00000367408.1_Intron|ASPM_ENST00000294732.7_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1578					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TTTAAAAATCGAACTCTGTCT	0.338000													19	72					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41062005	41062005	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41062005G>A	ENST00000352632.3	+	25	5186	c.5100G>A	c.(5098-5100)cgG>cgA	p.R1700R	SPTBN4_ENST00000392023.1_Silent_p.R376R|SPTBN4_ENST00000392025.1_Silent_p.R443R|SPTBN4_ENST00000595535.1_Silent_p.R1700R|SPTBN4_ENST00000598249.1_Silent_p.R1700R|SPTBN4_ENST00000338932.3_Silent_p.R1700R			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1700					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGATCAGCCGGCGGCAGTCTC	0.662000													4	23					0	0	1	0	0
KLHL38	340359	broad.mit.edu	37	8	124664732	124664732	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124664732G>A	ENST00000325995.7	-	1	458	c.435C>T	c.(433-435)atC>atT	p.I145I	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	145	BACK.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						CGCAGCTTAAGATTTCTGAGA	0.582000													20	51					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25890625	25890625	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:25890625G>A	ENST00000520164.1	-	6	1064	c.527C>T	c.(526-528)cCa>cTa	p.P176L	EBF2_ENST00000408929.3_Missense_Mutation_p.P28L	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	176					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		TGGGTCCGATGGAGTCTCATT	0.388000													8	120					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101835746	101835746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101835746G>A	ENST00000370418.3	-	2	593	c.342C>T	c.(340-342)atC>atT	p.I114I		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	114	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TGAGCTGGACGATGCGCTGGT	0.612000													24	66					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6260441	6260441	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6260441G>A	ENST00000379936.2	+	1	120	c.5G>A	c.(4-6)aGc>aAc	p.S2N	CNGA4_ENST00000533426.1_Intron	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	2					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAACCATGAGCCAGGACACC	0.577000													27	65					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77290690	77290690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77290690G>A	ENST00000388914.3	-	10	1388	c.1236C>T	c.(1234-1236)atC>atT	p.I412I		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	412										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						GGTCAATGGTGATGCTGTTGC	0.557000													6	84					0	0	1	0	0
PABPC3	5042	broad.mit.edu	37	13	25671151	25671151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25671151G>A	ENST00000281589.3	+	1	852	c.815G>A	c.(814-816)cGg>cAg	p.R272Q		NM_030979.2	NP_112241.2	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	272					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding	p.R272Q(1)		breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|pancreas(1)|skin(3)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAAGTGGAACGGCAGACGGAA	0.398000													49	136					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59221482	59221482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59221482G>A	ENST00000262717.4	+	12	2358	c.1960G>A	c.(1960-1962)Gac>Aac	p.D654N	CDH20_ENST00000536675.2_Missense_Mutation_p.D654N|CDH20_ENST00000538374.1_Missense_Mutation_p.D654N			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	654					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				CATCATCGACGACGAGGAAAA	0.577000													47	147					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8007490	8007490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8007490G>A	ENST00000380149.1	-	13	2226	c.2196C>T	c.(2194-2196)ttC>ttT	p.F732F	ALOXE3_ENST00000448843.2_Silent_p.F576F|ALOXE3_ENST00000318227.3_Silent_p.F708F			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	576					leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						TTGCAGTGAGGAACTTCACCA	0.582000													11	17					0	0	1	0	0
OSR2	116039	broad.mit.edu	37	8	99961684	99961684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:99961684G>A	ENST00000297565.4	+	2	1000	c.504G>A	c.(502-504)acG>acA	p.T168T	OSR2_ENST00000457907.2_Silent_p.T289T|OSR2_ENST00000522510.1_Silent_p.T168T|OSR2_ENST00000435298.2_Silent_p.T168T|OSR2_ENST00000523368.1_Silent_p.T168T	NM_001142462.1	NP_001135934.1	Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	168					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CCTCCAAAACGAAAAAAGAGT	0.522000													73	232					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57407426	57407426	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:57407426C>A	ENST00000374900.4	+	7	1080	c.960C>A	c.(958-960)tcC>tcA	p.S320S		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	320						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						TTTTAATGTCCAAAGTGGACC	0.303000										HNSCC(52;0.14)			49	26					3.39706e-21	3.41851e-21	1	1	0
ZNF615	284370	broad.mit.edu	37	19	52497354	52497354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52497354G>A	ENST00000602063.1	-	6	1324	c.975C>T	c.(973-975)ttC>ttT	p.F325F	ZNF615_ENST00000594083.1_Silent_p.F336F|ZNF615_ENST00000376716.5_Silent_p.F325F|ZNF615_ENST00000391795.3_Silent_p.F330F|ZNF615_ENST00000598071.1_Silent_p.F336F			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		ACTTTGTAGAGAAGGCCTTCC	0.423000													18	163					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87614323	87614323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87614323G>A	ENST00000327946.7	-	8	1248	c.1163C>T	c.(1162-1164)tCg>tTg	p.S388L		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	388						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	ATAGGGATTCGAACTGTCCTC	0.493000										Multiple Myeloma(13;0.14)			27	64					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196774900	196774900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196774900G>A	ENST00000312428.6	-	25	4055	c.3955C>T	c.(3955-3957)Cat>Tat	p.H1319Y		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1319	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AGGTGCAAATGAAGGGCTCCA	0.398000													9	25					0	0	1	0	0
EXD3	54932	broad.mit.edu	37	9	140267448	140267448	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140267448G>A	ENST00000340951.4	-	5	566	c.371C>T	c.(370-372)cCa>cTa	p.P124L	EXD3_ENST00000479452.1_Missense_Mutation_p.P124L|EXD3_ENST00000475006.1_5'UTR|EXD3_ENST00000342129.4_5'UTR	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	124					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						GCTGGCCAGTGGTGCCGCAAG	0.642000													11	57					0	0	1	0	0
MVB12B	89853	broad.mit.edu	37	9	129143376	129143376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:129143376C>T	ENST00000361171.3	+	3	319	c.238C>T	c.(238-240)Ctc>Ttc	p.L80F	MVB12B_ENST00000545391.1_Missense_Mutation_p.L80F|MVB12B_ENST00000535766.1_Missense_Mutation_p.L73F|MVB12B_ENST00000436593.3_Missense_Mutation_p.L65F	NM_033446.2	NP_258257.1			multivesicular body subunit 12B																		GGATGCTGACCTCTGGAAAGA	0.463000													37	63					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4947743	4947743	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4947743C>T	ENST00000345988.2	-	9	994	c.905G>A	c.(904-906)tGg>tAg	p.W302*	PPL_ENST00000590782.2_Nonsense_Mutation_p.W300*	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	302					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GTACTCCTTCCAGTCTGCGTG	0.602000													18	29					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20129011	20129011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20129011C>T	ENST00000334554.7	+	9	1224	c.1083C>T	c.(1081-1083)ttC>ttT	p.F361F	ZDHHC8_ENST00000405930.3_Silent_p.F361F|ZDHHC8_ENST00000320602.7_Silent_p.F269F|ZDHHC8_ENST00000468112.1_3'UTR	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	361						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					GGCCGGCTTTCCCCACGGGTC	0.657000													9	31					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156875149	156875149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156875149G>A	ENST00000338302.3	+	5	465	c.240G>A	c.(238-240)gtG>gtA	p.V80V	PEAR1_ENST00000292357.7_Silent_p.V80V			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	80	EMI.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTCAGGTGGTGAAGACGGACC	0.657000													8	38					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94316839	94316839	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94316839C>T	ENST00000282020.4	+	9	1585	c.1327C>T	c.(1327-1329)Cta>Tta	p.L443L	GRID2_ENST00000510992.1_Silent_p.L348L	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	443					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGGAGTGGTTCTACGTGTAGT	0.393000													33	84					0	0	1	0	0
PTGFR	5737	broad.mit.edu	37	1	78959016	78959016	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:78959016G>A	ENST00000370756.3	+	2	825	c.588G>A	c.(586-588)tgG>tgA	p.W196*	PTGFR_ENST00000370757.3_Nonsense_Mutation_p.W196*|PTGFR_ENST00000370758.1_Nonsense_Mutation_p.W196*	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	196					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	TCAAAGACTGGGAAGATAGAT	0.408000													11	114					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229771485	229771485	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:229771485C>T	ENST00000258243.2	+	4	1261	c.1125C>T	c.(1123-1125)atC>atT	p.I375I		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	375						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						TCTACAACATCGCTGCCGACA	0.522000													25	49					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32486707	32486707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:32486707C>T	ENST00000357033.4	-	23	3276	c.3070G>A	c.(3070-3072)Gaa>Aaa	p.E1024K	DMD_ENST00000378677.2_Missense_Mutation_p.E1020K	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1024					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCCTCAATTTCTTCAAATTCT	0.428000													18	11					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169049242	169049242	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169049242G>A	ENST00000359299.3	+	2	212	c.26G>A	c.(25-27)gGa>gAa	p.G9E		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	9							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		CAGGTGCAAGGAACCATCTTC	0.423000													28	36					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182156	140182156	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140182156C>T	ENST00000522353.2	+	1	1374	c.1374C>T	c.(1372-1374)tcC>tcT	p.S458S	PCDHA3_ENST00000532566.2_Silent_p.S458S|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCGCAGTCCGAGTACACGG	0.667000													51	115					0	0	1	0	0
CAPN6	827	broad.mit.edu	37	X	110494919	110494919	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:110494919C>T	ENST00000324068.1	-	6	918	c.751G>A	c.(751-753)Ggc>Agc	p.G251S	CAPN6_ENST00000541758.1_5'UTR	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	251	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						TAGGTATGGCCCTTCAGCAGA	0.448000													141	110					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	77134191	77134191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77134191G>A	ENST00000563290.1	-	5	372	c.277C>T	c.(277-279)Cct>Tct	p.P93S	SCAPER_ENST00000324767.7_Missense_Mutation_p.P93S|SCAPER_ENST00000538941.2_5'UTR			Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	92						endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						ATTTTCCGAGGGTGCCTTGTT	0.388000													10	132					0	0	1	0	0
DNAH6	1768	broad.mit.edu	37	2	84777114	84777114	+	Missense_Mutation	SNP	G	G	A	rs148362906	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:84777114G>A	ENST00000389394.3	+	9	1555	c.1418G>A	c.(1417-1419)cGa>cAa	p.R473Q	DNAH6_ENST00000237449.6_Missense_Mutation_p.R473Q|DNAH6_ENST00000398278.2_Missense_Mutation_p.R473Q	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	473	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						AAGCTAAAACGAACACCTTCA	0.348000													15	40					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16907974	16907974	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16907974A>T	ENST00000430580.2	-	15	2207	c.1320T>A	c.(1318-1320)gaT>gaA	p.D440E		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	440	NBPF 2.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CTTCATCCTCATCTTCGTCAT	0.433000													36	966					0	0	1	0	0
NRIP2	83714	broad.mit.edu	37	12	2936434	2936434	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2936434C>T	ENST00000337508.4	-	6	825	c.785G>A	c.(784-786)cGg>cAg	p.R262Q	ITFG2_ENST00000542548.1_Intron	NM_031474.2	NP_113662.1	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	262					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GGCTTTCAGCCGCAGCACTCC	0.622000													12	24					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3677394	3677394	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3677394C>T	ENST00000344754.4	-	10	2521	c.2522G>A	c.(2521-2523)gGt>gAt	p.G841D	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.G841D	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	841	Ig-like C2-type 8.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GACCTGGGGACCCAGGCTGGT	0.637000													13	64					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157509152	157509152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157509152G>A	ENST00000361835.3	-	7	1283	c.1126C>T	c.(1126-1128)Ccc>Tcc	p.P376S	FCRL5_ENST00000356953.4_Missense_Mutation_p.P376S|FCRL5_ENST00000368190.3_Missense_Mutation_p.P376S|FCRL5_ENST00000368189.3_Missense_Mutation_p.P376S|FCRL5_ENST00000368191.3_Missense_Mutation_p.P291S	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	376						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TGAGACACGGGAACTGAGAGA	0.458000													13	43					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43936053	43936053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43936053G>A	ENST00000262726.7	-	28	4086	c.3833C>T	c.(3832-3834)cCc>cTc	p.P1278L	EFCAB6_ENST00000396231.2_Missense_Mutation_p.P1126L|EFCAB6_ENST00000461800.1_5'UTR	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CTCCTGAGTGGGCAATGAGAG	0.612000													6	72					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480454	73480454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73480454G>A	ENST00000523207.1	+	2	1073	c.485G>A	c.(484-486)cGa>cAa	p.R162Q		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	162				ER -> DG (in Ref. 1; AAP46292).	regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding	p.R162Q(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			ATGCGAGAGCGAGAAGGAGAA	0.458000													9	169					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767669	57767669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57767669C>T	ENST00000371030.2	+	1	1595	c.1595C>T	c.(1594-1596)cCt>cTt	p.P532L		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	532						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					ACGCAGAAGCCTCTGAGCCCC	0.721000													4	4					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121971092	121971092	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:121971092C>T	ENST00000265922.3	-	7	1511	c.1050G>A	c.(1048-1050)gaG>gaA	p.E350E	DBC1_ENST00000482797.1_5'UTR	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		350					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GTCTCTGTGCCTCCGTGGCAC	0.577000													17	48					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111143688	111143688	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111143688G>A	ENST00000360467.5	+	37	3760		c.e37+1			NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2						angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGACAAACAGGTAAAATCTCC	0.542000													3	4					0	0	1	0	0
YTHDF1	54915	broad.mit.edu	37	20	61834443	61834443	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61834443G>A	ENST00000370339.3	-	4	1190	c.849C>T	c.(847-849)gcC>gcT	p.A283A	YTHDF1_ENST00000370333.4_Silent_p.A233A|YTHDF1_ENST00000370334.4_Intron	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	283	Gln/Pro-rich.			AP -> PH (in Ref. 5; CAD39029).						NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						GGGGGACTGGGGCCTTCGGCA	0.652000													36	100					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54147437	54147437	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:54147437C>T	ENST00000265572.3	-	3	789	c.492G>A	c.(490-492)gtG>gtA	p.V164V	OPRK1_ENST00000520287.1_Silent_p.V164V|OPRK1_ENST00000524278.1_Silent_p.V75V|RP11-162D9.3_ENST00000524425.1_RNA	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	164					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CCAAAGCCTTCACGGGGTGGC	0.488000													14	68					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67161070	67161070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:67161070C>T	ENST00000435165.2	+	1	694	c.39C>T	c.(37-39)ctC>ctT	p.L13L	SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371036.3_Intron|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000237247.6_Intron|SGIP1_ENST00000371037.4_Intron			Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	509					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CCTTCTCTCTCCCTTTCCTTA	0.468000													6	60					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20576124	20576124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20576124C>T	ENST00000329697.6	-	2	212	c.44G>A	c.(43-45)gGt>gAt	p.G15D	ACSM2B_ENST00000414188.2_Missense_Mutation_p.G15D|ACSM2B_ENST00000565232.1_Missense_Mutation_p.G15D|ACSM2B_ENST00000565322.1_Intron|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G15D	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	15					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						CATCTGAGTACCCCACAGGGT	0.493000													16	55					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69002342	69002342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69002342C>T	ENST00000409220.1	+	1	410	c.30C>T	c.(28-30)ttC>ttT	p.F10F	ARHGAP25_ENST00000409202.3_Intron|ARHGAP25_ENST00000497079.1_Silent_p.F10F|ARHGAP25_ENST00000456116.2_Intron|ARHGAP25_ENST00000467265.1_Intron|ARHGAP25_ENST00000295381.3_Intron|ARHGAP25_ENST00000409030.3_Silent_p.F10F|ARHGAP25_ENST00000544262.1_Intron	NM_001166276.1	NP_001159748.1	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	0					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CCTGTCTGTTCCTCTCTATAG	0.622000													115	277					0	0	1	0	0
DIS3	22894	broad.mit.edu	37	13	73346025	73346025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:73346025G>A	ENST00000377767.4	-	11	1613	c.1513C>T	c.(1513-1515)Cat>Tat	p.H505Y	DIS3_ENST00000377780.4_Missense_Mutation_p.H475Y|DIS3_ENST00000545453.1_Missense_Mutation_p.H343Y	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	505					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TCAGCAATATGAACACCAACC	0.333000										Multiple Myeloma(4;0.011)			22	104					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072297	134072297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:134072297C>T	ENST00000264360.4	+	1	1828	c.1002C>T	c.(1000-1002)ggC>ggT	p.G334G		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	334	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		AGGACCTGGGCCCCAACGCCG	0.597000													20	121					0	0	1	0	0
TEX11	56159	broad.mit.edu	37	X	70026601	70026601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70026601C>T	ENST00000395889.2	-	10	846	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K	TEX11_ENST00000374333.2_Missense_Mutation_p.E216K|TEX11_ENST00000344304.3_Missense_Mutation_p.E231K	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	231							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					TTCTGGGTTTCTACTCCAAAG	0.318000													10	4					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102956585	102956585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102956585G>A	ENST00000311734.2	+	4	639	c.300G>A	c.(298-300)gcG>gcA	p.A100A	IL1RL1_ENST00000393393.3_Silent_p.A100A|IL1RL1_ENST00000404917.2_5'UTR|IL1RL1_ENST00000233954.1_Silent_p.A100A|IL1RL1_ENST00000473175.1_3'UTR|IL1RL1_ENST00000409584.1_Silent_p.A100A			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	100	Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						CTGGATATGCGAATGTCACCA	0.299000													7	30					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228509866	228509866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228509866C>T	ENST00000570156.2	+	66	18269	c.18195C>T	c.(18193-18195)gcC>gcT	p.A6065A	OBSCN_ENST00000366707.4_Silent_p.A2742A|OBSCN_ENST00000422127.1_Silent_p.A5108A|OBSCN_ENST00000284548.11_Silent_p.A5108A|OBSCN_ENST00000366709.4_Silent_p.A2227A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5108	Ig-like 52.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGACTCCTGCCCCTGTGGTGC	0.602000													10	19					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72129198	72129198	+	Splice_Site	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:72129198A>T	ENST00000340726.3	-	13	1839		c.e13+1		EYA1_ENST00000303824.7_Splice_Site|EYA1_ENST00000388742.4_Splice_Site|EYA1_ENST00000388741.2_Splice_Site|EYA1_ENST00000388743.2_Splice_Site|EYA1_ENST00000388740.3_Splice_Site|EYA1_ENST00000419131.1_Splice_Site	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)						double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AAGGGTGCTCACCTTAGGTCC	0.358000													32	80					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6483972	6483972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6483972C>T	ENST00000263125.5	-	16	1818	c.1719G>A	c.(1717-1719)ctG>ctA	p.L573L	PRKCQ_ENST00000397176.2_Intron|PRKCQ_ENST00000539722.1_Silent_p.L448L	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	573	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						ACTGACCAATCAGCATTTCAT	0.517000													29	67					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58966695	58966695	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58966695C>T	ENST00000391696.1	+	3	1286	c.354C>T	c.(352-354)gcC>gcT	p.A118A	ZNF324B_ENST00000336614.4_Silent_p.A128A|ZNF324B_ENST00000545523.1_Silent_p.A128A			Q6AW86	Z324B_HUMAN	zinc finger protein 324B	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AACCGGGTGCCTCCCCATCTC	0.607000													35	87					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81065942	81065942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81065942C>T	ENST00000334512.5	+	22	3081	c.2509C>T	c.(2509-2511)Cct>Tct	p.P837S		NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	837					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CAAGGACGACCCTGATGGCAT	0.612000													18	41					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43708292	43708292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43708292G>A	ENST00000405312.3	-	2	413	c.176C>T	c.(175-177)cCc>cTc	p.P59L	PSG4_ENST00000433626.2_Missense_Mutation_p.P59L|PSG4_ENST00000244295.9_Missense_Mutation_p.P59L	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	59	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				AAGATTCTGGGGCAAATTGTG	0.443000													30	347					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152818521	152818521	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:152818521G>A	ENST00000370186.1	+	11	2136	c.1810G>A	c.(1810-1812)Gaa>Aaa	p.E604K	ATP2B3_ENST00000359149.3_Missense_Mutation_p.E618K|ATP2B3_ENST00000370181.2_Missense_Mutation_p.E604K|ATP2B3_ENST00000349466.2_Missense_Mutation_p.E618K|ATP2B3_ENST00000263519.4_Missense_Mutation_p.E618K|ATP2B3_ENST00000393842.1_Missense_Mutation_p.E604K			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	618					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCAATGGCGAACTCCGGGG	0.612000													23	13					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059682	152059682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152059682G>A	ENST00000368806.1	-	3	540	c.476C>T	c.(475-477)cCa>cTa	p.P159L		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	159							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTCTCTCCATGGGTCCACTCT	0.453000													16	100					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89537460	89537460	+	Missense_Mutation	SNP	C	C	T	rs141552770		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:89537460C>T	ENST00000329758.1	-	3	506	c.178G>A	c.(178-180)Gag>Aag	p.E60K	TRIM49_ENST00000532501.2_Missense_Mutation_p.E60K	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	60						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTTATCTGCTCGGTTGACTTT	0.463000													25	97					0	0	1	0	0
PLD4	122618	broad.mit.edu	37	14	105398476	105398476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105398476G>A	ENST00000540372.1	+	9	1399	c.1207G>A	c.(1207-1209)Gcg>Acg	p.A403T	PLD4_ENST00000392593.4_Missense_Mutation_p.A396T			Q96BZ4	PLD4_HUMAN	phospholipase D family, member 4	396					lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	13		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	GTCCCTGCAGGCGCTCAGCAA	0.731000													7	22					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70924606	70924606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70924606G>A	ENST00000603540.1	+	2	648	c.390G>A	c.(388-390)ggG>ggA	p.G130G	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Silent_p.G130G	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	130					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CTTGTTTTGGGGGCTTTCGAG	0.453000													39	109					0	0	1	0	0
ZNF512B	57473	broad.mit.edu	37	20	62598022	62598022	+	Missense_Mutation	SNP	G	G	A	rs140764494	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62598022G>A	ENST00000450537.1	-	5	566	c.506C>T	c.(505-507)cCt>cTt	p.P169L	ZNF512B_ENST00000217130.3_Missense_Mutation_p.P169L|ZNF512B_ENST00000369888.1_Missense_Mutation_p.P169L			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CTTGGAGGCAGGCAGGGGTCG	0.622000													22	79					0	0	1	0	0
TMEM156	80008	broad.mit.edu	37	4	39000451	39000451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39000451G>A	ENST00000381938.3	-	2	274	c.167C>T	c.(166-168)tCt>tTt	p.S56F	TMEM156_ENST00000372489.2_5'UTR	NM_024943.1	NP_079219.1	Q8N614	TM156_HUMAN	transmembrane protein 156	56						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						AGTCACAAAAGAAAAATTTAA	0.353000													17	32					0	0	1	0	0
TUBA4A	7277	broad.mit.edu	37	2	220116411	220116411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220116411C>T	ENST00000392088.2	-	3	761	c.206G>A	c.(205-207)cGa>cAa	p.R69Q	TUBA4A_ENST00000498660.1_5'UTR|TUBA4A_ENST00000248437.4_Missense_Mutation_p.R84Q	NM_001278552.1	NP_001265481.1	P68366	TBA4A_HUMAN	tubulin, alpha 4a	84					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAAGAGCTGTCGGTATGGGCC	0.542000													27	39					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603793	5603793	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5603793G>A	ENST00000423158.3	+	2	664	c.452G>A	c.(451-453)cGg>cAg	p.R151Q	NTF3_ENST00000331010.6_Missense_Mutation_p.R138Q|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	138					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding	p.R138Q(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						CGGCGGAAACGGTACGCGGAG	0.602000													33	66					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100190865	100190865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:100190865C>T	ENST00000355295.4	+	2	413	c.118C>T	c.(118-120)Ccc>Tcc	p.P40S	TDRD7_ENST00000422139.2_Intron	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	40	Lotus/OST-HTH 1.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				AGACTGGATCCCCTTCAAACA	0.483000													17	61					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631951	32631951	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32631951G>A	ENST00000242310.4	-	1	3716	c.3627C>T	c.(3625-3627)gtC>gtT	p.V1209V		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1209					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGGCATCAATGACAGCTGGTT	0.428000													61	96					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27419836	27419836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:27419836G>A	ENST00000211936.6	-	6	1786	c.1502C>T	c.(1501-1503)cCc>cTc	p.P501L	ZNF184_ENST00000377419.1_Missense_Mutation_p.P501L	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						GCATTCAAAGGGCTTTTCTCT	0.388000													19	81					0	0	1	0	0
ZNF358	140467	broad.mit.edu	37	19	7584262	7584262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7584262C>T	ENST00000597229.1	+	2	304	c.134C>T	c.(133-135)cCt>cTt	p.P45L	CTD-2207O23.12_ENST00000599312.1_3'UTR|ZNF358_ENST00000394341.2_Missense_Mutation_p.P45L	NM_018083.4	NP_060553.4	Q9NW07	ZN358_HUMAN	zinc finger protein 358	45					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|lung(1)|skin(2)	8						GACCCAGAGCCTGATCCTGAA	0.582000													36	73					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114541218	114541218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:114541218G>A	ENST00000371920.3	+	4	798	c.791G>A	c.(790-792)aGa>aAa	p.R264K	LUZP4_ENST00000451986.2_Missense_Mutation_p.R182K	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	264						nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						GCCACTCAGAGAGATCTCATA	0.478000													43	35					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43897964	43897964	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43897964C>T	ENST00000562955.1	+	36	5125	c.5125C>T	c.(5125-5127)Cct>Tct	p.P1709S	SZT2_ENST00000372442.1_Missense_Mutation_p.P867S	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1766						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CCTCCATCTCCCTGGCCATGT	0.577000													113	303					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41615664	41615664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41615664G>A	ENST00000313860.7	+	7	722	c.668G>A	c.(667-669)aGg>aAg	p.R223K	LIMCH1_ENST00000509638.1_Missense_Mutation_p.R64K|LIMCH1_ENST00000381753.4_Missense_Mutation_p.R69K|LIMCH1_ENST00000513024.1_Missense_Mutation_p.R64K|LIMCH1_ENST00000508501.1_Missense_Mutation_p.R223K|LIMCH1_ENST00000509454.1_Missense_Mutation_p.R71K|LIMCH1_ENST00000512946.1_Missense_Mutation_p.R223K|LIMCH1_ENST00000509277.1_Missense_Mutation_p.R69K|LIMCH1_ENST00000511496.1_Missense_Mutation_p.R64K|LIMCH1_ENST00000512820.1_Missense_Mutation_p.R223K|LIMCH1_ENST00000503057.1_Missense_Mutation_p.R64K|LIMCH1_ENST00000512632.1_Missense_Mutation_p.R223K|LIMCH1_ENST00000514096.1_Missense_Mutation_p.R76K|LIMCH1_ENST00000396595.3_Missense_Mutation_p.R69K	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	223					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						GTAGTCCTCAGGGGAAGCAGC	0.542000													9	64					0	0	1	0	0
ZNF662	389114	broad.mit.edu	37	3	42956099	42956099	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42956099C>T	ENST00000541208.1	+	5	903	c.534C>T	c.(532-534)ctC>ctT	p.L178L	ZNF662_ENST00000328199.6_Silent_p.L204L|ZNF662_ENST00000422021.1_Intron|KRBOX1_ENST00000426937.1_Intron|ZNF662_ENST00000440367.2_Silent_p.L178L			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		TCAATAACCTCCTTGGTATAC	0.353000													29	71					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228486318	228486318	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228486318G>A	ENST00000570156.2	+	49	13184	c.13110G>A	c.(13108-13110)acG>acA	p.T4370T	OBSCN_ENST00000366707.4_Silent_p.T1060T|RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000359599.6_3'UTR|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366709.4_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3413	Ig-like 45.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGATGGGACGAGGTGTGAGC	0.587000													32	75					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8181592	8181592	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8181592G>A	ENST00000600128.1	-	29	4092	c.3678C>T	c.(3676-3678)ggC>ggT	p.G1226G	FBN3_ENST00000601739.1_Silent_p.G1226G|FBN3_ENST00000270509.2_Silent_p.G1226G			Q75N90	FBN3_HUMAN	fibrillin 3	1226	EGF-like 17.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGGCCATGAAGCCATCATAGC	0.627000													14	109					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736825	140736825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140736825C>T	ENST00000571252.1	+	1	2058	c.2058C>T	c.(2056-2058)gaC>gaT	p.D686D	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCCAGACGACTCGGGCCTCA	0.617000													26	49					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940459	144940459	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144940459G>A	ENST00000525985.1	-	2	7034	c.6963C>T	c.(6961-6963)ctC>ctT	p.L2321L				P58107	EPIPL_HUMAN	epiplakin 1	2321						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGCCTGGAAGAGGGAGATCT	0.706000													17	335					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89914988	89914988	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89914988C>T	ENST00000405460.2	+	4	539	c.443C>T	c.(442-444)tCa>tTa	p.S148L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	148					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGAATTATTTCATTTAATATG	0.289000													5	10					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7561562	7561562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:7561562C>T	ENST00000399429.3	-	5	873	c.733G>A	c.(733-735)Gga>Aga	p.G245R		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	245	Collagen-like 1.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CCTGGATCTCCCTTCTCACAT	0.378000													18	58					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48652918	48652918	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48652918C>T	ENST00000352832.5	+	8	1527	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	CACNA1G_ENST00000512389.1_Silent_p.F385F|CACNA1G_ENST00000507336.1_Silent_p.F385F|CACNA1G_ENST00000507609.1_Silent_p.F385F|CACNA1G_ENST00000354983.4_Silent_p.F385F|CACNA1G_ENST00000503485.1_Silent_p.F385F|CACNA1G_ENST00000507896.1_Silent_p.F385F|CACNA1G_ENST00000358244.5_Silent_p.F385F|CACNA1G_ENST00000510115.1_Silent_p.F385F|CACNA1G_ENST00000510366.1_Silent_p.F385F|CACNA1G_ENST00000502264.1_Silent_p.F385F|CACNA1G_ENST00000429973.2_Silent_p.F385F|CACNA1G_ENST00000416767.4_Silent_p.F385F|CACNA1G_ENST00000360761.4_Silent_p.F385F|CACNA1G_ENST00000515765.1_Silent_p.F385F|CACNA1G_ENST00000515411.1_Silent_p.F385F|CACNA1G_ENST00000442258.2_Silent_p.F385F|CACNA1G_ENST00000515165.1_Silent_p.F385F|CACNA1G_ENST00000505165.1_Silent_p.F385F|CACNA1G_ENST00000359106.5_Silent_p.F385F|CACNA1G_ENST00000514717.1_Silent_p.F385F|CACNA1G_ENST00000514181.1_Silent_p.F385F|CACNA1G_ENST00000514079.1_Silent_p.F385F|CACNA1G_ENST00000513964.1_Silent_p.F385F|CACNA1G_ENST00000507510.2_Silent_p.F385F|CACNA1G_ENST00000513689.2_Silent_p.F385F	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	385					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCTCCTTCTTCATGATCAACC	0.552000													13	26					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100402849	100402849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100402849C>T	ENST00000358173.3	-	16	3241	c.2773G>A	c.(2773-2775)Gaa>Aaa	p.E925K	EPHB4_ENST00000360620.3_Intron	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	925	SAM.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					AAACTTTCTTCGTATCTTCCC	0.602000													4	16					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39564382	39564382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39564382C>T	ENST00000265707.5	+	18	2021	c.1976C>T	c.(1975-1977)tCc>tTc	p.S659F	ADAM18_ENST00000541111.1_Missense_Mutation_p.S73F|ADAM18_ENST00000379866.1_Missense_Mutation_p.S635F|ADAM18_ENST00000523755.1_3'UTR	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	659					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CAGTTTGGTTCCCCAGGGGGT	0.318000													10	64					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123846092	123846092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123846092G>A	ENST00000369005.1	+	4	4417	c.4077G>A	c.(4075-4077)ggG>ggA	p.G1359G	TACC2_ENST00000334433.3_Silent_p.G1359G|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Silent_p.G1359G|TACC2_ENST00000515273.1_Silent_p.G1359G|TACC2_ENST00000453444.2_Silent_p.G1359G	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1359						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGGCCAGTGGGGAGGGCATGG	0.622000													18	35					0	0	1	0	0
CSF3R	1441	broad.mit.edu	37	1	36939451	36939451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36939451C>T	ENST00000373103.1	-	5	946	c.399G>A	c.(397-399)atG>atA	p.M133I	CSF3R_ENST00000440588.2_Missense_Mutation_p.M133I|CSF3R_ENST00000331941.5_Missense_Mutation_p.M133I|CSF3R_ENST00000373106.1_Missense_Mutation_p.M133I|CSF3R_ENST00000361632.4_Missense_Mutation_p.M133I|CSF3R_ENST00000373104.1_Missense_Mutation_p.M133I|CSF3R_ENST00000418048.2_Missense_Mutation_p.M133I|CSF3R_ENST00000338937.5_Missense_Mutation_p.M133I	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	133	Fibronectin type-III 1.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTGTGAGGTTCATGAGGCAGG	0.592000													22	58					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27343200	27343200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:27343200G>A	ENST00000429845.2	-	14	1517	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	NEK10_ENST00000341435.5_Silent_p.F385F			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	385							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CTTGAAGTGAGAAAGTATTTT	0.353000													3	11					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47860722	47860722	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47860722G>A	ENST00000289672.2	-	46	6967	c.6917C>T	c.(6916-6918)tCc>tTc	p.S2306F		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2306					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TTCATCTTGGGAAAATCTCCC	0.413000													17	45					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158724951	158724951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158724951G>A	ENST00000368144.2	+	1	442	c.346G>A	c.(346-348)Gag>Aag	p.E116K		NM_001005184.1	NP_001005184.1	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K, member 6	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(17)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0378)					CCTAATCAGTGAGCAGAAGAG	0.498000													51	121					0	0	1	0	0
MIIP	60672	broad.mit.edu	37	1	12090106	12090106	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12090106C>T	ENST00000235332.4	+	8	1036	c.867C>T	c.(865-867)atC>atT	p.I289I	MIIP_ENST00000436478.2_Intron|MIIP_ENST00000466860.1_3'UTR	NM_021933.3	NP_068752.2	Q5JXC2	MIIP_HUMAN	migration and invasion inhibitory protein	289										autonomic_ganglia(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						CGCTGTCGATCCTGGAGCCCC	0.682000													18	52					0	0	1	0	0
KIT	3815	broad.mit.edu	37	4	55564480	55564480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55564480C>T	ENST00000288135.5	+	3	465	c.368C>T	c.(367-369)tCc>tTc	p.S123F		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	123	Ig-like C2-type 2.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.S123F(1)		NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTTGACCGCTCCTTGTATGGG	0.473000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				10	19					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043645	71043645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71043645C>T	ENST00000272367.2	-	4	944	c.868G>A	c.(868-870)Gaa>Aaa	p.E290K	CLEC4F_ENST00000426626.1_Missense_Mutation_p.E290K	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	290					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TGCAAATTTTCCTTTAGTCCC	0.418000													55	157					0	0	1	0	0
CDA	978	broad.mit.edu	37	1	20915649	20915649	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20915649C>T	ENST00000375071.3	+	1	209	c.27C>T	c.(25-27)acC>acT	p.T9T	CDA_ENST00000461985.1_3'UTR	NM_001785.2	NP_001776.1	P32320	CDD_HUMAN	cytidine deaminase	9					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	7		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	CTGCCTGCACCCTGAAGCCTG	0.657000													13	74					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156916190	156916190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156916190G>A	ENST00000257527.4	-	20	2323	c.2245C>T	c.(2245-2247)Ccc>Tcc	p.P749S	ADAM19_ENST00000394020.1_Missense_Mutation_p.P751S|ADAM19_ENST00000430702.2_Missense_Mutation_p.P482S|ADAM19_ENST00000517905.1_Missense_Mutation_p.P749S	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	749					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACCCTGAAGGGACAACTAGAA	0.547000													8	23					0	0	1	0	0
PDLIM2	64236	broad.mit.edu	37	8	22442865	22442865	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22442865C>T	ENST00000265810.4	+	5	608	c.493C>T	c.(493-495)Ccc>Tcc	p.P165S	PDLIM2_ENST00000308354.7_Missense_Mutation_p.P415S|PDLIM2_ENST00000397760.4_Missense_Mutation_p.P165S|PDLIM2_ENST00000397761.2_Missense_Mutation_p.P165S|PDLIM2_ENST00000448520.1_3'UTR|PDLIM2_ENST00000409141.1_Missense_Mutation_p.P165S|PDLIM2_ENST00000339162.7_Missense_Mutation_p.P165S|PDLIM2_ENST00000409417.1_Missense_Mutation_p.P165S	NM_176871.3	NP_789847.1	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 (mystique)	165						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		CCCGGGCCTCCCCGCTGCTGA	0.677000													9	16					0	0	1	0	0
CLDN8	9073	broad.mit.edu	37	21	31588018	31588018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31588018C>T	ENST00000399899.1	-	1	373	c.226G>A	c.(226-228)Gac>Aac	p.D76N	CLDN8_ENST00000286809.1_Missense_Mutation_p.D76N	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	76					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						GCCTGTAGGTCCGGAGAAAGA	0.512000													33	72					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76732370	76732370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76732370C>T	ENST00000287239.4	+	7	1523	c.1034C>T	c.(1033-1035)cCg>cTg	p.P345L	KAT6B_ENST00000372714.1_Missense_Mutation_p.P345L|KAT6B_ENST00000372725.1_Missense_Mutation_p.P345L|KAT6B_ENST00000372724.1_Missense_Mutation_p.P345L|KAT6B_ENST00000372711.1_Missense_Mutation_p.P345L	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	345					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										ATTGGACGACCGAAAAATAAA	0.338000													53	158					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327598	85327598	+	Silent	SNP	C	C	T	rs148220929		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85327598C>T	ENST00000299927.3	+	1	1714	c.1692C>T	c.(1690-1692)ccC>ccT	p.P564P	ZNF592_ENST00000560079.2_Silent_p.P564P			Q92610	ZN592_HUMAN	zinc finger protein 592	564					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCTCCAACCCCGTGCCCCTCT	0.592000													53	184					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230902178	230902178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230902178C>T	ENST00000295190.4	-	5	1909	c.1451G>A	c.(1450-1452)gGa>gAa	p.G484E		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	484						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		AAAGAGTATTCCTATCATGTA	0.333000													18	49					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16205242	16205242	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16205242C>T	ENST00000399408.2	+	23	3087	c.2912C>T	c.(2911-2913)tCc>tTc	p.S971F	ABCC1_ENST00000351154.5_Missense_Mutation_p.S902F|ABCC1_ENST00000346370.5_Missense_Mutation_p.S905F|ABCC1_ENST00000349029.5_Missense_Mutation_p.S846F|ABCC1_ENST00000345148.5_Missense_Mutation_p.S961F|ABCC1_ENST00000399410.3_Missense_Mutation_p.S961F			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	961					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTCAAGCTTTCCGTGTACTGG	0.557000													55	142					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53220037	53220037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53220037C>T	ENST00000394729.2	+	11	1408	c.1080C>T	c.(1078-1080)ttC>ttT	p.F360F	PRKCD_ENST00000330452.3_Silent_p.F360F	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	360	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		AAGGCAGCTTCGGGAAGGTGA	0.607000													12	39					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898763	36898763	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36898763C>T	ENST00000301807.6	-	12	2565	c.668G>A	c.(667-669)tGg>tAg	p.W223*	TRANK1_ENST00000429976.2_Nonsense_Mutation_p.W773*|TRANK1_ENST00000428977.2_Nonsense_Mutation_p.W223*	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	773					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CTGCGTGCTCCAGTCATCCTG	0.542000													76	297					0	0	1	0	0
LINC01098	285501	broad.mit.edu	37	4	178897018	178897018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:178897018G>A	ENST00000507870.1	+	5	683	c.221G>A	c.(220-222)gGg>gAg	p.G74E																	lung(8)|prostate(1)	9						ACGGGAAAGGGGTTGAGCAAG	0.403000													41	102					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42719313	42719313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:42719313C>T	ENST00000230882.4	+	10	1894	c.1704C>T	c.(1702-1704)acC>acT	p.T568T	GHR_ENST00000357703.3_Silent_p.T546T|GHR_ENST00000537449.1_Silent_p.T381T	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	568					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTTACATCACCACAGAAAGCC	0.488000													9	32					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821046	43821046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43821046C>T	ENST00000417669.1	+	2	499	c.55C>T	c.(55-57)Ctc>Ttc	p.L19F	MPPED1_ENST00000443721.1_Missense_Mutation_p.L19F|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000542779.1_Missense_Mutation_p.L19F|MPPED1_ENST00000538182.1_Missense_Mutation_p.L52F			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	19							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				CCTGGCCCTCCTCCCCTGCGG	0.711000													5	27					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129853969	129853969	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:129853969C>T	ENST00000373425.3	-	4	1879	c.1262G>A	c.(1261-1263)aGa>aAa	p.R421K	RALGPS1_ENST00000373434.1_Intron|RALGPS1_ENST00000259351.5_Intron|RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000373436.1_Intron|ANGPTL2_ENST00000373417.1_Missense_Mutation_p.R119K|RALGPS1_ENST00000424082.2_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	421	Fibrinogen C-terminal.				multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						ATCATGATCTCTGTCCAGGGT	0.552000													75	239					0	0	1	0	0
SRP72	6731	broad.mit.edu	37	4	57350913	57350913	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:57350913C>T	ENST00000342756.5	+	10	1690	c.969C>T	c.(967-969)tgC>tgT	p.C323C	SRP72_ENST00000510663.1_Silent_p.C262C	NM_006947.3	NP_008878.3	O76094	SRP72_HUMAN	signal recognition particle 72kDa	323					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					CTGAACAATGCCGCAAAATAT	0.413000													33	144					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57372430	57372430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57372430G>A	ENST00000361249.3	+	8	1283	c.1187G>A	c.(1186-1188)gGa>gAa	p.G396E		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	396	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGTTTATCAGGAGACCATTGT	0.423000													53	127					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7770734	7770734	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:7770734G>A	ENST00000420658.1	-	17	2527	c.2253_splice	c.e17-1	p.S752_splice	AFAP1_ENST00000513842.1_5'UTR|AFAP1_ENST00000382543.3_Splice_Site_p.S752_splice|AFAP1_ENST00000358461.2_Splice_Site_p.S668_splice|AFAP1_ENST00000360265.4_Splice_Site_p.S668_splice	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	668						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						GAACACTGGAGACTTAACGGA	0.547000													36	121					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155156512	155156512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155156512C>T	ENST00000357232.3	-	25	7926	c.7927G>A	c.(7927-7929)Gaa>Aaa	p.E2643K		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2643					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GTTTCTCCTTCCACAGAACAG	0.468000													21	88					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97466366	97466366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97466366C>T	ENST00000389672.5	+	17	3266	c.3228C>T	c.(3226-3228)ttC>ttT	p.F1076F		NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	981						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AGAATAACTTCGTGGCAGCAG	0.423000													12	16					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112144721	112144721	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112144721C>T	ENST00000412145.1	-	19	4549	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K	PTPN3_ENST00000374541.2_Missense_Mutation_p.E797K|PTPN3_ENST00000394827.3_Missense_Mutation_p.E265K|PTPN3_ENST00000262539.3_Missense_Mutation_p.E643K|PTPN3_ENST00000446349.1_Missense_Mutation_p.E621K	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	797	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GTGTGTTCTTCCCCGGTCTGT	0.577000													30	23					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119729101	119729101	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:119729101G>A	ENST00000541757.1	+	5	597	c.217G>A	c.(217-219)Ggc>Agc	p.G73S	MARCO_ENST00000327097.4_Missense_Mutation_p.G151S			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	151					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGGTGAACAAGGCGCCCCAGG	0.582000													39	88					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38793802	38793802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38793802G>A	ENST00000449082.2	-	11	1662	c.1663C>T	c.(1663-1665)Cct>Tct	p.P555S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	555					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTGGGTTGAGGAAGAGGGCTT	0.602000													30	76					0	0	1	0	0
TMEM30A	55754	broad.mit.edu	37	6	75994289	75994289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:75994289G>A	ENST00000230461.6	-	1	395	c.66C>T	c.(64-66)acC>acT	p.T22T	TMEM30A_ENST00000475111.2_Silent_p.T22T	NM_018247.3	NP_060717.1	Q9NV96	CC50A_HUMAN	transmembrane protein 30A	22						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(8)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GAGTCTTCGCGGTGCCCCCCG	0.617000													21	139					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515442	140515442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140515442C>T	ENST00000231134.5	+	1	643	c.426C>T	c.(424-426)atC>atT	p.I142I		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		142	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTAAAAATCCCAGAGAGCA	0.438000													20	87					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40312406	40312406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:40312406C>T	ENST00000264661.3	-	16	3038	c.2706G>A	c.(2704-2706)cgG>cgA	p.R902R	KCNH4_ENST00000607371.1_Silent_p.R902R	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	902					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCATGATGTGCCGCAGCTCCC	0.592000													16	34					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37388776	37388776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37388776C>T	ENST00000361924.2	+	21	6939	c.6565C>T	c.(6565-6567)Cgt>Tgt	p.R2189C	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.R2204C	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	2189	GRIP.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TATGATGGGTCGTGAGACTAA	0.368000													11	96					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21348460	21348460	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21348460C>T	ENST00000215739.8	+	14	1876	c.1517C>T	c.(1516-1518)cCg>cTg	p.P506L	LZTR1_ENST00000389355.3_Missense_Mutation_p.P487L|LZTR1_ENST00000479606.1_3'UTR	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	506	BTB 1.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GGGGCCCGGCCGCCCCTGCTG	0.682000													6	14					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96522620	96522620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96522620C>T	ENST00000371321.3	+	1	240	c.158C>T	c.(157-159)tCc>tTc	p.S53F	CYP2C19_ENST00000464755.1_Intron	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	53					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GTCAGCAAATCCTTAACCAAT	0.403000													30	66					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149903251	149903251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149903251G>A	ENST00000439741.2	-	13	1441	c.1191C>T	c.(1189-1191)gcC>gcT	p.A397A	MTMR11_ENST00000406732.3_Intron|MTMR11_ENST00000492824.1_Intron|MTMR11_ENST00000361405.6_Intron|MTMR11_ENST00000369140.3_Silent_p.A325A	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	397	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACAGTGTTCGGGCTTCGGGGG	0.567000													12	79					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37680644	37680644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37680644G>A	ENST00000532828.2	-	4	462	c.211C>T	c.(211-213)Cct>Tct	p.P71S	ZNF585B_ENST00000527838.1_Missense_Mutation_p.P71S|CTC-454I21.3_ENST00000585860.2_Missense_Mutation_p.P71S|ZNF585B_ENST00000586320.1_Missense_Mutation_p.P56S|ZNF585B_ENST00000531805.1_Missense_Mutation_p.P16S	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTGGTTTAGGAACTTGATAC	0.478000													28	63					0	0	1	0	0
S1PR3	1903	broad.mit.edu	37	9	91616823	91616823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91616823G>A	ENST00000375846.3	+	1	5403	c.708G>A	c.(706-708)gaG>gaA	p.E236E	S1PR3_ENST00000358157.2_Silent_p.E236E			Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	236					anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(1)	34						ACAACTCGGAGCGGTCCATGG	0.577000													14	51					0	0	1	0	0
SLC2A12	154091	broad.mit.edu	37	6	134349893	134349893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:134349893G>A	ENST00000275230.5	-	2	1225	c.1070C>T	c.(1069-1071)tCg>tTg	p.S357L		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	357						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		GGTCACCAACGAAGCTGCCAT	0.493000													23	50					0	0	1	0	0
OR5M10	390167	broad.mit.edu	37	11	56344463	56344463	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56344463C>T	ENST00000526812.2	-	1	800	c.735G>A	c.(733-735)ctG>ctA	p.L245L		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						TGACTATTGTCAGGTGGGAAG	0.428000													13	137					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43614358	43614358	+	Silent	SNP	G	G	A	rs142184960		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43614358G>A	ENST00000360835.3	-	15	1920	c.1794C>T	c.(1792-1794)gtC>gtT	p.V598V		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	598					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				CAGTGCCTGAGACCTGGACAT	0.647000													75	102					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42227377	42227377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42227377G>A	ENST00000541110.1	-	9	2597	c.2029C>T	c.(2029-2031)Cgg>Tgg	p.R677W	TRERF1_ENST00000354325.2_Missense_Mutation_p.R574W|TRERF1_ENST00000340840.2_Missense_Mutation_p.R574W|TRERF1_ENST00000372917.4_Missense_Mutation_p.R574W|TRERF1_ENST00000372922.4_Missense_Mutation_p.R657W			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	657	Interacts with CREBBP.|Pro-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGTTCCGGCCGGTGCCGGAAC	0.637000													12	87					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43492321	43492321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43492321G>A	ENST00000282041.5	-	22	3951	c.3917C>T	c.(3916-3918)cCc>cTc	p.P1306L	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1306					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TGGCAGGAGGGGGTGATCAGA	0.557000													10	75					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156816441	156816441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156816441C>T	ENST00000368195.3	-	8	2076	c.1680G>A	c.(1678-1680)gtG>gtA	p.V560V	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	560	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGGCTAGGGTCACCCCTGGCT	0.612000													8	62					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38516844	38516844	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38516844C>T	ENST00000399017.2	+	21	4539	c.1792C>T	c.(1792-1794)Cac>Tac	p.H598Y	TTC3_ENST00000540756.1_Missense_Mutation_p.H288Y|TTC3_ENST00000355666.1_Missense_Mutation_p.H598Y|TTC3_ENST00000354749.2_Missense_Mutation_p.H598Y|TTC3_ENST00000479930.1_3'UTR	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	598					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				AGCTCTCAATCACTTTGAGAA	0.348000													11	143					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371732	240371732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240371732C>T	ENST00000319653.9	+	5	3850	c.3620C>T	c.(3619-3621)cCc>cTc	p.P1207L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1207	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCTGGGATTCCCCCACCTCCT	0.657000													18	26					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45309885	45309885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45309885G>A	ENST00000313237.5	-	5	798	c.648C>T	c.(646-648)ccC>ccT	p.P216P	PHF21B_ENST00000404079.2_Intron|PHF21B_ENST00000396103.3_Intron|PHF21B_ENST00000403565.1_Intron|PHF21B_ENST00000447824.3_Intron	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	216							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		gtgatggggagggaggggtga	0.642000													20	40					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	818660	818660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:818660G>A	ENST00000566549.1	+	17	2213	c.1796G>A	c.(1795-1797)gGg>gAg	p.G599E	MSLN_ENST00000545450.2_Missense_Mutation_p.G599E|MSLN_ENST00000382862.3_Missense_Mutation_p.G607E|MSLN_ENST00000563941.1_Missense_Mutation_p.G599E			Q13421	MSLN_HUMAN	mesothelin	607					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				GCCCTCTCGGGGACGCCCTGC	0.711000													10	50					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73044544	73044544	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73044544G>A	ENST00000335350.6	+	3	788	c.372G>A	c.(370-372)gaG>gaA	p.E124E	UNC5B_ENST00000373192.4_Silent_p.E124E	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	124	Ig-like.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						TTGGGCTGGAGGATTACTGGT	0.682000													37	72					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125288811	125288811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125288811G>A	ENST00000304880.2	-	1	761	c.762C>T	c.(760-762)ttC>ttT	p.F254F		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	254					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F254F(1)		breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						GGTAGGCACTGAAGAGGGTCC	0.542000													25	40					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124380660	124380660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124380660G>A	ENST00000368909.3	+	41	5091	c.4985G>A	c.(4984-4986)gGa>gAa	p.G1662E	DMBT1_ENST00000330163.4_Missense_Mutation_p.G1034E|DMBT1_ENST00000368955.3_Missense_Mutation_p.G1652E|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Missense_Mutation_p.G1034E|DMBT1_ENST00000344338.3_Missense_Mutation_p.G1652E|DMBT1_ENST00000338354.3_Missense_Mutation_p.G1662E	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1662	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGCTCCTGGGGAACCGTGTGT	0.592000													117	324					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58954710	58954710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:58954710C>T	ENST00000423743.3	+	24	3536	c.3278C>T	c.(3277-3279)tCc>tTc	p.S1093F	KIAA0586_ENST00000261244.5_Missense_Mutation_p.S1061F|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000354386.6_Missense_Mutation_p.S1190F|KIAA0586_ENST00000556134.1_Missense_Mutation_p.S1122F	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	1061										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCAGATATTTCCATTGATAAA	0.473000													11	19					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071765	9071765	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9071765G>A	ENST00000397910.4	-	3	15884	c.15681C>T	c.(15679-15681)gtC>gtT	p.V5227V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5229	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGAAGAGTTGACCCCTGTAC	0.498000													19	128					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409091	105409091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105409091C>T	ENST00000333244.5	-	7	12816	c.12697G>A	c.(12697-12699)Ggc>Agc	p.G4233S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4233						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACCTGGGGGCCCTTGAGGGCC	0.647000													84	235					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038703	75038703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75038703C>T	ENST00000326665.5	-	14	2909	c.2691G>A	c.(2689-2691)caG>caA	p.Q897Q	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	897	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCTCTAAACCCTGTTCCCCTT	0.512000													85	265					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513626	78513626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:78513626C>T	ENST00000397909.2	+	15	3823	c.3650C>T	c.(3649-3651)tCc>tTc	p.S1217F	NAV3_ENST00000266692.7_Missense_Mutation_p.S1217F|NAV3_ENST00000536525.2_Missense_Mutation_p.S1217F|NAV3_ENST00000228327.6_Missense_Mutation_p.S1217F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1217	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTGTCAGGTTCCCCCAAATCC	0.522000										HNSCC(70;0.22)			25	82					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117292939	117292939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117292939C>T	ENST00000003084.6	+	24	4049	c.3917C>T	c.(3916-3918)cCc>cTc	p.P1306L	CFTR_ENST00000454343.1_Missense_Mutation_p.P1245L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1306	ABC transporter 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AACTTGGATCCCTATGAACAG	0.299000									Cystic Fibrosis				8	95					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6091073	6091073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6091073G>A	ENST00000217289.4	-	5	1406	c.618C>T	c.(616-618)ttC>ttT	p.F206F	FERMT1_ENST00000536936.1_Intron	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	206	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						GGCTGTCACTGAACCAAGTCA	0.522000													27	105					0	0	1	0	0
ARNTL2	56938	broad.mit.edu	37	12	27553473	27553473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:27553473G>A	ENST00000544915.1	+	9	1043	c.824G>A	c.(823-825)aGa>aAa	p.R275K	ARNTL2_ENST00000266503.5_Missense_Mutation_p.R309K|ARNTL2_ENST00000542388.1_Missense_Mutation_p.R224K|ARNTL2_ENST00000395901.2_Missense_Mutation_p.R272K|ARNTL2_ENST00000261178.5_Missense_Mutation_p.R261K|ARNTL2_ENST00000546179.1_Missense_Mutation_p.R272K|ARNTL2_ENST00000311001.5_Missense_Mutation_p.R295K|RP11-165P7.1_ENST00000500498.2_RNA	NM_020183.4	NP_064568.3	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear translocator-like 2	309					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	21	Colorectal(261;0.0847)|Lung SC(9;0.184)					TTAGAGCACAGAAAATTCTAT	0.294000													26	58					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57476429	57476429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57476429G>A	ENST00000371236.2	-	14	1870	c.1607C>T	c.(1606-1608)cCa>cTa	p.P536L	DAB1_ENST00000371231.1_Missense_Mutation_p.P569L|DAB1_ENST00000439789.2_Missense_Mutation_p.P450L|DAB1_ENST00000371234.4_Missense_Mutation_p.P536L|DAB1_ENST00000420954.2_Missense_Mutation_p.P534L|DAB1_ENST00000414851.2_Missense_Mutation_p.P518L|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	569					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CTCACCAAATGGATCACTGTT	0.438000													32	84					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111409813	111409813	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111409813G>A	ENST00000265162.5	+	2	1103	c.761G>A	c.(760-762)gGa>gAa	p.G254E		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	254					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AAAGAATACGGAGCACTTTCA	0.383000													62	36					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130833139	130833139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130833139G>A	ENST00000357462.5	-	15	1999	c.1906C>T	c.(1906-1908)Ctt>Ttt	p.L636F	POTEF_ENST00000360967.5_3'UTR|POTEF_ENST00000361163.4_3'UTR|POTEF_ENST00000409914.2_Missense_Mutation_p.L636F			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	636						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TTACAACTAAGAGAAAGCTAA	0.323000													7	30					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884112	39884112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39884112C>T	ENST00000341184.6	+	2	975	c.760C>T	c.(760-762)Cgg>Tgg	p.R254W		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	254					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GCTCAAGTTCCGGGAGATGCT	0.642000													27	72					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36641484	36641484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36641484G>A	ENST00000373448.2	-	3	973	c.735C>T	c.(733-735)ttC>ttT	p.F245F	TTI1_ENST00000373447.3_Silent_p.F245F|TTI1_ENST00000449821.1_Silent_p.F245F|TTI1_ENST00000487362.1_Intron	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	245							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						CAGCCATAATGAAGCTCACTG	0.433000													72	168					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964677	70964677	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70964677G>A	ENST00000357250.6	-	24	1812	c.1654C>T	c.(1654-1656)Cct>Tct	p.P552S	COL9A1_ENST00000370499.4_Missense_Mutation_p.P309S|COL9A1_ENST00000320755.7_Missense_Mutation_p.P309S|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	552	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						TTTGTTCCAGGCATTCCAGGG	0.468000													11	27					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71604216	71604216	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71604216G>A	ENST00000355962.4	-	9	1130	c.997C>T	c.(997-999)Cgc>Tgc	p.R333C	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	333					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CCCGGGGTGCGACATAGGATG	0.547000													22	52					0	0	1	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581261	234581261	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234581261C>T	ENST00000354728.4	+	1	763	c.681C>T	c.(679-681)gcC>gcT	p.A227A	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		TCAAAAATGCCCTAGAAATAG	0.423000													89	440					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152605214	152605214	+	Missense_Mutation	SNP	C	C	T	rs147615757		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152605214C>T	ENST00000367255.5	-	96	18707	c.18106G>A	c.(18106-18108)Gac>Aac	p.D6036N	SYNE1_ENST00000341594.5_Missense_Mutation_p.D5648N|SYNE1_ENST00000423061.1_Missense_Mutation_p.D5965N|SYNE1_ENST00000356820.4_Missense_Mutation_p.D560N|SYNE1_ENST00000448038.1_Missense_Mutation_p.D5965N|SYNE1_ENST00000265368.4_Missense_Mutation_p.D6036N	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6036					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCGCAGGGTCGGCCTCACAA	0.562000										HNSCC(10;0.0054)			20	30					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140438247	140438247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140438247G>A	ENST00000406427.1	-	5	630	c.294C>T	c.(292-294)acC>acT	p.T98T	PNPLA7_ENST00000277531.4_Silent_p.T73T	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	73					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TCTCCACAAGGGTGTTGGGGA	0.602000													25	44					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766568	27766568	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27766568T>A	ENST00000451261.2	+	5	1955	c.1556T>A	c.(1555-1557)cTt>cAt	p.L519H		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						ATAAACTGTCTTGAACCCCAC	0.507000													11	3					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39915756	39915756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39915756C>T	ENST00000425673.1	+	17	4221	c.3896C>T	c.(3895-3897)cCc>cTc	p.P1299L	PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000458508.2_Intron|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.P1328L			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	1328					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCACCACCTCCCCCAGCCAGG	0.741000													4	14					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50599869	50599869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50599869G>A	ENST00000540615.1	+	26	3695	c.3475G>A	c.(3475-3477)Gcc>Acc	p.A1159T	MOV10L1_ENST00000262794.5_Silent_p.E1209E|MOV10L1_ENST00000545383.1_Silent_p.E1209E|MOV10L1_ENST00000395852.1_Silent_p.E336E|MOV10L1_ENST00000395858.3_Silent_p.E1163E	NM_001164105.1	NP_001157577.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	0					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGCATCAGGAGCCCAGCTGAT	0.627000													3	12					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9118220	9118220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9118220G>A	ENST00000377424.4	-	2	302	c.123C>T	c.(121-123)tcC>tcT	p.S41S	SLC2A5_ENST00000535586.1_Intron|SLC2A5_ENST00000377414.3_Silent_p.S41S	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	41					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGTGCTGGGGAGTTGACAG	0.597000													21	31					0	0	1	0	0
TRAF3	7187	broad.mit.edu	37	14	103371731	103371731	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103371731C>T	ENST00000560371.1	+	11	1534	c.1317C>T	c.(1315-1317)tcC>tcT	p.S439S	TRAF3_ENST00000347662.4_Silent_p.S414S|TRAF3_ENST00000539721.1_Silent_p.S356S|TRAF3_ENST00000392745.2_Silent_p.S439S|TRAF3_ENST00000351691.5_Silent_p.S414S	NM_003300.3|NM_145725.2	NP_003291.2|NP_663777.1	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3	439	MATH.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|liver(2)|lung(7)|ovary(1)|prostate(2)	30		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		AGACCCTGTCCCTTTACAGCC	0.577000													35	58					0	0	1	0	0
HEMGN	55363	broad.mit.edu	37	9	100693400	100693400	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:100693400C>T	ENST00000259456.3	-	4	420	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	93					cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				ATTTCCTTTTCTATCTGTGGC	0.443000													24	94					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178554971	178554971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178554971G>A	ENST00000251582.7	-	17	2707	c.2606C>T	c.(2605-2607)cCc>cTc	p.P869L		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	869	TSP type-1 2.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TCCGCCACAGGGCTTGGAGCA	0.612000													15	141					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985516	108985516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108985516C>T	ENST00000392806.3	-	2	812	c.644G>A	c.(643-645)gGg>gAg	p.G215E		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	215						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						TTCCTGGTCCCCCTCCTGGCT	0.687000													25	63					0	0	1	0	0
SOX9	6662	broad.mit.edu	37	17	70120479	70120479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:70120479G>A	ENST00000245479.2	+	3	1853	c.1481G>A	c.(1480-1482)aGc>aAc	p.S494N		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	494					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CAGACCCACAGCCCCCAGCAC	0.607000													10	95					0	0	1	0	0
CRIP1	1396	broad.mit.edu	37	14	105954825	105954825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105954825G>A	ENST00000330233.7	+	4	1154	c.211G>A	c.(211-213)Gcc>Acc	p.A71T	CRIP1_ENST00000409393.2_Missense_Mutation_p.A71T|CRIP1_ENST00000551180.1_Missense_Mutation_p.S39N|CRIP1_ENST00000392531.3_Missense_Mutation_p.A71T			P50238	CRIP1_HUMAN	cysteine-rich protein 1 (intestinal)	71					cell proliferation	cytoplasm	zinc ion binding						Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.235)		GCGGGGCGGAGCCGAGAGCCA	0.642000													21	71					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58209161	58209161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58209161G>A	ENST00000377918.3	+	1	2507	c.2481G>A	c.(2479-2481)caG>caA	p.Q827Q		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	827					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CTGTCCCTCAGGGGCACGCGG	0.602000													13	30					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37769835	37769835	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37769835G>A	ENST00000402918.1	-	3	2525	c.1740C>T	c.(1738-1740)tcC>tcT	p.S580S	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Silent_p.S580S	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	580						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					CTGCAGGGAGGGACTGGCACT	0.657000													11	24					0	0	1	0	0
TMEM198	130612	broad.mit.edu	37	2	220412343	220412343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220412343G>A	ENST00000344458.2	+	4	867	c.282G>A	c.(280-282)gcG>gcA	p.A94A	RP11-256I23.1_ENST00000596829.1_RNA|TMEM198_ENST00000373883.3_Silent_p.A94A			Q66K66	TM198_HUMAN	transmembrane protein 198	94	Leu-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GTGCTGGGGCGAGCGCGGGCA	0.657000													93	165					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7100082	7100082	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7100082G>A	ENST00000399510.2	-	11	2058	c.1206C>T	c.(1204-1206)atC>atT	p.I402I	DLG4_ENST00000399506.2_Silent_p.I359I|DLG4_ENST00000302955.6_Silent_p.I356I	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	359					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						TCACCGACAGGATCTGGTCCC	0.667000													5	4					0	0	1	0	0
GPR113	165082	broad.mit.edu	37	2	26537451	26537451	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26537451C>T	ENST00000333478.6	-	4	948	c.366G>A	c.(364-366)tgG>tgA	p.W122*	GPR113_ENST00000311519.1_Nonsense_Mutation_p.W321*|GPR113_ENST00000421160.2_Nonsense_Mutation_p.W252*|GPR113_ENST00000541401.1_Intron|GPR113_ENST00000459892.1_Intron	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	321					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATACAGGTTCCACTTGAAGC	0.602000													14	38					0	0	1	0	0
GABRD	2563	broad.mit.edu	37	1	1956458	1956458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1956458C>T	ENST00000378585.4	+	2	229	c.146C>T	c.(145-147)gCc>gTc	p.A49V		NM_000815.4	NP_000806.2	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	49						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|lung(8)|ovary(2)|prostate(1)|skin(2)	20	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GGGCTGATAGCCGGCTACGCC	0.677000													12	40					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469108	10469108	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10469108C>T	ENST00000382483.3	-	4	2723	c.2500G>A	c.(2500-2502)Gcc>Acc	p.A834T		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	834					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GCCTCTTGGGCCGGCTGCGTC	0.721000													6	9					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359610	66359610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66359610G>A	ENST00000333861.3	-	1	944	c.877C>T	c.(877-879)Ccc>Tcc	p.P293S		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	293										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CTGCTGGTGGGGGCCACAGGA	0.602000													35	71					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56270365	56270365	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:56270365C>T	ENST00000327381.5	+	2	1034	c.934C>T	c.(934-936)Ctg>Ttg	p.L312L		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	312						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			AGCCACCTTTCTGGAAAGTGC	0.478000													18	47					0	0	1	0	0
GPN3	51184	broad.mit.edu	37	12	110895370	110895370	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110895370A>G	ENST00000543199.1	-	4	596	c.512T>C	c.(511-513)tTc>tCc	p.F171S	GPN3_ENST00000228827.3_Missense_Mutation_p.F132S|GPN3_ENST00000537466.2_Missense_Mutation_p.F142S	NM_001164372.1	NP_001157844.1	Q9UHW5	GPN3_HUMAN	GPN-loop GTPase 3	132						protein complex	GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|urinary_tract(1)	8						ACAGACTCGGAACTCCCACTG	0.393000													20	43					0	0	1	0	0
USP49	25862	broad.mit.edu	37	6	41774231	41774231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41774231C>T	ENST00000394253.3	-	3	820	c.491G>A	c.(490-492)cGg>cAg	p.R164Q	USP49_ENST00000373006.1_Missense_Mutation_p.R164Q|USP49_ENST00000373009.3_Missense_Mutation_p.R164Q|USP49_ENST00000373010.1_Missense_Mutation_p.R164Q|USP49_ENST00000297229.2_Missense_Mutation_p.R164Q			Q70CQ1	UBP49_HUMAN	ubiquitin specific peptidase 49	164					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(2)|skin(2)	23	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGCCTGGCCCCGGGAGCTCTT	0.721000													6	31					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587768	55587768	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55587768C>T	ENST00000333976.4	+	1	683	c.663C>T	c.(661-663)ttC>ttT	p.F221F		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CTTATGCGTTCATTGTTGTAA	0.478000													25	87					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179961271	179961271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179961271C>T	ENST00000367607.3	+	5	728	c.310C>T	c.(310-312)Cgt>Tgt	p.R104C		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	104						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AGAGAAATCTCGTAGTCCTCT	0.398000													3	17					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81647141	81647141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81647141C>T	ENST00000548058.1	+	14	2685	c.1775C>T	c.(1774-1776)cCc>cTc	p.P592L	ACSS3_ENST00000548324.1_Missense_Mutation_p.P274L|ACSS3_ENST00000261206.3_Missense_Mutation_p.P591L			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	592						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						AAGGAAGATCCCTTAAAAGGT	0.398000													53	216					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151729515	151729515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:151729515G>A	ENST00000535741.1	-	32	5814	c.5341C>T	c.(5341-5343)Cca>Tca	p.P1781S	LRBA_ENST00000510413.1_Missense_Mutation_p.P1781S|LRBA_ENST00000357115.3_Missense_Mutation_p.P1781S|LRBA_ENST00000507224.1_Missense_Mutation_p.P1781S			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1781						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TCAACTGTTGGAACTGAGGGC	0.294000													33	69					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377838	55377838	+	Missense_Mutation	SNP	G	G	A	rs138770759	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55377838G>A	ENST00000326321.3	+	8	1152	c.1119G>A	c.(1117-1119)atG>atA	p.M373I	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.M373I|KIR3DL2_ENST00000270442.5_Missense_Mutation_p.M356I	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	373					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		CTGCTGTAATGGACCAAGAGC	0.552000													42	120					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48729211	48729211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48729211G>A	ENST00000316623.5	-	53	6898	c.6443C>T	c.(6442-6444)tCc>tTc	p.S2148F		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2148	EGF-like 36; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCAGCGATAGGAACCATCTGT	0.358000													25	71					0	0	1	0	0
OLR1	4973	broad.mit.edu	37	12	10312586	10312586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10312586G>A	ENST00000309539.3	-	6	775	c.715C>T	c.(715-717)Cct>Tct	p.P239S	OLR1_ENST00000432556.2_3'UTR|OLR1_ENST00000543993.1_3'UTR|OLR1_ENST00000544577.1_Intron|OLR1_ENST00000545927.1_3'UTR	NM_002543.3	NP_002534.1	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like) receptor 1	239	C-type lectin.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						GTACCTGAAGGGTATGTCTGG	0.428000													35	135					0	0	1	0	0
CCDC94	55702	broad.mit.edu	37	19	4268649	4268649	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4268649C>T	ENST00000262962.7	+	8	996	c.928C>T	c.(928-930)Ctg>Ttg	p.L310L		NM_018074.4	NP_060544.2	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	310										NS(1)|endometrium(1)|lung(2)|ovary(1)|stomach(2)	7				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		CCTGAGCCAACTGGGTGCATA	0.622000													7	28					0	0	1	0	0
TBC1D5	9779	broad.mit.edu	37	3	17418070	17418070	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:17418070G>A	ENST00000253692.7	-	10	2312	c.648C>T	c.(646-648)gtC>gtT	p.V216V	TBC1D5_ENST00000429924.2_Silent_p.V168V|TBC1D5_ENST00000429383.4_Silent_p.V216V|TBC1D5_ENST00000446818.2_Silent_p.V216V|TBC1D5_ENST00000414318.2_Intron	NM_014744.2	NP_055559.1	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5	216	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						CACAGTGAAGGACAAAGACTA	0.418000													19	67					0	0	1	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32975941	32975941	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32975941C>T	ENST00000229829.5	-	2	255	c.180G>A	c.(178-180)gtG>gtA	p.V60V	HLA-DOA_ENST00000450833.2_Silent_p.V30V	NM_002119.3	NP_002110.1	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO alpha	60	Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	9						TCTTCAGGTCCACAGAGAACA	0.602000													19	48					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	76055823	76055823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76055823G>A	ENST00000377636.3	-	1	427	c.81C>T	c.(79-81)ggC>ggT	p.G27G	TBC1D4_ENST00000377625.2_Silent_p.G27G|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000431480.2_Silent_p.G27G	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	27						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GCTTCCCGGGGCCGGGCTGAG	0.687000													6	19					0	0	1	0	0
CEP89	84902	broad.mit.edu	37	19	33390817	33390817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33390817G>A	ENST00000305768.4	-	16	1909	c.1821C>T	c.(1819-1821)aaC>aaT	p.N607N		NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	607						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						GGCCAACAAGGTTTGCCAGGT	0.428000													36	100					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489348	133489348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133489348C>T	ENST00000409261.1	-	17	5778	c.5405G>A	c.(5404-5406)aGg>aAg	p.R1802K	NCKAP5_ENST00000405974.3_Missense_Mutation_p.R483K|NCKAP5_ENST00000409213.1_Missense_Mutation_p.R483K|NCKAP5_ENST00000317721.6_Missense_Mutation_p.R1802K	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1802							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTGAAGAGGCCTCATCCCTCT	0.517000													26	50					0	0	1	0	0
NEUROG1	4762	broad.mit.edu	37	5	134870797	134870797	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134870797G>A	ENST00000314744.4	-	1	842	c.584C>T	c.(583-585)cCg>cTg	p.P195L		NM_006161.2	NP_006152.2	Q92886	NGN1_HUMAN	neurogenin 1	195					positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	nucleus	chromatin binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			endometrium(1)|liver(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCAGAGAGCGGGGAGGCGGC	0.716000													6	40					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101971537	101971537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101971537C>T	ENST00000348070.1	-	5	641	c.642G>A	c.(640-642)ctG>ctA	p.L214L	PCSK6_ENST00000331826.7_Silent_p.L49L|PCSK6_ENST00000398181.2_Silent_p.L214L|PCSK6_ENST00000561177.1_5'UTR|PCSK6_ENST00000344273.2_Silent_p.L214L|PCSK6_ENST00000358417.3_Silent_p.L214L	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	215	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AATTTGGGGCCAGGTCAGGGT	0.448000													14	50					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406213	55406213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55406213C>T	ENST00000314612.2	+	1	380	c.380C>T	c.(379-381)cCc>cTc	p.P127L		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						ATTTGCAAGCCCCTGCACTAC	0.423000													23	74					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974415	29974415	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29974415G>A	ENST00000376797.3	-	0	1346				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA																							TGCTGCTCTCGGGGACCCTGG	0.706000													18	41					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178564848	178564848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178564848C>T	ENST00000251582.7	-	12	1974	c.1873G>A	c.(1873-1875)Gag>Aag	p.E625K		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	625	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CGGCACTGCTCCTCGCGGAAG	0.701000													3	5					0	0	1	0	0
ELAC2	60528	broad.mit.edu	37	17	12903528	12903528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12903528G>A	ENST00000338034.4	-	15	1607	c.1368C>T	c.(1366-1368)ttC>ttT	p.F456F	ELAC2_ENST00000426905.3_Silent_p.F416F|ELAC2_ENST00000395962.2_Silent_p.F437F	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	456					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						CGCTCTGCTGGAAGTTGGGAA	0.577000													15	29					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22855192	22855192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22855192C>T	ENST00000283645.4	+	13	1783	c.1653C>T	c.(1651-1653)ttC>ttT	p.F551F	TUBGCP5_ENST00000453949.2_Silent_p.F551F|TUBGCP5_ENST00000559846.1_3'UTR	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	551					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TGGTGTCCTTCCTCAAACCTG	0.542000													18	61					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124439967	124439967	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124439967G>A	ENST00000284287.3	+	1	75	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GCCTTTTAATGGGGTTCTTGT	0.532000													6	53					0	0	1	0	0
OR2AG2	338755	broad.mit.edu	37	11	6790008	6790008	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6790008G>A	ENST00000338569.2	-	1	278	c.181C>T	c.(181-183)Ctc>Ttc	p.L61F		NM_001004490.1	NP_001004490.1	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG, member 2	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(13)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	28		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCAAGCAGGAGGTACATGGGC	0.522000													11	161					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40790031	40790031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40790031C>T	ENST00000373198.3	-	18	2944	c.2709G>A	c.(2707-2709)atG>atA	p.M903I	PTPRT_ENST00000373193.3_Missense_Mutation_p.M884I|PTPRT_ENST00000373184.1_Missense_Mutation_p.M871I|PTPRT_ENST00000373201.1_Missense_Mutation_p.M871I|PTPRT_ENST00000373190.1_Missense_Mutation_p.M880I|PTPRT_ENST00000373187.1_Missense_Mutation_p.M881I|PTPRT_ENST00000356100.2_Missense_Mutation_p.M890I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	881	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCCTCTCTTCATCTGCGTGA	0.562000													28	73					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90129103	90129103	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90129103C>T	ENST00000268138.7	+	4	1446	c.1341C>T	c.(1339-1341)tcC>tcT	p.S447S	TICRR_ENST00000560985.1_Silent_p.S446S|RP11-429B14.1_ENST00000559041.1_RNA					TOPBP1-interacting checkpoint and replication regulator																		ACACAGCTTCCCTTTTCTCAG	0.478000													15	140					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104062929	104062929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104062929G>A	ENST00000265148.3	-	35	5530	c.5441C>T	c.(5440-5442)tCa>tTa	p.S1814L	CENPE_ENST00000380026.3_Missense_Mutation_p.S1789L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1814					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTAGCATTTGAATTTTCTAA	0.313000													4	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179441363	179441363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179441363C>T	ENST00000589042.1	-	325	69832	c.69608G>A	c.(69607-69609)gGa>gAa	p.G23203E	TTN_ENST00000342992.6_Missense_Mutation_p.G20635E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G14138E|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G14330E|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G14263E|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G21562E|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21562	Fibronectin type-III 68.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTGCAGTCCTGTTACTTT	0.443000													87	217					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46967040	46967040	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46967040C>T	ENST00000264318.3	-	8	2063	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	361					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCGGGAACTTCCTGAGGGGGC	0.443000													34	62					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43052897	43052897	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43052897C>T	ENST00000443598.2	+	8	1221	c.1132C>T	c.(1132-1134)Ccg>Tcg	p.P378S	HNF4A_ENST00000316099.3_Intron|HNF4A_ENST00000457232.1_Intron|HNF4A_ENST00000415691.1_Intron	NM_001030004.2|NM_178850.2	NP_001025175.1|NP_849181.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	377					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCTGGGAGGTCCGTGCCAAGC	0.607000													9	19					0	0	1	0	0
IFNA10	3446	broad.mit.edu	37	9	21206699	21206699	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21206699G>A	ENST00000357374.2	-	1	443	c.398C>T	c.(397-399)cCc>cTc	p.P133L		NM_002171.1	NP_002162.1	P01566	IFN10_HUMAN	interferon, alpha 10	133					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|large_intestine(3)|liver(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		ATTCATCAGGGGAGTCTCTTC	0.463000													53	153					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169801120	169801120	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169801120G>A	ENST00000263817.6	-	21	2729	c.2605C>T	c.(2605-2607)Caa>Taa	p.Q869*		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	869	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTCACCCCTTGAACTTGGGAA	0.433000													23	226					0	0	1	0	0
IL12A	3592	broad.mit.edu	37	3	159708044	159708044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159708044C>T	ENST00000305579.2	+	2	516	c.209C>T	c.(208-210)cCa>cTa	p.P70L	IL12A_ENST00000466512.1_Missense_Mutation_p.P70L|IL12A_ENST00000480787.1_Missense_Mutation_p.P70L|CTD-2049J23.2_ENST00000497452.1_RNA	NM_000882.3	NP_000873.2	P29459	IL12A_HUMAN	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	36					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	9			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGAATGTTCCCATGCCTTCAC	0.602000													17	60					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4153809	4153809	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4153809G>A	ENST00000404826.2	+	25	3865	c.3726G>A	c.(3724-3726)ctG>ctA	p.L1242L	SDK1_ENST00000389531.3_Silent_p.L1242L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1242	Fibronectin type-III 6.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCGAGGAGCTGGAGGAGTGGA	0.632000													13	32					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152496920	152496920	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152496920G>A	ENST00000427231.2	-	61	8836	c.8634C>T	c.(8632-8634)ccC>ccT	p.P2878P	NEB_ENST00000409198.1_Silent_p.P2878P|NEB_ENST00000397345.3_Silent_p.P2878P|NEB_ENST00000604864.1_Silent_p.P2878P|NEB_ENST00000172853.10_Silent_p.P2878P|NEB_ENST00000603639.1_Silent_p.P2878P	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2878					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CGCTCTGGTCGGGCAGGCATG	0.547000													70	220					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62298879	62298879	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62298879G>A	ENST00000378024.4	-	5	3284	c.3010C>T	c.(3010-3012)Ccc>Tcc	p.P1004S	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1004					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTAAATTTGGGCATTTTAATC	0.468000													57	152					0	0	1	0	0
FOXB2	442425	broad.mit.edu	37	9	79635164	79635164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79635164C>T	ENST00000376708.1	+	1	594	c.594C>T	c.(592-594)ccC>ccT	p.P198P		NM_001013735.1	NP_001013757.1	Q5VYV0	FOXB2_HUMAN	forkhead box B2	198					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|lung(8)|ovary(1)	10						CGTCACAGCCCCCGCAGCAAC	0.766000													10	17					0	0	1	0	0
HOXD10	3236	broad.mit.edu	37	2	176982006	176982006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:176982006C>T	ENST00000249501.4	+	1	700	c.445C>T	c.(445-447)Cct>Tct	p.P149S	HOXD10_ENST00000490088.2_Intron	NM_002148.3	NP_002139.2	P28358	HXD10_HUMAN	homeobox D10	149						nucleus	sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GGTTCCCGTCCCTGGATATTT	0.537000													62	167					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9382181	9382181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9382181G>A	ENST00000378501.2	+	17	1570	c.1555G>A	c.(1555-1557)Gaa>Aaa	p.E519K	PLCB4_ENST00000414679.2_Missense_Mutation_p.E519K|PLCB4_ENST00000378493.1_Missense_Mutation_p.E519K|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.E519K|PLCB4_ENST00000378473.3_Missense_Mutation_p.E519K|PLCB4_ENST00000334005.3_Missense_Mutation_p.E519K	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	519					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						ATTTGGAAATGAACTTTCTGC	0.458000													18	30					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180043925	180043925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180043925C>T	ENST00000261937.6	-	22	3149	c.3071G>A	c.(3070-3072)gGg>gAg	p.G1024E	FLT4_ENST00000393347.3_Missense_Mutation_p.G1024E|FLT4_ENST00000502649.1_Missense_Mutation_p.G1024E	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1024	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GAACTCCATCCCTCTGGCCAC	0.602000													26	70					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34064204	34064204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34064204C>T	ENST00000389232.4	+	63	8970	c.8900C>T	c.(8899-8901)aCt>aTt	p.T2967I	RYR3_ENST00000415757.3_Missense_Mutation_p.T2967I	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2967					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGGAGAAGACTTCAGAAAAC	0.458000													4	23					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171086461	171086461	+	Missense_Mutation	SNP	C	C	T	rs61008738	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171086461C>T	ENST00000367755.4	+	9	1589	c.1478C>T	c.(1477-1479)tCg>tTg	p.S493L	FMO3_ENST00000538429.1_Missense_Mutation_p.S430L|FMO3_ENST00000542847.1_Missense_Mutation_p.S473L|FMO3_ENST00000392085.2_Missense_Mutation_p.S493L	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	493					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity	p.S493*(1)		endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGGACCGGTCGTTGAAACCC	0.517000													28	49					0	0	1	0	0
CASP9	842	broad.mit.edu	37	1	15844812	15844812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:15844812G>A	ENST00000546424.1	-	2	455	c.211C>T	c.(211-213)Cct>Tct	p.P71S	CASP9_ENST00000348549.5_Missense_Mutation_p.P71S|CASP9_ENST00000333868.5_Missense_Mutation_p.P71S|CASP9_ENST00000375890.4_5'UTR|CASP9_ENST00000469637.1_5'UTR			P55211	CASP9_HUMAN	caspase 9, apoptosis-related cysteine peptidase	71	CARD.				activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|stomach(1)	18		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		ATGAACAAAGGAAGAGCCTGA	0.547000													25	70					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3102863	3102863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3102863C>T	ENST00000378398.3	+	2	294	c.212C>T	c.(211-213)cCt>cTt	p.P71L	PRDM16_ENST00000378391.2_Missense_Mutation_p.P71L|PRDM16_ENST00000442529.2_Missense_Mutation_p.P71L|PRDM16_ENST00000441472.2_Missense_Mutation_p.P71L|PRDM16_ENST00000514189.1_Missense_Mutation_p.P71L|PRDM16_ENST00000270722.5_Missense_Mutation_p.P71L|PRDM16_ENST00000511072.1_Missense_Mutation_p.P71L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	71					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TACGAGGCCCCTGTCTACATT	0.657000			T	EVI1	"""MDS, AML"""								15	129					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84089651	84089651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84089651G>A	ENST00000343411.3	-	22	3416	c.2921C>T	c.(2920-2922)cCc>cTc	p.P974L		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	974					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						AGGGGACAAGGGCCTCACTTG	0.502000													23	57					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231109737	231109737	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231109737C>T	ENST00000392045.3	+	6	720	c.606C>T	c.(604-606)ctC>ctT	p.L202L	SP140_ENST00000417495.3_Silent_p.L202L|SP140_ENST00000343805.6_Silent_p.L202L|SP140_ENST00000486687.2_Silent_p.L202L|SP140_ENST00000350136.5_Silent_p.L182L|SP140_ENST00000420434.3_Silent_p.L202L	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	202					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGTTAGCTCTCCCAAAGGCTG	0.458000													21	66					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25281301	25281301	+	Silent	SNP	C	C	T	rs148902783		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25281301C>T	ENST00000218548.6	+	16	2661	c.2328C>T	c.(2326-2328)ttC>ttT	p.F776F	ATP12A_ENST00000381946.3_Silent_p.F770F	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	770					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ACGACAACTTCGCATCCATCG	0.552000													19	49					0	0	1	0	0
HS3ST3A1	9955	broad.mit.edu	37	17	13503904	13503904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:13503904C>T	ENST00000284110.1	-	1	1340	c.543G>A	c.(541-543)gtG>gtA	p.V181V		NM_006042.1	NP_006033.1	Q9Y663	HS3SA_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	181						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GCTCGGCGCCCACGGCGCGCA	0.721000													3	7					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111319010	111319010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111319010C>T	ENST00000308208.5	+	7	1005	c.763C>T	c.(763-765)Ctc>Ttc	p.L255F	CCDC63_ENST00000550317.1_3'UTR|CCDC63_ENST00000552694.1_Missense_Mutation_p.L176F|CCDC63_ENST00000545036.1_Missense_Mutation_p.L215F	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	255										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GCTGGAGCGTCTCTATGCCCA	0.552000													11	30					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237993860	237993860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237993860G>A	ENST00000366574.2	+	103	15003	c.14686G>A	c.(14686-14688)Gat>Aat	p.D4896N	RYR2_ENST00000360064.6_Missense_Mutation_p.D4902N|RYR2_ENST00000542537.1_Missense_Mutation_p.D4880N|RYR2_ENST00000462585.1_3'UTR	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4896					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATAGGCAATGATTACTTCGA	0.423000													18	147					0	0	1	0	0
FAM120B	84498	broad.mit.edu	37	6	170627575	170627575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:170627575C>T	ENST00000476287.1	+	2	1205	c.1097C>T	c.(1096-1098)cCc>cTc	p.P366L	FAM120B_ENST00000537664.1_Missense_Mutation_p.P389L|FAM120B_ENST00000252510.9_Intron|FAM120B_ENST00000540480.1_Missense_Mutation_p.P378L	NM_032448.1	NP_115824.1	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	366					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(2)	44		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		CGAGAAGTTCCCGTGTATACA	0.527000													78	146					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104136527	104136527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104136527C>T	ENST00000369983.3	+	32	4515	c.4255C>T	c.(4255-4257)Cgg>Tgg	p.R1419W		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1419					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CAAGACTCTCCGGATCTTTGT	0.552000													19	70					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87636167	87636167	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:87636167G>A	ENST00000376214.1	+	21	3270	c.2331_splice	c.e21-1	p.V778_splice	NTRK2_ENST00000376213.1_Splice_Site_p.V762_splice|NTRK2_ENST00000277120.3_Splice_Site_p.V778_splice|NTRK2_ENST00000323115.4_Splice_Site_p.V762_splice	NM_006180.3	NP_006171.2	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	762	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						CTCCATCCAGGTGATAGAGTG	0.527000										TSP Lung(25;0.17)			4	21					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37506752	37506752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37506752G>A	ENST00000374660.1	+	39	3501	c.3402G>A	c.(3400-3402)caG>caA	p.Q1134Q	ANKRD30A_ENST00000602533.1_Silent_p.Q1015Q|ANKRD30A_ENST00000361713.1_Silent_p.Q1015Q			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1109						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AACTTGAACAGGCTCTCAGAA	0.294000													33	33					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50468302	50468302	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50468302G>A	ENST00000331340.3	+	8	1692	c.1537G>A	c.(1537-1539)Gag>Aag	p.E513K	IKZF1_ENST00000359197.5_Missense_Mutation_p.E471K|IKZF1_ENST00000343574.5_Missense_Mutation_p.E426K|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000346667.4_Missense_Mutation_p.E283K|IKZF1_ENST00000438033.1_Missense_Mutation_p.E426K|IKZF1_ENST00000357364.4_Missense_Mutation_p.E426K|IKZF1_ENST00000349824.4_Missense_Mutation_p.E370K|IKZF1_ENST00000439701.1_Missense_Mutation_p.E471K	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	513					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AACGCGAGGGGAGCACCGCTT	0.642000			"""D,T"""	BCL6	"""ALL, DLBCL"""								8	34					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4829647	4829647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4829647G>A	ENST00000354582.6	+	51	6937	c.6587G>A	c.(6586-6588)cGa>cAa	p.R2196Q	ITPR1_ENST00000302640.8_Missense_Mutation_p.R2196Q|ITPR1_ENST00000456211.2_Missense_Mutation_p.R2148Q|ITPR1_ENST00000423119.2_Missense_Mutation_p.R2163Q|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.R2163Q|ITPR1_ENST00000443694.2_Missense_Mutation_p.R2196Q			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2211					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGATTAGACCGAACAATGGAA	0.383000													5	18					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50756563	50756563	+	Silent	SNP	G	G	A	rs75934273		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50756563G>A	ENST00000300589.2	+	8	2850	c.2745G>A	c.(2743-2745)ggG>ggA	p.G915G		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	915					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GTGACGAGGGGGCCCAGGCCC	0.517000													164	349					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79031795	79031795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79031795G>A	ENST00000446378.2	+	2	7238	c.7207G>A	c.(7207-7209)Gaa>Aaa	p.E2403K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2403						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TATCACAAAGGAATCAGAGAA	0.348000													16	48					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74452007	74452007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74452007C>T	ENST00000394019.2	-	28	3603	c.3206G>A	c.(3205-3207)aGg>aAg	p.R1069K	SLC4A5_ENST00000346834.4_Missense_Mutation_p.R988K|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Missense_Mutation_p.R988K|SLC4A5_ENST00000377634.4_Missense_Mutation_p.R1085K|SLC4A5_ENST00000359484.4_Missense_Mutation_p.R967K|SLC4A5_ENST00000357822.5_Missense_Mutation_p.R1085K|SLC4A5_ENST00000358683.4_Missense_Mutation_p.R967K|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1085						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TTTTCTCTTCCTCTTCTTGTC	0.502000													50	151					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168066361	168066361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168066361G>A	ENST00000367838.1	-	5	797	c.484C>T	c.(484-486)Ccc>Tcc	p.P162S	GPR161_ENST00000367835.1_Missense_Mutation_p.P162S|GPR161_ENST00000271357.5_Missense_Mutation_p.P162S|GPR161_ENST00000546300.1_Missense_Mutation_p.P48S|GPR161_ENST00000367836.1_Missense_Mutation_p.P30S|GPR161_ENST00000537209.1_Missense_Mutation_p.P182S|GPR161_ENST00000361697.2_Missense_Mutation_p.P162S|GPR161_ENST00000539777.1_Missense_Mutation_p.P84S	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	162					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CCAAACAGGGGTGGCAGGCAG	0.572000													26	54					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82643420	82643420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:82643420C>T	ENST00000533655.1	+	6	1252	c.1040C>T	c.(1039-1041)cCc>cTc	p.P347L	C11orf82_ENST00000329143.3_Missense_Mutation_p.P46L|C11orf82_ENST00000430323.2_Missense_Mutation_p.P347L|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	347					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						ATGCGAGAGCCCCTTGAGTCA	0.408000													44	150					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121929812	121929812	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:121929812G>A	ENST00000265922.3	-	8	2297	c.1836C>T	c.(1834-1836)ttC>ttT	p.F612F	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		612					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GGACCGTCTCGAAAAATGTTT	0.552000													42	86					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101365178	101365178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101365178C>T	ENST00000392979.3	+	5	807	c.446C>T	c.(445-447)cCt>cTt	p.P149L	ANO4_ENST00000538618.1_Missense_Mutation_p.P350L|ANO4_ENST00000392977.3_Missense_Mutation_p.P184L|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	184						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GTAAGAATGCCTTTCAGGTAG	0.373000										HNSCC(74;0.22)			25	72					0	0	1	0	0
LOC643733	643733	broad.mit.edu	37	11	104774135	104774135	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:104774135C>T	ENST00000532510.1	-	0	3401																											ATCACACTTTCATTTATTTCA	0.388000													8	23					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540419	133540419	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133540419G>A	ENST00000409261.1	-	14	4338	c.3965C>T	c.(3964-3966)tCt>tTt	p.S1322F	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.S1322F	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1322							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTTGTTGGGAGAGCTTTCCGT	0.612000													6	46					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142749482	142749482	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142749482C>T	ENST00000418316.1	+	1	66	c.45C>T	c.(43-45)ttC>ttT	p.F15F		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					TCTTGGGCTTCTCCTCCTTTG	0.512000													49	129					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7847058	7847058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7847058C>T	ENST00000328375.1	-	1	461	c.462G>A	c.(460-462)gtG>gtA	p.V154V	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCCAAGCATTCACACATCCAC	0.473000													36	70					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98363806	98363806	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98363806C>T	ENST00000339364.5	-	15	2290	c.2170_splice	c.e15-1	p.S724_splice	PIK3AP1_ENST00000371110.2_Splice_Site_p.S546_splice|PIK3AP1_ENST00000371109.3_Splice_Site_p.S323_splice	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	724						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		ACTTGTGCTACCTAAAGGGTA	0.453000													5	14					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171384	150171384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150171384G>A	ENST00000307271.3	+	4	1541	c.967G>A	c.(967-969)Ggc>Agc	p.G323S		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	323						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CATCTGTACAGGCCCCCATGC	0.428000													30	72					0	0	1	0	0
FAM114A1	92689	broad.mit.edu	37	4	38907180	38907180	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:38907180C>T	ENST00000358869.2	+	5	650	c.474C>T	c.(472-474)gcC>gcT	p.A158A	FAM114A1_ENST00000515037.1_5'UTR	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1	158						cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						AAGCAGGAGCCACTCTACGGA	0.448000													45	137					0	0	1	0	0
SPAG7	9552	broad.mit.edu	37	17	4864089	4864089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4864089G>A	ENST00000575142.1	-	2	130	c.112C>T	c.(112-114)Cgt>Tgt	p.R38C	SPAG7_ENST00000573366.1_5'UTR|SPAG7_ENST00000206020.3_Missense_Mutation_p.R49C			O75391	SPAG7_HUMAN	sperm associated antigen 7	49						nucleus	nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(3)|ovary(2)|urinary_tract(1)	10						ACCCTTTTACGAAACTCCACT	0.468000													27	57					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8528672	8528672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8528672C>T	ENST00000381196.4	-	12	1003	c.460G>A	c.(460-462)Gat>Aat	p.D154N	PTPRD_ENST00000358503.5_Missense_Mutation_p.D154N|PTPRD_ENST00000397611.3_Missense_Mutation_p.D154N|PTPRD_ENST00000356435.5_Missense_Mutation_p.D154N|PTPRD_ENST00000397617.3_Missense_Mutation_p.D154N|PTPRD_ENST00000397606.3_Missense_Mutation_p.D154N|PTPRD_ENST00000540109.1_Missense_Mutation_p.D154N|PTPRD_ENST00000360074.4_Missense_Mutation_p.D154N|PTPRD_ENST00000463477.1_Missense_Mutation_p.D154N|PTPRD_ENST00000486161.1_Missense_Mutation_p.D154N|PTPRD_ENST00000537002.1_Missense_Mutation_p.D154N|PTPRD_ENST00000355233.5_Missense_Mutation_p.D154N	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	154	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.D154Y(3)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATTTCTGGATCCGGATTACCA	0.483000										TSP Lung(15;0.13)			15	139					0	0	1	0	0
LOC286238	286238	broad.mit.edu	37	9	91262450	91262450	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91262450G>A	ENST00000418343.2	-	0	301																											TATACATAATGAGTTATCATC	0.433000													34	101					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19765374	19765374	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19765374G>A	ENST00000357324.6	-	13	1817	c.1791C>T	c.(1789-1791)gcC>gcT	p.A597A	ATP13A1_ENST00000291503.5_Silent_p.A479A|ATP13A1_ENST00000496082.1_5'UTR	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	597					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						TCCAGTCCACGGCCGTCAGCA	0.672000													14	32					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688639	26688639	+	Missense_Mutation	SNP	C	C	T	rs151261975		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26688639C>T	ENST00000529632.2	+	2	558	c.362C>T	c.(361-363)tCg>tTg	p.S121L	SEZ6L_ENST00000343706.4_Missense_Mutation_p.S121L|SEZ6L_ENST00000360929.3_Missense_Mutation_p.S121L|SEZ6L_ENST00000404234.3_Missense_Mutation_p.S121L|SEZ6L_ENST00000248933.6_Missense_Mutation_p.S121L|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000403121.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	121						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						AAACTGCCTTCGCTCAAGCAG	0.652000													9	33					0	0	1	0	0
IGDCC3	9543	broad.mit.edu	37	15	65623988	65623988	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65623988G>A	ENST00000327987.4	-	8	1409	c.1158C>T	c.(1156-1158)acC>acT	p.T386T	IGDCC3_ENST00000559231.1_5'UTR	NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	386	Ig-like C2-type 4.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TTCCAGAAATGGTCAGTGTGC	0.547000													11	20					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118514600	118514600	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118514600C>T	ENST00000361417.2	+	15	3371	c.2960C>T	c.(2959-2961)tCt>tTt	p.S987F	PHLDB1_ENST00000524713.1_Missense_Mutation_p.S130F|PHLDB1_ENST00000356063.5_Missense_Mutation_p.S940F|PHLDB1_ENST00000527898.1_Missense_Mutation_p.S23F|PHLDB1_ENST00000534672.1_3'UTR	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	987										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		tcctctggctcttcctcctcc	0.652000													29	43					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43847747	43847747	+	Missense_Mutation	SNP	C	C	T	rs150619594		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43847747C>T	ENST00000389420.3	-	12	1722	c.1723G>A	c.(1723-1725)Gga>Aga	p.G575R	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.G575R	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	575	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTTTCGATTCCGCCTCCACAT	0.418000													5	14					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256380	63256380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:63256380G>A	ENST00000323865.3	-	1	1400	c.1167C>T	c.(1165-1167)ggC>ggT	p.G389G	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	389					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGTTGGAGTAGCCCAGCCAAT	0.507000													60	234					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117710337	117710337	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117710337C>T	ENST00000317775.6	-	10	2377	c.1692G>A	c.(1690-1692)ctG>ctA	p.L564L	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.L564L	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	564					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CGTACCACTTCAGCCCCAGGT	0.607000													15	64					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30495221	30495221	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30495221G>A	ENST00000356798.6	+	8	976	c.796G>A	c.(796-798)Gag>Aag	p.E266K	RP11-297C4.2_ENST00000569459.1_RNA|ITGAL_ENST00000358164.5_Missense_Mutation_p.E183K|ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000454514.2_3'UTR	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	266	VWFA.				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CACGGATGGGGAGGCCACTGA	0.582000													28	185					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106693	55106693	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55106693G>A	ENST00000453777.1	+	5	657	c.487G>A	c.(487-489)Gaa>Aaa	p.E163K	LILRA1_ENST00000251372.3_Missense_Mutation_p.E163K|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	163	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		AGGAGAAGATGAACACCCACA	0.587000													56	145					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328747	88328747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:88328747C>T	ENST00000325089.6	+	2	1323	c.1104C>T	c.(1102-1104)tcC>tcT	p.S368S	SLITRK5_ENST00000400028.3_Silent_p.S127S	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	368	LRRNT.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					AGACCAAATCCCCGGTGCCTT	0.597000													15	65					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24877584	24877584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24877584C>T	ENST00000382554.3	+	3	1026	c.708C>T	c.(706-708)tcC>tcT	p.S236S		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	236					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCATGGTGTCCGTGGGAGAGA	0.597000													24	98					0	0	1	0	0
SERPINA12	145264	broad.mit.edu	37	14	94962931	94962931	+	Silent	SNP	G	G	A	rs34365882	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94962931G>A	ENST00000341228.2	-	4	1479	c.684C>T	c.(682-684)ttC>ttT	p.F228F	SERPINA12_ENST00000556881.1_Silent_p.F228F	NM_173850.2	NP_776249.1	Q8IW75	SPA12_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	228					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33				COAD - Colon adenocarcinoma(157;0.235)		TCTCCAGAAAGAAATCTTCCT	0.413000													45	90					0	0	1	0	0
NCCRP1	342897	broad.mit.edu	37	19	39691306	39691306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39691306C>T	ENST00000339852.4	+	6	760	c.738C>T	c.(736-738)ttC>ttT	p.F246F		NM_001001414.1	NP_001001414.1	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	246	FBA.				protein catabolic process					kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	10						TTATCCACTTCCTGCACAAGG	0.627000													115	271					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43319820	43319820	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43319820G>A	ENST00000331495.3	+	16	2334	c.1998G>A	c.(1996-1998)gaG>gaA	p.E666E	FMNL1_ENST00000587489.1_Silent_p.E244E|FMNL1_ENST00000328118.3_Silent_p.E666E	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	666	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						TCAATGATGAGAAGGTGCTGC	0.582000													15	25					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394265	164394265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164394265C>T	ENST00000280605.3	-	1	782	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	208						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCAAAGGCTTCACAGCAATTC	0.517000													19	88					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2421882	2421882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2421882G>A	ENST00000332578.3	+	13	2083	c.2083G>A	c.(2083-2085)Gag>Aag	p.E695K		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	695	Peptidase S1 2.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCTGCGAGGAGGCCCCTGG	0.612000													44	67					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168138055	168138055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168138055C>T	ENST00000519560.1	-	25	2983	c.2564G>A	c.(2563-2565)gGa>gAa	p.G855E	CTC-558O2.1_ENST00000522615.1_RNA|SLIT3_ENST00000332966.8_Missense_Mutation_p.G855E|SLIT3_ENST00000404867.3_Missense_Mutation_p.G855E	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	855					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGGTTGGTTCCCAGCGCCCT	0.597000													3	11					0	0	1	0	0
NKD1	85407	broad.mit.edu	37	16	50667441	50667441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50667441C>T	ENST00000268459.3	+	10	1386	c.1162C>T	c.(1162-1164)Ccg>Tcg	p.P388S		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	388					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GGCTGCCAGCCCGGCCCTCCT	0.716000													4	22					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94056584	94056584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94056584C>T	ENST00000297268.6	+	48	3715	c.3244C>T	c.(3244-3246)Cct>Tct	p.P1082S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	1082					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CATTCGAGGCCCTCAGGGTCA	0.502000										HNSCC(75;0.22)			7	11					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50823956	50823956	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50823956T>C	ENST00000391818.2	-	2	132	c.74A>G	c.(73-75)aAg>aGg	p.K25R	KCNC3_ENST00000474951.1_Silent_p.E4E|KCNC3_ENST00000477616.1_Silent_p.E688E|KCNC3_ENST00000376959.2_Silent_p.E688E			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	649					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GGCTCTTGTCTTCCGGGGACA	0.657000													12	39					0	0	1	0	0
TCEA3	6920	broad.mit.edu	37	1	23724045	23724045	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23724045G>A	ENST00000450454.2	-	7	763	c.657C>T	c.(655-657)atC>atT	p.I219I		NM_003196.1	NP_003187.1	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	219	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		TATGATCTTCGATTTCTGATG	0.498000													33	67					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236205563	236205563	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236205563C>T	ENST00000264187.6	-	4	864	c.782G>A	c.(781-783)tGg>tAg	p.W261*	NID1_ENST00000366595.3_Nonsense_Mutation_p.W261*	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	261	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CTCAAACACCCAGACACCCTG	0.552000													69	228					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108367771	108367771	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108367771A>T	ENST00000361582.3	+	17	2199	c.1969A>T	c.(1969-1971)Agt>Tgt	p.S657C	DZIP3_ENST00000463306.1_Missense_Mutation_p.S657C	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	657					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						CTAGGTTAAGAGTAAACAAAG	0.264000													4	21					0	0	1	0	0
CYP39A1	51302	broad.mit.edu	37	6	46604135	46604135	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46604135A>C	ENST00000275016.2	-	5	926	c.723T>G	c.(721-723)gaT>gaG	p.D241E		NM_016593.3	NP_057677.2	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A, polypeptide 1	241					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity		EIF3K/CYP39A1(2)	NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)	21						CCATGGAATTATCTTTTGCAG	0.274000													16	56					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291465	33291465	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:33291465G>A	ENST00000280979.4	+	13	4616	c.4446G>A	c.(4444-4446)atG>atA	p.M1482I	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1482					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AATTACCAATGATAATGAAAC	0.358000													21	52					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175105061	175105061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175105061G>A	ENST00000239462.4	+	16	3524	c.3411G>A	c.(3409-3411)atG>atA	p.M1137I		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1137	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGGACCCCATGAAGGAGTTCT	0.542000													32	73					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18113038	18113038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18113038C>T	ENST00000403915.1	+	3	1214	c.763C>T	c.(763-765)Ctg>Ttg	p.L255L	KCNS3_ENST00000465292.1_Intron|KCNS3_ENST00000304101.4_Silent_p.L255L			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	255					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GAAAAACCCTCTGAACATCAT	0.512000													31	136					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80782861	80782861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:80782861C>T	ENST00000466387.1	+	16	2308	c.1584C>T	c.(1582-1584)ctC>ctT	p.L528L	CTNNA2_ENST00000540488.1_Silent_p.L528L|CTNNA2_ENST00000496558.1_Silent_p.L528L|CTNNA2_ENST00000402739.4_Silent_p.L528L|CTNNA2_ENST00000343114.3_Silent_p.L207L|CTNNA2_ENST00000361291.4_Silent_p.L562L|CTNNA2_ENST00000541047.1_Silent_p.L528L			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	528					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						TGATAGCCCTCCAAGAGGGCG	0.483000													29	84					0	0	1	0	0
ZNF701	55762	broad.mit.edu	37	19	53085871	53085871	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53085871C>T	ENST00000540331.1	+	5	982	c.757C>T	c.(757-759)Cgt>Tgt	p.R253C	ZNF701_ENST00000301093.2_Missense_Mutation_p.R253C|CTD-3099C6.7_ENST00000599222.1_RNA|ZNF701_ENST00000391785.3_Missense_Mutation_p.R187C	NM_001172655.1	NP_001166126.1	Q9NV72	ZN701_HUMAN	zinc finger protein 701	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(6)	14				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		GCCAAAAACTCGTATTTCTAA	0.383000													33	68					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89650505	89650505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89650505G>A	ENST00000268720.5	+	6	857	c.727G>A	c.(727-729)Gac>Aac	p.D243N	CPNE7_ENST00000319518.8_Missense_Mutation_p.D168N	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	243	C2 2.				lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GAAGCTGGACGACAAGGTGAG	0.677000													6	48					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25467363	25467363	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25467363C>T	ENST00000424208.1	+	0	3097				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						CAGTGTCCATCATCCAGGTGC	0.582000													11	32					0	0	1	0	0
GAL3ST4	79690	broad.mit.edu	37	7	99758461	99758461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99758461G>A	ENST00000360039.4	-	4	943	c.551C>T	c.(550-552)tCt>tTt	p.S184F	GAL3ST4_ENST00000413800.1_Missense_Mutation_p.S184F|GAL3ST4_ENST00000411994.1_Missense_Mutation_p.L83F|GAL3ST4_ENST00000426974.2_Missense_Mutation_p.S122F|GAL3ST4_ENST00000423751.1_Missense_Mutation_p.L83F	NM_024637.4	NP_078913.3	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	184					cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(5)|prostate(1)|upper_aerodigestive_tract(1)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGCAGCCAAAGATGGTGACTT	0.562000													27	78					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182781010	182781010	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182781010C>T	ENST00000431877.2	+	11	2822	c.2643C>T	c.(2641-2643)ttC>ttT	p.F881F	SSFA2_ENST00000409136.1_Silent_p.F390F|SSFA2_ENST00000409001.1_Silent_p.F881F|SSFA2_ENST00000428267.2_Silent_p.F728F|SSFA2_ENST00000320370.7_Silent_p.F881F	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	881						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			GTAGTGCCTTCGCTTCCCCTT	0.517000													11	103					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145627710	145627710	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:145627710C>T	ENST00000296575.3	+	5	1514	c.859C>T	c.(859-861)Ctc>Ttc	p.L287F		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	287						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		ACTGCTAAGCCTCGCATTCCA	0.413000													16	26					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20625847	20625847	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20625847G>A	ENST00000525748.1	+	3	829	c.556G>A	c.(556-558)Gat>Aat	p.D186N		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	186					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CGAGCAAGGGGATGAGAATAA	0.607000													44	112					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120135468	120135468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120135468G>A	ENST00000392521.2	-	46	5933	c.5878C>T	c.(5878-5880)Cgc>Tgc	p.R1960C	CIT_ENST00000261833.7_Missense_Mutation_p.R1918C|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1918					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GGTTACCTGCGGGAGGTGGAC	0.527000													32	132					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18322637	18322637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18322637C>T	ENST00000355502.3	-	18	2594	c.1723G>A	c.(1723-1725)Gag>Aag	p.E575K	PDE4C_ENST00000539010.1_Missense_Mutation_p.E344K|PDE4C_ENST00000594617.2_Missense_Mutation_p.E575K|PDE4C_ENST00000262805.11_Missense_Mutation_p.E543K|PDE4C_ENST00000594465.2_Missense_Mutation_p.E575K|AC068499.10_ENST00000594805.2_RNA|PDE4C_ENST00000447275.2_Missense_Mutation_p.E469K			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	575					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	GACTCACGCTCGCGGTCTCCC	0.627000													37	74					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106769947	106769947	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:106769947G>A	ENST00000276185.4	+	3	228	c.228G>A	c.(226-228)gtG>gtA	p.V76V	FRMPD3-AS1_ENST00000415252.1_RNA			Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	76	PDZ.					cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GGCCTGTGGTGGTTCGATCTG	0.552000													27	35					0	0	1	0	0
PGAM2	5224	broad.mit.edu	37	7	44102378	44102378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44102378C>T	ENST00000297283.3	-	3	804	c.747G>A	c.(745-747)caG>caA	p.Q249Q		NM_000290.3	NP_000281.2	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2 (muscle)	249					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity			large_intestine(2)|lung(4)|ovary(1)|stomach(1)	8						TGGCCTTGCCCTGGGCAGCCA	0.617000													4	42					0	0	1	0	0
PGM2	55276	broad.mit.edu	37	4	37831637	37831637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:37831637G>A	ENST00000381967.4	+	2	233	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	PGM2_ENST00000537241.1_5'UTR|PGM2_ENST00000544359.1_5'UTR	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	45					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						AGGTAATAAAGAAGAACTACG	0.418000													30	61					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33236535	33236535	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33236535G>A	ENST00000401073.2	+	6	1825	c.1755G>A	c.(1753-1755)tcG>tcA	p.S585S	KIAA1522_ENST00000373481.3_Silent_p.S537S|KIAA1522_ENST00000373480.1_Silent_p.S526S|KIAA1522_ENST00000294521.3_Intron	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	526	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GTGGATACTCGAGCCAAAGTG	0.662000													20	32					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476860	20476860	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20476860C>T	ENST00000573854.1	+	3	313	c.199C>T	c.(199-201)Cca>Tca	p.P67S	ACSM2A_ENST00000575690.1_Missense_Mutation_p.P67S|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.P67S|ACSM2A_ENST00000536134.1_5'UTR|ACSM2A_ENST00000424070.1_Missense_Mutation_p.P67S|ACSM2A_ENST00000417235.2_5'UTR|ACSM2A_ENST00000396104.2_Missense_Mutation_p.P67S	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	67					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						ACTCCCAAGCCCAGCCCTGTG	0.537000													18	55					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33134870	33134870	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33134870C>T	ENST00000341947.2	-	58	4434	c.4207G>A	c.(4207-4209)Gat>Aat	p.D1403N	COL11A2_ENST00000357486.1_Missense_Mutation_p.D1382N|COL11A2_ENST00000361917.1_Missense_Mutation_p.D1296N|COL11A2_ENST00000374708.4_Missense_Mutation_p.D1317N|COL11A2_ENST00000395197.1_Missense_Mutation_p.D1343N|COL11A2_ENST00000374712.1_Missense_Mutation_p.D1322N|COL11A2_ENST00000374713.1_Missense_Mutation_p.D1356N|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374714.1_Missense_Mutation_p.D1377N	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1403	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GCTCCAGCATCGCCCCGGAGA	0.612000													8	68					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66816097	66816097	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66816097G>A	ENST00000393946.2	+	11	2297	c.1135G>A	c.(1135-1137)Ggc>Agc	p.G379S	SYT12_ENST00000527043.1_Missense_Mutation_p.G379S|SYT12_ENST00000525457.1_Missense_Mutation_p.G379S			Q8IV01	SYT12_HUMAN	synaptotagmin XII	379	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						CAGCAGCGACGGCCGTGGGGA	0.627000													30	53					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43522383	43522383	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43522383C>T	ENST00000400427.1	+	8	1474	c.1078C>T	c.(1078-1080)Cac>Tac	p.H360Y	UMODL1_ENST00000400424.1_Missense_Mutation_p.H360Y|UMODL1_ENST00000408910.2_Missense_Mutation_p.H432Y|UMODL1_ENST00000408989.2_Missense_Mutation_p.H432Y|C21orf128_ENST00000329015.2_3'UTR	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	432	Fibronectin type-III 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						ACAACTGCTTCACGAGGTAAA	0.458000													19	58					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4732836	4732836	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4732836G>A	ENST00000354582.6	+	32	4187	c.3837G>A	c.(3835-3837)gaG>gaA	p.E1279E	ITPR1_ENST00000302640.8_Silent_p.E1264E|ITPR1_ENST00000456211.2_Silent_p.E1255E|ITPR1_ENST00000423119.2_Silent_p.E1270E|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Silent_p.E1270E|ITPR1_ENST00000443694.2_Silent_p.E1264E			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1279					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGATCCTGGAGGCAGTAACCA	0.443000													3	22					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30926222	30926222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30926222G>A	ENST00000383096.3	-	9	793	c.611C>T	c.(610-612)tCt>tTt	p.S204F	CCDC178_ENST00000402325.1_Missense_Mutation_p.S204F|CCDC178_ENST00000583930.1_Missense_Mutation_p.S204F|CCDC178_ENST00000406524.2_Missense_Mutation_p.S204F|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000579947.1_Missense_Mutation_p.S204F|CCDC178_ENST00000403303.1_Missense_Mutation_p.S204F|CCDC178_ENST00000300227.8_Missense_Mutation_p.S204F					coiled-coil domain containing 178																		GACTGACCAAGAGTCAATTTT	0.368000													34	102					0	0	1	0	0
OR5AU1	390445	broad.mit.edu	37	14	21624046	21624046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21624046C>T	ENST00000304418.3	-	1	176	c.139G>A	c.(139-141)Gag>Aag	p.E47K		NM_001004731.1	NP_001004731.1	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU, member 1	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(12)|pancreas(1)	21	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		CTCCAGTGCTCTGCGATGGAG	0.532000													38	90					0	0	1	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46387758	46387758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46387758G>A	ENST00000302165.3	-	1	1618	c.1275C>T	c.(1273-1275)gcC>gcT	p.A425A		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CATTCTTCAGGGCGGCAATGG	0.711000													14	37					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13729486	13729486	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:13729486T>C	ENST00000354817.3	+	4	549	c.405T>C	c.(403-405)ctT>ctC	p.L135L		NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	135					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						CGCGACAGCTTATTCTCCTTG	0.353000													22	53					0	0	1	0	0
HRASLS2	54979	broad.mit.edu	37	11	63320447	63320447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63320447C>T	ENST00000255695.1	-	4	536	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K		NM_017878.1	NP_060348.1	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	160					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6						TATTGCCTTTCCCGCTTGCTT	0.512000													14	57					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14284465	14284465	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:14284465G>A	ENST00000310358.7	+	0	2739				RP11-21L19.1_ENST00000534587.1_RNA			Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AGGGAGGCCCGAGAGAGCCGG	0.592000													16	39					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64335111	64335111	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64335111C>T	ENST00000301891.4	+	7	1473	c.1099C>T	c.(1099-1101)Ctg>Ttg	p.L367L	SLC22A11_ENST00000377585.3_Intron|SLC22A11_ENST00000377581.3_Silent_p.L367L	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	367					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	GGTCTTCGACCTGCAGAGCCT	0.632000													62	133					0	0	1	0	0
SYPL2	284612	broad.mit.edu	37	1	110018217	110018217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110018217C>T	ENST00000369872.3	+	3	360	c.144C>T	c.(142-144)ttC>ttT	p.F48F	SYPL2_ENST00000401021.3_Silent_p.F48F|SYPL2_ENST00000475497.1_3'UTR	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	48	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		TTGCTATTTTCGCCTTCGGGT	0.547000													20	57					0	0	1	0	0
RPS6KL1	83694	broad.mit.edu	37	14	75388145	75388145	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75388145G>A	ENST00000555647.1	-	3	387	c.100C>T	c.(100-102)Cgc>Tgc	p.R34C	RPS6KL1_ENST00000354625.2_Missense_Mutation_p.R34C|RPS6KL1_ENST00000557413.1_Missense_Mutation_p.R34C|RPS6KL1_ENST00000554900.1_Intron|RPS6KL1_ENST00000358328.4_Missense_Mutation_p.R34C			Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	34						ribosome	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(234;0.00658)		ACCCTGTTGCGAATCTGCTCC	0.627000													14	136					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356729	37356729	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:37356729G>A	ENST00000217420.1	+	2	1288	c.1025G>A	c.(1024-1026)tGg>tAg	p.W342*		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	342					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	ATGATGAACTGGACGCACATC	0.592000													15	47					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555713	155555713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:155555713C>T	ENST00000295101.2	+	1	903	c.426C>T	c.(424-426)gcC>gcT	p.A142A	KCNJ3_ENST00000544049.1_Silent_p.A142A	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	142					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding	p.A142A(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	AGACGGAGGCCACCATCGGCT	0.572000													20	52					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027387	55027387	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:55027387C>T	ENST00000371336.3	+	5	1356	c.1155C>T	c.(1153-1155)tcC>tcT	p.S385S	CASS4_ENST00000360314.3_Silent_p.S385S|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	385	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CATGGTTCTCCAGACGGACAA	0.537000													11	31					0	0	1	0	0
ACTL9	284382	broad.mit.edu	37	19	8807884	8807884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8807884G>A	ENST00000324436.3	-	1	1288	c.1168C>T	c.(1168-1170)Ctg>Ttg	p.L390L		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	390						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						AAGGCGCGCAGGGAGGCCAGG	0.647000													22	50					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110980464	110980464	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110980464C>T	ENST00000524391.1	-	4	2388	c.1356G>A	c.(1354-1356)aaG>aaA	p.K452K	KCNV1_ENST00000297404.1_Silent_p.K452K			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	452						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TGGTAAGCTTCTTTAGGGCTT	0.448000													20	54					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59221500	59221500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59221500G>A	ENST00000262717.4	+	12	2376	c.1978G>A	c.(1978-1980)Gag>Aag	p.E660K	CDH20_ENST00000536675.2_Missense_Mutation_p.E660K|CDH20_ENST00000538374.1_Missense_Mutation_p.E660K			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	660					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				AAACATCCACGAGAACATCGT	0.612000													51	162					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48167728	48167728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48167728C>T	ENST00000311303.3	-	7	1343	c.998G>A	c.(997-999)aGa>aAa	p.R333K	ABCC12_ENST00000416054.1_Missense_Mutation_p.R333K|ABCC12_ENST00000448542.1_Missense_Mutation_p.R333K	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	333	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CAGTAATTTTCTTTCCCTCCT	0.443000													19	45					0	0	1	0	0
POLG2	11232	broad.mit.edu	37	17	62487002	62487002	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62487002G>A	ENST00000539111.2	-	4	947	c.880C>T	c.(880-882)Ccc>Tcc	p.P294S		NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	294					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding	p.P294S(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			TTTCCCCAGGGAAAATTGTAG	0.398000													40	71					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215301392	215301392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215301392G>A	ENST00000312504.5	+	3	1232	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	AC107218.3_ENST00000437883.1_RNA|VWC2L_ENST00000427124.1_Intron|AC107218.3_ENST00000412896.1_RNA	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	144	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						GCCCAGCAATGAAGTTCACTG	0.443000													12	47					0	0	1	0	0
POLDIP3	84271	broad.mit.edu	37	22	42981873	42981873	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42981873G>A	ENST00000252115.5	-	9	1294	c.1190C>T	c.(1189-1191)aCc>aTc	p.T397I	POLDIP3_ENST00000451060.2_3'UTR|POLDIP3_ENST00000339677.6_Intron|POLDIP3_ENST00000348657.2_Missense_Mutation_p.T368I	NM_032311.3	NP_115687.2	Q9BY77	PDIP3_HUMAN	polymerase (DNA-directed), delta interacting protein 3	397					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	16						CTTCAGGATGGTGTCAGGGTC	0.582000													44	91					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9581067	9581067	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9581067C>T	ENST00000301480.4	-	7	662		c.e7+1			NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						GCCAGACTTACCTACTGAGGA	0.438000													27	127					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53215798	53215798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53215798G>A	ENST00000330553.5	-	9	1500	c.1466C>T	c.(1465-1467)tCc>tTc	p.S489F		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	489	Tail.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCCACCCAGGGAGATGCCACC	0.622000													13	57					0	0	1	0	0
FAM188B	84182	broad.mit.edu	37	7	30898886	30898886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30898886C>T	ENST00000265299.6	+	13	1768	c.1691C>T	c.(1690-1692)cCc>cTc	p.P564L	AQP1_ENST00000509504.1_Missense_Mutation_p.P27L|INMT-FAM188B_ENST00000458257.1_3'UTR|AQP1_ENST00000434909.2_5'UTR	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	564										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GAAGTGGGCCCCTATGGCTGC	0.592000													13	86					0	0	1	0	0
CRX	1406	broad.mit.edu	37	19	48343035	48343035	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48343035C>T	ENST00000221996.7	+	4	917	c.711C>T	c.(709-711)ctC>ctT	p.L237L	CRX_ENST00000539067.1_Silent_p.L237L|TPRX2P_ENST00000535362.1_Intron	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	237					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		TTAGCCCCCTCTCTGGCCCCT	0.652000													23	250					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10323457	10323457	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10323457G>A	ENST00000403437.2	-	3	182	c.88C>T	c.(88-90)Caa>Taa	p.Q30*	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	30	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GGCTTGTTTTGGGCCTCAATC	0.478000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				78	103					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14543004	14543004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14543004C>T	ENST00000358970.5	-	1	141	c.142G>A	c.(142-144)Gac>Aac	p.D48N	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	48										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TCGTCGTGGTCTCCAGAAGTG	0.587000													58	299					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49087283	49087283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49087283G>A	ENST00000261900.3	-	9	1936	c.1714C>T	c.(1714-1716)Cgt>Tgt	p.R572C		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	572	Ser-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						CCCCTTTTACGAGTAGAACTG	0.443000													46	121					0	0	1	0	0
FOXL1	2300	broad.mit.edu	37	16	86612425	86612425	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:86612425C>T	ENST00000320241.3	+	1	311	c.96C>T	c.(94-96)ttC>ttT	p.F32F		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	32					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						CTCTGGCCTTCGCCCCCGCGG	0.692000													13	58					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	120053765	120053765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:120053765G>A	ENST00000313400.4	-	2	570	c.470C>T	c.(469-471)tCg>tTg	p.S157L	ASTN2_ENST00000373996.3_Missense_Mutation_p.S157L|ASTN2_ENST00000361209.2_Missense_Mutation_p.S157L|ASTN2_ENST00000361477.3_5'UTR			O75129	ASTN2_HUMAN	astrotactin 2	157						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GTGCACCAGCGAGATGTCCGC	0.627000													11	38					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332740	71332740	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71332740G>A	ENST00000242462.4	-	2	89	c.60C>T	c.(58-60)tcC>tcT	p.S20S		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	20					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						CTCTGGGGAAGGACCGCTCCG	0.672000													24	62					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113377563	113377563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113377563G>A	ENST00000316407.4	-	7	3376	c.2966C>T	c.(2965-2967)tCa>tTa	p.S989L	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.S989L	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	989					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGTATCTGATGAATCTTGCTC	0.393000													41	145					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70530586	70530586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70530586G>A	ENST00000357887.3	-	3	2598	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F	SLC8A3_ENST00000534137.1_Intron|SLC8A3_ENST00000394330.2_Intron|SLC8A3_ENST00000216568.7_Intron|SLC8A3_ENST00000528359.1_Silent_p.F615F|SLC8A3_ENST00000356921.2_Intron|SLC8A3_ENST00000533541.1_Intron|SLC8A3_ENST00000381269.2_Intron	NM_033262.3	NP_150287.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	615	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCATCTCAATGAAGTAATTCT	0.398000													26	79					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	769447	769447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:769447C>T	ENST00000297440.6	+	2	763	c.743C>T	c.(742-744)tCc>tTc	p.S248F	HEATR2_ENST00000313147.5_Missense_Mutation_p.S248F|HEATR2_ENST00000438961.1_3'UTR	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	248							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		GACGTGCTTTCCCATTTTGCT	0.572000													18	37					0	0	1	0	0
SGPP2	130367	broad.mit.edu	37	2	223423135	223423135	+	Missense_Mutation	SNP	G	G	A	rs141548793	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:223423135G>A	ENST00000321276.7	+	5	804	c.718G>A	c.(718-720)Gac>Aac	p.D240N		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	240					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		GACCTTCATCGACTGCCTGGA	0.537000													48	131					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146536809	146536809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:146536809G>A	ENST00000361727.3	+	3	731	c.215G>A	c.(214-216)gGg>gAg	p.G72E		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	72	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCAGGTGCTGGGGGATGGTCT	0.423000										HNSCC(39;0.1)			11	50					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515551	140515551	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140515551C>T	ENST00000231134.5	+	1	752	c.535C>T	c.(535-537)Cat>Tat	p.H179Y		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		179	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCACACTTTCATGTTGCTAC	0.507000													33	83					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24366209	24366209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24366209C>T	ENST00000005284.3	+	3	1553	c.351C>T	c.(349-351)ttC>ttT	p.F117F		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	117					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.F117F(1)		NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		TGCTGTTCTTCGGCGGGCTCT	0.617000													17	42					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49690103	49690103	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49690103G>A	ENST00000296452.4	+	5	3228	c.3114G>A	c.(3112-3114)gaG>gaA	p.E1038E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1038					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCACCATCGAGGACTCCTCAG	0.662000													17	26					0	0	1	0	0
TREH	11181	broad.mit.edu	37	11	118529660	118529660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118529660C>T	ENST00000529101.1	-	13	1544	c.1499G>A	c.(1498-1500)cGa>cAa	p.R500Q	TREH_ENST00000525958.1_Missense_Mutation_p.R469Q|TREH_ENST00000397925.1_Missense_Mutation_p.R469Q|TREH_ENST00000264029.4_Missense_Mutation_p.R500Q|TREH_ENST00000530256.1_Missense_Mutation_p.R377Q			O43280	TREA_HUMAN	trehalase (brush-border membrane glycoprotein)	500					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity	p.R500P(1)		NS(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		AAAATTGGTTCGGATCCAATT	0.587000													67	139					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92600089	92600089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92600089C>T	ENST00000298047.6	+	21	11858	c.11841C>T	c.(11839-11841)ttC>ttT	p.F3947F	FAT3_ENST00000533797.1_Silent_p.F282F|FAT3_ENST00000409404.2_Silent_p.F3947F|FAT3_ENST00000525166.1_Silent_p.F3797F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3947	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCCTCTACTTCCAGACGCTGA	0.632000										TCGA Ovarian(4;0.039)			6	27					0	0	1	0	0
C6orf195	154386	broad.mit.edu	37	6	2624022	2624022	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:2624022G>A	ENST00000296847.3	-	3	558	c.35C>T	c.(34-36)cCc>cTc	p.P12L		NM_152554.2	NP_689767.2	Q96MT4	CF195_HUMAN	chromosome 6 open reading frame 195	12										cervix(1)|endometrium(1)|lung(2)|skin(1)	5	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				CTGCTTCCAGGGAATGTTCCT	0.507000													13	53					0	0	1	0	0
CHST4	10164	broad.mit.edu	37	16	71571673	71571673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71571673G>A	ENST00000338482.5	+	3	1436	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K	CHST4_ENST00000539698.3_Missense_Mutation_p.E365K|CHST4_ENST00000572450.1_Missense_Mutation_p.E365K|RP11-510M2.9_ENST00000572693.1_RNA|ZNF19_ENST00000568446.1_Intron			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	365					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						CGTCAGATCTGAACAAGAACA	0.522000											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	71					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53617456	53617456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:53617456G>A	ENST00000342160.3	-	34	4556	c.4099C>T	c.(4099-4101)Ctc>Ttc	p.L1367F	HUWE1_ENST00000218328.8_Missense_Mutation_p.L1367F|HUWE1_ENST00000262854.6_Missense_Mutation_p.L1367F			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1367					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GACATGCTGAGATCCTAGAGT	0.438000													11	54					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18671986	18671986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18671986C>T	ENST00000308799.4	+	9	2150	c.1931C>T	c.(1930-1932)cCc>cTc	p.P644L	FBXW10_ENST00000395665.4_Missense_Mutation_p.P615L|FBXW10_ENST00000301938.4_Missense_Mutation_p.P615L|FBXW10_ENST00000395667.1_Missense_Mutation_p.P615L			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	615										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						TTCAAGCATCCCAAGTAGGTG	0.567000													24	16					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169696610	169696610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169696610C>T	ENST00000333360.7	-	10	1664	c.1525G>A	c.(1525-1527)Gag>Aag	p.E509K	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367775.1_Missense_Mutation_p.E384K|SELE_ENST00000367774.1_Missense_Mutation_p.E383K|SELE_ENST00000367782.4_Missense_Mutation_p.E446K|SELE_ENST00000367779.4_Missense_Mutation_p.E383K|SELE_ENST00000367781.4_Missense_Mutation_p.E446K|SELE_ENST00000367777.1_Missense_Mutation_p.E446K|SELE_ENST00000367776.1_Missense_Mutation_p.E446K|SELE_ENST00000367780.4_Missense_Mutation_p.E384K	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	509	Sushi 6.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					AACACGGGCTCCCCACTGCAG	0.522000													16	47					0	0	1	0	0
H1FOO	132243	broad.mit.edu	37	3	129267879	129267879	+	Silent	SNP	G	G	A	rs145471008		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129267879G>A	ENST00000324382.2	+	3	419	c.414G>A	c.(412-414)agG>agA	p.R138R	H1FOO_ENST00000503977.1_5'UTR	NM_153833.1	NP_722575.1	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	138					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding	p.R138R(1)		endometrium(1)|lung(4)|skin(1)	6						TCCAGCCCAGGAAGATGGCCC	0.647000													5	30					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21035984	21035984	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21035984C>T	ENST00000261383.3	-	39	5579	c.5580G>A	c.(5578-5580)tgG>tgA	p.W1860*	DNAH3_ENST00000415178.1_Nonsense_Mutation_p.W1860*	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1860	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCAGGGGCTTCCAGCCTAGTT	0.532000													4	47					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152383212	152383212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152383212C>T	ENST00000271835.3	-	3	408	c.346G>A	c.(346-348)Gga>Aga	p.G116R	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	116					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTCTCTGTCCTTCGCCCAGC	0.617000													159	301					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9091556	9091556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9091556G>A	ENST00000397910.4	-	1	462	c.259C>T	c.(259-261)Cct>Tct	p.P87S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	87	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGACTCAGGGAGAGCAGAG	0.537000													40	80					0	0	1	0	0
RELB	5971	broad.mit.edu	37	19	45540982	45540982	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45540982C>T	ENST00000221452.8	+	12	1824	c.1674C>T	c.(1672-1674)ttC>ttT	p.F558F	RELB_ENST00000505236.1_Silent_p.F555F|RELB_ENST00000540120.1_Silent_p.F558F	NM_006509.3	NP_006500.2	Q01201	RELB_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog B	558						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(3)|skin(1)	12		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		GCAACATGTTCCCCAATCATT	0.697000													5	27					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35400426	35400426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35400426C>T	ENST00000378495.3	+	36	4445	c.4223C>T	c.(4222-4224)tCg>tTg	p.S1408L	UNC13B_ENST00000378496.4_Missense_Mutation_p.S1408L|UNC13B_ENST00000396787.1_Missense_Mutation_p.S1420L	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	1408					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity	p.S1408*(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TTTGTGCGCTCGCAGACCACC	0.527000													70	121					0	0	1	0	0
GTF2H3	2967	broad.mit.edu	37	12	124135583	124135583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124135583C>T	ENST00000543341.2	+	5	438	c.407C>T	c.(406-408)tCc>tTc	p.S136F	GTF2H3_ENST00000228955.7_Missense_Mutation_p.S95F	NM_001271867.1|NM_001516.3	NP_001258796.1|NP_001507.2	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3, 34kDa	136					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		CTGGCAGGATCCCTGGCCAAA	0.368000								Nucleotide excision repair (NER)					23	44					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1507763	1507763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1507763C>T	ENST00000345913.4	+	14	2521	c.2430C>T	c.(2428-2430)gcC>gcT	p.A810A	TPO_ENST00000382198.1_Silent_p.A637A|TPO_ENST00000349624.3_Silent_p.A637A|TPO_ENST00000329066.4_Silent_p.A810A|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000382201.3_Silent_p.A753A|TPO_ENST00000337415.3_Silent_p.A810A|TPO_ENST00000346956.3_Intron	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	810	EGF-like; calcium-binding (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCTGCCACGCCTCTGCGAGGT	0.627000													21	43					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4445806	4445806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4445806G>A	ENST00000254718.4	-	22	3346	c.3040C>T	c.(3040-3042)Ccc>Tcc	p.P1014S	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.P1014S			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	1014					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						ACCAGGATGGGGAGCAGGCTC	0.637000													32	40					0	0	1	0	0
TRAJ9	28746	broad.mit.edu	37	14	23004532	23004532	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23004532G>A	ENST00000390528.1	+	0	31																											AACTATCTTTGGAGCAGGAAC	0.373000													13	60					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16242248	16242248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:16242248G>A	ENST00000339732.5	+	3	1332	c.829G>A	c.(829-831)Gat>Aat	p.D277N	GALNT15_ENST00000437509.1_Missense_Mutation_p.D277N	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		AGCCACCGGGGATGTGCTCGT	0.622000													17	30					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105797580	105797580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:105797580C>T	ENST00000393127.2	+	13	2407	c.1961C>T	c.(1960-1962)cCc>cTc	p.P654L	GRIA4_ENST00000525187.1_Missense_Mutation_p.P654L|GRIA4_ENST00000282499.5_Missense_Mutation_p.P654L|GRIA4_ENST00000530497.1_Missense_Mutation_p.P654L	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	654					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity	p.P654L(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATGGTCTCTCCCATAGAAAGT	0.418000													14	52					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123843062	123843062	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123843062C>T	ENST00000369005.1	+	4	1387	c.1047C>T	c.(1045-1047)ggC>ggT	p.G349G	TACC2_ENST00000334433.3_Silent_p.G349G|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Silent_p.G349G|TACC2_ENST00000515273.1_Silent_p.G349G|TACC2_ENST00000453444.2_Silent_p.G349G	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	349						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGCCCTGGGGCTTGCCAAGTC	0.627000													22	65					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31565099	31565099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31565099C>T	ENST00000379416.3	-	32	3517	c.3469G>A	c.(3469-3471)Ggg>Agg	p.G1157R		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	1157					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CAAGCCACCCCATAGCTGAAG	0.443000													37	97					0	0	1	0	0
GNGT2	2793	broad.mit.edu	37	17	47284190	47284190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47284190C>T	ENST00000511277.1	-	4	318	c.139G>A	c.(139-141)Gat>Aat	p.D47N	GNGT2_ENST00000511673.1_Missense_Mutation_p.D47N|GNGT2_ENST00000503070.1_Missense_Mutation_p.D47N|GNGT2_ENST00000515635.1_Missense_Mutation_p.D47N|GNGT2_ENST00000300406.2_Missense_Mutation_p.D47N|GNGT2_ENST00000507680.1_Missense_Mutation_p.D47N	NM_001198756.1	NP_001185685.1	O14610	GBGT2_HUMAN	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	47					G-protein coupled receptor protein signaling pathway|phototransduction|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity			endometrium(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			AGAAAAGGATCGTTTCCTGCT	0.488000													28	90					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80366371	80366371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:80366371G>A	ENST00000265080.4	+	4	671	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	202					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CCAAGAAGACGAAGATCCAGA	0.428000													35	80					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55452895	55452895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55452895G>A	ENST00000446217.1	-	4	671	c.269C>T	c.(268-270)tCc>tTc	p.S90F	NLRP7_ENST00000592784.1_Missense_Mutation_p.S62F|NLRP7_ENST00000340844.2_Missense_Mutation_p.S62F|NLRP7_ENST00000588756.1_Missense_Mutation_p.S62F|NLRP7_ENST00000448121.2_Missense_Mutation_p.S62F|NLRP7_ENST00000328092.5_Missense_Mutation_p.S62F|NLRP7_ENST00000590030.1_Missense_Mutation_p.S62F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	62	DAPIN.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		ATTTTCTGAGGAGGTGTTGAC	0.468000													40	76					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420603	53420603	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:53420603C>T	ENST00000377942.3	-	1	2172	c.1969G>A	c.(1969-1971)Gag>Aag	p.E657K	PCDH8_ENST00000338862.4_Missense_Mutation_p.E657K	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	657	Cadherin 6.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TCGCGCGGCTCCTGCTGCTGC	0.711000													13	24					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105174066	105174066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105174066C>T	ENST00000369797.3	+	11	1444	c.1350C>T	c.(1348-1350)atC>atT	p.I450I		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	450					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ATCATGACATCGAACCTGGGG	0.443000													18	37					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86049712	86049712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:86049712C>T	ENST00000414626.2	+	14	3172	c.2283C>T	c.(2281-2283)gcC>gcT	p.A761A	LRRCC1_ENST00000360375.3_Silent_p.A781A			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	781					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						CTTCTCTAGCCCAAAATCGTG	0.318000													18	74					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248616152	248616152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248616152C>T	ENST00000342927.3	+	1	76	c.54C>T	c.(52-54)ctC>ctT	p.L18L		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCACAGGCCTCATCACCCATC	0.517000													38	173					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14378223	14378223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:14378223C>T	ENST00000403951.2	-	23	2461	c.2042G>A	c.(2041-2043)cGa>cAa	p.R681Q	DGKB_ENST00000402815.1_Missense_Mutation_p.R680Q|DGKB_ENST00000258767.5_Missense_Mutation_p.R681Q|DGKB_ENST00000444700.2_Missense_Mutation_p.R662Q|DGKB_ENST00000399322.3_Missense_Mutation_p.R681Q|DGKB_ENST00000407950.1_Missense_Mutation_p.R673Q|DGKB_ENST00000406247.3_Missense_Mutation_p.R681Q|DGKB_ENST00000403963.1_5'UTR			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	681					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding	p.R681Q(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	TCGATGGCTTCGTCTTTTCTT	0.398000													36	81					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120989131	120989131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120989131G>A	ENST00000392793.1	+	7	1178	c.907G>A	c.(907-909)Gag>Aag	p.E303K	TECTA_ENST00000264037.2_Missense_Mutation_p.E303K			O75443	TECTA_HUMAN	tectorin alpha	303	VWFC.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix		p.E303K(1)	TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TAGCCCCTACGAGGTGTGCGA	0.537000													27	67					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2705044	2705044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2705044C>T	ENST00000399655.1	+	20	2933	c.2668C>T	c.(2668-2670)Cgc>Tgc	p.R890C	CACNA1C_ENST00000399637.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000480911.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000335762.5_Missense_Mutation_p.R915C|CACNA1C_ENST00000399603.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399649.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399595.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399606.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399601.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399617.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000344100.3_Missense_Mutation_p.R890C|CACNA1C_ENST00000399621.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399629.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000327702.7_Missense_Mutation_p.R890C|CACNA1C_ENST00000406454.3_Missense_Mutation_p.R890C|CACNA1C_ENST00000402845.3_Missense_Mutation_p.R890C|CACNA1C_ENST00000399597.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000347598.4_Missense_Mutation_p.R890C|CACNA1C_ENST00000399641.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399638.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399644.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399591.1_Missense_Mutation_p.R890C|CACNA1C_ENST00000399634.1_Missense_Mutation_p.R890C	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	890					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GTACAGGTTTCGCCTCCAGTG	0.582000													34	80					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227983423	227983423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227983423C>T	ENST00000396625.3	-	7	634	c.427G>A	c.(427-429)Ggc>Agc	p.G143S	COL4A4_ENST00000329662.7_Missense_Mutation_p.G143S	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	143	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTCTTGAGCCATTGTGGCCA	0.502000													27	78					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6228308	6228308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6228308C>T	ENST00000262450.3	-	2	208	c.109G>A	c.(109-111)Gat>Aat	p.D37N	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	37					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AAAAAGTCATCGAAGGCTTCA	0.493000													77	198					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501994	140501994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140501994C>T	ENST00000194152.1	+	1	414	c.414C>T	c.(412-414)ctC>ctT	p.L138L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		138	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGAAGTGCTCTTGAAAATAC	0.408000													30	86					0	0	1	0	0
P2RY6	5031	broad.mit.edu	37	11	73007962	73007962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73007962C>T	ENST00000393590.2	+	2	698	c.399C>T	c.(397-399)gcC>gcT	p.A133A	P2RY6_ENST00000349767.2_Silent_p.A133A|P2RY6_ENST00000540124.1_Silent_p.A133A|P2RY6_ENST00000538328.1_Silent_p.A133A|P2RY6_ENST00000542092.1_Silent_p.A133A|P2RY6_ENST00000393591.1_Silent_p.A133A|P2RY6_ENST00000540342.1_Silent_p.A133A|P2RY6_ENST00000393592.2_Silent_p.A133A	NM_001277207.1|NM_001277208.1	NP_001264136.1|NP_001264137.1	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y, G-protein coupled, 6	133					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)	14						ACCCGCTGGCCCCCTGGCACA	0.657000													8	88					0	0	1	0	0
GCNT3	9245	broad.mit.edu	37	15	59910953	59910953	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:59910953C>T	ENST00000396065.1	+	3	964	c.516C>T	c.(514-516)ttC>ttT	p.F172F	GCNT3_ENST00000560585.1_Silent_p.F172F	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	172					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CAGAAACTTTCAAAGAGGCGG	0.463000													27	121					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41145444	41145444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41145444G>A	ENST00000344051.4	+	3	832	c.598G>A	c.(598-600)Gta>Ata	p.V200I	SPINT1_ENST00000431806.1_Missense_Mutation_p.V200I|SPINT1_ENST00000562057.1_Missense_Mutation_p.V200I			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	200						extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GGATGTCAGGGTAGAGGTGAG	0.612000													22	67					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143959	56143959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56143959C>T	ENST00000302270.1	+	1	860	c.860C>T	c.(859-861)cCc>cTc	p.P287L		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					ATGTTGAATCCCTTAATCTAT	0.373000													17	214					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861758	52861758	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52861758C>G	ENST00000343457.3	-	4	1436	c.1430G>C	c.(1429-1431)aGg>aCg	p.R477T		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	477						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						CTTTCTGCTCCTTCCCAGAGT	0.542000													27	89					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75051446	75051446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75051446C>T	ENST00000310715.3	-	19	2302	c.2182G>A	c.(2182-2184)Gat>Aat	p.D728N	TTC18_ENST00000355577.3_Missense_Mutation_p.D197N|TTC18_ENST00000394865.1_Missense_Mutation_p.D728N|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000401621.2_Missense_Mutation_p.D728N|TTC18_ENST00000493787.1_5'UTR	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	728							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CAAGTAGCATCCTCAAAGAAA	0.393000													12	27					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32272248	32272248	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32272248C>T	ENST00000400246.1	+	37	3944	c.3802C>T	c.(3802-3804)Cga>Tga	p.R1268*	DEPDC5_ENST00000535622.1_Nonsense_Mutation_p.R1168*|DEPDC5_ENST00000382111.2_Nonsense_Mutation_p.R1268*|DEPDC5_ENST00000400248.1_Nonsense_Mutation_p.R1237*|DEPDC5_ENST00000400249.2_Nonsense_Mutation_p.R1237*|DEPDC5_ENST00000266091.3_Nonsense_Mutation_p.R1246*|DEPDC5_ENST00000382105.2_Intron|DEPDC5_ENST00000382112.3_Nonsense_Mutation_p.R1259*|DEPDC5_ENST00000539165.1_Nonsense_Mutation_p.R85*			O75140	DEPD5_HUMAN	DEP domain containing 5	1237					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						AGAGCCCGACCGAGGTTAGAG	0.532000													45	90					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848171	123848171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123848171C>T	ENST00000531945.1	-	1	317	c.228G>A	c.(226-228)ctG>ctA	p.L76L		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AGAGGTGCCCCAGGAAGTGGT	0.547000													12	36					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31341692	31341692	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31341692G>A	ENST00000544665.3	+	27	3198	c.3127G>A	c.(3127-3129)Gaa>Aaa	p.E1043K	ITGAM_ENST00000287497.8_Missense_Mutation_p.E1042K	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1042					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CATCCAGGAAGAATTCAATGC	0.582000													27	69					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220472776	220472776	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220472776C>T	ENST00000456909.1	+	14	1317	c.1227C>T	c.(1225-1227)ttC>ttT	p.F409F	STK11IP_ENST00000295641.10_Silent_p.F420F			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	420					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGGATGGTTCGTGCAGCAGC	0.627000													24	30					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115412772	115412772	+	Silent	SNP	G	G	A	rs149492667		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115412772G>A	ENST00000369358.4	-	6	736	c.492C>T	c.(490-492)ccC>ccT	p.P164P	NRAP_ENST00000360478.3_Silent_p.P164P|NRAP_ENST00000369360.3_Silent_p.P164P|NRAP_ENST00000359988.3_Silent_p.P164P			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	164						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CCTTGCCCCTGGGTTGCTCAT	0.473000													35	96					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51446170	51446170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51446170G>A	ENST00000298355.3	-	9	3126	c.2005C>T	c.(2005-2007)Ccc>Tcc	p.P669S	TRIM9_ENST00000338969.5_Missense_Mutation_p.P750S	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	669	B30.2/SPRY.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					AATGCTATGGGACCTTGTTGT	0.488000													78	166					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332700	70332700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70332700C>T	ENST00000338508.4	-	32	3700	c.3701G>A	c.(3700-3702)gGa>gAa	p.G1234E	SHANK2_ENST00000449833.2_Missense_Mutation_p.G638E|SHANK2_ENST00000423696.2_Missense_Mutation_p.G854E|SHANK2_ENST00000409161.1_Missense_Mutation_p.G637E			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	854					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCCTTTGGGTCCCTGTTGAGA	0.607000													50	79					0	0	1	0	0
GIN1	54826	broad.mit.edu	37	5	102440250	102440250	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:102440250G>A	ENST00000399004.2	-	4	728	c.634C>T	c.(634-636)Caa>Taa	p.Q212*	GIN1_ENST00000511400.1_5'UTR|GIN1_ENST00000508629.1_Nonsense_Mutation_p.Q212*	NM_017676.2	NP_060146.2	Q9NXP7	GIN1_HUMAN	gypsy retrotransposon integrase 1	212	Integrase catalytic.				DNA integration		DNA binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		CTTACCTGTTGAATGAATTCA	0.343000													8	21					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155450803	155450803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155450803C>T	ENST00000461783.3	+	6	1719	c.446C>T	c.(445-447)tCc>tTc	p.S149F	TIAM2_ENST00000456144.1_Missense_Mutation_p.S149F|TIAM2_ENST00000318981.5_Missense_Mutation_p.S149F|TIAM2_ENST00000360366.4_Missense_Mutation_p.S149F|TIAM2_ENST00000529824.2_Missense_Mutation_p.S149F|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	149					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGCATTGCCTCCACCCCACCG	0.572000													15	25					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148112648	148112648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148112648G>A	ENST00000361727.3	+	24	4452	c.3936G>A	c.(3934-3936)atG>atA	p.M1312I	CNTNAP2_ENST00000463592.2_3'UTR|CNTNAP2_ENST00000538075.1_Missense_Mutation_p.M371I	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1312					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCGCCATCATGAACAACGACC	0.542000										HNSCC(39;0.1)			14	81					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24669876	24669876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24669876G>A	ENST00000376454.3	+	3	463	c.433G>A	c.(433-435)Gct>Act	p.A145T	KIAA1217_ENST00000458595.1_Missense_Mutation_p.A145T|KIAA1217_ENST00000430453.2_Missense_Mutation_p.A66T|KIAA1217_ENST00000376462.1_Missense_Mutation_p.A65T|KIAA1217_ENST00000376452.3_Missense_Mutation_p.A145T	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	145			A -> G (in dbSNP:rs17506606).		embryonic skeletal system development	cytoplasm		p.A145T(1)		breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AGAGACGTCCGCTGATTCTTT	0.542000													21	80					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960273	73960273	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73960273T>A	ENST00000373468.1	-	3	4770	c.4119A>T	c.(4117-4119)acA>acT	p.T1373T	KIAA2022_ENST00000055682.5_Silent_p.T1373T			Q5QGS0	K2022_HUMAN	KIAA2022	1373					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						ACTCCTGTGGTGTCCCAGCCA	0.458000													43	29					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69935090	69935090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:69935090G>A	ENST00000358913.5	+	12	3063	c.2575G>A	c.(2575-2577)Gga>Aga	p.G859R	MYPN_ENST00000354393.2_Missense_Mutation_p.G584R|MYPN_ENST00000540630.1_Missense_Mutation_p.G859R	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	859						nucleus|sarcomere	actin binding	p.G859R(1)		breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GCCATCCCAGGGATTAGCGAA	0.423000													21	35					0	0	1	0	0
HAL	3034	broad.mit.edu	37	12	96389457	96389457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:96389457C>T	ENST00000261208.3	-	2	600	c.232G>A	c.(232-234)Gag>Aag	p.E78K	HAL_ENST00000541929.1_5'UTR|HAL_ENST00000538703.1_Missense_Mutation_p.E78K	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	78					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	TCCACGAACTCGTTGTTCTCT	0.627000													7	66					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50827018	50827018	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50827018G>A	ENST00000376959.2	-	2	1355	c.1192C>T	c.(1192-1194)Ctc>Ttc	p.L398F	KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000477616.1_Missense_Mutation_p.L398F|KCNC3_ENST00000391818.2_Intron			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	398					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		AGGCCCGAGAGGCCCACCTCG	0.597000													25	37					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16385458	16385458	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:16385458C>T	ENST00000354981.2	-	17	1941	c.1784_splice	c.e17+1	p.G595_splice	KIF16B_ENST00000408042.1_Splice_Site_p.G595_splice|KIF16B_ENST00000355755.3_Splice_Site_p.G595_splice|KIF16B_ENST00000378003.2_5'UTR	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	595					cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						GTTCACTCACCCGGGGTTATA	0.478000													10	29					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100774643	100774643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100774643C>T	ENST00000323346.5	+	2	579	c.266C>T	c.(265-267)tCc>tTc	p.S89F	SLC17A8_ENST00000392989.3_Missense_Mutation_p.S89F	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	89					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TTCTGCATTTCCTTTGGGATC	0.517000													28	127					0	0	1	0	0
RPUSD3	285367	broad.mit.edu	37	3	9882454	9882454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9882454G>A	ENST00000383820.5	-	5	444	c.443C>T	c.(442-444)cCc>cTc	p.P148L	RPUSD3_ENST00000433535.2_Missense_Mutation_p.P133L|TTLL3_ENST00000455274.1_Intron|RPUSD3_ENST00000424438.1_Missense_Mutation_p.P116L	NM_173659.3	NP_775930.2	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	148					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(2)|endometrium(3)|lung(2)	7	Medulloblastoma(99;0.227)					AGCTGTCTGGGGACAGCTGGA	0.527000													8	30					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45005740	45005740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:45005740G>A	ENST00000258787.7	-	16	2225	c.2089C>T	c.(2089-2091)Cgg>Tgg	p.R697W		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	697						myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						ACCAGTGTCCGGGGTGAGCGG	0.642000													10	37					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	633625	633625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:633625C>T	ENST00000026218.5	+	10	2362	c.2274C>T	c.(2272-2274)gtC>gtT	p.V758V	PIGQ_ENST00000321878.5_3'UTR	NM_148920.2	NP_683721.1	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	758					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				CTGGAGAGGTCGCTTTGTGAA	0.647000													24	52					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13882840	13882840	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13882840G>A	ENST00000265104.4	-	21	3363	c.3259C>T	c.(3259-3261)Caa>Taa	p.Q1087*	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1087	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CATTTACCTTGAAGTTCATTT	0.303000									Kartagener syndrome				6	46					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62536530	62536530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:62536530G>A	ENST00000430451.2	+	2	930	c.733G>A	c.(733-735)Gaa>Aaa	p.E245K	RP11-355I22.5_ENST00000553990.1_lincRNA|SYT16_ENST00000446982.2_Missense_Mutation_p.E245K	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	245										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		ATCTGCCTGCGAAGGTATCCT	0.483000													12	48					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121008491	121008491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121008491C>T	ENST00000392793.1	+	11	3574	c.3303C>T	c.(3301-3303)atC>atT	p.I1101I	TECTA_ENST00000264037.2_Silent_p.I1101I			O75443	TECTA_HUMAN	tectorin alpha	1101	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCTCCTGCATCGTCTCAGGCT	0.587000													20	30					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52256720	52256720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52256720C>T	ENST00000597542.1	-	9	2641	c.1684G>A	c.(1684-1686)Gag>Aag	p.E562K	TLR9_ENST00000494383.1_Missense_Mutation_p.R691Q|TLR9_ENST00000360658.2_Missense_Mutation_p.E538K			Q9NR96	TLR9_HUMAN	toll-like receptor 9	538					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	AATGAGTGCTCGTGGTAGAGG	0.602000													12	42					0	0	1	0	0
ATF7IP2	80063	broad.mit.edu	37	16	10525053	10525053	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10525053G>A	ENST00000396560.2	+	3	803	c.576G>A	c.(574-576)aaG>aaA	p.K192K	ATF7IP2_ENST00000356427.2_Silent_p.K192K|ATF7IP2_ENST00000396559.1_Silent_p.K192K|ATF7IP2_ENST00000543967.1_Intron|ATF7IP2_ENST00000324570.5_Silent_p.K192K	NM_024997.3	NP_079273.2	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting protein 2	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				large_intestine(3)	3						TGGGTGACAAGAAAACTGACC	0.423000													10	102					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45132974	45132974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45132974G>A	ENST00000296129.1	-	7	1818	c.1684C>T	c.(1684-1686)Ccc>Tcc	p.P562S		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	562						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCCCAGTTGGGGGTCCTCAGG	0.572000													6	15					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43400228	43400228	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43400228C>T	ENST00000244533.3	+	1	740	c.381C>T	c.(379-381)gcC>gcT	p.A127A	ABCC10_ENST00000372530.4_Silent_p.A170A|ABCC10_ENST00000443426.2_Intron	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	170						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCCATGGCCCGCCTATGCT	0.652000													42	80					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41585482	41585482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41585482C>T	ENST00000396942.1	-	4	354	c.271G>A	c.(271-273)Gat>Aat	p.D91N	ANK1_ENST00000352337.4_Missense_Mutation_p.D91N|ANK1_ENST00000396945.1_Missense_Mutation_p.D91N|ANK1_ENST00000289734.7_Missense_Mutation_p.D91N|ANK1_ENST00000379758.2_Missense_Mutation_p.D91N|ANK1_ENST00000265709.8_Missense_Mutation_p.D124N|ANK1_ENST00000347528.4_Missense_Mutation_p.D91N			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	91	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACCACCTCATCCTGCCCGGCT	0.602000													13	65					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142626169	142626169	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142626169G>A	ENST00000265310.1	-	5	882	c.534C>T	c.(532-534)atC>atT	p.I178I	TRPV5_ENST00000442623.1_Silent_p.I178I	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	178					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCAGCCGCACGATCTCCTCGC	0.617000													10	31					0	0	1	0	0
FRMD3	257019	broad.mit.edu	37	9	85863064	85863064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:85863064C>T	ENST00000304195.3	-	14	1769	c.1563G>A	c.(1561-1563)gtG>gtA	p.V521V	FRMD3_ENST00000376434.1_Silent_p.V327V|FRMD3_ENST00000465485.1_5'UTR|FRMD3_ENST00000376438.1_Silent_p.V521V|FRMD3_ENST00000328788.1_Silent_p.V178V	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	521						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						CCAGTGGGTTCACCCGAATAT	0.517000													26	58					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45361850	45361850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45361850G>A	ENST00000559488.1	+	4	419	c.403G>A	c.(403-405)Gat>Aat	p.D135N	ITGB3_ENST00000435993.2_Missense_Mutation_p.D88N|ITGB3_ENST00000571680.1_Missense_Mutation_p.D135N|ITGB3_ENST00000560629.1_Missense_Mutation_p.G123E	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	135	VWFA.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	GCAGGTGGAGGATTACCCTGT	0.468000													16	37					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27455991	27455991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27455991G>A	ENST00000337929.3	+	6	1109	c.636G>A	c.(634-636)ggG>ggA	p.G212G	IL21R_ENST00000564583.1_3'UTR|IL21R_ENST00000395754.4_Silent_p.G212G|IL21R_ENST00000564089.1_Silent_p.G212G|IL21R_ENST00000395755.1_Silent_p.G212G	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	212					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						CCTACCAGGGGACCTGGAGTG	0.582000			T	BCL6	NHL								19	86					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814171	60814171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60814171G>A	ENST00000544856.2	-	7	1433	c.1055C>T	c.(1054-1056)tCa>tTa	p.S352L	RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.S353L|MARCH10_ENST00000311269.5_Missense_Mutation_p.S353L|MARCH10_ENST00000583600.1_Missense_Mutation_p.S391L|RP11-156L14.1_ENST00000582564.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	353							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						TATTCTCAATGAGCCATGACT	0.493000													50	108					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38445684	38445684	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38445684G>A	ENST00000397210.3	+	0	43				EGFLAM_ENST00000506135.1_De_novo_Start_InFrame|EGFLAM_ENST00000397202.2_Intron|EGFLAM_ENST00000322350.5_Intron|EGFLAM_ENST00000336740.6_Intron|EGFLAM_ENST00000354891.3_Intron	NM_182801.2	NP_877953.1	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains							cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GAGAAACAAGGCTGGCTTCAA	0.522000													22	57					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046780	73046780	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73046780C>T	ENST00000604411.1	+	0	34741				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CCAACTCAGGCCTTCGGTCCA	0.493000													27	23					0	0	1	0	0
RPRD1B	58490	broad.mit.edu	37	20	36676878	36676878	+	Missense_Mutation	SNP	C	C	T	rs140300358		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36676878C>T	ENST00000373433.4	+	3	812	c.410C>T	c.(409-411)cCc>cTc	p.P137L		NM_021215.3	NP_067038.1	Q9NQG5	RPR1B_HUMAN	regulation of nuclear pre-mRNA domain containing 1B	137										endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)	12						AGCCCTCCCCCCAAAGGTAGA	0.478000													16	64					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7846791	7846791	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7846791G>A	ENST00000328375.1	-	1	728	c.729C>T	c.(727-729)tcC>tcT	p.S243S	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAGTGAGGTGGGAGGTGCAGG	0.507000													23	88					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323636	79323636	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79323636A>T	ENST00000428286.1	-	8	3677	c.2477T>A	c.(2476-2478)gTa>gAa	p.V826E	PRUNE2_ENST00000376718.3_Missense_Mutation_p.V1185E			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1185					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CTCCCAATCTACCTGATTTGC	0.498000													19	68					0	0	1	0	0
TRBV2	28620	broad.mit.edu	37	7	142001208	142001208	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142001208C>T	ENST00000455382.2	+	0	374																											AGATCCGGTCCACAAAGCTGG	0.453000													6	26					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120996131	120996131	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120996131C>T	ENST00000392793.1	+	8	1595	c.1324C>T	c.(1324-1326)Cag>Tag	p.Q442*	TECTA_ENST00000264037.2_Nonsense_Mutation_p.Q442*			O75443	TECTA_HUMAN	tectorin alpha	442	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TTTTGATGGCCAGCACTACGC	0.483000													91	390					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17657537	17657537	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17657537C>T	ENST00000375448.4	+	2	192	c.166C>T	c.(166-168)Cct>Tct	p.P56S	PADI4_ENST00000375453.1_Missense_Mutation_p.P56S|AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	56					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	TGCCCACGGCCCTCCAGCCAA	0.602000													23	44					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127505	152127505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152127505C>T	ENST00000316073.3	-	3	2134	c.2070G>A	c.(2068-2070)caG>caA	p.Q690Q		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	690	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TGGTCTGGGCCTGTCTGTGGC	0.527000													61	160					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389325	1389325	+	Silent	SNP	C	C	T	rs71299249		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1389325C>T	ENST00000324803.4	+	1	3986	c.1026C>T	c.(1024-1026)gcC>gcT	p.A342A		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	342					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GAGTGCCCGCCTGCTCACACG	0.667000													31	345					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20344970	20344970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20344970C>T	ENST00000298642.2	+	1	580	c.544C>T	c.(544-546)Cct>Tct	p.P182S		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGTGACCTTCCTGTGGTGTT	0.423000													134	315					0	0	1	0	0
TDP2	51567	broad.mit.edu	37	6	24667042	24667042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24667042C>T	ENST00000378198.4	-	1	219	c.49G>A	c.(49-51)Gag>Aag	p.E17K	TDP2_ENST00000545995.1_Missense_Mutation_p.E47K			O95551	TYDP2_HUMAN	tyrosyl-DNA phosphodiesterase 2	17					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			kidney(2)|large_intestine(1)|lung(5)|ovary(1)	9						GGCTCGCCCTCTTCCTCCGCC	0.647000								Direct reversal of damage					106	242					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144874791	144874791	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:144874791G>A	ENST00000369359.4	-	33	5263	c.5225C>T	c.(5224-5226)tCt>tTt	p.S1742F	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S1606F|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S1606F|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S1562F|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S1742F			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1606			A -> S (in dbSNP:rs1698605).		cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTGCTGGGAGAGCGGTGGGA	0.547000			T	PDGFRB	MPD								29	328					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045324	142045324	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142045324G>A	ENST00000390392.3	+	0	73																											TCACCCAGAGGACCCCAGTCA	0.602000													20	84					0	0	1	0	0
NRP1	8829	broad.mit.edu	37	10	33559689	33559689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:33559689G>A	ENST00000265371.4	-	4	869	c.344C>T	c.(343-345)tCa>tTa	p.S115L	NRP1_ENST00000374821.5_Missense_Mutation_p.S115L|NRP1_ENST00000374823.5_Missense_Mutation_p.S115L|NRP1_ENST00000374867.2_Missense_Mutation_p.S115L|NRP1_ENST00000395995.1_Missense_Mutation_p.S115L|NRP1_ENST00000374822.4_Missense_Mutation_p.S115L|NRP1_ENST00000374816.3_Missense_Mutation_p.S115L			O14786	NRP1_HUMAN	neuropilin 1	115	CUB 1.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	AAATGGCCCTGAAGACACAAC	0.403000													24	64					0	0	1	0	0
INTS6	26512	broad.mit.edu	37	13	51943380	51943380	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:51943380G>A	ENST00000311234.4	-	16	2643	c.2171C>T	c.(2170-2172)tCa>tTa	p.S724L	INTS6_ENST00000490542.1_Missense_Mutation_p.S408L|INTS6_ENST00000463928.1_3'UTR|INTS6_ENST00000497989.1_Missense_Mutation_p.S546L|INTS6_ENST00000425000.1_Missense_Mutation_p.S292L|INTS6_ENST00000398119.2_Missense_Mutation_p.S711L	NM_012141.2	NP_036273.1	Q9UL03	INT6_HUMAN	integrator complex subunit 6	724					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity	p.S724L(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		AATGTCTGATGAAAGTTGGTC	0.388000													9	64					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85981972	85981972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85981972C>T	ENST00000372113.4	-	3	1362	c.1357G>A	c.(1357-1359)Gat>Aat	p.D453N	LRIT2_ENST00000538192.1_Missense_Mutation_p.D463N	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	453						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						CCACCAGCATCTCTGCCTGTT	0.597000													35	94					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73485203	73485203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73485203G>A	ENST00000224721.6	+	29	3525	c.3520G>A	c.(3520-3522)Gag>Aag	p.E1174K	C10orf105_ENST00000398786.2_Intron	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1169	Cadherin 11.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CCTGGACCGGGAGCGGAACTC	0.657000													10	32					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103249038	103249038	+	Silent	SNP	C	C	T	rs62508587		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:103249038C>T	ENST00000553106.1	-	6	1054	c.582G>A	c.(580-582)ctG>ctA	p.L194L	PAH_ENST00000307000.2_Silent_p.L189L	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	194			L -> P (in PKU).|Missing (in PKU).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	ACAAGGACTTCAGAGTCTTGA	0.438000													12	57					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47571890	47571890	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47571890C>T	ENST00000334194.3	+	9	1161	c.1158C>T	c.(1156-1158)ctC>ctT	p.L386L	CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	386						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						CCCGGTTACTCGACAAACCCA	0.463000													10	126					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117996324	117996324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117996324G>A	ENST00000425217.1	-	8	1347	c.1293C>T	c.(1291-1293)atC>atT	p.I431I	KSR2_ENST00000302438.5_Silent_p.I157I|KSR2_ENST00000339824.5_Silent_p.I460I|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	460					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCGGTGGATGATCAGAAGAT	0.507000													9	61					0	0	1	0	0
CCM2	83605	broad.mit.edu	37	7	45108060	45108060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:45108060C>T	ENST00000381112.3	+	5	1233	c.554C>T	c.(553-555)tCc>tTc	p.S185F	CCM2_ENST00000474617.1_Intron|CCM2_ENST00000541586.1_Missense_Mutation_p.S106F|CCM2_ENST00000461377.1_3'UTR|CCM2_ENST00000544363.1_Intron|CCM2_ENST00000258781.6_Missense_Mutation_p.S164F|CCM2_ENST00000475551.1_Missense_Mutation_p.S158F	NM_001029835.2	NP_001025006.1	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2	164	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding			NS(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						CCAGGGATCTCCCCCAGCCAG	0.612000													33	63					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61988009	61988009	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:61988009C>T	ENST00000409186.1	-	5	2328	c.223G>A	c.(223-225)Gga>Aga	p.G75R	PCDH20_ENST00000409204.4_Missense_Mutation_p.G75R			Q8N6Y1	PCD20_HUMAN	protocadherin 20	48	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GCGGGTAGTCCCTCGTTTAGG	0.652000													4	20					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68747555	68747555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68747555G>A	ENST00000309106.3	-	1	900	c.901C>T	c.(901-903)Cgc>Tgc	p.R301C		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	301						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGCTCCTCGCGAAGCGCCTGT	0.677000													35	65					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113496541	113496541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113496541G>A	ENST00000416899.2	+	6	765	c.639G>A	c.(637-639)agG>agA	p.R213R	MUSK_ENST00000189978.5_Silent_p.R213R|MUSK_ENST00000374448.4_Silent_p.R213R			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	213	Ig-like 3.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						TTTTTGCCAGGATCCTGCGGG	0.502000													5	21					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9983625	9983625	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:9983625T>C	ENST00000256190.8	-	16	1876	c.1739A>G	c.(1738-1740)aAa>aGa	p.K580R		NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	580					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TGCCTTTCCTTTAAGGGCTCT	0.448000													28	62					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36623931	36623931	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:36623931G>A	ENST00000280527.2	+	2	872		c.e2+1			NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)						nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				AGAATTGAAGGTAAGCATTAA	0.373000													22	96					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153149829	153149829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153149829G>A	ENST00000285900.5	+	13	2467	c.2124G>A	c.(2122-2124)agG>agA	p.R708R	GRIA1_ENST00000518783.1_Silent_p.R718R|GRIA1_ENST00000521843.2_Silent_p.R639R|GRIA1_ENST00000340592.5_Silent_p.R708R|GRIA1_ENST00000448073.4_Silent_p.R718R|GRIA1_ENST00000518142.1_Silent_p.R628R	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	708					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTCGAGTGAGGAAATCCAAAG	0.483000													22	59					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16475030	16475030	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16475030G>A	ENST00000358432.5	-	3	820	c.666C>T	c.(664-666)tcC>tcT	p.S222S	EPHA2_ENST00000461614.1_5'UTR	NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	222	Cys-rich.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CAGTGGCCAGGGAAGGTGCAT	0.662000													7	55					0	0	1	0	0
USP49	25862	broad.mit.edu	37	6	41774051	41774051	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41774051G>A	ENST00000394253.3	-	3	1000	c.671C>T	c.(670-672)tCg>tTg	p.S224L	USP49_ENST00000373006.1_Missense_Mutation_p.S224L|USP49_ENST00000373009.3_Missense_Mutation_p.S224L|USP49_ENST00000373010.1_Missense_Mutation_p.S224L|USP49_ENST00000297229.2_Missense_Mutation_p.S224L			Q70CQ1	UBP49_HUMAN	ubiquitin specific peptidase 49	224					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(2)|skin(2)	23	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ggcggggcgcgaggcagccgg	0.751000													16	16					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12203184	12203184	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12203184C>T	ENST00000432424.2	+	0	1009							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TTGTGAACTGCTATTCTCCCT	0.507000													9	14					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157669500	157669500	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157669500G>A	ENST00000368184.3	-	3	325	c.34C>T	c.(34-36)Cct>Tct	p.P12S	FCRL3_ENST00000368186.5_Missense_Mutation_p.P12S	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	12						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					TCTCTTCCAGGAGCTGTGAGG	0.468000													11	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179501469	179501469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179501469C>T	ENST00000589042.1	-	225	41209	c.40985G>A	c.(40984-40986)gGa>gAa	p.G13662E	TTN-AS1_ENST00000418062.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G11094E|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G4597E|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G4789E|TTN_ENST00000359218.5_Missense_Mutation_p.G4722E|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G12021E|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12021	Ig-like 93.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCACCACTTCCTGGCCTTAA	0.423000													24	57					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153056708	153056708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153056708G>A	ENST00000285900.5	+	7	1359	c.1016G>A	c.(1015-1017)aGa>aAa	p.R339K	GRIA1_ENST00000518783.1_Missense_Mutation_p.R349K|GRIA1_ENST00000521843.2_Missense_Mutation_p.R270K|GRIA1_ENST00000340592.5_Missense_Mutation_p.R339K|GRIA1_ENST00000448073.4_Missense_Mutation_p.R349K|GRIA1_ENST00000518142.1_Missense_Mutation_p.R259K	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	339					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GACATCCAGAGAGCTCTGCAG	0.517000													10	36					0	0	1	0	0
CUEDC1	404093	broad.mit.edu	37	17	55962752	55962752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:55962752G>A	ENST00000577830.1	-	2	587	c.174C>T	c.(172-174)ttC>ttT	p.F58F	CUEDC1_ENST00000577840.1_Intron|CUEDC1_ENST00000407144.2_Silent_p.F58F|CUEDC1_ENST00000360238.2_Silent_p.F58F	NM_001271875.1	NP_001258804.1	Q9NWM3	CUED1_HUMAN	CUE domain containing 1	58	CUE.									endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12						CCATGTTGGGGAACATGGTCT	0.647000													33	55					0	0	1	0	0
KLRC3	3823	broad.mit.edu	37	12	10569274	10569274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10569274G>A	ENST00000396439.2	-	5	623	c.579C>T	c.(577-579)ttC>ttT	p.F193F	NKG2-E_ENST00000539033.1_Silent_p.F193F|KLRC3_ENST00000381903.2_Silent_p.F193F|KLRC3_ENST00000381904.2_Silent_p.F193F	NM_002261.2	NP_002252.2			killer cell lectin-like receptor subfamily C, member 3											large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						ACTCATGTTTGAAAGCCAAAC	0.318000													16	77					0	0	1	0	0
OR5T1	390155	broad.mit.edu	37	11	56043528	56043528	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56043528C>T	ENST00000313033.2	+	1	500	c.414C>T	c.(412-414)atC>atT	p.I138I		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					ATGTAGCCATCTACAACCCTC	0.428000													97	184					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92734558	92734558	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92734558G>A	ENST00000379958.2	-	3	1122	c.853C>T	c.(853-855)Cga>Tga	p.R285*		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	285						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTTGGCTCTCGAATGCACTTC	0.373000													36	92					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103400012	103400012	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103400012C>A	ENST00000358392.2	-	46	3946	c.3629G>T	c.(3628-3630)gGt>gTt	p.G1210V	COL11A1_ENST00000370096.3_Missense_Mutation_p.G1198V|COL11A1_ENST00000512756.1_Missense_Mutation_p.G1082V|COL11A1_ENST00000353414.4_Missense_Mutation_p.G1159V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1198	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TACCTGAAGACCTATTGGACC	0.458000													15	70					4.14922e-12	4.16852e-12	1	1	0
PCLO	27445	broad.mit.edu	37	7	82545094	82545094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82545094C>T	ENST00000423517.2	-	7	12545	c.12208G>A	c.(12208-12210)Gaa>Aaa	p.E4070K	PCLO_ENST00000333891.8_Missense_Mutation_p.E4070K|PCLO_ENST00000437081.1_Missense_Mutation_p.E790K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4001					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGATCCTTTTCATGAAGGCTA	0.448000													3	17					0	0	1	0	0
SKAP2	8935	broad.mit.edu	37	7	26778453	26778453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:26778453G>A	ENST00000345317.2	-	6	743	c.430C>T	c.(430-432)Ctc>Ttc	p.L144F	SKAP2_ENST00000489977.1_5'UTR|SKAP2_ENST00000539623.1_5'UTR	NM_003930.3	NP_003921.2	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	144	PH.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(3)	17						GTTTTACTGAGAGCACACCAC	0.363000													42	75					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237037098	237037098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237037098C>T	ENST00000366577.5	+	23	2825	c.2431C>T	c.(2431-2433)Cca>Tca	p.P811S	MTR_ENST00000535889.1_Missense_Mutation_p.P760S	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	811	B12-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGTCATGACTCCATGTGATAA	0.378000													27	85					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96962966	96962966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:96962966C>T	ENST00000389672.5	+	5	1479	c.1441C>T	c.(1441-1443)Cgc>Tgc	p.R481C	EPHA6_ENST00000470610.2_Missense_Mutation_p.R481C	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	386	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TGGAGGACTCCGCTTCATCCC	0.448000													19	46					0	0	1	0	0
CIB2	10518	broad.mit.edu	37	15	78401619	78401619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78401619C>T	ENST00000258930.3	-	4	632	c.304G>A	c.(304-306)Gct>Act	p.A102T	CIB2_ENST00000560618.1_Missense_Mutation_p.A59T|CIB2_ENST00000539011.1_Missense_Mutation_p.A59T|CIB2_ENST00000557846.1_Missense_Mutation_p.A53T	NM_006383.2	NP_006374.1	O75838	CIB2_HUMAN	calcium and integrin binding family member 2	102							calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	11						TCTCGGGGAGCCGACTCGCAG	0.552000													25	75					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38523620	38523620	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38523620G>A	ENST00000263409.4	-	5	624	c.462C>T	c.(460-462)taC>taT	p.Y154Y	LIFR_ENST00000453190.2_Silent_p.Y154Y|LIFR_ENST00000503088.1_5'UTR	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	154					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TCCACTTTAGGTATAATGTAG	0.363000			T	PLAG1	salivary adenoma								14	79					0	0	1	0	0
ZNF512	84450	broad.mit.edu	37	2	27838116	27838116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27838116C>T	ENST00000355467.4	+	11	1296	c.1213C>T	c.(1213-1215)Cgt>Tgt	p.R405C	ZNF512_ENST00000556601.1_Missense_Mutation_p.R274C|ZNF512_ENST00000379717.1_Missense_Mutation_p.R404C|ZNF512_ENST00000416005.2_Missense_Mutation_p.R376C|RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000413371.2_Missense_Mutation_p.R328C			Q96ME7	ZN512_HUMAN	zinc finger protein 512	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					GAAATATCATCGTATTCAGTG	0.373000													38	153					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101720918	101720918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101720918C>T	ENST00000261637.4	+	26	3275	c.3101C>T	c.(3100-3102)tCa>tTa	p.S1034L		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1034					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						AAATCTGCTTCAGGCACCCGC	0.463000													38	101					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86697752	86697752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86697752C>T	ENST00000441037.2	+	3	311	c.216C>T	c.(214-216)ctC>ctT	p.L72L	AGBL1_ENST00000421325.2_Silent_p.L72L	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	72					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						GCCAGAATCTCCTCCACTGTC	0.507000													20	22					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76957805	76957805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:76957805C>T	ENST00000380887.2	+	6	875	c.803C>T	c.(802-804)tCc>tTc	p.S268F	ESRRB_ENST00000261532.7_Missense_Mutation_p.S268F|ESRRB_ENST00000509242.1_Missense_Mutation_p.S268F|ESRRB_ENST00000556177.1_Missense_Mutation_p.S268F			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	268						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		TCAAGCCTCTCCCTGGGGGAC	0.647000													3	10					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89531571	89531571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:89531571C>T	ENST00000329758.1	-	8	1414	c.1086G>A	c.(1084-1086)cgG>cgA	p.R362R	TRIM49_ENST00000532501.2_Silent_p.R285R	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	362	B30.2/SPRY.					intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TCTTCTCTTTCCGATACATAT	0.453000													42	146					0	0	1	0	0
EFNB1	1947	broad.mit.edu	37	X	68060237	68060237	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:68060237C>T	ENST00000204961.4	+	5	1561	c.781C>T	c.(781-783)Cta>Tta	p.L261L		NM_004429.4	NP_004420.1	P98172	EFNB1_HUMAN	ephrin-B1	261					cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	22						CCTGACGGTCCTACTACTGAA	0.622000													12	11					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873178	55873178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55873178C>T	ENST00000313503.1	+	1	660	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					CCTATGTGTTCATTCTCTTTA	0.403000										HNSCC(53;0.14)			55	124					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188228210	188228210	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:188228210T>A	ENST00000409998.1	-	10	1301	c.520A>T	c.(520-522)Att>Ttt	p.I174F	CALCRL_ENST00000392370.3_Missense_Mutation_p.I174F|AC007319.1_ENST00000412276.1_RNA|CALCRL_ENST00000410068.1_Missense_Mutation_p.I174F|AC007319.1_ENST00000453517.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	174						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TGTAAGGTAATCCTTTGGCAA	0.353000													20	81					0	0	1	0	0
BCHE	590	broad.mit.edu	37	3	165503967	165503967	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:165503967C>T	ENST00000264381.3	-	3	1816	c.1650G>A	c.(1648-1650)tgG>tgA	p.W550*	BCHE_ENST00000540653.1_Nonsense_Mutation_p.W12*	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	550					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAAATGATGTCCAGAATCGAC	0.353000													10	67					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28848076	28848076	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28848076C>T	ENST00000340394.8	+	23	3325	c.3113C>T	c.(3112-3114)cCc>cTc	p.P1038L	ATXN2L_ENST00000395547.2_3'UTR|ATXN2L_ENST00000336783.4_3'UTR|ATXN2L_ENST00000325215.6_Silent_p.P1048P|ATXN2L_ENST00000570200.1_Missense_Mutation_p.P1056L|RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000564304.1_Missense_Mutation_p.P1062L|ATXN2L_ENST00000382686.4_Silent_p.P1030P	NM_148415.2|NM_148416.2	NP_680781.1|NP_680782.1	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	1036						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						CAGCAGCTCCCCTTCCACCCC	0.582000													14	61					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186015231	186015231	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186015231C>T	ENST00000265022.3	-	5	891	c.352G>A	c.(352-354)Gag>Aag	p.E118K	DGKG_ENST00000382164.4_Missense_Mutation_p.E118K|DGKG_ENST00000344484.4_Missense_Mutation_p.E118K|DGKG_ENST00000544847.1_Missense_Mutation_p.E118K	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	118					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	GCACAGGCCTCGTCTGCTTTG	0.448000													21	106					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56390337	56390337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:56390337G>A	ENST00000423270.1	-	8	1048	c.1049C>T	c.(1048-1050)tCa>tTa	p.S350L	RFX7_ENST00000317318.6_Missense_Mutation_p.S350L|RFX7_ENST00000422057.1_Missense_Mutation_p.S253L|RFX7_ENST00000559447.2_Missense_Mutation_p.S253L	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	253					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						AGAAAGGATTGAAGGATTTCC	0.423000													21	46					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42566673	42566673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42566673G>A	ENST00000262895.3	-	4	474	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S	GRIK5_ENST00000593562.1_Missense_Mutation_p.P159S|GRIK5_ENST00000301218.4_Missense_Mutation_p.P159S	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	159						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CTGGCCGAGGGGTAGTTGAAG	0.572000													33	54					0	0	1	0	0
NKG7	4818	broad.mit.edu	37	19	51875290	51875290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51875290C>T	ENST00000221978.5	-	3	522	c.343G>A	c.(343-345)Gag>Aag	p.E115K	NKG7_ENST00000600427.1_Intron|NKG7_ENST00000595217.1_Silent_p.A108A	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	115						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TCCCACCGCTCGCTGGTGTAC	0.607000													29	67					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	69640520	69640520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:69640520C>T	ENST00000370598.1	+	4	1648	c.827C>T	c.(826-828)cCt>cTt	p.P276L		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	276					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				AAAAGGGTCCCTCAGGAACAA	0.343000													8	49					0	0	1	0	0
RNF38	152006	broad.mit.edu	37	9	36352839	36352839	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:36352839G>A	ENST00000357058.3	-	8	1435	c.829C>T	c.(829-831)Cct>Tct	p.P277S	RNF38_ENST00000259605.6_Missense_Mutation_p.P360S|RNF38_ENST00000377877.4_Missense_Mutation_p.P284S|RNF38_ENST00000350199.4_Missense_Mutation_p.P277S|RNF38_ENST00000353739.4_Missense_Mutation_p.P310S|RNF38_ENST00000377885.2_Missense_Mutation_p.P277S	NM_194328.2	NP_919309.1	Q9H0F5	RNF38_HUMAN	ring finger protein 38	360	Pro-rich.						zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			ATAAATGGAGGATAAGGCTGC	0.403000													5	31					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103155868	103155868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103155868G>A	ENST00000424685.2	-	50	8042	c.7883C>T	c.(7882-7884)cCt>cTt	p.P2628L	RELN_ENST00000343529.5_Missense_Mutation_p.P2628L|RELN_ENST00000428762.1_Missense_Mutation_p.P2628L			P78509	RELN_HUMAN	reelin	2628					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGCATCAGGAGGGAGAAGGAT	0.478000													15	36					0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978659	10978659	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10978659G>A	ENST00000240619.2	-	1	298	c.210C>T	c.(208-210)ttC>ttT	p.F70F		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	70					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						TATTTGGAGAGAATATCTGTA	0.333000													18	44					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3831551	3831551	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3831551C>T	ENST00000309890.7	-	21	3201	c.3051G>A	c.(3049-3051)tgG>tgA	p.W1017*	ATP2A3_ENST00000359983.3_Nonsense_Mutation_p.W1017*|ATP2A3_ENST00000352011.3_Nonsense_Mutation_p.W1017*|ATP2A3_ENST00000397041.3_Intron|ATP2A3_ENST00000397035.3_Nonsense_Mutation_p.W1017*|ATP2A3_ENST00000397039.1_Intron|ATP2A3_ENST00000397043.3_Intron	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	1017					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GGTCTGGGGTCCAAGAGGTGG	0.612000													16	32					0	0	1	0	0
TSPAN12	23554	broad.mit.edu	37	7	120428761	120428761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120428761G>A	ENST00000222747.3	-	8	1410	c.803C>T	c.(802-804)tCt>tTt	p.S268F	TSPAN12_ENST00000415871.1_Missense_Mutation_p.S268F	NM_012338.3	NP_036470.1	O95859	TSN12_HUMAN	tetraspanin 12	268					angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction				endometrium(3)|kidney(1)|lung(4)|ovary(1)|skin(1)	10	all_neural(327;0.117)					CAGGTGCTGAGAGTTGTCATT	0.453000													56	112					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130932542	130932542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130932542G>A	ENST00000409031.1	-	3	1336	c.188C>T	c.(187-189)cCc>cTc	p.P63L	SMPD4_ENST00000453750.1_Missense_Mutation_p.P63L|SMPD4_ENST00000431183.2_Missense_Mutation_p.P63L|SMPD4_ENST00000452225.2_Intron|SMPD4_ENST00000339679.7_5'UTR|SMPD4_ENST00000351288.6_Missense_Mutation_p.P63L|SMPD4_ENST00000473720.1_Intron|SMPD4_ENST00000426662.2_Intron|SMPD4_ENST00000443958.2_Intron	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	24					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CTGTGCAAAGGGCTTATTTAT	0.443000													41	105					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306651	41306651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:41306651C>T	ENST00000373198.3	-	7	1243	c.1008G>A	c.(1006-1008)gaG>gaA	p.E336E	PTPRT_ENST00000373193.3_Silent_p.E336E|PTPRT_ENST00000373184.1_Silent_p.E336E|PTPRT_ENST00000373201.1_Silent_p.E336E|PTPRT_ENST00000373190.1_Silent_p.E336E|PTPRT_ENST00000373187.1_Silent_p.E336E|PTPRT_ENST00000356100.2_Silent_p.E336E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	336	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTATGTGGGTCTCTGCCCACG	0.552000													41	92					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42437980	42437980	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42437980C>T	ENST00000397272.3	-	15	1753	c.1662G>A	c.(1660-1662)cgG>cgA	p.R554R	PLA2G4F_ENST00000382396.4_Silent_p.R552R	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	552	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GGTAACAGATCCGGGGTTCAG	0.632000													9	63					0	0	1	0	0
ATG16L1	55054	broad.mit.edu	37	2	234200864	234200864	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234200864C>T	ENST00000392017.4	+	15	1778	c.1521C>T	c.(1519-1521)tcC>tcT	p.S507S	ATG16L1_ENST00000347464.5_Silent_p.S344S|ATG16L1_ENST00000392020.4_Silent_p.S488S|ATG16L1_ENST00000392018.1_Silent_p.S524S|ATG16L1_ENST00000373525.5_Silent_p.S328S	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	507					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		TGAGCTGCTCCCGTGATGACT	0.473000													17	60					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902119	51902119	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:51902119C>T	ENST00000268919.4	+	1	1881	c.1725C>T	c.(1723-1725)tcC>tcT	p.S575S		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	575					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CAGAAATGTCCCTTCAGAGGG	0.403000													20	71					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53208027	53208027	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53208027C>T	ENST00000293774.4	-	1	308	c.38G>A	c.(37-39)gGg>gAg	p.G13E	KRT4_ENST00000551956.1_5'UTR			B4DRS2	B4DRS2_HUMAN	keratin 4	0						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CTTCCCGCACCCGTTGAGCAT	0.537000													22	49					0	0	1	0	0
TRGC2	6967	broad.mit.edu	37	7	38289092	38289092	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38289092C>T	ENST00000436911.2	-	0	81																											AAGGTATGTTCCAGCCTTCTG	0.403000													101	238					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102464199	102464199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102464199G>A	ENST00000260228.2	-	8	1230	c.1218C>T	c.(1216-1218)acC>acT	p.T406T		NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	406	Hemopexin-like 3.				proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CAAAGAAAAGGGTCTTCTGTG	0.388000													41	54					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102992208	102992208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102992208C>T	ENST00000375735.2	+	10	1612	c.1468C>T	c.(1468-1470)Cgc>Tgc	p.R490C	DYNC2H1_ENST00000334267.7_Missense_Mutation_p.R490C|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.R490C	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	490	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AGTTTGGGTTCGCCAGTTGGA	0.368000													22	61					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42833145	42833145	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42833145C>T	ENST00000314073.5	+	13	3377	c.3201C>T	c.(3199-3201)tcC>tcT	p.S1067S	GLTSCR1L_ENST00000394168.1_Silent_p.S1067S					GLTSCR1-like																		AAACTGACTCCATTTTAGAAG	0.512000													45	115					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475910	120475910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:120475910G>A	ENST00000355622.6	+	3	1605	c.1504G>A	c.(1504-1506)Gac>Aac	p.D502N	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.D462N	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	502					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GACCTTCCTGGACCTCTCTCA	0.438000													27	54					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119731983	119731983	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:119731983G>A	ENST00000541757.1	+	6	681	c.301G>A	c.(301-303)Gcc>Acc	p.A101T	MARCO_ENST00000327097.4_Missense_Mutation_p.A179T			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	179					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						TGAGAAGGGAGCCAAGGGGGC	0.562000													5	13					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23410955	23410955	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23410955C>T	ENST00000379361.4	+	3	2180	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	440					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						ATAGTATCTTCTGTAGAAAAG	0.468000													60	29					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102483436	102483436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:102483436C>T	ENST00000369138.1	+	14	2796	c.2306C>T	c.(2305-2307)cCc>cTc	p.P769L	GRIK2_ENST00000369137.3_Missense_Mutation_p.P693L|GRIK2_ENST00000413795.1_Missense_Mutation_p.P769L|GRIK2_ENST00000318991.6_Missense_Mutation_p.P769L|GRIK2_ENST00000369134.4_Missense_Mutation_p.P720L|GRIK2_ENST00000421544.1_Missense_Mutation_p.P769L	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	769					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GTTGGCACTCCCATGGGTAGG	0.438000													47	67					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48683440	48683440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48683440G>A	ENST00000416767.4	+	23	4506	c.4478G>A	c.(4477-4479)gGg>gAg	p.G1493E	CACNA1G_ENST00000512389.1_Intron|CACNA1G_ENST00000507336.1_Intron|CACNA1G_ENST00000507609.1_Intron|CACNA1G_ENST00000354983.4_Intron|CACNA1G_ENST00000503485.1_Intron|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000510115.1_Intron|CACNA1G_ENST00000352832.5_Intron|CACNA1G_ENST00000510366.1_Intron|CACNA1G_ENST00000502264.1_Intron|CACNA1G_ENST00000429973.2_Intron|CACNA1G_ENST00000360761.4_Intron|CACNA1G_ENST00000515765.1_Intron|CACNA1G_ENST00000515411.1_Intron|CACNA1G_ENST00000442258.2_Intron|CACNA1G_ENST00000515165.1_Intron|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000359106.5_Intron|CACNA1G_ENST00000514717.1_Intron|CACNA1G_ENST00000514181.1_Intron|CACNA1G_ENST00000514079.1_Intron|CACNA1G_ENST00000513964.1_Intron|CACNA1G_ENST00000507510.2_Intron|CACNA1G_ENST00000513689.2_Intron			O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	982					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGGGGCACAGGGCCATGCTTA	0.602000													31	49					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87179256	87179256	+	Missense_Mutation	SNP	G	G	A	rs142600685	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87179256G>A	ENST00000265724.3	-	14	1882	c.1465C>T	c.(1465-1467)Cgc>Tgc	p.R489C	ABCB1_ENST00000543898.1_Missense_Mutation_p.R425C	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	489	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CGGCCATAGCGAATGTTTTCA	0.428000													29	225					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424299	56424299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56424299G>A	ENST00000588751.1	-	5	908	c.884C>T	c.(883-885)cCc>cTc	p.P295L	NLRP13_ENST00000342929.3_Missense_Mutation_p.P295L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	295	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CTCTTCAATGGGGGCATCAAA	0.398000													26	66					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15053254	15053254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15053254C>T	ENST00000248072.3	+	1	954	c.954C>T	c.(952-954)ctC>ctT	p.L318L		NM_012377.1	NP_036509.1	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C, member 2	318					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(8)|ovary(2)|skin(2)	15	Ovarian(108;0.203)					TTGCTAAGCTCTCATGAATTG	0.478000													28	52					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66479913	66479913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:66479913C>T	ENST00000256447.4	-	3	915	c.758G>A	c.(757-759)gGa>gAa	p.G253E		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	253					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		CTCAAATGTTCCCAGCCAGAG	0.438000													26	60					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51696586	51696586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51696586G>A	ENST00000335449.6	+	10	1347	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K	GLDN_ENST00000396399.2_Missense_Mutation_p.E307K	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	431	Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		AGCTGTAGATGAAAAGGGCCT	0.418000													60	153					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100657	93100657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:93100657C>T	ENST00000544406.2	+	2	516	c.250C>T	c.(250-252)Ctt>Ttt	p.L84F	C12orf74_ENST00000397833.3_Missense_Mutation_p.L84F			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	84										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						CCCATGTTACCTTTCGAAGAG	0.557000													22	48					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50058997	50058997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50058997G>A	ENST00000281631.5	+	7	597	c.439G>A	c.(439-441)Gaa>Aaa	p.E147K	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505697.2_Missense_Mutation_p.E147K|PARP8_ENST00000503750.2_Missense_Mutation_p.E147K|PARP8_ENST00000505554.1_Missense_Mutation_p.E126K|PARP8_ENST00000514067.2_Missense_Mutation_p.E147K|PARP8_ENST00000514342.2_5'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	147						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				CTATGATGGGGAACTGCACAA	0.418000													11	40					0	0	1	0	0
FAM181A	90050	broad.mit.edu	37	14	94394620	94394620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94394620G>A	ENST00000267594.5	+	3	482	c.175G>A	c.(175-177)Ggc>Agc	p.G59S	FAM181A_ENST00000557719.1_5'UTR|FAM181A_ENST00000557000.2_5'UTR|FAM181A_ENST00000556222.1_5'UTR	NM_001207073.1|NM_001207074.1|NM_138344.4	NP_001194002.1|NP_001194003.1|NP_612353.3	Q8N9Y4	F181A_HUMAN	family with sequence similarity 181, member A	59										cervix(1)|endometrium(2)|large_intestine(8)|lung(4)|prostate(1)|skin(2)	18						CTCGTGCAGTGGCCCCCTGGT	0.607000													26	56					0	0	1	0	0
EDDM3B	64184	broad.mit.edu	37	14	21238538	21238538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21238538G>A	ENST00000326783.3	+	2	327	c.229G>A	c.(229-231)Gag>Aag	p.E77K		NM_022360.4	NP_071755.1	P56851	EP3B_HUMAN	epididymal protein 3B	77					spermatid development	extracellular region				central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						GTACAAAATCGAGCATATATG	0.403000													25	71					0	0	1	0	0
DENND4C	55667	broad.mit.edu	37	9	19350783	19350783	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:19350783C>T	ENST00000307015.9	+	20	3717	c.1965C>T	c.(1963-1965)atC>atT	p.I655I	DENND4C_ENST00000380432.2_Silent_p.I1182I|DENND4C_ENST00000540671.1_Silent_p.I512I|DENND4C_ENST00000434457.2_Silent_p.I1467I|DENND4C_ENST00000602925.1_Silent_p.I1418I			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1182						integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						ACACAAGTATCTCAGGGTTGG	0.433000													18	83					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72345521	72345521	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:72345521C>T	ENST00000299687.5	+	1	2546	c.2546C>T	c.(2545-2547)tCa>tTa	p.S849L	ZNF407_ENST00000582337.1_Missense_Mutation_p.S849L|ZNF407_ENST00000577538.1_Missense_Mutation_p.S849L|ZNF407_ENST00000309902.6_Missense_Mutation_p.S849L	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	849					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGTAACATCTCACGGACGTGT	0.438000													18	74					0	0	1	0	0
SCN4B	6330	broad.mit.edu	37	11	118007795	118007795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118007795C>T	ENST00000324727.4	-	5	780	c.634G>A	c.(634-636)Gag>Aag	p.E212K	SCN4B_ENST00000423160.2_5'UTR|SCN4B_ENST00000529878.1_Missense_Mutation_p.E78K	NM_001142349.1|NM_174934.3	NP_001135821.1|NP_777594.1	Q8IWT1	SCN4B_HUMAN	sodium channel, voltage-gated, type IV, beta subunit	212						voltage-gated sodium channel complex	voltage-gated sodium channel activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.33e-05)|Epithelial(105;0.00126)		AAGCCGTTCTCCGTGTTGTCA	0.577000													9	32					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450836	55450836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55450836C>T	ENST00000446217.1	-	6	1837	c.1435G>A	c.(1435-1437)Gga>Aga	p.G479R	NLRP7_ENST00000592784.1_Missense_Mutation_p.G451R|NLRP7_ENST00000340844.2_Missense_Mutation_p.G451R|NLRP7_ENST00000588756.1_Missense_Mutation_p.G451R|NLRP7_ENST00000448121.2_Missense_Mutation_p.G451R|NLRP7_ENST00000328092.5_Missense_Mutation_p.G451R|NLRP7_ENST00000590030.1_Missense_Mutation_p.G451R			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	451	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AGGATGTCTCCGTCCAGGAAC	0.622000													19	45					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622530	38622530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38622530C>T	ENST00000413689.1	-	17	3313	c.3120G>A	c.(3118-3120)ggG>ggA	p.G1040G	SCN5A_ENST00000423572.2_Silent_p.G1040G|SCN5A_ENST00000425664.1_Silent_p.G1040G|SCN5A_ENST00000455624.2_Silent_p.G1040G|SCN5A_ENST00000450102.2_Silent_p.G1040G|SCN5A_ENST00000449557.2_Silent_p.G1040G|SCN5A_ENST00000414099.2_Silent_p.G1040G|SCN5A_ENST00000451551.2_Silent_p.G1040G|SCN5A_ENST00000333535.4_Silent_p.G1040G|SCN5A_ENST00000443581.1_Silent_p.G1040G	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1040					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCTCTGGATCCCCGGGGGTGC	0.642000													3	27					0	0	1	0	0
IFIT1B	439996	broad.mit.edu	37	10	91144246	91144246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:91144246G>A	ENST00000371809.3	+	2	1256	c.1176G>A	c.(1174-1176)ggG>ggA	p.G392G	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	392							binding			endometrium(2)|large_intestine(3)|lung(8)	13						AACATCATGGGAAATCTCAAG	0.363000													28	74					0	0	1	0	0
CDX1	1044	broad.mit.edu	37	5	149546471	149546471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149546471C>T	ENST00000231656.8	+	1	114	c.32C>T	c.(31-33)tCg>tTg	p.S11L		NM_001804.2	NP_001795.2	P47902	CDX1_HUMAN	caudal type homeobox 1	11						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|lung(1)|ovary(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GACAAGGATTCGCCCGTGTAC	0.776000													4	11					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91134173	91134173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:91134173C>T	ENST00000373094.1	+	2	3779	c.2934C>T	c.(2932-2934)atC>atT	p.I978I	PCDH11X_ENST00000361724.1_Silent_p.I978I|PCDH11X_ENST00000504220.1_Silent_p.I978I|PCDH11X_ENST00000361655.2_Silent_p.I978I|PCDH11X_ENST00000373097.1_Silent_p.I978I|PCDH11X_ENST00000373088.1_Silent_p.I978I|PCDH11X_ENST00000406881.1_Silent_p.I978I|PCDH11X_ENST00000298274.8_Silent_p.I978I|PCDH11X_ENST00000395337.2_Silent_p.I978I	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	978					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GTGACTCTATCTCCAAGTGTT	0.517000													88	62					0	0	1	0	0
RTN4RL2	349667	broad.mit.edu	37	11	57235131	57235131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57235131G>A	ENST00000335099.3	+	2	398	c.81G>A	c.(79-81)gcG>gcA	p.A27A	RTN4RL2_ENST00000533205.1_Silent_p.A27A|RTN4RL2_ENST00000395120.2_Silent_p.A27A	NM_178570.1	NP_848665.1	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2	27					axon regeneration	anchored to plasma membrane	receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(2)	6						TGCCCCTGGCGGCCCCCAGCT	0.677000													26	101					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92577687	92577687	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92577687G>A	ENST00000298047.6	+	18	11171	c.11154G>A	c.(11152-11154)ctG>ctA	p.L3718L	FAT3_ENST00000533797.1_Silent_p.L53L|FAT3_ENST00000409404.2_Silent_p.L3718L|FAT3_ENST00000525166.1_Silent_p.L3568L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3718					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGCCTACCTGATCCAGAAGC	0.547000										TCGA Ovarian(4;0.039)			3	21					0	0	1	0	0
LTF	4057	broad.mit.edu	37	3	46497339	46497339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46497339C>T	ENST00000231751.4	-	4	741	c.446G>A	c.(445-447)gGg>gAg	p.G149E	LTF_ENST00000417439.1_Missense_Mutation_p.G149E|LTF_ENST00000426532.2_Missense_Mutation_p.G105E	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	149	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	ACGAAGTGTCCCTATAGGGAC	0.572000													21	37					0	0	1	0	0
DDX43	55510	broad.mit.edu	37	6	74104714	74104714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:74104714G>A	ENST00000370336.4	+	1	244	c.86G>A	c.(85-87)aGg>aAg	p.R29K	DDX43_ENST00000539829.1_Missense_Mutation_p.R29K|OOEP_ENST00000370363.1_5'UTR	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	29						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						GCGCCAGAGAGGAGGCCGGCG	0.642000													13	84					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81661830	81661830	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81661830C>T	ENST00000550584.2	-	28	3642	c.3347G>A	c.(3346-3348)tGg>tAg	p.W1116*	PPFIA2_ENST00000333447.7_Nonsense_Mutation_p.W1104*|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Nonsense_Mutation_p.W1101*|PPFIA2_ENST00000541570.2_Nonsense_Mutation_p.W652*|PPFIA2_ENST00000541017.1_Nonsense_Mutation_p.W302*|PPFIA2_ENST00000552948.1_Nonsense_Mutation_p.W1095*|PPFIA2_ENST00000548586.1_Nonsense_Mutation_p.W1110*|PPFIA2_ENST00000407050.4_Nonsense_Mutation_p.W1015*|PPFIA2_ENST00000550359.2_Nonsense_Mutation_p.W963*|PPFIA2_ENST00000443686.3_Nonsense_Mutation_p.W1011*|PPFIA2_ENST00000549396.1_Nonsense_Mutation_p.W1116*	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	1015										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TGCTTGTATCCAGCGAATAAC	0.373000													6	7					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033491	95033491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95033491C>T	ENST00000557004.1	+	3	1255	c.834C>T	c.(832-834)ttC>ttT	p.F278F	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000298841.5_Silent_p.F278F|SERPINA4_ENST00000555095.1_Silent_p.F278F			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	278					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		CCGTGTTTTTCATTCTCCCTA	0.478000													26	39					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537224	5537224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5537224G>A	ENST00000380184.1	-	1	711	c.448C>T	c.(448-450)Cac>Tac	p.H150Y	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	150										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CCCACAAAGTGGGCCAGTTCC	0.532000													9	94					0	0	1	0	0
ZW10	9183	broad.mit.edu	37	11	113614568	113614568	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113614568G>A	ENST00000200135.3	-	10	1611	c.1467C>T	c.(1465-1467)ctC>ctT	p.L489L		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	489					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TCTGATAGGCGAGTTCCATTA	0.403000													33	125					0	0	1	0	0
IGHV3-23	28442	broad.mit.edu	37	14	106725467	106725467	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106725467C>T	ENST00000390609.2	-	0	163																											TGTACCAAGCCTCCCCCAGAC	0.562000													59	221					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020498	56020498	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56020498C>T	ENST00000303059.3	+	1	823	c.823C>T	c.(823-825)Cta>Tta	p.L275L		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TGGCTCTCACCTAACTGGAGT	0.408000													59	154					0	0	1	0	0
TCP10L2	401285	broad.mit.edu	37	6	167591985	167591985	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:167591985G>A	ENST00000366832.2	+	5	743	c.612G>A	c.(610-612)agG>agA	p.R204R		NM_001145121.1	NP_001138593.1	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	204										endometrium(1)|kidney(2)|lung(3)	6						CCACTGGAAGGCCGACTCCCG	0.522000													18	80					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187419802	187419802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:187419802C>T	ENST00000358241.1	-	1	543	c.115G>A	c.(115-117)Gag>Aag	p.E39K		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	39					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		GGGGCCAGCTCACTGGGCTTG	0.592000													49	181					0	0	1	0	0
IFT57	55081	broad.mit.edu	37	3	107937477	107937477	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:107937477A>G	ENST00000264538.3	-	3	646	c.399T>C	c.(397-399)ccT>ccC	p.P133P		NM_018010.3	NP_060480.1	Q9NWB7	IFT57_HUMAN	intraflagellar transport 57 homolog (Chlamydomonas)	133					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	14			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TTAATTTTGAAGGAGGAAAAT	0.328000													11	40					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119770441	119770441	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:119770441G>A	ENST00000313400.4	-	7	1621	c.1521C>T	c.(1519-1521)tcC>tcT	p.S507S	ASTN2_ENST00000361209.2_Silent_p.S456S|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Silent_p.S507S			O75129	ASTN2_HUMAN	astrotactin 2	507						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TCACCCATGGGGAGGTGGCAT	0.572000													28	50					0	0	1	0	0
OCM2	4951	broad.mit.edu	37	7	97617821	97617821	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:97617821G>A	ENST00000257627.4	-	2	192	c.101C>T	c.(100-102)tCa>tTa	p.S34L	OCM2_ENST00000473987.2_5'UTR	NM_006188.3	NP_006179.2	P0CE71	OCM2_HUMAN	oncomodulin 2	34							calcium ion binding			lung(4)	4						GGAGAGGCCTGACGTCTGGAA	0.463000													90	205					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033447	82033447	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82033447G>A	ENST00000328945.5	-	3	578	c.451C>T	c.(451-453)Cac>Tac	p.H151Y	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	151					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CGAGAGTAGTGATCAGGGTGG	0.507000													40	64					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595369	55595369	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55595369C>T	ENST00000378397.1	+	1	675	c.675C>T	c.(673-675)atC>atT	p.I225I		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				TCACCACTATCCTGAAGATAC	0.483000										HNSCC(27;0.073)			45	103					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54791248	54791248	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54791248G>A	ENST00000293379.4	-	29	3228	c.2967C>T	c.(2965-2967)acC>acT	p.T989T	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	989					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CTTCTGCCTTGGTCCATTGCA	0.522000													12	41					0	0	1	0	0
THSD4	79875	broad.mit.edu	37	15	72039235	72039235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72039235C>T	ENST00000355327.3	+	13	2229	c.2095C>T	c.(2095-2097)Cgc>Tgc	p.R699C	THSD4_ENST00000567838.1_3'UTR|THSD4_ENST00000357769.4_Missense_Mutation_p.R339C|THSD4_ENST00000261862.6_Missense_Mutation_p.R699C			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	699	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						CATGCAGCACCGCCAGGTTCT	0.622000													12	72					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127797208	127797208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:127797208C>T	ENST00000556132.1	-	6	2827	c.1963G>A	c.(1963-1965)Gag>Aag	p.E655K	SOGA3_ENST00000481848.2_Missense_Mutation_p.E655K|SOGA3_ENST00000525778.1_Missense_Mutation_p.E655K|SOGA3_ENST00000368268.2_Missense_Mutation_p.E655K|SOGA3_ENST00000465909.2_Missense_Mutation_p.E655K	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	655						integral to membrane											AGCTCCGTCTCGTCTTCCACC	0.632000													9	60					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43816702	43816702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43816702C>T	ENST00000382031.1	+	5	3776	c.3745C>T	c.(3745-3747)Cat>Tat	p.H1249Y	MAP1A_ENST00000300231.5_Missense_Mutation_p.H1011Y|MAP1A_ENST00000399453.1_Missense_Mutation_p.H1011Y			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1011						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CACACCCTTTCATCAGTCCCC	0.572000													32	74					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69445293	69445293	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:69445293C>T	ENST00000337103.4	+	6	2273	c.681C>T	c.(679-681)ctC>ctT	p.L227L	C8orf34_ENST00000348340.2_Silent_p.L252L|C8orf34_ENST00000539993.1_Silent_p.L252L|C8orf34_ENST00000518698.1_Silent_p.L338L			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	252					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCGCAATGCTCTCTCAAGATT	0.373000													45	118					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45695845	45695845	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:45695845C>T	ENST00000303230.4	-	1	408	c.351G>A	c.(349-351)caG>caA	p.Q117Q		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	117	Involved in subunit assembly (By similarity).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CCACCGCCTTCTGGCTCCCAA	0.602000													15	59					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155757553	155757553	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155757553G>A	ENST00000159060.2	-	7	899	c.798_splice	c.e7+1	p.S266_splice		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	266	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CATTCTTACCGAGGGTTCCTT	0.438000													32	65					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4356353	4356353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4356353G>A	ENST00000355530.2	+	8	1246	c.966G>A	c.(964-966)ggG>ggA	p.G322G	SPNS3_ENST00000576069.1_3'UTR|SPNS3_ENST00000333476.2_Silent_p.G195G	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	322					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GCGTCATTGGGGTCATCTTGG	0.587000													36	58					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75113440	75113440	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75113440A>G	ENST00000309664.5	+	9	1071	c.932A>G	c.(931-933)gAg>gGg	p.E311G	LMAN1L_ENST00000379709.3_Missense_Mutation_p.E299G|RP11-414J4.2_ENST00000564823.1_RNA	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	311						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GACCTGGAGGAGACGCTGGGC	0.627000													2	9					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107710318	107710318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107710318G>A	ENST00000388781.3	-	18	2220	c.2137C>T	c.(2137-2139)Ccc>Tcc	p.P713S	LAMB4_ENST00000205386.4_Missense_Mutation_p.P713S|LAMB4_ENST00000388780.3_Missense_Mutation_p.P713S	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	713	Laminin IV type B.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TTGATTTGGGGAATAAGGCCA	0.358000													28	69					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1732664	1732664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1732664C>T	ENST00000313288.4	+	5	1542	c.1436C>T	c.(1435-1437)gCc>gTc	p.A479V		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	479						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CAGTTGGCAGCCGAGACCCCA	0.632000													6	53					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28493824	28493824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28493824C>T	ENST00000412168.2	+	1	123	c.34C>T	c.(34-36)Ccc>Tcc	p.P12S	GPX5_ENST00000469384.1_Missense_Mutation_p.P12S|GPX6_ENST00000483058.1_Intron	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	12					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	CCATCTGCTTCCCCTTCTCCT	0.498000													79	168					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1808329	1808329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1808329C>T	ENST00000340107.4	+	16	2349	c.2093C>T	c.(2092-2094)cCc>cTc	p.P698L	FGFR3_ENST00000352904.1_Missense_Mutation_p.P584L|FGFR3_ENST00000440486.2_Missense_Mutation_p.P696L|FGFR3_ENST00000412135.2_Missense_Mutation_p.P584L|FGFR3_ENST00000260795.2_Missense_Mutation_p.P696L|FGFR3_ENST00000481110.2_Silent_p.P673P	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	696	Protein kinase.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TCCCCGTACCCCGGCATCCCT	0.647000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				13	47					0	0	1	0	0
SS18	6760	broad.mit.edu	37	18	23612462	23612462	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:23612462A>G	ENST00000415083.2	-	10	1186	c.1131T>C	c.(1129-1131)ccT>ccC	p.P377P	SS18_ENST00000545952.1_Silent_p.P294P|SS18_ENST00000542743.1_Silent_p.P294P|SS18_ENST00000539849.1_Silent_p.P295P|SS18_ENST00000542420.2_Silent_p.P354P|SS18_ENST00000269137.7_Silent_p.P346P	NM_001007559.1|NM_005637.2	NP_001007560.1|NP_005628.2	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	377	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX2(706)|SS18/SSX1(1169)|SS18/SSX4(12)	endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(1)	19	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					GTGGGTAGTTAGGATACTGAG	0.498000			T	"""SSX1,  SSX2"""	synovial sarcoma								24	105					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065396	9065396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9065396G>A	ENST00000397910.4	-	3	22253	c.22050C>T	c.(22048-22050)tcC>tcT	p.S7350S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7352	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTATTACCAAGGAGGGAGTGG	0.488000													16	45					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68995622	68995622	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68995622G>A	ENST00000288368.4	+	18	2303	c.2027_splice	c.e18+1	p.E676_splice	PREX2_ENST00000529398.1_3'UTR|RP11-403D15.2_ENST00000526901.1_RNA	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	676					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AAAGCCAAGAGAGTAAGTTGT	0.318000													19	56					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58512360	58512360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58512360C>T	ENST00000302819.5	-	10	1470	c.1179G>A	c.(1177-1179)atG>atA	p.M393I	ACOX2_ENST00000459701.2_Missense_Mutation_p.M379I	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	393					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TCATGGCCTTCATGCCCGTGC	0.607000													8	57					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135347379	135347379	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:135347379C>T	ENST00000463117.2	+	8	1217	c.945C>T	c.(943-945)ctC>ctT	p.L315L	CYP2E1_ENST00000252945.3_Silent_p.L315L|SPRN_ENST00000541506.1_Intron			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	315					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	TCCTGATTCTCATGAAATACC	0.542000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				28	62					0	0	1	0	0
SPOCK2	9806	broad.mit.edu	37	10	73822580	73822580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73822580C>T	ENST00000373109.2	-	11	1657	c.1213G>A	c.(1213-1215)Gag>Aag	p.E405K	SPOCK2_ENST00000317376.4_Missense_Mutation_p.E405K|SPOCK2_ENST00000536168.1_Missense_Mutation_p.E405K	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	405	Glu-rich.				extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						tcggcctcctcgcctgcttcc	0.662000													7	21					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57399115	57399115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57399115G>A	ENST00000543257.1	-	11	1855	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F	C8B_ENST00000371237.4_Missense_Mutation_p.S482F|C8B_ENST00000535057.1_Missense_Mutation_p.S420F	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	482	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						CACTGTGCTGGAATAGGCAAA	0.473000													18	45					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62933664	62933664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62933664G>A	ENST00000306494.6	-	7	1136	c.1137C>T	c.(1135-1137)ttC>ttT	p.F379F	SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	379					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						TCTGCAACAGGAAAACATTGT	0.478000													25	64					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173517593	173517593	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173517593C>T	ENST00000367714.3	-	12	1818	c.1396G>A	c.(1396-1398)Gaa>Aaa	p.E466K	SLC9C2_ENST00000536496.1_Missense_Mutation_p.E364K|SLC9C2_ENST00000466087.1_5'UTR	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	466					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										AAAATTTTTTCTGTTTTAAAT	0.348000													22	60					0	0	1	0	0
LINC00661	126536	broad.mit.edu	37	19	16131429	16131429	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16131429G>A	ENST00000549354.1	+	0	260				AC004790.3_ENST00000592886.1_lincRNA	NR_026828.1																						CAGTGCCCTGGAAGTGAAGGT	0.622000													13	28					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130878039	130878039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130878039G>A	ENST00000357462.5	-	1	143	c.50C>T	c.(49-51)cCa>cTa	p.P17L	POTEF_ENST00000360967.5_Missense_Mutation_p.P17L|POTEF_ENST00000361163.4_Missense_Mutation_p.P17L|POTEF_ENST00000409914.2_Missense_Mutation_p.P17L			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	17						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						GAGACCAAATGGCTTCTTCAC	0.562000													18	184					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587813	247587813	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247587813G>A	ENST00000366497.2	+	4	1848	c.1068G>A	c.(1066-1068)gaG>gaA	p.E356E	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Silent_p.E356E|NLRP3_ENST00000336119.3_Silent_p.E356E|NLRP3_ENST00000348069.2_Silent_p.E356E|NLRP3_ENST00000391828.3_Silent_p.E356E|NLRP3_ENST00000391827.2_Silent_p.E356E	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	356	NACHT.		E -> D (in CINCA).		detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGGCCCTGGAGAAACTGCAGC	0.552000													23	76					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17682618	17682618	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17682618G>A	ENST00000375448.4	+	12	1477	c.1451G>A	c.(1450-1452)aGg>aAg	p.R484K	PADI4_ENST00000487048.1_3'UTR	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	484					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GCACCCGACAGGAAGGTACAG	0.592000													14	46					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411681	23411681	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23411681C>T	ENST00000379361.4	+	3	2906	c.2046C>T	c.(2044-2046)ttC>ttT	p.F682F		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	682					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TCATCGTCTTCAATCCGTCCT	0.493000													37	19					0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151400307	151400307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151400307G>A	ENST00000271715.2	-	7	1384	c.1070C>T	c.(1069-1071)tCa>tTa	p.S357L	POGZ_ENST00000409503.1_Missense_Mutation_p.S348L|POGZ_ENST00000491586.1_Missense_Mutation_p.S304L|POGZ_ENST00000531094.1_Missense_Mutation_p.S295L|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000392723.1_Missense_Mutation_p.S304L|POGZ_ENST00000368863.2_Missense_Mutation_p.S262L|POGZ_ENST00000361398.3_Missense_Mutation_p.S304L	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	357					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACCTTTCATTGAAGACTCAGG	0.448000													6	27					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1544488	1544488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1544488C>T	ENST00000345913.4	+	16	2832	c.2741C>T	c.(2740-2742)tCg>tTg	p.S914L	TPO_ENST00000382198.1_Missense_Mutation_p.S741L|TPO_ENST00000349624.3_Missense_Mutation_p.S741L|TPO_ENST00000329066.4_Missense_Mutation_p.S914L|TPO_ENST00000497517.2_Intron|TPO_ENST00000382201.3_Missense_Mutation_p.S857L|TPO_ENST00000337415.3_Intron|TPO_ENST00000346956.3_Missense_Mutation_p.S870L	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	914					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCTCAGGACTCGGAGCAGGTG	0.652000													21	45					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15415903	15415903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:15415903G>A	ENST00000281513.5	-	44	5454	c.5429C>T	c.(5428-5430)cCt>cTt	p.P1810L	NBAS_ENST00000441750.1_Missense_Mutation_p.P1690L	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1810										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TGCTTCAAGAGGACTCATGTT	0.368000													19	77					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61990996	61990996	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61990996G>A	ENST00000370263.4	-	2	353	c.132C>T	c.(130-132)ctC>ctT	p.L44L	CHRNA4_ENST00000463705.1_Intron	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	44					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AACCGGAGAAGAGTTTCTTCA	0.652000													7	77					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80770937	80770937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80770937C>T	ENST00000458043.2	+	57	6795	c.6789C>T	c.(6787-6789)atC>atT	p.I2263I	OTOGL_ENST00000547103.1_Silent_p.I2251I|OTOGL_ENST00000546620.1_Silent_p.I282I	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						AGAAAGTGATCATTAAATCGG	0.308000													10	32					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61261588	61261588	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61261588G>A	ENST00000344731.5	+	6	574		c.e6-1		SERPINB13_ENST00000269489.5_Splice_Site	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13						regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						TTCATTTGCAGAAAAAATCAA	0.383000													10	45					0	0	1	0	0
PKN1	5585	broad.mit.edu	37	19	14568910	14568910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14568910C>T	ENST00000242783.6	+	8	1398	c.1233C>T	c.(1231-1233)ggC>ggT	p.G411G	PKN1_ENST00000342216.4_Silent_p.G417G	NM_002741.3	NP_002732.3	Q16512	PKN1_HUMAN	protein kinase N1	411	C2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)	31						AGCCATGTGGCCCCAATGCCT	0.577000													43	200					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42992602	42992602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42992602C>T	ENST00000253408.5	-	1	318	c.253G>A	c.(253-255)Gag>Aag	p.E85K	GFAP_ENST00000586793.1_Missense_Mutation_p.E85K|GFAP_ENST00000588735.1_Intron|GFAP_ENST00000591327.1_5'UTR|GFAP_ENST00000435360.2_Missense_Mutation_p.E85K	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	85	Coil 1A.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				CGAACCTTCTCGATGTAGCTG	0.602000													22	27					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20328616	20328616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20328616G>A	ENST00000302555.5	-	8	1484	c.1335C>T	c.(1333-1335)ttC>ttT	p.F445F	GP2_ENST00000381360.5_Silent_p.F301F|GP2_ENST00000381362.4_Silent_p.F448F|GP2_ENST00000341642.5_Silent_p.F298F			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	448	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CAGCAAACATGAACATCTGAA	0.488000													9	81					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92088157	92088157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92088157C>T	ENST00000298047.6	+	1	2896	c.2879C>T	c.(2878-2880)aCc>aTc	p.T960I	FAT3_ENST00000541502.1_Missense_Mutation_p.T960I|FAT3_ENST00000409404.2_Missense_Mutation_p.T960I|FAT3_ENST00000525166.1_Missense_Mutation_p.T810I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	960	Cadherin 9.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.T960S(1)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGCTTGAGACCCATGATCCA	0.468000										TCGA Ovarian(4;0.039)			29	76					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38885838	38885838	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38885838G>A	ENST00000359357.3	+	68	10049	c.9795G>A	c.(9793-9795)ggG>ggA	p.G3265G	DNAH8_ENST00000449981.2_Silent_p.G3482G|DNAH8_ENST00000441566.1_Silent_p.G3229G					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AAGTCTGTGGGAATGTGGCTG	0.388000													26	66					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39991461	39991461	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39991461C>T	ENST00000332312.3	-	4	940	c.748G>A	c.(748-750)Gag>Aag	p.E250K		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	250						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				CTTAGGATCTCGTCTAAGGGA	0.602000													18	55					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130312089	130312089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130312089G>A	ENST00000358511.6	+	16	4494	c.4463G>A	c.(4462-4464)gGa>gAa	p.G1488E	COL6A6_ENST00000453409.2_Missense_Mutation_p.G1488E	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1488	Triple-helical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						GGAGATGAGGGATCTCAGGTA	0.363000													15	54					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605290	171605290	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171605290G>A	ENST00000037502.5	-	3	1349	c.1290C>T	c.(1288-1290)ttC>ttT	p.F430F		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	430	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CACAGATGATGAAGGCATTGG	0.507000													47	131					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31475943	31475943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31475943C>T	ENST00000457010.2	+	4	2300	c.1599C>T	c.(1597-1599)tcC>tcT	p.S533S	ARMC5_ENST00000408912.3_Silent_p.S628S|ARMC5_ENST00000563544.1_Silent_p.S533S|ARMC5_ENST00000268314.4_Silent_p.S533S|ARMC5_ENST00000412665.2_Silent_p.S177S|ARMC5_ENST00000538189.1_Silent_p.S565S	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	533							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CGCGCTTTTCCCAGGCCCCTG	0.731000													8	11					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61844941	61844941	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61844941G>A	ENST00000280772.1	-	31	4010	c.3819C>T	c.(3817-3819)gtC>gtT	p.V1273V	ANK3_ENST00000503366.1_Silent_p.V1274V|ANK3_ENST00000373827.2_Silent_p.V1267V|ANK3_ENST00000355288.2_Silent_p.V407V	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1273					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTGTAAAGGAGACACAATCTT	0.383000													28	87					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21991161	21991161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21991161G>A	ENST00000594012.1	-	7	2174	c.1660C>T	c.(1660-1662)Cat>Tat	p.H554Y	ZNF43_ENST00000354959.4_Missense_Mutation_p.H560Y|ZNF43_ENST00000598381.1_Missense_Mutation_p.H554Y|ZNF43_ENST00000595461.1_Missense_Mutation_p.H554Y	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TCTCCAGTATGAATCCTCTTA	0.363000													37	69					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47506910	47506910	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47506910G>A	ENST00000285039.7	-	9	1259	c.960C>T	c.(958-960)tcC>tcT	p.S320S		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	320	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TCATCTGATGGGACTCTTTCA	0.393000													9	52					0	0	1	0	0
VRK2	7444	broad.mit.edu	37	2	58359011	58359011	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:58359011C>T	ENST00000435505.2	+	12	1490	c.745C>T	c.(745-747)Ccc>Tcc	p.P249S	VRK2_ENST00000340157.4_Missense_Mutation_p.P249S|VRK2_ENST00000440705.2_Missense_Mutation_p.P226S|VRK2_ENST00000412104.2_Missense_Mutation_p.P249S|VRK2_ENST00000417641.2_Missense_Mutation_p.P249S			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	249	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						TGGGAAACTTCCCTGGGAACA	0.473000													38	84					0	0	1	0	0
TKT	7086	broad.mit.edu	37	3	53263106	53263106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53263106G>A	ENST00000462138.1	-	10	1400	c.1312C>T	c.(1312-1314)Cgg>Tgg	p.R438W	TKT_ENST00000423525.2_Missense_Mutation_p.R438W|TKT_ENST00000461139.1_5'UTR|TKT_ENST00000296289.6_Missense_Mutation_p.R391W|TKT_ENST00000423516.1_Missense_Mutation_p.R446W			P29401	TKT_HUMAN	transketolase	438					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	GGGACTGACCGAAACATAGCC	0.542000													62	150					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052360	44052360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:44052360G>A	ENST00000306006.6	-	2	1820	c.1168C>T	c.(1168-1170)Ctt>Ttt	p.L390F	ZNF239_ENST00000535642.1_Missense_Mutation_p.L390F|ZNF239_ENST00000374446.2_Missense_Mutation_p.L390F|ZNF239_ENST00000426961.1_Missense_Mutation_p.L390F	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGGATGCGAAGATCCGAGCTC	0.527000													8	78					0	0	1	0	0
QRFPR	84109	broad.mit.edu	37	4	122250491	122250491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122250491G>A	ENST00000394427.2	-	6	1685	c.1274C>T	c.(1273-1275)tCt>tTt	p.S425F	QRFPR_ENST00000334383.5_3'UTR	NM_198179.2	NP_937822.2	Q96P65	QRFPR_HUMAN	pyroglutamylated RFamide peptide receptor	425						plasma membrane	neuropeptide Y receptor activity			endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(2)|skin(3)|stomach(1)	28						GTCTAAAGGAGAATTCTCAGC	0.363000													25	109					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55874940	55874940	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55874940T>A	ENST00000388975.3	-	8	945	c.829A>T	c.(829-831)Aat>Tat	p.N277Y		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	277					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCACAGTGATTTTCATTTTCC	0.308000													23	44					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3116432	3116432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3116432C>T	ENST00000400569.3	-	21	3533	c.3200G>A	c.(3199-3201)cGg>cAg	p.R1067Q	MYOM1_ENST00000356443.4_Missense_Mutation_p.R1067Q|MYOM1_ENST00000261606.7_Missense_Mutation_p.R971Q			P52179	MYOM1_HUMAN	myomesin 1	1067	Fibronectin type-III 5.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GACCGGAGTCCGCCCGGAGTG	0.552000													10	21					0	0	1	0	0
SLC27A4	10999	broad.mit.edu	37	9	131117932	131117932	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131117932C>T	ENST00000300456.3	+	12	1748	c.1631C>T	c.(1630-1632)aCc>aTc	p.T544I	SLC27A4_ENST00000372870.1_Missense_Mutation_p.T138I	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	544					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						CCCCCAGGAACCGAGGGCCGG	0.657000													19	72					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89347138	89347138	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89347138G>A	ENST00000301030.4	-	9	6272	c.5812C>T	c.(5812-5814)Ccc>Tcc	p.P1938S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1938S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1938	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCGCTGAAGGGACCCTCGTCC	0.697000													20	47					0	0	1	0	0
WDR1	9948	broad.mit.edu	37	4	10084736	10084736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:10084736G>A	ENST00000382452.2	-	10	1388	c.1106C>T	c.(1105-1107)tCc>tTc	p.S369F	WDR1_ENST00000499869.2_Missense_Mutation_p.S369F|WDR1_ENST00000502702.1_Missense_Mutation_p.S229F|WDR1_ENST00000382451.2_Missense_Mutation_p.S229F|WDR1_ENST00000515743.1_5'UTR	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	369					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		GGTCATCCTGGACACCTGGTT	0.602000													13	27					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42571329	42571329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42571329C>T	ENST00000372899.1	+	5	793	c.535C>T	c.(535-537)Cct>Tct	p.P179S	UBR2_ENST00000372903.2_Missense_Mutation_p.P179S|UBR2_ENST00000372901.1_Missense_Mutation_p.P179S	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	179					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			ctttCAGGATCCTCTTGTTCA	0.303000													14	19					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65413779	65413779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65413779C>T	ENST00000394224.3	+	7	1647	c.1351C>T	c.(1351-1353)Cgc>Tgc	p.R451C	SIPA1_ENST00000527525.1_Missense_Mutation_p.R451C|SIPA1_ENST00000394227.3_Missense_Mutation_p.R451C|SIPA1_ENST00000534313.1_Missense_Mutation_p.R451C	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	451	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						CACCACCATCCGCTCGCACTT	0.632000													36	88					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6924124	6924124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6924124G>A	ENST00000011653.4	+	5	831	c.573G>A	c.(571-573)aaG>aaA	p.K191K	CD4_ENST00000538827.1_3'UTR|CD4_ENST00000541982.1_Silent_p.K136K	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	191	Ig-like C2-type 1.		K -> E (in dbSNP:rs28917504).		cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				AGAACCAGAAGAAGGTGGAGT	0.577000													6	31					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19701585	19701585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:19701585C>T	ENST00000284885.3	-	15	1714	c.1681G>A	c.(1681-1683)Gga>Aga	p.G561R		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	561	CUB 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						ATATTCTTTCCTTTTTGTGCA	0.308000													13	39					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476041	120476041	+	Silent	SNP	C	C	T	rs140976297		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:120476041C>T	ENST00000355622.6	+	3	1736	c.1635C>T	c.(1633-1635)tcC>tcT	p.S545S	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.S505S	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	545					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GTCTGAACTCCCTCCAGGTTC	0.378000													11	55					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79092621	79092621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79092621G>A	ENST00000388820.4	-	2	579	c.369C>T	c.(367-369)gcC>gcT	p.A123A	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	123					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CCGGGGTGTGGGCCCGGATGT	0.731000													8	29					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30126365	30126365	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30126365G>A	ENST00000449742.2	-	3	642	c.567C>T	c.(565-567)ttC>ttT	p.F189F	TRIM10_ENST00000376704.3_Silent_p.F189F	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	189						cytoplasm	zinc ion binding	p.F189F(1)		ovary(1)	1						TCAGGTGTGCGAACTCAGAAA	0.517000													100	225					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48117823	48117823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48117823C>T	ENST00000311303.3	-	28	4335	c.3990G>A	c.(3988-3990)ggG>ggA	p.G1330G	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_3'UTR	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	1330	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				CCTATACCTTCCCATTTTCCA	0.483000													26	84					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35667306	35667306	+	Missense_Mutation	SNP	G	G	A	rs144477950		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35667306G>A	ENST00000440995.2	+	9	1300	c.1300G>A	c.(1300-1302)Gat>Aat	p.D434N	SPEF2_ENST00000282469.6_Missense_Mutation_p.D434N|SPEF2_ENST00000356031.3_Missense_Mutation_p.D434N|SPEF2_ENST00000509059.1_Missense_Mutation_p.D434N			Q9C093	SPEF2_HUMAN	sperm flagellar 2	434					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGAAATTTTGGATCAAATAGT	0.328000													17	38					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34092618	34092618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34092618C>T	ENST00000397527.1	+	30	7141	c.6421C>T	c.(6421-6423)Ctt>Ttt	p.L2141F	CEP250_ENST00000342580.4_Missense_Mutation_p.L2085F	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	2141	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			ATCTCTAAAACTTGATTCTTT	0.557000													7	95					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104239033	104239033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104239033G>A	ENST00000374851.1	-	4	1489	c.342C>T	c.(340-342)ggC>ggT	p.G114G	TMEM246_ENST00000374848.3_Silent_p.G114G|RP11-490D19.6_ENST00000424154.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000431507.1_RNA|RP11-490D19.6_ENST00000450109.1_RNA|TMEM246_ENST00000374847.1_Silent_p.G114G			Q9BRR3	CI125_HUMAN	transmembrane protein 246	114						integral to membrane											CGTAGTGGAAGCCAGGCTGCC	0.622000													5	54					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73235205	73235205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:73235205G>A	ENST00000377110.2	-	15	2123	c.1880C>T	c.(1879-1881)cCt>cTt	p.P627L	TRPM3_ENST00000396280.5_Missense_Mutation_p.P476L|TRPM3_ENST00000357533.2_Missense_Mutation_p.P631L|TRPM3_ENST00000377111.2_Missense_Mutation_p.P627L|TRPM3_ENST00000408909.2_Missense_Mutation_p.P486L|TRPM3_ENST00000360823.2_Missense_Mutation_p.P489L|TRPM3_ENST00000377106.1_Missense_Mutation_p.P499L|TRPM3_ENST00000396285.1_Missense_Mutation_p.P474L|TRPM3_ENST00000423814.3_Missense_Mutation_p.P654L|TRPM3_ENST00000358082.3_Missense_Mutation_p.P489L|TRPM3_ENST00000377105.1_Missense_Mutation_p.P486L|TRPM3_ENST00000396292.4_Missense_Mutation_p.P499L	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	652						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GTTGATCTCAGGATCATCCAA	0.498000													48	157					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073120	17073120	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17073120G>A	ENST00000359963.3	-	1	580	c.321C>T	c.(319-321)ttC>ttT	p.F107F		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	107					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.F107F(1)		breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCAGAACCACGAAGGCTGTGC	0.662000													20	64					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31424182	31424182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31424182C>T	ENST00000389202.2	+	15	1780	c.1731C>T	c.(1729-1731)tcC>tcT	p.S577S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	577					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCCAGCTCTCCCCCAGGCTGC	0.602000													47	85					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240674	39240674	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39240674G>A	ENST00000391417.4	+	1	216	c.216G>A	c.(214-216)acG>acA	p.T72T		NM_033061.3	NP_149050.3			keratin associated protein 4-7											NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GCTGTGAGACGACctgctgcc	0.657000													13	31					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14809496	14809496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14809496C>T	ENST00000261170.3	-	12	1556	c.1420G>A	c.(1420-1422)Gaa>Aaa	p.E474K		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	474					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						AAGATATTTTCAGGAGGAATG	0.358000													34	107					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69416504	69416504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69416504C>T	ENST00000317746.2	-	5	1246	c.1204G>A	c.(1204-1206)Gat>Aat	p.D402N		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	402					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						GCAATGTTATCATGTTGATCC	0.448000													53	143					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976700	20976700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20976700C>T	ENST00000261383.3	-	53	8505	c.8506G>A	c.(8506-8508)Gat>Aat	p.D2836N	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2836	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AATTTCAGATCCCCAAGAATC	0.413000													19	91					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110295781	110295781	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110295781G>A	ENST00000369805.3	-	13	1390	c.1161C>T	c.(1159-1161)ccC>ccT	p.P387P	RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361852.4_Silent_p.P386P|EPS8L3_ENST00000361965.4_Silent_p.P386P	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	386						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CTGAGAATGTGGGTTGGTAGG	0.572000													11	87					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123452725	123452725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123452725C>T	ENST00000360772.3	-	11	1496	c.1118G>A	c.(1117-1119)aGg>aAg	p.R373K	MYLK_ENST00000346322.5_Missense_Mutation_p.R373K|MYLK_ENST00000359169.1_Missense_Mutation_p.R373K|MYLK_ENST00000475616.1_Missense_Mutation_p.R373K|MYLK_ENST00000360304.3_Missense_Mutation_p.R373K			Q15746	MYLK_HUMAN	myosin light chain kinase	373					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGGAGCTGGCCTCTTCCTCTC	0.612000													38	103					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101523896	101523896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101523896C>T	ENST00000388948.3	+	4	784	c.425C>T	c.(424-426)tCc>tTc	p.S142F	LRRK1_ENST00000532029.2_Missense_Mutation_p.S142F|LRRK1_ENST00000284395.5_Intron	NM_024652.3	NP_078928.3	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	142					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTGCTTGAGTCCTTACCAGGT	0.527000													25	78					0	0	1	0	0
GJB2	2706	broad.mit.edu	37	13	20763615	20763615	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:20763615G>A	ENST00000382844.1	-	1	304	c.106C>T	c.(106-108)Ctc>Ttc	p.L36F	GJB2_ENST00000382848.4_Missense_Mutation_p.L36F			P29033	CXB2_HUMAN	gap junction protein, beta 2, 26kDa	36					cell-cell signaling|cellular membrane organization|gap junction assembly|sensory perception of sound|transport	connexon complex|ER-Golgi intermediate compartment|integral to membrane				breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7		all_cancers(29;3.95e-22)|all_epithelial(30;2.36e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000435)|Epithelial(112;0.000722)|OV - Ovarian serous cystadenocarcinoma(117;0.0096)|Lung(94;0.0236)|LUSC - Lung squamous cell carcinoma(192;0.0738)		GCCACAACGAGGATCATAATG	0.542000									Keratitis, Ichthyosis and Deafness syndrome		OREG0022282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	86					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23203759	23203759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23203759G>A	ENST00000300061.2	+	4	848	c.705G>A	c.(703-705)atG>atA	p.M235I		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	235					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TACACTACATGAACATCATGG	0.488000													11	91					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72848173	72848173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72848173G>A	ENST00000293190.5	-	3	1123	c.977C>T	c.(976-978)cCt>cTt	p.P326L	GRIN2C_ENST00000347612.4_Missense_Mutation_p.P326L	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	326					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CTCCCGGGCAGGGCTGACGGG	0.716000													5	15					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57865164	57865164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57865164C>T	ENST00000228682.2	+	12	2732	c.2641C>T	c.(2641-2643)Ctg>Ttg	p.L881L	GLI1_ENST00000543426.1_Silent_p.L753L|GLI1_ENST00000546141.1_Silent_p.L840L	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	881					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			CAGGCCTTGCCTGGACTTTGA	0.552000													17	132					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246811221	246811221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:246811221C>T	ENST00000366513.4	+	9	1987	c.1718C>T	c.(1717-1719)tCc>tTc	p.S573F	CNST_ENST00000483271.1_3'UTR|CNST_ENST00000366512.3_Missense_Mutation_p.S573F	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	573					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						GACGACGACTCCGATCTCCTT	0.408000													53	237					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57569316	57569316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57569316C>T	ENST00000243077.3	+	23	4087	c.3621C>T	c.(3619-3621)tcC>tcT	p.S1207S		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1207	EGF-like 5.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTGTGTGTTCCTGCCCTCTGG	0.582000											OREG0021937	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	67					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156756843	156756843	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156756843C>T	ENST00000271526.4	+	3	1232	c.960C>T	c.(958-960)ccC>ccT	p.P320P	PRCC_ENST00000491853.1_3'UTR|PRCC_ENST00000353233.3_Silent_p.P320P	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	320					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCAATGCCCCCCTTGAATTCA	0.572000			T	TFE3	papillary renal								82	168					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31523087	31523087	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31523087G>A	ENST00000261592.5	-	9	1781	c.1484C>T	c.(1483-1485)tCa>tTa	p.S495L	NOL4_ENST00000269185.4_Intron|NOL4_ENST00000535384.1_Missense_Mutation_p.S210L|NOL4_ENST00000535475.1_Missense_Mutation_p.S276L|NOL4_ENST00000589544.1_Intron|NOL4_ENST00000538587.1_Missense_Mutation_p.S421L	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	495						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						CTCACAAGCTGAAGCCAAGAT	0.423000													20	81					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33235498	33235498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33235498G>A	ENST00000401073.2	+	6	788	c.718G>A	c.(718-720)Gag>Aag	p.E240K	KIAA1522_ENST00000373481.3_Missense_Mutation_p.E192K|KIAA1522_ENST00000373480.1_Missense_Mutation_p.E181K|KIAA1522_ENST00000294521.3_Intron	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	181										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GAATGAGCGTGAGGCACCAGG	0.701000													8	25					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120935629	120935629	+	Missense_Mutation	SNP	C	C	T	rs147434701	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120935629C>T	ENST00000310396.5	+	23	3471	c.3004C>T	c.(3004-3006)Cat>Tat	p.H1002Y		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		ATCGCCATATCATGTCAGAGG	0.378000													45	104					0	0	1	0	0
OR6C75	390323	broad.mit.edu	37	12	55758950	55758950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55758950C>T	ENST00000343399.3	+	1	56	c.56C>T	c.(55-57)cCa>cTa	p.P19L		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						ACAAGTGACCCACAGTGGCAG	0.363000													56	183					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120263021	120263021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120263021G>A	ENST00000392521.2	-	8	960	c.905C>T	c.(904-906)cCc>cTc	p.P302L	CIT_ENST00000261833.7_Missense_Mutation_p.P302L	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	302	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTCTGCGAAGGGGGATCTCCC	0.468000													35	73					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68968190	68968190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68968190C>T	ENST00000288368.4	+	10	1496	c.1219C>T	c.(1219-1221)Cct>Tct	p.P407S	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	407	DEP 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GACTACGTTCCCTAAATGCTT	0.398000													41	73					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112162920	112162920	+	Nonstop_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:112162920G>C	ENST00000520401.1	+	1	11	c.11G>C	c.(10-12)tGa>tCa	p.*4S	APC_ENST00000457016.1_Missense_Mutation_p.L508F|APC_ENST00000257430.4_Missense_Mutation_p.L508F|APC_ENST00000508376.2_Missense_Mutation_p.L508F														p.?(1)									TGACAAACTTGACTTTTGGAG	0.333000													8	80					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14565186	14565186	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14565186C>T	ENST00000273083.3	-	0	488							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						TTGAAATGATCCTGGGGTTAT	0.517000													8	19					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70516049	70516049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70516049C>T	ENST00000265872.6	+	14	1764	c.1645C>T	c.(1645-1647)Cgc>Tgc	p.R549C	CCAR1_ENST00000543719.1_Missense_Mutation_p.R534C|CCAR1_ENST00000483264.1_3'UTR|CCAR1_ENST00000535016.1_Missense_Mutation_p.R534C	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	549					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						TGCAGAGATTCGCTACCATCG	0.453000													31	57					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648300	112648300	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112648300G>A	ENST00000471858.1	-	3	420	c.188C>T	c.(187-189)cCt>cTt	p.P63L	CD200R1_ENST00000490004.1_Missense_Mutation_p.P63L|CD200R1_ENST00000308611.3_Missense_Mutation_p.P86L|CD200R1_ENST00000440122.2_Missense_Mutation_p.P86L|CD200R1_ENST00000295863.4_Missense_Mutation_p.P41L	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	63	Ig-like V-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TAATGCGATAGGAGGGCAACA	0.383000													23	105					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751819	26751819	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:26751819C>T	ENST00000396641.2	+	2	1248	c.656C>T	c.(655-657)tCa>tTa	p.S219L	LRRC3B_ENST00000417744.1_Missense_Mutation_p.S219L|LRRC3B_ENST00000456208.2_Missense_Mutation_p.S219L	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	219						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						ATGGTGATCTCATATGTGGTA	0.468000													11	30					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2020459	2020459	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2020459C>T	ENST00000262113.4	+	9	969	c.828C>T	c.(826-828)ttC>ttT	p.F276F	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	276	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		ACACGCACTTCGACGTCCAGT	0.567000													8	57					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123369776	123369776	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:123369776C>T	ENST00000275162.4	+	4	1909	c.574C>T	c.(574-576)Cca>Tca	p.P192S	CLVS2_ENST00000368438.1_Missense_Mutation_p.P46S	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	192	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						GGATAGTTTCCCAGCGCGATT	0.378000													23	62					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200965372	200965372	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200965372C>T	ENST00000332129.2	-	15	2545	c.2229G>A	c.(2227-2229)agG>agA	p.R743R	KIF21B_ENST00000461742.2_Silent_p.R743R|KIF21B_ENST00000360529.5_Silent_p.R743R|KIF21B_ENST00000422435.2_Silent_p.R743R	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	743					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TCTTCAGCTCCCTCTCGTAGC	0.612000													74	204					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402151	89402151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89402151G>A	ENST00000439576.2	+	12	6709	c.6335G>A	c.(6334-6336)gGg>gAg	p.G2112E	ACAN_ENST00000559004.1_Missense_Mutation_p.G2112E|ACAN_ENST00000561243.1_Missense_Mutation_p.G2112E|ACAN_ENST00000352105.7_Missense_Mutation_p.G2112E	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2112					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCTGGGTTCGGGGCATCTGCC	0.552000													21	80					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103897786	103897786	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103897786C>T	ENST00000278070.2	+	2	372	c.333C>T	c.(331-333)agC>agT	p.S111S	PPRC1_ENST00000413464.2_Silent_p.S111S	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	111					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		ATTTTGGGAGCCTTGGAGAGG	0.527000													18	32					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130220636	130220636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130220636G>A	ENST00000276211.5	+	11	1828	c.1483G>A	c.(1483-1485)Gaa>Aaa	p.E495K	ARHGAP36_ENST00000370921.1_Missense_Mutation_p.E359K|ARHGAP36_ENST00000370922.1_Missense_Mutation_p.E483K	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	495					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GCCTTCTGATGAAGGTCAGTT	0.537000													20	19					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179580269	179580269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179580269G>A	ENST00000589042.1	-	89	26096	c.25872C>T	c.(25870-25872)gcC>gcT	p.A8624A	TTN_ENST00000342992.6_Silent_p.A7380A|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.A8307A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8307	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCATTGTGGGCCTCACAGG	0.478000													5	78					0	0	1	0	0
MYOZ2	51778	broad.mit.edu	37	4	120085516	120085516	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:120085516A>T	ENST00000307128.5	+	5	740	c.527A>T	c.(526-528)aAg>aTg	p.K176M		NM_016599.4	NP_057683.1	Q9NPC6	MYOZ2_HUMAN	myozenin 2	176							protein phosphatase 2B binding			endometrium(1)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						CCTGAAGGAAAGGCAGAACTG	0.423000													27	76					0	0	1	0	0
SERINC5	256987	broad.mit.edu	37	5	79498730	79498730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79498730G>A	ENST00000507668.2	-	2	320	c.170C>T	c.(169-171)aCc>aTc	p.T57I	SERINC5_ENST00000512972.2_Missense_Mutation_p.T57I|SERINC5_ENST00000513907.1_5'UTR|SERINC5_ENST00000512721.1_Missense_Mutation_p.T57I|SERINC5_ENST00000509193.1_Missense_Mutation_p.T57I	NM_001174071.1|NM_178276.5	NP_001167542.1|NP_840060.1	Q86VE9	SERC5_HUMAN	serine incorporator 5	57					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|kidney(1)|lung(3)|ovary(1)	8		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		GTGAGCCACGGTTGTTGACAT	0.502000													10	24					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098412	144098412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:144098412C>T	ENST00000467773.1	-	4	570	c.571G>A	c.(571-573)Gag>Aag	p.E191K	NOBOX_ENST00000223140.5_Missense_Mutation_p.E106K|NOBOX_ENST00000483238.1_Missense_Mutation_p.E191K	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	191					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					ATCTTCACCTCTCCCACTGGG	0.607000													9	12					0	0	1	0	0
OR8K5	219453	broad.mit.edu	37	11	55926894	55926894	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55926894G>T	ENST00000313447.1	-	1	899	c.900C>A	c.(898-900)gcC>gcA	p.A300A		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GCTTATAGAAGGCATTTTTCA	0.279000													13	70					3.27435e-08	3.28506e-08	1	1	0
C2CD2	25966	broad.mit.edu	37	21	43332497	43332497	+	Silent	SNP	G	G	A	rs139545553	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43332497G>A	ENST00000380486.3	-	7	1138	c.897C>T	c.(895-897)ttC>ttT	p.F299F	C2CD2_ENST00000329623.7_Silent_p.F144F	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	299	C2.					cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						GGGTGCTGGAGAACCTCTGAA	0.498000													11	12					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76451897	76451897	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76451897C>T	ENST00000389840.5	-	63	10081	c.9957G>A	c.(9955-9957)tcG>tcA	p.S3319S	DNAH17_ENST00000585328.1_Silent_p.S3328S|DNAH17_ENST00000586052.1_Intron					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGATGTTTTCCGATGCTAATC	0.557000													8	35					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75550745	75550745	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75550745C>T	ENST00000604729.1	+	8	1251	c.954C>T	c.(952-954)tcC>tcT	p.S318S	ZSWIM8_ENST00000605216.1_Silent_p.S318S|ZSWIM8_ENST00000603114.1_Silent_p.S318S|ZSWIM8_ENST00000604524.1_Silent_p.S318S|ZSWIM8_ENST00000398706.2_Silent_p.S318S					zinc finger, SWIM-type containing 8																		ATGTGAACTCCATGTATCTGT	0.542000													24	64					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128786428	128786428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128786428C>T	ENST00000529694.1	+	3	1438	c.1062C>T	c.(1060-1062)acC>acT	p.T354T	KCNJ5_ENST00000338350.4_Silent_p.T354T|KCNJ5_ENST00000533599.1_Silent_p.T354T	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	354					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	TCCATGATACCTATGAGACCA	0.577000													51	131					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976471	38976471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38976471C>T	ENST00000355481.4	+	34	5307	c.5176C>T	c.(5176-5178)Cgc>Tgc	p.R1726C	RYR1_ENST00000360985.3_Missense_Mutation_p.R1726C|RYR1_ENST00000359596.3_Missense_Mutation_p.R1726C	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1726	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTGCCGCAGCCGCCGCTCCAT	0.647000													33	69					0	0	1	0	0
HPN	3249	broad.mit.edu	37	19	35556465	35556465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35556465G>A	ENST00000262626.2	+	11	1755	c.930G>A	c.(928-930)caG>caA	p.Q310Q	HPN-AS1_ENST00000392227.2_RNA|HPN_ENST00000597419.1_Silent_p.Q152Q|HPN_ENST00000392226.1_Silent_p.Q310Q	NM_182983.2	NP_892028.1	P05981	HEPS_HUMAN	hepsin	310	Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	19	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	GGGTACTCCAGGAGGCTCGAG	0.612000													17	29					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24537774	24537774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:24537774C>T	ENST00000264463.4	-	3	748	c.241G>A	c.(241-243)Gac>Aac	p.D81N		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	81	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TTATCTTGGTCTGAATGTAGC	0.368000										HNSCC(23;0.051)			11	50					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093784	30093784	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30093784C>T	ENST00000567636.1	+	0	2159					NR_003558.1																						GGCCTCTGTTCACAACAGTAG	0.413000													4	11					0	0	1	0	0
LARP1	23367	broad.mit.edu	37	5	154183798	154183798	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154183798C>T	ENST00000336314.4	+	14	2270	c.2246C>T	c.(2245-2247)cCa>cTa	p.P749L		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	826							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGTTCAAACCCACCCTTGGAG	0.532000													42	117					0	0	1	0	0
SEC24B-AS1	100533182	broad.mit.edu	37	4	110268668	110268668	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110268668C>A	ENST00000499713.2	-	0	1395																											ATTCAAGCTCCAACGAGCTTG	0.527000													11	25					6.40141e-05	6.41263e-05	1	1	0
DTWD2	285605	broad.mit.edu	37	5	118176751	118176751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:118176751G>A	ENST00000304058.4	-	6	630	c.560C>T	c.(559-561)tCc>tTc	p.S187F	DTWD2_ENST00000510708.1_Missense_Mutation_p.S253F|DTWD2_ENST00000515439.3_Missense_Mutation_p.S157F			Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	253										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)	13		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		AAGTTGAAAGGAGCATAAAGC	0.373000													9	19					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43319611	43319611	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43319611C>T	ENST00000589700.1	+	5	782	c.782C>T	c.(781-783)tCc>tTc	p.S261F	SLC14A1_ENST00000502059.2_Silent_p.L202L|SLC14A1_ENST00000586142.1_Silent_p.L310L|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000436407.3_Silent_p.L366L|SLC14A1_ENST00000591541.1_Silent_p.L14L|SLC14A1_ENST00000402943.2_Silent_p.L205L|RP11-116O18.3_ENST00000586213.1_RNA|SLC14A1_ENST00000535474.1_Silent_p.L178L|SLC14A1_ENST00000321925.4_Silent_p.L310L|SLC14A1_ENST00000415427.3_Silent_p.L366L			Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	0						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						AAACCCACCTCCTGGCTCTTG	0.537000													28	69					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21695445	21695445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21695445C>T	ENST00000261195.2	-	13	1884	c.1630G>A	c.(1630-1632)Gat>Aat	p.D544N		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	544					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GCAGTAGGATCAGCCACGTGC	0.507000													10	38					0	0	1	0	0
SEC24B	10427	broad.mit.edu	37	4	110447439	110447439	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110447439C>T	ENST00000265175.5	+	17	2904	c.2849C>T	c.(2848-2850)tCc>tTc	p.S950F	SEC24B_ENST00000399100.2_Missense_Mutation_p.S915F|SEC24B_ENST00000504968.2_Missense_Mutation_p.S980F	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	950					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		GATTTGTTATCCCTTGCCAAC	0.348000													39	88					0	0	1	0	0
PAPOLG	64895	broad.mit.edu	37	2	60995608	60995608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:60995608C>T	ENST00000238714.3	+	4	499	c.250C>T	c.(250-252)Ctc>Ttc	p.L84F		NM_022894.3	NP_075045.2	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	84					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	35	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			ATTTTAGAACCTCCCACCTTC	0.383000													10	109					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3806148	3806148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:3806148C>T	ENST00000440314.2	-	4	491	c.18G>A	c.(16-18)ggG>ggA	p.G6G	EFCAB4B_ENST00000444507.1_Silent_p.G6G|EFCAB4B_ENST00000252322.1_Silent_p.G6G	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	6					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			AGACTACCCTCCCGTCAGGGG	0.572000													10	16					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628811	84628811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:84628811C>T	ENST00000284136.6	-	17	2322	c.2279G>A	c.(2278-2280)cGa>cAa	p.R760Q	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	760	Arg/Lys-rich (basic).				cell differentiation|nervous system development	extracellular region|membrane	receptor activity	p.R760Q(1)		NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TCTTCGATTTCGTTTCTTCTT	0.453000													32	78					0	0	1	0	0
DTNB	1838	broad.mit.edu	37	2	25678335	25678335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:25678335G>A	ENST00000406818.3	-	11	1357	c.1108C>T	c.(1108-1110)Cac>Tac	p.H370Y	DTNB_ENST00000405222.1_Intron|DTNB_ENST00000407186.1_Intron|DTNB_ENST00000496972.2_Missense_Mutation_p.H313Y|DTNB_ENST00000404103.3_Missense_Mutation_p.H370Y|DTNB_ENST00000407038.3_Intron|DTNB_ENST00000545439.1_Missense_Mutation_p.H166Y|DTNB_ENST00000407661.3_Missense_Mutation_p.H370Y|DTNB_ENST00000288642.8_Missense_Mutation_p.H370Y	NM_001256303.1|NM_021907.4	NP_001243232.1|NP_068707.1	O60941	DTNB_HUMAN	dystrobrevin, beta	370						cytoplasm	calcium ion binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGGCCAAGTGACTGGGTATA	0.527000													6	11					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157516898	157516898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157516898G>A	ENST00000361835.3	-	3	299	c.142C>T	c.(142-144)Cgc>Tgc	p.R48C	FCRL5_ENST00000356953.4_Missense_Mutation_p.R48C|FCRL5_ENST00000368188.2_Missense_Mutation_p.R48C|FCRL5_ENST00000368190.3_Missense_Mutation_p.R48C|FCRL5_ENST00000368189.3_Missense_Mutation_p.R48C|FCRL5_ENST00000368191.3_Intron	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	48	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity	p.R48C(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GAGTAGAAGCGAAATCCCTTG	0.478000													35	96					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196309524	196309524	+	Missense_Mutation	SNP	G	G	A	rs140538298		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196309524G>A	ENST00000367433.5	-	16	1831	c.1730C>T	c.(1729-1731)tCg>tTg	p.S577L	KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Missense_Mutation_p.S188L|KCNT2_ENST00000367431.4_Missense_Mutation_p.S527L|KCNT2_ENST00000294725.8_Missense_Mutation_p.S577L			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	577						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						ATGATAAAACGACCTGGACAC	0.303000													30	106					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80048890	80048890	+	Silent	SNP	G	G	A	rs145311183		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80048890G>A	ENST00000306749.2	-	10	1766	c.1548C>T	c.(1546-1548)ttC>ttT	p.F516F		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	516	Acyl and malonyl transferases (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TGGAATCTCGGAAGCGGTCCA	0.622000													19	57					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46326989	46326989	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46326989G>A	ENST00000397850.2	-	5	621	c.169C>T	c.(169-171)Cct>Tct	p.P57S	ITGB2_ENST00000397852.1_Missense_Mutation_p.P57S|ITGB2_ENST00000302347.5_Missense_Mutation_p.P57S|ITGB2_ENST00000397857.1_Missense_Mutation_p.P57S|ITGB2_ENST00000355153.4_Missense_Mutation_p.P57S|ITGB2_ENST00000397854.3_Missense_Mutation_p.P57S			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	57					apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	ATGGAGTCAGGATCCCCCGGC	0.652000													15	42					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41961632	41961632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41961632G>A	ENST00000298919.7	+	9	1123	c.735G>A	c.(733-735)gaG>gaA	p.E245E	PDZRN4_ENST00000402685.2_Silent_p.E505E|PDZRN4_ENST00000539469.2_Silent_p.E247E			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	505	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCTTAGAGGAGTTAAACTTGG	0.398000													17	77					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8399573	8399573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8399573G>A	ENST00000471889.1	+	8	2180	c.1795G>A	c.(1795-1797)Gag>Aag	p.E599K	SLC45A1_ENST00000377479.2_Missense_Mutation_p.E633K|SLC45A1_ENST00000289877.8_Missense_Mutation_p.E599K			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	599					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGCTGGAGGAGTTCCTCAG	0.652000													20	72					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41165887	41165887	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41165887G>A	ENST00000483722.1	-	2	521	c.336C>T	c.(334-336)atC>atT	p.I112I		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	112	Ig-like V-type.				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGGGGTACAGGATCCCAGAGG	0.622000													9	39					0	0	1	0	0
FAM86EP	348926	broad.mit.edu	37	4	3949503	3949503	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3949503G>A	ENST00000281228.8	-	0	706				FAM86EP_ENST00000313946.8_RNA																							GGACGGCAGAGAGCTGACAGA	0.607000													4	36					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179503926	179503926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179503926C>T	ENST00000367618.3	+	25	3247	c.2860C>T	c.(2860-2862)Cat>Tat	p.H954Y		NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	954	Glu-rich.									NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						TGAGAAACTTCATCATACCCT	0.348000													36	107					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102316	168102316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168102316G>A	ENST00000409195.1	+	9	4503	c.4414G>A	c.(4414-4416)Gaa>Aaa	p.E1472K	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1472K|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1250K	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1297					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GTTAGAATATGAAAATATCAA	0.378000													31	85					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44595350	44595350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44595350G>A	ENST00000372299.3	+	2	465	c.407G>A	c.(406-408)gGa>gAa	p.G136E	KLF17_ENST00000476802.1_Intron	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	136					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					ATGCCCGTAGGAGAGCCCAAT	0.542000													36	58					0	0	1	0	0
KRT72	140807	broad.mit.edu	37	12	52979922	52979922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52979922C>T	ENST00000293745.2	-	9	1465	c.1380G>A	c.(1378-1380)ggG>ggA	p.G460G	KRT72_ENST00000354310.4_Silent_p.G418G|KRT72_ENST00000537672.2_Silent_p.G460G|KRT72_ENST00000398066.3_Silent_p.G272G	NM_080747.2	NP_542785.1	Q14CN4	K2C72_HUMAN	keratin 72	460	Tail.					keratin filament	structural molecule activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(357;0.195)		TGAAGCCAGCCCCTCCTGCCC	0.587000													9	46					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108147413	108147413	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108147413C>T	ENST00000273353.3	-	28	3744	c.3688G>A	c.(3688-3690)Gaa>Aaa	p.E1230K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1230						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TTGTCTTTTTCCAGTTTCTGC	0.488000													55	105					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207528044	207528044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207528044C>T	ENST00000452335.2	-	11	1332	c.1216G>A	c.(1216-1218)Gaa>Aaa	p.E406K		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	406						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		GGAACCTTTTCAGTTGAAGAA	0.448000													22	60					0	0	1	0	0
MRPL44	65080	broad.mit.edu	37	2	224824592	224824592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:224824592C>T	ENST00000258383.3	+	2	590	c.521C>T	c.(520-522)gCt>gTt	p.A174V		NM_022915.3	NP_075066.1	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44	174	RNase III.				RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		AGAAACTTGGCTGTGGAGCAG	0.483000													28	112					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15726582	15726582	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15726582C>T	ENST00000441682.2	+	0	219							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CGGTGTTTCCCGCAGCCCCGG	0.642000													8	118					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230471	140230471	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140230471G>A	ENST00000378122.3	+	1	3115	c.2391G>A	c.(2389-2391)ggG>ggA	p.G797G	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Silent_p.G797G|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCAACTGGGAAGGTGGGTT	0.423000													33	26					0	0	1	0	0
HBG2	3048	broad.mit.edu	37	11	5275566	5275566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5275566C>T	ENST00000380259.2	-	7	1511	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K	HBG2_ENST00000336906.4_Missense_Mutation_p.E91K|HBG2_ENST00000380252.1_Missense_Mutation_p.E81K					hemoglobin, gamma G											endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	13		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGTGCAGTTCACTCAGCTGG	0.507000													28	130					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19492695	19492695	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19492695C>T	ENST00000396229.2	+	15	3020	c.2271C>T	c.(2269-2271)atC>atT	p.I757I	TMC5_ENST00000542583.2_Silent_p.I757I|TMC5_ENST00000564959.1_Silent_p.I440I|TMC5_ENST00000561503.1_Silent_p.I398I|CTA-363E6.6_ENST00000561762.1_RNA|TMC5_ENST00000219821.5_Silent_p.I511I|TMC5_ENST00000541464.1_Silent_p.I705I|TMC5_ENST00000381414.4_Silent_p.I757I	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	757						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TTCACAGAATCATTGGGATGC	0.443000													12	89					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55761311	55761311	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55761311G>A	ENST00000278409.1	-	1	790	c.791C>T	c.(790-792)tCc>tTc	p.S264F		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					GGAGTAGCTGGAACTAGGTCT	0.498000													32	81					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53190843	53190843	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:53190843T>G	ENST00000566029.1	+	2	1051	c.842T>G	c.(841-843)aTa>aGa	p.I281R	CHD9_ENST00000564845.1_Missense_Mutation_p.I281R|CHD9_ENST00000447540.1_Missense_Mutation_p.I281R|CHD9_ENST00000398510.3_Missense_Mutation_p.I281R			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	281	Ser-rich.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				AGTAATCATATATCACCAAAC	0.343000													36	78					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941152	144941152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144941152C>T	ENST00000525985.1	-	2	6341	c.6270G>A	c.(6268-6270)cgG>cgA	p.R2090R				P58107	EPIPL_HUMAN	epiplakin 1	2090						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTCGGAGTCCCGTGCAGCCT	0.597000													14	121					0	0	1	0	0
GCK	2645	broad.mit.edu	37	7	44189392	44189392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44189392C>T	ENST00000403799.3	-	6	1115	c.646G>A	c.(646-648)Gaa>Aaa	p.E216K	GCK_ENST00000437084.1_Missense_Mutation_p.E199K|GCK_ENST00000395796.3_Missense_Mutation_p.E215K|GCK_ENST00000345378.2_Missense_Mutation_p.E217K	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	216					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						TGATGGTCTTCGTAGTAGCAG	0.557000													40	81					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28761201	28761201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:28761201G>A	ENST00000422425.2	+	10	648	c.604G>A	c.(604-606)Ggc>Agc	p.G202S	PLB1_ENST00000327757.5_Missense_Mutation_p.G191S	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	191	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GCTTGCGGCGGGCGGCGTGGA	0.652000													13	21					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120148155	120148155	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120148155G>A	ENST00000392521.2	-	39	5027	c.4972C>T	c.(4972-4974)Ctg>Ttg	p.L1658L	CIT_ENST00000261833.7_Silent_p.L1616L|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1616	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		AAGACATTCAGGGCGTAGAGC	0.498000													44	66					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11728976	11728976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11728976G>A	ENST00000381486.2	+	10	1564	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	GREB1_ENST00000234142.5_Missense_Mutation_p.E422K|GREB1_ENST00000381483.2_Missense_Mutation_p.E422K	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	422						integral to membrane		p.E422K(2)		breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ACGGGCATACGAGCAGTACGG	0.587000													43	88					0	0	1	0	0
RP11-909M7.3	0	broad.mit.edu	37	14	101450256	101450256	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101450256G>A	ENST00000554693.2	+	0	799				SNORD114-23_ENST00000363536.1_RNA																							CATAGACAATGAATACGTGTC	0.358000													62	197					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16339673	16339673	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:16339673G>A	ENST00000400202.1	-	3	1553	c.841C>T	c.(841-843)Cga>Tga	p.R281*	NRIP1_ENST00000400199.1_Nonsense_Mutation_p.R281*|NRIP1_ENST00000318948.4_Nonsense_Mutation_p.R281*			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	281	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GCGTGTTCTCGAGAATACTGC	0.458000													33	101					0	0	1	0	0
COMMD1	150684	broad.mit.edu	37	2	62132963	62132963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:62132963C>T	ENST00000311832.5	+	1	182	c.150C>T	c.(148-150)ccC>ccT	p.P50P	COMMD1_ENST00000538736.1_Silent_p.P50P|COMMD1_ENST00000472729.1_Intron	NM_152516.2	NP_689729.1	Q8N668	COMD1_HUMAN	copper metabolism (Murr1) domain containing 1	50					copper ion homeostasis|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process	cell junction|Cul2-RING ubiquitin ligase complex|cytoplasm|nucleolus	copper ion binding|protein homodimerization activity			large_intestine(1)|liver(2)|lung(5)|ovary(1)	9	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;4.73e-07)|Epithelial(17;0.0216)|all cancers(80;0.0934)			AGTTCCGCCCCTTTCTGGCAA	0.597000													12	48					0	0	1	0	0
PARP1	142	broad.mit.edu	37	1	226570804	226570804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226570804G>A	ENST00000366794.5	-	8	1235	c.1092C>T	c.(1090-1092)tcC>tcT	p.S364S		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	364					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TGGCCGCCACGGAGGCGCTGG	0.512000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					85	280					0	0	1	0	0
GLYR1	84656	broad.mit.edu	37	16	4881996	4881996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4881996G>A	ENST00000321919.9	-	5	597	c.521C>T	c.(520-522)cCc>cTc	p.P174L	GLYR1_ENST00000381983.3_Missense_Mutation_p.P174L|GLYR1_ENST00000436648.5_Intron|GLYR1_ENST00000591451.1_Missense_Mutation_p.P174L|GLYR1_ENST00000586901.1_5'UTR	NM_032569.3	NP_115958.2	Q49A26	GLYR1_HUMAN	glyoxylate reductase 1 homolog (Arabidopsis)	174					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	19						ATCCTTTGGGGGCCGACCCCG	0.498000													19	47					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313882	54313882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54313882G>A	ENST00000324134.6	-	3	1199	c.1031C>T	c.(1030-1032)cCc>cTc	p.P344L	NLRP12_ENST00000391772.1_Missense_Mutation_p.P344L|NLRP12_ENST00000535162.1_Missense_Mutation_p.P344L|NLRP12_ENST00000391773.1_Missense_Mutation_p.P344L|NLRP12_ENST00000354278.3_Missense_Mutation_p.P344L|NLRP12_ENST00000391775.3_Missense_Mutation_p.P344L|NLRP12_ENST00000351894.4_Missense_Mutation_p.P344L|NLRP12_ENST00000345770.5_Missense_Mutation_p.P344L	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	344	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAAAGCCGTGGGCCGTGTGGT	0.547000													48	118					0	0	1	0	0
LARGE	9215	broad.mit.edu	37	22	34000534	34000534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:34000534G>A	ENST00000354992.2	-	6	1073	c.502C>T	c.(502-504)Ctg>Ttg	p.L168L	LARGE_ENST00000397394.2_Silent_p.L168L|LARGE_ENST00000337431.2_Silent_p.L168L|LARGE_ENST00000402320.1_Silent_p.L168L|LARGE_ENST00000437602.2_Silent_p.L168L	NM_004737.4	NP_004728.1	O95461	LARGE_HUMAN	like-glycosyltransferase	168					glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(1;0.219)				TGGAAGTGCAGAGGGTTCCGT	0.547000													18	62					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94888377	94888377	+	Missense_Mutation	SNP	G	G	A	rs139457907		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94888377G>A	ENST00000357742.4	+	7	989	c.989G>A	c.(988-990)cGa>cAa	p.R330Q	MCTP2_ENST00000543482.1_Missense_Mutation_p.R330Q|MCTP2_ENST00000451018.3_Missense_Mutation_p.R330Q|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	330					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AATCGGAAGCGATTAAGTGCC	0.318000													6	63					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43552380	43552380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43552380C>T	ENST00000220420.5	-	3	313	c.306G>A	c.(304-306)gtG>gtA	p.V102V	TGM5_ENST00000349114.4_Intron	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	102					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CGCACAAGCTCACCTCTGTGG	0.642000													28	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179638073	179638073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179638073G>A	ENST00000589042.1	-	33	7842	c.7618C>T	c.(7618-7620)Cgt>Tgt	p.R2540C	TTN_ENST00000342992.6_Missense_Mutation_p.R2540C|TTN_ENST00000360870.5_Missense_Mutation_p.R2540C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R2494C|TTN_ENST00000342175.6_Missense_Mutation_p.R2494C|TTN_ENST00000359218.5_Missense_Mutation_p.R2494C|TTN_ENST00000591111.1_Missense_Mutation_p.R2540C|TTN-AS1_ENST00000584485.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2274							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R2494C(3)|p.R2540C(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAAGGTCACGAAGACCTCTG	0.353000													22	68					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958448	53958448	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53958448C>T	ENST00000454407.1	+	0	1140							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		ACAGCTCACTCTTAAGGAAAC	0.363000													46	169					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69329483	69329483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:69329483C>T	ENST00000260364.5	+	9	1551	c.1250C>T	c.(1249-1251)gCc>gTc	p.A417V	NOX5_ENST00000455873.3_Missense_Mutation_p.A400V|NOX5_ENST00000448182.3_Missense_Mutation_p.A389V|NOX5_ENST00000530406.2_Missense_Mutation_p.A407V|NOX5_ENST00000388866.3_Missense_Mutation_p.A435V			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	435	Ferric oxidoreductase.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CTGGAGAAGGCCATCGGACTG	0.572000													36	98					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13830851	13830851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13830851C>T	ENST00000265104.4	-	36	6020	c.5916G>A	c.(5914-5916)atG>atA	p.M1972I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1972	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCCCCATGCTCATTCCCAGAG	0.512000									Kartagener syndrome				32	74					0	0	1	0	0
NEURL3	93082	broad.mit.edu	37	2	97171064	97171064	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97171064G>A	ENST00000310865.3	-	0	18									neuralized E3 ubiquitin protein ligase 3																		GGTCTAGAAGGAACTGCCTGG	0.522000													14	41					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720829	140720829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140720829G>A	ENST00000394576.2	+	1	2291	c.2291G>A	c.(2290-2292)cGg>cAg	p.R764Q	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGACTCGCGGAAGAGCCAC	0.562000													22	216					0	0	1	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420206	56420206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:56420206G>A	ENST00000407595.2	+	2	1373	c.871G>A	c.(871-873)Gaa>Aaa	p.E291K	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	291	His-rich.									breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGGCAGCCCCGAACAGCAAAG	0.627000													46	114					0	0	1	0	0
TTC39A	22996	broad.mit.edu	37	1	51777827	51777827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:51777827G>A	ENST00000262676.5	-	4	470	c.310C>T	c.(310-312)Ctg>Ttg	p.L104L	TTC39A_ENST00000262675.7_Silent_p.L80L|TTC39A_ENST00000447632.2_Silent_p.L108L|TTC39A_ENST00000451380.1_Silent_p.L107L|TTC39A_ENST00000371747.3_Silent_p.L107L|TTC39A_ENST00000371750.5_Silent_p.L108L|TTC39A_ENST00000413473.2_Silent_p.L111L			Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A	108							binding	p.0?(2)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(2)|prostate(2)|skin(3)|urinary_tract(1)	17						CGGTTCACCAGGCTGCTGAAG	0.567000													4	18					0	0	1	0	0
GSG1L	146395	broad.mit.edu	37	16	27895874	27895874	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27895874G>A	ENST00000380898.2	-	3	567	c.18C>T	c.(16-18)ttC>ttT	p.F6F	GSG1L_ENST00000395724.3_Intron|GSG1L_ENST00000380897.3_Silent_p.F6F|GSG1L_ENST00000447459.2_Silent_p.F161F|GSG1L_ENST00000569166.1_Silent_p.F6F			Q6UXU4	GSG1L_HUMAN	GSG1-like	161						integral to membrane				endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(4)	17						TGCTGGAGTGGAAGAGCTCGA	0.587000													4	14					0	0	1	0	0
ODAM	54959	broad.mit.edu	37	4	71063013	71063013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71063013G>A	ENST00000396094.2	+	3	164	c.116G>A	c.(115-117)gGt>gAt	p.G39D		NM_017855.3	NP_060325.3	A1E959	ODAM_HUMAN	odontogenic, ameloblast asssociated	39					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(3)|skin(2)	20						CTTAATAATGGTCAACTTTTG	0.274000													24	89					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131072886	131072886	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131072886G>A	ENST00000357668.1	-	27	3158	c.3131C>T	c.(3130-3132)tCc>tTc	p.S1044F	ASAP1_ENST00000518721.1_Missense_Mutation_p.S1044F			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	1044					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						GAGGTCGTTGGAGTCTTCAGA	0.532000													26	199					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10363559	10363559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10363559C>T	ENST00000377093.4	+	21	2469	c.2316C>T	c.(2314-2316)gcC>gcT	p.A772A	KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000377083.1_Silent_p.A772A|KIF1B_ENST00000263934.6_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AGCTTTGTGCCATGTATGGCA	0.537000													45	81					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142188379	142188379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142188379C>T	ENST00000350721.4	-	38	6473	c.6352G>A	c.(6352-6354)Gat>Aat	p.D2118N	ATR_ENST00000383101.3_Missense_Mutation_p.D2054N|RP11-383G6.3_ENST00000460977.1_RNA	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2118	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TTACCCAAATCATTCCTCATT	0.343000								Other conserved DNA damage response genes					31	83					0	0	1	0	0
TPM3	7170	broad.mit.edu	37	1	154163758	154163758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154163758C>T	ENST00000368530.2	-	2	339	c.147G>A	c.(145-147)aaG>aaA	p.K49K	TPM3_ENST00000271850.7_Silent_p.K49K	NM_152263.2	NP_689476.2	P06753	TPM3_HUMAN	tropomyosin 3	48					cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/NTRK1_ENST00000392302(70)|TPM3/ALK(33)	breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					CTTTCAGCTTCTTCTGCATGG	0.512000			T	"""NTRK1, ALK, ROS1"""	"""papillary thyroid, ALCL, NSCLC"""								40	76					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806039	54806039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54806039C>T	ENST00000306858.7	+	5	2386	c.2270C>T	c.(2269-2271)tCa>tTa	p.S757L		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	757										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					GAACTTGCTTCAAAGAAGGAA	0.383000													16	57					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58512243	58512243	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58512243G>A	ENST00000302819.5	-	10	1587	c.1296C>T	c.(1294-1296)gcC>gcT	p.A432A	ACOX2_ENST00000459701.2_Silent_p.A418A	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	432					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		AGGTACAGGAGGCCGACAATT	0.607000													22	29					0	0	1	0	0
GPR162	27239	broad.mit.edu	37	12	6936037	6936037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6936037C>T	ENST00000311268.3	+	5	2222	c.1435C>T	c.(1435-1437)Ctt>Ttt	p.L479F	GPR162_ENST00000428545.2_Missense_Mutation_p.L195F|GPR162_ENST00000382315.3_Missense_Mutation_p.L175F	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	479						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						GCTGGCCAGCCTTCGCCAATT	0.642000													28	118					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	12006381	12006381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:12006381C>T	ENST00000396373.4	+	4	623	c.349C>T	c.(349-351)Ctt>Ttt	p.L117F		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	117	PNT.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CTATGAACTCCTTCAGCATAT	0.443000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								45	113					0	0	1	0	0
C4orf45	152940	broad.mit.edu	37	4	159836479	159836479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:159836479C>T	ENST00000434826.2	-	4	473	c.389G>A	c.(388-390)gGa>gAa	p.G130E	C4orf45_ENST00000508011.1_5'UTR	NM_152543.2	NP_689756.2	Q96LM5	CD045_HUMAN	chromosome 4 open reading frame 45	130										large_intestine(2)|lung(3)	5						ACTCTGTTTTCCTTGCATATC	0.433000													8	22					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26718782	26718782	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26718782G>A	ENST00000396005.3	-	8	1278	c.969C>T	c.(967-969)gtC>gtT	p.V323V	SLC5A12_ENST00000280467.6_Silent_p.V323V	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	323					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						ATATCTCCATGACAAAGTACG	0.378000													40	81					0	0	1	0	0
RBBP5	5929	broad.mit.edu	37	1	205069166	205069166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205069166G>A	ENST00000264515.6	-	8	920	c.779C>T	c.(778-780)tCt>tTt	p.S260F	RBBP5_ENST00000367164.1_Missense_Mutation_p.S260F	NM_001193273.1|NM_005057.3	NP_001180202.1|NP_005048.2	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	260					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CCCATCCCCAGAGAAACAACA	0.507000													25	75					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999578	46999578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46999578C>T	ENST00000374314.4	+	1	1653	c.698C>T	c.(697-699)gCt>gTt	p.A233V	GPRIN2_ENST00000374317.1_Missense_Mutation_p.A233V			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	233			A -> S (in dbSNP:rs11204659).							breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						CCCCCAGCTGCTCTACTCTGT	0.632000													5	48					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171227237	171227237	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171227237G>A	ENST00000354841.4	+	1	142	c.11G>A	c.(10-12)cGa>cAa	p.R4Q	FMO1_ENST00000402921.2_Missense_Mutation_p.R4Q|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.R4Q			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	4					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGGCCAAGCGAGTTGCCATT	0.537000													21	52					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	240976925	240976925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240976925C>T	ENST00000366565.1	-	13	1330	c.949G>A	c.(949-951)Gag>Aag	p.E317K	RGS7_ENST00000407727.1_Missense_Mutation_p.E317K|RGS7_ENST00000401882.1_Missense_Mutation_p.E264K|RGS7_ENST00000348120.2_Missense_Mutation_p.E264K|RGS7_ENST00000366562.4_Missense_Mutation_p.E317K|RGS7_ENST00000366563.1_Missense_Mutation_p.E317K|RGS7_ENST00000366564.1_Missense_Mutation_p.E317K|RGS7_ENST00000331110.7_Missense_Mutation_p.E291K|RGS7_ENST00000446183.2_Missense_Mutation_p.E233K	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	317					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TACCTTGCCTCAAGTTCCCAG	0.433000													15	35					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184298852	184298852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184298852G>A	ENST00000330394.2	+	14	3083	c.2631G>A	c.(2629-2631)cgG>cgA	p.R877R	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	877	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCTGGGTGCGGGACCGGAACC	0.602000													28	86					0	0	1	0	0
NOX1	27035	broad.mit.edu	37	X	100117458	100117458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:100117458C>T	ENST00000372966.3	-	6	799	c.594G>A	c.(592-594)agG>agA	p.R198R	NOX1_ENST00000217885.5_Silent_p.R198R|NOX1_ENST00000372960.4_Silent_p.R161R|NOX1_ENST00000372964.1_Intron	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	198	Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						CAAAATAACTCCTCCGGATGA	0.438000													114	68					0	0	1	0	0
NLGN3	54413	broad.mit.edu	37	X	70387219	70387219	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70387219C>T	ENST00000374051.3	+	6	1534	c.1212C>T	c.(1210-1212)gtC>gtT	p.V404V	NLGN3_ENST00000536169.1_Silent_p.V384V|NLGN3_ENST00000358741.3_Silent_p.V424V|NLGN3_ENST00000476589.1_3'UTR	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	424					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					AGGATGGTGTCTCTGGCACTG	0.517000													31	20					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79387439	79387439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79387439C>T	ENST00000264895.6	+	50	7547	c.7107C>T	c.(7105-7107)ttC>ttT	p.F2369F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2368					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GGCAGCATTTCCACCTCACCT	0.557000													22	74					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971644	96971644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96971644G>A	ENST00000341686.3	+	6	890	c.765G>A	c.(763-765)atG>atA	p.M255I	C10orf129_ENST00000430183.1_Missense_Mutation_p.M100I|C10orf129_ENST00000394005.3_Missense_Mutation_p.M255I	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	255					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GACGGTGGATGGATCTCCAGC	0.483000													12	42					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101510475	101510475	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101510475G>A	ENST00000392979.3	+	24	2725	c.2364G>A	c.(2362-2364)gtG>gtA	p.V788V	ANO4_ENST00000550015.1_Silent_p.V343V|ANO4_ENST00000392977.3_Silent_p.V823V|ANO4_ENST00000299222.9_Silent_p.V343V	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	823						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TTGGCTATGTGAATGCCAGCT	0.473000										HNSCC(74;0.22)			79	207					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60591609	60591609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:60591609C>T	ENST00000406854.1	+	9	3274	c.2720C>T	c.(2719-2721)tCt>tTt	p.S907F	PCNXL4_ENST00000535349.1_Missense_Mutation_p.S114F|PCNXL4_ENST00000406949.1_Missense_Mutation_p.S673F|PCNXL4_ENST00000404681.2_Missense_Mutation_p.S907F|PCNXL4_ENST00000317623.4_Missense_Mutation_p.S673F					pecanex-like 4 (Drosophila)																		TGTTCACATTCTCACTTAGTA	0.423000													11	167					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882500	228882500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228882500C>T	ENST00000392056.3	-	7	3116	c.3070G>A	c.(3070-3072)Gag>Aag	p.E1024K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E1024K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1024						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCATGGACTCATCCACAACC	0.498000													30	120					0	0	1	0	0
PNMA5	114824	broad.mit.edu	37	X	152159171	152159171	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:152159171G>A	ENST00000439251.1	-	2	1410	c.972C>T	c.(970-972)ctC>ctT	p.L324L	PNMA5_ENST00000361887.5_Silent_p.L324L|PNMA5_ENST00000535214.1_Silent_p.L324L|PNMA5_ENST00000452693.1_Silent_p.L324L	NM_001103150.1	NP_001096620.1	Q96PV4	PNMA5_HUMAN	paraneoplastic Ma antigen family member 5	324					apoptosis			p.L324L(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					CATCTCGAATGAGCTTCATTA	0.562000													23	26					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78071191	78071191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78071191C>T	ENST00000397545.4	+	19	3196	c.3169C>T	c.(3169-3171)Ctc>Ttc	p.L1057F		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1057					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTTGGGGCCCTCAAACGACA	0.592000													10	39					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44234833	44234833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:44234833G>A	ENST00000330884.4	-	4	542	c.422C>T	c.(421-423)tCt>tTt	p.S141F	SULT4A1_ENST00000249130.5_Missense_Mutation_p.S141F|SULT4A1_ENST00000540422.1_Intron	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	141					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		CTGATAATAAGACACCACCAG	0.552000													21	59					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25014056	25014056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25014056C>T	ENST00000382114.4	-	7	906	c.721G>A	c.(721-723)Gat>Aat	p.D241N		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	241						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				ACGTACACATCGTTCTTGGAG	0.468000													26	84					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17190305	17190305	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17190305A>G	ENST00000265970.7	-	1	983	c.984T>C	c.(982-984)ctT>ctC	p.L328L	PIK3C2A_ENST00000540361.1_Intron|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	328					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	TTGCCACAGAAAGGGATTTTC	0.398000													32	163					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8590392	8590392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8590392G>A	ENST00000338257.8	-	25	3092	c.2825C>T	c.(2824-2826)cCt>cTt	p.P942L		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	942						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CGCCCGGGTAGGGGCTTGGGA	0.607000													29	43					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2855543	2855543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2855543G>A	ENST00000520002.1	-	55	8925	c.8370C>T	c.(8368-8370)ccC>ccT	p.P2790P	CSMD1_ENST00000542608.1_Silent_p.P2731P|CSMD1_ENST00000537824.1_Silent_p.P2789P|CSMD1_ENST00000602723.1_Silent_p.P2732P|CSMD1_ENST00000400186.3_Silent_p.P2732P|CSMD1_ENST00000602557.1_Silent_p.P2790P			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2790	Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCGACACGTGGGCAGAGGGC	0.547000													9	29					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237604620	237604620	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237604620A>G	ENST00000366574.2	+	13	1324	c.1005_splice	c.e13-1	p.E336_splice	RYR2_ENST00000360064.6_Splice_Site_p.E334_splice|RYR2_ENST00000542537.1_Splice_Site_p.E320_splice	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	336	MIR 4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCCCCTTAGGAAAAATTGGAT	0.358000													24	55					0	0	1	0	0
TMCO4	255104	broad.mit.edu	37	1	20107106	20107106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:20107106G>A	ENST00000294543.6	-	4	387	c.146C>T	c.(145-147)tCc>tTc	p.S49F	TMCO4_ENST00000375122.2_Missense_Mutation_p.S49F|TMCO4_ENST00000375127.1_Missense_Mutation_p.S49F	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	49						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		CTGGGACAGGGAGATGCCACA	0.592000													15	33					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12856867	12856867	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12856867G>A	ENST00000456430.2	+	8	1275	c.1234G>A	c.(1234-1236)Gga>Aga	p.G412R	CAND2_ENST00000295989.5_Missense_Mutation_p.G319R	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	412					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GCCCCCGAAGGGATGGCTGGA	0.612000													23	62					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89265995	89265995	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89265995C>T	ENST00000464162.1	-	0	165																											CTGACTTGCCCGGCAAGTGAT	0.502000													59	202					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103142729	103142729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103142729G>A	ENST00000295269.4	+	11	2419	c.1962G>A	c.(1960-1962)aaG>aaA	p.K654K		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	654					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CTGGCACCAAGAATATCCGCT	0.517000													41	114					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131519662	131519662	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131519662G>A	ENST00000423981.1	+	2	127	c.17G>A	c.(16-18)gGa>gAa	p.G6E	AMER3_ENST00000321420.4_Missense_Mutation_p.G6E	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		CTGAAGAGAGGAAAGACCTTC	0.622000													3	16					0	0	1	0	0
CIDEA	1149	broad.mit.edu	37	18	12277269	12277269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:12277269G>A	ENST00000320477.9	+	5	725	c.660G>A	c.(658-660)taG>taA	p.*220*	CIDEA_ENST00000521296.1_3'UTR	NM_001279.3	NP_001270.1	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a	0					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)	13						CGTGTGGATAGGGATGCAGGC	0.527000													25	29					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75514208	75514208	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75514208G>A	ENST00000355774.2	-	2	2366	c.2151C>T	c.(2149-2151)ttC>ttT	p.F717F	MLH3_ENST00000556257.1_Silent_p.F717F|MLH3_ENST00000380968.2_5'UTR|MLH3_ENST00000556740.1_Silent_p.F717F|MLH3_ENST00000238662.7_Silent_p.F717F	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	717					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TATACCAGGGGAAAGAGGGGG	0.378000								Mismatch excision repair (MMR)					39	99					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143986231	143986231	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:143986231C>T	ENST00000409869.1	+	6	555	c.378C>T	c.(376-378)tcC>tcT	p.S126S	ARHGAP15_ENST00000295095.6_Silent_p.S126S			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	126	PH.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		AGGCTCTGTCCAATATGGTAA	0.303000													34	58					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413680	178413680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178413680C>T	ENST00000231188.5	-	8	1753	c.1575G>A	c.(1573-1575)ggG>ggA	p.G525G	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Silent_p.G525G	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	525					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		TCTTCCGCTCCCCCGGCCCGC	0.672000													13	46					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846459	43846459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43846459C>T	ENST00000389420.3	-	13	1799	c.1800G>A	c.(1798-1800)atG>atA	p.M600I	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.M600I	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	600	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ATCGAAATTTCATCCTGCGGC	0.388000													10	17					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176738894	176738894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176738894C>T	ENST00000367662.3	+	16	5639	c.4475C>T	c.(4474-4476)tCt>tTt	p.S1492F		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1492	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGCTCAATCTCTTGTGTCCCA	0.522000													52	106					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19317917	19317917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:19317917C>T	ENST00000461366.1	+	9	1167	c.952C>T	c.(952-954)Cgt>Tgt	p.R318C		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	318							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						CCTCTTAGTTCGTGACTCATC	0.597000													19	26					0	0	1	0	0
HFE2	148738	broad.mit.edu	37	1	145415657	145415657	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145415657G>A	ENST00000336751.5	+	3	714	c.476G>A	c.(475-477)gGt>gAt	p.G159D	HFE2_ENST00000357836.5_Missense_Mutation_p.G46D|HFE2_ENST00000497365.1_Intron|HFE2_ENST00000475797.1_Intron	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	159					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGGCTGCATGGTCGTCCCCCG	0.687000													14	46					0	0	1	0	0
IL12B	3593	broad.mit.edu	37	5	158745790	158745790	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:158745790G>A	ENST00000231228.2	-	6	1264	c.809C>T	c.(808-810)tCc>tTc	p.S270F		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	270	Fibronectin type-III.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAATGTCAGGGAGAAGTAGGA	0.507000													26	62					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350440	30350440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30350440C>T	ENST00000359358.4	-	2	553	c.115G>A	c.(115-117)Gcc>Acc	p.A39T	KLHL14_ENST00000358095.4_Missense_Mutation_p.A39T|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	39	BTB.					cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						TGGCCCTGGGCCGTCAGGGTC	0.652000													8	60					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411082	126411082	+	Missense_Mutation	SNP	A	A	T	rs139260545	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126411082A>T	ENST00000394329.3	+	17	13118	c.13105A>T	c.(13105-13107)Atg>Ttg	p.M4369L	FAT4_ENST00000335110.5_Missense_Mutation_p.M2610L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4369	Laminin G-like 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CATTGCTTCTATGTGGTATGG	0.438000													65	172					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182026719	182026719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:182026719C>T	ENST00000339948.3	-	2	634	c.427G>A	c.(427-429)Gac>Aac	p.D143N		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						GGTAGTCGGTCCCCAAGAGGT	0.572000													25	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179644778	179644778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179644778C>T	ENST00000589042.1	-	22	3902	c.3678G>A	c.(3676-3678)agG>agA	p.R1226R	TTN_ENST00000342992.6_Silent_p.R1226R|TTN_ENST00000360870.5_Silent_p.R1226R|TTN_ENST00000460472.2_Silent_p.R1180R|TTN_ENST00000342175.6_Silent_p.R1180R|TTN_ENST00000359218.5_Silent_p.R1180R|TTN_ENST00000591111.1_Silent_p.R1226R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1226							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATTTTCTTCCTAATTAAGG	0.333000													36	64					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254404	30254404	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:30254404C>T	ENST00000361644.2	+	5	1100	c.363C>T	c.(361-363)ttC>ttT	p.F121F	MAGEB3_ENST00000378986.1_Silent_p.F121F	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	121	MAGE.									NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						TGGTGCAGTTCCTGATGGAAA	0.393000													20	19					0	0	1	0	0
KCNE1	3753	broad.mit.edu	37	21	35821901	35821901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:35821901G>A	ENST00000337385.3	-	3	407	c.32C>T	c.(31-33)cCc>cTc	p.P11L	KCNE1_ENST00000432085.1_Missense_Mutation_p.P11L|KCNE1_ENST00000399289.3_Missense_Mutation_p.P11L|KCNE1_ENST00000399284.1_Missense_Mutation_p.P11L|KCNE1_ENST00000416357.2_Missense_Mutation_p.P11L|KCNE1_ENST00000399286.2_Missense_Mutation_p.P11L	NM_001270402.1|NM_001270403.1	NP_001257331.1|NP_001257332.1	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related family, member 1	11					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound	lysosome	delayed rectifier potassium channel activity|potassium channel regulator activity			large_intestine(4)|lung(1)|ovary(2)	7					Indapamide(DB00808)	GGTCAGAAAGGGCGTCACCGC	0.587000													13	39					0	0	1	0	0
APOC4-APOC2	100533990	broad.mit.edu	37	19	45448094	45448094	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45448094G>A	ENST00000419266.2	+	2	205	c.165G>A	c.(163-165)aaG>aaA	p.K55K	APOC4-APOC2_ENST00000589057.1_Silent_p.K55K|APOC4_ENST00000592954.1_Silent_p.K55K|APOC4_ENST00000591600.1_Silent_p.K55K|APOC4-APOC2_ENST00000436871.1_Silent_p.K55K																							GCAGGATGAAGGAGCTGCTGG	0.622000													10	6					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30531273	30531273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30531273C>T	ENST00000356798.6	+	30	3504	c.3324C>T	c.(3322-3324)ttC>ttT	p.F1108F	ITGAL_ENST00000358164.5_Silent_p.F1024F|ITGAL_ENST00000433423.2_Silent_p.F342F	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1108					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TGCTCATTTTCATAGTGCTGT	0.587000													14	112					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20328687	20328687	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20328687G>A	ENST00000302555.5	-	8	1413	c.1264C>T	c.(1264-1266)Caa>Taa	p.Q422*	GP2_ENST00000381360.5_Nonsense_Mutation_p.Q278*|GP2_ENST00000381362.4_Nonsense_Mutation_p.Q425*|GP2_ENST00000341642.5_Nonsense_Mutation_p.Q275*			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	425	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GAATCACGTTGATTTGAGCAG	0.478000													14	68					0	0	1	0	0
CD28	940	broad.mit.edu	37	2	204591684	204591684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:204591684G>A	ENST00000374481.3	+	3	351	c.129G>A	c.(127-129)aaG>aaA	p.K43K	CD28_ENST00000374478.4_Intron|CD28_ENST00000324106.7_Silent_p.K127K|CD28_ENST00000458610.2_Silent_p.K141K			P10747	CD28_HUMAN	CD28 molecule	127	Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						ACAATGAGAAGAGCAATGGAA	0.373000													15	72					0	0	1	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679361	37679361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:37679361G>A	ENST00000379800.3	-	1	442	c.33C>T	c.(31-33)ctC>ctT	p.L11L		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	11					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		CTCCCACAACGAGTTCGGCTT	0.592000													41	92					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35949969	35949969	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35949969G>A	ENST00000490799.1	-	8	1307	c.954C>T	c.(952-954)ttC>ttT	p.F318F	SLC26A8_ENST00000355574.2_Silent_p.F318F|SLC26A8_ENST00000394602.2_Silent_p.F213F	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	318					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						CAATCACAGTGAAGCCAATAA	0.418000													37	86					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103400011	103400011	+	Silent	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103400011A>T	ENST00000358392.2	-	46	3947	c.3630T>A	c.(3628-3630)ggT>ggA	p.G1210G	COL11A1_ENST00000370096.3_Silent_p.G1198G|COL11A1_ENST00000512756.1_Silent_p.G1082G|COL11A1_ENST00000353414.4_Silent_p.G1159G	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1198	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTACCTGAAGACCTATTGGAC	0.453000													15	66					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833838	168833838	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168833838C>T	ENST00000464456.1	-	7	2458	c.1258G>A	c.(1258-1260)Gat>Aat	p.D420N	MECOM_ENST00000433243.2_Missense_Mutation_p.D421N|MECOM_ENST00000460814.1_Missense_Mutation_p.D420N|MECOM_ENST00000392736.3_Missense_Mutation_p.D420N|MECOM_ENST00000472280.1_Missense_Mutation_p.D421N|MECOM_ENST00000264674.3_Missense_Mutation_p.D485N|MECOM_ENST00000468789.1_Missense_Mutation_p.D420N|MECOM_ENST00000494292.1_Missense_Mutation_p.D608N	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TTCTCTTTATCACTTTCAATG	0.383000													17	76					0	0	1	0	0
TDP1	55775	broad.mit.edu	37	14	90450874	90450874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90450874C>T	ENST00000335725.4	+	9	1149	c.899C>T	c.(898-900)cCc>cTc	p.P300L	TDP1_ENST00000555880.1_Missense_Mutation_p.P300L|TDP1_ENST00000357382.3_Missense_Mutation_p.P61L|TDP1_ENST00000393454.2_Missense_Mutation_p.P300L|TDP1_ENST00000393452.3_Missense_Mutation_p.P300L	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	300					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGTTGAGCCCCTTATACCCA	0.393000								Repair of DNA-protein crosslinks					50	211					0	0	1	0	0
CYP51A1	1595	broad.mit.edu	37	7	91753076	91753076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:91753076G>A	ENST00000003100.8	-	6	1027	c.862C>T	c.(862-864)Ctc>Ttc	p.L288F	LRRD1_ENST00000422722.1_5'UTR|CYP51A1_ENST00000450723.1_Missense_Mutation_p.L183F	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	282					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	AAAGTTTGGAGAATGTCATCA	0.343000													9	73					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43585109	43585109	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43585109G>A	ENST00000452443.2	-	3	241	c.237C>T	c.(235-237)ttC>ttT	p.F79F		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	79					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CCCGGGTGAGGAAGAATGTGG	0.527000													59	190					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237617862	237617862	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237617862C>T	ENST00000366574.2	+	15	1781	c.1464C>T	c.(1462-1464)ctC>ctT	p.L488L	RYR2_ENST00000360064.6_Silent_p.L486L|RYR2_ENST00000542537.1_Silent_p.L472L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	488					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCAAAATCTCTTCCAGGAAG	0.428000													4	16					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170952658	170952658	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:170952658G>A	ENST00000367759.4	+	9	866	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K	MROH9_ENST00000367758.3_Missense_Mutation_p.E238K	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		TCAACAAGACGAAAGTAAAAT	0.358000													7	39					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58453672	58453672	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58453672G>A	ENST00000282308.3	-	3	700	c.504C>T	c.(502-504)ttC>ttT	p.F168F	ZNF256_ENST00000598928.1_3'UTR	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	168					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		CCTTGCAAGTGAAGGGCTTCC	0.478000													10	108					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	170159870	170159870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:170159870G>A	ENST00000328939.4	+	6	1039	c.502G>A	c.(502-504)Gag>Aag	p.E168K	KCNIP1_ENST00000434108.1_Missense_Mutation_p.E193K|KCNIP1_ENST00000411494.1_Missense_Mutation_p.E179K|KCNIP1_ENST00000520740.1_Missense_Mutation_p.E140K|KCNIP1_ENST00000390656.4_Missense_Mutation_p.E168K|KCNIP1_ENST00000377360.4_Missense_Mutation_p.E177K	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	179	EF-hand 3.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTGCTCAAAGAGGACACTCC	0.498000													21	59					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91169122	91169122	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91169122C>T	ENST00000420329.2	+	10	1011	c.864C>T	c.(862-864)gcC>gcT	p.A288A	CRTC3_ENST00000268184.6_Silent_p.A288A|RP11-387D10.2_ENST00000559531.1_RNA	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	288					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CCCTGCCAGCCTCCCTGGACA	0.542000			T	MAML2	salivary gland mucoepidermoid								72	532					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74208526	74208526	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74208526C>T	ENST00000269391.6	-	2	258	c.126G>A	c.(124-126)gaG>gaA	p.E42E	RNF157_ENST00000592271.1_Silent_p.E42E|RNF157_ENST00000319945.6_Silent_p.E42E	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	42							zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			AGTCAAACTTCTCTCCTCCCA	0.403000													8	83					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999077	46999077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46999077G>A	ENST00000374314.4	+	1	1152	c.197G>A	c.(196-198)gGg>gAg	p.G66E	GPRIN2_ENST00000374317.1_Missense_Mutation_p.G66E			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	66										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						GAGGAAGAGGGGAACCCGCCT	0.692000													11	80					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66879961	66879961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66879961C>T	ENST00000269080.2	-	27	3695	c.3558G>A	c.(3556-3558)aaG>aaA	p.K1186K	ABCA8_ENST00000586539.1_Silent_p.K1226K|ABCA8_ENST00000430352.2_Silent_p.K1226K	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1186						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TCATTGATTTCTTTCCAAACT	0.284000													13	36					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383124	108383124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108383124C>T	ENST00000265843.4	-	6	3220	c.3110G>A	c.(3109-3111)gGa>gAa	p.G1037E	EXPH5_ENST00000428840.1_Missense_Mutation_p.G961E|EXPH5_ENST00000443411.1_Missense_Mutation_p.G849E|EXPH5_ENST00000525344.1_Missense_Mutation_p.G1030E	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1037					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TATTTTACTTCCTGACTGCCT	0.373000													29	68					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50055509	50055509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50055509G>A	ENST00000281631.5	+	4	375	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	PARP8_ENST00000511363.2_Intron|PARP8_ENST00000505697.2_Missense_Mutation_p.E73K|PARP8_ENST00000503750.2_Missense_Mutation_p.E73K|PARP8_ENST00000505554.1_Missense_Mutation_p.E52K|PARP8_ENST00000514067.2_Missense_Mutation_p.E73K|PARP8_ENST00000514342.2_5'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	73						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				AGAGAATGATGAAGATGTGCT	0.244000													16	85					0	0	1	0	0
CD79A	973	broad.mit.edu	37	19	42383213	42383213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42383213C>T	ENST00000221972.3	+	2	418	c.233C>T	c.(232-234)cCt>cTt	p.P78L	CD79A_ENST00000444740.2_Missense_Mutation_p.P78L	NM_001783.3|NM_021601.3	NP_001774.1|NP_067612.1	P11912	CD79A_HUMAN	CD79a molecule, immunoglobulin-associated alpha	78	Ig-like C2-type.				B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11						ACGTGGCCCCCTGAGTTCTTG	0.617000			"""O, S"""		DLBCL								29	77					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285448	48285448	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48285448C>T	ENST00000320048.1	+	1	36	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						AAATAATTTTCGTGGGATTTT	0.428000													26	30					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83711968	83711968	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:83711968C>T	ENST00000566620.1	+	10	1730	c.1440C>T	c.(1438-1440)gaC>gaT	p.D480D	CDH13_ENST00000428848.3_Silent_p.D441D|CDH13_ENST00000268613.10_Silent_p.D527D	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	480	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TCTACCCAGACCCCATGATGG	0.612000													9	55					0	0	1	0	0
MAN1C1	57134	broad.mit.edu	37	1	26104708	26104708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26104708G>A	ENST00000374332.4	+	9	1700	c.1370G>A	c.(1369-1371)gGc>gAc	p.G457D	MAN1C1_ENST00000374329.1_Missense_Mutation_p.G228D|MAN1C1_ENST00000263979.3_Missense_Mutation_p.G277D	NM_020379.2	NP_065112.1	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	457					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(7)|pancreas(1)|prostate(1)|skin(2)	25		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		TTCTCCGGGGGCATGATCGCC	0.612000													21	44					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39987429	39987429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:39987429C>T	ENST00000373257.3	+	20	2570	c.2479C>T	c.(2479-2481)Ctg>Ttg	p.L827L	LPIN3_ENST00000491528.1_3'UTR	NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	827					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				CAGCACAGACCTGGCCAACCC	0.617000													12	135					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150266998	150266998	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150266998C>T	ENST00000255945.2	+	2	184	c.9C>T	c.(7-9)gcC>gcT	p.A3A	GIMAP4_ENST00000461940.1_Silent_p.A3A|GIMAP4_ENST00000494750.1_Intron	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	3							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAATGGCAGCCCAATACGGCA	0.512000													17	58					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152847233	152847233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152847233G>A	ENST00000367255.5	-	5	808	c.207C>T	c.(205-207)gtC>gtT	p.V69V	SYNE1_ENST00000466159.2_Silent_p.V69V|SYNE1_ENST00000341594.5_Silent_p.V69V|SYNE1_ENST00000367248.3_Silent_p.V69V|SYNE1_ENST00000423061.1_Silent_p.V69V|SYNE1_ENST00000448038.1_Silent_p.V69V|SYNE1_ENST00000265368.4_Silent_p.V69V|SYNE1_ENST00000413186.2_Silent_p.V69V|SYNE1_ENST00000367253.4_Silent_p.V69V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	69	Actin-binding.|CH 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCCCAGACAGGACCTCCAGAA	0.413000										HNSCC(10;0.0054)			6	78					0	0	1	0	0
PLAU	5328	broad.mit.edu	37	10	75673453	75673453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75673453C>T	ENST00000446342.1	+	6	1048	c.566C>T	c.(565-567)aCc>aTc	p.T189I	C10orf55_ENST00000412307.2_Intron|C10orf55_ENST00000409178.1_Intron|PLAU_ENST00000372764.3_Missense_Mutation_p.T206I|PLAU_ENST00000372762.4_Missense_Mutation_p.T170I|PLAU_ENST00000494287.1_3'UTR	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	206	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	GGCTCTGTCACCTACGTGTGT	0.592000													32	98					0	0	1	0	0
TNRC6C	57690	broad.mit.edu	37	17	76098601	76098601	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76098601C>T	ENST00000335749.4	+	19	5225	c.4656C>T	c.(4654-4656)ctC>ctT	p.L1552L	TNRC6C_ENST00000541771.1_Silent_p.L1516L|TNRC6C_ENST00000588061.1_Silent_p.L1516L|TNRC6C_ENST00000588847.1_Silent_p.L1552L|TNRC6C_ENST00000544502.1_Silent_p.L1552L|TNRC6C_ENST00000301624.4_Silent_p.L1516L	NM_001142640.1	NP_001136112.1	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C	1516	Sufficient for translational repression when tethered to a target mRNA.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GCAGCTGGCTCGTTCTTCGAA	0.592000													6	17					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110477426	110477426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110477426C>T	ENST00000378402.5	+	49	8469	c.8365C>T	c.(8365-8367)Cgc>Tgc	p.R2789C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2789					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGCTGGCTTTCGCTGGGAACA	0.393000										HNSCC(38;0.096)			27	49					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56917978	56917978	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56917978C>T	ENST00000438926.2	+	14	1716	c.1687C>T	c.(1687-1689)Caa>Taa	p.Q563*	SLC12A3_ENST00000262502.5_Nonsense_Mutation_p.Q562*|SLC12A3_ENST00000563236.1_Nonsense_Mutation_p.Q563*|SLC12A3_ENST00000566786.1_Nonsense_Mutation_p.Q562*	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	563					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	ACCTTCATTCCAATACTACAA	0.612000													12	49					0	0	1	0	0
THPO	7066	broad.mit.edu	37	3	184090609	184090609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184090609C>T	ENST00000204615.7	-	6	968	c.754G>A	c.(754-756)Gaa>Aaa	p.E252K	EIF2B5_ENST00000444495.1_Intron|THPO_ENST00000421442.2_Missense_Mutation_p.R213Q|THPO_ENST00000445696.2_Missense_Mutation_p.E248K	NM_000460.2|NM_001177597.1|NM_001177598.1	NP_000451.1|NP_001171068.1|NP_001171069.1	P40225	TPO_HUMAN	thrombopoietin	252					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity	p.E252K(1)		NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCAAGAGTTCGTGTATCCTG	0.557000													26	106					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160850442	160850442	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160850442G>A	ENST00000326245.3	-	6	736	c.621C>T	c.(619-621)atC>atT	p.I207I	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	207	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGACCACAGGGATCACCGGGC	0.443000													72	164					0	0	1	0	0
WDR19	57728	broad.mit.edu	37	4	39245969	39245969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39245969C>T	ENST00000399820.3	+	22	2677	c.2523C>T	c.(2521-2523)gtC>gtT	p.V841V	WDR19_ENST00000288634.7_Silent_p.V681V	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	841					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						CCAGCAGGGTCCTTAAAAGAG	0.428000													30	71					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11022970	11022970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:11022970C>T	ENST00000304623.8	-	17	3099	c.2910G>A	c.(2908-2910)gtG>gtA	p.V970V	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Silent_p.V537V|CTNND2_ENST00000511377.1_Silent_p.V879V|CTNND2_ENST00000503622.1_Silent_p.V633V|CTNND2_ENST00000359640.2_Silent_p.V912V	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	970					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TCTTGGTAATCACTTCGTGCA	0.517000													31	60					0	0	1	0	0
PRDM5	11107	broad.mit.edu	37	4	121774680	121774680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:121774680C>T	ENST00000264808.3	-	3	433	c.193G>A	c.(193-195)Gga>Aga	p.G65R	PRDM5_ENST00000428209.2_Missense_Mutation_p.G65R|PRDM5_ENST00000515109.1_Missense_Mutation_p.G65R|PRDM5_ENST00000394435.2_Missense_Mutation_p.G65R	NM_018699.2	NP_061169.2	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	65	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding	p.G65*(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(17)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AAAACTTCTCCCTTACTCCCA	0.448000													28	337					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41582040	41582040	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41582040G>A	ENST00000396942.1	-	7	728	c.645C>T	c.(643-645)caC>caT	p.H215H	ANK1_ENST00000352337.4_Silent_p.H215H|ANK1_ENST00000396945.1_Silent_p.H215H|ANK1_ENST00000289734.7_Silent_p.H215H|ANK1_ENST00000379758.2_Silent_p.H215H|ANK1_ENST00000265709.8_Silent_p.H248H|ANK1_ENST00000347528.4_Silent_p.H215H			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	215	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGTTCTCGTAGTGAGCCGCAA	0.562000													3	5					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51448530	51448530	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51448530G>A	ENST00000298355.3	-	8	3016	c.1895C>T	c.(1894-1896)tCg>tTg	p.S632L	TRIM9_ENST00000338969.5_Missense_Mutation_p.S713L	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	632	B30.2/SPRY.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					GTTGGTGTGCGAGTTGTTGTG	0.498000													45	119					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12969475	12969475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12969475G>A	ENST00000251472.4	+	12	1327	c.1288G>A	c.(1288-1290)Gag>Aag	p.E430K	MAST1_ENST00000591495.1_Missense_Mutation_p.E426K	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	430	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CACCTTCGCCGAGAACCCGTT	0.572000													22	40					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55219018	55219018	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55219018G>A	ENST00000275493.2	+	5	768	c.591G>A	c.(589-591)ggG>ggA	p.G197G	EGFR_ENST00000344576.2_Silent_p.G197G|EGFR_ENST00000420316.2_Silent_p.G197G|EGFR_ENST00000454757.2_Silent_p.G144G|EGFR_ENST00000442591.1_Silent_p.G197G|EGFR_ENST00000342916.3_Silent_p.G197G|EGFR_ENST00000455089.1_Silent_p.G152G	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	197					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTCCCAATGGGAGCTGCTGGG	0.502000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			23	119					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101773360	101773360	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101773360G>A	ENST00000334289.3	-	6	1127	c.532C>T	c.(532-534)Cca>Tca	p.P178S		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	178	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		ACCTCAAATGGGTAGCTAGAT	0.333000													30	68					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120903846	120903846	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120903846C>T	ENST00000263713.5	+	20	1988	c.1774C>T	c.(1774-1776)Cag>Tag	p.Q592*	EPB41L5_ENST00000443902.2_Nonsense_Mutation_p.Q592*|EPB41L5_ENST00000452780.1_Nonsense_Mutation_p.Q592*	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	592						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TGCCAATGTTCAGGATGCTGC	0.308000													12	31					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119216557	119216557	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119216557G>A	ENST00000555262.1	-	4	512	c.353C>T	c.(352-354)aCc>aTc	p.T118I	C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR|MFRP_ENST00000449574.2_Missense_Mutation_p.T118I|MFRP_ENST00000360167.4_Missense_Mutation_p.T118I|MFRP_ENST00000530681.1_Missense_Mutation_p.T118I	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		ggtggtgatggtgggggtggt	0.657000													27	61					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760833	62760833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62760833G>A	ENST00000311438.8	-	9	1591	c.1592C>T	c.(1591-1593)gCt>gTt	p.A531V	SLC22A8_ENST00000535878.1_Intron|SLC22A8_ENST00000336232.2_Intron|SLC22A8_ENST00000545207.1_Intron|SLC22A8_ENST00000430500.2_Intron			Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	61					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						CTAAGGAAAAGCCCTGGGCCC	0.597000													12	33					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159654630	159654630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159654630C>T	ENST00000297267.9	+	11	3286	c.3086C>T	c.(3085-3087)tCc>tTc	p.S1029F	FNDC1_ENST00000340366.6_Missense_Mutation_p.S966F	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1029						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CGGTCACCTTCCCAGCCCAGG	0.736000													4	5					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34867273	34867273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34867273G>A	ENST00000431794.3	-	12	1438	c.916C>T	c.(916-918)Ctt>Ttt	p.L306F	MYO19_ENST00000268852.9_Missense_Mutation_p.L306F	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	306	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ATATTGCCAAGGTGCAGCAGT	0.607000													2	0					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24121450	24121450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24121450C>T	ENST00000215743.3	+	2	237	c.185C>T	c.(184-186)gCc>gTc	p.A62V	MMP11_ENST00000477567.1_3'UTR	NM_005940.3	NP_005931.2	P24347	MMP11_HUMAN	matrix metallopeptidase 11 (stromelysin 3)	62					collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	27		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				CCGGCACCTGCCCCTGCCACG	0.711000													11	15					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124390562	124390562	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124390562G>A	ENST00000368909.3	+	46	5830	c.5724G>A	c.(5722-5724)ggG>ggA	p.G1908G	DMBT1_ENST00000330163.4_Silent_p.G1280G|DMBT1_ENST00000368955.3_Silent_p.G1898G|DMBT1_ENST00000359586.6_Silent_p.G628G|DMBT1_ENST00000368956.2_Silent_p.G1280G|DMBT1_ENST00000344338.3_Silent_p.G1898G|DMBT1_ENST00000338354.3_Silent_p.G1908G	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1908	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCACCTGGGGGACAGTTTGTG	0.483000													17	39					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7526061	7526061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7526061G>A	ENST00000313599.3	-	14	3642	c.3585C>T	c.(3583-3585)gcC>gcT	p.A1195A	CD163L1_ENST00000416109.2_Silent_p.A1205A|CD163L1_ENST00000396630.1_Silent_p.A1195A			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1195	SRCR 11.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TAGATAAAGGGGCGAGGCTGA	0.567000													16	133					0	0	1	0	0
USP32P3	347716	broad.mit.edu	37	17	20320092	20320092	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:20320092C>T	ENST00000583574.2	+	0	333																											GGGGCTGACCCAGAGGAAGTC	0.567000													8	17					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107230086	107230086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:107230086G>A	ENST00000273980.4	-	3	479	c.32C>T	c.(31-33)gCc>gTc	p.A11V	TBCK_ENST00000394706.3_Missense_Mutation_p.A11V|TBCK_ENST00000361687.4_Missense_Mutation_p.A11V|TBCK_ENST00000432496.2_Missense_Mutation_p.A11V|TBCK_ENST00000394708.2_Missense_Mutation_p.A11V			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	11	Protein kinase.					intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						GAAGGTAAAGGCTCCCATTTC	0.428000													20	38					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926341	1926341	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1926341C>T	ENST00000399161.2	-	10	1947	c.1200G>A	c.(1198-1200)gcG>gcA	p.A400A	MYT1L_ENST00000428368.2_Silent_p.A400A	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	400					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CATCCTCCTTCGCACAGCTGG	0.597000													17	25					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125671718	125671718	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125671718G>A	ENST00000431078.1	+	24	4138	c.3774G>A	c.(3772-3774)atG>atA	p.M1258I		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1258					cell adhesion|signal transduction	integral to membrane	receptor binding	p.M1258I(1)		NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCGGCATCATGACCCGGTTCC	0.453000													60	123					0	0	1	0	0
LRRC16A	55604	broad.mit.edu	37	6	25610314	25610314	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:25610314C>T	ENST00000329474.6	+	36	4252	c.3884C>T	c.(3883-3885)gCc>gTc	p.A1295V		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1295					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						CCGAAAGTTGCCCTTCTTCCA	0.478000													55	151					0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149241047	149241047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:149241047C>T	ENST00000404807.1	+	5	3016	c.2887C>T	c.(2887-2889)Ccg>Tcg	p.P963S	MBD5_ENST00000407073.1_Intron			Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	968						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TTTTCTCAACCCGAATGTAAA	0.463000													23	39					0	0	1	0	0
NAALADL2	254827	broad.mit.edu	37	3	174951855	174951855	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:174951855C>T	ENST00000454872.1	+	3	808	c.680C>T	c.(679-681)tCt>tTt	p.S227F	NAALADL2_ENST00000473253.1_3'UTR	NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	227					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CCAGGCCCTTCTCCCAGCACT	0.473000													40	69					0	0	1	0	0
PAX2	5076	broad.mit.edu	37	10	102584444	102584444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102584444C>T	ENST00000370296.2	+	9	1578	c.1028C>T	c.(1027-1029)cCt>cTt	p.P343L	PAX2_ENST00000428433.1_Missense_Mutation_p.P343L|PAX2_ENST00000355243.3_Missense_Mutation_p.P320L|PAX2_ENST00000361791.3_Missense_Mutation_p.P320L|PAX2_ENST00000556085.1_Missense_Mutation_p.P319L			Q02962	PAX2_HUMAN	paired box 2	343					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		GGTTACCCCCCTCACGTGCCC	0.612000													60	135					0	0	1	0	0
TUBBP1	92755	broad.mit.edu	37	8	30210015	30210015	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30210015G>A	ENST00000518096.1	+	0	627																											ATCGCATCATGAATACCTTCA	0.532000													18	39					0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52918892	52918892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52918892C>T	ENST00000360465.3	+	7	1213	c.787C>T	c.(787-789)Cat>Tat	p.H263Y	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TCAAAGAATTCATACTGGAGA	0.398000													33	101					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476262	120476262	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:120476262C>T	ENST00000355622.6	+	3	1957	c.1856C>T	c.(1855-1857)cCt>cTt	p.P619L	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.P579L	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	619	LRRCT.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CAGGGCATGCCTGTGCTGAGT	0.468000													8	30					0	0	1	0	0
VAC14	55697	broad.mit.edu	37	16	70778438	70778438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70778438G>A	ENST00000261776.5	-	13	1676	c.1416C>T	c.(1414-1416)tcC>tcT	p.S472S		NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	472					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				GGCCTGCGGGGGAGGAAGCGA	0.672000													10	54					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724783	138724783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:138724783C>T	ENST00000383163.2	-	1	327	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	110										endometrium(3)|kidney(1)|lung(7)	11						CCTGAGCGTTCGTCGACAGAG	0.617000													12	21					0	0	1	0	0
IFNL2	282616	broad.mit.edu	37	19	39759326	39759326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39759326G>A	ENST00000331982.5	+	2	75	c.20G>A	c.(19-21)gGg>gAg	p.G7E		NM_172138.1	NP_742150.1			interferon, lambda 2																		GACATGACTGGGGACTGCACG	0.647000													5	58					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115963932	115963932	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115963932G>A	ENST00000251864.2	+	9	1235	c.1082G>A	c.(1081-1083)aGa>aAa	p.R361K	TDRD1_ENST00000369281.2_Missense_Mutation_p.R361K|TDRD1_ENST00000369282.1_Missense_Mutation_p.R361K|TDRD1_ENST00000369280.1_Missense_Mutation_p.R361K|TDRD1_ENST00000422662.1_Intron	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	361	Tudor 1.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CCATTAAACAGAATTTACCAC	0.353000													18	62					0	0	1	0	0
HOXA5	3202	broad.mit.edu	37	7	27183048	27183048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27183048C>T	ENST00000222726.3	-	1	239	c.179G>A	c.(178-180)gGc>gAc	p.G60D	HOXA-AS3_ENST00000518848.1_RNA|HOXA-AS3_ENST00000521197.1_RNA|HOXA3_ENST00000467897.2_Intron	NM_019102.3	NP_061975.2	P20719	HXA5_HUMAN	homeobox A5	60					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(12)|skin(1)	16						GTGGCCGGAGCCCGAGCGGCC	0.697000													15	41					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36241637	36241637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36241637G>A	ENST00000540320.1	+	56	9062	c.8528G>A	c.(8527-8529)cGa>cAa	p.R2843Q	NBEA_ENST00000379939.2_Missense_Mutation_p.R2840Q|NBEA_ENST00000379922.3_Missense_Mutation_p.R421Q|NBEA_ENST00000310336.4_Missense_Mutation_p.R2843Q|NBEA_ENST00000537702.1_Missense_Mutation_p.R636Q|NBEA_ENST00000400445.3_Missense_Mutation_p.R2843Q			Q8NFP9	NBEA_HUMAN	neurobeachin	2843						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TACTATGAACGAGGGCGATTC	0.433000													58	159					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873264	36873264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36873264G>A	ENST00000301807.6	-	21	7925	c.6028C>T	c.(6028-6030)Cct>Tct	p.P2010S	TRANK1_ENST00000429976.2_Missense_Mutation_p.P2560S|TRANK1_ENST00000428977.2_Missense_Mutation_p.P2010S	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2560					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ACCTGGCCAGGGCAGTCCATG	0.572000													26	71					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45725690	45725690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:45725690C>T	ENST00000297323.7	+	13	2225	c.2203C>T	c.(2203-2205)Ctg>Ttg	p.L735L		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	735					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	GCTCTGCTGCCTGGTGGGCAC	0.617000													27	47					0	0	1	0	0
ACADSB	36	broad.mit.edu	37	10	124802595	124802595	+	Missense_Mutation	SNP	C	C	T	rs138063747		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124802595C>T	ENST00000358776.4	+	6	729	c.715C>T	c.(715-717)Cgt>Tgt	p.R239C	ACADSB_ENST00000496730.2_3'UTR|ACADSB_ENST00000368869.4_Missense_Mutation_p.R137C	NM_001609.3	NP_001600.1	P45954	ACDSB_HUMAN	acyl-CoA dehydrogenase, short/branched chain	239					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	CTTAGTAGATCGTGATACTCC	0.398000													45	110					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50139825	50139825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50139825G>A	ENST00000371564.3	-	2	1174	c.955C>T	c.(955-957)Ccc>Tcc	p.P319S	NFATC2_ENST00000414705.1_Missense_Mutation_p.P299S|NFATC2_ENST00000396009.3_Missense_Mutation_p.P319S	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	319					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					ATCTTGGGGGGGATCCCACAA	0.687000													16	30					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061180	9061180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9061180G>A	ENST00000397910.4	-	3	26469	c.26266C>T	c.(26266-26268)Cct>Tct	p.P8756S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8758	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATTGAGCAGGACCTGGGGTG	0.498000													20	79					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51412344	51412344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:51412344C>T	ENST00000319760.6	-	1	104	c.52G>A	c.(52-54)Gat>Aat	p.D18N		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				ACACCAGGATCCTGAGAAAAG	0.428000													16	38					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67402484	67402484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67402484G>A	ENST00000335385.3	-	2	345	c.258C>T	c.(256-258)atC>atT	p.I86I		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	86					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						CCTTGGTGACGATCATCTCAG	0.647000													14	30					0	0	1	0	0
PHACTR2	9749	broad.mit.edu	37	6	144128271	144128271	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:144128271G>A	ENST00000427704.2	+	12	2019		c.e12+1		RP3-468K18.5_ENST00000545614.1_Splice_Site|PHACTR2_ENST00000367582.3_Splice_Site|PHACTR2_ENST00000367584.4_Splice_Site|PHACTR2_ENST00000305766.6_Splice_Site|PHACTR2_ENST00000440869.2_Splice_Site	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2								actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		AGTTTACAAGGTAGGTGACAA	0.313000													28	27					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6081974	6081974	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6081974C>T	ENST00000409021.3	-	7	1616	c.1167G>A	c.(1165-1167)acG>acA	p.T389T	JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000410077.2_Silent_p.T224T|JAKMIP1_ENST00000409831.1_Silent_p.T389T|JAKMIP1_ENST00000282924.5_Silent_p.T389T|JAKMIP1_ENST00000409371.3_Silent_p.T224T	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	389	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCTCATCCCTCGTCAGGCTGA	0.582000													12	40					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20522568	20522568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20522568G>A	ENST00000359062.3	+	1	390	c.350G>A	c.(349-351)gGa>gAa	p.G117E	RP11-284H19.1_ENST00000535755.1_RNA	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	117					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGGCCTCGGGGAGGTGCTCCC	0.706000													4	8					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43441253	43441253	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43441253C>T	ENST00000446844.3	-	0	65				PSG7_ENST00000406070.2_RNA|PSG7_ENST00000471557.1_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GCGTGTTCTCCTCTGTGGAGA	0.597000													37	80					0	0	1	0	0
MRM1	79922	broad.mit.edu	37	17	34964684	34964684	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34964684C>T	ENST00000250156.7	+	5	1134	c.895C>T	c.(895-897)Ctt>Ttt	p.L299F	MRM1_ENST00000585770.1_Missense_Mutation_p.L104F	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	299					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TGCAGGAATTCTTCTTCACTC	0.542000													82	108					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360240	27360240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27360240C>T	ENST00000335524.3	-	3	1483	c.958G>A	c.(958-960)Gaa>Aaa	p.E320K		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	320										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCCTGCTTCCTTCGGCCTT	0.667000													25	60					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121381702	121381702	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121381702A>C	ENST00000297848.3	+	47	5559	c.5289A>C	c.(5287-5289)tcA>tcC	p.S1763S	COL14A1_ENST00000247781.3_Silent_p.S1668S|COL14A1_ENST00000309791.4_Silent_p.S1763S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1763	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACCCCTCATCATGTTCTGCCT	0.532000													23	80					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51092883	51092883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:51092883G>A	ENST00000395542.2	-	14	4121	c.3937C>T	c.(3937-3939)Ctc>Ttc	p.L1313F	COBL_ENST00000265136.7_Missense_Mutation_p.L1231F			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1231										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GTGTTGCTGAGGGTGCCCGTG	0.647000													18	74					0	0	1	0	0
CCDC92	80212	broad.mit.edu	37	12	124421994	124421994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124421994G>A	ENST00000545135.1	-	3	3852	c.556C>T	c.(556-558)Cgc>Tgc	p.R186C	CCDC92_ENST00000545891.1_Missense_Mutation_p.R186C|CCDC92_ENST00000238156.3_Missense_Mutation_p.R203C|CCDC92_ENST00000544798.1_Intron			Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	203										large_intestine(5)|lung(2)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		ATGCGGCGGCGAGGCGTTTCG	0.617000													25	59					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72596824	72596824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:72596824G>A	ENST00000264839.7	+	1	98	c.98G>A	c.(97-99)aGg>aAg	p.R33K	RIMS1_ENST00000348717.5_Missense_Mutation_p.R33K|RIMS1_ENST00000517960.1_Missense_Mutation_p.R33K|RIMS1_ENST00000491071.2_Missense_Mutation_p.R33K|RIMS1_ENST00000522291.1_Missense_Mutation_p.R33K|RIMS1_ENST00000521978.1_Missense_Mutation_p.R33K|RIMS1_ENST00000520567.1_Missense_Mutation_p.R33K|RIMS1_ENST00000518273.1_Missense_Mutation_p.R33K			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	33	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GAAGAGGAGAGGAACATTATC	0.622000													15	15					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51100335	51100335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51100335C>T	ENST00000301180.5	+	21	2455	c.2421C>T	c.(2419-2421)ttC>ttT	p.F807F		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	807						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						GTTTGGTGTTCGTGGTTGGGA	0.363000													38	95					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	780476	780476	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:780476C>T	ENST00000297440.6	+	3	821	c.801C>T	c.(799-801)tcC>tcT	p.S267S	HEATR2_ENST00000313147.5_Silent_p.S267S|HEATR2_ENST00000438961.1_3'UTR	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	267							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CGGTGGCCTCCGTGGTGGGCG	0.642000													46	194					0	0	1	0	0
SIX2	10736	broad.mit.edu	37	2	45233467	45233467	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:45233467G>A	ENST00000303077.6	-	2	1037	c.718C>T	c.(718-720)Ctg>Ttg	p.L240L		NM_016932.4	NP_058628.3	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	240						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(6)|large_intestine(3)|lung(8)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	22		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGGGACGGCAGCCCAGGGGGC	0.701000													27	79					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3672097	3672097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3672097C>T	ENST00000294600.2	+	3	603	c.519C>T	c.(517-519)ttC>ttT	p.F173F		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	173										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AGGACCTGTTCTTGGCCAGGC	0.617000													102	226					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328431	57328431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57328431G>A	ENST00000326441.9	-	10	1742	c.1379C>T	c.(1378-1380)tCg>tTg	p.S460L	PEG3_ENST00000423103.2_Missense_Mutation_p.S460L|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.S334L|PEG3_ENST00000598410.1_Missense_Mutation_p.S336L|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	460					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GACACTGAACGACCTCCCACA	0.493000													65	134					0	0	1	0	0
LRFN3	79414	broad.mit.edu	37	19	36431004	36431004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36431004C>T	ENST00000588831.1	+	3	1731	c.677C>T	c.(676-678)tCc>tTc	p.S226F	LRFN3_ENST00000246529.3_Missense_Mutation_p.S226F			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	226					cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCACTCTTCTCCCGCCTGCCC	0.701000													50	130					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167796357	167796357	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:167796357T>A	ENST00000366827.2	-	2	216	c.5A>T	c.(4-6)gAg>gTg	p.E2V	TCP10_ENST00000476779.2_Missense_Mutation_p.E2V|TCP10_ENST00000397829.4_Missense_Mutation_p.E2V			Q12799	TCP10_HUMAN	t-complex 10	29						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		AGGTGTCTTCTCCATGGCAGC	0.667000													5	10					0	0	1	0	0
PLD4	122618	broad.mit.edu	37	14	105396385	105396385	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105396385G>A	ENST00000540372.1	+	6	873	c.681G>A	c.(679-681)gtG>gtA	p.V227V	PLD4_ENST00000392593.4_Silent_p.V220V			Q96BZ4	PLD4_HUMAN	phospholipase D family, member 4	220	PLD phosphodiesterase 1.				lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	13		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	TCTGGGTTGTGGATGGACGGC	0.587000													22	69					0	0	1	0	0
MYCN	4613	broad.mit.edu	37	2	16086016	16086016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:16086016C>T	ENST00000281043.3	+	3	1489	c.1192C>T	c.(1192-1194)Cgg>Tgg	p.R398W		NM_005378.4	NP_005369.2	P04198	MYCN_HUMAN	v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog	398	Helix-loop-helix motif.				regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CAACGACCTTCGGTCCAGCTT	0.567000			A		neuroblastoma								48	114					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118230475	118230475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:118230475C>T	ENST00000402510.2	-	8	1247	c.1248G>A	c.(1246-1248)aaG>aaA	p.K416K		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	416										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						GAAGGTTCTTCTTTTGTTTGC	0.463000													13	11					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94514490	94514490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94514490C>T	ENST00000370225.3	-	18	2763	c.2677G>A	c.(2677-2679)Gcc>Acc	p.A893T	ABCA4_ENST00000535735.1_Missense_Mutation_p.A819T	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	893					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TTTTCCAGGGCTCTTTCTTCT	0.532000													17	79					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38103775	38103775	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38103775C>T	ENST00000308059.6	+	4	810	c.789C>T	c.(787-789)ttC>ttT	p.F263F	DLEC1_ENST00000346219.3_Silent_p.F263F|DLEC1_ENST00000452631.2_Silent_p.F263F			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	263					negative regulation of cell proliferation	cytoplasm		p.F263F(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		TTGCTGAGTTCGAAGATGAGT	0.453000													26	67					0	0	1	0	0
FAM134A	79137	broad.mit.edu	37	2	220047103	220047103	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220047103C>T	ENST00000430297.2	+	9	1520	c.1384C>T	c.(1384-1386)Ccc>Tcc	p.P462S		NM_024293.4	NP_077269.3	Q8NC44	F134A_HUMAN	family with sequence similarity 134, member A	462						endoplasmic reticulum|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	19		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGACCCAGCCCCCTCCCCTTC	0.617000													69	145					0	0	1	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157266	65157266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65157266C>T	ENST00000323544.4	+	6	780	c.652C>T	c.(652-654)Cct>Tct	p.P218S	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	218	Pro-rich.									NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						GACCACCAGCCCTGGTGACAG	0.627000													21	176					0	0	1	0	0
GDF9	2661	broad.mit.edu	37	5	132197639	132197639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132197639G>A	ENST00000378673.2	-	3	1873	c.1007C>T	c.(1006-1008)tCc>tTc	p.S336F	GDF9_ENST00000296875.2_Missense_Mutation_p.S336F			O60383	GDF9_HUMAN	growth differentiation factor 9	336					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGATTGAAGGAAGCTGGGCC	0.483000													36	91					0	0	1	0	0
SRP14	6727	broad.mit.edu	37	15	40328545	40328545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40328545C>T	ENST00000267884.6	-	5	471	c.400G>A	c.(400-402)Gca>Aca	p.A134T	SRP14_ENST00000558527.1_5'UTR|SRP14_ENST00000560773.1_Missense_Mutation_p.A54T|SRP14_ENST00000558720.1_Missense_Mutation_p.A54T	NM_003134.4	NP_003125.3	P37108	SRP14_HUMAN	signal recognition particle 14kDa (homologous Alu RNA binding protein)	134	Ala/Thr-rich.				negative regulation of translational elongation|response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|endoplasmic reticulum signal peptide binding|protein binding			endometrium(1)|skin(1)|upper_aerodigestive_tract(1)	3		all_cancers(109;7.56e-18)|all_epithelial(112;4.02e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.84e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0505)		TACTGtgctgctgttgctgct	0.488000													18	67					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754848	49754848	+	Missense_Mutation	SNP	C	C	T	rs149194608		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49754848C>T	ENST00000304801.3	-	1	205	c.53G>A	c.(52-54)cGa>cAa	p.R18Q		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	18					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CATGATGACTCGCTTCCCTCT	0.418000													33	76					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38646287	38646287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38646287G>A	ENST00000413689.1	-	11	1644	c.1451C>T	c.(1450-1452)tCa>tTa	p.S484L	SCN5A_ENST00000423572.2_Missense_Mutation_p.S484L|SCN5A_ENST00000425664.1_Missense_Mutation_p.S484L|SCN5A_ENST00000455624.2_Missense_Mutation_p.S484L|SCN5A_ENST00000450102.2_Missense_Mutation_p.S484L|SCN5A_ENST00000449557.2_Missense_Mutation_p.S484L|SCN5A_ENST00000414099.2_Missense_Mutation_p.S484L|SCN5A_ENST00000451551.2_Missense_Mutation_p.S484L|SCN5A_ENST00000333535.4_Missense_Mutation_p.S484L|SCN5A_ENST00000443581.1_Missense_Mutation_p.S484L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	484					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CTCAGTTCCTGAAGACATCCG	0.542000													8	42					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634652	32634652	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32634652G>A	ENST00000242310.4	-	1	1015	c.926C>T	c.(925-927)tCt>tTt	p.S309F	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	309					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GTTCCACAAAGACTTCTGGCT	0.498000													40	125					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049182	9049182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9049182C>T	ENST00000397910.4	-	5	32652	c.32449G>A	c.(32449-32451)Gaa>Aaa	p.E10817K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10819	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTAGCTGGTTCACCAGGGGAG	0.483000													61	123					0	0	1	0	0
CLRN3	119467	broad.mit.edu	37	10	129681992	129681992	+	Missense_Mutation	SNP	G	G	A	rs141771225		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129681992G>A	ENST00000368671.3	-	2	539	c.377C>T	c.(376-378)cCg>cTg	p.P126L		NM_152311.3	NP_689524.1	Q8NCR9	CLRN3_HUMAN	clarin 3	126						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				CACCCCCGTCGGCCCCAGGAA	0.572000													28	66					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100551777	100551777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100551777C>T	ENST00000319509.7	+	1	528	c.528C>T	c.(526-528)atC>atT	p.I176I						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TGAGCACGATCGTGTCAACAT	0.473000													42	517					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226453307	226453307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:226453307G>A	ENST00000328205.5	-	10	1558	c.1013C>T	c.(1012-1014)cCg>cTg	p.P338L	LIN9_ENST00000481685.1_Missense_Mutation_p.P303L|LIN9_ENST00000366801.1_Missense_Mutation_p.P287L	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	322					cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		ACTTCTCCACGGCGACTGTCC	0.318000													16	50					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135587422	135587422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135587422C>T	ENST00000513104.1	-	6	1776	c.1494G>A	c.(1492-1494)gaG>gaA	p.E498E	TRPC7_ENST00000355180.3_Silent_p.E437E|TRPC7_ENST00000426057.2_Silent_p.E382E	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	498					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACAGCTGTGCCTCCGTGGCCT	0.582000													9	23					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14508475	14508475	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14508475C>T	ENST00000344204.4	+	57	9262	c.9238C>T	c.(9238-9240)Cga>Tga	p.R3080*	TRIO_ENST00000537187.1_Nonsense_Mutation_p.R2904*|TRIO_ENST00000344135.5_Nonsense_Mutation_p.R579*	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	3080					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GAATGATGTTCGACCTATCCG	0.522000													35	105					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24436349	24436349	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:24436349G>A	ENST00000383168.4	-	5	926	c.798C>T	c.(796-798)ttC>ttT	p.F266F	AQP4_ENST00000581374.1_Silent_p.F244F|AQP4_ENST00000440832.3_Silent_p.F244F|AQP4-AS1_ENST00000582605.1_RNA|AQP4_ENST00000583022.1_5'UTR|AQP4-AS1_ENST00000579964.1_RNA	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	266					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					CAGCTTTGCTGAAGGCTTCTT	0.488000													62	266					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949866	27949866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27949866G>A	ENST00000379992.2	-	6	1253	c.804C>T	c.(802-804)gcC>gcT	p.A268A	LINGO2_ENST00000308675.3_Silent_p.A268A	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	268						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		GGTGTTTAAAGGCAAGGAAGG	0.493000													19	141					0	0	1	0	0
MUS81	80198	broad.mit.edu	37	11	65632592	65632592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65632592C>T	ENST00000308110.4	+	13	1726	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	MUS81_ENST00000533035.1_Silent_p.F384F	NM_025128.4	NP_079404.3	Q96NY9	MUS81_HUMAN	MUS81 structure-specific endonuclease subunit	459					DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	13				READ - Rectum adenocarcinoma(159;0.166)		TCAGTGACTTCAACGCAGGAG	0.597000								Homologous recombination					86	190					0	0	1	0	0
ZNF540	163255	broad.mit.edu	37	19	38102515	38102515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38102515C>T	ENST00000592533.1	+	5	666	c.334C>T	c.(334-336)Cgt>Tgt	p.R112C	ZNF540_ENST00000343599.5_Missense_Mutation_p.R112C|ZNF540_ENST00000586792.1_3'UTR|ZNF540_ENST00000589117.1_Missense_Mutation_p.R80C|ZNF540_ENST00000316433.4_Missense_Mutation_p.R112C	NM_152606.4	NP_689819.1			zinc finger protein 540									p.R112C(1)		breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAAAACTCTTCGTCTGAAAGG	0.333000													25	194					0	0	1	0	0
CAPN11	11131	broad.mit.edu	37	6	44147827	44147827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44147827C>T	ENST00000542245.1	+	14	1605	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S	CAPN11_ENST00000398776.1_Missense_Mutation_p.P523S			Q9UMQ6	CAN11_HUMAN	calpain 11	523	Domain III.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TATCATTATTCCCTCCACCTT	0.552000													26	45					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92638150	92638150	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:92638150G>T	ENST00000318445.6	+	3	900	c.686G>T	c.(685-687)gGg>gTg	p.G229V	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.G229V	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	229					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CCAGCCTGCGGGTTTATCCTG	0.428000													21	99					7.92952e-12	7.96532e-12	1	1	0
TFAP4	7023	broad.mit.edu	37	16	4311934	4311934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4311934G>A	ENST00000204517.6	-	4	699	c.371C>T	c.(370-372)tCc>tTc	p.S124F		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	124					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						TCGCTTGGGGGACGAGCCGCT	0.657000											OREG0023575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	17					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22303555	22303555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22303555C>T	ENST00000337107.6	+	1	42	c.23C>T	c.(22-24)tCc>tTc	p.S8F		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	8					cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						CTGCTCAGTTCCCTCCTCCTT	0.527000													86	230					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371795	240371795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240371795C>T	ENST00000319653.9	+	5	3913	c.3683C>T	c.(3682-3684)cCt>cTt	p.P1228L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1228	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCCCTCCACCTGGGACAGGA	0.622000													15	28					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127358154	127358154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127358154C>T	ENST00000342480.6	+	2	176	c.137C>T	c.(136-138)tCc>tTc	p.S46F		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	46					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						ACCTCCACCTCCCTGCTAGAC	0.642000													18	54					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033732	82033732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82033732C>T	ENST00000328945.5	-	3	293	c.166G>A	c.(166-168)Gga>Aga	p.G56R	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	56					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CGGATGTCTCCTTGTATAAAC	0.502000													16	149					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42379582	42379582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42379582C>T	ENST00000290472.3	-	3	265	c.171G>A	c.(169-171)atG>atA	p.M57I		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	57	C2.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TCTTAAACTTCATTCCAGGTG	0.547000													56	141					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248813326	248813326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248813326G>A	ENST00000344889.3	-	1	859	c.860C>T	c.(859-861)cCa>cTa	p.P287L		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTAAATGAGTGGATTGAGCAT	0.493000													20	69					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442346	138442346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138442346G>A	ENST00000344876.4	-	4	3631	c.3245C>T	c.(3244-3246)tCt>tTt	p.S1082F	PCDH18_ENST00000412923.2_Missense_Mutation_p.S1081F|PCDH18_ENST00000507846.1_Missense_Mutation_p.S861F|PCDH18_ENST00000511115.1_Missense_Mutation_p.S262F|PCDH18_ENST00000510305.1_Missense_Mutation_p.S293F	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	1082	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					CCATTTTGAAGAAGGCTGCAC	0.512000													15	32					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110901982	110901982	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110901982G>A	ENST00000265171.5	+	15	2667	c.2221_splice	c.e15-1	p.G741_splice	EGF_ENST00000509793.1_Splice_Site_p.G699_splice|EGF_ENST00000503392.1_Splice_Site_p.G741_splice	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	741	EGF-like 5.				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TCTCTACTAGGAGCAGATCCC	0.408000													29	88					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539443	55539443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55539443G>A	ENST00000220676.1	+	4	3149	c.3001G>A	c.(3001-3003)Gaa>Aaa	p.E1001K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1001					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGACACTGGTGAAGAAGATCT	0.383000													61	189					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756644	15756644	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15756644C>T	ENST00000221307.7	+	3	362	c.314C>T	c.(313-315)aCc>aTc	p.T105I	CYP4F3_ENST00000591058.1_Intron|CYP4F3_ENST00000585846.1_Intron|CYP4F3_ENST00000586182.1_Intron	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	105					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						TTCCACCCCACCTACATCAAG	0.592000													19	34					0	0	1	0	0
C22orf29	79680	broad.mit.edu	37	22	19839242	19839242	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19839242G>A	ENST00000405640.1	-	2	1211	c.543C>T	c.(541-543)gaC>gaT	p.D181D	C22orf29_ENST00000407472.1_Silent_p.D181D|GNB1L_ENST00000329517.6_Intron|C22orf29_ENST00000328554.4_Silent_p.D181D|GNB1L_ENST00000405009.1_Intron|GNB1L_ENST00000460402.1_Intron|C22orf29_ENST00000484072.1_Intron|GNB1L_ENST00000403325.1_Intron			Q7L3V2	CV029_HUMAN	chromosome 22 open reading frame 29	181										NS(1)|large_intestine(1)|lung(3)|prostate(1)|urinary_tract(1)	7	Colorectal(54;0.0993)					AACTGTTCGGGTCTTGAACAA	0.617000													8	95					0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76828970	76828970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76828970C>T	ENST00000248598.5	-	1	173	c.141G>A	c.(139-141)ggG>ggA	p.G47G	CCDC146_ENST00000431197.1_Intron|CCDC146_ENST00000285871.4_Intron	NM_006682.2	NP_006673.1	Q14314	FGL2_HUMAN	fibrinogen-like 2	47					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						CTTCGCATTTCCCTCTGCTTT	0.493000													41	121					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74489326	74489326	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74489326G>A	ENST00000394019.2	-	11	1146	c.749C>T	c.(748-750)cCg>cTg	p.P250L	SLC4A5_ENST00000346834.4_Missense_Mutation_p.P250L|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Missense_Mutation_p.P250L|SLC4A5_ENST00000377634.4_Missense_Mutation_p.P250L|SLC4A5_ENST00000359484.4_Missense_Mutation_p.P186L|SLC4A5_ENST00000357822.5_Missense_Mutation_p.P250L|SLC4A5_ENST00000358683.4_Missense_Mutation_p.P186L|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Missense_Mutation_p.P250L	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	250						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GTGTAGACTCGGGCCAGCACC	0.587000													12	48					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66947101	66947101	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66947101C>T	ENST00000299752.4	-	9	1180	c.987G>A	c.(985-987)gaG>gaA	p.E329E	CDH16_ENST00000570262.1_Silent_p.E249E|CDH16_ENST00000568632.1_Silent_p.E232E|CDH16_ENST00000394055.3_Silent_p.E329E|CDH16_ENST00000565796.1_Silent_p.E329E	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	329	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CGTTGTCATTCTCATCCATCA	0.612000													14	136					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2298088	2298088	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2298088G>A	ENST00000381458.5	+	7	1003	c.940G>A	c.(940-942)Gac>Aac	p.D314N	TGM3_ENST00000463090.1_3'UTR	NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	314					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	TGTGTACTACGACCCCATGGG	0.517000													54	151					0	0	1	0	0
MRPL14	64928	broad.mit.edu	37	6	44081883	44081883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44081883G>A	ENST00000372014.3	-	3	266	c.135C>T	c.(133-135)gcC>gcT	p.A45A		NM_032111.2	NP_115487.2	Q6P1L8	RM14_HUMAN	mitochondrial ribosomal protein L14	45					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0181)			TGTTCCCCAGGGCACTGTTGT	0.542000													29	301					0	0	1	0	0
TREML1	340205	broad.mit.edu	37	6	41117391	41117391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41117391G>A	ENST00000426005.2	-	6	930	c.887C>T	c.(886-888)tCg>tTg	p.S296L	TREML1_ENST00000373127.4_3'UTR|TREML1_ENST00000437044.2_Missense_Mutation_p.S185L	NM_178174.2	NP_835468.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	296					calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGCCCACACGAGGTCCCTCC	0.547000													29	77					0	0	1	0	0
DMRT2	10655	broad.mit.edu	37	9	1057157	1057157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:1057157G>A	ENST00000382251.3	+	5	1899	c.1570G>A	c.(1570-1572)Gac>Aac	p.D524N	DMRT2_ENST00000302441.6_Missense_Mutation_p.D524N|DMRT2_ENST00000358146.2_Missense_Mutation_p.D524N|DMRT2_ENST00000382255.3_3'UTR|DMRT2_ENST00000259622.6_3'UTR			Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor 2	524					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)|prostate(2)	4		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		ATGTGCAAAAGACCTTTTTGT	0.393000													11	91					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142513531	142513531	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:142513531G>A	ENST00000378004.3	+	19	2053		c.e19-1		ARHGAP26_ENST00000274498.4_Splice_Site	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26						actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCGTTTGCAGATATTTAACA	0.517000													88	193					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10420095	10420095	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10420095C>T	ENST00000397077.1	-	9	1483		c.e9-1		ATP2B2_ENST00000352432.4_Splice_Site|ATP2B2_ENST00000343816.4_Splice_Site|ATP2B2_ENST00000383800.4_Splice_Site|ATP2B2_ENST00000360273.2_Splice_Site			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2						ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						TGTTGTTTGGCTGCAGGGGGC	0.632000													25	65					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116073723	116073723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116073723C>T	ENST00000369271.3	-	7	999	c.699G>A	c.(697-699)cgG>cgA	p.R233R	AFAP1L2_ENST00000545353.1_Silent_p.R286R|AFAP1L2_ENST00000304129.4_Silent_p.R233R	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	233	PH 1.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GCTCCTTCTTCCGCACTTGCT	0.567000													13	60					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52549277	52549277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52549277G>A	ENST00000242839.4	-	2	235	c.79C>T	c.(79-81)Cgt>Tgt	p.R27C	ATP7B_ENST00000418097.2_Missense_Mutation_p.R27C|ATP7B_ENST00000344297.5_Missense_Mutation_p.R27C|ATP7B_ENST00000542656.1_5'UTR|ATP7B_ENST00000448424.2_Missense_Mutation_p.R27C|ATP7B_ENST00000400370.3_Missense_Mutation_p.R27C|ATP7B_ENST00000400366.3_Missense_Mutation_p.R27C	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	27					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TCCCAGGCACGGGTAGGCAAA	0.428000									Wilson disease				16	45					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18456703	18456703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:18456703G>A	ENST00000338745.6	-	5	2273	c.539C>T	c.(538-540)cCt>cTt	p.P180L	SATB1_ENST00000454909.2_Missense_Mutation_p.P180L|SATB1_ENST00000475083.1_5'UTR|SATB1_ENST00000417717.2_Missense_Mutation_p.P180L|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	180	PDZ-like dimerization domain.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						TTGTTCGGGAGGCAAGTCTTC	0.453000													27	54					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133543152	133543152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133543152C>T	ENST00000409261.1	-	14	1605	c.1232G>A	c.(1231-1233)cGa>cAa	p.R411Q	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.R411Q	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	411							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TAACACTTTTCGCTTCTGTAG	0.413000													27	55					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8422107	8422107	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8422107G>A	ENST00000360416.3	-	21	2484	c.2346C>T	c.(2344-2346)atC>atT	p.I782I	MYH10_ENST00000379980.4_Silent_p.I767I|MYH10_ENST00000396239.1_Silent_p.I772I|MYH10_ENST00000269243.4_Silent_p.I751I	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	751	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CTAAAGCCCGGATCTAAGAGA	0.348000													28	33					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41758327	41758327	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41758327C>T	ENST00000301178.4	+	15	1973	c.1783C>T	c.(1783-1785)Ccc>Tcc	p.P595S	AXL_ENST00000593513.1_Missense_Mutation_p.P327S|AXL_ENST00000359092.3_Missense_Mutation_p.P586S	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	595	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						ATTTGACCATCCCAACGTCAT	0.567000													20	58					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087825	47087825	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:47087825G>A	ENST00000374312.1	+	3	1461	c.1042G>A	c.(1042-1044)Gag>Aag	p.E348K	NPY4R_ENST00000395716.1_Missense_Mutation_p.E348K	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		CCCCCTGGAGGAGTCGGAGCA	0.552000													17	142					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113085149	113085149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113085149C>T	ENST00000316851.7	+	7	945	c.945C>T	c.(943-945)gtC>gtT	p.V315V	NCAM1_ENST00000401611.2_Silent_p.V324V|NCAM1_ENST00000533760.1_Silent_p.V207V|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	325	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AGGAGCAGGTCACTCTTACCT	0.458000													8	21					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621303	179621303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179621303G>A	ENST00000589042.1	-	46	11124	c.10900C>T	c.(10900-10902)Cat>Tat	p.H3634Y	TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.H3463Y|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3321	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGCAGTATGGCACAACTGT	0.423000													9	61					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8100330	8100330	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:8100330G>A	ENST00000379328.3	+	3	872	c.304G>A	c.(304-306)Gcc>Acc	p.A102T	GATA3_ENST00000346208.3_Missense_Mutation_p.A102T	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	102				A -> V (in Ref. 2; CAA38877).	aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CGGCGGCAAAGCCCTGGGCAG	0.687000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						29	119					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382267	152382267	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152382267C>T	ENST00000271835.3	-	3	1353	c.1291G>A	c.(1291-1293)Gga>Aga	p.G431R	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	431					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCTGTCTCCCTGCCCTTCT	0.592000													34	70					0	0	1	0	0
AKR1C4	1109	broad.mit.edu	37	10	5258737	5258737	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5258737C>T	ENST00000380448.1	+	10	1163	c.910C>T	c.(910-912)Cga>Tga	p.R304*	AKR1C4_ENST00000263126.1_Nonsense_Mutation_p.R304*			P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	304					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	18					NADH(DB00157)	CAGAAATTATCGATATGTTGT	0.343000													6	15					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662311	99662311	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:99662311C>T	ENST00000373034.4	-	1	2960	c.1285G>A	c.(1285-1287)Ggc>Agc	p.G429S	PCDH19_ENST00000255531.7_Missense_Mutation_p.G429S|PCDH19_ENST00000420881.2_Missense_Mutation_p.G429S	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	429	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						ATGGGCACGCCGCCGTCGCGT	0.552000													12	69					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21032513	21032513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21032513C>T	ENST00000381545.3	+	11	1498	c.1279C>T	c.(1279-1281)Cct>Tct	p.P427S	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.P427S|LST3_ENST00000540229.1_Missense_Mutation_p.P427S|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.P427S|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	427					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TCTATATTTCCCTCTAATCTG	0.308000													22	54					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54535276	54535276	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54535276C>T	ENST00000566473.2	+	13	1502	c.1502C>T	c.(1501-1503)tCc>tTc	p.S501F	ANKFN1_ENST00000318698.2_Missense_Mutation_p.S501F			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	501										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						ATACCAATATCCTCATCCTCA	0.502000													35	75					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3607626	3607626	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3607626G>A	ENST00000301749.7	-	0	2472				NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TGACCAAGAGGGATCTGGCCA	0.498000													6	22					0	0	1	0	0
CSNK1E	1454	broad.mit.edu	37	22	38699191	38699191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38699191G>A	ENST00000396832.1	-	3	399	c.139C>T	c.(139-141)Ccc>Tcc	p.P47S	CSNK1E_ENST00000359867.3_Missense_Mutation_p.P47S|CSNK1E_ENST00000403904.1_Missense_Mutation_p.P47S|CSNK1E_ENST00000413574.2_Missense_Mutation_p.P47S|CSNK1E_ENST00000405675.3_Missense_Mutation_p.P47S|CSNK1E_ENST00000400206.2_Missense_Mutation_p.P47S	NM_152221.2	NP_689407.1	P49674	KC1E_HUMAN	casein kinase 1, epsilon	47	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Melanoma(58;0.045)					TGCAGCTGGGGGTGCTTTGTC	0.667000													7	13					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47548875	47548875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47548875C>T	ENST00000273859.3	+	10	1900	c.1631C>T	c.(1630-1632)cCc>cTc	p.P544L	ATP10D_ENST00000504445.1_Missense_Mutation_p.P529L	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	544					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						TTCAGTAGCCCCATTGTAAGT	0.428000													7	31					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111397755	111397755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111397755C>T	ENST00000265162.5	+	1	527	c.185C>T	c.(184-186)tCt>tTt	p.S62F		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	62					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CACCTGCCTTCTTCCACGGCC	0.637000													19	89					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424037	125424037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125424037C>T	ENST00000373686.1	+	1	193	c.193C>T	c.(193-195)Ctt>Ttt	p.L65F				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						ATTCATCCTCCTTGGACTCTC	0.448000													25	69					0	0	1	0	0
PRRG3	79057	broad.mit.edu	37	X	150869196	150869196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150869196C>T	ENST00000370353.3	+	4	777	c.387C>T	c.(385-387)ctC>ctT	p.L129L	PRRG3_ENST00000538575.1_Silent_p.L129L			Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)	129						extracellular region|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					GGCACACCCTCCCCCGGGTCA	0.652000													43	25					0	0	1	0	0
NRL	4901	broad.mit.edu	37	14	24551935	24551935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24551935G>A	ENST00000561028.1	-	2	442	c.123C>T	c.(121-123)tcC>tcT	p.S41S	NRL_ENST00000396997.1_Silent_p.S41S|NRL_ENST00000397002.2_Silent_p.S41S			P54845	NRL_HUMAN	neural retina leucine zipper	41					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding			lung(2)	2				GBM - Glioblastoma multiforme(265;0.0181)		TGTAAGGTGTGGAGCCCAGTG	0.597000													7	30					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62739651	62739651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62739651C>T	ENST00000371153.4	-	3	1503	c.1125G>A	c.(1123-1125)gaG>gaA	p.E375E	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	375										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						CTTTGATTTCCTCTTCCTGCT	0.542000													33	101					0	0	1	0	0
ASL	435	broad.mit.edu	37	7	65557757	65557757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:65557757C>T	ENST00000304874.9	+	17	1355	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	ASL_ENST00000464970.1_3'UTR|ASL_ENST00000395331.3_Missense_Mutation_p.P398L|ASL_ENST00000380839.4_Missense_Mutation_p.P392L|ASL_ENST00000395332.3_Missense_Mutation_p.P418L|AC068533.7_ENST00000450043.1_Intron	NM_000048.3	NP_000039.2	P04424	ARLY_HUMAN	argininosuccinate lyase	418					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(3)|endometrium(3)|large_intestine(2)|lung(9)|upper_aerodigestive_tract(1)	18					L-Arginine(DB00125)	CTCCCCAGCCCCCTGTTCTCG	0.687000													42	129					0	0	1	0	0
ZNF287	57336	broad.mit.edu	37	17	16466515	16466515	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:16466515G>A	ENST00000395824.1	-	5	1277	c.660C>T	c.(658-660)ccC>ccT	p.P220P	ZNF287_ENST00000395825.3_Silent_p.P220P			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	213	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CTTCCAATATGGGAATCACAG	0.368000													14	58					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48567670	48567670	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48567670G>A	ENST00000537810.1	-	29	3812	c.3208C>T	c.(3208-3210)Cgt>Tgt	p.R1070C	FRYL_ENST00000503238.1_Missense_Mutation_p.R1070C|FRYL_ENST00000358350.4_Missense_Mutation_p.R1070C|FRYL_ENST00000507711.1_Missense_Mutation_p.R1070C|FRYL_ENST00000264319.7_5'UTR			O94915	FRYL_HUMAN	FRY-like	1070					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AGACTGTGACGAAGGCTCTGT	0.353000													14	44					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35084740	35084740	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35084740C>T	ENST00000382002.5	-	5	631	c.203_splice	c.e5-1	p.E69_splice	PRLR_ENST00000513753.1_Splice_Site_p.E69_splice|PRLR_ENST00000342362.5_Intron|PRLR_ENST00000511486.1_Intron|PRLR_ENST00000542609.1_Splice_Site_p.E69_splice|PRLR_ENST00000397391.3_5'UTR|PRLR_ENST00000348262.3_Splice_Site_p.E69_splice|PRLR_ENST00000310101.5_Splice_Site_p.E69_splice|PRLR_ENST00000231423.3_Splice_Site_p.E69_splice|PRLR_ENST00000509934.1_5'UTR	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	69	Fibronectin type-III 1.				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ATGAGTGTCTCTCTGCAATAA	0.408000													22	59					0	0	1	0	0
DHRS3	9249	broad.mit.edu	37	1	12677180	12677180	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12677180G>A	ENST00000376223.2	-	1	557	c.174C>T	c.(172-174)ttC>ttT	p.F58F		NM_004753.4	NP_004744.2	O75911	DHRS3_HUMAN	dehydrogenase/reductase (SDR family) member 3	58					retinol metabolic process|visual perception	integral to membrane	electron carrier activity|NADP-retinol dehydrogenase activity|nucleotide binding			cervix(1)|large_intestine(4)|lung(2)|prostate(1)|skin(1)	9	Ovarian(185;0.249)	Lung NSC(185;4.11e-05)|all_lung(284;4.58e-05)|Renal(390;0.000147)|Colorectal(325;0.000585)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;9.25e-07)|COAD - Colon adenocarcinoma(227;0.000326)|BRCA - Breast invasive adenocarcinoma(304;0.000344)|Kidney(185;0.00235)|KIRC - Kidney renal clear cell carcinoma(229;0.00656)|STAD - Stomach adenocarcinoma(313;0.00798)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	CGCGCTCCGCGAACTCGCGGG	0.731000													26	49					0	0	1	0	0
DDO	8528	broad.mit.edu	37	6	110714215	110714215	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110714215G>A	ENST00000368924.3	-	5	888	c.873C>T	c.(871-873)ccC>ccT	p.P291P	DDO_ENST00000368923.3_Silent_p.P232P|DDO_ENST00000368925.1_Silent_p.P263P	NM_003649.2	NP_003640.2	Q99489	OXDD_HUMAN	D-aspartate oxidase	263					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|pancreas(1)|skin(3)	24		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		CGTGGAGGGAGGGCTCCAGAG	0.572000													57	102					0	0	1	0	0
ZNF890P	645700	broad.mit.edu	37	7	5167360	5167360	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5167360G>A	ENST00000422060.2	-	0	491					NR_034163.1																						CCACGTCCCCGAATGACAGTG	0.557000													4	16					0	0	1	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50405101	50405101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50405101C>T	ENST00000435965.1	-	27	2463	c.2290G>A	c.(2290-2292)Ggt>Agt	p.G764S	XXcos-LUCA11.4_ENST00000607362.1_RNA|XXcos-LUCA11.4_ENST00000607088.1_RNA|CACNA2D2_ENST00000423994.2_Missense_Mutation_p.G764S|CACNA2D2_ENST00000429770.1_Missense_Mutation_p.G757S|CACNA2D2_ENST00000424201.2_Missense_Mutation_p.G757S|XXcos-LUCA11.5_ENST00000606589.1_Intron|XXcos-LUCA11.4_ENST00000606665.1_RNA|XXcos-LUCA11.4_ENST00000606259.1_RNA|CACNA2D2_ENST00000266039.3_Missense_Mutation_p.G757S|CACNA2D2_ENST00000479441.1_Missense_Mutation_p.G764S|CACNA2D2_ENST00000395083.1_Missense_Mutation_p.G757S|XXcos-LUCA11.4_ENST00000607121.1_RNA|CACNA2D2_ENST00000360963.3_Missense_Mutation_p.G688S			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	764					energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	GTGATGCCACCGTCTGTGGCA	0.642000													19	36					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640122	179640122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179640122C>T	ENST00000589042.1	-	28	6693	c.6469G>A	c.(6469-6471)Gct>Act	p.A2157T	TTN_ENST00000342992.6_Missense_Mutation_p.A2157T|TTN_ENST00000360870.5_Missense_Mutation_p.A2157T|TTN_ENST00000460472.2_Missense_Mutation_p.A2111T|TTN_ENST00000342175.6_Missense_Mutation_p.A2111T|TTN_ENST00000359218.5_Missense_Mutation_p.A2111T|TTN_ENST00000591111.1_Missense_Mutation_p.A2157T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1918	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTCTCCAGCTATGTTGATG	0.433000													18	73					0	0	1	0	0
DEFB1	1672	broad.mit.edu	37	8	6728337	6728337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:6728337G>A	ENST00000297439.3	-	2	237	c.73C>T	c.(73-75)Ctc>Ttc	p.L25F		NM_005218.3	NP_005209.1	P60022	DEFB1_HUMAN	defensin, beta 1	25					chemotaxis|defense response to bacterium|G-protein coupled receptor protein signaling pathway|innate immune response	extracellular region				lung(1)	1			STAD - Stomach adenocarcinoma(24;0.0984)	COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.128)		AGGCCTGTGAGAAAGTTACCA	0.468000													12	35					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233507881	233507881	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233507881G>A	ENST00000366624.3	+	6	1911	c.1650G>A	c.(1648-1650)atG>atA	p.M550I	MLK4_ENST00000366623.3_Missense_Mutation_p.M550I	NM_032435.2	NP_115811.2																					GCCCCACAATGATGCCCCGAC	0.557000													31	80					0	0	1	0	0
C8orf31	286122	broad.mit.edu	37	8	144126224	144126224	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144126224G>A	ENST00000395172.1	+	4	697	c.345G>A	c.(343-345)gaG>gaA	p.E115E	C8orf31_ENST00000517653.1_3'UTR	NM_173687.2	NP_775958.1	Q8N9H6	CH031_HUMAN	chromosome 8 open reading frame 31	115										breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGAGCTGGGAGAGAGGGCAAG	0.622000													9	14					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72198665	72198665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72198665G>A	ENST00000537465.1	-	3	321	c.163C>T	c.(163-165)Cac>Tac	p.H55Y	PMFBP1_ENST00000355636.6_5'UTR|PMFBP1_ENST00000543746.1_5'UTR|PMFBP1_ENST00000237353.10_Missense_Mutation_p.H55Y			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	55										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TCCCTTACGTGGCTGCTGTTC	0.522000													9	89					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139741513	139741513	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139741513G>A	ENST00000263549.3	-	6	1986	c.1113C>T	c.(1111-1113)ttC>ttT	p.F371F	PARP12_ENST00000470515.1_5'UTR	NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	371	WWE 2.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					TGGTGAGGATGAAGTGTGGAG	0.498000													42	199					0	0	1	0	0
C5orf28	64417	broad.mit.edu	37	5	43446355	43446355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:43446355G>A	ENST00000500337.2	-	5	948	c.617C>T	c.(616-618)tCt>tTt	p.S206F	C5orf28_ENST00000537319.1_Missense_Mutation_p.S75F|C5orf28_ENST00000397080.3_Missense_Mutation_p.S206F|C5orf28_ENST00000512085.1_Missense_Mutation_p.S206F|C5orf28_ENST00000511525.1_5'UTR|C5orf28_ENST00000510130.1_Missense_Mutation_p.S104F			Q0VDI3	CE028_HUMAN	chromosome 5 open reading frame 28	206						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(5)	9	Lung NSC(6;2.07e-05)					ATGTTTTGAAGACATCATTTG	0.368000													12	68					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85399823	85399823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85399823G>A	ENST00000258888.5	+	6	2627	c.2460G>A	c.(2458-2460)gtG>gtA	p.V820V		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	820					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGATACAAGTGGATGGAAGGA	0.522000													16	78					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157041160	157041160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157041160C>T	ENST00000348165.5	+	19	2940	c.2580C>T	c.(2578-2580)gcC>gcT	p.A860A		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	860	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		ACCACCTCGCCTCCCTAGACC	0.512000													21	173					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8234961	8234961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8234961C>T	ENST00000339754.5	+	1	155	c.77C>T	c.(76-78)gCc>gTc	p.A26V		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	26					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		CCGCCCCGGGCCTCCAACCGC	0.637000													5	23					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16315466	16315466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16315466G>A	ENST00000575728.1	-	2	291	c.259C>T	c.(259-261)Cgg>Tgg	p.R87W	ABCC6_ENST00000205557.7_Intron|ABCC6_ENST00000574094.1_Intron	NM_001079528.3	NP_001072996.1	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0					response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TGCCTCCCCCGAACATTGCCT	0.542000													6	17					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10756116	10756116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10756116G>A	ENST00000416569.2	-	3	1298	c.1272C>T	c.(1270-1272)atC>atT	p.I424I	XKR6_ENST00000304437.2_Silent_p.I145I	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	424						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		AAATGTACACGATCCCTACCA	0.493000													12	22					0	0	1	0	0
PDZD4	57595	broad.mit.edu	37	X	153072226	153072226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153072226C>T	ENST00000164640.4	-	4	648	c.457G>A	c.(457-459)Gag>Aag	p.E153K	PDZD4_ENST00000393758.2_Missense_Mutation_p.E78K|PDZD4_ENST00000475140.1_5'UTR|PDZD4_ENST00000544474.1_Missense_Mutation_p.E44K	NM_032512.2	NP_115901.2	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	153	PDZ.					cell cortex				breast(3)|cervix(1)|endometrium(5)|lung(13)|skin(1)	23	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGGTCCTCCTCGTCGTCCGTG	0.632000													7	48					0	0	1	0	0
CGREF1	10669	broad.mit.edu	37	2	27324423	27324423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27324423C>T	ENST00000402394.1	-	6	944	c.676G>A	c.(676-678)Gag>Aag	p.E226K	CGREF1_ENST00000452318.2_Intron|CGREF1_ENST00000260595.5_Missense_Mutation_p.E226K|CGREF1_ENST00000404694.3_Missense_Mutation_p.E348K|CGREF1_ENST00000312734.4_Missense_Mutation_p.E226K|CGREF1_ENST00000402550.1_Intron|CGREF1_ENST00000405600.1_Missense_Mutation_p.E226K	NM_006569.5	NP_006560.3	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	226					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			kidney(1)|lung(4)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCTGGCCCTCAGCTTCCCCT	0.672000													133	270					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78440599	78440599	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78440599C>T	ENST00000278550.7	-	22	3690	c.3228G>A	c.(3226-3228)agG>agA	p.R1076R		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TGAGGCTGATCCTCAGGACAG	0.582000													20	47					0	0	1	0	0
ZDHHC23	254887	broad.mit.edu	37	3	113672617	113672617	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113672617C>T	ENST00000330212.3	+	3	531	c.232C>T	c.(232-234)Cga>Tga	p.R78*	ZDHHC23_ENST00000498275.1_Nonsense_Mutation_p.R72*	NM_173570.3	NP_775841.2	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC-type containing 23	78						integral to membrane	acyltransferase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|urinary_tract(2)	16						TGATCGCCTCCGAATTCCTTG	0.453000													47	113					0	0	1	0	0
FGF3	2248	broad.mit.edu	37	11	69625426	69625426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:69625426C>T	ENST00000334134.2	-	3	457	c.367G>A	c.(367-369)Gag>Aag	p.E123K		NM_005247.2	NP_005238.1	P11487	FGF3_HUMAN	fibroblast growth factor 3	123					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of cardiac muscle tissue development|positive regulation of cell division|positive regulation of cell proliferation	extracellular region	growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|urinary_tract(1)	13			LUSC - Lung squamous cell carcinoma(11;5.05e-15)|STAD - Stomach adenocarcinoma(18;0.0278)			TAGCCCAGCTCGTGGATCCGC	0.647000													20	69					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128491636	128491636	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128491636C>T	ENST00000325888.8	+	35	6057	c.5796C>T	c.(5794-5796)ttC>ttT	p.F1932F	FLNC_ENST00000346177.6_Silent_p.F1899F|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1932					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TCGTGCGCTTCGATGACAAGC	0.577000													29	70					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916742	42916742	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42916742C>T	ENST00000316161.4	-	1	891	c.567G>A	c.(565-567)acG>acA	p.T189T	ACKR2_ENST00000471537.1_Intron|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Silent_p.T189T	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	189					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CCTTGTCCTTCGTGTAGCCGA	0.522000													17	80					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28968350	28968350	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28968350G>A	ENST00000359747.4	+	4	266	c.237G>A	c.(235-237)tcG>tcA	p.S79S	DSG4_ENST00000308128.4_Silent_p.S79S|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	79	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACTGCGAATCGAACCAGAAGA	0.413000													21	57					0	0	1	0	0
DCAF11	80344	broad.mit.edu	37	14	24590594	24590594	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24590594C>T	ENST00000446197.3	+	13	1994	c.1267C>T	c.(1267-1269)Cca>Tca	p.P423S	DCAF11_ENST00000396941.4_Missense_Mutation_p.P397S|DCAF11_ENST00000396936.1_Missense_Mutation_p.P323S|RP11-468E2.6_ENST00000558325.1_Missense_Mutation_p.P12L|DCAF11_ENST00000559115.1_Missense_Mutation_p.P423S	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11	423						CUL4 RING ubiquitin ligase complex	protein binding										GCTGAAGCTCCCAGGGGACAG	0.572000													43	110					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108156452	108156452	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108156452C>T	ENST00000273353.3	-	26	3286	c.3230G>A	c.(3229-3231)aGt>aAt	p.S1077N		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1077						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GTTCTCCATACTTTCCCGATT	0.483000													53	205					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101731860	101731860	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101731860G>A	ENST00000342239.3	-	2	113	c.22C>T	c.(22-24)Cga>Tga	p.R8*	DNMBP_ENST00000324109.4_Nonsense_Mutation_p.R8*			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	8	SH3 1.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		AAAATGGCTCGAACCACTGAG	0.403000													29	103					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204955233	204955233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204955233C>T	ENST00000367172.4	+	23	3110	c.2782C>T	c.(2782-2784)Ccg>Tcg	p.P928S	NFASC_ENST00000404076.1_Missense_Mutation_p.P907S|NFASC_ENST00000513543.1_Missense_Mutation_p.P924S|NFASC_ENST00000367171.4_Missense_Mutation_p.P913S|NFASC_ENST00000339876.6_Intron|NFASC_ENST00000539706.1_Missense_Mutation_p.P924S|NFASC_ENST00000404907.1_Missense_Mutation_p.P924S|NFASC_ENST00000360049.4_Missense_Mutation_p.P924S|NFASC_ENST00000367170.4_Missense_Mutation_p.P928S|NFASC_ENST00000401399.1_Intron|NFASC_ENST00000367169.4_Intron|NFASC_ENST00000338586.6_Missense_Mutation_p.P928S|NFASC_ENST00000338515.6_Missense_Mutation_p.P928S			O94856	NFASC_HUMAN	neurofascin	928					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GTTCACCACCCCGGAAGGAGG	0.602000													9	30					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25272796	25272796	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25272796C>T	ENST00000218548.6	+	12	1864	c.1530_splice	c.e12-1	p.L511_splice	ATP12A_ENST00000381946.3_Splice_Site_p.L505_splice	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	505					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TCCTTCCCAGCTCTCCATCCA	0.507000													23	41					0	0	1	0	0
ARFIP1	27236	broad.mit.edu	37	4	153791994	153791994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:153791994C>T	ENST00000451320.2	+	4	456	c.292C>T	c.(292-294)Cct>Tct	p.P98S	ARFIP1_ENST00000356064.3_Intron|ARFIP1_ENST00000511289.1_3'UTR|ARFIP1_ENST00000429148.2_Intron|ARFIP1_ENST00000353617.2_Missense_Mutation_p.P98S|ARFIP1_ENST00000405727.2_Intron			P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	98					intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane			ARFIP1/FHDC1(2)	cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(180;0.093)					TTTAATTGTTCCTGCAGGTAT	0.433000													28	42					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2942488	2942488	+	Missense_Mutation	SNP	G	G	A	rs145270510	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:2942488G>A	ENST00000397461.1	+	10	1444	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	CNTN4_ENST00000418658.1_Missense_Mutation_p.E354K|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000448906.2_Missense_Mutation_p.E26K|CNTN4_ENST00000358480.3_Missense_Mutation_p.E135K|CNTN4_ENST00000397459.2_Missense_Mutation_p.E26K|CNTN4_ENST00000427331.1_Missense_Mutation_p.E354K	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	354	Ig-like C2-type 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AAAAAATGGCGAACCTCTGCT	0.398000													29	79					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238049074	238049074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:238049074C>T	ENST00000366570.4	-	7	1110	c.952G>A	c.(952-954)Gaa>Aaa	p.E318K	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	318	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ATCTGAAGTTCCAGAGTGAGG	0.502000													8	48					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76744936	76744936	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76744936C>T	ENST00000287239.4	+	12	2961	c.2472C>T	c.(2470-2472)ttC>ttT	p.F824F	KAT6B_ENST00000372714.1_Silent_p.F532F|KAT6B_ENST00000372725.1_Silent_p.F532F|KAT6B_ENST00000490365.1_3'UTR|KAT6B_ENST00000372724.1_Silent_p.F532F|KAT6B_ENST00000372711.1_Silent_p.F641F	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	824	Catalytic.|Interaction with BRPF1.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										TCGAGCCATTCCTTTTTTATG	0.378000													12	82					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306200	54306200	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54306200G>A	ENST00000545554.1	+	1	1100	c.1100G>A	c.(1099-1101)aGa>aAa	p.R367K	UNC13C_ENST00000537900.1_Missense_Mutation_p.R367K|UNC13C_ENST00000260323.11_Missense_Mutation_p.R367K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	367					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGACACCAGAGAGACTGCCCA	0.383000													5	66					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25457049	25457049	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25457049G>A	ENST00000424208.1	+	0	2516				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						ATTTGGAGGAGGATGCTGGGA	0.507000													107	208					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28540813	28540813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28540813C>T	ENST00000452236.2	-	4	3470	c.2853G>A	c.(2851-2853)aaG>aaA	p.K951K		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	951					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						caatataattctttacagctt	0.343000													13	34					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	136974658	136974658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:136974658G>A	ENST00000508657.1	-	10	1821	c.1107C>T	c.(1105-1107)ggC>ggT	p.G369G	KLHL3_ENST00000506873.1_5'UTR|KLHL3_ENST00000506491.1_Silent_p.G319G|KLHL3_ENST00000309755.4_Silent_p.G401G|KLHL3_ENST00000541417.1_Intron	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	401						cytoplasm|cytoskeleton	actin binding|structural molecule activity	p.G401G(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		TGCCATCAAAGCCTCCCACTG	0.582000													8	21					0	0	1	0	0
BHMT2	23743	broad.mit.edu	37	5	78379618	78379618	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78379618G>A	ENST00000255192.3	+	7	1015	c.949G>A	c.(949-951)Gaa>Aaa	p.E317K	DMGDH_ENST00000520388.1_Intron|BHMT2_ENST00000521567.1_Missense_Mutation_p.E253K	NM_017614.4	NP_060084.2	Q9H2M3	BHMT2_HUMAN	betaine--homocysteine S-methyltransferase 2	317					methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(8)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	15		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	ACCAGCTTCAGAAAAACACGG	0.478000													18	29					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102476636	102476636	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102476636C>T	ENST00000360184.4	+	31	6409	c.6245C>T	c.(6244-6246)tCc>tTc	p.S2082F		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2082	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CAGCTCTCTTCCCAAAGCCAT	0.408000													18	89					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81864669	81864669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81864669C>T	ENST00000555447.1	-	3	470	c.58G>A	c.(58-60)Gaa>Aaa	p.E20K	STON2_ENST00000267540.2_Missense_Mutation_p.E20K	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	20					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GGTGGCTCTTCATTGAAGGAG	0.483000													18	48					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86772975	86772975	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:86772975C>T	ENST00000373119.4	+	1	224	c.79C>T	c.(79-81)Caa>Taa	p.Q27*	KLHL4_ENST00000373114.4_Nonsense_Mutation_p.Q27*	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	27						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TCATCCTTTTCAAGGTTCCAC	0.493000													46	22					0	0	1	0	0
ATG4C	84938	broad.mit.edu	37	1	63282323	63282323	+	Missense_Mutation	SNP	C	C	T	rs146646910		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:63282323C>T	ENST00000317868.4	+	4	445	c.238C>T	c.(238-240)Cgt>Tgt	p.R80C	ATG4C_ENST00000371120.3_Missense_Mutation_p.R80C	NM_032852.3	NP_116241.2	Q96DT6	ATG4C_HUMAN	autophagy related 4C, cysteine peptidase	80					autophagic vacuole assembly|protein targeting to membrane|proteolysis	cytosol|extracellular region	cysteine-type endopeptidase activity		ATG4C/FBXO38(2)	NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(3)|ovary(1)|prostate(2)	19						AGAAGAATTTCGTAAAGATTT	0.398000													8	88					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55198609	55198609	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55198609G>A	ENST00000340465.2	+	3	269	c.183G>A	c.(181-183)agG>agA	p.R61R		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	61						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCAAGATGAGGAATTCATCAT	0.358000													56	143					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41648595	41648595	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41648595C>T	ENST00000313860.7	+	12	1404	c.1350C>T	c.(1348-1350)ttC>ttT	p.F450F	LIMCH1_ENST00000381753.4_Silent_p.F284F|LIMCH1_ENST00000513024.1_Silent_p.F279F|LIMCH1_ENST00000508501.1_Silent_p.F450F|LIMCH1_ENST00000512946.1_Silent_p.F450F|LIMCH1_ENST00000509277.1_Silent_p.F284F|LIMCH1_ENST00000511496.1_Silent_p.F291F|LIMCH1_ENST00000512820.1_Silent_p.F438F|LIMCH1_ENST00000503057.1_Silent_p.F835F|LIMCH1_ENST00000512632.1_Silent_p.F450F|LIMCH1_ENST00000514096.1_Silent_p.F291F|LIMCH1_ENST00000396595.3_Silent_p.F296F	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	450					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TTGAGAGGTTCACCATCAGTG	0.493000													54	182					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324482	152324482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152324482C>T	ENST00000388718.5	-	3	5852	c.5780G>A	c.(5779-5781)gGa>gAa	p.G1927E	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1927							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGGTATCTCCTGTCTGTCC	0.502000													101	245					0	0	1	0	0
RPUSD2	27079	broad.mit.edu	37	15	40866204	40866204	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40866204C>T	ENST00000315616.7	+	3	1420	c.1382C>T	c.(1381-1383)gCc>gTc	p.A461V	RPUSD2_ENST00000559271.1_Missense_Mutation_p.A400V	NM_152260.1	NP_689473.1	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing 2	461	Poly-Ala.				pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			kidney(4)|lung(4)|skin(3)	11		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		GCTGCAGCTGCCCAGAAGATG	0.552000													29	89					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445619	49445619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49445619G>A	ENST00000301067.7	-	10	1846	c.1847C>T	c.(1846-1848)cCc>cTc	p.P616L		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGGGGAAAGGGGAGACTCCTC	0.602000													17	70					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7565753	7565753	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7565753C>T	ENST00000379802.3	+	7	1280	c.939_splice	c.e7+1	p.S313_splice	DSP_ENST00000418664.2_Splice_Site_p.S313_splice	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	313	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGGCCTTCTCCGTAAGTTCAC	0.517000													15	45					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58491601	58491601	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58491601G>A	ENST00000357552.3	-	8	678	c.453C>T	c.(451-453)ttC>ttT	p.F151F	SYCP2_ENST00000371001.2_Silent_p.F151F			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	151					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			TGCGAGGTACGAAACTTTCCA	0.294000													7	77					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31901501	31901501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31901501C>T	ENST00000456570.1	+	3	426	c.371C>T	c.(370-372)tCt>tTt	p.S124F	CFB_ENST00000477310.1_Intron|C2_ENST00000442278.2_Missense_Mutation_p.S54F|C2_ENST00000452323.2_Missense_Mutation_p.S63F|C2_ENST00000469372.1_Missense_Mutation_p.L18F|C2_ENST00000299367.5_Missense_Mutation_p.S186F|CFB_ENST00000556679.1_Missense_Mutation_p.S124F|C2_ENST00000418949.2_Missense_Mutation_p.S186F			P00751	CFAB_HUMAN	complement factor B	200	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CTCACGGGGTCTTCGGAGCGG	0.637000													20	59					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088099	86088099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:86088099C>T	ENST00000330753.4	+	2	1008	c.241C>T	c.(241-243)Cct>Tct	p.P81S	FLRT2_ENST00000554746.1_Missense_Mutation_p.P81S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	81					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGCTGGATTTCCTGCAGAACT	0.488000													29	84					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893702	36893702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36893702C>T	ENST00000301807.6	-	13	4799	c.2902G>A	c.(2902-2904)Gac>Aac	p.D968N	TRANK1_ENST00000429976.2_Missense_Mutation_p.D1518N|TRANK1_ENST00000428977.2_Missense_Mutation_p.D968N	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1518					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ATTGCCAAGTCGCTTACACTA	0.428000													10	53					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124393367	124393367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124393367G>A	ENST00000360013.3	+	49	7226	c.7099G>A	c.(7099-7101)Gac>Aac	p.D2367N	KALRN_ENST00000393496.1_Missense_Mutation_p.D707N|KALRN_ENST00000459915.1_Missense_Mutation_p.D458N|KALRN_ENST00000291478.4_Missense_Mutation_p.D670N|KALRN_ENST00000428018.2_Missense_Mutation_p.D638N	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2366	SH3 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCCTGCCAGCGACCATTCCCC	0.597000													9	18					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335551	20335551	+	Missense_Mutation	SNP	G	G	A	rs140222432		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20335551G>A	ENST00000302555.5	-	3	271	c.122C>T	c.(121-123)tCg>tTg	p.S41L	GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.S41L|GP2_ENST00000341642.5_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	41						anchored to membrane|extracellular region|plasma membrane		p.S41L(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CAGCCCATACGAACTGGCTTC	0.532000													25	37					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553899	140553899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140553899G>A	ENST00000231137.3	+	1	1657	c.1483G>A	c.(1483-1485)Gac>Aac	p.D495N		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		495	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCGTCCCAGGACCCGCACCT	0.662000													49	162					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53227586	53227586	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53227586G>A	ENST00000330553.5	-	1	493	c.459C>T	c.(457-459)ttC>ttT	p.F153F		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	153	Coil 1A.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGAAGGAGGCGAACTTGTTGT	0.607000													68	185					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38950815	38950815	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38950815G>A	ENST00000357387.3	-	31	3165	c.3135C>T	c.(3133-3135)ttC>ttT	p.F1045F	RICTOR_ENST00000296782.5_Silent_p.F1045F	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1045	Ser-rich.				actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					CCTCCAATATGAACATACCTA	0.333000													29	66					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12144525	12144525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12144525G>A	ENST00000263932.2	+	2	290	c.68G>A	c.(67-69)cGa>cAa	p.R23Q	TNFRSF8_ENST00000417814.2_Intron	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	23					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCAGGATCGACCCTTCGAG	0.597000													10	104					0	0	1	0	0
MYRIP	25924	broad.mit.edu	37	3	40231823	40231823	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:40231823G>A	ENST00000302541.6	+	10	1876	c.1534G>A	c.(1534-1536)Gag>Aag	p.E512K	MYRIP_ENST00000539167.1_Missense_Mutation_p.E325K|MYRIP_ENST00000444716.1_Missense_Mutation_p.E512K|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000396217.3_Missense_Mutation_p.E423K|MYRIP_ENST00000425621.1_Missense_Mutation_p.E512K	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	512	Actin-binding.|Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GGACAGCAGCGAGCCGGAGGA	0.647000													34	73					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36216190	36216190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36216190C>T	ENST00000222270.7	+	11	3598	c.3598C>T	c.(3598-3600)Ccc>Tcc	p.P1200S	WBP7_ENST00000420124.1_Missense_Mutation_p.P1200S|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					GCCAGGGGGCCCCCCGATGGT	0.597000													11	20					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6594260	6594260	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6594260C>T	ENST00000433363.2	-	10	1509		c.e10-1		SLC13A5_ENST00000381074.4_Splice_Site|SLC13A5_ENST00000573648.1_Splice_Site|SLC13A5_ENST00000293800.6_Splice_Site	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5							integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						GCCCCGAGGCCTGGGAAGCAC	0.642000													35	36					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23292929	23292929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:23292929G>A	ENST00000358689.4	-	11	1671	c.1436C>T	c.(1435-1437)tCt>tTt	p.S479F	ENTPD4_ENST00000356206.6_Missense_Mutation_p.S471F|ENTPD4_ENST00000521321.1_5'UTR|ENTPD4_ENST00000417069.2_Missense_Mutation_p.S471F	NM_001128930.2|NM_004901.4	NP_001122402.1|NP_004892.1	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	479					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		GTCAGCATGAGAGGCGTACAG	0.478000													7	29					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325159	31325159	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31325159C>T	ENST00000269197.5	+	12	5347	c.5347C>T	c.(5347-5349)Caa>Taa	p.Q1783*		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1783					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ATTGCCTCTTCAAACTACCTC	0.512000													20	51					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140588852	140588852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140588852G>A	ENST00000239450.2	+	1	562	c.373G>A	c.(373-375)Gat>Aat	p.D125N	PCDHB12_ENST00000541609.1_Intron	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		125	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCAGGTCAGGGATATAAATGA	0.443000													61	143					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50367249	50367249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50367249C>T	ENST00000331340.3	+	3	211	c.56C>T	c.(55-57)cCt>cTt	p.P19L	IKZF1_ENST00000413698.1_Missense_Mutation_p.P19L|IKZF1_ENST00000359197.5_Missense_Mutation_p.P19L|IKZF1_ENST00000343574.5_Missense_Mutation_p.P19L|IKZF1_ENST00000440768.2_Missense_Mutation_p.P19L|IKZF1_ENST00000346667.4_Missense_Mutation_p.P19L|IKZF1_ENST00000492782.1_3'UTR|IKZF1_ENST00000438033.1_Missense_Mutation_p.P19L|IKZF1_ENST00000357364.4_Missense_Mutation_p.P19L|IKZF1_ENST00000349824.4_Missense_Mutation_p.P19L|IKZF1_ENST00000439701.1_Missense_Mutation_p.P19L	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	19					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(33)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GAAAGCCCCCCTGTAAGCGAT	0.597000			"""D,T"""	BCL6	"""ALL, DLBCL"""								5	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179486595	179486595	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179486595C>T	ENST00000589042.1	-	244	45278	c.45054G>A	c.(45052-45054)gcG>gcA	p.A15018A	TTN_ENST00000342992.6_Silent_p.A12450A|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Silent_p.A5953A|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.A6145A|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Silent_p.A6078A|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.A13377A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13377	Fibronectin type-III 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAAGTTCTCGCTGTCCTTA	0.378000													19	35					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702748	30702748	+	Silent	SNP	C	C	T	rs112301482		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30702748C>T	ENST00000256246.2	-	1	3860	c.3786G>A	c.(3784-3786)gcG>gcA	p.A1262A		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1262								p.A1262A(1)		NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CGTCAGTTTTCGCCTTTGTGT	0.313000													14	73					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44069433	44069433	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44069433C>T	ENST00000359947.4	+	16	2950	c.2610C>T	c.(2608-2610)ttC>ttT	p.F870F	PTPRF_ENST00000422171.2_Silent_p.F218F|PTPRF_ENST00000438120.1_Silent_p.F861F|PTPRF_ENST00000372414.3_Silent_p.F870F|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372413.3_Silent_p.F861F	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	870	Fibronectin type-III 6.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCATAGATTTCGGCAAGGATG	0.637000													21	73					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139839014	139839014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139839014G>A	ENST00000303045.6	-	6	1302	c.856C>T	c.(856-858)Ccc>Tcc	p.P286S	COL22A1_ENST00000435777.1_Missense_Mutation_p.P286S	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	286	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AAACCTTGGGGGAACACATCC	0.522000										HNSCC(7;0.00092)			5	41					0	0	1	0	0
INSL5	10022	broad.mit.edu	37	1	67263912	67263912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:67263912G>A	ENST00000304526.2	-	2	226	c.192C>T	c.(190-192)tcC>tcT	p.S64S		NM_005478.4	NP_005469.2	Q9Y5Q6	INSL5_HUMAN	insulin-like 5	64						extracellular region	hormone activity			breast(2)|endometrium(1)|lung(5)	8						GGAGCTGGAAGGAGTTTCCTG	0.478000													19	76					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178392827	178392827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178392827G>A	ENST00000320129.3	+	5	1725	c.1422G>A	c.(1420-1422)gaG>gaA	p.E474E	ZNF454_ENST00000519564.1_Silent_p.E474E	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		AAATCTGTGAGAAAGCCTTTA	0.383000													48	84					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21108367	21108367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21108367C>T	ENST00000377122.4	-	20	2437	c.2041G>A	c.(2041-2043)Gag>Aag	p.E681K	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	681					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CTCAGCTGCTCCTGGTTTCGC	0.428000													84	153					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156638365	156638365	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156638365G>A	ENST00000296518.7	+	8	1836	c.1627G>A	c.(1627-1629)Gat>Aat	p.D543N	GUCY1A3_ENST00000511108.1_Missense_Mutation_p.D543N|GUCY1A3_ENST00000455639.2_Missense_Mutation_p.D543N|GUCY1A3_ENST00000513574.1_Missense_Mutation_p.D543N|GUCY1A3_ENST00000393832.3_Missense_Mutation_p.D285N|GUCY1A3_ENST00000511507.1_Missense_Mutation_p.D543N|GUCY1A3_ENST00000506455.1_Missense_Mutation_p.D543N			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	543	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CAAAGAGAGTGATACTCATGC	0.433000													19	90					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396866	154396866	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154396866G>A	ENST00000435029.4	+	1	3607	c.3447G>A	c.(3445-3447)gaG>gaA	p.E1149E		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1149	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATCCTACCGAGGTGACCCCAG	0.527000													35	59					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397806	125397806	+	Missense_Mutation	SNP	G	G	A	rs143365567		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125397806G>A	ENST00000536769.1	-	1	2088	c.512C>T	c.(511-513)cCc>cTc	p.P171L	UBC_ENST00000538617.1_Intron|UBC_ENST00000546120.1_Intron|UBC_ENST00000339647.5_Missense_Mutation_p.P171L			P0CG48	UBC_HUMAN	ubiquitin C	171	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGTGTCACTGGGCTCCACCTC	0.517000													24	198					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77343191	77343191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77343191G>A	ENST00000451710.3	-	37	6148	c.5911C>T	c.(5911-5913)Cat>Tat	p.H1971Y	TRPM6_ENST00000449912.2_Missense_Mutation_p.H1962Y|TRPM6_ENST00000360774.1_Missense_Mutation_p.H1967Y|TRPM6_ENST00000376871.3_Missense_Mutation_p.H804Y|TRPM6_ENST00000361255.3_Missense_Mutation_p.H1962Y|TRPM6_ENST00000376872.3_Missense_Mutation_p.H922Y			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1967	Alpha-type protein kinase.				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GAGTTACAATGATGTTTTGCA	0.398000													20	62					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62903542	62903542	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:62903542C>T	ENST00000512091.1	+	23	4228	c.3481C>T	c.(3481-3483)Cga>Tga	p.R1161*	LPHN3_ENST00000507164.1_Nonsense_Mutation_p.R1220*|LPHN3_ENST00000506746.1_Nonsense_Mutation_p.R1220*|LPHN3_ENST00000514591.1_Nonsense_Mutation_p.R1161*|LPHN3_ENST00000545650.1_Nonsense_Mutation_p.R1161*|LPHN3_ENST00000508693.1_Nonsense_Mutation_p.R1229*|LPHN3_ENST00000504896.1_Nonsense_Mutation_p.R1161*|LPHN3_ENST00000514996.1_Nonsense_Mutation_p.R1152*|LPHN3_ENST00000511324.1_Nonsense_Mutation_p.R1220*|LPHN3_ENST00000507625.1_Nonsense_Mutation_p.R1220*|LPHN3_ENST00000509896.1_Nonsense_Mutation_p.R1229*|LPHN3_ENST00000508946.1_Nonsense_Mutation_p.R1161*|LPHN3_ENST00000506720.1_Nonsense_Mutation_p.R1229*|LPHN3_ENST00000506700.1_Nonsense_Mutation_p.R1152*|LPHN3_ENST00000514157.1_Nonsense_Mutation_p.R1152*			Q9HAR2	LPHN3_HUMAN	latrophilin 3	1139					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						ATCTGGTTCTCGAACTCCTGG	0.428000													30	72					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70964210	70964210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70964210G>A	ENST00000357250.6	-	25	1846	c.1688C>T	c.(1687-1689)cCt>cTt	p.P563L	COL9A1_ENST00000370499.4_Missense_Mutation_p.P320L|COL9A1_ENST00000320755.7_Missense_Mutation_p.P320L|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	563	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						ATCACCAGGAGGCCCAGGTTT	0.388000													8	70					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34888231	34888231	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34888231C>T	ENST00000360581.1	+	8	1109	c.981C>T	c.(979-981)ccC>ccT	p.P327P	NPSR1_ENST00000381542.1_Silent_p.P261P|NPSR1_ENST00000381539.3_Silent_p.P327P|NPSR1_ENST00000359791.1_Silent_p.P327P|NPSR1_ENST00000531252.1_Silent_p.P316P	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	327						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CCATCAACCCCCTCATCTACT	0.502000													44	152					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131878824	131878824	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131878824G>A	ENST00000359827.3	-	14	3815	c.2853C>T	c.(2851-2853)ttC>ttT	p.F951F	PLXNA4_ENST00000321063.4_Silent_p.F951F			Q9HCM2	PLXA4_HUMAN	plexin A4	951	IPT/TIG 1.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GACTCACCATGAAGTAATAGA	0.592000													14	51					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	819602	819602	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:819602G>A	ENST00000293892.3	-	16	2987	c.2988C>T	c.(2986-2988)ccC>ccT	p.P996P	MSLNL_ENST00000442466.1_Silent_p.P645P			Q96KJ4	MSLNL_HUMAN	mesothelin-like	645					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CCATCGCCAGGGGCAGGTACC	0.652000													10	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179605677	179605677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179605677C>T	ENST00000589042.1	-	48	12507	c.12283G>A	c.(12283-12285)Gag>Aag	p.E4095K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E3732K|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E3924K|TTN_ENST00000359218.5_Missense_Mutation_p.E3857K|TTN_ENST00000591111.1_Missense_Mutation_p.E3778K|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3778							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAATATGCTCATAAGATAGT	0.408000													35	76					0	0	1	0	0
CNTN2	6900	broad.mit.edu	37	1	205038639	205038639	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205038639G>A	ENST00000331830.4	+	17	2430	c.2146G>A	c.(2146-2148)Gga>Aga	p.G716R		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	716	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGCACCCTCAGGACTCAGCGG	0.597000													10	31					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54586243	54586243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54586243G>A	ENST00000545554.1	+	10	3969	c.3969G>A	c.(3967-3969)atG>atA	p.M1323I	UNC13C_ENST00000537900.1_Missense_Mutation_p.M1321I|UNC13C_ENST00000260323.11_Missense_Mutation_p.M1323I			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1323					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTGGAGAAATGGATGTCTGGT	0.343000													19	228					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169523	207169523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207169523G>A	ENST00000374423.3	+	5	657	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	91	Poly-Glu.						nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TGAAGAAGAGGAAGAGGATGA	0.438000													9	41					0	0	1	0	0
CEACAM1	634	broad.mit.edu	37	19	43023314	43023314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43023314C>T	ENST00000161559.6	-	5	1166	c.1032G>A	c.(1030-1032)gtG>gtA	p.V344V	CEACAM1_ENST00000352591.5_Intron|LIPE-AS1_ENST00000457234.2_RNA|CEACAM1_ENST00000599389.1_Intron|LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA|CEACAM1_ENST00000351134.3_Intron|CEACAM1_ENST00000403444.3_Silent_p.V344V|CEACAM1_ENST00000403461.1_Intron|CEACAM1_ENST00000358394.3_Intron|CEACAM1_ENST00000308072.4_Intron	NM_001712.4	NP_001703.2	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	344	Ig-like C2-type 3.				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	17		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	AGGTCAGGTTCACAGAGTCCT	0.502000													56	98					0	0	1	0	0
FBLN5	10516	broad.mit.edu	37	14	92347740	92347740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92347740C>T	ENST00000267620.10	-	10	1177	c.1008G>A	c.(1006-1008)agG>agA	p.R336R	FBLN5_ENST00000556154.1_Silent_p.R300R|FBLN5_ENST00000342058.4_Silent_p.R295R			Q9UBX5	FBLN5_HUMAN	fibulin 5	295					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				ACGTGTGGTTCCTGTGCTCAC	0.557000													29	72					0	0	1	0	0
HTR1F	3355	broad.mit.edu	37	3	88039932	88039932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:88039932G>A	ENST00000319595.4	+	1	87	c.33G>A	c.(31-33)ttG>ttA	p.L11L		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	11					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity	p.L11L(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	ATCAAAACTTGACCTCAGAGG	0.373000													36	120					0	0	1	0	0
ZNF175	7728	broad.mit.edu	37	19	52091439	52091439	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52091439A>G	ENST00000262259.2	+	5	2213	c.1855A>G	c.(1855-1857)Aaa>Gaa	p.K619E	ZNF175_ENST00000436511.2_Intron	NM_007147.2	NP_009078.1	Q9Y473	ZN175_HUMAN	zinc finger protein 175	619					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		TGTCTGTTACAAATGTGGGAA	0.433000													69	145					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9014636	9014636	+	Missense_Mutation	SNP	G	G	A	rs34857031		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9014636G>A	ENST00000397910.4	-	31	38542	c.38339C>T	c.(38338-38340)cCt>cTt	p.P12780L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12782	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCCACTCCAGGGCTTTTGGG	0.562000													27	92					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22705588	22705588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:22705588G>A	ENST00000376603.2	+	11	1871	c.1729G>A	c.(1729-1731)Gtg>Atg	p.V577M	SPAG6_ENST00000376601.1_Missense_Mutation_p.V262M|SPAG6_ENST00000538630.1_Missense_Mutation_p.V476M|SPAG6_ENST00000376624.3_Missense_Mutation_p.V501M|SPAG6_ENST00000313311.6_Missense_Mutation_p.G452D			O75602	SPAG6_HUMAN	sperm associated antigen 6	501					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						TCTGCAGAGGGTGGACAGCTA	0.358000													39	107					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54964810	54964810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54964810C>T	ENST00000326764.5	+	5	880	c.401C>T	c.(400-402)cCc>cTc	p.P134L	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	105							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CCATCCGCACCCCAACACCAA	0.567000													19	67					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43416923	43416923	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43416923C>T	ENST00000244533.3	+	18	4459	c.4100C>T	c.(4099-4101)gCt>gTt	p.A1367V	ABCC10_ENST00000372530.4_Missense_Mutation_p.A1395V	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	1395	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TTGGCCAGGGCTCTCCTCACA	0.592000													8	63					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77386669	77386669	+	Missense_Mutation	SNP	C	C	T	rs139669465	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77386669C>T	ENST00000451710.3	-	25	3723	c.3486G>A	c.(3484-3486)atG>atA	p.M1162I	TRPM6_ENST00000376864.4_Missense_Mutation_p.M1162I|TRPM6_ENST00000449912.2_Missense_Mutation_p.M1157I|TRPM6_ENST00000360774.1_Missense_Mutation_p.M1162I|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.M1157I|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1162					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TCACATCTTCCATCTTCTCAT	0.363000													7	83					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16967672	16967672	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:16967672G>A	ENST00000377833.4	-	42	6438	c.6373C>T	c.(6373-6375)Caa>Taa	p.Q2125*		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2125	CUB 15.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGGCCACTTTGGACCAGGACG	0.502000													26	63					0	0	1	0	0
MYL7	58498	broad.mit.edu	37	7	44178607	44178607	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44178607G>A	ENST00000458240.1	-	6	648	c.360C>T	c.(358-360)ttC>ttT	p.F120F	MYL7_ENST00000223364.3_Silent_p.F147F|MYL7_ENST00000434895.1_5'UTR			Q01449	MLRA_HUMAN	myosin, light chain 7, regulatory	147	EF-hand 2.				actin filament-based movement|smooth muscle contraction	A band|myosin complex	ATPase activity, coupled|calcium ion binding|microfilament motor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	12						GTGTCAGGGCGAACATCTGCT	0.612000													17	42					0	0	1	0	0
POMC	5443	broad.mit.edu	37	2	25384054	25384054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:25384054C>T	ENST00000405623.1	-	3	1155	c.700G>A	c.(700-702)Gac>Aac	p.D234N	POMC_ENST00000264708.3_Missense_Mutation_p.D234N|POMC_ENST00000380794.1_Missense_Mutation_p.D234N|POMC_ENST00000395826.2_Missense_Mutation_p.D234N			P01189	COLI_HUMAN	proopiomelanocortin	234					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	TAGCGCTTGTCCTTGGGCGGG	0.637000													4	42					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196648906	196648906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196648906C>T	ENST00000367429.4	+	6	1013	c.773C>T	c.(772-774)cCg>cTg	p.P258L	CFH_ENST00000439155.2_Missense_Mutation_p.P258L|CFH_ENST00000359637.2_Missense_Mutation_p.P194L	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	258	Sushi 4.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GGATGGCGTCCGTTGCCTTCA	0.289000													5	54					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143054022	143054022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143054022C>T	ENST00000409408.1	-	6	2328	c.620G>A	c.(619-621)aGc>aAc	p.S207N	FAM131B_ENST00000443739.2_Missense_Mutation_p.S235N|FAM131B_ENST00000409578.1_Missense_Mutation_p.S223N|FAM131B_ENST00000409346.1_Missense_Mutation_p.S207N|FAM131B_ENST00000409222.3_Missense_Mutation_p.S207N			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	207										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					GGACTGATCGCTGGCTTCCCA	0.557000													14	56					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685415	248685415	+	Silent	SNP	C	C	T	rs146219175	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248685415C>T	ENST00000343414.4	+	1	500	c.468C>T	c.(466-468)tcC>tcT	p.S156S		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCATCACCTCCCTAATTCAGT	0.577000													11	38					0	0	1	0	0
BCL10	8915	broad.mit.edu	37	1	85733503	85733503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85733503G>A	ENST00000370580.1	-	3	1246	c.509C>T	c.(508-510)tCt>tTt	p.S170F		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	170					apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		ATTCAGAGAAGAATTAGTAGA	0.448000			T	IGH@	MALT								20	150					0	0	1	0	0
ANKLE1	126549	broad.mit.edu	37	19	17394122	17394122	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17394122C>T	ENST00000394458.3	+	5	825	c.549C>T	c.(547-549)ggC>ggT	p.G183G	ANKLE1_ENST00000594072.1_Silent_p.G172G|ANKLE1_ENST00000598347.1_Silent_p.G183G|ANKLE1_ENST00000404085.1_Silent_p.G205G|ANKLE1_ENST00000433424.2_Silent_p.G237G	NM_152363.4	NP_689576.4	Q8NAG6	ANKL1_HUMAN	ankyrin repeat and LEM domain containing 1	183						nuclear envelope				large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	7						GGGACATTGGCTTGGAGGCTG	0.602000													29	126					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7242035	7242035	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7242035G>A	ENST00000542285.1	-	5	768	c.619C>T	c.(619-621)Ctg>Ttg	p.L207L				P00736	C1R_HUMAN	complement component 1, r subcomponent	208	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GGGTACTCCAGGCTGGAGATG	0.632000													23	15					0	0	1	0	0
SSTR3	6753	broad.mit.edu	37	22	37602795	37602795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37602795C>T	ENST00000328544.3	-	2	1581	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K	SSTR3_ENST00000402501.1_Missense_Mutation_p.E350K	NM_001051.3	NP_001042.1	P32745	SSR3_HUMAN	somatostatin receptor 3	350	Glu-rich (acidic).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	14						tcatcctcctcctcAGTCTTC	0.687000													26	51					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038913	11038913	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11038913G>A	ENST00000470054.1	-	0	1290									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTTGGGGAGGAAGACACATC	0.423000													28	614					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160826660	160826660	+	Splice_Site	SNP	G	G	A	rs113304621	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160826660G>A	ENST00000283243.7	-	18	2865	c.2660_splice	c.e18+1	p.R887_splice	PLA2R1_ENST00000392771.1_Splice_Site_p.R887_splice	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	887	C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding	p.R887C(1)	PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GGTTCATACCGAAATTCATCA	0.318000													27	66					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178423749	178423749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:178423749C>T	ENST00000448150.3	+	12	2941	c.2123C>T	c.(2122-2124)tCc>tTc	p.S708F	RASAL2_ENST00000367649.3_Missense_Mutation_p.S726F|RASAL2_ENST00000462775.1_Missense_Mutation_p.S578F	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	578					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						GTTTTGCATTCCTTACTGTGG	0.413000													23	93					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123844591	123844591	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123844591C>T	ENST00000369005.1	+	4	2916	c.2576C>T	c.(2575-2577)tCt>tTt	p.S859F	TACC2_ENST00000334433.3_Missense_Mutation_p.S859F|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.S859F|TACC2_ENST00000515273.1_Missense_Mutation_p.S859F|TACC2_ENST00000453444.2_Missense_Mutation_p.S859F	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	859						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AAAGAGACTTCTCCAAGCCAT	0.512000													41	88					0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43495431	43495431	+	Missense_Mutation	SNP	C	C	T	rs150037117	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43495431C>T	ENST00000300215.3	-	11	2208	c.1751G>A	c.(1750-1752)cGa>cAa	p.R584Q	EPB42_ENST00000540029.1_Missense_Mutation_p.R476Q|EPB42_ENST00000563128.1_5'UTR|EPB42_ENST00000441366.2_Missense_Mutation_p.R554Q			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	554					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		GGGTGGGTTTCGCTCAAAATT	0.478000													24	79					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208798	140208798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140208798G>A	ENST00000529310.1	+	1	1236	c.1122G>A	c.(1120-1122)gtG>gtA	p.V374V	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Silent_p.V374V	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAATTAGCGTGAACGACCTCG	0.498000													60	160					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10089654	10089654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10089654C>T	ENST00000264828.3	-	40	2962	c.2877G>A	c.(2875-2877)ggG>ggA	p.G959G		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	959	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GTCCCAGTTCCCCCTACAGGA	0.622000													3	16					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740765	140740765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140740765C>T	ENST00000522605.1	+	1	1063	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTATCTACTCCCCTACCGGA	0.458000													21	60					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123301256	123301256	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123301256C>T	ENST00000296513.2	+	3	217	c.32C>T	c.(31-33)tCg>tTg	p.S11L	ADAD1_ENST00000388725.2_5'UTR|ADAD1_ENST00000388724.2_Missense_Mutation_p.S11L	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	11					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TTTCAGAGTTCGCAGGTCCCC	0.433000													16	43					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237167	56237167	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56237167C>T	ENST00000312240.2	-	1	847	c.807G>A	c.(805-807)ggG>ggA	p.G269G		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					CCACCATCTTCCCCTGCTCCA	0.463000													7	33					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36848065	36848065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36848065G>A	ENST00000279024.4	-	11	2794	c.2523C>T	c.(2521-2523)gtC>gtT	p.V841V		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	841										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GGCCCAGGCGGACACGGAGCT	0.622000													27	95					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21228550	21228550	+	Silent	SNP	G	G	A	rs75165693		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21228550G>A	ENST00000233242.1	-	26	11317	c.11190C>T	c.(11188-11190)ttC>ttT	p.F3730F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3730					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGGAATAATGAATTTATCAG	0.408000													54	157					0	0	1	0	0
HTR3D	200909	broad.mit.edu	37	3	183756736	183756736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183756736C>T	ENST00000382489.3	+	8	1338	c.1338C>T	c.(1336-1338)atC>atT	p.I446I	HTR3D_ENST00000428798.2_Silent_p.I396I|HTR3D_ENST00000334128.2_Silent_p.I271I|HTR3D_ENST00000453435.1_Silent_p.I225I	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	446						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCTCCATCATCACCGTCATAT	0.567000													32	126					0	0	1	0	0
MED26	9441	broad.mit.edu	37	19	16686990	16686990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16686990C>T	ENST00000263390.3	-	3	1913	c.1651G>A	c.(1651-1653)Gat>Aat	p.D551N	CTD-3222D19.2_ENST00000409035.1_Intron	NM_004831.3	NP_004822.2	O95402	MED26_HUMAN	mediator complex subunit 26	551					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	8						CTGTCGAGATCGTCCTGTGTG	0.642000													24	59					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53586454	53586454	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:53586454G>A	ENST00000025008.5	-	7	1476	c.953C>T	c.(952-954)cCt>cTt	p.P318L	RB1CC1_ENST00000435644.2_Missense_Mutation_p.P318L|RB1CC1_ENST00000539297.1_Missense_Mutation_p.P318L|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	318					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CACATCATTAGGTCTATCTTG	0.338000													14	55					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32740570	32740570	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32740570C>T	ENST00000373564.3	+	2	338	c.338C>T	c.(337-339)tCc>tTc	p.S113F	LCK_ENST00000336890.5_Intron|LCK_ENST00000333070.4_Intron			P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	0	SH3.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GCTCGGTTCTCCCTGATGCCC	0.582000			T	TRB@	T-ALL								27	72					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131412	72131412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:72131412C>T	ENST00000265381.4	-	2	937	c.715G>A	c.(715-717)Gac>Aac	p.D239N		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	239	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						GAGCGCTCGTCGTAATGGTGC	0.716000													11	17					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22170068	22170068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22170068C>T	ENST00000397126.4	-	3	324	c.176G>A	c.(175-177)gGa>gAa	p.G59E	ZNF208_ENST00000599916.1_Missense_Mutation_p.G59E|ZNF208_ENST00000597040.1_Missense_Mutation_p.G27E|ZNF208_ENST00000601773.1_Missense_Mutation_p.G59E	NM_007153.3	NP_009084.2			zinc finger protein 208									p.G59E(3)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGACTCTTTTCCTTCCTCCAG	0.413000													9	106					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36468525	36468525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36468525C>T	ENST00000405275.2	+	13	1397	c.1154C>T	c.(1153-1155)gCt>gTt	p.A385V	CTNNBL1_ENST00000373473.1_Missense_Mutation_p.A225V|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.A412V|CTNNBL1_ENST00000473857.1_3'UTR|CTNNBL1_ENST00000373469.1_Missense_Mutation_p.A160V			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	412					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				TCGATCCTGGCTTCCCTCCTG	0.493000													18	47					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76397896	76397896	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76397896C>T	ENST00000357063.3	+	16	4252	c.2992C>T	c.(2992-2994)Caa>Taa	p.Q998*	LMO7_ENST00000341547.4_Nonsense_Mutation_p.Q664*|LMO7_ENST00000377534.3_Nonsense_Mutation_p.Q998*|LMO7_ENST00000321797.8_Nonsense_Mutation_p.Q713*|LMO7_ENST00000465261.2_Nonsense_Mutation_p.Q713*|LMO7_ENST00000526202.1_Nonsense_Mutation_p.Q563*			Q8WWI1	LMO7_HUMAN	LIM domain 7	998						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding	p.Q713K(1)|p.Q664K(1)|p.Q998K(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		ATCTCTTTCCCAAGACCAGGC	0.478000													25	59					0	0	1	0	0
HAUS5	23354	broad.mit.edu	37	19	36110939	36110939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36110939C>T	ENST00000203166.5	+	16	1457	c.1432C>T	c.(1432-1434)Cca>Tca	p.P478S	HAUS5_ENST00000379045.2_3'UTR	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	478					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						CACGGTCCTCCCATCCATCCA	0.672000													86	215					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212295675	212295675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:212295675C>T	ENST00000342788.4	-	21	2948	c.2638G>A	c.(2638-2640)Gga>Aga	p.G880R	ERBB4_ENST00000436443.1_Missense_Mutation_p.G880R|ERBB4_ENST00000402597.1_Missense_Mutation_p.G870R	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	880	Protein kinase.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CCCACCTTTCCTCCATCAGCA	0.363000										TSP Lung(8;0.080)			48	115					0	0	1	0	0
SYTL4	94121	broad.mit.edu	37	X	99934391	99934391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:99934391C>T	ENST00000455616.1	-	16	1923	c.1577G>A	c.(1576-1578)gGa>gAa	p.G526E	SYTL4_ENST00000454200.2_Missense_Mutation_p.G528E|SYTL4_ENST00000276141.6_Missense_Mutation_p.G526E|SYTL4_ENST00000372989.1_Missense_Mutation_p.G526E|SYTL4_ENST00000263033.5_Missense_Mutation_p.G526E			Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	526	C2 2.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(2)	27					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGGAGCTCTCCCCCTTCCCC	0.512000													31	14					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46898811	46898811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:46898811C>T	ENST00000378623.1	-	23	3458	c.3216G>A	c.(3214-3216)gtG>gtA	p.V1072V		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1072					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		TTGGTACCACCACATCAGCAA	0.527000													20	69					0	0	1	0	0
SOHLH2	54937	broad.mit.edu	37	13	36788653	36788653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36788653G>A	ENST00000379881.3	-	1	99	c.11C>T	c.(10-12)tCa>tTa	p.S4L	SOHLH2_ENST00000317764.6_Missense_Mutation_p.S4L|CCDC169-SOHLH2_ENST00000511166.1_Intron|SOHLH2_ENST00000554962.1_Intron	NM_017826.2	NP_060296.2			spermatogenesis and oogenesis specific basic helix-loop-helix 2											autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		GCAGATAATTGAGGAAGCCAT	0.667000													11	19					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151751698	151751698	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151751698G>A	ENST00000368822.1	-	5	1075	c.442C>T	c.(442-444)Cgt>Tgt	p.R148C	TDRKH_ENST00000458431.2_Missense_Mutation_p.R148C|TDRKH_ENST00000368823.1_Missense_Mutation_p.R144C|TDRKH_ENST00000440583.2_5'UTR|TDRKH_ENST00000368824.3_Missense_Mutation_p.R148C|TDRKH_ENST00000484421.1_5'UTR|TDRKH_ENST00000368825.3_Intron|TDRKH_ENST00000368827.6_Missense_Mutation_p.R148C			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	148	KH 2.						RNA binding	p.R148C(1)		breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CAGATAGAACGAATTGTCTCG	0.398000													23	75					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7311894	7311894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7311894C>T	ENST00000302926.2	+	1	393	c.320C>T	c.(319-321)cCg>cTg	p.P107L	NLGN2_ENST00000575301.1_Missense_Mutation_p.P107L	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	107					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				CCCGCCTGCCCGCAGAACCTG	0.741000													3	2					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125513025	125513025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125513025G>A	ENST00000373684.1	+	1	1007	c.1007G>A	c.(1006-1008)aGg>aAg	p.R336K	OR1L6_ENST00000304720.2_Missense_Mutation_p.R300K			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	336					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R336T(1)		breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						GATATGAAGAGGGGTTTGAAG	0.408000													21	42					0	0	1	0	0
TMEM133	83935	broad.mit.edu	37	11	100863138	100863138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100863138C>T	ENST00000303130.2	+	1	328	c.99C>T	c.(97-99)ccC>ccT	p.P33P		NM_032021.2	NP_114410.1	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	33						integral to membrane				kidney(2)|large_intestine(1)|lung(1)|prostate(1)	5		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		TTACTTTCCCCTTGACTAAAG	0.428000													32	98					0	0	1	0	0
KRT77	374454	broad.mit.edu	37	12	53096708	53096708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53096708G>A	ENST00000341809.3	-	1	539	c.511C>T	c.(511-513)Ctc>Ttc	p.L171F	KRT77_ENST00000537195.1_5'UTR	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	171	Coil 1A.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						ttgttgttgagaaccataatc	0.512000													45	131					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733505	152733505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152733505C>T	ENST00000368773.1	+	2	1499	c.1441C>T	c.(1441-1443)Ctg>Ttg	p.L481L	KPRP_ENST00000606109.1_Silent_p.L481L	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	481	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAATTCCCCTGCCGGCGCC	0.662000													52	103					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080123	54080123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54080123G>A	ENST00000253144.9	+	7	1642	c.309G>A	c.(307-309)atG>atA	p.M103I	ZNF331_ENST00000449416.1_Missense_Mutation_p.M103I|ZNF331_ENST00000513999.1_Missense_Mutation_p.M103I|ZNF331_ENST00000411977.2_Missense_Mutation_p.M103I|ZNF331_ENST00000512387.1_Missense_Mutation_p.M103I|ZNF331_ENST00000511154.1_Missense_Mutation_p.M103I|ZNF331_ENST00000513265.1_Intron|ZNF331_ENST00000511593.2_Missense_Mutation_p.M103I	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		TCAATCAGATGATCATCAATT	0.438000			T	?	follicular thyroid adenoma								25	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585180	179585180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179585180C>T	ENST00000589042.1	-	80	23533	c.23309G>A	c.(23308-23310)gGg>gAg	p.G7770E	TTN_ENST00000342992.6_Missense_Mutation_p.G6526E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G7453E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7453	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGATATTCCCCGACATCGGA	0.378000													38	105					0	0	1	0	0
PABPC1L	80336	broad.mit.edu	37	20	43541387	43541387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43541387C>T	ENST00000255136.3	+	2	362	c.280C>T	c.(280-282)Cgc>Tgc	p.R94C	PABPC1L_ENST00000537323.1_Missense_Mutation_p.R94C|PABPC1L_ENST00000217074.4_Missense_Mutation_p.R94C|PABPC1L_ENST00000217073.2_Missense_Mutation_p.R94C	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like	94							nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						CCCAGGACTTCGCAAGTCAGG	0.512000													16	77					0	0	1	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50474954	50474954	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50474954C>T	ENST00000602139.1	+	0	1029									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						GTGATGGTTTCCCAAGCAAAC	0.597000													30	97					0	0	1	0	0
HRH3	11255	broad.mit.edu	37	20	60791572	60791572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60791572C>T	ENST00000340177.5	-	3	1112	c.828G>A	c.(826-828)ggG>ggA	p.G276G	HRH3_ENST00000317393.6_Silent_p.G276G	NM_007232.2	NP_009163.2	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	276					G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity			breast(1)|endometrium(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	9	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	CCTCACCCACCCCATACCTGT	0.756000													5	7					0	0	1	0	0
RASSF6	166824	broad.mit.edu	37	4	74477528	74477528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74477528G>A	ENST00000342081.3	-	2	211	c.81C>T	c.(79-81)ctC>ctT	p.L27L	RASSF6_ENST00000395777.2_5'UTR|RASSF6_ENST00000307439.5_5'UTR|RASSF6_ENST00000335049.5_Intron|RASSF6_ENST00000512591.1_5'UTR	NM_201431.2	NP_958834.1	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family member 6	27					apoptosis|signal transduction		protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|pancreas(2)|skin(2)	17	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CCTCCTTTTTGAGATGGTCTG	0.333000													45	103					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794788	140794788	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140794788C>T	ENST00000398610.2	+	1	2046	c.2046C>T	c.(2044-2046)ttC>ttT	p.F682F	PCDHGA9_ENST00000573521.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGCAGCTTCGAGTCTCCAG	0.657000													57	137					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57425845	57425845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57425845C>T	ENST00000371237.4	-	2	163	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	C8B_ENST00000535057.1_5'UTR|C8B_ENST00000494324.1_5'UTR|C8B_ENST00000543257.1_5'UTR	NM_000066.2	NP_000057.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	33					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGTGGCCTTTCACCTCTAAAA	0.393000													26	76					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17157559	17157559	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17157559C>T	ENST00000180173.5	-	14	1829	c.1795G>A	c.(1795-1797)Gaa>Aaa	p.E599K	MTMR7_ENST00000398099.3_Missense_Mutation_p.E190K|VPS37A_ENST00000521162.1_3'UTR	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	599							protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		GCAGAATCTTCATCGCCTTGT	0.483000													9	125					0	0	1	0	0
VWC2	375567	broad.mit.edu	37	7	49951682	49951682	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:49951682G>A	ENST00000340652.3	+	4	1435	c.879G>A	c.(877-879)aaG>aaA	p.K293K	ZPBP_ENST00000491129.1_Intron	NM_198570.3	NP_940972.2	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	293					negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space				cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8						GAGAAGTGAAGACTGACGAGT	0.453000													18	65					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17071818	17071818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17071818C>T	ENST00000359963.3	-	1	1882	c.1623G>A	c.(1621-1623)aaG>aaA	p.K541K		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	541					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GTGGGTGTTTCTTTGTCTTCT	0.443000													36	145					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35043180	35043180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35043180G>A	ENST00000312292.5	+	2	601	c.554G>A	c.(553-555)gGg>gAg	p.G185E	C9orf131_ENST00000421362.2_Missense_Mutation_p.G137E|C9orf131_ENST00000354479.5_Missense_Mutation_p.G112E	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	185										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			ATAGCATCAGGGAACCGCCAG	0.567000													39	99					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220501453	220501453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220501453C>T	ENST00000358055.3	+	16	2904	c.2392C>T	c.(2392-2394)Ctc>Ttc	p.L798F	SLC4A3_ENST00000273063.6_Missense_Mutation_p.L825F|SLC4A3_ENST00000373760.2_Missense_Mutation_p.L798F|SLC4A3_ENST00000373762.3_Missense_Mutation_p.L825F|SLC4A3_ENST00000317151.3_Missense_Mutation_p.L798F			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	798	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGGGTTGGTCTCTGGCTGGT	0.622000													38	87					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102469297	102469297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102469297C>T	ENST00000360184.4	+	23	5042	c.4878C>T	c.(4876-4878)ttC>ttT	p.F1626F		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	1626	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GGTCATCTTTCCCCAGGTAAG	0.463000													22	48					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228153893	228153893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228153893G>A	ENST00000396578.3	+	35	3071	c.2909G>A	c.(2908-2910)gGa>gAa	p.G970E	AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	970	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGTGAGAAAGGAAACAGAGGC	0.483000													11	35					0	0	1	0	0
SULT1A2	6799	broad.mit.edu	37	16	28603583	28603583	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28603583C>T	ENST00000533150.1	-	3	1793		c.e3+1		SULT1A2_ENST00000335715.4_Splice_Site|SULT1A2_ENST00000395630.1_Splice_Site			P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2						3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|skin(2)	14						CCGGCACCTACCTTTCCTCAT	0.607000													24	111					0	0	1	0	0
BPIFB4	149954	broad.mit.edu	37	20	31682918	31682918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31682918C>T	ENST00000375483.3	+	10	1357	c.1357C>T	c.(1357-1359)Cct>Tct	p.P453S		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	453						cytoplasm|extracellular region	lipid binding										TGAAGAGCTTCCTCCACTTAC	0.488000													60	143					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48849077	48849077	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:48849077G>A	ENST00000314191.2	-	12	1170	c.1113_splice	c.e12-1	p.P372_splice	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Splice_Site_p.P372_splice	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	372					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACCTTGCACGGCTTTAGAAAA	0.378000								Non-homologous end-joining					18	38					0	0	1	0	0
FAM181A	90050	broad.mit.edu	37	14	94394743	94394743	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94394743C>T	ENST00000267594.5	+	3	605	c.298C>T	c.(298-300)Cgc>Tgc	p.R100C	FAM181A_ENST00000557719.1_Missense_Mutation_p.R38C|FAM181A_ENST00000557000.2_Missense_Mutation_p.R38C|FAM181A_ENST00000556222.1_Missense_Mutation_p.R38C	NM_001207073.1|NM_001207074.1|NM_138344.4	NP_001194002.1|NP_001194003.1|NP_612353.3	Q8N9Y4	F181A_HUMAN	family with sequence similarity 181, member A	100										cervix(1)|endometrium(2)|large_intestine(8)|lung(4)|prostate(1)|skin(2)	18						CGTGGACCATCGCAAGTACCT	0.612000													13	25					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55522958	55522958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:55522958C>T	ENST00000436346.1	-	31	6167	c.5326G>A	c.(5326-5328)Ggc>Agc	p.G1776S	CCDC88A_ENST00000413716.2_Intron|CCDC88A_ENST00000336838.6_Missense_Mutation_p.G1775S|CCDC88A_ENST00000263630.8_Missense_Mutation_p.G1748S|CCDC88A_ENST00000422883.2_Missense_Mutation_p.G277S	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1776					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						CCTTGAGTGCCTGGTGTAGGT	0.403000													23	65					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18770762	18770762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18770762C>T	ENST00000380548.4	+	17	2719	c.2380C>T	c.(2380-2382)Ctc>Ttc	p.L794F		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	794	TSP type-1 7.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CGAGTGGCTTCTCTCAGACTG	0.483000													14	17					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7812358	7812358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7812358G>A	ENST00000315599.7	-	1	62	c.40C>T	c.(40-42)Ctc>Ttc	p.L14F	CD209_ENST00000593660.1_5'UTR|CD209_ENST00000602261.1_Missense_Mutation_p.L14F|CD209_ENST00000601951.1_5'UTR|CD209_ENST00000394161.5_Missense_Mutation_p.L14F|CD209_ENST00000593821.1_Missense_Mutation_p.L14F|CD209_ENST00000204801.8_Missense_Mutation_p.L14F|CD209_ENST00000601256.1_5'UTR|CD209_ENST00000315591.8_Missense_Mutation_p.L14F|CD209_ENST00000394173.4_Missense_Mutation_p.L14F|CD209_ENST00000301357.8_Missense_Mutation_p.L14F|CD209_ENST00000354397.6_Missense_Mutation_p.L14F	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	14					cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TCACCCAGGAGGCCCAGCTGC	0.612000													96	221					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170118	58170118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58170118G>A	ENST00000309403.2	-	1	764	c.765C>T	c.(763-765)ttC>ttT	p.F255F		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GTAAGTACATGAAGATAATAG	0.463000													18	81					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95941690	95941690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95941690G>A	ENST00000317620.9	+	3	440	c.307G>A	c.(307-309)Gag>Aag	p.E103K	PROM2_ENST00000317668.4_Missense_Mutation_p.E103K|PROM2_ENST00000463580.1_Intron|PROM2_ENST00000542147.1_Missense_Mutation_p.E103K|PROM2_ENST00000403131.2_Missense_Mutation_p.E103K	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	103						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						GGTGCGGTACGAGGCGGGCTA	0.687000													4	12					0	0	1	0	0
LVRN	206338	broad.mit.edu	37	5	115348125	115348125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:115348125C>T	ENST00000357872.4	+	15	2426	c.2302C>T	c.(2302-2304)Cgt>Tgt	p.R768C		NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		768					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										AACTATAATTCGTGAAAATGT	0.289000													39	134					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172025193	172025193	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172025193G>A	ENST00000336824.4	+	10	1201	c.1102G>A	c.(1102-1104)Gag>Aag	p.E368K	FNDC3B_ENST00000415807.2_Missense_Mutation_p.E368K|FNDC3B_ENST00000416957.1_Missense_Mutation_p.E368K	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	368	Fibronectin type-III 1.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		ATCCTGCTCCGAGCCTGTTAG	0.502000													30	89					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67815433	67815433	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67815433C>T	ENST00000265686.3	+	13	1656	c.1548C>T	c.(1546-1548)atC>atT	p.I516I	TCIRG1_ENST00000532635.1_Silent_p.I300I	NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	516					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity	p.I516I(1)		breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						CCTTTGGCATCGATCCTGTGA	0.647000													16	34					0	0	1	0	0
C1QTNF6	114904	broad.mit.edu	37	22	37578762	37578762	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37578762G>A	ENST00000337843.2	-	3	378	c.303C>T	c.(301-303)gaC>gaT	p.D101D	C1QTNF6_ENST00000255836.6_Intron|C1QTNF6_ENST00000397110.2_Silent_p.D101D|C1QTNF6_ENST00000470655.1_Intron|RP1-151B14.6_ENST00000419128.1_RNA	NM_031910.3	NP_114116.3	Q9BXI9	C1QT6_HUMAN	C1q and tumor necrosis factor related protein 6	82	Collagen-like.					collagen				breast(1)|large_intestine(2)|lung(6)|stomach(1)|upper_aerodigestive_tract(1)	11						TTGGGCCTGGGTCCCCTTTGT	0.642000													14	20					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172163094	172163094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172163094G>A	ENST00000241256.2	-	2	1000	c.958C>T	c.(958-960)Ccc>Tcc	p.P320S		NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	320					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TACAGAATGGGGTTGATGGCA	0.502000													35	103					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14859437	14859437	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14859437G>A	ENST00000380881.4	-	5	1190	c.375C>T	c.(373-375)gtC>gtT	p.V125V	FREM1_ENST00000422223.2_Silent_p.V125V|FREM1_ENST00000380880.3_Silent_p.V125V			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	125					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCAGGAGATAGACCCACAGGA	0.403000													60	107					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72360523	72360523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72360523C>T	ENST00000441259.1	-	2	296	c.136G>A	c.(136-138)Gag>Aag	p.E46K	PRF1_ENST00000373209.2_Missense_Mutation_p.E46K	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	46	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						TCCACACCCTCCCCGGCCAGC	0.682000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				6	46					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107845226	107845226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:107845226G>A	ENST00000285311.3	-	4	1370	c.665C>T	c.(664-666)tCt>tTt	p.S222F	DKK2_ENST00000513208.1_Missense_Mutation_p.S122F|DKK2_ENST00000510463.1_Missense_Mutation_p.S176F	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	222	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space		p.S222F(1)|p.S222Y(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CAGCCCATGAGAACCCTTCTT	0.502000													45	128					0	0	1	0	0
CYP2F1	1572	broad.mit.edu	37	19	41628036	41628036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41628036G>A	ENST00000331105.2	+	6	892	c.820G>A	c.(820-822)Gag>Aag	p.E274K		NM_000774.3	NP_000765.2	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F, polypeptide 1	274					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(11)|ovary(2)|skin(2)	29						CAAGATGGCAGAGGTAATCCC	0.602000													12	27					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169586315	169586315	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169586315C>T	ENST00000263686.6	-	3	469	c.432G>A	c.(430-432)aaG>aaA	p.K144K	SELP_ENST00000367792.2_Silent_p.K144K|SELP_ENST00000458599.2_Silent_p.K144K|SELP_ENST00000367791.2_Silent_p.K144K|SELP_ENST00000367788.2_Silent_p.K144K|SELP_ENST00000367786.2_Silent_p.K144K|SELP_ENST00000367794.2_Silent_p.K144K|SELP_ENST00000367793.2_Silent_p.K144K	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	144	C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CATCATTCCACTTGCCAGGGG	0.453000													49	145					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150931954	150931954	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:150931954G>A	ENST00000309170.3	-	3	463	c.151C>T	c.(151-153)Ccc>Tcc	p.P51S	P2RY14_ENST00000424796.2_Missense_Mutation_p.P51S|MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	51						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTAGAGCTGGGCACGTAAAAG	0.438000													30	96					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33143334	33143334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:33143334C>T	ENST00000375030.2	+	22	2252	c.1634C>T	c.(1633-1635)tCg>tTg	p.S545L	C10orf68_ENST00000375028.3_Missense_Mutation_p.S590L|C10orf68_ENST00000375025.4_Missense_Mutation_p.S650L			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	586										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						TTAGGGCATTCGAAAGTTGTT	0.279000													13	38					0	0	1	0	0
DSCR4	10281	broad.mit.edu	37	21	39427006	39427006	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39427006G>A	ENST00000328264.3	-	3	404	c.300C>T	c.(298-300)ctC>ctT	p.L100L	DSCR4_ENST00000398948.1_Intron	NM_005867.2	NP_005858.1	P56555	DSCR4_HUMAN	Down syndrome critical region gene 4	100										large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	6						ATTTCTTGTGGAGCCCATGGA	0.463000													36	88					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372625	126372625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126372625C>T	ENST00000394329.3	+	9	10467	c.10454C>T	c.(10453-10455)tCa>tTa	p.S3485L	FAT4_ENST00000335110.5_Missense_Mutation_p.S1783L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3485	Cadherin 33.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCTGTTGATTCAGGGACCCCC	0.458000													59	146					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981621	70981621	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70981621G>A	ENST00000276594.2	-	2	676	c.475C>T	c.(475-477)Ctg>Ttg	p.L159L		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TCAGGTAACAGAGAAGCATCC	0.562000													8	52					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71978050	71978050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71978050G>A	ENST00000266674.5	+	18	2571	c.2260G>A	c.(2260-2262)Gga>Aga	p.G754R	LGR5_ENST00000536515.1_Missense_Mutation_p.G682R|LGR5_ENST00000540815.2_Missense_Mutation_p.G730R			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	754						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TTTGGACAAGGGAGACCTGGA	0.483000													19	129					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382697	22382697	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22382697C>T	ENST00000328795.4	+	1	316	c.225C>T	c.(223-225)ttC>ttT	p.F75F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCTACTCCTTCATTGTGGCTC	0.478000													56	233					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35648033	35648033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:35648033C>T	ENST00000287272.2	+	16	2627	c.2607C>T	c.(2605-2607)tcC>tcT	p.S869S	UNC5D_ENST00000416672.1_Silent_p.S943S|UNC5D_ENST00000420357.1_Silent_p.S871S|UNC5D_ENST00000449677.1_Silent_p.S514S|UNC5D_ENST00000404895.2_Silent_p.S938S|UNC5D_ENST00000453357.2_Silent_p.S933S			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	938	Death.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTTCAGAATCCCAGCTTGATG	0.502000													20	50					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90052277	90052277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90052277C>T	ENST00000405460.2	+	56	11683	c.11587C>T	c.(11587-11589)Ctt>Ttt	p.L3863F		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3863	Calx-beta 25.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCAGGATGACCTTCCTGAATT	0.408000													44	109					0	0	1	0	0
PAGE4	9506	broad.mit.edu	37	X	49597218	49597218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:49597218C>T	ENST00000218068.6	+	4	336	c.257C>T	c.(256-258)cCa>cTa	p.P86L	PAGE4_ENST00000376141.1_Missense_Mutation_p.P86L	NM_007003.2	NP_008934.1	O60829	GAGC1_HUMAN	P antigen family, member 4 (prostate associated)	86												Ovarian(276;0.236)					GAGAAGACTCCACCTAATCCT	0.383000													20	30					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47228830	47228830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47228830G>A	ENST00000391910.3	-	10	1795	c.1345C>T	c.(1345-1347)Cgt>Tgt	p.R449C	STRN4_ENST00000539396.1_Missense_Mutation_p.R323C|STRN4_ENST00000263280.6_Missense_Mutation_p.R442C|STRN4_ENST00000594357.2_5'UTR			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	442						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding	p.R442C(1)		NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GCCAGGGAACGAATGCCGTCG	0.612000													13	44					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332927	70332927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70332927G>A	ENST00000338508.4	-	32	3473	c.3474C>T	c.(3472-3474)ttC>ttT	p.F1158F	SHANK2_ENST00000449833.2_Silent_p.F562F|SHANK2_ENST00000423696.2_Silent_p.F778F|SHANK2_ENST00000409161.1_Silent_p.F561F			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	778					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding	p.F1158F(1)|p.F562F(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CGCCACCCACGAAATGGTTTT	0.672000													29	69					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104067702	104067702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104067702G>A	ENST00000388887.2	+	23	2593	c.2389G>A	c.(2389-2391)Gga>Aga	p.G797R		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	797					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTGCGTTCACGGAACATGCAA	0.592000													12	47					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5058617	5058617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:5058617C>T	ENST00000251170.7	+	14	1948	c.1768C>T	c.(1768-1770)Ccc>Tcc	p.P590S		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	590	GOLD.					integral to membrane|intracellular	transporter activity	p.P590A(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						TGTGGAGGCTCCCCTTGTCTG	0.657000													26	70					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	76955545	76955545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76955545C>T	ENST00000257626.7	-	23	1889	c.1811G>A	c.(1810-1812)cGg>cAg	p.R604Q	GSAP_ENST00000441833.2_5'UTR|GSAP_ENST00000440473.1_5'UTR	NM_017439.3	NP_059135.2			gamma-secretase activating protein																		CATGAGCAGCCGCTGGTGGCT	0.512000													23	69					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039138	11039138	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039138G>A	ENST00000470054.1	-	0	1065									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGGACATAATGAAGTGCTTTC	0.403000													48	550					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45281402	45281402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45281402G>A	ENST00000270279.3	+	1	277	c.214G>A	c.(214-216)Ggt>Agt	p.G72S	CBLC_ENST00000341505.4_Missense_Mutation_p.G72S	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	72	4H.|Cbl-PTB.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				cggccccgggggtcccggcgg	0.726000			M		AML								8	6					0	0	1	0	0
RASEF	158158	broad.mit.edu	37	9	85622405	85622405	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:85622405G>A	ENST00000376447.3	-	7	1235	c.975C>T	c.(973-975)atC>atT	p.I325I		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	325					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TGTATGCTCGGATTATTTCCA	0.398000													47	69					0	0	1	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74364582	74364582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74364582C>T	ENST00000290438.3	-	14	1610	c.1570G>A	c.(1570-1572)Gac>Aac	p.D524N		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	524										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						CTCTCCAGGTCCTCTGGGATG	0.627000													10	176					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65239505	65239505	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65239505G>A	ENST00000389722.3	-	25	5399	c.5346C>T	c.(5344-5346)ctC>ctT	p.L1782L	SPTB_ENST00000389720.3_Silent_p.L1782L|SPTB_ENST00000389721.5_Silent_p.L1782L|SPTB_ENST00000556626.1_Silent_p.L1782L|SPTB_ENST00000542895.1_Silent_p.L1782L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1782					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGAGCTCCAGGAGGTCTGCCC	0.627000													26	39					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231233	21231233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21231233C>T	ENST00000233242.1	-	26	8634	c.8507G>A	c.(8506-8508)aGa>aAa	p.R2836K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2836					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGCTCCGTTCTCAGGTACTT	0.408000													54	163					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6442295	6442295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6442295G>A	ENST00000162749.2	-	5	790	c.491C>T	c.(490-492)aCc>aTc	p.T164I	TNFRSF1A_ENST00000540022.1_Missense_Mutation_p.T121I|TNFRSF1A_ENST00000366159.4_Missense_Mutation_p.T164I|TNFRSF1A_ENST00000437813.3_5'UTR	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	164					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						GGTGCACACGGTGTTCTGTTT	0.557000													9	32					0	0	1	0	0
IGHV1-18	28468	broad.mit.edu	37	14	106641605	106641605	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106641605C>T	ENST00000390605.2	-	0	367																											ATCTCAGGCTCCTCAGCTCCA	0.537000													120	228					0	0	1	0	0
ASB17	127247	broad.mit.edu	37	1	76397716	76397716	+	Silent	SNP	G	G	A	rs11811988		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:76397716G>A	ENST00000284142.6	-	1	400	c.261C>T	c.(259-261)ctC>ctT	p.L87L		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	87					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						CAGTGAAGTCGAGGTTAAAAC	0.378000													7	68					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363937	22363937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22363937C>T	ENST00000397121.2	-	3	899	c.582G>A	c.(580-582)gaG>gaA	p.E194E		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TGTAGGGTTTCTCTCCAGTAT	0.348000													10	110					0	0	1	0	0
TXNRD1	7296	broad.mit.edu	37	12	104705146	104705146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104705146C>T	ENST00000526691.1	+	3	655	c.199C>T	c.(199-201)Ctt>Ttt	p.L67F	TXNRD1_ENST00000503506.2_Missense_Mutation_p.L15F|TXNRD1_ENST00000378070.4_Missense_Mutation_p.L114F|TXNRD1_ENST00000429002.2_Missense_Mutation_p.L165F|TXNRD1_ENST00000388854.3_Missense_Mutation_p.L67F|TXNRD1_ENST00000525566.1_Missense_Mutation_p.L165F|TXNRD1_ENST00000526390.1_Missense_Mutation_p.L59F|TXNRD1_ENST00000526950.1_Missense_Mutation_p.L84F|TXNRD1_ENST00000529546.1_Intron|TXNRD1_ENST00000540716.1_Intron|TXNRD1_ENST00000397736.2_Missense_Mutation_p.L59F|TXNRD1_ENST00000354940.6_Missense_Mutation_p.L15F|TXNRD1_ENST00000524698.1_Missense_Mutation_p.L15F|TXNRD1_ENST00000542918.1_Missense_Mutation_p.L65F|TXNRD1_ENST00000427956.1_Missense_Mutation_p.L130F	NM_001261445.1|NM_003330.3	NP_001248374.1|NP_003321.3	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	165	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						TGACTATGACCTTATCATCAT	0.443000													3	20					0	0	1	0	0
PLAUR	5329	broad.mit.edu	37	19	44171764	44171764	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44171764G>A	ENST00000221264.4	-	2	561	c.135C>T	c.(133-135)ctC>ctT	p.L45L	PLAUR_ENST00000601723.1_Silent_p.L45L|PLAUR_ENST00000339082.3_Silent_p.L45L|PLAUR_ENST00000340093.3_Silent_p.L45L	NM_001005377.2	NP_001005377.1	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	45	UPAR/Ly6 1.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(1)|stomach(1)|urinary_tract(3)	20		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	TGGTCCTGCAGAGGTCCTGTC	0.622000													20	50					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111239	7111239	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7111239G>A	ENST00000306904.5	+	1	1075	c.888G>A	c.(886-888)cgG>cgA	p.R296R		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	296	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCCCAGGACGGGGGACACCGC	0.662000													13	29					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38137471	38137471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:38137471C>T	ENST00000379747.4	-	23	2627	c.2510G>A	c.(2509-2511)tGa>tAa	p.*837*	POSTN_ENST00000379742.4_Silent_p.*780*|POSTN_ENST00000541179.1_Silent_p.*782*|POSTN_ENST00000379743.4_Silent_p.*810*|POSTN_ENST00000379749.4_Silent_p.*809*|POSTN_ENST00000541481.1_Silent_p.*750*	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	0					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TTTGGATTTTCACTGAGAACG	0.323000													21	41					0	0	1	0	0
VCX3B	425054	broad.mit.edu	37	X	8434313	8434313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:8434313G>A	ENST00000381032.1	+	3	937	c.630G>A	c.(628-630)atG>atA	p.M210I	VCX3B_ENST00000440654.2_Missense_Mutation_p.M160I|VCX3B_ENST00000381029.4_Missense_Mutation_p.M178I|VCX3B_ENST00000453306.1_Intron|VCX3B_ENST00000444481.1_Missense_Mutation_p.M180I	NM_001001888.3	NP_001001888.3	Q9H321	VCX3B_HUMAN	variable charge, X-linked 3B	210	11 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.					nucleolus				NS(1)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|urinary_tract(3)	11						AGAGCGAGATGGAAGAACCAC	0.562000													41	195					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156915384	156915384	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156915384C>T	ENST00000257527.4	-	21	2517	c.2439G>A	c.(2437-2439)agG>agA	p.R813R	ADAM19_ENST00000394020.1_Silent_p.R815R|ADAM19_ENST00000430702.2_Silent_p.R546R|ADAM19_ENST00000517905.1_Silent_p.R813R	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	813					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCCTAGCAGCCCTGCTCAGGT	0.652000													35	79					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189875434	189875434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189875434C>T	ENST00000304636.3	+	50	4242	c.4072C>T	c.(4072-4074)Cga>Tga	p.R1358*	COL3A1_ENST00000317840.5_Nonsense_Mutation_p.R1055*	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1358	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGCATTCCTTCGACTTCTCTC	0.428000													26	115					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974693	49974693	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:49974693C>T	ENST00000555099.1	+	1	751	c.719C>T	c.(718-720)tCc>tTc	p.S240F		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						ACCTGTGTCTCCCACATCACA	0.458000													59	85					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100148243	100148243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:100148243G>A	ENST00000370575.4	-	13	1363	c.1315C>T	c.(1315-1317)Cct>Tct	p.P439S	PYROXD2_ENST00000483923.1_Intron	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	439							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						AGCGAGGAAGGGATGCAGAGC	0.622000													8	13					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32371624	32371624	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32371624C>T	ENST00000375200.1	+	12	2171	c.1806C>T	c.(1804-1806)ttC>ttT	p.F602F	ZNF341_ENST00000342427.2_Silent_p.F595F			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	602					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GCAAGAAGTTCTTCCGGCGGG	0.617000													12	65					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43039079	43039079	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43039079C>T	ENST00000394056.2	+	10	1717	c.1222C>T	c.(1222-1224)Cgt>Tgt	p.R408C	KLC4_ENST00000453940.2_Missense_Mutation_p.R331C|KLC4_ENST00000394058.1_Missense_Mutation_p.R408C|KLC4_ENST00000347162.5_Missense_Mutation_p.R408C|KLC4_ENST00000259708.3_Missense_Mutation_p.R426C|KLC4_ENST00000479388.1_Missense_Mutation_p.R408C			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	408						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			GATCCTGACCCGTGCCCATGT	0.512000													16	43					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169141144	169141144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169141144G>A	ENST00000256935.8	+	18	1852	c.1772G>A	c.(1771-1773)gGg>gAg	p.G591E	DOCK2_ENST00000520908.1_Missense_Mutation_p.G83E|DOCK2_ENST00000540750.1_5'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	591	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTGTTGGGGGGCTTTCTGTC	0.542000													22	49					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49165917	49165917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49165917G>A	ENST00000418109.1	-	16	2156	c.1992C>T	c.(1990-1992)atC>atT	p.I664I	LAMB2_ENST00000305544.4_Silent_p.I664I	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	664	Laminin IV type B.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAGTCCCTTGGATGCGATCAT	0.612000													10	36					0	0	1	0	0
RNF182	221687	broad.mit.edu	37	6	13977612	13977612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13977612C>T	ENST00000488300.1	+	3	785	c.262C>T	c.(262-264)Ctt>Ttt	p.L88F	RNF182_ENST00000537663.1_Missense_Mutation_p.L88F|RNF182_ENST00000537388.1_Missense_Mutation_p.L88F|RNF182_ENST00000544682.1_Missense_Mutation_p.L88F	NM_152737.3	NP_689950.1	Q8N6D2	RN182_HUMAN	ring finger protein 182	88						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|large_intestine(7)|liver(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			CAACAACATCCTTGTAAACTT	0.542000													36	89					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128642808	128642808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128642808G>A	ENST00000344954.6	+	4	806	c.418G>A	c.(418-420)Gag>Aag	p.E140K	FLI1_ENST00000429175.2_Missense_Mutation_p.E173K|FLI1_ENST00000534087.1_Missense_Mutation_p.E140K|FLI1_ENST00000281428.8_Missense_Mutation_p.E107K|FLI1_ENST00000525560.1_Intron			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	173	PNT.				hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		AATGAACAAGGAGGACTTCCT	0.522000			T	EWSR1	Ewing sarcoma								47	141					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47601016	47601016	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:47601016G>A	ENST00000439988.2	-	5	618	c.619C>T	c.(619-621)Cga>Tga	p.R207*	MDGA2_ENST00000399232.2_Nonsense_Mutation_p.R276*|MDGA2_ENST00000426342.1_5'UTR|MDGA2_ENST00000357362.3_5'UTR			Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	207	Ig-like 2.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						TCCTGAGGTCGAAGATTCTTT	0.343000													19	44					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20559433	20559433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20559433C>T	ENST00000329697.6	-	8	1217	c.1049G>A	c.(1048-1050)aGg>aAg	p.R350K	ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565232.1_Missense_Mutation_p.R350K|ACSM2B_ENST00000565322.1_Missense_Mutation_p.R271K|ACSM2B_ENST00000567001.1_Missense_Mutation_p.R350K	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	350					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TGTCTGGGCCCTCCAGTTCTC	0.512000													45	205					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38357818	38357818	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38357818G>A	ENST00000273173.4	+	9	1627	c.1536G>A	c.(1534-1536)gcG>gcA	p.A512A	SLC22A14_ENST00000448498.1_Silent_p.A512A	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	512			A -> V (in dbSNP:rs2070492).			integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CTTTCAGGGCGACAGGTCTGG	0.612000													17	59					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26839553	26839553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:26839553G>A	ENST00000381340.3	-	11	1425	c.1009C>T	c.(1009-1011)Cct>Tct	p.P337S		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	337	MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GAAGTTGGAGGGACTCCATCT	0.398000													35	177					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184580816	184580816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184580816C>T	ENST00000287546.4	+	15	1527	c.1356C>T	c.(1354-1356)ttC>ttT	p.F452F	VPS8_ENST00000446204.2_Silent_p.F450F|VPS8_ENST00000437079.3_Silent_p.F452F|VPS8_ENST00000436792.2_Silent_p.F450F	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	452							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GCAGCCATTTCAAATCACTAG	0.408000													59	121					0	0	1	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315572	73315572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73315572G>A	ENST00000258098.6	-	3	1414	c.1174C>T	c.(1174-1176)Cgt>Tgt	p.R392C	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	392					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						CTGTTGCTACGACTGCCTCTG	0.637000													21	74					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53225270	53225270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53225270C>T	ENST00000330553.5	-	2	652	c.618G>A	c.(616-618)ctG>ctA	p.L206L		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	206	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GAAGTCTGTCCAGCGTGCTCC	0.612000													32	105					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2024083	2024083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2024083C>T	ENST00000568546.1	+	2	196	c.68C>T	c.(67-69)cCt>cTt	p.P23L		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	23					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						AAAATTGAGCCTTTCTACAAG	0.652000													8	34					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46930315	46930315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46930315C>T	ENST00000264318.3	-	9	2574	c.1592G>A	c.(1591-1593)gGg>gAg	p.G531E		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	531					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.G531V(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTTAAATGCCCCAAATGTGAC	0.388000													23	100					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99509613	99509613	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:99509613C>T	ENST00000261037.3	+	4	467	c.87C>T	c.(85-87)gcC>gcT	p.A29A	COL8A1_ENST00000273342.4_Silent_p.A29A	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	29	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						AGGCTGGTGCCTACTATGGGA	0.562000													26	42					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39226715	39226715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39226715G>A	ENST00000340369.3	-	2	4450	c.4222C>T	c.(4222-4224)Ccc>Tcc	p.P1408S	XIRP1_ENST00000421646.1_Missense_Mutation_p.P91S|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1408							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTGGGCCTGGGGGCCGTGGTG	0.602000													22	54					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61835772	61835772	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61835772G>A	ENST00000280772.1	-	37	5058	c.4867C>T	c.(4867-4869)Cga>Tga	p.R1623*	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1623	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGAGAGGTTCGAGAGGAAAAC	0.478000													30	89					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99944898	99944898	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:99944898G>A	ENST00000524871.1	+	13	1742	c.1452G>A	c.(1450-1452)ctG>ctA	p.L484L	CNTN5_ENST00000279463.3_Silent_p.L484L|CNTN5_ENST00000528682.1_Silent_p.L484L|CNTN5_ENST00000527185.1_Silent_p.L484L|CNTN5_ENST00000418526.2_Silent_p.L410L	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	484	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding	p.L484L(2)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTTTTGCACTGAATCAACTGA	0.373000													5	34					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157929367	157929367	+	Missense_Mutation	SNP	C	C	T	rs142423725		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157929367C>T	ENST00000389413.3	-	8	1256	c.1153G>A	c.(1153-1155)Gat>Aat	p.D385N	PTPRN2_ENST00000389416.4_Missense_Mutation_p.D368N|PTPRN2_ENST00000404321.2_Missense_Mutation_p.D408N|PTPRN2_ENST00000389418.4_Missense_Mutation_p.D385N|PTPRN2_ENST00000409483.1_Missense_Mutation_p.D347N	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	385						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGTCTATCATCGTCGTCCTGC	0.433000													10	100					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50532391	50532391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50532391C>T	ENST00000374144.3	+	3	2089	c.1801C>T	c.(1801-1803)Ccc>Tcc	p.P601S	C10orf71_ENST00000323868.4_Missense_Mutation_p.P601S			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	601										endometrium(1)	1						CGCCAAAGCCCCCTTCTATGT	0.547000													10	23					0	0	1	0	0
OSBPL6	114880	broad.mit.edu	37	2	179255882	179255882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179255882G>A	ENST00000190611.4	+	22	2760	c.2384G>A	c.(2383-2385)gGa>gAa	p.G795E	OSBPL6_ENST00000409045.3_Missense_Mutation_p.G764E|OSBPL6_ENST00000409631.1_Missense_Mutation_p.G759E|OSBPL6_ENST00000359685.3_Missense_Mutation_p.G759E|OSBPL6_ENST00000392505.2_Missense_Mutation_p.G820E|OSBPL6_ENST00000315022.2_Missense_Mutation_p.G799E	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	795					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CGGCTGTTTGGAAAGTGGCAT	0.527000													41	117					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10033879	10033879	+	Missense_Mutation	SNP	C	C	T	rs150596900		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:10033879C>T	ENST00000378380.3	+	8	2319	c.1990C>T	c.(1990-1992)Cct>Tct	p.P664S	SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000488991.1_3'UTR|ANKEF1_ENST00000378392.1_Missense_Mutation_p.P664S|SNAP25-AS1_ENST00000603542.1_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		AGGCAAGACACCTCCTATACT	0.348000													21	113					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51224954	51224954	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51224954G>A	ENST00000245441.5	-	18	2984	c.2794C>T	c.(2794-2796)Ctg>Ttg	p.L932L	NIN_ENST00000530997.2_Silent_p.L932L|NIN_ENST00000389868.3_Intron|NIN_ENST00000324330.9_Silent_p.L932L|NIN_ENST00000382041.3_Silent_p.L932L|NIN_ENST00000382043.4_Intron|NIN_ENST00000453196.1_Silent_p.L932L	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	932					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TCAGACAGCAGGCTTTGCTGG	0.517000			T	PDGFRB	MPD								49	124					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52812419	52812419	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52812419C>T	ENST00000273283.2	+	3	226	c.202C>T	c.(202-204)Cac>Tac	p.H68Y	ITIH1_ENST00000542827.1_Missense_Mutation_p.H68Y	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	68	VIT.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TCGCTTCGCCCACTATGTTGT	0.522000													48	98					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55525834	55525834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55525834C>T	ENST00000219070.4	+	8	1811	c.1302C>T	c.(1300-1302)tcC>tcT	p.S434S	MMP2_ENST00000437642.2_Silent_p.S384S|MMP2_ENST00000543485.1_Silent_p.S358S|MMP2_ENST00000570308.1_Silent_p.S358S	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	434	Collagenase-like 2.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	TCCGTCTGTCCCAGGATGACA	0.617000													13	31					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94935629	94935629	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94935629G>A	ENST00000337425.5	-	2	677	c.603C>T	c.(601-603)acC>acT	p.T201T	SERPINA9_ENST00000448305.2_Silent_p.T103T|SERPINA9_ENST00000424550.2_Silent_p.T52T|SERPINA9_ENST00000298845.7_Silent_p.T101T|SERPINA9_ENST00000546329.1_Silent_p.T165T|SERPINA9_ENST00000380365.3_Silent_p.T183T	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	183					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CCTTCCCTTGGGTCTTCTTTT	0.453000													58	174					0	0	1	0	0
FAM160B1	57700	broad.mit.edu	37	10	116605158	116605158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116605158C>T	ENST00000369248.4	+	8	1381	c.1046C>T	c.(1045-1047)tCa>tTa	p.S349L	FAM160B1_ENST00000369250.3_Missense_Mutation_p.S349L	NM_020940.3	NP_065991.3	Q5W0V3	F16B1_HUMAN	family with sequence similarity 160, member B1	349										NS(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)	25						GAAGATGCTTCAGCATTTCCA	0.358000													28	68					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46787167	46787167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46787167G>A	ENST00000262738.3	-	16	6165	c.6166C>T	c.(6166-6168)Ccc>Tcc	p.P2056S		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2056					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AATGCTTTGGGACAGCCATTG	0.617000											OREG0026656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	27					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178854323	178854323	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:178854323G>A	ENST00000367635.3	+	12	1355	c.1017G>A	c.(1015-1017)agG>agA	p.R339R	RALGPS2_ENST00000477383.1_3'UTR|RALGPS2_ENST00000367634.2_Silent_p.R339R|RALGPS2_ENST00000324778.4_Silent_p.R304R	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	339					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						ATGGACATAGGAAGTGCCATA	0.408000													12	70					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8651597	8651597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8651597C>T	ENST00000270328.4	-	19	2514	c.2248G>A	c.(2248-2250)Gga>Aga	p.G750R	ADAMTS10_ENST00000595838.1_Missense_Mutation_p.G237R|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.G750R			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	750	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TCCTGGTCTCCCTTCAGGGCT	0.637000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	87					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52258422	52258422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:52258422C>T	ENST00000356297.4	-	20	4087	c.3987G>A	c.(3985-3987)aaG>aaA	p.K1329K	PXDNL_ENST00000543296.1_Intron	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1329					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ACTCCATATCCTTATCAACAG	0.378000													14	51					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116858707	116858707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116858707C>T	ENST00000374118.3	-	5	521	c.284G>A	c.(283-285)cGa>cAa	p.R95Q	KIF12_ENST00000473174.1_5'UTR	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	228	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						GGCATGGCTTCGGCTGGAGGC	0.582000													6	11					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411707	23411707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23411707G>A	ENST00000379361.4	+	3	2932	c.2072G>A	c.(2071-2073)cGa>cAa	p.R691Q		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	691					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TACATGGATCGATATGCCTCC	0.488000													33	21					0	0	1	0	0
AADAC	13	broad.mit.edu	37	3	151545475	151545475	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151545475C>T	ENST00000232892.6	+	5	841	c.715C>T	c.(715-717)Cta>Tta	p.L239L	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	239					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TTCAAATTTTCTATTTCTATC	0.368000													34	71					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43230915	43230915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43230915G>A	ENST00000259750.4	+	13	1896	c.1813G>A	c.(1813-1815)Gag>Aag	p.E605K	TTBK1_ENST00000304139.5_Missense_Mutation_p.E554K	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	605						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGCGCTGGCGGAGGAGGACCT	0.756000													3	7					0	0	1	0	0
SLC25A41	284427	broad.mit.edu	37	19	6433541	6433541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6433541C>T	ENST00000321510.6	-	1	232	c.164G>A	c.(163-165)gGc>gAc	p.G55D		NM_173637.3	NP_775908.2	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	55					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	6						ATGCATGTGGCCAAACGCGTA	0.582000													23	74					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41181646	41181646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41181646C>T	ENST00000263413.3	-	7	1006	c.742G>A	c.(742-744)Gat>Aat	p.D248N	C6_ENST00000337836.5_Missense_Mutation_p.D248N|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	248	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding	p.D248Y(1)		central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTCAAGTCATCTTCTGCAGTT	0.348000													14	53					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21557827	21557827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:21557827G>A	ENST00000382592.4	-	5	2423	c.2018C>T	c.(2017-2019)aCc>aTc	p.T673I	LATS2_ENST00000542899.1_Missense_Mutation_p.T673I	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	673	Protein kinase.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		GATCCCCAGGGTTTTGATCTT	0.488000													45	110					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69327560	69327560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69327560G>A	ENST00000305363.4	+	2	97	c.33G>A	c.(31-33)agG>agA	p.R11R		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	11					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TGAGGGCTAGGAAAAGAGTTT	0.428000													143	347					0	0	1	0	0
ZNRF3	84133	broad.mit.edu	37	22	29446228	29446228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29446228C>T	ENST00000544604.2	+	8	2234	c.2059C>T	c.(2059-2061)Ctc>Ttc	p.L687F	ZNRF3_ENST00000332811.4_Missense_Mutation_p.L587F|ZNRF3_ENST00000402174.1_Missense_Mutation_p.L587F|ZNRF3_ENST00000406323.3_Missense_Mutation_p.L587F	NM_001206998.1	NP_001193927.1	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	687						integral to membrane	zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(4)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	28						AGAAGTGGGGCTCGAGGCTTC	0.667000													8	73					0	0	1	0	0
FCGR2B	2213	broad.mit.edu	37	1	161641278	161641278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161641278C>T	ENST00000367962.4	+	3	357	c.230C>T	c.(229-231)cCt>cTt	p.P77L	FCGR2B_ENST00000403078.3_Missense_Mutation_p.P77L|FCGR2B_ENST00000428605.2_Missense_Mutation_p.P77L|FCGR2B_ENST00000367961.4_Missense_Mutation_p.P70L|FCGR2B_ENST00000358671.5_Missense_Mutation_p.P77L|FCGR2B_ENST00000236937.9_Missense_Mutation_p.P77L|FCGR2B_ENST00000367960.5_Missense_Mutation_p.P70L			P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor (CD32)	77	Ig-like C2-type 1.				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity					all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACTCACAGCCCTGAGAGCGAC	0.582000			T	?	ALL								18	77					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31533829	31533829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31533829C>T	ENST00000215885.3	-	4	1185	c.933G>A	c.(931-933)ggG>ggA	p.G311G		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	311					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						GATGTGGTGGCCCCTTCCGAA	0.652000													61	139					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169394126	169394126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169394126C>T	ENST00000545005.1	-	3	547	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	CCDC181_ENST00000367806.3_Missense_Mutation_p.E14K|CCDC181_ENST00000367805.3_Missense_Mutation_p.E14K|CCDC181_ENST00000491570.1_5'UTR					coiled-coil domain containing 181																		TCTTCGTATTCTTCACTTTTC	0.308000													25	62					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773898	140773898	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140773898C>T	ENST00000398604.2	+	1	1518	c.1518C>T	c.(1516-1518)tcC>tcT	p.S506S	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTATATCTCCATCAACTCTG	0.592000													8	83					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160465879	160465879	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160465879C>T	ENST00000368059.3	-	2	423	c.354G>A	c.(352-354)aaG>aaA	p.K118K	SLAMF6_ENST00000368055.1_Intron|SLAMF6_ENST00000368057.3_Silent_p.K118K	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	118						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			AACTGGACAGCTTTGCAGAGG	0.423000													56	129					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634749	70634749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70634749C>T	ENST00000381269.2	-	2	1144	c.391G>A	c.(391-393)Gaa>Aaa	p.E131K	SLC8A3_ENST00000534137.1_Missense_Mutation_p.E131K|SLC8A3_ENST00000528359.1_Missense_Mutation_p.E131K|SLC8A3_ENST00000356921.2_Missense_Mutation_p.E131K|SLC8A3_ENST00000357887.3_Missense_Mutation_p.E131K	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	131					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GAGACAGTTTCATTCCAGACC	0.478000													29	44					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83636688	83636688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:83636688G>A	ENST00000265362.3	-	10	1435	c.1121C>T	c.(1120-1122)cCc>cTc	p.P374L	SEMA3A_ENST00000436949.1_Missense_Mutation_p.P374L	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	374	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CCGTGGATAGGGGACTCTTCC	0.423000													44	112					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51757907	51757907	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51757907G>A	ENST00000543196.2	-	5	1252	c.1047C>T	c.(1045-1047)atC>atT	p.I349I	GALNT6_ENST00000356317.3_Silent_p.I349I			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	349	Catalytic subdomain B.				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						GTCCTTACTTGATGGGGTAGG	0.552000													32	55					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55272965	55272965	+	Silent	SNP	C	C	T	rs143770509		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55272965C>T	ENST00000275493.2	+	28	3465	c.3288C>T	c.(3286-3288)tcC>tcT	p.S1096S	EGFR_ENST00000454757.2_Silent_p.S1043S|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	1096					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TAAACCAGTCCGTTCCCAAAA	0.527000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			11	43					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99640764	99640764	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:99640764C>T	ENST00000345514.2	-	3	2462	c.2196G>A	c.(2194-2196)aaG>aaA	p.K732K	BCL11B_ENST00000357195.3_Silent_p.K803K|BCL11B_ENST00000443726.2_Silent_p.K609K	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	803						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		TCTTGAACACCTTGCCGCAGT	0.711000			T	TLX3	T-ALL								4	19					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233393629	233393629	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233393629G>T	ENST00000258385.3	+	6	599	c.567G>T	c.(565-567)gaG>gaT	p.E189D	CHRND_ENST00000536614.1_Intron|CHRND_ENST00000543200.1_Missense_Mutation_p.E174D|CHRND_ENST00000457943.2_Intron	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	189					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		ATGCCAAGGAGAACCGCACCT	0.587000													15	94					0.00316338	0.00316566	1	1	0
ARHGEF10L	55160	broad.mit.edu	37	1	17953868	17953868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17953868C>T	ENST00000361221.3	+	15	1613	c.1454C>T	c.(1453-1455)tCg>tTg	p.S485L	ARHGEF10L_ENST00000167825.4_Missense_Mutation_p.S193L|ARHGEF10L_ENST00000452522.1_Missense_Mutation_p.S446L|ARHGEF10L_ENST00000375415.1_Missense_Mutation_p.S446L|ARHGEF10L_ENST00000434513.1_Missense_Mutation_p.S485L|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375420.3_Missense_Mutation_p.S243L|ARHGEF10L_ENST00000375408.3_Missense_Mutation_p.S263L	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	485	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GACAGGCTGTCGCTGCAGCTG	0.627000													18	60					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6087174	6087174	+	Silent	SNP	C	C	T	rs61753516		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6087174C>T	ENST00000409021.3	-	4	1256	c.807G>A	c.(805-807)ggG>ggA	p.G269G	JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000410077.2_Silent_p.G104G|JAKMIP1_ENST00000409831.1_Silent_p.G269G|JAKMIP1_ENST00000282924.5_Silent_p.G269G|JAKMIP1_ENST00000409371.3_Silent_p.G104G	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	269	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCACCATGTCCCCGATCCCGG	0.607000													11	41					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46312191	46312191	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:46312191G>A	ENST00000510861.1	-	6	731	c.559_splice	c.e6+1	p.S186_splice	GABRA2_ENST00000507069.1_Splice_Site_p.S186_splice|GABRA2_ENST00000356504.1_Splice_Site_p.S186_splice|GABRA2_ENST00000515082.1_Splice_Site_p.S186_splice|GABRA2_ENST00000381620.4_Splice_Site_p.S186_splice|GABRA2_ENST00000540012.1_Splice_Site_p.S131_splice|GABRA2_ENST00000514090.1_Splice_Site_p.S186_splice			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	186					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTACTTACAGCTGCCAAATT	0.393000													7	93					0	0	1	0	0
NCR3	259197	broad.mit.edu	37	6	31557903	31557903	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31557903C>T	ENST00000376073.4	-	2	307	c.43_splice	c.e2-1	p.G15_splice	NCR3_ENST00000491161.1_5'UTR|NCR3_ENST00000376072.3_Splice_Site_p.G15_splice|NCR3_ENST00000376071.4_Splice_Site_p.G15_splice|NCR3_ENST00000340027.5_Splice_Site_p.G15_splice	NM_001145466.1	NP_001138938.1	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	15					cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			cervix(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)	9						AGCACAGGATCCTGGGGGCAG	0.552000													20	38					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7670265	7670265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7670265C>T	ENST00000446248.2	+	2	403	c.302C>T	c.(301-303)cCc>cTc	p.P101L	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.P101L	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	101					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CCCCCCAACCCCTCTGCACTG	0.682000													25	129					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647268	121647268	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121647268G>A	ENST00000489711.1	+	15	1595	c.1206_splice	c.e15-1	p.E403_splice	SLC15A2_ENST00000295605.2_Splice_Site_p.E372_splice|SLC15A2_ENST00000465060.1_3'UTR	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	403					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TTGCTCTAAGGAAATGGCCCC	0.463000													49	163					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502456	91502456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91502456G>A	ENST00000266718.4	-	2	755	c.301C>T	c.(301-303)Ctt>Ttt	p.L101F	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	101				L -> V (in Ref. 1; AAA85268).	collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TTTTCTAGAAGGTTGTGATCT	0.388000													23	54					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54905628	54905628	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54905628G>A	ENST00000293373.6	+	8	856	c.777G>A	c.(775-777)tgG>tgA	p.W259*	NCKAP1L_ENST00000552211.1_3'UTR|NCKAP1L_ENST00000545638.2_Nonsense_Mutation_p.W209*	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	259					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TGGAGCGCTGGATTATCAGTA	0.413000													51	98					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604199	179604199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179604199C>T	ENST00000589042.1	-	48	13985	c.13761G>A	c.(13759-13761)gaG>gaA	p.E4587E	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.E4224E|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Silent_p.E4416E|TTN_ENST00000359218.5_Silent_p.E4349E|TTN_ENST00000591111.1_Silent_p.E4270E|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4270	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTAGCAACCTCCTCAGTAC	0.458000													18	72					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99723945	99723945	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:99723945C>T	ENST00000345514.2	-	2	556	c.290G>A	c.(289-291)aGc>aAc	p.S97N	BCL11B_ENST00000357195.3_Missense_Mutation_p.S97N|BCL11B_ENST00000443726.2_Intron	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	496						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GGGTGGCGGGCTGTCCTTGTC	0.597000			T	TLX3	T-ALL								7	92					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113287617	113287617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113287617G>A	ENST00000362072.3	-	4	844	c.500C>T	c.(499-501)tCc>tTc	p.S167F	DRD2_ENST00000544518.1_Missense_Mutation_p.S166F|DRD2_ENST00000542968.1_Missense_Mutation_p.S167F|DRD2_ENST00000346454.3_Missense_Mutation_p.S167F|DRD2_ENST00000538967.1_Missense_Mutation_p.S167F|DRD2_ENST00000535984.1_Intron|DRD2_ENST00000355319.2_Missense_Mutation_p.S167F	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	167					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GAGTGGGCAGGAGATGGTGAA	0.592000													8	33					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11862215	11862215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11862215G>A	ENST00000396516.2	-	11	1513	c.1316C>T	c.(1315-1317)aCc>aTc	p.T439I	ZC3H7A_ENST00000355758.4_Missense_Mutation_p.T439I			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	439						nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						CAATTCATGGGTTCCTTCGAG	0.408000													55	126					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607827	84607827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84607827G>A	ENST00000344803.2	+	4	2489	c.2442G>A	c.(2440-2442)ggG>ggA	p.G814G		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		ATCTGTCAGGGAATGACTCAG	0.453000													24	42					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61570930	61570930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61570930G>A	ENST00000577647.1	+	9	1369	c.1324G>A	c.(1324-1326)Gag>Aag	p.E442K	ACE_ENST00000413513.3_Missense_Mutation_p.E442K|ACE_ENST00000290866.4_Missense_Mutation_p.E1016K|ACE_ENST00000428043.1_Missense_Mutation_p.E1016K|ACE_ENST00000490216.2_Missense_Mutation_p.E442K|ACE_ENST00000290863.6_Missense_Mutation_p.E442K|ACE_ENST00000421982.2_Missense_Mutation_p.E262K			P12821	ACE_HUMAN	angiotensin I converting enzyme	1016	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CGGCTTCCATGAGGCCATTGG	0.592000													10	74					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95606880	95606880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:95606880G>A	ENST00000324972.6	+	7	791	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	DYNC1I1_ENST00000447467.2_Missense_Mutation_p.E183K|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.E180K|DYNC1I1_ENST00000359388.4_Missense_Mutation_p.E163K|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.E163K|DYNC1I1_ENST00000457059.1_Missense_Mutation_p.E183K	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	200					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CTCAGAACTGGAAAATCAGGA	0.323000													5	41					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	65016088	65016088	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:65016088G>A	ENST00000394156.3	-	8	1569	c.1116C>T	c.(1114-1116)atC>atT	p.I372I	CDH11_ENST00000268603.4_Silent_p.I372I|CDH11_ENST00000566827.1_Silent_p.I246I			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	372	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CTTCTACTGAGATCTTGACGG	0.517000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			25	94					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97810277	97810277	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97810277C>T	ENST00000420699.2	+	9	1168	c.924C>T	c.(922-924)gcC>gcT	p.A308A	ANKRD36_ENST00000461153.2_Silent_p.A308A	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	308										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						AACAACCGGCCTTGAAGGTAT	0.318000													9	29					0	0	1	0	0
REXO1	57455	broad.mit.edu	37	19	1823746	1823746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1823746G>A	ENST00000170168.4	-	4	2149	c.2055C>T	c.(2053-2055)gcC>gcT	p.A685A	CTB-31O20.4_ENST00000587741.1_RNA|CTB-31O20.4_ENST00000593201.1_RNA	NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	685						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGGGGCCGGGCCGGGGGCA	0.741000													4	3					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45837921	45837921	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45837921C>T	ENST00000397928.1	+	21	3703	c.3258C>T	c.(3256-3258)ctC>ctT	p.L1086L	TRPM2_ENST00000397932.2_Silent_p.L1086L|TRPM2_ENST00000300482.5_Silent_p.L1086L|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Silent_p.L1066L	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1086						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						ccTTCATCCTCCTCAGCCACC	0.627000													43	68					0	0	1	0	0
SLC9A7	84679	broad.mit.edu	37	X	46522065	46522065	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:46522065C>T	ENST00000328306.4	-	6	832	c.807G>A	c.(805-807)gcG>gcA	p.A269A		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	269					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						CATTAAATATCGCCAGCACAG	0.403000													20	16					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111166	55111166	+	Silent	SNP	C	C	T	rs144421988	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55111166C>T	ENST00000314721.2	+	1	540	c.490C>T	c.(490-492)Cta>Tta	p.L164L		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						TCTGTACAGTCTACCAATCTG	0.443000													31	145					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24822131	24822131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24822131G>A	ENST00000376451.2	+	11	2688	c.2428G>A	c.(2428-2430)Gaa>Aaa	p.E810K	KIAA1217_ENST00000307544.6_Missense_Mutation_p.E810K|KIAA1217_ENST00000458595.1_Missense_Mutation_p.E1092K|KIAA1217_ENST00000396446.1_Missense_Mutation_p.E810K|KIAA1217_ENST00000376462.1_Missense_Mutation_p.E1047K|KIAA1217_ENST00000396445.1_Missense_Mutation_p.E810K|KIAA1217_ENST00000376452.3_Missense_Mutation_p.E1091K|KIAA1217_ENST00000376454.3_Missense_Mutation_p.E1127K			Q5T5P2	SKT_HUMAN	KIAA1217	1127					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGAGGAAGAAGAAGAAGAAGG	0.552000													15	60					0	0	1	0	0
DECR2	26063	broad.mit.edu	37	16	461033	461033	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:461033C>T	ENST00000219481.5	+	7	756	c.618C>T	c.(616-618)ctC>ctT	p.L206L	DECR2_ENST00000461947.1_3'UTR|DECR2_ENST00000424398.2_Silent_p.L194L	NM_020664.3	NP_065715.1	Q9NUI1	DECR2_HUMAN	2,4-dienoyl CoA reductase 2, peroxisomal	206						peroxisome	2,4-dienoyl-CoA reductase (NADPH) activity|binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)	9		Hepatocellular(16;0.00015)				TCAACAGCCTCGCCCCTGGCC	0.642000													4	11					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84363153	84363153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84363153C>T	ENST00000509231.1	-	1	901	c.822G>A	c.(820-822)atG>atA	p.M274I	SATL1_ENST00000395409.3_Missense_Mutation_p.M87I|SATL1_ENST00000332921.5_Missense_Mutation_p.M87I			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	87	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						GGTTCATGTCCATTTGGTTCA	0.448000													19	52					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98155083	98155083	+	Silent	SNP	C	C	T	rs151335014		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98155083C>T	ENST00000357947.3	-	13	1812	c.1587G>A	c.(1585-1587)acG>acA	p.T529T	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	529	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.T529T(1)		NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CACTCTCTTCCGTGGGGCCAT	0.527000													29	72					0	0	1	0	0
IGHV4-34	28395	broad.mit.edu	37	14	106829885	106829885	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106829885G>A	ENST00000390616.2	-	0	108																											GCTGCACCTGGGACAGGACCC	0.562000													20	44					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38847158	38847158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38847158G>A	ENST00000409235.3	+	10	1285	c.1170G>A	c.(1168-1170)caG>caA	p.Q390Q	CATSPERG_ENST00000410018.1_Silent_p.Q390Q|CATSPERG_ENST00000215069.4_Intron	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	390					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						TGCCCAGGCAGTGGTCTGTGT	0.607000													23	78					0	0	1	0	0
F11R	50848	broad.mit.edu	37	1	160969689	160969689	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160969689G>A	ENST00000368026.6	-	6	945	c.671C>T	c.(670-672)tCa>tTa	p.S224L	F11R_ENST00000537746.1_Missense_Mutation_p.S175L|F11R_ENST00000289779.3_3'UTR	NM_016946.4	NP_058642.1	Q9Y624	JAM1_HUMAN	F11 receptor	224	Ig-like V-type 2.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)	12	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			CACAGCATTTGAAGTCATGGG	0.517000													21	73					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168103648	168103648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168103648G>A	ENST00000409195.1	+	9	5835	c.5746G>A	c.(5746-5748)Gag>Aag	p.E1916K	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1916K|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1694K	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1741					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TCTGAAAAAGGAGCTTCTCAA	0.353000													16	51					0	0	1	0	0
AICDA	57379	broad.mit.edu	37	12	8757480	8757480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8757480C>T	ENST00000229335.6	-	4	569	c.466G>A	c.(466-468)Gaa>Aaa	p.E156K	AICDA_ENST00000537228.1_Missense_Mutation_p.E146K	NM_020661.2	NP_065712.1	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	156					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					AAAGTTCTTTCGTGGTTTTCT	0.423000													45	92					0	0	1	0	0
EIF3B	8662	broad.mit.edu	37	7	2402289	2402289	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2402289C>T	ENST00000360876.4	+	3	758	c.702C>T	c.(700-702)ttC>ttT	p.F234F	EIF3B_ENST00000397011.2_Silent_p.F234F	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	234	RRM.|Sufficient for interaction with EIF3E.|Sufficient for interaction with EIF3J.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GGTATATTTTCCTGGAGTACG	0.587000													22	48					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38950158	38950158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38950158C>T	ENST00000359357.3	+	84	12474	c.12220C>T	c.(12220-12222)Ccc>Tcc	p.P4074S	DNAH8_ENST00000441566.1_Missense_Mutation_p.P4038S					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATGGAATATTCCCTACGAATT	0.353000													15	207					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627648	21627648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:21627648G>A	ENST00000425654.2	+	19	2995	c.2515G>A	c.(2515-2517)Gat>Aat	p.D839N	CNKSR2_ENST00000279451.4_Missense_Mutation_p.D869N|CNKSR2_ENST00000379510.3_Missense_Mutation_p.D869N|CNKSR2_ENST00000543067.1_Missense_Mutation_p.D820N	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	869					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TGACCCACAGGATGACGTGCA	0.522000													34	21					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74043403	74043403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74043403G>A	ENST00000409561.1	+	3	2174	c.2053G>A	c.(2053-2055)Gag>Aag	p.E685K		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	685										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TAAAGGCCCGGAGAAAATTCA	0.512000													7	70					0	0	1	0	0
KRR1	11103	broad.mit.edu	37	12	75897712	75897712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:75897712G>A	ENST00000229214.4	-	7	826	c.803C>T	c.(802-804)cCa>cTa	p.P268L	KRR1_ENST00000438169.2_Intron	NM_007043.6	NP_008974.5	Q13601	KRR1_HUMAN	KRR1, small subunit (SSU) processome component, homolog (yeast)	268	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	11						TGGTGGGAATGGCGTATATTC	0.343000													24	204					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31317934	31317934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31317934G>A	ENST00000265071.2	+	11	2050	c.1785G>A	c.(1783-1785)ggG>ggA	p.G595G	CDH6_ENST00000514738.1_Silent_p.G540G	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	595	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ACCACCACGGGAACATGCAAT	0.572000													23	42					0	0	1	0	0
TUBA1B	10376	broad.mit.edu	37	12	49523142	49523142	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49523142G>A	ENST00000336023.5	-	3	352	c.258C>T	c.(256-258)ctC>ctT	p.L86L	RP11-386G11.10_ENST00000547387.1_RNA	NM_006082.2	NP_006073.2	P68363	TBA1B_HUMAN	tubulin, alpha 1b	86					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(4)	12						CAGGGTGGAAGAGCTGGCGGT	0.557000													51	106					0	0	1	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43694429	43694429	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:43694429C>T	ENST00000395809.1	-	9	3490	c.984G>A	c.(982-984)ctG>ctA	p.L328L	RASGEF1A_ENST00000374459.1_Silent_p.L336L|RASGEF1A_ENST00000395810.1_Silent_p.L328L			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	328	Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						AAGTTTTCTTCAGCCTTGCCA	0.622000													49	87					0	0	1	0	0
BICD2	23299	broad.mit.edu	37	9	95480899	95480899	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95480899G>A	ENST00000356884.6	-	5	2095	c.2028C>T	c.(2026-2028)atC>atT	p.I676I	BICD2_ENST00000375512.3_Silent_p.I676I	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	676	Interacts with RAB6A (By similarity).				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						TCAGCTTGAGGATCTCCTCCA	0.642000													22	183					0	0	1	0	0
GNAT3	346562	broad.mit.edu	37	7	80108268	80108268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:80108268C>T	ENST00000398291.3	-	4	443	c.350G>A	c.(349-351)gGt>gAt	p.G117D	CD36_ENST00000435819.1_Intron	NM_001102386.1	NP_001095856.1	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha transducing 3	117					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	9						TGTCATGCCACCATCTTCCAG	0.418000													33	103					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113943683	113943683	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113943683G>A	ENST00000245796.6	+	5	1674	c.1479G>A	c.(1477-1479)ttG>ttA	p.L493L	PSD4_ENST00000441564.2_Silent_p.L465L	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	493					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTTCACTCTTGGAGACGGATG	0.567000													26	68					0	0	1	0	0
SENP8	123228	broad.mit.edu	37	15	72432043	72432043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72432043C>T	ENST00000544411.1	+	3	566	c.79C>T	c.(79-81)Ctc>Ttc	p.L27F	SENP8_ENST00000542035.2_Missense_Mutation_p.L27F|SENP8_ENST00000544171.1_Missense_Mutation_p.L27F|SENP8_ENST00000340912.4_Missense_Mutation_p.L27F	NM_001172109.1|NM_001172110.1	NP_001165580.1|NP_001165581.1	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	27	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			breast(1)|kidney(2)|lung(1)|ovary(1)|skin(1)	6						GCCAAGCTGGCTCAATGACCA	0.488000													66	205					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124756633	124756633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124756633C>T	ENST00000306534.3	-	16	3006	c.2521G>A	c.(2521-2523)Gac>Aac	p.D841N	RP11-664I21.5_ENST00000524453.1_RNA|ROBO4_ENST00000533054.1_Missense_Mutation_p.D696N	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	841					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CTGCCCATGTCCGTGAACTCT	0.652000													13	41					0	0	1	0	0
ZNF702P	79986	broad.mit.edu	37	19	53473988	53473988	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53473988C>T	ENST00000600068.1	-	0	377				ZNF702P_ENST00000270443.4_RNA																							AAGGAAAAATCTCCAGTGTGA	0.408000													13	132					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124117644	124117644	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124117644G>A	ENST00000360013.3	+	13	2393	c.2266G>A	c.(2266-2268)Gag>Aag	p.E756K	KALRN_ENST00000240874.3_Missense_Mutation_p.E756K|KALRN_ENST00000460856.1_Missense_Mutation_p.E756K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	756					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GCAGATGGAGGAGCTGTTCCA	0.582000													33	86					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585896	179585896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179585896G>A	ENST00000589042.1	-	79	23074	c.22850C>T	c.(22849-22851)tCa>tTa	p.S7617L	TTN_ENST00000342992.6_Missense_Mutation_p.S6373L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S7300L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7300	Ig-like 58.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAACTTTTGAAGCTTCTAA	0.348000													15	35					0	0	1	0	0
TRIM40	135644	broad.mit.edu	37	6	30105149	30105149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30105149C>T	ENST00000396581.1	+	2	722	c.336C>T	c.(334-336)agC>agT	p.S112S	TRIM40_ENST00000376724.2_Silent_p.S112S|TRIM40_ENST00000307859.4_Silent_p.S112S			Q6P9F5	TRI40_HUMAN	tripartite motif containing 40	112						intracellular	zinc ion binding			ovary(1)	1						ATGCCCTCAGCCACTACAAGG	0.547000													11	82					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2542544	2542544	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2542544C>T	ENST00000358864.1	+	4	457	c.442C>T	c.(442-444)Ctg>Ttg	p.L148L		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	148	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGGGGAGTCCCTGTCCGAGGA	0.607000													24	65					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51379750	51379750	+	Missense_Mutation	SNP	C	C	T	rs147080743		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51379750C>T	ENST00000325321.3	+	3	454	c.229C>T	c.(229-231)Cgg>Tgg	p.R77W	KLK2_ENST00000358049.4_Missense_Mutation_p.R77W|KLK2_ENST00000391810.2_5'UTR|KLK2_ENST00000597509.1_3'UTR			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	77	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		CTGGCTGGGTCGGCACAACCT	0.567000			T	ETV4	prostate								16	41					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553997	140553997	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140553997C>T	ENST00000231137.3	+	1	1755	c.1581C>T	c.(1579-1581)ttC>ttT	p.F527F		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		527	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAGGCGTTCGAGTTCCGCG	0.701000													54	106					0	0	1	0	0
WLS	79971	broad.mit.edu	37	1	68619310	68619310	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:68619310G>A	ENST00000262348.4	-	5	946	c.693C>T	c.(691-693)acC>acT	p.T231T	GNG12-AS1_ENST00000420587.1_RNA|GNG12-AS1_ENST00000413628.1_RNA|WLS_ENST00000370976.3_Silent_p.T140T|WLS_ENST00000540432.1_Silent_p.T231T|WLS_ENST00000354777.2_Silent_p.T229T|WLS_ENST00000491811.1_5'UTR	NM_024911.6	NP_079187.3	Q5T9L3	WLS_HUMAN	wntless Wnt ligand secretion mediator	231	Interacts with Wnt proteins (By similarity).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)|prostate(3)|urinary_tract(1)	20						ACCACACCTTGGTGAAGCCTC	0.463000													19	49					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16892697	16892697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:16892697G>A	ENST00000355661.3	-	4	264	c.254C>T	c.(253-255)cCt>cTt	p.P85L	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.P85L|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.P85L			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	85	WW 2.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TCCCGTCACAGGATGCCTGAA	0.428000													16	69					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160277257	160277257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:160277257C>T	ENST00000264431.4	+	23	4840	c.4421C>T	c.(4420-4422)tCt>tTt	p.S1474F		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1474					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CCGAACGAGTCTGACCCGCGC	0.537000													15	33					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203194880	203194880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203194880G>A	ENST00000367229.1	-	3	208	c.174C>T	c.(172-174)ttC>ttT	p.F58F	CHIT1_ENST00000535569.1_Silent_p.F68F|CHIT1_ENST00000484834.1_5'UTR|CHIT1_ENST00000255427.3_Silent_p.F58F	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	58					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						TCATGCCAGCGAAGGCGTAGA	0.572000													7	84					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6381394	6381394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6381394G>A	ENST00000394456.5	-	9	1458	c.994C>T	c.(994-996)Ccg>Tcg	p.P332S	GTF2F1_ENST00000429701.2_Missense_Mutation_p.P247S	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	332	Glu-rich.				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						TTCTCCTGCGGGGTGGGTGcc	0.652000													5	22					0	0	1	0	0
ZNF662	389114	broad.mit.edu	37	3	42956100	42956100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42956100C>T	ENST00000541208.1	+	5	904	c.535C>T	c.(535-537)Ctt>Ttt	p.L179F	ZNF662_ENST00000328199.6_Missense_Mutation_p.L205F|ZNF662_ENST00000422021.1_Intron|KRBOX1_ENST00000426937.1_Intron|ZNF662_ENST00000440367.2_Missense_Mutation_p.L179F			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		CAATAACCTCCTTGGTATACA	0.348000													31	71					0	0	1	0	0
EFHD1	80303	broad.mit.edu	37	2	233546349	233546349	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233546349G>A	ENST00000264059.3	+	4	1117	c.640G>A	c.(640-642)Gat>Aat	p.D214N	EFHD1_ENST00000410095.1_Missense_Mutation_p.D102N|EFHD1_ENST00000409613.1_Missense_Mutation_p.D118N|EFHD1_ENST00000409708.1_Missense_Mutation_p.D102N	NM_025202.3	NP_079478.1	Q9BUP0	EFHD1_HUMAN	EF-hand domain family, member D1	214							calcium ion binding|protein binding			NS(1)|breast(1)|large_intestine(2)|lung(3)	7		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Breast(86;0.0199)|Renal(207;0.025)		Epithelial(121;2.08e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00825)|Lung(119;0.0101)		AGCTGAGCAAGATGAGCGGAA	0.542000													58	101					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67333348	67333348	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67333348G>A	ENST00000304372.5	-	6	959	c.904C>T	c.(904-906)Ctg>Ttg	p.L302L	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	302						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		AGCTGGCCCAGCGCAGAGTCC	0.627000													31	78					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9523353	9523353	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9523353G>A	ENST00000378429.3	-	10	2430	c.1884C>T	c.(1882-1884)tcC>tcT	p.S628S	PAK7_ENST00000378423.1_Silent_p.S628S|PAK7_ENST00000353224.5_Silent_p.S628S	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	628	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TGATCCCGAGGGACCAGATGT	0.517000													19	76					0	0	1	0	0
AQP4	361	broad.mit.edu	37	18	24442461	24442461	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:24442461G>A	ENST00000383168.4	-	2	260	c.132C>T	c.(130-132)gcC>gcT	p.A44A	AQP4_ENST00000581374.1_Silent_p.A22A|AQP4_ENST00000440832.3_Silent_p.A22A|AQP4-AS1_ENST00000582605.1_RNA|AQP4-AS1_ENST00000579964.1_RNA	NM_001650.4|NM_004028.3	NP_001641.1|NP_004019.1	P55087	AQP4_HUMAN	aquaporin 4	44					cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity			kidney(2)|large_intestine(3)|lung(5)|skin(1)	11	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					AAATAAGCATGGCCAGAAATT	0.488000													83	186					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360640	27360640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27360640G>A	ENST00000335524.3	-	3	1083	c.558C>T	c.(556-558)tcC>tcT	p.S186S		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	186										cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGGGACCCGGACCCAGTGT	0.637000													21	60					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233393906	233393906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233393906C>T	ENST00000258229.8	-	5	1936	c.1702G>A	c.(1702-1704)Gga>Aga	p.G568R	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	568						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GGCATTTGTCCTTCCTTAGCC	0.423000													14	54					0	0	1	0	0
MOGAT1	116255	broad.mit.edu	37	2	223559950	223559950	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:223559950G>A	ENST00000446656.3	+	5	796	c.796G>A	c.(796-798)Gga>Aga	p.G266R		NM_058165.2	NP_477513.2	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	266					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)|cervix(1)|endometrium(1)|lung(5)|urinary_tract(1)	9		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		TCATGCCAGGGGAGTTTTTCA	0.388000													5	27					0	0	1	0	0
HOXC4	3221	broad.mit.edu	37	12	54448070	54448070	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54448070C>T	ENST00000430889.2	+	1	410	c.364C>T	c.(364-366)Ccc>Tcc	p.P122S	HOXC4_ENST00000303406.4_Missense_Mutation_p.P122S	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	122						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						CCAGCCAGCCCCCGACCATCC	0.637000													10	25					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44418275	44418275	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44418275T>A	ENST00000269973.5	-	10	2403	c.1313A>T	c.(1312-1314)cAt>cTt	p.H438L	RP11-15A1.2_ENST00000586247.1_RNA|ZNF45_ENST00000589703.1_Missense_Mutation_p.H438L	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	438					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						TTCCCCTGTATGGACTCTAAA	0.478000													32	110					0	0	1	0	0
KLF11	8462	broad.mit.edu	37	2	10187786	10187786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:10187786C>T	ENST00000535335.1	+	3	487	c.271C>T	c.(271-273)Cct>Tct	p.P91S	KLF11_ENST00000305883.1_Missense_Mutation_p.P108S|KLF11_ENST00000540845.1_Missense_Mutation_p.P91S	NM_001177718.1	NP_001171189.1	O14901	KLF11_HUMAN	Kruppel-like factor 11	108					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GTGCATAACTCCTCCTCAGAG	0.413000													12	75					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28497335	28497335	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28497335C>T	ENST00000412168.2	+	2	284	c.195C>T	c.(193-195)ctC>ctT	p.L65L	GPX5_ENST00000442674.2_3'UTR|GPX5_ENST00000469384.1_Silent_p.L65L	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	65					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	AGCACATCCTCTTCGTCAACG	0.438000													37	68					0	0	1	0	0
OFCC1	266553	broad.mit.edu	37	6	9900697	9900697	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:9900697C>T	ENST00000316020.6	-	6	572	c.573G>A	c.(571-573)ctG>ctA	p.L191L	OFCC1_ENST00000472329.1_5'UTR					orofacial cleft 1 candidate 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)	11	Ovarian(93;0.0473)|Breast(50;0.201)	all_hematologic(90;0.124)				CTTCAGAATTCAGAGTCTCCT	0.443000													46	112					0	0	1	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134497253	134497253	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:134497253G>A	ENST00000372195.1	-	11	2078	c.1835C>T	c.(1834-1836)tCc>tTc	p.S612F	RAPGEF1_ENST00000372189.3_Missense_Mutation_p.S595F|RAPGEF1_ENST00000372190.3_Missense_Mutation_p.S613F			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	595					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CCCACTGAAGGAGTCGCTGAA	0.612000													6	15					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40648100	40648100	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:40648100G>A	ENST00000342449.3	-	12	1222	c.1145_splice	c.e12+1	p.R382_splice	BRWD1_ENST00000380800.3_Splice_Site_p.R382_splice|BRWD1_ENST00000333229.2_Splice_Site_p.R382_splice	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CACACTTACCGATCACCATTG	0.328000													39	97					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179745905	179745905	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179745905G>A	ENST00000253778.8	-	10	1015	c.846C>T	c.(844-846)atC>atT	p.I282I	GFPT2_ENST00000520165.1_5'UTR	NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	282	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CCACTGCGGCGATGTCATCGT	0.582000													19	32					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57731603	57731603	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57731603A>T	ENST00000281282.5	+	2	1484	c.1406A>T	c.(1405-1407)aAa>aTa	p.K469I		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	469	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		ATAGATGGGAAAGTTCTGGAA	0.582000													22	66					0	0	1	0	0
RAD51AP1	10635	broad.mit.edu	37	12	4662198	4662198	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4662198C>T	ENST00000228843.9	+	8	707	c.657C>T	c.(655-657)gaC>gaT	p.D219D	RAD51AP1_ENST00000544931.1_3'UTR|RAD51AP1_ENST00000544927.1_Silent_p.D202D|RAD51AP1_ENST00000352618.4_Silent_p.D202D|RAD51AP1_ENST00000321524.7_Silent_p.D219D|RAD51AP1_ENST00000543041.1_Silent_p.D84D	NM_001130862.1	NP_001124334.1	Q96B01	R51A1_HUMAN	RAD51 associated protein 1	219					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|RNA binding|single-stranded DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			AGGATAATGACGAAGACTTCT	0.313000													10	37					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139189308	139189308	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139189308G>A	ENST00000274710.3	+	2	488	c.283G>A	c.(283-285)Gag>Aag	p.E95K		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	95					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATTCAGCGGAGTCCAGGCC	0.612000													34	109					0	0	1	0	0
BIRC5	332	broad.mit.edu	37	17	76219712	76219712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76219712C>T	ENST00000374948.2	+	3	441	c.388C>T	c.(388-390)Cct>Tct	p.P130S	AC087645.1_ENST00000600484.1_Missense_Mutation_p.E190K|BIRC5_ENST00000301633.4_3'UTR|BIRC5_ENST00000589892.1_3'UTR|BIRC5_ENST00000350051.3_3'UTR	NM_001012270.1	NP_001012270.1	O15392	BIRC5_HUMAN	baculoviral IAP repeat containing 5	0					anti-apoptosis|apoptosis|cell division|chromosome segregation|cytokinesis|establishment of chromosome localization|G2/M transition of mitotic cell cycle|mitosis|mitotic prometaphase|positive regulation of exit from mitosis|positive regulation of mitotic cell cycle|protein complex localization|spindle checkpoint	centriole|chromosome passenger complex|chromosome, centromeric region|cytoplasm|cytoplasmic microtubule|cytosol|interphase microtubule organizing center|midbody|nuclear chromosome|spindle|spindle microtubule	caspase inhibitor activity|chaperone binding|cobalt ion binding|cofactor binding|cysteine-type endopeptidase inhibitor activity|metal ion binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|Ran GTPase binding|zinc ion binding			kidney(1)|urinary_tract(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.153)			CACCAGCCTTCCTGTGGGCCC	0.527000													11	23					0	0	1	0	0
NOX5	79400	broad.mit.edu	37	15	69329379	69329379	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:69329379G>A	ENST00000260364.5	+	9	1447	c.1146G>A	c.(1144-1146)tgG>tgA	p.W382*	NOX5_ENST00000455873.3_Nonsense_Mutation_p.W365*|NOX5_ENST00000448182.3_Nonsense_Mutation_p.W354*|NOX5_ENST00000530406.2_Nonsense_Mutation_p.W372*|NOX5_ENST00000388866.3_Nonsense_Mutation_p.W400*			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	400	Ferric oxidoreductase.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						TGTTCTATTGGACTCACCTGT	0.557000													112	151					0	0	1	0	0
COG6	57511	broad.mit.edu	37	13	40239278	40239278	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:40239278C>T	ENST00000416691.1	+	4	515	c.415C>T	c.(415-417)Ctt>Ttt	p.L139F	COG6_ENST00000455146.3_Missense_Mutation_p.L139F	NM_001145079.1	NP_001138551.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6	139					protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		AACCACTAAGCTTCAATCTGA	0.259000													27	71					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59323895	59323895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:59323895C>T	ENST00000348370.4	+	2	1307	c.874C>T	c.(874-876)Ccc>Tcc	p.P292S	RNF111_ENST00000434298.1_Missense_Mutation_p.P292S|RNF111_ENST00000557998.1_Missense_Mutation_p.P292S|RNF111_ENST00000559209.1_Missense_Mutation_p.P292S|RNF111_ENST00000561186.1_Missense_Mutation_p.P292S	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	292	Interaction with AXIN1.|Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		TCCAGCTGTTCCCTCAGGTAA	0.368000													37	92					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881631	26881631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:26881631C>T	ENST00000231021.4	-	12	2156	c.1984G>A	c.(1984-1986)Gaa>Aaa	p.E662K		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	662					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CCGCCGCCTTCATCGTTGTAG	0.438000													72	129					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15729966	15729966	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15729966T>A	ENST00000378076.3	-	3	768	c.415A>T	c.(415-417)Aca>Tca	p.T139S		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	139					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						GCTTTCACTGTTGCTCCAAAC	0.423000													20	126					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78695312	78695312	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:78695312G>A	ENST00000436010.2	-	19	3748	c.2751C>T	c.(2749-2751)gtC>gtT	p.V917V	ROBO1_ENST00000495273.1_Silent_p.V911V|ROBO1_ENST00000464233.1_Silent_p.V956V|ROBO1_ENST00000467549.1_Silent_p.V911V			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	956					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CTCCACTGCTGACAGCTTCGC	0.348000													27	83					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419851	130419851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:130419851G>A	ENST00000370904.1	-	10	1152	c.242C>T	c.(241-243)tCa>tTa	p.S81L	IGSF1_ENST00000370903.3_Missense_Mutation_p.S90L|IGSF1_ENST00000370901.4_Missense_Mutation_p.S90L|IGSF1_ENST00000370910.1_Missense_Mutation_p.S81L|IGSF1_ENST00000370900.1_Missense_Mutation_p.S90L|IGSF1_ENST00000361420.3_Missense_Mutation_p.S90L			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	90	Ig-like C2-type 1.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TATAAGGAATGAAACTTGGAA	0.512000													55	52					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41100936	41100936	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:41100936C>T	ENST00000373198.3	-	8	1655	c.1420G>A	c.(1420-1422)Gag>Aag	p.E474K	PTPRT_ENST00000373193.3_Missense_Mutation_p.E474K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E474K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E474K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E474K|PTPRT_ENST00000373187.1_Missense_Mutation_p.E474K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E474K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	474	Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACCAGCTCCTCGCTCTCCATT	0.587000													14	96					0	0	1	0	0
PAX8	7849	broad.mit.edu	37	2	113999206	113999206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113999206G>A	ENST00000429538.3	-	7	893	c.699C>T	c.(697-699)ctC>ctT	p.L233L	AC016683.6_ENST00000333145.5_RNA|AC016683.6_ENST00000436293.2_RNA|PAX8_ENST00000263335.7_Silent_p.L233L|AC016683.6_ENST00000445745.1_RNA|AC016683.6_ENST00000451179.1_RNA|PAX8_ENST00000397647.3_Silent_p.L233L|PAX8_ENST00000348715.5_Silent_p.L233L|AC016683.6_ENST00000556070.1_RNA|AC016683.6_ENST00000553869.2_RNA|AC016683.6_ENST00000422956.1_RNA|PAX8_ENST00000263334.5_Silent_p.L233L	NM_003466.3	NP_003457.1	Q06710	PAX8_HUMAN	paired box 8	233					branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity		PAX8/PPARG(117)	breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|skin(1)	20						CGAGCGGCTCGAGGTGGTGCT	0.627000			T	PPARG	follicular thyroid		Thyroid dysgenesis						24	24					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192595	152192595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152192595C>T	ENST00000368801.2	-	3	1585	c.1510G>A	c.(1510-1512)Ggt>Agt	p.G504S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	504					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCGTTCACCCCTAGATGAC	0.552000													109	339					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23065577	23065577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23065577G>A	ENST00000246006.4	-	1	1400	c.1253C>T	c.(1252-1254)gCc>gTc	p.A418V		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	418	EGF-like 4; calcium-binding (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTCCTCCCCGGCCAGGACGTA	0.637000													33	62					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139890497	139890497	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139890497C>T	ENST00000303045.6	-	3	600	c.154G>A	c.(154-156)Gag>Aag	p.E52K	COL22A1_ENST00000435777.1_Missense_Mutation_p.E52K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	52	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TCAAAGTCCTCCTTGCCCACG	0.637000										HNSCC(7;0.00092)			5	12					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55655610	55655610	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55655610G>A	ENST00000449290.2	+	4	702	c.610G>A	c.(610-612)Gag>Aag	p.E204K	TRIM51_ENST00000244891.3_Missense_Mutation_p.E61K	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	204						intracellular	zinc ion binding	p.E204K(1)|p.E45K(1)									GCTGCGAAAGGAGGGCGAGGA	0.423000													33	70					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061161	9061161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9061161G>A	ENST00000397910.4	-	3	26488	c.26285C>T	c.(26284-26286)tCa>tTa	p.S8762L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8764	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATTTCTGGTGATATTGTGGA	0.502000													20	80					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832883	61832883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61832883C>T	ENST00000280772.1	-	37	7947	c.7756G>A	c.(7756-7758)Gaa>Aaa	p.E2586K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2586					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTCAGTTTTTCTTCAGCCTCC	0.433000													44	93					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3000022	3000022	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3000022G>A	ENST00000520002.1	-	42	6764	c.6209C>T	c.(6208-6210)tCg>tTg	p.S2070L	CSMD1_ENST00000542608.1_Missense_Mutation_p.S2069L|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000539096.1_Missense_Mutation_p.S2069L|CSMD1_ENST00000537824.1_Missense_Mutation_p.S2069L|CSMD1_ENST00000602723.1_Missense_Mutation_p.S2070L|CSMD1_ENST00000400186.3_Missense_Mutation_p.S2070L|CSMD1_ENST00000602557.1_Missense_Mutation_p.S2070L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2070	CUB 12.					integral to membrane		p.S2069L(1)|p.S1798L(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCGGTTTTGCGAATGGTCACT	0.453000													11	43					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50216681	50216681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50216681C>T	ENST00000392518.4	+	20	2603	c.2231C>T	c.(2230-2232)tCc>tTc	p.S744F	CPT1C_ENST00000323446.5_Missense_Mutation_p.S744F|CPT1C_ENST00000598293.1_Missense_Mutation_p.S744F|CPT1C_ENST00000354199.5_Missense_Mutation_p.S655F|CPT1C_ENST00000405931.2_Missense_Mutation_p.S733F	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	744					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTCCAGGATTCCCACAGGCTG	0.592000													22	72					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97851545	97851545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97851545G>A	ENST00000354565.2	+	1	4	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						TGAGGACATGGAAGAGGAAAA	0.398000													62	147					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10114359	10114359	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10114359G>A	ENST00000264828.3	-	6	816	c.731C>T	c.(730-732)cCt>cTt	p.P244L		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	244	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CTTCCGCCGAGGACGAGGGGT	0.577000													9	79					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10465377	10465377	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10465377C>T	ENST00000382483.3	-	4	6454	c.6231G>A	c.(6229-6231)gaG>gaA	p.E2077E		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2077					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTGGGTGGGCCTCCCCTTCTG	0.642000													26	244					0	0	1	0	0
TSPAN8	7103	broad.mit.edu	37	12	71531781	71531781	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71531781C>T	ENST00000393330.2	-	9	948	c.396G>A	c.(394-396)ggG>ggA	p.G132G	TSPAN8_ENST00000552128.1_Silent_p.G49G|TSPAN8_ENST00000546561.1_Silent_p.G132G|TSPAN8_ENST00000247829.3_Silent_p.G132G			P19075	TSN8_HUMAN	tetraspanin 8	132					protein glycosylation	integral to membrane|lysosome	signal transducer activity			breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(7)|skin(3)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			TTTCACTTTCCCCTGTGGCGC	0.353000													33	114					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432226	140432226	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140432226C>T	ENST00000306549.3	+	1	1248	c.1171C>T	c.(1171-1173)Ccc>Tcc	p.P391S		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		391	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAAGACCTTCCCTTTGTAAT	0.473000													41	77					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65263284	65263284	+	Silent	SNP	G	G	A	rs150377252		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65263284G>A	ENST00000389722.3	-	10	1385	c.1332C>T	c.(1330-1332)ctC>ctT	p.L444L	SPTB_ENST00000389720.3_Silent_p.L444L|SPTB_ENST00000389721.5_Silent_p.L444L|SPTB_ENST00000556626.1_Silent_p.L444L|SPTB_ENST00000542895.1_Silent_p.L444L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	444					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTGGGCCACGAGGCGCTGGT	0.587000													14	76					0	0	1	0	0
DCAF6	55827	broad.mit.edu	37	1	168014196	168014196	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168014196C>T	ENST00000367840.3	+	16	2083	c.1989C>T	c.(1987-1989)gaC>gaT	p.D663D	DCAF6_ENST00000312263.6_Silent_p.D586D|DCAF6_ENST00000432587.2_Silent_p.D632D|DCAF6_ENST00000367843.3_Silent_p.D606D	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	603					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						AAAGAAATGACCTCAATCTTG	0.428000													53	172					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56342232	56342232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56342232C>T	ENST00000262290.4	+	10	1732	c.1416C>T	c.(1414-1416)ccC>ccT	p.P472P	LPO_ENST00000582328.1_Silent_p.P389P|LPO_ENST00000543544.1_Silent_p.P413P|LPO_ENST00000421678.2_Silent_p.P389P	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	472					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						TGGAGGTCCCCTCTAGTATGT	0.517000													28	59					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47841699	47841699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47841699C>T	ENST00000371764.4	+	6	665	c.656C>T	c.(655-657)tCg>tTg	p.S219L	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	219						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAAAACCTCTCGTTCCAGGAC	0.418000													36	118					0	0	1	0	0
RNF122	79845	broad.mit.edu	37	8	33416195	33416195	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:33416195G>A	ENST00000256257.1	-	2	521	c.120C>T	c.(118-120)gtC>gtT	p.V40V		NM_024787.2	NP_079063.2	Q9H9V4	RN122_HUMAN	ring finger protein 122	40						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding			endometrium(2)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		TGCCGAAGATGACCATATAGA	0.537000													19	78					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370810	35370810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35370810G>A	ENST00000373347.1	-	3	443	c.175C>T	c.(175-177)Cct>Tct	p.P59S	DLGAP3_ENST00000235180.4_Missense_Mutation_p.P59S|DLGAP3_ENST00000495979.1_5'UTR			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	59					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GGCCCTTCAGGAGAAATGTGT	0.711000													3	7					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99305460	99305460	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99305460G>A	ENST00000336374.2	-	12	1393	c.1391C>T	c.(1390-1392)tCc>tTc	p.S464F		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	464					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					AGGTTTGAAGGAGAAGTTCTG	0.348000													14	172					0	0	1	0	0
MIR518A1	574488	broad.mit.edu	37	19	54234287	54234287	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54234287C>T	ENST00000385068.1	+	0	28					NR_030210.1																						AAAGGGAAGCCCTTTCTGTTG	0.433000													48	141					0	0	1	0	0
DUSP12	11266	broad.mit.edu	37	1	161722918	161722918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161722918C>T	ENST00000367943.4	+	5	760	c.728C>T	c.(727-729)cCt>cTt	p.P243L	DUSP12_ENST00000484291.1_3'UTR	NM_007240.1	NP_009171.1	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	243					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|lung(1)	5	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			GGAAGTGGACCTATAGCCTTT	0.433000													56	136					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50683829	50683829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:50683829G>A	ENST00000442544.2	+	8	1981	c.1365G>A	c.(1363-1365)gcG>gcA	p.A455A	DCC_ENST00000412726.1_Silent_p.A303A|DCC_ENST00000581580.1_Silent_p.A110A	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	455	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTGCAGAAGCGAAAGGGAACA	0.502000													36	97					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87037411	87037411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87037411C>T	ENST00000265723.4	-	25	3332	c.3221G>A	c.(3220-3222)gGg>gAg	p.G1074E	ABCB4_ENST00000358400.3_Missense_Mutation_p.G1027E|ABCB4_ENST00000545634.1_Missense_Mutation_p.G1074E|ABCB4_ENST00000359206.3_Missense_Mutation_p.G1074E|ABCB4_ENST00000453593.1_Missense_Mutation_p.G1027E	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	1074	ABC transporter 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CGTGCTCTTCCCACAGCCACT	0.557000													25	118					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75203197	75203197	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:75203197G>A	ENST00000336926.6	-	8	640	c.614C>T	c.(613-615)tCc>tTc	p.S205F	HIP1_ENST00000434438.2_Missense_Mutation_p.S205F	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	205					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CATGTCCAGGGAGTTGAATAC	0.572000			T	PDGFRB	CMML								14	30					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81122553	81122553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:81122553G>A	ENST00000339711.4	+	9	1560	c.329G>A	c.(328-330)gGa>gAa	p.G110E	PRDM8_ENST00000504452.1_Missense_Mutation_p.G110E|PRDM8_ENST00000415738.2_Missense_Mutation_p.G110E	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	110	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						ATAAAAAACGGACAGCTGTTC	0.502000													17	58					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90349346	90349346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90349346C>T	ENST00000300060.6	-	2	782	c.469G>A	c.(469-471)Gag>Aag	p.E157K		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	157	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding	p.E157Q(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TCGGTGGGCTCCACCAGCTCA	0.617000													22	103					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27685247	27685247	+	Missense_Mutation	SNP	G	G	A	rs146598623		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27685247G>A	ENST00000493901.1	-	20	2775	c.2536C>T	c.(2536-2538)Cgc>Tgc	p.R846C	MAP3K6_ENST00000357582.2_Missense_Mutation_p.R846C|MAP3K6_ENST00000374040.3_Missense_Mutation_p.R838C	NM_004672.3	NP_004663.3	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	846	Protein kinase.				activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AAGGGGGGGCGACCTGTGGCC	0.617000													23	45					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728090	20728090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20728090G>A	ENST00000427401.4	-	4	1013	c.919C>T	c.(919-921)Cat>Tat	p.H307Y		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	307					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TCTCCGCTATGAATTATCTTA	0.408000													20	56					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90503026	90503026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90503026G>A	ENST00000325643.5	+	4	3690	c.3624G>A	c.(3622-3624)agG>agA	p.R1208R		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		AGGCCCACAGGAGGCCCAGAA	0.642000													6	10					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893670	36893670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36893670C>T	ENST00000301807.6	-	13	4831	c.2934G>A	c.(2932-2934)agG>agA	p.R978R	TRANK1_ENST00000429976.2_Silent_p.R1528R|TRANK1_ENST00000428977.2_Silent_p.R978R	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1528					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCTGAGTTTTCCTTTTATTCC	0.428000													21	48					0	0	1	0	0
FITM1	161247	broad.mit.edu	37	14	24601911	24601911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24601911C>T	ENST00000267426.5	+	2	1047	c.758C>T	c.(757-759)gCc>gTc	p.A253V	FITM1_ENST00000559294.1_Missense_Mutation_p.A57V	NM_203402.2	NP_981947.1	A5D6W6	FITM1_HUMAN	fat storage-inducing transmembrane protein 1	253					lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11						GTGGTGGGCGCCGCAGTGGGC	0.602000													30	68					0	0	1	0	0
SHE	126669	broad.mit.edu	37	1	154471640	154471640	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154471640G>A	ENST00000304760.2	-	2	752	c.666C>T	c.(664-666)gtC>gtT	p.V222V		NM_001010846.2	NP_001010846.1	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	222										breast(4)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	14	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CGTTCTCTCCGACTCTCTCTG	0.433000													30	74					0	0	1	0	0
TGM1	7051	broad.mit.edu	37	14	24730968	24730968	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24730968G>A	ENST00000206765.6	-	3	564	c.441C>T	c.(439-441)ttC>ttT	p.F147F	TGM1_ENST00000544573.1_Intron	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	147					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GGAGCATATGGAAAGGCTGCC	0.592000													13	127					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48312163	48312163	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48312163C>T	ENST00000435803.1	+	17	2924	c.2900C>T	c.(2899-2901)tCa>tTa	p.S967L		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	967					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ATTTATTCTTCATTTTACCGA	0.308000													27	51					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136536721	136536721	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136536721C>T	ENST00000371872.4	-	18	2519	c.2262G>A	c.(2260-2262)gcG>gcA	p.A754A	SARDH_ENST00000439388.1_Silent_p.A754A|SARDH_ENST00000371868.1_Silent_p.A182A|SARDH_ENST00000422262.2_Silent_p.A586A	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	754					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GCTTGGCACCCGCGGCCATCA	0.662000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179605338	179605338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179605338C>T	ENST00000589042.1	-	48	12846	c.12622G>A	c.(12622-12624)Gaa>Aaa	p.E4208K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E3845K|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E4037K|TTN_ENST00000359218.5_Missense_Mutation_p.E3970K|TTN_ENST00000591111.1_Missense_Mutation_p.E3891K|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3891							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTCAGGTTCAGCTAATAAA	0.388000													30	76					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47945211	47945211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47945211C>T	ENST00000402813.3	-	7	785	c.643G>A	c.(643-645)Gat>Aat	p.D215N	CNGA1_ENST00000358519.4_Missense_Mutation_p.D146N|CNGA1_ENST00000514170.1_Missense_Mutation_p.D146N|CNGA1_ENST00000420489.2_Missense_Mutation_p.D146N|CNGA1_ENST00000544810.1_Missense_Mutation_p.D146N			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	146					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						TCtttcttatctttgcttttc	0.328000													12	37					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210595030	210595030	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:210595030C>A	ENST00000360351.4	+	15	5899	c.5393C>A	c.(5392-5394)tCc>tAc	p.S1798Y	MAP2_ENST00000447185.1_Missense_Mutation_p.S1794Y|MAP2_ENST00000199940.6_Missense_Mutation_p.S530Y|MAP2_ENST00000361559.4_Missense_Mutation_p.S442Y|MAP2_ENST00000392194.1_Missense_Mutation_p.S442Y	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1798					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGCAATGTCTCCTCGTCTGGA	0.547000													11	49					0.00829132	0.00829502	1	1	0
TPCN1	53373	broad.mit.edu	37	12	113704138	113704138	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113704138C>T	ENST00000550785.1	+	5	776	c.607C>T	c.(607-609)Ccc>Tcc	p.P203S	TPCN1_ENST00000541517.1_Missense_Mutation_p.P203S|TPCN1_ENST00000335509.6_Missense_Mutation_p.P131S|TPCN1_ENST00000392569.4_Missense_Mutation_p.P63S	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	131						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						CCCCGCCGTCCCCGCACTCCG	0.632000													127	255					0	0	1	0	0
PLGLA	285189	broad.mit.edu	37	2	107002817	107002817	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107002817G>A	ENST00000484422.1	+	0	49																											CTGGGGGCAGGAAGCAGAGAA	0.483000													96	231					0	0	1	0	0
AKT1	207	broad.mit.edu	37	14	105239822	105239822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105239822C>T	ENST00000554581.1	-	8	2278	c.798G>A	c.(796-798)tcG>tcA	p.S266S	AKT1_ENST00000544168.1_Silent_p.S204S|AKT1_ENST00000349310.3_Silent_p.S266S|AKT1_ENST00000402615.2_Silent_p.S266S|AKT1_ENST00000554848.1_Silent_p.S266S|AKT1_ENST00000554192.1_5'UTR|AKT1_ENST00000407796.2_Silent_p.S266S|AKT1_ENST00000555528.1_Silent_p.S266S			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	266	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	CGTTCTTCTCCGAGTGCAGGT	0.672000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								4	32					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56196429	56196429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56196429C>T	ENST00000361673.3	-	6	5608	c.5395G>A	c.(5395-5397)Gaa>Aaa	p.E1799K		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1799	Ig-like 2.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CCAGAGTGTTCAGGGAACATC	0.368000													16	108					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72538358	72538358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72538358G>A	ENST00000299290.1	-	6	851	c.462C>T	c.(460-462)tcC>tcT	p.S154S	TBATA_ENST00000545575.1_Silent_p.S143S|TBATA_ENST00000456372.2_Silent_p.S154S	NM_152710.2	NP_689923.2			thymus, brain and testes associated																		AGGCCACCCGGGAAGCTAGCT	0.587000													59	151					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208224719	208224719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:208224719G>A	ENST00000367033.3	-	16	3800	c.3043C>T	c.(3043-3045)Ctt>Ttt	p.L1015F		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	1015	IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ACCGGGCCAAGGCCATTGGAT	0.562000													13	37					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13766107	13766107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13766107C>T	ENST00000265104.4	-	59	10183	c.10079G>A	c.(10078-10080)gGg>gAg	p.G3360E	DNAH5_ENST00000504001.3_Intron	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3360	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TAAAAAGTTCCCTGCAGTCAT	0.428000									Kartagener syndrome				23	142					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817564	4817564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4817564G>A	ENST00000248244.5	-	2	1055	c.826C>T	c.(826-828)Ccc>Tcc	p.P276S		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	276	Pro-rich.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GCCACTTCGGGAAGCCCAGGA	0.662000													16	28					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4933850	4933850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4933850C>T	ENST00000345988.2	-	22	4895	c.4806G>A	c.(4804-4806)gcG>gcA	p.A1602A	PPL_ENST00000590782.2_Silent_p.A1600A	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1602					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TCCCAGAGTCCGCCACGGTCA	0.577000													29	56					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369660	56369660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56369660G>A	ENST00000301295.6	+	3	1323	c.901G>A	c.(901-903)Gga>Aga	p.G301R	NLRP4_ENST00000346986.5_Missense_Mutation_p.G301R|NLRP4_ENST00000587891.1_Missense_Mutation_p.G226R	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	301	NACHT.						ATP binding	p.G301R(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCAGCCCCGGGGATTCAACGA	0.512000													21	66					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372173	126372173	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126372173C>T	ENST00000394329.3	+	9	10015	c.10002C>T	c.(10000-10002)caC>caT	p.H3334H	FAT4_ENST00000335110.5_Silent_p.H1632H	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3334	Cadherin 32.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGGAGGTACACTATTTGATTT	0.378000													28	142					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15636352	15636352	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15636352C>T	ENST00000269703.2	+	3	404	c.205C>T	c.(205-207)Ctg>Ttg	p.L69L	CYP4F22_ENST00000601005.2_Silent_p.L69L	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	69						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						CAACTGGCTGCTGGGCCACCT	0.672000													17	37					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	120980043	120980043	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120980043C>T	ENST00000392793.1	+	4	593	c.322C>T	c.(322-324)Cga>Tga	p.R108*	TECTA_ENST00000264037.2_Nonsense_Mutation_p.R108*			O75443	TECTA_HUMAN	tectorin alpha	108	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CAATGGAATTCGAGGCGAGAT	0.507000													24	46					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1418203	1418203	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1418203C>T	ENST00000345913.4	+	2	114	c.23C>T	c.(22-24)tCt>tTt	p.S8F	TPO_ENST00000382269.3_Missense_Mutation_p.S8F|TPO_ENST00000349624.3_Missense_Mutation_p.S8F|TPO_ENST00000329066.4_Missense_Mutation_p.S8F|TPO_ENST00000337415.3_Missense_Mutation_p.S8F|TPO_ENST00000539820.1_Missense_Mutation_p.S8F|TPO_ENST00000497517.2_Intron|TPO_ENST00000346956.3_Missense_Mutation_p.S8F|TPO_ENST00000382198.1_Missense_Mutation_p.S8F|TPO_ENST00000382201.3_Missense_Mutation_p.S8F	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	8					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCTGTGCTGTCTGTCACGCTG	0.507000													13	28					0	0	1	0	0
GBP1P1	400759	broad.mit.edu	37	1	89889957	89889957	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89889957G>A	ENST00000513638.1	+	0	698					NR_003133.2																						GATGGAGAGCGACAGGGTCCA	0.443000													99	354					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200957929	200957929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200957929G>A	ENST00000332129.2	-	22	3579	c.3263C>T	c.(3262-3264)cCc>cTc	p.P1088L	KIF21B_ENST00000461742.2_Missense_Mutation_p.P1088L|KIF21B_ENST00000360529.5_Missense_Mutation_p.P1088L|KIF21B_ENST00000422435.2_Missense_Mutation_p.P1088L	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	1088					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CTGCAGCTCGGGGTGAGCTTC	0.627000													13	30					0	0	1	0	0
ZNF486	90649	broad.mit.edu	37	19	20278139	20278139	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20278139G>A	ENST00000335117.8	+	0	57				CTC-260E6.6_ENST00000593655.1_RNA|ZNF486_ENST00000597083.1_De_novo_Start_InFrame|CTC-260E6.6_ENST00000586657.1_RNA	NM_052852.3	NP_443084.2	Q96H40	ZN486_HUMAN	zinc finger protein 486						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11						CCACAGCCAAGATGCCGGGAC	0.582000													13	77					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240341341	240341341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240341341G>A	ENST00000319653.9	+	3	2133	c.1903G>A	c.(1903-1905)Gaa>Aaa	p.E635K	RP11-567G24.3_ENST00000412311.1_RNA|RP11-567G24.3_ENST00000444308.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	635					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCCCGATGAGGAACACAGGCT	0.473000													19	62					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6977581	6977581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6977581G>A	ENST00000278319.5	+	7	1961	c.1373G>A	c.(1372-1374)gGa>gAa	p.G458E	ZNF215_ENST00000414517.2_Missense_Mutation_p.G458E|ZNF215_ENST00000529903.1_Intron	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	458					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CTCCATTTTGGAAACAATTTC	0.393000													19	70					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170096247	170096247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170096247G>A	ENST00000263816.3	-	26	4369	c.4084C>T	c.(4084-4086)Cac>Tac	p.H1362Y		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1362	EGF-like 5.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACACACTCGTGAGTACAACCA	0.383000													26	69					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283247	152283247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152283247C>T	ENST00000368799.1	-	3	4150	c.4115G>A	c.(4114-4116)gGc>gAc	p.G1372D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1372	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGCCCAATGCCTGAGTGTCT	0.537000									Ichthyosis				213	560					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140720094	140720094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140720094C>T	ENST00000394576.2	+	1	1556	c.1556C>T	c.(1555-1557)tCc>tTc	p.S519F	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACTGCGCTCCTTTGATTAT	0.507000													68	117					0	0	1	0	0
TBXA2R	6915	broad.mit.edu	37	19	3600303	3600303	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3600303G>A	ENST00000375190.4	-	2	723	c.330C>T	c.(328-330)gtC>gtT	p.V110V	TBXA2R_ENST00000411851.3_Silent_p.V110V|TBXA2R_ENST00000589966.1_Silent_p.V110V	NM_001060.5|NM_201636.2	NP_001051.1|NP_963998.2	P21731	TA2R_HUMAN	thromboxane A2 receptor	110					platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	AGATCATGACGACGCCCATGA	0.692000													19	37					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112358338	112358338	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112358338G>A	ENST00000206423.3	-	2	1368	c.415C>T	c.(415-417)Ccc>Tcc	p.P139S	CCDC80_ENST00000439685.2_Missense_Mutation_p.P139S|CCDC80_ENST00000475181.1_5'UTR	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	139										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						AGGATGTTGGGAGAGCTGGAC	0.572000													8	127					0	0	1	0	0
ASCL1	429	broad.mit.edu	37	12	103352675	103352675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:103352675C>T	ENST00000266744.3	+	1	1212	c.653C>T	c.(652-654)tCt>tTt	p.S218F		NM_004316.3	NP_004307.2	P50553	ASCL1_HUMAN	achaete-scute family bHLH transcription factor 1	218					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			NS(3)|large_intestine(1)|lung(1)	5						GACGAGGGCTCTTACGACCCG	0.632000													14	41					0	0	1	0	0
BANF2	140836	broad.mit.edu	37	20	17705763	17705763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:17705763C>T	ENST00000246090.5	+	3	355	c.93C>T	c.(91-93)ctC>ctT	p.L31L	BANF2_ENST00000377805.3_Silent_p.L31L|BANF2_ENST00000545418.2_Silent_p.L38L	NM_178477.4	NP_848572.3	Q9H503	BAFL_HUMAN	barrier to autointegration factor 2	31						cytoplasm|nucleus	DNA binding			large_intestine(1)|lung(1)|prostate(3)|skin(1)	6						GCCATGAGCTCGCGATCAATT	0.493000													19	88					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241555917	241555917	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241555917C>T	ENST00000270364.7	+	3	526	c.386C>T	c.(385-387)tCa>tTa	p.S129L	GPR35_ENST00000438013.2_5'UTR|GPR35_ENST00000319838.5_5'UTR|GPR35_ENST00000403859.1_5'UTR			Q9HC96	CAN10_HUMAN	calpain 10	0	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		tccgatacttcaccagattca	0.522000													141	266					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10645331	10645331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10645331C>T	ENST00000547195.1	-	9	1668	c.1168G>A	c.(1168-1170)Gaa>Aaa	p.E390K	MRVI1_ENST00000531107.1_Missense_Mutation_p.E473K|MRVI1_ENST00000552103.1_Missense_Mutation_p.E390K|MRVI1_ENST00000421747.1_Missense_Mutation_p.E472K|MRVI1_ENST00000558540.1_Missense_Mutation_p.E166K|MRVI1_ENST00000527509.2_Missense_Mutation_p.E390K|MRVI1_ENST00000545852.1_Missense_Mutation_p.E166K|MRVI1_ENST00000436272.1_Missense_Mutation_p.E454K|MRVI1_ENST00000541483.1_Missense_Mutation_p.E275K|MRVI1_ENST00000423302.2_Missense_Mutation_p.E481K|MRVI1_ENST00000424001.1_Missense_Mutation_p.E166K|MRVI1_ENST00000534266.2_Missense_Mutation_p.E166K	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	454					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTACCTTTTTCCTGCTCAGCT	0.468000													19	72					0	0	1	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389971	150389971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150389971G>A	ENST00000223293.5	+	3	691	c.597G>A	c.(595-597)atG>atA	p.M199I		NM_015660.2	NP_056475.1	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	199						integral to membrane	GTP binding			kidney(1)|large_intestine(1)|lung(8)|skin(2)|urinary_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGAACTAATGGACTGTATTG	0.468000													34	159					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450252	105450252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105450252C>T	ENST00000337685.2	+	5	1612	c.827C>T	c.(826-828)tCa>tTa	p.S276L	MUM1L1_ENST00000372552.1_Missense_Mutation_p.S276L|MUM1L1_ENST00000357175.2_Missense_Mutation_p.S276L	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	276										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						TCTGCTTTCTCAGAGAATATT	0.488000													9	11					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215876180	215876180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215876180C>T	ENST00000272895.7	-	17	2534	c.2315G>A	c.(2314-2316)gGa>gAa	p.G772E	ABCA12_ENST00000389661.4_Missense_Mutation_p.G454E	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	772					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity	p.G772E(1)		NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TATGGGAATTCCATATTTTGA	0.343000													17	39					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105963467	105963467	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105963467G>A	ENST00000357060.3	-	8	1173	c.1058C>T	c.(1057-1059)tCt>tTt	p.S353F	WDR96_ENST00000428666.1_Missense_Mutation_p.S354F|WDR96_ENST00000278064.2_Missense_Mutation_p.S284F|WDR96_ENST00000369719.1_Missense_Mutation_p.S284F|WDR96_ENST00000369720.1_Missense_Mutation_p.S284F	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	353										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						ATAATTGGGAGAAAATGTCAT	0.313000													29	57					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10384494	10384494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10384494C>T	ENST00000397077.1	-	18	3299	c.2724G>A	c.(2722-2724)aaG>aaA	p.K908K	ATP2B2_ENST00000352432.4_Silent_p.K953K|ATP2B2_ENST00000343816.4_Silent_p.K939K|ATP2B2_ENST00000383800.4_Silent_p.K908K|ATP2B2_ENST00000360273.2_Silent_p.K953K			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	953					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CCAGGATGTTCTTCATCATGG	0.632000													6	53					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27157868	27157868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27157868C>T	ENST00000380036.4	+	2	534	c.92C>T	c.(91-93)tCc>tTc	p.S31F	TEK_ENST00000519097.1_Intron|TEK_ENST00000406359.4_Missense_Mutation_p.S31F	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	31					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TTGATCAATTCCCTACCTCTT	0.458000													78	168					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64644097	64644097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:64644097C>T	ENST00000371079.1	+	9	2748	c.2373C>T	c.(2371-2373)ttC>ttT	p.F791F	ROR1_ENST00000545203.1_Silent_p.F242F	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	791	Pro-rich.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						ATTACATGTTCCCGAGCCAGG	0.507000													26	96					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100686795	100686795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100686795C>T	ENST00000306151.4	+	3	12162	c.12098C>T	c.(12097-12099)aCa>aTa	p.T4033I		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4033						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GCAACCAGTACACCTCACACC	0.527000													60	174					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72233977	72233977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:72233977G>A	ENST00000340726.3	-	6	1049	c.410C>T	c.(409-411)tCc>tTc	p.S137F	EYA1_ENST00000303824.7_Missense_Mutation_p.S136F|EYA1_ENST00000388742.4_Missense_Mutation_p.S137F|EYA1_ENST00000388741.2_Missense_Mutation_p.S103F|EYA1_ENST00000388743.2_Missense_Mutation_p.S136F|EYA1_ENST00000388740.3_Missense_Mutation_p.S104F|EYA1_ENST00000419131.1_Missense_Mutation_p.S137F	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	137					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ACCATATGAGGAAATGCCGTA	0.488000													14	34					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249533	52249533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52249533G>A	ENST00000595042.1	-	3	856	c.715C>T	c.(715-717)Ccc>Tcc	p.P239S	FPR1_ENST00000304748.4_Missense_Mutation_p.P239S	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	239					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	ACCCGTAAGGGACGACTGGAC	0.507000													19	48					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873950	36873950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36873950C>T	ENST00000301807.6	-	21	7239	c.5342G>A	c.(5341-5343)gGg>gAg	p.G1781E	TRANK1_ENST00000429976.2_Missense_Mutation_p.G2331E|TRANK1_ENST00000428977.2_Missense_Mutation_p.G1781E	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2331					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCTGCCTCTCCCCCTGCCCCT	0.502000													52	111					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1574994	1574994	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1574994C>T	ENST00000421627.2	+	4	1425	c.1291C>T	c.(1291-1293)Cgg>Tgg	p.R431W		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	510					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ATTCCGCTCCCGGAACCAGAG	0.627000													5	9					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31155072	31155072	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31155072C>T	ENST00000268281.4	-	7	865	c.807G>A	c.(805-807)cgG>cgA	p.R269R	PRSS36_ENST00000569305.1_Silent_p.R269R|PRSS36_ENST00000418068.2_Silent_p.R269R	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	269	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						GGCGGTTTCTCCGTCCACAGC	0.612000													16	53					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622450	74622450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74622450C>T	ENST00000156626.7	-	6	1535	c.1336G>A	c.(1336-1338)Gaa>Aaa	p.E446K		NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	446					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						CGGGTGCCTTCCAGGAAGTGC	0.557000													22	54					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106066502	106066502	+	RNA	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106066502T>C	ENST00000577108.1	-	0	44				IGHE_ENST00000576077.1_RNA																							TCTGCTCCCATTCGGCCCTGG	0.627000													7	121					0	0	1	0	0
SFXN1	94081	broad.mit.edu	37	5	174940517	174940517	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:174940517G>A	ENST00000321442.5	+	7	902	c.648G>A	c.(646-648)ggG>ggA	p.G216G		NM_022754.5	NP_073591.2	Q9H9B4	SFXN1_HUMAN	sideroflexin 1	216					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity|protein binding			endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|skin(3)	15	all_cancers(89;0.00922)|Renal(175;0.000269)|Lung NSC(126;0.00515)|all_lung(126;0.00873)	Medulloblastoma(196;0.0399)|all_neural(177;0.0663)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ACCGCTTGGGGGAGTCGGCGA	0.517000													28	57					0	0	1	0	0
MTHFD2	10797	broad.mit.edu	37	2	74438352	74438352	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74438352C>T	ENST00000394053.2	+	6	777	c.697C>T	c.(697-699)Cga>Tga	p.R233*	MTHFD2_ENST00000394050.3_Nonsense_Mutation_p.R69*|MTHFD2_ENST00000264090.4_Nonsense_Mutation_p.R131*|MTHFD2_ENST00000409804.1_Nonsense_Mutation_p.R105*|MTHFD2_ENST00000409601.1_Nonsense_Mutation_p.R192*	NM_006636.3	NP_006627.2	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	233					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	AATATCTCATCGATATACTCC	0.398000													39	127					0	0	1	0	0
CCDC134	79879	broad.mit.edu	37	22	42204930	42204930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42204930C>T	ENST00000255784.5	+	2	140	c.36C>T	c.(34-36)gtC>gtT	p.V12V	CCDC134_ENST00000402061.3_Silent_p.V12V	NM_024821.2	NP_079097.1	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134	12						extracellular region				large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						TCCTCTTTGTCCTGCTTTTGT	0.493000													19	92					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52520434	52520434	+	Missense_Mutation	SNP	G	G	A	rs142884639	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52520434G>A	ENST00000216286.5	-	5	1291	c.1292C>T	c.(1291-1293)tCg>tTg	p.S431L	NID2_ENST00000541773.1_Missense_Mutation_p.S378L	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	431						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					ATCCATTTCCGAAGGCACTGG	0.537000													41	86					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240493995	240493995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240493995G>A	ENST00000319653.9	+	11	4760	c.4530G>A	c.(4528-4530)caG>caA	p.Q1510Q	FMN2_ENST00000545751.1_Silent_p.Q106Q	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1510	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCGAGGACAGGCAGATGGCT	0.423000													19	101					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127646621	127646621	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127646621G>A	ENST00000405109.1	+	3	1552	c.1085G>A	c.(1084-1086)gGa>gAa	p.G362E	KBTBD12_ENST00000407609.3_5'UTR|KBTBD12_ENST00000343941.4_Missense_Mutation_p.E4K|KBTBD12_ENST00000405256.1_Missense_Mutation_p.G362E|KBTBD12_ENST00000492025.1_Intron			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	362										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						CATGATAGAGGAAACCAGTTT	0.368000													65	179					0	0	1	0	0
TNFSF9	8744	broad.mit.edu	37	19	6534669	6534669	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6534669C>T	ENST00000245817.3	+	3	395	c.357C>T	c.(355-357)tcC>tcT	p.S119S		NM_003811.3	NP_003802.1	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily, member 9	119					apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						CAGGCGTGTCCCTGACGGGGG	0.592000													5	13					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857960	9857960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9857960G>A	ENST00000396573.2	-	14	3750	c.3441C>T	c.(3439-3441)ttC>ttT	p.F1147F	GRIN2A_ENST00000404927.2_Silent_p.F1147F|GRIN2A_ENST00000562109.1_Silent_p.F1147F|GRIN2A_ENST00000330684.3_Silent_p.F1147F|GRIN2A_ENST00000396575.2_Silent_p.F1147F|GRIN2A_ENST00000535259.1_Silent_p.F990F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1147					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGGGTCCGGGAAGTCCACGT	0.527000													32	112					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4836859	4836859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4836859G>A	ENST00000354582.6	+	52	7224	c.6874G>A	c.(6874-6876)Gga>Aga	p.G2292R	ITPR1_ENST00000302640.8_Missense_Mutation_p.G2292R|ITPR1_ENST00000456211.2_Missense_Mutation_p.G2244R|ITPR1_ENST00000423119.2_Missense_Mutation_p.G2259R|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.G2259R|ITPR1_ENST00000443694.2_Missense_Mutation_p.G2292R			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2307					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CCCGTTTAAGGGAGTCCGAGG	0.483000													10	28					0	0	1	0	0
CHIAP2	149620	broad.mit.edu	37	1	111826767	111826767	+	RNA	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111826767T>G	ENST00000369743.4	+	0	1477					NR_003928.1																						TGGACACTCCTTCCTTCTGAG	0.547000													10	23					0	0	1	0	0
CACNG2	10369	broad.mit.edu	37	22	36983516	36983516	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36983516G>A	ENST00000300105.6	-	2	1272	c.291C>T	c.(289-291)ttC>ttT	p.F97F		NM_006078.3	NP_006069.1	Q9Y698	CCG2_HUMAN	calcium channel, voltage-dependent, gamma subunit 2	97					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	18						ACTCACGGAGGAAATATTCTG	0.512000													41	94					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205197796	205197796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205197796C>T	ENST00000358024.3	+	1	493	c.104C>T	c.(103-105)cCt>cTt	p.P35L		NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	35						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GACCTCCGGCCTGGGGAGACC	0.672000													17	26					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34775646	34775646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34775646G>A	ENST00000338074.2	+	8	995	c.834G>A	c.(832-834)aaG>aaA	p.K278K	EPB41L1_ENST00000202028.5_Silent_p.K216K|EPB41L1_ENST00000373941.1_Silent_p.K278K|EPB41L1_ENST00000441639.1_Silent_p.K216K|EPB41L1_ENST00000373946.3_Silent_p.K247K|EPB41L1_ENST00000373950.2_Silent_p.K181K	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	278	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					AGAATGCCAAGAAGCTTTCCA	0.537000													12	35					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102056928	102056928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102056928G>A	ENST00000318222.3	-	6	1376	c.994C>T	c.(994-996)Cca>Tca	p.P332S	PKD2L1_ENST00000338519.3_Missense_Mutation_p.P257S|PKD2L1_ENST00000353274.3_Missense_Mutation_p.P332S	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	332					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TGCCAGGATGGGATGGCACCT	0.562000													23	76					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43858486	43858486	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43858486G>A	ENST00000378009.4	+	0	363				CD177_ENST00000607517.1_RNA|CD177_ENST00000378012.2_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				GCCGCCAGGAGGACTTCTGCA	0.677000													27	64					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51753026	51753026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51753026C>T	ENST00000543196.2	-	7	1463	c.1258G>A	c.(1258-1260)Ggc>Agc	p.G420S	GALNT6_ENST00000356317.3_Missense_Mutation_p.G420S			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	420					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						ACACTAGTGCCCTTGGGGAAG	0.547000													87	221					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34513176	34513176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34513176G>A	ENST00000242317.4	+	16	1727	c.1556G>A	c.(1555-1557)gGa>gAa	p.G519E		NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	519					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		ACAGAGGAGGGAAAAATCTAC	0.522000									Kartagener syndrome				62	105					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51413243	51413243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51413243C>T	ENST00000266037.9	+	51	5500	c.5477C>T	c.(5476-5478)cCc>cTc	p.P1826L		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1826						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGCAGTGATCCCAATCTGTCT	0.532000													38	92					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102445	168102445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168102445G>A	ENST00000409195.1	+	9	4632	c.4543G>A	c.(4543-4545)Gaa>Aaa	p.E1515K	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E1515K|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E1293K	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1340					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AATGACCAAGGAAGAAATCCC	0.358000													50	100					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42940083	42940083	+	Silent	SNP	G	G	A	rs146924589	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42940083G>A	ENST00000426333.2	-	16	1902	c.1605C>T	c.(1603-1605)gcC>gcT	p.A535A	EFTUD2_ENST00000402521.3_Silent_p.A500A|EFTUD2_ENST00000592576.1_Silent_p.A525A|EFTUD2_ENST00000591382.1_Silent_p.A535A	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	535						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				GGCAGTACCTGGCCACAGAGA	0.582000													7	10					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117884974	117884974	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:117884974G>A	ENST00000439649.3	-	5	880	c.513C>T	c.(511-513)acC>acT	p.T171T	GFRA1_ENST00000369236.1_Silent_p.T171T|GFRA1_ENST00000544592.1_Silent_p.T55T|GFRA1_ENST00000355422.6_Silent_p.T176T	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	176					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		TGGTGCACGGGGTGATGTACG	0.587000													4	40					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38939413	38939413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38939413G>A	ENST00000359357.3	+	81	12100	c.11846G>A	c.(11845-11847)cGa>cAa	p.R3949Q	DNAH8_ENST00000449981.2_Missense_Mutation_p.R4166Q|DNAH8_ENST00000441566.1_Missense_Mutation_p.R3913Q					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTACATGCTCGAAAGCTGATT	0.413000													22	94					0	0	1	0	0
PLIN3	10226	broad.mit.edu	37	19	4847814	4847814	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4847814G>A	ENST00000221957.4	-	6	899	c.723C>T	c.(721-723)tcC>tcT	p.S241S	PLIN3_ENST00000592528.1_Silent_p.S229S|PLIN3_ENST00000585479.1_Silent_p.S241S	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	241					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	TCTCCGACAGGGAGCCCAGAC	0.637000													10	32					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42482807	42482807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42482807G>A	ENST00000545399.1	-	12	1773	c.1620C>T	c.(1618-1620)gcC>gcT	p.A540A	ATP1A3_ENST00000602133.1_Silent_p.A497A|ATP1A3_ENST00000543770.1_Silent_p.A538A|ATP1A3_ENST00000302102.5_Silent_p.A527A	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	527					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						CATTCTGGAAGGCCTCCTTCA	0.662000													20	81					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38904723	38904723	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38904723C>A	ENST00000302328.3	-	24	4217	c.4019G>T	c.(4018-4020)gGa>gTa	p.G1340V	SCN11A_ENST00000456224.3_Missense_Mutation_p.G1302V|SCN11A_ENST00000444237.2_Missense_Mutation_p.G1340V|SCN11A_ENST00000450244.1_Missense_Mutation_p.G1340V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1340					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTTTTTGGATCCTAATTTTTT	0.348000													18	47					1.67942e-08	1.6852e-08	1	1	0
NRK	203447	broad.mit.edu	37	X	105152872	105152872	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105152872C>T	ENST00000428173.2	+	13	1545	c.1242C>T	c.(1240-1242)gcC>gcT	p.A414A	NRK_ENST00000243300.9_Silent_p.A413A			Q7Z2Y5	NRK_HUMAN	Nik related kinase	413	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						AGGGAGCAGCCAGGGTATTCA	0.587000										HNSCC(51;0.14)			16	14					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718688	140718688	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140718688G>A	ENST00000394576.2	+	1	150	c.150G>A	c.(148-150)aaG>aaA	p.K50K	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACATCGCCAAGGACTTGGGTT	0.617000											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	94					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205890756	205890756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205890756G>A	ENST00000367135.3	-	17	2106	c.1993C>T	c.(1993-1995)Ctc>Ttc	p.L665F	SLC26A9_ENST00000367134.2_Missense_Mutation_p.L665F|SLC26A9_ENST00000340781.4_Missense_Mutation_p.L665F	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	665	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			TCCAGGATGAGGGTGTGGAAG	0.647000													5	19					0	0	1	0	0
C14orf119	55017	broad.mit.edu	37	14	23566952	23566952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23566952C>T	ENST00000319074.4	+	2	941	c.85C>T	c.(85-87)Cct>Tct	p.P29S	C14orf119_ENST00000554203.1_Missense_Mutation_p.P29S	NM_017924.3	NP_060394.1	Q9NWQ9	CN119_HUMAN	chromosome 14 open reading frame 119	29										central_nervous_system(1)|endometrium(1)|lung(1)	3	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00649)		CCCTTCCCCTCCTCTGATGTC	0.488000													82	201					0	0	1	0	0
LOC101929950	101929950	broad.mit.edu	37	17	36375119	36375119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:36375119G>A	ENST00000312412.4	-	3	398	c.399C>T	c.(397-399)ttC>ttT	p.F133F	RP11-1407O15.2_ENST00000544906.1_5'UTR																kidney(1)|lung(3)	4						GAGTACTAGGGAAAGACAAGG	0.348000													6	42					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71511997	71511997	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:71511997C>T	ENST00000304743.2	+	20	4461	c.4015C>T	c.(4015-4017)Cga>Tga	p.R1339*	PCNX_ENST00000238570.5_Nonsense_Mutation_p.R1339*|PCNX_ENST00000439984.3_Nonsense_Mutation_p.R1228*	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1339						integral to membrane		p.R1339*(1)		NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GTATGAAGTTCGAAGTAAGTA	0.343000													24	59					0	0	1	0	0
CCDC83	220047	broad.mit.edu	37	11	85627240	85627240	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:85627240G>A	ENST00000280245.4	+	11	1649	c.1137G>A	c.(1135-1137)atG>atA	p.M379I	CCDC83_ENST00000376067.1_Missense_Mutation_p.M248I|CCDC83_ENST00000342404.3_Missense_Mutation_p.M348I	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	348										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				ACACTGATATGAAGTACTTAC	0.348000													63	112					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105105720	105105720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:105105720C>T	ENST00000436393.2	+	21	2984	c.2743C>T	c.(2743-2745)Cat>Tat	p.H915Y	RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000507740.1_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	369					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATGGGATCCTCATAGAGGGGC	0.398000										HNSCC(12;0.0054)			41	98					0	0	1	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026534	176026534	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176026534G>A	ENST00000303991.4	-	2	479	c.302C>T	c.(301-303)cCc>cTc	p.P101L		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	101						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGACTCCTGGGGAGAGAAGCA	0.647000													22	50					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105252524	105252524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:105252524C>T	ENST00000306107.5	+	5	1037	c.537C>T	c.(535-537)ccC>ccT	p.P179P	ALCAM_ENST00000389927.4_5'UTR|ALCAM_ENST00000486979.2_Silent_p.P128P|ALCAM_ENST00000481337.1_3'UTR|ALCAM_ENST00000472644.2_Silent_p.P179P	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	179	Ig-like V-type 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						TGCTACATCCCCTTGAAGGAG	0.448000													29	90					0	0	1	0	0
APOBEC3F	200316	broad.mit.edu	37	22	39448345	39448345	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39448345C>T	ENST00000308521.5	+	6	1347	c.990C>T	c.(988-990)atC>atT	p.I330I	APOBEC3G_ENST00000452957.2_Intron	NM_145298.5	NP_660341.2	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F	337					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|skin(2)	16	Melanoma(58;0.04)					CCGTGGAGATCATGGGCTACA	0.617000													36	81					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716045	13716045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13716045G>A	ENST00000279593.3	-	13	4336	c.4127C>T	c.(4126-4128)tCg>tTg	p.S1376L		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1376					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGGTAGAGCGACTTGCTGAG	0.587000													11	31					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207644806	207644806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207644806G>A	ENST00000367057.3	+	9	1721	c.1532G>A	c.(1531-1533)gGc>gAc	p.G511D	CR2_ENST00000367059.3_Missense_Mutation_p.G511D|CR2_ENST00000458541.2_Intron|CR2_ENST00000367058.3_Missense_Mutation_p.G511D	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	511	Sushi 8.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						GAGTGTCAAGGCACAATTCCT	0.403000													55	147					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143093026	143093026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:143093026G>A	ENST00000367603.2	-	5	3592	c.2850C>T	c.(2848-2850)tcC>tcT	p.S950S	HIVEP2_ENST00000012134.2_Silent_p.S950S|HIVEP2_ENST00000367604.1_Silent_p.S950S	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	950	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ACTCCCCTGAGGAGTGCTCCA	0.557000													34	52					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	124007847	124007847	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124007847C>T	ENST00000456829.2	+	15	2002	c.1751C>T	c.(1750-1752)tCc>tTc	p.S584F	VWA5A_ENST00000360334.4_Intron|VWA5A_ENST00000392748.1_Missense_Mutation_p.S584F	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	584										autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						GTCATAAGCTCCTTCACAGCT	0.502000													17	60					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110232227	110232227	+	Silent	SNP	G	G	A	rs146929022		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110232227G>A	ENST00000418703.2	-	7	1492	c.1398C>T	c.(1396-1398)ttC>ttT	p.F466F	TRPV4_ENST00000544971.1_Silent_p.F359F|TRPV4_ENST00000536838.1_Silent_p.F432F|TRPV4_ENST00000346520.2_Silent_p.F406F|TRPV4_ENST00000537083.1_Silent_p.F406F|TRPV4_ENST00000261740.2_Silent_p.F466F|TRPV4_ENST00000392719.2_Silent_p.F419F|TRPV4_ENST00000541794.1_Silent_p.F419F	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	466					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						AGACGGCCCCGAACTTGCGCC	0.602000													48	108					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66101939	66101939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:66101939G>A	ENST00000349533.6	+	20	2924	c.2739G>A	c.(2737-2739)ttG>ttA	p.L913L	LEPR_ENST00000406510.3_5'UTR	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	913					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CTCTTCTTTTGGAGCCTGAAA	0.368000													68	198					0	0	1	0	0
CIB4	130106	broad.mit.edu	37	2	26806663	26806663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26806663C>T	ENST00000288861.4	-	5	485	c.432G>A	c.(430-432)acG>acA	p.T144T	CIB4_ENST00000405346.3_5'UTR	NM_001029881.1	NP_001025052.1	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	144	EF-hand 3.						calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACACGTGGTTCGTGAGGTCCA	0.582000													15	76					0	0	1	0	0
PPP6R1	22870	broad.mit.edu	37	19	55757032	55757032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55757032G>A	ENST00000412770.2	-	3	808	c.242C>T	c.(241-243)gCc>gTc	p.A81V	PPP6R1_ENST00000587283.1_Missense_Mutation_p.A81V	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	81	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						AATCTCGCAGGCCACACTGGG	0.667000													8	22					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74007901	74007901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74007901G>A	ENST00000301607.3	-	20	2773	c.2520C>T	c.(2518-2520)gcC>gcT	p.A840A	EVPL_ENST00000586740.1_Silent_p.A862A	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	840	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GTCTCTTGGGGGCTGACACTG	0.622000													12	30					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202914163	202914163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202914163G>A	ENST00000340990.5	-	5	863	c.565C>T	c.(565-567)Ctc>Ttc	p.L189F	ADIPOR1_ENST00000367254.3_Intron|ADIPOR1_ENST00000436244.1_Missense_Mutation_p.L189F	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	189					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			GTGTGAAAGAGCCAGGAGAAG	0.448000													13	158					0	0	1	0	0
TXK	7294	broad.mit.edu	37	4	48073536	48073536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48073536C>T	ENST00000264316.4	-	14	1598	c.1513G>A	c.(1513-1515)Gag>Aag	p.E505K	TXK_ENST00000507351.1_Missense_Mutation_p.E160K	NM_003328.2	NP_003319.2	P42681	TXK_HUMAN	TXK tyrosine kinase	505	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(2)	25						ATGCTTACCTCATGCCAGCAG	0.453000													56	98					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49425842	49425842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49425842G>A	ENST00000301067.7	-	39	12645	c.12646C>T	c.(12646-12648)Cct>Tct	p.P4216S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGCTGCTGAGGACTTAAGTGC	0.622000													7	62					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126132444	126132444	+	Missense_Mutation	SNP	G	G	A	rs139824767		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126132444G>A	ENST00000373631.3	+	7	1113	c.1112G>A	c.(1111-1113)gGa>gAa	p.G371E	CRB2_ENST00000359999.3_Missense_Mutation_p.G371E|CRB2_ENST00000373629.2_Missense_Mutation_p.G39E	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	371	EGF-like 8; calcium-binding (Potential).					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						CTGCACGGCGGAACCTGCAGT	0.602000													20	59					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57869041	57869041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57869041C>T	ENST00000391705.3	+	4	2088	c.1804C>T	c.(1804-1806)Ctc>Ttc	p.L602F	ZNF304_ENST00000443917.2_Missense_Mutation_p.L649F|ZNF304_ENST00000282286.5_Missense_Mutation_p.L602F|ZNF304_ENST00000598744.1_Missense_Mutation_p.L560F	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	602					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CAACTCTGGCCTCATTCTGCA	0.478000													32	68					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895665	90895665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:90895665C>T	ENST00000287934.2	+	1	1883	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	490					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding	p.F490F(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGCGTGGCTTCGTGCTGGCGC	0.612000													75	188					0	0	1	0	0
OR1L3	26735	broad.mit.edu	37	9	125437994	125437994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125437994G>A	ENST00000304820.2	+	1	680	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						CTTTGTCAATGAAATTGTGGC	0.433000													56	197					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21252800	21252800	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21252800C>T	ENST00000233242.1	-	11	1567	c.1440G>A	c.(1438-1440)ggG>ggA	p.G480G	APOB_ENST00000399256.4_Silent_p.G480G	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	480	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATCTTCATCCCCAGTGCAGT	0.418000													48	160					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72509738	72509738	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72509738C>T	ENST00000373208.1	+	16	2433	c.2433C>T	c.(2431-2433)atC>atT	p.I811I	ADAMTS14_ENST00000373207.1_Silent_p.I808I	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	808	Spacer.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						CCATTGCCATCCTGGTGAGCC	0.642000													11	56					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383994	108383994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108383994G>A	ENST00000265843.4	-	6	2350	c.2240C>T	c.(2239-2241)tCc>tTc	p.S747F	EXPH5_ENST00000428840.1_Missense_Mutation_p.S671F|EXPH5_ENST00000443411.1_Missense_Mutation_p.S559F|EXPH5_ENST00000525344.1_Missense_Mutation_p.S740F	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	747					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGAGTCCTGGGATAAGGGATT	0.423000													42	87					0	0	1	0	0
PLGLA	285189	broad.mit.edu	37	2	107002828	107002828	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107002828G>A	ENST00000484422.1	+	0	60																											AAGCAGAGAAGAATGTGCAGC	0.473000													66	276					0	0	1	0	0
REG3G	130120	broad.mit.edu	37	2	79253856	79253856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79253856G>A	ENST00000272324.5	+	3	278	c.94G>A	c.(94-96)Gaa>Aaa	p.E32K	REG3G_ENST00000393897.2_Missense_Mutation_p.E32K|REG3G_ENST00000409471.1_Missense_Mutation_p.E32K	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	32					acute-phase response	extracellular region	sugar binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AACCCAGAAGGAACTGCCCTC	0.532000													20	49					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032146	26032146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26032146G>A	ENST00000244661.2	-	1	142	c.143C>T	c.(142-144)gCt>gTt	p.A48V		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	48					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						CTCGCGCAGAGCCACAGTGCC	0.632000													35	148					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162505	33162505	+	RNA	SNP	C	C	T	rs146818486	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33162505C>T	ENST00000510327.1	-	0	346																											GTGTTGTACTCGTAAAACAAG	0.502000													20	56					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130319437	130319437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130319437C>T	ENST00000299164.2	+	1	569	c.569C>T	c.(568-570)cCt>cTt	p.P190L		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	190					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GCCCTGGACCCTTACAAGCCG	0.726000													5	5					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	122075601	122075601	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:122075601G>A	ENST00000265922.3	-	2	494	c.33C>T	c.(31-33)ttC>ttT	p.F11F	DBC1_ENST00000373964.2_Silent_p.F11F	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		11					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						ATATAAACAGGAAGTAGAGGA	0.473000													15	54					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168861618	168861618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168861618G>A	ENST00000264674.3	-	3	144	c.6C>T	c.(4-6)atC>atT	p.I2I	MECOM_ENST00000433243.2_5'UTR|MECOM_ENST00000392736.3_5'UTR|MECOM_ENST00000472280.1_5'UTR|MECOM_ENST00000468789.1_5'UTR|MECOM_ENST00000464456.1_5'UTR|MECOM_ENST00000494292.1_Silent_p.I126I	NM_001105077.3	NP_001098547.3	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						ATTCGTCTAAGATCTGGAGGG	0.373000													25	133					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74092095	74092095	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:74092095C>T	ENST00000443185.2	-	4	2292	c.1975G>A	c.(1975-1977)Gag>Aag	p.E659K	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	659					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTAGAAGTCTCTCTGCTACTG	0.522000													24	51					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554457	135554457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135554457C>T	ENST00000372146.4	+	2	2015	c.1451C>T	c.(1450-1452)cCc>cTc	p.P484L	GTF3C4_ENST00000483873.2_3'UTR	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	484					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GCAGTGAGCCCCTGCGGTGCA	0.473000													7	77					0	0	1	0	0
PRAMEF7	441871	broad.mit.edu	37	1	12979793	12979793	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12979793G>T	ENST00000361079.2	+	4	1068	c.985G>T	c.(985-987)Gtc>Ttc	p.V329F						PRAME family member 7											endometrium(2)|kidney(5)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)	18	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCTGAGGGGTGTCACGCTGAC	0.572000													14	128					1.49906e-05	1.50194e-05	1	1	0
MYH7B	57644	broad.mit.edu	37	20	33577900	33577900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33577900G>A	ENST00000262873.7	+	19	2069	c.1977G>A	c.(1975-1977)caG>caA	p.Q659Q		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	617	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity	p.Q659H(1)		NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGAAGTCACAGAATAGGCTCC	0.547000													55	103					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699168	52699168	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52699168G>A	ENST00000293525.5	+	5	932	c.880G>A	c.(880-882)Gag>Aag	p.E294K	KRT86_ENST00000544024.1_Missense_Mutation_p.E294K|KRT86_ENST00000423955.2_Missense_Mutation_p.E294K	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	294	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		GGCTGAGGCCGAGTCCTGGTA	0.537000													25	85					0	0	1	0	0
MYL4	4635	broad.mit.edu	37	17	45299052	45299052	+	Missense_Mutation	SNP	G	G	A	rs138156448		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45299052G>A	ENST00000354968.1	+	5	446	c.318G>A	c.(316-318)atG>atA	p.M106I	MYL4_ENST00000393450.1_Missense_Mutation_p.M106I|MYL4_ENST00000572316.1_Missense_Mutation_p.M106I	NM_001002841.1	NP_001002841.1	P12829	MYL4_HUMAN	myosin, light chain 4, alkali; atrial, embryonic	106					cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			endometrium(2)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)	11						CTGAAGAGATGAATGTCAAGA	0.547000													48	55					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89925077	89925077	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89925077T>G	ENST00000405460.2	+	9	1656	c.1560T>G	c.(1558-1560)ttT>ttG	p.F520L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	520					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAATAACATTTTTTCCTATGG	0.373000													9	30					0	0	1	0	0
TDP1	55775	broad.mit.edu	37	14	90485726	90485726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90485726C>T	ENST00000335725.4	+	15	1858	c.1608C>T	c.(1606-1608)tcC>tcT	p.S536S	TDP1_ENST00000555880.1_Silent_p.S536S|TDP1_ENST00000357382.3_Silent_p.S297S|TDP1_ENST00000393454.2_Silent_p.S536S|TDP1_ENST00000393452.3_Silent_p.S536S	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	536					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGATCCGCTCCTACGAGCTCG	0.522000								Repair of DNA-protein crosslinks					10	46					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201063042	201063042	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201063042C>T	ENST00000362061.3	-	3	592	c.366G>A	c.(364-366)tgG>tgA	p.W122*	CACNA1S_ENST00000367338.3_Nonsense_Mutation_p.W122*	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	122					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCAGCACATTCCAGCCACTGC	0.547000													24	61					0	0	1	0	0
PAQR7	164091	broad.mit.edu	37	1	26189653	26189653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26189653G>A	ENST00000374296.3	-	2	1344	c.678C>T	c.(676-678)ttC>ttT	p.F226F	RP1-125I3.2_ENST00000455431.1_RNA	NM_178422.5	NP_848509.1	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	226					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		CGGAGGACACGAAGATACGAT	0.577000													29	63					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449186	104449186	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104449186C>T	ENST00000361820.3	-	2	1596	c.996G>A	c.(994-996)atG>atA	p.M332I		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	332					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GGATACTTTCCATGTCGCAGC	0.517000													13	41					0	0	1	0	0
SSUH2	51066	broad.mit.edu	37	3	8673774	8673774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:8673774C>T	ENST00000317371.4	-	12	1520	c.295G>A	c.(295-297)Gaa>Aaa	p.E99K	SSUH2_ENST00000544814.1_Missense_Mutation_p.E121K|SSUH2_ENST00000415132.1_Missense_Mutation_p.E99K|SSUH2_ENST00000341795.3_Missense_Mutation_p.E99K					ssu-2 homolog (C. elegans)																		ATCCTGGATTCACTAAAGGTC	0.413000													27	74					0	0	1	0	0
SERPINE1	5054	broad.mit.edu	37	7	100777118	100777118	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100777118C>T	ENST00000223095.4	+	5	1000	c.843C>T	c.(841-843)ctC>ctT	p.L281L	SERPINE1_ENST00000445463.2_Silent_p.L266L	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	281				QLI -> HVM (in Ref. 7; CAA31208).	angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GTGCCCAGCTCATCAGCCACT	0.587000													26	77					0	0	1	0	0
AP3B1	8546	broad.mit.edu	37	5	77425034	77425034	+	Missense_Mutation	SNP	G	G	A	rs148023800	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:77425034G>A	ENST00000255194.6	-	16	1923	c.1748C>T	c.(1747-1749)cCg>cTg	p.P583L	AP3B1_ENST00000519295.1_Missense_Mutation_p.P534L	NM_001271769.1	NP_001258698.1	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1 subunit	583					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(12)|lung(12)|prostate(1)|skin(2)|urinary_tract(1)	39		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		CTTTACATTCGGAACAATAAG	0.368000									Hermansky-Pudlak syndrome				20	62					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86415927	86415927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86415927C>T	ENST00000361669.2	+	3	1918	c.819C>T	c.(817-819)gtC>gtT	p.V273V	AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Silent_p.V145V|GRM3_ENST00000394720.2_Silent_p.V271V|GRM3_ENST00000439827.1_Silent_p.V273V	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	273					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCGTCGTGGTCCTCTTCATGC	0.672000													8	74					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204939824	204939824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204939824G>A	ENST00000367172.4	+	11	1412	c.1084G>A	c.(1084-1086)Gga>Aga	p.G362R	NFASC_ENST00000404076.1_Missense_Mutation_p.G356R|NFASC_ENST00000513543.1_Missense_Mutation_p.G373R|NFASC_ENST00000367171.4_Missense_Mutation_p.G362R|NFASC_ENST00000403080.1_Missense_Mutation_p.G362R|NFASC_ENST00000339876.6_Missense_Mutation_p.G362R|NFASC_ENST00000539706.1_Missense_Mutation_p.G373R|NFASC_ENST00000404907.1_Missense_Mutation_p.G373R|NFASC_ENST00000360049.4_Missense_Mutation_p.G373R|NFASC_ENST00000367170.4_Missense_Mutation_p.G362R|NFASC_ENST00000401399.1_Missense_Mutation_p.G362R|NFASC_ENST00000367169.4_Missense_Mutation_p.G362R|NFASC_ENST00000338586.6_Missense_Mutation_p.G362R|NFASC_ENST00000338515.6_Missense_Mutation_p.G362R			O94856	NFASC_HUMAN	neurofascin	362	Ig-like C2-type 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCGAGCCAATGGAAACCCCAA	0.532000													30	59					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179582503	179582503	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179582503C>T	ENST00000589042.1	-	87	25322	c.25098G>A	c.(25096-25098)ctG>ctA	p.L8366L	TTN_ENST00000342992.6_Silent_p.L7122L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.L8049L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8049	Ig-like 66.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAACGTCTTTCAGTTTTCTTG	0.418000													7	26					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130789654	130789654	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:130789654G>A	ENST00000276708.4	-	2	1061	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	60						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						CATTGAGGGAGAATTCAACTG	0.423000													22	52					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48312489	48312489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48312489C>T	ENST00000435803.1	+	17	3250	c.3226C>T	c.(3226-3228)Cgt>Tgt	p.R1076C		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1076					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TGAAGATTTTCGTATTTCTTT	0.378000													7	14					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7527128	7527128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7527128C>T	ENST00000313599.3	-	13	3376	c.3319G>A	c.(3319-3321)Gga>Aga	p.G1107R	CD163L1_ENST00000416109.2_Missense_Mutation_p.G1117R|CD163L1_ENST00000396630.1_Missense_Mutation_p.G1107R			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1107	SRCR 10.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						GACTCCATTCCTGTGCAGTTC	0.622000													34	71					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2946452	2946452	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2946452C>T	ENST00000396946.4	-	25	3688	c.3285G>A	c.(3283-3285)acG>acA	p.T1095T		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1095	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		ACTCCTCCTCCGTCTCAGGTC	0.682000			Mis		DLBCL								16	24					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9333729	9333729	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:9333729C>T	ENST00000261336.2	-	15	1718		c.e15-1		PZP_ENST00000381997.2_Splice_Site	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TCAAATCCACCTGTGGGAAAT	0.522000													6	38					0	0	1	0	0
KIR2DL3	3804	broad.mit.edu	37	19	55263177	55263177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55263177C>T	ENST00000342376.3	+	6	823	c.792C>T	c.(790-792)ctC>ctT	p.L264L	KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron	NM_015868.2	NP_056952.2			killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3											breast(1)|cervix(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		tcttctttctccttcATCGCT	0.522000													49	46					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44222779	44222779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44222779G>A	ENST00000244314.5	+	2	268	c.69G>A	c.(67-69)agG>agA	p.R23R		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	23						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CCAAGGAAAGGCTGGAGGCCC	0.642000													40	85					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3855571	3855571	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3855571G>A	ENST00000520002.1	-	5	1227	c.672C>T	c.(670-672)ttC>ttT	p.F224F	CSMD1_ENST00000542608.1_Silent_p.F224F|CSMD1_ENST00000539096.1_Silent_p.F224F|CSMD1_ENST00000537824.1_Silent_p.F224F|CSMD1_ENST00000602723.1_Silent_p.F224F|CSMD1_ENST00000400186.3_Silent_p.F224F|CSMD1_ENST00000602557.1_Silent_p.F224F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	224	CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACTCTGAAGGGAAGTGCGGGC	0.572000													3	5					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248437012	248437012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248437012G>A	ENST00000318021.2	-	1	126	c.105C>T	c.(103-105)acC>acT	p.T35T		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CAAACAGGGAGGTCAAAACGA	0.488000													32	77					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128865607	128865607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128865607C>T	ENST00000375990.3	+	4	704	c.301C>T	c.(301-303)Cgt>Tgt	p.R101C	UGGT1_ENST00000259253.6_Missense_Mutation_p.R125C			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	125					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TCTGTCCCTTCGTTCTTACTC	0.433000													51	102					0	0	1	0	0
SDC4	6385	broad.mit.edu	37	20	43956011	43956011	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43956011G>A	ENST00000372733.3	-	5	529	c.490C>T	c.(490-492)Ctg>Ttg	p.L164L	SDC4_ENST00000537976.1_Silent_p.L92L	NM_002999.3	NP_002990.2	P31431	SDC4_HUMAN	syndecan 4	164						extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity		SDC4/ROS1(7)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)	5		Myeloproliferative disorder(115;0.0122)				AGTAGGATCAGGAAGACGGCA	0.532000			T	ROS1	NSCLC								14	58					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110831646	110831646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110831646G>A	ENST00000375820.4	-	30	2437	c.2316C>T	c.(2314-2316)atC>atT	p.I772I		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	772	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CAGGGGGTCCGATCGCTCCAT	0.577000													32	81					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784861	82784861	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82784861G>A	ENST00000423517.2	-	2	1433	c.1096C>T	c.(1096-1098)Ctt>Ttt	p.L366F	PCLO_ENST00000333891.8_Missense_Mutation_p.L366F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	326	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.P365_L366insRLSWRLSRTK(2)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCAGGACCAAGAGGCTGAGCT	0.577000													8	38					0	0	1	0	0
FAM117B	150864	broad.mit.edu	37	2	203630246	203630246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:203630246C>T	ENST00000303116.6	+	8	1539	c.797C>T	c.(796-798)tCt>tTt	p.S266F	FAM117B_ENST00000392238.2_Missense_Mutation_p.S510F	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	510										breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						AAAAGTGGATCTGCTTTCTGC	0.483000													37	159					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23728509	23728509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23728509C>T	ENST00000304749.2	-	3	440	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K	CST1_ENST00000398402.1_Missense_Mutation_p.E124K	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	124						extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					CAGGGAACTTCGTAGATCTCG	0.527000													31	34					0	0	1	0	0
FCGR3A	2214	broad.mit.edu	37	1	161519511	161519511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161519511G>A	ENST00000367969.3	-	1	307	c.124C>T	c.(124-126)Ctc>Ttc	p.L42F	FCGR3A_ENST00000436743.1_Missense_Mutation_p.L6F|FCGR3A_ENST00000476031.1_5'UTR|FCGR3A_ENST00000540048.1_Intron|FCGR3A_ENST00000443193.1_Missense_Mutation_p.L42F	NM_000569.6	NP_000560.5	P08637	FCG3A_HUMAN	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	6	Ig-like C2-type 1.				immune response|regulation of immune response	extracellular region|integral to membrane|plasma membrane	IgG binding|receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCAGTTGGGAGGAGCAGCTGC	0.532000													17	49					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90816375	90816375	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:90816375C>T	ENST00000394980.1	+	2	572	c.253C>T	c.(253-255)Ccc>Tcc	p.P85S	MMRN1_ENST00000264790.2_Missense_Mutation_p.P85S|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	85					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AACACTGCCTCCCTCAGAAAC	0.478000													20	47					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93106913	93106913	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:93106913G>A	ENST00000359558.2	-	6	626	c.327C>T	c.(325-327)tcC>tcT	p.S109S	CALCR_ENST00000426151.1_Silent_p.S91S|CALCR_ENST00000360249.4_Silent_p.S91S|CALCR_ENST00000394441.1_Silent_p.S91S|CALCR_ENST00000421592.1_Silent_p.S91S	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	91					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding	p.S91S(1)|p.S109S(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	AGAACTGATAGGACAATACTC	0.423000													15	45					0	0	1	0	0
C11orf88	399949	broad.mit.edu	37	11	111385654	111385654	+	Missense_Mutation	SNP	C	C	T	rs4418847		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111385654C>T	ENST00000529167.1	+	1	145	c.145C>T	c.(145-147)Cct>Tct	p.P49S	C11orf88_ENST00000375618.4_Missense_Mutation_p.P49S|C11orf88_ENST00000332814.6_Missense_Mutation_p.P49S|RP11-794P6.6_ENST00000530283.1_RNA			Q6PI97	CK088_HUMAN	chromosome 11 open reading frame 88	49										endometrium(1)|large_intestine(3)|lung(2)	6						GATGTATCCCCCTAGCGAATC	0.597000											OREG0021329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	78					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167993	140167993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140167993G>A	ENST00000504120.2	+	1	2118	c.2118G>A	c.(2116-2118)gcG>gcA	p.A706A	PCDHA1_ENST00000378133.3_Silent_p.A706A|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATCTGCGCGGTGTCCAGCC	0.682000													35	76					0	0	1	0	0
ACD	65057	broad.mit.edu	37	16	67694215	67694215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67694215G>A	ENST00000219251.8	-	1	498	c.167C>T	c.(166-168)cCa>cTa	p.P56L	ACD_ENST00000393919.4_Missense_Mutation_p.P56L	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	56					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTCCTTCGCTGGGCGGGGCCG	0.741000													5	32					0	0	1	0	0
TFPI2	7980	broad.mit.edu	37	7	93516176	93516176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:93516176G>A	ENST00000222543.5	-	5	976	c.664C>T	c.(664-666)Cgc>Tgc	p.R222C	GNGT1_ENST00000455502.1_Intron|TFPI2_ENST00000545378.1_Missense_Mutation_p.R111C	NM_006528.3	NP_006519.1	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2	222					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity	p.R222C(1)		endometrium(1)|large_intestine(5)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			CTGGCAAAGCGAAGCTTTGGC	0.328000													48	121					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	517561	517561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:517561C>T	ENST00000453061.2	+	9	2034	c.1928C>T	c.(1927-1929)tCc>tTc	p.S643F	PIGG_ENST00000383028.4_Missense_Mutation_p.S510F|PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000310340.5_Missense_Mutation_p.S635F|PIGG_ENST00000504346.1_Missense_Mutation_p.S554F	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	643					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CCCTCTACCTCCGAAGTGCTC	0.637000													15	48					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87772351	87772351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87772351C>T	ENST00000398204.4	+	15	1554	c.1231C>T	c.(1231-1233)Cct>Tct	p.P411S	ADAM22_ENST00000398209.3_Missense_Mutation_p.P411S|ADAM22_ENST00000265727.7_Missense_Mutation_p.P411S|ADAM22_ENST00000398201.4_Missense_Mutation_p.P411S|ADAM22_ENST00000315984.7_Missense_Mutation_p.P411S	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	411	Peptidase M12B.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CTATTATCTTCCTAAAAAGTT	0.343000													38	105					0	0	1	0	0
ACTC1	70	broad.mit.edu	37	15	35083487	35083487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:35083487G>A	ENST00000290378.4	-	6	1473	c.818C>T	c.(817-819)tCt>tTt	p.S273F	RP11-814P5.1_ENST00000503496.1_RNA|ACTC1_ENST00000557860.1_5'UTR	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	273					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GATGCCAGCAGATTCCATACC	0.468000													19	79					0	0	1	0	0
C8orf47	203111	broad.mit.edu	37	8	99101478	99101478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:99101478C>T	ENST00000318528.3	+	2	592	c.233C>T	c.(232-234)cCc>cTc	p.P78L	C8orf47_ENST00000545282.1_Intron	NM_173549.2	NP_775820.2	Q6P6B1	CH047_HUMAN	chromosome 8 open reading frame 47	78										kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(2)	13	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			GGTGTTAAACCCCTCCAAGAA	0.527000													30	113					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29642576	29642576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:29642576C>T	ENST00000373779.3	+	24	3555	c.3426C>T	c.(3424-3426)atC>atT	p.I1142I	PTPRU_ENST00000323874.8_Silent_p.I1148I|PTPRU_ENST00000356870.3_Silent_p.I1148I|PTPRU_ENST00000345512.3_Silent_p.I1152I|PTPRU_ENST00000428026.2_Silent_p.I1139I|PTPRU_ENST00000460170.2_Silent_p.I1148I	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1152	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		AGACCACCATCCCTGTCAGTG	0.552000													17	59					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53227577	53227577	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53227577G>A	ENST00000330553.5	-	1	502	c.468C>T	c.(466-468)ttC>ttT	p.F156F		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	156	Coil 1A.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCTTGTCGATGAAGGAGGCGA	0.607000													32	234					0	0	1	0	0
FAM217A	222826	broad.mit.edu	37	6	4069751	4069751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:4069751C>T	ENST00000274673.3	-	7	1109	c.706G>A	c.(706-708)Gaa>Aaa	p.E236K	FAM217A_ENST00000380188.2_5'UTR	NM_173563.2	NP_775834.2	Q8IXS0	CF146_HUMAN	family with sequence similarity 217, member A	236																	GTGAAAGGTTCCTCAACATTT	0.378000													47	114					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82323694	82323694	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:82323694C>T	ENST00000376520.4	+	14	2180	c.1352C>T	c.(1351-1353)tCa>tTa	p.S451L	TLE4_ENST00000376534.4_Missense_Mutation_p.S56L|TLE4_ENST00000265284.6_Missense_Mutation_p.S394L|TLE4_ENST00000376544.3_Missense_Mutation_p.S350L|TLE4_ENST00000376552.2_Missense_Mutation_p.S419L|TLE4_ENST00000376537.4_Missense_Mutation_p.S451L			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TATGGGAGATCACCAGTGGTG	0.582000													9	25					0	0	1	0	0
SLC9A1	6548	broad.mit.edu	37	1	27436206	27436206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27436206G>A	ENST00000263980.3	-	3	1451	c.876C>T	c.(874-876)ttC>ttT	p.F292F	SLC9A1_ENST00000374086.3_Silent_p.F292F|SLC9A1_ENST00000545949.1_5'UTR	NM_003047.4	NP_003038.2	P19634	SL9A1_HUMAN	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	292					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	GGAAGCCGAGGAAGATGTCCA	0.612000													37	105					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86524856	86524856	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86524856C>T	ENST00000370571.2	-	9	2120	c.1752_splice	c.e9-1	p.G585_splice	COL24A1_ENST00000436319.1_Splice_Site_p.G585_splice	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	585	Collagen-like 2.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCCTGGAATTCCCTGAAATAA	0.333000													13	50					0	0	1	0	0
TCF20	6942	broad.mit.edu	37	22	42608869	42608869	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42608869G>A	ENST00000359486.3	-	1	2579	c.2443C>T	c.(2443-2445)Ccc>Tcc	p.P815S	TCF20_ENST00000335626.4_Missense_Mutation_p.P815S	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	815					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CCCCAGTGGGGATTTTCTAAT	0.443000													30	70					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34038291	34038291	+	Splice_Site	SNP	G	G	A	rs139241831		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34038291G>A	ENST00000373381.4	-	50	7753	c.7576_splice	c.e50-1	p.A2526_splice		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2528	Sushi 14.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACAGGAAAGAGCTAGCAAAAG	0.448000													15	63					0	0	1	0	0
FAM111A	63901	broad.mit.edu	37	11	58920793	58920793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58920793C>T	ENST00000528737.1	+	5	4470	c.1652C>T	c.(1651-1653)tCa>tTa	p.S551L	FAM111A_ENST00000531147.1_Missense_Mutation_p.S551L|FAM111A_ENST00000420244.1_Missense_Mutation_p.S551L|FAM111A_ENST00000361723.3_Missense_Mutation_p.S551L|FAM111A_ENST00000533703.1_Missense_Mutation_p.S551L			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	551					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				TCAAAAGGTTCATTGGTGGCC	0.428000													59	131					0	0	1	0	0
TMEM65	157378	broad.mit.edu	37	8	125332403	125332403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125332403G>A	ENST00000297632.6	-	6	1079	c.545C>T	c.(544-546)tCc>tTc	p.S182F		NM_194291.2	NP_919267.2	Q6PI78	TMM65_HUMAN	transmembrane protein 65	182						integral to membrane				cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	6	Lung NSC(37;1.18e-11)|Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GCCTAACCTGGAAGCCAATGC	0.368000													47	65					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36784456	36784456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36784456G>A	ENST00000361475.2	-	3	399	c.226C>T	c.(226-228)Cgt>Tgt	p.R76C	TGM2_ENST00000536701.1_Intron|TGM2_ENST00000536724.1_Missense_Mutation_p.R16C	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2	76			R -> H (in dbSNP:rs41274720).		apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	AGTGGAAAACGGGCCTTGGTC	0.657000													5	21					0	0	1	0	0
CXCR3	2833	broad.mit.edu	37	X	70836294	70836294	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70836294C>T	ENST00000373691.4	-	2	1332	c.1169G>A	c.(1168-1170)gGg>gAg	p.G390E	CXCR3_ENST00000373693.3_Missense_Mutation_p.G343E	NM_001142797.1	NP_001136269.1	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3	343					cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|central_nervous_system(2)|large_intestine(2)|lung(3)|ovary(2)	10	Renal(35;0.156)					CCTCTGGAGCCCTCTCTGGTT	0.637000													5	13					0	0	1	0	0
CHMP4C	92421	broad.mit.edu	37	8	82670728	82670728	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:82670728G>A	ENST00000297265.4	+	5	844	c.651G>A	c.(649-651)agG>agA	p.R217R		NM_152284.3	NP_689497.1	Q96CF2	CHM4C_HUMAN	charged multivesicular body protein 4C	217	Intramolecular interaction with N- terminus (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	10						CTTCCCAGAGGGCAGAAGAAG	0.313000													19	85					0	0	1	0	0
GSDMB	55876	broad.mit.edu	37	17	38062518	38062518	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38062518G>A	ENST00000394175.2	-	5	891	c.668C>T	c.(667-669)tCt>tTt	p.S223F	GSDMB_ENST00000418519.1_Missense_Mutation_p.S245F|GSDMB_ENST00000394179.1_Missense_Mutation_p.S240F|GSDMB_ENST00000360317.3_Missense_Mutation_p.S245F|GSDMB_ENST00000309481.7_Missense_Mutation_p.S232F|GSDMB_ENST00000520542.1_Missense_Mutation_p.S236F	NM_018530.2	NP_061000.2	Q8TAX9	GSDMB_HUMAN	gasdermin B	240						cytoplasm				breast(2)|endometrium(3)|large_intestine(6)|lung(6)|pancreas(1)|prostate(1)|stomach(2)	21						CGAACCCAAAGACTTTCCTGT	0.473000													27	38					0	0	1	0	0
VASH2	79805	broad.mit.edu	37	1	213147345	213147345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:213147345G>A	ENST00000366968.4	+	8	1083	c.733G>A	c.(733-735)Gga>Aga	p.G245R	VASH2_ENST00000366967.2_Missense_Mutation_p.G206R|VASH2_ENST00000517399.1_Missense_Mutation_p.G310R|VASH2_ENST00000366966.2_Missense_Mutation_p.G245R|VASH2_ENST00000271776.4_3'UTR|VASH2_ENST00000366965.2_Missense_Mutation_p.G266R	NM_001136474.1	NP_001129946.1	Q86V25	VASH2_HUMAN	vasohibin 2	310					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		GAGAAGCCGGGGAAAATCCCT	0.572000													13	60					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288840	107288840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107288840G>A	ENST00000277216.3	-	1	650	c.651C>T	c.(649-651)tcC>tcT	p.S217S		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						TGAACATATAGGAGAAAAAAA	0.408000													10	112					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71602144	71602144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71602144G>A	ENST00000355962.4	-	12	1401	c.1268C>T	c.(1267-1269)cCc>cTc	p.P423L	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	423					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CATCACCTCGGGGACTGTGAT	0.522000													9	48					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36872942	36872942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36872942G>A	ENST00000301807.6	-	21	8247	c.6350C>T	c.(6349-6351)tCc>tTc	p.S2117F	TRANK1_ENST00000429976.2_Missense_Mutation_p.S2667F|TRANK1_ENST00000428977.2_Missense_Mutation_p.S2117F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2667					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TTGCTTTTGGGAAAGAATGGT	0.542000													4	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179501491	179501491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179501491C>T	ENST00000589042.1	-	225	41187	c.40963G>A	c.(40963-40965)Gaa>Aaa	p.E13655K	TTN-AS1_ENST00000418062.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E11087K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E4590K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E4782K|TTN_ENST00000359218.5_Missense_Mutation_p.E4715K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E12014K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12014	Ig-like 92.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E4590K(1)|p.E4782K(1)|p.E11087K(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTCCTTTCGGCTTCTATT	0.433000													17	54					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115590997	115590997	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:115590997C>T	ENST00000265440.7	-	6	626	c.446G>A	c.(445-447)aGa>aAa	p.R149K	TFEC_ENST00000320239.7_Missense_Mutation_p.R120K|TFEC_ENST00000457268.1_Missense_Mutation_p.R82K|TFEC_ENST00000484212.1_Missense_Mutation_p.R239K|TFEC_ENST00000393485.1_Missense_Mutation_p.R120K	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	149	Helix-loop-helix motif.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			CCTTCTTCTTCTTTCAACTAT	0.284000													14	40					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209788748	209788748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209788748C>T	ENST00000391911.1	-	22	3776	c.3387G>A	c.(3385-3387)atG>atA	p.M1129I	LAMB3_ENST00000356082.4_Missense_Mutation_p.M1129I|LAMB3_ENST00000367030.3_Missense_Mutation_p.M1129I	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1129	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GCTCCAACTCCATGTCTGAGG	0.587000													12	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179436900	179436900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179436900C>T	ENST00000589042.1	-	326	74183	c.73959G>A	c.(73957-73959)gtG>gtA	p.V24653V	TTN_ENST00000342992.6_Silent_p.V22085V|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Silent_p.V15588V|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.V15780V|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Silent_p.V15713V|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Silent_p.V23012V|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23012	Fibronectin type-III 79.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGCATCTCCACAATGTAGC	0.458000													14	21					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55421210	55421210	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55421210C>T	ENST00000242994.3	+	2	1365	c.987C>T	c.(985-987)ttC>ttT	p.F329F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	329					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						ATACAGTCTTCACTGAGTGAG	0.428000													161	300					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65272664	65272664	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65272664C>T	ENST00000534336.1	+	0	7432					NR_002819.2																						TCAGGTACCCCTCACTAAAGG	0.498000													18	36					0	0	1	0	0
RFPL1	5988	broad.mit.edu	37	22	29837927	29837927	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29837927C>T	ENST00000354373.2	+	2	979	c.770C>T	c.(769-771)tCc>tTc	p.S257F	RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	257	B30.2/SPRY.						zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						CAGAACGTTTCCTTTTTTGAT	0.507000													35	97					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6511792	6511792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6511792G>A	ENST00000377828.1	+	9	2213	c.2045G>A	c.(2044-2046)gGg>gAg	p.G682E	ESPN_ENST00000461727.1_Missense_Mutation_p.G116E|ESPN_ENST00000475228.1_3'UTR|ESPN_ENST00000416731.1_Missense_Mutation_p.G116E	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	682	Pro-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		TCAGGCATCGGGCAGCCGGCC	0.682000													7	18					0	0	1	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87329812	87329812	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87329812C>T	ENST00000338056.3	+	4	776	c.365C>T	c.(364-366)tCa>tTa	p.S122L	RUNDC3B_ENST00000493037.1_Missense_Mutation_p.S105L|ABCB1_ENST00000265724.3_Intron|RUNDC3B_ENST00000394654.3_Missense_Mutation_p.S105L	NM_001134405.1|NM_138290.2	NP_001127877.1|NP_612147.1	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B	122	RUN.									breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(2)	26	Esophageal squamous(14;0.00164)					CGGAAAGTTTCACAGAATTGT	0.383000													26	55					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56372893	56372893	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56372893C>T	ENST00000301295.6	+	4	2420	c.1998C>T	c.(1996-1998)agC>agT	p.S666S	NLRP4_ENST00000346986.5_Silent_p.S666S|NLRP4_ENST00000587891.1_Silent_p.S591S	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	666							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGCATCCCAGCTGTCGCCTTC	0.557000													24	58					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32624481	32624481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32624481C>T	ENST00000286827.3	-	6	1459	c.988G>A	c.(988-990)Gag>Aag	p.E330K	TIAM1_ENST00000541036.1_Missense_Mutation_p.E330K|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	330					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TCTGCAAACTCACTGCCCTCG	0.572000													74	233					0	0	1	0	0
TCN1	6947	broad.mit.edu	37	11	59630139	59630139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59630139G>A	ENST00000257264.3	-	3	420	c.316C>T	c.(316-318)Cgt>Tgt	p.R106C	TCN1_ENST00000532419.1_5'UTR	NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	106					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCAGCGTTACGACATACTCCC	0.358000													33	106					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227895207	227895207	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227895207G>A	ENST00000396625.3	-	41	4132	c.3925C>T	c.(3925-3927)Cca>Tca	p.P1309S	COL4A4_ENST00000329662.7_Missense_Mutation_p.P1309S	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1309	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTGTATCCTGGAGGGCCTGGT	0.537000													33	109					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151156198	151156198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151156198G>A	ENST00000282466.3	-	6	6150	c.6151C>T	c.(6151-6153)Ctc>Ttc	p.L2051F	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2051	Ig-like C2-type 7.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTCCCATGGAGCACTTGCTTT	0.438000													41	125					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101413856	101413856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101413856G>A	ENST00000392979.3	+	8	1035	c.674G>A	c.(673-675)aGa>aAa	p.R225K	ANO4_ENST00000538618.1_3'UTR|ANO4_ENST00000392977.3_Missense_Mutation_p.R260K|ANO4_ENST00000299222.9_5'UTR	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	260						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						AATGCCACAAGAAGTAGAATC	0.308000										HNSCC(74;0.22)			27	55					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121980436	121980436	+	Missense_Mutation	SNP	G	G	A	rs104893689		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121980436G>A	ENST00000498619.1	+	4	992	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	CASR_ENST00000296154.5_Missense_Mutation_p.R185Q|CASR_ENST00000490131.1_Missense_Mutation_p.R185Q	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	185			R -> Q (in FHH).		anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TCTTTCCTCCGAACCATCCCC	0.502000													58	156					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162696315	162696315	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:162696315G>A	ENST00000375514.5	+	5	614	c.327G>A	c.(325-327)agG>agA	p.R109R	SLC4A10_ENST00000446997.1_Silent_p.R98R|SLC4A10_ENST00000272716.5_Silent_p.R98R|SLC4A10_ENST00000493021.1_3'UTR|SLC4A10_ENST00000421911.1_Silent_p.R98R|SLC4A10_ENST00000535165.1_Silent_p.R98R|SLC4A10_ENST00000415876.2_Silent_p.R98R	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	98					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CATCACAGAGGGTACAGTTTA	0.453000													15	43					0	0	1	0	0
DDX25	29118	broad.mit.edu	37	11	125787074	125787074	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:125787074G>A	ENST00000263576.6	+	9	1121	c.966G>A	c.(964-966)agG>agA	p.R322R	RP11-680F20.9_ENST00000533033.2_RNA|DDX25_ENST00000525943.1_3'UTR	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	322	Helicase C-terminal.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		GTGAGCACAGGAAAGACAAAT	0.468000													8	16					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72267089	72267089	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:72267089C>T	ENST00000340726.3	-	3	691	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	EYA1_ENST00000303824.7_Missense_Mutation_p.E18K|EYA1_ENST00000388742.4_Missense_Mutation_p.E18K|EYA1_ENST00000388741.2_Intron|EYA1_ENST00000388743.2_Missense_Mutation_p.E18K|EYA1_ENST00000388740.3_Intron|EYA1_ENST00000419131.1_Missense_Mutation_p.E18K	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	18					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTGGGGGATTCACTACTACCA	0.453000													50	132					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111077171	111077171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111077171G>A	ENST00000360467.5	+	5	577	c.271G>A	c.(271-273)Ggt>Agt	p.G91S		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	91					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGGAGACAAGGGTGAAAGGGG	0.637000													25	64					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43610472	43610472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43610472C>T	ENST00000372806.3	+	4	343	c.248C>T	c.(247-249)cCt>cTt	p.P83L	STK4_ENST00000396731.4_Missense_Mutation_p.P83L|STK4_ENST00000372801.1_Missense_Mutation_p.P83L|STK4_ENST00000499879.2_Missense_Mutation_p.P83L	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	83	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				CTCTCTAGCCCTCATGTAGTC	0.343000													16	53					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44934018	44934018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44934018C>T	ENST00000291187.4	-	6	1242	c.920G>A	c.(919-921)aGa>aAa	p.R307K	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Missense_Mutation_p.R313K	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				TGTGGGAACTCTTTGATGTCT	0.507000													7	38					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34022007	34022007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34022007C>T	ENST00000374372.1	-	4	1709	c.1206G>A	c.(1204-1206)cgG>cgA	p.R402R	GDF5OS_ENST00000374375.1_Silent_p.F17F|GDF5_ENST00000374369.3_Silent_p.R402R			P43026	GDF5_HUMAN	growth differentiation factor 5	402					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GCAGTGCCTTCCGACTGCAGC	0.607000													39	124					0	0	1	0	0
SPTLC2	9517	broad.mit.edu	37	14	78021720	78021720	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:78021720G>A	ENST00000216484.2	-	8	1292	c.1099C>T	c.(1099-1101)Ccc>Tcc	p.P367S		NM_004863.3	NP_004854.1	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base subunit 2	367						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(5)	19			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACATCCTCGGGATCCAGGCCA	0.512000													77	139					0	0	1	0	0
ARID3B	10620	broad.mit.edu	37	15	74883703	74883703	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74883703C>T	ENST00000346246.5	+	6	1324	c.1093C>T	c.(1093-1095)Ctt>Ttt	p.L365F		NM_006465.2	NP_006456.1	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B (BRIGHT-like)	365	Interaction with RB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(2)	14						CTTTCCCATCCTTGGGCTTGG	0.622000													31	171					0	0	1	0	0
ABHD14B	84836	broad.mit.edu	37	3	52003883	52003883	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52003883C>T	ENST00000461108.1	-	3	613	c.529G>A	c.(529-531)Ggg>Agg	p.G177R	ABHD14B_ENST00000395008.2_Intron|ABHD14B_ENST00000525795.1_Intron|ABHD14B_ENST00000487005.1_Intron|ABHD14B_ENST00000315877.10_Intron|RP11-155D18.12_ENST00000488257.1_RNA|ABHD14B_ENST00000361143.5_Intron|ABHD14B_ENST00000483233.1_Intron			Q96IU4	ABHEB_HUMAN	abhydrolase domain containing 14B	0						cytoplasm|nucleus	hydrolase activity			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000548)|KIRC - Kidney renal clear cell carcinoma(197;0.00072)		TTATCCAGCCCCCAGATGAGG	0.562000													8	38					0	0	1	0	0
TEC	7006	broad.mit.edu	37	4	48169959	48169959	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48169959G>A	ENST00000381501.3	-	7	664	c.507C>T	c.(505-507)ccC>ccT	p.P169P		NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	169					intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						GAATTGGTGGGGGAGGCCTTC	0.383000													11	101					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22838343	22838343	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22838343C>T	ENST00000404138.1	+	12	2688	c.2177C>T	c.(2176-2178)tCa>tTa	p.S726L	ZBTB40_ENST00000374651.4_Missense_Mutation_p.S614L|ZBTB40_ENST00000375647.4_Missense_Mutation_p.S726L	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	726					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		AAAGAGGCTTCAGCCTCCCCA	0.527000													13	43					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137777102	137777102	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137777102G>A	ENST00000350339.2	+	4	219	c.205G>A	c.(205-207)Gac>Aac	p.D69N	FCN2_ENST00000291744.6_Missense_Mutation_p.D107N	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	107	Collagen-like.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		TACCTGCAAGGACCTGCTAGA	0.667000													12	35					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369238	22369238	+	Silent	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22369238T>G	ENST00000332663.2	+	1	761	c.663T>G	c.(661-663)ctT>ctG	p.L221L	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ATGCCTTCCTTCTGGCCTTGT	0.478000													52	125					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67155970	67155970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:67155970C>T	ENST00000371037.4	+	17	1618	c.1541C>T	c.(1540-1542)tCc>tTc	p.S514F	SGIP1_ENST00000371035.3_Missense_Mutation_p.S304F|SGIP1_ENST00000371036.3_Missense_Mutation_p.S314F|SGIP1_ENST00000371039.1_Missense_Mutation_p.S315F|SGIP1_ENST00000237247.6_Missense_Mutation_p.S545F	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	514					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						TCAACCAATTCCTTGAGCGCA	0.468000													68	175					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	626031	626031	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:626031C>T	ENST00000470411.2	+	3	926	c.882C>T	c.(880-882)tcC>tcT	p.S294S	PIGQ_ENST00000409527.2_Intron|PIGQ_ENST00000321878.5_Intron|PIGQ_ENST00000026218.5_Intron			Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	0	Leu-rich.				C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				CTTCTCCATCCCCCTCTGCAC	0.711000													4	2					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104031893	104031893	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104031893G>A	ENST00000388887.2	+	8	1013	c.809G>A	c.(808-810)gGg>gAg	p.G270E		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	270	EGF-like 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GGCTACCGTGGGGATGGCCAA	0.502000													28	83					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169111329	169111329	+	Missense_Mutation	SNP	G	G	A	rs139449745		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169111329G>A	ENST00000256935.8	+	8	816	c.736G>A	c.(736-738)Gac>Aac	p.D246N		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	246					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCTCTCTACGACCCCAACAA	0.498000													12	151					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71218869	71218869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71218869C>T	ENST00000393567.2	-	3	310	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	HYDIN_ENST00000321489.5_Missense_Mutation_p.E54K|HYDIN_ENST00000541601.1_Missense_Mutation_p.E71K|HYDIN_ENST00000448691.1_Missense_Mutation_p.E54K|HYDIN_ENST00000288168.10_Missense_Mutation_p.E71K|HYDIN_ENST00000393550.2_Missense_Mutation_p.E54K|HYDIN_ENST00000538248.1_Missense_Mutation_p.E81K|HYDIN_ENST00000448089.2_Missense_Mutation_p.E54K	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	54								p.E54K(2)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGGGACATTTCCTTCAGGAAC	0.408000													20	70					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90254384	90254384	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90254384C>T	ENST00000469640.2	+	5	914	c.539C>T	c.(538-540)aCt>aTt	p.T180I	DAPK1_ENST00000408954.3_Missense_Mutation_p.T180I|DAPK1_ENST00000358077.5_Missense_Mutation_p.T180I|DAPK1_ENST00000472284.1_Missense_Mutation_p.T180I|DAPK1_ENST00000491893.1_Missense_Mutation_p.T180I			P53355	DAPK1_HUMAN	death-associated protein kinase 1	180	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						ATATTTGGGACTCCAGAGTTT	0.398000									Chronic Lymphocytic Leukemia, Familial Clustering of				26	101					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169690823	169690823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169690823G>A	ENST00000444448.2	+	9	968	c.492G>A	c.(490-492)aaG>aaA	p.K164K	NOSTRIN_ENST00000421711.2_Silent_p.K136K|NOSTRIN_ENST00000397206.2_Silent_p.K86K|NOSTRIN_ENST00000458381.2_Silent_p.K164K|NOSTRIN_ENST00000317647.7_Silent_p.K164K|NOSTRIN_ENST00000445023.2_Silent_p.K86K|NOSTRIN_ENST00000397209.2_Silent_p.K136K			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	164					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						TGACTGAGAAGGAGAAGCGGA	0.463000													14	56					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175897751	175897751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175897751G>A	ENST00000359240.3	+	5	1745	c.1075G>A	c.(1075-1077)Ggc>Agc	p.G359S	ADAM29_ENST00000404450.4_Missense_Mutation_p.G359S|ADAM29_ENST00000445694.1_Missense_Mutation_p.G359S|ADAM29_ENST00000514159.1_Missense_Mutation_p.G359S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	359	Peptidase M12B.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		AATGCATGAAGGCAACCCACC	0.373000													47	111					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152329580	152329580	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152329580C>T	ENST00000388718.5	-	3	754	c.682G>A	c.(682-684)Gga>Aga	p.G228R	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	228	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTTTGATCCAGATCCAGAT	0.438000													80	234					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9801402	9801402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9801402C>T	ENST00000256460.3	-	9	955	c.778G>A	c.(778-780)Gac>Aac	p.D260N	OGG1_ENST00000302036.7_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302008.8_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	260	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TTCTCTGGGTCCTTCTCCATC	0.517000													78	159					0	0	1	0	0
EPN3	55040	broad.mit.edu	37	17	48613885	48613885	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48613885G>A	ENST00000537145.1	+	2	352	c.215G>A	c.(214-216)gGg>gAg	p.G72E	EPN3_ENST00000268933.3_5'UTR|EPN3_ENST00000541226.1_5'UTR			Q9H201	EPN3_HUMAN	epsin 3	208	ENTH.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CCTCCGGCGGGGGCGAGGGCC	0.622000													21	61					0	0	1	0	0
MYO1C	4641	broad.mit.edu	37	17	1371776	1371776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:1371776G>A	ENST00000359786.5	-	26	2949	c.2625C>T	c.(2623-2625)gcC>gcT	p.A875A	MYO1C_ENST00000545534.2_Silent_p.A851A|MYO1C_ENST00000438665.2_Silent_p.A856A|MYO1C_ENST00000361007.2_Silent_p.A840A|MYO1C_ENST00000575158.1_Silent_p.A840A	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	875					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CACTAGCCACGGCCTTCTGCT	0.587000													19	26					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75499524	75499524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75499524C>T	ENST00000360639.2	+	2	1455	c.1135C>T	c.(1135-1137)Cct>Tct	p.P379S	C15orf39_ENST00000394987.4_Missense_Mutation_p.P379S|C15orf39_ENST00000567617.1_Missense_Mutation_p.P379S			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	379										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						ACTGAGTTTTCCTTATGCCCG	0.627000													150	184					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81744996	81744996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81744996G>A	ENST00000555447.1	-	6	1071	c.659C>T	c.(658-660)cCt>cTt	p.P220L	STON2_ENST00000556280.1_5'UTR|STON2_ENST00000267540.2_Missense_Mutation_p.P220L	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	220					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TGGAGGGGCAGGGTGCCCATT	0.532000													27	49					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27333047	27333047	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:27333047G>A	ENST00000429845.2	-	18	1766	c.1404C>T	c.(1402-1404)ttC>ttT	p.F468F	NEK10_ENST00000341435.5_Silent_p.F468F			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	468							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CTATGTCAATGAAGATCTCAA	0.348000													11	21					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14905687	14905687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14905687G>A	ENST00000285046.5	+	2	2688	c.2578G>A	c.(2578-2580)Gag>Aag	p.E860K	FGD5_ENST00000543601.1_Missense_Mutation_p.E619K	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	860					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						AGCCCCCAAAGAGGACCTTAC	0.547000													21	57					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22130333	22130333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:22130333C>T	ENST00000389398.5	+	12	1197	c.1101C>T	c.(1099-1101)acC>acT	p.T367T	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	367						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		AGGCGCTCACCTGCACCATGG	0.617000													5	10					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152057846	152057846	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152057846G>A	ENST00000368806.1	-	3	2376	c.2312C>T	c.(2311-2313)tCt>tTt	p.S771F		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	771							calcium ion binding	p.S771Y(1)		breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GGGGACTGAAGAATTGTGCTC	0.493000													26	124					0	0	1	0	0
MIR518F	574472	broad.mit.edu	37	19	54203316	54203316	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54203316G>A	ENST00000384973.1	+	0	48					NR_030194.1																						TTGTCTAAAAGAAAAGAAAGC	0.388000													26	113					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70257751	70257751	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70257751G>A	ENST00000310961.5	+	5	648	c.230G>A	c.(229-231)cGa>cAa	p.R77Q	LRRC7_ENST00000370958.1_Missense_Mutation_p.R110Q|LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.R72Q			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	72						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CAAGCTCTACGAAAACTAAGT	0.294000													26	78					0	0	1	0	0
SYT13	57586	broad.mit.edu	37	11	45277287	45277287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:45277287G>A	ENST00000020926.3	-	2	450	c.339C>T	c.(337-339)agC>agT	p.S113S		NM_001247987.1|NM_020826.2	NP_001234916.1|NP_065877.1	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	113						transport vesicle				breast(1)|large_intestine(3)|lung(16)|ovary(1)|skin(2)	23						GGGGTTGGGGGCTGGCAGGTG	0.587000													9	29					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531517	92531517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92531517G>A	ENST00000298047.6	+	9	5355	c.5338G>A	c.(5338-5340)Gag>Aag	p.E1780K	FAT3_ENST00000409404.2_Missense_Mutation_p.E1780K|FAT3_ENST00000525166.1_Missense_Mutation_p.E1630K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1780	Cadherin 16.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGCCTAAGTGAGGCTGCCCC	0.458000										TCGA Ovarian(4;0.039)			14	21					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110448612	110448612	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110448612C>T	ENST00000378402.5	+	30	3655	c.3551C>T	c.(3550-3552)tCa>tTa	p.S1184L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1184	IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity	p.S1186L(1)		NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AATGAAAATTCAAAGGTATTA	0.348000										HNSCC(38;0.096)			21	51					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94884136	94884136	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94884136G>A	ENST00000331706.4	+	0	1017				MCTP2_ENST00000543482.1_Missense_Mutation_p.G318S|MCTP2_ENST00000451018.3_Missense_Mutation_p.G318S|MCTP2_ENST00000357742.4_Missense_Mutation_p.G318S			Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GGTAAAACAGGGTGATTTCAA	0.373000													14	71					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43285837	43285837	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:43285837C>T	ENST00000374518.4	+	5	577	c.514C>T	c.(514-516)Caa>Taa	p.Q172*		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	172					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAACATCTGTCAAGTACATGG	0.378000													40	136					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858068	9858068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9858068G>A	ENST00000396573.2	-	14	3642	c.3333C>T	c.(3331-3333)agC>agT	p.S1111S	GRIN2A_ENST00000404927.2_Silent_p.S1111S|GRIN2A_ENST00000562109.1_Silent_p.S1111S|GRIN2A_ENST00000330684.3_Silent_p.S1111S|GRIN2A_ENST00000396575.2_Silent_p.S1111S|GRIN2A_ENST00000535259.1_Silent_p.S954S	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1111					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.S1111R(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTCTAGGGGAGCTTGATTTGG	0.483000													47	103					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56650809	56650809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56650809G>A	ENST00000267116.7	-	4	372	c.251C>T	c.(250-252)tCc>tTc	p.S84F		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	84							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						CTCGTTTCGGGAGGCAGCAGC	0.498000													4	34					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167240254	167240254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167240254C>T	ENST00000308378.3	-	12	1872	c.1567G>A	c.(1567-1569)Gaa>Aaa	p.E523K	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Intron|WDR49_ENST00000476376.1_Missense_Mutation_p.E348K	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	523										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						AGGCAGTTTTCAATATGCCAG	0.313000													17	57					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539234	55539234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55539234C>T	ENST00000220676.1	+	4	2940	c.2792C>T	c.(2791-2793)cCt>cTt	p.P931L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	931					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACTTTAAAGCCTATAAAATCA	0.323000													15	45					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128322868	128322868	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128322868C>T	ENST00000389524.4	+	4	246	c.193C>T	c.(193-195)Cag>Tag	p.Q65*	MYO7B_ENST00000428314.1_Nonsense_Mutation_p.Q65*|MYO7B_ENST00000409816.2_Nonsense_Mutation_p.Q65*			Q6PIF6	MYO7B_HUMAN	myosin VIIB	65						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CAACTCAGTCCAGGGTGTGGA	0.592000													9	44					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43683254	43683254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43683254C>T	ENST00000599812.1	-	3	581	c.486G>A	c.(484-486)atG>atA	p.M162I	PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407356.1_Intron|PSG5_ENST00000404580.1_Intron|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000342951.6_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	162	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				TCACAGCCTCCATGGCCTCCC	0.522000													79	264					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35974178	35974178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:35974178C>T	ENST00000297866.5	+	8	1341	c.1275C>T	c.(1273-1275)ttC>ttT	p.F425F		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	425										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AACCTTGTTTCATGGGTGAAC	0.363000													36	59					0	0	1	0	0
TCEB3	6924	broad.mit.edu	37	1	24082811	24082811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24082811C>T	ENST00000418390.2	+	9	2369	c.2098C>T	c.(2098-2100)Cgt>Tgt	p.R700C		NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	700	Activation domain (By similarity).				positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CAAGCCACCTCGTGACGTCCG	0.498000													3	8					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124459232	124459232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124459232C>T	ENST00000329446.4	-	1	106	c.75G>A	c.(73-75)agG>agA	p.R25R		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	25										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				TTTCATTCTTCCTTTCTTGCA	0.448000													24	65					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480398	140480398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140480398G>A	ENST00000231130.2	+	1	165	c.165G>A	c.(163-165)agG>agA	p.R55R	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		55	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGGACTAAGGGTAGAGGAAC	0.512000													29	86					0	0	1	0	0
ESYT3	83850	broad.mit.edu	37	3	138191536	138191536	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:138191536C>T	ENST00000389567.4	+	18	2258	c.2072C>T	c.(2071-2073)aCt>aTt	p.T691I		NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	691						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						ATCTTCCTGACTGTCCCAGGT	0.602000													38	105					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367233	234367233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:234367233G>A	ENST00000366618.3	+	3	499	c.354G>A	c.(352-354)ggG>ggA	p.G118G	SLC35F3_ENST00000366617.3_Silent_p.G49G	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	49					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			AGGCCGGCGGGAGAGCGAGTC	0.746000													23	37					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177608588	177608588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:177608588G>A	ENST00000280193.2	-	6	1313	c.898C>T	c.(898-900)Cgg>Tgg	p.R300W	RP11-313E19.2_ENST00000504017.1_RNA|RP11-313E19.2_ENST00000509194.1_RNA	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	300	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CTGGCAGGCCGAAGCCCCGCT	0.512000													11	122					0	0	1	0	0
HBD	3045	broad.mit.edu	37	11	5254013	5254013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5254013G>A	ENST00000292901.3	-	3	380	c.331C>T	c.(331-333)Cct>Tct	p.P111S				P02042	HBD_HUMAN	hemoglobin, delta	0					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGCCTCAGGAACCTTCTTA	0.388000													4	27					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532340	84532340	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84532340G>A	ENST00000527857.1	+	0	2362					NR_026851.1																						GGAATTATCAGGGATACAGCC	0.468000													8	46					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17483289	17483289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17483289G>A	ENST00000302539.4	-	5	788	c.663C>T	c.(661-663)ttC>ttT	p.F221F	ABCC8_ENST00000389817.3_Silent_p.F221F	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	221					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GCAGATTCACGAAGGGCTGCA	0.582000													34	93					0	0	1	0	0
UGT1A5	54579	broad.mit.edu	37	2	234621899	234621899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234621899G>A	ENST00000373414.3	+	1	262	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	UGT1A7_ENST00000373426.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A9_ENST00000354728.4_Intron	NM_019078.1	NP_061951.1														cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GACCCAGGACGAATTTGATCG	0.428000													53	113					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4703806	4703806	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4703806C>T	ENST00000302640.8	+	14	1597	c.1247C>T	c.(1246-1248)gCc>gTc	p.A416V	ITPR1_ENST00000456211.2_Missense_Mutation_p.A416V|ITPR1_ENST00000443694.2_Missense_Mutation_p.A416V|ITPR1_ENST00000357086.4_Missense_Mutation_p.A431V|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000423119.2_Missense_Mutation_p.A431V|ITPR1_ENST00000354582.6_Missense_Mutation_p.A431V	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	431	MIR 5.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GAAGCATTTGCCATAGTTCCG	0.493000													30	70					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106066395	106066395	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106066395G>A	ENST00000577108.1	-	0	136				IGHE_ENST00000576077.1_RNA																							GAGGGAGGCAGGAGTACGTCA	0.587000													21	113					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46267841	46267841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:46267841C>T	ENST00000372004.3	+	14	2818	c.2602C>T	c.(2602-2604)Cct>Tct	p.P868S	NCOA3_ENST00000341724.6_Intron|NCOA3_ENST00000371998.3_Missense_Mutation_p.P868S|NCOA3_ENST00000371997.3_Missense_Mutation_p.P878S	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	868					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TGGCTCAAGTCCTCCAGTAAA	0.438000													35	84					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115421590	115421590	+	Silent	SNP	C	C	T	rs151231750	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:115421590C>T	ENST00000337530.6	+	4	1688	c.1392C>T	c.(1390-1392)acC>acT	p.T464T	KIAA1958_ENST00000536272.1_Silent_p.T492T	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	464										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						TTTATGTCACCGTCAAGAAGA	0.542000													33	51					0	0	1	0	0
APOBEC1	339	broad.mit.edu	37	12	7805044	7805044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7805044C>T	ENST00000229304.4	-	3	452	c.432G>A	c.(430-432)atG>atA	p.M144I		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	144					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						CTGATGCTCTCATAATCTGAA	0.418000													12	54					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833244	168833244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168833244C>T	ENST00000464456.1	-	7	3052	c.1852G>A	c.(1852-1854)Gaa>Aaa	p.E618K	MECOM_ENST00000433243.2_Missense_Mutation_p.E619K|MECOM_ENST00000460814.1_Missense_Mutation_p.E618K|MECOM_ENST00000392736.3_Missense_Mutation_p.E618K|MECOM_ENST00000472280.1_Missense_Mutation_p.E619K|MECOM_ENST00000264674.3_Missense_Mutation_p.E683K|MECOM_ENST00000468789.1_Missense_Mutation_p.E618K|MECOM_ENST00000494292.1_Missense_Mutation_p.E806K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	27							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GGTCTTGATTCGACGTTGCTT	0.473000													6	55					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157659643	157659643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157659643G>A	ENST00000368184.3	-	10	2046	c.1755C>T	c.(1753-1755)ctC>ctT	p.L585L	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Silent_p.L585L	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	585						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CAGCAAGGACGAGGATGCTGA	0.567000													30	49					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	120373013	120373013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:120373013C>T	ENST00000331113.4	+	2	2137	c.1172C>T	c.(1171-1173)tCg>tTg	p.S391L		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	391					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TCTATCTGTTCGCTGAGTGGG	0.418000													25	74					0	0	1	0	0
ASPG	374569	broad.mit.edu	37	14	104575594	104575594	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104575594G>A	ENST00000551177.1	+	13	1554	c.1462G>A	c.(1462-1464)Gaa>Aaa	p.E488K	ASPG_ENST00000546892.2_Missense_Mutation_p.E488K|ASPG_ENST00000455920.2_Missense_Mutation_p.E488K	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	488					lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						GTTGCTGCGGGAAGCCGGGGC	0.652000													9	28					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186559240	186559240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186559240C>T	ENST00000393528.3	-	12	1636	c.899G>A	c.(898-900)gGa>gAa	p.G300E	SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000431808.1_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000418609.1_Intron|SORBS2_ENST00000355634.5_Intron|SORBS2_ENST00000284776.7_Intron|SORBS2_ENST00000319471.9_Intron	NM_003603.5	NP_003594.3	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	228						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TACCGGGCGTCCAAACTCCAG	0.373000													23	152					0	0	1	0	0
PELI2	57161	broad.mit.edu	37	14	56763866	56763866	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:56763866C>T	ENST00000267460.4	+	6	1531	c.1245C>T	c.(1243-1245)ttC>ttT	p.F415F		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	415					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						AATTAATTTTCCAAGGTCCAA	0.433000													4	25					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74623563	74623563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74623563G>A	ENST00000321288.5	+	17	2306	c.2306G>A	c.(2305-2307)cGg>cAg	p.R769Q	CCDC33_ENST00000268082.4_Missense_Mutation_p.R159Q|CCDC33_ENST00000558821.1_Missense_Mutation_p.R159Q|CCDC33_ENST00000398814.3_Missense_Mutation_p.R566Q			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	769							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AAGATGGAGCGGGTGCTGGAG	0.642000													10	57					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232581315	232581315	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:232581315G>A	ENST00000366630.1	-	10	3671	c.3313C>T	c.(3313-3315)Cga>Tga	p.R1105*	SIPA1L2_ENST00000262861.4_Nonsense_Mutation_p.R1105*|SIPA1L2_ENST00000308942.4_Nonsense_Mutation_p.R179*			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1105					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GAGGTGCTTCGAGGAATGGCA	0.637000													16	54					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45402903	45402903	+	Silent	SNP	G	G	A	rs144183694	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45402903G>A	ENST00000389039.6	-	8	1273	c.888C>T	c.(886-888)atC>atT	p.I296I	DUOX2_ENST00000603300.1_Silent_p.I296I			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	296	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CATACACAGCGATGTTCTGAG	0.607000													13	35					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110493734	110493734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110493734C>T	ENST00000378402.5	+	56	9504	c.9400C>T	c.(9400-9402)Cat>Tat	p.H3134Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3134	G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TAGAGGAAATCATACTACACA	0.398000										HNSCC(38;0.096)			5	15					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180048704	180048704	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180048704G>A	ENST00000261937.6	-	13	1936	c.1858C>T	c.(1858-1860)Ctg>Ttg	p.L620L	FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000393347.3_Silent_p.L620L|FLT4_ENST00000502649.1_Silent_p.L620L	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	620	Ig-like C2-type 6.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGGCGGCCAGAGGGGTGGCG	0.682000													7	32					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468962	56468962	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:56468962G>A	ENST00000288221.6	-	2	329	c.74C>T	c.(73-75)cCt>cTt	p.P25L		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	25						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GCCCAAACGAGGAGACCTTGG	0.488000													19	52					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520004	131520004	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131520004C>T	ENST00000423981.1	+	2	469	c.359C>T	c.(358-360)tCc>tTc	p.S120F	AMER3_ENST00000321420.4_Missense_Mutation_p.S120F	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		TTCCCGGGCTCCCCGGGCAGC	0.642000													12	23					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94650958	94650958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94650958G>A	ENST00000260526.6	-	17	2042	c.1860C>T	c.(1858-1860)tcC>tcT	p.S620S	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	620					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ATTTCGTGGGGGATCTCAATT	0.398000													37	82					0	0	1	0	0
TNFSF18	8995	broad.mit.edu	37	1	173010692	173010692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173010692G>A	ENST00000404377.3	-	3	415	c.415C>T	c.(415-417)Ctg>Ttg	p.L139L	TNFSF18_ENST00000239468.2_Silent_p.L117L|RP1-15D23.2_ENST00000432694.1_RNA	NM_005092.3	NP_005083.2	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily, member 18	139					anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	9						TTTTTATACAGCCGCACCTCA	0.383000													23	81					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247063417	247063417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247063417G>A	ENST00000366508.1	-	10	1623	c.1487C>T	c.(1486-1488)cCt>cTt	p.P496L	AHCTF1_ENST00000326225.3_Missense_Mutation_p.P470L|AHCTF1_ENST00000391829.2_Missense_Mutation_p.P461L			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	461	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TGGATATGAAGGAGGGACTCC	0.368000													61	187					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72156856	72156856	+	Nonsense_Mutation	SNP	G	G	A	rs140352254		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72156856G>A	ENST00000537465.1	-	19	2898	c.2740C>T	c.(2740-2742)Cga>Tga	p.R914*	PMFBP1_ENST00000355636.6_Nonsense_Mutation_p.R764*|PMFBP1_ENST00000537792.1_Nonsense_Mutation_p.R75*|PMFBP1_ENST00000237353.10_Nonsense_Mutation_p.R909*			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	914										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				ACCTGCTCTCGGAGCTGGTTT	0.532000													14	33					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370490	240370490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240370490G>A	ENST00000319653.9	+	5	2608	c.2378G>A	c.(2377-2379)cGa>cAa	p.R793Q		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	793	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCTCCAAGGCGAATATCAGTC	0.577000													20	78					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688487	26688487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26688487C>T	ENST00000529632.2	+	2	406	c.210C>T	c.(208-210)ccC>ccT	p.P70P	SEZ6L_ENST00000343706.4_Silent_p.P70P|SEZ6L_ENST00000360929.3_Silent_p.P70P|SEZ6L_ENST00000404234.3_Silent_p.P70P|SEZ6L_ENST00000248933.6_Silent_p.P70P|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000403121.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	70						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						TAACAGCGCCCCCCAGTTCCT	0.632000													8	42					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9364963	9364963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9364963C>T	ENST00000378501.2	+	11	984	c.969C>T	c.(967-969)ttC>ttT	p.F323F	PLCB4_ENST00000414679.2_Silent_p.F323F|PLCB4_ENST00000378493.1_Silent_p.F323F|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Silent_p.F323F|PLCB4_ENST00000378473.3_Silent_p.F323F|PLCB4_ENST00000334005.3_Silent_p.F323F	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	323	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CTCACTACTTCATCAGTTCTT	0.468000													36	94					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43420354	43420354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43420354C>T	ENST00000601833.1	-	2	1420	c.137G>A	c.(136-138)gGa>gAa	p.G46E	PSG6_ENST00000292125.2_Missense_Mutation_p.G117E|PSG6_ENST00000402603.4_Missense_Mutation_p.G117E|PSG6_ENST00000187910.2_Missense_Mutation_p.G117E					pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				GGTGTAGGATCCTGCATCCTC	0.468000													156	310					0	0	1	0	0
ZNF326	284695	broad.mit.edu	37	1	90493234	90493234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:90493234C>T	ENST00000340281.4	+	12	1866	c.1723C>T	c.(1723-1725)Cct>Tct	p.P575S	ZNF326_ENST00000370447.2_Missense_Mutation_p.P486S|ZNF326_ENST00000455342.2_Missense_Mutation_p.P369S	NM_182976.2	NP_892021.1	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326	575	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(7)|ovary(1)	25		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TGCTGACTTCCCTGTTGAGCA	0.398000													26	51					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55909079	55909079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55909079G>A	ENST00000290567.9	-	1	176	c.55C>T	c.(55-57)Ctt>Ttt	p.L19F	CES5A_ENST00000521992.1_Intron|CES5A_ENST00000319165.9_Missense_Mutation_p.L19F|CES5A_ENST00000541580.1_Intron|CES5A_ENST00000520435.1_Missense_Mutation_p.L19F|CES5A_ENST00000518005.1_Intron	NM_001143685.1	NP_001137157.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	19						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GGGGCTGCAAGGACCCAGATA	0.532000													29	115					0	0	1	0	0
AOC1	26	broad.mit.edu	37	7	150553935	150553935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150553935G>A	ENST00000493429.1	+	4	961	c.377G>A	c.(376-378)cGa>cAa	p.R126Q	AOC1_ENST00000416793.2_Missense_Mutation_p.R126Q|AOC1_ENST00000467291.1_Missense_Mutation_p.R126Q|AOC1_ENST00000360937.4_Missense_Mutation_p.R126Q					amine oxidase, copper containing 1																		TGCTACATGCGAGCACTGTCC	0.637000													36	84					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48609816	48609816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48609816C>T	ENST00000328333.8	-	89	7082	c.6975G>A	c.(6973-6975)gaG>gaA	p.E2325E	COL7A1_ENST00000454817.1_Silent_p.E2293E	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2325	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TACTTACCGGCTCACCCACCA	0.597000													36	84					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	97987291	97987291	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97987291G>A	ENST00000224337.5	-	5	377	c.236C>T	c.(235-237)tCg>tTg	p.S79L	BLNK_ENST00000413476.2_Missense_Mutation_p.S79L|BLNK_ENST00000427367.2_Missense_Mutation_p.S79L|BLNK_ENST00000371176.2_Missense_Mutation_p.S79L	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	79					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CTCTGAGTCCGAGTGCTCATC	0.592000													16	130					0	0	1	0	0
YOD1	55432	broad.mit.edu	37	1	207222587	207222587	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207222587G>A	ENST00000367084.1	-	4	897	c.693C>T	c.(691-693)ttC>ttT	p.F231F	YOD1_ENST00000391927.1_Silent_p.F231F|YOD1_ENST00000315927.4_Silent_p.F275F	NM_001276320.1	NP_001263249.1	Q5VVQ6	OTU1_HUMAN	YOD1 deubiquitinase	275	OTU.				cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(3)	11	Prostate(682;0.19)					CTGGATCAGGGAAGTTACGCT	0.413000													74	179					0	0	1	0	0
RHBDD1	84236	broad.mit.edu	37	2	227731973	227731973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227731973C>T	ENST00000392062.2	+	5	1029	c.505C>T	c.(505-507)Cct>Tct	p.P169S	RHBDD1_ENST00000341329.3_Missense_Mutation_p.P169S	NM_001167608.1	NP_001161080.1	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	169						integral to membrane	serine-type endopeptidase activity			breast(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		TTTGGGCTTTCCTGTACCGAA	0.393000													65	203					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	131009728	131009728	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131009728C>T	ENST00000341179.7	+	17	1948	c.1856C>T	c.(1855-1857)tCc>tTc	p.S619F	DNM1_ENST00000475805.1_Missense_Mutation_p.S619F|DNM1_ENST00000486160.1_Missense_Mutation_p.S619F|DNM1_ENST00000372923.3_Missense_Mutation_p.S619F|DNM1_ENST00000393594.3_Missense_Mutation_p.S619F	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	619	PH.				receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						TGGAAGGCCTCCTTCCTGAGG	0.607000													6	21					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29295578	29295578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29295578G>A	ENST00000331664.5	-	1	1549	c.1550C>T	c.(1549-1551)tCa>tTa	p.S517L		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	517					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						GTCAGCAGGTGAAGATTGTGG	0.542000													56	94					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634006	70634006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70634006C>T	ENST00000381269.2	-	2	1887	c.1134G>A	c.(1132-1134)aaG>aaA	p.K378K	SLC8A3_ENST00000534137.1_Silent_p.K378K|SLC8A3_ENST00000528359.1_Silent_p.K378K|SLC8A3_ENST00000356921.2_Silent_p.K378K|SLC8A3_ENST00000357887.3_Silent_p.K378K	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	378					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TGGAGGCCTTCTTGGCTTGTT	0.517000													54	106					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113288760	113288760	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113288760G>A	ENST00000362072.3	-	3	728	c.384C>T	c.(382-384)atC>atT	p.I128I	DRD2_ENST00000544518.1_Silent_p.I127I|DRD2_ENST00000542968.1_Silent_p.I128I|DRD2_ENST00000346454.3_Silent_p.I128I|DRD2_ENST00000538967.1_Silent_p.I128I|DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000355319.2_Silent_p.I128I	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	128					activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	TGTCGATGCTGATGGCACACA	0.552000													9	41					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91549184	91549184	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:91549184C>T	ENST00000509176.1	+	6	2021	c.1733C>T	c.(1732-1734)tCc>tTc	p.S578F	CCSER1_ENST00000432775.2_Missense_Mutation_p.S578F|CCSER1_ENST00000333691.8_Missense_Mutation_p.S578F	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		AGGAATCTTTCCCTGAAATTA	0.408000													18	48					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4648002	4648002	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4648002G>A	ENST00000433935.1	+	11	1823	c.1766G>A	c.(1765-1767)aGg>aAg	p.R589K	ZMYND15_ENST00000573751.2_Missense_Mutation_p.R589K|ZMYND15_ENST00000592813.1_Missense_Mutation_p.R550K|ZMYND15_ENST00000269289.6_Missense_Mutation_p.R550K	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	550							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						GGGGGCCGCAGGGACCTGCAG	0.617000													29	40					0	0	1	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200813990	200813990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200813990C>T	ENST00000358823.2	+	8	1372	c.1102C>T	c.(1102-1104)Cct>Tct	p.P368S	CAMSAP2_ENST00000236925.4_Missense_Mutation_p.P379S|CAMSAP2_ENST00000413307.2_Missense_Mutation_p.P368S	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	379						cytoplasm|microtubule	protein binding										TTCTGACTTCCCTTCAAGGTA	0.279000													11	68					0	0	1	0	0
DNAJA3	9093	broad.mit.edu	37	16	4491432	4491432	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4491432C>T	ENST00000262375.6	+	4	563	c.486C>T	c.(484-486)ttC>ttT	p.F162F	DNAJA3_ENST00000431375.2_Intron|DNAJA3_ENST00000572139.1_3'UTR|DNAJA3_ENST00000355296.4_Silent_p.F162F	NM_005147.5	NP_005138.3	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	162					activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|upper_aerodigestive_tract(2)	15						CTGCAGGCTTCGATCCTGGGG	0.577000													5	51					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085504	9085504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9085504C>T	ENST00000397910.4	-	1	6514	c.6311G>A	c.(6310-6312)aGa>aAa	p.R2104K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2104	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCTGGATTTCTTTGCTTAGC	0.502000													50	152					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13125237	13125237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:13125237G>A	ENST00000319217.7	-	35	5032	c.4785C>T	c.(4783-4785)tcC>tcT	p.S1595S	MPDZ_ENST00000541718.1_Silent_p.S1595S|MPDZ_ENST00000447879.1_Silent_p.S1562S|MPDZ_ENST00000381015.4_Silent_p.S1595S|MPDZ_ENST00000541093.1_5'UTR|MPDZ_ENST00000536827.1_Silent_p.S1562S|MPDZ_ENST00000538841.1_Silent_p.S454S|MPDZ_ENST00000381022.2_Silent_p.S1595S|MPDZ_ENST00000546205.1_Silent_p.S1609S	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1595					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		CCGGTTCTGGGGAGCCAGACT	0.547000													24	47					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155160	12155160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12155160C>T	ENST00000602107.1	-	5	1196	c.1197G>A	c.(1195-1197)aaG>aaA	p.K399K	CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591898.1_RNA|CTD-2006C1.2_ENST00000591838.1_RNA|ZNF878_ENST00000547628.1_Silent_p.K352K|CTD-2006C1.2_ENST00000476474.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TTCGAAGATCCTTGACAAAAC	0.373000													7	85					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96163702	96163702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:96163702C>T	ENST00000453304.1	-	7	1334	c.986G>A	c.(985-987)gGa>gAa	p.G329E	UNC5C_ENST00000506749.1_Missense_Mutation_p.G329E	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	329	TSP type-1 2.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GCACTCAGTTCCACAAGTAGA	0.597000													7	17					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11835445	11835445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11835445C>T	ENST00000262442.3	+	64	12288	c.12220C>T	c.(12220-12222)Cgc>Tgc	p.R4074C	DNAH9_ENST00000454412.2_Missense_Mutation_p.R3998C|DNAH9_ENST00000396001.2_Missense_Mutation_p.R386C	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4074	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGGATGGAATCGCTCATACCC	0.502000													49	63					0	0	1	0	0
MAN2A2	4122	broad.mit.edu	37	15	91449187	91449187	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91449187C>T	ENST00000360468.3	+	4	666	c.648C>T	c.(646-648)gtC>gtT	p.V216V	MAN2A2_ENST00000559717.1_Silent_p.V216V	NM_006122.2	NP_006113.2	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	216					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GGGCAGAGGTCTCCTTCTTCG	0.577000													17	40					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8130986	8130986	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8130986G>A	ENST00000600128.1	-	64	8661	c.8247C>T	c.(8245-8247)ttC>ttT	p.F2749F	FBN3_ENST00000601739.1_Silent_p.F2749F|FBN3_ENST00000270509.2_Silent_p.F2749F			Q75N90	FBN3_HUMAN	fibrillin 3	2749						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GCATGCGAAAGAAACCTTGCT	0.692000													31	101					0	0	1	0	0
RFPL4B	442247	broad.mit.edu	37	6	112671667	112671667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:112671667G>A	ENST00000441065.2	+	3	1069	c.757G>A	c.(757-759)Ggg>Agg	p.G253R		NM_001013734.2	NP_001013756.2	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	253	B30.2/SPRY.						zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	14		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CTTGGGAGAAGGGGAGAGTGG	0.448000													18	44					0	0	1	0	0
SLC1A1	6505	broad.mit.edu	37	9	4576603	4576603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:4576603G>A	ENST00000262352.3	+	10	1269	c.1033G>A	c.(1033-1035)Gaa>Aaa	p.E345K		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	345					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	CCGCTGTGCTGAAGAAAATAA	0.478000													10	92					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621171	179621171	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179621171G>A	ENST00000589042.1	-	46	11256	c.11032C>T	c.(11032-11034)Caa>Taa	p.Q3678*	TTN_ENST00000342992.6_Intron|TTN_ENST00000360870.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.Q3507*|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3363	Ig-like 22.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAGGAATTGAGCCGTGTCA	0.448000													13	38					0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135078869	135078869	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:135078869G>A	ENST00000428680.2	-	10	1698	c.1419C>T	c.(1417-1419)ttC>ttT	p.F473F	CNOT4_ENST00000361528.4_Silent_p.F473F|CNOT4_ENST00000315544.5_Silent_p.F476F|CNOT4_ENST00000423368.2_Silent_p.F476F|CNOT4_ENST00000451834.1_Silent_p.F473F|CNOT4_ENST00000356162.4_Intron|CNOT4_ENST00000414802.1_Intron|CNOT4_ENST00000541284.1_Silent_p.F476F	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	476					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						GAAATTGAGGGAACCTCTGGG	0.507000													40	90					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103484	52103484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52103484C>T	ENST00000361781.2	-	7	1350	c.391G>A	c.(391-393)Gag>Aag	p.E131K	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Missense_Mutation_p.E131K	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	137					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity	p.E131*(1)		endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						TTGCCCCACTCCATGGGGTAC	0.488000													38	72					0	0	1	0	0
PIGU	128869	broad.mit.edu	37	20	33162998	33162998	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33162998G>A	ENST00000374820.2	-	10	1064	c.1044C>T	c.(1042-1044)ctC>ctT	p.L348L	PIGU_ENST00000452740.2_Silent_p.L368L			Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class U	368					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						GGACAGGGAAGAGCAGGGAAC	0.493000													8	66					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370313	240370313	+	Missense_Mutation	SNP	G	G	A	rs140911005		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240370313G>A	ENST00000319653.9	+	5	2431	c.2201G>A	c.(2200-2202)cGg>cAg	p.R734Q		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	734					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAGGAAGTACGGCATCATAGG	0.557000													10	40					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22132409	22132409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:22132409G>A	ENST00000389398.5	+	13	1333	c.1237G>A	c.(1237-1239)Gtc>Atc	p.V413I	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	413						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		GTGGCTTAAGGTCAATGGTCT	0.512000													10	76					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650650	121650650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:121650650C>T	ENST00000393386.2	+	12	1961	c.1550C>T	c.(1549-1551)tCc>tTc	p.S517F	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.S517F	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	517					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AAAGATATTTCCTTGACTTCT	0.408000													31	80					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717239	13717239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13717239C>T	ENST00000279593.3	-	13	3142	c.2933G>A	c.(2932-2934)aGc>aAc	p.S978N		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	978					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTACACGTTGCTGTCCTTCAG	0.542000													14	76					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431664	140431664	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140431664G>A	ENST00000306549.3	+	1	686	c.609G>A	c.(607-609)gaG>gaA	p.E203E		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		203	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGACCGAGAGGAGCAGCCTG	0.582000													5	32					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16001112	16001112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16001112C>T	ENST00000350896.3	-	8	1185	c.988G>A	c.(988-990)Gga>Aga	p.G330R	MSR1_ENST00000445506.2_Missense_Mutation_p.G348R|MSR1_ENST00000536385.1_Missense_Mutation_p.G104R|MSR1_ENST00000381998.4_Missense_Mutation_p.G330R|MSR1_ENST00000262101.5_Missense_Mutation_p.G330R|MSR1_ENST00000355282.2_Missense_Mutation_p.G330R	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	357	Collagen-like.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCTTTTGGTCCAGAATTTCCT	0.328000													18	56					0	0	1	0	0
MIEF2	125170	broad.mit.edu	37	17	18167217	18167217	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18167217C>T	ENST00000395704.4	+	4	578	c.430C>T	c.(430-432)Ccc>Tcc	p.P144S	SMCR7_ENST00000395706.2_Silent_p.F179F|SMCR7_ENST00000577216.1_3'UTR|SMCR7_ENST00000323019.4_Silent_p.F168F			Q96C03	SMCR7_HUMAN		25						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(4)	9	all_neural(463;0.228)					GGAGCAAGTTCCCGGAACTGC	0.672000													13	12					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286946	152286946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152286946C>T	ENST00000368799.1	-	3	451	c.416G>A	c.(415-417)gGa>gAa	p.G139E	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	139					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGGATCTTCCCTTATTCCC	0.353000									Ichthyosis				35	133					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71665544	71665544	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71665544G>A	ENST00000356340.3	+	16	1453	c.915_splice	c.e16-1	p.G306_splice	COL13A1_ENST00000398968.3_Splice_Site_p.G287_splice|COL13A1_ENST00000520133.1_Splice_Site_p.G255_splice|COL13A1_ENST00000398966.3_Splice_Site_p.G284_splice|COL13A1_ENST00000398969.3_Splice_Site_p.G249_splice|COL13A1_ENST00000398974.3_Splice_Site_p.G294_splice|COL13A1_ENST00000398972.3_Splice_Site_p.G306_splice|COL13A1_ENST00000398973.3_Splice_Site_p.G306_splice|COL13A1_ENST00000398971.3_Splice_Site_p.G306_splice|COL13A1_ENST00000520267.1_Splice_Site_p.G249_splice|COL13A1_ENST00000398964.3_Splice_Site_p.G277_splice|COL13A1_ENST00000357811.3_Splice_Site_p.G284_splice|COL13A1_ENST00000354547.3_Splice_Site_p.G284_splice|COL13A1_ENST00000517713.1_Splice_Site_p.G284_splice|COL13A1_ENST00000522165.1_Splice_Site_p.G287_splice|COL13A1_ENST00000398978.3_Splice_Site_p.G306_splice			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	306	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	TTTTCCCAGGGAGACCCAGGG	0.542000													9	25					0	0	1	0	0
RELA	5970	broad.mit.edu	37	11	65423223	65423223	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65423223G>A	ENST00000525693.1	-	10	1031	c.969C>T	c.(967-969)gaC>gaT	p.D323D	RELA_ENST00000406246.3_Silent_p.D323D|RELA_ENST00000308639.9_Silent_p.D320D			Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	323					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						GAGGCCGGGGGTCGGTGGGTC	0.627000													26	60					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45941801	45941801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45941801G>A	ENST00000323084.4	-	9	1596	c.1531C>T	c.(1531-1533)Ctc>Ttc	p.L511F	TSPEAR_ENST00000397916.1_Missense_Mutation_p.L443F|C21orf90_ENST00000465978.1_Intron	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	511					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						GAGCCCAGGAGTCGGATGTAG	0.632000													23	65					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798094	55798094	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55798094C>T	ENST00000313555.1	+	1	200	c.200C>T	c.(199-201)tCt>tTt	p.S67F		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					AGCAACTTATCTTTCTTAGAC	0.343000													25	53					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135042402	135042402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135042402G>A	ENST00000393229.3	+	2	960	c.184G>A	c.(184-186)Gga>Aga	p.G62R	NTNG2_ENST00000360670.3_Missense_Mutation_p.G62R|NTNG2_ENST00000393228.4_Missense_Mutation_p.G62R|NTNG2_ENST00000372179.3_Missense_Mutation_p.G62R	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	62	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		CATCACATGTGGAGACCCCCC	0.587000													4	35					0	0	1	0	0
AIRE	326	broad.mit.edu	37	21	45712900	45712900	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45712900G>A	ENST00000291582.5	+	10	1247	c.1120G>A	c.(1120-1122)Gga>Aga	p.G374R	AIRE_ENST00000355347.4_Missense_Mutation_p.G167R|AIRE_ENST00000329347.4_Missense_Mutation_p.G167R	NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	374					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		TAGGTCGGCGGGAGAGGAGGT	0.682000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				10	65					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179621192	179621192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179621192C>T	ENST00000444136.1	+	13	2270	c.2020C>T	c.(2020-2022)Cct>Tct	p.P674S	TDRD5_ENST00000367614.1_Missense_Mutation_p.P674S|TDRD5_ENST00000294848.8_Missense_Mutation_p.P674S	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	674					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						TGAGCTCAACCCTTTAGCTTT	0.398000													9	100					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49440321	49440321	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49440321C>T	ENST00000374201.3	-	10	1307	c.1005G>A	c.(1003-1005)ggG>ggA	p.G335G	FRMPD2_ENST00000407470.4_Silent_p.G304G|FRMPD2_ENST00000305531.3_Silent_p.G311G	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	335					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		AATAGGATTTCCCTTTTTTGG	0.423000													12	21					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48614120	48614120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48614120G>A	ENST00000328333.8	-	67	5796	c.5689C>T	c.(5689-5691)Cct>Tct	p.P1897S	COL7A1_ENST00000454817.1_Intron	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1897	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity	p.P1897T(1)		NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGCCAGGAGGGCCCACTGGC	0.617000													4	8					0	0	1	0	0
KIFC2	90990	broad.mit.edu	37	8	145692663	145692663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145692663G>A	ENST00000301332.2	+	4	785	c.408G>A	c.(406-408)ggG>ggA	p.G136G		NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	136					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCCCCAGGGGGAGGCAGGCCC	0.612000											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	66					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41099087	41099087	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41099087G>A	ENST00000204005.9	+	1	16	c.16_splice	c.e1+1	p.A6_splice	LTBP4_ENST00000545697.1_5'UTR|LTBP4_ENST00000602240.1_3'UTR	NM_003573.2	NP_003564.2	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	0					growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGACGTAAAAGGTGAGTGCCT	0.428000													18	49					0	0	1	0	0
DPY19L3	147991	broad.mit.edu	37	19	32954811	32954811	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:32954811C>T	ENST00000342179.5	+	14	1697	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	DPY19L3_ENST00000586987.1_Silent_p.F494F|DPY19L3_ENST00000590651.1_3'UTR|DPY19L3_ENST00000392250.2_Silent_p.F494F	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	494						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					TGTGTGTGTTCGCATCATTCG	0.443000													84	196					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101755566	101755566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101755566G>A	ENST00000506729.1	-	8	1607	c.1436C>T	c.(1435-1437)cCa>cTa	p.P479L	SLCO6A1_ENST00000379810.1_Intron|SLCO6A1_ENST00000513675.1_Intron|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.P417L|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.P479L			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	479						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AAATTGCACTGGATTACAGCG	0.323000													49	130					0	0	1	0	0
DENND6B	414918	broad.mit.edu	37	22	50757412	50757412	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50757412G>A	ENST00000413817.2	-	2	269	c.198C>T	c.(196-198)ttC>ttT	p.F66F		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		CTGTGAGCCGGAAGTCGTTCG	0.577000													10	7					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94053657	94053657	+	Missense_Mutation	SNP	G	G	A	rs72658200		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94053657G>A	ENST00000297268.6	+	41	3046	c.2575G>A	c.(2575-2577)Ggc>Agc	p.G859S		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	859					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGGACCTCCTGGCACTCCAGG	0.493000										HNSCC(75;0.22)			23	71					0	0	1	0	0
TMEM194A	23306	broad.mit.edu	37	12	57453726	57453726	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57453726G>A	ENST00000300128.4	-	9	1294	c.1271C>T	c.(1270-1272)tCc>tTc	p.S424F	TMEM194A_ENST00000379391.3_Missense_Mutation_p.S351F	NM_001130963.1	NP_001124435.1	O14524	T194A_HUMAN	transmembrane protein 194A	424						integral to membrane				endometrium(3)|large_intestine(3)|lung(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CTCCTCAGAGGATGCTTCCTC	0.473000													19	36					0	0	1	0	0
LRRC3	81543	broad.mit.edu	37	21	45877193	45877193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45877193C>T	ENST00000291592.4	+	2	983	c.666C>T	c.(664-666)gtC>gtT	p.V222V		NM_030891.3	NP_112153.1	Q9BY71	LRRC3_HUMAN	leucine rich repeat containing 3	222						integral to membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		TCGCCTACGTCGTGTACTATG	0.657000													32	80					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149853837	149853837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:149853837G>A	ENST00000435030.1	+	18	2451	c.2083G>A	c.(2083-2085)Gat>Aat	p.D695N	KIF5C_ENST00000414838.2_Missense_Mutation_p.D600N|KIF5C_ENST00000397413.1_Missense_Mutation_p.D463N|KIF5C_ENST00000464066.1_3'UTR			O60282	KIF5C_HUMAN	kinesin family member 5C	695					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		GCGGTTGCAGGATGCTGAAGA	0.423000													10	31					0	0	1	0	0
TRAT1	50852	broad.mit.edu	37	3	108565964	108565964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108565964G>A	ENST00000295756.6	+	4	432	c.202G>A	c.(202-204)Gat>Aat	p.D68N	TRAT1_ENST00000493604.1_3'UTR|TRAT1_ENST00000426646.1_Missense_Mutation_p.D31N	NM_016388.2	NP_057472.2	Q6PIZ9	TRAT1_HUMAN	T cell receptor associated transmembrane adaptor 1	68					cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(3)	28						TAACTTAGATGATATGATTTC	0.259000													17	80					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162307203	162307203	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:162307203G>A	ENST00000306100.5	-	16	2676	c.2240C>T	c.(2239-2241)tCc>tTc	p.S747F	FSTL5_ENST00000536695.1_Missense_Mutation_p.S746F|FSTL5_ENST00000427802.2_Missense_Mutation_p.S737F|RP11-234O6.2_ENST00000508189.1_RNA|FSTL5_ENST00000379164.4_Missense_Mutation_p.S746F	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	747						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCAGTAAAGGATGGTTGAAA	0.413000													25	64					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129168726	129168726	+	Silent	SNP	C	C	T	rs139138308		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129168726C>T	ENST00000296266.3	+	2	246	c.54C>T	c.(52-54)atC>atT	p.I18I	IFT122_ENST00000347300.2_Silent_p.I18I|IFT122_ENST00000431818.2_5'UTR|IFT122_ENST00000349441.2_Silent_p.I18I|IFT122_ENST00000440957.2_5'UTR|IFT122_ENST00000348417.2_Silent_p.I18I|IFT122_ENST00000507564.1_Silent_p.I18I|IFT122_ENST00000504021.1_Silent_p.I18I	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	18					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TAAATGACATCGCATTTAAGC	0.393000													40	112					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17462284	17462284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:17462284G>A	ENST00000262545.2	+	12	1801	c.1486G>A	c.(1486-1488)Ggg>Agg	p.G496R	PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000536609.1_Missense_Mutation_p.G461R|PCSK2_ENST00000377899.1_Missense_Mutation_p.G477R	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	496					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGCCTGTGAGGGGAAGGAAAA	0.522000													24	86					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7711159	7711159	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7711159G>A	ENST00000441779.2	+	16	1451	c.1414G>A	c.(1414-1416)Gag>Aag	p.E472K	STXBP2_ENST00000414284.2_Missense_Mutation_p.E458K|STXBP2_ENST00000221283.5_Missense_Mutation_p.E461K|STXBP2_ENST00000602355.1_5'UTR	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	461					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						CAGCCGGCTGGAGCCGAGAGA	0.672000													3	5					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31374337	31374337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31374337C>T	ENST00000268296.4	+	13	1562	c.1441C>T	c.(1441-1443)Ccc>Tcc	p.P481S	ITGAX_ENST00000562522.1_Missense_Mutation_p.P481S	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	481					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CATCGGGGCCCCCCATTACTA	0.677000													18	85					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113562887	113562887	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113562887C>T	ENST00000416899.2	+	13	2331	c.2205C>T	c.(2203-2205)gaC>gaT	p.D735D	MUSK_ENST00000189978.5_Silent_p.D743D|MUSK_ENST00000374448.4_Silent_p.D743D			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	743	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						AAATTGCCGACTTTGGCCTCT	0.483000													67	161					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56235370	56235370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56235370G>A	ENST00000332836.2	-	4	2162	c.2135C>T	c.(2134-2136)cCa>cTa	p.P712L		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	712						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTTGCACATTGGATGTTTCAG	0.478000													47	68					0	0	1	0	0
FRRS1L	23732	broad.mit.edu	37	9	111903821	111903821	+	Missense_Mutation	SNP	G	G	A	rs143745415		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111903821G>A	ENST00000374581.3	-	4	663	c.664C>T	c.(664-666)Cgc>Tgc	p.R222C		NM_014334.2	NP_055149.2	Q9P0K9	CI004_HUMAN	ferric-chelate reductase 1-like	222	DOMON.					integral to membrane											TGCTGTATGCGGACCCTGCCA	0.448000													48	60					0	0	1	0	0
HSD17B3	3293	broad.mit.edu	37	9	99003048	99003048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:99003048C>T	ENST00000375263.3	-	10	861	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	HSD17B3_ENST00000375262.2_Intron|HSD17B3_ENST00000464104.1_5'UTR	NM_000197.1	NP_000188.1	P37058	DHB3_HUMAN	hydroxysteroid (17-beta) dehydrogenase 3	272					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	ACCAAGATTTCATGGGCAAGG	0.473000													21	89					0	0	1	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114107626	114107626	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:114107626G>A	ENST00000375418.3	-	1	213	c.127C>T	c.(127-129)Ctg>Ttg	p.L43L		NM_138430.3	NP_612439.2	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	43					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			AGGTGGTCCAGGCCCCCGGAA	0.612000													26	71					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862327	14862327	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14862327C>T	ENST00000285046.5	+	1	1859	c.1749C>T	c.(1747-1749)ctC>ctT	p.L583L	FGD5_ENST00000543601.1_Silent_p.L342L	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	583					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding	p.L342L(1)|p.L583L(1)		NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						AGGACAATCTCTCTCTGTCGT	0.562000													17	59					0	0	1	0	0
BOP1	23246	broad.mit.edu	37	8	145512850	145512850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145512850C>T	ENST00000307404.5	-	2	264	c.235G>A	c.(235-237)Gag>Aag	p.E79K	BOP1_ENST00000529231.1_Silent_p.T6T	NM_015201.3	NP_056016.1	Q14137	BOP1_HUMAN	block of proliferation 1	79					cell proliferation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	nucleoplasm|PeBoW complex	protein binding			lung(1)|urinary_tract(2)	3	all_cancers(97;4.06e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;2.61e-39)|all cancers(56;1.37e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.087)			TCTCCCTCCTCGTCGCCTTCG	0.612000													25	98					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66504220	66504220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:66504220C>T	ENST00000360242.5	+	2	337	c.220C>T	c.(220-222)Cgc>Tgc	p.R74C	CCDC102B_ENST00000584156.1_Missense_Mutation_p.R74C|CCDC102B_ENST00000319445.6_Missense_Mutation_p.R74C|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000358653.5_Missense_Mutation_p.R74C	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	74										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				TGAAGAACTTCGCCTGCGGGA	0.483000													33	173					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137852557	137852557	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:137852557G>A	ENST00000409968.1	+	4	1243	c.1065G>A	c.(1063-1065)ggG>ggA	p.G355G	THSD7B_ENST00000272643.3_Silent_p.G355G|THSD7B_ENST00000543459.1_Silent_p.G214G|THSD7B_ENST00000413152.2_Silent_p.G324G					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCCGTTCAGGGAGTCTCTTGC	0.537000													30	64					0	0	1	0	0
TTC9C	283237	broad.mit.edu	37	11	62502996	62502996	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62502996C>T	ENST00000316461.4	+	2	691	c.381C>T	c.(379-381)gcC>gcT	p.A127A	TTC9C_ENST00000532583.1_Silent_p.A127A|TTC9C_ENST00000513247.2_3'UTR	NM_173810.3	NP_776171.1	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	127							binding			breast(1)|endometrium(1)|lung(2)|ovary(1)|pancreas(1)	6						ATGACCAGGCCCGCCACTACC	0.512000													15	23					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9916206	9916206	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9916206G>A	ENST00000396573.2	-	11	2392	c.2083C>T	c.(2083-2085)Cgg>Tgg	p.R695W	GRIN2A_ENST00000404927.2_Missense_Mutation_p.R695W|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R695W|GRIN2A_ENST00000330684.3_Missense_Mutation_p.R695W|GRIN2A_ENST00000396575.2_Missense_Mutation_p.R695W|GRIN2A_ENST00000535259.1_Missense_Mutation_p.R538W	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	695					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAGTTATTCCGAATGTTTCTC	0.458000													28	75					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799376	45799376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45799376G>A	ENST00000553795.1	-	4	803	c.495C>T	c.(493-495)gcC>gcT	p.A165A	OR13A1_ENST00000374401.2_Silent_p.A165A|OR13A1_ENST00000536058.1_Silent_p.A165A	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						GCAGCCACACGGCTGTGGCCA	0.597000													14	54					0	0	1	0	0
GPR21	2844	broad.mit.edu	37	9	125797634	125797634	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125797634C>T	ENST00000373642.1	+	1	829	c.789C>T	c.(787-789)atC>atT	p.I263I	RABGAP1_ENST00000373647.4_Intron|RABGAP1_ENST00000373643.5_Intron|RABGAP1_ENST00000493854.1_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	263						integral to plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						TATTTTACATCCTCTGGTTGC	0.507000													10	160					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77359766	77359766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77359766C>T	ENST00000282849.5	-	13	2447	c.2029G>A	c.(2029-2031)Gaa>Aaa	p.E677K		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	677	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AAATTACCTTCCACTTTTGTA	0.373000													10	53					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54817803	54817803	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54817803C>T	ENST00000545554.1	+	24	5514	c.5514C>T	c.(5512-5514)gtC>gtT	p.V1838V	UNC13C_ENST00000537900.1_Silent_p.V1836V|UNC13C_ENST00000260323.11_Silent_p.V1838V			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1838					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TCAGTGGGGTCCTGGATGAGC	0.388000													5	32					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4645066	4645066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4645066C>T	ENST00000433935.1	+	3	839	c.782C>T	c.(781-783)cCc>cTc	p.P261L	ZMYND15_ENST00000573751.2_Missense_Mutation_p.P261L|ZMYND15_ENST00000592813.1_Missense_Mutation_p.P261L|ZMYND15_ENST00000269289.6_Missense_Mutation_p.P261L	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	261							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						TCTGGGGATCCCCGAAAGCCC	0.622000													19	20					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106865267	106865267	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106865267C>T	ENST00000369701.3	+	7	1433	c.1206C>T	c.(1204-1206)ttC>ttT	p.F402F		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	402						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AATATATCTTCATTCAGGTGA	0.502000													35	128					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1115683	1115683	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1115683C>T	ENST00000379290.1	+	6	642	c.469C>T	c.(469-471)Ccc>Tcc	p.P157S	TTLL10_ENST00000379289.1_Missense_Mutation_p.P157S|TTLL10_ENST00000379288.3_Missense_Mutation_p.P84S			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	157	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCGGCCGGGGCCCTTCTTCTA	0.697000													4	12					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64527202	64527202	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64527202C>T	ENST00000498707.1	-	34	5634	c.5292_splice	c.e34+1	p.K1764_splice	ADAMTS9_ENST00000295903.4_Splice_Site_p.K1736_splice	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1764	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGACATTCACCTTCAGAAGCT	0.398000													36	112					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206331107	206331107	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206331107G>A	ENST00000360218.2	+	8	1075	c.971G>A	c.(970-972)gGg>gAg	p.G324E	CTSE_ENST00000361052.3_Silent_p.G376G|CTSE_ENST00000358184.2_Silent_p.G371G|CTSE_ENST00000432969.2_Missense_Mutation_p.G249E	NM_148964.2	NP_683865.1	P14091	CATE_HUMAN	cathepsin E	152					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GGATCCTGGGGGATGTCTTCA	0.562000													55	129					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97485045	97485045	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:97485045C>T	ENST00000376705.2	+	2	1033	c.1009C>T	c.(1009-1011)Ctg>Ttg	p.L337L		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	337						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					AAACACCATCCTGTTGCAGAG	0.488000													32	94					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180489	124180489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124180489G>A	ENST00000357821.2	-	1	244	c.174C>T	c.(172-174)ccC>ccT	p.P58P		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AATAGTACATGGGGGTGTGAA	0.483000													18	73					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150881820	150881820	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:150881820C>T	ENST00000474524.1	+	8	1286	c.1248C>T	c.(1246-1248)ttC>ttT	p.F416F	MED12L_ENST00000422248.2_Silent_p.F416F|MED12L_ENST00000309237.4_Silent_p.F416F|MED12L_ENST00000273432.4_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	416					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACACGGCTTTCAATCAGCAGG	0.507000													33	75					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902441	40902441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40902441C>T	ENST00000324001.7	-	7	2088	c.1818G>A	c.(1816-1818)ccG>ccA	p.P606P	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	606	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGGGCACCTTCGGGAGTTGCA	0.537000													84	209					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43788217	43788217	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43788217G>A	ENST00000261488.6	-	17	2418	c.1841C>T	c.(1840-1842)cCa>cTa	p.P614L	ENOX1_ENST00000412891.1_Missense_Mutation_p.P614L	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	614					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GAACATGCGTGGCAGCCTCAT	0.428000													13	111					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55356487	55356487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55356487C>T	ENST00000524622.1	-	7	1442	c.781G>A	c.(781-783)Gat>Aat	p.D261N	TESPA1_ENST00000531122.1_Missense_Mutation_p.D261N|TESPA1_ENST00000449076.1_Missense_Mutation_p.D399N|TESPA1_ENST00000532804.1_Missense_Mutation_p.D261N|TESPA1_ENST00000316577.8_Missense_Mutation_p.D399N	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	399																	CACTGTGGATCTTCTATGGGC	0.517000													27	103					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122626202	122626202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:122626202C>T	ENST00000263461.6	+	8	1362	c.1116C>T	c.(1114-1116)gcC>gcT	p.A372A		NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	372						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						ATGCAGCCGCCCTCGTAGTGA	0.463000													44	104					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123419462	123419462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123419462G>A	ENST00000360772.3	-	19	3231	c.2853C>T	c.(2851-2853)gtC>gtT	p.V951V	MYLK_ENST00000346322.5_Silent_p.V882V|MYLK_ENST00000359169.1_Silent_p.V951V|MYLK_ENST00000475616.1_Silent_p.V951V|MYLK_ENST00000360304.3_Silent_p.V951V			Q15746	MYLK_HUMAN	myosin light chain kinase	951	5 X 28 AA approximate tandem repeats.|Actin-binding (calcium/calmodulin- sensitive) (By similarity).|Calmodulin-binding (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AGCGAAAATCGACCTGCTGGG	0.597000													24	50					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10753581	10753581	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10753581C>T	ENST00000586078.1	+	22	2132	c.2023C>T	c.(2023-2025)Ctg>Ttg	p.L675L	SLC44A2_ENST00000407327.4_Intron|SLC44A2_ENST00000335757.5_Intron	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	675					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	AGGTGAGGACCTGGAAAGGAA	0.637000													3	14					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53516948	53516948	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53516948C>T	ENST00000301466.3	+	13	1380	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	440					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						TCTTCTGCTTCGTCCTGGGGT	0.592000													20	66					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43896592	43896592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43896592C>T	ENST00000261488.6	-	11	1766	c.1189G>A	c.(1189-1191)Gaa>Aaa	p.E397K	ENOX1_ENST00000540032.1_Missense_Mutation_p.E210K|ENOX1_ENST00000412891.1_Missense_Mutation_p.E397K	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	397					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		ATTTCTTCTTCGCGGCGGATG	0.478000													30	58					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54963142	54963142	+	Silent	SNP	C	C	T	rs151025806	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54963142C>T	ENST00000243052.3	+	4	838	c.402C>T	c.(400-402)ttC>ttT	p.F134F	PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Silent_p.F93F|PDE1B_ENST00000550620.1_Silent_p.F114F	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	134					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						CTGGGATCTTCGTGGAACGGT	0.622000													11	32					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56078540	56078540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56078540C>T	ENST00000429804.2	-	9	2202	c.1642G>A	c.(1642-1644)Ggt>Agt	p.G548S	CTCFL_ENST00000426658.2_3'UTR|CTCFL_ENST00000422109.2_3'UTR|CTCFL_ENST00000423479.2_Missense_Mutation_p.G598S|CTCFL_ENST00000371196.2_Missense_Mutation_p.G598S|CTCFL_ENST00000243914.3_Missense_Mutation_p.G598S|CTCFL_ENST00000433949.2_Missense_Mutation_p.G598S|CTCFL_ENST00000502686.2_Missense_Mutation_p.G336S	NM_001269046.1	NP_001255975.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	598					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			TCCTTCTGACCCTTTGTGGCT	0.498000													52	103					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117566802	117566802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117566802C>T	ENST00000254029.3	+	13	2191	c.1796C>T	c.(1795-1797)cCa>cTa	p.P599L	WDR44_ENST00000371825.3_Missense_Mutation_p.P599L|WDR44_ENST00000371822.5_Missense_Mutation_p.P574L	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	599						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						CGGCAACGGCCATTTTGCAAA	0.348000													61	58					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21860965	21860965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21860965G>A	ENST00000399982.2	-	33	6536	c.6472C>T	c.(6472-6474)Cgt>Tgt	p.R2158C	CHD8_ENST00000557364.1_Missense_Mutation_p.R2158C|CHD8_ENST00000430710.3_Missense_Mutation_p.R1879C	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2158					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ATCAGGACACGATCCTGAATG	0.463000													12	151					0	0	1	0	0
GP9	2815	broad.mit.edu	37	3	128780587	128780587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:128780587C>T	ENST00000307395.4	+	3	227	c.5C>T	c.(4-6)cCt>cTt	p.P2L		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	2					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	TGTCCCATGCCTGCCTGGGGA	0.682000													6	16					0	0	1	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086676	46086676	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46086676G>A	ENST00000360770.3	-	1	168	c.128C>T	c.(127-129)tCc>tTc	p.S43F	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	43	23 X 5 AA approximate repeats.					keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						CACACACACGGAGGACTGGCA	0.657000													15	45					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19194885	19194885	+	Missense_Mutation	SNP	G	G	A	rs149672382		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19194885G>A	ENST00000562034.1	+	3	3982	c.184G>A	c.(184-186)Gat>Aat	p.D62N	SYT17_ENST00000355377.2_Missense_Mutation_p.D123N|SYT17_ENST00000568115.1_Missense_Mutation_p.D62N|SYT17_ENST00000562711.2_Missense_Mutation_p.D119N			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	123						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						TCCACTCATCGATATTAAACC	0.527000													15	130					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159283541	159283541	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159283541C>T	ENST00000332217.5	-	1	908	c.909G>A	c.(907-909)caG>caA	p.Q303Q		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					CCCCACGGCTCTGTGCAGAGC	0.433000													39	82					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15374430	15374430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:15374430C>T	ENST00000341776.2	+	2	372	c.128C>T	c.(127-129)tCc>tTc	p.S43F	JARID2_ENST00000397311.3_5'UTR	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	43					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				TTCAAGAATTCCCAGAAGAGG	0.443000													65	131					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3656551	3656551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3656551G>A	ENST00000335312.3	-	6	561	c.473C>T	c.(472-474)tCc>tTc	p.S158F	PIP5K1C_ENST00000589578.1_Missense_Mutation_p.S158F|PIP5K1C_ENST00000587482.1_5'UTR|PIP5K1C_ENST00000539785.1_Missense_Mutation_p.S158F|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.S158F	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	158	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		ATTGCACAGGGAGTACTGGAA	0.622000													23	63					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501062	90501062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90501062G>A	ENST00000325643.5	+	4	1726	c.1660G>A	c.(1660-1662)Gag>Aag	p.E554K		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1									p.E554K(1)									TACATCCCAGGAGAGGACACA	0.562000													52	127					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663440	34663440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34663440G>A	ENST00000488417.1	+	2	1055	c.935G>A	c.(934-936)aGg>aAg	p.R312K	C1orf94_ENST00000373374.3_Missense_Mutation_p.R122K	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	122							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				GCTCAGAAGAGGCAGCTCCCA	0.612000													15	39					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569725	241569725	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241569725G>A	ENST00000319838.5	+	6	1298	c.356G>A	c.(355-357)cGg>cAg	p.R119Q	GPR35_ENST00000438013.2_Missense_Mutation_p.R150Q|GPR35_ENST00000407714.1_Missense_Mutation_p.R119Q|GPR35_ENST00000430267.1_Missense_Mutation_p.R119Q|GPR35_ENST00000403859.1_Missense_Mutation_p.R119Q	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	119						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GTGGCCGTGCGGCACCCGCTG	0.706000													9	25					0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95947690	95947690	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:95947690G>A	ENST00000317620.9	+	13	1702	c.1569G>A	c.(1567-1569)ggG>ggA	p.G523G	PROM2_ENST00000317668.4_Silent_p.G523G|PROM2_ENST00000542147.1_Silent_p.G523G|PROM2_ENST00000403131.2_Silent_p.G523G	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	523						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						ACACCCCAGGGAACCTGCCCC	0.627000													8	113					0	0	1	0	0
TPD52L3	89882	broad.mit.edu	37	9	6328916	6328916	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:6328916G>A	ENST00000344545.5	+	1	568	c.321G>A	c.(319-321)agG>agA	p.R107R	TPD52L3_ENST00000314556.3_Silent_p.R107R|TPD52L3_ENST00000381428.1_Silent_p.R107R	NM_033516.5	NP_277051.3	Q96J77	TPD55_HUMAN	tumor protein D52-like 3	107							protein binding			large_intestine(1)|lung(9)|skin(1)	11		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		TCATCTGCAGGAAGCTTGGAG	0.507000													30	52					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92953005	92953005	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92953005C>T	ENST00000544910.1	+	22	2068	c.1848C>T	c.(1846-1848)taC>taT	p.Y616Y	CCDC132_ENST00000541136.1_Silent_p.Y457Y|CCDC132_ENST00000305866.5_Silent_p.Y646Y|CCDC132_ENST00000535481.1_Silent_p.Y366Y	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	646										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGATTATTACTTGTATGCAA	0.269000													9	38					0	0	1	0	0
IGLV2-18	28814	broad.mit.edu	37	22	23077472	23077472	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23077472C>T	ENST00000390310.2	+	0	262																											CTGATCGCTTCTCTGGGTCCA	0.557000													114	237					0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048773	6048773	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6048773G>A	ENST00000316650.5	-	1	198	c.162C>T	c.(160-162)atC>atT	p.I54I		NM_001001917.2	NP_001001917.2	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A, member 1	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I54I(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGGATGGTGATCAGGAGGG	0.612000													34	60					0	0	1	0	0
NMNAT2	23057	broad.mit.edu	37	1	183230174	183230174	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183230174T>C	ENST00000287713.6	-	10	1118	c.784A>G	c.(784-786)Aac>Gac	p.N262D	NMNAT2_ENST00000294868.4_Missense_Mutation_p.N257D	NM_015039.3	NP_055854.1	Q9BZQ4	NMNA2_HUMAN	nicotinamide nucleotide adenylyltransferase 2	262					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	18						atgggatggttgatgtcatcc	0.458000													41	94					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25399814	25399814	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25399814G>A	ENST00000255324.5	+	16	2201	c.2149G>A	c.(2149-2151)Gaa>Aaa	p.E717K	RNF17_ENST00000381921.1_Missense_Mutation_p.E717K	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	717					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTATAAAAGTGAAGATGGAGA	0.358000													36	100					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52942420	52942420	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52942420G>A	ENST00000332323.6	+	4	1807	c.1746G>A	c.(1744-1746)agG>agA	p.R582R	ZNF534_ENST00000433050.1_Silent_p.R569R|ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000432303.2_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	582					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						CGCGACATAGGAATATTCATA	0.443000													9	17					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529496	5529496	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5529496C>T	ENST00000311659.4	-	2	1440	c.1293G>A	c.(1291-1293)ggG>ggA	p.G431G	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	431										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGAGCTTTTCCCTGCACCAT	0.517000													41	81					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731945	140731945	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140731945G>A	ENST00000523390.1	+	1	2118	c.2118G>A	c.(2116-2118)gcG>gcA	p.A706A	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATTCTAGCGATCGCCCTGC	0.612000													63	179					0	0	1	0	0
FAM135A	57579	broad.mit.edu	37	6	71191790	71191790	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:71191790C>T	ENST00000418814.2	+	10	1370	c.756C>T	c.(754-756)ttC>ttT	p.F252F	FAM135A_ENST00000370479.3_Silent_p.F209F|FAM135A_ENST00000361499.3_Silent_p.F252F|FAM135A_ENST00000505868.1_Silent_p.F252F|FAM135A_ENST00000505769.1_Silent_p.F252F|FAM135A_ENST00000457062.2_Silent_p.F209F	NM_001105531.2|NM_001162529.1	NP_001099001.1|NP_001156001.1	Q9P2D6	F135A_HUMAN	family with sequence similarity 135, member A	252										breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38						TGCTAGCCTTCAAGGGATTGC	0.393000													30	62					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5355600	5355600	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:5355600G>A	ENST00000399537.4	-	25	7197	c.6849C>T	c.(6847-6849)gaC>gaT	p.D2283D	TNRC18_ENST00000430969.1_Silent_p.D2283D			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2283							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GTATCTTATAGTCAGGGGGCA	0.612000													6	22					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642007	57642007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57642007G>A	ENST00000254181.4	+	4	2418	c.1964G>A	c.(1963-1965)gGa>gAa	p.G655E	USP29_ENST00000598197.1_Missense_Mutation_p.G655E	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	655					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGGACCAGGGAGACATTTCT	0.493000													14	39					0	0	1	0	0
FETUB	26998	broad.mit.edu	37	3	186364116	186364116	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186364116C>T	ENST00000265029.3	+	5	775	c.674C>T	c.(673-675)tCa>tTa	p.S225L	FETUB_ENST00000539949.1_Missense_Mutation_p.S77L|FETUB_ENST00000382134.3_Missense_Mutation_p.S160L|RP11-134F2.2_ENST00000428501.1_RNA|FETUB_ENST00000382136.3_Missense_Mutation_p.S188L|FETUB_ENST00000450521.1_Missense_Mutation_p.S225L|RP11-134F2.2_ENST00000455926.1_RNA	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	225	Cystatin fetuin-B-type 2.					extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		AGCAGCTGTTCACTTCAGTCC	0.408000													47	125					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56090698	56090698	+	Silent	SNP	G	G	A	rs142311782	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56090698G>A	ENST00000257880.7	-	13	2073	c.1854C>T	c.(1852-1854)gcC>gcT	p.A618A	ITGA7_ENST00000553804.1_Silent_p.A578A|ITGA7_ENST00000394229.2_Silent_p.A574A|ITGA7_ENST00000394230.2_Silent_p.A578A|ITGA7_ENST00000347027.6_Silent_p.A568A|ITGA7_ENST00000257879.6_Silent_p.A574A|ITGA7_ENST00000555728.1_Silent_p.A618A|ITGA7_ENST00000452168.2_Silent_p.A481A			Q13683	ITA7_HUMAN	integrin, alpha 7	618					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GCTGGAACATGGCGTCTCCAC	0.572000													10	35					0	0	1	0	0
IL10RA	3587	broad.mit.edu	37	11	117870052	117870052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117870052G>A	ENST00000227752.3	+	7	1553	c.1433G>A	c.(1432-1434)gGg>gAg	p.G478E	IL10RA_ENST00000541785.1_Missense_Mutation_p.G458E|IL10RA_ENST00000545409.1_Missense_Mutation_p.G329E|IL10RA_ENST00000533700.1_3'UTR	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	478						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CCCAAATTCGGGAGATGCCTG	0.562000													19	69					0	0	1	0	0
LOC283194	283194	broad.mit.edu	37	11	58746740	58746740	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58746740C>T	ENST00000533954.1	-	0	614				RP11-142C4.6_ENST00000532098.1_RNA|RP11-142C4.6_ENST00000525714.1_RNA	NR_033853.1																						ATCCAGATCTCCATCTCTGAG	0.473000													7	16					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108618544	108618544	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108618544C>T	ENST00000332082.4	+	6	1529	c.711C>T	c.(709-711)ttC>ttT	p.F237F	WSCD2_ENST00000547525.1_Silent_p.F237F|WSCD2_ENST00000261400.3_Silent_p.F237F|WSCD2_ENST00000549903.1_Silent_p.F237F			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	237	WSC 2.					integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						GGGGCTGCTTCCGCAGGCCCG	0.532000													27	93					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102337651	102337651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:102337651C>T	ENST00000369138.1	+	11	2151	c.1661C>T	c.(1660-1662)tCc>tTc	p.S554F	GRIK2_ENST00000369137.3_Intron|GRIK2_ENST00000413795.1_Missense_Mutation_p.S554F|GRIK2_ENST00000318991.6_Missense_Mutation_p.S554F|GRIK2_ENST00000369134.4_Missense_Mutation_p.S505F|GRIK2_ENST00000421544.1_Missense_Mutation_p.S554F	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	554					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GGCGTCTTCTCCTTCCTGAAT	0.458000													58	121					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67183865	67183865	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67183865G>A	ENST00000269081.4	-	20	3196	c.2287C>T	c.(2287-2289)Cgc>Tgc	p.R763C	ABCA10_ENST00000416101.2_3'UTR	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	763					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					TTTAAGAAGCGAAGTGTTGCC	0.383000													33	85					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21213507	21213507	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21213507G>T	ENST00000574002.1	-	12	1687	c.1205C>A	c.(1204-1206)tCc>tAc	p.S402Y	ZP2_ENST00000219593.4_Missense_Mutation_p.S402Y|AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Missense_Mutation_p.S402Y			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	402	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		AGGCTGGCAGGATGAGTTTCC	0.542000													12	39					7.03913e-09	7.06481e-09	1	1	0
SLC16A3	9123	broad.mit.edu	37	17	80195264	80195264	+	Silent	SNP	G	G	A	rs5822442		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80195264G>A	ENST00000581287.1	+	3	2940	c.618G>A	c.(616-618)ccG>ccA	p.P206P	SLC16A3_ENST00000392339.1_Silent_p.P206P|SLC16A3_ENST00000392341.1_Silent_p.P206P|SLC16A3_ENST00000582743.1_Silent_p.P206P	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	206					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	CGGCCCAGCCGGGCTCGGGGC	0.721000													3	6					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19339423	19339423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19339423C>T	ENST00000252575.5	+	8	3037	c.2994C>T	c.(2992-2994)acC>acT	p.T998T	NCAN_ENST00000538881.1_Silent_p.T449T	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	998					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			TGCCAGGGACCCCTATGAATG	0.642000													15	54					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87969864	87969864	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:87969864C>T	ENST00000369577.3	+	8	6560	c.6517C>T	c.(6517-6519)Cga>Tga	p.R2173*	ZNF292_ENST00000339907.4_Nonsense_Mutation_p.R2168*	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	2173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GAAAGAATTTCGATGTCAGGT	0.368000													60	112					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83180398	83180398	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:83180398C>T	ENST00000398309.2	-	20	2620	c.2150G>A	c.(2149-2151)cGa>cAa	p.R717Q	DLG2_ENST00000376106.3_Missense_Mutation_p.R181Q|DLG2_ENST00000524982.1_Missense_Mutation_p.R713Q|DLG2_ENST00000532653.1_Missense_Mutation_p.R699Q|DLG2_ENST00000330014.6_Missense_Mutation_p.R638Q|DLG2_ENST00000543673.1_Missense_Mutation_p.R822Q|DLG2_ENST00000376104.2_Missense_Mutation_p.R822Q|DLG2_ENST00000280241.8_Missense_Mutation_p.R756Q|DLG2_ENST00000531015.1_Missense_Mutation_p.R684Q|DLG2_ENST00000537455.1_Missense_Mutation_p.R467Q|DLG2_ENST00000418306.2_Missense_Mutation_p.R596Q|DLG2_ENST00000426717.2_Missense_Mutation_p.R181Q|DLG2_ENST00000404783.3_Missense_Mutation_p.R195Q	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	717	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CTCGTAGTCTCGCTTTGGCCT	0.388000													27	121					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102968013	102968013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102968013G>A	ENST00000233954.1	+	11	1574	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K		NM_016232.4	NP_057316.3	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	435	TIR.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						CACTGCAGTGGAAACCAACAT	0.413000													21	66					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454619	84454619	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:84454619G>A	ENST00000377084.2	-	1	1909	c.1024C>T	c.(1024-1026)Cct>Tct	p.P342S		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	342	LRRNT 2.					integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CAGCCCCCAGGGCAGGGTAAA	0.537000													8	103					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18393374	18393374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:18393374G>A	ENST00000440756.2	-	16	3131	c.3029C>T	c.(3028-3030)tCg>tTg	p.S1010L	PSD3_ENST00000327040.8_Missense_Mutation_p.S1008L|PSD3_ENST00000286485.8_Missense_Mutation_p.S474L|PSD3_ENST00000428502.2_Missense_Mutation_p.S337L|PSD3_ENST00000523619.1_Missense_Mutation_p.S943L			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	1009					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACTCGAGTGCGACTTCTTCAG	0.498000													29	66					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6333529	6333529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6333529C>T	ENST00000301452.4	-	1	111	c.34G>A	c.(34-36)Gtg>Atg	p.V12M		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	12						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						CACCAGTCCACCTCGGAGCTC	0.617000													6	12					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47950683	47950683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47950683G>A	ENST00000426837.2	-	10	5366	c.5279C>T	c.(5278-5280)tCa>tTa	p.S1760L	MAP4_ENST00000383737.4_Missense_Mutation_p.S343L|MAP4_ENST00000395734.3_Intron|MAP4_ENST00000360240.6_Intron|MAP4_ENST00000264724.11_Missense_Mutation_p.S350L			P27816	MAP4_HUMAN	microtubule-associated protein 4	626					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGGTGTCTTTGATTCAGATTT	0.428000													29	94					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596346	24596346	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24596346C>T	ENST00000535378.1	-	4	1171	c.529G>A	c.(529-531)Ggc>Agc	p.G177S	KIAA0319_ENST00000378214.3_Missense_Mutation_p.G186S|KIAA0319_ENST00000430948.2_Missense_Mutation_p.G141S|KIAA0319_ENST00000543707.1_Missense_Mutation_p.G186S|KIAA0319_ENST00000537886.1_Missense_Mutation_p.G186S	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	186					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GGCAGTAGGCCCCAGTCCGTG	0.617000													17	35					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49812813	49812813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49812813C>T	ENST00000249601.4	-	1	325	c.29G>A	c.(28-30)aGg>aAg	p.R10K	ARHGAP22_ENST00000435790.2_Intron|ARHGAP22_ENST00000417912.2_Missense_Mutation_p.R10K|ARHGAP22_ENST00000491108.1_5'UTR	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	10					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTTACCCCTCCTGGCCTGCCT	0.607000													25	70					0	0	1	0	0
AADAC	13	broad.mit.edu	37	3	151542595	151542595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151542595G>A	ENST00000232892.6	+	4	702	c.576G>A	c.(574-576)ggG>ggA	p.G192G	RP11-454C18.2_ENST00000475855.1_RNA|AADAC_ENST00000488869.1_Silent_p.G192G|RP11-454C18.2_ENST00000483843.2_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	192					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GTGCAGGAGGGAATTTAGCTG	0.338000													13	51					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124080952	124080952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:124080952C>T	ENST00000373823.3	+	17	1890	c.985C>T	c.(985-987)Ctt>Ttt	p.L329F	GSN_ENST00000373807.1_Missense_Mutation_p.L111F|GSN_ENST00000436847.1_Missense_Mutation_p.L340F|GSN_ENST00000341272.2_Missense_Mutation_p.L329F|GSN_ENST00000373818.4_Missense_Mutation_p.L380F|GSN_ENST00000394353.2_Missense_Mutation_p.L340F|GSN_ENST00000545652.1_Missense_Mutation_p.L337F|GSN_ENST00000449733.1_Missense_Mutation_p.L329F|GSN_ENST00000373808.2_Missense_Mutation_p.L329F|GSN_ENST00000412819.1_Missense_Mutation_p.L329F			P06396	GELS_HUMAN	gelsolin	380					actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						GGTCTCGGTCCTTCCTGAGGG	0.632000													18	51					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25479434	25479434	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25479434G>A	ENST00000453082.2	+	0	1891				SNORD115-35_ENST00000365122.1_RNA	NR_003343.1																						GAAGAGAGGTGATGACTTAAA	0.502000													113	355					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241831098	241831098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241831098G>A	ENST00000307486.8	-	2	248	c.150C>T	c.(148-150)ttC>ttT	p.F50F	C2orf54_ENST00000402775.2_Silent_p.F31F|C2orf54_ENST00000388934.4_Silent_p.F199F			Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	199										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		GCACCACGTGGAAGCTGATTG	0.627000													39	73					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124389907	124389907	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124389907A>G	ENST00000368909.3	+	45	5645	c.5539A>G	c.(5539-5541)Ata>Gta	p.I1847V	DMBT1_ENST00000330163.4_Missense_Mutation_p.I1219V|DMBT1_ENST00000368955.3_Missense_Mutation_p.I1837V|DMBT1_ENST00000359586.6_Missense_Mutation_p.I567V|DMBT1_ENST00000368956.2_Missense_Mutation_p.I1219V|DMBT1_ENST00000344338.3_Missense_Mutation_p.I1837V|DMBT1_ENST00000338354.3_Missense_Mutation_p.I1847V	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1847	CUB 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TACCAGGCAAATATTTACATC	0.408000													26	51					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94716543	94716543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94716543C>T	ENST00000304338.3	+	15	1800	c.1646C>T	c.(1645-1647)aCt>aTt	p.T549I		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	549						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						GCTTCACGAACTCTATGCATT	0.348000													27	54					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61843365	61843365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61843365C>T	ENST00000280772.1	-	33	4276	c.4085G>A	c.(4084-4086)gGa>gAa	p.G1362E	ANK3_ENST00000503366.1_Missense_Mutation_p.G1363E|ANK3_ENST00000373827.2_Missense_Mutation_p.G1356E|ANK3_ENST00000355288.2_Missense_Mutation_p.G496E	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1362					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.G496E(2)|p.G1362E(2)		NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AATAGGTTTTCCTTCCAGAAC	0.299000													23	65					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501775	90501775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90501775G>A	ENST00000325643.5	+	4	2439	c.2373G>A	c.(2371-2373)atG>atA	p.M791I		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CCTGGCTCATGGCCAAATGTG	0.572000													12	57					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63966615	63966615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:63966615C>T	ENST00000443617.2	-	38	7859	c.7772G>A	c.(7771-7773)cGa>cAa	p.R2591Q		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2591					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GGCTTGCGCTCGTTCCAGATC	0.448000													11	67					0	0	1	0	0
OR10K2	391107	broad.mit.edu	37	1	158389857	158389857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158389857G>A	ENST00000314902.2	-	1	799	c.800C>T	c.(799-801)tCc>tTc	p.S267F		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					CTGGCTTGAGGAGTAGTTGGA	0.398000													25	74					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995456	140995456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140995456C>T	ENST00000285879.4	+	4	2552	c.2266C>T	c.(2266-2268)Ccc>Tcc	p.P756S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	756							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGAGTCTTCCCCAGAGTTT	0.547000										HNSCC(15;0.026)			96	101					0	0	1	0	0
LEMD1	93273	broad.mit.edu	37	1	205350899	205350899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205350899C>T	ENST00000367153.4	-	6	535	c.433G>A	c.(433-435)Gag>Aag	p.E145K	LEMD1_ENST00000367154.1_Silent_p.S97S|LEMD1_ENST00000367151.2_Missense_Mutation_p.E104K|LEMD1_ENST00000476884.1_5'UTR|LEMD1-AS1_ENST00000447832.1_RNA|LEMD1_ENST00000367149.3_Silent_p.S56S|LEMD1_ENST00000391936.2_Silent_p.S97S|LEMD1_ENST00000367152.1_Missense_Mutation_p.E104K	NM_001199050.1	NP_001185979.1	Q68G75	LEMD1_HUMAN	LEM domain containing 1	145						integral to membrane|nuclear envelope				breast(1)|lung(2)	3	Breast(84;0.247)		BRCA - Breast invasive adenocarcinoma(75;0.0938)			CTCCAGCTCTCGATAGTCTGG	0.478000													69	162					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57136731	57136731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:57136731C>T	ENST00000439986.4	-	4	411	c.374G>A	c.(373-375)cGg>cAg	p.R125Q	CCBE1_ENST00000398179.2_5'UTR	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	125					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				CTCCCGCTTCCGGTGTCTCTC	0.537000													26	136					0	0	1	0	0
INTS12	57117	broad.mit.edu	37	4	106621017	106621017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:106621017G>A	ENST00000451321.2	-	2	625	c.146C>T	c.(145-147)cCa>cTa	p.P49L	INTS12_ENST00000340139.5_Missense_Mutation_p.P49L|INTS12_ENST00000394735.1_Missense_Mutation_p.P49L	NM_001142471.1	NP_001135943.1	Q96CB8	INT12_HUMAN	integrator complex subunit 12	49					snRNA processing	integrator complex	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		CTTTTGAGATGGACGGTAACT	0.388000													27	226					0	0	1	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46937265	46937265	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46937265C>T	ENST00000429979.1	-	6	1514	c.910G>A	c.(910-912)Gaa>Aaa	p.E304K	KIAA0226L_ENST00000409879.2_Missense_Mutation_p.E147K|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.E169K|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.E304K|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.E237K|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.E304K|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.E147K|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.E304K|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.E304K	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	304										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						ATAACAAATTCATCAACATCG	0.423000													9	38					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413716	48413716	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48413716G>A	ENST00000249598.1	-	2	1311	c.1152C>T	c.(1150-1152)ttC>ttT	p.F384F		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	384					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CCTTTGTGGGGAACTTGAGAT	0.577000													6	39					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145562487	145562487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145562487C>T	ENST00000355594.4	+	10	2262	c.2175C>T	c.(2173-2175)tcC>tcT	p.S725S		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	725										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAGCGGAGTCCCTGGAGGAGC	0.667000													3	18					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169663684	169663684	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169663684G>A	ENST00000483289.2	-	0	3610				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						CAGGGCAGGAGCCCCTGTCAG	0.443000													13	92					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139907985	139907985	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139907985G>A	ENST00000265662.5	-	29	4625	c.4478C>T	c.(4477-4479)tCc>tTc	p.S1493F	ABCA2_ENST00000371605.3_Missense_Mutation_p.S1492F|ABCA2_ENST00000341511.6_Missense_Mutation_p.S1493F			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1492					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GTGGTACTGGGAAGGTGACAG	0.687000													4	12					0	0	1	0	0
NT5M	56953	broad.mit.edu	37	17	17250254	17250254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:17250254C>T	ENST00000389022.4	+	5	896	c.680C>T	c.(679-681)cCc>cTc	p.P227L	NT5M_ENST00000582909.1_3'UTR	NM_020201.3	NP_064586.1	Q9NPB1	NT5M_HUMAN	5',3'-nucleotidase, mitochondrial	227					DNA replication|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	5'-nucleotidase activity|metal ion binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4						AGCAAGCGGCCCTGCTGAGCT	0.682000													15	32					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81201555	81201555	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81201555G>A	ENST00000394685.3	+	14	2124	c.1705G>A	c.(1705-1707)Gga>Aga	p.G569R	RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000356249.5_Missense_Mutation_p.G569R|KIAA1199_ENST00000220244.3_Missense_Mutation_p.G569R|RP11-351M8.1_ENST00000560560.1_Intron			Q8WUJ3	K1199_HUMAN	KIAA1199	569										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						AGACGAAAGGGGAGGTTATGA	0.552000													23	77					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31441270	31441270	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:31441270G>A	ENST00000373747.3	-	11	1678	c.1579C>T	c.(1579-1581)Ccc>Tcc	p.P527S	PUM1_ENST00000257075.5_Missense_Mutation_p.P526S|PUM1_ENST00000426105.2_Missense_Mutation_p.P526S|PUM1_ENST00000424085.2_Missense_Mutation_p.P284S|PUM1_ENST00000373741.4_Missense_Mutation_p.P562S|PUM1_ENST00000423018.2_Missense_Mutation_p.P430S|PUM1_ENST00000373742.2_Missense_Mutation_p.P467S|PUM1_ENST00000490546.1_5'UTR|PUM1_ENST00000440538.2_Missense_Mutation_p.P527S	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	526	Ala-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		GCCACAAGGGGATCCGTTTGC	0.532000													22	60					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73567066	73567066	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73567066C>T	ENST00000392550.3	+	17	2178	c.2061C>T	c.(2059-2061)ggC>ggT	p.G687G	LLGL2_ENST00000577200.1_Silent_p.G687G|LLGL2_ENST00000167462.5_Silent_p.G687G	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	687					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			AGCGGCCAGGCCTCCAGAACA	0.642000													33	92					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84070370	84070370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84070370G>A	ENST00000299709.3	-	2	324	c.325C>T	c.(325-327)Ctc>Ttc	p.L109F		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	109					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						AGGTTGAGGAGGAAGCAGGCC	0.632000													10	37					0	0	1	0	0
VCP	7415	broad.mit.edu	37	9	35060446	35060446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35060446G>A	ENST00000358901.6	-	13	2454	c.1559C>T	c.(1558-1560)cCt>cTt	p.P520L		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	520					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCCACAGCCAGGAGGTCCATA	0.498000													27	58					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124810341	124810341	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124810341C>T	ENST00000423114.2	-	12	1949	c.1950G>A	c.(1948-1950)atG>atA	p.M650I	SLC12A8_ENST00000469902.1_Missense_Mutation_p.M621I|SLC12A8_ENST00000314584.7_Intron|SLC12A8_ENST00000430155.2_Missense_Mutation_p.M422I|SLC12A8_ENST00000465475.1_Intron|SLC12A8_ENST00000393469.4_Missense_Mutation_p.M621I			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	621					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						CAGCAACACCCATGTTAACCA	0.493000													12	59					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79343107	79343107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79343107C>T	ENST00000264895.6	+	34	5071	c.4631C>T	c.(4630-4632)cCc>cTc	p.P1544L	FRAS1_ENST00000325942.6_Missense_Mutation_p.P1544L	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1543					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TACCGCCCTCCCCCGGCAGCA	0.572000													61	144					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5687648	5687648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5687648G>A	ENST00000356134.5	-	23	2344	c.2273C>T	c.(2272-2274)tCc>tTc	p.S758F	ANO2_ENST00000327087.8_Missense_Mutation_p.S757F|ANO2_ENST00000546188.1_Missense_Mutation_p.S758F	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	762						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CAGGGGAAAGGAGGCCACGAA	0.542000													4	24					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89521767	89521767	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89521767G>A	ENST00000370473.4	-	8	1519	c.1300C>T	c.(1300-1302)Cgt>Tgt	p.R434C		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	434					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity	p.R434C(1)		endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		ACAAAGAGACGATAGCCCCCT	0.428000													121	342					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19752827	19752827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19752827G>A	ENST00000203556.4	-	3	275	c.138C>T	c.(136-138)ctC>ctT	p.L46L	GMIP_ENST00000445806.2_Silent_p.L46L|GMIP_ENST00000587238.1_Silent_p.L46L	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	46					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GGTCTTCTGAGAGTAGAGGGT	0.582000													10	25					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50220961	50220961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50220961C>T	ENST00000002829.3	+	12	1681	c.1197C>T	c.(1195-1197)ccC>ccT	p.P399P	SEMA3F_ENST00000434342.1_Silent_p.P368P|SEMA3F_ENST00000413852.1_Silent_p.P300P	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	399	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		AGTGGATGCCCTTCTCAGGGA	0.592000													31	69					0	0	1	0	0
LOC101927958	101927958	broad.mit.edu	37	2	239141527	239141527	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239141527C>T	ENST00000456601.1	+	0	906																											GGATCAGCATCCAATGCAGGG	0.502000													33	59					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6943094	6943094	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6943094C>T	ENST00000251761.8	+	0	1372				LEPREL2_ENST00000538102.1_RNA|LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						GGCAGATGTCCTTCTCCTGGA	0.642000													21	79					0	0	1	0	0
SUSD2	56241	broad.mit.edu	37	22	24583561	24583561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:24583561C>T	ENST00000358321.3	+	12	2175	c.1914C>T	c.(1912-1914)tcC>tcT	p.S638S		NM_019601.3	NP_062547.1	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2	638	VWFD.				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26						ATGCGTCCTCCCTGCTCACCT	0.612000													20	67					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583817	82583817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82583817C>T	ENST00000423517.2	-	5	6789	c.6452G>A	c.(6451-6453)aGa>aAa	p.R2151K	PCLO_ENST00000333891.8_Missense_Mutation_p.R2151K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2082					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGAATTTCTCTTGTATAATC	0.413000													21	74					0	0	1	0	0
KLK1	3816	broad.mit.edu	37	19	51322476	51322476	+	Missense_Mutation	SNP	C	C	T	rs138173062		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51322476C>T	ENST00000448701.2	-	6	1781	c.457G>A	c.(457-459)Gag>Aag	p.E153K	KLK1_ENST00000301420.2_Missense_Mutation_p.E255K			P06870	KLK1_HUMAN	kallikrein 1	255	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity			breast(1)|large_intestine(4)|lung(7)|urinary_tract(1)	13		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATGGTGTCCTCGATCCACTTC	0.542000													15	96					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38397257	38397257	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:38397257G>A	ENST00000377698.3	+	2	1665	c.1512G>A	c.(1510-1512)gaG>gaA	p.E504E		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	504					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CCTACACAGAGGTAAAGACGG	0.532000													7	29					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92616111	92616111	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92616111C>T	ENST00000298047.6	+	23	12506	c.12489C>T	c.(12487-12489)ttC>ttT	p.F4163F	FAT3_ENST00000533797.1_Silent_p.F498F|FAT3_ENST00000409404.2_Silent_p.F4163F|FAT3_ENST00000525166.1_Silent_p.F4013F			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4163					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGTCCTCTTCGTCATCTTCA	0.592000										TCGA Ovarian(4;0.039)			12	17					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208515	140208515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140208515C>T	ENST00000529310.1	+	1	953	c.839C>T	c.(838-840)tCt>tTt	p.S280F	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.S280F	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTCATATTCTTTTAATAGC	0.388000													69	144					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6180466	6180466	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6180466G>A	ENST00000261405.5	-	10	1407	c.1153C>T	c.(1153-1155)Cca>Tca	p.P385S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	385					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CGCCTACCTGGACATTCTTCA	0.542000													16	35					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356406	40356406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40356406G>A	ENST00000310169.2	+	5	1448	c.1309G>A	c.(1309-1311)Gac>Aac	p.D437N		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	437					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	GTGCCTCAAAGACCACAAGGC	0.483000													12	111					0	0	1	0	0
PAX1	5075	broad.mit.edu	37	20	21689975	21689975	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:21689975C>T	ENST00000398485.2	+	4	1229	c.1175C>T	c.(1174-1176)cCg>cTg	p.P392L	PAX1_ENST00000460221.1_3'UTR|PAX1_ENST00000444366.2_Missense_Mutation_p.P368L	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	392					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						CCGGGCCCGCCGTGGCCGCCT	0.746000													31	10					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065523	35065523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35065523G>A	ENST00000382002.5	-	10	1963	c.1537C>T	c.(1537-1539)Cac>Tac	p.H513Y	PRLR_ENST00000513753.1_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.H412Y|PRLR_ENST00000511486.1_Missense_Mutation_p.H412Y|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	513					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity	p.H513Y(1)		central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTGACCTTGTGAATCTCCACA	0.502000													46	90					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248039405	248039405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248039405G>A	ENST00000366481.3	+	6	1123	c.1075G>A	c.(1075-1077)Ggt>Agt	p.G359S	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	359	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGCAGAGTGGGGTTTAGGGGT	0.562000													30	66					0	0	1	0	0
GPR142	350383	broad.mit.edu	37	17	72368159	72368159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72368159C>T	ENST00000335666.4	+	4	857	c.809C>T	c.(808-810)tCg>tTg	p.S270L		NM_181790.1	NP_861455.1	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	270						cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(21)|ovary(2)|prostate(1)|skin(4)	35						CGGGCCGCCTCGTCCCCAGGC	0.657000													7	30					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42853767	42853767	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42853767C>A	ENST00000334370.4	+	13	2849	c.2214C>A	c.(2212-2214)atC>atA	p.I738I	MEGF8_ENST00000251268.6_Silent_p.I805I	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	805						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CAGTAGAGATCCAGGGCCAGC	0.657000													5	53					2.0095e-06	2.01378e-06	1	1	0
COL6A2	1292	broad.mit.edu	37	21	47545985	47545985	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47545985C>A	ENST00000300527.4	+	26	2360	c.2256C>A	c.(2254-2256)gtC>gtA	p.V752V	COL6A2_ENST00000397763.1_Silent_p.V752V|COL6A2_ENST00000409416.1_Silent_p.V752V|COL6A2_ENST00000310645.5_Silent_p.V752V|COL6A2_ENST00000357838.4_Silent_p.V752V	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	752	Nonhelical region.|VWFA 2.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACCGCGACGTCACAGTGACGG	0.627000													57	153					9.59449e-18	9.6511e-18	1	1	0
FPR1	2357	broad.mit.edu	37	19	52250002	52250002	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52250002C>T	ENST00000595042.1	-	3	387	c.246G>A	c.(244-246)atG>atA	p.M82I	FPR1_ENST00000304748.4_Missense_Mutation_p.M82I	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	82					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CCTTCCTGACCATGAAGAATG	0.517000													15	91					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043328	117043328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117043328G>A	ENST00000371876.1	-	4	3570	c.1149C>T	c.(1147-1149)ttC>ttT	p.F383F	KLHL13_ENST00000371882.1_Silent_p.F383F|KLHL13_ENST00000539496.1_Silent_p.F437F|KLHL13_ENST00000262820.3_Silent_p.F434F|KLHL13_ENST00000540167.1_Silent_p.F418F|KLHL13_ENST00000545703.1_Silent_p.F392F|KLHL13_ENST00000541812.1_Silent_p.F418F|KLHL13_ENST00000371878.1_Silent_p.F383F|KLHL13_ENST00000469946.1_Silent_p.F383F			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	434					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CACTTAGGTGGAAGAAGGTGC	0.398000													18	16					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21328024	21328024	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21328024C>T	ENST00000313654.9	+	3	806	c.565_splice	c.e3+1	p.H189_splice	LAMA3_ENST00000399516.3_Splice_Site_p.H189_splice	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	189	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.H189N(2)		NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATATTTTGCTCGTAAGTAATC	0.373000													27	63					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94722800	94722800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94722800G>A	ENST00000304338.3	+	17	2023	c.1869G>A	c.(1867-1869)atG>atA	p.M623I		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	623						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						ATTGTAGAATGAAACTTTGCT	0.333000													16	25					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824694	54824694	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:54824694C>T	ENST00000243911.2	+	1	907	c.795C>T	c.(793-795)atC>atT	p.I265I		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	302					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			TGGTCCTCATCATCACCTGCC	0.562000													57	89					0	0	1	0	0
C17orf77	146723	broad.mit.edu	37	17	72588857	72588857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72588857C>T	ENST00000392620.1	+	3	1034	c.672C>T	c.(670-672)tcC>tcT	p.S224S	C17orf77_ENST00000328023.2_Silent_p.S224S	NM_152460.2	NP_689673.2	Q96MU5	CQ077_HUMAN	chromosome 17 open reading frame 77	224						extracellular region				breast(2)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11						TTGCCTCTTCCTGCCCTGGGC	0.572000													23	73					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3248121	3248121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3248121C>T	ENST00000217939.6	-	4	801	c.647G>A	c.(646-648)gGa>gAa	p.G216E		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	216						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCACGGATTTCCCTGCAAGTA	0.488000													5	9					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176948363	176948363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:176948363G>A	ENST00000308618.4	-	1	278	c.142C>T	c.(142-144)Cgc>Tgc	p.R48C		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	48						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GGGCTTAGGCGAGCCGGGTGC	0.607000													12	53					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152534253	152534253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152534253C>T	ENST00000427231.2	-	34	3802	c.3600G>A	c.(3598-3600)atG>atA	p.M1200I	NEB_ENST00000409198.1_Missense_Mutation_p.M1200I|NEB_ENST00000397345.3_Missense_Mutation_p.M1200I|NEB_ENST00000604864.1_Missense_Mutation_p.M1200I|NEB_ENST00000172853.10_Missense_Mutation_p.M1200I|NEB_ENST00000603639.1_Missense_Mutation_p.M1200I	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1200					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAATGCCTTTCATCCAGTTGT	0.463000													88	268					0	0	1	0	0
SERPINA13P	388007	broad.mit.edu	37	14	95109994	95109994	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95109994C>T	ENST00000469935.1	+	0	1031					NR_015340.1																						CTTCATCTTCCCCAACAGGGG	0.587000													11	26					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45392370	45392370	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45392370C>T	ENST00000389039.6	-	24	3447	c.3062G>A	c.(3061-3063)cGa>cAa	p.R1021Q	DUOX2_ENST00000603300.1_Missense_Mutation_p.R1021Q			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1021	Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TAGGAAGCCTCGCTGCATCTT	0.597000													9	46					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96031005	96031005	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96031005C>T	ENST00000297954.4	+	18	4010	c.4010C>T	c.(4009-4011)tCc>tTc	p.S1337F	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.S949F|WNK2_ENST00000349097.3_Missense_Mutation_p.S949F|WNK2_ENST00000395477.2_Missense_Mutation_p.S1337F|WNK2_ENST00000356055.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1337					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CCTCTAAGCTCCCTGCCGCCA	0.627000													8	32					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42045551	42045551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42045551G>A	ENST00000372584.1	-	3	5932	c.4918C>T	c.(4918-4920)Ccg>Tcg	p.P1640S	HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1640S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1640S|HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1640S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1640					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GAAACCCCCGGAAGGTTGGGG	0.493000													37	63					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35802491	35802491	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35802491G>A	ENST00000400441.3	-	3	285	c.286C>T	c.(286-288)Ccc>Tcc	p.P96S	MROH8_ENST00000441008.2_Missense_Mutation_p.P82S|MROH8_ENST00000217333.8_Missense_Mutation_p.P11S					maestro heat-like repeat family member 8																		TAGGCACAGGGGATCACTACT	0.393000													9	26					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127253907	127253907	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127253907G>A	ENST00000341640.2	-	4	646	c.441C>T	c.(439-441)ccC>ccT	p.P147P	PAX4_ENST00000463946.1_Silent_p.P145P|PAX4_ENST00000338516.3_Silent_p.P155P|PAX4_ENST00000378740.2_Silent_p.P147P	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	155					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						AGCCACTATGGGGAGTGAGGA	0.562000													13	51					0	0	1	0	0
INTS4P2	644619	broad.mit.edu	37	7	65160108	65160108	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:65160108G>A	ENST00000430126.2	+	0	1278																											GACCCTCAGGGAGCCCAGGAG	0.507000													9	26					0	0	1	0	0
DDX42	11325	broad.mit.edu	37	17	61877952	61877952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61877952C>T	ENST00000578681.1	+	7	1197	c.596C>T	c.(595-597)cCt>cTt	p.P199L	DDX42_ENST00000583590.1_Missense_Mutation_p.P199L|DDX42_ENST00000457800.2_Missense_Mutation_p.P199L|DDX42_ENST00000359353.5_Missense_Mutation_p.P80L|DDX42_ENST00000389924.2_Missense_Mutation_p.P199L	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	199					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						ATCATTGATCCTCTTCCCCCC	0.388000													58	119					0	0	1	0	0
TSHR	7253	broad.mit.edu	37	14	81610660	81610660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81610660G>A	ENST00000541158.2	+	11	2580	c.2258G>A	c.(2257-2259)gGc>gAc	p.G753D	TSHR_ENST00000298171.2_Missense_Mutation_p.G753D|RP11-114N19.3_ENST00000557775.1_RNA			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	753					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	AAGAAGCAAGGCCAAATCTCA	0.403000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						34	99					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042515	74042515	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74042515C>T	ENST00000409561.1	+	3	1286	c.1165C>T	c.(1165-1167)Cct>Tct	p.P389S		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	389										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TCCACTACTTCCTGTAGAAAT	0.423000													7	49					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65185747	65185747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:65185747G>A	ENST00000358691.5	-	11	988	c.822C>T	c.(820-822)acC>acT	p.T274T	HELZ_ENST00000580168.1_Silent_p.T274T	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GGGATTTTTTGGTGCTGACAG	0.353000													46	126					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55223733	55223733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55223733G>A	ENST00000340465.2	+	6	835	c.749G>A	c.(748-750)aGa>aAa	p.R250K		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	250						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CGTGTGACTAGAAAGTGCCAT	0.378000													31	73					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167626901	167626901	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167626901C>T	ENST00000519204.1	+	16	2950	c.2832C>T	c.(2830-2832)tcC>tcT	p.S944S	TENM2_ENST00000403607.2_Silent_p.S889S|TENM2_ENST00000545108.1_Silent_p.S1065S|TENM2_ENST00000518659.1_Silent_p.S1065S|TENM2_ENST00000520394.1_Silent_p.S833S					teneurin transmembrane protein 2																		TCCCTGGTTCCAATGTGAAAC	0.493000													16	193					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48133933	48133933	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48133933C>T	ENST00000405493.2	-	23	2447	c.2238G>A	c.(2236-2238)gaG>gaA	p.E746E	RAPGEF3_ENST00000549151.1_Silent_p.E746E|RAPGEF3_ENST00000548919.1_Silent_p.E679E|RAPGEF3_ENST00000389212.3_Silent_p.E788E|RAPGEF3_ENST00000171000.4_Silent_p.E746E|RP1-197B17.3_ENST00000547799.1_lincRNA|RAPGEF3_ENST00000449771.2_Silent_p.E788E	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	746					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CCAGCAGCCTCTCGAGGGCGG	0.657000													3	15					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23827677	23827677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23827677C>T	ENST00000354639.3	+	21	2961	c.2497C>T	c.(2497-2499)Cat>Tat	p.H833Y	STK31_ENST00000433467.2_Missense_Mutation_p.H856Y|STK31_ENST00000355870.3_Missense_Mutation_p.H856Y|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Missense_Mutation_p.H833Y	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	856	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TGGATCACTTCATCAGAACAA	0.353000													47	82					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167184964	167184964	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167184964C>T	ENST00000476257.1	-	4	655	c.357G>A	c.(355-357)gtG>gtA	p.V119V	SERPINI2_ENST00000471111.1_Silent_p.V119V|SERPINI2_ENST00000264677.4_Silent_p.V119V|SERPINI2_ENST00000461846.1_Silent_p.V119V			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	119					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						ACTGTTCTTTCACAGTGAATC	0.368000													33	75					0	0	1	0	0
FLJ33360	401172	broad.mit.edu	37	5	6337369	6337369	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:6337369G>A	ENST00000507444.1	-	0	36					NR_028351.1																						GCTCACTTACGGCCCCCAGCA	0.537000													12	20					0	0	1	0	0
CASD1	64921	broad.mit.edu	37	7	94146881	94146881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94146881C>T	ENST00000297273.4	+	2	430	c.143C>T	c.(142-144)tCg>tTg	p.S48L		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	48						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			GGCAATGATTCGTGTGAATAC	0.338000													20	73					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175048623	175048623	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175048623C>T	ENST00000239462.4	+	3	677	c.564C>T	c.(562-564)tgC>tgT	p.C188C		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	188	EGF-like 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCTGCCTGTGCCATGAGCCCT	0.746000													5	8					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90857667	90857667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:90857667C>T	ENST00000394980.1	+	7	3155	c.2836C>T	c.(2836-2838)Cct>Tct	p.P946S	MMRN1_ENST00000508372.1_Missense_Mutation_p.P688S|MMRN1_ENST00000264790.2_Missense_Mutation_p.P946S|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	946					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TGCTACCATCCCTAAGTGGAT	0.363000													21	60					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42540356	42540356	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42540356G>A	ENST00000433992.1	-	0	220				CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						CAGTGGCAGGGGACCTGGCGG	0.647000													8	14					0	0	1	0	0
OR10V1	390201	broad.mit.edu	37	11	59480873	59480873	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59480873G>A	ENST00000307552.2	-	1	464	c.446C>T	c.(445-447)tCc>tTc	p.S149F		NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						CAGCACCAAGGAGCCTACCAG	0.498000													13	29					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277282	114277282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114277282C>T	ENST00000357077.4	+	38	7561	c.7508C>T	c.(7507-7509)gCc>gTc	p.A2503V	ANK2_ENST00000264366.6_Missense_Mutation_p.A2470V|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2470					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACGGAAGTGGCCTCTGTGCGG	0.537000													24	108					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134627736	134627736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134627736G>A	ENST00000368586.5	-	54	7408	c.7308C>T	c.(7306-7308)atC>atT	p.I2436I	TTC40_ENST00000263170.5_Silent_p.I597I	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	597										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						TGTCTTGGGTGATGGAGACAG	0.562000													13	22					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135698623	135698623	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135698623G>A	ENST00000298545.3	-	9	1379	c.858C>T	c.(856-858)gcC>gcT	p.A286A	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	286	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						GGGCCAGGAGGGCGGCCTGCA	0.627000													61	104					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538849	55538849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55538849C>T	ENST00000220676.1	+	4	2555	c.2407C>T	c.(2407-2409)Cct>Tct	p.P803S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	803					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TAAAGTGTTTCCTCACAATGA	0.299000													20	43					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32053653	32053653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32053653G>A	ENST00000375244.3	-	7	3223	c.3022C>T	c.(3022-3024)Ctg>Ttg	p.L1008L	TNXB_ENST00000375247.2_Silent_p.L1008L			P22105	TENX_HUMAN	tenascin XB	1095	Fibronectin type-III 2.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCCCCTGGCAGCACTTCCTCA	0.677000													27	54					0	0	1	0	0
BATF2	116071	broad.mit.edu	37	11	64756878	64756878	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64756878G>A	ENST00000301887.4	-	3	678	c.548C>T	c.(547-549)tCc>tTc	p.S183F	BATF2_ENST00000527716.1_Missense_Mutation_p.S159F|BATF2_ENST00000435842.2_Missense_Mutation_p.S98F	NM_138456.3	NP_612465.3	Q8N1L9	BATF2_HUMAN	basic leucine zipper transcription factor, ATF-like 2	183						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|skin(1)	9						CTGCAGGCTGGAACCAGTGTG	0.657000													11	30					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16736518	16736518	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16736518C>T	ENST00000335496.1	-	6	647	c.165G>A	c.(163-165)gaG>gaA	p.E55E	SPATA21_ENST00000540400.1_Silent_p.E32E|SPATA21_ENST00000466212.1_5'UTR	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	55							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		GCTCCCGCCTCTCTCCAATGT	0.652000													16	27					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21331581	21331581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21331581G>A	ENST00000256958.2	+	6	649	c.553G>A	c.(553-555)Gag>Aag	p.E185K		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	185					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TGGAATAGGGGAGACTCCCAT	0.348000													37	114					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53721836	53721836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:53721836G>A	ENST00000262135.4	-	5	664	c.571C>T	c.(571-573)Ccc>Tcc	p.P191S	RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.P191S|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.P191S|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.P191S	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	191					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				GTAAACATGGGATGTGGAGTT	0.308000													17	168					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150696629	150696629	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150696629G>A	ENST00000335244.4	-	10	1330	c.1201C>T	c.(1201-1203)Ccc>Tcc	p.P401S	SLC36A2_ENST00000450886.1_Missense_Mutation_p.P125S	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	401					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCAGGCGGGGGATGAGGATG	0.582000													5	23					0	0	1	0	0
RAX	30062	broad.mit.edu	37	18	56939814	56939814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56939814C>T	ENST00000334889.3	-	2	508	c.322G>A	c.(322-324)Gag>Aag	p.E108K	RAX_ENST00000256852.7_Intron	NM_013435.2	NP_038463.2	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	108					visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E108K(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)		GGCCGTGCCTCCCCGGGCTCC	0.701000													17	57					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182392093	182392093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:182392093G>A	ENST00000397033.2	+	22	2839	c.2409G>A	c.(2407-2409)gaG>gaA	p.E803E		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	803					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GCATGGTGGAGAAAATGAACT	0.328000													23	62					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138163315	138163315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:138163315C>T	ENST00000409968.1	+	13	2811	c.2633C>T	c.(2632-2634)tCc>tTc	p.S878F	THSD7B_ENST00000272643.3_Missense_Mutation_p.S878F|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.S847F					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ACTGCTTGGTCCAAGTTTACG	0.502000													8	22					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131792975	131792975	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131792975G>A	ENST00000286355.5	-	18	5509	c.3417C>T	c.(3415-3417)atC>atT	p.I1139I	ADCY8_ENST00000377928.3_Silent_p.I1008I	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1139					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GGTCCTTCAGGATGAGATAGG	0.498000										HNSCC(32;0.087)			56	103					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294370	25294370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25294370G>A	ENST00000400358.4	+	19	2511	c.2454G>A	c.(2452-2454)agG>agA	p.R818R	SGSM1_ENST00000400359.4_Silent_p.R873R	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	873	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						AGGGCTGGAGGAGCAGCGAGA	0.592000													31	73					0	0	1	0	0
LRRN1	57633	broad.mit.edu	37	3	3887440	3887440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:3887440C>T	ENST00000319331.3	+	2	1876	c.1115C>T	c.(1114-1116)cCc>cTc	p.P372L	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	372	LRRCT.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CATAGCAATCCCCTCAGGTGT	0.488000													21	71					0	0	1	0	0
IL20RB	53833	broad.mit.edu	37	3	136728968	136728968	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:136728968C>T	ENST00000329582.4	+	7	1088	c.839C>T	c.(838-840)tCa>tTa	p.S280L	IL20RB_ENST00000309741.5_3'UTR	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	280						integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						ATAACCAATTCACCCCAGAAG	0.378000													45	112					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234878920	234878920	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234878920C>T	ENST00000324695.4	+	17	2245	c.2205C>T	c.(2203-2205)ttC>ttT	p.F735F	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	735						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CCTCCCCCTTCGTGGTCTTCT	0.547000													111	232					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162280207	162280207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:162280207C>T	ENST00000389554.3	+	6	1835	c.1518C>T	c.(1516-1518)ttC>ttT	p.F506F	TBR1_ENST00000410035.1_Silent_p.F219F	NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	506						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						CCACGGACTTCGCGGGCAACG	0.731000													3	7					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386636	56386636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56386636G>A	ENST00000355701.3	-	22	4867	c.3997C>T	c.(3997-3999)Ccg>Tcg	p.P1333S	BZRAP1_ENST00000268893.6_Missense_Mutation_p.P1273S|BZRAP1_ENST00000343736.4_Missense_Mutation_p.P1333S	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1333						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tcctcctccGGGATGCTAAAG	0.597000													16	46					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31159911	31159911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31159911G>A	ENST00000268281.4	-	5	416	c.358C>T	c.(358-360)Cgc>Tgc	p.R120C	PRSS36_ENST00000569305.1_Missense_Mutation_p.R120C|PRSS36_ENST00000418068.2_Missense_Mutation_p.R120C	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	120	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						GCCACTGCGCGGGTGTGCGCG	0.751000													16	34					0	0	1	0	0
TRAV8-1	28685	broad.mit.edu	37	14	22265871	22265871	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22265871C>T	ENST00000390430.2	+	0	286																											AACTGTTAATCTCTTCTGGTA	0.493000													11	118					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49932749	49932749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49932749G>A	ENST00000296474.3	-	14	3149	c.3122C>T	c.(3121-3123)tCc>tTc	p.S1041F	MST1R_ENST00000344206.4_Missense_Mutation_p.S992F	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	1041					cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TTCACTATCGGAGAAGGATGC	0.562000													45	108					0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53912393	53912393	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53912393G>A	ENST00000335754.3	-	3	496	c.396C>T	c.(394-396)tcC>tcT	p.S132S	ACTR8_ENST00000482349.1_Silent_p.S21S	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	132					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		CCTGTTCAGGGGACACAGGAA	0.363000													42	193					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62327271	62327271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62327271G>A	ENST00000371158.2	+	19	2485	c.2371G>A	c.(2371-2373)Gaa>Aaa	p.E791K	INADL_ENST00000316485.6_Missense_Mutation_p.E791K	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	791					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						AAGCAGTAATGAAGACAAGAC	0.274000													57	133					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	137028077	137028077	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:137028077G>A	ENST00000541417.1	-	3	610	c.68C>T	c.(67-69)aCt>aTt	p.T23I	KLHL3_ENST00000506491.1_Silent_p.D59D|KLHL3_ENST00000394937.3_Silent_p.D141D|KLHL3_ENST00000508657.1_Silent_p.D109D|KLHL3_ENST00000309755.4_Silent_p.D141D			Q9UH77	KLHL3_HUMAN	kelch-like family member 3	0						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		ACTGCAGGAAGTCACAGCAGT	0.552000													7	33					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61745770	61745770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:61745770G>A	ENST00000325324.6	+	4	425	c.256G>A	c.(256-258)Gag>Aag	p.E86K	IPO11_ENST00000409296.3_Missense_Mutation_p.E126K|KIF2A_ENST00000509663.2_Intron	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	86	Importin N-terminal.					cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		CTCAGAGGAGGAGAAAACTAC	0.328000													25	78					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46801051	46801051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46801051C>T	ENST00000230588.4	+	11	1394	c.1385C>T	c.(1384-1386)tCg>tTg	p.S462L		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	462	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding	p.S462*(1)		NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			TTCTACAATTCGGAGGGATAT	0.502000													7	98					0	0	1	0	0
ALG8	79053	broad.mit.edu	37	11	77812146	77812146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:77812146G>A	ENST00000299626.5	-	13	1516	c.1445C>T	c.(1444-1446)tCc>tTc	p.S482F	ALG8_ENST00000376156.3_3'UTR	NM_024079.4	NP_076984.2	Q9BVK2	ALG8_HUMAN	ALG8, alpha-1,3-glucosyltransferase	482					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	30	all_cancers(14;3.62e-19)|all_epithelial(13;1.27e-21)|Breast(9;8.51e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;9.66e-25)			CACCTTCCAGGAGGTGAAAGG	0.423000													28	89					0	0	1	0	0
SPC25	57405	broad.mit.edu	37	2	169730139	169730139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169730139G>A	ENST00000282074.2	-	6	647	c.506C>T	c.(505-507)cCa>cTa	p.P169L		NM_020675.3	NP_065726.1	Q9HBM1	SPC25_HUMAN	SPC25, NDC80 kinetochore complex component	169	Interaction with the C-terminus of SPBC24.				cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	9						AAACATAAATGGGCTCTCAGG	0.338000													29	153					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018713	62018713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62018713G>A	ENST00000578147.1	-	24	5005	c.4929C>T	c.(4927-4929)ttC>ttT	p.F1643F	SCN4A_ENST00000435607.1_Silent_p.F1643F			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1643					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GGGTGTCCACGAAGTCTGAGA	0.567000													19	62					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179604914	179604914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179604914C>T	ENST00000444136.1	+	9	1662	c.1412C>T	c.(1411-1413)tCc>tTc	p.S471F	TDRD5_ENST00000367614.1_Missense_Mutation_p.S471F|TDRD5_ENST00000294848.8_Missense_Mutation_p.S471F	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	471					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GACACCAGTTCCCTCATAGGG	0.453000													21	70					0	0	1	0	0
RNF8	9025	broad.mit.edu	37	6	37328278	37328278	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:37328278C>T	ENST00000373479.4	+	2	361	c.168C>T	c.(166-168)ccC>ccT	p.P56P	RNF8_ENST00000394443.4_Silent_p.P56P|RNF8_ENST00000469731.1_Silent_p.P56P|RNF8_ENST00000479516.1_3'UTR	NM_003958.3|NM_183078.2	NP_003949.1|NP_898901.1	O76064	RNF8_HUMAN	ring finger protein 8, E3 ubiquitin protein ligase	56	FHA.				cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	13						AAATCTGCCCCCTGATGATTT	0.443000													25	82					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7712089	7712089	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7712089C>T	ENST00000441779.2	+	17	1564	c.1527C>T	c.(1525-1527)ttC>ttT	p.F509F	STXBP2_ENST00000414284.2_Silent_p.F495F|STXBP2_ENST00000221283.5_Silent_p.F498F|STXBP2_ENST00000602355.1_Silent_p.F33F	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	498					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						TGTGGCCCTTCGTATCCGACC	0.736000													20	54					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25684939	25684939	+	Missense_Mutation	SNP	C	C	T	rs141199449		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25684939C>T	ENST00000376351.3	+	3	1467	c.1108C>T	c.(1108-1110)Cgg>Tgg	p.R370W		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	370						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GAACAACTTTCGGAGTAAGTG	0.358000													12	35					0	0	1	0	0
STK38	11329	broad.mit.edu	37	6	36492232	36492232	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36492232G>A	ENST00000229812.7	-	4	477	c.192C>T	c.(190-192)ctC>ctT	p.L64L		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	64	Interaction with S100B.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTGATCTCCGGAGTCGTTTCT	0.393000													28	72					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170965663	170965663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:170965663C>T	ENST00000367759.4	+	14	1507	c.1353C>T	c.(1351-1353)gcC>gcT	p.A451A	MROH9_ENST00000367758.3_Silent_p.A451A	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		CCCAGGATGCCCTGAGAGTTC	0.418000													30	86					0	0	1	0	0
MEIS1	4211	broad.mit.edu	37	2	66795861	66795861	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:66795861C>T	ENST00000488550.1	+	11	1386	c.1087C>T	c.(1087-1089)Cag>Tag	p.Q363*	MEIS1_ENST00000444274.2_3'UTR|MEIS1_ENST00000495021.2_Nonsense_Mutation_p.Q298*|MEIS1_ENST00000272369.9_Nonsense_Mutation_p.Q363*|MEIS1_ENST00000398506.2_Nonsense_Mutation_p.Q361*|MEIS1_ENST00000407092.2_Nonsense_Mutation_p.Q363*|MEIS1_ENST00000409517.1_3'UTR			O00470	MEIS1_HUMAN	Meis homeobox 1	363	Required for transcriptional activation (By similarity).						sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						AATGGACGGTCAGCAACATAT	0.408000													52	199					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56094424	56094424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56094424C>T	ENST00000426658.2	-	3	1425	c.764G>A	c.(763-765)gGa>gAa	p.G255E	CTCFL_ENST00000429804.2_Missense_Mutation_p.G255E|CTCFL_ENST00000422869.2_Missense_Mutation_p.G255E|CTCFL_ENST00000422109.2_Missense_Mutation_p.G255E|CTCFL_ENST00000423479.2_Missense_Mutation_p.G255E|CTCFL_ENST00000481655.1_5'UTR|CTCFL_ENST00000371196.2_Missense_Mutation_p.G255E|CTCFL_ENST00000243914.3_Missense_Mutation_p.G255E|CTCFL_ENST00000539382.1_Missense_Mutation_p.G50E|CTCFL_ENST00000432255.2_Missense_Mutation_p.G255E|CTCFL_ENST00000433949.2_Missense_Mutation_p.G255E|CTCFL_ENST00000502686.2_5'UTR			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	255					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GTGGAAGGTTCCTTTTGCTCC	0.378000													63	137					0	0	1	0	0
ASB17	127247	broad.mit.edu	37	1	76397607	76397607	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:76397607C>T	ENST00000284142.6	-	1	509	c.370G>A	c.(370-372)Gac>Aac	p.D124N		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	124					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						CAACTTCTGTCTTGAACATAG	0.338000													6	47					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87724972	87724972	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:87724972G>A	ENST00000436978.1	+	43	7111	c.6631G>A	c.(6631-6633)Ggt>Agt	p.G2211S	PTPN13_ENST00000316707.6_Missense_Mutation_p.G2015S|PTPN13_ENST00000411767.2_Missense_Mutation_p.G2206S|PTPN13_ENST00000511467.1_Missense_Mutation_p.G2211S|PTPN13_ENST00000427191.2_Missense_Mutation_p.G2187S	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2206						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AGTCCTGCGGGGTTTGCTAGA	0.458000													12	158					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128150761	128150761	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:128150761C>T	ENST00000368250.1	-	4	830	c.332G>A	c.(331-333)tGg>tAg	p.W111*	THEMIS_ENST00000537166.1_Nonsense_Mutation_p.W155*|THEMIS_ENST00000368248.2_Nonsense_Mutation_p.W190*|THEMIS_ENST00000543064.1_Nonsense_Mutation_p.W190*			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	190	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						AGGAATCTTCCATTCAACAAT	0.353000													33	48					0	0	1	0	0
TLR10	81793	broad.mit.edu	37	4	38775563	38775563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:38775563G>A	ENST00000308973.4	-	4	2254	c.1649C>T	c.(1648-1650)tCa>tTa	p.S550L	TLR10_ENST00000506111.1_Missense_Mutation_p.S550L|TLR10_ENST00000508334.1_Missense_Mutation_p.S550L|TLR10_ENST00000361424.2_Missense_Mutation_p.S550L	NM_001017388.2|NM_001195107.1|NM_030956.3	NP_001017388.1|NP_001182036.1|NP_112218.2	Q9BXR5	TLR10_HUMAN	toll-like receptor 10	550	LRRCT.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(2)	25						ACAGGTGTATGAATCTGACCA	0.393000													32	98					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19375254	19375254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19375254G>A	ENST00000263208.5	-	11	1349	c.1093C>T	c.(1093-1095)Ccc>Tcc	p.P365S	HIRA_ENST00000541063.1_Missense_Mutation_p.P321S|HIRA_ENST00000546308.1_Missense_Mutation_p.P321S|HIRA_ENST00000340170.4_Missense_Mutation_p.P365S	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	365					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					TCGCTCAGGGGATCGCCAAGC	0.572000													9	23					0	0	1	0	0
DUPD1	338599	broad.mit.edu	37	10	76797674	76797674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76797674C>T	ENST00000338487.5	-	3	582	c.583G>A	c.(583-585)Gag>Aag	p.E195K		NM_001003892.1	NP_001003892.1	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase domain containing 1	195	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TTGTCCAGCTCCCGGAGCTGC	0.647000													36	56					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197183412	197183412	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197183412C>T	ENST00000260983.2	-	9	2384	c.2202G>A	c.(2200-2202)ggG>ggA	p.G734G	HECW2_ENST00000409111.1_Silent_p.G378G	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	734					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						GCCAGACCTCCCCCAGCTCCT	0.652000													14	32					0	0	1	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382208	41382208	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41382208C>T	ENST00000377801.3	-	2	606	c.532G>A	c.(532-534)Gaa>Aaa	p.E178K	PLCXD3_ENST00000328457.3_Missense_Mutation_p.E178K			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	178	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						AAACTAACTTCCTGGGCAAAA	0.448000													17	180					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158637664	158637664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158637664C>T	ENST00000368148.3	-	15	2202	c.2022G>A	c.(2020-2022)gaG>gaA	p.E674E	SPTA1_ENST00000368147.3_Silent_p.E674E	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	674					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTTTGTAGCCTCCAGCAACT	0.423000													20	51					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11364993	11364993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:11364993C>T	ENST00000304623.8	-	8	1376	c.1187G>A	c.(1186-1188)cGa>cAa	p.R396Q	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_5'UTR|CTNND2_ENST00000511377.1_Missense_Mutation_p.R305Q|CTNND2_ENST00000503622.1_Missense_Mutation_p.R59Q|CTNND2_ENST00000359640.2_Missense_Mutation_p.R396Q	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	396					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GTATGAGGCTCGGGAACCAGC	0.488000													10	41					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116975543	116975543	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116975543G>A	ENST00000355044.3	+	9	1563	c.1437G>A	c.(1435-1437)aaG>aaA	p.K479K		NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	479						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAATAACAAAGTCCATTTATG	0.363000													25	62					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9864270	9864270	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:9864270C>T	ENST00000380913.3	+	4	2412	c.2322C>T	c.(2320-2322)ctC>ctT	p.L774L		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	774					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				AGGTGGGCCTCACGAGGGGCT	0.587000													15	8					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179525581	179525581	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:179525581C>T	ENST00000467460.1	-	14	1887	c.1557G>A	c.(1555-1557)gcG>gcA	p.A519A	PEX5L_ENST00000485199.1_Silent_p.A484A|PEX5L_ENST00000476138.1_Silent_p.A476A|PEX5L_ENST00000465751.1_Silent_p.A495A|PEX5L_ENST00000472994.1_Silent_p.A460A|PEX5L_ENST00000468741.1_Silent_p.A327A|PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000464614.1_Silent_p.A411A|PEX5L_ENST00000392649.3_Silent_p.A411A|PEX5L_ENST00000263962.8_Silent_p.A517A	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	519					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GGTCTCCGTTCGCCAAGGTCG	0.527000													14	202					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13936915	13936915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:13936915C>T	ENST00000294489.6	+	3	804	c.463C>T	c.(463-465)Cgc>Tgc	p.R155C	PDPN_ENST00000487038.1_Missense_Mutation_p.R37C|PDPN_ENST00000376061.4_Missense_Mutation_p.R37C|PDPN_ENST00000513143.1_Missense_Mutation_p.R37C|PDPN_ENST00000475043.1_Missense_Mutation_p.R37C|PDPN_ENST00000376057.4_Missense_Mutation_p.R155C|PDPN_ENST00000509009.1_Missense_Mutation_p.R74C			Q86YL7	PDPN_HUMAN	podoplanin	79					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		AACAGGCATTCGCATCGAGGA	0.478000													36	93					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47921602	47921602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47921602G>A	ENST00000289672.2	-	20	3397	c.3347C>T	c.(3346-3348)cCc>cTc	p.P1116L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1116	REJ.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AGACAGGGAGGGGTCCACCAG	0.567000													23	62					0	0	1	0	0
ANKRD19P	138649	broad.mit.edu	37	9	95646896	95646896	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95646896C>T	ENST00000473204.1	+	0	2247				RP11-526D8.7_ENST00000446878.1_RNA																							GACCTGCTTTCACAACTGCAG	0.607000													44	125					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137712030	137712030	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137712030C>T	ENST00000371817.3	+	58	4929	c.4515C>T	c.(4513-4515)ctC>ctT	p.L1505L		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1505	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ACCGTGGTCTCCCTGGCCCCC	0.602000													20	53					0	0	1	0	0
APOA2	336	broad.mit.edu	37	1	161193180	161193180	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161193180G>A	ENST00000367990.3	-	2	69	c.12C>T	c.(10-12)ctC>ctT	p.L4L	APOA2_ENST00000481413.1_5'UTR	NM_001643.1	NP_001634.1	P02652	APOA2_HUMAN	apolipoprotein A-II	4					cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(2)|skin(2)	6	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAGTTGCTGCGAGCAGCTTCA	0.572000													7	24					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159166008	159166008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:159166008C>T	ENST00000283233.5	-	9	1360	c.1047G>A	c.(1045-1047)atG>atA	p.M349I	CCDC148_ENST00000536771.1_Missense_Mutation_p.M263I|CCDC148_ENST00000409187.1_Missense_Mutation_p.M358I	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	349										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						ACATGCTCTCCATTTCATGTG	0.403000													9	77					0	0	1	0	0
POLR1C	9533	broad.mit.edu	37	6	43484866	43484866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43484866G>A	ENST00000372389.3	+	1	107	c.19G>A	c.(19-21)Gtg>Atg	p.V7M	POLR1C_ENST00000304004.3_Missense_Mutation_p.V7M|POLR1C_ENST00000372344.2_Missense_Mutation_p.V7M	NM_203290.2	NP_976035.1	O15160	RPAC1_HUMAN	polymerase (RNA) I polypeptide C, 30kDa	7					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			TTCTCAGGCGGTGGAGGAAAT	0.612000													30	98					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41165464	41165464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41165464C>T	ENST00000380588.4	+	8	1155	c.1052C>T	c.(1051-1053)aCc>aTc	p.T351I		NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	351						integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				GTTGCAGACACCGCTTCTCTC	0.418000													35	114					0	0	1	0	0
BACE2	25825	broad.mit.edu	37	21	42647492	42647492	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:42647492C>T	ENST00000330333.6	+	9	1961	c.1498C>T	c.(1498-1500)Ccc>Tcc	p.P500S	BACE2_ENST00000347667.4_Missense_Mutation_p.P450S|BACE2_ENST00000328735.6_3'UTR|BACE2_ENST00000466122.1_3'UTR	NM_012105.3	NP_036237.2	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2	500					membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				TCAGCGTCGCCCCCGTGACCC	0.542000													9	47					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160604751	160604751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160604751C>T	ENST00000259050.3	+	5	1072	c.950C>T	c.(949-951)tCt>tTt	p.S317F	MARCH7_ENST00000409591.1_Missense_Mutation_p.S279F|MARCH7_ENST00000539065.1_Missense_Mutation_p.S261F|MARCH7_ENST00000409175.1_Missense_Mutation_p.S317F	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	317	Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						TCTTACGTTTCTCCAAGAATC	0.393000													29	45					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64639846	64639846	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:64639846C>T	ENST00000587624.1	+	0	729																											CCGAGAAGATCAGCTTGACAC	0.453000													18	64					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173942648	173942648	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:173942648G>A	ENST00000506823.1	+	12	2167	c.1510G>A	c.(1510-1512)Gaa>Aaa	p.E504K	GALNTL6_ENST00000508122.1_Missense_Mutation_p.E487K	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	504	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.?(1)		breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						TGGATGGAGAGAAGATATTCG	0.478000													27	121					0	0	1	0	0
SYN2	6854	broad.mit.edu	37	3	12211262	12211262	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:12211262G>A	ENST00000432424.2	+	0	1336							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						ACCAGGTCATGGACTGTAGCA	0.512000													14	38					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108754254	108754254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108754254C>T	ENST00000232603.5	-	15	1474	c.1392G>A	c.(1390-1392)gaG>gaA	p.E464E	MORC1_ENST00000483760.1_Silent_p.E464E	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	464					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTAAAGGTTTCTCCACATCGA	0.299000													8	54					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102826412	102826412	+	Missense_Mutation	SNP	G	G	A	rs2276093	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102826412G>A	ENST00000260302.3	-	1	51	c.23C>T	c.(22-24)gCc>gTc	p.A8V	MMP13_ENST00000340273.4_Missense_Mutation_p.A8V	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	8					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GAAGAGGAAGGCAGCCAGGAC	0.517000													19	75					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921215	24921215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24921215C>T	ENST00000329468.2	+	1	675	c.201C>T	c.(199-201)gcC>gcT	p.A67A		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TCTTCGTCGCCCCTAAGAGGC	0.716000													8	35					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85448657	85448657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:85448657G>A	ENST00000316356.4	-	5	996	c.432C>T	c.(430-432)tcC>tcT	p.S144S	SYTL2_ENST00000528231.1_Silent_p.S144S|SYTL2_ENST00000389960.4_Silent_p.S144S|SYTL2_ENST00000524452.1_Silent_p.S144S|SYTL2_ENST00000527523.1_Silent_p.S96S			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	144					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGTTTTCCTGGGACATATCAA	0.373000													10	49					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54604082	54604082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54604082C>T	ENST00000474759.1	+	8	887	c.839C>T	c.(838-840)tCa>tTa	p.S280L	CACNA2D3_ENST00000415676.2_Missense_Mutation_p.S280L|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.S280L|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.S186L	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	280	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CAAACAGTCTCATCCATTTTG	0.448000													54	117					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15831419	15831419	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:15831419C>T	ENST00000338282.6	-	25	3286	c.3180G>A	c.(3178-3180)ctG>ctA	p.L1060L	MYH11_ENST00000300036.5_Silent_p.L1060L|MYH11_ENST00000452625.2_Silent_p.L1067L|MYH11_ENST00000396324.3_Silent_p.L1067L|MYH11_ENST00000576790.1_Silent_p.L1060L	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1060					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CATCACCCTCCAGCTTCCGTT	0.587000			T	CBFB	AML								22	75					0	0	1	0	0
TBC1D8	11138	broad.mit.edu	37	2	101656712	101656712	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:101656712G>A	ENST00000409318.1	-	6	1138	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	TBC1D8_ENST00000376840.4_Silent_p.F321F	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	321	GRAM 2.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						TGTCAGAGGCGAACATCCGCC	0.582000													22	47					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128482972	128482972	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128482972G>A	ENST00000325888.8	+	16	2775	c.2514G>A	c.(2512-2514)gcG>gcA	p.A838A	FLNC_ENST00000346177.6_Silent_p.A838A	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	838					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CACCAGGGGCGGGCCGCTACA	0.592000													5	47					0	0	1	0	0
MSRB3	253827	broad.mit.edu	37	12	65847522	65847522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:65847522C>T	ENST00000308259.5	+	6	581	c.307C>T	c.(307-309)Cac>Tac	p.H103Y	MSRB3_ENST00000535664.1_Missense_Mutation_p.H103Y|MSRB3_ENST00000540804.1_Missense_Mutation_p.H110Y|MSRB3_ENST00000355192.3_Missense_Mutation_p.H110Y	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	110					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		GCCTTCATTCCACGATGTGAT	0.448000													27	58					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133948017	133948017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133948017G>A	ENST00000220616.4	+	25	4989	c.4949G>A	c.(4948-4950)gGg>gAg	p.G1650E	TG_ENST00000377869.1_Missense_Mutation_p.G1593E|TG_ENST00000542445.1_Missense_Mutation_p.G84E	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1650					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GATGCACTGGGGAACTCAAAG	0.448000													15	43					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42474456	42474456	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42474456G>A	ENST00000545399.1	-	18	2615	c.2462C>T	c.(2461-2463)cCt>cTt	p.P821L	ATP1A3_ENST00000602133.1_Missense_Mutation_p.P778L|ATP1A3_ENST00000543770.1_Missense_Mutation_p.P819L|ATP1A3_ENST00000302102.5_Missense_Mutation_p.P808L	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	808					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						TGAGATGGCAGGGACCTAGGC	0.632000													15	36					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841951	94841951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94841951G>A	ENST00000357742.4	+	1	457	c.457G>A	c.(457-459)Gag>Aag	p.E153K	MCTP2_ENST00000543482.1_Missense_Mutation_p.E153K|MCTP2_ENST00000451018.3_Missense_Mutation_p.E153K|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	153					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TGCACCAGAAGAGCCAGAGGT	0.532000													29	101					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230456417	230456417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:230456417G>A	ENST00000341772.4	-	2	598	c.464C>T	c.(463-465)cCt>cTt	p.P155L		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	155					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AGCAGGAACAGGCTGAAGCTG	0.552000													5	69					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117681165	117681165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117681165G>A	ENST00000317775.6	-	19	3584	c.2899C>T	c.(2899-2901)Cgc>Tgc	p.R967C	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.R1001C	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	967					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTCCAGCTGCGATCATTGCTG	0.512000													24	72					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37262227	37262227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37262227C>T	ENST00000310758.4	-	10	1420	c.773G>A	c.(772-774)aGg>aAg	p.R258K	ELMO1_ENST00000448602.1_Missense_Mutation_p.R258K|ELMO1_ENST00000442504.1_Missense_Mutation_p.R258K	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	258					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TACCTGCCTCCTCTCATCAGG	0.428000													19	79					0	0	1	0	0
SAMSN1	64092	broad.mit.edu	37	21	15893541	15893541	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:15893541C>T	ENST00000285670.2	-	3	437	c.261_splice	c.e3-1	p.R88_splice	SAMSN1_ENST00000400566.1_Splice_Site_p.R20_splice|SAMSN1_ENST00000400564.1_Intron	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	20					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		ACTGCTGCTTCGCTATAAAAT	0.303000													11	21					0	0	1	0	0
ZNF367	195828	broad.mit.edu	37	9	99160471	99160471	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:99160471G>A	ENST00000375256.4	-	2	842	c.546C>T	c.(544-546)ctC>ctT	p.L182L		NM_153695.3	NP_710162.1	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	182					regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(4)|large_intestine(3)|lung(3)|prostate(1)	12		Acute lymphoblastic leukemia(62;0.0167)				TGTGAGCCTGGAGCGATTTCT	0.358000													59	206					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046641	42046641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42046641G>A	ENST00000372584.1	-	3	4842	c.3828C>T	c.(3826-3828)tcC>tcT	p.S1276S	HIVEP3_ENST00000247584.5_Silent_p.S1276S|HIVEP3_ENST00000372583.1_Silent_p.S1276S|HIVEP3_ENST00000429157.2_Silent_p.S1276S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1276					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTGTGCTGGGGGAGAGGCCAG	0.612000													5	50					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7707367	7707367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7707367G>A	ENST00000441779.2	+	10	917	c.880G>A	c.(880-882)Gag>Aag	p.E294K	STXBP2_ENST00000414284.2_Missense_Mutation_p.E280K|STXBP2_ENST00000221283.5_Missense_Mutation_p.E283K	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	283					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						CTTGCTGGACGAGGACGATGA	0.662000													56	143					0	0	1	0	0
MAGEC2	51438	broad.mit.edu	37	X	141290858	141290858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:141290858G>A	ENST00000247452.3	-	3	1263	c.916C>T	c.(916-918)Cat>Tat	p.H306Y		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	306	MAGE.					cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					CTTTCTGAATGGGCTCTCGGA	0.468000										HNSCC(46;0.14)			39	39					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14306614	14306614	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:14306614G>A	ENST00000378053.3	-	2	1795	c.1539C>T	c.(1537-1539)ctC>ctT	p.L513L	MACROD2_ENST00000217246.4_Intron|FLRT3_ENST00000341420.4_Silent_p.L513L|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	513					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GCTCTCGATTGAGGGTGGTTG	0.468000													23	120					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39046462	39046462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:39046462C>T	ENST00000518318.2	+	1	55	c.13C>T	c.(13-15)Ctt>Ttt	p.L5F	POU6F2-AS2_ENST00000420243.1_RNA|POU6F2_ENST00000403058.1_Missense_Mutation_p.L5F			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	5					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						GAGTGCTCTTCTTCAGGTATT	0.348000													15	104					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53298740	53298740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53298740G>A	ENST00000552551.1	-	2	458	c.26C>T	c.(25-27)tCc>tTc	p.S9F	KRT8_ENST00000293308.6_Missense_Mutation_p.S9F|KRT8_ENST00000546897.1_Missense_Mutation_p.S9F|KRT8_ENST00000552150.1_Missense_Mutation_p.S37F			P05787	K2C8_HUMAN	keratin 8	9	Head.|Ser-rich.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTTGTAGGACTTCTGGGT	0.647000													10	17					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105367139	105367139	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:105367139C>T	ENST00000297581.2	+	3	1113	c.1064C>T	c.(1063-1065)tCc>tTc	p.S355F	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	355					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											CATGATTCTTCCTTTAATATA	0.333000													16	44					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44671797	44671797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44671797C>T	ENST00000454036.1	+	9	1217	c.1141C>T	c.(1141-1143)Ctc>Ttc	p.L381F	SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000243964.3_Missense_Mutation_p.L358F	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	381					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity	p.L358I(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CACAGAGAACCTCTGGAGCTC	0.607000													76	162					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803392	23803392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:23803392C>T	ENST00000264867.2	-	12	2373	c.2254G>A	c.(2254-2256)Gga>Aga	p.G752R	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	752	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TGCTTGCGTCCACAAAAGTAC	0.398000													8	49					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645491	45645491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:45645491C>T	ENST00000303230.4	-	2	702	c.645G>A	c.(643-645)atG>atA	p.M215I		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	215						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TTAAATAATTCATCTTGATCA	0.368000													16	59					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1260591	1260591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1260591C>T	ENST00000348261.5	+	20	4226	c.3978C>T	c.(3976-3978)gtC>gtT	p.V1326V	CACNA1H_ENST00000565831.1_Silent_p.V1326V|CACNA1H_ENST00000358590.4_Silent_p.V1326V	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1326					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGGAGCGGGTCTTCCTCAGCG	0.667000													7	28					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174291	150174291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150174291C>T	ENST00000307271.3	+	5	1995	c.1421C>T	c.(1420-1422)aCc>aTc	p.T474I		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	474						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAGCCAGTCACCAAGACCAGC	0.602000													22	43					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34051053	34051053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:34051053G>A	ENST00000382499.2	-	12	1528	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F	SYNJ1_ENST00000322229.7_Missense_Mutation_p.S471F|SYNJ1_ENST00000382491.3_Missense_Mutation_p.S474F|SYNJ1_ENST00000357345.3_Missense_Mutation_p.S471F|SYNJ1_ENST00000433931.2_Missense_Mutation_p.S510F	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	471	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						CTCTTGCTTGGAGCTGTCAAA	0.408000													21	94					0	0	1	0	0
ZFR2	23217	broad.mit.edu	37	19	3811344	3811344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3811344C>T	ENST00000262961.4	-	15	2273	c.2263G>A	c.(2263-2265)Gat>Aat	p.D755N		NM_015174.1	NP_055989.1	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2	755						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		TCACCTGCATCAGCCTGAGGC	0.642000													4	7					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178562985	178562985	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178562985C>T	ENST00000251582.7	-	13	2111	c.2010G>A	c.(2008-2010)atG>atA	p.M670I		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	670	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCATGCGCTTCATGGACACCA	0.647000													8	106					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111060798	111060798	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111060798G>A	ENST00000369771.2	-	1	999	c.612C>T	c.(610-612)ctC>ctT	p.L204L		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	204						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		ACTCAAAGAGGAGCCAGAACT	0.557000													20	56					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31538324	31538324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31538324C>T	ENST00000261592.5	-	7	1412	c.1115G>A	c.(1114-1116)gGa>gAa	p.G372E	NOL4_ENST00000269185.4_Missense_Mutation_p.G258E|NOL4_ENST00000535384.1_Missense_Mutation_p.G87E|NOL4_ENST00000535475.1_Missense_Mutation_p.G217E|NOL4_ENST00000589544.1_Missense_Mutation_p.G372E|NOL4_ENST00000538587.1_Missense_Mutation_p.G298E	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	372						nucleolus	RNA binding	p.G372A(1)		NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						GTCCTCAGCTCCTCGGTCTAC	0.463000													34	204					0	0	1	0	0
SEMA6C	10500	broad.mit.edu	37	1	151105853	151105853	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151105853G>A	ENST00000341697.3	-	19	3591	c.1900C>T	c.(1900-1902)Cga>Tga	p.R634*				Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	634						integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCCGACGTCGGTGGGCGCGG	0.726000													7	15					0	0	1	0	0
ADAMTSL2	9719	broad.mit.edu	37	9	136401900	136401900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136401900G>A	ENST00000393061.3	+	2	825	c.393G>A	c.(391-393)ggG>ggA	p.G131G	ADAMTSL2_ENST00000393060.1_Silent_p.G22G|ADAMTSL2_ENST00000354484.4_Silent_p.G22G			Q86TH1	ATL2_HUMAN	ADAMTS-like 2	22					negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(145;9.31e-08)|Epithelial(140;6.62e-07)|all cancers(34;7.74e-06)		TTGTAGCTGGGGACACAGTGT	0.602000													17	64					0	0	1	0	0
IFI27	3429	broad.mit.edu	37	14	94578120	94578120	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94578120G>A	ENST00000555744.1	+	2	279		c.e2+1		IFI27_ENST00000444961.1_Splice_Site|IFI27_ENST00000557634.1_Splice_Site|IFI27_ENST00000557098.1_Intron|IFI27_ENST00000298902.5_Splice_Site|IFI27_ENST00000448882.1_Splice_Site			P40305	IFI27_HUMAN	interferon, alpha-inducible protein 27						activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion				breast(1)|lung(3)	4				Epithelial(152;0.112)|all cancers(159;0.187)|COAD - Colon adenocarcinoma(157;0.206)		TTGCCCCTGGGTGAGTGTTCC	0.667000													14	48					0	0	1	0	0
PTGFRN	5738	broad.mit.edu	37	1	117504152	117504152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:117504152C>T	ENST00000393203.2	+	5	1648	c.1501C>T	c.(1501-1503)Cgg>Tgg	p.R501W		NM_020440.2	NP_065173.2	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor inhibitor	501	Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)	46	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GTTCAATTTCCGGATCCAAAG	0.483000													35	91					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98555693	98555693	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98555693C>T	ENST00000359863.4	+	43	6509	c.6300C>T	c.(6298-6300)ttC>ttT	p.F2100F	TRRAP_ENST00000355540.3_Silent_p.F2082F|TRRAP_ENST00000446306.3_Silent_p.F2081F	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	2100	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGTGAACTTCCTTATCCGCG	0.567000													12	33					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4832579	4832579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:4832579G>A	ENST00000378191.4	+	4	1538	c.1157G>A	c.(1156-1158)gGa>gAa	p.G386E	AJAP1_ENST00000378190.3_Missense_Mutation_p.G386E	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	386	Targeting signals.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		ACATTTAATGGAAACCGGTAA	0.602000													13	25					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34851459	34851459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34851459G>A	ENST00000360581.1	+	4	590	c.462G>A	c.(460-462)atG>atA	p.M154I	NPSR1_ENST00000381542.1_Intron|NPSR1_ENST00000381539.3_Missense_Mutation_p.M154I|NPSR1_ENST00000359791.1_Missense_Mutation_p.M154I|NPSR1_ENST00000531252.1_Missense_Mutation_p.M143I	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	154						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	TCTACCCCATGAAGTTCCTTC	0.458000													44	113					0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99513605	99513605	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:99513605G>A	ENST00000261037.3	+	5	1240	c.860G>A	c.(859-861)gGa>gAa	p.G287E	COL8A1_ENST00000273342.4_Missense_Mutation_p.G287E	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	287	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						GGCCCCCTGGGAAAGCCAGGG	0.667000													9	32					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7673059	7673059	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7673059C>T	ENST00000446248.2	+	7	851	c.750C>T	c.(748-750)ttC>ttT	p.F250F	CAMSAP3_ENST00000160298.4_Silent_p.F223F	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	223	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						CCCCCTGCTTCCCGACGGTGA	0.667000													23	66					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176671814	176671814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176671814C>T	ENST00000367662.3	+	9	4472	c.3308C>T	c.(3307-3309)tCg>tTg	p.S1103L		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1103					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.S1103L(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGAGAAGCTTCGCCTCCTCTG	0.493000													24	80					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48389692	48389692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48389692C>T	ENST00000380518.3	-	9	784	c.620G>A	c.(619-621)gGa>gAa	p.G207E	COL2A1_ENST00000337299.6_Missense_Mutation_p.G138E	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	207	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TCCTCGAGGTCCCATGGGGCC	0.542000													31	62					0	0	1	0	0
NR5A1	2516	broad.mit.edu	37	9	127262851	127262851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127262851G>A	ENST00000373588.4	-	4	584	c.388C>T	c.(388-390)Ccg>Tcg	p.P130S		NM_004959.4	NP_004950.2	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	130					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			lung(1)|upper_aerodigestive_tract(1)	2						GGGGGCGGCGGGGGCACCCCC	0.701000													5	25					0	0	1	0	0
SERPINB11	89778	broad.mit.edu	37	18	61390475	61390475	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61390475G>A	ENST00000544088.1	+	0	1083				SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				GGATGTCAGCGAAGAGGGCAC	0.498000													10	53					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73462316	73462316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73462316C>T	ENST00000224721.6	+	23	2618	c.2613C>T	c.(2611-2613)ccC>ccT	p.P871P	CDH23_ENST00000299366.7_Silent_p.P911P	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	866	Cadherin 8.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GTGGCAGGCCCCCTCTGAAAG	0.567000													61	188					0	0	1	0	0
ADRB2	154	broad.mit.edu	37	5	148207537	148207537	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148207537C>T	ENST00000305988.4	+	1	1382	c.1143C>T	c.(1141-1143)ctC>ctT	p.L381L		NM_000024.5	NP_000015.1	P07550	ADRB2_HUMAN	adrenoceptor beta 2, surface	381					activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(3)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	GTGAAGACCTCCCAGGCACGG	0.483000													7	72					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85500354	85500354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:85500354C>T	ENST00000393217.2	+	15	3399	c.3338C>T	c.(3337-3339)tCt>tTt	p.S1113F		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1113										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CATGAATTGTCTCTTACTGGA	0.338000													25	83					0	0	1	0	0
TAL1	6886	broad.mit.edu	37	1	47685771	47685771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47685771G>A	ENST00000371883.3	-	4	1199	c.623C>T	c.(622-624)gCc>gTc	p.A208V	TAL1_ENST00000459729.1_5'UTR|TAL1_ENST00000294339.3_Missense_Mutation_p.A206V|TAL1_ENST00000371884.2_Missense_Mutation_p.A206V			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	206	Helix-loop-helix motif.				basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						CTCGGCAAAGGCCCCGTTCAC	0.557000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								19	51					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447993	24447993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24447993G>A	ENST00000270800.1	-	7	1065	c.1027C>T	c.(1027-1029)Ccc>Tcc	p.P343S		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	343						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		AGGATCTGGGGAGGTGGCACG	0.627000													30	61					0	0	1	0	0
ZNF569	148266	broad.mit.edu	37	19	37905027	37905027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37905027G>A	ENST00000316950.6	-	6	1090	c.533C>T	c.(532-534)tCa>tTa	p.S178L	ZNF569_ENST00000392150.2_Missense_Mutation_p.S19L|ZNF569_ENST00000392149.2_Missense_Mutation_p.S178L	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAAATGGGATGAGCTATTACC	0.353000													30	46					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29301113	29301113	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:29301113G>A	ENST00000378993.1	+	3	814	c.141G>A	c.(139-141)gaG>gaA	p.E47E	IL1RAPL1_ENST00000302196.4_Silent_p.E47E	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	47	Ig-like C2-type 1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TGGTGGGAGAGCCTGTTCGAA	0.393000													27	19					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158369140	158369140	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158369140G>A	ENST00000334438.1	-	1	116	c.117C>T	c.(115-117)atC>atT	p.I39I		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TGGCCACCAGGATTGTCAAGT	0.483000													24	36					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6189094	6189094	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6189094C>T	ENST00000262450.3	-	23	3522	c.3423G>A	c.(3421-3423)aaG>aaA	p.K1141K	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1141	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TCATCACCTTCTTGTTCTGGC	0.647000													24	36					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75387345	75387345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:75387345C>T	ENST00000297784.5	+	13	1298	c.758C>T	c.(757-759)tCc>tTc	p.S253F	TMC1_ENST00000340019.3_Missense_Mutation_p.S253F|TMC1_ENST00000396237.3_Missense_Mutation_p.S253F	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	253					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						GCACAATATTCCGTTCTCTTT	0.383000													27	260					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256617	16256617	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16256617C>T	ENST00000375759.3	+	11	4086	c.3882C>T	c.(3880-3882)gtC>gtT	p.V1294V		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1294					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ATGAAAAAGTCCTCCCCTATT	0.428000													34	90					0	0	1	0	0
OLFM2	93145	broad.mit.edu	37	19	9971349	9971349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9971349C>T	ENST00000264833.4	-	2	370	c.185G>A	c.(184-186)aGt>aAt	p.S62N		NM_058164.2	NP_477512.1	O95897	NOE2_HUMAN	olfactomedin 2	62						extracellular region				breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	31						CAGCTCCCGACTCCTGCCATC	0.632000													3	11					0	0	1	0	0
TKTL1	8277	broad.mit.edu	37	X	153541044	153541044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153541044C>T	ENST00000369915.3	+	6	973	c.784C>T	c.(784-786)Ccc>Tcc	p.P262S	TKTL1_ENST00000217905.7_Intron|TKTL1_ENST00000369912.2_Missense_Mutation_p.P206S	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	262					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGACCCACAGCCCCCCATTGA	0.468000													36	27					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33144259	33144259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33144259G>A	ENST00000341947.2	-	27	2347	c.2120C>T	c.(2119-2121)cCc>cTc	p.P707L	COL11A2_ENST00000357486.1_Missense_Mutation_p.P686L|COL11A2_ENST00000361917.1_Missense_Mutation_p.P600L|COL11A2_ENST00000374708.4_Missense_Mutation_p.P621L|COL11A2_ENST00000395197.1_Missense_Mutation_p.P647L|COL11A2_ENST00000374712.1_Missense_Mutation_p.P626L|COL11A2_ENST00000374713.1_Missense_Mutation_p.P660L|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374714.1_Missense_Mutation_p.P681L	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	707	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						AGGTCCAGAGGGACCCTGGAA	0.547000													10	23					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149500563	149500563	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149500563G>A	ENST00000378016.2	+	0	7964							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATACTCCCAGGATGCCGCTGT	0.677000													12	38					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071252	9071252	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9071252G>A	ENST00000397910.4	-	3	16397	c.16194C>T	c.(16192-16194)atC>atT	p.I5398I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5400	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCATGAGTGATGCTGCTCA	0.507000													124	279					0	0	1	0	0
FRZB	2487	broad.mit.edu	37	2	183731065	183731065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:183731065G>A	ENST00000295113.4	-	1	825	c.216C>T	c.(214-216)ttC>ttT	p.F72F		NM_001463.3	NP_001454.2	Q92765	SFRP3_HUMAN	frizzled-related protein	72	FZ.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			GCAGACCTTCGAACTGCTCGA	0.602000													26	46					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79032165	79032165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:79032165G>A	ENST00000446378.2	+	2	7608	c.7577G>A	c.(7576-7578)aGa>aAa	p.R2526K		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2526						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TACAATGAAAGACCCAAAATC	0.378000													15	33					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583248	82583248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82583248C>T	ENST00000423517.2	-	5	7358	c.7021G>A	c.(7021-7023)Gat>Aat	p.D2341N	PCLO_ENST00000333891.8_Missense_Mutation_p.D2341N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2272	Poly-Pro.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGTGGGTGATCAAACACGGTT	0.423000													38	100					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152278822	152278822	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152278822G>A	ENST00000368799.1	-	3	8575	c.8540C>T	c.(8539-8541)tCa>tTa	p.S2847L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2847	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGTCTCCTGATTGTTCCTC	0.567000									Ichthyosis				114	779					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26242168	26242168	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26242168G>A	ENST00000335473.7	+	19	3720	c.3470G>A	c.(3469-3471)aGc>aAc	p.S1157N	MYO18B_ENST00000536101.1_Missense_Mutation_p.S1157N|MYO18B_ENST00000407587.2_Missense_Mutation_p.S1158N	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1157	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTGCAGAGGAGCCGCATGGTG	0.672000													12	32					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61508254	61508254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:61508254G>A	ENST00000398571.2	-	38	5198	c.5122C>T	c.(5122-5124)Cct>Tct	p.P1708S		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1708					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			TGAGCATCAGGAAGAAATTTC	0.388000													8	28					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9066520	9066520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9066520G>A	ENST00000397910.4	-	3	21129	c.20926C>T	c.(20926-20928)Ccc>Tcc	p.P6976S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6978	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTACCAGTGGGGACTTCTGAA	0.483000													59	112					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89979796	89979796	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89979796G>A	ENST00000405460.2	+	28	6154	c.6058G>A	c.(6058-6060)Gat>Aat	p.D2020N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2020					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AACACTAGATGATATGGAAAA	0.393000													15	43					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874347	36874347	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36874347G>A	ENST00000301807.6	-	21	6842	c.4945C>T	c.(4945-4947)Cct>Tct	p.P1649S	TRANK1_ENST00000429976.2_Missense_Mutation_p.P2199S|TRANK1_ENST00000428977.2_Missense_Mutation_p.P1649S	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2199					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AAGATTTTAGGGAATACTTTT	0.403000													18	43					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10545978	10545978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10545978G>A	ENST00000583535.1	-	16	1731	c.1644C>T	c.(1642-1644)tcC>tcT	p.S548S	MYH3_ENST00000226209.7_Silent_p.S548S	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	548	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TGTTCTTGAAGGAGGTGTCTG	0.512000													47	79					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49671965	49671965	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49671965G>A	ENST00000561648.1	-	4	1151	c.1098C>T	c.(1096-1098)tcC>tcT	p.S366S	ZNF423_ENST00000567169.1_Silent_p.S249S|ZNF423_ENST00000535559.1_Silent_p.S249S|ZNF423_ENST00000563137.2_Silent_p.S306S|ZNF423_ENST00000562520.1_Silent_p.S306S|ZNF423_ENST00000262383.2_Silent_p.S366S|ZNF423_ENST00000562871.1_Silent_p.S306S	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	366					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CGCTGCTCATGGAGGCCACGC	0.662000													4	26					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158623135	158623135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158623135G>A	ENST00000368148.3	-	22	3297	c.3117C>T	c.(3115-3117)ttC>ttT	p.F1039F	SPTA1_ENST00000368147.3_Silent_p.F1039F	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1039					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.F1039F(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGAGCATCGGGAACTCATCGT	0.562000													40	85					0	0	1	0	0
IL22RA2	116379	broad.mit.edu	37	6	137466765	137466765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:137466765G>A	ENST00000296980.2	-	7	1088	c.788C>T	c.(787-789)cCa>cTa	p.P263L	IL22RA2_ENST00000349184.4_Missense_Mutation_p.P231L|IL22RA2_ENST00000339602.3_3'UTR	NM_052962.2	NP_443194.1	Q969J5	I22R2_HUMAN	interleukin 22 receptor, alpha 2	263	Fibronectin type-III 3.				regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	interleukin-22 receptor activity			endometrium(1)|large_intestine(1)|lung(3)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000313)|OV - Ovarian serous cystadenocarcinoma(155;0.00407)		CACAAGTCATGGAATTTCCAC	0.403000													21	24					0	0	1	0	0
PAXIP1	22976	broad.mit.edu	37	7	154767930	154767930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:154767930G>A	ENST00000404141.1	-	6	704	c.550C>T	c.(550-552)Cgt>Tgt	p.R184C	PAXIP1_ENST00000397192.1_Missense_Mutation_p.R184C|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	184					DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		ATAATCAGACGAGGATGATAA	0.398000													8	38					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71709037	71709037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71709037C>T	ENST00000258104.3	+	3	450	c.173C>T	c.(172-174)cCc>cTc	p.P58L	DYSF_ENST00000394120.2_Missense_Mutation_p.P59L|DYSF_ENST00000409744.1_Missense_Mutation_p.P59L|DYSF_ENST00000410020.3_Missense_Mutation_p.P59L|DYSF_ENST00000413539.2_Missense_Mutation_p.P58L|DYSF_ENST00000429174.2_Missense_Mutation_p.P58L|DYSF_ENST00000409366.1_Missense_Mutation_p.P59L|DYSF_ENST00000409582.3_Missense_Mutation_p.P58L|DYSF_ENST00000409762.1_Missense_Mutation_p.P58L|DYSF_ENST00000409651.1_Missense_Mutation_p.P59L|DYSF_ENST00000410041.1_Missense_Mutation_p.P59L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	58	C2 1.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						AAGGGCATCCCCCTGGACCAG	0.537000													11	25					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59557575	59557575	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59557575G>A	ENST00000393853.4	+	8	1079	c.916G>A	c.(916-918)Gag>Aag	p.E306K	TBX4_ENST00000589449.1_3'UTR|TBX4_ENST00000240335.1_Missense_Mutation_p.E306K			P57082	TBX4_HUMAN	T-box 4	306					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CTACCAGCACGAGAACGGGGC	0.637000													57	98					0	0	1	0	0
UNC93B1	81622	broad.mit.edu	37	11	67766748	67766748	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67766748G>A	ENST00000227471.2	-	5	661	c.582C>T	c.(580-582)tcC>tcT	p.S194S	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	194					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome											CCTTGTAGTGGGAGTACTCAT	0.607000													13	22					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940198	68940198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:68940198G>A	ENST00000433211.1	-	7	1098	c.924C>T	c.(922-924)atC>atT	p.I308I	CTNNA3_ENST00000494580.1_5'UTR|CTNNA3_ENST00000545309.1_Silent_p.I308I|CTNNA3_ENST00000373744.4_Silent_p.I308I	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	308					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						CAGCCCCACTGATAATGGCTT	0.478000													25	60					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124399574	124399574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124399574G>A	ENST00000368909.3	+	52	6680	c.6574G>A	c.(6574-6576)Gac>Aac	p.D2192N	DMBT1_ENST00000330163.4_Missense_Mutation_p.D1564N|DMBT1_ENST00000368955.3_Missense_Mutation_p.D2182N|DMBT1_ENST00000359586.6_Missense_Mutation_p.D912N|DMBT1_ENST00000368956.2_Missense_Mutation_p.D1564N|DMBT1_ENST00000344338.3_Missense_Mutation_p.D2182N|DMBT1_ENST00000338354.3_Missense_Mutation_p.D2192N	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2192	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGACACCATCGACTATTCCAA	0.517000													19	40					0	0	1	0	0
KRT73	319101	broad.mit.edu	37	12	53009975	53009975	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53009975C>T	ENST00000305748.3	-	2	671	c.637G>A	c.(637-639)Gaa>Aaa	p.E213K		NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	213	Coil 1B.|Rod.					keratin filament	structural molecule activity	p.E213*(1)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCACCACTTCGCGCACGCTC	0.627000													27	127					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10263371	10263371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10263371C>T	ENST00000418404.3	-	6	714	c.551G>A	c.(550-552)gGg>gAg	p.G184E	MYH13_ENST00000570743.1_Missense_Mutation_p.G184E|MYH13_ENST00000252172.4_Missense_Mutation_p.G184E			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	184	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CACAGTCTTCCCAGCCCCGGA	0.493000													28	32					0	0	1	0	0
LRCH4	4034	broad.mit.edu	37	7	100179450	100179450	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100179450G>A	ENST00000310300.6	-	4	600	c.548C>T	c.(547-549)tCc>tTc	p.S183F	LRCH4_ENST00000497245.1_5'UTR	NM_002319.3	NP_002310.2	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 4	183					nervous system development	PML body	protein binding			NS(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	23	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GTCCCGCAGGGAAGAGAGGCC	0.587000													18	66					0	0	1	0	0
GPIHBP1	338328	broad.mit.edu	37	8	144297308	144297308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144297308C>T	ENST00000330824.2	+	4	545	c.470C>T	c.(469-471)cCc>cTc	p.P157L		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	157					cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GCAGGCGGCCCCCGGGGCAGC	0.687000													10	32					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6527210	6527210	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6527210C>T	ENST00000263125.5	-	10	1021	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K	PRKCQ_ENST00000397176.2_Missense_Mutation_p.E308K|PRKCQ_ENST00000539722.1_Missense_Mutation_p.E183K	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	308					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						AAGATCTGTTCAGTATCTCTT	0.507000													36	145					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784541	9784541	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9784541G>A	ENST00000304374.2	+	1	1284	c.888G>A	c.(886-888)aaG>aaA	p.K296K		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	296					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	AGGTTCTCAAGACCCTGTCGG	0.627000													11	99					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8531249	8531249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8531249C>T	ENST00000348943.3	+	8	876	c.644C>T	c.(643-645)tCc>tTc	p.S215F	HNRNPM_ENST00000325495.4_Missense_Mutation_p.S254F	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	254	RRM 2.				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						TTTGAACAGTCCATTGAAGCT	0.398000													51	137					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48614119	48614119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48614119G>A	ENST00000328333.8	-	67	5797	c.5690C>T	c.(5689-5691)cCt>cTt	p.P1897L	COL7A1_ENST00000454817.1_Intron	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1897	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGGCCAGGAGGGCCCACTGG	0.612000													4	8					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103063558	103063558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103063558C>T	ENST00000264260.2	+	10	1690	c.1101C>T	c.(1099-1101)acC>acT	p.T367T	IL18RAP_ENST00000409369.1_Silent_p.T225T	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	367					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TGCTTGGCACCATCGGGACCC	0.592000													81	226					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87591451	87591451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87591451C>T	ENST00000320005.5	-	16	1858	c.1811G>A	c.(1810-1812)cGa>cAa	p.R604Q		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	604					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						ATTGGCAGTTCGACGGTTTCC	0.423000													49	183					0	0	1	0	0
SLC22A16	85413	broad.mit.edu	37	6	110760036	110760036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110760036G>A	ENST00000368919.3	-	5	1264	c.1198C>T	c.(1198-1200)Ccc>Tcc	p.P400S	SLC22A16_ENST00000439654.1_Missense_Mutation_p.P400S|SLC22A16_ENST00000330550.4_Missense_Mutation_p.P366S	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	400					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		GTGTAGGCGGGAATTTCCACT	0.542000													23	28					0	0	1	0	0
ALDH1A3	220	broad.mit.edu	37	15	101436147	101436147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101436147C>T	ENST00000329841.5	+	7	1208	c.676C>T	c.(676-678)Cct>Tct	p.P226S	RP11-66B24.4_ENST00000560351.1_RNA|ALDH1A3_ENST00000346623.6_Missense_Mutation_p.P119S	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	226					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	GGCCGGGTTCCCTCCAGGAGT	0.557000													10	32					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746666	77746666	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:77746666C>T	ENST00000409088.3	-	3	743	c.329G>A	c.(328-330)aGa>aAa	p.R110K	LRRTM4_ENST00000409911.1_Missense_Mutation_p.R111K|LRRTM4_ENST00000409884.1_Missense_Mutation_p.R110K|LRRTM4_ENST00000409093.1_Missense_Mutation_p.R110K|LRRTM4_ENST00000409282.1_Missense_Mutation_p.R111K	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	110						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		TTCTTTCAGTCTACGGATCCC	0.388000													13	54					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156955916	156955916	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156955916G>T	ENST00000368194.3	-	2	1121	c.82C>A	c.(82-84)Cct>Act	p.P28T	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.P28T	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	28					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGTGGGAAGGGGACTTGCGC	0.532000													32	83					3.03874e-20	3.05762e-20	1	1	0
CST8	10047	broad.mit.edu	37	20	23476501	23476501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:23476501C>T	ENST00000246012.1	+	4	736	c.379C>T	c.(379-381)Ccc>Tcc	p.P127S		NM_005492.2	NP_005483.1	O60676	CST8_HUMAN	cystatin 8 (cystatin-related epididymal specific)	127						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(9)|skin(2)	16	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AGGAGCACTTCCCTGGAATGG	0.358000													14	150					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35406833	35406833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:35406833C>T	ENST00000287272.2	+	2	147	c.127C>T	c.(127-129)Ccc>Tcc	p.P43S	UNC5D_ENST00000416672.1_Missense_Mutation_p.P43S|UNC5D_ENST00000420357.1_Missense_Mutation_p.P43S|UNC5D_ENST00000404895.2_Missense_Mutation_p.P43S|UNC5D_ENST00000453357.2_Missense_Mutation_p.P38S			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	43					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CGAAGCCCTTCCCGAATCCAT	0.468000													6	68					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107096780	107096780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:107096780G>A	ENST00000261058.1	+	1	593	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	116										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						GAATGTTAATGAAGACAAACA	0.378000													19	43					0	0	1	0	0
PPP1R14D	54866	broad.mit.edu	37	15	41108451	41108451	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41108451C>T	ENST00000299174.5	-	2	323	c.255_splice	c.e2-1	p.D86_splice	PPP1R14D_ENST00000427255.2_Splice_Site_p.G124_splice	NM_017726.7	NP_060196.1	Q9NXH3	PP14D_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14D	86					regulation of phosphorylation	cytoplasm	protein phosphatase inhibitor activity			breast(1)|large_intestine(2)|lung(2)|skin(1)	6		all_cancers(109;6.29e-14)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.88e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GTTGCTTGATCCTATTTGGAA	0.527000													7	55					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14106581	14106581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:14106581C>T	ENST00000235372.7	+	8	3147	c.2291C>T	c.(2290-2292)aCc>aTc	p.T764I	PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000311066.5_Missense_Mutation_p.T764I|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.T563I|PRDM2_ENST00000343137.4_Missense_Mutation_p.T563I	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	764						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GCAGCATGGACCGATGCCGGG	0.517000													12	116					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19404516	19404516	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19404516G>A	ENST00000375267.2	-	104	15281	c.15278C>T	c.(15277-15279)tCc>tTc	p.S5093F	UBR4_ENST00000375224.1_Missense_Mutation_p.S800F|UBR4_ENST00000375225.3_Missense_Mutation_p.S168F|UBR4_ENST00000543981.1_Missense_Mutation_p.S757F|UBR4_ENST00000375226.2_Missense_Mutation_p.S5069F|UBR4_ENST00000429347.2_Missense_Mutation_p.S616F|UBR4_ENST00000375254.3_Missense_Mutation_p.S5093F|UBR4_ENST00000375217.2_Missense_Mutation_p.S5086F			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	5093					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AAAGAGAAGGGAAGAACGGTA	0.473000													13	29					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226608	23226608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23226608G>A	ENST00000300061.2	+	13	1911	c.1768G>A	c.(1768-1770)Ggc>Agc	p.G590S		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	590					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TAGCCCACAGGGCCAGGACAA	0.597000													35	105					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62020413	62020413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62020413G>A	ENST00000578147.1	-	23	4137	c.4061C>T	c.(4060-4062)gCc>gTc	p.A1354V	SCN4A_ENST00000435607.1_Missense_Mutation_p.A1354V			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1354					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GATGTCGAAGGCCTGCTTCGT	0.557000													45	78					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94083510	94083510	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94083510T>G	ENST00000553484.1	+	29	4304	c.4150T>G	c.(4150-4152)Tta>Gta	p.L1384V	UNC79_ENST00000555664.1_Missense_Mutation_p.L1362V|UNC79_ENST00000393151.2_Missense_Mutation_p.L1362V|UNC79_ENST00000256339.4_Missense_Mutation_p.L1185V			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1362						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCTTCTCCCCTTAGTGGTTCA	0.433000													26	122					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28755048	28755048	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:28755048C>T	ENST00000422425.2	+	9	586	c.542C>T	c.(541-543)cCc>cTc	p.P181L	PLB1_ENST00000327757.5_Missense_Mutation_p.P181L	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	181	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TACCTGTGCCCCTCTGCTCAA	0.478000													33	159					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133805038	133805038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133805038C>T	ENST00000372338.4	-	2	710	c.468G>A	c.(466-468)acG>acA	p.T156T	FIBCD1_ENST00000253018.4_5'UTR|FIBCD1_ENST00000448616.1_Silent_p.T156T|FIBCD1_ENST00000372337.2_5'UTR	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	156					signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CCATGCACTCCGTCTGCAGCT	0.721000													8	21					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48164723	48164723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48164723C>T	ENST00000311303.3	-	8	1557	c.1212G>A	c.(1210-1212)gcG>gcA	p.A404A	ABCC12_ENST00000416054.1_Silent_p.A404A|ABCC12_ENST00000448542.1_Silent_p.A404A	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	404						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GAGAGACATTCGCTTCAGCCA	0.423000													20	40					0	0	1	0	0
MDK	4192	broad.mit.edu	37	11	46403895	46403895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:46403895G>A	ENST00000405308.2	+	3	557	c.128G>A	c.(127-129)gGg>gAg	p.G43E	MDK_ENST00000407067.1_Missense_Mutation_p.G43E|MDK_ENST00000395565.1_Missense_Mutation_p.G43E|MDK_ENST00000395566.4_Missense_Mutation_p.G43E|MDK_ENST00000359803.3_Missense_Mutation_p.G43E|MDK_ENST00000533283.1_3'UTR|MDK_ENST00000395569.4_Intron	NM_001270550.1	NP_001257479.1	P21741	MK_HUMAN	midkine (neurite growth-promoting factor 2)	43					adrenal gland development|cell differentiation|nervous system development|positive regulation of cell division|response to wounding|signal transduction	extracellular region	growth factor activity|heparin binding			lung(1)	1				GBM - Glioblastoma multiforme(35;0.0252)|Lung(87;0.14)		TGGGCCTGGGGGCCCTGCACC	0.692000													5	13					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189060833	189060833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189060833C>T	ENST00000332517.3	+	1	261	c.121C>T	c.(121-123)Ctc>Ttc	p.L41F		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	41					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GGTGTGTCTCCTCAGGAGCTG	0.547000													87	206					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86959980	86959980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86959980G>A	ENST00000234701.3	+	12	2142	c.1791G>A	c.(1789-1791)acG>acA	p.T597T	CLCA1_ENST00000394711.1_Silent_p.T597T			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	597					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CTTCCAAAACGAACAAGGACA	0.517000													12	43					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51729087	51729087	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51729087C>T	ENST00000436584.2	+	2	121	c.66C>T	c.(64-66)atC>atT	p.I22I	CD33_ENST00000262262.4_Silent_p.I149I|CD33_ENST00000421133.2_Silent_p.I22I|CD33_ENST00000391796.3_Silent_p.I149I			P20138	CD33_HUMAN	CD33 molecule	149	Ig-like V-type.		W -> R (in dbSNP:rs35814802).		cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AAATCCTCATCCCTGGCACTC	0.572000													47	96					0	0	1	0	0
SH3BGRL3	83442	broad.mit.edu	37	1	26607282	26607282	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26607282C>T	ENST00000270792.5	+	2	1055	c.75C>T	c.(73-75)acC>acT	p.T25T	SH3BGRL3_ENST00000319041.6_Silent_p.T25T	NM_031286.3	NP_112576.1	Q9H299	SH3L3_HUMAN	SH3 domain binding glutamic acid-rich protein like 3	25	Glutaredoxin.				cell redox homeostasis	cytoplasm|nucleus	electron carrier activity|protein disulfide oxidoreductase activity						all_cancers(24;1.16e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.22e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00751)|READ - Rectum adenocarcinoma(331;0.0649)		GCGAGGTGACCCGAATCCTGG	0.587000													14	82					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858356	9858356	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9858356C>T	ENST00000396573.2	-	14	3354	c.3045G>A	c.(3043-3045)aaG>aaA	p.K1015K	GRIN2A_ENST00000404927.2_Silent_p.K1015K|GRIN2A_ENST00000562109.1_Silent_p.K1015K|GRIN2A_ENST00000330684.3_Silent_p.K1015K|GRIN2A_ENST00000396575.2_Silent_p.K1015K|GRIN2A_ENST00000535259.1_Silent_p.K858K	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1015					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCACGGATTTCTTCCACAGCT	0.532000													36	74					0	0	1	0	0
GDF9	2661	broad.mit.edu	37	5	132197785	132197785	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132197785A>C	ENST00000378673.2	-	3	1727	c.861T>G	c.(859-861)ccT>ccG	p.P287P	GDF9_ENST00000296875.2_Silent_p.P287P			O60383	GDF9_HUMAN	growth differentiation factor 9	287					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACCCTGGGAAGGCCTCCTTT	0.512000													21	49					0	0	1	0	0
SLC2A4	6517	broad.mit.edu	37	17	7186949	7186949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7186949C>T	ENST00000317370.8	+	3	576	c.308C>T	c.(307-309)tCt>tTt	p.S103F	RP1-4G17.2_ENST00000576271.1_RNA|SLC2A4_ENST00000571308.1_Missense_Mutation_p.S103F|SLC2A4_ENST00000424875.2_Missense_Mutation_p.S93F	NM_001042.2	NP_001033.1	P14672	GTR4_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 4	103					carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding			breast(1)|endometrium(3)|large_intestine(7)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17						GGTATCATCTCTCAGTGGCTT	0.617000													26	45					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129039953	129039953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:129039953G>A	ENST00000274487.4	+	21	3308	c.3163G>A	c.(3163-3165)Ggc>Agc	p.G1055S	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1055	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GTGTGGCAAAGGCATACGTCA	0.423000													53	128					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997547	46997547	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46997547C>T	ENST00000599531.1	-	1	2208	c.1176G>A	c.(1174-1176)gaG>gaA	p.E392E	PNMAL2_ENST00000594749.1_Intron|PNMAL2_ENST00000377655.2_Intron	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	392										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CGCGGCCCGCCTCTTCCACCT	0.672000													6	30					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43212399	43212399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43212399C>T	ENST00000255226.6	+	5	1422	c.606C>T	c.(604-606)taC>taT	p.Y202Y	SLC14A2_ENST00000586448.1_Silent_p.Y202Y	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	202						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AGTTAGACTACTACTGGTGGC	0.552000													34	151					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626688	140626688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140626688C>T	ENST00000231173.3	+	1	1542	c.1542C>T	c.(1540-1542)ttC>ttT	p.F514F		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		514	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCACCTGTTCGCTCTCCAGT	0.692000													41	198					0	0	1	0	0
CALHM1	255022	broad.mit.edu	37	10	105215200	105215200	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105215200C>T	ENST00000329905.5	-	2	996	c.860G>A	c.(859-861)aGg>aAg	p.R287K	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	287						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						CAGCTTCTCCCTTTCCTCCTC	0.647000													15	27					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017381	93017381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:93017381C>T	ENST00000523629.1	-	6	1157	c.703G>A	c.(703-705)Gat>Aat	p.D235N	RUNX1T1_ENST00000521553.1_Missense_Mutation_p.D198N|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.D246N|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.D198N|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.D208N|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.D198N|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.D235N|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.D198N|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.D208N	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	235					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCGTTCACATCGAGAAGCAGC	0.552000													24	119					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125989806	125989806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125989806G>A	ENST00000319286.5	+	3	1450	c.1296G>A	c.(1294-1296)agG>agA	p.R432R		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	432					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R432R(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTCACCAAAGGACACATACAG	0.438000										HNSCC(60;0.17)			39	76					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28649015	28649015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28649015C>T	ENST00000280904.6	-	15	2796	c.2353G>A	c.(2353-2355)Gaa>Aaa	p.E785K	DSC2_ENST00000251081.6_Missense_Mutation_p.E785K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	785					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTCACCATTTCGATGGTCTCC	0.582000													14	60					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18368336	18368336	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18368336G>A	ENST00000392413.3	-	4	3973	c.3758C>T	c.(3757-3759)cCt>cTt	p.P1253L	KIAA1683_ENST00000600328.2_Missense_Mutation_p.P1066L|KIAA1683_ENST00000600359.2_Missense_Mutation_p.P1020L	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	0						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						ACAGGTGCGAGGGCTGGAGCC	0.687000													5	14					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105421084	105421084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105421084C>T	ENST00000333244.5	-	7	823	c.704G>A	c.(703-705)gGa>gAa	p.G235E		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	235						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCCCCATCTCCTTCCAGAGT	0.537000													14	24					0	0	1	0	0
GOLGA8IP	283796	broad.mit.edu	37	15	23262319	23262319	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23262319G>A	ENST00000450802.3	+	13	1274	c.1176G>A	c.(1174-1176)aaG>aaA	p.K392K																								AGCAAGTAAAGGAGCTACAGG	0.577000													10	36					0	0	1	0	0
AADAC	13	broad.mit.edu	37	3	151545614	151545614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151545614C>T	ENST00000232892.6	+	5	980	c.854C>T	c.(853-855)tCc>tTc	p.S285F	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	285					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AATTGGAGTTCCCTGCTCCCT	0.383000													40	98					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47602361	47602361	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47602361G>A	ENST00000273857.4	-	21	2815	c.2816C>T	c.(2815-2817)cCa>cTa	p.P939L	CORIN_ENST00000502252.1_Missense_Mutation_p.P872L|CORIN_ENST00000505909.1_Missense_Mutation_p.P902L|CORIN_ENST00000508498.1_Missense_Mutation_p.P800L	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	939	Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						CAGCTTAAATGGCACTGaatt	0.363000													17	37					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363473	22363473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22363473G>A	ENST00000397121.2	-	3	1363	c.1046C>T	c.(1045-1047)tCc>tTc	p.S349F		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAGGATTGAGGATCGATTAAA	0.403000													31	120					0	0	1	0	0
OTC	5009	broad.mit.edu	37	X	38262948	38262948	+	Missense_Mutation	SNP	G	G	A	rs72558413		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:38262948G>A	ENST00000039007.4	+	6	770	c.618G>A	c.(616-618)atG>atA	p.M206I	TM4SF2_ENST00000465127.1_Intron	NM_000531.5	NP_000522.3	P00480	OTC_HUMAN	ornithine carbamoyltransferase	206			M -> I (in OTCD).|M -> R (in OTCD; neonatal).		arginine biosynthetic process|urea cycle	mitochondrial matrix|ornithine carbamoyltransferase complex	ornithine carbamoyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22					L-Citrulline(DB00155)|L-Ornithine(DB00129)	CCATCATGATGAGCGCAGCGA	0.483000													29	21					0	0	1	0	0
AGT	183	broad.mit.edu	37	1	230841825	230841825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230841825C>T	ENST00000366667.4	-	3	1192	c.978G>A	c.(976-978)caG>caA	p.Q326Q		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	326					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	AGAAGTTGTCCTGGATGTCAC	0.592000													26	101					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110809020	110809020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:110809020C>T	ENST00000282356.4	+	8	1035	c.637C>T	c.(637-639)Ctt>Ttt	p.L213F	CAMK4_ENST00000512453.1_Missense_Mutation_p.L213F	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	213	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		ACCTGAAATTCTTAGAGGTTG	0.318000													34	131					0	0	1	0	0
FGF7	2252	broad.mit.edu	37	15	49716709	49716709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:49716709G>A	ENST00000267843.4	+	2	826	c.215G>A	c.(214-216)cGa>cAa	p.R72Q	FGF7_ENST00000560270.1_Missense_Mutation_p.R72Q|FAM227B_ENST00000561064.1_Intron|FAM227B_ENST00000299338.6_Intron	NM_002009.3	NP_002000.1	P21781	FGF7_HUMAN	fibroblast growth factor 7	72					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	CTCTTCTGTCGAACACAGTGG	0.408000													30	68					0	0	1	0	0
TNFRSF11A	8792	broad.mit.edu	37	18	60028961	60028961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:60028961C>T	ENST00000586569.1	+	7	703	c.665C>T	c.(664-666)tCt>tTt	p.S222F	TNFRSF11A_ENST00000269485.7_Intron	NM_003839.2	NP_003830.1	Q9Y6Q6	TNR11_HUMAN	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	222					adaptive immune response|cell-cell signaling|circadian temperature homeostasis|monocyte chemotaxis|osteoclast differentiation|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|response to interleukin-1|response to lipopolysaccharide	external side of plasma membrane|integral to membrane	metal ion binding|tumor necrosis factor receptor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(13)|skin(3)|upper_aerodigestive_tract(1)	29		Colorectal(73;0.188)				CTCTTCGCGTCTGTGGCCCTG	0.408000													93	232					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189856244	189856244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189856244C>T	ENST00000304636.3	+	12	1054	c.884C>T	c.(883-885)gCt>gTt	p.A295V	COL3A1_ENST00000317840.5_Missense_Mutation_p.A295V	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	295	Triple-helical region.			NGA -> DGS (in Ref. 9; AA sequence).	axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GAAAATGGAGCTCCTGGACCC	0.318000													21	49					0	0	1	0	0
SLC52A2	79581	broad.mit.edu	37	8	145583659	145583659	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145583659C>T	ENST00000532887.1	+	3	1090	c.507C>T	c.(505-507)cgC>cgT	p.R169R	SLC52A2_ENST00000329994.2_Silent_p.R169R|SLC52A2_ENST00000526891.1_3'UTR|SLC52A2_ENST00000402965.1_Silent_p.R169R|SLC52A2_ENST00000527078.1_Silent_p.R169R|SLC52A2_ENST00000540505.1_Silent_p.R81R|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000530047.1_Silent_p.R169R			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	169						integral to plasma membrane	receptor activity|riboflavin transporter activity										GTGTGGGCCGCCTCGAGTGCC	0.667000													27	110					0	0	1	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67220438	67220438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:67220438G>A	ENST00000282670.2	+	2	225	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	TCTEX1D1_ENST00000491611.1_3'UTR	NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	33								p.E33K(1)		large_intestine(2)|lung(10)|skin(1)	13						TTGGCGAAAGGAAATTCATGG	0.338000													11	40					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767876	57767876	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57767876G>A	ENST00000371030.2	+	1	1802	c.1802G>A	c.(1801-1803)aGa>aAa	p.R601K		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	601						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGCAAGGGCAGAGCGGGCGGC	0.622000													18	67					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2026901	2026901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2026901G>A	ENST00000262113.4	+	12	1490	c.1349G>A	c.(1348-1350)gGa>gAa	p.G450E	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	450	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTTTTTGAAGGAAGGTCTTAC	0.507000													99	200					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3686423	3686423	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3686423C>T	ENST00000344754.4	-	3	673	c.674G>A	c.(673-675)aGg>aAg	p.R225K	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.R225K	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	225	Ig-like C2-type 1.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCTCTGAGCCCTGTGATTGGC	0.632000													29	71					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82835853	82835853	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82835853C>T	ENST00000265077.3	+	8	7596	c.7031C>T	c.(7030-7032)cCc>cTc	p.P2344L	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.P1357L|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2344	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GCAGAAGGACCCACGGTGGCA	0.468000													21	82					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191299	6191299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6191299G>A	ENST00000530810.1	-	1	339	c.258C>T	c.(256-258)atC>atT	p.I86I	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAGCCAAAAGATGGCTAGGG	0.493000													47	125					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179418650	179418650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179418650C>T	ENST00000589042.1	-	333	89412	c.89188G>A	c.(89188-89190)Gat>Aat	p.D29730N	TTN_ENST00000342992.6_Missense_Mutation_p.D27162N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D20665N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D20857N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D20790N|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D28089N|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28089	Fibronectin type-III 116.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAATAGGATCAGCAGCTTTG	0.393000													11	35					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55281307	55281307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55281307C>T	ENST00000336077.6	+	1	45	c.5C>T	c.(4-6)tCg>tTg	p.S2L	KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000402254.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL1_ENST00000291633.7_Missense_Mutation_p.S2L|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	2					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		AGCACCATGTCGCTCTTGGTC	0.587000											OREG0003674	type=REGULATORY REGION|Gene=KIR2DL1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	24	89					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141543929	141543929	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141543929G>T	ENST00000442267.2	-	21	3295	c.3221C>A	c.(3220-3222)cCt>cAt	p.P1074H		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1074						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CTCCTTTGCAGGCTGGGCCAC	0.657000													7	24					1.06961e-07	1.07285e-07	1	1	0
COL6A6	131873	broad.mit.edu	37	3	130292924	130292924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130292924C>T	ENST00000358511.6	+	7	3133	c.3102C>T	c.(3100-3102)ctC>ctT	p.L1034L	COL6A6_ENST00000453409.2_Silent_p.L1034L	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	1034	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ATGTCAGCCTCAACAGAGTGC	0.418000													12	33					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41442369	41442369	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41442369G>A	ENST00000599198.1	+	0	461					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						AGGGACTTCGGGATGGGAAAG	0.562000													13	27					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126410110	126410110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:126410110C>T	ENST00000339582.2	-	7	1974	c.1166G>A	c.(1165-1167)cGa>cAa	p.R389Q	GRM8_ENST00000405249.1_Missense_Mutation_p.R389Q|GRM8_ENST00000444921.2_Missense_Mutation_p.R389Q|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Missense_Mutation_p.R389Q			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	389					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCGAGCAATTCGCTCCAGCCC	0.383000										HNSCC(24;0.065)			7	17					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42375973	42375973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42375973C>T	ENST00000290472.3	-	7	570	c.476G>A	c.(475-477)cGa>cAa	p.R159Q		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	159					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TGACAGCTCTCGGGCCTGGGG	0.602000													42	87					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11117598	11117598	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:11117598G>A	ENST00000304623.8	-	13	2430	c.2241C>T	c.(2239-2241)atC>atT	p.I747I	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Silent_p.I314I|CTNND2_ENST00000511377.1_Silent_p.I656I|CTNND2_ENST00000503622.1_Silent_p.I410I|CTNND2_ENST00000359640.2_Silent_p.I747I	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	747					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GCGCAGACTGGATCACGTACA	0.507000													56	122					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54804695	54804695	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54804695C>T	ENST00000306858.7	+	5	1042	c.926C>T	c.(925-927)tCg>tTg	p.S309L		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	309										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TACCAGCATTCGGTGTCTTCA	0.433000													26	95					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126241007	126241007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126241007G>A	ENST00000394329.3	+	1	3454	c.3441G>A	c.(3439-3441)gaG>gaA	p.E1147E		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1147	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAGATTTTGAGTTGCATGCCA	0.448000													64	150					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907225	164907225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164907225C>T	ENST00000475390.1	-	2	1837	c.1394G>A	c.(1393-1395)gGc>gAc	p.G465D	SLITRK3_ENST00000241274.3_Missense_Mutation_p.G465D			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	465						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TATATCGTTGCCATTAAGGAA	0.463000										HNSCC(40;0.11)			14	44					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234878916	234878916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234878916C>T	ENST00000324695.4	+	17	2241	c.2201C>T	c.(2200-2202)cCc>cTc	p.P734L	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	734						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TTCACCTCCCCCTTCGTGGTC	0.542000													90	255					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36081686	36081686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:36081686G>A	ENST00000360731.3	+	6	1803	c.1803G>A	c.(1801-1803)agG>agA	p.R601R	CLIC6_ENST00000349499.2_Silent_p.R583R			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	601	GST C-terminal.					chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						AGGCCCTGAGGAAGCTGGATA	0.453000													28	75					0	0	1	0	0
NADK	65220	broad.mit.edu	37	1	1686834	1686834	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1686834G>A	ENST00000344463.4	-	9	1323	c.1102C>T	c.(1102-1104)Caa>Taa	p.Q368*	NADK_ENST00000378625.1_Nonsense_Mutation_p.Q368*|NADK_ENST00000341991.3_Nonsense_Mutation_p.Q223*|NADK_ENST00000341426.5_Nonsense_Mutation_p.Q223*|NADK_ENST00000342348.5_Nonsense_Mutation_p.Q191*			O95544	NADK_HUMAN	NAD kinase	223					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding			NS(1)|autonomic_ganglia(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|stomach(1)|urinary_tract(1)	17	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		TGAGTAACTTGGGACTGAAAG	0.577000													19	260					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177694313	177694313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:177694313G>A	ENST00000390654.3	-	8	874	c.517C>T	c.(517-519)Ccc>Tcc	p.P173S	COL23A1_ENST00000407622.1_Missense_Mutation_p.P137S	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	173	Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CTTACCCGGGGGCCAAAGTCT	0.557000													7	40					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878387	150878387	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150878387C>T	ENST00000422024.1	-	3	1003	c.878G>A	c.(877-879)gGc>gAc	p.G293D	ASB10_ENST00000275838.1_Missense_Mutation_p.G248D|ASB10_ENST00000434669.1_Missense_Mutation_p.G293D|ASB10_ENST00000420175.2_Missense_Mutation_p.G248D|ASB10_ENST00000377867.3_Missense_Mutation_p.G233D	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	248					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGGTCCAGCCTTCGGCATT	0.657000													10	28					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180381713	180381713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:180381713C>T	ENST00000273654.4	-	8	1023	c.404G>A	c.(403-405)cGa>cAa	p.R135Q	CCDC39_ENST00000442201.2_Missense_Mutation_p.R51Q			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	51					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AGAATTAATTCGCTCTTCATA	0.328000													30	83					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428313	128428313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:128428313G>A	ENST00000465342.2	+	2	1359	c.202G>A	c.(202-204)Gag>Aag	p.E68K	POU5F1B_ENST00000391675.1_Missense_Mutation_p.E68K|CASC8_ENST00000502082.1_RNA|CASC8_ENST00000523825.1_RNA|CASC8_ENST00000501396.1_RNA			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	68						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						CCCGCCGTATGAGTTATGTGG	0.657000													15	24					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52571156	52571156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52571156G>A	ENST00000443683.2	-	4	495	c.8C>T	c.(7-9)tCa>tTa	p.S3L	MYO5C_ENST00000541028.1_5'UTR|MYO5C_ENST00000261839.7_Silent_p.I121I			Q9NQX4	MYO5C_HUMAN	myosin VC	0	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AGGCGTGGATGATGGCATCTC	0.493000													40	79					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651838	84651838	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84651838G>T	ENST00000286744.5	+	21	3682	c.3458G>T	c.(3457-3459)gGg>gTg	p.G1153V	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G1153V	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1153						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CAGCTCAGAGGGGAAACAGGG	0.547000													14	48					4.93089e-13	4.95554e-13	1	1	0
GPR98	84059	broad.mit.edu	37	5	89948163	89948163	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89948163G>A	ENST00000405460.2	+	19	3513	c.3416_splice	c.e19-1	p.W1139_splice		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1139					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATTTTGTAGGATTTTGAGGC	0.343000													39	111					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69536064	69536064	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69536064C>T	ENST00000338206.5	-	1	282	c.273G>A	c.(271-273)ctG>ctA	p.L91L		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	91					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CGAGAATTTTCAGAAGAGAAT	0.294000													43	105					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67136784	67136784	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67136784G>A	ENST00000284425.2	-	2	235	c.61C>T	c.(61-63)Ctt>Ttt	p.L21F	ABCA6_ENST00000590645.1_Missense_Mutation_p.L21F	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	21					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CATTTCTTAAGAAAATTCTTG	0.363000													23	90					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884747	39884747	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39884747C>T	ENST00000341184.6	+	2	1610	c.1395C>T	c.(1393-1395)ttC>ttT	p.F465F		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	465					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GGGGCTGGTTCGACGGCACGC	0.637000													7	25					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65181297	65181297	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:65181297A>C	ENST00000310045.7	-	2	2052	c.579T>G	c.(577-579)ttT>ttG	p.F193L		NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	183						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				AGTTATATAAAAAGTCAAAGG	0.403000													28	51					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43922587	43922587	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43922587G>A	ENST00000329196.5	+	1	332	c.315G>A	c.(313-315)acG>acA	p.T105T	MAPT-AS1_ENST00000579244.1_RNA|MAPT-AS1_ENST00000579599.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	105						integral to membrane	aspartic-type endopeptidase activity										GCTTCCACACGAAAGGCTGGC	0.667000													8	30					0	0	1	0	0
P4HA1	5033	broad.mit.edu	37	10	74831805	74831805	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74831805G>A	ENST00000412021.2	-	5	640	c.307C>T	c.(307-309)Ctt>Ttt	p.L103F	P4HA1_ENST00000440381.1_Missense_Mutation_p.L103F|P4HA1_ENST00000263556.3_Missense_Mutation_p.L103F|P4HA1_ENST00000307116.2_Missense_Mutation_p.L103F|RP11-344N10.2_ENST00000431293.2_RNA|P4HA1_ENST00000394890.2_Missense_Mutation_p.L103F|P4HA1_ENST00000373008.2_Missense_Mutation_p.L103F	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	103						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ATATCCTTAAGGACCAGATTC	0.363000													63	206					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685641	100685641	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100685641C>T	ENST00000306151.4	+	3	11008	c.10944C>T	c.(10942-10944)acC>acT	p.T3648T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3648	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CATCGGTGACCATTTCTGAGG	0.488000													75	187					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6435711	6435711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6435711G>A	ENST00000449001.2	+	13	2040	c.1546G>A	c.(1546-1548)Gag>Aag	p.E516K	PLEKHG6_ENST00000304581.8_Missense_Mutation_p.E78K|PLEKHG6_ENST00000011684.7_Missense_Mutation_p.E548K|PLEKHG6_ENST00000396988.3_Missense_Mutation_p.E548K	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	548					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						GCCTTCCCTGGAGGGCTCTCA	0.607000													8	30					0	0	1	0	0
KDM4D	55693	broad.mit.edu	37	11	94731667	94731667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94731667C>T	ENST00000335080.5	+	3	1963	c.1131C>T	c.(1129-1131)ctC>ctT	p.L377L	KDM4D_ENST00000536741.1_Silent_p.L377L	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	377					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TGAGACAACTCCCTTCCCACT	0.632000													6	44					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428286	128428286	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:128428286G>A	ENST00000465342.2	+	2	1332	c.175G>A	c.(175-177)Ggg>Agg	p.G59R	POU5F1B_ENST00000391675.1_Missense_Mutation_p.G59R|CASC8_ENST00000502082.1_RNA|CASC8_ENST00000523825.1_RNA|CASC8_ENST00000501396.1_RNA			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	59						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						TGAGGTGTGGGGGATTCCCCC	0.667000													6	26					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57032176	57032176	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57032176G>A	ENST00000262030.3	-	10	1571	c.1521C>T	c.(1519-1521)ttC>ttT	p.F507F	ATP5B_ENST00000552919.1_Silent_p.F496F	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	507					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCACCATATAGAAGGCCTGTT	0.458000													55	109					0	0	1	0	0
ATP1B4	23439	broad.mit.edu	37	X	119510247	119510247	+	Missense_Mutation	SNP	C	C	T	rs149447498		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:119510247C>T	ENST00000218008.3	+	6	829	c.772C>T	c.(772-774)Cgt>Tgt	p.R258C	ATP1B4_ENST00000539306.1_Missense_Mutation_p.R215C|ATP1B4_ENST00000361319.3_Missense_Mutation_p.R254C	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	258					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity	p.R254C(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						TGTAGGCTTTCGTCCTGAGCT	0.363000													28	11					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51758498	51758498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51758498G>A	ENST00000251076.5	-	30	7687	c.7400C>T	c.(7399-7401)cCt>cTt	p.P2467L	RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000543779.2_Missense_Mutation_p.P2468L|DMXL2_ENST00000449909.3_Missense_Mutation_p.P1831L	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2467						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		ATCAGACAAAGGAAGAAATGG	0.244000													28	84					0	0	1	0	0
RAD17	5884	broad.mit.edu	37	5	68677778	68677778	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:68677778G>A	ENST00000509734.1	+	6	1113	c.435G>A	c.(433-435)acG>acA	p.T145T	RAD17_ENST00000345306.6_Silent_p.T134T|RAD17_ENST00000305138.4_Silent_p.T134T|RAD17_ENST00000282891.6_Silent_p.T48T|RAD17_ENST00000354868.5_Silent_p.T134T|RAD17_ENST00000504177.1_Intron|RAD17_ENST00000354312.3_Silent_p.T134T|RAD17_ENST00000380774.3_Silent_p.T145T|RAD17_ENST00000361732.2_Silent_p.T134T|RAD17_ENST00000358030.2_5'UTR|RAD17_ENST00000521422.1_5'UTR			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	145					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		GAAAGACAACGACCTTAAAAA	0.333000								Other conserved DNA damage response genes					23	69					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603722	5603722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5603722C>T	ENST00000423158.3	+	2	593	c.381C>T	c.(379-381)ccC>ccT	p.P127P	NTF3_ENST00000331010.6_Silent_p.P114P|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	114					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						CCTTGGAGCCCCCGCCCTTGT	0.612000													21	71					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42490090	42490090	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42490090C>T	ENST00000545399.1	-	6	724	c.571G>A	c.(571-573)Ggg>Agg	p.G191R	ATP1A3_ENST00000602133.1_Missense_Mutation_p.G148R|ATP1A3_ENST00000543770.1_Missense_Mutation_p.G189R|ATP1A3_ENST00000302102.5_Missense_Mutation_p.G178R	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	178					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						ACCAGGTCCCCGACCACCACC	0.632000													41	130					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44371764	44371764	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44371764C>T	ENST00000371477.3	+	6	1057	c.758_splice	c.e6+1	p.S253_splice		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	253					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding	p.S253F(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAGCTAAGATCGTAAGTTGCC	0.398000													17	66					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328133	126328133	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126328133G>A	ENST00000394329.3	+	3	5419	c.5406G>A	c.(5404-5406)ttG>ttA	p.L1802L	FAT4_ENST00000335110.5_Silent_p.L100L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1802	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCAGGCGGTTGGACAGGGAAC	0.468000													56	131					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51378008	51378008	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51378008G>A	ENST00000325321.3	+	2	303	c.78G>A	c.(76-78)gtG>gtA	p.V26V	KLK2_ENST00000358049.4_Silent_p.V26V|KLK2_ENST00000391810.2_Intron|KLK2_ENST00000597509.1_3'UTR|AC037199.1_ENST00000594218.1_Intron			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	26	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		CTCGGATTGTGGGAGGCTGGG	0.622000			T	ETV4	prostate								13	55					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42941120	42941120	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42941120G>A	ENST00000426333.2	-	15	1613	c.1316C>T	c.(1315-1317)cCt>cTt	p.P439L	EFTUD2_ENST00000402521.3_Missense_Mutation_p.P404L|EFTUD2_ENST00000592576.1_Missense_Mutation_p.P429L|EFTUD2_ENST00000591382.1_Missense_Mutation_p.P439L	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	439						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CTTTGGAGAAGGGATATGCTG	0.547000													22	29					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117993041	117993041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117993041C>T	ENST00000425217.1	-	9	1418	c.1364G>A	c.(1363-1365)cGg>cAg	p.R455Q	KSR2_ENST00000302438.5_Missense_Mutation_p.R181Q|KSR2_ENST00000339824.5_Missense_Mutation_p.R484Q|KSR2_ENST00000545002.1_5'UTR	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	484					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGTGGCTTCCGTAGAGGGTT	0.502000													14	22					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21214532	21214532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21214532G>A	ENST00000574002.1	-	11	1495	c.1013C>T	c.(1012-1014)tCa>tTa	p.S338L	ZP2_ENST00000219593.4_Missense_Mutation_p.S338L|AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Missense_Mutation_p.S338L			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	338					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		CAGCTTGAGTGAAGCTAAGTA	0.463000													21	81					0	0	1	0	0
C1orf51	148523	broad.mit.edu	37	1	150255959	150255959	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150255959G>A	ENST00000290363.5	+	1	731	c.282G>A	c.(280-282)gcG>gcA	p.A94A	C1orf51_ENST00000469255.1_3'UTR|C1orf51_ENST00000369094.1_Silent_p.A6A|C1orf51_ENST00000369095.1_Silent_p.A94A	NM_144697.2	NP_653298.1	Q8N365	CA051_HUMAN	chromosome 1 open reading frame 51	94										endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(2)	10	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GATCTGGGGCGAAAAGATCAA	0.527000													48	118					0	0	1	0	0
LRRC40	55631	broad.mit.edu	37	1	70644631	70644631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70644631G>A	ENST00000370952.3	-	6	786	c.707C>T	c.(706-708)cCt>cTt	p.P236L		NM_017768.4	NP_060238.3	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	236										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(2)	27						CAATTCAGGAGGTATAGTTTC	0.313000													8	43					0	0	1	0	0
ZNF622	90441	broad.mit.edu	37	5	16463747	16463747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:16463747G>A	ENST00000308683.2	-	2	856	c.730C>T	c.(730-732)Cca>Tca	p.P244S		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	244						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						CCAAGGGGTGGGCCTTCCTCA	0.488000													69	229					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17922823	17922823	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17922823C>T	ENST00000318683.6	+	3	1158	c.1011C>T	c.(1009-1011)taC>taT	p.Y337Y	B3GNT3_ENST00000595387.1_Silent_p.Y337Y	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	337					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						CCTGCTTCTACCGAGACCTGC	0.612000													69	170					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116037711	116037711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116037711G>A	ENST00000603594.1	+	7	926	c.605G>A	c.(604-606)gGg>gAg	p.G202E	VWA2_ENST00000392982.3_Missense_Mutation_p.G202E	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	202	VWFA 1.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GAGCCTAGAGGGCAGCACGTG	0.632000													11	20					0	0	1	0	0
CCNF	899	broad.mit.edu	37	16	2498891	2498891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2498891C>T	ENST00000397066.4	+	11	1218	c.1130C>T	c.(1129-1131)gCc>gTc	p.A377V		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	377	Cyclin N-terminal.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				ATCCGGGAGGCCGTATGGCTC	0.587000													34	110					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42695407	42695407	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42695407G>A	ENST00000358131.5	+	7	1548	c.1340G>A	c.(1339-1341)gGa>gAa	p.G447E	TOX2_ENST00000372999.1_Missense_Mutation_p.G423E|TOX2_ENST00000435864.2_Missense_Mutation_p.G343E|TOX2_ENST00000423191.1_Missense_Mutation_p.G423E|TOX2_ENST00000341197.3_Missense_Mutation_p.G465E	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	447	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGCAGCTCGGGATCCTGCTCA	0.632000													43	107					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084728	53084728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:53084728C>T	ENST00000276480.7	-	10	1376	c.693G>A	c.(691-693)ttG>ttA	p.L231L		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	231						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CAGGAACTTCCAATAGGTCTT	0.418000													18	69					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61414214	61414214	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61414214G>A	ENST00000395348.3	-	5	1206	c.570C>T	c.(568-570)ccC>ccT	p.P190P	SLC16A9_ENST00000395347.1_Silent_p.P190P	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	190					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						AAGATTGGAGGGGTCTCATCA	0.403000													43	112					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236205533	236205533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236205533G>A	ENST00000264187.6	-	4	894	c.812C>T	c.(811-813)aCc>aTc	p.T271I	NID1_ENST00000366595.3_Missense_Mutation_p.T271I	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	271					cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CACGCCATTGGTGGTGGCTGG	0.552000													95	216					0	0	1	0	0
ANGPTL7	10218	broad.mit.edu	37	1	11253760	11253760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11253760G>A	ENST00000376819.3	+	3	840	c.601G>A	c.(601-603)Gac>Aac	p.D201N	ANGPTL7_ENST00000476934.1_3'UTR|MTOR_ENST00000361445.4_Intron	NM_021146.2	NP_066969.1	O43827	ANGL7_HUMAN	angiopoietin-like 7	201	Fibrinogen C-terminal.				response to oxidative stress|signal transduction	extracellular region	receptor binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(2)|stomach(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.39e-06)|COAD - Colon adenocarcinoma(227;0.000244)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0487)		CATCCGTGGGGACTTCTGGCT	0.597000													26	58					0	0	1	0	0
TET1	80312	broad.mit.edu	37	10	70446398	70446398	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70446398C>T	ENST00000373644.4	+	11	5547	c.5338C>T	c.(5338-5340)Cga>Tga	p.R1780*		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1780					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						ACCTATTCCCCGAATCAAGCG	0.468000													21	81					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75929446	75929446	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:75929446G>A	ENST00000321027.3	-	3	631	c.498C>T	c.(496-498)tcC>tcT	p.S166S	GCFC2_ENST00000409857.3_Silent_p.S166S|GCFC2_ENST00000470503.1_Silent_p.S166S|GCFC2_ENST00000541687.1_Silent_p.S166S	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	166					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										TACCAGAGATGGAGGAGGTAT	0.453000													57	119					0	0	1	0	0
TRAV41	28640	broad.mit.edu	37	14	22788875	22788875	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22788875C>T	ENST00000390468.1	+	0	88																											GGAGCAGAGTCCTCAGAACCT	0.418000													12	14					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107684286	107684286	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107684286C>T	ENST00000388781.3	-	29	4465	c.4382G>A	c.(4381-4383)aGg>aAg	p.R1461K	LAMB4_ENST00000205386.4_Missense_Mutation_p.R1461K|LAMB4_ENST00000388780.3_Missense_Mutation_p.R1461K	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1461	Domain I.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CAGTTTTTCCCTCAGCTGTAA	0.323000													19	61					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6702545	6702545	+	Missense_Mutation	SNP	C	C	T	rs143642234		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6702545C>T	ENST00000245907.6	-	18	2383	c.2291G>A	c.(2290-2292)cGa>cAa	p.R764Q		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	764					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding	p.R764Q(1)		breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GAACTCACTTCGGGAAACGAT	0.537000													37	104					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768152	77768152	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77768152C>T	ENST00000521891.2	+	10	9443	c.8995C>T	c.(8995-8997)Caa>Taa	p.Q2999*	ZFHX4_ENST00000050961.6_Nonsense_Mutation_p.Q2954*|ZFHX4_ENST00000455469.2_Nonsense_Mutation_p.Q2954*|ZFHX4_ENST00000518282.1_Nonsense_Mutation_p.Q2973*	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2954						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CATGATCAATCAAGGCGGAAC	0.473000										HNSCC(33;0.089)			7	15					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37044568	37044568	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:37044568C>T	ENST00000282516.8	+	35	6727	c.6228C>T	c.(6226-6228)ctC>ctT	p.L2076L	NIPBL_ENST00000448238.2_Silent_p.L2076L	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2076					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TAATGAAGCTCATCATCAAAT	0.318000													7	79					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24373028	24373028	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24373028G>A	ENST00000005284.3	+	4	1994	c.792G>A	c.(790-792)atG>atA	p.M264I		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	264					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		ACATCTCGATGTTCACCCTCT	0.587000													23	113					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13719036	13719036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13719036C>T	ENST00000265104.4	-	72	12558	c.12454G>A	c.(12454-12456)Gat>Aat	p.D4152N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4152	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGTGGAGGATCGTTGGCAAAT	0.453000									Kartagener syndrome				25	77					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7983746	7983746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7983746C>T	ENST00000399413.3	+	2	667	c.427C>T	c.(427-429)Ctc>Ttc	p.L143F	ALOX12B_ENST00000319144.4_Intron																endometrium(2)	2						CCACTTAGGTCTCTGGGTCTC	0.597000											OREG0024153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	17					0	0	1	0	0
C6orf89	221477	broad.mit.edu	37	6	36882161	36882161	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36882161C>T	ENST00000480824.2	+	5	799	c.505C>T	c.(505-507)Ctg>Ttg	p.L169L	C6orf89_ENST00000510325.2_Silent_p.L63L|C6orf89_ENST00000359359.2_Silent_p.L63L|C6orf89_ENST00000373685.1_Silent_p.L169L|C6orf89_ENST00000355190.3_Silent_p.L176L			Q6UWU4	CF089_HUMAN	chromosome 6 open reading frame 89	169						integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	15						GGTGATGCTCCTGGAAGACGC	0.542000													19	60					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103040467	103040467	+	Silent	SNP	G	G	A	rs11465694		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103040467G>A	ENST00000264260.2	+	4	856	c.267G>A	c.(265-267)tcG>tcA	p.S89S	IL18RAP_ENST00000409369.1_Intron	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	89					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						AACAACCTTCGAATGGAGATC	0.458000													22	52					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2604948	2604948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2604948G>A	ENST00000358864.1	+	17	2227	c.2212G>A	c.(2212-2214)Gag>Aag	p.E738K		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	738						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGTCCTCCAAGAGACCATTGA	0.483000													35	99					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283989	152283989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152283989C>T	ENST00000368799.1	-	3	3408	c.3373G>A	c.(3373-3375)Gaa>Aaa	p.E1125K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1125	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCAGACTGTTCATGAGTGCTC	0.607000									Ichthyosis				128	339					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6520098	6520098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6520098G>A	ENST00000377828.1	+	13	2625	c.2457G>A	c.(2455-2457)cgG>cgA	p.R819R	ESPN_ENST00000461727.1_Silent_p.R253R|ESPN_ENST00000475228.1_3'UTR|ESPN_ENST00000416731.1_Silent_p.R253R	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	819	Glu-rich.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		AGCTGCGGCGGGAGAAGGAAC	0.637000													14	29					0	0	1	0	0
HGSNAT	138050	broad.mit.edu	37	8	43013755	43013755	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:43013755C>T	ENST00000458501.2	+	3	356	c.356C>T	c.(355-357)cCa>cTa	p.P119L	HGSNAT_ENST00000379644.4_Missense_Mutation_p.P91L			Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	119					lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(6)	13	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			CCTCAGAGTCCAAAAGCAGGG	0.488000													33	85					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170177374	170177374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170177374G>A	ENST00000263816.3	-	2	385	c.100C>T	c.(100-102)Cgc>Tgc	p.R34C	LRP2_ENST00000443831.1_Missense_Mutation_p.R34C	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	34	LDL-receptor class A 1.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTTCCACAGCGAAAATGCGCA	0.413000													36	56					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20495414	20495414	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20495414G>A	ENST00000555186.1	+	0	617					NR_038836.1																						TGAGGAAAATGAATCCACAGC	0.393000													14	71					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10104455	10104455	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10104455C>T	ENST00000264828.3	-	17	1700	c.1615G>A	c.(1615-1617)Ggc>Agc	p.G539S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	539	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CCTGGGAGGCCCCGAGCTCCA	0.572000													8	125					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76587742	76587742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:76587742G>A	ENST00000307431.8	+	24	4053	c.3668G>A	c.(3667-3669)gGa>gAa	p.G1223E	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.G1175E|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.G1227E|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.G1151E|RP11-58C22.1_ENST00000563764.1_Missense_Mutation_p.G32E	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1224					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GATCATTCTGGAACAATAGAT	0.373000													4	19					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83224840	83224840	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83224840G>A	ENST00000563800.1	-	5	2445	c.720C>T	c.(718-720)ttC>ttT	p.F240F	CPEB1_ENST00000568757.1_Silent_p.F138F|CPEB1_ENST00000568128.1_Silent_p.F213F|CPEB1_ENST00000562019.1_Silent_p.F213F|CPEB1_ENST00000423133.2_Silent_p.F138F|CPEB1_ENST00000398591.2_Silent_p.F138F|CPEB1_ENST00000398592.2_5'UTR|CPEB1_ENST00000450751.2_Silent_p.F138F|CPEB1_ENST00000261723.6_Silent_p.F216F|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000564522.1_Silent_p.F138F			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	213					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			ACAGAGACAGGAAGGGCAGAG	0.493000													6	32					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9510422	9510422	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9510422G>A	ENST00000246070.2	+	6	1290	c.798G>A	c.(796-798)caG>caA	p.Q266Q	LAMP5_ENST00000427562.2_Silent_p.Q222Q	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	266						integral to membrane		p.Q266H(1)									CTGCCAACCAGGTGCAGATCC	0.547000													13	71					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21588586	21588586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21588586C>T	ENST00000392288.2	+	3	290	c.181C>T	c.(181-183)Ctg>Ttg	p.L61L	ZNF493_ENST00000596302.1_Silent_p.L62L|CTD-2561J22.3_ENST00000600810.1_Silent_p.L42L|ZNF493_ENST00000355504.4_Intron|ZNF493_ENST00000594390.1_Silent_p.L61L|ZNF493_ENST00000339914.6_Silent_p.L62L	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						TAAGCCAGATCTGGTCACCTG	0.408000													42	91					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69000001	69000001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:69000001G>A	ENST00000288368.4	+	19	2347	c.2070G>A	c.(2068-2070)caG>caA	p.Q690Q	PREX2_ENST00000529398.1_3'UTR|RP11-403D15.2_ENST00000526901.1_RNA	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	690	PDZ 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TTGGCTTCCAGATCCGGGGAT	0.443000													40	148					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161022284	161022284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161022284C>T	ENST00000368013.3	-	8	1206	c.886G>A	c.(886-888)Ggt>Agt	p.G296S	ARHGAP30_ENST00000368015.1_Missense_Mutation_p.G119S|ARHGAP30_ENST00000368016.3_Missense_Mutation_p.G296S	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	296					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CCAGAGCGACCTAAATTGAAG	0.547000													95	243					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7636110	7636110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7636110C>T	ENST00000359156.4	-	12	3143	c.2941G>A	c.(2941-2943)Gaa>Aaa	p.E981K	CD163_ENST00000432237.2_Missense_Mutation_p.E981K|CD163_ENST00000539632.1_5'UTR|CD163_ENST00000396620.3_Missense_Mutation_p.E1014K|CD163_ENST00000541972.1_Missense_Mutation_p.E969K	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	981	SRCR 9.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AACTCTGCTTCTTTGAATGCT	0.522000													45	91					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86518880	86518880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:86518880G>A	ENST00000297814.2	-	4	696	c.553C>T	c.(553-555)Ctt>Ttt	p.L185F	KIF27_ENST00000413982.1_Missense_Mutation_p.L185F|KIF27_ENST00000334204.2_Missense_Mutation_p.L185F	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	185	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						ATCTCCAAAAGACTCATCACT	0.408000													99	185					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81585035	81585035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81585035C>T	ENST00000394660.2	+	12	1919	c.1559C>T	c.(1558-1560)tCc>tTc	p.S520F	IL16_ENST00000302987.4_Missense_Mutation_p.S520F	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	520					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						ATGTCTGGGTCCCCAGGGGGA	0.612000													9	69					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56520202	56520202	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56520202G>A	ENST00000390649.3	+	3	491	c.491G>A	c.(490-492)aGc>aAc	p.S164N		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	164						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CAAGGACCAAGCAAGGAAAAA	0.468000													4	19					0	0	1	0	0
TNNI3K	51086	broad.mit.edu	37	1	75005954	75005954	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75005954G>A	ENST00000370891.2	+	26	2707	c.2691G>A	c.(2689-2691)gaG>gaA	p.E897E	TNNI3K_ENST00000326637.3_Silent_p.E796E|FPGT-TNNI3K_ENST00000557284.1_Silent_p.E897E|TNNI3K_ENST00000465473.1_3'UTR	NM_001112808.2	NP_001106279.1			TNNI3 interacting kinase											cervix(1)|endometrium(3)|kidney(5)|large_intestine(21)|lung(31)|ovary(4)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	76						TGTCTTTGGAGGAGATGAAAA	0.358000													20	57					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189964865	189964865	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189964865C>T	ENST00000374866.3	-	4	611	c.336_splice	c.e4-1	p.G113_splice		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	113					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCTTTTGTCCCTGTGACATT	0.328000													23	75					0	0	1	0	0
OSER1	51526	broad.mit.edu	37	20	42825913	42825913	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42825913G>A	ENST00000372970.2	-	6	838	c.658C>T	c.(658-660)Ctg>Ttg	p.L220L	OSER1_ENST00000255174.2_Silent_p.L220L					oxidative stress responsive serine-rich 1																		ACACTCTGCAGGCCTGAAAAG	0.522000													11	80					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628377	173628377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173628377G>A	ENST00000333279.2	-	2	241	c.181C>T	c.(181-183)Cct>Tct	p.P61S		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	77										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						TCATGATGAGGATTCTCAGGA	0.473000													24	50					0	0	1	0	0
EIF5AL1	143244	broad.mit.edu	37	10	81272724	81272724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81272724G>A	ENST00000520547.2	+	1	368	c.319G>A	c.(319-321)Gag>Aag	p.E107K		NM_001099692.1	NP_001093162.1	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like 1	107					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity			endometrium(1)	1	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			GGACAGCGGGGAGGTACCAGA	0.532000													9	98					0	0	1	0	0
CD99	4267	broad.mit.edu	37	X	2632473	2632473	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:2632473C>T	ENST00000381192.3	+	2	260	c.78C>T	c.(76-78)ttC>ttT	p.F26F	CD99_ENST00000482405.2_3'UTR|CD99_ENST00000381184.1_Silent_p.F26F|CD99_ENST00000381187.3_Silent_p.F26F	NM_001277710.1|NM_002414.3	NP_001264639.1|NP_002405.1	P14209	CD99_HUMAN	CD99 molecule	26					cell adhesion	cytoplasm|integral to plasma membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	11						ATGGTGGTTTCGATTTATCCG	0.294000													54	227					0	0	1	0	0
NXPE3	91775	broad.mit.edu	37	3	101540472	101540472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:101540472C>T	ENST00000422132.1	+	5	1551	c.1354C>T	c.(1354-1356)Cct>Tct	p.P452S	NXPE3_ENST00000477909.1_Missense_Mutation_p.P452S|NXPE3_ENST00000273347.5_Missense_Mutation_p.P452S|NXPE3_ENST00000491511.1_Missense_Mutation_p.P452S					neurexophilin and PC-esterase domain family, member 3																		CAGCACCTTCCCTTTGGAAGT	0.547000													20	58					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35692526	35692526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:35692526C>T	ENST00000540320.1	+	16	2692	c.2158C>T	c.(2158-2160)Cat>Tat	p.H720Y	NBEA_ENST00000379939.2_Missense_Mutation_p.H720Y|NBEA_ENST00000310336.4_Missense_Mutation_p.H720Y|NBEA_ENST00000400445.3_Missense_Mutation_p.H720Y			Q8NFP9	NBEA_HUMAN	neurobeachin	720						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGAAAATATTCATGATGTGCT	0.323000													6	20					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51792266	51792266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51792266G>A	ENST00000251076.5	-	18	3442	c.3155C>T	c.(3154-3156)cCt>cTt	p.P1052L	DMXL2_ENST00000543779.2_Missense_Mutation_p.P1052L|DMXL2_ENST00000449909.3_Intron	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1052						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		ATTCATCAAAGGCCATCTCTT	0.413000													25	85					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167240194	167240194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167240194C>T	ENST00000308378.3	-	12	1932	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Intron|WDR49_ENST00000476376.1_Missense_Mutation_p.E368K	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	543										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						AAAGAAATTTCCTTTTGAATC	0.318000													49	28					0	0	1	0	0
IFNG	3458	broad.mit.edu	37	12	68552030	68552030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:68552030G>A	ENST00000229135.3	-	2	255	c.124C>T	c.(124-126)Cat>Tat	p.H42Y	IFNG-AS1_ENST00000536914.1_RNA	NM_000619.2	NP_000610.2	P01579	IFNG_HUMAN	interferon, gamma	42					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	ACATCTGAATGACCTGCATTC	0.313000													12	27					0	0	1	0	0
LMAN2L	81562	broad.mit.edu	37	2	97377690	97377690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:97377690G>A	ENST00000264963.4	-	5	602	c.580C>T	c.(580-582)Cct>Tct	p.P194S	LMAN2L_ENST00000426463.2_Missense_Mutation_p.P60S|LMAN2L_ENST00000377079.4_Missense_Mutation_p.P205S|LMAN2L_ENST00000537039.1_Missense_Mutation_p.P56S|LMAN2L_ENST00000534882.1_Missense_Mutation_p.P49S	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	194	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						AGCTCTGTAGGCCGCCCATCC	0.557000													23	49					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76511007	76511007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76511007C>T	ENST00000389840.5	-	26	4074	c.3950G>A	c.(3949-3951)aGg>aAg	p.R1317K	DNAH17_ENST00000585328.1_Missense_Mutation_p.R1318K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTCCAAAGACCTCATGTCCTT	0.507000													41	97					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31124949	31124949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31124949C>T	ENST00000304166.4	+	9	850	c.561C>T	c.(559-561)ttC>ttT	p.F187F	ADCYAP1R1_ENST00000409489.1_Silent_p.F187F|ADCYAP1R1_ENST00000396211.2_Silent_p.F187F|ADCYAP1R1_ENST00000409363.1_Silent_p.F166F	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	187					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						CACGCAACTTCATCCACATGA	0.532000													33	103					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83931724	83931724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83931724G>A	ENST00000345382.2	-	4	2364	c.2279C>T	c.(2278-2280)cCc>cTc	p.P760L	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.P753L	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	760					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						CCTGCGGGAGGGAAAGGTAGC	0.428000													20	33					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52940209	52940209	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52940209C>T	ENST00000267119.5	-	7	1255	c.1186G>A	c.(1186-1188)Gag>Aag	p.E396K		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	396	Coil 2.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CCCTCCAGCTCGTCCAGCTTG	0.632000													19	57					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7705860	7705860	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7705860C>T	ENST00000441779.2	+	6	470	c.433C>T	c.(433-435)Cac>Tac	p.H145Y	STXBP2_ENST00000414284.2_Missense_Mutation_p.H131Y|STXBP2_ENST00000221283.5_Missense_Mutation_p.H134Y|CTD-3214H19.4_ENST00000595866.1_3'UTR	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	134					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						GAAGGAGATTCACCTTGCCTT	0.627000													36	59					0	0	1	0	0
TMEM176A	55365	broad.mit.edu	37	7	150499314	150499314	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150499314C>T	ENST00000484928.1	+	3	767	c.186C>T	c.(184-186)atC>atT	p.I62I	TMEM176A_ENST00000004103.3_Silent_p.I62I|TMEM176A_ENST00000461345.1_Silent_p.I3I			Q96HP8	T176A_HUMAN	transmembrane protein 176A	62						integral to membrane				breast(1)|endometrium(1)|lung(7)|ovary(2)|stomach(1)	12			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGATGCAGATCGTGCTGGGGA	0.562000													17	48					0	0	1	0	0
TRIM8	81603	broad.mit.edu	37	10	104404680	104404680	+	Silent	SNP	C	C	T	rs11550359		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104404680C>T	ENST00000302424.6	+	1	428	c.306C>T	c.(304-306)ccC>ccT	p.P102P		NM_030912.2	NP_112174.2	Q9BZR9	TRIM8_HUMAN	tripartite motif containing 8	102						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCCCGCTGCCCGCGCAGAAGG	0.711000													4	10					0	0	1	0	0
ZNF587	84914	broad.mit.edu	37	19	58367558	58367558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58367558C>T	ENST00000339656.5	+	2	302	c.120C>T	c.(118-120)taC>taT	p.Y40Y	ZNF587_ENST00000423137.1_Silent_p.Y39Y|ZNF587_ENST00000419854.1_5'UTR|ZNF587B_ENST00000316462.4_3'UTR|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597652.1_Intron|CTD-2583A14.10_ENST00000598031.1_Silent_p.Y40Y|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		GGTGCTTGTACCGTGATGTGA	0.498000													16	91					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922012	24922012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922012C>T	ENST00000329468.2	+	1	1472	c.998C>T	c.(997-999)cCa>cTa	p.P333L		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ATGTCGATTCCATTGCTGCTG	0.577000													25	37					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91645125	91645125	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:91645125G>A	ENST00000509176.1	+	7	2281	c.1993G>A	c.(1993-1995)Gag>Aag	p.E665K	CCSER1_ENST00000504150.1_3'UTR|CCSER1_ENST00000432775.2_Missense_Mutation_p.E665K|CCSER1_ENST00000333691.8_Missense_Mutation_p.E665K	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		TCTTACTGAAGAGCCAGTGCC	0.333000													4	6					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48921756	48921756	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48921756G>A	ENST00000310194.1	+	2	950	c.950G>A	c.(949-951)tGg>tAg	p.W317*	OR8S1_ENST00000551654.1_3'UTR	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	317					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						CAGGCCAGATGGAAGAGACCA	0.577000													14	50					0	0	1	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047788	46047788	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46047788C>T	ENST00000397911.3	+	1	749	c.700C>T	c.(700-702)Ctc>Ttc	p.L234F	TSPEAR_ENST00000323084.4_Intron|KRTAP10-9_ENST00000484861.1_Intron	NM_198690.2	NP_941963.2	P60411	KR109_HUMAN	keratin associated protein 10-9	234	25 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9						TGTGTCCCTCCTCTGCCGCCC	0.687000													32	209					0	0	1	0	0
BAHD1	22893	broad.mit.edu	37	15	40754416	40754416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40754416C>T	ENST00000561234.1	+	3	1994	c.1735C>T	c.(1735-1737)Cct>Tct	p.P579S	BAHD1_ENST00000416165.1_Missense_Mutation_p.P580S|BAHD1_ENST00000560846.1_Missense_Mutation_p.P580S			Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	580	Arg-rich.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(3)|lung(10)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	28		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		GCGCCCACGCCCTCGCCGCCG	0.647000													49	109					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072095	17072095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17072095G>A	ENST00000359963.3	-	1	1605	c.1346C>T	c.(1345-1347)cCt>cTt	p.P449L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	449					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CAAAGTTTTAGGAAGATACTT	0.498000													35	116					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2041159	2041159	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2041159G>A	ENST00000250896.3	-	12	1234	c.990C>T	c.(988-990)ccC>ccT	p.P330P	MKNK2_ENST00000541165.1_Silent_p.P199P|MKNK2_ENST00000309340.7_Silent_p.P330P|MKNK2_ENST00000591601.1_Silent_p.P330P|MKNK2_ENST00000591142.1_Silent_p.P74P|MKNK2_ENST00000588014.1_Silent_p.P74P|MKNK2_ENST00000591588.1_Silent_p.P74P	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	330	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCCTTGTCGGGGAACTCGT	0.597000													38	86					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14939133	14939133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14939133C>T	ENST00000285046.5	+	5	2976	c.2866C>T	c.(2866-2868)Cat>Tat	p.H956Y	FGD5_ENST00000543601.1_Missense_Mutation_p.H715Y|FGD5_ENST00000476851.1_3'UTR	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	956	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCACGACCTTCATCAAGGCAT	0.587000													3	12					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2413244	2413244	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2413244G>A	ENST00000202625.2	+	13	2137	c.2076G>A	c.(2074-2076)ccG>ccA	p.P692P	TGM6_ENST00000381423.1_3'UTR	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	692					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CTCACTTCCCGGACATCAAGG	0.592000													38	117					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141794427	141794427	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141794427G>A	ENST00000475668.2	+	62	7368	c.7314G>A	c.(7312-7314)atG>atA	p.M2438I	MGAM_ENST00000549489.2_Missense_Mutation_p.M1542I			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1542					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CAGGCATGATGGAGTTCAGCC	0.552000													27	69					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48745123	48745123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48745123G>A	ENST00000427699.1	+	12	1720	c.1640G>A	c.(1639-1641)aGg>aAg	p.R547K	ABCC3_ENST00000285238.8_Intron	NM_001144070.1	NP_001137542.1	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	547	ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TTCCTGGTGAGGCTTGGCACA	0.662000													8	36					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075737	145075737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145075737G>A	ENST00000369359.4	-	1	164	c.126C>T	c.(124-126)tcC>tcT	p.S42S	PDE4DIP_ENST00000369345.4_Silent_p.S42S|PDE4DIP_ENST00000369348.3_Silent_p.S42S|PDE4DIP_ENST00000530740.1_Silent_p.S42S			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTGCCGTGGGGACTGAGGGG	0.736000			T	PDGFRB	MPD								12	109					0	0	1	0	0
SLC25A23	79085	broad.mit.edu	37	19	6452337	6452337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6452337G>A	ENST00000301454.4	-	8	1163	c.1057C>T	c.(1057-1059)Ctg>Ttg	p.L353L	SLC25A23_ENST00000334510.5_Silent_p.L353L|SLC25A23_ENST00000414491.2_Intron	NM_024103.2	NP_077008.2	Q9BV35	SCMC3_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	353					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|pancreas(1)|skin(1)	17						TAGACGGCCAGGTCGATGCCC	0.667000													3	28					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45782899	45782899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45782899C>T	ENST00000357450.4	-	11	1758	c.1759G>A	c.(1759-1761)Gag>Aag	p.E587K	SMC1B_ENST00000404354.3_Missense_Mutation_p.E587K	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	587	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCTTTAAGCTCCCTTAGTCTT	0.328000													26	100					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71683038	71683038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71683038C>T	ENST00000393524.2	-	17	4259	c.3526G>A	c.(3526-3528)Ggc>Agc	p.G1176S	PHLPP2_ENST00000540628.1_Intron|PHLPP2_ENST00000567016.1_Missense_Mutation_p.G1278S|PHLPP2_ENST00000356272.3_Missense_Mutation_p.G1243S|PHLPP2_ENST00000360429.3_Intron|PHLPP2_ENST00000568954.1_Missense_Mutation_p.G1243S			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	1243						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						ACAATAGAGCCATTGGAGAGT	0.522000													6	97					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699252	43699252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43699252G>A	ENST00000405312.3	-	4	1120	c.883C>T	c.(883-885)Ctc>Ttc	p.L295F	PSG4_ENST00000433626.2_Missense_Mutation_p.L202F|PSG4_ENST00000244295.9_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	295	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				GGTAGAATGAGGATCCTGTTT	0.478000													27	320					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34018600	34018600	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34018600G>A	ENST00000389232.4	+	46	6996	c.6926G>A	c.(6925-6927)gGa>gAa	p.G2309E	RYR3_ENST00000415757.3_Missense_Mutation_p.G2309E	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2309	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATCCAGACAGGAAAGGGGGAA	0.557000													3	19					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53686563	53686563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:53686563G>A	ENST00000262135.4	-	15	2129	c.2036C>T	c.(2035-2037)aCc>aTc	p.T679I	RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.T679I|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.T679I|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.T679I	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	679	C2 1.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				GACCTCAAGGGTGATAGTATT	0.363000													15	73					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95056388	95056388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95056388G>A	ENST00000329597.7	+	4	840	c.630G>A	c.(628-630)gaG>gaA	p.E210E	SERPINA5_ENST00000554866.1_Silent_p.E210E|SERPINA5_ENST00000553780.1_Silent_p.E210E|SERPINA5_ENST00000554276.1_Silent_p.E210E	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	210					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CTAAGTGGGAGACAAGCTTCA	0.433000													15	21					0	0	1	0	0
IRF2	3660	broad.mit.edu	37	4	185310027	185310027	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:185310027G>A	ENST00000393593.3	-	9	1142	c.935C>T	c.(934-936)cCc>cTc	p.P312L		NM_002199.3	NP_002190.2	P14316	IRF2_HUMAN	interferon regulatory factor 2	312					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	22		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		GGAAGAAAGGGGGAGGTCTTG	0.587000													36	72					0	0	1	0	0
ITPK1	3705	broad.mit.edu	37	14	93483113	93483113	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93483113G>A	ENST00000267615.6	-	4	327	c.154C>T	c.(154-156)Ccc>Tcc	p.P52S	ITPK1_ENST00000555495.1_5'UTR|ITPK1_ENST00000354313.3_Missense_Mutation_p.P52S|ITPK1_ENST00000556603.2_Missense_Mutation_p.P52S|ITPK1_ENST00000556954.1_5'UTR			Q13572	ITPK1_HUMAN	inositol-tetrakisphosphate 1-kinase	52					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)	11		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		ACGTCCAGGGGGCCCTGCTCC	0.572000													22	80					0	0	1	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090588	238090588	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:238090588G>A	ENST00000450451.1	+	0	2094					NR_027247.2																						GCATTGTCAGGGACTCTGGAG	0.612000													9	30					0	0	1	0	0
NSMCE4A	54780	broad.mit.edu	37	10	123730536	123730536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123730536G>A	ENST00000369023.3	-	3	470	c.419C>T	c.(418-420)gCt>gTt	p.A140V	NSMCE4A_ENST00000369017.5_Missense_Mutation_p.A140V|NSMCE4A_ENST00000538652.1_5'UTR|NSMCE4A_ENST00000489266.1_5'UTR	NM_001167865.1|NM_017615.2	NP_001161337.1|NP_060085.2	Q9NXX6	NSE4A_HUMAN	non-SMC element 4 homolog A (S. cerevisiae)	140										breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	6		all_neural(114;0.138)|Glioma(114;0.222)				CAAATCTGAAGCCAAAACAAG	0.393000													17	42					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142021316	142021316	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142021316C>T	ENST00000390381.3	+	0	605																											AATGTGAGCACCTTGGAGCTG	0.522000													14	71					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46916019	46916019	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46916019C>T	ENST00000307522.3	-	1	822	c.49G>A	c.(49-51)Gtc>Atc	p.V17I		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	17						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		gccagcctgacctcccggggg	0.602000													8	59					0	0	1	0	0
SLC22A8	9376	broad.mit.edu	37	11	62782276	62782276	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62782276G>A	ENST00000336232.2	-	2	290	c.155C>T	c.(154-156)cCc>cTc	p.P52L	SLC22A8_ENST00000535878.1_Intron|SLC22A8_ENST00000545207.1_Intron|SLC22A8_ENST00000430500.2_Missense_Mutation_p.P52L|SLC22A8_ENST00000311438.8_Missense_Mutation_p.P52L	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	52					response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						GGCATTGTGGGGCGGGCGACA	0.627000													97	161					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31477646	31477646	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31477646C>T	ENST00000408912.3	+	8	2846	c.2529C>T	c.(2527-2529)ccC>ccT	p.P843P	ARMC5_ENST00000563544.1_Silent_p.P748P|ARMC5_ENST00000457010.2_3'UTR|ARMC5_ENST00000268314.4_Silent_p.P748P|ARMC5_ENST00000412665.2_Silent_p.P392P|ARMC5_ENST00000538189.1_Silent_p.P780P			Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	748							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						TCCCAGCTCCCGACCTGCACT	0.667000													11	27					0	0	1	0	0
OR4D10	390197	broad.mit.edu	37	11	59245655	59245655	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59245655C>T	ENST00000530162.1	+	1	810	c.753C>T	c.(751-753)ttC>ttT	p.F251F		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F249L(1)		NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCCTGCATTTCGTGCCCTGCA	0.547000													77	186					0	0	1	0	0
SPRR2D	6703	broad.mit.edu	37	1	153012740	153012740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153012740G>A	ENST00000368757.1	-	2	363	c.83C>T	c.(82-84)cCa>cTa	p.P28L	SPRR2D_ENST00000368756.1_Missense_Mutation_p.P28L|SPRR2D_ENST00000360379.3_Missense_Mutation_p.P28L|SPRR2D_ENST00000368758.3_Missense_Mutation_p.P28L			P22532	SPR2D_HUMAN	small proline-rich protein 2D	28	3 X 9 AA tandem repeats of P-K-C-P-[EQ]- P-C-P-[PS].				keratinization	cornified envelope|cytoplasm				endometrium(1)|skin(1)	2	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTTCGGGGGTGGACATGGCTC	0.607000													51	138					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103467999	103467999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103467999C>T	ENST00000358392.2	-	23	2435	c.2118G>A	c.(2116-2118)ggG>ggA	p.G706G	COL11A1_ENST00000370096.3_Silent_p.G694G|COL11A1_ENST00000512756.1_Silent_p.G578G|COL11A1_ENST00000353414.4_Silent_p.G655G|COL11A1_ENST00000461720.1_5'UTR	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	694	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTCCTGGATTCCCTTGTTGAC	0.423000													5	9					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55862776	55862776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55862776G>A	ENST00000422046.2	-	2	441	c.160C>T	c.(160-162)Cct>Tct	p.P54S	CES1_ENST00000360526.3_Missense_Mutation_p.P55S|CES1_ENST00000361503.4_Missense_Mutation_p.P54S			P23141	EST1_HUMAN	carboxylesterase 1	54					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	TTGGCAAAAGGGATTCCCAGG	0.557000													7	38					0	0	1	0	0
TBC1D3F	84218	broad.mit.edu	37	17	36288274	36288274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:36288274G>A	ENST00000539424.1	+	2	1785	c.120G>A	c.(118-120)atG>atA	p.M40I	TBC1D3F_ENST00000327454.6_Missense_Mutation_p.M120I|TBC1D3F_ENST00000505415.1_Missense_Mutation_p.M120I|TBC1D3F_ENST00000378174.5_Missense_Mutation_p.M120I			A6NER0	TBC3F_HUMAN	TBC1 domain family, member 3F	120						intracellular	Rab GTPase activator activity			liver(1)|pancreas(1)	2						CTGAGGAAATGAAGTTGAAAA	0.557000													65	608					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056224	9056224	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9056224C>T	ENST00000397910.4	-	3	31425	c.31222G>A	c.(31222-31224)Gga>Aga	p.G10408R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10410	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCACTGTTCCCAGCTCAACG	0.478000													45	202					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201485454	201485454	+	Missense_Mutation	SNP	G	G	A	rs148848561		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:201485454G>A	ENST00000374700.2	+	17	2027	c.1786G>A	c.(1786-1788)Gag>Aag	p.E596K	AOX1_ENST00000485106.1_Intron	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	596					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TGCCACGGGGGAGGCCATCTA	0.458000													17	45					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2297430	2297430	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2297430C>T	ENST00000222990.3	-	8	966	c.924G>A	c.(922-924)caG>caA	p.Q308Q		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	308					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding	p.Q308H(1)		breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CGTTCTCTTCCTGCTTACCCT	0.612000													67	171					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182822450	182822450	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:182822450C>T	ENST00000367549.3	+	5	484	c.374C>T	c.(373-375)tCt>tTt	p.S125F		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	125	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						GAAAATAATTCTGAGGTAGGG	0.393000													28	75					0	0	1	0	0
SEC14L5	9717	broad.mit.edu	37	16	5040786	5040786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:5040786G>A	ENST00000251170.7	+	5	544	c.364G>A	c.(364-366)Gac>Aac	p.D122N		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	122	PRELI/MSF1.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						TGAGAATGAAGACTGGACTTG	0.572000													10	37					0	0	1	0	0
GNLY	10578	broad.mit.edu	37	2	85921566	85921566	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:85921566C>T	ENST00000263863.4	+	1	153	c.25C>T	c.(25-27)Ctt>Ttt	p.L9F	GNLY_ENST00000533041.1_3'UTR|GNLY_ENST00000524600.1_Missense_Mutation_p.L9F|GNLY_ENST00000409696.3_5'UTR	NM_006433.3	NP_006424.2	P22749	GNLY_HUMAN	granulysin	9					cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						CCTCCTGCTCCTTGCAGCCAT	0.617000													25	56					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6965357	6965357	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6965357G>A	ENST00000389658.3	-	50	7218	c.7125C>T	c.(7123-7125)acC>acT	p.T2375T		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2375	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGTCAAAAGGGTAATGGGTC	0.463000													40	93					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129284780	129284780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129284780G>A	ENST00000393239.1	-	24	4450	c.4272C>T	c.(4270-4272)atC>atT	p.I1424I	PLXND1_ENST00000324093.4_Silent_p.I1424I			Q9Y4D7	PLXD1_HUMAN	plexin D1	1424					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GGACAAAGACGATGAGGAAGT	0.557000													5	53					0	0	1	0	0
TET2	54790	broad.mit.edu	37	4	106155373	106155373	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:106155373G>A	ENST00000540549.1	+	3	1134	c.274G>A	c.(274-276)Gga>Aga	p.G92R	TET2_ENST00000413648.2_Missense_Mutation_p.G92R|TET2_ENST00000394764.1_Missense_Mutation_p.G92R|TET2_ENST00000545826.1_Missense_Mutation_p.G92R|TET2_ENST00000513237.1_Missense_Mutation_p.G113R|TET2_ENST00000305737.2_Missense_Mutation_p.G92R|TET2_ENST00000380013.4_Missense_Mutation_p.G92R			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	92					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TTTGCAAAATGGAGGAATAAA	0.403000			"""Mis N, F"""		MDS								28	72					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	51254667	51254667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:51254667C>T	ENST00000404971.1	-	2	2084	c.745G>A	c.(745-747)Ggc>Agc	p.G249S	NRXN1_ENST00000405581.1_Missense_Mutation_p.G249S|NRXN1_ENST00000402717.3_Missense_Mutation_p.G249S|NRXN1_ENST00000401669.2_Missense_Mutation_p.G249S|NRXN1_ENST00000406859.3_Missense_Mutation_p.G249S|NRXN1_ENST00000405472.3_Missense_Mutation_p.G249S|NRXN1_ENST00000406316.2_Missense_Mutation_p.G249S	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	249	EGF-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCGCGGAAGCCGGTTCGCGAG	0.756000													9	28					0	0	1	0	0
LOC344967	344967	broad.mit.edu	37	4	40045360	40045360	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40045360G>A	ENST00000381811.2	-	0	789					NR_027277.1																						CACAACAGGAGGCTCTTCGAG	0.577000													12	17					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8485972	8485972	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8485972C>T	ENST00000381196.4	-	25	3388	c.2845G>A	c.(2845-2847)Ggc>Agc	p.G949S	PTPRD_ENST00000358503.5_Missense_Mutation_p.G927S|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.G949S|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.G949S|PTPRD_ENST00000360074.4_Missense_Mutation_p.G936S|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000355233.5_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	949	Fibronectin type-III 7.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GTGATAATGCCATTTCTCTCT	0.478000										TSP Lung(15;0.13)			10	91					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20554523	20554523	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20554523C>T	ENST00000329697.6	-	11	1511	c.1343G>A	c.(1342-1344)gGa>gAa	p.G448E	ACSM2B_ENST00000565232.1_Missense_Mutation_p.G448E|ACSM2B_ENST00000565322.1_Missense_Mutation_p.G369E|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G448E	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	448					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						ATCTTTGATTCCCCGGTCTCC	0.488000													15	309					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674254	4674254	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4674254C>T	ENST00000396952.5	+	2	1148	c.498C>T	c.(496-498)atC>atT	p.I166I	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I165M(2)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTCTTCATCAAGCAGCTGC	0.552000													41	127					0	0	1	0	0
HIST1H3I	8354	broad.mit.edu	37	6	27839863	27839863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:27839863C>T	ENST00000328488.2	-	1	236	c.231G>A	c.(229-231)caG>caA	p.Q77Q		NM_003533.2	NP_003524.1	P68431	H31_HUMAN	histone cluster 1, H3i	77					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TCTTAAAGTCCTGTGCGATCT	0.612000													19	128					0	0	1	0	0
TRIB3	57761	broad.mit.edu	37	20	377122	377122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:377122C>T	ENST00000217233.3	+	4	1418	c.865C>T	c.(865-867)Cgc>Tgc	p.R289C	TRIB3_ENST00000422053.2_Missense_Mutation_p.R316C	NM_021158.3	NP_066981.2	Q96RU7	TRIB3_HUMAN	tribbles pseudokinase 3	289	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|skin(1)	21		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GGCCCCTGCCCGCTGTCTGGT	0.692000													36	85					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8404586	8404586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8404586C>T	ENST00000381196.4	-	33	4704	c.4161G>A	c.(4159-4161)gcG>gcA	p.A1387A	PTPRD_ENST00000358503.5_Silent_p.A1365A|PTPRD_ENST00000397611.3_Silent_p.A977A|PTPRD_ENST00000356435.5_Silent_p.A1387A|PTPRD_ENST00000397617.3_Silent_p.A980A|PTPRD_ENST00000397606.3_Silent_p.A980A|PTPRD_ENST00000540109.1_Silent_p.A1387A|PTPRD_ENST00000360074.4_Silent_p.A1374A|PTPRD_ENST00000486161.1_Silent_p.A980A|PTPRD_ENST00000537002.1_Silent_p.A977A|PTPRD_ENST00000355233.5_Silent_p.A981A	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1387	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CGATTACATTCGCGTATCTAT	0.378000										TSP Lung(15;0.13)			13	42					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206610476	206610476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206610476G>A	ENST00000360409.3	+	10	2439	c.1648G>A	c.(1648-1650)Gaa>Aaa	p.E550K	NRP2_ENST00000540178.1_Missense_Mutation_p.E550K|NRP2_ENST00000357785.5_Missense_Mutation_p.E550K|NRP2_ENST00000412873.2_Missense_Mutation_p.E550K|NRP2_ENST00000272849.3_Missense_Mutation_p.E550K|NRP2_ENST00000540841.1_Missense_Mutation_p.E550K|NRP2_ENST00000357118.4_Missense_Mutation_p.E550K	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	550	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GCAGCTGTTCGAAGGGAACAT	0.607000													12	28					0	0	1	0	0
SAMD8	142891	broad.mit.edu	37	10	76910586	76910586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76910586C>T	ENST00000542569.1	+	2	403	c.300C>T	c.(298-300)ttC>ttT	p.F100F	SAMD8_ENST00000372687.3_Silent_p.F100F|SAMD8_ENST00000372690.3_Silent_p.F163F	NM_001174156.1|NM_144660.2	NP_001167627.1|NP_653261.1	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	100					sphingomyelin biosynthetic process	integral to membrane				NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	12	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TGACCCCTTTCATCAGTGCTC	0.448000													32	86					0	0	1	0	0
GZMA	3001	broad.mit.edu	37	5	54403991	54403991	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54403991C>T	ENST00000274306.6	+	4	431	c.396C>T	c.(394-396)atC>atT	p.I132I		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	132	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				ATGTGACTATCCTTCATCTAC	0.373000													9	43					0	0	1	0	0
CLDN12	9069	broad.mit.edu	37	7	90042413	90042413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:90042413C>T	ENST00000535571.1	+	2	732	c.423C>T	c.(421-423)ttC>ttT	p.F141F	CLDN12_ENST00000287916.4_Silent_p.F141F|CLDN12_ENST00000394605.2_Silent_p.F141F	NM_001185072.2	NP_001172001.1	P56749	CLD12_HUMAN	claudin 12	141					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			breast(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)	15						TGCTATTTTTCCTGGCAGGTA	0.493000													50	114					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135482015	135482015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135482015G>A	ENST00000394143.1	+	21	8606	c.8315G>A	c.(8314-8316)cGa>cAa	p.R2772Q	GPR112_ENST00000370652.1_Missense_Mutation_p.R2772Q|GPR112_ENST00000287534.4_Missense_Mutation_p.R2525Q|GPR112_ENST00000394141.1_Missense_Mutation_p.R2567Q|GPR112_ENST00000412101.1_Missense_Mutation_p.R2567Q	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2772					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AGCAAACTTCGAAAAGATTAT	0.318000													26	22					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045045	87045045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87045045G>A	ENST00000370563.3	+	13	2173	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	711						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AGGGGAAATTGAAGCAAACCC	0.413000													27	48					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100261751	100261751	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100261751C>T	ENST00000515683.1	-	0	1296					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	TAGCTCCTTTCCACGTGCGTC	0.438000													69	203					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141243024	141243024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141243024C>T	ENST00000389484.3	-	59	10284	c.9313G>A	c.(9313-9315)Gac>Aac	p.D3105N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3105					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTCTGTGTCAGACCAATAG	0.393000										TSP Lung(27;0.18)			29	56					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56271348	56271348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56271348C>T	ENST00000225371.5	+	5	599	c.489C>T	c.(487-489)tcC>tcT	p.S163S		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	163				S -> C (in Ref. 3; AA sequence).	hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						TAGGGGCCTCCAACCAGGCTC	0.667000													16	41					0	0	1	0	0
ALG1	56052	broad.mit.edu	37	16	5125427	5125427	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:5125427C>T	ENST00000588623.1	+	5	1196	c.96C>T	c.(94-96)ttC>ttT	p.F32F	ALG1_ENST00000262374.5_Silent_p.F143F|ALG1_ENST00000544428.1_Silent_p.F32F			Q9BT22	ALG1_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase	143					dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(90;0.0164)				TCTGCTGGTTCGTGGGCTGCC	0.542000													46	130					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22040797	22040797	+	Missense_Mutation	SNP	G	G	A	rs75460545	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:22040797G>A	ENST00000261200.4	-	13	1873	c.1874C>T	c.(1873-1875)tCg>tTg	p.S625L	ABCC9_ENST00000261201.4_Missense_Mutation_p.S625L|ABCC9_ENST00000345162.2_Missense_Mutation_p.S625L|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	625					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.S625L(1)		NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAAAGGAAGCGAACTTTCACC	0.398000													24	91					0	0	1	0	0
CCT7	10574	broad.mit.edu	37	2	73476202	73476202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73476202C>T	ENST00000539919.1	+	9	1106	c.735C>T	c.(733-735)gtC>gtT	p.V245V	CCT7_ENST00000537131.1_Silent_p.V189V|CCT7_ENST00000398422.2_Silent_p.V85V|CCT7_ENST00000258091.5_Silent_p.V289V|CCT7_ENST00000473786.1_3'UTR|CCT7_ENST00000538797.1_Silent_p.V161V|CCT7_ENST00000540468.1_Silent_p.V202V	NM_001166285.1	NP_001159757.1	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 (eta)	289					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding			breast(1)|cervix(1)|endometrium(1)|lung(3)|stomach(1)	7						CCAAAGTTGTCTTGTCCAAAC	0.483000													19	58					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55496418	55496418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55496418C>T	ENST00000543010.1	+	7	2177	c.2034C>T	c.(2032-2034)tcC>tcT	p.S678S	NLRP2_ENST00000263437.6_Silent_p.S675S|NLRP2_ENST00000537859.1_Silent_p.S656S|NLRP2_ENST00000391721.4_Silent_p.S654S|NLRP2_ENST00000448584.2_Silent_p.S678S|NLRP2_ENST00000339757.7_Silent_p.S656S|NLRP2_ENST00000538819.1_Silent_p.S654S|NLRP2_ENST00000427260.2_Silent_p.S655S	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	678					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CCTATAGATCCCAGGATGATC	0.433000													46	99					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72846493	72846493	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72846493G>A	ENST00000293190.5	-	6	1489	c.1343C>T	c.(1342-1344)cCc>cTc	p.P448L	GRIN2C_ENST00000347612.4_Missense_Mutation_p.P448L	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	448					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CTTGGTGTAGGGGGCCACGTC	0.622000													32	119					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814304	106814304	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106814304G>A	ENST00000407775.2	+	8	2244	c.1994G>A	c.(1993-1995)gGa>gAa	p.G665E	ZFPM2_ENST00000520492.1_Missense_Mutation_p.G533E|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.G396E|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.G533E|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	665					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AAAATTAATGGAAAACCTGTT	0.433000													8	30					0	0	1	0	0
PLEKHG7	440107	broad.mit.edu	37	12	93134671	93134671	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:93134671C>T	ENST00000344636.3	+	3	230	c.46C>T	c.(46-48)Ctc>Ttc	p.L16F	PLEKHG7_ENST00000549856.1_Missense_Mutation_p.L16F	NM_001004330.2	NP_001004330.1	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	16	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)	17						TCATGAATATCTCCTAGATGT	0.323000													16	50					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30898307	30898307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30898307C>T	ENST00000375712.3	+	2	894	c.727C>T	c.(727-729)Ctt>Ttt	p.L243F	KIF3B_ENST00000418717.2_5'UTR	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	243	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AAAATTGAACCTTGTAGATCT	0.512000													23	42					0	0	1	0	0
HIATL1	84641	broad.mit.edu	37	9	97209106	97209106	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:97209106C>T	ENST00000375344.3	+	7	1000	c.729_splice	c.e7-1	p.S244_splice	HIATL1_ENST00000428393.2_Splice_Site_p.S179_splice	NM_032558.2	NP_115947.2	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	244					transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	11		Acute lymphoblastic leukemia(62;0.136)				TATTCTCAGTCGTTGAAGAAA	0.353000													15	68					0	0	1	0	0
KIF5B	3799	broad.mit.edu	37	10	32320161	32320161	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:32320161A>G	ENST00000302418.4	-	14	1878	c.1421T>C	c.(1420-1422)cTg>cCg	p.L474P		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	474					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				AAGGCGATTCAGCTCAGCTTG	0.373000			T	"""RET, ALK"""	NSCLC								13	50					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248005088	248005088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248005088C>T	ENST00000355784.2	-	1	166	c.111G>A	c.(109-111)ctG>ctA	p.L37L		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L37L(2)		NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CTATAATGGTCAGGCAGTAGA	0.493000													11	36					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507941	155507941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155507941G>A	ENST00000302053.3	-	5	718	c.640C>T	c.(640-642)Ccc>Tcc	p.P214S	FGA_ENST00000403106.3_Missense_Mutation_p.P214S	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	214					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCTCTAGAGGGAAGTAAGTCT	0.453000													40	85					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72346896	72346896	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72346896G>A	ENST00000389916.4	+	12	1577	c.1439G>A	c.(1438-1440)cGa>cAa	p.R480Q		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	480					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						GAGGAGCAGCGAAAGGAGTGC	0.647000													27	89					0	0	1	0	0
SMEK2	57223	broad.mit.edu	37	2	55792097	55792097	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:55792097G>A	ENST00000272313.5	-	12	2088	c.1761C>T	c.(1759-1761)ttC>ttT	p.F587F	SMEK2_ENST00000345102.5_Silent_p.F672F|SMEK2_ENST00000407823.3_Silent_p.F640F	NM_020463.2	NP_065196.1	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 (Dictyostelium)	672						microtubule organizing center|nucleus	protein binding			kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TCAATCCTTTGAATGTCTGAA	0.308000													13	34					0	0	1	0	0
TTC1	7265	broad.mit.edu	37	5	159492045	159492045	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:159492045C>T	ENST00000231238.5	+	8	962	c.852C>T	c.(850-852)ttC>ttT	p.F284F	TTC1_ENST00000520274.1_3'UTR|TTC1_ENST00000522793.1_Silent_p.F284F	NM_003314.1	NP_003305.1	Q99614	TTC1_HUMAN	tetratricopeptide repeat domain 1	284					protein folding		unfolded protein binding	p.F284L(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|prostate(1)|skin(1)	12	Renal(175;0.00196)	all_hematologic(541;0.00014)|Breast(839;0.0101)|all_neural(177;0.0281)|Medulloblastoma(196;0.0425)|Lung NSC(249;0.119)|all_lung(500;0.163)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	Epithelial(171;8.37e-05)|all cancers(165;0.000694)|OV - Ovarian serous cystadenocarcinoma(192;0.0402)		CCATCAATTTCGTTCAAAATC	0.423000													11	72					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92647601	92647601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:92647601C>T	ENST00000318445.6	+	4	1052	c.838C>T	c.(838-840)Ctc>Ttc	p.L280F	SLCO3A1_ENST00000424469.2_Missense_Mutation_p.L280F|SLCO3A1_ENST00000555549.1_3'UTR	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	280					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CTTCTCTTCCCTCTTGATGTT	0.577000													12	225					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43680245	43680245	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43680245C>T	ENST00000404580.1	-	3	574	c.486G>A	c.(484-486)aaG>aaA	p.K162K	PSG5_ENST00000366175.3_Silent_p.K162K|PSG5_ENST00000407356.1_Silent_p.K162K|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000342951.6_Silent_p.K162K|PSG5_ENST00000599812.1_Silent_p.K255K			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	162	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				CTAAGACATCCTTATTCTCCC	0.493000													92	262					0	0	1	0	0
NKAIN1	79570	broad.mit.edu	37	1	31656841	31656841	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:31656841G>A	ENST00000373736.2	-	4	300	c.294C>T	c.(292-294)acC>acT	p.T98T	NKAIN1_ENST00000263693.1_Silent_p.T54T|NKAIN1_ENST00000398657.2_Silent_p.T27T	NM_024522.2	NP_078798.2	Q4KMZ8	NKAI1_HUMAN	Na+/K+ transporting ATPase interacting 1	98						integral to membrane|plasma membrane				breast(1)|cervix(1)|endometrium(1)|kidney(2)|ovary(1)|prostate(1)	7		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|Breast(348;0.141)|all_neural(195;0.146)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0184)|READ - Rectum adenocarcinoma(331;0.148)		ATGTGTTGAAGGTCATGATGA	0.612000											OREG0004725	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	23					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914285	107914285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107914285G>A	ENST00000280758.5	+	2	1685	c.1157G>A	c.(1156-1158)aGc>aAc	p.S386N	BTBD11_ENST00000420571.2_Missense_Mutation_p.S386N|BTBD11_ENST00000490090.2_Missense_Mutation_p.S386N	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	386						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CTACCAGACAGCCTGAATCTT	0.527000													30	125					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23692817	23692817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:23692817C>T	ENST00000397312.2	-	7	1092	c.818G>A	c.(817-819)gGa>gAa	p.G273E	ELAVL2_ENST00000223951.6_Missense_Mutation_p.G260E|ELAVL2_ENST00000544538.1_Missense_Mutation_p.G273E|ELAVL2_ENST00000380110.4_Missense_Mutation_p.G303E|ELAVL2_ENST00000380117.1_Missense_Mutation_p.G273E	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	273					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CCACCCTGTTCCAGGGTGCCC	0.463000													6	74					0	0	1	0	0
CUL3	8452	broad.mit.edu	37	2	225365136	225365136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:225365136G>A	ENST00000264414.4	-	11	1892	c.1554C>T	c.(1552-1554)gcC>gcT	p.A518A	CUL3_ENST00000344951.4_Silent_p.A452A|CUL3_ENST00000409096.1_Silent_p.A494A|CUL3_ENST00000409777.1_Silent_p.A494A	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	518					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ACTTTGGTGTGGCTGACTGAG	0.428000													52	121					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66479210	66479210	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:66479210C>T	ENST00000256447.4	-	3	1618	c.1461G>A	c.(1459-1461)acG>acA	p.T487T		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	487					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		GGTTGGTCTTCGTGATAGTCC	0.483000													22	53					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6061852	6061852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6061852G>A	ENST00000379959.3	-	5	809	c.636C>T	c.(634-636)tcC>tcT	p.S212S	IL2RA_ENST00000256876.6_Silent_p.S203S|IL2RA_ENST00000379954.1_Silent_p.S140S	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	212					cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TGACGAGGCAGGAAGTCTCAC	0.577000													35	86					0	0	1	0	0
LINGO4	339398	broad.mit.edu	37	1	151774528	151774528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151774528C>T	ENST00000368820.3	-	2	1590	c.653G>A	c.(652-654)aGg>aAg	p.R218K		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	218						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGCTGGCAGCCTCCCAATATC	0.657000													26	80					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124333366	124333366	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124333366C>T	ENST00000409039.3	+	33	5710	c.5685C>T	c.(5683-5685)tcC>tcT	p.S1895S		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1895	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTGTGCTCTCCGTGATCTCCT	0.542000													6	21					0	0	1	0	0
PATZ1	23598	broad.mit.edu	37	22	31740842	31740842	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31740842G>A	ENST00000266269.5	-	1	1376	c.747C>T	c.(745-747)tcC>tcT	p.S249S	PATZ1_ENST00000215919.3_Silent_p.S249S|PATZ1_ENST00000351933.4_Silent_p.S249S|PATZ1_ENST00000405309.3_Silent_p.S249S	NM_014323.2	NP_055138.2	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	249					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(2)	12						TGGGGAATGGGGAAGTCAGCA	0.642000													4	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083067	9083067	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9083067G>A	ENST00000397910.4	-	1	8951	c.8748C>T	c.(8746-8748)acC>acT	p.T2916T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2917	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTCTGGAATGGTGTTCAGGG	0.483000													17	45					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149500802	149500802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149500802C>T	ENST00000261799.4	-	17	2897	c.2428G>A	c.(2428-2430)Gtg>Atg	p.V810M		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	810	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCATTGGCCACCTGGTAGCTG	0.597000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								16	49					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75442037	75442037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:75442037G>A	ENST00000549446.1	-	4	2356	c.1676C>T	c.(1675-1677)cCc>cTc	p.P559L	KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000298972.1_Missense_Mutation_p.P559L|KCNC2_ENST00000341669.3_Missense_Mutation_p.P559L|KCNC2_ENST00000548513.1_Missense_Mutation_p.P559L|KCNC2_ENST00000393288.2_Missense_Mutation_p.P559L|KCNC2_ENST00000540018.1_Intron|KCNC2_ENST00000550433.1_Missense_Mutation_p.P559L|KCNC2_ENST00000350228.2_Intron	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	559					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						GCGTCTGATGGGGAGCCTTTC	0.507000													49	67					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44611651	44611651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44611651C>T	ENST00000336976.6	+	6	1592	c.1338C>T	c.(1336-1338)caC>caT	p.H446H	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	446					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				TTGACTTTCACCAGCGCGTCC	0.463000													15	101					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74480229	74480229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:74480229G>A	ENST00000394019.2	-	15	1537	c.1140C>T	c.(1138-1140)gcC>gcT	p.A380A	SLC4A5_ENST00000346834.4_Silent_p.A380A|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Silent_p.A380A|SLC4A5_ENST00000377634.4_Silent_p.A380A|SLC4A5_ENST00000359484.4_Silent_p.A316A|SLC4A5_ENST00000357822.5_Silent_p.A380A|SLC4A5_ENST00000358683.4_Silent_p.A316A|RP11-287D1.3_ENST00000451608.2_3'UTR|SLC4A5_ENST00000423644.1_Silent_p.A380A	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	380						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CCCGATTGCGGGCTTTGTAGG	0.512000													19	43					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3329121	3329121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3329121C>T	ENST00000378398.3	+	10	2445	c.2363C>T	c.(2362-2364)cCc>cTc	p.P788L	PRDM16_ENST00000378391.2_Missense_Mutation_p.P787L|PRDM16_ENST00000270722.5_Missense_Mutation_p.P787L|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Missense_Mutation_p.P787L|PRDM16_ENST00000441472.2_Missense_Mutation_p.P787L|PRDM16_ENST00000514189.1_Missense_Mutation_p.P788L|PRDM16_ENST00000511072.1_Missense_Mutation_p.P788L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	787	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCCATCCTGCCCATGCCCAAG	0.711000			T	EVI1	"""MDS, AML"""								6	62					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91805699	91805699	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91805699G>A	ENST00000389857.6	-	8	818	c.732C>T	c.(730-732)ctC>ctT	p.L244L		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	244					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTTCGCTAGAGAGGCTGCTGG	0.657000													7	27					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238441	3238441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3238441C>T	ENST00000217939.6	-	5	5439	c.5285G>A	c.(5284-5286)aGa>aAa	p.R1762K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1762						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AATAACTTTTCTCTCTCTCAT	0.512000													19	11					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123811000	123811000	+	Missense_Mutation	SNP	G	G	A	rs142766960		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123811000G>A	ENST00000307033.2	+	1	751	c.677G>A	c.(676-678)cGa>cAa	p.R226Q		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GTCATGCTCCGAAGCCACTCA	0.507000													68	253					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167823624	167823624	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167823624C>T	ENST00000367848.1	-	18	2496	c.1999G>A	c.(1999-2001)Gaa>Aaa	p.E667K	ADCY10_ENST00000545172.1_Missense_Mutation_p.E606K|ADCY10_ENST00000367851.4_Missense_Mutation_p.E759K			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	759					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTTGTCTTTTCCTCAGACTCC	0.438000													39	121					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169787178	169787178	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169787178C>G	ENST00000263817.6	-	25	3532	c.3408G>C	c.(3406-3408)aaG>aaC	p.K1136N		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1136	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GGCTTACCACCTTCCCTTGAT	0.463000													7	25					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99448892	99448892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99448892C>T	ENST00000397899.2	-	5	790	c.459G>A	c.(457-459)atG>atA	p.M153I	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like																		CCTCAGAGCTCATGCCGGCAT	0.572000													30	54					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878874	24878874	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24878874C>T	ENST00000382554.3	+	4	2192	c.1874C>T	c.(1873-1875)cCc>cTc	p.P625L		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	625					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCAAAAACTCCCCAGGCTCAG	0.502000													5	12					0	0	1	0	0
FGF19	9965	broad.mit.edu	37	11	69514115	69514115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:69514115G>A	ENST00000294312.3	-	3	1331	c.566C>T	c.(565-567)tCt>tTt	p.S189F		NM_005117.2	NP_005108.1	O95750	FGF19_HUMAN	fibroblast growth factor 19	189					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			large_intestine(2)|lung(2)|skin(2)	6	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			CAGGGGCGAAGAGAACATGTC	0.577000													34	95					0	0	1	0	0
OR4F6	390648	broad.mit.edu	37	15	102346082	102346082	+	Missense_Mutation	SNP	C	C	T	rs141580524	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:102346082C>T	ENST00000328882.4	+	1	181	c.160C>T	c.(160-162)Cgt>Tgt	p.R54C		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTCTGACCCTCGTTTACAGTC	0.468000													259	325					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15579516	15579516	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15579516C>T	ENST00000340880.4	-	5	2169	c.1689G>A	c.(1687-1689)agG>agA	p.R563R	PGLYRP2_ENST00000292609.4_3'UTR	NM_052890.3	NP_443122.3	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	563					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						GGGGTGGCTCCCTCCTGGATC	0.517000													19	65					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055504	75055504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75055504C>T	ENST00000326665.5	-	12	2205	c.1987G>A	c.(1987-1989)Gaa>Aaa	p.E663K	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.E466K	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	663	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCAAAGCTTTCGTCTATTGGC	0.408000													26	108					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7750676	7750676	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7750676C>T	ENST00000254846.5	+	10	1552	c.1163C>T	c.(1162-1164)tCc>tTc	p.S388F	KDM6B_ENST00000448097.2_Missense_Mutation_p.S388F	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	388	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						TACGCCCCTTCCCGGCCCCCT	0.657000													75	88					0	0	1	0	0
PDE10A	10846	broad.mit.edu	37	6	165749672	165749672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:165749672G>A	ENST00000366882.1	-	22	2331	c.2177C>T	c.(2176-2178)cCc>cTc	p.P726L	PDE10A_ENST00000354448.4_Missense_Mutation_p.P726L|PDE10A_ENST00000539869.2_Missense_Mutation_p.P736L			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	726					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TGTATAGCAGGGAATGGCCAC	0.443000													9	17					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63044633	63044633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:63044633G>A	ENST00000251157.5	-	17	1909	c.1876C>T	c.(1876-1878)Cct>Tct	p.P626S	DOCK7_ENST00000340370.5_Missense_Mutation_p.P626S	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	626	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TGAAAATCAGGAGACCTTCAT	0.254000													30	66					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	133119350	133119350	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:133119350G>A	ENST00000370818.3	-	1	572	c.127C>T	c.(127-129)Cag>Tag	p.Q43*	GPC3_ENST00000394299.2_Nonsense_Mutation_p.Q43*|GPC3_ENST00000543339.1_Nonsense_Mutation_p.Q43*	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	43						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					TGCAGTCTCTGGAAGAAGGAG	0.692000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				7	6					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121767694	121767694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121767694G>A	ENST00000261367.7	+	8	2782	c.1354G>A	c.(1354-1356)Gtg>Atg	p.V452M	SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379538.3_Missense_Mutation_p.V39M|SNCAIP_ENST00000379533.2_Missense_Mutation_p.V452M|SNCAIP_ENST00000503116.2_Missense_Mutation_p.V452M|SNCAIP_ENST00000261368.8_Missense_Mutation_p.V405M|SNCAIP_ENST00000379536.2_Missense_Mutation_p.V345M|SNCAIP_ENST00000542191.1_5'UTR|SNCAIP_ENST00000504884.2_3'UTR			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	405					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACGCTGGATGGTGAGCGAAAC	0.403000													8	41					0	0	1	0	0
KLHL12	59349	broad.mit.edu	37	1	202861744	202861744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202861744G>A	ENST00000367261.3	-	12	1842	c.1624C>T	c.(1624-1626)Cct>Tct	p.P542S	KLHL12_ENST00000367259.1_3'UTR|KLHL12_ENST00000435533.3_Missense_Mutation_p.P580S	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	542	Interaction with DVL3.				Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			TCGATGATAGGGTCATAACAT	0.493000													13	59					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179516823	179516823	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179516823C>T	ENST00000589042.1	-	204	39519	c.39295_splice	c.e204+1	p.V13099_splice	TTN_ENST00000342992.6_Splice_Site_p.V10665_splice|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Splice_Site_p.V11592_splice|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11452			Q -> R (in a lung small cell carcinoma sample; somatic mutation).				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATTATTACCTTCAGGGGGA	0.353000													34	87					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44589351	44589351	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44589351G>A	ENST00000322927.2	-	12	1786	c.1686C>T	c.(1684-1686)ttC>ttT	p.F562F	ZNF335_ENST00000426788.1_Silent_p.F407F	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				CAGGGCAGGGGAAAGAGCTCA	0.557000													30	92					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831429	61831429	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61831429G>A	ENST00000280772.1	-	37	9401	c.9210C>T	c.(9208-9210)ccC>ccT	p.P3070P	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3070					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ATCCATCAATGGGACTGTGGT	0.468000													40	139					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603157	111603157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111603157G>A	ENST00000431670.2	+	2	644	c.233G>A	c.(232-234)aGt>aAt	p.S78N	PHLDB2_ENST00000393925.3_Missense_Mutation_p.S78N|PHLDB2_ENST00000393923.3_Missense_Mutation_p.S105N|PHLDB2_ENST00000478922.1_Missense_Mutation_p.S78N|PHLDB2_ENST00000481953.1_Missense_Mutation_p.S78N|PHLDB2_ENST00000477695.1_Missense_Mutation_p.S78N|PHLDB2_ENST00000412622.1_Missense_Mutation_p.S78N	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	78						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TTGGGAACCAGTGTCAGAAGC	0.453000													24	258					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49585897	49585897	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49585897G>A	ENST00000371175.4	-	3	402	c.376C>T	c.(376-378)Ctg>Ttg	p.L126L	RHAG_ENST00000229810.7_Silent_p.L126L	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	126					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					AAAGATATCAGAACTGTGGCT	0.403000													16	33					0	0	1	0	0
ICAM4	3386	broad.mit.edu	37	19	10398444	10398444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10398444C>T	ENST00000393717.2	+	2	636	c.627C>T	c.(625-627)atC>atT	p.I209I	ICAM4_ENST00000380770.3_Silent_p.I209I|ICAM4_ENST00000340992.4_Silent_p.L184L|CTD-2369P2.8_ENST00000589379.1_RNA	NM_022377.3	NP_071772.1	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	209	Ig-like C2-type 2.				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			breast(1)|large_intestine(3)|lung(2)|pancreas(1)	7			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			AGCCCGTGATCTGCCACGCGC	0.627000													9	94					0	0	1	0	0
NDUFAF1	51103	broad.mit.edu	37	15	41679779	41679779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41679779C>T	ENST00000260361.4	-	5	1228	c.847G>A	c.(847-849)Gga>Aga	p.G283R		NM_016013.3	NP_057097.2	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1	283					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	12		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		AAGGTGAATCCTATAGAAGAG	0.358000													17	67					0	0	1	0	0
CD63	967	broad.mit.edu	37	12	56121019	56121019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56121019G>A	ENST00000549117.1	-	3	607	c.171C>T	c.(169-171)atC>atT	p.I57I	CD63_ENST00000257857.4_Silent_p.I57I|CD63_ENST00000420846.3_Silent_p.I57I|CD63_ENST00000552692.1_Silent_p.I57I|CD63_ENST00000552754.1_Silent_p.I34I|CD63_ENST00000546939.1_5'UTR|CD63_ENST00000550776.1_5'UTR	NM_001257389.1	NP_001244318.1	P08962	CD63_HUMAN	CD63 molecule	57					platelet activation|platelet degranulation	integral to plasma membrane|late endosome membrane|lysosomal membrane|platelet dense granule membrane				kidney(1)|large_intestine(3)|lung(2)|ovary(1)	7						CCACTGCGATGATGACCACTG	0.592000													34	132					0	0	1	0	0
TTC29	83894	broad.mit.edu	37	4	147795922	147795922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:147795922C>T	ENST00000513335.1	-	8	1022	c.823G>A	c.(823-825)Gaa>Aaa	p.E275K	TTC29_ENST00000398886.4_Missense_Mutation_p.E275K|TTC29_ENST00000325106.4_Missense_Mutation_p.E249K			Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	249							binding			breast(2)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					TGTTTGTATTCTTTATTTTCT	0.403000													6	21					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52509050	52509050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52509050G>A	ENST00000242839.4	-	21	4396	c.4240C>T	c.(4240-4242)Ccc>Tcc	p.P1414S	ATP7B_ENST00000418097.2_Missense_Mutation_p.P1349S|ATP7B_ENST00000344297.5_Missense_Mutation_p.P1207S|ATP7B_ENST00000448424.2_Missense_Mutation_p.P1336S|ATP7B_ENST00000417240.2_Missense_Mutation_p.P625S|ATP7B_ENST00000400370.3_Missense_Mutation_p.P984S|ATP7B_ENST00000400366.3_Missense_Mutation_p.P1303S	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1414					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GTGGCCCTGGGGGAGTCCCGC	0.632000									Wilson disease				22	52					0	0	1	0	0
RETN	56729	broad.mit.edu	37	19	7734761	7734761	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7734761G>A	ENST00000221515.2	+	3	261	c.173G>A	c.(172-174)gGg>gAg	p.G58E	RETN_ENST00000381324.2_Intron	NM_001193374.1|NM_020415.3	NP_001180303.1|NP_065148.1	Q9HD89	RETN_HUMAN	resistin	58							hormone activity			ovary(1)	1						ACCTCCAGGGGGGACCTGGCT	0.617000													15	33					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7287996	7287996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7287996G>A	ENST00000537408.1	+	3	1031	c.493G>A	c.(493-495)Gct>Act	p.A165T	CLSTN3_ENST00000266546.6_Missense_Mutation_p.A153T			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	153	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GTATCGTGCGGCTGTGACAGA	0.562000													26	56					0	0	1	0	0
SPATA9	83890	broad.mit.edu	37	5	95018270	95018270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:95018270C>T	ENST00000274432.8	-	2	253	c.112G>A	c.(112-114)Gaa>Aaa	p.E38K	SPATA9_ENST00000477047.2_5'UTR|SPATA9_ENST00000395899.3_Missense_Mutation_p.E38K|RFESD_ENST00000508206.1_Intron	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	38					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		GTGGGAAATTCATCTTTAAAC	0.313000													23	66					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231201	7231201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:7231201G>A	ENST00000383467.2	+	1	79	c.65G>A	c.(64-66)gGg>gAg	p.G22E		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	22										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CTGTTCACGGGGAGGAGACAG	0.617000													10	79					0	0	1	0	0
AMTN	401138	broad.mit.edu	37	4	71388496	71388496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71388496C>T	ENST00000339336.4	+	3	209	c.79C>T	c.(79-81)Cct>Tct	p.P27S	AMTN_ENST00000504451.1_Missense_Mutation_p.P26S	NM_212557.2	NP_997722.1	Q6UX39	AMTN_HUMAN	amelotin	27					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				NS(3)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)|skin(1)	19			Lung(101;0.235)			TTTGGGACTCCCTCCCACAAA	0.423000													70	237					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36166573	36166573	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36166573G>A	ENST00000303965.4	-	11	2625	c.2136C>T	c.(2134-2136)tcC>tcT	p.S712S		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	712	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGAGATTGATGGATGCCCAGT	0.428000													11	95					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88284477	88284477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:88284477G>A	ENST00000357081.3	-	8	729	c.585C>T	c.(583-585)tcC>tcT	p.S195S	AGTPBP1_ENST00000337006.4_Silent_p.S137S|AGTPBP1_ENST00000376109.3_Silent_p.S247S|AGTPBP1_ENST00000376080.1_Silent_p.S137S|AGTPBP1_ENST00000376083.3_Silent_p.S195S|AGTPBP1_ENST00000491784.1_5'UTR|AGTPBP1_ENST00000432218.1_Silent_p.S33S|AGTPBP1_ENST00000376081.4_Silent_p.S195S			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	195					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						TTTTCCCTAAGGATACTGAAT	0.328000													9	85					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52495482	52495482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:52495482G>A	ENST00000216286.5	-	11	2487	c.2488C>T	c.(2488-2490)Cgg>Tgg	p.R830W	NID2_ENST00000541773.1_Missense_Mutation_p.R777W	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	830	EGF-like 3; calcium-binding (Potential).		R -> Q (in dbSNP:rs7144523).			basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TAACCACTCCGGCACTCACAC	0.443000													23	38					0	0	1	0	0
GPR15	2838	broad.mit.edu	37	3	98251249	98251249	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98251249C>T	ENST00000284311.3	+	1	507	c.372C>T	c.(370-372)ctC>ctT	p.L124L		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	124						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		TCCTCCTGCTCACTTGCATGA	0.512000													9	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061525	9061525	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9061525G>A	ENST00000397910.4	-	3	26124	c.25921C>T	c.(25921-25923)Ccc>Tcc	p.P8641S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8643	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTGAGGAGGGATGAATTTTC	0.428000													24	62					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28660122	28660122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28660122C>T	ENST00000280904.6	-	10	1903	c.1460G>A	c.(1459-1461)gGa>gAa	p.G487E	DSC2_ENST00000251081.6_Missense_Mutation_p.G487E	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	487	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GCTTGTTGTTCCCACTTCTGC	0.383000													46	97					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50666517	50666517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:50666517C>T	ENST00000371821.1	+	7	1140	c.825C>T	c.(823-825)ccC>ccT	p.P275P	ELAVL4_ENST00000371824.1_Intron|ELAVL4_ENST00000448907.2_Intron|ELAVL4_ENST00000371823.4_Silent_p.P270P|ELAVL4_ENST00000371819.1_Intron|ELAVL4_ENST00000371827.1_Intron|ELAVL4_ENST00000357083.4_Intron			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	270					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						CTGCTTGTCCCCCCAGGTTCT	0.522000													45	196					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41792152	41792152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41792152G>A	ENST00000396930.3	-	18	4129	c.3586C>T	c.(3586-3588)Cct>Tct	p.P1196S	KAT6A_ENST00000265713.2_Missense_Mutation_p.P1196S|KAT6A_ENST00000406337.1_Missense_Mutation_p.P1196S	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1196					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										CCAGCTTTAGGAATGGAAACG	0.483000													25	140					0	0	1	0	0
FAM124B	79843	broad.mit.edu	37	2	225265794	225265794	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:225265794C>T	ENST00000389874.3	-	1	917	c.692G>A	c.(691-693)tGg>tAg	p.W231*	FAM124B_ENST00000243806.2_Nonsense_Mutation_p.W231*|FAM124B_ENST00000409685.3_Nonsense_Mutation_p.W231*	NM_024785.2	NP_079061.2	Q9H5Z6	F124B_HUMAN	family with sequence similarity 124B	231							protein binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	16		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		CTGAGTCTGCCACCTGGTGCT	0.488000													23	75					0	0	1	0	0
PKN3	29941	broad.mit.edu	37	9	131476552	131476552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131476552C>T	ENST00000291906.4	+	11	1782	c.1389C>T	c.(1387-1389)ccC>ccT	p.P463P		NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3	463	Pro-rich.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						ACCTGCTGCCCCCCTGCAGCT	0.647000													48	124					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61939428	61939428	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61939428G>A	ENST00000422202.1	+	6	850	c.782G>A	c.(781-783)gGg>gAg	p.G261E	COL20A1_ENST00000326996.6_Missense_Mutation_p.G254E|COL20A1_ENST00000435874.1_Missense_Mutation_p.G261E|COL20A1_ENST00000358894.6_Missense_Mutation_p.G254E			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	254	VWFA.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					TACAAGGGGGGGAACACGTTC	0.627000													12	28					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25936266	25936266	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:25936266C>T	ENST00000398988.3	+	18	2236	c.1791C>T	c.(1789-1791)ctC>ctT	p.L597L	KSR1_ENST00000268763.6_Silent_p.L597L|KSR1_ENST00000319524.6_Silent_p.L734L|KSR1_ENST00000509603.2_Silent_p.L712L	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	732					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		ACAAAGATCTCAAATCTAAGA	0.532000													25	20					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44803639	44803639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44803639C>T	ENST00000372262.3	-	11	2393	c.1993G>A	c.(1993-1995)Gac>Aac	p.D665N	CDH22_ENST00000537909.1_Missense_Mutation_p.D665N	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	665					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				ATGACGTTGTCCCGCATGTCT	0.627000													15	46					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288793	107288793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107288793C>T	ENST00000277216.3	-	1	697	c.698G>A	c.(697-699)gGa>gAa	p.G233E		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						CTTGTGTCTTCCTGTGGCCGA	0.428000													55	117					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327717	52327717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52327717C>T	ENST00000339223.4	+	2	895	c.716C>T	c.(715-717)cCc>cTc	p.P239L	FPR3_ENST00000595991.1_Missense_Mutation_p.P239L	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	239					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TCCAGCCGTCCCTTACGTGTC	0.453000													19	41					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37709492	37709492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37709492C>T	ENST00000248901.6	+	13	1312	c.1125C>T	c.(1123-1125)acC>acT	p.T375T		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	375	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CCAGCATCACCCGTGTCCCCT	0.577000													24	76					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151376575	151376575	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151376575C>T	ENST00000370314.4	-	7	914	c.676G>A	c.(676-678)Gga>Aga	p.G226R	GABRA3_ENST00000370311.1_Missense_Mutation_p.G226R|GABRA3_ENST00000535043.1_Missense_Mutation_p.G226R	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	226					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTGTTCTTTCCGAGAGTCCAA	0.448000													55	35					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158900900	158900900	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:158900900C>T	ENST00000367097.3	+	7	2501	c.1144C>T	c.(1144-1146)Cag>Tag	p.Q382*	TULP4_ENST00000367094.2_Nonsense_Mutation_p.Q382*	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	382	SOCS box.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GCTGCTGTGCCAGCAGGCCAT	0.647000													22	31					0	0	1	0	0
SLAMF6	114836	broad.mit.edu	37	1	160458917	160458917	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160458917C>T	ENST00000368059.3	-	6	906	c.837G>A	c.(835-837)acG>acA	p.T279T	SLAMF6_ENST00000368055.1_Silent_p.T169T|SLAMF6_ENST00000368057.3_Silent_p.T280T	NM_001184714.1|NM_001184715.1|NM_001184716.1|NM_052931.4	NP_001171643.1|NP_001171644.1|NP_001171645.1|NP_443163.1	Q96DU3	SLAF6_HUMAN	SLAM family member 6	280						integral to membrane|plasma membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(4)	22	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			CAGTGTTGTTCGTTGGAGACA	0.443000													43	101					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31294509	31294509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:31294509G>A	ENST00000542188.1	-	27	4758	c.4445C>T	c.(4444-4446)tCc>tTc	p.S1482F	TRPM1_ENST00000256552.6_Missense_Mutation_p.S1465F|TRPM1_ENST00000397795.2_Missense_Mutation_p.S1443F|RP11-348B17.1_ENST00000561299.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1443					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TCTTCCCCGGGAATAGACGAA	0.453000													45	88					0	0	1	0	0
TMEM8C	389827	broad.mit.edu	37	9	136380695	136380695	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136380695G>A	ENST00000339996.3	-	4	535	c.434C>T	c.(433-435)cCa>cTa	p.P145L	TMEM8C_ENST00000413714.1_5'UTR	NM_001080483.2	NP_001073952.1	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	145						integral to membrane				NS(1)|autonomic_ganglia(1)|large_intestine(2)|lung(4)	8						GCTCTTGTCTGGGTACAGGCC	0.597000													30	48					0	0	1	0	0
SLC39A8	64116	broad.mit.edu	37	4	103188658	103188658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:103188658G>A	ENST00000424970.2	-	8	1537	c.1222C>T	c.(1222-1224)Ctg>Ttg	p.L408L	SLC39A8_ENST00000394833.2_Silent_p.L408L|SLC39A8_ENST00000356736.4_Silent_p.L408L	NM_001135147.1	NP_001128619.1	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter), member 8	408						integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity			large_intestine(1)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		ATATCTGCCAGAGAAATATAG	0.358000													12	52					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181745299	181745299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181745299C>T	ENST00000526775.1	+	37	5310	c.5145C>T	c.(5143-5145)tcC>tcT	p.S1715S	CACNA1E_ENST00000367567.4_Silent_p.S1341S|CACNA1E_ENST00000358338.5_Silent_p.S1666S|CACNA1E_ENST00000367570.1_Silent_p.S1734S|CACNA1E_ENST00000360108.3_Silent_p.S1715S|CACNA1E_ENST00000367573.2_Silent_p.S1734S|CACNA1E_ENST00000357570.5_Silent_p.S1685S	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1734					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GGGACTCCTCCATCCTGGGGC	0.607000													71	157					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531646	50531646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50531646G>A	ENST00000374144.3	+	3	1344	c.1056G>A	c.(1054-1056)agG>agA	p.R352R	C10orf71_ENST00000323868.4_Silent_p.R352R			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	352										endometrium(1)	1						GGGGGTGCAGGGATCCAGGAG	0.582000													16	32					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564418	176564418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176564418C>T	ENST00000367662.3	+	3	2842	c.1678C>T	c.(1678-1680)Cgc>Tgc	p.R560C	PAPPA2_ENST00000367661.3_Missense_Mutation_p.R560C	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	560	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGCCTTCAGCCGCTACAACAT	0.557000													14	63					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	53883852	53883852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:53883852G>A	ENST00000514921.1	+	1	139	c.26G>A	c.(25-27)aGa>aAa	p.R9K	MLIP_ENST00000370877.2_Missense_Mutation_p.R9K|MLIP_ENST00000509997.1_Missense_Mutation_p.R9K|MLIP_ENST00000274897.5_Missense_Mutation_p.R9K			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	9	Interaction with LMNA.					nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						CGTGAAAAAAGAAGCTTATTA	0.363000													15	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438476	179438476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179438476C>T	ENST00000589042.1	-	326	72607	c.72383G>A	c.(72382-72384)gGa>gAa	p.G24128E	TTN_ENST00000342992.6_Missense_Mutation_p.G21560E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G15063E|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G15255E|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G15188E|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G22487E|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22487	Fibronectin type-III 75.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCAAAGGTCCTTCAGGTGG	0.448000													29	94					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83456104	83456104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83456104C>T	ENST00000334574.8	-	2	220	c.39G>A	c.(37-39)agG>agA	p.R13R	FSD2_ENST00000541889.1_Silent_p.R13R			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	13										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						TGGGAGTAGACCTGTCCAGCC	0.468000													65	64					0	0	1	0	0
GALNT2	2590	broad.mit.edu	37	1	230338999	230338999	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230338999C>T	ENST00000366672.4	+	3	409	c.337C>T	c.(337-339)Cga>Tga	p.R113*	GALNT2_ENST00000543760.1_Nonsense_Mutation_p.R75*|GALNT2_ENST00000541865.1_Nonsense_Mutation_p.R23*	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	113					immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				TGATAAGCTTCGAATGGACAG	0.537000													42	97					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160811241	160811241	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160811241C>T	ENST00000368034.4	-	3	591	c.414G>A	c.(412-414)ggG>ggA	p.G138G	CD244_ENST00000322302.7_Intron|CD244_ENST00000368033.3_Silent_p.G143G|CD244_ENST00000368032.2_Silent_p.G138G	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	143	Ig-like 2.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCAGGATCTTCCCCTGCCCCT	0.507000													34	82					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94580218	94580218	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:94580218C>T	ENST00000258526.4	+	4	1657	c.1408C>T	c.(1408-1410)Cct>Tct	p.P470S		NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	470					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AGCCACAGACCCTCACTGCGG	0.443000													10	42					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52945956	52945956	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52945956C>T	ENST00000295213.4	+	9	1600	c.1226C>T	c.(1225-1227)cCt>cTt	p.P409L	SPATA18_ENST00000419395.2_Missense_Mutation_p.P377L	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	409					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCATTCCCTCCTGTCGTTGAC	0.438000													90	218					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527037	23527037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:23527037G>A	ENST00000296682.3	+	11	2022	c.1840G>A	c.(1840-1842)Ggg>Agg	p.G614R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	614					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.G614W(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CAGGGAGTGTGGGCGGGGCTT	0.622000										HNSCC(3;0.000094)			12	73					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86389422	86389422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:86389422C>T	ENST00000285379.5	+	6	811	c.581C>T	c.(580-582)cCa>cTa	p.P194L		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	194					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	TGGACCTACCCAGGCTCACTG	0.512000													32	240					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198713186	198713186	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:198713186C>T	ENST00000367376.2	+	26	2866	c.2695C>T	c.(2695-2697)Cag>Tag	p.Q899*	PTPRC_ENST00000594404.1_Nonsense_Mutation_p.Q738*|PTPRC_ENST00000442510.2_Nonsense_Mutation_p.Q901*|PTPRC_ENST00000352140.3_Nonsense_Mutation_p.Q851*|PTPRC_ENST00000348564.6_Nonsense_Mutation_p.Q740*	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	899	Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						ATTGTAGGCCCAGTACATCTT	0.328000													10	41					0	0	1	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48519169	48519169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48519169C>T	ENST00000339841.2	+	4	406	c.228C>T	c.(226-228)ttC>ttT	p.F76F	ELSPBP1_ENST00000597519.1_Intron	NM_022142.4	NP_071425.3	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1	76	Fibronectin type-II 2.				single fertilization	extracellular region				NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(6)	10		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		GCTGTATCTTCCCTTTCATCT	0.458000													19	49					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86702171	86702171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86702171G>A	ENST00000441037.2	+	4	359	c.264G>A	c.(262-264)atG>atA	p.M88I	AGBL1_ENST00000421325.2_Missense_Mutation_p.M88I	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	88					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TAGTCTCCATGGGAGCCATGC	0.443000													31	111					0	0	1	0	0
RIT2	6014	broad.mit.edu	37	18	40695469	40695469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:40695469C>T	ENST00000589109.1	-	1	187	c.16G>A	c.(16-18)Gaa>Aaa	p.E6K	RIT2_ENST00000282028.4_Missense_Mutation_p.E6K|RIT2_ENST00000590910.1_Missense_Mutation_p.E6K|RIT2_ENST00000326695.5_Missense_Mutation_p.E6K	NM_001272077.1	NP_001259006.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	6					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CAGCTGGCTTCATTTTCTACC	0.517000													23	88					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125599088	125599088	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125599088C>T	ENST00000316519.6	+	9	1187	c.981C>T	c.(979-981)ctC>ctT	p.L327L	AACS_ENST00000316543.10_5'UTR|AACS_ENST00000261686.6_Silent_p.L327L	NM_023928.3	NP_076417.2	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	327					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(4)|liver(1)|lung(16)|ovary(1)|stomach(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		GTGACATCCTCCTGTGCTACA	0.602000													8	31					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11343898	11343898	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11343898G>A	ENST00000294618.7	-	22	2710	c.2699C>T	c.(2698-2700)tCc>tTc	p.S900F	DOCK6_ENST00000319867.7_Missense_Mutation_p.S204F	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	900					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CAGGATGCGGGAAACCTCGTC	0.622000													10	21					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38952011	38952011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38952011G>A	ENST00000359357.3	+	85	12584	c.12330G>A	c.(12328-12330)atG>atA	p.M4110I	DNAH8_ENST00000441566.1_Missense_Mutation_p.M4074I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTCGGTACATGATCGGAGAAG	0.343000													16	85					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291424	33291424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:33291424G>A	ENST00000280979.4	+	13	4575	c.4405G>A	c.(4405-4407)Gat>Aat	p.D1469N	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1469					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TACATTTTATGATTACTCATA	0.373000													19	30					0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138418941	138418941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138418941G>A	ENST00000310018.2	-	16	1913	c.1631C>T	c.(1630-1632)tCg>tTg	p.S544L	ATP6V0A4_ENST00000393054.1_Missense_Mutation_p.S544L|ATP6V0A4_ENST00000353492.4_Missense_Mutation_p.S544L	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	544					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CAGGATCACCGACATCTTCAT	0.428000													31	68					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113803741	113803741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113803741G>A	ENST00000260191.2	+	6	879	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K	HTR3B_ENST00000537778.1_Missense_Mutation_p.E197K	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	208					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CAGTGAGTGGGAACTTCTATC	0.473000													7	57					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382199	152382199	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152382199G>A	ENST00000271835.3	-	3	1421	c.1359C>T	c.(1357-1359)ctC>ctT	p.L453L	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	453					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGTCCAGCCTGAGGATCACTG	0.572000													30	87					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77948989	77948989	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77948989C>T	ENST00000393684.3	-	5	776	c.385G>A	c.(385-387)Gac>Aac	p.D129N	ISM2_ENST00000429906.1_Missense_Mutation_p.D136N|ISM2_ENST00000412904.1_Missense_Mutation_p.D136N|ISM2_ENST00000493585.1_Intron|ISM2_ENST00000342219.4_Missense_Mutation_p.D217N			Q6H9L7	ISM2_HUMAN	isthmin 2	217						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						GCCTGGGGGTCCTCCACCACC	0.627000													47	101					0	0	1	0	0
GBP3	2635	broad.mit.edu	37	1	89481012	89481012	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:89481012G>A	ENST00000370481.4	-	3	496	c.276C>T	c.(274-276)acC>acT	p.T92T	GBP3_ENST00000475853.2_5'UTR	NM_018284.2	NP_060754.2	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	92						integral to membrane	GTP binding|GTPase activity			breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		GCAGGACTAAGGTGTGTTCTG	0.458000													48	131					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54343015	54343015	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:54343015T>C	ENST00000306888.2	-	8	1760	c.1509A>G	c.(1507-1509)gaA>gaG	p.E503E	FIP1L1_ENST00000507166.1_Intron|LNX1_ENST00000263925.7_Silent_p.E599E	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	599						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGCTGCAGTCTTCCTGGGGCT	0.537000													12	130					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41796986	41796986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41796986G>A	ENST00000263800.6	-	17	2201	c.2105C>T	c.(2104-2106)tCc>tTc	p.S702F	LTK_ENST00000355166.5_Missense_Mutation_p.S641F|LTK_ENST00000453182.2_Missense_Mutation_p.S572F|LTK_ENST00000561619.1_Missense_Mutation_p.S400F	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	702	Protein kinase.				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		ATCTGTCTTGGATGTGAAGAT	0.607000										TSP Lung(18;0.14)			20	56					0	0	1	0	0
NRG2	9542	broad.mit.edu	37	5	139232060	139232060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139232060G>A	ENST00000541337.1	-	6	1532	c.1303C>T	c.(1303-1305)Cct>Tct	p.P435S	NRG2_ENST00000340391.3_Missense_Mutation_p.P298S|NRG2_ENST00000361474.1_Missense_Mutation_p.P501S|NRG2_ENST00000545385.1_Missense_Mutation_p.P503S|NRG2_ENST00000394770.1_3'UTR|NRG2_ENST00000289409.4_Missense_Mutation_p.P495S|NRG2_ENST00000289422.7_Missense_Mutation_p.P509S|NRG2_ENST00000358522.3_Missense_Mutation_p.P503S|CTB-35F21.4_ENST00000504413.1_RNA	NM_001184935.1	NP_001171864.1	O14511	NRG2_HUMAN	neuregulin 2	501					embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	25			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGAGAAGGAGAACAGGAG	0.532000													11	87					0	0	1	0	0
EAPP	55837	broad.mit.edu	37	14	35005444	35005444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:35005444G>A	ENST00000250454.3	-	2	193	c.112C>T	c.(112-114)Cct>Tct	p.P38S		NM_018453.3	NP_060923.2	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	38					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	12	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		TTTTGGTCAGGAGTTCCATGT	0.318000													20	42					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103260388	103260388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:103260388G>A	ENST00000553106.1	-	5	967	c.495C>T	c.(493-495)gcC>gcT	p.A165A	PAH_ENST00000551988.1_Intron|PAH_ENST00000307000.2_Silent_p.A160A	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	165					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	GGTAGTTGTAGGCAATGTCAG	0.488000													11	83					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149481113	149481113	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149481113G>A	ENST00000378016.2	+	0	2595							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTCCTCTGGGGCTGCTGTGGG	0.642000													6	16					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39602432	39602432	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39602432G>A	ENST00000352251.3	-	5	1134	c.301C>T	c.(301-303)Cgt>Tgt	p.R101C	PROSER1_ENST00000350125.3_Missense_Mutation_p.R79C	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	101																	TCAATAGGACGAGAATTCTGT	0.338000													12	24					0	0	1	0	0
NDST3	9348	broad.mit.edu	37	4	119064785	119064785	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119064785G>A	ENST00000296499.5	+	6	1888	c.1485G>A	c.(1483-1485)gaG>gaA	p.E495E	NDST3_ENST00000433996.2_Silent_p.E414E	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	495	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						GTCCTAAAGAGCTGGATAAGA	0.403000													28	52					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206166306	206166306	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206166306G>A	ENST00000406610.2	+	18	2718	c.2511G>A	c.(2509-2511)acG>acA	p.T837T	PARD3B_ENST00000349953.3_Silent_p.T837T|PARD3B_ENST00000351153.1_Silent_p.T768T|PARD3B_ENST00000358768.2_Silent_p.T775T|PARD3B_ENST00000462231.1_Silent_p.T837T	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	837	Lys-rich.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TCAAAAAAACgaaagagaagg	0.433000													26	42					0	0	1	0	0
SENP8	123228	broad.mit.edu	37	15	72432138	72432138	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72432138C>T	ENST00000544411.1	+	3	661	c.174C>T	c.(172-174)gtC>gtT	p.V58V	SENP8_ENST00000542035.2_Silent_p.V58V|SENP8_ENST00000544171.1_Silent_p.V58V|SENP8_ENST00000340912.4_Silent_p.V58V	NM_001172109.1|NM_001172110.1	NP_001165580.1|NP_001165581.1	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	58	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			breast(1)|kidney(2)|lung(1)|ovary(1)|skin(1)	6						GCCCTGAAGTCACCCAGTTCA	0.463000													96	129					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043700	20043700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20043700G>A	ENST00000570682.1	-	2	719	c.419C>T	c.(418-420)tCa>tTa	p.S140L		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	140						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						GGCTGGGTATGAGACCGTGTG	0.507000													32	83					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44974301	44974301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:44974301G>A	ENST00000340446.4	-	1	2181	c.1890C>T	c.(1888-1890)gcC>gcT	p.A630A		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	630	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		CTTCAGCGGGGGCCTCCTCAG	0.642000													5	27					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587196	36587196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36587196C>T	ENST00000332987.1	-	7	1393	c.971G>A	c.(970-972)aGg>aAg	p.R324K	APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000352371.1_Missense_Mutation_p.R327K|APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000404685.3_3'UTR			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	328					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						AGCCCACTGCCTCAGCGACTC	0.537000													6	19					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158152041	158152041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158152041C>T	ENST00000368171.3	+	4	1047	c.548C>T	c.(547-549)aCc>aTc	p.T183I		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	183					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CTTAATGGCACCTGCCCCCAA	0.552000													52	211					0	0	1	0	0
GNRHR	2798	broad.mit.edu	37	4	68610308	68610308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68610308C>T	ENST00000420975.2	-	2	591	c.592G>A	c.(592-594)Ggt>Agt	p.G198S	RP11-453E17.1_ENST00000502758.1_RNA|RP11-453E17.1_ENST00000500538.2_RNA|GNRHR_ENST00000226413.4_Silent_p.R240R	NM_001012763.1	NP_001012781.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	0					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	GATGAAGGACCCGTGTCAGGG	0.413000													14	65					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74627479	74627479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74627479G>A	ENST00000268082.4	+	9	1090	c.1070G>A	c.(1069-1071)gGa>gAa	p.G357E	CCDC33_ENST00000321288.5_Intron|CCDC33_ENST00000558821.1_Missense_Mutation_p.G323E|CCDC33_ENST00000398814.3_Intron			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	0							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GGTGGAGCAGGAAGCCACCGC	0.592000													33	154					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10132227	10132227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:10132227C>T	ENST00000324907.9	+	11	1550	c.1414C>T	c.(1414-1416)Ctc>Ttc	p.L472F	GRHL1_ENST00000324883.5_Missense_Mutation_p.L283F|GRHL1_ENST00000405379.2_Missense_Mutation_p.L472F	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	472					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TCAGCCTGTCCTCTTCATTCC	0.483000													13	50					0	0	1	0	0
TMCO5A	145942	broad.mit.edu	37	15	38234401	38234401	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:38234401G>A	ENST00000558158.1	+	9	668	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	TMCO5A_ENST00000540944.1_Missense_Mutation_p.E172K|TMCO5A_ENST00000319669.4_Missense_Mutation_p.E172K|TMCO5A_ENST00000559502.1_Missense_Mutation_p.E172K			Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	172						integral to membrane				central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	15						GAAGTACCAGGAAACGTTGAA	0.368000													65	140					0	0	1	0	0
SECTM1	6398	broad.mit.edu	37	17	80285043	80285043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80285043G>A	ENST00000269389.3	-	2	424	c.74C>T	c.(73-75)tCc>tTc	p.S25F	SECTM1_ENST00000580437.1_Missense_Mutation_p.S25F	NM_003004.2	NP_002995.1	Q8WVN6	SCTM1_HUMAN	secreted and transmembrane 1	25					immune response|mesoderm development|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular space|Golgi apparatus|integral to membrane|plasma membrane	cytokine activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(1)	4	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			AGCACTCAAGGAGGCAGCCAA	0.667000													5	16					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47882633	47882633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47882633G>A	ENST00000289672.2	-	34	5422	c.5372C>T	c.(5371-5373)tCc>tTc	p.S1791F		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1791					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GCCCGGCAGGGAAGCTTCTTG	0.473000													7	43					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	96014663	96014663	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96014663C>T	ENST00000260766.3	+	11	4045	c.3411C>T	c.(3409-3411)atC>atT	p.I1137I	PLCE1_ENST00000371375.1_Silent_p.I829I|PLCE1_ENST00000371380.2_Silent_p.I1137I|PLCE1_ENST00000371385.3_Silent_p.I829I	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1137					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TGAATGCCATCGCTAACCCTC	0.522000													109	255					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160921009	160921009	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160921009C>T	ENST00000368029.3	-	4	322	c.265G>A	c.(265-267)Ggc>Agc	p.G89S		NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	89	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTCCAGCCGCCACCCCCAGAA	0.577000													23	61					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59373296	59373296	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:59373296C>T	ENST00000348370.4	+	8	2543	c.2110C>T	c.(2110-2112)Cct>Tct	p.P704S	RNF111_ENST00000434298.1_Missense_Mutation_p.P704S|RNF111_ENST00000557998.1_Missense_Mutation_p.P704S|RNF111_ENST00000559209.1_Missense_Mutation_p.P704S|RNF111_ENST00000561186.1_Missense_Mutation_p.P704S	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	704	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		AACATCTCATCCTGTGGCACC	0.507000													22	165					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402857	124402857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124402857C>T	ENST00000368909.3	+	53	7291	c.7185C>T	c.(7183-7185)gtC>gtT	p.V2395V	DMBT1_ENST00000330163.4_Silent_p.V1767V|DMBT1_ENST00000368955.3_Silent_p.V2385V|DMBT1_ENST00000359586.6_Silent_p.V1115V|DMBT1_ENST00000368956.2_Silent_p.V1767V|DMBT1_ENST00000344338.3_Silent_p.V2385V|DMBT1_ENST00000338354.3_Silent_p.V2395V	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2395					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding	p.V2395V(3)|p.V2524V(2)		breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AGGTGGACGTCGTCCTGGGTC	0.647000													9	48					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609371	84609371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84609371G>A	ENST00000344803.2	+	4	4033	c.3986G>A	c.(3985-3987)gGg>gAg	p.G1329E		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AAGACATCAGGGGAGGTGCTT	0.507000													4	23					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854106	12854106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12854106G>A	ENST00000332296.7	+	3	433	c.330G>A	c.(328-330)gaG>gaA	p.E110E		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	110										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATGTTGACGAGAATTTCTGGG	0.542000													129	598					0	0	1	0	0
CHGA	1113	broad.mit.edu	37	14	93390581	93390581	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93390581G>A	ENST00000216492.5	+	2	364	c.84G>A	c.(82-84)ggG>ggA	p.G28G	CHGA_ENST00000553866.1_Intron|CHGA_ENST00000334654.4_Silent_p.G28G	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	28					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		TGAATAAAGGGGATACCGAGG	0.562000													9	19					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799331	45799331	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45799331C>T	ENST00000553795.1	-	4	848	c.540G>A	c.(538-540)ctG>ctA	p.L180L	OR13A1_ENST00000374401.2_Silent_p.L180L|OR13A1_ENST00000536058.1_Silent_p.L180L	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						AGCGCAGCATCAGCCCCGTGT	0.597000													27	58					0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76715603	76715603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76715603G>A	ENST00000264917.5	+	19	2186	c.2141G>A	c.(2140-2142)cGa>cAa	p.R714Q	PDE8B_ENST00000340978.3_Missense_Mutation_p.R667Q|PDE8B_ENST00000346042.3_Missense_Mutation_p.R617Q|PDE8B_ENST00000505283.1_Missense_Mutation_p.R179Q|PDE8B_ENST00000333194.4_Missense_Mutation_p.R659Q|PDE8B_ENST00000342343.4_Missense_Mutation_p.R694Q	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	714	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		AACCATTATCGAACGCTGCGC	0.413000													28	66					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116857374	116857374	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116857374G>A	ENST00000374118.3	-	8	871	c.634C>T	c.(634-636)Cct>Tct	p.P212S	KIF12_ENST00000473174.1_5'UTR	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	345	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						AGAGTCTCAGGAAGGCACTGG	0.647000													10	47					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98155765	98155765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98155765C>T	ENST00000357947.3	-	12	1622	c.1397G>A	c.(1396-1398)gGa>gAa	p.G466E	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	466	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GTTCATGTCTCCCCCGCAGGT	0.537000											OREG0020398	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	79					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467432	74467432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74467432C>T	ENST00000249842.3	+	2	590	c.233C>T	c.(232-234)tCg>tTg	p.S78L	RP11-665J16.1_ENST00000561647.1_RNA|ISLR_ENST00000395118.1_Missense_Mutation_p.S78L	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	78					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						CTGCTGCAGTCGCTGTGGCTG	0.647000													9	91					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	10973801	10973801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:10973801C>T	ENST00000304623.8	-	22	3631	c.3442G>A	c.(3442-3444)Gag>Aag	p.E1148K	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Missense_Mutation_p.E715K|CTNND2_ENST00000511377.1_Missense_Mutation_p.E1057K|CTNND2_ENST00000503622.1_Missense_Mutation_p.E811K|CTNND2_ENST00000359640.2_Missense_Mutation_p.E1090K	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1148					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CTGCTGGGCTCCTGTGGGACT	0.537000													22	49					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10416277	10416277	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10416277G>A	ENST00000226207.5	-	10	905	c.811C>T	c.(811-813)Ctg>Ttg	p.L271L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	271	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GACTTCTCCAGAAGATCTGCA	0.383000													10	16					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85486685	85486685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85486685G>A	ENST00000394573.1	+	16	1793	c.1591G>A	c.(1591-1593)Gaa>Aaa	p.E531K	SLC28A1_ENST00000286749.3_Missense_Mutation_p.E531K|SLC28A1_ENST00000538177.1_Missense_Mutation_p.E365K|SLC28A1_ENST00000537624.1_Missense_Mutation_p.E531K|SLC28A1_ENST00000537216.1_Intron	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	531					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGTCAGAGCTGAAGTCCTCAC	0.537000													16	68					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17084762	17084762	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17084762G>A	ENST00000455405.2	-	0	254																											CTTTACTAGAGACCCCGCGCA	0.572000													8	34					0	0	1	0	0
CATSPER3	347732	broad.mit.edu	37	5	134343727	134343727	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134343727C>T	ENST00000282611.6	+	4	659	c.573C>T	c.(571-573)ttC>ttT	p.F191F		NM_178019.2	NP_821138.1	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	191					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGTACATCTTCGCTATCTTGG	0.557000													28	86					0	0	1	0	0
FMO5	2330	broad.mit.edu	37	1	146684103	146684103	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:146684103C>T	ENST00000254090.4	-	5	876	c.487_splice	c.e5-1	p.G163_splice	FMO5_ENST00000369272.3_Splice_Site_p.G163_splice|FMO5_ENST00000441068.2_Splice_Site_p.G163_splice|FMO5_ENST00000465173.1_5'UTR	NM_001461.2	NP_001452.2	P49326	FMO5_HUMAN	flavin containing monooxygenase 5	163						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	25	all_hematologic(923;0.0487)					CTTCTCAATTCCTGCAAGAGA	0.353000													10	113					0	0	1	0	0
PYROXD1	79912	broad.mit.edu	37	12	21598304	21598304	+	Silent	SNP	C	C	T	rs3759228		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21598304C>T	ENST00000240651.9	+	3	243	c.189C>T	c.(187-189)ttC>ttT	p.F63F	PYROXD1_ENST00000538582.1_5'UTR|PYROXD1_ENST00000545178.1_Silent_p.F63F	NM_024854.3	NP_079130.2	Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 1	63							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|soft_tissue(1)	18						TGGAAGAATTCGATGTTGAAG	0.284000													4	39					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38320157	38320157	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38320157C>T	ENST00000264645.7	+	7	1435	c.1209C>T	c.(1207-1209)tcC>tcT	p.S403S		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	403	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						AGAAGAAATCCTATTCCCGGG	0.567000													20	120					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839329	62839329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62839329G>A	ENST00000536311.1	+	7	1144	c.780G>A	c.(778-780)gaG>gaA	p.E260E	MYT1_ENST00000328439.1_Silent_p.E260E|MYT1_ENST00000360149.4_Intron			Q01538	MYT1_HUMAN	myelin transcription factor 1	260	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					ACgaagaggaggacgaggagg	0.592000													5	9					0	0	1	0	0
NOG	9241	broad.mit.edu	37	17	54672217	54672217	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54672217G>A	ENST00000332822.4	+	1	1158	c.633G>A	c.(631-633)ggG>ggA	p.G211G		NM_005450.4	NP_005441.1	Q13253	NOGG_HUMAN	noggin	211					BMP signaling pathway|cartilage development|cell differentiation in hindbrain|dorsal/ventral pattern formation|embryonic digit morphogenesis|embryonic skeletal joint morphogenesis|epithelial to mesenchymal transition|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|middle ear morphogenesis|negative regulation of astrocyte differentiation|negative regulation of BMP signaling pathway|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of cytokine activity|negative regulation of osteoblast differentiation|osteoblast differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|somatic stem cell maintenance|wound healing	extracellular space	cytokine binding|protein homodimerization activity			ovary(1)	1	Breast(9;5.24e-08)					AGCGGCGCGGGGGCCAGCGCT	0.672000													3	12					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9990017	9990017	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:9990017G>A	ENST00000256190.8	-	14	1608	c.1471C>T	c.(1471-1473)Ctt>Ttt	p.L491F		NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	491					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GGGAAAGGAAGAATATGAACT	0.413000													52	235					0	0	1	0	0
PDXK	8566	broad.mit.edu	37	21	45152423	45152423	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45152423C>T	ENST00000327574.4	+	2	515	c.165C>T	c.(163-165)ccC>ccT	p.P55P	PDXK_ENST00000398081.1_Intron|PDXK_ENST00000476313.1_Intron|PDXK_ENST00000468090.1_Intron|PDXK_ENST00000291565.4_Intron			O00764	PDXK_HUMAN	pyridoxal (pyridoxine, vitamin B6) kinase	114					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	TTTGCCAGCCCCAAAGGATTA	0.453000													44	124					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22893441	22893441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22893441C>T	ENST00000543184.1	-	3	954	c.92G>A	c.(91-93)gGg>gAg	p.G31E	PRAME_ENST00000402697.1_Missense_Mutation_p.G31E|PRAME_ENST00000406503.1_Missense_Mutation_p.G31E|PRAME_ENST00000539862.1_Missense_Mutation_p.G15E|PRAME_ENST00000405655.3_Missense_Mutation_p.G31E|PRAME_ENST00000424204.2_Missense_Mutation_p.G15E|PRAME_ENST00000485532.1_5'UTR|PRAME_ENST00000398743.2_Missense_Mutation_p.G31E|PRAME_ENST00000398741.1_Missense_Mutation_p.G31E	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	31					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		CAGGCTCTGCCCTGCCAGCTC	0.592000													33	198					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175063316	175063316	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175063316G>A	ENST00000239462.4	+	7	1628	c.1515G>A	c.(1513-1515)gaG>gaA	p.E505E		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	505	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGCCAGGAGAGGCATACAAGG	0.542000													15	44					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74714293	74714293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74714293C>T	ENST00000373032.3	-	1	243	c.151G>A	c.(151-153)Gat>Aat	p.D51N		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	51					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					AGAAAAGAATCGAAGTAGCTA	0.537000													71	179					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7401451	7401451	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7401451C>T	ENST00000322644.6	+	8	1656	c.1257C>T	c.(1255-1257)atC>atT	p.I419I	POLR2A_ENST00000572844.1_Silent_p.I419I	NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	419					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				CCAAGTACATCATCCGAGACA	0.537000													32	47					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77442628	77442628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77442628G>A	ENST00000359047.2	-	7	1144	c.907C>T	c.(907-909)Ccc>Tcc	p.P303S	TRPM6_ENST00000451710.3_Intron|TRPM6_ENST00000376864.4_Intron|TRPM6_ENST00000449912.2_Intron|TRPM6_ENST00000360774.1_Intron|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000483186.1_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	0					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GATGGTCAGGGAAGACCATGA	0.557000													11	19					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158548779	158548779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158548779C>T	ENST00000368150.1	-	1	910	c.911G>A	c.(910-912)aGc>aAc	p.S304N		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					ATTCCTCAGGCTGAATATGAT	0.413000													60	126					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827087	96827087	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96827087C>T	ENST00000371270.3	-	3	453	c.359G>A	c.(358-360)tGg>tAg	p.W120*	CYP2C8_ENST00000539050.1_Nonsense_Mutation_p.W34*|CYP2C8_ENST00000535898.1_Nonsense_Mutation_p.W18*	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	120					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GATCTCCTTCCATCTCTTTCC	0.488000													45	77					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469482	10469482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10469482G>A	ENST00000382483.3	-	4	2349	c.2126C>T	c.(2125-2127)tCg>tTg	p.S709L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	709					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTGGTGCTCGATGAGCTTCC	0.617000													15	37					0	0	1	0	0
LIAS	11019	broad.mit.edu	37	4	39469178	39469178	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39469178C>T	ENST00000261434.3	+	7	767	c.649C>T	c.(649-651)Cga>Tga	p.R217*	LIAS_ENST00000513731.1_Nonsense_Mutation_p.R87*|LIAS_ENST00000340169.2_Nonsense_Mutation_p.R217*|LIAS_ENST00000381846.1_Intron	NM_006859.2	NP_006850.2	O43766	LIAS_HUMAN	lipoic acid synthetase	217					inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)|ovary(2)	12					Lipoic Acid(DB00166)	TCCTGATTTTCGAGGTGATCT	0.393000													47	98					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19725294	19725294	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:19725294C>T	ENST00000284885.3	-	10	1130	c.1097G>A	c.(1096-1098)tGg>tAg	p.W366*		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	366	MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						AATCCTTTCCCATTCATTATC	0.348000													40	152					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35802909	35802909	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35802909G>A	ENST00000361922.4	+	10	1855	c.1705G>A	c.(1705-1707)Gag>Aag	p.E569K	MAG_ENST00000392213.3_Missense_Mutation_p.E569K|MAG_ENST00000593348.1_3'UTR|MAG_ENST00000537831.2_Missense_Mutation_p.E544K	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	569					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TGGGGCACCAGAGAAGTACGA	0.637000													3	19					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76382131	76382131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:76382131G>A	ENST00000357063.3	+	11	3128	c.1868G>A	c.(1867-1869)aGt>aAt	p.S623N	LMO7_ENST00000341547.4_Intron|LMO7_ENST00000377534.3_Missense_Mutation_p.S623N|LMO7_ENST00000321797.8_Missense_Mutation_p.S338N|LMO7_ENST00000465261.2_Missense_Mutation_p.S338N|LMO7_ENST00000526202.1_Intron			Q8WWI1	LMO7_HUMAN	LIM domain 7	623						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AAAGAAAAAAGTAATAGCTGT	0.443000													23	52					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56638911	56638911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56638911G>A	ENST00000267116.7	-	22	2589	c.2468C>T	c.(2467-2469)cCc>cTc	p.P823L		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	823							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						AGGAGTGAAGGGGTTTCCTTC	0.507000													10	157					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651583	84651583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84651583G>A	ENST00000286744.5	+	21	3427	c.3203G>A	c.(3202-3204)gGa>gAa	p.G1068E	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G1068E	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1068						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			AATTCTGCAGGAAGCACCAAC	0.428000													27	101					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21459852	21459852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21459852C>T	ENST00000307378.6	-	6	1126	c.406G>A	c.(406-408)Gga>Aga	p.G136R	SLCO1A2_ENST00000537524.1_Missense_Mutation_p.G4R|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.G4R|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.G134R|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.G136R	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	136					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						ATCTGGGTTCCATTTTCCATA	0.358000													11	54					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70954694	70954694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70954694G>A	ENST00000334414.6	-	17	4233	c.4189C>T	c.(4189-4191)Ctc>Ttc	p.L1397F	PTPRB_ENST00000550857.1_Missense_Mutation_p.L1089F|PTPRB_ENST00000451516.2_Missense_Mutation_p.L1089F|PTPRB_ENST00000551525.1_Missense_Mutation_p.L1396F|PTPRB_ENST00000550358.1_Missense_Mutation_p.L1309F|PTPRB_ENST00000538708.1_Missense_Mutation_p.L1089F|PTPRB_ENST00000261266.5_Missense_Mutation_p.L1179F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1179	Fibronectin type-III 16.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GACCCCCTGAGATGACTCACA	0.453000													51	88					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49433061	49433061	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49433061G>A	ENST00000299191.3	+	5	787	c.670G>A	c.(670-672)Gag>Aag	p.E224K		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	224										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						GTTATCCAAGGAGAACATTCG	0.438000													12	87					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280766	152280766	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152280766G>A	ENST00000368799.1	-	3	6631	c.6596C>T	c.(6595-6597)tCa>tTa	p.S2199L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2199	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCATCTCCTGATTGTTCCTT	0.542000									Ichthyosis				174	395					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632848	143632848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143632848G>A	ENST00000408955.2	+	1	590	c.523G>A	c.(523-525)Gat>Aat	p.D175N		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CAAGTTTATTGATCACATATC	0.498000													31	72					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108383284	108383284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:108383284C>T	ENST00000265843.4	-	6	3060	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K	EXPH5_ENST00000428840.1_Missense_Mutation_p.E908K|EXPH5_ENST00000443411.1_Missense_Mutation_p.E796K|EXPH5_ENST00000525344.1_Missense_Mutation_p.E977K	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	984					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTTAACTTTTCAATACAGGAT	0.378000													27	109					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198665886	198665886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:198665886C>T	ENST00000367376.2	+	4	311	c.140C>T	c.(139-141)cCc>cTc	p.P47L	PTPRC_ENST00000594404.1_Intron|PTPRC_ENST00000442510.2_Missense_Mutation_p.P49L|PTPRC_ENST00000352140.3_Missense_Mutation_p.P47L|PTPRC_ENST00000391970.3_Intron|PTPRC_ENST00000348564.6_Intron	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	47					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TCAAGTGACCCCTTACCTACT	0.418000													23	135					0	0	1	0	0
SERPINB5	5268	broad.mit.edu	37	18	61156597	61156597	+	Silent	SNP	G	G	A	rs141561710	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61156597G>A	ENST00000382771.4	+	4	616	c.324G>A	c.(322-324)acG>acA	p.T108T	SERPINB5_ENST00000489441.1_Silent_p.T108T	NM_002639.4	NP_002630.2	P36952	SPB5_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 5	108					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			kidney(3)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	12						TCAGCTCTACGAAGAGACCGT	0.353000													8	64					0	0	1	0	0
TRBV6-9	28598	broad.mit.edu	37	7	142104269	142104269	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142104269G>A	ENST00000390379.1	-	0	195																											ACTGAGTAATGAATGCGCCTC	0.517000													89	181					0	0	1	0	0
OR8D4	338662	broad.mit.edu	37	11	123777309	123777309	+	Silent	SNP	C	C	T	rs79929702		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123777309C>T	ENST00000321355.2	+	1	201	c.171C>T	c.(169-171)acC>acT	p.T57T		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		AACTTCATACCCCCATGTACT	0.398000													43	152					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10247785	10247785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10247785G>A	ENST00000340748.4	-	36	4652	c.4417C>T	c.(4417-4419)Cgt>Tgt	p.R1473C	DNMT1_ENST00000540357.1_Missense_Mutation_p.R1473C|DNMT1_ENST00000359526.4_Missense_Mutation_p.R1489C			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	1473	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CAGACCCCACGGAGGGCCCCA	0.647000													7	10					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98351054	98351054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98351054G>A	ENST00000264972.5	+	9	1176	c.961G>A	c.(961-963)Gac>Aac	p.D321N	ZAP70_ENST00000442208.1_Missense_Mutation_p.D195N|ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000451498.2_Missense_Mutation_p.D14N	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	321	Interdomain B.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						CCCCTACAGCGACCCAGAGGA	0.587000													26	76					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56139282	56139282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56139282C>T	ENST00000319441.4	+	7	1183	c.1019C>T	c.(1018-1020)tCa>tTa	p.S340L	PCK1_ENST00000535860.1_Missense_Mutation_p.S208L|PCK1_ENST00000543666.1_Missense_Mutation_p.S23L	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	340					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCTGGGACTTCAGTGAAGACC	0.507000													31	61					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99725409	99725409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99725409G>A	ENST00000393483.3	-	7	941	c.97C>T	c.(97-99)Cgt>Tgt	p.R33C	TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000539964.1_Missense_Mutation_p.R33C|TSGA10_ENST00000542655.1_Missense_Mutation_p.R33C|TSGA10_ENST00000410001.1_Missense_Mutation_p.R33C|TSGA10_ENST00000355053.4_Missense_Mutation_p.R33C	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	33					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						AGTTCTTCACGATCTCTTGTT	0.343000													8	41					0	0	1	0	0
SLC22A20	440044	broad.mit.edu	37	11	64981640	64981640	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64981640C>T	ENST00000525437.1	+	0	330							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						GCCCCAACTCCTCCATCCCGG	0.682000													3	2					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242054730	242054730	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242054730G>A	ENST00000403638.3	-	13	3262	c.3171C>T	c.(3169-3171)tcC>tcT	p.S1057S	PASK_ENST00000358649.4_Silent_p.S1057S|PASK_ENST00000539818.1_Silent_p.S841S|PASK_ENST00000405260.1_Silent_p.S1057S|PASK_ENST00000544142.1_Silent_p.S871S|PASK_ENST00000234040.4_Silent_p.S1057S	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	1057	Protein kinase.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCTCCACCCTGGATAGAATTG	0.423000													42	69					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43012707	43012707	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43012707G>A	ENST00000587309.1	-	3	414	c.391C>T	c.(391-393)Ctg>Ttg	p.L131L	KIF18B_ENST00000590129.1_Silent_p.L140L|KIF18B_ENST00000593135.1_Silent_p.L131L|KIF18B_ENST00000438933.2_Silent_p.L131L|KIF18B_ENST00000339151.4_Silent_p.L131L	NM_001264573.1	NP_001251503.1			kinesin family member 18B											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				ACGGTGGTCAGGTACATGATG	0.642000													15	28					0	0	1	0	0
RBM46	166863	broad.mit.edu	37	4	155719196	155719196	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155719196G>A	ENST00000510397.1	+	3	564	c.385G>A	c.(385-387)Ggg>Agg	p.G129R	RBM46_ENST00000514866.1_Missense_Mutation_p.G129R|RBM46_ENST00000281722.3_Missense_Mutation_p.G129R	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	129	RRM 1.						nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				AATTCGACCAGGGAAGTTTAT	0.328000													28	72					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121947613	121947613	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121947613G>A	ENST00000377069.4	-	11	1717	c.1311C>T	c.(1309-1311)ttC>ttT	p.F437F	KDM2B_ENST00000377071.4_Silent_p.F468F|KDM2B_ENST00000536437.1_Silent_p.F351F|KDM2B_ENST00000538046.2_Silent_p.F378F	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	468					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						TCCTTTTGAGGAATCGCAGGG	0.612000													13	71					0	0	1	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28282549	28282549	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28282549G>A	ENST00000373894.3	+	7	1152	c.961G>A	c.(961-963)Gcc>Acc	p.A321T	SMPDL3B_ENST00000549094.1_Missense_Mutation_p.A273T|RP11-460I13.2_ENST00000448015.1_RNA|SMPDL3B_ENST00000373888.4_Missense_Mutation_p.A321T	NM_014474.2	NP_055289.2	Q92485	ASM3B_HUMAN	sphingomyelin phosphodiesterase, acid-like 3B	321					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	16		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		CAACAATCCAGCCATCCGGGT	0.567000													14	55					0	0	1	0	0
CD300C	10871	broad.mit.edu	37	17	72540995	72540995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72540995G>A	ENST00000330793.1	-	2	513	c.153C>T	c.(151-153)acC>acT	p.T51T		NM_006678.3	NP_006669.1	Q08708	CLM6_HUMAN	CD300c molecule	51	Ig-like V-type.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						ATTTGTTGAGGGTCCTGTGTT	0.542000													40	71					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61511339	61511339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61511339C>T	ENST00000257215.5	+	20	2623	c.2507C>T	c.(2506-2508)tCg>tTg	p.S836L		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	836					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		TCCCTGAGCTCGCGCACTGAG	0.672000													99	255					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1457560	1457560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1457560C>T	ENST00000345913.4	+	6	668	c.577C>T	c.(577-579)Ccc>Tcc	p.P193S	TPO_ENST00000382198.1_Missense_Mutation_p.P193S|TPO_ENST00000349624.3_Missense_Mutation_p.P193S|TPO_ENST00000329066.4_Missense_Mutation_p.P193S|TPO_ENST00000497517.2_Intron|TPO_ENST00000382201.3_Missense_Mutation_p.P193S|TPO_ENST00000337415.3_Missense_Mutation_p.P193S|TPO_ENST00000346956.3_Missense_Mutation_p.P193S	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	193					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AGGCTGGAACCCCGGCTTCTT	0.612000													15	68					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157562	22157562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22157562C>T	ENST00000397126.4	-	4	422	c.274G>A	c.(274-276)Gaa>Aaa	p.E92K	ZNF208_ENST00000599916.1_Missense_Mutation_p.E92K|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAAGAATCTTCTATGCCCTGC	0.318000													19	41					0	0	1	0	0
SLC23A1	9963	broad.mit.edu	37	5	138716319	138716319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:138716319C>T	ENST00000353963.3	-	5	438	c.400G>A	c.(400-402)Gag>Aag	p.E134K	SLC23A1_ENST00000348729.3_Missense_Mutation_p.E134K|SLC23A1_ENST00000503919.1_5'UTR	NM_152685.3	NP_689898.2	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 1	134					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(5)|ovary(1)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	CCGTAGATCTCCTCTGGGGGT	0.567000													25	45					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36230381	36230381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36230381G>A	ENST00000303965.4	-	2	1217	c.728C>T	c.(727-729)tCc>tTc	p.S243F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	243					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AAAGAATGGGGATGGTGGTGA	0.393000													49	110					0	0	1	0	0
CRISP1	167	broad.mit.edu	37	6	49806191	49806191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49806191G>A	ENST00000335847.4	-	7	682	c.581C>T	c.(580-582)cCa>cTa	p.P194L	CRISP1_ENST00000329411.5_Intron|CRISP1_ENST00000355791.2_Missense_Mutation_p.P194L|CRISP1_ENST00000505118.1_Missense_Mutation_p.P194L|CRISP1_ENST00000536021.1_Intron|CRISP1_ENST00000507853.1_Intron	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	194					fusion of sperm to egg plasma membrane	extracellular space		p.P194L(1)		endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					GGCTTCACATGGGACGCCTGT	0.363000													9	130					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228461637	228461637	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228461637C>A	ENST00000570156.2	+	22	6503	c.6429C>A	c.(6427-6429)gcC>gcA	p.A2143A	OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000422127.1_Silent_p.A1768A|OBSCN_ENST00000359599.6_Silent_p.A615A|RP5-1139B12.2_ENST00000602517.1_RNA|OBSCN_ENST00000284548.11_Silent_p.A1768A|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1123	Ig-like 21.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ATGAGACAGCCAGCCAGGGGG	0.657000													4	12					0.00909568	0.00909849	1	1	0
TECTA	7007	broad.mit.edu	37	11	120998597	120998597	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120998597C>T	ENST00000392793.1	+	9	2182	c.1911C>T	c.(1909-1911)ttC>ttT	p.F637F	TECTA_ENST00000264037.2_Silent_p.F637F			O75443	TECTA_HUMAN	tectorin alpha	637	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACCAGGGCTTCGTCCTCAGCA	0.657000													23	70					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44687287	44687287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44687287C>T	ENST00000222673.5	+	4	488	c.446C>T	c.(445-447)cCc>cTc	p.P149L	OGDH_ENST00000443864.2_Missense_Mutation_p.P149L|OGDH_ENST00000439616.2_Intron|OGDH_ENST00000444676.1_Missense_Mutation_p.P149L|OGDH_ENST00000447398.1_Intron|OGDH_ENST00000449767.1_Intron|OGDH_ENST00000543843.1_Intron	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	149					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	CAGCTGGACCCCCTGGGGATT	0.522000													26	53					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56244007	56244007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56244007G>A	ENST00000332836.2	-	2	1217	c.1190C>T	c.(1189-1191)gCt>gTt	p.A397V		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	397	NACHT.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TGCAGCCAAAGCACACAGGCT	0.453000													56	127					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44102463	44102463	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44102463G>A	ENST00000259746.9	+	2	325	c.142G>A	c.(142-144)Gac>Aac	p.D48N	TMEM63B_ENST00000323267.6_Missense_Mutation_p.D48N			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	48						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			GCTGGCTCTCGACTTCATGTG	0.602000													27	65					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157804377	157804377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157804377C>T	ENST00000368174.4	-	4	634	c.538G>A	c.(538-540)Gga>Aga	p.G180R		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	180	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTCCCACATCCCAGCTGCCGG	0.587000													24	86					0	0	1	0	0
NXF3	56000	broad.mit.edu	37	X	102334726	102334726	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:102334726G>A	ENST00000395065.3	-	13	1226	c.1125C>T	c.(1123-1125)tcC>tcT	p.S375S	NXF3_ENST00000425644.1_Silent_p.S47S|NXF3_ENST00000497850.1_5'UTR	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	375	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						GAATGCTCAGGGAGAAGCAGG	0.547000													47	39					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190437675	190437675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:190437675G>A	ENST00000261024.2	-	4	710	c.284C>T	c.(283-285)tCg>tTg	p.S95L		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	95					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			TACCACCAGCGAGGTCTGGGC	0.413000													15	67					0	0	1	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118351283	118351283	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118351283G>A	ENST00000528052.1	+	3	121	c.49_splice	c.e3-1	p.G17_splice	PNLIPRP1_ENST00000534537.1_Splice_Site_p.G17_splice|PNLIPRP1_ENST00000442761.1_Splice_Site_p.G17_splice|PNLIPRP1_ENST00000358834.4_Splice_Site_p.G17_splice|PNLIPRP1_ENST00000480870.2_3'UTR			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	17					lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		TTCTCTGTAGGAAAAGAAGTT	0.537000													41	109					0	0	1	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60351455	60351455	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60351455C>T	ENST00000602932.1	-	2	236	c.206G>A	c.(205-207)gGg>gAg	p.G69E	TBC1D3P2_ENST00000581291.1_RNA																							CACCAACTACCCGCGACCTCT	0.542000													119	474					0	0	1	0	0
PDLIM1	9124	broad.mit.edu	37	10	97006991	97006991	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97006991G>A	ENST00000329399.6	-	5	774	c.666C>T	c.(664-666)atC>atT	p.I222I	PDLIM1_ENST00000477757.1_5'UTR	NM_020992.2	NP_066272.1	O00151	PDLI1_HUMAN	PDZ and LIM domain 1	222					response to oxidative stress	cytoplasm|cytoskeleton	zinc ion binding			endometrium(1)|large_intestine(5)|lung(1)|ovary(1)|skin(2)	10		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CAGACTCCAGGATTTCCTGCA	0.453000													49	94					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222696018	222696018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:222696018C>T	ENST00000343410.6	-	9	2158	c.2100G>A	c.(2098-2100)agG>agA	p.R700R	HHIPL2_ENST00000473144.1_5'UTR	NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	700					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		TCAGGCTCTTCCTCCTCTTGC	0.572000													110	298					0	0	1	0	0
ALPP	250	broad.mit.edu	37	2	233245010	233245010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233245010G>A	ENST00000392027.2	+	6	1041	c.772G>A	c.(772-774)Gaa>Aaa	p.E258K	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	258						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TCTGGTGCAGGAATGGCTGGC	0.647000													31	97					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18276413	18276413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:18276413G>A	ENST00000377369.2	+	7	1375	c.1102G>A	c.(1102-1104)Ggc>Agc	p.G368S	SLC39A12_ENST00000377374.4_Missense_Mutation_p.G368S|SLC39A12_ENST00000377371.3_Missense_Mutation_p.G368S|SLC39A12_ENST00000539911.1_Missense_Mutation_p.G234S	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	368					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						CTTAGAATACGGCTACAGCAC	0.522000													26	49					0	0	1	0	0
IGHG3	3502	broad.mit.edu	37	14	106237723	106237723	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106237723C>T	ENST00000390551.2	-	0	19																											GGGGGAAGACCGATGGGCCCT	0.662000													6	46					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94049587	94049587	+	Missense_Mutation	SNP	C	C	T	rs139199272		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94049587C>T	ENST00000297268.6	+	35	2593	c.2122C>T	c.(2122-2124)Cgg>Tgg	p.R708W		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	708			Missing (in OI2A).|R -> Q (in Marfan syndrome).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	tgctggtcctCGGGGAAGCCC	0.448000										HNSCC(75;0.22)			27	91					0	0	1	0	0
UBE2E2	7325	broad.mit.edu	37	3	23541152	23541152	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:23541152C>T	ENST00000396703.1	+	4	461	c.281C>T	c.(280-282)cCc>cTc	p.P94L	UBE2E2_ENST00000425792.1_Missense_Mutation_p.P94L	NM_152653.3	NP_689866.1	Q96LR5	UB2E2_HUMAN	ubiquitin-conjugating enzyme E2E 2	94					ISG15-protein conjugation|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination	nucleolus	ATP binding|ISG15 ligase activity|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(2)	10						ATATTGGGACCCCCAGGATCT	0.398000													16	73					0	0	1	0	0
GATA3	2625	broad.mit.edu	37	10	8115917	8115917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:8115917G>A	ENST00000379328.3	+	6	1834	c.1266G>A	c.(1264-1266)ccG>ccA	p.P422P	GATA3_ENST00000461472.1_3'UTR|GATA3_ENST00000346208.3_Silent_p.P421P	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	421					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding	p.P422P(1)		NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CGCCCACGCCGATGCACCCGC	0.647000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						28	71					0	0	1	0	0
C9orf131	138724	broad.mit.edu	37	9	35044528	35044528	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35044528A>G	ENST00000312292.5	+	2	1949	c.1902A>G	c.(1900-1902)gaA>gaG	p.E634E	C9orf131_ENST00000421362.2_Silent_p.E586E|C9orf131_ENST00000354479.5_Silent_p.E561E	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	634										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AGCAAAAAGAAAACTGTGTTC	0.498000													23	162					0	0	1	0	0
NRN1	51299	broad.mit.edu	37	6	6006945	6006945	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6006945A>C	ENST00000244766.2	-	1	255	c.38T>G	c.(37-39)aTc>aGc	p.I13S		NM_016588.2	NP_057672.1	Q9NPD7	NRN1_HUMAN	neuritin 1	13						anchored to membrane|plasma membrane				endometrium(2)|large_intestine(2)|lung(4)	8	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		CACCGCGAGGATCAGTGAAAT	0.577000													42	97					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13793685	13793685	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13793685C>T	ENST00000265104.4	-	49	8267	c.8163G>A	c.(8161-8163)aaG>aaA	p.K2721K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2721	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGAACTGCCTCTTGAGTCTTT	0.498000									Kartagener syndrome				50	123					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51362271	51362271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:51362271C>T	ENST00000522124.1	+	6	924	c.263C>T	c.(262-264)tCc>tTc	p.S88F	SNTG1_ENST00000517473.1_Missense_Mutation_p.S88F|SNTG1_ENST00000518864.1_Missense_Mutation_p.S88F|SNTG1_ENST00000276467.5_Missense_Mutation_p.S88F	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	88	PDZ.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCAAAAATCTCCAAGGAACAA	0.313000													11	32					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112042662	112042662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112042662G>A	ENST00000241356.4	-	2	1272	c.867C>T	c.(865-867)ttC>ttT	p.F289F	ADORA3_ENST00000369716.4_Intron|ADORA3_ENST00000369717.4_Intron	NM_000677.3	NP_000668.1	P33765	AA3R_HUMAN	adenosine A3 receptor	289					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	AGGTTTCCTTGAACTTCTTTA	0.443000													20	40					0	0	1	0	0
HSPA5	3309	broad.mit.edu	37	9	127998957	127998957	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127998957C>T	ENST00000324460.6	-	8	2082	c.1879G>A	c.(1879-1881)Gtt>Att	p.V627I		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	627					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	ATTGGTTGAACAATTTCTTCC	0.423000										Prostate(1;0.17)			24	85					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123725021	123725021	+	Missense_Mutation	SNP	G	G	A	rs138933092		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123725021G>A	ENST00000223642.1	-	36	4461	c.4432C>T	c.(4432-4434)Cgg>Tgg	p.R1478W		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1478					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity	p.R1478W(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCAAATATCCGGAATCGTACA	0.373000													9	136					0	0	1	0	0
PLA2G3	50487	broad.mit.edu	37	22	31535929	31535929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31535929C>T	ENST00000215885.3	-	1	664	c.412G>A	c.(412-414)Gga>Aga	p.G138R		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	138					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						CCAGGGACTCCACTCTGCCCT	0.617000													10	47					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142724037	142724037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142724037G>A	ENST00000350513.2	-	1	245	c.183C>T	c.(181-183)ttC>ttT	p.F61F		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					GGTGGCTGAGGAAGAAATACA	0.443000													36	105					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50671870	50671870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50671870G>A	ENST00000439308.2	-	3	1483	c.991C>T	c.(991-993)Ctc>Ttc	p.L331F	TUBGCP6_ENST00000248846.5_Missense_Mutation_p.L331F	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	331					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGCAGCTGGAGCTCCCCTTGG	0.647000													8	19					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133150166	133150166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133150166C>T	ENST00000388996.4	-	12	2086	c.1666G>A	c.(1666-1668)Gac>Aac	p.D556N	KCNQ3_ENST00000519445.1_Missense_Mutation_p.D556N|KCNQ3_ENST00000521134.1_Missense_Mutation_p.D436N	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	556					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GAAAGCATGTCGAGATGCCCG	0.453000													20	104					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32716075	32716075	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:32716075G>A	ENST00000357033.4	-	9	1078	c.872C>T	c.(871-873)tCc>tTc	p.S291F	DMD_ENST00000378677.2_Missense_Mutation_p.S287F|DMD_ENST00000288447.4_Missense_Mutation_p.S283F	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	291					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGGCTTAGGGGAAGAAGTTCT	0.512000													11	4					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71471960	71471960	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71471960G>A	ENST00000322937.6	+	13	960	c.857G>A	c.(856-858)aGg>aAg	p.R286K	AMBN_ENST00000449493.2_Missense_Mutation_p.R271K	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	286					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			GGAGGCATGAGGCCCGGCTTT	0.537000													23	70					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59373179	59373179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:59373179C>T	ENST00000348370.4	+	8	2426	c.1993C>T	c.(1993-1995)Ccg>Tcg	p.P665S	RNF111_ENST00000434298.1_Missense_Mutation_p.P665S|RNF111_ENST00000557998.1_Missense_Mutation_p.P665S|RNF111_ENST00000559209.1_Missense_Mutation_p.P665S|RNF111_ENST00000561186.1_Missense_Mutation_p.P665S	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	665	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		TTCTGCCTGCCCGCATTCTCA	0.438000													25	161					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	27066599	27066599	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:27066599C>T	ENST00000539517.2	-	1	361	c.44G>A	c.(43-45)gGg>gAg	p.G15E	NOVA1_ENST00000547619.1_Missense_Mutation_p.G15E|NOVA1_ENST00000267422.7_5'UTR|NOVA1_ENST00000344429.5_Missense_Mutation_p.G15E|NOVA1_ENST00000574031.1_Missense_Mutation_p.G15E|NOVA1_ENST00000465357.2_Missense_Mutation_p.G15E	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	15					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		TATGGGAACCCCAGTGTGGGT	0.612000													4	13					0	0	1	0	0
ATP13A2	23400	broad.mit.edu	37	1	17318747	17318747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17318747G>A	ENST00000452699.1	-	18	2170	c.1981C>T	c.(1981-1983)Ccc>Tcc	p.P661S	RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000341676.5_Missense_Mutation_p.P661S|ATP13A2_ENST00000326735.8_Missense_Mutation_p.P666S	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	666					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CCTGTCTCGGGGTTGCAGAGC	0.672000													16	25					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144621331	144621331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144621331G>A	ENST00000262577.5	-	2	237	c.206C>T	c.(205-207)tCg>tTg	p.S69L		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	69					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CTTGCGCCACGAAGGCCCATG	0.672000													32	99					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99800315	99800315	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:99800315G>A	ENST00000259470.5	-	2	260	c.11C>T	c.(10-12)tCg>tTg	p.S4L	CTSV_ENST00000538255.1_Missense_Mutation_p.S4L|CTSV_ENST00000479932.1_5'UTR	NM_001333.3	NP_001324.2			cathepsin V																		CAGGACGAGCGAAAGATTCAT	0.413000													23	64					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37451769	37451769	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37451769G>A	ENST00000374660.1	+	17	1926	c.1827G>A	c.(1825-1827)ttG>ttA	p.L609L	ANKRD30A_ENST00000602533.1_Silent_p.L609L|ANKRD30A_ENST00000361713.1_Silent_p.L609L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	665						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AACAAACATTGAGAGCAGGTA	0.328000													35	72					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153661465	153661465	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153661465C>T	ENST00000368680.3	+	16	2926	c.2454C>T	c.(2452-2454)tcC>tcT	p.S818S		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	818					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	ACCTGCTGTCCCGCATGGAGC	0.632000													39	154					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15290645	15290645	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15290645C>T	ENST00000378116.4	-	5	753	c.747G>A	c.(745-747)caG>caA	p.Q249Q	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	249						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TACCCAGCTTCTGGTCAAACC	0.557000													27	72					0	0	1	0	0
AFP	174	broad.mit.edu	37	4	74308080	74308080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:74308080C>T	ENST00000395792.2	+	5	650	c.550C>T	c.(550-552)Cgc>Tgc	p.R184C	AFP_ENST00000226359.2_Missense_Mutation_p.R184C	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	184	Albumin 1.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTGGGCTGCTCGCTATGACAA	0.373000									Alpha-Fetoprotein, Hereditary Persistence of				13	63					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166785697	166785697	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166785697G>A	ENST00000243344.7	-	11	1471	c.1334C>T	c.(1333-1335)cCt>cTt	p.P445L		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	445						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						CAAGAAATCAGGATTTAGCTT	0.343000													18	49					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143633044	143633044	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143633044C>A	ENST00000408955.2	+	1	786	c.719C>A	c.(718-720)aCg>aAg	p.T240K		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					GCCTTCCACACGTGTGCCTCT	0.522000													21	86					7.45023e-12	7.48411e-12	1	1	0
FBXO15	201456	broad.mit.edu	37	18	71796789	71796789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:71796789C>T	ENST00000269500.5	-	5	743	c.408G>A	c.(406-408)atG>atA	p.M136I	FBXO15_ENST00000419743.2_Missense_Mutation_p.M212I	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	136										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		CAACATGCTCCATGATATATT	0.338000													13	46					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27185547	27185547	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27185547C>T	ENST00000380036.4	+	9	1689	c.1247C>T	c.(1246-1248)cCc>cTc	p.P416L	TEK_ENST00000519097.1_Missense_Mutation_p.P269L|TEK_ENST00000406359.4_Missense_Mutation_p.P373L	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	416	Ig-like C2-type 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CGGATCCTCCCCCCTGACTCA	0.423000													36	140					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50741774	50741774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50741774G>A	ENST00000300589.2	+	3	654	c.549G>A	c.(547-549)agG>agA	p.R183R	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	183	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				AGGCAAGAAGGCTGCTTGATC	0.478000													37	84					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6522131	6522131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6522131G>A	ENST00000377782.3	-	9	942	c.875C>T	c.(874-876)cCt>cTt	p.P292L	TNFRSF25_ENST00000348333.3_Missense_Mutation_p.P238L|TNFRSF25_ENST00000356876.3_Missense_Mutation_p.P283L|TNFRSF25_ENST00000351748.3_Missense_Mutation_p.P100L|TNFRSF25_ENST00000351959.5_Missense_Mutation_p.P246L	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	283					apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GGGGTAGCCAGGGGTCCAGCT	0.617000													22	78					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134617988	134617988	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:134617988C>T	ENST00000361388.2	+	5	934	c.468C>T	c.(466-468)cgC>cgT	p.R156R	CALD1_ENST00000417172.1_Silent_p.R156R|CALD1_ENST00000495522.1_Silent_p.R150R|CALD1_ENST00000361901.2_Silent_p.R156R|CALD1_ENST00000361675.2_Silent_p.R156R|CALD1_ENST00000393118.2_Silent_p.R150R|CALD1_ENST00000422748.1_Silent_p.R156R|CALD1_ENST00000543443.1_Silent_p.R161R|CALD1_ENST00000424922.1_Silent_p.R150R	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	369	Myosin and calmodulin-binding (By similarity).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						GTGAAAGTCGCCAAGAAAGAT	0.408000													9	20					0	0	1	0	0
C4orf26	152816	broad.mit.edu	37	4	76489530	76489530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76489530C>T	ENST00000311623.4	+	2	309	c.274C>T	c.(274-276)Cct>Tct	p.P92S	C4orf26_ENST00000435974.2_Silent_p.S106S	NM_001257072.1|NM_178497.3	NP_001244001.1|NP_848592.2	Q17RF5	CD026_HUMAN	chromosome 4 open reading frame 26	92						extracellular region				kidney(1)|large_intestine(4)|stomach(1)	6			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ACCTTTCGTCCCTTCAAGGTG	0.478000													66	178					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73477952	73477952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:73477952C>T	ENST00000377110.2	-	3	577	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	TRPM3_ENST00000357533.2_Missense_Mutation_p.E114K|TRPM3_ENST00000377111.2_Missense_Mutation_p.E112K|TRPM3_ENST00000377101.1_5'UTR|TRPM3_ENST00000360823.2_5'UTR|TRPM3_ENST00000361823.5_5'UTR|TRPM3_ENST00000377106.1_5'UTR|TRPM3_ENST00000437699.3_5'UTR|TRPM3_ENST00000423814.3_Missense_Mutation_p.E114K|TRPM3_ENST00000377105.1_5'UTR|TRPM3_ENST00000396283.1_5'UTR|TRPM3_ENST00000377097.3_5'UTR	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	112						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						AGGCGACTTTCATTTTTCTCA	0.488000													30	104					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28714584	28714584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28714584G>A	ENST00000257197.3	-	12	2088	c.1827C>T	c.(1825-1827)ttC>ttT	p.F609F	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Silent_p.F609F	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	609	Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TATCCAGAAAGAATTGAAAAG	0.353000													5	26					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88761493	88761493	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88761493C>T	ENST00000444431.1	+	0	2623				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										ACAATAATATCGTGAGTACAA	0.393000													45	103					0	0	1	0	0
C20orf24	55969	broad.mit.edu	37	20	35240525	35240525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35240525C>T	ENST00000342422.3	+	3	461	c.331C>T	c.(331-333)Cgt>Tgt	p.R111C	C20orf24_ENST00000373852.5_3'UTR|C20orf24_ENST00000344795.3_3'UTR|TGIF2-C20orf24_ENST00000558530.1_3'UTR	NM_199483.2	NP_955777.1			chromosome 20 open reading frame 24											breast(1)|kidney(1)|lung(2)	4	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GGAACTTGATCGTTGGGGAAC	0.512000													45	441					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17088210	17088210	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17088210G>A	ENST00000443236.1	-	15	1898	c.1867C>T	c.(1867-1869)Cag>Tag	p.Q623*	CPAMD8_ENST00000388925.4_Intron	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	576						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						ACTGCAAACTGAAGGCTGTCG	0.602000													28	72					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35974080	35974080	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:35974080G>A	ENST00000297866.5	+	8	1243	c.1177G>A	c.(1177-1179)Gaa>Aaa	p.E393K		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	393										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TTTTACAGGTGAACGATTTCA	0.348000													29	38					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7637888	7637888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7637888C>T	ENST00000572933.1	+	7	2300	c.840C>T	c.(838-840)ttC>ttT	p.F280F	DNAH2_ENST00000389173.2_Silent_p.F280F|DNAH2_ENST00000082259.3_Silent_p.F280F|DNAH2_ENST00000570791.1_Silent_p.F280F			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	280	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGATTGAGTTCTGGCGCAACC	0.537000													27	21					0	0	1	0	0
IL36G	56300	broad.mit.edu	37	2	113736882	113736882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113736882G>A	ENST00000259205.4	+	3	209	c.140G>A	c.(139-141)cGa>cAa	p.R47Q	IL36G_ENST00000376489.2_Intron	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	47					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						GCAGTTCCACGAAGTGACAGT	0.493000													11	45					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75227339	75227339	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:75227339G>A	ENST00000342232.4	-	2	936	c.896C>T	c.(895-897)tCc>tTc	p.S299F		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	299					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CATGCCATTGGAGCGCTCGCT	0.537000													26	159					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66638892	66638892	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66638892G>A	ENST00000393960.1	-	6	662	c.381C>T	c.(379-381)ttC>ttT	p.F127F	PC_ENST00000393958.2_Silent_p.F127F|PC_ENST00000355677.3_Silent_p.F127F|PC_ENST00000393955.2_Silent_p.F127F|PC_ENST00000524491.1_Silent_p.F87F	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	127	Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity	p.F127F(1)		cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AGGCCTGGGCGAAGTCCGCTC	0.632000													23	192					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83182733	83182733	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:83182733C>T	ENST00000398309.2	-	19	2537	c.2067G>A	c.(2065-2067)atG>atA	p.M689I	DLG2_ENST00000376106.3_Missense_Mutation_p.M153I|DLG2_ENST00000524982.1_Missense_Mutation_p.M685I|DLG2_ENST00000532653.1_Missense_Mutation_p.M671I|DLG2_ENST00000330014.6_Missense_Mutation_p.M610I|DLG2_ENST00000543673.1_Missense_Mutation_p.M794I|DLG2_ENST00000376104.2_Missense_Mutation_p.M794I|DLG2_ENST00000280241.8_Missense_Mutation_p.M728I|DLG2_ENST00000531015.1_Missense_Mutation_p.M656I|DLG2_ENST00000537455.1_Missense_Mutation_p.M439I|DLG2_ENST00000418306.2_Missense_Mutation_p.M568I|DLG2_ENST00000426717.2_Missense_Mutation_p.M153I|DLG2_ENST00000404783.3_Missense_Mutation_p.M167I	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	689	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCCGATCCTTCATGGGCCCCA	0.433000													23	34					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25272862	25272862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25272862G>A	ENST00000218548.6	+	12	1930	c.1597G>A	c.(1597-1599)Gag>Aag	p.E533K	ATP12A_ENST00000381946.3_Missense_Mutation_p.E527K	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	527					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGGGGCCCCTGAGCGCATCCT	0.562000													34	75					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232556	21232556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21232556C>T	ENST00000233242.1	-	26	7311	c.7184G>A	c.(7183-7185)gGa>gAa	p.G2395E		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2395					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATCAATAAATCCAACCAATTT	0.313000													8	25					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62543093	62543093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:62543093G>A	ENST00000383710.4	-	10	2089	c.1740C>T	c.(1738-1740)acC>acT	p.T580T	CADPS_ENST00000357948.3_Silent_p.T580T|CADPS_ENST00000283269.9_Silent_p.T580T	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	580	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GCTGGGGGTCGGTGTAATCCA	0.517000													29	133					0	0	1	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73315777	73315777	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73315777G>A	ENST00000258098.6	-	3	1209	c.969C>T	c.(967-969)gaC>gaT	p.D323D	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	323					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						GGCCCTGAAGGTCCAGAAGGG	0.622000													11	25					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886857	23886857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23886857G>A	ENST00000355349.3	-	31	4370	c.4208C>T	c.(4207-4209)gCc>gTc	p.A1403V		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1403					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGCCTCCACGGCCTCCTCAGC	0.607000													33	50					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7170372	7170372	+	Splice_Site	SNP	G	G	A	rs112283405		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7170372G>A	ENST00000406697.1	+	7	1019		c.e7+1		C1S_ENST00000328916.3_Splice_Site|C1S_ENST00000402681.3_Splice_Site|C1S_ENST00000360817.5_Splice_Site			P09871	C1S_HUMAN	complement component 1, s subcomponent						complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GTTGCCACAGGTAAGGCTCAC	0.423000													23	59					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169791926	169791926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169791926C>T	ENST00000263817.6	-	23	2948	c.2824G>A	c.(2824-2826)Gaa>Aaa	p.E942K		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	942	ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTGAGGGCTTCATTTGTAATC	0.448000													61	187					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13363724	13363724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13363724G>A	ENST00000254508.5	-	35	4966	c.4884C>T	c.(4882-4884)ttC>ttT	p.F1628F		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1628					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GCTCCACGGTGAACACATCTT	0.537000													44	100					0	0	1	0	0
EWSR1	2130	broad.mit.edu	37	22	29695762	29695762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29695762C>T	ENST00000397938.2	+	16	2171	c.1852C>T	c.(1852-1854)Cct>Tct	p.P618S	EWSR1_ENST00000414183.2_Missense_Mutation_p.P623S|EWSR1_ENST00000332035.6_Missense_Mutation_p.P562S|EWSR1_ENST00000331029.7_Missense_Mutation_p.P580S|EWSR1_ENST00000406548.1_Missense_Mutation_p.P617S|EWSR1_ENST00000332050.6_Missense_Mutation_p.P545S	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	618	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						ACGAGGTGGCCCTGGGGGGCC	0.597000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								7	8					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41135376	41135376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41135376C>T	ENST00000308370.7	+	34	4793	c.4793C>T	c.(4792-4794)tCc>tTc	p.S1598F	LTBP4_ENST00000243562.9_3'UTR|LTBP4_ENST00000204005.9_Missense_Mutation_p.S1561F|LTBP4_ENST00000545697.1_3'UTR|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000396819.3_Missense_Mutation_p.S1531F	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1599	EGF-like 16.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACGGATGGCTCCTTCCGCTGC	0.701000													23	45					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169826714	169826714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169826714G>A	ENST00000263817.6	-	15	1774	c.1650C>T	c.(1648-1650)acC>acT	p.T550T		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	550	ABC transporter 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTCCAACAAGGGTGTCAAATT	0.463000													6	24					0	0	1	0	0
ARRDC4	91947	broad.mit.edu	37	15	98513881	98513881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:98513881C>T	ENST00000268042.6	+	7	1272	c.1108C>T	c.(1108-1110)Cct>Tct	p.P370S	ARRDC4_ENST00000538249.1_Missense_Mutation_p.P283S	NM_183376.2	NP_899232.2	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	370					signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|skin(3)	16	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			TCCTCCTTACCCTCAACCCCC	0.438000													70	69					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181546989	181546989	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181546989C>T	ENST00000526775.1	+	4	765	c.600C>T	c.(598-600)ctC>ctT	p.L200L	CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000358338.5_Silent_p.L151L|CACNA1E_ENST00000367570.1_Silent_p.L200L|CACNA1E_ENST00000360108.3_Silent_p.L200L|CACNA1E_ENST00000367573.2_Silent_p.L200L|CACNA1E_ENST00000357570.5_Silent_p.L151L	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	200					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTTGAAGCTCGTGTCAGGGA	0.537000													8	10					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60476093	60476093	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60476093G>A	ENST00000371201.3	-	9	1270	c.1163C>T	c.(1162-1164)tCt>tTt	p.S388F	C1orf87_ENST00000450089.2_Missense_Mutation_p.S159F	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	388							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CAAATCAGAAGAAGCTCTGGT	0.388000													32	72					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003955	34003955	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34003955G>A	ENST00000374181.3	-	8	2101	c.1932C>T	c.(1930-1932)atC>atT	p.I644I	GRM4_ENST00000535756.1_Silent_p.I511I|GRM4_ENST00000374177.3_Silent_p.I528I|GRM4_ENST00000538487.1_Silent_p.I644I|GRM4_ENST00000545715.1_Silent_p.I336I|GRM4_ENST00000455714.2_Silent_p.I504I|GRM4_ENST00000544773.1_Silent_p.I475I	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	644					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CGGGCTCAGCGATCATGAGGA	0.602000													20	38					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138657008	138657008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138657008C>T	ENST00000298480.5	+	12	1241	c.1167C>T	c.(1165-1167)ttC>ttT	p.F389F	KCNT1_ENST00000487664.1_Silent_p.F344F|KCNT1_ENST00000491806.2_Silent_p.F356F|KCNT1_ENST00000371757.2_Silent_p.F389F|KCNT1_ENST00000490355.2_Silent_p.F370F|KCNT1_ENST00000263604.3_Silent_p.F370F|KCNT1_ENST00000488444.2_Silent_p.F370F|KCNT1_ENST00000486577.2_Silent_p.F350F			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	389						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TCATGGACTTCCTGAACGAGT	0.647000													45	85					0	0	1	0	0
GNLY	10578	broad.mit.edu	37	2	85922478	85922478	+	Missense_Mutation	SNP	G	G	A	rs149497301		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:85922478G>A	ENST00000409696.3	+	3	325	c.43G>A	c.(43-45)Gac>Aac	p.D15N	GNLY_ENST00000533041.1_3'UTR|GNLY_ENST00000524600.1_Missense_Mutation_p.D57N|GNLY_ENST00000263863.4_Missense_Mutation_p.D30N	NM_012483.2	NP_036615.2	P22749	GNLY_HUMAN	granulysin	30					cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				endometrium(4)|kidney(10)|large_intestine(1)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	19						TGAGTACTACGACCTGGCAAG	0.622000													16	30					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51287543	51287543	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:51287543G>A	ENST00000395542.2	-	2	324	c.140C>T	c.(139-141)tCg>tTg	p.S47L	COBL_ENST00000395540.2_Missense_Mutation_p.S47L|COBL_ENST00000441453.1_Missense_Mutation_p.S47L|COBL_ENST00000265136.7_Missense_Mutation_p.S47L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	47										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GTTCTGCTGCGACCCGAGGGC	0.627000													26	69					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043912	20043912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20043912G>A	ENST00000570682.1	-	2	507	c.207C>T	c.(205-207)ctC>ctT	p.L69L		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	69						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						CGGCAGCAGCGAGTGCCAAGA	0.473000													17	33					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89391179	89391179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89391179G>A	ENST00000439576.2	+	9	2016	c.1642G>A	c.(1642-1644)Gac>Aac	p.D548N	ACAN_ENST00000558207.1_Missense_Mutation_p.D548N|ACAN_ENST00000559004.1_Missense_Mutation_p.D548N|ACAN_ENST00000561243.1_Missense_Mutation_p.D548N|ACAN_ENST00000352105.7_Missense_Mutation_p.D548N	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	548					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			ATGCGTGGGTGACAAGGACAG	0.587000													35	110					0	0	1	0	0
WDR93	56964	broad.mit.edu	37	15	90255328	90255328	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90255328C>T	ENST00000268130.7	+	5	734	c.633C>T	c.(631-633)ctC>ctT	p.L211L	WDR93_ENST00000560294.1_Silent_p.L211L	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	211					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CAGCCTTCCTCCTACAAGGCA	0.388000													22	43					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31434773	31434773	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31434773C>T	ENST00000389202.2	+	25	3009	c.2960C>T	c.(2959-2961)cCa>cTa	p.P987L		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	987					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						ATGGAGGCCCCATCTCAGGTA	0.542000													20	62					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48626319	48626319	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48626319C>T	ENST00000006658.6	+	5	630	c.510C>T	c.(508-510)ttC>ttT	p.F170F	SPATA20_ENST00000511937.1_3'UTR|SPATA20_ENST00000393244.3_Silent_p.F110F|SPATA20_ENST00000356488.4_Silent_p.F154F	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	154					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			ACATGACGTTCGTGCAGGTGA	0.627000													12	41					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139396	90139396	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90139396C>T	ENST00000492446.1	+	0	194																											AGCTGGTTAGCCTGGTATCAG	0.527000													55	164					0	0	1	0	0
IGHV3-53	28420	broad.mit.edu	37	14	107048774	107048774	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107048774C>T	ENST00000390627.2	-	0	466																											ATCGGCCCTTCACGGAGTCTG	0.537000													61	412					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139263219	139263219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:139263219C>T	ENST00000395297.1	-	6	577	c.407G>A	c.(406-408)cGa>cAa	p.R136Q		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	136										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCAAGCGTTCGGCTGCTGAC	0.592000										HNSCC(54;0.14)			47	111					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1086331	1086331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1086331G>A	ENST00000441003.2	+	23	3067	c.3040G>A	c.(3040-3042)Gag>Aag	p.E1014K	MUC2_ENST00000359061.5_Missense_Mutation_p.E1014K	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1014	VWFD 3.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GGTGAGCAGCGAGCTGGACTT	0.647000													11	15					0	0	1	0	0
ZNF579	163033	broad.mit.edu	37	19	56090169	56090169	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56090169G>A	ENST00000325421.4	-	2	865	c.837C>T	c.(835-837)ttC>ttT	p.F279F		NM_152600.2	NP_689813.2	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		AGGGCCTGGCGAAGGCCTTGA	0.721000													10	27					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802809	185802809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185802809G>A	ENST00000302277.6	+	4	3280	c.2686G>A	c.(2686-2688)Gag>Aag	p.E896K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	896						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGGTGAAACTGAGCATTTAGA	0.403000													28	95					0	0	1	0	0
GSR	2936	broad.mit.edu	37	8	30538495	30538495	+	Missense_Mutation	SNP	G	G	A	rs3180947		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30538495G>A	ENST00000221130.5	-	12	1435	c.1345C>T	c.(1345-1347)Ccg>Tcg	p.P449S	GSR_ENST00000546342.1_Missense_Mutation_p.P420S|GSR_ENST00000537535.1_Missense_Mutation_p.P367S|GSR_ENST00000414019.1_Missense_Mutation_p.P406S|GSR_ENST00000541648.1_Missense_Mutation_p.P396S	NM_000637.3|NM_001195102.1|NM_001195103.1	NP_000628.2|NP_001182031.1|NP_001182032.1	P00390	GSHR_HUMAN	glutathione reductase	449					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	23				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TGATACATCGGGGTAAAGCTC	0.338000													14	180					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14749142	14749142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14749142G>A	ENST00000253673.5	-	11	1359	c.1259C>T	c.(1258-1260)tCc>tTc	p.S420F	EMR3_ENST00000443157.2_Missense_Mutation_p.S294F|EMR3_ENST00000599900.1_Missense_Mutation_p.S205F|EMR3_ENST00000344373.4_Missense_Mutation_p.S368F	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	420					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						GGCGATGATGGAGCACAGCAC	0.587000													8	36					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767539	57767539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57767539C>T	ENST00000371030.2	+	1	1465	c.1465C>T	c.(1465-1467)Ccc>Tcc	p.P489S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	489						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CCACTCCGTCCCCACTCAGCT	0.701000													19	58					0	0	1	0	0
H2BFWT	158983	broad.mit.edu	37	X	103268164	103268164	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:103268164C>T	ENST00000217926.5	-	1	95	c.69G>A	c.(67-69)atG>atA	p.M23I		NM_001002916.3	NP_001002916.2	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	23					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			breast(2)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	16						AGGCAGTGGCCATTAGATGGC	0.617000													13	13					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17675575	17675575	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17675575G>A	ENST00000262077.2	-	4	607	c.608C>T	c.(607-609)tCa>tTa	p.S203L	NUP153_ENST00000537253.1_Missense_Mutation_p.S203L	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	203					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			AGGTGGCAATGAAGTGTTCTT	0.368000													30	56					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179563498	179563498	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179563498G>A	ENST00000393371.2	-	3	614	c.318C>T	c.(316-318)ttC>ttT	p.F106F	RASGEF1C_ENST00000522500.1_5'UTR|RASGEF1C_ENST00000361132.4_Silent_p.F106F			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	106	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTTGGGGCCGAACTTCCGGA	0.682000													4	5					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179399221	179399221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179399221C>T	ENST00000589042.1	-	358	102345	c.102121G>A	c.(102121-102123)Gag>Aag	p.E34041K	TTN_ENST00000342992.6_Missense_Mutation_p.E31473K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E24976K|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E25168K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E25101K|TTN-AS1_ENST00000588716.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000588244.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E32400K|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000589434.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32400	Ig-like 150.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGCTAATCTCTTTGAATGCT	0.428000													36	79					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810929	65810929	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65810929G>A	ENST00000312006.4	-	3	626	c.345C>T	c.(343-345)ttC>ttT	p.F115F	GAL3ST3_ENST00000527878.1_Silent_p.F115F	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	115					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						CCGGGTGCACGAAGTGCGCCG	0.692000													4	30					0	0	1	0	0
TNNI2	7136	broad.mit.edu	37	11	1862727	1862727	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1862727C>T	ENST00000381906.1	+	8	564	c.495C>T	c.(493-495)atC>atT	p.I165I	TNNI2_ENST00000381911.1_Silent_p.I165I|TNNI2_ENST00000252898.7_Silent_p.I165I|TNNI2_ENST00000381905.3_Silent_p.I165I	NM_001145829.1	NP_001139301.1	P48788	TNNI2_HUMAN	troponin I type 2 (skeletal, fast)	165					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding			lung(8)|prostate(1)|urinary_tract(1)	10		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GGAAGAACATCGAGGAGAAGT	0.642000													19	53					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102791757	102791757	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:102791757G>A	ENST00000504592.1	+	9	1232	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	BANK1_ENST00000322953.4_Missense_Mutation_p.E287K|BANK1_ENST00000508653.1_Missense_Mutation_p.E154K|BANK1_ENST00000428908.1_Missense_Mutation_p.E154K|BANK1_ENST00000444316.2_Missense_Mutation_p.E257K			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	287	DBB.				B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AAAGGCAAAGGAATGCCTATT	0.398000													28	55					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503592	140503592	+	Missense_Mutation	SNP	C	C	T	rs146284769		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140503592C>T	ENST00000194152.1	+	1	2012	c.2012C>T	c.(2011-2013)cCt>cTt	p.P671L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		671					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTACCTGCCTCTCCCTGAG	0.682000													35	153					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233514787	233514787	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233514787C>T	ENST00000366624.3	+	9	2296	c.2035C>T	c.(2035-2037)Cag>Tag	p.Q679*	MLK4_ENST00000366622.1_Nonsense_Mutation_p.Q125*	NM_032435.2	NP_115811.2																					GAAAGATGCTCAGAGAGAGAA	0.463000													43	93					0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50783766	50783766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50783766C>T	ENST00000540145.1	+	4	572	c.157C>T	c.(157-159)Cgt>Tgt	p.R53C	CYLD_ENST00000564326.1_Missense_Mutation_p.R53C|CYLD_ENST00000427738.3_Missense_Mutation_p.R53C|CYLD_ENST00000398568.2_Missense_Mutation_p.R53C|CYLD_ENST00000569418.1_Missense_Mutation_p.R53C|CYLD_ENST00000568704.2_Missense_Mutation_p.R53C|CYLD_ENST00000566206.1_Missense_Mutation_p.R53C|CYLD_ENST00000311559.9_Missense_Mutation_p.R53C			Q9NQC7	CYLD_HUMAN	cylindromatosis (turban tumor syndrome)	53					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				TATTCAAGATCGTTCTGTGGG	0.378000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis				30	98					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106121904	106121904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106121904G>A	ENST00000369704.3	+	3	549	c.415G>A	c.(415-417)Gga>Aga	p.G139R	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	139										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GCAGGGGTCTGGACTGTCAAT	0.488000													15	26					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711559	20711559	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20711559C>T	ENST00000315409.2	+	1	662	c.609C>T	c.(607-609)ccC>ccT	p.P203P		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CCCCAGCTCCCATAACTGAAT	0.423000													80	185					0	0	1	0	0
UBASH3A	53347	broad.mit.edu	37	21	43833575	43833575	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43833575C>T	ENST00000319294.6	+	5	641	c.610C>T	c.(610-612)Ctg>Ttg	p.L204L	UBASH3A_ENST00000291535.6_Intron|UBASH3A_ENST00000398367.1_Intron	NM_018961.3	NP_061834.1	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing A	204						cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						TGGCCCTAACCTGAGGCTGAG	0.527000													16	42					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17918740	17918740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17918740G>A	ENST00000318683.6	+	2	271	c.124G>A	c.(124-126)Gcg>Acg	p.A42T	B3GNT3_ENST00000595387.1_Missense_Mutation_p.A42T	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	42					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						GCAGCCACCGGCGATCCCCGA	0.677000													4	51					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88027354	88027354	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:88027354A>G	ENST00000227266.5	-	7	1326	c.1212T>C	c.(1210-1212)aaT>aaC	p.N404N		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	404					immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAACAGCATGATTAGTCAGCT	0.488000													16	57					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31341840	31341840	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31341840C>T	ENST00000544665.3	+	28	3264	c.3193C>T	c.(3193-3195)Ctc>Ttc	p.L1065F	ITGAM_ENST00000287497.8_Missense_Mutation_p.L1064F	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	1064					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GCATAACCACCTCCTGATCGT	0.617000													7	23					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2057320	2057320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2057320G>A	ENST00000262113.4	+	25	3319	c.3178G>A	c.(3178-3180)Gag>Aag	p.E1060K	MYOM2_ENST00000523438.1_Missense_Mutation_p.E485K	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1060					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTCTGACAGCGAGGTGAGTTC	0.473000													16	42					0	0	1	0	0
PTENP1	11191	broad.mit.edu	37	9	33676025	33676025	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33676025C>T	ENST00000532280.1	-	0	1472					NR_023917.1																						TTGCAAGTTCCGCCACTGAAC	0.418000													38	118					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187672	140187672	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140187672A>C	ENST00000530339.1	+	1	900	c.900A>C	c.(898-900)ggA>ggC	p.G300G	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Silent_p.G300G|PCDHA4_ENST00000512229.2_Silent_p.G300G|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATTACTGGACAAATTATTG	0.353000													29	128					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774735	122774735	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:122774735G>A	ENST00000227349.2	+	3	744	c.447G>A	c.(445-447)gaG>gaA	p.E149E	C11orf63_ENST00000307257.6_Silent_p.E149E|C11orf63_ENST00000531316.1_Silent_p.E149E	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	149										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		CGTTGCCGGAGTCCACGGACA	0.522000													55	140					0	0	1	0	0
PANX2	56666	broad.mit.edu	37	22	50615655	50615655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50615655C>T	ENST00000395842.2	+	2	514	c.514C>T	c.(514-516)Cgc>Tgc	p.R172C	PANX2_ENST00000159647.5_Missense_Mutation_p.R172C	NM_052839.3	NP_443071.2	Q96RD6	PANX2_HUMAN	pannexin 2	172					protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)	7		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		GGCCGAGGGCCGCGCGCCCAA	0.662000													7	17					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109686778	109686778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:109686778C>T	ENST00000277225.5	+	3	874	c.585C>T	c.(583-585)ccC>ccT	p.P195P	ZNF462_ENST00000457913.1_Silent_p.P195P			Q96JM2	ZN462_HUMAN	zinc finger protein 462	195					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CCACTGCTCCCCCACCTGCTC	0.512000													21	36					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164272587	164272587	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164272587C>T	ENST00000515560.1	+	4	2684	c.1162C>T	c.(1162-1164)Cat>Tat	p.H388Y	NPY5R_ENST00000506953.1_Missense_Mutation_p.H388Y|NPY5R_ENST00000338566.3_Missense_Mutation_p.H388Y			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	388					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				ACACCTTTTCCATGTGGTAAC	0.343000													39	91					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10235458	10235458	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10235458G>A	ENST00000418404.3	-	19	2419	c.2256C>T	c.(2254-2256)tcC>tcT	p.S752S	MYH13_ENST00000570743.1_Silent_p.S752S|RP11-401O9.3_ENST00000577743.1_RNA|MYH13_ENST00000252172.4_Silent_p.S752S			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	752	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCACATCGATGGAGTTGAGGA	0.547000													29	38					0	0	1	0	0
PON2	5445	broad.mit.edu	37	7	95035513	95035513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:95035513G>A	ENST00000536183.1	-	8	1070	c.887C>T	c.(886-888)tCc>tTc	p.S296F	PON2_ENST00000433091.2_Missense_Mutation_p.S263F|PON2_ENST00000483292.1_5'UTR|PON2_ENST00000222572.3_Missense_Mutation_p.S275F	NM_000305.2	NP_000296.2	Q15165	PON2_HUMAN	paraoxonase 2	275					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			GTCCCCCGAGGAAGGATCAAT	0.403000													48	138					0	0	1	0	0
C15orf27	123591	broad.mit.edu	37	15	76426617	76426617	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:76426617C>T	ENST00000388942.3	+	2	289	c.13C>T	c.(13-15)Cca>Tca	p.P5S		NM_152335.2	NP_689548.2	Q2M3C6	CO027_HUMAN	chromosome 15 open reading frame 27	5						integral to membrane				endometrium(1)|large_intestine(1)|lung(10)|pancreas(1)	13						GGCTGTGGCTCCATCTTTCAA	0.463000													62	64					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125025715	125025715	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125025715G>A	ENST00000522917.1	+	15	2072	c.1866G>A	c.(1864-1866)caG>caA	p.Q622Q	FER1L6_ENST00000399018.1_Silent_p.Q622Q|FER1L6-AS1_ENST00000518567.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	622						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AGATTTCACAGGAGGCACCTG	0.483000													42	88					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179576907	179576907	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179576907G>A	ENST00000589042.1	-	96	27874	c.27650C>T	c.(27649-27651)tCt>tTt	p.S9217F	TTN_ENST00000342992.6_Missense_Mutation_p.S7973F|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S8900F|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8900	Ig-like 75.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCCAACAGACACCTTAAC	0.463000													24	54					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002441	98002441	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:98002441G>A	ENST00000355273.2	+	1	710	c.710G>A	c.(709-711)aGa>aAa	p.R237K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						AAGTCTGTTAGAGGCGTAAGG	0.393000													22	67					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5013342	5013342	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5013342C>T	ENST00000380390.1	+	6	960	c.744C>T	c.(742-744)atC>atT	p.I248I	MMP26_ENST00000300762.1_Silent_p.I248I			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	248					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TCCAAAGGATCCAGCATTTGT	0.448000													24	46					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16060098	16060098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16060098C>T	ENST00000322107.1	+	1	281	c.281C>T	c.(280-282)aCc>aTc	p.T94I		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						CATTCCATCACCTTTGTGGCT	0.512000													95	303					0	0	1	0	0
HSPA4	3308	broad.mit.edu	37	5	132400719	132400719	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132400719C>T	ENST00000304858.2	+	2	444	c.155C>T	c.(154-156)gCt>gTt	p.A52V		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	52					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAGCAGCAGCTAAAAGCCAG	0.348000													12	108					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82785996	82785996	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82785996T>C	ENST00000265077.3	+	3	715	c.150T>C	c.(148-150)ccT>ccC	p.P50P	VCAN_ENST00000342785.4_Silent_p.P50P|VCAN_ENST00000502527.2_Silent_p.P50P|VCAN_ENST00000343200.5_Silent_p.P50P|VCAN_ENST00000512590.2_Silent_p.P2P|VCAN_ENST00000513984.1_Silent_p.P50P	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	50	Ig-like V-type.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAACGATGCCTACTTTGCCAC	0.438000													55	93					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24886121	24886121	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24886121C>T	ENST00000382554.3	+	9	5484	c.5166C>T	c.(5164-5166)ttC>ttT	p.F1722F		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1722	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						ACTGGGAATTCAAGAGGGCCC	0.637000													6	16					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147481403	147481403	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147481403G>A	ENST00000359874.3	+	15	1435	c.1362G>A	c.(1360-1362)gaG>gaA	p.E454E	SPINK5_ENST00000398454.1_Silent_p.E454E|SPINK5_ENST00000256084.7_Silent_p.E454E	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	454	Kazal-like 7.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACCAGAGAGAATGACCCCA	0.493000													31	87					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75740713	75740713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75740713C>T	ENST00000370855.5	-	6	303	c.190G>A	c.(190-192)Gac>Aac	p.D64N	SLC44A5_ENST00000469525.1_5'UTR|SLC44A5_ENST00000535611.1_Intron|SLC44A5_ENST00000370859.3_Missense_Mutation_p.D64N	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	64						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						CTTCTGGGGTCCCCATGTACC	0.493000													5	27					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45556204	45556204	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:45556204G>A	ENST00000588982.1	-	4	1788	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	ZBTB7C_ENST00000586438.1_Silent_p.F429F|ZBTB7C_ENST00000535628.2_Silent_p.F429F|ZBTB7C_ENST00000590800.1_Silent_p.F429F|ZBTB7C_ENST00000332053.2_Silent_p.F429F			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	429						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						AGTTGTGCACGAACTTGGCGT	0.592000													6	51					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256436	69256436	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:69256436G>A	ENST00000439696.2	-	2	1132	c.831C>T	c.(829-831)ttC>ttT	p.F277F	ZFP36L1_ENST00000336440.3_Silent_p.F277F|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	277					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCCGGAAGAGGAAGGTGGTCG	0.632000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	95					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1558805	1558805	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:1558805G>A	ENST00000572621.1	-	36	6091	c.5826C>T	c.(5824-5826)gcC>gcT	p.A1942A	PRPF8_ENST00000304992.6_Silent_p.A1942A			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1942	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCACATGTAGGGCACGCAGAA	0.498000													41	57					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73832317	73832317	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73832317G>A	ENST00000207549.4	-	16	1789	c.1410C>T	c.(1408-1410)ttC>ttT	p.F470F	UNC13D_ENST00000412096.2_Silent_p.F470F	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	470	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTTCAGGTGGAACCATTCAG	0.667000									Familial Hemophagocytic Lymphohistiocytosis				7	11					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43778170	43778170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43778170G>A	ENST00000372476.3	+	12	1904	c.1825G>A	c.(1825-1827)Gga>Aga	p.G609R	TIE1_ENST00000433781.2_Missense_Mutation_p.G254R	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	609	Fibronectin type-III 2.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTCCTGACGGGACTCACGCC	0.711000													13	44					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121016536	121016536	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121016536G>A	ENST00000392793.1	+	12	4087	c.3816G>A	c.(3814-3816)aaG>aaA	p.K1272K	TECTA_ENST00000264037.2_Silent_p.K1272K|TECTA_ENST00000478058.1_3'UTR			O75443	TECTA_HUMAN	tectorin alpha	1272	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCTGGGTGAAGAGGGACACCT	0.592000													25	103					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552399	1552399	+	Missense_Mutation	SNP	G	G	A	rs142083473	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1552399G>A	ENST00000381605.4	-	3	782	c.718C>T	c.(718-720)Cgt>Tgt	p.R240C	RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000262929.5_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	240	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.R240C(1)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						GCAGTCCCACGAAGAGGGTCC	0.627000													31	76					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78380676	78380676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78380676C>T	ENST00000278550.7	-	32	7176	c.6714G>A	c.(6712-6714)cgG>cgA	p.R2238R		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GGATGTCATACCGTAGTGGTG	0.557000													62	109					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84488747	84488747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:84488747G>A	ENST00000286744.5	+	6	772	c.548G>A	c.(547-549)gGa>gAa	p.G183E	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G183E	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	183						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GTACTGGATGGAACTCGTTGC	0.532000													18	69					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121659731	121659731	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:121659731C>T	ENST00000489711.1	+	22	2455	c.2067C>T	c.(2065-2067)ttC>ttT	p.F689F	SLC15A2_ENST00000295605.2_Silent_p.F658F	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	689					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GCCTGATCTTCTCCATCATGG	0.458000													34	77					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32933287	32933287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:32933287G>A	ENST00000383763.4	+	4	2654	c.2591G>A	c.(2590-2592)cGa>cAa	p.R864Q		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	864					multicellular organismal development	cytoplasm	zinc ion binding	p.R864Q(1)		breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GGCAACAATCGAATCCTCGTC	0.512000													17	161					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753646	76753646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76753646C>T	ENST00000536229.3	+	1	1965	c.1256C>T	c.(1255-1257)tCc>tTc	p.S419F	SALL3_ENST00000537592.2_Missense_Mutation_p.S552F|SALL3_ENST00000575389.2_Missense_Mutation_p.S552F			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	552					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCCAGCCGCTCCCCGCAGAGG	0.746000													4	18					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17053361	17053361	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:17053361C>T	ENST00000418129.2	+	2	2610	c.2145C>T	c.(2143-2145)ttC>ttT	p.F715F	PLCL2_ENST00000396755.2_Silent_p.F715F|PLCL2_ENST00000432376.1_Silent_p.F715F	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	841	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GGGATGAATTCATCGGCCAGT	0.468000													41	102					0	0	1	0	0
UGT1A8	54576	broad.mit.edu	37	2	234527192	234527192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234527192G>A	ENST00000373450.4	+	1	902	c.839G>A	c.(838-840)gGa>gAa	p.G280E		NM_019076.4	NP_061949.3														breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGCCATCAGGGAAAGCCATTG	0.398000													107	312					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961116	1961116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1961116G>A	ENST00000217305.2	-	4	843	c.618C>T	c.(616-618)cgC>cgT	p.R206R	PDYN_ENST00000540134.1_Silent_p.R206R|PDYN_ENST00000539905.1_Silent_p.R206R|RP4-684O24.5_ENST00000446562.1_RNA	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	206					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGCCCCCATAGCGTTTGTACA	0.592000													53	138					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544344	82544344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82544344C>T	ENST00000423517.2	-	7	13295	c.12958G>A	c.(12958-12960)Gag>Aag	p.E4320K	PCLO_ENST00000333891.8_Missense_Mutation_p.E4320K|PCLO_ENST00000437081.1_Missense_Mutation_p.E1040K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4251					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCTTCAGCCTCTTGAGCTTTC	0.443000													14	28					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51172764	51172764	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51172764G>A	ENST00000440970.1	-	2	3509	c.3078C>T	c.(3076-3078)ctC>ctT	p.L1026L	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.L1123L|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1123					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GCAGAGCAGGGAGCAGAACTG	0.567000													13	51					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128498132	128498132	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128498132C>T	ENST00000325888.8	+	47	8112	c.7851C>T	c.(7849-7851)tcC>tcT	p.S2617S	FLNC_ENST00000346177.6_Silent_p.S2584S|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2617	Hinge 2.|Interaction with INPPL1.|Self-association site, tail (By similarity).				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TGACCAAGTCCTCCTCAAGCC	0.637000													7	23					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122420051	122420051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122420051C>T	ENST00000474629.2	+	6	2916	c.2650C>T	c.(2650-2652)Cgc>Tgc	p.R884C		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	884	Macro 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		AGTGGGGCCCCGCTGGAGCGG	0.557000													9	23					0	0	1	0	0
TMEM184A	202915	broad.mit.edu	37	7	1587388	1587388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:1587388C>T	ENST00000297477.5	-	8	1318	c.1002G>A	c.(1000-1002)gaG>gaA	p.E334E		NM_001097620.1	NP_001091089.1	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	334						integral to membrane				endometrium(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)		CTGGTGAATTCTCCTTCTTCT	0.637000													6	22					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65264525	65264525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65264525G>A	ENST00000389722.3	-	9	1157	c.1104C>T	c.(1102-1104)acC>acT	p.T368T	SPTB_ENST00000389720.3_Silent_p.T368T|SPTB_ENST00000389721.5_Silent_p.T368T|SPTB_ENST00000556626.1_Silent_p.T368T|SPTB_ENST00000542895.1_Silent_p.T368T	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	368					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GGGACTGGATGGTAAAAAGTA	0.428000													14	129					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78944602	78944602	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:78944602G>A	ENST00000286627.5	-	4	1627	c.675C>T	c.(673-675)ttC>ttT	p.F225F	KCNMA1_ENST00000404857.1_Silent_p.F225F|KCNMA1_ENST00000372443.1_Silent_p.F225F|KCNMA1_ENST00000286628.8_Silent_p.F225F|KCNMA1_ENST00000372440.1_Silent_p.F225F|KCNMA1_ENST00000354353.5_Silent_p.F225F|KCNMA1_ENST00000406533.3_Silent_p.F225F|KCNMA1_ENST00000404771.3_Silent_p.F225F	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	225					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	AGTAGAGAAGGAAGAACACGT	0.453000													33	99					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14479246	14479246	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:14479246G>A	ENST00000581457.1	-	0	662					NR_024076.1																						ACAGGAGCACGAAGCGCAGCA	0.612000													9	21					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53844098	53844098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53844098C>T	ENST00000288139.3	+	48	6143	c.6025C>T	c.(6025-6027)Ccc>Tcc	p.P2009S	CACNA1D_ENST00000544977.1_3'UTR|CACNA1D_ENST00000422281.2_Missense_Mutation_p.P1965S|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P1989S	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1989					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	AGCAACCCCTCCCTACCGGGA	0.632000													15	85					0	0	1	0	0
TRAV38-2DV8	28643	broad.mit.edu	37	14	22749075	22749075	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22749075C>T	ENST00000390465.2	+	0	88																											TGATCTCCACCTGTCTTGGTA	0.468000													45	96					0	0	1	0	0
MRPL1	65008	broad.mit.edu	37	4	78804493	78804493	+	Missense_Mutation	SNP	G	G	A	rs116727867	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:78804493G>A	ENST00000315567.8	+	3	570	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K	MRPL1_ENST00000506674.1_3'UTR	NM_020236.3	NP_064621.3	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1	81							RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)	17						TATGGAAGGCGAACCTGAGGA	0.333000													27	72					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43376039	43376039	+	Missense_Mutation	SNP	C	C	T	rs1058692		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43376039C>T	ENST00000244296.2	-	3	726	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	PSG1_ENST00000403380.3_Intron|PSG1_ENST00000312439.6_Missense_Mutation_p.E197K|PSG1_ENST00000595356.1_Missense_Mutation_p.E197K|PSG1_ENST00000595124.1_Intron|PSG1_ENST00000436291.2_Missense_Mutation_p.E197K	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				CTGTTGGTTTCGGACAGCTTC	0.527000													34	579					0	0	1	0	0
IL1R2	7850	broad.mit.edu	37	2	102626047	102626047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102626047C>T	ENST00000332549.3	+	3	320	c.91C>T	c.(91-93)Cgt>Tgt	p.R31C	IL1R2_ENST00000441002.1_Missense_Mutation_p.R31C|IL1R2_ENST00000393414.2_Missense_Mutation_p.R31C	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	31	Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	CTGCCGGTTTCGTGGGAGGCA	0.612000													53	143					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15364970	15364970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15364970G>A	ENST00000263377.2	-	11	2372	c.2151C>T	c.(2149-2151)tcC>tcT	p.S717S	BRD4_ENST00000360016.5_Silent_p.S717S|BRD4_ENST00000371835.4_Silent_p.S717S	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	717	Ser-rich.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			AACCTGTTTCGGAGTCTTCGC	0.542000			T	C15orf55	lethal midline carcinoma of young people								7	43					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51382209	51382209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51382209C>T	ENST00000216392.7	-	11	1580	c.1248G>A	c.(1246-1248)gtG>gtA	p.V416V	PYGL_ENST00000532462.1_Silent_p.V416V|PYGL_ENST00000544180.2_Silent_p.V382V	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	416					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	GAAACAAGGCCACAATTCTCT	0.448000													25	68					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52174539	52174539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52174539G>A	ENST00000354534.5	+	21	4104	c.3926G>A	c.(3925-3927)cGa>cAa	p.R1309Q	SCN8A_ENST00000545061.1_Intron	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1309					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GCCTTATCACGATTTGAAGGG	0.458000													10	26					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181740436	181740436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181740436G>A	ENST00000526775.1	+	35	4997	c.4832G>A	c.(4831-4833)gGa>gAa	p.G1611E	CACNA1E_ENST00000367567.4_Missense_Mutation_p.G1237E|CACNA1E_ENST00000358338.5_Missense_Mutation_p.G1562E|CACNA1E_ENST00000367570.1_Missense_Mutation_p.G1630E|CACNA1E_ENST00000360108.3_Missense_Mutation_p.G1611E|CACNA1E_ENST00000367573.2_Missense_Mutation_p.G1630E|CACNA1E_ENST00000357570.5_Missense_Mutation_p.G1581E	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1630					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AAGGTATTTGGAAACATAAAA	0.463000													5	3					0	0	1	0	0
CLRN3	119467	broad.mit.edu	37	10	129682033	129682033	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129682033G>A	ENST00000368671.3	-	2	498	c.336C>T	c.(334-336)ttC>ttT	p.F112F		NM_152311.3	NP_689524.1	Q8NCR9	CLRN3_HUMAN	clarin 3	112						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				TGCTGTTGTAGAAGGTAAACC	0.532000													44	90					0	0	1	0	0
TRAV6	6956	broad.mit.edu	37	14	22237033	22237033	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22237033G>A	ENST00000390428.3	+	0	117																											TTCTGCCTAGGGGTGAAGAGC	0.473000													6	16					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699483	52699483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52699483G>A	ENST00000293525.5	+	6	989	c.937G>A	c.(937-939)Gag>Aag	p.E313K	KRT86_ENST00000544024.1_Missense_Mutation_p.E313K|KRT86_ENST00000423955.2_Missense_Mutation_p.E313K	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	313	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		CAGGCACGGGGAGACCCTGCG	0.597000													7	81					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45404008	45404008	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45404008C>T	ENST00000389039.6	-	5	856	c.471G>A	c.(469-471)tgG>tgA	p.W157*	DUOX2_ENST00000603300.1_Nonsense_Mutation_p.W157*			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	157	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TCTCGGGGTCCCAGCGGCTCC	0.726000													5	13					0	0	1	0	0
LELP1	149018	broad.mit.edu	37	1	153177391	153177391	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153177391C>T	ENST00000368747.1	+	2	318	c.208C>T	c.(208-210)Cct>Tct	p.P70S		NM_001010857.1	NP_001010857.1	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	70	Cys/Pro-rich.									NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|pancreas(1)|prostate(1)	19	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCATCCTGCCCTCCCCAGCC	0.612000													24	44					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162497	90162497	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:90162497C>T	ENST00000564451.1	+	0	1850				TUBB8P7_ENST00000567960.1_RNA																							TTCACCGAGGCCGAGAGCAAC	0.542000													45	102					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55924936	55924936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55924936G>A	ENST00000244728.5	-	28	2885	c.2488C>T	c.(2488-2490)Cct>Tct	p.P830S	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000370808.2_Intron|COL21A1_ENST00000535941.1_Missense_Mutation_p.P830S|COL21A1_ENST00000370819.1_Missense_Mutation_p.P827S	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	830	Collagen-like 6.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GGTGGCCCAGGAATACCCGGG	0.522000													14	36					0	0	1	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32891041	32891041	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32891041C>T	ENST00000330048.5	-	0	2925					NR_003083.2																						TACATCCCACCCTGGGGGACA	0.597000													22	70					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28441679	28441679	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28441679A>T	ENST00000261609.7	-	51	8156	c.8048T>A	c.(8047-8049)tTt>tAt	p.F2683Y		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2683					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTGCTGGGGAAAGTCGACAAT	0.413000													13	83					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10538689	10538689	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10538689C>T	ENST00000583535.1	-	30	4254	c.4167G>A	c.(4165-4167)gaG>gaA	p.E1389E	MYH3_ENST00000226209.7_Silent_p.E1389E	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1389					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CGCACTTGGCCTCCTCCAGCT	0.488000													59	74					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25585831	25585831	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:25585831G>T	ENST00000269141.3	-	6	1252	c.829C>A	c.(829-831)Cct>Act	p.P277T	CDH2_ENST00000399380.3_Missense_Mutation_p.P246T	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	277	Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GATCCCTCAGGAACTGTCCCA	0.398000													33	98					1.22384e-17	1.23101e-17	1	1	0
PCDHB3	56132	broad.mit.edu	37	5	140480800	140480800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140480800G>A	ENST00000231130.2	+	1	567	c.567G>A	c.(565-567)agG>agA	p.R189R	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		189	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGACGGAAGGAAGTACCCGG	0.567000													23	82					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	19955098	19955098	+	Silent	SNP	C	C	T	rs113762718		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:19955098C>T	ENST00000396085.1	+	7	1669	c.1308C>T	c.(1306-1308)ttC>ttT	p.F436F	NAV2_ENST00000349880.4_Silent_p.F436F|NAV2_ENST00000527559.2_Silent_p.F388F|NAV2_ENST00000540292.1_Silent_p.F390F|NAV2_ENST00000360655.4_Silent_p.F372F|NAV2_ENST00000396087.3_Silent_p.F459F	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	459						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						TGCCCAGCTTCGAAGAGAGCG	0.612000													33	75					0	0	1	0	0
CHCHD5	84269	broad.mit.edu	37	2	113343825	113343825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113343825C>T	ENST00000409719.1	+	3	245	c.192C>T	c.(190-192)gcC>gcT	p.A64A	CHCHD5_ENST00000489052.1_3'UTR|CHCHD5_ENST00000324913.5_Silent_p.A64A			Q9BSY4	CHCH5_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 5	64	CHCH.									NS(1)|endometrium(1)|large_intestine(4)|urinary_tract(1)	7						CTTTTGAGGCCTTCGAGGAGT	0.637000													19	54					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6309800	6309800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6309800G>A	ENST00000301452.4	-	4	473	c.396C>T	c.(394-396)acC>acT	p.T132T		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	132						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						AGGACAGAAGGGTGCTGACCA	0.597000													13	59					0	0	1	0	0
CALU	813	broad.mit.edu	37	7	128399014	128399014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128399014C>T	ENST00000542996.2	+	5	1472	c.529C>T	c.(529-531)Ctc>Ttc	p.L177F	CALU_ENST00000479257.1_Missense_Mutation_p.L177F|CALU_ENST00000535011.2_Missense_Mutation_p.L169F|CALU_ENST00000249364.4_Missense_Mutation_p.L169F|CALU_ENST00000535623.1_3'UTR|CALU_ENST00000538546.1_Missense_Mutation_p.L18F|CALU_ENST00000449187.2_Missense_Mutation_p.L169F	NM_001199672.1	NP_001186601.1	O43852	CALU_HUMAN	calumenin	169	EF-hand 3.				platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding			kidney(2)|large_intestine(3)|lung(5)	10						GGATGGAGACCTCATTGCCAC	0.428000													84	215					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126315103	126315103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126315103G>A	ENST00000335110.5	+	1	13	c.13G>A	c.(13-15)Gta>Ata	p.V5I	FAT4_ENST00000394329.3_Intron			Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1179					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGTAACAACGGTAGTGGCAGT	0.388000													15	44					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72998408	72998408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:72998408C>T	ENST00000322038.5	+	2	1495	c.911C>T	c.(910-912)cCc>cTc	p.P304L	TSHZ1_ENST00000580243.1_Missense_Mutation_p.P349L	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	349						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		AAACTGGTCCCCTCCACCAAA	0.592000													23	67					0	0	1	0	0
OR2AT4	341152	broad.mit.edu	37	11	74800531	74800531	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74800531G>A	ENST00000305159.3	-	1	268	c.228C>T	c.(226-228)atC>atT	p.I76I		NM_001005285.1	NP_001005285.1	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT, member 4	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	12						TGGTGAAAAGGATGTCCAAGG	0.527000													16	43					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51758499	51758499	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51758499G>A	ENST00000251076.5	-	30	7686	c.7399C>T	c.(7399-7401)Cct>Tct	p.P2467S	RP11-707P17.1_ENST00000561007.1_RNA|DMXL2_ENST00000543779.2_Missense_Mutation_p.P2468S|DMXL2_ENST00000449909.3_Missense_Mutation_p.P1831S	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2467						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TCAGACAAAGGAAGAAATGGC	0.244000													29	82					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137717743	137717743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:137717743C>T	ENST00000343735.4	+	1	167	c.33C>T	c.(31-33)ttC>ttT	p.F11F		NM_001002026.2	NP_001002026.1	P56856	CLD18_HUMAN	claudin 18	11					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						GCTTGGGGTTCGTGGTTTCAC	0.557000													28	78					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60908263	60908263	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60908263G>A	ENST00000252999.3	-	26	3231	c.3165C>T	c.(3163-3165)ttC>ttT	p.F1055F		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1055	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGCCGAGGGGAAGCCATCCA	0.711000													12	31					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23526574	23526574	+	Silent	SNP	G	G	A	rs112001060		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:23526574G>A	ENST00000296682.3	+	11	1559	c.1377G>A	c.(1375-1377)agG>agA	p.R459R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	459					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.R459S(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TCAAAGAAAGGTCCAAACTCT	0.468000										HNSCC(3;0.000094)			10	28					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82583815	82583815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82583815C>T	ENST00000423517.2	-	5	6791	c.6454G>A	c.(6454-6456)Gaa>Aaa	p.E2152K	PCLO_ENST00000333891.8_Missense_Mutation_p.E2152K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2083					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTTGAATTTCTCTTGTATAA	0.413000													33	63					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26157080	26157080	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26157080C>T	ENST00000335473.7	+	2	271	c.21C>T	c.(19-21)ctC>ctT	p.L7L	MYO18B_ENST00000536101.1_Silent_p.L7L|MYO18B_ENST00000407587.2_Silent_p.L7L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	7						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CATCACGCCTCGCCCTGTGGG	0.592000													25	99					0	0	1	0	0
ARIH2	10425	broad.mit.edu	37	3	49012254	49012254	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49012254C>T	ENST00000356401.4	+	10	1232	c.893C>T	c.(892-894)cCc>cTc	p.P298L	ARIH2_ENST00000449376.1_Missense_Mutation_p.P298L|ARIH2_ENST00000490095.1_3'UTR	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	298					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		CCTCAGTGTCCCAAGTGCAAC	0.498000													28	77					0	0	1	0	0
IL32	9235	broad.mit.edu	37	16	3119355	3119355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3119355G>A	ENST00000525643.2	+	7	898	c.566G>A	c.(565-567)tGa>tAa	p.*189*	IL32_ENST00000382213.3_Silent_p.*180*|IL32_ENST00000529699.1_Silent_p.*169*|IL32_ENST00000552664.1_Silent_p.*189*|IL32_ENST00000548476.1_Silent_p.*235*|IL32_ENST00000551122.1_Silent_p.*132*|IL32_ENST00000528163.2_Silent_p.*189*|IL32_ENST00000440815.3_Silent_p.*189*|IL32_ENST00000008180.9_Silent_p.*169*|IL32_ENST00000526464.2_Silent_p.*189*|IL32_ENST00000444393.3_Silent_p.*189*|IL32_ENST00000396890.2_Silent_p.*235*|IL32_ENST00000325568.5_Silent_p.*189*|IL32_ENST00000552936.1_Silent_p.*213*|IL32_ENST00000396887.3_Silent_p.*132*|IL32_ENST00000530538.2_Silent_p.*189*|IL32_ENST00000548246.1_Silent_p.*149*|IL32_ENST00000548652.1_Silent_p.*180*|IL32_ENST00000530890.1_Silent_p.*169*|IL32_ENST00000533097.2_Silent_p.*189*|IL32_ENST00000531965.1_Silent_p.*179*|IL32_ENST00000549213.1_Silent_p.*132*|IL32_ENST00000552356.1_Silent_p.*169*|IL32_ENST00000534507.1_Silent_p.*235*|IL32_ENST00000551513.1_Silent_p.*226*|IL32_ENST00000529550.1_Silent_p.*189*			P24001	IL32_HUMAN	interleukin 32	0					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						TCCTCAAAATGAAGATACTGA	0.617000													20	186					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26294333	26294333	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26294333G>A	ENST00000335473.7	+	29	4978	c.4728G>A	c.(4726-4728)agG>agA	p.R1576R	CTA-125H2.2_ENST00000594856.1_RNA|CTA-125H2.2_ENST00000594585.1_RNA|CTA-125H2.2_ENST00000597548.1_RNA|MYO18B_ENST00000536101.1_Silent_p.R1576R|MYO18B_ENST00000407587.2_Silent_p.R1577R|CTA-125H2.2_ENST00000600269.1_RNA|CTA-125H2.2_ENST00000597284.1_RNA|CTA-125H2.2_ENST00000599792.1_RNA|CTA-125H2.2_ENST00000599080.1_RNA|CTA-125H2.2_ENST00000600211.1_RNA|CTA-125H2.2_ENST00000600903.1_RNA|CTA-125H2.2_ENST00000595102.1_RNA|CTA-125H2.2_ENST00000453457.2_RNA|CTA-125H2.2_ENST00000594542.1_RNA	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1576	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AACTGAAGAGGAAGTGCCACC	0.493000													28	72					0	0	1	0	0
TMEM196	256130	broad.mit.edu	37	7	19765192	19765192	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:19765192C>T	ENST00000405844.1	-	3	1099	c.404G>A	c.(403-405)aGg>aAg	p.R135K	TMEM196_ENST00000405764.3_Missense_Mutation_p.R135K|TMEM196_ENST00000493519.1_Missense_Mutation_p.R67K|TMEM196_ENST00000433641.1_Missense_Mutation_p.R67K|TMEM196_ENST00000422233.1_Missense_Mutation_p.R67K			Q5HYL7	TM196_HUMAN	transmembrane protein 196	141						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						TGAGAACATCCTCCTCTGTTC	0.507000													22	42					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149477866	149477866	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149477866G>A	ENST00000378016.2	+	0	1637							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGTGCCCACAGCGTGTGCAGG	0.657000													5	10					0	0	1	0	0
ADAT3	113179	broad.mit.edu	37	19	1912832	1912832	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1912832C>T	ENST00000329478.2	+	2	1006	c.786C>T	c.(784-786)ttC>ttT	p.F262F	SCAMP4_ENST00000316097.8_Intron|SCAMP4_ENST00000409472.1_Intron|SCAMP4_ENST00000414057.2_Intron|ADAT3_ENST00000602400.1_Silent_p.F246F			Q96EY9	ADAT3_HUMAN	adenosine deaminase, tRNA-specific 3	246					tRNA processing		hydrolase activity|zinc ion binding	p.F246F(1)		breast(1)|kidney(3)|pancreas(1)|skin(2)	7		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGACCCTTCCCCGCCTGCT	0.726000													5	15					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162833346	162833346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:162833346G>A	ENST00000375514.5	+	25	3534	c.3247G>A	c.(3247-3249)Gat>Aat	p.D1083N	SLC4A10_ENST00000446997.1_Missense_Mutation_p.D1102N|SLC4A10_ENST00000272716.5_Missense_Mutation_p.D1072N|SLC4A10_ENST00000421911.1_Intron|SLC4A10_ENST00000415876.2_Missense_Mutation_p.D1072N	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	1102					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GATTACTGCCGATAACTCAAA	0.348000													4	17					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117849481	117849481	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117849481C>T	ENST00000350763.4	-	3	940	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K	TNC_ENST00000341037.4_Missense_Mutation_p.E177K|TNC_ENST00000542877.1_Missense_Mutation_p.E177K|TNC_ENST00000340094.3_Missense_Mutation_p.E177K|TNC_ENST00000537320.1_Missense_Mutation_p.E177K|TNC_ENST00000535648.1_Missense_Mutation_p.E177K|TNC_ENST00000423613.2_Missense_Mutation_p.E177K|TNC_ENST00000345230.3_Missense_Mutation_p.E177K|TNC_ENST00000346706.3_Missense_Mutation_p.E177K	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	177	EGF-like 1; incomplete.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						CAGCCAGGTTCGCAGACACAG	0.582000													26	79					0	0	1	0	0
GAD1	2571	broad.mit.edu	37	2	171686121	171686121	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:171686121C>T	ENST00000358196.3	+	4	832	c.282C>T	c.(280-282)gaC>gaT	p.D94D	GAD1_ENST00000429023.1_3'UTR|GAD1_ENST00000344257.5_Silent_p.D94D|GAD1_ENST00000375272.1_Silent_p.D94D	NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	94					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CAGAGACTGACTTCTCTAATC	0.517000													33	103					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99640962	99640962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:99640962G>A	ENST00000345514.2	-	3	2264	c.1998C>T	c.(1996-1998)ttC>ttT	p.F666F	BCL11B_ENST00000357195.3_Silent_p.F737F|BCL11B_ENST00000443726.2_Silent_p.F543F	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	737						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		ACGACGTGGCGAAGGGCGACT	0.706000			T	TLX3	T-ALL								9	11					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9512533	9512533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9512533C>T	ENST00000402466.1	+	20	3589	c.2821C>T	c.(2821-2823)Cgt>Tgt	p.R941C	SETD5_ENST00000402198.1_Missense_Mutation_p.R1039C|SETD5_ENST00000407969.1_Missense_Mutation_p.R1058C|SETD5_ENST00000302463.6_Missense_Mutation_p.R941C|SETD5_ENST00000406341.1_Missense_Mutation_p.R1039C			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1039										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGACCTCTCTCGTGGATCCTT	0.478000													8	11					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166234156	166234156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166234156G>A	ENST00000375437.2	+	23	4594	c.4304G>A	c.(4303-4305)cGa>cAa	p.R1435Q	SCN2A_ENST00000375427.2_Missense_Mutation_p.R1435Q|SCN2A_ENST00000357398.3_Missense_Mutation_p.R1435Q|SCN2A_ENST00000283256.6_Missense_Mutation_p.R1435Q	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1435					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTTGATTCACGAAATGTAAGT	0.269000													34	94					0	0	1	0	0
FRMD4B	23150	broad.mit.edu	37	3	69230763	69230763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:69230763G>A	ENST00000542259.1	-	22	2427	c.1976C>T	c.(1975-1977)tCc>tTc	p.S659F	FRMD4B_ENST00000398540.3_Missense_Mutation_p.S713F|FRMD4B_ENST00000478263.1_Missense_Mutation_p.S365F			Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	713						cytoplasm|cytoskeleton	binding			NS(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(2)	19		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TTTGGAGAGGGAGAAAAATGG	0.517000													22	65					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	769422	769422	+	Missense_Mutation	SNP	G	G	A	rs142141660		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:769422G>A	ENST00000297440.6	+	2	738	c.718G>A	c.(718-720)Ggg>Agg	p.G240R	HEATR2_ENST00000313147.5_Missense_Mutation_p.G240R|HEATR2_ENST00000438961.1_3'UTR	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	240							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		TTTTGGCAACGGGAAGTCCGT	0.572000													18	41					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101375429	101375429	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101375429G>A	ENST00000344327.3	-	2	695	c.271C>T	c.(271-273)Cgc>Tgc	p.R91C	TRPC6_ENST00000532133.1_Missense_Mutation_p.R91C|TRPC6_ENST00000360497.4_Missense_Mutation_p.R91C|TRPC6_ENST00000348423.4_Missense_Mutation_p.R91C	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	91					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CTTGTGGAGCGATCACTAAAC	0.507000													49	127					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24390596	24390596	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24390596C>T	ENST00000330966.7	-	30	3759	c.3597G>A	c.(3595-3597)ggG>ggA	p.G1199G	MYOM3_ENST00000338909.5_Silent_p.G89G|MYOM3_ENST00000374434.3_Silent_p.G1196G|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1196	Ig-like C2-type 3.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TGTCGTCCTCCCCTCGATCGT	0.552000													34	99					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73957010	73957010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73957010G>A	ENST00000358602.4	-	29	6451	c.6335C>T	c.(6334-6336)cCg>cTg	p.P2112L	ANKRD17_ENST00000509867.2_Missense_Mutation_p.P1999L|ANKRD17_ENST00000330838.6_Missense_Mutation_p.P1861L	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	2112					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AACAGATCCCGGAGGTTGTTG	0.483000													60	112					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125103744	125103744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125103744G>A	ENST00000522917.1	+	34	4678	c.4472G>A	c.(4471-4473)gGa>gAa	p.G1491E	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.G1491E	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1491						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAGCTGGATGGACCCTACTTT	0.453000													46	80					0	0	1	0	0
ITGB2	3689	broad.mit.edu	37	21	46310067	46310067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:46310067C>T	ENST00000397850.2	-	13	1935	c.1483G>A	c.(1483-1485)Gga>Aga	p.G495R	ITGB2_ENST00000397852.1_Missense_Mutation_p.G495R|ITGB2_ENST00000302347.5_Missense_Mutation_p.G495R|ITGB2_ENST00000397857.1_Missense_Mutation_p.G495R|ITGB2_ENST00000355153.4_Missense_Mutation_p.G495R|ITGB2_ENST00000397854.3_Missense_Mutation_p.G438R			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	495	Cysteine-rich tandem repeats.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	CGGCAGCTTCCTTCCAGCTCC	0.632000													12	25					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29222072	29222072	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29222072C>T	ENST00000379558.4	+	4	516	c.165C>T	c.(163-165)gcC>gcT	p.A55A	FAM179A_ENST00000403861.2_Silent_p.A55A	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	55			A -> T (in dbSNP:rs13009279).				binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGCCAAGAGCCCTGCTGAACA	0.622000													6	20					0	0	1	0	0
C17orf77	146723	broad.mit.edu	37	17	72588686	72588686	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72588686G>A	ENST00000392620.1	+	3	863	c.501G>A	c.(499-501)ggG>ggA	p.G167G	C17orf77_ENST00000328023.2_Silent_p.G167G	NM_152460.2	NP_689673.2	Q96MU5	CQ077_HUMAN	chromosome 17 open reading frame 77	167						extracellular region		p.G167G(1)		breast(2)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11						GGAGCTGCGGGATCTACTGCC	0.597000													18	35					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52596062	52596062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52596062G>A	ENST00000395489.2	-	8	751	c.355C>T	c.(355-357)Ctc>Ttc	p.L119F	A1CF_ENST00000373993.1_Missense_Mutation_p.L126F|A1CF_ENST00000282641.2_Missense_Mutation_p.L126F|A1CF_ENST00000373997.3_Missense_Mutation_p.L126F|A1CF_ENST00000374001.1_Missense_Mutation_p.L126F|A1CF_ENST00000395495.1_Missense_Mutation_p.L126F|A1CF_ENST00000373995.3_Missense_Mutation_p.L134F	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	126	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ACCCCTAAGAGGCGCCCATTT	0.438000													27	53					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47630061	47630061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:47630061C>T	ENST00000546455.1	+	4	1946	c.1215C>T	c.(1213-1215)ccC>ccT	p.P405P	PCED1B_ENST00000432328.1_Silent_p.P405P					PC-esterase domain containing 1B																		GGTATCGTCCCCGTGGCCCCT	0.592000													21	41					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33588480	33588480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:33588480G>A	ENST00000404816.2	+	29	4647	c.4294G>A	c.(4294-4296)Gga>Aga	p.G1432R	LTBP1_ENST00000402934.1_Missense_Mutation_p.G1051R|LTBP1_ENST00000354476.3_Missense_Mutation_p.G1433R|LTBP1_ENST00000404525.1_Missense_Mutation_p.G1053R|LTBP1_ENST00000407925.1_Missense_Mutation_p.G1106R|LTBP1_ENST00000272273.5_Missense_Mutation_p.G330R|LTBP1_ENST00000390003.4_Missense_Mutation_p.G1107R|LTBP1_ENST00000418533.2_Missense_Mutation_p.G1064R			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1432	EGF-like 15; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCTACTTTTTGGACAAGAAAT	0.383000													22	77					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122667443	122667443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122667443G>A	ENST00000195173.4	-	3	541	c.238C>T	c.(238-240)Cac>Tac	p.H80Y	SEMA5B_ENST00000465147.1_5'UTR|SEMA5B_ENST00000357599.3_Missense_Mutation_p.H80Y|SEMA5B_ENST00000451055.2_Missense_Mutation_p.H134Y			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	80					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		CTGGAGAGGTGGGACACCAGC	0.627000													10	42					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123239513	123239513	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123239513G>A	ENST00000358487.5	-	18	2596	c.2324C>T	c.(2323-2325)cCt>cTt	p.P775L	FGFR2_ENST00000356226.4_Missense_Mutation_p.P658L|FGFR2_ENST00000369061.4_Missense_Mutation_p.P663L|FGFR2_ENST00000346997.2_Missense_Mutation_p.P773L|FGFR2_ENST00000369060.4_Missense_Mutation_p.P659L|FGFR2_ENST00000457416.2_Missense_Mutation_p.P776L|FGFR2_ENST00000357555.5_Intron|FGFR2_ENST00000369059.1_Missense_Mutation_p.P661L|FGFR2_ENST00000478859.1_Missense_Mutation_p.P547L	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	775					angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CTGTTCGAGAGGTTGGCTGAG	0.453000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				59	136					0	0	1	0	0
IGKV3-7	28915	broad.mit.edu	37	2	89278196	89278196	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89278196G>A	ENST00000390247.2	-	0	235																											CTAACACTCTGACTGGCCCTG	0.547000													24	121					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52946055	52946055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52946055G>A	ENST00000295213.4	+	9	1699	c.1325G>A	c.(1324-1326)gGa>gAa	p.G442E	SPATA18_ENST00000419395.2_Missense_Mutation_p.G410E	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	442					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			ATTGCATATGGAGCAGATGGA	0.418000													53	160					0	0	1	0	0
SLC38A7	55238	broad.mit.edu	37	16	58713945	58713945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58713945G>A	ENST00000570101.1	-	2	969	c.86C>T	c.(85-87)cCc>cTc	p.P29L	SLC38A7_ENST00000566953.1_Intron|SLC38A7_ENST00000219320.4_Missense_Mutation_p.P29L|SLC38A7_ENST00000564391.1_Missense_Mutation_p.P29L|SLC38A7_ENST00000564100.1_Missense_Mutation_p.P29L|SLC38A7_ENST00000564010.1_Intron			Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	29					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	13						GTCCACACAGGGACTCTGCAG	0.622000													4	20					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131234714	131234714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:131234714G>A	ENST00000298542.4	-	2	263	c.88C>T	c.(88-90)Ctg>Ttg	p.L30L	FRMD7_ENST00000464296.1_Silent_p.L30L|RP1-305B16.2_ENST00000513703.1_RNA	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	30	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					CTGCAACTCAGGTTAAACAAT	0.373000													46	29					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207133	58207133	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58207133C>T	ENST00000377918.3	+	1	479	c.453C>T	c.(451-453)ttC>ttT	p.F151F		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	151	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCACCCGCTTCCCCCTCACCA	0.617000													10	28					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6166483	6166483	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:6166483G>A	ENST00000262450.3	-	40	5928	c.5829C>T	c.(5827-5829)aaC>aaT	p.N1943N	CHD5_ENST00000378021.1_Intron	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1943					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGGGCATCTGGTTGTAGTTGA	0.672000													5	7					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161324243	161324243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:161324243G>A	ENST00000428797.2	+	11	1541	c.1186G>A	c.(1186-1188)Gaa>Aaa	p.E396K	GABRA1_ENST00000420560.1_Missense_Mutation_p.E396K|GABRA1_ENST00000444819.1_Missense_Mutation_p.E396K|GABRA1_ENST00000437025.2_Missense_Mutation_p.E396K|GABRA1_ENST00000023897.6_Missense_Mutation_p.E396K|GABRA1_ENST00000393943.4_Missense_Mutation_p.E396K	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	396					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TGCAACCATAGAACCTAAAGA	0.478000													25	136					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105990440	105990440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105990440G>A	ENST00000357060.3	-	2	342	c.227C>T	c.(226-228)cCc>cTc	p.P76L	WDR96_ENST00000428666.1_Missense_Mutation_p.P76L|WDR96_ENST00000278064.2_Missense_Mutation_p.P6L|WDR96_ENST00000369719.1_Missense_Mutation_p.P6L|WDR96_ENST00000369720.1_Missense_Mutation_p.P6L	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	76										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AACTTCACAGGGGATGTTAGT	0.393000													32	100					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558075	140558075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140558075C>T	ENST00000239444.2	+	1	705	c.460C>T	c.(460-462)Cct>Tct	p.P154S		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		154	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACTGCGTTTCCTCTGAAGAA	0.438000													45	191					0	0	1	0	0
DAW1	164781	broad.mit.edu	37	2	228786229	228786229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228786229G>A	ENST00000309931.2	+	12	1248	c.1165G>A	c.(1165-1167)Gaa>Aaa	p.E389K	DAW1_ENST00000373666.2_3'UTR|DAW1_ENST00000545118.1_Missense_Mutation_p.E374K	NM_178821.1	NP_849143.1			dynein assembly factor with WDR repeat domains 1																		GCACACTGATGAAATCTTTTC	0.438000													30	88					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537629	55537629	+	Missense_Mutation	SNP	G	G	A	rs141279458	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:55537629G>A	ENST00000220676.1	+	4	1335	c.1187G>A	c.(1186-1188)cGa>cAa	p.R396Q		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	396					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCTATGGAGCGAAGCAGTAAT	0.433000													15	45					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128388858	128388858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:128388858G>A	ENST00000368227.3	-	12	2329	c.1963C>T	c.(1963-1965)Cct>Tct	p.P655S	PTPRK_ENST00000368215.3_Missense_Mutation_p.P655S|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368213.5_Missense_Mutation_p.P655S|PTPRK_ENST00000368207.3_Missense_Mutation_p.P655S|PTPRK_ENST00000368226.4_Missense_Mutation_p.P655S|RP11-103C16.2_ENST00000417390.1_RNA|PTPRK_ENST00000532331.1_Missense_Mutation_p.P655S|PTPRK_ENST00000368210.3_Missense_Mutation_p.P655S			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	655	Fibronectin type-III 4.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TATGTGACAGGAACCTGGTAG	0.522000													25	51					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39091507	39091507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39091507G>A	ENST00000379907.4	+	16	1851	c.1724G>A	c.(1723-1725)cGa>cAa	p.R575Q	ADAM32_ENST00000437682.2_Missense_Mutation_p.R476Q|ADAM32_ENST00000519315.1_Missense_Mutation_p.R469Q	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	575					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.R574Q(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			GCTTTCGTACGAGATTCTGTA	0.393000													4	5					0	0	1	0	0
SLC24A5	283652	broad.mit.edu	37	15	48431226	48431226	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48431226C>A	ENST00000341459.3	+	7	1005	c.932C>A	c.(931-933)tCc>tAc	p.S311Y	SLC24A5_ENST00000449382.2_Missense_Mutation_p.S251Y	NM_205850.2	NP_995322.1	Q71RS6	NCKX5_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	311					response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|skin(1)|upper_aerodigestive_tract(1)	27		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		TGGGTATTATCCCTTCCTATT	0.318000													29	71					2.4375e-19	2.4523e-19	1	1	0
MYOM3	127294	broad.mit.edu	37	1	24432531	24432531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24432531C>T	ENST00000330966.7	-	5	604	c.442G>A	c.(442-444)Gag>Aag	p.E148K	MYOM3_ENST00000374434.3_Missense_Mutation_p.E147K|MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000329601.7_Missense_Mutation_p.E147K			Q5VTT5	MYOM3_HUMAN	myomesin 3	147								p.E147K(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TAGCACAGCTCCCTCAGCTCC	0.642000													12	34					0	0	1	0	0
HPSE	10855	broad.mit.edu	37	4	84255861	84255861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:84255861G>A	ENST00000405413.2	-	2	211	c.75C>T	c.(73-75)tcC>tcT	p.S25S	HPSE_ENST00000311412.5_Silent_p.S25S|HPSE_ENST00000513463.1_Silent_p.S25S|HPSE_ENST00000512196.1_Silent_p.S25S	NM_006665.5	NP_006656.2	Q9Y251	HPSE_HUMAN	heparanase	25					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	20		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	GGGCGCCAGGGGAGAGGGGAC	0.711000													5	3					0	0	1	0	0
STEAP3	55240	broad.mit.edu	37	2	120005392	120005392	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120005392G>A	ENST00000354888.5	+	4	1134	c.630G>A	c.(628-630)ccG>ccA	p.P210P	STEAP3_ENST00000393106.2_Silent_p.P210P|STEAP3_ENST00000409811.1_Silent_p.P210P|STEAP3_ENST00000393108.2_Silent_p.P210P|STEAP3_ENST00000425223.2_Silent_p.P210P|STEAP3_ENST00000450943.2_Silent_p.P210P|STEAP3-AS1_ENST00000454260.1_RNA|STEAP3_ENST00000393110.2_Silent_p.P220P|STEAP3_ENST00000393107.2_Silent_p.P210P	NM_182915.2	NP_878919.2	Q658P3	STEA3_HUMAN	STEAP family member 3, metalloreductase	210					apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding	p.P210P(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	17						GCCTCCTCCCGGCCTGGAAGG	0.657000													16	53					0	0	1	0	0
NECAP1	25977	broad.mit.edu	37	12	8245339	8245339	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8245339C>T	ENST00000339754.5	+	5	529	c.451C>T	c.(451-453)Ctg>Ttg	p.L151L		NM_015509.3	NP_056324.2	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	151					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				cervix(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				Kidney(36;0.0915)		TAAGTTGGATCTGGGCTTCAA	0.408000													16	34					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88769257	88769257	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88769257G>A	ENST00000444431.1	+	0	3857				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										AGGGGCAGACGAAACCCTCAA	0.527000													59	158					0	0	1	0	0
CKS2	1164	broad.mit.edu	37	9	91931305	91931305	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91931305T>C	ENST00000314355.6	+	3	300	c.205T>C	c.(205-207)Ttt>Ctt	p.F69L		NM_001827.1	NP_001818.1	P33552	CKS2_HUMAN	CDC28 protein kinase regulatory subunit 2	69					cell division|cell proliferation|phosphatidylinositol-mediated signaling|regulation of cyclin-dependent protein kinase activity|spindle organization		cyclin-dependent protein kinase regulator activity			kidney(1)|large_intestine(1)	2						TATTCTTCTCTTTAGACGACC	0.289000													3	17					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47559743	47559743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47559743C>T	ENST00000273859.3	+	12	2156	c.1887C>T	c.(1885-1887)ttC>ttT	p.F629F	AC092597.3_ENST00000508081.1_RNA	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	629					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						AAAGTCTTTTCCAGAGATGGT	0.448000													14	51					0	0	1	0	0
MMP25	64386	broad.mit.edu	37	16	3108551	3108551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3108551G>A	ENST00000336577.4	+	9	1535	c.1298G>A	c.(1297-1299)gGc>gAc	p.G433D	RP11-473M20.7_ENST00000572574.1_RNA|RP11-473M20.7_ENST00000572222.1_RNA|RP11-473M20.7_ENST00000572427.1_RNA|RP11-473M20.7_ENST00000576250.1_RNA	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	433	Hemopexin-like 3.				inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						CTGGTCCGCGGCCGGCAGTAC	0.751000													5	10					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	121976336	121976336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:121976336C>T	ENST00000265922.3	-	6	1244	c.783G>A	c.(781-783)caG>caA	p.Q261Q	DBC1_ENST00000373964.2_Silent_p.Q261Q	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		261					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						ACTGGCTGTTCTGGCACAGGT	0.537000													16	71					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127967522	127967522	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:127967522C>T	ENST00000368679.4	-	3	531	c.222G>A	c.(220-222)cgG>cgA	p.R74R	ADAM12_ENST00000368676.4_Silent_p.R74R	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	74					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CTTTGCTTTCCCGTTGTAGTC	0.343000													5	27					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814282	60814282	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60814282C>T	ENST00000544856.2	-	7	1322	c.944G>A	c.(943-945)aGa>aAa	p.R315K	RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.R316K|MARCH10_ENST00000311269.5_Missense_Mutation_p.R316K|MARCH10_ENST00000583600.1_Missense_Mutation_p.R354K|RP11-156L14.1_ENST00000582564.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	316							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						AAATCTACTTCTTTTGTGATG	0.453000													114	311					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53347812	53347812	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:53347812T>C	ENST00000395631.2	-	6	1013	c.797A>G	c.(796-798)gAa>gGa	p.E266G	FERMT2_ENST00000343279.4_Missense_Mutation_p.E266G|FERMT2_ENST00000399304.3_Missense_Mutation_p.E266G|FERMT2_ENST00000341590.3_Missense_Mutation_p.E266G|FERMT2_ENST00000553373.1_Missense_Mutation_p.E266G			Q96AC1	FERM2_HUMAN	fermitin family member 2	266	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					GGCCTCATTTTCCTTCACATC	0.368000													18	62					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27672907	27672907	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27672907C>A	ENST00000260570.3	-	36	4111	c.4008G>T	c.(4006-4008)ctG>ctT	p.L1336L		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1336					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GTCCTACAGCCAGAACGACTT	0.473000													18	55					3.41278e-10	3.42653e-10	1	1	0
SIGLEC11	114132	broad.mit.edu	37	19	50455584	50455584	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50455584G>A	ENST00000447370.2	-	9	1809	c.1719C>T	c.(1717-1719)ctC>ctT	p.L573L	SIGLEC11_ENST00000426971.2_Silent_p.L477L|CTC-326K19.6_ENST00000451973.1_Intron	NM_052884.2	NP_443116.2	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11	573					cell adhesion	integral to membrane	sugar binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(6)|pancreas(1)|prostate(1)|skin(1)	32		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		AACAGAAAGCGAGCAGGGCAG	0.637000													32	107					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126777540	126777540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:126777540C>T	ENST00000373615.4	+	3	1202	c.463C>T	c.(463-465)Cac>Tac	p.H155Y		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	155	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						CACGGGCGACCACTTCGGCAT	0.607000													57	97					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77817742	77817742	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77817742C>T	ENST00000334306.2	-	1	1260	c.1261G>A	c.(1261-1263)Gag>Aag	p.E421K		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	421																	TGCAGCCCCTCTTCAGAAGCC	0.607000													9	154					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248005100	248005100	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248005100G>A	ENST00000355784.2	-	1	154	c.99C>T	c.(97-99)ctC>ctT	p.L33L		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCAGTAGATGAGCAGGAAAA	0.498000													14	38					0	0	1	0	0
IGHV3-49	28423	broad.mit.edu	37	14	107013108	107013108	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107013108C>T	ENST00000390625.2	-	0	266																											CACTCCAGCCCCTTCCCTGGA	0.522000													25	110					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143055978	143055978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143055978C>T	ENST00000409408.1	-	4	2032	c.324G>A	c.(322-324)agG>agA	p.R108R	FAM131B_ENST00000443739.2_Silent_p.R136R|FAM131B_ENST00000409578.1_Silent_p.R124R|FAM131B_ENST00000409346.1_Silent_p.R108R|FAM131B_ENST00000409222.3_Silent_p.R108R			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	108										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					CATCCGTATCCCTGCGCACGG	0.587000													12	38					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120824973	120824973	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:120824973G>A	ENST00000369144.3	-	7	1187	c.1060C>T	c.(1060-1062)Cgc>Tgc	p.R354C	EIF3A_ENST00000541549.1_Missense_Mutation_p.R320C|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	354					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		GTTGCAAGGCGACGCTGTTTT	0.428000													30	99					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153546	5153546	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5153546G>A	ENST00000307388.1	-	1	326	c.327C>T	c.(325-327)ttC>ttT	p.F109F		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAATTGCCTGGAATGAGTGAA	0.453000													13	47					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204587068	204587068	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204587068G>T	ENST00000367175.1	-	1	4265	c.2053C>A	c.(2053-2055)Ccc>Acc	p.P685T	LRRN2_ENST00000367176.3_Missense_Mutation_p.P685T|LRRN2_ENST00000367177.3_Missense_Mutation_p.P685T			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	685					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			AGGACGAGGGGAGCAGACACA	0.617000													39	116					1.66425e-11	1.67142e-11	1	1	0
ESYT1	23344	broad.mit.edu	37	12	56531834	56531834	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56531834C>T	ENST00000394048.5	+	20	2487	c.2223C>T	c.(2221-2223)gtC>gtT	p.V741V	ESYT1_ENST00000541590.1_Silent_p.V751V|ESYT1_ENST00000267113.4_Silent_p.V751V|ESYT1_ENST00000550878.1_3'UTR	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	741						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						TCACCACAGTCTTAAACAGTG	0.468000													22	124					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43626727	43626727	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:43626727T>A	ENST00000332857.6	-	4	1988	c.1960A>T	c.(1960-1962)Aag>Tag	p.K654*		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		AACTTCACCTTCTGTGCCTCC	0.567000													47	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640263	179640263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179640263C>T	ENST00000589042.1	-	28	6552	c.6328G>A	c.(6328-6330)Gaa>Aaa	p.E2110K	TTN_ENST00000342992.6_Missense_Mutation_p.E2110K|TTN_ENST00000360870.5_Missense_Mutation_p.E2110K|TTN_ENST00000460472.2_Missense_Mutation_p.E2064K|TTN_ENST00000342175.6_Missense_Mutation_p.E2064K|TTN_ENST00000359218.5_Missense_Mutation_p.E2064K|TTN_ENST00000591111.1_Missense_Mutation_p.E2110K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1873	Ig-like 10.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTACCATTCACATTCGGGG	0.483000													6	58					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160106098	160106098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160106098G>A	ENST00000361216.3	+	18	2590	c.2501G>A	c.(2500-2502)cGa>cAa	p.R834Q	ATP1A2_ENST00000392233.3_Missense_Mutation_p.R834Q|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	834					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CGGCAGCCACGAAACTCCCAG	0.597000													37	70					0	0	1	0	0
ARMC2	84071	broad.mit.edu	37	6	109249363	109249363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:109249363C>T	ENST00000392644.4	+	11	1591	c.1423C>T	c.(1423-1425)Ccc>Tcc	p.P475S	ARMC2_ENST00000368972.3_Missense_Mutation_p.P310S	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	475							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		CAGTGCCCTTCCCCAGCTCTG	0.438000													19	113					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962862	69962862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69962862G>A	ENST00000305231.7	+	1	670	c.624G>A	c.(622-624)atG>atA	p.M208I	UGT2B7_ENST00000508661.1_Missense_Mutation_p.M208I|UGT2B7_ENST00000509763.1_Intron	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	208					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGACTTTCATGGAGAGGGTAA	0.358000													27	88					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756137	71756137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71756137G>A	ENST00000318442.5	-	2	1677	c.1187C>T	c.(1186-1188)tCc>tTc	p.S396F		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		GTCGCACTCGGAGCAGTTGTA	0.602000													13	47					0	0	1	0	0
C10orf88	80007	broad.mit.edu	37	10	124692119	124692119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124692119G>A	ENST00000481909.1	-	6	1386	c.1162C>T	c.(1162-1164)Ctg>Ttg	p.L388L	C10orf88_ENST00000368891.5_5'UTR	NM_024942.3	NP_079218.2	Q9H8K7	CJ088_HUMAN	chromosome 10 open reading frame 88	388										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)	18		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		TTTTCCATCAGTTCCATATTT	0.308000													11	49					0	0	1	0	0
EFCAB3	146779	broad.mit.edu	37	17	60493656	60493656	+	Missense_Mutation	SNP	G	G	A	rs140338043	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60493656G>A	ENST00000450662.2	+	12	1510	c.1439G>A	c.(1438-1440)aGa>aAa	p.R480K	EFCAB3_ENST00000305286.3_Missense_Mutation_p.R428K	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	428							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			GGAAGAAAAAGAAAACGGAAA	0.333000													33	104					0	0	1	0	0
TMEM161A	54929	broad.mit.edu	37	19	19231957	19231957	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19231957G>A	ENST00000450333.2	-	8	661	c.624C>T	c.(622-624)ttC>ttT	p.F208F	TMEM161A_ENST00000587583.2_Silent_p.F286F|TMEM161A_ENST00000162044.9_Silent_p.F311F	NM_001256766.1	NP_001243695.1	Q9NX61	T161A_HUMAN	transmembrane protein 161A	311					cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			GCCCAGAGTCGAAGGCAGAAT	0.697000													6	21					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121344402	121344402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121344402C>T	ENST00000297848.3	+	41	4952	c.4682C>T	c.(4681-4683)tCc>tTc	p.S1561F	COL14A1_ENST00000247781.3_Missense_Mutation_p.S1466F|COL14A1_ENST00000309791.4_Missense_Mutation_p.S1561F	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1561	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AAGGATGGATCCTCGGGACCT	0.463000													19	43					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196952140	196952140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196952140C>T	ENST00000367414.5	+	2	312	c.256C>T	c.(256-258)Cct>Tct	p.P86S	CFHR5_ENST00000256785.4_Missense_Mutation_p.P62S	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	62	Sushi 2.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						TTTTGTGTCTCCTTCAAAATC	0.393000													33	90					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96080179	96080179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96080179G>A	ENST00000297954.4	+	30	6764	c.6764G>A	c.(6763-6765)aGa>aAa	p.R2255K	WNK2_ENST00000395475.2_Intron|WNK2_ENST00000471076.1_Intron|WNK2_ENST00000427277.2_Intron|WNK2_ENST00000349097.3_Intron|WNK2_ENST00000395477.2_Intron|WNK2_ENST00000356055.3_Intron			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	2255					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						ACCGCCCGGAGAAACCAGGTG	0.682000													9	15					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60711215	60711215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60711215C>T	ENST00000227880.3	-	3	1175	c.942G>A	c.(940-942)gtG>gtA	p.V314V		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	314					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						GCAAGATCTTCACCAGCACCT	0.617000													5	14					0	0	1	0	0
C1RL	51279	broad.mit.edu	37	12	7254675	7254675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7254675G>A	ENST00000545280.1	-	2	96	c.80C>T	c.(79-81)tCg>tTg	p.S27L	C1RL_ENST00000545337.1_Silent_p.F103F|C1RL_ENST00000544702.1_Silent_p.F103F|C1RL_ENST00000266542.4_Silent_p.F103F			Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	0					complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CCGAACCGACGAATGAGATCT	0.607000													53	111					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21221496	21221496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21221496C>T	ENST00000574002.1	-	4	651	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K	ZP2_ENST00000219593.4_Missense_Mutation_p.E57K|ZP2_ENST00000574091.1_Missense_Mutation_p.E57K			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	57					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		ATTTCCCTTTCATCGCAAGTG	0.478000													25	78					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100189522	100189522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100189522G>A	ENST00000241071.6	+	4	877	c.555G>A	c.(553-555)aaG>aaA	p.K185K	FBXO24_ENST00000468962.1_Silent_p.K173K|FBXO24_ENST00000360609.2_Silent_p.K171K|FBXO24_ENST00000465843.1_Silent_p.K171K|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000427939.2_Silent_p.K223K	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	185						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GTGGAGCCAAGGATGTGAGTA	0.552000													20	73					0	0	1	0	0
IFNA10	3446	broad.mit.edu	37	9	21207021	21207021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21207021G>A	ENST00000357374.2	-	1	121	c.76C>T	c.(76-78)Ctg>Ttg	p.L26L		NM_002171.1	NP_002162.1	P01566	IFN10_HUMAN	interferon, alpha 10	26					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|large_intestine(3)|liver(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		GTCTGAGGCAGATCACAGCCT	0.493000													10	87					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43153697	43153697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43153697C>T	ENST00000252050.4	+	4	839	c.755C>T	c.(754-756)cCa>cTa	p.P252L	CUL9_ENST00000372647.2_Missense_Mutation_p.P252L|CUL9_ENST00000354495.3_Missense_Mutation_p.P252L	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	252					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						TTACAGATCCCAGGAAAGCTG	0.507000													19	48					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1248754	1248754	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1248754C>T	ENST00000348261.5	+	6	1031	c.783C>T	c.(781-783)ttC>ttT	p.F261F	CACNA1H_ENST00000565831.1_Silent_p.F261F|CACNA1H_ENST00000358590.4_Silent_p.F261F	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	261					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ACCGCTGCTTCCTGGACAGTG	0.632000													5	22					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	71004250	71004250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:71004250C>T	ENST00000357250.6	-	5	474	c.316G>A	c.(316-318)Gga>Aga	p.G106R	COL9A1_ENST00000370496.3_Missense_Mutation_p.G106R	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	106	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						TCAGGCAGTCCACTGGGATAT	0.388000													47	81					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28802509	28802509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:28802509G>A	ENST00000422425.2	+	23	1578	c.1534G>A	c.(1534-1536)Gaa>Aaa	p.E512K	PLB1_ENST00000327757.5_Missense_Mutation_p.E501K|PLB1_ENST00000329020.6_Missense_Mutation_p.E189K	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	501	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					ACACTTTCAGGAAGACTGGAA	0.423000													46	76					0	0	1	0	0
SLC26A2	1836	broad.mit.edu	37	5	149360587	149360587	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149360587C>T	ENST00000286298.4	+	3	1699	c.1431C>T	c.(1429-1431)tcC>tcT	p.S477S		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	477						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGTTCTATTCCCTTCAAAAAA	0.423000													5	82					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39895211	39895211	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39895211G>A	ENST00000373186.4	-	1	244	c.107C>T	c.(106-108)cCt>cTt	p.P36L	MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000340692.5_Intron|MOCS1_ENST00000425303.2_Missense_Mutation_p.P36L|MOCS1_ENST00000432280.2_Intron|MOCS1_ENST00000373188.2_Intron|MOCS1_ENST00000308559.7_Intron|MOCS1_ENST00000373175.4_Intron	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	32	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGACAGACCAGGGAGGAAGCA	0.652000													5	14					0	0	1	0	0
CNPPD1	27013	broad.mit.edu	37	2	220037701	220037701	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220037701G>A	ENST00000409789.1	-	9	1267	c.840C>T	c.(838-840)ccC>ccT	p.P280P	CNPPD1_ENST00000360507.5_Silent_p.P280P			Q9BV87	CNPD1_HUMAN	cyclin Pas1/PHO80 domain containing 1	280					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	12						AAGGTATGCAGGGCTCCAGGA	0.612000													11	136					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61310721	61310721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61310721G>A	ENST00000341074.5	-	2	206	c.91C>T	c.(91-93)Cct>Tct	p.P31S	SERPINB4_ENST00000356424.6_Missense_Mutation_p.P31S	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4									p.P31T(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						ATGCTGATAGGGGAATAGAAG	0.423000													39	184					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176295655	176295655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176295655C>T	ENST00000329542.4	+	4	804	c.530C>T	c.(529-531)cCt>cTt	p.P177L	UNC5A_ENST00000261961.3_Missense_Mutation_p.P137L	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	177	Ig-like C2-type.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGGGCATCCCTCCAGCCGAG	0.672000													3	6					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54792313	54792313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54792313G>A	ENST00000306858.7	+	4	733	c.617G>A	c.(616-618)cGa>cAa	p.R206Q		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	206										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TAGAATATTCGAGTGCGAACA	0.303000													16	86					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96034781	96034781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:96034781C>T	ENST00000358812.4	+	2	600	c.466C>T	c.(466-468)Cct>Tct	p.P156S	MANEA_ENST00000369293.1_Missense_Mutation_p.P156S	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	156	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		CAGCTTTTATCCTGAATTGGG	0.408000													59	118					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86252923	86252923	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:86252923G>A	ENST00000314673.3	-	14	1542	c.1366C>T	c.(1366-1368)Cct>Tct	p.P456S	SNX14_ENST00000369627.2_Missense_Mutation_p.P456S|SNX14_ENST00000346348.3_Missense_Mutation_p.P412S|SNX14_ENST00000508980.1_5'UTR|SNX14_ENST00000505648.1_Missense_Mutation_p.P404S|SNX14_ENST00000513865.1_Intron	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	456	RGS.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CAGAACATAGGAGTAAATACA	0.323000													21	109					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232704	21232704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21232704C>T	ENST00000233242.1	-	26	7163	c.7036G>A	c.(7036-7038)Gag>Aag	p.E2346K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2346					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCATACCTCTCGATTAACTCA	0.373000													23	90					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107914328	107914328	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:107914328G>A	ENST00000280758.5	+	2	1728	c.1200G>A	c.(1198-1200)ggG>ggA	p.G400G	BTBD11_ENST00000420571.2_Silent_p.G400G|BTBD11_ENST00000490090.2_Silent_p.G400G	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	400						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						ACAAGCCAGGGGAACTGCCCA	0.552000													16	126					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78383099	78383099	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78383099C>T	ENST00000278550.7	-	31	6234	c.5772G>A	c.(5770-5772)tgG>tgA	p.W1924*		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		ATGTGTAGCTCCATGTCTTCC	0.547000													8	23					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99438729	99438729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99438729G>A	ENST00000397899.2	-	7	2338	c.2007C>T	c.(2005-2007)gcC>gcT	p.A669A		NM_207362.2	NP_997245.2			KIAA1211-like																		GCTCCTGGGCGGCTGGGCAGG	0.736000													3	17					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8218758	8218758	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8218758G>A	ENST00000361926.3	+	7	1397	c.1287G>A	c.(1285-1287)gaG>gaA	p.E429E	ARHGEF15_ENST00000421050.1_Silent_p.E429E	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	429	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						TGACGTCCGAGGCTTCCTACC	0.622000													52	106					0	0	1	0	0
SLC26A10	65012	broad.mit.edu	37	12	58014179	58014179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58014179C>T	ENST00000379218.2	+	1	487	c.176C>T	c.(175-177)tCt>tTt	p.S59F	SLC26A10_ENST00000320442.4_Missense_Mutation_p.S59F			Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	59						integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					CTCTACACTTCTTTCTTCCCC	0.557000													159	551					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681068	142681068	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:142681068A>G	ENST00000340634.3	-	1	1110	c.1111T>C	c.(1111-1113)Tcc>Ccc	p.S371P		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	371						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						CAGAATTCGGAGCTGTTTAGG	0.537000													39	126					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142566816	142566816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142566816C>T	ENST00000392957.2	+	16	3160	c.2373C>T	c.(2371-2373)ttC>ttT	p.F791F	EPHB6_ENST00000442129.1_Silent_p.F791F|EPHB6_ENST00000411471.2_Silent_p.F514F	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	791	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GCTTTGCCTTCGTCCATCGCT	0.632000													10	38					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113208245	113208245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113208245G>A	ENST00000401783.2	-	26	4671	c.4335C>T	c.(4333-4335)ctC>ctT	p.L1445L	SVEP1_ENST00000374469.1_Silent_p.L1422L|SVEP1_ENST00000302728.8_Silent_p.L1445L|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1445	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GGAGAGATGGGAGCATGCCAT	0.438000													13	45					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627663	43627663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:43627663C>T	ENST00000332857.6	-	4	1052	c.1024G>A	c.(1024-1026)Gaa>Aaa	p.E342K		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		TCTTTTTCTTCCCAAATGTTG	0.428000													29	126					0	0	1	0	0
RBP5	83758	broad.mit.edu	37	12	7280952	7280952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7280952G>A	ENST00000266560.3	-	2	302	c.136C>T	c.(136-138)Cag>Tag	p.Q46*	RBP5_ENST00000542370.1_Nonsense_Mutation_p.Q46*	NM_031491.2	NP_113679.1	P82980	RET5_HUMAN	retinol binding protein 5, cellular	46						cytoplasm	retinal binding|retinol binding|transporter activity			autonomic_ganglia(1)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)	10					Vitamin A(DB00162)	TGGTTGCCCTGGTGTTCGATC	0.582000													10	71					0	0	1	0	0
TRBV7-8	28590	broad.mit.edu	37	7	142099585	142099585	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142099585G>A	ENST00000390359.3	-	0	255																											TTGTCTAGTTGAGCTTCATTC	0.527000													17	61					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68748346	68748346	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68748346G>A	ENST00000309106.3	-	1	109	c.110C>T	c.(109-111)aCc>aTc	p.T37I		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	37						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCACAGGCAGGTGAACATGGC	0.572000													27	52					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38412636	38412636	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38412636C>T	ENST00000322350.5	+	11	1726	c.1380C>T	c.(1378-1380)atC>atT	p.I460I	EGFLAM_ENST00000397202.2_5'UTR|EGFLAM_ENST00000336740.6_Silent_p.I226I|EGFLAM_ENST00000354891.3_Silent_p.I460I	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	460	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TTGCCATCATCGTAAGTGAGA	0.488000													44	83					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277763	114277763	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114277763C>T	ENST00000357077.4	+	38	8042	c.7989C>T	c.(7987-7989)tcC>tcT	p.S2663S	ANK2_ENST00000264366.6_Silent_p.S2630S|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2630					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGTCTTCCTCCTCAGAAAGTG	0.478000													21	69					0	0	1	0	0
PTGES3L-AARSD1	100885850	broad.mit.edu	37	17	41108281	41108281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:41108281G>A	ENST00000421990.2	-	11	1470	c.1125C>T	c.(1123-1125)atC>atT	p.I375I	PTGES3L-AARSD1_ENST00000409103.1_Silent_p.I284I|PTGES3L-AARSD1_ENST00000360221.4_Silent_p.I314I|PTGES3L-AARSD1_ENST00000409399.1_Silent_p.I375I|AARSD1_ENST00000427569.2_Silent_p.I201I	NM_001136042.2	NP_001129514.2																					CAACGCCCTCGATGTTAACAA	0.547000													14	91					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11583189	11583189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11583189G>A	ENST00000262442.3	+	18	3537	c.3469G>A	c.(3469-3471)Gaa>Aaa	p.E1157K	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1157K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1157	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGCTGTTAAAGAACGGCAGAG	0.408000													48	88					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208133	140208133	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140208133C>T	ENST00000529310.1	+	1	571	c.457C>T	c.(457-459)Cca>Tca	p.P153S	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.P153S	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGTGTTTCCACTGGAGGG	0.483000													38	134					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99439325	99439325	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99439325C>T	ENST00000397899.2	-	7	1742	c.1411G>A	c.(1411-1413)Gga>Aga	p.G471R		NM_207362.2	NP_997245.2			KIAA1211-like																		GTCCCCGCTCCTCTCTCGGGC	0.756000													13	34					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63538522	63538522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:63538522G>A	ENST00000550760.3	+	4	1274	c.1095G>A	c.(1093-1095)ttG>ttA	p.L365L		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.L365F(1)		endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						ATATGGAATTGAGACCTTACA	0.393000													12	22					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57286838	57286838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57286838G>A	ENST00000391708.3	-	12	1344	c.802C>T	c.(802-804)Cct>Tct	p.P268S	ZIM2_ENST00000593711.1_Missense_Mutation_p.P268S|ZIM2_ENST00000601070.1_Missense_Mutation_p.P268S|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000599935.1_Missense_Mutation_p.P268S|ZIM2_ENST00000221722.5_Missense_Mutation_p.P268S	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		ATTGTTATAGGAGTCAAAAGT	0.443000													29	92					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103307750	103307750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:103307750G>A	ENST00000520539.1	-	30	4429	c.3823C>T	c.(3823-3825)Ctc>Ttc	p.L1275F	UBR5_ENST00000220959.4_Missense_Mutation_p.L1275F|UBR5_ENST00000521922.1_Missense_Mutation_p.L1269F	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1275					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AATAGTAAGAGGTGCTCTCCC	0.473000													37	74					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750008	142750008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142750008C>T	ENST00000418316.1	+	1	592	c.571C>T	c.(571-573)Cgc>Tgc	p.R191C		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	191					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					CTCTGACACTCGCCTGTTGGA	0.512000													59	164					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41385135	41385135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41385135G>A	ENST00000400454.1	-	33	6342	c.5865C>T	c.(5863-5865)tcC>tcT	p.S1955S		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1955				HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTCTCGTGGAGGAGGCGGAGG	0.637000													23	13					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71395335	71395335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:71395335G>A	ENST00000392650.3	-	22	3065	c.3065C>T	c.(3064-3066)tCc>tTc	p.S1022F	SDK2_ENST00000388726.3_Missense_Mutation_p.S1022F	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1022	Fibronectin type-III 5.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GCGGGAGATGGAGGTTTTCCC	0.637000													15	24					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66929360	66929360	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:66929360C>T	ENST00000269080.2	-	5	656	c.519G>A	c.(517-519)tgG>tgA	p.W173*	ABCA8_ENST00000586539.1_Nonsense_Mutation_p.W173*|ABCA8_ENST00000430352.2_Nonsense_Mutation_p.W173*	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	173						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					AACCTTCCTTCCAAAATACTG	0.303000													49	143					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150842658	150842658	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150842658G>A	ENST00000370357.4	+	15	2420	c.2175_splice	c.e15+1	p.Q725_splice		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	725						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CCTACCATCAGGTATGGGACA	0.562000													11	65					0	0	1	0	0
MRPS10	55173	broad.mit.edu	37	6	42179636	42179636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42179636G>A	ENST00000053468.3	-	4	221	c.206C>T	c.(205-207)cCa>cTa	p.P69L		NM_018141.3	NP_060611.2	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	69					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|lung(1)	2	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			TAATATGTCTGGTTCATCAGA	0.343000													6	87					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121997	50121997	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50121997G>A	ENST00000374160.3	-	1	280	c.204C>T	c.(202-204)tcC>tcT	p.S68S	RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Silent_p.S68S|WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	68						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						ACTTGGAGATGGAGTCAGGGA	0.532000													11	43					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30033484	30033484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:30033484G>A	ENST00000328224.6	-	2	1975	c.742C>T	c.(742-744)Ccc>Tcc	p.P248S		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	248						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						ATATCAAAGGGGACATTGACT	0.488000													8	137					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176824006	176824006	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176824006C>T	ENST00000324417.5	+	12	1438	c.1347C>T	c.(1345-1347)atC>atT	p.I449I	SLC34A1_ENST00000513614.1_3'UTR	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	449					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTCCAACATCGGCACCACCA	0.652000													16	42					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433089	104433089	+	Silent	SNP	G	G	A	rs143230604	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104433089G>A	ENST00000361820.3	-	3	2205	c.1605C>T	c.(1603-1605)ggC>ggT	p.G535G		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	535					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CAGGGCACAAGCCTTCATCAT	0.473000													34	55					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96702058	96702058	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96702058G>A	ENST00000260682.6	+	3	453	c.441G>A	c.(439-441)gaG>gaA	p.E147E	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	147					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GTGTTCAAGAGGAAGCCCGCT	0.502000													29	150					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97137245	97137245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:97137245G>A	ENST00000524981.3	+	20	2638	c.2638G>A	c.(2638-2640)Gac>Aac	p.D880N				Q6ZTY8	CL063_HUMAN		854										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						AAGCGCAGGGGACACGGAACT	0.413000													34	76					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28576899	28576899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28576899C>T	ENST00000434452.1	-	15	2505	c.2351G>A	c.(2350-2352)gGa>gAa	p.G784E	DSC3_ENST00000360428.4_Missense_Mutation_p.G784E	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	784					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding	p.G784E(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CTGGTTTCCTCCTTTCATCAT	0.498000													21	47					0	0	1	0	0
CMTM5	116173	broad.mit.edu	37	14	23846557	23846557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23846557C>T	ENST00000359320.3	+	1	541	c.97C>T	c.(97-99)Cac>Tac	p.H33Y	CMTM5_ENST00000382809.2_Missense_Mutation_p.H33Y|CMTM5_ENST00000397227.3_Missense_Mutation_p.H33Y|CMTM5_ENST00000555731.1_Missense_Mutation_p.H33Y|CMTM5_ENST00000339180.4_Missense_Mutation_p.H33Y|CMTM5_ENST00000342473.4_Missense_Mutation_p.H33Y	NM_138460.2	NP_612469.1	Q96DZ9	CKLF5_HUMAN	CKLF-like MARVEL transmembrane domain containing 5	33	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	8	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		CCTCACCTCCCACAAGGGCAT	0.647000													17	69					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807501	20807501	+	Silent	SNP	C	C	T	rs111500900		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:20807501C>T	ENST00000601440.1	-	4	1328	c.1182G>A	c.(1180-1182)gaG>gaA	p.E394E	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TGTAGGGTTTCTCTCCAGTAT	0.393000													25	85					0	0	1	0	0
B3GNT6	192134	broad.mit.edu	37	11	76750727	76750727	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76750727G>A	ENST00000421061.1	+	2	83		c.e2-1		B3GNT6_ENST00000533140.1_Silent_p.Q44Q|B3GNT6_ENST00000354301.5_Silent_p.Q44Q			Q6ZMB0	B3GN6_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)						O-glycan processing, core 3	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)|kidney(2)|lung(4)|prostate(1)	8						GGTCCCCGCAGGAGGAGACGC	0.716000											OREG0021252	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	25					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57013055	57013055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:57013055C>T	ENST00000370706.4	+	10	2416	c.2172C>T	c.(2170-2172)tgC>tgT	p.C724C	RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Silent_p.C724C|RP11-203B9.4_ENST00000589549.1_RNA|ZNF451_ENST00000491832.2_Silent_p.C724C|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	724					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CTTGTGGTTGCCGTGAGAGTT	0.358000													10	37					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102495982	102495982	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102495982G>A	ENST00000260228.2	-	1	81	c.69C>T	c.(67-69)gcC>gcT	p.A23A	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	23					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CTAGGGAGGGGGCTGCAGTGG	0.532000													11	73					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181386	140181386	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140181386C>T	ENST00000522353.2	+	1	604	c.604C>T	c.(604-606)Cga>Tga	p.R202*	PCDHA3_ENST00000532566.2_Nonsense_Mutation_p.R202*|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATTTAAATCGAGAGGACAC	0.363000													12	109					0	0	1	0	0
CASP4	837	broad.mit.edu	37	11	104817824	104817824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:104817824C>T	ENST00000444739.2	-	7	1931	c.1021G>A	c.(1021-1023)Gaa>Aaa	p.E341K	CASP4_ENST00000393150.3_Missense_Mutation_p.E285K	NM_001225.3	NP_001216.1	P49662	CASP4_HUMAN	caspase 4, apoptosis-related cysteine peptidase	341					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(2)	23		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		CGAAATACTTCCTCTAGGTGG	0.383000													44	124					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55136144	55136144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55136144G>A	ENST00000314706.3	+	1	785	c.785G>A	c.(784-786)cGa>cAa	p.R262Q		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						GAAGGGAAACGAAAAGCTTTC	0.438000													56	123					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156845925	156845925	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156845925G>A	ENST00000368196.3	+	12	1657	c.1537G>A	c.(1537-1539)Ggc>Agc	p.G513S	NTRK1_ENST00000358660.3_Missense_Mutation_p.G516S|NTRK1_ENST00000392302.2_Missense_Mutation_p.G483S|NTRK1_ENST00000524377.1_Missense_Mutation_p.G519S	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	519	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GCTGGGGGAGGGCGCCTTTGG	0.637000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			9	92					0	0	1	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148715267	148715267	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:148715267G>A	ENST00000296721.4	+	18	2363	c.2265G>A	c.(2263-2265)agG>agA	p.R755R	AFAP1L1_ENST00000515000.1_Intron	NM_001146337.1|NM_152406.2	NP_001139809.1|NP_689619.1	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	755							protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCAAGGAAGGGTGCTACAGA	0.488000													39	111					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234749363	234749363	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234749363G>A	ENST00000411486.2	-	8	2128	c.2063C>T	c.(2062-2064)cCc>cTc	p.P688L	HJURP_ENST00000432087.1_Missense_Mutation_p.P634L|HJURP_ENST00000441687.1_Missense_Mutation_p.P603L	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	688					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		GGAGCCCTGGGGTTCTGATAG	0.592000													29	100					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151916	158151916	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158151916C>T	ENST00000368171.3	+	4	922	c.423C>T	c.(421-423)atC>atT	p.I141I		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	141					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					GAAAAGATATCCTGAGTTTCC	0.517000													109	185					0	0	1	0	0
OSBPL6	114880	broad.mit.edu	37	2	179214050	179214050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179214050G>A	ENST00000190611.4	+	12	1463	c.1087G>A	c.(1087-1089)Gac>Aac	p.D363N	OSBPL6_ENST00000409045.3_Missense_Mutation_p.D332N|OSBPL6_ENST00000409631.1_Missense_Mutation_p.D363N|OSBPL6_ENST00000359685.3_Missense_Mutation_p.D363N|OSBPL6_ENST00000392505.2_Missense_Mutation_p.D388N|OSBPL6_ENST00000357080.4_Missense_Mutation_p.D332N|OSBPL6_ENST00000315022.2_Missense_Mutation_p.D367N	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	363					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CCACCTCACTGACCCTCTGGA	0.438000													70	171					0	0	1	0	0
ADCY3	109	broad.mit.edu	37	2	25057715	25057715	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:25057715C>T	ENST00000260600.5	-	9	2604	c.1753G>A	c.(1753-1755)Gag>Aag	p.E585K	ADCY3_ENST00000405392.1_Missense_Mutation_p.E218K	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	585					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TGGTTGAGCTCGTGCTCATCT	0.662000													6	22					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164589	26164589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26164589G>A	ENST00000335473.7	+	4	956	c.706G>A	c.(706-708)Gag>Aag	p.E236K	MYO18B_ENST00000536101.1_Missense_Mutation_p.E236K|MYO18B_ENST00000407587.2_Missense_Mutation_p.E236K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	236						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AAAAGGCGAGGAGGGTCAAAG	0.627000													7	11					0	0	1	0	0
FOXR2	139628	broad.mit.edu	37	X	55650144	55650144	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:55650144G>A	ENST00000339140.3	+	0	312					NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2						embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						CTCCAGTAAAGATGGACTTAA	0.428000													5	32					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25005323	25005323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25005323C>T	ENST00000382114.4	-	8	1573	c.1388G>A	c.(1387-1389)gGg>gAg	p.G463E		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	463						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				GGTCATGGCCCCCCGGGATGG	0.507000													53	186					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149046	34149046	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34149046C>T	ENST00000346193.3	-	1	1401	c.1350G>A	c.(1348-1350)aaG>aaA	p.K450K		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	450										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						CCTTAGTTTTCTTCACCCGGG	0.552000													26	20					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94481369	94481369	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94481369G>A	ENST00000370225.3	-	37	5324	c.5238C>T	c.(5236-5238)ttC>ttT	p.F1746F	ABCA4_ENST00000536513.1_Silent_p.F16F	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1746					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GAAACCCGATGAAGATGCCCA	0.517000													6	27					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75601331	75601331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:75601331C>T	ENST00000549446.1	-	2	1113	c.433G>A	c.(433-435)Gag>Aag	p.E145K	KCNC2_ENST00000298972.1_Missense_Mutation_p.E145K|KCNC2_ENST00000341669.3_Missense_Mutation_p.E145K|KCNC2_ENST00000548513.1_Missense_Mutation_p.E145K|KCNC2_ENST00000393288.2_Missense_Mutation_p.E145K|KCNC2_ENST00000540018.1_Missense_Mutation_p.E145K|KCNC2_ENST00000550433.1_Missense_Mutation_p.E145K|KCNC2_ENST00000350228.2_Missense_Mutation_p.E145K	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	145					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						ACGTCGGTCTCGTCGATGCCC	0.667000													16	38					0	0	1	0	0
NUCB2	4925	broad.mit.edu	37	11	17332408	17332408	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17332408C>A	ENST00000529010.1	+	7	739	c.520C>A	c.(520-522)Cat>Aat	p.H174N	NUCB2_ENST00000458064.2_Missense_Mutation_p.H174N|NUCB2_ENST00000323688.6_Missense_Mutation_p.H174N	NM_005013.2	NP_005004.1	P80303	NUCB2_HUMAN	nucleobindin 2	174						cytosol|ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|plasma membrane	calcium ion binding|DNA binding			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						CAAGACTCGTCATGAAGAATT	0.279000													47	106					1.21353e-23	1.22141e-23	1	1	0
PLA2G3	50487	broad.mit.edu	37	22	31533948	31533948	+	Missense_Mutation	SNP	G	G	A	rs145614024		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31533948G>A	ENST00000215885.3	-	4	1066	c.814C>T	c.(814-816)Cgc>Tgc	p.R272C		NM_015715.3	NP_056530.2	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III	272	Phospholipase A2-like.				cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						GGCTGCAGGCGAGCGAGGGGC	0.647000													19	59					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353831	77353831	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:77353831C>T	ENST00000282849.5	-	16	2865	c.2447G>A	c.(2446-2448)gGg>gAg	p.G816E		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	816	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AAACGTGGTCCCAGCGAAGGG	0.572000													12	82					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130501160	130501160	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130501160C>T	ENST00000314830.8	-	12	2561	c.2448G>A	c.(2446-2448)acG>acA	p.T816T	SH2D3C_ENST00000429553.1_Silent_p.T462T|SH2D3C_ENST00000373274.3_Silent_p.T656T|SH2D3C_ENST00000420366.1_Silent_p.T658T|SH2D3C_ENST00000373277.4_Silent_p.T659T|SH2D3C_ENST00000373276.3_Silent_p.T748T	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	816	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCTGGAACTCCGTGCTGAACA	0.647000													4	9					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36500359	36500359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36500359C>T	ENST00000405275.2	+	17	1798	c.1555C>T	c.(1555-1557)Ccg>Tcg	p.P519S	CTNNBL1_ENST00000373473.1_Missense_Mutation_p.P359S|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.P546S|CTNNBL1_ENST00000473857.1_3'UTR|CTNNBL1_ENST00000373469.1_Missense_Mutation_p.P294S			Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	546					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				CGGCCGGAGCCCGGAGTTCCG	0.597000													17	69					0	0	1	0	0
RTBDN	83546	broad.mit.edu	37	19	12939478	12939478	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12939478G>A	ENST00000589272.1	-	5	783	c.454C>T	c.(454-456)Cag>Tag	p.Q152*	RTBDN_ENST00000592204.1_Nonsense_Mutation_p.Q130*|RTBDN_ENST00000458671.2_Nonsense_Mutation_p.Q120*|RTBDN_ENST00000322912.5_Nonsense_Mutation_p.Q152*|RTBDN_ENST00000393233.2_Silent_p.A78A|CTD-2265O21.3_ENST00000588469.1_RNA			Q9BSG5	RTBDN_HUMAN	retbindin	120						extracellular region				kidney(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12						TACCAGGCCTGGCAGAGCTCC	0.652000													9	36					0	0	1	0	0
SCN2B	6327	broad.mit.edu	37	11	118039326	118039326	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118039326C>T	ENST00000278947.5	-	2	452	c.211G>A	c.(211-213)Gag>Aag	p.E71K		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	71	Ig-like C2-type.				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		TTGTTGCACTCCTGGTAAGTC	0.597000													60	150					0	0	1	0	0
MSMB	4477	broad.mit.edu	37	10	51556768	51556768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:51556768G>A	ENST00000358559.2	+	3	214	c.127G>A	c.(127-129)Gga>Aga	p.G43R	MSMB_ENST00000298239.6_Intron|MSMB_ENST00000474170.1_3'UTR	NM_002443.3	NP_002434.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	43						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						GGATCTCAAAGGAAACAAACA	0.428000													19	48					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40854284	40854284	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:40854284C>T	ENST00000254691.5	+	3	3049	c.2850C>T	c.(2848-2850)tcC>tcT	p.S950S	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	950					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						CCAACCCATCCACAGTCAAAC	0.498000													88	210					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039197	11039197	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11039197G>A	ENST00000470054.1	-	0	1006									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGATTCAATGACAAATTTTG	0.428000													18	419					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219499293	219499293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219499293G>A	ENST00000450993.2	+	13	2175	c.1836G>A	c.(1834-1836)caG>caA	p.Q612Q	PLCD4_ENST00000432688.1_Silent_p.Q644Q|PLCD4_ENST00000417849.1_Silent_p.Q612Q	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	612					intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GTGATATCCAGAGTTCTTTCC	0.498000													72	190					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98378568	98378568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98378568G>A	ENST00000186436.5	-	36	5047	c.4819C>T	c.(4819-4821)Ccc>Tcc	p.P1607S		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1607						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						GCAGCTGGGGGAGACGGGGAA	0.557000													17	36					0	0	1	0	0
PPCS	79717	broad.mit.edu	37	1	42925368	42925368	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42925368C>T	ENST00000372561.3	+	3	714	c.707C>T	c.(706-708)cCc>cTc	p.P236L	PPCS_ENST00000372562.1_Missense_Mutation_p.P63L|PPCS_ENST00000472013.1_3'UTR|PPCS_ENST00000455780.1_Missense_Mutation_p.P63L|PPCS_ENST00000372556.3_3'UTR	NM_024664.2	NP_078940.2	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase	236					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|skin(3)	12	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAGACTGACCCCGCCATTGTA	0.403000													35	116					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542542	133542542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133542542C>T	ENST00000409261.1	-	14	2215	c.1842G>A	c.(1840-1842)gtG>gtA	p.V614V	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Silent_p.V614V	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	614							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CCAGGTTCTCCACGGACTTAT	0.483000													19	44					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50683792	50683792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:50683792G>A	ENST00000442544.2	+	8	1944	c.1328G>A	c.(1327-1329)cGa>cAa	p.R443Q	DCC_ENST00000412726.1_Missense_Mutation_p.R291Q|DCC_ENST00000581580.1_Missense_Mutation_p.R98Q	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	443	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.R443Q(2)		NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTTTCCAGCCGATTTGTCCGT	0.527000													44	170					0	0	1	0	0
RGS14	10636	broad.mit.edu	37	5	176795904	176795904	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176795904C>T	ENST00000408923.3	+	9	1224	c.1036C>T	c.(1036-1038)Ctg>Ttg	p.L346L		NM_006480.4	NP_006471.2	O43566	RGS14_HUMAN	regulator of G-protein signaling 14	346	Necessary for interaction with RABGEF1 (By similarity).|RBD 1.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(3)|upper_aerodigestive_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAAGGTCTACCTGGTGGGCAA	0.567000											OREG0017086	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	30					0	0	1	0	0
KDM2A	22992	broad.mit.edu	37	11	67017891	67017891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67017891C>T	ENST00000529006.2	+	17	2836	c.2390C>T	c.(2389-2391)tCg>tTg	p.S797L	KDM2A_ENST00000308783.5_Missense_Mutation_p.S255L|KDM2A_ENST00000530342.1_Missense_Mutation_p.S358L|KDM2A_ENST00000526258.1_3'UTR|KDM2A_ENST00000398645.2_Intron	NM_012308.2	NP_036440.1	Q9Y2K7	KDM2A_HUMAN	lysine (K)-specific demethylase 2A	797					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|urinary_tract(2)	36						ATCCGGGGATCGTACCTCACT	0.587000													28	75					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104176567	104176567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104176567G>A	ENST00000020673.5	-	2	755	c.229C>T	c.(229-231)Cgt>Tgt	p.R77C	PSD_ENST00000492902.2_5'UTR|PSD_ENST00000406432.1_Missense_Mutation_p.R77C	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	77	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGAGCAACACGGGGTGAGGGG	0.672000													32	68					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64507629	64507629	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64507629G>A	ENST00000377494.1	-	5	1300	c.378C>T	c.(376-378)acC>acT	p.T126T	RASGRP2_ENST00000354024.3_Silent_p.T126T|RASGRP2_ENST00000377497.3_Silent_p.T126T|RASGRP2_ENST00000394432.3_Silent_p.T126T			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	126	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TCCACTTGTAGGTAGGGCTGG	0.597000													25	67					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38783393	38783393	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38783393G>A	ENST00000359357.3	+	24	3086	c.2832G>A	c.(2830-2832)gtG>gtA	p.V944V	DNAH8_ENST00000449981.2_Silent_p.V1161V|DNAH8_ENST00000441566.1_Silent_p.V944V					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTACTGACGTGACCCATCAAA	0.453000													12	49					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111156421	111156421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111156421C>T	ENST00000280325.4	+	4	500	c.353C>T	c.(352-354)cCt>cTt	p.P118L		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	118										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CTCAGCCAGCCTGACCCTGTG	0.597000													37	60					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143080913	143080913	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:143080913G>A	ENST00000367603.2	-	9	7254	c.6512C>T	c.(6511-6513)cCt>cTt	p.P2171L	HIVEP2_ENST00000012134.2_Missense_Mutation_p.P2171L|HIVEP2_ENST00000367604.1_Missense_Mutation_p.P2171L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	2171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ACTTACAGGAGGCCCCAATAC	0.433000													20	65					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48734526	48734526	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48734526C>T	ENST00000285238.8	+	4	548	c.468C>T	c.(466-468)atC>atT	p.I156I	ABCC3_ENST00000427699.1_Silent_p.I156I	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	156					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GCTCCAAGATCCTTTTAGCCA	0.567000													47	118					0	0	1	0	0
RECQL	5965	broad.mit.edu	37	12	21652496	21652496	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21652496G>A	ENST00000444129.2	-	2	477	c.9C>T	c.(7-9)tcC>tcT	p.S3S	RECQL_ENST00000421138.2_Silent_p.S3S	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	3					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						AACCTGAAACGGACGCCATTC	0.264000								Other identified genes with known or suspected DNA repair function					25	77					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114823558	114823558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114823558C>T	ENST00000315366.7	-	2	2538	c.1672G>A	c.(1672-1674)Gaa>Aaa	p.E558K	ARSJ_ENST00000541197.1_Missense_Mutation_p.E558K	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	558						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		ttcttggtttcctcttTATAC	0.448000													11	25					0	0	1	0	0
PRELP	5549	broad.mit.edu	37	1	203452401	203452401	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203452401C>T	ENST00000343110.2	+	2	216	c.89C>T	c.(88-90)aCt>aTt	p.T30I		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	30					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			AGACCCGGGACTGGGCCCGGG	0.647000													27	92					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21991358	21991358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21991358G>A	ENST00000327430.3	-	2	2798	c.2504C>T	c.(2503-2505)tCt>tTt	p.S835F	SALL2_ENST00000450879.2_Missense_Mutation_p.S698F|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	835							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		TGGCAAAGAAGACTGTTGAGT	0.567000													12	69					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282579	69282579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69282579G>A	ENST00000338352.2	+	1	239	c.205G>A	c.(205-207)Gac>Aac	p.D69N		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	69										autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						GTTCCAAGACGACAGTAGCAT	0.547000													12	8					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7050889	7050889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:7050889C>T	ENST00000389658.3	-	4	485	c.392G>A	c.(391-393)cGa>cAa	p.R131Q		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	131	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTTCCAGGTCGAGGGGCATT	0.463000													17	40					0	0	1	0	0
ADAL	161823	broad.mit.edu	37	15	43641199	43641199	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43641199C>T	ENST00000422466.2	+	11	1302	c.728C>T	c.(727-729)tCc>tTc	p.S243F	ADAL_ENST00000562188.1_Missense_Mutation_p.S243F|ADAL_ENST00000389651.4_Missense_Mutation_p.S243F|ADAL_ENST00000428046.3_Missense_Mutation_p.S216F			Q6DHV7	ADAL_HUMAN	adenosine deaminase-like	243					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding			endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)	7		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GAGGGAGGATCCCTGGATCTG	0.488000													31	61					0	0	1	0	0
P2RY12	64805	broad.mit.edu	37	3	151056222	151056222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151056222G>A	ENST00000302632.3	-	3	711	c.412C>T	c.(412-414)Ctc>Ttc	p.L138F	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000491549.1_Intron|MED12L_ENST00000474524.1_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	138					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	GCCCCCAAGAGATTTTTGGGG	0.423000													34	81					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124390561	124390561	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124390561G>A	ENST00000368909.3	+	46	5829	c.5723G>A	c.(5722-5724)gGg>gAg	p.G1908E	DMBT1_ENST00000330163.4_Missense_Mutation_p.G1280E|DMBT1_ENST00000368955.3_Missense_Mutation_p.G1898E|DMBT1_ENST00000359586.6_Missense_Mutation_p.G628E|DMBT1_ENST00000368956.2_Missense_Mutation_p.G1280E|DMBT1_ENST00000344338.3_Missense_Mutation_p.G1898E|DMBT1_ENST00000338354.3_Missense_Mutation_p.G1908E	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1908	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGCACCTGGGGGACAGTTTGT	0.478000													17	39					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37414539	37414539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37414539C>T	ENST00000535679.1	-	2	270	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K	SULT6B1_ENST00000379149.2_Missense_Mutation_p.E91K|SULT6B1_ENST00000260637.3_Missense_Mutation_p.E53K|SULT6B1_ENST00000407963.1_Missense_Mutation_p.E53K			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	91						cytoplasm	sulfotransferase activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				ACTGGGAATTCTGGATATTTA	0.323000													7	62					0	0	1	0	0
KBTBD11	9920	broad.mit.edu	37	8	1950790	1950790	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:1950790G>A	ENST00000320248.3	+	2	2398	c.1432G>A	c.(1432-1434)Gac>Aac	p.D478N		NM_014867.2	NP_055682.1	O94819	KBTBB_HUMAN	kelch repeat and BTB (POZ) domain containing 11	478										lung(1)|pancreas(1)	2		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.72e-05)|READ - Rectum adenocarcinoma(644;0.0929)|COAD - Colon adenocarcinoma(149;0.134)		CCCGCGGCGCGACGAGTGGCA	0.682000													5	20					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37346438	37346438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:37346438G>A	ENST00000373091.3	-	3	363	c.347C>T	c.(346-348)tCc>tTc	p.S116F	GRIK3_ENST00000373093.4_Missense_Mutation_p.S116F	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	116					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	ATTGGTGCAGGAGCCCTGTGA	0.632000													13	20					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6440044	6440044	+	Silent	SNP	C	C	T	rs104895272		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6440044C>T	ENST00000162749.2	-	6	899	c.600G>A	c.(598-600)gaG>gaA	p.E200E	TNFRSF1A_ENST00000540022.1_Silent_p.E157E	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	200					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						CCTTAACATTCTCAATCTGGG	0.552000													13	41					0	0	1	0	0
LETM2	137994	broad.mit.edu	37	8	38258410	38258410	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:38258410C>T	ENST00000379957.4	+	6	950	c.823C>T	c.(823-825)Cgc>Tgc	p.R275C	LETM2_ENST00000527710.1_Missense_Mutation_p.R61C|LETM2_ENST00000524874.1_Missense_Mutation_p.R227C|LETM2_ENST00000528827.1_3'UTR|RP11-350N15.3_ENST00000533301.1_RNA|LETM2_ENST00000297720.5_Missense_Mutation_p.R180C|LETM2_ENST00000523983.2_Missense_Mutation_p.R228C	NM_001199659.1	NP_001186588.1	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane protein 2	275	LETM1.					integral to membrane|mitochondrial inner membrane				NS(1)|large_intestine(1)|lung(3)|prostate(2)	7	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			GGAGATAGTTCGCTTCTCCAA	0.463000													61	107					0	0	1	0	0
HSD17B2	3294	broad.mit.edu	37	16	82131753	82131753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82131753G>A	ENST00000199936.4	+	5	1069	c.876G>A	c.(874-876)caG>caA	p.Q292Q	RP11-510J16.5_ENST00000567021.1_RNA	NM_002153.2	NP_002144.1	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	292					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10					NADH(DB00157)	CTGAGGTACAGGAAGACTACG	0.537000													25	79					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681119	100681119	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100681119C>T	ENST00000306151.4	+	3	6486	c.6422C>T	c.(6421-6423)tCa>tTa	p.S2141L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2141	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGTCAGTTCATCTCCTATA	0.502000													117	368					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139113660	139113660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139113660G>A	ENST00000358701.5	-	6	840	c.803C>T	c.(802-804)tCg>tTg	p.S268L		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	268					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		CAATCCATGCGACCCATTTGG	0.557000													27	58					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49444380	49444380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49444380G>A	ENST00000301067.7	-	11	2990	c.2991C>T	c.(2989-2991)ccC>ccT	p.P997P		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGATCATAGGGGGGACAGGCT	0.617000													10	31					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294729	124294729	+	Silent	SNP	G	G	A	rs151066825		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124294729G>A	ENST00000356130.3	-	1	60	c.39C>T	c.(37-39)atC>atT	p.I13I		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		ATCCCACAAGGATAAACTCAG	0.488000													13	51					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76449531	76449531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76449531C>T	ENST00000389840.5	-	65	10505	c.10381G>A	c.(10381-10383)Gag>Aag	p.E3461K	DNAH17_ENST00000585328.1_Missense_Mutation_p.E3470K|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ATGGCCTGCTCGATGACATCC	0.607000													7	42					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43247047	43247047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43247047G>A	ENST00000255226.6	+	13	2521	c.1705G>A	c.(1705-1707)Gag>Aag	p.E569K	SLC14A2_ENST00000586448.1_Missense_Mutation_p.E569K|SLC14A2_ENST00000589658.1_Missense_Mutation_p.E46K	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	569						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGAGTGTGGAGAGGGACTTAA	0.507000													5	37					0	0	1	0	0
BPIFA1	51297	broad.mit.edu	37	20	31825928	31825928	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31825928C>T	ENST00000354297.4	+	3	299	c.228C>T	c.(226-228)atC>atT	p.I76I	BPIFA1_ENST00000375422.2_Silent_p.I76I|BPIFA1_ENST00000375413.4_Silent_p.I76I	NM_130852.2	NP_570913.1	Q9NP55	PLUNC_HUMAN	BPI fold containing family A, member 1	76					innate immune response	extracellular region	lipid binding										TCCTGGACATCCTGAAGCCTG	0.562000													28	75					0	0	1	0	0
KITLG	4254	broad.mit.edu	37	12	88926235	88926235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:88926235G>A	ENST00000347404.5	-	3	747	c.175C>T	c.(175-177)Ccc>Tcc	p.P59S	KITLG_ENST00000357116.4_Intron|KITLG_ENST00000228280.5_Missense_Mutation_p.P59S|KITLG_ENST00000378535.4_5'UTR	NM_003994.5	NP_003985.2	P21583	SCF_HUMAN	KIT ligand	59					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)	9						TCCATCCCGGGGACATATTTG	0.328000									Testicular Cancer, Familial Clustering of				39	116					0	0	1	0	0
SLC5A3	6526	broad.mit.edu	37	21	35467931	35467931	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:35467931C>T	ENST00000381151.3	+	2	946	c.434C>T	c.(433-435)tCg>tTg	p.S145L	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	145						integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						GATCTGTATTCGGGTGCCCTT	0.468000													49	238					0	0	1	0	0
HAP1	9001	broad.mit.edu	37	17	39883338	39883338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39883338C>T	ENST00000393939.2	-	8	1268	c.1259G>A	c.(1258-1260)aGg>aAg	p.R420K	HAP1_ENST00000347901.4_Missense_Mutation_p.R445K|HAP1_ENST00000310778.5_Missense_Mutation_p.R497K|HAP1_ENST00000341193.5_Missense_Mutation_p.R428K|JUP_ENST00000540235.1_Intron			P54257	HAP1_HUMAN	huntingtin-associated protein 1	422	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TGAGATCATCCTCCTTAGAGA	0.572000													6	7					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158974353	158974353	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158974353C>T	ENST00000605860.1	+	7	574	c.528C>T	c.(526-528)ccC>ccT	p.P176P	UPP2_ENST00000409859.4_Silent_p.P176P|UPP2_ENST00000005756.4_Silent_p.P119P|UPP2_ENST00000460456.1_Intron			O95045	UPP2_HUMAN	uridine phosphorylase 2	119					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						TGGGCATCCCCTCCATTTCTA	0.413000													12	105					0	0	1	0	0
RASAL3	64926	broad.mit.edu	37	19	15562664	15562664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15562664C>T	ENST00000343625.6	-	18	3058	c.2978G>A	c.(2977-2979)gGg>gAg	p.G993E		NM_022904.1	NP_075055.1	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	993					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|skin(1)	18						ACTCCAAGACCCCCGCGTCCT	0.607000													30	57					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111097299	111097299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:111097299G>A	ENST00000262839.2	-	4	1854	c.936C>T	c.(934-936)gcC>gcT	p.A312A		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	312					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ACCACAGGGTGGCAAGCAACT	0.488000													9	5					0	0	1	0	0
CDRT1	374286	broad.mit.edu	37	17	15492462	15492462	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:15492462G>A	ENST00000395906.3	-	12	2085	c.2086C>T	c.(2086-2088)Cag>Tag	p.Q696*	CDRT1_ENST00000583965.1_3'UTR|CDRT1_ENST00000354433.3_Nonsense_Mutation_p.Q196*|RP11-385D13.1_ENST00000455584.2_Intron	NM_006382.3	NP_006373.2	O95170	CDRT1_HUMAN	CMT1A duplicated region transcript 1	696										endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|stomach(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		TTTCCTCCCTGAGCTGTAGCA	0.517000													37	48					0	0	1	0	0
ST8SIA2	8128	broad.mit.edu	37	15	92988086	92988086	+	Missense_Mutation	SNP	G	G	A	rs147607028	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:92988086G>A	ENST00000268164.3	+	5	1006	c.769G>A	c.(769-771)Gag>Aag	p.E257K	ST8SIA2_ENST00000539113.1_Missense_Mutation_p.E236K	NM_006011.3	NP_006002.1	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	257					axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(2)|large_intestine(6)|lung(9)|skin(2)|urinary_tract(1)	20	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			GTGGGTCAACGAGCTTATCCT	0.642000													38	75					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50332845	50332845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50332845G>A	ENST00000394697.2	+	8	1319	c.979G>A	c.(979-981)Ggc>Agc	p.G327S	ADCY7_ENST00000566433.2_Missense_Mutation_p.G327S|ADCY7_ENST00000254235.3_Missense_Mutation_p.G327S|ADCY7_ENST00000564044.1_3'UTR|ADCY7_ENST00000537579.1_Missense_Mutation_p.G327S|ADCY7_ENST00000538642.1_Missense_Mutation_p.G327S			P51828	ADCY7_HUMAN	adenylate cyclase 7	327	Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CAAGATCCTCGGCGACTGCTA	0.627000													21	79					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103442096	103442096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103442096G>A	ENST00000361246.2	-	11	1720	c.1432C>T	c.(1432-1434)Ctc>Ttc	p.L478F		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	478					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GAATTGCTGAGGGCCCGAGAT	0.517000													14	222					0	0	1	0	0
CRTC2	200186	broad.mit.edu	37	1	153925837	153925837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153925837G>A	ENST00000368633.1	-	6	639	c.512C>T	c.(511-513)tCt>tTt	p.S171F	CRTC2_ENST00000476883.1_5'UTR|CRTC2_ENST00000368630.3_Intron	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	171					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCAGAGTCAGAGCTTGTCCT	0.587000													17	71					0	0	1	0	0
ACAD11	84129	broad.mit.edu	37	3	132298345	132298345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:132298345G>A	ENST00000264990.6	-	14	2650	c.1679C>T	c.(1678-1680)tCt>tTt	p.S560F	ACAD11_ENST00000545291.1_Missense_Mutation_p.S85F|ACAD11_ENST00000355458.3_Missense_Mutation_p.S560F	NM_032169.4	NP_115545.3			acyl-CoA dehydrogenase family, member 11											breast(2)|endometrium(6)|kidney(2)|large_intestine(8)|lung(10)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	36						CCTGGAGAGAGAAGTATTTTG	0.373000													17	79					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201287786	201287786	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201287786G>A	ENST00000263946.3	+	6	1346	c.1095G>A	c.(1093-1095)gaG>gaA	p.E365E	PKP1_ENST00000475988.1_3'UTR|PKP1_ENST00000367324.3_Silent_p.E365E|PKP1_ENST00000352845.3_Silent_p.E365E	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	365					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						AGCTGAAGGAGGAACTCATTG	0.597000													13	46					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1331458	1331458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1331458C>T	ENST00000381567.3	-	1	69	c.70G>A	c.(70-72)Gga>Aga	p.G24R	CRLF2_ENST00000381566.1_Missense_Mutation_p.G24R|CRLF2_ENST00000467626.1_5'UTR	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	24						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CCTGCTCCTCCTTGCCCCAAA	0.488000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								8	34					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	993927	993927	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:993927C>T	ENST00000537687.1	+	19	5380	c.4737C>T	c.(4735-4737)ccC>ccT	p.P1579P	WNK1_ENST00000535572.1_Silent_p.P1072P|WNK1_ENST00000315939.6_Silent_p.P1319P|WNK1_ENST00000530271.2_Silent_p.P1817P|WNK1_ENST00000340908.4_Silent_p.P912P	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1319					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CAGAAGGACCCAACACAGCAC	0.483000													43	99					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215263	140215263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140215263C>T	ENST00000525929.1	+	1	1295	c.1295C>T	c.(1294-1296)tCg>tTg	p.S432L	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.S432L|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGGGGGCTCGCCTTCTCTG	0.622000													54	142					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25439060	25439060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:25439060G>A	ENST00000278886.6	-	22	3875	c.3802C>T	c.(3802-3804)Ctt>Ttt	p.L1268F	NINL_ENST00000422516.1_Missense_Mutation_p.L919F|NINL_ENST00000464285.1_5'UTR	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	1268					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						TCTCCCTGAAGGCTGAGCAGG	0.687000													11	58					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294042	25294042	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25294042C>T	ENST00000400358.4	+	19	2183	c.2126C>T	c.(2125-2127)tCc>tTc	p.S709F	SGSM1_ENST00000400359.4_Missense_Mutation_p.S764F	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	764	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						GGCACTTGTTCCCCAGACTCG	0.562000													6	50					0	0	1	0	0
TANGO2	128989	broad.mit.edu	37	22	20043519	20043519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20043519C>T	ENST00000327374.4	+	6	612	c.434C>T	c.(433-435)cCt>cTt	p.P145L	TANGO2_ENST00000420290.2_Missense_Mutation_p.P47L|TANGO2_ENST00000447208.2_Missense_Mutation_p.P145L|TANGO2_ENST00000456048.1_Missense_Mutation_p.P150L|TANGO2_ENST00000401886.1_Intron|TANGO2_ENST00000398042.2_Intron|TANGO2_ENST00000434570.2_Missense_Mutation_p.P186L|TANGO2_ENST00000432883.1_Intron|TANGO2_ENST00000401833.1_Missense_Mutation_p.P186L	NM_152906.4	NP_690870.3			transport and golgi organization 2 homolog (Drosophila)																		GAGCCTGATCCTATCGTTTTG	0.567000													20	36					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60699279	60699279	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60699279G>A	ENST00000005286.4	+	6	1291	c.1138G>A	c.(1138-1140)Gaa>Aaa	p.E380K	TMEM132A_ENST00000453848.2_Missense_Mutation_p.E379K	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	379						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						CCAGGCCCCTGAAGCAGAGAA	0.592000													48	101					0	0	1	0	0
MFSD2A	84879	broad.mit.edu	37	1	40424494	40424494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40424494C>T	ENST00000372809.5	+	3	532	c.389C>T	c.(388-390)cCc>cTc	p.P130L	MFSD2A_ENST00000420632.2_Intron|MFSD2A_ENST00000372811.5_Missense_Mutation_p.P117L	NM_001136493.1	NP_001129965.1	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing 2A	130					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						CGCCTTATGCCCTGGTGAGTA	0.582000													81	177					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730674	57730674	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57730674G>A	ENST00000281282.5	+	2	555	c.477G>A	c.(475-477)aaG>aaA	p.K159K		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	159	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		ACCCTGAAAAGAATGAGTTGA	0.433000													16	87					0	0	1	0	0
DPEP3	64180	broad.mit.edu	37	16	68011711	68011711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68011711G>A	ENST00000268793.4	-	6	1226	c.853C>T	c.(853-855)Cgc>Tgc	p.R285C		NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	260					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		ATGCCCAGGCGGTTCAACTCC	0.498000													18	23					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8499829	8499829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8499829G>A	ENST00000381196.4	-	22	2683	c.2140C>T	c.(2140-2142)Cct>Tct	p.P714S	PTPRD_ENST00000358503.5_Missense_Mutation_p.P701S|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.P714S|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.P714S|PTPRD_ENST00000360074.4_Missense_Mutation_p.P701S|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000355233.5_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	714	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTGCGAGGAGGACCACTAGGA	0.443000										TSP Lung(15;0.13)			8	61					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766837	77766837	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77766837C>T	ENST00000521891.2	+	10	8128	c.7680C>T	c.(7678-7680)ccC>ccT	p.P2560P	ZFHX4_ENST00000050961.6_Silent_p.P2515P|ZFHX4_ENST00000455469.2_Silent_p.P2515P|ZFHX4_ENST00000518282.1_Silent_p.P2534P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2515						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTCAAATGCCCCCTCAGGCCA	0.498000										HNSCC(33;0.089)			17	63					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62026827	62026827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62026827G>A	ENST00000578147.1	-	15	2991	c.2915C>T	c.(2914-2916)cCc>cTc	p.P972L	SCN4A_ENST00000435607.1_Missense_Mutation_p.P972L			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	972					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CTCCTCGGGGGGCTTGTAGTC	0.642000													4	17					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139096	90139096	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90139096G>A	ENST00000492446.1	+	0	19																											GACCCAGTCAGGACACAGCAT	0.547000													46	191					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55739263	55739263	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55739263G>A	ENST00000370830.3	-	1	1099	c.401C>T	c.(400-402)cCt>cTt	p.P134L	BMP5_ENST00000446683.2_Missense_Mutation_p.P134L	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	134					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GGTGGTCAGAGGAGTCGTCCG	0.512000													24	92					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49049243	49049243	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49049243C>T	ENST00000395474.3	+	2	646	c.366C>T	c.(364-366)ctC>ctT	p.L122L	WDR6_ENST00000489684.1_Intron|WDR6_ENST00000448293.1_Silent_p.L41L|WDR6_ENST00000415265.2_Intron	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	92					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		GCAAGGGACTCCGAGTTGTGA	0.557000													60	155					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182007	57182007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:57182007G>A	ENST00000504228.1	+	6	2444	c.2339G>A	c.(2338-2340)cGg>cAg	p.R780Q	KIAA1211_ENST00000541073.1_Missense_Mutation_p.R773Q|KIAA1211_ENST00000264229.6_Missense_Mutation_p.R780Q			Q6ZU35	K1211_HUMAN	KIAA1211	780										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GAGATGCACCGGGAGCCCGCA	0.617000													23	73					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12666901	12666901	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12666901C>T	ENST00000425538.1	+	14	3101	c.2901C>T	c.(2899-2901)ttC>ttT	p.F967F	MYOCD_ENST00000343344.4_Silent_p.F919F|RP11-1090M7.1_ENST00000584772.1_RNA	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	919					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACATCGATTTCCTGGATGTCA	0.517000													17	26					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189931480	189931480	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189931480C>T	ENST00000374866.3	-	22	1704	c.1430G>A	c.(1429-1431)gGa>gAa	p.G477E		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	477					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCCAGCTTCTCCTTTGAAACC	0.378000													45	113					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711060	41711060	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41711060C>T	ENST00000400454.1	-	7	1970	c.1493G>A	c.(1492-1494)cGa>cAa	p.R498Q		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	498	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TACGTTTATTCGAGCCTGGTA	0.522000													17	60					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	921174	921174	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:921174G>A	ENST00000262301.11	-	7	1083	c.1065C>T	c.(1063-1065)ccC>ccT	p.P355P	LMF1_ENST00000543238.1_Silent_p.P118P|LMF1_ENST00000568897.1_Silent_p.P138P|LMF1_ENST00000568268.1_5'UTR|LMF1_ENST00000399843.2_Silent_p.P355P	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	355						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				ATCTGGGCTCGGGCCGGGCCC	0.667000													3	4					0	0	1	0	0
ZNF572	137209	broad.mit.edu	37	8	125989084	125989084	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:125989084G>A	ENST00000319286.5	+	3	728	c.574G>A	c.(574-576)Gaa>Aaa	p.E192K		NM_152412.2	NP_689625.2	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)	31	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CCAGTGTGGTGAATGTGGGAA	0.443000										HNSCC(60;0.17)			40	81					0	0	1	0	0
PPP1R36	145376	broad.mit.edu	37	14	65055925	65055925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65055925C>T	ENST00000298705.1	+	12	1234	c.1138C>T	c.(1138-1140)Ctt>Ttt	p.L380F	RP11-973N13.3_ENST00000554454.1_RNA|RP11-973N13.3_ENST00000556634.1_RNA	NM_172365.1	NP_758953.1	Q96LQ0	CN050_HUMAN	protein phosphatase 1, regulatory subunit 36	380																	GCTTCACCCCCTTGATCCAGA	0.428000													21	77					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176760486	176760486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176760486C>T	ENST00000367662.3	+	19	6052	c.4888C>T	c.(4888-4890)Ccc>Tcc	p.P1630S		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1630	Sushi 4.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						ATTCTAGCTTCCCATCCTCTG	0.408000													13	49					0	0	1	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733072	56733072	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56733072G>A	ENST00000587340.1	-	7	2058	c.1363C>T	c.(1363-1365)Ctg>Ttg	p.L455L	ZSCAN5A_ENST00000254165.3_Silent_p.L338L|ZSCAN5A_ENST00000592355.1_Silent_p.L454L|ZSCAN5A_ENST00000391713.1_Silent_p.L455L|ZSCAN5A_ENST00000587492.1_Silent_p.L309L			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	455					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TGCTCCTTCAGGCTCCCCCTG	0.507000													19	49					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62675553	62675553	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62675553G>A	ENST00000498273.1	+	4	1402	c.1107G>A	c.(1105-1107)gaG>gaA	p.E369E		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	369	Glu-rich.									breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						CTAAGCCAGAGGAGATGAAAA	0.438000													30	139					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138452929	138452929	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:138452929G>A	ENST00000344876.4	-	1	700	c.314C>T	c.(313-315)tCc>tTc	p.S105F	PCDH18_ENST00000412923.2_Missense_Mutation_p.S105F|PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	105	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					AAACTCTATGGAACAGTTCAA	0.413000													65	174					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640681	104640681	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104640681A>T	ENST00000304883.2	-	1	292	c.152T>A	c.(151-153)cTc>cAc	p.L51H		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	51						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGAGGAGGAGAGGTTGCCAGC	0.701000													25	43					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57330049	57330049	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57330049C>A	ENST00000326441.9	-	8	1054	c.691G>T	c.(691-693)Gtg>Ttg	p.V231L	PEG3_ENST00000423103.2_Missense_Mutation_p.V231L|ZIM2_ENST00000593711.1_Missense_Mutation_p.V106L|ZIM2_ENST00000601070.1_Missense_Mutation_p.V106L|PEG3_ENST00000593695.1_Missense_Mutation_p.V105L|PEG3_ENST00000598410.1_Missense_Mutation_p.V106L|ZIM2_ENST00000599935.1_Missense_Mutation_p.V106L|ZIM2_ENST00000391708.3_Missense_Mutation_p.V106L|ZIM2_ENST00000221722.5_Missense_Mutation_p.V106L	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	231					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGGTCCACCACATTTTGGTAT	0.483000													29	83					1.21669e-08	1.22096e-08	1	1	0
SLC31A1	1317	broad.mit.edu	37	9	116018469	116018469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116018469C>T	ENST00000374212.4	+	2	193	c.41C>T	c.(40-42)tCc>tTc	p.S14F	SLC31A1_ENST00000374210.6_Missense_Mutation_p.S14F|CDC26_ENST00000490408.1_Intron	NM_001859.3	NP_001850.1	O15431	COPT1_HUMAN	solute carrier family 31 (copper transporter), member 1	14						integral to plasma membrane	copper ion transmembrane transporter activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7						TATATGGACTCCAACAGTACC	0.438000													20	60					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70953128	70953128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70953128C>T	ENST00000334414.6	-	18	4753	c.4709G>A	c.(4708-4710)aGg>aAg	p.R1570K	PTPRB_ENST00000550857.1_Missense_Mutation_p.R1262K|PTPRB_ENST00000451516.2_Missense_Mutation_p.R1262K|PTPRB_ENST00000551525.1_Missense_Mutation_p.R1569K|PTPRB_ENST00000550358.1_Missense_Mutation_p.R1482K|PTPRB_ENST00000538708.1_Missense_Mutation_p.R1262K|PTPRB_ENST00000261266.5_Missense_Mutation_p.R1352K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1352					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CATACTTGTCCTCACAGATCC	0.383000													62	127					0	0	1	0	0
F2RL3	9002	broad.mit.edu	37	19	17001309	17001309	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17001309C>T	ENST00000248076.3	+	2	1365	c.1035C>T	c.(1033-1035)gcC>gcT	p.A345A		NM_003950.2	NP_003941.2	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	345					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						ACGTGTCGGCCGAGTTCAGGG	0.672000													6	31					0	0	1	0	0
CYP2B6	1555	broad.mit.edu	37	19	41510233	41510233	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41510233G>A	ENST00000324071.4	+	3	373	c.366G>A	c.(364-366)aaG>aaA	p.K122K	CYP2B6_ENST00000330446.5_Silent_p.K82K|CYP2B6_ENST00000593831.1_Silent_p.K46K|CYP2B6_ENST00000598834.1_3'UTR	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	122					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ACCGCTGGAAGGTGCTTCGGC	0.552000													10	37					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4231288	4231288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4231288C>T	ENST00000221847.5	+	2	221	c.168C>T	c.(166-168)tcC>tcT	p.S56S		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	56	Fibronectin type-III 1.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCAAACTCCACCAGCCCCG	0.657000													4	27					0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17507491	17507491	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17507491A>T	ENST00000229922.2	+	5	924	c.392A>T	c.(391-393)aAt>aTt	p.N131I	CAP2_ENST00000489374.1_Intron|CAP2_ENST00000493172.1_Intron|CAP2_ENST00000465994.1_Missense_Mutation_p.N131I|CAP2_ENST00000378990.2_Missense_Mutation_p.N105I	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	131					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			AACATGTTTAATCATCTTTCG	0.488000													35	68					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47500803	47500803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47500803G>A	ENST00000285039.7	-	10	1538	c.1239C>T	c.(1237-1239)ttC>ttT	p.F413F		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	413	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CAATCCAGCCGAACAACTGGG	0.592000													39	66					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	158074052	158074052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:158074052G>A	ENST00000264428.4	+	9	1357	c.1087G>A	c.(1087-1089)Gaa>Aaa	p.E363K	GLRB_ENST00000541722.1_Intron|GLRB_ENST00000509282.1_Missense_Mutation_p.E363K|GLRB_ENST00000512619.1_Intron	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	363					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GGTTGAAGCTGAAAAAGCCAG	0.448000													15	51					0	0	1	0	0
ELOVL2	54898	broad.mit.edu	37	6	10995328	10995328	+	Silent	SNP	C	C	T	rs141887901		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:10995328C>T	ENST00000354666.3	-	5	500	c.417G>A	c.(415-417)acG>acA	p.T139T		NM_017770.3	NP_060240.3	Q9NXB9	ELOV2_HUMAN	ELOVL fatty acid elongase 2	139					fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|stomach(1)|upper_aerodigestive_tract(2)	14	Breast(50;0.0418)|Ovarian(93;0.0919)	all_hematologic(90;0.117)	Epithelial(50;0.176)			TAATCTGACTCGTTTTTTTCC	0.358000													49	110					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20548670	20548670	+	Silent	SNP	C	C	T	rs71811918		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20548670C>T	ENST00000329697.6	-	14	1812	c.1644G>A	c.(1642-1644)ttG>ttA	p.L548L	ACSM2B_ENST00000565232.1_Silent_p.L548L|ACSM2B_ENST00000565322.1_Silent_p.L469L|ACSM2B_ENST00000567001.1_Silent_p.L548L	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	548					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TGGGCAGGTTCAAGACAAACT	0.493000													85	162					0	0	1	0	0
ARL5B	221079	broad.mit.edu	37	10	18964126	18964126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:18964126C>T	ENST00000377275.3	+	6	754	c.521C>T	c.(520-522)tCc>tTc	p.S174F		NM_178815.3	NP_848930.1	Q96KC2	ARL5B_HUMAN	ADP-ribosylation factor-like 5B	174					small GTPase mediated signal transduction	intracellular	GTP binding			lung(1)|ovary(1)	2						TGGATGACCTCCCGGATTGGT	0.343000													11	84					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	66048628	66048628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:66048628G>A	ENST00000443035.3	-	3	376	c.161C>T	c.(160-162)tCt>tTt	p.S54F	DENND4A_ENST00000431932.2_Missense_Mutation_p.S54F	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	54	MABP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						CTCCCCAAGAGATTTGATAAT	0.378000													7	35					0	0	1	0	0
HMGN4	10473	broad.mit.edu	37	6	26545639	26545639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:26545639C>T	ENST00000377575.2	+	2	382	c.205C>T	c.(205-207)Cct>Tct	p.P69S		NM_006353.2	NP_006344.1	O00479	HMGN4_HUMAN	high mobility group nucleosomal binding domain 4	69						chromatin|nucleus	DNA binding			lung(2)|skin(1)	3						TGGGAACAACCCTGCAAAAAA	0.493000													33	93					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169548310	169548310	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:169548310C>T	ENST00000340806.6	+	3	1225	c.1225C>T	c.(1225-1227)Cat>Tat	p.H409Y		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	409										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						AGAGAACAATCATCTGGAGTA	0.383000													4	15					0	0	1	0	0
MAP4K5	11183	broad.mit.edu	37	14	50912805	50912805	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:50912805G>A	ENST00000013125.4	-	17	1495	c.1177C>T	c.(1177-1179)Cct>Tct	p.P393S		NM_006575.4|NM_198794.2	NP_006566.2|NP_942089.1	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase kinase 5	393					activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_epithelial(31;0.000415)|Breast(41;0.0102)					ACCTTAGGAGGTAGGGGAGGT	0.284000													5	35					0	0	1	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	159584018	159584018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159584018C>T	ENST00000337808.6	+	3	1403	c.826C>T	c.(826-828)Cca>Tca	p.P276S	SCHIP1_ENST00000445224.2_Missense_Mutation_p.P33S|SCHIP1_ENST00000482804.1_Missense_Mutation_p.P49S|IQCJ-SCHIP1_ENST00000485419.1_Missense_Mutation_p.P352S|IQCJ-SCHIP1_ENST00000412423.2_Missense_Mutation_p.P263S|IQCJ-SCHIP1_ENST00000527095.1_Missense_Mutation_p.P44S|IQCJ-SCHIP1_ENST00000476809.1_Missense_Mutation_p.P325S|IQCJ-SCHIP1_ENST00000460298.1_Missense_Mutation_p.P236S	NM_001197107.1|NM_014575.3	NP_001184036.1|NP_055390.1	Q9P0W5	SCHI1_HUMAN		276						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						TGATGATGGCCCAGGAATTTA	0.398000													59	165					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121880150	121880150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121880150G>A	ENST00000377069.4	-	18	3293	c.2887C>T	c.(2887-2889)Ccg>Tcg	p.P963S	KDM2B_ENST00000377071.4_Missense_Mutation_p.P1032S|KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000542973.1_Missense_Mutation_p.P400S	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	1032					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CACTTGGGCGGGGACACGGAG	0.721000													3	11					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50957857	50957857	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50957857C>T	ENST00000374103.4	-	8	987	c.902G>A	c.(901-903)aGg>aAg	p.R301K	OGDHL_ENST00000419399.1_Missense_Mutation_p.R244K|OGDHL_ENST00000432695.1_Missense_Mutation_p.R92K	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	301					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CACGTTCAGCCTTCCCCTGGA	0.667000													7	12					0	0	1	0	0
DPRX	503834	broad.mit.edu	37	19	54140039	54140039	+	Nonsense_Mutation	SNP	C	C	T	rs150237904		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54140039C>T	ENST00000376650.1	+	3	424	c.373C>T	c.(373-375)Cga>Tga	p.R125*		NM_001012728.1	NP_001012746.1	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	125						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|large_intestine(1)|lung(7)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		CACGGGTCATCGAGTCCCCTC	0.567000													12	99					0	0	1	0	0
LONRF3	79836	broad.mit.edu	37	X	118145875	118145875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:118145875C>T	ENST00000365713.2	+	7	1790	c.1627C>T	c.(1627-1629)Cgt>Tgt	p.R543C	LONRF3_ENST00000371628.3_Missense_Mutation_p.R584C|LONRF3_ENST00000304778.7_Missense_Mutation_p.R543C|LONRF3_ENST00000422289.2_Missense_Mutation_p.R328C|LONRF3_ENST00000472173.1_3'UTR			Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger 3	584					proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	36						CCTGATGATTCGTAGATGCAT	0.493000													51	37					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796874	62796874	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62796874G>A	ENST00000582986.1	-	0	1046					NR_024386.1																						GACTCACAGCGAAGCAGGGAG	0.627000													10	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179596949	179596949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179596949C>T	ENST00000589042.1	-	57	16971	c.16747G>A	c.(16747-16749)Gaa>Aaa	p.E5583K	TTN_ENST00000342992.6_Missense_Mutation_p.E4339K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E5266K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5266	Ig-like 36.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTAATTTCTCTATCATTT	0.428000													48	154					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132193081	132193081	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:132193081C>T	ENST00000359827.3	-	2	1334	c.372G>A	c.(370-372)gaG>gaA	p.E124E	PLXNA4_ENST00000423507.2_Silent_p.E124E|PLXNA4_ENST00000378539.5_Silent_p.E124E|PLXNA4_ENST00000321063.4_Silent_p.E124E			Q9HCM2	PLXA4_HUMAN	plexin A4	124	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCAGCCTGTTCTCCTTGTAGT	0.547000													16	54					0	0	1	0	0
HERC6	55008	broad.mit.edu	37	4	89304376	89304376	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89304376C>T	ENST00000380265.5	+	2	386	c.203C>T	c.(202-204)cCa>cTa	p.P68L	HERC6_ENST00000273960.3_Missense_Mutation_p.P68L|HERC6_ENST00000264346.7_Missense_Mutation_p.P68L	NM_001165136.1	NP_001158608.1	Q8IVU3	HERC6_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	68					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		CCCAAAGAACCAATTCAGGCA	0.453000													3	13					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191233	152191233	+	Missense_Mutation	SNP	C	C	T	rs138860104	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152191233C>T	ENST00000368801.2	-	3	2947	c.2872G>A	c.(2872-2874)Gaa>Aaa	p.E958K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	958					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGTGTTGTTCGTAGCTGGAG	0.552000													135	331					0	0	1	0	0
KYNU	8942	broad.mit.edu	37	2	143712381	143712381	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:143712381G>A	ENST00000264170.4	+	5	634	c.376G>A	c.(376-378)Gcc>Acc	p.A126T	KYNU_ENST00000409512.1_Missense_Mutation_p.A126T|KYNU_ENST00000375773.2_Missense_Mutation_p.A126T	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	126					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity	p.A126T(1)		large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTTTACAGGAGCCAATGAGAA	0.299000													27	68					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973592	29973592	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:29973592G>A	ENST00000378993.1	+	11	2419	c.1746G>A	c.(1744-1746)ggG>ggA	p.G582G	IL1RAPL1_ENST00000302196.4_Silent_p.G582G	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	582	Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						GGCCTTTTGGGGAGCTGCAGA	0.512000													12	13					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38485983	38485983	+	Missense_Mutation	SNP	C	C	T	rs143995164		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38485983C>T	ENST00000263409.4	-	17	2597	c.2435G>A	c.(2434-2436)cGa>cAa	p.R812Q	LIFR_ENST00000453190.2_Missense_Mutation_p.R812Q	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	812	Fibronectin type-III 6.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity	p.R812Q(2)		NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TGTATAGGCTCGCAAGACCAG	0.433000			T	PLAG1	salivary adenoma								21	63					0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48602074	48602074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48602074C>T	ENST00000340553.3	+	7	1049	c.788C>T	c.(787-789)cCt>cTt	p.P263L		NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2	263					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			AAGCCTCTTCCTCTTAAAACA	0.378000													13	63					0	0	1	0	0
KCNJ6	3763	broad.mit.edu	37	21	38997691	38997691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:38997691C>T	ENST00000400482.3	-	4	1631	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	KCNJ6_ENST00000288309.6_Missense_Mutation_p.E348K	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	348					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	TAGTCAACTTCGTAGAACCCG	0.567000													20	77					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15655019	15655019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15655019G>A	ENST00000269703.2	+	10	1264	c.1065G>A	c.(1063-1065)ccG>ccA	p.P355P	CYP4F22_ENST00000601005.2_Silent_p.P355P	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	355						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						CAAAGTATCCGGAATACCAGG	0.537000													39	75					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72349019	72349019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72349019G>A	ENST00000389916.4	+	15	2178	c.2040G>A	c.(2038-2040)ctG>ctA	p.L680L		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	680					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						ATTCTGACCTGGAGAGTGTGA	0.597000													32	82					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59189495	59189495	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59189495C>T	ENST00000302040.4	-	1	954	c.932G>A	c.(931-933)gGg>gAg	p.G311E		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						GTGAGAAATCCCGGGGTCCCT	0.413000													48	113					0	0	1	0	0
NDUFB7	4713	broad.mit.edu	37	19	14682756	14682756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14682756G>A	ENST00000215565.2	-	1	118	c.57C>T	c.(55-57)ccC>ccT	p.P19P		NM_004146.5	NP_004137.2	P17568	NDUB7_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa	19					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8					NADH(DB00157)	GCATCTGCAGGGGGTCGGGCT	0.716000													4	15					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587807	247587807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247587807C>T	ENST00000366497.2	+	4	1842	c.1062C>T	c.(1060-1062)gcC>gcT	p.A354A	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Silent_p.A354A|NLRP3_ENST00000336119.3_Silent_p.A354A|NLRP3_ENST00000348069.2_Silent_p.A354A|NLRP3_ENST00000391828.3_Silent_p.A354A|NLRP3_ENST00000391827.2_Silent_p.A354A	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	354	NACHT.		A -> V (in MWS).		detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GACCTGTGGCCCTGGAGAAAC	0.557000													7	93					0	0	1	0	0
ADGRE4P	326342	broad.mit.edu	37	19	6981116	6981116	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6981116C>T	ENST00000600751.1	-	0	563					NR_024075.1																						AAATTTGACCCTTTCCTGGAG	0.443000													9	15					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45384947	45384947	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45384947G>A	ENST00000559488.1	+	14	2261	c.2245G>A	c.(2245-2247)Gac>Aac	p.D749N	ITGB3_ENST00000435993.2_Missense_Mutation_p.D702N|ITGB3_ENST00000560629.1_Missense_Mutation_p.R737Q|RP11-290H9.4_ENST00000575039.1_RNA	NM_000212.2	NP_000203.2	P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	749					activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	CACCATCCACGACCGAAAAGA	0.537000													18	27					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11572916	11572916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11572916C>T	ENST00000262442.3	+	17	3226	c.3158C>T	c.(3157-3159)cCc>cTc	p.P1053L	DNAH9_ENST00000454412.2_Missense_Mutation_p.P1053L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1053	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAGAACCCTCCCCTCCTTTCT	0.507000													37	77					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43808945	43808945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43808945G>A	ENST00000403856.1	-	9	803	c.656C>T	c.(655-657)tCc>tTc	p.S219F	THADA_ENST00000405006.4_Missense_Mutation_p.S219F|THADA_ENST00000402360.2_Missense_Mutation_p.S219F|THADA_ENST00000405975.2_Missense_Mutation_p.S219F|THADA_ENST00000404790.1_Missense_Mutation_p.S219F|THADA_ENST00000415080.2_5'UTR			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	219							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GGGAGAATCGGAAGTCTTCCA	0.333000													18	73					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26877949	26877949	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26877949C>T	ENST00000374168.2	+	5	523	c.369C>T	c.(367-369)ttC>ttT	p.F123F	RPS6KA1_ENST00000526792.1_Silent_p.F31F|RPS6KA1_ENST00000374166.4_Silent_p.F123F|RPS6KA1_ENST00000374162.2_Silent_p.F31F|RPS6KA1_ENST00000531382.1_Silent_p.F132F|RPS6KA1_ENST00000530003.1_Silent_p.F107F	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	123	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		ATCACCCATTCGTGGTGAAGC	0.567000													12	31					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17548851	17548851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17548851C>T	ENST00000005226.7	-	5	414	c.415G>A	c.(415-417)Gga>Aga	p.G139R	USH1C_ENST00000527720.1_Missense_Mutation_p.G108R|USH1C_ENST00000527020.1_Missense_Mutation_p.G139R|USH1C_ENST00000318024.4_Missense_Mutation_p.G139R	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	139	PDZ 1.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						ATGGAATATCCATTGATCCGG	0.547000													22	67					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175682	143175682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143175682C>T	ENST00000408916.1	+	1	717	c.717C>T	c.(715-717)ttC>ttT	p.F239F	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	239					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TCATCTCCTTCCTCATTCTTT	0.512000													43	84					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69972933	69972933	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69972933G>A	ENST00000305231.7	+	4	1089	c.1043G>A	c.(1042-1044)gGt>gAt	p.G348D	UGT2B7_ENST00000508661.1_Missense_Mutation_p.G348D|UGT2B7_ENST00000509763.1_3'UTR	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	348					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GATACCTTAGGTCTCAATACT	0.358000													30	117					0	0	1	0	0
GJA1	2697	broad.mit.edu	37	6	121768083	121768083	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:121768083C>T	ENST00000282561.3	+	2	247	c.90C>T	c.(88-90)ttC>ttT	p.F30F		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	30					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CAGTACTTTTCATTTTCCGAA	0.532000													32	61					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170715801	170715801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170715801C>T	ENST00000314251.3	-	11	1545	c.1466G>A	c.(1465-1467)gGa>gAa	p.G489E	SLC2A2_ENST00000382808.4_Missense_Mutation_p.G370E	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	489					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			AAAAGACTTTCCTTTGGTTTC	0.438000													8	133					0	0	1	0	0
OR1J2	26740	broad.mit.edu	37	9	125273455	125273455	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125273455C>T	ENST00000335302.5	+	1	375	c.375C>T	c.(373-375)gcC>gcT	p.A125A		NM_054107.1	NP_473448.1	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J, member 2	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						GATATGTTGCCATATGTCACC	0.423000													19	84					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166900519	166900519	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166900519C>T	ENST00000423058.2	-	11	1720	c.1703G>A	c.(1702-1704)cGa>cAa	p.R568Q	AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.R568Q|SCN1A_ENST00000303395.4_Missense_Mutation_p.R568Q|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.R568Q	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	568						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTGCTATTTCGCCTTGGTGA	0.418000													30	63					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158577148	158577148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158577148G>A	ENST00000361284.1	+	1	920	c.920G>A	c.(919-921)gGg>gAg	p.G307E		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					GCTTTCAGAGGGAGATTGCTG	0.468000													60	157					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	708645	708645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:708645G>A	ENST00000549091.1	+	23	2979	c.2887G>A	c.(2887-2889)Ggc>Agc	p.G963S	WDR90_ENST00000293879.4_Missense_Mutation_p.G963S	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	963										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GGCCAGCCCAGGCCCCCAGGT	0.697000													9	24					0	0	1	0	0
CHGA	1113	broad.mit.edu	37	14	93398965	93398965	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93398965G>A	ENST00000216492.5	+	7	1339	c.1059G>A	c.(1057-1059)acG>acA	p.T353T	CHGA_ENST00000334654.4_Silent_p.T202T	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	353					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		AGGAGCTGACGGCTGAGAAGC	0.657000													4	8					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8656896	8656896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8656896C>T	ENST00000270328.4	-	13	1945	c.1679G>A	c.(1678-1680)aGc>aAc	p.S560N	ADAMTS10_ENST00000595838.1_Missense_Mutation_p.A51T|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.S560N			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	560	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						ACAGGTCCGGCTGCAGTCGCC	0.711000													11	33					0	0	1	0	0
PCMTD2	55251	broad.mit.edu	37	20	62904588	62904588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62904588C>T	ENST00000308824.6	+	6	848	c.721C>T	c.(721-723)Cgc>Tgc	p.R241C	PCMTD2_ENST00000299468.7_Intron|PCMTD2_ENST00000369758.3_Missense_Mutation_p.R214C|PCMTD2_ENST00000266078.6_Missense_Mutation_p.R17C	NM_018257.2	NP_060727.2	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	241						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(9)|upper_aerodigestive_tract(1)	17	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGTGGCAGTTCGCAGCCTCCA	0.507000													18	69					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876420	35876420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35876420C>T	ENST00000303115.3	+	8	1341	c.1212C>T	c.(1210-1212)ctC>ctT	p.L404L	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	404					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ACCAGGACCTCCTGCTTAGCC	0.547000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						21	34					0	0	1	0	0
ARSI	340075	broad.mit.edu	37	5	149678054	149678054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149678054C>T	ENST00000328668.7	-	2	1012	c.433G>A	c.(433-435)Gtg>Atg	p.V145M		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	145						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CACTTGCCCACCATATGGGTG	0.612000													16	37					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118867030	118867030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:118867030G>A	ENST00000295622.1	+	2	1442	c.1402G>A	c.(1402-1404)Gaa>Aaa	p.E468K	RP11-484M3.5_ENST00000490594.1_Intron	NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	468										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		ATTTCAGGATGAATTTTCAGA	0.363000													45	123					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141012408	141012408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:141012408G>A	ENST00000277549.5	+	43	5939	c.3370G>A	c.(3370-3372)Gag>Aag	p.E1124K	CACNA1B_ENST00000277551.2_Missense_Mutation_p.E1930K|CACNA1B_ENST00000371372.1_Missense_Mutation_p.E1930K|CACNA1B_ENST00000371363.1_Missense_Mutation_p.E1928K|CACNA1B_ENST00000371355.4_Missense_Mutation_p.E1931K|CACNA1B_ENST00000371357.1_Missense_Mutation_p.E1929K			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1930					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	ACAAAACCAAGAGAGTGGCAT	0.567000													4	22					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152553713	152553713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152553713C>T	ENST00000427231.2	-	16	1621	c.1419G>A	c.(1417-1419)caG>caA	p.Q473Q	NEB_ENST00000409198.1_Silent_p.Q473Q|NEB_ENST00000397345.3_Silent_p.Q473Q|NEB_ENST00000604864.1_Silent_p.Q473Q|NEB_ENST00000172853.10_Silent_p.Q473Q|NEB_ENST00000603639.1_Silent_p.Q473Q	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	473					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GAGTTATGGTCTGAGGGAAGA	0.383000													13	61					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123428651	123428651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123428651G>A	ENST00000360772.3	-	15	2272	c.1894C>T	c.(1894-1896)Ctc>Ttc	p.L632F	MYLK_ENST00000346322.5_Missense_Mutation_p.L563F|MYLK_ENST00000359169.1_Missense_Mutation_p.L632F|MYLK_ENST00000475616.1_Missense_Mutation_p.L632F|MYLK_ENST00000360304.3_Missense_Mutation_p.L632F			Q15746	MYLK_HUMAN	myosin light chain kinase	632	Ig-like C2-type 5.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ATGACTTTGAGATCAGAGAGG	0.512000													78	360					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47210392	47210392	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47210392G>A	ENST00000300404.2	+	1	64	c.5G>A	c.(4-6)gGg>gAg	p.G2E	B4GALNT2_ENST00000504681.1_Intron|B4GALNT2_ENST00000393354.2_Intron	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	2					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			CCAGGAATGGGGAGCGCTGGC	0.647000													8	17					0	0	1	0	0
EDEM1	9695	broad.mit.edu	37	3	5229451	5229451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:5229451C>T	ENST00000600805.1	-	1	531	c.532G>A	c.(532-534)Ggc>Agc	p.G178S	EDEM1_ENST00000256497.4_5'UTR																							GCGGGGAGGCCCCCGCGCTTT	0.687000													4	6					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604061	179604061	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179604061T>A	ENST00000589042.1	-	48	14123	c.13899A>T	c.(13897-13899)aaA>aaT	p.K4633N	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.K4270N|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.K4462N|TTN_ENST00000359218.5_Missense_Mutation_p.K4395N|TTN_ENST00000591111.1_Missense_Mutation_p.K4316N|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4316	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTCACCTCTTTAGCATTTG	0.368000													14	35					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072298	134072298	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:134072298C>T	ENST00000264360.4	+	1	1829	c.1003C>T	c.(1003-1005)Ccc>Tcc	p.P335S		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	335	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		GGACCTGGGCCCCAACGCCGT	0.602000													20	123					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160783618	160783618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160783618C>T	ENST00000263285.5	+	3	677	c.647C>T	c.(646-648)cCa>cTa	p.P216L	LY9_ENST00000471816.1_3'UTR|LY9_ENST00000341032.4_Missense_Mutation_p.P216L|LY9_ENST00000368040.1_5'UTR|LY9_ENST00000368041.2_Missense_Mutation_p.P176L	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	216	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCATGTGACCCAGACCTGCCA	0.552000													65	230					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10468410	10468410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10468410G>A	ENST00000529370.1	-	17	2826	c.2496C>T	c.(2494-2496)ccC>ccT	p.P832P	TYK2_ENST00000264818.6_Intron|TYK2_ENST00000525621.1_Intron|TYK2_ENST00000524462.1_Intron			P29597	TYK2_HUMAN	tyrosine kinase 2	0	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCCCCACTGCGGGGAGGGCCC	0.612000													5	5					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229706	21229706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21229706G>A	ENST00000233242.1	-	26	10161	c.10034C>T	c.(10033-10035)tCa>tTa	p.S3345L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3345					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATGACACTTGATTTAAAGGA	0.368000													42	136					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36641014	36641014	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36641014G>A	ENST00000373448.2	-	3	1443	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	TTI1_ENST00000373447.3_Missense_Mutation_p.S402F|TTI1_ENST00000449821.1_Missense_Mutation_p.S402F|TTI1_ENST00000487362.1_Intron	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	402							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AAGTAACAAGGAAAGAGTAGA	0.478000													45	84					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6587206	6587206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:6587206G>A	ENST00000321612.6	-	15	1935	c.1785C>T	c.(1783-1785)ttC>ttT	p.F595F		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	595					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAAGCTCTCGGAAAAGCTGCT	0.413000													35	62					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240341321	240341321	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240341321C>T	ENST00000319653.9	+	3	2113	c.1883C>T	c.(1882-1884)cCa>cTa	p.P628L	RP11-567G24.3_ENST00000412311.1_RNA|RP11-567G24.3_ENST00000444308.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	628					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ATGGGGCCACCATCCAAACCT	0.493000													17	60					0	0	1	0	0
ZNF385B	151126	broad.mit.edu	37	2	180634324	180634324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:180634324G>A	ENST00000410066.1	-	3	762	c.159C>T	c.(157-159)tcC>tcT	p.S53S		NM_152520.4	NP_689733.3	Q569K4	Z385B_HUMAN	zinc finger protein 385B	53						nucleus	nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	26			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			ATTTGCCGTTGGAATGCACCT	0.562000													19	65					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93528871	93528871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93528871C>T	ENST00000394196.4	+	26	4449	c.3381C>T	c.(3379-3381)ctC>ctT	p.L1127L	CHD2_ENST00000557381.1_Silent_p.L1127L	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1127					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GGAAGGACCTCGTGGAGGGAT	0.527000													82	137					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161173184	161173184	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161173184C>T	ENST00000308192.9	+	18	2226	c.2163C>T	c.(2161-2163)ctC>ctT	p.L721L		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	721	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AAGCCCAGCTCCCTGTGATTG	0.468000													17	39					0	0	1	0	0
TEX29	121793	broad.mit.edu	37	13	111992259	111992259	+	Silent	SNP	C	C	T	rs34403563	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111992259C>T	ENST00000283547.1	+	4	348	c.219C>T	c.(217-219)ttC>ttT	p.F73F		NM_152324.1	NP_689537.1	Q8N6K0	CM016_HUMAN	testis expressed 29	73						integral to membrane											CTGGGGCCTTCGTCATCACCA	0.522000													47	124					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76433779	76433779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76433779C>T	ENST00000389840.5	-	74	12083	c.11959G>A	c.(11959-11961)Gag>Aag	p.E3987K	DNAH17_ENST00000585328.1_Missense_Mutation_p.E3988K|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17									p.E3988Q(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GTGGGGGGCTCGTTGGTGATC	0.657000													17	29					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63047835	63047835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:63047835C>T	ENST00000561311.1	+	36	4811	c.4581C>T	c.(4579-4581)ttC>ttT	p.F1527F	TLN2_ENST00000306829.6_Silent_p.F1527F			Q9Y4G6	TLN2_HUMAN	talin 2	1527					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AGAGGCACTTCGTCCAGTCAG	0.562000													14	68					0	0	1	0	0
CGA	1081	broad.mit.edu	37	6	87796037	87796037	+	Silent	SNP	C	C	T	rs142907318		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:87796037C>T	ENST00000369582.2	-	3	304	c.204G>A	c.(202-204)aaG>aaA	p.K68K		NM_000735.3	NP_000726.1	P01215	GLHA_HUMAN	glycoprotein hormones, alpha polypeptide	68					hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity			NS(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)	15		all_cancers(76;5.98e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000102)		BRCA - Breast invasive adenocarcinoma(108;0.0484)		ACATCGTCTTCTTGGACCTTA	0.493000													51	126					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30724930	30724930	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30724930C>T	ENST00000262518.4	+	16	2776	c.2391C>T	c.(2389-2391)ttC>ttT	p.F797F	SRCAP_ENST00000395059.2_Silent_p.F797F|SRCAP_ENST00000344771.4_Silent_p.F797F	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	797					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CCCATGTCTTCCAGTCTCATC	0.517000													41	148					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51975321	51975321	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51975321G>A	ENST00000220478.3	+	3	584	c.181_splice	c.e3+1	p.E61_splice	SCG3_ENST00000542355.2_5'UTR	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	61					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		ATATCCTCCAGGTAAAAAGAA	0.348000													56	118					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376321	113376321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113376321G>A	ENST00000316407.4	-	7	4618	c.4208C>T	c.(4207-4209)cCa>cTa	p.P1403L	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.P1403L	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1403					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GTTACTAGGTGGAAATAATCG	0.463000													16	58					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228525721	228525721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228525721G>A	ENST00000570156.2	+	78	19822	c.19748G>A	c.(19747-19749)gGc>gAc	p.G6583D	OBSCN_ENST00000366707.4_Missense_Mutation_p.G3260D|OBSCN_ENST00000422127.1_Missense_Mutation_p.G5626D|OBSCN_ENST00000284548.11_Missense_Mutation_p.G5626D|OBSCN_ENST00000366709.4_Missense_Mutation_p.G2745D	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5626	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CTGCGGGAAGGCCAGTATGTG	0.632000													9	12					0	0	1	0	0
BEX1	55859	broad.mit.edu	37	X	102318005	102318005	+	Missense_Mutation	SNP	C	C	T	rs1045082		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:102318005C>T	ENST00000372728.3	-	3	437	c.198G>A	c.(196-198)atG>atA	p.M66I		NM_018476.3	NP_060946.3	Q9HBH7	BEX1_HUMAN	brain expressed, X-linked 1	66			M -> I (in dbSNP:rs1045082).		cell differentiation|nervous system development	cytoplasm|nucleus				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12						GCCTATGCATCATATCCCATC	0.517000													117	62					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123498383	123498383	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123498383G>A	ENST00000280562.5	-	3	490	c.285C>T	c.(283-285)acC>acT	p.T95T	PITPNM2_ENST00000320201.4_Silent_p.T95T|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000546049.1_Silent_p.T95T|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Silent_p.T95T			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	95					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		ACCTGGTTCGGGTGTAGGGGT	0.602000													5	23					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21016731	21016731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21016731G>A	ENST00000247986.2	-	7	1641	c.1331C>T	c.(1330-1332)tCa>tTa	p.S444L	KIF17_ENST00000490034.1_5'UTR|KIF17_ENST00000400463.3_Missense_Mutation_p.S444L|KIF17_ENST00000375044.1_Missense_Mutation_p.S344L			Q9P2E2	KIF17_HUMAN	kinesin family member 17	444					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GACGTCATATGAGTTGCGCAT	0.627000													22	56					0	0	1	0	0
SEC14L3	266629	broad.mit.edu	37	22	30867933	30867933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30867933C>T	ENST00000215812.4	-	1	103	c.13G>A	c.(13-15)Gtt>Att	p.V5I	SEC14L3_ENST00000403066.1_5'UTR|SEC14L3_ENST00000402286.1_5'UTR|SEC14L3_ENST00000539629.1_5'UTR|SEC14L3_ENST00000401751.1_5'UTR	NM_174975.4	NP_777635.1	Q9UDX4	S14L3_HUMAN	SEC14-like 3 (S. cerevisiae)	5						integral to membrane|intracellular	lipid binding|transporter activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	19					Vitamin E(DB00163)	AGGTCTCCAACTCGGCCGCTC	0.632000													39	82					0	0	1	0	0
MCHR2	84539	broad.mit.edu	37	6	100390947	100390947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:100390947C>T	ENST00000281806.2	-	4	779	c.465G>A	c.(463-465)ttG>ttA	p.L155L	MCHR2_ENST00000369212.1_Silent_p.L155L|MCHR2_ENST00000445970.1_Silent_p.L155L	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	155						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CCCAAAGGCCCAAATTGATCC	0.473000													38	86					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56477606	56477606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56477606G>A	ENST00000291971.3	+	5	2312	c.2241G>A	c.(2239-2241)ttG>ttA	p.L747L	NLRP8_ENST00000590542.1_Silent_p.L747L	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	747						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GCACCATGTTGAACCAGGACT	0.493000													55	123					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416472	29416472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29416472C>T	ENST00000389048.3	-	29	5387	c.4481G>A	c.(4480-4482)gGa>gAa	p.G1494E	ALK_ENST00000431873.1_Missense_Mutation_p.G324E	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1494					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GTTTCTGGATCCGTGGACCTT	0.527000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				32	129					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228402555	228402555	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228402555C>T	ENST00000570156.2	+	5	1658	c.1584C>T	c.(1582-1584)tcC>tcT	p.S528S	OBSCN_ENST00000422127.1_Silent_p.S528S|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.S528S	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	528	Fibronectin type-III 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGGAGAGTTCCGTGATTCTCA	0.592000													10	19					0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57268309	57268309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57268309G>A	ENST00000278426.3	-	5	763	c.408C>T	c.(406-408)ttC>ttT	p.F136F	SLC43A1_ENST00000528450.1_Silent_p.F136F	NM_003627.5	NP_003618.1	O75387	LAT3_HUMAN	solute carrier family 43 (amino acid system L transporter), member 1	136					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						ACAGCGCCAGGAATATCAACG	0.587000													12	27					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58567466	58567466	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58567466C>T	ENST00000348616.4	+	10	1617	c.1317C>T	c.(1315-1317)gtC>gtT	p.V439V	CDH26_ENST00000244047.5_Silent_p.V439V	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	439	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CAAATTGGGTCAGCGTCGACA	0.383000													11	40					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408206	29408206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29408206G>A	ENST00000444197.2	+	1	1124	c.414G>A	c.(412-414)cgG>cgA	p.R138R	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	138			R -> W (in dbSNP:rs17177646).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TGAGCCACCGGGTGTGTCTAC	0.637000													8	65					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79454396	79454396	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:79454396T>G	ENST00000554719.1	+	12	2546	c.2055T>G	c.(2053-2055)tgT>tgG	p.C685W	NRXN3_ENST00000335750.5_Missense_Mutation_p.C685W	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		AAGATTCATGTGCCAACCAGG	0.433000													28	62					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170030438	170030438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170030438C>T	ENST00000263816.3	-	56	11290	c.11005G>A	c.(11005-11007)Gaa>Aaa	p.E3669K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3669	LDL-receptor class A 29.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGCATTCTTCAATGGGCTCA	0.557000													37	87					0	0	1	0	0
AMBP	259	broad.mit.edu	37	9	116837253	116837253	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116837253G>A	ENST00000265132.3	-	3	586	c.324C>T	c.(322-324)ctC>ctT	p.L108L		NM_001633.3	NP_001624.1	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin precursor	108					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	11					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	ATTTGTGATAGAGAAACTTCC	0.438000													10	99					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43325361	43325361	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43325361G>A	ENST00000361428.2	-	3	768	c.691C>T	c.(691-693)Ctg>Ttg	p.L231L	ZNF318_ENST00000318149.3_Silent_p.L231L	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	231					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GATCGATGCAGGAAAGTTTCT	0.478000													28	92					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456633	5456633	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5456633G>A	ENST00000222033.4	+	1	1208	c.1131G>A	c.(1129-1131)ccG>ccA	p.P377P		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	377						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CCTCCCTACCGGGCCACCGGC	0.682000													30	97					0	0	1	0	0
PIP4K2A	5305	broad.mit.edu	37	10	22839618	22839618	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:22839618G>A	ENST00000376573.4	-	7	990	c.762C>T	c.(760-762)gtC>gtT	p.V254V	PIP4K2A_ENST00000545335.1_Silent_p.V195V|PIP4K2A_ENST00000323883.7_Silent_p.V114V	NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	254	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						TTTCCAGGAAGACCTTCTTGT	0.368000											OREG0020068	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	187					0	0	1	0	0
P2RX5-TAX1BP3	100533970	broad.mit.edu	37	17	3595085	3595085	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3595085C>T	ENST00000550383.1	-	2	329	c.141G>A	c.(139-141)tgG>tgA	p.W47*	P2RX5_ENST00000552050.1_Nonsense_Mutation_p.W11*|P2RX5_ENST00000435558.1_Nonsense_Mutation_p.W47*|P2RX5_ENST00000552276.1_Nonsense_Mutation_p.W47*|P2RX5_ENST00000225328.5_Nonsense_Mutation_p.W47*|P2RX5_ENST00000345901.3_Nonsense_Mutation_p.W47*|P2RX5_ENST00000547178.1_Nonsense_Mutation_p.W47*|P2RX5_ENST00000551178.1_Nonsense_Mutation_p.W47*																							TCAGGAACACCCATCTGTGGG	0.597000													30	77					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	420556	420556	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:420556C>T	ENST00000432829.2	+	31	4108	c.3792C>T	c.(3790-3792)ttC>ttT	p.F1264F	DOCK8_ENST00000493666.2_3'UTR|DOCK8_ENST00000382329.1_Silent_p.F799F|DOCK8_ENST00000453981.1_Silent_p.F1332F|DOCK8_ENST00000469391.1_Silent_p.F1232F	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1332					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ATCTACTTTTCATCTGTGTGT	0.418000													42	76					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54903535	54903535	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54903535C>T	ENST00000293373.6	+	6	668	c.589C>T	c.(589-591)Cac>Tac	p.H197Y	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.H147Y	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	197					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GTTTGGGCCTCACACAAAGGC	0.488000													21	187					0	0	1	0	0
PNISR	25957	broad.mit.edu	37	6	99851719	99851719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:99851719G>A	ENST00000369239.5	-	10	1346	c.1142C>T	c.(1141-1143)tCc>tTc	p.S381F	PNISR_ENST00000438806.1_Missense_Mutation_p.S381F	NM_032870.2	NP_116259.2	Q8TF01	PNISR_HUMAN	PNN-interacting serine/arginine-rich protein	381						nuclear speck				breast(2)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24						TCCAGTGAGGGAAGCCAGTGC	0.428000													10	23					0	0	1	0	0
TPPP3	51673	broad.mit.edu	37	16	67424131	67424131	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67424131G>A	ENST00000564104.1	-	3	1318	c.477C>T	c.(475-477)ggC>ggT	p.G159G	TPPP3_ENST00000562206.1_Silent_p.G159G|TPPP3_ENST00000290942.5_Silent_p.G159G|TPPP3_ENST00000393957.2_Silent_p.G159G			Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family member 3	159					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)	7		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		CGCTCACGTAGCCACTGTCGT	0.627000													15	73					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137748500	137748500	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:137748500A>T	ENST00000413152.2	+	1	39	c.39A>T	c.(37-39)aaA>aaT	p.K13N	THSD7B_ENST00000272643.3_Intron|THSD7B_ENST00000409968.1_Intron	NM_001080427.1	NP_001073896.1			thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGTATCACAAATTAGCAGGTA	0.393000													6	5					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35700223	35700223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35700223G>A	ENST00000314888.9	-	49	6978	c.6625C>T	c.(6625-6627)Cgc>Tgc	p.R2209C	TLN1_ENST00000540444.1_Missense_Mutation_p.R2097C	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	2209					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ATAGCACGGCGGCTCAGATTG	0.537000													9	79					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51900434	51900434	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51900434G>A	ENST00000371117.3	-	28	3458	c.3183C>T	c.(3181-3183)gtC>gtT	p.V1061V	PKHD1_ENST00000340994.4_Silent_p.V1061V	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1061	IPT/TIG 5.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TGCTTGTAGCGACATTGATGG	0.453000													30	117					0	0	1	0	0
DPF3	8110	broad.mit.edu	37	14	73159785	73159785	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:73159785C>T	ENST00000541685.1	-	7	753	c.742_splice	c.e7+1	p.R247_splice	DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000556509.1_Splice_Site_p.R247_splice|DPF3_ENST00000546183.1_Splice_Site_p.R257_splice	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	247					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GGCACTCACGCCTGTGGTTCT	0.552000													26	236					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171178038	171178038	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171178038C>T	ENST00000441535.1	+	9	1479	c.1362C>T	c.(1360-1362)ttC>ttT	p.F454F	FMO2_ENST00000209929.7_Silent_p.F454F|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445290.1_RNA|RP1-127D3.4_ENST00000422841.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	454					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTCTCTTGTTCAAAGATCCTA	0.502000													102	205					0	0	1	0	0
ZNF260	339324	broad.mit.edu	37	19	37005709	37005709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37005709G>A	ENST00000523638.1	-	3	1553	c.432C>T	c.(430-432)gcC>gcT	p.A144A	ZNF260_ENST00000588993.1_Silent_p.A144A|ZNF260_ENST00000593142.1_Silent_p.A144A|ZNF260_ENST00000592282.1_Silent_p.A144A	NM_001166036.1|NM_001166037.1|NM_001166038.1	NP_001159508.1|NP_001159509.1|NP_001159510.1	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	144					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)	15	Esophageal squamous(110;0.162)					TGCCGTTAAAGGCTTTGCCAC	0.393000													75	166					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628817	71628817	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71628817C>T	ENST00000377276.2	-	1	222	c.192G>A	c.(190-192)caG>caA	p.Q64Q		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	64	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CGCCGGTCTCCTGGTGCCTCA	0.607000													10	78					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141449223	141449223	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:141449223G>A	ENST00000389328.4	-	3	966	c.952C>T	c.(952-954)Cag>Tag	p.Q318*	TRAPPC9_ENST00000438773.2_Nonsense_Mutation_p.Q220*|TRAPPC9_ENST00000389327.3_Nonsense_Mutation_p.Q220*	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	220					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						AGGGAGTCCTGCAGCATCCCT	0.512000													22	107					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43006217	43006217	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43006217G>A	ENST00000587309.1	-	12	1752	c.1729C>T	c.(1729-1731)Cct>Tct	p.P577S	KIF18B_ENST00000590129.1_Missense_Mutation_p.P586S|KIF18B_ENST00000593135.1_Missense_Mutation_p.P565S|KIF18B_ENST00000438933.2_Missense_Mutation_p.P577S|KIF18B_ENST00000339151.4_Missense_Mutation_p.P577S	NM_001264573.1	NP_001251503.1			kinesin family member 18B											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				TGAGCCAGAGGTGCCCCCCTG	0.582000													8	11					0	0	1	0	0
TRIM61	391712	broad.mit.edu	37	4	165890967	165890967	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:165890967C>T	ENST00000329314.5	-	3	800	c.188G>A	c.(187-189)aGg>aAg	p.R63K		NM_001012414.2	NP_001012414.1	Q5EBN2	TRI61_HUMAN	tripartite motif containing 61	63						intracellular	zinc ion binding			NS(1)|kidney(1)|liver(1)|skin(1)|upper_aerodigestive_tract(1)	5	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.155)		TATAAATTTCCTTTCTGGACA	0.453000													15	121					0	0	1	0	0
ANKRD50	57182	broad.mit.edu	37	4	125590235	125590235	+	Silent	SNP	G	G	A	rs138487103		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:125590235G>A	ENST00000504087.1	-	4	5234	c.4197C>T	c.(4195-4197)tcC>tcT	p.S1399S	ANKRD50_ENST00000515641.1_Silent_p.S1220S	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1399										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						CTGTCTCTGAGGAAGGGTATC	0.413000													28	68					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140414484	140414484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140414484G>A	ENST00000406427.1	-	11	1305	c.969C>T	c.(967-969)gcC>gcT	p.A323A	PNPLA7_ENST00000277531.4_Silent_p.A298A	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	298			R -> Q (in dbSNP:rs11137410).		lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CGAGAGGGATGGCCTGGCTCT	0.597000													75	161					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11215925	11215925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11215925C>T	ENST00000558518.1	+	4	530	c.343C>T	c.(343-345)Cgc>Tgc	p.R115C	LDLR_ENST00000455727.2_Intron|LDLR_ENST00000558013.1_Missense_Mutation_p.R115C|LDLR_ENST00000545707.1_Intron|LDLR_ENST00000535915.1_Missense_Mutation_p.R74C|LDLR_ENST00000557933.1_Missense_Mutation_p.R115C	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	115	LDL-receptor class A 3.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GGACGAGTTTCGCTGCCACGA	0.622000													66	147					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73964105	73964105	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73964105C>T	ENST00000358602.4	-	26	4822	c.4706G>A	c.(4705-4707)aGg>aAg	p.R1569K	ANKRD17_ENST00000509867.2_Missense_Mutation_p.R1456K|ANKRD17_ENST00000330838.6_Missense_Mutation_p.R1318K	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	1569					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCTGTTTTTCCTCTTTGAACT	0.373000													43	106					0	0	1	0	0
TAGLN2	8407	broad.mit.edu	37	1	159890198	159890198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159890198G>A	ENST00000368097.4	-	2	412	c.102C>T	c.(100-102)atC>atT	p.I34I	TAGLN2_ENST00000478033.1_5'UTR|TAGLN2_ENST00000368096.1_Silent_p.I55I|TAGLN2_ENST00000320307.4_Silent_p.I34I	NM_001277223.1|NM_003564.1	NP_001264152.1|NP_003555.1	P37802	TAGL2_HUMAN	transgelin 2	34	CH.				muscle organ development	nuclear membrane|plasma membrane	protein binding			endometrium(1)|large_intestine(2)|lung(6)	9	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTGGGTGGTGATCCACTGGA	0.602000													26	78					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157959893	157959893	+	Missense_Mutation	SNP	C	C	T	rs144856548	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157959893C>T	ENST00000389413.3	-	6	743	c.640G>A	c.(640-642)Gag>Aag	p.E214K	PTPRN2_ENST00000389416.4_Missense_Mutation_p.E197K|PTPRN2_ENST00000404321.2_Missense_Mutation_p.E237K|PTPRN2_ENST00000389418.4_Missense_Mutation_p.E214K|PTPRN2_ENST00000409483.1_Missense_Mutation_p.E176K	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	214						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGGAGGTCCTCGCGGAGCTGG	0.647000													20	51					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179533882	179533882	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179533882G>A	ENST00000367615.4	-	2	389	c.321C>T	c.(319-321)ctC>ctT	p.L107L	NPHS2_ENST00000367616.4_Silent_p.L107L	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	107					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GCAGGGAAATGAGGACAAGAA	0.413000													22	53					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75051124	75051124	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75051124C>T	ENST00000310715.3	-	20	2429	c.2309G>A	c.(2308-2310)cGg>cAg	p.R770Q	TTC18_ENST00000355577.3_Missense_Mutation_p.R239Q|TTC18_ENST00000394865.1_Missense_Mutation_p.R770Q|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000401621.2_Missense_Mutation_p.R770Q|TTC18_ENST00000493787.1_5'UTR	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	770							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					CTGAAGCATCCGTGCCTGAAG	0.423000													57	112					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141779	29141779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29141779C>T	ENST00000377167.2	+	1	469	c.367C>T	c.(367-369)Cgt>Tgt	p.R123C		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						GTCATATGATCGTTATGTAGC	0.448000													94	255					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404029	20404029	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20404029C>T	ENST00000285600.4	+	1	263	c.204C>T	c.(202-204)ttC>ttT	p.F68F		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ATCTTTCTTTCATTGATATCT	0.388000													55	131					0	0	1	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130286134	130286134	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130286134G>A	ENST00000257359.6	-	4	1894	c.1188C>T	c.(1186-1188)ttC>ttT	p.F396F		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	396	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TCAGGTGGACGAACAGCGGTG	0.677000													4	9					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124756615	124756615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124756615C>T	ENST00000306534.3	-	16	3024	c.2539G>A	c.(2539-2541)Gga>Aga	p.G847R	RP11-664I21.5_ENST00000524453.1_RNA|ROBO4_ENST00000533054.1_Missense_Mutation_p.G702R	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	847					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCCACCCCTCCTCCAGTCCTG	0.662000													16	42					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91709262	91709262	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:91709262C>T	ENST00000359028.2	+	32	8076	c.7851C>T	c.(7849-7851)acC>acT	p.T2617T	AKAP9_ENST00000356239.3_Silent_p.T2605T|AKAP9_ENST00000358100.2_Silent_p.T2617T			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2617	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGCATTAACCTTGAGAATAT	0.289000			T	BRAF	papillary thyroid								43	80					0	0	1	0	0
SAP130	79595	broad.mit.edu	37	2	128753978	128753978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128753978G>A	ENST00000357702.5	-	11	1510	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F	SAP130_ENST00000259235.3_Missense_Mutation_p.S460F|SAP130_ENST00000259234.6_Missense_Mutation_p.S434F	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	460					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CCGATGTCCGGAGATGGGAAT	0.552000													9	104					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37514875	37514875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37514875C>T	ENST00000264741.5	+	3	600	c.344C>T	c.(343-345)aCc>aTc	p.T115I	ITGA9_ENST00000422441.1_Missense_Mutation_p.T115I	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	115					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TGCGGAAAGACCTGCCGGGAA	0.602000													11	48					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51160458	51160458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:51160458C>T	ENST00000414786.2	+	21	4382	c.4155C>T	c.(4153-4155)ttC>ttT	p.F1385F	SHANK3_ENST00000262795.3_Silent_p.F1415F|SHANK3_ENST00000445220.2_Silent_p.F1401F			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1415										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		ACACCTCCTTCGCTGACGGAC	0.632000													13	11					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110530483	110530483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110530483G>A	ENST00000378402.5	+	73	11881	c.11777G>A	c.(11776-11778)gGa>gAa	p.G3926E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3926					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGGTTAAAGGAACTATACCT	0.373000										HNSCC(38;0.096)			30	55					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34684295	34684295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34684295C>T	ENST00000488417.1	+	7	1850	c.1730C>T	c.(1729-1731)tCg>tTg	p.S577L	C1orf94_ENST00000373374.3_Missense_Mutation_p.S387L	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	387							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				AGGTTCGGCTCGACATCCGGA	0.448000													22	85					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15734018	15734018	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15734018C>T	ENST00000441682.2	+	0	812							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CTTCCTCACTCCCTGTGGACG	0.562000													32	58					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111744784	111744784	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:111744784G>T	ENST00000261726.6	+	11	1072	c.918G>T	c.(916-918)aaG>aaT	p.K306N		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	306						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.K306K(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TGGCCTCCAAGGACAGGGAGA	0.642000													31	77					1.61788e-16	1.62681e-16	1	1	0
RBBP8NL	140893	broad.mit.edu	37	20	60991260	60991260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60991260C>T	ENST00000252998.1	-	6	502	c.346G>A	c.(346-348)Gag>Aag	p.E116K		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		TTCAAGGTCTCGTTCTCTTCC	0.637000													7	34					0	0	1	0	0
CAMKV	79012	broad.mit.edu	37	3	49898437	49898437	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49898437C>T	ENST00000477224.1	-	7	1055	c.577G>A	c.(577-579)Ggc>Agc	p.G193S	CAMKV_ENST00000463537.1_Missense_Mutation_p.G193S|CAMKV_ENST00000296471.7_Intron|CAMKV_ENST00000467248.1_Missense_Mutation_p.G118S|CAMKV_ENST00000466940.1_Missense_Mutation_p.G150S|CAMKV_ENST00000488336.1_Missense_Mutation_p.G193S			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	193	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CGCTGCCGGCCTACCACCTCT	0.572000													16	34					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168111061	168111061	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168111061C>T	ENST00000519560.1	-	32	4015	c.3596G>A	c.(3595-3597)gGa>gAa	p.G1199E	SLIT3_ENST00000332966.8_Missense_Mutation_p.G1206E|SLIT3_ENST00000404867.3_Missense_Mutation_p.G1199E	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1199	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCATTGTCTCCTTTGTAGAG	0.582000													14	64					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9483820	9483820	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:9483820C>T	ENST00000402466.1	+	11	1442	c.674C>T	c.(673-675)cCc>cTc	p.P225L	SETD5_ENST00000402198.1_Missense_Mutation_p.P323L|SETD5_ENST00000407969.1_Missense_Mutation_p.P342L|SETD5_ENST00000302463.6_Missense_Mutation_p.P225L|SETD5_ENST00000406341.1_Missense_Mutation_p.P323L			Q9C0A6	SETD5_HUMAN	SET domain containing 5	323										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGACCATACCCCTTTGTGCTC	0.418000													7	20					0	0	1	0	0
ADAM8	101	broad.mit.edu	37	10	135086808	135086808	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:135086808C>T	ENST00000445355.3	-	6	573	c.523G>A	c.(523-525)Ggc>Agc	p.G175S	ADAM8_ENST00000415217.3_Missense_Mutation_p.G175S|ADAM8_ENST00000485491.2_Missense_Mutation_p.G136S|ADAM8_ENST00000559180.1_Intron	NM_001109.4	NP_001100.3	B4DVM6	B4DVM6_HUMAN	ADAM metallopeptidase domain 8	136					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)	17		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		AGGAGGCTGCCCAGGCTGTCG	0.711000													3	5					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55151968	55151968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55151968G>A	ENST00000414150.2	+	15	2836	c.2558G>A	c.(2557-2559)aGc>aAc	p.S853N	MROH7_ENST00000339553.5_Missense_Mutation_p.S853N|MROH7_ENST00000545244.1_Missense_Mutation_p.S421N|MROH7_ENST00000454855.2_Missense_Mutation_p.S371N|MROH7_ENST00000421030.2_Missense_Mutation_p.S853N|MROH7_ENST00000409996.1_Missense_Mutation_p.S421N|MROH7_ENST00000395690.2_Missense_Mutation_p.S853N					maestro heat-like repeat family member 7																		TCCGTCAACAGCTGCATGGGC	0.652000													12	35					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35392492	35392492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35392492C>T	ENST00000311565.4	+	8	1363	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F	PPARD_ENST00000337400.2_Silent_p.F338F|PPARD_ENST00000418635.2_Silent_p.F240F|PPARD_ENST00000444397.1_Silent_p.F338F|PPARD_ENST00000448077.2_Silent_p.F299F|PPARD_ENST00000540939.1_Silent_p.F235F|PPARD_ENST00000360694.3_Silent_p.F338F	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	338	Ligand-binding.				apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	CTGTCAAGTTCAACGCCCTGG	0.547000													28	38					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48275352	48275352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48275352G>A	ENST00000225964.5	-	8	718	c.600C>T	c.(598-600)ggC>ggT	p.G200G		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	200	Triple-helical region.		G -> V (in OI1; patient diagnosed with OI1/OI4).		axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GACCTTGGAAGCCTTGGGGAC	0.493000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta				OREG0024560	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	37					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96612497	96612497	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96612497G>A	ENST00000371321.3	+	9	1381	c.1299G>A	c.(1297-1299)cgG>cgA	p.R433R	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	433			R -> W (in allele CYP2C19*5A and allele CYP2C19*5B; loss of activity; dbSNP:rs56337013).		exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CAGGAAAACGGATTTGTGTGG	0.433000													32	94					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47717316	47717316	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47717316G>A	ENST00000360380.3	-	18	3719	c.3356C>T	c.(3355-3357)aCc>aTc	p.T1119I	STIL_ENST00000396221.2_Missense_Mutation_p.T1102I|STIL_ENST00000337817.5_Missense_Mutation_p.T1119I|STIL_ENST00000371877.3_Missense_Mutation_p.T1120I|STIL_ENST00000243182.6_Missense_Mutation_p.T1119I			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	1119					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				ATATTTTTTGGTTGCAAATGA	0.373000													71	169					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29735010	29735010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29735010G>A	ENST00000357586.2	-	16	2318	c.2132C>T	c.(2131-2133)aCc>aTc	p.T711I	AP1B1_ENST00000405198.1_Missense_Mutation_p.T711I|AP1B1_ENST00000402502.1_Missense_Mutation_p.T704I|AP1B1_ENST00000472057.1_5'UTR|AP1B1_ENST00000432560.2_Missense_Mutation_p.T704I|AP1B1_ENST00000356015.2_Missense_Mutation_p.T704I|AP1B1_ENST00000317368.7_Missense_Mutation_p.T704I|AP1B1_ENST00000415447.1_Missense_Mutation_p.T704I	NM_001127.3	NP_001118.3	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	711	Pro-rich (stalk region).				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						TCCTGACAGGGTGCCCACGCC	0.557000													64	145					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100510857	100510857	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100510857G>A	ENST00000457717.1	+	5	707	c.451G>A	c.(451-453)Ggt>Agt	p.G151S	MTTP_ENST00000265517.5_Missense_Mutation_p.G151S|MTTP_ENST00000511045.1_Missense_Mutation_p.G178S	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	151	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TATCAAGAGAGGTCTGGCTAG	0.403000													13	55					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170236609	170236609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:170236609C>T	ENST00000518525.1	+	10	1334	c.870C>T	c.(868-870)atC>atT	p.I290I	GABRP_ENST00000519385.1_Intron|GABRP_ENST00000519598.1_Silent_p.I290I|GABRP_ENST00000265294.4_Silent_p.I290I			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	290						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CACTGATGATCGGGTCCCGCA	0.517000											OREG0017032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	178					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37407092	37407092	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37407092G>A	ENST00000403892.3	-	2	1604	c.870C>T	c.(868-870)tcC>tcT	p.S290S	TST_ENST00000249042.3_Silent_p.S290S	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	290					cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						ACTTTCCCTGGGACACACGGC	0.602000													32	103					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24663358	24663358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:24663358C>T	ENST00000396475.2	+	3	371	c.72C>T	c.(70-72)ttC>ttT	p.F24F	MPP6_ENST00000222644.4_Silent_p.F24F|MPP6_ENST00000409761.1_Intron	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	24	L27 1.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						ACCTAATTTTCCTCAAGGGAA	0.348000													25	61					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215807692	215807692	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:215807692C>T	ENST00000272895.7	-	50	7612	c.7393G>A	c.(7393-7395)Gga>Aga	p.G2465R	AC072062.1_ENST00000607412.1_RNA|ABCA12_ENST00000389661.4_Missense_Mutation_p.G2147R	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2465	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TGAAACTTTCCATTCACCATA	0.398000													24	50					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55719575	55719575	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55719575C>T	ENST00000373965.2	-	24	3454	c.3060G>A	c.(3058-3060)gaG>gaA	p.E1020E	PCDH15_ENST00000395445.1_Silent_p.E1020E|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Silent_p.E1018E|PCDH15_ENST00000395433.1_Silent_p.E991E|PCDH15_ENST00000395430.1_Silent_p.E1013E|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000361849.3_Silent_p.E1013E|PCDH15_ENST00000395438.1_Silent_p.E1013E|PCDH15_ENST00000409834.1_Silent_p.E624E|PCDH15_ENST00000437009.1_Silent_p.E942E|PCDH15_ENST00000320301.6_Silent_p.E1013E|PCDH15_ENST00000395432.2_Silent_p.E976E	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1013	Cadherin 9.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACATCACAGGCTCCCCATCAT	0.398000										HNSCC(58;0.16)			24	55					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118307871	118307871	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:118307871G>A	ENST00000369221.2	+	4	229		c.e4-1		PNLIP_ENST00000470562.1_Splice_Site	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGTCTAAACAGGAAGTTGCCG	0.388000													43	112					0	0	1	0	0
KCND3	3752	broad.mit.edu	37	1	112525239	112525239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112525239C>T	ENST00000369697.1	-	1	179	c.110G>A	c.(109-111)cGg>cAg	p.R37Q	KCND3_ENST00000315987.2_Missense_Mutation_p.R37Q|KCND3_ENST00000302127.4_Missense_Mutation_p.R37Q			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	37						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		CTCATCCTGCCGCTTGTTCTT	0.682000													11	53					0	0	1	0	0
MARC1	64757	broad.mit.edu	37	1	220970065	220970065	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:220970065C>T	ENST00000366910.5	+	3	716	c.530C>T	c.(529-531)cCc>cTc	p.P177L	MARC1_ENST00000496110.1_3'UTR	NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	177							molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										AAGTCACAGCCCTACCGCCTG	0.607000													12	35					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90500477	90500477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90500477C>T	ENST00000325643.5	+	4	1141	c.1075C>T	c.(1075-1077)Cct>Tct	p.P359S		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		ATTCATCCACCCTGACGTGCA	0.582000													6	67					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640386	57640386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57640386G>A	ENST00000254181.4	+	4	797	c.343G>A	c.(343-345)Gat>Aat	p.D115N	USP29_ENST00000598197.1_Missense_Mutation_p.D115N	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	115					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAAATCTGATGATGATTGGAG	0.353000													20	69					0	0	1	0	0
INHBC	3626	broad.mit.edu	37	12	57843461	57843461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57843461G>A	ENST00000309668.2	+	2	842	c.715G>A	c.(715-717)Gac>Aac	p.D239N	INHBC_ENST00000550133.1_Intron	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	239					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						ACGAGGCATCGACTGCCAAGG	0.587000													15	26					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48667926	48667926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48667926C>T	ENST00000352832.5	+	10	2768	c.2396C>T	c.(2395-2397)cCc>cTc	p.P799L	CACNA1G_ENST00000512389.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000507336.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000507609.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000354983.4_Missense_Mutation_p.P799L|CACNA1G_ENST00000503485.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000507896.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000358244.5_Missense_Mutation_p.P799L|CACNA1G_ENST00000510115.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000510366.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000502264.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000429973.2_Missense_Mutation_p.P799L|CACNA1G_ENST00000416767.4_Missense_Mutation_p.P799L|CACNA1G_ENST00000360761.4_Missense_Mutation_p.P799L|CACNA1G_ENST00000515765.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000515411.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000442258.2_Missense_Mutation_p.P799L|CACNA1G_ENST00000515165.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000505165.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000359106.5_Missense_Mutation_p.P799L|CACNA1G_ENST00000514717.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000514181.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000514079.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000513964.1_Missense_Mutation_p.P799L|CACNA1G_ENST00000507510.2_Missense_Mutation_p.P799L|CACNA1G_ENST00000513689.2_Missense_Mutation_p.P799L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	799					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTGTATGGTCCCTTTGGCTAC	0.517000													8	40					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8206855	8206855	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8206855G>A	ENST00000600128.1	-	7	1122	c.708C>T	c.(706-708)ttC>ttT	p.F236F	FBN3_ENST00000601739.1_Silent_p.F236F|FBN3_ENST00000270509.2_Silent_p.F236F			Q75N90	FBN3_HUMAN	fibrillin 3	236	TB 1.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TATTGGGGATGAAGCCGCGGC	0.632000													11	39					0	0	1	0	0
ZNF268	10795	broad.mit.edu	37	12	133780482	133780482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:133780482C>T	ENST00000536435.2	+	6	2540	c.2210C>T	c.(2209-2211)tCa>tTa	p.S737L	ZNF268_ENST00000541009.2_3'UTR|ZNF268_ENST00000228289.5_Missense_Mutation_p.S737L|ZNF268_ENST00000537565.1_Missense_Mutation_p.S576L|ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000542986.2_3'UTR	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	737						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AGTTTCAATTCACAACTCATT	0.408000													3	16					0	0	1	0	0
AGO1	26523	broad.mit.edu	37	1	36358229	36358229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36358229G>A	ENST00000373204.4	+	3	494	c.281G>A	c.(280-282)gGa>gAa	p.G94E	AGO1_ENST00000373206.1_Missense_Mutation_p.G19E	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GTGTATGATGGAAAGAAGAAC	0.527000													32	60					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167060643	167060643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167060643C>T	ENST00000375387.4	-	26	4939	c.4599G>A	c.(4597-4599)atG>atA	p.M1533I	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.M1521I|SCN9A_ENST00000409435.1_Missense_Mutation_p.M1532I|SCN9A_ENST00000303354.6_Missense_Mutation_p.M1533I			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1532						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TTTCTACCATCATGGTTACCA	0.343000													12	53					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23391470	23391470	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23391470G>A	ENST00000343070.2	+	12	1698	c.1522G>A	c.(1522-1524)Gaa>Aaa	p.E508K	SCNN1B_ENST00000568923.1_Missense_Mutation_p.E481K|SCNN1B_ENST00000568085.1_Missense_Mutation_p.E472K|SCNN1B_ENST00000307331.5_Missense_Mutation_p.E553K	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	508					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TCGCACCATTGAAGAATCAGC	0.542000													19	81					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585375	82585375	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82585375C>T	ENST00000423517.2	-	5	5231	c.4894G>A	c.(4894-4896)Gaa>Aaa	p.E1632K	PCLO_ENST00000333891.8_Missense_Mutation_p.E1632K	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1563					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.E1632K(2)|p.E1563K(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCATCGTCTTCATCATGCCAT	0.428000													83	200					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124459274	124459274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124459274C>T	ENST00000329446.4	-	1	64	c.33G>A	c.(31-33)agG>agA	p.R11R		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	11										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				GTTTTTCAATCCTCTGACAGT	0.428000													22	64					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	134980930	134980930	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134980930C>T	ENST00000304613.3	+	2	169	c.148C>T	c.(148-150)Ctc>Ttc	p.L50F	KNDC1_ENST00000530127.1_3'UTR|KNDC1_ENST00000368572.2_Missense_Mutation_p.L50F|KNDC1_ENST00000368571.2_5'UTR			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	50	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGACCGCGGCCTCAGCGAGCA	0.711000													4	10					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46704372	46704372	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46704372C>T	ENST00000454366.1	+	4	506	c.294C>T	c.(292-294)ttC>ttT	p.F98F		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	79					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		GGGAGAAGTTCGTGGAGGTGT	0.567000													55	151					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073561	9073561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9073561C>T	ENST00000397910.4	-	3	14088	c.13885G>A	c.(13885-13887)Gct>Act	p.A4629T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4631	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCAGTAATAGCCCCCACAGAC	0.458000													18	62					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27296616	27296616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27296616C>T	ENST00000397501.1	+	24	2520	c.1712C>T	c.(1711-1713)tCc>tTc	p.S571F	PTK2B_ENST00000517339.1_Missense_Mutation_p.S571F|PTK2B_ENST00000346049.5_Missense_Mutation_p.S571F|PTK2B_ENST00000338238.4_Missense_Mutation_p.S571F|PTK2B_ENST00000397497.4_Missense_Mutation_p.S317F|PTK2B_ENST00000544172.1_Missense_Mutation_p.S571F|PTK2B_ENST00000420218.2_Missense_Mutation_p.S571F	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	571	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TTTGGTCTTTCCCGGTACATT	0.557000													29	78					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	17990868	17990868	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17990868G>A	ENST00000262608.8	+	7	771	c.771G>A	c.(769-771)aaG>aaA	p.K257K	CECR2_ENST00000400573.4_Silent_p.K276K|CECR2_ENST00000342247.5_Intron|CECR2_ENST00000400585.2_Silent_p.K135K	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	298					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		AGCGCACAAAGGCAGAGTTGC	0.493000													14	174					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73615396	73615396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73615396C>T	ENST00000261917.3	-	8	4031	c.3038G>A	c.(3037-3039)gGg>gAg	p.G1013E		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	1013	Pro-rich.				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		AGGGGAAGCCCCCCCAGAGGC	0.711000													5	9					0	0	1	0	0
FAM78B	149297	broad.mit.edu	37	1	166135292	166135292	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:166135292G>A	ENST00000338353.3	-	2	783	c.194C>T	c.(193-195)aCc>aTc	p.T65I	FAM78B_ENST00000354422.3_Missense_Mutation_p.T65I			Q5VT40	FA78B_HUMAN	family with sequence similarity 78, member B	65										central_nervous_system(1)|endometrium(5)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					CACCACCCAGGTCTCGTGGCG	0.652000													12	25					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73056937	73056937	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:73056937G>A	ENST00000261180.4	+	19	3133	c.3037G>A	c.(3037-3039)Gag>Aag	p.E1013K		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	1013					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding	p.E1013Q(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTACCAAGACGAGCTTTTCCA	0.393000													12	36					0	0	1	0	0
DCN	1634	broad.mit.edu	37	12	91572281	91572281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91572281C>T	ENST00000551354.1	-	2	253	c.49G>A	c.(49-51)Gga>Aga	p.G17R	DCN_ENST00000420120.2_Missense_Mutation_p.G17R|DCN_ENST00000052754.5_Missense_Mutation_p.G17R|DCN_ENST00000425043.1_Missense_Mutation_p.G17R|DCN_ENST00000228329.5_Missense_Mutation_p.G17R|DCN_ENST00000547568.2_Missense_Mutation_p.G17R|DCN_ENST00000550099.1_Missense_Mutation_p.G17R|DCN_ENST00000546745.1_Missense_Mutation_p.G17R|DCN_ENST00000393155.1_Missense_Mutation_p.G17R|DCN_ENST00000546370.1_Missense_Mutation_p.G17R|DCN_ENST00000456569.2_Missense_Mutation_p.G17R|DCN_ENST00000552962.1_Missense_Mutation_p.G17R|DCN_ENST00000441303.2_Missense_Mutation_p.G17R|DCN_ENST00000303320.3_Missense_Mutation_p.G17R			P07585	PGS2_HUMAN	decorin	17					organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						TGAAACGGTCCAGCCCAGGAA	0.473000											OREG0022021	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	58					0	0	1	0	0
C15orf32	145858	broad.mit.edu	37	15	93015479	93015479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93015479C>T	ENST00000333334.2	+	1	596	c.101C>T	c.(100-102)aCt>aTt	p.T34I	C15orf32_ENST00000556865.1_Missense_Mutation_p.T34I	NM_153040.2	NP_694585.1	Q32M92	CO032_HUMAN	chromosome 15 open reading frame 32	34										endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	12	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			AACACCAAGACTTCCCCAAGA	0.537000													74	93					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121326189	121326189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:121326189G>A	ENST00000297848.3	+	38	4744	c.4474G>A	c.(4474-4476)Ggt>Agt	p.G1492S	COL14A1_ENST00000247781.3_Missense_Mutation_p.G1397S|COL14A1_ENST00000309791.4_Missense_Mutation_p.G1492S	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1492	Triple-helical region 1 (COL2).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGCCCTCGGGGTGAAATTGG	0.473000													39	157					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175598335	175598335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175598335G>A	ENST00000274093.3	-	7	1323	c.821C>T	c.(820-822)tCa>tTa	p.S274L	GLRA3_ENST00000340217.5_Missense_Mutation_p.S274L	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	274					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GATCCAGAATGAAACCCAGGA	0.478000													11	33					0	0	1	0	0
AKR7L	246181	broad.mit.edu	37	1	19595801	19595801	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19595801G>A	ENST00000420396.2	-	0	507				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						GAGTCCCAAAGAAGCGGCCCA	0.592000													26	84					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233322985	233322985	+	Silent	SNP	G	G	A	rs143128875		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233322985G>A	ENST00000295463.3	+	9	1127	c.1050G>A	c.(1048-1050)gcG>gcA	p.A350A		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	350					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCACTGAGGCGGTCATGTTCG	0.627000													23	51					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55368262	55368262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55368262G>A	ENST00000449076.1	-	2	217	c.85C>T	c.(85-87)Cta>Tta	p.L29L	TESPA1_ENST00000316577.8_Silent_p.L29L	NM_001136030.2	NP_001129502.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	29																	TCCTCTTCTAGGACCTGGGTC	0.612000													6	11					0	0	1	0	0
ADORA1	134	broad.mit.edu	37	1	203134472	203134472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203134472C>T	ENST00000367236.4	+	3	1346	c.425C>T	c.(424-426)cCt>cTt	p.P142L	ADORA1_ENST00000337894.4_Missense_Mutation_p.P142L|ADORA1_ENST00000309502.3_Missense_Mutation_p.P142L|ADORA1_ENST00000367235.1_3'UTR|ADORA1_ENST00000472535.1_3'UTR	NM_001048230.1	NP_001041695.1	P30542	AA1R_HUMAN	adenosine A1 receptor	142					induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(9)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GGACTGACCCCTATGTTTGGC	0.647000													23	31					0	0	1	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209950792	209950792	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209950792G>A	ENST00000367024.1	+	12	1665	c.1149G>A	c.(1147-1149)ggG>ggA	p.G383G	TRAF3IP3_ENST00000477431.1_Silent_p.G119G|TRAF3IP3_ENST00000400959.3_Silent_p.G363G|TRAF3IP3_ENST00000367023.1_Silent_p.G119G|TRAF3IP3_ENST00000367025.3_Silent_p.G383G|TRAF3IP3_ENST00000367026.3_Silent_p.G363G|TRAF3IP3_ENST00000010338.4_Silent_p.G363G			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	383						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		GCCTGCAAGGGGACAGAGACC	0.522000													14	48					0	0	1	0	0
ZBED6CL	113763	broad.mit.edu	37	7	150028044	150028044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150028044C>T	ENST00000343855.4	+	1	1107	c.551C>T	c.(550-552)tCg>tTg	p.S184L	LRRC61_ENST00000323078.7_Intron|LRRC61_ENST00000493307.1_Intron|LRRC61_ENST00000359623.4_Intron	NM_138434.2	NP_612443.1			ZBED6 C-terminal like																		AGCGGGGGCTCGCTGTCCACC	0.622000													12	19					0	0	1	0	0
HELQ	113510	broad.mit.edu	37	4	84337894	84337894	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:84337894G>A	ENST00000295488.3	-	17	3350	c.3188C>T	c.(3187-3189)tCa>tTa	p.S1063L	HELQ_ENST00000510985.1_Missense_Mutation_p.S996L	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	1063							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						CTTTGCTGATGAAACAATTTG	0.343000								Other identified genes with known or suspected DNA repair function					16	247					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533045	169533045	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169533045G>A	ENST00000449804.2	+	1	129	c.84G>A	c.(82-84)atG>atA	p.M28I	FOXI1_ENST00000306268.6_Missense_Mutation_p.M28I	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	28	Pro-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCCGAGATGAACCTCTACT	0.697000									Pendred syndrome				16	45					0	0	1	0	0
BOD1L2	284257	broad.mit.edu	37	18	54814920	54814920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:54814920C>T	ENST00000585477.1	+	1	628	c.377C>T	c.(376-378)cCa>cTa	p.P126L		NM_001257964.1	NP_001244893.1			biorientation of chromosomes in cell division 1-like 2																		GTGGTGGATCCAAAACTAAAC	0.502000													20	50					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430867	43430867	+	RNA	SNP	C	C	T	rs145405049		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43430867C>T	ENST00000446844.3	-	0	800				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TGGGCAGCTTCGCTGTGTGAA	0.473000													59	282					0	0	1	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208842195	208842195	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:208842195G>T	ENST00000457206.1	-	3	1153	c.726C>A	c.(724-726)ttC>ttA	p.F242L	PLEKHM3_ENST00000389247.4_Missense_Mutation_p.F242L|PLEKHM3_ENST00000427836.2_Missense_Mutation_p.F242L			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	242	PH 1.				intracellular signal transduction		metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CGAGGCTGTAGAAGTATAAGT	0.448000													41	135					2.37825e-27	2.39435e-27	1	1	0
ELFN2	114794	broad.mit.edu	37	22	37769836	37769836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37769836G>A	ENST00000402918.1	-	3	2524	c.1739C>T	c.(1738-1740)tCc>tTc	p.S580F	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Missense_Mutation_p.S580F	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	580						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					TGCAGGGAGGGACTGGCACTC	0.652000													11	26					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206320265	206320265	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206320265C>T	ENST00000361052.3	+	4	526	c.408C>T	c.(406-408)tcC>tcT	p.S136S	CTSE_ENST00000360218.2_Silent_p.S136S|CTSE_ENST00000468617.1_3'UTR|CTSE_ENST00000358184.2_Silent_p.S136S|CTSE_ENST00000432969.2_Silent_p.S61S			P14091	CATE_HUMAN	cathepsin E	136					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			AATCTTTCTCCATTCAGTATG	0.517000													26	65					0	0	1	0	0
STOX1	219736	broad.mit.edu	37	10	70644918	70644918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70644918C>T	ENST00000298596.6	+	3	1449	c.1366C>T	c.(1366-1368)Cct>Tct	p.P456S	STOX1_ENST00000399165.4_Intron|STOX1_ENST00000399162.2_Intron|STOX1_ENST00000399169.4_Missense_Mutation_p.P456S|STOX1_ENST00000421961.2_Missense_Mutation_p.P346S	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	456						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						CCCCAAGCTCCCTGCTACACA	0.478000													50	96					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110681737	110681737	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:110681737C>T	ENST00000394634.2	-	5	921	c.714G>A	c.(712-714)atG>atA	p.M238I	CFI_ENST00000512148.1_Missense_Mutation_p.M238I|CFI_ENST00000394635.3_Missense_Mutation_p.M238I	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	238	LDL-receptor class A 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CACAGGCTTTCATCTGAGAAA	0.348000													30	68					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13659684	13659684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13659684G>A	ENST00000404922.3	+	6	1957	c.1838G>A	c.(1837-1839)gGa>gAa	p.G613E	FBLN2_ENST00000295760.7_Missense_Mutation_p.G613E|FBLN2_ENST00000535798.1_Missense_Mutation_p.G639E|FBLN2_ENST00000492059.1_Missense_Mutation_p.G613E	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	613	EGF-like 1; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CTCCTCCCGGGAGAGCTGTGC	0.632000													20	103					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116931709	116931709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116931709G>A	ENST00000356083.3	+	3	2265	c.1874G>A	c.(1873-1875)gGg>gAg	p.G625E		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	625	Collagen-like 1.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CTGCTGATGGGGCCTCCGGGA	0.632000													11	68					0	0	1	0	0
FAM129B	64855	broad.mit.edu	37	9	130286073	130286073	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130286073G>A	ENST00000373312.3	-	5	687	c.474C>T	c.(472-474)ttC>ttT	p.F158F	FAM129B_ENST00000468379.1_Intron|FAM129B_ENST00000373314.3_Silent_p.F145F	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	158	PH.						protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						GGATGAGCGGGAACTGTGTGG	0.602000											OREG0019507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	92					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4797517	4797517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4797517G>A	ENST00000299320.5	+	9	1932	c.1454G>A	c.(1453-1455)gGg>gAg	p.G485E	C16orf71_ENST00000590191.1_Missense_Mutation_p.G502E|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	485										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						TGTGCCAAGGGGCAGAGCGCC	0.672000													11	34					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51900495	51900495	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51900495C>T	ENST00000371117.3	-	28	3397	c.3122G>A	c.(3121-3123)gGc>gAc	p.G1041D	PKHD1_ENST00000340994.4_Missense_Mutation_p.G1041D	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1041	IPT/TIG 5.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CAAACTAGAGCCTCGGATGGT	0.428000													26	52					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31483684	31483684	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31483684T>A	ENST00000322054.5	+	4	1096	c.811T>A	c.(811-813)Ttt>Att	p.F271I	EHD3_ENST00000541626.1_Intron	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	271					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					CCGGAAGCTCTTTGAGGCTGA	0.592000													28	107					0	0	1	0	0
LOC401127	401127	broad.mit.edu	37	4	39482951	39482951	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39482951G>A	ENST00000513652.1	+	0	958																											AACTTCAGACGAAAGAGATTG	0.438000													17	62					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158450377	158450377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158450377C>T	ENST00000368152.1	+	1	710	c.710C>T	c.(709-711)tCt>tTt	p.S237F	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					ATCTGTGTTTCTTATCTCTGC	0.433000													29	112					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43788174	43788174	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43788174C>T	ENST00000261488.6	-	17	2461	c.1884G>A	c.(1882-1884)ctG>ctA	p.L628L	ENOX1_ENST00000412891.1_Silent_p.L628L	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	628					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		ATCTTTTTTCCAGCGTGGCTC	0.448000													28	88					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39883959	39883959	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39883959G>A	ENST00000341184.6	+	2	822	c.607G>A	c.(607-609)Gag>Aag	p.E203K		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	203					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GGTGCCCAGGGAGGTGCCGCG	0.677000													7	18					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919074	12919074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12919074G>A	ENST00000240189.2	+	2	297	c.210G>A	c.(208-210)atG>atA	p.M70I		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	70										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TATCGCTGATGAAGACGCTTC	0.567000													87	295					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39202124	39202124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39202124G>A	ENST00000351578.6	-	2	1129	c.939C>T	c.(937-939)ttC>ttT	p.F313F	FYB_ENST00000515010.1_Silent_p.F313F|FYB_ENST00000505428.1_Silent_p.F313F|FYB_ENST00000540520.1_Silent_p.F323F|FYB_ENST00000512982.1_Silent_p.F313F	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	313					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			GGGCCTTAGGGAACCTGGCAG	0.498000													27	67					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84523312	84523312	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84523312G>A	ENST00000360700.4	+	8	1953	c.1067G>A	c.(1066-1068)aGa>aAa	p.R356K	ZNF711_ENST00000542798.1_Missense_Mutation_p.R152K|ZNF711_ENST00000373165.3_Missense_Mutation_p.R310K|ZNF711_ENST00000276123.3_Missense_Mutation_p.R310K|ZNF711_ENST00000395402.1_Intron			Q9Y462	ZN711_HUMAN	zinc finger protein 711	310					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GATGAAAGAAGAGTTTCCCGA	0.303000													5	13					0	0	1	0	0
FOXC2	2303	broad.mit.edu	37	16	86601587	86601587	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:86601587G>A	ENST00000320354.4	+	1	731	c.646G>A	c.(646-648)Gag>Aag	p.E216K		NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	216					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						GATCAAGAGCGAGGCGGCGTC	0.756000									Late-onset Hereditary Lymphedema				8	12					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111304210	111304210	+	Silent	SNP	G	G	A	rs139540088	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111304210G>A	ENST00000352690.4	+	5	1032	c.792G>A	c.(790-792)acG>acA	p.T264T	CD96_ENST00000283285.5_Silent_p.T280T|CD96_ENST00000438817.2_Silent_p.T264T	NM_005816.4	NP_005807.1	P40200	TACT_HUMAN	CD96 molecule	280					cell adhesion|immune response|regulation of immune response	integral to plasma membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(4)|liver(2)|lung(14)|skin(5)	35						ATAACTCCACGGATGTCTTGG	0.408000									Opitz Trigonocephaly syndrome				20	49					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914910	46914910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46914910C>T	ENST00000307522.3	-	1	1931	c.1158G>A	c.(1156-1158)gaG>gaA	p.E386E		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	386						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		TATCTGCAGCCTCTTCCCTGT	0.577000													20	237					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142186765	142186765	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142186765G>A	ENST00000519811.1	+	15	2681	c.2611G>A	c.(2611-2613)Gaa>Aaa	p.E871K	DENND3_ENST00000424248.1_Missense_Mutation_p.E739K|DENND3_ENST00000262585.2_Missense_Mutation_p.E791K			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	791										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCCAAGAAAGAAGTCTTCGA	0.488000													10	89					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815653	158815653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158815653G>A	ENST00000368141.4	+	5	1108	c.847G>A	c.(847-849)Gca>Aca	p.A283T		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	283	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					AATAAAGGAAGCATCATCTGT	0.343000													30	65					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98528268	98528268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98528268C>T	ENST00000359863.4	+	25	3615	c.3406C>T	c.(3406-3408)Ccc>Tcc	p.P1136S	TRRAP_ENST00000355540.3_Missense_Mutation_p.P1136S|TRRAP_ENST00000446306.3_Missense_Mutation_p.P1135S	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1136					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTGCCAGCTGCCCCTGTTTTC	0.483000													97	210					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59410955	59410955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:59410955G>A	ENST00000301645.3	-	2	291	c.154C>T	c.(154-156)Cct>Tct	p.P52S		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	52					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AACTCAAGAGGATTGGCACCA	0.418000									Neonatal Giant Cell Hepatitis				57	148					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72857095	72857095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72857095G>A	ENST00000339594.4	-	18	4392	c.4054C>T	c.(4054-4056)Ctc>Ttc	p.L1352F	BAZ1B_ENST00000404251.1_Missense_Mutation_p.L1352F	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1352					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				ATCTTGTGGAGGATCTCTTCA	0.532000													21	58					0	0	1	0	0
KRT35	3886	broad.mit.edu	37	17	39637034	39637034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39637034C>T	ENST00000246639.2	-	1	358	c.226G>A	c.(226-228)Gac>Aac	p.D76N	KRT35_ENST00000393989.1_Missense_Mutation_p.D106N			Q92764	KRT35_HUMAN	keratin 35	106	Head.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.000286)				GCCAGGCGGTCGTTCAGGGAT	0.637000													50	48					0	0	1	0	0
GPR111	222611	broad.mit.edu	37	6	47650116	47650116	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47650116C>T	ENST00000398742.2	+	5	1666	c.1617C>T	c.(1615-1617)ttC>ttT	p.F539F	GPR111_ENST00000507065.1_Silent_p.F539F|GPR111_ENST00000296862.1_Silent_p.F607F			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	607					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						TCCTGGCCTTCGTGATCCCAG	0.537000													12	36					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100155313	100155313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:100155313C>T	ENST00000263174.4	+	7	1872	c.1497C>T	c.(1495-1497)ccC>ccT	p.P499P	PALMD_ENST00000605497.1_Silent_p.P499P	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	499					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		ATAAATCCCCCCACAAAAATT	0.463000													23	59					0	0	1	0	0
AGAP7	653268	broad.mit.edu	37	10	51465237	51465237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:51465237C>T	ENST00000374095.5	-	7	1344	c.1219G>A	c.(1219-1221)Gag>Aag	p.E407K		NM_001077685.1	NP_001071153.1	Q5VUJ5	AGAP7_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	407	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	11						GCATCCCGCTCCTCATATGTC	0.512000													48	145					0	0	1	0	0
OR10A2	341276	broad.mit.edu	37	11	6891435	6891435	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6891435C>T	ENST00000307322.4	+	1	512	c.450C>T	c.(448-450)ctC>ctT	p.L150L		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCACATGGCTCTTCAGTTTTC	0.532000													62	153					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89999523	89999523	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89999523C>T	ENST00000405460.2	+	35	8293	c.8197C>T	c.(8197-8199)Cga>Tga	p.R2733*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2733					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTCCCTGGTCGAGGAAATGT	0.318000													9	21					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21793123	21793123	+	Silent	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21793123A>C	ENST00000206660.6	+	14	2109	c.2109A>C	c.(2107-2109)atA>atC	p.I703I	RPGRIP1_ENST00000556336.1_Intron|RPGRIP1_ENST00000382933.4_Intron|RPGRIP1_ENST00000400017.2_Silent_p.I703I|RPGRIP1_ENST00000557771.1_Silent_p.I665I|RPGRIP1_ENST00000307974.4_Silent_p.I62I|RPGRIP1_ENST00000553500.1_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	703					response to stimulus|visual perception	cilium		p.I703I(1)|p.I319I(1)		breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GGCTTGACATACACCAGGCCA	0.532000													50	128					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3267122	3267122	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3267122C>T	ENST00000520002.1	-	14	2125	c.1570G>A	c.(1570-1572)Gaa>Aaa	p.E524K	CSMD1_ENST00000542608.1_Missense_Mutation_p.E523K|CSMD1_ENST00000539096.1_Missense_Mutation_p.E523K|CSMD1_ENST00000537824.1_Missense_Mutation_p.E523K|CSMD1_ENST00000602723.1_Missense_Mutation_p.E524K|CSMD1_ENST00000400186.3_Missense_Mutation_p.E524K|CSMD1_ENST00000602557.1_Missense_Mutation_p.E524K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	524						integral to membrane		p.E252K(1)|p.E523K(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTCCCTTTTCAATTTCTGAA	0.443000													4	13					0	0	1	0	0
SRRM1	10250	broad.mit.edu	37	1	24995781	24995781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24995781C>T	ENST00000323848.9	+	14	2222	c.1907C>T	c.(1906-1908)tCc>tTc	p.S636F	SRRM1_ENST00000479034.1_3'UTR|SRRM1_ENST00000447431.2_Missense_Mutation_p.S648F|SRRM1_ENST00000374389.4_Missense_Mutation_p.S645F	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	636	Arg-rich.|Necessary for speckles and matrix localization.|Pro-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CGGCGGGTCTCCCATTCTCCA	0.532000													43	112					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20702496	20702496	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20702496C>T	ENST00000307493.4	-	1	82	c.15G>A	c.(13-15)atG>atA	p.M5I	ACSM1_ENST00000520010.1_Missense_Mutation_p.M5I|ACSM1_ENST00000219151.4_5'UTR	NM_052956.2	NP_443188.2	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	5					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TCCGGAACCTCATTAGCCACT	0.527000													46	121					0	0	1	0	0
LANCL2	55915	broad.mit.edu	37	7	55467766	55467766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55467766C>T	ENST00000254770.2	+	4	1225	c.647C>T	c.(646-648)cCa>cTa	p.P216L	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	216					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			GAGATAGGTCCAGGCACCGTG	0.463000													39	116					0	0	1	0	0
HSD3B2	3284	broad.mit.edu	37	1	119958174	119958174	+	Silent	SNP	G	G	A	rs111333222	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119958174G>A	ENST00000543831.1	+	2	381	c.132G>A	c.(130-132)gaG>gaA	p.E44E	HSD3B2_ENST00000471656.1_3'UTR|HSD3B2_ENST00000369416.3_Silent_p.E44E	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	44					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	AATTGAGAGAGGAATTTTCTA	0.498000													41	102					0	0	1	0	0
IGHV3-15	28448	broad.mit.edu	37	14	106610738	106610738	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106610738G>A	ENST00000390603.2	-	0	114																											TTTTAAAATAGCAGCAAGGAA	0.448000													43	158					0	0	1	0	0
OR52E2	119678	broad.mit.edu	37	11	5080723	5080723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5080723G>A	ENST00000321522.2	-	1	134	c.135C>T	c.(133-135)ttC>ttT	p.F45F		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTAGAATAGTGAAGTTCCCTA	0.507000													11	57					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760574	19760574	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19760574G>A	ENST00000357324.6	-	18	2537	c.2511C>T	c.(2509-2511)ttC>ttT	p.F837F	ATP13A1_ENST00000291503.5_Silent_p.F719F	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	837					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CCACACGGGCGAACACCTGCA	0.672000													10	63					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29430209	29430209	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29430209G>A	ENST00000377136.1	+	4	1128	c.663G>A	c.(661-663)caG>caA	p.Q221Q	OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377133.1_Silent_p.Q221Q|OR2H1_ENST00000442615.1_Silent_p.Q221Q|OR2H1_ENST00000396792.2_Silent_p.Q221Q|OR2H1_ENST00000377132.1_Silent_p.Q221Q			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						CCACTGCCCAGGCAGTGCTGA	0.532000													62	171					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21145707	21145707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21145707G>A	ENST00000261383.3	-	7	954	c.955C>T	c.(955-957)Cct>Tct	p.P319S	DNAH3_ENST00000415178.1_Missense_Mutation_p.P319S	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	319	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ACTCTTTGAGGAAACAAGCGG	0.527000													34	127					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33586667	33586667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33586667G>A	ENST00000262873.7	+	33	4357	c.4265G>A	c.(4264-4266)aGc>aAc	p.S1422N		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1380						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CAGTGGAGGAGCAAGTACGAA	0.627000													12	46					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3889577	3889577	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3889577C>T	ENST00000520002.1	-	4	1015	c.460G>A	c.(460-462)Gga>Aga	p.G154R	CSMD1_ENST00000542608.1_Missense_Mutation_p.G154R|CSMD1_ENST00000539096.1_Missense_Mutation_p.G154R|CSMD1_ENST00000537824.1_Missense_Mutation_p.G154R|CSMD1_ENST00000602723.1_Missense_Mutation_p.G154R|CSMD1_ENST00000400186.3_Missense_Mutation_p.G154R|CSMD1_ENST00000602557.1_Missense_Mutation_p.G154R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	154	Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCAGAACTCCTTTCAGGATT	0.448000													16	45					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62189529	62189529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:62189529G>A	ENST00000474889.1	+	12	2437	c.2060G>A	c.(2059-2061)gGg>gAg	p.G687E	PTPRG_ENST00000295874.10_Missense_Mutation_p.G687E	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	687					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CAGTATGCAGGGAGTGATCCC	0.587000													22	58					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86591475	86591475	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86591475C>T	ENST00000370571.2	-	3	910	c.544G>A	c.(544-546)Gga>Aga	p.G182R	COL24A1_ENST00000436319.1_Missense_Mutation_p.G182R	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	182	Laminin G-like.|TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TATTTCTTTCCACACTCAACA	0.343000													6	36					0	0	1	0	0
TBC1D4	9882	broad.mit.edu	37	13	75898440	75898440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:75898440G>A	ENST00000377636.3	-	11	2477	c.2131C>T	c.(2131-2133)Ccc>Tcc	p.P711S	TBC1D4_ENST00000377625.2_Intron|TBC1D4_ENST00000425511.1_5'UTR|TBC1D4_ENST00000431480.2_Missense_Mutation_p.P711S	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	711	Ser-rich.					cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AGGAAAGAGGGGGCAGTGAAG	0.453000													23	76					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67915583	67915583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67915583C>T	ENST00000358933.5	+	22	3078	c.2839C>T	c.(2839-2841)Cct>Tct	p.P947S		NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	947					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		GGCAGAGCCCCCTGAGGACTG	0.607000													14	40					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131521621	131521621	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131521621G>A	ENST00000423981.1	+	2	2086	c.1976G>A	c.(1975-1977)aGg>aAg	p.R659K	AMER3_ENST00000321420.4_Missense_Mutation_p.R659K	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GGCCCCTGGAGGCCAGGTCAC	0.632000													5	13					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30898673	30898673	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30898673C>T	ENST00000375712.3	+	2	1260	c.1093C>T	c.(1093-1095)Ctc>Ttc	p.L365F	KIF3B_ENST00000418717.2_Missense_Mutation_p.L53F	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	365					anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GATTGCTCGGCTCAAGGCCCA	0.557000													9	76					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364688	5364688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5364688G>A	ENST00000300773.2	-	1	121	c.67C>T	c.(67-69)Cac>Tac	p.H23Y	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAAATCCAGTGATGAGCTTCC	0.433000													12	43					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49867482	49867482	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49867482G>A	ENST00000331456.2	-	12	1170	c.1057C>T	c.(1057-1059)Ccc>Tcc	p.P353S	TRAIP_ENST00000469027.1_Missense_Mutation_p.P198S	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	353	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ATCTTCTTGGGGACATCCTGA	0.537000													35	111					0	0	1	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28119655	28119655	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28119655C>T	ENST00000330236.6	+	4	776	c.592C>T	c.(592-594)Cag>Tag	p.Q198*	ZKSCAN8_ENST00000457389.2_Nonsense_Mutation_p.Q198*	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		TACTCGTTCCCAGAAAGGAAG	0.527000													37	76					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17015315	17015315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17015315C>T	ENST00000443236.1	-	31	4247	c.4216G>A	c.(4216-4218)Ggc>Agc	p.G1406S		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1359						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						AAGAATGTGCCCTTGTCCACG	0.582000													33	74					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122759828	122759828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:122759828G>A	ENST00000245838.8	-	25	3023	c.2992C>T	c.(2992-2994)Cgt>Tgt	p.R998C	THOC2_ENST00000491737.1_Missense_Mutation_p.R883C|THOC2_ENST00000355725.4_Missense_Mutation_p.R998C	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	998					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						TCAACAAAACGAGCACAGTAA	0.323000													30	33					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127340602	127340602	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127340602C>T	ENST00000265056.7	+	16	2945	c.2701C>T	c.(2701-2703)Ctg>Ttg	p.L901L	MCM2_ENST00000468414.1_3'UTR	NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	901					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GAAAATGATCCTGCAGCAGTT	0.493000													18	49					0	0	1	0	0
CRP	1401	broad.mit.edu	37	1	159683778	159683778	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159683778G>A	ENST00000255030.5	-	2	315	c.212C>T	c.(211-213)tCg>tTg	p.S71L	CRP_ENST00000368111.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368112.1_Intron|CRP_ENST00000368110.1_Intron|CRP_ENST00000437342.1_Intron	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	71	Pentaxin.			YSIFSYATKRQDNEIL -> TVFSRMPPRDKTMRFF (in Ref. 4; CAA39671).	acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	GGTGGCATACGAGAAAATACT	0.448000													27	72					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94145923	94145923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94145923G>A	ENST00000282020.4	+	7	1380	c.1122G>A	c.(1120-1122)aaG>aaA	p.K374K	GRID2_ENST00000510992.1_Silent_p.K279K	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	374					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGACCATCAAGAAGGTAACTT	0.383000													16	41					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423271	56423271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56423271G>A	ENST00000588751.1	-	5	1936	c.1912C>T	c.(1912-1914)Ctt>Ttt	p.L638F	NLRP13_ENST00000342929.3_Missense_Mutation_p.L638F			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	638							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAGTGAAAAAGTCGTAGAATG	0.418000													32	81					0	0	1	0	0
FTMT	94033	broad.mit.edu	37	5	121188184	121188184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:121188184G>A	ENST00000321339.1	+	1	535	c.526G>A	c.(526-528)Gaa>Aaa	p.E176K		NM_177478.1	NP_803431.1	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial	176	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	33		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GTCGTTGCTGGAATTGCACGC	0.507000													19	151					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	132110631	132110631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:132110631G>A	ENST00000404460.1	+	7	516	c.462G>A	c.(460-462)acG>acA	p.T154T	PLEKHB2_ENST00000303908.3_Silent_p.T154T			Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	0						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		ACACCACCACGAGTGCAAAAA	0.453000													9	41					0	0	1	0	0
BLVRA	644	broad.mit.edu	37	7	43846778	43846778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43846778C>T	ENST00000402924.1	+	9	998	c.835C>T	c.(835-837)Ctg>Ttg	p.L279L	BLVRA_ENST00000265523.4_Silent_p.L279L	NM_001253823.1	NP_001240752.1	P53004	BIEA_HUMAN	biliverdin reductase A	279					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			endometrium(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(2)	12					NADH(DB00157)	GAAACGCATCCTGCACTGCCT	0.433000													32	75					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321663	52321663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:52321663G>A	ENST00000356297.4	-	17	2621	c.2521C>T	c.(2521-2523)Cct>Tct	p.P841S	PXDNL_ENST00000543296.1_Missense_Mutation_p.P841S	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	841					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GGGAAACAAGGAGGGTCGTTG	0.692000													9	27					0	0	1	0	0
TNFRSF18	8784	broad.mit.edu	37	1	1139810	1139810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1139810C>T	ENST00000379268.2	-	3	486	c.367G>A	c.(367-369)Ggc>Agc	p.G123S	TNFRSF18_ENST00000379265.5_Missense_Mutation_p.G123S|TNFRSF18_ENST00000486728.1_Missense_Mutation_p.G51S|TNFRSF18_ENST00000328596.6_Missense_Mutation_p.G123S	NM_004195.2|NM_148902.1	NP_004186.1|NP_683700.1	Q9Y5U5	TNR18_HUMAN	tumor necrosis factor receptor superfamily, member 18	123					anti-apoptosis|apoptosis	extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCTTCGTGGCCCCCGGAGAAG	0.652000													18	35					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44102413	44102413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:44102413C>T	ENST00000272286.2	+	11	1707	c.1617C>T	c.(1615-1617)gtC>gtT	p.V539V		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	539	ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GGCTGGTGGTCTTCTGTTGCA	0.612000													13	95					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27218585	27218585	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:27218585G>A	ENST00000230582.3	+	5	606	c.591_splice	c.e5+1	p.K197_splice	PRSS16_ENST00000421826.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	197					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CCCGGCTGAAGGTCCTGCGAC	0.652000													15	43					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575102	136575102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136575102C>T	ENST00000264162.2	-	6	1526	c.1516G>A	c.(1516-1518)Gat>Aat	p.D506N		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	506	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCACCATGATCCTGCAGGGCC	0.587000													23	44					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89671018	89671018	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:89671018C>T	ENST00000264344.5	-	16	2190	c.1983G>A	c.(1981-1983)gaG>gaA	p.E661E	FAM13A_ENST00000503556.1_Silent_p.E321E|FAM13A_ENST00000513837.1_Silent_p.E307E|FAM13A_ENST00000511976.1_Silent_p.E247E|FAM13A_ENST00000508369.1_Silent_p.E335E|FAM13A_ENST00000395002.2_Silent_p.E335E	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	661					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						GTGTCAGGTCCTCTTGCTCAT	0.502000													23	55					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	100200274	100200274	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100200274G>A	ENST00000547776.2	-	4	576	c.577C>T	c.(577-579)Cgc>Tgc	p.R193C	ANKS1B_ENST00000547010.1_Intron|ANKS1B_ENST00000329257.7_Missense_Mutation_p.R193C	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	193						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GTGTGCTTGCGAGTGTTGCAG	0.527000													16	59					0	0	1	0	0
NDN	4692	broad.mit.edu	37	15	23931438	23931438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23931438G>A	ENST00000331837.4	-	1	1012	c.927C>T	c.(925-927)ccC>ccT	p.P309P		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	309					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		AGTGGGCAGTGGGATTAGCCT	0.597000									Prader-Willi syndrome				23	56					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52472066	52472066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52472066G>A	ENST00000231721.2	-	14	1658	c.1659C>T	c.(1657-1659)agC>agT	p.S553S		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	553					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GCTTGCCAAGGCTGGGGCGGT	0.667000													9	32					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104999239	104999239	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:104999239C>T	ENST00000372582.1	+	10	2017	c.1261C>T	c.(1261-1263)Cct>Tct	p.P421S	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.P421S|IL1RAPL2_ENST00000485671.1_3'UTR|IL1RAPL2_ENST00000538500.1_Missense_Mutation_p.P26S	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	421	TIR.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						CTGTGACAATCCTGAAGAAGA	0.388000													47	38					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188055	140188055	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140188055G>A	ENST00000530339.1	+	1	1283	c.1283G>A	c.(1282-1284)cGa>cAa	p.R428Q	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.R428Q|PCDHA4_ENST00000512229.2_Missense_Mutation_p.R428Q|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGACCGCGCGAGACGGGGGC	0.617000													45	154					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94841843	94841843	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94841843G>A	ENST00000357742.4	+	1	349	c.349G>A	c.(349-351)Gaa>Aaa	p.E117K	MCTP2_ENST00000543482.1_Missense_Mutation_p.E117K|MCTP2_ENST00000451018.3_Missense_Mutation_p.E117K|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	117					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			CCATGTGGTGGAAACAGACTC	0.532000													36	203					0	0	1	0	0
CLEC3A	10143	broad.mit.edu	37	16	78062033	78062033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:78062033G>A	ENST00000299642.4	+	2	257	c.172G>A	c.(172-174)Gaa>Aaa	p.E58K	CLEC3A_ENST00000575655.1_Missense_Mutation_p.E49K|RP11-281J9.2_ENST00000563114.1_RNA	NM_001244755.1	NP_001231684.1	O75596	CLC3A_HUMAN	C-type lectin domain family 3, member A	49					skeletal system development	extracellular region	sugar binding			NS(1)|endometrium(2)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	18						GACTCAAATTGAAAAGCTCTG	0.443000													33	54					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124351406	124351406	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124351406G>A	ENST00000360013.3	+	35	5443	c.5316G>A	c.(5314-5316)acG>acA	p.T1772T	KALRN_ENST00000428018.2_Silent_p.T75T|KALRN_ENST00000291478.4_Silent_p.T75T|KALRN_ENST00000393496.1_Silent_p.T145T	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1772					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGTGGCTGACGAGTCCTGTGC	0.577000													18	87					0	0	1	0	0
HCAR1	27198	broad.mit.edu	37	12	123214634	123214634	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123214634C>T	ENST00000432564.1	-	1	495	c.253G>A	c.(253-255)Gac>Aac	p.D85N	HCAR1_ENST00000356987.2_Missense_Mutation_p.D85N|HCAR1_ENST00000436083.2_Missense_Mutation_p.D85N	NM_032554.3	NP_115943.1	Q9BXC0	HCAR1_HUMAN	hydroxycarboxylic acid receptor 1	85					response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)	10						CAGGGAATGTCCCCAAAAGCC	0.527000													14	28					0	0	1	0	0
HAPLN3	145864	broad.mit.edu	37	15	89424951	89424951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89424951G>A	ENST00000359595.3	-	3	344	c.130C>T	c.(130-132)Ctt>Ttt	p.L44F	HAPLN3_ENST00000562889.1_Missense_Mutation_p.L106F	NM_178232.2	NP_839946.1	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	44					cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	17	Lung NSC(78;0.0392)|all_lung(78;0.077)					ACTCCATTAAGGAGGTCTTGG	0.622000													26	74					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6867615	6867615	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6867615G>A	ENST00000299454.4	+	1	733	c.702G>A	c.(700-702)ggG>ggA	p.G234G	OR10A5_ENST00000379831.2_Silent_p.G238G			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAGCTAAAGGGAAGCATAAAG	0.453000													69	188					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984115	85984115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85984115G>A	ENST00000372113.4	-	2	871	c.866C>T	c.(865-867)cCc>cTc	p.P289L	LRIT2_ENST00000538192.1_Missense_Mutation_p.P289L	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	289	Ig-like.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						CATACTCAGGGGATAAGTCCA	0.527000													19	40					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241812411	241812411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241812411C>T	ENST00000307503.3	+	5	927	c.540C>T	c.(538-540)ctC>ctT	p.L180L		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	180					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AGTGCCTGCTCCTGGTGGATT	0.657000													29	124					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655181	19655181	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19655181C>T	ENST00000586018.1	+	8	1947	c.1845C>T	c.(1843-1845)ttC>ttT	p.F615F	CILP2_ENST00000291495.4_Silent_p.F609F			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	609						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GGGTGACGTTCGTGGACCCCC	0.692000													53	111					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47403772	47403772	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47403772C>T	ENST00000310638.4	-	2	264	c.233G>A	c.(232-234)tGg>tAg	p.W78*	CYP4A11_ENST00000371904.4_Nonsense_Mutation_p.W78*|CYP4A11_ENST00000457840.2_5'UTR|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371905.1_Nonsense_Mutation_p.W78*	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	78					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	TGTCTCCACCCATTTCTGAAT	0.483000													32	94					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35774065	35774065	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35774065G>A	ENST00000440995.2	+	28	4005	c.4005G>A	c.(4003-4005)agG>agA	p.R1335R	SPEF2_ENST00000356031.3_Silent_p.R1340R|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1340					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAATCAAAAGGAAAAATGAAC	0.388000													9	68					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38743485	38743485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38743485C>T	ENST00000449082.2	-	26	4501	c.4502G>A	c.(4501-4503)aGt>aAt	p.S1501N		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1501					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTTTTCTTCACTTTGGTCATC	0.448000													30	70					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114305109	114305109	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114305109G>A	ENST00000309235.5	+	6	2052	c.1894G>A	c.(1894-1896)Gaa>Aaa	p.E632K	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	632					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						TCATTCAGGAGAAAAACCCTA	0.373000													13	58					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56247040	56247040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56247040G>A	ENST00000361673.3	-	4	1181	c.968C>T	c.(967-969)tCa>tTa	p.S323L		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	323							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GTCATCATCTGAAAACTCCTC	0.458000											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	204					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36552954	36552954	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:36552954C>T	ENST00000258749.5	-	21	2031	c.1632G>A	c.(1630-1632)tgG>tgA	p.W544*	AOAH_ENST00000431169.1_Missense_Mutation_p.G584E|AOAH_ENST00000535891.1_Nonsense_Mutation_p.W512*|AOAH_ENST00000538464.1_Nonsense_Mutation_p.W266*	NM_001637.3	NP_001628.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	544					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GCACCTTTTTCCAGAAATGAT	0.498000													26	61					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17690098	17690098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17690098G>A	ENST00000375448.4	+	16	1866	c.1840G>A	c.(1840-1842)Gag>Aag	p.E614K		NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	614					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CTGCCTGGAGGAGAAGGTGTG	0.617000													11	24					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132016264	132016264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:132016264C>T	ENST00000374786.1	+	2	735	c.256C>T	c.(256-258)Cct>Tct	p.P86S	NTM_ENST00000374791.3_Missense_Mutation_p.P86S|NTM_ENST00000539799.1_Missense_Mutation_p.P86S|NTM_ENST00000427481.2_Missense_Mutation_p.P77S|NTM_ENST00000374784.1_Missense_Mutation_p.P86S|NTM_ENST00000425719.2_Missense_Mutation_p.P86S	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	86	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						GTGCCTGGATCCTCGCGTGGT	0.572000													21	57					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157648592	157648592	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157648592C>T	ENST00000368184.3	-	15	2404	c.2113G>A	c.(2113-2115)Ggg>Agg	p.G705R	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Missense_Mutation_p.G705R	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	705						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CTAGCCTCCCCTGCAGAGTCG	0.468000													18	46					0	0	1	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87151852	87151852	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87151852G>A	ENST00000285393.3	+	3	611	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K	CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	157					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						CATTCTGATCGAAACGCCATT	0.418000													30	74					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201046127	201046127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201046127C>T	ENST00000362061.3	-	12	1974	c.1748G>A	c.(1747-1749)gGg>gAg	p.G583E	CACNA1S_ENST00000367338.3_Missense_Mutation_p.G583E	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	583					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GTCATACCTCCCCCCAAAGAG	0.572000													35	100					0	0	1	0	0
TMEM5	10329	broad.mit.edu	37	12	64173857	64173857	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:64173857C>T	ENST00000261234.6	+	1	275	c.117C>T	c.(115-117)tcC>tcT	p.S39S	RP11-415I12.3_ENST00000509615.2_RNA	NM_014254.1	NP_055069.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	39						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		cggccgggtccccgcggggcc	0.721000													6	12					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180338371	180338371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180338371G>A	ENST00000231229.4	+	3	664	c.430G>A	c.(430-432)Gga>Aga	p.G144R	BTNL8_ENST00000533815.2_5'UTR|BTNL8_ENST00000400707.3_Missense_Mutation_p.G19R|BTNL8_ENST00000511704.1_Missense_Mutation_p.G28R|BTNL8_ENST00000340184.4_Missense_Mutation_p.G144R|BTNL8_ENST00000508408.1_Missense_Mutation_p.G144R|BTNL8_ENST00000505126.1_5'UTR	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	144	Ig-like V-type 2.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCATCACGGGATATGTTGA	0.527000													38	404					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19206959	19206959	+	Missense_Mutation	SNP	C	C	T	rs117940121	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19206959C>T	ENST00000318596.7	+	2	177	c.26C>T	c.(25-27)cCg>cTg	p.P9L		NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	9					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			AAGGAAGGCCCGGTGCGATTG	0.612000													8	30					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222818993	222818993	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:222818993C>T	ENST00000344922.5	+	7	3600	c.3575C>T	c.(3574-3576)tCg>tTg	p.S1192L	MIA3_ENST00000344507.1_Intron|MIA3_ENST00000344441.6_Missense_Mutation_p.S1192L|MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000340535.7_Missense_Mutation_p.S70L	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1192					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		GGAATTGCTTCGTTTGCCATT	0.383000													17	46					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112989677	112989677	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112989677C>T	ENST00000495514.1	+	6	1257	c.553C>T	c.(553-555)Ctc>Ttc	p.L185F	BOC_ENST00000355385.3_Missense_Mutation_p.L185F|BOC_ENST00000273395.4_Missense_Mutation_p.L185F			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	185	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			CTCAGGGAACCTCCAGATTGT	0.562000													27	85					0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55179342	55179342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55179342C>T	ENST00000391736.1	+	14	1534	c.1219C>T	c.(1219-1221)Ccc>Tcc	p.P407S	LILRB4_ENST00000270452.2_Missense_Mutation_p.P407S|LILRB4_ENST00000430952.2_Missense_Mutation_p.P406S|LILRB4_ENST00000391733.3_Missense_Mutation_p.P408S|LILRB4_ENST00000391734.3_Missense_Mutation_p.P354S	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	407						integral to membrane|plasma membrane	antigen binding|receptor activity	p.P407S(1)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		ATCTGAAGCCCCCCAGGATGT	0.647000													27	102					0	0	1	0	0
C11orf35	256329	broad.mit.edu	37	11	556039	556039	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:556039G>A	ENST00000329451.3	-	11	1396	c.1334C>T	c.(1333-1335)tCc>tTc	p.S445F		NM_173573.2	NP_775844.2	Q8IXW0	CK035_HUMAN	chromosome 11 open reading frame 35	445										NS(1)|breast(1)|central_nervous_system(1)|lung(4)|pancreas(1)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCGCGGATGGAGAGGAGGGG	0.776000													8	17					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233515037	233515037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233515037G>A	ENST00000366624.3	+	9	2546	c.2285G>A	c.(2284-2286)gGa>gAa	p.G762E	MLK4_ENST00000366622.1_Missense_Mutation_p.G208E	NM_032435.2	NP_115811.2																					AAACGAGAGGGAATCTTCCAG	0.602000													21	81					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83818732	83818732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:83818732C>T	ENST00000349129.2	+	5	684	c.424C>T	c.(424-426)Cct>Tct	p.P142S	DOPEY1_ENST00000369739.3_Missense_Mutation_p.P142S|DOPEY1_ENST00000237163.5_Missense_Mutation_p.P142S|DOPEY1_ENST00000536812.1_Missense_Mutation_p.P142S	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	142					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AACACTGAAACCTGGTCTACA	0.388000													35	56					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52322009	52322009	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:52322009C>T	ENST00000356297.4	-	17	2275	c.2175G>A	c.(2173-2175)gcG>gcA	p.A725A	PXDNL_ENST00000543296.1_Silent_p.A725A	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	725					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CGCGGTACTTCGCATGGAAAC	0.657000													7	40					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149508805	149508805	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149508805G>A	ENST00000378016.2	+	0	9544							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTGTGCGGAGGGTAAGGAAGC	0.632000													16	123					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17052326	17052326	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:17052326C>T	ENST00000418129.2	+	2	1575	c.1110C>T	c.(1108-1110)ttC>ttT	p.F370F	PLCL2_ENST00000396755.2_Silent_p.F370F|PLCL2_ENST00000460467.1_Intron|PLCL2_ENST00000432376.1_Silent_p.F370F	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	496					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						AGATAGTTTTCCGCAGTGTCA	0.398000													31	63					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119953055	119953055	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119953055C>T	ENST00000307142.4	+	4	3321	c.3125C>T	c.(3124-3126)tCa>tTa	p.S1042L	SYNPO2_ENST00000434046.2_Missense_Mutation_p.S1042L|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000429713.2_Missense_Mutation_p.S1042L	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	1042						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GAGGCCTCCTCACCAGTCAGT	0.542000													20	59					0	0	1	0	0
FBLN5	10516	broad.mit.edu	37	14	92353616	92353616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92353616G>A	ENST00000267620.10	-	8	952	c.783C>T	c.(781-783)acC>acT	p.T261T	FBLN5_ENST00000556154.1_Silent_p.T225T|FBLN5_ENST00000342058.4_Silent_p.T220T			Q9UBX5	FBLN5_HUMAN	fibulin 5	220	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				TGTTGACGCAGGTTTGCACGC	0.522000													49	97					0	0	1	0	0
TIPRL	261726	broad.mit.edu	37	1	168153170	168153170	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168153170C>T	ENST00000367833.2	+	2	280	c.135C>T	c.(133-135)ctC>ctT	p.L45L	TIPRL_ENST00000367830.3_Silent_p.L45L	NM_152902.3	NP_690866.1	O75663	TIPRL_HUMAN	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	45					DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			breast(1)|kidney(1)|large_intestine(1)|ovary(2)|skin(1)	6	all_hematologic(923;0.215)					TGCCATCTCTCCCTGAAATGA	0.388000													40	98					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196671484	196671484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196671484G>A	ENST00000312428.6	-	54	10256	c.10156C>T	c.(10156-10158)Cgt>Tgt	p.R3386C		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3386			R -> H (in dbSNP:rs6708527).		ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTCAAGCAACGAATAATAAGC	0.393000													12	46					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107848059	107848059	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107848059G>A	ENST00000379028.3	-	13	1590	c.1120C>T	c.(1120-1122)Cca>Tca	p.P374S	NRCAM_ENST00000413765.2_Missense_Mutation_p.P355S|NRCAM_ENST00000379022.4_Missense_Mutation_p.P374S|NRCAM_ENST00000379024.4_Missense_Mutation_p.P355S|NRCAM_ENST00000425651.2_Missense_Mutation_p.P374S|NRCAM_ENST00000351718.4_Missense_Mutation_p.P368S			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	374	Ig-like 4.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						TCCTCTCCTGGGGACAGCACA	0.438000													4	53					0	0	1	0	0
MFSD6L	162387	broad.mit.edu	37	17	8700810	8700810	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8700810C>T	ENST00000329805.4	-	1	1857	c.1629G>A	c.(1627-1629)cgG>cgA	p.R543R		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	543						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						GGGGCAGCCTCCGCTGTATGG	0.602000													31	22					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37447489	37447489	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:37447489G>A	ENST00000374660.1	+	15	1806	c.1707G>A	c.(1705-1707)ttG>ttA	p.L569L	ANKRD30A_ENST00000602533.1_Silent_p.L569L|ANKRD30A_ENST00000361713.1_Silent_p.L569L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	625						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CCTTAGAATTGAAGGACATGC	0.289000													30	97					0	0	1	0	0
CLDN1	9076	broad.mit.edu	37	3	190039813	190039813	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:190039813C>T	ENST00000295522.3	-	1	451	c.183G>A	c.(181-183)caG>caA	p.Q61Q		NM_021101.4	NP_066924.1	O95832	CLD1_HUMAN	claudin 1	61					calcium-independent cell-cell adhesion|interspecies interaction between organisms	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity			lung(9)	9	all_cancers(143;2.95e-10)|Ovarian(172;0.0512)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.015)		TGCACTGGATCTGCCCGGTGC	0.622000													6	89					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44975656	44975656	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:44975656C>T	ENST00000340446.4	-	1	826	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	179						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		AGGGCATCTTCCTTTGACTTT	0.398000													73	186					0	0	1	0	0
CPNE3	8895	broad.mit.edu	37	8	87557009	87557009	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87557009C>T	ENST00000521271.1	+	9	837	c.675C>T	c.(673-675)ctC>ctT	p.L225L	CPNE3_ENST00000198765.4_Silent_p.L225L	NM_003909.3	NP_003900.1	O75131	CPNE3_HUMAN	copine III	225	C2 2.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	23						CACATGATCTCATTGGAACAT	0.308000													48	104					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19746291	19746291	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19746291C>T	ENST00000203556.4	-	15	1630	c.1493G>A	c.(1492-1494)cGa>cAa	p.R498Q	GMIP_ENST00000445806.2_Missense_Mutation_p.R469Q|GMIP_ENST00000587238.1_Missense_Mutation_p.R472Q|GMIP_ENST00000586269.1_5'UTR	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	498					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GCCCCGCAGTCGCCGCAGCTG	0.647000													20	58					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997556	115997556	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:115997556C>T	ENST00000264363.2	-	2	1315	c.637G>A	c.(637-639)Ggc>Agc	p.G213S		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	213	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGAAGAGGGCCTTTCTCAACC	0.408000													34	100					0	0	1	0	0
CXXC5	51523	broad.mit.edu	37	5	139060312	139060312	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139060312C>T	ENST00000302517.3	+	2	918	c.204C>T	c.(202-204)ccC>ccT	p.P68P	CXXC5_ENST00000511048.1_Silent_p.P68P	NM_016463.7	NP_057547.5	Q7LFL8	CXXC5_HUMAN	CXXC finger protein 5	68					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|nucleus	DNA binding|signal transducer activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGTGAGCCCCTCAACAAGA	0.632000													29	96					0	0	1	0	0
GALNT7	51809	broad.mit.edu	37	4	174169415	174169415	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:174169415C>T	ENST00000265000.4	+	2	494	c.411C>T	c.(409-411)ccC>ccT	p.P137P	GALNT7_ENST00000512285.1_Silent_p.P137P	NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	137					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		ACTTTGAACCCAAAGAACCTG	0.483000													34	95					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21795948	21795948	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21795948G>A	ENST00000206660.6	+	17	2877	c.2877G>A	c.(2875-2877)aaG>aaA	p.K959K	RPGRIP1_ENST00000556336.1_Silent_p.K616K|RPGRIP1_ENST00000382933.4_Silent_p.K285K|RPGRIP1_ENST00000400017.2_Silent_p.K959K|RPGRIP1_ENST00000557771.1_Silent_p.K921K|RPGRIP1_ENST00000307974.4_Silent_p.K318K			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	959	Interaction with RPGR.				response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		AAGAGGAAAAGGCTTCATTTC	0.463000													4	26					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35473605	35473605	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35473605C>T	ENST00000229771.6	-	11	1104	c.1025G>A	c.(1024-1026)cGa>cAa	p.R342Q	TULP1_ENST00000322263.4_Missense_Mutation_p.R289Q	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	342					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						GCTCCGTTTTCGTTTCCTGCC	0.567000													27	52					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269936	150269936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150269936G>A	ENST00000255945.2	+	3	953	c.778G>A	c.(778-780)Gaa>Aaa	p.E260K	GIMAP4_ENST00000461940.1_Missense_Mutation_p.E274K|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	260							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGAGGAGTATGAAGAGAAAAT	0.468000													6	45					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36223190	36223190	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36223190C>T	ENST00000222270.7	+	28	5740	c.5740C>T	c.(5740-5742)Cgt>Tgt	p.R1914C	WBP7_ENST00000420124.1_Missense_Mutation_p.R1914C|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					CAGACGTTCCCGTCGTCCCAG	0.642000													7	13					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10647978	10647978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10647978G>A	ENST00000547195.1	-	8	1130	c.630C>T	c.(628-630)acC>acT	p.T210T	MRVI1_ENST00000531107.1_Silent_p.T293T|MRVI1_ENST00000552103.1_Silent_p.T210T|MRVI1_ENST00000421747.1_Silent_p.T292T|MRVI1_ENST00000558540.1_5'UTR|MRVI1_ENST00000527509.2_Silent_p.T210T|MRVI1_ENST00000545852.1_5'UTR|MRVI1_ENST00000436272.1_Silent_p.T274T|MRVI1_ENST00000541483.1_Intron|MRVI1_ENST00000423302.2_Silent_p.T301T|MRVI1_ENST00000424001.1_5'UTR|MRVI1_ENST00000534266.2_5'UTR	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	274					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTTTGGGTGTGGTCTCGGGGT	0.567000													5	25					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158607836	158607836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158607836C>T	ENST00000368148.3	-	36	5356	c.5176G>A	c.(5176-5178)Gaa>Aaa	p.E1726K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1726K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1726					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					ATCCAGGATTCCTCATCATCT	0.418000													10	150					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43898243	43898243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43898243C>T	ENST00000562955.1	+	37	5327	c.5327C>T	c.(5326-5328)cCc>cTc	p.P1776L	SZT2_ENST00000372442.1_Missense_Mutation_p.P934L	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1833						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GAGGGTGTCCCCCTCATCAGC	0.607000													60	130					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220791985	220791985	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:220791985G>A	ENST00000402574.1	+	9	1394	c.392G>A	c.(391-393)cGa>cAa	p.R131Q	MARK1_ENST00000366917.4_Missense_Mutation_p.R266Q|MARK1_ENST00000366918.4_Missense_Mutation_p.R244Q	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	266	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		AAGGAACTGCGAGAGCGAGTT	0.338000													33	100					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052376	44052376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:44052376G>A	ENST00000306006.6	-	2	1804	c.1152C>T	c.(1150-1152)ttC>ttT	p.F384F	ZNF239_ENST00000535642.1_Silent_p.F384F|ZNF239_ENST00000374446.2_Silent_p.F384F|ZNF239_ENST00000426961.1_Silent_p.F384F	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						AGCTCTGGCTGAAACCCTTCC	0.527000													24	68					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124258721	124258721	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124258721G>A	ENST00000409039.3	+	5	373	c.348G>A	c.(346-348)atG>atA	p.M116I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	116	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTACCGACATGAAGGAAGCTA	0.403000													20	84					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30371579	30371579	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30371579C>A	ENST00000340513.4	+	13	1904	c.1376C>A	c.(1375-1377)cCt>cAt	p.P459H	TPX2_ENST00000300403.6_Missense_Mutation_p.P423H			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	423					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			AAGAAACCACCTGTGAAACCA	0.408000													41	106					7.63091e-17	7.67435e-17	1	1	0
PCDHGB3	56102	broad.mit.edu	37	5	140751918	140751918	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140751918C>T	ENST00000576222.1	+	1	2088	c.1957C>T	c.(1957-1959)Cct>Tct	p.P653S	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGACAGCAGCCTCTTTCAGC	0.647000													25	64					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688486	26688486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26688486C>T	ENST00000529632.2	+	2	405	c.209C>T	c.(208-210)cCc>cTc	p.P70L	SEZ6L_ENST00000343706.4_Missense_Mutation_p.P70L|SEZ6L_ENST00000360929.3_Missense_Mutation_p.P70L|SEZ6L_ENST00000404234.3_Missense_Mutation_p.P70L|SEZ6L_ENST00000248933.6_Missense_Mutation_p.P70L|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000403121.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	70						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GTAACAGCGCCCCCCAGTTCC	0.632000													8	42					0	0	1	0	0
IGJ	3512	broad.mit.edu	37	4	71532205	71532205	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71532205C>T	ENST00000254801.4	-	1	172	c.3G>A	c.(1-3)atG>atA	p.M1I	IGJ_ENST00000543780.1_Start_Codon_SNP_p.M1I|ENAM_ENST00000472903.1_Intron	NM_144646.3	NP_653247.1	P01591	IGJ_HUMAN	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	1					immune response	extracellular region	antigen binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7			Lung(101;0.235)			AATGGTTCTTCATCTTGACTT	0.388000													25	47					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39796071	39796071	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:39796071C>T	ENST00000553728.1	+	24	3494	c.3281C>T	c.(3280-3282)tCa>tTa	p.S1094L	CTAGE5_ENST00000557038.1_Missense_Mutation_p.S479L|CTAGE5_ENST00000280083.3_Missense_Mutation_p.S559L|CTAGE5_ENST00000341502.5_Missense_Mutation_p.S559L|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.S530L|CTAGE5_ENST00000341749.3_Missense_Mutation_p.S547L|CTAGE5_ENST00000556148.1_Missense_Mutation_p.S484L|CTAGE5_ENST00000553352.1_Missense_Mutation_p.S530L|CTAGE5_ENST00000348007.3_Missense_Mutation_p.S516L|CTAGE5_ENST00000396165.4_Missense_Mutation_p.S530L|CTAGE5_ENST00000396158.2_Missense_Mutation_p.S564L																							TAATTAGGCTCACGAGGCCCA	0.358000													21	93					0	0	1	0	0
ACER1	125981	broad.mit.edu	37	19	6309787	6309787	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6309787G>A	ENST00000301452.4	-	4	486	c.409C>T	c.(409-411)Ctg>Ttg	p.L137L		NM_133492.2	NP_597999.1	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	137						endoplasmic reticulum membrane|integral to membrane	ceramidase activity			NS(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)	15						GTGGGCCGCAGGAAGGACAGA	0.607000													13	63					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51853778	51853778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51853778C>T	ENST00000453097.2	+	8	1116	c.899C>T	c.(898-900)gCc>gTc	p.A300V	SLC4A8_ENST00000394856.1_Missense_Mutation_p.A247V|SLC4A8_ENST00000514353.3_Missense_Mutation_p.A247V|SLC4A8_ENST00000358657.3_Missense_Mutation_p.A327V|SLC4A8_ENST00000535225.2_Missense_Mutation_p.A247V	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	300					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		GGGGCCGAGGCCTCCAATGTC	0.463000													24	210					0	0	1	0	0
STARD3NL	83930	broad.mit.edu	37	7	38247193	38247193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38247193C>T	ENST00000009041.7	+	2	345	c.88C>T	c.(88-90)Ccc>Tcc	p.P30S	STARD3NL_ENST00000544203.1_Missense_Mutation_p.P23S|STARD3NL_ENST00000434197.1_Missense_Mutation_p.P30S|STARD3NL_ENST00000396013.1_Missense_Mutation_p.P30S	NM_032016.3	NP_114405.1	O95772	MENTO_HUMAN	STARD3 N-terminal like	30						integral to membrane|late endosome membrane				endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10						TTCCATCAACCCCACACAACT	0.507000													30	87					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21542995	21542995	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21542995C>T	ENST00000298694.4	+	3	1233	c.1106C>T	c.(1105-1107)cCt>cTt	p.P369L	ARHGEF40_ENST00000298693.3_Missense_Mutation_p.P369L			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	369	Gly-rich.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						GAAGGACCACCTGGTACCCCT	0.642000													10	51					0	0	1	0	0
GJA1	2697	broad.mit.edu	37	6	121768414	121768414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:121768414G>A	ENST00000282561.3	+	2	578	c.421G>A	c.(421-423)Gag>Aag	p.E141K		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	141					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CGGTATTGAAGAGCATGGTAA	0.453000													40	46					0	0	1	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869096	22869096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22869096C>T	ENST00000302097.3	-	2	1111	c.859G>A	c.(859-861)Gat>Aat	p.D287N		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	287					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GGCTGCCCATCTCCTTTATGC	0.383000													18	191					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350522	30350522	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30350522G>A	ENST00000359358.4	-	2	471	c.33C>T	c.(31-33)ttC>ttT	p.F11F	KLHL14_ENST00000358095.4_Silent_p.F11F|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	11						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GGCTGGGGTCGAAGGTGGAGG	0.642000													16	62					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119727714	119727714	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:119727714G>A	ENST00000327097.4	+	3	359	c.224G>A	c.(223-225)cGg>cAg	p.R75Q	MARCO_ENST00000541757.1_5'UTR	NM_006770.3	NP_006761.1	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	75					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						GCGCGGCTCCGGGTCCTGGAG	0.562000													19	75					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71209547	71209547	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71209547G>A	ENST00000393567.2	-	5	629	c.479C>T	c.(478-480)tCc>tTc	p.S160F	HYDIN_ENST00000321489.5_Missense_Mutation_p.S160F|HYDIN_ENST00000541601.1_Missense_Mutation_p.S177F|HYDIN_ENST00000448691.1_Missense_Mutation_p.S160F|HYDIN_ENST00000288168.10_Missense_Mutation_p.S177F|HYDIN_ENST00000393550.2_Missense_Mutation_p.S160F|HYDIN_ENST00000538248.1_Missense_Mutation_p.S187F|HYDIN_ENST00000448089.2_Missense_Mutation_p.S160F	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	160										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TCGGAATATGGAAGGCACTCC	0.433000													20	94					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202446936	202446936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202446936G>A	ENST00000439140.1	-	5	565	c.521C>T	c.(520-522)cCc>cTc	p.P174L	ALS2CR11_ENST00000450242.1_Missense_Mutation_p.P174L|ALS2CR11_ENST00000439802.1_Missense_Mutation_p.P174L|ALS2CR11_ENST00000286195.3_Missense_Mutation_p.P174L	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	174										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						ATAACGTCTGGGAACCTCAAT	0.289000													24	78					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31864577	31864577	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31864577G>A	ENST00000396184.3	-	14	1514	c.1310C>T	c.(1309-1311)cCc>cTc	p.P437L	PDE1C_ENST00000396182.2_Missense_Mutation_p.P437L|PDE1C_ENST00000396191.1_Missense_Mutation_p.P437L|PDE1C_ENST00000321453.7_Missense_Mutation_p.P437L|PDE1C_ENST00000396193.1_Missense_Mutation_p.P497L	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	437	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			AGTGAAGGTGGGTTCCACGAT	0.458000													13	113					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123484269	123484269	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123484269C>T	ENST00000529750.1	+	15	2028	c.1701C>T	c.(1699-1701)ccC>ccT	p.P567P	GRAMD1B_ENST00000456860.2_Silent_p.P574P|GRAMD1B_ENST00000322282.7_Silent_p.P567P|GRAMD1B_ENST00000450171.2_Silent_p.P258P	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	567						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		GGAAGCGTCCCCATGCCCACC	0.577000													16	33					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143563058	143563058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143563058C>T	ENST00000517894.1	+	11	3010	c.2116C>T	c.(2116-2118)Cct>Tct	p.P706S	BAI1_ENST00000323289.5_Missense_Mutation_p.P706S			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	706					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CAGCCCCACCCCTGGGGACGT	0.607000													4	14					0	0	1	0	0
CD247	919	broad.mit.edu	37	1	167407814	167407814	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167407814C>T	ENST00000392122.3	-	4	437	c.293G>A	c.(292-294)gGa>gAa	p.G98E	CD247_ENST00000362089.5_Missense_Mutation_p.G98E|CD247_ENST00000483825.1_5'UTR	NM_000734.3|NM_198053.2	NP_000725.1|NP_932170.1	P20963	CD3Z_HUMAN	CD247 molecule	98					interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(543;0.236)			TACCGGCTTTCCCCCCATCTC	0.562000													52	89					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021806	5021806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5021806G>A	ENST00000382545.3	+	2	2369	c.1262G>A	c.(1261-1263)gGg>gAg	p.G421E	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	421					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAAACTGAGGGGGAAGAGCAG	0.527000													103	240					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3224759	3224759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3224759C>T	ENST00000520002.1	-	21	3468	c.2913G>A	c.(2911-2913)atG>atA	p.M971I	CSMD1_ENST00000542608.1_Missense_Mutation_p.M970I|CSMD1_ENST00000539096.1_Missense_Mutation_p.M970I|CSMD1_ENST00000537824.1_Missense_Mutation_p.M970I|CSMD1_ENST00000602723.1_Missense_Mutation_p.M971I|CSMD1_ENST00000400186.3_Missense_Mutation_p.M971I|CSMD1_ENST00000602557.1_Missense_Mutation_p.M971I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	971	CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGTGAAAGATCATTTGAACTC	0.557000													3	15					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582444	136582444	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:136582444C>T	ENST00000531224.1	-	12	2968	c.2716G>A	c.(2716-2718)Gaa>Aaa	p.E906K	BCLAF1_ENST00000392348.2_Missense_Mutation_p.E855K|BCLAF1_ENST00000530767.1_Missense_Mutation_p.E733K|BCLAF1_ENST00000031135.9_Missense_Mutation_p.E124K|BCLAF1_ENST00000527759.1_Missense_Mutation_p.E904K|BCLAF1_ENST00000527536.1_Missense_Mutation_p.E857K|BCLAF1_ENST00000353331.4_Missense_Mutation_p.E855K|BCLAF1_ENST00000529917.1_5'UTR	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	906					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCATTATTTTCCATGGTCTCT	0.378000													26	197					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117308979	117308979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:117308979C>T	ENST00000355044.3	+	26	3854	c.3728C>T	c.(3727-3729)tCc>tTc	p.S1243F	ATRNL1_ENST00000303745.7_Missense_Mutation_p.S36F|ATRNL1_ENST00000423111.2_Missense_Mutation_p.S294F	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1243						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGTTTCCTATCCTTATTGCTG	0.313000													25	69					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119288083	119288083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:119288083C>T	ENST00000338891.7	-	15	3393	c.2950G>A	c.(2950-2952)Gaa>Aaa	p.E984K	FAM184A_ENST00000352896.5_Missense_Mutation_p.E815K|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000368475.4_Missense_Mutation_p.E815K|FAM184A_ENST00000521531.1_Missense_Mutation_p.E935K	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	984										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						GGTTTTGATTCTCTCATTAGA	0.294000													16	20					0	0	1	0	0
CPB1	1360	broad.mit.edu	37	3	148545841	148545841	+	Missense_Mutation	SNP	C	C	T	rs114058679	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:148545841C>T	ENST00000491148.1	+	3	458	c.124C>T	c.(124-126)Cgc>Tgc	p.R42C	CPB1_ENST00000282957.4_Missense_Mutation_p.R42C			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	42					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TAACATAATCCGCGAGTTGGC	0.363000													27	84					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129237967	129237967	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129237967C>T	ENST00000296266.3	+	29	3754	c.3562C>T	c.(3562-3564)Cta>Tta	p.L1188L	IFT122_ENST00000504021.1_Silent_p.L1014L|IFT122_ENST00000431818.2_Silent_p.L987L|IFT122_ENST00000349441.2_Silent_p.L1027L|IFT122_ENST00000507564.1_Silent_p.L1130L|IFT122_ENST00000347300.2_Silent_p.L1078L|IFT122_ENST00000440957.2_Silent_p.L928L|IFT122_ENST00000348417.2_Silent_p.L1137L	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	1137					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						GATTCTGCGGCTAGTGGAGAC	0.582000													38	135					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167039933	167039933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167039933C>T	ENST00000392766.2	-	12	1295	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K	ZBBX_ENST00000307529.5_Missense_Mutation_p.E319K|ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Missense_Mutation_p.E290K|ZBBX_ENST00000392767.2_Missense_Mutation_p.E319K|ZBBX_ENST00000455345.2_Missense_Mutation_p.E319K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	319						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CATAATTTTTCCATATAGGAT	0.289000													29	68					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114290845	114290845	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:114290845G>A	ENST00000297405.5	-	3	734	c.490C>T	c.(490-492)Cat>Tat	p.H164Y	CSMD3_ENST00000352409.3_Missense_Mutation_p.H164Y|CSMD3_ENST00000343508.3_Missense_Mutation_p.H124Y|CSMD3_ENST00000455883.2_Missense_Mutation_p.H164Y	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	164	CUB 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTAAATCCATGAGCACTAACT	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	74					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115614311	115614311	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:115614311C>T	ENST00000265440.7	-	3	361		c.e3-1		TFEC_ENST00000320239.7_Intron|TFEC_ENST00000484212.1_Splice_Site|TFEC_ENST00000393485.1_Intron	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			CGTCCTCCATCTAGCAAAATA	0.323000													20	49					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048259	9048259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9048259C>T	ENST00000397910.4	-	5	33575	c.33372G>A	c.(33370-33372)gaG>gaA	p.E11124E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11126	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAGGTGTGGTCTCTGGCTCAC	0.512000													30	73					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14567016	14567016	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14567016G>A	ENST00000273083.3	-	0	250							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						ACCTGAGATAGTCAGGCCCAG	0.617000													27	59					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68208743	68208743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68208743G>A	ENST00000262215.3	-	5	951	c.562C>T	c.(562-564)Ctc>Ttc	p.L188F		NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	188					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TGATTGATGAGATTTTTGCTT	0.373000													9	101					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149509044	149509044	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149509044C>T	ENST00000378016.2	+	0	9590							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGTGTTCAGCCTCCTGTGGC	0.697000													19	39					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140433422	140433422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140433422G>A	ENST00000306549.3	+	1	2444	c.2367G>A	c.(2365-2367)atG>atA	p.M789I		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		789					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGATAAAAATGGAGGCTGGCT	0.448000													40	98					0	0	1	0	0
APOL1	8542	broad.mit.edu	37	22	36653169	36653169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36653169G>A	ENST00000319136.4	+	4	400	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	APOL1_ENST00000347595.7_Intron|APOL1_ENST00000422706.1_Missense_Mutation_p.E29K|APOL1_ENST00000426053.1_Intron|APOL1_ENST00000397279.4_Missense_Mutation_p.E29K|APOL1_ENST00000397278.3_Missense_Mutation_p.E29K|APOL1_ENST00000440669.2_Missense_Mutation_p.E29K	NM_145343.2	NP_663318.1	O14791	APOL1_HUMAN	apolipoprotein L, 1	29					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	14						GAGGGCAGAGGAAGCTGGAGC	0.502000													12	37					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141803210	141803210	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141803210C>T	ENST00000475668.2	+	70	8209	c.8155C>T	c.(8155-8157)Ccc>Tcc	p.P2719S	MGAM_ENST00000549489.2_Missense_Mutation_p.P1823S			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1823					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGTCATAACACCCTCCTTCAA	0.493000													9	22					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70986992	70986992	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70986992C>T	ENST00000354624.5	+	2	226	c.93C>T	c.(91-93)ctC>ctT	p.L31L	RP11-227H15.4_ENST00000450995.1_RNA|HKDC1_ENST00000395086.2_Silent_p.L31L	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	31					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						ACATGCGGCTCTCCGATGACA	0.617000													16	112					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140952615	140952615	+	Silent	SNP	C	C	T	rs35538393		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140952615C>T	ENST00000277549.5	+	29	4378	c.1809C>T	c.(1807-1809)ttC>ttT	p.F603F	CACNA1B_ENST00000277551.2_Silent_p.F1407F|CACNA1B_ENST00000371372.1_Silent_p.F1407F|CACNA1B_ENST00000371363.1_Silent_p.F1407F|CACNA1B_ENST00000371355.4_Silent_p.F1408F|CACNA1B_ENST00000371357.1_Silent_p.F1408F			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1407					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCTTCTTCTTCGTCAACATCT	0.537000													36	86					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31299723	31299723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:31299723C>T	ENST00000265071.2	+	5	1061	c.796C>T	c.(796-798)Ccc>Tcc	p.P266S	CDH6_ENST00000514738.1_Missense_Mutation_p.P211S	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	266	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CGACAACCCTCCCCGATTCCC	0.428000													25	81					0	0	1	0	0
TPTE2P2	644623	broad.mit.edu	37	13	52854009	52854009	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52854009C>T	ENST00000451298.1	-	0	528				RP11-64P12.8_ENST00000606031.1_RNA																							ACTGGCCTCCCGAAGATGGAA	0.303000													3	18					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107040194	107040194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107040194C>T	ENST00000409886.3	-	20	4316	c.4229G>A	c.(4228-4230)aGa>aAa	p.R1410K	RGPD3_ENST00000304514.7_Missense_Mutation_p.R1410K	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1410	RanBD1 2.				intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TGGAGTTATTCTGTGATTGGC	0.373000													113	280					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50826512	50826512	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50826512G>A	ENST00000376959.2	-	2	1861	c.1698C>T	c.(1696-1698)ccC>ccT	p.P566P	KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000477616.1_Silent_p.P566P|KCNC3_ENST00000391818.2_Intron			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	566					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CCGGTTGCGGGGGCCGGGGGA	0.657000													9	12					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48250140	48250140	+	Missense_Mutation	SNP	G	G	A	rs61739612	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48250140G>A	ENST00000394747.1	-	6	1185	c.836C>T	c.(835-837)cCc>cTc	p.P279L	ABCC11_ENST00000537808.1_Missense_Mutation_p.P279L|ABCC11_ENST00000353782.5_Missense_Mutation_p.P279L|ABCC11_ENST00000394748.1_Missense_Mutation_p.P279L|ABCC11_ENST00000356608.2_Missense_Mutation_p.P279L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	279	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CAGTACTAGGGGTCCATAGCA	0.483000													39	143					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741049	140741049	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140741049C>T	ENST00000522605.1	+	1	1347	c.1347C>T	c.(1345-1347)gcC>gcT	p.A449A	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGATAATGCCCCAGTTTTCC	0.552000													46	123					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196388524	196388524	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:196388524C>T	ENST00000328557.4	+	3	2213	c.2010C>T	c.(2008-2010)atC>atT	p.I670I		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		GCACTGTCATCGTCCTCACTT	0.597000													45	78					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96581799	96581799	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:96581799G>A	ENST00000456556.1	-	38	2462	c.2376_splice	c.e38-1	p.A793_splice	ANKRD36C_ENST00000295246.5_5'UTR|ANKRD36C_ENST00000420871.2_5'UTR|ANKRD36C_ENST00000419039.2_5'UTR					ankyrin repeat domain 36C											breast(1)|endometrium(8)|kidney(5)|lung(4)	18						ATCACTTGTAGCCTGAATGGA	0.308000													8	9					0	0	1	0	0
C1orf43	25912	broad.mit.edu	37	1	154186378	154186378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154186378G>A	ENST00000368521.5	-	4	529	c.331C>T	c.(331-333)Cgt>Tgt	p.R111C	C1orf43_ENST00000368516.1_Missense_Mutation_p.R77C|C1orf43_ENST00000368518.1_Missense_Mutation_p.R111C|C1orf43_ENST00000350592.3_Missense_Mutation_p.R77C|C1orf43_ENST00000368519.1_Intron|C1orf43_ENST00000362076.4_Intron	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	111						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					CCAGAGGTACGAATGGCATCC	0.463000													33	137					0	0	1	0	0
VPS41	27072	broad.mit.edu	37	7	38768163	38768163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38768163G>A	ENST00000310301.4	-	27	2437	c.2383C>T	c.(2383-2385)Ctt>Ttt	p.L795F	VPS41_ENST00000395969.2_Missense_Mutation_p.L770F	NM_014396.3	NP_055211.2	P49754	VPS41_HUMAN	vacuolar protein sorting 41 homolog (S. cerevisiae)	795					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	44						ATAGGGGAAAGGCACGACTCA	0.403000													33	140					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77896092	77896092	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:77896092C>T	ENST00000262198.4	+	4	3251	c.2796C>T	c.(2794-2796)gcC>gcT	p.A932A		NM_014913.3	NP_055728.1	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	932					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CTGCCATCGCCGTCCATTTGG	0.562000													8	145					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94849449	94849449	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94849449C>T	ENST00000448921.1	-	4	698	c.126G>A	c.(124-126)caG>caA	p.Q42Q	SERPINA1_ENST00000393087.4_Silent_p.Q42Q|SERPINA1_ENST00000449399.3_Silent_p.Q42Q|SERPINA1_ENST00000437397.1_Silent_p.Q42Q|SERPINA1_ENST00000404814.4_Silent_p.Q42Q|SERPINA1_ENST00000402629.1_Silent_p.Q42Q|SERPINA1_ENST00000440909.1_Silent_p.Q42Q|SERPINA1_ENST00000355814.4_Silent_p.Q42Q|SERPINA1_ENST00000393088.4_Silent_p.Q42Q	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	42					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TTGGGTGATCCTGATCATGGT	0.577000													14	65					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19136660	19136660	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19136660G>A	ENST00000601879.1	-	3	794	c.497C>T	c.(496-498)cCc>cTc	p.P166L	SUGP2_ENST00000337018.6_Missense_Mutation_p.P166L|SUGP2_ENST00000452918.2_Missense_Mutation_p.P166L|SUGP2_ENST00000598202.1_5'UTR|SUGP2_ENST00000456085.2_Intron|SUGP2_ENST00000600377.1_Missense_Mutation_p.P180L			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	166					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						AACTGCAGAGGGACCAAAACT	0.502000													37	70					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17498204	17498204	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17498204G>A	ENST00000302539.4	-	1	245	c.120C>T	c.(118-120)ctC>ctT	p.L40L	ABCC8_ENST00000389817.3_Silent_p.L40L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	40					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGGTGATGAAGAGTAGGAAGA	0.672000													6	26					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105010414	105010414	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:105010414C>T	ENST00000507740.1	+	15	2658	c.2420_splice	c.e15-1	p.H808_splice	RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000436393.2_Splice_Site_p.H794_splice	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1076	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGCTTGCAGTCATTTTCTTAC	0.338000										HNSCC(12;0.0054)			39	74					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955629	18955629	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18955629G>A	ENST00000302797.3	-	1	927	c.703C>T	c.(703-705)Cag>Tag	p.Q235*		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	235					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AGGAAAAACTGAATGCCAAAG	0.478000													17	37					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34241738	34241738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34241738G>A	ENST00000374114.3	-	3	1770	c.1507C>T	c.(1507-1509)Cat>Tat	p.H503Y	CPNE1_ENST00000397445.1_Intron|RBM12_ENST00000359646.1_Missense_Mutation_p.H503Y|CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000317619.3_Intron|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000397446.1_Intron|RBM12_ENST00000374104.3_Missense_Mutation_p.H503Y|CPNE1_ENST00000352393.4_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	503	RRM 2.					nucleus	nucleotide binding|protein binding|RNA binding	p.H503N(1)		breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GTAATTGGATGAACTTGAATA	0.398000													60	180					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206628459	206628459	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206628459C>T	ENST00000360409.3	+	13	2897	c.2106C>T	c.(2104-2106)ctC>ctT	p.L702L	AC007362.3_ENST00000596616.1_RNA|NRP2_ENST00000540178.1_Silent_p.L702L|NRP2_ENST00000357785.5_Silent_p.L702L|AC007362.3_ENST00000598710.1_RNA|NRP2_ENST00000412873.2_Silent_p.L702L|NRP2_ENST00000272849.3_Silent_p.L702L|NRP2_ENST00000540841.1_Silent_p.L702L|AC007362.3_ENST00000423425.1_RNA|NRP2_ENST00000485684.1_3'UTR|NRP2_ENST00000357118.4_Silent_p.L702L	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	702	MAM.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						ATGCCCGGCTCATCAGCCCCC	0.622000											OREG0015155	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	111					0	0	1	0	0
FIBIN	387758	broad.mit.edu	37	11	27016596	27016596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:27016596G>A	ENST00000318627.2	+	1	969	c.523G>A	c.(523-525)Gag>Aag	p.E175K		NM_203371.1	NP_976249.1	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog (zebrafish)	175						extracellular region|Golgi apparatus				breast(1)|endometrium(2)|lung(7)|upper_aerodigestive_tract(1)	11						CCTGCTGAAGGAGACACTGGA	0.572000													27	63					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6685006	6685006	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6685006G>A	ENST00000245907.6	-	30	4054	c.3962C>T	c.(3961-3963)tCa>tTa	p.S1321L		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1321		Cleavage; by factor I.			complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TACCTCTTCTGATCGCAGGAG	0.597000													19	34					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61223558	61223558	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61223558G>A	ENST00000382768.1	+	1	166	c.166G>A	c.(166-168)Gag>Aag	p.E56K	SERPINB12_ENST00000269491.1_Missense_Mutation_p.E56K			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	56					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TCAGATTGATGAGGTACGTGT	0.498000													60	116					0	0	1	0	0
PHC2	1912	broad.mit.edu	37	1	33797043	33797043	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33797043G>A	ENST00000257118.5	-	11	1962	c.1909C>T	c.(1909-1911)Ccc>Tcc	p.P637S	PHC2_ENST00000485928.1_5'UTR|PHC2_ENST00000373418.3_Missense_Mutation_p.P102S|PHC2_ENST00000373422.3_Missense_Mutation_p.P243S|PHC2_ENST00000373416.1_Missense_Mutation_p.P102S|PHC2_ENST00000431992.1_Missense_Mutation_p.P608S|PHC2_ENST00000419414.2_Missense_Mutation_p.P638S	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	637					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGTTTGAGGGGAGCACCCTCC	0.532000													57	119					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206327507	206327507	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206327507T>G	ENST00000361052.3	+	6	829	c.711T>G	c.(709-711)atT>atG	p.I237M	CTSE_ENST00000360218.2_Missense_Mutation_p.I232M|CTSE_ENST00000468617.1_3'UTR|CTSE_ENST00000358184.2_Missense_Mutation_p.I232M|CTSE_ENST00000432969.2_Missense_Mutation_p.I157M			P14091	CATE_HUMAN	cathepsin E	237					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GCGAGCTGATTTTTGGAGGCT	0.527000													9	209					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531727	92531727	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92531727C>T	ENST00000298047.6	+	9	5565	c.5548C>T	c.(5548-5550)Cat>Tat	p.H1850Y	FAT3_ENST00000409404.2_Missense_Mutation_p.H1850Y|FAT3_ENST00000525166.1_Missense_Mutation_p.H1700Y			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1850	Cadherin 16.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTCCATTTTCATGTGCATGT	0.463000										TCGA Ovarian(4;0.039)			8	25					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735969	13735969	+	Missense_Mutation	SNP	G	G	A	rs78346432		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13735969G>A	ENST00000265104.4	-	67	11632	c.11528C>T	c.(11527-11529)tCg>tTg	p.S3843L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3843			S -> L (in CILD3).		microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTGGCGAAGCGAAGTCTGATA	0.478000									Kartagener syndrome				38	94					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91628487	91628487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91628487G>A	ENST00000375835.4	-	12	1966	c.1660C>T	c.(1660-1662)Cgg>Tgg	p.R554W		NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	554	SH2.			R -> Q (in Ref. 4; AAH26314).	central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						TCCTTTGTCCGGATCTATGAA	0.488000													5	82					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43056984	43056984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43056984G>A	ENST00000316099.3	+	9	1228	c.1139G>A	c.(1138-1140)aGc>aAc	p.S380N	HNF4A_ENST00000457232.1_Missense_Mutation_p.S358N|HNF4A_ENST00000415691.1_Missense_Mutation_p.S380N	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	380					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGGTCCCCCAGCGATGCACCC	0.597000													23	74					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640458	104640458	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104640458C>T	ENST00000304883.2	-	1	515	c.375G>A	c.(373-375)gtG>gtA	p.V125V		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	125						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AAGCCAGGTTCACAAGGAAGT	0.537000													19	57					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156909560	156909560	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156909560G>A	ENST00000368194.3	-	37	4915	c.3876C>T	c.(3874-3876)tcC>tcT	p.S1292S	ARHGEF11_ENST00000315174.8_Silent_p.S668S|ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000361409.2_Silent_p.S1252S	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1252					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTTGCCCTGGGGAGCCTGGGT	0.642000													15	43					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179611552	179611552	+	Missense_Mutation	SNP	C	C	T	rs62179016	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179611552C>T	ENST00000360870.5	-	46	15797	c.15575G>A	c.(15574-15576)aGg>aAg	p.R5192K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8711	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATACCTTCCTTTTGGTCAG	0.388000													52	100					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171546720	171546720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171546720C>T	ENST00000367742.3	+	26	7345	c.7103C>T	c.(7102-7104)tCc>tTc	p.S2368F	PRRC2C_ENST00000426496.2_Missense_Mutation_p.S2301F|PRRC2C_ENST00000338920.4_Missense_Mutation_p.S2366F|PRRC2C_ENST00000392078.3_Missense_Mutation_p.S2368F			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2366	Gln-rich.						protein C-terminus binding										TGTATGCCTTCCCTTATTGCC	0.413000													12	33					0	0	1	0	0
CFC1	55997	broad.mit.edu	37	2	131356248	131356248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131356248C>T	ENST00000259216.4	-	3	476	c.214G>A	c.(214-216)Gag>Aag	p.E72K		NM_032545.3	NP_115934.1	P0CG37	CFC1_HUMAN	cripto, FRL-1, cryptic family 1	72					determination of left/right symmetry|gastrulation	anchored to membrane|extracellular region|plasma membrane				endometrium(1)|lung(4)	5	Colorectal(110;0.1)					GGGAGCGGCTCCTCCGGCCCC	0.627000													20	135					0	0	1	0	0
ZNF92	168374	broad.mit.edu	37	7	64864215	64864215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:64864215C>T	ENST00000328747.7	+	4	1387	c.1188C>T	c.(1186-1188)ccC>ccT	p.P396P	ZNF92_ENST00000450302.2_Silent_p.P327P|ZNF92_ENST00000431504.1_Silent_p.P320P|ZNF92_ENST00000357512.2_Silent_p.P364P	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	396						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				GAGAAAAACCCTACAAATGTG	0.368000													33	78					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78513722	78513722	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:78513722G>A	ENST00000397909.2	+	15	3919	c.3746G>A	c.(3745-3747)cGa>cAa	p.R1249Q	NAV3_ENST00000266692.7_Missense_Mutation_p.R1249Q|NAV3_ENST00000536525.2_Missense_Mutation_p.R1249Q|NAV3_ENST00000228327.6_Missense_Mutation_p.R1249Q			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1249	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CCCACATTTCGAAGGTAAGGA	0.403000										HNSCC(70;0.22)			11	50					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233489572	233489572	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233489572G>A	ENST00000366624.3	+	3	1267	c.1006G>A	c.(1006-1008)Gaa>Aaa	p.E336K	MLK4_ENST00000366623.3_Missense_Mutation_p.E336K	NM_032435.2	NP_115811.2												p.E336K(1)									GCTGCTGTGGGAACTGCTCAC	0.488000													33	66					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88732726	88732726	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88732726C>T	ENST00000226284.5	+	7	685	c.618C>T	c.(616-618)gtC>gtT	p.V206V		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	206					biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		AAGAAAGTGTCACTGGAGCCA	0.537000													14	52					0	0	1	0	0
TRIM60	166655	broad.mit.edu	37	4	165962425	165962425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:165962425C>T	ENST00000512596.1	+	3	1417	c.1201C>T	c.(1201-1203)Cct>Tct	p.P401S	TRIM60_ENST00000508504.1_Missense_Mutation_p.P401S|TRIM60_ENST00000341062.5_Missense_Mutation_p.P401S	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	401	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		TGCGTCAGGTCCTAAGACAAC	0.428000													62	111					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18186640	18186640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18186640C>T	ENST00000600835.1	-	8	922	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	IL12RB1_ENST00000593993.1_Missense_Mutation_p.E207K|IL12RB1_ENST00000430026.2_Missense_Mutation_p.E207K|IL12RB1_ENST00000322153.6_Missense_Mutation_p.E207K			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	207	Fibronectin type-III 2.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						AGCTGGAATTCCTGGGCCACA	0.597000													40	76					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962516	73962516	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73962516G>A	ENST00000373468.1	-	3	2527	c.1876C>T	c.(1876-1878)Cgc>Tgc	p.R626C	KIAA2022_ENST00000055682.5_Missense_Mutation_p.R626C			Q5QGS0	K2022_HUMAN	KIAA2022	626					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TTTCGTTTGCGAGCAGGTGGC	0.413000													13	10					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53170910	53170910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53170910G>A	ENST00000332411.2	-	1	219	c.166C>T	c.(166-168)Cgc>Tgc	p.R56C		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	56	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TAGAGGCTGCGACTGCCAAAG	0.667000													47	112					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38968413	38968413	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38968413G>A	ENST00000302328.3	-	4	696	c.498C>T	c.(496-498)ttC>ttT	p.F166F	SCN11A_ENST00000456224.3_Silent_p.F166F|SCN11A_ENST00000444237.2_Silent_p.F166F|SCN11A_ENST00000450244.1_Silent_p.F166F	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	166					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAATCCCAGTGAAGACACACC	0.353000													11	127					0	0	1	0	0
PLAU	5328	broad.mit.edu	37	10	75674610	75674610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75674610G>A	ENST00000446342.1	+	8	1337	c.855G>A	c.(853-855)tcG>tcA	p.S285S	C10orf55_ENST00000412307.2_Intron|C10orf55_ENST00000409178.1_Intron|PLAU_ENST00000372764.3_Silent_p.S302S|PLAU_ENST00000372762.4_Silent_p.S266S	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	302	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	GCCTGCCCTCGATGTATAACG	0.527000													19	43					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213872705	213872705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:213872705G>A	ENST00000457361.1	-	8	1128	c.960C>T	c.(958-960)gcC>gcT	p.A320A	IKZF2_ENST00000374327.4_Silent_p.A175A|IKZF2_ENST00000342002.2_Silent_p.A326A|IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000374319.4_Silent_p.A294A|IKZF2_ENST00000421754.2_Silent_p.A246A|IKZF2_ENST00000434687.1_Silent_p.A320A|IKZF2_ENST00000451136.2_Silent_p.A248A	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CATTGTTGATGGCTTGGTCCA	0.483000													18	67					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96875242	96875242	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96875242G>A	ENST00000267584.4	+	4	506	c.462G>A	c.(460-462)acG>acA	p.T154T	AK7_ENST00000554313.1_3'UTR	NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	154					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TACTGTCGACGGTGATGACTT	0.473000													17	69					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6191187	6191187	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6191187G>A	ENST00000530810.1	-	1	451	c.370C>T	c.(370-372)Cgc>Tgc	p.R124C	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCACAAAGCGATCAAAGGCC	0.498000													26	56					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27473142	27473142	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:27473142G>A	ENST00000295736.5	-	7	840	c.770C>T	c.(769-771)tCc>tTc	p.S257F	SLC4A7_ENST00000445684.1_Missense_Mutation_p.S253F|SLC4A7_ENST00000454389.1_Missense_Mutation_p.S266F|SLC4A7_ENST00000455077.1_Intron|SLC4A7_ENST00000388777.4_5'UTR|SLC4A7_ENST00000428386.1_Intron|SLC4A7_ENST00000437179.1_Intron|SLC4A7_ENST00000435667.2_Intron|SLC4A7_ENST00000446700.1_Missense_Mutation_p.S249F|SLC4A7_ENST00000440156.1_Missense_Mutation_p.S253F|SLC4A7_ENST00000425128.2_Missense_Mutation_p.S249F	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	257						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						AGAGTGGCGGGAGGCTGAAAG	0.398000													23	74					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89398297	89398297	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89398297G>A	ENST00000439576.2	+	12	2855	c.2481G>A	c.(2479-2481)aaG>aaA	p.K827K	ACAN_ENST00000559004.1_Silent_p.K827K|ACAN_ENST00000561243.1_Silent_p.K827K|ACAN_ENST00000352105.7_Silent_p.K827K	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	827					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCCCCTCCAAGGAGCCATCCC	0.622000													6	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059860	9059860	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9059860C>T	ENST00000397910.4	-	3	27789	c.27586G>A	c.(27586-27588)Gaa>Aaa	p.E9196K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9198	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAACTGGTTTCAGGTTCTGAG	0.493000													39	75					0	0	1	0	0
CSNK1A1P1	161635	broad.mit.edu	37	15	37109956	37109956	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:37109956C>T	ENST00000430593.3	-	0	704					NR_027320.1																						GTATAAAATTCTTTGTATGCA	0.373000													16	50					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25232052	25232052	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25232052G>A	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						tgtTTTGGTGGAGTGGTAGGA	0.478000													17	45					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23080255	23080255	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23080255G>A	ENST00000219689.7	-	16	3170	c.3171C>T	c.(3169-3171)tcC>tcT	p.S1057S	USP31_ENST00000567975.1_Silent_p.S350S	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1057	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GAGAAGAAGGGGATGTACTTG	0.547000													22	78					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18113370	18113370	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18113370C>T	ENST00000403915.1	+	3	1546	c.1095C>T	c.(1093-1095)acC>acT	p.T365T	KCNS3_ENST00000465292.1_Intron|KCNS3_ENST00000304101.4_Silent_p.T365T			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	365	Segment H5 (pore-forming) (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGTGGGCCACCATCAGCATGA	0.557000													29	69					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34006240	34006240	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34006240G>A	ENST00000373381.4	-	60	9692	c.9516C>T	c.(9514-9516)ttC>ttT	p.F3172F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3148	Sushi 25.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGCCCCACATGAAGTCAGACC	0.602000													33	87					0	0	1	0	0
ADH6	130	broad.mit.edu	37	4	100134904	100134904	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100134904C>T	ENST00000394897.1	-	3	203	c.120_splice	c.e3-1	p.V41_splice	ADH6_ENST00000394899.2_Splice_Site_p.V41_splice|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000237653.7_Splice_Site_p.V41_splice|ADH6_ENST00000407820.2_Intron|RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	41					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	GTGGCCACAACCTGTATGGAA	0.468000													25	48					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48370707	48370707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48370707G>A	ENST00000395702.2	+	2	402	c.175G>A	c.(175-177)Gag>Aag	p.E59K	ZNF488_ENST00000586537.1_5'UTR|ZNF488_ENST00000494156.1_Missense_Mutation_p.E59K			Q96MN9	ZN488_HUMAN	zinc finger protein 488	59					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						CCTGGGCCCTGAGGCTGCTGT	0.677000													22	45					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42807211	42807211	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:42807211C>T	ENST00000514985.1	-	3	460		c.e3-1		SEPP1_ENST00000509276.1_Intron|SEPP1_ENST00000506577.1_Splice_Site|SEPP1_ENST00000511224.1_Splice_Site|SEPP1_ENST00000507920.1_Intron	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1						response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						GTCTTCTAATCTAAAATATTT	0.289000													18	41					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76440770	76440770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76440770G>A	ENST00000389840.5	-	71	11526	c.11402C>T	c.(11401-11403)cCc>cTc	p.P3801L	DNAH17_ENST00000585328.1_Missense_Mutation_p.P3810L|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17									p.P3810L(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCACTCCTTGGGGAAGATCTC	0.567000													9	31					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47941126	47941126	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47941126C>T	ENST00000236877.6	-	7	2385	c.1990G>A	c.(1990-1992)Gag>Aag	p.E664K	SLC8A2_ENST00000542837.1_Missense_Mutation_p.E420K|SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000539381.1_Missense_Mutation_p.E127K	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	664					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		TATGACTCCTCGATGATGACC	0.577000													45	92					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100888	93100888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:93100888C>T	ENST00000544406.2	+	2	747	c.481C>T	c.(481-483)Ccc>Tcc	p.P161S	C12orf74_ENST00000397833.3_Missense_Mutation_p.P161S			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	161										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						CCTGCCCAGCCCCACCCTACG	0.547000													7	41					0	0	1	0	0
COL23A1	91522	broad.mit.edu	37	5	177675235	177675235	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:177675235C>T	ENST00000390654.3	-	20	1527	c.1170G>A	c.(1168-1170)ggG>ggA	p.G390G		NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	390	Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CCCCCTTCTCCCCCTTGAGGC	0.647000													35	77					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389047	20389047	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20389047C>T	ENST00000315915.4	+	1	307	c.282C>T	c.(280-282)ttC>ttT	p.F94F		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F94L(1)		central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCATATCTTTCAGTGGCTGCA	0.423000													106	212					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198950722	198950722	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:198950722C>T	ENST00000428675.1	+	2	2879	c.2481C>T	c.(2479-2481)ccC>ccT	p.P827P	PLCL1_ENST00000437704.2_Silent_p.P729P	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	827					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GGCATGTTCCCCTGCGTTCTT	0.453000													29	74					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176314308	176314308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176314308C>T	ENST00000292432.5	-	12	1722	c.1631G>A	c.(1630-1632)gGg>gAg	p.G544E		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	544	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTCGTGCCCCCGAGGTCCAG	0.647000													18	39					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94377063	94377063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94377063C>T	ENST00000282020.4	+	11	2054	c.1796C>T	c.(1795-1797)tCa>tTa	p.S599L	GRID2_ENST00000510992.1_Missense_Mutation_p.S504L	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	599					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CAAATGGGATCAATGACGTCT	0.418000													24	117					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92826798	92826798	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92826798C>T	ENST00000394468.2	-	5	1215	c.1138_splice	c.e5+1	p.V380_splice	HEPACAM2_ENST00000492616.1_5'UTR|HEPACAM2_ENST00000440868.1_Splice_Site_p.G368_splice|HEPACAM2_ENST00000453812.2_Splice_Site_p.V403_splice|HEPACAM2_ENST00000341723.4_Splice_Site_p.V368_splice	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	380						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						TTTAACCTACCTTTGTAGGGT	0.269000													9	54					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56243668	56243668	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56243668G>A	ENST00000332836.2	-	2	1556	c.1529C>T	c.(1528-1530)tCc>tTc	p.S510F		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	510						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AAAACCAAAGGAGGTCTCCAG	0.443000													47	108					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40494791	40494791	+	Splice_Site	SNP	C	C	T	rs138332995		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40494791C>T	ENST00000287598.6	+	14	1825	c.1628_splice	c.e14-1	p.P544_splice	BUB1B_ENST00000412359.3_Splice_Site_p.P558_splice	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	544					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTTTTCCAGTCCTCCTGCAGA	0.378000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				32	154					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070072	9070072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9070072C>T	ENST00000397910.4	-	3	17577	c.17374G>A	c.(17374-17376)Gag>Aag	p.E5792K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5794	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGTTGATCTCCTCAGACGTC	0.458000													25	51					0	0	1	0	0
ENTPD6	955	broad.mit.edu	37	20	25201908	25201908	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:25201908C>T	ENST00000360031.2	+	11	1163	c.981C>T	c.(979-981)ccC>ccT	p.P327P	ENTPD6_ENST00000354989.5_Silent_p.P311P|ENTPD6_ENST00000433259.2_Intron|ENTPD6_ENST00000376652.4_Silent_p.P328P	NM_001247.2	NP_001238.2	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6 (putative)	328						Golgi membrane|integral to membrane	nucleoside-diphosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|prostate(1)|skin(1)	27						GCTTGTCTCCCAGTTTCAAAG	0.512000													11	60					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36149358	36149358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36149358G>A	ENST00000303965.4	-	18	3500	c.3011C>T	c.(3010-3012)cCc>cTc	p.P1004L		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1004					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						AGCAAATAAGGGAACAAAATG	0.358000													16	32					0	0	1	0	0
OR9K2	441639	broad.mit.edu	37	12	55523928	55523928	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55523928C>T	ENST00000305377.5	+	1	464	c.376C>T	c.(376-378)Ctc>Ttc	p.L126F		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						TGTGGCCCAGCTCTTTCTCTT	0.468000													18	152					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167419974	167419974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:167419974G>A	ENST00000519204.1	+	4	728	c.610G>A	c.(610-612)Ggg>Agg	p.G204R	TENM2_ENST00000403607.2_Missense_Mutation_p.G158R|TENM2_ENST00000545108.1_Missense_Mutation_p.G325R|TENM2_ENST00000518659.1_Missense_Mutation_p.G325R|TENM2_ENST00000520393.1_3'UTR|TENM2_ENST00000520394.1_Missense_Mutation_p.G134R					teneurin transmembrane protein 2																		GACCTCCTCGGGGAGCACACC	0.552000													25	73					0	0	1	0	0
OR5B17	219965	broad.mit.edu	37	11	58125676	58125676	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58125676G>A	ENST00000357377.3	-	1	866	c.867C>T	c.(865-867)acC>acT	p.T289T		NM_001005489.1	NP_001005489.1	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B, member 17	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGTTCCTCAGGGTATAGACTA	0.388000													63	136					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39724502	39724502	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39724502C>T	ENST00000246662.4	-	6	1371	c.1306G>A	c.(1306-1308)Gaa>Aaa	p.E436K	KRT9_ENST00000588431.1_Missense_Mutation_p.E203K	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	436	Coil 2.|Rod.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				AGGCTGTATTCCTGATTCTGG	0.547000													21	45					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255006	15255006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15255006C>T	ENST00000378116.4	-	8	2587	c.2581G>A	c.(2581-2583)Gaa>Aaa	p.E861K		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	861						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TCATCGTCTTCCTCTTCCTCG	0.587000													64	172					0	0	1	0	0
ALX4	60529	broad.mit.edu	37	11	44289073	44289073	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:44289073G>A	ENST00000329255.3	-	3	980	c.877C>T	c.(877-879)Ctc>Ttc	p.L293F		NM_021926.3	NP_068745.2	Q9H161	ALX4_HUMAN	ALX homeobox 4	293					hair follicle development					central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	16						CGGGTGAGGAGGGGCAGCTCA	0.622000													20	18					0	0	1	0	0
BIN2	51411	broad.mit.edu	37	12	51685950	51685950	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51685950C>T	ENST00000267012.4	-	10	1001	c.940G>A	c.(940-942)Gag>Aag	p.E314K	BIN2_ENST00000544402.1_Missense_Mutation_p.E288K|BIN2_ENST00000452142.2_Missense_Mutation_p.E282K|BIN2_ENST00000604560.1_Missense_Mutation_p.E287K	NM_016293.2	NP_057377.2	Q9UBW5	BIN2_HUMAN	bridging integrator 2	314						cytoplasm	protein binding			NS(2)|breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(3)	31						TCTAAGAGCTCCTTGATCTCA	0.517000													27	66					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125315672	125315672	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125315672C>T	ENST00000373688.2	+	1	282	c.224C>T	c.(223-225)cCc>cTc	p.P75L		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						CTCCATACTCCCATGTACTTC	0.507000													29	203					0	0	1	0	0
AMZ1	155185	broad.mit.edu	37	7	2740316	2740316	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2740316C>T	ENST00000312371.4	+	2	599	c.231C>T	c.(229-231)ttC>ttT	p.F77F	AMZ1_ENST00000407112.1_Silent_p.F77F	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	77							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CCGAGGACTTCCAGACCTTCC	0.667000													28	109					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018542	62018542	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62018542G>A	ENST00000578147.1	-	24	5176	c.5100C>T	c.(5098-5100)acC>acT	p.T1700T	SCN4A_ENST00000435607.1_Silent_p.T1700T			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1700					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.T1700T(1)		breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TCTCCTCCATGGTCTGCTTGA	0.587000													22	66					0	0	1	0	0
G6PC	2538	broad.mit.edu	37	17	41059569	41059569	+	Missense_Mutation	SNP	G	G	A	rs104894568		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:41059569G>A	ENST00000253801.2	+	3	449	c.370G>A	c.(370-372)Gca>Aca	p.A124T	G6PC_ENST00000592383.1_Intron|G6PC_ENST00000585489.1_Missense_Mutation_p.A124T	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	124			A -> T (in GSD1A).		gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CATGGGCACAGCAGGTGTATA	0.498000													20	29					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124325875	124325875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124325875G>A	ENST00000409039.3	+	29	4814	c.4789G>A	c.(4789-4791)Gac>Aac	p.D1597N		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1597	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCAGATGTACGACAACATAGC	0.512000													22	179					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584835	179584835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179584835G>A	ENST00000589042.1	-	81	23758	c.23534C>T	c.(23533-23535)tCa>tTa	p.S7845L	TTN_ENST00000342992.6_Missense_Mutation_p.S6601L|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.S7528L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7528	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCAATGAATGAAATCCTGGT	0.428000													10	86					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41181551	41181551	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41181551G>A	ENST00000263413.3	-	7	1101	c.837C>T	c.(835-837)ttC>ttT	p.F279F	C6_ENST00000337836.5_Silent_p.F279F|C6_ENST00000475349.1_5'UTR	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	279	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTGGTACACTGAAAGAGCTCC	0.368000													38	78					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23818459	23818459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:23818459G>A	ENST00000546136.1	-	6	813	c.811C>T	c.(811-813)Cct>Tct	p.P271S	SOX5_ENST00000537393.1_Missense_Mutation_p.P249S|SOX5_ENST00000541536.1_Missense_Mutation_p.P271S|SOX5_ENST00000451604.2_Missense_Mutation_p.P284S|SOX5_ENST00000381381.2_Missense_Mutation_p.P271S|SOX5_ENST00000545921.1_Missense_Mutation_p.P274S|SOX5_ENST00000309359.1_Missense_Mutation_p.P271S			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	284					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						TGATCAGGAGGGAATACGGGA	0.493000													18	130					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531592	50531592	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50531592A>T	ENST00000374144.3	+	3	1290	c.1002A>T	c.(1000-1002)gaA>gaT	p.E334D	C10orf71_ENST00000323868.4_Missense_Mutation_p.E334D			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	334										endometrium(1)	1						GCAGTCAGGAAGAGAACAGAC	0.582000													11	54					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6750520	6750520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:6750520C>T	ENST00000230859.6	+	10	1143	c.1014C>T	c.(1012-1014)ccC>ccT	p.P338P		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	338					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding	p.P338P(1)		cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CCGAGTCTCCCTATGGCCAGC	0.552000													25	57					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42554560	42554560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42554560C>T	ENST00000381668.5	-	17	1712	c.1481G>A	c.(1480-1482)cGa>cAa	p.R494Q	ATP8A1_ENST00000264449.10_Missense_Mutation_p.R479Q	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	494					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	GTCACCTTCTCGCTCTGGCAC	0.363000													31	75					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873438	55873438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55873438G>A	ENST00000313503.1	+	1	920	c.920G>A	c.(919-921)aGa>aAa	p.R307K		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					GTCATGCAGAGAAGACAGGAC	0.353000										HNSCC(53;0.14)			42	121					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45152068	45152068	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45152068C>T	ENST00000296129.1	-	4	1055	c.921G>A	c.(919-921)ggG>ggA	p.G307G	CDCP1_ENST00000425231.2_Silent_p.G307G	NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	307						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		GGTTGAAGTTCCCCGCCATGT	0.552000													41	109					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227985818	227985818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227985818C>T	ENST00000396625.3	-	5	446	c.239G>A	c.(238-240)gGa>gAa	p.G80E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G80E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	80	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCCTGGGGCTCCCAGGGGTCC	0.547000													11	45					0	0	1	0	0
FIBCD1	84929	broad.mit.edu	37	9	133799149	133799149	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133799149C>T	ENST00000372338.4	-	4	1073	c.831G>A	c.(829-831)acG>acA	p.T277T	FIBCD1_ENST00000253018.4_Silent_p.T119T|FIBCD1_ENST00000448616.1_Silent_p.T277T|FIBCD1_ENST00000372337.2_Silent_p.T119T	NM_032843.4	NP_116232.3	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	277	Fibrinogen C-terminal.				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CGCCGCCGTCCGTGCGCATGT	0.672000													8	28					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5020937	5020937	+	Silent	SNP	G	G	A	rs142184899	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5020937G>A	ENST00000382545.3	+	2	1500	c.393G>A	c.(391-393)cgG>cgA	p.R131R	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	131					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGAAGTTCCGGGAGGACGAGG	0.652000													40	65					0	0	1	0	0
ACAD10	80724	broad.mit.edu	37	12	112185104	112185104	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:112185104C>T	ENST00000455480.2	+	17	2670	c.2493C>T	c.(2491-2493)gcC>gcT	p.A831A	ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000392636.2_Silent_p.A402A|ACAD10_ENST00000313698.4_Silent_p.A800A	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	800							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						CTCAGGTTGCCTCTTCAGATG	0.542000													40	57					0	0	1	0	0
NIPAL4	348938	broad.mit.edu	37	5	156899773	156899773	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156899773C>T	ENST00000311946.7	+	6	1322	c.1206C>T	c.(1204-1206)ttC>ttT	p.F402F	ADAM19_ENST00000430702.2_Intron|NIPAL4_ENST00000435489.2_Silent_p.F383F	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	402						integral to membrane	receptor activity	p.F340L(2)		breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						TGGGCGTGTTCATGCTGCATG	0.547000													15	39					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188904	32188904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32188904G>A	ENST00000375023.3	-	4	788	c.650C>T	c.(649-651)tCc>tTc	p.S217F		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	217	EGF-like 5; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GCACTGGAAGGAGCCCAGGGT	0.657000													22	31					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64504414	64504414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64504414C>T	ENST00000377494.1	-	8	1828	c.906G>A	c.(904-906)ccG>ccA	p.P302P	RASGRP2_ENST00000354024.3_Silent_p.P302P|RASGRP2_ENST00000377497.3_Silent_p.P302P|RASGRP2_ENST00000394432.3_Silent_p.P302P			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	302	Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CACCCAGGATCGGGAAGCGGA	0.662000													8	38					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921236	24921236	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24921236C>T	ENST00000329468.2	+	1	696	c.222C>T	c.(220-222)ctC>ctT	p.L74L		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CGTGTCCTCTCCCTCGGGCTG	0.711000													15	38					0	0	1	0	0
IGFL3	388555	broad.mit.edu	37	19	46627344	46627344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46627344G>A	ENST00000341415.2	-	3	173	c.149C>T	c.(148-150)cCt>cTt	p.P50L	AC007193.6_ENST00000597989.1_lincRNA	NM_207393.1	NP_997276.1	Q6UXB1	IGFL3_HUMAN	IGF-like family member 3	50						extracellular region	protein binding			endometrium(1)|large_intestine(1)|lung(5)	7		Ovarian(192;0.0175)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00473)|GBM - Glioblastoma multiforme(486;0.0149)|Epithelial(262;0.239)		CTGCTCTGAAGGGTTGTAGAT	0.557000													44	104					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73045805	73045805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:73045805C>T	ENST00000545377.1	+	3	353	c.177C>T	c.(175-177)gtC>gtT	p.V59V	ARHGEF28_ENST00000426542.2_Silent_p.V59V|ARHGEF28_ENST00000437974.1_Silent_p.V59V|ARHGEF28_ENST00000513042.2_Silent_p.V59V|ARHGEF28_ENST00000287898.5_Silent_p.V59V|ARHGEF28_ENST00000296794.6_Silent_p.V59V	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		AGTCCAGCGTCCCAGGTGAGG	0.483000													18	81					0	0	1	0	0
ROR1	4919	broad.mit.edu	37	1	64643413	64643413	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:64643413C>T	ENST00000371079.1	+	9	2064	c.1689C>T	c.(1687-1689)ttC>ttT	p.F563F	ROR1_ENST00000545203.1_Silent_p.F14F	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	563	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						TCCATGAGTTCCTCATCATGA	0.488000													22	70					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180041160	180041160	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180041160C>T	ENST00000261937.6	-	24	3317	c.3239G>A	c.(3238-3240)tGg>tAg	p.W1080*	FLT4_ENST00000393347.3_Nonsense_Mutation_p.W1080*|FLT4_ENST00000502649.1_Nonsense_Mutation_p.W1080*	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1080	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGGGGCCATCCACTTCAGGGG	0.617000													32	81					0	0	1	0	0
SFN	2810	broad.mit.edu	37	1	27190435	27190435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27190435G>A	ENST00000339276.4	+	1	803	c.732G>A	c.(730-732)caG>caA	p.Q244Q		NM_006142.3	NP_006133.1	P31947	1433S_HUMAN	stratifin	244					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(2)	9		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		AGGCTCCCCAGGAGCCCCAGA	0.677000													20	36					0	0	1	0	0
AGT	183	broad.mit.edu	37	1	230846180	230846180	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:230846180G>A	ENST00000366667.4	-	2	631	c.417C>T	c.(415-417)gtC>gtT	p.V139V		NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	139					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	GGGTGCCAAAGACAGCCGTTG	0.582000													45	87					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57257852	57257852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57257852C>T	ENST00000343433.6	-	2	714	c.634G>A	c.(634-636)Gat>Aat	p.D212N	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	212										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						AAAGAGGGATCTTCAGAGACG	0.502000													57	136					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39114782	39114782	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39114782C>T	ENST00000379907.4	+	19	2209	c.2082C>T	c.(2080-2082)ctC>ctT	p.L694L	ADAM32_ENST00000437682.2_Silent_p.L595L|ADAM32_ENST00000519315.1_Silent_p.L588L	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	694					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TTCCTATTCTCATTGTAACAA	0.388000													26	78					0	0	1	0	0
ACER3	55331	broad.mit.edu	37	11	76709843	76709843	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76709843C>T	ENST00000532485.1	+	7	579	c.475C>T	c.(475-477)Cga>Tga	p.R159*	ACER3_ENST00000538157.1_Nonsense_Mutation_p.R117*|ACER3_ENST00000526597.1_Nonsense_Mutation_p.R64*|ACER3_ENST00000544113.1_Nonsense_Mutation_p.R26*|ACER3_ENST00000533873.1_Nonsense_Mutation_p.R122*	NM_018367.5	NP_060837.3	Q9NUN7	ACER3_HUMAN	alkaline ceramidase 3	159					ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)	9						ATTAGTACTTCGATCTATTTA	0.323000													9	34					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51974734	51974734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51974734G>A	ENST00000220478.3	+	2	506	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	SCG3_ENST00000542355.2_Intron	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	35					platelet activation|platelet degranulation	extracellular region|stored secretory granule		p.E35K(1)		breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		ACATAATAGAGAATTAAGTGC	0.239000													4	53					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51921498	51921498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51921498C>T	ENST00000371117.3	-	18	1966	c.1691G>A	c.(1690-1692)cGa>cAa	p.R564Q	PKHD1_ENST00000340994.4_Missense_Mutation_p.R564Q	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	564					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GACAGCACCTCGTTCAAATCC	0.408000													39	91					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888235	38888235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38888235C>T	ENST00000302328.3	-	26	5524	c.5326G>A	c.(5326-5328)Gga>Aga	p.G1776R	SCN11A_ENST00000456224.3_Missense_Mutation_p.G1738R|SCN11A_ENST00000450244.1_Missense_Mutation_p.G1776R	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1776					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GACAAGTCTCCATTGCAAAGA	0.532000													34	77					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12184860	12184860	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12184860C>T	ENST00000439326.3	+	2	193	c.18C>T	c.(16-18)ttC>ttT	p.F6F	ZNF844_ENST00000441304.2_Silent_p.F6F	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	6	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						TGGTGGCTTTCGAGGATGTGG	0.498000													51	98					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20665616	20665616	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20665616C>T	ENST00000357366.3	+	1	122	c.122C>T	c.(121-123)cCc>cTc	p.P41L		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTCAACAGCCCCAGCAACTCC	0.473000													8	47					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27728588	27728588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27728588G>A	ENST00000264717.2	+	10	817	c.754G>A	c.(754-756)Gag>Aag	p.E252K	GCKR_ENST00000424318.2_Missense_Mutation_p.E62K	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	252	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					TCTTCAGCCCGAGGGTCTCAG	0.542000													30	69					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34889177	34889177	+	Splice_Site	SNP	G	G	A	rs149024595		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34889177G>A	ENST00000360581.1	+	9	1154	c.1025_splice	c.e9-1	p.R342_splice	NPSR1_ENST00000381542.1_Splice_Site_p.R276_splice|NPSR1_ENST00000381539.3_Splice_Site_p.G376_splice|NPSR1_ENST00000359791.1_Intron|NPSR1_ENST00000531252.1_Intron	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	342						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity	p.R342R(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CTTTCTCCAGGGAGCAAAGAT	0.408000													27	86					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086445	92086445	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92086445C>T	ENST00000298047.6	+	1	1184	c.1167C>T	c.(1165-1167)tcC>tcT	p.S389S	FAT3_ENST00000541502.1_Silent_p.S389S|FAT3_ENST00000409404.2_Silent_p.S389S|FAT3_ENST00000525166.1_Silent_p.S239S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	389	Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGAATTTTCCCCTCCTGGTG	0.403000										TCGA Ovarian(4;0.039)			11	20					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42145908	42145908	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42145908C>T	ENST00000502486.1	-	3	1170	c.591G>A	c.(589-591)atG>atA	p.M197I	BEND4_ENST00000504360.1_Missense_Mutation_p.M193I	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	197										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						CGCAAGAAATCATGGACTGAG	0.478000													6	17					0	0	1	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545895	234545895	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234545895G>A	ENST00000344644.5	+	1	796	c.727G>A	c.(727-729)Gat>Aat	p.D243N	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Missense_Mutation_p.D243N	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		CACGGCATATGATCTCTACAG	0.433000													50	566					0	0	1	0	0
PPM1B	5495	broad.mit.edu	37	2	44429000	44429000	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:44429000C>T	ENST00000378551.2	+	2	1074	c.662C>T	c.(661-663)tCt>tTt	p.S221F	PPM1B_ENST00000282412.4_Missense_Mutation_p.S221F|PPM1B_ENST00000345249.4_Intron|PPM1B_ENST00000409432.3_Missense_Mutation_p.S221F|PPM1B_ENST00000378540.4_3'UTR|PPM1B_ENST00000409895.4_Missense_Mutation_p.S221F	NM_177968.2	NP_808907.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	221					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAACTTGTTTCTCCAGAGCCT	0.423000													24	58					0	0	1	0	0
WEE2	494551	broad.mit.edu	37	7	141408673	141408673	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141408673C>T	ENST00000397541.2	+	1	521	c.115C>T	c.(115-117)Caa>Taa	p.Q39*	WEE2-AS1_ENST00000488785.1_RNA	NM_001105558.1	NP_001099028.1	P0C1S8	WEE2_HUMAN	WEE1 homolog 2 (S. pombe)	39					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31	Melanoma(164;0.0171)					GGCTTCGAGCCAAACCCCAGA	0.468000													57	201					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187205268	187205268	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187205268C>T	ENST00000264692.4	+	11	1335	c.1002C>T	c.(1000-1002)ccC>ccT	p.P334P	F11_ENST00000403665.2_Silent_p.P386P			P03951	FA11_HUMAN	coagulation factor XI	386	Apple 4.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	AAATCAAGCCCAGGATCGTTG	0.517000													29	79					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57522853	57522853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57522853G>A	ENST00000420713.1	+	3	353	c.241G>A	c.(241-243)Gag>Aag	p.E81K		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						AAAGAGAAATGAGATGGTAGC	0.408000													32	114					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29429872	29429872	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29429872A>C	ENST00000377136.1	+	4	791	c.326A>C	c.(325-327)gAg>gCg	p.E109A	OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377133.1_Missense_Mutation_p.E109A|OR2H1_ENST00000442615.1_Missense_Mutation_p.E109A|OR2H1_ENST00000396792.2_Missense_Mutation_p.E109A|OR2H1_ENST00000377132.1_Missense_Mutation_p.E109A			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						GGGACCACTGAGTGCATCCTC	0.602000													15	146					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30674574	30674574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30674574G>A	ENST00000534862.1	+	10	1282	c.919G>A	c.(919-921)Gag>Aag	p.E307K	HCK_ENST00000375862.2_Missense_Mutation_p.E326K|HCK_ENST00000520553.1_Missense_Mutation_p.E306K|HCK_ENST00000375852.2_Missense_Mutation_p.E327K|HCK_ENST00000518730.1_Missense_Mutation_p.E305K|HCK_ENST00000538448.1_Missense_Mutation_p.E306K	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	327	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGTCACCAAGGAGCCCATCTA	0.592000													20	54					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86340354	86340354	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86340354C>T	ENST00000370571.2	-	35	3482	c.3116G>A	c.(3115-3117)gGa>gAa	p.G1039E	COL24A1_ENST00000436319.1_Missense_Mutation_p.G1039E	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1039	Collagen-like 9.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTCCCCAGTTCCTCCAACACT	0.438000													14	34					0	0	1	0	0
GDF3	9573	broad.mit.edu	37	12	7848085	7848085	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7848085C>T	ENST00000329913.3	-	1	287	c.240G>A	c.(238-240)ggG>ggA	p.G80G		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	80					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						GAAGTACATTCCCGCGGACGC	0.488000													36	65					0	0	1	0	0
CARNS1	57571	broad.mit.edu	37	11	67191785	67191785	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67191785C>T	ENST00000445895.2	+	9	2680	c.2566C>T	c.(2566-2568)Cgt>Tgt	p.R856C	CARNS1_ENST00000531040.1_Missense_Mutation_p.R830C|CARNS1_ENST00000307823.3_Missense_Mutation_p.R733C|CARNS1_ENST00000423745.2_Missense_Mutation_p.R733C			A5YM72	CRNS1_HUMAN	carnosine synthase 1	733					carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)	11						CCCACGTGCTCGTGGCCATCT	0.657000													3	22					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29274634	29274634	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29274634C>T	ENST00000377160.2	+	1	232	c.168C>T	c.(166-168)ccC>ccT	p.P56P		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						TCCATTCCCCCATGTATTACT	0.468000													50	173					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307789	14307789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:14307789C>T	ENST00000378053.3	-	2	620	c.364G>A	c.(364-366)Gat>Aat	p.D122N	MACROD2_ENST00000217246.4_Intron|FLRT3_ENST00000341420.4_Missense_Mutation_p.D122N|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	122					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GAAAGTGAATCATAAGTGATA	0.358000													49	118					0	0	1	0	0
USP51	158880	broad.mit.edu	37	X	55513531	55513531	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:55513531G>A	ENST00000500968.3	-	2	1924	c.1842C>T	c.(1840-1842)tcC>tcT	p.S614S	USP51_ENST00000586165.1_5'UTR	NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	614					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						CCAAGGGAAAGGAGATAAAGG	0.433000													7	22					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58134543	58134543	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58134543G>A	ENST00000357272.4	+	36	6220	c.6055G>A	c.(6055-6057)Gag>Aag	p.E2019K	FLNB_ENST00000358537.3_Missense_Mutation_p.E1995K|FLNB_ENST00000295956.4_Missense_Mutation_p.E2019K|FLNB_ENST00000429972.2_Missense_Mutation_p.E2008K|FLNB_ENST00000490882.1_Missense_Mutation_p.E2050K|FLNB_ENST00000348383.5_Missense_Mutation_p.E2019K|FLNB_ENST00000419752.2_Missense_Mutation_p.E1839K|FLNB_ENST00000493452.1_Missense_Mutation_p.E1826K			O75369	FLNB_HUMAN	filamin B, beta	2019	Interaction with the cytoplasmic tail of GP1BA.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCGGACTTTCGAGATGTCTGA	0.597000													23	59					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150883947	150883947	+	Missense_Mutation	SNP	C	C	T	rs104886490	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150883947C>T	ENST00000422024.1	-	1	531	c.406G>A	c.(406-408)Gac>Aac	p.D136N	ASB10_ENST00000275838.1_Missense_Mutation_p.D91N|ASB10_ENST00000434669.1_Missense_Mutation_p.D136N|ASB10_ENST00000420175.2_Missense_Mutation_p.D91N|ASB10_ENST00000377867.3_Intron	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	91					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCTCTGGGTCGCTGGTATCA	0.637000													7	27					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39224351	39224351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39224351C>T	ENST00000333039.2	-	2	914	c.791G>A	c.(790-792)aGg>aAg	p.R264K		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	264						integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					CACTTCCTGCCTCTGCCGGCG	0.652000													22	42					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52698736	52698736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52698736C>T	ENST00000293525.5	+	4	712	c.660C>T	c.(658-660)ctC>ctT	p.L220L	KRT86_ENST00000544024.1_Silent_p.L220L|KRT86_ENST00000423955.2_Silent_p.L220L	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	220	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCGCCTACCTCCGCAAATCAG	0.597000													46	187					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87373272	87373272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:87373272G>A	ENST00000327946.7	-	15	2578	c.2493C>T	c.(2491-2493)ttC>ttT	p.F831F	GRID1_ENST00000536331.1_Silent_p.F402F	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	831						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AGACCCCGGCGAAGCTGTGCA	0.652000										Multiple Myeloma(13;0.14)			21	51					0	0	1	0	0
FXYD5	53827	broad.mit.edu	37	19	35660507	35660507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35660507C>T	ENST00000342879.3	+	8	1304	c.526C>T	c.(526-528)Cgt>Tgt	p.R176C	FXYD5_ENST00000392217.3_Missense_Mutation_p.R105C|FXYD5_ENST00000590686.1_Missense_Mutation_p.R176C|FXYD5_ENST00000588699.1_3'UTR|FXYD5_ENST00000591716.2_3'UTR|FXYD5_ENST00000541435.2_Missense_Mutation_p.R176C|FXYD5_ENST00000423817.3_Missense_Mutation_p.R176C|FXYD5_ENST00000392219.2_Missense_Mutation_p.R176C			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	176			R -> H (in dbSNP:rs12110).		microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			ATGCCGGAATCGTTGCAGGTG	0.562000													12	25					0	0	1	0	0
ZNF878	729747	broad.mit.edu	37	19	12155097	12155097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12155097C>T	ENST00000602107.1	-	5	1259	c.1260G>A	c.(1258-1260)ggG>ggA	p.G420G	CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591898.1_RNA|CTD-2006C1.2_ENST00000591838.1_RNA|ZNF878_ENST00000547628.1_Silent_p.G373G|CTD-2006C1.2_ENST00000476474.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TGAAGGTTTTCCCACATTGTT	0.398000													16	60					0	0	1	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378278	31378278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31378278G>A	ENST00000297142.3	-	2	927	c.605C>T	c.(604-606)tCa>tTa	p.S202L		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	202					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						AGAGTAGGGTGACCTTGTGTG	0.557000													19	79					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57372396	57372396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57372396G>A	ENST00000361249.3	+	8	1249	c.1153G>A	c.(1153-1155)Gaa>Aaa	p.E385K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	385	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CATTCAATATGAAGACAAAAT	0.388000													73	124					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71391399	71391399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:71391399C>T	ENST00000392650.3	-	25	3487	c.3487G>A	c.(3487-3489)Gag>Aag	p.E1163K	SDK2_ENST00000388726.3_Missense_Mutation_p.E1163K	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1163	Fibronectin type-III 6.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TCCAGGTCCTCGATGGTGTAG	0.647000													12	26					0	0	1	0	0
SRRM3	222183	broad.mit.edu	37	7	75894779	75894779	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:75894779C>T	ENST00000388802.4	+	10	1032	c.823C>T	c.(823-825)Ccc>Tcc	p.P275S	SRRM3_ENST00000464752.1_3'UTR|SRRM3_ENST00000326382.8_Missense_Mutation_p.P275S					serine/arginine repetitive matrix 3											NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)	8						TTCCAGATCTCCCAGCAGGTA	0.632000													15	41					0	0	1	0	0
HCN2	610	broad.mit.edu	37	19	603589	603589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:603589C>T	ENST00000251287.2	+	2	731	c.678C>T	c.(676-678)ctC>ctT	p.L226L		NM_001194.3	NP_001185.3	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	226					cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			endometrium(5)|lung(4)	9		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGAAACCTCATCATCATCC	0.612000													13	28					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401879	89401879	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89401879C>T	ENST00000439576.2	+	12	6437	c.6063C>T	c.(6061-6063)gcC>gcT	p.A2021A	ACAN_ENST00000559004.1_Silent_p.A2021A|ACAN_ENST00000561243.1_Silent_p.A2021A|ACAN_ENST00000352105.7_Silent_p.A2021A	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2021					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCTCTGTAGCCATGGGCACCA	0.502000													30	41					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88769450	88769450	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88769450G>A	ENST00000444431.1	+	0	4050				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GGAGGTGAACGAGACCTGTGG	0.672000													64	130					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018533	161018533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161018533C>T	ENST00000368013.3	-	12	2598	c.2278G>A	c.(2278-2280)Gaa>Aaa	p.E760K	ARHGAP30_ENST00000368015.1_Missense_Mutation_p.E583K|ARHGAP30_ENST00000368016.3_Intron	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	760	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			ACCTGGGCTTCCTCTCTTTGT	0.483000													95	243					0	0	1	0	0
ACTR5	79913	broad.mit.edu	37	20	37400247	37400247	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:37400247C>T	ENST00000243903.4	+	9	1649	c.1612C>T	c.(1612-1614)Cgt>Tgt	p.R538C		NM_024855.3	NP_079131.3	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog (yeast)	538					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding			kidney(2)|large_intestine(2)|liver(1)|lung(5)|skin(2)	12		Myeloproliferative disorder(115;0.00878)				GTACGGTGCTCGTGACTGGGC	0.507000													30	73					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17412148	17412148	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17412148C>T	ENST00000494857.1	+	8	1353	c.1135C>T	c.(1135-1137)Caa>Taa	p.Q379*	SLC7A2_ENST00000470360.1_Intron|SLC7A2_ENST00000522656.1_Nonsense_Mutation_p.Q379*|SLC7A2_ENST00000398090.3_Intron|SLC7A2_ENST00000004531.10_Nonsense_Mutation_p.Q419*	NM_001008539.3	NP_001008539.3	P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	379					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	ATGTCTAGCTCAAATCAATTC	0.418000													59	171					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57883740	57883740	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57883740C>T	ENST00000262027.5	+	5	610	c.476C>T	c.(475-477)cCc>cTc	p.P159L	MARS_ENST00000315473.5_Intron|MARS_ENST00000447721.2_Intron	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	159	GST C-terminal.				methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CTGCAAGATCCCGCCTACCTC	0.473000													48	171					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467458	10467458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10467458C>T	ENST00000382483.3	-	4	4373	c.4150G>A	c.(4150-4152)Gga>Aga	p.G1384R		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1384					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCTTGCAGTCCTCCTTCTGGC	0.527000													123	360					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119978560	119978560	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:119978560G>C	ENST00000307142.4	+	5	3453	c.3257G>C	c.(3256-3258)aGt>aCt	p.S1086T	SYNPO2_ENST00000448416.2_Missense_Mutation_p.V88L	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	716						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TTTTAGGAGAGTGGGCGCTCC	0.408000													21	55					0	0	1	0	0
ARAP3	64411	broad.mit.edu	37	5	141059121	141059121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141059121G>A	ENST00000239440.4	-	4	754	c.689C>T	c.(688-690)gCt>gTt	p.A230V	ARAP3_ENST00000508305.1_Missense_Mutation_p.A152V	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	230					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						CCTGTGTTCAGCCCTGCCCTG	0.537000													21	67					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70960308	70960308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70960308C>T	ENST00000334414.6	-	15	3855	c.3811G>A	c.(3811-3813)Gaa>Aaa	p.E1271K	PTPRB_ENST00000550857.1_Missense_Mutation_p.E963K|PTPRB_ENST00000451516.2_Missense_Mutation_p.E963K|PTPRB_ENST00000551525.1_Missense_Mutation_p.E1270K|PTPRB_ENST00000550358.1_Missense_Mutation_p.E1183K|PTPRB_ENST00000538708.1_Intron|PTPRB_ENST00000261266.5_Missense_Mutation_p.E1053K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1053	Fibronectin type-III 15.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTTAGATCTTCAAATTTGTGT	0.448000													33	30					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	408507	408507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:408507G>A	ENST00000280886.6	-	22	2804	c.2717C>T	c.(2716-2718)tCt>tTt	p.S906F	DIP2C_ENST00000381496.3_3'UTR|DIP2C_ENST00000540204.1_Missense_Mutation_p.S227F	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	906						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGGTGCAGAGAGCCCTCCAG	0.542000													16	88					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42531877	42531877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:42531877G>A	ENST00000282030.5	+	4	2868	c.2572G>A	c.(2572-2574)Gag>Aag	p.E858K		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	858						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCCTGTGAGCGAGTCCCACAG	0.572000									Schinzel-Giedion syndrome				13	31					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66811158	66811158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66811158C>T	ENST00000393946.2	+	8	1833	c.671C>T	c.(670-672)cCc>cTc	p.P224L	SYT12_ENST00000527043.1_Missense_Mutation_p.P224L|SYT12_ENST00000525457.1_Missense_Mutation_p.P224L			Q8IV01	SYT12_HUMAN	synaptotagmin XII	224	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						TTCTCCATCCCCCTGGATCCC	0.567000													43	97					0	0	1	0	0
PPP1R32	220004	broad.mit.edu	37	11	61249308	61249308	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61249308C>T	ENST00000338608.2	+	2	152	c.27C>T	c.(25-27)gtC>gtT	p.V9V	PPP1R32_ENST00000432063.2_Silent_p.V9V|RP11-286N22.8_ENST00000543044.1_3'UTR|RP11-286N22.8_ENST00000544880.1_Intron	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	9																	CCCTGGGGGTCGTCTCCCCTT	0.637000													5	30					0	0	1	0	0
INSIG1	3638	broad.mit.edu	37	7	155094485	155094485	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:155094485C>T	ENST00000340368.4	+	5	944	c.733C>T	c.(733-735)Cgt>Tgt	p.R245C	INSIG1_ENST00000342407.5_Silent_p.F147F|INSIG1_ENST00000344756.4_Missense_Mutation_p.R93C	NM_005542.4	NP_005533.2	O15503	INSI1_HUMAN	insulin induced gene 1	245					cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	19	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCTATATTCGTTCTTGGCT	0.418000													58	112					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87018049	87018049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:87018049G>A	ENST00000398399.2	-	3	991	c.628C>T	c.(628-630)Cct>Tct	p.P210S	VGLL3_ENST00000383698.3_Missense_Mutation_p.P210S	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GATGTCAAAGGATAAGGCCAG	0.602000													21	123					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82034431	82034431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:82034431G>A	ENST00000328945.5	-	2	160	c.33C>T	c.(31-33)gtC>gtT	p.V11V	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	11					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CTGTAATGAGGACACTTTCCT	0.378000													15	54					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164371	150164371	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150164371G>A	ENST00000307271.3	+	2	1159	c.585G>A	c.(583-585)acG>acA	p.T195T		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	195						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TGGTGAATACGAACGGAGGAC	0.423000													49	92					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77442766	77442766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77442766C>T	ENST00000451710.3	-	7	1006	c.769G>A	c.(769-771)Ggc>Agc	p.G257S	TRPM6_ENST00000376864.4_Missense_Mutation_p.G257S|TRPM6_ENST00000449912.2_Missense_Mutation_p.G252S|TRPM6_ENST00000359047.2_Missense_Mutation_p.G257S|TRPM6_ENST00000360774.1_Missense_Mutation_p.G257S|TRPM6_ENST00000376871.3_Missense_Mutation_p.G257S|TRPM6_ENST00000361255.3_Missense_Mutation_p.G252S|TRPM6_ENST00000376872.3_Missense_Mutation_p.G257S|TRPM6_ENST00000483186.1_5'UTR			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	257					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CCATACTTGCCCACGGTCCCA	0.517000													10	89					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209799047	209799047	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209799047G>A	ENST00000391911.1	-	13	2311	c.1922C>T	c.(1921-1923)cCc>cTc	p.P641L	LAMB3_ENST00000356082.4_Missense_Mutation_p.P641L|LAMB3_ENST00000367030.3_Missense_Mutation_p.P641L	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	641	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TGTGACTGCGGGGCTGCTGAG	0.587000													32	85					0	0	1	0	0
ESRRA	2101	broad.mit.edu	37	11	64074765	64074765	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64074765C>T	ENST00000405666.1	+	2	348	c.114C>T	c.(112-114)gcC>gcT	p.A38A	ESRRA_ENST00000406310.1_Silent_p.A38A|ESRRA_ENST00000000442.6_Silent_p.A38A			P11474	ERR1_HUMAN	estrogen-related receptor alpha	38	Repressor domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14						TGGCCCTGGCCCCTGGTCCAG	0.667000													14	30					0	0	1	0	0
WDR77	79084	broad.mit.edu	37	1	111983920	111983920	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111983920G>A	ENST00000235090.5	-	10	1167	c.961C>T	c.(961-963)Cag>Tag	p.Q321*	WDR77_ENST00000411751.2_Nonsense_Mutation_p.Q257*|WDR77_ENST00000497278.1_5'UTR	NM_024102.2	NP_077007.1	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	321				LTTVGWDHQVVHHVVPTEPLPAPGPASVTE -> DLQVLLS RLDLRQKASPP (in Ref. 7; AAH09411).	ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGGACGACCTGATGGTCCCAG	0.527000													39	81					0	0	1	0	0
RARB	5915	broad.mit.edu	37	3	25216031	25216031	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:25216031C>T	ENST00000404969.1	+	1	143	c.143C>T	c.(142-144)cCg>cTg	p.P48L				P10826	RARB_HUMAN	retinoic acid receptor, beta	48	Modulating.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|kidney(1)|large_intestine(10)|lung(11)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	28					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	CATGGACATCCGCCTCCGAGT	0.557000													23	68					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21225122	21225122	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21225122G>A	ENST00000233242.1	-	29	13299	c.13172C>T	c.(13171-13173)cCa>cTa	p.P4391L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4391					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACTATACTTGGATCAAAATA	0.363000													33	69					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38616851	38616851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38616851G>A	ENST00000413689.1	-	20	3796	c.3603C>T	c.(3601-3603)atC>atT	p.I1201I	SCN5A_ENST00000423572.2_Silent_p.I1200I|SCN5A_ENST00000425664.1_Silent_p.I1201I|SCN5A_ENST00000455624.2_Silent_p.I1200I|SCN5A_ENST00000450102.2_Silent_p.I1147I|SCN5A_ENST00000449557.2_Silent_p.I1147I|SCN5A_ENST00000414099.2_Silent_p.I1201I|SCN5A_ENST00000451551.2_Silent_p.I1147I|SCN5A_ENST00000333535.4_Silent_p.I1201I|SCN5A_ENST00000443581.1_Silent_p.I1200I	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1201					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGTGCTCCACGATGTGGTAGC	0.617000													9	16					0	0	1	0	0
PROKR1	10887	broad.mit.edu	37	2	68873164	68873164	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:68873164G>A	ENST00000303786.3	+	2	631	c.211G>A	c.(211-213)Ggc>Agc	p.G71S	PROKR1_ENST00000394342.2_Missense_Mutation_p.G71S			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	71						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GGCCCTGGTGGGCATCATGCT	0.517000													19	187					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66084128	66084128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66084128C>T	ENST00000311330.3	-	1	387	c.371G>A	c.(370-372)gGc>gAc	p.G124D	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	124	C-type lectin.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	CGGGCAGGGGCCTCCAGAGGC	0.711000													13	29					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103654	53103654	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:53103654G>A	ENST00000408890.4	+	1	306	c.290G>A	c.(289-291)tGg>tAg	p.W97*		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	97										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						TCCGAGGGCTGGAGGCGCCCT	0.711000													14	22					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730673	96730673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96730673C>T	ENST00000216629.6	+	3	1260	c.654C>T	c.(652-654)atC>atT	p.I218I	BDKRB1_ENST00000553356.1_Silent_p.I218I|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	218					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TGGCTGCGATCGTCTTCTTCA	0.582000													14	48					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48157768	48157768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48157768C>T	ENST00000418331.2	+	9	2145	c.1793C>T	c.(1792-1794)cCg>cTg	p.P598L		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	598	Fibronectin type-III 6.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GGCCTGATTCCGGGCACCTTA	0.512000													32	42					0	0	1	0	0
RABL2A	11159	broad.mit.edu	37	2	114398531	114398531	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:114398531C>T	ENST00000409875.1	+	7	660	c.358C>T	c.(358-360)Cgg>Tgg	p.R120W	RABL2A_ENST00000393167.3_Missense_Mutation_p.R120W|RABL2A_ENST00000393165.3_Missense_Mutation_p.R120W|RABL2A_ENST00000393166.3_Missense_Mutation_p.R120W|RABL2A_ENST00000409842.1_Intron|RABL2A_ENST00000478880.1_3'UTR|RABL2A_ENST00000376439.3_Intron			Q9UBK7	RBL2A_HUMAN	RAB, member of RAS oncogene family-like 2A	120					small GTPase mediated signal transduction		GTP binding|GTPase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|stomach(3)	9						TACAGAGCTTCGGGAGTTCAG	0.512000													22	55					0	0	1	0	0
CCDC116	164592	broad.mit.edu	37	22	21989023	21989023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21989023C>T	ENST00000292779.3	+	4	832	c.671C>T	c.(670-672)tCg>tTg	p.S224L		NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	224										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					CTGTGGGATTCGCTGGGTAGC	0.597000													93	227					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65464345	65464345	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:65464345C>T	ENST00000330909.8	-	4	678	c.679G>A	c.(679-681)Gat>Aat	p.D227N	MAGI1_ENST00000497477.2_Missense_Mutation_p.D227N|MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000402939.2_Missense_Mutation_p.D227N|MAGI1_ENST00000483466.1_Missense_Mutation_p.D227N	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	227	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TTTTGCATATCATTGTAGGAC	0.512000													31	123					0	0	1	0	0
KIAA1468	57614	broad.mit.edu	37	18	59947646	59947646	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59947646C>T	ENST00000398130.2	+	23	3253	c.3021C>T	c.(3019-3021)gcC>gcT	p.A1007A	KIAA1468_ENST00000256858.6_Intron	NM_020854.3	NP_065905.2	Q9P260	K1468_HUMAN	KIAA1468	1007							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				TTGCTCCGGCCCTTGTTACCT	0.438000													27	133					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233807177	233807177	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233807177C>T	ENST00000366621.3	+	3	1080	c.912C>T	c.(910-912)atC>atT	p.I304I	KCNK1_ENST00000472190.1_3'UTR|KCNK1_ENST00000366620.1_Silent_p.I188I	NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	304						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TCTCCTCGATCACAGACCAGG	0.488000													8	66					0	0	1	0	0
SYPL2	284612	broad.mit.edu	37	1	110018223	110018223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110018223C>T	ENST00000369872.3	+	3	366	c.150C>T	c.(148-150)ttC>ttT	p.F50F	SYPL2_ENST00000401021.3_Silent_p.F50F|SYPL2_ENST00000475497.1_3'UTR	NM_001040709.1	NP_001035799.1	Q5VXT5	SYPL2_HUMAN	synaptophysin-like 2	50	MARVEL.					integral to membrane|synaptic vesicle	transporter activity			breast(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		TTTTCGCCTTCGGGTCCTGTG	0.547000													13	64					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66479639	66479639	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:66479639G>A	ENST00000256447.4	-	3	1189	c.1032C>T	c.(1030-1032)ttC>ttT	p.F344F		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	344					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TAAGGGAGGGGAAATTGGCAG	0.433000													56	142					0	0	1	0	0
TDP1	55775	broad.mit.edu	37	14	90509483	90509483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90509483C>T	ENST00000335725.4	+	17	2073	c.1823C>T	c.(1822-1824)tCc>tTc	p.S608F	TDP1_ENST00000555880.1_Missense_Mutation_p.P572S|TDP1_ENST00000357382.3_Missense_Mutation_p.S369F|TDP1_ENST00000393454.2_Missense_Mutation_p.S608F|TDP1_ENST00000393452.3_3'UTR	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	608					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGGTGCCCTCCTGAGAATCT	0.423000								Repair of DNA-protein crosslinks					17	49					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52884373	52884373	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52884373C>T	ENST00000330722.6	-	5	1125	c.1057G>A	c.(1057-1059)Gag>Aag	p.E353K		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	353	Coil 2.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		TACCAGGACTCAGCCTCAGCC	0.577000													91	174					0	0	1	0	0
UGT1A7	54577	broad.mit.edu	37	2	234590866	234590866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234590866G>A	ENST00000373426.3	+	1	283	c.283G>A	c.(283-285)Gat>Aat	p.D95N	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A9_ENST00000354728.4_Intron	NM_019077.2	NP_061950.2														NS(1)|endometrium(6)|kidney(5)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|prostate(1)|skin(1)	33		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGTTTTTGCCGATGCTCGCTG	0.433000													61	142					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57406576	57406576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57406576C>T	ENST00000543257.1	-	10	1754	c.1188G>A	c.(1186-1188)ctG>ctA	p.L396L	C8B_ENST00000371237.4_Silent_p.L448L|C8B_ENST00000535057.1_Silent_p.L386L	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	448	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ACTCCTGCATCAGGTCCGCCG	0.572000													22	71					0	0	1	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899267	112899267	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112899267C>T	ENST00000374530.3	+	8	1623	c.1443C>T	c.(1441-1443)atC>atT	p.I481I	AKAP2_ENST00000259318.7_Silent_p.I250I|AKAP2_ENST00000434623.2_Silent_p.I339I|AKAP2_ENST00000374525.1_Silent_p.I339I|AKAP2_ENST00000510514.5_Silent_p.I481I|AKAP2_ENST00000555236.1_Silent_p.I481I|PALM2-AKAP2_ENST00000302798.7_Silent_p.I481I	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		250							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						AAAAAACCATCGAGGAGCAGC	0.537000													15	40					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24810379	24810379	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24810379C>T	ENST00000221169.5	-	0	2171							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		ttcttctcctcctcttcagct	0.413000													22	65					0	0	1	0	0
LRRN4	164312	broad.mit.edu	37	20	6022130	6022130	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6022130C>T	ENST00000378858.4	-	5	1985	c.1761G>A	c.(1759-1761)ggG>ggA	p.G587G		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	587	Fibronectin type-III.					integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						TCTCCGTCACCCCCTGCAGCC	0.711000													28	60					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115526413	115526413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115526413G>A	ENST00000361048.1	+	4	487	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	PLEKHS1_ENST00000369312.4_5'UTR|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.E48K	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		AAAGGCTGGGGAAAAGAGCTT	0.338000													42	80					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10615137	10615137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:10615137G>A	ENST00000547195.1	-	16	2304	c.1804C>T	c.(1804-1806)Cgc>Tgc	p.R602C	MRVI1_ENST00000531107.1_Missense_Mutation_p.R685C|MRVI1-AS1_ENST00000529979.1_RNA|MRVI1_ENST00000552103.1_Missense_Mutation_p.R602C|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000421747.1_Missense_Mutation_p.R684C|MRVI1_ENST00000558540.1_Missense_Mutation_p.R378C|MRVI1_ENST00000527509.2_Missense_Mutation_p.R602C|MRVI1_ENST00000545852.1_Missense_Mutation_p.R378C|MRVI1_ENST00000436272.1_Missense_Mutation_p.R666C|MRVI1-AS1_ENST00000525578.1_RNA|MRVI1-AS1_ENST00000529829.1_RNA|MRVI1_ENST00000541483.1_Missense_Mutation_p.R487C|MRVI1_ENST00000423302.2_Missense_Mutation_p.R693C|MRVI1_ENST00000424001.1_Missense_Mutation_p.R378C|MRVI1_ENST00000534266.2_Missense_Mutation_p.R378C	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	666					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		ACCCTCCGGCGAGGCATATTC	0.512000													13	40					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43246125	43246125	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43246125G>A	ENST00000255226.6	+	12	2314	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K	SLC14A2_ENST00000586448.1_Missense_Mutation_p.E500K|SLC14A2_ENST00000589658.1_5'UTR	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	500						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CGAACACCAGGAAAGACAAAA	0.507000											OREG0024946	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	86					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4834032	4834032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4834032C>T	ENST00000268231.8	-	5	675	c.412G>A	c.(412-414)Gag>Aag	p.E138K	SEPT12_ENST00000396693.5_Intron	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	138					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						AGGTACTGCTCGTATTGCTCG	0.632000													14	150					0	0	1	0	0
MDH1B	130752	broad.mit.edu	37	2	207620226	207620226	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207620226G>A	ENST00000374412.3	-	5	692	c.417C>T	c.(415-417)gcC>gcT	p.A139A	MDH1B_ENST00000454776.2_Silent_p.A139A|MDH1B_ENST00000449792.1_Silent_p.A41A|MDH1B_ENST00000392214.2_Intron	NM_001039845.1	NP_001034934.1	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	139					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(14)|ovary(4)|stomach(1)	34				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		CAGGAGCAGAGGCACTGATAA	0.398000													22	70					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70954982	70954982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70954982G>A	ENST00000393567.2	-	46	7447	c.7297C>T	c.(7297-7299)Cct>Tct	p.P2433S		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2433										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TGGACAAGAGGAAGCCCATGC	0.458000													31	126					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201358367	201358367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201358367G>A	ENST00000391967.2	-	2	404	c.103C>T	c.(103-105)Cgc>Tgc	p.R35C	LAD1_ENST00000367313.3_Missense_Mutation_p.R49C	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	35	Poly-Arg.					basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						CTCAGGTTGCGGTGCCGCCGC	0.657000													19	44					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62253103	62253103	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:62253103A>G	ENST00000474889.1	+	18	3052	c.2675A>G	c.(2674-2676)aAg>aGg	p.K892R	PTPRG_ENST00000295874.10_Missense_Mutation_p.K863R|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000495542.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	892	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		AGTAGGGTGAAGTTAAGACCT	0.333000													42	111					0	0	1	0	0
RGS5	8490	broad.mit.edu	37	1	163117238	163117238	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:163117238G>A	ENST00000313961.5	-	5	717	c.440C>T	c.(439-441)tCc>tTc	p.S147F	RGS5_ENST00000527988.1_Missense_Mutation_p.S39F|RGS5_ENST00000530507.1_Missense_Mutation_p.S151F|RGS5_ENST00000367903.3_Missense_Mutation_p.S167F	NM_001254749.1|NM_003617.3	NP_001241678.1|NP_003608.1	O15539	RGS5_HUMAN	regulator of G-protein signaling 5	147	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20			LUSC - Lung squamous cell carcinoma(543;0.187)			GCTGCTCAGGGAAGGTTCCAC	0.463000													30	82					0	0	1	0	0
GABRQ	55879	broad.mit.edu	37	X	151818293	151818293	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151818293C>T	ENST00000370306.2	+	6	719	c.699C>T	c.(697-699)ttC>ttT	p.F233F		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	233						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCTCAGTTCACTTTCCTGG	0.498000													36	50					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85446507	85446507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:85446507C>T	ENST00000369663.5	-	8	2057	c.1720G>A	c.(1720-1722)Gga>Aga	p.G574R	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	574					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AGGTGCACTCCTTCCACAGGG	0.517000													22	26					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27997849	27997849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27997849C>T	ENST00000441525.1	-	1	1717	c.1603G>A	c.(1603-1605)Gac>Aac	p.D535N		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	535										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						TTCAAGTTGTCTTCATCTCGC	0.483000													43	23					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50744591	50744591	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50744591C>T	ENST00000300589.2	+	4	874	c.769C>T	c.(769-771)Ctg>Ttg	p.L257L	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	257					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				AGAGAATGTCCTGGAGGTCTG	0.607000													6	33					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192545472	192545472	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:192545472G>A	ENST00000367459.3	+	2	261	c.195G>A	c.(193-195)atG>atA	p.M65I	RGS1_ENST00000469578.2_Missense_Mutation_p.M65I	NM_002922.3	NP_002913.3	Q08116	RGS1_HUMAN	regulator of G-protein signaling 1	65					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			kidney(8)|large_intestine(1)|lung(13)	22		Breast(1374;0.188)				AATCTGGAATGAAATCTTCCA	0.343000													24	49					0	0	1	0	0
HOMEZ	57594	broad.mit.edu	37	14	23746205	23746205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23746205G>A	ENST00000357460.5	-	2	396	c.232C>T	c.(232-234)Ccc>Tcc	p.P78S	HOMEZ_ENST00000561013.1_Missense_Mutation_p.P80S|HOMEZ_ENST00000431326.2_Missense_Mutation_p.P80S	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	78						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CTGGGATAGGGAAAGTAGCTG	0.537000													9	126					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588440	93588440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93588440C>T	ENST00000329082.7	-	4	1412	c.1141G>A	c.(1141-1143)Gac>Aac	p.D381N	RGMA_ENST00000543599.1_Missense_Mutation_p.D365N|RGMA_ENST00000557420.1_3'UTR|RGMA_ENST00000538818.1_Missense_Mutation_p.D272N|RGMA_ENST00000425933.2_Missense_Mutation_p.D365N|RGMA_ENST00000556658.1_Missense_Mutation_p.D272N|RGMA_ENST00000557301.1_Missense_Mutation_p.D389N|RGMA_ENST00000542321.2_Missense_Mutation_p.D365N	NM_020211.2	NP_064596.2	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	381					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GTGAGGAGGTCGAAGACGCAG	0.592000													3	22					0	0	1	0	0
ZNF248	57209	broad.mit.edu	37	10	38121119	38121119	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:38121119G>A	ENST00000395867.3	-	6	1714	c.1164C>T	c.(1162-1164)acC>acT	p.T388T	ZNF248_ENST00000357328.4_Silent_p.T388T|ZNF248_ENST00000494133.1_Intron|ZNF248_ENST00000374648.3_Intron	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						TCTCCCAGAAGGTTTTCCCAC	0.443000													32	140					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40368832	40368832	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40368832C>T	ENST00000221347.6	-	28	12523	c.12516G>A	c.(12514-12516)ggG>ggA	p.G4172G		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4172	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTGAAATCCGCCCGTCGGCCA	0.617000													38	225					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140221334	140221334	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140221334C>T	ENST00000531613.1	+	1	428	c.428C>T	c.(427-429)tCa>tTa	p.S143L	PCDHA8_ENST00000378123.3_Missense_Mutation_p.S143L|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTTTGTTTCAGAATCCAGA	0.517000													49	113					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28548732	28548732	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:28548732C>T	ENST00000401766.2	-	2	757	c.245G>A	c.(244-246)tGg>tAg	p.W82*	SLC6A4_ENST00000261707.3_Nonsense_Mutation_p.W82*			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	82					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CTTCTTGCCCCAGGTCTCCCG	0.567000													51	61					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7373425	7373425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7373425C>T	ENST00000502583.1	-	5	2191	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	CAGE1_ENST00000338150.4_Missense_Mutation_p.E543K|CAGE1_ENST00000512086.1_Missense_Mutation_p.E543K|CAGE1_ENST00000296742.7_Missense_Mutation_p.E407K|CAGE1_ENST00000379918.4_Missense_Mutation_p.E543K	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	543										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					TTTGCATTCTCATTTTTTACT	0.333000													4	45					0	0	1	0	0
RAB40AL	282808	broad.mit.edu	37	X	102193023	102193023	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:102193023C>T	ENST00000218249.5	+	1	824	c.777C>T	c.(775-777)atC>atT	p.I259I	LL0XNC01-237H1.3_ENST00000413528.1_RNA	NM_001031834.1	NP_001027004.1	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	259					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(3)	12						AAGTGAAGATCGTCTGCCCAC	0.537000													47	39					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123333775	123333775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123333775G>A	ENST00000296513.2	+	10	1245	c.1060G>A	c.(1060-1062)Gaa>Aaa	p.E354K	ADAD1_ENST00000388725.2_Missense_Mutation_p.E336K|ADAD1_ENST00000388724.2_Missense_Mutation_p.E343K	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	354	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TGAAGCCAATGAAGAACTCTG	0.358000													17	175					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38531036	38531036	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38531036G>A	ENST00000332509.3	-	6	1036	c.853C>T	c.(853-855)Cgt>Tgt	p.R285C	PLA2G6_ENST00000402064.1_Missense_Mutation_p.R285C|PLA2G6_ENST00000335539.3_Missense_Mutation_p.R285C	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	285					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	GCTCCGTAACGGGGGTCTTTG	0.657000													20	59					0	0	1	0	0
PHB	5245	broad.mit.edu	37	17	47482519	47482519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47482519G>A	ENST00000300408.3	-	7	726	c.654C>T	c.(652-654)tcC>tcT	p.S218S	RP11-81K2.1_ENST00000576461.1_Intron|PHB_ENST00000511832.1_Intron|RP11-1079K10.4_ENST00000506504.3_RNA	NM_002634.2	NP_002625.1	P35232	PHB_HUMAN	prohibitin	218					cellular response to interleukin-6|DNA replication|glucocorticoid receptor signaling pathway|histone deacetylation|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|progesterone receptor signaling pathway|regulation of apoptosis	integral to plasma membrane|mitochondrial inner membrane|nucleoplasm	histone deacetylase binding|transcription regulatory region DNA binding			endometrium(4)|large_intestine(2)|lung(4)	10	all_cancers(4;2.62e-14)|Breast(4;4.21e-29)|all_epithelial(4;6.9e-18)		Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)			CAGCTGCCTTGGAGTCGCCCT	0.567000													4	29					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129781995	129781995	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:129781995G>A	ENST00000358825.5	-	19	3210	c.2979C>T	c.(2977-2979)gcC>gcT	p.A993A	PRDM10_ENST00000528746.1_Intron|PRDM10_ENST00000423662.2_Intron|PRDM10_ENST00000360871.3_Silent_p.A989A|PRDM10_ENST00000304538.6_Intron|PRDM10_ENST00000526082.1_Silent_p.A907A	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	984	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CGGAGGACGGGGCCGAGGCGG	0.572000													37	117					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269998	150269998	+	Silent	SNP	G	G	A	rs77995447		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150269998G>A	ENST00000255945.2	+	3	1015	c.840G>A	c.(838-840)gaG>gaA	p.E280E	GIMAP4_ENST00000461940.1_Silent_p.E294E|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	280							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAAATGGAGAAGAAACTAG	0.443000													22	50					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13381784	13381784	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13381784G>A	ENST00000254508.5	-	24	3325	c.3243C>T	c.(3241-3243)ttC>ttT	p.F1081F	NUP210_ENST00000485755.1_Intron	NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1081					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GCATCAGCCTGAACGGGGGAA	0.577000													8	42					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125148802	125148802	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125148802G>A	ENST00000362012.2	+	9	1092	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K	PTGS1_ENST00000373698.5_Missense_Mutation_p.E254K|PTGS1_ENST00000540753.1_Missense_Mutation_p.E338K|AL162424.1_ENST00000600713.1_Intron|PTGS1_ENST00000223423.4_Missense_Mutation_p.E363K	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	363					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATTTGACCCAGAGCTGCTGTT	0.537000													40	142					0	0	1	0	0
PRKG1	5592	broad.mit.edu	37	10	54040554	54040554	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:54040554C>T	ENST00000373980.4	+	13	1826	c.1409C>T	c.(1408-1410)tCg>tTg	p.S470L	PRKG1-AS1_ENST00000426785.2_RNA|PRKG1-AS1_ENST00000452247.2_RNA|PRKG1_ENST00000401604.2_Missense_Mutation_p.S455L|PRKG1_ENST00000373975.2_Missense_Mutation_p.S173L|PRKG1_ENST00000373985.1_Missense_Mutation_p.S443L	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	455	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		CTCAGAGGTTCGTTTGAAGAT	0.343000													25	84					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71444949	71444949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:71444949C>T	ENST00000304743.2	+	6	2341	c.1895C>T	c.(1894-1896)tCc>tTc	p.S632F	PCNX_ENST00000238570.5_Missense_Mutation_p.S632F|PCNX_ENST00000439984.3_Missense_Mutation_p.S632F	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	632	Ser-rich.					integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ACTTCTCATTCCTGTCAGTCT	0.463000													19	88					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2940692	2940692	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:2940692G>A	ENST00000261596.4	-	5	847	c.609C>T	c.(607-609)tcC>tcT	p.S203S		NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	203					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CTTCTTTCAAGGAAGCATTTG	0.413000													14	38					0	0	1	0	0
SAMD3	154075	broad.mit.edu	37	6	130505248	130505248	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:130505248G>A	ENST00000532763.1	-	6	777	c.648_splice	c.e6+1	p.F216_splice	SAMD3_ENST00000324172.6_Splice_Site_p.F218_splice|SAMD3_ENST00000437477.2_Splice_Site_p.F218_splice|SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000439090.2_Splice_Site_p.F218_splice|SAMD3_ENST00000457563.2_Splice_Site_p.F242_splice|SAMD3_ENST00000368134.2_Splice_Site_p.F218_splice			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	218										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		GGTCACTTACGAAGCCACAGC	0.468000													10	13					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23816229	23816229	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:23816229C>T	ENST00000264867.2	-	8	997		c.e8-1		PPARGC1A_ENST00000509702.1_Splice_Site	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha						androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GGAGTTAGGCCTAAGGCAAAA	0.393000													17	39					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53295761	53295761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53295761G>A	ENST00000552551.1	-	3	852	c.420C>T	c.(418-420)ttC>ttT	p.F140F	KRT8_ENST00000293308.6_Silent_p.F140F|KRT8_ENST00000546897.1_Silent_p.F140F|KRT8_ENST00000552150.1_Silent_p.F168F			P05787	K2C8_HUMAN	keratin 8	140	Linker 1.|Rod.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTAGCTCTCGAACATGTTGT	0.572000													16	63					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53907746	53907746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:53907746C>T	ENST00000396328.1	-	15	2896	c.2657G>A	c.(2656-2658)aGa>aAa	p.R886K	WDR72_ENST00000559418.1_Missense_Mutation_p.R896K|WDR72_ENST00000360509.5_Missense_Mutation_p.R886K|WDR72_ENST00000557913.1_Missense_Mutation_p.R883K	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	886										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTCCAATCCTCTTGGAATTCC	0.313000													13	69					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2182194	2182194	+	Silent	SNP	C	C	T	rs1803766		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:2182194C>T	ENST00000382203.1	+	31	4622	c.4413C>T	c.(4411-4413)gtC>gtT	p.V1471V	SMARCA2_ENST00000302401.3_Silent_p.V159V|SMARCA2_ENST00000382185.1_Silent_p.V117V|SMARCA2_ENST00000382194.1_Silent_p.V1453V|SMARCA2_ENST00000382186.1_Silent_p.V135V|SMARCA2_ENST00000349721.2_Silent_p.V1471V|SMARCA2_ENST00000324954.5_Silent_p.V117V|SMARCA2_ENST00000357248.2_Silent_p.V1453V			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1471	Bromo.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AGAAGGATGTCATGCTTCTCT	0.443000													16	133					0	0	1	0	0
LOC344967	344967	broad.mit.edu	37	4	40045554	40045554	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40045554G>A	ENST00000381811.2	-	0	595					NR_027277.1																						TGGGCCACAGGAAGTGGGTGC	0.612000													4	10					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201029892	201029892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201029892G>A	ENST00000362061.3	-	26	3534	c.3308C>T	c.(3307-3309)cCc>cTc	p.P1103L	CACNA1S_ENST00000367338.3_Missense_Mutation_p.P1103L	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1103					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGGGTTTTTGGGAATGTAGCA	0.537000													18	277					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5489039	5489039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:5489039G>A	ENST00000341928.2	-	2	484	c.144C>T	c.(142-144)ttC>ttT	p.F48F	EPB41L3_ENST00000540638.2_Silent_p.F48F|EPB41L3_ENST00000400111.3_Silent_p.F48F|EPB41L3_ENST00000544123.1_Silent_p.F48F|EPB41L3_ENST00000342933.3_Silent_p.F48F	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	48					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						CAGCGGCGGCGAACTGCTCCA	0.721000													10	30					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389397	4389397	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4389397C>T	ENST00000408920.2	-	1	219	c.129G>A	c.(127-129)ggG>ggA	p.G43G		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCAGGCTGTTCCCAAGAAGGG	0.527000													11	29					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166172174	166172174	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166172174C>T	ENST00000375437.2	+	11	1867	c.1577C>T	c.(1576-1578)tCg>tTg	p.S526L	SCN2A_ENST00000375427.2_Missense_Mutation_p.S526L|SCN2A_ENST00000357398.3_Missense_Mutation_p.S526L|SCN2A_ENST00000283256.6_Missense_Mutation_p.S526L	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	526					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	GTCCGAAAATCGGAATCTGAA	0.373000													32	89					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585815	179585815	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179585815C>T	ENST00000589042.1	-	79	23155	c.22931G>A	c.(22930-22932)cGa>cAa	p.R7644Q	TTN_ENST00000342992.6_Missense_Mutation_p.R6400Q|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R7327Q	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7327	Ig-like 58.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGTCATTTCGGAACCATGA	0.393000													22	92					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128928849	128928849	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128928849C>T	ENST00000375990.3	+	28	3426	c.3023C>T	c.(3022-3024)cCt>cTt	p.P1008L	UGGT1_ENST00000259253.6_Missense_Mutation_p.P1032L			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	1032					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TCTGACATGCCTTTAAAAAGG	0.338000													13	40					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64056769	64056769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64056769C>T	ENST00000411458.1	+	9	1388	c.1360C>T	c.(1360-1362)Cgt>Tgt	p.R454C	GPR137_ENST00000539851.1_3'UTR|GPR137_ENST00000313074.3_Missense_Mutation_p.R396C|GPR137_ENST00000438980.2_3'UTR|GPR137_ENST00000377702.4_3'UTR	NM_001170726.1	NP_001164197.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	396						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						TCCTGGGGGTCGTGGCTACCC	0.667000													64	149					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152277022	152277022	+	Missense_Mutation	SNP	C	C	T	rs138147945	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152277022C>T	ENST00000368799.1	-	3	10375	c.10340G>A	c.(10339-10341)gGa>gAa	p.G3447E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3447	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTAGTGGGATCCCTGCCTTCC	0.607000									Ichthyosis				177	398					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	48098736	48098736	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:48098736G>A	ENST00000371741.4	-	1	448	c.282C>T	c.(280-282)tcC>tcT	p.S94S		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	94					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AGTTGAGGATGGAGGTGAAGG	0.597000													12	52					0	0	1	0	0
SLC12A4	6560	broad.mit.edu	37	16	67997414	67997414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67997414G>A	ENST00000316341.3	-	2	304	c.164C>T	c.(163-165)gCt>gTt	p.A55V	SLC12A4_ENST00000572037.1_Intron|SLC12A4_ENST00000422611.2_Intron|SLC12A4_ENST00000541864.2_Missense_Mutation_p.A24V|SLC12A4_ENST00000537830.2_Missense_Mutation_p.A49V|SLC12A4_ENST00000576616.1_Missense_Mutation_p.A55V|SLC12A4_ENST00000338335.3_Missense_Mutation_p.A55V|SLC12A4_ENST00000572010.1_5'UTR	NM_001145961.1|NM_005072.4	NP_001139433.1|NP_005063.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	55					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCTCTGGAAGCCTCCAAGGG	0.547000													5	74					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216595616	216595616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216595616G>A	ENST00000366943.2	-	2	449	c.63C>T	c.(61-63)atC>atT	p.I21I	USH2A_ENST00000307340.3_Silent_p.I21I|USH2A_ENST00000366942.3_Silent_p.I21I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	21					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AATAGGCAAAGATCAACATTT	0.428000										HNSCC(13;0.011)			27	72					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161318012	161318012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:161318012C>T	ENST00000428797.2	+	9	1167	c.812C>T	c.(811-813)tCc>tTc	p.S271F	GABRA1_ENST00000420560.1_Missense_Mutation_p.S271F|GABRA1_ENST00000444819.1_Missense_Mutation_p.S271F|GABRA1_ENST00000437025.2_Missense_Mutation_p.S271F|GABRA1_ENST00000023897.6_Missense_Mutation_p.S271F|GABRA1_ENST00000393943.4_Missense_Mutation_p.S271F	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	271					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TCACAAGTCTCCTTCTGGCTC	0.413000													20	80					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140258001	140258001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:140258001G>A	ENST00000275884.6	-	10	2318	c.1901C>T	c.(1900-1902)tCa>tTa	p.S634L	DENND2A_ENST00000537639.1_Missense_Mutation_p.S634L|DENND2A_ENST00000492720.1_Missense_Mutation_p.S634L|DENND2A_ENST00000496613.1_Missense_Mutation_p.S634L			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	634	UDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					TAAGACAAATGAGAATGTTTC	0.473000													18	47					0	0	1	0	0
NFS1	9054	broad.mit.edu	37	20	34278402	34278402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34278402G>A	ENST00000374092.4	-	5	564	c.494C>T	c.(493-495)tCa>tTa	p.S165L	NFS1_ENST00000541387.1_Intron|NFS1_ENST00000540053.1_5'UTR|NFS1_ENST00000397425.1_Missense_Mutation_p.S105L|NFS1_ENST00000374085.1_Missense_Mutation_p.S105L	NM_021100.4	NP_066923.3	Q9Y697	NFS1_HUMAN	NFS1 cysteine desulfurase	165					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	18	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	AGCTTCCAGTGAACGGCAGGA	0.512000													96	201					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130383928	130383928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130383928G>A	ENST00000358511.6	+	35	6615	c.6584G>A	c.(6583-6585)cGa>cAa	p.R2195Q	COL6A6_ENST00000453409.2_Missense_Mutation_p.R2195Q	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	2195	Nonhelical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CAGCCCCCACGACCATTCCGA	0.403000													11	24					0	0	1	0	0
LEMD1	93273	broad.mit.edu	37	1	205388426	205388426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205388426G>A	ENST00000367153.4	-	3	239	c.137C>T	c.(136-138)cCc>cTc	p.P46L	LEMD1_ENST00000367154.1_Missense_Mutation_p.P46L|LEMD1_ENST00000367151.2_Intron|LEMD1_ENST00000476884.1_Intron|LEMD1_ENST00000367149.3_Intron|LEMD1_ENST00000391936.2_Missense_Mutation_p.P46L|LEMD1_ENST00000367152.1_Intron	NM_001199050.1	NP_001185979.1	Q68G75	LEMD1_HUMAN	LEM domain containing 1	46						integral to membrane|nuclear envelope				breast(1)|lung(2)	3	Breast(84;0.247)		BRCA - Breast invasive adenocarcinoma(75;0.0938)			TGGTGCACAGGGAGGTGAGAC	0.448000													49	117					0	0	1	0	0
NTSR2	23620	broad.mit.edu	37	2	11809800	11809800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11809800G>A	ENST00000306928.5	-	1	490	c.456C>T	c.(454-456)acC>acT	p.T152T		NM_012344.3	NP_036476.1	O95665	NTR2_HUMAN	neurotensin receptor 2	152					sensory perception	integral to plasma membrane				breast(1)|large_intestine(7)|lung(7)|prostate(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	CCAGCCACCGGGTCCGGCGTG	0.741000													4	6					0	0	1	0	0
PBLD	64081	broad.mit.edu	37	10	70051922	70051922	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70051922G>A	ENST00000358769.2	-	5	559	c.357C>T	c.(355-357)atC>atT	p.I119I	PBLD_ENST00000495025.1_5'UTR|PBLD_ENST00000309049.4_Silent_p.I119I|PBLD_ENST00000432941.1_Silent_p.I119I|PBLD_ENST00000336578.1_Silent_p.I86I|PBLD_ENST00000277795.4_Silent_p.I86I	NM_022129.3	NP_071412.2	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing	119					biosynthetic process		isomerase activity	p.I119I(2)		endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						AGTCCAGGACGATGCCATCCT	0.468000													21	44					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106675690	106675690	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106675690G>A	ENST00000369701.3	+	3	1022	c.795_splice	c.e3+1	p.K265_splice		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	265						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACAAAAGGAAGGTAAGAGACT	0.453000													20	63					0	0	1	0	0
IL33	90865	broad.mit.edu	37	9	6254512	6254512	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:6254512G>A	ENST00000381434.3	+	6	584	c.571G>A	c.(571-573)Gac>Aac	p.D191N	IL33_ENST00000456383.2_Missense_Mutation_p.D149N|IL33_ENST00000417746.2_Missense_Mutation_p.D65N	NM_033439.3	NP_254274.1	O95760	IL33_HUMAN	interleukin 33	191					positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity			breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|stomach(1)|urinary_tract(1)	16		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)		TCCTACAAAAGACTTCTGGTT	0.328000													6	41					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873421	91873421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:91873421C>T	ENST00000373094.1	+	7	4371	c.3526C>T	c.(3526-3528)Cca>Tca	p.P1176S	PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000361655.2_Missense_Mutation_p.P1158S|PCDH11X_ENST00000373097.1_Missense_Mutation_p.P1166S|PCDH11X_ENST00000373088.1_Missense_Mutation_p.P1139S|PCDH11X_ENST00000406881.1_Missense_Mutation_p.P1168S|PCDH11X_ENST00000298274.8_Missense_Mutation_p.P1139S	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1176					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCACAGCCCACCACTGTCACA	0.567000													40	25					0	0	1	0	0
STC1	6781	broad.mit.edu	37	8	23702404	23702404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:23702404C>T	ENST00000290271.2	-	4	906	c.623G>A	c.(622-624)cGa>cAa	p.R208Q	STC1_ENST00000524323.1_Missense_Mutation_p.R139Q	NM_003155.2	NP_003146.1	P52823	STC1_HUMAN	stanniocalcin 1	208					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GAAGTCAGCTCGTGGGTGTGT	0.557000													17	77					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171173052	171173052	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171173052G>A	ENST00000441535.1	+	6	793	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K	FMO2_ENST00000209929.7_Missense_Mutation_p.E226K|RP1-127D3.4_ENST00000445909.1_RNA|FMO2_ENST00000529935.1_3'UTR|RP1-45C12.1_ENST00000455124.1_RNA|RP1-127D3.4_ENST00000445290.1_RNA|RP1-127D3.4_ENST00000422841.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	226					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCGTATCTCTGAAGATGGCTA	0.468000													17	57					0	0	1	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74883533	74883533	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74883533C>T	ENST00000289575.5	+	7	1286	c.891C>T	c.(889-891)ttC>ttT	p.F297F	SLCO2B1_ENST00000428359.2_Silent_p.F275F|SLCO2B1_ENST00000454962.2_Silent_p.F70F|SLCO2B1_ENST00000341411.4_Silent_p.F70F|SLCO2B1_ENST00000526660.1_3'UTR|SLCO2B1_ENST00000531756.1_Silent_p.F42F|SLCO2B1_ENST00000532236.1_Silent_p.F181F|SLCO2B1_ENST00000525650.1_Silent_p.F153F	NM_007256.4	NP_009187.1	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family, member 2B1	297					sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(2)|endometrium(1)|large_intestine(7)|lung(20)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	39					Ergoloid mesylate(DB01049)	ACTTCTTCTTCCCCAAGGAAA	0.577000													39	78					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58302916	58302916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:58302916C>T	ENST00000249750.4	-	4	1191	c.424G>A	c.(424-426)Ggc>Agc	p.G142S	ALDH1A2_ENST00000347587.3_Missense_Mutation_p.G142S|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.G46S|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.G113S|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.G121S	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	142					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTGATGACGCCCTGCAAATCC	0.433000													23	52					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6943310	6943310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6943310G>A	ENST00000389658.3	-	62	9029	c.8936C>T	c.(8935-8937)aCt>aTt	p.T2979I		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2979	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCTTGAAGAGTGTGCCATTT	0.493000													37	126					0	0	1	0	0
SCIN	85477	broad.mit.edu	37	7	12683868	12683868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:12683868G>A	ENST00000297029.5	+	12	1788	c.1687G>A	c.(1687-1689)Gag>Aag	p.E563K	SCIN_ENST00000445618.2_Missense_Mutation_p.E316K|SCIN_ENST00000519209.1_Missense_Mutation_p.E316K	NM_001112706.2	NP_001106177.1	Q9Y6U3	ADSV_HUMAN	scinderin	563	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	17				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CCAGGAGGAGGAGAAAGGAGC	0.473000													5	13					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158974450	158974450	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158974450G>A	ENST00000605860.1	+	7	671	c.625_splice	c.e7+1	p.G209_splice	UPP2_ENST00000409859.4_Splice_Site_p.G209_splice|UPP2_ENST00000005756.4_Splice_Site_p.G152_splice|UPP2_ENST00000460456.1_Intron			O95045	UPP2_HUMAN	uridine phosphorylase 2	152					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						AGGGGGAATAGGTGAGACGGA	0.433000													29	95					0	0	1	0	0
DNAJC21	134218	broad.mit.edu	37	5	34945064	34945064	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:34945064C>T	ENST00000382021.2	+	8	1303	c.1076C>T	c.(1075-1077)cCt>cTt	p.P359L	DNAJC21_ENST00000303525.7_Missense_Mutation_p.P359L|DNAJC21_ENST00000342382.4_Missense_Mutation_p.P359L	NM_194283.3	NP_919259.3	Q5F1R6	DJC21_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 21	359	Glu-rich.				protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			TTTTCAAGACCTCAAATTGAT	0.358000													41	115					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35831879	35831879	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35831879C>T	ENST00000085219.5	+	7	1411	c.1345C>T	c.(1345-1347)Ccc>Tcc	p.P449S	CD22_ENST00000419549.2_Missense_Mutation_p.P277S|CD22_ENST00000341773.6_Missense_Mutation_p.P272S|CD22_ENST00000536635.2_Missense_Mutation_p.P361S|CD22_ENST00000270311.6_Missense_Mutation_p.P329S|CD22_ENST00000544992.2_Missense_Mutation_p.P449S|CD22_ENST00000594250.1_Missense_Mutation_p.P272S	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	449	Ig-like C2-type 4.				cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TTCCAGTAACCCCAGTGTTAC	0.522000													19	53					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98547864	98547864	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:98547864C>T	ENST00000359863.4	+	37	5501	c.5292C>T	c.(5290-5292)ttC>ttT	p.F1764F	TRRAP_ENST00000355540.3_Silent_p.F1746F|TRRAP_ENST00000446306.3_Silent_p.F1745F	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1764					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ACCCCAACTTCGGAGATGAAT	0.418000													42	85					0	0	1	0	0
PTGIR	5739	broad.mit.edu	37	19	47127184	47127184	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47127184G>A	ENST00000291294.2	-	2	432	c.299C>T	c.(298-300)aCc>aTc	p.T100I	PTGIR_ENST00000598865.1_Intron|PTGIR_ENST00000594275.1_Intron|PTGIR_ENST00000597185.1_Intron|PTGIR_ENST00000596260.1_Missense_Mutation_p.T100I	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	100					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GCCGAAGAAGGTCATGGCGAA	0.701000													4	11					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50480161	50480161	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50480161G>A	ENST00000266182.6	-	7	718	c.719C>T	c.(718-720)gCc>gTc	p.A240V	TTLL8_ENST00000440475.1_Missense_Mutation_p.A240V					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CCCCAGGTAGGCCTGGCACAC	0.612000													7	15					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16126970	16126970	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16126970C>T	ENST00000399408.2	+	6	795	c.620C>T	c.(619-621)cCc>cTc	p.P207L	ABCC1_ENST00000351154.5_Missense_Mutation_p.P207L|ABCC1_ENST00000346370.5_Missense_Mutation_p.P207L|ABCC1_ENST00000349029.5_Missense_Mutation_p.P207L|ABCC1_ENST00000345148.5_Missense_Mutation_p.P207L|ABCC1_ENST00000399410.3_Missense_Mutation_p.P207L			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	207					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CACTAGAATCCCTGCCCAGAG	0.547000													15	67					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53544456	53544456	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53544456C>T	ENST00000371500.3	+	10	1702	c.1361C>T	c.(1360-1362)gCc>gTc	p.A454V	PODN_ENST00000395871.2_Missense_Mutation_p.A331V|RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000312553.5_Missense_Mutation_p.A473V	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	425					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CACCGCGACGCCTTCCGCAAG	0.637000													38	81					0	0	1	0	0
TCEAL2	140597	broad.mit.edu	37	X	101381827	101381827	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:101381827G>A	ENST00000372780.1	+	3	244	c.25G>A	c.(25-27)Gaa>Aaa	p.E9K	TCEAL2_ENST00000329035.2_Missense_Mutation_p.E9K|TCEAL2_ENST00000476749.1_3'UTR	NM_080390.3	NP_525129.1	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						CAATGAAAATGAAGGAATGCC	0.463000													25	18					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55839150	55839150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:55839150G>A	ENST00000302000.6	-	3	425	c.331C>T	c.(331-333)Ccc>Tcc	p.P111S	PYGO1_ENST00000563719.1_Missense_Mutation_p.P111S	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	111	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		ATTCTTGGGGGAACGTGAGGT	0.473000													14	133					0	0	1	0	0
ESYT2	57488	broad.mit.edu	37	7	158536344	158536344	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:158536344G>A	ENST00000251527.5	-	16	1816	c.1751C>T	c.(1750-1752)tCc>tTc	p.S584F	ESYT2_ENST00000435514.2_Missense_Mutation_p.S19F	NM_020728.2	NP_065779.1	A0FGR8	ESYT2_HUMAN	extended synaptotagmin-like protein 2	612	C2 2.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(16)|prostate(2)	32						GTTCCCCAGGGAACACTGGTG	0.557000													13	38					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37271804	37271804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:37271804C>T	ENST00000373091.3	-	14	2231	c.2215G>A	c.(2215-2217)Gag>Aag	p.E739K	GRIK3_ENST00000373093.4_Missense_Mutation_p.E739K	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	739					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GTGGTGGACTCCATGAGCAGC	0.622000													23	88					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51729288	51729288	+	Silent	SNP	C	C	T	rs141510568	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51729288C>T	ENST00000436584.2	+	2	322	c.267C>T	c.(265-267)ttC>ttT	p.F89F	CD33_ENST00000262262.4_Silent_p.F216F|CD33_ENST00000421133.2_Silent_p.F89F|CD33_ENST00000391796.3_Silent_p.F216F			P20138	CD33_HUMAN	CD33 molecule	216	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AGGTGAAGTTCGCTGGAGCTG	0.627000													16	37					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12978676	12978676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12978676C>T	ENST00000251472.4	+	20	2490	c.2451C>T	c.(2449-2451)gcC>gcT	p.A817A		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	817					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						AGGATGAGGCCCGGCTGCGCA	0.731000													3	18					0	0	1	0	0
SPPL2B	56928	broad.mit.edu	37	19	2352957	2352957	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2352957C>T	ENST00000452401.2	+	0	1669				AC005258.3_ENST00000590001.1_RNA			Q8TCT7	PSL1_HUMAN	signal peptide peptidase like 2B							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCTACCTCCATCTCCGTGG	0.682000													12	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593736	179593736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179593736C>T	ENST00000589042.1	-	65	19253	c.19029G>A	c.(19027-19029)gtG>gtA	p.V6343V	TTN_ENST00000342992.6_Silent_p.V5099V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Silent_p.V6026V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6026	Ig-like 44.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACACTGTCCACAAATGAAA	0.423000													5	25					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067485	190067485	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190067485G>A	ENST00000367462.3	-	8	2195	c.1964C>T	c.(1963-1965)tCc>tTc	p.S655F	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.S553F	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		655						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CAGGTTCCGGGAAGGGTCAAT	0.443000													42	131					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93637034	93637034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:93637034G>A	ENST00000375754.4	+	9	1232	c.1084G>A	c.(1084-1086)Gag>Aag	p.E362K	SYK_ENST00000375751.4_Missense_Mutation_p.E339K|SYK_ENST00000375747.1_Missense_Mutation_p.E339K|SYK_ENST00000375746.1_Missense_Mutation_p.E362K	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	362	Linker.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						CAGGCCCAAGGAGGTTTACCT	0.527000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								45	210					0	0	1	0	0
WDR7	23335	broad.mit.edu	37	18	54363639	54363639	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:54363639C>T	ENST00000254442.3	+	12	1735	c.1524C>T	c.(1522-1524)ttC>ttT	p.F508F	WDR7_ENST00000589935.1_Intron|WDR7_ENST00000357574.3_Silent_p.F508F	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	508										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		AACATATCTTCTGTGTTCATG	0.363000													33	103					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57528795	57528795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57528795G>A	ENST00000420713.1	+	4	740	c.628G>A	c.(628-630)Gag>Aag	p.E210K		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TCATACTAGGGAGAAGTCTTA	0.358000													5	25					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802863	185802863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:185802863C>T	ENST00000302277.6	+	4	3334	c.2740C>T	c.(2740-2742)Ccc>Tcc	p.P914S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	914						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTCCAATGATCCCACCACATC	0.398000													22	75					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097768	167097768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167097768G>A	ENST00000361200.2	+	6	3566	c.3400G>A	c.(3400-3402)Gat>Aat	p.D1134N	DUSP27_ENST00000271385.5_Missense_Mutation_p.D1134N|DUSP27_ENST00000443333.1_Missense_Mutation_p.D1134N|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1134					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGAAATGGACGATGAAGCCAT	0.522000													16	40					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92826581	92826581	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92826581C>T	ENST00000394468.2	-	7	1251	c.1174G>A	c.(1174-1176)Gaa>Aaa	p.E392K	HEPACAM2_ENST00000492616.1_5'UTR|HEPACAM2_ENST00000440868.1_Silent_p.Q371Q|HEPACAM2_ENST00000453812.2_Missense_Mutation_p.E415K|HEPACAM2_ENST00000341723.4_Missense_Mutation_p.E380K	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	392						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						TTCCTGTATTCTGTTTCTGGC	0.303000													22	52					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136575346	136575346	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136575346C>T	ENST00000264162.2	-	6	1282	c.1272G>A	c.(1270-1272)gcG>gcA	p.A424A		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	424	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCTCCAGCGTCGCTTGGCCCT	0.632000													30	93					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150656705	150656705	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150656705G>A	ENST00000392968.2	-	1	1259	c.139C>T	c.(139-141)Cat>Tat	p.H47Y	KCNH2_ENST00000430723.3_Missense_Mutation_p.H143Y|KCNH2_ENST00000262186.5_Missense_Mutation_p.H143Y			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	143	PAS.		G -> V (in LQT2).		blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TTGGTGTCATGAGCCGGGGAC	0.592000													25	65					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79440571	79440571	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79440571C>T	ENST00000264895.6	+	67	10916	c.10476C>T	c.(10474-10476)gcC>gcT	p.A3492A		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3487					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GGGGCTGGGCCTCCTTGGAGC	0.527000													68	172					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97620289	97620289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97620289G>A	ENST00000371203.5	+	7	1311	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	ENTPD1_ENST00000543964.1_Missense_Mutation_p.E272K|ENTPD1_ENST00000539125.1_Missense_Mutation_p.E242K|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000371207.3_Missense_Mutation_p.E392K|ENTPD1_ENST00000453258.2_Missense_Mutation_p.E387K|ENTPD1_ENST00000371205.4_Missense_Mutation_p.E380K|RP11-429G19.3_ENST00000433113.1_RNA	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	380					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		AGTCTCTCAGGAAAAGGTGAC	0.433000													14	34					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107330682	107330682	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107330682G>A	ENST00000265715.3	+	10	1487	c.1263_splice	c.e10+1	p.Q421_splice		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	421			Q -> R (in Pendred syndrome/deafness individuals).		regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GAAAGACACAGGTAGGAACAA	0.507000									Pendred syndrome				33	71					0	0	1	0	0
LHX1	3975	broad.mit.edu	37	17	35297980	35297980	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:35297980G>A	ENST00000254457.5	+	3	1882	c.471G>A	c.(469-471)gaG>gaA	p.E157E	RP11-445F12.2_ENST00000607336.1_RNA	NM_005568.3	NP_005559.2	P48742	LHX1_HUMAN	LIM homeobox 1	157					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Breast(25;0.00607)				AGGACTCGGAGAGCGCCAACG	0.632000													19	34					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85974125	85974125	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85974125G>A	ENST00000372117.3	+	17	2431	c.2328G>A	c.(2326-2328)gaG>gaA	p.E776E	CDHR1_ENST00000440770.2_Silent_p.E480E|CDHR1_ENST00000332904.3_Intron	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	776	Pro-rich.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						CTCCCAATGAGAACTGTAACA	0.612000													46	103					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70904966	70904966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70904966G>A	ENST00000264436.3	-	12	1871	c.1427C>T	c.(1426-1428)cCg>cTg	p.P476L	ADD2_ENST00000407644.2_Missense_Mutation_p.P476L|ADD2_ENST00000430656.1_Missense_Mutation_p.P492L|ADD2_ENST00000355733.3_Missense_Mutation_p.P476L|ADD2_ENST00000413157.2_Missense_Mutation_p.P476L	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	476					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						GATGCGAATCGGCATGCCACT	0.532000													8	81					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232551301	232551301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:232551301G>A	ENST00000366630.1	-	18	5059	c.4701C>T	c.(4699-4701)ctC>ctT	p.L1567L	SIPA1L2_ENST00000262861.4_Silent_p.L1567L|SIPA1L2_ENST00000308942.4_Silent_p.L641L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1567					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CTGTGTCCGGGAGGGGCATCA	0.542000													39	123					0	0	1	0	0
ZNF200	7752	broad.mit.edu	37	16	3274282	3274282	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3274282G>A	ENST00000431561.3	-	5	1410	c.798C>T	c.(796-798)taC>taT	p.Y266Y	ZNF200_ENST00000396868.3_Silent_p.Y265Y|AJ003147.9_ENST00000576468.1_RNA|ZNF200_ENST00000396871.4_Silent_p.Y265Y|ZNF200_ENST00000396870.4_Silent_p.Y265Y|ZNF200_ENST00000414144.2_Silent_p.Y266Y|ZNF200_ENST00000575948.1_Silent_p.Y265Y	NM_001145447.1|NM_003454.3	NP_001138919.1|NP_003445.2	P98182	ZN200_HUMAN	zinc finger protein 200	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	17						GGGAAATGAGGTAAGAACTTT	0.408000													30	49					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53157753	53157753	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53157753G>A	ENST00000296292.3	-	3	314	c.253C>T	c.(253-255)Ctg>Ttg	p.L85L	RFT1_ENST00000394738.3_Intron	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	85					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		AGCCACAGCAGGTTGAGGGTC	0.552000													25	49					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62547779	62547779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:62547779G>A	ENST00000430451.2	+	4	1418	c.1221G>A	c.(1219-1221)caG>caA	p.Q407Q	RP11-355I22.5_ENST00000553990.1_lincRNA|SYT16_ENST00000446982.2_3'UTR	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	407	C2 1.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		CGAACATACAGAGAGGGCCCA	0.592000													8	26					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14306775	14306775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:14306775C>T	ENST00000378053.3	-	2	1634	c.1378G>A	c.(1378-1380)Gaa>Aaa	p.E460K	MACROD2_ENST00000217246.4_Intron|FLRT3_ENST00000341420.4_Missense_Mutation_p.E460K|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	460	Fibronectin type-III.		E -> D (in dbSNP:rs35253731).		cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TCACTGCGTTCCCCTGTTACA	0.463000													33	84					0	0	1	0	0
SDF2L1	23753	broad.mit.edu	37	22	21998344	21998344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21998344C>T	ENST00000248958.4	+	3	622	c.546C>T	c.(544-546)atC>atT	p.I182I		NM_022044.2	NP_071327.2	Q9HCN8	SDF2L_HUMAN	stromal cell-derived factor 2-like 1	182	MIR 3.					endoplasmic reticulum lumen|membrane				prostate(1)	1	Colorectal(54;0.105)					GAAGCCCCATCCGTGGGCAGC	0.602000											OREG0026342	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	31					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43251400	43251400	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43251400G>A	ENST00000259750.4	+	14	3005	c.2922G>A	c.(2920-2922)ggG>ggA	p.G974G		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	974						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TGGAGGAGGGGGCCCGAGCGC	0.687000													33	44					0	0	1	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64640081	64640081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:64640081C>T	ENST00000498707.1	-	8	1606	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	ADAMTS9_ENST00000459780.1_Missense_Mutation_p.E422K|ADAMTS9_ENST00000295903.4_Missense_Mutation_p.E394K	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	422	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CCACTATCTTCACTAATAGAA	0.398000													26	178					0	0	1	0	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959603	45959603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45959603G>A	ENST00000400375.1	-	1	475	c.431C>T	c.(430-432)cCt>cTt	p.P144L	TSPEAR_ENST00000323084.4_Intron|TSPEAR_ENST00000397916.1_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	144	24 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						GCAGCAAACAGGCACACAGCA	0.582000													40	144					0	0	1	0	0
HPCA	3208	broad.mit.edu	37	1	33359166	33359166	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33359166G>A	ENST00000373467.3	+	3	522	c.420G>A	c.(418-420)gaG>gaA	p.E140E	HPCA_ENST00000480118.1_3'UTR	NM_002143.2	NP_002134.2	P84074	HPCA_HUMAN	hippocalcin	140							actin binding|calcium ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				AGATGCCGGAGGACGAGTCGA	0.647000													9	50					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45860744	45860744	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45860744C>T	ENST00000397928.1	+	31	4787	c.4342C>T	c.(4342-4344)Cac>Tac	p.H1448Y	TRPM2_ENST00000397932.2_Missense_Mutation_p.H1498Y|TRPM2_ENST00000300482.5_Missense_Mutation_p.H1448Y|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.H1394Y	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1448	Nudix hydrolase.					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CGTCAGCGTCCACTTCCAGGA	0.622000													46	95					0	0	1	0	0
FBXO28	23219	broad.mit.edu	37	1	224345107	224345107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:224345107C>T	ENST00000366862.5	+	5	809	c.766C>T	c.(766-768)Cct>Tct	p.P256S	FBXO28_ENST00000424254.2_3'UTR	NM_015176.3	NP_055991.1	Q9NVF7	FBX28_HUMAN	F-box protein 28	256										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(2)|skin(1)	10	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		CAAGCAAAATCCTTCAAGACA	0.458000													26	140					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46288297	46288297	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:46288297G>A	ENST00000378966.3	+	2	1445	c.1029G>A	c.(1027-1029)gaG>gaA	p.E343E	SPERT_ENST00000310521.1_Silent_p.E379E			Q8NA61	SPERT_HUMAN	spermatid associated	379						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		TGCAGGAGGAGAACAGGACCC	0.657000													4	15					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155485641	155485641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155485641G>A	ENST00000461783.3	+	10	3394	c.2121G>A	c.(2119-2121)ccG>ccA	p.P707P	TIAM2_ENST00000456144.1_Silent_p.P707P|TIAM2_ENST00000456877.2_Silent_p.P19P|TIAM2_ENST00000318981.5_Silent_p.P707P|TIAM2_ENST00000360366.4_Silent_p.P707P|TIAM2_ENST00000529824.2_Silent_p.P707P|TIAM2_ENST00000528391.2_Silent_p.P19P|TIAM2_ENST00000367174.2_Silent_p.P59P			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	707					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GGGAGTTACCGAACCCAAAGA	0.542000													62	88					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13922221	13922221	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13922221C>T	ENST00000265104.4	-	5	759	c.655G>A	c.(655-657)Gag>Aag	p.E219K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	219	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CTCACCTTCTCCTTCAGACTC	0.488000									Kartagener syndrome				11	25					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64668681	64668681	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:64668681G>A	ENST00000543942.2	-	11	2210	c.1584_splice	c.e11+1	p.I528_splice	C12orf56_ENST00000333722.5_Splice_Site_p.I368_splice|RPS11P6_ENST00000535684.1_RNA|C12orf56_ENST00000536975.1_5'UTR	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	531										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		AGATACTTACGATGGGAGGAC	0.373000													24	61					0	0	1	0	0
LAPTM5	7805	broad.mit.edu	37	1	31206707	31206707	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:31206707C>T	ENST00000294507.3	-	8	831	c.757G>A	c.(757-759)Ggc>Agc	p.G253S		NM_006762.2	NP_006753.1	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	253	Pro-rich.				transport	integral to plasma membrane|lysosomal membrane				large_intestine(2)|lung(7)|skin(1)	10		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		GGTGCTGGGCCCCCCTCTGGG	0.602000													10	29					0	0	1	0	0
LSAMP	4045	broad.mit.edu	37	3	115805287	115805287	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:115805287G>A	ENST00000490035.1	-	2	771	c.272C>T	c.(271-273)tCt>tTt	p.S91F	LSAMP_ENST00000539563.1_Missense_Mutation_p.S88F	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	91	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GTATTCCAGAGAATGGCGTTT	0.507000													17	72					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12979903	12979903	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12979903C>T	ENST00000251472.4	+	22	2836	c.2797C>T	c.(2797-2799)Ctt>Ttt	p.L933F		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	933					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						AAGTTCACCCCTTGCTAGTCC	0.562000													23	72					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103191703	103191703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103191703G>A	ENST00000424685.2	-	41	6272	c.6113C>T	c.(6112-6114)cCa>cTa	p.P2038L	RELN_ENST00000343529.5_Missense_Mutation_p.P2038L|RELN_ENST00000428762.1_Missense_Mutation_p.P2038L			P78509	RELN_HUMAN	reelin	2038					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGTCTCACTGGATCCGCGGA	0.502000													18	48					0	0	1	0	0
KLK9	284366	broad.mit.edu	37	19	51507037	51507037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51507037G>A	ENST00000376832.4	-	4	559	c.526C>T	c.(526-528)Cac>Tac	p.H176Y	KLK9_ENST00000594211.1_Missense_Mutation_p.H176Y|CTB-147C22.9_ENST00000594512.1_RNA|KLK9_ENST00000250366.6_Missense_Mutation_p.H176Y	NM_012315.1	NP_036447.1	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9	176	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		TATGCCCAGTGACAGAGTTTG	0.567000													28	44					0	0	1	0	0
LYZL1	84569	broad.mit.edu	37	10	29580895	29580895	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:29580895G>A	ENST00000375500.3	+	2	294	c.237G>A	c.(235-237)agG>agA	p.R79R		NM_032517.4	NP_115906.3	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	33					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)|cervix(2)|large_intestine(2)|lung(5)|skin(1)	11		Breast(68;0.203)				TATTCTCGAGGGCTGGCCTGG	0.522000													26	23					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57415241	57415241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57415241C>T	ENST00000543257.1	-	7	1261	c.695G>A	c.(694-696)cGa>cAa	p.R232Q	C8B_ENST00000371237.4_Missense_Mutation_p.R284Q|C8B_ENST00000535057.1_Missense_Mutation_p.R222Q	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	284	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ATGAGAGAATCGTTTGGTTCT	0.353000													29	40					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56098199	56098199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:56098199G>A	ENST00000394555.2	-	9	1495	c.1060C>T	c.(1060-1062)Cat>Tat	p.H354Y	EFEMP1_ENST00000394554.1_Missense_Mutation_p.H354Y|EFEMP1_ENST00000355426.3_Missense_Mutation_p.H354Y|EFEMP1_ENST00000424836.2_Missense_Mutation_p.H216Y	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	354	EGF-like 6; calcium-binding (Potential).|Mediates interaction with TIMP3.				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AAGCCGCCATGATAATTCCAA	0.378000													21	65					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147027949	147027949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147027949C>T	ENST00000265272.5	-	5	1393	c.926G>A	c.(925-927)cGa>cAa	p.R309Q	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.R267Q|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.R309Q	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	309						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTTCATTTCGTTCATCTCC	0.303000													36	98					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81706230	81706230	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81706230C>T	ENST00000372292.3	-	2	226	c.186G>A	c.(184-186)gaG>gaA	p.E62E		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	62	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			GGTCCCCCTTCTCGCCCCGAG	0.602000													24	47					0	0	1	0	0
LRRC47	57470	broad.mit.edu	37	1	3703511	3703511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3703511G>A	ENST00000378251.1	-	2	1006	c.979C>T	c.(979-981)Ccc>Tcc	p.P327S		NM_020710.2	NP_065761.1	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	327					translation		phenylalanine-tRNA ligase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		CGGACCTCGGGGCTCACTCTG	0.647000													4	12					0	0	1	0	0
GMPS	8833	broad.mit.edu	37	3	155643132	155643132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155643132C>T	ENST00000496455.1	+	12	1872	c.1537C>T	c.(1537-1539)Cca>Tca	p.P513S	GMPS_ENST00000295920.7_Missense_Mutation_p.P414S	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase	513					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTTCTTGCTGCCAATTAAAAC	0.403000			T	MLL	AML								20	21					0	0	1	0	0
CECR5	27440	broad.mit.edu	37	22	17630511	17630511	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17630511G>A	ENST00000336737.4	-	2	276	c.251C>T	c.(250-252)cCc>cTc	p.P84L	CECR5_ENST00000399852.3_Intron|CECR5_ENST00000155674.5_Missense_Mutation_p.P54L|CECR5_ENST00000480451.1_5'UTR	NM_033070.2	NP_149061.1	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	84							hydrolase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(10)|pancreas(1)|prostate(1)	21		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				AAAAACCACGGGCACCCGCAG	0.587000													63	121					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64408417	64408417	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:64408417T>C	ENST00000262043.3	+	8	3244	c.2904T>C	c.(2902-2904)tcT>tcC	p.S968S	PHF3_ENST00000393387.1_Silent_p.S968S			Q92576	PHF3_HUMAN	PHD finger protein 3	968	TFIIS central.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding	p.R971fs*6(1)		breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGCTTTTCTCTTTTTTTCGGG	0.303000													34	61					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61777953	61777953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:61777953C>T	ENST00000423902.2	+	38	8934	c.8455C>T	c.(8455-8457)Cct>Tct	p.P2819S	CHD7_ENST00000524602.1_Missense_Mutation_p.P770S	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2819					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GTTGAATAACCCTCTGTCAGC	0.547000													4	18					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	828709	828709	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:828709G>A	ENST00000293892.3	-	4	1012	c.1013C>T	c.(1012-1014)cCc>cTc	p.P338L	MSLNL_ENST00000442466.1_Missense_Mutation_p.P71L			Q96KJ4	MSLNL_HUMAN	mesothelin-like	71					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						CTGGTCCCGGGGCAGCTGGCT	0.692000													3	5					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679638	100679638	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100679638G>A	ENST00000306151.4	+	3	5005	c.4941G>A	c.(4939-4941)gaG>gaA	p.E1647E		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1647	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAGTCCTGAGGCTAGCACCC	0.502000													130	516					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148963691	148963691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148963691C>T	ENST00000434415.1	+	2	453	c.290C>T	c.(289-291)gCc>gTc	p.A97V		NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	97					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GGCAAGTGGGCCGTGCTGGGG	0.627000													30	99					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102714185	102714185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102714185C>T	ENST00000299855.5	-	1	349	c.93G>A	c.(91-93)atG>atA	p.M31I		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	31					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	GAACAAGGTTCATGCTGGTGT	0.488000													11	27					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173552675	173552675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173552675C>T	ENST00000367714.3	-	6	1032	c.610G>A	c.(610-612)Ggc>Agc	p.G204S	SLC9C2_ENST00000536496.1_Missense_Mutation_p.G102S|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	204					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										ATTCTGTTGCCCCGAAAATTT	0.279000													28	81					0	0	1	0	0
KCNN1	3780	broad.mit.edu	37	19	18092715	18092715	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18092715C>A	ENST00000601725.1	+	0	331																											TGCTGTCCATCCCCATGTTCC	0.672000													6	21					0.00198382	0.00198545	1	1	0
FAM65B	9750	broad.mit.edu	37	6	24848321	24848321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24848321G>A	ENST00000259698.4	-	12	1184	c.1009C>T	c.(1009-1011)Cag>Tag	p.Q337*	FAM65B_ENST00000510784.2_Nonsense_Mutation_p.Q371*|FAM65B_ENST00000378023.4_Nonsense_Mutation_p.Q337*|FAM65B_ENST00000538035.1_Nonsense_Mutation_p.Q366*|FAM65B_ENST00000540914.1_Nonsense_Mutation_p.Q337*	NM_014722.2	NP_055537.2	Q9Y4F9	FA65B_HUMAN	family with sequence similarity 65, member B	337					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	25						ATTCTCCTCTGAAGGGCTGCT	0.517000													15	23					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51376660	51376660	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:51376660G>A	ENST00000216392.7	-	17	2462	c.2130C>T	c.(2128-2130)ttC>ttT	p.F710F	PYGL_ENST00000532462.1_Silent_p.F710F|PYGL_ENST00000544180.2_Silent_p.F676F	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	710					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TGCCAAAGATGAACAGGTTCT	0.502000													119	288					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4945447	4945447	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4945447G>A	ENST00000321961.2	-	1	190	c.123C>T	c.(121-123)atC>atT	p.I41I	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGTTCCCCAAGATAACTGTCA	0.502000													18	63					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163241435	163241435	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163241435C>T	ENST00000332142.5	-	13	2824	c.2725G>A	c.(2725-2727)Gat>Aat	p.D909N		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	909					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TCTTCAGGATCATTTGTACTG	0.338000													36	70					0	0	1	0	0
AGAP6	414189	broad.mit.edu	37	10	51751483	51751483	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:51751483C>T	ENST00000374056.4	+	2	669	c.271C>T	c.(271-273)Cag>Tag	p.Q91*	AGAP6_ENST00000412531.3_Nonsense_Mutation_p.Q114*			C9IYN2	C9IYN2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 6	114					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(8)|prostate(3)|skin(1)|stomach(2)	29						CACAATATTCCAGAGGAACTC	0.348000													17	176					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85279804	85279804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85279804C>T	ENST00000440886.1	-	2	825	c.787G>A	c.(787-789)Ggc>Agc	p.G263S	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Missense_Mutation_p.G263S			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	263					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						CAGTTCAGGCCGTCGAGGAGC	0.582000													34	65					0	0	1	0	0
GPR21	2844	broad.mit.edu	37	9	125797421	125797421	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125797421C>T	ENST00000373642.1	+	1	616	c.576C>T	c.(574-576)acC>acT	p.T192T	RABGAP1_ENST00000373647.4_Intron|RABGAP1_ENST00000373643.5_Intron|RABGAP1_ENST00000493854.1_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	192						integral to plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						CCTACTTCACCCTGTTCATCG	0.493000													27	112					0	0	1	0	0
OXSM	54995	broad.mit.edu	37	3	25832704	25832704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:25832704C>T	ENST00000280701.3	+	2	292	c.193C>T	c.(193-195)Cgt>Tgt	p.R65C	OXSM_ENST00000420173.2_Missense_Mutation_p.R65C|OXSM_ENST00000449808.1_3'UTR	NM_017897.2	NP_060367.1	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial	65					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity	p.R65C(1)		breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						GGTTTGGGATCGTCTTATCGG	0.463000													57	134					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62299256	62299256	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62299256G>A	ENST00000378024.4	-	5	2907	c.2633C>T	c.(2632-2634)cCc>cTc	p.P878L	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	878					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTCATCTTGGGCATCTTCAG	0.498000													136	355					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42711363	42711363	+	Missense_Mutation	SNP	G	G	A	rs45590635		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:42711363G>A	ENST00000230882.4	+	7	863	c.673G>A	c.(673-675)Gaa>Aaa	p.E225K	GHR_ENST00000357703.3_Missense_Mutation_p.E203K|GHR_ENST00000537449.1_Missense_Mutation_p.E38K	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	225	Fibronectin type-III.				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AGTGGATAAGGAATATGAAGT	0.398000													26	171					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50472793	50472793	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50472793C>T	ENST00000266182.6	-	9	1019	c.1020G>A	c.(1018-1020)cgG>cgA	p.R340R	TTLL8_ENST00000440475.1_Silent_p.R324R					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CACCTCGGCCCCGGGACTTGG	0.597000													5	41					0	0	1	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23445473	23445473	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23445473C>T	ENST00000526079.1	+	0	2293					NR_027407.1|NR_033350.1																						ACATGACCATCGTCAAAGACC	0.433000													9	162					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7811414	7811414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:7811414G>A	ENST00000420658.1	-	9	1253	c.981C>T	c.(979-981)atC>atT	p.I327I	AFAP1_ENST00000382543.3_Silent_p.I327I|AFAP1_ENST00000358461.2_Silent_p.I327I|AFAP1_ENST00000360265.4_Silent_p.I327I	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	327						actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						CCAGACTGATGATCTTGGTGA	0.498000													22	40					0	0	1	0	0
CREG2	200407	broad.mit.edu	37	2	102000095	102000095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102000095G>A	ENST00000324768.4	-	2	648	c.511C>T	c.(511-513)Cct>Tct	p.P171S	CREG2_ENST00000495455.1_5'UTR	NM_153836.3	NP_722578.1	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2	171						extracellular region	FMN binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						TAGAAGAAAGGAATCCCAGTG	0.517000													23	63					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370370	126370370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126370370G>A	ENST00000394329.3	+	9	8212	c.8199G>A	c.(8197-8199)agG>agA	p.R2733R	FAT4_ENST00000335110.5_Silent_p.R1031R	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2733	Cadherin 26.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTTTGGACAGGGAAAAAGTAT	0.348000													8	140					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603011	138603011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138603011G>A	ENST00000440172.1	-	2	1409	c.1361C>T	c.(1360-1362)aCc>aTc	p.T454I	KIAA1549_ENST00000422774.1_Missense_Mutation_p.T454I|KIAA1549_ENST00000242365.4_Missense_Mutation_p.T404I	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	454						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TTCCAGCACGGTCATGCACAG	0.522000			O	BRAF	pilocytic astrocytoma								26	58					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969396	140969396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140969396G>A	ENST00000298296.1	+	4	723	c.723G>A	c.(721-723)ctG>ctA	p.L241L	MAGEC3_ENST00000536088.1_Intron|MAGEC3_ENST00000448920.1_Intron|MAGEC3_ENST00000443323.2_Intron	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	241	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					GCATTTCCCTGACAGAAGTGG	0.483000													78	65					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86124487	86124487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:86124487C>T	ENST00000394518.2	+	7	3283	c.3188C>T	c.(3187-3189)tCt>tTt	p.S1063F	AKAP13_ENST00000361243.2_Missense_Mutation_p.S1063F	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1063					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						AGTCAGCCTTCTCCTCTGGAT	0.532000													18	113					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89392839	89392839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89392839C>T	ENST00000439576.2	+	10	2277	c.1903C>T	c.(1903-1905)Ccc>Tcc	p.P635S	ACAN_ENST00000558207.1_Missense_Mutation_p.P635S|ACAN_ENST00000559004.1_Missense_Mutation_p.P635S|ACAN_ENST00000561243.1_Missense_Mutation_p.P635S|ACAN_ENST00000352105.7_Missense_Mutation_p.P635S	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	635					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCTCCGCTACCCCATCGTCAC	0.687000													6	21					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69682301	69682301	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69682301C>T	ENST00000265403.7	+	1	591	c.564C>T	c.(562-564)ttC>ttT	p.F188F	UGT2B10_ENST00000458688.2_Intron	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	188					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						GATTTATTTTCCCTCCTTCCT	0.398000													35	120					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51122405	51122405	+	Silent	SNP	C	C	T	rs61745502	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51122405C>T	ENST00000301180.5	+	30	3619	c.3585C>T	c.(3583-3585)atC>atT	p.I1195I		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	1195						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						CTCGGCAGATCGCCATCTGCC	0.527000													7	61					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32239700	32239700	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32239700C>T	ENST00000400246.1	+	29	2845	c.2703C>T	c.(2701-2703)ttC>ttT	p.F901F	DEPDC5_ENST00000400248.1_Silent_p.F892F|DEPDC5_ENST00000535622.1_Silent_p.F823F|DEPDC5_ENST00000382111.2_Silent_p.F901F|DEPDC5_ENST00000400249.2_Silent_p.F892F|DEPDC5_ENST00000266091.3_Silent_p.F901F|DEPDC5_ENST00000382105.2_Silent_p.F823F|DEPDC5_ENST00000382112.3_Silent_p.F892F			O75140	DEPD5_HUMAN	DEP domain containing 5	892					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ACTCAGAGTTCGTCTCCTGCT	0.493000													46	100					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72326435	72326435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72326435G>A	ENST00000263563.6	+	20	2785	c.2517G>A	c.(2515-2517)cgG>cgA	p.R839R		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		TGCGCTACCGGTGGCAGGAGC	0.677000													3	19					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857927	9857927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9857927G>A	ENST00000396573.2	-	14	3783	c.3474C>T	c.(3472-3474)ttC>ttT	p.F1158F	GRIN2A_ENST00000404927.2_Silent_p.F1158F|GRIN2A_ENST00000562109.1_Silent_p.F1158F|GRIN2A_ENST00000330684.3_Silent_p.F1158F|GRIN2A_ENST00000396575.2_Silent_p.F1158F|GRIN2A_ENST00000535259.1_Silent_p.F1001F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1158					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCCCCTTGCGGAAGTTTTCAC	0.527000													13	155					0	0	1	0	0
OR52M1	119772	broad.mit.edu	37	11	4566681	4566681	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4566681C>T	ENST00000360213.1	+	1	261	c.261C>T	c.(259-261)ttC>ttT	p.F87F		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGGAATCTTCTGGTTCGGTG	0.512000													23	78					0	0	1	0	0
C11orf52	91894	broad.mit.edu	37	11	111796863	111796863	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111796863G>A	ENST00000278601.5	+	4	408	c.312G>A	c.(310-312)gcG>gcA	p.A104A	HSPB2-C11orf52_ENST00000534100.1_3'UTR|C11orf52_ENST00000527286.1_3'UTR	NM_080659.2	NP_542390.2	Q96A22	CK052_HUMAN	chromosome 11 open reading frame 52	104										lung(2)|ovary(1)	3		all_cancers(61;8.8e-15)|all_epithelial(67;6.27e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.63e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.7e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0512)		CAGAGTATGCGACCCTTCGCT	0.547000													12	48					0	0	1	0	0
C9orf117	286207	broad.mit.edu	37	9	130473762	130473762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130473762G>A	ENST00000373295.2	+	4	882	c.842G>A	c.(841-843)aGa>aAa	p.R281K		NM_001012502.2	NP_001012520.2	Q5JU67	CI117_HUMAN	chromosome 9 open reading frame 117	281										breast(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	6						AGGCACAAAAGAGGCCACCAG	0.607000													13	62					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32705812	32705812	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32705812C>T	ENST00000380250.3	+	8	1216	c.720C>T	c.(718-720)ttC>ttT	p.F240F		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TTCTTAGATTCCCTGCTGTAA	0.418000													10	47					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22390168	22390168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:22390168G>A	ENST00000334304.5	-	19	3395	c.3126C>T	c.(3124-3126)ttC>ttT	p.F1042F	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	1042					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				GGTGGACCACGAAGAACGCAC	0.473000													50	32					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40572226	40572226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:40572226G>A	ENST00000342449.3	-	39	4750	c.4672C>T	c.(4672-4674)Cgt>Tgt	p.R1558C	BRWD1_ENST00000380800.3_Missense_Mutation_p.R1558C|BRWD1_ENST00000333229.2_Missense_Mutation_p.R1558C	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GAGGATTCACGAGCTCTGGAA	0.443000													23	88					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40076552	40076552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:40076552G>A	ENST00000324616.5	+	8	980	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K	C12orf40_ENST00000405531.3_Missense_Mutation_p.E276K|C12orf40_ENST00000398716.1_Missense_Mutation_p.E199K	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	276										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						AAATGGAAAGGAAGTTTCAAA	0.328000													37	120					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72233974	72233974	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:72233974G>A	ENST00000340726.3	-	6	1052	c.413C>T	c.(412-414)tCa>tTa	p.S138L	EYA1_ENST00000303824.7_Missense_Mutation_p.S137L|EYA1_ENST00000388742.4_Missense_Mutation_p.S138L|EYA1_ENST00000388741.2_Missense_Mutation_p.S104L|EYA1_ENST00000388743.2_Missense_Mutation_p.S137L|EYA1_ENST00000388740.3_Missense_Mutation_p.S105L|EYA1_ENST00000419131.1_Missense_Mutation_p.S138L	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	138					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CTCACCATATGAGGAAATGCC	0.483000													12	35					0	0	1	0	0
NFKBID	84807	broad.mit.edu	37	19	36387009	36387009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36387009G>A	ENST00000396901.1	-	9	1052	c.479C>T	c.(478-480)gCc>gTc	p.A160V	NFKBID_ENST00000352614.2_Missense_Mutation_p.A312V|NFKBID_ENST00000606253.1_Missense_Mutation_p.A160V	NM_139239.1	NP_640332.1	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta	160					inflammatory response	nucleus				breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	14						GGCCAGGATGGCCGTGTGGAG	0.642000													10	106					0	0	1	0	0
SEPT12	124404	broad.mit.edu	37	16	4827818	4827818	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4827818C>T	ENST00000268231.8	-	10	1320	c.1057G>A	c.(1057-1059)Gat>Aat	p.D353N	SEPT12_ENST00000396693.5_Missense_Mutation_p.D307N	NM_144605.4	NP_653206.2	Q8IYM1	SEP12_HUMAN	septin 12	353					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|skin(2)|stomach(3)	23						TCATCAGAATCGTCATGGGCC	0.662000													3	4					0	0	1	0	0
GLIPR1L1	256710	broad.mit.edu	37	12	75728596	75728596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:75728596G>A	ENST00000312442.2	+	1	134	c.88G>A	c.(88-90)Gac>Aac	p.D30N	CAPS2_ENST00000442339.2_Intron|GLIPR1L1_ENST00000378695.4_Missense_Mutation_p.D30N	NM_152779.2	NP_689992.1	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	30						extracellular region				endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10						ATCCATCACTGACCCACACTT	0.463000											OREG0021998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	67					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51864298	51864298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51864298C>T	ENST00000453097.2	+	13	1864	c.1647C>T	c.(1645-1647)ttC>ttT	p.F549F	SLC4A8_ENST00000394856.1_Silent_p.F496F|SLC4A8_ENST00000514353.3_Silent_p.F496F|SLC4A8_ENST00000546663.1_3'UTR|SLC4A8_ENST00000358657.3_Silent_p.F576F|SLC4A8_ENST00000535225.2_Silent_p.F496F	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	549					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		AGATTTTGTTCAAATTCTGCA	0.418000													30	129					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2432910	2432910	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2432910G>A	ENST00000452833.1	-	17	2576	c.2568C>T	c.(2566-2568)gcC>gcT	p.A856A	TRPM5_ENST00000528453.1_Silent_p.A854A|TRPM5_ENST00000155858.6_Silent_p.A854A|TRPM5_ENST00000533060.1_Silent_p.A854A			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	854						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCTTGTGTATGGCAAAGATAT	0.637000													35	64					0	0	1	0	0
MARCH5	54708	broad.mit.edu	37	10	94109519	94109519	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:94109519C>T	ENST00000358935.2	+	5	977	c.645C>T	c.(643-645)gtC>gtT	p.V215V	MARCH5_ENST00000467521.2_3'UTR	NM_017824.4	NP_060294.1	Q9NX47	MARH5_HUMAN	membrane-associated ring finger (C3HC4) 5	215					cell aging|protein autoubiquitination|protein localization in mitochondrion|protein polyubiquitination|regulation of mitochondrial fission	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	GTPase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GAGCCCTTGTCTTTCCTACTA	0.403000													95	175					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6756023	6756023	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6756023C>T	ENST00000229243.2	-	2	292	c.199G>A	c.(199-201)Ggc>Agc	p.G67S	ACRBP_ENST00000414226.2_Missense_Mutation_p.G67S|ACRBP_ENST00000536350.1_Missense_Mutation_p.G67S	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	67						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						TTCCGGCAGCCGTGGGTTGCA	0.602000													21	39					0	0	1	0	0
C19orf55	148137	broad.mit.edu	37	19	36255778	36255778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36255778C>T	ENST00000544099.1	+	6	630	c.567C>T	c.(565-567)tcC>tcT	p.S189S	C19orf55_ENST00000396908.4_Silent_p.S189S			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	189										cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGAACTCATCCCTGCTGGACC	0.627000													8	32					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81205386	81205386	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81205386C>T	ENST00000552864.1	-	5	762	c.560G>A	c.(559-561)cGa>cAa	p.R187Q		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	187	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						TGGGGTGTATCGCACCACCAG	0.483000													6	67					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171251235	171251235	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171251235A>C	ENST00000354841.4	+	6	1077	c.946A>C	c.(946-948)Act>Cct	p.T316P	FMO1_ENST00000402921.2_Missense_Mutation_p.T253P|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.T316P			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	316					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTTAACAATACTTCAAAGGA	0.418000													16	101					0	0	1	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103568561	103568561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:103568561C>T	ENST00000380069.3	+	2	577	c.501C>T	c.(499-501)acC>acT	p.T167T		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	167										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CCTCGCGCACCTTTGAGCAGG	0.662000													5	8					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49427388	49427388	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49427388G>A	ENST00000301067.7	-	39	11099	c.11100C>T	c.(11098-11100)ttC>ttT	p.F3700F		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGTTGCCAGGGAAGAAGCCCC	0.582000													28	99					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41454959	41454959	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41454959G>A	ENST00000599198.1	+	0	1350					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TGCCCACAGGGAAGCGGATTT	0.572000													14	37					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110451248	110451248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:110451248G>A	ENST00000260283.4	-	16	2706	c.2422C>T	c.(2422-2424)Cct>Tct	p.P808S	ARHGAP20_ENST00000524756.1_Missense_Mutation_p.P785S|ARHGAP20_ENST00000528829.1_Missense_Mutation_p.P772S|ARHGAP20_ENST00000529591.1_Missense_Mutation_p.P351S|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.P782S|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.P782S|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.P772S	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	808					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GAGGACATAGGACTATAAGAT	0.458000													44	106					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18751216	18751216	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18751216G>A	ENST00000396170.1	-	13	2647	c.1383C>T	c.(1381-1383)atC>atT	p.I461I	PTPN5_ENST00000396166.3_Silent_p.I99I|PTPN5_ENST00000477854.1_Silent_p.I297I|RP11-1081L13.4_ENST00000527285.1_RNA|PTPN5_ENST00000358540.2_Silent_p.I493I|PTPN5_ENST00000396171.4_Silent_p.I493I|PTPN5_ENST00000396167.2_Silent_p.I461I|PTPN5_ENST00000396168.1_Silent_p.I469I	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	493	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						TGCAGTGGACGATGATGGGGG	0.746000													8	25					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228556048	228556048	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228556048C>T	ENST00000570156.2	+	99	22643	c.22569C>T	c.(22567-22569)gtC>gtT	p.V7523V	OBSCN_ENST00000366707.4_Silent_p.V4200V|OBSCN_ENST00000422127.1_Silent_p.V6566V	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6566	Ig-like 55.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGTCAAGGTCTACATCCAGC	0.622000													3	8					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153026646	153026646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153026646C>T	ENST00000285900.5	+	3	722	c.379C>T	c.(379-381)Cct>Tct	p.P127S	GRIA1_ENST00000518783.1_Missense_Mutation_p.P137S|GRIA1_ENST00000521843.2_Missense_Mutation_p.P58S|GRIA1_ENST00000340592.5_Missense_Mutation_p.P127S|GRIA1_ENST00000448073.4_Missense_Mutation_p.P137S|GRIA1_ENST00000518862.1_3'UTR|GRIA1_ENST00000518142.1_Intron	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	127					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCAGCTGCGCCCTGAACTGCA	0.512000													20	139					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	72926360	72926360	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:72926360G>A	ENST00000553530.1	+	6	570	c.363G>A	c.(361-363)tcG>tcA	p.S121S	RGS6_ENST00000343854.6_Silent_p.S121S|RGS6_ENST00000553690.1_3'UTR|RGS6_ENST00000553525.1_Silent_p.S121S|RGS6_ENST00000404301.2_Silent_p.S121S|RGS6_ENST00000406236.4_Silent_p.S121S|RGS6_ENST00000434263.2_Silent_p.S52S|RGS6_ENST00000556437.1_Silent_p.S121S|RGS6_ENST00000407322.4_Silent_p.S121S|RGS6_ENST00000355512.6_Silent_p.S121S|RGS6_ENST00000555571.1_Silent_p.S121S|RGS6_ENST00000402788.2_Silent_p.S121S	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	121					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		TCTGGCCTTCGAACTGCTGGG	0.572000													19	68					0	0	1	0	0
EHF	26298	broad.mit.edu	37	11	34680082	34680082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:34680082C>T	ENST00000257831.3	+	8	731	c.610C>T	c.(610-612)Ccg>Tcg	p.P204S	EHF_ENST00000450654.2_Missense_Mutation_p.P181S|EHF_ENST00000530286.1_Missense_Mutation_p.P204S|EHF_ENST00000531794.1_Missense_Mutation_p.P226S|EHF_ENST00000533754.1_Missense_Mutation_p.P204S	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	204					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TTCATCAGACCCGAGAGGGAC	0.463000													29	49					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39755817	39755817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39755817G>A	ENST00000442448.1	-	11	1168	c.897C>T	c.(895-897)ttC>ttT	p.F299F	ERG_ENST00000398910.1_Silent_p.F300F|ERG_ENST00000398911.1_Silent_p.F299F|ERG_ENST00000398905.1_Silent_p.F292F|ERG_ENST00000417133.2_Silent_p.F323F|ERG_ENST00000288319.7_Silent_p.F316F|ERG_ENST00000398897.1_Silent_p.F200F|ERG_ENST00000453032.2_Silent_p.F224F|ERG_ENST00000398919.2_Silent_p.F323F|ERG_ENST00000398907.1_Silent_p.F293F	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	323					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				GCTCCAGGAGGAACTGCCAAA	0.587000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								16	61					0	0	1	0	0
ISG20L2	81875	broad.mit.edu	37	1	156697137	156697137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156697137G>A	ENST00000313146.6	-	1	1090	c.308C>T	c.(307-309)cCt>cTt	p.P103L	ISG20L2_ENST00000368219.1_Missense_Mutation_p.P103L	NM_030980.1	NP_112242.1	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene 20kDa-like 2	103					ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGAAGGGGCAGGGGTCAACCA	0.517000											OREG0013885	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	85					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132471079	132471079	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:132471079C>T	ENST00000333577.4	+	7	2167	c.2058C>T	c.(2056-2058)ctC>ctT	p.L686L	EP400_ENST00000332482.4_Silent_p.L613L|EP400_ENST00000389562.2_Silent_p.L649L|EP400_ENST00000389561.2_Silent_p.L650L|EP400_ENST00000330386.6_Silent_p.L650L			Q96L91	EP400_HUMAN	E1A binding protein p400	686					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CGACAAGGCTCCCTGTGGACC	0.652000													43	68					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74635433	74635433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74635433C>T	ENST00000358632.4	-	5	1096	c.401G>A	c.(400-402)gGa>gAa	p.G134E	CYP11A1_ENST00000541301.1_3'UTR|CYP11A1_ENST00000268053.6_Missense_Mutation_p.G292E|CYP11A1_ENST00000419019.2_Missense_Mutation_p.G134E	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	292					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GTGAACACTTCCTTTCTGTCT	0.517000													76	83					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168180980	168180980	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168180980C>T	ENST00000519560.1	-	17	2137	c.1718G>A	c.(1717-1719)cGa>cAa	p.R573Q	SLIT3_ENST00000332966.8_Missense_Mutation_p.R573Q|SLIT3_ENST00000404867.3_Missense_Mutation_p.R573Q	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	573					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCTCCCTCTCGCACCTCCTT	0.552000													6	15					0	0	1	0	0
FASTKD5	60493	broad.mit.edu	37	20	3129117	3129117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3129117G>A	ENST00000380266.3	-	2	921	c.600C>T	c.(598-600)ctC>ctT	p.L200L	UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	200					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						GGGTATCAAAGAGCTGTATCT	0.463000													27	109					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882050	228882050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228882050G>A	ENST00000392056.3	-	7	3566	c.3520C>T	c.(3520-3522)Ctc>Ttc	p.L1174F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.L1174F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1174						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCACACTGAGGTGGTCACTT	0.527000													8	72					0	0	1	0	0
WNT11	7481	broad.mit.edu	37	11	75898246	75898246	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75898246C>T	ENST00000322563.3	-	5	1052	c.928G>A	c.(928-930)Gac>Aac	p.D310N		NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	310					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						CACATAAGGTCGCAGCTGTCG	0.607000													22	41					0	0	1	0	0
TMEM45B	120224	broad.mit.edu	37	11	129722454	129722454	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:129722454C>T	ENST00000281441.3	+	2	165	c.77C>T	c.(76-78)cCg>cTg	p.P26L	TMEM45B_ENST00000524567.1_Missense_Mutation_p.P26L	NM_138788.3	NP_620143.1	Q96B21	TM45B_HUMAN	transmembrane protein 45B	26						integral to membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		GTGAAGTACCCGCTGAAGTAC	0.493000													13	105					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115439700	115439700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:115439700G>A	ENST00000393780.3	+	4	1264	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K	GAP43_ENST00000305124.6_Missense_Mutation_p.E230K	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	230					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		TAAAGAAGAGGAACCTGAGGC	0.507000													20	314					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60741964	60741964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:60741964G>A	ENST00000303375.5	+	2	576	c.174G>A	c.(172-174)caG>caA	p.Q58Q		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	58	Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						TGGAGGCCCAGGGCGGGCAGG	0.622000													35	93					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534203	92534203	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92534203C>T	ENST00000298047.6	+	9	8041	c.8024C>T	c.(8023-8025)tCg>tTg	p.S2675L	FAT3_ENST00000409404.2_Missense_Mutation_p.S2675L|FAT3_ENST00000525166.1_Missense_Mutation_p.S2525L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2675	Cadherin 24.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACAGTGCTTTCGTTCTTTGTC	0.483000										TCGA Ovarian(4;0.039)			15	32					0	0	1	0	0
CYP2E1	1571	broad.mit.edu	37	10	135346307	135346307	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:135346307C>T	ENST00000463117.2	+	7	1032	c.760C>T	c.(760-762)Cat>Tat	p.H254Y	CYP2E1_ENST00000252945.3_Missense_Mutation_p.H254Y|SPRN_ENST00000541506.1_Intron			P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E, polypeptide 1	254					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			NS(1)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(7)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	GAAGGAGCACCATCAATCTCT	0.522000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				35	93					0	0	1	0	0
FYCO1	79443	broad.mit.edu	37	3	46023068	46023068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46023068G>A	ENST00000296137.2	-	3	361	c.156C>T	c.(154-156)ctC>ctT	p.L52L	FYCO1_ENST00000535325.1_Silent_p.L52L	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	52	RUN.				transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		TTACTTGCAGGAGATACTCAA	0.418000													11	46					0	0	1	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44612310	44612310	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44612310C>T	ENST00000273320.3	+	6	2137	c.1708C>T	c.(1708-1710)Cag>Tag	p.Q570*	ZKSCAN7_ENST00000431636.1_Intron|ZKSCAN7_ENST00000426540.1_Nonsense_Mutation_p.Q570*|RP11-944L7.4_ENST00000457331.1_RNA|ZKSCAN7_ENST00000341840.3_Intron	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		TATTCGACATCAGAGCCTCCA	0.438000													32	101					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058656	9058656	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9058656G>A	ENST00000397910.4	-	3	28993	c.28790C>T	c.(28789-28791)tCc>tTc	p.S9597F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9599	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCTCTGTGGATGAGGTGAT	0.527000													15	38					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160520779	160520779	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160520779C>T	ENST00000368054.3	-	5	842	c.807G>A	c.(805-807)agG>agA	p.R269R	CD84_ENST00000368051.3_Intron|CD84_ENST00000534968.1_Silent_p.R155R|CD84_ENST00000368048.3_Silent_p.R280R|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000311224.4_Silent_p.R286R	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	286					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GCTGGGTGTTCCTTGAAGCCA	0.443000													50	231					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28928094	28928094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:28928094G>A	ENST00000524189.1	-	40	5446	c.5408C>T	c.(5407-5409)tCg>tTg	p.S1803L	KIF13B_ENST00000404075.3_Missense_Mutation_p.S322L	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1803					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		AGCTGTCAGCGAGGCCAGGTT	0.706000													6	12					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50264894	50264894	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50264894C>T	ENST00000284509.6	-	13	1269	c.1128G>A	c.(1126-1128)acG>acA	p.T376T	ATP8B4_ENST00000559829.1_Silent_p.T376T	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	376					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGAGCGTGGTCGTTCGAGCCA	0.418000													16	44					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230462	147230462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:147230462G>A	ENST00000271348.2	-	2	1046	c.885C>T	c.(883-885)aaC>aaT	p.N295N	RP11-433J22.2_ENST00000428911.1_RNA|GJA5_ENST00000369237.1_Silent_p.N295N	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	295					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CGGTGACCAGGTTGTCTGTGT	0.532000													31	133					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811137	23811137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23811137G>A	ENST00000314520.3	+	1	684	c.208G>A	c.(208-210)Gga>Aga	p.G70R	MKRN3_ENST00000564592.1_Missense_Mutation_p.G70R|MKRN3_ENST00000568252.1_Missense_Mutation_p.G70R	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	70						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CCTCCGCAGAGGAGGCCTGAG	0.657000													4	51					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4513637	4513637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4513637C>T	ENST00000301286.3	-	3	292	c.293G>A	c.(292-294)aGc>aAc	p.S98N		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	98	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						GTCCACCACGCTGGCCACCCC	0.637000													5	15					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76455287	76455287	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76455287G>A	ENST00000389840.5	-	61	9739	c.9615C>T	c.(9613-9615)ccC>ccT	p.P3205P	DNAH17_ENST00000585328.1_Silent_p.P3214P|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGCCTTGGTAGGGCCTAGCGA	0.647000													54	158					0	0	1	0	0
C18orf25	147339	broad.mit.edu	37	18	43796275	43796275	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43796275C>T	ENST00000282059.6	+	2	803	c.429C>T	c.(427-429)tcC>tcT	p.S143S	C18orf25_ENST00000321319.6_Silent_p.S143S	NM_145055.3	NP_659492.1	Q96B23	CR025_HUMAN	chromosome 18 open reading frame 25	143										central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	11						CTAGGCGGTCCCGATCTGAAA	0.537000													7	100					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50813007	50813007	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50813007C>T	ENST00000440075.2	+	43	6118	c.6071C>T	c.(6070-6072)tCc>tTc	p.S2024F	MYH14_ENST00000425460.1_Missense_Mutation_p.S1991F|MYH14_ENST00000376970.2_Missense_Mutation_p.S2016F|MYH14_ENST00000598205.1_Missense_Mutation_p.S1991F|MYH14_ENST00000596571.1_Missense_Mutation_p.S1983F|MYH14_ENST00000262269.8_Missense_Mutation_p.S2024F|MYH14_ENST00000601313.1_Missense_Mutation_p.S2024F			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1983					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		TCTGGGCCATCCCCGGAGCCT	0.682000													5	5					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100348964	100348964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100348964G>A	ENST00000437033.2	-	5	1033	c.530C>T	c.(529-531)tCc>tTc	p.S177F	ADH7_ENST00000209665.4_Missense_Mutation_p.S189F|ADH7_ENST00000476959.1_Missense_Mutation_p.S197F|ADH7_ENST00000482593.1_Missense_Mutation_p.S120F			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	189					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	ATATCCAGTGGAAAACCCACA	0.408000													19	43					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153190713	153190713	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153190713C>T	ENST00000285900.5	+	16	2992	c.2649C>T	c.(2647-2649)ttC>ttT	p.F883F	GRIA1_ENST00000518783.1_Silent_p.F893F|GRIA1_ENST00000521843.2_Silent_p.F814F|GRIA1_ENST00000340592.5_Silent_p.F883F|GRIA1_ENST00000448073.4_Silent_p.F893F|GRIA1_ENST00000518142.1_Silent_p.F803F	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	883					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GCCATGACTTCCCCAAGTCCA	0.607000													39	32					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47941136	47941136	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:47941136C>T	ENST00000236877.6	-	7	2375	c.1980G>A	c.(1978-1980)gaG>gaA	p.E660E	SLC8A2_ENST00000542837.1_Silent_p.E416E|SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000539381.1_Silent_p.E123E	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	660					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CGATGATGACCTCCAGCCGGC	0.577000													36	98					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72344257	72344257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:72344257C>T	ENST00000299687.5	+	1	1282	c.1282C>T	c.(1282-1284)Cgt>Tgt	p.R428C	ZNF407_ENST00000582337.1_Missense_Mutation_p.R428C|ZNF407_ENST00000577538.1_Missense_Mutation_p.R428C|ZNF407_ENST00000309902.6_Missense_Mutation_p.R428C	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TAATAGCTTTCGTCGACGAAG	0.423000													15	81					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175409	51175409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51175409G>A	ENST00000440970.1	-	2	864	c.433C>T	c.(433-435)Cac>Tac	p.H145Y	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.H242Y|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	242					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGCAGCTGGTGGATCTGCTGC	0.547000													25	121					0	0	1	0	0
SH2D1B	117157	broad.mit.edu	37	1	162368760	162368760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:162368760G>A	ENST00000367929.2	-	3	425	c.316C>T	c.(316-318)Ccc>Tcc	p.P106S	SH2D1B_ENST00000359567.3_Intron	NM_053282.4	NP_444512.2	O14796	SH21B_HUMAN	SH2 domain containing 1B	106										kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			CTCAAGCTGGGGCTGGTTCTC	0.408000													34	73					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89953918	89953918	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89953918C>T	ENST00000405460.2	+	21	4671	c.4575C>T	c.(4573-4575)ttC>ttT	p.F1525F		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1525	Calx-beta 10.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACAAATCATTCATTATTTCTG	0.358000													36	94					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90770546	90770546	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:90770546G>A	ENST00000354366.3	-	5	970	c.738C>T	c.(736-738)ccC>ccT	p.P246P	NRDE2_ENST00000357904.3_Silent_p.P15P	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		GCTCAGATGAGGGAGGTTCAG	0.448000													43	119					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247597449	247597449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247597449C>T	ENST00000366497.2	+	6	3152	c.2372C>T	c.(2371-2373)tCc>tTc	p.S791F	NLRP3_ENST00000366496.2_Missense_Mutation_p.S791F|NLRP3_ENST00000336119.3_Missense_Mutation_p.S791F|NLRP3_ENST00000348069.2_Missense_Mutation_p.S734F|NLRP3_ENST00000391828.3_Missense_Mutation_p.S791F|NLRP3_ENST00000391827.2_Missense_Mutation_p.S734F	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	848					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TTCGACATCTCCTTGGTCCTC	0.567000													41	99					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848833	54848833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54848833G>A	ENST00000291759.4	-	5	846	c.790C>T	c.(790-792)Ccc>Tcc	p.P264S		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	264	Ig-like C2-type 3.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GGGCGCTGGGGGAGGCCATCG	0.662000													21	24					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46771680	46771680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:46771680G>A	ENST00000394809.4	-	3	1059	c.944C>T	c.(943-945)cCt>cTt	p.P315L	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	315					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CAGCCCTGGAGGCCCTGGGCA	0.657000													30	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179474049	179474049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179474049C>T	ENST00000589042.1	-	273	52212	c.51988G>A	c.(51988-51990)Gga>Aga	p.G17330R	TTN_ENST00000342992.6_Missense_Mutation_p.G14762R|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G8265R|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G8457R|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G8390R|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G15689R|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15689	Fibronectin type-III 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGATTCTCCCTTTTTGCTG	0.463000													10	51					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173596232	173596232	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173596232C>T	ENST00000333279.2	-	4	623	c.563G>A	c.(562-564)gGa>gAa	p.G188E		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	204										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						TTTCCCTGATCCCTTTTCTGT	0.358000													31	114					0	0	1	0	0
TRIM7	81786	broad.mit.edu	37	5	180625718	180625718	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:180625718G>T	ENST00000393315.1	-	5	1033	c.336C>A	c.(334-336)gtC>gtA	p.V112V	CTC-338M12.6_ENST00000502812.2_RNA|TRIM7_ENST00000393319.3_Silent_p.V138V|CTC-338M12.6_ENST00000512508.1_RNA|TRIM7_ENST00000504241.1_5'UTR|TRIM7_ENST00000361809.3_Silent_p.V112V|TRIM7_ENST00000422067.2_Silent_p.V112V|TRIM7_ENST00000274773.7_Silent_p.V320V|CTC-338M12.6_ENST00000509080.1_RNA	NM_203296.1	NP_976041.1	Q9C029	TRIM7_HUMAN	tripartite motif containing 7	320						cytoplasm|nucleus	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|stomach(1)	17	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		TCCCTTTTAAGACAAAGGTCT	0.537000													12	53					6.72482e-11	6.75262e-11	1	1	0
MTTP	4547	broad.mit.edu	37	4	100504621	100504621	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:100504621G>A	ENST00000457717.1	+	4	596	c.340G>A	c.(340-342)Gaa>Aaa	p.E114K	MTTP_ENST00000265517.5_Missense_Mutation_p.E114K|MTTP_ENST00000422897.2_Missense_Mutation_p.E114K|MTTP_ENST00000511045.1_Missense_Mutation_p.E141K	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	114	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	AATGGGAAAGGAAAACTTGGA	0.393000													39	100					0	0	1	0	0
CYP24A1	1591	broad.mit.edu	37	20	52789509	52789509	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:52789509C>T	ENST00000216862.3	-	2	781	c.388G>A	c.(388-390)Gag>Aag	p.E130K	CYP24A1_ENST00000395955.3_Missense_Mutation_p.E130K	NM_000782.4	NP_000773.2	Q07973	CP24A_HUMAN	cytochrome P450, family 24, subfamily A, polypeptide 1	130					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GGTTTGATCTCCAGCCGCTGC	0.622000													39	69					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53613787	53613787	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:53613787G>A	ENST00000342160.3	-	37	5154	c.4697C>T	c.(4696-4698)cCc>cTc	p.P1566L	HUWE1_ENST00000218328.8_Missense_Mutation_p.P1566L|HUWE1_ENST00000262854.6_Missense_Mutation_p.P1566L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1566					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTGGAGGCAGGGCTGAACCAC	0.488000													12	22					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88485422	88485422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:88485422C>T	ENST00000324166.5	+	8	2926	c.1235C>T	c.(1234-1236)cCc>cTc	p.P412L	THNSL2_ENST00000496844.1_3'UTR|THNSL2_ENST00000449349.1_Missense_Mutation_p.P238S|THNSL2_ENST00000358591.2_Missense_Mutation_p.P412L|THNSL2_ENST00000377254.3_Silent_p.S361S|THNSL2_ENST00000343544.4_3'UTR	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	412					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						CACAGCACTCCCCGGTGCTGC	0.617000													4	9					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159912807	159912807	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159912807G>A	ENST00000368094.1	-	3	390	c.193C>T	c.(193-195)Ccc>Tcc	p.P65S	IGSF9_ENST00000361509.3_Missense_Mutation_p.P65S	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	65	Ig-like 1.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGAAGATGGGAAGCAGGAAT	0.612000													13	51					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227915826	227915826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227915826C>T	ENST00000396625.3	-	33	3224	c.3017G>A	c.(3016-3018)aGa>aAa	p.R1006K	COL4A4_ENST00000329662.7_Missense_Mutation_p.R1006K	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1006	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGGTCCGTATCTTCCCGGCTC	0.547000													36	132					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179650431	179650431	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179650431G>A	ENST00000589042.1	-	15	2633	c.2409C>T	c.(2407-2409)gtC>gtT	p.V803V	TTN_ENST00000342992.6_Silent_p.V803V|TTN_ENST00000360870.5_Silent_p.V803V|TTN_ENST00000460472.2_Silent_p.V757V|TTN_ENST00000342175.6_Silent_p.V757V|TTN_ENST00000359218.5_Silent_p.V757V|TTN_ENST00000591111.1_Silent_p.V803V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	803							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCCACATGGACTAATCTTT	0.418000													34	98					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36995279	36995279	+	Silent	SNP	G	G	A	rs147433704		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36995279G>A	ENST00000274963.8	+	15	1851	c.1680G>A	c.(1678-1680)aaG>aaA	p.K560K		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	560	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						AGTGGGGCAAGAGCGGCCCCC	0.637000													27	133					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486595	125486595	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125486595G>A	ENST00000259466.1	+	1	327	c.327G>A	c.(325-327)ggG>ggA	p.G109G		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						TGGCATTTGGGAACACTGACA	0.483000													9	140					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	657217	657217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:657217C>T	ENST00000266383.5	+	8	748	c.735C>T	c.(733-735)ttC>ttT	p.F245F	B4GALNT3_ENST00000544638.1_3'UTR	NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	245						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGTACTACTTCGAGGTGCTGC	0.642000													20	36					0	0	1	0	0
IL12RB1	3594	broad.mit.edu	37	19	18170851	18170851	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18170851G>A	ENST00000600835.1	-	17	2139	c.1836C>T	c.(1834-1836)tcC>tcT	p.S612S	IL12RB1_ENST00000593993.1_Silent_p.S612S|IL12RB1_ENST00000430026.2_Silent_p.S612S			P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1	612					cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			endometrium(1)|kidney(1)|lung(3)|pancreas(1)|skin(2)	8						CCTCCTGCAGGGATGCCTCTT	0.607000													3	17					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62758479	62758479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:62758479G>A	ENST00000512091.1	+	9	2129	c.1382G>A	c.(1381-1383)gGa>gAa	p.G461E	LPHN3_ENST00000507164.1_Missense_Mutation_p.G529E|LPHN3_ENST00000506746.1_Missense_Mutation_p.G529E|LPHN3_ENST00000514591.1_Missense_Mutation_p.G461E|LPHN3_ENST00000545650.1_Missense_Mutation_p.G461E|LPHN3_ENST00000508693.1_Missense_Mutation_p.G529E|LPHN3_ENST00000504896.1_Missense_Mutation_p.G461E|LPHN3_ENST00000514996.1_Missense_Mutation_p.G461E|LPHN3_ENST00000511324.1_Missense_Mutation_p.G529E|LPHN3_ENST00000507625.1_Missense_Mutation_p.G529E|LPHN3_ENST00000509896.1_Missense_Mutation_p.G529E|LPHN3_ENST00000508946.1_Missense_Mutation_p.G461E|LPHN3_ENST00000506720.1_Missense_Mutation_p.G529E|LPHN3_ENST00000506700.1_Missense_Mutation_p.G461E|LPHN3_ENST00000514157.1_Missense_Mutation_p.G461E			Q9HAR2	LPHN3_HUMAN	latrophilin 3	461					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TCAGTGTCAGGAAGAAGAAAC	0.542000													26	70					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79461839	79461839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79461839C>T	ENST00000264895.6	+	74	12040	c.11600C>T	c.(11599-11601)tCc>tTc	p.S3867F		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3862					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTTGATGATTCCCTCATCTAT	0.552000													8	25					0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978303	10978303	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10978303G>A	ENST00000240619.2	-	1	654	c.566C>T	c.(565-567)tCc>tTc	p.S189F		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	189					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						TGTAATTAGGGATAGTGTAAA	0.358000													32	64					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157771	26157771	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:26157771G>A	ENST00000325250.1	+	2	856	c.669G>A	c.(667-669)atG>atA	p.M223I		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	223	MAGE.						protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						GGGAAATTATGAATATGATGG	0.473000													6	6					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105645016	105645016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:105645016C>T	ENST00000542731.1	+	8	1043	c.935C>T	c.(934-936)tCc>tTc	p.S312F	CDHR3_ENST00000470188.1_3'UTR|CDHR3_ENST00000541203.1_3'UTR|CDHR3_ENST00000343407.5_Missense_Mutation_p.S29F|CDHR3_ENST00000478080.1_Missense_Mutation_p.S224F|CDHR3_ENST00000317716.9_Missense_Mutation_p.S312F			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	312	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CCCACCATTTCCCTGGAAGTT	0.483000													11	33					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25839905	25839905	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25839905G>A	ENST00000376351.3	+	6	1764	c.1404_splice	c.e6-1	p.V469_splice		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	469						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CATCCCACAGGTTGTTATTTT	0.408000													28	85					0	0	1	0	0
SDAD1	55153	broad.mit.edu	37	4	76879000	76879000	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76879000G>A	ENST00000356260.5	-	18	1696	c.1578_splice	c.e18+1	p.I526_splice	SDAD1_ENST00000395711.4_Splice_Site_p.I489_splice	NM_018115.2	NP_060585.2	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	526					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCAGACTTACGATTTCTTGCT	0.423000													58	127					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23398129	23398129	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23398129G>A	ENST00000379361.4	+	2	1633	c.773G>A	c.(772-774)aGg>aAg	p.R258K		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	258					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TCCTCACTGAGGGAAGATTTC	0.517000													84	46					0	0	1	0	0
TESC	54997	broad.mit.edu	37	12	117486949	117486949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117486949C>T	ENST00000335209.7	-	4	410	c.224G>A	c.(223-225)gGa>gAa	p.G75E	TESC_ENST00000535198.1_5'UTR|TESC_ENST00000392545.4_Missense_Mutation_p.G128E|TESC_ENST00000541210.1_Missense_Mutation_p.G48E			Q96BS2	TESC_HUMAN	tescalcin	75					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		GCCACTGGGTCCCTTGCGCAG	0.537000													17	71					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89949435	89949435	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89949435G>A	ENST00000405460.2	+	20	4140	c.4044G>A	c.(4042-4044)agG>agA	p.R1348R		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1348					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATCCCTCCAGGAATAATACAA	0.448000													7	18					0	0	1	0	0
STARD8	9754	broad.mit.edu	37	X	67938308	67938308	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:67938308G>A	ENST00000252336.6	+	5	1684	c.1312G>A	c.(1312-1314)Gga>Aga	p.G438R	STARD8_ENST00000374597.3_Missense_Mutation_p.G438R|STARD8_ENST00000374599.3_Missense_Mutation_p.G518R	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	438					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						TGTGGAAGAAGGACACTCCAT	0.642000													16	8					0	0	1	0	0
ATL2	64225	broad.mit.edu	37	2	38525591	38525591	+	Missense_Mutation	SNP	G	G	A	rs116493165	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:38525591G>A	ENST00000378954.4	-	12	1328	c.1327C>T	c.(1327-1329)Cgt>Tgt	p.R443C	ATL2_ENST00000419554.2_Missense_Mutation_p.R443C|ATL2_ENST00000406122.1_Missense_Mutation_p.R272C|ATL2_ENST00000452935.2_Missense_Mutation_p.R425C|ATL2_ENST00000546051.1_Missense_Mutation_p.R272C|ATL2_ENST00000539122.1_Missense_Mutation_p.R272C|ATL2_ENST00000402054.1_Missense_Mutation_p.R272C|ATL2_ENST00000332337.4_Missense_Mutation_p.R425C	NM_001135673.1|NM_022374.2	NP_001129145.1|NP_071769.2	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2	443					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22						TCCTGATAACGACGGCAGAAC	0.418000													17	217					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207195413	207195413	+	Missense_Mutation	SNP	G	G	A	rs147463881		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207195413G>A	ENST00000359470.5	-	4	1945	c.1696C>T	c.(1696-1698)Cgt>Tgt	p.R566C	C1orf116_ENST00000461135.2_Missense_Mutation_p.R320C	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	566						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					AGCTTGTCACGGCTCTGTCCT	0.587000													16	43					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157650834	157650834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157650834G>A	ENST00000368184.3	-	12	2185	c.1894C>T	c.(1894-1896)Cct>Tct	p.P632S	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Missense_Mutation_p.P632S	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	632						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GGCTCTTGAGGGTCTATCCTG	0.542000													16	36					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131522171	131522171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131522171C>T	ENST00000423981.1	+	2	2636	c.2526C>T	c.(2524-2526)ctC>ctT	p.L842L	AMER3_ENST00000321420.4_Silent_p.L842L	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GTGAGGGCCTCCTCTGTGGCC	0.627000													8	14					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324651	79324651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79324651C>T	ENST00000428286.1	-	8	2662	c.1462G>A	c.(1462-1464)Gaa>Aaa	p.E488K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E847K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	847					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCCAGTAGTTCTGAAGAAGAA	0.463000													11	28					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127796962	127796962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:127796962C>T	ENST00000556132.1	-	6	3073	c.2209G>A	c.(2209-2211)Gac>Aac	p.D737N	SOGA3_ENST00000481848.2_Missense_Mutation_p.D737N|SOGA3_ENST00000525778.1_Missense_Mutation_p.D737N|SOGA3_ENST00000368268.2_Missense_Mutation_p.D737N|SOGA3_ENST00000465909.2_Missense_Mutation_p.D737N	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	737						integral to membrane											GAGGCCAGGTCGTAGCGCTGC	0.677000													54	50					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24959159	24959159	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24959159T>A	ENST00000396432.2	-	3	717	c.231A>T	c.(229-231)caA>caT	p.Q77H		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	76	PDZ.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TATATGAAAATTGAATTGCAG	0.398000													28	49					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124407	142124407	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142124407G>A	ENST00000390376.2	-	0	70																											TGGGGTCTGAGTGACACCAGC	0.532000													30	50					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61555329	61555329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61555329C>T	ENST00000290866.4	+	2	311	c.287C>T	c.(286-288)gCc>gTc	p.A96V	ACE_ENST00000538928.1_Missense_Mutation_p.A96V|ACE_ENST00000428043.1_Missense_Mutation_p.A96V|ACE_ENST00000584529.1_3'UTR	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	96	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TTTGCGGAGGCCTGGGGCCAG	0.622000													11	18					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516686	140516686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140516686C>T	ENST00000231134.5	+	1	1887	c.1670C>T	c.(1669-1671)tCg>tTg	p.S557L		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		557	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACGACAACTCGCCCTTCGTG	0.716000													30	59					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460392	107460392	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107460392G>A	ENST00000409382.3	-	2	652	c.42C>T	c.(40-42)ttC>ttT	p.F14F	ST6GAL2_ENST00000361686.4_Silent_p.F14F|ST6GAL2_ENST00000409087.3_Silent_p.F14F	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	14					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CGAATATTCCGAAAAGCATTC	0.512000													23	55					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31286729	31286729	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31286729G>A	ENST00000332585.6	+	8	1742	c.1638G>A	c.(1636-1638)gaG>gaA	p.E546E	OSBP2_ENST00000401475.1_Silent_p.E179E|OSBP2_ENST00000535268.1_Silent_p.E90E|OSBP2_ENST00000407373.1_Silent_p.E373E|OSBP2_ENST00000403222.3_Silent_p.E380E|OSBP2_ENST00000446658.2_Silent_p.E545E|OSBP2_ENST00000382310.3_Silent_p.E497E|OSBP2_ENST00000437268.2_Silent_p.E288E	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	546					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						ACTTCAATGAGCCCCTGTCCA	0.612000											OREG0026467	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	37					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38830220	38830220	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38830220G>A	ENST00000359357.3	+	42	5899	c.5645G>A	c.(5644-5646)gGa>gAa	p.G1882E	DNAH8_ENST00000449981.2_Missense_Mutation_p.G2099E|DNAH8_ENST00000441566.1_Missense_Mutation_p.G1882E					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGAGGCCTAGGAAGGATTTTC	0.348000													40	91					0	0	1	0	0
CSF1	1435	broad.mit.edu	37	1	110466201	110466201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110466201G>A	ENST00000329608.6	+	6	1349	c.958G>A	c.(958-960)Ggg>Agg	p.G320R	CSF1_ENST00000420111.2_Intron|CSF1_ENST00000369802.3_Missense_Mutation_p.G320R|CSF1_ENST00000344188.5_Missense_Mutation_p.G320R|CSF1_ENST00000369801.1_Missense_Mutation_p.G320R	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	320					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGTACCCCAAGGGACAGAGCT	0.587000											OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	77					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70946574	70946574	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70946574C>T	ENST00000334414.6	-	21	5414	c.5370G>A	c.(5368-5370)aaG>aaA	p.K1790K	PTPRB_ENST00000550857.1_Silent_p.K1482K|PTPRB_ENST00000451516.2_Silent_p.K1482K|PTPRB_ENST00000550358.1_Silent_p.K1702K|PTPRB_ENST00000538708.1_Silent_p.K1482K|PTPRB_ENST00000261266.5_Silent_p.K1572K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1572	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CAGTGTGTGGCTTCAGTGGTC	0.453000													13	47					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034117	52034117	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52034117C>T	ENST00000346477.3	-	3	592	c.524G>A	c.(523-525)gGg>gAg	p.G175E	SIGLEC6_ENST00000359982.4_Missense_Mutation_p.G175E|SIGLEC6_ENST00000391797.3_Missense_Mutation_p.G164E|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.G175E|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.G139E|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.G175E	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	175	Ig-like C2-type 1.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GGGGGGCGTCCCCTGCTCACA	0.667000													41	101					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61542375	61542375	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61542375G>A	ENST00000266070.4	-	3	915	c.590C>T	c.(589-591)cCc>cTc	p.P197L	DIDO1_ENST00000370371.4_Missense_Mutation_p.P197L|DIDO1_ENST00000395340.1_Missense_Mutation_p.P197L|DIDO1_ENST00000395335.2_Missense_Mutation_p.P197L|DIDO1_ENST00000354665.4_Missense_Mutation_p.P197L|DIDO1_ENST00000266071.5_Missense_Mutation_p.P197L|DIDO1_ENST00000370368.1_Missense_Mutation_p.P197L|DIDO1_ENST00000370366.1_Missense_Mutation_p.P197L|DIDO1_ENST00000395343.1_Missense_Mutation_p.P197L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	197					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					AGTCTCGGCGGGACCCTCCTC	0.657000													28	35					0	0	1	0	0
PANX1	24145	broad.mit.edu	37	11	93911540	93911540	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93911540C>T	ENST00000227638.3	+	3	712	c.327C>T	c.(325-327)ttC>ttT	p.F109F	PANX1_ENST00000436171.2_Silent_p.F109F	NM_015368.3	NP_056183.2	Q96RD7	PANX1_HUMAN	pannexin 1	109					positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding			endometrium(2)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTCAGTTTTTCCCCTACATCC	0.478000													15	64					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116429355	116429355	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:116429355G>A	ENST00000281928.3	-	17	3610	c.3404C>T	c.(3403-3405)gCc>gTc	p.A1135V		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1135					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CATGTTGCAGGCACAGATGCA	0.483000													37	60					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121745926	121745926	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:121745926G>A	ENST00000452319.1	+	14	2496	c.2436G>A	c.(2434-2436)acG>acA	p.T812T	GLI2_ENST00000361492.4_Silent_p.T812T|GLI2_ENST00000314490.11_Silent_p.T484T			P10070	GLI2_HUMAN	GLI family zinc finger 2	812	Ser-rich.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCACCAGCACGGTCAGCTCGG	0.746000													9	17					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109937499	109937499	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109937499C>T	ENST00000342494.3	+	12	1597	c.1002C>T	c.(1000-1002)ttC>ttT	p.F334F	UBE3B_ENST00000434735.2_Silent_p.F334F|UBE3B_ENST00000280774.5_Silent_p.F334F	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	334					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CAGATGGGTTCGTGAGTTTGC	0.557000													8	36					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1443182	1443182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:1443182G>A	ENST00000446702.2	+	21	3397	c.2770G>A	c.(2770-2772)Gag>Aag	p.E924K	CNTN6_ENST00000539053.1_Missense_Mutation_p.E852K|CNTN6_ENST00000350110.2_Missense_Mutation_p.E924K			Q9UQ52	CNTN6_HUMAN	contactin 6	924	Fibronectin type-III 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CTTGAACTGGGAGCATGTAAA	0.353000													14	58					0	0	1	0	0
ALDOB	229	broad.mit.edu	37	9	104189916	104189916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104189916C>T	ENST00000374855.4	-	5	512	c.388G>A	c.(388-390)Ggc>Agc	p.G130S	ALDOB_ENST00000468981.2_Intron	NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	130					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				TCTGAGAGGCCATCAAGCCCT	0.507000													30	51					0	0	1	0	0
GRINA	2907	broad.mit.edu	37	8	145065532	145065532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145065532C>T	ENST00000313269.5	+	2	419	c.141C>T	c.(139-141)ttC>ttT	p.F47F	GRINA_ENST00000395068.4_Silent_p.F47F	NM_000837.1	NP_000828.1	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	47	Pro-rich.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	9	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGCCCCCTTTCCAGCCCTCCC	0.706000													3	19					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778532	31778532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31778532C>T	ENST00000375654.4	-	2	1407	c.1218G>A	c.(1216-1218)gaG>gaA	p.E406E	HSPA1L_ENST00000417199.3_Silent_p.E406E	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	406					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						CCCCAGCCGTCTCCAGCCCCA	0.607000													22	108					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271762	22271762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22271762G>A	ENST00000594947.1	+	4	1354	c.1210G>A	c.(1210-1212)Gaa>Aaa	p.E404K		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				CAAATGTGATGAATATTGCAA	0.393000													16	25					0	0	1	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18067213	18067213	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18067213C>T	ENST00000506618.2	-	1	273	c.193G>A	c.(193-195)Gac>Aac	p.D65N		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	65					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					ATTAGACTGTCGTTGATTTCG	0.478000													120	286					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24344800	24344800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24344800C>T	ENST00000175238.6	+	11	1144	c.1061C>T	c.(1060-1062)tCa>tTa	p.S354L	ADAM7_ENST00000520720.1_Missense_Mutation_p.S126L|RP11-624C23.1_ENST00000523578.1_RNA|ADAM7_ENST00000380789.1_Missense_Mutation_p.S354L|RP11-624C23.1_ENST00000519689.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	354	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ACCTGTCCTTCAGGAAAATGC	0.458000													16	28					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116960807	116960807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:116960807C>T	ENST00000265441.3	-	2	423	c.124G>A	c.(124-126)Gat>Aat	p.D42N	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	42					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		GGCACATTATCGCACATCACC	0.592000													3	23					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88478074	88478074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:88478074G>A	ENST00000267549.3	+	2	1441	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	295					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TTTTGTAACCGAAACAGGAAG	0.353000													10	55					0	0	1	0	0
SOCS5	9655	broad.mit.edu	37	2	46986807	46986807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:46986807C>T	ENST00000306503.5	+	2	1310	c.1138C>T	c.(1138-1140)Ccc>Tcc	p.P380S	SOCS5_ENST00000394861.2_Missense_Mutation_p.P380S	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	380					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TACAGGGAATCCCTGTTACTG	0.498000													17	50					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28659848	28659848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28659848C>T	ENST00000280904.6	-	11	2071	c.1628G>A	c.(1627-1629)gGc>gAc	p.G543D	DSC2_ENST00000251081.6_Missense_Mutation_p.G543D	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	543	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			ATTATATATGCCATTTTTGAT	0.388000													65	161					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622674	38622674	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38622674G>A	ENST00000413689.1	-	17	3169	c.2976C>T	c.(2974-2976)ccC>ccT	p.P992P	SCN5A_ENST00000423572.2_Silent_p.P992P|SCN5A_ENST00000425664.1_Silent_p.P992P|SCN5A_ENST00000455624.2_Silent_p.P992P|SCN5A_ENST00000450102.2_Silent_p.P992P|SCN5A_ENST00000449557.2_Silent_p.P992P|SCN5A_ENST00000414099.2_Silent_p.P992P|SCN5A_ENST00000451551.2_Silent_p.P992P|SCN5A_ENST00000333535.4_Silent_p.P992P|SCN5A_ENST00000443581.1_Silent_p.P992P	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	992					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CAAGGGCTGCGGGCTTCTGAG	0.687000													6	14					0	0	1	0	0
WNT5A	7474	broad.mit.edu	37	3	55504230	55504230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:55504230C>T	ENST00000474267.1	-	6	1554	c.1033G>A	c.(1033-1035)Gac>Aac	p.D345N	WNT5A_ENST00000264634.4_Missense_Mutation_p.D345N|WNT5A_ENST00000497027.1_Missense_Mutation_p.D330N			P41221	WNT5A_HUMAN	wingless-type MMTV integration site family, member 5A	345					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(1)|large_intestine(4)|lung(3)|prostate(2)|urinary_tract(1)	13				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		TTGAACTGGTCGTAGCCACGG	0.617000													25	81					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	128829926	128829926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:128829926C>T	ENST00000280333.6	+	17	1683	c.1574C>T	c.(1573-1575)tCt>tTt	p.S525F		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	525	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		AAGGATAAATCTGAGAAAATA	0.348000													34	83					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934796	113934796	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113934796G>A	ENST00000335953.4	+	2	1154	c.774G>A	c.(772-774)ggG>ggA	p.G258G	ZBTB16_ENST00000392996.2_Silent_p.G258G	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	258					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		ACAGCCCTGGGGCAGCCGAGT	0.647000													15	18					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46989702	46989702	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46989702C>T	ENST00000371253.2	-	6	759	c.544G>A	c.(544-546)Gaa>Aaa	p.E182K	GPR110_ENST00000371243.2_Missense_Mutation_p.E182K|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	182	SEA.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						ACTTGAATTTCAATTCCATTT	0.294000													30	69					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876232	35876232	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35876232G>A	ENST00000303115.3	+	8	1153	c.1024G>A	c.(1024-1026)Ggg>Agg	p.G342R	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	342					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GAGGCTTGGAGGGGATGTGCA	0.488000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						17	41					0	0	1	0	0
CSN1S1	1446	broad.mit.edu	37	4	70810643	70810643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70810643C>T	ENST00000246891.4	+	15	527	c.478C>T	c.(478-480)Cct>Tct	p.P160S	CSN1S1_ENST00000505782.1_Missense_Mutation_p.P144S|CSN1S1_ENST00000507763.1_Missense_Mutation_p.P151S|CSN1S1_ENST00000507772.1_Missense_Mutation_p.P152S|CSN1S1_ENST00000444405.3_Missense_Mutation_p.P151S	NM_001890.1	NP_001881.1	P47710	CASA1_HUMAN	casein alpha s1	160						extracellular region	protein binding|transporter activity			lung(5)|prostate(1)|upper_aerodigestive_tract(1)	7						GCAGTATGTTCCTTTCCCACC	0.408000													84	226					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783315	54783315	+	Silent	SNP	G	G	A	rs143879306	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54783315G>A	ENST00000391748.1	-	5	670	c.543C>T	c.(541-543)ttC>ttT	p.F181F	LILRB2_ENST00000434421.1_Silent_p.F65F|LILRB2_ENST00000391746.1_Silent_p.F181F|LILRB2_ENST00000314446.5_Silent_p.F181F|LILRB2_ENST00000391749.4_Silent_p.F181F	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	181	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGCCCACGGAGAAGATGGCGC	0.577000													23	127					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124393810	124393810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124393810C>T	ENST00000409039.3	+	57	9489	c.9464C>T	c.(9463-9465)tCg>tTg	p.S3155L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3155	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTTGCCAGGTCGTTTGCTAAG	0.542000													13	18					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103143635	103143635	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103143635G>A	ENST00000428762.1	-	52	8476	c.8317C>T	c.(8317-8319)Caa>Taa	p.Q2773*	CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000343529.5_Nonsense_Mutation_p.Q2773*|RELN_ENST00000424685.2_Nonsense_Mutation_p.Q2773*	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2773					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACATGAATTTGATTCTGGGCA	0.383000													9	91					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49866927	49866927	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49866927G>A	ENST00000331456.2	-	14	1364	c.1251C>T	c.(1249-1251)ttC>ttT	p.F417F	TRAIP_ENST00000469027.1_Silent_p.F262F	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	417	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CGAGCCCATCGAAGCCTGTCC	0.562000													20	50					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71730343	71730343	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71730343G>A	ENST00000258104.3	+	4	513		c.e4-1		DYSF_ENST00000394120.2_Splice_Site|DYSF_ENST00000409744.1_Splice_Site|DYSF_ENST00000410020.3_Splice_Site|DYSF_ENST00000413539.2_Splice_Site|DYSF_ENST00000429174.2_Splice_Site|DYSF_ENST00000409366.1_Splice_Site|DYSF_ENST00000409582.3_Splice_Site|DYSF_ENST00000409762.1_Splice_Site|DYSF_ENST00000409651.1_Splice_Site|DYSF_ENST00000410041.1_Splice_Site	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin							cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TCTCCTCTCAGGTTCCTGGGG	0.597000													63	168					0	0	1	0	0
MCM5	4174	broad.mit.edu	37	22	35813759	35813759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:35813759C>T	ENST00000216122.4	+	13	1767	c.1613C>T	c.(1612-1614)aCt>aTt	p.T538I	MCM5_ENST00000382011.5_Missense_Mutation_p.T495I	NM_006739.3	NP_006730.2	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	538					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29						CATGTCATCACTCTGCACGTG	0.577000													51	106					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77288529	77288529	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77288529C>T	ENST00000388914.3	-	11	1900	c.1748G>A	c.(1747-1749)cGa>cAa	p.R583Q		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	583								p.R583Q(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						TCCAGCAGTTCGTCCATGCTG	0.458000													33	76					0	0	1	0	0
CHST6	4166	broad.mit.edu	37	16	75513171	75513171	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:75513171G>A	ENST00000332272.4	-	3	735	c.556C>T	c.(556-558)Ccg>Tcg	p.P186S	RP11-77K12.4_ENST00000530512.3_RNA|CHST6_ENST00000390664.2_Missense_Mutation_p.P186S	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	186					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CTGAGCAGCGGGTAGAGCACC	0.701000													21	66					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87392992	87392992	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:87392992C>T	ENST00000517970.1	+	4	415	c.108C>T	c.(106-108)ttC>ttT	p.F36F	WWP1_ENST00000523863.1_3'UTR|WWP1_ENST00000349423.2_Intron|WWP1_ENST00000341922.2_Silent_p.F36F|WWP1_ENST00000265428.4_Silent_p.F36F	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	36	C2.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						AGAACTGGTTCGGAACAGCAA	0.348000													9	38					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655992	19655992	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19655992C>T	ENST00000586018.1	+	8	2758	c.2656C>T	c.(2656-2658)Ccg>Tcg	p.P886S	CILP2_ENST00000291495.4_Missense_Mutation_p.P880S			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	880						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GCCTGTGTACCCGTGGCGCAG	0.677000													19	35					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118997858	118997858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:118997858C>T	ENST00000328252.3	+	7	3043	c.2674C>T	c.(2674-2676)Cct>Tct	p.P892S	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	892					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GGTCCGGGACCCTCCTCTCCA	0.507000													10	94					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131923622	131923622	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131923622C>T	ENST00000378823.3	+	7	1293	c.475C>T	c.(475-477)Caa>Taa	p.Q159*	RAD50_ENST00000265335.6_Nonsense_Mutation_p.Q298*|RAD50_ENST00000487596.1_3'UTR	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	298					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACAGGTTTTTCAAGGGACTGA	0.323000								Homologous recombination					25	55					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25785868	25785868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25785868C>T	ENST00000399878.3	-	14	2384	c.2262G>A	c.(2260-2262)atG>atA	p.M754I	SEL1L3_ENST00000264868.5_Missense_Mutation_p.M719I|SEL1L3_ENST00000502949.1_Missense_Mutation_p.M601I	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	754						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						CTGCTTTCTTCATCAGCTCTA	0.443000													80	145					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86249817	86249817	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86249817G>A	ENST00000370571.2	-	50	4566	c.4200C>T	c.(4198-4200)ttC>ttT	p.F1400F	COL24A1_ENST00000436319.1_Silent_p.F1400F	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1400	Collagen-like 16.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GGAATCCTTGGAAACCTGTCA	0.358000													28	76					0	0	1	0	0
ARRDC5	645432	broad.mit.edu	37	19	4896717	4896717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4896717C>T	ENST00000381781.2	-	2	466	c.467G>A	c.(466-468)gGa>gAa	p.G156E		NM_001080523.1	NP_001073992.1	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	156					signal transduction					endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		GGTGGAAGTTCCTTGAACCAA	0.488000													20	38					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486995	125486995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125486995G>A	ENST00000259466.1	+	1	727	c.727G>A	c.(727-729)Ggc>Agc	p.G243S		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						CTCTACCTGTGGCTCCCACCT	0.537000													33	148					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704941	52704941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:52704941C>T	ENST00000287727.3	+	4	2024	c.1852C>T	c.(1852-1854)Ctt>Ttt	p.L618F	ZFYVE9_ENST00000357206.2_Missense_Mutation_p.L618F|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.L618F|ZFYVE9_ENST00000361625.1_Missense_Mutation_p.L618F	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	618					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AAATGATATTCTTGGGAAAGC	0.328000													12	117					0	0	1	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87445462	87445462	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:87445462G>A	ENST00000268616.4	-	12	2671	c.2454C>T	c.(2452-2454)tcC>tcT	p.S818S		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	818					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		AGGTGAACACGGACGGACCGG	0.652000													3	11					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118596651	118596651	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:118596651G>A	ENST00000336338.5	-	20	2853	c.2788C>T	c.(2788-2790)Cct>Tct	p.P930S		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	930						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AAAATGAAAGGAATCTTTTCC	0.313000													6	36					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323399	79323399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79323399G>A	ENST00000428286.1	-	8	3914	c.2714C>T	c.(2713-2715)tCc>tTc	p.S905F	PRUNE2_ENST00000376718.3_Missense_Mutation_p.S1264F			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1264					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CGCATCTGGGGAATGAGTGTC	0.478000													16	29					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141773915	141773915	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141773915C>T	ENST00000475668.2	+	45	5271	c.5217C>T	c.(5215-5217)gcC>gcT	p.A1739A	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1739	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTATTATTGCCCTAGATGAAA	0.433000													13	39					0	0	1	0	0
IFLTD1	160492	broad.mit.edu	37	12	25702421	25702421	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25702421G>A	ENST00000282881.6	-	2	235	c.86C>T	c.(85-87)tCa>tTa	p.S29L	IFLTD1_ENST00000445693.1_Intron|IFLTD1_ENST00000413632.2_Missense_Mutation_p.S50L|IFLTD1_ENST00000458174.2_Missense_Mutation_p.S50L|IFLTD1_ENST00000539744.1_5'UTR	NM_152590.3	NP_689803.2	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	29						intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	22	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TGTGGCAACTGAACCCAACAT	0.333000													25	94					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104164482	104164482	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104164482C>T	ENST00000020673.5	-	15	3084	c.2558G>A	c.(2557-2559)aGc>aAc	p.S853N	PSD_ENST00000406432.1_Missense_Mutation_p.S853N	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	853	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CTGCTCCAGGCTCCTGGGGAG	0.557000													33	126					0	0	1	0	0
TTLL9	164395	broad.mit.edu	37	20	30507699	30507699	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30507699C>T	ENST00000375938.4	+	7	790	c.537C>T	c.(535-537)ctC>ctT	p.L179L	TTLL9_ENST00000310998.4_Silent_p.L129L|TTLL9_ENST00000535842.1_Silent_p.L179L|TTLL9_ENST00000375934.4_Silent_p.L161L|TTLL9_ENST00000375922.4_Intron|TTLL9_ENST00000375921.2_Intron			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	179	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GCATCTTCCTCTTCCGTAGGC	0.622000													35	62					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38484966	38484966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38484966C>T	ENST00000263409.4	-	18	2664	c.2502G>A	c.(2500-2502)gtG>gtA	p.V834V	LIFR_ENST00000453190.2_Silent_p.V834V	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	834					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TAATTAATCCCACAGCTGAAA	0.368000			T	PLAG1	salivary adenoma								7	35					0	0	1	0	0
SFTPD	6441	broad.mit.edu	37	10	81702197	81702197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81702197C>T	ENST00000372292.3	-	4	420	c.380G>A	c.(379-381)gGg>gAg	p.G127E		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	127	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TCCTATGTTCCCCTGCTTCCC	0.592000													17	41					0	0	1	0	0
SPOPL	339745	broad.mit.edu	37	2	139326544	139326544	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:139326544C>T	ENST00000280098.4	+	11	1452	c.1073C>T	c.(1072-1074)tCc>tTc	p.S358F		NM_001001664.2	NP_001001664.1	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	358						nucleus				breast(2)|cervix(2)|endometrium(2)|large_intestine(2)|lung(11)|skin(2)	21				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GGGTGGAAGTCCATGATTCAG	0.408000													102	267					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52536041	52536041	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52536041G>A	ENST00000321725.6	+	4	427	c.351G>A	c.(349-351)gaG>gaA	p.E117E		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	117	EGF-like 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGGGCGCTGAGACCCCATGCA	0.637000													14	43					0	0	1	0	0
COL9A2	1298	broad.mit.edu	37	1	40768415	40768415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40768415G>A	ENST00000372748.3	-	30	1766	c.1670C>T	c.(1669-1671)cCt>cTt	p.P557L	COL9A2_ENST00000466267.1_5'UTR	NM_001852.3	NP_001843.1	Q14055	CO9A2_HUMAN	collagen, type IX, alpha 2	557	Triple-helical region 2 (COL2).				axon guidance|skeletal system development	collagen type IX				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(4)|stomach(2)|urinary_tract(2)	22	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			AGGTCCTGGAGGACCCATCAT	0.701000													4	9					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82625885	82625885	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:82625885C>T	ENST00000533655.1	+	3	317	c.105C>T	c.(103-105)gtC>gtT	p.V35V	C11orf82_ENST00000329143.3_5'UTR|C11orf82_ENST00000430323.2_Silent_p.V35V|C11orf82_ENST00000525361.1_Silent_p.V35V|C11orf82_ENST00000525388.1_Silent_p.V35V|C11orf82_ENST00000528759.1_Silent_p.V35V|C11orf82_ENST00000524921.1_Silent_p.V35V	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	35					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TAATCCTGGTCTCCAAAAGGT	0.393000													13	39					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41725620	41725620	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41725620C>T	ENST00000400454.1	-	5	1183	c.706G>A	c.(706-708)Gcc>Acc	p.A236T		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	236	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCAGCCATGGCTTTGCGATGG	0.547000													14	22					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124596525	124596525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124596525G>A	ENST00000368904.1	-	7	1588	c.639C>T	c.(637-639)gcC>gcT	p.A213A	CUZD1_ENST00000545804.1_Silent_p.A213A|CUZD1_ENST00000392790.1_Silent_p.A213A			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	213	CUB 2.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		CATCATAGATGGCAAGAAAAT	0.443000													17	46					0	0	1	0	0
PDGFC	56034	broad.mit.edu	37	4	157771398	157771398	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:157771398C>T	ENST00000502773.1	-	2	779	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K	PDGFC_ENST00000541126.1_Intron|PDGFC_ENST00000542208.1_5'UTR|PDGFC_ENST00000422544.2_Missense_Mutation_p.E97K	NM_016205.2	NP_057289.1	Q9NRA1	PDGFC_HUMAN	platelet derived growth factor C	97	CUB.				central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		TCTGGGTCTTCAAGCCCAAAT	0.348000													19	57					0	0	1	0	0
ADAM32	203102	broad.mit.edu	37	8	39089647	39089647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39089647G>A	ENST00000379907.4	+	15	1754	c.1627G>A	c.(1627-1629)Gga>Aga	p.G543R	ADAM32_ENST00000437682.2_Missense_Mutation_p.G444R|ADAM32_ENST00000519315.1_Missense_Mutation_p.G437R	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	543					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGTGTTCTGTGGATGGAGGTA	0.338000													15	73					0	0	1	0	0
LIPJ	142910	broad.mit.edu	37	10	90356112	90356112	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:90356112C>T	ENST00000371939.3	+	7	829	c.515C>T	c.(514-516)tCc>tTc	p.S172F		NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J	172					lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		CCAGTTTTTTCCACAAAGTAC	0.254000													15	37					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131976248	131976248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131976248G>A	ENST00000356920.5	+	1	367	c.273G>A	c.(271-273)atG>atA	p.M91I	POTEE_ENST00000358087.5_Missense_Mutation_p.M91I|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	91							ATP binding										ACTCTGCTATGAAGACACTCA	0.617000													18	83					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186115002	186115002	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:186115002C>T	ENST00000271588.4	+	93	14784	c.14555C>T	c.(14554-14556)cCc>cTc	p.P4852L	HMCN1_ENST00000367492.2_Missense_Mutation_p.P4852L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4852	TSP type-1 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GGTGGCCGTCCCTGTCCCGGA	0.537000													16	63					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97045391	97045391	+	Nonsense_Mutation	SNP	G	G	A	rs78760556		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:97045391G>A	ENST00000524981.3	+	3	251	c.251G>A	c.(250-252)tGg>tAg	p.W84*				Q6ZTY8	CL063_HUMAN		58										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GGTGGCTATTGGACTCTGCTT	0.383000													49	73					0	0	1	0	0
ACTC1	70	broad.mit.edu	37	15	35084718	35084718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:35084718C>T	ENST00000290378.4	-	4	1162	c.507G>A	c.(505-507)gaG>gaA	p.E169E	RP11-814P5.1_ENST00000503496.1_RNA|ACTC1_ENST00000557860.1_5'UTR	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	169					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AAGCGTAGCCCTCATAGATGG	0.532000													11	86					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94129588	94129588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:94129588C>T	ENST00000243673.2	-	2	661	c.490G>A	c.(490-492)Gcc>Acc	p.A164T	GPR83_ENST00000539203.2_Intron	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	164						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ACCGCAATGGCTGTCAGTGTC	0.557000													20	50					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60703555	60703555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60703555C>T	ENST00000005286.4	+	11	2404	c.2251C>T	c.(2251-2253)Cgg>Tgg	p.R751W	TMEM132A_ENST00000453848.2_Missense_Mutation_p.R750W	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	750	Binds to HSPA5/GRP78 (By similarity).|Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GCCCTGCCGCCGGGGCCGCCA	0.746000													4	22					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29429491	29429491	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29429491G>A	ENST00000377136.1	+	0	410				OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000377133.1_De_novo_Start_OutOfFrame|OR2H1_ENST00000442615.1_De_novo_Start_OutOfFrame|OR2H1_ENST00000396792.2_De_novo_Start_OutOfFrame|OR2H1_ENST00000377132.1_De_novo_Start_OutOfFrame			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						GATAAGACAGGTTGAATCACA	0.527000													19	45					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171482205	171482205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171482205C>T	ENST00000367742.3	+	3	426	c.184C>T	c.(184-186)Ctc>Ttc	p.L62F	PRRC2C_ENST00000476522.1_3'UTR|PRRC2C_ENST00000426496.2_Missense_Mutation_p.L60F|PRRC2C_ENST00000338920.4_Missense_Mutation_p.L60F|PRRC2C_ENST00000392078.3_Missense_Mutation_p.L62F			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	60							protein C-terminus binding										ACCTGCTAACCTCCCAAGTCT	0.418000													12	49					0	0	1	0	0
GTPBP4	23560	broad.mit.edu	37	10	1046704	1046704	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:1046704C>T	ENST00000360803.4	+	7	824	c.742C>T	c.(742-744)Cgt>Tgt	p.R248C	GTPBP4_ENST00000545048.1_Missense_Mutation_p.R201C|GTPBP4_ENST00000538293.1_Missense_Mutation_p.R132C|GTPBP4_ENST00000491635.1_3'UTR	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	248					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		GGCCCACCTCCGTGCTGCGGT	0.557000													38	71					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66931444	66931444	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:66931444G>A	ENST00000374690.3	+	4	2610	c.2086G>A	c.(2086-2088)Gac>Aac	p.D696N	AR_ENST00000396043.2_Missense_Mutation_p.D164N|AR_ENST00000396044.3_Missense_Mutation_p.D696N	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	695	Interaction with MYST2.|Ligand-binding.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CAACCAGCCCGACTCCTTTGC	0.527000									Androgen Insensitivity Syndrome				9	24					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70922888	70922888	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70922888C>T	ENST00000264436.3	-	6	964	c.520G>A	c.(520-522)Gga>Aga	p.G174R	ADD2_ENST00000407644.2_Missense_Mutation_p.G174R|ADD2_ENST00000430656.1_Missense_Mutation_p.G190R|ADD2_ENST00000355733.3_Missense_Mutation_p.G174R|ADD2_ENST00000413157.2_Missense_Mutation_p.G174R	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	174					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding	p.G174R(2)		autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CAAGAAACTCCCTTAGGGCTG	0.517000													8	31					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43976494	43976494	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43976494G>A	ENST00000262726.7	-	25	3331	c.3078C>T	c.(3076-3078)ttC>ttT	p.F1026F	EFCAB6_ENST00000396231.2_Silent_p.F874F	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1026					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CTGCTCTCAGGAAGTCGAGGT	0.458000													107	267					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086479	100086479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100086479G>A	ENST00000423930.1	+	4	1294	c.1135G>A	c.(1135-1137)Gag>Aag	p.E379K	NYAP1_ENST00000300179.2_Missense_Mutation_p.E379K|NYAP1_ENST00000454988.1_Missense_Mutation_p.E322K			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	379	Pro-rich.																GCCTGCACGGGAGCGGGAGAC	0.701000													24	50					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55958861	55958861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55958861C>T	ENST00000263923.4	-	22	3287	c.2992G>A	c.(2992-2994)Gac>Aac	p.D998N		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	998	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTCAGGAAGTCCTTATACAGA	0.448000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			15	52					0	0	1	0	0
OR1I1	126370	broad.mit.edu	37	19	15198724	15198724	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15198724C>T	ENST00000209540.2	+	1	934	c.848C>T	c.(847-849)cCc>cTc	p.P283L		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						GTGTTCATCCCCATGCTCAAC	0.562000													14	73					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47332457	47332457	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47332457G>A	ENST00000398879.1	-	26	4185	c.3819C>T	c.(3817-3819)gcC>gcT	p.A1273A	TNS3_ENST00000311160.9_Silent_p.A1273A|TNS3_ENST00000355730.3_Silent_p.A1033A			Q68CZ2	TENS3_HUMAN	tensin 3	1273	SH2.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TGCACGGCAAGGCCAAGGGCG	0.537000													16	59					0	0	1	0	0
IGFL2	147920	broad.mit.edu	37	19	46663672	46663672	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46663672C>T	ENST00000434646.2	+	3	344	c.52_splice	c.e3-1	p.A18_splice	IGFL2_ENST00000600243.1_3'UTR|AC007193.6_ENST00000597989.1_lincRNA|IGFL2_ENST00000377693.4_Splice_Site_p.A7_splice	NM_001002915.2	NP_001002915.2	Q6UWQ7	IGFL2_HUMAN	IGF-like family member 2	7						extracellular region	protein binding			cervix(1)|lung(5)	6		Ovarian(192;0.0908)|all_neural(266;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(486;0.031)|Epithelial(262;0.247)		TCTCTCCCAGCTCCTGCTTAT	0.542000													5	18					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45946460	45946460	+	Silent	SNP	C	C	T	rs138534271	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45946460C>T	ENST00000348697.2	+	14	1809	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F	FBLN1_ENST00000476366.1_3'UTR|FBLN1_ENST00000340923.5_Silent_p.F554F|FBLN1_ENST00000402984.3_Silent_p.F592F|FBLN1_ENST00000442170.2_Silent_p.F554F|FBLN1_ENST00000327858.6_Silent_p.F554F|FBLN1_ENST00000262722.7_Silent_p.F554F			P23142	FBLN1_HUMAN	fibulin 1	554	EGF-like 9; calcium-binding.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GCCTGGCCTTCGAGTGCCCTG	0.592000													12	80					0	0	1	0	0
UBA1	7317	broad.mit.edu	37	X	47060944	47060944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:47060944C>T	ENST00000335972.6	+	8	929	c.746C>T	c.(745-747)tCc>tTc	p.S249F	UBA1_ENST00000377351.4_Missense_Mutation_p.S249F	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	249	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GACTTTGTCTCCTTTTCAGAA	0.547000													28	12					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20506951	20506951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20506951G>A	ENST00000202677.6	-	28	3780	c.3638C>T	c.(3637-3639)tCc>tTc	p.S1213F		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	1213					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						CTCCCAGTAGGAAACCAGCAA	0.408000													4	36					0	0	1	0	0
C9orf9	11092	broad.mit.edu	37	9	135759460	135759460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135759460C>T	ENST00000372136.3	+	2	573	c.126C>T	c.(124-126)ccC>ccT	p.P42P	C9orf9_ENST00000356311.5_Silent_p.P42P|C9orf9_ENST00000350499.6_Silent_p.P42P			Q96E40	CI009_HUMAN	chromosome 9 open reading frame 9	42								p.?(1)		cervix(1)|large_intestine(1)|lung(1)|prostate(1)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|GBM - Glioblastoma multiforme(294;4.84e-07)|Epithelial(140;1.28e-06)		AGATCCGGCCCATCTCCAGCA	0.632000													7	53					0	0	1	0	0
MRPS31	10240	broad.mit.edu	37	13	41331094	41331094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:41331094G>A	ENST00000323563.6	-	4	691	c.655C>T	c.(655-657)Cgt>Tgt	p.R219C		NM_005830.3	NP_005821.2	Q92665	RT31_HUMAN	mitochondrial ribosomal protein S31	219						mitochondrion|ribosome	protein domain specific binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	13		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)		GGTCTTGAACGAACTCTAGCT	0.373000													26	77					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156815774	156815774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156815774C>T	ENST00000368195.3	-	9	2344	c.1948G>A	c.(1948-1950)Gac>Aac	p.D650N	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	650	Fibronectin type-III 2.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGGTAGAGGTCGCCGTCCTCT	0.706000													15	26					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656465	19656465	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19656465G>A	ENST00000586018.1	+	8	3231	c.3129G>A	c.(3127-3129)ccG>ccA	p.P1043P	CILP2_ENST00000291495.4_Silent_p.P1037P			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	1037						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						ACCCCCCACCGGTGCCCGCGG	0.667000													5	16					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63005497	63005497	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:63005497G>A	ENST00000251157.5	-	26	3145	c.3112C>T	c.(3112-3114)Cca>Tca	p.P1038S	DOCK7_ENST00000340370.5_Missense_Mutation_p.P1007S	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1038					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						AAACGTTCTGGAAAACGACTT	0.348000													25	45					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54951462	54951462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54951462C>T	ENST00000173898.7	+	6	1558	c.1446C>T	c.(1444-1446)ttC>ttT	p.F482F	TRO_ENST00000319167.8_Silent_p.F482F|TRO_ENST00000420798.2_Silent_p.F13F|TRO_ENST00000375041.2_Silent_p.F85F|TRO_ENST00000484031.1_3'UTR|TRO_ENST00000399736.1_Silent_p.F85F|TRO_ENST00000375022.4_Silent_p.F482F	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	482	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						ATGAATATTTCCCAGAAATCA	0.502000													15	10					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154105	5154105	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5154105C>T	ENST00000252321.3	+	1	1021	c.792C>T	c.(790-792)atC>atT	p.I264I		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	264						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TCATCTCCATCATCACCTTCT	0.647000													20	147					0	0	1	0	0
EIF2AK2	5610	broad.mit.edu	37	2	37366820	37366820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37366820G>A	ENST00000233057.4	-	6	792	c.470C>T	c.(469-471)gCc>gTc	p.A157V	EIF2AK2_ENST00000395127.2_Missense_Mutation_p.A157V|EIF2AK2_ENST00000405334.1_Missense_Mutation_p.A157V	NM_001135651.2	NP_001129123.1	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 2	157	DRBM 2.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)	22		all_hematologic(82;0.248)				AAGTTTAGCGGCCAATTGTTT	0.333000													38	127					0	0	1	0	0
MYL3	4634	broad.mit.edu	37	3	46899877	46899877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46899877C>T	ENST00000395869.1	-	5	607	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K	MYL3_ENST00000292327.4_Missense_Mutation_p.E186K			P08590	MYL3_HUMAN	myosin, light chain 3, alkali; ventricular, skeletal, slow	186	EF-hand 3.				cardiac muscle contraction|muscle filament sliding|positive regulation of ATPase activity|regulation of striated muscle contraction|regulation of the force of heart contraction|ventricular cardiac muscle tissue morphogenesis	A band|cytosol|I band|muscle myosin complex	actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			breast(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(193;0.00116)|KIRC - Kidney renal clear cell carcinoma(197;0.00557)|Kidney(197;0.0063)		AGCCCACCTTCATAGTTGATG	0.602000													15	62					0	0	1	0	0
ERP27	121506	broad.mit.edu	37	12	15090909	15090909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15090909C>T	ENST00000266397.2	-	2	745	c.172G>A	c.(172-174)Gtg>Atg	p.V58M		NM_152321.2	NP_689534.1	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27	58	Thioredoxin.					endoplasmic reticulum lumen				breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(3)|prostate(2)|skin(1)	19						ATGACAGCCACCTCAGTGGCA	0.532000													33	143					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99566032	99566032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99566032C>T	ENST00000411734.1	-	3	355	c.350G>A	c.(349-351)aGg>aAg	p.R117K	AZGP1_ENST00000292401.4_Missense_Mutation_p.R120K			P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	120					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					ACAACCAAACCTTCCCTGCAA	0.433000													40	410					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885902	24885902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24885902C>T	ENST00000382554.3	+	9	5265	c.4947C>T	c.(4945-4947)ttC>ttT	p.F1649F		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1649	Integrase catalytic.				DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TGGAGGCATTCCCCCTGAAGC	0.602000													12	49					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26514727	26514727	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26514727G>A	ENST00000531191.1	+	16	1690	c.683G>A	c.(682-684)tGg>tAg	p.W228*	CNKSR1_ENST00000361530.6_Nonsense_Mutation_p.W486*|CNKSR1_ENST00000374253.5_Nonsense_Mutation_p.W493*			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	493	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging	p.W486*(1)		breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCATAGGTGGGTGCGTCAT	0.572000													24	34					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182555890	182555890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:182555890C>T	ENST00000367559.3	-	2	305	c.52G>A	c.(52-54)Ggt>Agt	p.G18S	RNASEL_ENST00000539397.1_Missense_Mutation_p.G18S|RNASEL_ENST00000444138.1_Missense_Mutation_p.G18S	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	18					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						GCCCTTCTACCGCTGGAGGAC	0.498000													17	149					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26093564	26093564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26093564G>A	ENST00000313735.6	-	19	2451	c.2218C>T	c.(2218-2220)Cgg>Tgg	p.R740W		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	740	FAD-binding FR-type.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGATTCTGCCGAGATTTGAGC	0.478000													29	101					0	0	1	0	0
CFHR2	3080	broad.mit.edu	37	1	196918671	196918671	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196918671G>A	ENST00000367415.4	+	2	259	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	CFHR2_ENST00000476712.1_3'UTR|CFHR2_ENST00000367421.3_Missense_Mutation_p.E49K	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	49	Sushi 1.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						TCCTACAGGGGAAGTTTTCTA	0.363000													27	58					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142612675	142612675	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142612675C>T	ENST00000265310.1	-	9	1534	c.1186G>A	c.(1186-1188)Gct>Act	p.A396T		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	396					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					ATGATCACAGCCCCAACGATG	0.537000													9	41					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14613922	14613922	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14613922C>T	ENST00000544627.1	+	9	2996	c.2676C>T	c.(2674-2676)gcC>gcT	p.A892A	ATF7IP_ENST00000536444.1_Silent_p.A883A|ATF7IP_ENST00000543189.1_Silent_p.A883A|ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000540793.1_Silent_p.A884A|ATF7IP_ENST00000261168.4_Silent_p.A884A			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	884					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TTGTACAAGCCACAAGGACTT	0.458000													7	32					0	0	1	0	0
CLEC2L	154790	broad.mit.edu	37	7	139225185	139225185	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139225185C>T	ENST00000422142.2	+	3	456	c.384C>T	c.(382-384)tgC>tgT	p.C128C		NM_001080511.2	NP_001073980.2	P0C7M8	CLC2L_HUMAN	C-type lectin domain family 2, member L	128	C-type lectin.					integral to membrane	sugar binding			NS(1)|endometrium(1)|kidney(2)|lung(1)	5	Melanoma(164;0.233)					GGCAGTACTGCCACACCCACG	0.622000													10	6					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255045	15255045	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15255045C>T	ENST00000378116.4	-	8	2548	c.2542G>A	c.(2542-2544)Gcc>Acc	p.A848T		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	848						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TGGGGGCTGGCTGCTGGCTCC	0.607000													69	130					0	0	1	0	0
PSMC3	5702	broad.mit.edu	37	11	47447451	47447451	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47447451G>A	ENST00000298852.3	-	2	283	c.126C>T	c.(124-126)atC>atT	p.I42I	PSMC3_ENST00000602866.1_Silent_p.I26I|PSMC3_ENST00000530912.1_Silent_p.I42I	NM_002804.4	NP_002795.2	P17980	PRS6A_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 3	42					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(4)|urinary_tract(1)	17				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GTGTGCGCTGGATGATCTCCT	0.532000													27	69					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862824	10862824	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10862824C>T	ENST00000559480.1	+	0	120																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						TGAAGGTCTCCTGCAAGGCTT	0.577000													27	177					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106215	55106215	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55106215C>T	ENST00000453777.1	+	4	326	c.156C>T	c.(154-156)atC>atT	p.I52I	LILRA1_ENST00000251372.3_Silent_p.I52I|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	52	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GTCAGGGGATCCTGGAGACCC	0.577000													36	101					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120584894	120584894	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120584894G>A	ENST00000300648.6	-	38	4921	c.4909C>T	c.(4909-4911)Cag>Tag	p.Q1637*		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1637					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAATAATCTGGGCTGCCATC	0.552000													4	30					0	0	1	0	0
INPP5J	27124	broad.mit.edu	37	22	31521797	31521797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31521797C>T	ENST00000331075.5	+	2	1121	c.1072C>T	c.(1072-1074)Cgc>Tgc	p.R358C	INPP5J_ENST00000400294.2_Intron|INPP5J_ENST00000405300.1_Intron|INPP5J_ENST00000412277.2_Missense_Mutation_p.R291C|INPP5J_ENST00000404390.3_Intron			Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J	358	Pro-rich.					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	12						CTCCCCGAATCGCTCTCCCTG	0.687000													4	10					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154684136	154684136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:154684136G>A	ENST00000404039.1	+	26	2939	c.2352G>A	c.(2350-2352)agG>agA	p.R784R	DPP6_ENST00000332007.3_Silent_p.R786R|DPP6_ENST00000427557.1_Silent_p.R741R|DPP6_ENST00000377770.3_Silent_p.R848R	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	848					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AATGCTTCAGGATCCAGGACA	0.502000													51	99					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124810354	124810354	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124810354G>A	ENST00000423114.2	-	12	1936	c.1937C>T	c.(1936-1938)aCc>aTc	p.T646I	SLC12A8_ENST00000469902.1_Missense_Mutation_p.T617I|SLC12A8_ENST00000314584.7_Intron|SLC12A8_ENST00000430155.2_Missense_Mutation_p.T418I|SLC12A8_ENST00000465475.1_Intron|SLC12A8_ENST00000393469.4_Missense_Mutation_p.T617I			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	617					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						GTTAACCAGGGTATACACCCA	0.488000													21	52					0	0	1	0	0
SRMS	6725	broad.mit.edu	37	20	62178550	62178550	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62178550G>A	ENST00000217188.1	-	1	307	c.267C>T	c.(265-267)ttC>ttT	p.F89F		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	89	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GCCTGCGTGCGAAGATGTAGC	0.672000													14	41					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4873157	4873157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4873157G>A	ENST00000252318.2	+	9	1874	c.1537G>A	c.(1537-1539)Gga>Aga	p.G513R		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	513	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CTTGGATCAGGGACCCGTTCC	0.502000													42	85					0	0	1	0	0
IGKV1-6	28943	broad.mit.edu	37	2	89265922	89265922	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89265922G>A	ENST00000464162.1	-	0	238																											ATGCAGCATAGATCAGGAGCT	0.517000													104	198					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984913	41984913	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41984913C>T	ENST00000333141.5	+	1	1201	c.1104C>T	c.(1102-1104)ttC>ttT	p.F368F		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	368										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						GCGTGGCCTTCGCTTCTCGGC	0.607000													33	50					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129207226	129207226	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129207226G>A	ENST00000296266.3	+	17	2323	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K	IFT122_ENST00000347300.2_Missense_Mutation_p.E601K|IFT122_ENST00000431818.2_Missense_Mutation_p.E510K|IFT122_ENST00000349441.2_Missense_Mutation_p.E549K|IFT122_ENST00000440957.2_Missense_Mutation_p.E451K|IFT122_ENST00000348417.2_Missense_Mutation_p.E660K|IFT122_ENST00000507564.1_Missense_Mutation_p.E652K|IFT122_ENST00000504021.1_Missense_Mutation_p.E554K	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	660					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TTTAGATTTTGAAACAGCAAA	0.517000													14	58					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236925843	236925843	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236925843C>T	ENST00000366578.4	+	21	2775	c.2609C>T	c.(2608-2610)tCg>tTg	p.S870L	ACTN2_ENST00000542672.1_Missense_Mutation_p.S870L|ACTN2_ENST00000546208.1_Missense_Mutation_p.S364L	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	870					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CCCGCCTACTCGGGCCCAGGC	0.587000													11	55					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99655367	99655367	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99655367C>T	ENST00000292450.4	+	3	610	c.446C>T	c.(445-447)tCc>tTc	p.S149F	ZSCAN21_ENST00000543588.1_Missense_Mutation_p.S149F|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.S149F|ZSCAN21_ENST00000477297.1_3'UTR	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	149					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GAGAAGATATCCTCCTCAGGA	0.517000													28	61					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124846820	124846820	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124846820G>A	ENST00000356219.3	-	23	3104	c.2949C>T	c.(2947-2949)ccC>ccT	p.P983P	NCOR2_ENST00000404121.2_Silent_p.P537P|NCOR2_ENST00000405201.1_Silent_p.P984P|NCOR2_ENST00000404621.1_Silent_p.P966P|NCOR2_ENST00000429285.2_Silent_p.P966P|NCOR2_ENST00000397355.1_Silent_p.P967P	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	984					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCTCCCGGGGGGGCTCATGGA	0.647000													6	11					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26681985	26681985	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26681985G>A	ENST00000256737.3	+	27	3792	c.2940G>A	c.(2938-2940)tgG>tgA	p.W980*	ANO3_ENST00000537978.1_Nonsense_Mutation_p.W964*|ANO3_ENST00000531568.1_Nonsense_Mutation_p.W834*|ANO3_ENST00000525139.1_Nonsense_Mutation_p.W964*	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	980						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						ACCATGAATGGCCTTAGTTGA	0.418000													26	86					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61533565	61533565	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61533565C>T	ENST00000278836.5	+	3	366	c.270C>T	c.(268-270)ctC>ctT	p.L90L	MYRF_ENST00000265460.5_Silent_p.L81L	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		ATGGTCCCCTCCCACCCCCGG	0.736000													12	26					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699043	52699043	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52699043C>T	ENST00000293525.5	+	5	807	c.755C>T	c.(754-756)tCc>tTc	p.S252F	KRT86_ENST00000544024.1_Missense_Mutation_p.S252F|KRT86_ENST00000423955.2_Missense_Mutation_p.S252F	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	252	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		GTTCTCCAGTCCCACATCTCA	0.552000													21	130					0	0	1	0	0
NUMBL	9253	broad.mit.edu	37	19	41186939	41186939	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41186939G>A	ENST00000252891.4	-	6	590	c.423C>T	c.(421-423)atC>atT	p.I141I	NUMBL_ENST00000540131.1_Silent_p.I100I|NUMBL_ENST00000598779.1_Silent_p.I100I	NM_004756.3	NP_004747.1	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	141	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)	16			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			AGACCTTTTCGATGGTCTGGT	0.537000													60	121					0	0	1	0	0
CEP63	80254	broad.mit.edu	37	3	134256002	134256002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134256002C>T	ENST00000337090.3	+	6	620	c.447C>T	c.(445-447)ttC>ttT	p.F149F	CEP63_ENST00000513612.2_Silent_p.F149F|CEP63_ENST00000606977.1_Silent_p.F149F|CEP63_ENST00000383229.3_Silent_p.F149F|CEP63_ENST00000354446.3_Silent_p.F149F|CEP63_ENST00000332047.5_Silent_p.F149F			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	149					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CTCAGGAATTCCGTCAGAAAT	0.463000													31	68					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42513902	42513902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42513902G>A	ENST00000591680.1	-	4	235	c.205C>T	c.(205-207)Ccc>Tcc	p.P69S	GPATCH8_ENST00000434000.1_5'UTR|GPATCH8_ENST00000586265.1_5'UTR	NM_001002909.2	NP_001002909.1	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	69	G-patch.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ATTGGAATGGGATCTGTTCTC	0.403000													14	31					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10428436	10428436	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10428436G>A	ENST00000293677.6	-	12	2135	c.2054C>T	c.(2053-2055)tCc>tTc	p.S685F	CTD-2369P2.12_ENST00000586529.1_Missense_Mutation_p.S86F	NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	512						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CCCCAGCGGGGAAGAGCCGAT	0.697000													4	14					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144886117	144886117	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:144886117G>A	ENST00000369359.4	-	26	3566	c.3528C>T	c.(3526-3528)ttC>ttT	p.F1176F	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369356.4_Silent_p.F1039F|PDE4DIP_ENST00000369354.3_Silent_p.F1039F|PDE4DIP_ENST00000313382.9_Silent_p.F1105F|PDE4DIP_ENST00000530740.1_Silent_p.F1176F			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1039					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ACACTGAGGAGAATCCTGCTT	0.547000			T	PDGFRB	MPD								23	109					0	0	1	0	0
KRT18	3875	broad.mit.edu	37	12	53343040	53343040	+	Missense_Mutation	SNP	C	C	T	rs74379840		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53343040C>T	ENST00000550600.1	+	2	137	c.83C>T	c.(82-84)cCg>cTg	p.P28L	KRT18_ENST00000388835.3_Missense_Mutation_p.P28L|KRT8_ENST00000546897.1_Intron|KRT18_ENST00000388837.2_Missense_Mutation_p.P28L|KRT8_ENST00000552551.1_Intron|KRT8_ENST00000549198.1_Intron			P05783	K1C18_HUMAN	keratin 18	28	Head.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						GGCGCCCGGCCGGTCAGCAGC	0.697000													46	94					0	0	1	0	0
NR2E3	10002	broad.mit.edu	37	15	72105971	72105971	+	RNA	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72105971A>G	ENST00000398840.2	+	0	1179							Q9Y5X4	NR2E3_HUMAN	nuclear receptor subfamily 2, group E, member 3						phototransduction|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|endometrium(1)|lung(1)	3						GTCCTCTTCAAGCCAGGTAAC	0.567000													11	67					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73834126	73834126	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73834126G>A	ENST00000334126.7	-	8	1498	c.1272C>T	c.(1270-1272)tcC>tcT	p.S424S	C2CD3_ENST00000313663.7_Silent_p.S424S			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	424						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					CAGGAGATGGGGAATCTGGAG	0.428000													18	53					0	0	1	0	0
MFSD7	84179	broad.mit.edu	37	4	680390	680390	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:680390G>A	ENST00000322224.4	-	2	538	c.225C>T	c.(223-225)taC>taT	p.Y75Y	MFSD7_ENST00000404286.2_Silent_p.Y75Y|MFSD7_ENST00000503156.1_Silent_p.Y11Y|MFSD7_ENST00000515118.1_Silent_p.Y75Y|MFSD7_ENST00000347950.5_Silent_p.Y53Y|MFSD7_ENST00000513740.1_5'UTR			Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing 7	75					transmembrane transport	integral to membrane				cervix(1)|kidney(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	11						ATACCACGAGGTAGACCAGTG	0.627000													24	79					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21715852	21715852	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21715852C>T	ENST00000261195.2	-	7	1316	c.1062_splice	c.e7+1	p.R354_splice		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	354					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GCTTTCTTACCCTCAGCAGGA	0.383000													24	156					0	0	1	0	0
THRAP3	9967	broad.mit.edu	37	1	36755299	36755299	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36755299C>T	ENST00000354618.5	+	5	1903	c.1679C>T	c.(1678-1680)tCc>tTc	p.S560F	THRAP3_ENST00000469141.2_Missense_Mutation_p.S560F	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	560					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGAAAGTCTTCCTTTTCCATT	0.502000			T	USP6	aneurysmal bone cysts								28	100					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57187685	57187685	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57187685G>A	ENST00000331162.4	-	5	1707	c.1437C>T	c.(1435-1437)acC>acT	p.T479T		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GTTGCATAAGGGTTGAGGAGC	0.403000													11	101					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36779912	36779912	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36779912G>A	ENST00000416516.2	-	2	729	c.239C>T	c.(238-240)cCc>cTc	p.P80L		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	80						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						AAGCTCCTCGGGGATCTTCCC	0.612000													74	171					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77662426	77662426	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77662426G>A	ENST00000296043.6	+	5	4053	c.3100G>A	c.(3100-3102)Gag>Aag	p.E1034K		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1034					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GATCGTGGAGGAGGCCGAACC	0.692000													7	36					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228481217	228481217	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228481217C>T	ENST00000570156.2	+	46	12392	c.12318C>T	c.(12316-12318)gcC>gcT	p.A4106A	OBSCN_ENST00000366707.4_Silent_p.A796A|OBSCN_ENST00000422127.1_Silent_p.A3677A|OBSCN_ENST00000359599.6_Silent_p.A2524A|OBSCN_ENST00000284548.11_Silent_p.A3677A|OBSCN_ENST00000366709.4_Silent_p.A796A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3148	Ig-like 42.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGACGGGGCCAGGTGTGAGC	0.647000													35	56					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45399639	45399639	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45399639C>T	ENST00000389039.6	-	14	1982	c.1597G>A	c.(1597-1599)Gaa>Aaa	p.E533K	DUOX2_ENST00000603300.1_Missense_Mutation_p.E533K			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	533	Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CGGATGTCTTCAATCTCCTTC	0.552000													42	102					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32474867	32474867	+	Missense_Mutation	SNP	C	C	T	rs150636128		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:32474867C>T	ENST00000404025.2	-	5	2554	c.2066G>A	c.(2065-2067)aGc>aAc	p.S689N	NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Missense_Mutation_p.S689N|NLRC4_ENST00000360906.5_Missense_Mutation_p.S689N			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	689					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAGCCTGAGGCTTGTGGCAGA	0.468000													34	92					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204953175	204953175	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204953175G>A	ENST00000367172.4	+	22	2819	c.2491G>A	c.(2491-2493)Gaa>Aaa	p.E831K	NFASC_ENST00000404076.1_Missense_Mutation_p.E810K|NFASC_ENST00000513543.1_Missense_Mutation_p.E827K|NFASC_ENST00000367171.4_Missense_Mutation_p.E816K|NFASC_ENST00000339876.6_Intron|NFASC_ENST00000539706.1_Missense_Mutation_p.E827K|NFASC_ENST00000404907.1_Missense_Mutation_p.E827K|NFASC_ENST00000360049.4_Missense_Mutation_p.E827K|NFASC_ENST00000367170.4_Missense_Mutation_p.E831K|NFASC_ENST00000401399.1_Intron|NFASC_ENST00000367169.4_Intron|NFASC_ENST00000338586.6_Missense_Mutation_p.E831K|NFASC_ENST00000338515.6_Missense_Mutation_p.E831K			O94856	NFASC_HUMAN	neurofascin	831	Fibronectin type-III 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGCGCCCACTGAAGTTAAAGT	0.557000													7	46					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142626553	142626553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142626553G>A	ENST00000265310.1	-	4	805	c.457C>T	c.(457-459)Cgc>Tgc	p.R153C	TRPV5_ENST00000442623.1_Missense_Mutation_p.R153C	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	153					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GGACTACGGCGGAAGGCAGTG	0.617000													32	74					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4923295	4923295	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4923295G>A	ENST00000320785.5	+	19	2028	c.1671G>A	c.(1669-1671)gtG>gtA	p.V557V	KIF1C_ENST00000573815.1_3'UTR|AC109333.10_ENST00000438266.1_RNA	NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	557	FHA.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						ATTCAGTGGTGGTCACTCTGG	0.527000													8	5					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96447569	96447569	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96447569C>T	ENST00000285979.6	+	2	410	c.211C>T	c.(211-213)Ctg>Ttg	p.L71L	CYP2C18_ENST00000339022.5_Silent_p.L71L	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GTATTTTGGCCTGAAGCCCAT	0.418000													29	249					0	0	1	0	0
PPAP2A	8611	broad.mit.edu	37	5	54771130	54771130	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:54771130G>A	ENST00000307259.8	-	2	627	c.207C>T	c.(205-207)atC>atT	p.I69I	PPAP2A_ENST00000264775.5_Intron|PPAP2A_ENST00000515132.1_Intron	NM_003711.2	NP_003702.2	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A	69					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	9		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				AACTTACAACGATAATACTGA	0.338000													10	17					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36017667	36017667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36017667C>T	ENST00000452271.2	-	1	1545	c.1517G>A	c.(1516-1518)gGa>gAa	p.G506E	SBSN_ENST00000518157.1_Missense_Mutation_p.G163E	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	163						extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CACTTCCTTTCCAGCCTGGTC	0.592000													10	89					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30307468	30307468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:30307468G>A	ENST00000361371.4	-	27	4988	c.4838C>T	c.(4837-4839)tCt>tTt	p.S1613F	LTN1_ENST00000389194.2_Missense_Mutation_p.S1659F	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	1613							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						TGTTTGTACAGAAGATATTTC	0.343000													26	62					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49395053	49395053	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49395053G>A	ENST00000419783.1	-	2	701	c.380C>T	c.(379-381)gCc>gTc	p.A127V	GPX1_ENST00000419349.1_3'UTR|GPX1_ENST00000496791.1_5'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	127					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	CCGCAGGAAGGCGAAGAGAGG	0.632000													27	51					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38655202	38655202	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38655202C>T	ENST00000222345.6	+	15	4373	c.3864C>T	c.(3862-3864)ttC>ttT	p.F1288F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1288					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACCGCTGGTTCGACCCCCTGG	0.607000													9	93					0	0	1	0	0
OR51A2	401667	broad.mit.edu	37	11	4976080	4976080	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4976080C>T	ENST00000380371.1	-	1	863	c.864G>A	c.(862-864)atG>atA	p.M288I	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004748.1	NP_001004748.1	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A, member 2	288			M -> T (in dbSNP:rs2442426).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAATTGGTTTCATCAGCGGAG	0.418000													38	64					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152831474	152831474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152831474G>A	ENST00000367255.5	-	8	1036	c.435C>T	c.(433-435)ctC>ctT	p.L145L	SYNE1_ENST00000466159.2_Silent_p.L145L|SYNE1_ENST00000341594.5_Silent_p.L145L|SYNE1_ENST00000367248.3_Silent_p.L152L|SYNE1_ENST00000423061.1_Silent_p.L152L|SYNE1_ENST00000448038.1_Silent_p.L152L|SYNE1_ENST00000265368.4_Silent_p.L145L|SYNE1_ENST00000413186.2_Silent_p.L145L|SYNE1_ENST00000367253.4_Silent_p.L145L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	145	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACAAAGACTGGAGCTGGGGCA	0.458000										HNSCC(10;0.0054)			22	22					0	0	1	0	0
NPS	594857	broad.mit.edu	37	10	129350866	129350866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129350866G>A	ENST00000398023.1	+	3	253	c.233G>A	c.(232-234)gGg>gAg	p.G78E		NM_001030013.1	NP_001025184.1	P0C0P6	NPS_HUMAN	neuropeptide S	78					neuropeptide signaling pathway	extracellular region				haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						GTTGGCACAGGGATGAAAAAA	0.413000													55	148					0	0	1	0	0
RAX	30062	broad.mit.edu	37	18	56939653	56939653	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56939653C>T	ENST00000334889.3	-	2	669	c.483G>A	c.(481-483)ccG>ccA	p.P161P	RAX_ENST00000256852.7_Intron	NM_013435.2	NP_038463.2	Q9Y2V3	RX_HUMAN	retina and anterior neural fold homeobox	161					visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	6		Lung NSC(161;0.0804)|Colorectal(73;0.0946)		STAD - Stomach adenocarcinoma(84;0.18)		TGTACACGTCCGGGTAGTGGG	0.622000													34	51					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42225911	42225911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:42225911G>A	ENST00000541110.1	-	10	2926	c.2358C>T	c.(2356-2358)gtC>gtT	p.V786V	TRERF1_ENST00000354325.2_Silent_p.V683V|TRERF1_ENST00000340840.2_Silent_p.V683V|TRERF1_ENST00000372917.4_Silent_p.V683V|TRERF1_ENST00000372922.4_Silent_p.V766V			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	766	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCCCTGGGGTGACCGTCACGT	0.433000													15	35					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21239752	21239752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:21239752C>T	ENST00000261560.5	+	5	819	c.638C>T	c.(637-639)tCg>tTg	p.S213L		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						TGTGACAAATCGTTTTGCATG	0.284000													9	27					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95606832	95606832	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:95606832G>A	ENST00000324972.6	+	7	743	c.550G>A	c.(550-552)Gaa>Aaa	p.E184K	DYNC1I1_ENST00000447467.2_Missense_Mutation_p.E167K|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.E164K|DYNC1I1_ENST00000359388.4_Missense_Mutation_p.E147K|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.E147K|DYNC1I1_ENST00000457059.1_Missense_Mutation_p.E167K	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	184					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			AGAGGATGAGGAAGATGAGGA	0.368000													19	25					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32090200	32090200	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:32090200C>G	ENST00000438447.1	+	20	7034	c.6646C>G	c.(6646-6648)Cca>Gca	p.P2216A	PDZD2_ENST00000282493.3_Missense_Mutation_p.P2216A			O15018	PDZD2_HUMAN	PDZ domain containing 2	2216					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CTACTTCACCCCAAGGCCAGC	0.617000													62	336					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941685	144941685	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144941685G>A	ENST00000525985.1	-	2	5808	c.5737C>T	c.(5737-5739)Ctc>Ttc	p.L1913F				P58107	EPIPL_HUMAN	epiplakin 1	1913						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCTCATGGAGGCTCATGACC	0.662000													9	37					0	0	1	0	0
C3orf36	80111	broad.mit.edu	37	3	133647250	133647250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133647250G>A	ENST00000408895.2	-	1	1406	c.398C>T	c.(397-399)tCt>tTt	p.S133F		NM_025041.2	NP_079317.2	Q3SXR2	CC036_HUMAN	chromosome 3 open reading frame 36	133	Poly-Ser.									breast(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)	6						GAAGGTGGAAGAGGAAGAGAG	0.592000													14	45					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186671899	186671899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:186671899G>A	ENST00000343098.5	+	17	18133	c.18133G>A	c.(18133-18135)Gaa>Aaa	p.E6045K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E5956K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AGTGATAAATGAAATTTTCCA	0.318000													46	123					0	0	1	0	0
PROP1	5626	broad.mit.edu	37	5	177421114	177421114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:177421114C>T	ENST00000308304.2	-	2	643	c.335G>A	c.(334-336)cGa>cAa	p.R112Q		NM_006261.4	NP_006252.3	O75360	PROP1_HUMAN	PROP paired-like homeobox 1	112					central nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(9)|stomach(1)	13	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACCTGGATTCGGGCCTCACT	0.527000													37	102					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899198	233899198	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233899198C>T	ENST00000233840.3	+	2	574	c.574C>T	c.(574-576)Ccc>Tcc	p.P192S		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	192							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		AAGGCCGATCCCCTCTGCCTT	0.657000													38	70					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72680646	72680646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72680646C>T	ENST00000261180.4	+	2	1061	c.965C>T	c.(964-966)tCa>tTa	p.S322L		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	322					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GATCACTTTTCACAGACCCCT	0.403000													41	117					0	0	1	0	0
CYTL1	54360	broad.mit.edu	37	4	5021056	5021056	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:5021056G>A	ENST00000307746.4	-	1	143	c.117C>T	c.(115-117)acC>acT	p.T39T		NM_018659.2	NP_061129.1	Q9NRR1	CYTL1_HUMAN	cytokine-like 1	39					signal transduction	extracellular space|soluble fraction	receptor binding			breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		TGAAGTCGCGGGTGATCTCCT	0.692000													6	14					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361191	107361191	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107361191G>A	ENST00000374779.2	-	1	597	c.504C>T	c.(502-504)ttC>ttT	p.F168F		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						TATTCCTGCAGAAAGGCAATT	0.448000													20	194					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43912144	43912144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:43912144G>A	ENST00000339069.5	+	13	1454	c.823G>A	c.(823-825)Gga>Aga	p.G275R	CRHR1_ENST00000398285.3_3'UTR|CRHR1_ENST00000314537.5_3'UTR			P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	0					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		GGCAGGTCATGGAGCAGCCCC	0.642000													12	22					0	0	1	0	0
OPALIN	93377	broad.mit.edu	37	10	98108055	98108055	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98108055C>T	ENST00000419479.1	-	6	717	c.210G>A	c.(208-210)aaG>aaA	p.K70K	OPALIN_ENST00000393870.2_Silent_p.K69K|OPALIN_ENST00000393871.1_Silent_p.K57K|OPALIN_ENST00000371172.3_Silent_p.K80K|OPALIN_ENST00000536387.1_Silent_p.K70K	NM_001040103.1	NP_001035192.1	Q96PE5	OPALI_HUMAN	oligodendrocytic myelin paranodal and inner loop protein	80						Golgi apparatus|integral to membrane|plasma membrane				breast(1)|large_intestine(1)|lung(5)|prostate(2)	9						CCTCAGATATCTTGGGATTGT	0.333000													17	62					0	0	1	0	0
DIXDC1	85458	broad.mit.edu	37	11	111889718	111889718	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111889718G>A	ENST00000440460.2	+	21	2304	c.2007G>A	c.(2005-2007)ggG>ggA	p.G669G	DIXDC1_ENST00000315253.5_Silent_p.G458G|DIXDC1_ENST00000389821.4_3'UTR	NM_001037954.2	NP_001033043.1	Q155Q3	DIXC1_HUMAN	DIX domain containing 1	670	DIX.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	17		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		GATGGGAAGGGAAAATTGTAG	0.428000													28	74					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72509681	72509681	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72509681G>A	ENST00000373208.1	+	16	2376	c.2376G>A	c.(2374-2376)gtG>gtA	p.V792V	ADAMTS14_ENST00000373207.1_Silent_p.V789V	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	789	Spacer.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						AGGATGCGGTGGAGGATGCCA	0.642000													12	57					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350414	51350414	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51350414C>T	ENST00000327536.5	-	3	642	c.543G>A	c.(541-543)cgG>cgA	p.R181R	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	181										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		ACTGGTTGTTCCGGTAGAGGA	0.468000													46	105					0	0	1	0	0
ZNF823	55552	broad.mit.edu	37	19	11833307	11833307	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11833307G>A	ENST00000341191.6	-	4	1195	c.1042C>T	c.(1042-1044)Cga>Tga	p.R348*	ZNF823_ENST00000545749.1_Nonsense_Mutation_p.R166*	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	348					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R348*(2)		breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						TCATGATTTCGAACTGAACTA	0.418000										HNSCC(68;0.2)			20	155					0	0	1	0	0
IGHV3-23	28442	broad.mit.edu	37	14	106725366	106725366	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106725366C>T	ENST00000390609.2	-	0	264																											ACTCCAGCCCCTTCCCTGGAG	0.577000													51	490					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41621803	41621803	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41621803C>T	ENST00000216237.5	+	12	1520	c.1362C>T	c.(1360-1362)ctC>ctT	p.L454L		NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	454					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCCAGGTTCTCCTGGATGGAT	0.597000													17	44					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47162320	47162320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47162320G>A	ENST00000409792.3	-	3	3848	c.3806C>T	c.(3805-3807)aCc>aTc	p.T1269I		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1269				T -> A (in Ref. 4; CAC28349, 6; AAT77612 and 7; AAT77613).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTGATACGTGGTAGAAGGCTT	0.463000			"""N, F, S, Mis"""		clear cell renal carcinoma								37	87					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30702494	30702494	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30702494C>T	ENST00000256246.2	-	1	4114	c.4040G>A	c.(4039-4041)gGa>gAa	p.G1347E		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1347										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGAAGATTCTCCCTCACTATC	0.408000													15	129					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348928	89348928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89348928G>A	ENST00000301030.4	-	9	4482	c.4022C>T	c.(4021-4023)cCt>cTt	p.P1341L	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1341L	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1341	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CAGCTTCTCAGGGAGGCAGGC	0.592000													24	52					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17791332	17791332	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:17791332G>A	ENST00000380607.4	+	7	848	c.728_splice	c.e7+1	p.R243_splice	SH3GL2_ENST00000537391.1_Splice_Site_p.R196_splice	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	243	BAR.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		CTGGAAGAAAGGTATTCTACA	0.428000													5	71					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	78005818	78005818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:78005818C>T	ENST00000302536.2	+	8	1302	c.1149C>T	c.(1147-1149)acC>acT	p.T383T		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	383							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						TAGAAAAGACCCCAACTCCAC	0.532000											OREG0023950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	222					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79385646	79385646	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79385646C>T	ENST00000264895.6	+	49	7378	c.6938C>T	c.(6937-6939)cCc>cTc	p.P2313L		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2312					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GATTCGCTGCCCGTCGTACAG	0.532000													12	79					0	0	1	0	0
NDUFC2	4718	broad.mit.edu	37	11	77784157	77784157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:77784157G>A	ENST00000281031.4	-	2	671	c.197C>T	c.(196-198)gCc>gTc	p.A66V	NDUFC2_ENST00000534029.1_Intron|NDUFC2-KCTD14_ENST00000530054.1_Missense_Mutation_p.A66V|NDUFC2-KCTD14_ENST00000528251.1_Intron|NDUFC2_ENST00000528164.1_Missense_Mutation_p.A66V|NDUFC2_ENST00000527806.1_Missense_Mutation_p.A66V|NDUFC2_ENST00000525085.1_Intron	NM_001204055.1|NM_004549.5	NP_001190984.1|NP_004540.1			NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa											large_intestine(1)|lung(2)|prostate(1)	4	all_cancers(14;2.23e-19)|all_epithelial(13;7.49e-22)|Breast(9;6.38e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;2.15e-25)			AAAAAAAAAGGCCGTAATATA	0.353000													31	101					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29998372	29998372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29998372C>T	ENST00000308893.4	+	16	3822	c.2779C>T	c.(2779-2781)Cct>Tct	p.P927S	TAOK2_ENST00000543033.1_Missense_Mutation_p.P814S|TAOK2_ENST00000416441.2_Missense_Mutation_p.P754S|TAOK2_ENST00000279394.3_Intron	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	927					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CCCCGACATCCCTCCTGAACC	0.647000													51	218					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49218978	49218978	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49218978G>A	ENST00000327979.2	-	13	1689	c.1278C>T	c.(1276-1278)ggC>ggT	p.G426G	FAM65C_ENST00000045083.2_Silent_p.G426G|FAM65C_ENST00000535356.1_Silent_p.G430G			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	426										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGGGCAGGAAGCCCACATCTG	0.637000													25	66					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40357749	40357749	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40357749G>A	ENST00000221347.6	-	34	15571	c.15564C>T	c.(15562-15564)tcC>tcT	p.S5188S		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5188	Cys-rich.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGGTCAGCAGGGAGGAGTTTA	0.572000													16	28					0	0	1	0	0
FOXI2	399823	broad.mit.edu	37	10	129536850	129536850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129536850G>A	ENST00000388920.4	+	2	617	c.578G>A	c.(577-579)aGg>aAg	p.R193K		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	193					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				AACTTCCGAAGGAAGAGGAAG	0.622000													8	20					0	0	1	0	0
PRR16	51334	broad.mit.edu	37	5	120022371	120022371	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:120022371G>A	ENST00000379551.2	+	3	1170	c.813G>A	c.(811-813)acG>acA	p.T271T	PRR16_ENST00000446965.1_Silent_p.T224T|PRR16_ENST00000505123.1_Silent_p.T224T|PRR16_ENST00000407149.2_Silent_p.T294T	NM_016644.1	NP_057728.1	Q569H4	PRR16_HUMAN	proline rich 16	294	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CACAGAAGACGATCTTGAGGA	0.398000													19	40					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14355033	14355033	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:14355033T>C	ENST00000571589.1	+	17	3204	c.3032T>C	c.(3031-3033)cTg>cCg	p.L1011P	MKL2_ENST00000574045.1_Missense_Mutation_p.L961P|MKL2_ENST00000341243.5_Missense_Mutation_p.L1000P|MKL2_ENST00000318282.5_Missense_Mutation_p.L961P	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	1000					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCCTTCTCTCTGATCGAGGAC	0.488000													7	62					0	0	1	0	0
DTX1	1840	broad.mit.edu	37	12	113532957	113532957	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113532957C>T	ENST00000257600.3	+	7	2000	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	DTX1_ENST00000547974.1_3'UTR	NM_004416.2	NP_004407.2	Q86Y01	DTX1_HUMAN	deltex homolog 1 (Drosophila)	499					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	32						TGCCCGGCTTCCCTGATACCC	0.652000													21	82					0	0	1	0	0
NR2E1	7101	broad.mit.edu	37	6	108499402	108499402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:108499402C>T	ENST00000368986.4	+	5	1307	c.599C>T	c.(598-600)gCt>gTt	p.A200V	NR2E1_ENST00000368983.3_Missense_Mutation_p.A237V	NM_003269.3	NP_003260.1	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	200	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		ATCAAGTGGGCTAAGAGTGTG	0.527000													21	32					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43872643	43872643	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:43872643G>A	ENST00000261488.6	-	12	1862	c.1285C>T	c.(1285-1287)Ctg>Ttg	p.L429L	ENOX1_ENST00000412891.1_Silent_p.L429L	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	429					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TCCTCTTTCAGAGCGTAGGCC	0.527000													32	75					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19760619	19760619	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19760619G>A	ENST00000357324.6	-	18	2492	c.2466C>T	c.(2464-2466)acC>acT	p.T822T	ATP13A1_ENST00000291503.5_Silent_p.T704T	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	822					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GCTGGGGGTCGGTGGCCTGCA	0.687000													7	36					0	0	1	0	0
BSPRY	54836	broad.mit.edu	37	9	116132182	116132182	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116132182C>T	ENST00000374183.4	+	6	1008	c.969C>T	c.(967-969)ttC>ttT	p.F323F	BSPRY_ENST00000462085.1_3'UTR	NM_017688.2	NP_060158.2	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	323	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						ACAATGCCTTCTCCTGGGTCT	0.607000													22	44					0	0	1	0	0
C7orf10	79783	broad.mit.edu	37	7	40277264	40277264	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:40277264G>A	ENST00000309930.5	+	7	560	c.536G>A	c.(535-537)cGa>cAa	p.R179Q	C7orf10_ENST00000335693.4_Missense_Mutation_p.R179Q|C7orf10_ENST00000401647.2_Missense_Mutation_p.R179Q	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	179							transferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						ATTTCTCAGCGAGCTGGTTAT	0.433000													26	55					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71095058	71095058	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71095058C>T	ENST00000283228.2	-	7	1505	c.1053G>A	c.(1051-1053)ggG>ggA	p.G351G	PTPRR_ENST00000549308.1_Silent_p.G106G|PTPRR_ENST00000378778.1_Silent_p.G145G|PTPRR_ENST00000440835.2_Silent_p.G106G|PTPRR_ENST00000342084.4_Silent_p.G239G	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	351					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		GTTCAATGTTCCCCAAGCTAC	0.438000													20	80					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183104955	183104955	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:183104955G>T	ENST00000435564.1	-	3	480	c.280C>A	c.(280-282)Cgg>Agg	p.R94R	PDE1A_ENST00000346717.4_Silent_p.R60R|PDE1A_ENST00000358139.2_Silent_p.R94R|PDE1A_ENST00000331935.6_Silent_p.R94R|PDE1A_ENST00000456212.1_Silent_p.R94R|PDE1A_ENST00000536095.1_5'UTR|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000410103.1_Silent_p.R94R|PDE1A_ENST00000409365.1_Silent_p.R78R|PDE1A_ENST00000351439.5_Silent_p.R78R	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	94					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.R94W(4)		endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			AACCAGTCCCGGACTTCAGAT	0.393000													30	68					8.88839e-20	8.943e-20	1	1	0
MCUR1	63933	broad.mit.edu	37	6	13807255	13807255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13807255G>A	ENST00000379170.4	-	2	575	c.437C>T	c.(436-438)tCc>tTc	p.S146F	MCUR1_ENST00000359495.2_Missense_Mutation_p.S146F	NM_001031713.3	NP_001026883.1			mitochondrial calcium uniporter regulator 1																		CAGCTGCAGGGATCCAGCAGA	0.473000													40	65					0	0	1	0	0
STAC	6769	broad.mit.edu	37	3	36524562	36524562	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36524562C>T	ENST00000273183.3	+	3	767	c.467C>T	c.(466-468)cCc>cTc	p.P156L	STAC_ENST00000457375.2_Intron|STAC_ENST00000476388.1_3'UTR	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	156					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						GGCCTGGCACCCCAGCGGTGC	0.572000													9	57					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23250889	23250889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:23250889C>T	ENST00000298032.5	+	7	698	c.614C>T	c.(613-615)cCa>cTa	p.P205L	ARMC3_ENST00000409049.3_Missense_Mutation_p.P205L|ARMC3_ENST00000376528.4_Intron|ARMC3_ENST00000409983.3_Missense_Mutation_p.P205L	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	205							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TCAGAATATCCAGTGATTCAG	0.373000													15	38					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20893163	20893163	+	Missense_Mutation	SNP	G	G	A	rs149798560		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:20893163G>A	ENST00000381552.1	+	12	1962	c.1594G>A	c.(1594-1596)Gga>Aga	p.G532R	SLCO1C1_ENST00000545102.1_Missense_Mutation_p.G414R|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.G483R|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.G532R|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.G532R			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	532					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TTCTAAATCCGGAAATTCCTC	0.353000													27	98					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33154504	33154504	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33154504C>T	ENST00000341947.2	-	5	925	c.698G>A	c.(697-699)aGg>aAg	p.R233K	COL11A2_ENST00000357486.1_Missense_Mutation_p.R233K|COL11A2_ENST00000361917.1_Missense_Mutation_p.R233K|COL11A2_ENST00000374708.4_Missense_Mutation_p.R233K|COL11A2_ENST00000395197.1_Missense_Mutation_p.R233K|COL11A2_ENST00000374712.1_Missense_Mutation_p.R233K|COL11A2_ENST00000374713.1_Missense_Mutation_p.R233K|COL11A2_ENST00000395194.1_Missense_Mutation_p.R233K|COL11A2_ENST00000374714.1_Missense_Mutation_p.R233K	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	233	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GGGTCTTTCCCTCTGGCCCCC	0.562000													48	102					0	0	1	0	0
PHF7	51533	broad.mit.edu	37	3	52457136	52457136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52457136C>T	ENST00000327906.3	+	11	1609	c.949C>T	c.(949-951)Cct>Tct	p.P317S	PHF7_ENST00000478707.1_Missense_Mutation_p.P317S|PHF7_ENST00000347025.2_Missense_Mutation_p.P278S	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	317						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		AGGGGACATCCCTTGCTGCAG	0.527000													38	87					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21747441	21747441	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21747441G>A	ENST00000328843.6	+	41	6723	c.6692G>A	c.(6691-6693)tGg>tAg	p.W2231*	DNAH11_ENST00000409508.3_Nonsense_Mutation_p.W2224*			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2231	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ACCCGAGAATGGAAAGATGGC	0.378000									Kartagener syndrome				4	44					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90904247	90904247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90904247G>A	ENST00000354377.3	+	4	1370	c.1184G>A	c.(1183-1185)cGa>cAa	p.R395Q	ZNF774_ENST00000379090.5_Intron	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AAGCACCAACGAATCCACACC	0.498000													16	68					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66426077	66426077	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66426077C>T	ENST00000341529.3	+	7	1156	c.1008C>T	c.(1006-1008)atC>atT	p.I336I	CDH5_ENST00000563425.2_Silent_p.I336I	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	336	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		ACAGCTTCATCGTCGAGGCCA	0.542000													52	186					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20491956	20491956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20491956G>A	ENST00000573854.1	+	11	1457	c.1343G>A	c.(1342-1344)gGa>gAa	p.G448E	ACSM2A_ENST00000575690.1_Missense_Mutation_p.G448E|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.G448E|ACSM2A_ENST00000536134.1_Missense_Mutation_p.G220E|ACSM2A_ENST00000417235.2_Missense_Mutation_p.G369E|ACSM2A_ENST00000396104.2_Missense_Mutation_p.G448E	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	448					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GGAGACCGGGGAATCAAAGAT	0.488000													10	88					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26676280	26676280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26676280G>A	ENST00000288710.2	+	14	1856	c.1782G>A	c.(1780-1782)atG>atA	p.M594I		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		agacggagatggagggagaaa	0.572000													28	69					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73513451	73513451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:73513451C>T	ENST00000418310.1	+	5	683	c.581C>T	c.(580-582)aCc>aTc	p.T194I	LIMK1_ENST00000336180.2_Missense_Mutation_p.T164I|LIMK1_ENST00000538333.3_Missense_Mutation_p.T130I|LIMK1_ENST00000491052.1_3'UTR			P53667	LIMK1_HUMAN	LIM domain kinase 1	164	PDZ.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				CACACCGTCACCCTGGTGTCC	0.647000													53	124					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179643770	179643770	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179643770C>T	ENST00000589042.1	-	24	4263	c.4039G>A	c.(4039-4041)Gct>Act	p.A1347T	TTN_ENST00000342992.6_Missense_Mutation_p.A1347T|TTN_ENST00000360870.5_Missense_Mutation_p.A1347T|TTN_ENST00000460472.2_Missense_Mutation_p.A1301T|TTN_ENST00000342175.6_Missense_Mutation_p.A1301T|TTN_ENST00000359218.5_Missense_Mutation_p.A1301T|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.A1347T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1347	Ig-like 5.		A -> T (in a metastatic melanoma sample; somatic mutation).				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.A1301T(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCAGACTAGCTCTGCCATCT	0.403000													14	57					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170805228	170805228	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170805228G>A	ENST00000436636.2	-	24	3133	c.2789C>T	c.(2788-2790)cCt>cTt	p.P930L	TNIK_ENST00000460047.1_Missense_Mutation_p.P867L|TNIK_ENST00000538048.1_Missense_Mutation_p.P882L|TNIK_ENST00000369326.5_Missense_Mutation_p.P908L|TNIK_ENST00000284483.8_Missense_Mutation_p.P922L|TNIK_ENST00000470834.1_Missense_Mutation_p.P893L|TNIK_ENST00000357327.5_Missense_Mutation_p.P901L|TNIK_ENST00000488470.1_Missense_Mutation_p.P875L|TNIK_ENST00000475336.1_Missense_Mutation_p.P838L|TNIK_ENST00000341852.6_Missense_Mutation_p.P846L	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	930	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CACCAGGTCAGGGAGGTTGAT	0.587000													28	82					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962660	41962660	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:41962660C>T	ENST00000454645.1	-	0	844					NR_003670.1																						ATTTCCCCTCCGTTGTTTGTC	0.363000													5	47					0	0	1	0	0
CNTFR	1271	broad.mit.edu	37	9	34564810	34564810	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34564810C>T	ENST00000378980.3	-	4	399	c.106G>A	c.(106-108)Gag>Aag	p.E36K	CNTFR_ENST00000351266.4_Missense_Mutation_p.E36K	NM_001207011.1|NM_147164.2	NP_001193940.1|NP_671693.1	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	36	Ig-like C2-type.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(4)|skin(1)	15	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		CCCAGGCGCTCGTACTGCACA	0.652000													15	37					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75444658	75444658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:75444658C>T	ENST00000549446.1	-	3	1807	c.1127G>A	c.(1126-1128)cGa>cAa	p.R376Q	KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000298972.1_Missense_Mutation_p.R376Q|KCNC2_ENST00000341669.3_Missense_Mutation_p.R376Q|KCNC2_ENST00000548513.1_Missense_Mutation_p.R376Q|KCNC2_ENST00000393288.2_Missense_Mutation_p.R376Q|KCNC2_ENST00000540018.1_Missense_Mutation_p.R376Q|KCNC2_ENST00000550433.1_Missense_Mutation_p.R376Q|KCNC2_ENST00000350228.2_Missense_Mutation_p.R376Q	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	376					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						AGTACTAGCTCGAAGAGTATG	0.453000													6	48					0	0	1	0	0
SVOPL	136306	broad.mit.edu	37	7	138314867	138314867	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138314867C>T	ENST00000421622.1	-	6	638	c.429_splice	c.e6-1	p.E144_splice	SVOPL_ENST00000436657.1_Splice_Site_p.E112_splice|SVOPL_ENST00000419765.3_Splice_Site_p.E264_splice|SVOPL_ENST00000288513.5_Splice_Site_p.E112_splice			Q8N434	SVOPL_HUMAN	SVOP-like	264						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						CCTCTTTTTTCCTGGGGTAAT	0.388000													11	55					0	0	1	0	0
BCL6B	255877	broad.mit.edu	37	17	6930397	6930397	+	Silent	SNP	G	G	A	rs117980493	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6930397G>A	ENST00000293805.5	+	8	1406	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K		NM_181844.3	NP_862827.1	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B	438						nucleus	zinc ion binding			skin(1)	1						CCGGAGAGAAGCCTTACCACG	0.632000													15	43					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25266961	25266961	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:25266961C>T	ENST00000218548.6	+	10	1655	c.1322C>T	c.(1321-1323)tCc>tTc	p.S441F	ATP12A_ENST00000381946.3_Missense_Mutation_p.S435F	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	435					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ACTTGGGCCTCCTTATCCAAG	0.493000													63	267					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7629892	7629892	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:7629892C>T	ENST00000340209.4	+	3	696	c.399C>T	c.(397-399)ttC>ttT	p.F133F	RBFOX1_ENST00000552089.1_Silent_p.F163F|RBFOX1_ENST00000550418.1_Silent_p.F128F|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000436368.2_Silent_p.F148F|RBFOX1_ENST00000547338.1_Silent_p.F128F|RBFOX1_ENST00000553186.1_Silent_p.F128F|RBFOX1_ENST00000311745.5_Silent_p.F148F|RBFOX1_ENST00000355637.4_Silent_p.F148F|RBFOX1_ENST00000422070.4_Silent_p.F171F|RBFOX1_ENST00000547372.1_Silent_p.F171F			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	128	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						CCTTCAGGTTCCGGGATCCGG	0.547000													22	51					0	0	1	0	0
ZNF445	353274	broad.mit.edu	37	3	44489665	44489665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:44489665G>A	ENST00000425708.2	-	7	1839	c.1498C>T	c.(1498-1500)Ctt>Ttt	p.L500F	ZNF445_ENST00000396077.2_Missense_Mutation_p.L500F			P59923	ZN445_HUMAN	zinc finger protein 445	500					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		TGATACGCAAGATGGGAGCTA	0.493000													42	72					0	0	1	0	0
ARHGAP10	79658	broad.mit.edu	37	4	148968136	148968136	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:148968136C>T	ENST00000336498.3	+	20	2200	c.1961C>T	c.(1960-1962)cCt>cTt	p.P654L	ARHGAP10_ENST00000414545.2_Missense_Mutation_p.P303L	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	654					apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		GTCCCTGGGCCTCCTGGACCA	0.562000													25	61					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131864564	131864564	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131864564G>A	ENST00000359827.3	-	20	4718	c.3756C>T	c.(3754-3756)ttC>ttT	p.F1252F	PLXNA4_ENST00000321063.4_Silent_p.F1252F			Q9HCM2	PLXA4_HUMAN	plexin A4	1252						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CGGCCACGATGAAAATGATGA	0.612000													6	23					0	0	1	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3391322	3391322	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3391322C>T	ENST00000378378.4	+	9	1761	c.1356C>T	c.(1354-1356)agC>agT	p.S452S	ARHGEF16_ENST00000413250.2_Silent_p.S156S|ARHGEF16_ENST00000378371.2_Silent_p.S164S|ARHGEF16_ENST00000378373.1_Silent_p.S164S	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	452	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		AGGCTGCCAGCCGTGCACTGA	0.632000													14	78					0	0	1	0	0
PRRX1	5396	broad.mit.edu	37	1	170688895	170688895	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:170688895G>A	ENST00000239461.6	+	2	583	c.270G>A	c.(268-270)aaG>aaA	p.K90K	PRRX1_ENST00000497230.2_Silent_p.K90K|PRRX1_ENST00000367760.3_Silent_p.K90K	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	90						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AAGAAAAAAAGAAGAGAAAGC	0.433000													6	27					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106121808	106121808	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106121808G>A	ENST00000369704.3	+	3	453	c.319G>A	c.(319-321)Gac>Aac	p.D107N	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	107										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GAAGATGGTGGACTCAGCCTA	0.458000													17	49					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2931166	2931166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:2931166C>T	ENST00000381130.2	+	3	293	c.293C>T	c.(292-294)aCt>aTt	p.T98I		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	98						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AATGAAACGACTTTTGCCAAG	0.552000													46	28					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117791663	117791663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117791663C>T	ENST00000350763.4	-	25	6556	c.6145G>A	c.(6145-6147)Gac>Aac	p.D2049N	TNC_ENST00000341037.4_Missense_Mutation_p.D1867N|TNC_ENST00000542877.1_Missense_Mutation_p.D1686N|TNC_ENST00000340094.3_Missense_Mutation_p.D1685N|TNC_ENST00000537320.1_Missense_Mutation_p.D1412N|TNC_ENST00000535648.1_Missense_Mutation_p.D1594N|TNC_ENST00000423613.2_Missense_Mutation_p.D1776N|TNC_ENST00000345230.3_Missense_Mutation_p.D1412N|TNC_ENST00000346706.3_Missense_Mutation_p.D1503N	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2049	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TCTCTGCGGTCCCCAAATCCA	0.468000													25	88					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39799066	39799066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39799066C>T	ENST00000248668.4	-	2	1522	c.1523G>A	c.(1522-1524)cGa>cAa	p.R508Q		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	508	Fibronectin type-III.					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GCCCACCACTCGCGTTGCCGG	0.677000													7	19					0	0	1	0	0
GBA	2629	broad.mit.edu	37	1	155207230	155207230	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155207230G>A	ENST00000428024.2	-	6	1142	c.640C>T	c.(640-642)Cgt>Tgt	p.R214C	GBA_ENST00000427500.2_Missense_Mutation_p.R252C|GBA_ENST00000368373.3_Missense_Mutation_p.R301C|GBA_ENST00000327247.5_Missense_Mutation_p.R301C|GBA_ENST00000536770.1_Missense_Mutation_p.R188C	NM_001171811.1	NP_001165282.1	P04062	GLCM_HUMAN	glucosidase, beta, acid	301					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	26	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	CCTAGGTCACGGGCAATGAAG	0.572000									Gaucher disease type I				12	64					0	0	1	0	0
ELOVL4	6785	broad.mit.edu	37	6	80634670	80634670	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:80634670C>T	ENST00000369816.4	-	3	668	c.369_splice	c.e3+1	p.R123_splice		NM_022726.3	NP_073563.1	Q9GZR5	ELOV4_HUMAN	ELOVL fatty acid elongase 4	123					fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	TGTACTTACCCTGACTTCATG	0.303000													18	34					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8176468	8176468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:8176468G>A	ENST00000520004.1	-	6	3681	c.3417C>T	c.(3415-3417)atC>atT	p.I1139I	SGK223_ENST00000330777.4_Silent_p.I1139I			Q86YV5	SG223_HUMAN		1139	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity										CCCGGTGGATGATCCCGTGCT	0.741000													14	160					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814675	106814675	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106814675G>A	ENST00000407775.2	+	8	2615	c.2365G>A	c.(2365-2367)Gat>Aat	p.D789N	ZFPM2_ENST00000520492.1_Missense_Mutation_p.D657N|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.D520N|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.D657N|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	789					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CCCAAGATGTGATATCTTTCC	0.438000													12	26					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60557969	60557969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60557969G>A	ENST00000308287.1	+	2	257	c.161G>A	c.(160-162)aGc>aAc	p.S54N		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	54						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						CAGAAGAAGAGCAGCCTTCTT	0.632000													23	63					0	0	1	0	0
MPP4	58538	broad.mit.edu	37	2	202552063	202552063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202552063G>A	ENST00000409474.3	-	5	518	c.311C>T	c.(310-312)tCc>tTc	p.S104F	MPP4_ENST00000447335.2_Missense_Mutation_p.S104F|MPP4_ENST00000409143.1_Intron|MPP4_ENST00000396886.3_Missense_Mutation_p.S104F|MPP4_ENST00000359962.5_Missense_Mutation_p.S104F|MPP4_ENST00000315506.7_Missense_Mutation_p.S104F|MPP4_ENST00000428900.2_Missense_Mutation_p.S104F	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	104	L27 2.					cytoplasm	protein binding			kidney(1)|lung(11)	12						GATCTCAGGGGAAGTAGGGGT	0.413000													3	9					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43766210	43766210	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43766210G>A	ENST00000244293.7	-	3	577	c.511C>T	c.(511-513)Cct>Tct	p.P171S	PSG9_ENST00000443718.3_Intron|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000270077.3_Missense_Mutation_p.P171S|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000593948.1_Missense_Mutation_p.P171S|PSG9_ENST00000291752.5_Intron			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	171	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGAGTCTCAGGATCACAGATT	0.532000													111	275					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463882	25463882	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25463882C>T	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						ATGCTGGGATCCCAGGGTCCC	0.522000													76	178					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44371558	44371558	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44371558C>T	ENST00000371477.3	+	6	851	c.552C>T	c.(550-552)gcC>gcT	p.A184A		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	184					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTCTTGCTGCCCTCCAAAAAA	0.348000													22	59					0	0	1	0	0
MLYCD	23417	broad.mit.edu	37	16	83948952	83948952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:83948952C>T	ENST00000262430.4	+	5	1359	c.1340C>T	c.(1339-1341)tCc>tTc	p.S447F	RP11-505K9.4_ENST00000561562.1_RNA	NM_012213.2	NP_036345.2	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase	447					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						ATCACCGGCTCCTGCGGCCTG	0.627000													26	61					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153077667	153077667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153077667G>A	ENST00000285900.5	+	9	1541	c.1198G>A	c.(1198-1200)Gat>Aat	p.D400N	GRIA1_ENST00000518783.1_Missense_Mutation_p.D410N|GRIA1_ENST00000521843.2_Missense_Mutation_p.D331N|GRIA1_ENST00000340592.5_Missense_Mutation_p.D400N|GRIA1_ENST00000448073.4_Missense_Mutation_p.D410N|GRIA1_ENST00000518142.1_Missense_Mutation_p.D320N	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	400					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGCTGGGGGCGATAATTCAAG	0.478000													16	46					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183675836	183675836	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183675836C>T	ENST00000511685.1	+	22	4439	c.4316C>T	c.(4315-4317)tCc>tTc	p.S1439F	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.S1439F					teneurin transmembrane protein 3									p.S1439F(1)									GGAGAAATCTCCTTAGTGGCC	0.468000													16	39					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94224659	94224659	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94224659G>A	ENST00000515393.1	-	12	1857	c.1858C>T	c.(1858-1860)Cac>Tac	p.H620Y	MCTP1_ENST00000312216.8_Missense_Mutation_p.H399Y|MCTP1_ENST00000429576.2_Missense_Mutation_p.H353Y|MCTP1_ENST00000505078.1_Missense_Mutation_p.H136Y|MCTP1_ENST00000505208.1_Missense_Mutation_p.H399Y	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	620	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TTCAGGTTGTGAAATATCCTC	0.433000													37	75					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108313328	108313328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:108313328C>T	ENST00000370056.4	-	6	852	c.578G>A	c.(577-579)cGa>cAa	p.R193Q	VAV3_ENST00000527011.1_Missense_Mutation_p.R193Q|VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000371846.4_Missense_Mutation_p.R128Q	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	193	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity	p.R193Q(2)		NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		ACAACAACTTCGTATATCATT	0.299000													30	132					0	0	1	0	0
IFNLR1	163702	broad.mit.edu	37	1	24483700	24483700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24483700C>T	ENST00000327535.1	-	7	1495	c.1483G>A	c.(1483-1485)Gat>Aat	p.D495N	IFNLR1_ENST00000374421.3_Missense_Mutation_p.D466N|IFNLR1_ENST00000327575.2_3'UTR	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1																		CTGCCCGCATCGCTGTCCTCA	0.627000													11	57					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300147	18300147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:18300147G>A	ENST00000441493.2	-	26	5632	c.5280C>T	c.(5278-5280)tgC>tgT	p.C1760C		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1760						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GGGTGCTGGGGCAGGACTTGT	0.637000													15	17					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52604148	52604148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52604148C>T	ENST00000521776.2	+	2	1941	c.1208C>T	c.(1207-1209)tCt>tTt	p.S403F		NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	403					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		CATGAGGTTTCTGCAAGTGAG	0.498000													25	75					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18736157	18736157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18736157C>T	ENST00000513874.1	-	12	1685	c.1546G>A	c.(1546-1548)Gtg>Atg	p.V516M	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	516										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						CCGCTCTTCACTGTGGCCAGA	0.607000													21	53					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88958337	88958337	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:88958337C>T	ENST00000268679.4	-	5	1060	c.664G>A	c.(664-666)Gag>Aag	p.E222K	CBFA2T3_ENST00000448839.1_Missense_Mutation_p.E146K|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.E197K|CBFA2T3_ENST00000360302.2_Missense_Mutation_p.E136K|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.E136K	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	222	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).|TAFH.				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		TTGGTGGCCTCCTGAAGCTTG	0.587000			T	RUNX1	AML								10	30					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47500966	47500966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47500966C>T	ENST00000285039.7	-	10	1375	c.1076G>A	c.(1075-1077)aGc>aAc	p.S359N		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	359	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GCAGAAGTTGCTTAGGTATAC	0.592000													41	95					0	0	1	0	0
RHCE	6006	broad.mit.edu	37	1	25735272	25735272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:25735272G>A	ENST00000349320.3	-	4	577	c.189C>T	c.(187-189)ttC>ttT	p.F63F	RHCE_ENST00000413854.1_Silent_p.F79F|RHCE_ENST00000425135.1_Silent_p.F79F|RHCE_ENST00000495048.1_5'UTR|RHCE_ENST00000243186.6_Silent_p.F79F|RHCE_ENST00000340849.4_Silent_p.F79F|RHCE_ENST00000349438.4_Silent_p.F79F|RHCE_ENST00000294413.7_Silent_p.F79F|RHCE_ENST00000346452.4_Silent_p.F79F|RHCE_ENST00000455194.1_Silent_p.F79F|RHCE_ENST00000374352.2_Silent_p.F63F			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	79						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		TGAAGAGGTTGAAGGCCACAC	0.597000													18	48					0	0	1	0	0
GFOD1	54438	broad.mit.edu	37	6	13365806	13365806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13365806G>A	ENST00000379287.3	-	2	1006	c.342C>T	c.(340-342)ctC>ctT	p.L114L	GFOD1_ENST00000379284.1_Silent_p.L11L	NM_018988.3	NP_061861.1	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain containing 1	114						extracellular region	binding|oxidoreductase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)	18	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			TGATGCTCATGAGCTTGGGGT	0.652000													49	114					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73442842	73442842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:73442842C>T	ENST00000377110.2	-	6	1137	c.894G>A	c.(892-894)ggG>ggA	p.G298G	TRPM3_ENST00000396280.5_Silent_p.G145G|TRPM3_ENST00000357533.2_Silent_p.G300G|TRPM3_ENST00000377111.2_Silent_p.G298G|TRPM3_ENST00000377101.1_Silent_p.G145G|TRPM3_ENST00000408909.2_Silent_p.G145G|TRPM3_ENST00000360823.2_Silent_p.G145G|TRPM3_ENST00000361823.5_Silent_p.G145G|TRPM3_ENST00000377106.1_Silent_p.G145G|TRPM3_ENST00000396285.1_Silent_p.G145G|TRPM3_ENST00000423814.3_Silent_p.G300G|TRPM3_ENST00000358082.3_Silent_p.G145G|TRPM3_ENST00000377105.1_Silent_p.G145G|TRPM3_ENST00000396283.1_Silent_p.G145G|TRPM3_ENST00000396292.4_Silent_p.G145G	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	298						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TTCCAGTGGTCCCGTTGTCAG	0.483000													52	116					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61264576	61264576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61264576C>T	ENST00000344731.5	+	8	1257	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	SERPINB13_ENST00000269489.5_Silent_p.F333F	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	385					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						TCCTCTTCTTCGGCAGATTTT	0.423000													47	97					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294158	25294158	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25294158G>A	ENST00000400358.4	+	19	2299	c.2242G>A	c.(2242-2244)Gtg>Atg	p.V748M	SGSM1_ENST00000400359.4_Missense_Mutation_p.V803M	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	803	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						CACCCCCACGGTGCTGCGACC	0.632000													13	64					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27687295	27687295	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27687295G>A	ENST00000438700.3	-	4	2349	c.2232C>T	c.(2230-2232)atC>atT	p.I744I		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	744					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GGGAAGAAATGATTTCATTTG	0.308000													16	42					0	0	1	0	0
GPX3	2878	broad.mit.edu	37	5	150407677	150407677	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150407677G>A	ENST00000388825.4	+	5	759	c.667G>A	c.(667-669)Gtc>Atc	p.V223I	GPX3_ENST00000517973.1_3'UTR	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	223					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	AGCCCTGGGGGTCAAGAGGAA	0.562000													3	4					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122002628	122002628	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122002628G>A	ENST00000498619.1	+	7	2295	c.1857G>A	c.(1855-1857)acG>acA	p.T619T	CASR_ENST00000296154.5_Silent_p.T609T|CASR_ENST00000490131.1_Silent_p.T609T	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	609					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGTCGTGGACGGAGCCCTTTG	0.527000													14	56					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149263075	149263075	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149263075G>A	ENST00000255266.5	-	17	2171	c.2052C>T	c.(2050-2052)atC>atT	p.I684I		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	684					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ACTGATCCACGATCTTTTGGA	0.448000													17	41					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131849943	131849943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131849943C>T	ENST00000359827.3	-	23	5265	c.4303G>A	c.(4303-4305)Gag>Aag	p.E1435K	PLXNA4_ENST00000321063.4_Missense_Mutation_p.E1435K			Q9HCM2	PLXA4_HUMAN	plexin A4	1435						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						AGCATCTTCTCAGCCACTGAC	0.527000													30	56					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181721295	181721295	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181721295G>A	ENST00000526775.1	+	26	3856	c.3691G>A	c.(3691-3693)Gac>Aac	p.D1231N	CACNA1E_ENST00000367567.4_Missense_Mutation_p.D857N|CACNA1E_ENST00000358338.5_Missense_Mutation_p.D1182N|CACNA1E_ENST00000367570.1_Missense_Mutation_p.D1250N|CACNA1E_ENST00000360108.3_Missense_Mutation_p.D1231N|CACNA1E_ENST00000367573.2_Missense_Mutation_p.D1250N|CACNA1E_ENST00000357570.5_Missense_Mutation_p.D1201N	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1250	Poly-Val.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CAAAGGACGGGACATCAAGAC	0.478000													26	73					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6553068	6553068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6553068G>A	ENST00000263125.5	-	3	306	c.207C>T	c.(205-207)gtC>gtT	p.V69V	PRKCQ_ENST00000397176.2_Silent_p.V69V|PRKCQ_ENST00000539722.1_5'UTR	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	69	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TGATCTGCATGACTCTTCCCT	0.493000													52	110					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50611658	50611658	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50611658G>A	ENST00000444124.2	-	2	326	c.126C>T	c.(124-126)atC>atT	p.I42I	DDC_ENST00000357936.5_Silent_p.I42I|DDC_ENST00000380984.4_Silent_p.I42I|DDC_ENST00000431062.1_Silent_p.I42I|DDC_ENST00000426377.1_Silent_p.I42I	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	42					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CAGCGGCAGGGATCAGCGGCC	0.562000													92	118					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9449315	9449315	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9449315G>A	ENST00000378501.2	+	32	3325	c.3310G>A	c.(3310-3312)Gaa>Aaa	p.E1104K	PLCB4_ENST00000414679.2_Missense_Mutation_p.E1116K|PLCB4_ENST00000378493.1_Missense_Mutation_p.E1104K|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.E1104K|PLCB4_ENST00000378473.3_Missense_Mutation_p.E1116K|PLCB4_ENST00000334005.3_Missense_Mutation_p.E1104K	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	1104					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AGCAGAACGGGAAAGGTAAGT	0.418000													32	68					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380486	56380486	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56380486G>A	ENST00000526538.1	-	1	492	c.493C>T	c.(493-495)Cac>Tac	p.H165Y		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						AAGGATAAGTGAAAGGTTAGC	0.463000													15	48					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400656	89400656	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89400656C>T	ENST00000439576.2	+	12	5214	c.4840C>T	c.(4840-4842)Cta>Tta	p.L1614L	ACAN_ENST00000559004.1_Silent_p.L1614L|ACAN_ENST00000561243.1_Silent_p.L1614L|ACAN_ENST00000352105.7_Silent_p.L1614L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1614					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TTCTGGAACTCTAGGAAGTGG	0.547000													45	177					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86919144	86919144	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86919144T>C	ENST00000370565.4	+	13	2410	c.2248T>C	c.(2248-2250)Ttt>Ctt	p.F750L	CLCA2_ENST00000498802.1_3'UTR	NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	750					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AGGAGGCTCCTTTTCAGTGCT	0.488000													7	110					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126882788	126882788	+	Silent	SNP	G	G	A	rs146190169	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:126882788G>A	ENST00000339582.2	-	2	1279	c.471C>T	c.(469-471)tcC>tcT	p.S157S	GRM8_ENST00000405249.1_Silent_p.S157S|GRM8_ENST00000444921.2_Silent_p.S157S|GRM8_ENST00000358373.3_Silent_p.S157S			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	157					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TGATGGACACGGAGCTTGCTG	0.428000										HNSCC(24;0.065)			13	113					0	0	1	0	0
PRKCE	5581	broad.mit.edu	37	2	46237647	46237647	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:46237647C>T	ENST00000306156.3	+	10	1755	c.1428C>T	c.(1426-1428)ttC>ttT	p.F476F	PRKCE_ENST00000394874.1_Silent_p.F199F	NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	476	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity	p.F476L(1)	MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			ACTGCTGCTTCCAGACCAAGG	0.473000													10	67					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166891946	166891946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:166891946C>T	ENST00000271417.3	-	8	1150	c.1095G>A	c.(1093-1095)ggG>ggA	p.G365G	ILDR2_ENST00000528703.1_Silent_p.G306G|ILDR2_ENST00000469934.2_Silent_p.G365G|ILDR2_ENST00000529071.1_Silent_p.G346G|ILDR2_ENST00000525740.1_Silent_p.G238G|ILDR2_ENST00000526687.1_Silent_p.G257G|ILDR2_ENST00000529387.1_Intron	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	365						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						TCTCCAAGTCCCCAGACACAG	0.532000													36	198					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833477	61833477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61833477C>T	ENST00000280772.1	-	37	7353	c.7162G>A	c.(7162-7164)Gaa>Aaa	p.E2388K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2388					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGACCCTGTTCCTCTGAACAA	0.398000													79	32					0	0	1	0	0
ICAM1	3383	broad.mit.edu	37	19	10395216	10395216	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10395216C>T	ENST00000264832.3	+	5	1388	c.1063C>T	c.(1063-1065)Cag>Tag	p.Q355*	ICAM1_ENST00000423829.2_Nonsense_Mutation_p.Q133*|CTD-2369P2.5_ENST00000592893.1_RNA	NM_000201.2	NP_000192.2	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1	355	Ig-like C2-type 4.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	CCCGAGGGCCCAGCTCCTGCT	0.642000													12	95					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124371784	124371784	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124371784G>A	ENST00000409039.3	+	51	8590	c.8565G>A	c.(8563-8565)gcG>gcA	p.A2855A		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2855	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGAACAAAGCGATGATCTTTC	0.542000													15	26					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303925	151303925	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151303925G>A	ENST00000370323.4	-	4	484	c.168C>T	c.(166-168)tcC>tcT	p.S56S	MAGEA10_ENST00000244096.3_Silent_p.S56S|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	56	Poly-Ser.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					aggaggaagaggaggaggagg	0.557000													19	40					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26158069	26158069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:26158069C>T	ENST00000325250.1	+	2	1154	c.967C>T	c.(967-969)Cat>Tat	p.H323Y		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	323							protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						AGCCAGGGCTCATACTGCTGC	0.502000													7	9					0	0	1	0	0
ADAD2	161931	broad.mit.edu	37	16	84224922	84224922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84224922C>T	ENST00000268624.3	+	1	179	c.86C>T	c.(85-87)cCc>cTc	p.P29L	ADAD2_ENST00000315906.5_Missense_Mutation_p.P29L|ADAD2_ENST00000567413.1_3'UTR	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	29					RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						AGCCCCCAGCCCCGCCCCTGG	0.736000													7	9					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37325463	37325463	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37325463G>A	ENST00000262825.5	+	5	628	c.411G>A	c.(409-411)agG>agA	p.R137R	CSF2RB_ENST00000536485.1_Silent_p.R78R|CSF2RB_ENST00000406230.1_Silent_p.R137R|CSF2RB_ENST00000403662.3_Silent_p.R137R	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	137	Fibronectin type-III 1.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CTGAGCCCAGGGACCTGCAGA	0.642000													52	143					0	0	1	0	0
RFX1	5989	broad.mit.edu	37	19	14094343	14094343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14094343G>A	ENST00000254325.4	-	3	618	c.384C>T	c.(382-384)acC>acT	p.T128T		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	128					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			TAGGAACGCCGGTCTGGCTGG	0.701000													5	14					0	0	1	0	0
OR13J1	392309	broad.mit.edu	37	9	35869520	35869520	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35869520C>T	ENST00000377981.2	-	1	941	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			CCTCCTTGTTCCTCAGGCTGT	0.592000													13	42					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82585473	82585473	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82585473C>T	ENST00000423517.2	-	5	5133	c.4796G>A	c.(4795-4797)gGa>gAa	p.G1599E	PCLO_ENST00000333891.8_Missense_Mutation_p.G1599E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1530					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTGCCTTTTCCCTTTGTTTC	0.428000													51	172					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886856	23886856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23886856G>A	ENST00000355349.3	-	31	4371	c.4209C>T	c.(4207-4209)gcC>gcT	p.A1403A		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1403					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CAGCCTCCACGGCCTCCTCAG	0.612000													33	53					0	0	1	0	0
TBCA	6902	broad.mit.edu	37	5	76989169	76989169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76989169G>A	ENST00000520039.1	-	2	78	c.62C>T	c.(61-63)tCc>tTc	p.S21F	TBCA_ENST00000517881.1_5'UTR|TBCA_ENST00000520361.1_Intron|TBCA_ENST00000380377.4_Silent_p.I56I|TBCA_ENST00000522370.1_Silent_p.I32I|TBCA_ENST00000306388.6_Silent_p.I56I|TBCA_ENST00000518338.2_Silent_p.I79I|TBCA_ENST00000517679.1_Silent_p.I67I			O75347	TBCA_HUMAN	tubulin folding cofactor A	0					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway|tubulin complex assembly	cytoplasm|microtubule	chaperone binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)|ovary(1)	5		all_lung(232;0.000511)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;1.02e-49)|Epithelial(54;1.05e-44)|all cancers(79;4.08e-40)		ATTCTTGTAGGATCTCTGCCT	0.423000													6	47					0	0	1	0	0
TRBV6-5	28602	broad.mit.edu	37	7	142180727	142180727	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142180727C>T	ENST00000390368.2	-	0	197																											GGTTCATATCCTGGGCACACT	0.512000													29	465					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096388	167096388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167096388G>A	ENST00000361200.2	+	6	2186	c.2020G>A	c.(2020-2022)Gac>Aac	p.D674N	DUSP27_ENST00000271385.5_Missense_Mutation_p.D674N|DUSP27_ENST00000443333.1_Missense_Mutation_p.D674N|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	674					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CGCTGATGGGGACACGACGTC	0.632000													7	45					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367888	107367888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107367888G>A	ENST00000542196.1	-	1	63	c.21C>T	c.(19-21)acC>acT	p.T7T		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CCACCAGAATGGTGTGGTTTT	0.368000													22	88					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072540	17072540	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17072540C>T	ENST00000359963.3	-	1	1160	c.901G>A	c.(901-903)Gag>Aag	p.E301K		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	301					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGGGTCTCCTCGTCGACCTCC	0.493000													81	168					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37407121	37407121	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37407121G>A	ENST00000403892.3	-	2	1575	c.841C>T	c.(841-843)Cgc>Tgc	p.R281C	TST_ENST00000249042.3_Missense_Mutation_p.R281C	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	281	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						GGGGCCCGGCGAAACCACTCG	0.642000													46	93					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35833903	35833903	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:35833903G>A	ENST00000187397.4	+	19	2518	c.2062G>A	c.(2062-2064)Gga>Aga	p.G688R	ARPP21_ENST00000476052.1_3'UTR|ARPP21_ENST00000337271.5_Missense_Mutation_p.G669R|ARPP21_ENST00000444190.1_Missense_Mutation_p.G669R|ARPP21_ENST00000417925.1_Missense_Mutation_p.G689R|ARPP21_ENST00000458225.1_Missense_Mutation_p.G689R	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	688	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						TGGTCAACAGGGATTCCAAGG	0.468000													72	184					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	239990214	239990214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:239990214G>A	ENST00000345617.3	-	23	3616	c.2825C>T	c.(2824-2826)cCt>cTt	p.P942L	HDAC4_ENST00000543185.1_Missense_Mutation_p.P526L	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	942	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GCCCCCAAGAGGGGTGGGGTG	0.597000													16	46					0	0	1	0	0
TRAPPC2L	51693	broad.mit.edu	37	16	88925146	88925146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:88925146C>T	ENST00000561840.1	+	2	113	c.35C>T	c.(34-36)tCg>tTg	p.S12L	TRAPPC2L_ENST00000301021.3_Silent_p.V51V|TRAPPC2L_ENST00000564365.1_5'UTR|TRAPPC2L_ENST00000568583.1_Silent_p.V51V|TRAPPC2L_ENST00000567895.1_Silent_p.V21V|TRAPPC2L_ENST00000567312.1_Silent_p.V51V|TRAPPC2L_ENST00000565504.1_Silent_p.V51V			Q9UL33	TPC2L_HUMAN	trafficking protein particle complex 2-like	0					ER to Golgi vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm				lung(4)|pancreas(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(80;0.0477)		AGGCCCTGGTCGACCAGAGGG	0.577000													13	52					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848916	73848916	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73848916G>A	ENST00000523207.1	+	3	1914	c.1326G>A	c.(1324-1326)cgG>cgA	p.R442R		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	442					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CTCTTGAGCGGGCCAAAAGGA	0.453000													26	83					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060446	54060446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54060446C>T	ENST00000312233.2	-	3	696	c.130G>A	c.(130-132)Gaa>Aaa	p.E44K		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	44					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GAGCTGGGTTCGCTGCCCAGA	0.726000													3	16					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31155153	31155153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31155153G>A	ENST00000268281.4	-	7	784	c.726C>T	c.(724-726)gaC>gaT	p.D242D	PRSS36_ENST00000569305.1_Silent_p.D242D|PRSS36_ENST00000418068.2_Silent_p.D242D	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	242	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						GCCCCCCAGAGTCACCCTAGT	0.597000													6	53					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140407020	140407020	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140407020C>T	ENST00000286349.3	+	3	1687	c.1496C>T	c.(1495-1497)tCc>tTc	p.S499F		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	499						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AAGGTACGCTCCTCAGGGGAC	0.572000													24	50					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8987264	8987264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8987264C>T	ENST00000397910.4	-	68	42026	c.41823G>A	c.(41821-41823)atG>atA	p.M13941I	MUC16_ENST00000380951.5_Missense_Mutation_p.M582I	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13966	SEA 13.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CGGGTTGGCCCATGTCCGCCA	0.602000													9	41					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151751443	151751443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151751443G>A	ENST00000368822.1	-	6	1234	c.601C>T	c.(601-603)Cgg>Tgg	p.R201W	TDRKH_ENST00000458431.2_Missense_Mutation_p.R201W|TDRKH_ENST00000368823.1_Missense_Mutation_p.R197W|TDRKH_ENST00000440583.2_5'UTR|TDRKH_ENST00000368824.3_Missense_Mutation_p.R201W|TDRKH_ENST00000484421.1_5'UTR|TDRKH_ENST00000368825.3_Missense_Mutation_p.R156W|TDRKH_ENST00000368827.6_Missense_Mutation_p.R201W			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	201							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ATTCTCTTCCGAAGTTCTTCA	0.453000													31	95					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57641670	57641670	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57641670G>A	ENST00000254181.4	+	4	2081	c.1627G>A	c.(1627-1629)Gaa>Aaa	p.E543K	USP29_ENST00000598197.1_Missense_Mutation_p.E543K	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	543					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTATTGCAATGAAAGCACCAA	0.418000													77	171					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067224	9067224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9067224G>A	ENST00000397910.4	-	3	20425	c.20222C>T	c.(20221-20223)cCt>cTt	p.P6741L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6743	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCAAGAGGAGGACCTGTTCG	0.502000													68	200					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582174	82582174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82582174G>A	ENST00000423517.2	-	5	8432	c.8095C>T	c.(8095-8097)Cct>Tct	p.P2699S	PCLO_ENST00000333891.8_Missense_Mutation_p.P2699S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2630					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGCTCTGGAGGAATTGTTATG	0.403000													17	44					0	0	1	0	0
C1orf105	92346	broad.mit.edu	37	1	172425563	172425563	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:172425563G>A	ENST00000367727.4	+	4	405	c.207G>A	c.(205-207)agG>agA	p.R69R	C1orf105_ENST00000367726.1_Intron|C1orf105_ENST00000367725.4_Silent_p.R59R	NM_139240.3	NP_640333.3	O95561	CA105_HUMAN	chromosome 1 open reading frame 105	69										large_intestine(1)|lung(12)|prostate(1)|skin(1)	15						AGGCCAGGAGGAACCAGTGTG	0.532000													51	142					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027567	37027567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37027567C>T	ENST00000358047.3	+	1	1136	c.1084C>T	c.(1084-1086)Cgc>Tgc	p.R362C		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	362										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCCAGAGACTCGCGTATCTCC	0.647000													39	59					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065427	35065427	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35065427C>T	ENST00000382002.5	-	10	2059	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K	PRLR_ENST00000513753.1_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.E444K|PRLR_ENST00000511486.1_Missense_Mutation_p.E444K|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000310101.5_3'UTR|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	545					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTGGCATACTCCTTATTGTTC	0.478000													19	75					0	0	1	0	0
ECEL1	9427	broad.mit.edu	37	2	233346338	233346338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233346338C>T	ENST00000304546.1	-	14	2077	c.1867G>A	c.(1867-1869)Ggc>Agc	p.G623S	ECEL1_ENST00000409941.1_Missense_Mutation_p.G621S	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	623					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCATACTGGCCCCCTGTGGGC	0.652000													11	27					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50557805	50557805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50557805C>T	ENST00000267845.3	-	1	418	c.16G>A	c.(16-18)Gag>Aag	p.E6K	HDC_ENST00000543581.1_Missense_Mutation_p.E6K	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	6					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TCTCTGTACTCCTCAGGCTCC	0.617000													15	28					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70461449	70461449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:70461449C>T	ENST00000327305.6	-	6	1199	c.542G>A	c.(541-543)gGa>gAa	p.G181E	NETO1_ENST00000583169.1_Missense_Mutation_p.G181E|NETO1_ENST00000299430.2_Missense_Mutation_p.G180E	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	181	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CTCCACAATTCCTTCGGAACC	0.428000													34	65					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38051317	38051317	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:38051317C>T	ENST00000357436.4	+	18	2045	c.1732C>T	c.(1732-1734)Ccc>Tcc	p.P578S	Z83844.1_ENST00000456099.1_RNA|SH3BP1_ENST00000599616.1_Intron	NM_018957.3	NP_061830.3	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	578					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					CATGCCGCCCCCCCAGGTCTC	0.721000													8	14					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305062	61305062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61305062G>A	ENST00000341074.5	-	8	1179	c.1064C>T	c.(1063-1065)tCa>tTa	p.S355L	SERPINB4_ENST00000356424.6_Missense_Mutation_p.S303L	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TGAAGGAGATGATAATTCGAC	0.448000													42	107					0	0	1	0	0
CNIH3	149111	broad.mit.edu	37	1	224804900	224804900	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:224804900C>T	ENST00000272133.3	+	1	906	c.24C>T	c.(22-24)ttC>ttT	p.F8F		NM_152495.1	NP_689708.1	Q8TBE1	CNIH3_HUMAN	cornichon family AMPA receptor auxiliary protein 3	8					intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane				large_intestine(5)|lung(4)	9	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		TCGCTGCGTTCTGCTACATGC	0.597000													96	375					0	0	1	0	0
KATNAL1	84056	broad.mit.edu	37	13	30854256	30854256	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:30854256T>A	ENST00000380615.3	-	3	434	c.267A>T	c.(265-267)caA>caT	p.Q89H	KATNAL1_ENST00000380617.3_Missense_Mutation_p.Q89H	NM_032116.4	NP_115492.1	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	89						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|skin(1)|urinary_tract(3)	19		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		ATGGTTCATCTTGACAGGACA	0.393000													15	33					0	0	1	0	0
ANXA10	11199	broad.mit.edu	37	4	169049298	169049298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169049298G>A	ENST00000359299.3	+	2	268	c.82G>A	c.(82-84)Gga>Aga	p.G28R		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	28							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		AATGCTAGGAGGAGCACTCCA	0.368000													5	54					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113352931	113352931	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113352931C>T	ENST00000458497.1	+	11	2507	c.2228C>T	c.(2227-2229)gCc>gTc	p.A743V	ALPK1_ENST00000177648.9_Missense_Mutation_p.A743V|ALPK1_ENST00000504176.2_Missense_Mutation_p.A665V	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	743							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AAAGAAGAAGCCTTTGAAATA	0.468000													27	71					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145110780	145110780	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145110780G>A	ENST00000426825.1	-	16	2240	c.2159C>T	c.(2158-2160)tCc>tTc	p.S720F	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	720							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GGCCCCCACGGAGATGCAGAT	0.647000													3	12					0	0	1	0	0
CEACAM21	90273	broad.mit.edu	37	19	42085862	42085862	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42085862G>A	ENST00000407170.2	+	4	1010	c.197G>A	c.(196-198)tGg>tAg	p.W66*	CEACAM21_ENST00000401445.2_Nonsense_Mutation_p.W194*|CEACAM21_ENST00000482870.2_3'UTR|CEACAM21_ENST00000187608.9_Nonsense_Mutation_p.W194*			Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	194						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						AAGCTGTCCTGGTTTAACCAT	0.542000													7	25					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233749941	233749941	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233749941C>T	ENST00000366621.3	+	1	192	c.24C>T	c.(22-24)agC>agT	p.S8S		NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	8						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TGGCCGGCAGCTCGTGCGTGC	0.721000													7	20					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76471399	76471399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76471399C>T	ENST00000389840.5	-	54	8554	c.8430G>A	c.(8428-8430)caG>caA	p.Q2810Q	DNAH17_ENST00000585328.1_Silent_p.Q2819Q|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGAGGGTGATCTGAAACACGT	0.587000													26	99					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63517664	63517664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63517664C>T	ENST00000377819.5	+	4	2886	c.2732C>T	c.(2731-2733)cCa>cTa	p.P911L	RTN3_ENST00000354497.4_Missense_Mutation_p.P115L|RTN3_ENST00000537981.1_Missense_Mutation_p.P115L|RTN3_ENST00000356000.3_Missense_Mutation_p.P134L|RTN3_ENST00000540798.1_Missense_Mutation_p.P799L|RTN3_ENST00000339997.4_Missense_Mutation_p.P892L|RTN3_ENST00000341307.2_Missense_Mutation_p.P115L	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	911	Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						GAAGGCCATCCATTCAAGTGA	0.428000													7	17					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35945118	35945118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35945118G>A	ENST00000490799.1	-	9	1389	c.1036C>T	c.(1036-1038)Cct>Tct	p.P346S	SLC26A8_ENST00000355574.2_Missense_Mutation_p.P346S|SLC26A8_ENST00000394602.2_Missense_Mutation_p.P241S	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	346					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						GGTGTTACAGGAAGCAGAAAG	0.423000													23	85					0	0	1	0	0
PPP1R3D	5509	broad.mit.edu	37	20	58514657	58514657	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:58514657G>A	ENST00000370996.3	-	1	695	c.330C>T	c.(328-330)ggC>ggT	p.G110G	FAM217B_ENST00000358293.3_Intron	NM_006242.3	NP_006233.1	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	110					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|urinary_tract(1)	13	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			CCAGCTCCAAGCCCAGGGCGT	0.726000													10	25					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3687253	3687253	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3687253C>T	ENST00000344754.4	-	2	149	c.150G>A	c.(148-150)gaG>gaA	p.E50E	SIGLEC1_ENST00000202578.4_Silent_p.E50E	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	50	Ig-like V-type.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CGTCGGGCACCTCCACGTCGG	0.667000													3	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179469545	179469545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179469545C>T	ENST00000589042.1	-	281	54495	c.54271G>A	c.(54271-54273)Gat>Aat	p.D18091N	TTN_ENST00000342992.6_Missense_Mutation_p.D15523N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D9026N|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D9218N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D9151N|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D16450N|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16450	Fibronectin type-III 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACCATTATCAAGAGGGGCA	0.448000													26	56					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40760984	40760984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40760984C>T	ENST00000216194.7	+	12	1348	c.1292C>T	c.(1291-1293)gCc>gTc	p.A431V	ADSL_ENST00000342312.6_Intron|ADSL_ENST00000454266.2_Missense_Mutation_p.A445V	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase	431					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						CAGGTTGATGCCTACTTCAGT	0.488000													10	186					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26736598	26736598	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26736598G>A	ENST00000529632.2	+	10	2408	c.2212_splice	c.e10+1	p.E738_splice	SEZ6L_ENST00000343706.4_Splice_Site_p.E738_splice|SEZ6L_ENST00000360929.3_Splice_Site_p.E738_splice|SEZ6L_ENST00000404234.3_Splice_Site_p.E738_splice|SEZ6L_ENST00000248933.6_Splice_Site_p.E738_splice|SEZ6L_ENST00000402979.1_Splice_Site_p.E511_splice|SEZ6L_ENST00000403121.1_Splice_Site_p.E511_splice	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	738	CUB 3.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GAACTACATAGGTAGGTGTCT	0.428000													7	49					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328333	80328333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:80328333G>A	ENST00000358842.3	-	1	1039	c.1022C>T	c.(1021-1023)aCc>aTc	p.T341I		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	341					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						GTCTCCTGAGGTCTCTATAAT	0.438000													54	138					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	48994003	48994003	+	Missense_Mutation	SNP	T	T	C	rs146104899	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48994003T>C	ENST00000226432.4	+	4	590	c.407T>C	c.(406-408)cTa>cCa	p.L136P	CWH43_ENST00000513409.1_Missense_Mutation_p.L109P	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	136					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						CTTGTTGTTCTACGCATATGG	0.373000													26	69					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81647096	81647096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81647096C>T	ENST00000548058.1	+	14	2640	c.1730C>T	c.(1729-1731)tCc>tTc	p.S577F	ACSS3_ENST00000548324.1_Missense_Mutation_p.S259F|ACSS3_ENST00000261206.3_Missense_Mutation_p.S576F			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	577						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TCAATCCTTTCCCATGGTACC	0.363000													26	199					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47463708	47463708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47463708G>A	ENST00000398879.1	-	10	830	c.464C>T	c.(463-465)tCc>tTc	p.S155F	TNS3_ENST00000311160.9_Missense_Mutation_p.S155F|TNS3_ENST00000442536.2_Missense_Mutation_p.S155F|TNS3_ENST00000458317.2_Missense_Mutation_p.S155F|TNS3_ENST00000355730.3_Missense_Mutation_p.S155F			Q68CZ2	TENS3_HUMAN	tensin 3	155	Phosphatase tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CCGTTTTTGGGAAGGCTGCAT	0.433000													18	77					0	0	1	0	0
TMEM117	84216	broad.mit.edu	37	12	44782277	44782277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:44782277C>T	ENST00000266534.3	+	8	1494	c.1367C>T	c.(1366-1368)tCa>tTa	p.S456L	TMEM117_ENST00000551577.1_3'UTR|TMEM117_ENST00000536799.1_Missense_Mutation_p.S352L|TMEM117_ENST00000546978.1_3'UTR	NM_032256.1	NP_115632.1	Q9H0C3	TM117_HUMAN	transmembrane protein 117	456						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		ACCCAGGCTTCAGTAGAAGAC	0.443000													60	95					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432190	140432190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140432190G>A	ENST00000306549.3	+	1	1212	c.1135G>A	c.(1135-1137)Gga>Aga	p.G379R		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		379	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATTCGAGTGGGAGGAAAAGT	0.498000													29	53					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3638665	3638665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3638665C>T	ENST00000378295.4	+	5	665	c.510C>T	c.(508-510)ccC>ccT	p.P170P	TP73_ENST00000378285.1_Silent_p.P121P|TP73_ENST00000604479.1_Silent_p.P170P|TP73_ENST00000378288.4_Silent_p.P121P|TP73_ENST00000354437.4_Silent_p.P170P|TP73_ENST00000603362.1_Silent_p.P170P|TP73_ENST00000378290.4_Silent_p.P99P|TP73_ENST00000357733.3_Silent_p.P170P|TP73_ENST00000378280.1_Silent_p.P121P|TP73_ENST00000604074.1_Silent_p.P170P|TP73_ENST00000346387.4_Silent_p.P170P	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	170	DNA-binding (Potential).|Poly-Pro.				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CCCCGCCACCCCCAGGCACCG	0.617000													24	79					0	0	1	0	0
GCNT3	9245	broad.mit.edu	37	15	59911343	59911343	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:59911343C>T	ENST00000396065.1	+	3	1354	c.906C>T	c.(904-906)tcC>tcT	p.S302S	GCNT3_ENST00000560585.1_Silent_p.S302S	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	302					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TTGTGGCTTCCCGAGATTTCG	0.433000													70	167					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15807281	15807281	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15807281G>A	ENST00000550308.1	+	12	1736	c.1356G>A	c.(1354-1356)ggG>ggA	p.G452G	CYP4F12_ENST00000324632.9_Silent_p.G452G	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ACAGCAAGGGGAGGTCACCTC	0.552000													49	170					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202617958	202617958	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202617958G>A	ENST00000264276.6	-	7	2020	c.1648C>T	c.(1648-1650)Ccg>Tcg	p.P550S		NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	550					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						ACACACAACGGTTGAAGCCTT	0.413000													34	70					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68405287	68405287	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68405287C>T	ENST00000219334.5	-	3	1401	c.798G>A	c.(796-798)caG>caA	p.Q266Q	SMPD3_ENST00000563226.1_Silent_p.Q266Q|SMPD3_ENST00000568373.1_Silent_p.Q266Q	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	266					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CGTTCCTGGCCTGGCCCCCAG	0.716000													4	30					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53216853	53216853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53216853G>A	ENST00000330553.5	-	7	1348	c.1314C>T	c.(1312-1314)gcC>gcT	p.A438A		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	438	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCACGTCCAGGGCCAGCTTGA	0.632000													28	71					0	0	1	0	0
ZNF768	79724	broad.mit.edu	37	16	30536515	30536515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30536515G>A	ENST00000380412.5	-	2	1121	c.946C>T	c.(946-948)Ccc>Tcc	p.P316S	ZNF768_ENST00000562803.1_Missense_Mutation_p.P285S	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	316					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						CATTTGTAGGGCCGCTCGCCA	0.607000													6	76					0	0	1	0	0
SNTB2	6645	broad.mit.edu	37	16	69317986	69317986	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:69317986C>T	ENST00000336278.4	+	5	1222	c.1184C>T	c.(1183-1185)tCc>tTc	p.S395F		NM_006750.3	NP_006741.1	Q13425	SNTB2_HUMAN	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	395	PH 2.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)		CGATCCCCCTCCCTTGGATCT	0.483000													28	123					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233313560	233313560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233313560C>T	ENST00000258229.8	-	17	3495	c.3261G>A	c.(3259-3261)atG>atA	p.M1087I	PCNXL2_ENST00000488780.2_Missense_Mutation_p.M220I	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1087						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CTGAATCTTTCATCTTCTTGG	0.463000													15	33					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416375	29416375	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29416375C>T	ENST00000389048.3	-	29	5484	c.4578G>A	c.(4576-4578)gaG>gaA	p.E1526E	ALK_ENST00000431873.1_Silent_p.E356E	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1526					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGTCGTGTGGCTCCTTCTTTG	0.547000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				91	242					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308496	248308496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248308496G>A	ENST00000366476.1	+	1	47	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ATCCTCCTGGGAATCTTCAAT	0.443000													111	265					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953626	140953626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140953626C>T	ENST00000277549.5	+	31	4726	c.2157C>T	c.(2155-2157)atC>atT	p.I719I	CACNA1B_ENST00000277551.2_Silent_p.I1523I|CACNA1B_ENST00000371372.1_Silent_p.I1523I|CACNA1B_ENST00000371363.1_Silent_p.I1523I|CACNA1B_ENST00000371355.4_Silent_p.I1524I|CACNA1B_ENST00000371357.1_Silent_p.I1524I			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1523					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TGAAGATCATCGCCTTTGGGG	0.502000													4	12					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21120193	21120193	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21120193C>T	ENST00000377122.4	-	16	1999	c.1603G>A	c.(1603-1605)Gga>Aga	p.G535R	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	535					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ACTTGCATTCCTTTCCCTTTA	0.368000													6	74					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645218	52645218	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:52645218G>A	ENST00000395961.3	-	4	602	c.436C>T	c.(436-438)Ccg>Tcg	p.P146S	BCAS1_ENST00000371440.3_Missense_Mutation_p.P146S|BCAS1_ENST00000371435.2_Missense_Mutation_p.P146S|BCAS1_ENST00000411563.1_Missense_Mutation_p.P49S	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	146						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TCCTGCCCCGGTCCAGCTGCC	0.592000													27	62					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89650480	89650480	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89650480C>T	ENST00000268720.5	+	6	832	c.702C>T	c.(700-702)ctC>ctT	p.L234L	CPNE7_ENST00000319518.8_Silent_p.L159L	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	234					lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		ACGTGGAGCTCTCCTTCCGGG	0.687000													9	44					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26414504	26414504	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26414504T>A	ENST00000265944.5	+	19	2247	c.2081T>A	c.(2080-2082)aTt>aAt	p.I694N	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	694	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GTCAATTGCATTAACAGTTTG	0.348000													13	139					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	628613	628613	+	Missense_Mutation	SNP	G	G	A	rs140444984		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:628613G>A	ENST00000255622.6	+	2	659	c.616G>A	c.(616-618)Gaa>Aaa	p.E206K	PDE6B_ENST00000496514.1_Missense_Mutation_p.E206K	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	206	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						CAGCGAAGACGAAGATGTGAG	0.602000													19	45					0	0	1	0	0
AMPD2	271	broad.mit.edu	37	1	110168355	110168355	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110168355C>T	ENST00000256578.3	+	3	816	c.456C>T	c.(454-456)ccC>ccT	p.P152P	AMPD2_ENST00000342115.4_Silent_p.P71P|AMPD2_ENST00000393688.3_Silent_p.P33P|AMPD2_ENST00000526301.1_3'UTR|AMPD2_ENST00000358729.4_Silent_p.P77P|AMPD2_ENST00000528667.1_Silent_p.P152P|AMPD2_ENST00000528454.1_Silent_p.P34P	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	152					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		AGGAGAGCCCCATTGAACAGC	0.642000													20	71					0	0	1	0	0
AGTRAP	57085	broad.mit.edu	37	1	11808498	11808498	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11808498C>T	ENST00000376637.3	+	3	285	c.160C>T	c.(160-162)Ctt>Ttt	p.L54F	AGTRAP_ENST00000400895.2_Missense_Mutation_p.L98F|AGTRAP_ENST00000510878.1_Missense_Mutation_p.S30F|AGTRAP_ENST00000376629.4_Silent_p.I65I|AGTRAP_ENST00000452018.2_Missense_Mutation_p.L98F|AGTRAP_ENST00000314340.5_Silent_p.I65I|AGTRAP_ENST00000376627.2_Missense_Mutation_p.L110F|AGTRAP_ENST00000491346.1_3'UTR	NM_001040195.1	NP_001035285.1	Q6RW13	ATRAP_HUMAN	angiotensin II receptor-associated protein	0						cytoplasmic vesicle membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding		AGTRAP/BRAF(2)	endometrium(1)|lung(3)|prostate(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.46e-06)|COAD - Colon adenocarcinoma(227;0.000256)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCCACCATCTTCCTGGACA	0.627000													21	57					0	0	1	0	0
TMEM178A	130733	broad.mit.edu	37	2	39931233	39931233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:39931233G>A	ENST00000281961.2	+	2	469	c.413G>A	c.(412-414)cGa>cAa	p.R138Q	TMEM178A_ENST00000482239.1_3'UTR	NM_152390.2	NP_689603.2			transmembrane protein 178A																		ATTGCGCAGCGATGCACGGCC	0.448000													11	42					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70938399	70938399	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70938399T>C	ENST00000334414.6	-	22	5476	c.5432A>G	c.(5431-5433)aAg>aGg	p.K1811R	PTPRB_ENST00000550857.1_Missense_Mutation_p.K1503R|PTPRB_ENST00000451516.2_Missense_Mutation_p.K1503R|PTPRB_ENST00000550358.1_Missense_Mutation_p.K1723R|PTPRB_ENST00000538708.1_Missense_Mutation_p.K1503R|PTPRB_ENST00000261266.5_Missense_Mutation_p.K1593R	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1593	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGTGAATTCCTTCAGGTCCTC	0.363000													4	55					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31332622	31332622	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31332622G>A	ENST00000544665.3	+	15	1842	c.1771G>A	c.(1771-1773)Ggc>Agc	p.G591S	ITGAM_ENST00000287497.8_Missense_Mutation_p.G590S	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	590					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						ACTGAGTGGGGGCCAGGACCT	0.562000													35	140					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57529548	57529548	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:57529548G>T	ENST00000420713.1	+	4	1493	c.1381G>T	c.(1381-1383)Gag>Tag	p.E461*		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TCATACTGGAGAGAAACCCTA	0.358000													7	10					2.0095e-06	2.01378e-06	1	1	0
GRB7	2886	broad.mit.edu	37	17	37898880	37898880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37898880G>A	ENST00000309156.4	+	3	474	c.217G>A	c.(217-219)Gag>Aag	p.E73K	GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000394204.1_Missense_Mutation_p.E73K|GRB7_ENST00000394209.2_Missense_Mutation_p.E73K|GRB7_ENST00000309185.3_Missense_Mutation_p.E73K|GRB7_ENST00000445327.2_Missense_Mutation_p.E96K|GRB7_ENST00000394211.3_Missense_Mutation_p.E73K	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	73					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCCCTTCCCTGAGCTCTGCAG	0.637000													33	96					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94772575	94772575	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94772575G>A	ENST00000283357.5	+	7	904	c.858G>A	c.(856-858)ggG>ggA	p.G286G		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	286										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		TGGTCCAGGGGGATTATCGCC	0.398000													18	50					0	0	1	0	0
TTLL9	164395	broad.mit.edu	37	20	30510853	30510853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30510853G>A	ENST00000375938.4	+	8	914	c.661G>A	c.(661-663)Gga>Aga	p.G221R	TTLL9_ENST00000310998.4_Missense_Mutation_p.G171R|TTLL9_ENST00000535842.1_Missense_Mutation_p.G221R|TTLL9_ENST00000375934.4_Missense_Mutation_p.G203R|TTLL9_ENST00000375922.4_Missense_Mutation_p.G148R|TTLL9_ENST00000375921.2_Missense_Mutation_p.G148R			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	221	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TTACCTGATAGGAGGTGAGAT	0.483000													27	73					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881391	26881391	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:26881391C>A	ENST00000231021.4	-	12	2396	c.2224G>T	c.(2224-2226)Ggg>Tgg	p.G742W		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	742					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GAATCATTCCCTTCATAGGCA	0.418000													32	122					6.00712e-18	6.04278e-18	1	1	0
MUC16	94025	broad.mit.edu	37	19	9067623	9067623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9067623G>A	ENST00000397910.4	-	3	20026	c.19823C>T	c.(19822-19824)tCg>tTg	p.S6608L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6610	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGACAGACGAATAAGATTC	0.443000													18	214					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304663	10304663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10304663G>A	ENST00000403437.2	-	24	3131	c.3037C>T	c.(3037-3039)Ctg>Ttg	p.L1013L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1013					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCTGCCTGCAGGTCATCCAGG	0.458000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				86	119					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404233	20404233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20404233G>A	ENST00000285600.4	+	1	467	c.408G>A	c.(406-408)atG>atA	p.M136I		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GTACAATTATGAACCGGAGGC	0.443000													33	82					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56525338	56525338	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56525338C>T	ENST00000394048.5	+	6	1056	c.792C>T	c.(790-792)ttC>ttT	p.F264F	ESYT1_ENST00000541590.1_Silent_p.F264F|ESYT1_ENST00000267113.4_Silent_p.F264F	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	264						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						CAATGTTCTTCATCCGACGCC	0.537000													49	140					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1562297	1562297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1562297C>T	ENST00000357210.4	+	10	1548	c.1332C>T	c.(1330-1332)acC>acT	p.T444T	MIB2_ENST00000378710.3_Silent_p.T408T|MIB2_ENST00000505820.2_Silent_p.T501T|MIB2_ENST00000360522.4_Silent_p.T409T|MIB2_ENST00000504599.1_Silent_p.T400T|MIB2_ENST00000355826.5_Silent_p.T487T|MIB2_ENST00000378712.1_Silent_p.T321T|MIB2_ENST00000520777.1_Silent_p.T497T|MIB2_ENST00000518681.1_Silent_p.T436T|MIB2_ENST00000378708.1_Silent_p.T350T	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	444					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGCGGTGGACCTTCAGCCCCT	0.687000													9	14					0	0	1	0	0
KLRC2	3822	broad.mit.edu	37	12	10584713	10584713	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10584713G>A	ENST00000381902.2	-	5	582	c.576C>T	c.(574-576)ttC>ttT	p.F192F	NKG2-E_ENST00000539033.1_Intron|KLRC2_ENST00000536833.2_Silent_p.F133F|KLRC2_ENST00000381901.1_Silent_p.F192F	NM_002260.3	NP_002251.2	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C, member 2	192	C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity			kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11						ACTTATGTTTGAAAGCCAAAC	0.313000													7	36					0	0	1	0	0
OR56B1	387748	broad.mit.edu	37	11	5757959	5757959	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5757959C>T	ENST00000317121.3	+	1	279	c.213C>T	c.(211-213)ttC>ttT	p.F71F	TRIM5_ENST00000380027.1_Intron	NM_001005180.2	NP_001005180.1	Q8NGI3	O56B1_HUMAN	olfactory receptor, family 56, subfamily B, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.086)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.184)		TGTATATTTTCCTTGGCATCC	0.493000													16	50					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116045904	116045904	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116045904G>A	ENST00000603594.1	+	11	1525	c.1204G>A	c.(1204-1206)Gat>Aat	p.D402N	VWA2_ENST00000392982.3_Missense_Mutation_p.D402N	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	402	VWFA 2.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GGAGTACCAGGATGTGCCTGA	0.682000													19	69					0	0	1	0	0
RP11-159L20.2	0	broad.mit.edu	37	14	31290653	31290653	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:31290653C>T	ENST00000554665.1	-	0	208																											GGGCAAGTTCCTGAAACCTCG	0.473000													12	38					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247835510	247835510	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247835510C>T	ENST00000359688.2	-	1	855	c.834G>A	c.(832-834)gtG>gtA	p.V278V	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V278V(2)		endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATGTGGGAGTCACAAGAGTAT	0.438000													11	122					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62195402	62195402	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62195402G>A	ENST00000467148.1	-	8	4842	c.4773C>T	c.(4771-4773)ccC>ccT	p.P1591P	HELZ2_ENST00000427522.2_Silent_p.P1022P	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GCGTGTCGGGGGGACTGCCCC	0.687000													4	10					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060477	54060477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54060477G>A	ENST00000312233.2	-	3	665	c.99C>T	c.(97-99)acC>acT	p.T33T		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	33					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						AAGGCGCAGGGGTGGCGAGGC	0.721000													3	21					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156814576	156814576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156814576G>A	ENST00000368195.3	-	13	2893	c.2497C>T	c.(2497-2499)Ctt>Ttt	p.L833F	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	833	Fibronectin type-III 3.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CAGCGCAGAAGGACACTGTTC	0.617000													22	55					0	0	1	0	0
PPA2	27068	broad.mit.edu	37	4	106367581	106367581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:106367581G>A	ENST00000341695.5	-	5	430	c.400C>T	c.(400-402)Cct>Tct	p.P134S	PPA2_ENST00000432483.2_Intron|PPA2_ENST00000348706.5_Missense_Mutation_p.P134S|PPA2_ENST00000354147.3_Intron|PPA2_ENST00000509426.1_5'UTR|PPA2_ENST00000380004.2_Missense_Mutation_p.P116S|PPA2_ENST00000310267.7_Missense_Mutation_p.P55S|PPA2_ENST00000357415.4_Missense_Mutation_p.P149S	NM_176869.2	NP_789845.1	Q9H2U2	IPYR2_HUMAN	pyrophosphatase (inorganic) 2	134					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	11		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)		CCCTTGTAAGGGAAGATATTC	0.373000													12	144					0	0	1	0	0
EIF2D	1939	broad.mit.edu	37	1	206778857	206778857	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:206778857G>A	ENST00000271764.2	-	5	634	c.426C>T	c.(424-426)gcC>gcT	p.A142A	EIF2D_ENST00000367114.3_Silent_p.A142A	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	142	PUA.				intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						TGGCTACAGGGGCTCTAAGAA	0.512000													9	25					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105459626	105459626	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:105459626C>T	ENST00000351513.2	-	3	661	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	177					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGAAGGCTTCGTACAGCTCC	0.428000													16	65					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39156146	39156146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39156146C>T	ENST00000301819.6	+	6	806	c.629C>T	c.(628-630)tCa>tTa	p.S210L	TTC21A_ENST00000431162.2_Missense_Mutation_p.S210L|TTC21A_ENST00000440121.1_Missense_Mutation_p.S169L	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	210							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		ACTGTGACTTCAGGGAGCTTC	0.552000													47	105					0	0	1	0	0
RALYL	138046	broad.mit.edu	37	8	85799849	85799849	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:85799849G>A	ENST00000521268.1	+	8	1801	c.696G>A	c.(694-696)aaG>aaA	p.K232K	RALYL_ENST00000521376.1_Intron|RALYL_ENST00000521695.1_Silent_p.K232K|RALYL_ENST00000522455.1_Silent_p.K232K|RALYL_ENST00000518566.1_Silent_p.K221K|RALYL_ENST00000517638.1_Silent_p.K245K|RALYL_ENST00000523850.1_Silent_p.K159K	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	232							identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						AAGCTCAGAAGAAGCAATTGG	0.483000													5	67					0	0	1	0	0
LLGL2	3993	broad.mit.edu	37	17	73567144	73567144	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73567144C>T	ENST00000392550.3	+	17	2256	c.2139C>T	c.(2137-2139)gtC>gtT	p.V713V	LLGL2_ENST00000577200.1_Silent_p.V713V|LLGL2_ENST00000167462.5_Silent_p.V713V	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	713					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CAGGCTTCGTCCGGACCCTGT	0.652000													51	119					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144942348	144942348	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144942348C>T	ENST00000525985.1	-	2	5145	c.5074G>A	c.(5074-5076)Gac>Aac	p.D1692N				P58107	EPIPL_HUMAN	epiplakin 1	1692						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCACGGGGTCGATGATGCCG	0.677000													32	68					0	0	1	0	0
TLE6	79816	broad.mit.edu	37	19	2989206	2989206	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2989206C>T	ENST00000246112.4	+	12	1089	c.888C>T	c.(886-888)agC>agT	p.S296S	TLE6_ENST00000452088.1_Silent_p.S173S|TLE6_ENST00000478073.2_3'UTR	NM_001143986.1	NP_001137458.1	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)	173					regulation of transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCATCAGCAGCTTCACGCGGC	0.617000													13	34					0	0	1	0	0
S1PR3	1903	broad.mit.edu	37	9	91616901	91616901	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:91616901C>T	ENST00000375846.3	+	1	5481	c.786C>T	c.(784-786)ctC>ctT	p.L262L	S1PR3_ENST00000358157.2_Silent_p.L262L			Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	262					anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(1)	34						TCTTCATCCTCTTCCTCATTG	0.597000													22	29					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79429947	79429947	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79429947C>T	ENST00000264895.6	+	63	10007	c.9567C>T	c.(9565-9567)tcC>tcT	p.S3189S		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3184					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCAAGAAATCCCCCTCCCCAG	0.547000													9	21					0	0	1	0	0
MAP9	79884	broad.mit.edu	37	4	156289882	156289882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156289882C>T	ENST00000311277.4	-	5	827	c.564G>A	c.(562-564)atG>atA	p.M188I	AC097467.2_ENST00000596165.1_RNA|AC097467.2_ENST00000597831.1_RNA|MAP9_ENST00000379248.2_Missense_Mutation_p.M115I|MAP9_ENST00000515654.1_Missense_Mutation_p.M188I	NM_001039580.1	NP_001034669.1	Q49MG5	MAP9_HUMAN	microtubule-associated protein 9	188					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		CCTTCTCCTCCATGTGACTTT	0.413000													12	101					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220167069	220167069	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220167069C>T	ENST00000295718.2	-	6	1024	c.784G>A	c.(784-786)Ggg>Agg	p.G262R	PTPRN_ENST00000423636.2_Missense_Mutation_p.G172R|PTPRN_ENST00000409251.3_Missense_Mutation_p.G262R|AC114803.3_ENST00000417355.1_RNA	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	262					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GGAAGGTCCCCGTAGGAGTGG	0.632000													9	18					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54554948	54554948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54554948C>T	ENST00000566473.2	+	15	1882	c.1882C>T	c.(1882-1884)Ctt>Ttt	p.L628F	ANKFN1_ENST00000318698.2_Missense_Mutation_p.L628F			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	628										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						AATCAAAGTTCTTGTTACCCA	0.393000													49	116					0	0	1	0	0
MAGEB1	4112	broad.mit.edu	37	X	30268851	30268851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:30268851G>A	ENST00000378981.3	+	4	562	c.241G>A	c.(241-243)Gaa>Aaa	p.E81K	MAGEB1_ENST00000397550.1_Missense_Mutation_p.E81K|MAGEB1_ENST00000397548.2_Missense_Mutation_p.E81K	NM_002363.4	NP_002354.2	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	81										NS(2)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	32						CGAATCTGACGAAGGTGCCAA	0.557000													3	5					0	0	1	0	0
XKRX	402415	broad.mit.edu	37	X	100177947	100177947	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:100177947C>T	ENST00000328526.5	-	2	1043	c.478G>A	c.(478-480)Gag>Aag	p.E160K	XKRX_ENST00000468904.1_Intron|XKRX_ENST00000372956.2_Missense_Mutation_p.E147K	NM_212559.2	NP_997724.2	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related, X-linked	147						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(3)	22						ATCAGCACCTCCTCGCCATCT	0.537000													71	60					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122759247	122759247	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122759247G>A	ENST00000194130.2	-	13	1439	c.1400C>T	c.(1399-1401)tCa>tTa	p.S467L	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	467						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TGCTGGTAATGAACCCAGAGG	0.343000													16	58					0	0	1	0	0
CHRNG	1146	broad.mit.edu	37	2	233410375	233410375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233410375G>A	ENST00000389494.3	+	12	1524	c.1503G>A	c.(1501-1503)ccG>ccA	p.P501P	CHRNG_ENST00000389492.3_Silent_p.P449P	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	501					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		ACCGGGTGCCGGCCCTGCCAT	0.632000													8	75					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94156635	94156635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94156635C>T	ENST00000553484.1	+	47	7595	c.7441C>T	c.(7441-7443)Cca>Tca	p.P2481S	UNC79_ENST00000555664.1_Missense_Mutation_p.P2420S|UNC79_ENST00000393151.2_Missense_Mutation_p.P2459S|UNC79_ENST00000256339.4_Missense_Mutation_p.P2282S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2459						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GATTGGATTTCCAGAGCAATC	0.453000													20	101					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227400880	227400880	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:227400880G>A	ENST00000366769.3	-	3	1602	c.311C>T	c.(310-312)gCc>gTc	p.A104V	CDC42BPA_ENST00000334218.5_Missense_Mutation_p.A104V|CDC42BPA_ENST00000366767.3_Missense_Mutation_p.A104V|CDC42BPA_ENST00000366765.3_Missense_Mutation_p.A104V|CDC42BPA_ENST00000366766.2_Missense_Mutation_p.A104V|CDC42BPA_ENST00000366764.2_Missense_Mutation_p.A104V|CDC42BPA_ENST00000535525.1_Missense_Mutation_p.A104V	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	104	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				TATTTTCATGGCAAACACTTT	0.249000													15	108					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30572209	30572209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30572209C>T	ENST00000376511.2	-	13	1734	c.1182G>A	c.(1180-1182)agG>agA	p.R394R		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	394	Essential for PPP1CA inhibition (By similarity).|Necessary for interaction with PPP1CA (By similarity).|Necessary for interaction with PPP1CC.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						TTTTCCTCTTCCTGCCTTTCC	0.483000													57	132					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148932900	148932900	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:148932900G>A	ENST00000539543.1	+	0	156					NR_027355.1																						TCAGTCTGCGGCCAAGACTCC	0.612000													8	146					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170003441	170003441	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170003441C>T	ENST00000263816.3	-	69	12904	c.12619G>A	c.(12619-12621)Gaa>Aaa	p.E4207K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4207					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATTTTAGGTTCCTTTCCCCAG	0.473000													12	33					0	0	1	0	0
PTPRE	5791	broad.mit.edu	37	10	129847804	129847804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129847804G>A	ENST00000471218.1	+	5	348	c.289G>A	c.(289-291)Ggt>Agt	p.G97S	PTPRE_ENST00000430713.2_Silent_p.R98R|PTPRE_ENST00000306042.5_Silent_p.R40R|PTPRE_ENST00000419012.2_Silent_p.R98R|PTPRE_ENST00000254667.3_Silent_p.R98R			P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	0					negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				AGCAGCAAAGGGTGATGCTGC	0.542000													24	70					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5655066	5655066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5655066G>A	ENST00000354852.5	+	9	1691	c.1518G>A	c.(1516-1518)aaG>aaA	p.K506K	HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000514226.1_Silent_p.K152K|TRIM34_ENST00000429814.2_Silent_p.K152K|TRIM6-TRIM34_ENST00000457787.2_Silent_p.K152K	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		506						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		AGAGGCTGAAGAAGGAAGAGG	0.453000													9	53					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148614388	148614388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:148614388G>A	ENST00000296046.3	+	11	1200	c.1148G>A	c.(1147-1149)gGc>gAc	p.G383D	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	383					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding	p.G383V(1)		NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CGAGATAAAGGCAAATTTGGT	0.433000													55	66					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768823	57768823	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57768823C>T	ENST00000371030.2	+	1	2749	c.2749C>T	c.(2749-2751)Ccc>Tcc	p.P917S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	917						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CGCAGAGCACCCCTCGCTGGC	0.632000													22	46					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47628897	47628897	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:47628897C>T	ENST00000546455.1	+	4	782	c.51C>T	c.(49-51)ttC>ttT	p.F17F	PCED1B_ENST00000432328.1_Silent_p.F17F					PC-esterase domain containing 1B									p.F17F(2)									ACAATAAGTTCGTGGTCATCC	0.592000													31	23					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126051160	126051160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:126051160G>A	ENST00000318410.7	-	25	3345	c.2996C>T	c.(2995-2997)tCa>tTa	p.S999L	KIAA0196_ENST00000517845.1_Missense_Mutation_p.S851L	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	999					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GTAAGGAAGTGAAGGGTCCTG	0.403000													24	133					0	0	1	0	0
ZNF569	148266	broad.mit.edu	37	19	37904945	37904945	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:37904945C>T	ENST00000316950.6	-	6	1172	c.615G>A	c.(613-615)ctG>ctA	p.L205L	ZNF569_ENST00000392150.2_Silent_p.L46L|ZNF569_ENST00000392149.2_Silent_p.L205L	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGAATTCTCAGATGTCTGA	0.363000													27	72					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8118269	8118269	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8118269G>A	ENST00000305253.4	+	7	1009	c.768G>A	c.(766-768)gaG>gaA	p.E256E	TUB_ENST00000534099.1_Silent_p.E207E|TUB_ENST00000299506.2_Silent_p.E201E	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	201					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AGGATGAGGAGGATGAGGAGG	0.542000													18	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615810	179615810	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179615810G>A	ENST00000360870.5	-	46	11539	c.11317C>T	c.(11317-11319)Cca>Tca	p.P3773S	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9610							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGGCATGTGGATTTTGCACA	0.348000													12	184					0	0	1	0	0
NXF2B	728343	broad.mit.edu	37	X	101620169	101620169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:101620169G>A	ENST00000457521.2	-	27	3148	c.1277C>T	c.(1276-1278)cCc>cTc	p.P426L	NXF2B_ENST00000372752.1_Missense_Mutation_p.P338L|NXF2B_ENST00000372749.1_Missense_Mutation_p.P426L|NXF2B_ENST00000412230.2_Missense_Mutation_p.P426L|NXF2B_ENST00000489531.1_5'UTR|NXF2B_ENST00000372750.1_Missense_Mutation_p.P426L					nuclear RNA export factor 2B											breast(1)|kidney(1)|lung(4)|ovary(1)	7						GGGGTCGAAGGGAATAGCCAA	0.572000													20	53					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226491723	226491723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:226491723C>T	ENST00000272907.6	+	5	2122	c.1709C>T	c.(1708-1710)tCc>tTc	p.S570F	NYAP2_ENST00000409269.2_Silent_p.F104F	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	570																	GGGGCGTCTTCCTCCAGAGAG	0.527000													5	12					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122631747	122631747	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122631747G>A	ENST00000195173.4	-	18	2968	c.2665C>T	c.(2665-2667)Ctg>Ttg	p.L889L	SEMA5B_ENST00000357599.3_Silent_p.L890L|SEMA5B_ENST00000451055.2_Silent_p.L944L			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	890	TSP type-1 3.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		ACGCAGGGCAGGCCCCCGTTG	0.687000													42	76					0	0	1	0	0
C1QTNF3	114899	broad.mit.edu	37	5	34043182	34043182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:34043182G>A	ENST00000382065.3	-	1	755	c.49C>T	c.(49-51)Ctc>Ttc	p.L17F	C1QTNF3_ENST00000231338.7_Missense_Mutation_p.L17F	NM_181435.5	NP_852100.3	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	0						collagen				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|prostate(3)|stomach(1)|urinary_tract(1)	17	all_lung(31;0.0207)					CAAAAAGGGAGGAAAAACAAA	0.493000													54	160					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39963869	39963869	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39963869C>T	ENST00000599117.1	+	25	2652	c.2285C>T	c.(2284-2286)aCc>aTc	p.T762I	SUPT5H_ENST00000359191.6_Missense_Mutation_p.T758I|SUPT5H_ENST00000402194.2_Missense_Mutation_p.T758I|SUPT5H_ENST00000598725.1_Missense_Mutation_p.T762I|SUPT5H_ENST00000432763.2_Missense_Mutation_p.T762I			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	762	9 X 7 AA approximate tandem repeats of G- S-[QR]-T-P-X-[YQ], motif CTR1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGCGGCATGACCTCGACCTAT	0.652000													20	62					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087396	92087396	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92087396G>A	ENST00000298047.6	+	1	2135	c.2118G>A	c.(2116-2118)ctG>ctA	p.L706L	FAT3_ENST00000541502.1_Silent_p.L706L|FAT3_ENST00000409404.2_Silent_p.L706L|FAT3_ENST00000525166.1_Silent_p.L556L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	706					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGGGAAACTGAATCTGGAAG	0.403000										TCGA Ovarian(4;0.039)			34	114					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14746012	14746012	+	Silent	SNP	C	C	T	rs147231935		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14746012C>T	ENST00000284268.6	-	7	1212	c.882G>A	c.(880-882)acG>acA	p.T294T	ANKH_ENST00000503939.1_5'UTR|ANKH_ENST00000535119.1_Silent_p.T96T	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	294					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CACGGATTTCCGTCAACCAGC	0.522000													15	57					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52944946	52944946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52944946C>T	ENST00000295213.4	+	8	1440	c.1066C>T	c.(1066-1068)Cat>Tat	p.H356Y	SPATA18_ENST00000419395.2_Missense_Mutation_p.H324Y	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	356					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CTTCAAGATCCATGTGAGAAA	0.383000													27	120					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587530	179587530	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179587530T>C	ENST00000589042.1	-	76	22320	c.22096A>G	c.(22096-22098)Act>Gct	p.T7366A	TTN_ENST00000342992.6_Missense_Mutation_p.T6122A|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.T7049A	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7049	Ig-like 55.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTCAGGAGTTGGCCGTAAT	0.418000													10	30					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477672	88477672	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:88477672G>A	ENST00000267549.3	+	2	1039	c.481G>A	c.(481-483)Gat>Aat	p.D161N	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	161					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity	p.D161N(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TGAATATTGCGATGCCGAAAA	0.393000													42	146					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49569672	49569672	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49569672C>T	ENST00000545947.1	+	6	2450	c.1728C>T	c.(1726-1728)ttC>ttT	p.F576F	DAG1_ENST00000538711.1_Silent_p.F576F|DAG1_ENST00000539901.1_Silent_p.F576F|DAG1_ENST00000308775.2_Silent_p.F576F|DAG1_ENST00000515359.2_Silent_p.F576F|DAG1_ENST00000541308.1_Silent_p.F576F	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	576	Peptidase S72.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		ACGAGTATTTCATGCATGCCA	0.597000													28	36					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460299	107460299	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107460299G>A	ENST00000409382.3	-	2	745	c.135C>T	c.(133-135)ttC>ttT	p.F45F	ST6GAL2_ENST00000361686.4_Silent_p.F45F|ST6GAL2_ENST00000409087.3_Silent_p.F45F	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	45					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						TGGTCTCCAGGAAGGAGAGGG	0.632000													4	47					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142605697	142605697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142605697C>T	ENST00000265310.1	-	15	2521	c.2173G>A	c.(2173-2175)Gag>Aag	p.E725K		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	725	Involved in Ca(2+)-dependent inactivation (By similarity).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					TGGTAGACCTCCTCTCCATCC	0.557000													27	69					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125140818	125140818	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125140818C>T	ENST00000362012.2	+	4	323	c.318C>T	c.(316-318)ttC>ttT	p.F106F	PTGS1_ENST00000373698.5_5'UTR|PTGS1_ENST00000540753.1_Silent_p.F81F|PTGS1_ENST00000223423.4_Silent_p.F106F	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	106					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	ATGCCACCTTCATCCGAGAGA	0.602000													15	54					0	0	1	0	0
COLEC12	81035	broad.mit.edu	37	18	357510	357510	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:357510C>T	ENST00000400256.3	-	3	278	c.71G>A	c.(70-72)gGa>gAa	p.G24E		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	24					carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				ACATTGTGTTCCTTCCTGAAT	0.303000													17	59					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150840933	150840933	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150840933G>A	ENST00000370357.4	+	14	1961	c.1716G>A	c.(1714-1716)ctG>ctA	p.L572L		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	572						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					agcagccactgaagcaTAATG	0.522000													7	27					0	0	1	0	0
EHF	26298	broad.mit.edu	37	11	34668007	34668007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:34668007G>A	ENST00000257831.3	+	3	240	c.119G>A	c.(118-120)gGc>gAc	p.G40D	EHF_ENST00000450654.2_Missense_Mutation_p.G40D|EHF_ENST00000527935.1_Missense_Mutation_p.G40D|EHF_ENST00000530286.1_Missense_Mutation_p.G40D|EHF_ENST00000531794.1_Missense_Mutation_p.G62D|EHF_ENST00000531728.1_Missense_Mutation_p.G40D|EHF_ENST00000527001.1_3'UTR|EHF_ENST00000533754.1_Missense_Mutation_p.G40D	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	40	PNT.			G -> S (in Ref. 2; AAD30990/AAD30991).	cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			TTTTTTGGAGGCCAGTGGCAT	0.527000													55	65					0	0	1	0	0
CLDN14	23562	broad.mit.edu	37	21	37833960	37833960	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37833960G>A	ENST00000399137.1	-	3	900	c.34C>T	c.(34-36)Ctg>Ttg	p.L12L	CLDN14_ENST00000399139.1_Silent_p.L12L|CLDN14_ENST00000399135.1_Silent_p.L12L|AP000695.6_ENST00000429588.1_RNA|CLDN14_ENST00000342108.2_Silent_p.L12L|CLDN14_ENST00000399136.1_Silent_p.L12L|AP000695.4_ENST00000428667.1_RNA	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	12					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						AAGCTGAGCAGGAAGCCCAGA	0.697000													3	12					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34888154	34888154	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34888154C>A	ENST00000360581.1	+	8	1032	c.904C>A	c.(904-906)Ctt>Att	p.L302I	NPSR1_ENST00000381542.1_Missense_Mutation_p.L236I|NPSR1_ENST00000381539.3_Missense_Mutation_p.L302I|NPSR1_ENST00000359791.1_Missense_Mutation_p.L302I|NPSR1_ENST00000531252.1_Missense_Mutation_p.L291I	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	302						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	TTTCAACCTCCTTCCAGACAC	0.493000													23	283					2.21704e-12	2.22766e-12	1	1	0
PPP6R3	55291	broad.mit.edu	37	11	68343463	68343463	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68343463C>T	ENST00000393799.2	+	14	1764	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	PPP6R3_ENST00000524904.1_Silent_p.F499F|PPP6R3_ENST00000265636.5_Silent_p.F448F|PPP6R3_ENST00000393801.3_Silent_p.F499F|PPP6R3_ENST00000393800.2_Silent_p.F499F|PPP6R3_ENST00000534534.1_Silent_p.F267F|PPP6R3_ENST00000529710.1_Silent_p.F448F|PPP6R3_ENST00000265637.4_Silent_p.F499F|PPP6R3_ENST00000524845.1_Silent_p.F499F|PPP6R3_ENST00000527403.2_Silent_p.F499F			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	499					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						GGGAGACGTTCTGCACAAGCT	0.428000													46	104					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717018	142717018	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142717018A>G	ENST00000381779.4	-	2	2132	c.1907T>C	c.(1906-1908)tTt>tCt	p.F636S	SLITRK4_ENST00000356928.1_Missense_Mutation_p.F636S|SLITRK4_ENST00000338017.4_Missense_Mutation_p.F636S	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	636						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAAGGCAAAAAGCAACAAA	0.493000													40	34					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190423945	190423945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:190423945G>A	ENST00000367462.3	-	2	307	c.76C>T	c.(76-78)Cat>Tat	p.H26Y	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		26						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					ACCCAGCAATGAAGACTCAGT	0.522000													16	45					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73682332	73682332	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:73682332C>T	ENST00000264448.6	+	9	7692	c.7581C>T	c.(7579-7581)tcC>tcT	p.S2527S	ALMS1_ENST00000409009.1_Silent_p.S2485S|ALMS1_ENST00000377715.1_Silent_p.S2527S	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2527					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GTGGATACTCCATTTCAGAAT	0.358000													16	131					0	0	1	0	0
DLX4	1748	broad.mit.edu	37	17	48050471	48050471	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48050471C>T	ENST00000240306.3	+	2	613	c.318C>T	c.(316-318)tcC>tcT	p.S106S	DLX4_ENST00000411890.2_Silent_p.S34S|DLX4_ENST00000503410.1_3'UTR	NM_138281.2	NP_612138.1	Q92988	DLX4_HUMAN	distal-less homeobox 4	106					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(3)	10						CGGAACCCTCCGAGCGGCGCC	0.662000													25	51					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94114841	94114841	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94114841C>T	ENST00000515393.1	-	19	2583	c.2584G>A	c.(2584-2586)Gaa>Aaa	p.E862K	MCTP1_ENST00000312216.8_Missense_Mutation_p.E641K|MCTP1_ENST00000429576.2_Missense_Mutation_p.E555K|MCTP1_ENST00000514040.1_5'UTR|MCTP1_ENST00000505078.1_Missense_Mutation_p.E378K	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	862					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TCTTCTTCTTCCTCGTCCTCT	0.418000													24	105					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7310207	7310207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7310207C>T	ENST00000537408.1	+	16	3224	c.2686C>T	c.(2686-2688)Cca>Tca	p.P896S	CLSTN3_ENST00000331148.5_3'UTR|CLSTN3_ENST00000266546.6_Missense_Mutation_p.P884S			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	884					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						CGGCGGGCCTCCAGGGGCCTC	0.642000													9	17					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38942416	38942416	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38942416C>T	ENST00000355481.4	+	12	1266	c.1135C>T	c.(1135-1137)Cag>Tag	p.Q379*	RYR1_ENST00000360985.3_Nonsense_Mutation_p.Q379*|RYR1_ENST00000359596.3_Nonsense_Mutation_p.Q379*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	379	MIR 5.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CATGCTGCACCAGGAGGGCCA	0.632000													18	65					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827076	96827076	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96827076G>A	ENST00000371270.3	-	3	464	c.370C>T	c.(370-372)Cgg>Tgg	p.R124W	CYP2C8_ENST00000539050.1_Missense_Mutation_p.R38W|CYP2C8_ENST00000535898.1_Missense_Mutation_p.R22W	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	124					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GAGAAACGCCGGATCTCCTTC	0.488000													37	105					0	0	1	0	0
TRBV6-8	28599	broad.mit.edu	37	7	142124345	142124345	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142124345C>T	ENST00000390376.2	-	0	132																											TGGTTCATATCCTGGGCACAC	0.493000													47	108					0	0	1	0	0
METTL4	64863	broad.mit.edu	37	18	2566965	2566965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:2566965C>T	ENST00000319888.6	-	2	1049	c.251G>A	c.(250-252)cGa>cAa	p.R84Q	METTL4_ENST00000574538.1_Missense_Mutation_p.R84Q			Q8N3J2	METL4_HUMAN	methyltransferase like 4	84					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						AACAAATTTTCGTGTGAACAT	0.393000													31	96					0	0	1	0	0
ZYG11B	79699	broad.mit.edu	37	1	53236939	53236939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53236939C>T	ENST00000294353.6	+	3	589	c.444C>T	c.(442-444)ctC>ctT	p.L148L	ZYG11B_ENST00000545132.1_Silent_p.L148L|ZYG11B_ENST00000443756.2_Silent_p.L148L	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	148							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						CATTAACTCTCTCCCTCGAGG	0.473000													10	78					0	0	1	0	0
GFPT1	2673	broad.mit.edu	37	2	69556865	69556865	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69556865G>A	ENST00000357308.4	-	16	1726	c.1548C>T	c.(1546-1548)tcC>tcT	p.S516S	GFPT1_ENST00000361060.4_Silent_p.S498S	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	516	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						TTTCTTGCATGGAGATCCGAT	0.418000													6	90					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461789	11461789	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11461789C>T	ENST00000279575.1	-	3	161	c.128G>A	c.(127-129)gGa>gAa	p.G43E	PRB4_ENST00000535904.1_Missense_Mutation_p.G43E|PRB4_ENST00000445719.2_Missense_Mutation_p.G43E	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	43	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						CTGGTTTCCTCCTTGTGGGCG	0.562000										HNSCC(22;0.051)			98	248					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75927692	75927692	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75927692C>T	ENST00000274364.6	+	15	1918	c.1621C>T	c.(1621-1623)Ctg>Ttg	p.L541L	IQGAP2_ENST00000396234.3_Silent_p.L94L|IQGAP2_ENST00000502745.1_Silent_p.L94L|IQGAP2_ENST00000379730.3_Silent_p.L100L	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	541					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGGGGTTACTCTGGTGGTTGA	0.338000													10	49					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39023355	39023355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39023355G>A	ENST00000355481.4	+	77	11354	c.11223G>A	c.(11221-11223)gaG>gaA	p.E3741E	RYR1_ENST00000360985.3_Silent_p.E3746E|RYR1_ENST00000359596.3_Silent_p.E3746E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3746					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AAGCTGAAGAGGAGGTTGAGG	0.597000													19	44					0	0	1	0	0
PSME2	5721	broad.mit.edu	37	14	24613611	24613611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24613611G>A	ENST00000216802.5	-	7	1066	c.427C>T	c.(427-429)Cag>Tag	p.Q143*	PSME2_ENST00000560410.1_Nonsense_Mutation_p.Q132*|PSME2_ENST00000471700.2_5'UTR	NM_002818.2	NP_002809.2	Q9UL46	PSME2_HUMAN	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	143					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex				endometrium(1)|lung(3)|prostate(2)	6				GBM - Glioblastoma multiforme(265;0.00839)		TTTCTTACCTGGATTGCTACC	0.438000													10	108					0	0	1	0	0
MOCOS	55034	broad.mit.edu	37	18	33848614	33848614	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:33848614C>T	ENST00000261326.5	+	15	2654	c.2633C>T	c.(2632-2634)cCt>cTt	p.P878L		NM_017947.2	NP_060417.2	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	878					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding	p.P878H(1)		breast(2)|endometrium(5)|kidney(1)|large_intestine(10)|liver(1)|lung(15)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43					Pyridoxal Phosphate(DB00114)	CATGATTTACCTGCATCTGAG	0.388000													5	89					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25043589	25043589	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:25043589C>T	ENST00000216336.2	-	4	492	c.456G>A	c.(454-456)atG>atA	p.M152I		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	152	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		TTCCCCTCCTCATGCTGACCC	0.617000													40	106					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135447863	135447863	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135447863G>A	ENST00000343036.2	+	7	977	c.929G>A	c.(928-930)gGg>gAg	p.G310E	C9orf171_ENST00000393216.2_Missense_Mutation_p.G274E	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	310										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						GTGCGCCAGGGGACCCTGCGG	0.597000													6	36					0	0	1	0	0
TMEM120B	144404	broad.mit.edu	37	12	122209422	122209422	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122209422C>T	ENST00000449592.2	+	8	747	c.646C>T	c.(646-648)Cgc>Tgc	p.R216C	TMEM120B_ENST00000540377.1_Intron	NM_001080825.2	NP_001074294.2	A0PK00	T120B_HUMAN	transmembrane protein 120B	216						integral to membrane		p.R216C(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(6)	11	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		TCAGAAGTTTCGCAACCAGTT	0.488000													29	88					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202735	56202735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56202735C>T	ENST00000361673.3	-	5	4897	c.4684G>A	c.(4684-4686)Ggc>Agc	p.G1562S	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1562							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TGAATTTGGCCTGTGGAGTTG	0.448000													27	96					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241835039	241835039	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241835039C>T	ENST00000388934.4	-	1	534	c.376G>A	c.(376-378)Gag>Aag	p.E126K		NM_001085437.1	NP_001078906.1	Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	126										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		AAGGTATCCTCGGTGGTCCAC	0.622000													5	35					0	0	1	0	0
CLPS	1208	broad.mit.edu	37	6	35765005	35765005	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35765005G>A	ENST00000259938.2	-	1	83	c.61C>T	c.(61-63)Ccc>Tcc	p.P21S		NM_001832.3	NP_001823.1	P04118	COL_HUMAN	colipase, pancreatic	21					lipid catabolic process|lipid digestion|retinoid metabolic process|steroid metabolic process	extracellular region				large_intestine(2)|lung(2)|prostate(1)	5						ATCCCCCGGGGGCCAGGAGCT	0.592000													24	135					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156924090	156924090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156924090G>A	ENST00000257527.4	-	14	1484	c.1406C>T	c.(1405-1407)gCt>gTt	p.A469V	ADAM19_ENST00000394020.1_Missense_Mutation_p.A471V|ADAM19_ENST00000430702.2_Missense_Mutation_p.A202V|ADAM19_ENST00000517905.1_Missense_Mutation_p.A469V	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	469	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTCCCAGGAGCCAACAGCTG	0.567000													6	28					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120702688	120702688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120702688C>T	ENST00000527524.2	+	7	926	c.639C>T	c.(637-639)gcC>gcT	p.A213A	GRIK4_ENST00000438375.2_Silent_p.A213A			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	213					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	ACAAGACCGCCACCATCATCA	0.642000													13	161					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53694273	53694273	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53694273G>A	ENST00000288139.3	+	5	855	c.737G>A	c.(736-738)cGa>cAa	p.R246Q	CACNA1D_ENST00000422281.2_Missense_Mutation_p.R246Q|CACNA1D_ENST00000350061.5_Missense_Mutation_p.R246Q	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	246					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CGAGTGTTGCGACCACTTCGA	0.478000													15	76					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60506800	60506800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60506800G>A	ENST00000371201.3	-	4	453	c.346C>T	c.(346-348)Ccc>Tcc	p.P116S	C1orf87_ENST00000450089.2_Intron	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	116							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GCTTGACTGGGAATCTTAACA	0.458000													14	23					0	0	1	0	0
EPYC	1833	broad.mit.edu	37	12	91371958	91371958	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91371958C>T	ENST00000261172.3	-	3	339	c.247G>A	c.(247-249)Gaa>Aaa	p.E83K		NM_004950.4	NP_004941.2	Q99645	EPYC_HUMAN	epiphycan	83	Poly-Glu.				female pregnancy	proteinaceous extracellular matrix	glycosaminoglycan binding	p.E83K(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|skin(2)	18						TCCTCCTCTTCCTCTTCCTGG	0.507000											OREG0022019	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	102					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1428303	1428303	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1428303G>A	ENST00000381524.3	+	13	1320	c.1134G>A	c.(1132-1134)tgG>tgA	p.W378*	CSF2RA_ENST00000381529.3_Nonsense_Mutation_p.W378*|CSF2RA_ENST00000417535.2_Nonsense_Mutation_p.W412*|CSF2RA_ENST00000501036.2_Nonsense_Mutation_p.W245*|CSF2RA_ENST00000381500.1_3'UTR|CSF2RA_ENST00000355432.3_Missense_Mutation_p.G319R|CSF2RA_ENST00000498153.1_3'UTR|CSF2RA_ENST00000361536.3_3'UTR|CSF2RA_ENST00000355805.2_3'UTR|CSF2RA_ENST00000432318.2_Nonsense_Mutation_p.W378*			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	378						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	AGATCATCTGGGAGGAATTCA	0.512000													39	76					0	0	1	0	0
OR2A7	401427	broad.mit.edu	37	7	143955944	143955944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143955944C>T	ENST00000493325.1	-	1	871	c.778G>A	c.(778-780)Gga>Aga	p.G260R	RP4-798C17.6_ENST00000478806.1_RNA|RP4-545C24.1_ENST00000460955.1_RNA|RP4-798C17.6_ENST00000463561.1_RNA|RP4-798C17.6_ENST00000487102.1_RNA|RP4-798C17.6_ENST00000489488.1_RNA|ARHGEF35_ENST00000543357.1_Intron|RP4-798C17.6_ENST00000476560.1_RNA|RP4-798C17.6_ENST00000461843.1_RNA	NM_001005328.1	NP_001005328.1	Q96R45	OR2A7_HUMAN	olfactory receptor, family 2, subfamily A, member 7	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	6	Melanoma(164;0.14)					TATCTGGGTCCAACATACATG	0.463000													20	176					0	0	1	0	0
WAPAL	23063	broad.mit.edu	37	10	88211809	88211809	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88211809G>A	ENST00000298767.5	-	15	3501	c.3029C>T	c.(3028-3030)tCt>tTt	p.S1010F	WAPAL_ENST00000263070.7_Intron|WAPAL_ENST00000372075.1_Intron	NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	1010	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						AGAATCAAAAGAGCACGATGT	0.428000													14	133					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57425826	57425826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57425826C>T	ENST00000371237.4	-	2	182	c.116G>A	c.(115-117)gGg>gAg	p.G39E	C8B_ENST00000535057.1_5'UTR|C8B_ENST00000494324.1_5'UTR|C8B_ENST00000543257.1_5'UTR	NM_000066.2	NP_000057.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	39					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGCATTTGACCCAAAGGAATG	0.428000													8	94					0	0	1	0	0
LOC653786	653786	broad.mit.edu	37	16	22588008	22588008	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:22588008C>T	ENST00000550753.1	+	0	2483					NR_003676.2																						TGGTGAGTGGCCTGAGCACAT	0.547000													8	51					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72351362	72351362	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72351362G>A	ENST00000389916.4	+	20	3046	c.2908G>A	c.(2908-2910)Ggt>Agt	p.G970S		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	970					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CCCCAACCCAGGTGGTGGTTC	0.667000													16	77					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17668880	17668880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17668880G>A	ENST00000375448.4	+	8	944	c.918G>A	c.(916-918)caG>caA	p.Q306Q	AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	306					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	AGCCCCCGCAGGAGGTGTACG	0.642000													15	43					0	0	1	0	0
CDCA7	83879	broad.mit.edu	37	2	174224139	174224139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:174224139G>A	ENST00000306721.3	+	3	407	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K	CDCA7_ENST00000410101.3_Missense_Mutation_p.E58K|CDCA7_ENST00000410019.3_Intron|CDCA7_ENST00000347703.3_Intron|CDCA7_ENST00000392567.2_Intron	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	0					regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.E102K(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			TGTCACTAACGAACTGGCCGG	0.423000													28	73					0	0	1	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947100	57947100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57947100C>T	ENST00000335397.3	+	3	500	c.184C>T	c.(184-186)Ctt>Ttt	p.L62F		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				AATGTATTTCCTTCTGAGTCA	0.468000													38	178					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44845619	44845619	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44845619C>T	ENST00000372262.3	-	4	1084	c.684G>A	c.(682-684)acG>acA	p.T228T	CDH22_ENST00000474438.1_5'UTR|CDH22_ENST00000537909.1_Silent_p.T228T	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	228	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CAGGCACAGCCGTCCGGATTA	0.652000													23	76					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70541868	70541868	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70541868C>T	ENST00000310961.5	+	24	4517	c.4099C>T	c.(4099-4101)Cag>Tag	p.Q1367*	LRRC7_ENST00000415775.2_Nonsense_Mutation_p.Q693*|LRRC7_ENST00000035383.5_Nonsense_Mutation_p.Q1409*			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1409						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCAGCAATTTCAGTCACCATT	0.522000													30	60					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103230142	103230142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103230142C>T	ENST00000424685.2	-	28	4205	c.4046G>A	c.(4045-4047)gGa>gAa	p.G1349E	RELN_ENST00000343529.5_Missense_Mutation_p.G1349E|RELN_ENST00000428762.1_Missense_Mutation_p.G1349E			P78509	RELN_HUMAN	reelin	1349					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.G1349E(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCTGGAGTTTCCTTCGCATCC	0.478000													39	109					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52554257	52554257	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52554257G>A	ENST00000321725.6	+	52	5526	c.5450G>A	c.(5449-5451)cGa>cAa	p.R1817Q		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1817	FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGCCCACTTCGAACCATGCAT	0.622000													11	154					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20249284	20249284	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20249284C>T	ENST00000315957.4	+	1	884	c.803C>T	c.(802-804)tCc>tTc	p.S268F		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S268F(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GACTCATTTTCCCTAGATAAA	0.418000													38	113					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96555182	96555182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:96555182G>A	ENST00000376747.3	-	21	2498	c.2428C>T	c.(2428-2430)Ctt>Ttt	p.L810F		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	810					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						AGTTGCCCAAGAAAGCTTCTC	0.318000													13	124					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43205702	43205702	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43205702G>A	ENST00000255226.6	+	3	1021	c.205G>A	c.(205-207)Gaa>Aaa	p.E69K	SLC14A2_ENST00000586448.1_Missense_Mutation_p.E69K	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	69						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AAAGCTCAATGAAAGGAGTAA	0.498000													14	46					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39085814	39085814	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:39085814G>A	ENST00000295373.6	-	6	1702	c.1576C>T	c.(1576-1578)Cga>Tga	p.R526*	DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	526							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TGTTTCATTCGGAACTGCTTG	0.413000													86	198					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176721426	176721426	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176721426C>T	ENST00000439151.2	+	23	7102	c.7057C>T	c.(7057-7059)Cct>Tct	p.P2353S	NSD1_ENST00000361032.4_Missense_Mutation_p.P2250S|NSD1_ENST00000354179.4_Missense_Mutation_p.P2084S|NSD1_ENST00000347982.4_Missense_Mutation_p.P2084S	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2353	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		ACTGGAAAGACCTCTGGGGAC	0.592000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			13	45					0	0	1	0	0
MS4A3	932	broad.mit.edu	37	11	59828646	59828646	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59828646G>A	ENST00000278865.3	+	2	86	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	MS4A3_ENST00000526199.1_3'UTR|MS4A3_ENST00000395032.2_Intron|MS4A3_ENST00000358152.2_Missense_Mutation_p.E5K|MS4A3_ENST00000534744.1_Missense_Mutation_p.E5K	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	5						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				GGCCTCCCACGAAGTTGATAA	0.483000													25	67					0	0	1	0	0
EPS8L2	64787	broad.mit.edu	37	11	723306	723306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:723306C>T	ENST00000533256.1	+	16	1782	c.1407C>T	c.(1405-1407)acC>acT	p.T469T	EPS8L2_ENST00000526198.1_Silent_p.T485T|EPS8L2_ENST00000530636.1_Silent_p.T469T|EPS8L2_ENST00000318562.8_Silent_p.T469T|AP006621.9_ENST00000527021.2_RNA			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	469						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGAGCCCACCCCCCCGGGGG	0.582000											OREG0020659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	71					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52927008	52927008	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:52927008C>T	ENST00000295213.4	+	3	628	c.254C>T	c.(253-255)tCc>tTc	p.S85F	SPATA18_ENST00000506829.1_Intron|SPATA18_ENST00000419395.2_Missense_Mutation_p.S85F	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	85					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CTGGAGGCTTCCTTTACTGCT	0.478000													29	56					0	0	1	0	0
ITGBL1	9358	broad.mit.edu	37	13	102250508	102250508	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:102250508G>A	ENST00000376180.3	+	7	1093	c.874G>A	c.(874-876)Gga>Aga	p.G292R	ITGBL1_ENST00000376162.3_Missense_Mutation_p.G199R|ITGBL1_ENST00000545560.2_Missense_Mutation_p.G151R	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	292	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity	p.G292*(1)		breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGAAGGTCATGGACAGTGTAA	0.428000													26	81					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13794063	13794063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13794063G>A	ENST00000265104.4	-	48	8096	c.7992C>T	c.(7990-7992)atC>atT	p.I2664I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2664	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCCACTCATTGATTATTGGCA	0.323000									Kartagener syndrome				31	58					0	0	1	0	0
KIFC1	3833	broad.mit.edu	37	6	33373143	33373143	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:33373143C>T	ENST00000428849.2	+	7	1721	c.1271C>T	c.(1270-1272)cCt>cTt	p.P424L		NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	424	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						GAGGGTGGGCCTGGGGGAGAC	0.602000													21	64					0	0	1	0	0
FGGY	55277	broad.mit.edu	37	1	60228238	60228238	+	Silent	SNP	G	G	A	rs137970847	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60228238G>A	ENST00000371218.4	+	17	1894	c.1710G>A	c.(1708-1710)gcG>gcA	p.A570A	FGGY_ENST00000303721.7_Silent_p.A546A|RP4-782L23.2_ENST00000443012.1_RNA|FGGY_ENST00000371210.1_Silent_p.A247A|FGGY_ENST00000371212.1_Silent_p.A458A	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	546					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					AGTATTTGGCGATCATGAATG	0.403000													8	30					0	0	1	0	0
ERRFI1	54206	broad.mit.edu	37	1	8073809	8073809	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8073809G>T	ENST00000377482.5	-	4	1073	c.850C>A	c.(850-852)Ccc>Acc	p.P284T	ERRFI1_ENST00000474874.1_Intron|ERRFI1_ENST00000469499.1_3'UTR|ERRFI1_ENST00000467067.1_3'UTR	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	284					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		ACTCTGGGGGGAACCTCAGGT	0.483000													49	106					2.81731e-22	2.8354e-22	1	1	0
ADAM32	203102	broad.mit.edu	37	8	39114774	39114774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39114774C>T	ENST00000379907.4	+	19	2201	c.2074C>T	c.(2074-2076)Cct>Tct	p.P692S	ADAM32_ENST00000437682.2_Missense_Mutation_p.P593S|ADAM32_ENST00000519315.1_Missense_Mutation_p.P586S	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	692					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.P691S(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CATTGCTCTTCCTATTCTCAT	0.378000													25	75					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40367848	40367848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40367848G>A	ENST00000221347.6	-	29	13119	c.13112C>T	c.(13111-13113)tCc>tTc	p.S4371F		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4371	TIL 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGGTGCAGGGGACGGACAGCT	0.622000													28	46					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994117	140994117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140994117C>T	ENST00000285879.4	+	4	1213	c.927C>T	c.(925-927)tcC>tcT	p.S309S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	309				SSS -> PSF (in Ref. 2; AAC24227).			protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTGAGCTCCTCCTCCTCCT	0.478000										HNSCC(15;0.026)			135	126					0	0	1	0	0
OR5F1	338674	broad.mit.edu	37	11	55762066	55762066	+	Silent	SNP	G	G	A	rs139328258		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55762066G>A	ENST00000278409.1	-	1	35	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					CCAATAGGACGAACTCAGTCA	0.338000													27	84					0	0	1	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154987313	154987313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154987313C>T	ENST00000368426.3	+	3	314	c.177C>T	c.(175-177)ttC>ttT	p.F59F	ZBTB7B_ENST00000292176.2_Silent_p.F59F|ZBTB7B_ENST00000535420.1_Silent_p.F59F|ZBTB7B_ENST00000487542.1_3'UTR|ZBTB7B_ENST00000417934.2_Silent_p.F93F	NM_001256455.1	NP_001243384.1	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	59	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)	29	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCCACTACTTCAAGAAGCTTT	0.652000													10	122					0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38395848	38395848	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:38395848C>T	ENST00000377698.3	+	2	256	c.103C>T	c.(103-105)Ccc>Tcc	p.P35S		NM_000692.4	NP_000683.3	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1 family, member B1	35					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	CCCAGACATCCCCTACAACCA	0.612000													21	55					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111343190	111343190	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111343190C>T	ENST00000352690.4	+	10	1500	c.1260C>T	c.(1258-1260)tcC>tcT	p.S420S	CD96_ENST00000283285.5_Silent_p.S436S	NM_005816.4	NP_005807.1	P40200	TACT_HUMAN	CD96 molecule	436	Pro/Ser/Thr-rich.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(4)|liver(2)|lung(14)|skin(5)	35						CCAGCAATTCCAGTATGACTA	0.393000									Opitz Trigonocephaly syndrome				25	87					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141128790	141128790	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141128790C>T	ENST00000389484.3	-	70	11804	c.10833G>A	c.(10831-10833)ttG>ttA	p.L3611L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3611	LDL-receptor class A 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATTACATTTCAAAGATGCTG	0.303000										TSP Lung(27;0.18)			15	33					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77407037	77407037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77407037G>A	ENST00000560626.2	-	7	5177	c.4702C>T	c.(4702-4704)Ccc>Tcc	p.P1568S	PEAK1_ENST00000312493.4_Missense_Mutation_p.P1568S			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1568	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										AGGATCTCGGGGTCCACCAGA	0.537000													43	149					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101624234	101624234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101624234C>T	ENST00000311812.2	-	7	755	c.605G>A	c.(604-606)cGa>cAa	p.R202Q	SNX31_ENST00000428383.2_Missense_Mutation_p.R103Q	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	202					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TTACCACTTTCGGAGTCCAAC	0.468000													16	75					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110474031	110474031	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110474031G>A	ENST00000378402.5	+	48	7381	c.7277G>A	c.(7276-7278)gGa>gAa	p.G2426E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2426					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTCTCCAAGGAAAGTTTGGA	0.368000										HNSCC(38;0.096)			5	21					0	0	1	0	0
MPZ	4359	broad.mit.edu	37	1	161276165	161276165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161276165G>A	ENST00000533357.1	-	4	604	c.538C>T	c.(538-540)Cgg>Tgg	p.R180W	MPZ_ENST00000360451.6_Missense_Mutation_p.R190W|MPZ_ENST00000526189.1_5'UTR|MPZ_ENST00000491222.2_5'UTR|MPZ_ENST00000336559.4_Missense_Mutation_p.R180W	NM_000530.6	NP_000521.2	P25189	MYP0_HUMAN	myelin protein zero	180					synaptic transmission	integral to plasma membrane	structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	10	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAGCAGTACCGAACCACGTAG	0.647000													42	85					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	234112995	234112995	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234112995G>A	ENST00000359570.5	+	28	3163	c.3163G>A	c.(3163-3165)Gag>Aag	p.1055_1055insK	INPP5D_ENST00000455936.2_Missense_Mutation_p.819_819insK|INPP5D_ENST00000450745.1_Missense_Mutation_p.819_819insK			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	0	Pro-rich.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CAAAGCCCAGGAGGCTGATCG	0.711000													17	38					0	0	1	0	0
SLC1A1	6505	broad.mit.edu	37	9	4544603	4544603	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:4544603A>G	ENST00000262352.3	+	2	364	c.128A>G	c.(127-129)aAc>aGc	p.N43S		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	43					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	GAACACAGCAACCTCTCAACT	0.388000													23	118					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187023	123187023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123187023G>A	ENST00000328880.5	-	1	867	c.808C>T	c.(808-810)Cgc>Tgc	p.R270C	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	270					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	TCCACCGAGCGGTACACTTCA	0.552000													6	42					0	0	1	0	0
FAM188B	84182	broad.mit.edu	37	7	30830929	30830929	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:30830929C>T	ENST00000265299.6	+	5	889	c.812C>T	c.(811-813)tCc>tTc	p.S271F	INMT-FAM188B_ENST00000458257.1_3'UTR	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	271										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TCCAGGACCTCCCTGGGTCAG	0.607000													39	74					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71101166	71101166	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71101166G>A	ENST00000288168.10	-	15	2166	c.2153C>T	c.(2152-2154)cCt>cTt	p.P718L	HYDIN_ENST00000538248.1_Intron|HYDIN_ENST00000321489.5_Intron|HYDIN_ENST00000393567.2_Intron|HYDIN_ENST00000448691.1_Intron|HYDIN_ENST00000541601.1_Intron|HYDIN_ENST00000448089.2_Intron|HYDIN_ENST00000393550.2_Intron			Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	0										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GGGCGACTCAGGAGAAGAGCA	0.587000													12	14					0	0	1	0	0
PRIMA1	145270	broad.mit.edu	37	14	94187839	94187839	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94187839C>T	ENST00000393140.1	-	5	515	c.413G>A	c.(412-414)aGt>aAt	p.S138N	PRIMA1_ENST00000316227.3_3'UTR|PRIMA1_ENST00000393143.1_Missense_Mutation_p.S138N	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	138					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		CTGCGAAGCACTCATGGGATA	0.582000													11	54					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41582036	41582036	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41582036C>T	ENST00000396942.1	-	7	732	c.649G>A	c.(649-651)Gag>Aag	p.E217K	ANK1_ENST00000352337.4_Missense_Mutation_p.E217K|ANK1_ENST00000396945.1_Missense_Mutation_p.E217K|ANK1_ENST00000289734.7_Missense_Mutation_p.E217K|ANK1_ENST00000379758.2_Missense_Mutation_p.E217K|ANK1_ENST00000265709.8_Missense_Mutation_p.E250K|ANK1_ENST00000347528.4_Missense_Mutation_p.E217K			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	217	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TTGAGGTTCTCGTAGTGAGCC	0.567000													3	5					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41008108	41008108	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41008108G>A	ENST00000352632.3	+	9	1057	c.971G>A	c.(970-972)tGg>tAg	p.W324*	SPTBN4_ENST00000344104.3_Nonsense_Mutation_p.W324*|SPTBN4_ENST00000595535.1_Nonsense_Mutation_p.W324*|SPTBN4_ENST00000598249.1_Nonsense_Mutation_p.W324*|SPTBN4_ENST00000338932.3_Nonsense_Mutation_p.W324*			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	324					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGCTGGCCTGGATCCACCGC	0.582000													30	76					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152327273	152327273	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152327273A>T	ENST00000388718.5	-	3	3061	c.2989T>A	c.(2989-2991)Tct>Act	p.S997T	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	997	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATAATTAGACTGACTTGAT	0.488000													160	390					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61391751	61391751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61391751C>T	ENST00000424789.2	+	8	944	c.940C>T	c.(940-942)Cgc>Tgc	p.R314C	TANC2_ENST00000389520.4_Missense_Mutation_p.R314C|AC037445.1_ENST00000581421.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	314							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CCTTTCAGTTCGCTTTGCACC	0.438000													24	40					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613867	179613867	+	Silent	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179613867T>A	ENST00000360870.5	-	46	13482	c.13260A>T	c.(13258-13260)ccA>ccT	p.P4420P	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	548	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGAATATTTGGTAAATAGT	0.343000													23	62					0	0	1	0	0
ECE1	1889	broad.mit.edu	37	1	21605853	21605853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21605853G>A	ENST00000357071.4	-	1	189	c.75C>T	c.(73-75)tcC>tcT	p.S25S	ECE1_ENST00000374893.6_Intron|ECE1_ENST00000436918.2_Intron|ECE1_ENST00000415912.2_Intron|ECE1_ENST00000264205.6_Intron	NM_001113347.1	NP_001106818.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	0					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		GGAGGGGCGGGGAAGACGTGA	0.701000													23	47					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	318966	318966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:318966G>A	ENST00000428720.1	-	3	930	c.187C>T	c.(187-189)Ccc>Tcc	p.P63S	SLC6A12_ENST00000424061.2_Missense_Mutation_p.P63S|SLC6A12_ENST00000536824.1_Missense_Mutation_p.P63S|SLC6A12_ENST00000397296.2_Missense_Mutation_p.P63S|SLC6A12_ENST00000359674.4_Missense_Mutation_p.P63S	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	63					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			CAGAGATAGGGAAACCTCCAG	0.577000													33	138					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	595460	595460	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:595460C>T	ENST00000381578.1	+	3	1076	c.385C>T	c.(385-387)Ctg>Ttg	p.L129L	SHOX_ENST00000334060.3_Silent_p.L129L|SHOX_ENST00000554971.1_Silent_p.L129L|SHOX_ENST00000381575.1_Silent_p.L129L	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	129					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCTGGAGCAGCTGAACGAGCT	0.637000													16	23					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74973960	74973960	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74973960C>T	ENST00000261978.4	-	26	4215	c.3829G>A	c.(3829-3831)Gaa>Aaa	p.E1277K	LTBP2_ENST00000556690.1_Intron	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1277	Cys-rich.|EGF-like 14; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGGCTGTTTTCACACTTCCAG	0.592000													27	87					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107430068	107430068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107430068G>A	ENST00000340010.5	-	6	820	c.636C>T	c.(634-636)ggC>ggT	p.G212G	SLC26A3_ENST00000422236.2_Silent_p.G177G	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	212					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						CAGTAGTGAAGCCACTGATGA	0.423000													7	37					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228210584	228210584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228210584C>T	ENST00000284523.1	+	2	366	c.288C>T	c.(286-288)gcC>gcT	p.A96A	WNT3A_ENST00000366753.2_Silent_p.A96A	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	96					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				ACAGCCTGGCCATCTTCGGGC	0.652000													28	40					0	0	1	0	0
C10orf118	55088	broad.mit.edu	37	10	115889665	115889665	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115889665G>A	ENST00000369287.3	-	13	2433	c.2167C>T	c.(2167-2169)Cgt>Tgt	p.R723C	C10orf118_ENST00000543782.1_Missense_Mutation_p.R321C	NM_018017.2	NP_060487.2	Q7Z3E2	CJ118_HUMAN	chromosome 10 open reading frame 118	723	Ser-rich.									NS(1)|autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(2)	24		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		GAACTAGAACGACTTCCCATG	0.368000													38	92					0	0	1	0	0
RIOK3	8780	broad.mit.edu	37	18	21044179	21044179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21044179C>T	ENST00000339486.3	+	4	952	c.335C>T	c.(334-336)tCc>tTc	p.S112F	RIOK3_ENST00000577501.1_Missense_Mutation_p.S112F|RIOK3_ENST00000581585.1_Missense_Mutation_p.S96F	NM_003831.3	NP_003822.2	O14730	RIOK3_HUMAN	RIO kinase 3	112					chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(2)	10	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GTTTCCATTTCCTTTGAAAAT	0.373000													9	42					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117639386	117639386	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117639386C>T	ENST00000368508.3	-	37	6168	c.5970G>A	c.(5968-5970)gaG>gaA	p.E1990E	GOPC_ENST00000467125.1_5'UTR|ROS1_ENST00000368507.3_Silent_p.E1984E	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1990	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ATTCAATCTTCTCCTGGTCTG	0.393000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								24	29					0	0	1	0	0
NUGGC	389643	broad.mit.edu	37	8	27925193	27925193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27925193C>T	ENST00000413272.2	-	6	691	c.549G>A	c.(547-549)gaG>gaA	p.E183E	NUGGC_ENST00000341513.6_Silent_p.E183E	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		ACGCATCTGCCTCTTCTCTGC	0.537000													9	34					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43274922	43274922	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43274922G>A	ENST00000422911.1	-	5	503	c.402C>T	c.(400-402)ttC>ttT	p.F134F	PRDM15_ENST00000269844.3_Silent_p.F463F|PRDM15_ENST00000538201.1_Silent_p.F97F|PRDM15_ENST00000398548.1_Silent_p.F134F|PRDM15_ENST00000447207.2_Silent_p.F97F			P57071	PRD15_HUMAN	PR domain containing 15	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						CGTCCTTCTGGAACACCTGAA	0.612000													9	29					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51133251	51133251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51133251C>T	ENST00000338916.4	-	3	1485	c.852G>A	c.(850-852)cgG>cgA	p.R284R	SYT3_ENST00000544769.1_Silent_p.R284R|SYT3_ENST00000593901.1_Silent_p.R284R|SYT3_ENST00000600079.1_Silent_p.R284R	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	284						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CCCCACCGCTCCGCCGGCCAC	0.662000													26	69					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58563491	58563491	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:58563491G>A	ENST00000267485.7	-	5	2234	c.2040C>T	c.(2038-2040)acC>acT	p.T680T		NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	680						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						GCACCTGGTAGGTAGCTCCCT	0.527000													19	34					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35857148	35857148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35857148C>T	ENST00000303115.3	+	1	198	c.69C>T	c.(67-69)ggC>ggT	p.G23G	IL7R_ENST00000506850.1_Silent_p.G23G|IL7R_ENST00000343305.4_Silent_p.G23G|IL7R_ENST00000511982.1_Silent_p.G23G|IL7R_ENST00000511031.1_Intron	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	23					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GAGAAAGTGGCTATGCTCAAA	0.383000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						80	166					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11505674	11505674	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11505674G>A	ENST00000379237.1	-	15	1647	c.1253C>T	c.(1252-1254)cCc>cTc	p.P418L	USP6NL_ENST00000277575.5_Missense_Mutation_p.P435L	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	418						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						CCTGCTCTGGGGGTGCGGGGA	0.652000													16	38					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160917803	160917803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160917803G>A	ENST00000368029.3	-	7	798	c.741C>T	c.(739-741)ttC>ttT	p.F247F	RP11-544M22.1_ENST00000356006.3_RNA|ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	247	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GGAACTGAACGAATCCTGCAA	0.468000													23	76					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187479	123187479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123187479G>A	ENST00000328880.5	-	1	411	c.352C>T	c.(352-354)Ctc>Ttc	p.L118F	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	118					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	ACCACCGTGAGGAAGATGATG	0.562000													21	79					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56243490	56243490	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56243490G>A	ENST00000332836.2	-	2	1734	c.1707C>T	c.(1705-1707)ttC>ttT	p.F569F		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	569						cytoplasm	ATP binding	p.F569F(1)		NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CAATATAAATGAAAACTTCTT	0.343000													18	45					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85449568	85449568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:85449568G>A	ENST00000393217.2	+	8	1058	c.997G>A	c.(997-999)Gaa>Aaa	p.E333K		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	333	Glu-rich.							p.E333*(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		acaaaaggaggaagaaaatcg	0.333000													12	13					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73905028	73905028	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:73905028C>T	ENST00000342056.2	+	15	3145	c.2747C>T	c.(2746-2748)gCc>gTc	p.A916V	KCNQ5_ENST00000414165.2_Missense_Mutation_p.A787V|KCNQ5_ENST00000403813.2_Missense_Mutation_p.A888V|KCNQ5_ENST00000402622.2_Missense_Mutation_p.A907V|KCNQ5_ENST00000370398.1_Missense_Mutation_p.A897V|KCNQ5_ENST00000355635.3_Missense_Mutation_p.A898V|KCNQ5_ENST00000355194.4_Missense_Mutation_p.A897V	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	897					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AGGGAAGCTGCCTTTGCATCA	0.498000													11	144					0	0	1	0	0
SH2D7	646892	broad.mit.edu	37	15	78393515	78393515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78393515G>A	ENST00000328828.5	+	5	920	c.920G>A	c.(919-921)gGt>gAt	p.G307D	SH2D7_ENST00000409568.2_Missense_Mutation_p.G171D	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	307										endometrium(2)|kidney(2)|lung(3)	7						CCAGACCAGGGTCCCACAGAG	0.607000													5	23					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50217819	50217819	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50217819G>A	ENST00000338821.5	-	28	3339	c.3075C>T	c.(3073-3075)ctC>ctT	p.L1025L	ATP9A_ENST00000311637.5_Silent_p.L889L|ATP9A_ENST00000402822.1_Silent_p.L904L	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	1025					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CATAGAGGGGGAGGCAGCTGA	0.567000													18	35					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52131211	52131211	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52131211G>A	ENST00000222107.4	-	5	1011	c.873C>T	c.(871-873)acC>acT	p.T291T	SIGLEC5_ENST00000429354.3_Silent_p.T291T|SIGLEC5_ENST00000534261.2_Silent_p.T291T|SIGLEC5_ENST00000599649.1_Silent_p.T291T|SIGLEC5_ENST00000570106.2_Silent_p.T291T			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	291	Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TGGAGATGGGGGTGGCGTTCA	0.642000													43	112					0	0	1	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070619	32070619	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32070619C>T	ENST00000566806.1	-	0	499																											TGCAAGGCTTCTGGATACACC	0.537000													11	74					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35802490	35802490	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35802490G>A	ENST00000400441.3	-	3	286	c.287C>T	c.(286-288)cCc>cTc	p.P96L	MROH8_ENST00000441008.2_Missense_Mutation_p.P82L|MROH8_ENST00000217333.8_Missense_Mutation_p.P11L					maestro heat-like repeat family member 8																		ATAGGCACAGGGGATCACTAC	0.393000													8	27					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70501251	70501251	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70501251C>T	ENST00000260128.4	+	8	1326	c.609C>T	c.(607-609)ttC>ttT	p.F203F	SULF1_ENST00000458141.2_Silent_p.F203F|SULF1_ENST00000419716.3_Silent_p.F203F|SULF1_ENST00000402687.4_Silent_p.F203F	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	203					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTAATTACTTCAAAATGTCTA	0.433000													20	71					0	0	1	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111037	7111037	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7111037G>A	ENST00000306904.5	+	1	873	c.686G>A	c.(685-687)cGg>cAg	p.R229Q		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	229	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding	p.R229Q(1)		NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CGCGAACCCCGGGGTTTTGCC	0.701000													13	19					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57069596	57069596	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57069596G>A	ENST00000532437.1	-	7	5097	c.4786C>T	c.(4786-4788)Ctg>Ttg	p.L1596L	TNKS1BP1_ENST00000358252.3_Silent_p.L1596L			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1596	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GCCTCCGACAGGCCCAAGGTA	0.597000													35	86					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580800	140580800	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140580800C>T	ENST00000354757.3	+	1	1453	c.1453C>T	c.(1453-1455)Cag>Tag	p.Q485*	PCDHB11_ENST00000536699.1_Nonsense_Mutation_p.Q120*	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		485	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCAACGCCCAGGTCAACTA	0.632000													75	202					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77377329	77377329	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77377329C>T	ENST00000451710.3	-	26	4495	c.4258G>A	c.(4258-4260)Gca>Aca	p.A1420T	TRPM6_ENST00000376864.4_Missense_Mutation_p.A1420T|TRPM6_ENST00000449912.2_Missense_Mutation_p.A1415T|TRPM6_ENST00000360774.1_Missense_Mutation_p.A1420T|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.A1415T|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1420					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						ACTTGCTCTGCCTTGTCTTGT	0.512000													27	63					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028767	37028767	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37028767C>T	ENST00000358047.3	+	1	2336	c.2284C>T	c.(2284-2286)Ctc>Ttc	p.L762F		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	762										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CGTATCTCATCTCCGCCCGGA	0.632000													41	27					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45479473	45479473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45479473G>A	ENST00000334940.6	+	5	446	c.312G>A	c.(310-312)aaG>aaA	p.K104K	RASSF4_ENST00000472561.1_Intron|RASSF4_ENST00000340258.4_Silent_p.K95K|RASSF4_ENST00000374417.2_Intron			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	95					cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						TTTTCAGAAAGGAGCCATCGC	0.602000													3	7					0	0	1	0	0
TM7SF2	7108	broad.mit.edu	37	11	64882811	64882811	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64882811G>A	ENST00000279263.7	+	8	1080	c.918G>A	c.(916-918)ggG>ggA	p.G306G	TM7SF2_ENST00000540748.1_Silent_p.G190G|TM7SF2_ENST00000345348.5_Intron	NM_003273.2	NP_003264.2	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	306					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCTTCCGTGGGGCGAATTCCC	0.572000													46	115					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2020477	2020477	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2020477G>A	ENST00000262113.4	+	9	987	c.846G>A	c.(844-846)gaG>gaA	p.E282E	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	282	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AGTTTTTGGAGAAGTTTGGGG	0.597000													16	48					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42050647	42050647	+	Silent	SNP	G	G	A	rs141964626		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42050647G>A	ENST00000220809.4	-	2	313	c.57C>T	c.(55-57)ttC>ttT	p.F19F	PLAT_ENST00000429710.2_Silent_p.F19F|PLAT_ENST00000429089.2_Silent_p.F19F|PLAT_ENST00000352041.3_Silent_p.F19F|PLAT_ENST00000270189.6_Silent_p.F19F|PLAT_ENST00000524009.1_Silent_p.F19F|PLAT_ENST00000519510.1_Silent_p.F19F	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	19					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TGGGCGAAACGAAGACTGCTC	0.567000													25	57					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7696348	7696348	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7696348G>A	ENST00000572933.1	+	48	8854	c.7394G>A	c.(7393-7395)cGa>cAa	p.R2465Q	DNAH2_ENST00000389173.2_Missense_Mutation_p.R2465Q			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2465	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTTGAGAAGCGAACCAAGGGT	0.512000													36	56					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39927939	39927939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39927939C>T	ENST00000393931.3	-	2	286	c.168G>A	c.(166-168)aaG>aaA	p.K56K	JUP_ENST00000310706.5_Silent_p.K56K|JUP_ENST00000540235.1_Silent_p.K56K|JUP_ENST00000393930.1_Silent_p.K56K	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	56					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		TGGTGGTTTTCTTGAGCGTGT	0.637000													33	33					0	0	1	0	0
IFITM5	387733	broad.mit.edu	37	11	298534	298534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:298534G>A	ENST00000382614.2	-	2	401	c.366C>T	c.(364-366)ttC>ttT	p.F122F		NM_001025295.1	NP_001020466.1	A6NNB3	IFM5_HUMAN	interferon induced transmembrane protein 5	122					multicellular organismal development|regulation of bone mineralization|response to biotic stimulus	integral to membrane|plasma membrane				lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.73e-28)|Epithelial(43;3.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.14e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0328)|LUSC - Lung squamous cell carcinoma(625;0.122)		ACTTGGTGCTGAAGAAGGCGG	0.672000													13	23					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49227424	49227424	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:49227424C>T	ENST00000327979.2	-	6	791	c.380G>A	c.(379-381)aGg>aAg	p.R127K	FAM65C_ENST00000045083.2_Missense_Mutation_p.R127K|FAM65C_ENST00000535356.1_Missense_Mutation_p.R131K			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	127										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCGAATGTGCCTTTCCACACA	0.597000													33	86					0	0	1	0	0
ART5	116969	broad.mit.edu	37	11	3661201	3661201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3661201C>T	ENST00000397068.3	-	2	850	c.458G>A	c.(457-459)gGa>gAa	p.G153E	ART5_ENST00000359918.4_Missense_Mutation_p.G153E|ART5_ENST00000397067.3_Missense_Mutation_p.G153E	NM_053017.3	NP_443750.2	Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5	153						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)|ovary(1)	11		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCCCCAGGTCCCCTGCTGCA	0.637000													26	38					0	0	1	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23438988	23438988	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:23438988C>T	ENST00000526079.1	+	0	571					NR_027407.1|NR_033350.1																						CCCCAGAGTCCACCCCATCCC	0.632000													3	9					0	0	1	0	0
BHLHE22	27319	broad.mit.edu	37	8	65493764	65493764	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:65493764C>T	ENST00000321870.1	+	1	951	c.417C>T	c.(415-417)gcC>gcT	p.A139A	RP11-21C4.1_ENST00000517909.1_RNA	NM_152414.4	NP_689627.1	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix family, member e22	139	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	5						GCTCGGTGGCCGAGAGCAGCG	0.751000													4	3					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034562	52034562	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52034562G>A	ENST00000346477.3	-	2	347	c.279C>T	c.(277-279)ttC>ttT	p.F93F	SIGLEC6_ENST00000359982.4_Silent_p.F93F|SIGLEC6_ENST00000391797.3_Silent_p.F93F|SIGLEC6_ENST00000343300.4_Silent_p.F93F|SIGLEC6_ENST00000436458.1_Silent_p.F57F|SIGLEC6_ENST00000425629.3_Silent_p.F93F	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	93	Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		AGAGGAGGTGGAATCGGCCCC	0.552000													35	108					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234749364	234749364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234749364G>A	ENST00000411486.2	-	8	2127	c.2062C>T	c.(2062-2064)Ccc>Tcc	p.P688S	HJURP_ENST00000432087.1_Missense_Mutation_p.P634S|HJURP_ENST00000441687.1_Missense_Mutation_p.P603S	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	688					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		GAGCCCTGGGGTTCTGATAGC	0.592000													29	100					0	0	1	0	0
SHC2	25759	broad.mit.edu	37	19	422388	422388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:422388G>A	ENST00000264554.6	-	11	1377	c.1378C>T	c.(1378-1380)Ccc>Tcc	p.P460S		NM_012435.2	NP_036567.2	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing) transforming protein 2	460	CH1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol				endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTCCAAGGGAAGAGGGGCT	0.687000													6	10					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604454	140604454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140604454C>T	ENST00000239449.4	+	1	1377	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	PCDHB14_ENST00000515856.2_Silent_p.F306F	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		459	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.607000													80	223					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457833	45457833	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45457833G>A	ENST00000548424.1	+	0	448																											GCTTTGTTTAGGCGAAAGGTC	0.458000													38	130					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924799	188924799	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:188924799C>T	ENST00000326866.4	+	4	1246	c.838C>T	c.(838-840)Caa>Taa	p.Q280*	ZFP42_ENST00000509524.1_Nonsense_Mutation_p.Q280*	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	280					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GTGTCCCTTTCAAGGCTGCAA	0.483000													24	34					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50208333	50208333	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50208333C>T	ENST00000392518.4	+	9	1213	c.841C>T	c.(841-843)Ctg>Ttg	p.L281L	CPT1C_ENST00000323446.5_Silent_p.L281L|CPT1C_ENST00000598293.1_Silent_p.L281L|CPT1C_ENST00000354199.5_Silent_p.L281L|CPT1C_ENST00000405931.2_Silent_p.L270L	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	281					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TGCCCTCCTCCTGTACCGCCA	0.652000													22	76					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7862555	7862555	+	Missense_Mutation	SNP	C	C	T	rs150526011	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7862555C>T	ENST00000283147.6	+	4	1187	c.1028C>T	c.(1027-1029)gCc>gTc	p.A343V		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	343			A -> D (in a colorectal cancer sample; somatic mutation).		BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity	p.A343D(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					CACCCCCGAGCCGCAGGCCTG	0.532000													55	134					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280694	152280694	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152280694G>A	ENST00000368799.1	-	3	6703	c.6668C>T	c.(6667-6669)tCa>tTa	p.S2223L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2223	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCCACCAGTGAGTGTCTAGA	0.542000									Ichthyosis				122	266					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559762	140559762	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140559762G>A	ENST00000239444.2	+	1	2392	c.2147G>A	c.(2146-2148)aGg>aAg	p.R716K		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		716					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGCTGTGTAGGAGGAGCAGG	0.657000													22	206					0	0	1	0	0
GPR148	344561	broad.mit.edu	37	2	131487659	131487659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131487659C>T	ENST00000309926.4	+	1	1017	c.935C>T	c.(934-936)cCc>cTc	p.P312L		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	312						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					ATGATGCTTCCCCGTGCCATG	0.592000													16	54					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167159920	167159920	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:167159920C>T	ENST00000476257.1	-	10	1493	c.1195G>A	c.(1195-1197)Gga>Aga	p.G399R	SERPINI2_ENST00000471111.1_Missense_Mutation_p.G399R|SERPINI2_ENST00000264677.4_Missense_Mutation_p.G399R|SERPINI2_ENST00000461846.1_Missense_Mutation_p.G399R			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	399					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						AAATCTCTTCCTTTTATCTCC	0.328000													16	31					0	0	1	0	0
DGAT2L6	347516	broad.mit.edu	37	X	69419661	69419661	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:69419661G>A	ENST00000333026.3	+	3	296		c.e3-1			NM_198512.1	NP_940914.1	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6						lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(1)	12						TGTACCCACAGGTGGCAGGCG	0.552000													13	15					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75192536	75192536	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:75192536G>A	ENST00000336926.6	-	10	861	c.835C>T	c.(835-837)Ctg>Ttg	p.L279L	HIP1_ENST00000434438.2_Silent_p.L279L	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	279					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						AAGTACTGCAGGTTGCTGGAG	0.582000			T	PDGFRB	CMML								9	72					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584834	1584834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1584834G>A	ENST00000381297.4	-	2	828	c.618C>T	c.(616-618)ttC>ttT	p.F206F		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	206						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGGTGATCACGAACGGGATGA	0.647000			T	CRLF2	"""B-ALL, Downs associated ALL"""								13	39					0	0	1	0	0
RGS4	5999	broad.mit.edu	37	1	163042253	163042253	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:163042253C>T	ENST00000421743.2	+	3	564	c.404C>T	c.(403-405)tCc>tTc	p.S135F	RGS4_ENST00000531057.1_Missense_Mutation_p.S38F|RGS4_ENST00000491263.1_3'UTR|RGS4_ENST00000527809.1_Missense_Mutation_p.S20F|RGS4_ENST00000367909.6_Missense_Mutation_p.S38F|RGS4_ENST00000367908.4_Missense_Mutation_p.S38F|RGS4_ENST00000367906.3_Missense_Mutation_p.S20F	NM_001102445.2|NM_001113380.1	NP_001095915.1|NP_001106851.1	P49798	RGS4_HUMAN	regulator of G-protein signaling 4	38	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|upper_aerodigestive_tract(2)	21						CACAATTCTTCCCACAACAAG	0.383000													29	64					0	0	1	0	0
RABEPK	10244	broad.mit.edu	37	9	127990228	127990228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127990228C>T	ENST00000373538.3	+	6	876	c.566C>T	c.(565-567)cCt>cTt	p.P189L	RABEPK_ENST00000394125.4_Missense_Mutation_p.P189L|RABEPK_ENST00000394124.4_3'UTR|RABEPK_ENST00000259460.8_Missense_Mutation_p.P138L	NM_005833.3	NP_005824.2	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	189					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15						CTTGGAAATCCTCCATCTCCC	0.473000													26	56					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55539335	55539335	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55539335C>T	ENST00000219070.4	+	13	2473	c.1964C>T	c.(1963-1965)tCc>tTc	p.S655F	MMP2_ENST00000437642.2_Missense_Mutation_p.S605F|MMP2_ENST00000543485.1_Missense_Mutation_p.S579F|MMP2_ENST00000570308.1_Missense_Mutation_p.S579F	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	655	Hemopexin-like 4.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	AGCATCAAATCCGACTGGCTA	0.552000													57	89					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196659300	196659300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196659300C>T	ENST00000367429.4	+	9	1507	c.1267C>T	c.(1267-1269)Cca>Tca	p.P423S	CFH_ENST00000439155.2_Missense_Mutation_p.P423S|CFH_ENST00000359637.2_Missense_Mutation_p.P359S	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	423	Sushi 7.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						CTACGCTCTTCCAAAAGCGCA	0.418000													26	44					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531760	50531760	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50531760G>A	ENST00000374144.3	+	3	1458	c.1170G>A	c.(1168-1170)ggG>ggA	p.G390G	C10orf71_ENST00000323868.4_Silent_p.G390G			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	390										endometrium(1)	1						GCAAAAAAGGGAAAGAAAGTC	0.463000													28	85					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118516191	118516191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118516191C>T	ENST00000361417.2	+	17	3650	c.3239C>T	c.(3238-3240)cCc>cTc	p.P1080L	PHLDB1_ENST00000524713.1_Missense_Mutation_p.P223L|PHLDB1_ENST00000356063.5_Missense_Mutation_p.P1033L|PHLDB1_ENST00000527898.1_Missense_Mutation_p.P131L|PHLDB1_ENST00000534672.1_3'UTR	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	1080										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCAGCGGGCCCCTCGGGCTTC	0.672000													25	98					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	921181	921181	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:921181G>A	ENST00000262301.11	-	7	1076	c.1058C>T	c.(1057-1059)gCc>gTc	p.A353V	LMF1_ENST00000543238.1_Missense_Mutation_p.A116V|LMF1_ENST00000568897.1_Missense_Mutation_p.A136V|LMF1_ENST00000568268.1_5'UTR|LMF1_ENST00000399843.2_Missense_Mutation_p.A353V	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	353						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				CTCGGGCCGGGCCCCTCGGAT	0.672000													3	3					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29296878	29296878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29296878C>T	ENST00000331664.5	-	1	249	c.250G>A	c.(250-252)Ggc>Agc	p.G84S		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	84					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TTCCTTTTGCCTGAAGCAGGA	0.507000													17	165					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129712754	129712754	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:129712754G>A	ENST00000421865.2	+	36	5239	c.5190G>A	c.(5188-5190)agG>agA	p.R1730R		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1730	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AACTGAGGAGGAAAAATCTAG	0.353000													34	41					0	0	1	0	0
CD300A	11314	broad.mit.edu	37	17	72473661	72473661	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72473661G>A	ENST00000360141.3	+	4	908	c.620G>A	c.(619-621)tGg>tAg	p.W207*	CD300A_ENST00000310828.5_Nonsense_Mutation_p.W94*|CD300A_ENST00000361933.3_Intron|CD300A_ENST00000392625.3_Nonsense_Mutation_p.W94*|CD300A_ENST00000577511.1_Nonsense_Mutation_p.W77*	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	207					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						TTTCAGAAATGGATCAAAGGT	0.597000													6	35					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119929406	119929406	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119929406C>T	ENST00000361035.4	+	6	1045	c.762C>T	c.(760-762)atC>atT	p.I254I	HAO2_ENST00000325945.3_Silent_p.I241I	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	241	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		TCCAGGGTATCATTGTTTCCA	0.453000													33	95					0	0	1	0	0
VIPR1	7433	broad.mit.edu	37	3	42567411	42567411	+	Missense_Mutation	SNP	G	G	A	rs35925925		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42567411G>A	ENST00000433647.1	+	5	826	c.202G>A	c.(202-204)Ggc>Agc	p.G68S	VIPR1-AS1_ENST00000600342.1_RNA|VIPR1-AS1_ENST00000596630.1_RNA|VIPR1_ENST00000438259.2_5'UTR|VIPR1-AS1_ENST00000602176.1_RNA|VIPR1-AS1_ENST00000601312.1_RNA|VIPR1-AS1_ENST00000593611.1_RNA|VIPR1-AS1_ENST00000593621.1_RNA|VIPR1_ENST00000473575.1_3'UTR|VIPR1_ENST00000543411.1_Missense_Mutation_p.G62S|VIPR1-AS1_ENST00000452639.2_RNA|VIPR1-AS1_ENST00000598837.1_RNA|VIPR1_ENST00000325123.4_Missense_Mutation_p.G109S	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	109					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		CACCGACGAAGGCTGGACGCA	0.642000													4	11					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196737056	196737056	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196737056G>A	ENST00000312428.6	-	40	6651	c.6551C>T	c.(6550-6552)tCc>tTc	p.S2184F		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2184	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATGACACGGGAGAAATCACG	0.388000													13	165					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140729881	140729881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140729881C>T	ENST00000523390.1	+	1	54	c.54C>T	c.(52-54)ttC>ttT	p.F18F	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTTCCCTTCCTGCTGTCTT	0.522000											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	26					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	158334200	158334200	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:158334200C>T	ENST00000404321.2	-	1	98	c.99G>A	c.(97-99)gtG>gtA	p.V33V	PTPRN2_ENST00000389413.3_Intron|PTPRN2_ENST00000389416.4_Intron|PTPRN2_ENST00000389418.4_Intron|PTPRN2_ENST00000409483.1_Intron			Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	0						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AAACAAACATCACTTCCACCC	0.532000													30	88					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125833454	125833454	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125833454C>T	ENST00000393434.2	-	18	2377	c.2028G>A	c.(2026-2028)ggG>ggA	p.G676G	ALDH1L1_ENST00000273450.3_Silent_p.G686G|ALDH1L1_ENST00000393431.2_Intron|ALDH1L1_ENST00000472186.1_Silent_p.G676G|ALDH1L1_ENST00000452905.2_Silent_p.G575G	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	676	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GGGGTGACTTCCCGCCCAGTT	0.617000													37	73					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30433001	30433001	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30433001G>A	ENST00000375978.3	-	1	419	c.345C>T	c.(343-345)acC>acT	p.T115T		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	115					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						CTGTCTGCCGGGTGAAGCGGC	0.701000													10	32					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41084153	41084153	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:41084153C>T	ENST00000324545.7	+	40	7543	c.6910C>T	c.(6910-6912)Cgt>Tgt	p.R2304C	USP9X_ENST00000378308.2_Missense_Mutation_p.R2304C	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	2304					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CAAATTGCTTCGTTTTTGCTG	0.363000													21	85					0	0	1	0	0
CALML6	163688	broad.mit.edu	37	1	1848629	1848629	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1848629G>A	ENST00000307786.3	+	6	997	c.543G>A	c.(541-543)caG>caA	p.Q181Q		NM_138705.2	NP_619650.2	Q8TD86	CALL6_HUMAN	calmodulin-like 6	181						cytoplasm|nucleus	calcium ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(1)|prostate(2)	7	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.94e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.83e-23)|GBM - Glioblastoma multiforme(42;3.23e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		AGCTGATCCAGTAGGTGCAGC	0.667000													3	8					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19634720	19634720	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19634720C>T	ENST00000328041.6	+	7	824	c.627C>T	c.(625-627)tcC>tcT	p.S209S		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	209						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TGGCTCTTTCCTCCTGGTGCC	0.507000													11	78					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55815081	55815081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55815081G>A	ENST00000309383.1	+	12	1450	c.1173G>A	c.(1171-1173)ggG>ggA	p.G391G	BRSK1_ENST00000590333.1_Silent_p.G407G|BRSK1_ENST00000326848.7_Silent_p.G86G	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	391			G -> E (in a metastatic melanoma sample; somatic mutation).		establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCCGTCACGGGAAGCGGCGAC	0.622000													30	102					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156997953	156997953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156997953C>T	ENST00000257527.4	-	2	208	c.130G>A	c.(130-132)Gaa>Aaa	p.E44K	ADAM19_ENST00000394020.1_Missense_Mutation_p.E46K|ADAM19_ENST00000430702.2_5'UTR|ADAM19_ENST00000517905.1_Missense_Mutation_p.E44K	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	44					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGATAAGTTCATGCTGCAGC	0.483000													33	70					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114223968	114223968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114223968G>A	ENST00000357077.4	+	23	2574	c.2521G>A	c.(2521-2523)Gag>Aag	p.E841K	ANK2_ENST00000264366.6_Missense_Mutation_p.E841K|ANK2_ENST00000506722.1_Missense_Mutation_p.E820K|ANK2_ENST00000509550.1_Missense_Mutation_p.E50K|ANK2_ENST00000394537.3_Missense_Mutation_p.E841K	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	841					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GACGATGACTGAGGTTCTTGA	0.333000													31	95					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93979219	93979219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:93979219C>T	ENST00000369303.4	-	7	1793	c.1609G>A	c.(1609-1611)Gaa>Aaa	p.E537K		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	537						integral to plasma membrane	ATP binding|ephrin receptor activity	p.E537K(1)		NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CCTGTAGCTTCCTCTAGTGTA	0.363000													34	59					0	0	1	0	0
TES	26136	broad.mit.edu	37	7	115890401	115890401	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:115890401G>A	ENST00000358204.4	+	4	768	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	AC002066.1_ENST00000446355.2_RNA|TES_ENST00000537767.1_Intron|TES_ENST00000393481.2_Missense_Mutation_p.E176K|AC073130.3_ENST00000444244.1_RNA	NM_015641.3	NP_056456.1	Q9UGI8	TES_HUMAN	testis derived transcript (3 LIM domains)	185	PET.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding			endometrium(4)|large_intestine(4)|lung(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	12	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			ATATAAGAGCGAAGCTCTGGG	0.512000													26	52					0	0	1	0	0
DOC2A	8448	broad.mit.edu	37	16	30020383	30020383	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30020383G>A	ENST00000350119.4	-	5	651	c.461C>T	c.(460-462)cCc>cTc	p.P154L	DOC2A_ENST00000564979.1_Missense_Mutation_p.P154L|DOC2A_ENST00000564944.1_Missense_Mutation_p.P154L	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	154	C2 1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						ATTCCACACGGGATTCAGTGT	0.567000													8	51					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58639429	58639429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58639429C>T	ENST00000358781.2	-	3	403	c.93G>A	c.(91-93)atG>atA	p.M31I		NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	31					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		GGATGGTTTTCATGCTGAAGC	0.577000													59	146					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6729468	6729468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6729468C>T	ENST00000329858.4	-	2	1703	c.947G>A	c.(946-948)cGg>cAg	p.R316Q	LPAR5_ENST00000431922.1_Missense_Mutation_p.R316Q	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	316						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						GGTCCTGGCCCGGTGCGGAGT	0.721000													4	9					0	0	1	0	0
LETMD1	25875	broad.mit.edu	37	12	51442255	51442255	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51442255C>T	ENST00000418425.2	+	1	135	c.116C>T	c.(115-117)gCc>gTc	p.A39V	LETMD1_ENST00000550929.1_Intron|LETMD1_ENST00000547008.1_Missense_Mutation_p.A39V|LETMD1_ENST00000548516.1_Intron|LETMD1_ENST00000380123.2_Missense_Mutation_p.A39V|LETMD1_ENST00000552739.1_Missense_Mutation_p.A39V|LETMD1_ENST00000262055.4_Missense_Mutation_p.A39V	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	39	Required and sufficient for mitochondrial import.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						GCTTGGGGGGCCCCTCGGTGA	0.577000											OREG0021818	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	77					0	0	1	0	0
PHTF2	57157	broad.mit.edu	37	7	77569557	77569557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:77569557C>T	ENST00000416283.2	+	12	1702	c.1576C>T	c.(1576-1578)Cgc>Tgc	p.R526C	PHTF2_ENST00000248550.7_Missense_Mutation_p.R560C|PHTF2_ENST00000275575.7_Missense_Mutation_p.R522C|PHTF2_ENST00000424760.1_Missense_Mutation_p.R522C|PHTF2_ENST00000307305.8_Missense_Mutation_p.R522C|PHTF2_ENST00000422959.2_Missense_Mutation_p.R526C	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						TTTTGTGGTTCGCGTGTCTCT	0.338000													33	94					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35547981	35547981	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35547981C>T	ENST00000536438.1	-	10	1173	c.858G>A	c.(856-858)caG>caA	p.Q286Q	FKBP5_ENST00000357266.4_Silent_p.Q286Q|FKBP5_ENST00000540787.1_Silent_p.Q107Q|FKBP5_ENST00000539068.1_Silent_p.Q286Q	NM_001145775.1	NP_001139247.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	286					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						GAATCACCGCCTGCATGTATT	0.428000													22	246					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21158759	21158759	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21158759C>T	ENST00000377122.4	-	6	888	c.492G>A	c.(490-492)agG>agA	p.R164R	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377119.1_Silent_p.R164R	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	164					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GCACGTCTTTCCTATAAGAAA	0.363000													16	70					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	30054406	30054406	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:30054406G>A	ENST00000431530.3	+	8	3392	c.3334G>A	c.(3334-3336)Gag>Aag	p.E1112K	MTUS2-AS1_ENST00000323380.4_RNA|MTUS2_ENST00000380808.2_Missense_Mutation_p.E81K|MTUS2_ENST00000542829.1_5'UTR	NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	1102	Localization to the growing distal tip of microtubules.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GGAGCTGGAGGAGCGGCTGCA	0.632000													3	3					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57473361	57473361	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:57473361G>A	ENST00000374900.4	+	9	1237	c.1116_splice	c.e9-1	p.E373_splice	FAAH2_ENST00000491179.1_Intron	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	373						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						TCAATCTCAGGAACCTGTGAA	0.363000										HNSCC(52;0.14)			6	9					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80667094	80667094	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:80667094G>A	ENST00000299564.8	-	3	811	c.656C>T	c.(655-657)cCa>cTa	p.P219L	CDYL2_ENST00000563890.1_Missense_Mutation_p.P220L|CDYL2_ENST00000566173.1_Missense_Mutation_p.P220L|CDYL2_ENST00000562812.1_Missense_Mutation_p.P220L	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	219						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						CCTCTTCACTGGACTGTGCAG	0.483000													35	109					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43258539	43258539	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43258539G>A	ENST00000404209.4	-	5	1285	c.1189C>T	c.(1189-1191)Cgt>Tgt	p.R397C	PSG8_ENST00000406636.3_Missense_Mutation_p.R275C|PSG8_ENST00000401467.2_Missense_Mutation_p.R304C|PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000306511.4_Missense_Mutation_p.R397C	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	397	Ig-like C2-type 3.					extracellular region		p.R397C(2)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GCTGAGTTACGAACAGAGCAA	0.448000													39	655					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38482250	38482250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38482250C>T	ENST00000263409.4	-	20	2903	c.2741G>A	c.(2740-2742)cGa>cAa	p.R914Q	LIFR_ENST00000453190.2_Missense_Mutation_p.R914Q	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	914					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					AAATGCTGATCGAGTTTCCAG	0.388000			T	PLAG1	salivary adenoma								44	93					0	0	1	0	0
ANO6	196527	broad.mit.edu	37	12	45742408	45742408	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:45742408C>T	ENST00000320560.8	+	6	943	c.741C>T	c.(739-741)ctC>ctT	p.L247L	ANO6_ENST00000425752.2_Silent_p.L247L|ANO6_ENST00000435642.1_Silent_p.L247L|ANO6_ENST00000426898.2_3'UTR|ANO6_ENST00000423947.3_Silent_p.L268L|ANO6_ENST00000441606.2_Silent_p.L229L	NM_001025356.2	NP_001020527.2	Q4KMQ2	ANO6_HUMAN	anoctamin 6	247					activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						CTTTCCCACTCCATGATGTAA	0.403000													13	72					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176128	140176128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140176128G>A	ENST00000526136.1	+	1	1579	c.1579G>A	c.(1579-1581)Gaa>Aaa	p.E527K	PCDHA2_ENST00000378132.1_Missense_Mutation_p.E527K|PCDHA2_ENST00000520672.2_Missense_Mutation_p.E527K|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCACGAGGAAGTGGAGCT	0.687000													47	122					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109793637	109793637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:109793637C>T	ENST00000356711.2	+	32	5137	c.5011C>T	c.(5011-5013)Ccc>Tcc	p.P1671S	MYO16_ENST00000357550.2_Missense_Mutation_p.P1671S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1671	Pro-rich.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TCTCAGCAGCCCCCTGGACGA	0.672000													7	16					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169412861	169412861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169412861C>T	ENST00000256935.8	+	29	3008	c.2928C>T	c.(2926-2928)ttC>ttT	p.F976F	DOCK2_ENST00000520908.1_Silent_p.F468F|DOCK2_ENST00000540750.1_Silent_p.F37F|DOCK2_ENST00000523351.1_3'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	976	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATCATGTTCAAGGACCTCA	0.468000													50	140					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24503662	24503662	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:24503662G>A	ENST00000357578.3	+	3	754		c.e3+1		ALDH5A1_ENST00000348925.2_Splice_Site|ALDH5A1_ENST00000491546.1_Splice_Site|ALDH5A1_ENST00000546278.1_Splice_Site	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1						acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	CATCACCCCGGTAGGTGACAG	0.562000													17	40					0	0	1	0	0
NPHP1	4867	broad.mit.edu	37	2	110902115	110902115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:110902115G>A	ENST00000316534.4	-	15	1625	c.1552C>T	c.(1552-1554)Cct>Tct	p.P518S	NPHP1_ENST00000417665.1_Missense_Mutation_p.P461S|NPHP1_ENST00000393272.3_Missense_Mutation_p.P517S|NPHP1_ENST00000355301.4_Missense_Mutation_p.P399S|NPHP1_ENST00000445609.2_Missense_Mutation_p.P462S			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	517					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						TTTTCATAAGGAGTACCACCA	0.358000													33	70					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219892338	219892338	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219892338C>T	ENST00000409865.3	-	13	2215	c.2212G>A	c.(2212-2214)Gtc>Atc	p.V738I	CCDC108_ENST00000441968.1_Intron|CCDC108_ENST00000410037.1_Missense_Mutation_p.V684I|CCDC108_ENST00000453220.1_Intron|CCDC108_ENST00000341552.5_Intron	NM_001278295.1	NP_001265224.1	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	0						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTAGCAGAGACCCCGCATTCC	0.607000													31	79					0	0	1	0	0
ACTG1P17	283693	broad.mit.edu	37	15	83395078	83395078	+	RNA	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83395078A>G	ENST00000560958.1	-	0	1208					NR_036446.1																						TTTGCGGTGAACAGTGGAGGG	0.502000													9	33					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34006106	34006106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34006106G>A	ENST00000297161.2	+	5	709	c.335G>A	c.(334-336)gGa>gAa	p.G112E	BMPER_ENST00000426693.1_Missense_Mutation_p.G112E	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	112	VWFC 2.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						ACCTATGAAGGAAATACCTAT	0.438000													13	48					0	0	1	0	0
MMP13	4322	broad.mit.edu	37	11	102824912	102824912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102824912C>T	ENST00000260302.3	-	4	638	c.610G>A	c.(610-612)Gat>Aat	p.D204N	MMP13_ENST00000340273.4_Missense_Mutation_p.D204N	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	204					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		CAGGTTTCATCATCATCAAAA	0.408000													7	53					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	88249327	88249327	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:88249327C>T	ENST00000518476.1	+	6	809	c.758C>T	c.(757-759)tCa>tTa	p.S253L	CNBD1_ENST00000522427.1_3'UTR	NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	253										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						TACCTACCTTCATATGACTCA	0.383000													19	40					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154124377	154124377	+	Missense_Mutation	SNP	C	C	T	rs137852366		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:154124377C>T	ENST00000360256.4	-	22	6604	c.6404G>A	c.(6403-6405)cGa>cAa	p.R2135Q		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2135	F5/8 type C 1.		R -> P (in HEMA; severe).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGAATTTCCTCGATAAGTCTG	0.408000													24	113					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15497228	15497228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:15497228C>T	ENST00000341776.2	+	7	2016	c.1772C>T	c.(1771-1773)cCc>cTc	p.P591L	JARID2_ENST00000397311.3_Missense_Mutation_p.P419L|JARID2_ENST00000541660.1_Missense_Mutation_p.P553L	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	591	JmjN.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGGGTGATCCCCCCTCCGGAC	0.642000													4	26					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31391694	31391694	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31391694C>T	ENST00000268296.4	+	27	3289	c.3168C>T	c.(3166-3168)gtC>gtT	p.V1056V	ITGAX_ENST00000562522.1_Silent_p.V1056V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	1056					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TTGGCTGGGTCCGCCAGGTGT	0.647000													6	19					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158589027	158589027	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158589027C>T	ENST00000368148.3	-	45	6695	c.6515G>A	c.(6514-6516)tGg>tAg	p.W2172*	SPTA1_ENST00000368147.3_Nonsense_Mutation_p.W2169*	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2172					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTCCAGGATCCATTGAAGGAA	0.483000													63	133					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38766682	38766682	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38766682G>A	ENST00000449082.2	-	17	3210	c.3211C>T	c.(3211-3213)Cct>Tct	p.P1071S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1071					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGGACCTGAGGAACAGACTCA	0.607000													21	42					0	0	1	0	0
NT5DC3	51559	broad.mit.edu	37	12	104190698	104190698	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104190698G>A	ENST00000392876.3	-	6	767	c.727C>T	c.(727-729)Cct>Tct	p.P243S	NT5DC3_ENST00000465502.1_5'UTR	NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	243							hydrolase activity|metal ion binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						AGATGCACAGGCTCATAGTCG	0.468000													26	134					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068408	5068408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5068408C>T	ENST00000380370.1	+	1	653	c.653C>T	c.(652-654)tCg>tTg	p.S218L		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	218					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTGGCATCTCGTATGTTTAC	0.453000													66	162					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25264389	25264389	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25264389G>A	ENST00000400358.4	+	11	1098	c.1041G>A	c.(1039-1041)caG>caA	p.Q347Q	SGSM1_ENST00000400359.4_Silent_p.Q347Q	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	347	Required for interaction with RAP family members.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						ACGGGATCCAGAGGCCGCCCT	0.642000													24	53					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107022146	107022146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:107022146G>A	ENST00000369701.3	+	26	3728	c.3501G>A	c.(3499-3501)atG>atA	p.M1167I		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1167						integral to membrane	neuropeptide receptor activity	p.M1167I(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGCAGGAGATGATTGGGTCAG	0.498000													27	59					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41694356	41694356	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:41694356C>T	ENST00000313860.7	+	26	3235	c.3181C>T	c.(3181-3183)Cga>Tga	p.R1061*	LIMCH1_ENST00000381753.4_Nonsense_Mutation_p.R868*|LIMCH1_ENST00000513024.1_Nonsense_Mutation_p.R888*|LIMCH1_ENST00000508501.1_Nonsense_Mutation_p.R1034*|LIMCH1_ENST00000512946.1_Nonsense_Mutation_p.R1035*|LIMCH1_ENST00000509277.1_Nonsense_Mutation_p.R894*|LIMCH1_ENST00000511496.1_Nonsense_Mutation_p.R875*|LIMCH1_ENST00000512820.1_Nonsense_Mutation_p.R1047*|LIMCH1_ENST00000503057.1_Nonsense_Mutation_p.R1445*|RP11-227F19.5_ENST00000506475.1_RNA|LIMCH1_ENST00000512632.1_Nonsense_Mutation_p.R958*|LIMCH1_ENST00000514096.1_Nonsense_Mutation_p.R875*|LIMCH1_ENST00000396595.3_Nonsense_Mutation_p.R880*	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	1061	LIM zinc-binding.				actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TGTTAGGATTCGAAATGGTCT	0.428000													13	68					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23409421	23409421	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23409421G>A	ENST00000307149.5	-	14	2018	c.1833C>T	c.(1831-1833)acC>acT	p.T611T		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	611					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		CATCTGTGAGGGTTTCTCCGA	0.532000													14	37					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38317410	38317410	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38317410C>T	ENST00000311856.4	+	7	1109	c.1060C>T	c.(1060-1062)Caa>Taa	p.Q354*	SLC22A13_ENST00000450935.2_3'UTR	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	354						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		CCTGAGCCTCCAAGTGGGGGA	0.572000													19	48					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140532154	140532154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140532154C>T	ENST00000231136.1	+	1	2316	c.2316C>T	c.(2314-2316)ttC>ttT	p.F772F	PCDHB6_ENST00000543635.1_Silent_p.F636F	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		772					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCCCAACTTCCCTCCTCAGG	0.483000													26	96					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91780176	91780176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91780176C>T	ENST00000389857.6	-	15	2070	c.1984G>A	c.(1984-1986)Gag>Aag	p.E662K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	662					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TCCAGGGCCTCGACTTTCTCG	0.632000													5	22					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38760200	38760200	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38760200C>T	ENST00000449082.2	-	20	3624	c.3625G>A	c.(3625-3627)Ggc>Agc	p.G1209S		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1209					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTTTTGAAGCCATAGGCCACC	0.527000													30	96					0	0	1	0	0
C4B	721	broad.mit.edu	37	6	31997527	31997527	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31997527C>T	ENST00000435363.2	+	29	3945	c.3861C>T	c.(3859-3861)gcC>gcT	p.A1287A	C4B_ENST00000425700.2_Silent_p.A1287A	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1287					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										AGGCTGCGGCCTGGCTCACCC	0.667000													24	96					0	0	1	0	0
OR5D14	219436	broad.mit.edu	37	11	55563286	55563286	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55563286G>A	ENST00000335605.1	+	1	255	c.255G>A	c.(253-255)gaG>gaA	p.E85E		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				AGCTGCTTGAGAACTTGGTAA	0.423000													18	68					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32567576	32567576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:32567576G>A	ENST00000286827.3	-	14	3010	c.2539C>T	c.(2539-2541)Cac>Tac	p.H847Y	TIAM1_ENST00000541036.1_Missense_Mutation_p.H787Y	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	847	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity	p.H847Y(1)		autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TTCTCAATGTGGATGCTCTGA	0.303000													14	53					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20422911	20422911	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20422911C>T	ENST00000331849.4	+	2	252	c.105C>T	c.(103-105)atC>atT	p.I35I	ACSM5_ENST00000575584.1_Silent_p.I35I	NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	35					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						CTCAGAAGATCGTGGCCACCT	0.582000													15	37					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135561040	135561040	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:135561040C>T	ENST00000513104.1	-	10	2547	c.2265G>A	c.(2263-2265)aaG>aaA	p.K755K	TRPC7_ENST00000355180.3_Silent_p.K694K|TRPC7_ENST00000426057.2_Silent_p.K639K	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	755					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTAGCGAGTCTTCTGGATAA	0.453000													4	18					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36370056	36370056	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36370056C>T	ENST00000221891.4	+	16	1986	c.1794C>T	c.(1792-1794)gtC>gtT	p.V598V	APLP1_ENST00000586861.1_Silent_p.V591V|APLP1_ENST00000537454.2_Silent_p.V558V	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	597					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCTCATCGTCCTCTCCATGC	0.642000													27	46					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55175707	55175707	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55175707G>A	ENST00000421030.2	+	24	4104	c.3819G>A	c.(3817-3819)caG>caA	p.Q1273Q	MROH7_ENST00000454855.2_Silent_p.Q791Q|MROH7_ENST00000409996.1_Silent_p.Q841Q|MROH7_ENST00000414150.2_Intron	NM_001039464.2	NP_001034553.2			maestro heat-like repeat family member 7																		GCTGCTGGCAGAACTCCTGGC	0.617000													6	62					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57863320	57863320	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57863320G>A	ENST00000228682.2	+	11	1506	c.1415G>A	c.(1414-1416)gGg>gAg	p.G472E	GLI1_ENST00000543426.1_Missense_Mutation_p.G344E|GLI1_ENST00000546141.1_Missense_Mutation_p.G431E	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	472					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			GGCAATGCAGGGGGCAGCACT	0.612000													23	87					0	0	1	0	0
RNF6	6049	broad.mit.edu	37	13	26789453	26789453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:26789453G>A	ENST00000381588.4	-	5	1318	c.566C>T	c.(565-567)tCa>tTa	p.S189L	RNF6_ENST00000399762.2_Intron|RNF6_ENST00000346166.3_Missense_Mutation_p.S189L|RNF6_ENST00000468480.1_Intron|RNF6_ENST00000381570.3_Missense_Mutation_p.S189L	NM_005977.3	NP_005968.1	Q9Y252	RNF6_HUMAN	ring finger protein (C3H2C3 type) 6	189					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(3)|ovary(2)|prostate(2)|skin(2)	23	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		AGGACTAGTTGACCTTTGTTG	0.403000													18	275					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179644044	179644044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179644044C>T	ENST00000589042.1	-	23	4099	c.3875G>A	c.(3874-3876)gGa>gAa	p.G1292E	TTN_ENST00000342992.6_Missense_Mutation_p.G1292E|TTN_ENST00000360870.5_Missense_Mutation_p.G1292E|TTN_ENST00000460472.2_Missense_Mutation_p.G1246E|TTN_ENST00000342175.6_Missense_Mutation_p.G1246E|TTN_ENST00000359218.5_Missense_Mutation_p.G1246E|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G1292E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1292	Ig-like 5.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAATCAAATCCTGATTCAAC	0.328000													12	54					0	0	1	0	0
COLEC10	10584	broad.mit.edu	37	8	120101930	120101930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:120101930G>A	ENST00000332843.2	+	2	201	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	COLEC10_ENST00000521788.1_3'UTR	NM_006438.3	NP_006429.2	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 (C-type lectin)	54	Collagen-like.					collagen|cytoplasm	mannose binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			AGATGATGGTGAAAAAGGAGA	0.413000													15	37					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47593172	47593172	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47593172G>A	ENST00000273859.3	+	23	4324	c.4055G>A	c.(4054-4056)gGg>gAg	p.G1352E		NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1352					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						AAGTGGAGAGGGGCTGGAAAG	0.473000													24	91					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43237428	43237428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43237428C>T	ENST00000304139.5	+	13	2043	c.1881C>T	c.(1879-1881)ccC>ccT	p.P627P	TTBK1_ENST00000259750.4_Intron			Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	680						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGTACAGCCCCCTGCGACGAC	0.652000													16	26					0	0	1	0	0
CNNM1	26507	broad.mit.edu	37	10	101147941	101147941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101147941G>A	ENST00000356713.4	+	9	2846	c.2557G>A	c.(2557-2559)Gag>Aag	p.E853K	CNNM1_ENST00000370528.3_Intron|CNNM1_ENST00000446890.1_Missense_Mutation_p.E782K|CNNM1_ENST00000370534.4_Missense_Mutation_p.E509K	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	853					ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		AAGCCCCAGCGAGGTAGTGTA	0.607000													16	59					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98744436	98744436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98744436C>T	ENST00000286067.2	+	1	3396	c.3289C>T	c.(3289-3291)Cct>Tct	p.P1097S		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	1097										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AGGCAGCAGCCCTCCAGATAG	0.512000													9	58					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42168793	42168793	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42168793C>T	ENST00000444063.1	+	17	2038	c.1906C>T	c.(1906-1908)Ctc>Ttc	p.L636F	L3MBTL1_ENST00000373134.1_Missense_Mutation_p.L641F|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.L704F|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.L636F|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.L704F			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	636					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						CTTTCCAGCCCTCACGCCCGA	0.612000													12	49					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45478136	45478136	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:45478136C>T	ENST00000361462.2	+	6	3108	c.2925C>T	c.(2923-2925)tcC>tcT	p.S975S	FAM179B_ENST00000382233.2_Intron|KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Silent_p.S975S			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	975	Ser-rich.						binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						CTCTTAGGTCCCTTCGTAATA	0.348000													27	74					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117106777	117106777	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117106777C>T	ENST00000262820.3	-	1	924	c.15G>A	c.(13-15)tgG>tgA	p.W5*	KLHL13_ENST00000371882.1_Intron|KLHL13_ENST00000539496.1_Intron|KLHL13_ENST00000540167.1_Intron|KLHL13_ENST00000545703.1_Intron|KLHL13_ENST00000541812.1_Intron|KLHL13_ENST00000371878.1_Intron|KLHL13_ENST00000469946.1_Intron	NM_033495.3	NP_277030.2	Q9P2N7	KLH13_HUMAN	kelch-like family member 13	5					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						AGCTCGTTTTCCATTTCAATG	0.418000													27	18					0	0	1	0	0
KCNK9	51305	broad.mit.edu	37	8	140630507	140630507	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:140630507G>A	ENST00000520439.1	-	2	1182	c.1119C>T	c.(1117-1119)tcC>tcT	p.S373S	KCNK9_ENST00000303015.1_Silent_p.S373S			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	373						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			ACACCTAAACGGACTTCCGGC	0.433000													30	162					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197403941	197403941	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197403941G>A	ENST00000367397.1	+	5	1949	c.1091G>A	c.(1090-1092)aGg>aAg	p.R364K	CRB1_ENST00000535699.1_Missense_Mutation_p.R959K|CRB1_ENST00000367400.3_Missense_Mutation_p.R983K|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000544212.1_Missense_Mutation_p.R464K|CRB1_ENST00000367399.2_Missense_Mutation_p.R871K			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	983	EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TTCAGAACAAGGGATGCAAAT	0.338000													21	107					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110831287	110831287	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110831287C>T	ENST00000375820.4	-	31	2562	c.2441G>A	c.(2440-2442)gGa>gAa	p.G814E		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	814	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCCCGGTGGTCCCTGTCCTCC	0.587000													8	13					0	0	1	0	0
CPLX3	594855	broad.mit.edu	37	15	75122542	75122542	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75122542G>A	ENST00000395018.4	+	3	481	c.324G>A	c.(322-324)atG>atA	p.M108I	RP11-414J4.2_ENST00000564823.1_RNA	NM_001030005.2	NP_001025176.1	Q8WVH0	CPLX3_HUMAN	complexin 3	108						cell junction|synapse	syntaxin binding			large_intestine(2)|lung(2)	4						TGGCCAAGATGATCGAGGAGG	0.622000													19	95					0	0	1	0	0
IGLV5-48	28780	broad.mit.edu	37	22	22707693	22707693	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22707693C>T	ENST00000390293.1	+	0	281																											AAAGATGCTTCGAGCAATGCA	0.517000													45	100					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64225436	64225436	+	Missense_Mutation	SNP	C	C	T	rs149659675	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:64225436C>T	ENST00000205948.6	-	1	99	c.62G>A	c.(61-63)cGg>cAg	p.R21Q		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	21	Sushi 1.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			GTACTTACTCCGTCCTGCAAT	0.418000													8	34					0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53911378	53911378	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53911378G>A	ENST00000335754.3	-	5	647	c.547C>T	c.(547-549)Cac>Tac	p.H183Y	ACTR8_ENST00000482349.1_Missense_Mutation_p.H72Y	NM_022899.4	NP_075050.3	Q9H981	ARP8_HUMAN	ARP8 actin-related protein 8 homolog (yeast)	183					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		ATAGGCCAGTGAATATTGTAA	0.423000													24	61					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39553606	39553606	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39553606G>A	ENST00000251645.2	-	1	238	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	62	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				GGTCGTTCAGGAACTGCATAG	0.622000													52	83					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201182696	201182696	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201182696G>A	ENST00000335211.4	+	12	8805	c.8675G>A	c.(8674-8676)aGt>aAt	p.S2892N	IGFN1_ENST00000451870.2_Missense_Mutation_p.S435N|IGFN1_ENST00000295591.8_Missense_Mutation_p.S52N	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCTACCCGGAGTTCCACATCC	0.572000													22	68					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150490215	150490215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150490215C>T	ENST00000447204.2	-	5	933	c.561G>A	c.(559-561)tgG>tgA	p.W187*	TMEM176B_ENST00000450753.2_Nonsense_Mutation_p.W150*|TMEM176B_ENST00000492607.1_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000429904.2_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000326442.5_Nonsense_Mutation_p.W187*|TMEM176B_ENST00000434545.1_Nonsense_Mutation_p.W187*	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	187					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCCTTCTGCCATTGGTTCT	0.527000													15	92					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170063345	170063345	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170063345C>T	ENST00000263816.3	-	39	7170	c.6885G>A	c.(6883-6885)agG>agA	p.R2295R		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2295					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTTTCAAATTCCTATCTACCC	0.413000													37	74					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87180118	87180118	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87180118C>T	ENST00000265724.3	-	11	1453	c.1036G>A	c.(1036-1038)Gga>Aga	p.G346R	ABCB1_ENST00000543898.1_Missense_Mutation_p.G282R	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	346	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GATGCCTGTCCAACACTAAAA	0.368000													31	58					0	0	1	0	0
SPRY3	10251	broad.mit.edu	37	X	155004272	155004272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:155004272C>T	ENST00000302805.2	+	2	1170	c.739C>T	c.(739-741)Ctg>Ttg	p.L247L		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	247	Cys-rich.|SPR.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane						all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATGCCTCCATCTGTGCCAACA	0.587000													82	170					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177317	89177317	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:89177317C>T	ENST00000561129.2	+	1	363	c.233C>T	c.(232-234)cCt>cTt	p.P78L	TGIF2LX_ENST00000283891.5_Missense_Mutation_p.P78L			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	78						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						AAGGCCTACCCTTCAGAAGAA	0.478000													72	37					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86370307	86370307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:86370307G>A	ENST00000400286.2	-	2	935	c.337C>T	c.(337-339)Ctc>Ttc	p.L113F		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	113						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TGTTTCAGGAGGCCAAGGCCA	0.363000													50	89					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134968304	134968304	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:134968304C>T	ENST00000398015.3	+	15	3187	c.2817C>T	c.(2815-2817)tcC>tcT	p.S939S	EPHB1_ENST00000493838.1_Silent_p.S500S	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	939	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GCTTCACCTCCCTCCAGCTGG	0.552000													23	78					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26527408	26527408	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26527408G>A	ENST00000456354.2	+	8	1142	c.1075G>A	c.(1075-1077)Gaa>Aaa	p.E359K		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	359					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCCTCCAGGAACCCCTTGC	0.577000													19	70					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220326713	220326713	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220326713G>A	ENST00000312358.7	+	7	2682	c.2550G>A	c.(2548-2550)atG>atA	p.M850I	SPEG_ENST00000396698.1_Missense_Mutation_p.M746I|SPEG_ENST00000396686.1_Start_Codon_SNP_p.M1I|SPEG_ENST00000396688.1_Start_Codon_SNP_p.M1I|SPEG_ENST00000396689.2_Start_Codon_SNP_p.M1I|SPEG_ENST00000396695.2_Missense_Mutation_p.M58I|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	850					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCCCACCATGAAGCCCAGTC	0.647000													40	100					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18863935	18863935	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:18863935C>T	ENST00000317977.6	+	5	826	c.255C>T	c.(253-255)tcC>tcT	p.S85S	SLC5A10_ENST00000395645.3_Silent_p.S141S|SLC5A10_ENST00000395642.1_Silent_p.S85S|SLC5A10_ENST00000395647.2_Silent_p.S141S|SLC5A10_ENST00000417251.2_Silent_p.S141S|SLC5A10_ENST00000395643.2_Silent_p.S141S			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	141					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						CTGTCCTGTCCCTGCTACTGT	0.587000											OREG0024231	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	57					0	0	1	0	0
SV2C	22987	broad.mit.edu	37	5	75597272	75597272	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75597272C>T	ENST00000502798.2	+	12	2344	c.1902C>T	c.(1900-1902)tcC>tcT	p.S634S	RP11-466P24.6_ENST00000502589.1_RNA|SV2C_ENST00000322285.7_Silent_p.S634S	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	634					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CCAGTGAATCCATGATGATAG	0.507000													40	184					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103124631	103124631	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103124631G>A	ENST00000295269.4	+	5	1749	c.1292G>A	c.(1291-1293)gGa>gAa	p.G431E		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	431					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GGTGTTCGAGGAGCTGGAAGT	0.398000													30	91					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43552318	43552318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43552318G>A	ENST00000220420.5	-	3	375	c.368C>T	c.(367-369)tCc>tTc	p.S123F	TGM5_ENST00000349114.4_Intron	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	123					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CCCCTGGAAGGAGTCGATGTG	0.627000													22	107					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699232	43699232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43699232C>T	ENST00000405312.3	-	4	1140	c.903G>A	c.(901-903)acG>acA	p.T301T	PSG4_ENST00000433626.2_Silent_p.T208T|PSG4_ENST00000244295.9_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	301	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region		p.T301T(1)		central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				TTTCATTTCTCGTGACATTGG	0.478000													35	301					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39019623	39019623	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39019623G>A	ENST00000355481.4	+	75	11183	c.11052G>A	c.(11050-11052)gaG>gaA	p.E3684E	RYR1_ENST00000360985.3_Silent_p.E3689E|RYR1_ENST00000359596.3_Silent_p.E3689E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3689					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	aggaggaagaggtggaagaga	0.612000													7	11					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37415610	37415610	+	Silent	SNP	G	G	A	rs140600686	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:37415610G>A	ENST00000535679.1	-	1	173	c.174C>T	c.(172-174)atC>atT	p.I58I	SULT6B1_ENST00000379149.2_Silent_p.I58I|SULT6B1_ENST00000260637.3_Silent_p.I20I|SULT6B1_ENST00000407963.1_Silent_p.I20I			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	58						cytoplasm	sulfotransferase activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				ATGCTAGCACGATGTCATCAT	0.463000													21	110					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813799	123813799	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123813799G>A	ENST00000321252.2	-	1	781	c.747C>T	c.(745-747)gtC>gtT	p.V249V		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CATAGATGATGACCACCACTG	0.512000													31	87					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18320445	18320445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18320445G>A	ENST00000396253.3	-	9	1178	c.716C>T	c.(715-717)tCc>tTc	p.S239F	HPS5_ENST00000531848.1_Missense_Mutation_p.S239F|HPS5_ENST00000438420.2_Missense_Mutation_p.S239F|HPS5_ENST00000349215.3_Missense_Mutation_p.S353F	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	353						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						AGATATCAGGGAGAGATGTGA	0.458000									Hermansky-Pudlak syndrome				34	98					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49357515	49357515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49357515G>A	ENST00000263265.6	-	10	1609	c.1054C>T	c.(1054-1056)Cct>Tct	p.P352S	PLEKHA4_ENST00000355496.5_Missense_Mutation_p.P327S	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	352	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		TCCAGGGGAGGACCCGGCTGA	0.498000													46	97					0	0	1	0	0
SULT1A1	6817	broad.mit.edu	37	16	28620128	28620128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28620128C>T	ENST00000395609.1	-	4	807	c.49G>A	c.(49-51)Ggg>Agg	p.G17R	SULT1A1_ENST00000569554.1_Missense_Mutation_p.G17R|SULT1A1_ENST00000314752.7_Missense_Mutation_p.G17R|SULT1A1_ENST00000350842.4_Intron|SULT1A1_ENST00000395607.1_Missense_Mutation_p.G17R			P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1	17					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			endometrium(2)|kidney(7)|large_intestine(2)|lung(2)|ovary(1)|stomach(2)	16						AGCGGGACCCCCTTCACGTAC	0.637000													11	78					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087069	92087069	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92087069C>T	ENST00000298047.6	+	1	1808	c.1791C>T	c.(1789-1791)atC>atT	p.I597I	FAT3_ENST00000541502.1_Silent_p.I597I|FAT3_ENST00000409404.2_Silent_p.I597I|FAT3_ENST00000525166.1_Silent_p.I447I			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	597	Cadherin 6.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GTGGTCACATCACAGCAGTCT	0.393000										TCGA Ovarian(4;0.039)			16	32					0	0	1	0	0
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5664531	5664531	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5664531G>A	ENST00000354852.5	+	14	2294	c.2121G>A	c.(2119-2121)gtG>gtA	p.V707V	HBG2_ENST00000380259.2_Intron|TRIM34_ENST00000495668.1_3'UTR|TRIM34_ENST00000514226.1_Silent_p.V353V|TRIM34_ENST00000429814.2_Silent_p.V353V|TRIM6-TRIM34_ENST00000457787.2_Silent_p.V353V	NM_001003819.3	NP_001003819.1	B2RNG4	B2RNG4_HUMAN		707						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(9)|ovary(1)|prostate(2)|stomach(2)|urinary_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		ACTGGGAAGTGGACGTGTCCA	0.418000													18	51					0	0	1	0	0
C1orf65	164127	broad.mit.edu	37	1	223567374	223567374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:223567374C>T	ENST00000366875.3	+	1	660	c.557C>T	c.(556-558)tCc>tTc	p.S186F		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	186										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		TGGTCCCCTTCCTCAGTTCCC	0.607000													29	53					0	0	1	0	0
C2orf42	54980	broad.mit.edu	37	2	70402845	70402845	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70402845G>A	ENST00000264434.2	-	5	1378	c.999C>T	c.(997-999)ggC>ggT	p.G333G	C2orf42_ENST00000420306.1_Silent_p.G333G	NM_017880.1	NP_060350.1	Q9NWW7	CB042_HUMAN	chromosome 2 open reading frame 42	333										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						GCTTTTTCAGGCCACTTTTCC	0.433000													96	254					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187618	123187618	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123187618C>T	ENST00000328880.5	-	1	272	c.213G>A	c.(211-213)gtG>gtA	p.V71V	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	71					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	GAAAGTCAGCCACTGCCAGGT	0.527000													21	41					0	0	1	0	0
ANKRD2	26287	broad.mit.edu	37	10	99343372	99343372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99343372G>A	ENST00000307518.5	+	9	1240	c.973G>A	c.(973-975)Gct>Act	p.A325T	ANKRD2_ENST00000298808.5_Missense_Mutation_p.A292T|ANKRD2_ENST00000455090.1_Missense_Mutation_p.A265T|ANKRD2_ENST00000370655.1_Missense_Mutation_p.A298T			Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 (stretch responsive muscle)	325					muscle contraction|muscle organ development		structural constituent of muscle			breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		GCTCTGGCAGGCTGATACCCG	0.647000													8	14					0	0	1	0	0
ACSBG2	81616	broad.mit.edu	37	19	6187365	6187365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6187365C>T	ENST00000588304.1	+	12	1908	c.1462C>T	c.(1462-1464)Ccc>Tcc	p.P488S	ACSBG2_ENST00000586696.1_Missense_Mutation_p.P538S|ACSBG2_ENST00000591741.1_3'UTR|ACSBG2_ENST00000252669.5_Missense_Mutation_p.P538S|ACSBG2_ENST00000591403.1_Missense_Mutation_p.P538S|ACSBG2_ENST00000588485.1_Missense_Mutation_p.P351S			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	538					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAAGAAGATCCCCATCATCAG	0.468000													45	114					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477498	128477498	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128477498G>A	ENST00000322313.4	-	16	2259	c.2101C>T	c.(2101-2103)Cct>Tct	p.P701S		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	701	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TGACCTTGAGGACCAGAACTA	0.642000													15	81					0	0	1	0	0
SLC22A20	440044	broad.mit.edu	37	11	64981483	64981483	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64981483C>T	ENST00000525437.1	+	0	173							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						GCCGCTGTCCCCCCCCACCAC	0.692000													5	12					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3639790	3639790	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3639790G>A	ENST00000294008.3	-	12	4489	c.3849C>T	c.(3847-3849)gcC>gcT	p.A1283A		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1283	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CCGCCTGCACGGCCAGCCCGC	0.632000								Direct reversal of damage					41	81					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121932424	121932424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:121932424G>A	ENST00000377069.4	-	12	2005	c.1599C>T	c.(1597-1599)atC>atT	p.I533I	KDM2B_ENST00000377071.4_Silent_p.I564I|KDM2B_ENST00000536437.1_Silent_p.I447I|KDM2B_ENST00000542973.1_5'UTR|KDM2B_ENST00000538046.2_Silent_p.I474I	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	564					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GGACCCCAGTGATGGCCAGAC	0.587000											OREG0022202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	29					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635402	33635402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:33635402C>T	ENST00000380099.3	+	4	2194	c.2186C>T	c.(2185-2187)gCc>gTc	p.A729V	KL_ENST00000426690.2_3'UTR|KL_ENST00000487852.1_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	729	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ATATCCATAGCCTTGCAGGCT	0.493000													6	62					0	0	1	0	0
SBK1	388228	broad.mit.edu	37	16	28328886	28328886	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:28328886G>A	ENST00000341901.4	+	2	963	c.174G>A	c.(172-174)gaG>gaA	p.E58E		NM_001024401.2	NP_001019572.1	Q52WX2	SBK1_HUMAN	SH3 domain binding kinase 1	58	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			kidney(1)|lung(3)|ovary(1)	5						TAGTCCGGGAGCTGGGCAAAG	0.627000											OREG0023701	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	55					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152507129	152507129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152507129C>T	ENST00000427231.2	-	53	7388	c.7186G>A	c.(7186-7188)Gat>Aat	p.D2396N	NEB_ENST00000409198.1_Missense_Mutation_p.D2396N|NEB_ENST00000397345.3_Missense_Mutation_p.D2396N|NEB_ENST00000604864.1_Missense_Mutation_p.D2396N|NEB_ENST00000172853.10_Missense_Mutation_p.D2396N|NEB_ENST00000603639.1_Missense_Mutation_p.D2396N	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2396					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGCACAACATCGTTCTGATCA	0.388000													67	172					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36778896	36778896	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36778896C>T	ENST00000416516.2	-	2	1745	c.1255G>A	c.(1255-1257)Gaa>Aaa	p.E419K		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	419	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						TCGTAGACTTCATGCAATTTC	0.493000													15	59					0	0	1	0	0
COMP	1311	broad.mit.edu	37	19	18893760	18893760	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18893760C>T	ENST00000542601.2	-	18	2529	c.2140G>A	c.(2140-2142)Gag>Aag	p.E714K	COMP_ENST00000222271.2_Missense_Mutation_p.E747K|COMP_ENST00000425807.1_Missense_Mutation_p.E694K			P49747	COMP_HUMAN	cartilage oligomeric matrix protein	747	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding			breast(6)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						TCATAGTCCTCTGGGATGGTG	0.697000													19	83					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153054170	153054170	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153054170G>A	ENST00000285900.5	+	6	1153	c.810G>A	c.(808-810)tgG>tgA	p.W270*	GRIA1_ENST00000518783.1_Nonsense_Mutation_p.W280*|GRIA1_ENST00000521843.2_Nonsense_Mutation_p.W201*|GRIA1_ENST00000340592.5_Nonsense_Mutation_p.W270*|GRIA1_ENST00000448073.4_Nonsense_Mutation_p.W280*|GRIA1_ENST00000518142.1_Nonsense_Mutation_p.W190*	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	270					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGCAGCAGTGGAAGAATAGTG	0.532000													43	97					0	0	1	0	0
GEMIN5	25929	broad.mit.edu	37	5	154284151	154284151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154284151G>A	ENST00000285873.7	-	18	2623	c.2548C>T	c.(2548-2550)Ccc>Tcc	p.P850S		NM_001252156.1|NM_015465.4	NP_001239085.1|NP_056280.2	Q8TEQ6	GEMI5_HUMAN	gem (nuclear organelle) associated protein 5	850					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTACTCAGGGGAAGCAAGGAA	0.403000													34	81					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30992021	30992021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30992021G>A	ENST00000383096.3	-	3	214	c.32C>T	c.(31-33)tCc>tTc	p.S11F	CCDC178_ENST00000402325.1_Missense_Mutation_p.S11F|CCDC178_ENST00000583930.1_Missense_Mutation_p.S11F|CCDC178_ENST00000406524.2_Missense_Mutation_p.S11F|CCDC178_ENST00000579916.1_Missense_Mutation_p.S11F|CCDC178_ENST00000579947.1_Missense_Mutation_p.S11F|CCDC178_ENST00000403303.1_Missense_Mutation_p.S11F|CCDC178_ENST00000300227.8_Missense_Mutation_p.S11F					coiled-coil domain containing 178																		ATCTCTAGTGGAAGAAGAGGA	0.254000													15	48					0	0	1	0	0
TTC23	64927	broad.mit.edu	37	15	99759112	99759112	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:99759112G>A	ENST00000394132.2	-	7	1263	c.446C>T	c.(445-447)tCc>tTc	p.S149F	TTC23_ENST00000558613.1_Missense_Mutation_p.S149F|TTC23_ENST00000394129.2_Missense_Mutation_p.S149F|TTC23_ENST00000262074.4_Missense_Mutation_p.S149F|TTC23_ENST00000394130.1_Missense_Mutation_p.S149F|TTC23_ENST00000394136.1_Missense_Mutation_p.S149F|TTC23_ENST00000558663.1_Missense_Mutation_p.S149F|TTC23_ENST00000394135.3_Missense_Mutation_p.S149F			Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	149							binding			endometrium(2)|large_intestine(3)|lung(9)|urinary_tract(2)	16	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			CTTTTGAAGGGAGAGTAAAGC	0.393000													79	105					0	0	1	0	0
TTC39B	158219	broad.mit.edu	37	9	15185362	15185362	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:15185362G>A	ENST00000355694.2	-	16	1566	c.1332C>T	c.(1330-1332)atC>atT	p.I444I	TTC39B_ENST00000507285.1_Silent_p.I345I|TTC39B_ENST00000512701.1_Silent_p.I510I|TTC39B_ENST00000380850.4_Silent_p.I497I|TTC39B_ENST00000297615.5_Silent_p.I441I|TTC39B_ENST00000507993.1_Silent_p.I345I	NM_001168339.1|NM_152574.2	NP_001161811.1|NP_689787.2	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	444							binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)	21						TCTCAGTAGGGATAGATTTCC	0.502000													34	73					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60359415	60359415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60359415G>A	ENST00000371204.3	-	9	1460	c.1417C>T	c.(1417-1419)Ccc>Tcc	p.P473S	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	473					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					TTGTTTGGGGGCCTGAAGGTA	0.463000													121	309					0	0	1	0	0
CYP21A2	1589	broad.mit.edu	37	6	32008204	32008204	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32008204G>A	ENST00000418967.2	+	8	1119	c.961G>A	c.(961-963)Gag>Aag	p.E321K	CYP21A2_ENST00000435122.2_Missense_Mutation_p.E291K	NM_000500.7	NP_000491.4	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A, polypeptide 2	320					glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	11						ACTGCAGGAGGAGCTAGACCA	0.662000													13	38					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7623214	7623214	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7623214G>T	ENST00000572933.1	+	2	1622	c.162G>T	c.(160-162)gaG>gaT	p.E54D	DNAH2_ENST00000389173.2_Missense_Mutation_p.E54D|DNAH2_ENST00000082259.3_Missense_Mutation_p.E54D|DNAH2_ENST00000570791.1_Missense_Mutation_p.E54D			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	54	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCAAGGAGGAGCCTGGTGGGT	0.647000													5	6					3.59834e-05	3.60489e-05	1	1	0
NDUFS4	4724	broad.mit.edu	37	5	52978999	52978999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52978999C>T	ENST00000296684.5	+	5	504	c.476C>T	c.(475-477)tCt>tTt	p.S159F		NM_002495.2	NP_002486.1	O43181	NDUS4_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	159					brain development|cAMP-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|positive regulation of fibroblast proliferation|reactive oxygen species metabolic process|regulation of protein phosphorylation|response to cAMP|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(3)	10		Lung NSC(810;8.27e-05)|Breast(144;0.0848)			NADH(DB00157)	AAGTCCAAGTCTTATGGTGCA	0.393000													30	133					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65083039	65083039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:65083039G>A	ENST00000358691.5	-	32	5566	c.5400C>T	c.(5398-5400)tcC>tcT	p.S1800S	HELZ_ENST00000580168.1_Silent_p.S1801S	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGGACTCCGGGGATGAAAAGT	0.468000													52	112					0	0	1	0	0
INTS4P1	285905	broad.mit.edu	37	7	64639830	64639830	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:64639830C>T	ENST00000587624.1	+	0	713																											CTAACAACATCACCCTCCGAG	0.473000													14	96					0	0	1	0	0
TTC12	54970	broad.mit.edu	37	11	113234613	113234613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113234613C>T	ENST00000393020.1	+	20	2185	c.1780C>T	c.(1780-1782)Cat>Tat	p.H594Y	TTC12_ENST00000314756.3_Missense_Mutation_p.H594Y|TTC12_ENST00000483239.2_Missense_Mutation_p.H600Y|TTC12_ENST00000529221.1_Missense_Mutation_p.H594Y			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	594							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		GAATAGTTATCATGAAGCTCG	0.388000													18	46					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126004086	126004086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:126004086C>T	ENST00000299308.3	+	4	1201	c.1193C>T	c.(1192-1194)cCg>cTg	p.P398L		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	398						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTGGAGTACCCGATTGAGGAC	0.532000													21	80					0	0	1	0	0
LRRC4	64101	broad.mit.edu	37	7	127668746	127668746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127668746C>T	ENST00000249363.3	-	2	2205	c.1948G>A	c.(1948-1950)Gaa>Aaa	p.E650K	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	650						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		ATTTGAGTTTCCTGTACCTTG	0.438000													35	89					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127474324	127474324	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127474324C>T	ENST00000262461.2	+	8	1633	c.1444C>T	c.(1444-1446)Cga>Tga	p.R482*	SLC12A2_ENST00000343225.4_Nonsense_Mutation_p.R482*	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	482					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCCCGATTTTCGAGAGGAAGA	0.373000													21	129					0	0	1	0	0
VTCN1	79679	broad.mit.edu	37	1	117699466	117699466	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:117699466C>T	ENST00000369458.3	-	3	253	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	VTCN1_ENST00000463461.1_5'UTR|VTCN1_ENST00000539893.1_5'UTR|VTCN1_ENST00000328189.3_Intron|VTCN1_ENST00000359008.4_Missense_Mutation_p.E62K	NM_024626.3	NP_078902.2	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation inhibitor 1	59	Ig-like V-type 1.					integral to membrane|plasma membrane				large_intestine(7)|lung(4)|upper_aerodigestive_tract(1)	12	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		ATGTCAGGTTCAAAAGTGCAG	0.478000													22	81					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214805	161214805	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:161214805C>T	ENST00000327928.4	+	1	210	c.210C>T	c.(208-210)acC>acT	p.T70T		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	70						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AACCAATTACCAAACCCTCGG	0.458000													16	136					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870878	13870878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13870878C>T	ENST00000265104.4	-	24	3936	c.3832G>A	c.(3832-3834)Gag>Aag	p.E1278K	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1278	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTAGTTACCTCAATAGGTCCT	0.373000									Kartagener syndrome				12	54					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180365995	180365995	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:180365995C>T	ENST00000273654.4	-	16	2191	c.1572G>A	c.(1570-1572)ctG>ctA	p.L524L	CCDC39_ENST00000442201.2_Silent_p.L440L			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	440					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTTCAAAATCCAGTTTTTGTA	0.343000													13	46					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49557646	49557646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49557646G>A	ENST00000561648.1	-	7	3767	c.3714C>T	c.(3712-3714)ttC>ttT	p.F1238F	ZNF423_ENST00000567169.1_Silent_p.F1121F|ZNF423_ENST00000535559.1_Silent_p.F1121F|ZNF423_ENST00000563137.2_Silent_p.F1178F|ZNF423_ENST00000562520.1_Silent_p.F1178F|ZNF423_ENST00000262383.2_Silent_p.F1238F|ZNF423_ENST00000562871.1_Silent_p.F1178F	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1238					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TGGCCTGGACGAAGACTAGAC	0.587000													10	32					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24653942	24653942	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24653942G>A	ENST00000354464.6	-	16	1726	c.1550C>T	c.(1549-1551)cCc>cTc	p.P517L	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	517					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		AGGGAAGTAGGGCAGCAGCGA	0.612000													11	18					0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53515147	53515147	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53515147G>A	ENST00000301466.3	+	12	1258	c.1198G>A	c.(1198-1200)Gac>Aac	p.D400N		NM_003578.3	NP_003569.1	O75908	SOAT2_HUMAN	sterol O-acyltransferase 2	400					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						GGTGGTCCATGACTGGCTGTA	0.567000													7	72					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785631	22785631	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22785631G>A	ENST00000600260.1	+	0	1638					NR_033899.1																						CAGCGCTGAAGGAGCAGCACC	0.667000													10	17					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122536928	122536928	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:122536928G>A	ENST00000264357.5	+	8	1456	c.1164G>A	c.(1162-1164)atG>atA	p.M388I	GRIA3_ENST00000542149.1_Missense_Mutation_p.M388I|GRIA3_ENST00000541091.1_Missense_Mutation_p.M372I|GRIA3_ENST00000371256.5_Missense_Mutation_p.M388I|GRIA3_ENST00000371251.1_Missense_Mutation_p.M388I	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	388					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TGTATGAAATGAAAGTCAGTG	0.348000													60	57					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46244856	46244856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46244856G>A	ENST00000296140.3	-	2	1074	c.949C>T	c.(949-951)Cac>Tac	p.H317Y	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	317					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		ACACGCCTGTGGAACAACTGC	0.592000													18	33					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155203214	155203214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155203214G>A	ENST00000460012.1	-	22	3172	c.2815C>T	c.(2815-2817)Ctt>Ttt	p.L939F	PLCH1_ENST00000334686.6_Missense_Mutation_p.L939F|PLCH1_ENST00000494598.1_Missense_Mutation_p.L957F|PLCH1_ENST00000447496.2_Missense_Mutation_p.L977F|PLCH1_ENST00000340059.7_Missense_Mutation_p.L977F|PLCH1_ENST00000414191.1_Missense_Mutation_p.L939F			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	977					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GCTCCCAGAAGGTTTCTGTCA	0.468000													35	103					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519690	113519690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113519690C>T	ENST00000284601.3	-	4	1525	c.1457G>A	c.(1456-1458)cGa>cAa	p.R486Q		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	486					glycogen metabolic process	integral to membrane		p.R486Q(2)		NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GAAATCTCTTCGTAAACATCC	0.363000													11	52					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57868667	57868667	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57868667C>T	ENST00000393797.2	-	16	2104	c.1912G>A	c.(1912-1914)Gat>Aat	p.D638N	ARHGAP9_ENST00000550288.1_Missense_Mutation_p.D627N|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.D548N|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.D548N|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.D567N|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.D364N			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	567	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			CCTCTTTTATCCACAGCAGCA	0.532000													16	65					0	0	1	0	0
FOXA3	3171	broad.mit.edu	37	19	46376127	46376127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:46376127C>T	ENST00000302177.2	+	2	1061	c.864C>T	c.(862-864)ctC>ctT	p.L288L		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	288					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		GCCTGGAGCTCCCAGGGGAGC	0.607000													22	37					0	0	1	0	0
C1QTNF9B	387911	broad.mit.edu	37	13	24465965	24465965	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:24465965G>A	ENST00000382137.3	-	3	533	c.465C>T	c.(463-465)ggC>ggT	p.G155G	C1QTNF9B_ENST00000556521.1_Intron|C1QTNF9B_ENST00000382140.2_Silent_p.G155G|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B-AS1_ENST00000382133.4_RNA|C1QTNF9B_ENST00000382057.3_Intron|C1QTNF9B-AS1_ENST00000417034.1_RNA|C1QTNF9B_ENST00000382145.1_Intron	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	155	Collagen-like 3.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						TTCCAATAGGGCCCATGGGGC	0.632000													4	55					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37514853	37514853	+	Missense_Mutation	SNP	C	C	T	rs143674262		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37514853C>T	ENST00000264741.5	+	3	578	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	ITGA9_ENST00000422441.1_Missense_Mutation_p.R108W	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	108					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		AGGGAAGAATCGGGGCACGTC	0.582000													8	45					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42306227	42306227	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:42306227C>T	ENST00000379310.3	-	22	2559	c.2491G>A	c.(2491-2493)Gac>Aac	p.D831N	VWA8_ENST00000281496.6_Missense_Mutation_p.D831N	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		AAAGGTGAGTCTTCATATACA	0.343000													15	53					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72049968	72049968	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:72049968C>T	ENST00000305425.4	-	9	2312	c.1890G>A	c.(1888-1890)aaG>aaA	p.K630K	DACH1_ENST00000359684.2_Silent_p.K682K|DACH1_ENST00000354591.4_Silent_p.K428K|DACH1_ENST00000313174.7_Silent_p.K482K	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	680	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TCTTTAGCCTCTTTTGAACTA	0.333000													26	133					0	0	1	0	0
C4orf33	132321	broad.mit.edu	37	4	130023819	130023819	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:130023819C>T	ENST00000281146.4	+	2	775	c.54C>T	c.(52-54)ccC>ccT	p.P18P	C4orf33_ENST00000425929.1_Silent_p.P18P|C4orf33_ENST00000502887.1_Silent_p.P18P	NM_173487.2	NP_775758.2	Q8N1A6	CD033_HUMAN	chromosome 4 open reading frame 33	18										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	10						AGCATGAGCCCGTATTTATCA	0.403000													27	78					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307828	140307828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140307828G>A	ENST00000253807.2	+	1	1351	c.1351G>A	c.(1351-1353)Gaa>Aaa	p.E451K	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.E451K|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCCCAGCAGGAACTTTTCGT	0.527000													53	95					0	0	1	0	0
FAM83A	84985	broad.mit.edu	37	8	124206289	124206289	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124206289G>A	ENST00000518448.1	+	4	2688	c.674G>A	c.(673-675)gGa>gAa	p.G225E	FAM83A_ENST00000522648.1_Missense_Mutation_p.G169E|FAM83A_ENST00000318462.6_Missense_Mutation_p.G225E|FAM83A_ENST00000276699.6_Missense_Mutation_p.G225E|FAM83A_ENST00000536633.1_Missense_Mutation_p.G225E|FAM83A_ENST00000546351.1_Missense_Mutation_p.G169E			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	225										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AGTGTGGAAGGAGAGATATAC	0.463000													7	48					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294075	124294075	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124294075C>T	ENST00000356130.3	-	1	714	c.693G>A	c.(691-693)gaG>gaA	p.E231E		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGGATCTGCCCTCTGCAGAAG	0.438000													6	55					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43804268	43804268	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43804268G>A	ENST00000403856.1	-	11	1077	c.930C>T	c.(928-930)ctC>ctT	p.L310L	THADA_ENST00000405006.4_Silent_p.L310L|THADA_ENST00000402360.2_Silent_p.L310L|THADA_ENST00000405975.2_Silent_p.L310L|THADA_ENST00000330266.7_Silent_p.L20L|THADA_ENST00000404790.1_Silent_p.L310L|THADA_ENST00000415080.2_Silent_p.L20L			Q6YHU6	THADA_HUMAN	thyroid adenoma associated	310							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TCCCCTGACAGAGGAATAAGA	0.542000											OREG0014580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	21					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27493257	27493257	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:27493257G>A	ENST00000527372.1	-	2	882	c.702C>T	c.(700-702)tcC>tcT	p.S234S	MYO18A_ENST00000531253.1_Silent_p.S234S|MYO18A_ENST00000533112.1_Silent_p.S234S|MYO18A_ENST00000354329.4_Silent_p.S234S	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	234	PDZ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TGCGCCGCAGGGAGAAGCCAA	0.701000													30	44					0	0	1	0	0
ZFP2	80108	broad.mit.edu	37	5	178358763	178358763	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178358763G>A	ENST00000361362.2	+	5	979	c.449G>A	c.(448-450)aGa>aAa	p.R150K	ZFP2_ENST00000503510.2_Missense_Mutation_p.R150K|ZFP2_ENST00000523286.1_Missense_Mutation_p.R150K|ZFP2_ENST00000520301.1_Missense_Mutation_p.R150K	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R150I(2)		NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GTACATCAAAGAATTCATACT	0.413000													26	57					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176304662	176304662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176304662G>A	ENST00000329542.4	+	10	1867	c.1593G>A	c.(1591-1593)tgG>tgA	p.W531*	UNC5A_ENST00000261961.3_Nonsense_Mutation_p.W491*	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	531	ZU5.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGACAGCTGGAGCCTGCGCC	0.647000													11	37					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7649458	7649458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7649458C>T	ENST00000359156.4	-	5	1252	c.1050G>A	c.(1048-1050)tgG>tgA	p.W350*	CD163_ENST00000432237.2_Nonsense_Mutation_p.W350*|CD163_ENST00000396620.3_Nonsense_Mutation_p.W350*|CD163_ENST00000541972.1_Nonsense_Mutation_p.W338*	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	350	SRCR 3.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						AATGCTTTCCCCATTCATGGT	0.423000													15	57					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142641786	142641786	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142641786G>A	ENST00000355265.2	-	12	1831	c.1357C>T	c.(1357-1359)Cgc>Tgc	p.R453C		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	453					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TTTCTGAGGCGAGTGATGAGG	0.607000													4	52					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14284333	14284333	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:14284333G>A	ENST00000310358.7	+	0	2607							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		CACGTGATTCGAACCCGGATG	0.537000													4	27					0	0	1	0	0
GSTM3	2947	broad.mit.edu	37	1	110280755	110280755	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110280755A>T	ENST00000540225.1	-	6	640	c.330T>A	c.(328-330)gaT>gaA	p.D110E	RP4-735C1.4_ENST00000431955.1_RNA|GSTM3_ENST00000361066.2_Missense_Mutation_p.D110E|GSTM3_ENST00000256594.3_Missense_Mutation_p.D110E|GSTM3_ENST00000488824.1_5'UTR			P21266	GSTM3_HUMAN	glutathione S-transferase mu 3 (brain)	110	GST C-terminal.				establishment of blood-nerve barrier|glutathione metabolic process|response to estrogen stimulus	cytoplasm	glutathione transferase activity|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|skin(1)	9		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Colorectal(144;0.0339)|Lung(183;0.0426)|all cancers(265;0.113)|Epithelial(280;0.125)|COAD - Colon adenocarcinoma(174;0.134)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	GTGTGCGGAAATCCATTACTT	0.443000													21	43					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40853444	40853444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:40853444C>T	ENST00000254691.5	+	3	2209	c.2010C>T	c.(2008-2010)tcC>tcT	p.S670S	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	670					apoptosis|regulation of apoptosis	intracellular		p.S670S(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TTCAAGTTTCCTCTGGAGAAA	0.493000													53	131					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996416	140996416	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140996416C>T	ENST00000285879.4	+	4	3512	c.3226C>T	c.(3226-3228)Cat>Tat	p.H1076Y	MAGEC1_ENST00000406005.2_Missense_Mutation_p.H143Y	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1076	MAGE.						protein binding	p.H1076Y(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAAGAGCTCATTCAGAAGT	0.458000										HNSCC(15;0.026)			24	129					0	0	1	0	0
C1orf194	127003	broad.mit.edu	37	1	109649166	109649166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109649166C>T	ENST00000369949.4	-	4	573	c.394G>A	c.(394-396)Gga>Aga	p.G132R	C1orf194_ENST00000369948.3_Missense_Mutation_p.G144R|C1orf194_ENST00000369945.3_Missense_Mutation_p.G105R	NM_001122961.1	NP_001116433.1	Q5T5A4	CA194_HUMAN	chromosome 1 open reading frame 194	144										large_intestine(2)|lung(2)|ovary(2)	6						CCTATGGATCCTTGGATGCTG	0.493000													104	278					0	0	1	0	0
NXF2B	728343	broad.mit.edu	37	X	101620165	101620165	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:101620165G>A	ENST00000457521.2	-	27	3152	c.1281C>T	c.(1279-1281)ttC>ttT	p.F427F	NXF2B_ENST00000372752.1_Silent_p.F339F|NXF2B_ENST00000372749.1_Silent_p.F427F|NXF2B_ENST00000412230.2_Silent_p.F427F|NXF2B_ENST00000489531.1_5'UTR|NXF2B_ENST00000372750.1_Silent_p.F427F					nuclear RNA export factor 2B											breast(1)|kidney(1)|lung(4)|ovary(1)	7						CCTTGGGGTCGAAGGGAATAG	0.572000													19	56					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19105985	19105985	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19105985G>A	ENST00000601879.1	-	9	3393	c.3096C>T	c.(3094-3096)tcC>tcT	p.S1032S	SUGP2_ENST00000337018.6_Silent_p.S1032S|SUGP2_ENST00000452918.2_Silent_p.S1032S|SUGP2_ENST00000456085.2_Silent_p.S801S|SUGP2_ENST00000600377.1_Silent_p.S1046S			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	1032	G-patch.				mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CCTTTCCGAGGGAGCCCAGGC	0.642000													13	36					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49667581	49667581	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49667581C>T	ENST00000339139.4	-	6	443	c.207G>A	c.(205-207)acG>acA	p.T69T		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	69						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTTGGGCATTCGTTGTTACCT	0.343000													26	41					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785278	22785278	+	RNA	SNP	G	G	A	rs141007327	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22785278G>A	ENST00000600260.1	+	0	1454					NR_033899.1																						TGTGTGGGGGGACCCACCGGG	0.662000													7	15					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106602608	106602608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106602608C>T	ENST00000369701.3	+	2	913	c.686C>T	c.(685-687)tCa>tTa	p.S229L		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	229						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACTGAGAGTTCACTATGGAGG	0.502000													15	57					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164507068	164507068	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164507068C>T	ENST00000503008.1	-	6	1232	c.256G>A	c.(256-258)Gaa>Aaa	p.E86K	MARCH1_ENST00000514618.1_Missense_Mutation_p.E342K|MARCH1_ENST00000274056.7_Missense_Mutation_p.E86K|MARCH1_ENST00000339875.5_Missense_Mutation_p.E69K	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	86					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCATCCCCTTCGCAGTGACAG	0.527000													19	27					0	0	1	0	0
CCDC181	57821	broad.mit.edu	37	1	169394081	169394081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169394081C>T	ENST00000545005.1	-	3	592	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	CCDC181_ENST00000367806.3_Missense_Mutation_p.E29K|CCDC181_ENST00000367805.3_Missense_Mutation_p.E29K|CCDC181_ENST00000491570.1_5'UTR					coiled-coil domain containing 181																		TTTTCATTTTCATTAATTAAC	0.299000													19	84					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923706	24923706	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24923706C>T	ENST00000329468.2	+	1	3166	c.2692C>T	c.(2692-2694)Cat>Tat	p.H898Y		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ATCCATCTCTCATTCCACACT	0.502000													52	149					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784959	9784959	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9784959C>T	ENST00000304374.2	+	1	1702	c.1306C>T	c.(1306-1308)Cgc>Tgc	p.R436C		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	436					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.R436S(1)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TCCTTTCGATCGCATGTTCCA	0.557000													28	73					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57734081	57734081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57734081C>T	ENST00000360716.3	+	5	624	c.403C>T	c.(403-405)Ccc>Tcc	p.P135S	CCDC135_ENST00000394337.4_Missense_Mutation_p.P135S|CCDC135_ENST00000336825.8_Missense_Mutation_p.P135S|RP11-405F3.4_ENST00000563062.1_RNA			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	135						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						AACCCTCCGGCCCACACTGAT	0.572000													69	151					0	0	1	0	0
TRAF1	7185	broad.mit.edu	37	9	123667431	123667431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:123667431C>T	ENST00000373887.3	-	8	3563	c.1118G>A	c.(1117-1119)aGg>aAg	p.R373K	TRAF1_ENST00000546084.1_Missense_Mutation_p.R251K|TRAF1_ENST00000540010.1_Missense_Mutation_p.R373K	NM_005658.4	NP_005649.1	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	373	MATH.				apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(4)|pancreas(1)|skin(2)	22						ACTCTGGGGCCTCTGGAAGGA	0.587000													13	24					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125435305	125435305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125435305G>A	ENST00000308736.2	-	22	3012	c.2914C>T	c.(2914-2916)Ctt>Ttt	p.L972F	DHX37_ENST00000544745.1_Missense_Mutation_p.L759F	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	972							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TCTTTGAAAAGGACGGAGCTG	0.582000													24	54					0	0	1	0	0
HOXA6	3203	broad.mit.edu	37	7	27187241	27187241	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27187241C>T	ENST00000222728.3	-	1	152	c.128G>A	c.(127-129)gGg>gAg	p.G43E	HOXA-AS3_ENST00000518947.2_RNA|HOXA-AS3_ENST00000518848.1_RNA|HOXA6_ENST00000521478.1_Intron|HOXA-AS3_ENST00000521197.1_RNA|HOXA-AS3_ENST00000521231.1_RNA|HOXA3_ENST00000467897.2_Intron	NM_024014.3	NP_076919.1	P31267	HXA6_HUMAN	homeobox A6	43						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|lung(3)|ovary(1)	10						ACTCGACGCCCCGTACGAGGC	0.657000													19	41					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34611583	34611583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34611583G>A	ENST00000373973.3	+	11	1502	c.1329G>A	c.(1327-1329)atG>atA	p.M443I	CNBD2_ENST00000538900.1_Intron|CNBD2_ENST00000349339.1_Missense_Mutation_p.M439I					cyclic nucleotide binding domain containing 2																		TGATCCTGATGAGCCTGGGAA	0.443000													32	104					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4201420	4201420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4201420C>T	ENST00000404826.2	+	32	4871	c.4732C>T	c.(4732-4734)Cca>Tca	p.P1578S	SDK1_ENST00000389531.3_Missense_Mutation_p.P1578S	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1578	Fibronectin type-III 10.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGTTTCAGTTCCAGGAGAGCC	0.607000													31	140					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628328	173628328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173628328C>T	ENST00000333279.2	-	2	290	c.230G>A	c.(229-231)gGg>gAg	p.G77E		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	93										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						CAAATTTCTCCCAACGATGTC	0.443000													42	110					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173503725	173503725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173503725C>T	ENST00000367714.3	-	16	2294	c.1872G>A	c.(1870-1872)atG>atA	p.M624I	SLC9C2_ENST00000536496.1_Intron|SLC9C2_ENST00000466087.1_5'UTR	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	624					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										GATGTATTATCATAGGATAAA	0.259000													8	79					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10545925	10545925	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10545925T>C	ENST00000583535.1	-	16	1784	c.1697A>G	c.(1696-1698)aAg>aGg	p.K566R	MYH3_ENST00000226209.7_Missense_Mutation_p.K566R	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	566	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CACCTTGGGCTTCTGGAAGTT	0.532000													59	81					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219249050	219249050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219249050G>A	ENST00000233202.6	+	3	575	c.235G>A	c.(235-237)Gag>Aag	p.E79K	SLC11A1_ENST00000539932.1_5'UTR|SLC11A1_ENST00000473367.1_3'UTR	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	79	Pro/Ser-rich.				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGAAACATCGAGTCAGATCT	0.587000													48	140					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79458278	79458278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:79458278G>A	ENST00000264895.6	+	72	11662	c.11222G>A	c.(11221-11223)gGg>gAg	p.G3741E		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3736					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GATCCCACGGGGACAATCTAC	0.423000													33	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077159	9077159	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9077159C>T	ENST00000397910.4	-	3	10490	c.10287G>A	c.(10285-10287)tgG>tgA	p.W3429*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3430	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGATCTGACCAAGAACTAG	0.458000													52	103					0	0	1	0	0
PVRL2	5819	broad.mit.edu	37	19	45375207	45375207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45375207C>T	ENST00000252483.5	+	3	576	c.576C>T	c.(574-576)gcC>gcT	p.A192A	PVRL2_ENST00000252485.4_Silent_p.A192A	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	192	Ig-like C2-type 1.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		GCCCACCTGCCCGGATCTCCT	0.622000													14	30					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117043518	117043518	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117043518G>A	ENST00000371876.1	-	4	3380	c.959C>T	c.(958-960)tCg>tTg	p.S320L	KLHL13_ENST00000371882.1_Missense_Mutation_p.S320L|KLHL13_ENST00000539496.1_Missense_Mutation_p.S374L|KLHL13_ENST00000262820.3_Missense_Mutation_p.S371L|KLHL13_ENST00000540167.1_Missense_Mutation_p.S355L|KLHL13_ENST00000545703.1_Missense_Mutation_p.S329L|KLHL13_ENST00000541812.1_Missense_Mutation_p.S355L|KLHL13_ENST00000371878.1_Missense_Mutation_p.S320L|KLHL13_ENST00000469946.1_Missense_Mutation_p.S320L			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	371					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex		p.S371L(1)		NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GGGGGCTAACGATTTCCACTC	0.488000													41	30					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66937411	66937411	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:66937411C>T	ENST00000374690.3	+	5	2789	c.2265C>T	c.(2263-2265)ttC>ttT	p.F755F	AR_ENST00000396043.2_Silent_p.F223F|AR_ENST00000396044.3_Intron	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	754	Interaction with MYST2.|Ligand-binding.		T -> A (in prostate cancer).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GGCGATCCTTCACCAATGTCA	0.537000									Androgen Insensitivity Syndrome				23	15					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215259778	215259778	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:215259778C>T	ENST00000444842.2	+	2	264	c.114C>T	c.(112-114)tcC>tcT	p.S38S	KCNK2_ENST00000391895.2_Silent_p.S34S|KCNK2_ENST00000391894.2_Silent_p.S23S	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	38							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TCTCGTTTTCCACGAAACCCA	0.512000													18	57					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164741402	164741402	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164741402G>A	ENST00000264382.3	-	26	3117	c.3055C>T	c.(3055-3057)Cgt>Tgt	p.R1019C		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1019	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACCTCCACACGAAGAGTTGAG	0.393000										HNSCC(35;0.089)			32	106					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35740337	35740337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35740337G>A	ENST00000440995.2	+	23	3283	c.3283G>A	c.(3283-3285)Gaa>Aaa	p.E1095K	SPEF2_ENST00000356031.3_Missense_Mutation_p.E1100K|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1100					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGATGATGAGGAAACAAAGGC	0.453000													56	121					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754602	76754602	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76754602G>A	ENST00000536229.3	+	1	2921	c.2212G>A	c.(2212-2214)Gag>Aag	p.E738K	SALL3_ENST00000537592.2_Missense_Mutation_p.E871K|SALL3_ENST00000575389.2_Missense_Mutation_p.E871K			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	871					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CGGGTCCGGGGAGAGTGACCG	0.677000													15	63					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79834875	79834875	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79834875C>T	ENST00000360280.3	+	11	1020	c.760C>T	c.(760-762)Cgt>Tgt	p.R254C	VPS13A_ENST00000376634.4_Missense_Mutation_p.R254C|VPS13A_ENST00000357409.5_Missense_Mutation_p.R254C|VPS13A_ENST00000376636.3_Missense_Mutation_p.R254C	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	254					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TTCAGTATTTCGTCCCATATC	0.323000													6	86					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166850864	166850864	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166850864C>T	ENST00000423058.2	-	25	4661	c.4644G>A	c.(4642-4644)atG>atA	p.M1548I	SCN1A_ENST00000375405.3_Missense_Mutation_p.M1537I|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.M1548I|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.M1520I	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1548						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGATGAGAATCATGATGCTTA	0.368000													15	41					0	0	1	0	0
OR10G9	219870	broad.mit.edu	37	11	123894517	123894517	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123894517C>T	ENST00000375024.1	+	1	798	c.798C>T	c.(796-798)gtC>gtT	p.V266V		NM_001001953.1	NP_001001953.1	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G, member 9	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(33)|prostate(2)|skin(4)|stomach(8)|urinary_tract(1)	61		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCAGGGACGTCGTGGATGGAG	0.512000													59	127					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79983001	79983001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79983001C>T	ENST00000360280.3	+	62	8762	c.8502C>T	c.(8500-8502)ttC>ttT	p.F2834F	VPS13A_ENST00000376634.4_Silent_p.F2834F|VPS13A_ENST00000357409.5_Silent_p.F2834F|VPS13A_ENST00000376636.3_Silent_p.F2795F	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	2834					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ACTATCAGTTCCATACAACAT	0.328000													6	29					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33768033	33768033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33768033C>T	ENST00000285013.6	-	6	2550	c.2275G>A	c.(2275-2277)Ggg>Agg	p.G759R	SLFN13_ENST00000360502.2_Missense_Mutation_p.G441R|SLFN13_ENST00000526861.1_Missense_Mutation_p.G759R|SLFN13_ENST00000534689.1_Missense_Mutation_p.G441R|SLFN13_ENST00000542635.1_Missense_Mutation_p.G759R|SLFN13_ENST00000533791.1_Missense_Mutation_p.G759R	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	759						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCCAGATACCCATGGGGGATA	0.388000													41	64					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263555	39263555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:39263555C>T	ENST00000280481.7	+	1	2290	c.2074C>T	c.(2074-2076)Cgt>Tgt	p.R692C		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	692					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTTTGTGATTCGTATCCATCC	0.562000													32	104					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18754784	18754784	+	Missense_Mutation	SNP	C	C	T	rs139371305		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18754784C>T	ENST00000396170.1	-	11	2384	c.1120G>A	c.(1120-1122)Gag>Aag	p.E374K	PTPN5_ENST00000477854.1_Missense_Mutation_p.E210K|RP11-1081L13.4_ENST00000527285.1_RNA|PTPN5_ENST00000358540.2_Missense_Mutation_p.E406K|PTPN5_ENST00000396171.4_Missense_Mutation_p.E406K|PTPN5_ENST00000396167.2_Missense_Mutation_p.E374K|PTPN5_ENST00000396168.1_Missense_Mutation_p.E382K	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	406	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						GTCCCTACCTCGTTCATCTCC	0.517000													33	82					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110804801	110804801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110804801G>A	ENST00000375820.4	-	51	4929	c.4808C>T	c.(4807-4809)tCc>tTc	p.S1603F		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1603	Collagen IV NC1.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTCCAGGCAGGAGCCGGGGGA	0.597000													15	37					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178585872	178585872	+	Silent	SNP	G	G	A	rs149253571		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178585872G>A	ENST00000251582.7	-	6	1085	c.984C>T	c.(982-984)agC>agT	p.S328S	ADAMTS2_ENST00000274609.5_Silent_p.S328S	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	328	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TCTCGATGAGGCTCATGGACT	0.612000													8	26					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55652907	55652907	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55652907G>A	ENST00000449290.2	+	2	95	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	1						intracellular	zinc ion binding										TCAGAAACATGAATTCTGGAA	0.443000													50	170					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169146730	169146730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169146730G>A	ENST00000393743.3	-	34	4922	c.4631C>T	c.(4630-4632)tCc>tTc	p.S1544F		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1544							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AGCCAGTTTGGAAACAATTCG	0.333000													20	57					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183209732	183209732	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183209732C>T	ENST00000341319.3	-	7	1884	c.1849G>A	c.(1849-1851)Gga>Aga	p.G617R		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	617										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GACACTGCTCCGGGCACGATC	0.662000													13	54					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75230628	75230628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75230628C>T	ENST00000325680.7	+	1	560	c.436C>T	c.(436-438)Ccc>Tcc	p.P146S	YLPM1_ENST00000552421.1_Missense_Mutation_p.P146S|YLPM1_ENST00000238571.3_Missense_Mutation_p.P146S	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	146	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GCTGGAATCCCCCCCTGAATC	0.612000													35	41					0	0	1	0	0
GTSE1	51512	broad.mit.edu	37	22	46712010	46712010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:46712010C>T	ENST00000454366.1	+	7	1345	c.1133C>T	c.(1132-1134)cCc>cTc	p.P378L		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	359					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		AGAATGGGACCCGCCATGCTG	0.567000													38	48					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96312912	96312912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96312912C>T	ENST00000277165.6	+	12	2407	c.2213C>T	c.(2212-2214)gCc>gTc	p.A738V	FAM120A_ENST00000340893.4_Missense_Mutation_p.A738V|FAM120A_ENST00000333936.5_Missense_Mutation_p.A766V	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	738						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GAGCTAGATGCCTTCCTGGCT	0.557000													18	39					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169525903	169525903	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169525903G>A	ENST00000367796.3	-	6	1134	c.933C>T	c.(931-933)ctC>ctT	p.L311L	F5_ENST00000546081.1_Silent_p.L174L|F5_ENST00000367797.3_Silent_p.L311L			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	311	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTTTTGGGGTGAGAGAAGATA	0.478000													6	62					0	0	1	0	0
MTHFD2P1	100287639	broad.mit.edu	37	3	95374164	95374164	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:95374164C>T	ENST00000494840.1	-	0	1697					NR_077228.1																						GGAGTATATCCATGAGATATT	0.403000													18	43					0	0	1	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7675818	7675818	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:7675818G>A	ENST00000446248.2	+	10	1231		c.e10+1		CAMSAP3_ENST00000160298.4_Splice_Site	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3						epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						GCGGCAGTAGGTACGCTCCCC	0.642000													23	77					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174964	51174964	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51174964G>A	ENST00000440970.1	-	2	1309	c.878C>T	c.(877-879)cCa>cTa	p.P293L	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.P390L|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	390					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			AGGTAGAAGTGGATTAGACGC	0.522000													25	70					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390319	197390319	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197390319G>A	ENST00000367400.3	+	6	1496	c.1361G>A	c.(1360-1362)gGa>gAa	p.G454E	CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000535699.1_Missense_Mutation_p.G385E|CRB1_ENST00000543483.1_Missense_Mutation_p.G153E|CRB1_ENST00000538660.1_Missense_Mutation_p.G454E|CRB1_ENST00000544212.1_5'UTR|CRB1_ENST00000476483.1_3'UTR|CRB1_ENST00000367399.2_Missense_Mutation_p.G342E	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	454	EGF-like 11.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTAAATAATGGAACATGCATC	0.468000													37	102					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187172781	187172781	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187172781C>T	ENST00000264690.6	+	9	1196	c.1009C>T	c.(1009-1011)Cca>Tca	p.P337S	KLKB1_ENST00000513864.1_Missense_Mutation_p.P337S	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	337	Apple 4.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TTCTTTACTCCCAGAAGACTG	0.363000													27	80					0	0	1	0	0
WDR89	112840	broad.mit.edu	37	14	64066610	64066610	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:64066610G>A	ENST00000394942.2	-	2	139	c.51C>T	c.(49-51)tcC>tcT	p.S17S	WDR89_ENST00000267522.3_Silent_p.S17S	NM_001008726.2|NM_001258272.1|NM_080666.3	NP_001008726.1|NP_001245201.1|NP_542397.1	Q96FK6	WDR89_HUMAN	WD repeat domain 89	17										endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(108;0.00543)|all cancers(60;0.0181)|BRCA - Breast invasive adenocarcinoma(234;0.101)		TGGTTCCTAAGGAACATTTAA	0.363000													8	117					0	0	1	0	0
PDK2	5164	broad.mit.edu	37	17	48187418	48187418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48187418C>T	ENST00000503176.1	+	11	1342	c.1181C>T	c.(1180-1182)cCc>cTc	p.P394L	PDK2_ENST00000007708.3_Missense_Mutation_p.P330L|SAMD14_ENST00000330175.4_3'UTR	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	394					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						TGGTGTGTGCCCAGCACGGAG	0.672000									Autosomal Dominant Polycystic Kidney Disease				4	14					0	0	1	0	0
SETD4	54093	broad.mit.edu	37	21	37412927	37412927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37412927G>A	ENST00000399215.1	-	8	2382	c.1010C>T	c.(1009-1011)cCa>cTa	p.P337L	SETD4_ENST00000399212.1_Missense_Mutation_p.P313L|AP000688.1_ENST00000600312.1_Intron|SETD4_ENST00000332131.4_Missense_Mutation_p.P337L|SETD4_ENST00000481477.1_5'UTR			Q9NVD3	SETD4_HUMAN	SET domain containing 4	337				EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRL LTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKI CYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELK ILRASAETLHSLQTAFT -> GWNQLCS (in Ref. 5; AAH02898).						autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						CCTCCAAGATGGTCCATCCCA	0.383000													64	181					0	0	1	0	0
HADHB	3032	broad.mit.edu	37	2	26486319	26486319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:26486319C>T	ENST00000317799.5	+	4	285	c.181C>T	c.(181-183)Cgc>Tgc	p.R61C	HADHB_ENST00000494615.1_3'UTR|HADHB_ENST00000405867.3_Missense_Mutation_p.R61C|HADHB_ENST00000545822.1_Missense_Mutation_p.R39C|HADHB_ENST00000537713.1_Missense_Mutation_p.R61C	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	61			R -> C (in TFP deficiency).|R -> H (in TFP deficiency).		fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGATGGTGTTCGCACTCCATT	0.348000													37	105					0	0	1	0	0
SGPP2	130367	broad.mit.edu	37	2	223386575	223386575	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:223386575G>A	ENST00000321276.7	+	3	554	c.468G>A	c.(466-468)ctG>ctA	p.L156L		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	156					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		AAAAGAGACTGATCGCTGAAT	0.522000													29	84					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106124630	106124630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106124630G>A	ENST00000369704.3	+	4	714	c.580G>A	c.(580-582)Gaa>Aaa	p.E194K	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	194										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AGAGGAGGCTGAACATGCCAT	0.488000													18	39					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182763211	182763211	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:182763211C>T	ENST00000492597.1	-	9	1448	c.746G>A	c.(745-747)tGg>tAg	p.W249*	MCCC1_ENST00000539926.1_Nonsense_Mutation_p.W223*|MCCC1_ENST00000265594.4_Nonsense_Mutation_p.W358*			Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	358	ATP-grasp.|Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	TCTAAGCTGCCACTCCACCAA	0.458000													27	82					0	0	1	0	0
TNFRSF4	7293	broad.mit.edu	37	1	1147102	1147102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1147102C>T	ENST00000379236.3	-	6	749	c.745G>A	c.(745-747)Gat>Aat	p.D249N		NM_003327.3	NP_003318.1	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily, member 4	249					immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity			large_intestine(1)|lung(2)|urinary_tract(1)	4	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTGTGGGCATCGGGGGGCAGC	0.706000													8	8					0	0	1	0	0
MAB21L3	126868	broad.mit.edu	37	1	116675774	116675774	+	Missense_Mutation	SNP	G	G	A	rs150571972		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:116675774G>A	ENST00000369500.3	+	7	1142	c.877G>A	c.(877-879)Gag>Aag	p.E293K		NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	293										breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						TTGGACCTGCGAGAAATATCC	0.478000													15	30					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205272864	205272864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205272864G>A	ENST00000367157.3	-	7	1727	c.1601C>T	c.(1600-1602)gCc>gTc	p.A534V		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	534					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCTGGCCCGGGCCAGGGGGCG	0.652000													31	55					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2898716	2898716	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:2898716C>T	ENST00000254695.8	+	13	1090	c.1000C>T	c.(1000-1002)Cac>Tac	p.H334Y	RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.H334Y|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.H315Y|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.H319Y	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	334	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GATCATGTTTCACGTTTCCAC	0.587000													62	55					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46851304	46851304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46851304C>T	ENST00000283296.7	-	6	892	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	GPR116_ENST00000265417.7_Missense_Mutation_p.E202K|GPR116_ENST00000456426.2_Missense_Mutation_p.E202K|GPR116_ENST00000362015.4_Missense_Mutation_p.E202K	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	202	SEA.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			ACCGCTGTTTCCAAGTCGGTC	0.448000													12	29					0	0	1	0	0
TBC1D14	57533	broad.mit.edu	37	4	7026910	7026910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:7026910C>T	ENST00000409757.4	+	13	2061	c.1937C>T	c.(1936-1938)cCc>cTc	p.P646L	TBC1D14_ENST00000448507.1_Missense_Mutation_p.P646L|TBC1D14_ENST00000410031.1_Missense_Mutation_p.P418L|TBC1D14_ENST00000451522.2_Missense_Mutation_p.P366L|TBC1D14_ENST00000446947.2_Missense_Mutation_p.P293L	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	646						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						ACCCGGCTGCCCGAGGACCTG	0.597000													29	55					0	0	1	0	0
SV2C	22987	broad.mit.edu	37	5	75596679	75596679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:75596679C>T	ENST00000502798.2	+	11	2204	c.1762C>T	c.(1762-1764)Ctg>Ttg	p.L588L	RP11-466P24.6_ENST00000502589.1_RNA|SV2C_ENST00000322285.7_Silent_p.L588L	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	588					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TGTCAACTTTCTGGGGACATT	0.413000													40	184					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49578756	49578756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49578756C>T	ENST00000371175.4	-	7	1074	c.1048G>A	c.(1048-1050)Gca>Aca	p.A350T	RHAG_ENST00000229810.7_Intron	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	350					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					GCGCCCATTGCTACTGCCACA	0.478000													34	58					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1079932	1079932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1079932G>A	ENST00000313093.2	+	13	1749	c.1518G>A	c.(1516-1518)acG>acA	p.T506T	HMHA1_ENST00000543365.1_Silent_p.T389T|HMHA1_ENST00000539243.2_Silent_p.T522T|HMHA1_ENST00000586866.1_Silent_p.T510T|HMHA1_ENST00000590577.1_Silent_p.T141T|HMHA1_ENST00000590214.1_Silent_p.T533T|HMHA1_ENST00000536472.1_Silent_p.T346T	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	506					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCAGGCCACGATCTCCTACT	0.677000													59	115					0	0	1	0	0
LAYN	143903	broad.mit.edu	37	11	111425979	111425979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111425979G>A	ENST00000436913.2	+	4	588	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	LAYN_ENST00000375615.3_Missense_Mutation_p.E216K|LAYN_ENST00000528924.1_3'UTR|LAYN_ENST00000533265.1_Missense_Mutation_p.E208K|LAYN_ENST00000525126.1_Missense_Mutation_p.E216K|LAYN_ENST00000375614.2_Missense_Mutation_p.E208K	NM_001258391.1	NP_001245320.1	Q6UX15	LAYN_HUMAN	layilin	216	C-type lectin.					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|skin(1)	14		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		AGAAACACAGGAAGAAGATGC	0.398000													18	39					0	0	1	0	0
FABP2	2169	broad.mit.edu	37	4	120240735	120240735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:120240735C>T	ENST00000274024.3	-	3	591	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K		NM_000134.3	NP_000125.2	P12104	FABPI_HUMAN	fatty acid binding protein 2, intestinal	102							fatty acid binding	p.E102K(1)		breast(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	8						GTATTCAGTTCGTTTCCATTG	0.308000													23	53					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4544408	4544408	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4544408G>A	ENST00000586582.1	-	17	2182	c.1872C>T	c.(1870-1872)ctC>ctT	p.L624L	SEMA6B_ENST00000586965.1_Intron|SEMA6B_ENST00000301293.3_Silent_p.L624L	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	624					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGCTCACGGAGGCCCACGA	0.731000													9	20					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98288972	98288972	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:98288972C>T	ENST00000322128.3	-	1	1204	c.1101G>A	c.(1099-1101)gaG>gaA	p.E367E		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	367					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					CGTTGATTATCTCCACAATCT	0.463000													57	207					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64769444	64769444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:64769444C>T	ENST00000536360.1	-	2	870	c.57G>A	c.(55-57)tcG>tcA	p.S19S				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	19					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.S19S(1)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TATGAAATTCCGATGAAGCCA	0.363000													45	128					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	184002751	184002751	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184002751G>A	ENST00000402825.3	+	9	1360	c.1359_splice	c.e9-1	p.A454_splice	EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000357474.5_Splice_Site_p.A382_splice|ECE2_ENST00000404464.3_Splice_Site_p.A336_splice|ECE2_ENST00000359140.4_Splice_Site_p.A307_splice	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	454	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTTCTTTCAGGCTCTGGCGCC	0.547000											OREG0015945	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	43					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44079588	44079588	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:44079588G>A	ENST00000272286.2	+	5	747	c.657G>A	c.(655-657)agG>agA	p.R219R		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	219	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GTGAGCGCAGGAGAGTCAGCA	0.677000													22	34					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136597649	136597649	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136597649C>T	ENST00000371872.4	-	3	663	c.406G>A	c.(406-408)Gag>Aag	p.E136K	SARDH_ENST00000298628.5_Missense_Mutation_p.E136K|SARDH_ENST00000439388.1_Missense_Mutation_p.E136K|SARDH_ENST00000371867.1_Missense_Mutation_p.E47K|SARDH_ENST00000422262.2_5'UTR	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	136					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TCCTCCAGCTCCCGGCTCACC	0.672000													33	148					0	0	1	0	0
SFPQ	6421	broad.mit.edu	37	1	35652632	35652632	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35652632G>A	ENST00000357214.5	-	9	2054	c.1956C>T	c.(1954-1956)acC>acT	p.T652T		NM_005066.2	NP_005057.1	P23246	SFPQ_HUMAN	splicing factor proline/glutamine-rich	652					alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|RNA binding		SFPQ/TFE3(6)	NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				AACCACTCATGGTTGCTGGTG	0.453000			T	TFE3	papillary renal cell								39	67					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94645345	94645345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94645345G>A	ENST00000260526.6	-	20	2598	c.2416C>T	c.(2416-2418)Ctt>Ttt	p.L806F	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	806	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TGTCTTAGAAGGTCTTTGCTT	0.289000													35	90					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124401062	124401062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124401062G>A	ENST00000409039.3	+	62	10452	c.10427G>A	c.(10426-10428)gGg>gAg	p.G3476E		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3476	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATAAAGTACGGGACCCCTTTC	0.453000													16	113					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34180240	34180240	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:34180240C>T	ENST00000262622.3	+	2	831	c.73C>T	c.(73-75)Ctc>Ttc	p.L25F	CHST8_ENST00000438847.2_Missense_Mutation_p.L25F|CHST8_ENST00000434302.1_Missense_Mutation_p.L25F|CHST8_ENST00000604556.1_Missense_Mutation_p.L25F	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	25					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					AGCTGCAGGCCTCCTCCTCTT	0.637000													42	101					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104048474	104048474	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104048474G>A	ENST00000388887.2	+	13	1753	c.1549G>A	c.(1549-1551)Gag>Aag	p.E517K		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	517	FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GAGCAACAATGAGGTGAGTAT	0.463000													32	86					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14160012	14160012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14160012C>T	ENST00000263379.2	+	10	1413	c.1288C>T	c.(1288-1290)Cca>Tca	p.P430S		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	430	Fibronectin type-III 3.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						AGATGCCCCTCCAGGGACCCC	0.647000											OREG0025303	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	51					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884217	228884217	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228884217G>A	ENST00000392056.3	-	7	1399	c.1353C>T	c.(1351-1353)gtC>gtT	p.V451V	SPHKAP_ENST00000344657.5_Silent_p.V451V	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	451						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTGAACAACGACGATTTTGG	0.507000													27	78					0	0	1	0	0
OXSR1	9943	broad.mit.edu	37	3	38266165	38266165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38266165C>T	ENST00000311806.3	+	8	1178	c.806C>T	c.(805-807)tCa>tTa	p.S269L	OXSR1_ENST00000446845.1_Missense_Mutation_p.S269L	NM_005109.2	NP_005100.1	O95747	OXSR1_HUMAN	oxidative stress responsive 1	269	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AAAATGATTTCATTGTGCCTT	0.313000													13	40					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115406706	115406706	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115406706C>T	ENST00000369358.4	-	10	1213	c.969G>A	c.(967-969)aaG>aaA	p.K323K	NRAP_ENST00000360478.3_Silent_p.K323K|NRAP_ENST00000369360.3_Silent_p.K323K|NRAP_ENST00000359988.3_Silent_p.K323K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	323						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CGTGAGCTTTCTTGGCGTTCT	0.522000													34	86					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42901011	42901011	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42901011G>A	ENST00000372565.3	-	6	1032	c.763C>T	c.(763-765)Ctc>Ttc	p.L255F	ZMYND12_ENST00000433602.2_Missense_Mutation_p.L145F|ZMYND12_ENST00000475426.1_5'UTR	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	255						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCTGTGAGAGGACTTGATAG	0.473000													71	193					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55913032	55913032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55913032C>T	ENST00000373965.2	-	15	2027	c.1633G>A	c.(1633-1635)Gaa>Aaa	p.E545K	PCDH15_ENST00000395445.1_Missense_Mutation_p.E545K|PCDH15_ENST00000373957.3_Missense_Mutation_p.E516K|PCDH15_ENST00000395446.1_Missense_Mutation_p.E538K|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.E543K|PCDH15_ENST00000395433.1_Missense_Mutation_p.E516K|PCDH15_ENST00000395430.1_Missense_Mutation_p.E538K|PCDH15_ENST00000373955.1_Missense_Mutation_p.E538K|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000361849.3_Missense_Mutation_p.E538K|PCDH15_ENST00000395438.1_Missense_Mutation_p.E538K|PCDH15_ENST00000409834.1_Missense_Mutation_p.E149K|PCDH15_ENST00000437009.1_Missense_Mutation_p.E538K|PCDH15_ENST00000320301.6_Missense_Mutation_p.E538K|PCDH15_ENST00000395432.2_Missense_Mutation_p.E501K	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	538	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.E543K(2)|p.E538K(2)		NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTGACCCTTCGTCTGCGTCG	0.458000										HNSCC(58;0.16)			12	144					0	0	1	0	0
ANKZF1	55139	broad.mit.edu	37	2	220097337	220097337	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220097337C>T	ENST00000323348.5	+	5	664	c.490C>T	c.(490-492)Cga>Tga	p.R164*	ANKZF1_ENST00000410034.3_Nonsense_Mutation_p.R164*|ANKZF1_ENST00000409849.1_5'UTR	NM_018089.2	NP_060559.2	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing 1	164						intracellular	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	23		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTACCCTCATCGAGTTCTTTT	0.537000													35	90					0	0	1	0	0
MORN1	79906	broad.mit.edu	37	1	2288981	2288981	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2288981G>A	ENST00000378531.3	-	10	1099	c.926C>T	c.(925-927)cCc>cTc	p.P309L	MORN1_ENST00000378529.3_Missense_Mutation_p.P309L|MORN1_ENST00000606372.1_5'UTR	NM_024848.1	NP_079124.1	Q5T089	MORN1_HUMAN	MORN repeat containing 1	309										breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(1)|ovary(2)	9	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		GGCAGCTCTGGGCCCCGGCAC	0.657000													37	101					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73069424	73069424	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73069424G>A	ENST00000429829.1	-	0	3164					NR_001564.2																						GCTCTCAATTGACATTCCCTA	0.393000													17	13					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427318	135427318	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135427318C>T	ENST00000394143.1	+	6	1744	c.1453C>T	c.(1453-1455)Cct>Tct	p.P485S	GPR112_ENST00000370652.1_Missense_Mutation_p.P485S|GPR112_ENST00000287534.4_Missense_Mutation_p.P422S|GPR112_ENST00000394141.1_Missense_Mutation_p.P280S|GPR112_ENST00000412101.1_Missense_Mutation_p.P280S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	485					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TTCTGTATTTCCTAGAAACCA	0.448000													28	40					0	0	1	0	0
MTMR12	54545	broad.mit.edu	37	5	32239246	32239246	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:32239246G>A	ENST00000382142.3	-	13	1375	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	MTMR12_ENST00000280285.5_Missense_Mutation_p.S402F|MTMR12_ENST00000264934.5_Missense_Mutation_p.S402F	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	402	Myotubularin phosphatase.					cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						CACCAGAGAGGAAATGAGACA	0.502000													14	52					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154687474	154687474	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154687474C>T	ENST00000271915.3	-	6	2022	c.1707G>A	c.(1705-1707)aaG>aaA	p.K569K	KCNN3_ENST00000358505.2_Silent_p.K256K|KCNN3_ENST00000361147.4_Silent_p.K264K	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	574	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			CTGCAGCATTCTTGATCTAAG	0.393000													29	99					0	0	1	0	0
PER1	5187	broad.mit.edu	37	17	8049772	8049772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8049772G>A	ENST00000317276.4	-	16	2193	c.1956C>T	c.(1954-1956)gcC>gcT	p.A652A	PER1_ENST00000578089.1_5'UTR|PER1_ENST00000581082.1_Silent_p.A632A|PER1_ENST00000354903.5_Silent_p.A636A	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	652	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						AGGAGGAGGAGGCACATTTAC	0.592000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					21	43					0	0	1	0	0
PAPD4	167153	broad.mit.edu	37	5	78915544	78915544	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:78915544C>T	ENST00000453514.1	+	2	766	c.73C>T	c.(73-75)Ctg>Ttg	p.L25L	PAPD4_ENST00000423041.2_Silent_p.L25L|PAPD4_ENST00000504233.1_Silent_p.L25L|PAPD4_ENST00000428308.2_Silent_p.L25L|PAPD4_ENST00000296783.3_Silent_p.L25L	NM_001114394.1	NP_001107866.1	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	25					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			biliary_tract(1)|breast(2)|endometrium(4)|kidney(3)|large_intestine(9)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		CTTCTTTACCCTGTCACCTAC	0.408000													27	79					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62398281	62398281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62398281G>A	ENST00000346178.4	-	12	1259	c.1244C>T	c.(1243-1245)tCc>tTc	p.S415F	GANAB_ENST00000356638.3_Missense_Mutation_p.S393F|GANAB_ENST00000540933.1_Missense_Mutation_p.S296F|GANAB_ENST00000534779.1_Missense_Mutation_p.S301F	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	393					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						GTAGCCGAGGGAGAAGAGTGG	0.582000													7	21					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237405806	237405806	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237405806G>A	ENST00000409907.3	-	2	610	c.336_splice	c.e2+1	p.P112_splice	IQCA1_ENST00000431676.2_Splice_Site_p.P112_splice|IQCA1_ENST00000309507.5_Splice_Site_p.P108_splice			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	112							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						GAGTGCTTACGGGGGCCAGCT	0.448000													10	7					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132061443	132061443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:132061443C>T	ENST00000336375.5	+	6	693	c.603C>T	c.(601-603)gaC>gaT	p.D201D	ACPP_ENST00000475741.1_Silent_p.D168D|ACPP_ENST00000351273.7_Silent_p.D201D	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	201						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						ATGGCCAGGACCTTTTTGGAA	0.353000													16	112					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31712336	31712336	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:31712336C>T	ENST00000396556.2	-	9	1988	c.1866G>A	c.(1864-1866)gcG>gcA	p.A622A	OSBPL10_ENST00000438237.2_Silent_p.A558A	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	622					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		ATATCACTGTCGCTGAGTACC	0.547000													44	98					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55973911	55973911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55973911C>T	ENST00000263923.4	-	10	1700	c.1405G>A	c.(1405-1407)Gag>Aag	p.E469K		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	469	Ig-like C2-type 5.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACCTGGGCTCGTTGGCGCAC	0.512000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			27	66					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420389	55420389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55420389G>A	ENST00000242994.3	+	2	544	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	56	Asp/Glu-rich (acidic).				amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						CAGTATTgaggaagaagaaga	0.478000													17	44					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71510219	71510219	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71510219G>A	ENST00000396073.3	+	9	3357	c.3076G>A	c.(3076-3078)Gaa>Aaa	p.E1026K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	1026					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel	p.E1026Q(1)		haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			TACACCTGATGAAGGCTCCAA	0.433000													20	93					0	0	1	0	0
HOOK1	51361	broad.mit.edu	37	1	60328519	60328519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60328519G>A	ENST00000371208.3	+	16	1853	c.1596G>A	c.(1594-1596)caG>caA	p.Q532Q	HOOK1_ENST00000395561.2_Silent_p.Q490Q|HOOK1_ENST00000465876.1_3'UTR	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1	532	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					AATCTTTACAGGAACAAGGTT	0.368000													21	94					0	0	1	0	0
OR1Q1	158131	broad.mit.edu	37	9	125377471	125377471	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125377471C>T	ENST00000297913.2	+	1	524	c.455C>T	c.(454-456)tCc>tTc	p.S152F	RP11-64P14.7_ENST00000431442.1_RNA	NM_012364.1	NP_036496.1	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q, member 1	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	17						CATGCTCTCTCCCACCTTCAT	0.488000													35	96					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30670603	30670603	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30670603G>A	ENST00000376406.3	-	13	6564	c.5917C>T	c.(5917-5919)Cct>Tct	p.P1973S	MDC1_ENST00000376405.2_Missense_Mutation_p.P1709S	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1973	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TCTTGCTCAGGGTCGGTCACC	0.547000								Other conserved DNA damage response genes					39	123					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15383628	15383628	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15383628G>A	ENST00000263377.2	-	2	504	c.283C>T	c.(283-285)Cct>Tct	p.P95S	BRD4_ENST00000360016.5_Missense_Mutation_p.P95S|BRD4_ENST00000371835.4_Missense_Mutation_p.P95S	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	95	Bromo 1.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			CTACTCACAGGGAGGTTCAGC	0.592000			T	C15orf55	lethal midline carcinoma of young people								6	24					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166847761	166847761	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166847761C>T	ENST00000423058.2	-	26	6041	c.6024G>A	c.(6022-6024)ggG>ggA	p.G2008G	SCN1A_ENST00000375405.3_Silent_p.G1997G|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Silent_p.G2008G|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.G1980G	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	2008						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	tcatttatttCCCTTTGGCTT	0.393000													12	19					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165861	151165861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:151165861G>A	ENST00000282466.3	-	4	1907	c.1908C>T	c.(1906-1908)acC>acT	p.T636T		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	636	Ig-like C2-type 2.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTCTTTCGGGGTGACCTGTA	0.418000													31	95					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155295167	155295167	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:155295167C>T	ENST00000392825.3	+	12	2026	c.1459C>T	c.(1459-1461)Ctc>Ttc	p.L487F	AC009227.2_ENST00000434635.1_RNA|GALNT13_ENST00000487047.1_3'UTR|GALNT13_ENST00000409237.1_Missense_Mutation_p.L487F	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	487	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						TGTTTCTAGACTCAATGGACC	0.318000													35	90					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434304	72434304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:72434304C>T	ENST00000373517.3	-	1	380	c.25G>A	c.(25-27)Gag>Aag	p.E9K	NAP1L2_ENST00000536638.1_Intron	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	9					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TCTGACAGCTCCTTGCGGTTC	0.547000													25	32					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59962333	59962333	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59962333G>A	ENST00000444766.3	-	16	2117	c.2042C>T	c.(2041-2043)tCt>tTt	p.S681F	INTS2_ENST00000251334.6_Missense_Mutation_p.S673F	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	681					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						CATTAAAGAAGAAGAATATGA	0.353000													7	18					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095062	69095062	+	Missense_Mutation	SNP	G	G	A	rs150665678		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69095062G>A	ENST00000332644.5	-	8	1020	c.859C>T	c.(859-861)Cgt>Tgt	p.R287C		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	287	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						CAAATCTTACGAATGTACTCT	0.358000													31	84					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57537224	57537224	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57537224C>T	ENST00000371236.2	-	6	792	c.529G>A	c.(529-531)Gat>Aat	p.D177N	DAB1_ENST00000371231.1_Missense_Mutation_p.D177N|DAB1_ENST00000439789.2_Intron|DAB1_ENST00000371234.4_Missense_Mutation_p.D177N|DAB1_ENST00000420954.2_Missense_Mutation_p.D177N|DAB1_ENST00000371230.1_Missense_Mutation_p.D177N|DAB1_ENST00000414851.2_Missense_Mutation_p.D177N|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	177	PID.				cell differentiation|nervous system development			p.D177Y(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CACTGCTTATCCTTTTGTGCC	0.393000													27	61					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4513602	4513602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4513602C>T	ENST00000301286.3	-	3	327	c.328G>A	c.(328-330)Ggc>Agc	p.G110S		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	110	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						GTGTCCAGGCCTCCCTGGACC	0.657000													5	11					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92191472	92191472	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92191472G>A	ENST00000256343.3	-	3	276	c.120C>T	c.(118-120)ttC>ttT	p.F40F		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	40					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TCTCTTGAGGGAACCCTTTGT	0.313000													14	34					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71892314	71892314	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71892314G>A	ENST00000258104.3	+	46	5357	c.5080G>A	c.(5080-5082)Gac>Aac	p.D1694N	DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000394120.2_Missense_Mutation_p.D1695N|DYSF_ENST00000409744.1_Missense_Mutation_p.D1702N|DYSF_ENST00000410020.3_Missense_Mutation_p.D1733N|DYSF_ENST00000413539.2_Missense_Mutation_p.D1725N|DYSF_ENST00000429174.2_Missense_Mutation_p.D1715N|DYSF_ENST00000409366.1_Missense_Mutation_p.D1716N|DYSF_ENST00000409582.3_Missense_Mutation_p.D1732N|DYSF_ENST00000409762.1_Missense_Mutation_p.D1711N|DYSF_ENST00000409651.1_Missense_Mutation_p.D1726N|DYSF_ENST00000410041.1_Missense_Mutation_p.D1712N	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1694						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						CCAGTGGCGGGACCAGCTCCG	0.562000													67	115					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17794534	17794534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:17794534G>A	ENST00000378814.5	-	25	3167	c.3168C>T	c.(3166-3168)atC>atT	p.I1056I	KIF13A_ENST00000378843.2_Silent_p.I1056I|KIF13A_ENST00000259711.6_Silent_p.I1056I|KIF13A_ENST00000378816.5_Silent_p.I1056I|KIF13A_ENST00000378826.2_Silent_p.I1056I	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1056					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTACACAGCCGATGGATACTG	0.468000													38	92					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96777479	96777479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96777479G>A	ENST00000359933.4	-	28	5029	c.4136C>T	c.(4135-4137)cCt>cTt	p.P1379L	ATG2B_ENST00000261834.5_5'UTR	NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1379										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AAAGGCTCCAGGCTTCATATC	0.448000													38	121					0	0	1	0	0
APLP2	334	broad.mit.edu	37	11	130011906	130011906	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:130011906C>T	ENST00000263574.5	+	17	2199	c.2127C>T	c.(2125-2127)atC>atT	p.I709I	APLP2_ENST00000338167.5_Silent_p.I697I|APLP2_ENST00000528499.1_Silent_p.I641I|APLP2_ENST00000345598.5_Silent_p.I468I|APLP2_ENST00000278756.7_Silent_p.I707I|APLP2_ENST00000543137.1_Silent_p.I604I|APLP2_ENST00000539648.1_Silent_p.I497I	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	709					G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CCACGGTCATCGTCATCAGCC	0.602000													13	23					0	0	1	0	0
SH3BP4	23677	broad.mit.edu	37	2	235949554	235949554	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:235949554C>T	ENST00000409212.1	+	4	648	c.141C>T	c.(139-141)ctC>ctT	p.L47L	SH3BP4_ENST00000344528.4_Silent_p.L47L|SH3BP4_ENST00000392011.2_Silent_p.L47L			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	47					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GTGCCTTGCTCGTAGACAACC	0.542000													41	97					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	156195	156195	+	Missense_Mutation	SNP	G	G	A	rs138938524		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156195G>A	ENST00000283426.6	+	8	1200	c.1150G>A	c.(1150-1152)Gag>Aag	p.E384K		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	384					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.E384K(2)|p.E384*(1)		endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GGAAGTCGCCGAGTTAATTGA	0.582000													13	75					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39325115	39325115	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39325115C>T	ENST00000287152.7	-	19	2212	c.2118G>A	c.(2116-2118)acG>acA	p.T706T	KIF6_ENST00000394362.1_Silent_p.T157T|KIF6_ENST00000373215.3_Silent_p.T689T|KIF6_ENST00000541946.1_Silent_p.T157T|KIF6_ENST00000229913.5_Silent_p.T157T|KIF6_ENST00000538893.1_Silent_p.T650T|KIF6_ENST00000373216.3_Silent_p.T706T|KIF6_ENST00000373213.4_Silent_p.T545T	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	706					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GAAATGGCTTCGTGTGATCGA	0.458000													38	91					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6964814	6964814	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6964814G>A	ENST00000278319.5	+	6	1242	c.654G>A	c.(652-654)ttG>ttA	p.L218L	ZNF215_ENST00000414517.2_Silent_p.L218L|ZNF215_ENST00000527171.1_3'UTR|ZNF215_ENST00000529903.1_Silent_p.L218L	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	218	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		GCCTTAAGTTGGAGAGTAAGA	0.343000													54	120					0	0	1	0	0
SIRPB2	284759	broad.mit.edu	37	20	1456817	1456817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1456817C>T	ENST00000359801.3	-	5	1060	c.1024G>A	c.(1024-1026)Gag>Aag	p.E342K	SIRPB2_ENST00000444444.1_Missense_Mutation_p.E244K	NM_001122962.1	NP_001116434.1	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	342						integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						ACCCCTCACTCTTGACCCTTG	0.612000													30	94					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531707	50531707	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50531707C>T	ENST00000374144.3	+	3	1405	c.1117C>T	c.(1117-1119)Caa>Taa	p.Q373*	C10orf71_ENST00000323868.4_Nonsense_Mutation_p.Q373*			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	373										endometrium(1)	1						ACCTGATTCTCAAGAGAAGCC	0.512000													16	69					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17603053	17603053	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17603053C>T	ENST00000375460.3	+	12	1387	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	449					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGCGGGACTTCCTCCATGCCC	0.552000													20	80					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95604162	95604162	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95604162G>A	ENST00000343958.4	-	2	1121	c.898C>T	c.(898-900)Ccc>Tcc	p.P300S	FGD6_ENST00000549499.1_Missense_Mutation_p.P300S|FGD6_ENST00000546711.1_Missense_Mutation_p.P300S	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	300					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						ATTTCTAAGGGACCAAGGTCT	0.403000													42	108					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12969363	12969363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12969363G>A	ENST00000251472.4	+	12	1215	c.1176G>A	c.(1174-1176)cgG>cgA	p.R392R	MAST1_ENST00000591495.1_Silent_p.R388R	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	392	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						ACCTGGTGCGGCACCGCGACA	0.657000													21	57					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120801536	120801536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:120801536G>A	ENST00000369144.3	-	19	3623	c.3496C>T	c.(3496-3498)Cct>Tct	p.P1166S	EIF3A_ENST00000541549.1_Missense_Mutation_p.P1132S|EIF3A_ENST00000478852.1_Intron	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	1166	25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].|Asp-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CAAGGACCAGGTCTTGAGTCA	0.443000													21	66					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55569295	55569295	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:55569295C>T	ENST00000395438.1	-	36	4959	c.4565G>A	c.(4564-4566)aGa>aAa	p.R1522K	PCDH15_ENST00000395445.1_Silent_p.K1505K|PCDH15_ENST00000395446.1_Silent_p.K701K|PCDH15_ENST00000395442.1_Silent_p.K370K|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395440.1_Silent_p.K439K|PCDH15_ENST00000409834.1_Missense_Mutation_p.R1133K	NM_001142770.1	NP_001136242.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTTAATTTTCTTTGGCTCTT	0.403000										HNSCC(58;0.16)			45	231					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17496474	17496474	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17496474G>A	ENST00000302539.4	-	2	374	c.249C>T	c.(247-249)ttC>ttT	p.F83F	ABCC8_ENST00000389817.3_Silent_p.F83F	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	83					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACACCAGGACGAAGAGCAGCA	0.547000													19	50					0	0	1	0	0
ACTR1A	10121	broad.mit.edu	37	10	104241922	104241922	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104241922G>A	ENST00000369905.4	-	8	824	c.761C>T	c.(760-762)tCc>tTc	p.S254F	ACTR1A_ENST00000487599.1_Missense_Mutation_p.S254F|ACTR1A_ENST00000470322.1_5'UTR|ACTR1A_ENST00000545684.1_Missense_Mutation_p.S180F|ACTR1A_ENST00000446605.2_Missense_Mutation_p.S207F	NM_005736.3	NP_005727.1	P61163	ACTZ_HUMAN	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)	254					G2/M transition of mitotic cell cycle|vesicle-mediated transport	centrosome|cytosol|dynactin complex	ATP binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	13		Colorectal(252;0.122)		Epithelial(162;5.34e-09)|all cancers(201;1.43e-07)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CCGGAATCGGGAAGGACCAAT	0.582000													35	114					0	0	1	0	0
C10orf128	170371	broad.mit.edu	37	10	50396355	50396355	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50396355C>T	ENST00000374148.1	-	1	81	c.27G>A	c.(25-27)agG>agA	p.R9R	C10orf128_ENST00000474718.1_Silent_p.R9R|C10orf128_ENST00000470884.1_5'UTR|C10orf128_ENST00000374153.2_Silent_p.R9R|C10orf128_ENST00000374151.3_Silent_p.R9R			Q5T292	CJ128_HUMAN	chromosome 10 open reading frame 128	9						integral to membrane				breast(1)|large_intestine(1)|lung(1)	3						GGAAGAGGATCCTCAGCATGC	0.647000													26	84					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286549	152286549	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152286549C>T	ENST00000368799.1	-	3	848	c.813G>A	c.(811-813)gtG>gtA	p.V271V	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	271	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGACCTGTTCACTTGAGATG	0.438000									Ichthyosis				27	309					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36050801	36050801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36050801G>A	ENST00000262623.3	-	7	990	c.962C>T	c.(961-963)gCc>gTc	p.A321V		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	321					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AATGCACATGGCCACAATAAA	0.547000													31	58					0	0	1	0	0
GRIN2C	2905	broad.mit.edu	37	17	72842210	72842210	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72842210C>T	ENST00000293190.5	-	11	2491	c.2345G>A	c.(2344-2346)gGg>gAg	p.G782E	GRIN2C_ENST00000347612.4_Missense_Mutation_p.G782E	NM_000835.3	NP_000826.2	Q14957	NMDE3_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	782					glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	33	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CCCACCGTCCCCCAGGAACTG	0.612000													34	104					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31590878	31590878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31590878C>T	ENST00000379416.3	-	20	2194	c.2146G>A	c.(2146-2148)Gag>Aag	p.E716K		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	716					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity	p.E716*(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TCCCCTTTCTCGATCTTCAGC	0.468000													109	71					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31920407	31920407	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31920407C>T	ENST00000396184.3	-	4	399	c.195G>A	c.(193-195)ttG>ttA	p.L65L	PDE1C_ENST00000396182.2_Silent_p.L65L|PDE1C_ENST00000396191.1_Silent_p.L65L|PDE1C_ENST00000321453.7_Silent_p.L65L|PDE1C_ENST00000396193.1_Silent_p.L125L	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	65					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			CTGCATATTCCAAATTCTTCT	0.308000													51	114					0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156877930	156877930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156877930G>A	ENST00000338302.3	+	10	1138	c.913G>A	c.(913-915)Gag>Aag	p.E305K	PEAR1_ENST00000292357.7_Missense_Mutation_p.E305K			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	305						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTGCCGGGAGGAGTGCCCGGT	0.711000													4	14					0	0	1	0	0
SPSB1	80176	broad.mit.edu	37	1	9416153	9416153	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9416153A>G	ENST00000328089.6	+	2	544	c.203A>G	c.(202-204)aAg>aGg	p.K68R	SPSB1_ENST00000357898.3_Missense_Mutation_p.K68R|SPSB1_ENST00000377399.2_Missense_Mutation_p.K68R	NM_025106.3	NP_079382.2	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box containing 1	68	B30.2/SPRY.				intracellular signal transduction	cytoplasm				breast(1)|endometrium(3)|kidney(2)|lung(5)|prostate(2)	13	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		GTCTTTGTGAAGGAGGACGAC	0.577000													51	165					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54805618	54805618	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:54805618C>T	ENST00000306858.7	+	5	1965	c.1849C>T	c.(1849-1851)Cct>Tct	p.P617S		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	617										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					CTTGCAGGTTCCTGAAAACCA	0.413000													20	69					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92848455	92848455	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92848455C>T	ENST00000394468.2	-	2	466	c.389G>A	c.(388-390)gGa>gAa	p.G130E	HEPACAM2_ENST00000440868.1_Missense_Mutation_p.G118E|HEPACAM2_ENST00000453812.2_Missense_Mutation_p.G153E|HEPACAM2_ENST00000341723.4_Missense_Mutation_p.G118E	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	130						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						AGATAGAGTTCCATTTCCCTG	0.483000													17	50					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35804209	35804209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35804209G>A	ENST00000392213.3	+	11	1892	c.1733G>A	c.(1732-1734)gGa>gAa	p.G578E	MAG_ENST00000361922.4_3'UTR|MAG_ENST00000537831.2_Missense_Mutation_p.G553E	NM_002361.3	NP_002352.1	P20916	MAG_HUMAN	myelin associated glycoprotein	578					blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			AGGCGCCTGGGATCTGAGAGG	0.622000													16	89					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31774775	31774775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:31774775C>T	ENST00000396556.2	-	6	1191	c.1069G>A	c.(1069-1071)Gaa>Aaa	p.E357K	OSBPL10_ENST00000467647.1_5'UTR|OSBPL10_ENST00000438237.2_Missense_Mutation_p.E293K	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	357					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		GAGGTTTGTTCGTCTTCAGCA	0.453000													26	118					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53908220	53908220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:53908220C>T	ENST00000396328.1	-	15	2422	c.2183G>A	c.(2182-2184)aGa>aAa	p.R728K	WDR72_ENST00000559418.1_Missense_Mutation_p.R738K|WDR72_ENST00000360509.5_Missense_Mutation_p.R728K|WDR72_ENST00000557913.1_Missense_Mutation_p.R725K	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	728										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTTACTTTTTCTCAGTGTCAG	0.468000													26	80					0	0	1	0	0
FGD4	121512	broad.mit.edu	37	12	32760940	32760940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32760940C>T	ENST00000427716.2	+	8	1467	c.1043C>T	c.(1042-1044)cCt>cTt	p.P348L	FGD4_ENST00000534526.2_Missense_Mutation_p.P485L|FGD4_ENST00000381025.3_Missense_Mutation_p.P100L|FGD4_ENST00000531134.1_Missense_Mutation_p.P433L|FGD4_ENST00000546442.1_Missense_Mutation_p.P255L|FGD4_ENST00000525053.1_Missense_Mutation_p.P460L|FGD4_ENST00000266482.3_Missense_Mutation_p.P100L	NM_139241.2	NP_640334.2	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	348	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	27	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					ATGCTAGAACCTGTTCAGCGG	0.393000													61	131					0	0	1	0	0
DBX1	120237	broad.mit.edu	37	11	20181577	20181577	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20181577G>A	ENST00000524983.2	-	1	582	c.294C>T	c.(292-294)gcC>gcT	p.A98A	DBX1_ENST00000227256.3_Silent_p.A98A			A6NMT0	DBX1_HUMAN	developing brain homeobox 1	98					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)	21						CAGGGGAGAAGGCAGTCGGCG	0.706000													5	8					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690158	33690158	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:33690158G>A	ENST00000394566.1	-	4	941	c.669C>T	c.(667-669)ttC>ttT	p.F223F	SLFN11_ENST00000308377.4_Silent_p.F223F	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	223						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CATATTCTTGGAAGTGTTTTG	0.378000													24	128					0	0	1	0	0
MICU3	286097	broad.mit.edu	37	8	16961987	16961987	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:16961987G>A	ENST00000318063.5	+	10	1114	c.1072G>A	c.(1072-1074)Gaa>Aaa	p.E358K	MICU3_ENST00000519866.1_3'UTR	NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		GCTCAACTTTGAAGATTTTTA	0.294000													33	68					0	0	1	0	0
DYNAP	284254	broad.mit.edu	37	18	52262300	52262300	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52262300C>T	ENST00000321600.1	+	2	312	c.266C>T	c.(265-267)tCa>tTa	p.S89L	DYNAP_ENST00000585973.1_Intron	NM_173629.1	NP_775900.1			dynactin associated protein																		CTTGCACATTCAAGATGTCTA	0.448000													55	69					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282402	152282402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152282402C>T	ENST00000368799.1	-	3	4995	c.4960G>A	c.(4960-4962)Ggc>Agc	p.G1654S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1654	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACGAGTGCCTGATTGTCTG	0.562000									Ichthyosis				145	398					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299276	58299276	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58299276G>A	ENST00000377918.3	+	4	3354	c.3328G>A	c.(3328-3330)Gat>Aat	p.D1110N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1110					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGCCAGCCGGGATTCCAGTGA	0.517000													53	168					0	0	1	0	0
TATDN2	9797	broad.mit.edu	37	3	10290984	10290984	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10290984C>T	ENST00000287652.4	+	2	1151	c.100C>T	c.(100-102)Ccc>Tcc	p.P34S	TATDN2_ENST00000448281.2_Missense_Mutation_p.P34S	NM_014760.3	NP_055575.3	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	34						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(9)|pancreas(2)|prostate(1)|stomach(2)	28						TGATGTGGCCCCCTCCAGCCG	0.682000													36	69					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85327597	85327597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:85327597C>T	ENST00000299927.3	+	1	1713	c.1691C>T	c.(1690-1692)cCc>cTc	p.P564L	ZNF592_ENST00000560079.2_Missense_Mutation_p.P564L			Q92610	ZN592_HUMAN	zinc finger protein 592	564					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCTCCAACCCCGTGCCCCTC	0.597000													52	186					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126715450	126715450	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:126715450G>A	ENST00000309035.6	-	1	1009	c.879C>T	c.(877-879)ttC>ttT	p.F293F	CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000411419.2_Intron|CTBP2_ENST00000337195.5_Intron|CTBP2_ENST00000494626.2_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		GAAAGGCCAGGAACTCAGGGA	0.647000													5	53					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31710235	31710235	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:31710235G>A	ENST00000396556.2	-	10	2117	c.1995C>T	c.(1993-1995)ttC>ttT	p.F665F	OSBPL10_ENST00000438237.2_Silent_p.F601F	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	665					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		TGTTGTAGGTGAACTCTAAAG	0.458000													50	101					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6468113	6468113	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6468113C>T	ENST00000381480.2	-	23	1920	c.1808G>A	c.(1807-1809)tGg>tAg	p.W603*	DENND1C_ENST00000543576.1_Nonsense_Mutation_p.W559*	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	603						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						GTCTGGTTGCCATCTTGGTAT	0.537000													13	25					0	0	1	0	0
CPVL	54504	broad.mit.edu	37	7	29132281	29132281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:29132281C>T	ENST00000409850.1	-	10	1146	c.500G>A	c.(499-501)gGa>gAa	p.G167E	CPVL_ENST00000396276.3_Missense_Mutation_p.G167E|CPVL_ENST00000265394.5_Missense_Mutation_p.G167E			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	167					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						GACTGCATATCCGTGGGTATC	0.438000													10	55					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120371457	120371457	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120371457C>T	ENST00000283871.5	-	5	783	c.324G>A	c.(322-324)aaG>aaA	p.K108K		NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	108					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		AGTCTACTTTCTTCTGAGATG	0.428000													11	46					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940807	113940807	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:113940807G>A	ENST00000245796.6	+	2	969	c.774G>A	c.(772-774)gaG>gaA	p.E258E	PSD4_ENST00000441564.2_Silent_p.E258E	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	258					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity	p.E258E(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTTGCTCAGAGAACAGTGCTT	0.607000													28	65					0	0	1	0	0
LTF	4057	broad.mit.edu	37	3	46497370	46497370	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46497370G>A	ENST00000231751.4	-	4	710	c.415C>T	c.(415-417)Cgc>Tgc	p.R139C	LTF_ENST00000417439.1_Missense_Mutation_p.R139C|LTF_ENST00000426532.2_Missense_Mutation_p.R95C	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	139	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	GCGGTCCTGCGAAGGCCTGTG	0.562000													13	39					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370636	240370636	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240370636G>A	ENST00000319653.9	+	5	2754	c.2524G>A	c.(2524-2526)Gaa>Aaa	p.E842K		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	842	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.E985K(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AACCAGCCACGAACACTCTGT	0.557000													27	90					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70953127	70953127	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70953127C>T	ENST00000334414.6	-	18	4754	c.4710G>A	c.(4708-4710)agG>agA	p.R1570R	PTPRB_ENST00000550857.1_Silent_p.R1262R|PTPRB_ENST00000451516.2_Silent_p.R1262R|PTPRB_ENST00000551525.1_Silent_p.R1569R|PTPRB_ENST00000550358.1_Silent_p.R1482R|PTPRB_ENST00000538708.1_Silent_p.R1262R|PTPRB_ENST00000261266.5_Silent_p.R1352R	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1352					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCATACTTGTCCTCACAGATC	0.378000													62	123					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76790610	76790610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:76790610C>T	ENST00000287239.4	+	18	6517	c.6028C>T	c.(6028-6030)Cat>Tat	p.H2010Y	KAT6B_ENST00000372714.1_Missense_Mutation_p.H1718Y|KAT6B_ENST00000372725.1_Missense_Mutation_p.H1718Y|KAT6B_ENST00000372724.1_Missense_Mutation_p.H1718Y|KAT6B_ENST00000372711.1_Missense_Mutation_p.H1827Y	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	2010	Interaction with RUNX1 and RUNX2.|Met-rich.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CCACAGCAATCATGGCTATAT	0.507000													11	142					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475258	140475258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140475258G>A	ENST00000194155.4	+	1	1032	c.884G>A	c.(883-885)cGa>cAa	p.R295Q		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		295	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAACGTTTCGATTAAGTGCA	0.428000													10	103					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798442	55798442	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55798442C>T	ENST00000313555.1	+	1	548	c.548C>T	c.(547-549)cCt>cTt	p.P183L		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					GATATCCCACCTCTTCTGGCT	0.423000													84	300					0	0	1	0	0
LIN54	132660	broad.mit.edu	37	4	83905984	83905984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:83905984G>A	ENST00000340417.3	-	2	391	c.14C>T	c.(13-15)cCa>cTa	p.P5L	LIN54_ENST00000442461.2_Missense_Mutation_p.P5L|LIN54_ENST00000395282.2_Missense_Mutation_p.P5L|LIN54_ENST00000506560.1_Missense_Mutation_p.P5L|LIN54_ENST00000505397.1_Missense_Mutation_p.P5L|LIN54_ENST00000446851.2_Missense_Mutation_p.P5L|LIN54_ENST00000510557.1_Missense_Mutation_p.P5L|LIN54_ENST00000395283.2_Missense_Mutation_p.P5L	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	5					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				CACCTCAGCTGGCACCACCTC	0.383000													24	126					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159170684	159170684	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159170684G>A	ENST00000368125.4	+	9	1326	c.1169G>A	c.(1168-1170)gGg>gAg	p.G390E	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000368124.4_Missense_Mutation_p.G424E|CADM3_ENST00000497636.1_3'UTR	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	390					adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					CAGTCAGGAGGGGACGACAAG	0.612000													17	91					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16411782	16411782	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:16411782C>T	ENST00000334133.4	-	6	1103	c.831G>A	c.(829-831)atG>atA	p.M277I	RFTN1_ENST00000432519.1_Missense_Mutation_p.M241I|RFTN1_ENST00000483671.1_5'UTR	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	277						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						TGAAGATCTCCATTTCTGTTG	0.458000													79	193					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117053514	117053514	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:117053514C>T	ENST00000371876.1	-	3	2808	c.387G>A	c.(385-387)ttG>ttA	p.L129L	KLHL13_ENST00000371882.1_Silent_p.L129L|KLHL13_ENST00000539496.1_Silent_p.L183L|KLHL13_ENST00000262820.3_Silent_p.L180L|KLHL13_ENST00000540167.1_Silent_p.L164L|KLHL13_ENST00000545703.1_Silent_p.L138L|KLHL13_ENST00000541812.1_Silent_p.L164L|KLHL13_ENST00000371878.1_Silent_p.L129L|KLHL13_ENST00000469946.1_Silent_p.L129L			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	180	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						TACAGAAGTCCAAAACTGGCA	0.373000													56	35					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56044681	56044681	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:56044681C>T	ENST00000244728.5	-	3	732	c.335G>A	c.(334-336)gGa>gAa	p.G112E	COL21A1_ENST00000535941.1_Missense_Mutation_p.G112E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G112E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	112	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTTTGTGTTTCCTCCTAAGTA	0.468000													17	34					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28725631	28725631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28725631G>A	ENST00000257197.3	-	7	1143	c.882C>T	c.(880-882)ttC>ttT	p.F294F	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Silent_p.F294F	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	294	Cadherin 2.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GGTGTATGGAGAAATGCTTTG	0.393000													15	153					0	0	1	0	0
OR7E24	26648	broad.mit.edu	37	19	9362178	9362178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9362178C>T	ENST00000456448.1	+	1	573	c.459C>T	c.(457-459)atC>atT	p.I153I		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						ACCGAATCATCATGAACCCAC	0.443000													18	54					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	98006768	98006768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98006768C>T	ENST00000224337.5	-	2	226	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	BLNK_ENST00000413476.2_Missense_Mutation_p.E29K|BLNK_ENST00000495266.1_Missense_Mutation_p.E29K|BLNK_ENST00000427367.2_Missense_Mutation_p.E29K|BLNK_ENST00000371176.2_Missense_Mutation_p.E29K	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	29					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ATTCCACCTTCATTGTTTTTA	0.259000													25	81					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137658856	137658856	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137658856G>A	ENST00000371817.3	+	23	2558	c.2144G>A	c.(2143-2145)gGa>gAa	p.G715E		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	715	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGTCCCCAGGGAGAGCCTGGC	0.647000													5	19					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10742306	10742306	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10742306C>T	ENST00000586078.1	+	8	616	c.507C>T	c.(505-507)gcC>gcT	p.A169A	SLC44A2_ENST00000407327.4_Silent_p.A167A|SLC44A2_ENST00000335757.5_Silent_p.A169A	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	169					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	ATGCAGTGGCCCGGAGATGCT	0.607000													12	24					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032393	142032393	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142032393G>A	ENST00000547918.2	+	0	246																											TCCAAGGCAAGGATGCAGCAG	0.532000													8	26					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81134856	81134856	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:81134856G>A	ENST00000534142.1	-	0	1639				PKD1L2_ENST00000533478.1_RNA|PKD1L2_ENST00000525539.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ATTTTCATCAGCAGCAAATCT	0.522000													15	39					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23886741	23886741	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23886741G>A	ENST00000355349.3	-	31	4486	c.4324C>T	c.(4324-4326)Ctg>Ttg	p.L1442L		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1442					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCTTGTCCAGGGCTGCAGCA	0.612000													42	121					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32752500	32752500	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32752500C>T	ENST00000380250.3	+	21	3104	c.2608C>T	c.(2608-2610)Ccc>Tcc	p.P870S		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CAAGCACTGCCCCACAGCCCT	0.557000													47	137					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77764371	77764371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:77764371G>A	ENST00000354212.4	-	17	3251	c.2998C>T	c.(2998-3000)Ctt>Ttt	p.L1000F	MAGI2_ENST00000419488.1_Missense_Mutation_p.L986F|MAGI2_ENST00000522391.1_Missense_Mutation_p.L1000F	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1000	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GTGACACTAAGACCTGCATCC	0.537000													24	66					0	0	1	0	0
FBXO38	81545	broad.mit.edu	37	5	147803583	147803583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147803583C>T	ENST00000340253.5	+	13	1809	c.1641C>T	c.(1639-1641)atC>atT	p.I547I	FBXO38_ENST00000296701.6_Silent_p.I547I|FBXO38_ENST00000513826.1_Silent_p.I547I|FBXO38_ENST00000394370.3_Silent_p.I547I			Q6PIJ6	FBX38_HUMAN	F-box protein 38	547						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAAGACATCGTCCAAGAAG	0.433000													18	61					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170244629	170244629	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170244629C>T	ENST00000231706.4	-	2	412	c.97G>A	c.(97-99)Gag>Aag	p.E33K	CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	33						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AGCATGGACTCCACTGGTTTG	0.592000													4	29					0	0	1	0	0
C1orf200	644997	broad.mit.edu	37	1	9714487	9714487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9714487G>A	ENST00000377320.3	-	1	157	c.8C>T	c.(7-9)tCc>tTc	p.S3F	PIK3CD_ENST00000377346.4_Intron|PIK3CD_ENST00000536656.1_Intron					chromosome 1 open reading frame 200											endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)	9	all_lung(157;0.222)	Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.86e-08)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(185;0.000231)|KIRC - Kidney renal clear cell carcinoma(229;0.000879)|BRCA - Breast invasive adenocarcinoma(304;0.00178)|STAD - Stomach adenocarcinoma(132;0.00331)|READ - Rectum adenocarcinoma(331;0.0419)		GGCAGACTGGGAGGGCATCAG	0.577000													23	50					0	0	1	0	0
C4orf33	132321	broad.mit.edu	37	4	130023817	130023817	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:130023817C>T	ENST00000281146.4	+	2	773	c.52C>T	c.(52-54)Ccc>Tcc	p.P18S	C4orf33_ENST00000425929.1_Missense_Mutation_p.P18S|C4orf33_ENST00000502887.1_Missense_Mutation_p.P18S	NM_173487.2	NP_775758.2	Q8N1A6	CD033_HUMAN	chromosome 4 open reading frame 33	18										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	10						GAAGCATGAGCCCGTATTTAT	0.398000													20	83					0	0	1	0	0
GPX3	2878	broad.mit.edu	37	5	150407532	150407532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150407532G>A	ENST00000388825.4	+	5	614	c.522G>A	c.(520-522)atG>atA	p.M174I	GPX3_ENST00000517973.1_3'UTR	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	174					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	GGGAACCCATGAAGGTTCACG	0.567000													19	60					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	484775	484775	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:484775C>T	ENST00000264938.3	-	5	801	c.792G>A	c.(790-792)gtG>gtA	p.V264V	SLC9A3_ENST00000514375.1_Silent_p.V264V	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	264						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGACCACCCCCACCAGCGTGC	0.647000													29	66					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182597411	182597411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:182597411C>T	ENST00000323116.5	+	20	2640	c.2380C>T	c.(2380-2382)Cgt>Tgt	p.R794C		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	794					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			ATTATGCTGTCGTATGGCTCC	0.358000													17	104					0	0	1	0	0
ZSCAN23	222696	broad.mit.edu	37	6	28403867	28403867	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28403867G>A	ENST00000289788.4	-	2	322	c.177C>T	c.(175-177)tcC>tcT	p.S59S	ZSCAN23_ENST00000486481.1_Intron	NM_001012455.1	NP_001012458.1	Q3MJ62	ZSC23_HUMAN	zinc finger and SCAN domain containing 23	59	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|prostate(1)|stomach(2)	4						GGGGCCCAGGGGACTCCTGAT	0.552000													19	41					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123887120	123887120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123887120C>T	ENST00000320891.4	+	1	839	c.839C>T	c.(838-840)cCc>cTc	p.P280L		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGCTGACGCCCCTTCTCAAC	0.463000													22	89					0	0	1	0	0
NFIA	4774	broad.mit.edu	37	1	61553906	61553906	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:61553906G>A	ENST00000403491.3	+	2	597	c.113G>A	c.(112-114)cGa>cAa	p.R38Q	NFIA_ENST00000371184.2_Missense_Mutation_p.R38Q|NFIA_ENST00000371187.3_Missense_Mutation_p.R38Q|NFIA_ENST00000371191.1_Missense_Mutation_p.R61Q|NFIA_ENST00000485903.2_Missense_Mutation_p.R38Q|NFIA_ENST00000371185.2_Missense_Mutation_p.R38Q|NFIA_ENST00000371189.4_Missense_Mutation_p.R83Q|NFIA_ENST00000479364.1_Intron|NFIA_ENST00000407417.3_Missense_Mutation_p.R30Q	NM_001134673.3|NM_005595.4	NP_001128145.1|NP_005586.1	Q12857	NFIA_HUMAN	nuclear factor I/A	38					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding		NFIA/EHF(2)	endometrium(1)|kidney(2)|large_intestine(8)|lung(20)|pancreas(1)|prostate(1)|skin(1)	34						GCCCGAAAACGAAAATACTTC	0.438000													33	172					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38949934	38949934	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38949934G>A	ENST00000355481.4	+	19	2447	c.2316G>A	c.(2314-2316)ctG>ctA	p.L772L	RYR1_ENST00000360985.3_Silent_p.L772L|RYR1_ENST00000359596.3_Silent_p.L772L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	772	B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCTTCAACCTGGACGGGCTCT	0.602000													14	46					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29044306	29044306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29044306C>T	ENST00000257189.4	+	9	1315	c.1232C>T	c.(1231-1233)gCc>gTc	p.A411V		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	411	Cadherin 4.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACATATCAAGCCATCGATGAG	0.358000													20	70					0	0	1	0	0
C1orf141	400757	broad.mit.edu	37	1	67560983	67560983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:67560983C>T	ENST00000371007.2	-	7	647	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K	C1orf141_ENST00000371006.1_Missense_Mutation_p.E180K|C1orf141_ENST00000544837.1_Missense_Mutation_p.E180K	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	180										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						TTTTTCAATTCATCCTCAAAG	0.323000													15	38					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32689700	32689700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:32689700C>T	ENST00000421745.2	+	25	5199	c.5065C>T	c.(5065-5067)Cat>Tat	p.H1689Y		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1689					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					ATTCTTCATTCATCCATCTGA	0.488000													12	35					0	0	1	0	0
MAPK6	5597	broad.mit.edu	37	15	52356461	52356461	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52356461C>T	ENST00000261845.5	+	6	2237	c.1430C>T	c.(1429-1431)tCc>tTc	p.S477F	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	477					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		ATAGATCTTTCCAATTGGAAA	0.348000													9	35					0	0	1	0	0
ALDOB	229	broad.mit.edu	37	9	104184165	104184165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104184165C>T	ENST00000374855.4	-	9	1145	c.1021G>A	c.(1021-1023)Gga>Aga	p.G341R		NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	341					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				ACATACTGTCCTTTGGCCGCC	0.542000													8	52					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891226	18891226	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18891226G>A	ENST00000317658.3	+	1	182	c.24G>A	c.(22-24)agG>agA	p.R8R		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	8					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				TGCTGAGCAGGAAGGACAAGG	0.433000													25	75					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160708785	160708785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160708785G>A	ENST00000263636.4	-	21	2837	c.2810C>T	c.(2809-2811)tCg>tTg	p.S937L	LY75-CD302_ENST00000505052.1_Missense_Mutation_p.S937L|LY75_ENST00000553424.1_Missense_Mutation_p.S937L|LY75_ENST00000554112.1_Missense_Mutation_p.S937L|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.S937L	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TTTCTCTAACGAAGAAACATT	0.373000													23	84					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177247706	177247706	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177247706C>T	ENST00000361539.4	+	7	1332	c.1020C>T	c.(1018-1020)ttC>ttT	p.F340F	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		340						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CAGAAGAGTTCCAGGCCCTGC	0.587000													37	275					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3614464	3614464	+	RNA	SNP	G	G	A	rs150523532	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3614464G>A	ENST00000301749.7	-	0	879				NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000324659.8_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGAGGCGGACGAAGTGCCTCA	0.657000													10	32					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65253698	65253698	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65253698C>T	ENST00000389722.3	-	15	3038	c.2985G>A	c.(2983-2985)agG>agA	p.R995R	SPTB_ENST00000389720.3_Silent_p.R995R|SPTB_ENST00000389721.5_Silent_p.R995R|SPTB_ENST00000556626.1_Silent_p.R995R|SPTB_ENST00000542895.1_Silent_p.R995R	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	995					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton	p.R995R(1)		breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTGACAACTTCCTCTGGATGG	0.607000													20	39					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56087734	56087734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56087734C>T	ENST00000429804.2	-	7	1815	c.1255G>A	c.(1255-1257)Gaa>Aaa	p.E419K	CTCFL_ENST00000426658.2_3'UTR|CTCFL_ENST00000422869.2_Missense_Mutation_p.E469K|CTCFL_ENST00000422109.2_Intron|CTCFL_ENST00000423479.2_Missense_Mutation_p.E469K|CTCFL_ENST00000371196.2_Missense_Mutation_p.E469K|CTCFL_ENST00000243914.3_Missense_Mutation_p.E469K|CTCFL_ENST00000539382.1_Missense_Mutation_p.E264K|CTCFL_ENST00000432255.2_Intron|CTCFL_ENST00000433949.2_Missense_Mutation_p.E469K|CTCFL_ENST00000502686.2_Missense_Mutation_p.E207K	NM_001269046.1	NP_001255975.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	469					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			GCATAGCGTTCATGGAAGACA	0.443000													22	48					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45472270	45472270	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45472270C>T	ENST00000291574.4	+	4	570	c.395C>T	c.(394-396)gCc>gTc	p.A132V	TRAPPC10_ENST00000380221.3_Missense_Mutation_p.A132V	NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	132					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						GAAAATGATGCCAAGAAAAAA	0.368000													29	119					0	0	1	0	0
MXRA8	54587	broad.mit.edu	37	1	1290374	1290374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1290374C>T	ENST00000309212.6	-	5	667	c.637G>A	c.(637-639)Ggg>Agg	p.G213R	MXRA8_ENST00000445648.2_Missense_Mutation_p.G213R|MXRA8_ENST00000342753.4_Missense_Mutation_p.G112R	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	213	Ig-like V-type 2.					integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGCGGGACCCCGGGCGGCTGC	0.741000													5	7					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179736188	179736188	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179736188C>T	ENST00000420890.2	-	14	2288	c.2171G>A	c.(2170-2172)cGa>cAa	p.R724Q	CCDC141_ENST00000295723.5_Missense_Mutation_p.R149Q	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	149							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCATTTTTGTCGTAGATCTAA	0.393000													74	157					0	0	1	0	0
GHRHR	2692	broad.mit.edu	37	7	31013635	31013635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31013635C>T	ENST00000409904.3	+	4	699	c.441C>T	c.(439-441)ttC>ttT	p.F147F	GHRHR_ENST00000326139.2_Silent_p.F211F|GHRHR_ENST00000409316.1_Intron|GHRHR_ENST00000461424.1_3'UTR			Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	211					activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			biliary_tract(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35					Sermorelin(DB00010)	CCTCCCATTTCGCCACCATGA	0.627000													19	78					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186541233	186541233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186541233C>T	ENST00000431808.1	-	15	3139	c.2576G>A	c.(2575-2577)gGa>gAa	p.G859E	SORBS2_ENST00000498125.1_5'UTR|SORBS2_ENST00000448662.2_Missense_Mutation_p.G420E|SORBS2_ENST00000449407.2_Missense_Mutation_p.G403E|SORBS2_ENST00000437304.2_Missense_Mutation_p.G583E|SORBS2_ENST00000418609.1_Missense_Mutation_p.G763E|SORBS2_ENST00000393528.3_Missense_Mutation_p.G425E|SORBS2_ENST00000355634.5_Missense_Mutation_p.G959E|SORBS2_ENST00000284776.7_Missense_Mutation_p.G859E|SORBS2_ENST00000319471.9_Missense_Mutation_p.G490E			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	859						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TTCTGGAGTTCCTCTTCTTTC	0.438000													94	232					0	0	1	0	0
OR6B2	389090	broad.mit.edu	37	2	240969788	240969788	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:240969788G>A	ENST00000402971.2	-	1	118	c.59C>T	c.(58-60)gCc>gTc	p.A20V		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		CAGCCCTGGGGCCGTGGGGAG	0.582000													6	58					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74540379	74540379	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:74540379C>T	ENST00000354431.4	-	6	1154	c.963G>A	c.(961-963)atG>atA	p.M321I	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.M321I	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	321										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTTTTGATTTCATGCCTAGAT	0.224000													8	13					0	0	1	0	0
PARP3	10039	broad.mit.edu	37	3	51979178	51979178	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51979178C>T	ENST00000417220.2	+	7	1287	c.799C>T	c.(799-801)Cac>Tac	p.H267Y	PARP3_ENST00000431474.1_Missense_Mutation_p.H267Y|PARP3_ENST00000398755.3_Missense_Mutation_p.H274Y			Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	267	PARP alpha-helical.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CAACTTCGGCCACAGCCAGCC	0.652000													44	114					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350329	100350329	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100350329C>T	ENST00000542585.1	+	0	2749				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCACCATCTCCCCAGAAAAAC	0.483000													42	116					0	0	1	0	0
PNPT1	87178	broad.mit.edu	37	2	55894164	55894164	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:55894164G>C	ENST00000447944.2	-	13	1224	c.1138C>G	c.(1138-1140)Ctt>Gtt	p.L380V		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	380					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GATCCATGAAGGGTTTTAAAC	0.308000													16	39					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94668201	94668201	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94668201G>A	ENST00000260526.6	-	11	1224	c.1042C>T	c.(1042-1044)Cgt>Tgt	p.R348C	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.R348C	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	348					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TCTTCTGCACGAAACATGGAA	0.408000													54	141					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70500887	70500887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:70500887C>T	ENST00000428974.2	+	5	521	c.463C>T	c.(463-465)Cct>Tct	p.P155S	FUK_ENST00000571514.1_Intron|FUK_ENST00000288078.6_Intron|FUK_ENST00000378912.2_Intron			Q8N0W3	FUK_HUMAN	fucokinase	611						cytoplasm	ATP binding|fucokinase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				GGACTGCCTTCCTTCGTCACA	0.647000													11	30					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89924433	89924433	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89924433G>A	ENST00000405460.2	+	8	1389	c.1293G>A	c.(1291-1293)gcG>gcA	p.A431A		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	431					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGTCTCTGCGAATTGGGTGT	0.418000													20	69					0	0	1	0	0
ATP6V0E2	155066	broad.mit.edu	37	7	149576474	149576474	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149576474C>T	ENST00000421974.2	+	3	1301	c.350C>T	c.(349-351)tCg>tTg	p.S117L	ATP6V0E2_ENST00000479613.1_Missense_Mutation_p.S91L|ATP6V0E2_ENST00000495408.1_3'UTR|ATP6V0E2_ENST00000456496.2_3'UTR|ATP6V0E2_ENST00000425642.2_3'UTR|ATP6V0E2_ENST00000606024.1_Missense_Mutation_p.S68L	NM_001100592.1	NP_001094062.1	Q8NHE4	VA0E2_HUMAN	ATPase, H+ transporting V0 subunit e2	63					ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuole	ATPase activity, coupled to transmembrane movement of ions|hydrogen ion transmembrane transporter activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00256)			ACAACCCCTTCGTCCGGACCC	0.622000													9	17					0	0	1	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545613	234545613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:234545613C>T	ENST00000344644.5	+	1	514	c.445C>T	c.(445-447)Cct>Tct	p.P149S	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Missense_Mutation_p.P149S	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTTTCTGGATCCTTTTGATAC	0.383000													72	144					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47506911	47506911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47506911G>A	ENST00000285039.7	-	9	1258	c.959C>T	c.(958-960)tCc>tTc	p.S320F		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	320	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CATCTGATGGGACTCTTTCAC	0.393000													12	48					0	0	1	0	0
TMEM201	199953	broad.mit.edu	37	1	9661297	9661297	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9661297C>T	ENST00000340305.5	+	5	750	c.741C>T	c.(739-741)ccC>ccT	p.P247P	TMEM201_ENST00000340381.6_Silent_p.P247P|TMEM201_ENST00000377376.4_Silent_p.P247P	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	247						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		CCACTGTGCCCCTGGCCCTGC	0.692000													8	91					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17444716	17444716	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17444716G>A	ENST00000400588.1	-	9	1587	c.1480C>T	c.(1480-1482)Ccg>Tcg	p.P494S		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	494										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCAGATGCCGGGTTCTGCTGT	0.592000													15	44					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74976528	74976528	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:74976528G>A	ENST00000261978.4	-	21	3572	c.3186C>T	c.(3184-3186)ccC>ccT	p.P1062P	LTBP2_ENST00000556690.1_Silent_p.P1062P	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1062	Cys-rich.|EGF-like 9; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGAGGCCTGTGGGGCATGAGG	0.592000													12	145					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	166958581	166958581	+	Nonstop_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:166958581T>A	ENST00000392766.2	-	21	2743	c.2403A>T	c.(2401-2403)taA>taT	p.*801Y	ZBBX_ENST00000307529.5_Nonstop_Mutation_p.*840Y|ZBBX_ENST00000392764.1_Nonstop_Mutation_p.*772Y|ZBBX_ENST00000392767.2_Nonstop_Mutation_p.*801Y|ZBBX_ENST00000455345.2_Nonstop_Mutation_p.*840Y	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	0						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CAAATAATCTTTAAGTACTCT	0.388000													34	90					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21309123	21309123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21309123G>A	ENST00000417816.2	-	3	525	c.172C>T	c.(172-174)Ccg>Tcg	p.P58S	NEBL_ENST00000377159.4_Missense_Mutation_p.P24S	NM_001173484.1|NM_213569.2	NP_001166955.1|NP_998734.1	O76041	NEBL_HUMAN	nebulette	720				RYKEEFKK -> VIKKSLKS (in Ref. 2; AAF24858).	regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GACTGCTTCGGGTAGTGTCTG	0.413000													8	104					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154861319	154861319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:154861319C>T	ENST00000460393.1	+	13	1396	c.1276C>T	c.(1276-1278)Ctt>Ttt	p.L426F	MME_ENST00000360490.2_Missense_Mutation_p.L426F|MME_ENST00000462745.1_Missense_Mutation_p.L426F|MME_ENST00000492661.1_Missense_Mutation_p.L426F|MME_ENST00000493237.1_Missense_Mutation_p.L426F	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	426					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TGTGGGGAGGCTTTATGTGGA	0.413000													55	142					0	0	1	0	0
ARMC4P1	101060171	broad.mit.edu	37	10	27552006	27552006	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27552006G>A	ENST00000576034.1	+	0	262																											CCCTCTAAATGAAGTGATATT	0.438000													20	39					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29420417	29420417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29420417G>A	ENST00000389048.3	-	27	4970	c.4064C>T	c.(4063-4065)cCt>cTt	p.P1355L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1355	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CACAGGCCCAGGGCAGTTCTT	0.438000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome		OREG0014526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	82					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70144128	70144128	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:70144128C>T	ENST00000370958.1	+	2	257	c.67C>T	c.(67-69)Cgt>Tgt	p.R23C	LRRC7_ENST00000310961.5_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	0						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TAAAGAGGTTCGTGCAGCACT	0.403000													8	10					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501770	140501770	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140501770C>A	ENST00000194152.1	+	1	190	c.190C>A	c.(190-192)Cgg>Agg	p.R64R		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		64	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGTCAGCCCGGGTGCTGTC	0.567000													22	68					7.41877e-09	7.44533e-09	1	1	0
LY86	9450	broad.mit.edu	37	6	6649878	6649878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:6649878C>T	ENST00000379953.2	+	5	725	c.373C>T	c.(373-375)Cct>Tct	p.P125S	LY86_ENST00000230568.4_Missense_Mutation_p.P125S			O95711	LY86_HUMAN	lymphocyte antigen 86	125					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane				large_intestine(2)|lung(6)	8	Ovarian(93;0.0377)					CTATGCTGGGCCTGTCAATAA	0.299000													28	57					0	0	1	0	0
STAU1	6780	broad.mit.edu	37	20	47752396	47752396	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47752396T>C	ENST00000371828.3	-	6	827	c.340A>G	c.(340-342)Aaa>Gaa	p.K114E	STAU1_ENST00000371856.2_Missense_Mutation_p.K195E|STAU1_ENST00000340954.7_Missense_Mutation_p.K114E|STAU1_ENST00000371802.1_Missense_Mutation_p.K114E|STAU1_ENST00000347458.5_Missense_Mutation_p.K114E|STAU1_ENST00000360426.4_Missense_Mutation_p.K114E|STAU1_ENST00000371792.1_Missense_Mutation_p.K114E	NM_001037328.1|NM_004602.2	NP_001032405.1|NP_004593.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	195	DRBM 1.					microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			AAGTTCCGTTTAAGTGCAATC	0.328000													20	50					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47976805	47976805	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47976805C>T	ENST00000543600.1	-	2	460	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	PTCHD4_ENST00000339488.4_Missense_Mutation_p.E158K			Q6ZW05	CF138_HUMAN	patched domain containing 4	158						integral to membrane	hedgehog receptor activity										TTTGGCACTTCCACTACCCCG	0.483000													10	28					0	0	1	0	0
GCA	25801	broad.mit.edu	37	2	163213409	163213409	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163213409C>T	ENST00000437150.2	+	5	609	c.448C>T	c.(448-450)Ctt>Ttt	p.L150F	GCA_ENST00000233612.4_Missense_Mutation_p.L131F|GCA_ENST00000429691.2_Intron	NM_012198.3	NP_036330.1	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	150	EF-hand 3.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	9						AGCCATTGGTCTTATGGGTAA	0.363000													6	96					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51863539	51863539	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:51863539G>A	ENST00000453097.2	+	12	1708	c.1491G>A	c.(1489-1491)ggG>ggA	p.G497G	SLC4A8_ENST00000394856.1_Silent_p.G444G|SLC4A8_ENST00000514353.3_Silent_p.G444G|SLC4A8_ENST00000546663.1_3'UTR|SLC4A8_ENST00000358657.3_Silent_p.G524G|SLC4A8_ENST00000535225.2_Silent_p.G444G	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	497					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		TCACCTTTGGGGGACTGCTTG	0.502000													15	104					0	0	1	0	0
KDM7A	80853	broad.mit.edu	37	7	139801824	139801824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139801824G>A	ENST00000397560.2	-	12	1662	c.1565C>T	c.(1564-1566)cCt>cTt	p.P522L	JHDM1D_ENST00000006967.5_Missense_Mutation_p.P522L	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		522					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					TAGGTTAGAAGGAGTTCGGAC	0.433000													38	165					0	0	1	0	0
PROCR	10544	broad.mit.edu	37	20	33764245	33764245	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33764245G>A	ENST00000216968.4	+	3	679	c.597G>A	c.(595-597)acG>acA	p.T199T	EDEM2_ENST00000540582.1_Intron	NM_006404.3	NP_006395.2	Q9UNN8	EPCR_HUMAN	protein C receptor, endothelial	199					antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity			breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	CGGAAAACACGAAAGGTATGA	0.547000													28	70					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126242399	126242399	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126242399G>A	ENST00000394329.3	+	1	4846	c.4833G>A	c.(4831-4833)agG>agA	p.R1611R		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1611	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CTGAAAGGAGGAAATCGACCA	0.438000													42	122					0	0	1	0	0
CDC42EP4	23580	broad.mit.edu	37	17	71281633	71281633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:71281633G>A	ENST00000335793.3	-	2	1401	c.1007C>T	c.(1006-1008)tCa>tTa	p.S336L	CDC42EP4_ENST00000581014.1_Silent_p.L68L|CDC42EP4_ENST00000439510.2_Missense_Mutation_p.S266L			Q9H3Q1	BORG4_HUMAN	CDC42 effector protein (Rho GTPase binding) 4	336					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(7)|urinary_tract(1)	14			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			TGGCTGTCTTGAGACAGCAGC	0.647000													33	63					0	0	1	0	0
DENND2D	79961	broad.mit.edu	37	1	111741362	111741362	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111741362C>T	ENST00000357640.4	-	3	475	c.246G>A	c.(244-246)cgG>cgA	p.R82R	DENND2D_ENST00000369752.5_Silent_p.R79R|DENND2D_ENST00000473682.1_5'UTR	NM_024901.3	NP_079177.2	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	82	UDENN.									breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		GCAGGTTCTCCCGCTATAAGG	0.557000													13	43					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91755509	91755509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91755509G>A	ENST00000389857.6	-	25	4467	c.4381C>T	c.(4381-4383)Ccc>Tcc	p.P1461S		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1461					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CCCAGTGCGGGGGTGTCGGGG	0.697000													29	54					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28229561	28229561	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28229561C>T	ENST00000305242.5	-	13	2009	c.1917G>A	c.(1915-1917)cgG>cgA	p.R639R	ARMC4_ENST00000537576.1_Silent_p.R331R|ARMC4_ENST00000545014.1_Silent_p.R164R	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	639							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TCTTCAGCAGCCGAGCCAACA	0.527000													44	112					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141315179	141315179	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141315179C>T	ENST00000325617.5	-	11	1606	c.1166G>A	c.(1165-1167)cGa>cAa	p.R389Q	CLGN_ENST00000414773.1_Missense_Mutation_p.R389Q|CLGN_ENST00000537281.1_Missense_Mutation_p.R389Q	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	389					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					AGGAATTTTTCGAGGACTCCA	0.343000													18	47					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86947982	86947982	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86947982C>T	ENST00000234701.3	+	6	1003	c.652C>T	c.(652-654)Ctc>Ttc	p.L218F	CLCA1_ENST00000394711.1_Missense_Mutation_p.L218F			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	218					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		AGTAACAGGACTCTATGAAAA	0.403000													5	87					0	0	1	0	0
RBMY2EP	159125	broad.mit.edu	37	Y	23557655	23557655	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:23557655C>T	ENST00000444169.1	-	0	320					NR_001574.2																						CCACGGGTTTCGTCGTAGCCA	0.299000													6	2					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14157366	14157366	+	Silent	SNP	G	G	A	rs140727303		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:14157366G>A	ENST00000263379.2	+	8	1202	c.1077G>A	c.(1075-1077)ggG>ggA	p.G359G		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	359	Fibronectin type-III 2.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						CTCGAGATGGGGACCCCCTGG	0.642000													31	100					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64428396	64428396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64428396C>T	ENST00000265459.6	-	10	2475	c.2014G>A	c.(2014-2016)Ggc>Agc	p.G672S	NRXN2_ENST00000496291.1_5'UTR|NRXN2_ENST00000377559.3_Missense_Mutation_p.G641S|NRXN2_ENST00000409571.1_Missense_Mutation_p.G665S|NRXN2_ENST00000377551.1_Missense_Mutation_p.G672S	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	672	Laminin G-like 3.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TCAGCCAGGCCCCGGAGGTCT	0.682000													23	33					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152586	18152586	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18152586C>T	ENST00000375406.1	+	3	889	c.673C>T	c.(673-675)Cgt>Tgt	p.R225C		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	225						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CCTGGACTTTCGTGAGAGGCA	0.597000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	75					0	0	1	0	0
FAXC	84553	broad.mit.edu	37	6	99797051	99797051	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:99797051G>A	ENST00000389677.5	-	1	480	c.198C>T	c.(196-198)acC>acT	p.T66T		NM_032511.2	NP_115900.1	Q5TGI0	CF168_HUMAN	failed axon connections homolog (Drosophila)	66																	TCAAGTAAAGGGTTTTCTTCC	0.597000													26	46					0	0	1	0	0
POLI	11201	broad.mit.edu	37	18	51818291	51818291	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:51818291C>T	ENST00000579534.1	+	9	1430	c.1287C>T	c.(1285-1287)acC>acT	p.T429T	POLI_ENST00000406285.3_Silent_p.T350T|POLI_ENST00000217800.5_Silent_p.T303T|POLI_ENST00000582366.1_3'UTR|POLI_ENST00000579434.1_Silent_p.T326T	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	429					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		TTCACCTTACCCTTCTAAGTG	0.338000								DNA polymerases (catalytic subunits)					17	70					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23517527	23517527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23517527C>T	ENST00000397359.3	-	13	2381	c.2122G>A	c.(2122-2124)Ggg>Agg	p.G708R	CDH24_ENST00000487137.2_Missense_Mutation_p.G670R|CDH24_ENST00000554034.1_Missense_Mutation_p.G670R|CDH24_ENST00000485922.1_5'UTR|CDH24_ENST00000267383.5_Missense_Mutation_p.G708R	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	708					adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		ggggccgccccgTCCGGGTTC	0.761000													45	87					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897363	153897363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:153897363C>T	ENST00000511601.1	+	12	3108	c.2920C>T	c.(2920-2922)Ccc>Tcc	p.P974S	FHDC1_ENST00000260008.3_Missense_Mutation_p.P974S			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	974					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GAGGGACGTTCCCCTGCAGCC	0.662000													16	32					0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54872709	54872709	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54872709G>A	ENST00000391743.3	-	2	404	c.124C>T	c.(124-126)Ctg>Ttg	p.L42L	LAIR1_ENST00000391742.2_Silent_p.L60L|LAIR1_ENST00000434277.2_Silent_p.L59L|LAIR1_ENST00000313038.6_Silent_p.L53L|LAIR1_ENST00000348231.4_Silent_p.L60L|LAIR1_ENST00000463489.1_5'UTR|LAIR1_ENST00000474878.1_Silent_p.L59L			Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like receptor 1	60	Ig-like C2-type.					integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		TCCCTCTCCAGGCGGAATGTT	0.562000													64	150					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54080850	54080850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54080850G>A	ENST00000253144.9	+	7	2369	c.1036G>A	c.(1036-1038)Gag>Aag	p.E346K	ZNF331_ENST00000449416.1_Missense_Mutation_p.E346K|ZNF331_ENST00000513999.1_Missense_Mutation_p.E346K|ZNF331_ENST00000411977.2_Missense_Mutation_p.E346K|ZNF331_ENST00000512387.1_Missense_Mutation_p.E346K|ZNF331_ENST00000511154.1_Missense_Mutation_p.E346K|ZNF331_ENST00000513265.1_3'UTR|ZNF331_ENST00000511593.2_Missense_Mutation_p.E346K	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E346K(1)		NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		CGTTAAGCACGAGAGGATACA	0.527000			T	?	follicular thyroid adenoma								21	51					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40790001	40790001	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40790001C>T	ENST00000373198.3	-	18	2974	c.2739G>A	c.(2737-2739)gaG>gaA	p.E913E	PTPRT_ENST00000373193.3_Silent_p.E894E|PTPRT_ENST00000373184.1_Silent_p.E881E|PTPRT_ENST00000373201.1_Silent_p.E881E|PTPRT_ENST00000373190.1_Silent_p.E890E|PTPRT_ENST00000373187.1_Silent_p.E891E|PTPRT_ENST00000356100.2_Silent_p.E900E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	891	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTCGTATTCCTCCTTGAACC	0.552000													30	61					0	0	1	0	0
ZBTB34	403341	broad.mit.edu	37	9	129641745	129641745	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:129641745C>T	ENST00000319119.4	+	2	152	c.67C>T	c.(67-69)Ctg>Ttg	p.L23L	ZBTB34_ENST00000373452.2_Silent_p.L19L	NM_001099270.1	NP_001092740.1	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12						CAGCACCGTTCTGAGCCAGCT	0.507000													30	97					0	0	1	0	0
TLDC2	140711	broad.mit.edu	37	20	35506399	35506399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35506399C>T	ENST00000217320.3	+	2	175	c.131C>T	c.(130-132)cCc>cTc	p.P44L	TLDC2_ENST00000602922.1_Missense_Mutation_p.P44L	NM_080628.1	NP_542195.1			TBC/LysM-associated domain containing 2																		CCTGAGGATCCCACGGTGCCC	0.607000													21	73					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30605092	30605092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30605092G>A	ENST00000358107.4	-	8	1656	c.1657C>T	c.(1657-1659)Cgt>Tgt	p.R553C	MTPAP_ENST00000263063.3_Missense_Mutation_p.R423C|MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	423					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						CTCAAGTCACGAACAAATGTG	0.343000													12	39					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170198469	170198469	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170198469C>T	ENST00000231706.4	-	7	1917	c.1602G>A	c.(1600-1602)aaG>aaA	p.K534K	CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	534						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CAATCAGCTTCTTTAACTTGA	0.507000													39	100					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207103749	207103749	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207103749C>T	ENST00000356495.4	-	11	2392	c.2209G>A	c.(2209-2211)Gag>Aag	p.E737K		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	737						extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TCGGCTTCCTCCTTGGATGAC	0.627000													8	34					0	0	1	0	0
LOC344967	344967	broad.mit.edu	37	4	40045328	40045328	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40045328C>T	ENST00000381811.2	-	0	821					NR_027277.1																						TGGCCCTCCTCCTCCTGCTCC	0.597000													15	25					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389379	4389379	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4389379G>A	ENST00000408920.2	-	1	237	c.147C>T	c.(145-147)ttC>ttT	p.F49F		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGGATAATGAAGATGAGCA	0.532000													13	28					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121478834	121478834	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121478834G>A	ENST00000260197.7	+	38	5317	c.5188G>A	c.(5188-5190)Gga>Aga	p.G1730R	SORL1_ENST00000534286.1_Missense_Mutation_p.G640R|SORL1_ENST00000525532.1_Missense_Mutation_p.G674R|SORL1_ENST00000532694.1_Missense_Mutation_p.G576R|SORL1_ENST00000527934.1_Missense_Mutation_p.G345R	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1730	Fibronectin type-III 2.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GACTAGTCGTGGAATAGGAAA	0.373000													23	58					0	0	1	0	0
ACTR3	10096	broad.mit.edu	37	2	114670797	114670797	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:114670797C>T	ENST00000536059.1	+	2	263	c.32C>T	c.(31-33)tCc>tTc	p.S11F	ACTR3_ENST00000535589.2_5'UTR|ACTR3_ENST00000263238.2_Silent_p.I31I			P61158	ARP3_HUMAN	ARP3 actin-related protein 3 homolog (yeast)	0					cellular component movement|cilium morphogenesis	Arp2/3 protein complex	actin binding|ATP binding			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(2)	15						AGTTTATCATCCCTTCCTGTA	0.294000													24	71					0	0	1	0	0
ZNF658	26149	broad.mit.edu	37	9	40774551	40774551	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:40774551A>T	ENST00000602553.1	-	5	1018	c.724T>A	c.(724-726)Tcc>Acc	p.S242T	ZNF658_ENST00000441795.1_Missense_Mutation_p.S240T|ZNF658_ENST00000377626.3_Missense_Mutation_p.S242T			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TCCTTACAGGACTTTTCTCCT	0.328000													24	90					0	0	1	0	0
CLCNKA	1187	broad.mit.edu	37	1	16351295	16351295	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16351295C>T	ENST00000375692.1	+	5	395	c.267C>T	c.(265-267)caC>caT	p.H89H	CLCNKA_ENST00000420078.1_Silent_p.H89H|CLCNKA_ENST00000439316.2_Intron|CLCNKA_ENST00000464764.1_Intron|CLCNKA_ENST00000331433.4_Silent_p.H89H			P51800	CLCKA_HUMAN	chloride channel, voltage-sensitive Ka	89					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(1)	19		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GGGACAGCCACCTGCTCCGGT	0.622000													21	52					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97919993	97919993	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:97919993C>T	ENST00000534948.1	+	0	4771							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		AAGGCAAAACCTGAAGATGTC	0.383000													12	24					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127671201	127671201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127671201C>T	ENST00000508053.1	-	35	4767	c.3793G>A	c.(3793-3795)Gaa>Aaa	p.E1265K	FBN2_ENST00000262464.4_Missense_Mutation_p.E1265K|FBN2_ENST00000508989.1_Missense_Mutation_p.E1232K|FBN2_ENST00000507835.1_Missense_Mutation_p.E115K			P35556	FBN2_HUMAN	fibrillin 2	1265	EGF-like 19; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CAGCTGCATTCGTAGCTTCCC	0.433000													70	165					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42583205	42583205	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42583205C>A	ENST00000600245.1	+	2	1102	c.447C>A	c.(445-447)ctC>ctA	p.L149L	CTB-59C6.3_ENST00000594531.1_RNA|ZNF574_ENST00000222339.7_Silent_p.L239L|ZNF574_ENST00000359044.4_Silent_p.L149L			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				AGACGCACCTCCGGGCCACAC	0.642000													47	77					6.23363e-37	6.27865e-37	1	1	0
C6	729	broad.mit.edu	37	5	41203238	41203238	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41203238C>T	ENST00000263413.3	-	2	359	c.95G>A	c.(94-96)tGg>tAg	p.W32*	C6_ENST00000337836.5_Nonsense_Mutation_p.W32*	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	32	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCAGCTGGTCCACTGAGTCCA	0.507000													22	244					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934633	28934633	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28934633C>T	ENST00000257192.4	+	15	2686	c.2474C>T	c.(2473-2475)cCt>cTt	p.P825L	DSG1_ENST00000462981.2_Missense_Mutation_p.P184L|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	825					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CATCCTAAGCCTATTCTCGAT	0.517000													67	164					0	0	1	0	0
PNMT	5409	broad.mit.edu	37	17	37826205	37826205	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37826205G>A	ENST00000269582.2	+	3	730	c.410_splice	c.e3-1	p.E138_splice	PNMT_ENST00000581428.1_3'UTR|PNMT_ENST00000394246.1_Splice_Site_p.E40_splice	NM_002686.3	NP_002677.1	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	138					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			NS(1)|breast(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCTGCACAGGGAATGCTGGCA	0.652000													8	51					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123019002	123019002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123019002G>A	ENST00000462833.1	-	15	4077	c.2865C>T	c.(2863-2865)ttC>ttT	p.F955F	ADCY5_ENST00000491190.1_Silent_p.F588F|ADCY5_ENST00000309879.5_Silent_p.F605F	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	955					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CGGCGTTGTCGAAGAGCGTGA	0.617000													14	52					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20443765	20443765	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20443765C>T	ENST00000305051.5	+	1	163	c.88C>T	c.(88-90)Cat>Tat	p.H30Y		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGAGACAAATCATTCTCGGGT	0.388000													56	107					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69816835	69816835	+	Missense_Mutation	SNP	G	G	A	rs138523993		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69816835G>A	ENST00000251566.4	-	1	674	c.644C>T	c.(643-645)tCa>tTa	p.S215L	UGT2A3_ENST00000420231.2_5'UTR	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	215						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GAACAAAACTGAAAGCATTGA	0.358000													9	47					0	0	1	0	0
MAPK8IP2	23542	broad.mit.edu	37	22	51043813	51043813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:51043813C>T	ENST00000399908.2	+	4	1701	c.985C>T	c.(985-987)Ctt>Ttt	p.L329F	MAPK8IP2_ENST00000341339.4_Missense_Mutation_p.L215F|MAPK8IP2_ENST00000442429.2_Missense_Mutation_p.L317F|MAPK8IP2_ENST00000399912.1_Missense_Mutation_p.L329F|MAPK8IP2_ENST00000008876.5_Missense_Mutation_p.L300F|MAPK8IP2_ENST00000329492.3_Missense_Mutation_p.L594F	NM_016431.3	NP_057515.1	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting protein 2	595					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTCCTTTGGCCTTTTCTCCTG	0.647000													6	38					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96104083	96104083	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:96104083C>T	ENST00000453304.1	-	14	2764	c.2416G>A	c.(2416-2418)Ggg>Agg	p.G806R		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	806					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AAGATCTGCCCTTCTCCTTCC	0.522000													31	79					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169756	57169756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57169756G>A	ENST00000371244.4	+	7	967	c.901G>A	c.(901-903)Gaa>Aaa	p.E301K		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	301					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						TGAAAAATTTGAATGTACAGA	0.373000													15	232					0	0	1	0	0
NEDD4	4734	broad.mit.edu	37	15	56207630	56207630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:56207630G>A	ENST00000508342.1	-	1	1699	c.1400C>T	c.(1399-1401)tCc>tTc	p.S467F	NEDD4_ENST00000506154.1_Missense_Mutation_p.S467F|NEDD4_ENST00000338963.2_Missense_Mutation_p.S467F|NEDD4_ENST00000435532.3_Intron			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	467					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		GGATAGACAGGAAATATTTGG	0.358000													42	121					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27537457	27537457	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27537457C>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							AGATATGGATCTTCAACAGTT	0.383000													42	146					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33031217	33031217	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:33031217G>A	ENST00000340811.4	-	3	705	c.597C>T	c.(595-597)atC>atT	p.I199I	PKP2_ENST00000070846.6_Silent_p.I199I	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	199					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding	p.I199I(1)		NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGACCCCCACGATCTCGGAAC	0.597000													18	53					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30948420	30948420	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30948420C>T	ENST00000298139.5	+	15	2040	c.1791C>T	c.(1789-1791)ccC>ccT	p.P597P		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	597	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TTATCTCTCCCCTTATTTCTC	0.358000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				25	134					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53233753	53233753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53233753C>T	ENST00000359499.4	-	7	744	c.733G>A	c.(733-735)Gcc>Acc	p.A245T	KRT78_ENST00000304620.4_Missense_Mutation_p.A355T			Q8N1N4	K2C78_HUMAN	keratin 78	355	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						GTGATGGCGGCCTGCAGGCTG	0.582000													14	27					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29226487	29226487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29226487C>T	ENST00000379558.4	+	6	1120	c.769C>T	c.(769-771)Ctt>Ttt	p.L257F	FAM179A_ENST00000403861.2_Missense_Mutation_p.L257F	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	257							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GCCTGGCTCCCTTCCCAGCCC	0.622000													5	13					0	0	1	0	0
C5orf20	140947	broad.mit.edu	37	5	134782660	134782660	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134782660C>T	ENST00000503143.2	-	1	378	c.139G>A	c.(139-141)Gag>Aag	p.E47K	TIFAB_ENST00000537858.1_3'UTR	NM_130848.2	NP_570900.1	Q8TF63	DCNP1_HUMAN	chromosome 5 open reading frame 20	47						nucleus				endometrium(1)|lung(1)|prostate(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCAAAGTTCTCTGGTGGAGCT	0.612000													4	19					0	0	1	0	0
ZNF174	7727	broad.mit.edu	37	16	3454615	3454615	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3454615C>T	ENST00000268655.4	+	2	1177	c.592C>T	c.(592-594)Ctc>Ttc	p.L198F	ZNF174_ENST00000571936.1_Missense_Mutation_p.L198F|ZNF174_ENST00000344823.5_Missense_Mutation_p.L198F|ZNF174_ENST00000575752.1_Missense_Mutation_p.L198F|LA16c-306E5.2_ENST00000575785.1_RNA|ZNF174_ENST00000572544.1_Missense_Mutation_p.L198F	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	198					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						ATCCCCACTCCTCCAAGAACC	0.532000													23	95					0	0	1	0	0
WSB1	26118	broad.mit.edu	37	17	25630396	25630396	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:25630396C>T	ENST00000262394.2	+	3	529	c.213C>T	c.(211-213)ctC>ctT	p.L71L	WSB1_ENST00000427287.2_Silent_p.L40L|WSB1_ENST00000348811.2_Intron|WSB1_ENST00000583193.1_Intron|WSB1_ENST00000579733.1_Intron|WSB1_ENST00000578312.1_3'UTR|WSB1_ENST00000581185.1_Silent_p.L71L	NM_015626.8	NP_056441.6	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box containing 1	71					intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		ACTCCAGTCTCTTGCATGGCA	0.368000													44	65					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86896591	86896591	+	Silent	SNP	C	C	T	rs147947036	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86896591C>T	ENST00000370565.4	+	4	684	c.522C>T	c.(520-522)ttC>ttT	p.F174F		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	174					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		GGGGTGTGTTCGATGAGTATA	0.373000													50	105					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100700	168100700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:168100700G>A	ENST00000409195.1	+	9	2887	c.2798G>A	c.(2797-2799)cGa>cAa	p.R933Q	XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.R933Q|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.R711Q	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	758					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAGTACACACGAACAGTGAAA	0.333000													25	51					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99438711	99438711	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99438711C>T	ENST00000397899.2	-	7	2356	c.2025G>A	c.(2023-2025)ccG>ccA	p.P675P		NM_207362.2	NP_997245.2			KIAA1211-like									p.P675P(1)									TGTCCTCACTCGGGGCCGGCT	0.711000													8	12					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72992610	72992610	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72992610C>T	ENST00000268489.5	-	2	2107	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	479	Poly-Glu.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				tcctcctcctcttcttcctcc	0.592000													10	50					0	0	1	0	0
GPR183	1880	broad.mit.edu	37	13	99948140	99948140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:99948140C>T	ENST00000376414.4	-	2	343	c.260G>A	c.(259-261)cGa>cAa	p.R87Q	UBAC2_ENST00000403766.3_Intron|UBAC2_ENST00000376440.2_Intron	NM_004951.4	NP_004942.1	P32249	GP183_HUMAN	G protein-coupled receptor 183	87					humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	23						GTAGGCTATTCGTGTAGGCAA	0.408000													40	81					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153864657	153864657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:153864657C>T	ENST00000511601.1	+	2	636	c.448C>T	c.(448-450)Cct>Tct	p.P150S	FHDC1_ENST00000260008.3_Missense_Mutation_p.P150S			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	150	FH2.				actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GTCTTCCCTTCCTAGGAGAGG	0.478000													28	81					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793286	17793286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17793286C>T	ENST00000379472.3	+	2	675	c.645C>T	c.(643-645)ttC>ttT	p.F215F	KCNC1_ENST00000265969.6_Silent_p.F215F	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	215						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						ACGAGCGCTTCAACCCCATCG	0.567000													38	84					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34079764	34079764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34079764C>T	ENST00000254466.6	-	1	133	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K	GAS2L2_ENST00000587565.1_Missense_Mutation_p.E36K	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	36	CH.				cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCCAGGTCTTCCTTCATGGCC	0.632000													31	45					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688681	55688681	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55688681G>A	ENST00000358433.2	-	1	335	c.336C>T	c.(334-336)ctC>ctT	p.L112L		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGGCAGCCAGGAGGTAAAACT	0.393000													31	57					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456634	5456634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5456634G>A	ENST00000222033.4	+	1	1209	c.1132G>A	c.(1132-1134)Ggc>Agc	p.G378S		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	378						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CTCCCTACCGGGCCACCGGCC	0.682000													29	96					0	0	1	0	0
PLBD1	79887	broad.mit.edu	37	12	14664469	14664469	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14664469C>T	ENST00000240617.5	-	7	1673	c.1021G>A	c.(1021-1023)Gac>Aac	p.D341N		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	341					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						GAAAAGATGTCTGCCCACCTC	0.428000													62	148					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176992706	176992706	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176992706C>T	ENST00000367654.2	-	7	1285	c.1270_splice	c.e7-1	p.G424_splice	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Splice_Site_p.G424_splice|ASTN1_ENST00000367657.3_Splice_Site_p.G424_splice|ASTN1_ENST00000361833.2_Splice_Site_p.G424_splice			O14525	ASTN1_HUMAN	astrotactin 1	424					cell migration|neuron cell-cell adhesion	integral to membrane		p.G424G(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TGAAGCGGCTCCCTGCAGGGT	0.552000													5	26					0	0	1	0	0
ZNF625	90589	broad.mit.edu	37	19	12256753	12256753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12256753C>T	ENST00000355738.1	-	4	629	c.280G>A	c.(280-282)Ggg>Agg	p.G94R	ZNF625_ENST00000439556.2_Missense_Mutation_p.G160R|ZNF625_ENST00000542938.1_Missense_Mutation_p.G94R|ZNF625_ENST00000455799.1_3'UTR|ZNF625-ZNF20_ENST00000430024.1_Intron			Q96I27	ZN625_HUMAN	zinc finger protein 625	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(4)|skin(2)	14						TAAGGTTTCCCCCCAGTGTGA	0.428000													18	148					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39228121	39228121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39228121C>T	ENST00000340369.3	-	2	3044	c.2816G>A	c.(2815-2817)aGt>aAt	p.S939N	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.S939N	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	939							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTGCAGGCCACTCAGGTCTCC	0.632000													19	61					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37974775	37974775	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37974775G>A	ENST00000377707.3	-	3	1463	c.898C>T	c.(898-900)Cct>Tct	p.P300S	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	300	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GGTTCGTAAGGGGTGTCATAT	0.537000													28	54					0	0	1	0	0
TBX5	6910	broad.mit.edu	37	12	114841688	114841688	+	Missense_Mutation	SNP	C	C	T	rs145365553		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:114841688C>T	ENST00000310346.4	-	2	682	c.16G>A	c.(16-18)Gag>Aag	p.E6K	TBX5_ENST00000552726.1_5'UTR|TBX5_ENST00000349716.5_Intron|TBX5_ENST00000405440.2_Missense_Mutation_p.E6K|TBX5_ENST00000526441.1_Missense_Mutation_p.E6K	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	6					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.E6*(2)|p.E6K(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CCAAAGCCCTCGTCTGCGTCG	0.677000													9	37					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53668977	53668977	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53668977G>A	ENST00000600412.1	-	2	686	c.571C>T	c.(571-573)Cat>Tat	p.H191Y	ZNF665_ENST00000396424.3_Missense_Mutation_p.H256Y			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TCTCCAGTATGAATTCTCTGA	0.398000													53	127					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39895244	39895244	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:39895244G>A	ENST00000373186.4	-	1	211	c.74C>T	c.(73-75)tCc>tTc	p.S25F	MOCS1_ENST00000373195.3_Intron|MOCS1_ENST00000340692.5_Intron|MOCS1_ENST00000425303.2_Missense_Mutation_p.S25F|MOCS1_ENST00000432280.2_Intron|MOCS1_ENST00000373188.2_Intron|MOCS1_ENST00000308559.7_Intron|MOCS1_ENST00000373175.4_Intron	NM_005943.5	NP_005934.2	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	24	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACCGGGCTGGGAAGAGGCACA	0.632000													9	13					0	0	1	0	0
TAF1C	9013	broad.mit.edu	37	16	84213612	84213612	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84213612G>A	ENST00000567759.1	-	13	1821	c.1639C>T	c.(1639-1641)Cct>Tct	p.P547S	TAF1C_ENST00000378541.4_Missense_Mutation_p.P547S|TAF1C_ENST00000566732.1_Missense_Mutation_p.P521S|TAF1C_ENST00000570117.1_Missense_Mutation_p.P215S|TAF1C_ENST00000541676.1_Missense_Mutation_p.P454S|TAF1C_ENST00000341690.6_Missense_Mutation_p.P453S	NM_005679.3	NP_005670.3	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	547					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						TCCAGCAGAGGAAATGCAGGG	0.652000													16	25					0	0	1	0	0
MAPK13	5603	broad.mit.edu	37	6	36099123	36099123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36099123C>T	ENST00000211287.4	+	2	457	c.195C>T	c.(193-195)ttC>ttT	p.F65F	MAPK13_ENST00000373761.6_Silent_p.F65F|MAPK13_ENST00000490334.1_3'UTR|MAPK13_ENST00000373766.5_Silent_p.F65F|MAPK13_ENST00000373759.1_5'UTR	NM_002754.4	NP_002745.1	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	65	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|prostate(2)|skin(1)	12						CCGAGATCTTCGCCAAGCGCG	0.662000													13	80					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2096748	2096748	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:2096748C>T	ENST00000382203.1	+	20	3184	c.2975C>T	c.(2974-2976)tCt>tTt	p.S992F	SMARCA2_ENST00000382194.1_Missense_Mutation_p.S992F|SMARCA2_ENST00000349721.2_Missense_Mutation_p.S992F|SMARCA2_ENST00000357248.2_Missense_Mutation_p.S992F			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	992					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ACAGATGGTTCTGAGAAAGAT	0.448000													13	99					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44415468	44415468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44415468C>T	ENST00000372343.3	+	2	1126	c.464C>T	c.(463-465)tCa>tTa	p.S155L		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	155					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCTGAGGACTCACCAGTGGAT	0.617000													6	24					0	0	1	0	0
TSPYL1	7259	broad.mit.edu	37	6	116599704	116599704	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116599704C>T	ENST00000368608.3	-	1	1362	c.1290G>A	c.(1288-1290)agG>agA	p.R430R	DSE_ENST00000540275.1_Intron	NM_003309.3	NP_003300.1	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	430					nucleosome assembly	nucleolus				breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(3)|urinary_tract(1)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		ACCCAAAGGGCCTGGGGATCT	0.552000													15	49					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502631	20502631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20502631C>T	ENST00000315693.2	-	1	288	c.287G>A	c.(286-288)gGa>gAa	p.G96E		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GGAATAACATCCCCACCATGA	0.463000													30	60					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187509917	187509917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187509917G>A	ENST00000441802.2	-	27	13805	c.13596C>T	c.(13594-13596)gtC>gtT	p.V4532V		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4532					actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GCATGCTCTCGACAGCGGGCG	0.557000										HNSCC(5;0.00058)			13	51					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152499804	152499804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152499804C>T	ENST00000427231.2	-	58	8222	c.8020G>A	c.(8020-8022)Gag>Aag	p.E2674K	NEB_ENST00000409198.1_Missense_Mutation_p.E2674K|NEB_ENST00000397345.3_Missense_Mutation_p.E2674K|NEB_ENST00000604864.1_Missense_Mutation_p.E2674K|NEB_ENST00000172853.10_Missense_Mutation_p.E2674K|NEB_ENST00000603639.1_Missense_Mutation_p.E2674K	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	2674					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTCATCCTCGAGAGAACCA	0.408000													24	77					0	0	1	0	0
ENKUR	219670	broad.mit.edu	37	10	25273813	25273813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25273813C>T	ENST00000331161.4	-	5	835	c.616G>A	c.(616-618)Gag>Aag	p.E206K	ENKUR_ENST00000376363.1_Missense_Mutation_p.E206K	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	206						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						TTATGCACCTCTTCCCAGTTC	0.393000													19	48					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098663	144098663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:144098663G>A	ENST00000467773.1	-	4	319	c.320C>T	c.(319-321)gCt>gTt	p.A107V	NOBOX_ENST00000223140.5_Missense_Mutation_p.A22V|NOBOX_ENST00000483238.1_Missense_Mutation_p.A107V	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	107					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					GGGTCCTGCAGCCAGGGGCTT	0.607000													7	59					0	0	1	0	0
NCS1	23413	broad.mit.edu	37	9	132985378	132985378	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:132985378C>T	ENST00000372398.3	+	6	500	c.414C>T	c.(412-414)ctC>ctT	p.L138L	NCS1_ENST00000458469.1_Silent_p.L120L	NM_014286.3	NP_055101.2	P62166	NCS1_HUMAN	neuronal calcium sensor 1	138					negative regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of neuron projection development	cell junction|Golgi cisterna membrane|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|protein binding			large_intestine(1)|lung(4)|stomach(1)	6						CCGTGGAGCTCCCAGAGGAGG	0.657000													11	41					0	0	1	0	0
PRSS50	29122	broad.mit.edu	37	3	46754528	46754528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46754528C>T	ENST00000460241.1	-	10	2454	c.784G>A	c.(784-786)Gag>Aag	p.E262K	PRSS50_ENST00000315170.7_Missense_Mutation_p.E262K			Q9UI38	TSP50_HUMAN	protease, serine, 50	262	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						ACTTCCTTCTCCTGAATGGTC	0.532000													81	189					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45430210	45430210	+	Missense_Mutation	SNP	G	G	A	rs138913762		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45430210G>A	ENST00000321429.4	+	11	1518	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	DUOX1_ENST00000389037.3_Missense_Mutation_p.E371K	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	371	Peroxidase-like; mediates peroxidase activity.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTGGAGCCGTGAGGTCCGAGC	0.537000													14	62					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17010355	17010355	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17010355G>A	ENST00000443236.1	-	37	4951	c.4920C>T	c.(4918-4920)ctC>ctT	p.L1640L		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1593						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GCTTGTCAAGGAGCAGCTGCA	0.577000													15	42					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99798917	99798917	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:99798917G>A	ENST00000259470.5	-	5	758	c.509C>T	c.(508-510)tCg>tTg	p.S170L	CTSV_ENST00000538255.1_Missense_Mutation_p.S170L	NM_001333.3	NP_001324.2			cathepsin V																		TTGAGGACGCGAACAGTCCAC	0.527000													24	77					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90077323	90077323	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90077323C>T	ENST00000405460.2	+	65	13255	c.13159C>T	c.(13159-13161)Cgc>Tgc	p.R4387C	GPR98_ENST00000425867.2_Missense_Mutation_p.R48C	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4387					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTCCATTGTTCGCATCATAAT	0.363000													10	23					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204951123	204951123	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204951123C>T	ENST00000367172.4	+	21	2773	c.2445C>T	c.(2443-2445)tcC>tcT	p.S815S	NFASC_ENST00000404076.1_Silent_p.S794S|NFASC_ENST00000513543.1_Silent_p.S811S|NFASC_ENST00000367171.4_Silent_p.S800S|NFASC_ENST00000339876.6_Silent_p.S815S|NFASC_ENST00000539706.1_Silent_p.S811S|NFASC_ENST00000404907.1_Silent_p.S811S|NFASC_ENST00000360049.4_Silent_p.S811S|NFASC_ENST00000367170.4_Silent_p.S815S|NFASC_ENST00000401399.1_Silent_p.S815S|NFASC_ENST00000367169.4_Silent_p.S815S|NFASC_ENST00000338586.6_Silent_p.S815S|NFASC_ENST00000338515.6_Silent_p.S815S			O94856	NFASC_HUMAN	neurofascin	815	Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGCCAGAGTCCGTCATCGGTT	0.622000													5	9					0	0	1	0	0
RNF6	6049	broad.mit.edu	37	13	26789042	26789042	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:26789042G>A	ENST00000381588.4	-	5	1729	c.977C>T	c.(976-978)tCc>tTc	p.S326F	RNF6_ENST00000399762.2_Intron|RNF6_ENST00000346166.3_Missense_Mutation_p.S326F|RNF6_ENST00000468480.1_Intron|RNF6_ENST00000381570.3_Missense_Mutation_p.S326F	NM_005977.3	NP_005968.1	Q9Y252	RNF6_HUMAN	ring finger protein (C3H2C3 type) 6	326	Arg-rich.				negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(3)|ovary(2)|prostate(2)|skin(2)	23	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		TTCCCTTTGGGAATTATGATA	0.413000													53	114					0	0	1	0	0
FAIM3	9214	broad.mit.edu	37	1	207095173	207095173	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207095173G>A	ENST00000367091.3	-	1	170	c.27C>T	c.(25-27)taC>taT	p.Y9Y	FAIM3_ENST00000442471.2_Silent_p.Y9Y|FAIM3_ENST00000420007.2_Silent_p.Y9Y|FAIM3_ENST00000528654.1_5'UTR	NM_005449.4	NP_005440.1	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3	9					anti-apoptosis|cellular defense response	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(84;0.201)					CTGGCAGGAAGTAAAGTGGCC	0.507000													26	52					0	0	1	0	0
OR6B1	135946	broad.mit.edu	37	7	143701978	143701978	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143701978G>A	ENST00000408922.2	+	1	957	c.889G>A	c.(889-891)Gaa>Aaa	p.E297K		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K296fs*1(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					AGAGGTCAAGGAAGCTCTGAA	0.433000													6	59					0	0	1	0	0
TMEM211	255349	broad.mit.edu	37	22	25331309	25331309	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25331309C>T	ENST00000407886.1	-	4	633	c.381G>A	c.(379-381)atG>atA	p.M127I	TMEM211_ENST00000382744.1_Missense_Mutation_p.M127I|TMEM211_ENST00000423535.1_Missense_Mutation_p.M198I			Q6ICI0	TM211_HUMAN	transmembrane protein 211	198						integral to membrane				endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						TTTATTTGTTCATTTCTGGCA	0.483000													40	101					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123600430	123600430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123600430G>A	ENST00000336139.4	-	4	868	c.506C>T	c.(505-507)tCg>tTg	p.S169L	ZNF202_ENST00000530393.1_Missense_Mutation_p.S169L|ZNF202_ENST00000529691.1_Missense_Mutation_p.S169L			O95125	ZN202_HUMAN	zinc finger protein 202	169					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CTCGGGGGTCGAGCTTTGCAC	0.597000													7	36					0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317530	154317530	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154317530C>T	ENST00000368489.3	+	22	2469	c.2469C>T	c.(2467-2469)acC>acT	p.T823T		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	809					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCCGGGTGACCCCCTTGCAGA	0.552000											OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	123					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71472148	71472148	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71472148C>T	ENST00000322937.6	+	13	1148	c.1045C>T	c.(1045-1047)Ccc>Tcc	p.P349S	AMBN_ENST00000449493.2_Missense_Mutation_p.P334S	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	349					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			AGAACCTGCTCCCCACGCAGG	0.592000													7	40					0	0	1	0	0
DPF2	5977	broad.mit.edu	37	11	65113244	65113244	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65113244C>T	ENST00000528416.1	+	7	878	c.745C>T	c.(745-747)Cct>Tct	p.P249S	DPF2_ENST00000252268.4_Missense_Mutation_p.P263S|DPF2_ENST00000415073.2_Intron|DPF2_ENST00000532264.1_3'UTR	NM_006268.4	NP_006259.1	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	249					apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)	23						ACCACCCACTCCTGTTTCCCA	0.532000													18	43					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166892569	166892569	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166892569C>T	ENST00000423058.2	-	16	3435	c.3418G>A	c.(3418-3420)Gaa>Aaa	p.E1140K	AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.E1129K|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.E1140K|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.E1112K	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1140						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTTTGCTTTCTTCCAGATCC	0.358000													33	116					0	0	1	0	0
POLR3D	661	broad.mit.edu	37	8	22107731	22107731	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22107731C>T	ENST00000397802.4	+	7	1280	c.1065C>T	c.(1063-1065)tcC>tcT	p.S355S	POLR3D_ENST00000306433.4_Silent_p.S355S			P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	355					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	13				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CTGCCTGCTCCTTCCTGCAGG	0.562000													17	41					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039962	31039962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:31039962C>T	ENST00000355537.3	+	4	3583	c.3436C>T	c.(3436-3438)Ccc>Tcc	p.P1146S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AGAGGATGTCCCCATCCTGAT	0.552000													20	71					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134144055	134144055	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134144055G>A	ENST00000220616.4	+	46	7902		c.e46-1		TG_ENST00000377869.1_Splice_Site|TG_ENST00000519543.1_Splice_Site|TG_ENST00000542445.1_Splice_Site	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin						hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGTTTTCTCAGCCTGGAGCTG	0.463000													11	61					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25819833	25819833	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:25819833G>A	ENST00000399878.3	-	9	1613	c.1491C>T	c.(1489-1491)ttC>ttT	p.F497F	SEL1L3_ENST00000264868.5_Silent_p.F462F|SEL1L3_ENST00000502949.1_Silent_p.F344F	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	497						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						TCTCCCAGGGGAAGGCTCTGC	0.552000													4	9					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49378993	49378993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49378993C>T	ENST00000200453.5	+	3	2057	c.1788C>T	c.(1786-1788)atC>atT	p.I596I		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	596					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		CACGCCGCATCACCCAGGCCC	0.726000													79	187					0	0	1	0	0
GALNTL5	168391	broad.mit.edu	37	7	151705022	151705022	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151705022C>T	ENST00000392800.2	+	7	1273	c.1019C>T	c.(1018-1020)tCa>tTa	p.S340L	GALNTL5_ENST00000431418.2_Missense_Mutation_p.S340L|GALNTL5_ENST00000483959.1_3'UTR	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	340	Catalytic subdomain B.					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		TTGGAACTTTCACTAAGGGTA	0.328000													33	94					0	0	1	0	0
GALNT16	57452	broad.mit.edu	37	14	69818888	69818888	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:69818888G>A	ENST00000337827.4	+	15	2006		c.e15+1		GALNT16_ENST00000448469.3_3'UTR	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		ACACATGACGGTAGCCCTGGG	0.612000													6	18					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29044154	29044154	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29044154C>T	ENST00000257189.4	+	9	1163	c.1080C>T	c.(1078-1080)atC>atT	p.I360I		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	360	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AATCAGTTATCTCTCGATACC	0.368000													24	60					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2795344	2795344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2795344C>T	ENST00000399655.1	+	45	5958	c.5693C>T	c.(5692-5694)tCc>tTc	p.S1898F	CACNA1C_ENST00000399637.1_Missense_Mutation_p.S1917F|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000335762.5_Missense_Mutation_p.S1923F|CACNA1C_ENST00000399603.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000399649.1_Missense_Mutation_p.S1904F|CACNA1C_ENST00000399595.1_Missense_Mutation_p.S1906F|CACNA1C_ENST00000399606.1_Missense_Mutation_p.S1918F|CACNA1C_ENST00000399601.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000399617.1_Missense_Mutation_p.S1933F|CACNA1C_ENST00000344100.3_Missense_Mutation_p.S1939F|CACNA1C_ENST00000399621.1_Missense_Mutation_p.S1917F|CACNA1C_ENST00000399629.1_Missense_Mutation_p.S1915F|CACNA1C_ENST00000327702.7_Missense_Mutation_p.S1933F|CACNA1C_ENST00000406454.3_Missense_Mutation_p.S1969F|CACNA1C_ENST00000402845.3_Missense_Mutation_p.S1917F|CACNA1C_ENST00000399597.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000347598.4_Missense_Mutation_p.S1946F|CACNA1C_ENST00000399641.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000399638.1_Missense_Mutation_p.S1926F|CACNA1C_ENST00000399644.1_Missense_Mutation_p.S1898F|CACNA1C_ENST00000399591.1_Missense_Mutation_p.S1906F|CACNA1C_ENST00000399634.1_Missense_Mutation_p.S1969F	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1981					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CGAAGGGCCTCCTTCCACCTG	0.582000													36	87					0	0	1	0	0
GALNTL5	168391	broad.mit.edu	37	7	151711762	151711762	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151711762C>T	ENST00000392800.2	+	8	1314	c.1060C>T	c.(1060-1062)Ccc>Tcc	p.P354S	GALNTL5_ENST00000431418.2_Missense_Mutation_p.P354S	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	354	Catalytic subdomain B.					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		CTTTATAATCCCCTGCTCTCG	0.398000													34	96					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23885428	23885428	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23885428C>T	ENST00000355349.3	-	34	4900	c.4738G>A	c.(4738-4740)Gac>Aac	p.D1580N		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1580					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ATCTCCTCGTCCTTCTCTGCC	0.642000													70	183					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61987410	61987410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:61987410G>A	ENST00000409186.1	-	5	2927	c.822C>T	c.(820-822)gtC>gtT	p.V274V	PCDH20_ENST00000409204.4_Silent_p.V274V			Q8N6Y1	PCD20_HUMAN	protocadherin 20	247	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AAGCACCCATGACAATTAGGT	0.527000													27	40					0	0	1	0	0
ZNF556	80032	broad.mit.edu	37	19	2876142	2876142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2876142C>T	ENST00000586426.1	+	3	269	c.182C>T	c.(181-183)tCt>tTt	p.S61F	ZNF556_ENST00000307635.2_Missense_Mutation_p.S61F			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGATACTTCTGGAGAAAAA	0.368000													53	191					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10419850	10419850	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10419850G>A	ENST00000226207.5	-	3	204	c.110C>T	c.(109-111)tCa>tTa	p.S37L	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	37	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CACAAAGACTGATGTCTTGGC	0.522000													20	175					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28547306	28547306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:28547306C>T	ENST00000357727.2	+	4	632	c.242C>T	c.(241-243)tCc>tTc	p.S81F	CREB5_ENST00000396300.2_Missense_Mutation_p.S74F|CREB5_ENST00000409603.1_Missense_Mutation_p.S48F|CREB5_ENST00000396299.2_Missense_Mutation_p.S48F	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	81					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						CTGGACTGCTCCCTGGAGCAC	0.552000													58	151					0	0	1	0	0
PHEX	5251	broad.mit.edu	37	X	22112104	22112104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:22112104C>T	ENST00000379374.4	+	7	1301	c.736C>T	c.(736-738)Cgg>Tgg	p.R246W	PHEX_ENST00000475778.1_3'UTR|PHEX_ENST00000537599.1_Missense_Mutation_p.R246W|PHEX_ENST00000535894.1_Missense_Mutation_p.R149W	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	246					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						CTTACAGTATCGGGATGCCCT	0.398000													69	36					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276978	71276978	+	Silent	SNP	C	C	T	rs77786965		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71276978C>T	ENST00000398531.1	+	1	370	c.345C>T	c.(343-345)ggC>ggT	p.G115G	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	115	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GGGGCTGTGGCTCCTGTGGGG	0.667000													58	143					0	0	1	0	0
GMEB2	26205	broad.mit.edu	37	20	62221711	62221711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62221711G>A	ENST00000266068.1	-	9	1802	c.1324C>T	c.(1324-1326)Ccc>Tcc	p.P442S	GMEB2_ENST00000370069.1_Missense_Mutation_p.P391S|GMEB2_ENST00000370077.1_Missense_Mutation_p.P442S			Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding protein 2	442					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	18	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			ACTGTGCTGGGGTAGGTGGAG	0.697000													9	25					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832614	61832614	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61832614C>T	ENST00000280772.1	-	37	8216	c.8025G>A	c.(8023-8025)aaG>aaA	p.K2675K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2675					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGAGAACCATCTTCTCTGGGC	0.557000													25	79					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141536293	141536293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141536293C>T	ENST00000350549.3	-	5	981	c.610G>A	c.(610-612)Gga>Aga	p.G204R	PRSS37_ENST00000438520.1_Missense_Mutation_p.G204R	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	204	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						ACCTCGATTCCCTGGAGCTTG	0.498000													31	68					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4855892	4855892	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4855892C>T	ENST00000399583.3	-	8	2120	c.1933G>A	c.(1933-1935)Ggg>Agg	p.G645R	RADIL_ENST00000538469.1_Missense_Mutation_p.G405R|RADIL_ENST00000536091.1_3'UTR	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	645	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		AGCAGTGTCCCGGAGAAGAAG	0.657000													9	39					0	0	1	0	0
METTL7B	196410	broad.mit.edu	37	12	56075728	56075728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56075728G>A	ENST00000394252.3	+	1	399	c.190G>A	c.(190-192)Ggg>Agg	p.G64R		NM_152637.2	NP_689850.2	Q6UX53	MET7B_HUMAN	methyltransferase like 7B	64							methyltransferase activity			kidney(1)|large_intestine(1)|lung(4)	6						CCAGATAAAGGGGCTTACAGG	0.592000													9	24					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83182714	83182714	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:83182714C>T	ENST00000398309.2	-	19	2556	c.2086G>A	c.(2086-2088)Gac>Aac	p.D696N	DLG2_ENST00000376106.3_Missense_Mutation_p.D160N|DLG2_ENST00000524982.1_Missense_Mutation_p.D692N|DLG2_ENST00000532653.1_Missense_Mutation_p.D678N|DLG2_ENST00000330014.6_Missense_Mutation_p.D617N|DLG2_ENST00000543673.1_Missense_Mutation_p.D801N|DLG2_ENST00000376104.2_Missense_Mutation_p.D801N|DLG2_ENST00000280241.8_Missense_Mutation_p.D735N|DLG2_ENST00000531015.1_Missense_Mutation_p.D663N|DLG2_ENST00000537455.1_Missense_Mutation_p.D446N|DLG2_ENST00000418306.2_Missense_Mutation_p.D575N|DLG2_ENST00000426717.2_Missense_Mutation_p.D160N|DLG2_ENST00000404783.3_Missense_Mutation_p.D174N	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	696	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GATATCAAGTCGTCATTGATC	0.428000													14	40					0	0	1	0	0
ADRA2A	150	broad.mit.edu	37	10	112838991	112838991	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:112838991G>A	ENST00000280155.2	+	1	2202	c.1237G>A	c.(1237-1239)Gcc>Acc	p.A413T		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	398					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	CACGCTCACGGCCGTCGGGTG	0.582000													40	108					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6471258	6471258	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6471258G>A	ENST00000358945.3	-	3	1274	c.834C>T	c.(832-834)ttC>ttT	p.F278F	SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000543768.1_Silent_p.F301F|SCNN1A_ENST00000396966.2_Silent_p.F278F|SCNN1A_ENST00000360168.3_Silent_p.F337F|SCNN1A_ENST00000228916.2_Silent_p.F278F|SCNN1A_ENST00000540037.1_5'UTR			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	278					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	AGGCGAAGATGAAGTTGCCCA	0.622000													5	65					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80729743	80729743	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:80729743C>T	ENST00000458043.2	+	38	4402	c.4395_splice	c.e38-1	p.P1466_splice	OTOGL_ENST00000547103.1_Splice_Site_p.P1454_splice	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTATTAACAGCCTCAGAAATT	0.328000													7	42					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705578	101705578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:101705578C>T	ENST00000305352.6	+	2	1413	c.1038C>T	c.(1036-1038)gcC>gcT	p.A346A		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	346					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						CCATCATCGCCGGCATGGAAT	0.552000													10	184					0	0	1	0	0
ALOX12B	242	broad.mit.edu	37	17	7989509	7989509	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7989509C>T	ENST00000319144.4	-	2	437	c.177G>A	c.(175-177)caG>caA	p.Q59Q		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	59	PLAT.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						CACCCAGGTCCTGAGGGCACT	0.632000										Multiple Myeloma(8;0.094)			5	26					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50592458	50592458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:50592458G>A	ENST00000442544.2	+	7	1799	c.1183G>A	c.(1183-1185)Gaa>Aaa	p.E395K	DCC_ENST00000580146.1_3'UTR|DCC_ENST00000412726.1_Missense_Mutation_p.E243K|DCC_ENST00000581580.1_Missense_Mutation_p.E50K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	395	Ig-like C2-type 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GAAGTCAGATGAAGGCTTTTA	0.443000													12	190					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90079864	90079864	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90079864G>A	ENST00000405460.2	+	67	13739	c.13643G>A	c.(13642-13644)gGa>gAa	p.G4548E	GPR98_ENST00000425867.2_Missense_Mutation_p.G209E	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4548					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGACTCTTGGGAGAGATTCAG	0.363000													6	10					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168244307	168244307	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168244307G>A	ENST00000519560.1	-	8	1210	c.791C>T	c.(790-792)cCa>cTa	p.P264L	SLIT3_ENST00000332966.8_Missense_Mutation_p.P264L|SLIT3_ENST00000404867.3_Missense_Mutation_p.P264L	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	264	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCCTCACCTGGGCACACGTA	0.572000													19	41					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145103957	145103957	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:145103957G>A	ENST00000453618.1	+	0	452							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										TAACTCTTTCGAAAGTTGAAT	0.393000													6	38					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133846313	133846313	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:133846313G>A	ENST00000367895.5	+	19	2224	c.1760G>A	c.(1759-1761)cGa>cAa	p.R587Q	EYA4_ENST00000355167.3_Intron|EYA4_ENST00000452339.2_Intron|EYA4_ENST00000430974.2_Intron|EYA4_ENST00000355286.6_Missense_Mutation_p.R564Q|EYA4_ENST00000531901.1_Missense_Mutation_p.R593Q|RP3-323P13.2_ENST00000607033.1_RNA|EYA4_ENST00000431403.2_Intron|EYA4_ENST00000525849.1_Intron	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	587					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TGCTTTGAACGAATAATGCAA	0.408000													38	48					0	0	1	0	0
MT1F	4494	broad.mit.edu	37	16	56693046	56693046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:56693046G>A	ENST00000334350.6	+	3	521	c.156G>A	c.(154-156)ggG>ggA	p.G52G	MT1F_ENST00000394501.2_Silent_p.G53G|MT1F_ENST00000568475.1_3'UTR			P04733	MT1F_HUMAN	metallothionein 1F	52	Alpha.					cytoplasm	cadmium ion binding|copper ion binding|zinc ion binding										TTTGCAAAGGGGCGTCAGAGA	0.527000													10	153					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048826	9048826	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9048826G>A	ENST00000397910.4	-	5	33008	c.32805C>T	c.(32803-32805)acC>acT	p.T10935T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10937	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGACCAGAGAGGTCACCACTC	0.498000													45	89					0	0	1	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61908562	61908562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:61908562C>T	ENST00000370275.4	+	5	440	c.348C>T	c.(346-348)gtC>gtT	p.V116V	ARFGAP1_ENST00000370283.4_Silent_p.V116V|ARFGAP1_ENST00000353546.3_Silent_p.V116V|ARFGAP1_ENST00000547204.1_Silent_p.V42V|ARFGAP1_ENST00000519273.2_Intron|ARFGAP1_ENST00000519604.1_Silent_p.V63V			Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	116	Arf-GAP.				COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					GTCAGGTGGTCGCTCTGGCCG	0.667000													10	21					0	0	1	0	0
HDAC7	51564	broad.mit.edu	37	12	48181838	48181838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48181838G>A	ENST00000080059.7	-	20	2344	c.2345C>T	c.(2344-2346)gCt>gTt	p.A782V	HDAC7_ENST00000427332.2_Missense_Mutation_p.A743V|HDAC7_ENST00000380610.4_Missense_Mutation_p.A799V|HDAC7_ENST00000354334.3_Missense_Mutation_p.A745V|HDAC7_ENST00000552960.1_Missense_Mutation_p.A765V	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	743	Histone deacetylase.				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		CTCATCCACAGCCCCACTCCC	0.572000													11	44					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	333251	333251	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:333251G>A	ENST00000343164.4	-	11	1270	c.1218C>T	c.(1216-1218)taC>taT	p.Y406Y	SLC6A13_ENST00000445055.2_Silent_p.Y314Y|SLC6A13_ENST00000539668.1_5'UTR	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	406					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			ACACGTGAGGGTACATGTCCA	0.562000													14	42					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20976098	20976098	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20976098G>A	ENST00000261383.3	-	53	9107	c.9108C>T	c.(9106-9108)ttC>ttT	p.F3036F	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3036					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGAAGTCACTGAAGCCAGGGA	0.522000													17	40					0	0	1	0	0
SERINC3	10955	broad.mit.edu	37	20	43142617	43142617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43142617G>A	ENST00000342374.4	-	2	261	c.104C>T	c.(103-105)tCc>tTc	p.S35F	SERINC3_ENST00000255175.1_Missense_Mutation_p.S35F|SERINC3_ENST00000541235.1_5'UTR|SERINC3_ENST00000468234.1_5'UTR	NM_006811.2	NP_006802.1	Q13530	SERC3_HUMAN	serine incorporator 3	35						integral to membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(2)|lung(8)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			AGTCACCGTGGAATTCTTACT	0.478000													34	91					0	0	1	0	0
KIAA1211L	343990	broad.mit.edu	37	2	99448865	99448865	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:99448865C>T	ENST00000397899.2	-	5	817	c.486G>A	c.(484-486)agG>agA	p.R162R	KIAA1211L_ENST00000462314.1_5'UTR	NM_207362.2	NP_997245.2			KIAA1211-like																		CTGGGGGGCTCCTGGGCAGCC	0.617000													32	68					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143049044	143049044	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143049044G>A	ENST00000343257.2	+	23	3040	c.2953G>A	c.(2953-2955)Gaa>Aaa	p.E985K		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	985					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GGATGAGGATGAACTGATCCT	0.617000													27	92					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6833918	6833918	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6833918G>A	ENST00000304076.2	+	19	1825		c.e19-1		VAV1_ENST00000539284.1_Splice_Site|VAV1_ENST00000602142.1_Splice_Site|VAV1_ENST00000599806.1_Splice_Site|VAV1_ENST00000596764.1_Splice_Site	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						TCTCCTTCCAGGACAAACTAC	0.537000													31	76					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5868478	5868478	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:5868478G>A	ENST00000324989.7	-	2	475	c.387C>T	c.(385-387)gaC>gaT	p.D129D	CRMP1_ENST00000397890.2_Silent_p.D15D|CRMP1_ENST00000512574.1_Silent_p.D13D|CRMP1_ENST00000511535.1_5'UTR	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	15					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		TGAGGAGTCGGTCACTCTGCA	0.378000													14	51					0	0	1	0	0
CLEC4D	338339	broad.mit.edu	37	12	8673861	8673861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8673861G>A	ENST00000299665.2	+	6	835	c.642G>A	c.(640-642)ttG>ttA	p.L214L		NM_080387.4	NP_525126.2	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	214					innate immune response	integral to membrane	sugar binding			large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Lung SC(5;0.184)					GAACAACATTGAACTAGAAAC	0.363000													28	50					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29848108	29848108	+	Missense_Mutation	SNP	G	G	A	rs139726967		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29848108G>A	ENST00000399218.4	-	6	2409	c.2354C>T	c.(2353-2355)cCg>cTg	p.P785L	GAREM_ENST00000269209.6_Missense_Mutation_p.P786L	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1									p.P785L(1)									GAGATGGAGCGGAGATGAGAA	0.547000													20	34					0	0	1	0	0
TANGO6	79613	broad.mit.edu	37	16	68893950	68893950	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68893950C>T	ENST00000261778.1	+	2	270	c.258C>T	c.(256-258)aaC>aaT	p.N86N		NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		GGCCACAAAACTCTGTGGATG	0.433000													24	75					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785187	134785187	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134785187C>T	ENST00000537858.1	-	2	643	c.443G>A	c.(442-444)tGg>tAg	p.W148*		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	148										breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GATGCCTTCCCATTCGTCAGT	0.582000													32	75					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73489018	73489018	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73489018C>T	ENST00000314256.7	+	16	2315	c.1921C>T	c.(1921-1923)Cct>Tct	p.P641S	KIAA0195_ENST00000579208.1_Missense_Mutation_p.P292S|KIAA0195_ENST00000375248.5_Missense_Mutation_p.P651S	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	641					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGCTTCACTCCTGGGGCCAA	0.607000													47	130					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110826801	110826801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110826801C>T	ENST00000375820.4	-	39	3519	c.3398G>A	c.(3397-3399)gGa>gAa	p.G1133E		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1133	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			ACCTGCTTCTCCTTTGACACC	0.547000													16	41					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784638	82784638	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82784638G>A	ENST00000423517.2	-	2	1656	c.1319C>T	c.(1318-1320)cCa>cTa	p.P440L	PCLO_ENST00000333891.8_Missense_Mutation_p.P440L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	391	10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.|Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTGCTGAACTGGAGTCTTTGT	0.577000													22	114					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701687	56701687	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56701687G>A	ENST00000586855.2	-	5	1310	c.997C>T	c.(997-999)Cat>Tat	p.H333Y	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.H333Y			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	333					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CCTGGGGAATGAACTGGATTG	0.547000													37	104					0	0	1	0	0
MYOZ3	91977	broad.mit.edu	37	5	150051192	150051192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150051192G>A	ENST00000297130.4	+	4	449	c.250G>A	c.(250-252)Gga>Aga	p.G84R	CTC-345K18.2_ENST00000511626.2_RNA|MYOZ3_ENST00000517768.1_Missense_Mutation_p.G84R	NM_001122853.2|NM_133371.4	NP_001116325.1|NP_588612.2	Q8TDC0	MYOZ3_HUMAN	myozenin 3	84	Binding to FLNC.					sarcomere	protein binding			large_intestine(2)|lung(1)|skin(2)	5		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAAGGTGACTGGAACAGCGGA	0.682000													13	121					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187004313	187004313	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187004313C>T	ENST00000296795.2	+	4	1577	c.1473C>T	c.(1471-1473)gcC>gcT	p.A491A	TLR3_ENST00000504367.1_Silent_p.A214A	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	491					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		GAAGGGTGGCCCTTAAAAATG	0.448000													50	92					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39872801	39872801	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39872801C>T	ENST00000502986.2	+	11	1185	c.943C>T	c.(943-945)Cct>Tct	p.P315S	IDO2_ENST00000389060.4_Missense_Mutation_p.P302S|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	302					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						TTACATGCCTCCTTCCCATAA	0.463000													25	58					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	47990425	47990425	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:47990425C>T	ENST00000371741.4	-	2	1838	c.1672G>A	c.(1672-1674)Gaa>Aaa	p.E558K		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	558					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCAAGTTCTTCCTTTGGTTTG	0.493000													45	154					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6483644	6483644	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6483644G>A	ENST00000358945.3	-	1	746	c.306C>T	c.(304-306)ttC>ttT	p.F102F	SCNN1A_ENST00000538979.1_Intron|SCNN1A_ENST00000543768.1_Silent_p.F125F|SCNN1A_ENST00000396966.2_Silent_p.F102F|SCNN1A_ENST00000360168.3_Silent_p.F161F|SCNN1A_ENST00000228916.2_Silent_p.F102F			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	102					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	AAAGCAGGCCGAATTGCCAGT	0.587000													9	68					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156816391	156816391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156816391G>A	ENST00000368195.3	-	8	2126	c.1730C>T	c.(1729-1731)gCc>gTc	p.A577V	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	577	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TAGCGTGATGGCCCGCACAAA	0.612000													18	38					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110463245	110463245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110463245G>A	ENST00000378402.5	+	41	6321	c.6217G>A	c.(6217-6219)Ggg>Agg	p.G2073R		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2073	IPT/TIG 13.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTGGTTAATGGGAAAGATTT	0.502000										HNSCC(38;0.096)	OREG0018931	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	27					0	0	1	0	0
RSPH1	89765	broad.mit.edu	37	21	43913099	43913099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43913099C>T	ENST00000291536.3	-	2	312	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	RSPH1_ENST00000398352.3_Intron	NM_080860.2	NP_543136.1	Q8WYR4	RSPH1_HUMAN	radial spoke head 1 homolog (Chlamydomonas)	49					meiosis	cytosol|nucleus				large_intestine(7)|lung(2)|ovary(1)|prostate(1)|stomach(1)	12						TTACCGAATTCGTAGCTCCCT	0.502000													58	252					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16376365	16376365	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16376365G>A	ENST00000375679.4	+	10	1033	c.922G>A	c.(922-924)Ggc>Agc	p.G308S	CLCNKB_ENST00000375667.3_Missense_Mutation_p.G139S	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		AATCTTCTTTGGCTTCATCAG	0.602000													73	139					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	51025755	51025755	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:51025755G>A	ENST00000442544.2	+	27	4602	c.3986G>A	c.(3985-3987)aGa>aAa	p.R1329K	RP11-671P2.1_ENST00000582064.1_RNA|DCC_ENST00000581580.1_Missense_Mutation_p.R962K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1329					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCACCAAGCAGAACCATCCCC	0.542000													46	101					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594458	140594458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140594458G>A	ENST00000341948.4	+	1	950	c.763G>A	c.(763-765)Gac>Aac	p.D255N		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		255	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATCTCTGAGGACAGTCCGGT	0.498000													79	223					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16740758	16740758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:16740758C>T	ENST00000381323.3	-	10	1027	c.807G>A	c.(805-807)gtG>gtA	p.V269V	FAM49A_ENST00000406434.1_Silent_p.V269V|FAM49A_ENST00000355549.2_Silent_p.V269V	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	269						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			AGAAAGCTCCCACAGGGTGGA	0.468000													28	111					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107423438	107423438	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107423438C>T	ENST00000340010.5	-	10	1404	c.1220G>A	c.(1219-1221)gGa>gAa	p.G407E	SLC26A3_ENST00000422236.2_Missense_Mutation_p.G372E	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	407					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TGTTTTGCCTCCTGTGCTCTC	0.468000													40	83					0	0	1	0	0
CSF2	1437	broad.mit.edu	37	5	131411475	131411475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131411475G>A	ENST00000296871.2	+	4	399	c.365G>A	c.(364-366)aGt>aAt	p.S122N		NM_000758.3	NP_000749.2	P04141	CSF2_HUMAN	colony stimulating factor 2 (granulocyte-macrophage)	122					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity			skin(1)	1		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	ACCTTTGAAAGTTTCAAAGAG	0.483000													21	196					0	0	1	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86491725	86491725	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:86491725C>T	ENST00000395184.1	+	2	497	c.31C>T	c.(31-33)Ccc>Tcc	p.P11S	ARHGAP24_ENST00000503995.1_Missense_Mutation_p.P11S|ARHGAP24_ENST00000506421.1_3'UTR	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	11					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CACGGAGAACCCCCAACAAGG	0.468000													13	39					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8152010	8152010	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8152010G>A	ENST00000600128.1	-	54	7119	c.6705C>T	c.(6703-6705)gtC>gtT	p.V2235V	FBN3_ENST00000601739.1_Silent_p.V2235V|FBN3_ENST00000270509.2_Silent_p.V2235V			Q75N90	FBN3_HUMAN	fibrillin 3	2235	EGF-like 36; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CTGGGGGACAGACGCACGCGA	0.627000													15	59					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72169145	72169145	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:72169145C>T	ENST00000555818.1	+	12	3917	c.3569C>T	c.(3568-3570)aCc>aTc	p.T1190I	SIPA1L1_ENST00000381232.3_Missense_Mutation_p.T1190I|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.T665I|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.T1190I|SIPA1L1_ENST00000554874.1_3'UTR	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1190					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AGGCAGAACACCCAGTCAGAT	0.498000													28	49					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107642209	107642209	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107642209G>A	ENST00000393561.1	-	1	263	c.79C>T	c.(79-81)Ccc>Tcc	p.P27S	LAMB1_ENST00000222399.6_Intron|LAMB1_ENST00000393560.1_Intron			P07942	LAMB1_HUMAN	laminin, beta 1	0					axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAGTTGGGGGGACACAAGCA	0.612000													4	23					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056223	9056223	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9056223C>T	ENST00000397910.4	-	3	31426	c.31223G>A	c.(31222-31224)gGa>gAa	p.G10408E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10410	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCACTGTTCCCAGCTCAAC	0.478000													65	182					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173416	126173416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:126173416G>A	ENST00000339582.2	-	9	2828	c.2020C>T	c.(2020-2022)Cac>Tac	p.H674Y	GRM8_ENST00000444921.2_Missense_Mutation_p.H674Y|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Missense_Mutation_p.H674Y			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	674					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AATATTCGGTGGATACGGTTT	0.502000										HNSCC(24;0.065)			23	87					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47278192	47278192	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47278192G>A	ENST00000271153.4	+	4	428	c.392G>A	c.(391-393)gGg>gAg	p.G131E	CYP4B1_ENST00000371919.4_Missense_Mutation_p.G116E|CYP4B1_ENST00000452782.2_5'UTR|CYP4B1_ENST00000371923.4_Missense_Mutation_p.G131E			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	131					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.G131V(1)		NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					GTTCTTGAGGGGCCCAAGTGG	0.587000													11	25					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70924276	70924276	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70924276G>A	ENST00000603540.1	+	2	318	c.60G>A	c.(58-60)ggG>ggA	p.G20G	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_Silent_p.G20G	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	20					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TCTGGCTTGGGGTATTTTTGT	0.537000													47	106					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008550	120008550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:120008550C>T	ENST00000341846.5	-	1	611	c.190G>A	c.(190-192)Gaa>Aaa	p.E64K		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	64					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CTCCTACCTTCCCCTGGCTTC	0.632000													53	156					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579921	140579921	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140579921C>T	ENST00000354757.3	+	1	574	c.574C>T	c.(574-576)Ccc>Tcc	p.P192S	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		192	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGGAAATACCCCGAGTTAGT	0.463000													16	66					0	0	1	0	0
SLC8B1	80024	broad.mit.edu	37	12	113759020	113759020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113759020G>A	ENST00000552014.1	-	4	805	c.290C>T	c.(289-291)cCt>cTt	p.P97L	SLC24A6_ENST00000546737.1_Missense_Mutation_p.P97L|SLC24A6_ENST00000202831.3_Missense_Mutation_p.P97L|SLC24A6_ENST00000553238.1_5'UTR			Q6J4K2	NCKX6_HUMAN		97					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						GACAGCCAGAGGGAGGAGGCT	0.642000													18	114					0	0	1	0	0
KLK12	43849	broad.mit.edu	37	19	51534092	51534092	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51534092C>T	ENST00000529888.1	-	4	358	c.283G>A	c.(283-285)Gag>Aag	p.E95K	KLK12_ENST00000525263.1_Silent_p.T181T|KLK12_ENST00000250352.11_Silent_p.T71T|KLK12_ENST00000319590.4_Silent_p.T181T|CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000250351.4_Silent_p.T181T	NM_145895.1	NP_665902.1	Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	0	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		CCATGTTGCTCGTGATTCTCC	0.617000													59	123					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231216	21231216	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21231216C>T	ENST00000233242.1	-	26	8651	c.8524G>A	c.(8524-8526)Gaa>Aaa	p.E2842K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2842					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACAGCATTTCACTCCCATGC	0.418000													23	216					0	0	1	0	0
USP6NL	9712	broad.mit.edu	37	10	11504574	11504574	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:11504574G>A	ENST00000379237.1	-	15	2747	c.2353C>T	c.(2353-2355)Ccc>Tcc	p.P785S	USP6NL_ENST00000277575.5_Missense_Mutation_p.P802S	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	785						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						TATCTCACGGGACTATCTACA	0.532000													56	165					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101583015	101583015	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:101583015G>A	ENST00000310954.6	-	10	2038	c.1752C>T	c.(1750-1752)ttC>ttT	p.F584F		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	584					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TTACAATAAAGAAAATGCAAA	0.358000													54	86					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14498703	14498703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14498703C>T	ENST00000344204.4	+	53	8310	c.8286C>T	c.(8284-8286)gtC>gtT	p.V2762V	TRIO_ENST00000537187.1_Silent_p.V2586V|TRIO_ENST00000344135.5_Silent_p.V261V	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2762	Ig-like C2-type.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GCATCGCTGTCAATGACATGG	0.587000													42	87					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703603	4703603	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4703603G>A	ENST00000396950.3	-	2	578	c.339C>T	c.(337-339)atC>atT	p.I113I		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGCCAGCAGGATGGTGGATT	0.517000													15	45					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3729195	3729195	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3729195G>T	ENST00000315677.3	-	7	2126	c.1531C>A	c.(1531-1533)Ctg>Atg	p.L511M	DLGAP1_ENST00000478161.1_5'UTR|DLGAP1_ENST00000584874.1_Missense_Mutation_p.L511M|DLGAP1_ENST00000581527.1_Missense_Mutation_p.L511M|DLGAP1_ENST00000581699.1_Missense_Mutation_p.L217M|DLGAP1_ENST00000515196.2_Missense_Mutation_p.L511M|DLGAP1_ENST00000539435.1_Missense_Mutation_p.L209M|DLGAP1_ENST00000400145.2_Missense_Mutation_p.L209M|DLGAP1_ENST00000400150.3_Missense_Mutation_p.L217M|DLGAP1_ENST00000400155.1_Missense_Mutation_p.L217M|DLGAP1_ENST00000400147.2_Missense_Mutation_p.L209M|DLGAP1_ENST00000400149.3_Missense_Mutation_p.L219M|DLGAP1_ENST00000534970.1_Missense_Mutation_p.L223M	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	511					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GACGACCTCAGGGACACGCAC	0.687000													6	41					0.0215528	0.0215557	1	1	0
NID1	4811	broad.mit.edu	37	1	236212147	236212147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236212147C>T	ENST00000264187.6	-	2	450	c.368G>A	c.(367-369)cGa>cAa	p.R123Q	NID1_ENST00000366595.3_Missense_Mutation_p.R123Q	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	123	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TAAGTCTTCTCGATAATAAAC	0.567000													22	66					0	0	1	0	0
SMARCC1	6599	broad.mit.edu	37	3	47703861	47703861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47703861G>A	ENST00000254480.5	-	20	2240	c.2121C>T	c.(2119-2121)gaC>gaT	p.D707D	SMARCC1_ENST00000425518.1_5'UTR	NM_003074.3	NP_003065.3	Q92922	SMRC1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	707					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		CCACGCGAGGGTCCACCACAG	0.478000													17	59					0	0	1	0	0
ATP1B4	23439	broad.mit.edu	37	X	119500593	119500593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:119500593C>T	ENST00000218008.3	+	2	334	c.277C>T	c.(277-279)Ctg>Ttg	p.L93L	ATP1B4_ENST00000539306.1_Silent_p.L93L|ATP1B4_ENST00000361319.3_Silent_p.L93L	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	93					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						GAGTGAATACCTGTGGGATCC	0.502000													20	13					0	0	1	0	0
NOX3	50508	broad.mit.edu	37	6	155757560	155757560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155757560C>T	ENST00000159060.2	-	7	892	c.790G>A	c.(790-792)Gaa>Aaa	p.E264K		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	264	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		ACCGAGGGTTCCTTGCCAGAA	0.438000													32	62					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41423891	41423891	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41423891C>T	ENST00000400454.1	-	30	5656	c.5179G>A	c.(5179-5181)Gga>Aga	p.G1727R		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1727					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCACTCGTTCCCGGCCGAGCG	0.478000													32	178					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144994645	144994645	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144994645G>A	ENST00000322810.4	-	32	9924	c.9755C>T	c.(9754-9756)tCc>tTc	p.S3252F	PLEC_ENST00000354589.3_Missense_Mutation_p.S3115F|PLEC_ENST00000357649.2_Missense_Mutation_p.S3119F|PLEC_ENST00000527096.1_Missense_Mutation_p.S3138F|PLEC_ENST00000356346.3_Missense_Mutation_p.S3101F|PLEC_ENST00000354958.2_Missense_Mutation_p.S3093F|PLEC_ENST00000345136.3_Missense_Mutation_p.S3115F|PLEC_ENST00000436759.2_Missense_Mutation_p.S3142F|PLEC_ENST00000398774.2_Missense_Mutation_p.S3083F	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3252	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CTGGAACAGGGAGACGCTCTG	0.657000													5	21					0	0	1	0	0
PARP9	83666	broad.mit.edu	37	3	122247235	122247235	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122247235G>A	ENST00000360356.2	-	11	2768	c.2541C>T	c.(2539-2541)ttC>ttT	p.F847F	PARP9_ENST00000471785.1_Silent_p.F812F|PARP9_ENST00000477522.2_Silent_p.F812F|PARP9_ENST00000492382.1_Silent_p.F392F	NM_001146102.1|NM_031458.2	NP_001139574.1|NP_113646.2	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	847	PARP catalytic.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		TGCCACTTGCGAATCCCCTCC	0.448000													46	106					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100623364	100623364	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:100623364G>A	ENST00000317233.4	-	6	838	c.603C>T	c.(601-603)gcC>gcT	p.A201A	AFF3_ENST00000409236.1_Silent_p.A201A|AFF3_ENST00000409579.1_Silent_p.A226A|AFF3_ENST00000356421.2_Silent_p.A226A	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	201					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGGCCGCCATGGCAGGTGGCC	0.587000													37	85					0	0	1	0	0
PKM	5315	broad.mit.edu	37	15	72509755	72509755	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72509755G>A	ENST00000319622.6	-	3	697	c.241C>T	c.(241-243)Cat>Tat	p.H81Y	PKM_ENST00000565154.1_Missense_Mutation_p.H81Y|PKM_ENST00000449901.2_Intron|PKM_ENST00000389093.3_Missense_Mutation_p.H81Y|PKM_ENST00000565184.1_Missense_Mutation_p.H81Y|PKM_ENST00000568459.1_Missense_Mutation_p.H81Y|PKM_ENST00000568883.1_Intron|PKM_ENST00000335181.5_Missense_Mutation_p.H81Y	NM_001206796.1|NM_182470.2|NM_182471.2	NP_001193725.1|NP_872270.1|NP_872271.1			pyruvate kinase, muscle											endometrium(1)|lung(7)	8						CTCACCTCATGAGTTCCATGA	0.507000													34	76					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47976806	47976806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47976806C>T	ENST00000543600.1	-	2	459	c.420G>A	c.(418-420)gtG>gtA	p.V140V	PTCHD4_ENST00000339488.4_Silent_p.V157V			Q6ZW05	CF138_HUMAN	patched domain containing 4	157						integral to membrane	hedgehog receptor activity										TTGGCACTTCCACTACCCCGC	0.478000													11	27					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130883776	130883776	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:130883776G>A	ENST00000509018.1	-	6	664	c.459C>T	c.(457-459)acC>acT	p.T153T	RAPGEF6_ENST00000296859.6_Silent_p.T153T|RAPGEF6_ENST00000308008.6_Silent_p.T153T|RAPGEF6_ENST00000307984.5_Silent_p.T153T|RAPGEF6_ENST00000510071.1_Silent_p.T153T|FNIP1_ENST00000514667.1_Silent_p.T203T|RAPGEF6_ENST00000507093.1_Silent_p.T153T	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	153					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CATCAGTAATGGTTTGGCGCT	0.333000													33	107					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179449180	179449180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179449180C>T	ENST00000589042.1	-	311	65322	c.65098G>A	c.(65098-65100)Gaa>Aaa	p.E21700K	TTN_ENST00000342992.6_Missense_Mutation_p.E19132K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E12635K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E12827K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E12760K|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E20059K|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20059							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTTTCTTTCCTTGCGTTCA	0.443000													28	65					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169783678	169783678	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169783678C>G	ENST00000263817.6	-	26	3730	c.3606G>C	c.(3604-3606)atG>atC	p.M1202I		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1202	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTGGGAGTGACATGACAAAAT	0.453000													18	181					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767944	57767944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57767944G>A	ENST00000371030.2	+	1	1870	c.1870G>A	c.(1870-1872)Ggg>Agg	p.G624R		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	624						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCAGGTGTACGGGGATGAGAC	0.607000													33	79					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96180974	96180974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:96180974C>T	ENST00000343702.4	-	2	776	c.328G>A	c.(328-330)Gag>Aag	p.E110K	NTN4_ENST00000538383.1_Missense_Mutation_p.E73K|NTN4_ENST00000553059.1_Missense_Mutation_p.E110K|NTN4_ENST00000344911.4_Missense_Mutation_p.E73K	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	110	Laminin N-terminal.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						TGCACATCCTCCGCAGACTGC	0.532000													18	46					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33840377	33840377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33840377C>T	ENST00000389232.4	+	9	857	c.787C>T	c.(787-789)Ctt>Ttt	p.L263F	RYR3_ENST00000415757.3_Missense_Mutation_p.L263F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	263	MIR 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGCCAGGTCTCTTTGGAGAGT	0.493000													10	16					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179561820	179561820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179561820G>A	ENST00000444136.1	+	2	320	c.70G>A	c.(70-72)Gat>Aat	p.D24N	TDRD5_ENST00000367614.1_Missense_Mutation_p.D24N|TDRD5_ENST00000294848.8_Missense_Mutation_p.D24N	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	24	Lotus/OST-HTH 1.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						TTCCACCAAAGATGGTTTGAG	0.483000													16	146					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141116507	141116507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:141116507G>A	ENST00000389484.3	-	73	12111	c.11140C>T	c.(11140-11142)Ctt>Ttt	p.L3714F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3714	LDL-receptor class A 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.L3714I(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GATGGACAAAGAAATTTGACT	0.368000										TSP Lung(27;0.18)			35	84					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185229469	185229469	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:185229469G>A	ENST00000296252.4	-	9	1252	c.1111C>T	c.(1111-1113)Cag>Tag	p.Q371*	LIPH_ENST00000424591.2_Nonsense_Mutation_p.Q337*	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	371					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TGATATTTCTGAAATGTGGTG	0.393000													28	80					0	0	1	0	0
AREG	374	broad.mit.edu	37	4	75312457	75312457	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:75312457G>A	ENST00000395748.3	+	2	480	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K	AREG_ENST00000502307.1_Missense_Mutation_p.E90K|AREG_ENST00000264487.2_Missense_Mutation_p.E90K	NM_001657.2	NP_001648.1	P15514	AREG_HUMAN	amphiregulin	90					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity			lung(4)	4			Lung(101;0.196)			GTATGATAACGAACCACAAAT	0.448000													35	80					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106431439	106431439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:106431439C>T	ENST00000407775.2	+	2	358	c.108C>T	c.(106-108)tcC>tcT	p.S36S	ZFPM2_ENST00000520492.1_5'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	36					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ACATCATCTCCAAAGGAGACT	0.408000													12	58					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62954404	62954404	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:62954404C>T	ENST00000393630.3	+	27	3937	c.3546C>T	c.(3544-3546)gaC>gaT	p.D1182D	MON2_ENST00000280379.6_Silent_p.D1182D|MON2_ENST00000552738.1_Silent_p.D1158D|MON2_ENST00000393629.2_Silent_p.D1181D|MON2_ENST00000393632.2_Silent_p.D1181D|MON2_ENST00000546600.1_Silent_p.D1181D	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	1182					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CTGTCAGAGACTCAGATAAGC	0.448000													33	57					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66436970	66436970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66436970C>T	ENST00000341529.3	+	12	2401	c.2253C>T	c.(2251-2253)tcC>tcT	p.S751S	CDH5_ENST00000539168.1_Silent_p.S190S	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	751	Ser-rich.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CCGACTCATCCGACTCTGACG	0.622000													9	26					0	0	1	0	0
C1orf216	127703	broad.mit.edu	37	1	36181917	36181917	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36181917G>A	ENST00000270815.4	-	2	776	c.6C>T	c.(4-6)ttC>ttT	p.F2F	C1orf216_ENST00000503824.1_5'UTR	NM_152374.1	NP_689587.1	Q8TAB5	CA216_HUMAN	chromosome 1 open reading frame 216	2										kidney(2)|lung(3)|skin(2)|urinary_tract(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GCTGGATGGCGAACATCTAGC	0.582000											OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	19					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3212029	3212029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3212029G>A	ENST00000380059.3	-	8	1125	c.1024C>T	c.(1024-1026)Ccg>Tcg	p.P342S	SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Missense_Mutation_p.P299S|SLC4A11_ENST00000380056.3_Missense_Mutation_p.P315S	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	315					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						TTCGTTCTCGGCGCCACTGGA	0.662000													25	53					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68160436	68160436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68160436C>T	ENST00000349223.5	+	3	1548	c.1324C>T	c.(1324-1326)Cat>Tat	p.H442Y	NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.H442Y|NFATC3_ENST00000329524.4_Missense_Mutation_p.H442Y|NFATC3_ENST00000575270.1_Missense_Mutation_p.H442Y	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	442	RHD.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		ACCTAAAACTCATCATCGAGC	0.438000													35	60					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50283263	50283263	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50283263C>T	ENST00000320634.3	-	9	746		c.e9+1		FAIM2_ENST00000550890.1_Splice_Site	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2						anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						CCAGAGCTGACCTTGGTCTGG	0.657000													4	57					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91744422	91744422	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91744422G>A	ENST00000389857.6	-	29	4988	c.4902C>T	c.(4900-4902)ccC>ccT	p.P1634P	CCDC88C_ENST00000331194.7_Silent_p.P158P	NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1634					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TCCGAGGCAAGGGGTACTCGT	0.701000													7	12					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17317979	17317979	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17317979C>T	ENST00000595618.1	+	35	5702	c.5550C>T	c.(5548-5550)ttC>ttT	p.F1850F	CTD-3032J10.3_ENST00000601929.1_RNA|MYO9B_ENST00000594824.1_Silent_p.F1850F|MYO9B_ENST00000397274.2_Silent_p.F1850F	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1850	Rho-GAP.|Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						CCATTATCTTCGCACCCTGCC	0.647000													5	4					0	0	1	0	0
PANX3	116337	broad.mit.edu	37	11	124489364	124489364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124489364G>A	ENST00000284288.2	+	4	779	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3	238					protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CTTCTTCCAGGAAGAATTCAG	0.498000													15	36					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56232592	56232592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56232592C>T	ENST00000268912.5	+	1	99	c.78C>T	c.(76-78)ttC>ttT	p.F26F		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TCCAGAAATTCCTGTTCCTTC	0.478000													66	162					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40412184	40412184	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40412184G>A	ENST00000221347.6	-	7	3451	c.3444C>T	c.(3442-3444)ggC>ggT	p.G1148G		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1148	Cys-rich.|TIL 2.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACAGCGGGCAGCCGTAGGAAC	0.612000													16	55					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4872438	4872438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4872438G>A	ENST00000252318.2	+	8	1716	c.1379G>A	c.(1378-1380)gGa>gAa	p.G460E		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	460						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						ATAGATTTTGGAGACGTTTCT	0.398000													12	79					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54574665	54574665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54574665C>T	ENST00000336470.4	+	9	773	c.634C>T	c.(634-636)Cgt>Tgt	p.R212C	GNL3L_ENST00000360845.2_Missense_Mutation_p.R212C	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	212					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						TTTCCAGAATCGTTGCAGTGT	0.478000													9	5					0	0	1	0	0
CPEB1	64506	broad.mit.edu	37	15	83218215	83218215	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83218215G>A	ENST00000563800.1	-	9	3200	c.1475C>T	c.(1474-1476)cCc>cTc	p.P492L	CPEB1_ENST00000568757.1_Missense_Mutation_p.P390L|CPEB1_ENST00000568128.1_Missense_Mutation_p.P465L|CPEB1_ENST00000562019.1_Missense_Mutation_p.P470L|CPEB1_ENST00000423133.2_Missense_Mutation_p.P390L|CPEB1_ENST00000398591.2_Missense_Mutation_p.P395L|CPEB1_ENST00000398592.2_Missense_Mutation_p.P239L|CPEB1_ENST00000450751.2_Missense_Mutation_p.P390L|CPEB1_ENST00000261723.6_Missense_Mutation_p.P468L|RP11-152F13.10_ENST00000562833.1_Missense_Mutation_p.P200S|RP11-379H8.1_ENST00000568285.1_Intron|CPEB1_ENST00000564522.1_Missense_Mutation_p.P390L			Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding protein 1	470	Necessary for stress granule assembly and correct localization in dcp1 bodies.|RRM 2.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(1)|skin(1)	28			BRCA - Breast invasive adenocarcinoma(143;0.229)			CTTACCAATGGGATACTTGTG	0.522000													17	56					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891650	5891650	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:5891650C>T	ENST00000581347.1	-	3	1058	c.413G>A	c.(412-414)cGa>cAa	p.R138Q	TMEM200C_ENST00000383490.2_Missense_Mutation_p.R138Q|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	138						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						GGAGGCGGCTCGTGCTGGAGG	0.652000													12	50					0	0	1	0	0
ENTPD2	954	broad.mit.edu	37	9	139944958	139944958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139944958G>A	ENST00000355097.2	-	6	854	c.807C>T	c.(805-807)ggC>ggT	p.G269G	ENTPD2_ENST00000312665.5_Silent_p.G269G	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	269						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGGTGGAAAAGCCCCTCGGCC	0.642000											OREG0019627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	22					0	0	1	0	0
POTED	317754	broad.mit.edu	37	21	15013746	15013746	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:15013746G>A	ENST00000299443.5	+	11	1666	c.1614G>A	c.(1612-1614)ctG>ctA	p.L538L		NM_174981.3|NM_207355.2	NP_778146.2|NP_997238.2	Q86YR6	POTED_HUMAN	POTE ankyrin domain family, member D	538						plasma membrane				central_nervous_system(1)|large_intestine(10)|liver(2)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	33						TGCTAAGACTGGAACTAGATG	0.363000													25	26					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57481086	57481086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57481086G>A	ENST00000371236.2	-	12	1177	c.914C>T	c.(913-915)gCt>gTt	p.A305V	DAB1_ENST00000371231.1_Missense_Mutation_p.A338V|DAB1_ENST00000439789.2_Missense_Mutation_p.A219V|DAB1_ENST00000371234.4_Missense_Mutation_p.A305V|DAB1_ENST00000420954.2_Missense_Mutation_p.A303V|DAB1_ENST00000414851.2_Missense_Mutation_p.A287V|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	338					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						CGGGAGGACAGCGCCCATTGC	0.582000													14	25					0	0	1	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333369	28333369	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:28333369C>T	ENST00000377255.3	+	7	1221	c.924C>T	c.(922-924)gcC>gcT	p.A308A	ZKSCAN3_ENST00000252211.2_Silent_p.A308A|ZKSCAN3_ENST00000341464.5_Silent_p.A160A	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	308					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						AGAAAAATGCCACAGGAGGGA	0.502000													20	53					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53418996	53418996	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:53418996C>T	ENST00000377942.3	-	3	3115	c.2912G>A	c.(2911-2913)gGg>gAg	p.G971E	PCDH8_ENST00000338862.4_Missense_Mutation_p.G874E	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	971					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding	p.G971V(1)		breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TGCGTTGGGCCCGCTGCAGGA	0.582000													10	39					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103352543	103352543	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103352543C>T	ENST00000358392.2	-	63	5031	c.4714G>A	c.(4714-4716)Ggc>Agc	p.G1572S	COL11A1_ENST00000370096.3_Missense_Mutation_p.G1560S|COL11A1_ENST00000512756.1_Missense_Mutation_p.G1444S|COL11A1_ENST00000353414.4_Missense_Mutation_p.G1521S	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1560					collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.G1560C(1)|p.G1572C(1)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTTGCATGCCTTCAGTATGT	0.393000													48	127					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88284438	88284438	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:88284438G>A	ENST00000357081.3	-	8	768	c.624C>T	c.(622-624)atC>atT	p.I208I	AGTPBP1_ENST00000337006.4_Silent_p.I150I|AGTPBP1_ENST00000376109.3_Silent_p.I260I|AGTPBP1_ENST00000376080.1_Silent_p.I150I|AGTPBP1_ENST00000376083.3_Silent_p.I208I|AGTPBP1_ENST00000491784.1_5'UTR|AGTPBP1_ENST00000432218.1_Silent_p.I46I|AGTPBP1_ENST00000376081.4_Silent_p.I208I			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	208					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						ATGGTCCAATGATTTTAAACA	0.348000													8	90					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114641717	114641717	+	Splice_Site	SNP	G	G	A	rs149899868		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114641717G>A	ENST00000393296.1	-	5	1440	c.1364_splice	c.e5+1	p.R455_splice	SYT6_ENST00000369547.1_Splice_Site_p.R370_splice			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	455	C2 2.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCTACCTACCGATCATAGTCC	0.512000													45	92					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156749	22156749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22156749G>A	ENST00000397126.4	-	4	1235	c.1087C>T	c.(1087-1089)Cat>Tat	p.H363Y	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTCCAGTATGAATTACCTTA	0.388000													22	48					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107858195	107858195	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107858195G>A	ENST00000328300.6	+	30	2694	c.2450G>A	c.(2449-2451)gGa>gAa	p.G817E	COL4A5_ENST00000361603.2_Missense_Mutation_p.G817E	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	817	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGGCTGCCAGGAATAGGTGTT	0.438000									Alport syndrome with Diffuse Leiomyomatosis				24	14					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27939826	27939826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27939826C>T	ENST00000374005.3	-	12	1573	c.1285G>A	c.(1285-1287)Gct>Act	p.A429T	FGR_ENST00000399173.1_Missense_Mutation_p.A429T|FGR_ENST00000374004.1_Missense_Mutation_p.A429T|FGR_ENST00000545953.1_Missense_Mutation_p.A363T	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	429	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AAGAGGGCAGCTTCTGGGGCT	0.547000													12	120					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1459935	1459935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1459935G>A	ENST00000345913.4	+	7	791	c.700G>A	c.(700-702)Gga>Aga	p.G234R	TPO_ENST00000382198.1_Missense_Mutation_p.G234R|TPO_ENST00000349624.3_Missense_Mutation_p.G234R|TPO_ENST00000329066.4_Missense_Mutation_p.G234R|TPO_ENST00000497517.2_Intron|TPO_ENST00000382201.3_Missense_Mutation_p.G234R|TPO_ENST00000337415.3_Missense_Mutation_p.G234R|TPO_ENST00000346956.3_Missense_Mutation_p.G234R	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	234					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GATGGCATGGGGACAATACAT	0.522000													11	28					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933552	44933552	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44933552C>T	ENST00000291187.4	-	6	1708	c.1386G>A	c.(1384-1386)aaG>aaA	p.K462K	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Silent_p.K468K	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				AGCTGAATCCCTTTCCACACT	0.552000													19	58					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815650	158815650	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158815650G>A	ENST00000368141.4	+	5	1105	c.844G>A	c.(844-846)Gaa>Aaa	p.E282K		NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	282	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					GGAAATAAAGGAAGCATCATC	0.338000													24	72					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733510	152733510	+	Silent	SNP	G	G	A	rs138516775		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152733510G>A	ENST00000368773.1	+	2	1504	c.1446G>A	c.(1444-1446)ccG>ccA	p.P482P	KPRP_ENST00000606109.1_Silent_p.P482P	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	482	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCCCTGCCGGCGCCCTGCC	0.657000													41	95					0	0	1	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55610167	55610167	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55610167G>A	ENST00000263433.3	-	6	951	c.936C>T	c.(934-936)gcC>gcT	p.A312A	PPP1R12C_ENST00000376393.2_Silent_p.A312A|PPP1R12C_ENST00000435544.2_Silent_p.A238A	NM_001271618.1|NM_017607.2	NP_001258547.1|NP_060077.1	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	312						cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	22			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CCTGTTTCCGGGCCAGTTCCT	0.637000													19	51					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47384223	47384223	+	Missense_Mutation	SNP	C	C	T	rs71737295		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47384223C>T	ENST00000232766.5	+	9	1261	c.1241C>T	c.(1240-1242)aCc>aTc	p.T414I	KLHL18_ENST00000455924.2_Missense_Mutation_p.T302I	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	414										endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		ACAGTGGTGACCTCGATGAGC	0.507000													18	48					0	0	1	0	0
LZTS3	9762	broad.mit.edu	37	20	3147736	3147736	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3147736G>A	ENST00000329152.3	-	1	1471	c.74C>T	c.(73-75)cCc>cTc	p.P25L	LZTS3_ENST00000360342.3_Missense_Mutation_p.P25L|LZTS3_ENST00000337576.5_Missense_Mutation_p.P25L	NM_014731.2	NP_055546.1																					AAGCTCGGAGGGCCGTGGGGC	0.701000													3	2					0	0	1	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16734107	16734107	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:16734107C>T	ENST00000297967.5	+	1	207	c.108C>T	c.(106-108)ttC>ttT	p.F36F	NLGN4Y_ENST00000476359.1_3'UTR	NM_001164238.1	NP_001157710.1	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked	36					brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity			large_intestine(3)|lung(7)|prostate(2)|skin(2)	14						CCATCAAGTTCACCCTCATTG	0.468000													30	31					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70933777	70933777	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:70933777G>A	ENST00000334414.6	-	24	5664	c.5620C>T	c.(5620-5622)Cgt>Tgt	p.R1874C	PTPRB_ENST00000550857.1_Missense_Mutation_p.R1566C|PTPRB_ENST00000451516.2_Missense_Mutation_p.R1566C|PTPRB_ENST00000550358.1_Missense_Mutation_p.R1786C|PTPRB_ENST00000538708.1_Missense_Mutation_p.R1566C|PTPRB_ENST00000261266.5_Missense_Mutation_p.R1656C	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1656	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATGCTCAGACGGGCAGAGGGT	0.418000													10	31					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065757	35065757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35065757C>T	ENST00000382002.5	-	10	1729	c.1303G>A	c.(1303-1305)Gat>Aat	p.D435N	PRLR_ENST00000513753.1_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.D334N|PRLR_ENST00000511486.1_Missense_Mutation_p.D334N|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	435					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TCACACACATCAGTAATATTG	0.483000													27	173					0	0	1	0	0
CLCN4	1183	broad.mit.edu	37	X	10176240	10176240	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:10176240C>T	ENST00000380833.4	+	9	1390	c.999C>T	c.(997-999)ttC>ttT	p.F333F	CLCN4_ENST00000380829.1_Intron|CLCN4_ENST00000421085.2_Silent_p.F239F	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	333						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CTGAACTCTTCCCCTTCATCC	0.572000													65	54					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58067416	58067416	+	Silent	SNP	C	C	T	rs80356507		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58067416C>T	ENST00000357272.4	+	4	865	c.700C>T	c.(700-702)Ctg>Ttg	p.L234L	FLNB_ENST00000358537.3_Silent_p.L234L|FLNB_ENST00000295956.4_Silent_p.L234L|FLNB_ENST00000429972.2_Silent_p.L234L|FLNB_ENST00000490882.1_Silent_p.L234L|FLNB_ENST00000348383.5_Silent_p.L234L|FLNB_ENST00000419752.2_Silent_p.L65L|FLNB_ENST00000493452.1_Silent_p.L65L			O75369	FLNB_HUMAN	filamin B, beta	234	Actin-binding.|CH 2.		L -> V (in LRS1).		actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TATGACTTACCTGTCCCAGTT	0.527000													12	136					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800898	21800898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21800898C>T	ENST00000443632.2	+	2	2086	c.1714C>T	c.(1714-1716)Cgt>Tgt	p.R572C	HIC2_ENST00000407464.2_Missense_Mutation_p.R572C|HIC2_ENST00000407598.2_Missense_Mutation_p.R572C			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	572					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GCGCTTCACCCGTCAGTACCG	0.627000													13	56					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22364016	22364016	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22364016G>A	ENST00000397121.2	-	3	820	c.503C>T	c.(502-504)tCc>tTc	p.S168F		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ACATTTGTAGGAATTCTCTCT	0.338000													37	82					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13107074	13107074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:13107074C>T	ENST00000319217.7	-	47	6350	c.6103G>A	c.(6103-6105)Gat>Aat	p.D2035N	MPDZ_ENST00000541718.1_Missense_Mutation_p.D2006N|MPDZ_ENST00000447879.1_Missense_Mutation_p.D2002N|MPDZ_ENST00000381015.4_Missense_Mutation_p.D2035N|MPDZ_ENST00000541093.1_Missense_Mutation_p.D269N|MPDZ_ENST00000536827.1_Missense_Mutation_p.D1973N|MPDZ_ENST00000538841.1_Missense_Mutation_p.D894N|MPDZ_ENST00000381022.2_Missense_Mutation_p.D2006N|MPDZ_ENST00000546205.1_Missense_Mutation_p.D2049N	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	2035	PDZ 13.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		ATGATCTGATCGCCCCTTTTC	0.448000													22	138					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3670728	3670728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3670728G>A	ENST00000344754.4	-	18	4774	c.4775C>T	c.(4774-4776)tCc>tTc	p.S1592F	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.S1592F	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1592	Ig-like C2-type 16.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGCATTGGGGGAAGCCAGGAC	0.632000													5	15					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16199342	16199342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16199342C>T	ENST00000375759.3	+	2	319	c.115C>T	c.(115-117)Ccc>Tcc	p.P39S		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	39	RRM 1.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CAAAATTCTTCCCAAGAGGGG	0.398000													27	65					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070073	9070073	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9070073C>T	ENST00000397910.4	-	3	17576	c.17373G>A	c.(17371-17373)gaG>gaA	p.E5791E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5793	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTTGATCTCCTCAGACGTCC	0.458000													25	50					0	0	1	0	0
PIP	5304	broad.mit.edu	37	7	142836648	142836648	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142836648G>A	ENST00000291009.3	+	4	394	c.354G>A	c.(352-354)cgG>cgA	p.R118R		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	118						extracellular region	actin binding	p.R118R(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		ATGTTATTCGGGAATTAGGCA	0.453000													66	141					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25255686	25255686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25255686G>A	ENST00000400358.4	+	9	862	c.805G>A	c.(805-807)Gac>Aac	p.D269N	SGSM1_ENST00000400359.4_Missense_Mutation_p.D269N	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	269						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						TCTGCAGAGGGACGACATGGA	0.557000													27	42					0	0	1	0	0
DCTN3	11258	broad.mit.edu	37	9	34614060	34614060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34614060G>A	ENST00000259632.7	-	6	465	c.450C>T	c.(448-450)ctC>ctT	p.L150L	DCTN3_ENST00000447983.2_3'UTR|DCTN3_ENST00000341694.2_3'UTR|DCTN3_ENST00000378916.4_Silent_p.L122L|DCTN3_ENST00000479399.1_5'UTR|DCTN3_ENST00000477738.2_Intron	NM_007234.3	NP_009165.1	O75935	DCTN3_HUMAN	dynactin 3 (p22)	150					cytokinesis|G2/M transition of mitotic cell cycle|mitosis	centrosome|cleavage furrow|condensed chromosome kinetochore|cytosol|dynactin complex|midbody|perinuclear region of cytoplasm|spindle	protein binding|structural molecule activity			large_intestine(1)|skin(1)	2	all_epithelial(49;0.0863)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.0388)		ATTCCTCCAGGAGAGCCTTGG	0.498000													36	70					0	0	1	0	0
MS4A6E	245802	broad.mit.edu	37	11	60105331	60105331	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60105331G>A	ENST00000300182.4	+	2	330	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K		NM_139249.2	NP_640342.1	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member 6E	89						integral to membrane	receptor activity	p.E89K(1)		endometrium(2)|kidney(1)|lung(9)|stomach(1)	13						TAAGTTGGACGAAAAGGATAT	0.453000													53	102					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94898020	94898020	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94898020G>A	ENST00000289495.5	+	11	2973		c.e11+1		PPP1R9A_ENST00000340694.4_Splice_Site|PPP1R9A_ENST00000424654.1_Splice_Site|PPP1R9A_ENST00000456331.2_Splice_Site|PPP1R9A_ENST00000433881.1_Splice_Site|PPP1R9A_ENST00000433360.1_Splice_Site	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A							cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGAGAGAAAGGTGAGCACCCT	0.443000										HNSCC(28;0.073)			15	50					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127379290	127379290	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127379290C>T	ENST00000342480.6	+	3	458	c.419C>T	c.(418-420)cCa>cTa	p.P140L		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	140					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						CAAGAGCTGCCAAACCTCCCC	0.498000													14	64					0	0	1	0	0
BASP1	10409	broad.mit.edu	37	5	17275909	17275909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:17275909C>T	ENST00000322611.3	+	2	844	c.584C>T	c.(583-585)tCc>tTc	p.S195F		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	195					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						GCGCCTAGTTCCACACCCAAG	0.642000													5	40					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60558971	60558971	+	Missense_Mutation	SNP	G	G	A	rs141490536	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:60558971G>A	ENST00000373886.3	+	12	1688	c.1684G>A	c.(1684-1686)Gaa>Aaa	p.E562K	BICC1_ENST00000263103.1_Missense_Mutation_p.E188K	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	562					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						TATGCAGACCGAAGGCAAAAA	0.468000													7	23					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78789991	78789991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78789991C>T	ENST00000545128.1	+	14	2384	c.1846C>T	c.(1846-1848)Cgc>Tgc	p.R616C	PCSK5_ENST00000376752.4_Missense_Mutation_p.R616C|PCSK5_ENST00000376767.3_Missense_Mutation_p.R616C	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	616					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GGAACGGTTCCGCTATAGCCG	0.488000													35	83					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206305266	206305266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206305266C>T	ENST00000406610.2	+	20	3121	c.2914C>T	c.(2914-2916)Cca>Tca	p.P972S	PARD3B_ENST00000349953.3_Intron|PARD3B_ENST00000351153.1_Missense_Mutation_p.P903S|PARD3B_ENST00000358768.2_Missense_Mutation_p.P910S	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	972					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CTTTAGATCTCCATCTCCCCC	0.483000													60	97					0	0	1	0	0
ATP2B4	493	broad.mit.edu	37	1	203681213	203681213	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:203681213C>T	ENST00000357681.5	+	13	3280	c.2157C>T	c.(2155-2157)ttC>ttT	p.F719F	ATP2B4_ENST00000391954.2_Silent_p.F719F|ATP2B4_ENST00000367218.3_Silent_p.F719F|ATP2B4_ENST00000341360.2_Silent_p.F719F|ATP2B4_ENST00000367219.3_Silent_p.F707F	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	719					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GGGATGACTTCCTGTGCTTAG	0.532000													27	91					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61949998	61949998	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61949998G>A	ENST00000336844.5	-	4	546	c.395C>T	c.(394-396)tCg>tTg	p.S132L	CSH2_ENST00000560142.1_Missense_Mutation_p.S75L|CSH2_ENST00000392886.2_Missense_Mutation_p.S132L|CSH2_ENST00000345366.7_Intron	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	132					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						ATCGCTGTCCGAGGTGTCATA	0.597000													29	64					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70281924	70281924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:70281924C>T	ENST00000377844.4	-	10	2779	c.2020G>A	c.(2020-2022)Gat>Aat	p.D674N	KLHL1_ENST00000545028.1_Missense_Mutation_p.D481N	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	674					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GTTTTGGGATCATATCTAAAA	0.368000													13	51					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129180	6129180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6129180G>A	ENST00000316529.3	+	1	267	c.172G>A	c.(172-174)Gag>Aag	p.E58K		NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATTCAACATGAGACCGTGCT	0.522000													23	44					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56243414	56243414	+	Missense_Mutation	SNP	G	G	A	rs143466064		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56243414G>A	ENST00000332836.2	-	2	1810	c.1783C>T	c.(1783-1785)Cgc>Tgc	p.R595C		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	595						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ACACACATGCGAAGTGTCGTT	0.393000													15	63					0	0	1	0	0
NR0B1	190	broad.mit.edu	37	X	30327363	30327363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:30327363C>T	ENST00000378970.4	-	1	352	c.118G>A	c.(118-120)Ggc>Agc	p.G40S	NR0B1_ENST00000453287.1_Missense_Mutation_p.G40S	NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	40	4 X 67 AA tandem repeats.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	CACGAACAGCCCCAGCACTGA	0.657000													4	7					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560363	44560363	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44560363C>T	ENST00000332567.4	-	1	1625	c.1273G>A	c.(1273-1275)Gat>Aat	p.D425N	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	425					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TTAGCCGAATCCCAGGACTCA	0.547000													41	98					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126226912	126226912	+	Silent	SNP	C	C	T	rs139167502	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126226912C>T	ENST00000290868.2	-	5	491	c.438G>A	c.(436-438)tcG>tcA	p.S146S	UROC1_ENST00000383579.3_Silent_p.S146S	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	146					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CTGTCATCTTCGACAAGTAGA	0.587000													21	134					0	0	1	0	0
KIAA0196	9897	broad.mit.edu	37	8	126091028	126091028	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:126091028G>A	ENST00000318410.7	-	6	1012	c.663C>T	c.(661-663)ttC>ttT	p.F221F	KIAA0196_ENST00000517845.1_Silent_p.F73F	NM_014846.3	NP_055661.3	Q12768	STRUM_HUMAN	KIAA0196	221					cell death	WASH complex				NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	42	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CCATACTGATGAAGGATTCGT	0.413000													29	80					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2542543	2542543	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2542543C>T	ENST00000358864.1	+	4	456	c.441C>T	c.(439-441)tcC>tcT	p.S147S		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	147	Arg/Asp/Glu/Lys-rich (highly charged).					integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						GTGGGGAGTCCCTGTCCGAGG	0.612000													24	65					0	0	1	0	0
RTP1	132112	broad.mit.edu	37	3	186917640	186917640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186917640G>A	ENST00000312295.4	+	2	604	c.574G>A	c.(574-576)Gag>Aag	p.E192K	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	192					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		AGAGTTCTGCGAGGCCTGCCA	0.701000													12	32					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179526210	179526210	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:179526210C>T	ENST00000467460.1	-	13	1698	c.1368G>A	c.(1366-1368)ggG>ggA	p.G456G	PEX5L_ENST00000485199.1_Silent_p.G421G|PEX5L_ENST00000476138.1_Silent_p.G413G|PEX5L_ENST00000465751.1_Silent_p.G432G|PEX5L_ENST00000472994.1_Silent_p.G397G|PEX5L_ENST00000468741.1_Silent_p.G264G|PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000464614.1_Silent_p.G348G|PEX5L_ENST00000392649.3_Silent_p.G348G|PEX5L_ENST00000263962.8_Silent_p.G454G	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	456					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			ATTCCTTCACCCCTTCCAGAA	0.398000													33	81					0	0	1	0	0
MYLK2	85366	broad.mit.edu	37	20	30418653	30418653	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30418653G>A	ENST00000375994.2	+	8	1529	c.1256G>A	c.(1255-1257)gGg>gAg	p.G419E	MYLK2_ENST00000468730.1_3'UTR|MYLK2_ENST00000375985.4_Missense_Mutation_p.G419E			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	419	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AACACCACCGGGCATTTGGTG	0.627000													83	215					0	0	1	0	0
RCBTB1	55213	broad.mit.edu	37	13	50115837	50115837	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:50115837G>A	ENST00000378302.2	-	11	1559	c.1299C>T	c.(1297-1299)gtC>gtT	p.V433V	RCBTB1_ENST00000258646.3_Silent_p.V433V	NM_018191.3	NP_060661.3	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	433	BTB 1.				cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|urinary_tract(1)	16		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		GCGGCAGGTCGACTGTGTCTG	0.458000													30	50					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61894123	61894123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61894123G>A	ENST00000280772.1	-	25	2938	c.2747C>T	c.(2746-2748)tCc>tTc	p.S916F	ANK3_ENST00000503366.1_Missense_Mutation_p.S917F|ANK3_ENST00000373827.2_Missense_Mutation_p.S910F|ANK3_ENST00000355288.2_Missense_Mutation_p.S50F	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	916					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CGAACTGAAGGAGCGGAGGCT	0.418000													12	28					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55823374	55823374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55823374C>T	ENST00000309383.1	+	19	2552	c.2275C>T	c.(2275-2277)Ccc>Tcc	p.P759S	BRSK1_ENST00000590333.1_Missense_Mutation_p.P775S|BRSK1_ENST00000326848.7_Missense_Mutation_p.P454S	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	759					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GAGCAGCTCTCCCCGCCGAGG	0.741000													5	7					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14747289	14747289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:14747289G>A	ENST00000380881.4	-	34	6800	c.5985C>T	c.(5983-5985)tcC>tcT	p.S1995S	FREM1_ENST00000380894.1_Silent_p.S530S|FREM1_ENST00000422223.2_Silent_p.S1994S|FREM1_ENST00000380880.3_Silent_p.S1994S			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1994					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGTCAGTTGTGGATTCCACCT	0.423000													40	131					0	0	1	0	0
IGKV1D-17	28900	broad.mit.edu	37	2	90121694	90121694	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:90121694C>T	ENST00000483379.1	+	0	218																											CCTGGGGCTCCTGCTGCTCTG	0.507000													25	140					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117278829	117278829	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:117278829C>T	ENST00000355044.3	+	25	3837	c.3711C>T	c.(3709-3711)ttC>ttT	p.F1237F	ATRNL1_ENST00000303745.7_Silent_p.F30F|ATRNL1_ENST00000423111.2_Silent_p.F288F	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1237						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TTGTCACCTTCTTCAGGTAAA	0.323000													9	36					0	0	1	0	0
OR4S1	256148	broad.mit.edu	37	11	48328209	48328209	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48328209C>T	ENST00000319988.1	+	1	435	c.435C>T	c.(433-435)gcC>gcT	p.A145A		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						TAGCGGGGGCCTCCTGGTTAG	0.562000													41	43					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670531	49670531	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:49670531C>T	ENST00000561648.1	-	4	2585	c.2532G>A	c.(2530-2532)ggG>ggA	p.G844G	ZNF423_ENST00000567169.1_Silent_p.G727G|ZNF423_ENST00000535559.1_Silent_p.G727G|ZNF423_ENST00000563137.2_Silent_p.G784G|ZNF423_ENST00000562520.1_Silent_p.G784G|ZNF423_ENST00000262383.2_Silent_p.G844G|ZNF423_ENST00000562871.1_Silent_p.G784G	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	844					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TTGGGGGTACCCCATTGGCCG	0.597000													10	27					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34549924	34549924	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34549924G>A	ENST00000354181.3	-	6	1101	c.609C>T	c.(607-609)atC>atT	p.I203I	SLC12A6_ENST00000451844.2_Intron|SLC12A6_ENST00000558589.1_Silent_p.I194I|SLC12A6_ENST00000560164.1_Intron|SLC12A6_ENST00000397707.2_Silent_p.I188I|SLC12A6_ENST00000397702.2_Silent_p.I144I|SLC12A6_ENST00000560611.1_Silent_p.I203I|SLC12A6_ENST00000458406.2_Silent_p.I144I|SLC12A6_ENST00000558667.1_Silent_p.I203I|SLC12A6_ENST00000290209.5_Silent_p.I152I|RP11-1084A12.2_ENST00000559867.1_RNA			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	203					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GTAAAAAAAGGATCACTCCAA	0.443000													8	28					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27151149	27151149	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27151149G>A	ENST00000288699.6	+	5	785	c.627G>A	c.(625-627)ggG>ggA	p.G209G	DPYSL5_ENST00000401478.1_Silent_p.G209G	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	209					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGATTTGGGGATCACAGGCC	0.478000													11	36					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157803146	157803146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157803146G>A	ENST00000368174.4	-	5	971	c.875C>T	c.(874-876)tCt>tTt	p.S292F		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	292	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GAAGGAGGGAGAGAGGGACTT	0.587000													15	125					0	0	1	0	0
NPBWR1	2831	broad.mit.edu	37	8	53852583	53852583	+	Missense_Mutation	SNP	C	C	T	rs145057890		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:53852583C>T	ENST00000331251.3	+	1	1593	c.116C>T	c.(115-117)gCt>gTt	p.A39V		NM_005285.3	NP_005276.2	P48145	NPBW1_HUMAN	neuropeptides B/W receptor 1	39					synaptic transmission	plasma membrane	opioid receptor activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)	17		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				CTGGCGGTGGCTGTACCAGTT	0.716000													11	22					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138633391	138633391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:138633391G>A	ENST00000218099.2	+	6	698	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K	F9_ENST00000394090.2_Missense_Mutation_p.E193K	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	231	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGTTGGTGGAGAAGATGCCAA	0.453000													41	23					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107019899	107019899	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:107019899C>T	ENST00000369063.3	-	9	1628	c.1163G>A	c.(1162-1164)cGa>cAa	p.R388Q	RTN4IP1_ENST00000539449.1_3'UTR|RTN4IP1_ENST00000498091.1_5'UTR	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	388						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		AGTCTTTCCTCGTGCGTGTCC	0.383000													22	34					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48684206	48684206	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48684206G>A	ENST00000544264.1	-	22	7580	c.7300C>T	c.(7300-7302)Cga>Tga	p.R2434*	CELSR3_ENST00000164024.4_Nonsense_Mutation_p.R2429*			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2429					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTGGCACCTCGGCGTTCTGCC	0.592000													8	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179489358	179489358	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179489358C>T	ENST00000589042.1	-	242	44873	c.44649G>A	c.(44647-44649)gtG>gtA	p.V14883V	TTN_ENST00000342992.6_Silent_p.V12315V|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Silent_p.V5818V|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.V6010V|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Silent_p.V5943V|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.V13242V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13242	Fibronectin type-III 7.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAACCATTTCACCTTAGCAT	0.458000													24	58					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6650760	6650760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6650760G>A	ENST00000299441.3	-	12	5495	c.5084C>T	c.(5083-5085)tCt>tTt	p.S1695F		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1695	Cadherin 16.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGATCCAGAGAAAAGCTTTC	0.547000													6	16					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71152304	71152304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71152304C>T	ENST00000355527.3	-	6	871	c.595G>A	c.(595-597)Ggc>Agc	p.G199S	DHCR7_ENST00000407721.2_Missense_Mutation_p.G199S	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	199					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	AAGAAGTAGCCCTTGACCATG	0.567000									Smith-Lemli-Opitz syndrome				21	63					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40599853	40599853	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40599853G>A	ENST00000260402.3	-	1	270	c.21C>T	c.(19-21)gtC>gtT	p.V7V	PLCB2_ENST00000456256.2_Silent_p.V7V|PLCB2_ENST00000557821.1_Silent_p.V7V|PLCB2_ENST00000543785.2_Silent_p.V7V	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	7					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GGGGCAGCAGGACAGGGTTGA	0.607000													11	52					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13663341	13663341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13663341G>A	ENST00000404922.3	+	9	2341	c.2222G>A	c.(2221-2223)gGa>gAa	p.G741E	FBLN2_ENST00000295760.7_Intron|FBLN2_ENST00000535798.1_Intron|FBLN2_ENST00000492059.1_Missense_Mutation_p.G741E	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	741	EGF-like 3; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AACACCCTGGGATCCTTCTAC	0.587000													17	42					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43756497	43756497	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:43756497C>T	ENST00000458276.2	+	5	843	c.720C>T	c.(718-720)ttC>ttT	p.F240F		NM_016006.4	NP_057090.2	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	240					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			kidney(3)|large_intestine(2)|liver(2)|lung(5)|ovary(1)|skin(1)	14		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		CTTCAATGTTCGAAGACGATA	0.368000													17	192					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101295475	101295475	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101295475G>A	ENST00000538618.1	+	4	410	c.410G>A	c.(409-411)cGg>cAg	p.R137Q	ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000392977.3_5'UTR|ANO4_ENST00000299222.9_5'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						ATCCATCAACGGCGAAGTGTG	0.502000										HNSCC(74;0.22)			9	60					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110763690	110763690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:110763690G>A	ENST00000451085.1	+	4	1908	c.862G>A	c.(862-864)Gag>Aag	p.E288K	IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000450877.1_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.E288K|LRRN3_ENST00000422987.3_Missense_Mutation_p.E288K	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	288						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ACACTTAAAAGAGTTGGGGAT	0.333000													38	85					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124311371	124311371	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124311371G>A	ENST00000409039.3	+	24	3988	c.3963G>A	c.(3961-3963)ttG>ttA	p.L1321L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1321	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CCTACTACTTGGAAGCAAAAA	0.453000													40	60					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220479908	220479908	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220479908C>T	ENST00000456909.1	+	24	3052	c.2962C>T	c.(2962-2964)Cct>Tct	p.P988S	STK11IP_ENST00000295641.10_Missense_Mutation_p.P999S			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	999					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGAGCCCTCTCCTCCAGCAGC	0.657000													8	16					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43322566	43322566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43322566G>A	ENST00000361428.2	-	4	2583	c.2506C>T	c.(2506-2508)Cgt>Tgt	p.R836C	ZNF318_ENST00000318149.3_Missense_Mutation_p.R836C	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	836					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GGGATCACACGAAGATTGGGA	0.527000													11	101					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017356	93017356	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:93017356C>T	ENST00000523629.1	-	6	1182	c.728G>A	c.(727-729)cGa>cAa	p.R243Q	RUNX1T1_ENST00000521553.1_Missense_Mutation_p.R206Q|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.R254Q|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.R206Q|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.R216Q|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.R206Q|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.R243Q|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.R206Q|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.R216Q	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	243					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R206Q(1)|p.R254Q(1)|p.R243L(1)|p.R243Q(1)|p.R254L(1)|p.R206L(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GTCTGGAGTTCGCCTCTTCCC	0.522000													21	113					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197596851	197596851	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197596851C>T	ENST00000389175.4	+	27	3299	c.3164C>T	c.(3163-3165)tCt>tTt	p.S1055F	CCDC150_ENST00000272831.7_Missense_Mutation_p.S702F|CCDC150_ENST00000409270.1_Missense_Mutation_p.S542F	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	1055										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CAGAGGCCTTCTGGGGAAGAC	0.423000													22	73					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171247961	171247961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171247961G>A	ENST00000354841.4	+	4	709	c.578G>A	c.(577-579)gGa>gAa	p.G193E	FMO1_ENST00000402921.2_Missense_Mutation_p.G130E|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.G193E			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	193					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTGGAATGGGAAATTCTGGC	0.433000													12	54					0	0	1	0	0
KCTD4	386618	broad.mit.edu	37	13	45768148	45768148	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:45768148C>T	ENST00000405872.1	-	2	958	c.555G>A	c.(553-555)gaG>gaA	p.E185E	GTF2F2_ENST00000340473.6_Intron|KCTD4_ENST00000379108.1_Silent_p.E185E	NM_198404.2	NP_940686.2	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerization domain containing 4	185						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		TTGAAAACTCCTCTGGAAATC	0.363000													51	107					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133748382	133748382	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133748382C>T	ENST00000318560.5	+	6	1424	c.1043C>T	c.(1042-1044)tCg>tTg	p.S348L		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	348	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	ACTCAGATCTCGTCAGCCATG	0.607000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								7	52					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47043884	47043884	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47043884C>T	ENST00000450053.3	+	32	5354	c.5175C>T	c.(5173-5175)ttC>ttT	p.F1725F	NBEAL2_ENST00000383740.2_Silent_p.F4F|NBEAL2_ENST00000292309.5_Silent_p.F1541F	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1725							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TGTCCCAGTTCGAAATGGACA	0.582000													23	60					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197184344	197184344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:197184344C>T	ENST00000260983.2	-	9	1452	c.1270G>A	c.(1270-1272)Gaa>Aaa	p.E424K	HECW2_ENST00000409111.1_Missense_Mutation_p.E68K	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	424					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						CCATTGTGTTCGATAGCATCT	0.512000													22	45					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156957	22156957	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22156957G>A	ENST00000397126.4	-	4	1027	c.879C>T	c.(877-879)gcC>gcT	p.A293A	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCTTACTAAAGGCTTTGCCAC	0.393000													24	64					0	0	1	0	0
MIR654	724024	broad.mit.edu	37	14	101506599	101506599	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:101506599C>T	ENST00000385199.1	+	0	44					NR_030390.1																						GTGCTGAGTTCGTGCCATATG	0.577000													5	12					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204944446	204944446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204944446G>A	ENST00000367172.4	+	15	1934	c.1606G>A	c.(1606-1608)Ggc>Agc	p.G536S	NFASC_ENST00000404076.1_Missense_Mutation_p.G530S|NFASC_ENST00000513543.1_Missense_Mutation_p.G547S|NFASC_ENST00000367171.4_Missense_Mutation_p.G536S|NFASC_ENST00000403080.1_Missense_Mutation_p.G536S|NFASC_ENST00000339876.6_Missense_Mutation_p.G536S|NFASC_ENST00000539706.1_Missense_Mutation_p.G547S|NFASC_ENST00000404907.1_Missense_Mutation_p.G547S|NFASC_ENST00000360049.4_Missense_Mutation_p.G547S|NFASC_ENST00000367170.4_Missense_Mutation_p.G536S|NFASC_ENST00000401399.1_Missense_Mutation_p.G536S|NFASC_ENST00000367169.4_Missense_Mutation_p.G536S|NFASC_ENST00000338586.6_Missense_Mutation_p.G536S|NFASC_ENST00000338515.6_Missense_Mutation_p.G536S			O94856	NFASC_HUMAN	neurofascin	536	Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGCCAGAAGGGGCACCACGGT	0.622000											OREG0014142	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	48	102					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956201	18956201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18956201C>T	ENST00000302797.3	-	1	355	c.131G>A	c.(130-132)gGa>gAa	p.G44E	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	44					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AACTGCGTTTCCTGTCAGCCC	0.567000													67	160					0	0	1	0	0
ZNF454	285676	broad.mit.edu	37	5	178392033	178392033	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178392033C>T	ENST00000320129.3	+	5	931	c.628C>T	c.(628-630)Cat>Tat	p.H210Y	ZNF454_ENST00000519564.1_Missense_Mutation_p.H210Y	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		TCAGAAAATTCATATTAAGGA	0.358000													14	51					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144945144	144945144	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144945144G>A	ENST00000525985.1	-	2	2349	c.2278C>T	c.(2278-2280)Cct>Tct	p.P760S				P58107	EPIPL_HUMAN	epiplakin 1	760						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCGTCAGAAGGGTCCAACAGG	0.642000													40	125					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27528443	27528443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27528443G>A	ENST00000301904.3	+	6	1416	c.1396G>A	c.(1396-1398)Gga>Aga	p.G466R	SCARA3_ENST00000337221.4_Intron	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	466	Collagen-like 1.				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		AGGACCAAGAGGATTCAAAGG	0.662000													31	133					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158589991	158589991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158589991C>T	ENST00000368148.3	-	44	6566	c.6386G>A	c.(6385-6387)aGg>aAg	p.R2129K	SPTA1_ENST00000368147.3_Missense_Mutation_p.R2126K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2129					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTTCCAGGTCCTTTCCAGCAC	0.448000													20	103					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286690	152286690	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152286690A>G	ENST00000368799.1	-	3	707	c.672T>C	c.(670-672)acT>acC	p.T224T	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	224					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCATTTTTGAGTCATTCTTC	0.348000									Ichthyosis				26	92					0	0	1	0	0
HS3ST6	64711	broad.mit.edu	37	16	1962130	1962130	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1962130G>A	ENST00000454677.2	-	2	606	c.541C>T	c.(541-543)Ccc>Tcc	p.P181S	HS3ST6_ENST00000293937.3_Missense_Mutation_p.P164S|HS3ST6_ENST00000443547.1_Missense_Mutation_p.P133S			C9JH64	C9JH64_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	133										endometrium(2)|lung(2)	4						ATGCGGCGGGGGGCCTCTCGC	0.662000													9	9					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48713043	48713043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:48713043G>A	ENST00000236495.5	+	15	1999	c.1949G>A	c.(1948-1950)tGg>tAg	p.W650*	SLC5A9_ENST00000533824.1_Nonsense_Mutation_p.W646*|SLC5A9_ENST00000438567.2_Nonsense_Mutation_p.W625*|SLC5A9_ENST00000471020.1_3'UTR	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	625						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						CTCTGGAGCTGGTTCTGTGGG	0.577000													14	29					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53040680	53040680	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53040680G>A	ENST00000309680.3	-	7	1334	c.1313C>T	c.(1312-1314)gCc>gTc	p.A438V		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	438	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CTTGTTCCTGGCATCCTTGAG	0.567000													45	96					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38886150	38886150	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38886150G>A	ENST00000274276.3	+	7	1251	c.849G>A	c.(847-849)ggG>ggA	p.G283G	OSMR_ENST00000502536.1_Silent_p.G283G	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	283					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					GATTTTCTGGGGAAAAGAAAC	0.333000													22	43					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467317	74467317	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74467317G>A	ENST00000249842.3	+	2	475	c.118G>A	c.(118-120)Gac>Aac	p.D40N	RP11-665J16.1_ENST00000561647.1_RNA|ISLR_ENST00000395118.1_Missense_Mutation_p.D40N	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	40	LRRNT.				cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						TGCCTACCGCGACCTAGAATC	0.652000													29	102					0	0	1	0	0
CYBB	1536	broad.mit.edu	37	X	37663303	37663303	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:37663303C>T	ENST00000378588.4	+	9	1138	c.1071C>T	c.(1069-1071)atC>atT	p.I357I	CYBB_ENST00000545017.1_Silent_p.I325I|CYBB_ENST00000492288.1_3'UTR|CYBB_ENST00000536160.1_Silent_p.I90I|TM4SF2_ENST00000465127.1_Intron	NM_000397.3	NP_000388.2	P04839	CY24B_HUMAN	cytochrome b-245, beta polypeptide	357	FAD-binding FR-type.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|prostate(2)|skin(2)	32						ATATCCGCATCGTTGGGGACT	0.468000													12	56					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	432479	432479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:432479G>A	ENST00000256509.2	+	21	3208	c.2566G>A	c.(2566-2568)Gga>Aga	p.G856R	CHL1_ENST00000397491.2_Missense_Mutation_p.G840R	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	840	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAGAGTACATGGACGTCTGAA	0.383000													9	70					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44433089	44433089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44433089G>A	ENST00000372343.3	+	19	3378	c.2716G>A	c.(2716-2718)Gag>Aag	p.E906K	IPO13_ENST00000372339.3_Missense_Mutation_p.E124K	NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	906					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GTGGATCAAGGAGGCCCTGCA	0.617000													36	70					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11059584	11059584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11059584C>T	ENST00000287766.4	+	4	715	c.294C>T	c.(292-294)ttC>ttT	p.F98F	SLC6A1_ENST00000536032.1_Intron|SLC6A1-AS1_ENST00000414969.2_RNA	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	98					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TCCCACTCTTCCTGCTGGAGT	0.567000													43	106					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858321	9858321	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9858321G>A	ENST00000396573.2	-	14	3389	c.3080C>T	c.(3079-3081)tCc>tTc	p.S1027F	GRIN2A_ENST00000404927.2_Missense_Mutation_p.S1027F|GRIN2A_ENST00000562109.1_Missense_Mutation_p.S1027F|GRIN2A_ENST00000330684.3_Missense_Mutation_p.S1027F|GRIN2A_ENST00000396575.2_Missense_Mutation_p.S1027F|GRIN2A_ENST00000535259.1_Missense_Mutation_p.S870F	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1027					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGATTCTGGGATAGTGAATC	0.542000													18	123					0	0	1	0	0
PLIN1	5346	broad.mit.edu	37	15	90214766	90214766	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90214766C>T	ENST00000300055.5	-	4	445	c.280G>A	c.(280-282)Ggc>Agc	p.G94S	PLIN1_ENST00000430628.2_Missense_Mutation_p.G94S	NM_002666.4	NP_002657.3	O60240	PLIN1_HUMAN	perilipin 1	94					triglyceride catabolic process	lipid particle	lipid binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(2)	13						TGGTCCAAGCCTCGGCAGGCC	0.612000													7	2					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106970943	106970943	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106970943C>T	ENST00000369701.3	+	17	2537	c.2310C>T	c.(2308-2310)ttC>ttT	p.F770F	SORCS3_ENST00000369699.4_Silent_p.F56F	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	770						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCCCAGCTTTCTGGTACAATC	0.448000													23	47					0	0	1	0	0
TREM2	54209	broad.mit.edu	37	6	41126689	41126689	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:41126689C>T	ENST00000373122.4	-	4	658	c.638G>A	c.(637-639)tGg>tAg	p.W213*	TREM2_ENST00000373113.3_Missense_Mutation_p.G200R|TREM2_ENST00000338469.3_Intron			Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	0					axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	11	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGCTTCTGTCCATGCCAGGCT	0.582000													21	56					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65789011	65789011	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65789011C>T	ENST00000312106.5	-	4	1784	c.1647G>A	c.(1645-1647)aaG>aaA	p.K549K		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	549					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CCCGCAGGCTCTTGAAGACCT	0.612000													7	28					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55216155	55216155	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:55216155G>A	ENST00000340465.2	+	5	561	c.475G>A	c.(475-477)Gga>Aga	p.G159R		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	159						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTCAGCAAATGGAAATCCGTG	0.458000													74	212					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49691586	49691586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49691586G>A	ENST00000296452.4	+	5	4711	c.4597G>A	c.(4597-4599)Ggt>Agt	p.G1533S		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1533					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGTAGCCCAGGGTACACAAAC	0.612000													39	92					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278912	36278912	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36278912C>T	ENST00000007510.4	+	21	3589	c.3445C>T	c.(3445-3447)Cac>Tac	p.H1149Y	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.H985Y|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.H988Y			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1149					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						TCCCCCTGACCACCTTGGCTA	0.667000													6	71					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54919601	54919601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54919601C>T	ENST00000474759.1	+	23	2092	c.2044C>T	c.(2044-2046)Cct>Tct	p.P682S	CACNA2D3_ENST00000415676.2_Missense_Mutation_p.P682S|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.P682S|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.P588S|CACNA2D3-AS1_ENST00000471265.1_RNA	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	682						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AGGCAAAGAACCTCTGCTCCA	0.468000													6	9					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44118029	44118029	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:44118029C>T	ENST00000259746.9	+	17	1772	c.1589C>T	c.(1588-1590)cCc>cTc	p.P530L	TMEM63B_ENST00000323267.6_Missense_Mutation_p.P530L			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	530						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTGCTCCTACCCTCGCTGGGA	0.592000													32	68					0	0	1	0	0
GTPBP4	23560	broad.mit.edu	37	10	1038576	1038576	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:1038576C>T	ENST00000360803.4	+	2	278	c.196C>T	c.(196-198)Cta>Tta	p.L66L	GTPBP4_ENST00000545048.1_Silent_p.L19L|GTPBP4_ENST00000538293.1_5'UTR|GTPBP4_ENST00000491635.1_3'UTR	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	66					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TTCACAAATTCTAACAGATTT	0.348000													11	29					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519328	113519328	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113519328C>T	ENST00000284601.3	-	4	1887	c.1819G>A	c.(1819-1821)Ggc>Agc	p.G607S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	607					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AAAGCGCTGCCTTCACTAGTC	0.423000													56	165					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34123547	34123547	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34123547G>A	ENST00000373381.4	-	27	4622	c.4447_splice	c.e27+1	p.I1482_splice	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Splice_Site_p.I355_splice	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1442	CUB 9.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCTTTGTACCGATGCATGTTG	0.587000													27	83					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135766	156135766	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156135766G>A	ENST00000329476.3	+	2	1164	c.675G>A	c.(673-675)ttG>ttA	p.L225L	NPY2R_ENST00000506608.1_Silent_p.L225L	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	225					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CTTCCTTGTTGATCTTGTATG	0.443000													29	114					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112705119	112705119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112705119G>A	ENST00000448454.2	+	8	656	c.656G>A	c.(655-657)gGa>gAa	p.G219E	PALM2_ENST00000374531.2_Missense_Mutation_p.G185E|PALM2-AKAP2_ENST00000374530.3_Intron|AKAP2_ENST00000510514.5_Intron|AKAP2_ENST00000555236.1_Intron|PALM2_ENST00000314527.4_Missense_Mutation_p.G217E|PALM2-AKAP2_ENST00000302798.7_Intron|PALM2_ENST00000483909.1_Missense_Mutation_p.G183E					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						GTGCGCTCAGGAGGCACCGTA	0.468000													4	44					0	0	1	0	0
NIPAL1	152519	broad.mit.edu	37	4	48036926	48036926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:48036926G>A	ENST00000295461.5	+	5	556	c.490G>A	c.(490-492)Gag>Aag	p.E164K	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	164						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						CTTTTTAAACGAGCACTTGAA	0.378000													36	68					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730546	96730546	+	Missense_Mutation	SNP	G	G	A	rs145002930		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96730546G>A	ENST00000216629.6	+	3	1133	c.527G>A	c.(526-528)cGa>cAa	p.R176Q	BDKRB1_ENST00000553356.1_Missense_Mutation_p.R176Q|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	176					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TTCCTGCTGCGATCCATCCAA	0.612000													36	84					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12247800	12247800	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12247800C>T	ENST00000256194.4	+	14	2059	c.1771C>T	c.(1771-1773)Cct>Tct	p.P591S	MICAL2_ENST00000527546.1_Missense_Mutation_p.P591S|MICAL2_ENST00000342902.5_Missense_Mutation_p.P591S|MICAL2_ENST00000537344.1_Missense_Mutation_p.P591S|MICAL2_ENST00000379612.3_Missense_Mutation_p.P591S	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	591	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		GTTTGGGATCCCTCCAGTGAC	0.512000													40	93					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106163486	106163486	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106163486G>A	ENST00000369704.3	+	14	2173		c.e14-1			NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147											NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GTCTTATTCAGACAGGAGTTT	0.403000													4	23					0	0	1	0	0
TTC36	143941	broad.mit.edu	37	11	118399470	118399470	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118399470C>T	ENST00000539546.1	+	3	429	c.94C>T	c.(94-96)Cgt>Tgt	p.R32C	RP11-770J1.3_ENST00000532597.1_RNA|TTC36_ENST00000302783.4_Missense_Mutation_p.R91C|RP11-770J1.3_ENST00000556583.1_RNA|RP11-770J1.3_ENST00000554407.1_RNA|RP11-770J1.3_ENST00000525992.2_RNA|RP11-770J1.3_ENST00000528578.1_RNA			A6NLP5	TTC36_HUMAN	tetratricopeptide repeat domain 36	91							binding			lung(2)	2						CTACAACAACCGTGCCCAGGC	0.637000													22	31					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10250079	10250079	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10250079G>A	ENST00000418404.3	-	12	1344	c.1181C>T	c.(1180-1182)tCt>tTt	p.S394F	MYH13_ENST00000570743.1_Missense_Mutation_p.S394F|MYH13_ENST00000252172.4_Missense_Mutation_p.S394F			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	394	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CATTTCTGCAGAATTCAGTCC	0.473000													16	21					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158911994	158911994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158911994C>T	ENST00000368140.1	+	5	1052	c.807C>T	c.(805-807)atC>atT	p.I269I	PYHIN1_ENST00000368138.3_Silent_p.I260I|PYHIN1_ENST00000485134.1_3'UTR|PYHIN1_ENST00000392254.2_Silent_p.I269I|PYHIN1_ENST00000392252.3_Silent_p.I260I	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	269	HIN-200.				cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					AGAGAATCATCATTATATCAA	0.378000													15	52					0	0	1	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15580433	15580433	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15580433G>A	ENST00000292609.4	-	4	1780	c.1651C>T	c.(1651-1653)Cgc>Tgc	p.R551C	PGLYRP2_ENST00000340880.4_Intron			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	0					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						TGCAGGCTGCGAAGACTCACC	0.716000													13	2					0	0	1	0	0
ABCG4	64137	broad.mit.edu	37	11	119025267	119025267	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:119025267G>A	ENST00000307417.3	+	5	886	c.522G>A	c.(520-522)caG>caA	p.Q174Q	ABCG4_ENST00000449422.2_Silent_p.Q174Q|ABCG4_ENST00000531739.1_Silent_p.Q174Q	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	174	ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GTGAGAAGCAGGAGGTGAAGA	0.582000													9	26					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40337484	40337484	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:40337484G>A	ENST00000310169.2	+	0	139					NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)						elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	TCAGGAAAAAGATGAACTGGT	0.498000													14	41					0	0	1	0	0
MAGEH1	28986	broad.mit.edu	37	X	55479462	55479462	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:55479462C>T	ENST00000342972.1	+	1	925	c.655C>T	c.(655-657)Cct>Tct	p.P219S		NM_014061.3	NP_054780.2	Q9H213	MAGH1_HUMAN	melanoma antigen family H, 1	219					apoptosis			p.P219S(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|skin(2)	15						TTATTCCGCCCCTTAAGTAGA	0.493000													24	17					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114289975	114289975	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114289975C>T	ENST00000309235.5	+	2	458	c.300C>T	c.(298-300)ttC>ttT	p.F100F	ZNF483_ENST00000358151.4_Silent_p.F100F|ZNF483_ENST00000374374.3_Silent_p.F100F|ZNF483_ENST00000355824.3_Silent_p.F100F	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	100	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						TTGAGCAGTTCCTGACCATTT	0.473000													33	75					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142446126	142446126	+	RNA	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142446126C>A	ENST00000606664.1	+	0	1482				MROH5_ENST00000430863.1_RNA																							GCCACCAGGTCCCCGAACAGT	0.677000													7	35					0.000157383	0.000157616	1	1	0
ANKRD20A4	728747	broad.mit.edu	37	9	69420413	69420413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:69420413G>A	ENST00000357336.3	+	13	1584	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K		NM_001098805.1	NP_001092275.1	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	435										breast(1)|large_intestine(1)|liver(1)|lung(9)|pancreas(2)|skin(2)	16						GAAGCTGAAGGAAGAGCATGA	0.358000													11	192					0	0	1	0	0
LEKR1	389170	broad.mit.edu	37	3	156711062	156711062	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:156711062G>A	ENST00000470811.1	+	10	1528	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	LEKR1_ENST00000356539.4_Missense_Mutation_p.E369K			D3DNK7	D3DNK7_HUMAN	leucine, glutamate and lysine rich 1	74										breast(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	11			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			ACTGAAAAATGAAAGGTGCAG	0.294000													19	68					0	0	1	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95174054	95174054	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:95174054C>T	ENST00000354268.4	+	9	1250	c.1177C>T	c.(1177-1179)Ctt>Ttt	p.L393F	SMARCAD1_ENST00000457823.2_Missense_Mutation_p.L393F			Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	393					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TCTTCACTTCCTTCAAGATGC	0.408000													16	114					0	0	1	0	0
VNN2	8875	broad.mit.edu	37	6	133078886	133078886	+	Missense_Mutation	SNP	G	G	A	rs139348170	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:133078886G>A	ENST00000326499.6	-	1	261	c.137C>T	c.(136-138)tCt>tTt	p.S46F	VNN2_ENST00000525270.1_5'UTR|VNN2_ENST00000526192.1_5'UTR|VNN2_ENST00000525289.1_Missense_Mutation_p.S46F	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	46	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		ATCCTCCTGAGAAACTGGTGT	0.418000													35	74					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82785568	82785568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82785568G>A	ENST00000423517.2	-	2	726	c.389C>T	c.(388-390)cCt>cTt	p.P130L	PCLO_ENST00000333891.8_Missense_Mutation_p.P130L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	130					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AATAGTGGAAGGACTCCTCCC	0.478000													27	82					0	0	1	0	0
PLXDC1	57125	broad.mit.edu	37	17	37224179	37224179	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37224179G>A	ENST00000315392.4	-	14	1628	c.1417C>T	c.(1417-1419)Cgc>Tgc	p.R473C	CTD-2206N4.4_ENST00000583447.1_RNA|PLXDC1_ENST00000444911.2_Missense_Mutation_p.R433C|PLXDC1_ENST00000493200.1_5'UTR|PLXDC1_ENST00000539608.1_3'UTR	NM_020405.4	NP_065138.2	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1	473					angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						GGGTGGCTGCGAAACTTCATG	0.617000													21	40					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688082	55688082	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55688082C>T	ENST00000358433.2	-	1	934	c.935G>A	c.(934-936)aGa>aAa	p.R312K		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TTAAAATGGTCTTTTAGAAAA	0.388000													15	24					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168199802	168199802	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168199802C>T	ENST00000519560.1	-	14	1862	c.1443G>A	c.(1441-1443)aaG>aaA	p.K481K	SLIT3_ENST00000332966.8_Silent_p.K481K|SLIT3_ENST00000404867.3_Silent_p.K481K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	481	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCGGAACTTCTTGCTCTTGA	0.607000													15	46					0	0	1	0	0
LACRT	90070	broad.mit.edu	37	12	55025539	55025539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55025539C>T	ENST00000257867.4	-	4	391	c.338G>A	c.(337-339)gGa>gAa	p.G113E	LACRT_ENST00000547511.1_Missense_Mutation_p.G102E	NM_033277.1	NP_150593.1	Q9GZZ8	LACRT_HUMAN	lacritin	113					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(1)	10						GAATTGTTTTCCACCTGGCAC	0.473000													57	147					0	0	1	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153314127	153314127	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153314127G>A	ENST00000368739.3	-	6	947	c.589C>T	c.(589-591)Cgg>Tgg	p.R197W	PGLYRP4_ENST00000359650.5_Missense_Mutation_p.R201W			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	201					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTTCTGCCGAGGGGCCAGG	0.542000													39	114					0	0	1	0	0
GPR151	134391	broad.mit.edu	37	5	145894431	145894431	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145894431C>T	ENST00000311104.2	-	1	1322	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K		NM_194251.2	NP_919227.2	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	416						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(2)	14			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTAACACCTTCCCCTGTCTCT	0.403000													6	16					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10933857	10933857	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10933857C>T	ENST00000298232.7	-	16	1335	c.968G>A	c.(967-969)gGc>gAc	p.G323D	TPTE_ENST00000361285.4_Missense_Mutation_p.G341D|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.G303D	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	341	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTACCTGTGCCTCCTTTACA	0.328000													23	281					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17361191	17361191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17361191C>T	ENST00000252597.3	-	13	2128	c.1955G>A	c.(1954-1956)cGg>cAg	p.R652Q	AC010646.3_ENST00000594059.1_Intron|USHBP1_ENST00000431146.2_Missense_Mutation_p.R588Q	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	652							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						TTCCTGCTTCCGGTGGGCTCC	0.667000													23	46					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10435015	10435015	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10435015C>T	ENST00000245503.5	-	22	3016	c.2632G>A	c.(2632-2634)Gaa>Aaa	p.E878K	MYH2_ENST00000397183.2_Missense_Mutation_p.E878K|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	878					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCTTCCAGTTCCTTCCTTTTT	0.423000													38	41					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173189	126173189	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:126173189G>A	ENST00000339582.2	-	9	3055	c.2247C>T	c.(2245-2247)ctC>ctT	p.L749L	GRM8_ENST00000444921.2_Silent_p.L749L|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Silent_p.L749L			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	749					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GTGAACAAATGAGTGAGAGAT	0.463000										HNSCC(24;0.065)			9	41					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8051146	8051146	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:8051146C>T	ENST00000344293.5	+	5	2627	c.2421C>T	c.(2419-2421)ctC>ctT	p.L807L		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	807	Pro-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						gccccatgctcgtcagccctg	0.806000													5	7					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80374441	80374441	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:80374441G>A	ENST00000265361.3	-	18	2586	c.2025C>T	c.(2023-2025)tcC>tcT	p.S675S	SEMA3C_ENST00000544525.1_Silent_p.S693S|SEMA3C_ENST00000419255.2_Silent_p.S675S	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	675					immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						AGGTCCATGGGGACCATTTGT	0.463000													36	75					0	0	1	0	0
ARHGEF25	115557	broad.mit.edu	37	12	58006880	58006880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:58006880C>T	ENST00000286494.4	+	2	725	c.265C>T	c.(265-267)Ctc>Ttc	p.L89F	AC025165.8_ENST00000444467.1_RNA|AC025165.8_ENST00000356672.3_RNA|ARHGEF25_ENST00000333972.7_Missense_Mutation_p.L128F	NM_182947.3	NP_891992.2	Q86VW2	ARHGP_HUMAN	Rho guanine nucleotide exchange factor (GEF) 25	89					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	28						CAAACATTGTCTCAGTGTGGA	0.592000													4	33					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6733289	6733289	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6733289G>A	ENST00000264080.7	-	9	773	c.747C>T	c.(745-747)ccC>ccT	p.P249P	GPR108_ENST00000430424.4_Silent_p.P7P	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	249						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						GGAAGCCATCGGGGTTCTTCT	0.657000													19	38					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49710967	49710967	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:49710967G>A	ENST00000451037.2	-	8	1774	c.834C>T	c.(832-834)atC>atT	p.I278I	CA10_ENST00000570565.1_Silent_p.I203I|CA10_ENST00000442502.2_Silent_p.I278I|CA10_ENST00000285273.4_Silent_p.I278I|CA10_ENST00000340813.6_Silent_p.I284I	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	278					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGCTCAGAAAGATCTGAGATG	0.512000													21	67					0	0	1	0	0
MGST2	4258	broad.mit.edu	37	4	140616381	140616381	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:140616381C>T	ENST00000265498.1	+	3	441	c.189C>T	c.(187-189)ttC>ttT	p.F63F	MGST2_ENST00000506797.1_Intron|MGST2_ENST00000515137.1_3'UTR	NM_001204366.1|NM_002413.4	NP_001191295.1|NP_002404.1	Q99735	MGST2_HUMAN	microsomal glutathione S-transferase 2	63					glutathione biosynthetic process|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane|plasma membrane	enzyme activator activity|glutathione peroxidase activity|glutathione transferase activity|leukotriene-C4 synthase activity			lung(1)|ovary(1)	2	all_hematologic(180;0.162)				Glutathione(DB00143)	ATCCTATATTCATAATTACAT	0.318000													12	64					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278595	50278595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:50278595G>A	ENST00000442544.2	+	2	879	c.263G>A	c.(262-264)aGg>aAg	p.R88K	DCC_ENST00000412726.1_5'UTR	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	88	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ATGGATGAAAGGAAGCAGCAA	0.483000													20	99					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9047337	9047337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:9047337G>A	ENST00000457346.2	-	21	2840	c.2766C>T	c.(2764-2766)acC>acT	p.T922T	RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000520467.1_Silent_p.T865T|SCUBE2_ENST00000450649.2_Silent_p.T701T|SCUBE2_ENST00000309263.3_Silent_p.T893T			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	893						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		TTGACCTGGAGGTGAAGGCGA	0.512000													48	135					0	0	1	0	0
GKN1	56287	broad.mit.edu	37	2	69204640	69204640	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:69204640G>A	ENST00000377938.2	+	2	131	c.68G>A	c.(67-69)gGa>gAa	p.G23E		NM_019617.3	NP_062563.3	Q9NS71	GKN1_HUMAN	gastrokine 1	23					digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						GTCTTTGCTGGACTTCTTGGA	0.368000													36	112					0	0	1	0	0
LGMN	5641	broad.mit.edu	37	14	93179168	93179168	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93179168G>A	ENST00000393218.2	-	9	929	c.592C>T	c.(592-594)Ctg>Ttg	p.L198L	LGMN_ENST00000334869.4_Silent_p.L198L|LGMN_ENST00000555699.1_Silent_p.L198L|LGMN_ENST00000557434.1_Silent_p.L198L	NM_001008530.2	NP_001008530.1	Q99538	LGMN_HUMAN	legumain	198					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|skin(2)	18		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		TTATCCGGCAGGTGGTTCATC	0.592000													6	30					0	0	1	0	0
MBTPS2	51360	broad.mit.edu	37	X	21863445	21863445	+	Silent	SNP	C	C	T	rs3834687		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:21863445C>T	ENST00000365779.2	+	3	462	c.381C>T	c.(379-381)tcC>tcT	p.S127S	MBTPS2_ENST00000465888.1_3'UTR|MBTPS2_ENST00000379484.5_Silent_p.S127S			O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase, site 2	127	Poly-Ser.				cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			breast(2)|endometrium(3)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24						cttcctcttcctcttcttcat	0.418000													26	16					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186954048	186954048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186954048G>A	ENST00000296280.6	-	11	1836	c.1611C>T	c.(1609-1611)gcC>gcT	p.A537A	MASP1_ENST00000495249.1_5'UTR|MASP1_ENST00000392472.2_Silent_p.A424A|MASP1_ENST00000337774.5_Intron	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	536	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		GCACCACTCGGGCAGCTGAGC	0.572000													10	69					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242129552	242129552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242129552G>A	ENST00000274979.8	+	2	339	c.236G>A	c.(235-237)aGg>aAg	p.R79K	ANO7_ENST00000402530.3_Missense_Mutation_p.R79K|ANO7_ENST00000402430.3_Missense_Mutation_p.R79K	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	79						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						GCAGAGAAGAGGGGCTCTTAC	0.662000													4	5					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997234	82997234	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82997234G>A	ENST00000307792.3	-	17	2463	c.1996C>T	c.(1996-1998)Cgt>Tgt	p.R666C	SEMA3E_ENST00000427262.1_Missense_Mutation_p.R606C	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	666	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				GTGATTTTACGGACCGTATGG	0.463000													39	76					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17892613	17892613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17892613C>T	ENST00000594202.1	+	23	2200	c.1921C>T	c.(1921-1923)Cgt>Tgt	p.R641C	FCHO1_ENST00000600676.1_Missense_Mutation_p.R641C|FCHO1_ENST00000597512.1_Missense_Mutation_p.R648C|FCHO1_ENST00000252771.7_Missense_Mutation_p.R641C|FCHO1_ENST00000595033.1_Missense_Mutation_p.R591C|FCHO1_ENST00000596951.1_Missense_Mutation_p.R641C|FCHO1_ENST00000596536.1_Missense_Mutation_p.R641C|FCHO1_ENST00000539407.1_Missense_Mutation_p.R641C|FCHO1_ENST00000389133.4_Missense_Mutation_p.R641C	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	641										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CGCCTACTTCCGTGGCCACAG	0.637000													36	64					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938959	2938959	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2938959G>A	ENST00000378404.2	+	1	914	c.709G>A	c.(709-711)Gag>Aag	p.E237K		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	237						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GAGGCCGGAGGAGGTCCTGAG	0.652000													18	60					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566348	45566348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:45566348C>T	ENST00000588982.1	-	3	1632	c.1131G>A	c.(1129-1131)ggG>ggA	p.G377G	ZBTB7C_ENST00000586438.1_Silent_p.G377G|ZBTB7C_ENST00000535628.2_Silent_p.G377G|ZBTB7C_ENST00000590800.1_Silent_p.G377G|ZBTB7C_ENST00000332053.2_Silent_p.G377G			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	377						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GCGGCAGCTTCCCGGCCCCCA	0.642000													39	86					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118574371	118574371	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:118574371C>T	ENST00000336338.5	-	25	3618	c.3553G>A	c.(3553-3555)Gaa>Aaa	p.E1185K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1185						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTGGGTTTTTCTTTGCCTTTT	0.383000													29	126					0	0	1	0	0
PHF8	23133	broad.mit.edu	37	X	54048724	54048724	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54048724G>A	ENST00000338154.6	-	4	765	c.261C>T	c.(259-261)ttC>ttT	p.F87F	PHF8_ENST00000338946.6_Silent_p.F87F|PHF8_ENST00000357988.5_Silent_p.F123F|PHF8_ENST00000322659.8_Silent_p.F87F	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	123					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						GCTCTCTGACGAACGTAGGGC	0.537000													59	44					0	0	1	0	0
TNPO2	30000	broad.mit.edu	37	19	12814536	12814536	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12814536G>A	ENST00000425528.1	-	19	2459	c.2102C>T	c.(2101-2103)cCc>cTc	p.P701L	TNPO2_ENST00000441499.1_Missense_Mutation_p.P701L|TNPO2_ENST00000356861.5_Missense_Mutation_p.P701L|TNPO2_ENST00000588216.1_Missense_Mutation_p.P701L|TNPO2_ENST00000450764.2_Missense_Mutation_p.P701L|TNPO2_ENST00000592287.1_Missense_Mutation_p.P701L			O14787	TNPO2_HUMAN	transportin 2	701					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						ACCGATACAGGGCTTGACATG	0.577000													3	9					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61533631	61533631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61533631G>A	ENST00000278836.5	+	3	432	c.336G>A	c.(334-336)aaG>aaA	p.K112K	MYRF_ENST00000265460.5_Silent_p.K103K	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		CTGCCCCCAAGCCCTTCCCGG	0.701000													19	45					0	0	1	0	0
IGFALS	3483	broad.mit.edu	37	16	1841107	1841107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1841107C>T	ENST00000415638.3	-	2	1505	c.1426G>A	c.(1426-1428)Gag>Aag	p.E476K	IGFALS_ENST00000215539.3_Missense_Mutation_p.E438K	NM_001146006.1|NM_004970.2	NP_001139478.1|NP_004961.1	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	438					cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						AGGTCGAGCTCCAGCAGCTCC	0.682000													3	20					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67092929	67092929	+	Missense_Mutation	SNP	G	G	A	rs138992705	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67092929G>A	ENST00000284425.2	-	24	3308	c.3134C>T	c.(3133-3135)tCc>tTc	p.S1045F	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1045					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CCATAGCTGGGACTTAGCATT	0.323000													6	52					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21771626	21771626	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21771626G>A	ENST00000206660.6	+	5	724	c.724G>A	c.(724-726)Gag>Aag	p.E242K	RPGRIP1_ENST00000556336.1_Missense_Mutation_p.E215K|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.E242K|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.E215K			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	242					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CAAGTCTCCTGAGAAAATGTG	0.478000													26	37					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86590635	86590635	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:86590635C>T	ENST00000370571.2	-	3	1750	c.1384G>A	c.(1384-1386)Gaa>Aaa	p.E462K	COL24A1_ENST00000436319.1_Missense_Mutation_p.E462K	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	462					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TAGCTATTTTCGATGGGATAA	0.368000													16	68					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420887	55420887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55420887C>T	ENST00000242994.3	+	2	1042	c.664C>T	c.(664-666)Ctt>Ttt	p.L222F		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	222					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						AACACATCTCCTTCATCTCAA	0.498000													26	70					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48602556	48602556	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48602556G>A	ENST00000328333.8	-	116	8713	c.8606C>T	c.(8605-8607)cCt>cTt	p.P2869L	COL7A1_ENST00000454817.1_Missense_Mutation_p.P2837L	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2869	Nonhelical region (NC2).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACTATCCCAAGGAGCTTCAGG	0.612000													5	32					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854449	12854449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12854449C>T	ENST00000332296.7	+	3	776	c.673C>T	c.(673-675)Cgt>Tgt	p.R225C		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	225										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AAGAAAGCTTCGTTGTTACCT	0.398000													37	770					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236205562	236205562	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:236205562C>T	ENST00000264187.6	-	4	865	c.783G>A	c.(781-783)tgG>tgA	p.W261*	NID1_ENST00000366595.3_Nonsense_Mutation_p.W261*	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	261	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TCTCAAACACCCAGACACCCT	0.552000													70	229					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057713	9057713	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9057713C>T	ENST00000397910.4	-	3	29936	c.29733G>A	c.(29731-29733)atG>atA	p.M9911I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9913	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATTTCTGTCATGGAGACTT	0.468000													12	167					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55444993	55444993	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55444993C>T	ENST00000446217.1	-	10	3072	c.2670G>A	c.(2668-2670)ggG>ggA	p.G890G	NLRP7_ENST00000592784.1_Silent_p.G862G|NLRP7_ENST00000340844.2_Silent_p.G862G|NLRP7_ENST00000588756.1_Silent_p.G862G|NLRP7_ENST00000448121.2_Silent_p.G834G|NLRP7_ENST00000328092.5_Silent_p.G834G|NLRP7_ENST00000590030.1_Silent_p.G862G			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	862							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GAAACTTCACCCCTGTATCCC	0.507000													25	63					0	0	1	0	0
C6orf58	352999	broad.mit.edu	37	6	127898505	127898505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:127898505G>A	ENST00000329722.7	+	1	187	c.175G>A	c.(175-177)Gag>Aag	p.E59K	C6orf58_ENST00000498112.1_Intron	NM_001010905.1	NP_001010905.1	Q6P5S2	CF058_HUMAN	chromosome 6 open reading frame 58	59						extracellular region				kidney(3)|large_intestine(3)|liver(1)|lung(7)|pancreas(1)	15				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		GGTATACCTTGAGAGAATGGG	0.438000													55	63					0	0	1	0	0
PPAP2C	8612	broad.mit.edu	37	19	288132	288132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:288132G>A	ENST00000269812.3	-	2	141	c.92C>T	c.(91-93)cCg>cTg	p.P31L	PPAP2C_ENST00000434325.2_5'UTR|PPAP2C_ENST00000327790.3_Missense_Mutation_p.P52L	NM_003712.2|NM_177526.1	NP_003703.1|NP_803545.1	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C	31					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(1)|lung(1)|skin(1)	5		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGCTTGTACGGGGCGTTCAC	0.627000													36	77					0	0	1	0	0
SULT2B1	6820	broad.mit.edu	37	19	49055564	49055564	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49055564G>A	ENST00000201586.2	+	1	233	c.55G>A	c.(55-57)Gac>Aac	p.D19N		NM_177973.1	NP_814444.1	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	19					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	11		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		CTATGAAGATGACATCTCGGA	0.672000													8	25					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78413252	78413252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78413252G>A	ENST00000278550.7	-	28	4868	c.4406C>T	c.(4405-4407)tCa>tTa	p.S1469L		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AGCGGTGGCTGACTCCAGGGT	0.567000													10	23					0	0	1	0	0
TOX4	9878	broad.mit.edu	37	14	21945658	21945658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21945658C>T	ENST00000405508.1	+	3	286	c.10C>T	c.(10-12)Ccc>Tcc	p.P4S	TOX4_ENST00000262709.3_Missense_Mutation_p.P4S|TOX4_ENST00000494242.1_3'UTR|TOX4_ENST00000448790.2_Intron			O94842	TOX4_HUMAN	TOX high mobility group box family member 4	4						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			large_intestine(8)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		TTTCCAGTTTCCCGGAGGAAA	0.592000											OREG0022569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	131					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219492822	219492822	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219492822C>T	ENST00000450993.2	+	7	1182	c.843C>T	c.(841-843)ttC>ttT	p.F281F	PLCD4_ENST00000432688.1_Silent_p.F281F|PLCD4_ENST00000417849.1_Silent_p.F281F	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	281					intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GAGACATCTTCAACCCAGCCT	0.522000													25	78					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702044	181702044	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:181702044C>T	ENST00000526775.1	+	19	2930	c.2765C>T	c.(2764-2766)tCt>tTt	p.S922F	CACNA1E_ENST00000367567.4_Missense_Mutation_p.S548F|CACNA1E_ENST00000358338.5_Missense_Mutation_p.S873F|CACNA1E_ENST00000367570.1_Missense_Mutation_p.S941F|CACNA1E_ENST00000360108.3_Missense_Mutation_p.S922F|CACNA1E_ENST00000367573.2_Missense_Mutation_p.S941F|CACNA1E_ENST00000357570.5_Missense_Mutation_p.S892F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	941					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CGGAGCAGGTCTGCCAGCCAG	0.632000													38	91					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047037	42047037	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:42047037G>A	ENST00000372584.1	-	3	4446	c.3432C>T	c.(3430-3432)tcC>tcT	p.S1144S	HIVEP3_ENST00000247584.5_Silent_p.S1144S|HIVEP3_ENST00000372583.1_Silent_p.S1144S|HIVEP3_ENST00000429157.2_Silent_p.S1144S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1144					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGAGAAAAGGGAGACTGGTG	0.587000													51	111					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328824	57328824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57328824C>T	ENST00000326441.9	-	10	1349	c.986G>A	c.(985-987)gGa>gAa	p.G329E	PEG3_ENST00000423103.2_Missense_Mutation_p.G329E|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.G203E|PEG3_ENST00000598410.1_Missense_Mutation_p.G205E|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	329					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCTTGCTCTTCCCGATTTGGA	0.468000													15	68					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58077194	58077194	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58077194C>T	ENST00000219271.3	+	8	2169	c.1384C>T	c.(1384-1386)Ccc>Tcc	p.P462S		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	462	Hemopexin-like 2.				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						CCTGGGCATCCCCTATGACCG	0.632000													3	9					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29608128	29608128	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29608128G>A	ENST00000431530.3	+	2	2400	c.2342G>A	c.(2341-2343)gGa>gAa	p.G781E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	771	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CCCCAGCTAGGATTGGGTGCA	0.507000													18	50					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187201178	187201178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187201178C>T	ENST00000264692.4	+	8	945	c.612C>T	c.(610-612)ctC>ctT	p.L204L	F11_ENST00000403665.2_Silent_p.L256L			P03951	FA11_HUMAN	coagulation factor XI	256	Apple 3.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	ATCTTTGTCTCCTTAAAACAT	0.373000													29	75					0	0	1	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101776545	101776545	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:101776545C>T	ENST00000334289.3	-	4	870	c.275G>A	c.(274-276)aGa>aAa	p.R92K		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	92					signal transduction	extracellular space	receptor binding	p.R92I(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		TTTGGTACTTCTTGTGTAGGA	0.274000													13	46					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201355640	201355640	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201355640C>T	ENST00000391967.2	-	3	1150	c.849G>A	c.(847-849)agG>agA	p.R283R	LAD1_ENST00000367313.3_Silent_p.R297R	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	283						basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						AGGCTGTGGCCCTCTTTGGGG	0.632000													31	110					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91795141	91795141	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91795141C>T	ENST00000394232.1	+	3	1014	c.544C>T	c.(544-546)Ctg>Ttg	p.L182L	SV2B_ENST00000330276.4_Silent_p.L182L|SV2B_ENST00000545111.2_Silent_p.L31L|SV2B_ENST00000557291.1_3'UTR	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	182					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CAGCATGTCTCTGGCCGTCAA	0.562000													11	155					0	0	1	0	0
SETMAR	6419	broad.mit.edu	37	3	4354988	4354988	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:4354988C>T	ENST00000358065.4	+	2	630	c.563C>T	c.(562-564)tCc>tTc	p.S188F	SUMF1_ENST00000534863.1_Intron|SETMAR_ENST00000430981.1_Missense_Mutation_p.S188F|SETMAR_ENST00000425863.1_Intron	NM_006515.3	NP_006506.3	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion gene	175	Histone-lysine N-methyltransferase.|SET.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)	9		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		CAAACAAAATCCGACTCCAAT	0.363000								Chromatin Structure					26	71					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354698	45354698	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:45354698C>T	ENST00000359271.2	+	2	1273	c.1023C>T	c.(1021-1023)ctC>ctT	p.L341L		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	341						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				AGACAGGCCTCCCTGGAGACT	0.597000													20	63					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1655922	1655922	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:1655922C>T	ENST00000324015.3	+	9	978	c.901C>T	c.(901-903)Ctt>Ttt	p.L301F	SERPINF2_ENST00000450523.2_Missense_Mutation_p.L237F|SERPINF2_ENST00000382061.4_Missense_Mutation_p.L301F	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	301					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	CTTTGTGGTCCTTGTACCCAC	0.547000													6	79					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31588337	31588337	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:31588337G>A	ENST00000379416.3	-	23	2578	c.2530C>T	c.(2530-2532)Ctg>Ttg	p.L844L		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	844					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TATCTGGCCAGGAAGGGATGT	0.577000													33	100					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57290806	57290806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57290806G>A	ENST00000391708.3	-	11	1223	c.681C>T	c.(679-681)cgC>cgT	p.R227R	ZIM2_ENST00000593711.1_Silent_p.R227R|ZIM2_ENST00000601070.1_Silent_p.R227R|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000599935.1_Silent_p.R227R|ZIM2_ENST00000221722.5_Silent_p.R227R	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		CCTCTTCCAGGCGTGAGATAA	0.507000													32	97					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30705252	30705252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:30705252C>T	ENST00000256246.2	-	1	1356	c.1282G>A	c.(1282-1284)Gaa>Aaa	p.E428K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	428										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GGTTCATTTTCATTTTTCCTA	0.338000													41	151					0	0	1	0	0
PFKFB3	5209	broad.mit.edu	37	10	6261655	6261655	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:6261655A>G	ENST00000379775.4	+	7	952	c.623_splice	c.e7+1	p.R208_splice	PFKFB3_ENST00000379782.3_Splice_Site_p.R208_splice|PFKFB3_ENST00000379785.1_Splice_Site_p.R208_splice|PFKFB3_ENST00000317350.4_Splice_Site_p.R208_splice|PFKFB3_ENST00000360521.2_Splice_Site_p.R208_splice|PFKFB3_ENST00000379789.4_Splice_Site_p.R188_splice|PFKFB3_ENST00000536985.1_3'UTR|PFKFB3_ENST00000540253.1_Splice_Site_p.R222_splice	NM_004566.3	NP_004557.1	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	208	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|liver(2)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)	22						CAAATGCGACAGGTGATTCCC	0.502000													16	66					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55027323	55027323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:55027323G>A	ENST00000324000.3	+	4	2992	c.958G>A	c.(958-960)Gga>Aga	p.G320R		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	320					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CCACTTGTATGGATTTTGGCC	0.423000													16	51					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983180	97983180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97983180G>A	ENST00000383696.2	+	1	93	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TGAGGAGATGGAAGAGGAAAA	0.388000													73	153					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39039051	39039051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39039051C>T	ENST00000355481.4	+	88	12389	c.12258C>T	c.(12256-12258)gaC>gaT	p.D4086D	RYR1_ENST00000360985.3_Silent_p.D4086D|RYR1_ENST00000359596.3_Silent_p.D4091D	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4091					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCAAGAAGGACTTCCAGAAGG	0.572000													40	69					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158225851	158225851	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158225851G>A	ENST00000289429.5	+	3	916	c.383G>A	c.(382-384)gGa>gAa	p.G128E		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	128					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	AAGGTCTCAGGAAGCTTCTTG	0.438000													31	106					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48736816	48736816	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48736816C>T	ENST00000316623.5	-	49	6414	c.5959G>A	c.(5959-5961)Ggt>Agt	p.G1987S		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1987	EGF-like 34; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGACAGGTACCTGGTGCACAT	0.423000													33	125					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7695297	7695297	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7695297G>A	ENST00000572933.1	+	45	8423	c.6963G>A	c.(6961-6963)atG>atA	p.M2321I	DNAH2_ENST00000389173.2_Missense_Mutation_p.M2321I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2321					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGTTCAGCATGATCTGGTCTG	0.532000													55	78					0	0	1	0	0
IFNA14	3448	broad.mit.edu	37	9	21239414	21239414	+	Missense_Mutation	SNP	G	G	A	rs146172550	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21239414G>A	ENST00000380222.2	-	1	564	c.521C>T	c.(520-522)tCc>tTc	p.S174F		NM_002172.2	NP_002163.2	P01570	IFN14_HUMAN	interferon, alpha 14	174					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)	11				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AAAAGAGAGGGATCTCATGAT	0.388000													101	355					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52602104	52602104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52602104C>T	ENST00000591504.1	-	7	821	c.547G>A	c.(547-549)Gaa>Aaa	p.E183K	CCDC68_ENST00000432185.1_Missense_Mutation_p.E183K|CCDC68_ENST00000337363.4_Missense_Mutation_p.E183K	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	183										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		CTGTGTTTTTCTTCAAGTTTT	0.358000													25	46					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370850	240370850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240370850C>T	ENST00000319653.9	+	5	2968	c.2738C>T	c.(2737-2739)cCt>cTt	p.P913L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	913	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCCCTCCCCCTCCTCTTCCC	0.662000													42	85					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576177	33576177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33576177G>A	ENST00000504830.1	-	19	4289	c.3954C>T	c.(3952-3954)atC>atT	p.I1318I	ADAMTS12_ENST00000352040.3_Silent_p.I1233I	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1318	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						AGTTTCCGACGATCCAGTGTG	0.453000										HNSCC(64;0.19)			40	90					0	0	1	0	0
FAM19A4	151647	broad.mit.edu	37	3	68929890	68929890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:68929890C>T	ENST00000295569.7	-	3	613	c.121G>A	c.(121-123)Gga>Aga	p.G41R		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	41						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		CCTGCATGTCCCCGGAGGTGC	0.478000													18	55					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143747663	143747663	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143747663C>T	ENST00000408906.2	+	1	203	c.169C>T	c.(169-171)Ccc>Tcc	p.P57S		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					ACTGCACACCCCCATGTACTT	0.507000													42	94					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152803	18152803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18152803C>T	ENST00000375406.1	+	3	1106	c.890C>T	c.(889-891)gCc>gTc	p.A297V		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	297						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CACGTGATGGCCTGCGGGGGC	0.652000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	66					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175896986	175896986	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:175896986G>A	ENST00000359240.3	+	5	980	c.310G>A	c.(310-312)Ggt>Agt	p.G104S	ADAM29_ENST00000404450.4_Missense_Mutation_p.G104S|ADAM29_ENST00000445694.1_Missense_Mutation_p.G104S|ADAM29_ENST00000514159.1_Missense_Mutation_p.G104S	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	104					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CTACTATCATGGTTATGTGGA	0.438000													21	51					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35752159	35752159	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35752159C>T	ENST00000400441.3	-	15	1828	c.1829G>A	c.(1828-1830)cGa>cAa	p.R610Q	MROH8_ENST00000441008.2_Missense_Mutation_p.R596Q|MROH8_ENST00000217333.8_Missense_Mutation_p.R439Q					maestro heat-like repeat family member 8																		CGTAGCTGCTCGAAGCCTGTT	0.483000													6	33					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89251712	89251712	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89251712C>T	ENST00000289746.2	+	5	699	c.634C>T	c.(634-636)Cgc>Tgc	p.R212C		NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	212	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		AGGAGAGATCCGCACAGTGCA	0.697000													6	3					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103569	53103569	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:53103569G>A	ENST00000408890.4	+	1	221	c.205G>A	c.(205-207)Ggg>Agg	p.G69R		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	69										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CTTCCAGTGGGGGCGCCCGGT	0.706000													6	64					0	0	1	0	0
B3GNT5	84002	broad.mit.edu	37	3	182988250	182988250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:182988250C>T	ENST00000326505.3	+	2	1194	c.664C>T	c.(664-666)Cgt>Tgt	p.R222C	MCF2L2_ENST00000447025.2_Intron|MCF2L2_ENST00000473233.1_Intron|B3GNT5_ENST00000460419.1_Missense_Mutation_p.R222C|B3GNT5_ENST00000465010.1_Missense_Mutation_p.R222C|MCF2L2_ENST00000328913.3_Intron	NM_032047.4	NP_114436.1	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	222					central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TTGGATTGGTCGTGTTCATCG	0.423000													64	165					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113286201	113286201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113286201C>T	ENST00000362072.3	-	5	1009	c.665G>A	c.(664-666)cGa>cAa	p.R222Q	DRD2_ENST00000544518.1_Missense_Mutation_p.R221Q|DRD2_ENST00000542968.1_Missense_Mutation_p.R222Q|DRD2_ENST00000346454.3_Missense_Mutation_p.R222Q|DRD2_ENST00000538967.1_Missense_Mutation_p.R222Q|DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000355319.2_Missense_Mutation_p.R222Q	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	222	Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGTGTTGACTCGCTTGCGGCG	0.567000													44	138					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586117	20586117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20586117C>T	ENST00000315543.4	+	1	552	c.552C>T	c.(550-552)ctC>ctT	p.L184L		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TCTTGGGTCTCCTTCACTCAG	0.448000													39	79					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37689061	37689061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:37689061C>T	ENST00000315215.7	+	8	1416	c.1053C>T	c.(1051-1053)tcC>tcT	p.S351S	GPR124_ENST00000412232.2_Silent_p.S351S			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	351					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			CCTCTGCCTCCTACTGCCCCG	0.662000													12	31					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36651812	36651812	+	Missense_Mutation	SNP	C	C	T	rs140963190		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:36651812C>T	ENST00000543751.1	+	11	1040	c.895C>T	c.(895-897)Cgt>Tgt	p.R299C	MELK_ENST00000541717.1_Missense_Mutation_p.R331C|MELK_ENST00000298048.2_Missense_Mutation_p.R331C|MELK_ENST00000545008.1_Missense_Mutation_p.R260C|MELK_ENST00000536987.1_Missense_Mutation_p.R200C|MELK_ENST00000536860.1_Missense_Mutation_p.R283C|MELK_ENST00000538311.1_Missense_Mutation_p.R137C|MELK_ENST00000536329.1_Missense_Mutation_p.R260C	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	331						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			AAAACCAGTTCGTTTAAGGCT	0.468000													109	224					0	0	1	0	0
PPAP2C	8612	broad.mit.edu	37	19	282190	282190	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:282190G>A	ENST00000269812.3	-	5	710	c.661C>T	c.(661-663)Cac>Tac	p.H221Y	PPAP2C_ENST00000434325.2_Missense_Mutation_p.H165Y|PPAP2C_ENST00000327790.3_Missense_Mutation_p.H242Y	NM_003712.2|NM_177526.1	NP_003703.1|NP_803545.1	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C	221					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(1)|lung(1)|skin(1)	5		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGCTCCAGTGGTGTTTGTAA	0.587000													18	33					0	0	1	0	0
IGHV3-7	28452	broad.mit.edu	37	14	106518487	106518487	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106518487G>A	ENST00000390598.2	-	0	342																											CTCTGGAGATGGTGAATCGGC	0.542000													126	281					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94028396	94028396	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94028396G>A	ENST00000297268.6	+	4	603	c.132_splice	c.e4+1	p.R44_splice		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	44					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GTGGAGAAAGGGTGTGTAATT	0.373000										HNSCC(75;0.22)			40	100					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196398761	196398761	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:196398761G>A	ENST00000367433.5	-	9	866	c.765C>T	c.(763-765)tcC>tcT	p.S255S	KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000367431.4_Silent_p.S255S|KCNT2_ENST00000294725.8_Silent_p.S255S			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	255						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CAAAAAGCTTGGAGGACCATG	0.403000													27	67					0	0	1	0	0
KLHL31	401265	broad.mit.edu	37	6	53519041	53519041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:53519041C>T	ENST00000370905.3	-	2	1170	c.1030G>A	c.(1030-1032)Gga>Aga	p.G344R	KLHL31_ENST00000407079.1_Missense_Mutation_p.G344R	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					TTGCTCCATCCATTTTCAGGG	0.498000													28	79					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417779	150417779	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150417779G>A	ENST00000307194.5	+	3	827	c.687G>A	c.(685-687)caG>caA	p.Q229Q		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCTGGCGCAGGTGCTGCGCT	0.706000													5	11					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19576956	19576956	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:19576956C>T	ENST00000341998.2	-	5	1255	c.1194G>A	c.(1192-1194)gaG>gaA	p.E398E	SLC24A2_ENST00000286344.3_Silent_p.E381E	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	398					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GCCTCTCGTTCTCATCCACAT	0.522000													50	77					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148930248	148930248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:148930248C>T	ENST00000264613.6	-	2	646	c.384G>A	c.(382-384)aaG>aaA	p.K128K		NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	128	F5/8 type A 1.|Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	CCTCATGTTCCTTATAGTAAG	0.373000													9	73					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169589453	169589453	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169589453C>T	ENST00000261509.6	+	3	1232	c.1021C>T	c.(1021-1023)Cgc>Tgc	p.R341C	PALLD_ENST00000512127.1_5'UTR|PALLD_ENST00000333488.4_Missense_Mutation_p.R218C|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Missense_Mutation_p.R341C	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	341	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CGACACAGGTCGCTACACCTG	0.522000									Pancreatic Cancer, Familial Clustering of				11	92					0	0	1	0	0
ZNF584	201514	broad.mit.edu	37	19	58928497	58928497	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58928497C>T	ENST00000306910.4	+	4	1135	c.612C>T	c.(610-612)ccC>ccT	p.P204P	ZNF584_ENST00000593920.1_Silent_p.P159P|ZNF584_ENST00000599238.1_3'UTR	NM_173548.1	NP_775819.1	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		ATATTAACCCCCGAAAAATTC	0.478000													12	42					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7806009	7806009	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:7806009C>T	ENST00000303635.7	+	18	4682	c.4475C>T	c.(4474-4476)gCc>gTc	p.A1492V	CAMTA1_ENST00000439411.2_Missense_Mutation_p.A1478V|CAMTA1_ENST00000476864.1_Missense_Mutation_p.A56V	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CTTCCCTCCGCCGCGGATTGG	0.488000			T	WWTR1	epitheliod hemangioendothelioma								27	124					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80874910	80874910	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:80874910C>T	ENST00000466387.1	+	22	3355	c.2631C>T	c.(2629-2631)ttC>ttT	p.F877F	CTNNA2_ENST00000540488.1_Silent_p.F832F|CTNNA2_ENST00000496558.1_Silent_p.F877F|CTNNA2_ENST00000402739.4_Silent_p.F925F|CTNNA2_ENST00000343114.3_Silent_p.F556F|CTNNA2_ENST00000361291.4_Silent_p.F911F|CTNNA2_ENST00000541047.1_Silent_p.F877F			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	925					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CTGAAGAATTCCAGACACGAG	0.458000													49	189					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179638652	179638652	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179638652C>T	ENST00000589042.1	-	31	7467	c.7243G>A	c.(7243-7245)Gaa>Aaa	p.E2415K	TTN_ENST00000342992.6_Missense_Mutation_p.E2415K|TTN_ENST00000360870.5_Missense_Mutation_p.E2415K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E2369K|TTN_ENST00000342175.6_Missense_Mutation_p.E2369K|TTN_ENST00000359218.5_Missense_Mutation_p.E2369K|TTN_ENST00000591111.1_Missense_Mutation_p.E2415K|TTN-AS1_ENST00000584485.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2139	Ig-like 13.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E2415Q(3)|p.E2369Q(3)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCATGTCTTCAATGAGCAGC	0.478000													34	109					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4947742	4947742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:4947742C>T	ENST00000345988.2	-	9	995	c.906G>A	c.(904-906)tgG>tgA	p.W302*	PPL_ENST00000590782.2_Nonsense_Mutation_p.W300*	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	302					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						GGTACTCCTTCCAGTCTGCGT	0.607000													19	29					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160786439	160786439	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160786439C>T	ENST00000263285.5	+	5	1158	c.1128C>T	c.(1126-1128)atC>atT	p.I376I	LY9_ENST00000341032.4_Intron|LY9_ENST00000368035.1_Silent_p.I28I|LY9_ENST00000368040.1_Silent_p.I28I|LY9_ENST00000368041.2_Intron	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	376	Ig-like C2-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGGATGGCATCTGCAGGATCA	0.592000													8	21					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73046169	73046169	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:73046169G>A	ENST00000261180.4	+	16	2704	c.2608G>A	c.(2608-2610)Gaa>Aaa	p.E870K		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	870					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GGATGTCTGGGAATTCATATG	0.378000													28	84					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125530386	125530386	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:125530386G>A	ENST00000431078.1	+	17	2905	c.2541G>A	c.(2539-2541)gaG>gaA	p.E847E		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	847	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTCCTTCAGAGATCACCTTTG	0.488000													17	68					0	0	1	0	0
TNNI3	7137	broad.mit.edu	37	19	55666111	55666111	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55666111C>T	ENST00000344887.5	-	6	512	c.370G>A	c.(370-372)Gag>Aag	p.E124K	TNNI3_ENST00000588882.1_Missense_Mutation_p.E99K	NM_000363.4	NP_000354.4	P19429	TNNI3_HUMAN	troponin I type 3 (cardiac)	124					cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CGTCCCACCTCCGTGATGTTC	0.582000													5	18					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98421634	98421634	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:98421634C>T	ENST00000186436.5	-	22	2547	c.2319G>A	c.(2317-2319)caG>caA	p.Q773Q		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	773						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						ACATATCTTCCTGCATGGCTA	0.408000													6	30					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579461	55579461	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55579461G>A	ENST00000333973.2	+	1	608	c.519G>A	c.(517-519)gtG>gtA	p.V173V		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				GATCTAATGTGATTAACCACT	0.453000													80	223					0	0	1	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48896915	48896915	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:48896915G>A	ENST00000394754.1	+	9	3259	c.3145G>A	c.(3145-3147)Gaa>Aaa	p.E1049K	GTF2A1L_ENST00000403751.3_Missense_Mutation_p.E345K|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.E1049K|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.E1002K|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.E1049K|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.E1049K|GTF2A1L_ENST00000430487.2_Missense_Mutation_p.E311K	NM_172311.2	NP_758515.1	B7ZL16	B7ZL16_HUMAN		1002					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(22)|liver(2)|lung(49)|ovary(3)|pancreas(1)|prostate(4)|skin(4)	91		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TGATATTGGTGAAATAATTCA	0.338000													58	137					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171083178	171083178	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171083178G>A	ENST00000367755.4	+	7	970	c.859G>A	c.(859-861)Gag>Aag	p.E287K	FMO3_ENST00000538429.1_Missense_Mutation_p.E224K|FMO3_ENST00000542847.1_Missense_Mutation_p.E267K|FMO3_ENST00000392085.2_Missense_Mutation_p.E287K	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	287					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTTAACGATGAGCTCCCAGC	0.413000													22	48					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120502576	120502576	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:120502576C>T	ENST00000397558.2	+	4	802	c.802C>T	c.(802-804)Cgt>Tgt	p.R268C	CCDC64_ENST00000446727.2_Missense_Mutation_p.R12C	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	268					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGGAGCATCGTCTCAGCGC	0.567000													19	138					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56334725	56334725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56334725C>T	ENST00000331886.5	+	13	1516	c.1062C>T	c.(1060-1062)acC>acT	p.T354T	DGKA_ENST00000394147.1_Silent_p.T354T|DGKA_ENST00000551156.1_Silent_p.T354T|DGKA_ENST00000549079.2_3'UTR	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	354					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	GCCAGAAGACCATGGATGATT	0.493000											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	49					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417157	150417157	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150417157C>T	ENST00000307194.5	+	3	205	c.65C>T	c.(64-66)tCc>tTc	p.S22F		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1									p.S22Y(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AACGCTCAGTCCCGGCAGGAG	0.527000													96	289					0	0	1	0	0
NOBOX	135935	broad.mit.edu	37	7	144098263	144098263	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:144098263C>T	ENST00000467773.1	-	4	719	c.720G>A	c.(718-720)ggG>ggA	p.G240G	NOBOX_ENST00000223140.5_Silent_p.G155G|NOBOX_ENST00000483238.1_Silent_p.G240G	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	240					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					GGTGGCAGGGCCCCCGGCCTG	0.597000													11	17					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35131484	35131484	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:35131484G>A	ENST00000436258.1	-	0	1885																											TCGTAAAGTGGATGATTCACA	0.418000													23	63					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16034646	16034646	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16034646G>A	ENST00000326742.7	-	6	895	c.894C>T	c.(892-894)ttC>ttT	p.F298F	CYP4F11_ENST00000402119.3_Silent_p.F298F|CYP4F11_ENST00000248041.7_Silent_p.F298F			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	298					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						GCACATCAATGAAGTCTAAAG	0.463000													50	167					0	0	1	0	0
OR10H1	26539	broad.mit.edu	37	19	15918696	15918696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15918696C>T	ENST00000334920.2	-	1	240	c.152G>A	c.(151-153)aGc>aAc	p.S51N		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						GCTGCGCTCGCTCCAGACGGT	0.622000													36	69					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115341664	115341664	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115341664G>A	ENST00000351270.3	+	9	964	c.868G>A	c.(868-870)Gag>Aag	p.E290K	HABP2_ENST00000542051.1_Missense_Mutation_p.E264K|HABP2_ENST00000541666.1_Intron	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	290					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		AAGCCCCACTGAGCCATCAAC	0.527000													58	162					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936890	15936890	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:15936890C>T	ENST00000504595.1	+	4	1552	c.1071C>T	c.(1069-1071)atC>atT	p.I357I	FBXL7_ENST00000329673.7_Silent_p.I345I|FBXL7_ENST00000510662.1_Silent_p.I310I	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	357					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.I357I(1)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						ACCTGAGCATCGCGCACTGCG	0.672000													6	20					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20620505	20620505	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:20620505G>A	ENST00000504154.1	+	37	4715	c.4463G>A	c.(4462-4464)gGa>gAa	p.G1488E	SLIT2_ENST00000273739.5_Missense_Mutation_p.G1501E|SLIT2_ENST00000503823.1_Missense_Mutation_p.G1480E|SLIT2_ENST00000503837.1_Missense_Mutation_p.G1484E	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1488	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GGGTGTGCAGGAGGGCAGTGC	0.532000													20	33					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73844510	73844510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73844510G>A	ENST00000334126.7	-	6	1274	c.1048C>T	c.(1048-1050)Cat>Tat	p.H350Y	C2CD3_ENST00000313663.7_Missense_Mutation_p.H350Y|C2CD3_ENST00000539061.1_Missense_Mutation_p.H350Y			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	350						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					ATAGGAGGATGAACTTGGTCC	0.393000													14	56					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2716283	2716283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2716283G>A	ENST00000399655.1	+	26	3608	c.3343G>A	c.(3343-3345)Gaa>Aaa	p.E1115K	CACNA1C_ENST00000399637.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000480911.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000335762.5_Missense_Mutation_p.E1140K|CACNA1C_ENST00000399603.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399649.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399595.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399606.1_Missense_Mutation_p.E1135K|CACNA1C_ENST00000399601.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399617.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000344100.3_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399621.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399629.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000327702.7_Missense_Mutation_p.E1115K|CACNA1C_ENST00000406454.3_Missense_Mutation_p.E1115K|CACNA1C_ENST00000402845.3_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399597.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000347598.4_Missense_Mutation_p.E1135K|CACNA1C_ENST00000399641.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399638.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399644.1_Missense_Mutation_p.E1115K|CACNA1C_ENST00000399591.1_Missense_Mutation_p.E1115K|CACNA1C-AS3_ENST00000543559.1_RNA|CACNA1C_ENST00000399634.1_Missense_Mutation_p.E1115K	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1135	Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CTCCACCTTCGAAGGGTGGCC	0.542000													7	16					0	0	1	0	0
PPT1	5538	broad.mit.edu	37	1	40555170	40555170	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40555170G>A	ENST00000433473.3	-	5	912	c.448C>T	c.(448-450)Cct>Tct	p.P150S	PPT1_ENST00000449045.2_Missense_Mutation_p.P47S	NM_000310.3	NP_000301.1	P50897	PPT1_HUMAN	palmitoyl-protein thioesterase 1	150					brain development|cofactor metabolic process|cofactor transport|DNA fragmentation involved in apoptotic nuclear change|lysosomal lumen acidification|membrane raft organization|negative regulation of cell growth|negative regulation of neuron apoptosis|neuron development|pinocytosis|positive regulation of pinocytosis|positive regulation of receptor-mediated endocytosis|protein depalmitoylation|protein transport|receptor-mediated endocytosis|regulation of synapse structure and activity|sphingolipid catabolic process|visual perception	axon|cytosol|Golgi apparatus|lysosome|membrane fraction|membrane raft|nucleus|synaptic vesicle	palmitoyl-(protein) hydrolase activity|palmitoyl-CoA hydrolase activity			endometrium(5)|large_intestine(1)|lung(3)|ovary(1)|stomach(1)	11	Lung NSC(20;3.43e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1e-18)|Epithelial(16;3.6e-17)|all cancers(16;1.1e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGGCATCGAGGGAGTCCAAAA	0.443000													18	65					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125288790	125288790	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125288790G>A	ENST00000304880.2	-	1	782	c.783C>T	c.(781-783)ccC>ccT	p.P261P		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						AGGCAATGGAGGGAGGACACA	0.527000													9	58					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49169754	49169754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49169754G>A	ENST00000307885.4	-	8	2492	c.1798C>T	c.(1798-1800)Cgc>Tgc	p.R600C	ADCY6_ENST00000357869.3_Missense_Mutation_p.R600C|ADCY6_ENST00000552090.1_5'UTR|ADCY6_ENST00000550422.1_Missense_Mutation_p.R600C	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	600					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						ACCATCTGGCGGAAGGCCTTG	0.607000													4	11					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31750138	31750138	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:31750138G>A	ENST00000446923.2	+	2	571	c.180G>A	c.(178-180)ggG>ggA	p.G60G	ZEB1_ENST00000361642.5_Silent_p.G77G|ZEB1_ENST00000542815.3_Intron|ZEB1_ENST00000320985.10_Silent_p.G77G|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000560721.2_Silent_p.G77G	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	77					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAGAGAAGGGAATGCTAAGA	0.388000													14	39					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57494895	57494895	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:57494895C>T	ENST00000351747.2	-	6	694	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	DNAH12_ENST00000311202.6_Missense_Mutation_p.E172K|DNAH12_ENST00000389536.4_Missense_Mutation_p.E172K	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	172	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						GGACCTCCTTCATCTTCAAGC	0.313000													23	75					0	0	1	0	0
KRT7	3855	broad.mit.edu	37	12	52636807	52636807	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52636807C>T	ENST00000331817.5	+	6	1053	c.870C>T	c.(868-870)ctC>ctT	p.L290L		NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7	290	Coil 2.|Rod.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		TTGAGACCCTCCAGGCCCAGG	0.587000													18	76					0	0	1	0	0
OR1J1	347168	broad.mit.edu	37	9	125239414	125239414	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125239414G>A	ENST00000259357.2	-	1	821	c.792C>T	c.(790-792)tcC>tcT	p.S264S		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						TGGTGTTGCTGGATGGGGGAA	0.418000													48	98					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120363267	120363267	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120363267G>A	ENST00000283871.5	-	10	1132	c.673C>T	c.(673-675)Cgt>Tgt	p.R225C		NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	225			R -> H (in AKU).		L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		AAGAAATCACGAGGATTGGCC	0.443000													25	66					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887590	97887590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97887590G>A	ENST00000356526.2	+	1	47	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						GTTCTCACAGGATTTTTATAT	0.393000													64	191					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467808	74467808	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74467808G>A	ENST00000249842.3	+	2	966	c.609G>A	c.(607-609)ccG>ccA	p.P203P	RP11-665J16.1_ENST00000561647.1_RNA|ISLR_ENST00000395118.1_Silent_p.P203P	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	203	LRRCT.				cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						TGTCCATCCCGGAGCAGGACA	0.662000													14	49					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89979993	89979993	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:89979993G>A	ENST00000405460.2	+	28	6351	c.6255G>A	c.(6253-6255)gcG>gcA	p.A2085A		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2085					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTTAGTAGCGAAAGTACAGA	0.333000													11	20					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160917778	160917778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160917778C>T	ENST00000368029.3	-	7	823	c.766G>A	c.(766-768)Gag>Aag	p.E256K	RP11-544M22.1_ENST00000356006.3_RNA|ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	256	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCTGCTCTCTCGTTATTAAAC	0.463000													12	96					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488490	108488490	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108488490C>T	ENST00000408999.3	+	20	4107	c.4030C>T	c.(4030-4032)Cta>Tta	p.L1344L	RGPD4_ENST00000354986.4_Silent_p.L1344L	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1344	RanBD1 2.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TTTACCTGATCTAGTTGAAGT	0.393000													113	278					0	0	1	0	0
ZNF442	79973	broad.mit.edu	37	19	12460892	12460892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12460892G>A	ENST00000242804.4	-	6	2089	c.1507C>T	c.(1507-1509)Ctt>Ttt	p.L503F	ZNF442_ENST00000438182.1_Missense_Mutation_p.L434F	NM_030824.2	NP_110451.1	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	503					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	31						TGTTGAGAAAGGTATGTGAAA	0.353000													36	140					0	0	1	0	0
SIPA1	6494	broad.mit.edu	37	11	65417935	65417935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65417935G>A	ENST00000394224.3	+	15	3263	c.2967G>A	c.(2965-2967)caG>caA	p.Q989Q	SIPA1_ENST00000527525.1_Silent_p.Q887Q|SIPA1_ENST00000394227.3_Silent_p.Q887Q|SIPA1_ENST00000534313.1_Silent_p.Q989Q	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	989					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GGAAGCTGCAGGAGGACCTGC	0.632000													15	53					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57815731	57815731	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57815731G>A	ENST00000281282.5	+	11	2838	c.2760G>A	c.(2758-2760)gaG>gaA	p.E920E		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	920						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGTTGTCTGAGAAGCTCAAAG	0.512000													15	29					0	0	1	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37962694	37962694	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37962694C>T	ENST00000249014.4	+	2	758	c.338C>T	c.(337-339)tCc>tTc	p.S113F		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	113					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					CCGGCCATCTCCCCCATCATC	0.682000													40	109					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93819207	93819207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93819207C>T	ENST00000315765.9	+	11	1940	c.1932C>T	c.(1930-1932)tcC>tcT	p.S644S		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	644	Plastocyanin-like 4.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATAGAGTTTCCTGGCATCTGA	0.468000													14	42					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54784155	54784155	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54784155C>T	ENST00000391748.1	-	3	162		c.e3-1		LILRB2_ENST00000434421.1_Intron|LILRB2_ENST00000391746.1_Splice_Site|LILRB2_ENST00000314446.5_Splice_Site|LILRB2_ENST00000391749.4_Splice_Site|LILRB2_ENST00000471216.1_5'UTR	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2						cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGACTCAGCCCTGGAAGAGAG	0.647000													8	115					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72164243	72164243	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:72164243C>T	ENST00000537465.1	-	12	1824	c.1666G>A	c.(1666-1668)Gag>Aag	p.E556K	PMFBP1_ENST00000355636.6_Missense_Mutation_p.E406K|PMFBP1_ENST00000237353.10_Missense_Mutation_p.E551K			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	556										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				AATGACAGCTCCTCCACCCGT	0.478000													25	41					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67380159	67380159	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67380159G>A	ENST00000329956.6	+	3	218	c.198_splice	c.e3-1	p.G67_splice	LRRC36_ENST00000563303.1_3'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	67										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TTCCTTGTAGGGAATCCAGTA	0.363000													23	74					0	0	1	0	0
BDH1	622	broad.mit.edu	37	3	197273245	197273245	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:197273245C>T	ENST00000392379.1	-	3	471	c.70G>A	c.(70-72)Gaa>Aaa	p.E24K	BDH1_ENST00000392378.2_Missense_Mutation_p.E24K|BDH1_ENST00000358186.2_Missense_Mutation_p.E24K|BDH1_ENST00000441275.1_Intron	NM_203314.2	NP_976059.1	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	24					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	GCTCCATTTTCTCTATCACAG	0.557000													43	39					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227400879	227400879	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:227400879G>A	ENST00000366769.3	-	3	1603	c.312C>T	c.(310-312)gcC>gcT	p.A104A	CDC42BPA_ENST00000334218.5_Silent_p.A104A|CDC42BPA_ENST00000366767.3_Silent_p.A104A|CDC42BPA_ENST00000366765.3_Silent_p.A104A|CDC42BPA_ENST00000366766.2_Silent_p.A104A|CDC42BPA_ENST00000366764.2_Silent_p.A104A|CDC42BPA_ENST00000535525.1_Silent_p.A104A	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	104	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				ATATTTTCATGGCAAACACTT	0.244000													15	108					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461349	11461349	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:11461349C>T	ENST00000279575.1	-	3	601	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	PRB4_ENST00000535904.1_Missense_Mutation_p.E190K|PRB4_ENST00000445719.2_Missense_Mutation_p.E121K	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	253	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						TTGTTGCCTTCTTGTTGGGGT	0.602000										HNSCC(22;0.051)			83	252					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179428916	179428916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179428916C>T	ENST00000589042.1	-	326	82167	c.81943G>A	c.(81943-81945)Gaa>Aaa	p.E27315K	TTN_ENST00000342992.6_Missense_Mutation_p.E24747K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E18250K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E18442K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E18375K|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E25674K|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	25674	Fibronectin type-III 99.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCAAGTTCTTTTCCATCT	0.378000													60	177					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641355	179641355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179641355C>T	ENST00000589042.1	-	28	5460	c.5236G>A	c.(5236-5238)Gaa>Aaa	p.E1746K	TTN_ENST00000342992.6_Missense_Mutation_p.E1746K|TTN_ENST00000360870.5_Missense_Mutation_p.E1746K|TTN_ENST00000460472.2_Missense_Mutation_p.E1700K|TTN_ENST00000342175.6_Missense_Mutation_p.E1700K|TTN_ENST00000359218.5_Missense_Mutation_p.E1700K|TTN_ENST00000591111.1_Missense_Mutation_p.E1746K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1500	Ig-like 8.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGCTGCTTCAAGTGGCTTT	0.493000													15	50					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160920888	160920888	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160920888C>T	ENST00000368029.3	-	4	443	c.386G>A	c.(385-387)tGg>tAg	p.W129*		NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	129	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTAGTTGGCCCAGTTGCCATC	0.582000													30	85					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53072446	53072446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53072446G>A	ENST00000252244.3	-	2	744	c.686C>T	c.(685-687)cCc>cTc	p.P229L		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	229	Linker 1.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CTCAAAGTAGGGCTCTAAATT	0.468000													16	100					0	0	1	0	0
ALDH2	217	broad.mit.edu	37	12	112219820	112219820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:112219820G>A	ENST00000546840.2	+	3	203	c.203G>A	c.(202-204)gGg>gAg	p.G68E	ALDH2_ENST00000261733.2_Silent_p.G71G|ALDH2_ENST00000416293.3_Silent_p.G71G																							TAGCTGAAGGGGACAAGGTGA	0.448000													15	47					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62423883	62423883	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:62423883G>A	ENST00000383710.4	-	28	4022	c.3673C>T	c.(3673-3675)Ccc>Tcc	p.P1225S	CADPS_ENST00000357948.3_Missense_Mutation_p.P1146S|CADPS_ENST00000283269.9_Missense_Mutation_p.P1186S	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1225	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCCATCCCGGGTTTCTGTAAA	0.468000													18	45					0	0	1	0	0
RAB27B	5874	broad.mit.edu	37	18	52556597	52556597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:52556597G>A	ENST00000262094.5	+	6	1131	c.610G>A	c.(610-612)Gga>Aga	p.G204R	RP11-839G9.1_ENST00000588466.1_RNA	NM_004163.4	NP_004154.2	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	204					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity			large_intestine(3)|lung(3)|skin(1)	7				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		TGGAAATTCTGGAAACTTGGA	0.398000													25	62					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56385698	56385698	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:56385698G>A	ENST00000423270.1	-	9	4227	c.4228C>T	c.(4228-4230)Cgt>Tgt	p.R1410C	RFX7_ENST00000317318.6_Intron|RFX7_ENST00000422057.1_Intron|RFX7_ENST00000559447.2_Missense_Mutation_p.R1313C	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	1313					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CCCTGCTGACGACCTGGATCA	0.398000													13	44					0	0	1	0	0
MAP7D2	256714	broad.mit.edu	37	X	20081589	20081589	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:20081589C>T	ENST00000379651.3	-	3	333	c.315G>A	c.(313-315)gaG>gaA	p.E105E	MAP7D2_ENST00000443379.3_Silent_p.E105E|MAP7D2_ENST00000379643.5_Silent_p.E105E|MAP7D2_ENST00000452324.3_Silent_p.E61E	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	105										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						TCTTTTGGTCCTCCCGCTGCC	0.577000													31	21					0	0	1	0	0
FAM154B	283726	broad.mit.edu	37	15	82574877	82574877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:82574877C>T	ENST00000339465.5	+	3	740	c.671C>T	c.(670-672)cCa>cTa	p.P224L	FAM154B_ENST00000427381.2_Missense_Mutation_p.P209L|FAM154B_ENST00000565501.1_3'UTR	NM_001008226.1	NP_001008227.1	Q658L1	F154B_HUMAN	family with sequence similarity 154, member B	224										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						AGTTTTCAACCATGGGAAATC	0.463000													26	99					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37871608	37871608	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37871608C>T	ENST00000406381.2	+	12	1638	c.1128C>T	c.(1126-1128)atC>atT	p.I376I	ERBB2_ENST00000269571.5_Silent_p.I406I|ERBB2_ENST00000578199.1_Silent_p.I376I|ERBB2_ENST00000541774.1_Silent_p.I391I|ERBB2_ENST00000540147.1_Silent_p.I376I|ERBB2_ENST00000445658.2_Silent_p.I130I|ERBB2_ENST00000584601.1_Silent_p.I376I|ERBB2_ENST00000584450.1_Silent_p.I406I|ERBB2_ENST00000540042.1_Silent_p.I376I	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	406					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TGGAAGAGATCACAGGTGGGC	0.592000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			14	24					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201035010	201035010	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201035010G>A	ENST00000362061.3	-	22	3035	c.2809C>T	c.(2809-2811)Ctc>Ttc	p.L937F	CACNA1S_ENST00000367338.3_Missense_Mutation_p.L937F	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	937					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AACTGTAGGAGGGTAGTGACC	0.647000													10	24					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89878700	89878700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:89878700G>A	ENST00000345097.4	-	2	237	c.121C>T	c.(121-123)Ctc>Ttc	p.L41F	FOXN3_ENST00000557258.1_Missense_Mutation_p.L41F|FOXN3_ENST00000555353.1_Missense_Mutation_p.L41F|FOXN3_ENST00000261302.5_Missense_Mutation_p.L41F|RP11-33N16.3_ENST00000555070.1_RNA	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	41					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GAAAAGTCGAGGTCATCGTCT	0.522000													54	101					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	145001	145001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145001C>T	ENST00000283426.6	+	4	853	c.803C>T	c.(802-804)gCc>gTc	p.A268V		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	268					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGTCCAGCTGCCCCTGCCGTC	0.607000													15	36					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28971156	28971156	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28971156C>T	ENST00000359747.4	+	7	829	c.800C>T	c.(799-801)cCc>cTc	p.P267L	DSG4_ENST00000308128.4_Missense_Mutation_p.P267L|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	267	Cadherin 2.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GATAATTTCCCCACCTTAGAG	0.398000													20	81					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77270191	77270191	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77270191G>A	ENST00000251089.2	-	6	1557	c.1445C>T	c.(1444-1446)cCc>cTc	p.P482L	ANGEL1_ENST00000557179.1_Missense_Mutation_p.P47L	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	482										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CAGGGAGCTGGGCCACAGTGG	0.527000													60	147					0	0	1	0	0
TMEM211	255349	broad.mit.edu	37	22	25334143	25334143	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25334143G>A	ENST00000407886.1	-	3	352	c.100C>T	c.(100-102)Cca>Tca	p.P34S	TMEM211_ENST00000382744.1_Missense_Mutation_p.P34S|TMEM211_ENST00000423535.1_Missense_Mutation_p.P105S			Q6ICI0	TM211_HUMAN	transmembrane protein 211	105						integral to membrane				endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	8						CCTGGCATTGGAACACTGCTT	0.512000													14	77					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150698983	150698983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150698983C>T	ENST00000297494.3	+	13	1934	c.1577C>T	c.(1576-1578)tCc>tTc	p.S526F	NOS3_ENST00000461406.1_Missense_Mutation_p.S320F|NOS3_ENST00000467517.1_Missense_Mutation_p.S526F|NOS3_ENST00000484524.1_Missense_Mutation_p.S526F	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	526	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CTGTATGGCTCCGAGACCGGC	0.652000													27	49					0	0	1	0	0
TMEM107	84314	broad.mit.edu	37	17	8079185	8079185	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8079185G>A	ENST00000316425.5	-	3	276	c.164C>T	c.(163-165)cCt>cTt	p.P55L	TMEM107_ENST00000533070.1_Missense_Mutation_p.P55L|TMEM107_ENST00000449985.2_Intron|TMEM107_ENST00000437139.2_Intron|TMEM107_ENST00000431792.2_Intron|TMEM107_ENST00000532998.1_Intron	NM_032354.3	NP_115730.2	Q6UX40	TM107_HUMAN	transmembrane protein 107	51						integral to membrane				large_intestine(1)|lung(4)|ovary(1)	6						CCTGCAGAGAGGAAGTGGACT	0.602000													45	48					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182444	140182444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140182444C>T	ENST00000522353.2	+	1	1662	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F	PCDHA3_ENST00000532566.2_Silent_p.F554F|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1												p.F554F(2)		NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGTGTTCGTGCTGGACG	0.687000													19	156					0	0	1	0	0
LRRC55	219527	broad.mit.edu	37	11	56950108	56950108	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56950108G>A	ENST00000497933.1	+	1	888	c.741G>A	c.(739-741)atG>atA	p.M247I		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	217	LRRCT.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						GCTGCACCATGGAACCCCTGC	0.632000													38	102					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038129	75038129	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:75038129C>T	ENST00000326665.5	-	14	3483	c.3265G>A	c.(3265-3267)Gaa>Aaa	p.E1089K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1089	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AAAGCATCTTCATCCTTGAGT	0.433000													74	184					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118372518	118372518	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118372518C>T	ENST00000534358.1	+	26	6474	c.6451C>T	c.(6451-6453)Ccc>Tcc	p.P2151S	KMT2A_ENST00000389506.5_Missense_Mutation_p.P2148S|KMT2A_ENST00000354520.4_Missense_Mutation_p.P2110S	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GATTCGAACACCCAGTTATTC	0.463000													56	149					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168833388	168833388	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168833388G>A	ENST00000464456.1	-	7	2908	c.1708C>T	c.(1708-1710)Ccc>Tcc	p.P570S	MECOM_ENST00000433243.2_Missense_Mutation_p.P571S|MECOM_ENST00000460814.1_Missense_Mutation_p.P570S|MECOM_ENST00000392736.3_Missense_Mutation_p.P570S|MECOM_ENST00000472280.1_Missense_Mutation_p.P571S|MECOM_ENST00000264674.3_Missense_Mutation_p.P635S|MECOM_ENST00000468789.1_Missense_Mutation_p.P570S|MECOM_ENST00000494292.1_Missense_Mutation_p.P758S	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GGCTTGGAGGGGACTGGAGTC	0.547000													14	54					0	0	1	0	0
ZP3	7784	broad.mit.edu	37	7	76062806	76062806	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76062806G>A	ENST00000416245.1	+	3	1120	c.27G>A	c.(25-27)aaG>aaA	p.K9K	ZP3_ENST00000336517.4_Silent_p.K134K|ZP3_ENST00000394857.3_Silent_p.K185K			P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 (sperm receptor)	185					binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7						ACGCTGAGAAGAGGTCCCCCA	0.597000													6	117					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30066932	30066932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:30066932G>A	ENST00000331968.5	-	16	2428	c.2199C>T	c.(2197-2199)atC>atT	p.I733I	PRKD1_ENST00000415220.2_Silent_p.I741I	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	733	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCTCTCCAATGATCCGGGCAA	0.468000													26	50					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26524815	26524815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:26524815C>T	ENST00000456354.2	+	6	784	c.717C>T	c.(715-717)ttC>ttT	p.F239F		NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	239					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		TTGGTGCATTCGTGCCCAAGC	0.512000													132	311					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371007	240371007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240371007C>T	ENST00000319653.9	+	5	3125	c.2895C>T	c.(2893-2895)ccC>ccT	p.P965P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	965	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGGCATACCCCTTCCTCCCC	0.701000													26	80					0	0	1	0	0
TROVE2	6738	broad.mit.edu	37	1	193046046	193046046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:193046046C>T	ENST00000432079.1	+	4	695	c.127C>T	c.(127-129)Cgt>Tgt	p.R43C	TROVE2_ENST00000460715.2_3'UTR|TROVE2_ENST00000367441.1_Missense_Mutation_p.R318C|TROVE2_ENST00000367446.3_Missense_Mutation_p.R318C|TROVE2_ENST00000367444.3_Missense_Mutation_p.R318C|TROVE2_ENST00000367445.3_Missense_Mutation_p.R318C|TROVE2_ENST00000416058.2_Missense_Mutation_p.R43C|TROVE2_ENST00000400968.2_Missense_Mutation_p.R318C|TROVE2_ENST00000367443.1_Missense_Mutation_p.R318C			P10155	RO60_HUMAN	TROVE domain family, member 2	318	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						TTTCTAGGCTCGTATACATCC	0.328000													4	41					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124371873	124371873	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124371873G>A	ENST00000287394.5	-	10	1317	c.1210C>T	c.(1210-1212)Cga>Tga	p.R404*	ATAD2_ENST00000534257.1_5'UTR|ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ATTTTCATTCGATCTTTATAA	0.353000													13	60					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152524385	152524385	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152524385C>T	ENST00000427231.2	-	40	4854	c.4652G>A	c.(4651-4653)gGc>gAc	p.G1551D	NEB_ENST00000409198.1_Missense_Mutation_p.G1551D|NEB_ENST00000397345.3_Missense_Mutation_p.G1551D|NEB_ENST00000604864.1_Missense_Mutation_p.G1551D|NEB_ENST00000172853.10_Missense_Mutation_p.G1551D|NEB_ENST00000603639.1_Missense_Mutation_p.G1551D	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	1551					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CAAATCATAGCCCTTGGCAAT	0.333000													15	37					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81744902	81744902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81744902C>T	ENST00000555447.1	-	6	1165	c.753G>A	c.(751-753)ctG>ctA	p.L251L	STON2_ENST00000556280.1_5'UTR|STON2_ENST00000267540.2_Silent_p.L251L	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	251					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TATTTGGCTTCAGAGGAGAGG	0.502000													10	85					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075383	9075383	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9075383G>A	ENST00000397910.4	-	3	12266	c.12063C>T	c.(12061-12063)agC>agT	p.S4021S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4023	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCATGTAAGGGCTGACGTCCC	0.463000													21	70					0	0	1	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266308	3266308	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3266308G>A	ENST00000576468.1	+	0	418																											ACAAAGGGAAGATGGAAAGCC	0.527000													15	43					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37724314	37724314	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:37724314G>A	ENST00000539465.1	+	7	1202	c.609G>A	c.(607-609)gtG>gtA	p.V203V	FRMPD1_ENST00000541302.1_Silent_p.V72V|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000536622.1_Silent_p.V25V|FRMPD1_ENST00000377765.3_Silent_p.V203V			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	203	FERM.					cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		ACACAACCGTGAAGGTATTAA	0.463000													7	44					0	0	1	0	0
SEMA4A	64218	broad.mit.edu	37	1	156128250	156128250	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156128250C>T	ENST00000368285.3	+	5	702	c.435C>T	c.(433-435)ttC>ttT	p.F145F	SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000368282.1_Silent_p.F145F|SEMA4A_ENST00000368286.2_Intron|SEMA4A_ENST00000355014.2_Silent_p.F145F|SEMA4A_ENST00000368284.1_Intron	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	145	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					GCGGCACCTTCGCCTTCAGCC	0.522000													56	167					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49639110	49639110	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49639110C>T	ENST00000334186.4	+	14	1944	c.1595C>T	c.(1594-1596)cCc>cTc	p.P532L	PPFIA3_ENST00000602351.1_Missense_Mutation_p.P532L	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	532						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CACCTGGATCCCTATGTGGCT	0.627000													29	63					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124330411	124330411	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124330411C>T	ENST00000368909.3	+	4	251	c.145C>T	c.(145-147)Cca>Tca	p.P49S	DMBT1_ENST00000330163.4_Missense_Mutation_p.P49S|DMBT1_ENST00000368955.3_Missense_Mutation_p.P49S|DMBT1_ENST00000359586.6_Missense_Mutation_p.P49S|DMBT1_ENST00000368956.2_Missense_Mutation_p.P49S|DMBT1_ENST00000344338.3_Missense_Mutation_p.P49S|DMBT1_ENST00000338354.3_Missense_Mutation_p.P49S	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	49					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGCAGGTTCTCCATTTCCCTC	0.552000													60	135					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19566125	19566125	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19566125C>T	ENST00000328041.6	+	6	746	c.549C>T	c.(547-549)atC>atT	p.I183I		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	183						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTGGCACCATCGTGGGCTCAG	0.542000													22	183					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120969581	120969581	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120969581G>A	ENST00000273666.6	+	15	1683	c.1412G>A	c.(1411-1413)gGa>gAa	p.G471E	STXBP5L_ENST00000471454.1_Missense_Mutation_p.G471E|STXBP5L_ENST00000492541.1_Missense_Mutation_p.G471E|STXBP5L_ENST00000497029.1_Missense_Mutation_p.G471E|STXBP5L_ENST00000472879.1_Missense_Mutation_p.G471E	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	471					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CATGCAGATGGATCAATAAAA	0.294000													10	34					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52498066	52498066	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:52498066C>T	ENST00000261839.7	-	37	4645	c.4484G>A	c.(4483-4485)cGa>cAa	p.R1495Q	RP11-430B1.2_ENST00000560518.1_lincRNA	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1495	Dilute.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		ATGATATATTCGTATAGCCAC	0.303000													17	61					0	0	1	0	0
UBAC2	337867	broad.mit.edu	37	13	99992680	99992680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:99992680C>T	ENST00000376440.2	+	5	1066	c.563C>T	c.(562-564)tCt>tTt	p.S188F	UBAC2_ENST00000403766.3_Missense_Mutation_p.S223F|UBAC2_ENST00000460562.1_3'UTR	NM_177967.3	NP_808882.1	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2	223						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)	10	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCCATCTTCTCTTCTTCAGAA	0.532000													12	109					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100821706	100821706	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:100821706G>A	ENST00000358544.2	+	44	8231	c.8120G>A	c.(8119-8121)cGa>cAa	p.R2707Q	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.R2682Q	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2707					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TACAGGGGTCGAACTGCTTCT	0.438000													37	59					0	0	1	0	0
SNX8	29886	broad.mit.edu	37	7	2302930	2302930	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2302930G>A	ENST00000222990.3	-	7	892	c.850C>T	c.(850-852)Ctg>Ttg	p.L284L		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	284					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		GCCTGCTTCAGGGACCCCCAC	0.617000													9	34					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50884459	50884459	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50884459G>A	ENST00000313478.7	-	26	4254	c.3973C>T	c.(3973-3975)Ccc>Tcc	p.P1325S	TRPM7_ENST00000560955.1_Missense_Mutation_p.P1325S	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	1325					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TTACACTGGGGATCTTTGTCA	0.378000													39	86					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196865582	196865582	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196865582G>A	ENST00000312428.6	-	12	1299	c.1199C>T	c.(1198-1200)cCa>cTa	p.P400L	DNAH7_ENST00000410072.1_Missense_Mutation_p.P400L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	400	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GATGAAACCTGGATGTTCAAA	0.323000													36	95					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71135091	71135091	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:71135091G>A	ENST00000333538.5	+	8	2035	c.1401G>A	c.(1399-1401)ggG>ggA	p.G467G	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	467	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TTGCTTACGGGGAGGTAATTC	0.418000													75	179					0	0	1	0	0
STIM2	57620	broad.mit.edu	37	4	27010620	27010620	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:27010620T>A	ENST00000382009.3	+	11	2037	c.1770T>A	c.(1768-1770)ttT>ttA	p.F590L	STIM2_ENST00000465503.1_Missense_Mutation_p.F503L|STIM2_ENST00000237364.5_Missense_Mutation_p.F582L|STIM2_ENST00000412829.2_Missense_Mutation_p.F582L|STIM2_ENST00000467011.1_Missense_Mutation_p.F495L|STIM2_ENST00000467087.1_Missense_Mutation_p.F495L	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	495					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				TGTCACAATTTCCCGGTAAGT	0.418000													34	83					0	0	1	0	0
DPP4	1803	broad.mit.edu	37	2	162851822	162851822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:162851822C>T	ENST00000360534.3	-	24	2673	c.2113G>A	c.(2113-2115)Gga>Aga	p.G705R	DPP4_ENST00000491591.1_5'UTR	NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	705					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	TCTGCTGTTCCATGAATAAGG	0.363000													38	115					0	0	1	0	0
PHLPP1	23239	broad.mit.edu	37	18	60645858	60645858	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:60645858C>T	ENST00000400316.4	+	17	4593	c.2812C>T	c.(2812-2814)Ccc>Tcc	p.P938S	PHLPP1_ENST00000262719.5_Missense_Mutation_p.P1450S	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1450					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						CATCTTTCCTCCCTCAGTGAA	0.627000													9	35					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347212	57347212	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57347212G>A	ENST00000361249.3	+	5	655	c.559G>A	c.(559-561)Gag>Aag	p.E187K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	187	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGAATGGAGGGAGCTTCGATA	0.453000													40	122					0	0	1	0	0
MFAP5	8076	broad.mit.edu	37	12	8814653	8814653	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:8814653G>A	ENST00000359478.2	-	2	235	c.48C>T	c.(46-48)atC>atT	p.I16I	MFAP5_ENST00000433590.2_Silent_p.I16I|MFAP5_ENST00000396549.2_Silent_p.I16I|MFAP5_ENST00000540087.1_Silent_p.I16I|MFAP5_ENST00000543369.1_Silent_p.I16I|MFAP5_ENST00000538107.1_5'UTR|MFAP5_ENST00000535336.1_Silent_p.I16I	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	16						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					CAGAGGTGATGATGAATGCAG	0.512000													10	23					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7571684	7571684	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7571684C>T	ENST00000379802.3	+	14	2111	c.1770C>T	c.(1768-1770)ttC>ttT	p.F590F	DSP_ENST00000418664.2_Silent_p.F590F	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	590	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACCAAGAGTTCATCAGAAATA	0.458000													30	266					0	0	1	0	0
ELANE	1991	broad.mit.edu	37	19	856138	856138	+	Missense_Mutation	SNP	C	C	T	rs143579306	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:856138C>T	ENST00000590230.1	+	6	919	c.778C>T	c.(778-780)Ccg>Tcg	p.P260S	ELANE_ENST00000263621.1_Missense_Mutation_p.P260S			P08246	ELNE_HUMAN	elastase, neutrophil expressed	260					cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(1)|lung(4)|pancreas(1)	13					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CCCCCGGGACCCGGACCCGGC	0.612000													51	186					0	0	1	0	0
DDHD2	23259	broad.mit.edu	37	8	38110573	38110573	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:38110573C>T	ENST00000397166.2	+	15	2344	c.1819C>T	c.(1819-1821)Cct>Tct	p.P607S	DDHD2_ENST00000520272.2_Missense_Mutation_p.P607S|DDHD2_ENST00000529845.1_Missense_Mutation_p.P58S|DDHD2_ENST00000517385.1_Missense_Mutation_p.P226S	NM_015214.2	NP_056029.2	O94830	DDHD2_HUMAN	DDHD domain containing 2	607	DDHD.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)|urinary_tract(2)	28	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			AGCTCCATACCCTGCCTTACA	0.483000													7	65					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40301883	40301883	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40301883C>T	ENST00000263791.5	+	26	3688	c.3645C>T	c.(3643-3645)atC>atT	p.I1215I	EIF2AK4_ENST00000382727.2_Silent_p.I1187I	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1215	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		ACTGTGGGATCCCAGAAGATA	0.313000													48	89					0	0	1	0	0
PCBP2	5094	broad.mit.edu	37	12	53856349	53856349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53856349C>T	ENST00000603815.1	+	8	939	c.589C>T	c.(589-591)Cag>Tag	p.Q197*	PCBP2_ENST00000359282.5_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000541275.1_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000359462.5_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000447282.1_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000546463.1_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000548933.1_Nonsense_Mutation_p.Q197*|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000437231.1_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000552296.2_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000455667.3_Nonsense_Mutation_p.Q193*|PCBP2_ENST00000549863.1_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000552819.1_Nonsense_Mutation_p.Q197*|PCBP2_ENST00000439930.3_Nonsense_Mutation_p.Q197*	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	197					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						TGCAGGTGGTCAGGTAAGAAA	0.512000													11	57					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760700	92760700	+	Missense_Mutation	SNP	C	C	T	rs147406199		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:92760700C>T	ENST00000318238.4	-	5	5801	c.4585G>A	c.(4585-4587)Gct>Act	p.A1529T	SAMD9L_ENST00000411955.1_Missense_Mutation_p.A1529T|SAMD9L_ENST00000437805.1_Missense_Mutation_p.A1529T	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1529										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTGCCTTCAGCCTGACCAGTT	0.398000													22	96					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049324	36049324	+	Silent	SNP	G	G	A	rs148290056	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36049324G>A	ENST00000282507.3	-	4	611	c.510C>T	c.(508-510)ttC>ttT	p.F170F	UGT3A2_ENST00000545528.1_Intron|UGT3A2_ENST00000513300.1_Silent_p.F136F|UGT3A2_ENST00000504954.1_Intron	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	170						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCAAAGAGCCGAATGAAGTGG	0.453000													33	63					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85973846	85973846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85973846C>T	ENST00000372117.3	+	17	2152	c.2049C>T	c.(2047-2049)tcC>tcT	p.S683S	CDHR1_ENST00000440770.2_Silent_p.S387S|CDHR1_ENST00000332904.3_Intron	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	683	Cadherin 6.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						AGACCCTCTCCCGGAGCCCCA	0.582000													41	89					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124193559	124193559	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124193559G>A	ENST00000360013.3	+	26	4202	c.4075G>A	c.(4075-4077)Gga>Aga	p.G1359R	KALRN_ENST00000240874.3_Missense_Mutation_p.G1359R|KALRN_ENST00000460856.1_Missense_Mutation_p.G1350R	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1359	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGAGGATGTGGGACACTGCTT	0.517000													18	53					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224437993	224437993	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:224437993G>A	ENST00000281701.6	-	19	2469	c.2210C>T	c.(2209-2211)cCg>cTg	p.P737L	NVL_ENST00000340871.4_Missense_Mutation_p.P548L|NVL_ENST00000391875.2_Missense_Mutation_p.P631L|NVL_ENST00000361463.3_3'UTR|NVL_ENST00000469075.1_Missense_Mutation_p.P646L|NVL_ENST00000482491.1_Missense_Mutation_p.P461L	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	737						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		CAGGCGGCCCGGGCGCAGGAT	0.393000													26	74					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15448386	15448386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:15448386G>A	ENST00000281513.5	-	40	4776	c.4751C>T	c.(4750-4752)gCc>gTc	p.A1584V	NBAS_ENST00000441750.1_Missense_Mutation_p.A1464V	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1584										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						GGCCAATCGGGCATAGATCTG	0.473000													16	42					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79051844	79051844	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79051844G>A	ENST00000388820.4	-	24	5190	c.4980C>T	c.(4978-4980)atC>atT	p.I1660I		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1660	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						ACTGGGTGCGGATGGTGGGCA	0.721000													4	11					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15375521	15375521	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15375521G>A	ENST00000263377.2	-	6	1127	c.906C>T	c.(904-906)ccC>ccT	p.P302P	BRD4_ENST00000360016.5_Silent_p.P302P|BRD4_ENST00000371835.4_Silent_p.P302P	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	302					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GCTCGTGAATGGGGTCAATGG	0.622000			T	C15orf55	lethal midline carcinoma of young people						OREG0025319	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	180					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882168	228882168	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228882168C>T	ENST00000392056.3	-	7	3448	c.3402G>A	c.(3400-3402)gtG>gtA	p.V1134V	SPHKAP_ENST00000344657.5_Silent_p.V1134V	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1134						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CCATCTGGTTCACCATGAACC	0.527000													17	36					0	0	1	0	0
FKBP2	2286	broad.mit.edu	37	11	64010707	64010707	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64010707C>T	ENST00000394540.3	+	3	678	c.208C>T	c.(208-210)Ctg>Ttg	p.L70L	FKBP2_ENST00000449942.2_Silent_p.L70L|FKBP2_ENST00000309366.4_Silent_p.L70L	NM_057092.2	NP_476433.1	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa	70	PPIase FKBP-type.				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			endometrium(2)|lung(3)	5						TGACAGCAGCCTGCCCCAGAA	0.617000													7	56					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17757553	17757553	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17757553G>A	ENST00000379472.3	+	1	34	c.4G>A	c.(4-6)Ggc>Agc	p.G2S	KCNC1_ENST00000265969.6_Missense_Mutation_p.G2S	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	2						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CGCCGCGATGGGCCAAGGGGA	0.761000													7	8					0	0	1	0	0
NUP62CL	54830	broad.mit.edu	37	X	106396730	106396730	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:106396730G>A	ENST00000372466.4	-	6	600	c.349C>T	c.(349-351)Cgt>Tgt	p.R117C	NUP62CL_ENST00000372461.3_Silent_p.F66F	NM_017681.2	NP_060151.2	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	117					protein transport	nuclear pore	structural constituent of nuclear pore			lung(4)	4						TGTAAAATACGAATCTATAAA	0.259000													18	13					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613628	179613628	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179613628C>T	ENST00000360870.5	-	46	13721	c.13499G>A	c.(13498-13500)aGa>aAa	p.R4500K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	630	Ig-like 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTGATTCTCTTTGCTTTAA	0.318000													37	52					0	0	1	0	0
TNNT1	7138	broad.mit.edu	37	19	55652277	55652277	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55652277C>T	ENST00000588981.1	-	9	565	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K	TNNT1_ENST00000587758.1_Missense_Mutation_p.E110K|TNNT1_ENST00000592920.1_5'UTR|TNNT1_ENST00000291901.8_Missense_Mutation_p.E121K|TNNT1_ENST00000356783.5_Missense_Mutation_p.E110K|TNNT1_ENST00000585321.2_Missense_Mutation_p.E51K|TNNT1_ENST00000536926.1_Missense_Mutation_p.E110K|TNNT1_ENST00000588426.1_Missense_Mutation_p.E18K|TNNT1_ENST00000587465.2_Missense_Mutation_p.E51K	NM_003283.4	NP_003274.3	P13805	TNNT1_HUMAN	troponin T type 1 (skeletal, slow)	121					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CGTTCGCGTTCCTTCTCAGTT	0.562000													22	65					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124360020	124360020	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124360020C>T	ENST00000409039.3	+	46	7852	c.7827C>T	c.(7825-7827)atC>atT	p.I2609I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2609	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATTCCTCCATCCTGAAAGGCC	0.438000													28	84					0	0	1	0	0
MAPK15	225689	broad.mit.edu	37	8	144802954	144802954	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144802954C>T	ENST00000338033.4	+	9	980	c.861C>T	c.(859-861)ttC>ttT	p.F287F		NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	287	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding	p.F306F(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCCTGGTGTTCGCCCCGGACA	0.672000													5	31					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6749241	6749241	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6749241C>T	ENST00000229243.2	-	8	1503	c.1410G>A	c.(1408-1410)ggG>ggA	p.G470G	ACRBP_ENST00000414226.2_Silent_p.G437G|ACRBP_ENST00000542357.1_5'UTR	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	470						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						TAGGGAAATCCCCATCCTGGA	0.542000													9	34					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124045712	124045712	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124045712C>T	ENST00000368994.2	+	5	588	c.337C>T	c.(337-339)Ctg>Ttg	p.L113L	BTBD16_ENST00000260723.4_Silent_p.L112L			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	112										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CCTGAAAGCCCTGGCGCAGGG	0.602000													52	115					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179728597	179728597	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:179728597G>A	ENST00000253778.8	-	19	2185	c.2016C>T	c.(2014-2016)ccC>ccT	p.P672P		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	672	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CCAGATTTCTGGGGAAGTCAA	0.453000													22	81					0	0	1	0	0
DDX59	83479	broad.mit.edu	37	1	200635747	200635747	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:200635747G>A	ENST00000447706.2	-	2	273	c.122C>T	c.(121-123)cCc>cTc	p.P41L	DDX59_ENST00000331314.6_Missense_Mutation_p.P41L|DDX59_ENST00000367348.3_Missense_Mutation_p.P41L			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	41						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						AGCATCAACGGGAACATCTCT	0.468000													50	139					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791484	95791484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95791484G>A	ENST00000260766.3	+	2	1315	c.681G>A	c.(679-681)aaG>aaA	p.K227K	PLCE1_ENST00000371380.2_Silent_p.K227K	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	227					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				AGAAGCAAAAGAAAAACTATG	0.388000													15	57					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152733541	152733541	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152733541G>A	ENST00000368773.1	+	2	1535	c.1477G>A	c.(1477-1479)Gag>Aag	p.E493K	KPRP_ENST00000606109.1_Missense_Mutation_p.E493K	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	493	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCCTGCAGGGAGACTTGGCG	0.652000													35	74					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27197484	27197484	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:27197484C>T	ENST00000380036.4	+	12	2238	c.1796C>T	c.(1795-1797)tCg>tTg	p.S599L	TEK_ENST00000519097.1_Missense_Mutation_p.S452L|TEK_ENST00000406359.4_Missense_Mutation_p.S556L	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	599	Fibronectin type-III 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		AACTTGACTTCGGTGCTACTT	0.463000													50	85					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90872781	90872781	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:90872781T>A	ENST00000394980.1	+	8	3463	c.3144T>A	c.(3142-3144)caT>caA	p.H1048Q	MMRN1_ENST00000508372.1_Missense_Mutation_p.H790Q|MMRN1_ENST00000264790.2_Missense_Mutation_p.H1048Q|MMRN1_ENST00000394981.1_Missense_Mutation_p.H351Q			Q13201	MMRN1_HUMAN	multimerin 1	1048	EGF-like.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GTAGTCGGCATCCGTGCCAAA	0.433000													20	56					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145770733	145770733	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145770733G>A	ENST00000276826.5	-	5	2622	c.2421C>T	c.(2419-2421)ctC>ctT	p.L807L	ARHGAP39_ENST00000528810.1_5'UTR|ARHGAP39_ENST00000377307.2_Silent_p.L807L|ARHGAP39_ENST00000540274.1_Silent_p.L807L			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	807	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						AGATGGCCATGAGCTCCCAGC	0.637000													9	45					0	0	1	0	0
EHD1	10938	broad.mit.edu	37	11	64627777	64627777	+	Silent	SNP	G	G	A	rs148805183		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64627777G>A	ENST00000320631.3	-	3	788	c.534C>T	c.(532-534)ttC>ttT	p.F178F	EHD1_ENST00000359393.2_Silent_p.F178F	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	178					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						CACGCTCCGCGAACCACTCCA	0.587000													19	34					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49228277	49228277	+	Silent	SNP	G	G	A	rs143841455		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49228277G>A	ENST00000308025.3	-	12	1465	c.1386C>T	c.(1384-1386)atC>atT	p.I462I		NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	462	Helicase ATP-binding.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						CTGACTCTTCGATCCTGTGGT	0.527000													34	53					0	0	1	0	0
SPP1	6696	broad.mit.edu	37	4	88903860	88903860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:88903860G>A	ENST00000237623.7	+	6	863	c.715G>A	c.(715-717)Gag>Aag	p.E239K	SPP1_ENST00000509659.1_3'UTR|SPP1_ENST00000360804.4_Missense_Mutation_p.E226K|SPP1_ENST00000395080.3_Missense_Mutation_p.E253K	NM_000582.2	NP_000573.1	P10451	OSTP_HUMAN	secreted phosphoprotein 1	253					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(1)	13		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		AGCCAATGATGAGAGCAATGA	0.468000													31	102					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13395998	13395998	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13395998G>T	ENST00000360228.5	-	21	3575	c.3576C>A	c.(3574-3576)gaC>gaA	p.D1192E	CACNA1A_ENST00000573710.2_Missense_Mutation_p.D1193E	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1193					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TTGGCAGTGGGTCTGGGTTGG	0.537000													18	59					3.32936e-07	3.33806e-07	1	1	0
CR1	1378	broad.mit.edu	37	1	207758014	207758014	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207758014C>T	ENST00000367049.4	+	33	5323	c.5323C>T	c.(5323-5325)Cca>Tca	p.P1775S	CR1_ENST00000367052.1_Missense_Mutation_p.P1325S|CR1_ENST00000367051.1_Missense_Mutation_p.P1325S|CR1_ENST00000400960.2_Missense_Mutation_p.P1325S|RP11-78B10.2_ENST00000596003.1_RNA|RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367053.1_Missense_Mutation_p.P1325S	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1325	Sushi 28.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TCCAAATCCTCCAGCTATCCT	0.388000													31	117					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274034	10274034	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10274034G>A	ENST00000396573.2	-	3	544	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	GRIN2A_ENST00000404927.2_Missense_Mutation_p.P79S|GRIN2A_ENST00000562109.1_Missense_Mutation_p.P79S|GRIN2A_ENST00000330684.3_Missense_Mutation_p.P79S|GRIN2A_ENST00000396575.2_Missense_Mutation_p.P79S	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	79					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGCTCTTGGGGTCGGTGCGG	0.662000													26	109					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47913525	47913525	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:47913525G>A	ENST00000426837.2	-	13	5910	c.5823C>T	c.(5821-5823)gcC>gcT	p.A1941A	MAP4_ENST00000383737.4_Silent_p.A524A|MAP4_ENST00000395734.3_Silent_p.A796A|MAP4_ENST00000360240.6_Silent_p.A796A|MAP4_ENST00000462206.1_5'UTR|MAP4_ENST00000420772.2_Silent_p.A547A|MAP4_ENST00000264724.11_Silent_p.A531A|MAP4_ENST00000441748.2_5'UTR			P27816	MAP4_HUMAN	microtubule-associated protein 4	796					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CAGATCTGGAGGCTGGGGCAG	0.577000													71	205					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42439523	42439523	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42439523C>T	ENST00000397272.3	-	13	1315	c.1224G>A	c.(1222-1224)agG>agA	p.R408R	PLA2G4F_ENST00000382396.4_Silent_p.R406R	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	406	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		AGGCTGGGTCCCTGTAGAGTG	0.632000													17	35					0	0	1	0	0
FAM178A	55719	broad.mit.edu	37	10	102676652	102676652	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:102676652C>T	ENST00000238961.3	+	3	658	c.510C>T	c.(508-510)tcC>tcT	p.S170S	FAM178A_ENST00000370271.3_Silent_p.S170S|FAM178A_ENST00000370269.3_Silent_p.S170S	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	170																	AACATCGATCCCCAGAGAGAA	0.388000													22	53					0	0	1	0	0
DCN	1634	broad.mit.edu	37	12	91539941	91539941	+	Missense_Mutation	SNP	G	G	A	rs138244851		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91539941G>A	ENST00000052754.5	-	8	1475	c.974C>T	c.(973-975)tCg>tTg	p.S325L	DCN_ENST00000420120.2_Missense_Mutation_p.S216L|DCN_ENST00000425043.1_Missense_Mutation_p.S178L|DCN_ENST00000228329.5_Missense_Mutation_p.S216L|DCN_ENST00000547568.2_Missense_Mutation_p.S178L|DCN_ENST00000393155.1_Missense_Mutation_p.S325L|DCN_ENST00000552962.1_Missense_Mutation_p.S325L|DCN_ENST00000441303.2_Missense_Mutation_p.S138L|DCN_ENST00000303320.3_Missense_Mutation_p.S138L	NM_001920.3	NP_001911.1	P07585	PGS2_HUMAN	decorin	325					organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						ACTCACACCCGAATAAGAAGC	0.463000													46	89					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156642565	156642565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156642565G>A	ENST00000368223.3	-	4	1547	c.1415C>T	c.(1414-1416)cCt>cTt	p.P472L		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	472	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGAGTGGTCAGGGCTGAGGGG	0.612000													20	180					0	0	1	0	0
ZNF80	7634	broad.mit.edu	37	3	113955468	113955468	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113955468G>A	ENST00000482457.2	-	1	957	c.454C>T	c.(454-456)Cgt>Tgt	p.R152C		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	152						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				TGGGTCACACGATGCTGGATG	0.488000													25	84					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145770958	145770958	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145770958G>A	ENST00000276826.5	-	5	2397	c.2196C>T	c.(2194-2196)atC>atT	p.I732I	ARHGAP39_ENST00000528810.1_5'UTR|ARHGAP39_ENST00000377307.2_Silent_p.I732I|ARHGAP39_ENST00000540274.1_Silent_p.I732I			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	732	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CGCTTGTCACGATCATGGGCT	0.612000													13	41					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93839179	93839179	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93839179G>A	ENST00000315765.9	+	17	2936	c.2928G>A	c.(2926-2928)ggG>ggA	p.G976G		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	976	Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AGATTTTTGGGAATCTCCATG	0.333000													15	37					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127549481	127549481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127549481G>A	ENST00000373580.3	+	2	318	c.318G>A	c.(316-318)atG>atA	p.M106I		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	106										endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						AGTGGAAGATGGAGAAACTCA	0.587000													22	46					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39202753	39202753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:39202753C>T	ENST00000351578.6	-	2	500	c.310G>A	c.(310-312)Gag>Aag	p.E104K	FYB_ENST00000515010.1_Missense_Mutation_p.E104K|FYB_ENST00000505428.1_Missense_Mutation_p.E104K|FYB_ENST00000540520.1_Missense_Mutation_p.E114K|FYB_ENST00000512982.1_Missense_Mutation_p.E104K	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	104					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			ACTTTCGCCTCGGGGTCTCTG	0.542000													14	35					0	0	1	0	0
GK5	256356	broad.mit.edu	37	3	141944198	141944198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141944198G>A	ENST00000392993.2	-	1	251	c.100C>T	c.(100-102)Cac>Tac	p.H34Y	GK5_ENST00000466685.3_5'UTR|GK5_ENST00000544571.1_Missense_Mutation_p.H34Y	NM_001039547.2	NP_001034636.1	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	34					glycerol metabolic process		ATP binding|glycerol kinase activity			kidney(1)|large_intestine(1)|lung(7)|urinary_tract(1)	10						TCATAGACGTGGCAGCGGATC	0.701000													5	6					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145111880	145111880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145111880C>T	ENST00000426825.1	-	12	1758	c.1677G>A	c.(1675-1677)gtG>gtA	p.V559V	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	559							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GCAGAGCATCCACACACTGCT	0.652000													3	7					0	0	1	0	0
MRPL9	65005	broad.mit.edu	37	1	151734888	151734888	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151734888G>A	ENST00000368830.3	-	3	483	c.399C>T	c.(397-399)tcC>tcT	p.S133S	MRPL9_ENST00000467306.1_5'UTR|MRPL9_ENST00000368829.3_Silent_p.S133S	NM_031420.2	NP_113608.1	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9	133					translation	mitochondrial ribosome	structural constituent of ribosome			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGTTTTCAGGGGATGCATATA	0.468000													19	147					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92401568	92401568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:92401568G>A	ENST00000276609.3	+	16	1917	c.1678G>A	c.(1678-1680)Gaa>Aaa	p.E560K	SLC26A7_ENST00000523719.1_Missense_Mutation_p.E560K|SLC26A7_ENST00000309536.2_Missense_Mutation_p.E560K|SLC26A7_ENST00000520249.1_3'UTR	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	560	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TCCTACAGAAGAAGCTTCACA	0.438000													86	173					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57428860	57428860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57428860G>A	ENST00000306120.3	+	1	350	c.350G>A	c.(349-351)aGg>aAg	p.R117K	GNAS_ENST00000371100.4_Silent_p.Q180Q|GNAS_ENST00000371075.3_Intron|GNAS_ENST00000371098.2_Intron|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371099.2_Silent_p.Q180Q|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000371102.4_Silent_p.Q180Q|GNAS_ENST00000603534.1_Intron			P63092	GNAS2_HUMAN	GNAS complex locus	292					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TTCTCTTACAGGTCCCAGACC	0.632000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			8	13					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43250678	43250678	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43250678G>A	ENST00000259750.4	+	14	2283	c.2200G>A	c.(2200-2202)Gaa>Aaa	p.E734K		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	734	Glu-rich.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TGGGAaggaggaagaggagga	0.577000													22	31					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20073517	20073517	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20073517C>T	ENST00000351989.3	+	2	460	c.31C>T	c.(31-33)Ccg>Tcg	p.P11S	DGCR8_ENST00000383024.2_Missense_Mutation_p.P11S|DGCR8_ENST00000407755.1_Missense_Mutation_p.P11S	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	11	Necessary for interaction with NCL.|Necessary for nuclear localization and retention.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					CTCTCCGCTCCCGTGTGGGCC	0.557000													60	112					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27517295	27517295	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27517295G>T	ENST00000356183.4	-	10	1710	c.1695C>A	c.(1693-1695)tcC>tcA	p.S565S	GTF3C1_ENST00000561623.1_Silent_p.S565S	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	565						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGGAGACAAAGGACACGTTGG	0.587000													50	82					1.67211e-32	1.68389e-32	1	1	0
TPRX1	284355	broad.mit.edu	37	19	48305051	48305051	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48305051C>T	ENST00000535759.1	-	4	1507	c.1508G>A	c.(1507-1509)aGg>aAg	p.R503K	TPRX1_ENST00000543508.1_Missense_Mutation_p.R396K|TPRX1_ENST00000322175.3_Missense_Mutation_p.R406K			Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox 1	406						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|skin(1)	18		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		CAGTAATAACCTGGGGCCTGA	0.517000													9	104					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150877775	150877775	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:150877775C>T	ENST00000474524.1	+	7	1032	c.994C>T	c.(994-996)Ccc>Tcc	p.P332S	MED12L_ENST00000422248.2_Missense_Mutation_p.P332S|MED12L_ENST00000309237.4_Missense_Mutation_p.P332S|MED12L_ENST00000273432.4_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	332					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TATCGGGGCCCCCAGCCCTGG	0.607000													25	213					0	0	1	0	0
BBS12	166379	broad.mit.edu	37	4	123664511	123664511	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123664511C>T	ENST00000542236.1	+	3	1845	c.1464C>T	c.(1462-1464)atC>atT	p.I488I	BBS12_ENST00000314218.3_Silent_p.I488I	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	488					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						ACAACAGAATCGCAATCTTAT	0.438000									Bardet-Biedl syndrome				15	88					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100147828	100147828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:100147828C>T	ENST00000231461.5	-	5	1113	c.803G>A	c.(802-804)tGg>tAg	p.W268*		NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	268					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		GTTGGTCAGCCAGTAACTGGA	0.363000													19	64					0	0	1	0	0
TMC8	147138	broad.mit.edu	37	17	76128477	76128477	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76128477C>T	ENST00000318430.5	+	4	710	c.336C>T	c.(334-336)ttC>ttT	p.F112F	TMC6_ENST00000322914.3_5'UTR|TMC8_ENST00000589691.1_5'UTR	NM_152468.4	NP_689681.2	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	112						endoplasmic reticulum membrane|integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ACTTCACCTTCCTCCGCTTCC	0.682000													7	18					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135431686	135431686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135431686C>T	ENST00000394143.1	+	6	6112	c.5821C>T	c.(5821-5823)Cct>Tct	p.P1941S	GPR112_ENST00000370652.1_Missense_Mutation_p.P1941S|GPR112_ENST00000287534.4_Missense_Mutation_p.P1878S|GPR112_ENST00000394141.1_Missense_Mutation_p.P1736S|GPR112_ENST00000412101.1_Missense_Mutation_p.P1736S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1941					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GTCATCAATTCCTATGTCAGG	0.433000													37	38					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25294372	25294372	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25294372G>A	ENST00000400358.4	+	19	2513	c.2456G>A	c.(2455-2457)aGc>aAc	p.S819N	SGSM1_ENST00000400359.4_Missense_Mutation_p.S874N	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	874	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						GGCTGGAGGAGCAGCGAGACA	0.592000													11	92					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3081303	3081303	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3081303C>T	ENST00000520002.1	-	29	4990	c.4435G>A	c.(4435-4437)Gac>Aac	p.D1479N	CSMD1_ENST00000542608.1_Missense_Mutation_p.D1478N|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000539096.1_Missense_Mutation_p.D1478N|CSMD1_ENST00000537824.1_Missense_Mutation_p.D1478N|CSMD1_ENST00000602723.1_Missense_Mutation_p.D1479N|CSMD1_ENST00000400186.3_Missense_Mutation_p.D1479N|CSMD1_ENST00000602557.1_Missense_Mutation_p.D1479N			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1479	CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACTCTCCAGTCACATTCCTTC	0.463000													24	60					0	0	1	0	0
KRT19	3880	broad.mit.edu	37	17	39680673	39680673	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39680673G>A	ENST00000361566.3	-	4	840	c.780C>T	c.(778-780)gcC>gcT	p.A260A		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				GGTTCTGCTCGGCCATGACCT	0.602000													10	84					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21229058	21229058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21229058G>A	ENST00000233242.1	-	26	10809	c.10682C>T	c.(10681-10683)tCc>tTc	p.S3561F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3561					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTCCCAGAGGGAATATATGCG	0.458000													22	58					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130831552	130831552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130831552G>A	ENST00000245255.3	+	6	870	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	200					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TTTAACAAATGAACTTCCACC	0.353000													8	66					0	0	1	0	0
PQLC1	80148	broad.mit.edu	37	18	77679198	77679198	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:77679198G>A	ENST00000397778.2	-	5	776	c.594C>T	c.(592-594)tcC>tcT	p.S198S	PQLC1_ENST00000590381.1_Intron|PQLC1_ENST00000409073.1_Silent_p.S115S|PQLC1_ENST00000357575.4_Silent_p.S180S	NM_025078.4	NP_079354.2	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1	198	PQ-loop 2.					integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	9		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		TGCCCTCCGTGGACTGGTGGC	0.612000													12	39					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32913746	32913746	+	Missense_Mutation	SNP	C	C	T	rs80358749		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32913746C>T	ENST00000544455.1	+	11	5481	c.5254C>T	c.(5254-5256)Cat>Tat	p.H1752Y	BRCA2_ENST00000380152.3_Missense_Mutation_p.H1752Y	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1752					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CTATTCCTACCATTCTGATGA	0.308000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			25	53					0	0	1	0	0
COPS7B	64708	broad.mit.edu	37	2	232672238	232672238	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:232672238C>T	ENST00000373608.3	+	8	838	c.731C>T	c.(730-732)cCt>cTt	p.P244L	COPS7B_ENST00000410024.1_Silent_p.S226S|COPS7B_ENST00000350033.3_Silent_p.S226S|COPS7B_ENST00000409295.1_Silent_p.S192S|COPS7B_ENST00000410017.1_Missense_Mutation_p.P249L|COPS7B_ENST00000409091.1_Silent_p.S119S			Q9H9Q2	CSN7B_HUMAN	COP9 signalosome subunit 7B	0					cullin deneddylation	cytoplasm|signalosome				large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)	8		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;1.36e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00136)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CCGCATCCTCCTCGGCTCAGG	0.547000													13	37					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42581868	42581868	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:42581868C>T	ENST00000381668.5	-	11	1193	c.962G>A	c.(961-963)cGa>cAa	p.R321Q	ATP8A1_ENST00000264449.10_Missense_Mutation_p.R321Q	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	321					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity	p.R321Q(1)		NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	AGAATGCCTTCGATTCCAAAT	0.338000													14	52					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62496099	62496099	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62496099G>A	ENST00000225792.5	-	13	2188	c.1787C>T	c.(1786-1788)cCt>cTt	p.P596L	DDX5_ENST00000578804.1_Missense_Mutation_p.P596L|DDX5_ENST00000450599.2_Missense_Mutation_p.P517L	NM_004396.3	NP_004387.1	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 5	596					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	19	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			TGCAGTAGCAGGATATGCATA	0.388000			T	ETV4	prostate								8	66					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93098092	93098092	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:93098092A>G	ENST00000359558.2	-	8	809	c.510T>C	c.(508-510)gcT>gcC	p.A170A	CALCR_ENST00000426151.1_Silent_p.A152A|CALCR_ENST00000360249.4_Silent_p.A152A|CALCR_ENST00000394441.1_Silent_p.A152A|CALCR_ENST00000421592.1_Silent_p.A152A	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	152					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GACCCACAATAGCCAAATAGT	0.343000													15	54					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209790845	209790845	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:209790845G>A	ENST00000391911.1	-	20	3527	c.3138C>T	c.(3136-3138)ctC>ctT	p.L1046L	LAMB3_ENST00000356082.4_Silent_p.L1046L|LAMB3_ENST00000367030.3_Silent_p.L1046L	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1046	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		CTTGGTGGCGGAGCTCCTCCA	0.607000													29	89					0	0	1	0	0
TSPAN32	10077	broad.mit.edu	37	11	2335756	2335756	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:2335756G>A	ENST00000182290.4	+	6	635	c.498G>A	c.(496-498)ggG>ggA	p.G166G	TSPAN32_ENST00000381121.3_Silent_p.G166G|TSPAN32_ENST00000451520.2_Silent_p.G155G|TSPAN32_ENST00000483227.1_3'UTR	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	166					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GCCGTCTGGGGAGCACAGAGG	0.642000													9	13					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35923043	35923043	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35923043C>T	ENST00000490799.1	-	17	2471	c.2118G>A	c.(2116-2118)agG>agA	p.R706R	SLC26A8_ENST00000355574.2_Silent_p.R706R|SLC26A8_ENST00000394602.2_Silent_p.R601R	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	706	Interaction with RACGAP1.|STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						TGAGTGATCTCCTCCCCTGGC	0.517000													29	55					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189022399	189022399	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189022399C>T	ENST00000512729.1	-	3	515	c.141G>A	c.(139-141)gaG>gaA	p.E47E	TRIML2_ENST00000536972.1_Silent_p.E97E|TRIML2_ENST00000326754.3_Silent_p.E47E	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	47							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		AATTTTGTTCCTCTTCCTTCC	0.348000													16	46					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004631	75004631	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:75004631C>T	ENST00000373359.2	-	1	448	c.256G>A	c.(256-258)Gac>Aac	p.D86N		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	86										autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCTAGAGGGTCATGGACCCTG	0.547000													18	24					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227946862	227946862	+	Silent	SNP	C	C	T	rs137880920	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:227946862C>T	ENST00000396625.3	-	23	1872	c.1665G>A	c.(1663-1665)gcG>gcA	p.A555A	COL4A4_ENST00000329662.7_Silent_p.A555A	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	555	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGTCACCCTTCGCCCCTTTGT	0.418000													98	102					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43814503	43814503	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43814503G>A	ENST00000382031.1	+	5	1577	c.1546G>A	c.(1546-1548)Gag>Aag	p.E516K	MAP1A_ENST00000300231.5_Missense_Mutation_p.E278K|MAP1A_ENST00000399453.1_Missense_Mutation_p.E278K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	278	9 X 3 AA repeats of K-K-[DE].					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CAAGATCTTGGAGGGCCTAGA	0.547000													14	61					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19468081	19468081	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19468081C>T	ENST00000219821.5	+	1	310	c.53C>T	c.(52-54)tCc>tTc	p.S18F	TMC5_ENST00000542583.2_Intron|TMC5_ENST00000564959.1_Intron|TMC5_ENST00000561503.1_Intron|TMC5_ENST00000396229.2_Intron|TMC5_ENST00000541464.1_Intron|TMC5_ENST00000381414.4_Intron	NM_024780.4	NP_079056.2	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	0						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GAGAATGTTTCCTCTGGGGTC	0.468000													29	56					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772917	140772917	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140772917C>T	ENST00000398604.2	+	1	537	c.537C>T	c.(535-537)tcC>tcT	p.S179S	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACTTCTCCCTGGACGTGC	0.607000													26	71					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10387188	10387188	+	Silent	SNP	G	G	A	rs111706887		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10387188G>A	ENST00000397077.1	-	17	3023	c.2448C>T	c.(2446-2448)atC>atT	p.I816I	ATP2B2_ENST00000352432.4_Silent_p.I861I|ATP2B2_ENST00000343816.4_Silent_p.I847I|ATP2B2_ENST00000383800.4_Silent_p.I816I|ATP2B2_ENST00000360273.2_Silent_p.I861I			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	861					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CTGCCTTGACGATGCTGCTGA	0.577000													27	60					0	0	1	0	0
EXOSC2	23404	broad.mit.edu	37	9	133576301	133576301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133576301G>A	ENST00000372358.5	+	6	545	c.474G>A	c.(472-474)acG>acA	p.T158T	EXOSC2_ENST00000372351.3_Silent_p.T128T|EXOSC2_ENST00000467138.1_3'UTR|EXOSC2_ENST00000372352.3_Silent_p.T158T|EXOSC2_ENST00000546165.1_Intron			Q13868	EXOS2_HUMAN	exosome component 2	158	S1 motif.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|positive regulation of cell growth|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|7S RNA binding|protein binding			breast(1)|endometrium(1)|large_intestine(3)|ovary(1)	6		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(13;0.0588)		OV - Ovarian serous cystadenocarcinoma(145;0.000324)		CTTTGCACACGAGGAGCCTGA	0.502000											OREG0019548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	56					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39064597	39064597	+	Silent	SNP	G	G	A	rs138598029	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:39064597G>A	ENST00000331366.5	-	19	1536	c.1440C>T	c.(1438-1440)gtC>gtT	p.V480V	CPNE8_ENST00000538596.2_Silent_p.V149V|CPNE8_ENST00000546603.1_5'UTR|CPNE8_ENST00000360449.3_Silent_p.V468V	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	480	VWFA.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CATCCAATTCGACCATTGCTT	0.338000													17	45					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3850757	3850757	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3850757G>A	ENST00000309890.7	-	8	1173	c.1023C>T	c.(1021-1023)acC>acT	p.T341T	ATP2A3_ENST00000359983.3_Silent_p.T341T|ATP2A3_ENST00000352011.3_Silent_p.T341T|ATP2A3_ENST00000397041.3_Silent_p.T341T|ATP2A3_ENST00000397035.3_Silent_p.T341T|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397043.3_Silent_p.T341T	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	341					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		TGCAGCCCAGGGTCTCCACGG	0.647000													33	43					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165947774	165947774	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165947774C>T	ENST00000360093.3	-	28	5380	c.4889G>A	c.(4888-4890)cGa>cAa	p.R1630Q	SCN3A_ENST00000409101.3_Missense_Mutation_p.R1581Q|AC013463.2_ENST00000431341.1_RNA|SCN3A_ENST00000283254.7_Missense_Mutation_p.R1630Q|SCN3A_ENST00000540861.1_Missense_Mutation_p.R113Q	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1630						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ACGTAGGATTCGGCCAATCCT	0.478000													52	113					0	0	1	0	0
ZNF702P	79986	broad.mit.edu	37	19	53473805	53473805	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:53473805G>A	ENST00000600068.1	-	0	489				ZNF702P_ENST00000270443.4_RNA																							AGATGTGAATGAAAGCTTGAT	0.388000													38	104					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26822398	26822398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26822398G>A	ENST00000376236.4	+	9	1299	c.844G>A	c.(844-846)Gaa>Aaa	p.E282K		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	282					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						AGGAAAAAAAGAAAGCAAGGA	0.343000													9	47					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37319369	37319369	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37319369C>T	ENST00000262825.5	+	3	377	c.160C>T	c.(160-162)Cag>Tag	p.Q54*	CSF2RB_ENST00000406230.1_Nonsense_Mutation_p.Q54*|CSF2RB_ENST00000403662.3_Nonsense_Mutation_p.Q54*	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	54					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CCAGGATGCCCAGCGGCTCGT	0.637000													11	41					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77677753	77677753	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77677753C>T	ENST00000296043.6	+	8	5814	c.4861C>T	c.(4861-4863)Cac>Tac	p.H1621Y		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1621					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			CATGAGCGTTCACGCCCAACT	0.537000													34	66					0	0	1	0	0
HOXA9	3205	broad.mit.edu	37	7	27204563	27204563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:27204563C>T	ENST00000343483.6	-	1	586	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	RP1-170O19.20_ENST00000465941.1_Intron|HOXA9_ENST00000497089.1_Intron|RP1-170O19.20_ENST00000470747.4_Missense_Mutation_p.E12K|HOXA9_ENST00000396345.1_3'UTR	NM_152739.3	NP_689952.1	P31269	HXA9_HUMAN	homeobox A9	172							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|lung(5)|prostate(1)	8						AAGGCGCCTTCGCTGGGTTGT	0.552000			T	"""NUP98, MSI2"""	AML*								18	57					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541451	40541451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40541451G>A	ENST00000434248.1	-	5	1380	c.1315C>T	c.(1315-1317)Cat>Tat	p.H439Y	ZNF780B_ENST00000221355.6_Missense_Mutation_p.H291Y	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	439					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCATTGGAATGAATTTTTTGA	0.378000													42	210					0	0	1	0	0
OR6C4	341418	broad.mit.edu	37	12	55945863	55945863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55945863C>T	ENST00000394256.2	+	1	881	c.853C>T	c.(853-855)Ccc>Tcc	p.P285S	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						CTTACTGAATCCCTTCATATA	0.348000													22	64					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62125259	62125259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62125259G>A	ENST00000433197.2	-	19	2583	c.2488C>T	c.(2488-2490)Ccg>Tcg	p.P830S		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	830	Protein kinase.		P -> L (in an ovarian serous carcinoma sample; somatic mutation).		activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						CAGAAGAACGGGTGTTTGAGC	0.438000													17	50					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77662013	77662013	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77662013G>A	ENST00000296043.6	+	5	3640	c.2687G>A	c.(2686-2688)aGc>aAc	p.S896N		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	896					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			CAGCTCTCCAGCGAGCCAGAG	0.711000													10	19					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95338948	95338948	+	Silent	SNP	C	C	T	rs140807207	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:95338948C>T	ENST00000371483.4	+	3	785	c.729C>T	c.(727-729)gtC>gtT	p.V243V	FFAR4_ENST00000604414.1_Intron|FFAR4_ENST00000371481.4_Intron	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		CAAGAGCTGTCGTGACTCACA	0.493000													22	64					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810494	31810494	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:31810494G>A	ENST00000446923.2	+	7	2574	c.2183G>A	c.(2182-2184)gGa>gAa	p.G728E	ZEB1_ENST00000361642.5_Missense_Mutation_p.G745E|ZEB1_ENST00000542815.3_Missense_Mutation_p.G677E|ZEB1_ENST00000320985.10_Missense_Mutation_p.G744E|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000560721.2_Missense_Mutation_p.G724E	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	744					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAGCAACAGGGAGAATTATTA	0.428000													22	93					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170964567	170964567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:170964567C>T	ENST00000367759.4	+	13	1386	c.1232C>T	c.(1231-1233)tCc>tTc	p.S411F	MROH9_ENST00000367758.3_Missense_Mutation_p.S411F	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		CCTCTTGGTTCCTACAGGAAA	0.478000													41	108					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48390061	48390061	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48390061C>T	ENST00000224600.4	-	1	930	c.817G>A	c.(817-819)Gag>Aag	p.E273K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	273	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	AAGTCAGACTCGCCTATCCTC	0.677000													10	25					0	0	1	0	0
PNPLA8	50640	broad.mit.edu	37	7	108138000	108138000	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:108138000G>A	ENST00000426128.2	-	5	1505	c.1380C>T	c.(1378-1380)acC>acT	p.T460T	PNPLA8_ENST00000257694.8_Silent_p.T460T|PNPLA8_ENST00000388728.5_Silent_p.T460T|PNPLA8_ENST00000483879.1_5'UTR|PNPLA8_ENST00000422087.1_Silent_p.T460T|PNPLA8_ENST00000436062.1_Silent_p.T460T|PNPLA8_ENST00000453144.1_Silent_p.T360T	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	460	Patatin.				fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						ATTTTCGTAGGGTCTGGAGAG	0.343000													24	46					0	0	1	0	0
HCN4	10021	broad.mit.edu	37	15	73635884	73635884	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:73635884G>A	ENST00000261917.3	-	2	2044	c.1051C>T	c.(1051-1053)Ccc>Tcc	p.P351S		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	351					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		TAGTCCACGGGGATGGAGGAA	0.527000													12	72					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16902777	16902777	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16902777G>A	ENST00000430580.2	-	19	2991	c.2104C>T	c.(2104-2106)Caa>Taa	p.Q702*	NBPF1_ENST00000432949.1_Nonsense_Mutation_p.Q160*|NBPF1_ENST00000287968.8_Nonsense_Mutation_p.Q67*	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	702						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CTGAGCTTTTGGACAAGGTGC	0.562000													31	680					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100847882	100847882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100847882C>T	ENST00000554175.1	+	2	800	c.621C>T	c.(619-621)gcC>gcT	p.207_207insA	WDR25_ENST00000335290.6_Silent_p.A207A|WDR25_ENST00000554998.1_Silent_p.A207A|WDR25_ENST00000402312.3_Silent_p.A207A			Q64LD2	WDR25_HUMAN	WD repeat domain 25											central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				CAGGGCGTGCCCCAGCCCCTC	0.547000													40	100					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351410	89351410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89351410G>A	ENST00000301030.4	-	9	2000	c.1540C>T	c.(1540-1542)Ctg>Ttg	p.L514L	ANKRD11_ENST00000378330.2_Silent_p.L514L	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	514	Ser-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GAGCTGAACAGGGAGGGGTCC	0.652000													19	47					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7727852	7727852	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7727852G>A	ENST00000283147.6	+	1	823	c.664_splice	c.e1+1	p.V222_splice		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	222					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					TGTGAACCTGGGTAAGGATTT	0.647000													7	25					0	0	1	0	0
RAB38	23682	broad.mit.edu	37	11	87847224	87847224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:87847224G>A	ENST00000243662.6	-	3	650	c.568C>T	c.(568-570)Ccg>Tcg	p.P190S	RP11-164N3.3_ENST00000528458.1_RNA	NM_022337.2	NP_071732.1	P57729	RAB38_HUMAN	RAB38, member RAS oncogene family	190					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ACGACGTCCGGCTCAATAGAC	0.468000													41	142					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145379722	145379722	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145379722G>A	ENST00000511217.1	+	2	532	c.480G>A	c.(478-480)gaG>gaA	p.E160E	SH3RF2_ENST00000359120.4_Silent_p.E160E			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	160	SH3 1.						ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCTTGATGAGAATTGGTACC	0.557000													21	57					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123302227	123302227	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123302227G>A	ENST00000296513.2	+	4	438	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K	ADAD1_ENST00000492454.1_3'UTR|ADAD1_ENST00000388725.2_Missense_Mutation_p.E67K|ADAD1_ENST00000388724.2_Missense_Mutation_p.E85K	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	85					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding	p.E85K(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						AATACCTAAGGAATTTATAAT	0.368000													33	84					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19632552	19632552	+	Missense_Mutation	SNP	G	G	A	rs79772073		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19632552G>A	ENST00000235835.3	-	6	899	c.878C>T	c.(877-879)tCg>tTg	p.S293L		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	293					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GAGGGCAGCCGAGGTCACACT	0.632000													23	74					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18691100	18691100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18691100C>T	ENST00000433979.1	+	24	3327	c.3211C>T	c.(3211-3213)Cct>Tct	p.P1071S	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.P1071S|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.P1112S	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1071	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				GGACCGAGCTCCTTTCATTTT	0.368000													27	51					0	0	1	0	0
REN	5972	broad.mit.edu	37	1	204124271	204124271	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204124271G>A	ENST00000367195.2	-	9	1128	c.1085C>T	c.(1084-1086)gCc>gTc	p.A362V	REN_ENST00000272190.8_Missense_Mutation_p.A365V			P00797	RENI_HUMAN	renin	365					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGCGTGGATGGCCAGTGTGCA	0.552000													28	57					0	0	1	0	0
SLC1A7	6512	broad.mit.edu	37	1	53580495	53580495	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53580495C>T	ENST00000371494.4	-	3	493	c.366G>A	c.(364-366)aaG>aaA	p.K122K	SLC1A7_ENST00000371491.4_Silent_p.K122K|RP11-334A14.8_ENST00000439621.1_RNA	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	122						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	CCGTGGTCTCCTTCTGGGCCG	0.612000													11	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179539769	179539769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179539769C>T	ENST00000589042.1	-	150	34833	c.34609G>A	c.(34609-34611)Gaa>Aaa	p.E11537K	TTN_ENST00000342992.6_Missense_Mutation_p.E10236K|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E11163K|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11300	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTACCTTCAACTGGTAGA	0.333000													12	27					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101715887	101715887	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:101715887G>A	ENST00000342239.3	-	4	1435	c.1344C>T	c.(1342-1344)ccC>ccT	p.P448P	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Silent_p.P448P			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	448					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		TTGCTTCTAGGGGAAGAAGGT	0.502000													38	146					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36893237	36893237	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36893237G>A	ENST00000301807.6	-	14	4975	c.3078C>T	c.(3076-3078)ctC>ctT	p.L1026L	TRANK1_ENST00000429976.2_Silent_p.L1576L|TRANK1_ENST00000428977.2_Silent_p.L1026L	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1576					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGTTGTAAAGGAGGACATCAT	0.383000													6	24					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123022953	123022953	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123022953G>A	ENST00000462833.1	-	13	3732	c.2520C>T	c.(2518-2520)ttC>ttT	p.F840F	ADCY5_ENST00000491190.1_Silent_p.F473F|ADCY5_ENST00000309879.5_Silent_p.F490F	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	840					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		GGGTGATGGTGAACACCCCAA	0.617000													15	54					0	0	1	0	0
TM6SF2	53345	broad.mit.edu	37	19	19375544	19375544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19375544G>A	ENST00000389363.4	-	10	1135	c.1063C>T	c.(1063-1065)Ctt>Ttt	p.L355F	AC138430.4_ENST00000586064.2_RNA	NM_001001524.2	NP_001001524.2	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	355						integral to membrane				breast(2)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14			Epithelial(12;0.0151)			GGCCACTGAAGGCAACGGTAG	0.622000													32	45					0	0	1	0	0
NBR1	4077	broad.mit.edu	37	17	41342735	41342735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:41342735C>T	ENST00000422280.1	+	9	1264	c.805C>T	c.(805-807)Ccg>Tcg	p.P269S	NBR1_ENST00000590996.1_Missense_Mutation_p.P269S|NBR1_ENST00000389312.4_Missense_Mutation_p.P269S|NBR1_ENST00000341165.6_Missense_Mutation_p.P269S|NBR1_ENST00000542611.1_Missense_Mutation_p.P248S|NBR1_ENST00000589872.1_Missense_Mutation_p.P269S	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	269					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		CTCCTCTGAACCGTTCTGTCA	0.478000													15	16					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349594	100349594	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100349594C>T	ENST00000542585.1	+	0	2014				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCACCATTCCCTCAGAAAAAC	0.473000													44	90					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50736487	50736487	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50736487G>A	ENST00000355832.5	-	4	706	c.628C>T	c.(628-630)Cac>Tac	p.H210Y	ERCC6-PGBD3_ENST00000515869.1_Missense_Mutation_p.H210Y|PGBD3_ENST00000603152.1_Missense_Mutation_p.H210Y|ERCC6-PGBD3_ENST00000447839.2_Missense_Mutation_p.H210Y	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	210					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AGACTGGCGTGATCTAGTTCA	0.458000								Direct reversal of damage;Nucleotide excision repair (NER)					24	71					0	0	1	0	0
MRRF	92399	broad.mit.edu	37	9	125042722	125042722	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125042722C>T	ENST00000344641.3	+	3	496	c.184_splice	c.e3-1	p.A62_splice	MRRF_ENST00000373727.1_Splice_Site_p.A62_splice|MRRF_ENST00000373723.4_Splice_Site_p.A62_splice|MRRF_ENST00000373730.3_Splice_Site_p.A62_splice|MRRF_ENST00000394315.3_Splice_Site_p.A62_splice|MRRF_ENST00000297908.3_Intron|MRRF_ENST00000546115.1_Splice_Site_p.A62_splice|MRRF_ENST00000373728.1_Splice_Site_p.A62_splice|MRRF_ENST00000373729.1_Splice_Site_p.A18_splice	NM_138777.3	NP_620132.1	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor	62					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	12						CACTTTTTAGCCAAAGGGAAA	0.383000													18	58					0	0	1	0	0
SSX5	6758	broad.mit.edu	37	X	48047099	48047099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48047099C>T	ENST00000311798.1	-	8	710	c.658G>A	c.(658-660)Gag>Aag	p.E220K	SSX5_ENST00000347757.1_Missense_Mutation_p.E179K|SSX5_ENST00000376923.1_Missense_Mutation_p.E179K	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						TCGCTGATCTCTTCATAAATC	0.483000													119	122					0	0	1	0	0
NMU	10874	broad.mit.edu	37	4	56496595	56496595	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:56496595C>T	ENST00000264218.3	-	2	250	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	NMU_ENST00000505262.1_Missense_Mutation_p.E49K|NMU_ENST00000511469.1_Missense_Mutation_p.E49K|NMU_ENST00000515325.1_5'UTR|NMU_ENST00000507338.1_Missense_Mutation_p.E49K	NM_006681.2	NP_006672.1	P48645	NMU_HUMAN	neuromedin U	49					neuropeptide signaling pathway	extracellular region				lung(3)|ovary(1)|urinary_tract(1)	5	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		AGCTGTTGTTCAGGCTGTAAT	0.294000													8	87					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768165	117768165	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117768165C>T	ENST00000317775.6	-	2	1395	c.710G>A	c.(709-711)gGa>gAa	p.G237E	NOS1_ENST00000344089.3_Missense_Mutation_p.G237E|NOS1_ENST00000338101.4_Missense_Mutation_p.G237E	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	237	PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CACCTGGATTCCCATATCTTT	0.557000													23	81					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159654376	159654376	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159654376C>T	ENST00000297267.9	+	11	3032	c.2832C>T	c.(2830-2832)tcC>tcT	p.S944S	FNDC1_ENST00000340366.6_Silent_p.S881S	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	944						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGTACTCCTCCCTGGCCTCCA	0.617000													9	14					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124437990	124437990	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124437990C>T	ENST00000360013.3	+	60	8761	c.8634C>T	c.(8632-8634)tcC>tcT	p.S2878S	KALRN_ENST00000291478.4_Silent_p.S1181S|KALRN_ENST00000428018.2_Silent_p.S1149S	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2877	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GTGGGGTCTCCCCCTTCTTGG	0.527000													21	35					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87913508	87913508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87913508C>T	ENST00000380079.4	-	2	178	c.77G>A	c.(76-78)gGa>gAa	p.G26E	STEAP4_ENST00000414498.1_Missense_Mutation_p.G26E|AC003991.3_ENST00000434733.1_RNA|AC003991.3_ENST00000447758.1_RNA|STEAP4_ENST00000301959.5_Missense_Mutation_p.G26E|AC003991.3_ENST00000600908.1_RNA|AC003991.3_ENST00000595121.1_RNA	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	26					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					ATCACCAGTTCCAAAAATACA	0.383000													16	78					0	0	1	0	0
CRYBA2	1412	broad.mit.edu	37	2	219856910	219856910	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219856910C>T	ENST00000295728.2	-	2	453	c.217G>A	c.(217-219)Gga>Aga	p.G73R	CRYBA2_ENST00000392096.2_Missense_Mutation_p.G73R	NM_057093.1	NP_476434.1	P53672	CRBA2_HUMAN	crystallin, beta A2	73	Beta/gamma crystallin 'Greek key' 2.						structural constituent of eye lens			endometrium(1)|lung(3)|prostate(1)	5		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGATAGTCTCCCTTCTCCAGA	0.617000													18	38					0	0	1	0	0
C9orf152	401546	broad.mit.edu	37	9	112963511	112963511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112963511C>T	ENST00000400613.4	-	2	1046	c.437G>A	c.(436-438)gGa>gAa	p.G146E	C9orf152_ENST00000473442.1_Intron	NM_001012993.2	NP_001013011.2	Q5JTZ5	CI152_HUMAN	chromosome 9 open reading frame 152	146										NS(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						TTGATCAGATCCCACAAGCTT	0.532000													69	173					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482500	20482500	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20482500C>T	ENST00000573854.1	+	5	816	c.702C>T	c.(700-702)tcC>tcT	p.S234S	ACSM2A_ENST00000575690.1_Silent_p.S234S|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Silent_p.S234S|ACSM2A_ENST00000536134.1_Intron|ACSM2A_ENST00000417235.2_Silent_p.S155S|ACSM2A_ENST00000396104.2_Silent_p.S234S	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	234					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CAGAACATTCCTACTCGAGCC	0.498000													15	79					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142571444	142571444	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142571444C>T	ENST00000359396.3	-	13	1790	c.1545G>A	c.(1543-1545)gaG>gaA	p.E515E		NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	515					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					CCTCGGGGTCCTCTGTCTGGA	0.587000													15	140					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40045876	40045876	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40045876C>T	ENST00000336649.4	+	12	1956	c.1956C>T	c.(1954-1956)atC>atT	p.I652I	CACNA1I_ENST00000404898.1_Silent_p.I611I|CACNA1I_ENST00000402142.3_Silent_p.I646I|CACNA1I_ENST00000401624.1_Silent_p.I646I|CACNA1I_ENST00000400164.3_Silent_p.I611I|CACNA1I_ENST00000407673.1_Silent_p.I611I			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	646					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ACCGGGGCATCATGATGGCCA	0.677000													9	33					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22051671	22051671	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22051671C>T	ENST00000306385.5	+	10	1951	c.1281C>T	c.(1279-1281)ttC>ttT	p.F427F	BMP1_ENST00000354870.5_3'UTR|BMP1_ENST00000397816.3_Silent_p.F427F|BMP1_ENST00000397814.3_Silent_p.F427F|BMP1_ENST00000306349.8_Silent_p.F427F	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	427	CUB 1.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GAAAGGGCTTCTTTGCAGTCT	0.592000													30	47					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228559601	228559601	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228559601C>T	ENST00000570156.2	+	105	24067	c.23993C>T	c.(23992-23994)tCt>tTt	p.S7998F	OBSCN_ENST00000366707.4_Missense_Mutation_p.S4675F|OBSCN_ENST00000422127.1_Missense_Mutation_p.S7041F	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7041					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AAGCAGGGTTCTGCCCCCCAG	0.672000													12	27					0	0	1	0	0
C12orf76	400073	broad.mit.edu	37	12	110495058	110495058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110495058G>A	ENST00000309050.5	-	4	599	c.235C>T	c.(235-237)Cct>Tct	p.P79S	C12orf76_ENST00000548191.1_Intron|C12orf76_ENST00000548936.1_Intron	NM_207435.1	NP_997318.1	Q8N812	CL076_HUMAN	chromosome 12 open reading frame 76	79										endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6						AGCTCTGCAGGGAGGATGTGC	0.502000													16	34					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52367790	52367790	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52367790C>T	ENST00000296585.5	+	18	2401	c.2258C>T	c.(2257-2259)tCt>tTt	p.S753F		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	753					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GTTGTCAACTCTTTGGATTTG	0.453000													19	43					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80044325	80044325	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80044325G>A	ENST00000306749.2	-	22	3755	c.3537C>T	c.(3535-3537)ccC>ccT	p.P1179P		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1179					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	ACAACAGCCGGGGCAGTTCCT	0.677000													17	31					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13363829	13363829	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:13363829G>A	ENST00000254508.5	-	35	4861	c.4779C>T	c.(4777-4779)acC>acT	p.T1593T		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1593					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TCTGGGTGGGGGTGCACTCGC	0.622000													31	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179552902	179552902	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179552902G>A	ENST00000589042.1	-	127	32471	c.32247C>T	c.(32245-32247)tcC>tcT	p.S10749S	TTN_ENST00000342992.6_Silent_p.S9505S|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.S10432S|TTN-AS1_ENST00000431752.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10432	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAACTGAAATGGACACACCTT	0.393000													54	139					0	0	1	0	0
ADAP1	11033	broad.mit.edu	37	7	959657	959657	+	Silent	SNP	C	C	T	rs149827249		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:959657C>T	ENST00000265846.5	-	4	555	c.336G>A	c.(334-336)aaG>aaA	p.K112K	ADAP1_ENST00000463358.1_5'UTR|ADAP1_ENST00000449296.2_Silent_p.K40K|ADAP1_ENST00000539900.1_Silent_p.K123K	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	112	Arf-GAP.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						GTCGCTCGTACTTGGCCCGGA	0.682000													9	27					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48729266	48729266	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48729266C>T	ENST00000316623.5	-	53	6843	c.6388G>A	c.(6388-6390)Gaa>Aaa	p.E2130K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2130	EGF-like 36; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TCTTTGCATTCGTCCATATCT	0.343000													16	53					0	0	1	0	0
KPNA6	23633	broad.mit.edu	37	1	32635512	32635512	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32635512C>T	ENST00000373625.3	+	13	1367	c.1274C>T	c.(1273-1275)cCc>cTc	p.P425L	KPNA6_ENST00000537234.1_Missense_Mutation_p.P422L|KPNA6_ENST00000545542.1_Missense_Mutation_p.P430L	NM_012316.4	NP_036448.1	O60684	IMA7_HUMAN	karyopherin alpha 6 (importin alpha 7)	425					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding			large_intestine(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TGCATCAAACCCCTATGTGAC	0.542000													50	144					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4228965	4228965	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:4228965C>T	ENST00000379453.4	-	1	756	c.640G>A	c.(640-642)Gcc>Acc	p.A214T		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	214					cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	AGGATGGCGGCCGCCTTGCGC	0.687000													4	6					0	0	1	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919877	142919877	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142919877G>A	ENST00000408947.3	+	1	748	c.706G>A	c.(706-708)Gac>Aac	p.D236N		NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	236					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					AGGGTCCAGGGACCCCAGCAT	0.507000													12	167					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354001	57354001	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57354001C>T	ENST00000314922.3	-	2	710	c.634G>A	c.(634-636)Ggc>Agc	p.G212S	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.G212S	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	212					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CTCATGAAGCCCCCATATCGC	0.537000													57	89					0	0	1	0	0
YEATS4	8089	broad.mit.edu	37	12	69756579	69756579	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:69756579C>T	ENST00000247843.2	+	2	333	c.63C>T	c.(61-63)atC>atT	p.I21I	YEATS4_ENST00000548020.1_Silent_p.I21I	NM_006530.2	NP_006521.1	O95619	YETS4_HUMAN	YEATS domain containing 4	21					histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)	5	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			GTGTTACTATCGTTAAACCAA	0.308000													21	60					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233752796	233752796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:233752796C>T	ENST00000264051.3	-	9	1572	c.1294G>A	c.(1294-1296)Gag>Aag	p.E432K	NGEF_ENST00000539537.1_Missense_Mutation_p.E155K|NGEF_ENST00000373552.4_Missense_Mutation_p.E340K	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	432	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TCAGACCTCTCTTCTACCCTC	0.488000													29	62					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157475585	157475585	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157475585G>A	ENST00000389413.3	-	12	1849	c.1746C>T	c.(1744-1746)gaC>gaT	p.D582D	PTPRN2_ENST00000389416.4_Silent_p.D594D|PTPRN2_ENST00000404321.2_Silent_p.D634D|PTPRN2_ENST00000389418.4_Silent_p.D611D|PTPRN2_ENST00000409483.1_Silent_p.D573D	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	611						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACTTGGTGGAGTCTTCTTGCT	0.572000													18	33					0	0	1	0	0
CARD16	114769	broad.mit.edu	37	11	104912255	104912255	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:104912255G>A	ENST00000375706.2	-	3	483	c.466C>T	c.(466-468)Ctt>Ttt	p.L156F	CASP1_ENST00000415981.2_Intron|CASP1_ENST00000593315.1_Intron|CASP1_ENST00000594519.1_Intron|CARD16_ENST00000375704.3_3'UTR|CASP1_ENST00000598974.1_Intron	NM_001017534.1	NP_001017534.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						TTGGTTCTAAGAAAAAGCCAC	0.383000													46	88					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74289945	74289945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74289945G>A	ENST00000262765.5	-	4	544	c.365C>T	c.(364-366)tCt>tTt	p.S122F		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	122							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						TGTGCCACCAGATCCTGATGC	0.577000													5	89					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99932090	99932090	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:99932090G>A	ENST00000524871.1	+	10	1417	c.1127G>A	c.(1126-1128)gGa>gAa	p.G376E	CNTN5_ENST00000279463.3_Missense_Mutation_p.G376E|CNTN5_ENST00000528682.1_Missense_Mutation_p.G376E|CNTN5_ENST00000527185.1_Missense_Mutation_p.G376E|CNTN5_ENST00000418526.2_Missense_Mutation_p.G302E	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	376	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AACTCACGTGGAAAAAATTCC	0.423000													31	50					0	0	1	0	0
ACSL3	2181	broad.mit.edu	37	2	223806250	223806250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:223806250C>T	ENST00000357430.3	+	17	2572	c.2041C>T	c.(2041-2043)Cgt>Tgt	p.R681C	ACSL3_ENST00000392066.3_Missense_Mutation_p.R681C	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	681					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding	p.R681C(5)		cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	AGTAAAAATTCGTTTGAGTCC	0.378000			T	ETV1	prostate								32	55					0	0	1	0	0
KBTBD13	390594	broad.mit.edu	37	15	65370117	65370117	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65370117G>A	ENST00000432196.2	+	1	964	c.964G>A	c.(964-966)Gag>Aag	p.E322K		NM_001101362.2	NP_001094832.1	C9JR72	KBTBD_HUMAN	kelch repeat and BTB (POZ) domain containing 13	322						cytoplasm				lung(1)|prostate(1)|skin(1)	3						CGCCGTGGTGGAGTACGCAGT	0.731000													8	10					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68405072	68405072	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68405072C>T	ENST00000219334.5	-	3	1616	c.1013G>A	c.(1012-1014)aGg>aAg	p.R338K	SMPD3_ENST00000563226.1_Missense_Mutation_p.R338K|SMPD3_ENST00000568373.1_Missense_Mutation_p.R338K	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	338					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	GGGGTGCCGCCTCCTGCGTGC	0.662000													16	31					0	0	1	0	0
ICAM3	3385	broad.mit.edu	37	19	10449579	10449579	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10449579G>A	ENST00000160262.5	-	2	330	c.122C>T	c.(121-123)cCt>cTt	p.P41L	ICAM3_ENST00000589261.1_5'UTR	NM_002162.3	NP_002153.2	P32942	ICAM3_HUMAN	intercellular adhesion molecule 3	41					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	13			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			AGAGAGCACAGGGTTCTGGGG	0.552000													19	63					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063345	9063345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9063345G>A	ENST00000397910.4	-	3	24304	c.24101C>T	c.(24100-24102)tCa>tTa	p.S8034L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8036	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATTTCAACTGAGGTGCTGCT	0.468000													38	86					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35786728	35786728	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35786728G>A	ENST00000361922.4	+	4	409	c.259G>A	c.(259-261)Ggc>Agc	p.G87S	MAG_ENST00000392213.3_Missense_Mutation_p.G87S|MAG_ENST00000597035.1_Intron|MAG_ENST00000537831.2_Missense_Mutation_p.G62S	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	87	Ig-like V-type.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GAGCTTCCAGGGCCGCAGCCG	0.632000													58	167					0	0	1	0	0
TEKT1	83659	broad.mit.edu	37	17	6719205	6719205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:6719205C>T	ENST00000338694.2	-	4	562	c.433G>A	c.(433-435)Ggc>Agc	p.G145S	TEKT1_ENST00000535086.1_5'UTR	NM_053285.1	NP_444515.1	Q969V4	TEKT1_HUMAN	tektin 1	145					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20		Myeloproliferative disorder(207;0.0255)				GCCATAATGCCCTGGATGATC	0.557000													26	35					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55956220	55956220	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:55956220C>T	ENST00000263923.4	-	23	3390	c.3095G>A	c.(3094-3096)cGa>cAa	p.R1032Q	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1032	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.R1032Q(2)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GAGGATATTTCGTGCCGCCAG	0.448000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			28	89					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136113	40136113	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:40136113C>T	ENST00000278198.2	-	2	3693	c.1730G>A	c.(1729-1731)gGa>gAa	p.G577E	LRRC4C_ENST00000530763.1_Missense_Mutation_p.G577E|LRRC4C_ENST00000528697.1_Missense_Mutation_p.G577E|LRRC4C_ENST00000527150.1_Missense_Mutation_p.G577E			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	577					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGGTGTGTCTCCCGTAATCTC	0.458000													60	58					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907435	12907435	+	Silent	SNP	C	C	T	rs2076062		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12907435C>T	ENST00000317869.6	-	2	933	c.708G>A	c.(706-708)gtG>gtA	p.V236V		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						ACTCCATCTTCACATGAGTCT	0.478000													15	257					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44477310	44477310	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44477310G>A	ENST00000360584.2	-	2	363	c.172C>T	c.(172-174)Ctc>Ttc	p.L58F	SLC6A9_ENST00000372307.3_Intron|SLC6A9_ENST00000372310.3_Intron|SLC6A9_ENST00000357730.2_Intron|SLC6A9_ENST00000372306.3_Intron|SLC6A9_ENST00000492434.2_Intron|SLC6A9_ENST00000475075.2_Intron|SLC6A9_ENST00000537678.1_Intron	NM_201649.3	NP_964012.2	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	58						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CAGACTTTGAGGACAGACTCT	0.617000													21	53					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11197563	11197563	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:11197563C>T	ENST00000337414.4	-	7	2211	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	ARHGAP6_ENST00000303025.6_Missense_Mutation_p.E244K|ARHGAP6_ENST00000413512.3_Missense_Mutation_p.E256K|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.E479K|ARHGAP6_ENST00000491514.1_5'UTR|ARHGAP6_ENST00000380718.1_Missense_Mutation_p.E447K|ARHGAP6_ENST00000534860.1_Missense_Mutation_p.E272K|ARHGAP6_ENST00000380736.1_Missense_Mutation_p.E244K	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	447	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CGGTCAAATTCCTCACGTAAC	0.517000													16	25					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79363967	79363967	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:79363967C>T	ENST00000444841.1	-	0	371																											TGGTGCCACTCTCTTTAATCA	0.522000													17	31					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50537852	50537852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:50537852C>T	ENST00000444124.2	-	12	1259	c.1059G>A	c.(1057-1059)ctG>ctA	p.L353L	DDC_ENST00000357936.5_Silent_p.L353L|DDC_ENST00000431062.1_Silent_p.L260L|DDC_ENST00000426377.1_Silent_p.L275L	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	353					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	ATCTTCTGCCCAGTGGTATCT	0.418000													32	97					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981739	7981739	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7981739G>A	ENST00000328600.2	-	2	1581	c.1420C>T	c.(1420-1422)Cat>Tat	p.H474Y		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	474	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GACATGGCATGAAAAAAGTCC	0.532000													13	124					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71709035	71709035	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:71709035C>T	ENST00000258104.3	+	3	448	c.171C>T	c.(169-171)atC>atT	p.I57I	DYSF_ENST00000394120.2_Silent_p.I58I|DYSF_ENST00000409744.1_Silent_p.I58I|DYSF_ENST00000410020.3_Silent_p.I58I|DYSF_ENST00000413539.2_Silent_p.I57I|DYSF_ENST00000429174.2_Silent_p.I57I|DYSF_ENST00000409366.1_Silent_p.I58I|DYSF_ENST00000409582.3_Silent_p.I57I|DYSF_ENST00000409762.1_Silent_p.I57I|DYSF_ENST00000409651.1_Silent_p.I58I|DYSF_ENST00000410041.1_Silent_p.I58I	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	57	C2 1.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TCAAGGGCATCCCCCTGGACC	0.537000													11	26					0	0	1	0	0
C1QTNF9B	387911	broad.mit.edu	37	13	24465472	24465472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:24465472C>T	ENST00000382137.3	-	3	1026	c.958G>A	c.(958-960)Gat>Aat	p.D320N	C1QTNF9B_ENST00000556521.1_5'UTR|C1QTNF9B_ENST00000382140.2_Missense_Mutation_p.D320N|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B-AS1_ENST00000382133.4_RNA|C1QTNF9B_ENST00000382145.1_3'UTR	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	320	C1q.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						GTTGTGTCATCGTCCTCATCA	0.517000													26	96					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20761100	20761100	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20761100C>T	ENST00000400451.2	+	5	2291	c.1777C>T	c.(1777-1779)Ctc>Ttc	p.L593F	ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Missense_Mutation_p.L593F|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000405993.1_Missense_Mutation_p.L561F	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	593					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			caaacacctgctcagcacata	0.592000													7	60					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370507	240370507	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240370507G>A	ENST00000319653.9	+	5	2625	c.2395G>A	c.(2395-2397)Gac>Aac	p.D799N		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	799	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AGTCCAGCTCGACAGCCATCA	0.572000													22	74					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160059264	160059264	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:160059264T>A	ENST00000327245.5	-	13	2338	c.1492A>T	c.(1492-1494)Agc>Tgc	p.S498C	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	498					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTTTTTGGCTTCTCATAGTT	0.582000													7	54					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47682233	47682233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47682233C>T	ENST00000273857.4	-	8	1056	c.1057G>A	c.(1057-1059)Ggg>Agg	p.G353R	CORIN_ENST00000502252.1_Missense_Mutation_p.G286R|CORIN_ENST00000505909.1_Intron|CORIN_ENST00000504584.1_Intron|CORIN_ENST00000508498.1_Missense_Mutation_p.G214R	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	353	LDL-receptor class A 3.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						ATGCAGCGCCCGTCCCCGCAG	0.532000													11	36					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645662	45645662	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:45645662G>A	ENST00000303230.4	-	2	531	c.474C>T	c.(472-474)gtC>gtT	p.V158V		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	158						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CTGGTATGATGACTAGATTTC	0.318000													30	66					0	0	1	0	0
CHKB-CPT1B	386593	broad.mit.edu	37	22	51017915	51017915	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:51017915G>A	ENST00000453634.1	-	2	47	c.48C>T	c.(46-48)ttC>ttT	p.F16F	CHKB-CPT1B_ENST00000452668.1_Intron|CHKB_ENST00000406938.2_Silent_p.F351F																							GACCCCAGAAGAAATGGGATG	0.562000													6	35					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45929264	45929264	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45929264G>A	ENST00000323084.4	-	10	1637	c.1572C>T	c.(1570-1572)ttC>ttT	p.F524F	TSPEAR-AS1_ENST00000451035.1_RNA|TSPEAR_ENST00000397916.1_Silent_p.F456F	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	524					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CTGCAGCACCGAACGTCTAGG	0.622000													8	30					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144620343	144620343	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144620343G>A	ENST00000262577.5	-	2	1225	c.1194C>T	c.(1192-1194)gcC>gcT	p.A398A		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	398					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CCTTGCTGCTGGCCTCCGACT	0.642000													21	71					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56387432	56387432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56387432C>T	ENST00000355701.3	-	21	4657	c.3787G>A	c.(3787-3789)Gaa>Aaa	p.E1263K	BZRAP1_ENST00000268893.6_Missense_Mutation_p.E1203K|BZRAP1_ENST00000343736.4_Missense_Mutation_p.E1263K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1263	Poly-Glu.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tcttcctcttcctcctGGATG	0.577000													28	65					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149905338	149905338	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:149905338G>A	ENST00000439741.2	-	10	1196	c.946C>T	c.(946-948)Caa>Taa	p.Q316*	MTMR11_ENST00000406732.3_Nonsense_Mutation_p.Q288*|MTMR11_ENST00000492824.1_5'UTR|MTMR11_ENST00000361405.6_Intron|MTMR11_ENST00000369140.3_Nonsense_Mutation_p.Q244*	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	316	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			TGGGCAAGTTGGACATCTGCA	0.582000													40	93					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55145665	55145665	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55145665C>T	ENST00000414150.2	+	13	2606	c.2328C>T	c.(2326-2328)tcC>tcT	p.S776S	MROH7_ENST00000339553.5_Silent_p.S776S|MROH7_ENST00000545244.1_Silent_p.S344S|MROH7_ENST00000454855.2_Silent_p.S294S|MROH7_ENST00000421030.2_Silent_p.S776S|MROH7_ENST00000409996.1_Silent_p.S344S|MROH7_ENST00000395690.2_Silent_p.S776S					maestro heat-like repeat family member 7																		TGGCTAGCTCCTTCATGACCG	0.607000													41	209					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78320047	78320047	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78320047C>T	ENST00000582970.1	+	29	8055	c.7912C>T	c.(7912-7914)Ctc>Ttc	p.L2638F	RNF213_ENST00000508628.2_Missense_Mutation_p.L2687F|RNF213_ENST00000336301.6_Missense_Mutation_p.L711F	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CTTTGTCAGCCTCAGGGACGT	0.537000													25	77					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7749579	7749579	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7749579C>T	ENST00000254846.5	+	6	809	c.420C>T	c.(418-420)ttC>ttT	p.F140F	KDM6B_ENST00000448097.2_Silent_p.F140F	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	140					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						GAGGAAGCTTCGCTGAGCTGG	0.622000													10	12					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47583854	47583854	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47583854C>T	ENST00000172229.3	+	3	527	c.402C>T	c.(400-402)ctC>ctT	p.L134L	NGFR_ENST00000504201.1_Silent_p.L40L|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	134					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GCTCGGGCCTCGTGTTCTCCT	0.692000													9	20					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135428793	135428793	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:135428793C>T	ENST00000394143.1	+	6	3219	c.2928C>T	c.(2926-2928)acC>acT	p.T976T	GPR112_ENST00000370652.1_Silent_p.T976T|GPR112_ENST00000287534.4_Silent_p.T913T|GPR112_ENST00000394141.1_Silent_p.T771T|GPR112_ENST00000412101.1_Silent_p.T771T	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	976					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TATCAGAAACCAGTTTCTCCA	0.512000													16	112					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113527243	113527243	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113527243G>A	ENST00000505019.1	-	9	2848	c.2723C>T	c.(2722-2724)tCt>tTt	p.S908F	C4orf21_ENST00000309071.5_Missense_Mutation_p.S908F	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	908										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TCCCGAGGAAGAGAACTAGGA	0.323000													31	69					0	0	1	0	0
CEBPE	1053	broad.mit.edu	37	14	23588189	23588189	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23588189C>T	ENST00000206513.5	-	1	636	c.112G>A	c.(112-114)Gcc>Acc	p.A38T		NM_001805.3	NP_001796.2	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein (C/EBP), epsilon	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		TCAATGGAGGCCTCATGCTCA	0.642000													21	94					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47583819	47583819	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47583819G>A	ENST00000172229.3	+	3	492	c.367G>A	c.(367-369)Gag>Aag	p.E123K	NGFR_ENST00000504201.1_Missense_Mutation_p.E29K|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	123					anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					TGGGCGCTGCGAGGCGTGCCG	0.697000													11	16					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105905303	105905303	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105905303T>C	ENST00000357060.3	-	31	3990	c.3875A>G	c.(3874-3876)aAa>aGa	p.K1292R	WDR96_ENST00000428666.1_Missense_Mutation_p.K1264R	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1292										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AAATTCCTTTTTAAAGCTGCG	0.363000													11	51					0	0	1	0	0
BNIPL	149428	broad.mit.edu	37	1	151015480	151015480	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151015480G>A	ENST00000295294.7	+	5	845	c.236G>A	c.(235-237)aGg>aAg	p.R79K	BNIPL_ENST00000368931.3_Missense_Mutation_p.R161K	NM_001159642.1	NP_001153114.1	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein like	161					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(1)|lung(4)|skin(1)	10	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACAGCTGAAAGGCTGGGCCGA	0.552000													55	105					0	0	1	0	0
OR4D11	219986	broad.mit.edu	37	11	59271300	59271300	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59271300C>T	ENST00000313253.1	+	1	252	c.252C>T	c.(250-252)gaC>gaT	p.D84D		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						TCTTGCTGGACCTTCTGTCAA	0.478000													92	241					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210948733	210948733	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:210948733G>A	ENST00000367007.4	-	10	2157	c.1988C>T	c.(1987-1989)tCc>tTc	p.S663F	KCNH1_ENST00000271751.4_Missense_Mutation_p.S690F	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	690					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CCGGGAGAAGGAATGGGAGAA	0.473000													18	31					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15073099	15073099	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15073099C>T	ENST00000598504.1	-	8	2009	c.650G>A	c.(649-651)gGg>gAg	p.G217E	SLC1A6_ENST00000544886.2_Missense_Mutation_p.G217E|SLC1A6_ENST00000221742.3_Missense_Mutation_p.G217E|SLC1A6_ENST00000430939.2_Missense_Mutation_p.G153E|SLC1A6_ENST00000600144.1_Missense_Mutation_p.G217E	NM_001272087.1	NP_001259016.1	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	217					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	CGGCTCAGACCCGTTCTCTGT	0.552000													15	142					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147494021	147494021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147494021G>A	ENST00000359874.3	+	21	2057	c.1984G>A	c.(1984-1986)Ggc>Agc	p.G662S	SPINK5_ENST00000398454.1_Missense_Mutation_p.G662S|SPINK5_ENST00000256084.7_Missense_Mutation_p.G662S	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	662	Kazal-like 10.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAGACCCATGGCAACAAGTG	0.458000													31	48					0	0	1	0	0
ACTR3B	57180	broad.mit.edu	37	7	152520487	152520487	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:152520487C>T	ENST00000256001.8	+	8	879	c.745C>T	c.(745-747)Ccc>Tcc	p.P249S	ACTR3B_ENST00000537264.1_Missense_Mutation_p.P161S|ACTR3B_ENST00000377776.3_Missense_Mutation_p.P249S|ACTR3B_ENST00000397282.2_Missense_Mutation_p.P161S	NM_020445.5	NP_065178.1	Q9P1U1	ARP3B_HUMAN	ARP3 actin-related protein 3 homolog B (yeast)	249					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding			breast(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	13		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		TGATGTGGATCCCCGGAAGTG	0.418000													71	136					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90012335	90012335	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90012335A>C	ENST00000405460.2	+	43	9332	c.9236A>C	c.(9235-9237)aAc>aCc	p.N3079T		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3079					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTATCATTTAACAACAGTGAG	0.388000													4	33					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127323759	127323759	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:127323759G>A	ENST00000265056.7	+	4	677	c.433G>A	c.(433-435)Gag>Aag	p.E145K		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	145	Interaction with MYST2 (By similarity).				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						GGAGGACGAGGAGCGCCCTGC	0.647000													12	20					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9609185	9609185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:9609185C>T	ENST00000310430.6	+	19	2925	c.2899C>T	c.(2899-2901)Cct>Tct	p.P967S	TNKS_ENST00000518281.1_Missense_Mutation_p.P730S	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	967					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		CTGTTTTAAACCTCAGGCTAC	0.488000													44	247					0	0	1	0	0
AMY2A	279	broad.mit.edu	37	1	104160591	104160591	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:104160591G>A	ENST00000414303.2	+	2	248	c.184G>A	c.(184-186)Gaa>Aaa	p.E62K		NM_000699.2	NP_000690.1	P04746	AMYP_HUMAN	amylase, alpha 2A (pancreatic)	62					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	TCCACCAAATGAAAATGTTGC	0.328000													39	170					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79725486	79725486	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:79725486C>T	ENST00000275034.4	-	14	1417	c.1250G>A	c.(1249-1251)gGa>gAa	p.G417E		NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	417					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		ATCTTCTATTCCTTGAAGGTT	0.303000													16	25					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1051955	1051955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1051955C>T	ENST00000263094.6	+	22	3208	c.2977C>T	c.(2977-2979)Ctc>Ttc	p.L993F	ABCA7_ENST00000433129.1_Missense_Mutation_p.L993F|ABCA7_ENST00000435683.2_Missense_Mutation_p.L855F	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	993	ABC transporter 1.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGCTGATCCTCTCCACCCA	0.672000													11	78					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12313759	12313759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12313759C>T	ENST00000256186.2	+	2	335	c.44C>T	c.(43-45)tCa>tTa	p.S15L		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	15	Ser-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		cctcttccttcatcgtcttcc	0.488000													15	45					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579081	44579081	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44579081G>A	ENST00000289547.4	-	2	970	c.915C>T	c.(913-915)ttC>ttT	p.F305F	NPC1L1_ENST00000423141.1_Silent_p.F305F|NPC1L1_ENST00000381160.3_Silent_p.F305F|NPC1L1_ENST00000546276.1_Silent_p.F305F	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	305					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GGGCCACACGGAATCCCACAA	0.602000													39	74					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143560784	143560784	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143560784C>T	ENST00000517894.1	+	8	2556	c.1662C>T	c.(1660-1662)ttC>ttT	p.F554F	BAI1_ENST00000323289.5_Silent_p.F554F			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	554	TSP type-1 5.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GGCCCTTCTTCGGGGGAGCAG	0.706000													7	10					0	0	1	0	0
WDR47	22911	broad.mit.edu	37	1	109529264	109529264	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109529264G>A	ENST00000357672.3	-	9	2097	c.1722C>T	c.(1720-1722)atC>atT	p.I574I	WDR47_ENST00000369965.4_Silent_p.I603I|WDR47_ENST00000400794.3_Silent_p.I610I|WDR47_ENST00000369962.3_Silent_p.I602I|WDR47_ENST00000361054.3_Silent_p.I574I			O94967	WDR47_HUMAN	WD repeat domain 47	602										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		TGTCTTCTAGGATATTAATAC	0.323000													20	43					0	0	1	0	0
AGBL4	84871	broad.mit.edu	37	1	49119122	49119122	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:49119122C>T	ENST00000371839.1	-	8	842	c.724_splice	c.e8-1	p.G242_splice	AGBL4_ENST00000371838.1_Splice_Site_p.G242_splice|AGBL4_ENST00000334103.7_5'UTR	NM_032785.3	NP_116174.3	Q5VU57	CBPC6_HUMAN	ATP/GTP binding protein-like 4	242					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15				Colorectal(2;0.00349)|COAD - Colon adenocarcinoma(2;0.0037)		AGTCAATGATCCCTAGGGAAA	0.453000													3	6					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27151188	27151188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27151188G>A	ENST00000288699.6	+	5	824	c.666G>A	c.(664-666)gaG>gaA	p.E222E	DPYSL5_ENST00000401478.1_Silent_p.E222E	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	222					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCGTCCAGAGGAGGTGAGAA	0.478000													8	32					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84531792	84531792	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:84531792C>T	ENST00000527857.1	+	0	1814					NR_026851.1																						CAATCCCAGCCCTACTACCTA	0.498000													15	30					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074263	9074263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9074263C>T	ENST00000397910.4	-	3	13386	c.13183G>A	c.(13183-13185)Gga>Aga	p.G4395R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4397	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGCAGCTCCAGTAGGACCT	0.463000													45	101					0	0	1	0	0
GPR35	2859	broad.mit.edu	37	2	241569451	241569451	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241569451G>A	ENST00000319838.5	+	6	1024	c.82G>A	c.(82-84)Ggc>Agc	p.G28S	GPR35_ENST00000438013.2_Missense_Mutation_p.G59S|GPR35_ENST00000407714.1_Missense_Mutation_p.G28S|GPR35_ENST00000430267.1_Missense_Mutation_p.G28S|GPR35_ENST00000403859.1_Missense_Mutation_p.G28S	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	28						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		CGCCTACTTGGGCGTCCTGCT	0.627000													19	64					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57103257	57103257	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:57103257G>A	ENST00000439986.4	-	11	1141	c.1104C>T	c.(1102-1104)ttC>ttT	p.F368F	CCBE1_ENST00000398179.2_Silent_p.F97F	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	368					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				GAGGTAAAGGGAACTCCTCTG	0.532000													55	163					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13071780	13071780	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:13071780G>A	ENST00000399002.2	+	5	931	c.657G>A	c.(655-657)ctG>ctA	p.L219L	SPTLC3_ENST00000378194.4_Silent_p.L219L	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	219					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	CTAAGTTCCTGAATGTGGAAG	0.428000													15	137					0	0	1	0	0
ZNF385D	79750	broad.mit.edu	37	3	21478515	21478515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:21478515G>A	ENST00000281523.2	-	5	1138	c.620C>T	c.(619-621)tCg>tTg	p.S207L	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	207						nucleus	nucleic acid binding|zinc ion binding	p.S207L(1)		NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						CTTGCATAGCGAACAGTAAAG	0.478000													17	125					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127253908	127253908	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:127253908G>A	ENST00000341640.2	-	4	645	c.440C>T	c.(439-441)cCc>cTc	p.P147L	PAX4_ENST00000463946.1_Missense_Mutation_p.P145L|PAX4_ENST00000338516.3_Missense_Mutation_p.P155L|PAX4_ENST00000378740.2_Missense_Mutation_p.P147L	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	155					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P147L(1)		cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GCCACTATGGGGAGTGAGGAC	0.562000													13	51					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31852266	31852266	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31852266G>A	ENST00000395728.3	-	20	2844	c.2845C>T	c.(2845-2847)Ccc>Tcc	p.P949S	EHMT2_ENST00000375528.4_Missense_Mutation_p.P915S|EHMT2_ENST00000375530.4_Missense_Mutation_p.P858S|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375537.4_Missense_Mutation_p.P892S			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	892					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						GAGCGCTCGGGAGTCAGGTCC	0.602000													42	109					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047750	9047750	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9047750G>A	ENST00000397910.4	-	5	34084	c.33881C>T	c.(33880-33882)tCt>tTt	p.S11294F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11296	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGACTGTAGAAGGCATAGT	0.473000													9	26					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104640107	104640107	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:104640107G>A	ENST00000315264.7	+	9	1893	c.1515G>A	c.(1513-1515)agG>agA	p.R505R	KIF26A_ENST00000423312.2_Silent_p.R644R			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	644	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CGGCTGGCAGGGCCGGGGAGG	0.667000													12	18					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1403202	1403202	+	Silent	SNP	G	G	A	rs138475489	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:1403202G>A	ENST00000270349.9	-	13	1729	c.1602C>T	c.(1600-1602)ttC>ttT	p.F534F	SLC6A3_ENST00000453492.2_Silent_p.F534F	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	534					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CCACGACCACGAACTGCAACC	0.632000													9	17					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	98002508	98002508	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98002508C>T	ENST00000224337.5	-	3	287	c.146G>A	c.(145-147)cGa>cAa	p.R49Q	BLNK_ENST00000413476.2_Missense_Mutation_p.R49Q|BLNK_ENST00000495266.1_Missense_Mutation_p.R49Q|BLNK_ENST00000427367.2_Missense_Mutation_p.R49Q|BLNK_ENST00000371176.2_Missense_Mutation_p.R49Q	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	49					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		GTAGTCCCTTCGAGGAACACT	0.388000													44	81					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29284944	29284944	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29284944G>A	ENST00000266943.6	-	4	1466	c.1097C>T	c.(1096-1098)tCt>tTt	p.S366F	SLC46A3_ENST00000380814.4_Missense_Mutation_p.S366F	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	366					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		CCGTAGAACAGAGAATGGCAC	0.388000													32	88					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242812010	242812010	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242812010G>A	ENST00000343216.3	+	1	130	c.102G>A	c.(100-102)ctG>ctA	p.L34L		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	34						integral to membrane											AGCACAGCCTGGTCCCGGGAT	0.682000													7	9					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154492783	154492783	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154492783G>A	ENST00000368482.4	+	5	983	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	TDRD10_ENST00000368480.3_Missense_Mutation_p.E49K	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	49	RRM.						nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GTTGTAGGAGGAAATTCTGTA	0.423000													20	43					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030026	95030026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95030026G>A	ENST00000557004.1	+	2	628	c.207G>A	c.(205-207)gaG>gaA	p.E69E	SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000298841.5_Silent_p.E69E|SERPINA4_ENST00000555095.1_Silent_p.E69E			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	69					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		TCGCTTCGGAGACCCCGGGGA	0.602000													35	79					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136529031	136529031	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:136529031T>A	ENST00000371872.4	-	21	2994	c.2737A>T	c.(2737-2739)Agg>Tgg	p.R913W	SARDH_ENST00000439388.1_Missense_Mutation_p.R913W|SARDH_ENST00000371868.1_Missense_Mutation_p.R363W|SARDH_ENST00000422262.2_Missense_Mutation_p.R745W	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	913					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CCCTTCACCCTCTTGTTGTTG	0.592000													35	121					0	0	1	0	0
ANXA9	8416	broad.mit.edu	37	1	150955861	150955861	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150955861C>T	ENST00000368947.4	+	4	599	c.123C>T	c.(121-123)ttC>ttT	p.F41F	ANXA9_ENST00000474997.1_3'UTR	NM_003568.2	NP_003559.2	O76027	ANXA9_HUMAN	annexin A9	41					cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(4)|skin(2)	8	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTTGAACTTCAGCGTGGACA	0.607000													7	17					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3795352	3795352	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3795352G>A	ENST00000262367.5	-	22	4649	c.3840C>T	c.(3838-3840)ttC>ttT	p.F1280F	CREBBP_ENST00000382070.3_Silent_p.F1242F	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1280	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGCAATCAACGAAACTAGGAG	0.512000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						10	21					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41385254	41385254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41385254G>A	ENST00000400454.1	-	33	6223	c.5746C>T	c.(5746-5748)Cca>Tca	p.P1916S		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1916				HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTGGTGCCTGGACCACCTCGG	0.522000													23	43					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588200	247588200	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247588200G>A	ENST00000366497.2	+	4	2235	c.1455G>A	c.(1453-1455)gaG>gaA	p.E485E	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Silent_p.E485E|NLRP3_ENST00000336119.3_Silent_p.E485E|NLRP3_ENST00000348069.2_Silent_p.E485E|NLRP3_ENST00000391828.3_Silent_p.E485E|NLRP3_ENST00000391827.2_Silent_p.E485E	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	485	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCCTGTTTGAGGAGTCCGACC	0.567000													14	35					0	0	1	0	0
PPM1D	8493	broad.mit.edu	37	17	58734141	58734141	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:58734141C>T	ENST00000305921.3	+	5	1431	c.1199C>T	c.(1198-1200)tCc>tTc	p.S400F		NM_003620.3	NP_003611.1	O15297	PPM1D_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1D	400					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			GACAGCCCTTCCTATAATAGT	0.393000													43	93					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124412747	124412747	+	Silent	SNP	C	C	T	rs61745404	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124412747C>T	ENST00000306842.2	-	1	828	c.804G>A	c.(802-804)gaG>gaA	p.E268E		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		CTTTCCCTTGCTCGAGGGGCA	0.438000													24	73					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233296028	233296028	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233296028C>T	ENST00000258229.8	-	19	3752		c.e19+1		PCNXL2_ENST00000488780.2_Splice_Site|PCNXL2_ENST00000520463.1_Splice_Site	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				ATATTACTAACCTCTCACTTC	0.418000													14	29					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849774	73849774	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:73849774G>A	ENST00000523207.1	+	3	2772	c.2184G>A	c.(2182-2184)caG>caA	p.Q728Q		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	728					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GTGCACCACAGACCCCGCCCA	0.532000													56	110					0	0	1	0	0
GLI1	2735	broad.mit.edu	37	12	57864435	57864435	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57864435A>G	ENST00000228682.2	+	12	2003	c.1912A>G	c.(1912-1914)Agg>Ggg	p.R638G	GLI1_ENST00000543426.1_Missense_Mutation_p.R510G|GLI1_ENST00000546141.1_Missense_Mutation_p.R597G	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	638					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			GGTCACCCGGAGGGCCAGTGA	0.622000													18	46					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62855838	62855838	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:62855838G>A	ENST00000584306.1	-	11	4956	c.4426C>T	c.(4426-4428)Cag>Tag	p.Q1476*	LRRC37A3_ENST00000400877.3_Nonsense_Mutation_p.Q514*|LRRC37A3_ENST00000334962.5_Nonsense_Mutation_p.Q453*|LRRC37A3_ENST00000319651.5_Nonsense_Mutation_p.Q1476*|LRRC37A3_ENST00000339474.5_Nonsense_Mutation_p.Q594*	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1476						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TGGGTTAGCTGAATTTCAAAC	0.512000													119	328					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115428861	115428861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:115428861C>T	ENST00000369522.3	+	14	1361	c.1121C>T	c.(1120-1122)tCg>tTg	p.S374L	SYCP1_ENST00000369518.1_Missense_Mutation_p.S374L	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	374					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTGCTCATTCGTTTGTGGTT	0.308000													48	104					0	0	1	0	0
SLC25A52	147407	broad.mit.edu	37	18	29340392	29340392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29340392C>T	ENST00000269205.5	-	1	451	c.263G>A	c.(262-264)cGa>cAa	p.R88Q	SLC25A52_ENST00000579441.2_Missense_Mutation_p.R78Q	NM_001034172.2	NP_001029344.3	Q3SY17	MCAR2_HUMAN	solute carrier family 25, member 52	78					transport	integral to membrane|mitochondrial inner membrane											ATACAAATTTCGAAATCCATC	0.463000													43	85					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	145002	145002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145002C>T	ENST00000283426.6	+	4	854	c.804C>T	c.(802-804)gcC>gcT	p.A268A		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	268					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GTCCAGCTGCCCCTGCCGTCT	0.612000													14	34					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375885	113375885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:113375885G>A	ENST00000316407.4	-	7	5054	c.4644C>T	c.(4642-4644)tcC>tcT	p.S1548S	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Silent_p.S1548S	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1548	Gln-rich.				regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TCTTGGATCGGGATTGGTCAG	0.502000													15	70					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116631459	116631459	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:116631459G>T	ENST00000395715.3	-	3	1443	c.866C>A	c.(865-867)tCc>tAc	p.S289Y	TRPS1_ENST00000520276.1_Missense_Mutation_p.S280Y|TRPS1_ENST00000220888.5_Missense_Mutation_p.S276Y|TRPS1_ENST00000519674.1_Missense_Mutation_p.S276Y|TRPS1_ENST00000519076.1_Missense_Mutation_p.S230Y	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	276					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GAAGTCTTTGGAATGGCTGAA	0.468000									Langer-Giedion syndrome				28	38					1.74197e-06	1.74599e-06	1	1	0
SQLE	6713	broad.mit.edu	37	8	126015634	126015634	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:126015634G>A	ENST00000265896.5	+	2	1406	c.508G>A	c.(508-510)Ggt>Agt	p.G170S	SQLE_ENST00000523430.1_Missense_Mutation_p.G75S	NM_003129.3	NP_003120.2	Q14534	ERG1_HUMAN	squalene epoxidase	170					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	CCTGCAGCCGGGTGGTTATCA	0.443000													50	225					0	0	1	0	0
RORB	6096	broad.mit.edu	37	9	77286782	77286782	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77286782C>T	ENST00000376896.2	+	9	1801	c.1189C>T	c.(1189-1191)Cag>Tag	p.Q397*	RORB_ENST00000396204.2_Nonsense_Mutation_p.Q408*	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	408	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						ACATGTGATTCAGAAGAATCA	0.443000													20	42					0	0	1	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182195	100182195	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100182195C>T	ENST00000554176.1	+	3	949	c.283C>T	c.(283-285)Cgc>Tgc	p.R95C	CYP46A1_ENST00000261835.3_Missense_Mutation_p.R248C|CYP46A1_ENST00000423126.2_Missense_Mutation_p.R151C			Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	248					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GGAGAGCATTCGCTTCCTGCG	0.607000													34	59					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156646890	156646890	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156646890G>A	ENST00000368223.3	-	1	299	c.167C>T	c.(166-168)gCc>gTc	p.A56V		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	56	Coil 1B.|Rod.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCGTCGTCGGCATGCGCCCG	0.721000													8	15					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72350309	72350309	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72350309G>A	ENST00000389916.4	+	18	2455	c.2317G>A	c.(2317-2319)Gag>Aag	p.E773K		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	773					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						AGAGAGGAAGGAGATCCTGAC	0.657000													34	94					0	0	1	0	0
LNX2	222484	broad.mit.edu	37	13	28136759	28136759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:28136759G>A	ENST00000316334.3	-	5	1144	c.1015C>T	c.(1015-1017)Caa>Taa	p.Q339*		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	339	PDZ 2.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		AGAGCCACTTGGAAAATCTCT	0.488000													31	92					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38750779	38750779	+	Splice_Site	SNP	G	G	A	rs35125773		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38750779G>A	ENST00000359357.3	+	15	1862		c.e15-1		DNAH8_ENST00000449981.2_Splice_Site|DNAH8_ENST00000441566.1_Splice_Site					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TAAAAAAACAGAAAAACTCAG	0.323000													17	52					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092458	30092458	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30092458C>T	ENST00000567636.1	+	0	833					NR_003558.1																						GATGTATGGCCGTAAAGTGGG	0.532000													53	103					0	0	1	0	0
TULP2	7288	broad.mit.edu	37	19	49391246	49391246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49391246G>A	ENST00000221399.3	-	8	1053	c.909C>T	c.(907-909)ccC>ccT	p.P303P		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	303					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GGTAGTAGAGGGGGAACAAGC	0.612000													18	61					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831246	61831246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61831246G>A	ENST00000280772.1	-	37	9584	c.9393C>T	c.(9391-9393)acC>acT	p.T3131T	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3131					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTGTATAAAAGGTCCCCCTGG	0.408000													43	184					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25333878	25333878	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25333878C>T	ENST00000546682.1	+	0	586				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						GTTGTTGGATCCCTTCTGAAT	0.478000													30	49					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272052	52272052	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52272052G>A	ENST00000598776.1	+	2	913	c.141G>A	c.(139-141)gtG>gtA	p.V47V	FPR2_ENST00000340023.6_Silent_p.V47V|FPR2_ENST00000598953.1_Silent_p.V47V	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	47					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						ATGGGCTTGTGATCTGGGTGG	0.557000													27	84					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10480586	10480586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:10480586C>T	ENST00000382483.3	-	2	349	c.126G>A	c.(124-126)ggG>ggA	p.G42G	RP1L1_ENST00000329335.3_5'UTR	NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	42					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		ACCGTGGATCCCCTCGCTTGA	0.652000													30	61					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332205	70332205	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70332205G>A	ENST00000338508.4	-	32	4195	c.4196C>T	c.(4195-4197)tCc>tTc	p.S1399F	SHANK2_ENST00000449833.2_Missense_Mutation_p.S803F|SHANK2_ENST00000423696.2_Missense_Mutation_p.S1019F|SHANK2_ENST00000409161.1_Missense_Mutation_p.S802F			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1019					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CAAGTCCACGGATGCCAGAGG	0.567000													29	70					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578475	7578475	+	Missense_Mutation	SNP	G	G	A	rs137852790		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7578475G>A	ENST00000420246.2	-	5	587	c.455C>T	c.(454-456)cCg>cTg	p.P152L	TP53_ENST00000445888.2_Missense_Mutation_p.P152L|TP53_ENST00000455263.2_Missense_Mutation_p.P152L|TP53_ENST00000413465.2_Missense_Mutation_p.P152L|TP53_ENST00000269305.4_Missense_Mutation_p.P152L|TP53_ENST00000359597.4_Missense_Mutation_p.P152L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	152	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		P -> A (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(66)|p.P152R(8)|p.0?(8)|p.T150fs*16(6)|p.?(5)|p.P153fs*28(5)|p.P152fs*18(5)|p.P152fs*14(5)|p.P152Q(4)|p.P59L(2)|p.P20L(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P59R(1)|p.P20R(1)|p.P152fs*28(1)|p.T57fs*16(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.P152fs*27(1)|p.Q144_G154del11(1)|p.Q144fs*16(1)|p.T18fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGCCGGGCGGGGGTGTGGA	0.612000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			28	41					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247751770	247751770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247751770C>T	ENST00000320065.1	+	1	109	c.109C>T	c.(109-111)Ctg>Ttg	p.L37L	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATATTGATTCTGTATTTACT	0.398000													61	149					0	0	1	0	0
CDK19	23097	broad.mit.edu	37	6	110942510	110942510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:110942510G>A	ENST00000368911.3	-	12	1353	c.1174C>T	c.(1174-1176)Cct>Tct	p.P392S	CDK19_ENST00000413605.2_Missense_Mutation_p.P268S|CDK19_ENST00000323817.3_Missense_Mutation_p.P332S	NM_015076.3	NP_055891.1	Q9BWU1	CDK19_HUMAN	cyclin-dependent kinase 19	392	Gln-rich.						ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)	22						GCCTGTGGAGGGGCTGCTGCC	0.632000													61	84					0	0	1	0	0
RSL1D1	26156	broad.mit.edu	37	16	11941590	11941590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11941590G>A	ENST00000571133.1	-	3	391	c.319C>T	c.(319-321)Cct>Tct	p.P107S	RSL1D1_ENST00000542106.1_5'UTR	NM_015659.2	NP_056474.2	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	107					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	15						GTCTTTTCAGGAGTTGAATTG	0.348000													12	48					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37467050	37467050	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37467050G>A	ENST00000381792.2	-	14	1718	c.1578C>T	c.(1576-1578)acC>acT	p.T526T	TMPRSS6_ENST00000406725.1_Silent_p.T526T|TMPRSS6_ENST00000406856.1_Silent_p.T526T|TMPRSS6_ENST00000346753.3_Silent_p.T535T			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	535	LDL-receptor class A 2.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						CACACTGGAAGGTGAATGTCC	0.637000													15	35					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23410682	23410682	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:23410682C>T	ENST00000379361.4	+	3	1907	c.1047C>T	c.(1045-1047)tcC>tcT	p.S349S		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	349	SSD.				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						AAATGTTATCCTCCTGGAGGA	0.418000													28	11					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4854665	4854665	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:4854665C>T	ENST00000252318.2	+	5	1268	c.931C>T	c.(931-933)Cgt>Tgt	p.R311C		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	311						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						TGACAACATTCGTTTTGACAC	0.498000													25	39					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117307098	117307098	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117307098C>T	ENST00000003084.6	+	27	4511	c.4379C>T	c.(4378-4380)tCt>tTt	p.S1460F	CFTR_ENST00000454343.1_Missense_Mutation_p.S1399F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1460					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AAGTGCAAGTCTAAGCCCCAG	0.512000									Cystic Fibrosis				13	49					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15364971	15364971	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15364971G>A	ENST00000263377.2	-	11	2371	c.2150C>T	c.(2149-2151)tCc>tTc	p.S717F	BRD4_ENST00000360016.5_Missense_Mutation_p.S717F|BRD4_ENST00000371835.4_Missense_Mutation_p.S717F	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	717	Ser-rich.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			ACCTGTTTCGGAGTCTTCGCT	0.547000			T	C15orf55	lethal midline carcinoma of young people								7	43					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21453372	21453372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:21453372C>T	ENST00000307378.6	-	9	1540	c.820G>A	c.(820-822)Gga>Aga	p.G274R	SLCO1A2_ENST00000537524.1_Missense_Mutation_p.G142R|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.G142R|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.G272R|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.G274R	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	274					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						GTCTCTAGTCCTTCCTTTGGA	0.388000													13	52					0	0	1	0	0
ZNF215	7762	broad.mit.edu	37	11	6953543	6953543	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6953543C>T	ENST00000278319.5	+	3	628	c.40C>T	c.(40-42)Cga>Tga	p.R14*	ZNF215_ENST00000414517.2_Nonsense_Mutation_p.R14*|ZNF215_ENST00000527171.1_3'UTR|ZNF215_ENST00000529903.1_Nonsense_Mutation_p.R14*	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	14					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CTCAAAACCTCGAAACCTGTC	0.468000													33	73					0	0	1	0	0
SLAMF8	56833	broad.mit.edu	37	1	159802914	159802914	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159802914C>T	ENST00000289707.5	+	3	765	c.616C>T	c.(616-618)Cct>Tct	p.P206S	SLAMF8_ENST00000368104.4_Missense_Mutation_p.P97S|SLAMF8_ENST00000471286.1_3'UTR	NM_020125.2	NP_064510.1	Q9P0V8	SLAF8_HUMAN	SLAM family member 8	206	Ig-like C2-type.					integral to membrane				endometrium(2)|large_intestine(4)|lung(6)	12	all_hematologic(112;0.0597)					TGTCTCCAACCCTGTCAGCTG	0.557000													31	81					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22834550	22834550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22834550C>T	ENST00000404138.1	+	8	1928	c.1417C>T	c.(1417-1419)Ctc>Ttc	p.L473F	ZBTB40_ENST00000374651.4_Missense_Mutation_p.L361F|ZBTB40_ENST00000375647.4_Missense_Mutation_p.L473F	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	473					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TCATGAAAACCTCTCTGAGAT	0.393000													31	108					0	0	1	0	0
TOB2	10766	broad.mit.edu	37	22	41833288	41833288	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41833288G>A	ENST00000327492.3	-	2	768	c.62C>T	c.(61-63)cCc>cTc	p.P21L		NM_016272.3	NP_057356.1	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	21					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						CCGGCGCCGGGGCAGCTTGTT	0.537000													34	53					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93017372	93017372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:93017372C>T	ENST00000523629.1	-	6	1166	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K	RUNX1T1_ENST00000521553.1_Missense_Mutation_p.E201K|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.E249K|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.E201K|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.E211K|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.E201K|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.E238K|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.E201K|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.E211K	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	238					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E238K(1)|p.E201K(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCCCGTTTTCGTTCACATCG	0.542000													15	127					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	5605450	5605450	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:5605450C>T	ENST00000215473.6	+	6	3490	c.3490C>T	c.(3490-3492)Cta>Tta	p.L1164L				Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	1164					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GGCCTCTGCTCTATGCCACAG	0.552000													37	19					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159141570	159141570	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159141570C>T	ENST00000368125.4	+	1	172	c.15C>T	c.(13-15)gcC>gcT	p.A5A	CADM3_ENST00000368124.4_Silent_p.A5A	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	5					adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					GGGCCCCAGCCGCCTCGCTCC	0.751000													3	3					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73735384	73735384	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:73735384G>A	ENST00000427855.1	+	26	3722	c.3620G>A	c.(3619-3621)gGg>gAg	p.G1207E	PAPLN_ENST00000554301.1_Missense_Mutation_p.G1207E|PAPLN_ENST00000381166.3_Intron|PAPLN_ENST00000340738.5_Missense_Mutation_p.G1180E|PAPLN_ENST00000555445.1_Missense_Mutation_p.G1191E			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	1207	Ig-like C2-type 3.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCCTACCAGGGGAGCCAGGCA	0.592000													14	31					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13841134	13841134	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13841134G>A	ENST00000265104.4	-	34	5694	c.5590C>T	c.(5590-5592)Ctg>Ttg	p.L1864L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1864	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGTAGCTCCAGGAAAGCCTGA	0.403000									Kartagener syndrome				23	73					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27147881	27147881	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27147881C>A	ENST00000288699.6	+	3	546	c.388C>A	c.(388-390)Ctc>Atc	p.L130I	DPYSL5_ENST00000401478.1_Missense_Mutation_p.L130I	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	130					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATTACGCCCTCCACGTGGG	0.607000													13	33					0.000151284	0.000151513	1	1	0
PEAK1	79834	broad.mit.edu	37	15	77471795	77471795	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:77471795G>A	ENST00000560626.2	-	4	2949	c.2474C>T	c.(2473-2475)cCt>cTt	p.P825L	PEAK1_ENST00000558305.1_Missense_Mutation_p.P825L|PEAK1_ENST00000312493.4_Missense_Mutation_p.P825L			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	825	Pro-rich.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										CTCACCACTAGGCTGAGATGT	0.502000													36	129					0	0	1	0	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89916703	89916703	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:89916703G>A	ENST00000548729.1	-	3	1917	c.1615C>T	c.(1615-1617)Cca>Tca	p.P539S	GALNT4_ENST00000529983.2_Missense_Mutation_p.P542S|POC1B_ENST00000541909.1_Intron|POC1B-GALNT4_ENST00000413530.1_Missense_Mutation_p.P370S|POC1B_ENST00000549504.1_Intron|POC1B_ENST00000393179.4_Intron|POC1B-GALNT4_ENST00000547474.1_3'UTR|POC1B_ENST00000549035.1_Intron|POC1B_ENST00000313546.3_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					CCTGAGTGTGGGTGAAAAATA	0.403000													9	77					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908686	103908686	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103908686C>T	ENST00000302259.3	+	1	1379	c.1136C>T	c.(1135-1137)tCt>tTt	p.S379F	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	379					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CAAGATGAGTCTTCGGACAAG	0.463000													16	57					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56742819	56742819	+	Missense_Mutation	SNP	G	G	A	rs149351309		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56742819G>A	ENST00000314128.4	-	17	1488	c.1465C>T	c.(1465-1467)Ccc>Tcc	p.P489S	STAT2_ENST00000556539.1_5'UTR|STAT2_ENST00000418572.2_3'UTR|STAT2_ENST00000557235.1_Missense_Mutation_p.P485S			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	489					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						GGGGCCTTGGGGGGGTTGGAG	0.602000													18	52					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17084760	17084760	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:17084760G>A	ENST00000455405.2	-	0	256																											TCCTTTACTAGAGACCCCGCG	0.572000													8	35					0	0	1	0	0
CEACAM7	1087	broad.mit.edu	37	19	42187864	42187864	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42187864G>A	ENST00000006724.3	-	3	759	c.558C>T	c.(556-558)ctC>ctT	p.L186L	CEACAM7_ENST00000401731.1_Silent_p.L186L|CEACAM7_ENST00000602225.1_Intron|CEACAM7_ENST00000338196.4_Intron	NM_006890.3	NP_008821.1	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 7	186	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		GACTGACCAGGAGGCTCTGAT	0.478000													47	113					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189586385	189586385	+	Nonsense_Mutation	SNP	C	C	T	rs113993966		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:189586385C>T	ENST00000264731.3	+	8	1098	c.1009C>T	c.(1009-1011)Cga>Tga	p.R337*	TP63_ENST00000392460.3_Nonsense_Mutation_p.R337*|TP63_ENST00000449992.1_Nonsense_Mutation_p.R158*|TP63_ENST00000392463.2_Nonsense_Mutation_p.R243*|TP63_ENST00000440651.2_Nonsense_Mutation_p.R337*|TP63_ENST00000320472.5_Nonsense_Mutation_p.R337*|TP63_ENST00000392461.3_Nonsense_Mutation_p.R243*|TP63_ENST00000382063.4_Nonsense_Mutation_p.R252*|TP63_ENST00000456148.1_Nonsense_Mutation_p.R243*|TP63_ENST00000437221.1_Nonsense_Mutation_p.R243*|TP63_ENST00000354600.5_Nonsense_Mutation_p.R243*|TP63_ENST00000418709.2_Nonsense_Mutation_p.R337*	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	337			R -> Q (in ADULT syndrome; confers novel transcription activation capacity on isoform 6).		anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		AGTCCTGGGCCGACGCTGCTT	0.478000										HNSCC(45;0.13)			17	68					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81050844	81050844	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81050844C>T	ENST00000334512.5	+	10	1241	c.669C>T	c.(667-669)ttC>ttT	p.F223F	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	223					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGCAGCAGTTCTCAGCCAAGG	0.662000													39	67					0	0	1	0	0
PCBP2	5094	broad.mit.edu	37	12	53853075	53853075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53853075C>T	ENST00000603815.1	+	6	613	c.263C>T	c.(262-264)aCc>aTc	p.T88I	PCBP2_ENST00000359282.5_Missense_Mutation_p.T88I|PCBP2_ENST00000541275.1_Missense_Mutation_p.T88I|PCBP2_ENST00000359462.5_Missense_Mutation_p.T88I|PCBP2_ENST00000447282.1_Missense_Mutation_p.T88I|PCBP2_ENST00000546463.1_Missense_Mutation_p.T88I|PCBP2_ENST00000548933.1_Missense_Mutation_p.T88I|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000437231.1_Missense_Mutation_p.T88I|PCBP2_ENST00000552296.2_Missense_Mutation_p.T88I|PCBP2_ENST00000455667.3_Missense_Mutation_p.T88I|PCBP2_ENST00000549863.1_Missense_Mutation_p.T88I|PCBP2_ENST00000552819.1_Missense_Mutation_p.T88I|PCBP2_ENST00000439930.3_Missense_Mutation_p.T88I	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	88					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						AGCTCTATGACCAATAGCACA	0.483000													31	98					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74401374	74401374	+	Silent	SNP	G	G	A	rs144543657	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74401374G>A	ENST00000319380.7	-	3	565	c.501C>T	c.(499-501)atC>atT	p.I167I		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	167							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						TGTTGACGTCGATCACCGTGC	0.622000													18	42					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112786202	112786202	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:112786202G>A	ENST00000295408.4	+	19	3018	c.2761G>A	c.(2761-2763)Gac>Aac	p.D921N	MERTK_ENST00000421804.2_Missense_Mutation_p.D921N|MERTK_ENST00000409780.1_Missense_Mutation_p.D745N			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	921					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						AGAAGTTCATGACAGCAAACC	0.537000													43	113					0	0	1	0	0
TDO2	6999	broad.mit.edu	37	4	156838606	156838606	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156838606C>T	ENST00000536354.2	+	10	1020	c.956C>T	c.(955-957)tCa>tTa	p.S319L		NM_005651.3	NP_005642.1	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	319					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	18	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	GACATAGATTCACTGATGACC	0.433000													21	83					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938364	2938364	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2938364C>T	ENST00000378404.2	+	1	319	c.114C>T	c.(112-114)atC>atT	p.I38I		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	38						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		TCAGCTCCATCGTGGGGCACC	0.597000													15	38					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94884139	94884139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94884139G>A	ENST00000357742.4	+	6	955	c.955G>A	c.(955-957)Gat>Aat	p.D319N	MCTP2_ENST00000543482.1_Missense_Mutation_p.D319N|MCTP2_ENST00000451018.3_Missense_Mutation_p.D319N|MCTP2_ENST00000331706.4_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	319					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAAACAGGGTGATTTCAAGAG	0.373000													14	67					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481610	140481610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140481610C>T	ENST00000231130.2	+	1	1377	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		459	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.F459F(1)		NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.602000													86	199					0	0	1	0	0
ZNF439	90594	broad.mit.edu	37	19	11978185	11978185	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11978185C>T	ENST00000304030.2	+	3	501	c.301C>T	c.(301-303)Cca>Tca	p.P101S	ZNF439_ENST00000592534.1_Intron|ZNF439_ENST00000455282.1_5'UTR	NM_152262.2	NP_689475.1	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	101	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(7)|pancreas(1)|skin(2)	27						AACTTTTACCCCAGTTCCAGA	0.388000													16	219					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67064772	67064772	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:67064772G>A	ENST00000315962.4	+	8	1519	c.1146G>A	c.(1144-1146)gtG>gtA	p.V382V	TRIM55_ENST00000350034.4_Intron|TRIM55_ENST00000276573.7_Silent_p.V382V|TRIM55_ENST00000353317.5_Silent_p.V382V	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	382						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			TCTCTCAGGTGGAGCTGCAGG	0.552000													15	67					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96967012	96967012	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96967012C>T	ENST00000341686.3	+	4	576	c.451C>T	c.(451-453)Cgc>Tgc	p.R151C	C10orf129_ENST00000430183.1_5'UTR|C10orf129_ENST00000394005.3_Missense_Mutation_p.R151C	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	151					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CAAGAAAATTCGCTATCAATT	0.458000													19	74					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47489498	47489498	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47489498C>T	ENST00000371901.3	+	1	259	c.9C>T	c.(7-9)ttC>ttT	p.F3F	CYP4X1_ENST00000538609.1_Intron	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	3						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						CCATGGAATTCTCCTGGCTGG	0.697000													16	68					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143013423	143013423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143013423G>A	ENST00000343257.2	+	1	205	c.118G>A	c.(118-120)Ggg>Agg	p.G40R		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	40					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CTCTGAGAATGGGGGCCTCCA	0.607000													47	131					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119463029	119463029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:119463029G>A	ENST00000273390.5	+	14	1965	c.1888G>A	c.(1888-1890)Gag>Aag	p.E630K	RP11-169N13.4_ENST00000489428.2_RNA	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		GGAGGAGGACGAGATATTTAA	0.562000													17	38					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33998705	33998705	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:33998705C>T	ENST00000373381.4	-	64	10292	c.10116G>A	c.(10114-10116)gaG>gaA	p.E3372E		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3228						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGGTGCGGTGCTCGGAGCCAC	0.662000													17	22					0	0	1	0	0
NFIC	4782	broad.mit.edu	37	19	3449086	3449086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3449086C>T	ENST00000589123.1	+	7	1126	c.1006C>T	c.(1006-1008)Cgc>Tgc	p.R336C	NFIC_ENST00000346156.5_Missense_Mutation_p.R312C|NFIC_ENST00000341919.3_Missense_Mutation_p.R345C|NFIC_ENST00000590282.1_Missense_Mutation_p.R345C|NFIC_ENST00000586919.1_Missense_Mutation_p.R312C|NFIC_ENST00000443272.2_Missense_Mutation_p.R345C|NFIC_ENST00000395111.3_Missense_Mutation_p.R336C	NM_001245005.1|NM_205843.2	NP_001231934.1|NP_995315.1	P08651	NFIC_HUMAN	nuclear factor I/C (CCAAT-binding transcription factor)	345					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		GGACTCTCCCCGCCTCTCCAG	0.672000													21	26					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14834375	14834375	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14834375G>A	ENST00000261170.3	-	5	784	c.648C>T	c.(646-648)ttC>ttT	p.F216F	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	216					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						GTTCGTGGGAGAAATAGGAAA	0.418000													14	64					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70931458	70931458	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70931458G>A	ENST00000264436.3	-	4	761	c.317C>T	c.(316-318)tCc>tTc	p.S106F	ADD2_ENST00000407644.2_Missense_Mutation_p.S106F|ADD2_ENST00000430656.1_Missense_Mutation_p.S122F|ADD2_ENST00000355733.3_Missense_Mutation_p.S106F|ADD2_ENST00000413157.2_Missense_Mutation_p.S106F	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	106					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CATACTCATGGAAGATGTCGG	0.602000													24	86					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184295503	184295503	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184295503C>T	ENST00000330394.2	+	7	1989	c.1537C>T	c.(1537-1539)Ctt>Ttt	p.L513F	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	513	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCTGGACGGGCTTCGGCCTGA	0.642000													34	93					0	0	1	0	0
EPC2	26122	broad.mit.edu	37	2	149511697	149511697	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:149511697C>T	ENST00000258484.6	+	4	695	c.661C>T	c.(661-663)Cga>Tga	p.R221*		NM_015630.3	NP_056445.3	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2 (Drosophila)	221					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		AATGCAAACTCGAAAGGTAAT	0.338000													6	13					0	0	1	0	0
NCK2	8440	broad.mit.edu	37	2	106509458	106509458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:106509458C>T	ENST00000451463.2	+	4	523	c.247C>T	c.(247-249)Cct>Tct	p.P83S	NCK2_ENST00000393349.2_Silent_p.S323S|NCK2_ENST00000233154.4_Silent_p.S323S|NCK2_ENST00000522586.1_Missense_Mutation_p.P83S	NM_001004722.3	NP_001004722.1	O43639	NCK2_HUMAN	NCK adaptor protein 2	0					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						TCTCCGTGTCCCTTAAAGCGT	0.567000													20	73					0	0	1	0	0
CSDC2	27254	broad.mit.edu	37	22	41968057	41968057	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41968057G>A	ENST00000306149.7	+	2	632	c.88G>A	c.(88-90)Gag>Aag	p.E30K		NM_014460.3	NP_055275.1	Q9Y534	CSDC2_HUMAN	cold shock domain containing C2, RNA binding	30					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|RNA binding			prostate(2)|upper_aerodigestive_tract(1)	3						CTTCCACAGGGAGGGCAGCAG	0.667000													4	7					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605745	171605745	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:171605745G>A	ENST00000037502.5	-	3	894	c.835C>T	c.(835-837)Ccc>Tcc	p.P279S		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	279	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGGGTGTAGGGGTAGGTGGGC	0.537000													46	62					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7295530	7295530	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7295530C>T	ENST00000537408.1	+	10	2180	c.1642C>T	c.(1642-1644)Cgc>Tgc	p.R548C	CLSTN3_ENST00000266546.6_Missense_Mutation_p.R536C			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	536					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						GCGCTCAGGTCGCCTGGAGAG	0.587000													17	45					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102508940	102508940	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:102508940C>T	ENST00000321521.9	+	20	2941	c.2368C>T	c.(2368-2370)Ctt>Ttt	p.L790F	PPIP5K2_ENST00000358359.3_Missense_Mutation_p.L790F|PPIP5K2_ENST00000414217.1_Missense_Mutation_p.L790F|PPIP5K2_ENST00000513500.1_3'UTR			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	790					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TCGCTCAGACCTTCAGAGGAC	0.363000													29	54					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31816148	31816148	+	Missense_Mutation	SNP	G	G	A	rs143438972	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:31816148G>A	ENST00000446923.2	+	9	3674	c.3283G>A	c.(3283-3285)Gag>Aag	p.E1095K	ZEB1_ENST00000361642.5_Missense_Mutation_p.E1112K|ZEB1_ENST00000542815.3_Missense_Mutation_p.E1044K|ZEB1_ENST00000320985.10_Missense_Mutation_p.E1111K|ZEB1_ENST00000560721.2_Missense_Mutation_p.E1091K	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	1111	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAAGTAGGCGAGAGTAGTGA	0.378000													10	19					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382676	22382676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22382676C>T	ENST00000328795.4	+	1	295	c.204C>T	c.(202-204)ttC>ttT	p.F68F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		ACTTGGCCTTCCTGGATGCAT	0.483000													29	284					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545019	82545019	+	Silent	SNP	G	G	A	rs76835434	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82545019G>A	ENST00000423517.2	-	7	12620	c.12283C>T	c.(12283-12285)Cta>Tta	p.L4095L	PCLO_ENST00000333891.8_Silent_p.L4095L|PCLO_ENST00000437081.1_Silent_p.L815L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4026					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AAAGGTGCTAGGAAATCTGTC	0.448000													7	20					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151878029	151878029	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:151878029G>A	ENST00000355193.2	-	36	7134	c.6916C>T	c.(6916-6918)Cca>Tca	p.P2306S	KMT2C_ENST00000262189.6_Missense_Mutation_p.P2306S					lysine (K)-specific methyltransferase 2C																		TGAGATCTTGGAGTCATTGGA	0.512000													31	67					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140207969	140207969	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140207969G>A	ENST00000529310.1	+	1	407	c.293G>A	c.(292-294)cGg>cAg	p.R98Q	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.R98Q	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1												p.R98Q(2)		NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGTGCGGGCGGAGCGCGGAG	0.587000													93	303					0	0	1	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89100768	89100768	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89100768G>A	ENST00000393525.3	+	0	1242																											TAAATGAATTGAATCATTTGA	0.333000													22	49					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76928222	76928222	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:76928222C>T	ENST00000376217.2	-	17	1882	c.1632G>A	c.(1630-1632)aaG>aaA	p.K544K	GDPD4_ENST00000315938.4_3'UTR			Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	544					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						CTTGGTGTTCCTTTCCACTCT	0.478000													6	25					0	0	1	0	0
CTAG2	30848	broad.mit.edu	37	X	153881735	153881735	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153881735C>T	ENST00000247306.4	-	1	118	c.55G>A	c.(55-57)Gga>Aga	p.G19R	CTAG2_ENST00000369585.3_Missense_Mutation_p.G19R	NM_020994.3	NP_066274.1	O75638	CTAG2_HUMAN	cancer/testis antigen 2	19	Gly-rich.					centrosome				central_nervous_system(1)|endometrium(1)|lung(6)|ovary(1)|pancreas(1)	10	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCAGGGCCTCCTGGGCCATCA	0.721000													4	7					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33639752	33639752	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33639752C>T	ENST00000361680.2	+	5	693	c.615C>T	c.(613-615)ttC>ttT	p.F205F	WDR88_ENST00000355868.3_Silent_p.F205F			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	205								p.F205F(1)		breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					TCTCAGGCTTCGACGTGGATC	0.493000													61	161					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454371	84454371	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:84454371G>A	ENST00000377084.2	-	1	2157	c.1272C>T	c.(1270-1272)gaC>gaT	p.D424D		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	424						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCCACCTGAGGTCCAAAAGGT	0.468000													28	260					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70418945	70418945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70418945G>A	ENST00000381280.4	+	2	443	c.190G>A	c.(190-192)Gag>Aag	p.E64K	SMOC1_ENST00000361956.3_Missense_Mutation_p.E64K|SMOC1_ENST00000555917.1_3'UTR	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	64	Kazal-like.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		CAGGTCCTACGAGTCCATGTG	0.577000													41	108					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142586786	142586786	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:142586786C>T	ENST00000378004.3	+	21	2367	c.2012C>T	c.(2011-2013)tCa>tTa	p.S671L	ARHGAP26_ENST00000274498.4_Missense_Mutation_p.S671L|ARHGAP26_ENST00000486650.1_Intron	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	671	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCCCAACTTCACCCCTCTCG	0.592000													33	114					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70017060	70017060	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70017060G>A	ENST00000355303.5	+	22	2570	c.2265G>A	c.(2263-2265)ctG>ctA	p.L755L	ANO1_ENST00000538023.1_Silent_p.L755L|ANO1_ENST00000531349.1_Silent_p.L464L|ANO1_ENST00000398543.2_Silent_p.L609L|ANO1_ENST00000525494.1_3'UTR|ANO1_ENST00000530676.1_Silent_p.L609L	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	755					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TTGCGCTGCTGAACAACATCA	0.582000													4	19					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114636424	114636424	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:114636424C>T	ENST00000393296.1	-	7	1594	c.1515_splice	c.e7-1	p.G506_splice	SYT6_ENST00000369547.1_Splice_Site_p.G421_splice			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	506	Necessary for cell membrane association (isoform 2) (By similarity).				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCGAGGGTTTCCCTGGTGAAA	0.458000													6	67					0	0	1	0	0
HTATIP2	10553	broad.mit.edu	37	11	20403763	20403763	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:20403763C>T	ENST00000451739.2	+	4	922	c.481C>T	c.(481-483)Cgt>Tgt	p.R161C	HTATIP2_ENST00000421577.2_Missense_Mutation_p.R161C|HTATIP2_ENST00000443524.2_Missense_Mutation_p.R161C|HTATIP2_ENST00000419348.2_Missense_Mutation_p.R195C|HTATIP2_ENST00000531058.1_Missense_Mutation_p.R115C	NM_001098522.1	NP_001091992.1	Q9BUP3	HTAI2_HUMAN	HIV-1 Tat interactive protein 2, 30kDa	161					angiogenesis|anti-apoptosis|apoptosis|cell differentiation|cellular amino acid metabolic process|induction of apoptosis|interspecies interaction between organisms|nuclear import|regulation of angiogenesis|regulation of transcription from RNA polymerase II promoter	cytoplasm|nuclear envelope	NAD binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|protein binding|transcription coactivator activity			large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						AAAATTTGATCGTTACTCTGT	0.343000													25	53					0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223201	35223201	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:35223201C>T	ENST00000338513.1	+	2	443	c.270C>T	c.(268-270)ctC>ctT	p.L90L		NM_005268.3	NP_005259.1	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	90					cell communication|epidermis development	connexon complex|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				CCTCACTGCTCGTGGTCATGC	0.617000													18	77					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141334096	141334096	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141334096G>A	ENST00000325617.5	-	2	577	c.137C>T	c.(136-138)tCc>tTc	p.S46F	CLGN_ENST00000414773.1_Missense_Mutation_p.S46F|CLGN_ENST00000537281.1_Missense_Mutation_p.S46F	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	46					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					TACCTCTGAGGAAAGTTCACT	0.318000													17	41					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11631189	11631189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11631189G>A	ENST00000262442.3	+	28	5832	c.5764G>A	c.(5764-5766)Gat>Aat	p.D1922N	DNAH9_ENST00000454412.2_Missense_Mutation_p.D1922N	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1922	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGGCTGCTTTGATGAGTTTAA	0.488000													21	23					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51923199	51923199	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:51923199C>T	ENST00000371117.3	-	16	1709	c.1434G>A	c.(1432-1434)ctG>ctA	p.L478L	PKHD1_ENST00000340994.4_Silent_p.L478L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	478					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CATCAGGATTCAGCCAGGTGT	0.552000													40	101					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26242165	26242165	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26242165G>A	ENST00000335473.7	+	19	3717	c.3467G>A	c.(3466-3468)aGg>aAg	p.R1156K	MYO18B_ENST00000536101.1_Missense_Mutation_p.R1156K|MYO18B_ENST00000407587.2_Missense_Mutation_p.R1157K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1156	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GCCCTGCAGAGGAGCCGCATG	0.667000													15	26					0	0	1	0	0
SYNE3	161176	broad.mit.edu	37	14	95921884	95921884	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:95921884G>A	ENST00000334258.5	-	5	981	c.967C>T	c.(967-969)Ctg>Ttg	p.L323L	SYNE3_ENST00000557275.1_Silent_p.L323L|SYNE3_ENST00000554873.1_Silent_p.L80L|SYNE3_ENST00000553340.1_Silent_p.L323L	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						AGGCCCCGCAGCCGCTCCTCC	0.622000													41	114					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276647	152276647	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152276647C>T	ENST00000368799.1	-	3	10750	c.10715G>A	c.(10714-10716)aGa>aAa	p.R3572K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3572	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGCCATCTCTTGACTGCTC	0.557000									Ichthyosis				33	455					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57685473	57685473	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:57685473C>T	ENST00000562631.1	+	3	958	c.426C>T	c.(424-426)tcC>tcT	p.S142S	GPR56_ENST00000568909.1_Silent_p.S142S|GPR56_ENST00000567835.1_Silent_p.S142S|GPR56_ENST00000538815.1_Silent_p.S142S|GPR56_ENST00000456916.1_Silent_p.S142S|GPR56_ENST00000388812.4_Silent_p.S142S|GPR56_ENST00000379696.3_Silent_p.S142S|GPR56_ENST00000379694.4_Intron|GPR56_ENST00000564912.1_3'UTR|GPR56_ENST00000540164.2_Silent_p.S142S|GPR56_ENST00000388813.5_Silent_p.S142S|GPR56_ENST00000562558.1_Silent_p.S142S|GPR56_ENST00000544297.1_5'UTR|GPR56_ENST00000568908.1_Silent_p.S142S			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	142					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						CTGTCACCTCCTGGTGGAGCC	0.602000													8	49					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148055131	148055131	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:148055131T>A	ENST00000370460.2	+	16	3877	c.3398T>A	c.(3397-3399)cTc>cAc	p.L1133H	AFF2_ENST00000370457.5_Missense_Mutation_p.L1098H|AFF2_ENST00000342251.3_Missense_Mutation_p.L1100H|AFF2_ENST00000286437.5_Missense_Mutation_p.L774H	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	1133					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					ACTGTGGAGCTCCTCAGGTGA	0.438000													16	20					0	0	1	0	0
CHRNB3	1142	broad.mit.edu	37	8	42587021	42587021	+	Missense_Mutation	SNP	G	G	A	rs78866303	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42587021G>A	ENST00000289957.2	+	5	699	c.571G>A	c.(571-573)Gac>Aac	p.D191N		NM_000749.3	NP_000740.1	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta 3 (neuronal)	191					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			endometrium(4)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TGAAAATGTCGACAGAAAAGA	0.463000													16	70					0	0	1	0	0
CTAG2	30848	broad.mit.edu	37	X	153880692	153880692	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153880692C>T	ENST00000247306.4	-	2	546	c.483G>A	c.(481-483)gaG>gaA	p.E161E	CTAG2_ENST00000369585.3_Intron	NM_020994.3	NP_066274.1	O75638	CTAG2_HUMAN	cancer/testis antigen 2	161						centrosome				central_nervous_system(1)|endometrium(1)|lung(6)|ovary(1)|pancreas(1)	10	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTTTCTGCCCCTCCGGGGAGG	0.627000													49	48					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57602219	57602219	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57602219T>C	ENST00000371236.2	-	4	566	c.303A>G	c.(301-303)acA>acG	p.T101T	DAB1_ENST00000371231.1_Silent_p.T101T|DAB1_ENST00000439789.2_Silent_p.T101T|DAB1_ENST00000371234.4_Silent_p.T101T|DAB1_ENST00000420954.2_Silent_p.T101T|DAB1_ENST00000371230.1_Silent_p.T101T|DAB1_ENST00000414851.2_Silent_p.T101T|DAB1_ENST00000485760.1_5'UTR			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	101	PID.				cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						TACTTACCCCTGTCTTCTCAT	0.408000													8	53					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891895	5891895	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:5891895G>A	ENST00000581347.1	-	3	813	c.168C>T	c.(166-168)gcC>gcT	p.A56A	TMEM200C_ENST00000383490.2_Silent_p.A56A|RP11-945C19.4_ENST00000577694.1_RNA			A6NKL6	T200C_HUMAN	transmembrane protein 200C	56						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						TCCCACAGAGGGCGATGAGCC	0.622000													9	30					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6678411	6678411	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:6678411G>A	ENST00000245907.6	-	39	4778	c.4686C>T	c.(4684-4686)atC>atT	p.I1562I	C3_ENST00000599668.1_5'UTR	NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1562	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CAATGGCCATGATGTACTCGT	0.577000													11	26					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47173598	47173598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:47173598C>T	ENST00000447411.1	-	8	829	c.623G>A	c.(622-624)gGa>gAa	p.G208E	SLC38A4_ENST00000266579.4_Missense_Mutation_p.G208E	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	208					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					AAGAATAATTCCAACAGACAC	0.303000													17	48					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71036318	71036318	+	Silent	SNP	C	C	T	rs144325682		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:71036318C>T	ENST00000333538.5	+	6	1645	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	337	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGAAGTTCTTCGGTGAAATTG	0.507000													29	87					0	0	1	0	0
ZNF518B	85460	broad.mit.edu	37	4	10447742	10447742	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:10447742G>A	ENST00000326756.3	-	3	649	c.211C>T	c.(211-213)Ctt>Ttt	p.L71F		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						AAATCTTGAAGAGAGATCTTG	0.463000													53	151					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15928546	15928546	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:15928546C>T	ENST00000504595.1	+	3	1156	c.675C>T	c.(673-675)atC>atT	p.I225I	FBXL7_ENST00000329673.7_Silent_p.I213I|FBXL7_ENST00000510662.1_Silent_p.I178I	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	225					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GTTACAATATCTCCAACGAGG	0.582000													18	59					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107865087	107865087	+	Missense_Mutation	SNP	G	G	A	rs104886363		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:107865087G>A	ENST00000328300.6	+	32	2976	c.2732G>A	c.(2731-2733)gGa>gAa	p.G911E	COL4A5_ENST00000361603.2_Missense_Mutation_p.G911E	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	911	Triple-helical region.		G -> E (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						GGACCTTTGGGAATTCCTGGC	0.423000									Alport syndrome with Diffuse Leiomyomatosis				6	13					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599804	29599804	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29599804G>A	ENST00000431530.3	+	1	1057	c.999G>A	c.(997-999)gaG>gaA	p.E333E		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	323						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						TTGAACAGGAGGGAAAGGCAG	0.532000													13	37					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60485496	60485496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60485496G>A	ENST00000360469.5	+	9	1295	c.1207G>A	c.(1207-1209)Gaa>Aaa	p.E403K	CDH4_ENST00000543233.1_Missense_Mutation_p.E329K	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	403	Cadherin 3.				adherens junction organization|cell junction assembly		calcium ion binding	p.E403K(1)		NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GGAGGTCCCCGAAAACCGCGT	0.522000													16	35					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25023490	25023490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25023490C>T	ENST00000400382.1	+	12	1867	c.1112C>T	c.(1111-1113)cCc>cTc	p.P371L	GGT1_ENST00000403838.1_Missense_Mutation_p.P27L|GGT1_ENST00000404223.1_Missense_Mutation_p.P27L|GGT1_ENST00000400383.1_Missense_Mutation_p.P371L|GGT1_ENST00000248923.4_Missense_Mutation_p.P371L|GGT1_ENST00000406383.2_Missense_Mutation_p.P371L|GGT1_ENST00000404920.1_Missense_Mutation_p.P27L|GGT1_ENST00000400380.1_Missense_Mutation_p.P371L|GGT1_ENST00000404532.1_Missense_Mutation_p.P27L|GGT1_ENST00000401885.1_Missense_Mutation_p.P27L|GGT1_ENST00000466310.1_3'UTR			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	371					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	TACTACAAGCCCGAGTTCTAC	0.617000													17	25					0	0	1	0	0
SPRY4	81848	broad.mit.edu	37	5	141694698	141694698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:141694698G>A	ENST00000344120.4	-	3	231	c.45C>T	c.(43-45)tcC>tcT	p.S15S	SPRY4_ENST00000434127.2_5'UTR|SPRY4_ENST00000503582.1_5'UTR	NM_030964.3	NP_112226.2	Q9C004	SPY4_HUMAN	sprouty homolog 4 (Drosophila)	0					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(1)	18		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACTGTACGGAGAAACAGG	0.612000									Testicular Cancer, Familial Clustering of				6	21					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640680	104640680	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104640680G>A	ENST00000304883.2	-	1	293	c.153C>T	c.(151-153)ctC>ctT	p.L51L		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	51						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGGAGGAGGAGAGGTTGCCAG	0.697000													26	42					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55202068	55202068	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:55202068C>A	ENST00000396834.1	+	11	1643	c.1147C>A	c.(1147-1149)Ctt>Att	p.L383I	IL31RA_ENST00000297015.3_Missense_Mutation_p.L260I|IL31RA_ENST00000396836.2_Missense_Mutation_p.L402I|IL31RA_ENST00000354961.4_Missense_Mutation_p.L383I|IL31RA_ENST00000447346.2_Missense_Mutation_p.L402I|IL31RA_ENST00000359040.5_Missense_Mutation_p.L402I|IL31RA_ENST00000490985.1_Missense_Mutation_p.L260I	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	370	Fibronectin type-III 4.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GCCCACCACCCTTTCCTGGGA	0.537000													19	46					2.70639e-06	2.71207e-06	1	1	0
COL5A3	50509	broad.mit.edu	37	19	10077009	10077009	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10077009G>A	ENST00000264828.3	-	64	4848	c.4763C>T	c.(4762-4764)cCc>cTc	p.P1588L		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1588	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CTTCTTGTCGGGATAGAGGCA	0.592000													20	43					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73096880	73096880	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73096880C>T	ENST00000450736.2	+	4	1537	c.1122C>T	c.(1120-1122)ggC>ggT	p.G374G	SLC16A5_ENST00000538213.2_Silent_p.G414G|SLC16A5_ENST00000329783.4_Silent_p.G374G|SLC16A5_ENST00000580123.1_Silent_p.G374G			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	374					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	TCCTGGACGGCCTTGCTTTCC	0.592000													11	11					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34698120	34698120	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34698120T>A	ENST00000360581.1	+	1	224	c.96T>A	c.(94-96)ttT>ttA	p.F32L	NPSR1-AS1_ENST00000419766.1_RNA|NPSR1_ENST00000465305.1_Missense_Mutation_p.F32L|NPSR1_ENST00000381542.1_Missense_Mutation_p.F32L|NPSR1_ENST00000381539.3_Missense_Mutation_p.F32L|NPSR1_ENST00000359791.1_Missense_Mutation_p.F32L|AC005493.1_ENST00000399077.1_Intron|NPSR1_ENST00000381553.3_Missense_Mutation_p.F32L|NPSR1_ENST00000531252.1_Missense_Mutation_p.F32L	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	32						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CAGTGACTTTTACTGAAGTGG	0.498000													20	71					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8175746	8175746	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8175746C>T	ENST00000600128.1	-	34	4730	c.4316G>A	c.(4315-4317)gGg>gAg	p.G1439E	FBN3_ENST00000601739.1_Missense_Mutation_p.G1439E|FBN3_ENST00000270509.2_Missense_Mutation_p.G1439E			Q75N90	FBN3_HUMAN	fibrillin 3	1439	EGF-like 22; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTTGCCACCCCCTCGGTCCAG	0.602000													10	144					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216288081	216288081	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:216288081G>A	ENST00000354785.4	-	9	1754	c.1385C>T	c.(1384-1386)cCc>cTc	p.P462L	FN1_ENST00000421182.1_Missense_Mutation_p.P462L|FN1_ENST00000446046.1_Missense_Mutation_p.P462L|FN1_ENST00000359671.1_Missense_Mutation_p.P462L|FN1_ENST00000357867.4_Missense_Mutation_p.P462L|FN1_ENST00000357009.2_Missense_Mutation_p.P462L|FN1_ENST00000356005.4_Missense_Mutation_p.P462L|FN1_ENST00000346544.3_Missense_Mutation_p.P462L|FN1_ENST00000443816.1_Missense_Mutation_p.P462L|FN1_ENST00000336916.4_Missense_Mutation_p.P462L|FN1_ENST00000323926.6_Missense_Mutation_p.P462L|FN1_ENST00000432072.2_Missense_Mutation_p.P462L|FN1_ENST00000426059.1_Missense_Mutation_p.P462L|FN1_ENST00000345488.5_Missense_Mutation_p.P462L			P02751	FINC_HUMAN	fibronectin 1	462	Collagen-binding.|Fibronectin type-II 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCAGCCATGGGGCAGAACCC	0.458000													34	54					0	0	1	0	0
MPP3	4356	broad.mit.edu	37	17	41907410	41907410	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:41907410G>A	ENST00000398393.1	-	4	623	c.363C>T	c.(361-363)tcC>tcT	p.S121S	MPP3_ENST00000398389.4_Silent_p.S96S			Q13368	MPP3_HUMAN	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	96					signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		GGTGCGGGGTGGACAGCAGCT	0.637000													10	23					0	0	1	0	0
ABLIM1	3983	broad.mit.edu	37	10	116205144	116205144	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116205144C>T	ENST00000369252.4	-	16	1875	c.1574G>A	c.(1573-1575)aGa>aAa	p.R525K	ABLIM1_ENST00000369266.3_Missense_Mutation_p.R262K|ABLIM1_ENST00000277895.5_Missense_Mutation_p.R585K|ABLIM1_ENST00000369253.2_Missense_Mutation_p.R208K|ABLIM1_ENST00000533213.2_Missense_Mutation_p.R525K|ABLIM1_ENST00000392952.3_Missense_Mutation_p.R262K	NM_001003407.1|NM_001003408.1	NP_001003407.1|NP_001003408.1	O14639	ABLM1_HUMAN	actin binding LIM protein 1	585					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		GCCACTAGATCTGCGTTTCAT	0.458000													61	135					0	0	1	0	0
ZNF224	7767	broad.mit.edu	37	19	44610887	44610887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44610887C>T	ENST00000336976.6	+	6	828	c.574C>T	c.(574-576)Cgt>Tgt	p.R192C	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	192					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				CTCAGCCCTTCGTATTCATCA	0.413000													27	248					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60499180	60499180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:60499180G>A	ENST00000371201.3	-	7	1104	c.997C>T	c.(997-999)Cgc>Tgc	p.R333C	C1orf87_ENST00000450089.2_Intron	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	333							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GAGAACGAGCGATCTTCTTTT	0.433000													28	112					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103090189	103090189	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:103090189G>A	ENST00000374902.4	-	8	1857	c.1681C>T	c.(1681-1683)Cat>Tat	p.H561Y	TEX10_ENST00000535814.1_Missense_Mutation_p.H564Y	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	561						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		GAGCCAAGATGAGCAAGTTGC	0.403000													19	38					0	0	1	0	0
APOBEC3G	60489	broad.mit.edu	37	22	39477000	39477000	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39477000G>A	ENST00000407997.3	+	3	591	c.234G>A	c.(232-234)agG>agA	p.R78R	APOBEC3G_ENST00000461827.1_3'UTR|APOBEC3G_ENST00000452957.2_Silent_p.R78R	NM_021822.3	NP_068594.1			apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G											central_nervous_system(1)|large_intestine(4)|lung(5)|skin(1)|stomach(1)	12	Melanoma(58;0.04)					GCAAGTGGAGGAAGCTGCATC	0.552000													23	40					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79069905	79069905	+	Missense_Mutation	SNP	C	C	T	rs148218299	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79069905C>T	ENST00000388820.4	-	9	1558	c.1348G>A	c.(1348-1350)Gac>Aac	p.D450N	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	450	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCAGGAGGGTCGTCCAGGCAC	0.652000													14	7					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50295082	50295082	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:50295082C>T	ENST00000320634.3	-	2	136	c.42G>A	c.(40-42)ggG>ggA	p.G14G	FAIM2_ENST00000550890.1_5'UTR	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	14					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						GCCCCTCGGTCCCAGGGGCCT	0.607000													15	60					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110857886	110857886	+	Splice_Site	SNP	C	C	T	rs111267529		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110857886C>T	ENST00000375820.4	-	16	980		c.e16-1		COL4A1_ENST00000543140.1_Splice_Site	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1						angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CGGGTTTGCCCTGTAGAATAA	0.483000													41	175					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146807044	146807044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:146807044G>A	ENST00000508784.1	-	4	1760	c.1533C>T	c.(1531-1533)agC>agT	p.S511S	ZNF827_ENST00000513320.1_Silent_p.S161S|ZNF827_ENST00000379448.4_Silent_p.S511S			Q17R98	ZN827_HUMAN	zinc finger protein 827	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					CCCCTCCCTGGCTAGTCCTCT	0.602000													22	54					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	170145770	170145770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:170145770G>A	ENST00000328939.4	+	2	607	c.70G>A	c.(70-72)Gaa>Aaa	p.E24K	KCNIP1_ENST00000434108.1_Missense_Mutation_p.E24K|KCNIP1_ENST00000411494.1_Missense_Mutation_p.E35K|KCNIP1_ENST00000520740.1_5'UTR|KCNIP1_ENST00000390656.4_Missense_Mutation_p.E24K|KCNIP1_ENST00000377360.4_Missense_Mutation_p.E33K	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	35					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATAAGATTGAAGATGAGCT	0.517000													17	22					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35923030	35923030	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:35923030G>A	ENST00000490799.1	-	17	2484	c.2131C>T	c.(2131-2133)Cct>Tct	p.P711S	SLC26A8_ENST00000355574.2_Missense_Mutation_p.P711S|SLC26A8_ENST00000394602.2_Missense_Mutation_p.P606S	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	711	Interaction with RACGAP1.|STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						TCTGAGTAAGGGATGAGTGAT	0.507000													27	63					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160873224	160873224	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160873224C>T	ENST00000283243.7	-	9	1659		c.e9-1		PLA2R1_ENST00000392771.1_Splice_Site	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa						endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						AGTGTCCCTCCTACGGAGAAA	0.378000													17	57					0	0	1	0	0
DENND1B	163486	broad.mit.edu	37	1	197522230	197522230	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197522230G>A	ENST00000235453.4	-	16	1349	c.1072C>T	c.(1072-1074)Cga>Tga	p.R358*	DENND1B_ENST00000367396.3_Nonsense_Mutation_p.R388*|DENND1B_ENST00000400967.2_Nonsense_Mutation_p.R358*			Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B	388	dDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity	p.R358*(1)|p.R388*(1)|p.R28*(1)		NS(2)|breast(2)|kidney(2)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	22						TTTGCCAGTCGACCATCGATA	0.299000													9	75					0	0	1	0	0
LEPREL2	10536	broad.mit.edu	37	12	6946681	6946681	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6946681C>T	ENST00000251761.8	+	0	1688				LEPREL2_ENST00000606935.1_RNA|LEPREL2_ENST00000396725.2_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						TACTTCTCCCCGGAACGGCCC	0.657000													5	14					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51974720	51974720	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:51974720C>T	ENST00000220478.3	+	2	492	c.89C>T	c.(88-90)tCt>tTt	p.S30F	SCG3_ENST00000542355.2_Intron	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	30					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		CTAGACAAATCTCTACATAAT	0.244000													16	37					0	0	1	0	0
FGF21	26291	broad.mit.edu	37	19	49261325	49261325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49261325G>A	ENST00000593756.1	+	4	1050	c.478G>A	c.(478-480)Gga>Aga	p.G160R	FGF21_ENST00000222157.3_Missense_Mutation_p.G160R			Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21	160					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)|cervix(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		TGCACCCCGAGGACCAGCTCG	0.687000													10	48					0	0	1	0	0
ESCO2	157570	broad.mit.edu	37	8	27660931	27660931	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27660931C>T	ENST00000305188.8	+	11	2020	c.1782C>T	c.(1780-1782)ttC>ttT	p.F594F	ESCO2_ENST00000397418.2_Intron	NM_001017420.2	NP_001017420.1	Q56NI9	ESCO2_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 2	594					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		CCCCTAATTTCCTCGTATATA	0.333000									SC Phocomelia syndrome				26	65					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40719134	40719134	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:40719134C>T	ENST00000454349.2	+	23	5602	c.5391C>T	c.(5389-5391)aaC>aaT	p.N1797N	TNRC6B_ENST00000402203.1_Silent_p.N993N|TNRC6B_ENST00000301923.9_Silent_p.N993N|TNRC6B_ENST00000335727.8_Silent_p.N1687N	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1797					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						GGCCCCCAAACTATTCTTCTA	0.607000													9	23					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90281262	90281262	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:90281262G>A	ENST00000405460.2	+	85	18171	c.18075G>A	c.(18073-18075)gtG>gtA	p.V6025V	GPR98_ENST00000425867.2_Silent_p.V1686V	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6025					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTTTGTGGTGATTCTCCTCA	0.438000													8	51					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128342354	128342354	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:128342354G>A	ENST00000389524.4	+	14	1609	c.1554_splice	c.e14-1	p.G519_splice	MYO7B_ENST00000428314.1_Splice_Site_p.G519_splice|MYO7B_ENST00000409816.2_Splice_Site_p.G519_splice			Q6PIF6	MYO7B_HUMAN	myosin VIIB	519	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TTCTTCCAGGGGACAGATCTC	0.567000													31	65					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57358377	57358377	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57358377G>A	ENST00000314922.3	-	1	212	c.136C>T	c.(136-138)Ctg>Ttg	p.L46L	PENK_ENST00000523051.1_Silent_p.L46L|PENK_ENST00000451791.2_Silent_p.L46L|RP11-17A4.2_ENST00000518662.1_RNA|PENK_ENST00000518770.1_Silent_p.L46L	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	46					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			ACACTCACCAGGAAGTTGATG	0.687000													8	91					0	0	1	0	0
OR4D9	390199	broad.mit.edu	37	11	59282416	59282416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59282416G>A	ENST00000329328.3	+	1	31	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						CAGAGTGAAAGAATTTACCTT	0.378000													48	111					0	0	1	0	0
DHRS13	147015	broad.mit.edu	37	17	27225649	27225649	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:27225649G>A	ENST00000394901.3	-	4	1186	c.794C>T	c.(793-795)cCt>cTt	p.P265L	RP11-20B24.4_ENST00000580603.1_RNA|DHRS13_ENST00000426464.2_Missense_Mutation_p.P234L|DHRS13_ENST00000378895.4_Missense_Mutation_p.P315L|RP11-20B24.4_ENST00000579187.1_RNA			Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	315						extracellular region	binding|oxidoreductase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	9	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			ATCCTCCCCAGGCCCAAGCCC	0.627000													8	9					0	0	1	0	0
MFSD2A	84879	broad.mit.edu	37	1	40430940	40430940	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:40430940C>T	ENST00000372809.5	+	4	593	c.450C>T	c.(448-450)ccC>ccT	p.P150P	MFSD2A_ENST00000420632.2_5'UTR|MFSD2A_ENST00000480630.1_3'UTR|MFSD2A_ENST00000372811.5_Silent_p.P137P	NM_001136493.1	NP_001129965.1	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing 2A	150					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						GGTTCGTGCCCGACTTCCCAC	0.567000													6	100					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32821520	32821520	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32821520C>T	ENST00000380250.3	+	48	7385	c.6889C>T	c.(6889-6891)Ctt>Ttt	p.L2297F		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GTCAGCCAGCCTTGTTTTACC	0.408000													36	100					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	108970464	108970464	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:108970464C>T	ENST00000276659.5	-	5	1080	c.460G>A	c.(460-462)Gga>Aga	p.G154R	RSPO2_ENST00000517939.1_Missense_Mutation_p.G87R|RSPO2_ENST00000517781.1_Missense_Mutation_p.G90R|RSPO2_ENST00000378439.2_Missense_Mutation_p.G90R	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	154	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CTACAAGTTCCCCATTCGCTC	0.373000													24	65					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367211	107367211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107367211C>T	ENST00000542196.1	-	1	740	c.698G>A	c.(697-699)gGg>gAg	p.G233E		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						TTTGCTTCTCCCCTCGGAAGA	0.413000													25	68					0	0	1	0	0
TM6SF1	53346	broad.mit.edu	37	15	83784673	83784673	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83784673C>T	ENST00000322019.9	+	3	547	c.273C>T	c.(271-273)ttC>ttT	p.F91F	TM6SF1_ENST00000379386.4_Silent_p.F91F|TM6SF1_ENST00000564988.1_3'UTR|TM6SF1_ENST00000379390.6_Silent_p.F91F|TM6SF1_ENST00000565774.1_Silent_p.F91F			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	91						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						TTGACGGGTTCATGACACACT	0.433000													22	67					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166167070	166167070	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166167070G>T	ENST00000375437.2	+	7	1225	c.935G>T	c.(934-936)aGc>aTc	p.S312I	SCN2A_ENST00000375427.2_Missense_Mutation_p.S312I|SCN2A_ENST00000357398.3_Missense_Mutation_p.S312I|SCN2A_ENST00000283256.6_Missense_Mutation_p.S312I	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	312					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	AGGACAGTGAGCATATTTAAC	0.284000													17	47					5.35267e-07	5.36647e-07	1	1	0
IFNA21	3452	broad.mit.edu	37	9	21166595	21166595	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:21166595G>A	ENST00000380225.1	-	1	64	c.17C>T	c.(16-18)tCt>tTt	p.S6F		NM_002175.2	NP_002166.2	P01568	IFN21_HUMAN	interferon, alpha 21	6					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)	14				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CATCAGTAAAGAAAAGGACAG	0.498000													25	65					0	0	1	0	0
MYLIP	29116	broad.mit.edu	37	6	16141939	16141939	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:16141939C>T	ENST00000356840.3	+	3	560	c.362C>T	c.(361-363)gCc>gTc	p.A121V	MYLIP_ENST00000349606.4_5'UTR	NM_013262.3	NP_037394.2	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting protein	121	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GAACTCAGTGCCCTCCTGGCC	0.537000													34	69					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	769423	769423	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:769423G>A	ENST00000297440.6	+	2	739	c.719G>A	c.(718-720)gGg>gAg	p.G240E	HEATR2_ENST00000313147.5_Missense_Mutation_p.G240E|HEATR2_ENST00000438961.1_3'UTR	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	240							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		TTTGGCAACGGGAAGTCCGTG	0.572000													18	42					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142723973	142723973	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142723973C>T	ENST00000350513.2	-	1	309	c.247G>A	c.(247-249)Gga>Aga	p.G83R		NM_001001658.1	NP_001001658.1	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A, member 2	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(3)|endometrium(4)|large_intestine(1)|lung(14)|skin(3)	25	Melanoma(164;0.059)					AAGAGCAATCCCCAAAGCATC	0.483000													25	55					0	0	1	0	0
OR52E4	390081	broad.mit.edu	37	11	5906301	5906301	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5906301T>A	ENST00000316987.2	+	1	801	c.779T>A	c.(778-780)tTt>tAt	p.F260Y		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTTTTTTCTTTTATGACACAT	0.423000													59	129					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187172751	187172751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187172751C>T	ENST00000264690.6	+	9	1166	c.979C>T	c.(979-981)Cgc>Tgc	p.R327C	KLKB1_ENST00000513864.1_Missense_Mutation_p.R327C	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	327	Apple 4.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		AAAGATGATTCGCTGTCAGTT	0.353000													38	87					0	0	1	0	0
AADACL4	343066	broad.mit.edu	37	1	12725999	12725999	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12725999C>T	ENST00000376221.1	+	4	477	c.477C>T	c.(475-477)tcC>tcT	p.S159S		NM_001013630.1	NP_001013652.1	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	159						integral to membrane	carboxylesterase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)	17	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		ACCACCATTCCCCTGCCCTTT	0.522000													10	103					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124745472	124745472	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124745472C>T	ENST00000397801.1	+	15	2504	c.2312C>T	c.(2311-2313)cCc>cTc	p.P771L	ROBO3_ENST00000538940.1_Missense_Mutation_p.P749L	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	771	Fibronectin type-III 3.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CCCAGTGGCCCCCCACAGGGA	0.612000													6	26					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165984293	165984293	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:165984293C>T	ENST00000360093.3	-	18	3732	c.3241G>A	c.(3241-3243)Gaa>Aaa	p.E1081K	SCN3A_ENST00000409101.3_Missense_Mutation_p.E1032K|SCN3A_ENST00000283254.7_Missense_Mutation_p.E1081K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1081						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ACGTATTTTTCAACACTGCTT	0.393000													24	62					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827110	96827110	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96827110G>A	ENST00000371270.3	-	3	430	c.336C>T	c.(334-336)atC>atT	p.I112I	CYP2C8_ENST00000539050.1_Silent_p.I26I|CYP2C8_ENST00000535898.1_Silent_p.I10I	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	112					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TGCTGGAAATGATTCCTAATA	0.488000													17	51					0	0	1	0	0
TOMM40L	84134	broad.mit.edu	37	1	161196322	161196322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:161196322C>T	ENST00000367988.3	+	2	312	c.43C>T	c.(43-45)Cgc>Tgc	p.R15C	TOMM40L_ENST00000367987.1_Missense_Mutation_p.R15C|TOMM40L_ENST00000545897.1_Missense_Mutation_p.R15C|TOMM40L_ENST00000474486.1_3'UTR	NM_032174.4	NP_115550.2	Q969M1	TM40L_HUMAN	translocase of outer mitochondrial membrane 40 homolog (yeast)-like	15					protein transport	mitochondrial outer membrane|pore complex	porin activity|voltage-gated anion channel activity			large_intestine(2)|liver(4)|lung(4)	10	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			GACTTTGCCCCGCCGGAGCCC	0.602000													12	44					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64331852	64331852	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:64331852G>A	ENST00000301891.4	+	5	1268	c.894G>A	c.(892-894)aaG>aaA	p.K298K	SLC22A11_ENST00000490834.1_Intron|SLC22A11_ENST00000377585.3_Silent_p.K298K|SLC22A11_ENST00000377581.3_Silent_p.K298K	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	298					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	AGCTCAGAAAGGTGGCCAGGA	0.562000													20	49					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35033608	35033608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35033608C>T	ENST00000231420.6	-	6	832	c.632G>A	c.(631-633)gGg>gAg	p.G211E		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	211					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CTTGTAGGTCCCTACGTTTGT	0.483000													18	56					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93615517	93615517	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:93615517G>A	ENST00000394236.3	-	9	1184	c.868C>T	c.(868-870)Ccc>Tcc	p.P290S	PROS1_ENST00000407433.1_Missense_Mutation_p.P159S	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	290					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	AGGTTCAAGGGAAGGCACACT	0.368000													36	166					0	0	1	0	0
TRIM40	135644	broad.mit.edu	37	6	30104940	30104940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:30104940G>A	ENST00000396581.1	+	2	513	c.127G>A	c.(127-129)Gag>Aag	p.E43K	TRIM40_ENST00000489892.1_3'UTR|TRIM40_ENST00000376724.2_Missense_Mutation_p.E43K|TRIM40_ENST00000307859.4_Missense_Mutation_p.E43K			Q6P9F5	TRI40_HUMAN	tripartite motif containing 40	43						intracellular	zinc ion binding			ovary(1)	1						ACAGCATGTGGAGAAGGCCTC	0.612000													16	47					0	0	1	0	0
MRO	83876	broad.mit.edu	37	18	48327813	48327813	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:48327813C>T	ENST00000428869.2	-	7	749	c.491G>A	c.(490-492)gGg>gAg	p.G164E	MRO_ENST00000398439.3_Missense_Mutation_p.G164E|MRO_ENST00000587291.1_5'UTR|MRO_ENST00000431965.2_Intron|MRO_ENST00000436348.2_Missense_Mutation_p.G178E|MRO_ENST00000256425.2_Missense_Mutation_p.G164E|MRO_ENST00000588444.1_Intron			Q9BYG7	MSTRO_HUMAN	maestro	164						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		CCATTTCCTCCCGGCAAAGGC	0.468000													69	134					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49381496	49381496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:49381496G>A	ENST00000406846.2	-	1	180	c.61C>T	c.(61-63)Cgg>Tgg	p.R21W	FSHR_ENST00000304421.4_Missense_Mutation_p.R21W|FSHR_ENST00000346173.3_Missense_Mutation_p.R21W	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	21	LRRNT.				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGACAGATCCGATGATGACAT	0.493000									Gonadal Dysgenesis, 46 XX				18	36					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55652961	55652961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55652961G>A	ENST00000449290.2	+	2	149	c.57G>A	c.(55-57)atG>atA	p.M19I		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	19						intracellular	zinc ion binding										CCATCTGCATGAACTACTTCC	0.502000													41	99					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40979312	40979312	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:40979312G>A	ENST00000373198.3	-	11	2056	c.1821C>T	c.(1819-1821)atC>atT	p.I607I	PTPRT_ENST00000373193.3_Silent_p.I607I|PTPRT_ENST00000373184.1_Silent_p.I607I|PTPRT_ENST00000373201.1_Silent_p.I607I|PTPRT_ENST00000373190.1_Silent_p.I607I|PTPRT_ENST00000373187.1_Silent_p.I607I|PTPRT_ENST00000356100.2_Silent_p.I607I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	607	Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCATCACTGTGATGGTCGTGT	0.532000													44	105					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141007	143141007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143141007C>T	ENST00000332690.1	+	1	462	c.462C>T	c.(460-462)ttC>ttT	p.F154F	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	154					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					TCTCCAGCTTCACCACCATTC	0.463000													66	161					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106124535	106124535	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106124535G>A	ENST00000369704.3	+	4	619	c.485G>A	c.(484-486)aGa>aAa	p.R162K	CCDC147_ENST00000312902.5_5'UTR	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	162										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ACAAAGGAGAGAGACCAGCTC	0.458000													22	60					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42796998	42796998	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42796998C>T	ENST00000572681.2	+	15	6248	c.6180C>T	c.(6178-6180)ttC>ttT	p.F2060F	CIC_ENST00000160740.3_Silent_p.F1151F|CIC_ENST00000575354.2_Silent_p.F1152F			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CTAGCCCTTTCCCCAGCGCCA	0.632000			"""Mis, F, S"""		oligodendroglioma								15	112					0	0	1	0	0
TTLL8	164714	broad.mit.edu	37	22	50488621	50488621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:50488621C>T	ENST00000266182.6	-	2	106	c.107G>A	c.(106-108)cGa>cAa	p.R36Q	TTLL8_ENST00000477219.1_5'UTR|TTLL8_ENST00000440475.1_Missense_Mutation_p.R36Q					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GCCCTTCCTTCGCAGAGCGGC	0.493000													6	14					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793740	17793740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17793740G>A	ENST00000379472.3	+	2	1129	c.1099G>A	c.(1099-1101)Gag>Aag	p.E367K	KCNC1_ENST00000265969.6_Missense_Mutation_p.E367K	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	367						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CTACTACGCCGAGAGGATAGG	0.607000													16	51					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307514	140307514	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140307514C>T	ENST00000253807.2	+	1	1037	c.1037C>T	c.(1036-1038)tCg>tTg	p.S346L	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.S346L|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGACTCTTTCGAACCCAGTA	0.517000													9	147					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109780861	109780861	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:109780861C>T	ENST00000399132.1	-	24	1801	c.1271G>A	c.(1270-1272)gGa>gAa	p.G424E	COL25A1_ENST00000399127.1_Missense_Mutation_p.G405E|COL25A1_ENST00000399126.1_Missense_Mutation_p.G424E	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	424	Collagen-like 5.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTCAGTGGCTCCTTGATCCCC	0.507000													12	35					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065679	55065679	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55065679G>A	ENST00000526016.1	-	0	29					NR_038174.2																						ACTGGGTCTAGGAAGTAGTTC	0.473000													49	93					0	0	1	0	0
ICAM5	7087	broad.mit.edu	37	19	10405169	10405169	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10405169C>T	ENST00000221980.4	+	9	2146	c.2083C>T	c.(2083-2085)Cgc>Tgc	p.R695C		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	695	Ig-like C2-type 8.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CGCCCGGGGTCGCCCTTCCCC	0.677000													9	27					0	0	1	0	0
DRAXIN	374946	broad.mit.edu	37	1	11766499	11766499	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11766499C>T	ENST00000294485.5	+	2	319	c.184C>T	c.(184-186)Ccg>Tcg	p.P62S		NM_198545.3	NP_940947.3			dorsal inhibitory axon guidance protein																		CCGGCGGGGCCCGGGCAAGAA	0.721000													9	15					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52520529	52520529	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:52520529G>A	ENST00000242839.4	-	13	3107	c.2951C>T	c.(2950-2952)cCc>cTc	p.P984L	ATP7B_ENST00000418097.2_Intron|ATP7B_ENST00000344297.5_Missense_Mutation_p.P777L|ATP7B_ENST00000448424.2_Missense_Mutation_p.P906L|ATP7B_ENST00000417240.2_Missense_Mutation_p.P256L|ATP7B_ENST00000400370.3_Missense_Mutation_p.P554L|ATP7B_ENST00000482841.1_5'UTR|ATP7B_ENST00000400366.3_Missense_Mutation_p.P873L	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	984					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CAGGGAGCAGGGGCAGGCAAT	0.622000									Wilson disease				5	36					0	0	1	0	0
ZNF670	93474	broad.mit.edu	37	1	247202116	247202116	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247202116G>A	ENST00000366503.2	-	3	345	c.187C>T	c.(187-189)Cta>Tta	p.L63L		NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			AATTACCTTAGATTTCTCCCA	0.328000													11	59					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6262747	6262747	+	Missense_Mutation	SNP	C	C	T	rs141400949	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6262747C>T	ENST00000379936.2	+	5	1119	c.1004C>T	c.(1003-1005)gCt>gTt	p.A335V	CNGA4_ENST00000533426.1_Missense_Mutation_p.A104V	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	335					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCAGAAGTGGCTGTGTCTGTG	0.577000													37	86					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91811697	91811697	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91811697C>T	ENST00000394232.1	+	9	1705	c.1235C>T	c.(1234-1236)cCt>cTt	p.P412L	SV2B_ENST00000330276.4_Missense_Mutation_p.P412L|SV2B_ENST00000545111.2_Missense_Mutation_p.P261L	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	412					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GTTTGGTTTCCTGATATGATC	0.418000													53	172					0	0	1	0	0
ENTPD2	954	broad.mit.edu	37	9	139945765	139945765	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139945765G>T	ENST00000355097.2	-	4	491	c.444C>A	c.(442-444)acC>acA	p.T148T	ENTPD2_ENST00000312665.5_Silent_p.T148T	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	148						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGGGGTACTGGGTCAGTGTGT	0.582000													24	60					3.73988e-18	3.76221e-18	1	1	0
SLITRK3	22865	broad.mit.edu	37	3	164906683	164906683	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164906683G>A	ENST00000475390.1	-	2	2379	c.1936C>T	c.(1936-1938)Cct>Tct	p.P646S	SLITRK3_ENST00000241274.3_Missense_Mutation_p.P646S			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	646						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CCCCCAGGAGGAGAAAACTCA	0.532000										HNSCC(40;0.11)			10	27					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26802488	26802488	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26802488G>A	ENST00000376236.4	+	8	1167	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	238	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						TGAAGACCATGAAAATGTTGT	0.338000													25	58					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134179613	134179613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:134179613G>A	ENST00000431683.2	+	11	1055	c.1055G>A	c.(1054-1056)gGg>gAg	p.G352E		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	352					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TTCATGAACGGGGCCACATAT	0.483000													6	18					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129664305	129664305	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:129664305G>A	ENST00000358303.4	-	7	902	c.818C>T	c.(817-819)tCg>tTg	p.S273L	ZC3HC1_ENST00000360708.5_Missense_Mutation_p.S273L|RP11-306G20.1_ENST00000480018.1_RNA|ZC3HC1_ENST00000481503.1_Intron|ZC3HC1_ENST00000311873.5_Missense_Mutation_p.S252L|RP11-306G20.1_ENST00000587038.1_RNA	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	273					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					CATACATTGCGAACATGTTAT	0.468000													17	33					0	0	1	0	0
CHST13	166012	broad.mit.edu	37	3	126261284	126261284	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126261284G>A	ENST00000319340.2	+	3	939	c.889G>A	c.(889-891)Gcc>Acc	p.A297T		NM_152889.2	NP_690849.1	Q8NET6	CHSTD_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 13	297					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			central_nervous_system(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(114;0.151)		gccccggggagccgccgccTC	0.706000													4	8					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129276019	129276019	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129276019G>A	ENST00000324093.4	-	34	5671	c.5493C>T	c.(5491-5493)taC>taT	p.Y1831Y	PLXND1_ENST00000504689.1_5'UTR|PLXND1_ENST00000393239.1_3'UTR	NM_015103.2	NP_055918.2	Q9Y4D7	PLXD1_HUMAN	plexin D1	1831					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CGATCTTCCGGTACTCAGGAA	0.572000													29	72					0	0	1	0	0
LMO3	55885	broad.mit.edu	37	12	16757809	16757809	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:16757809C>T	ENST00000261169.6	-	1	272	c.15G>A	c.(13-15)gaG>gaA	p.E5E	LMO3_ENST00000535535.1_Intron|LMO3_ENST00000447609.1_Intron|LMO3_ENST00000320122.6_5'UTR|LMO3_ENST00000354662.1_Intron|LMO3_ENST00000537568.1_Intron|LMO3_ENST00000540848.1_Intron|LMO3_ENST00000441439.2_Intron|LMO3_ENST00000534946.1_Intron|LMO3_ENST00000541846.1_Intron|LMO3_ENST00000540445.1_Intron|LMO3_ENST00000537304.1_Intron|LMO3_ENST00000541295.1_Intron			Q8TAP4	LMO3_HUMAN	LIM domain only 3 (rhombotin-like 2)	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent		zinc ion binding			endometrium(2)|large_intestine(2)|skin(1)	5		Hepatocellular(102;0.244)				CAAAACTTTTCTCCTTTTTCT	0.478000													34	92					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566086	5566086	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5566086G>A	ENST00000322653.4	-	1	693	c.668C>T	c.(667-669)gCt>gTt	p.A223V	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTAGGAAACAGCAATGAGAAT	0.507000													21	41					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71825460	71825460	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:71825460G>A	ENST00000373545.3	-	23	2877	c.2439C>T	c.(2437-2439)ccC>ccT	p.P813P	PHKA1_ENST00000373539.3_Silent_p.P872P|PHKA1_ENST00000339490.3_Silent_p.P872P|PHKA1_ENST00000373542.4_Silent_p.P872P|PHKA1_ENST00000541944.1_Silent_p.P813P			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	872	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					GCGCCTCATAGGGCAGAGGTC	0.388000													15	17					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170720368	170720368	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:170720368G>A	ENST00000314251.3	-	8	1144	c.1065C>T	c.(1063-1065)gtC>gtT	p.V355V	SLC2A2_ENST00000382808.4_Silent_p.V236V	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	355					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GACTTACAGAGACAGCAGTGA	0.428000													12	32					0	0	1	0	0
F12	2161	broad.mit.edu	37	5	176831610	176831610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176831610C>T	ENST00000253496.3	-	8	738	c.690G>A	c.(688-690)agG>agA	p.R230R		NM_000505.3	NP_000496.2	P00748	FA12_HUMAN	coagulation factor XII (Hageman factor)	230	Kringle.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAGCGTGGTCCTGGCCAGGC	0.701000									Hereditary Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	12					0	0	1	0	0
OR8K1	390157	broad.mit.edu	37	11	56114291	56114291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56114291G>A	ENST00000279783.2	+	1	871	c.777G>A	c.(775-777)ggG>ggA	p.G259G		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TGTTCTATGGGACATTGTTAT	0.408000										HNSCC(65;0.19)			12	90					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718804	140718804	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140718804G>A	ENST00000394576.2	+	1	266	c.266G>A	c.(265-267)aGg>aAg	p.R89K	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCGAACAGGATAGACCGG	0.547000													20	103					0	0	1	0	0
IGLV3-19	28797	broad.mit.edu	37	22	23063518	23063518	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:23063518G>A	ENST00000390309.2	+	0	265																											GGCCCTCAGGGATCCCAGACC	0.532000													23	53					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101748028	101748028	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:101748028C>T	ENST00000251127.6	-	28	3247	c.3166G>A	c.(3166-3168)Gat>Aat	p.D1056N		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1056						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCATTGCAATCTTCCTAAAGT	0.388000													21	60					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23208684	23208684	+	Missense_Mutation	SNP	C	C	T	rs141248272		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23208684C>T	ENST00000300061.2	+	6	1156	c.1013C>T	c.(1012-1014)cCc>cTc	p.P338L	CTC-391G2.1_ENST00000563471.1_RNA	NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	338					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding	p.P338L(1)		NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GATGAGTATCCCTTCGTCGAA	0.468000													12	56					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684479	100684479	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100684479C>T	ENST00000306151.4	+	3	9846	c.9782C>T	c.(9781-9783)tCa>tTa	p.S3261L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3261	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCAGTTCATCTCCTCCC	0.527000													214	469					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105920842	105920842	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105920842C>T	ENST00000357060.3	-	27	3608	c.3493G>A	c.(3493-3495)Gag>Aag	p.E1165K	WDR96_ENST00000428666.1_Missense_Mutation_p.E1166K	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1165										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						ACTTTTTTCTCATAATCTTTG	0.333000													12	33					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267481	71267481	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:71267481G>A	ENST00000554752.2	-	2	722	c.723C>T	c.(721-723)atC>atT	p.I241I	MAP3K9_ENST00000555993.2_Silent_p.I241I|MAP3K9_ENST00000381250.4_Silent_p.I241I			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	241	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		AATTCACCAGGATGTCTGGGG	0.502000													13	89					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45295394	45295394	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:45295394G>A	ENST00000447098.2	-	8	986	c.975C>T	c.(973-975)ccC>ccT	p.P325P	PTCH2_ENST00000372192.3_Silent_p.P325P	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	325					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					ACAGCTGGCGGGGACTCATCA	0.617000									Basal Cell Nevus syndrome				24	51					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	192053205	192053205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:192053205C>T	ENST00000454309.2	-	3	1184	c.359G>A	c.(358-360)gGa>gAa	p.G120E	FGF12_ENST00000264730.3_Missense_Mutation_p.G58E|FGF12_ENST00000445105.1_Missense_Mutation_p.G58E|FGF12_ENST00000430714.1_Missense_Mutation_p.G21E|FGF12_ENST00000450716.1_Missense_Mutation_p.G58E	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	120					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		AGCCTTCACTCCTTGGATGGC	0.458000													33	84					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538598	4538598	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4538598G>A	ENST00000306390.6	-	2	858	c.398C>T	c.(397-399)cCg>cTg	p.P133L	LRG1_ENST00000586883.1_5'UTR|CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	133			P -> S (in dbSNP:rs966384).			extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGAGGCCCGGGGGCAGCCC	0.632000													23	46					0	0	1	0	0
TRBV6-1	28606	broad.mit.edu	37	7	142028450	142028450	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142028450C>T	ENST00000390353.2	+	0	241																											AGGCATGGGACTGAGGCTGAT	0.488000													45	190					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63141473	63141473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63141473G>A	ENST00000279178.3	+	4	1018	c.769G>A	c.(769-771)Gac>Aac	p.D257N	SLC22A9_ENST00000310969.4_Missense_Mutation_p.R205K	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	257					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						TGCCATTCGAGACTGGCATAT	0.458000													8	39					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7723933	7723933	+	Silent	SNP	C	C	T	rs141193119		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:7723933C>T	ENST00000303635.7	+	9	1533	c.1326C>T	c.(1324-1326)ttC>ttT	p.F442F	CAMTA1_ENST00000439411.2_Silent_p.F442F	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	442					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCCACAAGTTCGCCTTTCCCA	0.652000			T	WWTR1	epitheliod hemangioendothelioma								21	59					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322479	55322479	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55322479G>A	ENST00000314644.2	+	1	697	c.697G>A	c.(697-699)Gac>Aac	p.D233N		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CTTTATGTGTGACTTGTACCC	0.458000										HNSCC(20;0.049)			10	40					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3211823	3211823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3211823G>A	ENST00000380059.3	-	9	1244	c.1143C>T	c.(1141-1143)ttC>ttT	p.F381F	SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Silent_p.F338F|SLC4A11_ENST00000380056.3_Silent_p.F354F	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	354	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						GGTACAAGGGGAACCTGCGTG	0.602000													41	145					0	0	1	0	0
SHF	90525	broad.mit.edu	37	15	45491118	45491118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:45491118G>A	ENST00000290894.8	-	2	649	c.155C>T	c.(154-156)cCc>cTc	p.P52L	SHF_ENST00000318390.6_Missense_Mutation_p.P109L|CTD-2651B20.7_ENST00000568314.1_RNA|RP11-519G16.2_ENST00000560034.1_RNA	NM_138356.2	NP_612365.2	B3KTY1	B3KTY1_HUMAN	Src homology 2 domain containing F	52										endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(2)	12		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		GGAGTTTAGGGGAGACGGCGT	0.602000											OREG0023105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	37					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046763	73046763	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:73046763C>T	ENST00000604411.1	+	0	34724				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AGCCTTGAGACTTCCATCCAA	0.488000													27	19					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87040294	87040294	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87040294G>A	ENST00000370563.3	+	10	1581	c.1539G>A	c.(1537-1539)gtG>gtA	p.V513V	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	513						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		ATAGTACAGTGGGAAAGGACA	0.393000													26	63					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49699234	49699234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:49699234C>T	ENST00000303221.5	-	6	870	c.655G>A	c.(655-657)Gaa>Aaa	p.E219K	EMB_ENST00000508934.1_Missense_Mutation_p.E165K|EMB_ENST00000514111.1_Missense_Mutation_p.E169K|EMB_ENST00000506190.1_5'UTR	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	219	Ig-like V-type 2.					integral to membrane		p.E219K(1)		breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				AGCTTTGTTTCGTTAGCATAT	0.378000													10	65					0	0	1	0	0
RAD54L	8438	broad.mit.edu	37	1	46733247	46733247	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:46733247C>T	ENST00000371975.4	+	9	1682	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	RAD54L_ENST00000442598.1_Silent_p.F336F	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	336	Helicase ATP-binding.				meiosis	nucleus	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		TTGAGTATTTCAGCTTGGTAC	0.493000								Direct reversal of damage;Homologous recombination					31	49					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50813008	50813008	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50813008C>T	ENST00000440075.2	+	43	6119	c.6072C>T	c.(6070-6072)tcC>tcT	p.S2024S	MYH14_ENST00000425460.1_Silent_p.S1991S|MYH14_ENST00000376970.2_Silent_p.S2016S|MYH14_ENST00000598205.1_Silent_p.S1991S|MYH14_ENST00000596571.1_Silent_p.S1983S|MYH14_ENST00000262269.8_Silent_p.S2024S|MYH14_ENST00000601313.1_Silent_p.S2024S			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1983					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CTGGGCCATCCCCGGAGCCTG	0.682000													5	5					0	0	1	0	0
FCGRT	2217	broad.mit.edu	37	19	50017667	50017667	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50017667C>T	ENST00000221466.5	+	4	1011	c.525C>T	c.(523-525)ctC>ctT	p.L175L	FCGRT_ENST00000599988.1_Intron|FCGRT_ENST00000596975.1_Intron|FCGRT_ENST00000594823.1_3'UTR|FCGRT_ENST00000426395.3_Silent_p.L175L	NM_001136019.2	NP_001129491.1	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	175	Alpha-2.				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			endometrium(3)|kidney(2)|lung(1)|ovary(1)|prostate(1)|skin(1)	9		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		ACAAGGAGCTCACCTTCCTGC	0.667000													7	28					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219888004	219888004	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219888004C>T	ENST00000341552.5	-	16	2828	c.2745G>A	c.(2743-2745)tgG>tgA	p.W915*	CCDC108_ENST00000441968.1_Nonsense_Mutation_p.W915*|CCDC108_ENST00000453220.1_Nonsense_Mutation_p.W915*	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	915	MSP.					integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGAGACCCTCCACTCGAACT	0.632000													5	20					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88119601	88119601	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:88119601G>A	ENST00000507897.1	+	2	127	c.44G>A	c.(43-45)cGa>cAa	p.R15Q	C6ORF165_ENST00000369562.4_Missense_Mutation_p.R15Q			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	15										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGTATTATACGAGAAATAGGA	0.318000													8	89					0	0	1	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473014	22473014	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22473014C>T	ENST00000557788.2	-	0	256																											TATGGTGACTCGACTCTTGAG	0.577000													40	375					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122261582	122261582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122261582C>T	ENST00000334010.7	-	5	1478	c.1057G>A	c.(1057-1059)Gag>Aag	p.E353K	CADPS2_ENST00000449022.2_Missense_Mutation_p.E353K|CADPS2_ENST00000313070.7_Missense_Mutation_p.E353K|CADPS2_ENST00000412584.2_Missense_Mutation_p.E353K	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	353					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						AGCTGAATCTCATTCTCATCT	0.393000													34	104					0	0	1	0	0
CCL15	6359	broad.mit.edu	37	17	34328476	34328476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34328476G>A	ENST00000354059.4	-	1	608	c.56C>T	c.(55-57)tCc>tTc	p.S19F	CCL15-CCL14_ENST00000481427.2_Missense_Mutation_p.S19F|CCL14_ENST00000536149.1_5'UTR|RP11-104J23.1_ENST00000590192.1_RNA	NM_032965.4	NP_116741.1	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15	19					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity	p.S19Y(1)		large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGGCCTGGGATCCAAGGAC	0.587000													6	40					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34182085	34182085	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34182085G>A	ENST00000373381.4	-	20	3194	c.3018C>T	c.(3016-3018)ttC>ttT	p.F1006F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	966	CUB 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGAAGGTGTGGAAAGTGAAGA	0.542000													8	17					0	0	1	0	0
RANBP10	57610	broad.mit.edu	37	16	67763633	67763633	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67763633G>A	ENST00000317506.3	-	9	1212	c.1097C>T	c.(1096-1098)cCc>cTc	p.P366L	RANBP10_ENST00000536251.1_Missense_Mutation_p.P137L|RANBP10_ENST00000448631.2_Missense_Mutation_p.P310L|RANBP10_ENST00000411657.2_Missense_Mutation_p.P249L|RANBP10_ENST00000602677.1_Missense_Mutation_p.P366L	NM_020850.1	NP_065901.1	Q6VN20	RBP10_HUMAN	RAN binding protein 10	366	Ser-rich.									endometrium(5)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		ACTGAGGCTGGGGGAGCCAGG	0.607000													22	71					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113173432	113173432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:113173432C>T	ENST00000401783.2	-	37	6895	c.6559G>A	c.(6559-6561)Gaa>Aaa	p.E2187K	SVEP1_ENST00000374469.1_Missense_Mutation_p.E2164K|SVEP1_ENST00000297826.5_Missense_Mutation_p.E113K	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2187	Sushi 13.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CCTGTGGCTTCGCAGGTGCTC	0.507000													20	69					0	0	1	0	0
EML1	2009	broad.mit.edu	37	14	100341315	100341315	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:100341315C>T	ENST00000334192.4	+	4	565	c.431C>T	c.(430-432)tCg>tTg	p.S144L	EML1_ENST00000556758.1_Intron|EML1_ENST00000262233.6_Intron|EML1_ENST00000327921.9_Missense_Mutation_p.S113L	NM_001008707.1	NP_001008707.1	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	127						cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CTGAATAGATCGACACCAAGG	0.378000													25	81					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91726016	91726016	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:91726016C>T	ENST00000359028.2	+	41	9980	c.9755C>T	c.(9754-9756)tCa>tTa	p.S3252L	AKAP9_ENST00000356239.3_Missense_Mutation_p.S3248L|AKAP9_ENST00000358100.2_Missense_Mutation_p.S3198L			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3252					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGAAGTTTTCACTTGAGAGT	0.383000			T	BRAF	papillary thyroid								52	24					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090630	9090630	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9090630G>A	ENST00000397910.4	-	1	1388	c.1185C>T	c.(1183-1185)acC>acT	p.T395T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	395	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGCCACCAAGGGTACCTGGAC	0.512000													10	44					0	0	1	0	0
ITGA1	3672	broad.mit.edu	37	5	52177838	52177838	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:52177838G>A	ENST00000282588.6	+	7	1216	c.758G>A	c.(757-759)gGa>gAa	p.G253E		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	253	VWFA.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				ACAGCTCTTGGAATAGACACA	0.378000													5	27					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157667199	157667199	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:157667199G>A	ENST00000368184.3	-	6	866	c.575C>T	c.(574-576)cCt>cTt	p.P192L	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Missense_Mutation_p.P192L	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	192	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					TCTCAGCACAGGATGTAGAAA	0.527000													11	68					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25311436	25311436	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25311436C>T	ENST00000354189.5	-	4	377	c.342G>A	c.(340-342)gaG>gaA	p.E114E	CASC1_ENST00000557684.1_5'UTR|CASC1_ENST00000545133.1_Intron|CASC1_ENST00000537577.1_Intron|CASC1_ENST00000395987.3_Silent_p.E56E|CASC1_ENST00000395990.2_Silent_p.E10E|CASC1_ENST00000320267.9_Silent_p.E50E	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	50										breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			ATTTTTCTTTCTCAATTCGCT	0.289000													28	34					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48593948	48593948	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48593948G>A	ENST00000323776.5	+	2	385	c.223G>A	c.(223-225)Gga>Aga	p.G75R	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.G38R	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	38					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GCGGGCAAAGGGACCTGAACA	0.388000													7	60					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149502729	149502729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:149502729C>T	ENST00000261799.4	-	15	2528	c.2059G>A	c.(2059-2061)Gga>Aga	p.G687R		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	687	Protein kinase.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	ACCAGGTCTCCGTAGCGGCAG	0.607000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								21	56					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151339220	151339220	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151339220G>A	ENST00000435071.1	-	6	912	c.450C>T	c.(448-450)ttC>ttT	p.F150F	SELENBP1_ENST00000368868.5_Silent_p.F214F|SELENBP1_ENST00000426705.2_Silent_p.F256F|SELENBP1_ENST00000447402.3_Silent_p.F152F			Q13228	SBP1_HUMAN	selenium binding protein 1	214					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCGGGGTTGAAGCCATCTC	0.582000													50	146					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552501	140552501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140552501G>A	ENST00000231137.3	+	1	259	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		29					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCTGGCGCCGAACCGCTTCG	0.517000													25	101					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41957532	41957532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:41957532G>A	ENST00000301831.4	-	8	1202	c.740C>T	c.(739-741)cCt>cTt	p.P247L	ULK4_ENST00000420927.1_Missense_Mutation_p.P247L	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	247	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGAAGCTTTAGGACGAGAAGA	0.274000													29	76					0	0	1	0	0
GOLPH3	64083	broad.mit.edu	37	5	32126481	32126481	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:32126481G>A	ENST00000265070.6	-	4	1049	c.734C>T	c.(733-735)gCc>gTc	p.A245V		NM_022130.3	NP_071413.1	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3 (coat-protein)	245					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	11						GACGTCCGAGGCATGAGCCAG	0.537000													34	70					0	0	1	0	0
STK26	51765	broad.mit.edu	37	X	131206347	131206347	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:131206347C>T	ENST00000394334.2	+	9	1237	c.984C>T	c.(982-984)acC>acT	p.T328T	MST4_ENST00000354719.6_Silent_p.T328T|MST4_ENST00000481105.1_Silent_p.T350T|MST4_ENST00000394335.2_Silent_p.T251T|MST4_ENST00000496850.1_Silent_p.T266T	NM_016542.3	NP_057626.2	Q9P289	MST4_HUMAN		328					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(192;0.000127)					GCTTTACCACCGTACGAAAGA	0.403000													11	24					0	0	1	0	0
ACTR3C	653857	broad.mit.edu	37	7	149983537	149983537	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149983537G>A	ENST00000539352.1	-	5	641	c.390C>T	c.(388-390)atC>atT	p.I130I	ACTR3C_ENST00000252071.4_Silent_p.I130I	NM_001164458.1	NP_001157930.1	Q9C0K3	ARP3C_HUMAN	ARP3 actin-related protein 3 homolog C (yeast)	130					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding										TGATCGCATTGATACCCGTGT	0.413000													15	209					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475124	140475124	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140475124G>A	ENST00000194155.4	+	1	898	c.750G>A	c.(748-750)gaG>gaA	p.E250E		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		250	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTCTATGAGGTGCAGATCC	0.522000													9	63					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11562736	11562736	+	Splice_Site	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:11562736C>G	ENST00000294484.6	+	3	1236	c.1096_splice	c.e3-1	p.G366_splice	PTCHD2_ENST00000389575.3_Splice_Site_p.G366_splice	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	366					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TCCTTGCAGGCTCCCTGGAGC	0.607000													11	17					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60562913	60562913	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:60562913A>T	ENST00000373886.3	+	15	2096	c.2092A>T	c.(2092-2094)Agt>Tgt	p.S698C	BICC1_ENST00000263103.1_Missense_Mutation_p.S324C	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	698					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						GGCTCCAGGGAGTGAGCGCGC	0.532000													11	61					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110855942	110855942	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:110855942C>T	ENST00000375820.4	-	18	1091	c.970G>A	c.(970-972)Gaa>Aaa	p.E324K	COL4A1_ENST00000543140.1_Missense_Mutation_p.E324K	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	324	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGACCTGCTTCACCCTTTTCT	0.458000													35	125					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56663166	56663166	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56663166G>A	ENST00000389934.3	-	18	3183	c.3066C>T	c.(3064-3066)ttC>ttT	p.F1022F	TEX14_ENST00000240361.8_Silent_p.F1028F|TEX14_ENST00000349033.5_Silent_p.F1022F	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	1028						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACTTACTGGTGAAGCTTCCAA	0.517000													36	66					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155498001	155498001	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:155498001G>A	ENST00000461783.3	+	12	3686	c.2413G>A	c.(2413-2415)Gac>Aac	p.D805N	TIAM2_ENST00000456144.1_Missense_Mutation_p.D805N|TIAM2_ENST00000456877.2_Missense_Mutation_p.D117N|TIAM2_ENST00000318981.5_Missense_Mutation_p.D805N|TIAM2_ENST00000360366.4_Missense_Mutation_p.D829N|TIAM2_ENST00000529824.2_Missense_Mutation_p.D805N|TIAM2_ENST00000528391.2_Missense_Mutation_p.D141N|TIAM2_ENST00000367174.2_Missense_Mutation_p.D181N			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	805					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGTTCCCCGAGACAATGCATG	0.403000													57	71					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19191795	19191795	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:19191795C>T	ENST00000562034.1	+	2	3880	c.82C>T	c.(82-84)Ccg>Tcg	p.P28S	SYT17_ENST00000355377.2_Missense_Mutation_p.P89S|SYT17_ENST00000568115.1_Missense_Mutation_p.P28S|SYT17_ENST00000562711.2_Missense_Mutation_p.P85S			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	89	Cys-rich.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						GACCAATTCCCCGGATGGAAG	0.572000											OREG0023658	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	58					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50684558	50684558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50684558C>T	ENST00000446044.1	+	12	1516	c.920C>T	c.(919-921)tCg>tTg	p.S307L	MAPKAPK3_ENST00000357955.2_Missense_Mutation_p.S307L	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	307					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		TTCCAGCAATCGATGGTAGTG	0.602000													7	9					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7563999	7563999	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7563999G>A	ENST00000379802.3	+	6	1098	c.757G>A	c.(757-759)Gag>Aag	p.E253K	DSP_ENST00000418664.2_Missense_Mutation_p.E253K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	253	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCAGTTGGAGGAGGAGTATGA	0.398000													25	73					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497271	141497271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141497271C>T	ENST00000264952.2	+	1	282	c.145C>T	c.(145-147)Cgc>Tgc	p.R49C		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	49					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						CGCGGAGCTCCGCCAGAAGCT	0.682000													5	33					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121447	50121447	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50121447C>T	ENST00000374160.3	-	1	830	c.754G>A	c.(754-756)Gaa>Aaa	p.E252K	RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Missense_Mutation_p.E252K|WDFY4_ENST00000413659.2_Intron|WDFY4_ENST00000325239.5_Intron	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	252						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CTCCAGTCTTCCCAGGAGTCC	0.547000													72	145					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15637062	15637062	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:15637062C>T	ENST00000281171.4	+	2	560	c.230C>T	c.(229-231)aCt>aTt	p.T77I	PTPRO_ENST00000543886.1_Missense_Mutation_p.T77I|PTPRO_ENST00000348962.2_Missense_Mutation_p.T77I	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	77	Fibronectin type-III 1.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TTCAACAGCACTTTGCCTCCT	0.393000													21	54					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196852768	196852768	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:196852768G>A	ENST00000312428.6	-	13	1639	c.1539C>T	c.(1537-1539)ctC>ctT	p.L513L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	513	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GATTTTCTGCGAGGAAGTTAT	0.348000													25	41					0	0	1	0	0
SMAD7	4092	broad.mit.edu	37	18	46447850	46447850	+	Silent	SNP	C	C	T	rs34151545	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:46447850C>T	ENST00000262158.2	-	4	1459	c.1173G>A	c.(1171-1173)acG>acA	p.T391T	SMAD7_ENST00000589634.1_Silent_p.T390T|SMAD7_ENST00000591805.1_Silent_p.T176T	NM_001190821.1|NM_005904.3	NP_001177750.1|NP_005895.1	O15105	SMAD7_HUMAN	SMAD family member 7	391	MH2.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	10	Colorectal(1;0.0518)					CGGTAAAGCCCGTCCACGGCT	0.577000													13	30					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52514365	52514365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52514365C>T	ENST00000488380.1	+	13	1607	c.1582C>T	c.(1582-1584)Ccc>Tcc	p.P528S	NISCH_ENST00000345716.4_Intron|NISCH_ENST00000479054.1_Intron|NISCH_ENST00000420808.2_Intron	NM_001276293.1	NP_001263222.1	Q9Y2I1	NISCH_HUMAN	nischarin	0	Interaction with PAK1 (By similarity).|Necessary for homooligomerization and targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TGCCTGGGCCCCCTGGCTGGG	0.647000													11	7					0	0	1	0	0
KANK3	256949	broad.mit.edu	37	19	8397899	8397899	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8397899C>T	ENST00000330915.3	-	7	2000	c.1936_splice	c.e7+1	p.T645_splice	KANK3_ENST00000593649.1_Splice_Site_p.T645_splice	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	645										breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GGCTCTGACCCGTATCCAGGA	0.632000													4	14					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35800925	35800925	+	Silent	SNP	C	C	T	rs148978165		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:35800925C>T	ENST00000361922.4	+	8	1530	c.1380C>T	c.(1378-1380)ttC>ttT	p.F460F	MAG_ENST00000392213.3_Silent_p.F460F|MAG_ENST00000593348.1_3'UTR|MAG_ENST00000537831.2_Silent_p.F435F	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	460	Ig-like C2-type 4.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			AGCGGGAGTTCGTGTACTCGG	0.682000													23	103					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974663	29974663	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29974663G>A	ENST00000376797.3	-	0	1346				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA																							CTACGTGGACGACACGCAGTT	0.667000													8	6					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134179608	134179608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:134179608G>A	ENST00000431683.2	+	11	1050	c.1050G>A	c.(1048-1050)atG>atA	p.M350I		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	350					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TTGGTTTCATGAACGGGGCCA	0.493000													4	20					0	0	1	0	0
FGFBP1	9982	broad.mit.edu	37	4	15938219	15938219	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:15938219G>A	ENST00000382333.1	-	3	331	c.37C>T	c.(37-39)Cta>Tta	p.L13L	FGFBP1_ENST00000259988.2_Silent_p.L13L	NM_005130.4	NP_005121.1	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	13					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|prostate(2)|skin(1)	10						GCAGCCAGTAGGAGGAAGGAG	0.522000													16	90					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48346900	48346900	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48346900G>A	ENST00000319856.4	+	1	429	c.408G>A	c.(406-408)gaG>gaA	p.E136E		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						GAGGTGTTGAGATCATTCTGC	0.483000													22	204					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79433634	79433634	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:79433634G>A	ENST00000554719.1	+	10	2233	c.1742G>A	c.(1741-1743)tGg>tAg	p.W581*	NRXN3_ENST00000335750.5_Nonsense_Mutation_p.W581*	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	173					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GACAACCAGTGGCACAATGTC	0.448000													7	88					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164272255	164272255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164272255G>A	ENST00000515560.1	+	4	2352	c.830G>A	c.(829-831)tGg>tAg	p.W277*	NPY5R_ENST00000506953.1_Nonsense_Mutation_p.W277*|NPY5R_ENST00000338566.3_Nonsense_Mutation_p.W277*			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	277					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				AGCCATAAATGGAGTTATTCA	0.398000													28	79					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26572089	26572089	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:26572089G>A	ENST00000381340.3	-	50	7419	c.7003C>T	c.(7003-7005)Cgt>Tgt	p.R2335C	RP11-513G19.1_ENST00000535324.1_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2335					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					CGGTACCCACGGGTGAACGTG	0.433000													33	56					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96706525	96706525	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:96706525C>T	ENST00000389672.5	+	3	840	c.802C>T	c.(802-804)Cgt>Tgt	p.R268C	EPHA6_ENST00000470610.2_Missense_Mutation_p.R268C|EPHA6_ENST00000542517.1_Missense_Mutation_p.R174C	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	173						integral to plasma membrane	ATP binding|ephrin receptor activity	p.R174C(3)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CACTGAAATTCGTGAGGTGGG	0.443000													89	238					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9998483	9998483	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:9998483G>A	ENST00000506583.1	-	5	462	c.245C>T	c.(244-246)tCt>tTt	p.S82F	SLC2A9_ENST00000264784.3_Missense_Mutation_p.S111F|SLC2A9_ENST00000309065.3_Missense_Mutation_p.S82F			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	111					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						CACAGTCACAGACCAGAGCAA	0.453000													35	56					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51201152	51201152	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51201152G>A	ENST00000293441.1	-	12	1827	c.1809C>T	c.(1807-1809)ttC>ttT	p.F603F	SHANK1_ENST00000359082.3_Silent_p.F603F|SHANK1_ENST00000391814.1_Silent_p.F603F	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	603	SH3.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AGTCAGAGGGGAACCAGCCAA	0.552000													20	32					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15806999	15806999	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15806999G>A	ENST00000550308.1	+	11	1658	c.1278G>A	c.(1276-1278)ggG>ggA	p.G426G	CYP4F12_ENST00000324632.9_Silent_p.G426G	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					ATATTATAGGGGTCCATCACA	0.552000													40	106					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104499567	104499567	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104499567C>T	ENST00000361820.3	-	1	1295	c.695G>A	c.(694-696)aGt>aAt	p.S232N		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	232					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TCTCACCTGACTCTCCCGTGG	0.602000													13	34					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112021399	112021399	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:112021399G>A	ENST00000354650.3	-	9	1376	c.770C>T	c.(769-771)tCt>tTt	p.S257F	FYN_ENST00000368667.2_Missense_Mutation_p.S257F|FYN_ENST00000538466.1_Intron|FYN_ENST00000368678.4_Intron|FYN_ENST00000229471.4_Intron|FYN_ENST00000229470.5_Intron|FYN_ENST00000356013.2_Intron|FYN_ENST00000476769.2_5'UTR|FYN_ENST00000368682.3_Intron	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	257					axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	GGTTTTGACAGACAGATCGGT	0.537000													30	74					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377319	55377319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55377319C>T	ENST00000326321.3	+	7	1093	c.1060C>T	c.(1060-1062)Ctc>Ttc	p.L354F	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.L354F|KIR3DL2_ENST00000270442.5_Missense_Mutation_p.L337F	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	354					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		cctcttcatcctcctcctctt	0.493000													24	58					0	0	1	0	0
PDGFB	5155	broad.mit.edu	37	22	39629528	39629528	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:39629528C>T	ENST00000331163.6	-	3	949	c.160_splice	c.e3-1	p.E54_splice	PDGFB_ENST00000381551.4_Splice_Site_p.E39_splice	NM_002608.2	NP_002599.1	P01127	PDGFB_HUMAN	platelet-derived growth factor beta polypeptide	54					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(429)	central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Melanoma(58;0.04)				Becaplermin(DB00102)	CCCCATCTTCCTCTGCAGGAG	0.652000			T	COL1A1	DFSP								23	62					0	0	1	0	0
IGFBP4	3487	broad.mit.edu	37	17	38609376	38609376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38609376G>A	ENST00000269593.4	+	2	764	c.489G>A	c.(487-489)cgG>cgA	p.R163R	IGFBP4_ENST00000542955.1_Silent_p.R63R	NM_001552.2	NP_001543.2	P22692	IBP4_HUMAN	insulin-like growth factor binding protein 4	163					DNA metabolic process|signal transduction|skeletal system development					NS(1)|endometrium(1)|kidney(1)|large_intestine(2)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GGGCGCCCCGGGAGGATGCCC	0.617000													16	16					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66937441	66937441	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:66937441C>T	ENST00000374690.3	+	5	2819	c.2295C>T	c.(2293-2295)ttC>ttT	p.F765F	AR_ENST00000396043.2_Silent_p.F233F|AR_ENST00000396044.3_Intron	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	764	Interaction with MYST2.|Ligand-binding.		A -> T (in AIS; loss of androgen binding).|A -> V (in AIS).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TGCTCTACTTCGCCCCTGATC	0.542000									Androgen Insensitivity Syndrome				24	19					0	0	1	0	0
INHBA	3624	broad.mit.edu	37	7	41729268	41729268	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:41729268C>T	ENST00000242208.4	-	3	1507	c.1261G>A	c.(1261-1263)Gag>Aag	p.E421K	INHBA_ENST00000464515.1_5'UTR|AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000442711.1_Missense_Mutation_p.E421K	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	421					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						CCACACTCCTCCACGATCATG	0.463000										TSP Lung(11;0.080)			39	83					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22311705	22311705	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:22311705G>A	ENST00000398793.2	-	18	2804	c.2370C>T	c.(2368-2370)ctC>ctT	p.L790L	TOP3B_ENST00000357179.5_Silent_p.L790L	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	790					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		CATCGCCCGGGAGTGGGGACT	0.642000													4	21					0	0	1	0	0
ALDOB	229	broad.mit.edu	37	9	104192174	104192174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:104192174G>A	ENST00000374855.4	-	3	311	c.187C>T	c.(187-189)Ctc>Ttc	p.L63F	ALDOB_ENST00000468981.2_Intron	NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	63					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				ACAGAGAAGAGGATTTCTCGG	0.552000													54	103					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38941514	38941514	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38941514G>A	ENST00000302328.3	-	13	2091	c.1893C>T	c.(1891-1893)ctC>ctT	p.L631L	SCN11A_ENST00000456224.3_Silent_p.L631L|SCN11A_ENST00000444237.2_Silent_p.L631L|SCN11A_ENST00000450244.1_Silent_p.L631L	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	631					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGTAGGGATCGAGCGCAATGA	0.413000													16	37					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142458111	142458111	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:142458111G>A	ENST00000430863.1	-	0	2795					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GGAGGGCCAGGAAGAGCTTGG	0.667000													7	8					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74640336	74640336	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74640336G>A	ENST00000268053.6	-	2	484	c.330C>T	c.(328-330)ctC>ctT	p.L110L	CYP11A1_ENST00000541301.1_Silent_p.L110L|CYP11A1_ENST00000358632.4_5'UTR|CYP11A1_ENST00000419019.2_Intron	NM_000781.2	NP_000772.2	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1	110					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CGGACTTAAAGAGAAGGGCCA	0.577000													14	66					0	0	1	0	0
ACTG1P17	283693	broad.mit.edu	37	15	83395970	83395970	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83395970C>T	ENST00000560958.1	-	0	316					NR_036446.1																						GAGGCCTGCTCCATGGGGTGC	0.612000													5	20					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3228099	3228099	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3228099C>T	ENST00000217939.6	-	7	8299	c.8145G>A	c.(8143-8145)acG>acA	p.T2715T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2715	Ig-like C2-type 11.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGCCGTACTCCGTCTCCATCC	0.617000													28	22					0	0	1	0	0
GNG4	2786	broad.mit.edu	37	1	235715446	235715446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:235715446G>A	ENST00000391854.2	-	4	644	c.191C>T	c.(190-192)cCc>cTc	p.P64L	GNG4_ENST00000366598.4_Missense_Mutation_p.P64L|GNG4_ENST00000366597.1_Missense_Mutation_p.P64L|GNG4_ENST00000450593.1_Missense_Mutation_p.P64L|GNG4_ENST00000484517.1_5'UTR	NM_001098722.1|NM_004485.3	NP_001092192.1|NP_004476.1	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein), gamma 4	64					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity			NS(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			CTCGCGAAAGGGGTTTTCTGA	0.522000													57	147					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61226934	61226934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:61226934G>A	ENST00000382768.1	+	3	427	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	SERPINB12_ENST00000269491.1_Missense_Mutation_p.E123K			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	123					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TGGAGAGCAGGAATTCCCAAT	0.463000													11	123					0	0	1	0	0
IPPK	64768	broad.mit.edu	37	9	95410411	95410411	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:95410411G>A	ENST00000287996.3	-	6	710	c.434C>T	c.(433-435)cCt>cTt	p.P145L		NM_022755.5	NP_073592.1	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	145					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(2)|urinary_tract(1)	15						ACTCGAGAAAGGAATAAACCC	0.413000													4	31					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92251698	92251698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92251698G>A	ENST00000435962.2	-	11	1493	c.1170C>T	c.(1168-1170)ttC>ttT	p.F390F	TC2N_ENST00000360594.5_Silent_p.F390F|TC2N_ENST00000340892.5_Silent_p.F390F|TC2N_ENST00000556018.1_Silent_p.F326F	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	390	C2.					nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		CCACCTTCACGAAAAAACCTA	0.323000													82	215					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36227703	36227703	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36227703C>T	ENST00000222270.7	+	31	7272	c.7272C>T	c.(7270-7272)ttC>ttT	p.F2424F	WBP7_ENST00000420124.1_Silent_p.F2424F|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					AGGATGGGTTCAGCGTTGAGG	0.577000													27	67					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156378712	156378712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156378712G>A	ENST00000274532.2	-	3	546	c.490C>T	c.(490-492)Cca>Tca	p.P164S	TIMD4_ENST00000407087.3_Missense_Mutation_p.P164S	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	164	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTGCAGCTGGGGTTGTTGTC	0.532000													83	184					0	0	1	0	0
CABYR	26256	broad.mit.edu	37	18	21739520	21739520	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21739520G>A	ENST00000399496.3	+	5	791	c.626G>A	c.(625-627)gGt>gAt	p.G209D	RP11-799B12.4_ENST00000583267.1_lincRNA|CABYR_ENST00000415309.2_Intron|CABYR_ENST00000399481.2_3'UTR|CABYR_ENST00000399499.1_Missense_Mutation_p.G209D|CABYR_ENST00000327201.6_Missense_Mutation_p.G111D|CABYR_ENST00000581397.1_Missense_Mutation_p.G209D	NM_012189.2|NM_153769.1	NP_036321.2|NP_722453.1	O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	394					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					AATCAACAAGGTCACCCATCA	0.443000													33	84					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60549102	60549102	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:60549102T>C	ENST00000373886.3	+	7	685	c.681T>C	c.(679-681)tcT>tcC	p.S227S		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	227					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						ATTCCCCCTCTATTCAGCATA	0.403000													44	98					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81212437	81212437	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81212437C>T	ENST00000394685.3	+	15	2219	c.1800C>T	c.(1798-1800)atC>atT	p.I600I	RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000356249.5_Silent_p.I600I|KIAA1199_ENST00000220244.3_Silent_p.I600I			Q8WUJ3	K1199_HUMAN	KIAA1199	600										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CCCTGCAGATCAAGGACGTTG	0.488000													63	64					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158323823	158323823	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158323823G>A	ENST00000444681.2	+	1	338	c.45G>A	c.(43-45)ggG>ggA	p.G15G	CD1E_ENST00000368161.3_Silent_p.G15G|CD1E_ENST00000368166.3_Silent_p.G15G|CD1E_ENST00000452291.2_Silent_p.G15G|CD1E_ENST00000368167.3_Silent_p.G15G|CD1E_ENST00000368163.3_Silent_p.G15G|CD1E_ENST00000368155.3_Silent_p.G15G|CD1E_ENST00000368160.3_Silent_p.G15G|CD1E_ENST00000368156.1_Silent_p.G15G|CD1E_ENST00000434258.1_Intron|CD1E_ENST00000368157.1_Silent_p.G15G|CD1E_ENST00000368154.1_Silent_p.G15G|CD1E_ENST00000368164.3_Silent_p.G15G|CD1E_ENST00000368165.3_Silent_p.G15G	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	15			G -> E (in dbSNP:rs3180089).		antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GCTGTCCTGGGGAAAATACAG	0.542000													6	59					0	0	1	0	0
GPN3	51184	broad.mit.edu	37	12	110895368	110895368	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:110895368G>A	ENST00000543199.1	-	4	598	c.514C>T	c.(514-516)Cga>Tga	p.R172*	GPN3_ENST00000228827.3_Nonsense_Mutation_p.R133*|GPN3_ENST00000537466.2_Nonsense_Mutation_p.R143*	NM_001164372.1	NP_001157844.1	Q9UHW5	GPN3_HUMAN	GPN-loop GTPase 3	133						protein complex	GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|urinary_tract(1)	8						CCACAGACTCGGAACTCCCAC	0.393000													19	43					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96135801	96135801	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96135801C>T	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		ctcctgacctcgtgatccgcc	0.483000			T	TRA@	T-ALL								5	21					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176696688	176696688	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176696688C>T	ENST00000439151.2	+	16	5434	c.5389C>T	c.(5389-5391)Ctc>Ttc	p.L1797F	NSD1_ENST00000361032.4_Missense_Mutation_p.L1694F|NSD1_ENST00000354179.4_Missense_Mutation_p.L1528F|NSD1_ENST00000347982.4_Missense_Mutation_p.L1528F	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1797	PWWP 2.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GTTCCCAGTCCTCTTTTTTGG	0.498000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			28	78					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23379202	23379202	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23379202C>T	ENST00000343070.2	+	5	978	c.802C>T	c.(802-804)Cac>Tac	p.H268Y	SCNN1B_ENST00000568923.1_Missense_Mutation_p.H241Y|SCNN1B_ENST00000568085.1_Missense_Mutation_p.H268Y|SCNN1B_ENST00000307331.5_Missense_Mutation_p.H313Y	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	268					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CTTCTACCCTCACTATGGCAA	0.527000													35	132					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782829	54782829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54782829G>A	ENST00000391748.1	-	6	920	c.793C>T	c.(793-795)Cgc>Tgc	p.R265C	LILRB2_ENST00000434421.1_Missense_Mutation_p.R149C|LILRB2_ENST00000391746.1_Missense_Mutation_p.R265C|LILRB2_ENST00000314446.5_Missense_Mutation_p.R265C|LILRB2_ENST00000391749.4_Missense_Mutation_p.R265C	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	265	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGAGCTGGCGAAGGTCACGT	0.642000													16	85					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110489536	110489536	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110489536C>T	ENST00000378402.5	+	53	9104	c.9000C>T	c.(8998-9000)ttC>ttT	p.F3000F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3000					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTATTAATTTCCAAGCTTACT	0.423000										HNSCC(38;0.096)			16	55					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113303820	113303820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113303820G>A	ENST00000297405.5	-	56	9137	c.8893C>T	c.(8893-8895)Cct>Tct	p.P2965S	CSMD3_ENST00000352409.3_Missense_Mutation_p.P2895S|CSMD3_ENST00000343508.3_Missense_Mutation_p.P2925S|CSMD3_ENST00000455883.2_Missense_Mutation_p.P2796S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2965	Sushi 20.					integral to membrane|plasma membrane		p.P2965S(1)|p.P2925S(1)|p.P2965T(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAATATCCAGGATTGCAGTCA	0.343000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	91					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38639232	38639232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38639232C>T	ENST00000413689.1	-	14	2443	c.2250G>A	c.(2248-2250)caG>caA	p.Q750Q	SCN5A_ENST00000423572.2_Silent_p.Q750Q|SCN5A_ENST00000425664.1_Silent_p.Q750Q|SCN5A_ENST00000455624.2_Silent_p.Q750Q|SCN5A_ENST00000450102.2_Silent_p.Q750Q|SCN5A_ENST00000449557.2_Silent_p.Q750Q|SCN5A_ENST00000414099.2_Silent_p.Q750Q|SCN5A_ENST00000451551.2_Silent_p.Q750Q|SCN5A_ENST00000333535.4_Silent_p.Q750Q|SCN5A_ENST00000443581.1_Silent_p.Q750Q	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	750					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGTTTCCGACCTGCAGCATCT	0.552000													13	46					0	0	1	0	0
CCDC134	79879	broad.mit.edu	37	22	42209433	42209433	+	Missense_Mutation	SNP	C	C	T	rs148694139		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:42209433C>T	ENST00000255784.5	+	5	580	c.476C>T	c.(475-477)tCg>tTg	p.S159L	CCDC134_ENST00000402061.3_Intron	NM_024821.2	NP_079097.1	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134	159						extracellular region				large_intestine(1)|lung(2)|ovary(2)|skin(1)	6						GGGCCCCACTCGCCCATCCTC	0.587000													18	43					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3686422	3686422	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:3686422C>T	ENST00000344754.4	-	3	674	c.675G>A	c.(673-675)agG>agA	p.R225R	SIGLEC1_ENST00000202578.4_Silent_p.R225R	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	225	Ig-like C2-type 1.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CGCTCTGAGCCCTGTGATTGG	0.627000													29	72					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56085986	56085986	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56085986C>T	ENST00000312711.1	+	1	204	c.204C>T	c.(202-204)ttC>ttT	p.F68F		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					ATCTGGCTTTCATGGATCTTG	0.383000													64	164					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144857686	144857686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:144857686G>A	ENST00000369359.4	-	42	6814	c.6776C>T	c.(6775-6777)tCc>tTc	p.S2259F	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S2123F|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S2123F|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S2017F|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S2208F			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2123					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAGAGCTGGGGAATTCATACC	0.522000			T	PDGFRB	MPD								46	199					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138293	126138293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:126138293G>A	ENST00000299308.3	+	9	2282	c.2274G>A	c.(2272-2274)ttG>ttA	p.L758L	TMEM132B_ENST00000535886.1_Silent_p.L270L	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	758						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAGGGCCTTTGATTAAGTTAG	0.438000													18	118					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125396438	125396438	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:125396438G>A	ENST00000536769.1	-	1	3456	c.1880C>T	c.(1879-1881)cCc>cTc	p.P627L	UBC_ENST00000538617.1_Missense_Mutation_p.P247L|UBC_ENST00000546120.1_Missense_Mutation_p.P551L|UBC_ENST00000339647.5_Missense_Mutation_p.P627L			P0CG48	UBC_HUMAN	ubiquitin C	627	Ubiquitin-like 9.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGTGTCACTGGGCTCCACCTC	0.527000													63	167					0	0	1	0	0
CHST10	9486	broad.mit.edu	37	2	101012051	101012051	+	Silent	SNP	G	G	A	rs138672369		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:101012051G>A	ENST00000264249.3	-	6	838	c.453C>T	c.(451-453)atC>atT	p.I151I	CHST10_ENST00000409701.1_Silent_p.I151I|CHST10_ENST00000542617.1_Silent_p.I199I	NM_004854.4	NP_004845.1	O43529	CHSTA_HUMAN	carbohydrate sulfotransferase 10	151					carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)	16						CGTTTTCGGGGATCTCCTCAA	0.522000													28	77					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25243010	25243010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:25243010C>T	ENST00000354454.3	+	13	1314	c.485C>T	c.(484-486)tCt>tTt	p.S162F	LRMP_ENST00000547044.1_Missense_Mutation_p.S162F|LRMP_ENST00000548766.1_Missense_Mutation_p.S162F	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	218					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					CTCAGATTATCTTTGGGATTT	0.393000													47	114					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32868615	32868615	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32868615C>T	ENST00000380250.3	+	60	9187	c.8691C>T	c.(8689-8691)acC>acT	p.T2897T	FRY_ENST00000380217.1_Silent_p.T79T|FRY_ENST00000542859.1_Silent_p.T267T	NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2897					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCGAGCCCACCTTCACGTCCA	0.557000													24	74					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109683539	109683539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109683539C>T	ENST00000338432.7	+	38	5406	c.5287C>T	c.(5287-5289)Cct>Tct	p.P1763S	ACACB_ENST00000377848.3_Missense_Mutation_p.P1763S|ACACB_ENST00000543201.1_Missense_Mutation_p.P429S|ACACB_ENST00000377854.5_Missense_Mutation_p.P1693S			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1763					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GAACCGACTTCCTGGTGGAAA	0.507000													24	67					0	0	1	0	0
TNFSF8	944	broad.mit.edu	37	9	117666496	117666496	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117666496G>A	ENST00000223795.2	-	4	533	c.420C>T	c.(418-420)ttC>ttT	p.F140F	TNFSF8_ENST00000474301.1_Intron	NM_001244.3	NP_001235.1	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily, member 8	140					cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(3)|urinary_tract(1)	12						GGCAAATGATGAAGTACAAAC	0.413000													66	101					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94899510	94899510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:94899510G>A	ENST00000357742.4	+	8	1150	c.1150G>A	c.(1150-1152)Gat>Aat	p.D384N	MCTP2_ENST00000543482.1_Missense_Mutation_p.D384N|MCTP2_ENST00000451018.3_Missense_Mutation_p.D384N|MCTP2_ENST00000331706.4_5'UTR|MCTP2_ENST00000557742.1_5'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	384	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAAACTGGGAGATCAGAGGTA	0.333000													57	66					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114296106	114296106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114296106G>A	ENST00000309235.5	+	4	747	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	ZNF483_ENST00000358151.4_Missense_Mutation_p.E197K|ZNF483_ENST00000355824.3_Missense_Mutation_p.E197K	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	197	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GCTATATAAGGAAGTGCTACT	0.398000													55	77					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10031943	10031943	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10031943C>T	ENST00000396573.2	-	4	1189	c.880G>A	c.(880-882)Gac>Aac	p.D294N	GRIN2A_ENST00000404927.2_Missense_Mutation_p.D294N|GRIN2A_ENST00000562109.1_Missense_Mutation_p.D294N|GRIN2A_ENST00000330684.3_Missense_Mutation_p.D294N|GRIN2A_ENST00000396575.2_Missense_Mutation_p.D294N|GRIN2A_ENST00000535259.1_Missense_Mutation_p.D137N	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	294					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCAATGCCGTCCCTCACTCTC	0.572000													16	38					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41400142	41400142	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:41400142C>T	ENST00000373198.3	-	5	852	c.617G>A	c.(616-618)gGg>gAg	p.G206E	PTPRT_ENST00000373193.3_Missense_Mutation_p.G206E|PTPRT_ENST00000373184.1_Missense_Mutation_p.G206E|PTPRT_ENST00000373201.1_Missense_Mutation_p.G206E|PTPRT_ENST00000373190.1_Missense_Mutation_p.G206E|PTPRT_ENST00000373187.1_Missense_Mutation_p.G206E|PTPRT_ENST00000356100.2_Missense_Mutation_p.G206E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	206	Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCATTCTGCCCCACATTCAC	0.493000													56	164					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100010	110100010	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110100010C>T	ENST00000518632.1	+	2	620	c.269C>T	c.(268-270)tCc>tTc	p.S90F	TRHR_ENST00000311762.2_Missense_Mutation_p.S90F			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	90						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			ATCTACGGTTCCTGGGTCTAT	0.498000													20	101					0	0	1	0	0
REN	5972	broad.mit.edu	37	1	204129793	204129793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204129793G>A	ENST00000367195.2	-	4	430	c.387C>T	c.(385-387)ctC>ctT	p.L129L	REN_ENST00000272190.8_Silent_p.L129L			P00797	RENI_HUMAN	renin	129					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AAGCATCGAAGAGCTTGTGAT	0.552000													31	93					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47514289	47514289	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47514289G>A	ENST00000371901.3	+	10	1510	c.1260G>A	c.(1258-1260)tgG>tgA	p.W420*	CYP4X1_ENST00000538609.1_Nonsense_Mutation_p.W419*	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	420						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						CTGCTGTCTGGAAAAACCCAA	0.418000													63	171					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6184597	6184597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6184597C>T	ENST00000261405.5	-	7	1032	c.778G>A	c.(778-780)Ggg>Agg	p.G260R		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	260					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CACTCCAGCCCCCCAGCACAC	0.642000													8	52					0	0	1	0	0
OIT3	170392	broad.mit.edu	37	10	74673193	74673193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:74673193C>T	ENST00000334011.5	+	6	1136	c.918C>T	c.(916-918)ctC>ctT	p.L306L		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	306	ZP.					nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					TCAACATCCTCTTCTCTCTCA	0.552000													35	71					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105415701	105415701	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105415701C>T	ENST00000333244.5	-	7	6206	c.6087G>A	c.(6085-6087)ggG>ggA	p.G2029G	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2029						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCTTCAGGTCCCCCTGCATGG	0.662000													86	88					0	0	1	0	0
NDUFB4	4710	broad.mit.edu	37	3	120319969	120319969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:120319969C>T	ENST00000485064.1	+	2	224	c.192C>T	c.(190-192)gcC>gcT	p.A64A	NDUFB4_ENST00000184266.2_Silent_p.A64A|NDUFB4_ENST00000492739.1_Intron	NM_001168331.1	NP_001161803.1	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa	64					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|large_intestine(1)|lung(3)	5				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	AAAATCCTGCCTTGCTTCGTT	0.393000													44	141					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22059407	22059407	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22059407C>T	ENST00000306385.5	+	16	2869	c.2199C>T	c.(2197-2199)ttC>ttT	p.F733F	BMP1_ENST00000354870.5_3'UTR	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	733	EGF-like 2; calcium-binding (Potential).				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GCAGTGGCTTCGTCCTCCATG	0.602000													4	23					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540532	94540532	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94540532C>T	ENST00000289495.5	+	1	1323	c.1107C>T	c.(1105-1107)ttC>ttT	p.F369F	PPP1R9A_ENST00000340694.4_Silent_p.F369F|PPP1R9A_ENST00000424654.1_Silent_p.F369F|PPP1R9A_ENST00000456331.2_Silent_p.F369F|PPP1R9A_ENST00000433881.1_Silent_p.F369F|PPP1R9A_ENST00000433360.1_Silent_p.F369F	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	369						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GTGGTGATTTCACCTCTCCTG	0.433000										HNSCC(28;0.073)			32	56					0	0	1	0	0
ZBTB21	49854	broad.mit.edu	37	21	43411770	43411770	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43411770G>A	ENST00000310826.5	-	3	2618	c.2435C>T	c.(2434-2436)cCc>cTc	p.P812L	ZBTB21_ENST00000465968.1_5'UTR|ZBTB21_ENST00000398511.3_Missense_Mutation_p.P812L|ZBTB21_ENST00000398505.3_Missense_Mutation_p.P611L|ZBTB21_ENST00000398499.1_Missense_Mutation_p.P812L	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21																		GTCCAAAACGGGCAAAGAAAA	0.502000													42	93					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169433294	169433294	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169433294C>T	ENST00000261509.6	+	2	850	c.639C>T	c.(637-639)gcC>gcT	p.A213A	PALLD_ENST00000333488.4_Silent_p.A90A|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Silent_p.A213A	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	213					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		AGCCGTCAGCCCTGCTGAGTG	0.552000									Pancreatic Cancer, Familial Clustering of				16	107					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107732807	107732807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107732807C>T	ENST00000388781.3	-	13	1608	c.1525G>A	c.(1525-1527)Gat>Aat	p.D509N	LAMB4_ENST00000205386.4_Missense_Mutation_p.D509N|LAMB4_ENST00000414450.2_Missense_Mutation_p.D509N|LAMB4_ENST00000388780.3_Missense_Mutation_p.D509N	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	509	Laminin EGF-like 5; truncated.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CCTCCAATATCACAGTCACAG	0.383000													24	58					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18753417	18753417	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18753417G>A	ENST00000380548.4	+	16	2467	c.2128G>A	c.(2128-2130)Gag>Aag	p.E710K		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	710	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCTGGCTGATGAGCTGTGTCG	0.567000													8	13					0	0	1	0	0
TBATA	219793	broad.mit.edu	37	10	72538330	72538330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:72538330C>T	ENST00000299290.1	-	6	879	c.490G>A	c.(490-492)Gaa>Aaa	p.E164K	TBATA_ENST00000545575.1_Missense_Mutation_p.E153K|TBATA_ENST00000456372.2_Missense_Mutation_p.E164K	NM_152710.2	NP_689923.2			thymus, brain and testes associated																		TTCTTCAGTTCATCCTCCTTG	0.557000													71	160					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219883777	219883777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:219883777C>T	ENST00000341552.5	-	21	3681	c.3598G>A	c.(3598-3600)Gac>Aac	p.D1200N	CCDC108_ENST00000441968.1_Missense_Mutation_p.D1200N|CCDC108_ENST00000453220.1_Missense_Mutation_p.D1200N	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1200						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCATACCAGTCCAGGGACACC	0.602000													15	188					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158283902	158283902	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:158283902C>T	ENST00000264192.3	-	6	628	c.507G>A	c.(505-507)ctG>ctA	p.L169L	CYTIP_ENST00000540637.1_Silent_p.L63L	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	169	Interaction with CYTH1.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						CCGTTCTTTTCAGAATCATTG	0.348000													11	25					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16528293	16528293	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:16528293G>A	ENST00000270747.3	-	14	2266	c.2130C>T	c.(2128-2130)gtC>gtT	p.V710V	ARHGEF19_ENST00000478117.1_5'UTR|ARHGEF19_ENST00000421561.1_Intron	NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	710					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CCTCACTGATGACCTCCTTGT	0.592000													7	29					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47538583	47538583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:47538583G>A	ENST00000300527.4	+	13	1276	c.1172G>A	c.(1171-1173)gGa>gAa	p.G391E	COL6A2_ENST00000397763.1_Missense_Mutation_p.G391E|COL6A2_ENST00000409416.1_Missense_Mutation_p.G391E|COL6A2_ENST00000310645.5_Missense_Mutation_p.G391E|COL6A2_ENST00000357838.4_Missense_Mutation_p.G391E	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	391	Triple-helical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GGGGCCAAGGGAAGCAAGGTG	0.642000													6	14					0	0	1	0	0
FGF18	8817	broad.mit.edu	37	5	170883572	170883572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:170883572C>T	ENST00000274625.5	+	5	931	c.387C>T	c.(385-387)ttC>ttT	p.F129F		NM_003862.2	NP_003853.1	O76093	FGF18_HUMAN	fibroblast growth factor 18	129					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	9	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGTGTGTGTTCATCGAGAAGG	0.567000													32	81					0	0	1	0	0
SLC9A8	23315	broad.mit.edu	37	20	48472032	48472032	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:48472032C>T	ENST00000417961.1	+	8	885	c.675C>T	c.(673-675)ttC>ttT	p.F225F	SLC9A8_ENST00000541138.1_5'UTR|SLC9A8_ENST00000539601.1_5'UTR|SLC9A8_ENST00000361573.2_Silent_p.F209F	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	209						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TTGCCATTTTCAATGCACTTC	0.478000													42	101					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36271691	36271691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36271691C>T	ENST00000007510.4	+	10	946	c.802C>T	c.(802-804)Ccc>Tcc	p.P268S	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.P132S|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.P268S			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	268					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CATCCCGGCTCCCCAGGGTAT	0.622000													31	95					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132161206	132161206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:132161206G>A	ENST00000378679.3	-	4	1431	c.627C>T	c.(625-627)gcC>gcT	p.A209A	SHROOM1_ENST00000319854.3_Silent_p.A209A|SHROOM1_ENST00000378676.1_Silent_p.A209A	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	209	ASD1.				actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACCCCGGCCGGCAGTTCCTG	0.771000													6	5					0	0	1	0	0
ALDOA	226	broad.mit.edu	37	16	30081507	30081507	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30081507C>T	ENST00000566897.1	+	12	2221	c.1069C>T	c.(1069-1071)Ctc>Ttc	p.L357F	ALDOA_ENST00000569798.1_3'UTR|ALDOA_ENST00000563060.2_Missense_Mutation_p.L357F|ALDOA_ENST00000338110.5_Missense_Mutation_p.L357F|ALDOA_ENST00000395248.1_Missense_Mutation_p.L411F|ALDOA_ENST00000564546.1_Missense_Mutation_p.L357F|ALDOA_ENST00000412304.2_Missense_Mutation_p.L357F|ALDOA_ENST00000564595.2_Missense_Mutation_p.L411F|ALDOA_ENST00000395240.3_Missense_Mutation_p.L361F|ALDOA_ENST00000569545.1_Missense_Mutation_p.L357F			P04075	ALDOA_HUMAN	aldolase A, fructose-bisphosphate	357					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	17						CAGCGAGTCCCTCTTCGTCTC	0.632000													23	88					0	0	1	0	0
NT5E	4907	broad.mit.edu	37	6	86181095	86181095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:86181095G>A	ENST00000257770.3	+	3	752	c.703G>A	c.(703-705)Ggt>Agt	p.G235S	NT5E_ENST00000369646.3_Missense_Mutation_p.G235S|NT5E_ENST00000369651.3_Missense_Mutation_p.G235S	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	235					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	GAAAGTGAGGGGTGTGGACGT	0.423000													26	48					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50684298	50684298	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50684298G>A	ENST00000355832.5	-	12	2423	c.2345C>T	c.(2344-2346)tCc>tTc	p.S782F	ERCC6_ENST00000542458.1_Missense_Mutation_p.S152F	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	782					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AACTTCTTTGGAATCAACGAA	0.378000								Direct reversal of damage;Nucleotide excision repair (NER)					21	76					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247737544	247737544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247737544G>A	ENST00000366491.2	+	7	705	c.208G>A	c.(208-210)Gag>Aag	p.E70K	RP11-978I15.10_ENST00000446347.1_RNA|GCSAML_ENST00000527084.1_Missense_Mutation_p.E58K|GCSAML_ENST00000463359.1_Missense_Mutation_p.E58K|RP11-978I15.10_ENST00000435333.1_RNA|GCSAML_ENST00000366489.1_Missense_Mutation_p.E70K|GCSAML_ENST00000536561.1_Missense_Mutation_p.E70K|GCSAML_ENST00000366488.4_Missense_Mutation_p.E90K|GCSAML_ENST00000527541.1_Missense_Mutation_p.E58K					germinal center-associated, signaling and motility-like																		TGATGGCTATGAGAACATTGA	0.458000													25	70					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648064	112648064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:112648064G>A	ENST00000471858.1	-	3	656	c.424C>T	c.(424-426)Cat>Tat	p.H142Y	CD200R1_ENST00000490004.1_Missense_Mutation_p.H142Y|CD200R1_ENST00000308611.3_Missense_Mutation_p.H165Y|CD200R1_ENST00000440122.2_Missense_Mutation_p.H165Y|CD200R1_ENST00000295863.4_Missense_Mutation_p.H120Y	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	142	Ig-like C2-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TATCCACGATGGAAATTCCCA	0.438000													31	98					0	0	1	0	0
TP53TG3D	729264	broad.mit.edu	37	16	32264999	32264999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:32264999C>T	ENST00000398664.3	+	1	960	c.325C>T	c.(325-327)Cgg>Tgg	p.R109W	TP53TG3D_ENST00000354614.3_Missense_Mutation_p.R109W|RP11-56L13.7_ENST00000562604.1_RNA|TP53TG3D_ENST00000569631.1_Intron	NM_001243722.1	NP_001230651.1			TP53 target 3D																		AACAAAGGGTCGGTGGCCTCT	0.572000													20	100					0	0	1	0	0
ARIH2	10425	broad.mit.edu	37	3	49006032	49006032	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49006032C>T	ENST00000356401.4	+	7	943	c.604C>T	c.(604-606)Ccc>Tcc	p.P202S	ARIH2_ENST00000449376.1_Missense_Mutation_p.P202S|ARIH2_ENST00000490095.1_3'UTR	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	202					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		TCCATTGCTTCCCAATGAAGA	0.522000													60	152					0	0	1	0	0
RNASE7	84659	broad.mit.edu	37	14	21511371	21511371	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21511371G>A	ENST00000298690.4	+	2	477	c.220G>A	c.(220-222)Gag>Aag	p.E74K	NDRG2_ENST00000403829.3_Intron	NM_032572.3	NP_115961.2	Q9H1E1	RNAS7_HUMAN	ribonuclease, RNase A family, 7	74					defense response to bacterium|innate immune response	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	6	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;3.42e-11)|Epithelial(56;5.57e-09)|all cancers(55;2.36e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CTTCCTGCACGAGCCTTTCTC	0.542000													26	92					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8420714	8420714	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8420714G>A	ENST00000337907.3	-	19	3487	c.2853C>T	c.(2851-2853)ctC>ctT	p.L951L	RERE_ENST00000377464.1_Silent_p.L683L|RERE_ENST00000476556.1_Silent_p.L397L|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Silent_p.L951L	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	951	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGGGCCCCGAGAGGTGGGGAG	0.692000													18	51					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10942968	10942968	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10942968G>A	ENST00000298232.7	-	11	932	c.565C>T	c.(565-567)Cat>Tat	p.H189Y	TPTE_ENST00000361285.4_Missense_Mutation_p.H207Y|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.H169Y	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	207					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGAAACAGATGAAAAATTCTT	0.308000													7	74					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13922350	13922350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:13922350G>A	ENST00000265104.4	-	5	630	c.526C>T	c.(526-528)Ctc>Ttc	p.L176F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	176	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTGGCTCTGAGAGCAGGAATG	0.552000									Kartagener syndrome				19	47					0	0	1	0	0
E2F8	79733	broad.mit.edu	37	11	19253875	19253875	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:19253875G>A	ENST00000527884.1	-	7	1204	c.972C>T	c.(970-972)agC>agT	p.S324S	E2F8_ENST00000250024.4_Silent_p.S324S|RP11-428C19.4_ENST00000527978.1_RNA	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	324					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TAAGATCCAGGCTACTCAGAA	0.363000													56	131					0	0	1	0	0
RPL13A	23521	broad.mit.edu	37	19	49993505	49993505	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49993505C>T	ENST00000391857.4	+	3	181	c.105C>T	c.(103-105)gtC>gtT	p.V35V	RPL13A_ENST00000477613.2_3'UTR	NM_001270491.1|NM_012423.3	NP_001257420.1|NP_036555.1	P40429	RL13A_HUMAN	ribosomal protein L13a	35					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome			cervix(1)|endometrium(1)	2		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		AGGTGGTGGTCGTACGCTGTG	0.577000													18	39					0	0	1	0	0
FAM133A	286499	broad.mit.edu	37	X	92964424	92964424	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:92964424G>A	ENST00000538690.1	+	5	567	c.6G>A	c.(4-6)ggG>ggA	p.G2G	FAM133A_ENST00000332647.4_Silent_p.G2G|FAM133A_ENST00000355813.5_Silent_p.G2G|FAM133A_ENST00000322139.4_Silent_p.G2G	NM_001171110.1	NP_001164581.1	Q8N9E0	F133A_HUMAN	family with sequence similarity 133, member A	2										breast(2)|endometrium(2)|large_intestine(8)|lung(7)|upper_aerodigestive_tract(1)	20						GCACCATGGGGAAGCGGGATA	0.443000													11	14					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19745391	19745391	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19745391G>A	ENST00000203556.4	-	18	2146	c.2009C>T	c.(2008-2010)tCg>tTg	p.S670L	GMIP_ENST00000445806.2_Missense_Mutation_p.S641L|GMIP_ENST00000587238.1_Missense_Mutation_p.S644L|GMIP_ENST00000586269.1_Intron	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	670	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GGTCTTCAGCGAGCGGATAAC	0.602000													78	138					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53854576	53854576	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53854576G>A	ENST00000315251.5	-	6	1482	c.1045C>T	c.(1045-1047)Cct>Tct	p.P349S		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase	349					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	AGGGTGATAGGGCGGGTGCAT	0.552000													41	90					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176031	57176031	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:57176031G>A	ENST00000537055.2	-	2	767	c.536C>T	c.(535-537)tCg>tTg	p.S179L		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						CGCCAGGTACGAGCCCTGGCT	0.706000													9	20					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	78647157	78647157	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:78647157G>A	ENST00000286627.5	-	27	4356	c.3404C>T	c.(3403-3405)tCc>tTc	p.S1135F	KCNMA1_ENST00000404857.1_Missense_Mutation_p.S1176F|KCNMA1_ENST00000372443.1_Missense_Mutation_p.S1162F|KCNMA1_ENST00000286628.8_Missense_Mutation_p.S1193F|KCNMA1_ENST00000372440.1_Missense_Mutation_p.S1135F|KCNMA1_ENST00000354353.5_Missense_Mutation_p.S1196F|KCNMA1_ENST00000406533.3_Missense_Mutation_p.S1197F|KCNMA1_ENST00000404771.3_Missense_Mutation_p.S1193F	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	1193					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CGACGAGTGGGAGGAATGGGA	0.602000													23	64					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77661269	77661269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77661269G>A	ENST00000296043.6	+	5	2896	c.1943G>A	c.(1942-1944)gGc>gAc	p.G648D		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	648					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GAAGGCCTAGGCCAGAGCCTG	0.557000													48	108					0	0	1	0	0
PMP2	5375	broad.mit.edu	37	8	82357106	82357106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:82357106G>A	ENST00000256103.2	-	2	328	c.192C>T	c.(190-192)tcC>tcT	p.S64S	PMP2_ENST00000519260.1_Intron|RP11-157I4.4_ENST00000524085.2_RNA	NM_002677.3	NP_002668.1	P02689	MYP2_HUMAN	peripheral myelin protein 2	64						cytoplasm	cholesterol binding|fatty acid binding|transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			Epithelial(68;0.186)			CTAGCTTGAAGGAGATTTCTG	0.393000													9	78					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225639752	225639752	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:225639752G>A	ENST00000409592.3	-	52	5978	c.5865C>T	c.(5863-5865)atC>atT	p.I1955I	DOCK10_ENST00000258390.7_Silent_p.I1961I			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1961	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TCCGGTCTTCGATTTCCTTTT	0.507000													16	44					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52323898	52323898	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:52323898C>T	ENST00000356297.4	-	16	2074	c.1974G>A	c.(1972-1974)atG>atA	p.M658I	PXDNL_ENST00000543296.1_Missense_Mutation_p.M658I	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	658					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGCTCTTGCCATTTCCACAA	0.498000													10	14					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651391	1651391	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1651391G>A	ENST00000399676.2	+	1	359	c.321G>A	c.(319-321)ggG>ggA	p.G107G		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	107	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGTCCAAGGGGGCCTGTGGCT	0.687000													53	111					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756928	248756928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248756928G>A	ENST00000330500.2	-	1	172	c.142C>T	c.(142-144)Ctg>Ttg	p.L48L		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGTGGATCAGAAGTATCAAT	0.418000													29	80					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51173332	51173332	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:51173332C>T	ENST00000440970.1	-	2	2941	c.2510G>A	c.(2509-2511)aGc>aAc	p.S837N	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.S934N|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	934					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTCCTGCGTGCTGTTGGACGG	0.557000													9	65					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127561577	127561577	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:127561577A>G	ENST00000373580.3	+	4	476	c.476A>G	c.(475-477)aAc>aGc	p.N159S		NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	159										endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						ATCAAGGCCAACCTGAGCCGG	0.582000													15	56					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993086	28993086	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28993086C>T	ENST00000359747.4	+	15	2737	c.2708C>T	c.(2707-2709)aCt>aTt	p.T903I	DSG4_ENST00000308128.4_Missense_Mutation_p.T884I|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	884					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TCAGGATTGACTCCCTCAGAA	0.428000													53	119					0	0	1	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65715015	65715015	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65715015G>A	ENST00000532620.1	+	0	950							Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein											endometrium(2)|kidney(3)|lung(9)	14						CGCCCCAGGAGGGGGTCGATC	0.632000													16	43					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38574572	38574572	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38574572C>T	ENST00000356264.2	-	2	324	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	AMPH_ENST00000428293.2_Missense_Mutation_p.E37K|AMPH_ENST00000325590.5_Missense_Mutation_p.E37K	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	37	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						TCGAACTGTTCGTCTTTTGTC	0.348000													8	95					0	0	1	0	0
CDK20	23552	broad.mit.edu	37	9	90584785	90584785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90584785G>A	ENST00000375883.3	-	5	856	c.550C>T	c.(550-552)Ccg>Tcg	p.P184S	CDK20_ENST00000375871.4_Intron|CDK20_ENST00000336654.5_Missense_Mutation_p.P197S|CDK20_ENST00000605159.1_Missense_Mutation_p.P184S|CDK20_ENST00000325303.8_Missense_Mutation_p.P205S	NM_001170639.1|NM_012119.4|NM_178432.3	NP_001164110.1|NP_036251.2|NP_848519.1	Q8IZL9	CDK20_HUMAN	cyclin-dependent kinase 20	205	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						TTCTTGCCCGGGAAAAGGGGG	0.577000													7	73					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184299059	184299059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184299059G>A	ENST00000330394.2	+	15	3203	c.2751G>A	c.(2749-2751)ctG>ctA	p.L917L	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	917						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGCCCCTCCTGGACCGCACGG	0.577000													45	110					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349971	100349971	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100349971C>T	ENST00000542585.1	+	0	2391				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCCACCATCCCCACAGAAAAA	0.522000													28	61					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588480	20588480	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20588480G>A	ENST00000428453.1	-	0	4270																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GTGTCCCCAGGACACCATCAA	0.488000													7	23					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192700901	192700901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:192700901G>A	ENST00000304141.4	-	2	1355	c.1026C>T	c.(1024-1026)ctC>ctT	p.L342L		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	342						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GAGCGCTGGCGAGGGACGCTT	0.557000													42	121					0	0	1	0	0
SPTBN1	6711	broad.mit.edu	37	2	54856572	54856572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:54856572C>T	ENST00000333896.5	+	13	2647	c.2262C>T	c.(2260-2262)gtC>gtT	p.V754V	SPTBN1_ENST00000356805.4_Silent_p.V767V	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	767					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			TCAAGATTGTCTCCAGCAGCG	0.562000													22	67					0	0	1	0	0
VMO1	284013	broad.mit.edu	37	17	4688690	4688690	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4688690C>T	ENST00000328739.5	-	3	655	c.576G>A	c.(574-576)ctG>ctA	p.L192L	VMO1_ENST00000416307.2_3'UTR|VMO1_ENST00000441199.2_3'UTR|VMO1_ENST00000354194.4_3'UTR	NM_182566.2	NP_872372.1	Q7Z5L0	VMO1_HUMAN	vitelline membrane outer layer 1 homolog (chicken)	192					vitelline membrane formation	extracellular region				kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|pancreas(1)	11						GCGCGTCGTTCAGCGCAGTGT	0.642000													19	21					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102470966	102470966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:102470966C>T	ENST00000360184.4	+	24	5159	c.4995C>T	c.(4993-4995)atC>atT	p.I1665I		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	1665	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CGAGCATCATCCTGAACGAGG	0.378000													25	54					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067484	9067484	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9067484G>A	ENST00000397910.4	-	3	20165	c.19962C>T	c.(19960-19962)tcC>tcT	p.S6654S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6656	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATGAGCCAGGGAGAATGTTG	0.502000													33	71					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94878997	94878997	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:94878997G>A	ENST00000358746.2	-	5	423	c.125C>T	c.(124-126)gCc>gTc	p.A42V		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	42							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						AAAAACCCAGGCATTATAGTT	0.353000													16	127					0	0	1	0	0
SHC4	399694	broad.mit.edu	37	15	49160046	49160046	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:49160046G>A	ENST00000332408.4	-	6	1343	c.915C>T	c.(913-915)gcC>gcT	p.A305A	SHC4_ENST00000396535.3_Silent_p.A62A|SHC4_ENST00000537958.1_Silent_p.A19A	NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	305	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TAGCTACGTAGGCAACATAGT	0.323000													15	89					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26462936	26462936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26462936G>A	ENST00000265944.5	+	30	3909	c.3743G>A	c.(3742-3744)aGg>aAg	p.R1248K	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1248					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						ACAGAGGAGAGGAATTGTGAA	0.438000													17	70					0	0	1	0	0
SSX3	10214	broad.mit.edu	37	X	48213490	48213490	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:48213490C>T	ENST00000298396.2	-	4	276	c.224G>A	c.(223-225)cGg>cAg	p.R75Q	SSX3_ENST00000376893.3_Missense_Mutation_p.R75Q	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	75	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						GTCTGTGACCCGTTTATTACG	0.483000													16	100					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119750854	119750854	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:119750854G>A	ENST00000541757.1	+	17	1553	c.1173G>A	c.(1171-1173)agG>agA	p.R391R	MARCO_ENST00000327097.4_Silent_p.R469R			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	469	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						CCAAAGGAAGGGCCCTGTACA	0.542000													27	97					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140277573	140277573	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140277573G>A	ENST00000458420.3	+	12	2105	c.1915G>A	c.(1915-1917)Ggc>Agc	p.G639S		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	639					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CACCCTCCGGGGCACAGACCA	0.557000										HNSCC(16;0.037)			26	70					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39672164	39672164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:39672164C>T	ENST00000398930.1	+	4	1335	c.981C>T	c.(979-981)ttC>ttT	p.F327F	KCNJ15_ENST00000328656.3_Silent_p.F327F|KCNJ15_ENST00000398934.1_Silent_p.F327F|KCNJ15_ENST00000398932.1_Silent_p.F327F|KCNJ15_ENST00000398938.2_Silent_p.F327F			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	327					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						TGGCTGATTTCAGTCAGTTTG	0.443000													25	69					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10356180	10356180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10356180C>T	ENST00000255381.2	-	25	3291	c.3181G>A	c.(3181-3183)Ggt>Agt	p.G1061S	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1061					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTTAGGTCACCCTCCAGTTTT	0.343000													69	96					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106797653	106797653	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:106797653C>T	ENST00000276185.4	+	9	780	c.780C>T	c.(778-780)ctC>ctT	p.L260L	FRMPD3_ENST00000477796.1_3'UTR			Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	260	FERM.					cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						TGAAATGCCTCTTCCGAATAA	0.502000													5	14					0	0	1	0	0
OR11G2	390439	broad.mit.edu	37	14	20666274	20666274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20666274G>A	ENST00000357366.3	+	1	780	c.780G>A	c.(778-780)gtG>gtA	p.V260V		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTCTGGTCGTGAGAGCTGTGT	0.507000													51	251					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22155483	22155483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22155483C>T	ENST00000397126.4	-	4	2501	c.2353G>A	c.(2353-2355)Gct>Act	p.A785T	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CGGTTAAAAGCTTTGCCACAT	0.363000													22	57					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218940025	218940025	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:218940025G>A	ENST00000374155.3	+	8	1280	c.870G>A	c.(868-870)ggG>ggA	p.G290G	RUFY4_ENST00000344321.7_Silent_p.G270G|RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000463872.1_3'UTR			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	270							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGCCAGAAGGGAAGGAGCTTC	0.547000													4	12					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99060038	99060038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:99060038C>T	ENST00000357310.1	+	9	1842	c.1265C>T	c.(1264-1266)tCt>tTt	p.S422F	APAF1_ENST00000359972.2_Missense_Mutation_p.S411F|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000551964.1_Missense_Mutation_p.S422F|APAF1_ENST00000549007.1_Missense_Mutation_p.S422F|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000339433.3_Missense_Mutation_p.S422F|APAF1_ENST00000547045.1_Missense_Mutation_p.S422F|APAF1_ENST00000550527.1_Missense_Mutation_p.S411F	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	422					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	GTAAATAAGTCTCTTTTATTC	0.353000													40	96					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82807962	82807962	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82807962C>T	ENST00000265077.3	+	6	1354	c.789C>T	c.(787-789)ttC>ttT	p.F263F	VCAN_ENST00000342785.4_Silent_p.F263F|VCAN_ENST00000502527.2_Silent_p.F263F|VCAN_ENST00000343200.5_Silent_p.F263F|VCAN_ENST00000512590.2_Silent_p.F215F|VCAN_ENST00000513984.1_Silent_p.F263F	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	263	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AATTCACCTTCGAGGAGGCTG	0.488000													19	54					0	0	1	0	0
TRGV3	6976	broad.mit.edu	37	7	38398395	38398395	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38398395C>T	ENST00000390346.2	-	0	254																											ACTTCGTTCTCCCTTCCAAGT	0.438000													19	105					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240016749	240016749	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:240016749G>A	ENST00000345617.3	-	17	3013	c.2222C>T	c.(2221-2223)tCg>tTg	p.S741L	HDAC4_ENST00000541256.1_Missense_Mutation_p.S715L|HDAC4_ENST00000543185.1_Missense_Mutation_p.S325L	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	741	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GGAGGCGAGCGAGCCTGTGGG	0.617000													42	111					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178410187	178410187	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178410187G>A	ENST00000231188.5	-	9	2338	c.2160C>T	c.(2158-2160)ccC>ccT	p.P720P	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Silent_p.P720P	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	720					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CGCTGTGTGGGGGCCGGGCCC	0.602000													18	41					0	0	1	0	0
OR4S1	256148	broad.mit.edu	37	11	48328312	48328312	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48328312C>T	ENST00000319988.1	+	1	538	c.538C>T	c.(538-540)Cat>Tat	p.H180Y		NM_001004725.1	NP_001004725.1	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|skin(3)	21						CTGTGATGTTCATCCCCTGCT	0.493000													32	28					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	95001578	95001578	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:95001578C>T	ENST00000265627.5	-	4	284	c.274G>A	c.(274-276)Gaa>Aaa	p.E92K	PON3_ENST00000427422.1_Missense_Mutation_p.E92K|PON1_ENST00000542556.1_Intron	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			GGGTTTTGTTCATTCAGATCC	0.378000													24	83					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86392931	86392931	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:86392931G>A	ENST00000285379.5	+	7	926	c.696G>A	c.(694-696)ggG>ggA	p.G232G		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	232					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	ACTTCAATGGGGAGGGTGAAC	0.393000													23	45					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371608	240371608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240371608C>T	ENST00000319653.9	+	5	3726	c.3496C>T	c.(3496-3498)Ccc>Tcc	p.P1166S		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1166	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ACCCCCACCTCCCCCTCTACC	0.692000													16	22					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165867	172165867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:172165867C>T	ENST00000241256.2	-	1	379	c.337G>A	c.(337-339)Gac>Aac	p.D113N	GHSR_ENST00000427970.1_Missense_Mutation_p.D113N	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	113					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CAGAGGAGGTCGCCGAAGTTC	0.602000													13	33					0	0	1	0	0
ZNF534	147658	broad.mit.edu	37	19	52942175	52942175	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52942175C>T	ENST00000332323.6	+	4	1562	c.1501C>T	c.(1501-1503)Cat>Tat	p.H501Y	ZNF534_ENST00000433050.1_Missense_Mutation_p.H488Y|ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000432303.2_Intron	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						TAGGAAAATTCATACTGGAGA	0.403000													3	18					0	0	1	0	0
MOGAT2	80168	broad.mit.edu	37	11	75439890	75439890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:75439890C>T	ENST00000526712.1	+	4	1233	c.460C>T	c.(460-462)Ccc>Tcc	p.P154S	MOGAT2_ENST00000198801.5_Missense_Mutation_p.P236S			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	236					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					TGACCAGATTCCCAACTCTTC	0.532000													46	93					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83549998	83549998	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:83549998C>T	ENST00000296591.5	-	2	518	c.100G>A	c.(100-102)Gga>Aga	p.G34R	EDIL3_ENST00000380138.3_Missense_Mutation_p.G34R	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	34	EGF-like 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		CAGATACCTCCATTTTCACAT	0.393000													25	46					0	0	1	0	0
OR1D5	8386	broad.mit.edu	37	17	2966524	2966524	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:2966524G>A	ENST00000575751.1	-	1	377	c.378C>T	c.(376-378)acC>acT	p.T126T		NM_014566.1	NP_055381.1	P58170	OR1D5_HUMAN	olfactory receptor, family 1, subfamily D, member 5	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|lung(10)	11						GGGGGCAGCAGGTGGCCACAT	0.582000													22	37					0	0	1	0	0
TNFRSF1B	7133	broad.mit.edu	37	1	12253142	12253142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12253142C>T	ENST00000376259.3	+	6	863	c.774C>T	c.(772-774)ttC>ttT	p.F258F	TNFRSF1B_ENST00000492361.1_3'UTR	NM_001066.2	NP_001057.1	P20333	TNR1B_HUMAN	tumor necrosis factor receptor superfamily, member 1B	258					apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(1)|liver(1)|lung(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	CTGGCGACTTCGCTCTTCCAG	0.547000													4	30					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961963	34961963	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34961963C>T	ENST00000329357.5	+	1	1051	c.1015C>T	c.(1015-1017)Cat>Tat	p.H339Y		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	339										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCCCAACACTCATCGGGTGTC	0.587000													35	16					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96904252	96904252	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96904252G>A	ENST00000267584.4	+	6	734	c.690_splice	c.e6+1	p.K230_splice		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	230					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CATTTTTTAAGGTATGGCTTT	0.398000													6	64					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149428833	149428833	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:149428833C>T	ENST00000255992.10	+	17	2614	c.2215C>T	c.(2215-2217)Ctg>Ttg	p.L739L	KRBA1_ENST00000485033.2_Silent_p.L679L|KRBA1_ENST00000319551.8_Silent_p.L679L|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	740	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATCCAGAGGCCTGGAGCTTGG	0.587000													4	13					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183521816	183521816	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:183521816C>T	ENST00000305135.5	+	27	3819	c.3624C>T	c.(3622-3624)atC>atT	p.I1208I		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1208					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TACAAGAAATCCTGGAGAAGA	0.443000													56	92					0	0	1	0	0
FAM83A	84985	broad.mit.edu	37	8	124195392	124195392	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124195392C>T	ENST00000518448.1	+	2	2310	c.296C>T	c.(295-297)tCc>tTc	p.S99F	FAM83A_ENST00000522648.1_Missense_Mutation_p.S99F|FAM83A_ENST00000318462.6_Missense_Mutation_p.S99F|FAM83A_ENST00000276699.6_Missense_Mutation_p.S99F|FAM83A_ENST00000536633.1_Missense_Mutation_p.S99F|FAM83A_ENST00000546351.1_Missense_Mutation_p.S99F			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	99										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GACTCCAGCTCCCTACAGTCC	0.662000													11	103					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65909275	65909275	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:65909275C>T	ENST00000321892.4	+	13	5714	c.5653C>T	c.(5653-5655)Cct>Tct	p.P1885S	BPTF_ENST00000306378.6_Missense_Mutation_p.P1759S|BPTF_ENST00000335221.5_Missense_Mutation_p.P1885S|BPTF_ENST00000424123.3_Missense_Mutation_p.P1746S			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1885					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATATCCTTCTCCTAGACCGAC	0.373000													54	170					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74901259	74901259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74901259C>T	ENST00000569840.2	+	7	1273	c.699C>T	c.(697-699)ttC>ttT	p.F233F	MGAT5B_ENST00000301618.4_Silent_p.F233F|MGAT5B_ENST00000374998.3_3'UTR|MGAT5B_ENST00000428789.2_Silent_p.F244F	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	233						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGGCAGTTTTCCGAAGCAACC	0.637000													9	19					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67058534	67058534	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:67058534C>T	ENST00000295568.4	+	4	1584	c.1453C>T	c.(1453-1455)Cgt>Tgt	p.R485C	KBTBD8_ENST00000417314.2_Missense_Mutation_p.R511C|KBTBD8_ENST00000460576.1_Missense_Mutation_p.R69C	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	511										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		TAAATGGACTCGTAAGAAAGA	0.368000													34	99					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47432804	47432804	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47432804C>T	ENST00000285039.7	-	19	2698	c.2399G>A	c.(2398-2400)gGa>gAa	p.G800E		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	800	IQ 2.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GGCCAGGTGTCCCCGGCAGTA	0.582000													8	48					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839271	100839271	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100839271C>T	ENST00000223114.4	-	7	1148	c.982G>A	c.(982-984)Gaa>Aaa	p.E328K	MOGAT3_ENST00000379423.3_Missense_Mutation_p.G260E|MOGAT3_ENST00000440203.2_3'UTR	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	328					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					CCACAGCTTTCCTTGTGCTCC	0.647000													32	59					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42490132	42490132	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42490132C>T	ENST00000545399.1	-	6	682	c.529G>A	c.(529-531)Gaa>Aaa	p.E177K	ATP1A3_ENST00000602133.1_Missense_Mutation_p.E134K|ATP1A3_ENST00000543770.1_Missense_Mutation_p.E175K|ATP1A3_ENST00000302102.5_Missense_Mutation_p.E164K	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	164					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						TTCTCACCTTCCCGGATCACC	0.622000													31	119					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31318223	31318223	+	Missense_Mutation	SNP	G	G	A	rs146973182		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:31318223G>A	ENST00000380490.3	+	2	195	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	ALOX5AP_ENST00000479597.1_3'UTR	NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	33					cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		AGTGGAGCACGAAAGCAGGAC	0.498000													7	56					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236653459	236653459	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:236653459C>T	ENST00000409538.1	+	5	1805	c.1309C>T	c.(1309-1311)Cct>Tct	p.P437S	AGAP1_ENST00000428334.2_Missense_Mutation_p.P11S|AGAP1_ENST00000336665.5_Missense_Mutation_p.P172S|AGAP1_ENST00000409457.1_Missense_Mutation_p.P172S|AGAP1_ENST00000304032.7_Missense_Mutation_p.P172S			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	172	PH.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GAGCGAGATTCCTCTGGTTCT	0.433000													19	52					0	0	1	0	0
HOXC4	3221	broad.mit.edu	37	12	54448806	54448806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54448806C>T	ENST00000430889.2	+	2	658	c.612C>T	c.(610-612)ttC>ttT	p.F204F	HOXC4_ENST00000303406.4_Silent_p.F204F	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	204						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						AAATCTGGTTCCAAAACCGTC	0.567000													15	25					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52587970	52587970	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:52587970C>T	ENST00000395489.2	-	9	1065	c.669G>A	c.(667-669)gtG>gtA	p.V223V	A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000373993.1_Silent_p.V230V|A1CF_ENST00000282641.2_Silent_p.V230V|A1CF_ENST00000373997.3_Silent_p.V230V|A1CF_ENST00000374001.1_Silent_p.V230V|A1CF_ENST00000395495.1_Intron|A1CF_ENST00000373995.3_Silent_p.V238V	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	230					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ATAGGATTTTCACTGAAGACA	0.363000													26	79					0	0	1	0	0
NELFB	25920	broad.mit.edu	37	9	140151279	140151279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140151279C>T	ENST00000343053.4	+	4	707	c.370C>T	c.(370-372)Ccg>Tcg	p.P124S		NM_015456.3	NP_056271.2			negative elongation factor complex member B																		CATGTAGGTTCCGGAGAAAAA	0.582000													18	19					0	0	1	0	0
EFCAB5	374786	broad.mit.edu	37	17	28414151	28414151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:28414151C>T	ENST00000394835.3	+	19	3842	c.3650C>T	c.(3649-3651)cCt>cTt	p.P1217L	EFCAB5_ENST00000394832.2_Intron|EFCAB5_ENST00000320856.5_Missense_Mutation_p.P1093L	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	1217							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						CACAAAAATCCTCCTACCATC	0.418000													28	32					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62372641	62372641	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62372641G>A	ENST00000394773.2	-	16	2233	c.1926C>T	c.(1924-1926)ctC>ctT	p.L642L	EML3_ENST00000278845.4_Silent_p.L643L|EML3_ENST00000494176.2_Silent_p.L614L|EML3_ENST00000531557.1_Silent_p.L425L|EML3_ENST00000529309.1_Silent_p.L642L	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	642						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						AGTCAGCACAGAGACCAGTCT	0.562000													33	61					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14751223	14751223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14751223C>T	ENST00000284268.6	-	5	972	c.642G>A	c.(640-642)aaG>aaA	p.K214K	ANKH_ENST00000503939.1_5'UTR|ANKH_ENST00000535119.1_Silent_p.K16K	NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	214					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CGTGAATGTTCTTGTAGTAGC	0.562000													23	66					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317513	30317513	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:30317513C>T	ENST00000375377.1	-	3	1665	c.1564G>A	c.(1564-1566)Gca>Aca	p.A522T		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	522										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TGTCCCCTTGCCACACAGCGG	0.642000													44	130					0	0	1	0	0
INTS4	92105	broad.mit.edu	37	11	77639588	77639588	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:77639588G>A	ENST00000534064.1	-	11	1205	c.1171C>T	c.(1171-1173)Cgt>Tgt	p.R391C	INTS4_ENST00000525931.1_5'UTR|INTS4_ENST00000529807.1_Missense_Mutation_p.R391C	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	391					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			GCAGCAATACGAACCTCTAGA	0.493000													3	15					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49663097	49663097	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49663097C>T	ENST00000249601.4	-	6	1036	c.740G>A	c.(739-741)aGg>aAg	p.R247K	ARHGAP22_ENST00000435790.2_Missense_Mutation_p.R253K|ARHGAP22_ENST00000374170.1_Intron|ARHGAP22_ENST00000374172.1_Missense_Mutation_p.R138K|ARHGAP22_ENST00000417247.2_Missense_Mutation_p.R157K|ARHGAP22_ENST00000417912.2_Missense_Mutation_p.R263K	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	247	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GTCCTCGTACCTGGCGAAGGG	0.667000													6	22					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129279547	129279547	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:129279547C>T	ENST00000393239.1	-	30	5191	c.5013G>A	c.(5011-5013)gaG>gaA	p.E1671E	PLXND1_ENST00000324093.4_Silent_p.E1671E			Q9Y4D7	PLXD1_HUMAN	plexin D1	1671					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						GGAAATACTTCTCTGTGTCCA	0.512000													26	65					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876418	35876418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35876418C>T	ENST00000303115.3	+	8	1339	c.1210C>T	c.(1210-1212)Ctc>Ttc	p.L404F	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	404					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GTACCAGGACCTCCTGCTTAG	0.552000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						15	43					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38692558	38692558	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:38692558C>T	ENST00000222345.6	+	20	5550	c.5041C>T	c.(5041-5043)Ccg>Tcg	p.P1681S		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1681					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCCGGACATCCCGCCTGCACA	0.657000													16	46					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36322207	36322207	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36322207C>T	ENST00000378910.5	-	26	3377	c.3378G>A	c.(3376-3378)caG>caA	p.Q1126Q	NPHS1_ENST00000353632.6_Silent_p.Q1086Q	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	1126					cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCGTGGAGCTCTGAGTGTCCC	0.597000													29	73					0	0	1	0	0
OGFOD3	79701	broad.mit.edu	37	17	80361910	80361910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:80361910G>A	ENST00000313056.5	-	7	753	c.602C>T	c.(601-603)tCc>tTc	p.S201F	OGFOD3_ENST00000329197.5_Missense_Mutation_p.S201F	NM_024648.2|NM_175902.4	NP_078924.1|NP_787098.3			2-oxoglutarate and iron-dependent oxygenase domain containing 3																		ATGCAGCGAGGATGCGCTGAT	0.627000													4	8					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16875962	16875962	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16875962C>T	ENST00000524140.2	+	10	2787	c.2369C>T	c.(2368-2370)gCc>gTc	p.A790V	NWD1_ENST00000523826.1_Missense_Mutation_p.A584V|NWD1_ENST00000379808.3_Missense_Mutation_p.A790V|NWD1_ENST00000339803.6_Missense_Mutation_p.A655V|NWD1_ENST00000552788.1_Missense_Mutation_p.A790V|NWD1_ENST00000549814.1_Missense_Mutation_p.A790V	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	790							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GTCCGTGAAGCCCTCCAGCTC	0.617000													16	30					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130284070	130284070	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130284070C>T	ENST00000358511.6	+	3	925	c.894C>T	c.(892-894)aaC>aaT	p.N298N	COL6A6_ENST00000453409.2_Silent_p.N298N	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	298	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						ATATACAGAACCTTTCTCCCC	0.478000													19	84					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156816422	156816422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156816422G>A	ENST00000347377.6	+	29	3864	c.3433G>A	c.(3433-3435)Gag>Aag	p.E1145K	CYFIP2_ENST00000541131.1_Missense_Mutation_p.E1070K|CYFIP2_ENST00000318218.6_Missense_Mutation_p.E1170K|CYFIP2_ENST00000442283.2_3'UTR|CYFIP2_ENST00000521420.1_Missense_Mutation_p.E1119K|CYFIP2_ENST00000522463.1_Missense_Mutation_p.E949K|CYFIP2_ENST00000377576.3_Missense_Mutation_p.E1145K|CYFIP2_ENST00000435847.2_Missense_Mutation_p.E844K	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1170					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGGAACCAACGAGTTCACAGC	0.597000													5	16					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51902127	51902127	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:51902127G>A	ENST00000268919.4	+	1	1889	c.1733G>A	c.(1732-1734)aGg>aAg	p.R578K		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	578					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TCCCTTCAGAGGGATGAATTT	0.418000													32	63					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151304045	151304045	+	Silent	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151304045A>G	ENST00000370323.4	-	4	364	c.48T>C	c.(46-48)ctT>ctC	p.L16L	MAGEA10_ENST00000244096.3_Silent_p.L16L|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	16										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGGGATTGAAGATCTTCTT	0.572000													29	29					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77691837	77691837	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77691837G>A	ENST00000296043.6	+	10	6361	c.5408G>A	c.(5407-5409)aGc>aAc	p.S1803N	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1803	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GCGAAGGGGAGCCTGCTCACG	0.547000													26	88					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70840074	70840074	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:70840074G>A	ENST00000322773.4	+	18	1444	c.1341_splice	c.e18-1	p.G448_splice	COL19A1_ENST00000393344.1_Splice_Site_p.G70_splice	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	448	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TCACCCCTAGGGAAATGATGA	0.368000													13	28					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94519722	94519722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:94519722C>T	ENST00000375708.3	-	3	493	c.295G>A	c.(295-297)Gat>Aat	p.D99N	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	99	Ig-like C2-type.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						ACCGGGGCATCATTCTTTAGC	0.562000													35	105					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103032171	103032171	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103032171G>A	ENST00000306312.3	-	11	1392	c.1131C>T	c.(1129-1131)gcC>gcT	p.A377A	SLC26A5_ENST00000393723.1_Silent_p.A377A|SLC26A5_ENST00000393727.1_Silent_p.A377A|SLC26A5_ENST00000393729.1_Silent_p.A340A|SLC26A5_ENST00000393730.1_Silent_p.A377A|SLC26A5_ENST00000393735.2_Silent_p.A377A|SLC26A5_ENST00000356767.4_Intron|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000339444.6_Silent_p.A377A|SLC26A5_ENST00000432958.2_Silent_p.A377A	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	377					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						ACAGTCCCAGGGCAATGAGCT	0.438000													6	26					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325800	31325800	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:31325800G>A	ENST00000269197.5	+	12	5988	c.5988G>A	c.(5986-5988)atG>atA	p.M1996I		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1996					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding	p.K1997fs*4(1)		breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ATATGCCCATGAAAGAAGGTG	0.547000													10	128					0	0	1	0	0
WIPF3	644150	broad.mit.edu	37	7	29924037	29924037	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:29924037C>T	ENST00000409290.1	+	4	927	c.927C>T	c.(925-927)ccC>ccT	p.P309P	WIPF3_ENST00000409123.1_Silent_p.P309P|WIPF3_ENST00000242140.5_Silent_p.P309P	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	309										breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						CTTCTTTGCCCGCGCCCCCTT	0.687000													5	7					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735501	140735501	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140735501C>T	ENST00000571252.1	+	1	734	c.734C>T	c.(733-735)cCc>cTc	p.P245L	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCACTCAGCCCGAGTACCAC	0.537000													15	26					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36116684	36116684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36116684G>A	ENST00000296603.4	-	11	1776	c.1314C>T	c.(1312-1314)ttC>ttT	p.F438F		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	438						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGATGGAAAGGAAGCAGGCAA	0.338000													10	70					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52472087	52472087	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52472087G>A	ENST00000231721.2	-	14	1637	c.1638C>T	c.(1636-1638)tcC>tcT	p.S546S		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	546					multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		AGTGGGTACAGGAGGCACCAT	0.677000													10	29					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25322252	25322252	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25322252G>A	ENST00000549804.2	+	0	1243				SNORD116-12_ENST00000384468.1_RNA																							TAAAATGAATGAAAACTCTAT	0.428000													26	104					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44553214	44553214	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:44553214C>T	ENST00000289547.4	-	20	3967	c.3912G>A	c.(3910-3912)caG>caA	p.Q1304Q	NPC1L1_ENST00000381160.3_Silent_p.Q1277Q|NPC1L1_ENST00000546276.1_Silent_p.Q1231Q	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1304					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	CAGCCCGCTTCTGCTCCAGTG	0.597000													29	54					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130877827	130877827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:130877827C>T	ENST00000357462.5	-	1	355	c.262G>A	c.(262-264)Gac>Aac	p.D88N	POTEF_ENST00000360967.5_Missense_Mutation_p.D88N|POTEF_ENST00000361163.4_Missense_Mutation_p.D88N|POTEF_ENST00000409914.2_Missense_Mutation_p.D88N			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	88						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						ATAGCAGAGTCGTCGTGGTCT	0.617000													21	371					0	0	1	0	0
LYPD2	137797	broad.mit.edu	37	8	143831740	143831740	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:143831740C>T	ENST00000359228.3	-	3	421	c.339G>A	c.(337-339)ggG>ggA	p.G113G		NM_205545.1	NP_991108.1	Q6UXB3	LYPD2_HUMAN	LY6/PLAUR domain containing 2	113						anchored to membrane|plasma membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GCGTGAGGGCCCCGCAGTGGA	0.657000													3	4					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56639294	56639294	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56639294G>A	ENST00000267116.7	-	21	2392	c.2271C>T	c.(2269-2271)ccC>ccT	p.P757P		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	757							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						CCAGGTGAATGGGCGTGCGGC	0.622000													22	43					0	0	1	0	0
GABRG2	2566	broad.mit.edu	37	5	161524820	161524820	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:161524820G>A	ENST00000356592.3	+	4	964	c.504G>A	c.(502-504)agG>agA	p.R168R	GABRG2_ENST00000393933.4_Silent_p.R73R|GABRG2_ENST00000414552.2_Silent_p.R168R|GABRG2_ENST00000361925.4_Silent_p.R168R	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	168					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CCCCCAACAGGATGCTGAGAA	0.418000													34	85					0	0	1	0	0
ZBTB11	27107	broad.mit.edu	37	3	101390172	101390172	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:101390172G>A	ENST00000312938.4	-	3	1160	c.580C>T	c.(580-582)Cca>Tca	p.P194S	ZBTB11_ENST00000461821.1_3'UTR	NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						CAATGTTTTGGAGAAGAACGT	0.368000													50	151					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48318309	48318309	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48318309G>A	ENST00000435803.1	+	18	7542	c.7518G>A	c.(7516-7518)ttG>ttA	p.L2506L		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2506					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCATGCTGTTGAATGACAGTG	0.428000													27	243					0	0	1	0	0
E2F1	1869	broad.mit.edu	37	20	32264687	32264687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32264687C>T	ENST00000343380.5	-	7	1304	c.1165G>A	c.(1165-1167)Gag>Aag	p.E389K		NM_005225.2	NP_005216.1	Q01094	E2F1_HUMAN	E2F transcription factor 1	389	Transactivation.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding			NS(2)|breast(1)|endometrium(3)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	16						GAGAAGTCCTCCCGCACATGC	0.687000													3	6					0	0	1	0	0
TSPYL5	85453	broad.mit.edu	37	8	98289598	98289598	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:98289598C>T	ENST00000322128.3	-	1	578	c.475G>A	c.(475-477)Ggg>Agg	p.G159R		NM_033512.2	NP_277047.2	Q86VY4	TSYL5_HUMAN	TSPY-like 5	159					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	20	Breast(36;2.56e-06)					ACCTGAGGCCCCCTCCCCGCG	0.642000													48	112					0	0	1	0	0
MARCH8	220972	broad.mit.edu	37	10	45953750	45953750	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:45953750G>A	ENST00000453424.2	-	8	1920	c.1659C>T	c.(1657-1659)tcC>tcT	p.S553S	MARCH8_ENST00000395769.2_Silent_p.S271S|MARCH8_ENST00000476962.1_5'UTR|MARCH8_ENST00000319836.3_Silent_p.S271S|MARCH8_ENST00000395771.3_Silent_p.S271S			Q5T0T0	MARH8_HUMAN	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	271						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	12						AGTTTGTGTCGGAATGACAGA	0.393000													10	98					0	0	1	0	0
FUBP3	8939	broad.mit.edu	37	9	133488412	133488412	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:133488412C>T	ENST00000319725.9	+	5	419	c.344C>T	c.(343-345)tCa>tTa	p.S115L		NM_003934.1	NP_003925.1	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	115	KH 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		CAGATTGCTTCAGGTAAGGGC	0.373000													24	42					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32445998	32445998	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:32445998G>A	ENST00000266088.4	+	2	454	c.204G>A	c.(202-204)tgG>tgA	p.W68*		NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	68					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						TGGTGTGGTGGCCGGTAAGTT	0.453000													106	165					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75403345	75403345	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:75403345C>T	ENST00000297784.5	+	14	1515	c.975C>T	c.(973-975)atC>atT	p.I325I	TMC1_ENST00000340019.3_Silent_p.I325I|TMC1_ENST00000396237.3_Silent_p.I325I	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	325					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						ACTACCTGATCGGCAATCCTG	0.398000													21	55					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413859	48413859	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48413859C>T	ENST00000249598.1	-	2	1168	c.1009G>A	c.(1009-1011)Gag>Aag	p.E337K		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	337					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CCGATGTCCTCGAAGTTTACC	0.612000													28	80					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183675643	183675643	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183675643C>T	ENST00000511685.1	+	22	4246	c.4123C>T	c.(4123-4125)Cgc>Tgc	p.R1375C	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.R1375C					teneurin transmembrane protein 3									p.R1375C(1)									TCGTCAAGTTCGCATTGCTGC	0.493000													6	22					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58078924	58078924	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:58078924C>T	ENST00000219271.3	+	10	2369	c.1584C>T	c.(1582-1584)ttC>ttT	p.F528F		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	528	Hemopexin-like 4.				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						ACACCTACTTCTACAAGGGCA	0.587000													13	34					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1415401	1415401	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:1415401C>T	ENST00000446702.2	+	15	2527	c.1900C>T	c.(1900-1902)Cag>Tag	p.Q634*	CNTN6_ENST00000539053.1_Nonsense_Mutation_p.Q562*|CNTN6_ENST00000350110.2_Nonsense_Mutation_p.Q634*			Q9UQ52	CNTN6_HUMAN	contactin 6	634	Fibronectin type-III 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATTTACTATTCAGACTCGGAC	0.398000													39	86					0	0	1	0	0
ASMT	438	broad.mit.edu	37	X	1734132	1734132	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:1734132G>A	ENST00000381241.3	+	1	239	c.40G>A	c.(40-42)Gac>Aac	p.D14N	ASMT_ENST00000381233.3_Missense_Mutation_p.D14N|ASMT_ENST00000381229.4_Missense_Mutation_p.D14N	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	14					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTCCTTAATGACTACGCCAA	0.552000													4	3					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45284584	45284584	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45284584C>T	ENST00000270279.3	+	3	684	c.621C>T	c.(619-621)tcC>tcT	p.S207S	CBLC_ENST00000341505.4_Silent_p.S207S	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	207	Cbl-PTB.|EF-hand-like.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				GGCACGTGTCCATCTTCGAGT	0.607000			M		AML								30	77					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101488063	101488063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101488063G>A	ENST00000392979.3	+	17	1987	c.1626G>A	c.(1624-1626)acG>acA	p.T542T	ANO4_ENST00000550015.1_Silent_p.T97T|ANO4_ENST00000392977.3_Silent_p.T577T|ANO4_ENST00000299222.9_Silent_p.T97T	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	577						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TGCTTCTGACGAATTTAGGTG	0.328000										HNSCC(74;0.22)			26	56					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96937849	96937849	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96937849G>A	ENST00000267584.4	+	13	1436	c.1392G>A	c.(1390-1392)atG>atA	p.M464I		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	464	Adenylate kinase.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TTAGATTTATGAAAGAAAAGC	0.289000													22	52					0	0	1	0	0
CEACAM1	634	broad.mit.edu	37	19	43026203	43026203	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:43026203C>T	ENST00000161559.6	-	3	710	c.576G>A	c.(574-576)caG>caA	p.Q192Q	CEACAM1_ENST00000352591.5_Silent_p.Q192Q|LIPE-AS1_ENST00000457234.2_RNA|CEACAM1_ENST00000599389.1_Silent_p.Q192Q|LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA|CEACAM1_ENST00000351134.3_Intron|CEACAM1_ENST00000403444.3_Silent_p.Q192Q|CEACAM1_ENST00000403461.1_Silent_p.Q192Q|CEACAM1_ENST00000358394.3_Silent_p.Q192Q|CEACAM1_ENST00000308072.4_Silent_p.Q152Q	NM_001712.4	NP_001703.2	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	192	Ig-like C2-type 1.				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	17		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	CATTGGACAGCTGCAGCCTGG	0.532000													60	264					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55814181	55814181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55814181C>T	ENST00000309383.1	+	10	1251	c.974C>T	c.(973-975)tCa>tTa	p.S325L	BRSK1_ENST00000590333.1_Missense_Mutation_p.S341L|BRSK1_ENST00000326848.7_Missense_Mutation_p.S20L|BRSK1_ENST00000585418.1_Missense_Mutation_p.S325L	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	325	UBA.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		AGCATGGCATCACTGGGCTGC	0.682000													24	60					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108723676	108723676	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108723676C>T	ENST00000232603.5	-	20	2155	c.2073G>A	c.(2071-2073)ctG>ctA	p.L691L	MORC1_ENST00000483760.1_Silent_p.L670L	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	691					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						GGGCATTCTTCAGGCACCCTT	0.338000													106	311					0	0	1	0	0
LCN12	286256	broad.mit.edu	37	9	139847361	139847361	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139847361C>T	ENST00000371633.3	+	2	132	c.132C>T	c.(130-132)ttC>ttT	p.F44F		NM_178536.3	NP_848631.2	Q6JVE5	LCN12_HUMAN	lipocalin 12	44					lipid metabolic process	extracellular region	binding|transporter activity			endometrium(1)|kidney(1)|lung(1)|prostate(2)	5	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		GGGAATGGTTCGTCCTGGGCC	0.672000													61	130					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3139548	3139548	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3139548C>T	ENST00000252463.2	-	5	1809	c.1722G>A	c.(1720-1722)acG>acA	p.T574T	ZSCAN10_ENST00000575108.1_Silent_p.T235T|ZSCAN10_ENST00000538082.2_Silent_p.T492T	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	574					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						GCTTCTCGCCCGTGTGGCTGC	0.711000													3	10					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647777	51647777	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51647777C>T	ENST00000317643.6	+	2	617	c.548C>T	c.(547-549)tCc>tTc	p.S183F	SIGLEC7_ENST00000305628.7_Intron|SIGLEC7_ENST00000600577.1_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	183	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding	p.S183C(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		CCTATGATCTCCTGGATGGGG	0.652000													58	150					0	0	1	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134497252	134497252	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:134497252G>A	ENST00000372195.1	-	11	2079	c.1836C>T	c.(1834-1836)tcC>tcT	p.S612S	RAPGEF1_ENST00000372189.3_Silent_p.S595S|RAPGEF1_ENST00000372190.3_Silent_p.S613S			Q13905	RPGF1_HUMAN	Rap guanine nucleotide exchange factor (GEF) 1	595					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		CCCCACTGAAGGAGTCGCTGA	0.612000													6	15					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39934344	39934344	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:39934344C>T	ENST00000564288.1	+	96	22606	c.21829C>T	c.(21829-21831)Cgc>Tgc	p.R7277C	MACF1_ENST00000289893.4_Missense_Mutation_p.R5720C|MACF1_ENST00000567887.1_Missense_Mutation_p.R7314C|MACF1_ENST00000361689.2_Missense_Mutation_p.R5212C|MACF1_ENST00000539005.1_Missense_Mutation_p.R5082C|MACF1_ENST00000372915.3_Missense_Mutation_p.R7170C|MACF1_ENST00000317713.7_Missense_Mutation_p.R5212C|MACF1_ENST00000545844.1_Missense_Mutation_p.R5212C			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	7170	C-terminal tail (By similarity).|Ser-rich.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CGTGATGGTTCGCGTTGGTGG	0.433000													28	58					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182563248	182563248	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:182563248C>T	ENST00000323116.5	+	9	967	c.707C>T	c.(706-708)cCt>cTt	p.P236L	ATP11B_ENST00000482794.1_3'UTR	NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	236					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TTTCCTAGACCTCTGGGGCCG	0.333000													9	44					0	0	1	0	0
ZNF783	100289678	broad.mit.edu	37	7	148975505	148975505	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:148975505C>T	ENST00000434415.1	+	5	852	c.689C>T	c.(688-690)cCa>cTa	p.P230L	ZNF783_ENST00000489518.1_3'UTR	NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	230					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			CCTCCGTATCCAGAGCACCTC	0.607000													12	27					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600728	29600728	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:29600728C>T	ENST00000431530.3	+	1	1981	c.1923C>T	c.(1921-1923)ccC>ccT	p.P641P		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	631	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AAACTAAGCCCATCATTATGC	0.542000													4	37					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79748963	79748963	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79748963C>T	ENST00000305428.3	+	2	549	c.474C>T	c.(472-474)tgC>tgT	p.C158C		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	158						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CGTCCAAGTGCCGGAAGATGG	0.567000													21	71					0	0	1	0	0
ITPRIP	85450	broad.mit.edu	37	10	106075049	106075049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106075049C>T	ENST00000278071.2	-	3	1213	c.761G>A	c.(760-762)aGc>aAc	p.S254N	ITPRIP_ENST00000358187.2_Missense_Mutation_p.S254N|ITPRIP_ENST00000337478.1_Missense_Mutation_p.S254N	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	254						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						GCAGATGCAGCTCAATGTGTC	0.652000													17	41					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64967823	64967823	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:64967823C>G	ENST00000326648.3	+	4	2898	c.2770C>G	c.(2770-2772)Ctg>Gtg	p.L924V		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	924						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAGCCAGGCCCTGAAGACAAA	0.507000													16	193					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768863	57768863	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57768863C>T	ENST00000371030.2	+	1	2789	c.2789C>T	c.(2788-2790)tCt>tTt	p.S930F		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	930						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AGAGTGCTCTCTGCCCTGGCA	0.642000													27	58					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89160066	89160066	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89160066G>A	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA																							AGACAATAGTGAAAAATTACT	0.368000													16	41					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43252892	43252892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43252892G>A	ENST00000255226.6	+	17	3073	c.2257G>A	c.(2257-2259)Ggc>Agc	p.G753S	SLC14A2_ENST00000586448.1_Missense_Mutation_p.G753S|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A2_ENST00000589658.1_Missense_Mutation_p.G230S	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	753						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CGTTGGAATTGGCCAAGTGTA	0.478000													31	100					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26465770	26465770	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:26465770C>T	ENST00000265944.5	+	31	4600	c.4434C>T	c.(4432-4434)ctC>ctT	p.L1478L	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1478					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGCAGTGCCTCTCAGGTAAAA	0.388000													17	67					0	0	1	0	0
NCAPG2	54892	broad.mit.edu	37	7	158472759	158472759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:158472759G>A	ENST00000409339.3	-	11	1152	c.1039C>T	c.(1039-1041)Cga>Tga	p.R347*	NCAPG2_ENST00000275830.10_Nonsense_Mutation_p.R139*|NCAPG2_ENST00000356309.3_Nonsense_Mutation_p.R347*|NCAPG2_ENST00000409423.1_Nonsense_Mutation_p.R347*|NCAPG2_ENST00000449727.2_Nonsense_Mutation_p.R347*			Q86XI2	CNDG2_HUMAN	non-SMC condensin II complex, subunit G2	347					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	39	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		GCATTTGATCGAACTTCAGAG	0.363000													14	114					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7242219	7242219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7242219C>T	ENST00000542285.1	-	4	681	c.532G>A	c.(532-534)Ggc>Agc	p.G178S				P00736	C1R_HUMAN	complement component 1, r subcomponent	179	EGF-like; calcium-binding (Potential).				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGCTCATAGCCTGGACGGCAG	0.602000													23	93					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839269	15839269	+	Missense_Mutation	SNP	G	G	A	rs142766169	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15839269G>A	ENST00000305899.3	+	1	436	c.416G>A	c.(415-417)cGg>cAg	p.R139Q		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					ATGAGCCCACGGGGCTGCGCC	0.632000													25	63					0	0	1	0	0
LOC643711	643711	broad.mit.edu	37	12	98126997	98126997	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:98126997C>T	ENST00000550548.1	-	0	261					NR_077240.1																						CCTTGAATATCTTCCACTGCA	0.468000													12	17					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156642586	156642586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156642586G>A	ENST00000368223.3	-	4	1526	c.1394C>T	c.(1393-1395)tCc>tTc	p.S465F		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	465	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGTGCCAAGGAGGCATGGTC	0.627000													44	104					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121391559	121391559	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:121391559G>A	ENST00000260197.7	+	9	1533		c.e9+1		SORL1_ENST00000532451.1_Splice_Site	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing						cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CAATTGTGAGGTATTGATGCT	0.398000													11	24					0	0	1	0	0
MNS1	55329	broad.mit.edu	37	15	56726525	56726525	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:56726525C>T	ENST00000260453.3	-	8	1244	c.1080G>A	c.(1078-1080)ttG>ttA	p.L360L	TEX9_ENST00000352903.2_Intron|TEX9_ENST00000537232.1_Intron	NM_018365.2	NP_060835.1	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	360	Glu-rich.				meiosis					breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	20				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		CTAATTCCTTCAAGGCCATTT	0.338000													24	83					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133670172	133670172	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:133670172G>A	ENST00000310926.4	-	6	1014	c.741C>T	c.(739-741)gtC>gtT	p.V247V	SLCO2A1_ENST00000493729.1_Silent_p.V171V	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	247					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GGTCACCCGGGACCAAGTTAA	0.483000													29	62					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85989562	85989562	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:85989562C>T	ENST00000263360.6	+	12	2007	c.1321C>T	c.(1321-1323)Cga>Tga	p.R441*	EED_ENST00000528180.1_Nonsense_Mutation_p.R361*|EED_ENST00000327320.4_3'UTR|EED_ENST00000351625.6_Nonsense_Mutation_p.R466*|EED_ENST00000527888.1_Nonsense_Mutation_p.R106*	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	441	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GGATCGACTTCGATAAAATAC	0.383000													20	55					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43413570	43413570	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43413570C>T	ENST00000244533.3	+	13	3539	c.3180C>T	c.(3178-3180)tcC>tcT	p.S1060S	ABCC10_ENST00000372530.4_Silent_p.S1088S	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	1088	ABC transmembrane type-1 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			ACAGGGCCTCCTCACGGGAGC	0.667000													22	59					0	0	1	0	0
ENTPD2	954	broad.mit.edu	37	9	139944953	139944953	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139944953G>A	ENST00000355097.2	-	6	859	c.812C>T	c.(811-813)tCc>tTc	p.S271F	ENTPD2_ENST00000312665.5_Missense_Mutation_p.S271F	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	271						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CACTTGGGTGGAAAAGCCCCT	0.642000											OREG0019627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	22					0	0	1	0	0
TRIM24	8805	broad.mit.edu	37	7	138252230	138252230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:138252230C>T	ENST00000343526.4	+	10	1750	c.1535C>T	c.(1534-1536)cCg>cTg	p.P512L	TRIM24_ENST00000497516.1_3'UTR|TRIM24_ENST00000415680.2_Missense_Mutation_p.P478L			O15164	TIF1A_HUMAN	tripartite motif containing 24	512					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						TTCTAGCAACCGCCTCCACGT	0.348000													46	122					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103471420	103471420	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103471420C>T	ENST00000358392.2	-	18	2172	c.1855G>A	c.(1855-1857)Ggt>Agt	p.G619S	COL11A1_ENST00000370096.3_Missense_Mutation_p.G607S|COL11A1_ENST00000512756.1_Missense_Mutation_p.G491S|COL11A1_ENST00000353414.4_Missense_Mutation_p.G568S|COL11A1_ENST00000461720.1_5'UTR	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	607	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCTGGCAGACCCGGAAGTCCA	0.363000													23	123					0	0	1	0	0
TRBV7-7	28591	broad.mit.edu	37	7	142120058	142120058	+	RNA	SNP	C	C	T	rs141013676	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142120058C>T	ENST00000390377.1	-	0	108																											AGAGTTACATCCTGTCCCCTC	0.468000													7	56					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3174736	3174736	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:3174736C>T	ENST00000355072.5	+	31	4189	c.4044C>T	c.(4042-4044)tcC>tcT	p.S1348S		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1348					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TTGGCTCCTCCAGTGTGAGGC	0.587000													31	80					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27455990	27455990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:27455990G>A	ENST00000337929.3	+	6	1108	c.635G>A	c.(634-636)gGg>gAg	p.G212E	IL21R_ENST00000564583.1_3'UTR|IL21R_ENST00000395754.4_Missense_Mutation_p.G212E|IL21R_ENST00000564089.1_Missense_Mutation_p.G212E|IL21R_ENST00000395755.1_Missense_Mutation_p.G212E	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	212					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						TCCTACCAGGGGACCTGGAGT	0.582000			T	BCL6	NHL								21	86					0	0	1	0	0
TESC	54997	broad.mit.edu	37	12	117494630	117494630	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117494630G>A	ENST00000335209.7	-	3	376	c.190C>T	c.(190-192)Cgt>Tgt	p.R64C	TESC_ENST00000392545.4_Missense_Mutation_p.R117C|TESC_ENST00000541210.1_Intron			Q96BS2	TESC_HUMAN	tescalcin	64					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		AAGAAGGCACGAACAATTTTG	0.507000													57	32					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79434686	79434686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:79434686G>A	ENST00000554719.1	+	11	2511	c.2020G>A	c.(2020-2022)Gaa>Aaa	p.E674K	NRXN3_ENST00000335750.5_Missense_Mutation_p.E674K	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCGTGGCTGTGAAGGTACAAC	0.517000													25	47					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71690162	71690162	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71690162C>T	ENST00000356340.3	+	28	2040	c.1504C>T	c.(1504-1506)Cgc>Tgc	p.R502C	COL13A1_ENST00000398968.3_Missense_Mutation_p.R483C|COL13A1_ENST00000520133.1_Missense_Mutation_p.R451C|COL13A1_ENST00000398966.3_Missense_Mutation_p.R480C|COL13A1_ENST00000398969.3_Missense_Mutation_p.R445C|COL13A1_ENST00000398974.3_Missense_Mutation_p.R490C|COL13A1_ENST00000398972.3_Missense_Mutation_p.R502C|COL13A1_ENST00000398973.3_Missense_Mutation_p.R502C|COL13A1_ENST00000398971.3_Missense_Mutation_p.R502C|COL13A1_ENST00000520267.1_Missense_Mutation_p.R445C|COL13A1_ENST00000398964.3_Missense_Mutation_p.R473C|COL13A1_ENST00000357811.3_Missense_Mutation_p.R480C|COL13A1_ENST00000354547.3_Missense_Mutation_p.R480C|COL13A1_ENST00000517713.1_Missense_Mutation_p.R480C|COL13A1_ENST00000522165.1_Missense_Mutation_p.R483C|COL13A1_ENST00000398978.3_Missense_Mutation_p.R502C			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	502	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AAAGGGACCTCGCGGTAAACC	0.537000													11	25					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214178524	214178524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:214178524C>T	ENST00000366958.4	+	3	2350	c.1742C>T	c.(1741-1743)tCa>tTa	p.S581L	PROX1_ENST00000261454.4_Missense_Mutation_p.S581L|PROX1_ENST00000435016.1_Missense_Mutation_p.S581L|PROX1_ENST00000498508.2_Missense_Mutation_p.S581L	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	581					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GAAGGATTGTCACCCAATCAC	0.463000													24	64					0	0	1	0	0
AK1	203	broad.mit.edu	37	9	130630338	130630338	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130630338G>A	ENST00000373176.1	-	7	686	c.534C>T	c.(532-534)tcC>tcT	p.S178S	AK1_ENST00000373156.1_Silent_p.S178S|AK1_ENST00000223836.10_Silent_p.S194S|RP11-203J24.9_ENST00000476274.2_RNA	NM_000476.2	NP_000467.1	P00568	KAD1_HUMAN	adenylate kinase 1	178					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding			endometrium(1)|prostate(1)	2						CACTGTCCACGGAGCCCTCAG	0.672000													27	51					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55860969	55860969	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55860969C>T	ENST00000302124.2	+	1	217	c.186C>T	c.(184-186)ttC>ttT	p.F62F	OR8I2_ENST00000560768.1_Silent_p.F62F			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					TGTACTTTTTCCTGAGCAATT	0.383000													49	243					0	0	1	0	0
R3HDML	140902	broad.mit.edu	37	20	42969866	42969866	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42969866G>A	ENST00000217043.2	+	2	464	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K		NM_178491.2	NP_848586.1	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like	98						extracellular region	peptidase inhibitor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)	21		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CAGGGCTGCCGAAGCCTGGGC	0.587000													21	49					0	0	1	0	0
KLHDC1	122773	broad.mit.edu	37	14	50210498	50210498	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:50210498C>T	ENST00000359332.2	+	12	1099	c.1009C>T	c.(1009-1011)Caa>Taa	p.Q337*	KLHDC1_ENST00000554512.1_3'UTR	NM_172193.2	NP_751943.1	Q8N7A1	KLDC1_HUMAN	kelch domain containing 1	337						cytoplasm				kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	12	all_epithelial(31;0.00244)|Breast(41;0.00964)					ATTGATCTTTCAAACACAGCC	0.259000													15	46					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134992588	134992588	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:134992588C>T	ENST00000535938.1	+	16	2046	c.1879C>T	c.(1879-1881)Cac>Tac	p.H627Y	SAGE1_ENST00000370709.3_Missense_Mutation_p.H627Y|SAGE1_ENST00000537770.1_Missense_Mutation_p.H251Y|SAGE1_ENST00000324447.3_Missense_Mutation_p.H627Y	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	627										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					TGCAGTCACTCACAACATCCG	0.483000													27	51					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156378652	156378652	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:156378652G>A	ENST00000274532.2	-	3	606	c.550C>T	c.(550-552)Cag>Tag	p.Q184*	TIMD4_ENST00000407087.3_Nonsense_Mutation_p.Q184*	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	184	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTGTCATCTGGAGTGGTGTT	0.552000													39	125					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11300809	11300809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11300809C>T	ENST00000397056.1	+	3	277	c.86C>T	c.(85-87)cCc>cTc	p.P29L	HRH1_ENST00000431010.2_Missense_Mutation_p.P29L|HRH1_ENST00000438284.2_Missense_Mutation_p.P29L	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	29					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	CAGCTGATGCCCCTGGTGGTG	0.587000													13	31					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070360	9070360	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9070360C>T	ENST00000397910.4	-	3	17289	c.17086G>A	c.(17086-17088)Gag>Aag	p.E5696K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5698	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCAGTCTCTCCTGTGTGGGG	0.502000													20	55					0	0	1	0	0
RPL4	6124	broad.mit.edu	37	15	66795835	66795835	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:66795835G>A	ENST00000307961.6	-	2	128	c.36C>T	c.(34-36)tcC>tcT	p.S12S	RPL4_ENST00000568588.1_5'UTR	NM_000968.3	NP_000959.2	P36578	RL4_HUMAN	ribosomal protein L4	12					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)|urinary_tract(1)	17						CCCCCTTTTCGGAGTACACCG	0.428000													14	57					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	53975609	53975609	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53975609C>T	ENST00000312233.2	-	8	2016	c.1450G>A	c.(1450-1452)Ggg>Agg	p.G484R		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	484	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GGCTGGCCCCCCGGAGAATGG	0.692000													3	14					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	327976	327976	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:327976G>A	ENST00000264819.4	-	4	267	c.257C>T	c.(256-258)cCc>cTc	p.P86L	MIER2_ENST00000592722.1_5'UTR	NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCATCAAAGGGCATGTCGTT	0.617000													14	20					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420813	53420813	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:53420813G>A	ENST00000377942.3	-	1	1962	c.1759C>T	c.(1759-1761)Cct>Tct	p.P587S	PCDH8_ENST00000338862.4_Missense_Mutation_p.P587S	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	587	Cadherin 5.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GAAAGCTGAGGGGAGCCGCCG	0.652000													4	14					0	0	1	0	0
EMID1	129080	broad.mit.edu	37	22	29630153	29630153	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:29630153G>A	ENST00000334018.6	+	11	1182	c.994G>A	c.(994-996)Gga>Aga	p.G332R	EMID1_ENST00000404755.3_Intron|EMID1_ENST00000404820.3_Missense_Mutation_p.G332R	NM_001267895.1|NM_133455.3	NP_001254824.1|NP_597712.2	Q96A84	EMID1_HUMAN	EMI domain containing 1	330	Collagen-like.					collagen				NS(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(2)|skin(3)	12						TGGACCCAAAGGAATCTCTGG	0.642000													5	12					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152319619	152319619	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:152319619C>T	ENST00000243326.4	+	29	4068	c.3585C>T	c.(3583-3585)ttC>ttT	p.F1195F	RIF1_ENST00000444746.2_Silent_p.F1195F|RIF1_ENST00000430328.2_Silent_p.F1195F|RIF1_ENST00000453091.2_Silent_p.F1195F|RIF1_ENST00000428287.2_Silent_p.F1195F			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1195					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AAAATTCTTTCGTTGTCAGCA	0.368000													37	75					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21120489	21120489	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21120489C>T	ENST00000377122.4	-	15	1869	c.1473G>A	c.(1471-1473)gaG>gaA	p.E491E	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	491					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TAATTTCAGTCTCCAGATCTC	0.428000													25	52					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204588113	204588113	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204588113C>T	ENST00000367175.1	-	1	3220	c.1008G>A	c.(1006-1008)caG>caA	p.Q336Q	LRRN2_ENST00000367176.3_Silent_p.Q336Q|LRRN2_ENST00000367177.3_Silent_p.Q336Q			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	336					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GGGTCTCCATCTGGGGCAGGT	0.612000													6	26					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167284402	167284402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:167284402C>T	ENST00000409855.1	-	17	2875	c.2749G>A	c.(2749-2751)Gga>Aga	p.G917R		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	917					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CAGATTTTTCCTTTCTTGGAT	0.408000													11	47					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301489	11301489	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11301489C>T	ENST00000397056.1	+	3	957	c.766C>T	c.(766-768)Ccc>Tcc	p.P256S	HRH1_ENST00000431010.2_Missense_Mutation_p.P256S|HRH1_ENST00000438284.2_Missense_Mutation_p.P256S	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	256					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GAAGGAGTCTCCCTGGGAGGT	0.527000													20	34					0	0	1	0	0
ACAP1	9744	broad.mit.edu	37	17	7245290	7245290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7245290C>T	ENST00000158762.3	+	3	341	c.135C>T	c.(133-135)ctC>ctT	p.L45L		NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	45	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						GCACTGGTCTCCTGGAAAGTG	0.612000													30	51					0	0	1	0	0
DDX55	57696	broad.mit.edu	37	12	124090660	124090660	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124090660T>A	ENST00000238146.4	+	3	250	c.200T>A	c.(199-201)aTc>aAc	p.I67N	DDX55_ENST00000538744.1_Missense_Mutation_p.I67N	NM_020936.1	NP_065987.1	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	67	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		GTCATCCCCATCCTGGAAATT	0.423000													13	46					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140389325	140389325	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140389325G>A	ENST00000532602.1	+	4	3689	c.2656G>A	c.(2656-2658)Gac>Aac	p.D886N	PCDHA6_ENST00000527624.1_Missense_Mutation_p.D622N|PCDHA12_ENST00000398631.2_Missense_Mutation_p.D877N|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Missense_Mutation_p.D899N|PCDHA6_ENST00000529310.1_Missense_Mutation_p.D886N|PCDHA1_ENST00000394633.3_Missense_Mutation_p.D622N|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Missense_Mutation_p.D884N|PCDHA8_ENST00000531613.1_Missense_Mutation_p.D886N|PCDHA13_ENST00000289272.2_Missense_Mutation_p.D886N|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Missense_Mutation_p.D885N|PCDHA1_ENST00000504120.2_Missense_Mutation_p.D886N|PCDHAC2_ENST00000289269.5_Missense_Mutation_p.D943N|PCDHA3_ENST00000522353.2_Missense_Mutation_p.D886N|PCDHA10_ENST00000506939.2_Missense_Mutation_p.D621N|PCDHA2_ENST00000526136.1_Missense_Mutation_p.D884N|PCDHA7_ENST00000525929.1_Missense_Mutation_p.D873N|PCDHA4_ENST00000530339.1_Missense_Mutation_p.D883N|PCDHA5_ENST00000529859.1_Missense_Mutation_p.D872N	NM_031857.1	NP_114063.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGTTGCCCGACAAATTCAT	0.507000													8	97					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284752	52284752	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52284752C>T	ENST00000301190.6	+	5	1249	c.1022C>T	c.(1021-1023)tCc>tTc	p.S341F	ANKRD33_ENST00000538991.1_Missense_Mutation_p.S147F|ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Missense_Mutation_p.S216F	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	216										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CGAAGCAAGTCCGTGCCAGAG	0.662000													10	27					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126153184	126153184	+	Missense_Mutation	SNP	G	G	A	rs141942694	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126153184G>A	ENST00000393425.1	+	15	1690	c.1591G>A	c.(1591-1593)Gag>Aag	p.E531K	CCDC37_ENST00000505024.1_Missense_Mutation_p.E531K|CCDC37_ENST00000352312.1_Missense_Mutation_p.E530K|CCDC37_ENST00000506204.1_3'UTR			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	530										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		GGTCAAGATCGAGCAGGCCGA	0.637000													14	53					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55910724	55910724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55910724G>A	ENST00000388975.3	-	5	585	c.469C>T	c.(469-471)Cgc>Tgc	p.R157C		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	157					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ACGTGGACGCGAGAATCATGG	0.398000													9	13					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169940013	169940013	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:169940013C>T	ENST00000327239.4	+	6	1992	c.488C>T	c.(487-489)tCc>tTc	p.S163F	DHRS9_ENST00000428522.1_Missense_Mutation_p.S163F|DHRS9_ENST00000412271.1_Missense_Mutation_p.S163F|DHRS9_ENST00000357546.2_Missense_Mutation_p.S163F|DHRS9_ENST00000421653.1_Missense_Mutation_p.S16F|DHRS9_ENST00000602501.1_Missense_Mutation_p.S163F|DHRS9_ENST00000436483.2_Missense_Mutation_p.S163F|DHRS9_ENST00000432060.2_Missense_Mutation_p.S223F	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	163					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						ATTAATGTCTCCAGTGTTGGA	0.418000													31	90					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48349722	48349722	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48349722G>A	ENST00000435803.1	+	24	9524	c.9500G>A	c.(9499-9501)cGa>cAa	p.R3167Q		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3167					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTGGATGTGCGAGCTTTCATT	0.512000													86	197					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170011071	170011071	+	Missense_Mutation	SNP	C	C	T	rs147817392		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:170011071C>T	ENST00000263816.3	-	66	12479	c.12194G>A	c.(12193-12195)cGa>cAa	p.R4065Q		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4065					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATTATATTTTCGAATTCGGAC	0.378000													16	93					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67109377	67109377	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67109377G>A	ENST00000284425.2	-	15	2201	c.2027C>T	c.(2026-2028)gCt>gTt	p.A676V		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	676	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CAGGATGTCAGCCTCATCCAT	0.483000													15	55					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55077389	55077389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55077389G>A	ENST00000302250.2	-	6	990	c.830C>T	c.(829-831)tCg>tTg	p.S277L	FAM151A_ENST00000371304.2_Missense_Mutation_p.S277L|ACOT11_ENST00000371316.3_Intron	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	277						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CATGGGGTCCGAGGCAGCCTG	0.592000													29	98					0	0	1	0	0
PGAP3	93210	broad.mit.edu	37	17	37844115	37844115	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37844115G>A	ENST00000300658.4	-	1	245	c.153C>T	c.(151-153)tcC>tcT	p.S51S	PGAP3_ENST00000579146.1_Silent_p.S51S|PGAP3_ENST00000429199.2_Silent_p.S51S|PGAP3_ENST00000378011.4_Silent_p.S51S	NM_033419.3	NP_219487.3	Q96FM1	PGAP3_HUMAN	post-GPI attachment to proteins 3	51					GPI anchor biosynthetic process	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	hydrolase activity, acting on ester bonds			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12						TTGGCTGGCGGGAGCGGAAGT	0.652000													4	6					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123489863	123489863	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123489863C>T	ENST00000280562.5	-	6	1081	c.876G>A	c.(874-876)ggG>ggA	p.G292G	PITPNM2_ENST00000320201.4_Silent_p.G292G|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000546049.1_Silent_p.G292G|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Silent_p.G292G			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	292					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CTAGGGGCTCCCCATTGCTGC	0.647000													26	52					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11078583	11078583	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11078583C>T	ENST00000287766.4	+	16	2152	c.1731C>T	c.(1729-1731)atC>atT	p.I577I	SLC6A1_ENST00000536032.1_Silent_p.I399I	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	577				I -> T (in Ref. 1; CAA38484).	neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	GCGAAGACATCGTTCGCCCAG	0.632000													30	71					0	0	1	0	0
PTPN3	5774	broad.mit.edu	37	9	112145801	112145801	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112145801G>A	ENST00000412145.1	-	18	4444	c.1891C>T	c.(1891-1893)Ccc>Tcc	p.P631S	PTPN3_ENST00000374541.2_Missense_Mutation_p.P762S|PTPN3_ENST00000394827.3_Missense_Mutation_p.P230S|PTPN3_ENST00000262539.3_Missense_Mutation_p.P608S|PTPN3_ENST00000446349.1_Missense_Mutation_p.P586S	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	762					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						ATGACGTCGGGGGGATCTGGC	0.557000													21	92					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43606198	43606198	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:43606198G>A	ENST00000360835.3	-	19	2558	c.2432C>T	c.(2431-2433)tCc>tTc	p.S811F		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	811	CUB.				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GTAGTTGGGGGACTCGATGTA	0.652000													14	36					0	0	1	0	0
CCDC121	79635	broad.mit.edu	37	2	27850325	27850325	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27850325C>T	ENST00000324364.3	-	2	522	c.342G>A	c.(340-342)aaG>aaA	p.K114K	ZNF512_ENST00000556601.1_Intron|CCDC121_ENST00000394775.3_Silent_p.K276K|RP11-158I13.2_ENST00000505973.1_RNA	NM_024584.4	NP_078860.2	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121	114										breast(1)|endometrium(3)|large_intestine(2)|lung(6)|prostate(2)	14	Acute lymphoblastic leukemia(172;0.155)					CCTGCTTTTCCTTTAATATAG	0.433000													90	230					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281937	152281937	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152281937C>T	ENST00000368799.1	-	3	5460	c.5425G>A	c.(5425-5427)Ggt>Agt	p.G1809S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1809	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGTCCTGACCCTCTTGGGAC	0.597000									Ichthyosis				128	543					0	0	1	0	0
FBXO43	286151	broad.mit.edu	37	8	101153442	101153442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101153442G>A	ENST00000428847.2	-	2	1356	c.1040C>T	c.(1039-1041)tCc>tTc	p.S347F		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	347					meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			GTCAGACAGGGAATCTTCTGA	0.443000													40	91					0	0	1	0	0
NACA2	342538	broad.mit.edu	37	17	59668441	59668441	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59668441G>A	ENST00000521764.1	-	1	122	c.101C>T	c.(100-102)tCa>tTa	p.S34L		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	34					protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					CCCTGGTACTGATTCACCACT	0.542000													36	86					0	0	1	0	0
ACD	65057	broad.mit.edu	37	16	67694195	67694195	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67694195G>A	ENST00000219251.8	-	1	518	c.187C>T	c.(187-189)Ccg>Tcg	p.P63S	ACD_ENST00000393919.4_Missense_Mutation_p.P63S	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	63					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCTTTCCTCGGAAGAGGAAGC	0.741000													5	35					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23926680	23926680	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:23926680C>T	ENST00000402377.3	-	4	1813	c.1672G>A	c.(1672-1674)Gga>Aga	p.G558R	ZNF681_ENST00000395385.3_Missense_Mutation_p.G489R	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	558					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				GGTTTCTCTCCAGTATGAATT	0.398000													9	107					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41554252	41554252	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41554252T>G	ENST00000396942.1	-	25	2760	c.2677A>C	c.(2677-2679)Agc>Cgc	p.S893R	ANK1_ENST00000352337.4_Missense_Mutation_p.S893R|ANK1_ENST00000396945.1_Missense_Mutation_p.S893R|ANK1_ENST00000289734.7_Missense_Mutation_p.S893R|ANK1_ENST00000379758.2_Missense_Mutation_p.S893R|ANK1_ENST00000265709.8_Missense_Mutation_p.S934R|ANK1_ENST00000347528.4_Missense_Mutation_p.S893R			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	893					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GTGGCCGGGCTGCTGGGGATG	0.647000													15	27					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156622703	156622703	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:156622703C>T	ENST00000361588.5	+	8	2002	c.1961C>T	c.(1960-1962)tCa>tTa	p.S654L	BCAN_ENST00000329117.4_Intron|RP11-284F21.7_ENST00000448869.1_RNA	NM_198427.1	NP_940819.1	Q96GW7	PGCB_HUMAN	brevican	418	EGF-like.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCCAAGGCTCAACTGCCCTC	0.597000													68	103					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874038	36874038	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36874038C>T	ENST00000301807.6	-	21	7151	c.5254G>A	c.(5254-5256)Gag>Aag	p.E1752K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E2302K|TRANK1_ENST00000428977.2_Missense_Mutation_p.E1752K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2302					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TTTTCAAACTCCTCCGGGTAG	0.527000													27	59					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10084865	10084865	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10084865G>A	ENST00000264828.3	-	47	3571	c.3486C>T	c.(3484-3486)gtC>gtT	p.V1162V		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1162	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CGACGTCTCCGACCTCCCCTT	0.592000													26	52					0	0	1	0	0
KITLG	4254	broad.mit.edu	37	12	88910219	88910219	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:88910219C>T	ENST00000347404.5	-	5	984	c.412G>A	c.(412-414)Gaa>Aaa	p.E138K	KITLG_ENST00000357116.4_Intron|KITLG_ENST00000228280.5_Missense_Mutation_p.E138K|KITLG_ENST00000378535.4_5'UTR	NM_003994.5	NP_003985.2	P21583	SCF_HUMAN	KIT ligand	138					cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)	9						AAGAATTCTTCAGGAGTAAAG	0.343000									Testicular Cancer, Familial Clustering of				12	68					0	0	1	0	0
POP4	10775	broad.mit.edu	37	19	30099604	30099604	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30099604C>T	ENST00000392279.3	+	2	69	c.29C>T	c.(28-30)aCt>aTt	p.T10I	POP4_ENST00000591824.1_3'UTR|POP4_ENST00000221770.3_5'UTR|POP4_ENST00000585603.1_Silent_p.D16D			O95707	RPP29_HUMAN	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)	0					mRNA cleavage|rRNA processing|tRNA processing	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease P activity|RNA binding			breast(1)|endometrium(1)|lung(4)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			AGGCGAATGACTCCGATGTCC	0.483000													11	127					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115341723	115341723	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115341723G>A	ENST00000351270.3	+	9	1023	c.927G>A	c.(925-927)agG>agA	p.R309R	HABP2_ENST00000542051.1_Silent_p.R283R|HABP2_ENST00000541666.1_Intron	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	309					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		TAGCAGAGAGGAAGATCAAGA	0.572000													45	122					0	0	1	0	0
TMEM177	80775	broad.mit.edu	37	2	120438714	120438714	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:120438714C>T	ENST00000424086.1	+	2	758	c.285C>T	c.(283-285)ttC>ttT	p.F95F	TMEM177_ENST00000409951.1_Intron|TMEM177_ENST00000272521.6_Silent_p.F95F|TMEM177_ENST00000496203.1_Intron|TMEM177_ENST00000401466.1_Silent_p.F95F	NM_001105198.1	NP_001098668.1	Q53S58	TM177_HUMAN	transmembrane protein 177	95						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	13	Colorectal(110;0.196)					GTGCAGGCTTCCCAAGACTCC	0.547000													111	235					0	0	1	0	0
EXD2	55218	broad.mit.edu	37	14	69702850	69702850	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:69702850C>T	ENST00000409014.1	+	8	1419	c.762C>T	c.(760-762)taC>taT	p.Y254Y	EXD2_ENST00000409242.1_Silent_p.Y254Y|EXD2_ENST00000409949.1_Silent_p.Y254Y|EXD2_ENST00000312994.5_Silent_p.Y379Y|EXD2_ENST00000449989.1_Silent_p.Y254Y|EXD2_ENST00000409018.3_Silent_p.Y379Y|EXD2_ENST00000409675.1_Silent_p.Y254Y|EXD2_ENST00000492815.1_3'UTR	NM_001193360.1	NP_001180289.1	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	254					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						CTCAGTGGTACCTGGACAAAG	0.468000													9	137					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086625	100086625	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100086625C>T	ENST00000423930.1	+	4	1440	c.1281C>T	c.(1279-1281)tcC>tcT	p.S427S	NYAP1_ENST00000300179.2_Silent_p.S427S|NYAP1_ENST00000454988.1_Silent_p.S370S			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	427	Pro-rich.																TCCCCAACTCCCACAGCATGA	0.746000													7	7					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50958925	50958925	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50958925C>T	ENST00000374103.4	-	7	941	c.856G>A	c.(856-858)Gag>Aag	p.E286K	OGDHL_ENST00000419399.1_Missense_Mutation_p.E229K|OGDHL_ENST00000432695.1_Missense_Mutation_p.E77K	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	286					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						ATCCCCATCTCGCTGGATTTG	0.582000													5	25					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35910613	35910613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35910613C>T	ENST00000397367.2	-	3	296	c.170G>A	c.(169-171)cGa>cAa	p.R57Q	CAPSL_ENST00000514524.1_Missense_Mutation_p.R57Q|CAPSL_ENST00000397366.1_Missense_Mutation_p.R57Q	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	57	EF-hand 1.					cytoplasm	calcium ion binding	p.R57Q(1)		central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			ATCAAGGGTTCGATTATTATC	0.308000													15	49					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169697037	169697037	+	Silent	SNP	C	C	T	rs144324234	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:169697037C>T	ENST00000333360.7	-	9	1450	c.1311G>A	c.(1309-1311)ccG>ccA	p.P437P	C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367775.1_Silent_p.P312P|SELE_ENST00000367774.1_Intron|SELE_ENST00000367782.4_Intron|SELE_ENST00000367779.4_Intron|SELE_ENST00000367781.4_Silent_p.P374P|SELE_ENST00000367777.1_Intron|SELE_ENST00000367776.1_Silent_p.P374P|SELE_ENST00000367780.4_Silent_p.P312P	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	437	Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					CCAAACCCTTCGGGGGCTGGT	0.488000													29	90					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228886491	228886491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228886491C>T	ENST00000392056.3	-	6	679	c.633G>A	c.(631-633)gaG>gaA	p.E211E	SPHKAP_ENST00000344657.5_Silent_p.E211E	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	211						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GAAAGTCTTCCTCGATTGAAG	0.473000													24	82					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31901450	31901450	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31901450A>T	ENST00000456570.1	+	3	375	c.320A>T	c.(319-321)cAt>cTt	p.H107L	CFB_ENST00000477310.1_Intron|C2_ENST00000442278.2_Missense_Mutation_p.H37L|C2_ENST00000452323.2_Missense_Mutation_p.H46L|C2_ENST00000469372.1_Start_Codon_SNP_p.M1L|C2_ENST00000299367.5_Missense_Mutation_p.H169L|CFB_ENST00000556679.1_Missense_Mutation_p.H107L|C2_ENST00000418949.2_Missense_Mutation_p.H169L			P00751	CFAB_HUMAN	complement factor B	183	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CGCTTTGGTCATGGGGACAAG	0.632000													24	70					0	0	1	0	0
C6orf15	29113	broad.mit.edu	37	6	31079984	31079984	+	Missense_Mutation	SNP	G	G	A	rs139732921		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31079984G>A	ENST00000259870.3	-	2	155	c.152C>T	c.(151-153)tCc>tTc	p.S51F		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	51										endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						GCCAGTGGAGGAAGGTTGTCC	0.567000													37	98					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197102708	197102708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197102708G>A	ENST00000367409.4	-	6	2447	c.2191C>T	c.(2191-2193)Ctt>Ttt	p.L731F	ASPM_ENST00000367408.1_5'UTR|ASPM_ENST00000294732.7_Missense_Mutation_p.L731F	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	731					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						ATTCCCAAAAGAAGAGTAGCA	0.338000													12	44					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46825952	46825952	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46825952G>A	ENST00000283296.7	-	17	3976	c.3688C>T	c.(3688-3690)Ctc>Ttc	p.L1230F	GPR116_ENST00000265417.7_Missense_Mutation_p.L1230F|GPR116_ENST00000456426.2_Missense_Mutation_p.L1088F|GPR116_ENST00000362015.4_Missense_Mutation_p.L1230F|GPR116_ENST00000545669.1_Missense_Mutation_p.L659F	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1230					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			CCCCAAGTGAGGCCCAAGAGT	0.507000													41	97					0	0	1	0	0
GPR52	9293	broad.mit.edu	37	1	174417609	174417609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:174417609C>T	ENST00000367685.2	+	1	398	c.360C>T	c.(358-360)atC>atT	p.I120I	RABGAP1L_ENST00000251507.4_Intron|RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000357444.6_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	120						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						TTGGATATATCATCTCAGTTC	0.428000													84	195					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961968	34961968	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:34961968G>A	ENST00000329357.5	+	1	1056	c.1020G>A	c.(1018-1020)cgG>cgA	p.R340R		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	340										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						ACACTCATCGGGTGTCCAGTT	0.587000													32	15					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184099748	184099748	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:184099748C>T	ENST00000204604.1	+	6	885	c.639C>T	c.(637-639)ttC>ttT	p.F213F	CHRD_ENST00000348986.3_Silent_p.F213F|EIF2B5_ENST00000444495.1_Intron|CHRD_ENST00000450923.1_Silent_p.F213F|CHRD_ENST00000482805.1_3'UTR	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	213	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGATCCGCTTCTCAGACTCCA	0.612000													14	28					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803538	142803538	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:142803538G>A	ENST00000423385.1	-	0	1427																											ATAGATGTTGGAATTCCTGAT	0.269000													18	288					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922731	24922731	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922731C>T	ENST00000329468.2	+	1	2191	c.1717C>T	c.(1717-1719)Cct>Tct	p.P573S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TGCGGTAGACCCTGAAGTAGT	0.463000													39	87					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43319621	43319621	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:43319621G>A	ENST00000321925.4	+	8	1172	c.940G>A	c.(940-942)Ggc>Agc	p.G314S	SLC14A1_ENST00000502059.2_Missense_Mutation_p.G206S|SLC14A1_ENST00000586142.1_Missense_Mutation_p.G314S|RP11-116O18.3_ENST00000589510.1_RNA|SLC14A1_ENST00000436407.3_Missense_Mutation_p.G370S|SLC14A1_ENST00000591541.1_Missense_Mutation_p.G18S|SLC14A1_ENST00000402943.2_Missense_Mutation_p.G209S|RP11-116O18.3_ENST00000586213.1_RNA|SLC14A1_ENST00000535474.1_Missense_Mutation_p.G182S|SLC14A1_ENST00000415427.3_Missense_Mutation_p.G370S|SLC14A1_ENST00000589700.1_Silent_p.L264L	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	314						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						CCTGGCTCTTGGCTGTGGTGA	0.537000													23	64					0	0	1	0	0
RXRG	6258	broad.mit.edu	37	1	165378827	165378827	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:165378827G>A	ENST00000359842.5	-	7	1316	c.1014C>T	c.(1012-1014)gcC>gcT	p.A338A		NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	338	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CAGCACTGTGGGCACTGCTCC	0.522000													13	29					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13584380	13584380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:13584380C>T	ENST00000606117.1	+	3	334	c.38C>T	c.(37-39)tCc>tTc	p.S13F	SIRT5_ENST00000379262.4_Missense_Mutation_p.S13F|SIRT5_ENST00000359782.3_Missense_Mutation_p.S13F|SIRT5_ENST00000397350.2_5'UTR	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	13					chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	CGATTGATTTCCCAGCTATAT	0.453000													45	103					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160100331	160100331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:160100331C>T	ENST00000361216.3	+	13	1860	c.1771C>T	c.(1771-1773)Cct>Tct	p.P591S	ATP1A2_ENST00000392233.3_Missense_Mutation_p.P591S|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	591					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TATGATTGACCCTCCCCGGGC	0.577000													26	75					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86416107	86416107	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86416107C>T	ENST00000361669.2	+	3	2098	c.999C>T	c.(997-999)ttC>ttT	p.F333F	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Silent_p.F205F|GRM3_ENST00000394720.2_Silent_p.F331F|GRM3_ENST00000439827.1_Silent_p.F333F	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	333					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TCCGCCAGTTCGACCGCTACT	0.627000													17	25					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29793396	29793396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29793396G>A	ENST00000269202.6	+	11	1500	c.1453G>A	c.(1453-1455)Gat>Aat	p.D485N	MEP1B_ENST00000581447.1_Missense_Mutation_p.D485N	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	485	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TGGAGCCAATGATGATCAATT	0.408000													17	27					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36940286	36940286	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36940286C>T	ENST00000262865.4	+	5	648	c.559C>T	c.(559-561)Caa>Taa	p.Q187*	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	187					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				GTGGCTGATCCAACTCTTCCA	0.498000													10	92					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3879555	3879555	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:3879555C>T	ENST00000315677.3	-	4	1109	c.514G>A	c.(514-516)Gag>Aag	p.E172K	DLGAP1_ENST00000584874.1_Missense_Mutation_p.E172K|DLGAP1_ENST00000581527.1_Missense_Mutation_p.E172K|DLGAP1_ENST00000515196.2_Missense_Mutation_p.E172K|DLGAP1-AS3_ENST00000577649.1_RNA	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	172					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.E172K(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GCCTGCGCCTCGTCAGGGCTG	0.711000													36	108					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168807887	168807887	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:168807887C>T	ENST00000464456.1	-	13	3911	c.2711G>A	c.(2710-2712)gGa>gAa	p.G904E	MECOM_ENST00000433243.2_Missense_Mutation_p.G914E|MECOM_ENST00000460814.1_Missense_Mutation_p.G904E|MECOM_ENST00000392736.3_Missense_Mutation_p.G913E|MECOM_ENST00000472280.1_Missense_Mutation_p.G914E|MECOM_ENST00000264674.3_Missense_Mutation_p.G978E|MECOM_ENST00000468789.1_Missense_Mutation_p.G913E|MECOM_ENST00000494292.1_Missense_Mutation_p.G1092E	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TGGTTCCTTTCCTGTTTTTCC	0.428000													64	149					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9010979	9010979	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:9010979G>A	ENST00000344836.4	-	7	953	c.755C>T	c.(754-756)tCg>tTg	p.S252L	USP7_ENST00000535863.1_Missense_Mutation_p.S153L|USP7_ENST00000381886.4_Missense_Mutation_p.S236L	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	252					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						GCTTTTAGACGAATCATCCCC	0.358000													47	96					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53547816	53547816	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53547816G>A	ENST00000371500.3	+	12	2253	c.1912G>A	c.(1912-1914)Gaa>Aaa	p.E638K	PODN_ENST00000395871.2_Missense_Mutation_p.E515K|RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000312553.5_Missense_Mutation_p.E657K	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	609					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ggaggaggaggaagaggaAAC	0.522000													14	19					0	0	1	0	0
CHEK1	1111	broad.mit.edu	37	11	125513759	125513759	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:125513759C>T	ENST00000534070.1	+	9	1142	c.887C>T	c.(886-888)tCc>tTc	p.S296F	CHEK1_ENST00000524737.1_Missense_Mutation_p.S296F|CHEK1_ENST00000532449.1_3'UTR|CHEK1_ENST00000428830.2_Missense_Mutation_p.S296F|CHEK1_ENST00000544373.1_Missense_Mutation_p.S296F|CHEK1_ENST00000427383.2_Missense_Mutation_p.S312F|CHEK1_ENST00000278916.3_Missense_Mutation_p.S296F|CHEK1_ENST00000438015.1_Missense_Mutation_p.S296F	NM_001274.5	NP_001265.2	O14757	CHK1_HUMAN	checkpoint kinase 1	296					cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|endometrium(3)|large_intestine(2)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	26	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		CACATTCAATCCAATTTGGAC	0.383000								Other conserved DNA damage response genes					17	54					0	0	1	0	0
ARHGDIG	398	broad.mit.edu	37	16	332780	332780	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:332780G>A	ENST00000219409.3	+	6	719	c.644G>A	c.(643-645)tGg>tAg	p.W215*		NM_001176.3	NP_001167.2	Q99819	GDIR3_HUMAN	Rho GDP dissociation inhibitor (GDI) gamma	215					negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity			breast(1)|central_nervous_system(1)|large_intestine(1)	3		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				TCCTGGGAGTGGGGTCTCTGC	0.652000											OREG0003697	type=REGULATORY REGION|Gene=PDIA2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	4	10					0	0	1	0	0
DNM1	1759	broad.mit.edu	37	9	130982538	130982538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130982538G>A	ENST00000341179.7	+	6	859	c.767G>A	c.(766-768)cGa>cAa	p.R256Q	DNM1_ENST00000475805.1_Missense_Mutation_p.R256Q|DNM1_ENST00000486160.1_Missense_Mutation_p.R256Q|DNM1_ENST00000372923.3_Missense_Mutation_p.R256Q|DNM1_ENST00000393594.3_Missense_Mutation_p.R256Q	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	256					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity	p.R256L(2)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						GCTGCTGAACGAAAGTTCTTC	0.547000													61	100					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35993899	35993899	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:35993899G>A	ENST00000297866.5	+	15	2648	c.2582G>A	c.(2581-2583)cGa>cAa	p.R861Q		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	861										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TTGAGACCACGAGGCTTCTTC	0.433000													54	84					0	0	1	0	0
ZNF618	114991	broad.mit.edu	37	9	116779058	116779058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116779058C>T	ENST00000288466.7	+	10	901	c.802C>T	c.(802-804)Ccc>Tcc	p.P268S	ZNF618_ENST00000374126.5_Missense_Mutation_p.P280S	NM_133374.2	NP_588615.2	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	360					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|lung(10)|urinary_tract(1)	16						CTTACACGCCCCCATCAGTGA	0.577000													8	14					0	0	1	0	0
HOXD9	3235	broad.mit.edu	37	2	176988257	176988257	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:176988257C>T	ENST00000249499.6	+	1	1170	c.761C>T	c.(760-762)tCg>tTg	p.S254L	HOXD-AS2_ENST00000440016.2_RNA	NM_014213.3	NP_055028.3	P28356	HXD9_HUMAN	homeobox D9	254						nucleus	sequence-specific DNA binding			endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CCAGGCTGTTCGCTGAAGGAG	0.627000													13	14					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3139136	3139136	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3139136G>A	ENST00000252463.2	-	5	2221	c.2134C>T	c.(2134-2136)Ctg>Ttg	p.L712L	ZSCAN10_ENST00000575108.1_Silent_p.L373L|ZSCAN10_ENST00000538082.2_Silent_p.L630L	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	712					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						TGGCGCAGCAGGTGGGAGTTG	0.711000													5	10					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36179516	36179516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36179516C>T	ENST00000303965.4	-	9	2279	c.1790G>A	c.(1789-1791)aGa>aAa	p.R597K		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	597	PH 2.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTTATAGCCTCTCAATTCAAG	0.398000													17	100					0	0	1	0	0
FBXO22	26263	broad.mit.edu	37	15	76205550	76205550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:76205550C>T	ENST00000308275.3	+	3	391	c.286C>T	c.(286-288)Cgc>Tgc	p.R96C	FBXO22_ENST00000540507.1_5'UTR|FBXO22_ENST00000453211.2_Missense_Mutation_p.R96C	NM_147188.2	NP_671717.1	Q8NEZ5	FBX22_HUMAN	F-box protein 22	96					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						GCAGAATGTTCGCATCTTACC	0.383000													19	110					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161116026	161116026	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:161116026G>A	ENST00000523217.1	+	4	509	c.267G>A	c.(265-267)gaG>gaA	p.E89E	GABRA6_ENST00000274545.5_Silent_p.E99E|RP11-348M17.2_ENST00000521984.1_RNA	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	99					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGCCAACTGAGATTCTGAGTC	0.413000										TCGA Ovarian(5;0.080)			33	108					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38296443	38296443	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:38296443C>T	ENST00000553443.1	+	29	5170	c.5170C>T	c.(5170-5172)Cat>Tat	p.H1724Y	TTC6_ENST00000476979.1_Missense_Mutation_p.H358Y|TTC6_ENST00000382320.3_Missense_Mutation_p.H438Y|TTC6_ENST00000267368.7_Missense_Mutation_p.H358Y					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		TGGGGTGATTCATGAGTTTAT	0.363000													38	81					0	0	1	0	0
SYT7	9066	broad.mit.edu	37	11	61291963	61291963	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:61291963G>A	ENST00000263846.4	-	6	991	c.664C>T	c.(664-666)Caa>Taa	p.Q222*	SYT7_ENST00000535826.1_Nonsense_Mutation_p.Q341*|SYT7_ENST00000542836.1_Nonsense_Mutation_p.Q266*|SYT7_ENST00000539008.1_Nonsense_Mutation_p.Q505*|SYT7_ENST00000540677.1_Nonsense_Mutation_p.Q297*|SYT7_ENST00000540831.1_5'UTR|SYT7_ENST00000542670.1_Nonsense_Mutation_p.Q430*	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	222	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TCCAGGACTTGGAGGTAGAGG	0.587000													6	58					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51133180	51133180	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51133180C>T	ENST00000338916.4	-	3	1556	c.923G>A	c.(922-924)cGg>cAg	p.R308Q	SYT3_ENST00000544769.1_Missense_Mutation_p.R308Q|SYT3_ENST00000593901.1_Missense_Mutation_p.R308Q|SYT3_ENST00000600079.1_Missense_Mutation_p.R308Q	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	308	C2 1.					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity	p.R308Q(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		ATAGAGGTACCGCAGGGCGAA	0.672000													8	105					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219123	67219123	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67219123G>A	ENST00000312457.2	-	1	1077	c.1073C>T	c.(1072-1074)cCt>cTt	p.P358L		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	358						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GTTCACCTGAGGCTGGGCCAC	0.627000													22	38					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67380160	67380160	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67380160G>A	ENST00000329956.6	+	3	219	c.198_splice	c.e3-1	p.G67_splice	LRRC36_ENST00000563303.1_3'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	67										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TCCTTGTAGGGAATCCAGTAT	0.358000													24	74					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22134151	22134151	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22134151C>T	ENST00000408935.1	+	1	855	c.855C>T	c.(853-855)ttC>ttT	p.F285F		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TGAATCCCTTCATTTACACCT	0.453000													16	71					0	0	1	0	0
FKBP6	8468	broad.mit.edu	37	7	72742623	72742623	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72742623G>A	ENST00000252037.4	+	2	172	c.103G>A	c.(103-105)Gac>Aac	p.D35N	FKBP6_ENST00000431982.2_Missense_Mutation_p.D30N|FKBP6_ENST00000413573.2_Missense_Mutation_p.D35N	NM_003602.3	NP_003593.3	O75344	FKBP6_HUMAN	FK506 binding protein 6, 36kDa	35					protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	16		Lung NSC(55;0.0908)|all_lung(88;0.198)				CATCTCGGGGGACCGGGGCGT	0.632000													9	41					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43625187	43625187	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43625187G>A	ENST00000405006.4	-	29	4501	c.4150C>T	c.(4150-4152)Cga>Tga	p.R1384*	THADA_ENST00000405975.2_Nonsense_Mutation_p.R1384*|THADA_ENST00000330266.7_Intron|THADA_ENST00000485353.1_5'UTR|THADA_ENST00000415080.2_Nonsense_Mutation_p.R1065*	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1384							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AACAGAGTTCGAATGGTATTA	0.493000													50	73					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50111267	50111267	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:50111267C>T	ENST00000281631.5	+	15	1735	c.1575_splice	c.e15-1	p.P526_splice	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505697.2_Splice_Site_p.P526_splice|PARP8_ENST00000503750.2_Splice_Site_p.P526_splice|PARP8_ENST00000505554.1_Splice_Site_p.P505_splice|PARP8_ENST00000514067.2_Splice_Site_p.P526_splice|PARP8_ENST00000514342.2_Splice_Site_p.P279_splice	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	526						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				CTTTTGTAGCCTACCGTATGT	0.358000													14	59					0	0	1	0	0
OR2T34	127068	broad.mit.edu	37	1	248737532	248737532	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248737532G>A	ENST00000328782.2	-	1	548	c.527C>T	c.(526-528)tCt>tTt	p.S176F		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATTTTCCTAGACTGGCAAAA	0.527000													43	82					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9100123	9100123	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9100123C>T	ENST00000377424.4	-	6	876	c.697_splice	c.e6+1	p.A233_splice	SLC2A5_ENST00000535586.1_Splice_Site_p.A118_splice|SLC2A5_ENST00000536305.1_Splice_Site_p.A174_splice	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	233					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCCTCGTTACCTTTCTTGGCG	0.687000													8	26					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3342631	3342631	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3342631G>A	ENST00000378398.3	+	15	3208	c.3126G>A	c.(3124-3126)ggG>ggA	p.G1042G	PRDM16_ENST00000378391.2_Silent_p.G1042G|PRDM16_ENST00000270722.5_Silent_p.G1042G|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Silent_p.G1041G|PRDM16_ENST00000441472.2_Silent_p.G1041G|PRDM16_ENST00000514189.1_Silent_p.G1042G|PRDM16_ENST00000511072.1_Silent_p.G1043G			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	1042	Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGCACCCCGGGGTCCTCACGA	0.637000			T	EVI1	"""MDS, AML"""								17	29					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36714235	36714235	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36714235G>A	ENST00000244751.2	-	16	1762	c.1138C>T	c.(1138-1140)Cct>Tct	p.P380S	CPNE5_ENST00000393189.2_Missense_Mutation_p.P88S|CPNE5_ENST00000459703.1_5'UTR	NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	380	VWFA.									central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						CCCAGGGCAGGGAACATCTTG	0.627000													17	86					0	0	1	0	0
SOCS7	30837	broad.mit.edu	37	17	36521282	36521282	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:36521282C>T	ENST00000577233.1	+	4	1050	c.1050C>T	c.(1048-1050)ccC>ccT	p.P350P	SOCS7_ENST00000331159.5_Intron	NM_014598.2	NP_055413.1	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	350	Mediates interaction with SORBS3.|Poly-Pro.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			central_nervous_system(1)|endometrium(1)|kidney(1)|prostate(1)|skin(5)	9	Breast(7;3.47e-17)					CTCCTCCACCCCATGCCCCAG	0.493000													13	20					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124840115	124840115	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:124840115G>A	ENST00000356219.3	-	25	3420	c.3265C>T	c.(3265-3267)Cac>Tac	p.H1089Y	NCOR2_ENST00000404121.2_Missense_Mutation_p.H643Y|NCOR2_ENST00000405201.1_Missense_Mutation_p.H1082Y|NCOR2_ENST00000404621.1_Missense_Mutation_p.H1072Y|NCOR2_ENST00000429285.2_Missense_Mutation_p.H1072Y|NCOR2_ENST00000397355.1_Missense_Mutation_p.H1073Y	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1090					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGCAGTGGGTGACCTGTGGAG	0.677000													10	12					0	0	1	0	0
KRTAP5-9	3846	broad.mit.edu	37	11	71260054	71260054	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71260054C>T	ENST00000528743.2	+	1	589	c.351C>T	c.(349-351)tcC>tcT	p.S117S		NM_005553.3	NP_005544.4	P26371	KRA59_HUMAN	keratin associated protein 5-9	117	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament				kidney(1)|large_intestine(1)|lung(6)|prostate(3)	11						CCTGTTGCTCCTCCTCGGGTC	0.622000													61	168					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16168605	16168605	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:16168605C>T	ENST00000380289.2	+	2	989	c.591C>T	c.(589-591)gcC>gcT	p.A197A		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	197					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					TTAGCTGTGCCCCATACCCAC	0.488000													72	43					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150445091	150445091	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:150445091C>T	ENST00000401000.4	+	10	3654	c.3589C>T	c.(3589-3591)Cat>Tat	p.H1197Y	RPRD2_ENST00000369068.4_Missense_Mutation_p.H1223Y|RPRD2_ENST00000492220.1_3'UTR			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1223	Pro-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TCCTAAGGATCATGGTGGTAT	0.572000													36	101					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9052063	9052063	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:9052063G>A	ENST00000382496.5	-	20	3432	c.2767C>T	c.(2767-2769)Ctg>Ttg	p.L923L		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	923	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						ATGGGGAACAGGAGGATGCAC	0.587000													14	38					0	0	1	0	0
STK33	65975	broad.mit.edu	37	11	8478937	8478937	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:8478937C>T	ENST00000447869.1	-	5	1566	c.648G>A	c.(646-648)agG>agA	p.R216R	STK33_ENST00000358872.3_Silent_p.R29R|STK33_ENST00000534493.1_Silent_p.R175R|STK33_ENST00000315204.1_Silent_p.R216R|STK33_ENST00000396673.1_Silent_p.R216R|STK33_ENST00000396672.1_Silent_p.R216R			Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	216	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|skin(3)	23				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		GAATGATCCACCTTGTCTCAT	0.393000													23	66					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208270	58208270	+	Silent	SNP	G	G	A	rs151242806	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:58208270G>A	ENST00000377918.3	+	1	1616	c.1590G>A	c.(1588-1590)acG>acA	p.T530T		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	530	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGAATCCCACGAACGGGGCCA	0.587000													16	66					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21481174	21481174	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:21481174G>A	ENST00000313654.9	+	48	6329	c.6088G>A	c.(6088-6090)Gaa>Aaa	p.E2030K	LAMA3_ENST00000587184.1_Missense_Mutation_p.E365K|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000269217.6_Missense_Mutation_p.E421K|LAMA3_ENST00000399516.3_Missense_Mutation_p.E1974K	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2030	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCTTTAAATGAATACGAAGC	0.507000													23	49					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31606074	31606074	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:31606074C>T	ENST00000170150.3	+	8	782	c.587C>T	c.(586-588)cCc>cTc	p.P196L		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	196						extracellular region	lipid binding										GGCCTCAACCCCGTGGGTCCT	0.478000													18	73					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55572982	55572982	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55572982G>A	ENST00000294383.6	-	40	4691	c.4692C>T	c.(4690-4692)atC>atT	p.I1564I	USP24_ENST00000407756.1_Silent_p.I1404I	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1564					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CTGCCAGTAAGATGTTGTCCG	0.463000													11	66					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21789388	21789388	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21789388C>T	ENST00000328843.6	+	54	8818	c.8787C>T	c.(8785-8787)ttC>ttT	p.F2929F	DNAH11_ENST00000409508.3_Silent_p.F2922F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2929	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATGAGAGCTTCCTCGTGCTGA	0.438000									Kartagener syndrome				20	45					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469120	72469120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:72469120C>T	ENST00000296776.5	+	1	99	c.50C>T	c.(49-51)tCc>tTc	p.S17F	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	17						integral to membrane		p.S17F(1)		endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		AATGTGTTCTCCGTCACTCCT	0.577000													33	264					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150723772	150723772	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150723772C>T	ENST00000335244.4	-	2	350	c.221G>A	c.(220-222)gGa>gAa	p.G74E	SLC36A2_ENST00000521967.1_Missense_Mutation_p.G74E	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	74					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGGGGTAGTCCCAGGATCCC	0.552000													6	58					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15989593	15989593	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15989593C>T	ENST00000221700.5	-	13	1646	c.1551G>A	c.(1549-1551)gaG>gaA	p.E517E	CYP4F2_ENST00000592328.1_Silent_p.E517E	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	517					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AGCTCAGGGGCTCCACCCGCA	0.607000													15	33					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207297708	207297708	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207297708G>A	ENST00000367070.3	+	6	897	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	235	Sushi 3.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						TCCTACCTGTGAAAGTAAGTC	0.418000													15	51					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39821156	39821156	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:39821156G>A	ENST00000502986.2	+	3	410	c.168G>A	c.(166-168)tgG>tgA	p.W56*	RP11-44K6.3_ENST00000517623.1_RNA|IDO2_ENST00000389060.4_Nonsense_Mutation_p.W43*|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	43					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						ATAGGCCTTGGATGGAAATTG	0.398000													6	16					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84474551	84474551	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:84474551G>A	ENST00000416219.2	+	14	1387	c.1298G>A	c.(1297-1299)gGa>gAa	p.G433E	ATP2C2_ENST00000420010.2_3'UTR|ATP2C2_ENST00000262429.4_Missense_Mutation_p.G433E			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	433					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						GTCTCAGTGGGAAAGTTAGTG	0.493000													7	16					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78799654	78799654	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:78799654G>A	ENST00000545128.1	+	17	2801	c.2263G>A	c.(2263-2265)Gaa>Aaa	p.E755K	PCSK5_ENST00000376752.4_Missense_Mutation_p.E755K	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	755	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TAACTGTACAGAATGTAGGGA	0.338000													22	23					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17012086	17012086	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17012086G>A	ENST00000443236.1	-	36	4879	c.4848C>T	c.(4846-4848)tcC>tcT	p.S1616S		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1569						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CAGCCATATTGGAAGACCCTG	0.637000													4	21					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837712	82837712	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82837712G>A	ENST00000265077.3	+	8	9455	c.8890G>A	c.(8890-8892)Gat>Aat	p.D2964N	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.D1977N|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2964	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TACAACTGCCGATGAAATTGA	0.463000													61	147					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27529141	27529141	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27529141G>A	ENST00000296098.4	+	8	1323	c.1053G>A	c.(1051-1053)atG>atA	p.M351I	TRIM54_ENST00000380075.2_Missense_Mutation_p.M309I	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	309					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGAGAGCATGGAGCAATTCA	0.652000													17	51					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44449852	44449852	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:44449852C>T	ENST00000360029.3	-	1	972	c.689G>A	c.(688-690)cGg>cAg	p.R230Q		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	230						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CGCCACACGCCGGAATTTGGC	0.721000										HNSCC(17;0.042)			5	10					0	0	1	0	0
OR8I2	120586	broad.mit.edu	37	11	55861330	55861330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55861330C>T	ENST00000302124.2	+	1	578	c.547C>T	c.(547-549)Ctt>Ttt	p.L183F	OR8I2_ENST00000560768.1_Missense_Mutation_p.L183F			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L183F(1)		NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					CACCACAGCTCTTTTAGCACT	0.438000													51	165					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36091374	36091374	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:36091374G>A	ENST00000378660.1	+	4	497	c.309G>A	c.(307-309)aaG>aaA	p.K103K	CHDC2_ENST00000313548.4_Silent_p.K103K					calponin homology domain containing 2																		AAGGAACAAAGGCACACTACT	0.408000													51	50					0	0	1	0	0
C15orf26	161502	broad.mit.edu	37	15	81427637	81427637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81427637G>A	ENST00000286732.4	+	2	179	c.96G>A	c.(94-96)aaG>aaA	p.K32K		NM_173528.2	NP_775799.2	Q6P656	CO026_HUMAN	chromosome 15 open reading frame 26	32										endometrium(1)|kidney(4)|large_intestine(5)|lung(6)|skin(1)	17						TCTTAGAGAAGAGAGACAAGG	0.323000													18	113					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	77006657	77006657	+	Silent	SNP	G	G	A	rs138204887	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:77006657G>A	ENST00000257626.7	-	9	705	c.627C>T	c.(625-627)ttC>ttT	p.F209F		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		GAGCCCAAACGAAATCCTCAG	0.303000													31	244					0	0	1	0	0
POLR2E	5434	broad.mit.edu	37	19	1090119	1090119	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:1090119G>A	ENST00000215587.7	-	5	738	c.455C>T	c.(454-456)aCc>aTc	p.T152I	POLR2E_ENST00000585838.1_5'UTR|POLR2E_ENST00000586746.1_Missense_Mutation_p.T152I			P19388	RPAB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	152					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|skin(2)	11		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCTCCTTGGTCATGACGAC	0.662000													11	35					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142605896	142605896	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142605896A>C	ENST00000265310.1	-	15	2322	c.1974T>G	c.(1972-1974)gaT>gaG	p.D658E		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	658					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCTCCTGGTCATCCTCCTTGT	0.537000													13	59					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111164350	111164350	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:111164350C>T	ENST00000360467.5	+	48	5257	c.4951C>T	c.(4951-4953)Cgc>Tgc	p.R1651C		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1651	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGAGGACTTCCGCGCCACACC	0.617000													33	69					0	0	1	0	0
THEM5	284486	broad.mit.edu	37	1	151820663	151820663	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151820663G>A	ENST00000368817.5	-	4	701	c.570C>T	c.(568-570)ttC>ttT	p.F190F	AL450992.2_ENST00000434182.1_RNA	NM_182578.3	NP_872384.1	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	190							hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTTACTTTTTGAACCTGATGT	0.562000													37	106					0	0	1	0	0
HSF5	124535	broad.mit.edu	37	17	56565478	56565478	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56565478G>A	ENST00000323777.3	-	1	267	c.158C>T	c.(157-159)cCg>cTg	p.P53L		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	53						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					cggcccgggcgggcTGAGCAG	0.721000													5	12					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30024934	30024934	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:30024934G>A	ENST00000346128.6	-	14	2296	c.1822C>T	c.(1822-1824)Cgc>Tgc	p.R608C	TJP1_ENST00000356107.6_Missense_Mutation_p.R608C|TJP1_ENST00000400011.2_Missense_Mutation_p.R612C|TJP1_ENST00000545208.2_Missense_Mutation_p.R608C	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	608	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TTGGAGCTGCGAAGACCTCTG	0.473000													16	65					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5011051	5011051	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5011051C>T	ENST00000380390.1	+	3	489	c.273C>T	c.(271-273)tcC>tcT	p.S91S	MMP26_ENST00000300762.1_Silent_p.S91S|MMP26_ENST00000477339.1_3'UTR			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	91					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCGACACCTCCATCTCGCCAG	0.517000													20	50					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	101013182	101013182	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:101013182G>A	ENST00000284382.4	-	10	1108	c.685C>T	c.(685-687)Cgc>Tgc	p.R229C	CERS3_ENST00000394113.1_Missense_Mutation_p.R229C|CERS3_ENST00000538112.2_Missense_Mutation_p.R229C|CERS3_ENST00000560944.1_Intron	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	229	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GTCCCACTGCGAATATAATTA	0.438000													15	156					0	0	1	0	0
TXNRD2	10587	broad.mit.edu	37	22	19865928	19865928	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:19865928G>A	ENST00000400519.1	-	15	1304	c.1305C>T	c.(1303-1305)ttC>ttT	p.F435F	TXNRD2_ENST00000542719.1_Silent_p.F406F|TXNRD2_ENST00000400521.1_Silent_p.F436F|TXNRD2_ENST00000400525.1_Silent_p.F413F|TXNRD2_ENST00000400518.1_Silent_p.F406F|TXNRD2_ENST00000535882.1_Silent_p.F435F			Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2	436					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|urinary_tract(2)	30	Colorectal(54;0.0993)					CAGCCACCGTGAACTCCAGTG	0.562000													78	170					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31332892	31332892	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31332892G>A	ENST00000544665.3	+	16	2020	c.1949G>A	c.(1948-1950)gGa>gAa	p.G650E	ITGAM_ENST00000287497.8_Missense_Mutation_p.G649E	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	649					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						AAGGAAGCCGGAGAGGTCAGA	0.512000													51	122					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62070963	62070963	+	Silent	SNP	G	G	A	rs118192212		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62070963G>A	ENST00000354587.3	-	6	1091	c.915C>T	c.(913-915)ttC>ttT	p.F305F	KCNQ2_ENST00000370221.1_Silent_p.F305F|KCNQ2_ENST00000359125.2_Silent_p.F305F|KCNQ2_ENST00000360480.3_Silent_p.F305F|KCNQ2_ENST00000430658.1_Silent_p.F305F|KCNQ2_ENST00000344462.3_Silent_p.F305F|KCNQ2_ENST00000359689.1_Silent_p.F305F|KCNQ2_ENST00000370224.1_Silent_p.F305F|KCNQ2_ENST00000357249.2_Silent_p.F305F|KCNQ2_ENST00000370226.1_Silent_p.F305F|KCNQ2_ENST00000370222.3_Silent_p.F305F|KCNQ2_ENST00000344425.5_Silent_p.F305F			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	305					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CAGGCAGCGCGAAGAAGGAGA	0.632000													26	96					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83770408	83770408	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:83770408C>T	ENST00000398309.2	-	6	1024	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000524982.1_Missense_Mutation_p.R185Q|DLG2_ENST00000532653.1_Missense_Mutation_p.R185Q|DLG2_ENST00000398301.2_Missense_Mutation_p.R224Q|DLG2_ENST00000330014.6_Missense_Mutation_p.R124Q|DLG2_ENST00000543673.1_Missense_Mutation_p.R290Q|DLG2_ENST00000376104.2_Missense_Mutation_p.R290Q|DLG2_ENST00000280241.8_Missense_Mutation_p.R224Q|DLG2_ENST00000531015.1_Missense_Mutation_p.R152Q|DLG2_ENST00000537455.1_5'UTR|DLG2_ENST00000418306.2_Missense_Mutation_p.R134Q	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	185						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CAAAATAGGTCGTCTTCTACG	0.458000													28	116					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15107640	15107640	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15107640C>T	ENST00000378217.3	+	7	806	c.619C>T	c.(619-621)Cat>Tat	p.H207Y	OLAH_ENST00000485251.1_3'UTR|OLAH_ENST00000378228.3_Missense_Mutation_p.H154Y	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	154					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						ACAAATAAGTCATTACCTTAT	0.403000													15	51					0	0	1	0	0
MORN1	79906	broad.mit.edu	37	1	2288982	2288982	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:2288982G>A	ENST00000378531.3	-	10	1098	c.925C>T	c.(925-927)Ccc>Tcc	p.P309S	MORN1_ENST00000378529.3_Missense_Mutation_p.P309S|MORN1_ENST00000606372.1_5'UTR	NM_024848.1	NP_079124.1	Q5T089	MORN1_HUMAN	MORN repeat containing 1	309										breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(1)|ovary(2)	9	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		GCAGCTCTGGGCCCCGGCACC	0.657000													37	101					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51192483	51192483	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51192483C>T	ENST00000293441.1	-	15	2036	c.2018G>A	c.(2017-2019)gGg>gAg	p.G673E	SHANK1_ENST00000391813.1_Missense_Mutation_p.G60E|SHANK1_ENST00000359082.3_Missense_Mutation_p.G664E|SHANK1_ENST00000391814.1_Missense_Mutation_p.G673E	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	673	PDZ.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GAACCCAAACCCCTCACTGTC	0.612000													18	151					0	0	1	0	0
ENAH	55740	broad.mit.edu	37	1	225702509	225702509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:225702509G>A	ENST00000366844.2	-	7	1458	c.1007C>T	c.(1006-1008)cCc>cTc	p.P336L	ENAH_ENST00000284563.6_Missense_Mutation_p.P583L|ENAH_ENST00000366843.2_Missense_Mutation_p.P336L	NM_001008493.1	NP_001008493.1	Q8N8S7	ENAH_HUMAN	enabled homolog (Drosophila)	336	Pro-rich.				axon guidance|intracellular transport|T cell receptor signaling pathway	cytosol|filopodium|focal adhesion|lamellipodium|synapse	actin binding|SH3 domain binding|WW domain binding			NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.19)		aggtggagggggccctggggg	0.672000													7	14					0	0	1	0	0
ZNF788	388507	broad.mit.edu	37	19	12223856	12223856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12223856G>A	ENST00000339302.4	+	3	2131	c.1494G>A	c.(1492-1494)ggG>ggA	p.G498G	ZNF20_ENST00000600335.1_Intron|ZNF788_ENST00000397759.3_Silent_p.G117G|ZNF788_ENST00000430298.2_3'UTR					zinc finger family member 788											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	2						CTCACATTGGGGAGAAACCCT	0.418000													5	34					0	0	1	0	0
CXCL11	6373	broad.mit.edu	37	4	76956249	76956249	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:76956249C>T	ENST00000306621.3	-	3	421	c.212G>A	c.(211-213)gGa>gAa	p.G71E	ART3_ENST00000341029.5_Intron|CXCL11_ENST00000503860.1_Missense_Mutation_p.G71E	NM_005409.4	NP_005400.1	O14625	CXL11_HUMAN	chemokine (C-X-C motif) ligand 11	71				NKGQ -> IRK (in Ref. 1; AAB17374).	cell-cell signaling|chemotaxis|inflammatory response|signal transduction	extracellular space	chemokine activity			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCATCGTTGTCCTTTATTTTC	0.328000													34	89					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768049	57768049	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57768049C>T	ENST00000371030.2	+	1	1975	c.1975C>T	c.(1975-1977)Cct>Tct	p.P659S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	659						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					ACTGGGCTTTCCTCTGCAGAA	0.582000													20	62					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234769	21234769	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21234769C>T	ENST00000233242.1	-	26	5098	c.4971G>A	c.(4969-4971)acG>acA	p.T1657T		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1657					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAAGTTGGTCGTTGCACTGG	0.453000													16	56					0	0	1	0	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20170315	20170315	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:20170315C>T	ENST00000338912.5	-	0	39																											CTACCTGCAGCTATGACCACC	0.542000													35	122					0	0	1	0	0
PRPSAP1	5635	broad.mit.edu	37	17	74328431	74328431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74328431G>A	ENST00000446526.3	-	4	821	c.376C>T	c.(376-378)Ccc>Tcc	p.P126S	PRPSAP1_ENST00000324684.4_Missense_Mutation_p.P23S	NM_002766.2	NP_002757.2	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 1	97					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17						GGGAAGTAGGGGATGACCCCA	0.517000													44	108					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53544406	53544406	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53544406G>A	ENST00000371500.3	+	10	1652	c.1311G>A	c.(1309-1311)gaG>gaA	p.E437E	PODN_ENST00000395871.2_Silent_p.E314E|RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000312553.5_Silent_p.E456E	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	408					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TCCTGGAGGAGCTCAACCTCA	0.657000													49	118					0	0	1	0	0
PLVAP	83483	broad.mit.edu	37	19	17476457	17476457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17476457C>T	ENST00000252590.4	-	3	878	c.817G>A	c.(817-819)Gac>Aac	p.D273N		NM_031310.1	NP_112600.1	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	273						caveola|integral to membrane|perinuclear region of cytoplasm				cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GGCATGTGGTCGCAGGCTCTG	0.637000													14	59					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606842	55606842	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55606842C>T	ENST00000378396.1	+	1	615	c.615C>T	c.(613-615)gcC>gcT	p.A205A		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TCACTGTTGCCACTTTTAATG	0.423000													30	99					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95603935	95603935	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:95603935C>T	ENST00000343958.4	-	2	1348	c.1125G>A	c.(1123-1125)gtG>gtA	p.V375V	FGD6_ENST00000549499.1_Silent_p.V375V|FGD6_ENST00000546711.1_Silent_p.V375V	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	375					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						TCATTTTATCCACCTGTTCCT	0.353000													27	70					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29997796	29997796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:29997796C>T	ENST00000308893.4	+	16	3246	c.2203C>T	c.(2203-2205)Cag>Tag	p.Q735*	TAOK2_ENST00000543033.1_Nonsense_Mutation_p.Q735*|TAOK2_ENST00000416441.2_Nonsense_Mutation_p.Q562*|TAOK2_ENST00000279394.3_Nonsense_Mutation_p.Q735*	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	735					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GCATGCGGCCCAGGTTCGCCA	0.672000													39	127					0	0	1	0	0
CPZ	8532	broad.mit.edu	37	4	8621299	8621299	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:8621299C>T	ENST00000429646.2	+	9	3531	c.738C>T	c.(736-738)ttC>ttT	p.F246F	CPZ_ENST00000360986.4_Silent_p.F638F|CPZ_ENST00000382480.2_Silent_p.F501F|CPZ_ENST00000315782.6_Silent_p.F627F			Q66K79	CBPZ_HUMAN	carboxypeptidase Z	638					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GGTCCTACTTCACATCGCTGA	0.701000													9	33					0	0	1	0	0
RPL5	6125	broad.mit.edu	37	1	93301949	93301949	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:93301949G>A	ENST00000370321.3	+	5	617	c.527_splice	c.e5+1	p.S176_splice		NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5	176				S -> R (in Ref. 9).	endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		ATCCCTCACAGGTAAGAATAC	0.453000													21	54					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3422738	3422738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3422738G>A	ENST00000356575.4	-	15	2078	c.1852C>T	c.(1852-1854)Cgg>Tgg	p.R618W	MEGF6_ENST00000294599.4_Missense_Mutation_p.R513W	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	618	EGF-like 11.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CGGTGGCACCGGCCCCGGTTG	0.652000													5	10					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63179424	63179424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:63179424G>A	ENST00000394968.1	-	11	2023	c.1856C>T	c.(1855-1857)tCc>tTc	p.S619F	KCNH5_ENST00000420622.2_Intron|KCNH5_ENST00000322893.7_Intron	NM_172376.1	NP_758964.1	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	0					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GTTTGCCATGGAGAACCATCC	0.502000													7	12					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153149867	153149867	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153149867C>T	ENST00000285900.5	+	13	2505	c.2162C>T	c.(2161-2163)aCc>aTc	p.T721I	GRIA1_ENST00000518783.1_Missense_Mutation_p.T731I|GRIA1_ENST00000521843.2_Missense_Mutation_p.T652I|GRIA1_ENST00000340592.5_Missense_Mutation_p.T721I|GRIA1_ENST00000448073.4_Missense_Mutation_p.T731I|GRIA1_ENST00000518142.1_Missense_Mutation_p.T641I	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	721					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTGGAGTCCACCATGAATGAG	0.502000													15	47					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160016608	160016608	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:160016608C>T	ENST00000327245.5	-	24	4587	c.3741G>A	c.(3739-3741)atG>atA	p.M1247I		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1247					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCATGTCTTCATTTCCATTG	0.443000													7	52					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304075	10304075	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10304075C>T	ENST00000403437.2	-	27	3461	c.3367G>A	c.(3367-3369)Gaa>Aaa	p.E1123K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1123					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCGATTTCTTCCCCCAGCTCC	0.522000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				34	29					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154395724	154395724	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:154395724G>A	ENST00000435029.4	+	1	2465	c.2305G>A	c.(2305-2307)Gaa>Aaa	p.E769K		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	769	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TGACCTCCTTGAAGACAGAAA	0.453000													19	44					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8500768	8500768	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:8500768C>T	ENST00000381196.4	-	21	2657	c.2114G>A	c.(2113-2115)cGa>cAa	p.R705Q	PTPRD_ENST00000358503.5_Missense_Mutation_p.R692Q|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.R705Q|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.R705Q|PTPRD_ENST00000360074.4_Missense_Mutation_p.R692Q|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000355233.5_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	705	Fibronectin type-III 4.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTCATTGGTTCGAATCAACAC	0.473000										TSP Lung(15;0.13)			41	64					0	0	1	0	0
IPCEF1	26034	broad.mit.edu	37	6	154533920	154533920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:154533920G>A	ENST00000265198.4	-	9	673	c.518C>T	c.(517-519)tCc>tTc	p.S173F	IPCEF1_ENST00000367220.4_Missense_Mutation_p.S174F|IPCEF1_ENST00000519344.1_Missense_Mutation_p.S145F|IPCEF1_ENST00000519091.1_5'UTR|OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000422970.2_Missense_Mutation_p.S174F	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						CTGAGTCTGGGAAGCGTGAGG	0.413000													15	28					0	0	1	0	0
MKNK1	8569	broad.mit.edu	37	1	47024335	47024335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47024335G>A	ENST00000371946.4	-	14	1473	c.1310C>T	c.(1309-1311)tCc>tTc	p.S437F	MKNK1_ENST00000341183.5_3'UTR|MKNK1-AS1_ENST00000602433.1_RNA|MKNK1_ENST00000371944.4_Missense_Mutation_p.S301F|MKNK1_ENST00000371945.4_Missense_Mutation_p.S396F	NM_003684.5	NP_003675.2	Q9BUB5	MKNK1_HUMAN	MAP kinase interacting serine/threonine kinase 1	437					intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	13	Acute lymphoblastic leukemia(166;0.155)					GCAGGGAGGGGAAAGCTTCAT	0.627000													22	36					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130492962	130492962	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130492962G>A	ENST00000373289.3	+	14	1980	c.1900G>A	c.(1900-1902)Gaa>Aaa	p.E634K	TTC16_ENST00000489226.1_3'UTR	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	634							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						TATCTGCCAGGAATACAGGAG	0.587000													7	37					0	0	1	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332737	71332737	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:71332737G>A	ENST00000242462.4	-	2	92	c.63C>T	c.(61-63)ttC>ttT	p.F21F		NM_020999.3	NP_066279.2	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	21					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity			endometrium(4)|large_intestine(2)|lung(6)|prostate(1)	13						AGGCTCTGGGGAAGGACCGCT	0.677000													22	62					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22941084	22941084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:22941084C>T	ENST00000397104.3	-	5	1353	c.1354G>A	c.(1354-1356)Ggc>Agc	p.G452S	ZNF99_ENST00000596209.1_Missense_Mutation_p.G543S					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAAGCTTTGCCACATTCTTCA	0.343000													17	72					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111470890	111470890	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111470890G>A	ENST00000265162.5	+	17	2691	c.2349G>A	c.(2347-2349)agG>agA	p.R783R		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	783					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TAAATCTCAGGCTTCTGGTGT	0.388000													18	104					0	0	1	0	0
CCR1	1230	broad.mit.edu	37	3	46245220	46245220	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46245220C>T	ENST00000296140.3	-	2	710	c.585G>A	c.(583-585)tgG>tgA	p.W195*	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	195					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GAAACAGCTTCCACTCTCGTA	0.468000													36	73					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9389741	9389741	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:9389741G>A	ENST00000378501.2	+	20	1891	c.1876G>A	c.(1876-1878)Gga>Aga	p.G626R	PLCB4_ENST00000414679.2_Missense_Mutation_p.G638R|PLCB4_ENST00000378493.1_Missense_Mutation_p.G626R|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.G626R|PLCB4_ENST00000378473.3_Missense_Mutation_p.G638R|PLCB4_ENST00000334005.3_Missense_Mutation_p.G626R	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	626	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TTACCCCAAGGGAGGCCGAGT	0.423000													11	31					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530609	140530609	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140530609C>T	ENST00000231136.1	+	1	771	c.771C>T	c.(769-771)ggC>ggT	p.G257G	PCDHB6_ENST00000543635.1_Silent_p.G121G	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		257	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCCCCTCGGCTCTCTGGTTA	0.507000													15	43					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111154975	111154975	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111154975C>T	ENST00000280325.4	+	3	329	c.182C>T	c.(181-183)cCc>cTc	p.P61L		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	61										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CCCTACTTCCCCCAGGAGCCC	0.667000													44	86					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174673	207174673	+	Silent	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207174673C>A	ENST00000374423.3	+	5	5807	c.5421C>A	c.(5419-5421)gtC>gtA	p.V1807V		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1807							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CAAAGGATGTCATAGAGGATA	0.408000													29	48					3.57733e-08	3.5889e-08	1	1	0
CEACAM16	388551	broad.mit.edu	37	19	45209064	45209064	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45209064G>A	ENST00000587331.1	+	5	1081	c.866G>A	c.(865-867)gGg>gAg	p.G289E	CEACAM16_ENST00000405314.2_Missense_Mutation_p.G289E|CTB-171A8.1_ENST00000590796.1_RNA	NM_001039213.2	NP_001034302.2	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 16	289										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				GCCCAGGAGGGGACGTACACA	0.587000													47	82					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7242285	7242285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7242285G>A	ENST00000542285.1	-	4	615	c.466C>T	c.(466-468)Ccc>Tcc	p.P156S				P00736	C1R_HUMAN	complement component 1, r subcomponent	157	EGF-like; calcium-binding (Potential).				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGGGGCTGGGGATCCTCCTCC	0.562000													23	40					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8212211	8212211	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8212211C>T	ENST00000600128.1	-	2	568	c.154G>A	c.(154-156)Ggc>Agc	p.G52S	FBN3_ENST00000601739.1_Missense_Mutation_p.G52S|FBN3_ENST00000270509.2_Missense_Mutation_p.G52S			Q75N90	FBN3_HUMAN	fibrillin 3	52						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGCAAGATGCCTGGGCTGCCC	0.692000													4	10					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122551357	122551357	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:122551357G>A	ENST00000264357.5	+	11	1897	c.1605G>A	c.(1603-1605)aaG>aaA	p.K535K	GRIA3_ENST00000542149.1_Silent_p.K535K|GRIA3_ENST00000541091.1_Silent_p.K519K|GRIA3_ENST00000371256.5_Silent_p.K535K|GRIA3_ENST00000371251.1_Silent_p.K535K	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	535					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TCATGATAAAGAAGCCTCAGA	0.428000													87	63					0	0	1	0	0
GPR31	2853	broad.mit.edu	37	6	167570885	167570885	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:167570885G>A	ENST00000366834.1	-	1	932	c.435C>T	c.(433-435)ctC>ctT	p.L145L		NM_005299.2	NP_005290.2	O00270	GPR31_HUMAN	G protein-coupled receptor 31	145						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(4)|large_intestine(4)|lung(7)|prostate(1)	17		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		CCGGGCAGGTGAGGGCGACCA	0.647000													25	42					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113920566	113920566	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:113920566G>A	ENST00000348367.4	-	16	1752	c.1555C>T	c.(1555-1557)Cgt>Tgt	p.R519C	GPAM_ENST00000369425.1_Missense_Mutation_p.R519C|GPAM_ENST00000423155.1_Missense_Mutation_p.R519C			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	519					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TCAAAATCACGAGCCAGGACT	0.443000													8	37					0	0	1	0	0
GABRA6	2559	broad.mit.edu	37	5	161119180	161119180	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:161119180G>A	ENST00000523217.1	+	8	1272	c.1030G>A	c.(1030-1032)Gaa>Aaa	p.E344K	GABRA6_ENST00000274545.5_Missense_Mutation_p.E354K	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	354					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAAAGCTACTGAACCTTTGGA	0.413000										TCGA Ovarian(5;0.080)			29	94					0	0	1	0	0
TRABD2A	129293	broad.mit.edu	37	2	85097546	85097546	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:85097546C>T	ENST00000335459.5	-	2	677	c.472G>A	c.(472-474)Gga>Aga	p.G158R	TRABD2A_ENST00000409133.1_Missense_Mutation_p.G158R|TRABD2A_ENST00000409520.2_Missense_Mutation_p.G158R	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		TCCCAGTTTCCGGCAATAGCA	0.562000													26	98					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75112979	75112979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75112979C>T	ENST00000309664.5	+	8	917	c.778C>T	c.(778-780)Ccc>Tcc	p.P260S	LMAN1L_ENST00000379709.3_Missense_Mutation_p.P248S	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	260						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCCCTAGGTTCCCCCTCAGCC	0.642000													40	183					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36982421	36982421	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:36982421G>A	ENST00000274963.8	+	7	994		c.e7-1			NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2						actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						GCCCCTTTCAGAAGCCCTGGA	0.597000													16	38					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127668645	127668645	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127668645C>T	ENST00000508053.1	-	38	5155	c.4181G>A	c.(4180-4182)aGc>aAc	p.S1394N	FBN2_ENST00000262464.4_Missense_Mutation_p.S1394N|FBN2_ENST00000508989.1_Missense_Mutation_p.S1361N|FBN2_ENST00000507835.1_Missense_Mutation_p.S244N			P35556	FBN2_HUMAN	fibrillin 2	1394	EGF-like 22; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTCTCTGCAGCTACACTTGAA	0.398000													50	192					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111861250	111861250	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111861250G>A	ENST00000369740.1	+	9	968	c.865G>A	c.(865-867)Ggt>Agt	p.G289S	RP5-1125M8.2_ENST00000426321.1_RNA|CHIA_ENST00000353665.6_Missense_Mutation_p.G128S|CHIA_ENST00000343320.6_Missense_Mutation_p.G289S|CHIA_ENST00000483391.1_Missense_Mutation_p.G128S|CHIA_ENST00000451398.2_Missense_Mutation_p.G128S|CHIA_ENST00000430615.1_Missense_Mutation_p.G181S	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	289					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		CTCTGGTGCTGGTCCTGCTGG	0.537000													60	103					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113565931	113565931	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113565931C>T	ENST00000546530.1	-	4	460	c.175G>A	c.(175-177)Gtg>Atg	p.V59M	RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000261729.5_Missense_Mutation_p.V59M|RASAL1_ENST00000446861.3_Missense_Mutation_p.V59M|RASAL1_ENST00000548055.1_Missense_Mutation_p.V59M	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	59	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						GGCAGGTGCACCGTGTACTCC	0.617000													90	228					0	0	1	0	0
OR1J4	26219	broad.mit.edu	37	9	125282298	125282298	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125282298G>A	ENST00000340750.1	+	1	879	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						ATAGCCTAAGGAACAGGGACA	0.458000													23	52					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105169497	105169497	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105169497C>T	ENST00000392634.4	+	3	559	c.447C>T	c.(445-447)gcC>gcT	p.A149A	INF2_ENST00000398337.4_Silent_p.A149A|INF2_ENST00000330634.7_Silent_p.A149A	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	149	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TACTGGCTGCCCTGTGCATCT	0.652000													14	40					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431856	140431856	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140431856G>A	ENST00000306549.3	+	1	878	c.801G>A	c.(799-801)gtG>gtA	p.V267V		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		267	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGACTGCCGTGGACCTAGACG	0.517000													9	38					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55210706	55210706	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:55210706C>T	ENST00000396834.1	+	16	2207	c.1711C>T	c.(1711-1713)Ccc>Tcc	p.P571S	IL31RA_ENST00000354961.4_Missense_Mutation_p.P571S|IL31RA_ENST00000447346.2_Missense_Mutation_p.P590S|IL31RA_ENST00000359040.5_Missense_Mutation_p.P590S|IL31RA_ENST00000490985.1_Missense_Mutation_p.P448S	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	558					anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GCCCACCGTTCCCAACCCTGC	0.428000													22	98					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61510285	61510285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:61510285G>A	ENST00000398571.2	-	37	5069	c.4993C>T	c.(4993-4995)Cct>Tct	p.P1665S		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	1665					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			CTTACCTCAGGAATAAGGAGA	0.343000													25	69					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145393331	145393331	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:145393331C>T	ENST00000511217.1	+	4	818	c.766C>T	c.(766-768)Ctt>Ttt	p.L256F	SH3RF2_ENST00000359120.4_Missense_Mutation_p.L256F			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	256							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGCAAGACACCTTTTAGAGAA	0.507000													11	89					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143098600	143098600	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143098600G>A	ENST00000275815.3	-	3	335	c.249C>T	c.(247-249)tcC>tcT	p.S83S		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	83						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				AGATCCAATTGGAGCGAAGCC	0.602000													61	219					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40945418	40945418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:40945418C>T	ENST00000313164.9	+	7	1045	c.686C>T	c.(685-687)tCa>tTa	p.S229L		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	229	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				AGATCTTCATCATCTTCTTCA	0.313000													10	25					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003723	122003723	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:122003723C>T	ENST00000498619.1	+	7	3390	c.2952C>T	c.(2950-2952)acC>acT	p.T984T	CASR_ENST00000296154.5_Silent_p.T974T|CASR_ENST00000490131.1_Silent_p.T974T	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	974					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCACGGTCACCTTCTCACTGA	0.577000													15	45					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72036313	72036313	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:72036313G>A	ENST00000378743.3	-	6	1888	c.1530C>T	c.(1528-1530)tcC>tcT	p.S510S		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	510					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GCTTATCTAAGGATCGCCTCA	0.373000													42	146					0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18763838	18763838	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:18763838G>A	ENST00000396170.1	-	7	1864	c.600C>T	c.(598-600)ctC>ctT	p.L200L	PTPN5_ENST00000477854.1_Silent_p.L36L|PTPN5_ENST00000358540.2_Silent_p.L232L|PTPN5_ENST00000396171.4_Silent_p.L232L|PTPN5_ENST00000496201.2_5'UTR|PTPN5_ENST00000396167.2_Silent_p.L200L|PTPN5_ENST00000396168.1_Silent_p.L208L	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	232						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						ACTTGACGGTGAGTGAGGTGG	0.592000													44	104					0	0	1	0	0
PILRB	29990	broad.mit.edu	37	7	99956641	99956641	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99956641C>T	ENST00000444874.1	+	15	2084	c.184C>T	c.(184-186)Ccg>Tcg	p.P62S	PILRB_ENST00000452089.1_Silent_p.T131T|PILRB_ENST00000448382.1_Missense_Mutation_p.P184S|PILRB_ENST00000310771.4_Silent_p.T131T|PILRB_ENST00000444073.1_Silent_p.T131T			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	0	Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGCTGGACACCCGGAGATCAG	0.592000													39	70					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567206	45567206	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:45567206G>A	ENST00000588982.1	-	3	774	c.273C>T	c.(271-273)ttC>ttT	p.F91F	ZBTB7C_ENST00000586438.1_Silent_p.F91F|ZBTB7C_ENST00000535628.2_Silent_p.F91F|ZBTB7C_ENST00000590800.1_Silent_p.F91F|ZBTB7C_ENST00000332053.2_Silent_p.F91F			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	91	BTB.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						AGGTGTAGGCGAACTCCAGGA	0.572000													22	49					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96781867	96781867	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:96781867G>T	ENST00000359933.4	-	22	4308	c.3415C>A	c.(3415-3417)Cgc>Agc	p.R1139S		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1139										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CAGTGTGGGCGGGTTGAGCTG	0.428000													8	43					3.09899e-07	3.10719e-07	1	1	0
MYL1	4632	broad.mit.edu	37	2	211163245	211163245	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211163245G>A	ENST00000352451.3	-	3	350	c.203C>T	c.(202-204)tCc>tTc	p.S68F	MYL1_ENST00000341685.4_Missense_Mutation_p.S24F|MYL1_ENST00000496436.1_5'UTR	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	68	EF-hand 1.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GGTGATCTTGGAATCACCTGT	0.448000													35	59					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56922570	56922570	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:56922570G>A	ENST00000520220.2	+	13	1651	c.1377G>A	c.(1375-1377)tgG>tgA	p.W459*	LYN_ENST00000519728.1_Nonsense_Mutation_p.W480*	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	480	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			AAATGTGCTGGAAAGAAAAGG	0.512000													11	86					0	0	1	0	0
KLF17	128209	broad.mit.edu	37	1	44596233	44596233	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44596233C>T	ENST00000372299.3	+	3	1033	c.975C>T	c.(973-975)ttC>ttT	p.F325F	KLF17_ENST00000476802.1_3'UTR	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	325					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					GGTCTTTCTTCCGTTCTGATG	0.463000													38	85					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79165002	79165002	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:79165002G>A	ENST00000269392.4	-	22	3012	c.2765C>T	c.(2764-2766)gCc>gTc	p.A922V	AZI1_ENST00000374782.3_Missense_Mutation_p.A883V|AZI1_ENST00000450824.2_Missense_Mutation_p.A919V|AZI1_ENST00000575907.1_Missense_Mutation_p.A886V	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	922					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCGGCTCTCGGCAGCCTTCTC	0.647000													36	77					0	0	1	0	0
MRPS24	64951	broad.mit.edu	37	7	43906397	43906397	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:43906397G>A	ENST00000317534.5	-	4	466	c.405C>T	c.(403-405)ctC>ctT	p.L135L	RP5-1165K10.1_ENST00000603700.1_3'UTR	NM_032014.2	NP_114403.1	Q96EL2	RT24_HUMAN	mitochondrial ribosomal protein S24	135					translation	mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	5						TGTAGCCCACGAGGAAGTAGT	0.512000													35	67					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113298936	113298936	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:113298936G>A	ENST00000458497.1	+	3	282	c.3G>A	c.(1-3)atG>atA	p.M1I	ALPK1_ENST00000177648.9_Start_Codon_SNP_p.M1I|ALPK1_ENST00000504176.2_5'UTR	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TAATCATCATGAATAATCAAA	0.473000													49	194					0	0	1	0	0
BARHL1	56751	broad.mit.edu	37	9	135462841	135462841	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135462841G>A	ENST00000263610.2	+	2	1205	c.592G>A	c.(592-594)Gag>Aag	p.E198K	BARHL1_ENST00000542090.1_Missense_Mutation_p.E198K	NM_020064.3	NP_064448.1	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	198						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(2)|lung(2)|skin(3)	8				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		GCGCAGCTTCGAGCGGCAGAA	0.662000													4	18					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30954233	30954233	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:30954233C>T	ENST00000295055.8	-	21	2136	c.1960G>A	c.(1960-1962)Gga>Aga	p.G654R	CAPN13_ENST00000534090.2_Missense_Mutation_p.G654R	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	654	EF-hand 2.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AGGTAGAGTCCTTTTCCATCC	0.547000													4	13					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44590866	44590866	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44590866C>T	ENST00000421176.3	+	5	1451	c.1235C>T	c.(1234-1236)tCa>tTa	p.S412L	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				TATATGAATTCACAGGGCCAT	0.433000													58	137					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744734	70744734	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:70744734G>A	ENST00000260126.3	-	2	881	c.175C>T	c.(175-177)Ccg>Tcg	p.P59S	SLCO5A1_ENST00000530307.1_Missense_Mutation_p.P59S|SLCO5A1_ENST00000528658.1_5'UTR|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.P59S	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	59						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCAAAGGCCGGGTTGGCGTCT	0.652000											OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	49					0	0	1	0	0
TBPL2	387332	broad.mit.edu	37	14	55903341	55903341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:55903341G>A	ENST00000247219.5	-	2	616	c.546C>T	c.(544-546)tcC>tcT	p.S182S		NM_199047.2	NP_950248.1	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	182					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8						TGGGAGTTATGGATGCCAGAG	0.438000													42	73					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168112721	168112721	+	Missense_Mutation	SNP	C	C	T	rs143177032		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:168112721C>T	ENST00000519560.1	-	31	3945	c.3526G>A	c.(3526-3528)Gtc>Atc	p.V1176I	SLIT3_ENST00000332966.8_Missense_Mutation_p.V1183I|SLIT3_ENST00000404867.3_Missense_Mutation_p.V1176I	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1176	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGGGTCGGACCTTGGCGGAG	0.607000													26	65					0	0	1	0	0
CCR5	1234	broad.mit.edu	37	3	46415189	46415189	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46415189C>T	ENST00000343801.4	+	3	1153	c.796C>T	c.(796-798)Ctg>Ttg	p.L266L	CCR5_ENST00000292303.4_Silent_p.L266L|CCR5_ENST00000445772.1_Silent_p.L266L|RP11-24F11.2_ENST00000451485.1_RNA	NM_000579.3	NP_000570.1	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5 (gene/pseudogene)	266					cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			central_nervous_system(1)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	ATTCTTTGGCCTGAATAATTG	0.468000													123	352					0	0	1	0	0
METTL3	56339	broad.mit.edu	37	14	21967278	21967278	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21967278G>A	ENST00000298717.4	-	10	1673	c.1522C>T	c.(1522-1524)Cgt>Tgt	p.R508C	TOX4_ENST00000405508.1_3'UTR|TOX4_ENST00000262709.3_3'UTR	NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	508					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		CTGGTGGAACGAACCTAGGAA	0.373000													24	39					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67801997	67801997	+	Silent	SNP	G	G	A	rs138108492	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:67801997G>A	ENST00000544246.1	-	2	1267	c.576C>T	c.(574-576)atC>atT	p.I192I	PCDH9_ENST00000377865.2_Silent_p.I192I|PCDH9_ENST00000377861.3_Silent_p.I192I|PCDH9_ENST00000456367.1_Silent_p.I192I|PCDH9_ENST00000328454.5_Silent_p.I192I	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	192	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GAGTTTCCACGATATCCAGTC	0.428000													53	166					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104512146	104512146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:104512146G>A	ENST00000372582.1	+	5	1375	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E207K	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	207	Ig-like C2-type 2.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGTTCAAGAAGAAGATGGAGG	0.333000													20	26					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117768856	117768856	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:117768856C>T	ENST00000317775.6	-	2	704	c.19G>A	c.(19-21)Ggt>Agt	p.G7S	NOS1_ENST00000344089.3_Missense_Mutation_p.G7S|NOS1_ENST00000338101.4_Missense_Mutation_p.G7S	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	7	Interaction with NOSIP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGCTGAACACCGAACATGTGA	0.527000													10	105					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30935870	30935870	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:30935870G>A	ENST00000355537.3	+	2	1548	c.1401G>A	c.(1399-1401)ggG>ggA	p.G467G		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					AAGCGCTGGGGAAGCTGCTGT	0.642000													17	61					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33114106	33114106	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33114106G>A	ENST00000307363.5	-	2	319	c.175C>T	c.(175-177)Cgt>Tgt	p.R59C	GLB1_ENST00000399402.3_Missense_Mutation_p.R29C|GLB1_ENST00000307377.8_Missense_Mutation_p.R59C|GLB1_ENST00000445488.2_Missense_Mutation_p.R107C	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	59			R -> C (in GM1G1; protein enzymatically inactive; severe mutation).|R -> H (in GM1G1; with cardiac involvement in some patients; protein enzymatically inactive; severe mutation).		carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				CGGGGCACACGGGAGTAGTGA	0.542000													19	69					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9049049	9049049	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9049049G>A	ENST00000397910.4	-	5	32785	c.32582C>T	c.(32581-32583)tCc>tTc	p.S10861F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10863	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGCTGAACTGGATTCTGCCCC	0.483000													37	97					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23811825	23811825	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:23811825C>T	ENST00000354639.3	+	15	2288	c.1824C>T	c.(1822-1824)tcC>tcT	p.S608S	STK31_ENST00000433467.2_Silent_p.S631S|STK31_ENST00000355870.3_Silent_p.S631S|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Silent_p.S608S	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	631							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						ACTTGCTATCCATTAAGAAGA	0.313000													26	67					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75675519	75675519	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:75675519G>A	ENST00000319410.5	-	3	370	c.249C>T	c.(247-249)gcC>gcT	p.A83A	KARS_ENST00000568378.1_Intron|KARS_ENST00000302445.3_Silent_p.A55A	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	55					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	TGTGGTTGGTGGCAGCAGCAG	0.537000													13	50					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87029421	87029421	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:87029421C>T	ENST00000370563.3	+	4	568	c.526C>T	c.(526-528)Cgt>Tgt	p.R176C	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	176						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GCCTTTCTACCGTGCTAAGTC	0.398000													27	75					0	0	1	0	0
CHRNB3	1142	broad.mit.edu	37	8	42587083	42587083	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42587083G>A	ENST00000289957.2	+	5	761	c.633G>A	c.(631-633)ggG>ggA	p.G211G		NM_000749.3	NP_000740.1	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta 3 (neuronal)	211					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			endometrium(4)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GGATGAAGGGGAACAGAAGGG	0.468000													8	138					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39960881	39960881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39960881C>T	ENST00000599117.1	+	18	1864	c.1497C>T	c.(1495-1497)ttC>ttT	p.F499F	SUPT5H_ENST00000359191.6_Silent_p.F495F|SUPT5H_ENST00000402194.2_Silent_p.F495F|SUPT5H_ENST00000598725.1_Silent_p.F499F|SUPT5H_ENST00000432763.2_Silent_p.F499F			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	499	KOW 3.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGGAGAATTTCGTTATCCTGT	0.552000													52	122					0	0	1	0	0
JDP2	122953	broad.mit.edu	37	14	75928233	75928233	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75928233G>A	ENST00000435893.2	+	3	579	c.306_splice	c.e3+1	p.R102_splice	JDP2_ENST00000437176.1_Splice_Site_p.R102_splice|JDP2_ENST00000267569.5_Splice_Site_p.R113_splice|JDP2_ENST00000419727.2_Splice_Site_p.R102_splice	NM_001135047.1|NM_130469.3	NP_001128519.1|NP_569736.1	Q8WYK2	JDP2_HUMAN	Jun dimerization protein 2	102	Leucine-zipper.					nucleus	sequence-specific DNA binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(234;0.0296)		TTCTGCAGCGGGTGAGCTGAC	0.582000													3	12					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25336839	25336839	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25336839C>T	ENST00000546682.1	+	0	942				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						GGAATGTGATCTCTGTTGGGT	0.517000													11	27					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49244651	49244651	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:49244651C>T	ENST00000406846.2	-	4	470	c.351G>A	c.(349-351)caG>caA	p.Q117Q	FSHR_ENST00000304421.4_Silent_p.Q117Q|FSHR_ENST00000346173.3_Silent_p.Q117Q	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	117					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TGGGAAGGTTCTGGAAGGCCT	0.393000									Gonadal Dysgenesis, 46 XX				19	66					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68701305	68701305	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:68701305C>T	ENST00000255078.3	+	10	1572	c.1461C>T	c.(1459-1461)ccC>ccT	p.P487P	IGHMBP2_ENST00000541229.1_3'UTR	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	487					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CGGGTGTGCCCCTGCTCTTGG	0.647000													6	12					0	0	1	0	0
PROM1	8842	broad.mit.edu	37	4	16026826	16026826	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:16026826C>T	ENST00000505450.1	-	5	1204	c.592G>A	c.(592-594)Gaa>Aaa	p.E198K	PROM1_ENST00000502943.1_5'UTR|PROM1_ENST00000543373.1_Missense_Mutation_p.E198K|PROM1_ENST00000539194.1_Missense_Mutation_p.E207K|PROM1_ENST00000510224.1_Missense_Mutation_p.E207K|PROM1_ENST00000540805.1_Missense_Mutation_p.E207K|PROM1_ENST00000447510.2_Missense_Mutation_p.E207K|PROM1_ENST00000508167.1_Missense_Mutation_p.E198K	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	207					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						TCTGGAGTTTCATTCAAGAGA	0.398000													52	113					0	0	1	0	0
C15orf32	145858	broad.mit.edu	37	15	93016251	93016251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:93016251G>A	ENST00000333334.2	+	2	938	c.443G>A	c.(442-444)gGa>gAa	p.G148E	C15orf32_ENST00000556865.1_Missense_Mutation_p.G148E	NM_153040.2	NP_694585.1	Q32M92	CO032_HUMAN	chromosome 15 open reading frame 32	148										endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	12	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			TTCAATTGCGGAAGCATAGAG	0.468000													73	78					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62066599	62066599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:62066599G>A	ENST00000404929.1	-	3	1551	c.1540C>T	c.(1540-1542)Ccc>Tcc	p.P514S	FAM161A_ENST00000405894.3_Missense_Mutation_p.P514S	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	514					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GTGGGCACGGGAGGGTTGCAG	0.478000													28	77					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717102	142717102	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:142717102C>T	ENST00000381779.4	-	2	2048	c.1823G>A	c.(1822-1824)cGa>cAa	p.R608Q	SLITRK4_ENST00000356928.1_Missense_Mutation_p.R608Q|SLITRK4_ENST00000338017.4_Missense_Mutation_p.R608Q	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	608						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGGACTTCGAATGGGACC	0.418000													47	43					0	0	1	0	0
SPDL1	54908	broad.mit.edu	37	5	169021292	169021292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:169021292C>T	ENST00000265295.4	+	5	954	c.675C>T	c.(673-675)gcC>gcT	p.A225A	SPDL1_ENST00000510751.1_3'UTR	NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		ACTATAATGCCCTAGAGGTAC	0.348000													13	40					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108626796	108626796	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:108626796C>T	ENST00000264047.2	+	9	1498	c.1222C>T	c.(1222-1224)Ctc>Ttc	p.L408F	SLC5A7_ENST00000540517.1_Missense_Mutation_p.L303F|SLC5A7_ENST00000409059.1_Missense_Mutation_p.L408F	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	408					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	GCTCTGGTACCTCAGTTCTGA	0.473000													16	90					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29455288	29455288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29455288C>T	ENST00000389048.3	-	15	3420	c.2514G>A	c.(2512-2514)ctG>ctA	p.L838L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	838	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CTGCAATGATCAGGGGCACCG	0.572000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				15	35					0	0	1	0	0
TBC1D19	55296	broad.mit.edu	37	4	26719613	26719613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:26719613C>T	ENST00000264866.4	+	14	1291	c.1013C>T	c.(1012-1014)gCc>gTc	p.A338V	TBC1D19_ENST00000511789.1_Missense_Mutation_p.A273V	NM_018317.2	NP_060787.2	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	338	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	17		Breast(46;0.0503)				TTCAACAGTGCCTCGCCACCA	0.299000													33	97					0	0	1	0	0
THSD7A	221981	broad.mit.edu	37	7	11632983	11632983	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:11632983C>T	ENST00000423059.3	-	3	1420	c.1169G>A	c.(1168-1170)cGa>cAa	p.R390Q		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	390	TSP type-1 3.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCTGATGGTTCGTGTCCTTAC	0.512000										HNSCC(18;0.044)			22	42					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187629015	187629015	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:187629015G>A	ENST00000441802.2	-	2	2176	c.1967C>T	c.(1966-1968)cCa>cTa	p.P656L		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	656	Cadherin 5.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GATATATAATGGTGTGGCAAA	0.448000										HNSCC(5;0.00058)			30	74					0	0	1	0	0
ACSS1	84532	broad.mit.edu	37	20	25003624	25003624	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:25003624G>A	ENST00000537502.1	-	3	2194	c.663C>T	c.(661-663)atC>atT	p.I221I	ACSS1_ENST00000432802.2_Silent_p.I304I|ACSS1_ENST00000542618.1_Silent_p.I183I|ACSS1_ENST00000323482.4_Silent_p.I304I			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	304					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGGTATGGACGATGCCCTTGG	0.637000													9	26					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21990920	21990920	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21990920G>A	ENST00000327430.3	-	2	3236	c.2942C>T	c.(2941-2943)tCt>tTt	p.S981F	SALL2_ENST00000450879.2_Intron|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	981							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		AGGGACTAGAGAAAGAGCAGC	0.562000													25	66					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103274171	103274171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:103274171C>T	ENST00000233969.2	+	2	580	c.438C>T	c.(436-438)ctC>ctT	p.L146L		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	146						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						TGTACCTCCTCCCACCCATCG	0.458000													63	237					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189850395	189850395	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189850395C>T	ENST00000304636.3	+	4	508	c.338C>T	c.(337-339)cCt>cTt	p.P113L	COL3A1_ENST00000317840.5_Missense_Mutation_p.P113L	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	113					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTTTAGGGCCCTCCTGGTATT	0.413000													7	13					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123629551	123629551	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123629551G>A	ENST00000369043.3	-	8	1031	c.945C>T	c.(943-945)ttC>ttT	p.F315F	ATE1_ENST00000224652.6_Silent_p.F315F|ATE1_ENST00000543447.1_Silent_p.F200F|ATE1_ENST00000481784.1_5'UTR|ATE1_ENST00000540606.1_Silent_p.F308F|ATE1_ENST00000369040.3_Silent_p.F219F|ATE1_ENST00000535655.1_Silent_p.F16F	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	315					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				GGAATCTTGTGAACTGCAGTC	0.338000													35	69					0	0	1	0	0
IL3	3562	broad.mit.edu	37	5	131398405	131398405	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:131398405G>A	ENST00000296870.2	+	5	558	c.380G>A	c.(379-381)cGg>cAg	p.R127Q		NM_000588.3	NP_000579.2	P08700	IL3_HUMAN	interleukin 3 (colony-stimulating factor, multiple)	127					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)	10		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	AATGAATTCCGGAGGAAACTG	0.483000											OREG0016762	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	117					0	0	1	0	0
SLC7A10	56301	broad.mit.edu	37	19	33702229	33702229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:33702229G>A	ENST00000253188.3	-	7	1064	c.918C>T	c.(916-918)ttC>ttT	p.F306F		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10	306					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					GCTTCTCCCCGAAGGTCTGGG	0.622000													9	47					0	0	1	0	0
BLNK	29760	broad.mit.edu	37	10	98006765	98006765	+	Missense_Mutation	SNP	C	C	T	rs143109144	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98006765C>T	ENST00000224337.5	-	2	229	c.88G>A	c.(88-90)Ggt>Agt	p.G30S	BLNK_ENST00000413476.2_Missense_Mutation_p.G30S|BLNK_ENST00000495266.1_Missense_Mutation_p.G30S|BLNK_ENST00000427367.2_Missense_Mutation_p.G30S|BLNK_ENST00000371176.2_Missense_Mutation_p.G30S	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	30					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ATTATTCCACCTTCATTGTTT	0.254000													17	89					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140123538	140123538	+	Silent	SNP	C	C	T	rs142111816	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:140123538C>T	ENST00000458420.3	+	4	757	c.567C>T	c.(565-567)tcC>tcT	p.S189S		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	189	Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						AGGACTGCTCCCCACAGTACA	0.537000										HNSCC(16;0.037)			19	89					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69683824	69683824	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:69683824C>T	ENST00000265403.7	+	2	823	c.796C>T	c.(796-798)Cct>Tct	p.P266S	UGT2B10_ENST00000458688.2_Missense_Mutation_p.P182S	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	266					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TTTTAAATTTCCTCATCCATT	0.383000													76	205					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3905604	3905604	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3905604G>A	ENST00000450849.2	+	4	776	c.309G>A	c.(307-309)gaG>gaA	p.E103E	ATCAY_ENST00000398448.3_Silent_p.E109E|ATCAY_ENST00000600960.1_Silent_p.E103E|ATCAY_ENST00000301260.6_Silent_p.E103E	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	103					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCCCGATGAGACCGACTCGC	0.582000													28	70					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77973147	77973147	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:77973147C>T	ENST00000354212.4	-	9	1609	c.1356G>A	c.(1354-1356)gtG>gtA	p.V452V	MAGI2_ENST00000535697.1_Silent_p.V289V|MAGI2_ENST00000419488.1_Silent_p.V452V|MAGI2_ENST00000536571.1_Silent_p.V284V|MAGI2_ENST00000522391.1_Silent_p.V452V	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	452	PDZ 2.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TCACACTTTTCACCTGCAGAA	0.438000													25	61					0	0	1	0	0
HACE1	57531	broad.mit.edu	37	6	105219820	105219820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:105219820G>A	ENST00000262903.4	-	18	2270	c.1994C>T	c.(1993-1995)tCc>tTc	p.S665F	HACE1_ENST00000369125.2_Intron|HACE1_ENST00000517995.1_5'UTR	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	665	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		CTTGTAGAAGGATCGTGTGAA	0.363000													28	48					0	0	1	0	0
ZNF441	126068	broad.mit.edu	37	19	11891923	11891923	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11891923C>T	ENST00000357901.4	+	4	1386	c.1284C>T	c.(1282-1284)ttC>ttT	p.F428F	ZNF441_ENST00000454339.2_Silent_p.F361F	NM_152355.2	NP_689568.2	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GAAAAGCCTTCATTTGTTGCA	0.368000													22	49					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65252522	65252522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65252522C>T	ENST00000389722.3	-	16	3762	c.3709G>A	c.(3709-3711)Gag>Aag	p.E1237K	SPTB_ENST00000389720.3_Missense_Mutation_p.E1237K|SPTB_ENST00000389721.5_Missense_Mutation_p.E1237K|SPTB_ENST00000556626.1_Missense_Mutation_p.E1237K|SPTB_ENST00000542895.1_Missense_Mutation_p.E1237K	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1237					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AGGTTTCCCTCAGCTACCAGC	0.562000													16	286					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136564711	136564711	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136564711G>A	ENST00000264162.2	-	9	4170	c.4160C>T	c.(4159-4161)tCt>tTt	p.S1387F		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1387	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity	p.S1387F(1)		breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATATGCAGCAGAAGCTGCACT	0.567000													16	81					0	0	1	0	0
OR7D4	125958	broad.mit.edu	37	19	9324768	9324768	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9324768G>A	ENST00000308682.2	-	1	774	c.746C>T	c.(745-747)tCc>tTc	p.S249F		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						ATAGAACAAGGAGACCACACA	0.517000													24	52					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38938645	38938645	+	Silent	SNP	G	G	A	rs145915658		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38938645G>A	ENST00000302328.3	-	14	2292	c.2094C>T	c.(2092-2094)gtC>gtT	p.V698V	SCN11A_ENST00000456224.3_Silent_p.V698V|SCN11A_ENST00000444237.2_Silent_p.V698V|SCN11A_ENST00000450244.1_Silent_p.V698V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	698					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CAAGGGCTCCGACAGAGTTGC	0.433000													16	54					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141163939	141163939	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141163939C>T	ENST00000514251.1	+	4	2988	c.2709C>T	c.(2707-2709)ttC>ttT	p.F903F	ZBTB38_ENST00000441582.2_Silent_p.F903F|ZBTB38_ENST00000321464.5_Silent_p.F904F			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	903					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.F903F(1)		breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						GTGAAGTGTTCGATGACGCAA	0.507000													24	53					0	0	1	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79629664	79629664	+	Missense_Mutation	SNP	C	C	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:79629664C>A	ENST00000263849.4	+	9	1016	c.914C>A	c.(913-915)aCt>aAt	p.T305N		NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	305																	GAGTGTGGGACTAAATACCCT	0.388000													58	131					2.60599e-31	2.62408e-31	1	1	0
AIFM3	150209	broad.mit.edu	37	22	21333929	21333929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:21333929C>T	ENST00000399167.2	+	18	1830	c.1590C>T	c.(1588-1590)ggC>ggT	p.G530G	AIFM3_ENST00000335375.5_Silent_p.G518G|AIFM3_ENST00000440238.2_Silent_p.G530G|AIFM3_ENST00000333607.6_Silent_p.G530G|AIFM3_ENST00000405089.1_Silent_p.G536G|AIFM3_ENST00000399163.2_Silent_p.G530G|LZTR1_ENST00000479606.1_3'UTR|AIFM3_ENST00000465606.1_3'UTR	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			ACGGAGAAGGCTTCGACGACG	0.642000													55	162					0	0	1	0	0
HLA-G	3135	broad.mit.edu	37	6	29797602	29797602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29797602C>T	ENST00000428701.1	+	6	1083	c.905C>T	c.(904-906)tCc>tTc	p.S302F	HLA-G_ENST00000360323.6_Missense_Mutation_p.S302F|HLA-G_ENST00000376828.2_Missense_Mutation_p.S307F|HLA-G_ENST00000376815.3_Missense_Mutation_p.S118F|HLA-G_ENST00000376818.3_Missense_Mutation_p.S210F	NM_002127.5	NP_002118.1	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	302	Connecting peptide.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(5)|skin(1)	21						GAGCAGTCTTCCCTGCCCACC	0.582000													11	101					0	0	1	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806670	6806670	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6806670C>T	ENST00000307401.4	+	1	423	c.402C>T	c.(400-402)acC>acT	p.T134T		NM_001004489.2	NP_001004489.1	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CATACATGACCCTCATGAGCT	0.527000													19	53					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488413	1488413	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:1488413G>A	ENST00000345913.4	+	9	1475	c.1384G>A	c.(1384-1386)Gcc>Acc	p.A462T	TPO_ENST00000382198.1_Missense_Mutation_p.A289T|TPO_ENST00000349624.3_Missense_Mutation_p.A289T|TPO_ENST00000329066.4_Missense_Mutation_p.A462T|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000382201.3_Missense_Mutation_p.A462T|TPO_ENST00000337415.3_Missense_Mutation_p.A462T|TPO_ENST00000346956.3_Missense_Mutation_p.A462T	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	462					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGACCCGAGGCCTTCCAGCA	0.592000													17	26					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115573981	115573981	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:115573981C>T	ENST00000371900.4	+	4	561	c.473C>T	c.(472-474)tCg>tTg	p.S158L		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	158					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	AATTGTTCTTCGTGGTCAGAT	0.303000													64	34					0	0	1	0	0
ARL10	285598	broad.mit.edu	37	5	175793522	175793522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:175793522C>T	ENST00000310389.5	+	2	419	c.323C>T	c.(322-324)cCc>cTc	p.P108L		NM_173664.4	NP_775935.1	Q8N8L6	ARL10_HUMAN	ADP-ribosylation factor-like 10	108							GTP binding			endometrium(2)|lung(1)|ovary(1)	4	all_cancers(89;0.0064)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.0965)		GGCCACATCCCCACCTGGGGC	0.637000													10	52					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47680242	47680242	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47680242G>A	ENST00000283303.2	+	5	708	c.450G>A	c.(448-450)gtG>gtA	p.V150V	GPR115_ENST00000327753.3_Silent_p.V150V|GPR115_ENST00000371220.1_Silent_p.V207V	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	150					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CTGACATGGTGAAATCATCAG	0.373000													35	106					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53165751	53165751	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53165751C>T	ENST00000332411.2	-	6	1220	c.1167G>A	c.(1165-1167)agG>agA	p.R389R		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	389	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CATCCCCATGCCTGCCAGCTG	0.507000													39	73					0	0	1	0	0
CLUL1	27098	broad.mit.edu	37	18	641370	641370	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:641370G>A	ENST00000581619.1	+	7	1960	c.1113G>A	c.(1111-1113)gcG>gcA	p.A371A	CLUL1_ENST00000579494.1_Silent_p.A346A|C18orf56_ENST00000585033.1_3'UTR|CLUL1_ENST00000338387.7_Silent_p.A346A|CLUL1_ENST00000540035.1_Silent_p.A398A|CLUL1_ENST00000400606.2_Silent_p.A346A			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	346					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						TAGACGAGGCGATCAGGTTGG	0.493000													21	81					0	0	1	0	0
DDX25	29118	broad.mit.edu	37	11	125780323	125780323	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:125780323G>A	ENST00000263576.6	+	7	727	c.572G>A	c.(571-573)gGa>gAa	p.G191E	RP11-680F20.9_ENST00000533033.2_RNA|DDX25_ENST00000525943.1_3'UTR	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	191	Helicase ATP-binding.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		GAGCAGATGGGAAAATTCTGT	0.483000													11	102					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10081488	10081488	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10081488C>T	ENST00000287647.3	+	9	747	c.654C>T	c.(652-654)atC>atT	p.I218I	FANCD2_ENST00000383806.1_Silent_p.I218I|FANCD2_ENST00000383807.1_Silent_p.I218I|FANCD2_ENST00000419585.1_Silent_p.I218I|FANCD2_ENST00000431693.1_Silent_p.I218I|FANCD2_ENST00000438741.1_3'UTR	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	218	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TACCTGAGATCCTAGGGGATT	0.512000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	81					0	0	1	0	0
FAM153C	653316	broad.mit.edu	37	5	177473889	177473889	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:177473889C>T	ENST00000398106.2	+	9	743	c.290C>T	c.(289-291)tCc>tTc	p.S97F	FAM153C_ENST00000511189.1_Missense_Mutation_p.S126F|FAM153C_ENST00000507848.1_Missense_Mutation_p.S97F					family with sequence similarity 153, member C											kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAAGTCCTTCCTCTGCACCT	0.527000													26	82					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167659303	167659303	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:167659303G>A	ENST00000367854.3	+	4	547	c.216G>A	c.(214-216)gcG>gcA	p.A72A	RCSD1_ENST00000537350.1_Silent_p.A42A	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	72										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CACCCAATGCGAGCCACCCTC	0.453000													36	109					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	148037913	148037913	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:148037913C>T	ENST00000370460.2	+	11	2817	c.2338C>T	c.(2338-2340)Cct>Tct	p.P780S	AFF2_ENST00000370457.5_Missense_Mutation_p.P747S|AFF2_ENST00000342251.3_Missense_Mutation_p.P747S|AFF2_ENST00000286437.5_Missense_Mutation_p.P421S	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	780					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					AACATTTTCACCTATTCCTGT	0.458000													26	40					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160862250	160862250	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160862250G>A	ENST00000283243.7	-	11	1953	c.1747C>T	c.(1747-1749)Caa>Taa	p.Q583*	PLA2R1_ENST00000392771.1_Nonsense_Mutation_p.Q583*	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	583	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GTATCATTTTGGTCCTGAAGA	0.448000													9	130					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	161966466	161966466	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161966466C>T	ENST00000366892.1	-	10	1182	c.1087G>A	c.(1087-1089)Gga>Aga	p.G363R	PARK2_ENST00000366894.1_Intron|PARK2_ENST00000366898.1_Intron|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000366897.1_Intron|PARK2_ENST00000338468.3_Intron			O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	0					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		cttcgttgtccatactgtgag	0.363000													9	10					0	0	1	0	0
KLRC4-KLRK1	100528032	broad.mit.edu	37	12	10560269	10560269	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:10560269G>A	ENST00000539300.1	-	4	433	c.434C>T	c.(433-435)tCt>tTt	p.S145F	KLRC4_ENST00000309384.1_Silent_p.L154L																							AAGCAGATCAGAGTTCTTCGA	0.348000													30	267					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103377716	103377716	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:103377716C>T	ENST00000358392.2	-	54	4438	c.4122_splice	c.e54+1	p.R1374_splice	COL11A1_ENST00000370096.3_Splice_Site_p.R1362_splice|COL11A1_ENST00000512756.1_Splice_Site_p.R1246_splice|COL11A1_ENST00000353414.4_Splice_Site_p.R1323_splice	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1362	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GAAACTTACTCGTTTTCCAGG	0.363000													8	23					0	0	1	0	0
RFC1	5981	broad.mit.edu	37	4	39304389	39304389	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:39304389G>A	ENST00000381897.1	-	17	2444	c.2311C>T	c.(2311-2313)Cgt>Tgt	p.R771C	RFC1_ENST00000349703.2_Missense_Mutation_p.R770C	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	771					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						CTTTGAAAACGAAGATCAAAA	0.318000													16	59					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89651233	89651233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89651233G>A	ENST00000268720.5	+	7	914	c.784G>A	c.(784-786)Gac>Aac	p.D262N	CPNE7_ENST00000319518.8_Missense_Mutation_p.D187N	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	262	C2 2.				lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GGTCAACGACGACCAGGGCTT	0.657000													6	28					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18112930	18112930	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:18112930G>A	ENST00000403915.1	+	3	1106	c.655G>A	c.(655-657)Gat>Aat	p.D219N	KCNS3_ENST00000465292.1_Intron|KCNS3_ENST00000304101.4_Missense_Mutation_p.D219N			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	219					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGAAGTGGATGATCCGGTGCT	0.572000													19	78					0	0	1	0	0
ENKUR	219670	broad.mit.edu	37	10	25284783	25284783	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25284783C>T	ENST00000331161.4	-	3	458	c.239G>A	c.(238-240)cGg>cAg	p.R80Q	ENKUR_ENST00000376363.1_Missense_Mutation_p.R80Q	NM_145010.3	NP_659447.1	Q8TC29	ENKUR_HUMAN	enkurin, TRPC channel interacting protein	80						cilium|flagellum	calmodulin binding|SH3 domain binding			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						GGGCACGTTCCGATCAAAGTT	0.333000													13	133					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242815135	242815135	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242815135C>T	ENST00000343216.3	+	2	1456	c.1428C>T	c.(1426-1428)ttC>ttT	p.F476F		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	476						integral to membrane											CCATCCCCTTCGCAGTCTTCG	0.627000													19	99					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119927487	119927487	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119927487C>T	ENST00000361035.4	+	5	694	c.411C>T	c.(409-411)ctC>ctT	p.L137L	HAO2_ENST00000325945.3_Silent_p.L124L	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	124	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		CCGAAGGCCTCCGATGGTTCC	0.488000													15	126					0	0	1	0	0
EFCAB1	79645	broad.mit.edu	37	8	49643999	49643999	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:49643999C>T	ENST00000262103.3	-	2	202	c.122G>A	c.(121-123)aGg>aAg	p.R41K	EFCAB1_ENST00000433756.1_Intron|EFCAB1_ENST00000523092.1_Intron|EFCAB1_ENST00000521002.1_Intron	NM_024593.3	NP_078869.1	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1	41							calcium ion binding			endometrium(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(2)	14		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				CAGACCTTGCCTCTCTACTCC	0.358000													13	48					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486458	125486458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125486458C>T	ENST00000259466.1	+	1	190	c.190C>T	c.(190-192)Ctc>Ttc	p.L64F		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						GTACTTTTTTCTCAGCAACTT	0.453000													27	74					0	0	1	0	0
ATP6V1F	9296	broad.mit.edu	37	7	128503058	128503058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:128503058C>T	ENST00000492758.1	+	1	101	c.100C>T	c.(100-102)Ccc>Tcc	p.P34S	ATP6V1F_ENST00000249289.4_Missense_Mutation_p.P34S	NM_001198909.1	NP_001185838.1	Q16864	VATF_HUMAN	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F	34					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|membrane fraction|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATPase activity, uncoupled|hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding|proton-transporting ATPase activity, rotational mechanism			lung(1)|ovary(1)|prostate(1)	3						GAACCGCCATCCCAATTTCCT	0.582000											OREG0018299	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	78					0	0	1	0	0
NUP210P1	255330	broad.mit.edu	37	3	126386152	126386152	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:126386152C>T	ENST00000357061.3	+	0	604					NR_034158.1																						GGTCTGTCACCAAGCGGGACA	0.602000													13	28					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827096	96827096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:96827096C>T	ENST00000371270.3	-	3	444	c.350G>A	c.(349-351)gGa>gAa	p.G117E	CYP2C8_ENST00000539050.1_Missense_Mutation_p.G31E|CYP2C8_ENST00000535898.1_Missense_Mutation_p.G15E	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	117					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CCATCTCTTTCCATTGCTGGA	0.488000													27	77					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38967280	38967280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:38967280G>A	ENST00000357387.3	-	14	1231	c.1201C>T	c.(1201-1203)Cgt>Tgt	p.R401C	RICTOR_ENST00000296782.5_Missense_Mutation_p.R401C	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	401					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					AGTCCATTACGAATAAATGCA	0.343000													85	202					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4433534	4433534	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4433534C>T	ENST00000301280.5	+	13	2772	c.2671C>T	c.(2671-2673)Cag>Tag	p.Q891*		NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	891	Binds to p60.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACGACGGCCAGGTGAGGTG	0.552000								Chromatin Structure					14	33					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518403	113518403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113518403G>A	ENST00000284601.3	-	4	2812	c.2744C>T	c.(2743-2745)cCt>cTt	p.P915L		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	915					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTTGGAAAAAGGAGAGCTATT	0.403000													34	101					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8193951	8193951	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:8193951G>A	ENST00000600128.1	-	18	2671	c.2257C>T	c.(2257-2259)Ccc>Tcc	p.P753S	FBN3_ENST00000601739.1_Missense_Mutation_p.P753S|FBN3_ENST00000270509.2_Missense_Mutation_p.P753S			Q75N90	FBN3_HUMAN	fibrillin 3	753	EGF-like 9; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TGGAAGCCGGGGGGGCAGGAG	0.602000													25	67					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785468	134785468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:134785468G>A	ENST00000537858.1	-	2	362	c.162C>T	c.(160-162)tcC>tcT	p.S54S		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	54	FHA.									breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTGACGGCGGGAGAGGCGAG	0.657000													6	64					0	0	1	0	0
EMCN	51705	broad.mit.edu	37	4	101396232	101396232	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:101396232C>T	ENST00000296420.4	-	3	400	c.222G>A	c.(220-222)ctG>ctA	p.L74L	EMCN_ENST00000502327.1_5'UTR|EMCN_ENST00000305864.3_Silent_p.L74L|EMCN_ENST00000511970.1_Silent_p.L74L	NM_001159694.1|NM_016242.3	NP_001153166.1|NP_057326.2	Q9ULC0	MUCEN_HUMAN	endomucin	74	Thr-rich.					extracellular region|integral to membrane|plasma membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		CTGTTGACATCAGAGACATTT	0.229000													7	58					0	0	1	0	0
OR52I1	390037	broad.mit.edu	37	11	4615509	4615509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:4615509G>A	ENST00000450052.2	+	2	313	c.313G>A	c.(313-315)Gtg>Atg	p.V105M	OR52I1_ENST00000530443.2_Missense_Mutation_p.V81M			Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I, member 1	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	15		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCCTCCTCCGTGGTACCCAA	0.502000													30	176					0	0	1	0	0
SUOX	6821	broad.mit.edu	37	12	56396389	56396389	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:56396389C>T	ENST00000394109.3	+	2	837	c.113C>T	c.(112-114)cCc>cTc	p.P38L	SUOX_ENST00000266971.3_Missense_Mutation_p.P38L|SUOX_ENST00000356124.4_Missense_Mutation_p.P38L|SUOX_ENST00000550478.1_3'UTR|SUOX_ENST00000548274.1_Missense_Mutation_p.P38L|SUOX_ENST00000394115.2_Missense_Mutation_p.P38L|SUOX_ENST00000551841.2_Missense_Mutation_p.P38L			P51687	SUOX_HUMAN	sulfite oxidase	38						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)	15			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			TCATTTCAGCCCCAGCGCCCC	0.537000													51	128					0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231335984	231335984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:231335984G>A	ENST00000444294.3	+	4	2212	c.1354G>A	c.(1354-1356)Gac>Aac	p.D452N	TRIM67_ENST00000366652.2_Missense_Mutation_p.D452N|TRIM67_ENST00000449018.3_Missense_Mutation_p.D390N|TRIM67_ENST00000366653.5_Missense_Mutation_p.D452N	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	452	COS.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CAAGGAGAACGACCCCTCCGG	0.542000													33	79					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58207358	58207358	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:58207358G>A	ENST00000302572.2	-	1	288	c.267C>T	c.(265-267)ttC>ttT	p.F89F		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F89L(1)		large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TATATAATATGAATTTGTCTC	0.453000													24	60					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57185366	57185366	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57185366C>T	ENST00000343433.6	-	20	2246		c.e20-1			NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						ACTTTGATGCCTGTGAAAAAA	0.343000													8	37					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932157	83932157	+	Missense_Mutation	SNP	C	C	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83932157C>G	ENST00000345382.2	-	4	1931	c.1846G>C	c.(1846-1848)Gag>Cag	p.E616Q	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.E609Q	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	616					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						CCACTGGACTCAATTACTGAT	0.542000													7	122					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24573359	24573359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24573359C>T	ENST00000319715.4	+	10	1598	c.1166C>T	c.(1165-1167)tCt>tTt	p.S389F	RBBP6_ENST00000381039.3_Missense_Mutation_p.S389F|RBBP6_ENST00000348022.2_Missense_Mutation_p.S389F	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	389					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TCATTAACTTCTAATCAGTCT	0.438000													8	144					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99690308	99690308	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:99690308C>T	ENST00000524871.1	+	4	379	c.89C>T	c.(88-90)tCa>tTa	p.S30L	CNTN5_ENST00000279463.3_Missense_Mutation_p.S30L|CNTN5_ENST00000528682.1_Missense_Mutation_p.S30L|CNTN5_ENST00000527185.1_Missense_Mutation_p.S30L|CNTN5_ENST00000418526.2_Intron	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	30					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTCTCCACTTCATATGCTGCT	0.338000													16	145					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114057955	114057955	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:114057955G>A	ENST00000462705.1	-	12	2725	c.1904C>T	c.(1903-1905)gCc>gTc	p.A635V	ZBTB20_ENST00000474710.1_Missense_Mutation_p.A708V|ZBTB20_ENST00000357258.3_Missense_Mutation_p.A635V|ZBTB20_ENST00000471418.1_Missense_Mutation_p.A635V|ZBTB20_ENST00000481632.1_Missense_Mutation_p.A635V|ZBTB20_ENST00000464560.1_Missense_Mutation_p.A635V|ZBTB20_ENST00000393785.2_Missense_Mutation_p.A635V	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	708					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CTCCGTGCAGGCCACCACGCC	0.647000													28	55					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144995679	144995679	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144995679G>A	ENST00000322810.4	-	32	8890	c.8721C>T	c.(8719-8721)gcC>gcT	p.A2907A	PLEC_ENST00000354589.3_Silent_p.A2770A|PLEC_ENST00000357649.2_Silent_p.A2774A|PLEC_ENST00000527096.1_Silent_p.A2793A|PLEC_ENST00000356346.3_Silent_p.A2756A|PLEC_ENST00000354958.2_Silent_p.A2748A|PLEC_ENST00000345136.3_Silent_p.A2770A|PLEC_ENST00000436759.2_Silent_p.A2797A|PLEC_ENST00000398774.2_Silent_p.A2738A	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2907	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGGCGCGCTCGGCCGACAGCA	0.657000													20	64					0	0	1	0	0
GALP	85569	broad.mit.edu	37	19	56691959	56691959	+	Missense_Mutation	SNP	G	G	A	rs149853638		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56691959G>A	ENST00000357330.2	+	3	174	c.92G>A	c.(91-93)cGa>cAa	p.R31Q	GALP_ENST00000440823.1_Intron|GALP_ENST00000590002.1_Intron	NM_033106.3	NP_149097.1	Q9UBC7	GALP_HUMAN	galanin-like peptide	31					neuropeptide signaling pathway	extracellular region	hormone activity			lung(4)	4		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		ATCCAGGGACGAGGAGGCTGG	0.607000													10	54					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624387	123624387	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123624387G>A	ENST00000327930.2	-	1	866	c.840C>T	c.(838-840)acC>acT	p.T280T		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TCAGAAGGGGGGTGAGGATAG	0.443000													37	99					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371224	240371224	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240371224G>A	ENST00000319653.9	+	5	3342	c.3112G>A	c.(3112-3114)Gga>Aga	p.G1038R		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1038	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCACTTCCCGGAGCGGGCAT	0.731000													12	47					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122836061	122836061	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:122836061C>T	ENST00000264811.5	-	3	1414	c.996G>A	c.(994-996)acG>acA	p.T332T	TRPC3_ENST00000513531.1_Intron|TRPC3_ENST00000379645.3_Silent_p.T405T	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	320					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CATACCAGATCGTCAAGAGCT	0.512000													16	38					0	0	1	0	0
VIP	7432	broad.mit.edu	37	6	153078241	153078241	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:153078241G>A	ENST00000367244.3	+	6	650	c.478G>A	c.(478-480)Gaa>Aaa	p.E160K	VIP_ENST00000367243.3_Missense_Mutation_p.E159K	NM_003381.3	NP_003372.1	P01282	VIP_HUMAN	vasoactive intestinal peptide	160					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity			haematopoietic_and_lymphoid_tissue(1)|lung(4)|skin(1)	6		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		CAGTGAGGGAGAATCTCCCGA	0.403000													12	18					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140249931	140249931	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140249931G>A	ENST00000398640.2	+	1	1243	c.1243G>A	c.(1243-1245)Gag>Aag	p.E415K	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGACCGCGAGAACGTGTG	0.627000													67	180					0	0	1	0	0
PEX5	5830	broad.mit.edu	37	12	7351705	7351705	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7351705C>T	ENST00000266563.5	+	6	730	c.547C>T	c.(547-549)Cgc>Tgc	p.R183C	PEX5_ENST00000434354.2_Missense_Mutation_p.R198C|PEX5_ENST00000266564.3_Missense_Mutation_p.R183C|PEX5_ENST00000420616.2_Missense_Mutation_p.R183C|PEX5_ENST00000455147.2_Missense_Mutation_p.R183C|PEX5_ENST00000545220.1_Intron|PEX5_ENST00000412720.2_Missense_Mutation_p.R204C	NM_001131024.1	NP_001124496.1	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5	183					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)	21						AGCCACCGATCGCTGGTGAGT	0.532000													5	10					0	0	1	0	0
NUP54	53371	broad.mit.edu	37	4	77055431	77055431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:77055431G>A	ENST00000264883.3	-	5	747	c.607C>T	c.(607-609)Cga>Tga	p.R203*	NUP54_ENST00000458189.2_Nonsense_Mutation_p.R23*|NUP54_ENST00000342467.6_Nonsense_Mutation_p.R23*|NUP54_ENST00000515460.1_5'UTR|NUP54_ENST00000514987.1_Nonsense_Mutation_p.R155*	NM_017426.2	NP_059122.2	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	203	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(3)|skin(1)|stomach(1)	19						TGTTGGCTTCGAATCTCTGTT	0.388000													7	60					0	0	1	0	0
RERGL	79785	broad.mit.edu	37	12	18234369	18234369	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:18234369C>T	ENST00000229002.2	-	6	580	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	RERGL_ENST00000536890.1_3'UTR|RERGL_ENST00000541632.1_5'UTR|RERGL_ENST00000538724.1_Missense_Mutation_p.R124Q	NM_024730.2	NP_079006.1	Q9H628	RERGL_HUMAN	RERG/RAS-like	125	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity			endometrium(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	17						ACAAAGATCTCGTTTGTTGCC	0.408000													35	83					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87179319	87179319	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87179319C>T	ENST00000265724.3	-	14	1819	c.1402G>A	c.(1402-1404)Gaa>Aaa	p.E468K	ABCB1_ENST00000543898.1_Missense_Mutation_p.E404K	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	468	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CCAATGATTTCCCGTAGAAAC	0.408000													36	110					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44053363	44053363	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:44053363G>A	ENST00000306006.6	-	2	817	c.165C>T	c.(163-165)ttC>ttT	p.F55F	ZNF239_ENST00000535642.1_Silent_p.F55F|ZNF239_ENST00000374446.2_Silent_p.F55F|ZNF239_ENST00000426961.1_Silent_p.F55F|ZNF239_ENST00000491188.1_5'UTR	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	55					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding	p.F55F(1)		endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						CAATGTTTTCGAAACAACCAC	0.413000													46	106					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57415743	57415743	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57415743C>T	ENST00000313949.7	+	1	971	c.582C>T	c.(580-582)ctC>ctT	p.L194L	GNAS_ENST00000371075.3_Silent_p.L194L|GNAS-AS1_ENST00000443966.1_RNA|GNAS_ENST00000371098.2_Silent_p.L194L|GNAS-AS1_ENST00000598163.1_RNA|GNAS-AS1_ENST00000424094.2_RNA			P63092	GNAS2_HUMAN	GNAS complex locus	319					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GGGAGGAGCTCAAGCCCGAGG	0.667000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			5	17					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178562966	178562966	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178562966C>T	ENST00000251582.7	-	13	2130	c.2029G>A	c.(2029-2031)Ggg>Agg	p.G677R		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	677	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CAGCGCGTCCCGTCATGCACC	0.642000													34	64					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94032040	94032040	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:94032040G>A	ENST00000282020.4	+	4	929	c.671G>A	c.(670-672)cGa>cAa	p.R224Q	GRID2_ENST00000510992.1_Missense_Mutation_p.R129Q|GRID2_ENST00000505687.1_3'UTR	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	224					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AATCGCTATCGAGACACTCTT	0.408000													35	93					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71016297	71016297	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:71016297C>T	ENST00000334414.6	-	3	625	c.581G>A	c.(580-582)aGa>aAa	p.R194K	PTPRB_ENST00000551525.1_Missense_Mutation_p.R193K|PTPRB_ENST00000550358.1_Missense_Mutation_p.R194K|PTPRB_ENST00000538174.2_5'UTR	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 2.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGCAGCATTTCTGATGAAGGC	0.468000													7	24					0	0	1	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869693	36869693	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36869693G>A	ENST00000279024.4	-	3	1111	c.840C>T	c.(838-840)ggC>ggT	p.G280G		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	280										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				CTTGGGAAAAGCCTAGGAGAG	0.567000													44	97					0	0	1	0	0
ADCK4	79934	broad.mit.edu	37	19	41211272	41211272	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41211272G>A	ENST00000324464.3	-	6	749	c.448C>T	c.(448-450)Cga>Tga	p.R150*	ADCK4_ENST00000243583.6_Intron|ADCK4_ENST00000450541.1_Intron	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	150						integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GCGGCCCCTCGAACTGTACAT	0.607000													27	52					0	0	1	0	0
SPOCK1	6695	broad.mit.edu	37	5	136602719	136602719	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:136602719G>A	ENST00000394945.1	-	3	381	c.212C>T	c.(211-213)cCc>cTc	p.P71L	SPOCK1_ENST00000282223.7_Missense_Mutation_p.P71L	NM_004598.3	NP_004589.1	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	71					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGGCTTGTTGGGATTCCAGTT	0.363000													45	98					0	0	1	0	0
FBXW4	6468	broad.mit.edu	37	10	103433321	103433321	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103433321G>A	ENST00000331272.7	-	3	1084	c.466C>T	c.(466-468)Ctg>Ttg	p.L156L		NM_022039.3	NP_071322.1	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	156					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				breast(3)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	15		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		AAGACTCCCAGAGGCCGACGA	0.512000													42	166					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140752118	140752118	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140752118C>T	ENST00000576222.1	+	1	2288	c.2157C>T	c.(2155-2157)tcC>tcT	p.S719S	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGCTCCTCCAGACCCGCCA	0.557000													17	56					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160035504	160035504	+	Silent	SNP	C	C	T	rs148016866	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160035504C>T	ENST00000263635.6	+	14	2577	c.2340C>T	c.(2338-2340)ggC>ggT	p.G780G	TANC1_ENST00000454300.1_Silent_p.G674G	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	780						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						TTAATGCTGGCCACATCCAGG	0.572000													46	205					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117114252	117114252	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:117114252C>T	ENST00000310357.3	-	6	1855	c.1834G>A	c.(1834-1836)Ggc>Agc	p.G612S	GPRC6A_ENST00000368549.3_Missense_Mutation_p.G541S|GPRC6A_ENST00000530250.1_Missense_Mutation_p.G437S	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	612					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AATATTATGCCAACAACCAGA	0.418000													34	63					0	0	1	0	0
TRGV5	6978	broad.mit.edu	37	7	38389232	38389232	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:38389232C>T	ENST00000390344.2	-	0	275																											TGACTGACTTCGTTCCCCCTT	0.453000													24	61					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98369528	98369528	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:98369528G>A	ENST00000339364.5	-	14	2230	c.2111C>T	c.(2110-2112)cCc>cTc	p.P704L	PIK3AP1_ENST00000371110.2_Missense_Mutation_p.P526L|PIK3AP1_ENST00000371109.3_Missense_Mutation_p.P303L	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	704						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CGTCCTAGGGGGAATGACACT	0.577000													111	255					0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155931555	155931555	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:155931555G>A	ENST00000368316.1	-	15	1751	c.1281C>T	c.(1279-1281)acC>acT	p.T427T	ARHGEF2_ENST00000313695.7_Silent_p.T427T|ARHGEF2_ENST00000368315.3_Silent_p.T456T|ARHGEF2_ENST00000361247.4_Silent_p.T455T|ARHGEF2_ENST00000313667.4_Silent_p.T454T			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	455	DH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CAGGCACTGGGGTTTGGGCCC	0.602000													21	60					0	0	1	0	0
DHX40	79665	broad.mit.edu	37	17	57679906	57679906	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:57679906C>T	ENST00000451169.2	+	18	2045	c.1686C>T	c.(1684-1686)acC>acT	p.T562T	DHX40_ENST00000425628.3_Silent_p.T533T|DHX40_ENST00000251241.4_Silent_p.T610T			Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	610							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CAAAAGAGACCTTTGAAGGCC	0.338000													21	74					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88768356	88768356	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:88768356G>A	ENST00000444431.1	+	0	2956				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										GACACCATCGGGAGCGGCAGA	0.512000													139	358					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40585181	40585181	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40585181C>T	ENST00000260402.3	-	21	2521	c.2272G>A	c.(2272-2274)Gaa>Aaa	p.E758K	PLCB2_ENST00000456256.2_Missense_Mutation_p.E758K|PLCB2_ENST00000557821.1_Missense_Mutation_p.E754K	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	758	C2.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		TTGTTGCCTTCCTCCATCACA	0.562000													24	80					0	0	1	0	0
ASIC4	55515	broad.mit.edu	37	2	220396532	220396532	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220396532C>T	ENST00000358078.4	+	2	1030	c.1016C>T	c.(1015-1017)tCg>tTg	p.S339L	ASIC4_ENST00000473709.1_3'UTR|ASIC4_ENST00000347842.3_Missense_Mutation_p.S339L			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	339						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										CCGCGGAGCTCGCTGCCCAGC	0.622000													24	125					0	0	1	0	0
C10orf76	79591	broad.mit.edu	37	10	103755098	103755098	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103755098G>A	ENST00000370033.4	-	16	1284	c.1165C>T	c.(1165-1167)Cac>Tac	p.H389Y		NM_024541.2	NP_078817.2	Q5T2E6	CJ076_HUMAN	chromosome 10 open reading frame 76	389						integral to membrane				autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|upper_aerodigestive_tract(2)	24		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		TTGCCACTGTGAAGCCTGTGT	0.378000													14	152					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50946288	50946288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50946288C>T	ENST00000374103.4	-	18	2425	c.2340G>A	c.(2338-2340)gcG>gcA	p.A780A	OGDHL_ENST00000490844.1_5'UTR|OGDHL_ENST00000419399.1_Silent_p.A723A|OGDHL_ENST00000432695.1_Silent_p.A571A	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	780					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding	p.A780A(1)		central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TTTCGGGCCTCGCTGACGAGT	0.617000													13	42					0	0	1	0	0
NCR3	259197	broad.mit.edu	37	6	31560469	31560469	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31560469G>A	ENST00000376073.4	-	1	293	c.30C>T	c.(28-30)atC>atT	p.I10I	NCR3_ENST00000491161.1_Intron|NCR3_ENST00000376072.3_Silent_p.I10I|NCR3_ENST00000376071.4_Silent_p.I10I|NCR3_ENST00000340027.5_Silent_p.I10I	NM_001145466.1	NP_001138938.1	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	10					cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			cervix(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)	9						GATGGACCATGATCAAGATGA	0.587000													5	36					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43971011	43971011	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:43971011T>C	ENST00000282406.4	+	23	3548	c.3438T>C	c.(3436-3438)ttT>ttC	p.F1146F		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1146	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGGAAGAATTTTTGAATACTT	0.388000													19	79					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281254	49281254	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:49281254G>A	ENST00000282018.3	+	1	304	c.301G>A	c.(301-303)Ggc>Agc	p.G101S		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	101					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TTATCTTAGAGGCTCCAATTG	0.428000													28	51					0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63276414	63276414	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:63276414G>A	ENST00000415491.2	+	2	820	c.206G>A	c.(205-207)aGa>aAa	p.R69K	LGALS12_ENST00000394618.3_Missense_Mutation_p.R130K|LGALS12_ENST00000425950.2_Missense_Mutation_p.R69K|LGALS12_ENST00000340246.5_Missense_Mutation_p.R131K|LGALS12_ENST00000255684.5_Missense_Mutation_p.R130K	NM_001142537.1	NP_001136009.1	Q96DT0	LEG12_HUMAN	lectin, galactoside-binding, soluble, 12	130	Galectin 1.				apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						GCCCTGCGAAGAGGCTCCAGC	0.592000													18	54					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994357	140994357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140994357C>T	ENST00000285879.4	+	4	1453	c.1167C>T	c.(1165-1167)ttC>ttT	p.F389F	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	389							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGTCTTTTCCAGAGTTCCC	0.488000										HNSCC(15;0.026)			94	86					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14610413	14610413	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:14610413C>T	ENST00000274217.3	+	8	1181	c.1061C>T	c.(1060-1062)cCa>cTa	p.P354L		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	354										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					TACCACATTCCAGTCTTTTAA	0.532000													15	58					0	0	1	0	0
NRIP1	8204	broad.mit.edu	37	21	16339859	16339859	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:16339859G>A	ENST00000400202.1	-	3	1367	c.655C>T	c.(655-657)Cct>Tct	p.P219S	NRIP1_ENST00000400199.1_Missense_Mutation_p.P219S|NRIP1_ENST00000318948.4_Missense_Mutation_p.P219S			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	219	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		ACATGATGAGGAGACTCTGCA	0.403000													32	111					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347430	48347430	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:48347430C>T	ENST00000319856.4	+	1	959	c.938C>T	c.(937-939)aCc>aTc	p.T313I		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						CTCATTTATACCCTGAGAAAT	0.323000													14	60					0	0	1	0	0
SLC25A42	284439	broad.mit.edu	37	19	19217149	19217149	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19217149C>T	ENST00000318596.7	+	6	603	c.452C>T	c.(451-453)cCc>cTc	p.P151L	SLC25A42_ENST00000600275.1_3'UTR	NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	151					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			CTGACCTACCCCCTGGACCTG	0.657000													19	53					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7457122	7457122	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7457122G>A	ENST00000399422.4	+	1	243	c.195G>A	c.(193-195)aaG>aaA	p.K65K		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	65					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						GGTCCCAAAAGGAGAAGGTAT	0.453000													8	55					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11059542	11059542	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11059542C>T	ENST00000287766.4	+	4	673	c.252C>T	c.(250-252)atC>atT	p.I84I	SLC6A1_ENST00000536032.1_Intron|SLC6A1_ENST00000462473.1_3'UTR|SLC6A1-AS1_ENST00000414969.2_RNA	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	84					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCTTCCTGATCCCCTATTTCC	0.602000													19	77					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147929808	147929808	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:147929808C>T	ENST00000360693.3	-	3	182	c.44G>A	c.(43-45)gGg>gAg	p.G15E	HTR4_ENST00000521530.1_Missense_Mutation_p.G15E|HTR4_ENST00000520514.1_Missense_Mutation_p.G15E|HTR4_ENST00000362016.2_Missense_Mutation_p.G15E|HTR4_ENST00000521735.1_Missense_Mutation_p.G15E|HTR4_ENST00000354217.2_Missense_Mutation_p.G15E|HTR4_ENST00000314512.6_Missense_Mutation_p.G15E|HTR4_ENST00000519495.1_5'UTR|HTR4_ENST00000517929.1_Missense_Mutation_p.G15E|HTR4_ENST00000377888.3_Missense_Mutation_p.G15E	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	15					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	CTCCACTGACCCGAAACCCTC	0.498000													19	59					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55839201	55839201	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:55839201C>T	ENST00000302000.6	-	3	374	c.280G>A	c.(280-282)Ggt>Agt	p.G94S	PYGO1_ENST00000563719.1_Missense_Mutation_p.G94S	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	94	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		CCAGGATAACCAGGGCCAAGA	0.443000													32	136					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88379651	88379651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:88379651C>T	ENST00000298699.2	-	11	1282	c.1102G>A	c.(1102-1104)Gaa>Aaa	p.E368K	C12orf50_ENST00000550553.1_Missense_Mutation_p.E329K	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	368										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						GGTTTGGGTTCCCTGTTAGCA	0.498000													30	98					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14766127	14766127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:14766127C>T	ENST00000261170.3	-	27	3282	c.3146G>A	c.(3145-3147)cGg>cAg	p.R1049Q	RP11-695J4.2_ENST00000545424.1_RNA|RP11-695J4.2_ENST00000542401.1_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	1049					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity	p.R1049L(1)		breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						GCTGGCTACCCGTCTGGGTTT	0.428000													69	256					0	0	1	0	0
AES	166	broad.mit.edu	37	19	3055716	3055716	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3055716G>A	ENST00000221561.8	-	5	623	c.444C>T	c.(442-444)atC>atT	p.I148I	AES_ENST00000586839.1_Silent_p.I25I|AES_ENST00000327141.4_Silent_p.I81I|AES_ENST00000592330.1_Intron	NM_198969.1	NP_945320.1	Q08117	AES_HUMAN	amino-terminal enhancer of split	81	Gly/Pro-rich (GP domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			lung(8)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTTTTGACGATCTCAGCCT	0.662000													31	88					0	0	1	0	0
AHSP	51327	broad.mit.edu	37	16	31539891	31539891	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31539891G>A	ENST00000302312.4	+	3	291	c.188G>A	c.(187-189)cGa>cAa	p.R63Q	AHSP_ENST00000569954.1_3'UTR	NM_016633.2	NP_057717.1	Q9NZD4	AHSP_HUMAN	alpha hemoglobin stabilizing protein	63					hemoglobin metabolic process|hemopoiesis|protein folding|protein stabilization	hemoglobin complex	hemoglobin binding|unfolded protein binding			lung(2)	2						CCCCAAGAGCGAGACAAGGCT	0.547000													28	41					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178594	65178594	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:65178594C>T	ENST00000310045.7	-	2	4755	c.3282G>A	c.(3280-3282)ttG>ttA	p.L1094L	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1084						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				ATTCTTTCCTCAATGGTTCAT	0.368000													6	50					0	0	1	0	0
LPO	4025	broad.mit.edu	37	17	56324854	56324854	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56324854G>A	ENST00000262290.4	+	4	496	c.180G>A	c.(178-180)atG>atA	p.M60I	LPO_ENST00000582328.1_Intron|LPO_ENST00000543544.1_Start_Codon_SNP_p.M1I|LPO_ENST00000421678.2_Intron	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	60					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						AGACCGCCATGAGCTCTGAGA	0.632000													18	53					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88886058	88886058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:88886058C>T	ENST00000319675.3	-	1	238	c.142G>A	c.(142-144)Gag>Aag	p.E48K		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	48										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						ACACGCAGCTCGCGAGCTATA	0.502000													28	78					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179456933	179456933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179456933C>T	ENST00000589042.1	-	302	59922	c.59698G>A	c.(59698-59700)Gaa>Aaa	p.E19900K	TTN_ENST00000342992.6_Missense_Mutation_p.E17332K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E10835K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E11027K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E10960K|TTN_ENST00000591111.1_Missense_Mutation_p.E18259K|TTN-AS1_ENST00000589234.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18259	Ig-like 110.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGTGGTTCTTTCCAAGTA	0.408000													11	19					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130285592	130285592	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:130285592C>T	ENST00000358511.6	+	4	1360	c.1329C>T	c.(1327-1329)ggC>ggT	p.G443G	COL6A6_ENST00000453409.2_Silent_p.G443G	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	443	Nonhelical region.|VWFA 3.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TTATCGATGGCTCAGGGAGCA	0.478000													9	43					0	0	1	0	0
PRKAB2	5565	broad.mit.edu	37	1	146634146	146634146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:146634146G>A	ENST00000254101.3	-	6	683	c.545C>T	c.(544-546)tCc>tTc	p.S182F	PRKAB2_ENST00000425272.2_Missense_Mutation_p.S100F	NM_005399.3	NP_005390.1	O43741	AAKB2_HUMAN	protein kinase, AMP-activated, beta 2 non-catalytic subunit	182					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				NS(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	GGGTGAGCTGGAAAGGTCTGA	0.393000													7	37					0	0	1	0	0
PODXL	5420	broad.mit.edu	37	7	131189133	131189133	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:131189133C>T	ENST00000541194.1	-	9	1877	c.1620G>A	c.(1618-1620)tgG>tgA	p.W540*	PODXL_ENST00000378555.3_Nonsense_Mutation_p.W538*|PODXL_ENST00000322985.9_Nonsense_Mutation_p.W506*|PODXL_ENST00000537928.1_Nonsense_Mutation_p.W506*	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	538					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					GAGGGACGATCCAGCTGTCCC	0.582000													23	94					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104778670	104778670	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:104778670G>A	ENST00000406091.3	+	3	603	c.603G>A	c.(601-603)gtG>gtA	p.V201V		NM_001100117.2	NP_001093587.1	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	232					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TACCTGCAGTGGAGAAAAGTC	0.473000										HNSCC(12;0.0054)			14	61					0	0	1	0	0
TRAV12-1	28674	broad.mit.edu	37	14	22309848	22309848	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22309848G>A	ENST00000390433.1	+	0	232																											CAGTGGTAATGAAGATGGAAG	0.463000													31	99					0	0	1	0	0
URM1	81605	broad.mit.edu	37	9	131140306	131140306	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131140306C>T	ENST00000372847.1	+	2	78	c.68C>T	c.(67-69)tCc>tTc	p.S23F	URM1_ENST00000372853.4_Intron|URM1_ENST00000452446.1_Intron|URM1_ENST00000372850.1_Intron			Q9BTM9	URM1_HUMAN	ubiquitin related modifier 1	0					tRNA thio-modification|tRNA wobble uridine modification		protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)	5						CTCTGGTCCTCCTTTGCAGAG	0.502000													19	55					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163693182	163693182	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163693182C>T	ENST00000332142.5	-	2	271	c.172G>A	c.(172-174)Gat>Aat	p.D58N	KCNH7_ENST00000328032.4_Missense_Mutation_p.D58N	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	58	PAS.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGCATGACATCTGGCCTGGAG	0.468000													34	51					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32259443	32259443	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:32259443C>T	ENST00000360482.2	-	12	2568	c.2439G>A	c.(2437-2439)ggG>ggA	p.G813G	SPOCD1_ENST00000257100.3_Silent_p.G306G|SPOCD1_ENST00000373648.2_3'UTR|SPOCD1_ENST00000533231.1_Silent_p.G813G	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	813					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		AGATATTGTCCCCGCAGCTCT	0.577000													55	185					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40411717	40411717	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40411717C>T	ENST00000221347.6	-	7	3918	c.3911G>A	c.(3910-3912)cGa>cAa	p.R1304Q		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1304	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CACACTGACTCGCCCATTACC	0.627000													55	114					0	0	1	0	0
SPDYE4	388333	broad.mit.edu	37	17	8656701	8656701	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:8656701G>A	ENST00000328794.6	-	5	768	c.592C>T	c.(592-594)Cga>Tga	p.R198*		NM_001128076.1	NP_001121548.1	A6NLX3	SPDE4_HUMAN	speedy/RINGO cell cycle regulator family member E4	198										breast(1)|endometrium(2)|kidney(1)	4						AGCTGGTATCGAAGCTTATGG	0.587000													3	7					0	0	1	0	0
PGF	5228	broad.mit.edu	37	14	75416173	75416173	+	Missense_Mutation	SNP	C	C	T	rs143175863		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75416173C>T	ENST00000555567.1	-	3	743	c.202G>A	c.(202-204)Gag>Aag	p.E68K	PGF_ENST00000553716.1_Missense_Mutation_p.E68K|PGF_ENST00000238607.6_Missense_Mutation_p.E67K|PGF_ENST00000405431.2_Missense_Mutation_p.E68K	NM_002632.5	NP_002623.2	P49763	PLGF_HUMAN	placental growth factor	68					angiogenesis|cell differentiation|cell-cell signaling|positive regulation of cell division|positive regulation of cell proliferation|vascular endothelial growth factor receptor signaling pathway	extracellular region|membrane	growth factor activity|heparin binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(234;0.00668)		TGCTCCACCTCGCTGGGGTAC	0.652000													7	20					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153217341	153217341	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:153217341G>A	ENST00000310441.7	-	20	6177	c.5211C>T	c.(5209-5211)gcC>gcT	p.A1737A	HCFC1_ENST00000354233.3_Silent_p.A1668A|HCFC1_ENST00000369984.4_Silent_p.A1782A	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	1737					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGACCGTGCCGGCCAGCTCAT	0.657000													22	7					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81373758	81373758	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81373758C>T	ENST00000398636.3	+	6	774	c.636C>T	c.(634-636)taC>taT	p.Y212Y	SFTPA1_ENST00000372313.5_Silent_p.Y153Y|SFTPA1_ENST00000419470.2_Silent_p.Y227Y|SFTPA1_ENST00000428376.2_Silent_p.Y212Y|SFTPA1_ENST00000372308.3_Silent_p.Y212Y	NM_001164644.1|NM_001164646.1|NM_005411.4	NP_001158116.1|NP_001158118.1|NP_005402.3	Q8IWL2	SFTA1_HUMAN	surfactant protein A1	212	C-type lectin.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			CCAACTGGTACCGAGGGGAGC	0.557000													95	191					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51387787	51387787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51387787C>T	ENST00000266037.9	+	40	4094	c.4071C>T	c.(4069-4071)gtC>gtT	p.V1357V		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1357	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCTTTCGGGTCGGCTTCTATG	0.438000													49	115					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91498068	91498068	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:91498068G>A	ENST00000266718.4	-	3	1345	c.891C>T	c.(889-891)atC>atT	p.I297I	LUM_ENST00000548071.1_5'UTR	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	297					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						ATGGCCCCAGGATCTTGCAGA	0.368000													17	50					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474636	140474636	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140474636T>G	ENST00000194155.4	+	1	410	c.262T>G	c.(262-264)Tta>Gta	p.L88V		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		88	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGATTTGTTGTTAAATGAGAA	0.512000													43	93					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2963962	2963962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:2963962G>A	ENST00000396946.4	-	15	2248	c.1845C>T	c.(1843-1845)tcC>tcT	p.S615S		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	615					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		AGGAGTGGATGGAGGAGGGTC	0.612000			Mis		DLBCL								32	59					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21036173	21036173	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:21036173G>A	ENST00000247986.2	-	4	939	c.629C>T	c.(628-630)tCg>tTg	p.S210L	KIF17_ENST00000400463.3_Missense_Mutation_p.S210L|KIF17_ENST00000375044.1_Missense_Mutation_p.S110L			Q9P2E2	KIF17_HUMAN	kinesin family member 17	210	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GATGGAGTGCGAGCGTGAGGA	0.592000													11	95					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149073664	149073664	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:149073664C>T	ENST00000355292.3	-	6	2840	c.2478G>A	c.(2476-2478)acG>acA	p.T826T	NR3C2_ENST00000512865.1_Silent_p.T705T|NR3C2_ENST00000344721.4_Silent_p.T822T|NR3C2_ENST00000511528.1_Silent_p.T826T|RP11-76G10.1_ENST00000514843.1_RNA|NR3C2_ENST00000503313.1_5'UTR|NR3C2_ENST00000358102.3_Silent_p.T822T|NR3C2_ENST00000342437.4_Intron			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	822	Steroid-binding.		F -> Y (in dbSNP:rs13306592).		regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding	p.T822T(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ATTGGCTGTTCGTATGTTTGT	0.363000													27	73					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11285177	11285177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:11285177G>A	ENST00000432929.2	-	9	2424	c.2064C>T	c.(2062-2064)ttC>ttT	p.F688F	KANK2_ENST00000355150.5_Silent_p.F680F|KANK2_ENST00000586659.1_Silent_p.F680F|KANK2_ENST00000589894.1_Silent_p.F680F|KANK2_ENST00000589359.1_Silent_p.F688F	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	680										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCACCACGGGGAAGTTGGCAT	0.642000													4	19					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122664264	122664264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:122664264C>T	ENST00000263461.6	+	25	3380	c.3134C>T	c.(3133-3135)cCc>cTc	p.P1045L	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	1045						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						TCGTCAGGCCCCTCTCAGAGC	0.443000													39	81					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114275979	114275979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:114275979C>T	ENST00000357077.4	+	38	6258	c.6205C>T	c.(6205-6207)Cgt>Tgt	p.R2069C	ANK2_ENST00000264366.6_Missense_Mutation_p.R2036C|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2036					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGAGGAGTTCGTGTTTCCTC	0.468000													76	50					0	0	1	0	0
STAC2	342667	broad.mit.edu	37	17	37374290	37374290	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:37374290G>A	ENST00000333461.5	-	2	596	c.227C>T	c.(226-228)cCt>cTt	p.P76L		NM_198993.3	NP_945344.1	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	76	Pro-rich.				intracellular signal transduction		metal ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(2)	17						TGGGGAGGGAGGGGGCAGTGG	0.667000													4	7					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37916554	37916554	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:37916554G>A	ENST00000199447.4	+	12	1311	c.939G>A	c.(937-939)atG>atA	p.M313I	EPDR1_ENST00000476620.1_Intron|NME8_ENST00000440017.1_Missense_Mutation_p.M313I	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	313					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										TGAAAAGCATGAAATTAGAAA	0.343000													16	58					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231189	21231189	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21231189C>T	ENST00000233242.1	-	26	8678	c.8551G>A	c.(8551-8553)Gag>Aag	p.E2851K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2851					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATTTTCCCTCAATAGCATTT	0.413000													58	220					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10222127	10222127	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10222127C>T	ENST00000418404.3	-	26	3881	c.3718G>A	c.(3718-3720)Gag>Aag	p.E1240K	MYH13_ENST00000570743.1_Missense_Mutation_p.E1240K|MYH13_ENST00000252172.4_Missense_Mutation_p.E1240K			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1240					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.E1240K(2)		breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GAGAGAGCCTCGATGTTGCTG	0.567000													44	46					0	0	1	0	0
CLU	1191	broad.mit.edu	37	8	27463978	27463978	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27463978C>T	ENST00000316403.10	-	4	715	c.310G>A	c.(310-312)Gag>Aag	p.E104K	CLU_ENST00000405140.3_Missense_Mutation_p.E104K|CLU_ENST00000523500.1_Missense_Mutation_p.E104K|CLU_ENST00000560366.1_Missense_Mutation_p.E156K|CLU_ENST00000546343.1_Missense_Mutation_p.E115K			P10909	CLUS_HUMAN	clusterin	104					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		ATCATGGTCTCATTGCACACT	0.552000													51	145					0	0	1	0	0
NBR2	10230	broad.mit.edu	37	17	41291969	41291969	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:41291969C>T	ENST00000460115.1	+	0	627					NR_003108.1																						ttcctaaatcccttggaattt	0.413000													4	2					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56271342	56271342	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56271342G>A	ENST00000225371.5	+	5	593	c.483G>A	c.(481-483)ggG>ggA	p.G161G		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	161					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding	p.G161G(1)		breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						CCTTGCTAGGGGCCTCCAACC	0.667000													15	40					0	0	1	0	0
ICAM4	3386	broad.mit.edu	37	19	10397994	10397994	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10397994C>T	ENST00000393717.2	+	1	315	c.306C>T	c.(304-306)ctC>ctT	p.L102L	ICAM4_ENST00000380770.3_Silent_p.L102L|ICAM4_ENST00000340992.4_Silent_p.L102L|CTD-2369P2.8_ENST00000589379.1_RNA	NM_022377.3	NP_071772.1	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	102	Ig-like C2-type 1.				cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			breast(1)|large_intestine(3)|lung(2)|pancreas(1)	7			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			ACCAGCTGCTCGACGTGAGGG	0.662000													11	19					0	0	1	0	0
ABAT	18	broad.mit.edu	37	16	8862729	8862729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:8862729C>T	ENST00000396600.2	+	11	1653	c.715C>T	c.(715-717)Cct>Tct	p.P239S	ABAT_ENST00000567812.1_Missense_Mutation_p.P254S|ABAT_ENST00000569156.1_Missense_Mutation_p.P239S|ABAT_ENST00000425191.2_Missense_Mutation_p.P239S|ABAT_ENST00000268251.8_Missense_Mutation_p.P239S	NM_000663.4	NP_000654.2	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase	239					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	26					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	GATCGACATCCCTTCCTTTGA	0.527000													32	300					0	0	1	0	0
CLDN14	23562	broad.mit.edu	37	21	37833570	37833570	+	Missense_Mutation	SNP	C	C	T	rs146755542	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:37833570C>T	ENST00000399137.1	-	3	1290	c.424G>A	c.(424-426)Gac>Aac	p.D142N	CLDN14_ENST00000399139.1_Missense_Mutation_p.D142N|CLDN14_ENST00000399135.1_Missense_Mutation_p.D142N|AP000695.6_ENST00000429588.1_RNA|CLDN14_ENST00000342108.2_Missense_Mutation_p.D142N|CLDN14_ENST00000399136.1_Missense_Mutation_p.D142N|AP000695.4_ENST00000428667.1_RNA	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	142					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						TGCACCACGTCGTTGGTGGTC	0.627000													27	83					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102302440	102302440	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:102302440C>T	ENST00000370103.4	-	2	424	c.211G>A	c.(211-213)Gaa>Aaa	p.E71K	OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000338858.5_Missense_Mutation_p.E91K|OLFM3_ENST00000536598.1_5'UTR|OLFM3_ENST00000359814.3_Missense_Mutation_p.E91K	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	91						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CCTACCTTTTCCAGTAGTTGG	0.448000													53	101					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810959	65810959	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65810959G>A	ENST00000312006.4	-	3	596	c.315C>T	c.(313-315)ttC>ttT	p.F105F	GAL3ST3_ENST00000527878.1_Silent_p.F105F	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	105					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GGGGGTAGCAGAACTGGTGCT	0.687000													12	24					0	0	1	0	0
JSRP1	126306	broad.mit.edu	37	19	2252699	2252699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2252699C>T	ENST00000300961.5	-	7	689	c.625G>A	c.(625-627)Gag>Aag	p.E209K	JSRP1_ENST00000586471.1_Missense_Mutation_p.E209K	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	209						sarcoplasmic reticulum membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGTCGTTCTCTGCAGCCTCC	0.706000													28	113					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134627674	134627674	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:134627674C>T	ENST00000368586.5	-	54	7470	c.7370G>A	c.(7369-7371)gGa>gAa	p.G2457E	TTC40_ENST00000263170.5_Missense_Mutation_p.G618E	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	618										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						GTGCTTGCTTCCCAGATGTCC	0.587000													12	39					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688288	60688288	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:60688288C>T	ENST00000335712.6	-	4	1986	c.1759G>A	c.(1759-1761)Gaa>Aaa	p.E587K	BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Missense_Mutation_p.E553K|BCL11A_ENST00000537768.1_Missense_Mutation_p.E256K|BCL11A_ENST00000358510.4_Missense_Mutation_p.E553K|BCL11A_ENST00000356842.4_Missense_Mutation_p.E587K	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	587					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACCGAGTCTTCGTCGCAAGTG	0.672000			T	IGH@	B-CLL								15	26					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44272158	44272158	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:44272158C>T	ENST00000315087.7	-	3	945	c.285G>A	c.(283-285)atG>atA	p.M95I	ST8SIA5_ENST00000590497.1_5'UTR|ST8SIA5_ENST00000538168.1_Missense_Mutation_p.M131I|ST8SIA5_ENST00000536490.1_Missense_Mutation_p.M64I	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	95					glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						CAGAGATGTTCATCGCCCATT	0.507000													21	59					0	0	1	0	0
HNRNPL	3191	broad.mit.edu	37	19	39336578	39336578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39336578G>A	ENST00000221419.5	-	3	905	c.539C>T	c.(538-540)tCc>tTc	p.S180F	HNRNPL_ENST00000600873.1_Missense_Mutation_p.S47F	NM_001533.2	NP_001524.2	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	180					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CCCAGGGCGGGAGATCTTCTG	0.542000													44	109					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34118537	34118537	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:34118537C>T	ENST00000297161.2	+	13	1521	c.1147C>T	c.(1147-1149)Cag>Tag	p.Q383*	BMPER_ENST00000426693.1_Nonsense_Mutation_p.Q383*	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	383	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						ATTTAACTTTCAGGGGACGTG	0.572000													53	137					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760871	20760871	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20760871C>T	ENST00000400451.2	+	5	2062	c.1548C>T	c.(1546-1548)atC>atT	p.I516I	ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Silent_p.I516I|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000405993.1_Silent_p.I484I	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	516					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGTCCCTCATCGTGCACCAGC	0.592000													32	98					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104144428	104144428	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104144428C>T	ENST00000388887.2	+	60	6714	c.6510C>T	c.(6508-6510)ccC>ccT	p.P2170P	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2170					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGCAGCTGCCCATTGACCGCT	0.552000													18	52					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10255195	10255195	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:10255195G>A	ENST00000256458.4	+	6	841	c.751G>A	c.(751-753)Gaa>Aaa	p.E251K		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	251	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						AGGATCAATCGAAAGATTCTT	0.468000													9	102					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5221023	5221023	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:5221023G>A	ENST00000372412.4	-	20	3679	c.3446C>T	c.(3445-3447)cCc>cTc	p.P1149L	PTPRS_ENST00000348075.2_Missense_Mutation_p.P1126L|PTPRS_ENST00000587303.1_Missense_Mutation_p.P1148L|PTPRS_ENST00000588012.1_Missense_Mutation_p.P1126L|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000353284.2_Missense_Mutation_p.P717L|PTPRS_ENST00000262963.6_Missense_Mutation_p.P1144L|PTPRS_ENST00000592099.1_Missense_Mutation_p.P717L|PTPRS_ENST00000357368.4_Missense_Mutation_p.P1148L			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1148					cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GACAGGCACGGGGCTCTGGCC	0.622000													38	99					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55340191	55340191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55340191C>T	ENST00000314634.3	+	1	588	c.588C>T	c.(586-588)ctC>ctT	p.L196L		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				TTAACCTACTCCTGGTTTCCA	0.443000													33	72					0	0	1	0	0
PEX2	5828	broad.mit.edu	37	8	77896041	77896041	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77896041C>T	ENST00000419564.2	-	4	838	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	PEX2_ENST00000357039.4_Missense_Mutation_p.R125Q|PEX2_ENST00000520103.1_Missense_Mutation_p.R125Q|PEX2_ENST00000522527.1_Missense_Mutation_p.R125Q	NM_001172087.1	NP_001165558.1	P28328	PEX2_HUMAN	peroxisomal biogenesis factor 2	125					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	14						ATGATGGTTTCGAAACAAATC	0.363000													35	88					0	0	1	0	0
FAM92A1P2	403315	broad.mit.edu	37	4	183959078	183959078	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183959078G>A	ENST00000502308.1	+	0	261					NR_003612.1																						GAGGATGAATGAAATCAACTC	0.473000													5	8					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233190032	233190032	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233190032G>A	ENST00000258229.8	-	25	4567	c.4333C>T	c.(4333-4335)Cga>Tga	p.R1445*	PCNXL2_ENST00000344698.2_Nonsense_Mutation_p.R97*	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1445						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TCCAGTCCTCGAAGTTGAAAG	0.388000													9	27					0	0	1	0	0
F2RL1	2150	broad.mit.edu	37	5	76128799	76128799	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:76128799C>T	ENST00000296677.4	+	2	573	c.367C>T	c.(367-369)Ctc>Ttc	p.L123F		NM_005242.4	NP_005233.3	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	123					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		GGCTGACCTCCTCTCTGTCAT	0.463000													70	290					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179620142	179620142	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:179620142C>T	ENST00000444136.1	+	12	2191	c.1941C>T	c.(1939-1941)ttC>ttT	p.F647F	TDRD5_ENST00000367614.1_Silent_p.F647F|TDRD5_ENST00000294848.8_Silent_p.F647F	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	647					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						ATGTCTATTTCCATCATGTCT	0.383000													50	123					0	0	1	0	0
SLC36A4	120103	broad.mit.edu	37	11	92881964	92881964	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:92881964G>A	ENST00000326402.4	-	11	1384	c.1254C>T	c.(1252-1254)ttC>ttT	p.F418F	SLC36A4_ENST00000529184.1_Silent_p.F283F	NM_152313.2	NP_689526.2	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 4	418					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	25		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CAGCTCCAACGAAGGAAATCA	0.363000													6	101					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17198952	17198952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:17198952C>T	ENST00000180173.5	-	6	686	c.652G>A	c.(652-654)Gag>Aag	p.E218K	MTMR7_ENST00000523571.1_5'UTR|MTMR7_ENST00000521857.1_Missense_Mutation_p.E218K	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	218	Myotubularin phosphatase.						protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		TGCTCGTCCTCTAGGCACCGG	0.572000													11	38					0	0	1	0	0
SMTNL1	219537	broad.mit.edu	37	11	57313798	57313798	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:57313798G>A	ENST00000457912.1	+	6	1220	c.1220G>A	c.(1219-1221)cGa>cAa	p.R407Q	SMTNL1_ENST00000527972.1_Missense_Mutation_p.R389Q|SMTNL1_ENST00000399154.2_Missense_Mutation_p.R352Q			E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	389										endometrium(2)|large_intestine(1)|lung(4)|ovary(1)	8						GAGTGGTGCCGAGCCATGACA	0.622000													5	16					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104596855	104596855	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104596855C>T	ENST00000369887.3	-	1	435	c.264G>A	c.(262-264)aaG>aaA	p.K88K	CYP17A1_ENST00000489268.1_5'UTR	NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	88					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	CCTTGCCCTTCTTAATAAGCA	0.547000													34	81					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240071103	240071103	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:240071103G>A	ENST00000255380.4	+	5	1131	c.352G>A	c.(352-354)Ggg>Agg	p.G118R		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	118					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TCTGATTATCGGGGTCATTTC	0.478000													20	51					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33027990	33027990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:33027990C>T	ENST00000374864.4	+	9	923	c.710C>T	c.(709-711)tCt>tTt	p.S237F	ITCH_ENST00000535650.1_Missense_Mutation_p.S127F|ITCH_ENST00000262650.6_Missense_Mutation_p.S278F	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	278					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						TCTGCCACTTCTGAAAGTGAT	0.358000													10	60					0	0	1	0	0
GPX3	2878	broad.mit.edu	37	5	150407676	150407676	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150407676G>A	ENST00000388825.4	+	5	758	c.666G>A	c.(664-666)ggG>ggA	p.G222G	GPX3_ENST00000517973.1_3'UTR	NM_002084.3	NP_002075.2	P22352	GPX3_HUMAN	glutathione peroxidase 3 (plasma)	222					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding			kidney(1)|large_intestine(3)|lung(1)|skin(1)	6		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CAGCCCTGGGGGTCAAGAGGA	0.562000													3	5					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139653178	139653178	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139653178C>T	ENST00000263552.6	+	10	1003	c.465C>T	c.(463-465)ctC>ctT	p.L155L	TBXAS1_ENST00000425687.1_Silent_p.L87L|TBXAS1_ENST00000416849.2_Silent_p.L201L|TBXAS1_ENST00000411653.1_Silent_p.L154L|TBXAS1_ENST00000414508.2_Silent_p.L155L|TBXAS1_ENST00000458722.1_Silent_p.L200L|TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000336425.5_Silent_p.L154L|TBXAS1_ENST00000436047.2_Silent_p.L155L|TBXAS1_ENST00000448866.1_Silent_p.L154L	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	154					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					TGGTTCCCCTCATCAGCCAAG	0.473000													23	80					0	0	1	0	0
PLAU	5328	broad.mit.edu	37	10	75676148	75676148	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75676148G>A	ENST00000446342.1	+	10	1552	c.1068_splice	c.e10-1	p.G357_splice	C10orf55_ENST00000412307.2_Intron|C10orf55_ENST00000409178.1_Intron|PLAU_ENST00000372764.3_Splice_Site_p.G374_splice|PLAU_ENST00000372762.4_Splice_Site_p.G338_splice	NM_001145031.1	NP_001138503.1	P00749	UROK_HUMAN	plasminogen activator, urokinase	374	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	GCGTCACAGGGAGACTCAGGG	0.557000													5	20					0	0	1	0	0
HARS2	23438	broad.mit.edu	37	5	140075096	140075096	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140075096C>T	ENST00000230771.3	+	5	626	c.403C>T	c.(403-405)Ccc>Tcc	p.P135S	HARS2_ENST00000437649.2_Intron|HARS2_ENST00000435019.2_Missense_Mutation_p.P95S|HARS2_ENST00000448069.2_Intron|HARS2_ENST00000432671.2_Intron|HARS2_ENST00000508522.1_Missense_Mutation_p.P110S|HARS2_ENST00000502303.1_3'UTR	NM_012208.2	NP_036340.1	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2, mitochondrial	135					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity			NS(1)|endometrium(3)|large_intestine(5)|lung(10)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTGAGGTTCCCTTTGCTCG	0.488000													61	194					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55110701	55110701	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55110701G>A	ENST00000453777.1	+	6	832	c.661_splice	c.e6-1	p.G221_splice	LILRA1_ENST00000251372.3_Splice_Site_p.G421_splice|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	221	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		TGATTCTCAGGAGCAGCTGAG	0.448000													15	47					0	0	1	0	0
SPAG1	6674	broad.mit.edu	37	8	101206358	101206358	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:101206358G>A	ENST00000388798.2	+	10	1149	c.958G>A	c.(958-960)Gaa>Aaa	p.E320K	SPAG1_ENST00000520643.1_Missense_Mutation_p.E320K|SPAG1_ENST00000520508.1_Missense_Mutation_p.E320K|SPAG1_ENST00000251809.3_Missense_Mutation_p.E320K	NM_003114.4	NP_003105.2	Q07617	SPAG1_HUMAN	sperm associated antigen 1	320					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		GTCAGAGGTTGAAAGAGATCT	0.313000													11	52					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158151263	158151263	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158151263C>T	ENST00000368171.3	+	3	579	c.80C>T	c.(79-81)cCc>cTc	p.P27L		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	27					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					AGGCTTTTCCCCCTCCGCTGC	0.592000													141	368					0	0	1	0	0
ADAM20	8748	broad.mit.edu	37	14	70991597	70991597	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:70991597G>A	ENST00000256389.3	-	2	272	c.28C>T	c.(28-30)Ccc>Tcc	p.P10S	RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003814.4	NP_003805.3	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20	0					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GGGATCTGGGGATCTGTGTCC	0.532000													45	100					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319497	21319497	+	Silent	SNP	C	C	T	rs139358757	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:21319497C>T	ENST00000583088.1	+	3	1738	c.843C>T	c.(841-843)ttC>ttT	p.F281F	KCNJ12_ENST00000331718.5_Silent_p.F281F	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.F281F(1)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GCCCGCTCTTCGGCATCAGCC	0.607000										Prostate(3;0.18)			10	66					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92488054	92488054	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:92488054G>A	ENST00000267622.4	-	4	807	c.434C>T	c.(433-435)tCa>tTa	p.S145L		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	145					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		ATAAGCGAATGAAGATGATGC	0.458000			T	PDGFRB	AML								21	41					0	0	1	0	0
RP11-483E23.2	0	broad.mit.edu	37	15	28600112	28600112	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:28600112C>T	ENST00000568624.1	-	0	382																											CTCTAGCTCCCTCCTTAGGGC	0.507000													8	60					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45798380	45798380	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:45798380G>A	ENST00000357450.4	-	5	686	c.687C>T	c.(685-687)taC>taT	p.Y229Y	SMC1B_ENST00000404354.3_Silent_p.Y229Y	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	229					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TCTCATTATGGTATAGTTGAA	0.358000													49	111					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103057146	103057146	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103057146G>A	ENST00000375735.2	+	42	6953	c.6809G>A	c.(6808-6810)cGa>cAa	p.R2270Q	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.R2270Q	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2270	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GACATGCAACGAGGTCTAGAT	0.408000													19	51					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173569281	173569281	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173569281C>T	ENST00000367714.3	-	3	625	c.203G>A	c.(202-204)gGa>gAa	p.G68E	SLC9C2_ENST00000536496.1_Intron|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	68					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										GGCCATGTGTCCTATCACGAA	0.348000													9	74					0	0	1	0	0
LRRC25	126364	broad.mit.edu	37	19	18507007	18507007	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18507007C>T	ENST00000339007.3	-	1	1420	c.767G>A	c.(766-768)tGg>tAg	p.W256*	LRRC25_ENST00000595840.1_Nonsense_Mutation_p.W256*	NM_145256.2	NP_660299.2	Q8N386	LRC25_HUMAN	leucine rich repeat containing 25	256						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|skin(1)	8						TTGTTCATCCCACTGGTGCTC	0.597000													20	83					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531185	140531185	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140531185C>T	ENST00000231136.1	+	1	1347	c.1347C>T	c.(1345-1347)ttC>ttT	p.F449F	PCDHB6_ENST00000543635.1_Silent_p.F313F	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		449	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCCGCCTTCACCCAAACCT	0.582000													72	176					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107360822	107360822	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:107360822C>T	ENST00000374779.2	-	1	966	c.873G>A	c.(871-873)atG>atA	p.M291I		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						TTAAAGGATTCATCATGGGAG	0.373000													6	82					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887095	9887095	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:9887095G>A	ENST00000306084.6	+	2	818	c.619G>A	c.(619-621)Ggt>Agt	p.G207S	TXNDC2_ENST00000357775.4_Missense_Mutation_p.G140S|TXNDC2_ENST00000536353.2_Intron	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	207	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GCCCAAAGAGGGTGACATCCC	0.567000													55	170					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36677252	36677252	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:36677252G>A	ENST00000265113.4	+	6	1302	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K	SLC1A3_ENST00000381918.3_Missense_Mutation_p.E276K|CTD-2353F22.1_ENST00000510740.1_RNA	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	276					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TTCTCTTAACGAAGCCATCAT	0.413000													32	62					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10971322	10971322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:10971322C>T	ENST00000298232.7	-	5	402	c.35G>A	c.(34-36)gGa>gAa	p.G12E	TPTE_ENST00000361285.4_Missense_Mutation_p.G12E|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.G12E	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	12					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AATGATGACTCCCGCCAGGTC	0.453000													10	62					0	0	1	0	0
QRICH1	54870	broad.mit.edu	37	3	49094946	49094946	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49094946G>A	ENST00000395443.2	-	3	1159	c.687C>T	c.(685-687)ccC>ccT	p.P229P	QRICH1_ENST00000424300.1_Silent_p.P229P|QRICH1_ENST00000479449.1_Intron|QRICH1_ENST00000357496.2_Silent_p.P229P	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	229	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CCCCTTCCCGGGGTGAGCCCT	0.632000													24	45					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759655	6759655	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:6759655G>A	ENST00000378827.4	+	3	2329	c.1110G>A	c.(1108-1110)tcG>tcA	p.S370S		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	370					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	GTGCTATCTCGATGCTGTACC	0.428000													15	50					0	0	1	0	0
STK40	83931	broad.mit.edu	37	1	36823848	36823848	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:36823848G>A	ENST00000359297.2	-	3	341	c.334C>T	c.(334-336)Ctc>Ttc	p.L112F	STK40_ENST00000373130.3_Missense_Mutation_p.L117F|STK40_ENST00000373132.3_Missense_Mutation_p.L112F|STK40_ENST00000373129.3_Missense_Mutation_p.L112F|STK40_ENST00000482458.1_5'UTR			Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	112	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)	13		Myeloproliferative disorder(586;0.0393)				ACCTGGAAGAGGCCGTGGTGG	0.647000													25	27					0	0	1	0	0
WDR16	146845	broad.mit.edu	37	17	9515755	9515755	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:9515755G>A	ENST00000352665.5	+	8	1053	c.984G>A	c.(982-984)gcG>gcA	p.A328A	WDR16_ENST00000299764.5_Silent_p.A338A|WDR16_ENST00000396219.3_Silent_p.A260A	NM_145054.4	NP_659491.4	Q8N1V2	WDR16_HUMAN	WD repeat domain 16	328						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31						CGCTCATAGCGACTTGTCACT	0.433000													22	31					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51901192	51901192	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:51901192C>T	ENST00000268919.4	+	1	954	c.798C>T	c.(796-798)ttC>ttT	p.F266F		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	266	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CCTTCTGCTTCGACCATGCCT	0.557000													5	69					0	0	1	0	0
PARVA	55742	broad.mit.edu	37	11	12539227	12539227	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12539227T>C	ENST00000334956.8	+	11	1401	c.1058T>C	c.(1057-1059)tTc>tCc	p.F353S	PARVA_ENST00000550549.1_Missense_Mutation_p.F313S|PARVA_ENST00000539723.1_Missense_Mutation_p.F313S	NM_018222.4	NP_060692.2	Q9NVD7	PARVA_HUMAN	parvin, alpha	313	CH 2.				cell adhesion|cell junction assembly|cilium morphogenesis	actin cytoskeleton|cytosol|focal adhesion	actin binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)	11				Epithelial(150;0.00624)		CTGCACAGCTTCTTCCTGACC	0.597000													3	13					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940488	144940488	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144940488C>T	ENST00000525985.1	-	2	7005	c.6934G>A	c.(6934-6936)Gac>Aac	p.D2312N				P58107	EPIPL_HUMAN	epiplakin 1	2312						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTGTAGGGGTCGGTGTAGCCG	0.701000													14	300					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139428696	139428696	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:139428696C>T	ENST00000272641.3	-	2	697	c.591G>A	c.(589-591)gcG>gcA	p.A197A		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	197	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		CGGTCTTTTTCGCCCGATCTG	0.488000													13	25					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55174690	55174690	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55174690C>T	ENST00000414150.2	+	23	3949	c.3671C>T	c.(3670-3672)tCc>tTc	p.S1224F	MROH7_ENST00000454855.2_Missense_Mutation_p.S742F|MROH7_ENST00000421030.2_Missense_Mutation_p.S1224F|MROH7_ENST00000409996.1_Missense_Mutation_p.S792F					maestro heat-like repeat family member 7																		GCTCAAGGGTCCCTGGTCCCC	0.522000													29	93					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767332	77767332	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:77767332G>A	ENST00000521891.2	+	10	8623	c.8175G>A	c.(8173-8175)caG>caA	p.Q2725Q	ZFHX4_ENST00000050961.6_Silent_p.Q2680Q|ZFHX4_ENST00000455469.2_Silent_p.Q2680Q|ZFHX4_ENST00000518282.1_Silent_p.Q2699Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2680						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAGCCCACAGAAATACATCT	0.428000										HNSCC(33;0.089)			5	29					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6932137	6932137	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:6932137C>T	ENST00000383032.1	+	8	1051	c.404C>T	c.(403-405)cCa>cTa	p.P135L	TBL1Y_ENST00000346432.3_Missense_Mutation_p.P135L|TBL1Y_ENST00000355162.2_Missense_Mutation_p.P135L	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	135					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						CAAAATCCTCCAAAGAACCGA	0.547000													23	14					0	0	1	0	0
RND3	390	broad.mit.edu	37	2	151328151	151328151	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:151328151G>A	ENST00000375734.2	-	4	722	c.473C>T	c.(472-474)tCc>tTc	p.S158F	RND3_ENST00000472416.1_Intron|RND3_ENST00000409557.1_Missense_Mutation_p.S29F|RND3_ENST00000263895.4_Missense_Mutation_p.S158F	NM_001254738.1	NP_001241667.1	P61587	RND3_HUMAN	Rho family GTPase 3	158					actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.106)		CTGGTCATAGGACACTGGCGT	0.408000													11	168					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49295430	49295430	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:49295430C>T	ENST00000406846.2	-	2	272		c.e2-1		FSHR_ENST00000304421.4_Splice_Site|FSHR_ENST00000346173.3_Splice_Site	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor						female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GACAAACCTCCTGCAAAGAGA	0.383000									Gonadal Dysgenesis, 46 XX				11	104					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59971154	59971154	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:59971154G>A	ENST00000444766.3	-	13	1769	c.1694C>T	c.(1693-1695)tCc>tTc	p.S565F	INTS2_ENST00000251334.6_Missense_Mutation_p.S557F	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	565					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						CTTGGTAAAGGAACGGCTCCT	0.378000													6	12					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32811801	32811801	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:32811801C>T	ENST00000380250.3	+	44	6592	c.6096C>T	c.(6094-6096)tcC>tcT	p.S2032S		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2032					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CGGACCCATCCCACATAAACC	0.498000													7	27					0	0	1	0	0
PIGN	23556	broad.mit.edu	37	18	59770101	59770101	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:59770101G>A	ENST00000357637.5	-	21	2309	c.1894C>T	c.(1894-1896)Ctg>Ttg	p.L632L	PIGN_ENST00000400334.3_Silent_p.L632L	NM_176787.4	NP_789744.1	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class N	632					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(73;0.187)				ACAACACACAGGGATAACAGA	0.333000													4	12					0	0	1	0	0
GPBP1	65056	broad.mit.edu	37	5	56527007	56527007	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:56527007C>T	ENST00000424459.3	+	5	1544	c.270C>T	c.(268-270)taC>taT	p.Y90Y	GPBP1_ENST00000538707.1_Silent_p.Y97Y|GPBP1_ENST00000264779.6_Silent_p.Y97Y|GPBP1_ENST00000511209.1_Silent_p.Y97Y|GPBP1_ENST00000514387.2_5'UTR|GPBP1_ENST00000454432.2_Silent_p.Y90Y|GPBP1_ENST00000506184.2_Silent_p.Y90Y	NM_022913.3	NP_075064.1	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	19		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		GAGGTGGATACCATGGTGGAA	0.398000													6	86					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66190265	66190265	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:66190265G>A	ENST00000311034.2	+	4	727	c.551G>A	c.(550-552)gGa>gAa	p.G184E		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	184					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						TACTGGGCAGGAAATCCCGTG	0.622000													41	92					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103908622	103908622	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103908622C>T	ENST00000278070.2	+	12	4705	c.4666C>T	c.(4666-4668)Cga>Tga	p.R1556*	PPRC1_ENST00000489648.1_3'UTR|PPRC1_ENST00000370012.1_Nonsense_Mutation_p.R523*|PPRC1_ENST00000413464.2_Nonsense_Mutation_p.R1292*	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1556	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CCGCATGACTCGATCAGAGCT	0.488000													23	42					0	0	1	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17369021	17369021	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:17369021G>A	ENST00000377602.4	-	6	701	c.627C>T	c.(625-627)ttC>ttT	p.F209F		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	209					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						ACCTAAAAACGAAGTCGGATT	0.383000													30	51					0	0	1	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228679	57228679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57228679C>T	ENST00000396721.2	-	2	358	c.228G>A	c.(226-228)ggG>ggA	p.G76G	SDR16C5_ENST00000522671.1_Silent_p.G76G|SDR16C5_ENST00000303749.3_Silent_p.G76G			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	76					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						TTTCCTCATTCCCCTCCTTAT	0.522000													17	112					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29455197	29455197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29455197C>T	ENST00000389048.3	-	15	3511	c.2605G>A	c.(2605-2607)Ggg>Agg	p.G869R	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	869	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCGTTTAGCCCTAGAACCGAG	0.622000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				30	82					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70933493	70933493	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:70933493C>T	ENST00000264436.3	-	3	492	c.48G>A	c.(46-48)caG>caA	p.Q16Q	ADD2_ENST00000407644.2_Silent_p.Q16Q|ADD2_ENST00000430656.1_Silent_p.Q32Q|ADD2_ENST00000355733.3_Silent_p.Q16Q|ADD2_ENST00000413157.2_Silent_p.Q16Q	NM_001617.3	NP_001608.1	P35612	ADDB_HUMAN	adducin 2 (beta)	16					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						AAGGCTGCCCCTGCGGGGGCG	0.642000													30	76					0	0	1	0	0
CNTFR	1271	broad.mit.edu	37	9	34552812	34552812	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34552812G>A	ENST00000378980.3	-	8	1102	c.809C>T	c.(808-810)gCc>gTc	p.A270V	CNTFR_ENST00000351266.4_Missense_Mutation_p.A270V	NM_001207011.1|NM_147164.2	NP_001193940.1|NP_671693.1	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	270	Fibronectin type-III 2.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(4)|skin(1)	15	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		CCCGGCGTAGGCATCTGTGAT	0.622000													22	126					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7845399	7845399	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:7845399C>T	ENST00000283147.6	+	2	850	c.691C>T	c.(691-693)Cgt>Tgt	p.R231C		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	231					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					GTTCTCCCCTCGTCAGCGACA	0.468000													33	105					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233372591	233372591	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:233372591C>T	ENST00000258229.8	-	9	2592	c.2358_splice	c.e9+1	p.R786_splice	PCNXL2_ENST00000430153.1_Splice_Site_p.R85_splice	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	786						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				ATGTACGTACCCGTGGGGTTT	0.507000													38	160					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169432901	169432901	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:169432901G>A	ENST00000261509.6	+	2	457	c.246G>A	c.(244-246)aaG>aaA	p.K82K	PALLD_ENST00000333488.4_5'UTR|PALLD_ENST00000335742.7_5'UTR|PALLD_ENST00000505667.1_Silent_p.K82K	NM_001166108.1|NM_016081.3	NP_001159580.1|NP_057165.3	Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	82					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CTTCCCATAAGGAGACCAAAT	0.483000									Pancreatic Cancer, Familial Clustering of				8	36					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51673920	51673920	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:51673920C>T	ENST00000409535.1	+	13	2261	c.2136C>T	c.(2134-2136)taC>taT	p.Y712Y	RAD54L2_ENST00000296477.3_Silent_p.Y406Y	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	712						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TGACTAATTACCAGACTGGAG	0.458000													8	24					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76757169	76757169	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:76757169C>T	ENST00000536229.3	+	3	3844	c.3135C>T	c.(3133-3135)ctC>ctT	p.L1045L	SALL3_ENST00000537592.2_Silent_p.L1250L|SALL3_ENST00000575389.2_Silent_p.L1178L			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCAGCGCCCTCCCCCCTCTGG	0.622000													54	150					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6087196	6087196	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:6087196C>T	ENST00000409021.3	-	4	1234	c.785G>A	c.(784-786)aGa>aAa	p.R262K	JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000410077.2_Missense_Mutation_p.R97K|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.R262K|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.R262K|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.R97K	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	262	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CGGGAGCTCTCTCTTTGGACT	0.627000													19	62					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080214	29080214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29080214G>A	ENST00000377169.1	+	1	547	c.547G>A	c.(547-549)Gaa>Aaa	p.E183K		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						CTTTTTCTGTGAAGTTCCAGC	0.463000													35	92					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59610056	59610056	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:59610056C>T	ENST00000541311.1	-	4	530	c.295_splice	c.e4-1	p.S99_splice	GIF_ENST00000257248.2_Splice_Site_p.S124_splice			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	124					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						AGCGTTGGGGCCTCCGAAGGG	0.517000													22	46					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24909430	24909430	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:24909430G>A	ENST00000347898.3	+	10	1628	c.1006_splice	c.e10+1	p.D336_splice	SLC5A11_ENST00000449109.2_Splice_Site_p.R203_splice|SLC5A11_ENST00000565769.1_Splice_Site_p.D272_splice|SLC5A11_ENST00000545376.1_Splice_Site_p.D266_splice|SLC5A11_ENST00000539472.1_Splice_Site_p.D272_splice|SLC5A11_ENST00000568579.1_Splice_Site_p.D266_splice|SLC5A11_ENST00000569071.1_Splice_Site_p.R203_splice|SLC5A11_ENST00000424767.2_Splice_Site_p.D301_splice|SLC5A11_ENST00000567758.1_Splice_Site_p.D301_splice	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	336					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		CCTCTTCCCAGGTGAGAACAC	0.493000													6	65					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450876	105450876	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:105450876C>T	ENST00000337685.2	+	5	2236	c.1451C>T	c.(1450-1452)tCt>tTt	p.S484F	MUM1L1_ENST00000372552.1_Missense_Mutation_p.S484F|MUM1L1_ENST00000357175.2_Missense_Mutation_p.S484F	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	484										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						GGTTGTGGTTCTTTCACGGGC	0.393000													14	26					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15115135	15115135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:15115135G>A	ENST00000378217.3	+	9	1051	c.864G>A	c.(862-864)ggG>ggA	p.G288G	OLAH_ENST00000485251.1_3'UTR|OLAH_ENST00000378228.3_Silent_p.G235G	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	235					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						AGCTTCCAGGGGGTCACTTTT	0.343000													20	43					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576322	158576322	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158576322C>T	ENST00000361284.1	+	1	94	c.94C>T	c.(94-96)Ctc>Ttc	p.L32F		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					TGCCTTGTTCCTCTCTCTGTA	0.502000													55	135					0	0	1	0	0
ZNF221	7638	broad.mit.edu	37	19	44470085	44470085	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:44470085C>T	ENST00000251269.5	+	6	759	c.431C>T	c.(430-432)tCt>tTt	p.S144F	ZNF221_ENST00000592350.1_Missense_Mutation_p.S144F|ZNF221_ENST00000587682.1_Missense_Mutation_p.S144F	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				AGGAACAGCTCTCAGTTCTTC	0.443000													27	110					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66434820	66434820	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:66434820G>A	ENST00000341529.3	+	11	1886	c.1738G>A	c.(1738-1740)Gag>Aag	p.E580K	CDH5_ENST00000539168.1_Missense_Mutation_p.E19K	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	580	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CAAGTGCAACGAGCAGGGCGA	0.602000													17	69					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	326596	326596	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:326596G>A	ENST00000264819.4	-	6	506	c.496C>T	c.(496-498)Cgt>Tgt	p.R166C		NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.R166C(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGGAAACGAGCTTTGGGA	0.562000													22	64					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26164846	26164846	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26164846C>T	ENST00000335473.7	+	4	1213	c.963C>T	c.(961-963)ttC>ttT	p.F321F	MYO18B_ENST00000536101.1_Silent_p.F321F|MYO18B_ENST00000407587.2_Silent_p.F321F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	321						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GGGGAGGTTTCCTGGGAAGAA	0.532000													4	17					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22089606	22089606	+	Translation_Start_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:22089606C>T	ENST00000261200.4	-	1	2	c.3G>A	c.(1-3)atG>atA	p.M1I	ABCC9_ENST00000326684.4_Start_Codon_SNP_p.M1I|ABCC9_ENST00000261201.4_Start_Codon_SNP_p.M1I|ABCC9_ENST00000345162.2_Start_Codon_SNP_p.M1I|ABCC9_ENST00000538350.1_Start_Codon_SNP_p.M1I	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATGAAAGGCTCATTTCTTCTT	0.333000													23	58					0	0	1	0	0
SPANXD	64648	broad.mit.edu	37	X	140785651	140785651	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140785651C>T	ENST00000370515.3	-	2	598	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K		NM_032417.2|NM_145665.1	NP_115793.1|NP_663698.1			SPANX family, member D											breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	9	Acute lymphoblastic leukemia(192;7.65e-05)					ACCATTATTTCCATGAATTCC	0.433000													81	74					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177247750	177247750	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177247750C>T	ENST00000361539.4	+	7	1376	c.1064C>T	c.(1063-1065)tCc>tTc	p.S355F	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		355						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						TTCCTGAACTCCACAGCTATC	0.562000													71	236					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79267429	79267429	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:79267429C>T	ENST00000428286.1	-	11	8650	c.7450G>A	c.(7450-7452)Gaa>Aaa	p.E2484K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E2843K|PRUNE2_ENST00000443509.2_Missense_Mutation_p.E92K|PRUNE2_ENST00000466266.2_5'UTR|PRUNE2_ENST00000223609.6_Missense_Mutation_p.E107K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2843					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GAATCTGCTTCATCGGGGGTA	0.393000													56	220					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284619	152284619	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152284619C>T	ENST00000368799.1	-	3	2778	c.2743G>A	c.(2743-2745)Gaa>Aaa	p.E915K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	915	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAAGCTTCATGGTGACGT	0.567000									Ichthyosis				160	405					0	0	1	0	0
ZBTB38	253461	broad.mit.edu	37	3	141163850	141163850	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141163850C>T	ENST00000514251.1	+	4	2899	c.2620C>T	c.(2620-2622)Cct>Tct	p.P874S	ZBTB38_ENST00000441582.2_Missense_Mutation_p.P874S|ZBTB38_ENST00000321464.5_Missense_Mutation_p.P875S			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	874					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						GCAGGAGGAGCCTTTGCCACA	0.478000													21	55					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103705025	103705025	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:103705025G>A	ENST00000245312.3	-	3	1126	c.530C>T	c.(529-531)tCc>tTc	p.S177F		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	177					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CATTCCAATGGAAACAGGAAC	0.388000													25	67					0	0	1	0	0
P4HA3	283208	broad.mit.edu	37	11	74009390	74009390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:74009390C>T	ENST00000331597.4	-	4	629	c.584G>A	c.(583-585)gGg>gAg	p.G195E	P4HA3_ENST00000427714.2_Missense_Mutation_p.G195E	NM_182904.3	NP_878907.1	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha polypeptide III	195						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(1)	15	Breast(11;2.31e-05)					GTAATAATCCCCCATGTCATA	0.458000													46	115					0	0	1	0	0
SLC47A1	55244	broad.mit.edu	37	17	19470440	19470440	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:19470440G>A	ENST00000270570.4	+	14	1294	c.1208G>A	c.(1207-1209)gGa>gAa	p.G403E	SLC47A1_ENST00000571335.1_Missense_Mutation_p.G208E|SLC47A1_ENST00000395585.1_Missense_Mutation_p.G403E|SLC47A1_ENST00000436810.2_Missense_Mutation_p.G380E|SLC47A1_ENST00000575023.1_Intron|SLC47A1_ENST00000457293.1_Missense_Mutation_p.G403E|RP11-1113L8.1_ENST00000574267.1_RNA	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	403						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					AGGGGGAGTGGAAATCAGAAG	0.542000													65	83					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58118620	58118620	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:58118620G>A	ENST00000357272.4	+	26	4641	c.4476G>A	c.(4474-4476)atG>atA	p.M1492I	FLNB_ENST00000358537.3_Missense_Mutation_p.M1492I|FLNB_ENST00000295956.4_Missense_Mutation_p.M1492I|FLNB_ENST00000429972.2_Missense_Mutation_p.M1492I|FLNB_ENST00000490882.1_Missense_Mutation_p.M1523I|FLNB_ENST00000348383.5_Missense_Mutation_p.M1492I|FLNB_ENST00000419752.2_Missense_Mutation_p.M1323I|FLNB_ENST00000493452.1_Missense_Mutation_p.M1323I			O75369	FLNB_HUMAN	filamin B, beta	1492	Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GACCTTACATGGTCTCAGTTA	0.512000													13	27					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668568	176668568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:176668568G>A	ENST00000367662.3	+	8	4243	c.3079G>A	c.(3079-3081)Gag>Aag	p.E1027K		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1027					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CACCTTTGATGAGAGGATAGA	0.562000													59	95					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91766302	91766302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91766302C>T	ENST00000389857.6	-	21	3834	c.3748G>A	c.(3748-3750)Gag>Aag	p.E1250K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1250					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTCTGGTTCTCGCCCATGGCG	0.652000													3	9					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29049290	29049290	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29049290C>T	ENST00000257189.4	+	12	1958	c.1875C>T	c.(1873-1875)ctC>ctT	p.L625L		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	625					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCCTGCTGCTCCTTGGTCTCC	0.597000													29	68					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62599145	62599145	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:62599145C>T	ENST00000512091.1	+	7	1815	c.1068C>T	c.(1066-1068)ccC>ccT	p.P356P	LPHN3_ENST00000507164.1_Silent_p.P424P|LPHN3_ENST00000506746.1_Silent_p.P424P|LPHN3_ENST00000514591.1_Silent_p.P356P|LPHN3_ENST00000545650.1_Silent_p.P356P|LPHN3_ENST00000508693.1_Silent_p.P424P|LPHN3_ENST00000504896.1_Silent_p.P356P|LPHN3_ENST00000514996.1_Silent_p.P356P|LPHN3_ENST00000511324.1_Silent_p.P424P|LPHN3_ENST00000507625.1_Silent_p.P424P|LPHN3_ENST00000509896.1_Silent_p.P424P|LPHN3_ENST00000508946.1_Silent_p.P356P|LPHN3_ENST00000506720.1_Silent_p.P424P|LPHN3_ENST00000506700.1_Silent_p.P356P|LPHN3_ENST00000514157.1_Silent_p.P356P			Q9HAR2	LPHN3_HUMAN	latrophilin 3	356	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TGGATGTACCCTTTCCTAATT	0.388000													7	36					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080233	29080233	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29080233G>A	ENST00000377169.1	+	1	566	c.566G>A	c.(565-567)cGa>cAa	p.R189Q		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						GCACTTCTGCGATTATCGTGT	0.448000													24	72					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104170845	104170845	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:104170845G>A	ENST00000020673.5	-	9	2497	c.1971C>T	c.(1969-1971)ctC>ctT	p.L657L	PSD_ENST00000406432.1_Silent_p.L657L	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	657	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TGAGCAGCATGAGCGCACAGG	0.647000													14	73					0	0	1	0	0
TUBAL3	79861	broad.mit.edu	37	10	5435776	5435776	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5435776G>A	ENST00000380419.3	-	4	1082	c.1045C>T	c.(1045-1047)Cag>Tag	p.Q349*	TUBAL3_ENST00000479328.1_Nonsense_Mutation_p.Q309*	NM_024803.2	NP_079079.1	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	349					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(7)|prostate(2)|skin(3)	25						TCTACAAACTGAACAGAGTGC	0.567000													23	40					0	0	1	0	0
CCL28	56477	broad.mit.edu	37	5	43412406	43412406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:43412406C>T	ENST00000361115.4	-	1	87	c.13G>A	c.(13-15)Gga>Aga	p.G5R	CCL28_ENST00000537013.1_Missense_Mutation_p.G5R	NM_148672.2	NP_683513.1	Q9NRJ3	CCL28_HUMAN	chemokine (C-C motif) ligand 28	5					chemotaxis|immune response	extracellular space	chemokine activity			kidney(3)|lung(3)|ovary(1)	7						ATGGCGAGTCCTCTCTGCTGC	0.572000													7	40					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25887578	25887578	+	Missense_Mutation	SNP	C	C	T	rs151132862		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25887578C>T	ENST00000376351.3	+	11	3382	c.3023C>T	c.(3022-3024)cCt>cTt	p.P1008L	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1008						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GAGGTGTGTCCTTGGGAGGTT	0.478000													33	56					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333092	70333092	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:70333092G>T	ENST00000338508.4	-	32	3308	c.3309C>A	c.(3307-3309)ttC>ttA	p.F1103L	SHANK2_ENST00000449833.2_Missense_Mutation_p.F507L|SHANK2_ENST00000423696.2_Missense_Mutation_p.F723L|SHANK2_ENST00000409161.1_Missense_Mutation_p.F506L			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	723					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTGTGGAGAGGAAGGCCGGGG	0.692000													19	42					4.96729e-08	4.98302e-08	1	1	0
COL27A1	85301	broad.mit.edu	37	9	116930445	116930445	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:116930445C>T	ENST00000356083.3	+	3	1001	c.610C>T	c.(610-612)Ccg>Tcg	p.P204S		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	204	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						GAAGATGAACCCGCATGCAGT	0.602000													20	50					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	99999541	99999541	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:99999541C>T	ENST00000398027.2	-	17	1842	c.1595G>A	c.(1594-1596)gGc>gAc	p.G532D	ZCWPW1_ENST00000360951.4_Intron|ZCWPW1_ENST00000490721.1_Intron|ZCWPW1_ENST00000324725.6_Intron	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	532							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATTCCCTTGGCCTTCTTTCCT	0.527000													38	93					0	0	1	0	0
INTU	27152	broad.mit.edu	37	4	128595288	128595288	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:128595288C>T	ENST00000335251.5	+	6	1204	c.1101C>T	c.(1099-1101)ctC>ctT	p.L367L	INTU_ENST00000296461.5_Silent_p.L367L	NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	367										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						GTTCATCCCTCCTTTTAAATG	0.303000													11	49					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584886	30584886	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30584886C>T	ENST00000217299.3	+	3	1540	c.1366C>T	c.(1366-1368)Cgt>Tgt	p.R456C		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	456						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TTGCATCTTCCGTAAGGCCTC	0.632000													42	84					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186545280	186545280	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186545280G>A	ENST00000431808.1	-	14	1854	c.1291C>T	c.(1291-1293)Cgc>Tgc	p.R431C	SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.R335C|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.R531C|SORBS2_ENST00000284776.7_Missense_Mutation_p.R431C|SORBS2_ENST00000319471.9_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	431						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.R431C(1)		endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CCGTTACTGCGAACCTCCGGG	0.592000													22	56					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53072390	53072390	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53072390C>T	ENST00000252244.3	-	2	800	c.742G>A	c.(742-744)Gat>Aat	p.D248N		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	248	Coil 1B.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding	p.D248N(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CGAGATTGATCACTCTTCAGT	0.473000													26	105					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140737029	140737029	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140737029C>T	ENST00000571252.1	+	1	2262	c.2262C>T	c.(2260-2262)tcC>tcT	p.S754S	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACCTATTCCCACGAGGTCT	0.602000													27	123					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4649113	4649113	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4649113G>A	ENST00000433935.1	+	14	2114		c.e14-1		ZMYND15_ENST00000573751.2_Splice_Site|ZMYND15_ENST00000592813.1_Splice_Site|ZMYND15_ENST00000269289.6_Splice_Site	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15								zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						CGCCCCCGCAGGTACTGCAAT	0.741000													8	11					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6128044	6128044	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6128044A>G	ENST00000261405.5	-	28	4794	c.4540T>C	c.(4540-4542)Ttc>Ctc	p.F1514L		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1514	VWFA 2.		F -> C (in VWD2).		blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CTCCTGTTGAAGTCGGCTTCA	0.572000													7	41					0	0	1	0	0
PIGT	51604	broad.mit.edu	37	20	44050117	44050117	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:44050117C>T	ENST00000279036.6	+	9	1208	c.1128C>T	c.(1126-1128)caC>caT	p.H376H	PIGT_ENST00000543458.2_Silent_p.H320H|PIGT_ENST00000545755.1_Silent_p.H114H|PIGT_ENST00000372689.5_Intron|PIGT_ENST00000535404.1_Silent_p.H221H|PIGT_ENST00000341555.5_Silent_p.H182H|PIGT_ENST00000279035.9_Silent_p.H274H	NM_015937.5	NP_057021.2	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class T	376					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(1)|endometrium(2)|kidney(5)|large_intestine(4)|lung(7)|pancreas(1)|skin(1)|stomach(1)	22		Myeloproliferative disorder(115;0.0122)				ACAACACCCACCCATACCGGG	0.622000													13	79					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117299059	117299059	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:117299059G>A	ENST00000321322.6	-	33	6328	c.6327C>T	c.(6325-6327)tcC>tcT	p.S2109S	DSCAML1_ENST00000527706.1_Silent_p.S1839S	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	2049					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCAGGGTGTAGGATTTGGAGT	0.627000													25	70					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91169121	91169121	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:91169121C>T	ENST00000420329.2	+	10	1010	c.863C>T	c.(862-864)gCc>gTc	p.A288V	CRTC3_ENST00000268184.6_Missense_Mutation_p.A288V|RP11-387D10.2_ENST00000559531.1_RNA	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	288					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CCCCTGCCAGCCTCCCTGGAC	0.542000			T	MAML2	salivary gland mucoepidermoid								71	531					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27997756	27997756	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:27997756C>T	ENST00000441525.1	-	1	1810	c.1696G>A	c.(1696-1698)Gat>Aat	p.D566N		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	566								p.D566N(1)		NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						GCTCCATGATCTCTCCAGCCG	0.512000													12	69					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18149669	18149669	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:18149669G>A	ENST00000375406.1	+	2	382	c.166G>A	c.(166-168)Gac>Aac	p.D56N		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	56						cytoplasm|cytoskeleton		p.D56Y(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CCTGGGCATCGACATTTGCCA	0.572000													56	106					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141952422	141952422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:141952422G>A	ENST00000552471.1	-	4	765	c.446C>T	c.(445-447)cCc>cTc	p.P149L	PRSS58_ENST00000547058.2_Missense_Mutation_p.P149L			Q8IYP2	PRS58_HUMAN	protease, serine, 58	149	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						CAGTGAATCGGGCTCTTTGTC	0.373000													35	87					0	0	1	0	0
ATP6V1G3	127124	broad.mit.edu	37	1	198492560	198492560	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:198492560C>T	ENST00000367381.1	-	5	441	c.336G>A	c.(334-336)atG>atA	p.M112I	ATP6V1G3_ENST00000489986.1_Missense_Mutation_p.M112I|ATP6V1G3_ENST00000367382.1_Missense_Mutation_p.M106I|ATP6V1G3_ENST00000309309.7_3'UTR|ATP6V1G3_ENST00000281087.2_Missense_Mutation_p.M106I			Q96LB4	VATG3_HUMAN	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	106					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	7						TTTCTGGTTTCATGTCACAGA	0.398000													8	30					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50757272	50757272	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:50757272G>A	ENST00000300589.2	+	9	2964	c.2859G>A	c.(2857-2859)aaG>aaA	p.K953K		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	953					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TGCTGGCAAAGAACGTCATGC	0.527000													8	33					0	0	1	0	0
DOCK1	1793	broad.mit.edu	37	10	129231625	129231625	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:129231625C>T	ENST00000280333.6	+	48	5039	c.4930C>T	c.(4930-4932)Cct>Tct	p.P1644S		NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1644					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CTCATCCCGCCCTCTGTCTGT	0.612000													55	91					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89346952	89346952	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89346952G>A	ENST00000301030.4	-	9	6458	c.5998C>T	c.(5998-6000)Ctc>Ttc	p.L2000F	ANKRD11_ENST00000378330.2_Missense_Mutation_p.L2000F	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2000	Pro-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCAGAGTGGAGGGGGTCCGCG	0.701000													11	30					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56349081	56349081	+	Silent	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:56349081G>T	ENST00000340482.3	-	10	2237	c.2061C>A	c.(2059-2061)ggC>ggA	p.G687G	MPO_ENST00000225275.3_Silent_p.G655G			P05164	PERM_HUMAN	myeloperoxidase	655					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GGCCCACGCGGCCTTTGCGCT	0.632000													14	34					8.60227e-14	8.64706e-14	1	1	0
KCNQ3	3786	broad.mit.edu	37	8	133152366	133152366	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133152366C>T	ENST00000388996.4	-	11	1945	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	KCNQ3_ENST00000519445.1_Missense_Mutation_p.E509K|KCNQ3_ENST00000521134.1_Missense_Mutation_p.E389K	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	509					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ATCATGTCTTCGATGGGGAAG	0.627000													17	57					0	0	1	0	0
SP140L	93349	broad.mit.edu	37	2	231249970	231249970	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231249970G>A	ENST00000243810.6	+	9	735	c.735G>A	c.(733-735)tcG>tcA	p.S245S	SP140L_ENST00000444636.1_Silent_p.S245S|SP140L_ENST00000415673.2_Silent_p.S245S|SP140L_ENST00000396563.4_Silent_p.S245S			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	245						nucleus	DNA binding|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						AGCTGGTCTCGAGTGAAAAGA	0.458000													12	84					0	0	1	0	0
CORO1A	11151	broad.mit.edu	37	16	30199825	30199825	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30199825G>A	ENST00000219150.5	+	10	1514	c.1209G>A	c.(1207-1209)gaG>gaA	p.E403E	CORO1A_ENST00000565497.1_Intron|CORO1A_ENST00000570045.1_Silent_p.E403E	NM_001193333.2|NM_007074.3	NP_001180262.1|NP_009005.1	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	403					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	9						AGAGCCGGGAGCTGAGGGTCA	0.682000													20	38					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2933011	2933011	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:2933011G>A	ENST00000381130.2	+	4	341	c.340_splice	c.e4-1	p.G114_splice		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	114						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TTACTTTTAGGCAAATGGCAC	0.453000													5	11					0	0	1	0	0
NOP2	4839	broad.mit.edu	37	12	6670901	6670901	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6670901G>A	ENST00000541778.1	-	11	1612	c.1124C>T	c.(1123-1125)gCc>gTc	p.A375V	NOP2_ENST00000322166.5_Missense_Mutation_p.A379V|NOP2_ENST00000382421.3_Missense_Mutation_p.A412V|NOP2_ENST00000545200.1_Missense_Mutation_p.A375V|NOP2_ENST00000537442.1_Missense_Mutation_p.A379V|NOP2_ENST00000399466.2_Missense_Mutation_p.A375V|NOP2_ENST00000542015.1_Intron			P46087	NOP2_HUMAN	NOP2 nucleolar protein	379					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	19						GGGTGCCAAGGCCATGACGGG	0.607000													4	22					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135866329	135866329	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135866329C>T	ENST00000339463.3	+	11	1704	c.885C>T	c.(883-885)agC>agT	p.S295S	GFI1B_ENST00000372124.1_Silent_p.S249S|GFI1B_ENST00000372123.1_Silent_p.S249S|GFI1B_ENST00000372122.1_Silent_p.S295S|GFI1B_ENST00000450530.1_Silent_p.S295S|GFI1B_ENST00000534944.1_Silent_p.S249S			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	295	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		TCACCCACAGCCGCAAGCACA	0.632000													13	52					0	0	1	0	0
DENND4A	10260	broad.mit.edu	37	15	65968957	65968957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:65968957G>A	ENST00000443035.3	-	24	4407	c.4192C>T	c.(4192-4194)Cgt>Tgt	p.R1398C	DENND4A_ENST00000431932.2_Missense_Mutation_p.R1355C	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	1355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						AGACTGGTACGATCAGAACTT	0.363000													8	29					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76572088	76572088	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:76572088C>T	ENST00000307431.8	+	20	3453	c.3068C>T	c.(3067-3069)tCc>tTc	p.S1023F	CNTNAP4_ENST00000377504.4_Missense_Mutation_p.S975F|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.S1027F|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.S951F	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1024					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AGTAAAAACTCCAGCTCCCAC	0.333000													10	46					0	0	1	0	0
LINC00696	100128378	broad.mit.edu	37	3	52097298	52097298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52097298C>T	ENST00000541313.1	-	1	269	c.270G>A	c.(268-270)acG>acA	p.T90T																								ACAGAACATTCGTGCTACCAA	0.542000													87	180					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204926948	204926948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:204926948C>T	ENST00000367172.4	+	8	1028	c.700C>T	c.(700-702)Ctc>Ttc	p.L234F	NFASC_ENST00000404076.1_Missense_Mutation_p.L228F|NFASC_ENST00000513543.1_Missense_Mutation_p.L228F|NFASC_ENST00000367171.4_Missense_Mutation_p.L234F|NFASC_ENST00000403080.1_Missense_Mutation_p.L234F|NFASC_ENST00000339876.6_Missense_Mutation_p.L234F|NFASC_ENST00000539706.1_Missense_Mutation_p.L228F|NFASC_ENST00000404907.1_Missense_Mutation_p.L228F|NFASC_ENST00000360049.4_Missense_Mutation_p.L228F|NFASC_ENST00000367170.4_Missense_Mutation_p.L234F|NFASC_ENST00000401399.1_Missense_Mutation_p.L234F|NFASC_ENST00000367169.4_Missense_Mutation_p.L234F|NFASC_ENST00000338586.6_Missense_Mutation_p.L234F|NFASC_ENST00000338515.6_Missense_Mutation_p.L234F			O94856	NFASC_HUMAN	neurofascin	234					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCTCAAGGTCCTCACCAGTAA	0.577000													39	82					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106917020	106917020	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:106917020G>A	ENST00000369701.3	+	10	1834	c.1607G>A	c.(1606-1608)gGa>gAa	p.G536E		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	536						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GACCTGAGAGGAAGCCCAGTG	0.567000													8	43					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997368	115997368	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:115997368C>T	ENST00000264363.2	-	2	1503	c.825G>A	c.(823-825)ttG>ttA	p.L275L		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	275	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GCCAAAAGTTCAAGTTGTTGC	0.453000													56	148					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70514339	70514339	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:70514339C>T	ENST00000377844.4	-	4	1606	c.847G>A	c.(847-849)Gag>Aag	p.E283K	KLHL1_ENST00000545028.1_Missense_Mutation_p.E90K	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	283					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AGAAGGTTCTCAATGGTGTCC	0.393000													13	27					0	0	1	0	0
CHRNA6	8973	broad.mit.edu	37	8	42611578	42611578	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:42611578G>A	ENST00000276410.2	-	5	1119	c.764C>T	c.(763-765)tCa>tTa	p.S255L	CHRNA6_ENST00000534622.1_Missense_Mutation_p.S240L	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	255						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GGTTAGAAATGAAATAAAGAG	0.378000													7	63					0	0	1	0	0
APCDD1L	164284	broad.mit.edu	37	20	57035978	57035978	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:57035978C>T	ENST00000371149.3	-	4	1604	c.1374G>A	c.(1372-1374)gaG>gaA	p.E458E	APCDD1L_ENST00000439429.1_Silent_p.E469E	NM_153360.1	NP_699191.1	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated 1-like	458						integral to membrane				large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(1)	18	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			AGTCGGGGGCCTCCCCATGAC	0.627000													28	74					0	0	1	0	0
LBP	3929	broad.mit.edu	37	20	36993269	36993269	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:36993269C>T	ENST00000217407.2	+	8	945	c.784C>T	c.(784-786)Ctc>Ttc	p.L262F		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	262					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				TCCAGTTACCCTCCTTGCTGC	0.493000													61	145					0	0	1	0	0
TRABD2A	129293	broad.mit.edu	37	2	85051079	85051079	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:85051079C>T	ENST00000335459.5	-	5	1390	c.1185G>A	c.(1183-1185)gaG>gaA	p.E395E	TRABD2A_ENST00000479944.1_5'UTR|TRABD2A_ENST00000409520.2_Silent_p.E444E	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		CGCCTGACCTCTCCTCCAGGC	0.647000													9	24					0	0	1	0	0
OR10H5	284433	broad.mit.edu	37	19	15905626	15905626	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15905626C>T	ENST00000308940.8	+	1	866	c.768C>T	c.(766-768)gcC>gcT	p.A256A		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						ATGGCTTTGCCTCCGTCATTT	0.572000													18	50					0	0	1	0	0
PRR11	55771	broad.mit.edu	37	17	57270872	57270872	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:57270872C>T	ENST00000262293.4	+	5	734	c.422C>T	c.(421-423)tCc>tTc	p.S141F		NM_018304.3	NP_060774.2	Q96HE9	PRR11_HUMAN	proline rich 11	141										breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|pancreas(1)	16	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GAAAGTTCTTCCTGTCCAAGC	0.418000													17	87					0	0	1	0	0
LCN1	3933	broad.mit.edu	37	9	138415806	138415806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:138415806G>A	ENST00000263598.2	+	4	433	c.373G>A	c.(373-375)Ggg>Agg	p.G125R	LCN1_ENST00000371781.3_Missense_Mutation_p.G125R	NM_001252617.1|NM_001252618.1|NM_001252619.1|NM_002297.3	NP_001239546.1|NP_001239547.1|NP_001239548.1|NP_002288.1	P31025	LCN1_HUMAN	lipocalin 1	125					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)	13		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		CGAGCTGCACGGGAAGCCGGT	0.637000													11	42					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112357	248112357	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:248112357C>T	ENST00000357191.3	+	1	198	c.198C>T	c.(196-198)tcC>tcT	p.S66S	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTCAGCTCTCCCTCATTGACC	0.438000													129	391					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634495	156634495	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156634495G>A	ENST00000296518.7	+	7	1541	c.1332G>A	c.(1330-1332)gaG>gaA	p.E444E	GUCY1A3_ENST00000511108.1_Silent_p.E444E|GUCY1A3_ENST00000455639.2_Silent_p.E444E|GUCY1A3_ENST00000513574.1_Silent_p.E444E|GUCY1A3_ENST00000393832.3_Silent_p.E186E|GUCY1A3_ENST00000511507.1_Silent_p.E444E|GUCY1A3_ENST00000506455.1_Silent_p.E444E			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	444					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		AAGCCCTGGAGGAGGAGAAGA	0.527000													26	75					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240611	3240611	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:3240611C>T	ENST00000217939.6	-	5	3269	c.3115G>A	c.(3115-3117)Gac>Aac	p.D1039N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1039						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGGATGTTGTCTGTCAGTCCT	0.428000													68	38					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	666022	666022	+	Silent	SNP	C	C	T	rs150365241		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:666022C>T	ENST00000266383.5	+	15	2383	c.2370C>T	c.(2368-2370)ttC>ttT	p.F790F		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	790						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	p.F790F(1)		breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TGGTCCACTTCGTCGTGCCTG	0.607000													7	33					0	0	1	0	0
FEZ2	9637	broad.mit.edu	37	2	36782889	36782889	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:36782889G>A	ENST00000379245.4	-	8	1111	c.1063C>T	c.(1063-1065)Ctt>Ttt	p.L355F	FEZ2_ENST00000305852.7_Missense_Mutation_p.L157F|FEZ2_ENST00000405912.3_Missense_Mutation_p.L328F|FEZ2_ENST00000487919.1_5'UTR	NM_001042548.1	NP_001036013.1	Q9UHY8	FEZ2_HUMAN	fasciculation and elongation protein zeta 2 (zygin II)	328					axon guidance|signal transduction		protein binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	7		all_hematologic(82;0.21)				ATGGCACGAAGAACTGCAAAA	0.333000													11	32					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52554926	52554926	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:52554926G>A	ENST00000321725.6	+	55	5889	c.5813G>A	c.(5812-5814)aGg>aAg	p.R1938K		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1938					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTTTGGGGTAGGCCCCAAGGC	0.642000													16	72					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158608031	158608031	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158608031C>T	ENST00000368148.3	-	36	5161	c.4980_splice	c.e36-1	p.D1661_splice	SPTA1_ENST00000368147.3_Splice_Site_p.D1661_splice	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1661					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTGAGTGCATCCTAGAAAGTC	0.433000													8	22					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207110583	207110583	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207110583G>A	ENST00000356495.4	-	4	1085	c.902C>T	c.(901-903)cCc>cTc	p.P301L		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	301	Ig-like V-type 3.					extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTTGTCCTGGGGGTTGAGCAG	0.587000													27	50					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94944769	94944769	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:94944769G>A	ENST00000222381.3	-	4	466	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	PON1_ENST00000542556.1_Missense_Mutation_p.P79S	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	79					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GGACTGTTGGGGTTGAAGCTC	0.393000													16	71					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25885707	25885707	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25885707G>A	ENST00000376351.3	+	10	2493	c.2134G>A	c.(2134-2136)Gag>Aag	p.E712K	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	712						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CTTGGATCCAGAGGACATTCG	0.488000													20	72					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577764	9577764	+	Missense_Mutation	SNP	C	C	T	rs139799240	by1000genomes	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9577764C>T	ENST00000301480.4	-	10	2072	c.1859G>A	c.(1858-1860)cGa>cAa	p.R620Q		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	620					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						AGTGTGTCTTCGTAAATGTTT	0.393000													46	119					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130488626	130488626	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:130488626T>G	ENST00000373289.3	+	10	1448	c.1368T>G	c.(1366-1368)atT>atG	p.I456M	TTC16_ENST00000489226.1_3'UTR	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	456							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						TGCAGAACATTTTTGGGGCCC	0.607000													6	60					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27941044	27941044	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:27941044G>A	ENST00000374005.3	-	11	1434	c.1146C>T	c.(1144-1146)gaC>gaT	p.D382D	FGR_ENST00000399173.1_Silent_p.D382D|FGR_ENST00000374004.1_Silent_p.D382D|FGR_ENST00000545953.1_Silent_p.D316D	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	382	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CTGCCCTCAGGTCGCGGTGAA	0.582000													10	25					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50610686	50610686	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:50610686G>A	ENST00000371824.1	+	2	324	c.67G>A	c.(67-69)Gga>Aga	p.G23R	ELAVL4_ENST00000448907.2_Missense_Mutation_p.G26R|ELAVL4_ENST00000371823.4_Missense_Mutation_p.G23R|ELAVL4_ENST00000492299.1_3'UTR|ELAVL4_ENST00000371819.1_Missense_Mutation_p.G28R|ELAVL4_ENST00000371821.1_Missense_Mutation_p.G28R|ELAVL4_ENST00000371827.1_Missense_Mutation_p.G23R|ELAVL4_ENST00000357083.4_Missense_Mutation_p.G40R			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	23					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						TACAAGCAATGGACCCTCCAG	0.418000													7	54					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86894926	86894926	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:86894926C>T	ENST00000376238.4	-	16	1841	c.1792G>A	c.(1792-1794)Ggg>Agg	p.G598R	SLC28A3_ENST00000537648.1_Missense_Mutation_p.G529R|RP11-380F14.2_ENST00000419815.1_RNA	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	598					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GCCACGGTCCCCGCAATCAGA	0.572000													6	28					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746607	77746607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:77746607G>A	ENST00000409088.3	-	3	802	c.388C>T	c.(388-390)Cac>Tac	p.H130Y	LRRTM4_ENST00000409911.1_Missense_Mutation_p.H131Y|LRRTM4_ENST00000409884.1_Missense_Mutation_p.H130Y|LRRTM4_ENST00000409093.1_Missense_Mutation_p.H130Y|LRRTM4_ENST00000409282.1_Missense_Mutation_p.H131Y	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	130						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		GGAACTGGGTGAAATGTTTTA	0.388000													36	44					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53607910	53607910	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53607910G>A	ENST00000425354.2	-	7	1233	c.746C>T	c.(745-747)cCt>cTt	p.P249L	RARG_ENST00000394426.1_Missense_Mutation_p.P249L|RARG_ENST00000543762.1_5'UTR|RARG_ENST00000543726.1_Missense_Mutation_p.P227L|RARG_ENST00000327550.3_Missense_Mutation_p.P177L|RARG_ENST00000338561.5_Missense_Mutation_p.P238L	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	249	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TGTAAAGCCAGGCAACCGCTT	0.572000											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	159					0	0	1	0	0
PIAS1	8554	broad.mit.edu	37	15	68445979	68445979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68445979C>T	ENST00000545237.1	+	8	1627	c.886C>T	c.(886-888)Ctt>Ttt	p.L296F	PIAS1_ENST00000249636.6_Missense_Mutation_p.L294F			O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	294					androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)	24						AACAGTTCTTCTTCAGAGGTT	0.323000													29	41					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	31066223	31066223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:31066223G>A	ENST00000399914.1	-	2	799	c.278C>T	c.(277-279)tCg>tTg	p.S93L	GRIK1_ENST00000389125.3_Missense_Mutation_p.S93L|GRIK1_ENST00000309434.7_Missense_Mutation_p.S93L|GRIK1_ENST00000327783.4_Missense_Mutation_p.S93L|GRIK1_ENST00000535441.1_Missense_Mutation_p.S93L|GRIK1_ENST00000389124.2_Missense_Mutation_p.S93L|GRIK1_ENST00000399907.1_Missense_Mutation_p.S93L|GRIK1_ENST00000399909.1_Missense_Mutation_p.S93L|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000399913.1_Missense_Mutation_p.S93L			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	93					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	ACCTCTCCGCGAGGCTTCAAA	0.423000													46	100					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26743007	26743007	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:26743007G>A	ENST00000396005.3	-	1	564	c.255C>T	c.(253-255)ttC>ttT	p.F85F	SLC5A12_ENST00000280467.6_Silent_p.F85F	NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	85					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GGTAAGCAATGAAGAAGACTA	0.488000													22	70					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124392769	124392769	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124392769C>T	ENST00000368909.3	+	49	6179	c.6073C>T	c.(6073-6075)Ccc>Tcc	p.P2025S	DMBT1_ENST00000330163.4_Missense_Mutation_p.P1397S|DMBT1_ENST00000368955.3_Missense_Mutation_p.P2015S|DMBT1_ENST00000359586.6_Missense_Mutation_p.P745S|DMBT1_ENST00000368956.2_Missense_Mutation_p.P1397S|DMBT1_ENST00000344338.3_Missense_Mutation_p.P2015S|DMBT1_ENST00000338354.3_Missense_Mutation_p.P2025S	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2025	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCCATTCTATCCCGGGAACTA	0.507000													32	93					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750162	140750162	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140750162G>A	ENST00000576222.1	+	1	332	c.201G>A	c.(199-201)cgG>cgA	p.R67R	PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAACCTGCGGGTTATTGCAG	0.542000													18	195					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35619167	35619167	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:35619167G>A	ENST00000540320.1	+	3	1144	c.610G>A	c.(610-612)Gga>Aga	p.G204R	NBEA_ENST00000379939.2_Missense_Mutation_p.G204R|NBEA_ENST00000310336.4_Missense_Mutation_p.G204R|NBEA_ENST00000400445.3_Missense_Mutation_p.G204R			Q8NFP9	NBEA_HUMAN	neurobeachin	204						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CATGCTTCGAGGAGAAAGTGG	0.403000													6	21					0	0	1	0	0
ODAM	54959	broad.mit.edu	37	4	71063012	71063012	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71063012G>A	ENST00000396094.2	+	3	163	c.115G>A	c.(115-117)Ggt>Agt	p.G39S		NM_017855.3	NP_060325.3	A1E959	ODAM_HUMAN	odontogenic, ameloblast asssociated	39					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(3)|skin(2)	20						TCTTAATAATGGTCAACTTTT	0.279000													23	87					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123298188	123298188	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:123298188G>A	ENST00000358487.5	-	6	938	c.666C>T	c.(664-666)gtC>gtT	p.V222V	FGFR2_ENST00000356226.4_Silent_p.V107V|FGFR2_ENST00000351936.6_Silent_p.V222V|FGFR2_ENST00000490349.1_5'UTR|FGFR2_ENST00000369056.1_Silent_p.V222V|FGFR2_ENST00000369061.4_Silent_p.V222V|FGFR2_ENST00000359354.2_Silent_p.V222V|FGFR2_ENST00000346997.2_Silent_p.V222V|FGFR2_ENST00000360144.3_Silent_p.V133V|FGFR2_ENST00000369060.4_Silent_p.V222V|FGFR2_ENST00000457416.2_Silent_p.V222V|FGFR2_ENST00000357555.5_Silent_p.V133V|FGFR2_ENST00000369059.1_Silent_p.V107V	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	222	Ig-like C2-type 2.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TGTCAGATGGGACCACACTTT	0.453000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				10	93					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4228966	4228966	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:4228966C>T	ENST00000379453.4	-	1	755	c.639G>A	c.(637-639)gcG>gcA	p.A213A		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	213					cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	GGATGGCGGCCGCCTTGCGCT	0.687000													4	6					0	0	1	0	0
LRRC3	81543	broad.mit.edu	37	21	45877172	45877172	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:45877172C>T	ENST00000291592.4	+	2	962	c.645C>T	c.(643-645)ttC>ttT	p.F215F		NM_030891.3	NP_112153.1	Q9BY71	LRRC3_HUMAN	leucine rich repeat containing 3	215						integral to membrane	protein binding			endometrium(2)|kidney(1)|lung(1)|urinary_tract(1)	5		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		TCGGCTGGTTCGCCATGGTGA	0.642000													8	82					0	0	1	0	0
HGSNAT	138050	broad.mit.edu	37	8	43054643	43054643	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:43054643C>T	ENST00000458501.2	+	18	1923	c.1923C>T	c.(1921-1923)atC>atT	p.I641I	HGSNAT_ENST00000521576.1_Silent_p.I330I|HGSNAT_ENST00000297798.7_Silent_p.I345I|HGSNAT_ENST00000379644.4_Silent_p.I613I			Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	641					lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(6)	13	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			CTCAGAACATCGTCGCCACTG	0.498000													8	22					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13720097	13720097	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:13720097C>T	ENST00000279593.3	-	12	2669	c.2460G>A	c.(2458-2460)ggG>ggA	p.G820G		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	820					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTAGAAGACCCCTGCCATGT	0.512000													20	74					0	0	1	0	0
VDR	7421	broad.mit.edu	37	12	48240510	48240510	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48240510G>A	ENST00000229022.3	-	9	1118	c.837C>T	c.(835-837)ttC>ttT	p.F279F	VDR_ENST00000535672.1_Silent_p.F247F|VDR_ENST00000550325.1_Silent_p.F329F|VDR_ENST00000395324.2_Silent_p.F279F|VDR_ENST00000549336.1_Silent_p.F279F	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	279	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CGTCCATGGTGAAGGACTCAT	0.552000													27	64					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31712394	31712394	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:31712394G>A	ENST00000396556.2	-	9	1930	c.1808C>T	c.(1807-1809)cCg>cTg	p.P603L	OSBPL10_ENST00000438237.2_Missense_Mutation_p.P539L	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	603					lipid transport		lipid binding	p.P603L(2)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		CTCCACCCACGGGATGGTGAG	0.567000													7	86					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42728211	42728211	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:42728211C>T	ENST00000287777.4	+	1	1201	c.1101C>T	c.(1099-1101)ctC>ctT	p.L367L		NM_152393.2	NP_689606.2			kelch-like family member 40																		CTGGAGGCCTCTTCTACAACG	0.582000													7	47					0	0	1	0	0
CACNG8	59283	broad.mit.edu	37	19	54466657	54466657	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54466657C>T	ENST00000270458.2	+	1	364	c.261C>T	c.(259-261)ctC>ctT	p.L87L		NM_031895.5	NP_114101.4	Q8WXS5	CCG8_HUMAN	calcium channel, voltage-dependent, gamma subunit 8	87					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			kidney(1)|large_intestine(3)|lung(8)|urinary_tract(1)	13	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		ACTCGGGCCTCTGGAGGATCT	0.771000													4	15					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44974582	44974582	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:44974582C>T	ENST00000340446.4	-	1	1900	c.1609G>A	c.(1609-1611)Gaa>Aaa	p.E537K		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	537	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		GCAGGAGTTTCATCTGCAGGA	0.488000													20	29					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43496117	43496117	+	Translation_Start_Site	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:43496117A>T	ENST00000400427.1	+	0	260				UMODL1_ENST00000400424.1_De_novo_Start_OutOfFrame|UMODL1_ENST00000408910.2_Missense_Mutation_p.K27I|UMODL1_ENST00000408989.2_Missense_Mutation_p.K27I	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1							cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CTTTCAGAAAAAGGCCTCTCC	0.567000													74	155					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66462294	66462294	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:66462294G>A	ENST00000404260.3	+	29	7604	c.7296G>A	c.(7294-7296)acG>acA	p.T2432T	MAST4_ENST00000405643.1_Silent_p.T2250T|MAST4_ENST00000403666.1_Silent_p.T2240T|MAST4_ENST00000261569.7_Silent_p.T2235T|MAST4_ENST00000403625.2_Silent_p.T2429T			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	2432						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGCCACCGACGGAGGCAGACA	0.662000											OREG0016638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	8					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176476	140176476	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140176476C>T	ENST00000526136.1	+	1	1927	c.1927C>T	c.(1927-1929)Cct>Tct	p.P643S	PCDHA2_ENST00000378132.1_Missense_Mutation_p.P643S|PCDHA2_ENST00000520672.2_Missense_Mutation_p.P643S|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTGACTCCCCTCGACACCG	0.637000													29	66					0	0	1	0	0
WT1-AS	51352	broad.mit.edu	37	11	32460452	32460452	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:32460452G>A	ENST00000395900.1	+	0	1330				WT1-AS_ENST00000525436.1_RNA|WT1-AS_ENST00000426618.2_RNA|WT1-AS_ENST00000442957.1_RNA	NR_023920.1															endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6						ACAGCCCCTGGAAAACCATGT	0.537000													11	23					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47847945	47847945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:47847945G>A	ENST00000289672.2	-	52	7777	c.7727C>T	c.(7726-7728)tCc>tTc	p.S2576F	C7orf69_ENST00000418326.2_Intron|C7orf69_ENST00000258776.4_Intron	NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2576					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AAGGTGGCCGGAAACTGCATA	0.527000													15	44					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835376	38835376	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38835376C>T	ENST00000449082.2	-	1	125	c.126G>A	c.(124-126)agG>agA	p.R42R		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	42					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCTTCTGCTCCCTATGCTTCT	0.522000													57	143					0	0	1	0	0
ZNF555	148254	broad.mit.edu	37	19	2852691	2852691	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2852691C>T	ENST00000334241.4	+	4	766	c.628C>T	c.(628-630)Cct>Tct	p.P210S	AC006130.3_ENST00000589365.1_RNA|ZNF555_ENST00000591539.1_Missense_Mutation_p.P209S	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAAACCTTTCCTCGTACTTC	0.448000													40	75					0	0	1	0	0
MS4A6E	245802	broad.mit.edu	37	11	60105304	60105304	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60105304C>T	ENST00000300182.4	+	2	303	c.238C>T	c.(238-240)Cct>Tct	p.P80S		NM_139249.2	NP_640342.1	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member 6E	80						integral to membrane	receptor activity			endometrium(2)|kidney(1)|lung(9)|stomach(1)	13						TGCATTAAATCCTGCCTCATT	0.473000													34	115					0	0	1	0	0
TPD52L1	7164	broad.mit.edu	37	6	125574873	125574873	+	Missense_Mutation	SNP	C	C	T	rs34034771		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:125574873C>T	ENST00000534000.1	+	5	693	c.397C>T	c.(397-399)Cgc>Tgc	p.R133C	TPD52L1_ENST00000392482.2_Intron|TPD52L1_ENST00000530868.1_3'UTR|TPD52L1_ENST00000524679.1_Intron|TPD52L1_ENST00000368388.2_Intron|TPD52L1_ENST00000527711.1_Intron|TPD52L1_ENST00000532429.1_Missense_Mutation_p.R104C|TPD52L1_ENST00000534199.1_Intron|TPD52L1_ENST00000528193.1_Missense_Mutation_p.R133C|TPD52L1_ENST00000304877.13_Missense_Mutation_p.R138C|TPD52L1_ENST00000368402.5_Missense_Mutation_p.R133C	NM_003287.2	NP_003278.1	Q16890	TPD53_HUMAN	tumor protein D52-like 1	133					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|large_intestine(2)|prostate(1)	5			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		TTACTCCATTCGCCATTCCAT	0.299000													33	66					0	0	1	0	0
SPATA31C1	441452	broad.mit.edu	37	9	90535853	90535853	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:90535853C>T	ENST00000602681.1	+	0	1757																											CCCTTTATTTCATCCACACCC	0.567000													68	251					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15480430	15480430	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:15480430G>A	ENST00000217246.4	+	8	978	c.583G>A	c.(583-585)Gag>Aag	p.E195K	MACROD2_ENST00000402914.1_5'UTR|MACROD2_ENST00000310348.4_Missense_Mutation_p.E195K	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	195	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CTTTCCCAACGAGCCTGCTGC	0.443000													22	54					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155287468	155287468	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155287468G>A	ENST00000357232.3	-	5	587	c.588C>T	c.(586-588)atC>atT	p.I196I	DCHS2_ENST00000339452.1_Silent_p.I790I	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	196	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAACATTGATGATCTCGGTGC	0.483000													16	44					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34571961	34571961	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34571961C>T	ENST00000373973.3	+	5	638	c.465C>T	c.(463-465)ttC>ttT	p.F155F	CNBD2_ENST00000538900.1_Silent_p.F155F|CNBD2_ENST00000349339.1_Silent_p.F155F					cyclic nucleotide binding domain containing 2																		GCTTTTATTTCATCTACCTGG	0.522000													22	65					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178418910	178418910	+	Missense_Mutation	SNP	C	C	T	rs17078901		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:178418910C>T	ENST00000231188.5	-	2	857	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	GRM6_ENST00000517717.1_Missense_Mutation_p.E227K	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	227			E -> V (in dbSNP:rs17078898).		detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		ACCCCACTTTCGCCATAGTTG	0.637000													11	28					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127613669	127613669	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:127613669G>A	ENST00000508053.1	-	64	8348	c.7374C>T	c.(7372-7374)aaC>aaT	p.N2458N	FBN2_ENST00000262464.4_Silent_p.N2458N			P35556	FBN2_HUMAN	fibrillin 2	2458	EGF-like 41; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGGTGCAGAGGTTTGGCATTA	0.413000													21	64					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44054630	44054630	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44054630C>T	ENST00000359947.4	+	8	1248	c.908C>T	c.(907-909)tCg>tTg	p.S303L	PTPRF_ENST00000438120.1_Missense_Mutation_p.S303L|PTPRF_ENST00000372414.3_Missense_Mutation_p.S303L|PTPRF_ENST00000372413.3_Missense_Mutation_p.S303L	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	303	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCCATCTCCTCGCTGGGCATG	0.597000													8	25					0	0	1	0	0
ZCCHC24	219654	broad.mit.edu	37	10	81192318	81192318	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:81192318G>A	ENST00000372336.3	-	2	629	c.443C>T	c.(442-444)cCc>cTc	p.P148L	ZCCHC24_ENST00000372333.3_Silent_p.P88P	NM_153367.3	NP_699198.2	Q8N2G6	ZCH24_HUMAN	zinc finger, CCHC domain containing 24	148							nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)	9						CCTTACCTGGGGGCAGTCCTT	0.652000													15	37					0	0	1	0	0
SLC25A11	8402	broad.mit.edu	37	17	4841131	4841131	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:4841131G>A	ENST00000225665.7	-	8	1190	c.850C>T	c.(850-852)Ccg>Tcg	p.P284S	SLC25A11_ENST00000544061.2_Missense_Mutation_p.P233S	NM_001165417.1|NM_003562.4	NP_001158889.1|NP_003553.2	Q02978	M2OM_HUMAN	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	284					gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	10						GCATAGTACGGCGTGAAGCCC	0.592000													21	62					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54922002	54922002	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:54922002C>T	ENST00000474759.1	+	24	2121	c.2073C>T	c.(2071-2073)atC>atT	p.I691I	CACNA2D3_ENST00000415676.2_Silent_p.I691I|CACNA2D3_ENST00000288197.5_Silent_p.I691I|CACNA2D3_ENST00000490478.1_Silent_p.I597I|CACNA2D3-AS1_ENST00000471265.1_RNA	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	691						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AAGAATTGATCCAAGAAGTCC	0.532000													40	62					0	0	1	0	0
MFSD12	126321	broad.mit.edu	37	19	3557246	3557246	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:3557246G>A	ENST00000355415.2	-	1	325	c.156C>T	c.(154-156)gcC>gcT	p.A52A	MFSD12_ENST00000398558.4_Silent_p.A52A|MFSD12_ENST00000389395.3_Silent_p.A52A|MFSD12_ENST00000591878.1_Intron|AC005786.7_ENST00000589360.1_RNA	NM_174983.3	NP_778148.2	Q6NUT3	CS028_HUMAN	major facilitator superfamily domain containing 12	52					transmembrane transport	integral to membrane				cervix(1)|endometrium(2)|lung(4)|urinary_tract(2)	9						GGGAGCTGTAGGCGCGCACCG	0.711000													8	14					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778336	31778336	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31778336C>T	ENST00000375654.4	-	2	1603	c.1414G>A	c.(1414-1416)Gga>Aga	p.G472R	HSPA1L_ENST00000417199.3_Missense_Mutation_p.G472R	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	472					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						TGAGGAACTCCCCTGGGTGCT	0.552000													44	103					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143793092	143793092	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143793092G>A	ENST00000408949.2	+	1	952	c.892G>A	c.(892-894)Ggg>Agg	p.G298R		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					AGAGGTGAAAGGGGCTCTAAA	0.463000													97	200					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24188277	24188277	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:24188277G>A	ENST00000396671.2	-	7	769	c.421C>T	c.(421-423)Cca>Tca	p.P141S	THRB_ENST00000416420.1_Missense_Mutation_p.P141S|THRB_ENST00000280696.5_Missense_Mutation_p.P156S|THRB_ENST00000356447.4_Missense_Mutation_p.P141S	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	141					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	GAATAGGATGGATGGAGATTT	0.358000													23	91					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137726994	137726994	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:137726994G>A	ENST00000371817.3	+	65	5728	c.5314G>A	c.(5314-5316)Gag>Aag	p.E1772K		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1772	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTCCAACGACGAGGAGATGTC	0.657000													14	41					0	0	1	0	0
DDX58	23586	broad.mit.edu	37	9	32493803	32493803	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:32493803G>A	ENST00000379882.1	-	2	401	c.244C>T	c.(244-246)Ctg>Ttg	p.L82L	DDX58_ENST00000542096.1_Silent_p.L56L|DDX58_ENST00000379883.2_Silent_p.L127L|DDX58_ENST00000545044.1_5'UTR|DDX58_ENST00000379868.1_5'UTR			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	127	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CATTCAGACAGATCAGAAATG	0.284000													9	45					0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12976259	12976259	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12976259G>A	ENST00000251472.4	+	15	1807	c.1768G>A	c.(1768-1770)Gac>Aac	p.D590N		NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	590	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CTTCTTCGGAGACACACCAGA	0.587000													21	164					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46729621	46729621	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:46729621C>T	ENST00000318962.4	-	3	352	c.269G>A	c.(268-270)cGa>cAa	p.R90Q	ALS2CL_ENST00000415953.1_Missense_Mutation_p.R90Q	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	90					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GTCAGCACCTCGCAGCAGCAG	0.612000													7	50					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159165961	159165961	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:159165961G>A	ENST00000283233.5	-	9	1407	c.1094C>T	c.(1093-1095)gCt>gTt	p.A365V	CCDC148_ENST00000536771.1_Missense_Mutation_p.A279V|CCDC148_ENST00000409187.1_Missense_Mutation_p.A374V	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	365										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TTTCAGATCAGCACACAATTC	0.403000													25	60					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109740600	109740600	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:109740600G>A	ENST00000369939.3	+	17	2485		c.e17-1		KIAA1324_ENST00000529753.1_Splice_Site|KIAA1324_ENST00000369938.1_Splice_Site	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324						macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		TAATTTGGCAGGGGTGACAAC	0.453000													26	63					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56606836	56606836	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:56606836C>T	ENST00000336078.4	+	6	3464	c.2688C>T	c.(2686-2688)atC>atT	p.I896I	ZNF532_ENST00000591083.1_Silent_p.I896I|ZNF532_ENST00000591808.1_Silent_p.I896I|ZNF532_ENST00000589288.1_Silent_p.I896I|ZNF532_ENST00000591230.1_Silent_p.I896I	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	896					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						ATCCTGGCATCAAGATAGGAG	0.423000													10	117					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50217868	50217868	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:50217868G>A	ENST00000338821.5	-	28	3290	c.3026C>T	c.(3025-3027)aCc>aTc	p.T1009I	ATP9A_ENST00000311637.5_Missense_Mutation_p.T873I|ATP9A_ENST00000402822.1_Missense_Mutation_p.T888I	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	1009					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GAATGACAAGGTGGCGATGAA	0.547000													13	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179632515	179632515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179632515G>A	ENST00000589042.1	-	40	9666	c.9442C>T	c.(9442-9444)Cgc>Tgc	p.R3148C	TTN_ENST00000342992.6_Missense_Mutation_p.R3148C|TTN_ENST00000360870.5_Missense_Mutation_p.R3148C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R3102C|TTN_ENST00000342175.6_Missense_Mutation_p.R3102C|TTN_ENST00000359218.5_Missense_Mutation_p.R3102C|TTN_ENST00000591111.1_Missense_Mutation_p.R3148C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2883							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCGGATGCGAACATCTCTG	0.398000													52	177					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818779	159818779	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159818779C>T	ENST00000497452.1	-	0	517																											CGACTCCAGCCTCTTCGAAGA	0.493000													69	200					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52131148	52131148	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52131148G>A	ENST00000222107.4	-	5	1074	c.936C>T	c.(934-936)ttC>ttT	p.F312F	SIGLEC5_ENST00000429354.3_Silent_p.F312F|SIGLEC5_ENST00000534261.2_Silent_p.F312F|SIGLEC5_ENST00000599649.1_Silent_p.F312F|SIGLEC5_ENST00000570106.2_Silent_p.F312F			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	312	Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CGCGGCAGGTGAAGCCTCCTT	0.572000													33	66					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34077940	34077940	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34077940G>A	ENST00000389232.4	+	66	9416	c.9346G>A	c.(9346-9348)Gac>Aac	p.D3116N	RYR3_ENST00000415757.3_Missense_Mutation_p.D3116N	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3116					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGAAATCAACGACCTGGCCGA	0.552000													29	84					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28654727	28654727	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:28654727G>A	ENST00000280904.6	-	12	2253	c.1810C>T	c.(1810-1812)Cat>Tat	p.H604Y	DSC2_ENST00000251081.6_Missense_Mutation_p.H604Y	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	604	Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GGTGGGCCATGGATAGGCTCA	0.413000													17	37					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20486717	20486717	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20486717G>A	ENST00000573854.1	+	7	1042	c.928G>A	c.(928-930)Ggt>Agt	p.G310S	ACSM2A_ENST00000575690.1_Missense_Mutation_p.G310S|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000219054.6_Missense_Mutation_p.G310S|ACSM2A_ENST00000536134.1_Missense_Mutation_p.G82S|ACSM2A_ENST00000417235.2_Missense_Mutation_p.G231S|ACSM2A_ENST00000396104.2_Missense_Mutation_p.G310S	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	310					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GAGTATGATGGGTGCCCCCAT	0.512000													34	96					0	0	1	0	0
IKBIP	121457	broad.mit.edu	37	12	99007635	99007635	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:99007635G>A	ENST00000342502.2	-	3	1192	c.781C>T	c.(781-783)Cta>Tta	p.L261L	IKBIP_ENST00000420861.1_Silent_p.L155L|IKBIP_ENST00000393042.3_3'UTR	NM_201612.2	NP_963906.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	261					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						TCTAAGCTTAGAAATCTATCT	0.373000													24	97					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135447862	135447862	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:135447862G>A	ENST00000343036.2	+	7	976	c.928G>A	c.(928-930)Ggg>Agg	p.G310R	C9orf171_ENST00000393216.2_Missense_Mutation_p.G274R	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	310										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						CGTGCGCCAGGGGACCCTGCG	0.602000													13	32					0	0	1	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899021	112899021	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:112899021C>T	ENST00000374530.3	+	8	1377	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	AKAP2_ENST00000259318.7_Silent_p.F168F|AKAP2_ENST00000434623.2_Silent_p.F257F|AKAP2_ENST00000374525.1_Silent_p.F257F|AKAP2_ENST00000510514.5_Silent_p.F399F|AKAP2_ENST00000555236.1_Silent_p.F399F|PALM2-AKAP2_ENST00000302798.7_Silent_p.F399F	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		168							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						ATGGAGAGTTCACTCTCACCA	0.577000													17	36					0	0	1	0	0
HIGD1B	51751	broad.mit.edu	37	17	42925370	42925370	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:42925370G>A	ENST00000253410.2	+	0	101				HIGD1B_ENST00000590423.1_Intron|HIGD1B_ENST00000591513.1_Intron|HIGD1B_ENST00000587021.1_De_novo_Start_InFrame	NM_016438.2	NP_057522.1	Q9P298	HIG1B_HUMAN	HIG1 hypoxia inducible domain family, member 1B							integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Prostate(33;0.109)				TCAAGTAGAGGCTGTGTTGGG	0.527000													4	3					0	0	1	0	0
FAM129C	199786	broad.mit.edu	37	19	17652952	17652952	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17652952C>T	ENST00000335393.4	+	11	1409	c.1271C>T	c.(1270-1272)tCa>tTa	p.S424L	FAM129C_ENST00000599164.1_Missense_Mutation_p.S393L|FAM129C_ENST00000600871.1_Missense_Mutation_p.S370L|FAM129C_ENST00000352727.3_Missense_Mutation_p.S424L|FAM129C_ENST00000332386.5_Missense_Mutation_p.S424L|FAM129C_ENST00000300971.2_Missense_Mutation_p.S424L|FAM129C_ENST00000601861.1_Missense_Mutation_p.S393L|FAM129C_ENST00000595684.1_Missense_Mutation_p.S424L|FAM129C_ENST00000599124.1_Missense_Mutation_p.S393L|FAM129C_ENST00000449408.2_Missense_Mutation_p.S150L	NM_173544.4	NP_775815.2	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	424										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						CAGGTTTACTCATTTGGGGAG	0.587000													70	121					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231889	7231889	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:7231889C>T	ENST00000383467.2	+	1	767	c.753C>T	c.(751-753)ctC>ctT	p.L251L		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	251										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CGAGCGAACTCCACCTGCTGT	0.572000													40	97					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9577743	9577743	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9577743G>A	ENST00000301480.4	-	10	2093	c.1880C>T	c.(1879-1881)cCc>cTc	p.P627L		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						ATATTCATAGGGCTTATCTCC	0.393000													46	120					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68661616	68661616	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:68661616G>A	ENST00000423218.2	-	3	266	c.171C>T	c.(169-171)gtC>gtT	p.V57V	ITGA11_ENST00000315757.7_Silent_p.V57V			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	57					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GGGCGCCCACGACCAGCCTGG	0.567000													21	86					0	0	1	0	0
REPIN1	29803	broad.mit.edu	37	7	150069302	150069302	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150069302C>T	ENST00000397281.2	+	4	1461	c.972C>T	c.(970-972)gcC>gcT	p.A324A	REPIN1_ENST00000444957.1_Silent_p.A324A|REPIN1_ENST00000489432.2_Silent_p.A381A|REPIN1_ENST00000479668.1_3'UTR|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000425389.2_Silent_p.A324A|REPIN1_ENST00000540729.1_Silent_p.A324A	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	324					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CCCAGGCCGCCCCCGGCCCGG	0.731000													4	9					0	0	1	0	0
CYP24A1	1591	broad.mit.edu	37	20	52790077	52790077	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:52790077G>A	ENST00000216862.3	-	1	435	c.42C>T	c.(40-42)ttC>ttT	p.F14F	CYP24A1_ENST00000395955.3_Silent_p.F14F	NM_000782.4	NP_000773.2	Q07973	CP24A_HUMAN	cytochrome P450, family 24, subfamily A, polypeptide 1	14					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GCTGCTGCAGGAAGGCGGCAA	0.687000													3	6					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922862	24922862	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:24922862G>A	ENST00000329468.2	+	1	2322	c.1848G>A	c.(1846-1848)aaG>aaA	p.K616K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ACCCGGGAAAGACATCAGTCT	0.458000													39	75					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81239586	81239586	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81239586G>A	ENST00000552864.1	-	4	608	c.406C>T	c.(406-408)Cgc>Tgc	p.R136C		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	136	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						GGAATTATGCGAGAGATATAA	0.473000													20	71					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1903152	1903152	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:1903152C>T	ENST00000358771.4	+	4	1100	c.948C>T	c.(946-948)ctC>ctT	p.L316L	SIRPA_ENST00000400068.3_Silent_p.L316L|SIRPA_ENST00000356025.3_Silent_p.L316L	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	316	Ig-like C1-type 2.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		TGAGCTGGCTCCTGGTGAATG	0.547000													45	73					0	0	1	0	0
OR10J5	127385	broad.mit.edu	37	1	159504872	159504872	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:159504872G>A	ENST00000334857.2	-	1	970	c.926C>T	c.(925-927)tCt>tTt	p.S309F		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					AATCCATTAAGAAATATTTCT	0.388000													16	36					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78032751	78032751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:78032751C>T	ENST00000397545.4	+	9	1439	c.1412C>T	c.(1411-1413)aCc>aTc	p.T471I	CCDC40_ENST00000374876.4_Intron|CCDC40_ENST00000269318.5_Missense_Mutation_p.T471I|CCDC40_ENST00000374877.3_Missense_Mutation_p.T471I	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	471					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTGAGGACACCCGGATTTTA	0.567000													28	68					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	242003063	242003063	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242003063G>A	ENST00000310397.8	+	18	2431	c.2431G>A	c.(2431-2433)Ggg>Agg	p.G811R	SNED1_ENST00000405547.3_Missense_Mutation_p.G811R|SNED1_ENST00000342631.6_Missense_Mutation_p.G811R|SNED1_ENST00000401884.1_Missense_Mutation_p.G811R|AC005237.4_ENST00000458377.1_RNA	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	811	EGF-like 12; calcium-binding (Potential).				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		GAACCTCCCAGGGGCCTATGT	0.627000													3	14					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33891923	33891923	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33891923G>A	ENST00000504830.1	-	1	374	c.39C>T	c.(37-39)tcC>tcT	p.S13S	ADAMTS12_ENST00000352040.3_Silent_p.S13S|ADAMTS12_ENST00000515401.1_Silent_p.S13S	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	13					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GAGCCACCACGGAAAGGTTTG	0.522000										HNSCC(64;0.19)			52	97					0	0	1	0	0
PAK6	56924	broad.mit.edu	37	15	40564524	40564524	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:40564524C>T	ENST00000455577.2	+	6	1870	c.958C>T	c.(958-960)Cct>Tct	p.P320S	PAK6_ENST00000441369.1_Missense_Mutation_p.P320S|PAK6_ENST00000453867.1_Missense_Mutation_p.P320S|PAK6_ENST00000542403.2_Missense_Mutation_p.P320S|RP11-133K1.2_ENST00000558658.1_3'UTR|PAK6_ENST00000260404.4_Missense_Mutation_p.P320S|PAK6_ENST00000560346.1_Missense_Mutation_p.P320S	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	320	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		GACCTTCAGCCCTCTGACCAC	0.687000													51	102					0	0	1	0	0
BAIAP3	8938	broad.mit.edu	37	16	1389508	1389508	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1389508C>T	ENST00000324385.5	+	5	575	c.417C>T	c.(415-417)ctC>ctT	p.L139L	BAIAP3_ENST00000568887.1_Intron|BAIAP3_ENST00000562208.1_Intron|BAIAP3_ENST00000421665.2_Silent_p.L104L|BAIAP3_ENST00000397488.2_Silent_p.L121L|BAIAP3_ENST00000397489.1_Silent_p.L121L|BAIAP3_ENST00000426824.3_Silent_p.L104L	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	139					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				TGGAGATGCTCTACGAGGAGG	0.682000													7	13					0	0	1	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47253785	47253785	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:47253785G>A	ENST00000296861.2	-	2	1036	c.643C>T	c.(643-645)Ccg>Tcg	p.P215S		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	215					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			GAGAAGGACGGGAGTGTGCCA	0.542000													12	60					0	0	1	0	0
SNX29	92017	broad.mit.edu	37	16	12145944	12145944	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:12145944C>T	ENST00000566228.1	+	8	1058	c.989C>T	c.(988-990)tCt>tTt	p.S330F		NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	0	PX.				cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						GATTCCCTGTCTTTGAACGGG	0.468000													44	152					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26176114	26176114	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26176114G>A	ENST00000335473.7	+	9	2410	c.2160G>A	c.(2158-2160)gtG>gtA	p.V720V	MYO18B_ENST00000536101.1_Silent_p.V720V|MYO18B_ENST00000407587.2_Silent_p.V720V	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	720	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TCTCCATGGTGATGTCGCTGG	0.642000													6	17					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150714259	150714259	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150714259C>T	ENST00000605938.1	-	9	2228	c.2153G>A	c.(2152-2154)tGg>tAg	p.W718*	ATG9B_ENST00000377974.2_Nonsense_Mutation_p.W718*|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_Nonsense_Mutation_p.W204*	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	718					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGGGGCGCCAGAGTGGATG	0.652000													9	18					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162762229	162762229	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:162762229C>T	ENST00000375514.5	+	15	2059	c.1772C>T	c.(1771-1773)gCc>gTc	p.A591V	SLC4A10_ENST00000446997.1_Missense_Mutation_p.A610V|SLC4A10_ENST00000272716.5_Missense_Mutation_p.A580V|SLC4A10_ENST00000421911.1_Missense_Mutation_p.A610V|SLC4A10_ENST00000415876.2_Missense_Mutation_p.A580V	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	610					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						ATACTTGTGGCCACAGATGCT	0.433000													37	87					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53070220	53070220	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53070220C>T	ENST00000252244.3	-	7	1372	c.1314G>A	c.(1312-1314)aaG>aaA	p.K438K		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	438	Coil 2.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						TCTTGGCATCCTTGAGGGCAT	0.537000													23	65					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147114176	147114176	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:147114176G>A	ENST00000383075.3	-	3	663	c.151C>T	c.(151-153)Ccc>Tcc	p.P51S	ZIC4_ENST00000484399.1_Missense_Mutation_p.P51S|ZIC4_ENST00000473123.1_Missense_Mutation_p.P51S|ZIC4_ENST00000525172.2_Missense_Mutation_p.P101S|ZIC4_ENST00000425731.3_Missense_Mutation_p.P89S|ZIC4_ENST00000491672.1_Intron	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	51						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						GAGGCCTGGGGAGGCTCCTCG	0.687000													14	25					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50265441	50265441	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50265441G>A	ENST00000246801.3	-	2	301	c.219C>T	c.(217-219)ctC>ctT	p.L73L		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	73							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		AGGACCGTTTGAGGTTCAGGC	0.612000													9	33					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921186	247921186	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247921186G>A	ENST00000408896.2	-	1	796	c.523C>T	c.(523-525)Cat>Tat	p.H175Y		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AAGAAATGATGGATGATATTG	0.478000													6	17					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	93943946	93943946	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93943946C>T	ENST00000553484.1	+	4	645	c.491C>T	c.(490-492)cCt>cTt	p.P164L	UNC79_ENST00000555664.1_Missense_Mutation_p.P164L|UNC79_ENST00000393151.2_Missense_Mutation_p.P164L|UNC79_ENST00000256339.4_5'UTR			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	164						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TGTTTGCTACCTTTTCTCAAT	0.338000													25	57					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207175678	207175678	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:207175678G>A	ENST00000374423.3	+	5	6812	c.6426G>A	c.(6424-6426)aaG>aaA	p.K2142K		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2142							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AGCTTCCAAAGAAAAGAAATT	0.358000													20	71					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113388725	113388725	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113388725C>T	ENST00000228928.7	+	7	1781	c.1602C>T	c.(1600-1602)tcC>tcT	p.S534S	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	534	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						AGCTGGTGTCCACAGCCCTGA	0.612000													21	40					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060071	54060071	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54060071G>A	ENST00000312233.2	-	3	1071	c.505C>T	c.(505-507)Ccc>Tcc	p.P169S		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	169					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						TGAGACAGGGGATAGGGGGGC	0.687000													12	15					0	0	1	0	0
HHLA2	11148	broad.mit.edu	37	3	108076874	108076874	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108076874G>A	ENST00000357759.5	+	6	1283	c.869G>A	c.(868-870)tGg>tAg	p.W290*	HHLA2_ENST00000491820.1_Nonsense_Mutation_p.W290*|HHLA2_ENST00000467562.1_Nonsense_Mutation_p.W226*|HHLA2_ENST00000467761.1_Nonsense_Mutation_p.W290*|HHLA2_ENST00000489514.2_Nonsense_Mutation_p.W290*	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	290	Ig-like V-type 2.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						CGATTCTCATGGAACAAAGAG	0.373000													63	149					0	0	1	0	0
POFUT1	23509	broad.mit.edu	37	20	30797941	30797941	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30797941C>T	ENST00000375749.3	+	2	254	c.192C>T	c.(190-192)acC>acT	p.T64T	POFUT1_ENST00000486717.1_Intron|POFUT1_ENST00000539210.1_Intron|POFUT1_ENST00000375730.3_Silent_p.T64T	NM_015352.1	NP_056167.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	64					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TAAACCGTACCTTGGCTGTCC	0.547000													27	195					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36166615	36166615	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:36166615C>T	ENST00000303965.4	-	11	2583	c.2094G>A	c.(2092-2094)agG>agA	p.R698R		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	698	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						CTGCACAGCTCCTGTTGGATT	0.428000													17	73					0	0	1	0	0
TYK2	7297	broad.mit.edu	37	19	10476376	10476376	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10476376G>A	ENST00000525621.1	-	7	1309	c.828C>T	c.(826-828)ccC>ccT	p.P276P	TYK2_ENST00000529370.1_Silent_p.P276P|TYK2_ENST00000264818.6_Silent_p.P276P|TYK2_ENST00000524462.1_Silent_p.P91P	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	276	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.P276P(1)		breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GGTGGCACACGGGCACACGCT	0.677000													8	22					0	0	1	0	0
ILVBL	10994	broad.mit.edu	37	19	15234287	15234287	+	Missense_Mutation	SNP	G	G	A	rs34470764		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15234287G>A	ENST00000263383.3	-	3	375	c.236C>T	c.(235-237)tCc>tTc	p.S79F	ILVBL_ENST00000531635.1_5'UTR|ILVBL_ENST00000534378.1_5'UTR	NM_006844.3	NP_006835.2	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	79						integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)	26						CAGCAGCGGGGAAATGTGCCC	0.637000													28	67					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113275932	113275932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113275932G>A	ENST00000297405.5	-	61	10042	c.9798C>T	c.(9796-9798)tcC>tcT	p.S3266S	CSMD3_ENST00000352409.3_Silent_p.S3196S|CSMD3_ENST00000343508.3_Silent_p.S3226S|CSMD3_ENST00000455883.2_Silent_p.S3097S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3266	Sushi 25.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAGCAGGGAAGGATAGCTCAT	0.453000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			18	48					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119428057	119428057	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:119428057G>A	ENST00000369429.3	-	8	1116	c.1107C>T	c.(1105-1107)tcC>tcT	p.S369S	TBX15_ENST00000207157.3_Silent_p.S263S			Q96SF7	TBX15_HUMAN	T-box 15	369						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GAGGAGAACAGGATGGAGATA	0.498000													7	19					0	0	1	0	0
ZNF696	79943	broad.mit.edu	37	8	144378516	144378516	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144378516C>T	ENST00000330143.3	+	3	1080	c.671C>T	c.(670-672)gCc>gTc	p.A224V		NM_030895.2	NP_112157.2	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	8	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			AGGTCGGACGCCGCCAAGCAC	0.721000													4	11					0	0	1	0	0
EML3	256364	broad.mit.edu	37	11	62373637	62373637	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:62373637G>A	ENST00000394773.2	-	13	1861	c.1554C>T	c.(1552-1554)ttC>ttT	p.F518F	EML3_ENST00000278845.4_Silent_p.F519F|EML3_ENST00000438258.1_5'UTR|EML3_ENST00000494176.2_Silent_p.F490F|RP11-831H9.3_ENST00000532626.1_RNA|EML3_ENST00000531557.1_Silent_p.F301F|EML3_ENST00000529309.1_Silent_p.F518F	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3	518						cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						GACACAAGGCGAAGATAGAAC	0.637000													31	63					0	0	1	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781930	128781930	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128781930G>A	ENST00000529694.1	+	2	1138	c.762G>A	c.(760-762)caG>caA	p.Q254Q	KCNJ5_ENST00000338350.4_Silent_p.Q254Q|KCNJ5_ENST00000533599.1_Silent_p.Q254Q	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	254					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CCCTGAACCAGACAGACATCA	0.592000													20	131					0	0	1	0	0
CELF6	60677	broad.mit.edu	37	15	72581617	72581617	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:72581617G>A	ENST00000287202.5	-	8	1146	c.892C>T	c.(892-894)Ccg>Tcg	p.P298S	CELF6_ENST00000567083.1_Missense_Mutation_p.P298S|RP11-106M3.3_ENST00000570175.1_RNA|CELF6_ENST00000543764.2_Missense_Mutation_p.P182S|RP11-106M3.2_ENST00000379915.4_RNA|CELF6_ENST00000395258.2_Missense_Mutation_p.P185S|CELF6_ENST00000539635.1_Missense_Mutation_p.P159S	NM_052840.4	NP_443072.3	Q96J87	CELF6_HUMAN	CUGBP, Elav-like family member 6	298					mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(2)	13						CTGCCAGGCGGGGAGTTGGCT	0.731000													5	8					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83348509	83348509	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:83348509G>A	ENST00000261722.3	-	10	1361	c.1154C>T	c.(1153-1155)aCc>aTc	p.T385I	AP3B2_ENST00000535359.1_Missense_Mutation_p.T385I|RP11-752G15.3_ENST00000560650.1_RNA|AP3B2_ENST00000535348.1_Missense_Mutation_p.T353I	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	385					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGTGGGGTCGGTGGACCTGAT	0.577000													29	48					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92999147	92999147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:92999147C>T	ENST00000523629.1	-	8	1499	c.1045G>A	c.(1045-1047)Gaa>Aaa	p.E349K	RUNX1T1_ENST00000436581.2_Missense_Mutation_p.E360K|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.E312K|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.E322K|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.E312K|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.E349K|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.E312K|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.E322K	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	349	Important for oligomerization.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCTGCCCATTCTCTGTCTGTT	0.383000													43	113					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4409622	4409622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4409622C>T	ENST00000301280.5	+	3	927	c.826C>T	c.(826-828)Ccc>Tcc	p.P276S		NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	276	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAATCTTTCCCCGAAGAAGA	0.592000								Chromatin Structure					20	51					0	0	1	0	0
OVOL1	5017	broad.mit.edu	37	11	65562597	65562597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65562597C>T	ENST00000335987.3	+	4	941	c.589C>T	c.(589-591)Cat>Tat	p.H197Y	OVOL1_ENST00000532448.1_Missense_Mutation_p.H135Y	NM_004561.3	NP_004552.2	O14753	OVOL1_HUMAN	ovo-like zinc finger 1	197					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	6				READ - Rectum adenocarcinoma(159;0.17)		CAAGAAGATCCATGGTGTGCA	0.627000													13	57					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79067090	79067090	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79067090G>A	ENST00000388820.4	-	12	1962	c.1752C>T	c.(1750-1752)ttC>ttT	p.F584F	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	584	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						TGCAGAGGCGGAAGCGCTTGC	0.637000													16	70					0	0	1	0	0
RAMP1	10267	broad.mit.edu	37	2	238820283	238820283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:238820283G>A	ENST00000254661.4	+	3	437	c.305G>A	c.(304-306)aGg>aAg	p.R102K	RAMP1_ENST00000409726.1_Missense_Mutation_p.R80K|RAMP1_ENST00000403885.1_Missense_Mutation_p.R80K|RAMP1_ENST00000404910.2_Missense_Mutation_p.R80K	NM_005855.2	NP_005846.1	O60894	RAMP1_HUMAN	receptor (G protein-coupled) activity modifying protein 1	102					intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity			kidney(1)|large_intestine(1)|lung(2)	4		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	CGCTACTTCAGGAGCTGCCCC	0.657000													18	40					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53413751	53413751	+	Splice_Site	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:53413751T>C	ENST00000371514.3	+	3	366	c.199_splice	c.e3+1	p.F66_splice	SCP2_ENST00000528311.1_5'UTR|SCP2_ENST00000407246.2_Intron|SCP2_ENST00000371509.4_Splice_Site_p.F66_splice|SCP2_ENST00000371513.5_Splice_Site_p.F66_splice	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	66					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						GCTATGTTTTTGGTATGTATT	0.353000													37	139					0	0	1	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89476608	89476608	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:89476608G>A	ENST00000484817.1	-	0	36																											TGAGCAAGGAGCCTCATTGTG	0.552000													4	27					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1537698	1537698	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1537698C>T	ENST00000447419.2	-	2	440	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	PTX4_ENST00000293922.1_Missense_Mutation_p.E134K|PTX4_ENST00000440447.2_Intron			Q96A99	PTX4_HUMAN	pentraxin 4, long	139						extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						GCCTTCCTTTCCCGGGCCCGC	0.706000													18	40					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30202521	30202521	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:30202521G>A	ENST00000397771.2	-	12	1215	c.1038C>T	c.(1036-1038)ttC>ttT	p.F346F	ASCC2_ENST00000542393.1_Silent_p.F270F|ASCC2_ENST00000478812.1_5'UTR|ASCC2_ENST00000307790.3_Silent_p.F346F			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			ACTCTTCGATGAAGCCCTGAA	0.552000													12	30					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117232171	117232171	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:117232171C>T	ENST00000003084.6	+	14	2082	c.1950C>T	c.(1948-1950)ttC>ttT	p.F650F	CFTR_ENST00000454343.1_Silent_p.F589F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	650					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding	p.F650F(1)		NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GTGATTCTTTCGACCAATTTA	0.383000									Cystic Fibrosis				14	92					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21742337	21742337	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21742337G>A	ENST00000328843.6	+	38	6242	c.6211G>A	c.(6211-6213)Gac>Aac	p.D2071N	DNAH11_ENST00000409508.3_Missense_Mutation_p.D2064N			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2071	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GGATCATTACGACTGGGGACT	0.383000									Kartagener syndrome				10	26					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50195622	50195622	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:50195622C>T	ENST00000392518.4	+	3	485	c.113C>T	c.(112-114)tCc>tTc	p.S38F	CPT1C_ENST00000323446.5_Missense_Mutation_p.S38F|CPT1C_ENST00000598293.1_Missense_Mutation_p.S38F|CPT1C_ENST00000354199.5_Missense_Mutation_p.S38F|CPT1C_ENST00000405931.2_Missense_Mutation_p.S38F|CPT1C_ENST00000598714.1_3'UTR	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	38					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GGCCTGCGCTCCTGGAAAAGG	0.617000													15	28					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24805461	24805461	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24805461G>A	ENST00000216274.5	-	10	1695	c.1477C>T	c.(1477-1479)Cca>Tca	p.P493S	RP11-934B9.3_ENST00000555591.1_Intron	NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	493					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		GAACCTACTGGTGGGGGGTGC	0.547000													9	92					0	0	1	0	0
LPCAT4	254531	broad.mit.edu	37	15	34656261	34656261	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:34656261G>A	ENST00000314891.6	-	5	782	c.605C>T	c.(604-606)cCt>cTt	p.P202L		NM_153613.2	NP_705841.2	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	202					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding			NS(1)|breast(1)|large_intestine(2)|lung(5)|prostate(1)	10						GGTGCCCTCAGGAAAGAATAG	0.458000													51	132					0	0	1	0	0
SEPT2	4735	broad.mit.edu	37	2	242285635	242285635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:242285635C>T	ENST00000391973.2	+	10	1425	c.897C>T	c.(895-897)ttC>ttT	p.F299F	SEPT2_ENST00000407971.1_Silent_p.F259F|SEPT2_ENST00000402092.2_Silent_p.F299F|SEPT2_ENST00000391971.2_Silent_p.F299F|SEPT2_ENST00000401990.1_Silent_p.F309F|SEPT2_ENST00000360051.3_Silent_p.F299F	NM_006155.1	NP_006146.1	Q15019	SEPT2_HUMAN	septin 2	299					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)	12		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		ATGAAAACTTCCGTTCTGAGA	0.507000													11	62					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86114835	86114835	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:86114835C>T	ENST00000383699.3	+	9	1678	c.1051C>T	c.(1051-1053)Ctg>Ttg	p.L351L	CADM2_ENST00000407528.2_Silent_p.L382L|CADM2_ENST00000405615.2_Silent_p.L384L	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	382					adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ATTTGTCACGCTGTGTTCTAT	0.423000													12	64					0	0	1	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19209673	19209673	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19209673G>A	ENST00000375341.3	-	7	880	c.623C>T	c.(622-624)tCg>tTg	p.S208L	ALDH4A1_ENST00000538839.1_Missense_Mutation_p.S208L|ALDH4A1_ENST00000538309.1_Missense_Mutation_p.S148L|ALDH4A1_ENST00000454547.1_5'UTR|ALDH4A1_ENST00000290597.5_Missense_Mutation_p.S208L|RP13-279N23.2_ENST00000494072.3_3'UTR	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	208					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	GTTAAAGGGCGAGATGGCCGC	0.672000													32	65					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48613161	48613161	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48613161G>A	ENST00000328333.8	-	72	5984	c.5877C>T	c.(5875-5877)atC>atT	p.I1959I	COL7A1_ENST00000454817.1_Silent_p.I1927I	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1959	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGTCTCCACGATCTCCCGCA	0.682000													29	65					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124982286	124982286	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124982286C>T	ENST00000522917.1	+	6	602	c.396C>T	c.(394-396)ttC>ttT	p.F132F	FER1L6_ENST00000399018.1_Silent_p.F132F	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	132	C2 1.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACTTTGTCTTCGACTTCATTG	0.413000													28	75					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102667464	102667464	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102667464G>A	ENST00000315274.6	-	4	623	c.556C>T	c.(556-558)Caa>Taa	p.Q186*	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	186	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		GGGCCTGGTTGAAAAGCATGA	0.418000													29	67					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29230635	29230635	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29230635C>T	ENST00000441381.1	+	0	79																											AAACAGGTCCCAAATGCTTTT	0.428000													39	80					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112043097	112043097	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:112043097G>A	ENST00000241356.4	-	2	837	c.432C>T	c.(430-432)acC>acT	p.T144T	ADORA3_ENST00000369716.4_Intron|ADORA3_ENST00000369717.4_Intron	NM_000677.3	NP_000668.1	P33765	AA3R_HUMAN	adenosine A3 receptor	144					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|skin(1)	12		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	CAAACATGGGGGTCAATCCCA	0.488000													45	112					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102221052	102221052	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102221052T>A	ENST00000227758.2	+	2	1866	c.467T>A	c.(466-468)cTt>cAt	p.L156H	BIRC2_ENST00000527910.1_3'UTR|BIRC2_ENST00000530675.1_Missense_Mutation_p.L107H|BIRC2_ENST00000532672.1_Missense_Mutation_p.L135H	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	156					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		TACTCCAGCCTTTCTCCAAAC	0.418000													32	150					0	0	1	0	0
GPIHBP1	338328	broad.mit.edu	37	8	144295145	144295145	+	Translation_Start_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:144295145G>A	ENST00000330824.2	+	1	78	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_178172.3	NP_835466.1	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	1					cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity			lung(2)	2	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CCGGCGAGATGAAGGCGCTCG	0.662000													3	7					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48704860	48704860	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:48704860G>A	ENST00000316623.5	-	65	8587	c.8132C>T	c.(8131-8133)tCc>tTc	p.S2711F	FBN1_ENST00000561429.1_5'UTR	NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2711					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGCCTCTGGGGAGAGTGAATT	0.532000													59	144					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67681486	67681486	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67681486G>A	ENST00000334583.6	+	11	1180	c.852G>A	c.(850-852)ggG>ggA	p.G284G	RLTPR_ENST00000545661.1_Silent_p.G284G	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	284										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GCCTCGCGGGGAACCTGCTGG	0.672000													8	5					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94933565	94933565	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94933565C>T	ENST00000337425.5	-	3	911	c.837G>A	c.(835-837)atG>atA	p.M279I	SERPINA9_ENST00000448305.2_Missense_Mutation_p.M181I|SERPINA9_ENST00000424550.2_Missense_Mutation_p.M130I|SERPINA9_ENST00000298845.7_Missense_Mutation_p.M179I|SERPINA9_ENST00000546329.1_Missense_Mutation_p.M243I|SERPINA9_ENST00000380365.3_Missense_Mutation_p.M261I	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	261					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CCTTGTAATCCATCTGCAGCA	0.537000													17	45					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507679	155507679	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155507679C>T	ENST00000302053.3	-	5	980	c.902G>A	c.(901-903)gGa>gAa	p.G301E	FGA_ENST00000403106.3_Missense_Mutation_p.G301E	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	301					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ACTTCCAGGTCCAGAGCTCCC	0.577000													53	145					0	0	1	0	0
NRL	4901	broad.mit.edu	37	14	24552051	24552051	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:24552051G>A	ENST00000561028.1	-	2	326	c.7C>T	c.(7-9)Ctg>Ttg	p.L3L	NRL_ENST00000396997.1_Silent_p.L3L|NRL_ENST00000397002.2_Silent_p.L3L			P54845	NRL_HUMAN	neural retina leucine zipper	3					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding			lung(2)	2				GBM - Glioblastoma multiforme(265;0.0181)		CTGGGGGGCAGGGCCATTCTG	0.602000													11	45					0	0	1	0	0
CARD9	64170	broad.mit.edu	37	9	139264207	139264207	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139264207C>T	ENST00000371732.5	-	7	1237	c.1072G>A	c.(1072-1074)Gac>Aac	p.D358N	CARD9_ENST00000371734.3_Missense_Mutation_p.D358N|CARD9_ENST00000315908.7_Missense_Mutation_p.D358N	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	358					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		CCCACCTGGTCCCGCTCAATG	0.612000													4	5					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150844496	150844496	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:150844496G>A	ENST00000370357.4	+	16	2448	c.2203G>A	c.(2203-2205)Gga>Aga	p.G735R		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	735						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGTCGAGGGACCTCCTGA	0.527000													80	57					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36228084	36228084	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36228084C>T	ENST00000222270.7	+	33	7470	c.7470C>T	c.(7468-7470)ttC>ttT	p.F2490F	WBP7_ENST00000420124.1_Silent_p.F2490F|KMT2B_ENST00000607650.1_RNA	NM_014727.1	NP_055542.1																					ACTATAAGTTCCGTTACCACC	0.632000													5	7					0	0	1	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16855835	16855835	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:16855835G>A	ENST00000261652.2	-	2	136	c.124C>T	c.(124-126)Cct>Tct	p.P42S	TNFRSF13B_ENST00000579315.1_Missense_Mutation_p.P42S|TNFRSF13B_ENST00000581616.2_5'UTR|TNFRSF13B_ENST00000437538.2_Intron|TNFRSF13B_ENST00000583789.1_Intron	NM_012452.2	NP_036584.1	O14836	TR13B_HUMAN	tumor necrosis factor receptor superfamily, member 13B	42					cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|skin(1)	16						CCCAGCAGAGGATCCCAGTAC	0.617000									IgA Deficiency, Selective				19	25					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89619494	89619494	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:89619494C>T	ENST00000268704.2	+	14	1902	c.1887C>T	c.(1885-1887)gcC>gcT	p.A629A		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	629					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		TGTGCATGGCCCTGGGAGGAC	0.622000													8	26					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	404911	404911	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:404911C>T	ENST00000399788.2	-	26	4645	c.4283G>A	c.(4282-4284)cGa>cAa	p.R1428Q	KDM5A_ENST00000382815.4_Missense_Mutation_p.R1428Q	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1428					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						TTCCAAACTTCGGGGCACCAA	0.448000			T	NUP98	AML								58	119					0	0	1	0	0
GH2	2689	broad.mit.edu	37	17	61957617	61957617	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:61957617G>A	ENST00000456543.2	-	5	754	c.714C>T	c.(712-714)ctC>ctT	p.L238L	GH2_ENST00000332800.7_3'UTR|GH2_ENST00000449787.2_3'UTR|GH2_ENST00000423893.2_3'UTR			P01242	SOM2_HUMAN	growth hormone 2	0						extracellular region	hormone activity			breast(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	24						GTGGGCACTGGAGTAGCACCT	0.552000													14	28					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872446	51872446	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51872446C>T	ENST00000371497.5	+	2	3336	c.2449C>T	c.(2449-2451)Ccc>Tcc	p.P817S	TSHZ2_ENST00000329613.6_Missense_Mutation_p.P814S|TSHZ2_ENST00000603338.2_Missense_Mutation_p.P814S	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	817					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CTCCAGGGTCCCCCCCATGAA	0.552000													34	82					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89156913	89156913	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:89156913C>T	ENST00000336596.2	+	1	240	c.15C>T	c.(13-15)ctC>ctT	p.L5L	EPHA3_ENST00000452448.2_Silent_p.L5L|EPHA3_ENST00000494014.1_Silent_p.L5L	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	5						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATTGTCAGCTCTCCATCCTCC	0.562000										TSP Lung(6;0.00050)			30	130					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107450550	107450550	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:107450550C>T	ENST00000409382.3	-	3	1606	c.996G>A	c.(994-996)gaG>gaA	p.E332E	ST6GAL2_ENST00000361686.4_Silent_p.E332E|ST6GAL2_ENST00000409087.3_Silent_p.E332E	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	332					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CAACATCTTTCTCATAACCAC	0.388000													35	105					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54305718	54305718	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:54305718C>T	ENST00000545554.1	+	1	618	c.618C>T	c.(616-618)tcC>tcT	p.S206S	UNC13C_ENST00000537900.1_Silent_p.S206S|UNC13C_ENST00000260323.11_Silent_p.S206S			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	206					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGAAAAAATCCTGGGGAATAA	0.438000													39	112					0	0	1	0	0
CCBL1	883	broad.mit.edu	37	9	131607688	131607688	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:131607688G>A	ENST00000436267.2	-	4	428	c.279C>T	c.(277-279)ctC>ctT	p.L93L	CCBL1_ENST00000483599.1_5'UTR|CCBL1_ENST00000320665.6_5'UTR|CCBL1_ENST00000302586.3_5'UTR			Q16773	KAT1_HUMAN	cysteine conjugate-beta lyase, cytoplasmic	0					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	TGGCCATGGCGAGCTGGAGAC	0.627000													7	20					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158596785	158596785	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:158596785C>T	ENST00000368148.3	-	41	5857	c.5677G>A	c.(5677-5679)Gaa>Aaa	p.E1893K	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Missense_Mutation_p.E1890K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1893					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTCTGACTTTCCTCCTGCAAC	0.423000													44	141					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11302032	11302032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:11302032G>A	ENST00000397056.1	+	3	1500	c.1309G>A	c.(1309-1311)Gtc>Atc	p.V437I	HRH1_ENST00000431010.2_Missense_Mutation_p.V437I|HRH1_ENST00000438284.2_Missense_Mutation_p.V437I	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	437					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	CTTCTTCATGGTCATTGCCTT	0.488000													79	240					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79066542	79066542	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79066542G>A	ENST00000388820.4	-	13	2187	c.1977C>T	c.(1975-1977)gcC>gcT	p.A659A	ADAMTS7_ENST00000566303.1_Intron	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	659	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GGTCCCGGCTGGCTCGGACCT	0.662000													5	13					0	0	1	0	0
FAM26E	254228	broad.mit.edu	37	6	116836979	116836979	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:116836979C>T	ENST00000368599.3	+	2	808	c.757C>T	c.(757-759)Cct>Tct	p.P253S	TRAPPC3L_ENST00000368602.3_Intron	NM_153711.2	NP_714922.1	Q8N5C1	FA26E_HUMAN	family with sequence similarity 26, member E	253						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7		all_cancers(87;0.0608)|all_epithelial(87;0.05)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0242)|all cancers(137;0.0419)|OV - Ovarian serous cystadenocarcinoma(136;0.0671)|Epithelial(106;0.212)		GAGGCCAGATCCTTTTCCCAT	0.478000													38	38					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13414658	13414658	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13414658C>T	ENST00000360228.5	-	16	2026	c.2027G>A	c.(2026-2028)gGg>gAg	p.G676E	CACNA1A_ENST00000573710.2_Missense_Mutation_p.G677E	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	677					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AGACTTGATCCCGTCGTACAT	0.557000													121	74					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76024398	76024398	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76024398G>A	ENST00000393004.2	-	5	1371	c.1150C>T	c.(1150-1152)Cga>Tga	p.R384*	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Nonsense_Mutation_p.R384*|FILIP1_ENST00000370020.1_Nonsense_Mutation_p.R285*			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	384										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						ACACGCTTTCGAAGATTTTCC	0.418000													13	156					0	0	1	0	0
GNRHR	2798	broad.mit.edu	37	4	68610309	68610309	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:68610309C>T	ENST00000226413.4	-	2	743	c.719G>A	c.(718-720)cGg>cAg	p.R240Q	RP11-453E17.1_ENST00000502758.1_RNA|RP11-453E17.1_ENST00000500538.2_RNA|GNRHR_ENST00000420975.2_Silent_p.T197T	NM_000406.2	NP_000397.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	240					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	ATGAAGGACCCGTGTCAGGGT	0.418000													14	66					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665966	19665966	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:19665966G>A	ENST00000328041.6	+	12	1482	c.1285G>A	c.(1285-1287)Gat>Aat	p.D429N		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	429						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ggaggacgaggatgatgatga	0.517000													22	68					0	0	1	0	0
PLCXD2	257068	broad.mit.edu	37	3	111427208	111427208	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:111427208G>A	ENST00000393934.3	+	2	1169	c.599G>A	c.(598-600)cGa>cAa	p.R200Q	PLCXD2_ENST00000477665.1_Missense_Mutation_p.R200Q	NM_153268.3	NP_695000.1	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 2	200	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity	p.R200Q(1)		endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)	17						TTGACGCTGCGAACTCTGTGG	0.512000													19	52					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55450996	55450996	+	Silent	SNP	G	G	A	rs147899515		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:55450996G>A	ENST00000446217.1	-	6	1677	c.1275C>T	c.(1273-1275)ttC>ttT	p.F425F	NLRP7_ENST00000592784.1_Silent_p.F397F|NLRP7_ENST00000340844.2_Silent_p.F397F|NLRP7_ENST00000588756.1_Silent_p.F397F|NLRP7_ENST00000448121.2_Silent_p.F397F|NLRP7_ENST00000328092.5_Silent_p.F397F|NLRP7_ENST00000590030.1_Silent_p.F397F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	397	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GGCTGCAGAGGAAACGCAGGA	0.697000													12	22					0	0	1	0	0
ZFAT	57623	broad.mit.edu	37	8	135613910	135613910	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:135613910G>A	ENST00000520727.1	-	7	2315	c.2016C>T	c.(2014-2016)ctC>ctT	p.L672L	ZFAT_ENST00000429442.2_Silent_p.L672L|ZFAT_ENST00000520214.1_Silent_p.L672L|ZFAT_ENST00000520356.1_Silent_p.L672L|ZFAT_ENST00000523399.1_Silent_p.L622L|ZFAT_ENST00000377838.3_Silent_p.L684L	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	684			R -> K (in dbSNP:rs35003767).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTGGAGGGAGGAGGTCTGAGG	0.597000													6	77					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69352210	69352210	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:69352210G>A	ENST00000193403.6	-	12	1700	c.1317C>T	c.(1315-1317)gcC>gcT	p.A439A	ACTN1_ENST00000438964.2_Silent_p.A439A|ACTN1_ENST00000376839.3_Silent_p.A374A|ACTN1_ENST00000538545.2_Silent_p.A439A|ACTN1_ENST00000394419.4_Silent_p.A439A	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	439	Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CACTCTCGAAGGCCTCATGCT	0.617000													12	40					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862608	5862608	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5862608G>A	ENST00000329322.5	-	1	519	c.520C>T	c.(520-522)Cgt>Tgt	p.R174C	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Missense_Mutation_p.R178C	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R178C(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGATGATACGATGTCCACAG	0.478000													39	107					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159166610	159166610	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:159166610C>T	ENST00000297239.9	+	11	1148	c.954C>T	c.(952-954)ttC>ttT	p.F318F	SYTL3_ENST00000360448.3_Silent_p.F250F|SYTL3_ENST00000367081.3_Silent_p.F44F			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	318	C2 1.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		ATTATTGCTTCAAAACCCATT	0.358000													6	14					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216172336	216172336	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:216172336T>C	ENST00000366943.2	-	34	6936	c.6550A>G	c.(6550-6552)Aca>Gca	p.T2184A	USH2A_ENST00000307340.3_Missense_Mutation_p.T2184A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2184	Fibronectin type-III 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAATCATGTGTATGGTTTGAC	0.318000										HNSCC(13;0.011)			29	89					0	0	1	0	0
LDLRAD2	401944	broad.mit.edu	37	1	22140990	22140990	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:22140990C>T	ENST00000344642.2	+	2	372	c.185C>T	c.(184-186)aCc>aTc	p.T62I	LDLRAD2_ENST00000543870.1_Missense_Mutation_p.T62I	NM_001013693.2	NP_001013715.2	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain containing 2	62						integral to membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)	6		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		GCTCCGGACACCGACTGCGGG	0.726000													8	47					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2377216	2377216	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:2377216C>T	ENST00000202625.2	+	4	550	c.489C>T	c.(487-489)atC>atT	p.I163I	TGM6_ENST00000381423.1_Silent_p.I163I|TGM6_ENST00000477505.1_Intron	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	163					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	ACAGCGGCATCATCTTCCGAG	0.617000													17	51					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71036137	71036137	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:71036137G>A	ENST00000452400.2	-	21	4456	c.4275C>T	c.(4273-4275)tcC>tcT	p.S1425S	NCOA2_ENST00000267974.4_Silent_p.S513S	NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1425					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GACCCATGGAGGACAGCCCTG	0.522000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								9	14					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131261477	131261477	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:131261477C>T	ENST00000512055.1	-	19	3589	c.1463G>A	c.(1462-1464)gGg>gAg	p.G488E	CPNE4_ENST00000512332.1_Missense_Mutation_p.G506E|CPNE4_ENST00000502818.1_Missense_Mutation_p.G506E|CPNE4_ENST00000511604.1_Missense_Mutation_p.G488E|CPNE4_ENST00000429747.1_Missense_Mutation_p.G488E			Q96A23	CPNE4_HUMAN	copine IV	488	VWFA.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						CCTCAGAATCCCATCATCACC	0.537000													22	78					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354135	57354135	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:57354135C>T	ENST00000314922.3	-	2	576	c.500G>A	c.(499-501)cGa>cAa	p.R167Q	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Missense_Mutation_p.R167Q	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	167					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCTACGCTCTCGGTTGTCCCC	0.527000													8	136					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3046493	3046493	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:3046493G>A	ENST00000520002.1	-	36	5997	c.5442C>T	c.(5440-5442)atC>atT	p.I1814I	CSMD1_ENST00000542608.1_Silent_p.I1813I|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000539096.1_Silent_p.I1813I|CSMD1_ENST00000537824.1_Silent_p.I1813I|CSMD1_ENST00000602723.1_Silent_p.I1814I|CSMD1_ENST00000400186.3_Silent_p.I1814I|CSMD1_ENST00000602557.1_Silent_p.I1814I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1814	CUB 11.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGGGGGACAGGATTGTACCTC	0.463000													6	20					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68939473	68939473	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:68939473G>A	ENST00000288368.4	+	5	735	c.458G>A	c.(457-459)gGa>gAa	p.G153E	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	153	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						ATGCTGCTTGGAGGACGGAAG	0.348000													29	76					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249484	52249484	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52249484G>A	ENST00000595042.1	-	3	905	c.764C>T	c.(763-765)tCc>tTc	p.S255F	FPR1_ENST00000304748.4_Missense_Mutation_p.S255F	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	255					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CTGATATGGGGACCAGCAGAG	0.498000													15	36					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124404283	124404283	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:124404283G>A	ENST00000303921.2	-	1	1398	c.748C>T	c.(748-750)Ccc>Tcc	p.P250S		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	250						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GGGTAGAAGGGGTTCTTCAGT	0.622000													16	47					0	0	1	0	0
DAW1	164781	broad.mit.edu	37	2	228754612	228754612	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228754612G>A	ENST00000373666.2	+	3	790	c.154G>A	c.(154-156)Gaa>Aaa	p.E52K	DAW1_ENST00000472604.1_3'UTR|DAW1_ENST00000545118.1_Missense_Mutation_p.E37K|DAW1_ENST00000309931.2_Missense_Mutation_p.E52K					dynein assembly factor with WDR repeat domains 1																		CCAGAAGGCAGAACCTCTACT	0.383000													27	65					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140356050	140356050	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:140356050G>A	ENST00000406427.1	-	33	4115	c.3779C>T	c.(3778-3780)tCc>tTc	p.S1260F	PNPLA7_ENST00000492278.1_5'UTR|PNPLA7_ENST00000371457.1_Missense_Mutation_p.S841F|PNPLA7_ENST00000277531.4_Missense_Mutation_p.S1235F	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1235					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GTCCGTGAAGGAGGCGTTGGG	0.652000													8	33					0	0	1	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16734078	16734078	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:16734078C>T	ENST00000297967.5	+	1	178	c.79C>T	c.(79-81)Ctg>Ttg	p.L27L	NLGN4Y_ENST00000476359.1_3'UTR	NM_001164238.1	NP_001157710.1	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked	27					brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity			large_intestine(3)|lung(7)|prostate(2)|skin(2)	14						CAATGTTCTTCTGTGGATAAC	0.458000													16	38					0	0	1	0	0
ZNF812	729648	broad.mit.edu	37	19	9801565	9801565	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9801565G>A	ENST00000457674.2	-	5	1132	c.614C>T	c.(613-615)tCc>tTc	p.S205F	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAGGTGTGAGGAATGAGTGAT	0.368000													12	19					0	0	1	0	0
OR56A4	120793	broad.mit.edu	37	11	6023414	6023414	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:6023414C>T	ENST00000330728.4	-	1	1010	c.965G>A	c.(964-966)aGa>aAa	p.R322K		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGAGGAATTCTCTTCCTGGC	0.532000													15	43					0	0	1	0	0
OR6C76	390326	broad.mit.edu	37	12	55820223	55820223	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:55820223G>A	ENST00000328314.3	+	1	186	c.186G>A	c.(184-186)agG>agA	p.R62R		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						TCTTCCTCAGGAATTTCTCCT	0.393000													56	138					0	0	1	0	0
TDG	6996	broad.mit.edu	37	12	104376924	104376924	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:104376924C>T	ENST00000392872.3	+	6	859	c.625C>T	c.(625-627)Cgt>Tgt	p.R209C	TDG_ENST00000542036.1_Intron|TDG_ENST00000544861.1_Missense_Mutation_p.R66C|TDG_ENST00000266775.9_Missense_Mutation_p.R205C	NM_003211.4	NP_003202.3	Q13569	TDG_HUMAN	thymine-DNA glycosylase	209					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			large_intestine(2)|lung(14)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(302;0.00114)		TAAAGAATTTCGTGAAGGAGG	0.249000								Base excision repair (BER), DNA glycosylases					39	146					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21840889	21840889	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21840889G>T	ENST00000328843.6	+	63	10213	c.10182G>T	c.(10180-10182)gaG>gaT	p.E3394D	DNAH11_ENST00000409508.3_Missense_Mutation_p.E3387D			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3394	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGGAACTTGAGGCAAGTTAAA	0.358000									Kartagener syndrome				3	25					0.150653	0.150664	1	1	0
NPHS1	4868	broad.mit.edu	37	19	36332717	36332717	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36332717G>A	ENST00000378910.5	-	20	2714	c.2715C>T	c.(2713-2715)acC>acT	p.T905T	NPHS1_ENST00000353632.6_Silent_p.T905T	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	905	Ig-like C2-type 8.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGTTGGCAATGGTCAGGAGGC	0.557000													9	21					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256409	63256409	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:63256409G>A	ENST00000323865.3	-	1	1371	c.1138C>T	c.(1138-1140)Ctg>Ttg	p.L380L	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	380					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GCGCCCAACAGGGTGGGCATG	0.527000													69	206					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115395442	115395442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:115395442G>A	ENST00000393780.3	+	3	1189	c.721G>A	c.(721-723)Gct>Act	p.A241T	GAP43_ENST00000305124.6_Missense_Mutation_p.A205T	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	205					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		GAGCAGCCAAGCTGAAGAGAA	0.607000													9	25					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46214590	46214590	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46214590G>A	ENST00000371374.1	-	4	657	c.466C>T	c.(466-468)Ctc>Ttc	p.L156F	RCAN2_ENST00000405162.1_Missense_Mutation_p.L156F|RCAN2_ENST00000330430.6_Missense_Mutation_p.L110F|RCAN2_ENST00000306764.7_Missense_Mutation_p.L156F	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	110					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						GGCGAGATGAGAAACTGTTTG	0.522000													13	55					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26702046	26702046	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26702046G>A	ENST00000529632.2	+	6	1646	c.1450G>A	c.(1450-1452)Gaa>Aaa	p.E484K	SEZ6L_ENST00000343706.4_Missense_Mutation_p.E484K|SEZ6L_ENST00000360929.3_Missense_Mutation_p.E484K|SEZ6L_ENST00000404234.3_Missense_Mutation_p.E484K|SEZ6L_ENST00000248933.6_Missense_Mutation_p.E484K|SEZ6L_ENST00000402979.1_Missense_Mutation_p.E257K|SEZ6L_ENST00000403121.1_Missense_Mutation_p.E257K	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	484	CUB 2.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CTGGACGATTGAAGCTCCAGA	0.552000													26	57					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270553	1270553	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:1270553C>T	ENST00000348261.5	+	35	6869	c.6621C>T	c.(6619-6621)tcC>tcT	p.S2207S	CACNA1H_ENST00000565831.1_Silent_p.S2201S|CACNA1H_ENST00000358590.4_Silent_p.S2201S	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2207					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CGCGGCCCTCCGCGGCAGAGG	0.716000													18	26					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18624986	18624986	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:18624986C>T	ENST00000406451.3	+	3	255	c.105C>T	c.(103-105)ccC>ccT	p.P35P	HDAC9_ENST00000417496.2_Silent_p.P77P|HDAC9_ENST00000441542.2_Silent_p.P35P|HDAC9_ENST00000432645.2_Silent_p.P35P|HDAC9_ENST00000401921.1_Silent_p.P35P|HDAC9_ENST00000406072.1_Silent_p.P63P|HDAC9_ENST00000476135.1_3'UTR|HDAC9_ENST00000428307.2_Silent_p.P35P|HDAC9_ENST00000456174.2_Silent_p.P4P|HDAC9_ENST00000524023.1_Silent_p.P4P|HDAC9_ENST00000405010.3_Silent_p.P35P	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	35					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity	p.P35P(3)|p.P77P(1)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TGATGATGCCCGTGGTGGACC	0.483000													20	150					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	32483453	32483453	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:32483453G>A	ENST00000359872.6	-	1	860	c.99C>T	c.(97-99)ttC>ttT	p.F33F		NM_001094.4	NP_001085.2	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	33					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	GCCCATACACGAAGATGTGGC	0.612000													11	16					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237279	56237279	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56237279C>T	ENST00000312240.2	-	1	735	c.695G>A	c.(694-696)aGg>aAg	p.R232K		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					GGCCTTCTGCCTTCCTTCTGC	0.443000													27	72					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138738756	138738756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:138738756G>A	ENST00000329447.5	-	1	1012	c.748C>T	c.(748-750)Ctc>Ttc	p.L250F	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	250	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CGTTCCGGGAGCGGCGAGCGC	0.677000													9	21					0	0	1	0	0
SERPINC1	462	broad.mit.edu	37	1	173873191	173873191	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:173873191C>T	ENST00000367698.3	-	7	1349	c.1231G>A	c.(1231-1233)Ggc>Agc	p.G411S		NM_000488.3	NP_000479.1	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C (antithrombin), member 1	411					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			NS(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(15)|ovary(1)	25					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GCTTCACTGCCTTCTTCATTT	0.468000													19	70					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241534449	241534449	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241534449C>T	ENST00000391984.2	+	7	1202	c.1006C>T	c.(1006-1008)Ctc>Ttc	p.L336F	CAPN10_ENST00000354082.4_Missense_Mutation_p.L336F|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000391982.2_Missense_Mutation_p.L336F|CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000404753.3_Missense_Mutation_p.L336F	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	336	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		AGAGAGGCTGCTCTGCCATAC	0.637000													18	42					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28534796	28534796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:28534796C>T	ENST00000401766.2	-	12	2116	c.1604G>A	c.(1603-1605)tGg>tAg	p.W535*	SLC6A4_ENST00000261707.3_Nonsense_Mutation_p.W535*			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	535					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CCTCCAGAACCACCCCGGGCT	0.577000													5	41					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19766148	19766148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19766148G>A	ENST00000357324.6	-	11	1537	c.1511C>T	c.(1510-1512)tCc>tTc	p.S504F	ATP13A1_ENST00000291503.5_Missense_Mutation_p.S386F|ATP13A1_ENST00000496082.1_5'UTR	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	504					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGCGATGAGGGAGGTGTTGAC	0.637000													17	46					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197036339	197036339	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197036339G>A	ENST00000367412.1	-	1	58	c.15C>T	c.(13-15)aaC>aaT	p.N5N		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	5					blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TAAAAGTCAGGTTTTTCAACC	0.308000													15	39					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141890	29141890	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:29141890C>T	ENST00000377167.2	+	1	580	c.478C>T	c.(478-480)Cat>Tat	p.H160Y		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H160D(1)		endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CTCAGCACTTCATTCCTCCTT	0.463000													32	265					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111470544	111470544	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:111470544G>A	ENST00000265162.5	+	15	2536	c.2194G>A	c.(2194-2196)Gga>Aga	p.G732R		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	732					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AGATTCTCTGGGATGGAATGA	0.313000													16	76					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61778406	61778406	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:61778406C>T	ENST00000423902.2	+	38	9387	c.8908C>T	c.(8908-8910)Ctc>Ttc	p.L2970F	CHD7_ENST00000524602.1_Missense_Mutation_p.L921F	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2970					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGAGTCCTCCCTCTTAGAAGA	0.488000													8	16					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73149058	73149058	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:73149058C>T	ENST00000286657.4	-	22	3449	c.3413G>A	c.(3412-3414)gGa>gAa	p.G1138E		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	1138					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGTCTTACTTCCTGCTTGCTG	0.512000													47	88					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28273125	28273125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:28273125C>T	ENST00000305242.5	-	5	762	c.670G>A	c.(670-672)Gaa>Aaa	p.E224K	ARMC4_ENST00000239715.3_Missense_Mutation_p.E81K	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	224							binding	p.E224Q(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						GAGGTATATTCAATAGATTCC	0.328000													45	106					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005808	74005808	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74005808C>T	ENST00000301607.3	-	22	3731	c.3478G>A	c.(3478-3480)Gag>Aag	p.E1160K	EVPL_ENST00000586740.1_Missense_Mutation_p.E1182K	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1160	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CTCTCCTCCTCGAGGAGGCTC	0.622000													19	39					0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55056065	55056065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:55056065G>A	ENST00000505374.1	+	4	257	c.165G>A	c.(163-165)atG>atA	p.M55I	DDX4_ENST00000354991.5_Missense_Mutation_p.M55I|SLC38A9_ENST00000504880.1_Intron|DDX4_ENST00000508580.1_3'UTR|DDX4_ENST00000353507.5_Missense_Mutation_p.M55I|DDX4_ENST00000514278.2_Missense_Mutation_p.M55I	NM_024415.2	NP_077726.1	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	55					multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				ATCATTTCATGAAAAGTGGAT	0.358000													41	95					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603410	5603410	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5603410C>T	ENST00000423158.3	+	2	281	c.69C>T	c.(67-69)ctC>ctT	p.L23L	NTF3_ENST00000331010.6_Silent_p.L10L|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	10					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding	p.L10L(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						TGATATTTCTCGCTTATCTCC	0.433000													26	69					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72159743	72159743	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:72159743G>A	ENST00000438125.1	-	0	1053							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										GTGGGCGGTCGATTTTCTTCA	0.388000													27	81					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43075811	43075811	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:43075811G>A	ENST00000267890.6	-	11	1111	c.1003C>T	c.(1003-1005)Cct>Tct	p.P335S	TTBK2_ENST00000567840.1_Missense_Mutation_p.P335S|TTBK2_ENST00000567274.1_Missense_Mutation_p.P300S	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	335					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AAGTCTCCAGGGATGGGAGTA	0.373000													83	191					0	0	1	0	0
TCF12	6938	broad.mit.edu	37	15	57523364	57523364	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57523364C>T	ENST00000537840.1	+	2	171	c.26C>T	c.(25-27)cCc>cTc	p.P9L	TCF12_ENST00000438423.2_Silent_p.S198S|TCF12_ENST00000543579.1_Silent_p.S28S|TCF12_ENST00000333725.5_Silent_p.S198S|TCF12_ENST00000267811.5_Silent_p.S198S|TCF12_ENST00000560764.1_3'UTR|TCF12_ENST00000343827.3_Silent_p.S28S|TCF12_ENST00000557843.1_Silent_p.S198S|TCF12_ENST00000452095.2_Silent_p.S194S			Q99081	HTF4_HUMAN	transcription factor 12	0					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATGCACCATCCCCAAATTCAG	0.343000			T	TEC	extraskeletal myxoid chondrosarcoma								46	125					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166848510	166848510	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:166848510G>A	ENST00000423058.2	-	26	5292	c.5275C>T	c.(5275-5277)Cca>Tca	p.P1759S	SCN1A_ENST00000375405.3_Missense_Mutation_p.P1748S|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000303395.4_Missense_Mutation_p.P1759S|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.P1731S	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1759						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCAACAGATGGGTTCCCACAG	0.463000													87	223					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16276744	16276744	+	Missense_Mutation	SNP	C	C	T	rs72653780		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:16276744C>T	ENST00000205557.7	-	16	2016	c.1987G>A	c.(1987-1989)Ggt>Agt	p.G663S	ABCC6_ENST00000574094.1_Intron	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	663	ABC transporter 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCCACTGGACCGACAACAGCC	0.632000													25	71					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124766906	124766906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124766906C>T	ENST00000306534.3	-	2	807	c.322G>A	c.(322-324)Gac>Aac	p.D108N	ROBO4_ENST00000526899.1_5'UTR|ROBO4_ENST00000533054.1_5'UTR	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	108	Ig-like C2-type 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ACACCCAGGTCTGTGGACAGG	0.672000													12	29					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475273	140475273	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140475273C>T	ENST00000194155.4	+	1	1047	c.899C>T	c.(898-900)tCg>tTg	p.S300L		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		300	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.S300*(1)		NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTGCAAAATCGGGAGAACTG	0.413000													38	73					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67303082	67303082	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:67303082A>T	ENST00000392676.3	-	6	636	c.572T>A	c.(571-573)gTt>gAt	p.V191D	ABCA5_ENST00000392677.2_Missense_Mutation_p.V191D|ABCA5_ENST00000588877.1_Missense_Mutation_p.V191D			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	191					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					CCAAAGAGAAACATTGGTCTT	0.343000													41	87					0	0	1	0	0
TMEM189	387521	broad.mit.edu	37	20	48760118	48760118	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:48760118G>A	ENST00000557021.1	-	2	322	c.162C>T	c.(160-162)ttC>ttT	p.F54F	TMEM189-UBE2V1_ENST00000341698.2_Silent_p.F54F|TMEM189_ENST00000371650.5_Silent_p.F54F|TMEM189_ENST00000371652.4_Silent_p.F54F	NM_199203.2	NP_954673.1			transmembrane protein 189											breast(1)|endometrium(2)|large_intestine(3)|lung(2)	8			BRCA - Breast invasive adenocarcinoma(9;3.02e-07)			CGATGAGGCTGAAGCACAGGA	0.632000													11	14					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115760054	115760054	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:115760054G>A	ENST00000427548.1	-	0	1759							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										TGCTGCGGCTGAAGGTTTTTC	0.403000													8	71					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89402436	89402436	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:89402436C>T	ENST00000439576.2	+	12	6994	c.6620C>T	c.(6619-6621)tCg>tTg	p.S2207L	ACAN_ENST00000559004.1_Missense_Mutation_p.S2207L|ACAN_ENST00000561243.1_Missense_Mutation_p.S2207L|ACAN_ENST00000352105.7_Missense_Mutation_p.S2207L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2207					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGTCACACCTCGCAGCTGGGC	0.592000													40	51					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177146484	177146484	+	Missense_Mutation	SNP	C	C	T	rs144171323		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:177146484C>T	ENST00000296525.3	-	2	318	c.205G>A	c.(205-207)Gca>Aca	p.A69T	ASB5_ENST00000511879.1_5'UTR|ASB5_ENST00000512254.1_Missense_Mutation_p.A16T	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	69					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		GATCGATCTGCCCAGGAACCT	0.343000													29	78					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73746301	73746301	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:73746301G>A	ENST00000200181.3	+	28	3613	c.3426G>A	c.(3424-3426)aaG>aaA	p.K1142K	ITGB4_ENST00000339591.3_Silent_p.K1142K|ITGB4_ENST00000450894.3_Silent_p.K1142K|ITGB4_ENST00000579662.1_Silent_p.K1142K|ITGB4_ENST00000449880.2_Silent_p.K1142K	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1142	Fibronectin type-III 1.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity	p.K1142N(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGTCCAGGAAGATCCATTTCA	0.637000											OREG0024739	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	61					0	0	1	0	0
ZNF418	147686	broad.mit.edu	37	19	58439036	58439036	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58439036G>A	ENST00000396147.1	-	4	804	c.513C>T	c.(511-513)agC>agT	p.S171S	ZNF418_ENST00000425570.3_Silent_p.S192S|ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000599852.1_Silent_p.S86S|ZNF418_ENST00000595830.1_Silent_p.S171S	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		GTAATCCTGAGCTGGGCAAAA	0.478000													34	70					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111540568	111540568	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:111540568C>T	ENST00000428084.1	-	15	1614	c.1342G>A	c.(1342-1344)Gag>Aag	p.E448K	DOCK4_ENST00000437633.1_Missense_Mutation_p.E448K|DOCK4_ENST00000476846.1_5'UTR			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	448	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				GCTGGTGGCTCCCCAGAGCCG	0.453000													9	19					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75136738	75136738	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:75136738G>A	ENST00000356357.4	-	14	2215	c.1700C>T	c.(1699-1701)tCt>tTt	p.S567F	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		TCCTCCTAGAGAGGACTCATA	0.542000													9	113					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10427852	10427852	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:10427852C>T	ENST00000245503.5	-	35	5490	c.5106G>A	c.(5104-5106)gaG>gaA	p.E1702E	MYH2_ENST00000397183.2_Silent_p.E1702E|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1702					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTCTGCTCCTCTCTGTCTGTT	0.577000													43	62					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19480431	19480431	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:19480431G>A	ENST00000375267.2	-	45	6464	c.6461C>T	c.(6460-6462)tCc>tTc	p.S2154F	UBR4_ENST00000375226.2_Missense_Mutation_p.S2154F|UBR4_ENST00000375254.3_Missense_Mutation_p.S2154F|UBR4_ENST00000375217.2_Missense_Mutation_p.S2154F			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2154					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCCACCATTGGAACTGCAGAC	0.493000													34	79					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102869433	102869433	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102869433C>T	ENST00000456098.1	-	2	426	c.208G>A	c.(208-210)Ggc>Agc	p.G70S	IGF1_ENST00000307046.8_Missense_Mutation_p.G70S|IGF1_ENST00000392904.1_Missense_Mutation_p.G70S|IGF1_ENST00000424202.2_Missense_Mutation_p.G54S|IGF1_ENST00000337514.6_Missense_Mutation_p.G70S	NM_001111283.1	NP_001104753.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	70	B.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						AAATAAAAGCCCCTGTCTCCA	0.547000													15	61					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52282435	52282435	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52282435G>A	ENST00000301190.6	+	2	456	c.229G>A	c.(229-231)Gac>Aac	p.D77N	ANKRD33_ENST00000538991.1_5'UTR|ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_5'UTR	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	0										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GAGACGGCTGGACATGTCTGA	0.597000													9	80					0	0	1	0	0
FBXO32	114907	broad.mit.edu	37	8	124553147	124553147	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124553147G>A	ENST00000517956.1	-	1	299	c.108C>T	c.(106-108)gaC>gaT	p.D36D	FBXO32_ENST00000443022.2_Silent_p.D36D	NM_058229.3|NM_148177.2	NP_478136.1|NP_680482.1	Q969P5	FBX32_HUMAN	F-box protein 32	36										autonomic_ganglia(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)|stomach(1)	21	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ACCTGCTGAGGTCGCTCACGA	0.687000													11	25					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	141888811	141888811	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:141888811C>T	ENST00000420921.2	-	3	366	c.278G>A	c.(277-279)aGg>aAg	p.R93K	RNF150_ENST00000507500.1_Missense_Mutation_p.R234K|RNF150_ENST00000379512.2_Missense_Mutation_p.R93K|RNF150_ENST00000306799.3_Intron|RNF150_ENST00000515673.1_Missense_Mutation_p.R234K|RNF150_ENST00000515057.1_5'UTR			Q9ULK6	RN150_HUMAN	ring finger protein 150	234	PA.					integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					ATATCGAAACCTCTGGATGTA	0.378000													30	66					0	0	1	0	0
GNAI2	2771	broad.mit.edu	37	3	50293694	50293694	+	Missense_Mutation	SNP	C	C	T	rs137853226		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50293694C>T	ENST00000313601.6	+	5	919	c.535C>T	c.(535-537)Cgc>Tgc	p.R179C	GNAI2_ENST00000451956.1_Missense_Mutation_p.R142C|GNAI2_ENST00000266027.5_Missense_Mutation_p.R163C|GNAI2_ENST00000440628.1_Missense_Mutation_p.R127C|GNAI2_ENST00000491100.1_3'UTR|GNAI2_ENST00000422163.1_Missense_Mutation_p.R163C|GNAI2_ENST00000536647.1_Missense_Mutation_p.R98C	NM_002070.2	NP_002061.1	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	179					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|liver(2)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		GCTACGGACCCGCGTAAAGAC	0.592000													17	41					0	0	1	0	0
CABS1	85438	broad.mit.edu	37	4	71201257	71201257	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71201257G>A	ENST00000273936.4	+	1	560	c.501G>A	c.(499-501)aaG>aaA	p.K167K		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	167						flagellum	calcium ion binding	p.K167K(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GCACACTAAAGGACAGCAGTG	0.433000													16	49					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127797571	127797571	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:127797571C>T	ENST00000556132.1	-	6	2464	c.1600G>A	c.(1600-1602)Gaa>Aaa	p.E534K	SOGA3_ENST00000481848.2_Missense_Mutation_p.E534K|SOGA3_ENST00000525778.1_Missense_Mutation_p.E534K|SOGA3_ENST00000368268.2_Missense_Mutation_p.E534K|SOGA3_ENST00000465909.2_Missense_Mutation_p.E534K	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	534						integral to membrane											GCGGCTTCTTCCTTAACAAAC	0.403000													34	61					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153655048	153655048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:153655048G>A	ENST00000368680.3	+	5	1718	c.1246G>A	c.(1246-1248)Gag>Aag	p.E416K		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	416					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TATGGATCCCGAGAATGGTGC	0.527000													13	49					0	0	1	0	0
INPP5B	3633	broad.mit.edu	37	1	38330034	38330034	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:38330034C>T	ENST00000373023.2	-	23	2909	c.2816G>A	c.(2815-2817)cGa>cAa	p.R939Q	INPP5B_ENST00000373024.3_Missense_Mutation_p.R859Q|INPP5B_ENST00000373027.1_Missense_Mutation_p.R695Q|INPP5B_ENST00000373026.1_Missense_Mutation_p.R939Q	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	939	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CAGCAGTTCTCGCAAAAACGC	0.398000													5	44					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54784340	54784340	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54784340G>A	ENST00000391748.1	-	2	139	c.12C>T	c.(10-12)atC>atT	p.I4I	LILRB2_ENST00000434421.1_5'UTR|LILRB2_ENST00000391746.1_Silent_p.I4I|LILRB2_ENST00000314446.5_Silent_p.I4I|LILRB2_ENST00000391749.4_Silent_p.I4I	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	4					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGACTGTGACGATGGGGGTCA	0.587000													56	144					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71128715	71128715	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71128715C>T	ENST00000299213.8	-	2	400	c.330G>A	c.(328-330)gaG>gaA	p.E110E		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	110	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						AGGCGTCCTTCTCCAGGTTTT	0.483000													90	107					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110420301	110420301	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110420301G>A	ENST00000378402.5	+	18	1941	c.1837G>A	c.(1837-1839)Gaa>Aaa	p.E613K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	613					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCTTGGTTATGAAGTAGTTGA	0.328000										HNSCC(38;0.096)			16	27					0	0	1	0	0
TBX6	6911	broad.mit.edu	37	16	30100386	30100386	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30100386G>A	ENST00000553607.1	-	3	1192	c.499C>T	c.(499-501)Cgc>Tgc	p.R167C	TBX6_ENST00000279386.2_Missense_Mutation_p.R167C|TBX6_ENST00000395224.2_Missense_Mutation_p.R167C			O95947	TBX6_HUMAN	T-box 6	167					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						TCAGGCAGGCGGGGCTCTGCC	0.632000													9	85					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175365684	175365684	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:175365684G>A	ENST00000367674.1	-	5	1944	c.1236C>T	c.(1234-1236)gcC>gcT	p.A412A	TNR_ENST00000263525.2_Silent_p.A412A	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	412	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ACGTACGGGTGGCCACCTTGG	0.502000													23	60					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248731	20248731	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:20248731G>A	ENST00000315957.4	+	1	331	c.250G>A	c.(250-252)Gac>Aac	p.D84N		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AATGCTCATAGACTTCTTTGT	0.443000													109	276					0	0	1	0	0
NFX1	4799	broad.mit.edu	37	9	33294597	33294597	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:33294597C>T	ENST00000379540.3	+	2	267	c.205C>T	c.(205-207)Cat>Tat	p.H69Y	NFX1_ENST00000379521.4_Missense_Mutation_p.H69Y|NFX1_ENST00000318524.6_Missense_Mutation_p.H69Y	NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	69					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		CTCTGCTGTTCATCAGCATAG	0.458000													45	154					0	0	1	0	0
MYL4	4635	broad.mit.edu	37	17	45299116	45299116	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:45299116G>A	ENST00000354968.1	+	5	510	c.382G>A	c.(382-384)Gag>Aag	p.E128K	MYL4_ENST00000393450.1_Missense_Mutation_p.E128K|MYL4_ENST00000572316.1_Missense_Mutation_p.E128K	NM_001002841.1	NP_001002841.1	P12829	MYL4_HUMAN	myosin, light chain 4, alkali; atrial, embryonic	128					cardiac muscle contraction|muscle filament sliding|muscle organ development|positive regulation of ATPase activity|regulation of the force of heart contraction	A band|cytosol|muscle myosin complex	actin filament binding|actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			endometrium(2)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)	11						CCGCAACAAGGAGCAGGGCAC	0.542000													42	57					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82580687	82580687	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:82580687C>T	ENST00000423517.2	-	6	9554	c.9217G>A	c.(9217-9219)Gga>Aga	p.G3073R	PCLO_ENST00000333891.8_Missense_Mutation_p.G3073R	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3004					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TACTGGGGTCCTGGTGGTGGT	0.463000													5	8					0	0	1	0	0
USP50	373509	broad.mit.edu	37	15	50833302	50833302	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:50833302C>T	ENST00000532404.1	-	4	777	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	USP50_ENST00000530218.1_Intron	NM_203494.4	NP_987090.2	E9PP86	E9PP86_HUMAN	ubiquitin specific peptidase 50	202					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(5)	13				all cancers(107;0.000519)|GBM - Glioblastoma multiforme(94;0.00288)		GTGAAGACTTCGTTCTTGTAG	0.443000													15	36					0	0	1	0	0
GCG	2641	broad.mit.edu	37	2	163003880	163003880	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:163003880C>T	ENST00000418842.2	-	3	491	c.237G>A	c.(235-237)atG>atA	p.M79I	GCG_ENST00000375497.3_Missense_Mutation_p.M79I	NM_002054.4	NP_002045.1	P01275	GLUC_HUMAN	glucagon	79					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(9)	14					Exenatide(DB01276)|Phentolamine(DB00692)	TCTTGGTATTCATCAACCACT	0.413000													68	181					0	0	1	0	0
UCP3	7352	broad.mit.edu	37	11	73715533	73715533	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:73715533G>A	ENST00000314032.4	-	5	1191	c.639C>T	c.(637-639)ctC>ctT	p.L213L	UCP3_ENST00000426995.2_Silent_p.L213L|UCP3_ENST00000348534.4_Intron	NM_003356.3	NP_003347.1	P55916	UCP3_HUMAN	uncoupling protein 3 (mitochondrial, proton carrier)	213					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	12	Breast(11;2.08e-05)					CCTCACCAGTGAGCAGGTGGT	0.582000													16	56					0	0	1	0	0
MAP7D2	256714	broad.mit.edu	37	X	20034416	20034416	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:20034416C>T	ENST00000379651.3	-	10	1335	c.1317G>A	c.(1315-1317)aaG>aaA	p.K439K	MAP7D2_ENST00000443379.3_Silent_p.K394K|MAP7D2_ENST00000379643.5_Silent_p.K480K|MAP7D2_ENST00000452324.3_Silent_p.K387K|MAP7D2_ENST00000543767.1_Silent_p.K324K	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	439										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						cctcctctgcctttcttttca	0.463000													14	10					0	0	1	0	0
FAM151A	338094	broad.mit.edu	37	1	55080462	55080462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:55080462C>T	ENST00000302250.2	-	4	646	c.486G>A	c.(484-486)gaG>gaA	p.E162E	FAM151A_ENST00000371304.2_Silent_p.E162E|ACOT11_ENST00000371316.3_Intron	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	162						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTTTGCCTTCCTCTGTCAGCT	0.557000													15	49					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327383	52327383	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52327383C>T	ENST00000339223.4	+	2	561	c.382C>T	c.(382-384)Ctg>Ttg	p.L128L	FPR3_ENST00000595991.1_Silent_p.L128L	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	128					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TATTTGTGTCCTGCATCCAGC	0.468000													31	63					0	0	1	0	0
FOXN4	121643	broad.mit.edu	37	12	109723224	109723224	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:109723224G>A	ENST00000299162.5	-	8	890	c.786C>T	c.(784-786)tcC>tcT	p.S262S	FOXN4_ENST00000355216.1_Silent_p.S82S	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	262					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						AGCCCTTGCGGGAGGAGCCGC	0.602000													19	53					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56436006	56436006	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56436006C>T	ENST00000588751.1	-	3	431	c.407G>A	c.(406-408)gGa>gAa	p.G136E	NLRP13_ENST00000342929.3_Missense_Mutation_p.G136E			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	136							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ATCTTGGCATCCCTGGGTCTG	0.433000													32	90					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617754	111617754	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:111617754G>A	ENST00000374667.3	-	1	1485	c.457C>T	c.(457-459)Ccg>Tcg	p.P153S		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	153						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						GGGCTGAGCGGAGGGTCGGAG	0.622000													9	42					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79254511	79254511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79254511C>T	ENST00000419573.3	-	28	4071	c.3797G>A	c.(3796-3798)cGa>cAa	p.R1266Q	RASGRF1_ENST00000558480.2_Missense_Mutation_p.R1250Q|RASGRF1_ENST00000394745.3_Missense_Mutation_p.R482Q	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	1268	Ras-GEF.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TGGTTCTATTCGGAGAGAAGA	0.463000													6	23					0	0	1	0	0
THRB	7068	broad.mit.edu	37	3	24164462	24164462	+	Silent	SNP	G	G	A	rs144206187	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:24164462G>A	ENST00000396671.2	-	11	1647	c.1299C>T	c.(1297-1299)gcC>gcT	p.A433A	THRB_ENST00000416420.1_Silent_p.A433A|THRB_ENST00000280696.5_Silent_p.A448A|THRB_ENST00000356447.4_Silent_p.A433A	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	433	Interaction with NR2F6.|Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGGCATGGCAGGCTCCTATCA	0.498000													63	133					0	0	1	0	0
CNTFR	1271	broad.mit.edu	37	9	34557641	34557641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:34557641G>A	ENST00000378980.3	-	6	780	c.487C>T	c.(487-489)Cgc>Tgc	p.R163C	CNTFR_ENST00000351266.4_Missense_Mutation_p.R163C	NM_001207011.1|NM_147164.2	NP_001193940.1|NP_671693.1	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	163	Fibronectin type-III 1.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(4)|skin(1)	15	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		ATGTGGCAGCGGTTCTTGAGG	0.537000													24	62					0	0	1	0	0
NREP	9315	broad.mit.edu	37	5	111066648	111066648	+	Silent	SNP	G	G	A	rs11556173		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:111066648G>A	ENST00000379671.3	-	5	441	c.177C>T	c.(175-177)tcC>tcT	p.S59S	NREP_ENST00000446294.2_Silent_p.S59S|STARD4-AS1_ENST00000513221.1_RNA|NREP_ENST00000509427.1_Silent_p.S59S|NREP_ENST00000453526.2_Silent_p.S59S|NREP_ENST00000257435.7_Silent_p.S59S|NREP_ENST00000508870.1_Silent_p.S59S|NREP_ENST00000509979.1_3'UTR|NREP_ENST00000509025.1_Intron|STARD4-AS1_ENST00000500779.2_RNA|NREP_ENST00000395634.3_Silent_p.S103S|NREP_ENST00000515855.1_3'UTR|NREP_ENST00000447165.2_Silent_p.S59S|NREP_ENST00000455559.2_Silent_p.S59S|NREP_ENST00000450761.2_Silent_p.S59S|NREP_ENST00000507742.1_5'UTR|NREP_ENST00000419114.2_Silent_p.S59S	NM_001142478.1	NP_001135950.1	Q16612	NP311_HUMAN	neuronal regeneration related protein	59						cytoplasm											TGATTCTTGGGGAGCGGAGTT	0.463000													20	107					0	0	1	0	0
STARD6	147323	broad.mit.edu	37	18	51863599	51863599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:51863599G>A	ENST00000581310.1	-	6	536	c.163C>T	c.(163-165)Cca>Tca	p.P55S	STARD6_ENST00000580990.2_5'UTR|STARD6_ENST00000307844.3_Missense_Mutation_p.P55S			P59095	STAR6_HUMAN	StAR-related lipid transfer (START) domain containing 6	55	START.				lipid transport		lipid binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)	8				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		GGTGATTCTGGAATTATCCCT	0.313000													21	64					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90347765	90347765	+	Missense_Mutation	SNP	G	G	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:90347765G>C	ENST00000300060.6	-	5	1294	c.981C>G	c.(979-981)ttC>ttG	p.F327L		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	327	Interaction with HCoV-229E.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GACCAGCAAAGAAGTTAAGGA	0.597000													10	140					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57351663	57351663	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57351663G>A	ENST00000361249.3	+	7	1015	c.919G>A	c.(919-921)Gac>Aac	p.D307N		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	307	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GAGGAAGGATGACATTATGCT	0.403000													21	66					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77377374	77377374	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:77377374C>T	ENST00000451710.3	-	26	4450	c.4213G>A	c.(4213-4215)Gaa>Aaa	p.E1405K	TRPM6_ENST00000376864.4_Missense_Mutation_p.E1405K|TRPM6_ENST00000449912.2_Missense_Mutation_p.E1400K|TRPM6_ENST00000360774.1_Missense_Mutation_p.E1405K|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000361255.3_Missense_Mutation_p.E1400K|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1405					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity	p.E1405K(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TCGTGCTTTTCCTTGGGTTCA	0.512000													25	61					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74018548	74018548	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:74018548G>A	ENST00000301607.3	-	5	805	c.552C>T	c.(550-552)atC>atT	p.I184I	EVPL_ENST00000586740.1_Silent_p.I184I	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	184	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CCTTCTGCAGGATGTTGTGCT	0.682000													8	29					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467511	74467511	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:74467511C>T	ENST00000249842.3	+	2	669	c.312C>T	c.(310-312)gaC>gaT	p.D104D	RP11-665J16.1_ENST00000561647.1_RNA|ISLR_ENST00000395118.1_Silent_p.D104D	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	104					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						AGAGCCTGGACCTCAGCCACA	0.607000													21	64					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155098568	155098568	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:155098568G>A	ENST00000392825.3	+	5	904	c.337G>A	c.(337-339)Gaa>Aaa	p.E113K	GALNT13_ENST00000409237.1_Missense_Mutation_p.E113K	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	113						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						CTACCCTGATGAACTTCCAAA	0.333000													24	41					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56565064	56565064	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56565064G>A	ENST00000390649.3	+	13	3189	c.3189G>A	c.(3187-3189)agG>agA	p.R1063R		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1063						mitochondrion|nucleolus	ATP binding	p.R1063R(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGATCTCGAGGAGCAGACACC	0.572000													13	41					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51411827	51411827	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:51411827T>G	ENST00000319760.6	-	1	621	c.569A>C	c.(568-570)tAc>tCc	p.Y190S		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				GCCTATAAAGTAGGTGTCAGT	0.423000													15	44					0	0	1	0	0
CKMT2	1160	broad.mit.edu	37	5	80550833	80550833	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:80550833G>A	ENST00000424301.2	+	6	707	c.469G>A	c.(469-471)Gag>Aag	p.E157K	CTC-281B15.1_ENST00000512287.1_RNA|CTC-281B15.1_ENST00000505295.1_RNA|CTC-281B15.1_ENST00000500148.2_RNA|CTC-281B15.1_ENST00000501927.2_RNA|CTC-281B15.1_ENST00000503483.2_RNA|CKMT2_ENST00000437669.1_Missense_Mutation_p.E157K|CKMT2_ENST00000254035.4_Missense_Mutation_p.E157K|CTC-281B15.1_ENST00000502041.2_RNA|CTC-281B15.1_ENST00000511495.1_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	157					creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	GCAGTTCGACGAGCATTACGT	0.637000													31	63					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131521956	131521956	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131521956G>A	ENST00000423981.1	+	2	2421	c.2311G>A	c.(2311-2313)Gag>Aag	p.E771K	AMER3_ENST00000321420.4_Missense_Mutation_p.E771K	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GGCCTCTGTGGAGGACCAGCC	0.677000													8	19					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36342177	36342177	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:36342177G>A	ENST00000378910.5	-	3	383	c.384C>T	c.(382-384)atC>atT	p.I128I	NPHS1_ENST00000353632.6_Silent_p.I128I	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	128	Ig-like C2-type 1.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGATGGAGAGGATCACTCTGG	0.642000													17	36					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777046	18777046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:18777046C>T	ENST00000380548.4	+	19	3158	c.2819C>T	c.(2818-2820)tCg>tTg	p.S940L		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	940	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CTCAAGCCCTCGGATGCAGGC	0.652000													12	82					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177249815	177249815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:177249815C>T	ENST00000361539.4	+	8	1815	c.1503C>T	c.(1501-1503)aaC>aaT	p.N501N	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		501						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						CCCTGGAAAACTTTCTTGGGC	0.577000													15	73					0	0	1	0	0
MEP1B	4225	broad.mit.edu	37	18	29782870	29782870	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:29782870G>A	ENST00000269202.6	+	6	312	c.265G>A	c.(265-267)Gga>Aga	p.G89R	MEP1B_ENST00000581447.1_Missense_Mutation_p.G89R	NM_005925.2	NP_005916.2	Q16820	MEP1B_HUMAN	meprin A, beta	89	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GAATGCTAAGGGAGTTATCCT	0.363000													5	19					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135744367	135744367	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:135744367G>A	ENST00000375845.3	-	7	2105	c.2075C>T	c.(2074-2076)cCa>cTa	p.P692L	MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000392915.1_Missense_Mutation_p.P709L|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000358371.4_Missense_Mutation_p.P579L	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		TCTGCCTGATGGAGCCGAACA	0.418000													81	173					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238045810	238045810	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:238045810A>T	ENST00000366570.4	-	12	1693	c.1535T>A	c.(1534-1536)cTt>cAt	p.L512H	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	512					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGTCCCAGAAAGGCCTGCCAC	0.453000													48	116					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25861613	25861613	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:25861613G>A	ENST00000376351.3	+	7	1909	c.1550G>A	c.(1549-1551)cGa>cAa	p.R517Q		NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	517						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						ACGGCTCAACGAATTCCATAT	0.408000													24	143					0	0	1	0	0
CCNYL2	414194	broad.mit.edu	37	10	42928724	42928724	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:42928724G>A	ENST00000483242.3	-	0	776					NR_103829.1				cyclin Y-like 2											breast(2)|endometrium(1)|lung(3)|ovary(1)	7						ATTGTAAGATGAGGCTGGCTG	0.393000													29	58					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75069974	75069974	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:75069974C>T	ENST00000310715.3	-	13	1528	c.1408G>A	c.(1408-1410)Gaa>Aaa	p.E470K	TTC18_ENST00000355577.3_5'UTR|TTC18_ENST00000394865.1_Missense_Mutation_p.E470K|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000401621.2_Missense_Mutation_p.E470K|TTC18_ENST00000493787.1_5'UTR	NM_145170.3	NP_660153.3	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	470							binding	p.E470K(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					AGCTGAATTTCCAACACAATG	0.348000													49	124					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70080324	70080324	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:70080324C>T	ENST00000446444.1	-	1	125	c.117G>A	c.(115-117)atG>atA	p.M39I	RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	39					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						GGATTGTCTTCATATTCATCC	0.443000													99	259					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065373	35065373	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35065373C>T	ENST00000382002.5	-	10	2113	c.1687G>A	c.(1687-1689)Gat>Aat	p.D563N	PRLR_ENST00000513753.1_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.D462N|PRLR_ENST00000511486.1_Missense_Mutation_p.D462N|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000310101.5_3'UTR|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	563					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GCATGTGGATCTGGCACCAAC	0.517000													12	55					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54517740	54517740	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:54517740G>A	ENST00000566473.2	+	8	972	c.972G>A	c.(970-972)atG>atA	p.M324I	ANKFN1_ENST00000318698.2_Missense_Mutation_p.M324I			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	324	Fibronectin type-III.									NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						AAATCATCATGGATAATCTGC	0.448000													19	58					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123456259	123456259	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123456259C>T	ENST00000360772.3	-	9	1098	c.720G>A	c.(718-720)ggG>ggA	p.G240G	MYLK_ENST00000346322.5_Silent_p.G240G|MYLK_ENST00000359169.1_Silent_p.G240G|MYLK_ENST00000475616.1_Silent_p.G240G|MYLK_ENST00000360304.3_Silent_p.G240G			Q15746	MYLK_HUMAN	myosin light chain kinase	240	Ig-like C2-type 2.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCGAGGCCTTCCCCGACCCGT	0.567000													55	106					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26085934	26085934	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:26085934C>T	ENST00000313735.6	-	26	3560	c.3327G>A	c.(3325-3327)caG>caA	p.Q1109Q		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	1109					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGTCCTCGACCTGCTCCTCAT	0.607000													9	12					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179720250	179720250	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179720250C>T	ENST00000420890.2	-	19	3001	c.2884G>A	c.(2884-2886)Gaa>Aaa	p.E962K	CCDC141_ENST00000295723.5_Missense_Mutation_p.E387K	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	387							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CTAACTTTTTCCATTTTCCTT	0.284000													10	33					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113519003	113519003	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:113519003G>A	ENST00000297405.5	-	29	5056	c.4812C>T	c.(4810-4812)ttC>ttT	p.F1604F	CSMD3_ENST00000352409.3_Silent_p.F1604F|CSMD3_ENST00000343508.3_Silent_p.F1564F|CSMD3_ENST00000455883.2_Silent_p.F1500F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1604	CUB 9.					integral to membrane|plasma membrane		p.F1564L(1)|p.F1604L(1)|p.F1604_P1605>LA(1)|p.F1564_P1565>LA(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATGGATGAGGGAAGTTTGGTG	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	70					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7647019	7647019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7647019C>T	ENST00000299492.4	+	8	1111	c.723C>T	c.(721-723)gcC>gcT	p.A241A	PPFIBP2_ENST00000533792.1_Silent_p.A83A|PPFIBP2_ENST00000530181.1_Silent_p.A98A|PPFIBP2_ENST00000528883.1_Silent_p.A129A	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	241					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CTGAAGTCGCCCAGCTGCAAG	0.562000													20	48					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68598372	68598372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68598372C>T	ENST00000570495.1	+	5	1974	c.1682C>T	c.(1681-1683)gCc>gTc	p.A561V	RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.A561V|ZFP90_ENST00000563169.2_Missense_Mutation_p.A561V			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	561					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		TGTGGGAAAGCCTTTAGTCAA	0.438000													29	118					0	0	1	0	0
SPAG8	26206	broad.mit.edu	37	9	35811403	35811403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35811403G>A	ENST00000340291.2	-	2	764	c.640C>T	c.(640-642)Cct>Tct	p.P214S	SPAG8_ENST00000479751.1_5'UTR|SPAG8_ENST00000484764.1_Missense_Mutation_p.P212S|SPAG8_ENST00000396638.2_Missense_Mutation_p.P214S	NM_172312.1	NP_758516.1	Q99932	SPAG8_HUMAN	sperm associated antigen 8	214						acrosomal vesicle|membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			AACCCTGGAGGAATACAGGGG	0.597000													25	118					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42113041	42113041	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42113041C>T	ENST00000457542.2	+	23	2779	c.2493C>T	c.(2491-2493)tcC>tcT	p.S831S	MAPKBP1_ENST00000221214.6_Silent_p.S714S|MAPKBP1_ENST00000260357.7_Silent_p.S670S|MAPKBP1_ENST00000456763.2_Silent_p.S837S|MAPKBP1_ENST00000514566.1_Silent_p.S831S	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	837										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CACAGGAGTCCGTGGGGTTCC	0.572000													11	25					0	0	1	0	0
WDR63	126820	broad.mit.edu	37	1	85570255	85570255	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:85570255C>T	ENST00000294664.6	+	14	1708	c.1528C>T	c.(1528-1530)Caa>Taa	p.Q510*	WDR63_ENST00000326813.8_Nonsense_Mutation_p.Q471*|WDR63_ENST00000370596.1_Nonsense_Mutation_p.Q471*	NM_145172.3	NP_660155.2	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	510										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)	36				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		AATATGCTGTCAACTTGTCAC	0.328000													14	47					0	0	1	0	0
LIPG	9388	broad.mit.edu	37	18	47091816	47091816	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:47091816A>T	ENST00000261292.4	+	2	505	c.227A>T	c.(226-228)gAc>gTc	p.D76V	LIPG_ENST00000427224.2_Missense_Mutation_p.D76V|LIPG_ENST00000577628.1_Missense_Mutation_p.D112V|LIPG_ENST00000580036.1_Missense_Mutation_p.D76V	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	76					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						CCCTTAGAAGACTGCAGTTTC	0.517000													18	60					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189020234	189020234	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:189020234C>T	ENST00000512729.1	-	4	800	c.426G>A	c.(424-426)gtG>gtA	p.V142V	TRIML2_ENST00000536972.1_Silent_p.V192V|TRIML2_ENST00000326754.3_Silent_p.V142V	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	142							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TCTCAAGCTCCACGATGAGCT	0.478000													30	90					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76502909	76502909	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76502909C>T	ENST00000389840.5	-	30	4808	c.4684G>A	c.(4684-4686)Gct>Act	p.A1562T	DNAH17_ENST00000585328.1_Missense_Mutation_p.A1563T					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCTGCCAAAGCCTTTTCACAG	0.542000													40	103					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103202396	103202396	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:103202396G>A	ENST00000424685.2	-	35	5374	c.5215C>T	c.(5215-5217)Ccc>Tcc	p.P1739S	RELN_ENST00000343529.5_Missense_Mutation_p.P1739S|RELN_ENST00000428762.1_Missense_Mutation_p.P1739S			P78509	RELN_HUMAN	reelin	1739					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CGGGTCCTGGGAGAACTAACC	0.433000													7	16					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220500079	220500079	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220500079C>T	ENST00000358055.3	+	13	2345	c.1833C>T	c.(1831-1833)atC>atT	p.I611I	SLC4A3_ENST00000273063.6_Silent_p.I638I|SLC4A3_ENST00000373760.2_Silent_p.I611I|SLC4A3_ENST00000373762.3_Silent_p.I638I|SLC4A3_ENST00000317151.3_Silent_p.I611I			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	611					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCATTGTGATCCCCCCGTCCG	0.612000													25	60					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61669557	61669557	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:61669557C>T	ENST00000381103.2	+	18	2115	c.1630C>T	c.(1630-1632)Cgt>Tgt	p.R544C	KIF2A_ENST00000407818.3_Missense_Mutation_p.R602C|KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000401507.3_Missense_Mutation_p.R564C|KIF2A_ENST00000506857.1_Missense_Mutation_p.R518C	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	564	Kinesin-motor.				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		TGGTGATGTTCGTCCAATAAT	0.418000													9	41					0	0	1	0	0
PACSIN1	29993	broad.mit.edu	37	6	34497596	34497596	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:34497596C>T	ENST00000538621.1	+	6	1011	c.766C>T	c.(766-768)Ctc>Ttc	p.L256F	PACSIN1_ENST00000244458.2_Missense_Mutation_p.L256F|PACSIN1_ENST00000374043.2_Missense_Mutation_p.L214F	NM_001199583.1	NP_001186512.1	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in neurons 1	256					endocytosis		protein kinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	13						CAAACGGCACCTCAACCTGGC	0.582000													6	14					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110452971	110452971	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:110452971T>C	ENST00000378402.5	+	33	4093	c.3989T>C	c.(3988-3990)tTa>tCa	p.L1330S		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1330	IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAGTATGTTTTAGAAGTGACC	0.363000										HNSCC(38;0.096)			28	103					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220348929	220348929	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:220348929C>T	ENST00000312358.7	+	30	6876	c.6744C>T	c.(6742-6744)atC>atT	p.I2248I	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2248	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ATGCTCAGATCATTCAGTCCC	0.687000													32	47					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422971	26422971	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:26422971C>T	ENST00000335473.7	+	43	7281	c.7031C>T	c.(7030-7032)tCg>tTg	p.S2344L	MYO18B_ENST00000536101.1_Missense_Mutation_p.S2344L|MYO18B_ENST00000407587.2_Missense_Mutation_p.S2345L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2344				KS -> LT (in Ref. 5).		nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CCCGAAAAGTCGAAAACCCAA	0.557000													22	91					0	0	1	0	0
SHKBP1	92799	broad.mit.edu	37	19	41083492	41083492	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:41083492C>T	ENST00000291842.5	+	4	265	c.216C>T	c.(214-216)ttC>ttT	p.F72F	SHKBP1_ENST00000600733.1_Silent_p.F72F	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	72	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTACAGTCTTCGCCCCCATCC	0.577000													92	195					0	0	1	0	0
MYO6	4646	broad.mit.edu	37	6	76576248	76576248	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:76576248C>T	ENST00000369981.3	+	17	1959	c.1680C>T	c.(1678-1680)ccC>ccT	p.P560P	MYO6_ENST00000369977.3_Silent_p.P560P|MYO6_ENST00000369985.4_Silent_p.P560P|MYO6_ENST00000369975.1_Silent_p.P560P			Q9UM54	MYO6_HUMAN	myosin VI	560	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		TTCAGATTCCCAGAAAATCTA	0.323000													6	76					0	0	1	0	0
SH2D7	646892	broad.mit.edu	37	15	78393354	78393354	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:78393354G>A	ENST00000328828.5	+	5	759	c.759G>A	c.(757-759)cgG>cgA	p.R253R	SH2D7_ENST00000409568.2_Silent_p.R117R	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	253										endometrium(2)|kidney(2)|lung(3)	7						ACCAGGCACGGCTAGGCTTGG	0.607000													17	56					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120730	94120730	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:94120730C>T	ENST00000369303.4	-	3	505	c.321G>A	c.(319-321)agG>agA	p.R107R	EPHA7_ENST00000369297.1_Silent_p.R107R	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	107						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGTTACAATCCCTCAGGGTGA	0.408000													32	58					0	0	1	0	0
VSTM4	196740	broad.mit.edu	37	10	50315887	50315887	+	Missense_Mutation	SNP	G	G	A	rs11554413		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:50315887G>A	ENST00000332853.3	-	2	232	c.209C>T	c.(208-210)tCc>tTc	p.S70F	VSTM4_ENST00000298454.3_Missense_Mutation_p.S70F	NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	70	Ig-like.					integral to membrane|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						GGCCTCCTGGGAGTCGAAGGA	0.612000													24	58					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107600912	107600912	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107600912G>A	ENST00000393561.1	-	16	2548	c.2364C>T	c.(2362-2364)gcC>gcT	p.A788A	LAMB1_ENST00000222399.6_Silent_p.A764A|LAMB1_ENST00000393560.1_Silent_p.A764A			P07942	LAMB1_HUMAN	laminin, beta 1	764	Laminin EGF-like 6.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTAACAGGGCAGAAATGC	0.488000													5	70					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25023491	25023491	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:25023491C>T	ENST00000400382.1	+	12	1868	c.1113C>T	c.(1111-1113)ccC>ccT	p.P371P	GGT1_ENST00000403838.1_Silent_p.P27P|GGT1_ENST00000404223.1_Silent_p.P27P|GGT1_ENST00000400383.1_Silent_p.P371P|GGT1_ENST00000248923.4_Silent_p.P371P|GGT1_ENST00000406383.2_Silent_p.P371P|GGT1_ENST00000404920.1_Silent_p.P27P|GGT1_ENST00000400380.1_Silent_p.P371P|GGT1_ENST00000404532.1_Silent_p.P27P|GGT1_ENST00000401885.1_Silent_p.P27P|GGT1_ENST00000466310.1_3'UTR			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	371					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding	p.P371P(1)		breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	ACTACAAGCCCGAGTTCTACA	0.622000													17	23					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14724464	14724464	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:14724464G>A	ENST00000253697.3	+	3	696	c.244G>A	c.(244-246)Gaa>Aaa	p.E82K	C3orf20_ENST00000412910.1_Intron|C3orf20_ENST00000435614.1_Intron	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	82						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GGTGCTCATGGAACCCACCTT	0.607000													14	43					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189859501	189859501	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:189859501G>A	ENST00000304636.3	+	20	1569	c.1399G>A	c.(1399-1401)Gat>Aat	p.D467N	COL3A1_ENST00000317840.5_Missense_Mutation_p.D467N	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	467	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AGATGGCAAGGATGGATCACC	0.443000													21	69					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45895188	45895188	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:45895188G>A	ENST00000418234.2	-	8	1843	c.1765C>T	c.(1765-1767)Cca>Tca	p.P589S	PPP1R13L_ENST00000360957.5_Missense_Mutation_p.P589S	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	589	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GCCGGGGGTGGAATGGGAGCT	0.667000													21	34					0	0	1	0	0
OR8J1	219477	broad.mit.edu	37	11	56127844	56127844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:56127844G>A	ENST00000303039.3	+	1	154	c.122G>A	c.(121-123)gGg>gAg	p.G41E		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					ACCATGGCAGGGAACCTGGGC	0.493000													48	122					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150932882	150932882	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:150932882G>A	ENST00000261800.5	-	5	4024	c.4012C>T	c.(4012-4014)Cct>Tct	p.P1338S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1338	Cadherin 11.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding	p.P1338S(1)		NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGGGGCCAAGGGATCCACTCA	0.567000													14	50					0	0	1	0	0
TMEM5	10329	broad.mit.edu	37	12	64202844	64202844	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:64202844G>A	ENST00000537373.1	+	6	1472	c.524G>A	c.(523-525)aGc>aAc	p.S175N	TMEM5-AS1_ENST00000546214.1_RNA|TMEM5_ENST00000261234.6_Missense_Mutation_p.S435N	NM_001278237.1	NP_001265166.1	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	435						integral to plasma membrane				breast(1)|large_intestine(3)|liver(2)|lung(7)|prostate(1)|skin(1)	15		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		ATTTTAGAAAGCTCATTTTTA	0.249000													8	34					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88967948	88967948	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:88967948C>T	ENST00000268679.4	-	2	664	c.268G>A	c.(268-270)Ggg>Agg	p.G90R	CBFA2T3_ENST00000448839.1_Intron|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.G90R|CBFA2T3_ENST00000360302.2_Missense_Mutation_p.G29R|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.G29R	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	90	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).|Pro-rich.|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CGTGTGGCCCCCTGGGATGCG	0.687000			T	RUNX1	AML								11	32					0	0	1	0	0
NR1H3	10062	broad.mit.edu	37	11	47283522	47283522	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47283522C>T	ENST00000467728.1	+	6	2179	c.941C>T	c.(940-942)aCc>aTc	p.T314I	NR1H3_ENST00000405853.3_Missense_Mutation_p.T254I|NR1H3_ENST00000441012.2_Missense_Mutation_p.T314I|NR1H3_ENST00000395397.3_Missense_Mutation_p.T269I|NR1H3_ENST00000407404.1_Missense_Mutation_p.T254I|NR1H3_ENST00000405576.1_Missense_Mutation_p.T209I|NR1H3_ENST00000481889.2_Missense_Mutation_p.T333I|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000527949.1_Missense_Mutation_p.T163I			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	314	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						GAGAGTATCACCTTCCTCAAG	0.507000													66	92					0	0	1	0	0
ZNF713	349075	broad.mit.edu	37	7	55990881	55990881	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55990881C>T	ENST00000429591.2	+	2	113	c.75C>T	c.(73-75)gcC>gcT	p.A25A	ZNF713_ENST00000482436.1_3'UTR|MRPS17_ENST00000426595.1_Silent_p.A25A	NM_182633.1	NP_872439.1	Q8N859	ZN713_HUMAN	zinc finger protein 713	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGGATGTGGCCGTGGACTTCA	0.517000													34	58					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186954305	186954305	+	Missense_Mutation	SNP	C	C	T	rs148975558		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186954305C>T	ENST00000296280.6	-	11	1579	c.1354G>A	c.(1354-1356)Ggg>Agg	p.G452R	MASP1_ENST00000495249.1_Intron|MASP1_ENST00000392472.2_Missense_Mutation_p.G339R|MASP1_ENST00000337774.5_Intron	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	451	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TTTCGGCCCCCAATGATCCTC	0.592000													18	183					0	0	1	0	0
IL6	3569	broad.mit.edu	37	7	22767223	22767223	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:22767223C>T	ENST00000404625.1	+	3	639	c.180C>T	c.(178-180)atC>atT	p.I60I	AC073072.5_ENST00000325042.2_RNA|IL6_ENST00000401651.1_Intron|IL6_ENST00000406575.1_Silent_p.I60I|IL6_ENST00000420258.2_Silent_p.I114I|IL6_ENST00000407492.1_Intron|IL6_ENST00000258743.5_Silent_p.I60I|IL6_ENST00000401630.3_Silent_p.I37I			P05231	IL6_HUMAN	interleukin 6 (interferon, beta 2)	60					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding			breast(1)|endometrium(2)|large_intestine(4)|lung(1)	8					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	TTCGGTACATCCTCGACGGCA	0.592000													23	55					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36158063	36158063	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36158063C>T	ENST00000540320.1	+	46	7598	c.7064C>T	c.(7063-7065)gCt>gTt	p.A2355V	NBEA_ENST00000379939.2_Missense_Mutation_p.A2352V|NBEA_ENST00000310336.4_Missense_Mutation_p.A2355V|NBEA_ENST00000537702.1_Missense_Mutation_p.A148V|NBEA_ENST00000400445.3_Missense_Mutation_p.A2355V			Q8NFP9	NBEA_HUMAN	neurobeachin	2355	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CCCAAGAGAGCTGTGTTTTAT	0.333000													21	92					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124750348	124750348	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124750348C>T	ENST00000397801.1	+	27	4185	c.3993C>T	c.(3991-3993)ttC>ttT	p.F1331F	ROBO3_ENST00000525482.1_3'UTR|ROBO3_ENST00000538940.1_Silent_p.F1309F|ROBO3_ENST00000543966.1_Silent_p.F94F	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1331					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GACCAAGCTTCCTGTCCCGGG	0.662000													7	21					0	0	1	0	0
CD5	921	broad.mit.edu	37	11	60886927	60886927	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60886927G>A	ENST00000347785.3	+	5	851	c.685G>A	c.(685-687)Gaa>Aaa	p.E229K		NM_014207.3	NP_055022.2	P06127	CD5_HUMAN	CD5 molecule	229	SRCR 2.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		GGAGCCACGGGAACACCAGCC	0.557000													20	56					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35753829	35753829	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35753829G>A	ENST00000440995.2	+	24	3419	c.3419G>A	c.(3418-3420)gGa>gAa	p.G1140E	SPEF2_ENST00000356031.3_Missense_Mutation_p.G1145E|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1145					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GACACTCTTGGAATGACAATG	0.512000													30	155					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21074807	21074807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:21074807C>T	ENST00000377122.4	-	28	3310	c.2914G>A	c.(2914-2916)Gag>Aag	p.E972K	NEBL_ENST00000377159.4_Missense_Mutation_p.E194K|NEBL_ENST00000417816.2_Missense_Mutation_p.E228K	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	972	SH3.				regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AAGGAGACCTCGTCTTCATCC	0.502000													50	52					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057962	9057962	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9057962G>A	ENST00000397910.4	-	3	29687	c.29484C>T	c.(29482-29484)tcC>tcT	p.S9828S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9830	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTAGGACAGAGGAATGAGATT	0.458000													26	67					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54782698	54782698	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:54782698G>A	ENST00000391748.1	-	6	1051	c.924C>T	c.(922-924)gcC>gcT	p.A308A	LILRB2_ENST00000434421.1_Silent_p.A192A|LILRB2_ENST00000391746.1_Silent_p.A308A|LILRB2_ENST00000314446.5_Silent_p.A308A|LILRB2_ENST00000391749.4_Silent_p.A308A	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	308	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGTCGCTGGGGGCCGAGCACT	0.647000													24	21					0	0	1	0	0
KCNA10	3744	broad.mit.edu	37	1	111061284	111061284	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:111061284C>T	ENST00000369771.2	-	1	513	c.126G>A	c.(124-126)ggG>ggA	p.G42G		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	42						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		AGGAGCTGCCCCCAGGCCGGC	0.557000													18	37					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100141898	100141898	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:100141898C>T	ENST00000524871.1	+	18	2529	c.2239C>T	c.(2239-2241)Cga>Tga	p.R747*	CNTN5_ENST00000279463.3_Nonsense_Mutation_p.R747*|CNTN5_ENST00000528682.1_Nonsense_Mutation_p.R747*|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Nonsense_Mutation_p.R747*|CNTN5_ENST00000418526.2_Nonsense_Mutation_p.R673*	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	747	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ATATGAATTTCGAGTGGTAGC	0.458000													20	53					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102709877	102709877	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102709877C>T	ENST00000299855.5	-	7	1289	c.1033G>A	c.(1033-1035)Gaa>Aaa	p.E345K		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	345	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CTAGTAACTTCATATGCGGCA	0.388000													36	103					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112534	57112534	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:57112534G>A	ENST00000454682.1	-	3	3061	c.2780C>T	c.(2779-2781)cCt>cTt	p.P927L	NACA_ENST00000393891.4_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000548563.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						GATTCCTTTAGGGGCTGGAGT	0.612000			T	BCL6	NHL								15	32					0	0	1	0	0
U66061.31	0	broad.mit.edu	37	7	142423748	142423748	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142423748G>A	ENST00000506718.1	+	0	756																											GCAAGAACAAGGAGACTCCTC	0.552000													7	21					0	0	1	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32975359	32975359	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:32975359C>T	ENST00000229829.5	-	3	417	c.342G>A	c.(340-342)cgG>cgA	p.R114R	HLA-DOA_ENST00000450833.2_Silent_p.R84R|HLA-DOA_ENST00000495532.1_5'UTR	NM_002119.3	NP_002110.1	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO alpha	114	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	9						GCACGGTCACCCGTGGAGGCA	0.597000													46	86					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424093	125424093	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:125424093C>T	ENST00000373686.1	+	1	249	c.249C>T	c.(247-249)ccC>ccT	p.P83P				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						TGTTCCTCCCCATCTACCTTA	0.493000													9	74					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231112699	231112699	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231112699G>A	ENST00000392045.3	+	8	925	c.811G>A	c.(811-813)Gag>Aag	p.E271K	SP140_ENST00000417495.3_Intron|SP140_ENST00000343805.6_Missense_Mutation_p.E245K|SP140_ENST00000486687.2_Intron|SP140_ENST00000350136.5_Intron|SP140_ENST00000420434.3_Missense_Mutation_p.E271K	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	271					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GAAACAGGGAGAGGAGGAAGG	0.488000													23	121					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104081828	104081828	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104081828G>A	ENST00000265148.3	-	21	2329	c.2240C>T	c.(2239-2241)tCa>tTa	p.S747L	CENPE_ENST00000380026.3_Missense_Mutation_p.S722L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	747					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTCAATTCTGAAAGCAAAAT	0.323000													13	94					0	0	1	0	0
KCNQ4	9132	broad.mit.edu	37	1	41303402	41303402	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:41303402C>T	ENST00000347132.5	+	13	1893	c.1811C>T	c.(1810-1812)cCc>cTc	p.P604L	KCNQ4_ENST00000509682.2_Missense_Mutation_p.P550L|KCNQ4_ENST00000506017.1_3'UTR	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4	604	A-domain (Tetramerization).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			GACAAGGGGCCCTCCGACGCG	0.647000													7	18					0	0	1	0	0
ZNF736	728927	broad.mit.edu	37	7	63796756	63796756	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:63796756C>T	ENST00000355095.4	+	3	445	c.123C>T	c.(121-123)gtC>gtT	p.V41V	ZNF736_ENST00000423484.1_Silent_p.V41V	NM_001170905.1	NP_001164376.1	B4DX44	ZN736_HUMAN	zinc finger protein 736	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|stomach(1)|urinary_tract(1)	9						GAAACCTGGTCTCCTTGGGTG	0.383000													15	52					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833351	24833351	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:24833351C>T	ENST00000376451.2	+	14	4461	c.4201C>T	c.(4201-4203)Ccg>Tcg	p.P1401S	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000376454.3_Missense_Mutation_p.P1718S			Q5T5P2	SKT_HUMAN	KIAA1217	1718					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTTGCTAGTTCCGGATGAAGG	0.512000													25	41					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114293996	114293996	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:114293996G>A	ENST00000393500.3	+	16	1793	c.973G>A	c.(973-975)Gaa>Aaa	p.E325K	FOXP2_ENST00000393498.2_Missense_Mutation_p.E379K|FOXP2_ENST00000393491.3_Missense_Mutation_p.E308K|FOXP2_ENST00000403559.4_Missense_Mutation_p.E417K|FOXP2_ENST00000360232.4_Missense_Mutation_p.E400K|FOXP2_ENST00000408937.3_Missense_Mutation_p.E425K|FOXP2_ENST00000393494.2_Missense_Mutation_p.E400K|FOXP2_ENST00000393489.3_Missense_Mutation_p.E308K|FOXP2_ENST00000350908.4_Missense_Mutation_p.E400K|FOXP2_ENST00000390668.3_Missense_Mutation_p.E424K			O15409	FOXP2_HUMAN	forkhead box P2	400					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						TAAAGAACGCGAACGTCTTCA	0.393000													43	111					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47765425	47765425	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:47765425G>A	ENST00000273857.4	-	4	587	c.588C>T	c.(586-588)ttC>ttT	p.F196F	CORIN_ENST00000502252.1_Silent_p.F129F|CORIN_ENST00000505909.1_Silent_p.F196F|CORIN_ENST00000504584.1_Silent_p.F196F|CORIN_ENST00000508498.1_Silent_p.F57F	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	196	FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TGCACTCAGGGAAGGCGAGGG	0.413000													8	26					0	0	1	0	0
ZFAND4	93550	broad.mit.edu	37	10	46148504	46148504	+	Missense_Mutation	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:46148504A>G	ENST00000344646.5	-	3	403	c.188T>C	c.(187-189)aTt>aCt	p.I63T	ZFAND4_ENST00000374371.2_Missense_Mutation_p.I63T|ZFAND4_ENST00000335258.7_Missense_Mutation_p.I63T|ZFAND4_ENST00000374366.3_5'UTR	NM_001128324.1|NM_174890.2	NP_001121796.1|NP_777550.2	Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	63	Ubiquitin-like.						zinc ion binding										ACAGATGGGAATACCTTAAGG	0.303000													22	71					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140348807	140348807	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140348807C>T	ENST00000289269.5	+	1	2988	c.2456C>T	c.(2455-2457)cCt>cTt	p.P819L	PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		819					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCAGGGCCTTCGGGAGCC	0.522000													15	57					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754281	49754281	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49754281G>A	ENST00000304801.3	-	1	772	c.620C>T	c.(619-621)cCc>cTc	p.P207L		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	207					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					AGCCAGAAAGGGTCTCACTGG	0.433000													46	132					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42584550	42584550	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42584550C>T	ENST00000600245.1	+	2	2447	c.1792C>T	c.(1792-1794)Cgc>Tgc	p.R598C	ZNF574_ENST00000222339.7_Missense_Mutation_p.R688C|ZNF574_ENST00000359044.4_Missense_Mutation_p.R598C			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				GCTCATGCACCGCTACCATCA	0.622000													12	39					0	0	1	0	0
MAB21L1	4081	broad.mit.edu	37	13	36049679	36049679	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:36049679C>T	ENST00000379919.4	-	1	1153	c.597G>A	c.(595-597)cgG>cgA	p.R199R	NBEA_ENST00000540320.1_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000310336.4_Intron|NBEA_ENST00000400445.3_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	199					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CCTCCGCCACCCGGTTGGGTC	0.652000													16	73					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131921984	131921984	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131921984G>A	ENST00000286355.5	-	6	3702	c.1610C>T	c.(1609-1611)gCa>gTa	p.A537V	ADCY8_ENST00000377928.3_Missense_Mutation_p.A537V	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	537					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GAGTTTGTTTGCAATATCCAC	0.468000										HNSCC(32;0.087)			85	157					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84537235	84537235	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:84537235C>T	ENST00000262753.4	-	16	1883	c.1738G>A	c.(1738-1740)Gag>Aag	p.E580K	POF1B_ENST00000373145.3_Missense_Mutation_p.E580K	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	580							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TCTGTTTTCTCAATCACAATA	0.368000													16	14					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116037787	116037787	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116037787C>T	ENST00000603594.1	+	7	1002	c.681C>T	c.(679-681)atC>atT	p.I227I	VWA2_ENST00000392982.3_Silent_p.I227I	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	227						extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GCTCGGCCATCTGCTCCAGCG	0.647000													4	35					0	0	1	0	0
DLL3	10683	broad.mit.edu	37	19	39994806	39994806	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:39994806G>A	ENST00000205143.4	+	5	755	c.748G>A	c.(748-750)Gtc>Atc	p.V250I	DLL3_ENST00000356433.5_Missense_Mutation_p.V250I	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	250					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCTCTGCACGGTCCCTGTCTC	0.667000													22	44					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57411647	57411647	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:57411647G>A	ENST00000543257.1	-	8	1362	c.796C>T	c.(796-798)Ctt>Ttt	p.L266F	C8B_ENST00000371237.4_Missense_Mutation_p.L318F|C8B_ENST00000535057.1_Missense_Mutation_p.L256F	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	318	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ACTCTCTGAAGGAACTCGTAA	0.483000													25	50					0	0	1	0	0
EME1	146956	broad.mit.edu	37	17	48457688	48457688	+	Missense_Mutation	SNP	A	A	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48457688A>C	ENST00000393271.2	+	8	1483	c.1401A>C	c.(1399-1401)gaA>gaC	p.E467D	EME1_ENST00000338165.4_Missense_Mutation_p.E454D|EME1_ENST00000511648.2_Missense_Mutation_p.E467D	NM_001166131.1	NP_001159603.1	Q96AY2	EME1_HUMAN	essential meiotic structure-specific endonuclease 1	454					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding			endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	19	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			TCCGAGATGAAACTACCTTCT	0.547000								Direct reversal of damage;Homologous recombination					3	26					0	0	1	0	0
RPL4	6124	broad.mit.edu	37	15	66795836	66795836	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:66795836G>A	ENST00000307961.6	-	2	127	c.35C>T	c.(34-36)tCc>tTc	p.S12F	RPL4_ENST00000568588.1_5'UTR	NM_000968.3	NP_000959.2	P36578	RL4_HUMAN	ribosomal protein L4	12					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)|urinary_tract(1)	17						CCCCTTTTCGGAGTACACCGA	0.428000													14	57					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36899114	36899114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:36899114C>T	ENST00000301807.6	-	12	2214	c.317G>A	c.(316-318)gGa>gAa	p.G106E	TRANK1_ENST00000429976.2_Missense_Mutation_p.G656E|TRANK1_ENST00000428977.2_Missense_Mutation_p.G106E	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	656					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GACTGCACTTCCTTCAGGCAG	0.582000													17	67					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82815175	82815175	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82815175G>A	ENST00000265077.3	+	7	1615	c.1050G>A	c.(1048-1050)gaG>gaA	p.E350E	VCAN_ENST00000342785.4_Silent_p.E350E|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000512590.2_Silent_p.E302E	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	350	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TAGCTAAAGAGGCTACAACCA	0.373000													35	80					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37363342	37363342	+	Missense_Mutation	SNP	C	C	T	rs113898889		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:37363342C>T	ENST00000361924.2	+	13	2040	c.1666C>T	c.(1666-1668)Cgg>Tgg	p.R556W	GOLGA4_ENST00000444882.1_Intron|GOLGA4_ENST00000356847.4_Missense_Mutation_p.R578W	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	556	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding	p.R556W(1)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						AAATAAACTTCGGGACCTTCA	0.348000													33	60					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32137827	32137827	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:32137827C>T	ENST00000312561.4	+	4	4352	c.3938C>T	c.(3937-3939)tCt>tTt	p.S1313F	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		ATGACAGCATCTTATGAACAA	0.348000													16	77					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4217164	4217164	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:4217164C>T	ENST00000600132.1	+	18	2283	c.2007C>T	c.(2005-2007)acC>acT	p.T669T	ANKRD24_ENST00000318934.4_Silent_p.T669T|ANKRD24_ENST00000262970.5_Silent_p.T759T	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	669										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		TCACAGGGACCACAAACATGG	0.617000													5	12					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887946	9887946	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:9887946C>T	ENST00000306084.6	+	2	1669	c.1470C>T	c.(1468-1470)ttC>ttT	p.F490F	TXNDC2_ENST00000357775.4_Silent_p.F423F|TXNDC2_ENST00000577697.1_3'UTR|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	490	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GACCATTCTTCCATGCCCTGT	0.587000													8	38					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140251067	140251067	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140251067T>C	ENST00000398640.2	+	1	2379	c.2379T>C	c.(2377-2379)aaT>aaC	p.N793N	PCDHA6_ENST00000527624.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGGTCAAATCACCCCGGAC	0.463000													3	15					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34166234	34166234	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34166234C>T	ENST00000373381.4	-	23	3792	c.3616G>A	c.(3616-3618)Gtt>Att	p.V1206I	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.V79I	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1166	CUB 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGCTAAAAACTCCCAGCAAA	0.498000													45	95					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33873829	33873829	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33873829C>T	ENST00000389232.4	+	14	1628	c.1558C>T	c.(1558-1560)Ctc>Ttc	p.L520F	RYR3_ENST00000415757.3_Missense_Mutation_p.L520F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	520					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCTGAACCTCCTCTACAAATT	0.448000													24	75					0	0	1	0	0
SPIDR	23514	broad.mit.edu	37	8	48309146	48309146	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:48309146C>T	ENST00000297423.4	+	6	1120	c.736C>T	c.(736-738)Ccc>Tcc	p.P246S	SPIDR_ENST00000518074.1_Missense_Mutation_p.P186S|SPIDR_ENST00000541342.1_Missense_Mutation_p.P176S|SPIDR_ENST00000521214.1_3'UTR	NM_001080394.2	NP_001073863.1			scaffolding protein involved in DNA repair																		AGCTAAGTTTCCCAGGACTCC	0.353000													80	181					0	0	1	0	0
CRTAM	56253	broad.mit.edu	37	11	122720888	122720888	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:122720888C>T	ENST00000227348.4	+	2	206	c.159C>T	c.(157-159)ccC>ccT	p.P53P		NM_019604.2	NP_062550.2	O95727	CRTAM_HUMAN	cytotoxic and regulatory T cell molecule	53	Ig-like V-type.				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		GGCTGACCCCCTCAGGGTTCA	0.483000													24	81					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754690	49754690	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49754690G>A	ENST00000304801.3	-	1	363	c.211C>T	c.(211-213)Ccc>Tcc	p.P71S		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	71					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TCAGGCATGGGAACACCATCA	0.502000													21	102					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32232418	32232418	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:32232418C>T	ENST00000346541.3	+	12	2318	c.1781C>T	c.(1780-1782)gCt>gTt	p.A594V	CBFA2T2_ENST00000543126.1_Missense_Mutation_p.A142V|CBFA2T2_ENST00000359606.3_Missense_Mutation_p.A604V|CBFA2T2_ENST00000375279.2_Missense_Mutation_p.A594V|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.A565V|CBFA2T2_ENST00000342704.5_Missense_Mutation_p.A585V	NM_005093.3	NP_005084.1	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	594						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						TCAACACCTGCTTCTGTGACA	0.627000													28	139					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1957858	1957858	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:1957858G>A	ENST00000382895.3	+	17	3255	c.2824G>A	c.(2824-2826)Ggg>Agg	p.G942R	WHSC1_ENST00000508803.1_Missense_Mutation_p.G942R|WHSC1_ENST00000382892.2_Missense_Mutation_p.G942R|WHSC1_ENST00000382888.3_Missense_Mutation_p.G290R|WHSC1_ENST00000382891.5_Missense_Mutation_p.G942R|WHSC1_ENST00000482415.2_3'UTR	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	942	PWWP 2.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GTACATGGAGGGGGACCGGGG	0.512000			T	IGH@	MM								95	230					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098833	11098833	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:11098833G>A	ENST00000470054.1	-	0	92									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		agagcgagacgagccacggtg	0.612000													6	54					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35792664	35792664	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35792664C>T	ENST00000342694.2	+	1	514	c.259C>T	c.(259-261)Ctc>Ttc	p.L87F		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	87					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	CGCTGTGGACCTCAAGCTGTA	0.662000													34	101					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113447007	113447007	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113447007G>A	ENST00000392583.2	+	10	2218	c.2011G>A	c.(2011-2013)Gat>Aat	p.D671N	OAS2_ENST00000342315.4_Missense_Mutation_p.D671N|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	671	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding	p.D671N(1)		NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CTGCTTCAAGGATGGGACTGG	0.512000													69	208					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118221228	118221228	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:118221228C>T	ENST00000402510.2	-	11	3964	c.3965G>A	c.(3964-3966)aGg>aAg	p.R1322K		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	1322										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TTTAGAATTCCTCCACTCTTT	0.488000													49	157					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48318381	48318381	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:48318381G>A	ENST00000435803.1	+	18	7614	c.7590G>A	c.(7588-7590)aaG>aaA	p.K2530K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2530					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AGCTGGTCAAGAAAGTTTCGG	0.413000													69	158					0	0	1	0	0
NAT6	24142	broad.mit.edu	37	3	50334222	50334222	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:50334222G>A	ENST00000443842.1	-	2	1480	c.673C>T	c.(673-675)Cca>Tca	p.P225S	NAT6_ENST00000443094.2_Missense_Mutation_p.P225S|NAT6_ENST00000417393.1_Missense_Mutation_p.P225S|HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000450982.1_Intron|NAT6_ENST00000354862.4_Missense_Mutation_p.P247S|HYAL3_ENST00000415204.1_Intron|HYAL3_ENST00000359051.3_Intron|HYAL3_ENST00000336307.1_Intron					N-acetyltransferase 6 (GCN5-related)											endometrium(3)|lung(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GTCAGGTTTGGGGCCTTCCTG	0.662000													20	42					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131848526	131848526	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:131848526C>T	ENST00000286355.5	-	12	4764	c.2672G>A	c.(2671-2673)gGa>gAa	p.G891E	ADCY8_ENST00000377928.3_Missense_Mutation_p.G760E	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	891					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CACTTACTCTCCACTGTGGTT	0.502000										HNSCC(32;0.087)			10	63					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10434093	10434093	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10434093G>A	ENST00000293677.6	-	4	1038	c.957C>T	c.(955-957)ccC>ccT	p.P319P		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	302	Interaction with PTBP1 (By similarity).					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			TACTGCGGCCGGGGGGCCCAG	0.716000													4	20					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12445349	12445349	+	Missense_Mutation	SNP	C	C	T	rs147684777		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12445349C>T	ENST00000358136.3	+	59	11531	c.11401C>T	c.(11401-11403)Cgt>Tgt	p.R3801C	VPS13D_ENST00000356315.4_Missense_Mutation_p.R3776C|VPS13D_ENST00000496628.1_3'UTR	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3800					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GAAAAGCAGCCGTTCATATGA	0.393000													5	66					0	0	1	0	0
FLYWCH1	84256	broad.mit.edu	37	16	2988351	2988351	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:2988351C>T	ENST00000399667.2	+	10	2454	c.2091C>T	c.(2089-2091)caC>caT	p.H697H	FLYWCH1_ENST00000416288.2_Silent_p.H647H|FLYWCH1_ENST00000570752.1_3'UTR|FLYWCH1_ENST00000253928.9_Silent_p.H648H			Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1	648						nucleus	DNA binding|metal ion binding			kidney(1)|lung(3)	4						CCCAGGGCCACCGCATCATGG	0.682000													8	17					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87041247	87041247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:87041247G>A	ENST00000265723.4	-	23	2997	c.2886C>T	c.(2884-2886)ctC>ctT	p.L962L	ABCB4_ENST00000358400.3_Intron|ABCB4_ENST00000545634.1_Silent_p.L962L|ABCB4_ENST00000359206.3_Silent_p.L962L|ABCB4_ENST00000453593.1_Intron	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	962	ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CATTCACAATGAGATATGCAC	0.323000													22	55					0	0	1	0	0
DUS2	54920	broad.mit.edu	37	16	68110572	68110572	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:68110572C>T	ENST00000565263.1	+	15	1614	c.1120C>T	c.(1120-1122)Cta>Tta	p.L374L	DUS2L_ENST00000432752.1_Silent_p.L339L|DUS2L_ENST00000358896.6_Silent_p.L374L	NM_017803.3	NP_060273.1	Q9NX74	DUS2L_HUMAN		374	DRBM.				tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|stomach(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		TAAGATGTGCCTACTAGAGTG	0.607000													21	88					0	0	1	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44364864	44364864	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44364864C>T	ENST00000262915.3	+	9	870	c.693C>T	c.(691-693)atC>atT	p.I231I	ST3GAL3_ENST00000461375.1_3'UTR|ST3GAL3_ENST00000351035.3_Silent_p.I200I|ST3GAL3_ENST00000361746.4_Silent_p.I231I|ST3GAL3_ENST00000347631.2_Silent_p.I177I|ST3GAL3_ENST00000372365.1_Silent_p.I162I|ST3GAL3_ENST00000372362.2_Intron|ST3GAL3_ENST00000372377.4_Intron|ST3GAL3_ENST00000330208.2_Intron|ST3GAL3_ENST00000372366.1_Silent_p.I161I|ST3GAL3_ENST00000372368.2_Silent_p.I216I|ST3GAL3_ENST00000332628.6_Silent_p.I131I|ST3GAL3_ENST00000335430.6_Silent_p.I146I|ST3GAL3_ENST00000545417.1_Intron|ST3GAL3_ENST00000372372.2_Silent_p.I200I|ST3GAL3_ENST00000372374.2_Silent_p.I131I|ST3GAL3_ENST00000372369.1_Silent_p.I162I|ST3GAL3_ENST00000353126.3_Silent_p.I162I|ST3GAL3_ENST00000372367.1_Silent_p.I161I|ST3GAL3_ENST00000361812.4_Intron|ST3GAL3_ENST00000361392.4_Silent_p.I162I|ST3GAL3_ENST00000361400.4_Silent_p.I146I|ST3GAL3_ENST00000533933.1_Silent_p.I162I|ST3GAL3_ENST00000531993.1_Silent_p.I146I|ST3GAL3_ENST00000531816.1_Intron|ST3GAL3_ENST00000531451.1_Intron|ST3GAL3_ENST00000528371.1_Silent_p.I146I|ST3GAL3_ENST00000372375.2_Silent_p.I216I	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	162					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				GCTGCATCATCGTGGGCAATG	0.592000													24	75					0	0	1	0	0
POLL	27343	broad.mit.edu	37	10	103345861	103345861	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103345861G>A	ENST00000370162.3	-	3	662	c.168C>T	c.(166-168)gcC>gcT	p.A56A	POLL_ENST00000370172.1_5'UTR|POLL_ENST00000370158.3_Intron|POLL_ENST00000339310.3_Intron|POLL_ENST00000299206.4_Silent_p.A56A|DPCD_ENST00000470165.1_Intron|POLL_ENST00000456836.2_Intron|POLL_ENST00000436284.2_5'UTR|DPCD_ENST00000416979.2_Intron|POLL_ENST00000370169.1_Silent_p.A56A	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	56	BRCT.				DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GTTCTGCCCGGGCTCGTCCAA	0.537000								DNA polymerases (catalytic subunits)					18	45					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160901448	160901448	+	Silent	SNP	G	G	A	rs147284017	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:160901448G>A	ENST00000283243.7	-	2	536	c.330C>T	c.(328-330)ctC>ctT	p.L110L	PLA2R1_ENST00000392771.1_Silent_p.L110L	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	110	Ricin B-type lectin.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GTAAGGAAACGAGGGTGGAGT	0.542000													28	77					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739639	15739639	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:15739639C>T	ENST00000441682.2	+	0	1444							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						TTATTCCTTTCTCGGCGGGGC	0.597000													28	85					0	0	1	0	0
SYS1	90196	broad.mit.edu	37	20	43995655	43995655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:43995655C>T	ENST00000243918.5	+	4	662	c.371C>T	c.(370-372)gCc>gTc	p.A124V	SYS1_ENST00000414310.1_Missense_Mutation_p.A103V|SYS1_ENST00000426004.1_Intron|SYS1-DBNDD2_ENST00000475242.1_Intron|SYS1_ENST00000372727.1_Missense_Mutation_p.A124V|SYS1_ENST00000479779.1_3'UTR|SYS1-DBNDD2_ENST00000452133.1_Intron	NM_033542.3	NP_291020.1	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)	124					protein transport	Golgi membrane|integral to membrane				cervix(1)|endometrium(2)|large_intestine(2)|prostate(1)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				CTGGTCCAAGCCGTGTGCATT	0.562000													20	103					0	0	1	0	0
C17orf74	201243	broad.mit.edu	37	17	7329881	7329881	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:7329881C>T	ENST00000574034.1	+	3	281	c.233C>T	c.(232-234)cCt>cTt	p.P78L	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000333870.3_Silent_p.L191L			Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	0						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				GGAGGACAACCTGCCCTTCCC	0.602000													53	59					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11532847	11532847	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:11532847G>A	ENST00000262442.3	+	7	1532	c.1464G>A	c.(1462-1464)gaG>gaA	p.E488E	DNAH9_ENST00000579406.1_3'UTR|DNAH9_ENST00000454412.2_Silent_p.E488E	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	488	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AATTTCAAGAGATGTACAGGC	0.557000													33	47					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28607230	28607230	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:28607230C>T	ENST00000253063.3	+	10	1681	c.1360C>T	c.(1360-1362)Cac>Tac	p.H454Y		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	454					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCCAGGTCCACGTGAACTT	0.612000													13	66					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1104238	1104238	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:1104238C>T	ENST00000441003.2	+	49	8456	c.8429C>T	c.(8428-8430)tCc>tTc	p.S2810F		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	5172						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GCCCGGCGCTCCCCTAGGCAT	0.706000													4	21					0	0	1	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75557688	75557688	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75557688G>A	ENST00000300576.5	+	9	682	c.682G>A	c.(682-684)Gag>Aag	p.E228K		NM_001164404.1	NP_001157876.1	A6NDK9	GOG6C_HUMAN	golgin A6 family, member C	228										ovary(1)	1						AGTCCAGCTAGAGCGGGACGA	0.552000													62	458					0	0	1	0	0
CRTAC1	55118	broad.mit.edu	37	10	99625472	99625472	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:99625472C>T	ENST00000370597.3	-	15	2175		c.e15-1		GOLGA7B_ENST00000370602.1_3'UTR|CRTAC1_ENST00000298819.4_Splice_Site	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1							proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CCGAGAGTCCCTGTAGGGAGG	0.692000													6	11					0	0	1	0	0
ZNF33A	7581	broad.mit.edu	37	10	38345344	38345344	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:38345344C>T	ENST00000374618.3	+	5	2470	c.2292C>T	c.(2290-2292)ctC>ctT	p.L764L	ZNF33A_ENST00000432900.2_Silent_p.L770L|ZNF33A_ENST00000469037.2_Intron|ZNF33A_ENST00000307441.9_Silent_p.L763L|ZNF33A_ENST00000458705.2_Silent_p.L763L	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	763						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						AGTCAAATCTCATTGTACATC	0.383000													30	90					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756965	71756965	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:71756965G>A	ENST00000318442.5	-	2	849	c.359C>T	c.(358-360)cCg>cTg	p.P120L		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CTTGGGGCGCGGGGGCTGCGG	0.582000													74	188					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30350066	30350066	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:30350066G>A	ENST00000359358.4	-	2	927	c.489C>T	c.(487-489)atC>atT	p.I163I	KLHL14_ENST00000358095.4_Silent_p.I163I|AC012123.1_ENST00000426194.1_Intron	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	163						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GGATGTGCAGGATCTTGCTGA	0.622000													19	89					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509476	71509476	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71509476G>A	ENST00000396073.3	+	9	2614	c.2333G>A	c.(2332-2334)aGa>aAa	p.R778K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	778					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			CAGAGAGAAAGAAGGCCGTAT	0.473000													25	72					0	0	1	0	0
RLTPR	146206	broad.mit.edu	37	16	67680152	67680152	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:67680152G>A	ENST00000334583.6	+	5	641	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	RLTPR_ENST00000545661.1_Missense_Mutation_p.E105K	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	105										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGCCGCCCTGGAACAGCTGGC	0.637000													15	22					0	0	1	0	0
C2orf50	130813	broad.mit.edu	37	2	11284107	11284107	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:11284107C>T	ENST00000381585.3	+	3	641	c.359C>T	c.(358-360)cCc>cTc	p.P120L	C2orf50_ENST00000405022.3_Missense_Mutation_p.P120L			Q96LR7	CB050_HUMAN	chromosome 2 open reading frame 50	120										breast(1)|large_intestine(1)|upper_aerodigestive_tract(1)	3	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0997)|OV - Ovarian serous cystadenocarcinoma(76;0.134)		GACACAGTTCCCAGTTCCACG	0.582000													19	71					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54275341	54275341	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:54275341G>A	ENST00000354646.2	-	17	3878	c.3440C>T	c.(3439-3441)tCc>tTc	p.S1147F	WNK3_ENST00000375169.3_Missense_Mutation_p.S1147F|WNK3_ENST00000375159.2_Missense_Mutation_p.S1147F	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1147					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						TTCAGCAGAGGAAGAAAATGG	0.438000													40	53					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	54060279	54060279	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:54060279G>A	ENST00000312233.2	-	3	863	c.297C>T	c.(295-297)acC>acT	p.T99T		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	99					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						CATTTACACAGGTGACCAGAG	0.677000													23	41					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42880695	42880695	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:42880695C>T	ENST00000334370.4	+	41	8740	c.8105C>T	c.(8104-8106)aCt>aTt	p.T2702I	MEGF8_ENST00000251268.6_Missense_Mutation_p.T2769I|MEGF8_ENST00000378073.4_Missense_Mutation_p.T363I	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2769						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GGGCCCATCACTCTCGAGCCC	0.721000													3	5					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40357655	40357655	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40357655C>T	ENST00000221347.6	-	34	15665	c.15658G>A	c.(15658-15660)Gag>Aag	p.E5220K		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5220						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCTTGACCTCACATACACGG	0.637000													23	53					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871098	51871098	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:51871098C>T	ENST00000371497.5	+	2	1988	c.1101C>T	c.(1099-1101)agC>agT	p.S367S	TSHZ2_ENST00000329613.6_Silent_p.S364S|TSHZ2_ENST00000603338.2_Silent_p.S364S	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	367					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			ATGGAGCCAGCTACACCTGGC	0.502000													30	73					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231035380	231035380	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:231035380C>T	ENST00000258381.6	-	18	2062	c.1985G>A	c.(1984-1986)cGa>cAa	p.R662Q	SP110_ENST00000358662.4_Missense_Mutation_p.R638Q	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	638	Bromo.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		GCGCATGTCTCGCACAAACCA	0.443000													43	62					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187953	140187953	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140187953C>T	ENST00000530339.1	+	1	1181	c.1181C>T	c.(1180-1182)cCc>cTc	p.P394L	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.P394L|PCDHA4_ENST00000512229.2_Missense_Mutation_p.P394L|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCACGTCCCCTTCAAGCTG	0.592000													19	173					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155156834	155156834	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:155156834G>A	ENST00000357232.3	-	25	7604	c.7605C>T	c.(7603-7605)ttC>ttT	p.F2535F		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2535					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.F2535F(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGCTGCTGGCGAACACTGCCA	0.388000													29	69					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5072529	5072529	+	Missense_Mutation	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:5072529T>C	ENST00000381652.3	+	13	2173	c.1679T>C	c.(1678-1680)tTt>tCt	p.F560S	JAK2_ENST00000544510.1_Missense_Mutation_p.F411S|JAK2_ENST00000539801.1_Missense_Mutation_p.F560S	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	560	Protein kinase 1.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		ACAAAGATTTTTAAAGGCGTA	0.373000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				25	53					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47515777	47515777	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47515777C>T	ENST00000371901.3	+	12	1711	c.1461C>T	c.(1459-1461)ttC>ttT	p.F487F	CYP4X1_ENST00000538609.1_Silent_p.F486F	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	487						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						CTCTTACTTTCCCCAACCATT	0.448000													43	127					0	0	1	0	0
PITX3	5309	broad.mit.edu	37	10	103990562	103990562	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:103990562C>T	ENST00000370002.3	-	4	771	c.618G>A	c.(616-618)ccG>ccA	p.P206P	PITX3_ENST00000539804.1_Silent_p.P206P	NM_005029.3	NP_005020.1	O75364	PITX3_HUMAN	paired-like homeodomain 3	206					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(2)	5		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCACGGTGCCCGGGGCAGCCG	0.761000													4	3					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81172151	81172151	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:81172151C>T	ENST00000394685.3	+	5	755	c.336C>T	c.(334-336)gcC>gcT	p.A112A	KIAA1199_ENST00000356249.5_Silent_p.A112A|KIAA1199_ENST00000220244.3_Silent_p.A112A			Q8WUJ3	K1199_HUMAN	KIAA1199	112	G8.									breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						CTGGGAGTGCCCTCTGCCCTT	0.517000													10	92					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48461033	48461033	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:48461033G>A	ENST00000358536.4	-	11	2931	c.2662C>T	c.(2662-2664)Ccg>Tcg	p.P888S	PLXNB1_ENST00000456774.1_Missense_Mutation_p.P705S|PLXNB1_ENST00000296440.6_Missense_Mutation_p.P888S|PLXNB1_ENST00000358459.4_Missense_Mutation_p.P705S|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	888					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGGCTGGACGGGAGGATGAGG	0.672000													11	31					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49685891	49685891	+	Silent	SNP	C	C	T	rs145772095		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:49685891C>T	ENST00000252826.5	+	11	1446	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F	TRPM4_ENST00000427978.2_Silent_p.F440F|TRPM4_ENST00000601347.1_3'UTR|TRPM4_ENST00000355712.5_Silent_p.F86F	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	440					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGCCTGAGTTCGTGCGCTTGC	0.607000													7	71					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24256521	24256521	+	Silent	SNP	G	G	A	rs141164035		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:24256521G>A	ENST00000538205.1	+	10	1207	c.660G>A	c.(658-660)ggG>ggA	p.G220G	ADAMDEC1_ENST00000522298.1_Silent_p.G220G|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000256412.4_Silent_p.G299G	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	299	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding	p.G299G(1)		NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CTAACCTGGGGAAAAAGATCC	0.512000													17	36					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29293604	29293604	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:29293604G>A	ENST00000331664.5	-	1	3523	c.3524C>T	c.(3523-3525)tCg>tTg	p.S1175L		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1175					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TCTCCGCTGCGAGTCTGCTCT	0.657000													17	58					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5021916	5021916	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:5021916G>A	ENST00000382545.3	+	2	2479	c.1372G>A	c.(1372-1374)Gaa>Aaa	p.E458K	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	458					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATGGAGATCGAAGAGGATAT	0.463000													68	139					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49848490	49848490	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:49848490C>T	ENST00000333486.3	-	10	1315	c.1157G>A	c.(1156-1158)tGg>tAg	p.W386*		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	386	2 approximate repeats.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AAAGTAAAGCCACTGGTCCAG	0.602000													15	41					0	0	1	0	0
NDUFS3	4722	broad.mit.edu	37	11	47605951	47605951	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47605951C>T	ENST00000263774.4	+	7	795	c.713C>T	c.(712-714)cCc>cTc	p.P238L	NDUFS3_ENST00000533507.1_3'UTR	NM_004551.2	NP_004542.1	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)	238					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)	9					NADH(DB00157)	CTGAACAGCCCCTGGGAGGCT	0.557000													47	113					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41019027	41019027	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41019027C>T	ENST00000399564.4	-	25	2985	c.2535G>A	c.(2533-2535)ctG>ctA	p.L845L	MROH2B_ENST00000506092.2_Silent_p.L400L	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		CTTCACTTTTCAGATTTTCCA	0.473000													13	30					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27692272	27692272	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:27692272C>T	ENST00000438700.3	-	3	1343	c.1226G>A	c.(1225-1227)cGa>cAa	p.R409Q		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	409	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CATTTTGTTTCGTATGCAGTC	0.443000													35	54					0	0	1	0	0
SLC34A1	6569	broad.mit.edu	37	5	176820706	176820706	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:176820706C>T	ENST00000324417.5	+	9	1039	c.948C>T	c.(946-948)tcC>tcT	p.S316S	SLC34A1_ENST00000513614.1_3'UTR	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	316					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCCCACCTCCATGTCCAGAG	0.552000													22	86					0	0	1	0	0
POPDC3	64208	broad.mit.edu	37	6	105609583	105609583	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:105609583C>T	ENST00000254765.3	-	2	480	c.202G>A	c.(202-204)Gct>Act	p.A68T	BVES-AS1_ENST00000580854.1_RNA|POPDC3_ENST00000474760.1_Intron|BVES-AS1_ENST00000580511.1_RNA|BVES-AS1_ENST00000369122.3_RNA	NM_022361.4	NP_071756.2	Q9HBV1	POPD3_HUMAN	popeye domain containing 3	68						integral to membrane				NS(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(3)|urinary_tract(1)	26		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				TCTACCCAAGCCCAGACAGCA	0.423000													45	55					0	0	1	0	0
ENO1	2023	broad.mit.edu	37	1	8924025	8924025	+	Missense_Mutation	SNP	G	G	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8924025G>T	ENST00000234590.4	-	9	1111	c.992C>A	c.(991-993)gCc>gAc	p.A331D		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	331					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CTCGTTCACGGCCTTGGCGAT	0.567000													81	212					2.61628e-32	2.63462e-32	1	1	0
IGHV3-21	28444	broad.mit.edu	37	14	106692098	106692098	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106692098G>A	ENST00000390607.2	-	0	105																											TAGCAACAAGGAAAACCCAGC	0.483000													60	167					0	0	1	0	0
CLCN3	1182	broad.mit.edu	37	4	170618355	170618355	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:170618355C>T	ENST00000513761.1	+	9	1592	c.1033C>T	c.(1033-1035)Cct>Tct	p.P345S	CLCN3_ENST00000347613.4_Missense_Mutation_p.P345S|CLCN3_ENST00000504131.2_Missense_Mutation_p.P328S|CLCN3_ENST00000360642.3_Missense_Mutation_p.P318S	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	345					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		CTATTATTTTCCTCTCAAAAC	0.294000													35	64					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54902260	54902260	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54902260C>T	ENST00000293373.6	+	5	530	c.451C>T	c.(451-453)Cgg>Tgg	p.R151W	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R101W	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	151					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GATTGAAGATCGGCGGATACT	0.423000													99	155					0	0	1	0	0
PIH1D3	139212	broad.mit.edu	37	X	106482183	106482183	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:106482183C>T	ENST00000535523.1	+	7	798	c.461C>T	c.(460-462)tCt>tTt	p.S154F	PIH1D3_ENST00000372453.3_Missense_Mutation_p.S154F|PIH1D3_ENST00000336387.4_Missense_Mutation_p.S154F	NM_001169154.1	NP_001162625.1			PIH1 domain containing 3																		ACAAACCCTTCTGATATTCAA	0.299000													27	12					0	0	1	0	0
FAM78B	149297	broad.mit.edu	37	1	166135291	166135291	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:166135291G>A	ENST00000338353.3	-	2	784	c.195C>T	c.(193-195)acC>acT	p.T65T	FAM78B_ENST00000354422.3_Silent_p.T65T			Q5VT40	FA78B_HUMAN	family with sequence similarity 78, member B	65										central_nervous_system(1)|endometrium(5)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					CCACCACCCAGGTCTCGTGGC	0.652000													13	24					0	0	1	0	0
CD3E	916	broad.mit.edu	37	11	118183534	118183534	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:118183534G>A	ENST00000361763.4	+	6	596	c.305G>A	c.(304-306)gGa>gAa	p.G102E	CD3E_ENST00000528600.1_Missense_Mutation_p.G96E	NM_000733.3	NP_000724.1	P07766	CD3E_HUMAN	CD3e molecule, epsilon (CD3-TCR complex)	102	Ig-like.				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|ovary(2)|stomach(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	TACCCCAGAGGAAGCAAACCA	0.458000													14	109					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43763125	43763125	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:43763125C>T	ENST00000389420.3	-	37	5505	c.5506G>A	c.(5506-5508)Gga>Aga	p.G1836R		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1836	GON.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TAGCAATCTCCAGCTGTGGCA	0.318000													4	14					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61424021	61424021	+	Missense_Mutation	SNP	C	C	T	rs145829924		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61424021C>T	ENST00000395348.3	-	4	1036	c.400G>A	c.(400-402)Gat>Aat	p.D134N	SLC16A9_ENST00000395347.1_Missense_Mutation_p.D134N	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	134					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						CCTCGGCGATCGTCAAAATAC	0.393000													27	53					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38949552	38949552	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38949552G>A	ENST00000302328.3	-	10	1559	c.1361C>T	c.(1360-1362)aCc>aTc	p.T454I	SCN11A_ENST00000456224.3_Missense_Mutation_p.T454I|SCN11A_ENST00000444237.2_Missense_Mutation_p.T454I|SCN11A_ENST00000450244.1_Missense_Mutation_p.T454I	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	454					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTTTTTGGGGTAAAATATGA	0.388000													36	94					0	0	1	0	0
DEFB114	245928	broad.mit.edu	37	6	49928133	49928133	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:49928133G>A	ENST00000322066.3	-	2	81	c.82C>T	c.(82-84)Cgt>Tgt	p.R28C		NM_001037499.1	NP_001032588.1	Q30KQ6	DB114_HUMAN	defensin, beta 114	28					defense response to bacterium	extracellular region		p.R28C(1)		kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	Lung NSC(77;0.042)					TTGGTGCAACGATCAGCATTC	0.353000													13	51					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107706335	107706335	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:107706335G>A	ENST00000388781.3	-	21	2791	c.2708C>T	c.(2707-2709)tCt>tTt	p.S903F	LAMB4_ENST00000205386.4_Missense_Mutation_p.S903F|LAMB4_ENST00000388780.3_Missense_Mutation_p.S903F	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	903	Laminin EGF-like 8.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CTGTCCTGAAGAAGGATTTCC	0.433000													8	118					0	0	1	0	0
ZNF605	100289635	broad.mit.edu	37	12	133502373	133502373	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:133502373G>A	ENST00000360187.4	-	5	1860	c.1512C>T	c.(1510-1512)ccC>ccT	p.P504P	ZNF605_ENST00000392321.3_Silent_p.P535P	NM_183238.3	NP_899061.1	Q86T29	ZN605_HUMAN	zinc finger protein 605	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(16)|large_intestine(5)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00227)|all_epithelial(31;0.142)		OV - Ovarian serous cystadenocarcinoma(86;9.24e-09)|Epithelial(86;2.11e-07)|all cancers(50;5.27e-06)		TACATTCAAAGGGCTTTTCTC	0.428000													20	25					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	70987106	70987106	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70987106G>A	ENST00000354624.5	+	2	340	c.207G>A	c.(205-207)agG>agA	p.R69R	RP11-227H15.4_ENST00000450995.1_RNA|HKDC1_ENST00000395086.2_Silent_p.R69R	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	69					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CCTTCGTCAGGGCCATTCCCG	0.582000													12	45					0	0	1	0	0
TPM2	7169	broad.mit.edu	37	9	35685445	35685445	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:35685445G>A	ENST00000378292.3	-	4	1680	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	TPM2_ENST00000378300.5_Missense_Mutation_p.R160C|TPM2_ENST00000329305.2_Missense_Mutation_p.R160C|TPM2_ENST00000360958.2_Missense_Mutation_p.R160C	NM_213674.1	NP_998839.1	P07951	TPM2_HUMAN	tropomyosin 2 (beta)	160					muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle	p.R160S(2)		NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCATATTTGCGGTCTGAATCC	0.542000													28	120					0	0	1	0	0
POLR3D	661	broad.mit.edu	37	8	22106037	22106037	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:22106037C>T	ENST00000397802.4	+	5	745	c.530C>T	c.(529-531)cCt>cTt	p.P177L	POLR3D_ENST00000306433.4_Missense_Mutation_p.P177L			P05423	RPC4_HUMAN	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	177					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	13				Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CGAAATATGCCTGTGCAGCTG	0.537000													40	88					0	0	1	0	0
UBE2U	148581	broad.mit.edu	37	1	64671357	64671357	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:64671357G>A	ENST00000371077.4	+	2	526	c.102G>A	c.(100-102)atG>atA	p.M34I	UBE2U_ENST00000371076.3_Missense_Mutation_p.M34I			Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)	34							ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(3)|lung(2)|skin(1)	6						AAGATATGATGGAATGGGAAG	0.274000													21	92					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16170511	16170511	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:16170511C>T	ENST00000380289.2	+	3	1296	c.898C>T	c.(898-900)Cac>Tac	p.H300Y		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	300					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					CTCCATGCTCCACTTTGTCAC	0.562000													77	88					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2717815	2717815	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:2717815C>T	ENST00000399655.1	+	27	3760	c.3495C>T	c.(3493-3495)gtC>gtT	p.V1165V	CACNA1C_ENST00000399637.1_Silent_p.V1165V|CACNA1C_ENST00000480911.1_Silent_p.V1165V|CACNA1C_ENST00000335762.5_Silent_p.V1190V|CACNA1C_ENST00000399603.1_Silent_p.V1165V|CACNA1C_ENST00000399649.1_Silent_p.V1165V|CACNA1C_ENST00000399595.1_Silent_p.V1165V|CACNA1C_ENST00000399606.1_Silent_p.V1185V|CACNA1C_ENST00000399601.1_Silent_p.V1165V|CACNA1C_ENST00000399617.1_Silent_p.V1165V|CACNA1C_ENST00000344100.3_Silent_p.V1165V|CACNA1C_ENST00000399621.1_Silent_p.V1165V|CACNA1C_ENST00000399629.1_Silent_p.V1165V|CACNA1C_ENST00000327702.7_Silent_p.V1165V|CACNA1C_ENST00000406454.3_Silent_p.V1165V|CACNA1C_ENST00000402845.3_Silent_p.V1165V|CACNA1C_ENST00000399597.1_Silent_p.V1165V|CACNA1C_ENST00000347598.4_Silent_p.V1185V|CACNA1C_ENST00000399641.1_Silent_p.V1165V|CACNA1C_ENST00000399638.1_Silent_p.V1165V|CACNA1C_ENST00000399644.1_Silent_p.V1165V|CACNA1C_ENST00000399591.1_Silent_p.V1165V|CACNA1C_ENST00000399634.1_Silent_p.V1165V	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1185	Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	tgggcttcgtcatcgtcaccT	0.532000													12	37					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38917285	38917285	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38917285G>A	ENST00000359357.3	+	79	11790	c.11536G>A	c.(11536-11538)Gaa>Aaa	p.E3846K	RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Missense_Mutation_p.E4063K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E3810K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TCCAGAGGAGGAAATTATCCC	0.388000													32	130					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73206137	73206137	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:73206137G>A	ENST00000224721.6	+	2	135	c.130G>A	c.(130-132)Gag>Aag	p.E44K	CDH23_ENST00000398809.4_Missense_Mutation_p.E44K|CDH23_ENST00000398842.3_Missense_Mutation_p.E44K|CDH23_ENST00000299366.7_Missense_Mutation_p.E89K|CDH23_ENST00000461841.3_Missense_Mutation_p.E89K	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	44	Cadherin 1.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GCTGATCAGCGAGGACACGCC	0.587000													23	46					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21235111	21235111	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21235111G>A	ENST00000233242.1	-	26	4756	c.4629C>T	c.(4627-4629)tcC>tcT	p.S1543S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1543					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGAGGTGAGGGAGAGGGTTC	0.468000													24	78					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71538258	71538258	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71538258G>A	ENST00000265382.3	+	12	1462	c.1157G>A	c.(1156-1158)aGa>aAa	p.R386K	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.R386K	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	386	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		TATGCAGACAGATTTCTTAAG	0.328000													17	71					0	0	1	0	0
RASSF8	11228	broad.mit.edu	37	12	26217491	26217491	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:26217491C>T	ENST00000405154.2	+	3	363	c.164C>T	c.(163-165)cCt>cTt	p.P55L	RASSF8_ENST00000542865.1_Missense_Mutation_p.P55L|RASSF8_ENST00000282884.9_Missense_Mutation_p.P55L|RASSF8_ENST00000381352.3_Missense_Mutation_p.P55L|RASSF8_ENST00000541490.1_Missense_Mutation_p.P55L	NM_001164748.1	NP_001158220.1	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	55	Ras-associating.				signal transduction					cervix(2)|endometrium(1)|large_intestine(6)|lung(15)|urinary_tract(1)	25	Colorectal(261;0.0847)					CACTTAGCACCTCATGAAAAT	0.428000													27	119					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921586	247921586	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:247921586C>T	ENST00000408896.2	-	1	396	c.123G>A	c.(121-123)ggG>ggA	p.G41G		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGAGCATGTTCCCCAAGGTGG	0.483000													10	31					0	0	1	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156725803	156725803	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:156725803C>T	ENST00000264424.8	+	12	1695	c.1613C>T	c.(1612-1614)cCt>cTt	p.P538L	GUCY1B3_ENST00000505154.1_Missense_Mutation_p.P470L|GUCY1B3_ENST00000513437.1_Missense_Mutation_p.P470L|GUCY1B3_ENST00000507146.1_Missense_Mutation_p.P513L|GUCY1B3_ENST00000503520.1_Missense_Mutation_p.P505L|GUCY1B3_ENST00000502959.1_Missense_Mutation_p.P560L|GUCY1B3_ENST00000505764.1_Missense_Mutation_p.P518L	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	538	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		CAGCGGATGCCTCGATACTGT	0.398000													13	100					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44975176	44975176	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:44975176C>T	ENST00000340446.4	-	1	1306	c.1015G>A	c.(1015-1017)Gaa>Aaa	p.E339K		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	339	Pro-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		GGAGACTCTTCAGCTGATGGA	0.517000													33	117					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183245205	183245205	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183245205C>T	ENST00000511685.1	+	2	155	c.32C>T	c.(31-33)tCc>tTc	p.S11F	TENM3_ENST00000406950.2_Missense_Mutation_p.S11F					teneurin transmembrane protein 3																		CCTTACTGCTCCCTGACCAAG	0.522000													13	28					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57809130	57809130	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:57809130C>T	ENST00000281282.5	+	9	2634	c.2556C>T	c.(2554-2556)atC>atT	p.I852I		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	852						myosin complex|tight junction	motor activity	p.I852I(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AAAGGCAGATCGAGGACCTGA	0.577000													8	32					0	0	1	0	0
KANSL1L	151050	broad.mit.edu	37	2	211018911	211018911	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:211018911G>A	ENST00000281772.9	-	2	659	c.396C>T	c.(394-396)ttC>ttT	p.F132F	KANSL1L_ENST00000429908.2_5'UTR|KANSL1L_ENST00000418791.1_Silent_p.F132F|KANSL1L_ENST00000452086.1_Silent_p.F132F|KANSL1L_ENST00000457374.1_Silent_p.F132F	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	132																	CCTTTTTGATGAACTCTTCAG	0.368000													35	85					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46868965	46868965	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:46868965C>T	ENST00000393382.3	-	9	1140	c.998_splice	c.e9-1	p.R333_splice	TTLL6_ENST00000433608.2_Splice_Site_p.R26_splice	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	285	TTL.					cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						TGGAGAGCTTCCTGGAAGGGA	0.562000											OREG0024526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	19					0	0	1	0	0
GOLGA7	51125	broad.mit.edu	37	8	41355058	41355058	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:41355058C>T	ENST00000357743.4	+	2	343	c.142C>T	c.(142-144)Cga>Tga	p.R48*	GOLGA7_ENST00000405786.2_Nonsense_Mutation_p.R48*|GOLGA7_ENST00000518270.1_Nonsense_Mutation_p.R48*|GOLGA7_ENST00000520817.1_Nonsense_Mutation_p.R48*	NM_001002296.1	NP_001002296.1	Q7Z5G4	GOGA7_HUMAN	golgin A7	48						Golgi membrane				breast(1)|large_intestine(1)	2	Ovarian(28;0.014)|Colorectal(14;0.0234)|Lung SC(25;0.211)	all_lung(54;0.000771)|Lung NSC(58;0.0031)|Hepatocellular(245;0.014)|Esophageal squamous(32;0.0559)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00596)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AGAAACAGTTCGAACTCTAAA	0.348000													76	137					0	0	1	0	0
MPPE1	65258	broad.mit.edu	37	18	11886545	11886545	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:11886545G>A	ENST00000588072.1	-	9	2041	c.820C>T	c.(820-822)Cca>Tca	p.P274S	MPPE1_ENST00000399978.2_Missense_Mutation_p.P275S|MPPE1_ENST00000344987.7_Missense_Mutation_p.P252S|MPPE1_ENST00000317235.7_Intron|MPPE1_ENST00000309976.9_Intron	NM_023075.5	NP_075563.3	Q53F39	MPPE1_HUMAN	metallophosphoesterase 1	274					ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	5						TCCTTAAATGGGATGTCCCTT	0.507000													26	51					0	0	1	0	0
CTD-2090I13.1	0	broad.mit.edu	37	1	227618464	227618464	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:227618464C>T	ENST00000445817.1	+	0	1699																											AGTACAAGATCCCGGACTGGT	0.488000													7	18					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202052442	202052442	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:202052442G>A	ENST00000286186.6	+	3	796	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K	CASP10_ENST00000313728.7_Missense_Mutation_p.E121K|CASP10_ENST00000272879.5_Missense_Mutation_p.E121K|CASP10_ENST00000346817.5_Missense_Mutation_p.E121K|CASP10_ENST00000448480.1_Missense_Mutation_p.E121K|CASP10_ENST00000374650.3_Missense_Mutation_p.E121K|CASP10_ENST00000360132.3_Missense_Mutation_p.E121K|CASP10_ENST00000492363.1_3'UTR	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	121	DED 2.				apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						CCTGCTCTACGAACTGTCAGA	0.403000													34	95					0	0	1	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269704	150269704	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:150269704C>T	ENST00000255945.2	+	3	721	c.546C>T	c.(544-546)ttC>ttT	p.F182F	GIMAP4_ENST00000461940.1_Silent_p.F196F|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	182							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGACATTTTCGGTGACCGCT	0.512000													44	92					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120845	94120845	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:94120845C>T	ENST00000369303.4	-	3	390	c.206G>A	c.(205-207)cGa>cAa	p.R69Q	EPHA7_ENST00000369297.1_Missense_Mutation_p.R69Q	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	69						integral to plasma membrane	ATP binding|ephrin receptor activity	p.R69Q(1)		NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CTGGTATGTTCGTATCGGGGT	0.393000													35	61					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62844957	62844957	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:62844957G>A	ENST00000536311.1	+	10	1952	c.1588G>A	c.(1588-1590)Gga>Aga	p.G530R	MYT1_ENST00000328439.1_Missense_Mutation_p.G530R|MYT1_ENST00000360149.4_Missense_Mutation_p.G232R			Q01538	MYT1_HUMAN	myelin transcription factor 1	530					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCCGCAGACAGGAGATCCTTC	0.542000													27	45					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81647354	81647354	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:81647354C>T	ENST00000548058.1	+	15	2810	c.1900C>T	c.(1900-1902)Cga>Tga	p.R634*	ACSS3_ENST00000548324.1_Nonsense_Mutation_p.R316*|ACSS3_ENST00000261206.3_Nonsense_Mutation_p.R633*			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	634						mitochondrion	acetate-CoA ligase activity|ATP binding	p.R634*(2)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GGCTGCTTTTCGAAATGCAGT	0.428000													21	93					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251424	25251424	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:25251424G>A	ENST00000328086.7	-	7	3420	c.2617C>T	c.(2617-2619)Cat>Tat	p.H873Y		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	873					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		GCGCTGAAATGAGAACTGTTG	0.453000													25	49					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101491710	101491710	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:101491710G>A	ENST00000392979.3	+	20	2249	c.1888G>A	c.(1888-1890)Gaa>Aaa	p.E630K	ANO4_ENST00000550015.1_Missense_Mutation_p.E185K|ANO4_ENST00000392977.3_Missense_Mutation_p.E665K|ANO4_ENST00000299222.9_Missense_Mutation_p.E185K	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	665						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						taatttcatggaacttggcta	0.413000										HNSCC(74;0.22)			46	104					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142435638	142435638	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:142435638C>T	ENST00000378004.3	+	16	1774	c.1419C>T	c.(1417-1419)ttC>ttT	p.F473F	ARHGAP26_ENST00000274498.4_Silent_p.F473F	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	473	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAGAAGTTTCATCAAAGCAG	0.343000													12	135					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201286864	201286864	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:201286864C>T	ENST00000263946.3	+	5	1262	c.1011C>T	c.(1009-1011)ctC>ctT	p.L337L	PKP1_ENST00000475988.1_3'UTR|PKP1_ENST00000367324.3_Silent_p.L337L|PKP1_ENST00000352845.3_Silent_p.L337L	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	337					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						CAGTCAGCCTCCTGAGGAGAA	0.647000													11	31					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75111616	75111616	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:75111616G>A	ENST00000379709.3	+	6	723	c.721G>A	c.(721-723)Gag>Aag	p.E241K	LMAN1L_ENST00000309664.5_Intron			Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	241	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCTGGCAGGTGAGGATCCCAC	0.572000													44	167					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124348598	124348598	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:124348598G>A	ENST00000368909.3	+	17	2028	c.1922G>A	c.(1921-1923)aGg>aAg	p.R641K	DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368955.3_Missense_Mutation_p.R631K|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000344338.3_Missense_Mutation_p.R631K|DMBT1_ENST00000338354.3_Missense_Mutation_p.R641K	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	641	SRCR 5.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTGGTCTGCAGGCAGCTGGGC	0.612000													36	389					0	0	1	0	0
ASAP3	55616	broad.mit.edu	37	1	23763453	23763453	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:23763453G>A	ENST00000336689.3	-	15	1471	c.1427C>T	c.(1426-1428)tCg>tTg	p.S476L	ASAP3_ENST00000437606.2_Missense_Mutation_p.S467L|ASAP3_ENST00000484906.1_5'UTR	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	476	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						CTGCATGCGCGAAAAGCGCAC	0.662000													3	27					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519613	113519613	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:113519613C>T	ENST00000284601.3	-	4	1602	c.1534G>A	c.(1534-1536)Ggc>Agc	p.G512S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	512					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTACCATTGCCATAATAATCT	0.323000													10	34					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47610048	47610048	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47610048G>A	ENST00000371890.3	+	6	691	c.655G>A	c.(655-657)Gaa>Aaa	p.E219K	CYP4A22_ENST00000371891.3_Silent_p.R270R|CYP4A22_ENST00000485117.1_3'UTR|CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000294337.3_Silent_p.R270R			Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	0						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCCAACTGAGGAAGGCTCAAC	0.542000													23	118					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390723	197390723	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:197390723G>A	ENST00000367400.3	+	6	1900	c.1765G>A	c.(1765-1767)Gag>Aag	p.E589K	CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000535699.1_Missense_Mutation_p.E520K|CRB1_ENST00000543483.1_Intron|CRB1_ENST00000538660.1_Missense_Mutation_p.E589K|CRB1_ENST00000544212.1_Missense_Mutation_p.E70K|CRB1_ENST00000367399.2_Missense_Mutation_p.E477K	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	589	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTCCTGTAAGGAGAAATGCAT	0.458000													36	117					0	0	1	0	0
BTBD17	388419	broad.mit.edu	37	17	72356361	72356361	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:72356361C>T	ENST00000375366.3	-	2	235	c.109G>A	c.(109-111)Gag>Aag	p.E37K		NM_001080466.1	NP_001073935.1	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17	37						extracellular region				endometrium(1)|kidney(1)|lung(4)	6						CCAGCTGCCTCCCCGCCAACA	0.652000													3	15					0	0	1	0	0
ARRDC2	27106	broad.mit.edu	37	19	18121442	18121442	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:18121442C>T	ENST00000222250.4	+	7	1217	c.1074C>T	c.(1072-1074)ccC>ccT	p.P358P	ARRDC2_ENST00000379656.2_Silent_p.P353P	NM_015683.1	NP_056498.1	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2	358										endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)	12						GGCAGAGCCCCTTCCCGCTTC	0.632000													37	78					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60689058	60689058	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:60689058G>A	ENST00000335712.6	-	4	1216	c.989C>T	c.(988-990)cCg>cTg	p.P330L	BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Missense_Mutation_p.P296L|BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000358510.4_Missense_Mutation_p.P296L|BCL11A_ENST00000356842.4_Missense_Mutation_p.P330L	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	330	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGGGGACAGCGGTGGGCTAGA	0.612000			T	IGH@	B-CLL								57	138					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202266700	202266700	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:202266700G>A	ENST00000367278.3	+	7	870	c.781G>A	c.(781-783)Gaa>Aaa	p.E261K	LGR6_ENST00000439764.2_Missense_Mutation_p.E122K|LGR6_ENST00000308543.3_3'UTR|LGR6_ENST00000255432.7_Missense_Mutation_p.E209K	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	261						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						CAGACTGCAGGAACTGTAAGC	0.557000													30	81					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31150654	31150654	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31150654C>T	ENST00000268281.4	-	15	2431	c.2373G>A	c.(2371-2373)gaG>gaA	p.E791E	PRSS36_ENST00000569305.1_Silent_p.E786E|PRSS36_ENST00000418068.2_Silent_p.E688E	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	791	Peptidase S1 3.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						CAGCAAACAGCTCCCGGCTCC	0.632000													8	56					0	0	1	0	0
LRIT2	340745	broad.mit.edu	37	10	85984599	85984599	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:85984599G>A	ENST00000372113.4	-	2	387	c.382C>T	c.(382-384)Ctc>Ttc	p.L128F	LRIT2_ENST00000538192.1_Missense_Mutation_p.L128F	NM_001017924.2	NP_001017924.1	A6NDA9	LRIT2_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 2	128						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|prostate(6)|urinary_tract(1)	32						ACCCTCAGGAGAGGGGTGGCA	0.557000													43	124					0	0	1	0	0
OR2F1	26211	broad.mit.edu	37	7	143657918	143657918	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:143657918G>A	ENST00000392899.1	+	1	892	c.855G>A	c.(853-855)ctG>ctA	p.L285L		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					CACCAATGCTGAACCCCATGA	0.453000													21	103					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148463635	148463635	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:148463635C>T	ENST00000324300.5	+	8	1664	c.1149C>T	c.(1147-1149)tgC>tgT	p.C383C	EDNRA_ENST00000503721.1_3'UTR|EDNRA_ENST00000506066.1_Silent_p.C274C|EDNRA_ENST00000339690.5_3'UTR|EDNRA_ENST00000358556.4_Silent_p.C274C|EDNRA_ENST00000511804.1_Silent_p.C158C	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	383					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CCCAGTCATGCCTCTGCTGCT	0.547000													23	76					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49428229	49428229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49428229G>A	ENST00000301067.7	-	37	10470	c.10471C>T	c.(10471-10473)Cgt>Tgt	p.R3491C		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGGTTGGGACGAGGCTGGGAG	0.587000													9	12					0	0	1	0	0
GTF3C6	112495	broad.mit.edu	37	6	111283616	111283616	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:111283616A>T	ENST00000329970.7	+	5	479	c.269A>T	c.(268-270)aAa>aTa	p.K90I	GTF3C6_ENST00000480191.1_3'UTR	NM_138408.3	NP_612417.1	Q969F1	TF3C6_HUMAN	general transcription factor IIIC, polypeptide 6, alpha 35kDa	90						transcription factor TFIIIC complex	DNA binding|protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)	4		all_cancers(87;0.00328)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|Colorectal(196;0.0466)|all_epithelial(87;0.0575)		OV - Ovarian serous cystadenocarcinoma(136;0.105)|all cancers(137;0.179)|Epithelial(106;0.186)		GGCAATAATAAAACAGTGCTA	0.348000													12	16					0	0	1	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709191	128709191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:128709191C>T	ENST00000392665.2	-	2	1092	c.948G>A	c.(946-948)ggG>ggA	p.G316G	KCNJ1_ENST00000392666.1_Silent_p.G316G|KCNJ1_ENST00000440599.2_Silent_p.G316G|KCNJ1_ENST00000324036.3_Silent_p.G316G|KCNJ1_ENST00000392664.2_Silent_p.G335G	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	335					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity	p.G335G(1)		breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CTCGGTATTTCCCTTCCTTTG	0.493000													26	60					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648104	130648104	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:130648104C>T	ENST00000229030.4	+	1	1101	c.617C>T	c.(616-618)tCg>tTg	p.S206L	FZD10_ENST00000539839.1_Silent_p.V173V			Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	206					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		AAGAGCGCGTCGTGCGCGCCG	0.726000													4	22					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58491150	58491150	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:58491150G>A	ENST00000341164.4	-	7	1518	c.898C>T	c.(898-900)Cat>Tat	p.H300Y	ZNF606_ENST00000536132.1_Missense_Mutation_p.H210Y	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TGTATTATATGATTGAAAGAT	0.318000													22	64					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48538680	48538680	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:48538680C>T	ENST00000427954.2	+	4	520	c.477C>T	c.(475-477)tcC>tcT	p.S159S	ACSF2_ENST00000504392.1_Intron|ACSF2_ENST00000541920.1_Intron|ACSF2_ENST00000300441.4_Silent_p.S134S|ACSF2_ENST00000502667.1_Silent_p.S134S			Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	134					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GACCTAACTCCTATGCATGGG	0.587000													12	23					0	0	1	0	0
IGHV1-8	28472	broad.mit.edu	37	14	106539304	106539304	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:106539304C>T	ENST00000390599.2	-	0	187																											ATCCAGAAGCCTTGCAGGAGA	0.562000													75	40					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183913377	183913377	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:183913377C>T	ENST00000361927.4	-	10	1721	c.1350G>A	c.(1348-1350)atG>atA	p.M450I	COLGALT2_ENST00000367521.1_Missense_Mutation_p.M58I|COLGALT2_ENST00000367520.3_Missense_Mutation_p.M187I|COLGALT2_ENST00000546159.1_Missense_Mutation_p.M450I	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		CCATCAGCTTCATCAGCTTCT	0.453000													27	85					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124989729	124989729	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:124989729C>T	ENST00000522917.1	+	10	1149	c.943C>T	c.(943-945)Cct>Tct	p.P315S	FER1L6_ENST00000399018.1_Missense_Mutation_p.P315S	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	315	C2 2.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGAAATGTTCCCTCCCTTGTG	0.498000													33	83					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106846214	106846214	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:106846214G>A	ENST00000276185.4	+	16	5044	c.5044G>A	c.(5044-5046)Gac>Aac	p.D1682N				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1682						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GGCCAATGTGGACAAGAGCCC	0.587000													21	19					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42162048	42162048	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:42162048C>T	ENST00000444063.1	+	10	1365	c.1233C>T	c.(1231-1233)acC>acT	p.T411T	L3MBTL1_ENST00000373134.1_Silent_p.T411T|L3MBTL1_ENST00000418998.1_Silent_p.T479T|L3MBTL1_ENST00000373135.3_Silent_p.T411T|L3MBTL1_ENST00000427442.2_Silent_p.T479T			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	411					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						AGCCCCTCACCCCTCCACAAG	0.592000													14	62					0	0	1	0	0
AKR1C3	8644	broad.mit.edu	37	10	5141002	5141002	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:5141002G>A	ENST00000380554.3	+	4	1030	c.378G>A	c.(376-378)gaG>gaA	p.E126E	AKR1C3_ENST00000605149.1_Silent_p.E103E|AKR1C3_ENST00000439082.2_Silent_p.E7E	NM_001253908.1|NM_003739.5	NP_001240837.1|NP_003730.4	P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3	126					prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	AGCCAGGTGAGGAACTTTCAC	0.428000													15	44					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79060533	79060533	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79060533G>A	ENST00000388820.4	-	17	2797	c.2587C>T	c.(2587-2589)Ccc>Tcc	p.P863S	ADAMTS7_ENST00000566303.1_5'UTR	NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	863	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CGGCCCAGGGGGTCACAGTGC	0.697000													10	11					0	0	1	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33877622	33877622	+	Silent	SNP	C	C	G	rs143026467		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:33877622C>G	ENST00000307296.3	+	8	1298	c.921C>G	c.(919-921)gcC>gcG	p.A307A	PDCD6IP_ENST00000457054.2_Silent_p.A312A			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	307	BRO1.|Interaction with CHMP4A, CHMP4B and CHMP4C.|Interaction with EIAV p9.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						TCAATCGTGCCCTTGCTGCAG	0.373000													63	145					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43279991	43279991	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:43279991C>T	ENST00000374518.4	+	2	212	c.149C>T	c.(148-150)gCt>gTt	p.A50V		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	50					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GTTCAGTCTGCTGTGCGGATG	0.468000													33	123					0	0	1	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37964342	37964342	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:37964342C>T	ENST00000249014.4	+	3	1111	c.691C>T	c.(691-693)Ccc>Tcc	p.P231S		NM_152243.2	NP_689449.1	Q00587	BORG5_HUMAN	CDC42 effector protein (Rho GTPase binding) 1	231	8 X 7 AA tandem repeats of [PT]-[AT]-A- [ENT]-[PT]-[PTS]-[AG].				positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(4)|prostate(5)	15	Melanoma(58;0.0574)					CGCTGCAAACCCCCCAGCCCC	0.672000													12	33					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41550893	41550893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41550893C>T	ENST00000400454.1	-	15	3385	c.2908G>A	c.(2908-2910)Gag>Aag	p.E970K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	970	Fibronectin type-III 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTGCTGGGCTCGCTCTTGCCA	0.602000													16	47					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36714350	36714350	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:36714350G>A	ENST00000216181.5	-	11	1359	c.1129C>T	c.(1129-1131)Ctc>Ttc	p.L377F		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	377	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						ATACCCAAGAGATGGGACACC	0.473000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				100	228					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153765949	153765949	+	Silent	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:153765949T>C	ENST00000297107.6	+	7	1152	c.1015T>C	c.(1015-1017)Ttg>Ctg	p.L339L	GALNT10_ENST00000425427.2_Silent_p.L339L|GALNT10_ENST00000519544.1_3'UTR|GALNT10_ENST00000377661.2_Silent_p.L277L|SAP30L-AS1_ENST00000519727.1_RNA	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	339	Catalytic subdomain B.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			TGACCCAGGCTTGGAGATCTG	0.592000													39	87					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125876306	125876306	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:125876306C>T	ENST00000393434.2	-	4	757	c.408G>A	c.(406-408)tgG>tgA	p.W136*	ALDH1L1_ENST00000273450.3_Nonsense_Mutation_p.W146*|ALDH1L1_ENST00000393431.2_Nonsense_Mutation_p.W136*|ALDH1L1_ENST00000472186.1_Nonsense_Mutation_p.W136*|ALDH1L1_ENST00000452905.2_Intron|ALDH1L1_ENST00000455064.2_5'UTR	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	136	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CATCATCCGCCCAGAAGATGG	0.572000													30	110					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88379792	88379792	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:88379792G>A	ENST00000298699.2	-	11	1141	c.961C>T	c.(961-963)Cac>Tac	p.H321Y	C12orf50_ENST00000550553.1_Missense_Mutation_p.H282Y	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	321										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						TTATTGCGGTGATAACTCATT	0.453000													10	121					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119942902	119942902	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:119942902G>A	ENST00000327554.2	+	7	1142	c.677G>A	c.(676-678)cGa>cAa	p.R226Q	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	226										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CCCACAATGCGAGTCACCAAC	0.517000													30	116					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152883916	152883916	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152883916C>T	ENST00000368764.3	+	2	1707	c.1643C>T	c.(1642-1644)gCt>gTt	p.A548V	IVL_ENST00000392667.2_Missense_Mutation_p.A402V			P07476	INVO_HUMAN	involucrin	548					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTTGCCCCAGCTCCAGGCCAG	0.592000													16	42					0	0	1	0	0
FNDC4	64838	broad.mit.edu	37	2	27716878	27716878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27716878C>T	ENST00000264703.3	-	4	764	c.373G>A	c.(373-375)Gga>Aga	p.G125R		NM_022823.2	NP_073734.1	Q9H6D8	FNDC4_HUMAN	fibronectin type III domain containing 4	125	Fibronectin type-III.					integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|prostate(1)|skin(1)	9	Acute lymphoblastic leukemia(172;0.155)					GGACTCTCTCCCCGAAGGCCG	0.607000													17	85					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123755273	123755273	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:123755273C>T	ENST00000375026.2	-	2	468	c.252G>A	c.(250-252)ctG>ctA	p.L84L		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	84						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						ATTTCATACCCAGGATTAAGT	0.423000													34	67					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20634826	20634826	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20634826C>T	ENST00000219151.4	-	14	1879	c.669G>A	c.(667-669)aaG>aaA	p.K223K	ACSM1_ENST00000520010.1_Silent_p.K572K|ACSM1_ENST00000307493.4_Silent_p.K572K			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	572					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						GACCAGTCTCCTTTTTCCGAA	0.493000													17	67					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44477369	44477369	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:44477369G>A	ENST00000360584.2	-	2	304	c.113C>T	c.(112-114)tCc>tTc	p.S38F	SLC6A9_ENST00000372307.3_Intron|SLC6A9_ENST00000372310.3_Intron|SLC6A9_ENST00000357730.2_Intron|SLC6A9_ENST00000372306.3_Intron|SLC6A9_ENST00000492434.2_Intron|SLC6A9_ENST00000475075.2_Intron|SLC6A9_ENST00000537678.1_Intron	NM_201649.3	NP_964012.2	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	38						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CAGGAAGAAGGATCTCTGAAC	0.597000													13	43					0	0	1	0	0
BVES	11149	broad.mit.edu	37	6	105549067	105549067	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:105549067C>T	ENST00000314641.5	-	8	1196	c.980G>A	c.(979-981)cGa>cAa	p.R327Q	BVES_ENST00000446408.2_Missense_Mutation_p.R327Q|BVES_ENST00000336775.5_Missense_Mutation_p.R327Q	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	327					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity			NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				GGCAGAGGCTCGCTGGTGTGG	0.448000													16	28					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12618853	12618853	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:12618853G>A	ENST00000425538.1	+	3	339	c.139G>A	c.(139-141)Gaa>Aaa	p.E47K	MYOCD_ENST00000343344.4_Missense_Mutation_p.E47K	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	47					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACGTCCAGCTGAATTCCATGA	0.418000													20	26					0	0	1	0	0
IL2	3558	broad.mit.edu	37	4	123374864	123374864	+	Splice_Site	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:123374864C>T	ENST00000226730.4	-	3	636		c.e3+1			NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2						anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		TAATGCCTTACCTTTAGTTCC	0.338000			T	TNFRSF17	intestinal T-cell lymphoma								22	104					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9098546	9098546	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9098546G>A	ENST00000377424.4	-	10	1297	c.1118C>T	c.(1117-1119)cCa>cTa	p.P373L	SLC2A5_ENST00000535586.1_Missense_Mutation_p.P258L|SLC2A5_ENST00000536305.1_Missense_Mutation_p.P314L	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	373					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGATGTATGGCATCCAGGA	0.607000													10	17					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31541393	31541393	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:31541393C>T	ENST00000454783.1	+	4	799	c.541C>T	c.(541-543)Cta>Tta	p.L181L	LTA_ENST00000418386.2_Silent_p.L181L	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	181					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	GGGAGACCAGCTATCCACCCA	0.557000													64	222					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49663135	49663135	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:49663135G>A	ENST00000249601.4	-	6	998	c.702C>T	c.(700-702)taC>taT	p.Y234Y	ARHGAP22_ENST00000435790.2_Silent_p.Y240Y|ARHGAP22_ENST00000374170.1_Intron|ARHGAP22_ENST00000374172.1_Silent_p.Y125Y|ARHGAP22_ENST00000417247.2_Silent_p.Y144Y|ARHGAP22_ENST00000417912.2_Silent_p.Y250Y	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	234	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GCTCCCGCAGGTACAGCTTCA	0.662000													7	24					0	0	1	0	0
PAXBP1	94104	broad.mit.edu	37	21	34123226	34123226	+	Splice_Site	SNP	A	A	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:34123226A>G	ENST00000331923.4	-	10	1913		c.e10+1		PAXBP1_ENST00000290178.4_Splice_Site	NM_016631.3	NP_057715.2			PAX3 and PAX7 binding protein 1																		TAAATGTCTAACCTTTTTCCA	0.358000													31	58					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54967229	54967229	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:54967229G>A	ENST00000243052.3	+	9	1363	c.927G>A	c.(925-927)atG>atA	p.M309I	PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000538346.1_Missense_Mutation_p.M268I|PDE1B_ENST00000550620.1_Missense_Mutation_p.M289I	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	309	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						ATGATGAGATGAACATTTTCA	0.453000													17	73					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26906074	26906074	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:26906074G>A	ENST00000231021.4	-	5	977	c.805C>T	c.(805-807)Ccc>Tcc	p.P269S		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	269	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTACTCTGGGGAAATCGAGGA	0.428000													56	171					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23866398	23866398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:23866398G>A	ENST00000405093.3	-	17	2101	c.2031C>T	c.(2029-2031)ccC>ccT	p.P677P	MYH6_ENST00000356287.3_Silent_p.P677P	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	677	Actin-binding.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCCGCTCATTGGGGATGATGC	0.552000													60	127					0	0	1	0	0
TM4SF4	7104	broad.mit.edu	37	3	149205458	149205458	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:149205458C>T	ENST00000305354.4	+	3	1221	c.317C>T	c.(316-318)tCg>tTg	p.S106L		NM_004617.3	NP_004608.1	P48230	T4S4_HUMAN	transmembrane 4 L six family member 4	106						integral to membrane				large_intestine(3)|lung(4)|ovary(1)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCTGGATACTCGTTTATCATC	0.502000													7	76					0	0	1	0	0
BARHL2	343472	broad.mit.edu	37	1	91177971	91177971	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:91177971C>T	ENST00000370445.4	-	3	1103	c.1062G>A	c.(1060-1062)cgG>cgA	p.R354R		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	354						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		GCACCAGGGGCCGCTGCAGCT	0.687000													4	11					0	0	1	0	0
PEX14	5195	broad.mit.edu	37	1	10689751	10689751	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:10689751C>T	ENST00000356607.4	+	9	921	c.841C>T	c.(841-843)Cac>Tac	p.H281Y	PEX14_ENST00000538836.1_Missense_Mutation_p.H217Y	NM_004565.2	NP_004556.1	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	281					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(3)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	13	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		GAAGGAGGGCCACAGCCCCGA	0.677000													7	16					0	0	1	0	0
FKBP9L	360132	broad.mit.edu	37	7	55755519	55755519	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:55755519C>T	ENST00000455909.1	-	0	487					NR_027340.1|NR_027342.1				FK506 binding protein 9-like											endometrium(1)|kidney(1)|lung(3)	5						GATCACTGTCCGTTTCTCGCC	0.517000													18	58					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207850802	207850802	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:207850802C>T	ENST00000508064.2	+	2	226	c.166C>T	c.(166-168)Ccc>Tcc	p.P56S	CR1L_ENST00000530905.1_3'UTR	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	56	Sushi 1.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CTTTGAGTTTCCCATTGGGAC	0.468000													41	126					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48391447	48391447	+	Missense_Mutation	SNP	G	G	A	rs1050861		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:48391447G>A	ENST00000380518.3	-	7	637	c.473C>T	c.(472-474)cCt>cTt	p.P158L	COL2A1_ENST00000337299.6_Missense_Mutation_p.P89L	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	158			P -> L (in dbSNP:rs1050861).		axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	aggATTTCCAGGGGTCCCAGG	0.582000													20	64					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186338496	186338496	+	Missense_Mutation	SNP	C	C	T	rs145128363		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:186338496C>T	ENST00000411641.2	+	7	1100	c.881C>T	c.(880-882)cCc>cTc	p.P294L	AHSG_ENST00000273784.5_Missense_Mutation_p.P295L			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	294					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GCTGGCTCACCCCCAGACTCC	0.637000													39	179					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6167147	6167147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6167147C>T	ENST00000261405.5	-	14	1851	c.1597G>A	c.(1597-1599)Gac>Aac	p.D533N		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	533	VWFD 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AGGAAGTCGTCGCCCTGGTTG	0.662000													34	86					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108013806	108013806	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:108013806C>T	ENST00000280758.5	+	11	3024	c.2496C>T	c.(2494-2496)atC>atT	p.I832I	BTBD11_ENST00000357167.4_Silent_p.I369I|BTBD11_ENST00000420571.2_Silent_p.I713I|BTBD11_ENST00000490090.2_Silent_p.I832I	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	832						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CTTTGCGGATCGCCTTCCAGC	0.607000													5	30					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49176534	49176534	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:49176534G>A	ENST00000307885.4	-	1	1378	c.684C>T	c.(682-684)ctC>ctT	p.L228L	ADCY6_ENST00000357869.3_Silent_p.L228L|ADCY6_ENST00000550422.1_Silent_p.L228L	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	228					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GGTCTGCTGCGAGAGCGCCCC	0.667000													3	11					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17774359	17774359	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:17774359C>T	ENST00000428389.2	-	9	804	c.805G>A	c.(805-807)Ggc>Agc	p.G269S	UNC13A_ENST00000552293.1_Missense_Mutation_p.G181S|UNC13A_ENST00000519716.2_Missense_Mutation_p.G181S|UNC13A_ENST00000551649.1_Missense_Mutation_p.G181S|UNC13A_ENST00000550896.1_Missense_Mutation_p.G181S|UNC13A_ENST00000252773.7_Missense_Mutation_p.G181S			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	181					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						TCACCCCAGCCAAAATAATTC	0.537000													3	17					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71940997	71940997	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:71940997C>T	ENST00000298229.2	+	8	1077	c.873C>T	c.(871-873)tcC>tcT	p.S291S	INPPL1_ENST00000538751.1_Silent_p.S49S|INPPL1_ENST00000541756.1_Silent_p.S49S	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	291					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						ACATGAGCTCCACAGCACCCC	0.642000													9	55					0	0	1	0	0
DPYSL2	1808	broad.mit.edu	37	8	26435788	26435788	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:26435788G>A	ENST00000311151.5	+	1	430	c.18G>A	c.(16-18)aaG>aaA	p.K6K	DPYSL2_ENST00000521913.1_Intron	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	6					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		ATCAGGGGAAGAAAAATATTC	0.433000													27	104					0	0	1	0	0
TNFRSF4	7293	broad.mit.edu	37	1	1149139	1149139	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:1149139G>A	ENST00000379236.3	-	2	176	c.172C>T	c.(172-174)Cgc>Tgc	p.R58C		NM_003327.3	NP_003318.1	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily, member 4	58					immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity			large_intestine(1)|lung(2)|urinary_tract(1)	4	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTCTGGGAGCGGCTGCAGCGG	0.697000													8	13					0	0	1	0	0
NUP37	79023	broad.mit.edu	37	12	102471194	102471194	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:102471194G>A	ENST00000552283.1	-	7	767	c.628C>T	c.(628-630)Cca>Tca	p.P210S	NUP37_ENST00000251074.1_Missense_Mutation_p.P210S			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	210					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						GACATTAATGGCACTTGTTCT	0.403000													50	70					0	0	1	0	0
STPG1	90529	broad.mit.edu	37	1	24706163	24706163	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24706163G>A	ENST00000374409.1	-	5	696	c.442C>T	c.(442-444)Cct>Tct	p.P148S	STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000337248.4_Missense_Mutation_p.P148S|STPG1_ENST00000440416.1_Missense_Mutation_p.P101S|STPG1_ENST00000003583.8_Missense_Mutation_p.P101S	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		TTTGGTGCAGGAGTTTCAAAC	0.383000													29	172					0	0	1	0	0
EBF2	64641	broad.mit.edu	37	8	25718726	25718726	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:25718726C>T	ENST00000520164.1	-	13	1718	c.1181G>A	c.(1180-1182)cGa>cAa	p.R394Q	EBF2_ENST00000535548.1_Missense_Mutation_p.R125Q|EBF2_ENST00000408929.3_Missense_Mutation_p.R246Q	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	394					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GTCTGCGGCTCGCTTCAAAAT	0.488000													35	68					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388446	48388446	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:48388446G>A	ENST00000224600.4	-	1	2545	c.2432C>T	c.(2431-2433)tCt>tTt	p.S811F		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	811	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GTCAAAGACAGAATACAGGTG	0.607000													9	14					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9082364	9082364	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9082364G>A	ENST00000397910.4	-	1	9654	c.9451C>T	c.(9451-9453)Cct>Tct	p.P3151S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3152	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTTGGCAGGAACTGAAATA	0.443000													24	66					0	0	1	0	0
NUBP1	4682	broad.mit.edu	37	16	10850585	10850585	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:10850585C>T	ENST00000283027.5	+	6	418	c.399C>T	c.(397-399)ttC>ttT	p.F133F	NUBP1_ENST00000571790.1_3'UTR|NUBP1_ENST00000433392.2_Silent_p.F122F	NM_002484.2	NP_002475.2	P53384	NUBP1_HUMAN	nucleotide binding protein 1	133					cell growth|cellular iron ion homeostasis|iron-sulfur cluster assembly	cytosol	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|nucleoside-triphosphatase activity|protein binding			large_intestine(2)|lung(3)|ovary(1)|skin(4)	10						CAGTGGGCTTCCTGCTCAGCA	0.527000													6	61					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17446114	17446114	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17446114C>T	ENST00000400588.1	-	7	1440	c.1333G>A	c.(1333-1335)Gag>Aag	p.E445K		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	445										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AAGGAGAGCTCATTGATGACC	0.567000													8	40					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411151	126411151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:126411151C>T	ENST00000394329.3	+	17	13187	c.13174C>T	c.(13174-13176)Ccc>Tcc	p.P4392S	FAT4_ENST00000335110.5_Missense_Mutation_p.P2633S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4392	Laminin G-like 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AAAAACAGATCCCTCAGTGAA	0.512000													104	243					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60695126	60695126	+	Missense_Mutation	SNP	G	G	A	rs144704995	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:60695126G>A	ENST00000005286.4	+	3	482	c.329G>A	c.(328-330)cGa>cAa	p.R110Q	TMEM132A_ENST00000453848.2_Missense_Mutation_p.R110Q	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	110						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GTCCCCCCTCGAGTCACTGAG	0.602000													78	168					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53157793	53157793	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:53157793G>A	ENST00000296292.3	-	3	274	c.213C>T	c.(211-213)ctC>ctT	p.L71L	RFT1_ENST00000394738.3_Intron	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	71					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		TGCCCCCACTGAGACATGCTC	0.537000													19	46					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184765166	184765166	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:184765166C>T	ENST00000367511.3	-	14	1925	c.1732G>A	c.(1732-1734)Gaa>Aaa	p.E578K	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	578					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GACACACTTTCACTGGGCAAG	0.463000													24	97					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520398	131520398	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:131520398G>A	ENST00000423981.1	+	2	863	c.753G>A	c.(751-753)ggG>ggA	p.G251G	AMER3_ENST00000321420.4_Silent_p.G251G	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		CGGGTTGTGGGGAGGTGTTCG	0.637000													29	79					0	0	1	0	0
IGHV3-66	28412	broad.mit.edu	37	14	107131123	107131123	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:107131123G>A	ENST00000390632.2	-	0	336																											TGGAGATGGTGAATCGGCCCT	0.527000													24	201					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34181935	34181935	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34181935G>A	ENST00000373381.4	-	20	3344	c.3168C>T	c.(3166-3168)ttC>ttT	p.F1056F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1016	Sushi 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AATCAGAGATGAAGCGGACCT	0.542000													9	67					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832380	61832380	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:61832380C>T	ENST00000280772.1	-	37	8450	c.8259G>A	c.(8257-8259)gaG>gaA	p.E2753E	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2753					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTAGCTTGCTCTCCTGTATTT	0.403000													48	132					0	0	1	0	0
FOXK1	221937	broad.mit.edu	37	7	4798696	4798696	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4798696C>T	ENST00000328914.4	+	6	1259	c.1259C>T	c.(1258-1260)tCg>tTg	p.S420L	FOXK1_ENST00000446823.1_Missense_Mutation_p.S257L	NM_001037165.1	NP_001032242.1	P85037	FOXK1_HUMAN	forkhead box K1	420					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		GCTCCAGCTTCGCCCACACAC	0.682000													37	80					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19492780	19492780	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:19492780C>T	ENST00000328405.2	+	10	1975	c.1709C>T	c.(1708-1710)tCt>tTt	p.S570F	KCNH8_ENST00000537696.1_3'UTR	NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	570						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						ATCAAAACCTCTTTCTGTGCT	0.502000													39	83					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55880415	55880415	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:55880415G>A	ENST00000521992.1	-	14	1908	c.1763C>T	c.(1762-1764)tCc>tTc	p.S588F	CES5A_ENST00000319165.9_Missense_Mutation_p.S509F|CES5A_ENST00000290567.9_Missense_Mutation_p.S559F|CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000520435.1_Missense_Mutation_p.S529F|CES5A_ENST00000518005.1_Missense_Mutation_p.S453F	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	559						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GAAAGTTAAGGAAGAAAGAGG	0.483000													51	153					0	0	1	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73142151	73142151	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:73142151C>T	ENST00000545377.1	+	12	1662	c.1486C>T	c.(1486-1488)Cac>Tac	p.H496Y	ARHGEF28_ENST00000426542.2_Missense_Mutation_p.H496Y|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.H496Y|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.H496Y|ARHGEF28_ENST00000513841.1_3'UTR|ARHGEF28_ENST00000287898.5_Missense_Mutation_p.H496Y|ARHGEF28_ENST00000296799.4_Missense_Mutation_p.H183Y|ARHGEF28_ENST00000296794.6_Missense_Mutation_p.H496Y	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		TGAGCCATCCCACATCTGTTA	0.483000													14	44					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228860316	228860316	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228860316C>T	ENST00000392056.3	-	8	4589	c.4543G>A	c.(4543-4545)Gag>Aag	p.E1515K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E1515K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1515						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CCTGTGCTCTCCTCGCTGCTG	0.572000													52	92					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114136163	114136163	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:114136163C>T	ENST00000356116.1	+	1	208	c.96C>T	c.(94-96)agC>agT	p.S32S	ACSL5_ENST00000354273.4_5'UTR|ACSL5_ENST00000433418.1_5'UTR|ACSL5_ENST00000354655.4_Intron|ACSL5_ENST00000479936.1_Intron|ACSL5_ENST00000393081.1_Intron	NM_016234.3	NP_057318.2	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	0					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		AGCCGGGAAGCCCCCATTCAC	0.602000													15	108					0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3140824	3140824	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:3140824G>A	ENST00000263650.7	-	7	803	c.644C>T	c.(643-645)cCc>cTc	p.P215L	OSBPL5_ENST00000389989.3_Missense_Mutation_p.P147L|OSBPL5_ENST00000348039.5_Missense_Mutation_p.P147L|OSBPL5_ENST00000525498.1_Missense_Mutation_p.P126L|OSBPL5_ENST00000542243.1_Intron	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	215	PH.				cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GCTGGGCAGGGGCTGTGTGAT	0.642000													32	58					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101671417	101671417	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:101671417C>T	ENST00000360264.3	+	3	234	c.214C>T	c.(214-216)Caa>Taa	p.Q72*	CUX1_ENST00000550008.2_Nonsense_Mutation_p.Q61*|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000556210.1_Nonsense_Mutation_p.Q61*|CUX1_ENST00000292538.4_Nonsense_Mutation_p.Q72*|CUX1_ENST00000425244.2_Nonsense_Mutation_p.Q72*|CUX1_ENST00000549414.2_Nonsense_Mutation_p.Q61*|CUX1_ENST00000437600.4_Nonsense_Mutation_p.Q72*|CUX1_ENST00000393824.3_Nonsense_Mutation_p.Q35*|CUX1_ENST00000292535.7_Nonsense_Mutation_p.Q61*|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Nonsense_Mutation_p.Q61*	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	61					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						GAAGAGTTTCCAAGGAGAGGT	0.473000													7	73					0	0	1	0	0
KRT83	3889	broad.mit.edu	37	12	52710324	52710324	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:52710324G>A	ENST00000293670.3	-	6	1031	c.969C>T	c.(967-969)acC>acT	p.T323T		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	323	Coil 2.|Rod.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTCCTCCTTGGTGCGGCGCA	0.597000													7	80					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108782046	108782046	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108782046C>T	ENST00000232603.5	-	10	930	c.848G>A	c.(847-849)gGa>gAa	p.G283E	MORC1_ENST00000483760.1_Missense_Mutation_p.G283E	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	283					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTTAAATGCTCCTTTAAAAGA	0.303000													15	101					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178846735	178846735	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:178846735G>A	ENST00000367635.3	+	9	1048	c.710G>A	c.(709-711)cGa>cAa	p.R237Q	RALGPS2_ENST00000477383.1_3'UTR|RALGPS2_ENST00000367634.2_Missense_Mutation_p.R237Q|RALGPS2_ENST00000324778.4_Missense_Mutation_p.R202Q	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	237	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						AATATCCTTCGAATAATTTCT	0.333000													13	46					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47400212	47400212	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:47400212C>T	ENST00000457840.2	-	6	646	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	CYP4A11_ENST00000371904.4_Silent_p.R271R|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371905.1_Silent_p.R270R|CYP4A11_ENST00000310638.4_Silent_p.R270R			Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	0					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	GTTGAGCCTTCCTCAGTTGGA	0.532000													29	89					0	0	1	0	0
AGFG1	3267	broad.mit.edu	37	2	228399602	228399602	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228399602C>T	ENST00000310078.7	+	8	1326	c.1066C>T	c.(1066-1068)Cct>Tct	p.P356S	AGFG1_ENST00000409171.1_Missense_Mutation_p.P356S|AGFG1_ENST00000373671.3_Missense_Mutation_p.P316S|AGFG1_ENST00000409979.2_Missense_Mutation_p.P380S|AGFG1_ENST00000409315.1_Intron	NM_001135188.1|NM_004504.4	NP_001128660.1|NP_004495.2	P52594	AGFG1_HUMAN	ArfGAP with FG repeats 1	356					cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(2)|ovary(1)|prostate(1)|skin(4)|stomach(1)	18						AGGTAAAGCTCCTGTTGGTTC	0.448000													30	90					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48201473	48201473	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:48201473G>A	ENST00000394747.1	-	28	4339	c.3990C>T	c.(3988-3990)ctC>ctT	p.L1330L	ABCC11_ENST00000353782.5_Silent_p.L1292L|ABCC11_ENST00000394748.1_Silent_p.L1330L|ABCC11_ENST00000356608.2_Silent_p.L1330L|ABCC11_ENST00000565329.1_5'UTR	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1330	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GGGCAATGACGAGCACGGTGC	0.567000													35	83					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965699	35965699	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35965699G>A	ENST00000274278.3	-	4	989	c.632C>T	c.(631-633)tCc>tTc	p.S211F	UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000507113.1_Missense_Mutation_p.S177F|UGT3A1_ENST00000503189.1_Missense_Mutation_p.S211F|UGT3A1_ENST00000333811.4_Missense_Mutation_p.S157F	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	211						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGGCTCCTGGAGAAACTAAA	0.463000													45	79					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76939021	76939021	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:76939021G>A	ENST00000373344.5	-	9	1941	c.1727C>T	c.(1726-1728)tCa>tTa	p.S576L	ATRX_ENST00000395603.3_Missense_Mutation_p.S538L|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	576					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TGTAGTTTTTGATTTAATACC	0.358000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						43	165					0	0	1	0	0
ACKR3	57007	broad.mit.edu	37	2	237489689	237489689	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:237489689C>T	ENST00000272928.3	+	2	891	c.581C>T	c.(580-582)aCc>aTc	p.T194I		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		AACAATGAGACCTACTGCCGG	0.587000													33	112					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161015120	161015120	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:161015120C>T	ENST00000447678.1	-	23	3619	c.3499G>A	c.(3499-3501)Gat>Aat	p.D1167N	LPA_ENST00000316300.5_Missense_Mutation_p.D1167N	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3675	Kringle 11.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGGTAGCAATCCTGGACCCCG	0.478000													43	69					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27699589	27699589	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:27699589G>A	ENST00000260570.3	-	14	1433	c.1330C>T	c.(1330-1332)Cgt>Tgt	p.R444C	IFT172_ENST00000416524.2_Missense_Mutation_p.R423C|IFT172_ENST00000359466.6_Missense_Mutation_p.R444C	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	444					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TCATTAATACGAACACTGAAA	0.373000													29	63					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967191	41967191	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:41967191C>T	ENST00000298919.7	+	10	2218	c.1830C>T	c.(1828-1830)ctC>ctT	p.L610L	PDZRN4_ENST00000402685.2_Silent_p.L870L|PDZRN4_ENST00000539469.2_Silent_p.L612L			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	870							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AGAGTCAGCTCAGCTTGGTGA	0.468000													49	95					0	0	1	0	0
HBBP1	3044	broad.mit.edu	37	11	5264417	5264417	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:5264417G>A	ENST00000454892.1	-	0	79					NR_001589.1																						GGTCATCCGTGAGCATAACAG	0.498000													7	27					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272026	52272026	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:52272026C>T	ENST00000598776.1	+	2	887	c.115C>T	c.(115-117)Ctc>Ttc	p.L39F	FPR2_ENST00000340023.6_Missense_Mutation_p.L39F|FPR2_ENST00000598953.1_Missense_Mutation_p.L39F	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	39					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity	p.L39F(1)		endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						CACCTTTGTCCTCGGGGTCCT	0.552000													23	77					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	71114247	71114247	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:71114247G>A	ENST00000396396.1	+	10	1813	c.1584G>A	c.(1582-1584)agG>agA	p.R528R		NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	528					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						GCTACGAGAGGGATCCCAGCG	0.577000													27	69					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114289764	114289764	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:114289764G>A	ENST00000309235.5	+	2	247	c.89G>A	c.(88-90)aGa>aAa	p.R30K	ZNF483_ENST00000358151.4_Missense_Mutation_p.R30K|ZNF483_ENST00000374374.3_Missense_Mutation_p.R30K|ZNF483_ENST00000355824.3_Missense_Mutation_p.R30K	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	30					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GAGGTCCCAAGAGTGGTTACT	0.458000													41	56					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134108468	134108468	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134108468C>T	ENST00000220616.4	+	43	7463	c.7423C>T	c.(7423-7425)Cct>Tct	p.P2475S	SLA_ENST00000518565.1_Intron|TG_ENST00000377869.1_Missense_Mutation_p.P2418S|TG_ENST00000519543.1_Missense_Mutation_p.P608S|TG_ENST00000542445.1_Missense_Mutation_p.P845S|SLA_ENST00000517648.1_Intron|SLA_ENST00000524345.1_Intron|SLA_ENST00000338087.5_Intron|SLA_ENST00000395352.3_Intron	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2475					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CGTGAGTGGCCCTTTCCACTA	0.502000													75	160					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418518	8418518	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:8418518G>A	ENST00000337907.3	-	21	4711	c.4077C>T	c.(4075-4077)gcC>gcT	p.A1359A	RERE_ENST00000377464.1_Silent_p.A1091A|RERE_ENST00000476556.1_Silent_p.A805A|RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Silent_p.A1359A	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1359					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGTGGGGCCCGGCGGTCGGGG	0.701000													4	15					0	0	1	0	0
KRT27	342574	broad.mit.edu	37	17	38935980	38935980	+	Missense_Mutation	SNP	C	C	A	rs76225348	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:38935980C>A	ENST00000301656.3	-	4	858	c.818G>T	c.(817-819)aGg>aTg	p.R273M		NM_181537.3	NP_853515.2	Q7Z3Y8	K1C27_HUMAN	keratin 27	273	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(3)|skin(1)|stomach(1)	21		Breast(137;0.000812)				CTCCGCGTCCCTGCGGTTCTG	0.642000													11	20					2.27111e-07	2.27728e-07	1	1	0
KIAA1024	23251	broad.mit.edu	37	15	79760663	79760663	+	Silent	SNP	C	C	T	rs151300850	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:79760663C>T	ENST00000305428.3	+	4	2763	c.2688C>T	c.(2686-2688)atC>atT	p.I896I		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	896						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						CTGCTCTGATCGCTGCTGCGG	0.458000													9	42					0	0	1	0	0
APBB3	10307	broad.mit.edu	37	5	139942061	139942061	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:139942061G>A	ENST00000357560.4	-	5	818	c.375C>T	c.(373-375)ggC>ggT	p.G125G	APBB3_ENST00000507279.1_5'UTR|APBB3_ENST00000412920.3_Silent_p.G125G|APBB3_ENST00000508496.2_5'UTR|APBB3_ENST00000358580.5_Silent_p.G125G|APBB3_ENST00000354402.5_Silent_p.G125G|APBB3_ENST00000511201.2_Silent_p.G125G|APBB3_ENST00000356738.2_Silent_p.G125G	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	125	PID 1.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCTACCCAGCCCAGAGAGC	0.572000													70	203					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34235552	34235552	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:34235552G>A	ENST00000587132.1	-	0	2475																											TTTGGGCTGAGATCAATACAT	0.478000													22	44					0	0	1	0	0
ZNF564	163050	broad.mit.edu	37	19	12639443	12639443	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:12639443G>A	ENST00000339282.7	-	2	267	c.71C>T	c.(70-72)tCc>tTc	p.S24F	ZNF709_ENST00000428311.1_Intron|CTD-2192J16.20_ENST00000593682.1_3'UTR	NM_144976.3	NP_659413.1			zinc finger protein 564											endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						TTTCTTCTGGGAAGGATCCAG	0.463000													51	124					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57136782	57136782	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:57136782C>T	ENST00000439986.4	-	4	360	c.323G>A	c.(322-324)cGa>cAa	p.R108Q	CCBE1_ENST00000398179.2_5'UTR	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	108					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				ACACAGCACTCGGCCAAAGTT	0.522000													52	111					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65396365	65396365	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:65396365C>T	ENST00000355703.3	+	24	4426	c.3887C>T	c.(3886-3888)gCc>gTc	p.A1296V		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1296						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CTAGGCAGTGCCGTCTTCATC	0.637000													11	23					0	0	1	0	0
WNT2B	7482	broad.mit.edu	37	1	113058976	113058976	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113058976G>A	ENST00000369684.4	+	3	1103	c.618G>A	c.(616-618)aaG>aaA	p.K206K	WNT2B_ENST00000256640.5_Silent_p.K114K|WNT2B_ENST00000478360.1_3'UTR|WNT2B_ENST00000369686.4_Silent_p.K187K	NM_024494.2	NP_078613.1	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B	206					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGATGCCAAGGAGAAGAGGC	0.537000													6	86					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46825915	46825915	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:46825915C>T	ENST00000283296.7	-	17	4013	c.3725G>A	c.(3724-3726)gGg>gAg	p.G1242E	GPR116_ENST00000265417.7_Missense_Mutation_p.G1242E|GPR116_ENST00000456426.2_Missense_Mutation_p.G1100E|GPR116_ENST00000362015.4_Missense_Mutation_p.G1242E|GPR116_ENST00000545669.1_Missense_Mutation_p.G671E	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1242					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			AAGGTTGGTCCCTGGGAACAC	0.488000													27	67					0	0	1	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42297140	42297140	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:42297140C>T	ENST00000399518.3	-	5	1048	c.562G>A	c.(562-564)Gag>Aag	p.E188K	PLA2G4E_ENST00000413860.2_Missense_Mutation_p.E159K	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	170					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		ACTCACCTCTCCTCCAGCAGG	0.622000													3	19					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78516338	78516338	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:78516338G>A	ENST00000278550.7	-	15	2640	c.2179_splice	c.e15+1	p.I726_splice		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TGCATTTACCGATAGAACAGT	0.552000													3	16					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35563557	35563557	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:35563557G>A	ENST00000262878.4	-	4	583	c.384C>T	c.(382-384)ctC>ctT	p.L128L	SAMHD1_ENST00000373694.5_5'UTR	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	128					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				GGAGAGGGTGGAGCTCAATGT	0.398000													37	77					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34164539	34164539	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:34164539C>T	ENST00000373381.4	-	24	3915	c.3739G>A	c.(3739-3741)Gaa>Aaa	p.E1247K	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.E120K	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1207	Sushi 7.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTGATGAGTTCAAAGCCTGGT	0.512000													4	39					0	0	1	0	0
DNMT1	1786	broad.mit.edu	37	19	10267156	10267156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:10267156G>A	ENST00000340748.4	-	17	1497	c.1262C>T	c.(1261-1263)cCc>cTc	p.P421L	DNMT1_ENST00000540357.1_Missense_Mutation_p.P421L|DNMT1_ENST00000359526.4_Missense_Mutation_p.P437L			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	421	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GGTGTCGATGGGACACAGGTG	0.473000													27	49					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21063133	21063133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:21063133G>A	ENST00000261383.3	-	29	4095	c.4096C>T	c.(4096-4098)Caa>Taa	p.Q1366*	DNAH3_ENST00000415178.1_Nonsense_Mutation_p.Q1366*	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1366	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GAGATCCATTGGAAATCATTC	0.527000													43	91					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17449880	17449880	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:17449880G>A	ENST00000302539.4	-	14	2121	c.1996C>T	c.(1996-1998)Ctg>Ttg	p.L666L	ABCC8_ENST00000389817.3_Silent_p.L666L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	666					carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTGGGGACCAGGCTCTGCAGT	0.657000													25	122					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45554637	45554637	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45554637C>T	ENST00000415258.1	+	15	1912	c.1771C>T	c.(1771-1773)Cat>Tat	p.H591Y	LARS2_ENST00000414984.1_Missense_Mutation_p.H548Y|LARS2_ENST00000467936.1_3'UTR|LARS2_ENST00000265537.3_Missense_Mutation_p.H591Y			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	591					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	GGAGCCTTTTCATAAGCTGCT	0.512000													15	154					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34502056	34502056	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:34502056C>T	ENST00000374012.3	+	12	1891	c.1762C>T	c.(1762-1764)Cat>Tat	p.H588Y	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	588					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GCCAGGGGTCCATATGAGCCC	0.537000													30	61					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	6031893	6031893	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6031893C>T	ENST00000356134.5	-	2	159	c.88G>A	c.(88-90)Gga>Aga	p.G30R	ANO2_ENST00000327087.8_Missense_Mutation_p.G30R|ANO2_ENST00000546188.1_Missense_Mutation_p.G30R	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	34						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CACTGCTGTCCATGTTTGGGG	0.662000													4	12					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423451	56423451	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:56423451C>T	ENST00000588751.1	-	5	1756	c.1732G>A	c.(1732-1734)Gaa>Aaa	p.E578K	NLRP13_ENST00000342929.3_Missense_Mutation_p.E578K			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	578							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAGTAGGCTTCTTTGTCAAGC	0.418000													43	108					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204335010	204335010	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:204335010G>A	ENST00000374493.3	-	5	839	c.840C>T	c.(838-840)tcC>tcT	p.S280S	RAPH1_ENST00000439222.1_Silent_p.S253S|RAPH1_ENST00000453034.1_Silent_p.S280S|RAPH1_ENST00000419464.1_Intron|RAPH1_ENST00000374489.2_Intron|RAPH1_ENST00000308091.4_Silent_p.S280S|RAPH1_ENST00000418114.1_Intron|RAPH1_ENST00000374488.2_Silent_p.S253S|RAPH1_ENST00000319170.5_Intron|RAPH1_ENST00000457812.1_Intron|RAPH1_ENST00000423104.1_Intron			Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	241	Ras-associating.				cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TCAGAAGAAGGGAGGTTTCCC	0.383000													34	113					0	0	1	0	0
POU2AF1	5450	broad.mit.edu	37	11	111229584	111229584	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:111229584C>T	ENST00000393067.3	-	2	590	c.76G>A	c.(76-78)Gag>Aag	p.E26K		NM_006235.2	NP_006226.2	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	26					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|kidney(2)|lung(2)	5		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		TTCACTGGCTCCTTCACACGG	0.632000			T	BCL6	NHL								10	33					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12954982	12954982	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:12954982G>A	ENST00000235347.4	-	3	380	c.301C>T	c.(301-303)Caa>Taa	p.Q101*		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	101										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCCAGCACTTGAAGTTTCCAC	0.527000													50	316					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186670720	186670720	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:186670720G>A	ENST00000343098.5	+	17	16954	c.16954G>A	c.(16954-16956)Gaa>Aaa	p.E5652K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E5563K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TAATAATAATGAAATTGAGAA	0.269000													29	68					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4281527	4281527	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:4281527C>T	ENST00000404826.2	+	43	6372	c.6233C>T	c.(6232-6234)tCc>tTc	p.S2078F	SDK1_ENST00000389531.3_Missense_Mutation_p.S2058F|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2078					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCACCTTCTCCAAGAAGAAC	0.632000													9	36					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159818882	159818882	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:159818882G>A	ENST00000497452.1	-	0	517																											gggagaaaacggagaagagtt	0.458000													116	368					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94671197	94671197	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:94671197C>T	ENST00000260526.6	-	6	735	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	ARHGAP29_ENST00000370217.3_Missense_Mutation_p.E185K	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	185					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTACCTTTTTCACTGGATGAG	0.323000													38	98					0	0	1	0	0
HCAR3	8843	broad.mit.edu	37	12	123200699	123200699	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:123200699C>T	ENST00000528880.2	-	1	740	c.586G>A	c.(586-588)Gag>Aag	p.E196K	HCAR1_ENST00000356987.2_Intron	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	196						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	AGGAAGAACTCCAGGAGGAAC	0.532000													22	78					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544533	186544533	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:186544533C>T	ENST00000431808.1	-	14	2601	c.2038G>A	c.(2038-2040)Gaa>Aaa	p.E680K	SORBS2_ENST00000498125.1_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000418609.1_Missense_Mutation_p.E584K|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000355634.5_Missense_Mutation_p.E780K|SORBS2_ENST00000284776.7_Missense_Mutation_p.E680K|SORBS2_ENST00000319471.9_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	680						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		TCGGTGTTTTCGTGTCTGGCT	0.522000													43	153					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9098032	9098032	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:9098032G>A	ENST00000377424.4	-	11	1405	c.1226C>T	c.(1225-1227)cCa>cTa	p.P409L	SLC2A5_ENST00000535586.1_Missense_Mutation_p.P294L|SLC2A5_ENST00000536305.1_Missense_Mutation_p.P350L	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	409					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGGCAGATGGCCGAGAGGA	0.647000													10	24					0	0	1	0	0
RHOV	171177	broad.mit.edu	37	15	41165381	41165381	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41165381C>T	ENST00000220507.4	-	3	735	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K		NM_133639.3	NP_598378.3	Q96L33	RHOV_HUMAN	ras homolog family member V	196					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding			central_nervous_system(1)|large_intestine(1)	2		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		TCAAATACTTCCTTCAAGTTC	0.592000													39	85					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730425	140730425	+	Missense_Mutation	SNP	G	G	A	rs36001111		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140730425G>A	ENST00000523390.1	+	1	598	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTAGACAGGGAACATCAGAG	0.493000													18	115					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25458674	25458674	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25458674C>T	ENST00000424208.1	+	0	2631				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						AGCCAGTTTCCCAGCCCCTGG	0.582000													9	18					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3777936	3777936	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3777936G>A	ENST00000262367.5	-	31	7921	c.7112C>T	c.(7111-7113)cCt>cTt	p.P2371L	CREBBP_ENST00000382070.3_Missense_Mutation_p.P2333L	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	2371					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGTGGCGAAGGCTGGGGCTG	0.642000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						10	90					0	0	1	0	0
DDB2	1643	broad.mit.edu	37	11	47256923	47256923	+	Missense_Mutation	SNP	C	C	T	rs145822896		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:47256923C>T	ENST00000256996.4	+	7	1178	c.983C>T	c.(982-984)cCg>cTg	p.P328L	DDB2_ENST00000378600.3_Intron|DDB2_ENST00000378601.3_3'UTR|DDB2_ENST00000378603.3_Missense_Mutation_p.P264L	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	328					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						GGCCTGATCCCGCACCCTCAC	0.622000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				23	35					0	0	1	0	0
PTPN6	5777	broad.mit.edu	37	12	7064026	7064026	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7064026G>A	ENST00000456013.1	+	4	627	c.385G>A	c.(385-387)Gag>Aag	p.E129K	PTPN6_ENST00000318974.9_Missense_Mutation_p.E129K|PTPN6_ENST00000399448.1_Missense_Mutation_p.E131K|PTPN6_ENST00000447931.2_Missense_Mutation_p.E90K	NM_080549.3	NP_536859.1	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type 6	129	SH2 2.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity	p.E129K(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|prostate(3)	18						GGCCAAGGGCGAGCCCTGGAC	0.637000													6	64					0	0	1	0	0
PRKY	5616	broad.mit.edu	37	Y	7239831	7239831	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:7239831C>T	ENST00000528056.1	+	0	1282					NR_028062.1															large_intestine(2)|lung(3)|skin(1)	6						CTTCCAACTTCGAAACTTACC	0.527000													14	8					0	0	1	0	0
XPNPEP3	63929	broad.mit.edu	37	22	41265035	41265035	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:41265035C>T	ENST00000357137.4	+	2	181	c.97C>T	c.(97-99)Ctt>Ttt	p.L33F	XPNPEP3_ENST00000414396.1_Missense_Mutation_p.L33F|XPNPEP3_ENST00000544094.1_Missense_Mutation_p.L10F|XPNPEP3_ENST00000541156.1_Missense_Mutation_p.L33F	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	33					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						AAGGTACTCCCTTCAGCCTGT	0.438000													56	111					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060569	9060569	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9060569G>A	ENST00000397910.4	-	3	27080	c.26877C>T	c.(26875-26877)ctC>ctT	p.L8959L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8961	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGCTCTGGGAGGCCTGGAT	0.463000													52	144					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20269523	20269523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:20269523G>A	ENST00000245957.5	+	23	3143	c.3067G>A	c.(3067-3069)Gag>Aag	p.E1023K	C20orf26_ENST00000377309.2_Intron	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	1023										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		GCCTGTGACCGAGCCACCAGC	0.483000													15	44					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56137941	56137941	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:56137941C>T	ENST00000319441.4	+	4	760	c.596C>T	c.(595-597)cCt>cTt	p.P199L	PCK1_ENST00000535860.1_Missense_Mutation_p.P67L|PCK1_ENST00000543666.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	199					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GTGGGGTGCCCTCTGCCTTTA	0.527000													5	50					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86394637	86394637	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:86394637G>A	ENST00000361669.2	+	2	1275	c.176G>A	c.(175-177)cGa>cAa	p.R59Q	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Intron|GRM3_ENST00000394720.2_Missense_Mutation_p.R57Q|GRM3_ENST00000439827.1_Missense_Mutation_p.R59Q	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	59					synaptic transmission	integral to plasma membrane		p.R59Q(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GAATGTGGGCGAATCAATGAA	0.418000													29	117					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39969292	39969292	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:39969292C>T	ENST00000321562.4	+	1	110	c.6C>T	c.(4-6)ttC>ttT	p.F2F		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	2					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GCACCATGTTCCCCGCGGGCC	0.731000													8	14					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113405329	113405329	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:113405329G>A	ENST00000228928.7	+	13	2975	c.2796G>A	c.(2794-2796)cgG>cgA	p.R932R	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	932	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						AGCTACAACGGGACTTCATCA	0.572000													8	21					0	0	1	0	0
PTK7	5754	broad.mit.edu	37	6	43109528	43109528	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:43109528C>T	ENST00000230419.4	+	11	1962	c.1741C>T	c.(1741-1743)Cgt>Tgt	p.R581C	PTK7_ENST00000481273.1_Missense_Mutation_p.R589C|PTK7_ENST00000345201.2_Missense_Mutation_p.R541C|PTK7_ENST00000349241.2_Missense_Mutation_p.R451C|PTK7_ENST00000352931.2_Missense_Mutation_p.R581C	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	581	Ig-like C2-type 6.|Ig-like C2-type 7.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GGGCCAGATTCGTGCCCATGT	0.657000													38	111					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509611	71509611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:71509611G>A	ENST00000396073.3	+	9	2749	c.2468G>A	c.(2467-2469)tGg>tAg	p.W823*	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	823					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AATCCAATATGGCATGAAGGT	0.438000													20	64					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76464764	76464764	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:76464764C>T	ENST00000389840.5	-	55	8795	c.8671G>A	c.(8671-8673)Ggc>Agc	p.G2891S	DNAH17_ENST00000585328.1_Missense_Mutation_p.G2900S|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCATTCATGCCAAGGGACTTG	0.552000													13	38					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205273193	205273193	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:205273193C>T	ENST00000367157.3	-	7	1398	c.1272G>A	c.(1270-1272)gaG>gaA	p.E424E		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	424					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CCGGAGGGTCCTCCTGTACCC	0.627000													47	66					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981225	7981225	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:7981225C>T	ENST00000328600.2	-	2	2095	c.1934G>A	c.(1933-1935)gGg>gAg	p.G645E		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	645							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTCCTCTGTCCCTCTGCCTTT	0.383000													13	41					0	0	1	0	0
KCNAB1	7881	broad.mit.edu	37	3	155861118	155861118	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155861118G>A	ENST00000471742.1	+	1	368	c.151G>A	c.(151-153)Gca>Aca	p.A51T	KCNAB1_ENST00000490337.1_Intron|KCNAB1_ENST00000389636.5_Intron	NM_003471.3	NP_003462.2	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	0						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			GCCCAGTGGAGCAGCCGAACA	0.512000													27	64					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179600700	179600700	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179600700C>T	ENST00000589042.1	-	50	14697	c.14473G>A	c.(14473-14475)Gaa>Aaa	p.E4825K	TTN_ENST00000342992.6_Missense_Mutation_p.E3581K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E4508K|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4508	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAATGGTTTCTATCACAGGA	0.463000													31	65					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137749945	137749945	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:137749945G>A	ENST00000183605.5	+	5	974	c.748G>A	c.(748-750)Gag>Aag	p.E250K	CLDN18_ENST00000343735.4_Missense_Mutation_p.E250K	NM_016369.3	NP_057453.1	P56856	CLD18_HUMAN	claudin 18	250					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						CACAGAGGACGAGGTACAATC	0.517000													43	112					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2071147	2071147	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:2071147C>T	ENST00000262113.4	+	29	3617	c.3476C>T	c.(3475-3477)aCc>aTc	p.T1159I	MYOM2_ENST00000523438.1_Missense_Mutation_p.T584I	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1159	Ig-like C2-type 4.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAGAAAGAAACCGTTTTCAAA	0.408000													8	79					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25304717	25304717	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25304717C>T	ENST00000549804.2	+	0	110				SNHG14_ENST00000384733.1_RNA																							AAAAAACATTCCTTGGAAAAG	0.502000													71	206					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21228515	21228515	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:21228515G>A	ENST00000233242.1	-	26	11352	c.11225C>T	c.(11224-11226)tCa>tTa	p.S3742L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3742					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACAAGAACTGAATTTAGATC	0.383000													49	157					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045526	142045526	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:142045526C>T	ENST00000390392.3	+	0	165																											CCGCAGTCCCCATGGAAACGG	0.478000													45	150					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145806329	145806329	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:145806329G>A	ENST00000276826.5	-	2	614	c.413C>T	c.(412-414)tCc>tTc	p.S138F	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.S138F|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.S138F			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	138					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						CTCCAGGGAGGAGCTGGTGCT	0.716000													4	18					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139717522	139717522	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:139717522C>T	ENST00000263552.6	+	16	1957	c.1419C>T	c.(1417-1419)ttC>ttT	p.F473F	TBXAS1_ENST00000425687.1_Silent_p.F405F|TBXAS1_ENST00000416849.2_Silent_p.F519F|TBXAS1_ENST00000411653.1_Intron|TBXAS1_ENST00000414508.2_Intron|TBXAS1_ENST00000458722.1_Silent_p.F518F|TBXAS1_ENST00000336425.5_Silent_p.F472F|TBXAS1_ENST00000436047.2_Silent_p.F473F|TBXAS1_ENST00000448866.1_Silent_p.F472F	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	472					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					ACCTGCCCTTCGGGGCCGGCC	0.682000													15	73					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179603955	179603955	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:179603955C>T	ENST00000589042.1	-	48	14229	c.14005G>A	c.(14005-14007)Gaa>Aaa	p.E4669K	TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E4306K|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E4498K|TTN_ENST00000359218.5_Missense_Mutation_p.E4431K|TTN_ENST00000591111.1_Missense_Mutation_p.E4352K|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4352	Ig-like 27.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATGGTCTTCGGTATTTACT	0.378000													10	28					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	11004048	11004048	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:11004048G>A	ENST00000324288.8	+	13	2953	c.2820G>A	c.(2818-2820)acG>acA	p.T940T	CIITA_ENST00000381835.5_Silent_p.T356T|CIITA_ENST00000537380.1_3'UTR	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	940			Missing (in BLS2).		interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						TCTCCAGGACGAGAAGTTCCT	0.567000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								5	20					0	0	1	0	0
TNFSF15	9966	broad.mit.edu	37	9	117554722	117554722	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117554722C>T	ENST00000374045.4	-	3	379	c.266G>A	c.(265-267)aGa>aAa	p.R89K		NM_001204344.1|NM_005118.3	NP_001191273.1|NP_005109.2	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily, member 15	89					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11						TCCGTCTGCTCTAAGAGGTGC	0.488000													14	50					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206869967	206869967	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:206869967G>A	ENST00000403263.1	-	11	2613	c.2209C>T	c.(2209-2211)Cgt>Tgt	p.R737C		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	737					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						GTAGCAGAACGGAGCAGGTTC	0.522000													15	48					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303883	151303883	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:151303883G>A	ENST00000370323.4	-	4	526	c.210C>T	c.(208-210)acC>acT	p.T70T	MAGEA10_ENST00000244096.3_Silent_p.T70T|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	70										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCTCTGGGGTGCTTGGTA	0.532000													54	40					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35025869	35025869	+	Splice_Site	SNP	T	T	C			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:35025869T>C	ENST00000231420.6	-	9	1162	c.963_splice	c.e9+1	p.E321_splice		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	321					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding	p.E321G(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GCCACTTACTTCATCTGCAAT	0.512000													15	45					0	0	1	0	0
CALHM1	255022	broad.mit.edu	37	10	105218356	105218356	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:105218356G>A	ENST00000329905.5	-	1	289	c.153C>T	c.(151-153)gcC>gcT	p.A51A	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	51						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						CCGCGCTGTAGGCTGCATTGT	0.612000													22	74					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81643776	81643776	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:81643776G>A	ENST00000356860.3	-	13	1501	c.1163C>T	c.(1162-1164)tCa>tTa	p.S388L	MIR1255B1_ENST00000454066.1_RNA|MIR1255B1_ENST00000439234.1_RNA|CACNA2D1_ENST00000464354.1_5'UTR|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.S388L	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	388	VWFA.					voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTGACCAACTGAAAACGTGAA	0.308000													13	46					0	0	1	0	0
HINT1	3094	broad.mit.edu	37	5	130498346	130498346	+	Missense_Mutation	SNP	G	G	A	rs1802917		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:130498346G>A	ENST00000513012.1	-	2	220	c.170C>T	c.(169-171)cCc>cTc	p.P57L	HINT1_ENST00000508488.1_Silent_p.S45S|HINT1_ENST00000506207.1_5'UTR|HINT1_ENST00000506908.1_Silent_p.S45S|HINT1_ENST00000304043.5_Silent_p.S45S			P49773	HINT1_HUMAN	histidine triad nucleotide binding protein 1	0	HIT.				signal transduction	cytoplasm|cytoskeleton|nucleus	hydrolase activity|protein kinase C binding			endometrium(1)|large_intestine(1)|lung(3)	5		all_cancers(142;0.0452)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Adenosine monophosphate(DB00131)	GTGCTTGAGGGGAAATGTCAT	0.328000													17	81					0	0	1	0	0
TEX11	56159	broad.mit.edu	37	X	70080744	70080744	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:70080744G>A	ENST00000395889.2	-	6	487	c.332C>T	c.(331-333)tCa>tTa	p.S111L	TEX11_ENST00000374333.2_Missense_Mutation_p.S96L|TEX11_ENST00000344304.3_Missense_Mutation_p.S111L	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11	111							protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					TGAGGCAAATGAGGCTTCACA	0.338000													21	13					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55110892	55110892	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:55110892C>T	ENST00000314721.2	+	1	266	c.216C>T	c.(214-216)tcC>tcT	p.S72S		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	72					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						CCATATATTCCACTGCCATGT	0.443000													67	189					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71125403	71125403	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:71125403G>A	ENST00000299213.8	-	3	534	c.464C>T	c.(463-465)tCa>tTa	p.S155L		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	155	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						AAGGACCACTGAATACTTCAA	0.502000													24	80					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164393478	164393478	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:164393478C>T	ENST00000280605.3	-	1	1569	c.1409G>A	c.(1408-1410)gGa>gAa	p.G470E		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	470						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAAGCACATTCCCTTGGTATT	0.468000													45	113					0	0	1	0	0
LPAR5	57121	broad.mit.edu	37	12	6730251	6730251	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6730251G>A	ENST00000329858.4	-	2	920	c.164C>T	c.(163-165)tCg>tTg	p.S55L	LPAR5_ENST00000431922.1_Missense_Mutation_p.S55L|LPAR5_ENST00000540335.1_5'UTR	NM_020400.5	NP_065133.1	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	55						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7						GCTCACCACCGAGTGCACGCG	0.662000													5	28					0	0	1	0	0
MEF2B	100271849	broad.mit.edu	37	19	19257422	19257422	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:19257422G>A	ENST00000409447.2	-	7	808	c.577C>T	c.(577-579)Cac>Tac	p.H193Y	MEF2BNB-MEF2B_ENST00000444486.3_Silent_p.S237S|MEF2B_ENST00000162023.5_Silent_p.S237S|MEF2B_ENST00000410050.1_Silent_p.S237S|MEF2B_ENST00000409224.1_Silent_p.S240S|MEF2B_ENST00000602424.2_Silent_p.S237S|MEF2BNB-MEF2B_ENST00000514819.3_Silent_p.S254S|MEF2B_ENST00000424583.2_Silent_p.S237S					myocyte enhancer factor 2B											breast(1)|haematopoietic_and_lymphoid_tissue(21)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			GAGTTGCAGTGGAGCAGGGGT	0.672000													7	18					0	0	1	0	0
INO80E	283899	broad.mit.edu	37	16	30012298	30012298	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:30012298C>T	ENST00000563197.1	+	5	1350	c.333C>T	c.(331-333)tcC>tcT	p.S111S	INO80E_ENST00000567254.1_Silent_p.S111S|INO80E_ENST00000304516.7_Silent_p.S111S|INO80E_ENST00000567705.1_Silent_p.S111S	NM_173618.1	NP_775889.1	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	111	Pro-rich.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	6						CCAGCCTCTCCCTGCCTCCTT	0.657000													17	62					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983855	97983855	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97983855G>A	ENST00000383696.2	+	1	768	c.727G>A	c.(727-729)Gaa>Aaa	p.E243K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TACAATCTTAGAAAAGAAGTC	0.343000													20	41					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38655274	38655274	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:38655274G>A	ENST00000443581.1	-	6	856	c.663C>T	c.(661-663)ttC>ttT	p.F221F	SCN5A_ENST00000423572.2_Silent_p.F221F|SCN5A_ENST00000425664.1_Intron|SCN5A_ENST00000455624.2_Intron|SCN5A_ENST00000450102.2_Intron|SCN5A_ENST00000449557.2_Silent_p.F221F|SCN5A_ENST00000413689.1_Intron|SCN5A_ENST00000414099.2_Intron|SCN5A_ENST00000451551.2_Intron|SCN5A_ENST00000333535.4_Silent_p.F221F	NM_000335.4|NM_198056.2	NP_000326.2|NP_932173.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	221					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGAGGACTCGGAAGGTGCGTA	0.483000													7	18					0	0	1	0	0
VASH1	22846	broad.mit.edu	37	14	77229182	77229182	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:77229182G>A	ENST00000167106.4	+	1	651	c.18G>A	c.(16-18)aaG>aaA	p.K6K	VASH1_ENST00000554237.1_Silent_p.K6K	NM_014909.4	NP_055724.1	Q7L8A9	VASH1_HUMAN	vasohibin 1	6					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space				breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|urinary_tract(3)	10			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		GGGGGAAGAAGGTGGCTGGGG	0.652000													6	4					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9009648	9009648	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9009648C>T	ENST00000397910.4	-	39	39281	c.39078G>A	c.(39076-39078)gaG>gaA	p.E13026E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13028	SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACGCATGTCCTCCCCATACT	0.542000													57	124					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101598755	101598755	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:101598755C>T	ENST00000335681.5	+	16	1830	c.1545C>T	c.(1543-1545)atC>atT	p.I515I	NPAS2_ENST00000542504.1_Silent_p.I580I	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	515					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GGACGCGGATCCTGCAGGCCA	0.547000													4	53					0	0	1	0	0
KHDC3L	154288	broad.mit.edu	37	6	74073372	74073372	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:74073372C>T	ENST00000370367.3	+	3	496	c.443C>T	c.(442-444)tCg>tTg	p.S148L		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		ACGCAGCGTTCGGTGGAGGTC	0.677000													28	31					0	0	1	0	0
LIMK2	3985	broad.mit.edu	37	22	31608409	31608409	+	Splice_Site	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:31608409G>A	ENST00000331728.4	+	1	129	c.16_splice	c.e1+1	p.A5_splice	LIMK2_ENST00000444929.2_Splice_Site_p.A5_splice|LIMK2_ENST00000406516.1_5'UTR	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	5						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						CCGCGCTGGCGGGTAAGGAAG	0.672000													14	22					0	0	1	0	0
TMCO5A	145942	broad.mit.edu	37	15	38230404	38230404	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:38230404C>T	ENST00000558158.1	+	6	515	c.361C>T	c.(361-363)Cca>Tca	p.P121S	TMCO5A_ENST00000540944.1_Missense_Mutation_p.P121S|TMCO5A_ENST00000319669.4_Missense_Mutation_p.P121S|TMCO5A_ENST00000559502.1_Missense_Mutation_p.P121S			Q8N6Q1	TMC5A_HUMAN	transmembrane and coiled-coil domains 5A	121						integral to membrane				central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	15						ACAAAGCAGTCCAGATGGAGC	0.333000													6	9					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883024	228883024	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:228883024C>T	ENST00000392056.3	-	7	2592	c.2546G>A	c.(2545-2547)aGt>aAt	p.S849N	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S849N	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	849						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCATTCTCACTGTGATGAGG	0.498000													42	88					0	0	1	0	0
USP5	8078	broad.mit.edu	37	12	6966849	6966849	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:6966849C>T	ENST00000229268.8	+	7	878	c.826C>T	c.(826-828)Ctg>Ttg	p.L276L	USP5_ENST00000389231.5_Silent_p.L276L	NM_001098536.1	NP_001092006.1	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 (isopeptidase T)	276					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(6)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|skin(2)|urinary_tract(2)	36						GGCTGAGCACCTGTCCCACTT	0.547000													43	98					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123457790	123457790	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:123457790G>A	ENST00000360772.3	-	8	920	c.542C>T	c.(541-543)tCc>tTc	p.S181F	MYLK_ENST00000346322.5_Missense_Mutation_p.S181F|MYLK_ENST00000359169.1_Missense_Mutation_p.S181F|MYLK_ENST00000475616.1_Missense_Mutation_p.S181F|MYLK_ENST00000360304.3_Missense_Mutation_p.S181F			Q15746	MYLK_HUMAN	myosin light chain kinase	181	Ig-like C2-type 2.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GATCTTGCAGGAGAATCGTCC	0.572000													7	27					0	0	1	0	0
FOXS1	2307	broad.mit.edu	37	20	30432457	30432457	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:30432457C>T	ENST00000375978.3	-	1	963	c.889G>A	c.(889-891)Gaa>Aaa	p.E297K		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	297					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						ACCCAGGGTTCCTTGTGGTCA	0.652000													13	31					0	0	1	0	0
MBNL2	10150	broad.mit.edu	37	13	98018783	98018783	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:98018783C>T	ENST00000345429.6	+	8	1846	c.1065C>T	c.(1063-1065)ttC>ttT	p.F355F	MBNL2_ENST00000376673.3_Intron|MBNL2_ENST00000397601.1_Intron|MBNL2_ENST00000343600.4_Intron|MBNL2_ENST00000445661.2_Intron	NM_144778.3	NP_659002.1	Q5VZF2	MBNL2_HUMAN	muscleblind-like splicing regulator 2	165					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			GTGTCCCCTTCGCAGCAACAG	0.463000													29	123					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540465	133540465	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:133540465C>T	ENST00000409261.1	-	14	4292	c.3919G>A	c.(3919-3921)Gag>Aag	p.E1307K	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.E1307K	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1307							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTGCCTCTCTCGGCGGTATTG	0.567000													26	63					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37353567	37353567	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:37353567G>A	ENST00000217420.1	+	1	463	c.200G>A	c.(199-201)gGa>gAa	p.G67E		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	67					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	AAAGCCGAGGGAGAGCCCTGC	0.677000													5	42					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053935	133053935	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:133053935G>A	ENST00000262283.5	-	8	868	c.769C>T	c.(769-771)Ccc>Tcc	p.P257S	OC90_ENST00000443356.2_Missense_Mutation_p.P61S|OC90_ENST00000254627.3_Missense_Mutation_p.P61S|OC90_ENST00000603859.1_Missense_Mutation_p.P61S			Q02509	OC90_HUMAN	otoconin 90	61					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GTGAAGTGGGGGCCCAGGCAA	0.587000													10	16					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89531723	89531723	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:89531723C>T	ENST00000329758.1	-	8	1262	c.934G>A	c.(934-936)Gga>Aga	p.G312R	TRIM49_ENST00000532501.2_Missense_Mutation_p.G235R	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	312	B30.2/SPRY.					intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TGGTCACATCCAATACACATG	0.373000													18	59					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66209075	66209075	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:66209075C>T	ENST00000360689.5	+	11	3402	c.1675C>T	c.(1675-1677)Cga>Tga	p.R559*	FUT8_ENST00000394585.1_Nonsense_Mutation_p.R559*|FUT8_ENST00000557164.1_Nonsense_Mutation_p.R396*|FUT8_ENST00000417683.1_Nonsense_Mutation_p.R153*|FUT8_ENST00000358307.2_Nonsense_Mutation_p.R430*|FUT8_ENST00000394586.2_Nonsense_Mutation_p.R559*	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	559	SH3.				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		CTACAAAGTTCGAGAGAAGAT	0.448000													21	59					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237791148	237791148	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237791148G>A	ENST00000366574.2	+	41	6525	c.6208G>A	c.(6208-6210)Gct>Act	p.A2070T	RYR2_ENST00000360064.6_Missense_Mutation_p.A2068T|RYR2_ENST00000542537.1_Missense_Mutation_p.A2054T	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2070	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTCCGATGGGCTCAGGAGTC	0.493000													6	27					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3102809	3102809	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:3102809C>T	ENST00000378398.3	+	2	240	c.158C>T	c.(157-159)cCc>cTc	p.P53L	PRDM16_ENST00000378391.2_Missense_Mutation_p.P53L|PRDM16_ENST00000442529.2_Missense_Mutation_p.P53L|PRDM16_ENST00000441472.2_Missense_Mutation_p.P53L|PRDM16_ENST00000514189.1_Missense_Mutation_p.P53L|PRDM16_ENST00000270722.5_Missense_Mutation_p.P53L|PRDM16_ENST00000511072.1_Missense_Mutation_p.P53L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	53					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCACCGTCCCCCTTCCCCACC	0.647000			T	EVI1	"""MDS, AML"""								13	102					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113638980	113638980	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:113638980C>T	ENST00000361127.4	+	8	1282	c.1084C>T	c.(1084-1086)Cag>Tag	p.Q362*		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	362						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TTCCAATCTTCAGACATTGTA	0.323000													37	100					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217124264	217124264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:217124264C>T	ENST00000273067.4	-	4	2770	c.1004G>A	c.(1003-1005)cGg>cAg	p.R335Q		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	335						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		TGAGGAGGTCCGGGGGTTGGT	0.617000													10	30					0	0	1	0	0
AC005754.7	0	broad.mit.edu	37	5	140480201	140480201	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140480201G>A	ENST00000607216.1	-	0	208																											TCAGCTTGGCGACATTCCCTG	0.512000													21	45					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47260154	47260154	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr13:47260154C>T	ENST00000311191.6	+	5	1029	c.800C>T	c.(799-801)cCt>cTt	p.P267L	LRCH1_ENST00000389797.3_Missense_Mutation_p.P267L|LRCH1_ENST00000389798.3_Missense_Mutation_p.P267L	NM_001164213.1	NP_001157685.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	267										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GAGAATAACCCTCTGCAGTCT	0.473000													18	55					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23197734	23197734	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23197734C>T	ENST00000300061.2	+	2	285	c.142C>T	c.(142-144)Cgc>Tgc	p.R48C		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	48					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	CGTGGTGTCCCGCGGCCGTCT	0.637000													10	46					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100386959	100386959	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:100386959G>A	ENST00000542585.1	+	0	7492				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TTGGTGGAAGGAAAAATGCAG	0.537000													35	65					0	0	1	0	0
SLC2A14	144195	broad.mit.edu	37	12	7966949	7966949	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:7966949C>T	ENST00000543909.1	-	16	2285	c.1526G>A	c.(1525-1527)aGc>aAc	p.S509N	SLC2A14_ENST00000542505.1_Missense_Mutation_p.S150N|SLC2A14_ENST00000396589.2_Missense_Mutation_p.S509N|SLC2A14_ENST00000340749.5_Missense_Mutation_p.S486N|SLC2A14_ENST00000535295.1_Missense_Mutation_p.S400N|SLC2A14_ENST00000431042.2_Missense_Mutation_p.S486N|SLC2A14_ENST00000539924.1_Missense_Mutation_p.S524N|SLC2A14_ENST00000542546.1_Missense_Mutation_p.S400N			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	509					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		AGGCTCGATGCTGTTCATCCC	0.577000													31	276					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9056563	9056563	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:9056563G>A	ENST00000397910.4	-	3	31086	c.30883C>T	c.(30883-30885)Cca>Tca	p.P10295S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10297	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGGCTCGTGGAACTCCAGTG	0.522000													21	79					0	0	1	0	0
EXT1	2131	broad.mit.edu	37	8	118819608	118819608	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:118819608G>A	ENST00000378204.2	-	9	2537	c.1731C>T	c.(1729-1731)ttC>ttT	p.F577F		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	577					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			CTGTGAAGGCGAAATCCACCT	0.483000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				15	48					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116064542	116064542	+	Missense_Mutation	SNP	G	G	A	rs148589522		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:116064542G>A	ENST00000369271.3	-	11	1520	c.1220C>T	c.(1219-1221)cCc>cTc	p.P407L	AFAP1L2_ENST00000545353.1_Missense_Mutation_p.P460L|AFAP1L2_ENST00000304129.4_Missense_Mutation_p.P407L	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	407	PH 2.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GTCGGGGCTGGGGTCTGGGAC	0.667000													7	62					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189830	124189830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:124189830C>T	ENST00000357438.2	-	1	354	c.264G>A	c.(262-264)gaG>gaA	p.E88E		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TAATGTTCTCCTCTGGAACAA	0.388000													21	49					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91739116	91739116	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:91739116C>T	ENST00000389857.6	-	30	6026	c.5940G>A	c.(5938-5940)aaG>aaA	p.K1980K	CCDC88C_ENST00000331194.7_Silent_p.K504K	NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1980					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				GACCTGGGCTCTTGGCCGGAA	0.711000													14	23					0	0	1	0	0
PBXIP1	57326	broad.mit.edu	37	1	154917523	154917523	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154917523G>A	ENST00000368463.3	-	11	2244	c.2173C>T	c.(2173-2175)Cac>Tac	p.H725Y	PBXIP1_ENST00000542459.1_Missense_Mutation_p.H570Y|PBXIP1_ENST00000368465.1_Missense_Mutation_p.H696Y|PBXIP1_ENST00000539880.1_Missense_Mutation_p.H552Y	NM_020524.2	NP_065385.2	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein 1	725	His-rich.				cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			breast(1)|kidney(2)|large_intestine(6)|lung(13)|prostate(1)|urinary_tract(1)	24	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGGTGGTGGTGGCTATGGCTG	0.642000													20	47					0	0	1	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43678849	43678849	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:43678849C>T	ENST00000374466.3	+	8	1823	c.1488C>T	c.(1486-1488)ccC>ccT	p.P496P		NM_018590.3	NP_061060.3	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 2	496					chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding	p.P496P(1)		endometrium(12)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						AGCTGACCCCCGAGCAGTACC	0.517000													22	212					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39227430	39227430	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:39227430C>T	ENST00000340369.3	-	2	3735	c.3507G>A	c.(3505-3507)agG>agA	p.R1169R	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1169							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGGCAGTCTCCCTGTGCCTTG	0.637000													12	29					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77666836	77666836	+	Missense_Mutation	SNP	T	T	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:77666836T>G	ENST00000461745.1	+	22	4366	c.3466T>G	c.(3466-3468)Tcc>Gcc	p.S1156A	ROBO2_ENST00000487694.3_Missense_Mutation_p.S1172A|ROBO2_ENST00000469233.1_3'UTR|ROBO2_ENST00000332191.8_Missense_Mutation_p.S1156A	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1156					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCTTACTCCATCCCCACGGGA	0.488000													13	90					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	36895318	36895318	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:36895318C>T	ENST00000310758.4	-	22	2669	c.2022G>A	c.(2020-2022)ggG>ggA	p.G674G	ELMO1_ENST00000396040.2_Silent_p.G194G|ELMO1_ENST00000448602.1_Silent_p.G674G|ELMO1_ENST00000442504.1_Silent_p.G674G|ELMO1_ENST00000396045.3_Silent_p.G194G|ELMO1_ENST00000341056.3_Silent_p.G376G	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	674	PH.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TCATGTCCTTCCCGAGTAGCG	0.517000													34	105					0	0	1	0	0
RNF133	168433	broad.mit.edu	37	7	122338165	122338165	+	Missense_Mutation	SNP	G	G	A	rs113296018	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:122338165G>A	ENST00000340112.2	-	1	1045	c.808C>T	c.(808-810)Cgt>Tgt	p.R270C	CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000412584.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	270						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						GTCAGAATACGAACTATGTCA	0.388000													41	104					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16000301	16000301	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:16000301C>T	ENST00000221700.5	-	7	945	c.850G>A	c.(850-852)Gat>Aat	p.D284N	CYP4F2_ENST00000592328.1_Missense_Mutation_p.D284N|CYP4F2_ENST00000011989.7_Missense_Mutation_p.D135N	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	284					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AGGAAGTCATCAACACCCTGG	0.577000													35	127					0	0	1	0	0
SH3PXD2B	285590	broad.mit.edu	37	5	171765398	171765398	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:171765398G>A	ENST00000311601.5	-	13	2881	c.2711C>T	c.(2710-2712)tCc>tTc	p.S904F	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	904	SH3 4.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAGATAGTTGGAAGGAATCCA	0.547000													30	95					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604792	58604792	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:58604792C>T	ENST00000267485.7	-	2	1479	c.1285G>A	c.(1285-1287)Gat>Aat	p.D429N	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	429						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						AACAGGGCATCGTTTTCCTTG	0.413000													16	84					0	0	1	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113661535	113661535	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:113661535C>T	ENST00000393544.2	+	0	1583																											CTTCCCCTTTCCCCAGGGGTC	0.542000													10	118					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228525785	228525785	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:228525785C>T	ENST00000570156.2	+	78	19886	c.19812C>T	c.(19810-19812)acC>acT	p.T6604T	OBSCN_ENST00000366707.4_Silent_p.T3281T|OBSCN_ENST00000422127.1_Silent_p.T5647T|OBSCN_ENST00000284548.11_Silent_p.T5647T|OBSCN_ENST00000366709.4_Silent_p.T2766T	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5647	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCAAGCCCACCAAGTCCAGCC	0.652000													6	15					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136587237	136587237	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:136587237C>T	ENST00000264162.2	-	3	740	c.730G>A	c.(730-732)Gat>Aat	p.D244N		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	244	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGAGGAAATCGACCGTGTCC	0.408000													33	78					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14880842	14880842	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:14880842G>A	ENST00000403951.2	-	2	466	c.47C>T	c.(46-48)tCc>tTc	p.S16F	DGKB_ENST00000402815.1_Missense_Mutation_p.S16F|DGKB_ENST00000258767.5_Missense_Mutation_p.S16F|DGKB_ENST00000444700.2_Missense_Mutation_p.S16F|DGKB_ENST00000399322.3_Missense_Mutation_p.S16F|DGKB_ENST00000407950.1_Missense_Mutation_p.S16F|DGKB_ENST00000406247.3_Missense_Mutation_p.S16F|DGKB_ENST00000403963.1_5'UTR			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	16					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CTGAAGTTGGGAAAATTCCGA	0.368000													6	15					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115607039	115607039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:115607039G>A	ENST00000361384.2	-	3	3098	c.2181C>T	c.(2179-2181)gcC>gcT	p.A727A	DCLRE1A_ENST00000369305.1_Silent_p.A727A	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	727					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		TGAGAAAATAGGCTGTGCAAC	0.383000								Other identified genes with known or suspected DNA repair function					17	42					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41797462	41797462	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:41797462C>T	ENST00000263800.6	-	15	1965	c.1869G>A	c.(1867-1869)ctG>ctA	p.L623L	LTK_ENST00000355166.5_Silent_p.L562L|LTK_ENST00000453182.2_Silent_p.L493L|LTK_ENST00000561619.1_Silent_p.L321L	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	623	Protein kinase.				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TGTCCTGGGCCAGTTGCAGCA	0.602000										TSP Lung(18;0.14)			18	39					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100235830	100235830	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:100235830C>T	ENST00000355295.4	+	11	2296	c.2001C>T	c.(1999-2001)ctC>ctT	p.L667L	TDRD7_ENST00000422139.2_Silent_p.L593L|TDRD7_ENST00000540902.1_Silent_p.L16L	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	667					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				ATGGGACACTCTACTGCCAGG	0.438000													13	183					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673345	186673345	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:186673345G>A	ENST00000343098.5	+	17	19579	c.19579G>A	c.(19579-19581)Gaa>Aaa	p.E6527K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E6438K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2									p.E1136K(2)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						AACCAACAAAGAATTTTATTA	0.303000													6	30					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32750561	32750561	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:32750561C>T	ENST00000421745.2	+	59	11920	c.11786C>T	c.(11785-11787)tCa>tTa	p.S3929L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	3929					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CGTGCTGTGTCAGCTACACCA	0.428000													28	57					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152536101	152536101	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:152536101C>T	ENST00000367255.5	-	122	22887	c.22286G>A	c.(22285-22287)aGa>aAa	p.R7429K	SYNE1_ENST00000341594.5_Missense_Mutation_p.R7041K|SYNE1_ENST00000423061.1_Missense_Mutation_p.R7358K|SYNE1_ENST00000356820.4_Missense_Mutation_p.R1953K|SYNE1_ENST00000448038.1_Missense_Mutation_p.R7358K|SYNE1_ENST00000265368.4_Missense_Mutation_p.R7429K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7429					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTCTGCATTCTTTTGATTTC	0.413000										HNSCC(10;0.0054)			66	80					0	0	1	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47117396	47117396	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:47117396C>T	ENST00000290341.3	+	7	1095	c.761C>T	c.(760-762)tCc>tTc	p.S254F	IGF2BP1_ENST00000431824.2_Intron	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	254	KH 1.|Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GAGGGCTGCTCCTCCGCTTGT	0.517000													56	67					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903153	5903153	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:5903153G>A	ENST00000378961.4	+	4	567	c.363G>A	c.(361-363)gaG>gaA	p.E121E		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	121						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						CAGACACAGAGAAATGGGCAG	0.627000													21	22					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105407933	105407933	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:105407933C>T	ENST00000333244.5	-	7	13974	c.13855G>A	c.(13855-13857)Gag>Aag	p.E4619K	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4619						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCTACATCCTCGTGGGCCAGG	0.547000													40	98					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369418	22369418	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:22369418C>T	ENST00000332663.2	+	1	941	c.843C>T	c.(841-843)ttC>ttT	p.F281F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTTTAATATTCCCTTTACGTA	0.378000													6	77					0	0	1	0	0
GSTM1	2944	broad.mit.edu	37	1	110230845	110230845	+	Missense_Mutation	SNP	A	A	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:110230845A>T	ENST00000309851.5	+	2	144	c.90A>T	c.(88-90)gaA>gaT	p.E30D	GSTM1_ENST00000483399.2_Missense_Mutation_p.E30D|GSTM2_ENST00000460717.3_Intron|GSTM1_ENST00000369819.2_Missense_Mutation_p.E30D|GSTM1_ENST00000369823.2_Missense_Mutation_p.E30D|GSTM2_ENST00000369831.2_Intron|GSTM1_ENST00000349334.3_Missense_Mutation_p.E30D|GSTM1_ENST00000490021.2_Intron	NM_000561.3	NP_000552.2	P09488	GSTM1_HUMAN	glutathione S-transferase mu 1	30	GST N-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity			endometrium(1)|lung(1)|ovary(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	GCTATGAGGAAAAGAAGTACA	0.607000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				72	56					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155222375	155222375	+	Missense_Mutation	SNP	C	C	T	rs149590749	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:155222375C>T	ENST00000460012.1	-	13	1940	c.1583G>A	c.(1582-1584)cGa>cAa	p.R528Q	PLCH1_ENST00000334686.6_Missense_Mutation_p.R528Q|PLCH1_ENST00000494598.1_Missense_Mutation_p.R546Q|PLCH1_ENST00000447496.2_Missense_Mutation_p.R546Q|PLCH1_ENST00000340059.7_Missense_Mutation_p.R546Q|PLCH1_ENST00000414191.1_Missense_Mutation_p.R528Q			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	546					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CATGAGGGATCGTCCATGTGA	0.313000													23	68					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38743715	38743715	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr6:38743715C>T	ENST00000359357.3	+	11	1553	c.1299C>T	c.(1297-1299)atC>atT	p.I433I	DNAH8_ENST00000449981.2_Silent_p.I650I|DNAH8_ENST00000441566.1_Silent_p.I433I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGACAAAAATCAATGGTTTAG	0.308000													46	117					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41045878	41045878	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:41045878C>T	ENST00000399564.4	-	18	2256	c.1806G>A	c.(1804-1806)atG>atA	p.M602I	MROH2B_ENST00000506092.2_Missense_Mutation_p.M157I	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TGTAACTGCCCATTTGCTGTT	0.443000													56	167					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20819666	20819666	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:20819666G>A	ENST00000328879.4	-	4	747	c.591C>T	c.(589-591)taC>taT	p.Y197Y	KLHL22_ENST00000440659.2_Silent_p.Y54Y	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	197					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TGAGGAGGGAGTAGACCTTCT	0.557000													25	44					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13322932	13322932	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:13322932G>A	ENST00000360228.5	-	43	6287	c.6288C>T	c.(6286-6288)ctC>ctT	p.L2096L	CACNA1A_ENST00000573710.2_Silent_p.L2097L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	2097					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCTCTGCAGGGAGGCGGGGCA	0.667000													9	39					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140431416	140431416	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140431416G>A	ENST00000306549.3	+	1	438	c.361G>A	c.(361-363)Gtc>Atc	p.V121I		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		121	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGCCGAGGTCAGGGTATT	0.517000													18	57					0	0	1	0	0
OR3A4P	390756	broad.mit.edu	37	17	3213625	3213625	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:3213625G>A	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							GGAACTCAGGGAATGATTCAG	0.517000													26	41					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65263330	65263330	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:65263330C>T	ENST00000389722.3	-	10	1339	c.1286G>A	c.(1285-1287)cGg>cAg	p.R429Q	SPTB_ENST00000389720.3_Missense_Mutation_p.R429Q|SPTB_ENST00000389721.5_Missense_Mutation_p.R429Q|SPTB_ENST00000556626.1_Missense_Mutation_p.R429Q|SPTB_ENST00000542895.1_Missense_Mutation_p.R429Q	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	429					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGCGGCCTTCCGGTCAAAGCG	0.587000													21	56					0	0	1	0	0
PTPDC1	138639	broad.mit.edu	37	9	96827036	96827036	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:96827036C>T	ENST00000375360.3	+	2	355	c.15C>T	c.(13-15)gtC>gtT	p.V5V		NM_001253830.1|NM_177995.2	NP_001240759.1|NP_818931.1	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	5							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	32						CTGCAGGAGTCTTGCCTCAGA	0.368000													20	47					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17444715	17444715	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr22:17444715G>A	ENST00000400588.1	-	9	1588	c.1481C>T	c.(1480-1482)cCg>cTg	p.P494L		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	494										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TGCAGATGCCGGGTTCTGCTG	0.592000													15	44					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71163629	71163629	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:71163629G>A	ENST00000393567.2	-	9	1291	c.1141C>T	c.(1141-1143)Ctg>Ttg	p.L381L	HYDIN_ENST00000538248.1_Silent_p.L408L|HYDIN_ENST00000321489.5_Silent_p.L381L|HYDIN_ENST00000288168.10_Silent_p.L398L|HYDIN_ENST00000448691.1_Silent_p.L381L|HYDIN_ENST00000541601.1_Silent_p.L398L|HYDIN_ENST00000448089.2_Silent_p.L381L|HYDIN_ENST00000393550.2_Silent_p.L381L	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	381										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GTTCGGGACAGAACAGAAAGA	0.458000													13	26					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983578	97983578	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:97983578C>T	ENST00000383696.2	+	1	491	c.450C>T	c.(448-450)gtC>gtT	p.V150V	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TTTATCCAGTCATTATGACCA	0.363000													93	61					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134125730	134125730	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:134125730C>T	ENST00000220616.4	+	44	7677	c.7637C>T	c.(7636-7638)tCt>tTt	p.S2546F	TG_ENST00000377869.1_Missense_Mutation_p.S2489F|TG_ENST00000519543.1_Missense_Mutation_p.S679F|TG_ENST00000542445.1_Missense_Mutation_p.S916F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2546					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTGCAGAATTCTCTGGGTGGC	0.512000													27	70					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23079830	23079830	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:23079830G>A	ENST00000219689.7	-	16	3595	c.3596C>T	c.(3595-3597)tCc>tTc	p.S1199F	USP31_ENST00000567975.1_Missense_Mutation_p.S492F	NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	1199	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GGCCATGGAGGAGCTCCGCAC	0.642000													38	89					0	0	1	0	0
SCLT1	132320	broad.mit.edu	37	4	129873956	129873956	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:129873956G>A	ENST00000281142.5	-	14	1689	c.1186C>T	c.(1186-1188)Cga>Tga	p.R396*	SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000502495.1_5'UTR|SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000503215.1_Intron	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	396						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						TCTGTTAATCGAGAAATTTGT	0.259000													37	104					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102496039	102496039	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:102496039G>A	ENST00000260228.2	-	1	24	c.12C>T	c.(10-12)ctC>ctT	p.L4L	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	4					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CAGATGCAGGGAGCACCTTCA	0.532000													15	44					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6243299	6243299	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6243299G>A	ENST00000400104.3	-	7	654	c.454C>T	c.(454-456)Cct>Tct	p.P152S	L3MBTL4_ENST00000400105.2_Missense_Mutation_p.P152S|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.P152S|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.P152S			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	152					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TTACCCTTAGGGATGTGCAGT	0.368000													25	89					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18391011	18391011	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:18391011C>T	ENST00000338745.6	-	11	3677	c.1943G>A	c.(1942-1944)cGa>cAa	p.R648Q	SATB1_ENST00000454909.2_Missense_Mutation_p.R648Q|SATB1_ENST00000417717.2_Missense_Mutation_p.R680Q|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	648					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						AATTTTTGTTCGTGGCCGGGT	0.587000													35	87					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40368833	40368833	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:40368833C>T	ENST00000221347.6	-	28	12522	c.12515G>A	c.(12514-12516)gGg>gAg	p.G4172E		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4172	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGAAATCCGCCCGTCGGCCAC	0.617000													37	223					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995778	140995778	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrX:140995778C>T	ENST00000285879.4	+	4	2874	c.2588C>T	c.(2587-2589)tCa>tTa	p.S863L	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	863							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCCACTTCATTGAGCCCA	0.517000										HNSCC(15;0.026)			109	66					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12315809	12315809	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:12315809C>T	ENST00000256186.2	+	3	1122	c.831C>T	c.(829-831)atC>atT	p.I277I		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	277					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		CCAATGCCATCCGAAGGTCTC	0.607000													20	56					0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168073894	168073894	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:168073894G>A	ENST00000367838.1	-	4	508	c.195C>T	c.(193-195)ttC>ttT	p.F65F	GPR161_ENST00000367835.1_Silent_p.F65F|GPR161_ENST00000271357.5_Silent_p.F65F|GPR161_ENST00000546300.1_Intron|GPR161_ENST00000367836.1_Intron|GPR161_ENST00000537209.1_Silent_p.F85F|GPR161_ENST00000361697.2_Silent_p.F65F|GPR161_ENST00000539777.1_Intron	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	65					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.F65F(1)		breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					GGCTGAAGACGAACTTGTTGC	0.517000													47	84					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516156	140516156	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140516156G>A	ENST00000231134.5	+	1	1357	c.1140G>A	c.(1138-1140)atG>atA	p.M380I		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		380	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGGTAGGATGATTTGCTCCA	0.488000													32	78					0	0	1	0	0
FYCO1	79443	broad.mit.edu	37	3	45972760	45972760	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:45972760G>A	ENST00000296137.2	-	16	4259	c.4054C>T	c.(4054-4056)Ctc>Ttc	p.L1352F	FYCO1_ENST00000438446.1_Missense_Mutation_p.L23F|FYCO1_ENST00000535325.1_Missense_Mutation_p.L1372F	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	1352	GOLD.				transport	integral to membrane	metal ion binding|protein binding	p.L1352F(1)		NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		TCCACTGTGAGGGGTACTTTG	0.547000													10	32					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57043060	57043060	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr17:57043060G>A	ENST00000308249.2	+	3	718	c.589G>A	c.(589-591)Gag>Aag	p.E197K		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	206					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			CACAGAGATTGAGACAGTGAA	0.463000													112	300					0	0	1	0	0
MIA2	117153	broad.mit.edu	37	14	39721990	39721990	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:39721990G>A	ENST00000280082.3	+	5	1805	c.1606G>A	c.(1606-1608)Gaa>Aaa	p.E536K	RP11-407N17.3_ENST00000553728.1_Intron	NM_054024.3	NP_473365.3	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	145						extracellular region				NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	31	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		GAGAATTCACGAAGAAGTATA	0.378000													27	89					0	0	1	0	0
ZNF597	146434	broad.mit.edu	37	16	3486894	3486894	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:3486894C>T	ENST00000301744.4	-	4	1040	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K	LA16c-306E5.2_ENST00000575785.1_RNA	NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	269					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						TTAGTAGATTCGTAGGTGTTT	0.433000													30	138					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82837305	82837305	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:82837305C>T	ENST00000265077.3	+	8	9048	c.8483C>T	c.(8482-8484)cCc>cTc	p.P2828L	VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.P1841L|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	2828	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCATCATCTCCCCTCACTATC	0.498000													21	127					0	0	1	0	0
L1TD1	54596	broad.mit.edu	37	1	62672641	62672641	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:62672641G>A	ENST00000498273.1	+	3	636	c.341G>A	c.(340-342)gGg>gAg	p.G114E		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	114										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						caaaaaacagggatggtaggg	0.333000													34	116					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947667	237947667	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:237947667G>A	ENST00000366574.2	+	90	12972	c.12655G>A	c.(12655-12657)Gaa>Aaa	p.E4219K	RYR2_ENST00000360064.6_Missense_Mutation_p.E4225K|RYR2_ENST00000542537.1_Missense_Mutation_p.E4203K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4219					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCGAATAAGGAAGAAAGCGA	0.537000													13	55					0	0	1	0	0
PANX1	24145	broad.mit.edu	37	11	93912938	93912938	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:93912938C>T	ENST00000227638.3	+	4	1101	c.716C>T	c.(715-717)tCa>tTa	p.S239L	PANX1_ENST00000436171.2_Missense_Mutation_p.S239L	NM_015368.3	NP_056183.2	Q96RD7	PANX1_HUMAN	pannexin 1	239					positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding			endometrium(2)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGCCTCTCCTCACTCTCAGAC	0.468000													25	83					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60911420	60911420	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr20:60911420G>A	ENST00000252999.3	-	18	2365	c.2299C>T	c.(2299-2301)Ccc>Tcc	p.P767S		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	767	Laminin EGF-like 9.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGTTGCTGGGGCTCAGTCCC	0.622000													23	62					0	0	1	0	0
TPPP2	122664	broad.mit.edu	37	14	21499223	21499223	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:21499223G>A	ENST00000321760.6	+	3	374	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	TPPP2_ENST00000530140.2_Missense_Mutation_p.E76K|TPPP2_ENST00000460647.2_Missense_Mutation_p.E76K|NDRG2_ENST00000403829.3_Intron	NM_173846.4	NP_776245.2	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family member 2	76						cytoplasm				endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GGCAGTGAAGGAACTGGGCCA	0.502000													29	63					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154625688	154625688	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:154625688C>T	ENST00000260010.6	+	1	3037	c.1629C>T	c.(1627-1629)tcC>tcT	p.S543S		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	543					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				AATTCCTCTCCTTCACTCAGG	0.473000													22	37					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104044065	104044065	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:104044065G>A	ENST00000265148.3	-	43	7195	c.7106C>T	c.(7105-7107)cCt>cTt	p.P2369L	CENPE_ENST00000380026.3_Missense_Mutation_p.P2248L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2369	Kinetochore-binding domain.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TGTAACATGAGGATTCTTATT	0.343000													33	130					0	0	1	0	0
RIT2	6014	broad.mit.edu	37	18	40503539	40503539	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:40503539G>A	ENST00000589109.1	-	4	595	c.424C>T	c.(424-426)Cag>Tag	p.Q142*	RIT2_ENST00000282028.4_Nonsense_Mutation_p.Q142*|RIT2_ENST00000590910.1_Silent_p.A162A|RIT2_ENST00000326695.5_Nonsense_Mutation_p.Q142*	NM_001272077.1	NP_001259006.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	142					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCACTCACCTGGCGGAACTGT	0.458000													42	206					0	0	1	0	0
GPC1	2817	broad.mit.edu	37	2	241405670	241405670	+	Missense_Mutation	SNP	T	T	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:241405670T>A	ENST00000264039.2	+	9	1888	c.1640T>A	c.(1639-1641)tTc>tAc	p.F547Y	GPC1_ENST00000466624.1_3'UTR	NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	547					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		CTCCTCCTCTTCCTGGCCCTT	0.632000													5	59					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052906	44052906	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:44052906C>T	ENST00000306006.6	-	2	1274	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K	ZNF239_ENST00000535642.1_Missense_Mutation_p.E208K|ZNF239_ENST00000374446.2_Missense_Mutation_p.E208K|ZNF239_ENST00000426961.1_Missense_Mutation_p.E208K	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGACTACATTCGTATTGTTTC	0.423000													27	73					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2041160	2041160	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:2041160G>A	ENST00000250896.3	-	12	1233	c.989C>T	c.(988-990)cCc>cTc	p.P330L	MKNK2_ENST00000541165.1_Missense_Mutation_p.P199L|MKNK2_ENST00000309340.7_Missense_Mutation_p.P330L|MKNK2_ENST00000591601.1_Missense_Mutation_p.P330L|MKNK2_ENST00000591142.1_Missense_Mutation_p.P74L|MKNK2_ENST00000588014.1_Missense_Mutation_p.P74L|MKNK2_ENST00000591588.1_Missense_Mutation_p.P74L	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	330	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCTTGTCGGGGAACTCGTA	0.592000													37	84					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27516538	27516538	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr8:27516538G>A	ENST00000301904.3	+	5	871	c.851G>A	c.(850-852)gGg>gAg	p.G284E	SCARA3_ENST00000337221.4_Missense_Mutation_p.G284E	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	284					response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		GCCACCCTGGGGGCCTCCTCA	0.597000													14	32					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14889987	14889987	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chrY:14889987C>T	ENST00000338981.3	+	20	3619	c.2674C>T	c.(2674-2676)Cgg>Tgg	p.R892W	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	892					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TCTTATAGTTCGGTTTCCAAA	0.343000													15	18					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683229	140683229	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140683229G>A	ENST00000239451.4	-	1	383	c.204C>T	c.(202-204)ggC>ggT	p.G68G		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	68					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TAAGTGCCGGGCCGGTGCCCT	0.577000													29	90					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475911	140475911	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:140475911G>A	ENST00000194155.4	+	1	1685	c.1537G>A	c.(1537-1539)Ggc>Agc	p.G513S		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		513	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCGGACAACGGCCACCTGTT	0.701000													58	171					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81743738	81743738	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:81743738C>T	ENST00000555447.1	-	6	2329	c.1917G>A	c.(1915-1917)tgG>tgA	p.W639*	STON2_ENST00000267540.2_Nonsense_Mutation_p.W639*	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	639	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GGAGCTTGATCCACTTTGTGG	0.532000													16	43					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31876800	31876800	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:31876800G>A	ENST00000396184.3	-	12	1401	c.1197C>T	c.(1195-1197)ttC>ttT	p.F399F	PDE1C_ENST00000396182.2_Silent_p.F399F|PDE1C_ENST00000396191.1_Silent_p.F399F|PDE1C_ENST00000321453.7_Silent_p.F399F|PDE1C_ENST00000396193.1_Silent_p.F459F	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	399	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GTACCTGTCTGAAGAACTCCT	0.428000													32	68					0	0	1	0	0
PDE2A	5138	broad.mit.edu	37	11	72307659	72307659	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:72307659C>T	ENST00000334456.5	-	6	712	c.467G>A	c.(466-468)gGg>gAg	p.G156E	PDE2A_ENST00000544570.1_Missense_Mutation_p.G149E|PDE2A_ENST00000418754.2_Intron|PDE2A_ENST00000444035.2_Missense_Mutation_p.G147E|PDE2A_ENST00000540345.1_Missense_Mutation_p.G147E|PDE2A_ENST00000376450.3_Intron	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	156					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	TGCCACGGCCCCAGCCTCCTT	0.647000													9	25					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6985585	6985585	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr18:6985585C>T	ENST00000389658.3	-	38	5530	c.5437G>A	c.(5437-5439)Gga>Aga	p.G1813R		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1813	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATCCTCTTCCTTGGACAATG	0.418000													23	50					0	0	1	0	0
RLN1	6013	broad.mit.edu	37	9	5335409	5335409	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:5335409G>A	ENST00000223862.1	-	2	526	c.400C>T	c.(400-402)Cgc>Tgc	p.R134C	RLN1_ENST00000487557.2_5'UTR|RLN1_ENST00000223858.4_3'UTR	NM_006911.2	NP_008842.1	P04808	REL1_HUMAN	relaxin 1	134					female pregnancy|signal transduction	extracellular region	hormone activity			large_intestine(1)|lung(4)	5	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.02)|Lung(218;0.0984)		TGCCTATTGCGAATAAGTTTC	0.408000													41	88					0	0	1	0	0
TDRKH	11022	broad.mit.edu	37	1	151747249	151747249	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:151747249G>A	ENST00000368822.1	-	12	2203	c.1570C>T	c.(1570-1572)Ctc>Ttc	p.L524F	TDRKH_ENST00000458431.2_Missense_Mutation_p.L524F|TDRKH_ENST00000368823.1_Missense_Mutation_p.L520F|TDRKH_ENST00000440583.2_Missense_Mutation_p.L300F|TDRKH_ENST00000368824.3_Missense_Mutation_p.L524F|TDRKH_ENST00000368825.3_Missense_Mutation_p.L479F|TDRKH_ENST00000368827.6_Missense_Mutation_p.L524F			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	524							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTCTCAGTGAGCAACGTGCTG	0.468000													55	142					0	0	1	0	0
SERPINA9	327657	broad.mit.edu	37	14	94935757	94935757	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:94935757C>T	ENST00000337425.5	-	2	549	c.475G>A	c.(475-477)Gag>Aag	p.E159K	SERPINA9_ENST00000448305.2_Missense_Mutation_p.E61K|SERPINA9_ENST00000424550.2_Missense_Mutation_p.E10K|SERPINA9_ENST00000298845.7_Intron|SERPINA9_ENST00000546329.1_Missense_Mutation_p.E123K|SERPINA9_ENST00000380365.3_Missense_Mutation_p.E141K	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	141					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		AGCTGCAGCTCCTTCTTGACG	0.527000													15	139					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906248	164906248	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:164906248G>A	ENST00000475390.1	-	2	2814	c.2371C>T	c.(2371-2373)Ctc>Ttc	p.L791F	SLITRK3_ENST00000241274.3_Missense_Mutation_p.L791F			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	791						integral to membrane		p.L791I(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CTTCCTAGGAGAGCCTCACCC	0.572000										HNSCC(40;0.11)			39	78					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33467054	33467054	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr5:33467054C>T	ENST00000265112.3	+	18	2298	c.1987C>T	c.(1987-1989)Cga>Tga	p.R663*	TARS_ENST00000541634.1_Nonsense_Mutation_p.R559*|TARS_ENST00000502553.1_Nonsense_Mutation_p.R663*|TARS_ENST00000455217.2_Nonsense_Mutation_p.R696*|TARS_ENST00000414361.2_Nonsense_Mutation_p.R542*	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	663					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity	p.R663*(1)		NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	TAAAAAGATTCGAAATGCACA	0.373000													28	58					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102849529	102849529	+	Silent	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:102849529G>A	ENST00000264257.2	+	10	1368	c.1242G>A	c.(1240-1242)gaG>gaA	p.E414E	IL1RL2_ENST00000539491.1_Silent_p.E414E|IL1RL2_ENST00000441515.2_Silent_p.E296E|IL1RL2_ENST00000481806.1_3'UTR	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	414	TIR.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						AGGTGTTGGAGAGACAATGTG	0.448000													39	73					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124896607	124896607	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:124896607G>A	ENST00000423114.2	-	5	688	c.689C>T	c.(688-690)tCt>tTt	p.S230F	SLC12A8_ENST00000469902.1_Missense_Mutation_p.S201F|SLC12A8_ENST00000314584.7_5'UTR|SLC12A8_ENST00000393469.4_Missense_Mutation_p.S201F			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	201					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						GTGGGTGAAAGAACCCACCAC	0.522000													16	24					0	0	1	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31487875	31487875	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:31487875G>A	ENST00000394863.3	+	9	1092	c.962G>A	c.(961-963)gGa>gAa	p.G321E	TGFB1I1_ENST00000567607.1_Missense_Mutation_p.G304E|TGFB1I1_ENST00000361773.3_Missense_Mutation_p.G304E|TGFB1I1_ENST00000394858.2_Missense_Mutation_p.G304E	NM_001042454.2	NP_001035919.1	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced transcript 1	321	LIM zinc-binding 2.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding			lung(8)|upper_aerodigestive_tract(1)	9						GAGCCCTTCGGAGATGAGGGT	0.637000													5	11					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43869432	43869432	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:43869432C>T	ENST00000562955.1	+	3	314	c.314C>T	c.(313-315)tCt>tTt	p.S105F	SZT2_ENST00000310739.4_Missense_Mutation_p.S105F|SZT2_ENST00000372450.4_Missense_Mutation_p.S103F	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	105						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CTTAGCCCATCTACTGGCATT	0.547000													47	125					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20990669	20990669	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr16:20990669C>T	ENST00000261383.3	-	50	8058	c.8059G>A	c.(8059-8061)Gac>Aac	p.D2687N	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2687	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCTGCAAAGTCGAGTTTCTGC	0.512000													13	44					0	0	1	0	0
CYP27C1	339761	broad.mit.edu	37	2	127944882	127944882	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:127944882C>T	ENST00000335247.7	-	8	1214	c.1084G>A	c.(1084-1086)Ggg>Agg	p.G362R	CYP27C1_ENST00000409327.1_Missense_Mutation_p.G362R	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	362						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		TGGATGGGCCCCCCTGGCGTC	0.473000													33	60					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183652084	183652084	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr4:183652084C>T	ENST00000511685.1	+	16	2882	c.2759C>T	c.(2758-2760)tCc>tTc	p.S920F	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.S920F					teneurin transmembrane protein 3																		TTTGAACGATCCCCATTCCTC	0.418000													21	23					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157414071	157414071	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:157414071G>A	ENST00000389413.3	-	14	2343	c.2240C>T	c.(2239-2241)tCc>tTc	p.S747F	PTPRN2_ENST00000389416.4_Missense_Mutation_p.S759F|PTPRN2_ENST00000404321.2_Missense_Mutation_p.S799F|PTPRN2_ENST00000389418.4_Missense_Mutation_p.S776F|PTPRN2_ENST00000409483.1_Missense_Mutation_p.S738F	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	776	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CACGGCCAGGGAGCGGTTCTT	0.662000													75	207					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21882208	21882208	+	Missense_Mutation	SNP	C	C	T	rs72657399		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:21882208C>T	ENST00000328843.6	+	67	10790	c.10759C>T	c.(10759-10761)Cgc>Tgc	p.R3587C	DNAH11_ENST00000409508.3_Missense_Mutation_p.R3580C			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3587	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CAAGAACTTTCGCCTTATCCT	0.393000									Kartagener syndrome				12	36					0	0	1	0	0
LOC101929735	101929735	broad.mit.edu	37	14	22935530	22935530	+	RNA	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22935530G>A	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA																							TTTCTTCTCAGCCTCTGCCTC	0.458000													12	24					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103814264	103814264	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:103814264C>T	ENST00000302251.5	-	5	1121	c.670G>A	c.(670-672)Gag>Aag	p.E224K	PDGFD_ENST00000393158.2_Missense_Mutation_p.E230K	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	230					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TGCCATGACTCTGGATTGAAG	0.453000													3	28					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154544019	154544019	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:154544019C>T	ENST00000368476.3	+	5	984	c.720C>T	c.(718-720)aaC>aaT	p.N240N		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	240					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	ACACCATCAACCTCATCATCC	0.572000													51	125					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	82147756	82147756	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:82147756G>A	ENST00000550584.2	-	2	540	c.245C>T	c.(244-246)cCa>cTa	p.P82L	PPFIA2_ENST00000333447.7_Missense_Mutation_p.P82L|PPFIA2_ENST00000549325.1_Missense_Mutation_p.P82L|PPFIA2_ENST00000552948.1_Missense_Mutation_p.P82L|PPFIA2_ENST00000548586.1_Missense_Mutation_p.P82L|PPFIA2_ENST00000549396.1_Missense_Mutation_p.P82L	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	340										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GCATACCTGTGGCAGGGCTGA	0.443000													9	19					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108818274	108818274	+	Silent	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:108818274C>T	ENST00000232603.5	-	6	436	c.354G>A	c.(352-354)acG>acA	p.T118T	MORC1_ENST00000483760.1_Silent_p.T118T	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	118					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding	p.T118T(1)		breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						CTTCCTTCTTCGTAAAAAGAA	0.343000													22	38					0	0	1	0	0
SRCRB4D	136853	broad.mit.edu	37	7	76029657	76029657	+	Missense_Mutation	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:76029657C>T	ENST00000275560.3	-	4	768	c.421G>A	c.(421-423)Ggc>Agc	p.G141S	ZP3_ENST00000336517.4_Intron	NM_080744.1	NP_542782.1	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain containing, group B (4 domains)	141	SRCR 1.					extracellular region|membrane	scavenger receptor activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(9)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21						ACGCCCCAGCCGCGGCTGCCG	0.662000													7	43					0	0	1	0	0
TRAV8-6	28680	broad.mit.edu	37	14	22447294	22447294	+	RNA	SNP	C	C	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22447294C>T	ENST00000390443.3	+	0	495																											AGTCAAACTTCCTTCCACTTG	0.483000											OREG0022573	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	81					0	0	1	0	0
FAM180A	389558	broad.mit.edu	37	7	135419000	135419000	+	Missense_Mutation	SNP	G	G	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr7:135419000G>A	ENST00000338588.3	-	3	510	c.245C>T	c.(244-246)tCc>tTc	p.S82F	FAM180A_ENST00000415751.1_Missense_Mutation_p.S82F	NM_205855.3	NP_995327.1	Q6UWF9	F180A_HUMAN	family with sequence similarity 180, member A	82						extracellular region				endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)	14						CTTCCGCAAGGAGGCCAGCTC	0.577000													44	97					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24671417	24671417	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:24671417delA	ENST00000361548.4	+	12	1680	c.1450delA	c.(1450-1452)acfs	p.N484fs	GRHL3_ENST00000342072.4_Frame_Shift_Del_p.N391fs|GRHL3_ENST00000236255.4_Frame_Shift_Del_p.N489fs|GRHL3_ENST00000350501.5_Frame_Shift_Del_p.N484fs|GRHL3_ENST00000356046.2_Frame_Shift_Del_p.N438fs	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	484					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CAGCAGCTCCAACAGGTATGG	0.607													27	54	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152286683	152286684	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr1:152286683_152286684insT	ENST00000368799.1	-	3	713_714	c.678_679insA	c.(676-681)aaggatfs	p.D227fs	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	227					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGTATCCATTTTTGAGTCA	0.347									Ichthyosis				31	108	---	---	---	---					
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													3	6	---	---	---	---					
DNAJB1P1	171221	broad.mit.edu	37	2	192745971	192745985	+	RNA	DEL	CAATAATGAGGTCCC	CAATAATGAGGTCCC	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr2:192745971_192745985delCAATAATGAGGTCCC	ENST00000424116.2	+	0	233																											ACTTCCAATTCAATAATGAGGTCCCCACGTTTCTC	0.516													11	51	---	---	---	---					
OR5H15	403274	broad.mit.edu	37	3	97887844	97887844	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:97887844delT	ENST00000356526.2	+	1	301	c.301delT	c.(301-303)ttfs	p.F102fs		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						CAAGATACAATTTTTTTCCAT	0.383													9	317	---	---	---	---					
RASA2	5922	broad.mit.edu	37	3	141248562	141248562	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr3:141248562delT	ENST00000286364.3	+	4	403	c.368delT	c.(367-369)acfs	p.I123fs	RASA2_ENST00000452898.1_Frame_Shift_Del_p.I123fs			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	123					intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						AAAGTAGCCATCAAAAAAGAA	0.313													45	103	---	---	---	---					
ENTPD2	954	broad.mit.edu	37	9	139946772	139946781	+	Frame_Shift_Del	DEL	GAAGAACCAG	GAAGAACCAG	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr9:139946772_139946781delGAAGAACCAG	ENST00000355097.2	-	2	184_193	c.137_146delCTGGTTCTTC	c.(136-147)gafs	p.AGSS46fs	ENTPD2_ENST00000312665.5_Frame_Shift_Del_p.AGSS46fs	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	46						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGACGTGTGTGAAGAACCAGCGTCCAGGAC	0.605													11	135	---	---	---	---					
GTPBP4	23560	broad.mit.edu	37	10	1063100	1063100	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:1063100delT	ENST00000360803.4	+	17	1920	c.1838delT	c.(1837-1839)ggfs	p.V613fs	GTPBP4_ENST00000538293.1_Frame_Shift_Del_p.V497fs|GTPBP4_ENST00000545048.1_Frame_Shift_Del_p.V566fs	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	613					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		GATAGACACGTGTTTGATATG	0.473													46	107	---	---	---	---					
STOX1	219736	broad.mit.edu	37	10	70645617	70645628	+	In_Frame_Del	DEL	AAAGACTCAGAA	AAAGACTCAGAA	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr10:70645617_70645628delAAAGACTCAGAA	ENST00000298596.6	+	3	2148_2159	c.2065_2076delAAAGACTCAGAA	c.(2065-2076)del	p.KDSE689del	STOX1_ENST00000399162.2_Intron|STOX1_ENST00000399169.4_In_Frame_Del_p.KDSE689del|STOX1_ENST00000421961.2_In_Frame_Del_p.KDSE579del|STOX1_ENST00000399165.4_Intron	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	689						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						AAGACAAGACAAAGACTCAGAAGAATTATTGA	0.406													18	209	---	---	---	---					
TBC1D10C	374403	broad.mit.edu	37	11	67177148	67177149	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr11:67177148_67177149insG	ENST00000312390.5	+	10	1293_1294	c.1264_1265insG	c.(1264-1266)ggcfs	p.G422fs	TBC1D10C_ENST00000542590.1_Frame_Shift_Ins_p.G422fs|TBC1D10C_ENST00000526387.1_3'UTR	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	422	Interaction with calcineurin.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCTCCTGACTCGGGCCCGGGGC	0.698													8	29	---	---	---	---					
SP1	6667	broad.mit.edu	37	12	53776654	53776666	+	Frame_Shift_Del	DEL	CCAGCTTGGTATC	CCAGCTTGGTATC	-	rs139480666	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:53776654_53776666delCCAGCTTGGTATC	ENST00000426431.2	+	3	962_974	c.902_914delCCAGCTTGGTATC	c.(901-915)gafs	p.ASLVS301fs	SP1_ENST00000327443.4_Frame_Shift_Del_p.ASLVS308fs	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	308	Ser/Thr-rich.|Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		ATCAGTTCTGCCAGCTTGGTATCATCACAAGCC	0.512													13	158	---	---	---	---					
CCDC38	120935	broad.mit.edu	37	12	96282260	96282260	+	Frame_Shift_Del	DEL	C	C	-	rs146332701		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:96282260delC	ENST00000344280.3	-	10	1453	c.896delG	c.(895-897)ccfs	p.R299fs	SNRPF_ENST00000552085.1_Intron	NM_182496.2	NP_872302.2	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	299										breast(1)|endometrium(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTCTGGAGTGCGAGTCAGGCT	0.403													96	175	---	---	---	---					
NR1H4	9971	broad.mit.edu	37	12	100904848	100904852	+	Frame_Shift_Del	DEL	TGAGC	TGAGC	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr12:100904848_100904852delTGAGC	ENST00000548884.1	+	4	913_917	c.372_376delTGAGC	c.(370-378)gatgfs	p.DEL124fs	NR1H4_ENST00000392986.3_Frame_Shift_Del_p.DEL124fs|NR1H4_ENST00000188403.7_Frame_Shift_Del_p.DEL134fs|NR1H4_ENST00000549996.1_Frame_Shift_Del_p.DEL124fs|NR1H4_ENST00000551379.1_Frame_Shift_Del_p.DEL134fs	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	134					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.E125*(1)|p.D134E(1)|p.D124E(1)		NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						TCAAAGGGGATGAGCTGTGTGTTGT	0.512													44	126	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20086382	20086383	+	RNA	INS	-	-	AAAA			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:20086382_20086383insAAAA	ENST00000548261.1	+	0	135																											TCTTACAAGGTAAAAAAAATGA	0.312													3	6	---	---	---	---					
TRAV1-1	28693	broad.mit.edu	37	14	22090554	22090555	+	RNA	INS	-	-	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:22090554_22090555insA	ENST00000542354.1	+	0	226_227																											CTGGTACCAGCAACATGATGGC	0.485													68	180	---	---	---	---					
BTBD7	55727	broad.mit.edu	37	14	93761192	93761193	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr14:93761192_93761193insT	ENST00000334746.5	-	3	480_481	c.173_174insA	c.(172-174)aagfs	p.K58fs	BTBD7_ENST00000554565.1_Intron|BTBD7_ENST00000555525.1_Frame_Shift_Ins_p.K58fs|BTBD7_ENST00000298896.3_Frame_Shift_Ins_p.K58fs	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	58								p.K58fs*44(2)|p.R59fs*14(2)		breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		CAGAGGTTCTCTTTTTTTTGTC	0.441													7	319	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25325268	25325268	+	RNA	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25325268delG	ENST00000549804.2	+	0	1377																											TTCCTCATTTGCAGAAACAAA	0.438													32	162	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25467477	25467477	+	RNA	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:25467477delG	ENST00000453082.2	+	0	753					NR_003343.1																						TGCATGGGGAGGGGGGTGCCC	0.537													75	203	---	---	---	---					
RYR3	6263	broad.mit.edu	37	15	33855092	33855092	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:33855092delG	ENST00000389232.4	+	11	1097	c.1027delG	c.(1027-1029)ttfs	p.V343fs	RYR3_ENST00000415757.3_Frame_Shift_Del_p.V343fs	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	343	MIR 5.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGCATGGGAGTTCCAGAAAT	0.433													27	55	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102292874	102292876	+	RNA	DEL	CTC	CTC	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr15:102292874_102292876delCTC	ENST00000561463.1	+	0	920_922																											AGTTCATCTTCTCAGAGCTGCTG	0.581													4	6	---	---	---	---					
CCDC114	93233	broad.mit.edu	37	19	48800553	48800553	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:48800553delG	ENST00000315396.7	-	14	2375	c.1693delC	c.(1693-1695)tcfs	p.L565fs		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	565										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CTGGAGCTGAGGCCGCCAAAA	0.642													15	47	---	---	---	---					
KLK12	43849	broad.mit.edu	37	19	51535204	51535204	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr19:51535204delG	ENST00000525263.1	-	3	504	c.385delC	c.(385-387)tgfs	p.L129fs	KLK12_ENST00000250352.11_Intron|KLK12_ENST00000319590.4_Frame_Shift_Del_p.L129fs|KLK12_ENST00000529888.1_Intron|CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000250351.4_Frame_Shift_Del_p.L129fs			Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	129	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		TCATTGGGCAGGGGCAGGGGT	0.697													13	87	---	---	---	---					
DSCAM	1826	broad.mit.edu	37	21	41427714	41427714	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	3954c345-d993-4edd-a917-fcef21e3a3b8	g.chr21:41427714delA	ENST00000400454.1	-	29	5450	c.4973delT	c.(4972-4974)agfs	p.M1658fs		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1658					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTCGATGTGCATTCGCAGGGT	0.453													77	165	---	---	---	---					
GRHL3	57822	broad.mit.edu	37	1	24671417	24671417	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:24671417delA	ENST00000361548.4	+	12	1680	c.1450delA	c.(1450-1452)acfs	p.N484fs	GRHL3_ENST00000350501.5_Frame_Shift_Del_p.N484fs|GRHL3_ENST00000342072.4_Frame_Shift_Del_p.N391fs|GRHL3_ENST00000356046.2_Frame_Shift_Del_p.N438fs|GRHL3_ENST00000236255.4_Frame_Shift_Del_p.N489fs	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	484					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CAGCAGCTCCAACAGGTATGG	0.607													27	54	---	---	---	---					
FLG	2312	broad.mit.edu	37	1	152286683	152286684	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr1:152286683_152286684insT	ENST00000368799.1	-	3	713_714	c.678_679insA	c.(676-681)aaggatfs	p.D227fs	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	227					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGTATCCATTTTTGAGTCA	0.347									Ichthyosis				31	108	---	---	---	---					
DNAJB1P1	171221	broad.mit.edu	37	2	192745971	192745985	+	RNA	DEL	CAATAATGAGGTCCC	CAATAATGAGGTCCC	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr2:192745971_192745985delCAATAATGAGGTCCC	ENST00000424116.2	+	0	233																											ACTTCCAATTCAATAATGAGGTCCCCACGTTTCTC	0.516													11	51	---	---	---	---					
RASA2	5922	broad.mit.edu	37	3	141248562	141248562	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr3:141248562delT	ENST00000286364.3	+	4	403	c.368delT	c.(367-369)acfs	p.I123fs	RASA2_ENST00000452898.1_Frame_Shift_Del_p.I123fs			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	123					intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						AAAGTAGCCATCAAAAAAGAA	0.313													45	103	---	---	---	---					
FOXD4	2298	broad.mit.edu	37	9	117406	117407	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:117406_117407insG	ENST00000382500.2	-	1	1010_1011	c.713_714insC	c.(712-714)cccfs	p.P238fs		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	238	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGGCTGCGGCGGGGCAGGGGC	0.743													8	87	---	---	---	---					
KGFLP2	654466	broad.mit.edu	37	9	41962602	41962602	+	RNA	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:41962602delG	ENST00000454645.1	-	0	902					NR_003670.1																						TTCTTTCTTTGTTTTTTTTCC	0.373													8	101	---	---	---	---					
ENTPD2	954	broad.mit.edu	37	9	139946772	139946781	+	Frame_Shift_Del	DEL	GAAGAACCAG	GAAGAACCAG	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr9:139946772_139946781delGAAGAACCAG	ENST00000355097.2	-	2	184_193	c.137_146delCTGGTTCTTC	c.(136-147)gafs	p.AGSS46fs	ENTPD2_ENST00000312665.5_Frame_Shift_Del_p.AGSS46fs	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	46						integral to membrane	ATP binding			endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGACGTGTGTGAAGAACCAGCGTCCAGGAC	0.605													11	135	---	---	---	---					
GTPBP4	23560	broad.mit.edu	37	10	1063100	1063100	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:1063100delT	ENST00000360803.4	+	17	1920	c.1838delT	c.(1837-1839)ggfs	p.V613fs	GTPBP4_ENST00000545048.1_Frame_Shift_Del_p.V566fs|GTPBP4_ENST00000538293.1_Frame_Shift_Del_p.V497fs	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	613					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		GATAGACACGTGTTTGATATG	0.473													46	107	---	---	---	---					
STOX1	219736	broad.mit.edu	37	10	70645617	70645628	+	In_Frame_Del	DEL	AAAGACTCAGAA	AAAGACTCAGAA	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr10:70645617_70645628delAAAGACTCAGAA	ENST00000298596.6	+	3	2148_2159	c.2065_2076delAAAGACTCAGAA	c.(2065-2076)del	p.KDSE689del	STOX1_ENST00000421961.2_In_Frame_Del_p.KDSE579del|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000399169.4_In_Frame_Del_p.KDSE689del|STOX1_ENST00000399162.2_Intron	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	689						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						AAGACAAGACAAAGACTCAGAAGAATTATTGA	0.406													18	209	---	---	---	---					
TBC1D10C	374403	broad.mit.edu	37	11	67177148	67177149	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr11:67177148_67177149insG	ENST00000312390.5	+	10	1293_1294	c.1264_1265insG	c.(1264-1266)ggcfs	p.G422fs	TBC1D10C_ENST00000542590.1_Frame_Shift_Ins_p.G422fs|TBC1D10C_ENST00000526387.1_3'UTR	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	422	Interaction with calcineurin.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCTCCTGACTCGGGCCCGGGGC	0.698													8	29	---	---	---	---					
SP1	6667	broad.mit.edu	37	12	53776654	53776666	+	Frame_Shift_Del	DEL	CCAGCTTGGTATC	CCAGCTTGGTATC	-	rs139480666	byFrequency	TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:53776654_53776666delCCAGCTTGGTATC	ENST00000426431.2	+	3	962_974	c.902_914delCCAGCTTGGTATC	c.(901-915)gafs	p.ASLVS301fs	SP1_ENST00000327443.4_Frame_Shift_Del_p.ASLVS308fs	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	308	Ser/Thr-rich.|Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		ATCAGTTCTGCCAGCTTGGTATCATCACAAGCC	0.512													13	158	---	---	---	---					
CCDC38	120935	broad.mit.edu	37	12	96282260	96282260	+	Frame_Shift_Del	DEL	C	C	-	rs146332701		TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:96282260delC	ENST00000344280.3	-	10	1453	c.896delG	c.(895-897)ccfs	p.R299fs	SNRPF_ENST00000552085.1_Intron	NM_182496.2	NP_872302.2	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	299										breast(1)|endometrium(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTCTGGAGTGCGAGTCAGGCT	0.403													96	175	---	---	---	---					
NR1H4	9971	broad.mit.edu	37	12	100904848	100904852	+	Frame_Shift_Del	DEL	TGAGC	TGAGC	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:100904848_100904852delTGAGC	ENST00000548884.1	+	4	913_917	c.372_376delTGAGC	c.(370-378)gatgfs	p.DEL124fs	NR1H4_ENST00000551379.1_Frame_Shift_Del_p.DEL134fs|NR1H4_ENST00000549996.1_Frame_Shift_Del_p.DEL124fs|NR1H4_ENST00000392986.3_Frame_Shift_Del_p.DEL124fs|NR1H4_ENST00000188403.7_Frame_Shift_Del_p.DEL134fs	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	134					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.E125*(1)|p.D134E(1)|p.D124E(1)		NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						TCAAAGGGGATGAGCTGTGTGTTGT	0.512													44	126	---	---	---	---					
CLIP1	6249	broad.mit.edu	37	12	122812690	122812691	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr12:122812690_122812691insT	ENST00000358808.2	-	16	3173_3174	c.3019_3020insA	c.(3019-3021)ccafs	p.P1007fs	CLIP1_ENST00000302528.7_Frame_Shift_Ins_p.P1007fs|CLIP1_ENST00000537178.1_Frame_Shift_Ins_p.P972fs|CLIP1_ENST00000545889.1_Frame_Shift_Ins_p.P593fs|CLIP1_ENST00000540338.1_Frame_Shift_Ins_p.P1018fs|CLIP1_ENST00000361654.4_Frame_Shift_Ins_p.P896fs	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	1018					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTGGTTGTGGCTTGTTTCCATT	0.505													11	220	---	---	---	---					
TRAV1-1	28693	broad.mit.edu	37	14	22090554	22090555	+	RNA	INS	-	-	A			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:22090554_22090555insA	ENST00000542354.1	+	0	226_227																											CTGGTACCAGCAACATGATGGC	0.485													68	180	---	---	---	---					
BTBD7	55727	broad.mit.edu	37	14	93761192	93761193	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr14:93761192_93761193insT	ENST00000334746.5	-	3	480_481	c.173_174insA	c.(172-174)aagfs	p.K58fs	BTBD7_ENST00000554565.1_Intron|BTBD7_ENST00000298896.3_Frame_Shift_Ins_p.K58fs|BTBD7_ENST00000555525.1_Frame_Shift_Ins_p.K58fs	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	58								p.K58fs*44(2)|p.R59fs*14(2)		breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		CAGAGGTTCTCTTTTTTTTGTC	0.441													7	319	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25325268	25325268	+	RNA	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25325268delG	ENST00000549804.2	+	0	1377																											TTCCTCATTTGCAGAAACAAA	0.438													32	162	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25467477	25467477	+	RNA	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:25467477delG	ENST00000453082.2	+	0	753					NR_003343.1																						TGCATGGGGAGGGGGGTGCCC	0.537													75	203	---	---	---	---					
RYR3	6263	broad.mit.edu	37	15	33855092	33855092	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr15:33855092delG	ENST00000389232.4	+	11	1097	c.1027delG	c.(1027-1029)ttfs	p.V343fs	RYR3_ENST00000415757.3_Frame_Shift_Del_p.V343fs	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	343	MIR 5.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGCATGGGAGTTCCAGAAAT	0.433													27	55	---	---	---	---					
CCDC114	93233	broad.mit.edu	37	19	48800553	48800553	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:48800553delG	ENST00000315396.7	-	14	2375	c.1693delC	c.(1693-1695)tcfs	p.L565fs		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	565										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CTGGAGCTGAGGCCGCCAAAA	0.642													15	47	---	---	---	---					
KLK12	43849	broad.mit.edu	37	19	51535204	51535204	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr19:51535204delG	ENST00000525263.1	-	3	504	c.385delC	c.(385-387)tgfs	p.L129fs	CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000250351.4_Frame_Shift_Del_p.L129fs|KLK12_ENST00000319590.4_Frame_Shift_Del_p.L129fs|KLK12_ENST00000529888.1_Intron|KLK12_ENST00000250352.11_Intron			Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	129	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		TCATTGGGCAGGGGCAGGGGT	0.697													13	87	---	---	---	---					
DSCAM	1826	broad.mit.edu	37	21	41427714	41427714	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FW-A3R5-06A-11D-A23B-08	TCGA-FW-A3R5-11A-11D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbe8943-60cd-4c58-b502-91f50f33f7d6	4e26c9db-ec8a-4d88-9f74-a45db7287a39	g.chr21:41427714delA	ENST00000400454.1	-	29	5450	c.4973delT	c.(4972-4974)agfs	p.M1658fs		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1658					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTCGATGTGCATTCGCAGGGT	0.453													77	165	---	---	---	---					
